Cancer_type QTL_type tag_SNP LD SNP SNP_position Alleles Methylation_probe Methylation_position Probe_related_gene Beta t-stat Correlation_coefficient (r) p-value Traits CRC cis rs4700695 0.841 rs251325 chr5:65269618 A/G cg21114390 chr5:65439923 SFRS12 0.59 7.24 0.37 3.26e-12 Facial morphology (factor 19); CRC cis rs9393777 0.513 rs13210025 chr6:26654817 A/C cg12292205 chr6:26970375 C6orf41 -0.61 -6.97 -0.36 1.76e-11 Intelligence (multi-trait analysis); CRC trans rs1814175 0.529 rs10839396 chr11:49852406 G/T cg15704280 chr7:45808275 SEPT13 0.81 11.35 0.53 2.08e-25 Height; CRC cis rs6748734 0.600 rs10933510 chr2:241826754 G/A cg16358738 chr2:241808595 AGXT -0.41 -7.06 -0.36 9.73e-12 Urinary metabolites; CRC cis rs734999 0.588 rs78506337 chr1:2537095 G/A cg20673091 chr1:2541236 MMEL1 0.36 5.76 0.3 1.92e-8 Ulcerative colitis; CRC cis rs919433 0.927 rs1429418 chr2:198158151 G/C cg20885578 chr2:198174922 NA -0.43 -6.83 -0.35 4.03e-11 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC cis rs826838 0.585 rs12296822 chr12:38625829 A/T cg13010199 chr12:38710504 ALG10B -0.42 -6.03 -0.32 4.33e-9 Heart rate; CRC cis rs1448094 0.785 rs7955173 chr12:86447214 G/A cg18827107 chr12:86230957 RASSF9 0.37 5.81 0.3 1.5e-8 Major depressive disorder; CRC cis rs73206853 0.841 rs55741511 chr12:110880613 G/T cg12870014 chr12:110450643 ANKRD13A 0.75 6.53 0.34 2.44e-10 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC cis rs77633900 0.772 rs387321 chr15:76743565 A/G cg21673338 chr15:77095150 SCAPER -0.69 -6.07 -0.32 3.6e-9 Non-glioblastoma glioma;Glioma; CRC cis rs10504229 0.562 rs2014516 chr8:58128288 C/A cg05313129 chr8:58192883 C8orf71 -0.43 -6.11 -0.32 2.74e-9 Developmental language disorder (linguistic errors); CRC cis rs548181 0.604 rs11608103 chr11:125627917 G/A cg03464685 chr11:125439445 EI24 -0.83 -9.31 -0.46 1.86e-18 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs6681460 0.898 rs536527 chr1:67193793 A/C cg02459107 chr1:67143332 SGIP1 0.37 6.47 0.34 3.62e-10 Presence of antiphospholipid antibodies; CRC cis rs9487051 0.676 rs9400267 chr6:109600164 T/C cg21918786 chr6:109611834 NA -0.4 -7.13 -0.37 6.28e-12 Reticulocyte fraction of red cells; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg11021810 chr14:89720620 FOXN3 -0.38 -6.41 -0.33 5.07e-10 Liver disease severity in Alagille syndrome; CRC trans rs916888 0.773 rs199443 chr17:44819565 C/T cg10053473 chr17:62856997 LRRC37A3 -0.78 -8.85 -0.44 5.46e-17 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs514406 0.893 rs499195 chr1:53344907 C/T cg24675658 chr1:53192096 ZYG11B -0.53 -7.72 -0.39 1.44e-13 Monocyte count; CRC cis rs9487051 0.807 rs7748641 chr6:109592381 C/T cg12927641 chr6:109611667 NA -0.37 -6.71 -0.35 8.55e-11 Reticulocyte fraction of red cells; CRC cis rs752010 0.756 rs6600380 chr1:42054814 C/T cg06885757 chr1:42089581 HIVEP3 -0.32 -5.74 -0.3 2.19e-8 Lupus nephritis in systemic lupus erythematosus; CRC cis rs1348850 0.634 rs2293471 chr2:178487729 T/G cg22681709 chr2:178499509 PDE11A -0.37 -6.07 -0.32 3.62e-9 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC trans rs877282 0.853 rs10904545 chr10:757100 G/A cg22713356 chr15:30763199 NA 1.2 14.06 0.61 1.69e-35 Uric acid levels; CRC cis rs7274811 0.711 rs291689 chr20:32003974 A/G cg03904042 chr20:32255491 NECAB3;C20orf134 0.38 5.81 0.3 1.51e-8 Height; CRC cis rs4555082 0.874 rs760270 chr14:105737785 A/G cg18132624 chr14:105716052 BTBD6;BRF1 -0.47 -7.51 -0.38 5.64e-13 Mean platelet volume;Platelet distribution width; CRC cis rs57590327 0.528 rs11707026 chr3:81694044 C/A cg07356753 chr3:81810745 GBE1 -0.61 -7.98 -0.4 2.42e-14 Extraversion; CRC trans rs1814175 0.645 rs7123448 chr11:49764865 T/G cg03929089 chr4:120376271 NA -0.92 -15.68 -0.65 8.93e-42 Height; CRC cis rs4731207 0.698 rs886704 chr7:124422266 C/T cg23710748 chr7:124431027 NA -0.37 -5.85 -0.31 1.16e-8 Cutaneous malignant melanoma; CRC cis rs9486715 0.790 rs2971602 chr6:97022468 C/T cg06623918 chr6:96969491 KIAA0776 -1.03 -20.89 -0.76 2.86e-62 Headache; CRC cis rs4689388 0.926 rs10010131 chr4:6292915 A/G cg25554036 chr4:6271136 WFS1 0.54 8.76 0.44 1.02e-16 Type 2 diabetes and other traits;Type 2 diabetes; CRC trans rs7726839 0.540 rs72707016 chr5:665148 A/G cg11887960 chr12:57824829 NA 0.66 7.1 0.36 7.76e-12 Obesity-related traits; CRC cis rs10540 1.000 rs35068485 chr11:466032 A/T cg03352830 chr11:487213 PTDSS2 0.67 7.86 0.4 5.71e-14 Body mass index; CRC cis rs4965359 0.643 rs2924846 chr15:101598522 A/G cg01350081 chr15:101592003 LRRK1 -0.35 -5.96 -0.31 6.48e-9 Central corneal thickness; CRC cis rs11628318 0.508 rs3950014 chr14:103069889 G/A cg23071808 chr14:103021642 NA -0.64 -7.19 -0.37 4.38e-12 Platelet count; CRC cis rs17209837 0.607 rs10452936 chr7:87094306 C/A cg00919237 chr7:87102261 ABCB4 -0.54 -7.09 -0.36 8.37e-12 Gallbladder cancer; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg20140173 chr1:155036019 EFNA4 0.44 6.17 0.32 2.05e-9 Response to antipsychotic treatment; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg16369786 chr1:63153804 DOCK7 0.46 6.43 0.33 4.4e-10 Response to antipsychotic treatment; CRC cis rs916888 0.773 rs199457 chr17:44795469 C/T cg15921436 chr17:44337874 NA 0.79 8.44 0.42 1.05e-15 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs9467711 0.591 rs72834617 chr6:25999175 G/A cg08501292 chr6:25962987 TRIM38 0.84 7.76 0.39 1.1e-13 Autism spectrum disorder or schizophrenia; CRC cis rs2811415 0.597 rs1042907 chr3:127789172 G/C cg13719885 chr3:127795394 NA -0.4 -6.05 -0.32 3.83e-9 Lung function (FEV1/FVC); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg01637218 chr1:29063669 YTHDF2 0.42 5.99 0.31 5.59e-9 Intelligence (multi-trait analysis); CRC cis rs79976124 0.837 rs74327235 chr6:66648353 T/A cg07460842 chr6:66804631 NA 0.75 9.38 0.46 1.07e-18 Type 2 diabetes; CRC cis rs2239547 0.522 rs6445550 chr3:52983434 G/A cg10802521 chr3:52805072 NEK4 -0.46 -6.33 -0.33 8.09e-10 Schizophrenia; CRC cis rs4523957 0.928 rs8066372 chr17:2180968 A/G cg16513277 chr17:2031491 SMG6 -0.54 -9.12 -0.45 7.45e-18 Autism spectrum disorder or schizophrenia;Schizophrenia; CRC cis rs9649213 0.613 rs7777415 chr7:97959214 A/T cg00277769 chr7:97922759 BAIAP2L1 -0.6 -10.45 -0.5 2.99e-22 Prostate cancer (SNP x SNP interaction); CRC trans rs7671189 0.522 rs13113451 chr4:11744920 A/G cg18054620 chr5:111191530 C5orf13 -0.3 -5.99 -0.31 5.43e-9 Obesity-related traits; CRC trans rs10983614 1.000 rs7867776 chr9:120072627 A/G cg07491357 chr18:9914943 VAPA 0.46 6.04 0.32 4.22e-9 Survival in pancreatic cancer; CRC cis rs1153858 1.000 rs4534782 chr15:45652933 G/A cg14582100 chr15:45693742 SPATA5L1 0.3 6.2 0.32 1.71e-9 Homoarginine levels; CRC cis rs6942756 1.000 rs2103232 chr7:128951232 G/T cg02491457 chr7:128862824 NA -0.76 -10.46 -0.5 2.65e-22 White matter hyperintensity burden; CRC cis rs2976388 1.000 rs10216533 chr8:143763690 G/A cg24046110 chr8:143859143 LYNX1 -0.37 -6.38 -0.33 6.16e-10 Urinary tract infection frequency; CRC cis rs2239547 0.563 rs6797399 chr3:52905917 G/A cg11645453 chr3:52864694 ITIH4 0.55 9.47 0.46 5.8e-19 Schizophrenia; CRC cis rs2346160 0.867 rs206975 chr6:167690356 A/G cg27333441 chr6:167680455 NA -0.38 -6.43 -0.33 4.4e-10 Parental extreme longevity (95 years and older); CRC cis rs7927592 0.913 rs12363722 chr11:68236291 A/C cg16797656 chr11:68205561 LRP5 0.38 6.07 0.32 3.52e-9 Total body bone mineral density; CRC cis rs11148252 0.595 rs9526974 chr13:53251040 C/G cg00495681 chr13:53174319 NA 0.85 15.68 0.65 9.21e-42 Lewy body disease; CRC cis rs11711311 1.000 rs12632983 chr3:113481913 A/C cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.51 -6.94 -0.36 2.06e-11 IgG glycosylation; CRC cis rs10464366 0.544 rs12701697 chr7:39182165 C/T cg20302533 chr7:39170763 POU6F2 0.41 5.66 0.3 3.38e-8 IgG glycosylation; CRC cis rs67478160 0.608 rs4906368 chr14:104242397 A/C cg01849466 chr14:104193079 ZFYVE21 -0.55 -10.37 -0.5 5.62e-22 Schizophrenia; CRC cis rs6860806 0.531 rs2631359 chr5:131707892 C/T cg11843238 chr5:131593191 PDLIM4 -0.44 -7.45 -0.38 8.45e-13 Breast cancer; CRC cis rs35306767 0.953 rs10904581 chr10:964685 A/T cg26597838 chr10:835615 NA 0.82 10.28 0.49 1.08e-21 Eosinophil percentage of granulocytes; CRC cis rs6088580 0.634 rs6142153 chr20:32968747 C/G cg24642439 chr20:33292090 TP53INP2 -0.38 -6.42 -0.33 4.73e-10 Glomerular filtration rate (creatinine); CRC cis rs875971 0.755 rs76288834 chr7:66069802 G/A cg18876405 chr7:65276391 NA -0.53 -8.53 -0.43 5.37e-16 Aortic root size; CRC cis rs514406 0.627 rs485128 chr1:53344583 T/C cg24675658 chr1:53192096 ZYG11B -0.65 -9.62 -0.47 1.86e-19 Monocyte count; CRC cis rs853679 0.760 rs2299029 chr6:28198831 G/A cg25164649 chr6:28176230 NA 0.57 6.12 0.32 2.72e-9 Depression; CRC cis rs910316 0.737 rs175045 chr14:75475275 A/C cg08847533 chr14:75593920 NEK9 -0.89 -14.05 -0.61 1.85e-35 Height; CRC cis rs9911578 1.000 rs12453049 chr17:56611372 C/T cg12560992 chr17:57184187 TRIM37 -0.91 -17.13 -0.69 1.81e-47 Intelligence (multi-trait analysis); CRC trans rs7395662 0.548 rs4882000 chr11:48546496 A/G cg15704280 chr7:45808275 SEPT13 -0.48 -6.86 -0.35 3.35e-11 HDL cholesterol; CRC trans rs944990 0.595 rs10123378 chr9:96375217 C/T cg24829313 chr11:63684597 RCOR2 0.35 5.99 0.31 5.39e-9 Body mass index; CRC cis rs6835098 0.923 rs9997477 chr4:174112543 C/T cg08422745 chr4:174089978 GALNT7 -0.94 -14.98 -0.64 4.65e-39 Dementia and core Alzheimer's disease neuropathologic changes; CRC cis rs995000 0.868 rs1007205 chr1:62936912 T/C cg19896129 chr1:63156450 NA -0.44 -6.75 -0.35 6.68e-11 Triglyceride levels; CRC cis rs3996993 0.724 rs2749029 chr6:52631188 A/G cg20803780 chr6:52668592 GSTA1 -0.33 -5.9 -0.31 8.79e-9 Hemoglobin concentration; CRC cis rs896854 0.596 rs7823059 chr8:95974961 T/C cg16049864 chr8:95962084 TP53INP1 -0.65 -11.81 -0.55 4.64e-27 Type 2 diabetes; CRC cis rs3806843 0.735 rs2530242 chr5:140053351 G/C cg19875535 chr5:140030758 IK -0.64 -10.4 -0.5 4.17e-22 Depressive symptoms (multi-trait analysis); CRC cis rs2380220 0.872 rs4546494 chr6:95990626 A/C cg07718321 chr6:96025334 MANEA 0.49 5.81 0.3 1.51e-8 Behavioural disinhibition (generation interaction); CRC cis rs67311347 0.506 rs55962832 chr3:40244451 T/C cg09455208 chr3:40491958 NA 0.34 6.98 0.36 1.63e-11 Renal cell carcinoma; CRC cis rs2197308 0.728 rs7304305 chr12:37932990 T/C cg13010199 chr12:38710504 ALG10B -0.49 -7.2 -0.37 4.19e-12 Morning vs. evening chronotype; CRC cis rs17092148 0.887 rs6059919 chr20:33151545 G/T cg08999081 chr20:33150536 PIGU 0.52 6.34 0.33 7.61e-10 Neuroticism; CRC cis rs10493773 0.609 rs6689168 chr1:86174232 G/T cg00734567 chr1:86172782 ZNHIT6 -0.48 -7.3 -0.37 2.21e-12 Urate levels in overweight individuals; CRC cis rs6502050 0.835 rs11077971 chr17:80090629 A/G cg13198984 chr17:80129470 CCDC57 0.45 7.89 0.4 4.6e-14 Life satisfaction; CRC cis rs1577917 1.000 rs12663651 chr6:86701655 T/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.52 -6.8 -0.35 5.06e-11 Response to antipsychotic treatment; CRC cis rs35110281 0.744 rs230644 chr21:44917183 C/T cg04455712 chr21:45112962 RRP1B -0.38 -7.09 -0.36 8.02e-12 Mean corpuscular volume; CRC cis rs28386778 0.765 rs2070680 chr17:61986988 A/G cg11494091 chr17:61959527 GH2 -0.7 -13.48 -0.6 2.8e-33 Prudent dietary pattern; CRC cis rs12142240 0.698 rs17361819 chr1:46828109 A/G cg00530320 chr1:46809349 NSUN4 0.59 8.11 0.41 1.02e-14 Menopause (age at onset); CRC cis rs2857891 1.000 rs1388527 chr11:6948441 C/T cg17958423 chr11:6947583 ZNF215 0.53 5.63 0.3 3.81e-8 Response to cytadine analogues (cytosine arabinoside); CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg23375783 chr17:73008576 ICT1 0.39 6.3 0.33 9.7e-10 Obesity-related traits; CRC trans rs10506458 0.834 rs58821476 chr12:63389425 T/C cg22491629 chr6:157744540 C6orf35 -0.73 -8.33 -0.42 2.18e-15 Hemostatic factors and hematological phenotypes; CRC cis rs3091242 0.900 rs1811832 chr1:25753565 G/A cg02931644 chr1:25747376 RHCE 0.32 5.64 0.3 3.72e-8 Erythrocyte sedimentation rate; CRC cis rs11792861 0.591 rs7027874 chr9:111717112 A/G cg14432460 chr9:111696404 IKBKAP;C9orf6 0.51 7.29 0.37 2.32e-12 Menarche (age at onset); CRC cis rs7712401 0.791 rs6887101 chr5:122109207 C/T cg18764291 chr5:122110994 SNX2 -0.41 -6.44 -0.33 4.16e-10 Mean platelet volume; CRC cis rs7945705 0.747 rs1980429 chr11:9010474 C/A cg00186954 chr11:8933980 ST5;C11orf17 -0.46 -7.71 -0.39 1.47e-13 Hemoglobin concentration; CRC trans rs7726839 0.507 rs111707179 chr5:593308 T/A cg11887960 chr12:57824829 NA 0.59 6.73 0.35 7.55e-11 Obesity-related traits; CRC cis rs853679 0.517 rs12174753 chr6:28042465 C/G cg25164649 chr6:28176230 NA 0.72 9.0 0.44 1.82e-17 Depression; CRC trans rs9914544 0.524 rs7209853 chr17:18798600 G/A cg21372672 chr17:16614065 CCDC144A -0.39 -6.12 -0.32 2.7e-9 Educational attainment (years of education); CRC cis rs9911578 1.000 rs8071280 chr17:57010225 T/C cg12560992 chr17:57184187 TRIM37 0.92 17.22 0.69 8.15e-48 Intelligence (multi-trait analysis); CRC cis rs2836974 0.897 rs2836924 chr21:40525639 C/T cg17971929 chr21:40555470 PSMG1 0.84 12.96 0.58 2.62e-31 Cognitive function; CRC cis rs9905704 0.647 rs11652713 chr17:57079742 C/T cg12560992 chr17:57184187 TRIM37 0.63 9.66 0.47 1.3e-19 Testicular germ cell tumor; CRC cis rs9311474 0.597 rs13303 chr3:52558008 T/C cg18591801 chr3:52553433 STAB1 -0.31 -5.91 -0.31 8.35e-9 Electroencephalogram traits; CRC cis rs6860806 0.507 rs272892 chr5:131664349 C/T cg24060327 chr5:131705240 SLC22A5 -0.51 -7.65 -0.39 2.23e-13 Breast cancer; CRC cis rs17711722 0.653 rs2460421 chr7:65491123 A/T cg18876405 chr7:65276391 NA -0.62 -10.82 -0.51 1.5e-23 Calcium levels; CRC cis rs909674 0.818 rs8137426 chr22:39844350 T/G cg05872129 chr22:39784769 NA -0.48 -8.24 -0.41 4.17e-15 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; CRC cis rs8014204 0.836 rs8021280 chr14:75290018 C/G cg03030879 chr14:75389066 RPS6KL1 -0.5 -8.07 -0.41 1.3e-14 Caffeine consumption; CRC cis rs7527798 0.592 rs10863461 chr1:207840776 C/T cg09232269 chr1:207846808 CR1L -0.51 -8.33 -0.42 2.2e-15 Erythrocyte sedimentation rate; CRC cis rs7772486 0.817 rs2144477 chr6:146406248 C/T cg13319975 chr6:146136371 FBXO30 -0.39 -6.01 -0.31 4.94e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs2625529 0.526 rs8032222 chr15:72479178 C/G cg16672083 chr15:72433130 SENP8 0.43 6.38 0.33 6.11e-10 Red blood cell count; CRC cis rs10865541 0.806 rs4971503 chr2:3417221 G/A cg22182287 chr2:3452347 TTC15 0.38 5.96 0.31 6.57e-9 Obesity-related traits; CRC cis rs1799949 1.000 rs12942277 chr17:41187974 G/C cg19454999 chr17:41278357 BRCA1;NBR2 0.52 7.75 0.39 1.14e-13 Menopause (age at onset); CRC cis rs11098499 0.708 rs11732686 chr4:120252330 C/A cg24375607 chr4:120327624 NA 0.47 7.6 0.39 3.06e-13 Corneal astigmatism; CRC cis rs8077889 0.672 rs2074143 chr17:41856622 A/G cg26893861 chr17:41843967 DUSP3 1.08 20.35 0.75 3.48e-60 Triglycerides; CRC trans rs7615952 0.733 rs13314847 chr3:125644788 C/T cg21747405 chr11:67723411 NA -0.44 -6.26 -0.33 1.23e-9 Blood pressure (smoking interaction); CRC cis rs7113874 0.524 rs9734055 chr11:8577236 C/A cg02811074 chr11:8615871 STK33 -0.34 -5.87 -0.31 1.05e-8 Body mass index in physically active individuals;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs2290405 0.527 rs4690332 chr4:910520 C/T cg04045327 chr4:905805 GAK 0.44 7.67 0.39 1.94e-13 Systemic sclerosis; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg00846248 chr7:86849067 C7orf23 0.38 6.0 0.31 5.09e-9 Liver disease severity in Alagille syndrome; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg05307864 chr6:160559487 SLC22A1 0.39 6.04 0.32 4.15e-9 Liver disease severity in Alagille syndrome; CRC cis rs2739330 0.760 rs1007888 chr22:24241101 C/T cg24846343 chr22:24311635 DDTL 0.75 12.66 0.57 3.36e-30 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs2153535 0.580 rs3938660 chr6:8443335 G/A cg21535247 chr6:8435926 SLC35B3 0.48 7.24 0.37 3.19e-12 Motion sickness; CRC cis rs1538970 1.000 rs61791368 chr1:45867944 T/C cg05343316 chr1:45956843 TESK2 0.7 9.47 0.46 5.57e-19 Platelet count; CRC cis rs4903604 0.581 rs41347855 chr14:78037909 C/T cg18872420 chr14:78023429 SPTLC2 0.35 6.06 0.32 3.63e-9 Gut microbiome composition (winter); CRC cis rs9457247 0.967 rs2757054 chr6:167380501 A/G cg23791538 chr6:167370224 RNASET2 0.39 6.08 0.32 3.37e-9 Crohn's disease; CRC cis rs1018836 0.608 rs1033348 chr8:91464169 C/G cg16814680 chr8:91681699 NA -0.51 -8.0 -0.4 2.11e-14 Ejection fraction in Tripanosoma cruzi seropositivity; CRC cis rs1008375 0.966 rs12509962 chr4:17680292 G/A cg16339924 chr4:17578868 LAP3 0.51 6.66 0.34 1.19e-10 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs6502050 0.835 rs4789737 chr17:80123269 G/A cg19223190 chr17:80058835 NA 0.39 6.23 0.32 1.43e-9 Life satisfaction; CRC cis rs2153535 0.580 rs1577471 chr6:8485905 T/A cg21535247 chr6:8435926 SLC35B3 0.5 7.51 0.38 5.54e-13 Motion sickness; CRC cis rs3741151 0.773 rs7934218 chr11:73206729 C/T cg17517138 chr11:73019481 ARHGEF17 0.55 5.84 0.31 1.25e-8 GIP levels in response to oral glucose tolerance test (120 minutes); CRC cis rs11628318 0.660 rs35258120 chr14:103058769 G/A cg08075719 chr14:103021372 NA -0.61 -7.48 -0.38 6.67e-13 Platelet count; CRC cis rs7762018 1.000 rs41265383 chr6:170068025 T/C cg19338460 chr6:170058176 WDR27 -0.76 -8.3 -0.42 2.78e-15 Thiazide-induced adverse metabolic effects in hypertensive patients; CRC cis rs4664293 0.625 rs6722715 chr2:160525026 T/C cg08347373 chr2:160653686 CD302 0.39 6.52 0.34 2.67e-10 Monocyte percentage of white cells; CRC trans rs1814175 0.935 rs7479914 chr11:49661351 T/C cg03929089 chr4:120376271 NA -0.94 -17.28 -0.69 4.54e-48 Height; CRC cis rs7527798 0.592 rs960086 chr1:207827069 A/G cg09232269 chr1:207846808 CR1L -0.45 -7.31 -0.37 2.02e-12 Erythrocyte sedimentation rate; CRC cis rs597539 0.652 rs604524 chr11:68629929 G/A cg06028808 chr11:68637592 NA 0.42 6.91 0.36 2.49e-11 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs1008375 1.000 rs28497813 chr4:17685503 A/G cg04450456 chr4:17643702 FAM184B 0.39 6.31 0.33 8.97e-10 Parasitemia in Tripanosoma cruzi seropositivity; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg15803122 chr17:75277207 SEPT9 0.44 6.29 0.33 9.84e-10 Anxiety disorder; CRC cis rs7959452 0.590 rs7968629 chr12:69782857 G/A cg14784868 chr12:69753453 YEATS4 0.83 14.18 0.62 6.16e-36 Blood protein levels; CRC cis rs7666738 0.791 rs4699324 chr4:98967496 G/A cg05340658 chr4:99064831 C4orf37 0.6 9.43 0.46 7.76e-19 Colonoscopy-negative controls vs population controls; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg11725182 chr1:5968678 NPHP4 -0.38 -6.32 -0.33 8.27e-10 Liver disease severity in Alagille syndrome; CRC cis rs868943 0.743 rs1890425 chr6:116339295 T/C cg05304507 chr6:116381966 FRK 0.29 6.52 0.34 2.61e-10 Total cholesterol levels; CRC cis rs868943 0.743 rs4628134 chr6:116360141 A/G cg26893134 chr6:116381904 FRK 0.25 6.14 0.32 2.33e-9 Total cholesterol levels; CRC cis rs6500395 0.832 rs8052733 chr16:48691978 C/T cg04672837 chr16:48644449 N4BP1 -0.45 -6.63 -0.34 1.38e-10 Response to tocilizumab in rheumatoid arthritis; CRC trans rs11148252 0.538 rs2296349 chr13:52710058 T/G cg18335740 chr13:41363409 SLC25A15 0.53 7.94 0.4 3.22e-14 Lewy body disease; CRC cis rs9915657 0.870 rs759499 chr17:70133177 C/T cg09344028 chr17:70110421 NA 0.43 6.63 0.34 1.41e-10 Thyroid hormone levels; CRC cis rs875971 0.895 rs4718349 chr7:65909011 C/G cg18876405 chr7:65276391 NA 0.52 8.85 0.44 5.32e-17 Aortic root size; CRC cis rs10782582 0.609 rs111914775 chr1:76319036 C/T cg10523679 chr1:76189770 ACADM -0.41 -5.71 -0.3 2.49e-8 Daytime sleep phenotypes; CRC cis rs7618915 0.547 rs8906 chr3:52739520 T/C cg11645453 chr3:52864694 ITIH4 0.38 6.62 0.34 1.47e-10 Bipolar disorder; CRC cis rs10504229 0.679 rs4737454 chr8:58033965 A/T cg22535103 chr8:58192502 C8orf71 -0.44 -6.15 -0.32 2.23e-9 Developmental language disorder (linguistic errors); CRC cis rs79057730 0.528 rs6965219 chr7:821807 C/G cg11064039 chr7:766100 PRKAR1B;HEATR2 0.57 5.99 0.31 5.47e-9 Initial pursuit acceleration; CRC cis rs61774743 0.557 rs4359027 chr1:41848296 G/A cg08462924 chr1:41848221 NA 0.45 7.03 0.36 1.2e-11 Intelligence (multi-trait analysis); CRC cis rs9818758 0.607 rs9850917 chr3:49286983 A/G cg00383909 chr3:49044727 WDR6 1.14 11.5 0.54 5.77e-26 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; CRC cis rs6951245 0.638 rs74976697 chr7:1160505 C/T cg03188948 chr7:1209495 NA 0.63 7.0 0.36 1.47e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs7772486 0.790 rs7753833 chr6:146161432 C/A cg23711669 chr6:146136114 FBXO30 0.68 11.48 0.53 6.86e-26 Lobe attachment (rater-scored or self-reported); CRC trans rs7615952 1.000 rs7616044 chr3:125649354 G/C cg02560186 chr11:3602584 NA -0.44 -6.06 -0.32 3.72e-9 Blood pressure (smoking interaction); CRC cis rs12580194 0.593 rs57050414 chr12:55776926 G/A cg19537932 chr12:55886519 OR6C68 -0.75 -9.21 -0.45 3.8e-18 Cancer; CRC trans rs6951245 0.935 rs78573577 chr7:1089087 C/A cg13565492 chr6:43139072 SRF -0.71 -7.12 -0.37 7.03e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs7666738 0.830 rs35531558 chr4:98938217 A/G cg05340658 chr4:99064831 C4orf37 0.6 9.35 0.46 1.41e-18 Colonoscopy-negative controls vs population controls; CRC cis rs10865541 0.967 rs6755448 chr2:3397359 T/C cg22182287 chr2:3452347 TTC15 0.38 5.92 0.31 7.9e-9 Obesity-related traits; CRC cis rs35883536 0.609 rs12747197 chr1:101036831 A/C cg06223162 chr1:101003688 GPR88 -0.36 -6.61 -0.34 1.58e-10 Monocyte count; CRC cis rs4665809 0.759 rs62128394 chr2:26364026 T/G cg26119090 chr2:26468346 HADHA;HADHB 0.73 7.61 0.39 2.93e-13 Gut microbiome composition (summer); CRC cis rs6570726 0.791 rs6914203 chr6:145899975 C/A cg05347473 chr6:146136440 FBXO30 0.37 5.64 0.3 3.62e-8 Lobe attachment (rater-scored or self-reported); CRC cis rs7762018 0.891 rs12529402 chr6:170147675 A/T cg17545662 chr6:170176663 C6orf70 0.57 6.45 0.34 3.99e-10 Thiazide-induced adverse metabolic effects in hypertensive patients; CRC cis rs9858542 0.537 rs9818758 chr3:49382925 G/A cg00383909 chr3:49044727 WDR6 0.72 7.36 0.38 1.52e-12 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs738321 0.794 rs5756940 chr22:38558842 C/T cg25457927 chr22:38595422 NA -0.34 -6.59 -0.34 1.78e-10 Breast cancer; CRC cis rs6714710 0.580 rs6711101 chr2:98379813 G/A cg26665480 chr2:98280029 ACTR1B 0.49 6.83 0.35 4.05e-11 Posterior cortical atrophy and Alzheimer's disease; CRC cis rs951366 0.764 rs708724 chr1:205743663 A/C cg17178900 chr1:205818956 PM20D1 0.68 10.18 0.49 2.4e-21 Menarche (age at onset); CRC cis rs1816752 0.905 rs6490928 chr13:25014059 T/C cg02811702 chr13:24901961 NA 0.47 6.55 0.34 2.16e-10 Obesity-related traits; CRC trans rs208520 0.955 rs28684412 chr6:66979430 A/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.88 10.79 0.51 1.94e-23 Exhaled nitric oxide output; CRC cis rs427941 0.632 rs201478 chr7:101746964 G/C cg06246474 chr7:101738831 CUX1 0.43 6.62 0.34 1.45e-10 Plasma omega-3 polyunsaturated fatty acid level (eicosapentaenoic acid); CRC cis rs9443645 0.527 rs2063123 chr6:79658535 T/C cg09184832 chr6:79620586 NA -0.46 -8.02 -0.4 1.93e-14 Intelligence (multi-trait analysis); CRC cis rs8067545 1.000 rs7218708 chr17:19926836 A/G cg13482628 chr17:19912719 NA 0.52 8.08 0.41 1.24e-14 Schizophrenia; CRC cis rs4237845 0.636 rs11172371 chr12:58286188 C/T cg00677455 chr12:58241039 CTDSP2 0.83 10.98 0.52 4.16e-24 Intelligence (multi-trait analysis); CRC cis rs524281 0.861 rs918299 chr11:65927607 C/T cg16950941 chr11:66035639 RAB1B -0.58 -7.24 -0.37 3.27e-12 Electroencephalogram traits; CRC cis rs10504229 1.000 rs66495524 chr8:58187365 C/T cg01721255 chr8:58191610 C8orf71 0.49 6.17 0.32 2e-9 Developmental language disorder (linguistic errors); CRC cis rs11098499 0.754 rs11732087 chr4:120239831 A/G cg24375607 chr4:120327624 NA 0.48 7.64 0.39 2.32e-13 Corneal astigmatism; CRC cis rs1005277 0.522 rs7072977 chr10:37940440 C/A cg00409905 chr10:38381863 ZNF37A -0.63 -9.96 -0.48 1.31e-20 Extrinsic epigenetic age acceleration; CRC cis rs4665809 0.590 rs6716858 chr2:26423414 G/A cg26119090 chr2:26468346 HADHA;HADHB -0.9 -13.43 -0.6 4.19e-33 Gut microbiome composition (summer); CRC trans rs2303319 0.504 rs12467662 chr2:162386784 G/A cg09481857 chr22:21368659 P2RX6;MGC16703 -0.64 -6.1 -0.32 3.04e-9 Cognitive function; CRC cis rs4713118 0.662 rs175954 chr6:28011585 A/G cg25164649 chr6:28176230 NA 0.67 9.19 0.45 4.68e-18 Parkinson's disease; CRC cis rs2197308 0.765 rs117216293 chr12:37882982 T/C cg26384229 chr12:38710491 ALG10B -0.61 -9.28 -0.46 2.37e-18 Morning vs. evening chronotype; CRC cis rs6570726 0.791 rs441290 chr6:145883183 A/G cg23711669 chr6:146136114 FBXO30 0.68 11.36 0.53 1.95e-25 Lobe attachment (rater-scored or self-reported); CRC cis rs2072499 0.838 rs2758619 chr1:156162559 A/G cg25208724 chr1:156163844 SLC25A44 1.1 26.81 0.83 9.1200000000000006e-85 Testicular germ cell tumor; CRC cis rs709400 1.000 rs57218990 chr14:104128007 T/A cg01849466 chr14:104193079 ZFYVE21 0.35 5.72 0.3 2.37e-8 Body mass index; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg06805572 chr2:10444432 HPCAL1 0.47 6.55 0.34 2.24e-10 Response to antipsychotic treatment; CRC cis rs55665837 1.000 rs10832269 chr11:14465069 C/A cg19336497 chr11:14380999 RRAS2 -0.38 -6.54 -0.34 2.29e-10 Vitamin D levels; CRC cis rs7639513 0.767 rs9878151 chr3:12703714 G/C cg23032965 chr3:12705835 RAF1 0.66 10.21 0.49 1.98e-21 Itch intensity from mosquito bite; CRC cis rs12931792 0.720 rs12102320 chr16:30178516 A/C cg17640201 chr16:30407289 ZNF48 0.44 6.44 0.33 4.16e-10 Tonsillectomy; CRC cis rs4363385 0.510 rs6689066 chr1:153045154 T/C cg25856811 chr1:152973957 SPRR3 -0.21 -5.66 -0.3 3.22e-8 Inflammatory skin disease; CRC cis rs2075371 0.933 rs1421480 chr7:133958114 A/C cg11752832 chr7:134001865 SLC35B4 0.44 6.72 0.35 8.13e-11 Mean platelet volume; CRC trans rs4263408 0.934 rs9683743 chr4:39703194 A/C cg21769114 chr3:32726526 CNOT10 -0.45 -6.6 -0.34 1.64e-10 Plasma amyloid beta peptide concentrations (ABx-40); CRC cis rs2327429 0.541 rs12193973 chr6:134151297 A/G cg06296503 chr6:134217401 NA -0.37 -5.81 -0.31 1.47e-8 Coronary artery disease; CRC cis rs6951245 0.935 rs11766669 chr7:1063593 C/T cg07217954 chr7:1067459 C7orf50 0.56 5.75 0.3 2e-8 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC trans rs2727020 0.688 rs4929894 chr11:49196333 G/C cg11707556 chr5:10655725 ANKRD33B -0.35 -6.33 -0.33 7.93e-10 Coronary artery disease; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg01258499 chr20:30540016 PDRG1 0.41 6.02 0.31 4.7e-9 Intelligence (multi-trait analysis); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg05951993 chr19:49496864 GYS1;RUVBL2 0.46 6.62 0.34 1.45e-10 Response to antipsychotic treatment; CRC cis rs7617773 0.817 rs4131362 chr3:48329036 A/C cg11946769 chr3:48343235 NME6 0.64 8.87 0.44 4.91e-17 Coronary artery disease; CRC cis rs796364 0.951 rs281769 chr2:200809709 T/C cg12253985 chr2:200820533 C2orf60;C2orf47 0.59 6.55 0.34 2.19e-10 Schizophrenia; CRC cis rs7647973 0.961 rs7619016 chr3:49272589 C/T cg20833759 chr3:49053208 WDR6;DALRD3 0.53 7.84 0.4 6.23e-14 Menarche (age at onset); CRC cis rs11677416 1.000 rs2856841 chr2:113537339 A/G cg27083787 chr2:113543245 IL1A 0.52 7.01 0.36 1.4e-11 Response to antipsychotic treatment in schizophrenia (working memory); CRC cis rs4713118 0.869 rs9348775 chr6:27695329 C/T cg02683197 chr6:28174875 NA 0.6 8.08 0.41 1.25e-14 Parkinson's disease; CRC cis rs7312774 1.000 rs7312774 chr12:107305728 G/A cg16260113 chr12:107380972 MTERFD3 0.74 7.49 0.38 6.43e-13 Severe influenza A (H1N1) infection; CRC cis rs4722166 0.630 rs13311155 chr7:22789789 A/C cg26061582 chr7:22766209 IL6 0.53 8.03 0.4 1.77e-14 Lung cancer; CRC cis rs4280164 0.945 rs2281472 chr14:24775846 C/T cg16194253 chr14:24768981 DHRS1;C14orf21 0.58 6.95 0.36 1.97e-11 Parent of origin effect on language impairment (paternal); CRC cis rs1451375 0.572 rs11575463 chr7:50547173 A/G cg14593290 chr7:50529359 DDC -0.63 -8.3 -0.42 2.64e-15 Malaria; CRC cis rs947211 0.846 rs708726 chr1:205762139 G/T cg14159672 chr1:205819179 PM20D1 -0.44 -6.33 -0.33 8.19e-10 Parkinson's disease; CRC cis rs6912958 0.559 rs1201409 chr6:88055264 T/C cg12350822 chr6:88032061 C6orf162;GJB7 0.46 9.52 0.46 3.83e-19 Monocyte percentage of white cells; CRC cis rs3026445 0.926 rs28609096 chr12:110815922 A/G cg12870014 chr12:110450643 ANKRD13A 0.37 5.76 0.3 1.96e-8 QT interval; CRC cis rs637571 0.780 rs677029 chr11:65683531 A/G cg04055107 chr11:65626734 MUS81;CFL1 0.47 6.5 0.34 2.97e-10 Eosinophil percentage of white cells; CRC cis rs8072100 0.713 rs11651643 chr17:45483229 A/G cg08085267 chr17:45401833 C17orf57 -0.57 -8.68 -0.43 1.81e-16 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs9291683 0.588 rs34501273 chr4:9996996 C/T cg00071950 chr4:10020882 SLC2A9 0.59 11.19 0.52 7.86e-25 Bone mineral density; CRC trans rs951252 0.504 rs11734405 chr4:146081096 C/T cg08584628 chr5:178286875 ZNF354B 0.48 6.27 0.33 1.16e-9 Hip circumference; CRC cis rs9649213 0.574 rs62479853 chr7:97917158 G/T cg00277769 chr7:97922759 BAIAP2L1 -0.61 -10.81 -0.51 1.7e-23 Prostate cancer (SNP x SNP interaction); CRC cis rs6860806 0.507 rs272883 chr5:131668698 A/G cg12564285 chr5:131593104 PDLIM4 0.44 7.44 0.38 8.72e-13 Breast cancer; CRC cis rs904251 0.523 rs1776455 chr6:37482923 A/T cg25019722 chr6:37503610 NA -0.47 -8.76 -0.43 1.05e-16 Cognitive performance; CRC cis rs7412746 0.658 rs6656535 chr1:150940357 G/T cg10589385 chr1:150898437 SETDB1 0.33 6.98 0.36 1.68e-11 Melanoma; CRC cis rs9914988 0.576 rs67777803 chr17:27323322 G/T cg16670446 chr17:27188758 MIR451;MIR144 0.47 6.45 0.34 3.97e-10 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs6951245 1.000 rs11763020 chr7:1060288 C/T cg22907277 chr7:1156413 C7orf50 0.7 7.38 0.38 1.31e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC trans rs11098499 0.605 rs6833140 chr4:120266822 G/A cg25214090 chr10:38739885 LOC399744 0.53 8.51 0.42 6.36e-16 Corneal astigmatism; CRC cis rs1008375 0.966 rs4698619 chr4:17580955 G/A cg16339924 chr4:17578868 LAP3 0.6 8.0 0.4 2.16e-14 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs58688157 0.705 rs12419694 chr11:598033 C/T cg01842473 chr11:617407 IRF7;MUPCDH -0.55 -6.69 -0.35 9.54e-11 Systemic lupus erythematosus; CRC cis rs12042938 0.507 rs2570408 chr1:231732934 C/T cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.58 -8.97 -0.44 2.34e-17 Neuranatomic and neurocognitive phenotypes; CRC cis rs9469578 1.000 rs60447213 chr6:33715159 G/T cg18708504 chr6:33715942 IP6K3 0.66 7.56 0.38 4e-13 Phosphorus levels; CRC cis rs12497850 0.931 rs11924597 chr3:48937790 T/C cg20833759 chr3:49053208 WDR6;DALRD3 0.53 9.22 0.45 3.67e-18 Parkinson's disease; CRC trans rs1607741 1.000 rs10005014 chr4:72712010 C/T cg06437464 chr6:127441704 RSPO3 -0.29 -6.13 -0.32 2.48e-9 Vitamin D levels; CRC cis rs6788895 1.000 rs6803830 chr3:150510579 A/G cg09723797 chr3:150481914 SIAH2 0.89 5.93 0.31 7.58e-9 Breast cancer; CRC cis rs4629710 0.592 rs66533103 chr6:131531016 C/T cg12606694 chr6:131520996 AKAP7 0.6 8.79 0.44 8.19e-17 Multiple myeloma (IgH translocation); CRC cis rs10193935 0.901 rs2286701 chr2:42555636 T/C cg27598129 chr2:42591480 NA -0.71 -8.17 -0.41 6.71e-15 Colonoscopy-negative controls vs population controls; CRC cis rs7786877 0.723 rs62482239 chr7:100217810 C/T cg16850897 chr7:100343110 ZAN -0.51 -6.31 -0.33 8.78e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs9488822 0.702 rs12196154 chr6:116327471 T/G cg26893134 chr6:116381904 FRK 0.26 7.61 0.39 2.98e-13 Cholesterol, total;LDL cholesterol; CRC cis rs9814567 1.000 rs4974483 chr3:134219001 A/G cg06109529 chr3:134205091 CEP63;ANAPC13 -0.8 -11.94 -0.55 1.47e-27 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs4713118 0.824 rs9468223 chr6:27740666 C/T cg21251018 chr6:28226885 NKAPL 0.43 6.18 0.32 1.86e-9 Parkinson's disease; CRC cis rs3820068 0.603 rs6660234 chr1:15962590 T/C cg13390004 chr1:15929781 NA 0.5 7.06 0.36 1.02e-11 Systolic blood pressure; CRC cis rs910316 0.935 rs175448 chr14:75591071 G/A cg03030879 chr14:75389066 RPS6KL1 0.46 7.2 0.37 4.2e-12 Height; CRC cis rs2976388 0.632 rs2585139 chr8:143808175 C/G cg12516270 chr8:143859308 LYNX1 0.43 7.46 0.38 7.89e-13 Urinary tract infection frequency; CRC cis rs1552244 0.882 rs56224841 chr3:10044014 A/C cg18598329 chr3:10140678 FANCD2;C3orf24 -0.81 -10.69 -0.51 4.35e-23 Alzheimer's disease; CRC cis rs1129187 0.902 rs10948059 chr6:42928461 C/T cg02359409 chr6:42947317 PEX6 -0.58 -9.23 -0.45 3.46e-18 Alzheimer's disease in APOE e4+ carriers; CRC cis rs10504229 0.683 rs72650849 chr8:58140323 A/G cg05313129 chr8:58192883 C8orf71 -0.43 -6.11 -0.32 2.74e-9 Developmental language disorder (linguistic errors); CRC cis rs9916302 0.904 rs4794814 chr17:37696852 G/A cg03013999 chr17:37608204 MED1 0.47 7.21 0.37 3.76e-12 Glomerular filtration rate (creatinine); CRC cis rs11719291 0.831 rs11715177 chr3:48763894 G/A cg07636037 chr3:49044803 WDR6 -0.71 -6.59 -0.34 1.72e-10 Cognitive function; CRC cis rs9463078 0.505 rs2038556 chr6:44740568 A/G cg25276700 chr6:44698697 NA 0.3 7.76 0.39 1.09e-13 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; CRC trans rs6600671 1.000 rs4844616 chr1:121171208 A/G cg09829573 chr1:144692074 NBPF9 -0.4 -6.05 -0.32 3.87e-9 Hip geometry; CRC cis rs12188164 0.686 rs72711367 chr5:418494 A/G cg00976097 chr5:421733 AHRR -0.45 -6.08 -0.32 3.28e-9 Cystic fibrosis severity; CRC cis rs4654899 0.861 rs10916876 chr1:21169996 T/C cg02927042 chr1:21476669 EIF4G3 0.42 6.7 0.35 8.96e-11 Superior frontal gyrus grey matter volume; CRC cis rs858239 0.932 rs858272 chr7:23276785 A/G cg00469287 chr7:23338798 C7orf30 0.43 5.82 0.31 1.42e-8 Cerebrospinal fluid biomarker levels; CRC cis rs13191362 1.000 rs13209100 chr6:163159350 C/T cg06582575 chr6:163149167 PACRG;PARK2 0.76 11.09 0.52 1.78e-24 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs6700896 0.966 rs3790439 chr1:66085574 T/A cg04111102 chr1:66153794 NA 0.33 5.95 0.31 6.81e-9 C-reactive protein;Mean corpuscular volume;Mean corpuscular hemoglobin; CRC cis rs826838 1.000 rs7953227 chr12:38946193 G/A cg26384229 chr12:38710491 ALG10B 0.72 10.16 0.49 2.93e-21 Heart rate; CRC cis rs3093024 0.967 rs1571878 chr6:167540842 C/T cg07741184 chr6:167504864 NA -0.4 -7.12 -0.37 6.65e-12 Rheumatoid arthritis; CRC cis rs1801251 0.711 rs778339 chr2:233739678 T/C cg25237894 chr2:233734115 C2orf82 -0.64 -11.32 -0.53 2.6e-25 Coronary artery disease; CRC cis rs10242455 0.702 rs6977165 chr7:99269397 T/C cg18809830 chr7:99032528 PTCD1 -1.04 -7.41 -0.38 1.05e-12 Blood metabolite levels; CRC cis rs7927592 0.956 rs11228256 chr11:68251460 G/A cg16797656 chr11:68205561 LRP5 0.39 6.23 0.32 1.46e-9 Total body bone mineral density; CRC cis rs7408868 0.908 rs10418660 chr19:15278635 A/G cg14696996 chr19:15285081 NOTCH3 0.96 8.96 0.44 2.53e-17 Pulse pressure; CRC cis rs3857067 1.000 rs1904094 chr4:95012459 A/G cg11021082 chr4:95130006 SMARCAD1 -0.4 -6.05 -0.32 3.9e-9 QT interval; CRC cis rs832540 1.000 rs192249 chr5:56197514 C/G cg24531977 chr5:56204891 C5orf35 -0.46 -7.09 -0.36 8.36e-12 Coronary artery disease; CRC cis rs1696756 0.638 rs1290396 chr17:77830767 C/T cg00646381 chr17:77835854 NA 0.42 6.63 0.34 1.39e-10 Glucocorticoid-induced osteonecrosis (age 10 years and older); CRC cis rs9910055 0.502 rs1684662 chr17:42180822 T/A cg10896456 chr17:42255109 ASB16;C17orf65 -0.37 -5.81 -0.31 1.47e-8 Total body bone mineral density; CRC cis rs7927592 0.956 rs55816191 chr11:68262979 G/T cg01657329 chr11:68192670 LRP5 -0.48 -7.26 -0.37 2.88e-12 Total body bone mineral density; CRC trans rs3807766 0.581 rs6954104 chr7:77693258 C/T cg05370988 chr3:186500739 EIF4A2 -0.45 -6.13 -0.32 2.53e-9 3-hydroxypropylmercapturic acid levels in smokers; CRC cis rs13201294 1 rs13201294 chr6:27556141 A/T cg26958806 chr6:27640298 NA 0.84 6.41 0.33 5.07e-10 Squamous cell lung carcinoma; CRC trans rs6951245 1.000 rs80094748 chr7:1103958 G/A cg13565492 chr6:43139072 SRF -0.72 -7.42 -0.38 1.01e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs7772486 0.712 rs6570726 chr6:146159460 T/C cg05347473 chr6:146136440 FBXO30 0.37 5.81 0.31 1.48e-8 Lobe attachment (rater-scored or self-reported); CRC trans rs17807624 0.780 rs11250152 chr8:11454200 A/C cg06636001 chr8:8085503 FLJ10661 -0.45 -6.1 -0.32 2.91e-9 Systemic lupus erythematosus; CRC cis rs1448094 0.512 rs6539931 chr12:86247473 C/T cg00310523 chr12:86230176 RASSF9 0.35 5.93 0.31 7.63e-9 Major depressive disorder; CRC cis rs3806843 0.801 rs2531358 chr5:140117437 A/G cg19875535 chr5:140030758 IK -0.62 -10.19 -0.49 2.18e-21 Depressive symptoms (multi-trait analysis); CRC cis rs2730260 0.578 rs56375711 chr7:158854935 G/A cg02254261 chr7:158964346 NA -0.53 -6.0 -0.31 5.3300000000000004e-09 Myopia (pathological); CRC cis rs7959452 0.590 rs56054057 chr12:69775972 C/T cg22834771 chr12:69754056 YEATS4 -0.54 -8.11 -0.41 1e-14 Blood protein levels; CRC cis rs79349575 0.783 rs62075839 chr17:46996434 G/C cg22482690 chr17:47019901 SNF8 0.48 8.07 0.41 1.33e-14 Type 2 diabetes; CRC cis rs1941023 0.568 rs1373064 chr11:60168200 C/T cg08716584 chr11:60157161 MS4A7 -0.55 -8.99 -0.44 2.04e-17 Congenital heart disease (maternal effect); CRC cis rs12024301 0.557 rs10797901 chr1:183663303 C/G cg11505048 chr1:183622726 RGL1;APOBEC4 0.71 6.24 0.33 1.33e-9 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs56104184 0.775 rs73063505 chr19:49402765 T/C cg21252483 chr19:49399788 TULP2 -0.43 -6.52 -0.34 2.59e-10 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; CRC cis rs780096 0.506 rs8395 chr2:27715207 T/A cg12648201 chr2:27665141 KRTCAP3 -0.3 -5.9 -0.31 8.93e-9 Total body bone mineral density; CRC cis rs1030268 0.640 rs12707092 chr7:133188145 C/G cg10665199 chr7:133106180 EXOC4 0.62 7.7 0.39 1.58e-13 Intelligence (multi-trait analysis); CRC cis rs79839061 0.610 rs3775122 chr4:893287 A/G cg07828340 chr4:882639 GAK -1.18 -11.7 -0.54 1.1e-26 Intelligence (multi-trait analysis); CRC cis rs875971 0.830 rs427973 chr7:65526648 C/A cg00343986 chr7:65444356 GUSB 0.45 6.65 0.34 1.25e-10 Aortic root size; CRC trans rs7690467 0.794 rs1875024 chr4:133395895 C/T cg05523500 chr3:73046033 PPP4R2 -0.45 -6.16 -0.32 2.13e-9 Eating disorders; CRC cis rs7843479 0.582 rs13439690 chr8:21778082 T/C cg17168535 chr8:21777572 XPO7 0.69 11.78 0.54 5.97e-27 Mean corpuscular volume; CRC cis rs4638749 0.677 rs2378098 chr2:108849381 T/C cg25838818 chr2:108905173 SULT1C2 -0.34 -5.85 -0.31 1.16e-8 Blood pressure; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg00052422 chr3:41240987 CTNNB1 0.44 6.67 0.35 1.05e-10 Intelligence (multi-trait analysis); CRC cis rs6761276 0.932 rs10186133 chr2:113836944 G/T cg09040174 chr2:113837401 NA 0.65 9.8 0.48 4.48e-20 Protein quantitative trait loci; CRC cis rs875971 0.838 rs2173570 chr7:65762963 T/A cg12463550 chr7:65579703 CRCP -0.5 -7.08 -0.36 8.57e-12 Aortic root size; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg23350889 chr12:133100618 FBRSL1 0.45 6.15 0.32 2.19e-9 Anxiety disorder; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg04784101 chr11:66824465 RHOD 0.38 6.19 0.32 1.75e-9 Liver disease severity in Alagille syndrome; CRC cis rs9287719 0.578 rs10175555 chr2:10703233 T/C cg00105475 chr2:10696890 NA 0.48 7.25 0.37 2.99e-12 Prostate cancer; CRC trans rs61931739 0.500 rs3924705 chr12:34557825 A/T cg26384229 chr12:38710491 ALG10B 0.6 8.84 0.44 5.75e-17 Morning vs. evening chronotype; CRC cis rs4237845 0.537 rs11172369 chr12:58280592 T/C cg02175503 chr12:58329896 NA 0.5 5.99 0.31 5.6e-9 Intelligence (multi-trait analysis); CRC cis rs2230307 0.536 rs11166384 chr1:100439890 C/T cg24955406 chr1:100503596 HIAT1 0.59 7.13 0.37 6.35e-12 Carotid intima media thickness; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg08269949 chr6:26538502 HMGN4 0.53 7.06 0.36 9.99e-12 Thyroid stimulating hormone; CRC cis rs6582630 0.519 rs7294300 chr12:38277359 C/A cg26384229 chr12:38710491 ALG10B 0.69 9.22 0.45 3.69e-18 Drug-induced liver injury (flucloxacillin); CRC cis rs3862030 0.720 rs1056744 chr10:104236687 A/G cg11453585 chr10:104263688 ACTR1A;SUFU -0.8 -14.41 -0.62 8.04e-37 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for body mass index; CRC cis rs7666738 0.822 rs979946 chr4:98921235 C/A cg17366294 chr4:99064904 C4orf37 0.43 7.28 0.37 2.45e-12 Colonoscopy-negative controls vs population controls; CRC cis rs5769707 0.521 rs7285764 chr22:50058561 T/C cg20744362 chr22:50050164 C22orf34 0.32 5.82 0.31 1.38e-8 Monocyte count;Monocyte percentage of white cells; CRC cis rs7615952 0.576 rs6780025 chr3:125815624 A/C cg06494592 chr3:125709126 NA -0.58 -6.89 -0.35 2.9100000000000002e-11 Blood pressure (smoking interaction); CRC cis rs597539 0.690 rs497149 chr11:68626639 A/T cg04772025 chr11:68637568 NA 0.54 8.53 0.43 5.26e-16 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs2882667 0.690 rs700629 chr5:138123994 T/G cg09476006 chr5:138032270 NA -0.59 -10.75 -0.51 2.69e-23 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs1862618 0.853 rs252909 chr5:56121131 T/C cg20203395 chr5:56204925 C5orf35 -0.69 -8.24 -0.41 4.19e-15 Initial pursuit acceleration; CRC trans rs12478296 0.792 rs57482298 chr2:243011148 C/A cg18288967 chr1:45987694 PRDX1 0.62 6.87 0.35 3.27e-11 Obesity-related traits; CRC cis rs57994353 0.897 rs55824202 chr9:139357273 A/T cg14119001 chr9:139324193 INPP5E -0.44 -6.18 -0.32 1.91e-9 Eosinophil counts;Cutaneous squamous cell carcinoma; CRC trans rs9650657 0.711 rs35091929 chr8:10693492 T/C cg06636001 chr8:8085503 FLJ10661 -0.46 -6.62 -0.34 1.48e-10 Neuroticism; CRC cis rs7618915 1.000 rs34569561 chr3:52287293 T/C cg18404041 chr3:52824283 ITIH1 -0.36 -6.59 -0.34 1.73e-10 Bipolar disorder; CRC cis rs11105306 1 rs11105306 chr12:89897388 C/T cg00757033 chr12:89920650 WDR51B 0.38 6.57 0.34 1.99e-10 NT-proBNP levels in acute coronary syndrome; CRC cis rs11098499 0.954 rs10031665 chr4:120422852 T/C cg09307838 chr4:120376055 NA 0.71 10.96 0.52 5.0600000000000004e-24 Corneal astigmatism; CRC cis rs17767392 1.000 rs34524083 chr14:71858372 C/T cg13720639 chr14:72061746 SIPA1L1 -0.55 -6.95 -0.36 1.96e-11 Mitral valve prolapse; CRC cis rs1005277 0.579 rs2008449 chr10:38414204 A/T cg17219203 chr10:38645113 HSD17B7P2 0.41 5.98 0.31 5.92e-9 Extrinsic epigenetic age acceleration; CRC cis rs7605827 0.930 rs4410258 chr2:15594984 A/C cg19274914 chr2:15703543 NA 0.39 5.9 0.31 9.14e-9 Educational attainment (years of education); CRC cis rs1577917 0.958 rs11758508 chr6:86506878 A/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A 0.47 5.87 0.31 1.05e-8 Response to antipsychotic treatment; CRC cis rs909002 0.849 rs3753611 chr1:32082486 C/T cg13919466 chr1:32135498 COL16A1 -0.32 -5.98 -0.31 5.87e-9 Intelligence (multi-trait analysis); CRC cis rs8005677 1.000 rs2295685 chr14:23398153 A/G cg25600027 chr14:23388339 RBM23 -0.51 -7.88 -0.4 4.8e-14 Cognitive ability (multi-trait analysis); CRC cis rs2404602 0.647 rs11072616 chr15:76985269 T/C cg23625390 chr15:77176239 SCAPER -0.88 -15.07 -0.64 2.12e-39 Blood metabolite levels; CRC trans rs800082 0.698 rs800074 chr3:144347638 A/G cg24215973 chr2:240111563 HDAC4 -0.74 -10.24 -0.49 1.52e-21 Smoking behavior; CRC cis rs968567 0.906 rs61897793 chr11:61599347 G/A cg06781209 chr11:61594997 FADS2 -0.77 -8.84 -0.44 6.1e-17 Blood metabolite levels;Rheumatoid arthritis;Vitiligo;Glycerophospholipid levels; CRC cis rs11722228 1.000 rs6825187 chr4:9915325 T/C cg00071950 chr4:10020882 SLC2A9 -0.47 -7.1 -0.36 7.96e-12 Gout;Urate levels;Serum uric acid levels; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg10513480 chr14:21852135 SUPT16H 0.41 6.33 0.33 8.13e-10 Liver disease severity in Alagille syndrome; CRC cis rs703842 1.000 rs10783848 chr12:58196528 G/A cg00677455 chr12:58241039 CTDSP2 0.67 9.42 0.46 8.41e-19 Multiple sclerosis; CRC trans rs1005277 0.579 rs2749616 chr10:38510993 A/T cg11292332 chr7:45801988 SEPT13 -0.38 -6.81 -0.35 4.75e-11 Extrinsic epigenetic age acceleration; CRC cis rs9916302 0.904 rs2168785 chr17:37407135 C/T cg00129232 chr17:37814104 STARD3 -0.52 -7.76 -0.39 1.1e-13 Glomerular filtration rate (creatinine); CRC cis rs4853012 0.887 rs77148265 chr2:74339519 C/T cg20891558 chr2:74357851 NA 0.66 10.34 0.5 7.03e-22 Gestational age at birth (maternal effect); CRC cis rs739401 0.611 rs2239900 chr11:3030992 C/T cg25174290 chr11:3078921 CARS 0.43 6.58 0.34 1.81e-10 Longevity; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg09584155 chr16:25026271 ARHGAP17 0.41 6.08 0.32 3.4e-9 Intelligence (multi-trait analysis); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg02996269 chr4:106394692 PPA2 0.43 6.38 0.33 6.11e-10 Intelligence (multi-trait analysis); CRC cis rs1401999 0.690 rs6773408 chr3:183716609 G/T cg20387954 chr3:183756860 HTR3D 0.37 6.35 0.33 7.1e-10 Anterior chamber depth; CRC cis rs8072100 1.000 rs4794016 chr17:45725931 T/A cg08085267 chr17:45401833 C17orf57 0.65 10.59 0.5 9.77e-23 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs10504229 1.000 rs67105789 chr8:58192002 G/T cg24829409 chr8:58192753 C8orf71 -0.68 -11.34 -0.53 2.27e-25 Developmental language disorder (linguistic errors); CRC cis rs1862618 0.529 rs978406 chr5:56259808 A/T cg20203395 chr5:56204925 C5orf35 0.73 8.94 0.44 2.85e-17 Initial pursuit acceleration; CRC cis rs2108622 0.701 rs3093209 chr19:15988420 G/C cg13772218 chr19:15982569 NA 0.48 6.75 0.35 6.72e-11 Circulating phylloquinone levels;Vitamin E levels;Acenocoumarol maintenance dosage;Response to Vitamin E supplementation;Metabolite levels;Warfarin maintenance dose; CRC cis rs6762 0.550 rs8672 chr11:838634 C/G cg15787769 chr11:842744 TSPAN4;POLR2L -0.45 -6.39 -0.33 5.8e-10 Mean platelet volume; CRC cis rs2976388 0.578 rs3736010 chr8:143817503 T/C cg24046110 chr8:143859143 LYNX1 -0.43 -6.55 -0.34 2.2e-10 Urinary tract infection frequency; CRC cis rs6500602 0.653 rs3747579 chr16:4445327 A/G cg08645402 chr16:4508243 NA -0.56 -9.14 -0.45 6.57e-18 Schizophrenia; CRC cis rs1448094 0.967 rs2121892 chr12:86324556 G/T cg19622623 chr12:86230825 RASSF9 -0.35 -5.69 -0.3 2.8e-8 Major depressive disorder; CRC cis rs10504229 0.516 rs60398072 chr8:58086559 G/A cg11062466 chr8:58055876 NA 0.48 8.45 0.42 9.35e-16 Developmental language disorder (linguistic errors); CRC cis rs7914558 0.901 rs35525740 chr10:104941112 A/T cg04362960 chr10:104952993 NT5C2 0.59 8.75 0.43 1.11e-16 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs9527 0.590 rs11191547 chr10:104843148 C/T cg15744005 chr10:104629667 AS3MT -0.3 -5.87 -0.31 1.05e-8 Arsenic metabolism; CRC cis rs9463078 0.605 rs9472409 chr6:44926431 A/G cg25276700 chr6:44698697 NA 0.25 6.2 0.32 1.69e-9 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; CRC trans rs10504229 0.906 rs116341227 chr8:58190532 G/C cg04077850 chr5:125800366 GRAMD3 0.37 6.26 0.33 1.23e-9 Developmental language disorder (linguistic errors); CRC cis rs7618915 0.501 rs1468638 chr3:52748058 T/C cg08222913 chr3:52553049 STAB1 -0.33 -6.12 -0.32 2.64e-9 Bipolar disorder; CRC trans rs7267979 0.966 rs2261795 chr20:25263136 T/C cg17903999 chr18:56338584 MALT1 -0.42 -6.98 -0.36 1.63e-11 Liver enzyme levels (alkaline phosphatase); CRC cis rs11190604 1.000 rs11190602 chr10:102297256 T/C cg16342193 chr10:102329863 NA -0.36 -5.95 -0.31 6.71e-9 Palmitoleic acid (16:1n-7) levels; CRC cis rs875971 0.545 rs316306 chr7:65618674 G/A cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.6 -7.81 -0.4 7.92e-14 Aortic root size; CRC cis rs9611565 0.512 rs139566 chr22:42199277 A/G cg03806693 chr22:41940476 POLR3H -1.08 -13.31 -0.59 1.28e-32 Vitiligo; CRC cis rs919433 0.750 rs788010 chr2:198230949 T/C cg10820045 chr2:198174542 NA 0.45 7.89 0.4 4.58e-14 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC cis rs7666738 0.830 rs13121766 chr4:98935766 A/C cg05340658 chr4:99064831 C4orf37 0.58 8.76 0.43 1.04e-16 Colonoscopy-negative controls vs population controls; CRC cis rs9658691 0.920 rs36206197 chr10:90748602 G/A cg03111039 chr10:90751583 FAS;ACTA2 -0.87 -6.3 -0.33 9.41e-10 Mosquito bite size; CRC cis rs524281 0.814 rs1055615 chr11:65846922 C/G cg14036092 chr11:66035641 RAB1B -0.5 -6.25 -0.33 1.24e-9 Electroencephalogram traits; CRC cis rs921968 0.529 rs6729341 chr2:219611434 T/G cg02176678 chr2:219576539 TTLL4 -0.39 -6.32 -0.33 8.72e-10 Mean corpuscular hemoglobin concentration; CRC cis rs13191362 0.935 rs35100164 chr6:162963003 T/C cg23758597 chr6:163146217 PARK2 -0.55 -5.62 -0.3 4.13e-8 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs7739232 0.749 rs76994901 chr6:53528523 T/C cg15658676 chr6:53530538 KLHL31 -0.76 -5.9 -0.31 8.9e-9 Hip circumference adjusted for BMI; CRC cis rs977987 0.872 rs4888422 chr16:75470576 A/G cg03315344 chr16:75512273 CHST6 0.55 9.36 0.46 1.24e-18 Dupuytren's disease; CRC cis rs9916302 0.904 rs8079303 chr17:37530755 G/C cg15445000 chr17:37608096 MED1 -0.44 -9.91 -0.48 1.93e-20 Glomerular filtration rate (creatinine); CRC cis rs1018836 0.545 rs7840203 chr8:91701223 A/G cg16814680 chr8:91681699 NA -0.98 -21.12 -0.76 3.63e-63 Ejection fraction in Tripanosoma cruzi seropositivity; CRC cis rs11105298 0.891 rs4842664 chr12:89938030 G/A cg00757033 chr12:89920650 WDR51B 0.39 6.31 0.33 9.19e-10 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; CRC cis rs172166 0.652 rs476167 chr6:28065888 T/C cg10876282 chr6:28092338 ZSCAN16 0.5 6.72 0.35 7.89e-11 Cardiac Troponin-T levels; CRC cis rs1218582 0.772 rs2102423 chr1:154916068 A/G cg16680214 chr1:154839983 KCNN3 -0.44 -8.51 -0.42 6.33e-16 Prostate cancer; CRC cis rs6500395 0.963 rs6500404 chr16:48690083 C/T cg04672837 chr16:48644449 N4BP1 -0.45 -6.63 -0.34 1.38e-10 Response to tocilizumab in rheumatoid arthritis; CRC cis rs28386778 0.897 rs2727290 chr17:61894728 G/T cg23090583 chr17:61904693 PSMC5;FTSJ3 1.05 20.68 0.75 1.83e-61 Prudent dietary pattern; CRC cis rs12477438 0.501 rs12613624 chr2:99732741 A/G cg14399236 chr2:99771627 LIPT1;TSGA10 -0.74 -12.18 -0.56 2e-28 Chronic sinus infection; CRC cis rs1580019 0.523 rs13236410 chr7:32690663 G/A cg07520158 chr7:32535189 LSM5;AVL9 0.5 7.08 0.36 8.97e-12 Cognitive ability; CRC cis rs3858526 0.883 rs4758183 chr11:5925178 C/G cg05234568 chr11:5960015 NA -0.53 -7.16 -0.37 5.31e-12 DNA methylation (variation); CRC cis rs116095464 0.558 rs13354585 chr5:242263 G/C cg22496380 chr5:211416 CCDC127 -0.9 -10.29 -0.49 1.01e-21 Breast cancer; CRC cis rs7799006 0.723 rs2270052 chr7:2291399 C/T cg08027265 chr7:2291960 NA -0.45 -7.48 -0.38 6.79e-13 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC trans rs7829975 0.593 rs2921051 chr8:8320104 C/A cg16141378 chr3:129829833 LOC729375 -0.51 -7.81 -0.4 7.99e-14 Mood instability; CRC cis rs116095464 0.558 rs10060089 chr5:205565 G/A cg22496380 chr5:211416 CCDC127 -0.95 -9.33 -0.46 1.66e-18 Breast cancer; CRC cis rs7666738 0.753 rs2865957 chr4:99040725 G/A cg05340658 chr4:99064831 C4orf37 0.58 9.01 0.44 1.7e-17 Colonoscopy-negative controls vs population controls; CRC cis rs7119 0.635 rs867916 chr15:77882860 A/G cg27398640 chr15:77910606 LINGO1 0.44 7.64 0.39 2.35e-13 Type 2 diabetes; CRC cis rs3806843 0.607 rs246044 chr5:140330656 C/T cg19875535 chr5:140030758 IK 0.39 6.02 0.31 4.67e-9 Depressive symptoms (multi-trait analysis); CRC cis rs9549367 0.713 rs576463 chr13:113846614 C/T cg00898013 chr13:113819073 PROZ 0.5 7.43 0.38 9.39e-13 Platelet distribution width; CRC cis rs9479482 1.000 rs9479405 chr6:150338065 G/A cg25797454 chr6:150327115 RAET1K 0.37 6.45 0.34 3.96e-10 Alopecia areata; CRC cis rs10152831 1 rs10152831 chr15:91059190 C/T cg04176472 chr15:90893244 GABARAPL3 0.55 7.88 0.4 4.85e-14 Neutrophil percentage of white cells; CRC trans rs1814175 0.645 rs1851845 chr11:49982396 C/T cg03929089 chr4:120376271 NA -0.91 -16.17 -0.67 1.06e-43 Height; CRC cis rs881375 0.867 rs6478487 chr9:123672777 C/T cg14255062 chr9:123606675 PSMD5;LOC253039 0.41 6.02 0.32 4.59e-9 Rheumatoid arthritis; CRC cis rs7932354 0.502 rs7118546 chr11:47087128 C/G cg03339077 chr11:47165057 C11orf49 0.44 6.16 0.32 2.18e-9 Bone mineral density (hip);Bone mineral density; CRC cis rs847577 0.609 rs11763970 chr7:97817321 A/G cg21770322 chr7:97807741 LMTK2 0.83 18.32 0.71 3.53e-52 Breast cancer; CRC cis rs362272 0.524 rs2749781 chr4:3346617 T/C cg02993699 chr4:3415135 RGS12 -0.4 -6.61 -0.34 1.52e-10 Serum sulfate level; CRC cis rs9487051 0.768 rs435611 chr6:109527755 C/T cg21918786 chr6:109611834 NA -0.35 -5.93 -0.31 7.65e-9 Reticulocyte fraction of red cells; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg19978540 chr12:3409405 NA 0.41 6.08 0.32 3.36e-9 Intelligence (multi-trait analysis); CRC cis rs7552404 0.960 rs12085123 chr1:76149749 G/A cg10523679 chr1:76189770 ACADM 0.83 11.53 0.54 4.61e-26 Blood metabolite levels;Acylcarnitine levels; CRC cis rs1691799 0.867 rs1168311 chr12:66725912 A/C cg16791601 chr12:66731901 HELB 0.67 11.54 0.54 4.41e-26 White blood cell count (basophil); CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg00098112 chr12:42631803 YAF2 0.45 6.08 0.32 3.25e-9 Anxiety disorder; CRC cis rs11628318 0.853 rs4906226 chr14:103027359 C/T cg12046867 chr14:103022105 NA -0.83 -11.62 -0.54 2.25e-26 Platelet count; CRC cis rs7666738 0.830 rs35276471 chr4:99068691 A/T cg17366294 chr4:99064904 C4orf37 0.43 7.32 0.37 1.87e-12 Colonoscopy-negative controls vs population controls; CRC cis rs2836950 0.565 rs2836943 chr21:40592611 C/T cg17971929 chr21:40555470 PSMG1 -0.62 -9.06 -0.45 1.15e-17 Menarche (age at onset); CRC cis rs849898 1 rs849898 chr1:228153917 A/G cg02753203 chr1:228287806 NA -0.81 -11.32 -0.53 2.64e-25 Parkinson's disease; CRC trans rs10982213 0.830 rs2274163 chr9:117188714 C/T cg07312579 chr9:35096654 PIGO 0.4 6.04 0.32 4.21e-9 Interleukin-6 levels; CRC cis rs12701220 0.894 rs10257744 chr7:1045612 C/T cg02733842 chr7:1102375 C7orf50 -0.84 -10.05 -0.48 6.63e-21 Bronchopulmonary dysplasia; CRC cis rs17711722 0.675 rs6947132 chr7:65273495 G/A cg02869306 chr7:64672164 INTS4L1 0.34 5.63 0.3 3.96e-8 Calcium levels; CRC cis rs4803468 1.000 rs2241708 chr19:41912270 C/T cg09537434 chr19:41945824 ATP5SL -0.92 -18.32 -0.71 3.68e-52 Height; CRC cis rs2116941 0.523 rs17000211 chr19:10369086 C/T cg01850179 chr19:10340795 S1PR2 0.54 6.76 0.35 6.34e-11 Pulse pressure; CRC cis rs1577917 0.655 rs12203963 chr6:86223316 T/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A 0.48 6.8 0.35 4.99e-11 Response to antipsychotic treatment; CRC cis rs7208859 0.623 rs55814012 chr17:29077697 T/A cg13385521 chr17:29058706 SUZ12P 0.72 8.25 0.41 3.88e-15 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs9611565 0.694 rs5758365 chr22:41858657 A/G cg03806693 chr22:41940476 POLR3H 1.08 14.62 0.63 1.25e-37 Vitiligo; CRC cis rs12908161 1.000 rs58416181 chr15:85264461 G/A cg11189052 chr15:85197271 WDR73 0.6 8.54 0.43 5.17e-16 Schizophrenia; CRC cis rs9900062 0.546 rs2676294 chr17:62710764 A/G cg02598441 chr17:62777298 LOC146880 0.53 7.09 0.36 8.29e-12 QT interval; CRC cis rs6860806 0.695 rs6867282 chr5:131583120 G/C cg18758796 chr5:131593413 PDLIM4 0.44 8.13 0.41 8.61e-15 Breast cancer; CRC cis rs2949837 0.581 rs924140 chr7:45963114 C/T cg06713098 chr7:45960367 IGFBP3 0.42 6.69 0.35 9.85e-11 Sitting height ratio; CRC cis rs780096 0.526 rs809058 chr2:27616790 T/C cg12000995 chr2:27665139 KRTCAP3 -0.3 -6.17 -0.32 2.04e-9 Total body bone mineral density; CRC cis rs9549328 0.565 rs36145949 chr13:113616608 T/C cg25790453 chr13:113633590 MCF2L 0.43 7.55 0.38 4.25e-13 Systolic blood pressure; CRC cis rs7618501 0.521 rs6774354 chr3:49961780 G/A cg24308560 chr3:49941425 MST1R -0.45 -7.06 -0.36 9.94e-12 Intelligence (multi-trait analysis); CRC cis rs7215564 0.818 rs1471790 chr17:78670565 C/A cg09596252 chr17:78655493 RPTOR 0.55 6.09 0.32 3.09e-9 Myopia (pathological); CRC cis rs262150 0.574 rs2730272 chr7:158798622 G/C cg10570241 chr7:158785291 NA 0.41 7.25 0.37 3.09e-12 Facial morphology (factor 20); CRC cis rs13064411 0.696 rs1486897 chr3:113215818 G/A cg10517650 chr3:113235015 CCDC52 -0.4 -6.95 -0.36 1.98e-11 Response to simvastatin treatment (PCSK9 protein level change); CRC cis rs6543140 0.964 rs6543136 chr2:103065547 G/A cg03938978 chr2:103052716 IL18RAP 0.4 6.24 0.33 1.34e-9 Blood protein levels; CRC cis rs294883 0.858 rs2879864 chr6:159712848 A/G cg14500486 chr6:159655392 FNDC1 -0.35 -5.75 -0.3 2.09e-8 Coronary artery disease; CRC cis rs875971 0.502 rs1796227 chr7:66087019 G/C cg18876405 chr7:65276391 NA -0.46 -6.32 -0.33 8.27e-10 Aortic root size; CRC cis rs7737355 0.755 rs12519233 chr5:130960093 C/A cg06307176 chr5:131281290 NA 0.45 6.45 0.34 3.91e-10 Life satisfaction; CRC cis rs2839186 0.632 rs17176110 chr21:47706535 C/A cg12516959 chr21:47718080 NA -0.4 -6.7 -0.35 8.83e-11 Testicular germ cell tumor; CRC cis rs62064224 0.530 rs8073708 chr17:30680493 T/C cg18200150 chr17:30822561 MYO1D 0.44 8.61 0.43 3.07e-16 Schizophrenia; CRC trans rs2303319 0.504 rs62189051 chr2:162622318 G/A cg25193742 chr10:104614220 C10orf32 -0.76 -6.46 -0.34 3.66e-10 Cognitive function; CRC cis rs4805272 0.539 rs17591634 chr19:29331628 A/C cg12667521 chr19:29218732 NA -0.42 -5.71 -0.3 2.57e-8 Plasma omega-3 polyunsaturated fatty acid levels (docosahexaenoic acid); CRC cis rs10128264 0.841 rs2790766 chr10:80960616 A/G cg20744163 chr10:80999841 ZMIZ1 0.42 7.81 0.4 7.99e-14 Response to methotrexate in juvenile idiopathic arthritis; CRC cis rs10779751 0.922 rs4845985 chr1:11288618 G/A cg08854313 chr1:11322531 MTOR 0.69 9.97 0.48 1.28e-20 Body mass index; CRC cis rs801193 0.901 rs4273746 chr7:66301111 C/T cg11764359 chr7:65958608 NA -0.54 -8.06 -0.41 1.45e-14 Aortic root size; CRC cis rs798554 0.757 rs1182188 chr7:2869985 T/C cg13628971 chr7:2884303 GNA12 0.5 6.78 0.35 5.6e-11 Height; CRC cis rs7811142 0.943 rs66958101 chr7:100074020 G/A cg00814883 chr7:100076585 TSC22D4 -0.75 -9.49 -0.46 4.87e-19 Platelet count; CRC cis rs10242455 0.702 rs2293256 chr7:99057701 A/G cg18809830 chr7:99032528 PTCD1 0.92 6.98 0.36 1.66e-11 Blood metabolite levels; CRC trans rs10982213 0.830 rs2274163 chr9:117188714 C/T cg02096607 chr11:27493868 LGR4 0.33 6.11 0.32 2.83e-9 Interleukin-6 levels; CRC cis rs10876993 0.890 rs10783844 chr12:58098425 A/C cg15848620 chr12:58087721 OS9 -0.63 -8.94 -0.44 2.88e-17 Celiac disease or Rheumatoid arthritis; CRC cis rs728616 0.867 rs17096197 chr10:81808184 T/C cg11900509 chr10:81946545 ANXA11 -0.57 -6.19 -0.32 1.77e-9 Chronic obstructive pulmonary disease-related biomarkers; CRC trans rs2303319 0.504 rs55782047 chr2:162440255 A/C cg12500891 chr11:57225987 NA -0.67 -6.03 -0.32 4.42e-9 Cognitive function; CRC cis rs2836950 0.545 rs2836959 chr21:40623668 T/G cg11890956 chr21:40555474 PSMG1 -0.68 -10.19 -0.49 2.27e-21 Menarche (age at onset); CRC cis rs3018066 0.748 rs12510966 chr4:106983604 A/G cg01869342 chr4:106983673 TBCK 0.46 6.76 0.35 6.35e-11 Cancer; CRC trans rs2018683 0.899 rs10479817 chr7:28978148 A/C cg19402173 chr7:128379420 CALU -0.54 -8.23 -0.41 4.31e-15 Response to irinotecan and platinum-based chemotherapy in non-small-cell lung cancer; CRC cis rs2243480 1.000 rs34815098 chr7:65292254 A/C cg18252515 chr7:66147081 NA -1.17 -13.55 -0.6 1.59e-33 Diabetic kidney disease; CRC cis rs1552244 0.832 rs66597916 chr3:10195407 T/C cg16606324 chr3:10149918 C3orf24 0.62 7.1 0.36 7.6e-12 Alzheimer's disease; CRC cis rs4660306 0.961 rs1337902 chr1:45952066 G/A cg03123370 chr1:45965343 CCDC163P;MMACHC -0.56 -7.85 -0.4 5.99e-14 Homocysteine levels; CRC cis rs875971 0.545 rs2707851 chr7:66089165 C/T cg11764359 chr7:65958608 NA -0.46 -5.79 -0.3 1.65e-8 Aortic root size; CRC cis rs11098499 0.866 rs13105020 chr4:120285688 G/T cg09307838 chr4:120376055 NA 0.68 10.54 0.5 1.45e-22 Corneal astigmatism; CRC cis rs2282802 0.651 rs6863474 chr5:139630862 C/T cg26211634 chr5:139558579 C5orf32 0.41 7.12 0.37 6.97e-12 Intelligence (multi-trait analysis); CRC cis rs853679 0.607 rs201002 chr6:27808192 A/G cg03623178 chr6:28175578 NA 0.75 6.63 0.34 1.39e-10 Depression; CRC trans rs12478296 0.786 rs28802397 chr2:243049730 G/A cg18288967 chr1:45987694 PRDX1 0.67 7.43 0.38 9.3e-13 Obesity-related traits; CRC cis rs17155006 0.655 rs448742 chr7:107733993 C/T cg05962710 chr7:107745446 LAMB4 0.36 6.14 0.32 2.38e-9 Pneumococcal bacteremia; CRC cis rs7043114 0.525 rs6479419 chr9:95110002 T/C cg13798575 chr9:95087839 CENPP;NOL8 -0.39 -5.83 -0.31 1.36e-8 Height; CRC cis rs4243830 0.737 rs4908909 chr1:6599041 C/T cg22792644 chr1:6614718 TAS1R1;NOL9 -0.69 -7.76 -0.39 1.08e-13 Body mass index; CRC cis rs7617773 0.817 rs9837228 chr3:48324466 A/T cg11946769 chr3:48343235 NME6 -0.64 -8.84 -0.44 5.78e-17 Coronary artery disease; CRC cis rs10504229 0.639 rs2318146 chr8:58114873 T/G cg22535103 chr8:58192502 C8orf71 -0.69 -9.23 -0.45 3.37e-18 Developmental language disorder (linguistic errors); CRC cis rs7312933 0.526 rs1669892 chr12:42811305 G/A cg11827402 chr12:42719852 PPHLN1;ZCRB1 -0.66 -9.74 -0.47 7.31e-20 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CRC cis rs9648716 1.000 rs1267634 chr7:140490382 C/T cg10747023 chr7:140774559 NA 0.44 5.67 0.3 3.1e-8 Type 2 diabetes; CRC cis rs6545883 0.965 rs2305156 chr2:61729268 T/C cg15711740 chr2:61764176 XPO1 -0.51 -7.12 -0.37 6.68e-12 Tuberculosis; CRC cis rs3858526 0.833 rs4758184 chr11:5926719 A/G cg05234568 chr11:5960015 NA -0.53 -7.26 -0.37 2.82e-12 DNA methylation (variation); CRC cis rs2710247 1 rs2710247 chr2:219467508 A/G cg02176678 chr2:219576539 TTLL4 0.49 7.86 0.4 5.61e-14 Lobe attachment (rater-scored or self-reported); CRC cis rs11098499 0.754 rs1814813 chr4:120258207 G/T cg24375607 chr4:120327624 NA -0.46 -7.12 -0.37 6.83e-12 Corneal astigmatism; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg22715954 chr12:58146426 CDK4 0.46 6.79 0.35 5.31e-11 Intelligence (multi-trait analysis); CRC cis rs7487075 0.619 rs12822345 chr12:46834677 G/C cg22049899 chr12:47219821 SLC38A4 0.32 5.78 0.3 1.77e-8 Itch intensity from mosquito bite; CRC cis rs801193 1.000 rs2707854 chr7:66212597 G/A cg05627663 chr7:65219948 SNORA22;CCT6P1 0.42 6.12 0.32 2.65e-9 Aortic root size; CRC trans rs948562 0.947 rs11541682 chr11:58385752 T/C cg26660744 chr1:1573181 CDK11B 0.54 6.1 0.32 2.94e-9 Lymphoma; CRC cis rs7587476 0.682 rs13009646 chr2:215691259 T/A cg04004882 chr2:215674386 BARD1 0.66 9.21 0.45 3.84e-18 Neuroblastoma; CRC cis rs1862618 0.853 rs252921 chr5:56137787 G/A cg22800045 chr5:56110881 MAP3K1 0.56 6.15 0.32 2.29e-9 Initial pursuit acceleration; CRC cis rs2976388 0.609 rs1560986 chr8:143789775 T/C cg22687807 chr8:143858763 LYNX1 0.49 8.92 0.44 3.32e-17 Urinary tract infection frequency; CRC cis rs10512697 0.655 rs13171097 chr5:3512130 G/A cg19473799 chr5:3511975 NA -0.83 -6.34 -0.33 7.66e-10 Immune response to smallpox vaccine (IL-6); CRC cis rs10426930 0.752 rs56249413 chr19:5036730 G/A cg18473234 chr19:5097819 KDM4B 0.47 5.84 0.31 1.22e-8 Monocyte percentage of white cells; CRC cis rs5167 0.566 rs204905 chr19:45460764 G/A cg13119609 chr19:45449297 APOC2 0.36 6.61 0.34 1.58e-10 Blood protein levels; CRC cis rs67478160 0.608 rs11160760 chr14:104248938 G/T cg08213375 chr14:104286397 PPP1R13B 0.65 13.5 0.6 2.46e-33 Schizophrenia; CRC cis rs8180040 0.726 rs7628747 chr3:47001990 A/T cg27129171 chr3:47204927 SETD2 0.64 9.87 0.48 2.67e-20 Colorectal cancer; CRC cis rs10791323 0.569 rs2187450 chr11:133743792 A/G cg06766960 chr11:133703094 NA -0.35 -6.44 -0.33 4.33e-10 Childhood ear infection; CRC cis rs9300255 0.602 rs2695479 chr12:123689386 T/C cg00376283 chr12:123451042 ABCB9 0.58 6.85 0.35 3.66e-11 Neutrophil percentage of white cells; CRC cis rs9322193 0.923 rs35830138 chr6:149989771 T/C cg07701084 chr6:150067640 NUP43 0.56 8.15 0.41 7.93e-15 Lung cancer; CRC cis rs6121246 0.567 rs6120815 chr20:30184866 T/C cg13852791 chr20:30311386 BCL2L1 0.6 8.21 0.41 5.04e-15 Mean corpuscular hemoglobin; CRC trans rs9291683 0.530 rs998675 chr4:9948829 A/G cg26043149 chr18:55253948 FECH 0.55 8.26 0.41 3.67e-15 Bone mineral density; CRC cis rs4964805 0.594 rs4981036 chr12:104164344 C/G cg02344784 chr12:104178138 NT5DC3 0.47 7.2 0.37 4.06e-12 Attention deficit hyperactivity disorder; CRC cis rs3741404 0.825 rs11603538 chr11:63986713 C/A cg19465662 chr11:63993652 NUDT22;TRPT1 0.84 14.05 0.61 1.83e-35 Platelet count; CRC cis rs8072100 0.840 rs9893901 chr17:45506682 T/G cg08085267 chr17:45401833 C17orf57 -0.66 -10.75 -0.51 2.65e-23 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs9788333 0.695 rs12871086 chr13:21890224 A/T cg25811766 chr13:21894605 NA 0.68 10.89 0.51 8.31e-24 Thiazide-induced adverse metabolic effects in hypertensive patients; CRC cis rs116095464 0.558 rs59284383 chr5:284525 C/G cg22496380 chr5:211416 CCDC127 -0.89 -10.1 -0.49 4.58e-21 Breast cancer; CRC cis rs12701220 0.553 rs9639882 chr7:1133731 G/A cg02733842 chr7:1102375 C7orf50 -0.61 -7.5 -0.38 6e-13 Bronchopulmonary dysplasia; CRC cis rs4713118 0.629 rs203888 chr6:28021589 C/T cg15786705 chr6:28176104 NA 0.7 10.11 0.49 4.3e-21 Parkinson's disease; CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg04590956 chr2:70057467 GMCL1 -0.5 -6.02 -0.31 4.55e-9 Diisocyanate-induced asthma; CRC cis rs6674176 0.542 rs803679 chr1:44349405 G/A cg12908607 chr1:44402522 ARTN -0.42 -6.85 -0.35 3.64e-11 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Cognitive ability; CRC cis rs921968 0.542 rs630858 chr2:219409689 C/A cg02176678 chr2:219576539 TTLL4 0.55 8.68 0.43 1.88e-16 Mean corpuscular hemoglobin concentration; CRC cis rs853679 0.517 rs2281588 chr6:28072602 G/A cg21251018 chr6:28226885 NKAPL 0.48 6.22 0.32 1.55e-9 Depression; CRC cis rs6598955 0.724 rs12757113 chr1:26597144 C/T cg04990556 chr1:26633338 UBXN11 -0.77 -12.6 -0.57 5.8e-30 Obesity-related traits; CRC cis rs7849270 0.879 rs7859344 chr9:131848382 T/A cg13538475 chr9:131942899 NA -0.3 -5.76 -0.3 1.97e-8 Blood metabolite ratios; CRC cis rs11148252 0.740 rs9536046 chr13:52955899 T/G cg02158880 chr13:53174818 NA 0.45 6.34 0.33 7.77e-10 Lewy body disease; CRC cis rs7829975 0.711 rs12682352 chr8:8646246 A/G cg08975724 chr8:8085496 FLJ10661 0.41 6.58 0.34 1.81e-10 Mood instability; CRC trans rs1814175 0.817 rs10839465 chr11:49981554 C/A cg21153622 chr11:89784906 NA -0.37 -5.97 -0.31 6.05e-9 Height; CRC cis rs10540 0.908 rs71487293 chr11:486414 G/A cg03352830 chr11:487213 PTDSS2 0.65 7.3 0.37 2.16e-12 Body mass index; CRC cis rs17095355 1.000 rs752584 chr10:111682934 C/G cg00817464 chr10:111662876 XPNPEP1 -0.54 -6.17 -0.32 1.97e-9 Biliary atresia; CRC cis rs17270561 0.609 rs1317816 chr6:25765390 T/C cg16482183 chr6:26056742 HIST1H1C 0.71 9.0 0.44 1.79e-17 Iron status biomarkers; CRC cis rs4654899 0.758 rs6426667 chr1:21396216 C/A cg02927042 chr1:21476669 EIF4G3 -0.39 -6.2 -0.32 1.7e-9 Superior frontal gyrus grey matter volume; CRC cis rs13108904 0.870 rs12642797 chr4:1245990 G/A cg00684032 chr4:1343700 KIAA1530 0.45 6.79 0.35 5.3e-11 Obesity-related traits; CRC cis rs754466 0.580 rs2579178 chr10:79529215 A/G cg17075019 chr10:79541650 NA 0.94 16.95 0.68 9.02e-47 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs17095355 1.000 rs2419313 chr10:111750851 G/A cg00817464 chr10:111662876 XPNPEP1 -0.58 -7.75 -0.39 1.12e-13 Biliary atresia; CRC cis rs12893668 0.572 rs11540512 chr14:104147377 C/T cg01849466 chr14:104193079 ZFYVE21 -0.4 -5.91 -0.31 8.68e-9 Reticulocyte count; CRC cis rs7586879 0.828 rs13012304 chr2:25122246 C/T cg04586622 chr2:25135609 ADCY3 -0.57 -9.65 -0.47 1.41e-19 Body mass index; CRC cis rs651907 0.557 rs7651404 chr3:101393294 C/A cg11279151 chr3:101281821 RG9MTD1 -0.57 -7.74 -0.39 1.25e-13 Colorectal cancer; CRC trans rs1814175 0.565 rs4881721 chr11:49761851 G/A cg03929089 chr4:120376271 NA -0.77 -12.84 -0.58 7.46e-31 Height; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg02010776 chr16:18938091 SMG1 0.44 6.24 0.33 1.37e-9 Intelligence (multi-trait analysis); CRC trans rs7937682 0.774 rs59921976 chr11:111473088 G/A cg18187862 chr3:45730750 SACM1L 0.46 6.58 0.34 1.83e-10 Primary sclerosing cholangitis; CRC cis rs12620999 0.555 rs10199274 chr2:238111864 G/C cg23555395 chr2:238036564 NA -0.37 -5.77 -0.3 1.84e-8 Systemic lupus erythematosus; CRC cis rs938554 0.784 rs1071988 chr4:9974638 A/G cg11266682 chr4:10021025 SLC2A9 -0.35 -5.63 -0.3 3.78e-8 Blood metabolite levels; CRC cis rs6121246 0.583 rs28815498 chr20:30351560 T/C cg13852791 chr20:30311386 BCL2L1 0.78 15.32 0.65 2.24e-40 Mean corpuscular hemoglobin; CRC cis rs2204008 0.837 rs11172728 chr12:38070042 C/A cg13010199 chr12:38710504 ALG10B 0.46 6.1 0.32 3.03e-9 Bladder cancer; CRC trans rs35110281 0.667 rs4819287 chr21:45120147 A/G cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.44 6.94 0.36 2.11e-11 Mean corpuscular volume; CRC cis rs72799341 1.000 rs1458201 chr16:30916129 G/A cg02466173 chr16:30829666 NA -0.71 -8.71 -0.43 1.52e-16 Diastolic blood pressure; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg24508409 chr1:112298175 DDX20;C1orf183 0.41 6.71 0.35 8.69e-11 Liver disease severity in Alagille syndrome; CRC cis rs477692 1.000 rs530466 chr10:131427717 A/G cg26102564 chr10:131424627 MGMT 0.37 5.67 0.3 3.19e-8 Response to temozolomide; CRC cis rs6424115 0.830 rs2502991 chr1:24202318 A/G cg10978503 chr1:24200527 CNR2 0.61 11.06 0.52 2.22e-24 Immature fraction of reticulocytes; CRC cis rs896854 0.608 rs6991067 chr8:95875676 A/G cg09323728 chr8:95962352 TP53INP1 -0.38 -6.15 -0.32 2.21e-9 Type 2 diabetes; CRC cis rs6598955 0.724 rs10902731 chr1:26600793 A/G cg00852783 chr1:26633632 UBXN11 0.42 6.82 0.35 4.41e-11 Obesity-related traits; CRC cis rs40363 0.723 rs2736 chr16:3536872 G/A cg05754148 chr16:3507555 NAT15 -0.71 -6.78 -0.35 5.61e-11 Tuberculosis; CRC cis rs2976388 0.590 rs4736322 chr8:143822208 T/C cg22687807 chr8:143858763 LYNX1 -0.45 -7.45 -0.38 8.23e-13 Urinary tract infection frequency; CRC cis rs9443645 0.869 rs10943585 chr6:79502409 G/C cg09184832 chr6:79620586 NA -0.49 -9.19 -0.45 4.59e-18 Intelligence (multi-trait analysis); CRC cis rs10256972 0.521 rs871019 chr7:1105230 A/G cg18765753 chr7:1198926 ZFAND2A -0.34 -6.13 -0.32 2.48e-9 Longevity;Endometriosis; CRC cis rs1552244 0.554 rs3846169 chr3:9997054 A/G cg16606324 chr3:10149918 C3orf24 -0.45 -6.9 -0.36 2.63e-11 Alzheimer's disease; CRC cis rs1150668 0.796 rs1124132 chr6:28380321 T/G cg06470822 chr6:28175283 NA 0.62 9.21 0.45 3.81e-18 Pubertal anthropometrics; CRC cis rs11628318 0.617 rs11626481 chr14:103086356 A/G cg23071808 chr14:103021642 NA -0.64 -7.27 -0.37 2.72e-12 Platelet count; CRC cis rs4481887 1.000 rs6659039 chr1:248465689 C/T cg00666640 chr1:248458726 OR2T12 0.52 9.14 0.45 6.57e-18 Common traits (Other); CRC cis rs7945718 0.806 rs11022507 chr11:12829753 A/T cg25843174 chr11:12811716 TEAD1 0.51 9.61 0.47 1.93e-19 Educational attainment (years of education); CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg03311606 chr2:173292277 ITGA6 0.48 6.11 0.32 2.89e-9 Thyroid stimulating hormone; CRC cis rs752010 0.714 rs6658500 chr1:42088344 A/G cg06885757 chr1:42089581 HIVEP3 -0.49 -8.73 -0.43 1.28e-16 Lupus nephritis in systemic lupus erythematosus; CRC cis rs929354 1.000 rs1182377 chr7:157048403 T/C cg17757837 chr7:157058334 UBE3C -0.87 -16.91 -0.68 1.34e-46 Body mass index; CRC cis rs7615952 0.599 rs1875683 chr3:125732481 C/G cg15145296 chr3:125709740 NA -0.6 -7.07 -0.36 9.42e-12 Blood pressure (smoking interaction); CRC cis rs727479 0.543 rs6493488 chr15:51513922 G/C cg19946085 chr15:51559439 CYP19A1 -0.29 -5.73 -0.3 2.29e-8 Estradiol levels; CRC cis rs66887589 0.627 rs3872807 chr4:120360251 T/A cg09307838 chr4:120376055 NA 0.54 8.42 0.42 1.15e-15 Diastolic blood pressure; CRC cis rs35110281 0.806 rs1454649 chr21:45032982 C/T cg04455712 chr21:45112962 RRP1B 0.4 7.95 0.4 3.07e-14 Mean corpuscular volume; CRC cis rs7615952 0.641 rs7640158 chr3:125808011 G/A cg02772935 chr3:125709198 NA -0.5 -5.81 -0.3 1.5e-8 Blood pressure (smoking interaction); CRC cis rs2836974 0.897 rs2836932 chr21:40546717 G/A cg11890956 chr21:40555474 PSMG1 1.08 18.6 0.72 2.69e-53 Cognitive function; CRC cis rs2153535 0.580 rs1577466 chr6:8444192 T/C cg21535247 chr6:8435926 SLC35B3 0.47 7.12 0.37 6.79e-12 Motion sickness; CRC cis rs4689388 0.890 rs4688989 chr4:6290594 T/C cg25554036 chr4:6271136 WFS1 0.54 8.69 0.43 1.78e-16 Type 2 diabetes and other traits;Type 2 diabetes; CRC cis rs1552244 0.882 rs34779351 chr3:10021801 A/G cg18598329 chr3:10140678 FANCD2;C3orf24 -0.81 -10.69 -0.51 4.18e-23 Alzheimer's disease; CRC cis rs6684514 1.000 rs10908498 chr1:156278175 T/C cg16558208 chr1:156270281 VHLL 0.56 8.8 0.44 7.83e-17 Mean corpuscular hemoglobin concentration;Glycated hemoglobin levels; CRC cis rs2228479 0.717 rs11649210 chr16:89807233 C/G cg19635926 chr16:89946313 TCF25 0.64 6.43 0.33 4.43e-10 Skin colour saturation; CRC cis rs2011503 1.000 rs75667002 chr19:19592232 T/A cg11584989 chr19:19387371 SF4 0.54 6.1 0.32 2.99e-9 Bipolar disorder; CRC trans rs2303319 0.504 rs12473497 chr2:162433766 T/C cg18122310 chr12:50236657 BCDIN3D -0.75 -6.24 -0.33 1.33e-9 Cognitive function; CRC cis rs6001027 0.540 rs1005529 chr22:38541266 T/C cg03162506 chr22:38580953 NA 0.26 5.68 0.3 2.93e-8 Melanoma; CRC cis rs3617 0.625 rs11922961 chr3:52868610 T/C cg07507251 chr3:52567010 NT5DC2 -0.41 -6.31 -0.33 9.17e-10 Red blood cell count;Autism spectrum disorder or schizophrenia; CRC trans rs6544773 0.587 rs341580 chr2:45056311 C/G cg10208897 chr5:178548229 ADAMTS2 0.35 6.04 0.32 4.12e-9 Mosquito bite size; CRC cis rs71403859 0.504 rs35203704 chr16:71959661 G/A cg03805757 chr16:71968109 PKD1L3 -0.65 -5.65 -0.3 3.48e-8 Post bronchodilator FEV1; CRC cis rs66573146 0.572 rs68169399 chr4:6952491 T/A cg00086871 chr4:6988644 TBC1D14 0.93 8.92 0.44 3.4e-17 Granulocyte percentage of myeloid white cells; CRC cis rs34779708 0.931 rs2505631 chr10:35368385 A/T cg03585969 chr10:35415529 CREM -0.55 -7.4 -0.38 1.13e-12 Inflammatory bowel disease;Crohn's disease; CRC cis rs4654899 0.865 rs72975078 chr1:21476196 A/G cg02927042 chr1:21476669 EIF4G3 -0.5 -7.83 -0.4 6.59e-14 Superior frontal gyrus grey matter volume; CRC cis rs1552244 0.882 rs13064570 chr3:9997545 G/C cg08888203 chr3:10149979 C3orf24 0.62 8.34 0.42 2.14e-15 Alzheimer's disease; CRC cis rs9372498 0.505 rs9320655 chr6:118830981 T/C cg10217327 chr6:118973057 C6orf204 0.51 5.81 0.3 1.5e-8 Diastolic blood pressure; CRC cis rs2243480 1.000 rs316318 chr7:65612904 A/G cg12463550 chr7:65579703 CRCP 0.74 6.66 0.34 1.14e-10 Diabetic kidney disease; CRC cis rs6459788 0.934 rs10251462 chr7:157258183 C/G cg06271696 chr7:157225062 NA -0.39 -6.72 -0.35 8.08e-11 Epstein-Barr virus copy number in lymphoblastoid cell lines; CRC cis rs2576037 0.583 rs4890698 chr18:44489725 A/G cg23996704 chr18:44553084 KATNAL2 -0.36 -7.33 -0.37 1.79e-12 Personality dimensions; CRC cis rs12541335 0.639 rs11135995 chr8:22200148 C/T cg09517075 chr8:22133004 PIWIL2 -0.44 -7.5 -0.38 6.09e-13 Hypertriglyceridemia; CRC cis rs4731207 0.564 rs10270051 chr7:124649393 T/C cg23710748 chr7:124431027 NA -0.39 -6.17 -0.32 2.04e-9 Cutaneous malignant melanoma; CRC cis rs6502050 0.835 rs34867501 chr17:80121358 T/C cg22110888 chr17:80059540 CCDC57 0.4 6.38 0.33 5.96e-10 Life satisfaction; CRC cis rs9311676 0.656 rs56198078 chr3:58392224 G/C cg06643156 chr3:58380774 PXK 0.41 6.22 0.32 1.55e-9 Systemic lupus erythematosus; CRC cis rs1867631 0.585 rs9787219 chr1:67080159 G/C cg02459107 chr1:67143332 SGIP1 0.34 6.18 0.32 1.95e-9 Menopause (age at onset); CRC cis rs9549328 0.800 rs9549616 chr13:113627762 T/G cg20742385 chr13:113633654 MCF2L -0.71 -12.39 -0.56 3.47e-29 Systolic blood pressure; CRC cis rs172166 0.694 rs188105 chr6:28071393 C/T cg03623178 chr6:28175578 NA 0.8 11.88 0.55 2.41e-27 Cardiac Troponin-T levels; CRC cis rs6582630 0.555 rs10785443 chr12:38463792 A/C cg26384229 chr12:38710491 ALG10B 0.63 8.71 0.43 1.51e-16 Drug-induced liver injury (flucloxacillin); CRC cis rs6459788 0.693 rs11981578 chr7:157250133 C/T cg01766193 chr7:157202248 DNAJB6 -0.35 -5.72 -0.3 2.39e-8 Epstein-Barr virus copy number in lymphoblastoid cell lines; CRC cis rs7692995 1.000 rs73100947 chr4:18021307 C/T cg08925142 chr4:18023851 LCORL -0.51 -5.81 -0.3 1.5e-8 Height; CRC cis rs11098499 0.738 rs28687057 chr4:120280812 A/G cg24375607 chr4:120327624 NA 0.48 7.48 0.38 6.72e-13 Corneal astigmatism; CRC cis rs875971 0.862 rs2909688 chr7:65841612 C/A cg00343986 chr7:65444356 GUSB 0.45 6.2 0.32 1.68e-9 Aortic root size; CRC cis rs875971 0.545 rs3735147 chr7:65970528 A/C cg11764359 chr7:65958608 NA 0.45 5.62 0.3 4e-8 Aortic root size; CRC cis rs10901296 0.660 rs2855199 chr9:133765044 T/C cg01000188 chr9:133769184 QRFP 0.68 8.55 0.43 4.68e-16 Bilirubin levels; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg12639422 chr2:64069082 UGP2 0.45 6.4 0.33 5.29e-10 Response to antipsychotic treatment; CRC cis rs3784262 0.934 rs7164408 chr15:58259336 A/G cg12031962 chr15:58353849 ALDH1A2 -0.33 -5.7 -0.3 2.64e-8 Barrett's esophagus;Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined); CRC cis rs798554 0.610 rs2251491 chr7:2852835 T/C cg19717773 chr7:2847554 GNA12 -0.47 -8.01 -0.4 2.02e-14 Height; CRC cis rs477692 0.663 rs491929 chr10:131368111 G/A cg05714579 chr10:131428358 MGMT 0.49 6.89 0.35 2.9100000000000002e-11 Response to temozolomide; CRC cis rs546131 0.928 rs535719 chr11:34853382 A/G cg06937548 chr11:34938143 PDHX;APIP 0.42 6.4 0.33 5.26e-10 Lung disease severity in cystic fibrosis; CRC cis rs6761276 0.899 rs11678375 chr2:113835691 T/C cg24553058 chr2:113831203 IL1F10 0.4 6.44 0.33 4.26e-10 Protein quantitative trait loci; CRC cis rs12364620 1 rs12364620 chr11:68252123 T/G cg16797656 chr11:68205561 LRP5 0.39 6.17 0.32 2.02e-9 Total body bone mineral density (age 0-15); CRC cis rs6952808 0.609 rs4721190 chr7:1954732 A/G cg00106254 chr7:1943704 MAD1L1 0.42 6.58 0.34 1.82e-10 Bipolar disorder and schizophrenia; CRC cis rs595982 0.527 rs12151238 chr19:49368613 T/C cg15549821 chr19:49342101 PLEKHA4 -0.56 -6.6 -0.34 1.62e-10 Red cell distribution width; CRC cis rs9903692 0.954 rs10853094 chr17:46176062 T/C cg21215337 chr17:46176117 CBX1 -0.43 -7.95 -0.4 2.95e-14 Pulse pressure; CRC cis rs11212617 0.967 rs228592 chr11:108123189 C/A cg12106634 chr11:108092400 ATM;NPAT 0.43 6.37 0.33 6.24e-10 Response to metformin in type 2 diabetes (glycemic); CRC cis rs7726839 0.526 rs55647623 chr5:567747 T/C cg16447950 chr5:562315 NA -0.84 -13.05 -0.58 1.22e-31 Obesity-related traits; CRC cis rs7412746 0.658 rs17660092 chr1:150797748 T/C cg15448220 chr1:150897856 SETDB1 0.56 8.07 0.41 1.37e-14 Melanoma; CRC trans rs2235573 0.527 rs139886 chr22:38371328 C/T cg19894588 chr14:64061835 NA 0.52 7.65 0.39 2.23e-13 Glioblastoma;Glioma; CRC cis rs62064224 0.589 rs756785 chr17:30812845 T/C cg12855166 chr17:30846586 MYO1D -0.35 -5.78 -0.3 1.7e-8 Schizophrenia; CRC cis rs9807989 0.507 rs4851571 chr2:103019000 C/T cg03938978 chr2:103052716 IL18RAP 0.59 10.17 0.49 2.54e-21 Asthma; CRC cis rs6662572 0.737 rs11584814 chr1:46504389 G/A cg03123370 chr1:45965343 CCDC163P;MMACHC 0.46 5.94 0.31 7.27e-9 Blood protein levels; CRC cis rs7312933 0.558 rs11181403 chr12:42682902 G/A cg19980929 chr12:42632907 YAF2 0.46 6.94 0.36 2.13e-11 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CRC trans rs587242 1.000 rs7551466 chr1:96892427 G/T cg10631902 chr5:14652156 NA 0.45 6.9 0.36 2.7e-11 Body mass index (joint analysis main effects and physical activity interaction);Body mass index in physically inactive individuals;Body mass index; CRC cis rs597539 0.617 rs598353 chr11:68635770 C/A cg06028808 chr11:68637592 NA 0.41 6.67 0.35 1.07e-10 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC trans rs62103177 0.564 rs2115996 chr18:77701007 C/G cg05926928 chr17:57297772 GDPD1 1.15 10.62 0.51 7.84e-23 Opioid sensitivity; CRC cis rs9648716 0.872 rs6964937 chr7:140609690 C/G cg10747023 chr7:140774559 NA 0.49 6.3 0.33 9.42e-10 Type 2 diabetes; CRC cis rs11864453 0.826 rs2074626 chr16:72139184 C/A cg01557791 chr16:72042693 DHODH -0.48 -6.61 -0.34 1.59e-10 Fibrinogen levels; CRC cis rs8180040 0.934 rs62260710 chr3:47564462 C/G cg10298567 chr3:47292165 KIF9 0.37 5.8 0.3 1.58e-8 Colorectal cancer; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg07709635 chr12:3000034 TULP3 0.47 6.3 0.33 9.46e-10 Anxiety disorder; CRC trans rs9528384 0.724 rs7987007 chr13:62247488 T/C cg08375866 chr1:50799151 NA -0.32 -5.96 -0.31 6.47e-9 Verbal declarative memory; CRC cis rs2204008 0.806 rs1589382 chr12:38408565 T/A cg26384229 chr12:38710491 ALG10B 0.69 9.77 0.47 5.95e-20 Bladder cancer; CRC cis rs17065868 0.764 rs9533852 chr13:45019918 C/T cg10246903 chr13:45222710 NA -0.59 -6.48 -0.34 3.37e-10 Antineutrophil cytoplasmic antibody-associated vasculitis; CRC cis rs4803468 1.000 rs3810174 chr19:41904165 C/T cg09537434 chr19:41945824 ATP5SL -0.93 -18.33 -0.71 3.41e-52 Height; CRC cis rs10751667 0.666 rs7944815 chr11:959776 C/T cg01483505 chr11:975446 AP2A2 0.46 7.67 0.39 2.02e-13 Alzheimer's disease (late onset); CRC cis rs2742417 1.000 rs17328701 chr3:45734258 A/G cg04837898 chr3:45731254 SACM1L -0.34 -5.69 -0.3 2.81e-8 Response to anti-depressant treatment in major depressive disorder; CRC cis rs7258465 1.000 rs7252848 chr19:18612351 C/G cg01065977 chr19:18549689 ISYNA1 -0.37 -5.73 -0.3 2.31e-8 Breast cancer; CRC trans rs2727020 0.729 rs685789 chr11:49241228 G/A cg03929089 chr4:120376271 NA 0.81 13.39 0.59 6.42e-33 Coronary artery disease; CRC cis rs2797160 0.904 rs1739370 chr6:126011231 C/T cg05901451 chr6:126070800 HEY2 0.38 5.92 0.31 7.94e-9 Endometrial cancer; CRC cis rs2228479 0.850 rs1800355 chr16:89813194 C/T cg06656553 chr16:89960601 TCF25 -0.69 -5.74 -0.3 2.15e-8 Skin colour saturation; CRC cis rs16936870 0.571 rs7017499 chr8:71083453 A/G cg14232793 chr8:71155543 NCOA2 -0.48 -5.69 -0.3 2.75e-8 QT interval; CRC cis rs10504229 1.000 rs66886949 chr8:58187613 A/G cg24829409 chr8:58192753 C8orf71 -0.68 -11.34 -0.53 2.27e-25 Developmental language disorder (linguistic errors); CRC trans rs11105468 1.000 rs10858937 chr12:90274437 G/A cg23572944 chr11:60720130 SLC15A3 -0.43 -6.04 -0.32 4.15e-9 Febrile seizures;Febrile seizures (MMR vaccine-related);Febrile seizures (MMR vaccine-unrelated); CRC cis rs6028335 0.674 rs61213966 chr20:37621906 A/G cg16355469 chr20:37678765 NA 0.46 5.61 0.3 4.34e-8 Alcohol and nicotine co-dependence; CRC trans rs559356 0.561 rs44338 chr3:34834586 G/A cg18960307 chr17:4699574 PSMB6 0.4 6.08 0.32 3.24e-9 Cognitive function; CRC cis rs1799949 1.000 rs8176265 chr17:41213996 C/T cg01879757 chr17:41196368 BRCA1 -0.41 -6.14 -0.32 2.37e-9 Menopause (age at onset); CRC cis rs7246967 0.673 rs55744741 chr19:22959973 C/T cg08271804 chr19:22816896 ZNF492 0.38 5.85 0.31 1.2e-8 Bronchopulmonary dysplasia; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg01591470 chr14:39736043 CTAGE5 0.42 6.9 0.36 2.65e-11 Liver disease severity in Alagille syndrome; CRC cis rs10193935 0.901 rs6720837 chr2:42463173 A/T cg27598129 chr2:42591480 NA -0.47 -5.73 -0.3 2.31e-8 Colonoscopy-negative controls vs population controls; CRC cis rs7264396 0.778 rs6120959 chr20:34077848 G/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.39 -6.53 -0.34 2.44e-10 Total cholesterol levels; CRC cis rs3749237 0.595 rs6784820 chr3:49450864 C/T cg02487422 chr3:49467188 NICN1 -0.43 -6.92 -0.36 2.36e-11 Resting heart rate; CRC cis rs651907 0.535 rs11919389 chr3:101424458 T/C cg12386194 chr3:101231763 SENP7 0.49 7.02 0.36 1.28e-11 Colorectal cancer; CRC cis rs832540 0.669 rs832539 chr5:56199386 A/C cg03609598 chr5:56110824 MAP3K1 -0.57 -7.74 -0.39 1.27e-13 Coronary artery disease; CRC cis rs2070488 0.775 rs2268762 chr3:38516075 A/G cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.82 14.15 0.62 7.6e-36 Electrocardiographic conduction measures; CRC cis rs17270561 0.636 rs7775354 chr6:25745266 T/A cg16482183 chr6:26056742 HIST1H1C 0.83 10.69 0.51 4.46e-23 Iron status biomarkers; CRC cis rs4713118 0.662 rs4713120 chr6:27721835 C/A cg21251018 chr6:28226885 NKAPL 0.44 7.06 0.36 1e-11 Parkinson's disease; CRC cis rs28386778 0.897 rs7207005 chr17:61860355 A/G cg22520471 chr17:61851767 DDX42;CCDC47 0.75 11.69 0.54 1.26e-26 Prudent dietary pattern; CRC cis rs6754311 0.773 rs309176 chr2:136622216 T/C cg15123519 chr2:136567270 LCT 0.34 6.57 0.34 1.94e-10 Mosquito bite size; CRC cis rs10227331 0.934 rs2302447 chr7:157295985 A/T cg06076350 chr7:157294107 NA 0.35 6.44 0.33 4.3e-10 Inattentive symptoms; CRC trans rs11165623 0.564 rs6593612 chr1:97002041 C/A cg10631902 chr5:14652156 NA -0.39 -6.62 -0.34 1.42e-10 Hip circumference;Waist circumference; CRC cis rs10450586 0.863 rs10835150 chr11:27301061 C/G cg10370305 chr11:27303972 NA -0.38 -6.11 -0.32 2.83e-9 Total body bone mineral density; CRC cis rs6545883 0.507 rs2123111 chr2:61450454 A/G cg10580144 chr2:61372316 C2orf74 -0.35 -7.86 -0.4 5.56e-14 Tuberculosis; CRC cis rs45430 1.000 rs408825 chr21:42743496 A/G cg06102954 chr21:42741788 MX2 -0.39 -6.06 -0.32 3.81e-9 Melanoma; CRC cis rs2075371 1.000 rs378358 chr7:133970628 A/G cg02659138 chr7:134003124 SLC35B4 0.36 6.31 0.33 9.12e-10 Mean platelet volume; CRC cis rs853679 0.517 rs4713141 chr6:28101678 G/C cg03623178 chr6:28175578 NA 0.96 12.57 0.57 7.23e-30 Depression; CRC cis rs6582630 0.555 rs1829583 chr12:38423161 T/C cg26384229 chr12:38710491 ALG10B -0.65 -9.66 -0.47 1.36e-19 Drug-induced liver injury (flucloxacillin); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg00305188 chr1:205649794 SLC45A3 0.4 6.09 0.32 3.21e-9 Liver disease severity in Alagille syndrome; CRC cis rs7726839 0.540 rs11739847 chr5:609661 G/A cg16447950 chr5:562315 NA -0.74 -9.73 -0.47 7.89e-20 Obesity-related traits; CRC cis rs9527 0.571 rs4917985 chr10:104624072 C/T cg15744005 chr10:104629667 AS3MT -0.37 -7.45 -0.38 8.13e-13 Arsenic metabolism; CRC cis rs13343954 0.518 rs2216594 chr19:33533258 G/A cg27124370 chr19:33622961 WDR88 0.46 6.87 0.35 3.17e-11 Colorectal cancer; CRC cis rs12155623 0.619 rs17641604 chr8:49842784 C/T cg00325661 chr8:49890786 NA 0.39 6.79 0.35 5.22e-11 Sudden cardiac arrest; CRC cis rs6598955 1.000 rs10902728 chr1:26598281 T/C cg04990556 chr1:26633338 UBXN11 0.81 12.03 0.55 7.25e-28 Obesity-related traits; CRC cis rs8064299 1.000 rs8064299 chr17:72762646 C/A cg25054828 chr17:72772726 NAT9;TMEM104 0.61 9.43 0.46 7.82e-19 Monocyte count; CRC cis rs875971 0.830 rs7799834 chr7:65880694 A/C cg00343986 chr7:65444356 GUSB 0.43 6.3 0.33 9.66e-10 Aortic root size; CRC cis rs10193935 1.000 rs10180528 chr2:42436723 T/A cg27598129 chr2:42591480 NA -0.69 -7.86 -0.4 5.64e-14 Colonoscopy-negative controls vs population controls; CRC trans rs2303319 0.504 rs62188153 chr2:162313036 G/T cg19471553 chr17:41393123 NA -0.7 -6.07 -0.32 3.48e-9 Cognitive function; CRC cis rs8005677 1.000 rs10148215 chr14:23382345 C/T cg25600027 chr14:23388339 RBM23 -0.53 -8.33 -0.42 2.26e-15 Cognitive ability (multi-trait analysis); CRC cis rs758324 0.812 rs7709934 chr5:131145210 C/T cg25547332 chr5:131281432 NA 0.35 5.61 0.3 4.31e-8 Alzheimer's disease in APOE e4- carriers; CRC cis rs864537 0.618 rs2995089 chr1:167431193 G/A cg22356347 chr1:167427500 CD247 -0.4 -5.93 -0.31 7.7e-9 Celiac disease or Rheumatoid arthritis;Celiac disease; CRC cis rs11690935 0.959 rs6754817 chr2:172663394 C/T cg13550731 chr2:172543902 DYNC1I2 -1.05 -16.83 -0.68 2.85e-46 Schizophrenia; CRC cis rs7666738 0.830 rs11097605 chr4:98985167 T/C cg05340658 chr4:99064831 C4orf37 0.58 8.82 0.44 6.61e-17 Colonoscopy-negative controls vs population controls; CRC cis rs9311676 0.656 rs56097407 chr3:58378079 G/A cg06643156 chr3:58380774 PXK 0.41 6.33 0.33 7.82e-10 Systemic lupus erythematosus; CRC cis rs11122272 0.705 rs2572260 chr1:231486189 T/C cg06096015 chr1:231504339 EGLN1 0.39 5.9 0.31 8.9e-9 Hemoglobin concentration; CRC cis rs6951245 0.935 rs78573577 chr7:1089087 C/A cg18402987 chr7:1209562 NA 0.64 6.67 0.35 1.05e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC trans rs7873102 0.702 rs7028020 chr9:38007747 C/T cg06361278 chr17:25783929 NA -0.4 -5.97 -0.31 6.27e-9 Brain structure; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg25667490 chr4:72052924 SLC4A4 0.42 7.32 0.37 1.96e-12 Liver disease severity in Alagille syndrome; CRC cis rs10924970 0.967 rs4481838 chr1:235442626 A/G cg26050004 chr1:235667680 B3GALNT2 0.4 6.01 0.31 4.84e-9 Asthma; CRC cis rs4713118 0.513 rs149941 chr6:28001033 T/C cg12273811 chr6:28175739 NA 0.57 8.38 0.42 1.59e-15 Parkinson's disease; CRC cis rs13118159 0.509 rs1882098 chr4:1352431 T/C cg05025164 chr4:1340916 KIAA1530 0.6 8.54 0.43 5.12e-16 Longevity; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg17533455 chr5:130599827 CDC42SE2 0.35 6.02 0.31 4.76e-9 Liver disease severity in Alagille syndrome; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg03227456 chr1:8878193 RERE 0.46 6.33 0.33 8.16e-10 Response to antipsychotic treatment; CRC cis rs3087591 0.960 rs12945157 chr17:29603631 G/A cg24425628 chr17:29625626 OMG;NF1 0.88 16.87 0.68 1.83e-46 Hip circumference; CRC cis rs9911578 0.935 rs304261 chr17:56813782 A/G cg12560992 chr17:57184187 TRIM37 0.9 16.42 0.67 1.13e-44 Intelligence (multi-trait analysis); CRC cis rs3858526 0.883 rs7481882 chr11:5944221 A/G cg13902645 chr11:5959945 NA -0.61 -8.3 -0.42 2.67e-15 DNA methylation (variation); CRC cis rs7781557 0.640 rs17135916 chr7:102552997 A/C cg18108683 chr7:102477205 FBXL13 -0.48 -5.67 -0.3 3.21e-8 Colorectal adenoma (advanced); CRC cis rs5753618 0.509 rs5997913 chr22:31593959 C/A cg07713946 chr22:31675144 LIMK2 -0.39 -5.62 -0.3 4e-8 Colorectal cancer; CRC cis rs4666002 0.956 rs10179872 chr2:27778572 G/A cg27432699 chr2:27873401 GPN1 0.45 5.87 0.31 1.05e-8 Phospholipid levels (plasma); CRC cis rs4731207 0.596 rs12112909 chr7:124584834 C/T cg23710748 chr7:124431027 NA -0.39 -6.14 -0.32 2.34e-9 Cutaneous malignant melanoma; CRC trans rs8123881 0.733 rs7268466 chr20:15810676 C/T cg07919197 chr1:32646027 TXLNA 0.59 6.47 0.34 3.51e-10 Body mass index; CRC cis rs9311474 0.502 rs4687624 chr3:52563572 C/T cg05573699 chr3:52720067 GNL3;PBRM1 -0.39 -5.61 -0.3 4.2e-8 Electroencephalogram traits; CRC cis rs12762955 0.528 rs10903358 chr10:1102386 G/A cg20503657 chr10:835505 NA 0.83 9.73 0.47 8.14e-20 Response to angiotensin II receptor blocker therapy; CRC cis rs8072100 0.967 rs4239162 chr17:45755810 G/A cg08085267 chr17:45401833 C17orf57 -0.61 -9.68 -0.47 1.18e-19 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs2204008 0.774 rs11616004 chr12:38278822 G/A cg26384229 chr12:38710491 ALG10B 0.69 9.22 0.45 3.69e-18 Bladder cancer; CRC trans rs11088226 0.846 rs2833884 chr21:33923075 A/G cg09050820 chr6:167586206 TCP10L2 0.67 8.53 0.43 5.47e-16 Gastritis; CRC trans rs1814175 0.935 rs7482690 chr11:49648814 C/T cg11707556 chr5:10655725 ANKRD33B -0.41 -7.61 -0.39 2.9e-13 Height; CRC cis rs10849893 0.538 rs10744762 chr12:121839701 A/C cg01154721 chr12:121881891 KDM2B 0.44 6.69 0.35 9.59e-11 Fasting blood glucose;Fasting blood glucose (BMI interaction); CRC cis rs172166 0.516 rs2021826 chr6:28132756 G/A cg12172441 chr6:28176163 NA 0.45 6.55 0.34 2.25e-10 Cardiac Troponin-T levels; CRC cis rs7772486 0.790 rs9497431 chr6:146248177 T/C cg23711669 chr6:146136114 FBXO30 -0.74 -12.95 -0.58 2.8e-31 Lobe attachment (rater-scored or self-reported); CRC cis rs11958404 0.929 rs60700182 chr5:157438376 A/G cg05962755 chr5:157440814 NA 0.95 12.34 0.56 5.17e-29 IgG glycosylation; CRC cis rs739401 0.527 rs418832 chr11:3072236 C/T cg08508325 chr11:3079039 CARS -0.51 -9.28 -0.46 2.35e-18 Longevity; CRC cis rs12188164 0.965 rs72717430 chr5:444502 T/C cg21972741 chr5:435613 AHRR 0.54 7.37 0.38 1.39e-12 Cystic fibrosis severity; CRC cis rs4319547 0.615 rs2341439 chr12:122848096 C/G cg05707623 chr12:122985044 ZCCHC8 -0.63 -7.91 -0.4 4.05e-14 Body mass index; CRC cis rs561341 1.000 rs72823789 chr17:30284084 G/A cg12193833 chr17:30244370 NA -0.75 -8.72 -0.43 1.4e-16 Hip circumference adjusted for BMI; CRC cis rs6952808 0.578 rs6949478 chr7:1841342 A/G cg22963979 chr7:1858916 MAD1L1 0.74 11.37 0.53 1.77e-25 Bipolar disorder and schizophrenia; CRC trans rs2727020 0.538 rs11040373 chr11:49461791 T/C cg21153622 chr11:89784906 NA -0.44 -7.33 -0.37 1.84e-12 Coronary artery disease; CRC cis rs72781680 0.898 rs6712524 chr2:24083925 T/C cg08917208 chr2:24149416 ATAD2B 0.92 9.38 0.46 1.15e-18 Lymphocyte counts; CRC cis rs2836974 0.666 rs4818015 chr21:40675493 A/C cg06238570 chr21:40685208 BRWD1 0.81 13.08 0.59 8.74e-32 Cognitive function; CRC cis rs875971 0.862 rs709596 chr7:65825913 A/G cg11764359 chr7:65958608 NA 0.59 9.34 0.46 1.55e-18 Aortic root size; CRC trans rs3942852 0.806 rs11039515 chr11:48119474 A/G cg03929089 chr4:120376271 NA 0.56 7.25 0.37 2.95e-12 Acute lymphoblastic leukemia (childhood); CRC cis rs7666738 0.791 rs13149968 chr4:99070262 G/T cg05340658 chr4:99064831 C4orf37 0.6 9.32 0.46 1.72e-18 Colonoscopy-negative controls vs population controls; CRC cis rs644799 0.672 rs11021347 chr11:95653494 T/C cg25622487 chr11:95524042 FAM76B;CEP57 0.73 11.46 0.53 8.01e-26 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs853679 0.666 rs200956 chr6:27839746 A/G cg06470822 chr6:28175283 NA 0.71 8.4 0.42 1.39e-15 Depression; CRC cis rs274567 0.501 rs272856 chr5:131687081 G/C cg24060327 chr5:131705240 SLC22A5 -0.49 -7.02 -0.36 1.29e-11 Blood metabolite levels; CRC cis rs7635838 0.653 rs2606749 chr3:11373635 A/G cg00170343 chr3:11313890 ATG7 0.47 7.13 0.37 6.49e-12 HDL cholesterol; CRC cis rs668210 0.793 rs1204011 chr11:65741086 G/A cg02202077 chr11:65769826 EIF1AD;BANF1 -0.52 -6.35 -0.33 7.3e-10 Cerebrospinal fluid biomarker levels; CRC cis rs8072100 0.875 rs4794047 chr17:45763005 A/T cg08085267 chr17:45401833 C17orf57 0.62 9.94 0.48 1.56e-20 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC trans rs10838798 0.504 rs7121133 chr11:48156131 G/A cg21153622 chr11:89784906 NA -0.43 -6.75 -0.35 6.5500000000000006e-11 Height; CRC cis rs11212617 0.934 rs172896 chr11:108217049 T/G cg12106634 chr11:108092400 ATM;NPAT 0.43 6.34 0.33 7.46e-10 Response to metformin in type 2 diabetes (glycemic); CRC cis rs9926296 0.572 rs8047581 chr16:89884502 C/T cg04287289 chr16:89883240 FANCA 0.64 10.68 0.51 4.51e-23 Vitiligo; CRC cis rs4561483 0.801 rs33643 chr16:11986149 A/G cg08843971 chr16:11963173 GSPT1 -0.64 -9.9 -0.48 2.14e-20 Testicular germ cell tumor; CRC cis rs11792861 0.926 rs7046725 chr9:111882729 T/G cg05043794 chr9:111880884 C9orf5 -0.33 -6.02 -0.32 4.59e-9 Menarche (age at onset); CRC cis rs881375 0.933 rs7031096 chr9:123694942 T/C cg09419670 chr9:123605666 PSMD5;LOC253039 0.57 8.45 0.42 9.68e-16 Rheumatoid arthritis; CRC cis rs7113874 0.524 rs9704586 chr11:8578530 T/G cg02811074 chr11:8615871 STK33 -0.34 -5.87 -0.31 1.05e-8 Body mass index in physically active individuals;Body mass index (joint analysis main effects and physical activity interaction); CRC trans rs561341 0.769 rs7217004 chr17:30178092 A/G cg00801512 chr17:28996047 NA 0.53 6.04 0.32 4.22e-9 Hip circumference adjusted for BMI; CRC cis rs1577917 0.538 rs7755996 chr6:86423720 C/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A 0.6 8.62 0.43 2.94e-16 Response to antipsychotic treatment; CRC cis rs1816752 0.870 rs7998797 chr13:25014988 A/C cg02811702 chr13:24901961 NA 0.47 6.55 0.34 2.16e-10 Obesity-related traits; CRC cis rs847649 0.692 rs10271184 chr7:102477176 A/G cg18108683 chr7:102477205 FBXL13 -0.67 -11.28 -0.53 3.62e-25 Morning vs. evening chronotype; CRC cis rs6748734 1.000 rs3936203 chr2:241834654 C/T cg07537917 chr2:241836409 C2orf54 0.21 5.95 0.31 6.84e-9 Urinary metabolites; CRC cis rs35306767 0.715 rs11253550 chr10:1028288 C/G cg20503657 chr10:835505 NA 0.94 10.72 0.51 3.35e-23 Eosinophil percentage of granulocytes; CRC cis rs1348850 0.914 rs4341974 chr2:178324879 A/C cg02961200 chr2:178257176 LOC100130691;AGPS 0.58 8.41 0.42 1.27e-15 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs4363385 0.818 rs451939 chr1:153006877 C/T cg25856811 chr1:152973957 SPRR3 -0.25 -6.99 -0.36 1.51e-11 Inflammatory skin disease; CRC cis rs1577917 0.958 rs36053156 chr6:86575509 T/A cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.59 -7.29 -0.37 2.26e-12 Response to antipsychotic treatment; CRC cis rs79839061 0.562 rs62294484 chr4:935571 A/G cg07828340 chr4:882639 GAK 1.12 10.94 0.52 5.82e-24 Intelligence (multi-trait analysis); CRC cis rs13064411 0.696 rs1552432 chr3:113225660 G/C cg18753928 chr3:113234510 CCDC52 -0.7 -10.74 -0.51 2.89e-23 Response to simvastatin treatment (PCSK9 protein level change); CRC cis rs897984 0.762 rs2305880 chr16:30999462 T/C cg02466173 chr16:30829666 NA 0.63 9.58 0.47 2.42e-19 Dementia with Lewy bodies; CRC cis rs67311347 1.000 rs34762643 chr3:40475433 C/T cg24209194 chr3:40518798 ZNF619 0.42 6.33 0.33 8.25e-10 Renal cell carcinoma; CRC cis rs10493773 0.532 rs1889919 chr1:86180034 A/G cg23216685 chr1:86174607 ZNHIT6 -0.27 -6.61 -0.34 1.57e-10 Urate levels in overweight individuals; CRC trans rs2243480 1.000 rs160648 chr7:65543384 C/A cg10756647 chr7:56101905 PSPH 0.62 6.58 0.34 1.8e-10 Diabetic kidney disease; CRC cis rs12024301 0.557 rs6699033 chr1:183622450 T/A cg11505048 chr1:183622726 RGL1;APOBEC4 0.81 6.99 0.36 1.53e-11 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs62244186 0.715 rs13321717 chr3:44667455 C/A cg11003573 chr3:44754125 ZNF502 -0.37 -6.29 -0.33 1.03e-9 Depressive symptoms; CRC cis rs4865169 0.560 rs1277311 chr4:57902761 C/T cg25525207 chr4:57843836 C4orf14;POLR2B -0.4 -5.63 -0.3 3.89e-8 Breast cancer; CRC cis rs2243480 1.000 rs34637256 chr7:65360131 G/A cg12463550 chr7:65579703 CRCP 0.66 6.14 0.32 2.36e-9 Diabetic kidney disease; CRC cis rs10911363 0.592 rs2782411 chr1:183476929 G/A cg09173681 chr1:183549694 NCF2 0.74 10.1 0.49 4.64e-21 Systemic lupus erythematosus; CRC cis rs4466137 1.000 rs1154888 chr5:82977410 C/A cg16102102 chr5:83017553 HAPLN1 -0.54 -7.63 -0.39 2.52e-13 Prostate cancer; CRC cis rs68149176 0.772 rs997762 chr16:87879562 C/A cg03553613 chr16:87879502 SLC7A5 -0.56 -7.47 -0.38 7.46e-13 Mean corpuscular volume;Mean corpuscular hemoglobin; CRC cis rs8141529 0.764 rs8137969 chr22:29228484 G/C cg02153584 chr22:29168773 CCDC117 0.52 7.76 0.39 1.07e-13 Lymphocyte counts; CRC cis rs6684514 1.000 rs10908494 chr1:156263097 A/G cg16558208 chr1:156270281 VHLL 0.58 9.09 0.45 9.51e-18 Mean corpuscular hemoglobin concentration;Glycated hemoglobin levels; CRC cis rs4478858 0.839 rs10798834 chr1:31708977 G/A cg00250761 chr1:31883323 NA -0.43 -8.49 -0.42 7.07e-16 Alcohol dependence; CRC cis rs3087591 0.683 rs2525567 chr17:29675673 C/A cg24425628 chr17:29625626 OMG;NF1 0.71 13.19 0.59 3.46e-32 Hip circumference; CRC cis rs9925964 0.687 rs12917722 chr16:30948397 A/G cg02466173 chr16:30829666 NA 0.45 6.13 0.32 2.51e-9 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC trans rs1814175 0.791 rs1722023 chr11:49908136 G/C cg11707556 chr5:10655725 ANKRD33B -0.44 -8.31 -0.42 2.52e-15 Height; CRC cis rs1143633 0.579 rs3811042 chr2:113670834 G/A cg06771106 chr2:113671356 IL1F7 0.43 6.16 0.32 2.14e-9 Allergic disease (asthma, hay fever or eczema); CRC cis rs524023 0.958 rs3825016 chr11:64359286 C/T cg14139581 chr11:64358342 SLC22A12 -0.39 -6.19 -0.32 1.81e-9 Urate levels in obese individuals; CRC cis rs17209837 0.527 rs45479991 chr7:87083339 A/T cg00919237 chr7:87102261 ABCB4 -0.54 -7.15 -0.37 5.78e-12 Gallbladder cancer; CRC cis rs55665837 1.000 rs7121171 chr11:14446420 A/G cg19336497 chr11:14380999 RRAS2 -0.4 -6.85 -0.35 3.65e-11 Vitamin D levels; CRC cis rs9487051 0.676 rs7773775 chr6:109600339 T/C cg12927641 chr6:109611667 NA -0.36 -6.32 -0.33 8.39e-10 Reticulocyte fraction of red cells; CRC trans rs2303319 0.504 rs62189055 chr2:162625749 C/A cg26358599 chr1:24018029 RPL11 -0.74 -6.02 -0.31 4.71e-9 Cognitive function; CRC cis rs4474465 0.688 rs4945300 chr11:78282632 T/C cg27205649 chr11:78285834 NARS2 0.54 7.1 0.36 7.85e-12 Alzheimer's disease (survival time); CRC cis rs1552244 0.882 rs68153882 chr3:10013110 T/C cg18598329 chr3:10140678 FANCD2;C3orf24 -0.82 -10.77 -0.51 2.31e-23 Alzheimer's disease; CRC cis rs875971 0.638 rs10249404 chr7:66046724 G/A cg11764359 chr7:65958608 NA -0.55 -8.65 -0.43 2.36e-16 Aortic root size; CRC cis rs116095464 0.558 rs56127718 chr5:270273 G/T cg22496380 chr5:211416 CCDC127 -0.91 -10.56 -0.5 1.22e-22 Breast cancer; CRC trans rs1005277 0.579 rs2472174 chr10:38375382 A/G cg11292332 chr7:45801988 SEPT13 -0.35 -6.21 -0.32 1.61e-9 Extrinsic epigenetic age acceleration; CRC cis rs34779708 0.931 rs4934700 chr10:35310842 A/G cg03585969 chr10:35415529 CREM 0.67 8.88 0.44 4.41e-17 Inflammatory bowel disease;Crohn's disease; CRC cis rs7811142 0.830 rs6948685 chr7:99970188 C/T cg00814883 chr7:100076585 TSC22D4 -0.71 -8.76 -0.44 1.02e-16 Platelet count; CRC cis rs780096 0.527 rs59644396 chr2:27646083 A/G cg24768116 chr2:27665128 KRTCAP3 -0.36 -8.28 -0.42 3.09e-15 Total body bone mineral density; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg23653712 chr4:52904379 SGCB 0.46 7.69 0.39 1.69e-13 Liver disease severity in Alagille syndrome; CRC trans rs7824557 0.564 rs2043508 chr8:11227406 G/A cg07998479 chr3:129830310 LOC729375 0.4 5.99 0.31 5.37e-9 Retinal vascular caliber; CRC cis rs1799949 1.000 rs4340367 chr17:41307772 G/A cg19454999 chr17:41278357 BRCA1;NBR2 0.55 8.66 0.43 2.2e-16 Menopause (age at onset); CRC cis rs6860806 0.507 rs272880 chr5:131670178 C/T cg12564285 chr5:131593104 PDLIM4 0.45 7.53 0.38 5.05e-13 Breast cancer; CRC trans rs9956878 0.555 rs8085188 chr18:73544676 A/G cg06384952 chr3:183602746 PARL -0.4 -6.23 -0.32 1.39e-9 Obesity-related traits; CRC cis rs875971 0.862 rs1612452 chr7:65573896 T/A cg12463550 chr7:65579703 CRCP -0.53 -7.53 -0.38 4.84e-13 Aortic root size; CRC cis rs11123170 0.543 rs4849178 chr2:113982608 C/T cg11763394 chr2:113992921 PAX8;LOC440839;LOC654433 0.51 5.93 0.31 7.71e-9 Renal function-related traits (BUN); CRC cis rs4665809 1.000 rs12475854 chr2:26267375 G/A cg26119090 chr2:26468346 HADHA;HADHB -0.61 -7.96 -0.4 2.87e-14 Gut microbiome composition (summer); CRC cis rs10256972 0.758 rs2280724 chr7:1064720 A/G cg04025307 chr7:1156635 C7orf50 0.49 7.28 0.37 2.52e-12 Longevity;Endometriosis; CRC cis rs344364 0.511 rs1742467 chr16:1950187 G/T cg03013636 chr16:1946785 NA 0.58 7.08 0.36 8.69e-12 Glomerular filtration rate in chronic kidney disease; CRC cis rs11166927 0.524 rs2035087 chr8:140831320 A/G cg16909799 chr8:140841666 TRAPPC9 -0.42 -6.24 -0.33 1.32e-9 Pediatric non-alcoholic fatty liver disease activity score; CRC cis rs4713118 0.662 rs149946 chr6:27970031 A/C cg21251018 chr6:28226885 NKAPL -0.44 -6.44 -0.33 4.2e-10 Parkinson's disease; CRC cis rs4862750 0.872 rs13101408 chr4:187894777 G/A cg06074448 chr4:187884817 NA -0.6 -11.22 -0.53 5.92e-25 Lobe attachment (rater-scored or self-reported); CRC cis rs10992471 1.000 rs10992471 chr9:95559505 A/G cg13798575 chr9:95087839 CENPP;NOL8 0.45 6.62 0.34 1.42e-10 Visceral adipose tissue/subcutaneous adipose tissue ratio; CRC cis rs417013 0.668 rs201519 chr7:101770505 G/A cg06246474 chr7:101738831 CUX1 0.37 5.66 0.3 3.27e-8 Lobe attachment (rater-scored or self-reported); CRC cis rs704795 0.867 rs7566052 chr2:27628635 A/G cg27432699 chr2:27873401 GPN1 -0.51 -7.71 -0.39 1.49e-13 Menopause (age at onset); CRC cis rs2070488 0.931 rs6599212 chr3:38558906 T/C cg01465620 chr3:38496096 LOC100128640;ACVR2B -0.87 -16.16 -0.67 1.19e-43 Electrocardiographic conduction measures; CRC cis rs9858542 0.903 rs11917431 chr3:49644012 C/T cg03060546 chr3:49711283 APEH -0.51 -6.86 -0.35 3.48e-11 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs921968 0.541 rs3770213 chr2:219508372 A/T cg02176678 chr2:219576539 TTLL4 -0.61 -9.55 -0.47 3e-19 Mean corpuscular hemoglobin concentration; CRC cis rs11148252 0.624 rs6561682 chr13:53266297 A/G cg00495681 chr13:53174319 NA -0.56 -7.88 -0.4 4.95e-14 Lewy body disease; CRC cis rs9894429 0.646 rs12603868 chr17:79618834 G/C cg21984481 chr17:79567631 NPLOC4 -0.42 -7.07 -0.36 9.14e-12 Eye color traits; CRC cis rs853679 0.517 rs9468297 chr6:28118874 G/T cg12172441 chr6:28176163 NA 0.64 7.53 0.38 5.03e-13 Depression; CRC cis rs2122752 0.527 rs10187244 chr2:98816010 A/T cg17915676 chr2:98928898 VWA3B -0.32 -5.66 -0.3 3.24e-8 Gestational age at birth in premature rupture of membrane-initiated deliveries (maternal effect); CRC cis rs2032447 0.832 rs6922788 chr6:26052291 C/T cg12588279 chr6:26043732 HIST1H2BB 0.42 6.08 0.32 3.41e-9 Intelligence (multi-trait analysis); CRC cis rs2179367 0.959 rs540538 chr6:149647944 C/T cg11245181 chr6:149772854 ZC3H12D -0.41 -6.15 -0.32 2.23e-9 Dupuytren's disease; CRC cis rs9814567 1.000 rs1534026 chr3:134284767 A/G cg06109529 chr3:134205091 CEP63;ANAPC13 -0.82 -12.36 -0.56 4.3e-29 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs9487051 0.933 rs5005289 chr6:109617673 C/G cg21918786 chr6:109611834 NA -0.38 -6.56 -0.34 2.09e-10 Reticulocyte fraction of red cells; CRC cis rs668210 0.947 rs559161 chr11:65761637 A/G cg02202077 chr11:65769826 EIF1AD;BANF1 0.45 6.38 0.33 5.97e-10 Cerebrospinal fluid biomarker levels; CRC cis rs2228479 0.850 rs2239358 chr16:89827330 C/G cg19635926 chr16:89946313 TCF25 0.63 5.68 0.3 3.01e-8 Skin colour saturation; CRC cis rs3106136 0.546 rs2632417 chr4:95137542 G/C cg11021082 chr4:95130006 SMARCAD1 -0.6 -9.47 -0.46 5.61e-19 Capecitabine sensitivity; CRC cis rs2046867 0.818 rs17690720 chr3:72866030 T/C cg25664220 chr3:72788482 NA -0.46 -6.65 -0.34 1.21e-10 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; CRC cis rs367943 1.000 rs191553 chr5:112823659 A/G cg12552261 chr5:112820674 MCC -0.49 -7.52 -0.38 5.23e-13 Type 2 diabetes; CRC cis rs7312933 1.000 rs7957213 chr12:42475438 T/G cg11827402 chr12:42719852 PPHLN1;ZCRB1 0.6 7.64 0.39 2.43e-13 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CRC cis rs172166 0.694 rs1150666 chr6:28123928 T/C cg12273811 chr6:28175739 NA 0.61 8.8 0.44 8.09e-17 Cardiac Troponin-T levels; CRC cis rs8062405 1.000 rs4788102 chr16:28873398 G/A cg16576597 chr16:28551801 NUPR1 0.48 6.82 0.35 4.39e-11 Cognitive ability (multi-trait analysis);Cognitive ability; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg03711348 chr7:22862508 TOMM7 0.38 6.13 0.32 2.44e-9 Liver disease severity in Alagille syndrome; CRC cis rs1538970 0.962 rs7544178 chr1:45819069 C/T cg05343316 chr1:45956843 TESK2 0.69 9.26 0.45 2.7e-18 Platelet count; CRC cis rs6011002 0.550 rs6010634 chr20:62363838 T/C cg01176363 chr20:62369445 LIME1 -0.72 -5.67 -0.3 3.14e-8 Dental caries; CRC trans rs61931739 0.534 rs10844828 chr12:34303109 C/T cg26384229 chr12:38710491 ALG10B 0.46 6.6 0.34 1.62e-10 Morning vs. evening chronotype; CRC trans rs7615952 0.599 rs12486459 chr3:125741465 T/G cg07211511 chr3:129823064 LOC729375 -0.77 -10.24 -0.49 1.47e-21 Blood pressure (smoking interaction); CRC cis rs2976388 1.000 rs2920294 chr8:143765326 C/G cg22687807 chr8:143858763 LYNX1 -0.38 -6.67 -0.35 1.1e-10 Urinary tract infection frequency; CRC cis rs7580658 0.857 rs11890187 chr2:128083738 T/C cg09760422 chr2:128146352 NA -0.3 -5.8 -0.3 1.58e-8 Protein C levels; CRC cis rs9640161 0.830 rs17173682 chr7:150059602 A/G cg13722127 chr7:150037890 RARRES2 0.39 5.69 0.3 2.86e-8 Blood protein levels;Circulating chemerin levels; CRC cis rs7493 1.000 rs2158806 chr7:95051998 A/C cg21856205 chr7:94953877 PON1 -0.5 -6.49 -0.34 3.25e-10 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs9309711 0.666 rs6723101 chr2:3484443 T/C cg15506890 chr2:3487001 NA -0.53 -8.61 -0.43 3.09e-16 Neurofibrillary tangles; CRC cis rs875971 0.545 rs1638735 chr7:66095738 C/T cg05627663 chr7:65219948 SNORA22;CCT6P1 0.6 7.54 0.38 4.77e-13 Aortic root size; CRC cis rs1552244 0.882 rs67895180 chr3:10026079 T/C cg18598329 chr3:10140678 FANCD2;C3orf24 -0.81 -10.69 -0.51 4.18e-23 Alzheimer's disease; CRC cis rs10504229 0.638 rs7826839 chr8:58132075 G/T cg05313129 chr8:58192883 C8orf71 -0.43 -6.11 -0.32 2.74e-9 Developmental language disorder (linguistic errors); CRC cis rs7772486 0.658 rs4895683 chr6:146113654 T/A cg13319975 chr6:146136371 FBXO30 0.46 6.91 0.36 2.53e-11 Lobe attachment (rater-scored or self-reported); CRC cis rs4481887 0.741 rs6587458 chr1:248532290 T/A cg26353448 chr1:248524236 OR2T4 -0.35 -6.68 -0.35 1.02e-10 Common traits (Other); CRC cis rs11148252 0.538 rs3368 chr13:52707240 C/G cg02158880 chr13:53174818 NA 0.4 5.63 0.3 3.91e-8 Lewy body disease; CRC cis rs1707322 0.655 rs3014240 chr1:46089225 C/G cg06784218 chr1:46089804 CCDC17 -0.66 -12.02 -0.55 7.8e-28 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs875971 0.545 rs1796219 chr7:66110964 A/G cg18876405 chr7:65276391 NA -0.48 -6.51 -0.34 2.88e-10 Aortic root size; CRC cis rs4728302 0.934 rs10258052 chr7:133635874 T/C cg10665199 chr7:133106180 EXOC4 -0.39 -6.14 -0.32 2.34e-9 Intelligence;Intelligence (multi-trait analysis); CRC cis rs9322193 0.887 rs9767113 chr6:150039293 T/C cg13206674 chr6:150067644 NUP43 0.64 9.0 0.44 1.83e-17 Lung cancer; CRC cis rs747650 0.961 rs7945315 chr11:47110652 A/C cg03339077 chr11:47165057 C11orf49 0.45 6.31 0.33 8.83e-10 Acne (severe); CRC trans rs6472235 0.837 rs2357569 chr8:66917137 A/G cg07884673 chr3:53033167 SFMBT1 -0.45 -6.12 -0.32 2.62e-9 Myopia (pathological);Plateletcrit; CRC cis rs1552244 0.572 rs2054478 chr3:10172211 C/T cg16606324 chr3:10149918 C3orf24 0.69 8.08 0.41 1.2e-14 Alzheimer's disease; CRC cis rs1348850 0.526 rs2178017 chr2:178374788 G/T cg27490568 chr2:178487706 NA 0.62 7.52 0.38 5.43e-13 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs2462686 0.930 rs2462687 chr7:45982306 C/T cg23193639 chr7:45961078 IGFBP3 -0.39 -6.16 -0.32 2.14e-9 Major depressive disorder; CRC cis rs875971 0.628 rs6974355 chr7:65841981 A/G cg11764359 chr7:65958608 NA 0.55 8.29 0.42 2.97e-15 Aortic root size; CRC cis rs13108904 0.901 rs13119532 chr4:1304505 G/C cg20092199 chr4:1342459 KIAA1530 0.35 5.91 0.31 8.62e-9 Obesity-related traits; CRC cis rs71403859 0.502 rs34766979 chr16:71475511 G/A cg08717414 chr16:71523259 ZNF19 -0.98 -9.67 -0.47 1.26e-19 Post bronchodilator FEV1; CRC cis rs11098499 0.619 rs28502463 chr4:120257023 T/C cg09307838 chr4:120376055 NA 0.62 9.59 0.47 2.22e-19 Corneal astigmatism; CRC cis rs55823223 0.503 rs55699990 chr17:73859186 A/G cg24416660 chr17:73865998 NA -0.4 -6.08 -0.32 3.34e-9 Psoriasis; CRC cis rs9906695 0.898 rs113274498 chr17:32566488 T/C cg12698626 chr17:32581466 CCL2 0.42 5.8 0.3 1.57e-8 Monocyte percentage of white cells; CRC cis rs6500602 0.653 rs3747579 chr16:4445327 A/G cg14951292 chr16:4525986 HMOX2;NMRAL1 -0.41 -5.73 -0.3 2.25e-8 Schizophrenia; CRC cis rs908922 0.636 rs474086 chr1:152513431 C/T cg23254163 chr1:152506842 NA 0.45 8.8 0.44 8e-17 Hair morphology; CRC cis rs709400 0.633 rs10141433 chr14:103962559 A/G cg12935359 chr14:103987150 CKB -0.51 -8.27 -0.41 3.46e-15 Body mass index; CRC trans rs9388451 0.805 rs1028481 chr6:126106573 G/T cg05039488 chr6:79577232 IRAK1BP1 -0.55 -8.28 -0.42 3.05e-15 Brugada syndrome; CRC cis rs9322193 0.884 rs880245 chr6:150167398 A/G cg07701084 chr6:150067640 NUP43 -0.55 -7.53 -0.38 4.87e-13 Lung cancer; CRC cis rs11123170 0.650 rs2289897 chr2:113977454 G/A cg19083407 chr2:113993142 PAX8;LOC440839;LOC654433 0.55 6.53 0.34 2.44e-10 Renal function-related traits (BUN); CRC cis rs1448094 0.527 rs59445394 chr12:86237843 C/T cg02569458 chr12:86230093 RASSF9 0.46 7.7 0.39 1.62e-13 Major depressive disorder; CRC trans rs7395662 0.571 rs4881998 chr11:48525186 C/T cg21153622 chr11:89784906 NA -0.51 -8.52 -0.43 6.01e-16 HDL cholesterol; CRC cis rs8141529 0.748 rs132533 chr22:29299571 A/G cg02153584 chr22:29168773 CCDC117 -0.47 -6.72 -0.35 8.16e-11 Lymphocyte counts; CRC cis rs13082711 0.911 rs4973769 chr3:27425746 T/C cg02860705 chr3:27208620 NA 0.6 8.69 0.43 1.75e-16 Systolic blood pressure;Diastolic blood pressure;Blood pressure; CRC cis rs9733 0.536 rs6661415 chr1:150635869 G/A cg15448220 chr1:150897856 SETDB1 0.45 6.46 0.34 3.88e-10 Tonsillectomy; CRC cis rs6496667 1.000 rs1452408 chr15:90891117 A/C cg04176472 chr15:90893244 GABARAPL3 0.55 8.56 0.43 4.4e-16 Rheumatoid arthritis; CRC cis rs7731657 0.537 rs4705995 chr5:130350688 G/A cg08523029 chr5:130500466 HINT1 -0.45 -5.77 -0.3 1.85e-8 Fasting plasma glucose; CRC trans rs360798 0.532 rs2136737 chr2:62969310 G/C cg05376469 chr2:102649931 NA 0.39 6.38 0.33 6.05e-10 Coronary artery disease; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg21434440 chr6:47446198 CD2AP 0.48 6.83 0.35 4.09e-11 Response to antipsychotic treatment; CRC cis rs9926296 0.744 rs460984 chr16:89713174 C/T cg03605463 chr16:89740564 NA 0.59 8.92 0.44 3.42e-17 Vitiligo; CRC cis rs9308731 0.644 rs60286362 chr2:111877493 G/C cg18646521 chr2:111875858 NA 0.4 6.31 0.33 9.12e-10 Chronic lymphocytic leukemia; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg10309340 chr10:102747329 C10orf2;MRPL43 0.38 6.19 0.32 1.78e-9 Liver disease severity in Alagille syndrome; CRC cis rs4268898 0.931 rs7603997 chr2:24524958 C/T cg06627628 chr2:24431161 ITSN2 -0.56 -8.5 -0.42 6.87e-16 Asthma; CRC cis rs11864453 0.713 rs8051882 chr16:72142072 A/G cg23815491 chr16:72088622 HP -0.46 -6.94 -0.36 2.05e-11 Fibrinogen levels; CRC cis rs891088 0.695 rs28695870 chr19:7197988 C/T cg00428638 chr19:7224713 INSR -0.6 -7.55 -0.38 4.25e-13 Hip circumference adjusted for BMI;Height; CRC cis rs7412746 0.658 rs11582281 chr1:150826831 T/C cg10589385 chr1:150898437 SETDB1 0.34 6.83 0.35 4.03e-11 Melanoma; CRC cis rs4664293 0.667 rs2042782 chr2:160646292 G/A cg08347373 chr2:160653686 CD302 0.51 8.74 0.43 1.21e-16 Monocyte percentage of white cells; CRC cis rs317865 0.737 rs73234644 chr4:16190661 T/G cg04764131 chr4:16228633 TAPT1;FLJ39653 0.63 5.71 0.3 2.58e-8 Kidney disease (early stage) in type 1 diabetes; CRC cis rs17826219 0.568 rs2626985 chr17:29077437 A/G cg01831904 chr17:28903510 LRRC37B2 -0.63 -6.48 -0.34 3.29e-10 Body mass index; CRC cis rs7781266 0.790 rs6467492 chr7:133139713 C/T cg03336402 chr7:133662267 EXOC4 0.46 5.65 0.3 3.5e-8 Educational attainment (college completion); CRC cis rs735396 1.000 rs1169313 chr12:121442670 C/T cg02403541 chr12:121454288 C12orf43 -0.43 -6.53 -0.34 2.54e-10 N-glycan levels; CRC cis rs4499344 0.633 rs259246 chr19:33146154 G/C cg08127369 chr19:33164662 ANKRD27 0.39 5.95 0.31 6.82e-9 Mean platelet volume; CRC cis rs2976388 0.556 rs10956985 chr8:143818750 C/A cg12516270 chr8:143859308 LYNX1 -0.41 -6.38 -0.33 5.92e-10 Urinary tract infection frequency; CRC cis rs2070488 1.000 rs2070488 chr3:38442490 A/G cg01465620 chr3:38496096 LOC100128640;ACVR2B -0.86 -15.54 -0.65 3.08e-41 Electrocardiographic conduction measures; CRC cis rs1691799 0.867 rs961049 chr12:66762591 A/C cg16791601 chr12:66731901 HELB 0.64 9.83 0.48 3.73e-20 White blood cell count (basophil); CRC cis rs10878977 0.542 rs9645828 chr12:69814792 G/A cg20891283 chr12:69753455 YEATS4 -0.59 -5.77 -0.3 1.83e-8 Colorectal cancer; CRC cis rs6866344 0.697 rs6873150 chr5:178125704 G/A cg10224037 chr5:178157518 ZNF354A 0.74 11.06 0.52 2.2e-24 Neutrophil percentage of white cells; CRC cis rs7617480 0.648 rs9864243 chr3:48982732 G/A cg20833759 chr3:49053208 WDR6;DALRD3 0.73 11.48 0.53 7.14e-26 Subjective well-being (multi-trait analysis);Menarche (age at onset); CRC cis rs9323205 0.677 rs61987261 chr14:51723879 G/A cg23942311 chr14:51606299 NA -0.53 -6.24 -0.33 1.36e-9 Cancer; CRC cis rs62432291 0.681 rs423533 chr6:159664516 G/T cg14500486 chr6:159655392 FNDC1 -0.76 -10.03 -0.48 7.86e-21 Joint mobility (Beighton score); CRC cis rs8072100 0.934 rs6504872 chr17:45438952 C/T cg25173405 chr17:45401733 C17orf57 -0.54 -8.96 -0.44 2.55e-17 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs11098499 0.863 rs13149407 chr4:120437825 A/G cg24375607 chr4:120327624 NA 0.48 7.3 0.37 2.2e-12 Corneal astigmatism; CRC cis rs875971 0.545 rs10950029 chr7:65634321 A/C cg05627663 chr7:65219948 SNORA22;CCT6P1 0.59 7.78 0.39 9.16e-14 Aortic root size; CRC cis rs7259376 0.936 rs1865073 chr19:22554980 T/G cg02657401 chr19:22469223 NA -0.31 -6.77 -0.35 5.96e-11 Menopause (age at onset); CRC cis rs4332037 0.539 rs55988458 chr7:2059761 G/A cg23422044 chr7:1970798 MAD1L1 -0.55 -6.59 -0.34 1.79e-10 Bipolar disorder; CRC cis rs7586879 0.789 rs7560156 chr2:25124794 T/C cg22495460 chr2:25135724 ADCY3 -0.88 -14.99 -0.64 4.29e-39 Body mass index; CRC cis rs2836974 0.568 rs419469 chr21:40537234 C/T cg22974920 chr21:40686053 BRWD1 0.41 5.68 0.3 2.91e-8 Cognitive function; CRC cis rs9659323 1.000 rs6680737 chr1:119521631 G/A cg26570165 chr1:119541833 NA -0.39 -6.46 -0.34 3.76e-10 Body mass index; CRC cis rs860295 0.812 rs12407800 chr1:155760742 A/C cg02153340 chr1:155202674 NA -0.51 -6.27 -0.33 1.15e-9 Body mass index; CRC cis rs2013441 1.000 rs2703806 chr17:20108239 A/T cg13482628 chr17:19912719 NA -0.42 -6.57 -0.34 1.95e-10 Obesity-related traits; CRC cis rs12519773 0.502 rs67862943 chr5:92529268 G/A cg18783429 chr5:92414398 NA 0.26 5.65 0.3 3.54e-8 Migraine; CRC cis rs9467603 1.000 rs9461216 chr6:25808743 A/T cg16898833 chr6:26189333 HIST1H4D 0.8 6.56 0.34 2.08e-10 Intelligence (multi-trait analysis); CRC cis rs9463078 0.764 rs1576382 chr6:44957553 G/A cg25276700 chr6:44698697 NA -0.28 -6.88 -0.35 3.1e-11 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; CRC cis rs1992660 0.523 rs7707395 chr5:40343533 G/C cg09067459 chr5:40385259 NA 0.44 7.46 0.38 7.53e-13 Crohn's disease; CRC cis rs9322193 0.962 rs13215691 chr6:150113802 T/C cg07701084 chr6:150067640 NUP43 0.46 6.47 0.34 3.64e-10 Lung cancer; CRC cis rs4731207 0.698 rs4731217 chr7:124471889 T/C cg23710748 chr7:124431027 NA 0.38 6.08 0.32 3.42e-9 Cutaneous malignant melanoma; CRC cis rs9463078 0.625 rs1891412 chr6:44760642 T/C cg25276700 chr6:44698697 NA 0.28 6.78 0.35 5.7e-11 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg01897823 chr17:76356232 SOCS3 0.44 6.4 0.33 5.27e-10 Intelligence (multi-trait analysis); CRC cis rs2204008 0.683 rs7305703 chr12:38138381 T/C cg26384229 chr12:38710491 ALG10B 0.67 9.35 0.46 1.35e-18 Bladder cancer; CRC trans rs7615952 0.673 rs34209763 chr3:125599595 G/A cg07211511 chr3:129823064 LOC729375 -1.08 -13.72 -0.6 3.4e-34 Blood pressure (smoking interaction); CRC cis rs7809950 1.000 rs2712189 chr7:107195747 G/A cg23024343 chr7:107201750 COG5 -0.61 -8.54 -0.43 4.92e-16 Coronary artery disease; CRC cis rs6445525 1.000 rs4688631 chr3:65994050 C/T cg06109867 chr3:66002991 MAGI1 -0.38 -6.17 -0.32 2.03e-9 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs8072100 0.701 rs8078309 chr17:45774072 T/C cg08085267 chr17:45401833 C17orf57 -0.45 -6.62 -0.34 1.43e-10 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs7909074 0.509 rs2183994 chr10:45389940 T/C cg05187965 chr10:45406764 TMEM72 -0.34 -6.99 -0.36 1.58e-11 Mean corpuscular volume; CRC cis rs2032447 0.901 rs2213284 chr6:26031868 G/A cg26028573 chr6:26043587 HIST1H2BB 0.5 7.37 0.38 1.43e-12 Intelligence (multi-trait analysis); CRC cis rs780096 0.506 rs1728922 chr2:27644464 A/C cg02592271 chr2:27665507 KRTCAP3 -0.27 -6.16 -0.32 2.08e-9 Total body bone mineral density; CRC cis rs765787 0.530 rs1706830 chr15:45516229 G/A cg24006582 chr15:45444508 DUOX1 -0.57 -8.75 -0.43 1.15e-16 Uric acid levels; CRC cis rs10504229 0.815 rs72650877 chr8:58164510 T/C cg11062466 chr8:58055876 NA 0.45 5.81 0.3 1.49e-8 Developmental language disorder (linguistic errors); CRC cis rs4253772 0.614 rs11090859 chr22:46687460 T/G cg09491104 chr22:46646882 C22orf40 -0.38 -5.84 -0.31 1.25e-8 LDL cholesterol;Cholesterol, total; CRC cis rs10256972 0.732 rs12701856 chr7:1107707 C/T cg23708337 chr7:1209742 NA 0.39 5.82 0.31 1.36e-8 Longevity;Endometriosis; CRC cis rs9311474 0.508 rs11718420 chr3:52611413 T/C cg08222913 chr3:52553049 STAB1 -0.34 -6.45 -0.34 4e-10 Electroencephalogram traits; CRC cis rs7811142 0.779 rs28680963 chr7:99905475 C/G cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.87 10.98 0.52 4.29e-24 Platelet count; CRC cis rs924607 1.000 rs1697978 chr5:642829 A/G cg04221910 chr5:616842 CEP72 0.4 6.54 0.34 2.39e-10 Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia; CRC cis rs12142240 0.698 rs6679898 chr1:46820589 A/C cg14993813 chr1:46806288 NSUN4 -0.49 -6.22 -0.32 1.55e-9 Menopause (age at onset); CRC cis rs10131894 0.611 rs175001 chr14:75436452 A/C cg08847533 chr14:75593920 NEK9 0.68 10.64 0.51 6.45e-23 Coronary artery disease; CRC cis rs9467603 1.000 rs9467613 chr6:25812641 T/C cg08501292 chr6:25962987 TRIM38 1.08 9.37 0.46 1.19e-18 Intelligence (multi-trait analysis); CRC cis rs7618915 0.547 rs10780035 chr3:52764624 C/T cg08222913 chr3:52553049 STAB1 -0.33 -6.02 -0.31 4.78e-9 Bipolar disorder; CRC cis rs9534288 0.699 rs2146885 chr13:46659853 A/G cg15192986 chr13:46630673 CPB2 -0.68 -8.68 -0.43 1.83e-16 Blood protein levels; CRC cis rs4664293 0.801 rs7607143 chr2:160584761 T/C cg08347373 chr2:160653686 CD302 -0.35 -5.61 -0.3 4.36e-8 Monocyte percentage of white cells; CRC cis rs514406 0.929 rs2607095 chr1:53325639 T/C cg25767906 chr1:53392781 SCP2 -0.46 -7.39 -0.38 1.26e-12 Monocyte count; CRC cis rs6964587 1.000 rs2075881 chr7:91734552 T/C cg17063962 chr7:91808500 NA 0.83 14.44 0.62 5.96e-37 Breast cancer; CRC cis rs875971 0.862 rs937494 chr7:65764678 T/A cg12463550 chr7:65579703 CRCP -0.52 -7.37 -0.38 1.36e-12 Aortic root size; CRC cis rs1728785 1.000 rs1728780 chr16:68567642 G/C cg02972257 chr16:68554789 NA -0.58 -7.15 -0.37 5.78e-12 Ulcerative colitis; CRC cis rs8072100 0.701 rs2013383 chr17:45791123 T/G cg08085267 chr17:45401833 C17orf57 -0.44 -6.58 -0.34 1.88e-10 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs4555082 0.874 rs2245329 chr14:105719181 T/C cg10792982 chr14:105748885 BRF1 0.39 6.64 0.34 1.27e-10 Mean platelet volume;Platelet distribution width; CRC cis rs1552244 1.000 rs6781811 chr3:10121922 A/G cg08888203 chr3:10149979 C3orf24 -0.7 -9.92 -0.48 1.87e-20 Alzheimer's disease; CRC cis rs11711311 0.955 rs7617313 chr3:113391740 T/G cg15478005 chr3:113465772 ATP6V1A;NAA50 0.47 6.26 0.33 1.19e-9 IgG glycosylation; CRC cis rs35264875 0.950 rs35337391 chr11:68854012 A/G cg01993067 chr11:68851601 TPCN2 0.56 6.31 0.33 9.23e-10 Blond vs. brown hair color; CRC cis rs4731207 0.596 rs2219953 chr7:124671915 A/C cg23710748 chr7:124431027 NA -0.43 -6.68 -0.35 1.01e-10 Cutaneous malignant melanoma; CRC cis rs10504229 1.000 rs66672857 chr8:58179817 G/C cg01721255 chr8:58191610 C8orf71 0.49 6.17 0.32 2e-9 Developmental language disorder (linguistic errors); CRC cis rs4713118 0.869 rs9283880 chr6:27715243 A/C cg06470822 chr6:28175283 NA 0.72 10.34 0.5 6.75e-22 Parkinson's disease; CRC trans rs2898290 0.622 rs1478890 chr8:11355602 C/G cg06636001 chr8:8085503 FLJ10661 -0.42 -6.39 -0.33 5.8e-10 Systolic blood pressure; CRC cis rs68170813 0.559 rs80307895 chr7:106907781 T/A cg02696742 chr7:106810147 HBP1 -0.61 -6.7 -0.35 9.26e-11 Coronary artery disease; CRC trans rs7824557 0.527 rs2736296 chr8:11234844 G/A cg06636001 chr8:8085503 FLJ10661 -0.45 -6.84 -0.35 3.9e-11 Retinal vascular caliber; CRC cis rs1784581 0.651 rs1784589 chr6:162389571 A/G cg17173639 chr6:162384350 PARK2 -0.71 -11.88 -0.55 2.51e-27 Itch intensity from mosquito bite; CRC cis rs2730245 0.527 rs2036582 chr7:158701708 A/T cg24397884 chr7:158709396 WDR60 0.84 10.71 0.51 3.63e-23 Height; CRC trans rs2840044 1.000 rs11653310 chr17:33893378 C/G cg19694781 chr19:47549865 TMEM160 -0.47 -7.5 -0.38 6.15e-13 Response to radiotherapy in cancer (late toxicity); CRC cis rs7208859 0.623 rs73267858 chr17:29059737 A/G cg01831904 chr17:28903510 LRRC37B2 -0.61 -6.22 -0.32 1.52e-9 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs6938 0.534 rs12913293 chr15:75184458 G/C cg09165964 chr15:75287851 SCAMP5 0.56 8.96 0.44 2.51e-17 Breast cancer; CRC cis rs9910055 0.762 rs2240226 chr17:42266218 C/T cg10896456 chr17:42255109 ASB16;C17orf65 0.46 7.48 0.38 6.61e-13 Total body bone mineral density; CRC cis rs72781680 0.660 rs72780104 chr2:23983715 A/G cg08917208 chr2:24149416 ATAD2B 0.9 8.78 0.44 9.3e-17 Lymphocyte counts; CRC cis rs11971779 0.816 rs11979272 chr7:139074069 C/T cg07862535 chr7:139043722 LUC7L2 1.05 12.53 0.57 1.03e-29 Diisocyanate-induced asthma; CRC cis rs13144136 0.687 rs61796835 chr4:10656807 C/A cg10242279 chr4:10666415 CLNK -0.38 -6.5 -0.34 2.93e-10 Resistance to antihypertensive treatment in hypertension; CRC cis rs56104184 0.723 rs73063522 chr19:49408358 C/G cg21252483 chr19:49399788 TULP2 -0.42 -6.69 -0.35 9.49e-11 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; CRC cis rs7727544 0.684 rs274560 chr5:131719450 T/C cg07395648 chr5:131743802 NA 0.42 6.65 0.34 1.25e-10 Blood metabolite levels; CRC cis rs4272321 1 rs4272321 chr7:157951835 A/G cg02161503 chr7:157955692 PTPRN2 0.42 7.29 0.37 2.29e-12 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; CRC cis rs6951245 1.000 rs78308415 chr7:1072634 G/A cg18402987 chr7:1209562 NA 0.64 6.79 0.35 5.14e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs317865 0.737 rs28483204 chr4:16205098 A/G cg04764131 chr4:16228633 TAPT1;FLJ39653 0.6 5.65 0.3 3.41e-8 Kidney disease (early stage) in type 1 diabetes; CRC cis rs1065852 0.526 rs9611711 chr22:42410695 G/A cg00645731 chr22:42541494 CYP2D7P1 0.4 6.94 0.36 2.1e-11 Response to serotonin reuptake inhibitors in major depressive disorder (plasma drug and metabolite levels); CRC cis rs2276314 0.857 rs8087539 chr18:33631537 C/T cg05985134 chr18:33552581 C18orf21 0.5 7.02 0.36 1.3e-11 Endometriosis;Drug-induced torsades de pointes; CRC cis rs763121 0.853 rs138713 chr22:39142615 T/C cg06544989 chr22:39130855 UNC84B 0.51 7.73 0.39 1.33e-13 Menopause (age at onset); CRC cis rs7249142 0.562 rs10854009 chr19:19284705 A/C cg08207377 chr19:19281140 LOC729991-MEF2B;MEF2B -0.38 -6.14 -0.32 2.33e-9 IgG glycosylation; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg13301069 chr11:6624877 ILK;RRP8 0.36 6.28 0.33 1.09e-9 Liver disease severity in Alagille syndrome; CRC cis rs1506636 1.000 rs2299984 chr7:123356921 G/T cg03229431 chr7:123269106 ASB15 0.74 11.92 0.55 1.86e-27 Plateletcrit;Platelet count; CRC cis rs2286885 0.965 rs4837092 chr9:129250251 T/C cg15282417 chr9:129245246 FAM125B 0.47 8.7 0.43 1.57e-16 Intraocular pressure; CRC cis rs7246865 0.954 rs55957788 chr19:17207851 G/A cg19418318 chr19:17219073 MYO9B 0.51 8.79 0.44 8.54e-17 Reticulocyte fraction of red cells; CRC cis rs7618915 0.547 rs11130317 chr3:52731483 C/T cg15147215 chr3:52552868 STAB1 -0.62 -10.12 -0.49 3.99e-21 Bipolar disorder; CRC cis rs9322193 0.884 rs10872646 chr6:150067675 A/G cg05861140 chr6:150128134 PCMT1 -0.39 -6.26 -0.33 1.21e-9 Lung cancer; CRC cis rs2204008 0.744 rs66474616 chr12:38461564 G/A cg13010199 chr12:38710504 ALG10B 0.47 5.99 0.31 5.57e-9 Bladder cancer; CRC cis rs10256972 0.591 rs6968988 chr7:1169619 A/G cg26608667 chr7:1196370 ZFAND2A 0.4 6.56 0.34 2.1e-10 Longevity;Endometriosis; CRC cis rs78456975 1.000 rs13400784 chr2:1564473 T/A cg12573674 chr2:1569213 NA -0.77 -8.03 -0.4 1.76e-14 Placebo response in major depressive disorder (% change in symptom score); CRC cis rs2717559 0.522 rs10956987 chr8:143886613 T/C cg04969067 chr8:143858791 LYNX1 -0.73 -13.05 -0.58 1.17e-31 Urinary tract infection frequency; CRC cis rs6598955 0.671 rs57386998 chr1:26569821 G/A cg04990556 chr1:26633338 UBXN11 0.56 6.02 0.32 4.53e-9 Obesity-related traits; CRC cis rs911119 0.818 rs56077567 chr20:23591087 T/C cg16589663 chr20:23618590 CST3 0.45 6.3 0.33 9.76e-10 Chronic kidney disease; CRC cis rs1005277 0.579 rs116912400 chr10:38479207 G/T cg25427524 chr10:38739819 LOC399744 -0.77 -13.75 -0.6 2.69e-34 Extrinsic epigenetic age acceleration; CRC cis rs2737618 1.000 rs2737618 chr1:200107425 C/T cg21825944 chr1:200113062 NR5A2 -0.44 -5.62 -0.3 4.16e-8 Uric acid levels; CRC cis rs6963495 0.818 rs818619 chr7:105172505 A/T cg19920283 chr7:105172520 RINT1 0.54 6.66 0.34 1.12e-10 Bipolar disorder (body mass index interaction); CRC cis rs2898681 0.614 rs962416 chr4:53695657 G/T cg00791764 chr4:53727839 RASL11B -0.39 -5.8 -0.3 1.55e-8 Optic nerve measurement (cup area); CRC cis rs796364 0.951 rs12613687 chr2:200999256 C/T cg25936922 chr2:200820526 C2orf60;C2orf47 -0.72 -7.76 -0.39 1.1e-13 Schizophrenia; CRC cis rs1552244 0.935 rs66493421 chr3:10092569 G/A cg08888203 chr3:10149979 C3orf24 0.66 7.81 0.4 7.74e-14 Alzheimer's disease; CRC cis rs9682041 0.740 rs6444929 chr3:170150076 C/T cg11886554 chr3:170076028 SKIL 0.96 9.8 0.48 4.58e-20 Glomerular filtration rate in non diabetics (creatinine);Glomerular filtration rate (creatinine); CRC cis rs6541297 1.000 rs6686680 chr1:230280522 T/C cg05784532 chr1:230284198 GALNT2 0.48 6.54 0.34 2.4e-10 Coronary artery disease; CRC cis rs7095944 0.614 rs7898003 chr10:126451385 G/A cg08799069 chr10:126477246 METTL10 -0.44 -6.95 -0.36 1.99e-11 Asthma; CRC cis rs13082711 1.000 rs6791212 chr3:27507179 C/A cg02860705 chr3:27208620 NA 0.62 8.5 0.42 6.85e-16 Systolic blood pressure;Diastolic blood pressure;Blood pressure; CRC cis rs651907 0.535 rs35810977 chr3:101531380 G/A cg12386194 chr3:101231763 SENP7 0.51 7.27 0.37 2.68e-12 Colorectal cancer; CRC cis rs11098499 0.754 rs2964 chr4:120240131 T/C cg09307838 chr4:120376055 NA 0.62 9.75 0.47 6.92e-20 Corneal astigmatism; CRC cis rs1008375 0.932 rs6845288 chr4:17665498 A/T cg16339924 chr4:17578868 LAP3 -0.53 -6.56 -0.34 2.15e-10 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs3956705 0.798 rs1045530 chr7:32908135 C/G cg05721444 chr7:32995514 FKBP9 -0.46 -6.77 -0.35 6.04e-11 Red cell distribution width; CRC cis rs1552244 0.832 rs61056817 chr3:10027641 C/T cg16606324 chr3:10149918 C3orf24 0.55 6.51 0.34 2.74e-10 Alzheimer's disease; CRC cis rs798554 0.757 rs960273 chr7:2857876 T/C cg04166393 chr7:2884313 GNA12 0.51 6.82 0.35 4.3e-11 Height; CRC cis rs1023500 0.505 rs134885 chr22:42673811 C/G cg15557168 chr22:42548783 NA -0.39 -6.74 -0.35 7.25e-11 Schizophrenia; CRC cis rs7208859 0.673 rs61348930 chr17:29221763 C/T cg01831904 chr17:28903510 LRRC37B2 -0.56 -5.83 -0.31 1.35e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs60871478 0.786 rs12532534 chr7:831891 G/A cg05535760 chr7:792225 HEATR2 -1.02 -12.73 -0.57 1.84e-30 Cerebrospinal P-tau181p levels; CRC cis rs6088590 1.000 rs6120748 chr20:33458284 T/G cg08999081 chr20:33150536 PIGU 0.48 7.96 0.4 2.86e-14 Coronary artery disease; CRC cis rs7591163 0.959 rs10933217 chr2:228716226 T/C cg00063174 chr2:228736253 WDR69 -0.51 -6.9 -0.36 2.6e-11 Blood pressure; CRC cis rs2882667 0.755 rs55650316 chr5:138467292 C/G cg09476006 chr5:138032270 NA 0.42 6.4 0.33 5.43e-10 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs11105298 0.891 rs11105310 chr12:89918677 C/A cg00757033 chr12:89920650 WDR51B 0.37 6.08 0.32 3.37e-9 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; CRC cis rs916888 0.773 rs1378358 chr17:44787312 C/T cg17911788 chr17:44343683 NA -0.67 -7.55 -0.38 4.25e-13 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs2153535 0.935 rs11243254 chr6:8381242 C/T cg07606381 chr6:8435919 SLC35B3 -0.43 -6.28 -0.33 1.04e-9 Motion sickness; CRC cis rs35264875 1.000 rs7110274 chr11:68842704 A/G cg03469862 chr11:68924853 NA 0.46 5.85 0.31 1.17e-8 Blond vs. brown hair color; CRC cis rs6662572 0.578 rs6662307 chr1:46287287 G/T cg08644498 chr1:46502608 NA 0.44 6.91 0.36 2.59e-11 Blood protein levels; CRC cis rs2075371 0.932 rs1862052 chr7:133981227 G/A cg02659138 chr7:134003124 SLC35B4 0.39 6.6 0.34 1.69e-10 Mean platelet volume; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg11721769 chr6:24495264 ALDH5A1 0.47 6.65 0.34 1.22e-10 Anxiety disorder; CRC cis rs694739 0.628 rs645078 chr11:64135298 A/C cg23796481 chr11:64053134 BAD;GPR137 0.5 7.02 0.36 1.28e-11 Alopecia areata;Crohn's disease;Psoriasis vulgaris; CRC cis rs1552244 1.000 rs2272125 chr3:10138069 A/C cg00166722 chr3:10149974 C3orf24 0.62 8.67 0.43 1.99e-16 Alzheimer's disease; CRC cis rs881375 0.967 rs2109896 chr9:123683106 C/T cg09586646 chr9:123605570 PSMD5;LOC253039 0.51 7.02 0.36 1.29e-11 Rheumatoid arthritis; CRC cis rs2204008 0.806 rs1589382 chr12:38408565 T/A cg13010199 chr12:38710504 ALG10B 0.47 6.3 0.33 9.58e-10 Bladder cancer; CRC cis rs738322 0.577 rs6001034 chr22:38558459 A/G cg25457927 chr22:38595422 NA -0.32 -6.61 -0.34 1.58e-10 Cutaneous nevi; CRC cis rs1448094 0.511 rs17279338 chr12:86162874 G/A cg25456477 chr12:86230367 RASSF9 0.38 6.43 0.33 4.41e-10 Major depressive disorder; CRC cis rs9733 0.744 rs3754211 chr1:150951857 G/A cg15448220 chr1:150897856 SETDB1 0.41 6.05 0.32 3.94e-9 Tonsillectomy; CRC cis rs7224737 0.750 rs13380830 chr17:40297658 C/G cg20291162 chr17:40259547 DHX58 -0.44 -5.69 -0.3 2.87e-8 Fibrinogen levels; CRC cis rs13063635 0.831 rs13433997 chr3:46049765 T/C cg12691230 chr3:46064611 XCR1 -0.57 -6.23 -0.32 1.43e-9 Eosinophil percentage of granulocytes; CRC cis rs13118159 0.778 rs12650998 chr4:1338832 T/C cg15763984 chr4:1342303 KIAA1530 0.36 6.12 0.32 2.65e-9 Longevity; CRC cis rs6502050 0.769 rs9904237 chr17:80119664 G/A cg19223190 chr17:80058835 NA 0.39 6.23 0.32 1.43e-9 Life satisfaction; CRC cis rs6681460 1.000 rs6588207 chr1:67066555 A/G cg02459107 chr1:67143332 SGIP1 0.46 8.17 0.41 6.53e-15 Presence of antiphospholipid antibodies; CRC cis rs9381040 0.626 rs2272986 chr6:41037778 C/T cg03644281 chr6:41068752 NFYA;LOC221442 -0.46 -6.52 -0.34 2.6200000000000003e-10 Alzheimer's disease (late onset); CRC trans rs4332037 0.575 rs55952733 chr7:2070680 G/A cg11693508 chr17:37793320 STARD3 0.61 7.18 0.37 4.7e-12 Bipolar disorder; CRC cis rs4665809 0.590 rs1469523 chr2:26474631 T/A cg22920501 chr2:26401640 FAM59B 0.85 12.21 0.56 1.54e-28 Gut microbiome composition (summer); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg02950623 chr16:14379524 NA 0.37 6.19 0.32 1.76e-9 Liver disease severity in Alagille syndrome; CRC cis rs1448094 0.549 rs12308898 chr12:86233678 G/A cg19622623 chr12:86230825 RASSF9 -0.4 -6.26 -0.33 1.18e-9 Major depressive disorder; CRC cis rs4969178 0.965 rs2292642 chr17:76395430 C/T cg20026190 chr17:76395443 PGS1 0.4 6.22 0.32 1.47e-9 HDL cholesterol levels; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg17128646 chr2:198363565 HSPD1;HSPE1 0.46 6.09 0.32 3.13e-9 Anxiety disorder; CRC cis rs2075371 0.501 rs1643043 chr7:134013902 C/T cg11752832 chr7:134001865 SLC35B4 0.43 6.2 0.32 1.7e-9 Mean platelet volume; CRC cis rs2380220 0.808 rs2263180 chr6:95902309 G/A cg04719120 chr6:96025338 MANEA -0.53 -5.88 -0.31 9.93e-9 Behavioural disinhibition (generation interaction); CRC cis rs9733 0.596 rs56058687 chr1:150635066 C/T cg15448220 chr1:150897856 SETDB1 0.45 6.43 0.33 4.42e-10 Tonsillectomy; CRC cis rs4727027 0.866 rs3927307 chr7:148774869 C/T cg12479418 chr7:148823350 ZNF425;ZNF398 0.46 6.24 0.33 1.34e-9 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC cis rs2842992 0.513 rs7759086 chr6:160193853 A/G cg11366901 chr6:160182831 ACAT2 0.74 11.41 0.53 1.27e-25 Age-related macular degeneration (geographic atrophy); CRC cis rs9837602 0.507 rs793452 chr3:99529523 C/T cg07805332 chr3:99536008 MIR548G;C3orf26 -0.55 -8.29 -0.42 2.85e-15 Breast cancer; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg02296128 chr13:45694882 GTF2F2 0.44 6.1 0.32 3e-9 Response to antipsychotic treatment; CRC cis rs9467603 1.000 rs9467607 chr6:25809477 G/A cg08501292 chr6:25962987 TRIM38 1.08 9.37 0.46 1.19e-18 Intelligence (multi-trait analysis); CRC cis rs6565180 0.962 rs11642676 chr16:30371655 C/G cg17640201 chr16:30407289 ZNF48 -0.77 -12.18 -0.56 2.08e-28 Tonsillectomy; CRC cis rs12505749 0.542 rs66858948 chr4:57334142 C/G cg06922635 chr4:57371607 ARL9 -0.52 -5.63 -0.3 3.83e-8 Airflow obstruction; CRC cis rs10504229 0.610 rs7011877 chr8:58147181 C/T cg05313129 chr8:58192883 C8orf71 -0.4 -5.89 -0.31 9.72e-9 Developmental language disorder (linguistic errors); CRC cis rs12893668 0.603 rs12896171 chr14:104135966 A/G cg01849466 chr14:104193079 ZFYVE21 -0.41 -6.05 -0.32 3.98e-9 Reticulocyte count; CRC cis rs2404602 0.735 rs283789 chr15:76777577 G/A cg23625390 chr15:77176239 SCAPER 0.77 12.14 0.56 2.73e-28 Blood metabolite levels; CRC cis rs902774 0.585 rs7399070 chr12:53355678 G/T cg25025879 chr12:53359317 NA -0.84 -7.97 -0.4 2.62e-14 Prostate cancer; CRC cis rs9303401 0.659 rs12935851 chr17:56600244 C/A cg02118635 chr17:56770003 RAD51C;TEX14 0.81 9.94 0.48 1.52e-20 Cognitive test performance; CRC cis rs921968 0.643 rs4674321 chr2:219511368 G/A cg02176678 chr2:219576539 TTLL4 0.52 8.82 0.44 6.7e-17 Mean corpuscular hemoglobin concentration; CRC trans rs9858542 0.953 rs11719996 chr3:49525958 T/C cg21659725 chr3:3221576 CRBN -0.66 -8.98 -0.44 2.18e-17 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs9788333 0.762 rs4441120 chr13:21886863 T/A cg23743428 chr13:21893420 NA -0.45 -8.92 -0.44 3.38e-17 Thiazide-induced adverse metabolic effects in hypertensive patients; CRC cis rs1018836 0.608 rs2142147 chr8:91468200 A/G cg16814680 chr8:91681699 NA -0.53 -8.23 -0.41 4.4e-15 Ejection fraction in Tripanosoma cruzi seropositivity; CRC cis rs651907 0.557 rs1031710 chr3:101463895 C/T cg11279151 chr3:101281821 RG9MTD1 -0.54 -7.4 -0.38 1.12e-12 Colorectal cancer; CRC trans rs5756813 0.811 rs4396807 chr22:38138379 G/C cg19894588 chr14:64061835 NA -0.58 -8.46 -0.42 8.74e-16 Optic cup area;Vertical cup-disc ratio; CRC cis rs17270561 1.000 rs12200962 chr6:25828986 T/C cg16482183 chr6:26056742 HIST1H1C 0.93 10.45 0.5 2.97e-22 Iron status biomarkers; CRC cis rs1348850 0.914 rs1374437 chr2:178363423 T/C cg02961200 chr2:178257176 LOC100130691;AGPS 0.62 9.08 0.45 1.02e-17 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs7193541 0.929 rs12933037 chr16:74660174 G/A cg01733217 chr16:74700730 RFWD3 0.84 15.43 0.65 8.51e-41 Multiple myeloma; CRC cis rs4746091 0.951 rs1868006 chr10:73403324 C/T cg22763136 chr10:73395000 CDH23 0.41 6.03 0.32 4.32e-9 Selective IgA deficiency; CRC cis rs875971 0.862 rs908915 chr7:65614651 G/T cg11764359 chr7:65958608 NA -0.6 -9.24 -0.45 3.19e-18 Aortic root size; CRC cis rs17152411 0.895 rs7080330 chr10:126585673 A/G cg07906193 chr10:126599966 NA 0.56 6.33 0.33 7.97e-10 Height; CRC cis rs17376456 0.877 rs10057605 chr5:93443950 T/G cg21475434 chr5:93447410 FAM172A 0.74 7.54 0.38 4.59e-13 Diabetic retinopathy; CRC cis rs853679 0.517 rs9368558 chr6:28133306 A/G cg12963246 chr6:28129442 ZNF389 0.49 5.7 0.3 2.71e-8 Depression; CRC cis rs1568889 0.838 rs4614434 chr11:28302234 C/A cg06544937 chr11:28130018 METT5D1;KIF18A 0.91 15.36 0.65 1.59e-40 Bipolar disorder; CRC cis rs7927771 0.832 rs4752990 chr11:47410393 G/A cg05585544 chr11:47624801 NA -0.54 -9.51 -0.46 4.15e-19 Subjective well-being; CRC cis rs2836950 0.565 rs2150413 chr21:40614878 C/T cg17971929 chr21:40555470 PSMG1 -0.55 -7.79 -0.39 8.77e-14 Menarche (age at onset); CRC cis rs7725052 0.609 rs11957215 chr5:40445681 A/G cg09067459 chr5:40385259 NA -0.4 -6.71 -0.35 8.37e-11 Pediatric autoimmune diseases; CRC cis rs1448094 1.000 rs4919776 chr12:86353763 T/C cg19622623 chr12:86230825 RASSF9 -0.38 -6.11 -0.32 2.89e-9 Major depressive disorder; CRC cis rs2302190 0.769 rs8082396 chr17:56632193 C/T cg12560992 chr17:57184187 TRIM37 0.52 6.03 0.32 4.34e-9 Vitamin D levels; CRC cis rs4332037 0.586 rs62442944 chr7:2015047 T/G cg21155852 chr7:2048760 MAD1L1 -0.53 -7.16 -0.37 5.38e-12 Bipolar disorder; CRC cis rs6570726 0.935 rs453609 chr6:145812332 T/C cg23711669 chr6:146136114 FBXO30 0.67 11.99 0.55 9.92e-28 Lobe attachment (rater-scored or self-reported); CRC cis rs887829 0.569 rs10179091 chr2:234657983 A/G cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.52 -8.25 -0.41 3.94e-15 Metabolic traits;Bilirubin levels;Cholelithiasis-related traits in sickle cell anemia;Metabolite levels;Total bilirubin levels in HIV-1 infection;Serum metabolite levels;Blood metabolite levels; CRC cis rs9649213 0.593 rs11766808 chr7:97915376 A/G cg21770322 chr7:97807741 LMTK2 0.54 9.03 0.45 1.52e-17 Prostate cancer (SNP x SNP interaction); CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg11403890 chr1:41708077 SCMH1 0.45 6.17 0.32 2.05e-9 Anxiety disorder; CRC cis rs11148252 0.875 rs9526913 chr13:52975837 T/C cg00495681 chr13:53174319 NA 0.55 8.34 0.42 2.08e-15 Lewy body disease; CRC cis rs9527 0.590 rs726010 chr10:104841977 C/T cg15744005 chr10:104629667 AS3MT -0.3 -5.83 -0.31 1.31e-8 Arsenic metabolism; CRC cis rs11212617 0.869 rs4754299 chr11:108025214 C/T cg01991180 chr11:108092276 ATM;NPAT 0.4 5.84 0.31 1.27e-8 Response to metformin in type 2 diabetes (glycemic); CRC cis rs3087591 1.000 rs2107360 chr17:29697901 C/A cg24425628 chr17:29625626 OMG;NF1 -0.84 -16.31 -0.67 2.94e-44 Hip circumference; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg15809230 chr15:75743753 SIN3A 0.45 6.17 0.32 2.03e-9 Anxiety disorder; CRC cis rs7772486 0.558 rs9497403 chr6:146054695 T/G cg05347473 chr6:146136440 FBXO30 -0.48 -6.94 -0.36 2.15e-11 Lobe attachment (rater-scored or self-reported); CRC cis rs1559088 0.847 rs6510348 chr19:33601946 G/A cg27124370 chr19:33622961 WDR88 0.44 6.12 0.32 2.64e-9 Bone ultrasound measurement (broadband ultrasound attenuation); CRC trans rs1814175 0.803 rs11040451 chr11:49650639 C/T cg15704280 chr7:45808275 SEPT13 -0.97 -18.29 -0.71 4.7e-52 Height; CRC cis rs2032447 0.798 rs807214 chr6:26061769 G/C cg12310025 chr6:25882481 NA -0.49 -6.85 -0.35 3.73e-11 Intelligence (multi-trait analysis); CRC cis rs17376456 0.825 rs10058331 chr5:93279115 T/G cg25358565 chr5:93447407 FAM172A 1.12 10.53 0.5 1.51e-22 Diabetic retinopathy; CRC cis rs875971 0.737 rs7803424 chr7:65880605 T/C cg12463550 chr7:65579703 CRCP 0.48 6.96 0.36 1.89e-11 Aortic root size; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg24702147 chr12:7071814 MIR141;MIR200C 0.24 6.15 0.32 2.2e-9 Response to antipsychotic treatment; CRC cis rs9296404 1 rs9296404 chr6:42925803 T/C cg10862848 chr6:42927986 GNMT -0.38 -9.07 -0.45 1.1e-17 Plasma homocysteine levels (post-methionine load test); CRC cis rs597539 0.616 rs473997 chr11:68639481 C/T cg06112835 chr11:68658793 MRPL21 0.49 7.67 0.39 2e-13 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg03672602 chr19:19754555 GMIP 0.48 6.1 0.32 2.95e-9 Thyroid stimulating hormone; CRC cis rs17666538 0.585 rs336444 chr8:633123 C/G cg07685180 chr8:600429 NA -0.54 -6.11 -0.32 2.83e-9 IgG glycosylation; CRC cis rs34172651 0.837 rs1978451 chr16:24818286 C/G cg06028605 chr16:24865363 SLC5A11 0.44 7.98 0.4 2.42e-14 Intelligence (multi-trait analysis); CRC trans rs1814175 0.669 rs10839315 chr11:49654406 G/A cg15704280 chr7:45808275 SEPT13 -0.73 -11.59 -0.54 2.71e-26 Height; CRC cis rs4665809 0.531 rs3892649 chr2:26457267 T/G cg04944784 chr2:26401820 FAM59B 0.85 11.05 0.52 2.29e-24 Gut microbiome composition (summer); CRC cis rs57920188 0.537 rs4440829 chr1:4080780 A/G cg10510935 chr1:4059661 NA -0.38 -5.99 -0.31 5.6e-9 Interleukin-17 levels; CRC cis rs2280630 0.529 rs6599274 chr3:39013948 T/C cg01426195 chr3:39028469 NA -0.43 -7.14 -0.37 5.92e-12 Verbal declarative memory; CRC cis rs4713118 0.513 rs200971 chr6:27858904 C/T cg23161317 chr6:28129485 ZNF389 0.44 6.04 0.32 4.22e-9 Parkinson's disease; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg16554516 chr1:206680868 RASSF5 0.39 6.59 0.34 1.72e-10 Liver disease severity in Alagille syndrome; CRC trans rs2727020 0.521 rs7946190 chr11:49521964 T/A cg11707556 chr5:10655725 ANKRD33B 0.47 7.56 0.38 4.01e-13 Coronary artery disease; CRC cis rs9311474 0.508 rs3796353 chr3:52593230 C/T cg08222913 chr3:52553049 STAB1 -0.34 -6.46 -0.34 3.7e-10 Electroencephalogram traits; CRC cis rs2153535 0.601 rs9502719 chr6:8541032 A/G cg07606381 chr6:8435919 SLC35B3 0.68 11.23 0.53 5.44e-25 Motion sickness; CRC cis rs9291683 0.620 rs7699512 chr4:10125808 C/T cg11266682 chr4:10021025 SLC2A9 -0.44 -8.69 -0.43 1.73e-16 Bone mineral density; CRC trans rs9929218 0.954 rs17715799 chr16:68830511 A/T cg04657470 chr2:198365150 HSPE1;HSPD1 -0.77 -10.95 -0.52 5.15e-24 Colorectal cancer; CRC cis rs2576037 0.526 rs1789152 chr18:44433092 G/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.54 9.26 0.45 2.71e-18 Personality dimensions; CRC cis rs12135062 0.851 rs2651927 chr1:3101762 A/C cg21609526 chr1:3105151 PRDM16 -0.54 -9.4 -0.46 9.33e-19 Migraine; CRC cis rs9322193 0.923 rs2184369 chr6:150097817 G/A cg00933542 chr6:150070202 PCMT1 0.28 5.63 0.3 3.86e-8 Lung cancer; CRC cis rs17125944 0.505 rs80211268 chr14:53265483 C/G cg00686598 chr14:53173677 PSMC6 1.25 11.62 0.54 2.11e-26 Alzheimer's disease (late onset); CRC cis rs78456975 1.000 rs13400784 chr2:1564473 T/A cg01028140 chr2:1542097 TPO -0.56 -5.8 -0.3 1.53e-8 Placebo response in major depressive disorder (% change in symptom score); CRC cis rs514406 0.607 rs1930305 chr1:53195481 G/T cg27535305 chr1:53392650 SCP2 0.36 6.44 0.33 4.31e-10 Monocyte count; CRC cis rs597539 0.654 rs619727 chr11:68627535 A/G cg04772025 chr11:68637568 NA 0.52 8.18 0.41 6.29e-15 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs754466 1.000 rs12220311 chr10:79681507 C/T cg17075019 chr10:79541650 NA -0.74 -10.25 -0.49 1.45e-21 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs3782089 0.744 rs11545200 chr11:65319751 G/A cg21890820 chr11:65308645 LTBP3 0.9 6.33 0.33 7.82e-10 Height; CRC cis rs10791323 0.569 rs10791328 chr11:133713730 A/G cg06766960 chr11:133703094 NA -0.36 -5.96 -0.31 6.66e-9 Childhood ear infection; CRC cis rs908922 0.651 rs7529157 chr1:152531365 C/A cg09873164 chr1:152488093 CRCT1 0.36 6.16 0.32 2.14e-9 Hair morphology; CRC cis rs875971 0.793 rs460678 chr7:65527200 C/G cg11764359 chr7:65958608 NA 0.58 9.04 0.45 1.36e-17 Aortic root size; CRC cis rs7264396 0.561 rs6060753 chr20:34598430 C/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.59 -8.4 -0.42 1.34e-15 Total cholesterol levels; CRC cis rs7584330 0.666 rs72620818 chr2:238354652 G/A cg16989719 chr2:238392110 NA -0.39 -6.43 -0.33 4.48e-10 Prostate cancer; CRC trans rs2243480 1.000 rs313831 chr7:65551226 C/T cg10756647 chr7:56101905 PSPH 0.68 7.3 0.37 2.14e-12 Diabetic kidney disease; CRC cis rs731174 0.722 rs553888 chr1:38152509 C/G cg06917450 chr1:38156652 C1orf109 -0.5 -7.16 -0.37 5.37e-12 Prostate cancer (SNP x SNP interaction); CRC cis rs394563 0.625 rs394526 chr6:149796975 T/G cg07828024 chr6:149772892 ZC3H12D -0.39 -6.55 -0.34 2.25e-10 Dupuytren's disease; CRC cis rs815815 0.608 rs815808 chr2:47381097 C/T cg27223769 chr2:47403360 CALM2 0.72 8.89 0.44 4.1e-17 Dialysis-related mortality; CRC cis rs2228479 0.557 rs62054639 chr16:89821489 C/T cg19635926 chr16:89946313 TCF25 0.63 5.68 0.3 3.01e-8 Skin colour saturation; CRC cis rs938554 0.612 rs28592748 chr4:9998605 T/C cg00071950 chr4:10020882 SLC2A9 0.49 6.84 0.35 3.78e-11 Blood metabolite levels; CRC cis rs1045714 0.895 rs73043182 chr7:2646005 C/T cg24848437 chr7:2645542 IQCE 0.58 6.14 0.32 2.43e-9 Urate levels in lean individuals; CRC cis rs798766 1.000 rs798744 chr4:1714684 C/A cg25714306 chr4:1656736 FAM53A -0.33 -5.84 -0.31 1.23e-8 Bladder cancer;Urinary bladder cancer; CRC cis rs10208940 0.920 rs12713643 chr2:68724129 C/G cg12452813 chr2:68675892 NA 0.51 6.35 0.33 7.33e-10 Urate levels in lean individuals; CRC trans rs3758141 0.527 rs13273408 chr8:18700405 G/A cg08576827 chr20:9075493 PLCB4 -0.76 -6.18 -0.32 1.91e-9 Body mass index (change over time) in gastrointestinal cancer; CRC cis rs7614311 0.731 rs1053338 chr3:63967900 A/G cg22134162 chr3:63841271 THOC7 -0.57 -5.82 -0.31 1.37e-8 Lung function (FVC);Lung function (FEV1); CRC cis rs11579220 1 rs11579220 chr1:205144363 G/T cg00857998 chr1:205179979 DSTYK 0.49 6.71 0.35 8.69e-11 White blood cell count (basophil);Basophil percentage of white cells; CRC cis rs9796 0.717 rs2947494 chr15:41375741 C/T cg18705301 chr15:41695430 NDUFAF1 -0.38 -6.42 -0.33 4.69e-10 Menopause (age at onset); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg24450365 chr7:89874355 C7orf63 0.44 6.55 0.34 2.2e-10 Intelligence (multi-trait analysis); CRC trans rs2303319 0.504 rs57419108 chr2:162311357 G/C cg04145477 chr6:107077629 RTN4IP1;QRSL1 -0.84 -6.27 -0.33 1.13e-9 Cognitive function; CRC cis rs4604732 0.631 rs74154675 chr1:247625836 G/A cg02104434 chr1:247694406 LOC148824;OR2C3 0.6 8.82 0.44 6.67e-17 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CRC cis rs9527 0.622 rs12779263 chr10:104886533 G/T cg15744005 chr10:104629667 AS3MT -0.33 -6.4 -0.33 5.21e-10 Arsenic metabolism; CRC cis rs67311347 1.000 rs112619360 chr3:40432645 T/G cg24209194 chr3:40518798 ZNF619 0.39 5.71 0.3 2.59e-8 Renal cell carcinoma; CRC cis rs10782582 0.609 rs1689270 chr1:76390937 A/G cg10523679 chr1:76189770 ACADM -0.42 -5.93 -0.31 7.47e-9 Daytime sleep phenotypes; CRC cis rs4563143 0.647 rs117442062 chr19:29256823 A/T cg12756686 chr19:29218302 NA 0.6 8.96 0.44 2.38e-17 Methadone dose in opioid dependence; CRC cis rs1046896 0.739 rs2379358 chr17:80741612 G/A cg16060761 chr17:80687452 NA -0.47 -6.29 -0.33 9.95e-10 Glycated hemoglobin levels; CRC cis rs921968 0.678 rs500422 chr2:219432995 C/A cg02176678 chr2:219576539 TTLL4 0.5 7.93 0.4 3.44e-14 Mean corpuscular hemoglobin concentration; CRC cis rs7618915 0.547 rs13064064 chr3:52657002 T/C cg18099408 chr3:52552593 STAB1 -0.43 -7.1 -0.36 7.92e-12 Bipolar disorder; CRC cis rs4268898 0.722 rs12185638 chr2:24382030 C/G cg06627628 chr2:24431161 ITSN2 0.46 6.79 0.35 5.3e-11 Asthma; CRC cis rs172166 0.694 rs1225716 chr6:28113746 A/C cg10876282 chr6:28092338 ZSCAN16 0.5 6.71 0.35 8.65e-11 Cardiac Troponin-T levels; CRC cis rs7932354 0.583 rs7934421 chr11:46852753 T/A cg19486271 chr11:47235900 DDB2 -0.43 -6.54 -0.34 2.31e-10 Bone mineral density (hip);Bone mineral density; CRC cis rs11190604 1.000 rs11190541 chr10:102203071 A/G cg07570687 chr10:102243282 WNT8B 0.44 5.64 0.3 3.61e-8 Palmitoleic acid (16:1n-7) levels; CRC cis rs11792861 0.888 rs75543406 chr9:111816903 A/T cg05043794 chr9:111880884 C9orf5 -0.37 -6.58 -0.34 1.87e-10 Menarche (age at onset); CRC cis rs8060686 0.545 rs12444313 chr16:68254404 A/C cg26727032 chr16:67993705 SLC12A4 -0.57 -6.22 -0.32 1.55e-9 HDL cholesterol;Metabolic syndrome; CRC cis rs9399135 0.967 rs11756988 chr6:135347595 A/G cg24558204 chr6:135376177 HBS1L 0.52 8.23 0.41 4.52e-15 Red blood cell count; CRC cis rs796364 0.806 rs77853713 chr2:201006880 A/T cg25936922 chr2:200820526 C2orf60;C2orf47 -0.67 -6.3 -0.33 9.32e-10 Schizophrenia; CRC cis rs1448094 0.809 rs11117103 chr12:86314431 C/T cg19622623 chr12:86230825 RASSF9 -0.4 -6.55 -0.34 2.24e-10 Major depressive disorder; CRC cis rs863345 0.604 rs11264984 chr1:158464990 C/T cg12129480 chr1:158549410 OR10X1 -0.3 -6.29 -0.33 9.9e-10 Pneumococcal bacteremia; CRC cis rs12519773 0.555 rs2578490 chr5:92389236 C/T cg18783429 chr5:92414398 NA 0.35 7.47 0.38 7.46e-13 Migraine; CRC cis rs12044355 0.927 rs61835382 chr1:231833225 T/A cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX 0.43 6.09 0.32 3.2e-9 Alzheimer's disease; CRC cis rs79387448 0.745 rs76720903 chr2:103162826 G/A cg00507830 chr2:103233733 NA 0.51 5.61 0.3 4.25e-8 Gut microbiota (bacterial taxa); CRC cis rs6089584 0.819 rs1467593 chr20:60601432 T/G cg18761221 chr20:60518478 NA -0.53 -8.29 -0.42 2.9e-15 Body mass index; CRC cis rs4268898 0.965 rs13033241 chr2:24476118 G/C cg06627628 chr2:24431161 ITSN2 0.5 7.39 0.38 1.23e-12 Asthma; CRC trans rs66573146 0.572 rs68169399 chr4:6952491 T/A cg07817883 chr1:32538562 TMEM39B 1.13 11.95 0.55 1.43e-27 Granulocyte percentage of myeloid white cells; CRC cis rs6570726 0.935 rs416987 chr6:145847005 G/C cg05347473 chr6:146136440 FBXO30 0.38 6.09 0.32 3.19e-9 Lobe attachment (rater-scored or self-reported); CRC trans rs9291683 0.546 rs7442336 chr4:10045783 G/A cg26043149 chr18:55253948 FECH 0.51 7.63 0.39 2.62e-13 Bone mineral density; CRC cis rs736408 0.608 rs2239547 chr3:52855229 T/C cg15147215 chr3:52552868 STAB1 -0.42 -5.98 -0.31 5.91e-9 Bipolar disorder; CRC cis rs9291683 0.655 rs3822242 chr4:10094904 T/C cg00071950 chr4:10020882 SLC2A9 -0.52 -9.07 -0.45 1.1e-17 Bone mineral density; CRC cis rs2811415 0.597 rs6796874 chr3:127801198 C/T cg13719885 chr3:127795394 NA -0.39 -5.85 -0.31 1.17e-8 Lung function (FEV1/FVC); CRC cis rs72945132 0.598 rs61887432 chr11:70239065 A/C cg00319359 chr11:70116639 PPFIA1 0.55 5.68 0.3 2.93e-8 Coronary artery disease; CRC cis rs612683 0.536 rs1855797 chr1:101027126 A/G cg06223162 chr1:101003688 GPR88 0.36 6.5 0.34 2.9e-10 Breast cancer; CRC cis rs6541297 1.000 rs4846836 chr1:230281316 G/A cg20703242 chr1:230279135 GALNT2 0.52 7.98 0.4 2.49e-14 Coronary artery disease; CRC cis rs651907 0.557 rs62284198 chr3:101474699 G/A cg12386194 chr3:101231763 SENP7 0.48 6.98 0.36 1.59e-11 Colorectal cancer; CRC cis rs561341 1.000 rs2344312 chr17:30243583 G/T cg00745463 chr17:30367425 LRRC37B -0.54 -6.72 -0.35 8.17e-11 Hip circumference adjusted for BMI; CRC cis rs4662945 0.762 rs28510974 chr2:130215288 G/A cg05903289 chr2:130345205 NA -0.31 -6.01 -0.31 5.05e-9 Response to cytidine analogues (gemcitabine); CRC cis rs7914558 1.000 rs10883826 chr10:104830819 A/G cg04362960 chr10:104952993 NT5C2 0.61 9.18 0.45 5.03e-18 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs12900413 0.687 rs12908343 chr15:90319095 C/T cg24249390 chr15:90295951 MESP1 -0.6 -9.49 -0.46 4.94e-19 Coronary artery aneurysm in Kawasaki disease; CRC cis rs123509 0.913 rs123506 chr3:42775976 T/C cg12982090 chr3:42733453 KBTBD5 0.55 7.18 0.37 4.59e-12 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs9787249 0.957 rs41267029 chr1:40214367 A/G cg02773041 chr1:40204384 PPIE 0.64 9.45 0.46 6.35e-19 Blood protein levels; CRC cis rs7607369 0.536 rs11892469 chr2:219669488 A/T cg02176678 chr2:219576539 TTLL4 -0.37 -5.9 -0.31 8.89e-9 Red blood cell count;Amyotrophic lateral sclerosis; CRC cis rs921968 0.541 rs496674 chr2:219432569 G/A cg02176678 chr2:219576539 TTLL4 0.53 8.45 0.42 9.86e-16 Mean corpuscular hemoglobin concentration; CRC cis rs262150 0.788 rs2657408 chr7:158782275 A/G cg12590608 chr7:158785262 NA 0.39 6.84 0.35 3.86e-11 Facial morphology (factor 20); CRC cis rs17818399 0.597 rs12104572 chr2:46862466 C/G cg26688816 chr2:46740690 ATP6V1E2 -0.41 -6.13 -0.32 2.58e-9 Height; CRC cis rs2996428 0.667 rs7538067 chr1:3761772 C/T cg17848003 chr1:3704513 LRRC47 0.4 5.7 0.3 2.66e-8 Red cell distribution width; CRC cis rs7666738 0.791 rs11097601 chr4:98960103 C/T cg05340658 chr4:99064831 C4orf37 0.61 9.57 0.47 2.7e-19 Colonoscopy-negative controls vs population controls; CRC cis rs769267 0.965 rs2017964 chr19:19387149 T/C cg03709012 chr19:19516395 GATAD2A 0.72 10.98 0.52 4.29e-24 Tonsillectomy; CRC trans rs2303319 0.504 rs62189055 chr2:162625749 C/A cg06896663 chr8:82754093 SNX16 -0.69 -6.06 -0.32 3.82e-9 Cognitive function; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg09242721 chr3:3168535 TRNT1 0.36 6.28 0.33 1.1e-9 Liver disease severity in Alagille syndrome; CRC cis rs9325144 0.600 rs6582634 chr12:38748041 G/A cg13010199 chr12:38710504 ALG10B 0.4 5.84 0.31 1.28e-8 Morning vs. evening chronotype; CRC cis rs12200560 0.505 rs211164 chr6:97068140 G/T cg06623918 chr6:96969491 KIAA0776 0.47 6.79 0.35 5.13e-11 Coronary heart disease; CRC cis rs9309711 0.737 rs9284795 chr2:3492065 G/A cg10845886 chr2:3471009 TTC15 -0.68 -10.63 -0.51 7.23e-23 Neurofibrillary tangles; CRC trans rs6693295 0.729 rs6680996 chr1:246214432 C/T cg03680032 chr11:94965610 SESN3 0.49 6.16 0.32 2.13e-9 Migraine - clinic-based;Migraine with aura; CRC cis rs7524258 0.868 rs11120885 chr1:7306755 C/G cg07173049 chr1:7289937 CAMTA1 0.59 9.55 0.47 3.11e-19 Tourette's syndrome or obsessive-compulsive disorder; CRC cis rs9611565 0.802 rs73176694 chr22:41786788 C/T cg06481639 chr22:41940642 POLR3H -0.52 -6.04 -0.32 4.2e-9 Vitiligo; CRC cis rs2120019 0.935 rs34913788 chr15:75372617 A/C cg09165964 chr15:75287851 SCAMP5 -0.8 -12.62 -0.57 4.73e-30 Blood trace element (Zn levels); CRC cis rs1008375 0.898 rs7678654 chr4:17575376 T/G cg02297831 chr4:17616191 MED28 0.47 6.13 0.32 2.53e-9 Parasitemia in Tripanosoma cruzi seropositivity; CRC trans rs1916521 0.519 rs11004952 chr10:57424125 T/C cg16731318 chr1:94313343 NA -0.43 -6.08 -0.32 3.35e-9 Cardiac hypertrophy; CRC cis rs2980439 0.818 rs2945249 chr8:8094726 G/A cg06636001 chr8:8085503 FLJ10661 0.75 12.06 0.55 5.49e-28 Neuroticism; CRC cis rs9894429 0.634 rs11655346 chr17:79572399 A/G cg13777783 chr17:79615861 NA 0.3 5.64 0.3 3.71e-8 Eye color traits; CRC cis rs12541635 0.771 rs12155864 chr8:107105491 C/T cg10147462 chr8:107024639 NA -0.39 -6.05 -0.32 3.92e-9 Age of smoking initiation; CRC cis rs2439831 1.000 rs28628574 chr15:43802038 A/C cg02155558 chr15:43621948 ADAL;LCMT2 0.88 9.36 0.46 1.32e-18 Lung cancer in ever smokers; CRC cis rs10751667 0.714 rs7395879 chr11:963855 G/C cg06064525 chr11:970664 AP2A2 -0.3 -6.11 -0.32 2.78e-9 Alzheimer's disease (late onset); CRC cis rs12762955 0.519 rs7094331 chr10:1022816 T/C cg20503657 chr10:835505 NA -0.42 -6.09 -0.32 3.18e-9 Response to angiotensin II receptor blocker therapy; CRC cis rs3796619 1.000 rs2290409 chr4:1067249 C/T cg27284194 chr4:1044797 NA -0.4 -6.21 -0.32 1.56e-9 Recombination rate (males); CRC cis rs7615952 0.576 rs2276729 chr3:125826214 G/A cg06494592 chr3:125709126 NA -0.5 -6.12 -0.32 2.61e-9 Blood pressure (smoking interaction); CRC cis rs1656402 1.000 rs3021411 chr2:233425224 G/A cg03852847 chr2:233439513 NA 0.45 7.71 0.39 1.54e-13 Non-small cell lung cancer (survival); CRC cis rs6860806 0.531 rs272887 chr5:131665713 A/G cg09877947 chr5:131593287 PDLIM4 0.43 7.04 0.36 1.13e-11 Breast cancer; CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg25441200 chr7:156742235 NOM1 -0.5 -6.18 -0.32 1.89e-9 Diisocyanate-induced asthma; CRC cis rs4862750 0.914 rs9998558 chr4:187874691 A/G cg03452623 chr4:187889614 NA -0.89 -20.28 -0.75 6.76e-60 Lobe attachment (rater-scored or self-reported); CRC cis rs2160860 0.773 rs11786337 chr8:39797764 G/T cg11363097 chr8:39792086 IDO2 -0.43 -7.26 -0.37 2.77e-12 Blood metabolite levels; CRC cis rs12286929 0.839 rs12421648 chr11:115013447 G/A cg04055981 chr11:115044050 NA 0.36 5.85 0.31 1.22e-8 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs4665809 1.000 rs7599132 chr2:26279810 A/T cg25036284 chr2:26402008 FAM59B 0.47 6.22 0.32 1.5e-9 Gut microbiome composition (summer); CRC cis rs875971 1.000 rs1540651 chr7:65650121 C/T cg18912574 chr7:65842487 NCRNA00174 -0.37 -6.42 -0.33 4.63e-10 Aortic root size; CRC cis rs5750830 0.649 rs5757664 chr22:39821536 A/G cg05872129 chr22:39784769 NA -0.6 -11.46 -0.53 7.9e-26 Intelligence (multi-trait analysis); CRC cis rs477895 1.000 rs7947143 chr11:64090422 G/A cg18375707 chr11:64034959 PLCB3 0.48 5.6 0.3 4.49e-8 Mean platelet volume; CRC cis rs6665290 0.935 rs17528667 chr1:227201770 C/T cg10327440 chr1:227177885 CDC42BPA -1.03 -22.54 -0.78 1.1e-68 Myeloid white cell count; CRC cis rs9291683 0.588 rs11732054 chr4:9999877 C/T cg00071950 chr4:10020882 SLC2A9 0.64 11.98 0.55 1.09e-27 Bone mineral density; CRC cis rs3126085 0.935 rs1466757 chr1:152212469 G/A cg09127314 chr1:152161683 NA 0.49 6.29 0.33 1.01e-9 Atopic dermatitis; CRC cis rs2976388 1.000 rs2572910 chr8:143770135 C/G cg15511327 chr8:143859410 LYNX1 -0.33 -5.72 -0.3 2.34e-8 Urinary tract infection frequency; CRC cis rs1862618 0.853 rs252904 chr5:56118733 A/T cg03609598 chr5:56110824 MAP3K1 -0.82 -10.55 -0.5 1.37e-22 Initial pursuit acceleration; CRC cis rs1707322 0.963 rs10789478 chr1:46350506 C/T cg06784218 chr1:46089804 CCDC17 0.6 10.78 0.51 2.04e-23 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs524023 0.958 rs11231825 chr11:64360274 T/C cg06522879 chr11:64358276 SLC22A12 -0.59 -9.36 -0.46 1.31e-18 Urate levels in obese individuals; CRC cis rs8005677 0.962 rs8003934 chr14:23401142 A/G cg01529538 chr14:23388837 RBM23 0.39 6.02 0.32 4.56e-9 Cognitive ability (multi-trait analysis); CRC cis rs6951245 0.938 rs113642700 chr7:1105654 C/T cg03188948 chr7:1209495 NA 0.65 6.85 0.35 3.64e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs77106637 1.000 rs11602858 chr11:72615069 C/G cg03713592 chr11:72463424 ARAP1 0.77 7.1 0.36 7.61e-12 Type 2 diabetes; CRC cis rs1577917 1.000 rs2816821 chr6:86657084 G/A cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.51 -6.89 -0.36 2.82e-11 Response to antipsychotic treatment; CRC cis rs344364 0.518 rs1657129 chr16:1945826 G/A cg03013636 chr16:1946785 NA 0.57 6.99 0.36 1.54e-11 Glomerular filtration rate in chronic kidney disease; CRC cis rs1555322 0.530 rs2275275 chr20:33872311 G/C cg08210727 chr20:33865349 NA 0.43 5.88 0.31 1.03e-8 Attention deficit hyperactivity disorder; CRC cis rs4819052 0.851 rs35064782 chr21:46674360 G/A cg02159808 chr21:46707872 POFUT2;LOC642852 0.53 6.97 0.36 1.74e-11 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs7692995 1.000 rs7698644 chr4:18019572 C/T cg08925142 chr4:18023851 LCORL -0.51 -5.81 -0.3 1.5e-8 Height; CRC cis rs875971 0.862 rs801204 chr7:66022921 T/C cg00343986 chr7:65444356 GUSB -0.44 -6.16 -0.32 2.16e-9 Aortic root size; CRC cis rs853679 0.607 rs200489 chr6:27798257 T/C cg15845792 chr6:28175446 NA 0.73 6.16 0.32 2.13e-9 Depression; CRC cis rs4972806 0.814 rs1446575 chr2:177047801 A/C cg25347419 chr2:177043501 NA 0.58 9.12 0.45 7.55e-18 IgG glycosylation; CRC cis rs4481887 0.927 rs4916087 chr1:248493833 T/C cg00666640 chr1:248458726 OR2T12 0.48 8.08 0.41 1.24e-14 Common traits (Other); CRC cis rs6964587 1.000 rs6942649 chr7:91594510 A/G cg17063962 chr7:91808500 NA 0.67 10.7 0.51 4.01e-23 Breast cancer; CRC cis rs6912958 0.703 rs9353483 chr6:88097180 G/A cg12350822 chr6:88032061 C6orf162;GJB7 0.47 9.39 0.46 1e-18 Monocyte percentage of white cells; CRC cis rs798554 0.679 rs1636249 chr7:2884283 T/G cg19717773 chr7:2847554 GNA12 -0.4 -5.83 -0.31 1.35e-8 Height; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg12315590 chr3:128997497 C3orf37 0.48 6.58 0.34 1.86e-10 Thyroid stimulating hormone; CRC cis rs929354 0.742 rs7806775 chr7:156947199 A/G cg16102536 chr7:156981717 UBE3C 0.4 6.69 0.35 9.57e-11 Body mass index; CRC cis rs11098499 0.618 rs35265692 chr4:120325135 T/C cg09307838 chr4:120376055 NA 0.7 10.23 0.49 1.68e-21 Corneal astigmatism; CRC trans rs561341 0.941 rs736678 chr17:30347423 G/T cg27661571 chr11:113659931 NA -0.89 -10.32 -0.49 8.03e-22 Hip circumference adjusted for BMI; CRC cis rs9311474 0.607 rs4687625 chr3:52563718 C/T cg11645453 chr3:52864694 ITIH4 0.33 5.82 0.31 1.38e-8 Electroencephalogram traits; CRC cis rs933688 1.000 rs2059208 chr5:90732065 A/T cg02339078 chr5:90679543 LOC100129716;ARRDC3 0.87 14.68 0.63 6.92e-38 Smoking behavior; CRC cis rs1008375 1.000 rs2159583 chr4:17658838 T/C cg04450456 chr4:17643702 FAM184B 0.41 6.65 0.34 1.25e-10 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs600231 0.651 rs2846862 chr11:65219790 A/G cg17120908 chr11:65337727 SSSCA1 -0.57 -8.42 -0.42 1.17e-15 Bone mineral density; CRC cis rs3771570 1.000 rs62193197 chr2:242294301 G/A cg21155796 chr2:242212141 HDLBP 0.65 7.01 0.36 1.37e-11 Prostate cancer; CRC cis rs6502050 0.698 rs67143649 chr17:80117772 C/G cg13198984 chr17:80129470 CCDC57 0.46 8.24 0.41 4.11e-15 Life satisfaction; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg25617285 chr1:211431773 RCOR3 0.4 6.23 0.32 1.45e-9 Response to antipsychotic treatment; CRC cis rs35264875 1.000 rs72928636 chr11:68848386 C/T cg03469862 chr11:68924853 NA 0.46 5.91 0.31 8.56e-9 Blond vs. brown hair color; CRC cis rs9549328 0.700 rs3011474 chr13:113617865 T/C cg17524180 chr13:113633600 MCF2L 0.52 9.36 0.46 1.32e-18 Systolic blood pressure; CRC cis rs2032447 0.772 rs199754 chr6:25992309 A/G cg27635394 chr6:26043820 HIST1H2BB 0.45 6.49 0.34 3.25e-10 Intelligence (multi-trait analysis); CRC trans rs7618501 1.000 rs9872864 chr3:49792023 A/G cg21665057 chr3:196295764 WDR53;FBXO45 -0.87 -15.74 -0.66 5.06e-42 Intelligence (multi-trait analysis); CRC cis rs12681288 0.862 rs7814231 chr8:1021103 A/G cg04851639 chr8:1020857 NA -0.37 -7.73 -0.39 1.33e-13 Schizophrenia; CRC cis rs12044355 0.892 rs10429979 chr1:231843569 A/G cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX 0.44 5.95 0.31 6.93e-9 Alzheimer's disease; CRC cis rs2737618 0.674 rs2816973 chr1:200084743 C/G cg21825944 chr1:200113062 NR5A2 0.48 6.95 0.36 1.96e-11 Uric acid levels; CRC trans rs9693857 0.520 rs4557706 chr8:9357369 G/C cg06636001 chr8:8085503 FLJ10661 0.47 6.3 0.33 9.52e-10 Systolic blood pressure; CRC trans rs9858542 0.903 rs9875617 chr3:49634696 G/A cg21582582 chr3:182698605 DCUN1D1 -0.53 -6.49 -0.34 3.11e-10 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs1799949 1.000 rs67060599 chr17:41255102 A/G cg23758822 chr17:41437982 NA 0.81 13.53 0.6 1.85e-33 Menopause (age at onset); CRC cis rs951366 0.789 rs1775154 chr1:205696615 T/A cg07157834 chr1:205819609 PM20D1 0.77 11.67 0.54 1.44e-26 Menarche (age at onset); CRC cis rs883565 0.740 rs6796837 chr3:39076188 C/T cg01426195 chr3:39028469 NA -0.53 -8.53 -0.43 5.57e-16 Handedness; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg17059624 chr11:85358760 TMEM126A 0.48 6.33 0.33 8.01e-10 Thyroid stimulating hormone; CRC cis rs10504229 0.683 rs61201557 chr8:58138370 T/C cg02725872 chr8:58115012 NA -0.64 -11.55 -0.54 3.85e-26 Developmental language disorder (linguistic errors); CRC cis rs7191439 0.722 rs6500491 chr16:88783521 T/C cg02389323 chr16:88786976 FAM38A 0.98 9.0 0.44 1.86e-17 Plateletcrit; CRC cis rs12142240 0.698 rs41534051 chr1:46828734 A/G cg00530320 chr1:46809349 NSUN4 0.56 7.56 0.38 3.93e-13 Menopause (age at onset); CRC cis rs7727544 0.507 rs10051679 chr5:131570931 T/A cg27615366 chr5:131592974 PDLIM4 0.34 6.43 0.33 4.61e-10 Blood metabolite levels; CRC cis rs12024301 0.557 rs74341654 chr1:183642852 C/T cg11505048 chr1:183622726 RGL1;APOBEC4 0.82 6.81 0.35 4.59e-11 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs12477438 0.520 rs1133978 chr2:99741964 C/T cg14399236 chr2:99771627 LIPT1;TSGA10 0.73 12.06 0.55 5.43e-28 Chronic sinus infection; CRC cis rs7177699 0.557 rs7165075 chr15:79115965 G/A cg15571903 chr15:79123663 NA 0.31 6.13 0.32 2.47e-9 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg15773716 chr6:44355950 CDC5L 0.4 6.49 0.34 3.24e-10 Liver disease severity in Alagille syndrome; CRC cis rs832540 0.669 rs173764 chr5:56198920 C/T cg20203395 chr5:56204925 C5orf35 -0.54 -7.43 -0.38 9.48e-13 Coronary artery disease; CRC cis rs1862618 0.627 rs744023 chr5:56197078 C/T cg24531977 chr5:56204891 C5orf35 -1.05 -13.77 -0.6 2.13e-34 Initial pursuit acceleration; CRC cis rs524281 0.861 rs10896080 chr11:65876796 G/A cg14036092 chr11:66035641 RAB1B -0.47 -5.71 -0.3 2.56e-8 Electroencephalogram traits; CRC cis rs853679 0.517 rs9468297 chr6:28118874 G/T cg15845792 chr6:28175446 NA 1.04 13.89 0.61 7.67e-35 Depression; CRC cis rs9291683 0.530 rs13115193 chr4:9982191 C/T cg00071950 chr4:10020882 SLC2A9 0.64 11.84 0.55 3.64e-27 Bone mineral density; CRC cis rs2836974 0.526 rs1888488 chr21:40686521 C/T cg11644478 chr21:40555479 PSMG1 -0.61 -9.22 -0.45 3.58e-18 Cognitive function; CRC cis rs62103177 0.810 rs62103197 chr18:77632923 G/A cg12964065 chr18:77638022 KCNG2 0.68 6.8 0.35 4.94e-11 Opioid sensitivity; CRC cis rs4713118 0.662 rs149901 chr6:27965503 C/T cg20933634 chr6:27740509 NA 0.42 5.85 0.31 1.21e-8 Parkinson's disease; CRC cis rs947211 0.898 rs1772153 chr1:205745782 C/T cg11965913 chr1:205819406 PM20D1 -0.4 -5.65 -0.3 3.47e-8 Parkinson's disease; CRC cis rs1552244 0.515 rs67342818 chr3:10166406 G/A cg02579736 chr3:10068473 FANCD2;CIDECP 1.01 11.58 0.54 2.98e-26 Alzheimer's disease; CRC cis rs7786877 0.723 rs11764045 chr7:100212754 C/T cg20848291 chr7:100343083 ZAN -0.54 -6.69 -0.35 9.44e-11 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs12142240 0.698 rs17357683 chr1:46815378 C/T cg00530320 chr1:46809349 NSUN4 0.57 7.75 0.39 1.19e-13 Menopause (age at onset); CRC cis rs10504229 0.683 rs16921937 chr8:58145010 A/G cg02290350 chr8:58132656 NA -0.56 -7.69 -0.39 1.76e-13 Developmental language disorder (linguistic errors); CRC cis rs728616 0.867 rs76239460 chr10:81723227 C/T cg05935833 chr10:81318306 SFTPA2 -0.73 -8.0 -0.4 2.14e-14 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs600231 0.708 rs682845 chr11:65254201 A/G cg17120908 chr11:65337727 SSSCA1 -0.58 -8.88 -0.44 4.43e-17 Bone mineral density; CRC cis rs28386778 0.897 rs7222189 chr17:61836372 T/C cg06601766 chr17:61851465 DDX42;CCDC47 0.43 5.92 0.31 8.09e-9 Prudent dietary pattern; CRC cis rs7927592 0.956 rs10896341 chr11:68313180 G/A cg01657329 chr11:68192670 LRP5 -0.46 -6.63 -0.34 1.41e-10 Total body bone mineral density; CRC cis rs6696846 0.791 rs7520752 chr1:205054114 C/T cg00857998 chr1:205179979 DSTYK -0.46 -6.27 -0.33 1.11e-9 Red blood cell count; CRC cis rs1506636 1.000 rs12706545 chr7:123348744 C/T cg03229431 chr7:123269106 ASB15 -0.72 -11.75 -0.54 7.37e-27 Plateletcrit;Platelet count; CRC cis rs7666738 0.830 rs28587201 chr4:98991733 C/T cg05340658 chr4:99064831 C4orf37 0.61 9.54 0.47 3.26e-19 Colonoscopy-negative controls vs population controls; CRC cis rs554111 0.637 rs604659 chr1:21043913 T/C cg00373020 chr1:21041521 KIF17 0.36 5.83 0.31 1.3e-8 Facial morphology (factor 17, height of vermillion upper lip); CRC cis rs45509595 0.749 rs401763 chr6:27782528 T/C cg23259851 chr6:27775964 HIST1H2AI;HIST1H2BL 0.71 5.93 0.31 7.74e-9 Breast cancer; CRC cis rs739401 0.527 rs418832 chr11:3072236 C/T cg05729581 chr11:3078854 CARS -0.58 -8.46 -0.42 9.21e-16 Longevity; CRC cis rs798554 0.757 rs960273 chr7:2857876 T/C cg19346786 chr7:2764209 NA -0.43 -7.35 -0.38 1.53e-12 Height; CRC cis rs4713118 0.513 rs149897 chr6:28006650 A/G cg21251018 chr6:28226885 NKAPL 0.48 7.65 0.39 2.18e-13 Parkinson's disease; CRC cis rs1129187 0.967 rs6941212 chr6:42915920 A/G cg02359409 chr6:42947317 PEX6 -0.56 -8.68 -0.43 1.9e-16 Alzheimer's disease in APOE e4+ carriers; CRC cis rs4665630 0.522 rs75866363 chr2:24046426 G/A cg07265300 chr2:24346000 PFN4;LOC375190 0.81 6.34 0.33 7.39e-10 Hypertension; CRC cis rs7224737 1.000 rs2240009 chr17:40283142 C/G cg20291162 chr17:40259547 DHX58 -0.55 -7.98 -0.4 2.46e-14 Fibrinogen levels; CRC cis rs752010 0.631 rs7515066 chr1:42076915 A/G cg06885757 chr1:42089581 HIVEP3 -0.66 -11.19 -0.53 7.53e-25 Lupus nephritis in systemic lupus erythematosus; CRC cis rs7618915 0.501 rs7611731 chr3:52692721 T/C cg11645453 chr3:52864694 ITIH4 0.37 6.6 0.34 1.68e-10 Bipolar disorder; CRC cis rs9296092 0.560 rs9469500 chr6:33526196 C/T cg13560919 chr6:33536144 NA -0.42 -5.69 -0.3 2.78e-8 Age at smoking initiation in chronic obstructive pulmonary disease; CRC cis rs7615952 0.599 rs12485717 chr3:125707075 C/T cg15145296 chr3:125709740 NA 0.54 6.37 0.33 6.49e-10 Blood pressure (smoking interaction); CRC cis rs7605827 0.930 rs11689686 chr2:15527659 C/T cg19274914 chr2:15703543 NA 0.39 5.9 0.31 8.92e-9 Educational attainment (years of education); CRC cis rs909002 0.849 rs1464306 chr1:32076261 T/C cg13919466 chr1:32135498 COL16A1 -0.31 -5.91 -0.31 8.7e-9 Intelligence (multi-trait analysis); CRC cis rs11785400 0.793 rs4581034 chr8:143736968 G/A cg10596483 chr8:143751796 JRK 0.43 5.77 0.3 1.8e-8 Schizophrenia; CRC cis rs35110281 0.591 rs162369 chr21:44931965 G/A cg04455712 chr21:45112962 RRP1B 0.39 7.44 0.38 9.12e-13 Mean corpuscular volume; CRC cis rs9611565 0.512 rs964899 chr22:42142386 G/A cg06634786 chr22:41940651 POLR3H 0.66 7.44 0.38 8.84e-13 Vitiligo; CRC trans rs951252 0.504 rs11734405 chr4:146081096 C/T cg15471812 chr17:38599763 IGFBP4 0.44 6.02 0.31 4.75e-9 Hip circumference; CRC cis rs736408 0.660 rs2019065 chr3:52809525 C/T cg07507251 chr3:52567010 NT5DC2 -0.42 -6.24 -0.33 1.32e-9 Bipolar disorder; CRC cis rs2075371 0.829 rs11770764 chr7:134003308 T/C cg20476274 chr7:133979776 SLC35B4 0.69 11.34 0.53 2.24e-25 Mean platelet volume; CRC cis rs1863824 0.625 rs2018507 chr10:88163251 A/G cg07322936 chr10:88137208 NA 0.63 8.82 0.44 6.67e-17 Schizophrenia; CRC cis rs753778 1.000 rs753778 chr8:142228909 G/A cg23750338 chr8:142222470 SLC45A4 0.4 6.14 0.32 2.33e-9 Reticulocyte fraction of red cells;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; CRC cis rs9372498 0.572 rs10484289 chr6:118827836 T/C cg22561889 chr6:118971681 C6orf204 0.46 5.97 0.31 6.29e-9 Diastolic blood pressure; CRC cis rs2015599 0.549 rs7972032 chr12:29444284 G/A cg09582351 chr12:29534625 ERGIC2 -0.26 -5.71 -0.3 2.47e-8 Mean platelet volume;Platelet count; CRC cis rs4481887 0.708 rs6688853 chr1:248548006 G/A cg26353448 chr1:248524236 OR2T4 -0.32 -6.04 -0.32 4.21e-9 Common traits (Other); CRC cis rs9291683 0.538 rs11727199 chr4:10036190 C/T cg11266682 chr4:10021025 SLC2A9 0.53 11.09 0.52 1.78e-24 Bone mineral density; CRC cis rs11098499 0.754 rs1980025 chr4:120252806 A/G cg24375607 chr4:120327624 NA -0.47 -7.47 -0.38 7.3e-13 Corneal astigmatism; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg06361278 chr17:25783929 NA 0.5 7.84 0.4 6.34e-14 Liver disease severity in Alagille syndrome; CRC cis rs9311474 0.508 rs11720243 chr3:52618018 T/C cg08222913 chr3:52553049 STAB1 -0.34 -6.35 -0.33 7.32e-10 Electroencephalogram traits; CRC cis rs3796352 1.000 rs13076033 chr3:52898427 T/C cg06204229 chr3:52865917 ITIH4 0.54 6.28 0.33 1.07e-9 Immune reponse to smallpox (secreted IL-2); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg07327202 chr20:5107451 CDS2;PCNA 0.41 6.08 0.32 3.29e-9 Response to antipsychotic treatment; CRC cis rs2777491 0.574 rs72739644 chr15:41719706 A/G cg18705301 chr15:41695430 NDUFAF1 -1.13 -19.38 -0.73 2.35e-56 Ulcerative colitis; CRC cis rs1577917 1.000 rs68171315 chr6:86707400 A/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.52 -6.53 -0.34 2.57e-10 Response to antipsychotic treatment; CRC cis rs1552244 0.572 rs59132826 chr3:10169725 G/A cg10729496 chr3:10149963 C3orf24 0.48 5.63 0.3 3.81e-8 Alzheimer's disease; CRC cis rs6570726 0.764 rs4263604 chr6:145916697 A/G cg05347473 chr6:146136440 FBXO30 0.4 5.98 0.31 5.9e-9 Lobe attachment (rater-scored or self-reported); CRC trans rs1814175 0.817 rs28594987 chr11:50045181 C/T cg11707556 chr5:10655725 ANKRD33B -0.42 -8.03 -0.4 1.75e-14 Height; CRC cis rs2243480 1.000 rs1546059 chr7:65654709 C/A cg12463550 chr7:65579703 CRCP -0.73 -6.56 -0.34 2.1e-10 Diabetic kidney disease; CRC cis rs898097 0.544 rs6502022 chr17:80908652 C/T cg10494973 chr17:80897199 TBCD -0.37 -5.67 -0.3 3.11e-8 Breast cancer; CRC cis rs2228479 0.850 rs11639906 chr16:89798183 T/C cg06656553 chr16:89960601 TCF25 -0.68 -5.66 -0.3 3.31e-8 Skin colour saturation; CRC cis rs9372498 0.536 rs72969531 chr6:118729974 C/A cg15382696 chr6:118971807 C6orf204 0.59 7.64 0.39 2.45e-13 Diastolic blood pressure; CRC cis rs7568458 0.846 rs2028900 chr2:85767735 A/G cg02493740 chr2:85810744 VAMP5 0.42 6.7 0.35 9.12e-11 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); CRC cis rs35883536 0.626 rs12135243 chr1:101092955 G/A cg06223162 chr1:101003688 GPR88 -0.34 -5.79 -0.3 1.68e-8 Monocyte count; CRC cis rs7762018 1.000 rs4716380 chr6:170090399 A/G cg24289452 chr6:170231220 NA -0.57 -6.21 -0.32 1.58e-9 Thiazide-induced adverse metabolic effects in hypertensive patients; CRC cis rs9534288 0.797 rs7990095 chr13:46587262 G/C cg15192986 chr13:46630673 CPB2 -0.67 -9.85 -0.48 3.16e-20 Blood protein levels; CRC cis rs67311347 1.000 rs6795475 chr3:40489281 A/G cg24209194 chr3:40518798 ZNF619 0.42 6.36 0.33 6.59e-10 Renal cell carcinoma; CRC cis rs6120849 0.754 rs6120828 chr20:33674460 A/G cg08999081 chr20:33150536 PIGU 0.43 5.89 0.31 9.38e-9 Protein C levels; CRC cis rs4481887 0.893 rs11204632 chr1:248479532 G/A cg00666640 chr1:248458726 OR2T12 0.47 8.01 0.4 1.99e-14 Common traits (Other); CRC cis rs847577 0.651 rs10464490 chr7:97715319 T/G cg24562669 chr7:97807699 LMTK2 0.76 16.49 0.67 5.94e-45 Breast cancer; CRC cis rs1124376 1.000 rs1124376 chr3:20108546 A/G cg05072819 chr3:20081367 KAT2B -0.57 -6.88 -0.35 3.01e-11 Bipolar disorder and schizophrenia; CRC trans rs7395662 1.000 rs12365220 chr11:48555957 T/C cg21153622 chr11:89784906 NA -0.45 -7.23 -0.37 3.31e-12 HDL cholesterol; CRC cis rs7044106 0.734 rs12553070 chr9:123485266 C/T cg09586646 chr9:123605570 PSMD5;LOC253039 0.67 9.86 0.48 2.96e-20 Hip circumference adjusted for BMI; CRC cis rs9900062 0.507 rs7225993 chr17:62708284 C/G cg02598441 chr17:62777298 LOC146880 -0.53 -7.41 -0.38 1.1e-12 QT interval; CRC cis rs7527798 0.571 rs7531923 chr1:207833336 T/G cg21110645 chr1:207815933 NA -0.44 -6.97 -0.36 1.76e-11 Erythrocyte sedimentation rate; CRC cis rs4683142 0.518 rs7653682 chr3:46029271 A/G cg08033130 chr3:45983597 CXCR6;FYCO1 0.42 5.72 0.3 2.46e-8 Methadone dose in opioid dependence; CRC cis rs7224314 1.000 rs57672368 chr17:65358688 G/C cg01507342 chr17:65387096 PITPNC1 -0.46 -6.2 -0.32 1.68e-9 Diisocyanate-induced asthma; CRC cis rs7615952 0.736 rs13063122 chr3:125643860 G/A cg05084668 chr3:125655381 ALG1L -0.63 -9.19 -0.45 4.64e-18 Blood pressure (smoking interaction); CRC cis rs78456975 1.000 rs13422995 chr2:1553554 C/A cg26248373 chr2:1572462 NA -0.65 -7.15 -0.37 5.76e-12 Placebo response in major depressive disorder (% change in symptom score); CRC cis rs7927592 0.913 rs7102898 chr11:68328870 G/A cg16797656 chr11:68205561 LRP5 0.36 5.71 0.3 2.51e-8 Total body bone mineral density; CRC cis rs9486719 0.802 rs2983896 chr6:97029871 G/A cg18709589 chr6:96969512 KIAA0776 -0.45 -5.88 -0.31 9.83e-9 Migraine;Coronary artery disease; CRC cis rs4400599 1.000 rs3001363 chr1:154125067 C/T cg05139571 chr1:154127138 NUP210L -0.42 -6.43 -0.33 4.56e-10 Platelet distribution width; CRC cis rs5750830 0.649 rs5750818 chr22:39820885 A/G cg05872129 chr22:39784769 NA -0.6 -11.46 -0.53 7.9e-26 Intelligence (multi-trait analysis); CRC cis rs875971 0.522 rs1880556 chr7:65432544 T/C cg18876405 chr7:65276391 NA 0.66 12.27 0.56 9.73e-29 Aortic root size; CRC cis rs68170813 0.596 rs76888321 chr7:106945926 T/C cg02696742 chr7:106810147 HBP1 -0.61 -6.92 -0.36 2.43e-11 Coronary artery disease; CRC cis rs1577917 0.876 rs12190735 chr6:86686467 C/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.49 -6.5 -0.34 2.99e-10 Response to antipsychotic treatment; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg06197006 chr17:1359813 CRK 0.44 6.18 0.32 1.93e-9 Response to antipsychotic treatment; CRC cis rs4853012 0.838 rs60705299 chr2:74345370 C/G cg01017244 chr2:74357527 NA 0.68 9.47 0.46 5.71e-19 Gestational age at birth (maternal effect); CRC cis rs1707322 0.752 rs11211169 chr1:46166709 A/G cg06784218 chr1:46089804 CCDC17 0.65 12.15 0.56 2.54e-28 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC trans rs3942852 0.712 rs10742828 chr11:48104555 A/G cg15704280 chr7:45808275 SEPT13 -0.65 -8.28 -0.42 3.04e-15 Acute lymphoblastic leukemia (childhood); CRC cis rs9549367 0.774 rs2287246 chr13:113889127 A/G cg18105134 chr13:113819100 PROZ -0.72 -11.03 -0.52 2.81e-24 Platelet distribution width; CRC cis rs1707322 0.717 rs1135812 chr1:46095272 T/C cg06784218 chr1:46089804 CCDC17 0.65 12.37 0.56 4.08e-29 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs4862750 0.914 rs6837117 chr4:187872379 C/T cg10295955 chr4:187884368 NA -1.0 -22.68 -0.78 3.05e-69 Lobe attachment (rater-scored or self-reported); CRC cis rs651907 0.535 rs35799195 chr3:101521927 A/G cg12386194 chr3:101231763 SENP7 0.52 7.45 0.38 8.46e-13 Colorectal cancer; CRC cis rs10876993 0.784 rs7314152 chr12:58017701 T/G cg15848620 chr12:58087721 OS9 0.57 7.69 0.39 1.74e-13 Celiac disease or Rheumatoid arthritis; CRC cis rs61774743 0.557 rs4359027 chr1:41848296 G/A cg24596898 chr1:41849189 NA 0.35 5.77 0.3 1.83e-8 Intelligence (multi-trait analysis); CRC cis rs9486715 0.867 rs11152924 chr6:96877383 A/G cg06623918 chr6:96969491 KIAA0776 1.02 20.3 0.75 5.5e-60 Headache; CRC cis rs8180040 0.764 rs4683324 chr3:47251284 T/C cg02527881 chr3:46936655 PTH1R -0.36 -6.68 -0.35 1.04e-10 Colorectal cancer; CRC cis rs868036 1.000 rs884202 chr15:68054388 G/A cg05925327 chr15:68127851 NA 0.29 5.65 0.3 3.53e-8 Restless legs syndrome; CRC cis rs519973 1.000 rs2378351 chr3:187635979 A/G cg10168494 chr3:187635183 NA 0.51 8.94 0.44 2.95e-17 Allergic disease (asthma, hay fever or eczema); CRC cis rs11958404 0.932 rs56065211 chr5:157439386 C/T cg05962755 chr5:157440814 NA 1.01 12.88 0.58 5.12e-31 IgG glycosylation; CRC cis rs9584850 0.574 rs60492361 chr13:99172653 T/C cg20487152 chr13:99095054 FARP1 0.43 5.69 0.3 2.75e-8 Neuroticism; CRC cis rs11764590 0.715 rs11760737 chr7:2104055 T/C cg25834613 chr7:1915315 MAD1L1 -0.41 -5.72 -0.3 2.36e-8 Neuroticism; CRC cis rs6969780 1.000 rs1801085 chr7:27168590 A/G cg26364809 chr7:27145159 NA -0.73 -6.78 -0.35 5.46e-11 Diastolic blood pressure;Blood pressure traits (multi-trait analysis);Systolic blood pressure;Hypertension; CRC cis rs2404602 0.622 rs4886506 chr15:77207277 G/T cg23625390 chr15:77176239 SCAPER 0.86 14.07 0.61 1.65e-35 Blood metabolite levels; CRC cis rs6540559 0.546 rs75308488 chr1:210030639 T/C cg22029157 chr1:209979665 IRF6 0.61 6.79 0.35 5.21e-11 Cleft lip with or without cleft palate; CRC cis rs394563 0.726 rs6942381 chr6:149662991 G/C cg11245181 chr6:149772854 ZC3H12D 0.53 9.34 0.46 1.46e-18 Dupuytren's disease; CRC cis rs4332037 0.664 rs73046334 chr7:1887037 T/C cg25834613 chr7:1915315 MAD1L1 -0.41 -6.32 -0.33 8.43e-10 Bipolar disorder; CRC cis rs9311474 0.596 rs524986 chr3:52228496 T/C cg08222913 chr3:52553049 STAB1 -0.32 -6.16 -0.32 2.1e-9 Electroencephalogram traits; CRC cis rs780096 0.506 rs1262430 chr2:27673798 T/C cg22903471 chr2:27725779 GCKR -0.37 -5.96 -0.31 6.44e-9 Total body bone mineral density; CRC cis rs72781680 0.560 rs72781698 chr2:24271506 C/T cg20701182 chr2:24300061 SF3B14 0.63 7.06 0.36 1.02e-11 Lymphocyte counts; CRC cis rs883565 0.569 rs784513 chr3:39164915 G/A cg01426195 chr3:39028469 NA 0.42 6.99 0.36 1.56e-11 Handedness; CRC trans rs9858542 0.953 rs6766131 chr3:49538932 T/C cg21659725 chr3:3221576 CRBN -0.68 -9.33 -0.46 1.64e-18 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs2179367 0.959 rs536203 chr6:149651264 G/A cg11245181 chr6:149772854 ZC3H12D -0.4 -6.03 -0.32 4.4e-9 Dupuytren's disease; CRC cis rs72772090 0.539 rs11748328 chr5:96169916 T/G cg17330273 chr5:96107758 CAST;ERAP1 -0.65 -6.38 -0.33 6.17e-10 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs853679 0.517 rs1904840 chr6:28108232 C/T cg12273811 chr6:28175739 NA 0.73 9.16 0.45 5.8e-18 Depression; CRC cis rs8072100 0.676 rs9908049 chr17:45502096 G/C cg25173405 chr17:45401733 C17orf57 -0.42 -6.19 -0.32 1.75e-9 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs1953600 0.870 rs2236557 chr10:81923961 A/G cg04850286 chr10:81895943 PLAC9 0.36 6.3 0.33 9.47e-10 Sarcoidosis; CRC cis rs7918232 0.941 rs1753415 chr10:27395102 T/C cg14442939 chr10:27389572 ANKRD26 0.82 8.98 0.44 2.19e-17 Breast cancer; CRC cis rs11098499 0.866 rs6847778 chr4:120293582 A/G cg24375607 chr4:120327624 NA 0.49 7.58 0.39 3.63e-13 Corneal astigmatism; CRC cis rs909674 0.541 rs5750816 chr22:39810379 A/G cg25956985 chr22:39795188 MAP3K7IP1 0.47 7.02 0.36 1.28e-11 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; CRC trans rs916888 0.647 rs199524 chr17:44848438 G/T cg22968622 chr17:43663579 NA -0.8 -10.52 -0.5 1.6400000000000001e-22 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs35883536 1.000 rs3861733 chr1:101111807 G/A cg14515779 chr1:101123966 NA -0.43 -8.29 -0.42 2.9e-15 Monocyte count; CRC cis rs4713118 0.955 rs9393848 chr6:27688369 C/T cg02683197 chr6:28174875 NA 0.6 7.89 0.4 4.56e-14 Parkinson's disease; CRC cis rs294883 0.858 rs9365037 chr6:159704003 C/A cg14500486 chr6:159655392 FNDC1 -0.35 -5.75 -0.3 2.09e-8 Coronary artery disease; CRC trans rs9388451 0.839 rs3966775 chr6:126067655 C/A cg05039488 chr6:79577232 IRAK1BP1 -0.59 -9.03 -0.45 1.43e-17 Brugada syndrome; CRC cis rs3736594 0.559 rs62141292 chr2:27784300 A/C cg27432699 chr2:27873401 GPN1 0.65 8.54 0.43 5.09e-16 Fasting blood glucose;Fasting blood glucose (BMI interaction); CRC cis rs13253111 1.000 rs62500888 chr8:28061823 A/G cg26534493 chr8:28060551 NA 0.48 8.48 0.42 7.61e-16 Childhood body mass index; CRC cis rs10504229 1.000 rs57261109 chr8:58172152 C/T cg24829409 chr8:58192753 C8orf71 -0.68 -11.34 -0.53 2.27e-25 Developmental language disorder (linguistic errors); CRC trans rs116095464 0.558 rs6555058 chr5:226376 C/T cg00938859 chr5:1591904 SDHAP3 -0.62 -6.72 -0.35 8.19e-11 Breast cancer; CRC cis rs9311474 0.508 rs11720243 chr3:52618018 T/C cg18404041 chr3:52824283 ITIH1 -0.41 -8.56 -0.43 4.5e-16 Electroencephalogram traits; CRC cis rs6662572 0.723 rs72677543 chr1:46565329 A/T cg08644498 chr1:46502608 NA 0.46 7.28 0.37 2.42e-12 Blood protein levels; CRC cis rs1129187 0.837 rs3763236 chr6:42902508 C/T cg21280719 chr6:42927975 GNMT 0.41 9.04 0.45 1.35e-17 Alzheimer's disease in APOE e4+ carriers; CRC cis rs476633 0.691 rs11858115 chr15:41542591 G/A cg18705301 chr15:41695430 NDUFAF1 -0.41 -6.85 -0.35 3.54e-11 Glomerular filtration rate (creatinine); CRC trans rs2303319 0.504 rs56009150 chr2:162598582 T/C cg27342122 chr8:133787442 PHF20L1 -0.71 -6.02 -0.31 4.6e-9 Cognitive function; CRC cis rs7538876 0.903 rs1324367 chr1:17752451 C/G cg01904812 chr1:17746340 RCC2 0.38 6.23 0.32 1.41e-9 Basal cell carcinoma; CRC cis rs12477438 0.765 rs6542846 chr2:99563654 T/C cg14399236 chr2:99771627 LIPT1;TSGA10 -0.6 -8.25 -0.41 3.89e-15 Chronic sinus infection; CRC cis rs4638749 0.677 rs4676187 chr2:108842936 T/C cg25838818 chr2:108905173 SULT1C2 -0.33 -5.61 -0.3 4.35e-8 Blood pressure; CRC cis rs7680126 0.500 rs4640669 chr4:10145733 A/G cg00071950 chr4:10020882 SLC2A9 0.47 6.19 0.32 1.74e-9 Urate levels in lean individuals;Urate levels in overweight individuals;Urate levels in obese individuals; CRC cis rs7107174 1.000 rs10899467 chr11:78014057 G/T cg02023728 chr11:77925099 USP35 0.55 7.68 0.39 1.83e-13 Testicular germ cell tumor; CRC cis rs9322817 0.691 rs2400071 chr6:105344075 C/T cg02098413 chr6:105308735 HACE1 0.46 9.14 0.45 6.64e-18 Thyroid stimulating hormone; CRC cis rs1434579 0.966 rs1062093 chr19:44931995 C/G cg15540054 chr19:45004280 ZNF180 0.5 6.36 0.33 6.63e-10 Tuberculosis; CRC cis rs2549003 1.000 rs9282763 chr5:131822133 T/C cg02551604 chr5:131831745 NA -0.54 -8.34 -0.42 2e-15 Asthma (sex interaction); CRC cis rs34526934 0.608 rs7591820 chr2:177028144 G/T cg25347419 chr2:177043501 NA -0.48 -6.43 -0.33 4.54e-10 Obstructive sleep apnea trait (apnea hypopnea index); CRC cis rs9902453 0.765 rs2729447 chr17:28099002 T/C cg26525008 chr17:28256777 EFCAB5;SSH2 -0.72 -12.11 -0.56 3.76e-28 Coffee consumption (cups per day); CRC cis rs7584330 0.868 rs6760842 chr2:238398165 C/T cg14458575 chr2:238380390 NA -0.68 -11.79 -0.54 5.45e-27 Prostate cancer; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg08502759 chr11:10562853 RNF141 0.43 7.11 0.36 7.2e-12 Liver disease severity in Alagille syndrome; CRC cis rs7727544 0.709 rs272852 chr5:131688767 G/A cg07395648 chr5:131743802 NA -0.4 -6.23 -0.32 1.46e-9 Blood metabolite levels; CRC cis rs28386778 0.830 rs2584625 chr17:61903445 G/C cg06873352 chr17:61820015 STRADA 0.8 15.25 0.64 4.21e-40 Prudent dietary pattern; CRC cis rs7927771 1.000 rs4752873 chr11:47857520 C/T cg05585544 chr11:47624801 NA -0.61 -10.81 -0.51 1.66e-23 Subjective well-being; CRC cis rs919433 0.713 rs6719729 chr2:198480072 G/A cg10820045 chr2:198174542 NA 0.43 7.48 0.38 6.87e-13 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC cis rs1552244 1.000 rs17032276 chr3:10076975 A/C cg02579736 chr3:10068473 FANCD2;CIDECP 1.05 14.06 0.61 1.71e-35 Alzheimer's disease; CRC cis rs412000 0.553 rs2680702 chr17:56431549 A/G cg12560992 chr17:57184187 TRIM37 0.43 6.05 0.32 3.91e-9 Primary tooth development (time to first tooth eruption); CRC cis rs11971779 0.584 rs34762928 chr7:139113168 T/A cg23387468 chr7:139079360 LUC7L2 0.41 7.04 0.36 1.14e-11 Diisocyanate-induced asthma; CRC cis rs2549003 1.000 rs3846732 chr5:131816087 T/C cg02551604 chr5:131831745 NA -0.54 -8.38 -0.42 1.58e-15 Asthma (sex interaction); CRC cis rs4363385 0.818 rs1334850 chr1:153004519 G/T cg25856811 chr1:152973957 SPRR3 -0.25 -6.94 -0.36 2.12e-11 Inflammatory skin disease; CRC cis rs1552244 0.935 rs11926481 chr3:10142102 G/T cg18598329 chr3:10140678 FANCD2;C3orf24 -0.89 -12.81 -0.58 9.35e-31 Alzheimer's disease; CRC cis rs11239930 1.000 rs11239930 chr1:146560564 C/T cg11655389 chr1:146548469 NA -0.32 -5.76 -0.3 1.93e-8 AIDS progression; CRC cis rs6964587 0.900 rs62467794 chr7:91850578 C/T cg17063962 chr7:91808500 NA 0.78 11.13 0.52 1.28e-24 Breast cancer; CRC cis rs875971 1.000 rs6460295 chr7:65882728 T/C cg11764359 chr7:65958608 NA 0.61 9.95 0.48 1.41e-20 Aortic root size; CRC cis rs3741404 0.584 rs645461 chr11:63893694 C/T cg19465662 chr11:63993652 NUDT22;TRPT1 -0.75 -12.05 -0.55 6.24e-28 Platelet count; CRC cis rs1005277 0.602 rs1831315 chr10:38473353 T/C cg25517755 chr10:38738941 LOC399744 -0.43 -6.11 -0.32 2.88e-9 Extrinsic epigenetic age acceleration; CRC cis rs67478160 0.643 rs3818085 chr14:104215985 C/T cg08213375 chr14:104286397 PPP1R13B 0.65 13.79 0.61 1.92e-34 Schizophrenia; CRC cis rs7617773 0.563 rs62263035 chr3:48391569 C/T cg11946769 chr3:48343235 NME6 0.61 8.28 0.42 3.08e-15 Coronary artery disease; CRC cis rs12549902 0.932 rs6981607 chr8:41508168 A/C cg17182837 chr8:41585554 ANK1 -0.38 -5.99 -0.31 5.65e-9 Corrected insulin response;Corrected insulin response adjusted for insulin sensitivity index;Insulin levels adjusted for BMI;Type 2 diabetes; CRC cis rs2404602 0.735 rs2957614 chr15:76696635 C/T cg03037974 chr15:76606532 NA 0.53 8.12 0.41 9.26e-15 Blood metabolite levels; CRC cis rs3733585 0.673 rs7376948 chr4:9954708 G/A cg11266682 chr4:10021025 SLC2A9 -0.47 -9.48 -0.46 5.41e-19 Cleft plate (environmental tobacco smoke interaction); CRC cis rs9435341 1.000 rs1762484 chr1:107613923 A/C cg14671364 chr1:107599128 PRMT6 -0.57 -7.78 -0.39 9.76e-14 Facial morphology (factor 21, depth of nasal alae); CRC cis rs6570726 0.935 rs367612 chr6:145828987 A/G cg05347473 chr6:146136440 FBXO30 0.39 6.06 0.32 3.69e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs10504229 0.815 rs72650877 chr8:58164510 T/C cg21724239 chr8:58056113 NA 0.65 8.48 0.42 7.95e-16 Developmental language disorder (linguistic errors); CRC cis rs951366 0.617 rs708727 chr1:205767885 G/A cg17178900 chr1:205818956 PM20D1 0.84 13.5 0.6 2.35e-33 Menarche (age at onset); CRC cis rs4332037 0.851 rs1403175 chr7:1964357 A/T cg23422044 chr7:1970798 MAD1L1 0.6 7.72 0.39 1.42e-13 Bipolar disorder; CRC cis rs10779751 1.000 rs6679878 chr1:11306882 A/G cg08854313 chr1:11322531 MTOR 0.67 9.41 0.46 8.59e-19 Body mass index; CRC cis rs72730918 0.564 rs28408214 chr15:51867574 A/T cg14296394 chr15:51910925 DMXL2 -0.45 -5.95 -0.31 6.86e-9 Intelligence (multi-trait analysis); CRC cis rs10779751 0.960 rs6661859 chr1:11301063 T/C cg08854313 chr1:11322531 MTOR 0.7 10.0 0.48 9.84e-21 Body mass index; CRC cis rs9399137 0.507 rs12663810 chr6:135289782 G/C cg24558204 chr6:135376177 HBS1L 0.59 8.71 0.43 1.52e-16 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; CRC cis rs736408 0.609 rs13082960 chr3:52785168 A/C cg07507251 chr3:52567010 NT5DC2 0.41 5.84 0.31 1.27e-8 Bipolar disorder; CRC cis rs6988636 1.000 rs13261066 chr8:124190276 G/A cg27053337 chr8:124217698 FAM83A 0.43 6.59 0.34 1.74e-10 Urinary uromodulin levels; CRC cis rs7811142 1.000 rs1000215 chr7:100004543 A/G cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.76 11.03 0.52 2.86e-24 Platelet count; CRC cis rs4332037 0.754 rs62436669 chr7:1926636 G/A cg24505167 chr7:1915268 MAD1L1 -0.44 -6.2 -0.32 1.72e-9 Bipolar disorder; CRC cis rs2153535 0.580 rs9328479 chr6:8519646 A/G cg07606381 chr6:8435919 SLC35B3 0.67 10.87 0.51 9.87e-24 Motion sickness; CRC cis rs929354 0.742 rs7807556 chr7:156934329 T/C cg16102536 chr7:156981717 UBE3C 0.41 6.79 0.35 5.35e-11 Body mass index; CRC cis rs9527 0.662 rs743575 chr10:104594906 T/G cg15744005 chr10:104629667 AS3MT -0.35 -6.42 -0.33 4.67e-10 Arsenic metabolism; CRC cis rs9462846 0.959 rs57514728 chr6:42860748 C/T cg02353165 chr6:42928485 GNMT 0.54 6.91 0.36 2.57e-11 Blood protein levels; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg23784313 chr12:15942613 EPS8 0.45 6.05 0.32 4.01e-9 Thyroid stimulating hormone; CRC cis rs2576037 0.796 rs2571032 chr18:44578250 T/A cg19077165 chr18:44547161 KATNAL2 0.43 6.71 0.35 8.7e-11 Personality dimensions; CRC cis rs4731207 0.698 rs10261610 chr7:124450577 G/A cg23710748 chr7:124431027 NA 0.38 6.03 0.32 4.49e-9 Cutaneous malignant melanoma; CRC cis rs6951245 0.554 rs75075857 chr7:1140298 C/T cg04025307 chr7:1156635 C7orf50 0.67 8.42 0.42 1.15e-15 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs8062405 0.755 rs4788073 chr16:28594549 A/G cg05139728 chr16:28306816 SBK1 -0.38 -6.23 -0.32 1.41e-9 Cognitive ability (multi-trait analysis);Cognitive ability; CRC cis rs2249625 0.545 rs2463746 chr6:72876954 C/G cg18830697 chr6:72922368 RIMS1 -0.39 -7.92 -0.4 3.81e-14 Acute urticaria and angioedema (non-steroidal anti-inflammatory drug-induced); CRC cis rs3806843 0.576 rs246037 chr5:140331846 C/T cg19875535 chr5:140030758 IK 0.4 6.12 0.32 2.64e-9 Depressive symptoms (multi-trait analysis); CRC cis rs10504229 0.639 rs66667899 chr8:58117065 C/T cg02725872 chr8:58115012 NA -0.64 -11.55 -0.54 3.85e-26 Developmental language disorder (linguistic errors); CRC cis rs10504229 0.906 rs7003276 chr8:58173089 A/T cg02725872 chr8:58115012 NA -0.39 -6.78 -0.35 5.63e-11 Developmental language disorder (linguistic errors); CRC cis rs231513 0.954 rs231493 chr17:41976998 G/C cg26893861 chr17:41843967 DUSP3 -0.62 -6.27 -0.33 1.11e-9 Cognitive function; CRC cis rs941408 0.515 rs2110118 chr19:2775144 T/C cg06609049 chr19:2785107 THOP1 0.98 16.66 0.68 1.26e-45 Total cholesterol levels; CRC cis rs1580019 0.568 rs2122633 chr7:32523870 G/T cg14728415 chr7:32535168 LSM5;AVL9 0.45 6.32 0.33 8.62e-10 Cognitive ability; CRC cis rs6570726 0.935 rs1883406 chr6:145823205 A/G cg05347473 chr6:146136440 FBXO30 0.37 6.0 0.31 5.27e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs4819052 0.808 rs2838825 chr21:46655651 C/T cg11663144 chr21:46675770 NA -0.78 -12.26 -0.56 9.94e-29 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs514406 0.698 rs511599 chr1:53362818 T/C cg24675658 chr1:53192096 ZYG11B -0.68 -9.85 -0.48 3.17e-20 Monocyte count; CRC cis rs765787 0.530 rs2554455 chr15:45521304 T/C cg24006582 chr15:45444508 DUOX1 -0.56 -8.35 -0.42 1.86e-15 Uric acid levels; CRC cis rs9584850 0.789 rs7988345 chr13:99117685 A/G cg07423050 chr13:99094983 FARP1 0.44 6.08 0.32 3.39e-9 Neuroticism; CRC cis rs1707322 0.717 rs1547925 chr1:46085356 C/T cg03146154 chr1:46216737 IPP -0.66 -9.3 -0.46 1.95e-18 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs10927875 0.541 rs1739842 chr1:16342848 T/G cg22431228 chr1:16359049 CLCNKA -0.38 -6.91 -0.36 2.52e-11 Dilated cardiomyopathy; CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg22233523 chr18:44497604 PIAS2 0.41 6.82 0.35 4.3e-11 Obesity-related traits; CRC cis rs834811 0.563 rs834801 chr7:135871355 A/G cg01726295 chr7:135938950 NA 0.38 6.5 0.34 2.92e-10 Post-traumatic stress disorder; CRC cis rs67311347 1.000 rs4973994 chr3:40453024 T/C cg24209194 chr3:40518798 ZNF619 0.41 5.88 0.31 1.01e-8 Renal cell carcinoma; CRC trans rs1908814 0.516 rs60176945 chr8:11796674 T/C cg06636001 chr8:8085503 FLJ10661 0.47 6.95 0.36 2.01e-11 Neuroticism; CRC cis rs12926788 0.542 rs6497759 chr16:24801737 G/A cg04756594 chr16:24857601 SLC5A11 0.33 6.7 0.35 8.99e-11 Ejection fraction in Tripanosoma cruzi seropositivity; CRC cis rs1005277 0.579 rs2505257 chr10:38372664 A/G cg25517755 chr10:38738941 LOC399744 -0.44 -6.42 -0.33 4.63e-10 Extrinsic epigenetic age acceleration; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg04732357 chr2:96658324 NA 0.44 6.61 0.34 1.56e-10 Intelligence (multi-trait analysis); CRC cis rs736408 0.522 rs11716747 chr3:52748857 C/T cg18404041 chr3:52824283 ITIH1 -0.4 -8.28 -0.42 3.21e-15 Bipolar disorder; CRC cis rs55665837 1.000 rs10766182 chr11:14499536 A/G cg19336497 chr11:14380999 RRAS2 -0.4 -6.68 -0.35 1.03e-10 Vitamin D levels; CRC cis rs11628318 0.614 rs7155804 chr14:103114945 A/G cg12046867 chr14:103022105 NA 0.77 8.98 0.44 2.14e-17 Platelet count; CRC cis rs7927771 0.864 rs7937331 chr11:47430458 T/C cg20307385 chr11:47447363 PSMC3 0.6 8.99 0.44 2.05e-17 Subjective well-being; CRC cis rs10256972 0.504 rs2949178 chr7:1209925 T/C cg23708337 chr7:1209742 NA 0.51 7.9 0.4 4.34e-14 Longevity;Endometriosis; CRC cis rs9903692 0.954 rs7212202 chr17:46132723 G/C cg21215337 chr17:46176117 CBX1 0.43 7.83 0.4 6.68e-14 Pulse pressure; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg05353131 chr15:64995641 OAZ2 0.46 6.88 0.35 3.11e-11 Intelligence (multi-trait analysis); CRC cis rs73206853 0.841 rs111612251 chr12:111017607 T/C cg12870014 chr12:110450643 ANKRD13A 0.8 9.34 0.46 1.47e-18 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC cis rs7605827 0.897 rs13022830 chr2:15696542 T/C cg19274914 chr2:15703543 NA 0.37 5.62 0.3 4.13e-8 Educational attainment (years of education); CRC cis rs6502050 0.764 rs28676462 chr17:80105100 G/C cg02741985 chr17:80059408 CCDC57 0.43 7.15 0.37 5.66e-12 Life satisfaction; CRC cis rs7937682 0.855 rs7109592 chr11:111533105 C/A cg09085632 chr11:111637200 PPP2R1B -1.0 -20.52 -0.75 7.88e-61 Primary sclerosing cholangitis; CRC cis rs7769051 0.522 rs7738256 chr6:133113066 C/G cg22852734 chr6:133119734 C6orf192 1.07 9.58 0.47 2.5e-19 Type 2 diabetes nephropathy; CRC cis rs2456568 0.741 rs10831137 chr11:93636912 C/T cg26875233 chr11:93583750 C11orf90 -0.31 -6.0 -0.31 5.08e-9 Response to serotonin reuptake inhibitors in major depressive disorder; CRC cis rs7647973 0.961 rs7626076 chr3:49298139 G/A cg20833759 chr3:49053208 WDR6;DALRD3 0.54 7.97 0.4 2.67e-14 Menarche (age at onset); CRC cis rs12230513 0.793 rs1896045 chr12:55953568 A/G cg19537932 chr12:55886519 OR6C68 -0.42 -5.65 -0.3 3.56e-8 Contrast sensitivity; CRC cis rs3806843 1.000 rs3756339 chr5:140180537 A/G cg19875535 chr5:140030758 IK 0.6 9.85 0.48 3.25e-20 Depressive symptoms (multi-trait analysis); CRC cis rs11098499 0.618 rs28491261 chr4:120294900 C/A cg24375607 chr4:120327624 NA 0.5 7.74 0.39 1.26e-13 Corneal astigmatism; CRC trans rs7395662 0.963 rs11039773 chr11:48513931 A/G cg21153622 chr11:89784906 NA -0.45 -7.24 -0.37 3.11e-12 HDL cholesterol; CRC cis rs796364 0.951 rs281793 chr2:200847990 G/A cg25936922 chr2:200820526 C2orf60;C2orf47 0.73 7.97 0.4 2.71e-14 Schizophrenia; CRC cis rs7119 0.635 rs2667767 chr15:77876031 T/C cg27398640 chr15:77910606 LINGO1 0.46 8.16 0.41 6.94e-15 Type 2 diabetes; CRC cis rs798554 0.642 rs2533871 chr7:2883006 C/G cg13628971 chr7:2884303 GNA12 0.62 8.48 0.42 7.59e-16 Height; CRC cis rs7811142 0.945 rs6955362 chr7:100056166 C/T cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.19 17.58 0.7 2.92e-49 Platelet count; CRC cis rs2836974 0.897 rs13052882 chr21:40555351 G/C cg17971929 chr21:40555470 PSMG1 0.86 13.14 0.59 5.44e-32 Cognitive function; CRC cis rs13118159 0.509 rs4974554 chr4:1356967 A/C cg16405210 chr4:1374714 KIAA1530 -0.91 -14.31 -0.62 1.87e-36 Longevity; CRC cis rs6502050 0.835 rs8065981 chr17:80091393 G/T cg25804541 chr17:80189381 SLC16A3 -0.3 -5.74 -0.3 2.19e-8 Life satisfaction; CRC cis rs7829975 0.688 rs7817376 chr8:8380530 C/T cg06636001 chr8:8085503 FLJ10661 -0.53 -8.12 -0.41 9.55e-15 Mood instability; CRC cis rs2549003 0.870 rs10053046 chr5:131821558 A/G cg21138405 chr5:131827807 IRF1 0.57 11.38 0.53 1.59e-25 Asthma (sex interaction); CRC cis rs34311866 0.656 rs11731377 chr4:971266 T/G cg07828340 chr4:882639 GAK 0.75 7.18 0.37 4.81e-12 Parkinson's disease; CRC cis rs2294693 0.947 rs736793 chr6:40997919 A/T cg14769373 chr6:40998127 UNC5CL -0.56 -7.46 -0.38 7.65e-13 Gastric cancer;Non-cardia gastric cancer; CRC cis rs1190552 0.894 rs4906203 chr14:102928991 C/T cg18135206 chr14:102964638 TECPR2 0.49 5.93 0.31 7.6e-9 Blood protein levels; CRC trans rs1814175 0.645 rs28839231 chr11:50044292 G/T cg03929089 chr4:120376271 NA -0.89 -15.95 -0.66 7.68e-43 Height; CRC cis rs6840360 0.615 rs6535822 chr4:152679722 A/G cg09659197 chr4:152720779 NA 0.42 8.83 0.44 6.15e-17 Intelligence (multi-trait analysis); CRC cis rs6479527 0.806 rs7867253 chr9:96750794 C/T cg14459158 chr9:96720562 NA 0.41 7.52 0.38 5.11e-13 Esophageal adenocarcinoma; CRC cis rs28386778 0.863 rs3826341 chr17:61819222 C/A cg06601766 chr17:61851465 DDX42;CCDC47 0.43 5.85 0.31 1.21e-8 Prudent dietary pattern; CRC cis rs13315871 0.860 rs17059098 chr3:58255739 G/A cg20936604 chr3:58311152 NA -0.75 -6.89 -0.35 2.9100000000000002e-11 Cholesterol, total; CRC cis rs7727544 0.901 rs55633655 chr5:131598756 T/G cg04518342 chr5:131593106 PDLIM4 0.36 6.72 0.35 7.83e-11 Blood metabolite levels; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg14349843 chr17:16284098 UBB 0.46 6.45 0.34 4.04e-10 Response to antipsychotic treatment; CRC cis rs1552244 1.000 rs17032396 chr3:10153559 A/G cg16606324 chr3:10149918 C3orf24 -0.7 -9.26 -0.45 2.68e-18 Alzheimer's disease; CRC cis rs12477438 0.834 rs1563108 chr2:99701153 A/G cg26064155 chr2:99771622 LIPT1;TSGA10 -0.62 -8.57 -0.43 4.12e-16 Chronic sinus infection; CRC cis rs7113874 0.544 rs9704807 chr11:8578771 G/C cg17679104 chr11:8615758 STK33 -0.35 -5.9 -0.31 8.88e-9 Body mass index in physically active individuals;Body mass index (joint analysis main effects and physical activity interaction); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg04402633 chr11:2907113 CDKN1C 0.37 6.01 0.31 4.91e-9 Liver disease severity in Alagille syndrome; CRC cis rs10751667 0.600 rs10751672 chr11:948712 T/C ch.11.42038R chr11:967971 AP2A2 0.59 10.18 0.49 2.44e-21 Alzheimer's disease (late onset); CRC cis rs875971 1.000 rs11974219 chr7:65647410 C/T cg00343986 chr7:65444356 GUSB -0.45 -6.72 -0.35 8.25e-11 Aortic root size; CRC cis rs2797160 0.935 rs12717178 chr6:126016499 G/A cg05901451 chr6:126070800 HEY2 0.4 6.16 0.32 2.15e-9 Endometrial cancer; CRC cis rs311392 0.833 rs6473917 chr8:55090430 A/G cg20636351 chr8:55087400 NA -0.33 -5.86 -0.31 1.1e-8 Pelvic organ prolapse (moderate/severe); CRC cis rs754466 0.606 rs11002310 chr10:79596030 A/C cg17075019 chr10:79541650 NA -0.98 -18.35 -0.71 2.72e-52 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs73200209 0.744 rs1865787 chr12:116429689 A/G cg01776926 chr12:116560359 MED13L -0.66 -7.66 -0.39 2.11e-13 Total body bone mineral density; CRC cis rs4713118 0.621 rs4713132 chr6:28034035 A/G cg02683197 chr6:28174875 NA 0.72 8.85 0.44 5.44e-17 Parkinson's disease; CRC cis rs75920871 0.502 rs7124996 chr11:116928006 C/T cg01368799 chr11:117014884 PAFAH1B2 -0.4 -5.76 -0.3 1.93e-8 Subjective well-being; CRC cis rs9443645 0.527 rs10943588 chr6:79510994 A/C cg05283184 chr6:79620031 NA -0.44 -6.31 -0.33 8.9e-10 Intelligence (multi-trait analysis); CRC cis rs4363385 0.510 rs7531076 chr1:153039167 G/T cg25856811 chr1:152973957 SPRR3 -0.21 -5.69 -0.3 2.87e-8 Inflammatory skin disease; CRC cis rs1552244 1.000 rs61052895 chr3:10147516 G/A cg16606324 chr3:10149918 C3orf24 0.72 9.59 0.47 2.2e-19 Alzheimer's disease; CRC cis rs9858542 0.953 rs71324979 chr3:49619651 T/C cg07274523 chr3:49395745 GPX1 0.48 6.26 0.33 1.21e-9 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs3213961 0.529 rs6708 chr2:33789534 A/G cg04131969 chr2:33951647 MYADML 0.44 6.14 0.32 2.34e-9 Venous thromboembolism adjusted for sickle cell variant rs77121243-T; CRC cis rs7429990 0.932 rs11130155 chr3:48140428 A/C cg11946769 chr3:48343235 NME6 -0.45 -6.07 -0.32 3.55e-9 Educational attainment (years of education); CRC cis rs514406 0.758 rs532242 chr1:53308665 C/G cg24675658 chr1:53192096 ZYG11B -0.56 -8.08 -0.41 1.22e-14 Monocyte count; CRC cis rs7927592 0.513 rs689075 chr11:68194432 A/C cg16797656 chr11:68205561 LRP5 0.57 10.33 0.49 7.36e-22 Total body bone mineral density; CRC cis rs453301 0.686 rs13252797 chr8:8861430 A/G cg08975724 chr8:8085496 FLJ10661 0.38 5.69 0.3 2.83e-8 Joint mobility (Beighton score); CRC cis rs1451375 0.669 rs4469404 chr7:50647062 C/T cg14593290 chr7:50529359 DDC -0.52 -7.21 -0.37 3.96e-12 Malaria; CRC cis rs7312933 0.966 rs6582375 chr12:42423185 A/T cg01256987 chr12:42539512 GXYLT1 -0.44 -6.53 -0.34 2.56e-10 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CRC trans rs1455244 0.700 rs7229302 chr18:11508904 G/T cg18144860 chr5:130970833 RAPGEF6 0.4 6.33 0.33 8.14e-10 Schizophrenia; CRC cis rs3996993 0.809 rs10948723 chr6:52666405 C/T cg20803780 chr6:52668592 GSTA1 -0.35 -6.29 -0.33 1.02e-9 Hemoglobin concentration; CRC cis rs73200209 0.701 rs11609930 chr12:116644670 A/G cg01776926 chr12:116560359 MED13L -0.61 -7.08 -0.36 8.97e-12 Total body bone mineral density; CRC cis rs10504229 0.906 rs111838497 chr8:58185620 A/C cg02725872 chr8:58115012 NA -0.38 -6.43 -0.33 4.44e-10 Developmental language disorder (linguistic errors); CRC cis rs6570726 0.791 rs448939 chr6:145808320 T/C cg23711669 chr6:146136114 FBXO30 0.62 10.64 0.51 6.58e-23 Lobe attachment (rater-scored or self-reported); CRC cis rs995000 0.931 rs1627591 chr1:62989807 C/T cg19896129 chr1:63156450 NA -0.45 -6.99 -0.36 1.56e-11 Triglyceride levels; CRC cis rs897984 0.609 rs12445650 chr16:31044897 G/A cg00531865 chr16:30841666 NA -0.46 -6.45 -0.34 3.99e-10 Dementia with Lewy bodies; CRC cis rs2836950 0.545 rs2297256 chr21:40558421 C/T cg06238570 chr21:40685208 BRWD1 -0.62 -9.23 -0.45 3.44e-18 Menarche (age at onset); CRC cis rs17376456 0.877 rs10476597 chr5:93367172 C/T cg21475434 chr5:93447410 FAM172A -0.74 -7.67 -0.39 1.9e-13 Diabetic retinopathy; CRC trans rs17685 0.753 rs10245584 chr7:75745866 C/T cg19862616 chr7:65841803 NCRNA00174 0.98 18.07 0.71 3.52e-51 Coffee consumption;Coffee consumption (cups per day); CRC cis rs1046896 0.594 rs4075209 chr17:80800027 G/T cg19500275 chr17:80737654 TBCD 0.49 6.47 0.34 3.54e-10 Glycated hemoglobin levels; CRC cis rs4654899 0.758 rs7556221 chr1:21455559 C/G cg02927042 chr1:21476669 EIF4G3 -0.4 -6.45 -0.34 4e-10 Superior frontal gyrus grey matter volume; CRC cis rs7584330 0.554 rs3751105 chr2:238428459 G/A cg08992911 chr2:238395768 MLPH 0.52 6.09 0.32 3.17e-9 Prostate cancer; CRC cis rs7113874 0.569 rs9300093 chr11:8590825 T/G cg02811074 chr11:8615871 STK33 -0.34 -5.83 -0.31 1.35e-8 Body mass index in physically active individuals;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs7666738 0.925 rs34423396 chr4:99049031 T/A cg05340658 chr4:99064831 C4orf37 0.53 7.6 0.39 3.15e-13 Colonoscopy-negative controls vs population controls; CRC cis rs9443645 0.901 rs9352670 chr6:79584433 A/G cg11833968 chr6:79620685 NA -0.37 -6.48 -0.34 3.34e-10 Intelligence (multi-trait analysis); CRC cis rs7586879 0.575 rs6744205 chr2:25133148 T/C cg22495460 chr2:25135724 ADCY3 -0.89 -17.5 -0.69 6.3e-49 Body mass index; CRC cis rs7044106 0.762 rs13291660 chr9:123392748 T/C cg14255062 chr9:123606675 PSMD5;LOC253039 0.47 7.16 0.37 5.28e-12 Hip circumference adjusted for BMI; CRC cis rs4713118 0.869 rs9283882 chr6:27715258 A/C cg02683197 chr6:28174875 NA 0.63 8.77 0.44 1e-16 Parkinson's disease; CRC cis rs939584 1.000 rs4854349 chr2:647861 T/C cg03610516 chr2:642275 NA 0.41 5.93 0.31 7.83e-9 Body mass index; CRC cis rs13108904 0.967 rs4974582 chr4:1279687 C/T cg02018176 chr4:1364513 KIAA1530 0.48 7.94 0.4 3.22e-14 Obesity-related traits; CRC cis rs634534 0.562 rs1151505 chr11:65734539 C/T cg17985854 chr11:65770987 BANF1;EIF1AD 0.42 6.93 0.36 2.19e-11 Sum eosinophil basophil counts;Eosinophil counts; CRC cis rs59918340 0.764 rs3824234 chr8:142229370 T/C cg23750338 chr8:142222470 SLC45A4 0.62 11.42 0.53 1.13e-25 Immature fraction of reticulocytes; CRC cis rs12142240 0.698 rs17361819 chr1:46828109 A/G cg14993813 chr1:46806288 NSUN4 -0.49 -6.26 -0.33 1.21e-9 Menopause (age at onset); CRC cis rs1448094 0.511 rs61930590 chr12:86159959 T/A cg25456477 chr12:86230367 RASSF9 0.39 6.56 0.34 2.04e-10 Major depressive disorder; CRC cis rs8072100 1.000 rs4375701 chr17:45712218 C/T cg25173405 chr17:45401733 C17orf57 -0.47 -7.35 -0.38 1.54e-12 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs3733585 0.773 rs13107466 chr4:10019390 G/A cg11266682 chr4:10021025 SLC2A9 0.54 11.57 0.54 3.2e-26 Cleft plate (environmental tobacco smoke interaction); CRC cis rs7940866 0.834 rs2324315 chr11:130839772 C/G cg12179176 chr11:130786555 SNX19 0.6 8.76 0.43 1.05e-16 Schizophrenia; CRC cis rs7917772 0.508 rs2252147 chr10:104467774 G/A cg22532475 chr10:104410764 TRIM8 -0.41 -6.57 -0.34 1.96e-10 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC cis rs2976388 0.609 rs2376491 chr8:143790934 G/A cg20041105 chr8:143859282 LYNX1 0.43 7.8 0.4 8.09e-14 Urinary tract infection frequency; CRC cis rs7666738 0.830 rs34135615 chr4:99001325 C/T cg17366294 chr4:99064904 C4orf37 0.44 7.39 0.38 1.19e-12 Colonoscopy-negative controls vs population controls; CRC cis rs875971 0.660 rs79009421 chr7:66068509 G/C cg25985355 chr7:65971099 NA 0.32 5.73 0.3 2.3e-8 Aortic root size; CRC cis rs921968 0.643 rs559722 chr2:219398159 A/G cg02176678 chr2:219576539 TTLL4 0.48 7.99 0.4 2.28e-14 Mean corpuscular hemoglobin concentration; CRC cis rs2996428 0.561 rs2275833 chr1:3745721 C/T cg17848003 chr1:3704513 LRRC47 0.41 6.06 0.32 3.71e-9 Red cell distribution width; CRC cis rs62064224 0.606 rs61390192 chr17:30837447 C/T cg12855166 chr17:30846586 MYO1D -0.56 -8.76 -0.43 1.05e-16 Schizophrenia; CRC cis rs7223966 1.000 rs752621 chr17:61901880 G/C cg05941027 chr17:61774174 LIMD2 0.35 5.94 0.31 7.4e-9 Hip circumference adjusted for BMI;Body mass index; CRC trans rs3931020 0.720 rs927904 chr1:75260328 A/G cg01738593 chr5:133860282 NA 0.57 7.27 0.37 2.65e-12 Resistin levels; CRC cis rs6502050 0.871 rs6502051 chr17:80059332 A/C cg13198984 chr17:80129470 CCDC57 -0.47 -8.23 -0.41 4.43e-15 Life satisfaction; CRC cis rs1552244 0.882 rs9757159 chr3:10039166 C/T cg08888203 chr3:10149979 C3orf24 0.62 8.3 0.42 2.65e-15 Alzheimer's disease; CRC cis rs1552244 0.882 rs61429272 chr3:10037320 G/C cg02579736 chr3:10068473 FANCD2;CIDECP 0.93 12.04 0.55 6.69e-28 Alzheimer's disease; CRC cis rs6952808 0.689 rs2008263 chr7:2048335 A/G cg02951883 chr7:2050386 MAD1L1 -0.74 -12.17 -0.56 2.25e-28 Bipolar disorder and schizophrenia; CRC cis rs28386778 0.865 rs2727276 chr17:61929709 G/A cg07362569 chr17:61921086 SMARCD2 0.36 5.6 0.3 4.41e-8 Prudent dietary pattern; CRC cis rs992157 0.560 rs12992937 chr2:219087072 A/T cg04880052 chr2:219191631 PNKD -0.42 -6.64 -0.34 1.3100000000000001e-10 Colorectal cancer; CRC cis rs4481887 0.893 rs1339990 chr1:248509495 C/T cg13385794 chr1:248469461 NA -0.34 -6.31 -0.33 8.92e-10 Common traits (Other); CRC cis rs9894429 0.966 rs6565605 chr17:79589359 C/T cg18240062 chr17:79603768 NPLOC4 0.55 9.24 0.45 3.09e-18 Eye color traits; CRC cis rs7586879 0.796 rs916486 chr2:25082629 C/A cg04586622 chr2:25135609 ADCY3 -0.55 -9.27 -0.46 2.52e-18 Body mass index; CRC cis rs6952808 0.929 rs4721217 chr7:1973579 C/T cg21782813 chr7:2030301 MAD1L1 0.47 7.57 0.38 3.91e-13 Bipolar disorder and schizophrenia; CRC cis rs896854 0.654 rs16893776 chr8:95973604 C/T cg23172400 chr8:95962367 TP53INP1 -0.49 -8.33 -0.42 2.17e-15 Type 2 diabetes; CRC cis rs17345786 0.906 rs72944107 chr3:101197190 C/T cg11279151 chr3:101281821 RG9MTD1 -0.67 -8.33 -0.42 2.26e-15 Colonoscopy-negative controls vs population controls; CRC trans rs1728785 1.000 rs4783656 chr16:68580722 C/T cg04657470 chr2:198365150 HSPE1;HSPD1 0.58 7.07 0.36 9.08e-12 Ulcerative colitis; CRC cis rs6499255 0.904 rs12447883 chr16:69722797 T/C cg04110750 chr16:69646130 NFAT5 -0.59 -8.08 -0.41 1.25e-14 IgE levels; CRC cis rs9341808 0.718 rs9448893 chr6:80837239 A/G cg08355045 chr6:80787529 NA 0.43 6.89 0.36 2.84e-11 Sitting height ratio; CRC cis rs3015497 0.616 rs34061700 chr14:51084860 G/A cg09863266 chr14:51125203 SAV1 -0.31 -5.89 -0.31 9.3e-9 Mean platelet volume; CRC cis rs4713118 0.629 rs203889 chr6:28021775 T/G cg25164649 chr6:28176230 NA 0.65 8.79 0.44 8.45e-17 Parkinson's disease; CRC cis rs989128 0.572 rs6504674 chr17:48630814 T/C cg16068336 chr17:48637367 CACNA1G -0.48 -6.94 -0.36 2.11e-11 Type 2 diabetes; CRC cis rs7894051 1.000 rs7899476 chr10:135197214 A/G cg20534287 chr10:135191450 PAOX 0.77 6.03 0.32 4.32e-9 Lifespan; CRC cis rs6499255 0.951 rs12595878 chr16:69628217 C/T cg04110750 chr16:69646130 NFAT5 -0.56 -7.6 -0.39 3.05e-13 IgE levels; CRC cis rs9549367 0.789 rs34448227 chr13:113884754 A/C cg00898013 chr13:113819073 PROZ -0.46 -6.76 -0.35 6.4e-11 Platelet distribution width; CRC cis rs9916302 0.595 rs4795371 chr17:37636695 T/G cg00129232 chr17:37814104 STARD3 -0.53 -7.87 -0.4 5.27e-14 Glomerular filtration rate (creatinine); CRC cis rs13315871 1.000 rs9864325 chr3:58336846 A/C cg20936604 chr3:58311152 NA -0.62 -6.16 -0.32 2.08e-9 Cholesterol, total; CRC cis rs12893668 0.572 rs35011804 chr14:104151400 C/T cg01849466 chr14:104193079 ZFYVE21 -0.4 -5.91 -0.31 8.68e-9 Reticulocyte count; CRC cis rs2303759 0.551 rs7249040 chr19:49790602 C/T cg22133161 chr19:49891603 CCDC155 0.46 5.87 0.31 1.04e-8 Multiple sclerosis; CRC cis rs2228479 0.850 rs17226519 chr16:89839854 T/C cg06558623 chr16:89946397 TCF25 1.13 10.76 0.51 2.47e-23 Skin colour saturation; CRC cis rs7618915 0.532 rs13060675 chr3:52674300 T/G cg18404041 chr3:52824283 ITIH1 -0.43 -8.82 -0.44 7.03e-17 Bipolar disorder; CRC cis rs501916 0.761 rs79925748 chr15:48046412 G/C cg16110827 chr15:48056943 SEMA6D -0.53 -8.15 -0.41 7.77e-15 Inflammatory bowel disease;Ulcerative colitis; CRC cis rs1728785 1.000 rs8058314 chr16:68584151 G/A cg02972257 chr16:68554789 NA -0.58 -7.24 -0.37 3.21e-12 Ulcerative colitis; CRC cis rs12497850 0.765 rs12487580 chr3:49182932 G/A cg07636037 chr3:49044803 WDR6 0.97 15.64 0.65 1.34e-41 Parkinson's disease; CRC cis rs780096 0.526 rs12476704 chr2:27613031 C/A cg12648201 chr2:27665141 KRTCAP3 -0.32 -6.08 -0.32 3.36e-9 Total body bone mineral density; CRC cis rs7113874 0.610 rs7947670 chr11:8525531 A/C cg17679104 chr11:8615758 STK33 -0.37 -6.07 -0.32 3.45e-9 Body mass index in physically active individuals;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs2836950 0.545 rs2836952 chr21:40616651 G/C cg06238570 chr21:40685208 BRWD1 -0.61 -8.91 -0.44 3.65e-17 Menarche (age at onset); CRC cis rs4601821 0.895 rs7130431 chr11:113238223 A/C cg14159747 chr11:113255604 NA 0.5 9.42 0.46 8.33e-19 Alcoholic chronic pancreatitis; CRC cis rs4665809 0.525 rs4665324 chr2:26447147 A/C cg26119090 chr2:26468346 HADHA;HADHB -1.06 -15.53 -0.65 3.62e-41 Gut microbiome composition (summer); CRC cis rs736408 0.561 rs2276815 chr3:52853747 C/G cg11645453 chr3:52864694 ITIH4 0.56 9.76 0.47 6.35e-20 Bipolar disorder; CRC cis rs10262624 0.504 rs59865844 chr7:23733040 T/C cg20363699 chr7:23626180 CLK2P 0.35 6.15 0.32 2.27e-9 Schizophrenia; CRC cis rs853679 0.517 rs9380058 chr6:28127444 T/C cg02631126 chr6:28058918 ZSCAN12L1 0.29 5.73 0.3 2.26e-8 Depression; CRC cis rs7666738 0.761 rs13136913 chr4:98998031 C/T cg05340658 chr4:99064831 C4orf37 0.61 9.54 0.47 3.44e-19 Colonoscopy-negative controls vs population controls; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg05237023 chr16:75182837 ZFP1 0.39 6.37 0.33 6.38e-10 Liver disease severity in Alagille syndrome; CRC cis rs6831352 0.877 rs29001183 chr4:100056539 C/T cg12011299 chr4:100065546 ADH4 -0.49 -9.27 -0.45 2.61e-18 Alcohol dependence; CRC cis rs995000 0.965 rs11207980 chr1:62992749 T/C cg19896129 chr1:63156450 NA 0.4 5.91 0.31 8.43e-9 Triglyceride levels; CRC cis rs1451375 0.572 rs4948205 chr7:50557774 G/A cg14593290 chr7:50529359 DDC -0.64 -8.58 -0.43 3.92e-16 Malaria; CRC cis rs6952808 0.595 rs3778984 chr7:2166514 T/C cg21782813 chr7:2030301 MAD1L1 0.55 9.55 0.47 3.1400000000000002e-19 Bipolar disorder and schizophrenia; CRC trans rs2727020 0.754 rs10839226 chr11:49150883 C/G cg21153622 chr11:89784906 NA -0.4 -6.34 -0.33 7.52e-10 Coronary artery disease; CRC cis rs8180040 0.966 rs9683177 chr3:47490493 G/A cg02527881 chr3:46936655 PTH1R -0.41 -7.82 -0.4 7.16e-14 Colorectal cancer; CRC cis rs11229555 0.645 rs7946522 chr11:58197905 G/C cg15696309 chr11:58395628 NA -0.82 -10.31 -0.49 8.59e-22 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; CRC cis rs17826219 0.568 rs11658027 chr17:29094882 A/G cg13385521 chr17:29058706 SUZ12P -0.71 -7.95 -0.4 3.01e-14 Body mass index; CRC cis rs7843479 0.601 rs878873 chr8:21834581 T/C cg17168535 chr8:21777572 XPO7 0.61 10.47 0.5 2.51e-22 Mean corpuscular volume; CRC cis rs12134245 0.747 rs35654098 chr1:92001452 T/A cg07090678 chr1:91966139 CDC7 0.42 6.95 0.36 1.93e-11 Breast cancer; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg20777956 chr18:60987812 BCL2 0.39 6.24 0.33 1.32e-9 Liver disease severity in Alagille syndrome; CRC cis rs1218582 0.772 rs4240875 chr1:154885782 G/A cg24250549 chr1:154909240 PMVK 0.65 11.34 0.53 2.2e-25 Prostate cancer; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg26272228 chr1:95538484 ALG14 0.42 6.92 0.36 2.42e-11 Liver disease severity in Alagille syndrome; CRC cis rs4700695 0.764 rs251277 chr5:65390177 A/G cg21114390 chr5:65439923 SFRS12 -0.62 -6.72 -0.35 8.15e-11 Facial morphology (factor 19); CRC cis rs2991971 0.934 rs11580609 chr1:45975856 C/G cg24296786 chr1:45957014 TESK2 0.56 8.5 0.42 6.77e-16 High light scatter reticulocyte count; CRC cis rs6547741 1.000 rs10205364 chr2:27794233 C/T cg27432699 chr2:27873401 GPN1 0.76 13.58 0.6 1.2e-33 Oral cavity cancer; CRC cis rs4242434 0.757 rs2280104 chr8:22525980 C/T cg03733263 chr8:22462867 KIAA1967 0.94 15.99 0.66 5.43e-43 Exploratory eye movement dysfunction in schizophrenia (cognitive search score); CRC cis rs798554 0.660 rs2644275 chr7:2854010 G/A cg17321639 chr7:2759063 NA -0.4 -5.99 -0.31 5.51e-9 Height; CRC cis rs7197653 0.748 rs8063446 chr16:68344363 A/C cg05110241 chr16:68378359 PRMT7 -0.71 -6.64 -0.34 1.33e-10 Magnesium levels; CRC cis rs708547 0.647 rs781668 chr4:57825140 C/T cg25525207 chr4:57843836 C4orf14;POLR2B 0.46 6.55 0.34 2.23e-10 Response to bleomycin (chromatid breaks); CRC cis rs2839186 0.500 rs13052701 chr21:47660045 A/T cg12516959 chr21:47718080 NA -0.48 -7.91 -0.4 4.02e-14 Testicular germ cell tumor; CRC trans rs1973993 0.745 rs6683508 chr1:96955038 T/C cg10631902 chr5:14652156 NA -0.42 -7.0 -0.36 1.47e-11 Weight; CRC trans rs951252 0.504 rs11734405 chr4:146081096 C/T cg26342734 chr17:7211307 EIF5A 0.51 6.96 0.36 1.87e-11 Hip circumference; CRC cis rs7789940 1.000 rs17149161 chr7:75978229 C/A cg10167463 chr7:75959203 YWHAG -0.78 -11.33 -0.53 2.4e-25 Multiple sclerosis; CRC cis rs921968 0.565 rs4674329 chr2:219595507 A/G cg02176678 chr2:219576539 TTLL4 -0.39 -6.28 -0.33 1.05e-9 Mean corpuscular hemoglobin concentration; CRC cis rs2549003 1.000 rs2549004 chr5:131827825 C/G cg00255919 chr5:131827918 IRF1 -0.6 -12.04 -0.55 6.81e-28 Asthma (sex interaction); CRC cis rs10170846 0.626 rs9288575 chr2:223495133 A/C cg25565276 chr2:223520875 FARSB 1.11 13.43 0.6 4.2e-33 Schizophrenia (inflammation and infection response interaction); CRC cis rs1218582 0.772 rs12069356 chr1:154849771 C/T cg06221963 chr1:154839813 KCNN3 -0.81 -16.93 -0.68 1.06e-46 Prostate cancer; CRC trans rs10021731 0.668 rs11722201 chr4:115411733 C/T cg25927708 chr2:119603813 EN1 -0.33 -6.01 -0.31 4.92e-9 Optic disc area; CRC cis rs7945705 0.902 rs2568059 chr11:8884161 T/C cg00186954 chr11:8933980 ST5;C11orf17 -0.44 -7.21 -0.37 3.99e-12 Hemoglobin concentration; CRC cis rs3764400 0.564 rs1452663 chr17:46293386 C/G cg10706073 chr17:46328419 SKAP1 -0.61 -6.65 -0.34 1.23e-10 Body mass index; CRC cis rs1799949 1.000 rs8176126 chr17:41259049 A/G cg23758822 chr17:41437982 NA -0.8 -13.58 -0.6 1.14e-33 Menopause (age at onset); CRC cis rs9463078 0.625 rs500773 chr6:44888464 C/T cg25276700 chr6:44698697 NA -0.25 -6.11 -0.32 2.77e-9 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; CRC cis rs523522 0.923 rs10774553 chr12:120954984 T/C cg12219531 chr12:120966889 COQ5 0.69 9.28 0.46 2.36e-18 High light scatter reticulocyte count; CRC trans rs1346081 0.786 rs1425645 chr4:68028175 C/T cg27001607 chr7:76178636 LOC100133091 0.49 6.01 0.31 4.81e-9 Intelligence (multi-trait analysis); CRC cis rs12477438 0.520 rs11883676 chr2:99800814 G/T cg26064155 chr2:99771622 LIPT1;TSGA10 0.87 15.96 0.66 7.31e-43 Chronic sinus infection; CRC trans rs75804782 0.641 rs72983853 chr2:239324210 C/T cg01134436 chr17:81009848 B3GNTL1 0.75 7.07 0.36 9.44e-12 Morning vs. evening chronotype;Chronotype; CRC cis rs2153535 0.580 rs4587214 chr6:8454119 T/C cg21535247 chr6:8435926 SLC35B3 0.5 7.49 0.38 6.33e-13 Motion sickness; CRC cis rs1799949 1.000 rs11079056 chr17:41300799 C/A cg23758822 chr17:41437982 NA 0.79 13.45 0.6 3.6e-33 Menopause (age at onset); CRC cis rs7666738 0.830 rs58367603 chr4:99015350 T/C cg05340658 chr4:99064831 C4orf37 0.62 9.64 0.47 1.5700000000000001e-19 Colonoscopy-negative controls vs population controls; CRC cis rs9303401 0.921 rs34102441 chr17:56877414 A/G cg12560992 chr17:57184187 TRIM37 0.44 5.83 0.31 1.35e-8 Cognitive test performance; CRC cis rs1552244 0.808 rs7615088 chr3:10035896 A/T cg00166722 chr3:10149974 C3orf24 0.61 8.0 0.4 2.17e-14 Alzheimer's disease; CRC cis rs6076065 0.630 rs6083127 chr20:23424886 T/C cg11657817 chr20:23433608 CST11 0.53 8.65 0.43 2.24e-16 Facial morphology (factor 15, philtrum width); CRC cis rs317689 0.918 rs689415 chr12:69738139 A/G cg14784868 chr12:69753453 YEATS4 -0.56 -6.95 -0.36 2.03e-11 Response to diuretic therapy; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg10724491 chr3:112738377 C3orf17 0.45 6.02 0.31 4.73e-9 Anxiety disorder; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg04352944 chr11:8932751 C11orf17;ST5 0.46 6.26 0.33 1.23e-9 Anxiety disorder; CRC cis rs2073300 0.609 rs6137920 chr20:23363436 C/T cg12062639 chr20:23401060 NAPB 0.71 6.48 0.34 3.37e-10 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs10504229 0.906 rs72650894 chr8:58179734 C/T cg02290350 chr8:58132656 NA -0.42 -5.96 -0.31 6.62e-9 Developmental language disorder (linguistic errors); CRC cis rs897984 0.762 rs11150601 chr16:30977799 G/A cg02466173 chr16:30829666 NA 0.62 9.32 0.46 1.78e-18 Dementia with Lewy bodies; CRC cis rs514406 0.644 rs7529978 chr1:53204705 G/A cg08859206 chr1:53392774 SCP2 0.41 6.49 0.34 3.21e-10 Monocyte count; CRC cis rs6964587 0.626 rs34404183 chr7:91551249 T/C cg17063962 chr7:91808500 NA -0.6 -9.6 -0.47 2.04e-19 Breast cancer; CRC cis rs6426558 0.502 rs1929858 chr1:227220175 C/A cg10327440 chr1:227177885 CDC42BPA 0.45 6.75 0.35 6.76e-11 Neutrophil percentage of white cells; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg03289602 chr19:11708437 ZNF627 0.41 6.7 0.35 9.29e-11 Liver disease severity in Alagille syndrome; CRC trans rs7302981 0.510 rs860698 chr12:50486322 T/C cg18430156 chr2:187558795 FAM171B -0.36 -5.98 -0.31 5.83e-9 Systolic blood pressure; CRC cis rs853679 0.517 rs9393901 chr6:28136797 A/G cg02631126 chr6:28058918 ZSCAN12L1 0.29 5.91 0.31 8.38e-9 Depression; CRC cis rs425277 1.000 rs385039 chr1:2077409 C/T cg12639453 chr1:2035780 PRKCZ -0.33 -5.61 -0.3 4.38e-8 Height; CRC cis rs6952808 0.501 rs3778999 chr7:2180885 G/A cg22963979 chr7:1858916 MAD1L1 -0.41 -5.71 -0.3 2.57e-8 Bipolar disorder and schizophrenia; CRC cis rs7615952 0.599 rs1875683 chr3:125732481 C/G cg02772935 chr3:125709198 NA -0.52 -6.11 -0.32 2.89e-9 Blood pressure (smoking interaction); CRC cis rs11758351 1.000 rs11754744 chr6:26202605 G/A cg01420254 chr6:26195488 NA 0.84 8.64 0.43 2.44e-16 Gout;Renal underexcretion gout; CRC trans rs1455244 0.700 rs7229302 chr18:11508904 G/T cg10343723 chr19:55919467 UBE2S 0.38 6.06 0.32 3.7e-9 Schizophrenia; CRC cis rs1451375 0.572 rs3807558 chr7:50571022 A/G cg14593290 chr7:50529359 DDC -0.63 -8.39 -0.42 1.48e-15 Malaria; CRC cis rs117623576 0.715 rs11008755 chr10:32360053 C/T cg03047570 chr10:32398778 NA 0.54 6.06 0.32 3.64e-9 Anti-saccade response; CRC cis rs4664293 0.805 rs6432559 chr2:160607160 A/C cg08347373 chr2:160653686 CD302 -0.47 -7.43 -0.38 9.32e-13 Monocyte percentage of white cells; CRC cis rs28386778 0.897 rs7212196 chr17:61834981 T/C cg25654072 chr17:61904446 PSMC5;FTSJ3 0.74 11.41 0.53 1.25e-25 Prudent dietary pattern; CRC cis rs13108904 0.517 rs4974551 chr4:1336410 C/A cg21620606 chr4:1342894 KIAA1530 0.51 8.19 0.41 5.83e-15 Obesity-related traits; CRC cis rs7129220 0.925 rs7108385 chr11:10337640 T/C cg23875677 chr11:10229755 SBF2 -0.61 -5.6 -0.3 4.42e-8 Systolic blood pressure;Diastolic blood pressure;Blood pressure; CRC cis rs1044826 0.642 rs295473 chr3:139215585 T/C cg00490450 chr3:139108681 COPB2 0.43 6.43 0.33 4.53e-10 Obesity-related traits; CRC cis rs1862618 0.853 rs252921 chr5:56137787 G/A cg03609598 chr5:56110824 MAP3K1 -0.82 -10.15 -0.49 2.98e-21 Initial pursuit acceleration; CRC trans rs208520 0.690 rs12209753 chr6:66703951 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 1.04 14.83 0.63 1.82e-38 Exhaled nitric oxide output; CRC cis rs3857067 0.806 rs9307137 chr4:95135712 T/C cg11021082 chr4:95130006 SMARCAD1 -0.42 -6.24 -0.33 1.33e-9 QT interval; CRC cis rs457287 0.772 rs844511 chr9:4822521 C/G cg14182974 chr9:4791918 RCL1 0.39 5.85 0.31 1.19e-8 Platelet count; CRC cis rs9303280 0.806 rs4795399 chr17:38061439 T/C cg11212589 chr17:38028394 ZPBP2 0.42 7.7 0.39 1.59e-13 Self-reported allergy; CRC cis rs2732480 0.577 rs2634681 chr12:48733084 C/T cg21466736 chr12:48725269 NA 0.55 8.51 0.42 6.47e-16 Hemoglobin concentration;Red blood cell count;Hematocrit; CRC cis rs8014204 0.743 rs35809608 chr14:75254762 A/G cg03030879 chr14:75389066 RPS6KL1 -0.49 -7.83 -0.4 6.72e-14 Caffeine consumption; CRC cis rs3806843 0.868 rs2531349 chr5:140120953 G/A cg16607685 chr5:140181889 PCDHA2;PCDHA1;PCDHA3 0.27 6.31 0.33 8.88e-10 Depressive symptoms (multi-trait analysis); CRC cis rs28386778 0.897 rs3744293 chr17:61841788 T/A cg23090583 chr17:61904693 PSMC5;FTSJ3 1.05 20.23 0.74 1.07e-59 Prudent dietary pattern; CRC cis rs9372498 0.536 rs62424175 chr6:118797381 T/A cg24463073 chr6:118973353 C6orf204 0.55 7.11 0.36 7.38e-12 Diastolic blood pressure; CRC cis rs939658 0.805 rs6495374 chr15:79434031 C/T cg17916960 chr15:79447300 NA -0.46 -7.44 -0.38 8.91e-13 Refractive error; CRC cis rs2223471 0.837 rs2817357 chr6:50762018 C/T cg03432817 chr6:50765336 NA -0.37 -5.95 -0.31 6.68e-9 Subcutaneous adipose tissue; CRC cis rs11098499 0.661 rs10015965 chr4:120268237 A/G cg09307838 chr4:120376055 NA 0.62 9.57 0.47 2.66e-19 Corneal astigmatism; CRC cis rs4481887 0.893 rs4275482 chr1:248473506 T/C cg00666640 chr1:248458726 OR2T12 0.49 8.37 0.42 1.68e-15 Common traits (Other); CRC cis rs10256972 0.577 rs2949179 chr7:1209885 C/G cg16145915 chr7:1198662 ZFAND2A -0.6 -13.64 -0.6 7.19e-34 Longevity;Endometriosis; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg13402217 chr1:151584375 SNX27 0.41 6.38 0.33 6.02e-10 Liver disease severity in Alagille syndrome; CRC cis rs7107174 0.688 rs3740677 chr11:77928036 A/C cg02023728 chr11:77925099 USP35 0.34 5.76 0.3 1.92e-8 Testicular germ cell tumor; CRC cis rs12594515 1.000 rs6493167 chr15:45986809 G/A cg22117107 chr15:45993392 NA -0.44 -9.02 -0.45 1.58e-17 Waist circumference;Weight; CRC cis rs12928939 0.911 rs11645725 chr16:71826883 C/T cg03805757 chr16:71968109 PKD1L3 -0.47 -6.05 -0.32 4.04e-9 Post bronchodilator FEV1; CRC cis rs7737355 0.699 rs7711311 chr5:130781339 G/A cg25547332 chr5:131281432 NA -0.36 -5.74 -0.3 2.11e-8 Life satisfaction; CRC cis rs4561483 0.583 rs1019813 chr16:11940829 C/T cg08843971 chr16:11963173 GSPT1 0.5 7.63 0.39 2.59e-13 Testicular germ cell tumor; CRC cis rs2204008 0.837 rs11180549 chr12:38236950 A/G cg13010199 chr12:38710504 ALG10B 0.46 5.85 0.31 1.19e-8 Bladder cancer; CRC cis rs758324 0.741 rs10075660 chr5:131240843 C/A cg06307176 chr5:131281290 NA -0.4 -6.07 -0.32 3.6e-9 Alzheimer's disease in APOE e4- carriers; CRC cis rs10256972 0.567 rs2960835 chr7:1202963 A/G cg07092213 chr7:1199455 ZFAND2A -0.47 -6.84 -0.35 3.92e-11 Longevity;Endometriosis; CRC cis rs4713118 0.955 rs9468204 chr6:27688809 C/T cg19041857 chr6:27730383 NA -0.43 -6.05 -0.32 3.9e-9 Parkinson's disease; CRC cis rs3091242 0.933 rs34006994 chr1:25780668 C/T cg27572855 chr1:25598939 RHD -0.35 -6.08 -0.32 3.31e-9 Erythrocyte sedimentation rate; CRC cis rs2516839 0.652 rs2516841 chr1:161010774 A/G cg11578532 chr1:161008127 TSTD1 0.32 6.65 0.34 1.25e-10 Granulocyte percentage of myeloid white cells; CRC cis rs2380220 0.510 rs9387562 chr6:96057006 G/T cg15832292 chr6:96025679 MANEA 0.6 6.53 0.34 2.43e-10 Behavioural disinhibition (generation interaction); CRC cis rs3008870 0.785 rs10889651 chr1:67463513 A/T cg08660285 chr1:67390436 MIER1;WDR78 -0.57 -7.86 -0.4 5.59e-14 Lymphocyte percentage of white cells; CRC cis rs9435341 0.965 rs56111229 chr1:107566689 T/A cg14828511 chr1:107599125 PRMT6 0.47 6.52 0.34 2.67e-10 Facial morphology (factor 21, depth of nasal alae); CRC trans rs9784649 1.000 rs55924805 chr5:24999756 C/T cg11038491 chr20:34638489 LOC647979 -0.55 -6.23 -0.32 1.4e-9 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs11758351 0.866 rs2069019 chr6:26205604 C/T cg10723962 chr6:26240782 HIST1H4F -0.38 -6.0 -0.31 5.06e-9 Gout;Renal underexcretion gout; CRC cis rs12431939 0.626 rs8015848 chr14:51715021 G/A cg23942311 chr14:51606299 NA 0.54 6.98 0.36 1.6e-11 Cancer; CRC cis rs3862030 0.720 rs7081467 chr10:104231662 G/C cg11453585 chr10:104263688 ACTR1A;SUFU -0.76 -13.31 -0.59 1.26e-32 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for body mass index; CRC cis rs6951245 1.000 rs113066613 chr7:1094128 T/C cg04025307 chr7:1156635 C7orf50 0.64 6.81 0.35 4.54e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs1320333 0.685 rs6710875 chr2:699976 A/G cg20966539 chr2:681320 NA -0.58 -5.92 -0.31 7.89e-9 Obesity-related traits; CRC cis rs4481887 1.000 rs4372295 chr1:248464871 G/T cg13385794 chr1:248469461 NA 0.38 6.8 0.35 5.08e-11 Common traits (Other); CRC cis rs9611565 0.659 rs73178632 chr22:41934573 C/T cg03806693 chr22:41940476 POLR3H -1.12 -14.83 -0.63 1.91e-38 Vitiligo; CRC cis rs12931792 0.748 rs11150585 chr16:30184286 A/G cg17640201 chr16:30407289 ZNF48 0.44 6.36 0.33 6.89e-10 Tonsillectomy; CRC cis rs1046896 0.519 rs9900369 chr17:80829807 G/A cg16060761 chr17:80687452 NA -0.45 -5.91 -0.31 8.41e-9 Glycated hemoglobin levels; CRC cis rs9858542 0.953 rs9821311 chr3:49543656 C/T cg07274523 chr3:49395745 GPX1 0.46 6.23 0.32 1.43e-9 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs910316 0.935 rs175422 chr14:75627319 T/A cg03030879 chr14:75389066 RPS6KL1 0.44 6.69 0.35 9.82e-11 Height; CRC cis rs6582630 0.576 rs2387836 chr12:38560070 A/G cg13010199 chr12:38710504 ALG10B 0.43 6.2 0.32 1.71e-9 Drug-induced liver injury (flucloxacillin); CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg10735211 chr4:4310922 ZNF509 0.42 6.13 0.32 2.44e-9 Myopia (pathological); CRC cis rs7945718 0.592 rs6416153 chr11:12684263 A/G cg25843174 chr11:12811716 TEAD1 0.39 7.17 0.37 4.89e-12 Educational attainment (years of education); CRC cis rs561341 0.943 rs508566 chr17:30289861 G/C cg19193384 chr17:30244184 NA -0.65 -7.48 -0.38 6.92e-13 Hip circumference adjusted for BMI; CRC cis rs2836974 0.897 rs8132295 chr21:40527774 A/G cg11644478 chr21:40555479 PSMG1 -0.81 -13.15 -0.59 5.06e-32 Cognitive function; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg24903794 chr1:220220036 EPRS 0.43 6.03 0.32 4.46e-9 Response to antipsychotic treatment; CRC cis rs929354 1.000 rs929354 chr7:157045557 C/T cg16102536 chr7:156981717 UBE3C -0.39 -6.8 -0.35 4.96e-11 Body mass index; CRC cis rs7223966 1.000 rs2854218 chr17:61942940 A/G cg23090583 chr17:61904693 PSMC5;FTSJ3 0.58 7.08 0.36 8.73e-12 Hip circumference adjusted for BMI;Body mass index; CRC cis rs10504229 0.593 rs78459635 chr8:58004995 G/T cg08219700 chr8:58056026 NA 0.57 6.64 0.34 1.27e-10 Developmental language disorder (linguistic errors); CRC cis rs1030268 0.608 rs12707106 chr7:133311350 A/T cg10665199 chr7:133106180 EXOC4 0.64 7.71 0.39 1.48e-13 Intelligence (multi-trait analysis); CRC cis rs897984 0.609 rs55979739 chr16:31049155 A/G cg02466173 chr16:30829666 NA -0.61 -9.25 -0.45 2.95e-18 Dementia with Lewy bodies; CRC cis rs9486719 1.000 rs2145535 chr6:97034715 G/A cg06623918 chr6:96969491 KIAA0776 -0.81 -9.44 -0.46 7.3e-19 Migraine;Coronary artery disease; CRC cis rs8060686 0.920 rs73594556 chr16:67925435 G/A cg08314208 chr16:67682810 RLTPR -0.63 -7.22 -0.37 3.59e-12 HDL cholesterol;Metabolic syndrome; CRC cis rs7726839 0.540 rs72703080 chr5:595238 A/G cg09021430 chr5:549028 NA -0.7 -7.86 -0.4 5.44e-14 Obesity-related traits; CRC trans rs12458462 0.892 rs2242175 chr18:77464406 G/A cg09220050 chr20:48770642 TMEM189;TMEM189-UBE2V1 -0.46 -6.73 -0.35 7.62e-11 Monocyte count; CRC cis rs9325144 0.647 rs11168104 chr12:38857616 G/T cg26384229 chr12:38710491 ALG10B -0.5 -7.22 -0.37 3.66e-12 Morning vs. evening chronotype; CRC cis rs13191362 0.935 rs67889271 chr6:163045753 T/G cg14584255 chr6:163149320 PACRG;PARK2 0.42 5.96 0.31 6.41e-9 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs7914558 0.966 rs10883817 chr10:104755431 C/T cg15744005 chr10:104629667 AS3MT -0.34 -7.24 -0.37 3.23e-12 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs7726839 0.507 rs72703100 chr5:614291 C/T cg14541582 chr5:601475 NA -0.36 -7.29 -0.37 2.3e-12 Obesity-related traits; CRC cis rs1005277 0.579 rs2472183 chr10:38392495 T/G cg17219203 chr10:38645113 HSD17B7P2 -0.41 -5.76 -0.3 1.9e-8 Extrinsic epigenetic age acceleration; CRC trans rs2243480 1.000 rs2465120 chr7:65620974 C/G cg10756647 chr7:56101905 PSPH 0.76 7.89 0.4 4.47e-14 Diabetic kidney disease; CRC cis rs10896135 0.526 rs484262 chr11:66399681 C/T cg24851651 chr11:66362959 CCS -0.49 -8.11 -0.41 1.04e-14 Bipolar disorder; CRC cis rs4819052 1.000 rs733739 chr21:46666210 A/G cg02159808 chr21:46707872 POFUT2;LOC642852 0.64 7.83 0.4 6.94e-14 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs17376456 0.825 rs10054903 chr5:93281491 C/A cg25358565 chr5:93447407 FAM172A 1.1 10.9 0.52 7.71e-24 Diabetic retinopathy; CRC trans rs9929218 0.906 rs34565494 chr16:68741769 C/T cg04657470 chr2:198365150 HSPE1;HSPD1 -0.93 -12.29 -0.56 8.04e-29 Colorectal cancer; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg09900105 chr16:74700924 RFWD3 0.48 6.65 0.34 1.23e-10 Response to antipsychotic treatment; CRC cis rs477895 0.629 rs7130030 chr11:63933733 T/G cg04317338 chr11:64019027 PLCB3 0.57 7.01 0.36 1.33e-11 Mean platelet volume; CRC cis rs1707322 1.000 rs1768818 chr1:46514286 G/C cg03146154 chr1:46216737 IPP -0.51 -7.09 -0.36 8.16e-12 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs17065868 1.000 rs9533911 chr13:45138096 C/A cg10246903 chr13:45222710 NA 0.52 5.99 0.31 5.56e-9 Antineutrophil cytoplasmic antibody-associated vasculitis; CRC cis rs244731 0.959 rs918459 chr5:176669030 C/T cg16006841 chr5:176797999 RGS14 -0.59 -8.21 -0.41 5.01e-15 Urate levels in lean individuals; CRC cis rs28655083 0.828 rs9938028 chr16:77127830 A/C cg01753188 chr16:77233325 SYCE1L;MON1B 0.62 8.78 0.44 8.87e-17 Lobe attachment (rater-scored or self-reported); CRC cis rs7727544 0.735 rs4705933 chr5:131678412 G/A cg07395648 chr5:131743802 NA -0.42 -6.57 -0.34 1.95e-10 Blood metabolite levels; CRC cis rs10950821 0.505 rs6949755 chr7:20688042 C/G cg02470904 chr7:20686108 ABCB5 0.31 5.69 0.3 2.86e-8 Response to statin therapy; CRC cis rs13315871 0.929 rs7635697 chr3:58313706 G/A cg20936604 chr3:58311152 NA -0.76 -7.13 -0.37 6.48e-12 Cholesterol, total; CRC cis rs769267 0.501 rs2965187 chr19:19522970 T/A cg11584989 chr19:19387371 SF4 0.51 6.42 0.33 4.9e-10 Tonsillectomy; CRC cis rs6504950 0.790 rs8076984 chr17:53035428 T/C cg26251398 chr17:52985966 TOM1L1 0.42 5.62 0.3 4.01e-8 Breast cancer; CRC cis rs9443645 0.803 rs12195716 chr6:79535412 T/C cg09184832 chr6:79620586 NA -0.49 -9.07 -0.45 1.13e-17 Intelligence (multi-trait analysis); CRC trans rs6951245 1.000 rs78185801 chr7:1096367 G/A cg13565492 chr6:43139072 SRF -0.71 -7.38 -0.38 1.32e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs9768139 0.708 rs10262596 chr7:158114495 G/A cg06219351 chr7:158114137 PTPRN2 -0.6 -9.53 -0.47 3.61e-19 Calcium levels; CRC cis rs394563 0.619 rs4895787 chr6:149646500 G/A cg16235748 chr6:149772707 ZC3H12D 0.36 6.45 0.33 4.08e-10 Dupuytren's disease; CRC cis rs1448094 0.512 rs1900701 chr12:86236231 T/C cg19622623 chr12:86230825 RASSF9 -0.41 -6.74 -0.35 7.28e-11 Major depressive disorder; CRC cis rs7726839 0.540 rs7434 chr5:660804 A/G cg09021430 chr5:549028 NA 0.72 8.23 0.41 4.28e-15 Obesity-related traits; CRC cis rs6762 0.748 rs5030780 chr11:838110 C/T cg03116740 chr11:841335 TSPAN4;POLR2L -0.42 -7.21 -0.37 3.83e-12 Mean platelet volume; CRC trans rs9826463 0.757 rs73240309 chr3:142240223 A/G cg13928417 chr9:124498782 DAB2IP -0.53 -5.97 -0.31 6.09e-9 QRS duration in Tripanosoma cruzi seropositivity; CRC trans rs1728785 1.000 rs1728784 chr16:68591156 T/A cg04657470 chr2:198365150 HSPE1;HSPD1 0.77 9.05 0.45 1.31e-17 Ulcerative colitis; CRC trans rs11039798 0.591 rs74992349 chr11:49019252 G/A cg15704280 chr7:45808275 SEPT13 0.66 6.54 0.34 2.39e-10 Axial length; CRC cis rs939584 1.000 rs7569210 chr2:631462 G/A cg03610516 chr2:642275 NA 0.43 5.61 0.3 4.36e-8 Body mass index; CRC cis rs2842992 0.830 rs2495279 chr6:160138796 C/T cg11366901 chr6:160182831 ACAT2 0.94 13.05 0.58 1.21e-31 Age-related macular degeneration (geographic atrophy); CRC cis rs17767392 0.918 rs61991202 chr14:71766675 G/A cg13720639 chr14:72061746 SIPA1L1 -0.53 -6.86 -0.35 3.45e-11 Mitral valve prolapse; CRC cis rs7312933 0.558 rs1796384 chr12:42780568 G/A cg11827402 chr12:42719852 PPHLN1;ZCRB1 -0.68 -10.05 -0.48 6.87e-21 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CRC cis rs7671266 0.622 rs11943276 chr4:10403545 A/G cg00071950 chr4:10020882 SLC2A9 -0.41 -5.63 -0.3 3.95e-8 Cardiovascular disease risk factors; CRC cis rs10791097 0.720 rs4936121 chr11:130733878 A/G cg12179176 chr11:130786555 SNX19 0.71 11.67 0.54 1.47e-26 Autism spectrum disorder or schizophrenia;Schizophrenia; CRC cis rs754466 0.606 rs10824581 chr10:79599501 A/G cg17075019 chr10:79541650 NA -0.97 -17.26 -0.69 5.67e-48 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs7605827 0.897 rs2178238 chr2:15533520 C/T cg19274914 chr2:15703543 NA 0.39 5.88 0.31 9.87e-9 Educational attainment (years of education); CRC cis rs9549260 0.564 rs9549271 chr13:41295477 T/C cg21288729 chr13:41239152 FOXO1 0.39 5.93 0.31 7.46e-9 Red blood cell count; CRC cis rs4660261 0.526 rs2906458 chr1:44336389 A/G cg13606994 chr1:44402422 ARTN 0.33 5.66 0.3 3.35e-8 Intelligence (multi-trait analysis); CRC cis rs1953600 0.870 rs2573353 chr10:81940917 A/C cg04850286 chr10:81895943 PLAC9 -0.36 -6.5 -0.34 3.02e-10 Sarcoidosis; CRC cis rs875971 0.617 rs810400 chr7:66022889 G/C cg18876405 chr7:65276391 NA -0.61 -10.95 -0.52 5.42e-24 Aortic root size; CRC cis rs11105298 0.838 rs10858862 chr12:89842053 T/C cg08166232 chr12:89918718 WDR51B;GALNT4 -0.61 -7.7 -0.39 1.59e-13 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; CRC trans rs8064024 0.538 rs11076854 chr16:4929269 A/G cg19252218 chr17:41477271 ARL4D -0.41 -6.07 -0.32 3.47e-9 Cancer; CRC cis rs861020 0.606 rs695140 chr1:210005061 G/A cg05527609 chr1:210001259 C1orf107 0.77 10.66 0.51 5.37e-23 Orofacial clefts; CRC cis rs6120849 0.754 rs1885117 chr20:33600740 C/T cg08999081 chr20:33150536 PIGU 0.46 5.98 0.31 5.87e-9 Protein C levels; CRC cis rs9291683 0.588 rs3756237 chr4:10013378 G/A cg11266682 chr4:10021025 SLC2A9 0.54 11.57 0.54 3.2e-26 Bone mineral density; CRC cis rs4629180 1.000 rs6744495 chr2:102099956 T/C cg01388757 chr2:102091195 RFX8 -0.62 -8.5 -0.42 6.8e-16 Chronic rhinosinusitis with nasal polyps; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg27614038 chr3:28390080 AZI2 0.45 6.44 0.33 4.14e-10 Response to antipsychotic treatment; CRC cis rs9491140 0.539 rs10872283 chr6:124685919 G/A cg19267163 chr6:125004984 NKAIN2 0.45 6.13 0.32 2.52e-9 Neuroticism; CRC cis rs7727544 0.684 rs272874 chr5:131675046 A/G cg07395648 chr5:131743802 NA 0.42 6.3 0.33 9.59e-10 Blood metabolite levels; CRC cis rs6951245 1.000 rs78143408 chr7:1096846 G/A cg03188948 chr7:1209495 NA 0.66 6.94 0.36 2.04e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC trans rs1973993 0.689 rs17131755 chr1:96886167 G/A cg10631902 chr5:14652156 NA -0.43 -7.05 -0.36 1.06e-11 Weight; CRC cis rs9322193 0.923 rs2185352 chr6:150035776 T/G cg07701084 chr6:150067640 NUP43 0.56 8.2 0.41 5.45e-15 Lung cancer; CRC cis rs34330 0.562 rs10845615 chr12:12863470 C/T cg04607235 chr12:12878440 APOLD1 -0.68 -7.01 -0.36 1.34e-11 Systemic lupus erythematosus; CRC cis rs57221529 0.825 rs72703051 chr5:582997 G/A cg16447950 chr5:562315 NA -0.81 -9.9 -0.48 2.14e-20 Lung disease severity in cystic fibrosis; CRC trans rs12543645 0.598 rs17767186 chr8:10277494 C/T cg06636001 chr8:8085503 FLJ10661 0.46 6.56 0.34 2.07e-10 Schizophrenia; CRC cis rs2224391 1.000 rs2224391 chr6:5260936 A/C cg26165608 chr6:5261829 LYRM4;FARS2 -0.45 -5.78 -0.3 1.7e-8 Height; CRC cis rs6586163 1.000 rs6586163 chr10:90752018 A/C cg03111039 chr10:90751583 FAS;ACTA2 -0.51 -7.45 -0.38 8.36e-13 Chronic lymphocytic leukemia; CRC trans rs1346081 0.786 rs1425645 chr4:68028175 C/T cg05486825 chr12:130710349 NA 0.5 6.08 0.32 3.4e-9 Intelligence (multi-trait analysis); CRC cis rs9807989 0.507 rs10208196 chr2:102996345 G/A cg03938978 chr2:103052716 IL18RAP 0.59 10.12 0.49 3.77e-21 Asthma; CRC cis rs9287719 0.614 rs12622053 chr2:10722140 T/C cg00105475 chr2:10696890 NA 0.44 7.0 0.36 1.43e-11 Prostate cancer; CRC cis rs2361718 0.900 rs8081698 chr17:78104212 G/A cg27427491 chr17:78079615 GAA -0.37 -5.91 -0.31 8.59e-9 Yeast infection; CRC cis rs2811415 0.597 rs1044843 chr3:127783698 A/T cg13719885 chr3:127795394 NA -0.39 -5.95 -0.31 6.69e-9 Lung function (FEV1/FVC); CRC cis rs9916302 0.706 rs8067511 chr17:37611352 C/T cg07936489 chr17:37558343 FBXL20 -0.88 -10.8 -0.51 1.72e-23 Glomerular filtration rate (creatinine); CRC trans rs2243480 0.803 rs35268390 chr7:65416536 C/G cg10756647 chr7:56101905 PSPH 0.73 8.05 0.41 1.58e-14 Diabetic kidney disease; CRC cis rs4660261 0.561 rs11210934 chr1:44369435 G/A cg12908607 chr1:44402522 ARTN -0.55 -10.24 -0.49 1.58e-21 Intelligence (multi-trait analysis); CRC cis rs12541635 0.639 rs6469030 chr8:107030321 C/T cg10147462 chr8:107024639 NA 0.6 10.22 0.49 1.83e-21 Age of smoking initiation; CRC cis rs9796 0.621 rs691702 chr15:41474399 C/G cg18705301 chr15:41695430 NDUFAF1 -0.42 -6.98 -0.36 1.6e-11 Menopause (age at onset); CRC cis rs7762018 0.943 rs11546265 chr6:170108363 G/A cg17545662 chr6:170176663 C6orf70 0.53 5.86 0.31 1.12e-8 Thiazide-induced adverse metabolic effects in hypertensive patients; CRC cis rs2739330 0.796 rs2154594 chr22:24254055 A/G cg11060661 chr22:24314208 DDT;DDTL -0.45 -7.7 -0.39 1.56e-13 Liver enzyme levels (gamma-glutamyl transferase); CRC trans rs11088226 0.581 rs2016103 chr21:33878030 G/A cg09050820 chr6:167586206 TCP10L2 0.57 7.92 0.4 3.76e-14 Gastritis; CRC cis rs13108904 0.518 rs4974602 chr4:1342391 C/T cg15763984 chr4:1342303 KIAA1530 0.47 7.43 0.38 9.18e-13 Obesity-related traits; CRC cis rs4713118 0.869 rs9468214 chr6:27713299 G/C cg12273811 chr6:28175739 NA 0.56 7.88 0.4 4.8e-14 Parkinson's disease; CRC cis rs9467711 0.651 rs13191776 chr6:25955741 C/T cg16898833 chr6:26189333 HIST1H4D 0.69 5.66 0.3 3.23e-8 Autism spectrum disorder or schizophrenia; CRC cis rs7618915 0.547 rs62255362 chr3:52699741 C/G cg05573699 chr3:52720067 GNL3;PBRM1 -0.47 -6.77 -0.35 6.02e-11 Bipolar disorder; CRC cis rs3806843 1.000 rs991918 chr5:140194858 C/T cg16607685 chr5:140181889 PCDHA2;PCDHA1;PCDHA3 -0.26 -5.9 -0.31 9.04e-9 Depressive symptoms (multi-trait analysis); CRC cis rs270601 0.770 rs1007602 chr5:131602166 T/C cg09877947 chr5:131593287 PDLIM4 0.53 9.94 0.48 1.53e-20 Acylcarnitine levels; CRC cis rs4555082 0.681 rs28588570 chr14:105709606 A/T cg18132624 chr14:105716052 BTBD6;BRF1 -0.44 -7.29 -0.37 2.34e-12 Mean platelet volume;Platelet distribution width; CRC cis rs7647973 0.560 rs7638154 chr3:49299375 C/A cg20833759 chr3:49053208 WDR6;DALRD3 0.4 6.41 0.33 4.92e-10 Menarche (age at onset); CRC cis rs7552404 1.000 rs12091720 chr1:76186949 G/A cg03433033 chr1:76189801 ACADM 0.81 11.1 0.52 1.55e-24 Blood metabolite levels;Acylcarnitine levels; CRC cis rs7737355 0.853 rs26005 chr5:130988029 A/G cg06307176 chr5:131281290 NA 0.42 6.22 0.32 1.48e-9 Life satisfaction; CRC cis rs853679 0.517 rs9368551 chr6:28061792 A/G cg15786705 chr6:28176104 NA 0.76 9.63 0.47 1.68e-19 Depression; CRC cis rs1534166 1.000 rs1534166 chr3:133537067 C/T cg27366882 chr3:133540807 NA 0.55 7.48 0.38 7.04e-13 Alcohol consumption (transferrin glycosylation); CRC cis rs2882667 0.824 rs1560656 chr5:138470789 A/G cg09476006 chr5:138032270 NA -0.42 -6.5 -0.34 3.01e-10 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs67478160 0.619 rs11623546 chr14:104269098 A/G cg01849466 chr14:104193079 ZFYVE21 -0.47 -8.2 -0.41 5.63e-15 Schizophrenia; CRC cis rs9486715 0.867 rs2475025 chr6:96988696 A/T cg18709589 chr6:96969512 KIAA0776 -0.51 -7.51 -0.38 5.74e-13 Headache; CRC cis rs6951245 0.554 rs11544331 chr7:1131411 C/T cg18297960 chr7:1142765 C7orf50 -0.44 -5.9 -0.31 8.97e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs1448094 0.522 rs12313658 chr12:86271063 C/T cg19622623 chr12:86230825 RASSF9 -0.41 -6.72 -0.35 7.89e-11 Major depressive disorder; CRC trans rs3780486 0.881 rs10738906 chr9:33135634 T/C cg20290983 chr6:43655470 MRPS18A 1.16 25.31 0.81 3.42e-79 IgG glycosylation; CRC cis rs7680126 0.596 rs4698009 chr4:10284993 A/G cg00071950 chr4:10020882 SLC2A9 -0.43 -5.93 -0.31 7.79e-9 Urate levels in lean individuals;Urate levels in overweight individuals;Urate levels in obese individuals; CRC cis rs992157 0.798 rs4674284 chr2:219161241 C/T cg04731861 chr2:219085781 ARPC2 0.31 6.36 0.33 6.89e-10 Colorectal cancer; CRC cis rs2737618 0.674 rs2249150 chr1:200083654 G/A cg21825944 chr1:200113062 NR5A2 -0.5 -7.37 -0.38 1.38e-12 Uric acid levels; CRC cis rs4660214 0.666 rs4660550 chr1:39688459 A/T cg11070191 chr1:39582205 MACF1 0.36 5.61 0.3 4.28e-8 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs736408 0.812 rs1075653 chr3:52825528 T/C cg10802521 chr3:52805072 NEK4 -0.45 -6.52 -0.34 2.61e-10 Bipolar disorder; CRC cis rs9891119 0.965 rs3736161 chr17:40497835 C/G cg06270615 chr17:40516068 STAT3 -0.27 -5.9 -0.31 8.79e-9 Multiple sclerosis;Crohn's disease; CRC cis rs2276314 0.857 rs62101393 chr18:33592168 T/C cg19628046 chr18:33552617 C18orf21 0.49 6.68 0.35 1.02e-10 Endometriosis;Drug-induced torsades de pointes; CRC cis rs2180341 0.618 rs6683 chr6:127610021 G/A cg24812749 chr6:127587940 RNF146 0.62 9.32 0.46 1.79e-18 Breast cancer; CRC cis rs9527 0.830 rs11191440 chr10:104641511 G/A cg15744005 chr10:104629667 AS3MT -0.35 -6.5 -0.34 2.89e-10 Arsenic metabolism; CRC cis rs1881797 1.000 rs7527856 chr1:247688139 C/T cg11166453 chr1:247681781 NA 0.41 6.69 0.35 9.75e-11 Acute lymphoblastic leukemia (childhood); CRC cis rs10504229 0.636 rs72649133 chr8:58054681 G/A cg02725872 chr8:58115012 NA -0.56 -7.62 -0.39 2.74e-13 Developmental language disorder (linguistic errors); CRC cis rs2739330 0.731 rs2000468 chr22:24241611 G/T cg11905131 chr22:24372483 LOC391322 -0.67 -10.59 -0.5 9.77e-23 Liver enzyme levels (gamma-glutamyl transferase); CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg12445461 chr9:6681608 NA -0.5 -6.09 -0.32 3.14e-9 Diisocyanate-induced asthma; CRC cis rs826838 1.000 rs1963562 chr12:38662896 C/T cg26384229 chr12:38710491 ALG10B 0.72 10.23 0.49 1.61e-21 Heart rate; CRC cis rs72945132 0.714 rs117232799 chr11:70157182 G/A cg14191688 chr11:70257035 CTTN 0.59 7.19 0.37 4.29e-12 Coronary artery disease; CRC cis rs826838 0.806 rs826873 chr12:39121305 G/A cg26384229 chr12:38710491 ALG10B -0.62 -9.4 -0.46 9.64e-19 Heart rate; CRC cis rs1865760 0.534 rs2032444 chr6:26046744 T/G cg17691542 chr6:26056736 HIST1H1C 0.63 8.78 0.44 9e-17 Height; CRC cis rs3767633 0.858 rs2341468 chr1:161862312 G/A cg09175582 chr1:161736000 ATF6 0.7 6.29 0.33 1.03e-9 IgG glycosylation; CRC cis rs4780355 0.776 rs9936459 chr16:11437779 C/T cg00044050 chr16:11439710 C16orf75 -0.43 -5.97 -0.31 6.04e-9 Crohn's disease and psoriasis; CRC cis rs2242116 0.932 rs7646906 chr3:46949379 G/A cg02527881 chr3:46936655 PTH1R -0.52 -9.83 -0.48 3.65e-20 Birth weight; CRC cis rs7487075 0.930 rs6582656 chr12:46843416 A/G cg22049899 chr12:47219821 SLC38A4 0.32 6.33 0.33 8.1e-10 Itch intensity from mosquito bite; CRC cis rs28386778 0.897 rs2036911 chr17:61794839 A/T cg23090583 chr17:61904693 PSMC5;FTSJ3 1.03 19.02 0.72 6.2e-55 Prudent dietary pattern; CRC cis rs6570726 0.791 rs10457788 chr6:145921136 T/A cg13319975 chr6:146136371 FBXO30 -0.46 -6.82 -0.35 4.43e-11 Lobe attachment (rater-scored or self-reported); CRC cis rs1355223 0.525 rs7129517 chr11:34872236 A/C cg11058730 chr11:34937778 PDHX;APIP -0.42 -5.9 -0.31 9.11e-9 Systemic lupus erythematosus and Systemic sclerosis; CRC cis rs10256972 0.521 rs7457418 chr7:1110255 C/T cg03923535 chr7:1197113 ZFAND2A 0.53 7.6 0.39 3.1e-13 Longevity;Endometriosis; CRC cis rs9649465 0.967 rs3779261 chr7:123315174 A/G cg03229431 chr7:123269106 ASB15 -0.36 -5.74 -0.3 2.13e-8 Migraine; CRC cis rs728616 0.614 rs59806247 chr10:82097974 T/C cg05935833 chr10:81318306 SFTPA2 -0.48 -6.57 -0.34 1.95e-10 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs11212617 0.967 rs1003624 chr11:108152645 A/G cg12106634 chr11:108092400 ATM;NPAT 0.42 6.12 0.32 2.71e-9 Response to metformin in type 2 diabetes (glycemic); CRC cis rs9457247 1.000 rs415842 chr6:167406681 G/A cg23791538 chr6:167370224 RNASET2 -0.38 -5.94 -0.31 7.32e-9 Crohn's disease; CRC cis rs7811142 0.830 rs7341507 chr7:99951315 A/G cg00814883 chr7:100076585 TSC22D4 -0.69 -8.81 -0.44 7.12e-17 Platelet count; CRC cis rs4481887 1.000 rs10788782 chr1:248496132 C/A cg00666640 chr1:248458726 OR2T12 0.55 9.38 0.46 1.1e-18 Common traits (Other); CRC cis rs3785574 0.962 rs2727331 chr17:61926990 G/T cg23090583 chr17:61904693 PSMC5;FTSJ3 0.63 8.94 0.44 2.86e-17 Height; CRC cis rs7223966 1.000 rs11871767 chr17:61698723 A/G cg05941027 chr17:61774174 LIMD2 0.35 6.32 0.33 8.46e-10 Hip circumference adjusted for BMI;Body mass index; CRC cis rs208520 0.690 rs3846808 chr6:66818604 A/G cg07460842 chr6:66804631 NA -1.05 -14.58 -0.63 1.67e-37 Exhaled nitric oxide output; CRC cis rs6951245 1.000 rs79617366 chr7:1111958 G/C cg21664854 chr7:1097933 C7orf50;GPR146 0.78 8.91 0.44 3.56e-17 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs875971 0.862 rs12537823 chr7:65720884 C/T cg18252515 chr7:66147081 NA -0.4 -5.82 -0.31 1.4e-8 Aortic root size; CRC cis rs1552244 1.000 rs55882090 chr3:10139082 C/T cg00166722 chr3:10149974 C3orf24 0.63 8.78 0.44 9.09e-17 Alzheimer's disease; CRC cis rs1448094 0.817 rs10863111 chr12:86330615 T/C cg02569458 chr12:86230093 RASSF9 0.46 7.68 0.39 1.89e-13 Major depressive disorder; CRC cis rs7618915 0.501 rs2336149 chr3:52692124 G/A cg10802521 chr3:52805072 NEK4 -0.56 -8.89 -0.44 4.12e-17 Bipolar disorder; CRC cis rs1712517 0.844 rs1163081 chr10:105029840 G/C cg05636881 chr10:105038444 INA 0.48 8.64 0.43 2.41e-16 Migraine; CRC cis rs9911578 0.867 rs4793941 chr17:56472366 G/A cg12560992 chr17:57184187 TRIM37 -0.85 -14.72 -0.63 4.99e-38 Intelligence (multi-trait analysis); CRC cis rs6964587 1.000 rs926192 chr7:91671853 C/A cg17063962 chr7:91808500 NA 0.83 14.87 0.63 1.25e-38 Breast cancer; CRC cis rs4731207 0.596 rs12539580 chr7:124619404 C/T cg23710748 chr7:124431027 NA -0.39 -6.25 -0.33 1.29e-9 Cutaneous malignant melanoma; CRC cis rs2439831 0.681 rs956391 chr15:43617493 C/T cg15269541 chr15:43626905 ADAL 0.43 5.76 0.3 1.93e-8 Lung cancer in ever smokers; CRC cis rs370915 0.564 rs10027461 chr4:187837608 T/C cg19519643 chr4:187840862 NA -0.63 -10.74 -0.51 2.99e-23 Gout; CRC cis rs838147 0.537 rs485186 chr19:49207206 A/G cg21064579 chr19:49206444 FUT2 0.5 8.63 0.43 2.58e-16 Dietary macronutrient intake; CRC cis rs7129220 0.512 rs1867136 chr11:10228843 C/T cg23875677 chr11:10229755 SBF2 -0.53 -5.97 -0.31 6.29e-9 Systolic blood pressure;Diastolic blood pressure;Blood pressure; CRC trans rs561341 1.000 rs8069199 chr17:30281845 A/G cg27661571 chr11:113659931 NA -0.77 -9.59 -0.47 2.24e-19 Hip circumference adjusted for BMI; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg25456515 chr11:125439230 EI24 0.41 6.38 0.33 6.04e-10 Intelligence (multi-trait analysis); CRC cis rs58688157 0.705 rs12803132 chr11:586696 A/G cg09218773 chr11:619014 MUPCDH -0.42 -5.95 -0.31 6.73e-9 Systemic lupus erythematosus; CRC cis rs67478160 0.619 rs10083370 chr14:104314182 G/A cg01849466 chr14:104193079 ZFYVE21 0.47 8.17 0.41 6.84e-15 Schizophrenia; CRC cis rs4713118 0.715 rs200480 chr6:27773664 A/G cg21251018 chr6:28226885 NKAPL 0.47 7.46 0.38 7.96e-13 Parkinson's disease; CRC trans rs61931739 0.500 rs11053243 chr12:34514155 T/C cg13010199 chr12:38710504 ALG10B 0.45 6.51 0.34 2.88e-10 Morning vs. evening chronotype; CRC cis rs1129187 0.755 rs9471976 chr6:42920549 G/T cg26304593 chr6:42947056 PEX6 -0.46 -6.78 -0.35 5.65e-11 Alzheimer's disease in APOE e4+ carriers; CRC cis rs1005277 0.579 rs2749612 chr10:38488610 G/A cg00409905 chr10:38381863 ZNF37A -0.64 -10.42 -0.5 3.7e-22 Extrinsic epigenetic age acceleration; CRC cis rs7666738 0.791 rs28858828 chr4:98950442 C/G cg17366294 chr4:99064904 C4orf37 0.43 7.34 0.38 1.69e-12 Colonoscopy-negative controls vs population controls; CRC trans rs11466653 1.000 rs9996228 chr4:38777517 A/C cg11403706 chr22:49042600 FAM19A5 0.62 6.11 0.32 2.76e-9 Peripheral arterial disease (traffic-related air pollution interaction); CRC trans rs2553218 0.690 rs8032415 chr15:54851945 A/G cg06128509 chr10:91461539 KIF20B 0.48 6.52 0.34 2.69e-10 Immune response to smallpox vaccine (IL-6); CRC cis rs6500395 0.802 rs13330784 chr16:48661530 A/C cg04672837 chr16:48644449 N4BP1 0.42 6.3 0.33 9.56e-10 Response to tocilizumab in rheumatoid arthritis; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg06866400 chr6:143771904 ADAT2;PEX3 0.41 6.54 0.34 2.37e-10 Liver disease severity in Alagille syndrome; CRC cis rs9894429 0.966 rs6565604 chr17:79589242 G/A cg21984481 chr17:79567631 NPLOC4 -0.53 -9.8 -0.48 4.72e-20 Eye color traits; CRC cis rs2200578 1.000 rs62153845 chr2:99887162 C/T cg26064155 chr2:99771622 LIPT1;TSGA10 0.59 6.42 0.33 4.85e-10 IgG glycosylation; CRC cis rs3768617 0.510 rs2296291 chr1:183079509 C/T ch.1.3577855R chr1:183094577 LAMC1 0.88 15.62 0.65 1.5e-41 Fuchs's corneal dystrophy; CRC cis rs904251 0.523 rs10807184 chr6:37483713 C/T cg25019722 chr6:37503610 NA -0.41 -7.37 -0.38 1.4e-12 Cognitive performance; CRC cis rs34779708 0.897 rs12764820 chr10:35386321 G/A cg03585969 chr10:35415529 CREM 0.67 8.87 0.44 4.78e-17 Inflammatory bowel disease;Crohn's disease; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg20696051 chr7:158649028 WDR60 0.51 6.55 0.34 2.18e-10 Thyroid stimulating hormone; CRC cis rs12347191 0.500 rs907580 chr9:100622597 T/C cg13688889 chr9:100608707 NA -0.47 -5.92 -0.31 8.1e-9 Orofacial clefts; CRC cis rs2576037 0.901 rs6507719 chr18:44581310 A/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 -0.48 -7.81 -0.4 7.99e-14 Personality dimensions; CRC cis rs2303745 0.589 rs10401700 chr19:17397700 A/C cg02221750 chr19:17393354 ANKLE1 -0.43 -6.85 -0.35 3.63e-11 Systemic lupus erythematosus; CRC cis rs4604732 0.631 rs10802509 chr1:247627158 C/T cg12754571 chr1:247694271 LOC148824;OR2C3 0.41 5.78 0.3 1.74e-8 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CRC trans rs4942242 0.663 rs9525817 chr13:44225189 C/T cg27382691 chr15:76552771 ETFA;TYRO3P 0.51 6.4 0.33 5.33e-10 Response to tocilizumab in rheumatoid arthritis; CRC cis rs4665809 1.000 rs4665304 chr2:26313406 C/T cg22920501 chr2:26401640 FAM59B -0.52 -7.22 -0.37 3.61e-12 Gut microbiome composition (summer); CRC cis rs10746514 1.000 rs12129814 chr1:232251730 C/A cg09506761 chr1:232265262 NA 0.43 5.63 0.3 3.79e-8 Response to statin therapy; CRC cis rs853679 0.882 rs9468287 chr6:28079741 G/T cg15845792 chr6:28175446 NA 0.78 6.24 0.33 1.31e-9 Depression; CRC cis rs12477438 0.520 rs7572660 chr2:99788582 A/G cg14399236 chr2:99771627 LIPT1;TSGA10 0.81 14.3 0.62 2.11e-36 Chronic sinus infection; CRC cis rs2032447 0.933 rs1540275 chr6:26036476 T/C cg04800585 chr6:26043546 HIST1H2BB 0.56 8.36 0.42 1.79e-15 Intelligence (multi-trait analysis); CRC cis rs13118159 0.509 rs7688922 chr4:1361011 T/C cg16405210 chr4:1374714 KIAA1530 -0.91 -14.16 -0.62 7.04e-36 Longevity; CRC cis rs561341 0.556 rs542244 chr17:30307242 T/C cg23018236 chr17:30244563 NA -0.67 -8.02 -0.4 1.83e-14 Hip circumference adjusted for BMI; CRC cis rs6951245 1.000 rs74347384 chr7:1072440 G/A cg20603222 chr7:1096387 C7orf50;GPR146 -0.69 -8.1 -0.41 1.07e-14 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs73200209 0.744 rs56911341 chr12:116682872 A/C cg01776926 chr12:116560359 MED13L -0.61 -7.27 -0.37 2.66e-12 Total body bone mineral density; CRC cis rs17767392 0.881 rs8017775 chr14:72029436 A/G cg13720639 chr14:72061746 SIPA1L1 0.53 6.51 0.34 2.87e-10 Mitral valve prolapse; CRC cis rs1799949 0.965 rs33988650 chr17:41287880 A/G cg25072359 chr17:41440525 NA 0.46 6.97 0.36 1.79e-11 Menopause (age at onset); CRC cis rs1185460 0.967 rs1184902 chr11:118945337 A/G cg23280166 chr11:118938394 VPS11 0.43 6.47 0.34 3.62e-10 Coronary artery disease; CRC cis rs9649213 0.593 rs3779193 chr7:98028466 T/C cg21770322 chr7:97807741 LMTK2 0.52 8.49 0.42 7.38e-16 Prostate cancer (SNP x SNP interaction); CRC cis rs8180040 0.966 rs9683177 chr3:47490493 G/A cg27129171 chr3:47204927 SETD2 0.52 8.15 0.41 7.57e-15 Colorectal cancer; CRC cis rs3767633 0.858 rs6698065 chr1:161891528 G/A cg09175582 chr1:161736000 ATF6 0.65 6.17 0.32 1.95e-9 IgG glycosylation; CRC trans rs1455244 0.700 rs7229302 chr18:11508904 G/T cg13530292 chr19:42721476 DEDD2 0.42 6.17 0.32 2.01e-9 Schizophrenia; CRC cis rs1800682 0.528 rs11202918 chr10:90742008 A/G cg03111039 chr10:90751583 FAS;ACTA2 0.76 11.46 0.53 7.94e-26 Chronic lymphocytic leukemia; CRC trans rs875971 0.545 rs7783889 chr7:65748353 T/A cg02869306 chr7:64672164 INTS4L1 -0.44 -6.46 -0.34 3.83e-10 Aortic root size; CRC trans rs2303319 0.504 rs62189042 chr2:162602320 G/T cg10498984 chr16:28874827 SH2B1 -0.73 -6.3 -0.33 9.75e-10 Cognitive function; CRC cis rs62064224 0.614 rs4794923 chr17:30763009 G/A cg21839984 chr17:30846986 MYO1D -0.36 -6.06 -0.32 3.64e-9 Schizophrenia; CRC trans rs11722228 0.508 rs73212864 chr4:10104191 G/A cg26043149 chr18:55253948 FECH 1.12 17.14 0.69 1.66e-47 Gout;Urate levels;Serum uric acid levels; CRC cis rs7044106 0.762 rs10984974 chr9:123421556 C/T cg14255062 chr9:123606675 PSMD5;LOC253039 0.44 6.71 0.35 8.52e-11 Hip circumference adjusted for BMI; CRC cis rs868943 0.743 rs11153591 chr6:116328533 A/T cg15226275 chr6:116381976 FRK 0.32 7.68 0.39 1.78e-13 Total cholesterol levels; CRC cis rs11997175 0.583 rs12680755 chr8:33815282 G/A cg04338863 chr8:33670619 NA 0.44 6.55 0.34 2.28e-10 Body mass index; CRC cis rs7259376 0.936 rs10404998 chr19:22608374 T/C cg02657401 chr19:22469223 NA 0.31 6.68 0.35 1.01e-10 Menopause (age at onset); CRC cis rs6724607 1.000 rs10165399 chr2:191441595 A/G cg27211696 chr2:191398769 TMEM194B 0.41 6.3 0.33 9.75e-10 Pulse pressure; CRC cis rs2204008 0.837 rs12369089 chr12:38060263 G/A cg26384229 chr12:38710491 ALG10B 0.69 9.17 0.45 5.4e-18 Bladder cancer; CRC trans rs1005277 0.579 rs2474586 chr10:38418882 T/C cg27523141 chr10:43048294 ZNF37B 0.49 7.18 0.37 4.79e-12 Extrinsic epigenetic age acceleration; CRC cis rs951366 0.789 rs823097 chr1:205681370 G/A cg07167872 chr1:205819463 PM20D1 0.75 11.07 0.52 2e-24 Menarche (age at onset); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg25179170 chr1:93427589 FAM69A 0.44 6.35 0.33 7.06e-10 Response to antipsychotic treatment; CRC cis rs6724607 1.000 rs13006708 chr2:191471428 G/A cg21644426 chr2:191273491 MFSD6 -0.44 -5.84 -0.31 1.24e-8 Pulse pressure; CRC cis rs2153535 0.580 rs9392224 chr6:8472614 G/A cg21535247 chr6:8435926 SLC35B3 0.5 7.53 0.38 4.89e-13 Motion sickness; CRC cis rs9916302 0.904 rs1966916 chr17:37425238 T/G cg00129232 chr17:37814104 STARD3 -0.54 -8.07 -0.41 1.29e-14 Glomerular filtration rate (creatinine); CRC cis rs977987 0.843 rs12443904 chr16:75438770 C/T cg03315344 chr16:75512273 CHST6 0.51 8.66 0.43 2.08e-16 Dupuytren's disease; CRC cis rs9733 0.596 rs72702573 chr1:150689050 C/T cg15448220 chr1:150897856 SETDB1 0.45 6.41 0.33 5.09e-10 Tonsillectomy; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg12474983 chr10:43903196 HNRNPF 0.4 6.01 0.31 5.04e-9 Liver disease severity in Alagille syndrome; CRC trans rs561341 1.000 rs564714 chr17:30318404 C/T cg20587970 chr11:113659929 NA -1.43 -20.16 -0.74 1.97e-59 Hip circumference adjusted for BMI; CRC cis rs1707322 0.721 rs6697821 chr1:46216722 A/G cg06784218 chr1:46089804 CCDC17 0.66 12.3 0.56 7.04e-29 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs1965732 1.000 rs11696000 chr2:3709907 A/G cg19052272 chr2:3704530 ALLC -0.5 -7.13 -0.37 6.48e-12 Response to inhaled corticosteroid treatment in asthma (change in FEV1); CRC cis rs709400 1.000 rs8018979 chr14:104109087 G/A cg12935359 chr14:103987150 CKB -0.37 -6.14 -0.32 2.44e-9 Body mass index; CRC cis rs4665809 0.567 rs12999875 chr2:26414847 A/C cg04944784 chr2:26401820 FAM59B 0.83 10.63 0.51 6.75e-23 Gut microbiome composition (summer); CRC trans rs1814175 0.715 rs11040586 chr11:49858432 T/A cg15704280 chr7:45808275 SEPT13 -0.96 -18.34 -0.71 3.01e-52 Height; CRC cis rs9747201 0.962 rs11656153 chr17:80072950 G/A cg02741985 chr17:80059408 CCDC57 -0.42 -5.64 -0.3 3.6e-8 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs208520 0.545 rs6899712 chr6:66749670 T/C cg07460842 chr6:66804631 NA 1.09 20.25 0.74 8.92e-60 Exhaled nitric oxide output; CRC cis rs9522267 0.502 rs9515450 chr13:112234262 T/C cg14352298 chr13:112236639 NA 0.29 6.63 0.34 1.38e-10 Hepatitis; CRC cis rs6951245 1.000 rs79422648 chr7:1080241 T/C cg18402987 chr7:1209562 NA 0.64 6.78 0.35 5.48e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs270601 0.739 rs1979981 chr5:131601720 G/A cg09877947 chr5:131593287 PDLIM4 0.53 9.94 0.48 1.53e-20 Acylcarnitine levels; CRC cis rs1129187 0.755 rs9471985 chr6:42941324 T/C cg02359409 chr6:42947317 PEX6 -0.69 -11.68 -0.54 1.36e-26 Alzheimer's disease in APOE e4+ carriers; CRC cis rs4819052 0.851 rs8134392 chr21:46663790 A/G cg11663144 chr21:46675770 NA 0.82 14.0 0.61 3.05e-35 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs1552244 0.935 rs7621551 chr3:10114205 C/T cg08888203 chr3:10149979 C3orf24 0.73 10.16 0.49 2.86e-21 Alzheimer's disease; CRC cis rs7274811 0.681 rs158676 chr20:31974395 G/A cg03904042 chr20:32255491 NECAB3;C20orf134 0.44 6.39 0.33 5.54e-10 Height; CRC cis rs9611565 0.512 rs5751148 chr22:42139078 A/G cg06634786 chr22:41940651 POLR3H 0.68 7.6 0.39 3.04e-13 Vitiligo; CRC cis rs7923609 0.905 rs7092784 chr10:65214749 C/T cg08743896 chr10:65200160 JMJD1C -0.42 -6.12 -0.32 2.65e-9 Educational attainment;Liver enzyme levels (alkaline phosphatase); CRC cis rs921968 0.548 rs13427522 chr2:219438359 C/T cg02176678 chr2:219576539 TTLL4 0.47 7.86 0.4 5.36e-14 Mean corpuscular hemoglobin concentration; CRC cis rs1707322 1.000 rs11211232 chr1:46411146 C/T cg03146154 chr1:46216737 IPP 0.57 7.98 0.4 2.54e-14 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs875971 1.000 rs10244498 chr7:66116056 A/G cg12463550 chr7:65579703 CRCP 0.47 6.47 0.34 3.47e-10 Aortic root size; CRC cis rs216026 0.689 rs4765701 chr12:2770891 C/T cg19945202 chr12:2788847 CACNA1C 0.45 6.48 0.34 3.42e-10 Fractional exhaled nitric oxide (childhood); CRC cis rs17608059 1.000 rs17608059 chr17:13910549 C/T cg11395062 chr17:14139857 CDRT15 0.52 8.11 0.41 9.83e-15 Temperament; CRC cis rs8077889 1.000 rs2342310 chr17:41866199 T/C cg25876840 chr17:41920477 NA 0.56 7.59 0.39 3.26e-13 Triglycerides; CRC cis rs1691799 0.899 rs1168351 chr12:66752505 A/G cg16791601 chr12:66731901 HELB -0.73 -12.87 -0.58 5.39e-31 White blood cell count (basophil); CRC cis rs67311347 0.544 rs9814779 chr3:40340431 T/C cg09455208 chr3:40491958 NA 0.31 6.34 0.33 7.75e-10 Renal cell carcinoma; CRC cis rs728616 0.867 rs17883671 chr10:81695193 C/T cg05935833 chr10:81318306 SFTPA2 -0.72 -8.19 -0.41 5.66e-15 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs9916302 0.904 rs12450559 chr17:37694709 G/A cg00129232 chr17:37814104 STARD3 -0.56 -8.27 -0.41 3.44e-15 Glomerular filtration rate (creatinine); CRC cis rs3806843 0.900 rs2563279 chr5:140131535 G/A cg19875535 chr5:140030758 IK -0.52 -8.16 -0.41 6.97e-15 Depressive symptoms (multi-trait analysis); CRC cis rs6502050 0.871 rs62079998 chr17:80077245 A/C cg19223190 chr17:80058835 NA -0.41 -6.54 -0.34 2.36e-10 Life satisfaction; CRC cis rs2404602 0.735 rs2280306 chr15:76652258 C/G cg23625390 chr15:77176239 SCAPER -0.85 -13.59 -0.6 1.05e-33 Blood metabolite levels; CRC cis rs7172677 0.768 rs34180494 chr15:75370012 A/C cg14664628 chr15:75095509 CSK 0.52 6.08 0.32 3.34e-9 Systemic lupus erythematosus and Systemic sclerosis; CRC cis rs853679 0.599 rs202906 chr6:28011652 C/T cg15786705 chr6:28176104 NA -0.67 -6.63 -0.34 1.37e-10 Depression; CRC trans rs7647973 0.710 rs6446285 chr3:49626306 G/A cg21659725 chr3:3221576 CRBN -0.64 -6.07 -0.32 3.52e-9 Menarche (age at onset); CRC cis rs9372498 0.536 rs25422 chr6:118807847 A/G cg15382696 chr6:118971807 C6orf204 -0.56 -6.76 -0.35 6.22e-11 Diastolic blood pressure; CRC cis rs801193 1.000 rs11773829 chr7:66141074 G/A cg18876405 chr7:65276391 NA -0.61 -10.81 -0.51 1.58e-23 Aortic root size; CRC cis rs9527 0.590 rs2066322 chr10:104909339 T/G cg15744005 chr10:104629667 AS3MT -0.3 -5.89 -0.31 9.3e-9 Arsenic metabolism; CRC cis rs12220238 1.000 rs10824090 chr10:75923446 C/T cg19889307 chr10:75911429 ADK;AP3M1 0.61 6.12 0.32 2.67e-9 Soluble interleukin-2 receptor subunit alpha; CRC cis rs6762 0.692 rs5030778 chr11:836008 T/C cg07691484 chr11:842764 TSPAN4;POLR2L -0.57 -8.41 -0.42 1.29e-15 Mean platelet volume; CRC cis rs853679 0.517 rs9393885 chr6:28050009 A/T cg15786705 chr6:28176104 NA 0.74 9.57 0.47 2.68e-19 Depression; CRC cis rs6831352 0.879 rs34360292 chr4:100051303 T/C cg12011299 chr4:100065546 ADH4 -0.49 -9.27 -0.45 2.61e-18 Alcohol dependence; CRC cis rs4474465 0.850 rs10751292 chr11:78242201 C/G cg27205649 chr11:78285834 NARS2 0.52 6.68 0.35 1.02e-10 Alzheimer's disease (survival time); CRC cis rs9487051 0.676 rs6910119 chr6:109599263 A/G cg01475377 chr6:109611718 NA -0.37 -6.54 -0.34 2.41e-10 Reticulocyte fraction of red cells; CRC cis rs35306767 0.714 rs12777800 chr10:1070361 G/A cg26597838 chr10:835615 NA 0.82 9.47 0.46 5.73e-19 Eosinophil percentage of granulocytes; CRC cis rs2108622 0.727 rs62106157 chr19:15980448 G/A cg13772218 chr19:15982569 NA 0.48 6.82 0.35 4.37e-11 Circulating phylloquinone levels;Vitamin E levels;Acenocoumarol maintenance dosage;Response to Vitamin E supplementation;Metabolite levels;Warfarin maintenance dose; CRC cis rs6460942 1.000 rs118083671 chr7:12466036 C/T cg06484146 chr7:12443880 VWDE -0.78 -8.1 -0.41 1.11e-14 Coronary artery disease; CRC cis rs17270561 0.636 rs1165157 chr6:25792250 A/G cg16482183 chr6:26056742 HIST1H1C 0.6 8.12 0.41 9.28e-15 Iron status biomarkers; CRC cis rs1008375 1.000 rs10939750 chr4:17692422 C/G cg16339924 chr4:17578868 LAP3 0.48 6.48 0.34 3.39e-10 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs2070488 0.775 rs2051213 chr3:38560254 C/T cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.75 12.44 0.57 2.13e-29 Electrocardiographic conduction measures; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg10833826 chr17:76837038 USP36 0.38 6.39 0.33 5.75e-10 Liver disease severity in Alagille syndrome; CRC trans rs637571 0.522 rs550435 chr11:65732651 G/A cg17712092 chr4:129076599 LARP1B 0.64 10.33 0.49 7.39e-22 Eosinophil percentage of white cells; CRC cis rs875971 0.964 rs2277911 chr7:65958625 T/G cg00343986 chr7:65444356 GUSB 0.44 6.39 0.33 5.77e-10 Aortic root size; CRC cis rs270601 0.770 rs10463891 chr5:131597392 C/T cg22638593 chr5:131593259 PDLIM4 -0.51 -9.63 -0.47 1.65e-19 Acylcarnitine levels; CRC cis rs4737010 1.000 rs4737010 chr8:41630447 G/A cg17182837 chr8:41585554 ANK1 0.5 6.76 0.35 6.19e-11 Lymphocyte counts;High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Reticulocyte count;Reticulocyte fraction of red cells;Mean corpuscular volume;Immature fraction of reticulocytes;Mean corpuscular hemoglobin concentration; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg23946709 chr14:23527317 CDH24 0.37 6.03 0.32 4.51e-9 Liver disease severity in Alagille syndrome; CRC trans rs561341 1.000 rs15654 chr17:30326360 A/C cg20587970 chr11:113659929 NA -1.43 -20.38 -0.75 2.82e-60 Hip circumference adjusted for BMI; CRC cis rs7833986 0.501 rs2976018 chr8:57014752 G/A cg23139584 chr8:56987506 RPS20;SNORD54 0.91 12.38 0.56 3.79e-29 Height; CRC cis rs66486766 1 rs66486766 chr15:84806060 G/A cg03959625 chr15:84868606 LOC388152 0.4 5.78 0.3 1.74e-8 Bipolar disorder lithium response (categorical) or schizophrenia; CRC cis rs6424115 0.708 rs2076343 chr1:24129126 A/G cg08896387 chr1:24191740 FUCA1 0.54 6.92 0.36 2.35e-11 Immature fraction of reticulocytes; CRC cis rs853679 0.517 rs17711344 chr6:28077602 A/G cg06470822 chr6:28175283 NA -1.05 -14.24 -0.62 3.6e-36 Depression; CRC trans rs6500957 0.920 rs17648524 chr16:7459683 C/G cg25433682 chr16:30407049 ZNF48 0.43 6.2 0.32 1.73e-9 Spherical equivalent (joint analysis main effects and education interaction); CRC trans rs8002861 0.935 rs1822969 chr13:44418164 G/A cg17145862 chr1:211918768 LPGAT1 0.75 15.17 0.64 9.02e-40 Leprosy; CRC cis rs2836974 0.644 rs2836981 chr21:40688365 C/T cg11890956 chr21:40555474 PSMG1 -0.82 -13.11 -0.59 6.96e-32 Cognitive function; CRC cis rs910187 0.532 rs6066209 chr20:45762795 G/T cg27589058 chr20:45804311 EYA2 -0.36 -6.6 -0.34 1.68e-10 Migraine; CRC cis rs3824867 0.879 rs10769267 chr11:47460098 C/T cg05585544 chr11:47624801 NA -0.4 -6.35 -0.33 7.06e-10 Mean corpuscular hemoglobin; CRC trans rs2303319 0.504 rs12467279 chr2:162544744 A/G cg03757145 chr4:76555832 CDKL2 -0.66 -5.97 -0.31 5.99e-9 Cognitive function; CRC cis rs6502050 0.731 rs9892653 chr17:80100191 G/T cg13198984 chr17:80129470 CCDC57 0.46 8.16 0.41 6.94e-15 Life satisfaction; CRC cis rs17270561 0.609 rs9379783 chr6:25725207 C/T cg16482183 chr6:26056742 HIST1H1C 0.73 9.36 0.46 1.33e-18 Iron status biomarkers; CRC cis rs2396545 0.680 rs35467761 chr11:571568 A/G cg16486109 chr11:613632 IRF7 0.68 10.82 0.51 1.46e-23 Systemic lupus erythematosus and Systemic sclerosis; CRC cis rs870825 0.929 rs72689266 chr4:185591053 T/C cg04058563 chr4:185651563 MLF1IP 0.56 5.89 0.31 9.54e-9 Blood protein levels; CRC cis rs8060686 0.920 rs111315946 chr16:67889793 G/C cg26727032 chr16:67993705 SLC12A4 -0.57 -6.95 -0.36 1.94e-11 HDL cholesterol;Metabolic syndrome; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg11810498 chr9:130477698 PTRH1;TTC16 0.5 6.99 0.36 1.49e-11 Response to antipsychotic treatment; CRC cis rs2346160 0.899 rs206980 chr6:167691798 A/G cg04673565 chr6:167680447 NA 0.36 5.8 0.3 1.53e-8 Parental extreme longevity (95 years and older); CRC cis rs1218582 0.741 rs10908447 chr1:154869742 C/T cg24250549 chr1:154909240 PMVK 0.62 9.73 0.47 7.67e-20 Prostate cancer; CRC cis rs10504229 0.679 rs11783444 chr8:58131267 A/G cg05313129 chr8:58192883 C8orf71 -0.43 -6.11 -0.32 2.74e-9 Developmental language disorder (linguistic errors); CRC cis rs11098499 0.697 rs10016448 chr4:120298845 A/G cg24375607 chr4:120327624 NA 0.51 7.86 0.4 5.5e-14 Corneal astigmatism; CRC cis rs7618915 0.547 rs2878726 chr3:52748271 C/G cg08222913 chr3:52553049 STAB1 -0.33 -6.02 -0.31 4.78e-9 Bipolar disorder; CRC cis rs12368653 0.591 rs1038914 chr12:58011066 G/A cg00700412 chr12:58011837 NA -0.42 -6.6 -0.34 1.66e-10 Multiple sclerosis; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg07355551 chr20:2489285 ZNF343 0.52 7.54 0.38 4.54e-13 Response to antipsychotic treatment; CRC cis rs1475911 1.000 rs1475911 chr21:43513480 A/C cg24372256 chr21:43528868 UMODL1;C21orf128 -0.55 -7.43 -0.38 9.62e-13 IgG glycosylation; CRC cis rs9908102 0.740 rs59287437 chr17:12912727 C/G cg26162695 chr17:12921313 ELAC2 0.43 5.85 0.31 1.17e-8 Schizophrenia; CRC cis rs6840360 0.593 rs2175409 chr4:152701656 A/G cg09659197 chr4:152720779 NA 0.4 8.32 0.42 2.29e-15 Intelligence (multi-trait analysis); CRC cis rs7412746 0.611 rs10888394 chr1:150749913 C/T cg18016565 chr1:150552671 MCL1 0.43 5.95 0.31 6.7e-9 Melanoma; CRC cis rs863345 0.504 rs2022386 chr1:158563076 G/A cg12129480 chr1:158549410 OR10X1 -0.34 -7.17 -0.37 4.96e-12 Pneumococcal bacteremia; CRC cis rs6582630 0.539 rs4882324 chr12:38499180 T/C cg26384229 chr12:38710491 ALG10B -0.54 -7.74 -0.39 1.25e-13 Drug-induced liver injury (flucloxacillin); CRC cis rs4926298 0.926 rs8111617 chr19:13191461 C/T cg11738485 chr19:12877000 HOOK2 -0.44 -6.07 -0.32 3.59e-9 Bipolar disorder; CRC cis rs9322193 0.961 rs9767713 chr6:149909377 T/G cg05861140 chr6:150128134 PCMT1 -0.38 -5.9 -0.31 9.25e-9 Lung cancer; CRC cis rs524281 0.861 rs10896085 chr11:65913832 A/T cg16950941 chr11:66035639 RAB1B -0.61 -7.5 -0.38 5.99e-13 Electroencephalogram traits; CRC cis rs6951245 0.744 rs10265736 chr7:1172465 C/T cg20603222 chr7:1096387 C7orf50;GPR146 -0.63 -7.87 -0.4 5.23e-14 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs1799949 0.930 rs3765640 chr17:41276247 A/G cg23758822 chr17:41437982 NA 0.79 13.46 0.6 3.47e-33 Menopause (age at onset); CRC cis rs453301 0.624 rs6987558 chr8:8862521 C/G cg06636001 chr8:8085503 FLJ10661 0.49 7.09 0.36 8.26e-12 Joint mobility (Beighton score); CRC cis rs8072100 0.935 rs12943464 chr17:45690351 A/T cg25173405 chr17:45401733 C17orf57 0.43 6.58 0.34 1.88e-10 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs10504229 0.610 rs6999661 chr8:58127391 C/G cg02290350 chr8:58132656 NA -0.58 -8.16 -0.41 7.29e-15 Developmental language disorder (linguistic errors); CRC cis rs4665809 1.000 rs4665308 chr2:26330514 C/A cg27170947 chr2:26402098 FAM59B -0.46 -6.1 -0.32 2.93e-9 Gut microbiome composition (summer); CRC trans rs3858526 0.959 rs4559671 chr11:5923419 C/T cg01505111 chr6:125621795 HDDC2 0.39 6.23 0.32 1.4e-9 DNA methylation (variation); CRC cis rs4285028 0.747 rs77570895 chr3:121384565 C/T cg20356878 chr3:121714668 ILDR1 -0.46 -6.13 -0.32 2.48e-9 Multiple sclerosis; CRC cis rs2832191 0.646 rs2832210 chr21:30508723 T/G cg08807101 chr21:30365312 RNF160 -0.53 -7.35 -0.38 1.59e-12 Dental caries; CRC cis rs9649213 0.593 rs35535338 chr7:97962319 C/T cg00277769 chr7:97922759 BAIAP2L1 -0.61 -10.65 -0.51 5.74e-23 Prostate cancer (SNP x SNP interaction); CRC cis rs9611565 0.512 rs768414 chr22:42135751 T/C cg06481639 chr22:41940642 POLR3H 0.55 6.19 0.32 1.82e-9 Vitiligo; CRC cis rs11122272 0.675 rs1416913 chr1:231533206 A/C cg06096015 chr1:231504339 EGLN1 0.4 6.0 0.31 5.13e-9 Hemoglobin concentration; CRC cis rs9894429 0.966 rs6565601 chr17:79580173 C/T cg13777783 chr17:79615861 NA -0.3 -5.72 -0.3 2.44e-8 Eye color traits; CRC cis rs1799949 0.965 rs12950779 chr17:41306523 C/T cg25072359 chr17:41440525 NA 0.46 7.0 0.36 1.42e-11 Menopause (age at onset); CRC cis rs2361718 0.967 rs2361719 chr17:78103403 A/G cg21238619 chr17:78079768 GAA 0.32 6.19 0.32 1.76e-9 Yeast infection; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg24849812 chr5:95998671 CAST 0.4 6.2 0.32 1.66e-9 Liver disease severity in Alagille syndrome; CRC trans rs1997103 1.000 rs6945937 chr7:55407140 C/T cg20935933 chr6:143382018 AIG1 0.51 6.65 0.34 1.25e-10 QRS interval (sulfonylurea treatment interaction); CRC cis rs6762 0.719 rs28620453 chr11:836971 G/C cg16425592 chr11:842748 TSPAN4;POLR2L -0.55 -8.22 -0.41 4.88e-15 Mean platelet volume; CRC cis rs7223966 1.000 rs2854223 chr17:61939014 A/G cg23903597 chr17:61704154 MAP3K3 -0.45 -6.22 -0.32 1.48e-9 Hip circumference adjusted for BMI;Body mass index; CRC cis rs2985684 1.000 rs1957977 chr14:50090603 A/G cg10008539 chr14:50087325 RPL36AL;MGAT2 -0.45 -6.1 -0.32 3.02e-9 Carotid intima media thickness; CRC cis rs5758511 0.680 rs5758698 chr22:42684818 C/T cg00645731 chr22:42541494 CYP2D7P1 0.62 9.48 0.46 5.3e-19 Birth weight; CRC cis rs853679 0.517 rs9357065 chr6:28129580 T/C cg23161317 chr6:28129485 ZNF389 0.54 6.47 0.34 3.59e-10 Depression; CRC cis rs1799949 1.000 rs11656097 chr17:41290613 G/T cg01879757 chr17:41196368 BRCA1 -0.44 -6.67 -0.35 1.06e-10 Menopause (age at onset); CRC cis rs8077889 0.871 rs8081101 chr17:41904332 C/T cg25876840 chr17:41920477 NA 0.53 7.92 0.4 3.77e-14 Triglycerides; CRC cis rs7119 0.717 rs12916642 chr15:77818426 G/T cg27398640 chr15:77910606 LINGO1 -0.43 -7.47 -0.38 7.13e-13 Type 2 diabetes; CRC cis rs2204008 0.550 rs11495600 chr12:38126654 C/T cg26384229 chr12:38710491 ALG10B 0.69 9.26 0.45 2.81e-18 Bladder cancer; CRC cis rs11190604 1.000 rs10883512 chr10:102308516 A/G cg16342193 chr10:102329863 NA -0.36 -5.99 -0.31 5.62e-9 Palmitoleic acid (16:1n-7) levels; CRC trans rs9545047 0.716 rs8002838 chr13:79995816 G/A cg07061582 chr15:90234082 PEX11A;WDR93 0.41 5.97 0.31 6.15e-9 Schizophrenia; CRC cis rs11679072 1.000 rs7592764 chr2:240448167 A/C cg03276489 chr2:240449683 NA -0.76 -8.11 -0.41 1.03e-14 Blood pressure (smoking interaction); CRC cis rs875971 0.522 rs1917563 chr7:65415647 C/T cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.47 -6.94 -0.36 2.12e-11 Aortic root size; CRC trans rs35110281 0.715 rs2838320 chr21:44995037 A/G cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.52 8.71 0.43 1.55e-16 Mean corpuscular volume; CRC cis rs2839186 0.771 rs13046451 chr21:47641373 T/A cg13012494 chr21:47604986 C21orf56 -0.47 -7.3 -0.37 2.2e-12 Testicular germ cell tumor; CRC cis rs17376456 0.877 rs55832164 chr5:93436579 C/T cg21475434 chr5:93447410 FAM172A 0.74 7.61 0.39 3e-13 Diabetic retinopathy; CRC cis rs4713118 0.621 rs4713132 chr6:28034035 A/G cg12172441 chr6:28176163 NA 0.59 7.19 0.37 4.51e-12 Parkinson's disease; CRC cis rs6904897 0.563 rs6569976 chr6:135224753 A/C cg24558204 chr6:135376177 HBS1L 0.39 5.66 0.3 3.37e-8 Mean corpuscular volume;Mean corpuscular hemoglobin; CRC cis rs929354 0.713 rs10085650 chr7:156993413 T/C cg16102536 chr7:156981717 UBE3C 0.4 6.76 0.35 6.39e-11 Body mass index; CRC cis rs561341 0.714 rs75861674 chr17:30304317 A/G cg12193833 chr17:30244370 NA -0.62 -7.98 -0.4 2.46e-14 Hip circumference adjusted for BMI; CRC cis rs10046574 0.519 rs7799873 chr7:135214030 C/T cg27474649 chr7:135195673 CNOT4 0.6 5.88 0.31 1.01e-8 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs6860806 0.507 rs272854 chr5:131688017 C/T cg02033258 chr5:131593261 PDLIM4 0.38 6.36 0.33 6.76e-10 Breast cancer; CRC trans rs11098499 0.874 rs7661020 chr4:120106982 T/C cg25214090 chr10:38739885 LOC399744 0.51 7.57 0.39 3.68e-13 Corneal astigmatism; CRC cis rs10751667 0.643 rs10902244 chr11:949981 A/G cg06064525 chr11:970664 AP2A2 -0.33 -6.76 -0.35 6.25e-11 Alzheimer's disease (late onset); CRC cis rs73206853 0.764 rs3026447 chr12:110724272 C/T cg12870014 chr12:110450643 ANKRD13A 0.66 8.22 0.41 4.85e-15 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC cis rs7605827 0.930 rs2049720 chr2:15514982 T/C cg19274914 chr2:15703543 NA 0.4 6.03 0.32 4.33e-9 Educational attainment (years of education); CRC cis rs1784581 0.588 rs9346893 chr6:162417511 C/G cg17173639 chr6:162384350 PARK2 0.61 9.93 0.48 1.69e-20 Itch intensity from mosquito bite; CRC cis rs4638749 0.773 rs4676190 chr2:108858619 A/G cg25838818 chr2:108905173 SULT1C2 -0.41 -6.1 -0.32 3.04e-9 Blood pressure; CRC cis rs9640161 0.750 rs11765644 chr7:150026339 C/G cg13722127 chr7:150037890 RARRES2 0.52 8.1 0.41 1.09e-14 Blood protein levels;Circulating chemerin levels; CRC trans rs1997103 0.871 rs1997101 chr7:55399652 A/T cg20935933 chr6:143382018 AIG1 0.54 6.96 0.36 1.86e-11 QRS interval (sulfonylurea treatment interaction); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg14526843 chr3:122233584 KPNA1 0.47 6.94 0.36 2.13e-11 Intelligence (multi-trait analysis); CRC cis rs9486719 1.000 rs12207570 chr6:96987884 A/C cg06623918 chr6:96969491 KIAA0776 -0.82 -9.54 -0.47 3.4e-19 Migraine;Coronary artery disease; CRC cis rs10992471 0.603 rs7850528 chr9:95208992 A/G cg14631576 chr9:95140430 CENPP -0.39 -6.84 -0.35 3.86e-11 Visceral adipose tissue/subcutaneous adipose tissue ratio; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg27127705 chr8:56685527 TMEM68;TGS1 0.44 6.13 0.32 2.48e-9 Anxiety disorder; CRC cis rs7901135 0.924 rs4627022 chr10:60563952 T/C cg23799393 chr10:60588674 BICC1 0.37 5.66 0.3 3.22e-8 Morning vs. evening chronotype; CRC cis rs55788414 1.000 rs55788414 chr16:81184939 C/T cg06400318 chr16:81190750 PKD1L2 -0.69 -6.7 -0.35 8.92e-11 Left ventricular obstructive tract defect (maternal effect); CRC cis rs4268898 0.662 rs72793213 chr2:24524725 A/G cg06627628 chr2:24431161 ITSN2 -0.83 -11.62 -0.54 2.25e-26 Asthma; CRC cis rs9372498 0.536 rs9489467 chr6:118935206 C/T cg15382696 chr6:118971807 C6orf204 0.6 7.57 0.39 3.76e-13 Diastolic blood pressure; CRC cis rs9814567 1.000 rs9827987 chr3:134272621 A/G cg06541857 chr3:134203789 ANAPC13;CEP63 -0.4 -5.97 -0.31 6.01e-9 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC trans rs10983614 1.000 rs7867776 chr9:120072627 A/G cg18802567 chr5:171433913 FBXW11 0.45 6.18 0.32 1.92e-9 Survival in pancreatic cancer; CRC trans rs8177876 0.908 rs80187824 chr16:81118680 T/C cg09779152 chr17:73205364 NUP85 0.61 5.99 0.31 5.57e-9 Plasma omega-3 polyunsaturated fatty acid level (eicosapentaenoic acid); CRC cis rs7918232 1.000 rs7918232 chr10:27369162 A/G cg14240646 chr10:27532245 ACBD5 -0.75 -8.6 -0.43 3.29e-16 Breast cancer; CRC cis rs4819052 1.000 rs2297286 chr21:46707897 C/G cg02159808 chr21:46707872 POFUT2;LOC642852 0.66 7.98 0.4 2.46e-14 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs3733585 0.638 rs13145554 chr4:9979589 C/T cg00071950 chr4:10020882 SLC2A9 0.56 9.82 0.48 3.87e-20 Cleft plate (environmental tobacco smoke interaction); CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg05628496 chr17:17991167 DRG2 -0.55 -6.77 -0.35 5.89e-11 Diisocyanate-induced asthma; CRC cis rs2108622 0.683 rs6512067 chr19:15982951 G/T cg13772218 chr19:15982569 NA 0.46 6.71 0.35 8.35e-11 Circulating phylloquinone levels;Vitamin E levels;Acenocoumarol maintenance dosage;Response to Vitamin E supplementation;Metabolite levels;Warfarin maintenance dose; CRC cis rs3785574 0.962 rs2665799 chr17:61919723 A/G cg06873352 chr17:61820015 STRADA 0.5 7.8 0.39 8.51e-14 Height; CRC cis rs13256369 0.851 rs13271698 chr8:8567539 C/A cg06636001 chr8:8085503 FLJ10661 0.49 6.06 0.32 3.69e-9 Obesity-related traits; CRC cis rs897984 0.609 rs4889609 chr16:31026427 A/G cg02466173 chr16:30829666 NA -0.62 -9.21 -0.45 4.02e-18 Dementia with Lewy bodies; CRC cis rs4730250 0.707 rs257373 chr7:106798290 G/A cg02696742 chr7:106810147 HBP1 -0.61 -6.82 -0.35 4.4e-11 Osteoarthritis; CRC cis rs34864796 0.547 rs200476 chr6:27768348 A/T cg25164649 chr6:28176230 NA 0.47 5.63 0.3 3.95e-8 Lung function (FEV1);Lung function (FEV1/FVC);Lung function (FVC); CRC cis rs11971779 0.648 rs28754644 chr7:139065057 C/T cg07862535 chr7:139043722 LUC7L2 0.57 7.35 0.38 1.61e-12 Diisocyanate-induced asthma; CRC cis rs752010 0.756 rs943374 chr1:42056194 A/G cg06885757 chr1:42089581 HIVEP3 0.34 5.99 0.31 5.63e-9 Lupus nephritis in systemic lupus erythematosus; CRC cis rs13315871 0.929 rs28659863 chr3:58328072 C/T cg20936604 chr3:58311152 NA -0.75 -7.73 -0.39 1.28e-13 Cholesterol, total; CRC trans rs4363385 0.720 rs1611754 chr1:152956415 A/T cg03800765 chr3:11313984 ATG7 -0.41 -6.06 -0.32 3.73e-9 Inflammatory skin disease; CRC cis rs7731657 0.518 rs7706328 chr5:130218943 G/C cg08523029 chr5:130500466 HINT1 -0.41 -5.63 -0.3 3.87e-8 Fasting plasma glucose; CRC cis rs4664308 1.000 rs925410 chr2:160912652 C/T cg03641300 chr2:160917029 PLA2R1 0.75 12.67 0.57 3.08e-30 Idiopathic membranous nephropathy; CRC cis rs2842126 0.518 rs2813305 chr10:52007969 A/G cg13488930 chr10:51784648 NA -0.43 -5.89 -0.31 9.38e-9 Blood protein levels; CRC cis rs6502050 0.835 rs62078304 chr17:80085224 G/A cg25804541 chr17:80189381 SLC16A3 0.31 6.01 0.31 4.97e-9 Life satisfaction; CRC cis rs9640161 0.830 rs13307276 chr7:150061525 T/C cg13722127 chr7:150037890 RARRES2 0.39 5.63 0.3 3.95e-8 Blood protein levels;Circulating chemerin levels; CRC cis rs28386778 0.704 rs1051688 chr17:62006433 G/C cg25654072 chr17:61904446 PSMC5;FTSJ3 -0.48 -6.93 -0.36 2.26e-11 Prudent dietary pattern; CRC cis rs752010 0.714 rs10890144 chr1:42085397 G/T cg06885757 chr1:42089581 HIVEP3 0.47 8.53 0.43 5.38e-16 Lupus nephritis in systemic lupus erythematosus; CRC trans rs6956675 1.000 rs4718791 chr7:62577991 G/C cg01314568 chr7:57830625 NA -0.68 -9.35 -0.46 1.39e-18 Obesity-related traits; CRC cis rs7258465 0.931 rs875396 chr19:18611147 A/G cg06462663 chr19:18546047 ISYNA1 0.46 7.04 0.36 1.15e-11 Breast cancer; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg18159230 chr1:169076004 ATP1B1 0.39 6.37 0.33 6.39e-10 Liver disease severity in Alagille syndrome; CRC cis rs6952808 0.929 rs12532128 chr7:1925454 T/C cg21782813 chr7:2030301 MAD1L1 0.46 7.96 0.4 2.9e-14 Bipolar disorder and schizophrenia; CRC cis rs7725052 0.609 rs6872742 chr5:40470086 C/T cg09067459 chr5:40385259 NA 0.43 7.11 0.36 7.43e-12 Pediatric autoimmune diseases; CRC cis rs17095355 1.000 rs9988702 chr10:111703389 G/A cg00817464 chr10:111662876 XPNPEP1 -0.6 -8.02 -0.4 1.84e-14 Biliary atresia; CRC trans rs7619427 0.544 rs9821661 chr3:44031551 G/A cg09408571 chr1:101003634 GPR88 0.45 6.25 0.33 1.24e-9 Schizophrenia; CRC cis rs60871478 0.636 rs10245785 chr7:894422 T/C cg13844804 chr7:814759 HEATR2 -0.55 -5.87 -0.31 1.06e-8 Cerebrospinal P-tau181p levels; CRC cis rs1129187 0.967 rs6941212 chr6:42915920 A/G cg09436375 chr6:42928200 GNMT -0.31 -5.8 -0.3 1.55e-8 Alzheimer's disease in APOE e4+ carriers; CRC cis rs3825932 1.000 rs3825932 chr15:79235446 A/G cg25744700 chr15:79237217 CTSH 0.39 6.04 0.32 4.13e-9 Type 1 diabetes; CRC cis rs10254118 0.757 rs13241123 chr7:133135507 A/T cg10665199 chr7:133106180 EXOC4 0.65 9.75 0.47 6.76e-20 Intelligence (multi-trait analysis); CRC trans rs7395662 0.895 rs4882238 chr11:48755540 A/G cg21153622 chr11:89784906 NA -0.48 -7.79 -0.39 8.59e-14 HDL cholesterol; CRC cis rs11608355 0.515 rs11609630 chr12:109918934 C/T cg05360138 chr12:110035743 NA 0.78 8.76 0.43 1.07e-16 Neuroticism; CRC trans rs1814175 0.781 rs2866734 chr11:49886338 A/G cg21153622 chr11:89784906 NA -0.38 -6.04 -0.32 4.27e-9 Height; CRC cis rs644799 0.648 rs1255182 chr11:95472391 C/T cg25622487 chr11:95524042 FAM76B;CEP57 0.51 7.56 0.38 3.99e-13 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs13191362 0.810 rs13209784 chr6:162961274 T/C cg21926612 chr6:163149169 PACRG;PARK2 0.82 10.35 0.5 6.61e-22 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs13191362 1.000 rs35593345 chr6:163174981 G/C cg14584255 chr6:163149320 PACRG;PARK2 0.4 5.62 0.3 4e-8 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs12926788 0.640 rs73551577 chr16:24845143 G/A cg00339695 chr16:24857497 SLC5A11 0.41 8.56 0.43 4.41e-16 Ejection fraction in Tripanosoma cruzi seropositivity; CRC cis rs17345786 0.511 rs13061565 chr3:101392270 T/C cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.62 8.41 0.42 1.3e-15 Colonoscopy-negative controls vs population controls; CRC cis rs7264396 0.563 rs6060570 chr20:34291166 A/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.49 -6.97 -0.36 1.7e-11 Total cholesterol levels; CRC cis rs210142 1.000 rs210142 chr6:33546837 T/C cg24505687 chr6:33548425 BAK1 0.4 6.74 0.35 6.98e-11 Platelet count;Plateletcrit;Chronic lymphocytic leukemia; CRC cis rs7932354 0.583 rs2306026 chr11:46889713 T/C cg19486271 chr11:47235900 DDB2 -0.42 -6.34 -0.33 7.49e-10 Bone mineral density (hip);Bone mineral density; CRC cis rs7264396 0.563 rs2225950 chr20:34333015 C/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.47 -6.43 -0.33 4.46e-10 Total cholesterol levels; CRC cis rs2257205 0.667 rs9909763 chr17:56629640 C/T cg25885038 chr17:56607967 SEPT4 -0.54 -6.17 -0.32 1.99e-9 Pancreatic cancer; CRC cis rs2404602 0.647 rs118129828 chr15:77015200 T/C cg03037974 chr15:76606532 NA -0.56 -8.51 -0.42 6.38e-16 Blood metabolite levels; CRC cis rs9341808 0.935 rs2298307 chr6:80816296 A/G cg08355045 chr6:80787529 NA 0.37 6.25 0.33 1.26e-9 Sitting height ratio; CRC cis rs10883723 0.810 rs7090276 chr10:104281239 G/T cg22532475 chr10:104410764 TRIM8 -0.36 -6.79 -0.35 5.16e-11 Allergic disease (asthma, hay fever or eczema); CRC cis rs60871478 0.588 rs73043546 chr7:857513 C/G cg13798912 chr7:905769 UNC84A -0.62 -6.36 -0.33 6.71e-10 Cerebrospinal P-tau181p levels; CRC cis rs11677370 0.533 rs12711971 chr2:3820821 G/C cg17052675 chr2:3827356 NA -0.66 -11.47 -0.53 7.74e-26 Type 2 diabetes; CRC cis rs11711311 0.712 rs10804510 chr3:113340700 T/A cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.54 -7.18 -0.37 4.57e-12 IgG glycosylation; CRC cis rs1552244 0.810 rs4019706 chr3:10112862 G/A cg13047869 chr3:10149882 C3orf24 0.53 7.31 0.37 2.04e-12 Alzheimer's disease; CRC cis rs17095355 1.000 rs12242642 chr10:111724213 G/A cg00817464 chr10:111662876 XPNPEP1 -0.63 -8.56 -0.43 4.5e-16 Biliary atresia; CRC trans rs4263408 0.934 rs9683743 chr4:39703194 A/C cg18719198 chr14:55369460 GCH1 -0.44 -6.5 -0.34 2.91e-10 Plasma amyloid beta peptide concentrations (ABx-40); CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg12417590 chr20:42086612 SFRS6 0.47 7.96 0.4 2.79e-14 Obesity-related traits; CRC cis rs477895 0.653 rs12797120 chr11:63906819 C/T cg04317338 chr11:64019027 PLCB3 0.6 7.28 0.37 2.53e-12 Mean platelet volume; CRC cis rs8060686 0.565 rs36046686 chr16:68122269 T/C cg26727032 chr16:67993705 SLC12A4 -0.57 -6.59 -0.34 1.72e-10 HDL cholesterol;Metabolic syndrome; CRC trans rs1814175 0.616 rs10839388 chr11:49842603 C/T cg03929089 chr4:120376271 NA -0.89 -15.31 -0.65 2.45e-40 Height; CRC cis rs7274811 0.681 rs291707 chr20:31964256 G/A cg07470512 chr20:32255052 NECAB3;C20orf134 0.45 6.17 0.32 1.95e-9 Height; CRC cis rs17384381 0.734 rs12129013 chr1:85891709 A/C cg16011679 chr1:85725395 C1orf52 0.49 6.29 0.33 1.03e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs7208859 0.623 rs11650973 chr17:29214045 G/A cg13385521 chr17:29058706 SUZ12P 0.64 7.72 0.39 1.39e-13 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs9420 1.000 rs9420 chr11:57510294 A/G cg23127183 chr11:57508653 C11orf31 0.53 7.41 0.38 1.09e-12 Schizophrenia; CRC cis rs13118159 0.771 rs13117476 chr4:1334721 A/G cg21620606 chr4:1342894 KIAA1530 0.53 9.59 0.47 2.32e-19 Longevity; CRC cis rs10886503 0.920 rs3009907 chr10:121262454 G/T cg17804342 chr10:121271663 RGS10 -0.82 -7.77 -0.39 1.03e-13 Obstetric antiphospholipid syndrome; CRC cis rs780096 0.546 rs7563162 chr2:27631191 C/T cg02592271 chr2:27665507 KRTCAP3 -0.27 -6.17 -0.32 1.97e-9 Total body bone mineral density; CRC trans rs208520 0.802 rs1342959 chr6:66883329 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.91 -12.38 -0.56 3.59e-29 Exhaled nitric oxide output; CRC cis rs2073499 0.935 rs57838764 chr3:50374568 T/C cg08207895 chr3:50388901 TUSC4;CYB561D2 0.58 6.36 0.33 6.73e-10 Schizophrenia; CRC cis rs10256972 0.552 rs2960831 chr7:1201192 A/T cg04025307 chr7:1156635 C7orf50 0.62 9.74 0.47 7.5e-20 Longevity;Endometriosis; CRC cis rs6831352 1.000 rs1126671 chr4:100048414 T/C cg12011299 chr4:100065546 ADH4 0.53 10.92 0.52 6.76e-24 Alcohol dependence; CRC cis rs9329289 0.510 rs9733402 chr10:2551532 G/A cg15501526 chr10:2543763 NA 0.5 8.99 0.44 1.97e-17 Age-related hearing impairment; CRC cis rs2243480 1.000 rs387676 chr7:65598220 C/T cg25985355 chr7:65971099 NA -0.51 -5.87 -0.31 1.05e-8 Diabetic kidney disease; CRC cis rs2153535 0.505 rs1335629 chr6:8491863 C/T cg07606381 chr6:8435919 SLC35B3 0.67 10.69 0.51 4.33e-23 Motion sickness; CRC cis rs62458065 0.513 rs787216 chr7:32578891 G/A cg20159608 chr7:32802032 NA -0.62 -8.01 -0.4 2.04e-14 Metabolite levels (HVA/MHPG ratio); CRC cis rs4713118 0.662 rs9393881 chr6:28023751 C/G cg12273811 chr6:28175739 NA 0.61 8.16 0.41 7.15e-15 Parkinson's disease; CRC cis rs9928842 0.882 rs9319481 chr16:75259478 T/C cg08657710 chr16:75258780 CTRB1 -0.55 -6.35 -0.33 7.27e-10 Alcoholic chronic pancreatitis; CRC cis rs12410462 0.681 rs79461024 chr1:227568783 G/T cg04117972 chr1:227635322 NA 0.64 5.75 0.3 2.07e-8 Major depressive disorder; CRC cis rs2735413 0.875 rs4888737 chr16:78083819 A/G cg04733911 chr16:78082701 NA -0.45 -7.54 -0.38 4.5e-13 Systolic blood pressure (alcohol consumption interaction); CRC trans rs11225569 0.539 rs7932706 chr11:103340376 A/T cg01615333 chr12:127765195 NA -0.64 -6.03 -0.32 4.37e-9 Diisocyanate-induced asthma; CRC cis rs898097 0.841 rs8180 chr17:80901036 C/G cg16060761 chr17:80687452 NA -0.41 -5.9 -0.31 8.96e-9 Breast cancer; CRC cis rs853679 0.517 rs3173443 chr6:28137027 T/G cg06470822 chr6:28175283 NA 1.03 13.59 0.6 1.04e-33 Depression; CRC trans rs7618501 0.633 rs12485600 chr3:50025530 A/G cg21659725 chr3:3221576 CRBN 0.61 9.66 0.47 1.37e-19 Intelligence (multi-trait analysis); CRC trans rs7267979 1.000 rs6037086 chr20:25306338 A/G cg17903999 chr18:56338584 MALT1 0.43 6.85 0.35 3.73e-11 Liver enzyme levels (alkaline phosphatase); CRC cis rs13161895 0.938 rs594202 chr5:179417335 C/T cg02702477 chr5:179499311 RNF130 0.55 6.4 0.33 5.21e-10 LDL cholesterol; CRC cis rs294883 0.858 rs9457583 chr6:159722182 A/G cg14500486 chr6:159655392 FNDC1 0.35 5.83 0.31 1.36e-8 Coronary artery disease; CRC cis rs28386778 0.897 rs9913323 chr17:61851485 C/A cg11494091 chr17:61959527 GH2 0.59 10.1 0.49 4.39e-21 Prudent dietary pattern; CRC cis rs10504229 0.593 rs78459635 chr8:58004995 G/T cg02290350 chr8:58132656 NA -0.5 -5.71 -0.3 2.54e-8 Developmental language disorder (linguistic errors); CRC cis rs9733 0.596 rs12086472 chr1:150697710 G/A cg15448220 chr1:150897856 SETDB1 0.45 6.41 0.33 5.09e-10 Tonsillectomy; CRC cis rs6570726 0.935 rs454614 chr6:145832633 C/T cg05347473 chr6:146136440 FBXO30 0.37 6.0 0.31 5.27e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs6732160 0.932 rs768851 chr2:73378241 G/A cg01422370 chr2:73384389 NA 0.33 5.67 0.3 3.17e-8 Intelligence (multi-trait analysis); CRC cis rs6952808 0.692 rs60755037 chr7:2030104 G/A cg04267008 chr7:1944627 MAD1L1 -0.78 -11.33 -0.53 2.45e-25 Bipolar disorder and schizophrenia; CRC cis rs1448094 0.511 rs61930587 chr12:86158793 T/C cg18827107 chr12:86230957 RASSF9 -0.4 -6.08 -0.32 3.39e-9 Major depressive disorder; CRC cis rs9309711 0.666 rs4321399 chr2:3481659 G/A cg15541040 chr2:3486749 NA -0.48 -7.58 -0.39 3.5e-13 Neurofibrillary tangles; CRC cis rs7703744 0.681 rs17145294 chr5:118701433 G/T cg02283238 chr5:118691126 TNFAIP8 0.46 6.27 0.33 1.12e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs10504229 0.861 rs67042991 chr8:58191749 G/C cg02290350 chr8:58132656 NA -0.42 -5.96 -0.31 6.62e-9 Developmental language disorder (linguistic errors); CRC cis rs8060686 0.641 rs12448677 chr16:68209741 G/A cg08314208 chr16:67682810 RLTPR -0.54 -5.94 -0.31 7.18e-9 HDL cholesterol;Metabolic syndrome; CRC cis rs2836974 0.966 rs7283516 chr21:40690537 A/G cg06238570 chr21:40685208 BRWD1 0.75 10.23 0.49 1.63e-21 Cognitive function; CRC cis rs2204008 0.775 rs8186812 chr12:38305055 C/T cg13010199 chr12:38710504 ALG10B 0.47 6.37 0.33 6.31e-10 Bladder cancer; CRC cis rs7487075 0.823 rs34472481 chr12:46836348 C/G cg17501823 chr12:47219793 SLC38A4 0.32 5.94 0.31 7.11e-9 Itch intensity from mosquito bite; CRC cis rs3820068 0.553 rs7545782 chr1:15955227 G/C cg24675056 chr1:15929824 NA 0.49 6.83 0.35 4.15e-11 Systolic blood pressure; CRC cis rs875971 0.545 rs7787063 chr7:65628999 G/A cg11764359 chr7:65958608 NA 0.47 5.9 0.31 8.88e-9 Aortic root size; CRC cis rs375066 0.592 rs349045 chr19:44299892 A/G cg11993925 chr19:44307056 LYPD5 -0.37 -6.16 -0.32 2.18e-9 Breast cancer; CRC cis rs911119 1.000 rs67567111 chr20:23619075 G/T cg16589663 chr20:23618590 CST3 0.62 8.01 0.4 2.01e-14 Chronic kidney disease; CRC cis rs344364 0.511 rs2982449 chr16:1947878 C/G cg14074117 chr16:1909714 C16orf73 0.41 5.66 0.3 3.28e-8 Glomerular filtration rate in chronic kidney disease; CRC cis rs7799006 0.929 rs35629140 chr7:2257171 G/C cg08027265 chr7:2291960 NA -0.41 -6.25 -0.33 1.24e-9 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs35110281 0.627 rs56369437 chr21:44970275 A/G cg04455712 chr21:45112962 RRP1B 0.38 7.22 0.37 3.72e-12 Mean corpuscular volume; CRC cis rs877282 0.945 rs17293517 chr10:778770 C/T cg17470449 chr10:769945 NA 0.66 8.69 0.43 1.74e-16 Uric acid levels; CRC cis rs9768139 0.708 rs896781 chr7:158114114 T/C cg24154853 chr7:158122151 PTPRN2 0.58 9.62 0.47 1.76e-19 Calcium levels; CRC cis rs9649213 0.593 rs6465683 chr7:98026092 C/A cg21770322 chr7:97807741 LMTK2 0.53 8.6 0.43 3.35e-16 Prostate cancer (SNP x SNP interaction); CRC cis rs9372498 0.536 rs9489477 chr6:118946192 T/G cg18833306 chr6:118973337 C6orf204 0.45 5.81 0.3 1.49e-8 Diastolic blood pressure; CRC cis rs9467711 0.606 rs9379875 chr6:26444732 C/T cg08501292 chr6:25962987 TRIM38 0.83 6.43 0.33 4.44e-10 Autism spectrum disorder or schizophrenia; CRC cis rs7512552 0.809 rs1694363 chr1:150368677 T/G cg15654264 chr1:150340011 RPRD2 0.58 7.84 0.4 6.3e-14 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); CRC cis rs7258465 1.000 rs2303697 chr19:18546678 T/C cg06953865 chr19:18549723 ISYNA1 -0.39 -5.77 -0.3 1.81e-8 Breast cancer; CRC trans rs61931739 0.517 rs11053067 chr12:34191391 T/C cg26384229 chr12:38710491 ALG10B 0.54 6.88 0.35 2.99e-11 Morning vs. evening chronotype; CRC cis rs1552244 0.572 rs57268864 chr3:10164233 C/A cg16606324 chr3:10149918 C3orf24 0.66 7.74 0.39 1.19e-13 Alzheimer's disease; CRC cis rs7215564 0.908 rs34384177 chr17:78667040 A/T cg09596252 chr17:78655493 RPTOR 0.55 6.09 0.32 3.19e-9 Myopia (pathological); CRC cis rs6952808 0.609 rs12699453 chr7:1953056 C/T cg02951883 chr7:2050386 MAD1L1 -0.55 -9.08 -0.45 1.03e-17 Bipolar disorder and schizophrenia; CRC cis rs8180040 0.967 rs17411375 chr3:47395135 C/T cg27129171 chr3:47204927 SETD2 -0.65 -10.34 -0.5 6.98e-22 Colorectal cancer; CRC cis rs6502050 0.835 rs9904520 chr17:80100117 T/C cg09264619 chr17:80180166 NA -0.34 -5.81 -0.3 1.5e-8 Life satisfaction; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg01711073 chr1:37980396 MEAF6 0.41 6.18 0.32 1.89e-9 Response to antipsychotic treatment; CRC cis rs4363385 0.588 rs6660878 chr1:153027068 A/G cg25856811 chr1:152973957 SPRR3 -0.24 -6.52 -0.34 2.59e-10 Inflammatory skin disease; CRC cis rs7726839 0.574 rs11134148 chr5:637107 C/T cg16447950 chr5:562315 NA -0.74 -9.76 -0.47 6.14e-20 Obesity-related traits; CRC cis rs3849570 0.555 rs4481177 chr3:81996817 A/T cg07356753 chr3:81810745 GBE1 0.51 7.08 0.36 8.94e-12 Waist circumference;Body mass index; CRC cis rs4731207 0.646 rs7783781 chr7:124454413 T/G cg23710748 chr7:124431027 NA 0.38 6.08 0.32 3.42e-9 Cutaneous malignant melanoma; CRC cis rs4927850 0.881 rs7624638 chr3:195748729 C/T cg00031303 chr3:195681400 NA 0.5 7.19 0.37 4.45e-12 Pancreatic cancer; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg11342046 chr2:242641489 ING5 0.47 6.76 0.35 6.43e-11 Response to antipsychotic treatment; CRC cis rs1532331 0.898 rs6876746 chr5:43173085 A/T cg09164108 chr5:43007320 NA 0.38 5.79 0.3 1.63e-8 Menarche (age at onset); CRC cis rs4474465 0.688 rs7942527 chr11:78280322 A/G cg27205649 chr11:78285834 NARS2 0.54 7.1 0.36 7.95e-12 Alzheimer's disease (survival time); CRC cis rs7618915 0.547 rs12496476 chr3:52708737 A/G cg15147215 chr3:52552868 STAB1 -0.62 -10.31 -0.49 8.76e-22 Bipolar disorder; CRC cis rs12188164 0.561 rs2721010 chr5:456915 A/G cg14122633 chr5:456516 EXOC3 -0.4 -7.1 -0.36 7.82e-12 Cystic fibrosis severity; CRC cis rs11098499 0.697 rs28655325 chr4:120372999 A/G cg24375607 chr4:120327624 NA 0.51 7.98 0.4 2.49e-14 Corneal astigmatism; CRC cis rs6951245 1.000 rs78861357 chr7:1095418 C/T cg03188948 chr7:1209495 NA 0.66 6.94 0.36 2.04e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC trans rs11088226 0.581 rs2833856 chr21:33877691 A/G cg09050820 chr6:167586206 TCP10L2 -0.58 -8.03 -0.4 1.76e-14 Gastritis; CRC cis rs4665809 1.000 rs4665819 chr2:26309073 A/G cg25036284 chr2:26402008 FAM59B -0.46 -6.03 -0.32 4.3e-9 Gut microbiome composition (summer); CRC cis rs7647973 1.000 rs3448 chr3:49396751 T/C cg07636037 chr3:49044803 WDR6 0.65 7.81 0.4 7.8e-14 Menarche (age at onset); CRC cis rs4819052 1.000 rs13052356 chr21:46663588 G/A cg19498844 chr21:46707878 POFUT2;LOC642852 0.84 11.18 0.52 7.89e-25 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs9368481 0.524 rs12530345 chr6:26884243 T/C cg12292205 chr6:26970375 C6orf41 0.61 9.59 0.47 2.34e-19 Autism spectrum disorder or schizophrenia; CRC cis rs2836974 0.865 rs34778912 chr21:40667037 T/G cg06238570 chr21:40685208 BRWD1 0.79 10.97 0.52 4.45e-24 Cognitive function; CRC cis rs10504229 0.683 rs17194995 chr8:58109220 A/C cg22535103 chr8:58192502 C8orf71 0.69 7.79 0.39 8.55e-14 Developmental language disorder (linguistic errors); CRC trans rs7604735 0.824 rs6747275 chr2:145819922 A/G cg26010734 chr19:15344046 EPHX3 -0.35 -6.12 -0.32 2.68e-9 Coronary artery disease; CRC cis rs4713118 0.869 rs10214440 chr6:27702440 A/C cg12273811 chr6:28175739 NA 0.56 7.93 0.4 3.5e-14 Parkinson's disease; CRC cis rs8060686 0.925 rs13336189 chr16:67814152 C/A cg26727032 chr16:67993705 SLC12A4 -0.73 -11.36 -0.53 1.83e-25 HDL cholesterol;Metabolic syndrome; CRC trans rs11039798 0.699 rs7120775 chr11:48266736 C/G cg27395922 chr11:50257633 LOC441601 0.48 6.05 0.32 3.87e-9 Axial length; CRC trans rs10242455 0.702 rs73713531 chr7:99222379 C/T cg09045935 chr12:6379348 NA 0.95 7.05 0.36 1.08e-11 Blood metabolite levels; CRC cis rs4975616 1.000 rs4975616 chr5:1315660 G/A cg06550200 chr5:1325588 CLPTM1L 0.63 9.24 0.45 3.04e-18 Lung cancer; CRC cis rs6754459 0.694 rs4404281 chr2:3706055 C/T cg19052272 chr2:3704530 ALLC -0.5 -7.22 -0.37 3.64e-12 Response to inhaled corticosteroid treatment in asthma (change in FEV1); CRC trans rs875971 0.660 rs2191268 chr7:66110224 C/T cg14550653 chr6:52149695 MCM3 -0.36 -5.97 -0.31 6.26e-9 Aortic root size; CRC cis rs8180040 0.903 rs13094438 chr3:47277885 G/A cg02527881 chr3:46936655 PTH1R -0.4 -7.54 -0.38 4.61e-13 Colorectal cancer; CRC cis rs524281 0.773 rs2017969 chr11:66039032 G/A cg16950941 chr11:66035639 RAB1B -0.72 -8.1 -0.41 1.09e-14 Electroencephalogram traits; CRC cis rs3892630 0.588 rs1976501 chr19:33208155 C/T cg22980127 chr19:33182716 NUDT19 0.88 11.16 0.52 9.85e-25 Red blood cell traits; CRC cis rs7692995 1.000 rs6853216 chr4:17970655 C/T cg08925142 chr4:18023851 LCORL -0.5 -5.65 -0.3 3.39e-8 Height; CRC cis rs9928842 0.882 rs9927264 chr16:75260241 T/C cg08657710 chr16:75258780 CTRB1 -0.53 -6.12 -0.32 2.72e-9 Alcoholic chronic pancreatitis; CRC cis rs17376456 1.000 rs13181660 chr5:93533658 A/G cg09848695 chr5:92956644 FAM172A;MIR2277 0.69 6.44 0.33 4.13e-10 Diabetic retinopathy; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg26003386 chr19:14116507 RFX1 0.42 6.12 0.32 2.61e-9 Response to antipsychotic treatment; CRC trans rs6598955 0.671 rs11579354 chr1:26604071 T/G cg07461501 chr17:79650226 HGS;ARL16 -0.52 -6.19 -0.32 1.77e-9 Obesity-related traits; CRC trans rs1728785 1.000 rs1645981 chr16:68571648 T/C cg04657470 chr2:198365150 HSPE1;HSPD1 0.58 6.97 0.36 1.72e-11 Ulcerative colitis; CRC cis rs7552404 0.731 rs5745445 chr1:76344332 G/A cg22875332 chr1:76189707 ACADM 0.63 7.63 0.39 2.59e-13 Blood metabolite levels;Acylcarnitine levels; CRC cis rs3806843 1.000 rs2337985 chr5:140157861 T/C cg19875535 chr5:140030758 IK 0.6 9.79 0.47 5.14e-20 Depressive symptoms (multi-trait analysis); CRC cis rs2033908 0.558 rs6486064 chr11:12869509 T/C cg25843174 chr11:12811716 TEAD1 -0.39 -6.84 -0.35 3.9e-11 Sitting height ratio; CRC cis rs7589728 1.000 rs75181745 chr2:88520408 C/T cg18490616 chr2:88469792 THNSL2 0.57 5.71 0.3 2.46e-8 Plasma clusterin levels; CRC cis rs853679 0.599 rs202906 chr6:28011652 C/T cg15845792 chr6:28175446 NA -0.73 -6.99 -0.36 1.5e-11 Depression; CRC cis rs477692 0.905 rs524545 chr10:131411840 A/C cg05714579 chr10:131428358 MGMT -0.56 -8.01 -0.4 1.94e-14 Response to temozolomide; CRC cis rs2952156 0.920 rs8078228 chr17:37834998 C/T cg00129232 chr17:37814104 STARD3 -0.68 -12.01 -0.55 8.36e-28 Asthma; CRC cis rs7677751 0.806 rs1800813 chr4:55094467 G/A cg00691999 chr4:55094011 PDGFRA 0.43 5.91 0.31 8.51e-9 Corneal astigmatism; CRC cis rs8060686 0.641 rs8047119 chr16:68047345 G/C cg08314208 chr16:67682810 RLTPR -0.65 -6.8 -0.35 4.91e-11 HDL cholesterol;Metabolic syndrome; CRC cis rs2898681 0.521 rs115874483 chr4:53728272 G/A cg00338735 chr4:53728038 RASL11B 0.48 6.51 0.34 2.8e-10 Optic nerve measurement (cup area); CRC cis rs4665809 0.549 rs17527979 chr2:26428132 A/G cg27170947 chr2:26402098 FAM59B -0.64 -7.76 -0.39 1.1e-13 Gut microbiome composition (summer); CRC cis rs769267 0.965 rs2074299 chr19:19380646 T/C cg01262667 chr19:19385393 TM6SF2 0.36 5.85 0.31 1.19e-8 Tonsillectomy; CRC cis rs9902453 0.868 rs11080118 chr17:28475379 A/G cg26525008 chr17:28256777 EFCAB5;SSH2 -0.68 -11.15 -0.52 1.08e-24 Coffee consumption (cups per day); CRC cis rs524281 0.773 rs7951079 chr11:65980550 C/T cg16950941 chr11:66035639 RAB1B -0.72 -8.05 -0.41 1.49e-14 Electroencephalogram traits; CRC cis rs12745968 0.589 rs1059267 chr1:92975262 C/A cg17283838 chr1:93427260 FAM69A -0.48 -6.49 -0.34 3.16e-10 Bipolar disorder and schizophrenia; CRC cis rs7918232 0.567 rs11015463 chr10:27319258 A/G cg14240646 chr10:27532245 ACBD5 -0.62 -6.91 -0.36 2.51e-11 Breast cancer; CRC cis rs883565 0.792 rs784490 chr3:39173530 C/T cg01426195 chr3:39028469 NA -0.39 -5.62 -0.3 4.04e-8 Handedness; CRC cis rs10197940 0.624 rs3771901 chr2:152432481 G/A cg06191203 chr2:152266755 RIF1 -0.66 -9.38 -0.46 1.11e-18 Lung cancer; CRC cis rs2290159 0.571 rs7637392 chr3:12696433 A/G cg23032965 chr3:12705835 RAF1 0.46 6.32 0.33 8.43e-10 Cholesterol, total; CRC trans rs2303319 0.504 rs12470830 chr2:162429996 C/T cg22677401 chr17:46026860 NA -0.7 -6.05 -0.32 3.89e-9 Cognitive function; CRC trans rs916888 0.773 rs199448 chr17:44809001 A/G cg13957321 chr17:43675089 NA 0.5 6.27 0.33 1.13e-9 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs9291683 0.551 rs2240720 chr4:10020480 C/T cg11266682 chr4:10021025 SLC2A9 0.54 11.58 0.54 2.96e-26 Bone mineral density; CRC cis rs7772486 0.727 rs12190966 chr6:146146820 T/G cg13319975 chr6:146136371 FBXO30 -0.45 -6.75 -0.35 6.54e-11 Lobe attachment (rater-scored or self-reported); CRC cis rs2380220 0.606 rs4571572 chr6:96004823 T/C cg15832292 chr6:96025679 MANEA 0.64 7.71 0.39 1.47e-13 Behavioural disinhibition (generation interaction); CRC trans rs1455244 0.700 rs7229302 chr18:11508904 G/T cg16632661 chr19:45251986 BCL3 0.4 6.02 0.31 4.69e-9 Schizophrenia; CRC cis rs2067615 0.524 rs4246257 chr12:107062329 C/T cg13491945 chr12:107078410 RFX4 0.35 6.16 0.32 2.11e-9 Heart rate; CRC cis rs2732480 0.500 rs11168464 chr12:48602115 C/T cg04545296 chr12:48745243 ZNF641 0.33 5.9 0.31 9.23e-9 Hemoglobin concentration;Red blood cell count;Hematocrit; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg17472796 chr11:72406685 ARAP1 -0.38 -6.35 -0.33 7.21e-10 Liver disease severity in Alagille syndrome; CRC cis rs7945718 0.967 rs12291695 chr11:12795662 A/G cg25843174 chr11:12811716 TEAD1 -0.47 -8.73 -0.43 1.26e-16 Educational attainment (years of education); CRC cis rs62229266 0.633 rs743420 chr21:37387402 A/G cg08632701 chr21:37451849 NA -0.38 -5.95 -0.31 6.99e-9 Mitral valve prolapse; CRC cis rs7647973 1.000 rs62259944 chr3:49430883 G/A cg20833759 chr3:49053208 WDR6;DALRD3 -0.6 -8.76 -0.43 1.04e-16 Menarche (age at onset); CRC cis rs6901250 0.851 rs339313 chr6:117179501 C/T cg12892004 chr6:117198278 RFX6 -0.43 -6.76 -0.35 6.21e-11 C-reactive protein levels; CRC trans rs3942852 0.868 rs11039514 chr11:48109598 A/G cg15704280 chr7:45808275 SEPT13 -0.56 -6.87 -0.35 3.25e-11 Acute lymphoblastic leukemia (childhood); CRC trans rs1814175 0.558 rs5025146 chr11:49795724 C/G cg11707556 chr5:10655725 ANKRD33B -0.52 -9.74 -0.47 7.14e-20 Height; CRC cis rs853679 0.517 rs34716816 chr6:28046169 C/A cg15845792 chr6:28175446 NA 0.97 13.03 0.58 1.43e-31 Depression; CRC cis rs225245 0.782 rs321601 chr17:33892087 A/C cg05299278 chr17:33885742 SLFN14 -0.49 -8.0 -0.4 2.14e-14 Reticulocyte count;Reticulocyte fraction of red cells;High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells; CRC cis rs2952156 0.920 rs903502 chr17:37829604 C/T cg20243544 chr17:37824526 PNMT 0.57 9.04 0.45 1.33e-17 Asthma; CRC cis rs17666538 0.710 rs7834337 chr8:655828 A/G cg23958373 chr8:599963 NA 0.81 8.22 0.41 4.67e-15 IgG glycosylation; CRC cis rs10751667 0.643 rs10751671 chr11:944479 T/G ch.11.42038R chr11:967971 AP2A2 0.58 9.85 0.48 3.1e-20 Alzheimer's disease (late onset); CRC cis rs968567 0.528 rs174582 chr11:61607168 A/G cg21709803 chr11:61594965 FADS2 -0.46 -5.87 -0.31 1.09e-8 Blood metabolite levels;Rheumatoid arthritis;Vitiligo;Glycerophospholipid levels; CRC cis rs12893668 0.645 rs12889403 chr14:104034746 C/T cg08213375 chr14:104286397 PPP1R13B 0.37 5.81 0.31 1.46e-8 Reticulocyte count; CRC cis rs600806 0.850 rs10776807 chr1:109956156 A/G cg23032129 chr1:109941072 SORT1 0.28 6.05 0.32 3.87e-9 Intelligence (multi-trait analysis); CRC cis rs4975616 0.686 rs37008 chr5:1351538 C/T cg26373071 chr5:1325741 CLPTM1L 0.48 8.35 0.42 1.86e-15 Lung cancer; CRC cis rs2252790 0.794 rs1204808 chr6:116550917 A/G cg18764771 chr6:116381957 FRK -0.21 -5.63 -0.3 3.93e-8 Fast beta electroencephalogram; CRC cis rs7523050 0.643 rs7551313 chr1:109399881 G/A cg08274380 chr1:109419600 GPSM2 0.84 6.6 0.34 1.69e-10 Fat distribution (HIV); CRC trans rs6703335 0.870 rs10803142 chr1:243598234 A/G cg01213331 chr16:15069449 PDXDC1 0.44 6.01 0.31 4.97e-9 Schizophrenia;Schizophrenia, schizoaffective disorder or bipolar disorder; CRC cis rs3087591 0.922 rs12939969 chr17:29463577 A/G cg24425628 chr17:29625626 OMG;NF1 0.83 15.67 0.65 9.99e-42 Hip circumference; CRC cis rs11122272 0.735 rs722302 chr1:231480152 A/C cg06096015 chr1:231504339 EGLN1 0.38 5.61 0.3 4.23e-8 Hemoglobin concentration; CRC cis rs6089584 0.566 rs7274240 chr20:60622004 C/T cg23463467 chr20:60627584 TAF4 0.41 7.83 0.4 6.7e-14 Body mass index; CRC cis rs11229555 0.645 rs11229549 chr11:58395914 T/C cg15696309 chr11:58395628 NA -0.87 -9.15 -0.45 6.24e-18 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; CRC cis rs17376456 1.000 rs6867042 chr5:93555761 C/T cg21475434 chr5:93447410 FAM172A 0.74 6.87 0.35 3.28e-11 Diabetic retinopathy; CRC cis rs1451375 0.698 rs12669770 chr7:50656334 G/A cg18232548 chr7:50535776 DDC 0.44 6.2 0.32 1.7e-9 Malaria; CRC cis rs7493 0.755 rs17886036 chr7:94987727 C/A cg17330251 chr7:94953956 PON1 -0.52 -6.68 -0.35 9.94e-11 Yu-Zhi constitution type in type 2 diabetes; CRC trans rs35110281 0.659 rs2236667 chr21:45112939 A/G cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.39 6.32 0.33 8.46e-10 Mean corpuscular volume; CRC cis rs60871478 0.898 rs4720929 chr7:808009 T/C cg05535760 chr7:792225 HEATR2 0.8 10.66 0.51 5.61e-23 Cerebrospinal P-tau181p levels; CRC cis rs28386778 0.897 rs2044125 chr17:61863184 A/C cg00280220 chr17:61926910 NA -0.34 -5.67 -0.3 3.05e-8 Prudent dietary pattern; CRC cis rs1499614 1.000 rs1882655 chr7:66147057 T/C cg12463550 chr7:65579703 CRCP -0.65 -5.91 -0.31 8.34e-9 Gout; CRC cis rs72717009 0.825 rs12746613 chr1:161467042 A/G cg15358701 chr1:161410459 NA 0.65 6.8 0.35 4.98e-11 Rheumatoid arthritis; CRC cis rs2734839 0.537 rs6277 chr11:113283459 G/A cg14159747 chr11:113255604 NA 0.59 11.42 0.53 1.19e-25 Information processing speed; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg12413365 chr12:12510412 LOH12CR1;LOH12CR2 0.48 6.16 0.32 2.16e-9 Thyroid stimulating hormone; CRC cis rs9462846 0.845 rs9471964 chr6:42885664 C/A cg21280719 chr6:42927975 GNMT -0.35 -6.66 -0.34 1.16e-10 Blood protein levels; CRC cis rs7568458 0.709 rs2043675 chr2:85769975 C/T cg02493740 chr2:85810744 VAMP5 0.52 7.88 0.4 4.99e-14 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); CRC cis rs4268898 0.552 rs12620938 chr2:24367122 C/A cg06627628 chr2:24431161 ITSN2 0.45 6.86 0.35 3.47e-11 Asthma; CRC cis rs7772486 0.654 rs1011597 chr6:146075672 A/C cg13319975 chr6:146136371 FBXO30 0.45 6.77 0.35 6.01e-11 Lobe attachment (rater-scored or self-reported); CRC trans rs7395662 0.929 rs7952580 chr11:48595206 G/A cg21153622 chr11:89784906 NA -0.48 -7.74 -0.39 1.26e-13 HDL cholesterol; CRC cis rs951366 0.903 rs823116 chr1:205720483 G/A cg17178900 chr1:205818956 PM20D1 0.44 6.58 0.34 1.88e-10 Menarche (age at onset); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg02947222 chr12:76425514 PHLDA1 0.43 6.03 0.32 4.33e-9 Response to antipsychotic treatment; CRC cis rs853679 0.527 rs853690 chr6:28285482 G/A cg03623178 chr6:28175578 NA 0.48 6.61 0.34 1.54e-10 Depression; CRC cis rs17376456 0.741 rs10036829 chr5:93309897 G/C cg09848695 chr5:92956644 FAM172A;MIR2277 0.63 5.67 0.3 3.18e-8 Diabetic retinopathy; CRC cis rs7517126 0.541 rs9427656 chr1:196943020 A/T cg13682187 chr1:196946512 CFHR5 -0.46 -6.83 -0.35 4.06e-11 Blood protein levels; CRC cis rs9611565 0.694 rs5758347 chr22:41821019 G/T cg03806693 chr22:41940476 POLR3H 1.1 13.52 0.6 1.95e-33 Vitiligo; CRC cis rs875971 0.965 rs28682868 chr7:65689809 C/T cg12463550 chr7:65579703 CRCP -0.49 -7.14 -0.37 6.07e-12 Aortic root size; CRC cis rs311392 0.934 rs376589 chr8:55088289 G/A cg20636351 chr8:55087400 NA -0.34 -6.0 -0.31 5.17e-9 Pelvic organ prolapse (moderate/severe); CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg02480104 chr20:35808036 C20orf132;RPN2 0.47 6.48 0.34 3.36e-10 Anxiety disorder; CRC cis rs6429082 0.521 rs291390 chr1:235649678 T/C cg26050004 chr1:235667680 B3GALNT2 0.74 12.56 0.57 7.83e-30 Adiposity; CRC cis rs9302635 0.513 rs7184169 chr16:72152933 C/T cg23815491 chr16:72088622 HP 0.65 8.43 0.42 1.08e-15 Blood protein levels; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg09665592 chr9:130699885 DPM2 0.43 6.16 0.32 2.09e-9 Intelligence (multi-trait analysis); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg00822591 chr3:16306489 DPH3;OXNAD1 0.39 6.24 0.33 1.38e-9 Liver disease severity in Alagille syndrome; CRC cis rs17023223 0.537 rs2645301 chr1:119590420 C/T cg05756136 chr1:119680316 WARS2 -0.47 -6.29 -0.33 1.01e-9 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for BMI in active individuals; CRC cis rs8060686 0.858 rs11553287 chr16:67905407 A/G cg00318322 chr16:67708822 GFOD2 -0.31 -5.92 -0.31 8.03e-9 HDL cholesterol;Metabolic syndrome; CRC cis rs6952808 0.895 rs12669518 chr7:1921429 G/C cg04267008 chr7:1944627 MAD1L1 -0.73 -11.23 -0.53 5.5e-25 Bipolar disorder and schizophrenia; CRC cis rs7089973 0.604 rs1924034 chr10:116578539 C/T cg23260525 chr10:116636907 FAM160B1 0.39 9.06 0.45 1.16e-17 Bipolar disorder or attention deficit hyperactivity disorder; CRC cis rs8044868 0.530 rs9928157 chr16:72117073 T/C cg06172871 chr16:72088244 HP 0.4 5.82 0.31 1.39e-8 Body mass index (change over time) in cancer or chronic obstructive pulmonary disease;Body mass index (change over time) in cancer; CRC cis rs875971 1.000 rs2420591 chr7:65912381 T/C cg11764359 chr7:65958608 NA 0.62 9.91 0.48 1.96e-20 Aortic root size; CRC cis rs9522267 0.535 rs9522304 chr13:112237316 C/T cg14352298 chr13:112236639 NA 0.29 6.59 0.34 1.74e-10 Hepatitis; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg00455883 chr3:73046007 PPP4R2 0.43 6.91 0.36 2.44e-11 Liver disease severity in Alagille syndrome; CRC cis rs8060686 0.641 rs76984161 chr16:68139423 C/A cg08314208 chr16:67682810 RLTPR -0.58 -6.23 -0.32 1.47e-9 HDL cholesterol;Metabolic syndrome; CRC cis rs916888 0.773 rs199443 chr17:44819565 C/T cg15921436 chr17:44337874 NA 0.79 8.7 0.43 1.64e-16 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs7618915 1.000 rs3852064 chr3:52349412 G/T cg18404041 chr3:52824283 ITIH1 -0.37 -7.06 -0.36 9.89e-12 Bipolar disorder; CRC cis rs875971 0.545 rs73148639 chr7:65855329 A/T cg11764359 chr7:65958608 NA 0.45 5.7 0.3 2.67e-8 Aortic root size; CRC cis rs4692589 0.803 rs4145964 chr4:170985398 C/T cg19918862 chr4:170955249 NA -0.34 -5.68 -0.3 2.95e-8 Anxiety disorder; CRC cis rs7615952 0.641 rs60839048 chr3:125807938 G/A cg06494592 chr3:125709126 NA -0.58 -6.85 -0.35 3.57e-11 Blood pressure (smoking interaction); CRC trans rs11165623 0.792 rs2104236 chr1:96908690 C/T cg10631902 chr5:14652156 NA -0.51 -9.59 -0.47 2.29e-19 Hip circumference;Waist circumference; CRC cis rs2180341 0.889 rs2000909 chr6:127711173 G/A cg24812749 chr6:127587940 RNF146 0.68 9.36 0.46 1.27e-18 Breast cancer; CRC cis rs644799 1.000 rs586498 chr11:95537828 C/T cg03916912 chr11:95522834 CEP57;FAM76B 0.95 18.15 0.71 1.71e-51 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs7044106 0.762 rs1411158 chr9:123464804 A/G cg09419670 chr9:123605666 PSMD5;LOC253039 0.71 11.62 0.54 2.22e-26 Hip circumference adjusted for BMI; CRC trans rs6601327 0.606 rs13268319 chr8:9579249 C/A cg06636001 chr8:8085503 FLJ10661 -0.51 -7.43 -0.38 9.16e-13 Multiple myeloma (hyperdiploidy); CRC cis rs644799 0.601 rs662168 chr11:95586982 C/T cg25478527 chr11:95522999 CEP57;FAM76B 0.42 6.4 0.33 5.37e-10 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC trans rs11671005 0.610 rs8103813 chr19:59072684 C/T cg22037779 chr5:139682734 PFDN1 -0.54 -6.38 -0.33 5.98e-10 Mean platelet volume; CRC cis rs6758955 0.850 rs60661460 chr2:10478239 A/G cg15773312 chr2:10472214 HPCAL1 -0.81 -9.63 -0.47 1.73e-19 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; CRC cis rs7584330 0.554 rs55919896 chr2:238428823 A/T cg14458575 chr2:238380390 NA 0.48 6.45 0.34 3.96e-10 Prostate cancer; CRC cis rs7618915 0.547 rs10780035 chr3:52764624 C/T cg07507251 chr3:52567010 NT5DC2 0.44 6.39 0.33 5.81e-10 Bipolar disorder; CRC cis rs11190604 0.945 rs11190573 chr10:102233172 T/C cg16342193 chr10:102329863 NA -0.36 -5.84 -0.31 1.25e-8 Palmitoleic acid (16:1n-7) levels; CRC cis rs2179367 0.887 rs2789492 chr6:149747379 A/G cg11245181 chr6:149772854 ZC3H12D 0.37 5.87 0.31 1.06e-8 Dupuytren's disease; CRC cis rs10504229 0.683 rs11775568 chr8:58133762 G/A cg22535103 chr8:58192502 C8orf71 -0.73 -8.34 -0.42 2.06e-15 Developmental language disorder (linguistic errors); CRC cis rs7590720 0.704 rs7603645 chr2:216876949 C/G cg12620499 chr2:216877984 MREG 0.98 19.96 0.74 1.28e-58 Alcohol dependence; CRC cis rs4665809 0.590 rs4665837 chr2:26434022 C/A cg04944784 chr2:26401820 FAM59B -0.86 -11.14 -0.52 1.12e-24 Gut microbiome composition (summer); CRC cis rs1215050 0.755 rs1238462 chr4:98850603 A/G cg05340658 chr4:99064831 C4orf37 -0.48 -7.21 -0.37 3.82e-12 Waist-to-hip ratio adjusted for body mass index; CRC cis rs7208859 0.673 rs3764421 chr17:29167653 A/C cg14008862 chr17:28927542 LRRC37B2 0.55 5.76 0.3 1.98e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs4722166 0.604 rs2390715 chr7:22783878 A/C cg05472934 chr7:22766657 IL6 0.77 12.5 0.57 1.37e-29 Lung cancer; CRC cis rs61160187 0.582 rs67858932 chr5:60143251 A/G cg16298547 chr5:60138761 ELOVL7 -0.28 -5.77 -0.3 1.78e-8 Educational attainment (years of education);Educational attainment (college completion); CRC cis rs1878931 0.501 rs28735976 chr16:3418419 G/A cg26668626 chr16:3451006 ZNF174;ZNF434 0.7 9.62 0.47 1.8e-19 Body mass index (adult); CRC cis rs4268898 0.862 rs11125549 chr2:24576240 C/T cg06627628 chr2:24431161 ITSN2 0.47 7.02 0.36 1.26e-11 Asthma; CRC trans rs11098499 1.000 rs13435802 chr4:120177960 A/T cg25214090 chr10:38739885 LOC399744 -0.52 -7.92 -0.4 3.77e-14 Corneal astigmatism; CRC cis rs17826219 0.636 rs79565452 chr17:29142841 T/C cg13385521 chr17:29058706 SUZ12P 0.73 8.39 0.42 1.43e-15 Body mass index; CRC cis rs72781680 0.898 rs55761273 chr2:23957849 A/G cg08917208 chr2:24149416 ATAD2B 0.86 8.45 0.42 9.69e-16 Lymphocyte counts; CRC cis rs4665809 0.590 rs1122972 chr2:26418788 A/C cg25036284 chr2:26402008 FAM59B -0.6 -7.65 -0.39 2.29e-13 Gut microbiome composition (summer); CRC cis rs6502050 0.835 rs8071425 chr17:80117335 C/T cg09264619 chr17:80180166 NA 0.35 5.82 0.31 1.37e-8 Life satisfaction; CRC cis rs6461049 0.765 rs4719432 chr7:2140330 A/G cg21782813 chr7:2030301 MAD1L1 0.4 7.12 0.37 6.93e-12 Schizophrenia; CRC cis rs643506 1.000 rs647080 chr11:111609174 A/G cg09085632 chr11:111637200 PPP2R1B 0.46 6.17 0.32 2.05e-9 Breast cancer; CRC trans rs17685 0.753 rs1639609 chr7:75683581 T/C cg19862616 chr7:65841803 NCRNA00174 0.98 18.35 0.71 2.74e-52 Coffee consumption;Coffee consumption (cups per day); CRC cis rs4737010 0.501 rs55694640 chr8:41649439 T/G cg17182837 chr8:41585554 ANK1 -0.52 -6.91 -0.36 2.53e-11 Lymphocyte counts;High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Reticulocyte count;Reticulocyte fraction of red cells;Mean corpuscular volume;Immature fraction of reticulocytes;Mean corpuscular hemoglobin concentration; CRC cis rs9326248 0.539 rs7120565 chr11:117042949 T/C cg10398005 chr11:117014888 PAFAH1B2 -0.45 -6.77 -0.35 5.76e-11 Blood protein levels; CRC cis rs694739 0.541 rs61886926 chr11:64133552 C/T cg23796481 chr11:64053134 BAD;GPR137 0.48 6.68 0.35 9.99e-11 Alopecia areata;Crohn's disease;Psoriasis vulgaris; CRC cis rs7712401 0.655 rs6884312 chr5:122103977 A/C cg18764291 chr5:122110994 SNX2 0.37 5.91 0.31 8.74e-9 Mean platelet volume; CRC cis rs7618915 0.547 rs11177 chr3:52721305 G/A cg07507251 chr3:52567010 NT5DC2 0.46 6.61 0.34 1.54e-10 Bipolar disorder; CRC cis rs9467711 0.606 rs9379863 chr6:26372427 A/G cg14345882 chr6:26364793 BTN3A2 0.65 5.73 0.3 2.32e-8 Autism spectrum disorder or schizophrenia; CRC cis rs12701220 0.894 rs8591 chr7:1036799 C/T cg26240231 chr7:1148101 C7orf50 -0.42 -5.98 -0.31 5.96e-9 Bronchopulmonary dysplasia; CRC cis rs597539 0.689 rs596874 chr11:68630874 C/T cg04772025 chr11:68637568 NA -0.46 -7.58 -0.39 3.62e-13 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs9905704 0.846 rs7212271 chr17:56863918 C/T cg12560992 chr17:57184187 TRIM37 0.55 7.95 0.4 3.04e-14 Testicular germ cell tumor; CRC cis rs9291683 0.566 rs13122689 chr4:10044648 A/G cg11266682 chr4:10021025 SLC2A9 0.52 10.62 0.51 7.35e-23 Bone mineral density; CRC cis rs57221529 0.766 rs4081846 chr5:574019 G/A cg17948913 chr5:572064 NA 0.55 6.34 0.33 7.56e-10 Lung disease severity in cystic fibrosis; CRC cis rs6908034 0.607 rs73376655 chr6:19805664 C/T cg02682789 chr6:19804855 NA 0.8 6.74 0.35 6.9e-11 Endometriosis;Deep ovarian and/or rectovaginal disease with dense adhesions; CRC cis rs13064411 0.518 rs2669909 chr3:113265727 A/G cg18753928 chr3:113234510 CCDC52 0.46 7.39 0.38 1.21e-12 Response to simvastatin treatment (PCSK9 protein level change); CRC cis rs35000415 0.938 rs13239597 chr7:128695983 C/A cg19972273 chr7:128594194 NA 0.71 6.15 0.32 2.2e-9 Systemic lupus erythematosus; CRC cis rs2228479 0.850 rs62052660 chr16:89847420 T/A cg06656553 chr16:89960601 TCF25 -0.71 -5.96 -0.31 6.42e-9 Skin colour saturation; CRC cis rs55788414 1.000 rs67345347 chr16:81185125 G/C cg06400318 chr16:81190750 PKD1L2 -0.6 -6.87 -0.35 3.27e-11 Left ventricular obstructive tract defect (maternal effect); CRC trans rs2303319 0.504 rs62189054 chr2:162624654 C/G cg10272801 chr16:14013773 ERCC4 -0.68 -6.07 -0.32 3.49e-9 Cognitive function; CRC trans rs116095464 0.558 rs7356696 chr5:284251 A/G cg00938859 chr5:1591904 SDHAP3 0.71 7.58 0.39 3.45e-13 Breast cancer; CRC cis rs7178572 0.625 rs907372 chr15:77844516 G/T cg22256960 chr15:77711686 NA -0.55 -8.36 -0.42 1.73e-15 Type 2 diabetes; CRC cis rs4478858 0.735 rs68008576 chr1:31805905 T/C cg00250761 chr1:31883323 NA -0.44 -8.5 -0.42 6.71e-16 Alcohol dependence; CRC cis rs4862750 0.872 rs7672831 chr4:187898882 C/T cg10295955 chr4:187884368 NA -1.04 -27.49 -0.83 3.05e-87 Lobe attachment (rater-scored or self-reported); CRC cis rs801193 0.660 rs1016265 chr7:66214567 C/T cg11764359 chr7:65958608 NA 0.6 9.22 0.45 3.61e-18 Aortic root size; CRC cis rs7659604 1.000 rs7689722 chr4:122665955 T/C cg06713675 chr4:122721982 EXOSC9 -0.4 -6.56 -0.34 2.05e-10 Type 2 diabetes; CRC cis rs1552244 1.000 rs35220123 chr3:10083169 C/T cg08888203 chr3:10149979 C3orf24 0.73 10.08 0.49 5.45e-21 Alzheimer's disease; CRC cis rs1005277 0.540 rs289638 chr10:37923731 G/A cg25427524 chr10:38739819 LOC399744 -0.7 -11.92 -0.55 1.85e-27 Extrinsic epigenetic age acceleration; CRC cis rs12928939 0.911 rs77823468 chr16:71828616 C/T cg08717414 chr16:71523259 ZNF19 -0.5 -6.19 -0.32 1.75e-9 Post bronchodilator FEV1; CRC cis rs2243480 1.000 rs781157 chr7:65478311 G/A cg12463550 chr7:65579703 CRCP 0.65 6.24 0.33 1.32e-9 Diabetic kidney disease; CRC cis rs8141529 0.702 rs469991 chr22:29307859 G/C cg02153584 chr22:29168773 CCDC117 -0.47 -6.83 -0.35 4.2e-11 Lymphocyte counts; CRC cis rs28386778 0.669 rs12603821 chr17:62006432 G/A cg23090583 chr17:61904693 PSMC5;FTSJ3 -0.68 -10.26 -0.49 1.32e-21 Prudent dietary pattern; CRC cis rs863345 0.584 rs11265018 chr1:158506409 G/A cg12129480 chr1:158549410 OR10X1 -0.3 -6.27 -0.33 1.12e-9 Pneumococcal bacteremia; CRC trans rs6462411 0.938 rs6968948 chr7:3912319 C/T cg17780657 chr19:45971055 FOSB 0.52 6.33 0.33 8.09e-10 Quantitative traits; CRC cis rs5769765 0.773 rs9616395 chr22:50317803 A/G cg22709217 chr22:50311962 ALG12;CRELD2 -0.96 -12.45 -0.57 2.05e-29 Schizophrenia; CRC cis rs6906287 0.647 rs11153753 chr6:118836153 T/C cg15382696 chr6:118971807 C6orf204 -0.33 -5.61 -0.3 4.31e-8 Electrocardiographic conduction measures; CRC cis rs6952808 0.893 rs35487994 chr7:1920171 G/A cg00106254 chr7:1943704 MAD1L1 -0.56 -8.44 -0.42 1.05e-15 Bipolar disorder and schizophrenia; CRC cis rs35520189 0.591 rs12995439 chr2:113703646 T/C cg12858261 chr2:113808755 IL1F8 0.46 6.0 0.31 5.15e-9 Obstructive sleep apnea trait (apnea hypopnea index); CRC cis rs8180040 0.967 rs807935 chr3:47321669 A/G cg27129171 chr3:47204927 SETD2 0.57 8.88 0.44 4.4e-17 Colorectal cancer; CRC cis rs908922 0.676 rs7532535 chr1:152517597 T/A cg09873164 chr1:152488093 CRCT1 0.39 6.58 0.34 1.84e-10 Hair morphology; CRC cis rs748404 0.646 rs2253268 chr15:43800968 A/C cg02155558 chr15:43621948 ADAL;LCMT2 0.51 7.38 0.38 1.34e-12 Lung cancer; CRC cis rs4891159 0.548 rs609487 chr18:74134382 C/G cg24786174 chr18:74118243 ZNF516 -0.92 -21.24 -0.76 1.24e-63 Longevity; CRC cis rs4319547 0.956 rs9988963 chr12:122991478 C/G cg23029597 chr12:123009494 RSRC2 -0.66 -8.49 -0.42 7.36e-16 Body mass index; CRC cis rs9549260 0.755 rs9549241 chr13:41210041 G/A cg21288729 chr13:41239152 FOXO1 0.48 7.59 0.39 3.34e-13 Red blood cell count; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg12713848 chr20:35401901 DSN1 0.44 6.51 0.34 2.74e-10 Anxiety disorder; CRC cis rs1218582 0.741 rs7544528 chr1:154844585 C/T cg06221963 chr1:154839813 KCNN3 -0.82 -17.04 -0.68 4.16e-47 Prostate cancer; CRC cis rs7666738 0.830 rs7664340 chr4:99037820 C/T cg17366294 chr4:99064904 C4orf37 0.43 7.15 0.37 5.68e-12 Colonoscopy-negative controls vs population controls; CRC cis rs933688 1.000 rs11948075 chr5:90680579 A/G cg26981201 chr5:90679533 LOC100129716;ARRDC3 1.02 15.59 0.65 1.97e-41 Smoking behavior; CRC trans rs1814175 0.645 rs28454367 chr11:50045708 G/A cg03929089 chr4:120376271 NA -0.89 -15.95 -0.66 7.68e-43 Height; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg09845946 chr2:204192806 ABI2 0.43 6.08 0.32 3.35e-9 Response to antipsychotic treatment; CRC cis rs6570726 0.935 rs368848 chr6:145855281 A/T cg05347473 chr6:146136440 FBXO30 0.38 6.11 0.32 2.84e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs9768139 0.935 rs7800718 chr7:158121878 G/A cg23298862 chr7:158159286 PTPRN2 -0.49 -8.05 -0.41 1.52e-14 Calcium levels; CRC cis rs5753618 0.561 rs715510 chr22:31690528 T/A cg22777020 chr22:31556080 RNF185 -0.52 -6.0 -0.31 5.18e-9 Colorectal cancer; CRC cis rs12681288 0.676 rs2701910 chr8:1001246 G/T cg15309053 chr8:964076 NA 0.41 6.83 0.35 4.23e-11 Schizophrenia; CRC cis rs4713118 0.513 rs149962 chr6:28015918 G/A cg12273811 chr6:28175739 NA 0.56 8.01 0.4 2.05e-14 Parkinson's disease; CRC cis rs763121 1.000 rs138457 chr22:38898051 T/C cg06544989 chr22:39130855 UNC84B -0.48 -7.85 -0.4 5.73e-14 Menopause (age at onset); CRC cis rs6570726 0.818 rs952405 chr6:145925952 T/C cg23711669 chr6:146136114 FBXO30 0.69 11.45 0.53 8.93e-26 Lobe attachment (rater-scored or self-reported); CRC trans rs6600671 0.934 rs12131379 chr1:121293437 T/C cg09829573 chr1:144692074 NBPF9 -0.42 -6.32 -0.33 8.74e-10 Hip geometry; CRC cis rs7772486 0.790 rs4896852 chr6:146284621 T/C cg23711669 chr6:146136114 FBXO30 -0.73 -12.56 -0.57 8.18e-30 Lobe attachment (rater-scored or self-reported); CRC cis rs10991814 1.000 rs17579908 chr9:93948636 G/C cg14446406 chr9:93919335 NA 0.56 6.39 0.33 5.7e-10 Neutrophil percentage of granulocytes; CRC cis rs1797081 0.967 rs811912 chr10:16859618 G/C cg23933602 chr10:16859644 RSU1 1.09 24.21 0.8 4.5e-75 Platelet distribution width; CRC cis rs782590 0.818 rs2627765 chr2:55883317 G/T cg18811423 chr2:55921094 PNPT1 0.81 14.04 0.61 2.06e-35 Metabolic syndrome; CRC cis rs9491140 0.539 rs12204076 chr6:124693493 A/G cg19267163 chr6:125004984 NKAIN2 0.47 6.08 0.32 3.38e-9 Neuroticism; CRC trans rs561341 0.654 rs6505265 chr17:30172580 C/T cg27661571 chr11:113659931 NA 0.58 7.02 0.36 1.26e-11 Hip circumference adjusted for BMI; CRC cis rs13108904 0.905 rs1680074 chr4:1279621 G/A cg21620606 chr4:1342894 KIAA1530 -0.43 -7.81 -0.4 7.76e-14 Obesity-related traits; CRC cis rs2292864 1.000 rs2292864 chr17:45367681 C/T cg18085866 chr17:45331354 ITGB3 -0.59 -5.94 -0.31 7.4e-9 Left atrial antero-posterior diameter; CRC cis rs13191362 1.000 rs34594856 chr6:163051845 C/T cg06582575 chr6:163149167 PACRG;PARK2 0.93 11.69 0.54 1.18e-26 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs4713675 0.565 rs4713665 chr6:33674419 T/G cg14003231 chr6:33640908 ITPR3 0.51 8.26 0.41 3.71e-15 Plateletcrit; CRC cis rs853679 0.666 rs200956 chr6:27839746 A/G cg03623178 chr6:28175578 NA 0.73 8.67 0.43 2.02e-16 Depression; CRC cis rs2249694 0.960 rs2515642 chr10:135352013 C/T cg16964102 chr10:135390573 NA -0.38 -6.21 -0.32 1.57e-9 Obesity-related traits; CRC cis rs2239547 0.657 rs6445539 chr3:52874296 G/A cg18404041 chr3:52824283 ITIH1 -0.4 -7.5 -0.38 5.93e-13 Schizophrenia; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg16176301 chr11:8933372 ST5;C11orf17 0.44 6.12 0.32 2.61e-9 Response to antipsychotic treatment; CRC cis rs12044355 0.929 rs6667123 chr1:231851991 C/G cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX 0.45 6.24 0.33 1.32e-9 Alzheimer's disease; CRC cis rs17376456 0.877 rs13165147 chr5:93422214 G/A cg21475434 chr5:93447410 FAM172A 0.74 7.63 0.39 2.59e-13 Diabetic retinopathy; CRC cis rs7584330 0.868 rs13386290 chr2:238393136 G/C cg14458575 chr2:238380390 NA 0.67 11.85 0.55 3.1e-27 Prostate cancer; CRC trans rs4745216 0.643 rs2795116 chr9:75773161 A/G cg11926456 chr2:211432972 CPS1 0.56 6.09 0.32 3.14e-9 Blood protein levels; CRC cis rs992157 0.835 rs7585702 chr2:219146607 T/C cg00012203 chr2:219082015 ARPC2 -0.47 -7.07 -0.36 9.09e-12 Colorectal cancer; CRC cis rs9443645 0.869 rs7756858 chr6:79619968 A/G cg09184832 chr6:79620586 NA -0.49 -9.0 -0.44 1.8e-17 Intelligence (multi-trait analysis); CRC cis rs4555082 0.874 rs2816612 chr14:105723103 C/T cg13114125 chr14:105738426 BRF1 -0.81 -11.69 -0.54 1.2e-26 Mean platelet volume;Platelet distribution width; CRC trans rs7267979 0.727 rs2474765 chr20:25245950 G/T cg17903999 chr18:56338584 MALT1 -0.41 -6.42 -0.33 4.79e-10 Liver enzyme levels (alkaline phosphatase); CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg04047710 chr21:34143336 C21orf66;C21orf49 -0.57 -6.86 -0.35 3.4e-11 Diisocyanate-induced asthma; CRC trans rs35110281 0.626 rs162388 chr21:44936032 G/A cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.42 6.68 0.35 1.02e-10 Mean corpuscular volume; CRC cis rs514406 0.825 rs28817407 chr1:53226116 G/A cg25767906 chr1:53392781 SCP2 0.45 7.12 0.37 6.95e-12 Monocyte count; CRC cis rs769267 0.895 rs2905435 chr19:19495954 G/A cg01262667 chr19:19385393 TM6SF2 -0.37 -6.2 -0.32 1.7e-9 Tonsillectomy; CRC cis rs7617480 0.610 rs10865954 chr3:49211989 T/C cg18654377 chr3:49208889 KLHDC8B -0.37 -5.69 -0.3 2.78e-8 Subjective well-being (multi-trait analysis);Menarche (age at onset); CRC cis rs7568458 0.846 rs6705839 chr2:85761279 A/T cg02493740 chr2:85810744 VAMP5 -0.4 -6.36 -0.33 6.86e-10 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); CRC cis rs67311347 0.910 rs7617361 chr3:40373259 G/T cg24209194 chr3:40518798 ZNF619 0.43 6.64 0.34 1.27e-10 Renal cell carcinoma; CRC trans rs9858542 0.953 rs6803222 chr3:49665976 T/G cg21659725 chr3:3221576 CRBN -0.69 -9.07 -0.45 1.1e-17 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs72615157 0.634 rs74774557 chr7:99810425 A/G cg07160278 chr7:100027354 MEPCE;ZCWPW1 0.72 8.62 0.43 2.9e-16 Lung function (FEV1/FVC); CRC trans rs2243480 1.000 rs34192067 chr7:65887657 C/A cg10756647 chr7:56101905 PSPH 0.78 8.01 0.4 1.97e-14 Diabetic kidney disease; CRC cis rs8060686 0.668 rs255056 chr16:68016185 G/C cg26727032 chr16:67993705 SLC12A4 -0.51 -5.68 -0.3 2.9e-8 HDL cholesterol;Metabolic syndrome; CRC cis rs1707322 0.964 rs10437063 chr1:46273666 G/A cg03146154 chr1:46216737 IPP 0.51 7.26 0.37 2.84e-12 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs1878931 0.545 rs28603 chr16:3449479 A/G cg26668626 chr16:3451006 ZNF174;ZNF434 -0.54 -5.84 -0.31 1.28e-8 Body mass index (adult); CRC cis rs6088580 0.624 rs6120645 chr20:33025171 C/T cg24642439 chr20:33292090 TP53INP2 0.36 6.11 0.32 2.77e-9 Glomerular filtration rate (creatinine); CRC cis rs992157 0.764 rs10932774 chr2:219191569 A/G cg04731861 chr2:219085781 ARPC2 -0.3 -6.0 -0.31 5.24e-9 Colorectal cancer; CRC trans rs916888 0.773 rs199457 chr17:44795469 C/T cg22433210 chr17:43662623 NA 0.98 10.23 0.49 1.63e-21 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs7605827 0.930 rs13024104 chr2:15603346 T/C cg19274914 chr2:15703543 NA 0.39 5.89 0.31 9.47e-9 Educational attainment (years of education); CRC cis rs2073300 0.609 rs6137913 chr20:23357725 C/T cg12062639 chr20:23401060 NAPB 0.61 6.21 0.32 1.57e-9 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs11098699 0.821 rs4833891 chr4:124231454 A/G cg09941581 chr4:124220074 SPATA5 0.4 5.88 0.31 1.02e-8 Mosquito bite size; CRC cis rs7208859 0.623 rs56378576 chr17:29010120 C/T cg14008862 chr17:28927542 LRRC37B2 0.59 5.77 0.3 1.87e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs6484504 0.532 rs2616799 chr11:31319044 T/C cg14844989 chr11:31128820 NA 0.36 6.29 0.33 1.01e-9 Red blood cell count; CRC cis rs2836950 0.565 rs3171465 chr21:40552307 A/G cg11644478 chr21:40555479 PSMG1 -0.49 -7.38 -0.38 1.29e-12 Menarche (age at onset); CRC cis rs7113874 0.524 rs10743076 chr11:8560571 C/A cg20771178 chr11:8615675 STK33 -0.35 -5.85 -0.31 1.18e-8 Body mass index in physically active individuals;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs6580649 1.000 rs3825404 chr12:48399931 A/G cg05342945 chr12:48394962 COL2A1 -0.46 -6.41 -0.33 5.14e-10 Lung cancer; CRC cis rs6496667 0.779 rs16944518 chr15:91035084 A/C cg04176472 chr15:90893244 GABARAPL3 0.51 7.41 0.38 1.08e-12 Rheumatoid arthritis; CRC cis rs10028773 0.556 rs4473640 chr4:120260437 G/A cg24375607 chr4:120327624 NA 0.47 7.68 0.39 1.83e-13 Educational attainment; CRC cis rs773506 0.628 rs4743820 chr9:93928416 C/T cg14446406 chr9:93919335 NA -0.45 -7.71 -0.39 1.49e-13 Type 2 diabetes nephropathy; CRC cis rs1577917 0.883 rs6454505 chr6:86592362 G/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.45 -5.95 -0.31 7.01e-9 Response to antipsychotic treatment; CRC cis rs798554 0.757 rs1182181 chr7:2873247 C/G cg17321639 chr7:2759063 NA -0.53 -7.09 -0.36 8.15e-12 Height; CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg01861096 chr22:19279212 CLTCL1 0.39 6.17 0.32 1.99e-9 Obesity-related traits; CRC cis rs892961 0.932 rs3987885 chr17:75414990 A/G cg05865280 chr17:75406074 SEPT9 0.62 13.76 0.6 2.39e-34 Airflow obstruction; CRC trans rs10504229 1.000 rs17217082 chr8:58180918 G/A cg04077850 chr5:125800366 GRAMD3 0.37 6.27 0.33 1.15e-9 Developmental language disorder (linguistic errors); CRC cis rs2576037 0.583 rs8086286 chr18:44467515 A/G cg07416455 chr18:44543612 TCEB3CL;KATNAL2 0.53 7.96 0.4 2.76e-14 Personality dimensions; CRC cis rs3741151 0.773 rs73543000 chr11:73151774 T/C cg17517138 chr11:73019481 ARHGEF17 1.04 8.62 0.43 2.85e-16 GIP levels in response to oral glucose tolerance test (120 minutes); CRC cis rs58904263 1 rs58904263 chr20:30401406 A/AG cg18721089 chr20:30220636 NA -0.37 -5.92 -0.31 8.24e-9 Monocyte count; CRC cis rs992157 0.798 rs7557709 chr2:219167529 G/A cg04731861 chr2:219085781 ARPC2 -0.3 -6.23 -0.32 1.46e-9 Colorectal cancer; CRC cis rs7615952 0.515 rs4267608 chr3:125680500 C/T cg05084668 chr3:125655381 ALG1L -0.65 -10.46 -0.5 2.67e-22 Blood pressure (smoking interaction); CRC cis rs7727544 0.735 rs2569266 chr5:131706791 T/C cg21138405 chr5:131827807 IRF1 0.32 5.69 0.3 2.87e-8 Blood metabolite levels; CRC cis rs10193935 1.000 rs10210866 chr2:42387879 A/G cg27598129 chr2:42591480 NA -0.62 -7.19 -0.37 4.34e-12 Colonoscopy-negative controls vs population controls; CRC cis rs7178572 0.539 rs16968809 chr15:77672118 C/T cg22256960 chr15:77711686 NA 0.61 7.29 0.37 2.3e-12 Type 2 diabetes; CRC cis rs10857712 0.703 rs1056521 chr10:135235890 T/C cg19904058 chr10:135279010 LOC619207 -0.35 -6.81 -0.35 4.71e-11 Systemic lupus erythematosus; CRC cis rs10493773 0.775 rs12564080 chr1:86196586 A/C cg17807903 chr1:86174739 ZNHIT6 -0.53 -11.95 -0.55 1.4e-27 Urate levels in overweight individuals; CRC cis rs2257205 0.667 rs6503884 chr17:56940026 G/A cg25885038 chr17:56607967 SEPT4 -0.53 -5.82 -0.31 1.43e-8 Pancreatic cancer; CRC trans rs637571 0.780 rs653914 chr11:65676516 A/G cg17712092 chr4:129076599 LARP1B 0.96 18.06 0.71 3.96e-51 Eosinophil percentage of white cells; CRC cis rs853679 0.517 rs9393885 chr6:28050009 A/T cg02683197 chr6:28174875 NA 0.8 10.0 0.48 9.7e-21 Depression; CRC cis rs10901296 0.660 rs11789055 chr9:133766295 T/C cg01000188 chr9:133769184 QRFP 0.72 9.15 0.45 5.92e-18 Bilirubin levels; CRC cis rs13064447 0.874 rs9310408 chr3:12757726 T/C cg07775309 chr3:12595852 NA -0.36 -5.8 -0.3 1.53e-8 Major depression and alcohol dependence; CRC cis rs68170813 0.559 rs75007274 chr7:106814543 G/A cg02696742 chr7:106810147 HBP1 -0.62 -6.81 -0.35 4.67e-11 Coronary artery disease; CRC cis rs2717559 0.683 rs2717611 chr8:143879927 C/T cg22687807 chr8:143858763 LYNX1 -0.54 -9.74 -0.47 7.17e-20 Urinary tract infection frequency; CRC cis rs4319547 0.741 rs4758663 chr12:122939483 A/G cg23029597 chr12:123009494 RSRC2 -0.45 -5.91 -0.31 8.47e-9 Body mass index; CRC cis rs8072100 0.688 rs12602134 chr17:45582136 C/G cg08085267 chr17:45401833 C17orf57 0.68 11.31 0.53 2.82e-25 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg16007680 chr8:144349898 GLI4 0.42 6.17 0.32 1.95e-9 Intelligence (multi-trait analysis); CRC cis rs10744422 1.000 rs4759381 chr12:123348480 G/A cg25930673 chr12:123319894 HIP1R -0.61 -5.83 -0.31 1.34e-8 Schizophrenia; CRC trans rs11098499 0.863 rs10009626 chr4:120470005 T/C cg25214090 chr10:38739885 LOC399744 0.65 10.43 0.5 3.37e-22 Corneal astigmatism; CRC cis rs9435341 0.965 rs1762485 chr1:107625056 C/T cg14671364 chr1:107599128 PRMT6 -0.58 -7.88 -0.4 4.99e-14 Facial morphology (factor 21, depth of nasal alae); CRC cis rs4731207 0.596 rs6466968 chr7:124583357 C/T cg23710748 chr7:124431027 NA 0.39 6.37 0.33 6.5e-10 Cutaneous malignant melanoma; CRC cis rs977987 0.806 rs11860284 chr16:75412907 A/G cg03315344 chr16:75512273 CHST6 0.53 8.85 0.44 5.48e-17 Dupuytren's disease; CRC cis rs2404602 0.684 rs57682236 chr15:76868478 G/A cg23625390 chr15:77176239 SCAPER -0.86 -13.74 -0.6 2.76e-34 Blood metabolite levels; CRC cis rs9894429 0.634 rs9709130 chr17:79583948 C/T cg18240062 chr17:79603768 NPLOC4 0.48 7.61 0.39 2.98e-13 Eye color traits; CRC cis rs1059312 1.000 rs9738216 chr12:129281788 C/T cg21616243 chr12:129299702 MGC16384;SLC15A4 -0.67 -11.1 -0.52 1.52e-24 Systemic lupus erythematosus; CRC cis rs1401999 0.606 rs7644687 chr3:183753353 A/G cg05044414 chr3:183734942 ABCC5 0.47 7.52 0.38 5.17e-13 Anterior chamber depth; CRC cis rs422249 0.547 rs174536 chr11:61551927 A/C cg00603274 chr11:61596626 FADS2 -0.46 -6.65 -0.34 1.2e-10 Trans fatty acid levels; CRC cis rs992157 0.835 rs4674283 chr2:219144254 G/A cg04731861 chr2:219085781 ARPC2 0.33 6.95 0.36 2.01e-11 Colorectal cancer; CRC cis rs7447593 0.626 rs3812036 chr5:176813404 C/T cg14427527 chr5:176793960 RGS14 0.38 5.64 0.3 3.75e-8 Urinary electrolytes (magnesium/calcium ratio); CRC cis rs752010 0.806 rs11210500 chr1:42089737 A/G cg06885757 chr1:42089581 HIVEP3 0.51 9.2 0.45 4.18e-18 Lupus nephritis in systemic lupus erythematosus; CRC cis rs738321 0.794 rs6001026 chr22:38545363 C/T cg25457927 chr22:38595422 NA -0.32 -6.28 -0.33 1.07e-9 Breast cancer; CRC cis rs1465370 0.533 rs10239342 chr7:130009312 T/G cg03229158 chr7:130009420 NA 0.5 7.16 0.37 5.23e-12 Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction);Waist circumference adjusted for BMI in active individuals;Waist circumference adjusted for body mass index; CRC cis rs11758351 0.866 rs2069019 chr6:26205604 C/T cg01420254 chr6:26195488 NA 0.8 8.79 0.44 8.31e-17 Gout;Renal underexcretion gout; CRC cis rs10256972 0.706 rs4285396 chr7:1123738 A/G cg27094323 chr7:1216898 NA -0.4 -6.39 -0.33 5.71e-10 Longevity;Endometriosis; CRC cis rs10504229 0.683 rs7000349 chr8:58114569 C/A cg02290350 chr8:58132656 NA -0.58 -8.24 -0.41 4.09e-15 Developmental language disorder (linguistic errors); CRC trans rs6550704 0.687 rs9865314 chr3:22634337 A/G cg14290451 chr6:35436136 RPL10A -0.44 -6.46 -0.34 3.73e-10 Daytime sleep phenotypes; CRC cis rs7811142 0.720 rs7795656 chr7:99950297 A/T cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.73 10.0 0.48 1.02e-20 Platelet count; CRC trans rs12599106 0.792 rs12597352 chr16:34638507 A/T cg01171360 chr6:293285 DUSP22 -0.45 -6.49 -0.34 3.17e-10 Menopause (age at onset); CRC cis rs7618915 0.501 rs6804145 chr3:52694198 C/T cg11645453 chr3:52864694 ITIH4 0.37 6.6 0.34 1.68e-10 Bipolar disorder; CRC cis rs7666738 0.830 rs2114426 chr4:98933130 C/T cg17366294 chr4:99064904 C4orf37 0.43 7.32 0.37 1.95e-12 Colonoscopy-negative controls vs population controls; CRC cis rs62229266 0.771 rs7277791 chr21:37383227 C/A cg12218747 chr21:37451666 NA -0.41 -7.14 -0.37 5.85e-12 Mitral valve prolapse; CRC cis rs11758351 1.000 rs16891401 chr6:26202337 G/A cg22723502 chr6:26240528 HIST1H4F -0.38 -5.85 -0.31 1.22e-8 Gout;Renal underexcretion gout; CRC cis rs12983728 0.831 rs79222418 chr19:58664418 T/C cg21877656 chr19:58662188 ZNF329 0.66 7.2 0.37 4.23e-12 Cholesterol, total; CRC cis rs1577917 0.958 rs16876530 chr6:86595641 T/A cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.51 -6.88 -0.35 3.05e-11 Response to antipsychotic treatment; CRC cis rs6831352 0.734 rs1311620 chr4:100013091 C/T cg13256891 chr4:100009986 ADH5 0.57 7.95 0.4 3.07e-14 Alcohol dependence; CRC trans rs6693295 0.729 rs2185073 chr1:246213341 G/A cg08881680 chr11:94965469 SESN3 0.49 6.02 0.31 4.7e-9 Migraine - clinic-based;Migraine with aura; CRC cis rs6120849 0.754 rs3746446 chr20:33574765 T/C cg24642439 chr20:33292090 TP53INP2 0.44 5.68 0.3 3.02e-8 Protein C levels; CRC cis rs453301 0.686 rs6748 chr8:8890802 C/T cg06636001 chr8:8085503 FLJ10661 -0.47 -7.09 -0.36 7.99e-12 Joint mobility (Beighton score); CRC cis rs916888 0.821 rs199525 chr17:44847834 T/G cg01570182 chr17:44337453 NA 1.28 14.22 0.62 4.24e-36 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs1030268 0.962 rs12707122 chr7:133517309 A/C cg03336402 chr7:133662267 EXOC4 -0.51 -6.77 -0.35 5.75e-11 Intelligence (multi-trait analysis); CRC cis rs4363385 0.588 rs12079087 chr1:153023888 T/C cg25856811 chr1:152973957 SPRR3 -0.23 -6.16 -0.32 2.13e-9 Inflammatory skin disease; CRC cis rs7264396 0.676 rs6058380 chr20:34552900 T/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.61 -9.86 -0.48 2.94e-20 Total cholesterol levels; CRC cis rs4658101 0.700 rs6604045 chr1:92051755 C/T cg24006770 chr1:92056542 NA 0.45 6.61 0.34 1.53e-10 Optic disc area;Vertical cup-disc ratio; CRC cis rs35306767 0.903 rs11253492 chr10:936873 T/C cg26597838 chr10:835615 NA 0.95 11.45 0.53 8.78e-26 Eosinophil percentage of granulocytes; CRC trans rs208520 0.909 rs60604603 chr6:67022955 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.83 9.86 0.48 2.82e-20 Exhaled nitric oxide output; CRC trans rs7615952 0.546 rs111812401 chr3:125361495 G/A cg02560186 chr11:3602584 NA -0.56 -7.1 -0.36 7.58e-12 Blood pressure (smoking interaction); CRC cis rs2839186 0.605 rs2839170 chr21:47671305 A/G cg12516959 chr21:47718080 NA -0.34 -5.68 -0.3 3.03e-8 Testicular germ cell tumor; CRC cis rs1949733 0.554 rs4259044 chr4:8536188 A/G cg11789530 chr4:8429930 ACOX3 -0.43 -6.2 -0.32 1.72e-9 Response to antineoplastic agents; CRC cis rs9992667 0.955 rs6819274 chr4:38615927 A/G cg19726192 chr4:38663646 FLJ13197 -0.57 -7.33 -0.37 1.81e-12 Eosinophil percentage of granulocytes; CRC cis rs17826219 0.636 rs8080829 chr17:29058730 C/T cg01831904 chr17:28903510 LRRC37B2 -0.62 -6.29 -0.33 9.82e-10 Body mass index; CRC cis rs4285028 0.948 rs12630486 chr3:121685267 C/T cg20356878 chr3:121714668 ILDR1 -0.48 -6.95 -0.36 1.93e-11 Multiple sclerosis; CRC cis rs6732160 0.588 rs2043099 chr2:73374156 G/A cg01422370 chr2:73384389 NA 0.37 5.78 0.3 1.74e-8 Intelligence (multi-trait analysis); CRC trans rs9929218 0.953 rs11075696 chr16:68731365 A/G cg04657470 chr2:198365150 HSPE1;HSPD1 -1.0 -14.82 -0.63 1.99e-38 Colorectal cancer; CRC cis rs4862750 0.832 rs9995958 chr4:187901764 G/A cg03452623 chr4:187889614 NA -0.92 -22.45 -0.78 2.37e-68 Lobe attachment (rater-scored or self-reported); CRC cis rs7209700 0.547 rs11657517 chr17:45343713 C/T cg17185639 chr17:45330862 ITGB3 0.4 6.0 0.31 5.34e-9 IgG glycosylation; CRC cis rs12926788 0.542 rs6497759 chr16:24801737 G/A cg06505273 chr16:24850292 NA 0.49 6.17 0.32 1.98e-9 Ejection fraction in Tripanosoma cruzi seropositivity; CRC trans rs10858396 1.000 rs11789484 chr9:138275572 G/T cg26979339 chr12:107168153 RIC8B 0.46 6.02 0.31 4.71e-9 Attention deficit hyperactivity disorder; CRC cis rs7647973 0.961 rs10154992 chr3:49276077 C/T cg20833759 chr3:49053208 WDR6;DALRD3 0.53 8.13 0.41 8.68e-15 Menarche (age at onset); CRC cis rs736408 0.505 rs2083180 chr3:52668119 G/T cg11645453 chr3:52864694 ITIH4 0.36 6.49 0.34 3.17e-10 Bipolar disorder; CRC cis rs9443645 0.901 rs1538233 chr6:79743735 G/T cg11833968 chr6:79620685 NA -0.35 -6.07 -0.32 3.52e-9 Intelligence (multi-trait analysis); CRC cis rs7618915 0.501 rs34157897 chr3:52716937 T/C cg15147215 chr3:52552868 STAB1 -0.65 -11.12 -0.52 1.31e-24 Bipolar disorder; CRC cis rs9533799 1.000 rs7999059 chr13:44807194 C/A cg19190762 chr13:44806055 NA 0.62 9.49 0.46 4.7e-19 Amyotrophic lateral sclerosis; CRC cis rs2811415 0.597 rs3774797 chr3:127772793 G/A cg13719885 chr3:127795394 NA -0.4 -6.05 -0.32 3.83e-9 Lung function (FEV1/FVC); CRC cis rs7811142 1.000 rs1073 chr7:100031612 G/A cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.18 16.92 0.68 1.24e-46 Platelet count; CRC cis rs6676180 0.555 rs12060730 chr1:119770702 A/G cg05756136 chr1:119680316 WARS2 -0.44 -6.61 -0.34 1.57e-10 Monobrow; CRC cis rs9303280 0.806 rs12232497 chr17:38040119 T/C cg17344932 chr17:38183730 MED24;SNORD124 0.37 5.93 0.31 7.47e-9 Self-reported allergy; CRC cis rs12908161 0.920 rs35738019 chr15:85280210 T/C cg17507749 chr15:85114479 UBE2QP1 0.65 9.55 0.47 2.98e-19 Schizophrenia; CRC cis rs12545109 1.000 rs12545109 chr8:57313906 A/C cg09654669 chr8:57350985 NA -0.45 -7.16 -0.37 5.45e-12 Obesity-related traits; CRC cis rs1267303 0.642 rs3737740 chr1:47000596 G/A cg25110126 chr1:46999211 NA 0.6 8.62 0.43 2.93e-16 Monobrow; CRC cis rs9916302 0.904 rs11078915 chr17:37715426 T/C cg07936489 chr17:37558343 FBXL20 -0.86 -13.75 -0.6 2.73e-34 Glomerular filtration rate (creatinine); CRC cis rs1448094 0.520 rs12304244 chr12:86272823 C/T cg18827107 chr12:86230957 RASSF9 -0.47 -7.47 -0.38 7.31e-13 Major depressive disorder; CRC cis rs694739 0.628 rs645078 chr11:64135298 A/C cg02228329 chr11:64053129 BAD;GPR137 0.52 7.16 0.37 5.15e-12 Alopecia areata;Crohn's disease;Psoriasis vulgaris; CRC cis rs9287719 0.649 rs7589694 chr2:10700874 T/C cg00105475 chr2:10696890 NA 0.45 7.04 0.36 1.15e-11 Prostate cancer; CRC cis rs6951245 0.554 rs79367977 chr7:1152657 G/A cg18402987 chr7:1209562 NA 0.56 6.82 0.35 4.43e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC trans rs72956618 1.000 rs28564588 chr2:207496342 G/A cg20754261 chr2:468330 NA -0.64 -6.09 -0.32 3.09e-9 Tonsillectomy; CRC cis rs10489202 0.632 rs3767476 chr1:168066940 C/T cg24449463 chr1:168025552 DCAF6 -0.56 -8.29 -0.42 2.97e-15 Schizophrenia; CRC cis rs370915 0.578 rs1367934 chr4:187776396 A/G cg12892747 chr4:187813459 NA -0.55 -7.92 -0.4 3.77e-14 Gout; CRC cis rs11792861 0.926 rs17628095 chr9:111889172 A/G cg05043794 chr9:111880884 C9orf5 0.31 5.73 0.3 2.29e-8 Menarche (age at onset); CRC cis rs2228479 0.702 rs17233868 chr16:89803629 C/T cg19635926 chr16:89946313 TCF25 0.68 6.15 0.32 2.2e-9 Skin colour saturation; CRC cis rs4662945 0.603 rs10168574 chr2:130267823 C/T cg05962382 chr2:130345044 NA -0.48 -8.31 -0.42 2.46e-15 Response to cytidine analogues (gemcitabine); CRC cis rs11585357 0.947 rs72646789 chr1:17610030 C/T cg08277548 chr1:17600880 PADI3 -0.9 -11.24 -0.53 5.03e-25 Hair shape; CRC cis rs6952808 0.689 rs871924 chr7:2047845 A/G cg04267008 chr7:1944627 MAD1L1 -0.7 -10.09 -0.49 4.78e-21 Bipolar disorder and schizophrenia; CRC cis rs6696846 0.791 rs10158848 chr1:205061192 C/T cg00857998 chr1:205179979 DSTYK 0.46 6.23 0.32 1.4e-9 Red blood cell count; CRC cis rs9911578 1.000 rs302840 chr17:56673079 C/G cg05425664 chr17:57184151 TRIM37 -0.52 -8.21 -0.41 5.21e-15 Intelligence (multi-trait analysis); CRC cis rs96067 0.711 rs737381 chr1:36621186 G/C cg25304816 chr1:36627734 MAP7D1 0.47 6.85 0.35 3.74e-11 Corneal structure; CRC cis rs2882667 0.931 rs10077796 chr5:138356775 A/C cg09476006 chr5:138032270 NA -0.45 -7.33 -0.37 1.79e-12 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs10512697 1.000 rs35237876 chr5:3546147 A/T cg19473799 chr5:3511975 NA -0.76 -5.94 -0.31 7.41e-9 Immune response to smallpox vaccine (IL-6); CRC trans rs4650994 0.525 rs2493865 chr1:178545016 G/A cg05059571 chr16:84539110 KIAA1609 0.57 7.97 0.4 2.69e-14 HDL cholesterol levels;HDL cholesterol; CRC cis rs11997175 0.583 rs4386938 chr8:33673156 A/G ch.8.33884649F chr8:33765107 NA 0.43 6.38 0.33 6.1e-10 Body mass index; CRC cis rs9311676 0.656 rs62258081 chr3:58367705 A/C cg06643156 chr3:58380774 PXK 0.42 6.55 0.34 2.25e-10 Systemic lupus erythematosus; CRC cis rs35306767 0.903 rs12763396 chr10:927357 C/A cg26597838 chr10:835615 NA 0.95 11.66 0.54 1.57e-26 Eosinophil percentage of granulocytes; CRC cis rs6570726 0.935 rs9390329 chr6:145828026 T/C cg13319975 chr6:146136371 FBXO30 -0.38 -5.8 -0.3 1.53e-8 Lobe attachment (rater-scored or self-reported); CRC cis rs863345 0.604 rs10797020 chr1:158490324 A/G cg12129480 chr1:158549410 OR10X1 -0.3 -6.25 -0.33 1.25e-9 Pneumococcal bacteremia; CRC cis rs13108904 0.870 rs4974541 chr4:1244037 A/G cg19318889 chr4:1322082 MAEA 0.43 6.56 0.34 2.06e-10 Obesity-related traits; CRC cis rs4665809 0.590 rs2033317 chr2:26477650 G/A cg04944784 chr2:26401820 FAM59B 0.86 11.56 0.54 3.73e-26 Gut microbiome composition (summer); CRC cis rs2949837 0.581 rs1852210 chr7:45994256 C/T cg21268650 chr7:45961089 IGFBP3 0.36 6.16 0.32 2.06e-9 Sitting height ratio; CRC cis rs7937682 0.632 rs57414412 chr11:111769431 G/A cg19812747 chr11:111475976 SIK2 0.44 6.33 0.33 7.9e-10 Primary sclerosing cholangitis; CRC cis rs798554 0.686 rs2527690 chr7:2854250 C/T cg13628971 chr7:2884303 GNA12 0.41 6.31 0.33 9.14e-10 Height; CRC trans rs1728785 1.000 rs1749791 chr16:68572347 C/T cg04657470 chr2:198365150 HSPE1;HSPD1 0.58 6.97 0.36 1.72e-11 Ulcerative colitis; CRC cis rs7647973 1.000 rs11719762 chr3:49409002 G/C cg07636037 chr3:49044803 WDR6 0.66 8.27 0.41 3.29e-15 Menarche (age at onset); CRC cis rs2239547 0.523 rs6803486 chr3:53098209 T/A cg15147215 chr3:52552868 STAB1 -0.41 -5.64 -0.3 3.61e-8 Schizophrenia; CRC cis rs2274273 0.870 rs10134339 chr14:55814380 T/C cg23234261 chr14:55582407 NA -0.29 -5.86 -0.31 1.14e-8 Protein biomarker; CRC cis rs9457247 0.765 rs9457252 chr6:167433925 A/G cg23791538 chr6:167370224 RNASET2 0.37 5.71 0.3 2.49e-8 Crohn's disease; CRC cis rs9303280 0.806 rs10445308 chr17:37938047 C/T cg00129232 chr17:37814104 STARD3 -0.45 -7.39 -0.38 1.19e-12 Self-reported allergy; CRC cis rs992157 0.798 rs7557709 chr2:219167529 G/A cg00012203 chr2:219082015 ARPC2 0.45 6.78 0.35 5.62e-11 Colorectal cancer; CRC trans rs4843747 0.636 rs11864872 chr16:88105966 A/G cg26811252 chr16:29126840 RRN3P2 0.61 8.33 0.42 2.16e-15 Menopause (age at onset); CRC cis rs2836974 0.568 rs11910906 chr21:40685662 T/C cg11890956 chr21:40555474 PSMG1 -0.86 -13.72 -0.6 3.39e-34 Cognitive function; CRC cis rs4974559 0.501 rs730830 chr4:1240091 T/C cg02980000 chr4:1222292 CTBP1 -0.73 -8.34 -0.42 2.11e-15 Systolic blood pressure; CRC cis rs1129187 0.755 rs4714638 chr6:42917017 A/G cg21280719 chr6:42927975 GNMT -0.47 -10.34 -0.5 6.76e-22 Alzheimer's disease in APOE e4+ carriers; CRC cis rs709400 0.663 rs2273703 chr14:103918029 C/G cg12935359 chr14:103987150 CKB -0.47 -7.63 -0.39 2.6e-13 Body mass index; CRC cis rs11155671 0.530 rs7758020 chr6:150208111 T/C cg13206674 chr6:150067644 NUP43 0.48 6.95 0.36 1.93e-11 Testicular germ cell tumor; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg20361001 chr2:9563570 ITGB1BP1;CPSF3 0.46 6.01 0.31 4.89e-9 Anxiety disorder; CRC cis rs3093024 0.904 rs3093019 chr6:167539655 C/G cg05540913 chr6:167530185 CCR6 -0.37 -6.77 -0.35 5.76e-11 Rheumatoid arthritis; CRC cis rs2880765 0.835 rs12324277 chr15:86041735 G/A cg17133734 chr15:86042851 AKAP13 0.42 6.72 0.35 7.92e-11 Coronary artery disease; CRC cis rs8099014 0.814 rs7227488 chr18:56113233 A/G cg12907477 chr18:56117327 MIR122 0.47 5.95 0.31 6.74e-9 Platelet count; CRC cis rs798554 1.000 rs798545 chr7:2762386 C/T cg19717773 chr7:2847554 GNA12 -0.44 -6.58 -0.34 1.89e-10 Height; CRC trans rs853679 0.699 rs9468318 chr6:28209531 T/A cg06606381 chr12:133084897 FBRSL1 -0.65 -6.7 -0.35 8.99e-11 Depression; CRC cis rs1883415 0.750 rs2076317 chr6:24490147 A/G cg20631270 chr6:24437470 GPLD1 0.39 5.7 0.3 2.73e-8 Liver enzyme levels (alkaline phosphatase); CRC cis rs34779708 0.931 rs1926554 chr10:35344969 C/T cg03585969 chr10:35415529 CREM 0.65 8.64 0.43 2.46e-16 Inflammatory bowel disease;Crohn's disease; CRC cis rs6918586 0.658 rs198825 chr6:26122502 A/G cg18357526 chr6:26021779 HIST1H4A -0.51 -7.7 -0.39 1.62e-13 Schizophrenia; CRC cis rs2836974 0.897 rs8132568 chr21:40527916 C/T cg11644478 chr21:40555479 PSMG1 0.82 13.53 0.6 1.81e-33 Cognitive function; CRC cis rs10504229 1.000 rs60454728 chr8:58173781 G/A cg02290350 chr8:58132656 NA -0.42 -5.96 -0.31 6.62e-9 Developmental language disorder (linguistic errors); CRC trans rs11088226 0.581 rs2236430 chr21:33973408 A/G cg09050820 chr6:167586206 TCP10L2 -0.6 -8.12 -0.41 9.79e-15 Gastritis; CRC cis rs10256972 0.552 rs6978842 chr7:1204599 A/C cg27094323 chr7:1216898 NA -0.43 -7.33 -0.37 1.82e-12 Longevity;Endometriosis; CRC cis rs853679 0.517 rs4713144 chr6:28106790 C/G cg12963246 chr6:28129442 ZNF389 0.49 5.78 0.3 1.73e-8 Depression; CRC cis rs7584330 0.868 rs58057291 chr2:238395479 T/A cg11271282 chr2:238384023 NA 0.47 5.74 0.3 2.14e-8 Prostate cancer; CRC cis rs2474619 0.562 rs2501721 chr6:90845036 A/G cg06866423 chr6:90926672 BACH2 0.45 7.57 0.38 3.91e-13 Celiac disease; CRC cis rs6089584 0.528 rs881994 chr20:60623931 G/A cg23463467 chr20:60627584 TAF4 0.44 8.34 0.42 2.05e-15 Body mass index; CRC cis rs561341 1.000 rs555629 chr17:30294136 T/C cg12193833 chr17:30244370 NA -0.74 -8.72 -0.43 1.45e-16 Hip circumference adjusted for BMI; CRC cis rs1707322 1.000 rs785467 chr1:46521559 A/T cg03146154 chr1:46216737 IPP -0.58 -7.95 -0.4 2.96e-14 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC trans rs1468498 0.588 rs7350409 chr10:116054585 C/G cg10063575 chr12:53822143 AMHR2 -0.46 -6.0 -0.31 5.24e-9 Left ventricular obstructive tract defect (maternal effect); CRC cis rs17818399 0.612 rs4952834 chr2:46777462 C/G cg21681030 chr2:46777652 RHOQ 0.42 6.32 0.33 8.3e-10 Height; CRC cis rs965469 0.779 rs2236121 chr20:3304320 A/G cg25506879 chr20:3388711 C20orf194 -0.4 -5.74 -0.3 2.17e-8 IFN-related cytopenia; CRC cis rs2032447 0.832 rs10425 chr6:26056549 A/G cg04800585 chr6:26043546 HIST1H2BB 0.52 7.83 0.4 6.89e-14 Intelligence (multi-trait analysis); CRC cis rs10256972 0.577 rs4999286 chr7:1199506 C/G cg04025307 chr7:1156635 C7orf50 0.69 11.05 0.52 2.28e-24 Longevity;Endometriosis; CRC trans rs4263408 0.934 rs9683743 chr4:39703194 A/C cg24284087 chr3:184033015 EIF4G1 -0.41 -6.04 -0.32 4.27e-9 Plasma amyloid beta peptide concentrations (ABx-40); CRC cis rs6951245 1.000 rs76804143 chr7:1082021 C/T cg26224354 chr7:1096374 C7orf50;GPR146 -0.89 -11.19 -0.53 7.61e-25 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs58688157 0.705 rs12419720 chr11:598205 C/G cg11503833 chr11:492997 NA 0.44 5.66 0.3 3.31e-8 Systemic lupus erythematosus; CRC cis rs3126085 0.935 rs4845734 chr1:152167473 T/C cg09127314 chr1:152161683 NA 0.49 6.15 0.32 2.29e-9 Atopic dermatitis; CRC cis rs9931543 0.504 rs4784650 chr16:56306640 A/G cg02433656 chr16:56322654 GNAO1 0.47 7.15 0.37 5.5e-12 Subjective well-being; CRC cis rs11628318 0.515 rs9324049 chr14:103096352 T/C cg12046867 chr14:103022105 NA -0.41 -5.62 -0.3 4.02e-8 Platelet count; CRC cis rs1577917 1.000 rs955197 chr6:86729675 G/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.52 -6.53 -0.34 2.57e-10 Response to antipsychotic treatment; CRC cis rs2576037 0.583 rs8086286 chr18:44467515 A/G cg19077165 chr18:44547161 KATNAL2 0.62 10.24 0.49 1.49e-21 Personality dimensions; CRC cis rs9303280 0.806 rs12936409 chr17:38043649 C/T cg17344932 chr17:38183730 MED24;SNORD124 0.37 5.92 0.31 7.88e-9 Self-reported allergy; CRC cis rs2463822 0.764 rs7125402 chr11:62097259 C/T cg06239285 chr11:62104954 ASRGL1 0.97 11.38 0.53 1.58e-25 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs425277 0.583 rs4648807 chr1:2040898 A/G cg03732007 chr1:2071316 PRKCZ -0.36 -5.72 -0.3 2.39e-8 Height; CRC cis rs6951245 1.000 rs75488469 chr7:1102122 A/G cg03188948 chr7:1209495 NA 0.64 6.79 0.35 5.15e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs6496667 0.779 rs719473 chr15:90998064 A/G cg04176472 chr15:90893244 GABARAPL3 0.58 8.3 0.42 2.82e-15 Rheumatoid arthritis; CRC cis rs6840360 0.582 rs4696259 chr4:152310788 A/G cg09659197 chr4:152720779 NA 0.31 5.96 0.31 6.62e-9 Intelligence (multi-trait analysis); CRC cis rs1348850 0.574 rs4893835 chr2:178442592 T/C cg27490568 chr2:178487706 NA 0.5 6.49 0.34 3.13e-10 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs3733585 0.699 rs2018643 chr4:9947121 C/T cg00071950 chr4:10020882 SLC2A9 0.55 9.8 0.48 4.71e-20 Cleft plate (environmental tobacco smoke interaction); CRC cis rs939584 1.000 rs13415094 chr2:653093 T/C cg03610516 chr2:642275 NA -0.43 -5.93 -0.31 7.78e-9 Body mass index; CRC cis rs6951245 1.000 rs78523927 chr7:1089458 T/C cg04025307 chr7:1156635 C7orf50 0.64 6.66 0.34 1.16e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs8060686 0.641 rs75450962 chr16:68210868 C/T cg08314208 chr16:67682810 RLTPR -0.54 -5.94 -0.31 7.18e-9 HDL cholesterol;Metabolic syndrome; CRC cis rs514406 0.505 rs269293 chr1:53187767 A/C cg27535305 chr1:53392650 SCP2 -0.34 -6.08 -0.32 3.26e-9 Monocyte count; CRC cis rs4654899 1.000 rs7550267 chr1:21448792 T/C cg02927042 chr1:21476669 EIF4G3 -0.5 -8.1 -0.41 1.09e-14 Superior frontal gyrus grey matter volume; CRC cis rs56235845 0.964 rs11746443 chr5:176798306 G/A cg06060754 chr5:176797920 RGS14 0.74 11.19 0.53 7.61e-25 Hemoglobin concentration;Hematocrit; CRC cis rs7927592 0.830 rs7120635 chr11:68261293 A/G cg01657329 chr11:68192670 LRP5 -0.48 -7.42 -0.38 1.02e-12 Total body bone mineral density; CRC cis rs9303542 0.559 rs12939811 chr17:46607958 A/T cg04904318 chr17:46607828 HOXB1 -0.55 -6.55 -0.34 2.2e-10 Ovarian cancer;Epithelial ovarian cancer; CRC cis rs7149337 0.869 rs7159770 chr14:51691835 G/A cg18683604 chr14:51561293 TRIM9 0.29 5.66 0.3 3.25e-8 Cancer; CRC cis rs798554 0.959 rs798558 chr7:2758935 T/G cg13628971 chr7:2884303 GNA12 0.47 6.44 0.33 4.21e-10 Height; CRC cis rs11098499 0.909 rs35165976 chr4:120325630 G/A cg09307838 chr4:120376055 NA 0.71 11.04 0.52 2.62e-24 Corneal astigmatism; CRC trans rs11039571 0.544 rs7947811 chr11:48167738 C/T cg03929089 chr4:120376271 NA -0.67 -7.18 -0.37 4.75e-12 D-dimer levels; CRC cis rs910316 1.000 rs28626045 chr14:75589195 G/C cg08847533 chr14:75593920 NEK9 0.93 18.14 0.71 1.87e-51 Height; CRC cis rs289828 0.868 rs289832 chr2:152134405 G/C cg06191203 chr2:152266755 RIF1 -0.4 -5.68 -0.3 2.91e-8 Blood protein levels; CRC cis rs13191362 1.000 rs34398656 chr6:162999612 G/T cg06582575 chr6:163149167 PACRG;PARK2 0.74 10.67 0.51 5.17e-23 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC trans rs6951245 1.000 rs78861357 chr7:1095418 C/T cg13565492 chr6:43139072 SRF -0.71 -7.38 -0.38 1.32e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs7811142 0.943 rs11769886 chr7:99998607 G/A cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.13 14.94 0.64 6.99e-39 Platelet count; CRC cis rs2408955 0.521 rs1476607 chr12:48524804 A/G cg24011408 chr12:48396354 COL2A1 -0.45 -6.46 -0.34 3.79e-10 Glycated hemoglobin levels; CRC cis rs748404 0.560 rs529611 chr15:43805988 T/C cg02155558 chr15:43621948 ADAL;LCMT2 0.52 7.49 0.38 6.38e-13 Lung cancer; CRC cis rs1801251 1.000 rs7592717 chr2:233577038 G/A cg25237894 chr2:233734115 C2orf82 0.52 8.21 0.41 5.21e-15 Coronary artery disease; CRC cis rs9388451 0.839 rs10457469 chr6:126083658 G/A cg05901451 chr6:126070800 HEY2 -0.66 -11.45 -0.53 8.91e-26 Brugada syndrome; CRC cis rs7085104 0.727 rs12773892 chr10:104631177 G/T cg04362960 chr10:104952993 NT5C2 0.89 8.49 0.42 7.16e-16 Immature fraction of reticulocytes;Schizophrenia; CRC cis rs7666738 0.830 rs7664051 chr4:98766970 C/G cg05340658 chr4:99064831 C4orf37 0.54 7.9 0.4 4.36e-14 Colonoscopy-negative controls vs population controls; CRC trans rs1814175 0.647 rs28456013 chr11:50047629 T/C cg15704280 chr7:45808275 SEPT13 -0.76 -12.21 -0.56 1.58e-28 Height; CRC cis rs6662572 0.737 rs56295206 chr1:46551026 G/A cg03123370 chr1:45965343 CCDC163P;MMACHC 0.47 5.94 0.31 7.26e-9 Blood protein levels; CRC cis rs11676348 0.791 rs6726126 chr2:218952233 G/A cg00012203 chr2:219082015 ARPC2 -0.42 -6.17 -0.32 2.04e-9 Ulcerative colitis; CRC cis rs1799949 0.965 rs8176322 chr17:41195773 A/G cg25072359 chr17:41440525 NA 0.45 6.86 0.35 3.34e-11 Menopause (age at onset); CRC cis rs7613875 0.620 rs2526747 chr3:50082914 C/G cg05623727 chr3:50126028 RBM5 0.61 10.51 0.5 1.86e-22 Body mass index; CRC cis rs9818758 0.607 rs35673421 chr3:49139406 G/A cg07636037 chr3:49044803 WDR6 -0.75 -6.21 -0.32 1.63e-9 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; CRC cis rs4563143 0.514 rs73029079 chr19:29294903 A/G cg12667521 chr19:29218732 NA 0.52 7.16 0.37 5.18e-12 Methadone dose in opioid dependence; CRC cis rs7917772 0.636 rs7069489 chr10:104525371 A/G cg04362960 chr10:104952993 NT5C2 -0.44 -5.88 -0.31 9.86e-9 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC cis rs644799 0.710 rs10831429 chr11:95508524 C/A cg25478527 chr11:95522999 CEP57;FAM76B 0.5 7.57 0.39 3.74e-13 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC trans rs2727020 0.538 rs61885230 chr11:49128958 T/C cg00717180 chr2:96193071 NA -0.41 -6.84 -0.35 3.96e-11 Coronary artery disease; CRC cis rs7626444 0.584 rs7633044 chr3:196490643 A/G cg12930392 chr3:196481615 PAK2 0.38 6.82 0.35 4.44e-11 Monocyte count; CRC cis rs9486715 0.867 rs4438964 chr6:96917563 T/G cg06623918 chr6:96969491 KIAA0776 1.01 20.06 0.74 5.16e-59 Headache; CRC cis rs1799949 1.000 rs1973646 chr17:41310495 T/C cg19454999 chr17:41278357 BRCA1;NBR2 0.54 8.28 0.42 3.04e-15 Menopause (age at onset); CRC cis rs9916302 0.752 rs6503513 chr17:37561613 A/G cg15445000 chr17:37608096 MED1 -0.42 -8.53 -0.43 5.46e-16 Glomerular filtration rate (creatinine); CRC trans rs9929218 1.000 rs7200690 chr16:68778457 C/T cg04657470 chr2:198365150 HSPE1;HSPD1 -0.95 -13.65 -0.6 6.37e-34 Colorectal cancer; CRC cis rs9467711 0.591 rs34351439 chr6:25833010 T/C cg16898833 chr6:26189333 HIST1H4D 0.78 6.52 0.34 2.64e-10 Autism spectrum disorder or schizophrenia; CRC cis rs9902453 0.765 rs2628185 chr17:28070107 G/A cg26525008 chr17:28256777 EFCAB5;SSH2 -0.72 -12.04 -0.55 6.79e-28 Coffee consumption (cups per day); CRC trans rs1814175 0.817 rs12295885 chr11:50036762 T/G cg15704280 chr7:45808275 SEPT13 -0.97 -19.11 -0.73 2.72e-55 Height; CRC cis rs617791 0.508 rs10896074 chr11:65776304 C/T cg27068330 chr11:65405492 SIPA1 -0.48 -6.55 -0.34 2.24e-10 Breast cancer; CRC cis rs4969178 0.896 rs1976704 chr17:76401318 C/T cg20026190 chr17:76395443 PGS1 0.38 5.71 0.3 2.54e-8 HDL cholesterol levels; CRC cis rs4713118 0.513 rs149897 chr6:28006650 A/G cg15786705 chr6:28176104 NA 0.59 8.66 0.43 2.17e-16 Parkinson's disease; CRC cis rs4144743 0.759 rs34251886 chr17:45320299 G/T cg18085866 chr17:45331354 ITGB3 -0.52 -6.02 -0.31 4.73e-9 Body mass index; CRC trans rs3808502 0.526 rs11783065 chr8:11417257 A/G cg06636001 chr8:8085503 FLJ10661 -0.51 -7.68 -0.39 1.79e-13 Neuroticism; CRC trans rs7726839 0.540 rs72703087 chr5:598029 C/T cg25482853 chr8:67687455 SGK3 1.1 12.97 0.58 2.42e-31 Obesity-related traits; CRC cis rs2739330 0.627 rs9608219 chr22:24274119 G/C cg18538332 chr22:24372958 LOC391322 -0.69 -10.75 -0.51 2.57e-23 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs9942416 0.660 rs41534344 chr5:74997832 T/C cg19683494 chr5:74908142 NA 0.48 6.2 0.32 1.74e-9 Age-related disease endophenotypes; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg12998533 chr5:43514915 C5orf34 0.45 6.26 0.33 1.22e-9 Response to antipsychotic treatment; CRC cis rs2530545 0.762 rs10245143 chr7:34667302 C/T cg14401837 chr7:34697493 NPSR1 0.42 6.09 0.32 3.13e-9 IgG glycosylation; CRC cis rs3741798 1.000 rs78807762 chr12:12484136 G/A cg08615371 chr12:12503544 MANSC1 1.04 8.83 0.44 6.15e-17 Cerebrospinal fluid biomarker levels; CRC cis rs9368481 0.761 rs9379952 chr6:26987900 A/T cg12292205 chr6:26970375 C6orf41 -0.75 -12.3 -0.56 7.55e-29 Autism spectrum disorder or schizophrenia; CRC cis rs3749237 0.595 rs7637999 chr3:49535115 C/T cg02487422 chr3:49467188 NICN1 0.44 7.06 0.36 9.87e-12 Resting heart rate; CRC trans rs9929218 0.953 rs3118227 chr16:68734855 G/A cg04657470 chr2:198365150 HSPE1;HSPD1 -0.91 -12.18 -0.56 1.96e-28 Colorectal cancer; CRC cis rs2762353 0.595 rs10498728 chr6:25751320 A/T cg07061783 chr6:25882402 NA -0.53 -6.9 -0.36 2.63e-11 Blood metabolite levels; CRC cis rs847649 0.731 rs7785272 chr7:102671023 A/G cg18108683 chr7:102477205 FBXL13 -0.51 -7.85 -0.4 5.94e-14 Morning vs. evening chronotype; CRC cis rs6815814 0.950 rs11727978 chr4:38811051 T/A cg06935464 chr4:38784597 TLR10 0.55 5.69 0.3 2.78e-8 Breast cancer; CRC cis rs11622475 1.000 rs10149651 chr14:104394440 A/G cg20488157 chr14:104394430 TDRD9 -0.68 -9.68 -0.47 1.16e-19 Bipolar disorder; CRC cis rs10450586 0.829 rs7478918 chr11:27295428 G/A cg10370305 chr11:27303972 NA 0.38 6.25 0.33 1.29e-9 Total body bone mineral density; CRC trans rs7267979 1.000 rs6115182 chr20:25410259 G/A cg17903999 chr18:56338584 MALT1 0.42 6.98 0.36 1.6e-11 Liver enzyme levels (alkaline phosphatase); CRC cis rs13256369 0.851 rs13271698 chr8:8567539 C/A cg06671706 chr8:8559999 CLDN23 0.63 9.17 0.45 5.19e-18 Obesity-related traits; CRC cis rs7950696 1 rs7950696 chr11:47481533 T/C cg20307385 chr11:47447363 PSMC3 0.54 7.9 0.4 4.19e-14 Platelet count; CRC cis rs6951245 0.938 rs78351779 chr7:1097023 G/C cg18402987 chr7:1209562 NA 0.67 7.15 0.37 5.54e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs6701037 0.748 rs2685 chr1:175127771 A/G cg17845761 chr1:175162550 KIAA0040 0.27 5.63 0.3 3.78e-8 Alcohol dependence; CRC cis rs13253111 0.624 rs4732844 chr8:28104473 A/G cg26534493 chr8:28060551 NA -0.43 -7.25 -0.37 3.04e-12 Childhood body mass index; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg00108277 chr3:49840710 C3orf54 0.46 6.33 0.33 7.85e-10 Anxiety disorder; CRC cis rs2019137 0.560 rs10206269 chr2:113990393 C/A cg21610815 chr2:113994035 PAX8;LOC654433;LOC440839 0.56 8.17 0.41 6.94e-15 Lymphocyte counts; CRC cis rs951366 0.617 rs823075 chr1:205774897 C/T cg14159672 chr1:205819179 PM20D1 0.93 15.46 0.65 6.71e-41 Menarche (age at onset); CRC cis rs17376456 0.569 rs1349711 chr5:93179032 C/T cg21475434 chr5:93447410 FAM172A -0.46 -5.64 -0.3 3.6e-8 Diabetic retinopathy; CRC cis rs6479527 0.840 rs1411860 chr9:96763932 T/G cg14459158 chr9:96720562 NA 0.41 7.51 0.38 5.64e-13 Esophageal adenocarcinoma; CRC cis rs6456156 0.774 rs2021999 chr6:167529766 G/C cg19688584 chr6:167529678 CCR6 -0.36 -6.45 -0.34 3.92e-10 Primary biliary cholangitis; CRC cis rs7487075 0.930 rs4768121 chr12:46829852 A/G cg22049899 chr12:47219821 SLC38A4 0.31 6.09 0.32 3.12e-9 Itch intensity from mosquito bite; CRC trans rs916888 0.610 rs199529 chr17:44837217 A/C cg10053473 chr17:62856997 LRRC37A3 -0.73 -8.36 -0.42 1.76e-15 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg13057196 chr4:8442503 ACOX3 0.39 6.2 0.32 1.69e-9 Liver disease severity in Alagille syndrome; CRC cis rs12681287 0.647 rs2953510 chr8:87341914 T/C cg27223183 chr8:87520930 FAM82B -0.52 -6.96 -0.36 1.85e-11 Caudate activity during reward; CRC cis rs9910055 0.529 rs408282 chr17:42182267 A/G cg13607699 chr17:42295918 UBTF -0.46 -5.94 -0.31 7.08e-9 Total body bone mineral density; CRC cis rs7119 0.667 rs907392 chr15:77903393 T/C cg10437265 chr15:77819839 NA -0.48 -8.38 -0.42 1.51e-15 Type 2 diabetes; CRC cis rs736408 0.609 rs13082208 chr3:52781539 T/G cg08222913 chr3:52553049 STAB1 -0.34 -6.03 -0.32 4.29e-9 Bipolar disorder; CRC cis rs1862618 0.671 rs2591968 chr5:56233541 A/G cg20203395 chr5:56204925 C5orf35 -0.57 -7.69 -0.39 1.78e-13 Initial pursuit acceleration; CRC cis rs8077889 0.826 rs60085355 chr17:41847415 T/C cg26893861 chr17:41843967 DUSP3 0.89 12.86 0.58 5.87e-31 Triglycerides; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg06937829 chr11:554920 C11orf35 0.42 6.02 0.31 4.6e-9 Intelligence (multi-trait analysis); CRC cis rs4363385 0.818 rs382292 chr1:153006641 G/A cg25856811 chr1:152973957 SPRR3 -0.25 -6.99 -0.36 1.51e-11 Inflammatory skin disease; CRC cis rs2046867 0.862 rs6766747 chr3:72856551 T/C cg25664220 chr3:72788482 NA -0.46 -6.47 -0.34 3.52e-10 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; CRC cis rs7552404 0.590 rs1565717 chr1:76320441 T/C cg05598546 chr1:76251766 SNORD45C;RABGGTB -0.51 -5.83 -0.31 1.33e-8 Blood metabolite levels;Acylcarnitine levels; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg19713609 chr11:819941 PNPLA2 0.36 5.98 0.31 5.85e-9 Liver disease severity in Alagille syndrome; CRC cis rs853679 0.517 rs4713137 chr6:28083521 C/G cg23161317 chr6:28129485 ZNF389 0.54 6.56 0.34 2.12e-10 Depression; CRC cis rs6502050 0.769 rs11658272 chr17:80084596 C/T cg09264619 chr17:80180166 NA 0.36 6.08 0.32 3.4e-9 Life satisfaction; CRC cis rs11711311 0.736 rs2278941 chr3:113350508 A/G cg15478005 chr3:113465772 ATP6V1A;NAA50 0.42 5.74 0.3 2.18e-8 IgG glycosylation; CRC cis rs1223397 1.000 rs1223397 chr6:13270945 C/G cg07912922 chr6:13274314 PHACTR1 0.44 5.66 0.3 3.26e-8 Blood pressure; CRC cis rs1223397 0.938 rs20499 chr6:13295004 C/T cg07912922 chr6:13274314 PHACTR1 0.47 5.83 0.31 1.35e-8 Blood pressure; CRC cis rs9487051 0.676 rs7753697 chr6:109593292 A/G cg12927641 chr6:109611667 NA -0.36 -6.44 -0.33 4.15e-10 Reticulocyte fraction of red cells; CRC cis rs13191362 0.507 rs13197051 chr6:163201728 A/T cg21926612 chr6:163149169 PACRG;PARK2 0.57 8.95 0.44 2.71e-17 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs4713118 0.955 rs9468204 chr6:27688809 C/T cg06470822 chr6:28175283 NA 0.67 8.98 0.44 2.07e-17 Parkinson's disease; CRC cis rs875971 1.000 rs7783613 chr7:65805261 C/T cg11764359 chr7:65958608 NA -0.63 -10.06 -0.49 6.04e-21 Aortic root size; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg12866938 chr5:145583408 RBM27 0.42 6.06 0.32 3.67e-9 Intelligence (multi-trait analysis); CRC cis rs9322193 0.923 rs9372044 chr6:150102003 G/A cg13206674 chr6:150067644 NUP43 0.57 8.14 0.41 8.29e-15 Lung cancer; CRC cis rs10131894 0.611 rs175001 chr14:75436452 A/C cg11812906 chr14:75593930 NEK9 0.49 7.19 0.37 4.5e-12 Coronary artery disease; CRC trans rs7604735 0.824 rs35462154 chr2:145821133 C/A cg26010734 chr19:15344046 EPHX3 -0.35 -6.06 -0.32 3.78e-9 Coronary artery disease; CRC cis rs17767392 0.958 rs4899398 chr14:72083441 A/G cg13720639 chr14:72061746 SIPA1L1 0.56 7.05 0.36 1.07e-11 Mitral valve prolapse; CRC trans rs7580658 0.614 rs7585198 chr2:127962635 C/T cg21827969 chr4:56212299 SRD5A3 -0.48 -6.59 -0.34 1.74e-10 Protein C levels; CRC cis rs2439831 0.850 rs8032649 chr15:44134922 C/T cg02155558 chr15:43621948 ADAL;LCMT2 -0.71 -7.19 -0.37 4.26e-12 Lung cancer in ever smokers; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg18030105 chr11:3396237 ZNF195 -0.38 -6.22 -0.32 1.55e-9 Liver disease severity in Alagille syndrome; CRC cis rs10880689 1 rs10880689 chr12:37930102 A/G cg13010199 chr12:38710504 ALG10B 0.46 6.04 0.32 4.06e-9 Resting heart rate; CRC cis rs10128251 0.847 rs12777965 chr10:5724297 T/C cg24097872 chr10:5724021 NA -0.45 -6.05 -0.32 3.89e-9 Childhood ear infection; CRC trans rs1005277 0.579 rs9299760 chr10:38377920 C/T cg27523141 chr10:43048294 ZNF37B 0.5 7.34 0.38 1.73e-12 Extrinsic epigenetic age acceleration; CRC cis rs9303280 0.618 rs4065986 chr17:38102641 G/A cg24910161 chr17:38119198 GSDMA -0.33 -5.8 -0.3 1.59e-8 Self-reported allergy; CRC cis rs1953600 0.729 rs2819872 chr10:81906269 A/G cg04850286 chr10:81895943 PLAC9 0.37 6.92 0.36 2.35e-11 Sarcoidosis; CRC cis rs56399783 0.901 rs73049327 chr7:2795544 T/G cg19731401 chr7:2775893 GNA12 0.67 7.26 0.37 2.77e-12 Childhood ear infection; CRC trans rs61931739 0.534 rs7302688 chr12:34235064 A/G cg26384229 chr12:38710491 ALG10B 0.54 6.85 0.35 3.62e-11 Morning vs. evening chronotype; CRC cis rs9926296 0.548 rs6500439 chr16:89808275 A/C cg21285383 chr16:89894308 SPIRE2 0.37 6.18 0.32 1.87e-9 Vitiligo; CRC cis rs2985684 0.894 rs4900927 chr14:50018741 G/T cg04989706 chr14:50066350 PPIL5 -0.57 -8.08 -0.41 1.29e-14 Carotid intima media thickness; CRC trans rs11847697 1.000 rs60186497 chr14:30479220 C/T cg01202639 chr12:100898608 NR1H4 0.46 6.11 0.32 2.74e-9 Body mass index; CRC cis rs35306767 0.903 rs12254002 chr10:929133 A/G cg26597838 chr10:835615 NA -0.9 -11.19 -0.52 7.73e-25 Eosinophil percentage of granulocytes; CRC cis rs1153858 0.943 rs12439575 chr15:45684816 T/G cg10760299 chr15:45669010 GATM 0.51 8.02 0.4 1.93e-14 Homoarginine levels; CRC cis rs832540 0.864 rs832576 chr5:56163255 C/A cg18230493 chr5:56204884 C5orf35 -0.38 -5.64 -0.3 3.75e-8 Coronary artery disease; CRC cis rs12200560 0.505 rs1334321 chr6:97079571 C/T cg06623918 chr6:96969491 KIAA0776 -0.51 -7.59 -0.39 3.24e-13 Coronary heart disease; CRC cis rs11650776 1 rs11650776 chr17:37641402 G/A cg00129232 chr17:37814104 STARD3 -0.53 -7.87 -0.4 5.27e-14 Lung function (FEV1); CRC cis rs7945718 0.621 rs7481252 chr11:12681682 A/G cg25843174 chr11:12811716 TEAD1 0.39 7.07 0.36 9.43e-12 Educational attainment (years of education); CRC cis rs7647973 0.925 rs6446257 chr3:49253492 A/G cg07636037 chr3:49044803 WDR6 -0.58 -6.97 -0.36 1.76e-11 Menarche (age at onset); CRC cis rs7617773 0.815 rs9825637 chr3:48372282 T/C cg11946769 chr3:48343235 NME6 0.68 9.18 0.45 4.87e-18 Coronary artery disease; CRC cis rs995000 0.931 rs10889347 chr1:63075826 G/A cg19896129 chr1:63156450 NA 0.42 6.53 0.34 2.48e-10 Triglyceride levels; CRC cis rs644799 0.735 rs10831432 chr11:95516040 C/A cg03916912 chr11:95522834 CEP57;FAM76B 0.86 15.72 0.65 6.39e-42 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs3793917 0.948 rs3750846 chr10:124215565 T/C cg24884230 chr10:124216658 ARMS2 0.36 5.69 0.3 2.88e-8 Age-related macular degeneration; CRC cis rs2179367 0.959 rs4897125 chr6:149766208 G/A cg11245181 chr6:149772854 ZC3H12D -0.43 -6.76 -0.35 6.39e-11 Dupuytren's disease; CRC cis rs1580019 0.563 rs2392071 chr7:32572536 G/A cg07520158 chr7:32535189 LSM5;AVL9 0.53 7.68 0.39 1.82e-13 Cognitive ability; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg10440450 chr16:66642627 CMTM3 0.44 6.3 0.33 9.66e-10 Anxiety disorder; CRC cis rs7618915 0.501 rs6617 chr3:52740182 C/G cg18404041 chr3:52824283 ITIH1 -0.4 -8.28 -0.42 3.04e-15 Bipolar disorder; CRC cis rs651907 0.557 rs11917682 chr3:101355427 G/A cg11279151 chr3:101281821 RG9MTD1 -0.56 -7.67 -0.39 1.9e-13 Colorectal cancer; CRC cis rs6502050 0.835 rs4641801 chr17:80154021 G/A cg25804541 chr17:80189381 SLC16A3 -0.29 -5.66 -0.3 3.38e-8 Life satisfaction; CRC cis rs1048238 0.846 rs945417 chr1:16344625 C/G cg10494257 chr1:16342123 HSPB7 0.4 5.65 0.3 3.51e-8 Systolic blood pressure; CRC cis rs7617480 0.648 rs9864243 chr3:48982732 G/A cg07636037 chr3:49044803 WDR6 0.86 10.94 0.52 5.82e-24 Subjective well-being (multi-trait analysis);Menarche (age at onset); CRC cis rs11212617 0.967 rs7395528 chr11:108056708 A/C cg01991180 chr11:108092276 ATM;NPAT 0.43 6.29 0.33 1.02e-9 Response to metformin in type 2 diabetes (glycemic); CRC cis rs2522056 1.000 rs6874639 chr5:131778716 C/T cg24060327 chr5:131705240 SLC22A5 -0.42 -5.95 -0.31 7e-9 Lymphocyte counts;Fibrinogen; CRC cis rs13191362 1.000 rs67646369 chr6:163003233 T/C cg06582575 chr6:163149167 PACRG;PARK2 0.77 10.7 0.51 3.98e-23 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs875971 0.862 rs7796162 chr7:65745758 T/C cg11764359 chr7:65958608 NA -0.59 -8.7 -0.43 1.63e-16 Aortic root size; CRC cis rs5769765 0.913 rs4824111 chr22:50284305 A/G cg22709217 chr22:50311962 ALG12;CRELD2 1.03 16.54 0.67 3.73e-45 Schizophrenia; CRC trans rs11661542 0.967 rs11082043 chr18:20222985 C/G cg21092177 chr17:73128031 NT5C -0.43 -6.22 -0.32 1.55e-9 Intracranial aneurysm; CRC cis rs13108904 0.901 rs4493484 chr4:1279944 G/A cg19318889 chr4:1322082 MAEA 0.4 5.68 0.3 2.94e-8 Obesity-related traits; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg20488244 chr18:57026141 LMAN1 0.45 6.15 0.32 2.19e-9 Thyroid stimulating hormone; CRC cis rs2304069 0.733 rs216138 chr5:149437190 C/G cg22760475 chr5:149380129 HMGXB3;TIGD6 0.68 8.13 0.41 8.85e-15 HIV-1 control; CRC cis rs4660306 0.961 rs12082256 chr1:45951380 A/G cg03123370 chr1:45965343 CCDC163P;MMACHC -0.56 -7.85 -0.4 6.06e-14 Homocysteine levels; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg21515243 chr18:21033072 RIOK3 0.52 6.98 0.36 1.59e-11 Thyroid stimulating hormone; CRC cis rs17095355 0.901 rs17126938 chr10:111761351 T/C cg00817464 chr10:111662876 XPNPEP1 -0.5 -5.98 -0.31 5.84e-9 Biliary atresia; CRC cis rs3733585 0.683 rs13112015 chr4:9933796 C/T cg00071950 chr4:10020882 SLC2A9 -0.63 -11.28 -0.53 3.61e-25 Cleft plate (environmental tobacco smoke interaction); CRC trans rs1814175 0.619 rs847644 chr11:49918418 G/A cg03929089 chr4:120376271 NA -0.91 -16.07 -0.66 2.65e-43 Height; CRC cis rs11758351 1.000 rs16891405 chr6:26204506 A/G cg22723502 chr6:26240528 HIST1H4F -0.38 -6.08 -0.32 3.36e-9 Gout;Renal underexcretion gout; CRC trans rs2553218 0.690 rs8032415 chr15:54851945 A/G cg11388507 chr10:102027143 CWF19L1 0.48 6.39 0.33 5.74e-10 Immune response to smallpox vaccine (IL-6); CRC cis rs7618915 0.571 rs6805539 chr3:52609710 T/A cg18404041 chr3:52824283 ITIH1 -0.42 -8.79 -0.44 8.25e-17 Bipolar disorder; CRC cis rs7618915 0.508 rs12498066 chr3:52627660 G/A cg05573699 chr3:52720067 GNL3;PBRM1 -0.46 -6.62 -0.34 1.44e-10 Bipolar disorder; CRC cis rs4654899 0.758 rs6688147 chr1:21335894 A/G cg02927042 chr1:21476669 EIF4G3 -0.4 -6.34 -0.33 7.6e-10 Superior frontal gyrus grey matter volume; CRC cis rs28386778 1.000 rs2665851 chr17:61957023 T/C cg06601766 chr17:61851465 DDX42;CCDC47 0.45 6.14 0.32 2.39e-9 Prudent dietary pattern; CRC trans rs1997103 1.000 rs2331068 chr7:55408220 G/A cg20935933 chr6:143382018 AIG1 0.51 6.65 0.34 1.25e-10 QRS interval (sulfonylurea treatment interaction); CRC cis rs755249 0.567 rs41270811 chr1:39815344 G/A cg18385671 chr1:39797026 MACF1 -0.41 -5.77 -0.3 1.81e-8 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs758324 0.947 rs4705900 chr5:131140241 G/A cg06307176 chr5:131281290 NA 0.45 6.53 0.34 2.55e-10 Alzheimer's disease in APOE e4- carriers; CRC cis rs763014 0.966 rs4984675 chr16:670117 T/C cg18653534 chr16:772142 FAM173A -0.39 -6.11 -0.32 2.8e-9 Height; CRC trans rs1005277 0.522 rs289650 chr10:37975505 G/T cg17830980 chr10:43048298 ZNF37B -0.4 -6.43 -0.33 4.55e-10 Extrinsic epigenetic age acceleration; CRC trans rs4746003 0.752 rs9919438 chr10:71533042 G/A cg10166889 chr5:61028374 NA 0.4 6.12 0.32 2.63e-9 Psychosis and Alzheimer's disease; CRC cis rs4665809 1.000 rs1030730 chr2:26284143 T/C cg22920501 chr2:26401640 FAM59B -0.57 -7.37 -0.38 1.42e-12 Gut microbiome composition (summer); CRC cis rs11148252 0.811 rs9536030 chr13:52938291 G/A cg02158880 chr13:53174818 NA -0.43 -6.54 -0.34 2.29e-10 Lewy body disease; CRC cis rs10504229 1.000 rs61998259 chr8:58192290 T/C cg02290350 chr8:58132656 NA -0.42 -5.96 -0.31 6.62e-9 Developmental language disorder (linguistic errors); CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg03901462 chr11:62572874 NXF1 0.38 6.17 0.32 1.96e-9 Obesity-related traits; CRC cis rs3820068 0.705 rs57440988 chr1:15879034 T/C cg27534772 chr1:16042836 PLEKHM2 0.45 7.5 0.38 6.07e-13 Systolic blood pressure; CRC trans rs7618501 0.735 rs9876508 chr3:49780844 G/A cg21582582 chr3:182698605 DCUN1D1 -0.56 -8.34 -0.42 2.08e-15 Intelligence (multi-trait analysis); CRC cis rs13064411 0.696 rs1552432 chr3:113225660 G/C cg10517650 chr3:113235015 CCDC52 -0.41 -7.29 -0.37 2.4e-12 Response to simvastatin treatment (PCSK9 protein level change); CRC cis rs62458065 0.850 rs7785999 chr7:32461262 G/T cg20159608 chr7:32802032 NA -0.56 -6.94 -0.36 2.05e-11 Metabolite levels (HVA/MHPG ratio); CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg20541753 chr11:34938014 PDHX;APIP 0.45 6.38 0.33 6e-10 Anxiety disorder; CRC cis rs72781680 1.000 rs11553491 chr2:24225901 G/C cg08917208 chr2:24149416 ATAD2B 0.89 8.73 0.43 1.32e-16 Lymphocyte counts; CRC cis rs2739330 0.731 rs2000468 chr22:24241611 G/T cg18538332 chr22:24372958 LOC391322 -0.67 -10.53 -0.5 1.55e-22 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs9783347 1.000 rs1140047 chr11:18327684 G/T cg15585147 chr11:18324498 HPS5 0.42 5.9 0.31 8.87e-9 Pancreatic cancer; CRC cis rs7412746 0.658 rs4970982 chr1:150865084 G/C cg17724175 chr1:150552817 MCL1 0.44 6.55 0.34 2.27e-10 Melanoma; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg23330034 chr19:41770021 HNRNPUL1 0.52 6.77 0.35 5.83e-11 Thyroid stimulating hormone; CRC cis rs736801 0.569 rs12517950 chr5:131731326 A/G cg02033258 chr5:131593261 PDLIM4 0.35 6.16 0.32 2.12e-9 Breast cancer;Mosquito bite size; CRC cis rs1538970 0.962 rs9429075 chr1:45818421 G/A cg05343316 chr1:45956843 TESK2 0.69 9.24 0.45 3.22e-18 Platelet count; CRC cis rs7772486 0.875 rs2207785 chr6:146332784 T/G cg23711669 chr6:146136114 FBXO30 0.62 10.44 0.5 3.03e-22 Lobe attachment (rater-scored or self-reported); CRC cis rs4975709 0.589 rs1466606 chr5:1865055 C/T cg11168104 chr5:1857477 NA -0.39 -6.72 -0.35 7.83e-11 Cardiovascular disease risk factors; CRC cis rs17092148 1.000 rs6060025 chr20:33326876 A/G cg08999081 chr20:33150536 PIGU 0.46 5.68 0.3 2.99e-8 Neuroticism; CRC cis rs2898681 0.614 rs11947787 chr4:53705225 C/A cg00338735 chr4:53728038 RASL11B 0.42 6.3 0.33 9.57e-10 Optic nerve measurement (cup area); CRC cis rs896854 0.902 rs896852 chr8:95960886 G/T cg16049864 chr8:95962084 TP53INP1 -0.67 -12.39 -0.56 3.32e-29 Type 2 diabetes; CRC cis rs3087591 1.000 rs2854322 chr17:29699416 C/T cg24425628 chr17:29625626 OMG;NF1 0.87 16.39 0.67 1.5e-44 Hip circumference; CRC cis rs10504229 0.683 rs16921819 chr8:58107936 G/T cg04204079 chr8:58130323 NA -0.46 -5.79 -0.3 1.67e-8 Developmental language disorder (linguistic errors); CRC trans rs1814175 0.817 rs7932683 chr11:49983640 G/A cg03929089 chr4:120376271 NA -0.98 -19.36 -0.73 2.81e-56 Height; CRC cis rs711830 1.000 rs1318778 chr2:177037831 C/G cg13092806 chr2:177043255 NA 0.72 8.93 0.44 3.01e-17 Serous invasive ovarian cancer;Epithelial ovarian cancer;Invasive epithelial ovarian cancer;Mucinous ovarian carcinoma;Low-grade serous and serous borderline ovarian cancer;Serous borderline ovarian cancer;High-grade serous ovarian cancer; CRC trans rs9929218 0.551 rs2274240 chr16:68725486 A/G cg04657470 chr2:198365150 HSPE1;HSPD1 1.18 29.14 0.85 3.73e-93 Colorectal cancer; CRC cis rs3785574 0.638 rs2854182 chr17:61969062 G/A cg06601766 chr17:61851465 DDX42;CCDC47 0.61 8.46 0.42 8.91e-16 Height; CRC cis rs2033711 0.837 rs3764535 chr19:58929052 G/A cg13877915 chr19:58951672 ZNF132 0.46 7.35 0.38 1.62e-12 Uric acid clearance; CRC cis rs6163 0.508 rs12776506 chr10:104532828 A/G cg04362960 chr10:104952993 NT5C2 0.55 6.48 0.34 3.34e-10 Waist circumference;Hip circumference; CRC cis rs7666738 0.716 rs6827474 chr4:99089683 T/G cg17366294 chr4:99064904 C4orf37 0.35 5.66 0.3 3.38e-8 Colonoscopy-negative controls vs population controls; CRC cis rs3126085 0.515 rs10788837 chr1:152351487 A/G cg09127314 chr1:152161683 NA -0.44 -5.73 -0.3 2.23e-8 Atopic dermatitis; CRC trans rs1656966 1.000 rs1656966 chr3:186466252 C/T cg13645767 chr9:97766849 C9orf3 0.42 6.24 0.33 1.36e-9 Myopia (pathological); CRC cis rs9443645 0.869 rs9343863 chr6:79752792 T/C cg05283184 chr6:79620031 NA -0.63 -10.0 -0.48 9.88e-21 Intelligence (multi-trait analysis); CRC cis rs34779708 0.931 rs34815241 chr10:35296676 T/C cg03585969 chr10:35415529 CREM 0.65 8.78 0.44 9.01e-17 Inflammatory bowel disease;Crohn's disease; CRC cis rs4252707 1 rs4252707 chr1:204508147 G/A cg17419461 chr1:204415978 PIK3C2B -0.57 -8.01 -0.4 2.07e-14 Glioma;Non-glioblastoma glioma; CRC cis rs9291683 0.527 rs11727087 chr4:10096020 A/G cg00071950 chr4:10020882 SLC2A9 0.56 9.49 0.46 4.91e-19 Bone mineral density; CRC cis rs870825 0.616 rs28558715 chr4:185627761 G/A cg04058563 chr4:185651563 MLF1IP 0.72 9.38 0.46 1.12e-18 Blood protein levels; CRC cis rs2075371 0.966 rs722657 chr7:133994956 T/C cg11752832 chr7:134001865 SLC35B4 0.49 7.59 0.39 3.36e-13 Mean platelet volume; CRC cis rs3996993 0.809 rs62412906 chr6:52736685 T/C cg20803780 chr6:52668592 GSTA1 0.37 6.84 0.35 3.84e-11 Hemoglobin concentration; CRC cis rs2070677 0.935 rs4582924 chr10:135409033 T/G cg20169779 chr10:135381914 SYCE1 -1.0 -15.67 -0.65 9.85e-42 Gout; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg03489495 chr6:33588875 ITPR3 0.45 6.29 0.33 9.86e-10 Response to antipsychotic treatment; CRC cis rs1179624 0.679 rs4731235 chr7:75265277 C/G cg05145297 chr7:75264568 HIP1 0.6 8.2 0.41 5.44e-15 Age-related nuclear cataracts; CRC cis rs12681287 0.888 rs2976201 chr8:87335937 T/C cg27223183 chr8:87520930 FAM82B -0.46 -6.34 -0.33 7.46e-10 Caudate activity during reward; CRC cis rs9399137 0.507 rs4580893 chr6:135297662 G/A cg24558204 chr6:135376177 HBS1L 0.61 9.23 0.45 3.43e-18 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; CRC cis rs1691799 0.899 rs1185244 chr12:66725160 C/T cg16791601 chr12:66731901 HELB -0.68 -11.51 -0.54 5.35e-26 White blood cell count (basophil); CRC cis rs6089584 0.566 rs7274240 chr20:60622004 C/T cg13770153 chr20:60521292 NA -0.42 -6.41 -0.33 5.13e-10 Body mass index; CRC cis rs4819052 0.851 rs2838857 chr21:46681000 A/G cg02159808 chr21:46707872 POFUT2;LOC642852 0.51 6.76 0.35 6.41e-11 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs7772486 0.754 rs1415747 chr6:146077249 A/G cg13319975 chr6:146136371 FBXO30 -0.49 -7.33 -0.37 1.83e-12 Lobe attachment (rater-scored or self-reported); CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg00157456 chr16:72042372 DHODH 0.45 6.04 0.32 4.27e-9 Anxiety disorder; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg25148255 chr8:17941568 ASAH1 0.45 6.0 0.31 5.19e-9 Anxiety disorder; CRC cis rs6496044 0.611 rs8026938 chr15:86069118 G/T cg17133734 chr15:86042851 AKAP13 -0.38 -6.17 -0.32 2e-9 Interstitial lung disease; CRC cis rs853679 0.517 rs3757187 chr6:28107654 T/C cg25164649 chr6:28176230 NA 0.76 9.53 0.46 3.71e-19 Depression; CRC cis rs7584330 0.704 rs7598954 chr2:238364776 C/T cg16989719 chr2:238392110 NA -0.4 -6.69 -0.35 9.83e-11 Prostate cancer; CRC cis rs4970988 0.556 rs6681426 chr1:150586971 G/A cg17724175 chr1:150552817 MCL1 -0.69 -11.14 -0.52 1.16e-24 Urate levels; CRC cis rs3749237 0.595 rs17595772 chr3:49409704 G/A cg02487422 chr3:49467188 NICN1 0.42 6.89 0.35 2.9100000000000002e-11 Resting heart rate; CRC cis rs11971779 0.793 rs9632774 chr7:139137562 C/T cg07862535 chr7:139043722 LUC7L2 0.8 9.37 0.46 1.17e-18 Diisocyanate-induced asthma; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg01420088 chr10:101491661 CUTC;COX15 0.54 7.6 0.39 3.16e-13 Response to antipsychotic treatment; CRC cis rs28386778 1.000 rs2665849 chr17:61953670 T/C cg06601766 chr17:61851465 DDX42;CCDC47 0.45 6.21 0.32 1.61e-9 Prudent dietary pattern; CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg13360871 chr11:64013991 PPP1R14B 0.4 6.04 0.32 4.19e-9 Obesity-related traits; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg15260365 chr11:67771606 UNC93B1 0.4 6.62 0.34 1.47e-10 Liver disease severity in Alagille syndrome; CRC cis rs7949030 0.626 rs11231141 chr11:62326265 T/C cg11742103 chr11:62369870 EML3;MTA2 0.62 11.92 0.55 1.86e-27 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; CRC cis rs7193541 0.662 rs8063458 chr16:74469121 G/T cg01733217 chr16:74700730 RFWD3 -0.73 -12.51 -0.57 1.24e-29 Multiple myeloma; CRC cis rs9911578 0.765 rs66954617 chr17:56999427 A/G cg05425664 chr17:57184151 TRIM37 -0.49 -7.8 -0.39 8.34e-14 Intelligence (multi-trait analysis); CRC cis rs11758351 1.000 rs2143346 chr6:26198449 C/G cg22723502 chr6:26240528 HIST1H4F 0.37 5.65 0.3 3.46e-8 Gout;Renal underexcretion gout; CRC cis rs3784262 1.000 rs1372368 chr15:58297363 C/T cg12031962 chr15:58353849 ALDH1A2 -0.34 -5.93 -0.31 7.53e-9 Barrett's esophagus;Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined); CRC cis rs9354308 0.933 rs2814134 chr6:66566658 C/G cg07460842 chr6:66804631 NA 0.47 5.92 0.31 8.03e-9 Metabolite levels; CRC cis rs1552244 1.000 rs12152512 chr3:10143770 C/T cg08888203 chr3:10149979 C3orf24 0.68 9.81 0.48 4.35e-20 Alzheimer's disease; CRC trans rs1864729 1.000 rs2451113 chr8:98273448 G/A cg08679828 chr8:102218111 ZNF706 -0.58 -6.99 -0.36 1.56e-11 Estradiol plasma levels (breast cancer); CRC cis rs2739330 0.796 rs1006771 chr22:24314006 G/T cg18538332 chr22:24372958 LOC391322 -0.71 -11.39 -0.53 1.51e-25 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs1448094 0.533 rs7955135 chr12:86146350 G/A cg02569458 chr12:86230093 RASSF9 -0.48 -8.08 -0.41 1.27e-14 Major depressive disorder; CRC cis rs34864796 0.547 rs200476 chr6:27768348 A/T cg06470822 chr6:28175283 NA 0.59 6.9 0.36 2.62e-11 Lung function (FEV1);Lung function (FEV1/FVC);Lung function (FVC); CRC cis rs1448094 0.511 rs58742237 chr12:86166444 C/T cg18827107 chr12:86230957 RASSF9 -0.39 -6.01 -0.31 4.81e-9 Major depressive disorder; CRC trans rs11098499 0.691 rs12510133 chr4:120271344 A/C cg25214090 chr10:38739885 LOC399744 0.53 8.51 0.42 6.28e-16 Corneal astigmatism; CRC cis rs1552244 1.000 rs35741213 chr3:10087661 A/G cg08888203 chr3:10149979 C3orf24 0.73 10.16 0.49 2.86e-21 Alzheimer's disease; CRC cis rs11764590 0.694 rs7801349 chr7:2085553 T/C cg14004847 chr7:1930337 MAD1L1 -0.43 -5.78 -0.3 1.73e-8 Neuroticism; CRC cis rs755249 0.567 rs66727439 chr1:39711930 C/T cg18385671 chr1:39797026 MACF1 -0.44 -6.09 -0.32 3.08e-9 Peripheral arterial disease (traffic-related air pollution interaction); CRC trans rs875971 0.545 rs801199 chr7:66025273 A/G cg02869306 chr7:64672164 INTS4L1 0.44 6.39 0.33 5.74e-10 Aortic root size; CRC cis rs2070488 0.699 rs13064938 chr3:38440237 T/C cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.73 12.73 0.57 1.89e-30 Electrocardiographic conduction measures; CRC trans rs7267979 1.000 rs7018 chr20:25278261 A/G cg17903999 chr18:56338584 MALT1 -0.41 -6.77 -0.35 5.83e-11 Liver enzyme levels (alkaline phosphatase); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg23300289 chr9:132146083 NA 0.44 6.26 0.33 1.18e-9 Response to antipsychotic treatment; CRC cis rs6076065 0.723 rs2275788 chr20:23338694 G/A cg11657817 chr20:23433608 CST11 0.46 6.77 0.35 5.86e-11 Facial morphology (factor 15, philtrum width); CRC cis rs13191362 0.810 rs13200053 chr6:163011443 G/A cg23758597 chr6:163146217 PARK2 -0.55 -6.12 -0.32 2.7e-9 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs9325144 0.647 rs12822023 chr12:39097964 T/C cg26384229 chr12:38710491 ALG10B -0.52 -7.34 -0.37 1.74e-12 Morning vs. evening chronotype; CRC cis rs7517126 1.000 rs12240148 chr1:196845307 T/C cg13682187 chr1:196946512 CFHR5 -0.38 -5.89 -0.31 9.4e-9 Blood protein levels; CRC cis rs2836974 0.932 rs8128734 chr21:40569511 G/A cg06238570 chr21:40685208 BRWD1 0.78 10.7 0.51 3.88e-23 Cognitive function; CRC trans rs66759488 0.739 rs10851451 chr15:47608991 A/G cg08942682 chr3:197409980 KIAA0226 -0.46 -6.35 -0.33 7.06e-10 Lung cancer; CRC cis rs12142240 0.698 rs10158130 chr1:46822600 T/C cg00530320 chr1:46809349 NSUN4 0.59 8.03 0.41 1.69e-14 Menopause (age at onset); CRC cis rs6701037 1.000 rs6681020 chr1:175125264 G/A cg00321850 chr1:175162397 KIAA0040 -0.36 -5.9 -0.31 8.95e-9 Alcohol dependence; CRC cis rs910316 0.737 rs28687415 chr14:75495482 T/C cg03030879 chr14:75389066 RPS6KL1 -0.4 -6.2 -0.32 1.68e-9 Height; CRC trans rs66887589 0.774 rs9307477 chr4:120421809 G/A cg25214090 chr10:38739885 LOC399744 0.41 6.3 0.33 9.7e-10 Diastolic blood pressure; CRC cis rs6500602 0.673 rs4786512 chr16:4573040 A/G cg13763550 chr16:4524223 NMRAL1;HMOX2 0.45 5.83 0.31 1.33e-8 Schizophrenia; CRC cis rs9487051 0.714 rs6927569 chr6:109621494 T/C cg21918786 chr6:109611834 NA -0.41 -7.14 -0.37 6.13e-12 Reticulocyte fraction of red cells; CRC cis rs116095464 0.558 rs6869925 chr5:264036 A/G cg22496380 chr5:211416 CCDC127 -0.91 -10.46 -0.5 2.65e-22 Breast cancer; CRC cis rs6701037 0.875 rs6929 chr1:175126721 A/G cg14847009 chr1:175162515 KIAA0040 -0.28 -5.99 -0.31 5.56e-9 Alcohol dependence; CRC cis rs7923609 0.841 rs10822186 chr10:65350383 A/G cg08743896 chr10:65200160 JMJD1C -0.41 -5.73 -0.3 2.22e-8 Educational attainment;Liver enzyme levels (alkaline phosphatase); CRC cis rs6732160 0.613 rs57208378 chr2:73389999 G/A cg01422370 chr2:73384389 NA 0.37 5.63 0.3 3.86e-8 Intelligence (multi-trait analysis); CRC cis rs62432291 0.681 rs386818 chr6:159660255 T/C cg14500486 chr6:159655392 FNDC1 -0.76 -10.24 -0.49 1.49e-21 Joint mobility (Beighton score); CRC cis rs473651 0.935 rs477041 chr2:239355995 C/G cg08773314 chr2:239334832 ASB1 -0.37 -8.66 -0.43 2.21e-16 Multiple system atrophy; CRC cis rs727505 1.000 rs722560 chr7:124488035 T/C cg23710748 chr7:124431027 NA -0.83 -14.63 -0.63 1.07e-37 Lewy body disease; CRC cis rs8177253 0.665 rs11921527 chr3:133441167 G/A cg24879335 chr3:133465180 TF 0.37 6.92 0.36 2.36e-11 Iron status biomarkers; CRC cis rs951366 0.764 rs823141 chr1:205741426 T/C cg14159672 chr1:205819179 PM20D1 0.74 10.97 0.52 4.67e-24 Menarche (age at onset); CRC cis rs2404602 0.716 rs12592171 chr15:76755133 G/C cg03037974 chr15:76606532 NA 0.73 13.13 0.59 5.83e-32 Blood metabolite levels; CRC cis rs875971 1.000 rs1981798 chr7:65954903 G/T cg11764359 chr7:65958608 NA 0.64 10.22 0.49 1.76e-21 Aortic root size; CRC cis rs7762018 0.556 rs80250989 chr6:170105553 T/C cg24289452 chr6:170231220 NA -0.83 -7.15 -0.37 5.53e-12 Thiazide-induced adverse metabolic effects in hypertensive patients; CRC cis rs7618915 0.508 rs13065851 chr3:52644836 T/A cg07507251 chr3:52567010 NT5DC2 0.46 6.64 0.34 1.3e-10 Bipolar disorder; CRC cis rs4731207 0.698 rs4552839 chr7:124499514 T/C cg23710748 chr7:124431027 NA -0.38 -6.14 -0.32 2.36e-9 Cutaneous malignant melanoma; CRC trans rs9914544 0.628 rs4924924 chr17:18677774 C/G cg04702396 chr17:15466718 FAM18B2 0.57 9.2 0.45 4.27e-18 Educational attainment (years of education); CRC cis rs10791323 0.633 rs2171006 chr11:133728323 T/C cg15485101 chr11:133734466 NA 0.47 8.58 0.43 3.91e-16 Childhood ear infection; CRC cis rs2717559 0.542 rs10956986 chr8:143886601 C/T cg24046110 chr8:143859143 LYNX1 -0.76 -14.45 -0.62 5.36e-37 Urinary tract infection frequency; CRC cis rs9443645 0.901 rs7742431 chr6:79679577 A/G cg09184832 chr6:79620586 NA -0.47 -8.55 -0.43 4.81e-16 Intelligence (multi-trait analysis); CRC cis rs7772486 0.701 rs11155438 chr6:145950112 C/G cg23711669 chr6:146136114 FBXO30 0.74 12.65 0.57 3.54e-30 Lobe attachment (rater-scored or self-reported); CRC cis rs1707322 1.000 rs7531911 chr1:46330423 A/G cg03146154 chr1:46216737 IPP 0.5 6.96 0.36 1.83e-11 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs7089973 1.000 rs7089973 chr10:116569565 A/C cg23260525 chr10:116636907 FAM160B1 -0.33 -7.23 -0.37 3.43e-12 Bipolar disorder or attention deficit hyperactivity disorder; CRC cis rs8177253 0.665 rs9869535 chr3:133451581 G/A cg17775713 chr3:133465469 TF 0.33 5.85 0.31 1.19e-8 Iron status biomarkers; CRC cis rs12597458 0.752 rs8051239 chr16:72036257 T/A cg01557791 chr16:72042693 DHODH 0.64 10.08 0.49 5.26e-21 Prostate cancer; CRC cis rs9915657 0.870 rs11077595 chr17:70130030 C/T cg09344028 chr17:70110421 NA 0.44 6.65 0.34 1.2e-10 Thyroid hormone levels; CRC cis rs889312 0.521 rs12651942 chr5:56088484 C/T cg18230493 chr5:56204884 C5orf35 -0.42 -6.38 -0.33 6.14e-10 Breast cancer;Breast cancer (early onset); CRC cis rs951366 0.789 rs864783 chr1:205711974 T/C cg14159672 chr1:205819179 PM20D1 0.72 10.49 0.5 2.11e-22 Menarche (age at onset); CRC cis rs11148252 0.774 rs56033750 chr13:52747278 A/C cg00495681 chr13:53174319 NA 0.62 9.82 0.48 3.99e-20 Lewy body disease; CRC cis rs2075371 1.000 rs2544213 chr7:133982867 G/C cg11752832 chr7:134001865 SLC35B4 0.48 7.49 0.38 6.33e-13 Mean platelet volume; CRC cis rs914615 0.508 rs4971079 chr1:155130391 C/T cg02153340 chr1:155202674 NA -0.39 -5.63 -0.3 3.85e-8 Urinary albumin-to-creatinine ratio; CRC cis rs644799 0.965 rs11021310 chr11:95502106 A/C cg25478527 chr11:95522999 CEP57;FAM76B 0.52 7.65 0.39 2.31e-13 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs9733 0.536 rs6661415 chr1:150635869 G/A cg17724175 chr1:150552817 MCL1 0.59 9.47 0.46 5.5e-19 Tonsillectomy; CRC cis rs6496044 0.547 rs8039929 chr15:86080962 C/T cg17133734 chr15:86042851 AKAP13 0.42 6.78 0.35 5.75e-11 Interstitial lung disease; CRC cis rs9826463 0.757 rs66597875 chr3:142264782 T/C cg20824294 chr3:142316082 PLS1 0.4 6.79 0.35 5.33e-11 QRS duration in Tripanosoma cruzi seropositivity; CRC cis rs11785400 0.963 rs4579507 chr8:143733663 C/G cg10596483 chr8:143751796 JRK 0.49 7.0 0.36 1.46e-11 Schizophrenia; CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg03578541 chr16:72128063 TXNL4B;DHX38 -0.58 -7.04 -0.36 1.13e-11 Diisocyanate-induced asthma; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg01027365 chr2:191184571 HIBCH 0.4 6.18 0.32 1.92e-9 Liver disease severity in Alagille syndrome; CRC trans rs10506458 0.834 rs73125186 chr12:63373400 C/T cg03429785 chr15:59498649 MYO1E;LDHAL6B -1.46 -20.67 -0.75 2.07e-61 Hemostatic factors and hematological phenotypes; CRC cis rs7586879 0.828 rs9631062 chr2:25110084 C/T cg22495460 chr2:25135724 ADCY3 -0.88 -15.19 -0.64 7.37e-40 Body mass index; CRC cis rs929354 1.000 rs1182384 chr7:157040642 A/G cg05182265 chr7:156933206 UBE3C 0.73 13.96 0.61 4.04e-35 Body mass index; CRC cis rs9303542 0.625 rs62065846 chr17:46592858 G/A cg04904318 chr17:46607828 HOXB1 -0.54 -6.41 -0.33 4.95e-10 Ovarian cancer;Epithelial ovarian cancer; CRC cis rs992157 0.835 rs12987219 chr2:219144149 G/A cg04731861 chr2:219085781 ARPC2 0.33 6.94 0.36 2.14e-11 Colorectal cancer; CRC trans rs16846053 0.579 rs57887363 chr2:162588720 C/T cg09481857 chr22:21368659 P2RX6;MGC16703 -0.64 -6.1 -0.32 3.04e-9 Blood osmolality (transformed sodium); CRC cis rs4481887 0.676 rs1538704 chr1:248523554 C/T cg00666640 chr1:248458726 OR2T12 0.34 6.4 0.33 5.42e-10 Common traits (Other); CRC cis rs4665809 0.590 rs35746418 chr2:26455002 C/G cg26119090 chr2:26468346 HADHA;HADHB 1.06 15.5 0.65 4.69e-41 Gut microbiome composition (summer); CRC cis rs7705042 0.793 rs10463348 chr5:141502035 G/T cg07392085 chr5:141489673 NDFIP1 0.47 7.42 0.38 1.03e-12 Asthma; CRC trans rs12200782 0.649 rs7775720 chr6:26381357 A/C cg25800765 chr12:85673347 ALX1 0.26 5.98 0.31 5.95e-9 Small cell lung carcinoma; CRC cis rs7131987 0.621 rs57803026 chr12:29497506 G/A cg09582351 chr12:29534625 ERGIC2 -0.35 -7.39 -0.38 1.24e-12 QT interval; CRC cis rs7666738 0.830 rs13138059 chr4:99050430 A/G cg05340658 chr4:99064831 C4orf37 0.6 9.24 0.45 3.19e-18 Colonoscopy-negative controls vs population controls; CRC cis rs4601821 1.000 rs877138 chr11:113256508 A/G cg14159747 chr11:113255604 NA -0.52 -9.85 -0.48 3.14e-20 Alcoholic chronic pancreatitis; CRC cis rs896854 1.000 rs7003387 chr8:95961979 C/G cg23172400 chr8:95962367 TP53INP1 -0.48 -7.96 -0.4 2.88e-14 Type 2 diabetes; CRC cis rs10504229 0.683 rs949856 chr8:58144496 G/A cg04204079 chr8:58130323 NA -0.45 -5.84 -0.31 1.28e-8 Developmental language disorder (linguistic errors); CRC cis rs6496667 0.779 rs62020734 chr15:90998430 G/C cg04176472 chr15:90893244 GABARAPL3 0.59 8.29 0.42 2.95e-15 Rheumatoid arthritis; CRC cis rs2243480 1.000 rs10950032 chr7:65738591 C/A cg18252515 chr7:66147081 NA 1.27 14.66 0.63 8.59e-38 Diabetic kidney disease; CRC cis rs4253772 0.550 rs6008600 chr22:46704676 A/G cg24881330 chr22:46731750 TRMU 0.63 7.15 0.37 5.73e-12 LDL cholesterol;Cholesterol, total; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg02466711 chr8:102218365 ZNF706 0.44 6.21 0.32 1.57e-9 Anxiety disorder; CRC cis rs7220401 0.512 rs2289629 chr17:27959903 A/G cg26525008 chr17:28256777 EFCAB5;SSH2 0.6 8.47 0.42 8.11e-16 Coronary artery disease; CRC cis rs6700896 0.931 rs11208715 chr1:66154414 G/T cg04111102 chr1:66153794 NA 0.35 6.07 0.32 3.47e-9 C-reactive protein;Mean corpuscular volume;Mean corpuscular hemoglobin; CRC cis rs2204008 0.837 rs11495722 chr12:38337245 G/A cg26384229 chr12:38710491 ALG10B 0.68 9.15 0.45 6.16e-18 Bladder cancer; CRC cis rs6543140 0.964 rs2310301 chr2:103072935 C/T cg04239558 chr2:103089729 SLC9A4 0.37 6.58 0.34 1.83e-10 Blood protein levels; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg00489730 chr2:29118113 WDR43 0.44 6.16 0.32 2.08e-9 Response to antipsychotic treatment; CRC trans rs7615952 0.741 rs13314845 chr3:125644782 C/T cg21747405 chr11:67723411 NA -0.44 -6.26 -0.33 1.23e-9 Blood pressure (smoking interaction); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg08299045 chr1:228296964 MRPL55 0.43 6.04 0.32 4.25e-9 Response to antipsychotic treatment; CRC cis rs10504229 0.953 rs116564484 chr8:58172818 T/C cg01721255 chr8:58191610 C8orf71 0.47 6.02 0.31 4.74e-9 Developmental language disorder (linguistic errors); CRC cis rs13191362 1.000 rs73035021 chr6:163000716 C/A cg21926612 chr6:163149169 PACRG;PARK2 0.8 11.25 0.53 4.59e-25 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg21440829 chr7:100808893 VGF 0.48 6.58 0.34 1.91e-10 Anxiety disorder; CRC trans rs10155879 0.505 rs12704265 chr7:86142678 A/G cg22078572 chr18:61033618 KDSR 0.55 6.13 0.32 2.48e-9 Interleukin-4 levels; CRC cis rs2084637 1.000 rs10892855 chr11:122396173 C/A cg21585512 chr11:122030076 LOC399959 -0.41 -7.49 -0.38 6.44e-13 Stroke; CRC cis rs7647973 0.710 rs9869120 chr3:49624065 T/C cg03060546 chr3:49711283 APEH 0.66 7.37 0.38 1.41e-12 Menarche (age at onset); CRC cis rs6952808 0.929 rs2280546 chr7:1976863 G/A cg22963979 chr7:1858916 MAD1L1 -0.54 -7.66 -0.39 2.11e-13 Bipolar disorder and schizophrenia; CRC cis rs896854 0.715 rs12548874 chr8:95935164 A/C cg16049864 chr8:95962084 TP53INP1 0.63 11.0 0.52 3.49e-24 Type 2 diabetes; CRC cis rs7953508 0.506 rs3869308 chr12:93959918 A/G cg18151635 chr12:93972918 NA -0.79 -11.7 -0.54 1.13e-26 Pubertal anthropometrics; CRC cis rs13144136 0.687 rs4235336 chr4:10663850 C/T cg10242279 chr4:10666415 CLNK -0.39 -6.59 -0.34 1.78e-10 Resistance to antihypertensive treatment in hypertension; CRC cis rs2075371 1.000 rs2241334 chr7:133979225 C/G cg11752832 chr7:134001865 SLC35B4 0.49 7.44 0.38 8.82e-13 Mean platelet volume; CRC cis rs4713118 0.513 rs149954 chr6:28035246 G/A cg23161317 chr6:28129485 ZNF389 0.45 6.46 0.34 3.87e-10 Parkinson's disease; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg05989775 chr11:2906934 CDKN1C 0.41 6.51 0.34 2.83e-10 Liver disease severity in Alagille syndrome; CRC cis rs12142240 0.698 rs1135459 chr1:46815930 C/T cg00530320 chr1:46809349 NSUN4 0.57 7.75 0.39 1.19e-13 Menopause (age at onset); CRC cis rs1799949 1.000 rs2292595 chr17:41290674 G/C cg05368731 chr17:41323189 NBR1 0.7 10.6 0.5 8.8e-23 Menopause (age at onset); CRC cis rs7020830 0.898 rs506981 chr9:37351348 A/T cg14294708 chr9:37120828 ZCCHC7 -1.01 -19.29 -0.73 5.44e-56 Schizophrenia; CRC cis rs9733 0.519 rs3768005 chr1:150680988 A/T cg15448220 chr1:150897856 SETDB1 0.49 7.02 0.36 1.24e-11 Tonsillectomy; CRC cis rs116095464 0.558 rs10080225 chr5:232175 A/G cg22857025 chr5:266934 NA -1.22 -16.68 -0.68 1.07e-45 Breast cancer; CRC cis rs727505 1.000 rs10244817 chr7:124467470 T/C cg23710748 chr7:124431027 NA -0.8 -14.25 -0.62 3.27e-36 Lewy body disease; CRC cis rs9368481 0.594 rs2636425 chr6:26799460 A/G cg18867708 chr6:26865862 GUSBL1 0.41 6.15 0.32 2.31e-9 Autism spectrum disorder or schizophrenia; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg04764131 chr4:16228633 TAPT1;FLJ39653 0.39 5.99 0.31 5.65e-9 Liver disease severity in Alagille syndrome; CRC cis rs2580764 0.565 rs6545466 chr2:55228392 C/T cg09592903 chr2:55203963 RTN4 -0.74 -11.92 -0.55 1.81e-27 Mean platelet volume; CRC cis rs7474896 0.583 rs34185758 chr10:37990854 T/C cg25427524 chr10:38739819 LOC399744 -0.58 -7.03 -0.36 1.18e-11 Obesity (extreme); CRC cis rs1005277 0.505 rs7917943 chr10:38195811 T/A cg25427524 chr10:38739819 LOC399744 0.74 13.04 0.58 1.23e-31 Extrinsic epigenetic age acceleration; CRC cis rs281302 0.621 rs281243 chr15:47737043 C/T cg13159054 chr15:47721715 NA 0.44 6.51 0.34 2.81e-10 Educational attainment (years of education);Cognitive ability (multi-trait analysis); CRC cis rs10504229 0.775 rs17805026 chr8:58160637 A/C cg11062466 chr8:58055876 NA 0.45 6.01 0.31 4.87e-9 Developmental language disorder (linguistic errors); CRC cis rs9325144 0.647 rs61930266 chr12:38922048 A/G cg26384229 chr12:38710491 ALG10B -0.52 -7.48 -0.38 6.84e-13 Morning vs. evening chronotype; CRC trans rs11098499 0.687 rs71610270 chr4:120287436 A/G cg25214090 chr10:38739885 LOC399744 0.6 9.4 0.46 9.63e-19 Corneal astigmatism; CRC cis rs977987 0.872 rs1542864 chr16:75471378 G/A cg03315344 chr16:75512273 CHST6 0.54 9.32 0.46 1.8e-18 Dupuytren's disease; CRC cis rs10504229 0.728 rs72650852 chr8:58150463 G/A cg22535103 chr8:58192502 C8orf71 -0.74 -8.72 -0.43 1.37e-16 Developmental language disorder (linguistic errors); CRC cis rs853679 1.000 rs1679732 chr6:28221264 G/A cg03623178 chr6:28175578 NA -0.67 -6.82 -0.35 4.28e-11 Depression; CRC cis rs7632954 0.669 rs7647092 chr3:8528431 A/G cg03495237 chr3:8533978 NA 0.36 6.64 0.34 1.33e-10 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs4974559 0.895 rs28493051 chr4:1331030 A/C cg02980000 chr4:1222292 CTBP1 0.51 6.4 0.33 5.34e-10 Systolic blood pressure; CRC cis rs7811142 0.779 rs28680963 chr7:99905475 C/G cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.05 14.06 0.61 1.8e-35 Platelet count; CRC cis rs501120 0.584 rs7902040 chr10:44695308 A/G cg09554077 chr10:44749378 NA 0.69 8.09 0.41 1.15e-14 Coronary artery disease;Coronary heart disease; CRC cis rs1044826 0.642 rs9833307 chr3:139181370 G/A cg00490450 chr3:139108681 COPB2 0.45 6.65 0.34 1.19e-10 Obesity-related traits; CRC cis rs898097 0.841 rs9896263 chr17:80902741 A/G cg15664640 chr17:80829946 TBCD 0.64 10.58 0.5 1e-22 Breast cancer; CRC cis rs11809207 0.523 rs2783706 chr1:26504697 A/G cg24519413 chr1:26490540 NA 0.37 6.27 0.33 1.14e-9 Height; CRC cis rs4713118 0.911 rs2394000 chr6:27686991 A/G cg03623178 chr6:28175578 NA 0.64 8.51 0.42 6.36e-16 Parkinson's disease; CRC cis rs4555082 0.681 rs28588570 chr14:105709606 A/T cg06808227 chr14:105710500 BRF1 -0.64 -9.58 -0.47 2.38e-19 Mean platelet volume;Platelet distribution width; CRC cis rs4072980 0.527 rs11210825 chr1:38446986 G/A cg26398791 chr1:38455867 SF3A3 -0.44 -5.92 -0.31 7.94e-9 Coronary artery disease; CRC cis rs754466 0.606 rs55854323 chr10:79589904 C/T cg17075019 chr10:79541650 NA -0.97 -17.26 -0.69 5.61e-48 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs875971 1.000 rs4718343 chr7:65874288 T/G cg18876405 chr7:65276391 NA 0.52 9.04 0.45 1.37e-17 Aortic root size; CRC cis rs4665809 1.000 rs1470097 chr2:26312840 A/G cg22920501 chr2:26401640 FAM59B -0.52 -7.22 -0.37 3.61e-12 Gut microbiome composition (summer); CRC cis rs12908161 1.000 rs12908549 chr15:85322351 C/G cg11189052 chr15:85197271 WDR73 0.58 8.32 0.42 2.37e-15 Schizophrenia; CRC cis rs72945132 0.825 rs2277273 chr11:70223992 T/C cg00319359 chr11:70116639 PPFIA1 0.55 6.04 0.32 4.17e-9 Coronary artery disease; CRC cis rs7412746 0.658 rs12067685 chr1:150952917 T/C cg18016565 chr1:150552671 MCL1 0.44 6.08 0.32 3.42e-9 Melanoma; CRC cis rs881375 1.000 rs10117059 chr9:123653477 G/C cg09586646 chr9:123605570 PSMD5;LOC253039 0.53 7.22 0.37 3.69e-12 Rheumatoid arthritis; CRC cis rs9976767 0.608 rs9784208 chr21:43824986 A/G cg23042151 chr21:43824109 UBASH3A -0.43 -7.49 -0.38 6.43e-13 Type 1 diabetes; CRC cis rs17376456 0.569 rs6556839 chr5:93206292 T/C cg25358565 chr5:93447407 FAM172A -0.65 -7.56 -0.38 3.94e-13 Diabetic retinopathy; CRC cis rs6951245 0.706 rs28483034 chr7:1170171 C/A cg18402987 chr7:1209562 NA 0.67 7.75 0.39 1.18e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg00024790 chr16:22385412 CDR2 0.48 7.18 0.37 4.8e-12 Intelligence (multi-trait analysis); CRC cis rs245880 0.740 rs245890 chr7:29190720 T/C cg17163760 chr7:29186267 CPVL -0.39 -6.74 -0.35 7.06e-11 Warfarin maintenance dose; CRC cis rs9291683 0.509 rs10939671 chr4:10050815 T/C cg00071950 chr4:10020882 SLC2A9 0.64 11.64 0.54 1.91e-26 Bone mineral density; CRC cis rs7615952 0.599 rs1875683 chr3:125732481 C/G cg06494592 chr3:125709126 NA -0.55 -6.58 -0.34 1.88e-10 Blood pressure (smoking interaction); CRC cis rs2251381 0.778 rs2245021 chr21:30546841 C/T cg24692254 chr21:30365293 RNF160 0.75 12.3 0.56 7.01e-29 Selective IgA deficiency; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg16456337 chr5:112312164 DCP2 0.45 6.96 0.36 1.83e-11 Intelligence (multi-trait analysis); CRC cis rs7772486 0.875 rs7766463 chr6:146364453 A/G cg23711669 chr6:146136114 FBXO30 0.68 11.85 0.55 3.22e-27 Lobe attachment (rater-scored or self-reported); CRC cis rs10504229 1.000 rs66936919 chr8:58172868 C/G cg22535103 chr8:58192502 C8orf71 -0.79 -12.09 -0.55 4.31e-28 Developmental language disorder (linguistic errors); CRC cis rs7772486 0.727 rs10447449 chr6:146138707 A/G cg13319975 chr6:146136371 FBXO30 -0.43 -6.42 -0.33 4.74e-10 Lobe attachment (rater-scored or self-reported); CRC cis rs889398 0.651 rs1566455 chr16:69900164 G/T cg00738113 chr16:70207722 CLEC18C -0.37 -6.3 -0.33 9.79e-10 Body mass index; CRC cis rs965469 0.895 rs6051839 chr20:3391191 C/T cg25506879 chr20:3388711 C20orf194 0.38 6.0 0.31 5.22e-9 IFN-related cytopenia; CRC cis rs13108904 0.539 rs13141169 chr4:1340353 C/T cg20092199 chr4:1342459 KIAA1530 0.46 7.21 0.37 3.87e-12 Obesity-related traits; CRC trans rs12478296 0.901 rs58906257 chr2:243028248 T/C cg18288967 chr1:45987694 PRDX1 0.65 7.38 0.38 1.31e-12 Obesity-related traits; CRC cis rs7100689 0.784 rs4934139 chr10:82177023 C/A cg00277334 chr10:82204260 NA -0.45 -5.86 -0.31 1.09e-8 Post bronchodilator FEV1; CRC cis rs4819052 0.851 rs4819042 chr21:46660072 A/G cg19498844 chr21:46707878 POFUT2;LOC642852 0.77 10.99 0.52 3.97e-24 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg08026144 chr9:78505312 PCSK5 0.45 6.65 0.34 1.25e-10 Liver disease severity in Alagille syndrome; CRC cis rs28386778 1.000 rs2955241 chr17:61968113 G/C cg23090583 chr17:61904693 PSMC5;FTSJ3 0.99 17.24 0.69 6.62e-48 Prudent dietary pattern; CRC cis rs7618501 1.000 rs3749240 chr3:49750188 T/A cg24308560 chr3:49941425 MST1R 0.44 6.86 0.35 3.46e-11 Intelligence (multi-trait analysis); CRC cis rs514406 0.929 rs12145105 chr1:53340564 T/C cg25767906 chr1:53392781 SCP2 -0.49 -7.9 -0.4 4.29e-14 Monocyte count; CRC cis rs847577 0.575 rs41278842 chr7:97815999 A/G cg24562669 chr7:97807699 LMTK2 -0.63 -11.56 -0.54 3.56e-26 Breast cancer; CRC cis rs7618915 0.571 rs2251219 chr3:52584787 C/T cg18404041 chr3:52824283 ITIH1 0.42 8.41 0.42 1.31e-15 Bipolar disorder; CRC cis rs6088580 0.634 rs6059779 chr20:32950325 C/T cg24642439 chr20:33292090 TP53INP2 -0.41 -6.8 -0.35 4.86e-11 Glomerular filtration rate (creatinine); CRC cis rs7591163 1.000 rs2056566 chr2:228713241 G/A cg22079747 chr2:228736145 WDR69 -0.44 -5.88 -0.31 1.01e-8 Blood pressure; CRC cis rs751728 0.664 rs943475 chr6:33749978 C/T cg25922239 chr6:33757077 LEMD2 -0.46 -6.76 -0.35 6.2e-11 Crohn's disease; CRC cis rs478304 0.817 rs524475 chr11:65518065 T/A cg27068330 chr11:65405492 SIPA1 0.44 6.55 0.34 2.26e-10 Acne (severe); CRC cis rs9361491 0.657 rs9361426 chr6:79457550 G/T cg05283184 chr6:79620031 NA -0.38 -5.76 -0.3 1.96e-8 Intelligence (multi-trait analysis); CRC cis rs9976767 0.792 rs2839508 chr21:43845294 A/G cg23042151 chr21:43824109 UBASH3A -0.35 -6.19 -0.32 1.79e-9 Type 1 diabetes; CRC cis rs1190552 0.846 rs3783382 chr14:102965437 A/T cg18135206 chr14:102964638 TECPR2 0.52 6.18 0.32 1.88e-9 Blood protein levels; CRC cis rs13108904 0.935 rs1732102 chr4:1277924 T/C cg24560729 chr4:1342394 KIAA1530 -0.31 -5.66 -0.3 3.25e-8 Obesity-related traits; CRC cis rs2228479 0.850 rs17227064 chr16:89816314 A/G cg06656553 chr16:89960601 TCF25 -0.69 -5.74 -0.3 2.15e-8 Skin colour saturation; CRC cis rs2976388 0.556 rs4736321 chr8:143822194 C/T cg22687807 chr8:143858763 LYNX1 -0.44 -6.86 -0.35 3.4e-11 Urinary tract infection frequency; CRC cis rs1218582 0.596 rs4845676 chr1:154827861 C/G cg16680214 chr1:154839983 KCNN3 -0.41 -7.35 -0.38 1.63e-12 Prostate cancer; CRC cis rs9649465 1.000 rs10238422 chr7:123353708 G/C cg03229431 chr7:123269106 ASB15 -0.37 -5.69 -0.3 2.82e-8 Migraine; CRC cis rs2404602 1.000 rs4886818 chr15:76880939 G/A cg22467129 chr15:76604101 ETFA -0.36 -6.05 -0.32 4.02e-9 Blood metabolite levels; CRC cis rs9463078 0.656 rs227843 chr6:44691703 A/G cg25276700 chr6:44698697 NA 0.25 5.93 0.31 7.62e-9 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; CRC trans rs2228479 0.850 rs2302162 chr16:89845287 A/G cg24644049 chr4:85504048 CDS1 0.92 7.68 0.39 1.79e-13 Skin colour saturation; CRC cis rs11123170 0.650 rs2289897 chr2:113977454 G/A cg25243455 chr2:114033360 PAX8;LOC440839 -0.31 -6.03 -0.32 4.39e-9 Renal function-related traits (BUN); CRC trans rs8002861 0.727 rs9533652 chr13:44419532 A/G cg17145862 chr1:211918768 LPGAT1 -0.49 -8.18 -0.41 6.32e-15 Leprosy; CRC cis rs7208859 0.623 rs9912283 chr17:29110373 A/G cg13385521 chr17:29058706 SUZ12P 0.73 8.4 0.42 1.39e-15 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs35146811 0.700 rs866500 chr7:99840461 A/G cg13334819 chr7:99746414 C7orf59 0.57 6.78 0.35 5.45e-11 Coronary artery disease; CRC cis rs4713118 0.513 rs149955 chr6:28036225 G/C cg15786705 chr6:28176104 NA 0.59 8.42 0.42 1.21e-15 Parkinson's disease; CRC cis rs7208859 0.673 rs78799101 chr17:29215160 A/T cg14008862 chr17:28927542 LRRC37B2 0.53 5.64 0.3 3.61e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs2976388 0.609 rs2572907 chr8:143801938 G/A cg15511327 chr8:143859410 LYNX1 0.39 6.97 0.36 1.79e-11 Urinary tract infection frequency; CRC cis rs1065656 0.581 rs1065666 chr16:1839134 T/C cg00046913 chr16:1877150 HAGH;FAHD1 0.52 5.75 0.3 2.04e-8 Insulin-like growth factors; CRC cis rs6741819 0.955 rs4669124 chr2:7149737 A/G cg27144453 chr2:7172511 RNF144A -0.43 -6.43 -0.33 4.48e-10 Response to antipsychotic treatment; CRC cis rs10504229 0.683 rs17194995 chr8:58109220 A/C cg11062466 chr8:58055876 NA -0.5 -6.27 -0.33 1.16e-9 Developmental language disorder (linguistic errors); CRC cis rs17234274 0.644 rs1947940 chr11:23221511 A/C cg05245346 chr11:23248277 NA 0.35 5.75 0.3 2.03e-8 Cancer; CRC cis rs910873 0.505 rs6059961 chr20:33231490 T/C cg08999081 chr20:33150536 PIGU 0.5 6.15 0.32 2.22e-9 Melanoma; CRC cis rs6604026 0.656 rs9439948 chr1:93370800 A/G cg17283838 chr1:93427260 FAM69A -0.43 -5.79 -0.3 1.61e-8 Multiple sclerosis; CRC cis rs13096480 0.583 rs17598137 chr3:49891362 G/T cg16563178 chr3:50358443 HYAL2 0.4 6.08 0.32 3.36e-9 Intelligence (multi-trait analysis); CRC cis rs9926296 0.605 rs1800287 chr16:89858525 C/G cg21285383 chr16:89894308 SPIRE2 0.35 6.01 0.31 4.92e-9 Vitiligo; CRC cis rs1552244 0.572 rs58223482 chr3:10169746 G/C cg10729496 chr3:10149963 C3orf24 0.48 5.63 0.3 3.81e-8 Alzheimer's disease; CRC cis rs4253772 0.591 rs6007732 chr22:46652303 A/T cg09491104 chr22:46646882 C22orf40 -0.51 -7.84 -0.4 6.16e-14 LDL cholesterol;Cholesterol, total; CRC cis rs2549003 0.966 rs2706386 chr5:131832687 C/T cg02551604 chr5:131831745 NA 0.6 9.2 0.45 4.2e-18 Asthma (sex interaction); CRC cis rs12594515 1.000 rs8025258 chr15:45987554 C/A cg22117107 chr15:45993392 NA -0.44 -9.09 -0.45 9.56e-18 Waist circumference;Weight; CRC trans rs735172 0.765 rs16837649 chr4:5756362 C/T cg10228456 chr14:30680170 NA -0.41 -5.97 -0.31 6.1e-9 Prostate cancer (SNP x SNP interaction); CRC cis rs9768139 0.683 rs4909178 chr7:158117752 T/A cg06219351 chr7:158114137 PTPRN2 -0.54 -8.17 -0.41 6.55e-15 Calcium levels; CRC cis rs1218582 0.772 rs4845682 chr1:154877105 T/C cg16680214 chr1:154839983 KCNN3 -0.45 -8.95 -0.44 2.64e-17 Prostate cancer; CRC cis rs9611565 0.649 rs5751144 chr22:42128097 A/G cg03806693 chr22:41940476 POLR3H -0.67 -9.56 -0.47 2.87e-19 Vitiligo; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg05744073 chr17:1953268 MIR132 0.52 7.5 0.38 5.86e-13 Response to antipsychotic treatment; CRC cis rs9487051 0.872 rs1111865 chr6:109610863 A/G cg01475377 chr6:109611718 NA 0.5 9.46 0.46 6.14e-19 Reticulocyte fraction of red cells; CRC cis rs13118159 0.550 rs4974617 chr4:1373658 T/C cg19318889 chr4:1322082 MAEA 0.69 10.11 0.49 4.32e-21 Longevity; CRC cis rs9902453 0.904 rs9894893 chr17:28270350 C/T cg26525008 chr17:28256777 EFCAB5;SSH2 0.7 11.54 0.54 4.14e-26 Coffee consumption (cups per day); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg10926516 chr16:84151109 MBTPS1 0.43 6.03 0.32 4.52e-9 Response to antipsychotic treatment; CRC cis rs861020 0.771 rs674804 chr1:210014603 C/G cg05527609 chr1:210001259 C1orf107 1.08 14.74 0.63 4.15e-38 Orofacial clefts; CRC cis rs1005277 0.579 rs2474567 chr10:38382492 C/T cg17219203 chr10:38645113 HSD17B7P2 -0.41 -5.81 -0.3 1.51e-8 Extrinsic epigenetic age acceleration; CRC cis rs763121 1.000 rs86796 chr22:38881454 A/C cg06544989 chr22:39130855 UNC84B -0.47 -7.39 -0.38 1.26e-12 Menopause (age at onset); CRC cis rs67340775 0.541 rs200973 chr6:27858421 A/G cg15845792 chr6:28175446 NA 0.8 8.48 0.42 7.73e-16 Lung cancer in ever smokers; CRC cis rs12580194 0.593 rs61957933 chr12:55744710 T/G cg23425280 chr12:56401806 NA 0.44 5.61 0.3 4.19e-8 Cancer; CRC cis rs10504229 0.683 rs55645894 chr8:58116145 A/G cg22535103 chr8:58192502 C8orf71 -0.7 -9.34 -0.46 1.47e-18 Developmental language disorder (linguistic errors); CRC cis rs4588572 0.686 rs2362823 chr5:77693623 A/G cg11446398 chr5:77624930 NA -0.48 -6.71 -0.35 8.57e-11 Triglycerides; CRC cis rs5769765 0.819 rs9616377 chr22:50310880 T/C cg04121214 chr22:50244548 NA 0.42 5.87 0.31 1.05e-8 Schizophrenia; CRC cis rs898097 0.841 rs2271918 chr17:80861206 A/G cg03160526 chr17:80928410 B3GNTL1 -0.43 -6.0 -0.31 5.06e-9 Breast cancer; CRC cis rs17270561 0.636 rs6923367 chr6:25745852 A/T cg17691542 chr6:26056736 HIST1H1C 0.69 8.63 0.43 2.57e-16 Iron status biomarkers; CRC cis rs12580194 0.556 rs73119000 chr12:55736662 G/A cg23425280 chr12:56401806 NA 0.47 6.02 0.31 4.68e-9 Cancer; CRC trans rs7615952 0.558 rs7641353 chr3:125339879 T/C cg02007433 chr3:129722099 NA -0.61 -9.12 -0.45 7.74e-18 Blood pressure (smoking interaction); CRC trans rs7615952 0.866 rs1976459 chr3:125647486 A/T cg16558177 chr4:4109446 NA -0.48 -6.23 -0.32 1.41e-9 Blood pressure (smoking interaction); CRC cis rs2456568 0.802 rs8181578 chr11:93637442 G/A cg26875233 chr11:93583750 C11orf90 -0.32 -6.27 -0.33 1.15e-9 Response to serotonin reuptake inhibitors in major depressive disorder; CRC cis rs7945705 0.967 rs10769968 chr11:8907583 G/C cg21881798 chr11:8931708 C11orf17;ST5 0.68 10.74 0.51 2.95e-23 Hemoglobin concentration; CRC cis rs7647973 1.000 rs7619789 chr3:49476263 T/C cg20833759 chr3:49053208 WDR6;DALRD3 0.55 8.47 0.42 8.41e-16 Menarche (age at onset); CRC cis rs9326248 0.731 rs90192 chr11:117059347 C/T cg26566898 chr11:117069891 TAGLN 0.35 5.96 0.31 6.57e-9 Blood protein levels; CRC cis rs9826463 0.582 rs116196326 chr3:142059684 A/T cg20824294 chr3:142316082 PLS1 0.35 5.67 0.3 3.1e-8 QRS duration in Tripanosoma cruzi seropositivity; CRC cis rs3018066 0.666 rs28765420 chr4:107034766 T/C cg01869342 chr4:106983673 TBCK 0.42 5.66 0.3 3.38e-8 Cancer; CRC cis rs875971 0.862 rs778680 chr7:65840414 G/A cg11764359 chr7:65958608 NA 0.59 9.08 0.45 1.06e-17 Aortic root size; CRC cis rs9467603 1.000 rs6940698 chr6:25821580 A/G cg16898833 chr6:26189333 HIST1H4D -0.83 -6.72 -0.35 7.97e-11 Intelligence (multi-trait analysis); CRC cis rs7666738 1.000 rs2865983 chr4:99033352 C/T cg03676636 chr4:99064102 C4orf37 0.23 6.45 0.34 3.97e-10 Colonoscopy-negative controls vs population controls; CRC cis rs11758351 0.660 rs16891443 chr6:26221937 A/C cg10723962 chr6:26240782 HIST1H4F -0.38 -6.09 -0.32 3.14e-9 Gout;Renal underexcretion gout; CRC trans rs9630182 0.561 rs1562436 chr11:13462056 G/A cg13741668 chr9:85679694 NA 0.38 6.19 0.32 1.78e-9 Bone mineral density; CRC cis rs4272321 1 rs4272321 chr7:157951835 A/G cg23602909 chr7:157956050 PTPRN2 -0.87 -17.28 -0.69 4.41e-48 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; CRC cis rs1401999 0.836 rs34571027 chr3:183726644 T/C cg05044414 chr3:183734942 ABCC5 0.43 7.35 0.38 1.62e-12 Anterior chamber depth; CRC cis rs6582630 0.539 rs4882324 chr12:38499180 T/C cg13010199 chr12:38710504 ALG10B -0.44 -6.23 -0.32 1.46e-9 Drug-induced liver injury (flucloxacillin); CRC cis rs9911578 1.000 rs3744108 chr17:56585872 G/C cg05425664 chr17:57184151 TRIM37 0.51 8.08 0.41 1.25e-14 Intelligence (multi-trait analysis); CRC cis rs2180341 1.000 rs6903878 chr6:127638600 C/G cg27446573 chr6:127587934 RNF146 0.98 14.38 0.62 9.93e-37 Breast cancer; CRC cis rs1997103 1.000 rs6973337 chr7:55411534 T/C cg17469321 chr7:55412551 NA 0.72 11.16 0.52 9.35e-25 QRS interval (sulfonylurea treatment interaction); CRC cis rs9372498 0.764 rs9489372 chr6:118726243 T/C cg18833306 chr6:118973337 C6orf204 0.46 5.64 0.3 3.57e-8 Diastolic blood pressure; CRC cis rs782590 0.764 rs935177 chr2:55826761 C/G cg18811423 chr2:55921094 PNPT1 0.79 13.89 0.61 7.72e-35 Metabolic syndrome; CRC trans rs1814175 0.645 rs10128731 chr11:50023554 G/T cg15704280 chr7:45808275 SEPT13 -0.93 -17.22 -0.69 7.71e-48 Height; CRC cis rs10901296 0.660 rs2696141 chr9:133754099 G/T cg01000188 chr9:133769184 QRFP 0.57 6.6 0.34 1.67e-10 Bilirubin levels; CRC cis rs4919694 1.000 rs7099987 chr10:104807926 C/T cg04362960 chr10:104952993 NT5C2 1.09 10.36 0.5 5.71e-22 Arsenic metabolism; CRC cis rs7927592 0.763 rs10896340 chr11:68312645 A/G cg01657329 chr11:68192670 LRP5 0.55 9.13 0.45 7.21e-18 Total body bone mineral density; CRC cis rs2839186 0.739 rs2280958 chr21:47642016 C/T cg11766577 chr21:47581405 C21orf56 -0.51 -8.33 -0.42 2.24e-15 Testicular germ cell tumor; CRC cis rs3733585 0.753 rs1122141 chr4:9947278 T/C cg00071950 chr4:10020882 SLC2A9 -0.62 -11.06 -0.52 2.19e-24 Cleft plate (environmental tobacco smoke interaction); CRC cis rs7959452 0.868 rs12812860 chr12:69746671 T/C cg20891283 chr12:69753455 YEATS4 0.75 12.24 0.56 1.19e-28 Blood protein levels; CRC trans rs11039798 0.557 rs4441015 chr11:49027070 A/G cg02254774 chr11:50257496 LOC441601 0.55 6.06 0.32 3.77e-9 Axial length; CRC cis rs6968419 0.642 rs67251819 chr7:115905586 T/C cg02561103 chr7:115862891 TES -0.43 -6.49 -0.34 3.18e-10 Intraocular pressure; CRC cis rs9326248 0.559 rs573549 chr11:116736679 A/G cg11861562 chr11:117069780 TAGLN 0.26 5.81 0.3 1.51e-8 Blood protein levels; CRC cis rs6952808 0.656 rs73048919 chr7:2103637 C/A cg22963979 chr7:1858916 MAD1L1 -0.49 -6.9 -0.36 2.73e-11 Bipolar disorder and schizophrenia; CRC cis rs12477438 0.539 rs720228 chr2:99704547 A/G cg26064155 chr2:99771622 LIPT1;TSGA10 0.9 16.78 0.68 4.47e-46 Chronic sinus infection; CRC cis rs1656402 0.906 rs1190435 chr2:233424106 A/G cg03852847 chr2:233439513 NA 0.46 7.87 0.4 5.19e-14 Non-small cell lung cancer (survival); CRC cis rs13394619 1.000 rs13394619 chr2:11727507 A/G cg07314298 chr2:11723111 GREB1 0.49 8.1 0.41 1.06e-14 Endometriosis; CRC cis rs2836950 0.501 rs2056844 chr21:40670460 G/C cg17971929 chr21:40555470 PSMG1 -0.56 -8.16 -0.41 7.16e-15 Menarche (age at onset); CRC trans rs3960554 0.808 rs78811105 chr7:75702795 G/A cg19862616 chr7:65841803 NCRNA00174 0.73 8.61 0.43 3.13e-16 Eotaxin levels; CRC cis rs889312 0.500 rs33328 chr5:56143419 T/C cg18230493 chr5:56204884 C5orf35 -0.39 -5.84 -0.31 1.27e-8 Breast cancer;Breast cancer (early onset); CRC cis rs9868809 0.772 rs9812200 chr3:48695667 A/G cg07636037 chr3:49044803 WDR6 0.65 6.7 0.35 8.98e-11 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; CRC cis rs16975963 0.644 rs1478462 chr19:38147025 A/G cg15135657 chr19:38346511 NA -0.47 -6.56 -0.34 2.09e-10 Longevity; CRC cis rs1451375 1.000 rs1451374 chr7:50622653 G/A cg14593290 chr7:50529359 DDC 0.55 7.64 0.39 2.35e-13 Malaria; CRC cis rs896854 0.631 rs10097617 chr8:95961626 T/C cg23172400 chr8:95962367 TP53INP1 -0.5 -8.41 -0.42 1.3e-15 Type 2 diabetes; CRC cis rs1577917 0.958 rs12192033 chr6:86472559 T/A cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.53 -7.13 -0.37 6.51e-12 Response to antipsychotic treatment; CRC cis rs875971 0.862 rs2901152 chr7:65765004 G/A cg11764359 chr7:65958608 NA -0.59 -8.72 -0.43 1.38e-16 Aortic root size; CRC cis rs7208859 0.673 rs56846352 chr17:29119188 C/T cg14008862 chr17:28927542 LRRC37B2 0.5 5.76 0.3 1.89e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs6582630 0.503 rs4882293 chr12:38388200 G/C cg26384229 chr12:38710491 ALG10B -0.53 -7.78 -0.39 9.24e-14 Drug-induced liver injury (flucloxacillin); CRC cis rs79387448 0.745 rs72995658 chr2:103176773 A/G cg00507830 chr2:103233733 NA 0.55 6.16 0.32 2.07e-9 Gut microbiota (bacterial taxa); CRC cis rs6433857 0.627 rs1406259 chr2:181522879 T/G cg23363182 chr2:181467187 NA -0.48 -7.38 -0.38 1.29e-12 Body mass index; CRC cis rs6445967 1.000 rs13325699 chr3:58286870 T/C cg23715586 chr3:58305044 RPP14 0.36 6.1 0.32 3.04e-9 Platelet count; CRC cis rs11031096 0.502 rs1442726 chr11:4094748 G/C cg18678763 chr11:4115507 RRM1 -0.54 -8.65 -0.43 2.34e-16 Mean corpuscular volume;Mean corpuscular hemoglobin; CRC cis rs10751667 0.666 rs4074233 chr11:977685 G/A ch.11.42038R chr11:967971 AP2A2 0.58 9.98 0.48 1.16e-20 Alzheimer's disease (late onset); CRC cis rs1572438 0.899 rs9392198 chr6:860561 T/G cg13447295 chr6:887704 NA -0.46 -6.5 -0.34 2.98e-10 Aging; CRC cis rs10782582 0.609 rs11161848 chr1:76367722 A/G cg10523679 chr1:76189770 ACADM -0.42 -5.96 -0.31 6.6e-9 Daytime sleep phenotypes; CRC cis rs9443645 0.869 rs11754419 chr6:79729648 A/G cg09184832 chr6:79620586 NA -0.51 -9.34 -0.46 1.52e-18 Intelligence (multi-trait analysis); CRC trans rs10506458 0.834 rs12426860 chr12:63387948 C/T cg03429785 chr15:59498649 MYO1E;LDHAL6B -1.46 -21.13 -0.76 3.29e-63 Hemostatic factors and hematological phenotypes; CRC cis rs9807989 0.524 rs4851576 chr2:103028895 C/T cg03938978 chr2:103052716 IL18RAP 0.59 10.13 0.49 3.5e-21 Asthma; CRC cis rs7618915 0.571 rs34115864 chr3:52612178 A/G cg18404041 chr3:52824283 ITIH1 -0.43 -8.97 -0.44 2.23e-17 Bipolar disorder; CRC cis rs9399137 0.507 rs4895437 chr6:135317354 G/A cg24558204 chr6:135376177 HBS1L 0.62 9.46 0.46 5.88e-19 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; CRC cis rs10919791 0.501 rs4915189 chr1:199916450 C/A cg07208853 chr1:200005219 NR5A2 0.23 5.94 0.31 7.18e-9 Pancreatic cancer; CRC cis rs4664293 0.867 rs7566802 chr2:160584991 A/G cg08347373 chr2:160653686 CD302 -0.47 -7.43 -0.38 9.32e-13 Monocyte percentage of white cells; CRC cis rs7647973 1.000 rs892974 chr3:49398514 C/A cg20833759 chr3:49053208 WDR6;DALRD3 0.61 9.23 0.45 3.34e-18 Menarche (age at onset); CRC cis rs1577917 0.958 rs11756510 chr6:86699794 G/A cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.52 -6.53 -0.34 2.57e-10 Response to antipsychotic treatment; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg06734816 chr6:116422381 NT5DC1 0.47 6.7 0.35 9.06e-11 Response to antipsychotic treatment; CRC trans rs4785204 1.000 rs13339262 chr16:50091383 C/A cg01860778 chr20:26189510 MIR663 0.47 5.98 0.31 5.74e-9 Esophageal cancer (squamous cell); CRC cis rs10128264 0.902 rs1250584 chr10:80976442 G/T cg18737081 chr10:80999807 ZMIZ1 -0.36 -6.29 -0.33 1.04e-9 Response to methotrexate in juvenile idiopathic arthritis; CRC cis rs7044106 0.762 rs10760115 chr9:123476952 G/A cg09586646 chr9:123605570 PSMD5;LOC253039 0.63 9.16 0.45 5.67e-18 Hip circumference adjusted for BMI; CRC cis rs9322193 0.923 rs12526675 chr6:150050676 A/C cg07701084 chr6:150067640 NUP43 -0.57 -8.14 -0.41 8.42e-15 Lung cancer; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg11371493 chr20:30795352 POFUT1;PLAGL2 0.43 6.28 0.33 1.04e-9 Response to antipsychotic treatment; CRC cis rs2404602 0.583 rs12898415 chr15:76574232 C/T cg03037974 chr15:76606532 NA 0.82 16.47 0.67 7.08e-45 Blood metabolite levels; CRC cis rs55823223 0.564 rs1463485 chr17:73851791 C/G cg08125733 chr17:73851984 WBP2 0.7 9.05 0.45 1.31e-17 Psoriasis; CRC cis rs11204677 1 rs11204677 chr1:150574695 C/G cg18016565 chr1:150552671 MCL1 -0.47 -6.98 -0.36 1.59e-11 Monocyte percentage of white cells;Granulocyte percentage of myeloid white cells; CRC cis rs6598955 0.585 rs12138111 chr1:26590432 G/A cg04990556 chr1:26633338 UBXN11 0.55 5.93 0.31 7.84e-9 Obesity-related traits; CRC cis rs4713118 0.588 rs200994 chr6:27813813 A/C cg25164649 chr6:28176230 NA -0.61 -7.98 -0.4 2.43e-14 Parkinson's disease; CRC cis rs66573146 0.831 rs56081162 chr4:6989718 C/T cg00086871 chr4:6988644 TBC1D14 1.01 8.33 0.42 2.18e-15 Granulocyte percentage of myeloid white cells; CRC cis rs7527798 0.571 rs7531923 chr1:207833336 T/G cg09232269 chr1:207846808 CR1L -0.52 -8.65 -0.43 2.26e-16 Erythrocyte sedimentation rate; CRC cis rs13191362 1.000 rs13200329 chr6:163004418 G/A cg06582575 chr6:163149167 PACRG;PARK2 0.73 10.55 0.5 1.3e-22 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC trans rs9329221 0.537 rs2062331 chr8:9979992 C/T cg06636001 chr8:8085503 FLJ10661 -0.5 -7.51 -0.38 5.57e-13 Neuroticism; CRC cis rs6088580 0.634 rs6059850 chr20:33044784 C/G cg24642439 chr20:33292090 TP53INP2 0.37 6.29 0.33 1.02e-9 Glomerular filtration rate (creatinine); CRC cis rs41271473 0.526 rs72765760 chr1:228743222 G/A cg16512390 chr1:228756714 NA 0.63 7.14 0.37 6.12e-12 Chronic lymphocytic leukemia; CRC cis rs12711979 0.765 rs13028529 chr2:3825467 C/T cg17052675 chr2:3827356 NA -0.56 -10.39 -0.5 4.84e-22 Itch intensity from mosquito bite adjusted by bite size; CRC cis rs28386778 0.830 rs2584625 chr17:61903445 G/C cg07362569 chr17:61921086 SMARCD2 0.37 5.66 0.3 3.23e-8 Prudent dietary pattern; CRC cis rs1555895 0.576 rs752375 chr10:863329 C/T cg10556349 chr10:835070 NA -0.34 -6.47 -0.34 3.52e-10 Survival in rectal cancer; CRC cis rs1218582 0.688 rs58629129 chr1:154910930 T/C cg16680214 chr1:154839983 KCNN3 -0.49 -8.76 -0.43 1.06e-16 Prostate cancer; CRC cis rs10540 1.000 rs12419766 chr11:503710 C/T cg21784768 chr11:537496 LRRC56 -0.69 -6.56 -0.34 2.11e-10 Body mass index; CRC cis rs6912958 0.712 rs7746465 chr6:88348996 T/G cg12350822 chr6:88032061 C6orf162;GJB7 -0.32 -5.98 -0.31 5.68e-9 Monocyte percentage of white cells; CRC cis rs10504229 0.728 rs72650868 chr8:58155568 G/C cg08219700 chr8:58056026 NA 0.45 5.74 0.3 2.11e-8 Developmental language disorder (linguistic errors); CRC cis rs6484504 0.576 rs176373 chr11:31136026 G/T cg14844989 chr11:31128820 NA -0.34 -5.92 -0.31 8.08e-9 Red blood cell count; CRC cis rs10751667 1.000 rs6597972 chr11:928402 C/T cg23136738 chr11:925521 AP2A2 -0.52 -8.51 -0.42 6.44e-16 Alzheimer's disease (late onset); CRC cis rs7614311 0.731 rs56126667 chr3:63866286 A/G cg22134162 chr3:63841271 THOC7 -0.58 -6.03 -0.32 4.43e-9 Lung function (FVC);Lung function (FEV1); CRC cis rs9910055 0.530 rs2269908 chr17:42294198 G/C cg13607699 chr17:42295918 UBTF 0.81 14.42 0.62 6.85e-37 Total body bone mineral density; CRC cis rs769267 0.930 rs2301786 chr19:19413947 A/G cg17414380 chr19:19431394 KIAA0892;SF4 0.42 5.68 0.3 2.89e-8 Tonsillectomy; CRC cis rs4665809 1.000 rs10202478 chr2:26276049 T/C cg26119090 chr2:26468346 HADHA;HADHB -0.62 -7.91 -0.4 3.86e-14 Gut microbiome composition (summer); CRC cis rs9372498 0.536 rs9481833 chr6:118919631 G/A cg10217327 chr6:118973057 C6orf204 0.52 5.92 0.31 8.31e-9 Diastolic blood pressure; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg06530028 chr7:143078179 ZYX 0.45 6.2 0.32 1.69e-9 Response to antipsychotic treatment; CRC cis rs243505 0.559 rs2072408 chr7:148508197 A/G cg09806900 chr7:148480153 CUL1 0.58 8.22 0.41 4.75e-15 Inflammatory bowel disease;Crohn's disease; CRC cis rs875971 0.825 rs7384021 chr7:66077904 A/G cg00343986 chr7:65444356 GUSB -0.46 -6.27 -0.33 1.16e-9 Aortic root size; CRC cis rs4713118 0.869 rs6922574 chr6:27693003 A/T cg26587870 chr6:27730563 NA -0.46 -7.09 -0.36 8.03e-12 Parkinson's disease; CRC cis rs6459788 0.720 rs11768765 chr7:157253133 C/T cg03453431 chr7:157225567 NA -0.56 -8.78 -0.44 9.34e-17 Epstein-Barr virus copy number in lymphoblastoid cell lines; CRC trans rs8089364 0.917 rs12957325 chr18:57884616 T/C cg05871254 chr17:14213225 HS3ST3B1 -0.43 -5.97 -0.31 6.12e-9 Type 2 diabetes;Body mass index; CRC cis rs13118159 0.801 rs1128427 chr4:1330759 T/C cg23123621 chr4:1343375 KIAA1530 0.37 6.35 0.33 7.32e-10 Longevity; CRC trans rs1656966 1.000 rs1656966 chr3:186466252 C/T cg22879676 chr17:81009871 B3GNTL1 0.4 6.15 0.32 2.22e-9 Myopia (pathological); CRC cis rs9911578 1.000 rs172565 chr17:56808996 A/T cg05425664 chr17:57184151 TRIM37 -0.5 -7.93 -0.4 3.41e-14 Intelligence (multi-trait analysis); CRC cis rs7309 0.935 rs11884495 chr2:162059969 A/T cg16506815 chr2:162101123 NA 0.51 8.56 0.43 4.28e-16 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Educational attainment; CRC cis rs11628318 0.614 rs7143048 chr14:103119800 C/T cg23071808 chr14:103021642 NA 0.63 7.04 0.36 1.14e-11 Platelet count; CRC cis rs853679 0.517 rs9380056 chr6:28104476 C/T cg02631126 chr6:28058918 ZSCAN12L1 0.29 5.89 0.31 9.41e-9 Depression; CRC cis rs7914558 0.966 rs746293 chr10:104897254 G/T cg04362960 chr10:104952993 NT5C2 0.59 8.75 0.43 1.14e-16 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs4563143 0.663 rs10406794 chr19:29228056 C/T cg12667521 chr19:29218732 NA 0.51 8.17 0.41 6.61e-15 Methadone dose in opioid dependence; CRC cis rs2228479 0.850 rs11640209 chr16:89807828 C/A cg06656553 chr16:89960601 TCF25 -0.68 -5.71 -0.3 2.55e-8 Skin colour saturation; CRC cis rs28551159 1 rs28551159 chr6:26376368 A/G cg16898833 chr6:26189333 HIST1H4D 0.73 6.15 0.32 2.21e-9 Urinary tract infection frequency; CRC cis rs2952156 0.920 rs2934956 chr17:37830447 T/A cg07936489 chr17:37558343 FBXL20 -0.42 -5.99 -0.31 5.51e-9 Asthma; CRC cis rs6676180 0.555 rs871665 chr1:119772663 C/T cg05756136 chr1:119680316 WARS2 -0.45 -6.59 -0.34 1.73e-10 Monobrow; CRC cis rs4566357 0.615 rs4675140 chr2:227908665 C/T cg11843606 chr2:227700838 RHBDD1 -0.45 -6.83 -0.35 4.02e-11 Coronary artery disease; CRC cis rs9916302 0.861 rs9903363 chr17:37499604 C/G cg00129232 chr17:37814104 STARD3 0.54 8.03 0.4 1.73e-14 Glomerular filtration rate (creatinine); CRC cis rs6500395 1.000 rs871902 chr16:48593779 A/G cg04672837 chr16:48644449 N4BP1 0.44 6.5 0.34 2.95e-10 Response to tocilizumab in rheumatoid arthritis; CRC cis rs1670533 1.000 rs604597 chr4:1094151 G/A cg27284194 chr4:1044797 NA -0.51 -6.34 -0.33 7.53e-10 Recombination rate (females); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg08306513 chr11:120040083 NA 0.42 6.02 0.31 4.58e-9 Response to antipsychotic treatment; CRC cis rs9399135 0.967 rs9389261 chr6:135371148 C/G cg22676075 chr6:135203613 NA 0.38 5.86 0.31 1.11e-8 Red blood cell count; CRC trans rs2303319 0.504 rs12473497 chr2:162433766 T/C cg09481857 chr22:21368659 P2RX6;MGC16703 -0.66 -6.14 -0.32 2.36e-9 Cognitive function; CRC cis rs6921919 0.515 rs1339898 chr6:28395506 C/T cg03623178 chr6:28175578 NA 0.41 5.66 0.3 3.35e-8 Autism spectrum disorder or schizophrenia; CRC cis rs17021463 0.807 rs6847989 chr4:95277099 A/C cg11021082 chr4:95130006 SMARCAD1 0.49 7.12 0.37 6.77e-12 Testicular germ cell tumor; CRC cis rs769267 1.000 rs1009136 chr19:19440428 A/G cg02546618 chr19:19431379 KIAA0892;SF4 -0.47 -6.54 -0.34 2.3e-10 Tonsillectomy; CRC cis rs28493229 0.881 rs59459325 chr19:41175390 C/T cg21869046 chr19:41225005 ITPKC 0.44 6.47 0.34 3.57e-10 Kawasaki disease; CRC trans rs2243480 1.000 rs35820085 chr7:65442758 C/T cg10756647 chr7:56101905 PSPH 0.72 7.69 0.39 1.71e-13 Diabetic kidney disease; CRC cis rs66887589 0.616 rs6822808 chr4:120217365 C/A cg09307838 chr4:120376055 NA 0.56 8.48 0.42 7.8e-16 Diastolic blood pressure; CRC cis rs1534696 1.000 rs1534696 chr7:26397239 A/C cg12965553 chr7:26403802 SNX10 -0.36 -5.94 -0.31 7.06e-9 Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour); CRC cis rs10493773 0.775 rs11161662 chr1:86185040 A/G cg00734567 chr1:86172782 ZNHIT6 -0.4 -5.65 -0.3 3.47e-8 Urate levels in overweight individuals; CRC cis rs12188164 0.930 rs72717436 chr5:448291 C/A cg16322479 chr5:444228 EXOC3;C5orf55 0.5 8.06 0.41 1.43e-14 Cystic fibrosis severity; CRC cis rs10504229 0.683 rs17194995 chr8:58109220 A/C cg02725872 chr8:58115012 NA 0.57 8.32 0.42 2.31e-15 Developmental language disorder (linguistic errors); CRC cis rs10504229 1.000 rs73609762 chr8:58192695 A/G cg01721255 chr8:58191610 C8orf71 0.49 6.17 0.32 2e-9 Developmental language disorder (linguistic errors); CRC cis rs2204008 0.728 rs11495375 chr12:38282631 G/A cg13010199 chr12:38710504 ALG10B 0.45 5.75 0.3 2.07e-8 Bladder cancer; CRC cis rs2153535 0.504 rs9328472 chr6:8470848 G/A cg07606381 chr6:8435919 SLC35B3 0.68 10.9 0.51 8.26e-24 Motion sickness; CRC cis rs4713118 0.527 rs9461433 chr6:28095172 C/T cg06470822 chr6:28175283 NA 1.0 13.33 0.59 1.06e-32 Parkinson's disease; CRC cis rs28386778 0.897 rs2665796 chr17:61923716 G/C cg06601766 chr17:61851465 DDX42;CCDC47 0.42 5.8 0.3 1.53e-8 Prudent dietary pattern; CRC cis rs12594515 1.000 rs7173144 chr15:45991196 A/G cg19682013 chr15:45996608 NA 0.32 6.53 0.34 2.51e-10 Waist circumference;Weight; CRC cis rs501120 0.584 rs2804031 chr10:44702928 T/G cg09554077 chr10:44749378 NA 0.67 7.47 0.38 7.27e-13 Coronary artery disease;Coronary heart disease; CRC trans rs5756813 1.000 rs1129448 chr22:38170026 G/A cg19894588 chr14:64061835 NA 0.59 8.83 0.44 6.54e-17 Optic cup area;Vertical cup-disc ratio; CRC cis rs9859260 0.744 rs3933 chr3:195784997 C/T cg12923728 chr3:195709715 SDHAP1 0.47 6.47 0.34 3.49e-10 Mean corpuscular volume; CRC cis rs35110281 0.626 rs162389 chr21:44936227 T/C cg04455712 chr21:45112962 RRP1B 0.39 7.22 0.37 3.59e-12 Mean corpuscular volume; CRC cis rs3736485 0.844 rs28415556 chr15:51760474 G/A cg08986416 chr15:51914746 DMXL2 -0.46 -6.5 -0.34 2.95e-10 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg10352719 chr14:24769404 DHRS1;C14orf21 0.48 6.41 0.33 5.16e-10 Thyroid stimulating hormone; CRC cis rs9916302 0.660 rs4795379 chr17:37674683 T/G cg00129232 chr17:37814104 STARD3 -0.58 -7.27 -0.37 2.6e-12 Glomerular filtration rate (creatinine); CRC cis rs7937682 0.632 rs11608193 chr11:111732215 T/C cg19812747 chr11:111475976 SIK2 0.42 6.07 0.32 3.53e-9 Primary sclerosing cholangitis; CRC cis rs7089973 0.604 rs10885620 chr10:116630048 A/T cg23260525 chr10:116636907 FAM160B1 0.37 8.88 0.44 4.48e-17 Bipolar disorder or attention deficit hyperactivity disorder; CRC cis rs798554 0.797 rs1182184 chr7:2872446 G/A cg19717773 chr7:2847554 GNA12 -0.48 -6.85 -0.35 3.59e-11 Height; CRC cis rs1059312 0.771 rs11059922 chr12:129290418 C/T cg21616243 chr12:129299702 MGC16384;SLC15A4 -0.75 -13.36 -0.59 8.31e-33 Systemic lupus erythematosus; CRC cis rs6952808 0.929 rs2280548 chr7:1976667 G/T cg00106254 chr7:1943704 MAD1L1 -0.47 -6.5 -0.34 2.96e-10 Bipolar disorder and schizophrenia; CRC cis rs9322193 0.884 rs933055 chr6:150130837 A/G cg05861140 chr6:150128134 PCMT1 -0.43 -7.01 -0.36 1.39e-11 Lung cancer; CRC cis rs7737355 0.947 rs31240 chr5:130811146 T/A cg06307176 chr5:131281290 NA 0.42 6.27 0.33 1.11e-9 Life satisfaction; CRC trans rs7618501 0.633 rs6772095 chr3:49978069 C/T cg21659725 chr3:3221576 CRBN 0.6 9.45 0.46 6.65e-19 Intelligence (multi-trait analysis); CRC cis rs853679 0.585 rs201000 chr6:27809159 C/T cg20933634 chr6:27740509 NA 0.58 6.81 0.35 4.67e-11 Depression; CRC cis rs4072980 0.545 rs16824518 chr1:38415315 A/C cg04673462 chr1:38461896 NA -0.38 -6.13 -0.32 2.52e-9 Coronary artery disease; CRC cis rs12745968 0.620 rs7514156 chr1:92970209 A/G cg17283838 chr1:93427260 FAM69A -0.44 -6.24 -0.33 1.32e-9 Bipolar disorder and schizophrenia; CRC cis rs2239547 0.603 rs6789219 chr3:53098938 C/G cg18404041 chr3:52824283 ITIH1 -0.35 -6.17 -0.32 2.01e-9 Schizophrenia; CRC cis rs9649213 0.593 rs10953257 chr7:97960664 A/G cg24562669 chr7:97807699 LMTK2 -0.43 -7.14 -0.37 6.11e-12 Prostate cancer (SNP x SNP interaction); CRC cis rs875971 0.522 rs781144 chr7:65440344 C/G cg00343986 chr7:65444356 GUSB 0.54 8.18 0.41 6.38e-15 Aortic root size; CRC trans rs3010562 1.000 rs3010562 chr6:167765251 A/G cg13679164 chr6:161258479 NA -0.42 -6.58 -0.34 1.88e-10 Gut microbiome composition (summer and winter); CRC cis rs4862750 0.881 rs6813866 chr4:187872161 T/G cg03647317 chr4:187891568 NA -0.54 -9.78 -0.47 5.18e-20 Lobe attachment (rater-scored or self-reported); CRC cis rs7149337 0.836 rs12588488 chr14:51660217 C/A cg03361068 chr14:51561562 TRIM9 0.28 5.88 0.31 9.87e-9 Cancer; CRC cis rs17767392 0.918 rs2108707 chr14:71791170 G/C cg13720639 chr14:72061746 SIPA1L1 -0.54 -6.83 -0.35 4.17e-11 Mitral valve prolapse; CRC trans rs2012709 0.934 rs35508346 chr5:32577772 C/T cg03755955 chr8:6424269 MCPH1 0.4 6.0 0.31 5.3300000000000004e-09 Breast cancer; CRC cis rs7618915 0.547 rs11130311 chr3:52675005 T/C cg08222913 chr3:52553049 STAB1 -0.34 -6.14 -0.32 2.4e-9 Bipolar disorder; CRC cis rs17234274 0.607 rs10833975 chr11:23221973 T/C cg05245346 chr11:23248277 NA 0.36 5.85 0.31 1.22e-8 Cancer; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg11027325 chr2:239148674 HES6 0.38 6.23 0.32 1.42e-9 Liver disease severity in Alagille syndrome; CRC cis rs245880 0.740 rs245885 chr7:29188554 A/G cg17163760 chr7:29186267 CPVL -0.38 -6.66 -0.34 1.17e-10 Warfarin maintenance dose; CRC cis rs2070488 0.736 rs2070988 chr3:38437835 C/T cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.56 8.52 0.43 5.85e-16 Electrocardiographic conduction measures; CRC cis rs6141769 0.542 rs28548540 chr20:31294655 A/G cg13636640 chr20:31349939 DNMT3B -0.4 -6.12 -0.32 2.61e-9 Subjective well-being; CRC cis rs2336384 1.000 rs2103876 chr1:12053100 C/T cg13216073 chr1:12042593 MFN2 0.49 7.22 0.37 3.74e-12 Platelet count; CRC cis rs9787249 0.957 rs7548120 chr1:40204424 A/T cg01941586 chr1:40203715 PPIE -0.46 -6.34 -0.33 7.56e-10 Blood protein levels; CRC cis rs1005277 0.540 rs1987431 chr10:37988887 T/C cg25427524 chr10:38739819 LOC399744 -0.75 -12.99 -0.58 1.92e-31 Extrinsic epigenetic age acceleration; CRC cis rs6691722 0.506 rs1016209 chr1:24745615 A/G cg02336364 chr1:24764700 NIPAL3 -0.46 -8.17 -0.41 6.63e-15 Response to interferon beta in multiple sclerosis; CRC cis rs12898370 0.561 rs8028830 chr15:77508046 A/G cg05673287 chr15:77411982 SGK269 -0.5 -5.61 -0.3 4.33e-8 Risky sexual behaviors (alcohol dependence interaction); CRC cis rs7618915 0.501 rs13085775 chr3:52678370 C/T cg05573699 chr3:52720067 GNL3;PBRM1 -0.48 -7.03 -0.36 1.23e-11 Bipolar disorder; CRC cis rs1670533 1.000 rs633556 chr4:1092405 A/G cg27284194 chr4:1044797 NA 0.46 6.1 0.32 3.06e-9 Recombination rate (females); CRC cis rs476633 0.573 rs2099652 chr15:41528745 C/G cg18705301 chr15:41695430 NDUFAF1 -0.53 -8.79 -0.44 8.55e-17 Glomerular filtration rate (creatinine); CRC cis rs875971 0.929 rs778712 chr7:65849978 C/T cg11764359 chr7:65958608 NA 0.61 9.95 0.48 1.41e-20 Aortic root size; CRC cis rs892961 0.932 rs8066646 chr17:75414192 C/T cg05865280 chr17:75406074 SEPT9 0.62 14.27 0.62 2.79e-36 Airflow obstruction; CRC trans rs75804782 0.641 rs11904390 chr2:239344663 T/A cg01134436 chr17:81009848 B3GNTL1 0.74 6.97 0.36 1.7e-11 Morning vs. evening chronotype;Chronotype; CRC cis rs1403694 0.695 rs67173199 chr3:186432858 G/A cg04611788 chr3:186434169 KNG1 -0.6 -8.83 -0.44 6.23e-17 Blood protein levels; CRC cis rs7904985 1.000 rs7084928 chr10:88122516 C/T cg07322936 chr10:88137208 NA -0.45 -6.11 -0.32 2.83e-9 Barrett's esophagus; CRC cis rs2425143 1.000 rs4602287 chr20:34368028 C/G cg04508476 chr20:34239394 CPNE1;RBM12 0.48 6.08 0.32 3.36e-9 Blood protein levels; CRC cis rs7224737 1.000 rs8070446 chr17:40285879 G/A cg00647820 chr17:40259828 DHX58 -0.46 -6.59 -0.34 1.78e-10 Fibrinogen levels; CRC cis rs9811920 0.599 rs61148087 chr3:99539891 C/A cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G -0.45 -5.98 -0.31 5.88e-9 Axial length; CRC cis rs1799949 0.965 rs8176161 chr17:41241390 C/A cg05368731 chr17:41323189 NBR1 0.69 10.36 0.5 5.83e-22 Menopause (age at onset); CRC cis rs873946 0.586 rs12776770 chr10:134564831 T/C cg27286337 chr10:134555280 INPP5A 0.68 8.53 0.43 5.4e-16 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CRC cis rs2032447 0.610 rs189911 chr6:25965942 A/G cg26028573 chr6:26043587 HIST1H2BB 0.45 6.47 0.34 3.53e-10 Intelligence (multi-trait analysis); CRC cis rs4700695 0.925 rs796728 chr5:65382500 C/T cg21114390 chr5:65439923 SFRS12 -0.54 -6.76 -0.35 6.32e-11 Facial morphology (factor 19); CRC trans rs9393777 0.778 rs4452638 chr6:27229265 A/G cg06606381 chr12:133084897 FBRSL1 0.82 6.32 0.33 8.52e-10 Intelligence (multi-trait analysis); CRC cis rs7953249 0.564 rs11065385 chr12:121423386 A/G cg02403541 chr12:121454288 C12orf43 -0.39 -5.73 -0.3 2.3e-8 Invasive epithelial ovarian cancer;High-grade serous ovarian cancer;Chronic obstructive pulmonary disease-related biomarkers;N-glycan levels;Serous invasive ovarian cancer;Epithelial ovarian cancer; CRC cis rs12936587 0.601 rs7212538 chr17:17554587 T/G cg04398451 chr17:18023971 MYO15A 0.36 6.0 0.31 5.2e-9 Hip circumference;Coronary artery disease or large artery stroke;Coronary heart disease;Coronary artery disease; CRC cis rs72717009 0.825 rs10494360 chr1:161475750 G/A cg10431340 chr1:161279108 MPZ -0.56 -7.42 -0.38 1.04e-12 Rheumatoid arthritis; CRC cis rs4803468 1.000 rs284658 chr19:41929988 G/A cg09537434 chr19:41945824 ATP5SL -0.92 -17.96 -0.7 9.13e-51 Height; CRC cis rs9467711 0.606 rs9358938 chr6:26387546 C/T cg16898833 chr6:26189333 HIST1H4D 1.0 8.11 0.41 1.03e-14 Autism spectrum disorder or schizophrenia; CRC cis rs7412746 0.611 rs10888398 chr1:150886782 A/G cg10589385 chr1:150898437 SETDB1 -0.27 -5.88 -0.31 9.98e-9 Melanoma; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg07236925 chr15:91498269 RCCD1 0.45 6.4 0.33 5.44e-10 Response to antipsychotic treatment; CRC cis rs60843830 0.964 rs62114538 chr2:256116 G/T cg25945732 chr2:264204 ACP1;SH3YL1 0.71 11.83 0.55 3.87e-27 Spherical equivalent (joint analysis main effects and education interaction); CRC cis rs6662572 0.737 rs7530480 chr1:46399655 T/C cg03123370 chr1:45965343 CCDC163P;MMACHC -0.45 -5.76 -0.3 1.98e-8 Blood protein levels; CRC cis rs753778 0.570 rs10875465 chr8:142210500 A/G cg18755752 chr8:142205143 DENND3 -0.61 -10.5 -0.5 1.9e-22 Reticulocyte fraction of red cells;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; CRC cis rs853679 0.517 rs35227624 chr6:28132726 A/G cg25164649 chr6:28176230 NA 0.78 9.66 0.47 1.33e-19 Depression; CRC cis rs28386778 0.799 rs12450683 chr17:61984299 C/G cg25654072 chr17:61904446 PSMC5;FTSJ3 0.56 8.79 0.44 8.38e-17 Prudent dietary pattern; CRC cis rs72781680 0.898 rs72786298 chr2:24083011 C/T cg08917208 chr2:24149416 ATAD2B 1.02 9.93 0.48 1.65e-20 Lymphocyte counts; CRC cis rs76878669 0.561 rs4930362 chr11:66154360 T/C cg18002602 chr11:66138449 SLC29A2 0.27 5.85 0.31 1.22e-8 Educational attainment (years of education); CRC cis rs798554 0.757 rs1182178 chr7:2873763 G/A cg04166393 chr7:2884313 GNA12 0.5 6.75 0.35 6.54e-11 Height; CRC cis rs9322193 0.884 rs7769115 chr6:150169932 C/T cg07701084 chr6:150067640 NUP43 0.49 6.79 0.35 5.34e-11 Lung cancer; CRC cis rs13064447 0.874 rs13058951 chr3:12752381 C/T cg07775309 chr3:12595852 NA -0.35 -5.78 -0.3 1.78e-8 Major depression and alcohol dependence; CRC cis rs7208859 0.562 rs8078897 chr17:29106257 T/G cg13385521 chr17:29058706 SUZ12P 0.73 8.33 0.42 2.14e-15 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs727505 0.954 rs28728448 chr7:124532938 T/A cg23710748 chr7:124431027 NA -0.79 -14.17 -0.62 6.42e-36 Lewy body disease; CRC cis rs4073416 0.542 rs2411820 chr14:65946744 C/T cg03016385 chr14:66212404 NA -0.43 -5.93 -0.31 7.47e-9 N-glycan levels; CRC cis rs7107174 1.000 rs2512541 chr11:77981747 A/T cg02023728 chr11:77925099 USP35 0.54 8.28 0.42 3.21e-15 Testicular germ cell tumor; CRC cis rs3091242 0.933 rs9438905 chr1:25764177 A/G cg23205692 chr1:25664452 TMEM50A 0.42 5.91 0.31 8.46e-9 Erythrocyte sedimentation rate; CRC cis rs2303759 0.709 rs10414921 chr19:49823047 C/T cg22590775 chr19:49891494 CCDC155 0.6 7.9 0.4 4.3e-14 Multiple sclerosis; CRC cis rs9916302 0.680 rs2271308 chr17:37817482 T/C cg07936489 chr17:37558343 FBXL20 -0.54 -8.08 -0.41 1.26e-14 Glomerular filtration rate (creatinine); CRC cis rs6500395 0.890 rs9936445 chr16:48617754 T/G cg04672837 chr16:48644449 N4BP1 0.42 6.04 0.32 4.1e-9 Response to tocilizumab in rheumatoid arthritis; CRC cis rs10504229 0.595 rs36081958 chr8:58117505 C/G cg24829409 chr8:58192753 C8orf71 -0.54 -7.82 -0.4 7.48e-14 Developmental language disorder (linguistic errors); CRC cis rs6502050 0.799 rs6502088 chr17:80169484 C/T cg22110888 chr17:80059540 CCDC57 0.4 6.24 0.33 1.33e-9 Life satisfaction; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg08181479 chr10:81838760 LOC219347;C10orf57 -0.46 -6.84 -0.35 3.87e-11 Myopia (pathological); CRC cis rs7223966 1.000 rs6504168 chr17:61697469 G/T cg23090583 chr17:61904693 PSMC5;FTSJ3 0.51 6.24 0.33 1.34e-9 Hip circumference adjusted for BMI;Body mass index; CRC cis rs60871478 0.679 rs62432240 chr7:794813 A/G cg13844804 chr7:814759 HEATR2 0.68 7.43 0.38 9.18e-13 Cerebrospinal P-tau181p levels; CRC cis rs853679 0.517 rs4713146 chr6:28111536 A/T cg12273811 chr6:28175739 NA 0.73 9.16 0.45 5.8e-18 Depression; CRC cis rs6964587 0.900 rs7783674 chr7:91784212 T/A cg17063962 chr7:91808500 NA 0.85 15.11 0.64 1.46e-39 Breast cancer; CRC cis rs9733 0.543 rs72702558 chr1:150683251 G/A cg17724175 chr1:150552817 MCL1 0.57 9.12 0.45 7.76e-18 Tonsillectomy; CRC cis rs4716602 0.596 rs10265482 chr7:156160655 C/G cg16983916 chr7:156159713 NA -0.39 -6.88 -0.35 3.1e-11 Anti-saccade response; CRC cis rs12980942 0.591 rs4591267 chr19:41765407 A/C cg25627403 chr19:41769009 HNRNPUL1 0.56 6.39 0.33 5.58e-10 Coronary artery disease; CRC cis rs9457247 0.935 rs401260 chr6:167405888 T/C cg23791538 chr6:167370224 RNASET2 -0.38 -5.94 -0.31 7.32e-9 Crohn's disease; CRC cis rs9814567 1.000 rs13322305 chr3:134310791 G/A cg06109529 chr3:134205091 CEP63;ANAPC13 -0.8 -11.7 -0.54 1.13e-26 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC trans rs9858542 1.000 rs11130213 chr3:49712297 C/T cg21659725 chr3:3221576 CRBN -0.68 -8.92 -0.44 3.4e-17 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs9814567 0.752 rs6779294 chr3:134329821 G/A cg06109529 chr3:134205091 CEP63;ANAPC13 -0.67 -9.58 -0.47 2.53e-19 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs6860806 0.661 rs2136187 chr5:131577894 T/C cg12564285 chr5:131593104 PDLIM4 0.5 9.73 0.47 7.8500000000000006e-20 Breast cancer; CRC cis rs9311474 0.629 rs4282054 chr3:52566065 T/C cg17372223 chr3:52568218 NT5DC2 0.4 6.15 0.32 2.21e-9 Electroencephalogram traits; CRC trans rs17685 0.712 rs60721456 chr7:75743820 T/A cg19862616 chr7:65841803 NCRNA00174 0.97 17.9 0.7 1.69e-50 Coffee consumption;Coffee consumption (cups per day); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg03064167 chr17:38279234 MSL1 0.44 6.07 0.32 3.58e-9 Response to antipsychotic treatment; CRC cis rs4964805 1.000 rs1866295 chr12:104186946 G/T cg02344784 chr12:104178138 NT5DC3 0.57 8.68 0.43 1.86e-16 Attention deficit hyperactivity disorder; CRC cis rs2346177 0.875 rs6726089 chr2:46645480 T/C cg26688816 chr2:46740690 ATP6V1E2 -0.48 -7.67 -0.39 1.92e-13 HDL cholesterol; CRC cis rs9910055 0.762 rs2240226 chr17:42266218 C/T cg19774624 chr17:42201019 HDAC5 -0.67 -9.91 -0.48 2.02e-20 Total body bone mineral density; CRC cis rs11628318 0.614 rs72635192 chr14:103128646 C/T cg12046867 chr14:103022105 NA 0.76 8.98 0.44 2.2e-17 Platelet count; CRC cis rs7772486 0.536 rs9373467 chr6:145955605 C/T cg23711669 chr6:146136114 FBXO30 0.61 8.73 0.43 1.33e-16 Lobe attachment (rater-scored or self-reported); CRC cis rs4862750 0.872 rs7672831 chr4:187898882 C/T cg07414643 chr4:187882934 NA 0.4 7.23 0.37 3.42e-12 Lobe attachment (rater-scored or self-reported); CRC cis rs6701037 0.566 rs1014555 chr1:175134249 C/T cg14847009 chr1:175162515 KIAA0040 0.3 6.66 0.34 1.18e-10 Alcohol dependence; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg06216926 chr14:92572917 ATXN3 0.5 7.09 0.36 8.37e-12 Response to antipsychotic treatment; CRC cis rs10504229 0.683 rs7817188 chr8:58129549 C/T cg24829409 chr8:58192753 C8orf71 -0.55 -8.03 -0.4 1.71e-14 Developmental language disorder (linguistic errors); CRC cis rs1055129 0.537 rs10852766 chr17:73951864 T/C cg08125733 chr17:73851984 WBP2 -0.47 -6.27 -0.33 1.1e-9 White matter hyperintensity burden; CRC cis rs17433780 0.860 rs61798916 chr1:89493957 G/A cg09516651 chr1:89888402 LOC400759 0.48 7.29 0.37 2.38e-12 Carotid intima media thickness; CRC cis rs798554 0.704 rs798513 chr7:2782493 C/T cg17321639 chr7:2759063 NA -0.37 -5.65 -0.3 3.54e-8 Height; CRC cis rs4481887 0.927 rs4350233 chr1:248489994 G/A cg00666640 chr1:248458726 OR2T12 0.49 8.29 0.42 3.01e-15 Common traits (Other); CRC cis rs2289328 0.825 rs35777573 chr15:40644246 T/A cg13931752 chr15:40660718 DISP2 0.57 5.79 0.3 1.66e-8 Intelligence (multi-trait analysis);Cognitive ability;Cognitive ability (multi-trait analysis); CRC cis rs3785574 0.962 rs2727331 chr17:61926990 G/T cg11494091 chr17:61959527 GH2 0.37 5.64 0.3 3.7e-8 Height; CRC cis rs7811142 1.000 rs112317829 chr7:100043173 A/G cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.75 10.81 0.51 1.64e-23 Platelet count; CRC cis rs6502050 0.835 rs9674648 chr17:80096756 A/G cg02741985 chr17:80059408 CCDC57 0.43 7.24 0.37 3.25e-12 Life satisfaction; CRC cis rs10504229 0.683 rs56408763 chr8:58137276 G/A cg02725872 chr8:58115012 NA -0.64 -11.55 -0.54 3.85e-26 Developmental language disorder (linguistic errors); CRC cis rs12024301 0.557 rs78714242 chr1:183609310 T/C cg11505048 chr1:183622726 RGL1;APOBEC4 0.81 6.83 0.35 4.19e-11 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs1964356 0.967 rs17701675 chr8:8850633 A/G cg08975724 chr8:8085496 FLJ10661 -0.38 -5.83 -0.31 1.32e-8 Mean corpuscular volume; CRC cis rs2732480 0.500 rs7297824 chr12:48598650 T/C cg24011408 chr12:48396354 COL2A1 0.43 6.18 0.32 1.87e-9 Hemoglobin concentration;Red blood cell count;Hematocrit; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg16040186 chr17:57298050 GDPD1 0.42 6.11 0.32 2.85e-9 Intelligence (multi-trait analysis); CRC cis rs11123170 0.650 rs2289897 chr2:113977454 G/A cg12889195 chr2:113992843 PAX8;LOC440839;LOC654433 0.6 7.34 0.38 1.69e-12 Renal function-related traits (BUN); CRC cis rs1552244 1.000 rs35993975 chr3:10067794 A/G cg00166722 chr3:10149974 C3orf24 0.7 8.33 0.42 2.21e-15 Alzheimer's disease; CRC cis rs13108904 0.967 rs11247986 chr4:1294347 G/A cg02018176 chr4:1364513 KIAA1530 0.48 7.72 0.39 1.37e-13 Obesity-related traits; CRC cis rs6534441 0.727 rs6848373 chr4:125426113 T/C cg21609808 chr4:125404261 NA 0.39 5.64 0.3 3.67e-8 Major depressive disorder; CRC cis rs9611565 0.921 rs2281332 chr22:41746212 T/C cg03806693 chr22:41940476 POLR3H -0.66 -9.63 -0.47 1.63e-19 Vitiligo; CRC cis rs35146811 0.735 rs1727130 chr7:99811464 C/G cg00553149 chr7:99775558 STAG3;GPC2 -0.24 -5.61 -0.3 4.38e-8 Coronary artery disease; CRC cis rs1832871 0.655 rs4292552 chr6:158722888 G/A cg07165851 chr6:158734300 TULP4 0.62 7.81 0.4 7.93e-14 Height; CRC cis rs9467711 0.606 rs9358938 chr6:26387546 C/T cg12315302 chr6:26189340 HIST1H4D 0.89 6.86 0.35 3.44e-11 Autism spectrum disorder or schizophrenia; CRC cis rs932287 0.505 rs2742536 chr11:8909816 G/C cg12365402 chr11:9010492 NRIP3 -0.53 -9.43 -0.46 7.39e-19 Colonoscopy-negative controls vs population controls; CRC cis rs1552244 0.748 rs113890152 chr3:10085986 A/G cg13047869 chr3:10149882 C3orf24 0.58 7.77 0.39 9.84e-14 Alzheimer's disease; CRC cis rs7666738 0.830 rs11932942 chr4:98998939 T/C cg05340658 chr4:99064831 C4orf37 0.61 9.54 0.47 3.44e-19 Colonoscopy-negative controls vs population controls; CRC cis rs9303401 0.614 rs8081058 chr17:57160513 G/C cg10487724 chr17:56770010 TEX14;RAD51C 0.69 8.54 0.43 5.13e-16 Cognitive test performance; CRC cis rs4718428 0.705 rs10267335 chr7:66403220 G/T cg18252515 chr7:66147081 NA -0.55 -7.72 -0.39 1.42e-13 Corneal structure; CRC cis rs6456156 0.792 rs4710178 chr6:167513532 G/A cg07741184 chr6:167504864 NA 0.49 8.48 0.42 7.95e-16 Primary biliary cholangitis; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg13495574 chr1:173793781 CENPL;DARS2 0.44 7.28 0.37 2.51e-12 Liver disease severity in Alagille syndrome; CRC cis rs9611519 0.780 rs2235852 chr22:41661154 G/T cg03806693 chr22:41940476 POLR3H -0.61 -7.99 -0.4 2.32e-14 Neuroticism; CRC cis rs9322193 0.961 rs2064520 chr6:149924786 A/T cg13206674 chr6:150067644 NUP43 0.63 9.29 0.46 2.1e-18 Lung cancer; CRC cis rs910187 0.537 rs6122556 chr20:45763924 T/A cg27589058 chr20:45804311 EYA2 -0.35 -6.15 -0.32 2.2e-9 Migraine; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg02628353 chr7:26241504 HNRNPA2B1;CBX3 0.44 6.17 0.32 1.98e-9 Response to antipsychotic treatment; CRC cis rs8180040 0.966 rs6800271 chr3:47470787 A/T cg02527881 chr3:46936655 PTH1R 0.39 7.29 0.37 2.39e-12 Colorectal cancer; CRC cis rs79057730 0.599 rs9458 chr7:825494 A/G cg05729249 chr7:766119 PRKAR1B;HEATR2 -0.65 -7.15 -0.37 5.49e-12 Initial pursuit acceleration; CRC trans rs9329221 0.662 rs11249996 chr8:10245463 G/T cg06636001 chr8:8085503 FLJ10661 -0.48 -7.28 -0.37 2.42e-12 Neuroticism; CRC cis rs870825 0.616 rs72705689 chr4:185639894 A/G cg04058563 chr4:185651563 MLF1IP 0.73 9.7 0.47 9.94e-20 Blood protein levels; CRC cis rs17270561 0.609 rs4712964 chr6:25740822 A/T cg17691542 chr6:26056736 HIST1H1C 0.73 9.29 0.46 2.18e-18 Iron status biomarkers; CRC trans rs2014572 0.870 rs10426580 chr19:57756221 G/A cg02674126 chr19:40336878 FBL 0.43 6.91 0.36 2.58e-11 Hyperactive-impulsive symptoms; CRC cis rs6582630 0.555 rs2387598 chr12:38510472 G/A cg13010199 chr12:38710504 ALG10B -0.47 -6.85 -0.35 3.65e-11 Drug-induced liver injury (flucloxacillin); CRC cis rs611744 0.647 rs4735053 chr8:109260776 A/G cg18478394 chr8:109455254 TTC35 0.37 5.71 0.3 2.5e-8 Dupuytren's disease; CRC cis rs9487051 0.737 rs1260593 chr6:109521400 C/T cg01475377 chr6:109611718 NA -0.34 -5.86 -0.31 1.15e-8 Reticulocyte fraction of red cells; CRC trans rs10982213 0.830 rs2274163 chr9:117188714 C/T cg15947007 chr7:64023509 ZNF680 0.42 6.44 0.33 4.12e-10 Interleukin-6 levels; CRC cis rs4073416 0.542 rs7144971 chr14:66120650 A/G cg03016385 chr14:66212404 NA 0.4 5.63 0.3 3.85e-8 N-glycan levels; CRC cis rs875971 1.000 rs778722 chr7:65844828 T/C cg18876405 chr7:65276391 NA 0.52 9.04 0.45 1.37e-17 Aortic root size; CRC cis rs9488822 0.702 rs12196154 chr6:116327471 T/G cg15226275 chr6:116381976 FRK 0.3 8.5 0.42 6.55e-16 Cholesterol, total;LDL cholesterol; CRC cis rs62064224 0.554 rs9894877 chr17:30679517 T/A cg25809561 chr17:30822961 MYO1D 0.53 9.21 0.45 3.82e-18 Schizophrenia; CRC cis rs1577917 0.958 rs10944168 chr6:86680156 C/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.52 -6.5 -0.34 2.98e-10 Response to antipsychotic treatment; CRC cis rs4711336 1.000 rs4711337 chr6:33659987 T/C cg14003231 chr6:33640908 ITPR3 0.46 7.36 0.38 1.5e-12 Height; CRC cis rs62458065 0.850 rs10273165 chr7:32460840 G/A cg20159608 chr7:32802032 NA -0.54 -6.64 -0.34 1.26e-10 Metabolite levels (HVA/MHPG ratio); CRC cis rs6479527 0.840 rs1854835 chr9:96768337 A/G cg14459158 chr9:96720562 NA 0.39 7.02 0.36 1.24e-11 Esophageal adenocarcinoma; CRC cis rs9649213 0.574 rs60077733 chr7:97970137 C/T cg00277769 chr7:97922759 BAIAP2L1 -0.57 -9.63 -0.47 1.69e-19 Prostate cancer (SNP x SNP interaction); CRC cis rs7727544 0.716 rs72793283 chr5:131566941 G/A cg04518342 chr5:131593106 PDLIM4 0.38 6.9 0.36 2.73e-11 Blood metabolite levels; CRC cis rs10504073 0.647 rs11997959 chr8:50014044 C/T cg00325661 chr8:49890786 NA 0.47 8.43 0.42 1.08e-15 Blood metabolite ratios; CRC cis rs4731207 0.564 rs10954060 chr7:124626037 G/A cg23710748 chr7:124431027 NA -0.39 -6.25 -0.33 1.29e-9 Cutaneous malignant melanoma; CRC trans rs3733585 0.699 rs13328050 chr4:9951120 G/T cg26043149 chr18:55253948 FECH -0.48 -7.33 -0.37 1.83e-12 Cleft plate (environmental tobacco smoke interaction); CRC cis rs1832871 0.672 rs11751553 chr6:158774750 C/T cg07165851 chr6:158734300 TULP4 -0.59 -7.59 -0.39 3.38e-13 Height; CRC cis rs10504229 0.683 rs17194529 chr8:58105647 A/G cg24829409 chr8:58192753 C8orf71 -0.63 -7.78 -0.39 9.36e-14 Developmental language disorder (linguistic errors); CRC cis rs2425143 0.908 rs6060632 chr20:34422601 G/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.53 -5.97 -0.31 6.04e-9 Blood protein levels; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg12232852 chr3:69129018 UBA3 0.47 6.18 0.32 1.89e-9 Anxiety disorder; CRC cis rs3018066 0.867 rs28467469 chr4:107036627 T/C cg01869342 chr4:106983673 TBCK 0.36 5.66 0.3 3.26e-8 Cancer; CRC trans rs1997103 0.954 rs940880 chr7:55392619 C/G cg20935933 chr6:143382018 AIG1 0.53 6.72 0.35 7.86e-11 QRS interval (sulfonylurea treatment interaction); CRC cis rs9902453 0.967 rs56129908 chr17:28421382 T/A cg26525008 chr17:28256777 EFCAB5;SSH2 0.59 8.79 0.44 8.21e-17 Coffee consumption (cups per day); CRC cis rs9527 0.590 rs7920868 chr10:104795409 C/T cg15744005 chr10:104629667 AS3MT -0.31 -6.21 -0.32 1.59e-9 Arsenic metabolism; CRC cis rs138857 0.515 rs9616373 chr22:50308597 G/A cg02269571 chr22:50332266 NA -0.82 -8.7 -0.43 1.66e-16 Mean platelet volume; CRC cis rs7113874 0.531 rs7934396 chr11:8615632 C/G cg17679104 chr11:8615758 STK33 0.38 6.4 0.33 5.31e-10 Body mass index in physically active individuals;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs427943 0.750 rs8126726 chr21:46609115 A/T cg19498844 chr21:46707878 POFUT2;LOC642852 0.45 5.92 0.31 7.91e-9 Body mass index; CRC cis rs801193 0.844 rs732465 chr7:65998450 T/C cg00343986 chr7:65444356 GUSB 0.47 7.04 0.36 1.15e-11 Aortic root size; CRC cis rs78456975 0.527 rs10203194 chr2:1558021 A/G cg12573674 chr2:1569213 NA -0.82 -10.55 -0.5 1.33e-22 Placebo response in major depressive disorder (% change in symptom score); CRC trans rs61931739 0.500 rs7489130 chr12:34539674 C/A cg26384229 chr12:38710491 ALG10B 0.68 8.8 0.44 7.69e-17 Morning vs. evening chronotype; CRC trans rs76662990 0.665 rs7356676 chr5:73917301 A/G cg04396288 chr16:27279887 NSMCE1 0.59 5.96 0.31 6.45e-9 Residual cognition; CRC cis rs4481887 0.800 rs10888342 chr1:248441999 A/G cg00666640 chr1:248458726 OR2T12 0.48 8.36 0.42 1.85e-15 Common traits (Other); CRC cis rs736408 0.609 rs13087772 chr3:52782274 T/G cg05573699 chr3:52720067 GNL3;PBRM1 -0.44 -6.13 -0.32 2.54e-9 Bipolar disorder; CRC cis rs10638925 1 rs10638925 chr3:194119749 C/CCATAAA cg22961107 chr3:194096808 NA 0.3 6.2 0.32 1.73e-9 Platelet distribution width; CRC cis rs853679 0.542 rs9380063 chr6:28137853 A/G cg25164649 chr6:28176230 NA 0.78 9.66 0.47 1.33e-19 Depression; CRC cis rs10788264 0.544 rs10788269 chr10:124022870 A/G cg05683857 chr10:124030795 BTBD16 0.32 5.82 0.31 1.39e-8 Total body bone mineral density; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg18387085 chr18:72922610 ZADH2;TSHZ1 0.41 6.17 0.32 1.99e-9 Liver disease severity in Alagille syndrome; CRC trans rs7395662 0.818 rs2200181 chr11:48413175 C/G cg21153622 chr11:89784906 NA -0.46 -7.23 -0.37 3.45e-12 HDL cholesterol; CRC cis rs4604732 0.588 rs7549495 chr1:247627806 G/A cg02104434 chr1:247694406 LOC148824;OR2C3 0.54 8.15 0.41 7.85e-15 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CRC cis rs2228479 0.702 rs17226841 chr16:89828484 C/T cg19635926 chr16:89946313 TCF25 0.63 5.68 0.3 3.01e-8 Skin colour saturation; CRC trans rs9858542 0.953 rs11926781 chr3:49603289 C/T cg21582582 chr3:182698605 DCUN1D1 -0.53 -6.48 -0.34 3.42e-10 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs853679 0.517 rs9468298 chr6:28122345 A/G cg03623178 chr6:28175578 NA 0.98 12.66 0.57 3.31e-30 Depression; CRC cis rs7824557 0.872 rs2572417 chr8:11111462 A/T cg20542592 chr8:11973495 FAM66D 0.33 5.72 0.3 2.34e-8 Retinal vascular caliber; CRC cis rs2075371 0.933 rs1833475 chr7:133958263 C/T cg20476274 chr7:133979776 SLC35B4 0.78 14.1 0.61 1.18e-35 Mean platelet volume; CRC cis rs12497850 0.931 rs28642807 chr3:48926816 A/G cg20833759 chr3:49053208 WDR6;DALRD3 0.53 9.18 0.45 4.89e-18 Parkinson's disease; CRC cis rs6762477 0.748 rs11717349 chr3:50223977 C/T cg24110177 chr3:50126178 RBM5 0.43 6.52 0.34 2.58e-10 Menarche (age at onset); CRC cis rs7223966 1.000 rs13380863 chr17:61780793 G/A cg05941027 chr17:61774174 LIMD2 0.36 6.25 0.33 1.24e-9 Hip circumference adjusted for BMI;Body mass index; CRC cis rs2276314 0.857 rs28435069 chr18:33628475 A/G cg19628046 chr18:33552617 C18orf21 0.56 7.85 0.4 6.06e-14 Endometriosis;Drug-induced torsades de pointes; CRC cis rs2411233 1.000 rs11635288 chr15:39270328 G/C cg23129342 chr15:39283510 NA 0.31 5.64 0.3 3.69e-8 Platelet count; CRC trans rs7267979 1.000 rs3761117 chr20:25388070 G/A cg17903999 chr18:56338584 MALT1 0.41 6.9 0.36 2.61e-11 Liver enzyme levels (alkaline phosphatase); CRC cis rs9527 0.622 rs12779263 chr10:104886533 G/T cg04362960 chr10:104952993 NT5C2 0.64 8.75 0.43 1.12e-16 Arsenic metabolism; CRC cis rs7208859 0.673 rs2470251 chr17:29095061 T/C cg14008862 chr17:28927542 LRRC37B2 0.5 5.76 0.3 1.98e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs889312 0.500 rs865570 chr5:56161975 C/T cg24531977 chr5:56204891 C5orf35 -0.44 -6.65 -0.34 1.26e-10 Breast cancer;Breast cancer (early onset); CRC cis rs1223397 0.938 rs35549743 chr6:13294354 C/T cg06879394 chr6:13274151 PHACTR1 0.53 6.18 0.32 1.87e-9 Blood pressure; CRC cis rs55794721 0.509 rs2982358 chr1:25745204 G/T cg23205692 chr1:25664452 TMEM50A 0.43 6.21 0.32 1.57e-9 Plateletcrit;Mean corpuscular volume; CRC cis rs7633770 0.786 rs9845998 chr3:46683710 G/A cg11219411 chr3:46661640 NA 0.54 8.61 0.43 3.01e-16 Coronary artery disease; CRC cis rs12142240 0.698 rs67276232 chr1:46825484 T/G cg14993813 chr1:46806288 NSUN4 -0.49 -6.22 -0.32 1.55e-9 Menopause (age at onset); CRC cis rs9398803 0.865 rs4897181 chr6:126753564 C/T cg19875578 chr6:126661172 C6orf173 0.42 5.99 0.31 5.54e-9 Male-pattern baldness; CRC cis rs523522 0.962 rs12309824 chr12:120990582 A/C cg12219531 chr12:120966889 COQ5 0.7 9.22 0.45 3.67e-18 High light scatter reticulocyte count; CRC cis rs9420 0.961 rs77993055 chr11:57522840 C/T cg23127183 chr11:57508653 C11orf31 -0.53 -7.08 -0.36 8.9e-12 Schizophrenia; CRC cis rs7618915 0.547 rs12496634 chr3:52709259 A/C cg07507251 chr3:52567010 NT5DC2 0.42 6.06 0.32 3.7e-9 Bipolar disorder; CRC cis rs10256972 0.678 rs6962989 chr7:1017512 G/A cg26224354 chr7:1096374 C7orf50;GPR146 -0.62 -6.67 -0.35 1.05e-10 Longevity;Endometriosis; CRC cis rs2565722 0.622 rs1937480 chr6:161304323 C/T cg03159191 chr6:161285451 NA -0.45 -6.22 -0.32 1.48e-9 Blood protein levels; CRC cis rs6598955 0.671 rs12086573 chr1:26574330 G/A cg04990556 chr1:26633338 UBXN11 0.56 6.02 0.32 4.53e-9 Obesity-related traits; CRC cis rs2953174 0.507 rs34568097 chr2:241540989 A/G cg07929629 chr2:241523174 NA 0.63 8.35 0.42 1.87e-15 Bipolar disorder; CRC cis rs834811 0.796 rs2349456 chr7:135901545 G/T cg01726295 chr7:135938950 NA -0.47 -8.39 -0.42 1.5e-15 Post-traumatic stress disorder; CRC cis rs11148252 0.875 rs9596651 chr13:52938582 A/G cg12458913 chr13:53173898 NA -0.51 -8.12 -0.41 9.43e-15 Lewy body disease; CRC cis rs172166 0.561 rs149974 chr6:27985096 T/C cg15845792 chr6:28175446 NA 0.63 9.46 0.46 6.31e-19 Cardiac Troponin-T levels; CRC cis rs8060686 0.920 rs112894876 chr16:67812039 G/C cg04539111 chr16:67997858 SLC12A4 -0.51 -5.91 -0.31 8.72e-9 HDL cholesterol;Metabolic syndrome; CRC cis rs172166 0.694 rs1150666 chr6:28123928 T/C cg15845792 chr6:28175446 NA 0.82 12.18 0.56 1.94e-28 Cardiac Troponin-T levels; CRC cis rs6502050 0.835 rs3924781 chr17:80113130 T/C cg19223190 chr17:80058835 NA 0.43 6.72 0.35 8.23e-11 Life satisfaction; CRC cis rs769267 0.930 rs4808955 chr19:19552413 T/C cg03709012 chr19:19516395 GATAD2A 0.73 10.84 0.51 1.26e-23 Tonsillectomy; CRC trans rs8073060 0.504 rs225271 chr17:33969836 C/T cg19694781 chr19:47549865 TMEM160 -1.04 -14.64 -0.63 1.02e-37 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; CRC cis rs2949837 0.655 rs11977526 chr7:46008110 G/A cg04727332 chr7:45960243 IGFBP3 0.42 6.41 0.33 5.01e-10 Sitting height ratio; CRC cis rs4285028 0.898 rs12491991 chr3:121706021 A/C cg20356878 chr3:121714668 ILDR1 0.48 7.13 0.37 6.22e-12 Multiple sclerosis; CRC cis rs2404602 0.563 rs12914005 chr15:76765667 A/G cg22467129 chr15:76604101 ETFA -0.44 -7.55 -0.38 4.43e-13 Blood metabolite levels; CRC cis rs875971 1.000 rs7792762 chr7:66004138 T/C cg11764359 chr7:65958608 NA 0.61 9.48 0.46 5.4e-19 Aortic root size; CRC cis rs7208859 0.623 rs9912283 chr17:29110373 A/G cg01831904 chr17:28903510 LRRC37B2 -0.63 -6.45 -0.33 4.07e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs10883723 0.737 rs11191312 chr10:104278601 T/C cg22532475 chr10:104410764 TRIM8 -0.38 -6.77 -0.35 5.93e-11 Allergic disease (asthma, hay fever or eczema); CRC cis rs7811142 0.943 rs111493473 chr7:100049742 A/G cg00814883 chr7:100076585 TSC22D4 -0.72 -9.39 -0.46 1e-18 Platelet count; CRC cis rs1552244 0.882 rs13062917 chr3:10017032 T/A cg13047869 chr3:10149882 C3orf24 0.51 6.91 0.36 2.54e-11 Alzheimer's disease; CRC cis rs2535633 0.631 rs2581827 chr3:52966558 C/T cg15147215 chr3:52552868 STAB1 0.43 6.92 0.36 2.4e-11 Body mass index; CRC cis rs728616 0.558 rs61859215 chr10:82151148 G/A cg11900509 chr10:81946545 ANXA11 -0.56 -6.24 -0.33 1.32e-9 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs950776 0.518 rs12906846 chr15:78825295 G/A cg06917634 chr15:78832804 PSMA4 0.66 10.42 0.5 3.55e-22 Sudden cardiac arrest; CRC cis rs3996993 0.809 rs9474334 chr6:52733458 A/G cg20803780 chr6:52668592 GSTA1 -0.36 -6.83 -0.35 4.1e-11 Hemoglobin concentration; CRC cis rs748404 0.697 rs504417 chr15:43554226 A/G cg02155558 chr15:43621948 ADAL;LCMT2 0.43 6.44 0.33 4.12e-10 Lung cancer; CRC cis rs2281845 0.533 rs112365857 chr1:201097222 G/C cg01987224 chr1:201084466 NA 0.41 5.68 0.3 3.01e-8 Permanent tooth development; CRC cis rs6502050 0.698 rs36043222 chr17:80117822 G/T cg11859384 chr17:80120422 CCDC57 -0.37 -5.9 -0.31 8.99e-9 Life satisfaction; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg07077115 chr13:28024429 MTIF3 0.48 6.14 0.32 2.39e-9 Thyroid stimulating hormone; CRC cis rs4713118 0.824 rs742046 chr6:27739254 A/G cg21251018 chr6:28226885 NKAPL 0.42 6.02 0.32 4.53e-9 Parkinson's disease; CRC cis rs8078723 0.866 rs11078934 chr17:38189793 C/T cg17344932 chr17:38183730 MED24;SNORD124 -0.47 -7.25 -0.37 2.94e-12 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); CRC cis rs4713118 0.868 rs9468220 chr6:27732976 A/G cg25164649 chr6:28176230 NA -0.68 -7.65 -0.39 2.2e-13 Parkinson's disease; CRC cis rs1005277 0.563 rs2505215 chr10:38481273 A/G cg25517755 chr10:38738941 LOC399744 -0.44 -6.44 -0.33 4.31e-10 Extrinsic epigenetic age acceleration; CRC cis rs1552244 1.000 rs57631744 chr3:10118962 T/C cg08888203 chr3:10149979 C3orf24 0.7 10.07 0.49 5.94e-21 Alzheimer's disease; CRC cis rs992157 0.560 rs6738394 chr2:219110625 G/A cg00012203 chr2:219082015 ARPC2 -0.54 -8.54 -0.43 5.19e-16 Colorectal cancer; CRC trans rs11023787 1.000 rs10458876 chr11:15939080 A/G cg00338749 chr11:1036677 MUC6 -0.52 -5.97 -0.31 6.27e-9 Bone mineral density (wrist); CRC cis rs7811142 0.830 rs6965458 chr7:99973402 G/A cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.1 14.46 0.62 4.93e-37 Platelet count; CRC cis rs300703 0.542 rs376385 chr2:190245 G/A cg21211680 chr2:198530 NA 0.8 9.85 0.48 3.23e-20 Blood protein levels; CRC cis rs7258465 0.931 rs875396 chr19:18611147 A/G cg01065977 chr19:18549689 ISYNA1 -0.41 -6.41 -0.33 5.1e-10 Breast cancer; CRC cis rs747650 0.532 rs10838658 chr11:47130778 G/A cg19486271 chr11:47235900 DDB2 0.46 6.13 0.32 2.47e-9 Acne (severe); CRC cis rs9846480 0.598 rs7639850 chr3:138073564 G/A cg25476813 chr3:138050155 TXNDC6 -0.38 -5.63 -0.3 3.95e-8 Whole-brain volume (Alzheimer's disease interaction); CRC trans rs7267979 0.744 rs6050464 chr20:25209299 C/A cg17903999 chr18:56338584 MALT1 -0.38 -6.26 -0.33 1.18e-9 Liver enzyme levels (alkaline phosphatase); CRC cis rs711830 0.576 rs72916141 chr2:177069364 G/T cg13092806 chr2:177043255 NA -0.61 -6.93 -0.36 2.29e-11 Serous invasive ovarian cancer;Epithelial ovarian cancer;Invasive epithelial ovarian cancer;Mucinous ovarian carcinoma;Low-grade serous and serous borderline ovarian cancer;Serous borderline ovarian cancer;High-grade serous ovarian cancer; CRC cis rs7618915 0.547 rs2268027 chr3:52766606 G/A cg18099408 chr3:52552593 STAB1 -0.44 -7.2 -0.37 4.11e-12 Bipolar disorder; CRC cis rs9916302 0.706 rs11657153 chr17:37699729 A/G cg00129232 chr17:37814104 STARD3 -0.59 -7.28 -0.37 2.45e-12 Glomerular filtration rate (creatinine); CRC cis rs12477438 0.765 rs2167930 chr2:99592551 A/T cg14399236 chr2:99771627 LIPT1;TSGA10 -0.7 -9.74 -0.47 7.45e-20 Chronic sinus infection; CRC cis rs11711311 0.955 rs10934241 chr3:113394705 G/A cg15478005 chr3:113465772 ATP6V1A;NAA50 0.47 6.28 0.33 1.06e-9 IgG glycosylation; CRC cis rs7512552 0.809 rs698923 chr1:150379159 G/A cg15654264 chr1:150340011 RPRD2 0.6 8.46 0.42 9.15e-16 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); CRC cis rs4713118 0.868 rs35069907 chr6:27746692 T/C cg03623178 chr6:28175578 NA 0.71 7.89 0.4 4.45e-14 Parkinson's disease; CRC cis rs763121 0.853 rs4821811 chr22:39075145 C/T cg06022373 chr22:39101656 GTPBP1 0.79 12.33 0.56 5.61e-29 Menopause (age at onset); CRC cis rs7091068 0.671 rs1096025 chr10:95404701 T/C cg20715218 chr10:95462985 C10orf4 -0.48 -5.66 -0.3 3.38e-8 Urinary tract infection frequency; CRC cis rs7927592 0.956 rs60212556 chr11:68305494 C/T cg01657329 chr11:68192670 LRP5 -0.47 -6.79 -0.35 5.32e-11 Total body bone mineral density; CRC cis rs10751667 0.643 rs7394524 chr11:933865 T/C cg23136738 chr11:925521 AP2A2 -0.41 -6.78 -0.35 5.53e-11 Alzheimer's disease (late onset); CRC cis rs9325144 0.647 rs17518186 chr12:38883665 T/C cg26384229 chr12:38710491 ALG10B -0.51 -7.26 -0.37 2.76e-12 Morning vs. evening chronotype; CRC cis rs4692589 1.000 rs17546378 chr4:170935854 G/A cg19918862 chr4:170955249 NA 0.38 6.22 0.32 1.53e-9 Anxiety disorder; CRC cis rs4713118 0.824 rs9468223 chr6:27740666 C/T cg19041857 chr6:27730383 NA -0.46 -6.25 -0.33 1.28e-9 Parkinson's disease; CRC cis rs3741151 0.686 rs1002127 chr11:73103835 G/C cg17517138 chr11:73019481 ARHGEF17 0.6 6.21 0.32 1.62e-9 GIP levels in response to oral glucose tolerance test (120 minutes); CRC cis rs7772486 0.686 rs9399564 chr6:146078907 C/T cg13319975 chr6:146136371 FBXO30 0.44 6.69 0.35 9.7e-11 Lobe attachment (rater-scored or self-reported); CRC trans rs7615952 0.546 rs4428131 chr3:125346479 C/T cg02007433 chr3:129722099 NA -0.51 -6.2 -0.32 1.72e-9 Blood pressure (smoking interaction); CRC cis rs9916302 0.718 rs7219909 chr17:37706243 C/T cg00129232 chr17:37814104 STARD3 -0.56 -8.39 -0.42 1.42e-15 Glomerular filtration rate (creatinine); CRC trans rs9341835 0.740 rs9294198 chr6:64136993 T/C cg13657004 chr13:50234944 EBPL -0.36 -6.03 -0.32 4.42e-9 Schizophrenia; CRC cis rs5769765 0.773 rs9616378 chr22:50311973 A/G cg02269571 chr22:50332266 NA -0.61 -7.94 -0.4 3.13e-14 Schizophrenia; CRC cis rs3806843 0.966 rs2563265 chr5:140137005 C/T cg16607685 chr5:140181889 PCDHA2;PCDHA1;PCDHA3 0.25 5.84 0.31 1.22e-8 Depressive symptoms (multi-trait analysis); CRC cis rs41271473 0.526 rs942853 chr1:228730949 G/T cg16512390 chr1:228756714 NA 0.64 6.79 0.35 5.19e-11 Chronic lymphocytic leukemia; CRC cis rs7591163 1.000 rs1721359 chr2:228751874 C/T cg14646075 chr2:228736089 WDR69 -0.46 -6.22 -0.32 1.51e-9 Blood pressure; CRC cis rs6502050 0.835 rs3088177 chr17:80111724 A/G cg13198984 chr17:80129470 CCDC57 0.47 8.46 0.42 9.07e-16 Life satisfaction; CRC cis rs4332037 0.851 rs10268609 chr7:1962163 A/C cg23422044 chr7:1970798 MAD1L1 -0.59 -7.57 -0.39 3.68e-13 Bipolar disorder; CRC cis rs2836974 0.549 rs34160989 chr21:40554118 C/G cg17971929 chr21:40555470 PSMG1 0.58 5.99 0.31 5.36e-9 Cognitive function; CRC cis rs863345 0.504 rs857698 chr1:158561166 A/T cg12129480 chr1:158549410 OR10X1 -0.34 -7.17 -0.37 4.96e-12 Pneumococcal bacteremia; CRC cis rs736408 0.511 rs12637632 chr3:52708073 A/T cg07507251 chr3:52567010 NT5DC2 0.41 5.83 0.31 1.34e-8 Bipolar disorder; CRC cis rs7647973 0.626 rs2131108 chr3:49665390 C/T cg03060546 chr3:49711283 APEH 0.66 7.95 0.4 2.99e-14 Menarche (age at onset); CRC trans rs7829975 0.902 rs485107 chr8:8581408 C/G cg16141378 chr3:129829833 LOC729375 0.44 6.73 0.35 7.69e-11 Mood instability; CRC cis rs972578 1.000 rs6002997 chr22:43392264 A/G cg01576275 chr22:43409880 NA -0.49 -7.91 -0.4 3.96e-14 Mean platelet volume; CRC cis rs1215050 0.744 rs966380 chr4:98435389 C/T cg05340658 chr4:99064831 C4orf37 0.45 6.29 0.33 1.03e-9 Waist-to-hip ratio adjusted for body mass index; CRC cis rs7904985 0.961 rs12355013 chr10:88114538 A/G cg07322936 chr10:88137208 NA 0.46 6.28 0.33 1.05e-9 Barrett's esophagus; CRC cis rs9318086 0.600 rs9507185 chr13:24473734 G/A cg25267304 chr13:24462978 PCOTH;MIPEP 0.64 10.27 0.49 1.24e-21 Myopia (pathological); CRC cis rs4665809 0.590 rs13006973 chr2:26454707 C/T cg26119090 chr2:26468346 HADHA;HADHB 1.06 15.5 0.65 4.69e-41 Gut microbiome composition (summer); CRC cis rs2721195 0.719 rs4925811 chr8:145802447 G/T cg15857475 chr8:145742913 RECQL4;LRRC14 -0.7 -11.39 -0.53 1.47e-25 Age at first birth; CRC cis rs2404602 0.684 rs1011083 chr15:77007527 C/T cg23625390 chr15:77176239 SCAPER -0.88 -14.8 -0.63 2.43e-38 Blood metabolite levels; CRC cis rs3749237 0.595 rs10865955 chr3:49499829 G/A cg03060546 chr3:49711283 APEH 0.69 11.87 0.55 2.67e-27 Resting heart rate; CRC cis rs1823874 0.720 rs7162911 chr15:100355050 A/G cg16400843 chr15:100339927 C15orf51 0.31 5.71 0.3 2.53e-8 IgG glycosylation; CRC cis rs2070677 0.736 rs6537612 chr10:135336717 A/T cg20169779 chr10:135381914 SYCE1 -0.7 -6.61 -0.34 1.58e-10 Gout; CRC trans rs57221529 0.766 rs56278696 chr5:582669 A/G cg11887960 chr12:57824829 NA 0.63 6.89 0.36 2.93e-11 Lung disease severity in cystic fibrosis; CRC cis rs116095464 0.558 rs9654453 chr5:299621 T/C cg22857025 chr5:266934 NA -1.16 -11.79 -0.54 5.48e-27 Breast cancer; CRC cis rs3106136 1.000 rs2664871 chr4:95146281 A/G cg11021082 chr4:95130006 SMARCAD1 0.47 7.3 0.37 2.17e-12 Capecitabine sensitivity; CRC cis rs2032447 0.765 rs6942072 chr6:26014987 A/G cg18357526 chr6:26021779 HIST1H4A 0.74 11.53 0.54 4.71e-26 Intelligence (multi-trait analysis); CRC cis rs12760731 0.623 rs10798608 chr1:178386753 A/G cg00404053 chr1:178313656 RASAL2 0.73 9.02 0.45 1.62e-17 Obesity-related traits; CRC cis rs6570726 0.643 rs9403735 chr6:145936591 C/T cg13319975 chr6:146136371 FBXO30 -0.48 -7.06 -0.36 9.85e-12 Lobe attachment (rater-scored or self-reported); CRC cis rs877282 0.891 rs11253406 chr10:796297 G/A cg17470449 chr10:769945 NA 0.68 9.03 0.45 1.48e-17 Uric acid levels; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg25372275 chr1:161102558 DEDD 0.36 5.97 0.31 6.29e-9 Liver disease severity in Alagille syndrome; CRC cis rs67981189 0.570 rs67188216 chr14:71509324 T/A cg15910301 chr14:71632612 NA 0.31 6.14 0.32 2.41e-9 Schizophrenia; CRC trans rs11295209 1 rs11295209 chr4:120480233 TA/T cg25214090 chr10:38739885 LOC399744 -0.42 -6.47 -0.34 3.48e-10 Plateletcrit; CRC cis rs1843834 0.539 rs6713629 chr2:225410973 A/T cg22455342 chr2:225449267 CUL3 0.63 8.51 0.42 6.14e-16 IgE levels in asthmatics (D.p. specific); CRC cis rs17345786 0.511 rs13061565 chr3:101392270 T/C cg11279151 chr3:101281821 RG9MTD1 -0.57 -7.74 -0.39 1.25e-13 Colonoscopy-negative controls vs population controls; CRC cis rs7618915 0.501 rs767418 chr3:52767427 C/T cg15147215 chr3:52552868 STAB1 -0.63 -10.74 -0.51 2.95e-23 Bipolar disorder; CRC cis rs7727544 0.904 rs7736102 chr5:131604257 G/A cg04518342 chr5:131593106 PDLIM4 0.36 6.72 0.35 8.18e-11 Blood metabolite levels; CRC cis rs2011503 0.941 rs55762233 chr19:19367319 C/G cg11584989 chr19:19387371 SF4 0.56 6.67 0.34 1.11e-10 Bipolar disorder; CRC cis rs11645898 0.935 rs4788614 chr16:72188828 C/T cg14768367 chr16:72042858 DHODH 0.51 5.9 0.31 8.87e-9 Blood protein levels; CRC trans rs3942852 0.868 rs7122335 chr11:48106486 C/T cg03929089 chr4:120376271 NA -0.53 -6.13 -0.32 2.47e-9 Acute lymphoblastic leukemia (childhood); CRC cis rs6701037 0.566 rs1014555 chr1:175134249 C/T cg17845761 chr1:175162550 KIAA0040 0.3 6.44 0.33 4.23e-10 Alcohol dependence; CRC cis rs208520 0.690 rs851459 chr6:66813989 A/G cg07460842 chr6:66804631 NA -1.09 -15.35 -0.65 1.82e-40 Exhaled nitric oxide output; CRC cis rs10504229 0.679 rs17804870 chr8:58158071 A/G cg02725872 chr8:58115012 NA -0.56 -7.24 -0.37 3.15e-12 Developmental language disorder (linguistic errors); CRC cis rs11098499 0.739 rs9996382 chr4:120151012 C/T cg09307838 chr4:120376055 NA 0.53 8.31 0.42 2.56e-15 Corneal astigmatism; CRC cis rs6761276 0.934 rs11682107 chr2:113835522 G/A cg09040174 chr2:113837401 NA 0.67 10.7 0.51 4.04e-23 Protein quantitative trait loci; CRC cis rs4629710 0.592 rs9492865 chr6:131534403 T/A cg12606694 chr6:131520996 AKAP7 0.55 8.05 0.41 1.57e-14 Multiple myeloma (IgH translocation); CRC trans rs7726839 0.507 rs72703100 chr5:614291 C/T cg11887960 chr12:57824829 NA 0.58 6.5 0.34 3.04e-10 Obesity-related traits; CRC cis rs1799949 0.860 rs8176279 chr17:41210396 A/C cg23758822 chr17:41437982 NA 0.85 15.86 0.66 1.72e-42 Menopause (age at onset); CRC cis rs7202877 0.706 rs11149812 chr16:75323645 T/C cg03315344 chr16:75512273 CHST6 0.49 5.61 0.3 4.28e-8 Type 2 diabetes;Type 1 diabetes; CRC trans rs2727020 0.619 rs11040300 chr11:49269984 C/A cg15704280 chr7:45808275 SEPT13 0.62 8.16 0.41 7.21e-15 Coronary artery disease; CRC cis rs7208859 0.623 rs9906957 chr17:29157755 C/T cg14008862 chr17:28927542 LRRC37B2 0.56 5.93 0.31 7.65e-9 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs3749237 0.595 rs11720264 chr3:49580347 C/T cg03060546 chr3:49711283 APEH 0.69 12.02 0.55 7.72e-28 Resting heart rate; CRC cis rs853679 0.542 rs34131763 chr6:28075000 A/C cg15786705 chr6:28176104 NA 0.76 9.6 0.47 2.1e-19 Depression; CRC cis rs2243480 0.901 rs35823062 chr7:65965821 A/G cg25985355 chr7:65971099 NA -0.52 -6.0 -0.31 5.12e-9 Diabetic kidney disease; CRC cis rs4319547 0.695 rs6489002 chr12:122929822 T/C cg23029597 chr12:123009494 RSRC2 -0.55 -6.86 -0.35 3.34e-11 Body mass index; CRC cis rs9811920 0.609 rs7638900 chr3:99670773 T/C cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G -0.46 -6.09 -0.32 3.12e-9 Axial length; CRC cis rs1957429 0.901 rs1467569 chr14:65347986 T/C cg23373153 chr14:65346875 NA 0.79 8.25 0.41 3.9e-15 Pediatric areal bone mineral density (radius); CRC cis rs644799 0.710 rs519511 chr11:95538270 G/A cg25478527 chr11:95522999 CEP57;FAM76B 0.48 7.52 0.38 5.35e-13 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs9372498 0.536 rs62422227 chr6:118957200 C/G cg07617317 chr6:118971624 C6orf204 0.47 5.69 0.3 2.79e-8 Diastolic blood pressure; CRC cis rs11190604 1.000 rs7073586 chr10:102307671 A/G cg07080220 chr10:102295463 HIF1AN 0.47 6.1 0.32 2.99e-9 Palmitoleic acid (16:1n-7) levels; CRC cis rs8180040 0.800 rs2088135 chr3:47280018 T/C cg27129171 chr3:47204927 SETD2 -0.68 -10.39 -0.5 4.54e-22 Colorectal cancer; CRC cis rs7953508 0.506 rs2200160 chr12:93963873 C/T cg18151635 chr12:93972918 NA -0.8 -11.58 -0.54 2.97e-26 Pubertal anthropometrics; CRC cis rs4731207 0.506 rs12531282 chr7:124625462 A/G cg23710748 chr7:124431027 NA -0.39 -6.25 -0.33 1.29e-9 Cutaneous malignant melanoma; CRC cis rs1670533 0.818 rs6835141 chr4:1070140 G/T cg27284194 chr4:1044797 NA 0.5 6.39 0.33 5.61e-10 Recombination rate (females); CRC cis rs2718058 0.519 rs2598071 chr7:37875347 G/A cg24998770 chr7:37888106 TXNDC3 0.39 6.15 0.32 2.31e-9 Alzheimer's disease (late onset); CRC cis rs17345786 0.911 rs10936707 chr3:101324063 G/A cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.56 6.62 0.34 1.46e-10 Colonoscopy-negative controls vs population controls; CRC cis rs208515 0.556 rs10455193 chr6:66691456 G/A cg07460842 chr6:66804631 NA 0.97 12.24 0.56 1.17e-28 Exhaled nitric oxide levels; CRC cis rs826838 1.000 rs4575342 chr12:38663831 G/A cg13010199 chr12:38710504 ALG10B 0.46 6.1 0.32 2.98e-9 Heart rate; CRC trans rs7647973 0.710 rs12637313 chr3:49645458 A/G cg21665057 chr3:196295764 WDR53;FBXO45 -0.65 -6.96 -0.36 1.83e-11 Menarche (age at onset); CRC cis rs801193 1.000 rs62466794 chr7:66191579 G/A cg05627663 chr7:65219948 SNORA22;CCT6P1 0.41 5.94 0.31 7.33e-9 Aortic root size; CRC cis rs10782582 0.593 rs12126155 chr1:76131555 C/G cg03433033 chr1:76189801 ACADM -0.43 -6.17 -0.32 2.06e-9 Daytime sleep phenotypes; CRC cis rs6502050 0.835 rs8065210 chr17:80090960 G/A cg13198984 chr17:80129470 CCDC57 0.47 8.43 0.42 1.09e-15 Life satisfaction; CRC cis rs995000 0.899 rs12136083 chr1:63163073 T/C cg19896129 chr1:63156450 NA 0.4 5.92 0.31 8.23e-9 Triglyceride levels; CRC cis rs8031584 0.958 rs11293 chr15:31234981 G/A cg08109568 chr15:31115862 NA -0.55 -8.81 -0.44 7.36e-17 Huntington's disease progression; CRC cis rs4862750 0.915 rs6835681 chr4:187903476 A/G cg27532560 chr4:187881888 NA -0.54 -9.6 -0.47 2.19e-19 Lobe attachment (rater-scored or self-reported); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg07017275 chr14:55738748 FBXO34 0.36 6.05 0.32 4.02e-9 Liver disease severity in Alagille syndrome; CRC cis rs8177253 1.000 rs6439439 chr3:133481498 G/T cg16262614 chr3:133464971 TF 0.33 5.92 0.31 7.97e-9 Iron status biomarkers; CRC cis rs2204008 0.715 rs12815986 chr12:38343869 G/A cg26384229 chr12:38710491 ALG10B 0.68 9.17 0.45 5.45e-18 Bladder cancer; CRC cis rs9611565 0.532 rs202627 chr22:41847367 A/T cg03806693 chr22:41940476 POLR3H 0.96 12.99 0.58 2.02e-31 Vitiligo; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg22146484 chr8:57123862 CHCHD7;PLAG1 0.4 6.05 0.32 3.89e-9 Intelligence (multi-trait analysis); CRC cis rs4285028 0.699 rs1344279 chr3:121615679 G/A cg11130432 chr3:121712080 ILDR1 -0.51 -6.08 -0.32 3.37e-9 Multiple sclerosis; CRC cis rs9875589 0.957 rs13077668 chr3:13929756 A/G cg19554555 chr3:13937349 NA -0.52 -7.87 -0.4 5.3e-14 Ovarian reserve; CRC cis rs10504229 0.683 rs7464038 chr8:58111908 T/C cg22535103 chr8:58192502 C8orf71 -0.72 -9.25 -0.45 2.91e-18 Developmental language disorder (linguistic errors); CRC cis rs734999 0.588 rs3001837 chr1:2532506 G/A cg20673091 chr1:2541236 MMEL1 -0.36 -5.79 -0.3 1.67e-8 Ulcerative colitis; CRC cis rs6502050 0.835 rs11654584 chr17:80079435 A/T cg25804541 chr17:80189381 SLC16A3 -0.3 -5.66 -0.3 3.22e-8 Life satisfaction; CRC cis rs4474465 1.000 rs11237522 chr11:78209879 A/G cg27205649 chr11:78285834 NARS2 -0.45 -5.62 -0.3 4e-8 Alzheimer's disease (survival time); CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg24306779 chr16:58060336 MMP15 -0.58 -7.26 -0.37 2.75e-12 Diisocyanate-induced asthma; CRC cis rs12190007 0.547 rs3006179 chr6:169822467 C/G cg15342139 chr6:170124938 PHF10 0.34 5.7 0.3 2.6e-8 Obesity-related traits; CRC cis rs6502050 0.835 rs6502067 chr17:80111205 A/G cg09264619 chr17:80180166 NA -0.34 -5.81 -0.3 1.5e-8 Life satisfaction; CRC cis rs2404602 0.716 rs4886813 chr15:76838221 C/T cg23625390 chr15:77176239 SCAPER -0.48 -7.01 -0.36 1.33e-11 Blood metabolite levels; CRC cis rs9467711 0.591 rs9295675 chr6:25918473 C/T cg08501292 chr6:25962987 TRIM38 0.93 9.06 0.45 1.19e-17 Autism spectrum disorder or schizophrenia; CRC cis rs4862750 0.872 rs7671914 chr4:187878165 A/G cg10295955 chr4:187884368 NA -1.02 -25.23 -0.81 6.66e-79 Lobe attachment (rater-scored or self-reported); CRC cis rs7927592 0.956 rs12271290 chr11:68326236 A/G cg01657329 chr11:68192670 LRP5 0.47 6.93 0.36 2.2e-11 Total body bone mineral density; CRC cis rs6429082 0.871 rs9662392 chr1:235576949 G/T cg26050004 chr1:235667680 B3GALNT2 -0.4 -5.86 -0.31 1.1e-8 Adiposity; CRC cis rs2811415 0.627 rs1549873 chr3:127769599 G/A cg13719885 chr3:127795394 NA -0.4 -6.05 -0.32 3.99e-9 Lung function (FEV1/FVC); CRC cis rs10504229 0.953 rs67677367 chr8:58175264 T/G cg24829409 chr8:58192753 C8orf71 -0.68 -11.34 -0.53 2.27e-25 Developmental language disorder (linguistic errors); CRC cis rs2530545 0.851 rs60341215 chr7:34680796 G/A cg14401837 chr7:34697493 NPSR1 0.41 5.61 0.3 4.23e-8 IgG glycosylation; CRC cis rs853679 0.517 rs9393896 chr6:28127703 C/T cg02631126 chr6:28058918 ZSCAN12L1 0.29 5.91 0.31 8.38e-9 Depression; CRC cis rs7917772 0.619 rs2251772 chr10:104470918 T/C cg04362960 chr10:104952993 NT5C2 -0.5 -6.01 -0.31 4.8e-9 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC cis rs2455601 0.786 rs11042127 chr11:8947586 C/G cg21881798 chr11:8931708 C11orf17;ST5 -0.58 -6.62 -0.34 1.45e-10 Schizophrenia; CRC trans rs951252 0.504 rs11734405 chr4:146081096 C/T cg02684603 chr4:89445054 PIGY 0.47 6.07 0.32 3.53e-9 Hip circumference; CRC cis rs10504229 0.593 rs16921626 chr8:58040359 C/T cg02290350 chr8:58132656 NA -0.43 -5.64 -0.3 3.68e-8 Developmental language disorder (linguistic errors); CRC trans rs7615952 0.512 rs2922175 chr3:125361360 T/C cg21747405 chr11:67723411 NA -0.58 -9.13 -0.45 6.88e-18 Blood pressure (smoking interaction); CRC cis rs4237845 0.537 rs10747786 chr12:58260601 G/T cg00677455 chr12:58241039 CTDSP2 0.76 11.67 0.54 1.41e-26 Intelligence (multi-trait analysis); CRC cis rs80207740 0.941 rs2076940 chr8:21836020 A/G cg25597362 chr8:21767310 DOK2 -0.56 -6.25 -0.33 1.28e-9 Mean corpuscular hemoglobin; CRC cis rs11214589 0.747 rs11493880 chr11:113225144 C/T cg14159747 chr11:113255604 NA 0.51 9.38 0.46 1.15e-18 Neuroticism; CRC cis rs4073416 0.508 rs11844682 chr14:65910844 G/C cg03016385 chr14:66212404 NA -0.42 -5.69 -0.3 2.86e-8 N-glycan levels; CRC cis rs477895 0.713 rs12787852 chr11:63954648 G/A cg18225595 chr11:63971243 STIP1 0.61 8.1 0.41 1.08e-14 Mean platelet volume; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg15356674 chr10:79471309 NA 0.44 5.98 0.31 5.75e-9 Thyroid stimulating hormone; CRC cis rs9733 0.818 rs11204702 chr1:150663507 C/A cg17724175 chr1:150552817 MCL1 -0.46 -7.22 -0.37 3.54e-12 Tonsillectomy; CRC cis rs9467160 0.644 rs62400468 chr6:24457358 C/T cg20631270 chr6:24437470 GPLD1 0.48 5.9 0.31 8.8e-9 Liver enzyme levels; CRC cis rs798554 0.660 rs2644296 chr7:2859061 A/T cg19717773 chr7:2847554 GNA12 -0.47 -8.0 -0.4 2.12e-14 Height; CRC cis rs9435341 0.965 rs1762482 chr1:107599002 A/C cg14828511 chr1:107599125 PRMT6 -0.53 -7.62 -0.39 2.79e-13 Facial morphology (factor 21, depth of nasal alae); CRC cis rs483180 0.532 rs561931 chr1:120254506 A/G cg19096424 chr1:120255104 PHGDH 0.51 7.41 0.38 1.11e-12 Macular telangiectasia type 2; CRC cis rs7635838 0.892 rs66974661 chr3:11482729 A/G cg00170343 chr3:11313890 ATG7 0.42 6.46 0.34 3.82e-10 HDL cholesterol; CRC cis rs35110281 0.659 rs73367822 chr21:45024252 C/T cg01579765 chr21:45077557 HSF2BP -0.38 -7.19 -0.37 4.32e-12 Mean corpuscular volume; CRC cis rs644799 0.931 rs496305 chr11:95567035 C/T cg25478527 chr11:95522999 CEP57;FAM76B 0.52 7.77 0.39 1.03e-13 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs735396 0.770 rs2257764 chr12:121446446 T/A cg02403541 chr12:121454288 C12orf43 -0.48 -7.13 -0.37 6.3e-12 N-glycan levels; CRC cis rs34172651 0.874 rs200534 chr16:24752641 G/A cg06505273 chr16:24850292 NA -0.39 -5.71 -0.3 2.59e-8 Intelligence (multi-trait analysis); CRC trans rs6598955 0.671 rs41285347 chr1:26644399 C/T cg07461501 chr17:79650226 HGS;ARL16 -0.55 -6.45 -0.34 3.9e-10 Obesity-related traits; CRC cis rs769267 0.859 rs2916076 chr19:19545990 T/C cg02546618 chr19:19431379 KIAA0892;SF4 0.46 6.43 0.33 4.57e-10 Tonsillectomy; CRC trans rs1005277 0.579 rs11011461 chr10:38431427 G/A cg11292332 chr7:45801988 SEPT13 -0.35 -6.25 -0.33 1.3e-9 Extrinsic epigenetic age acceleration; CRC cis rs9611565 0.659 rs9611604 chr22:41916001 C/G cg06634786 chr22:41940651 POLR3H -0.67 -7.59 -0.39 3.41e-13 Vitiligo; CRC trans rs1814175 0.817 rs7932683 chr11:49983640 G/A cg21153622 chr11:89784906 NA -0.37 -5.97 -0.31 6.05e-9 Height; CRC cis rs2952156 0.920 rs2517959 chr17:37846512 A/T cg20243544 chr17:37824526 PNMT 0.56 8.6 0.43 3.35e-16 Asthma; CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg15877295 chr7:138915876 UBN2 -0.53 -6.49 -0.34 3.21e-10 Diisocyanate-induced asthma; CRC cis rs10504229 0.683 rs73603877 chr8:58108428 C/T cg05313129 chr8:58192883 C8orf71 -0.43 -5.83 -0.31 1.36e-8 Developmental language disorder (linguistic errors); CRC cis rs2153535 0.580 rs2327067 chr6:8518482 C/G cg21535247 chr6:8435926 SLC35B3 0.48 7.36 0.38 1.51e-12 Motion sickness; CRC cis rs875971 0.545 rs73142265 chr7:65699497 G/A cg05627663 chr7:65219948 SNORA22;CCT6P1 0.63 8.11 0.41 1.04e-14 Aortic root size; CRC trans rs12200782 0.577 rs12208220 chr6:26382635 C/G cg25800765 chr12:85673347 ALX1 0.26 5.96 0.31 6.54e-9 Small cell lung carcinoma; CRC cis rs8060686 0.545 rs7199878 chr16:68186301 A/G cg26727032 chr16:67993705 SLC12A4 -0.53 -5.78 -0.3 1.76e-8 HDL cholesterol;Metabolic syndrome; CRC cis rs9322193 0.923 rs10747275 chr6:149943918 C/T cg05861140 chr6:150128134 PCMT1 -0.36 -5.85 -0.31 1.19e-8 Lung cancer; CRC cis rs6942756 0.955 rs55638303 chr7:128885770 C/T cg02491457 chr7:128862824 NA -0.75 -10.02 -0.48 8.31e-21 White matter hyperintensity burden; CRC trans rs944990 0.595 rs10123378 chr9:96375217 C/T cg26873254 chr8:144332526 ZFP41 -0.39 -6.11 -0.32 2.84e-9 Body mass index; CRC cis rs713477 0.967 rs6573028 chr14:55913397 C/T cg13175173 chr14:55914753 NA -0.52 -9.9 -0.48 2.06e-20 Pediatric bone mineral content (femoral neck); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg02189786 chr16:67875959 THAP11;CENPT 0.42 6.3 0.33 9.37e-10 Response to antipsychotic treatment; CRC cis rs798554 0.679 rs1614791 chr7:2888057 G/T cg04166393 chr7:2884313 GNA12 0.56 7.52 0.38 5.12e-13 Height; CRC cis rs2976388 1.000 rs1045547 chr8:143763757 T/G cg20041105 chr8:143859282 LYNX1 -0.32 -5.7 -0.3 2.64e-8 Urinary tract infection frequency; CRC cis rs753778 0.602 rs9792 chr8:142205237 C/T cg23750338 chr8:142222470 SLC45A4 -0.45 -7.85 -0.4 6.07e-14 Reticulocyte fraction of red cells;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; CRC cis rs7809950 1.000 rs1544336 chr7:107082415 G/C cg23024343 chr7:107201750 COG5 -0.6 -8.65 -0.43 2.37e-16 Coronary artery disease; CRC trans rs1814175 0.645 rs866427 chr11:49923853 G/A cg03929089 chr4:120376271 NA -0.91 -16.07 -0.66 2.65e-43 Height; CRC cis rs8060686 0.623 rs7201591 chr16:68086105 A/G cg26727032 chr16:67993705 SLC12A4 -0.63 -9.75 -0.47 6.71e-20 HDL cholesterol;Metabolic syndrome; CRC cis rs853679 0.517 rs9393893 chr6:28109262 T/C cg15786705 chr6:28176104 NA 0.78 9.83 0.48 3.57e-20 Depression; CRC cis rs7267979 0.816 rs443009 chr20:25499817 A/G cg24626310 chr20:25276739 ABHD12;PYGB -0.37 -6.62 -0.34 1.47e-10 Liver enzyme levels (alkaline phosphatase); CRC trans rs1814175 0.619 rs10769623 chr11:49865926 C/T cg03929089 chr4:120376271 NA -0.9 -15.52 -0.65 3.9e-41 Height; CRC cis rs1552244 1.000 rs7622963 chr3:10139825 C/T cg13047869 chr3:10149882 C3orf24 0.51 7.34 0.37 1.72e-12 Alzheimer's disease; CRC cis rs17767392 0.834 rs61991190 chr14:71737278 T/C cg13720639 chr14:72061746 SIPA1L1 -0.54 -6.56 -0.34 2.1e-10 Mitral valve prolapse; CRC cis rs9902453 0.967 rs9900911 chr17:28330280 T/G cg26525008 chr17:28256777 EFCAB5;SSH2 -0.59 -8.83 -0.44 6.18e-17 Coffee consumption (cups per day); CRC cis rs11212617 0.967 rs186594 chr11:108265854 A/T cg14761454 chr11:108092087 ATM;NPAT 0.44 6.64 0.34 1.3e-10 Response to metformin in type 2 diabetes (glycemic); CRC cis rs9341808 0.644 rs76102095 chr6:80942026 G/C cg08355045 chr6:80787529 NA -0.36 -6.05 -0.32 4.01e-9 Sitting height ratio; CRC cis rs17155006 0.676 rs424866 chr7:107722869 T/C cg05962710 chr7:107745446 LAMB4 -0.36 -5.85 -0.31 1.17e-8 Pneumococcal bacteremia; CRC cis rs12200560 0.505 rs211166 chr6:97068598 T/C cg06623918 chr6:96969491 KIAA0776 0.5 7.35 0.38 1.54e-12 Coronary heart disease; CRC cis rs12477438 0.520 rs11890338 chr2:99767868 C/T cg14399236 chr2:99771627 LIPT1;TSGA10 0.82 14.44 0.62 5.96e-37 Chronic sinus infection; CRC trans rs587242 1.000 rs2011693 chr1:96884287 G/A cg10631902 chr5:14652156 NA 0.45 7.01 0.36 1.33e-11 Body mass index (joint analysis main effects and physical activity interaction);Body mass index in physically inactive individuals;Body mass index; CRC cis rs10540 1.000 rs61876323 chr11:462855 G/A cg03576123 chr11:487126 PTDSS2 -1.01 -10.5 -0.5 2e-22 Body mass index; CRC cis rs28830936 0.625 rs8038764 chr15:41907905 A/C cg17847044 chr15:42102381 MAPKBP1 0.34 8.28 0.42 3.1e-15 Diastolic blood pressure; CRC cis rs1790761 0.504 rs61894496 chr11:67391907 C/T cg00290607 chr11:67383545 NA 0.44 7.61 0.39 3.01e-13 Mean corpuscular volume; CRC cis rs6540559 0.673 rs58637469 chr1:209971480 T/A cg23283495 chr1:209979779 IRF6 0.48 6.81 0.35 4.66e-11 Cleft lip with or without cleft palate; CRC cis rs2969070 0.898 rs2906165 chr7:2508177 T/C cg03277898 chr7:2518824 NA -0.41 -5.89 -0.31 9.75e-9 Diastolic blood pressure; CRC cis rs7618501 0.602 rs10049087 chr3:50123417 A/G cg24308560 chr3:49941425 MST1R 0.48 7.6 0.39 3.19e-13 Intelligence (multi-trait analysis); CRC cis rs174479 0.677 rs1000778 chr11:61655305 A/G cg01500311 chr11:61656094 FADS3 0.35 5.66 0.3 3.27e-8 Sphingolipid levels; CRC trans rs9585327 0.584 rs4772260 chr13:100645723 A/G cg18811860 chr17:31264143 TMEM98 0.37 6.19 0.32 1.82e-9 Myopia; CRC cis rs11971779 0.680 rs10265718 chr7:139100068 G/A cg07862535 chr7:139043722 LUC7L2 0.57 7.32 0.37 1.92e-12 Diisocyanate-induced asthma; CRC cis rs9902453 1.000 rs7212497 chr17:28335949 T/G cg26525008 chr17:28256777 EFCAB5;SSH2 -0.59 -8.79 -0.44 8.24e-17 Coffee consumption (cups per day); CRC cis rs1577917 0.958 rs34795473 chr6:86461799 C/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.52 -6.91 -0.36 2.5e-11 Response to antipsychotic treatment; CRC cis rs2933343 0.621 rs728838 chr3:128589013 A/G cg11901034 chr3:128598214 ACAD9 -0.56 -8.33 -0.42 2.21e-15 IgG glycosylation; CRC cis rs10128264 0.902 rs1250587 chr10:80978021 A/G cg20744163 chr10:80999841 ZMIZ1 -0.43 -7.39 -0.38 1.19e-12 Response to methotrexate in juvenile idiopathic arthritis; CRC cis rs4566357 0.557 rs6707158 chr2:227911269 A/G cg11843606 chr2:227700838 RHBDD1 -0.44 -6.85 -0.35 3.54e-11 Coronary artery disease; CRC cis rs1865760 0.573 rs7450342 chr6:25919480 T/C cg03517284 chr6:25882590 NA -0.41 -6.07 -0.32 3.47e-9 Height; CRC cis rs12142240 0.698 rs79490411 chr1:46813568 G/A cg14993813 chr1:46806288 NSUN4 -0.49 -5.77 -0.3 1.86e-8 Menopause (age at onset); CRC trans rs2795502 0.882 rs2744087 chr10:43340270 A/C cg06791473 chr12:49259579 RND1 0.61 5.99 0.31 5.45e-9 Blood protein levels; CRC cis rs45509595 0.841 rs200485 chr6:27775697 G/C cg26958806 chr6:27640298 NA 0.67 5.87 0.31 1.05e-8 Breast cancer; CRC cis rs887829 0.588 rs7556676 chr2:234658250 A/G cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.52 -8.1 -0.41 1.07e-14 Metabolic traits;Bilirubin levels;Cholelithiasis-related traits in sickle cell anemia;Metabolite levels;Total bilirubin levels in HIV-1 infection;Serum metabolite levels;Blood metabolite levels; CRC trans rs11989122 0.517 rs10955831 chr8:118809805 G/T cg02216535 chr4:85308929 NA -0.39 -6.41 -0.33 5.02e-10 Height; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg13713052 chr3:122102218 FAM162A;CCDC58 0.45 6.48 0.34 3.33e-10 Response to antipsychotic treatment; CRC cis rs863345 0.604 rs12122663 chr1:158506724 A/G cg12129480 chr1:158549410 OR10X1 -0.3 -6.27 -0.33 1.12e-9 Pneumococcal bacteremia; CRC cis rs7546094 1.000 rs6537743 chr1:113092527 A/G cg22162597 chr1:113214053 CAPZA1 0.42 5.84 0.31 1.27e-8 Platelet distribution width; CRC cis rs9400239 0.622 rs1268165 chr6:109008378 A/G cg11073813 chr6:109029018 NA -0.39 -6.21 -0.32 1.59e-9 Waist circumference;Body mass index;BMI (adjusted for smoking behaviour); CRC cis rs9787249 0.874 rs7520588 chr1:40214525 T/A cg19912559 chr1:40204330 PPIE 0.52 7.68 0.39 1.82e-13 Blood protein levels; CRC cis rs832540 0.966 rs33321 chr5:56206073 G/T cg12311346 chr5:56204834 C5orf35 -0.5 -7.71 -0.39 1.53e-13 Coronary artery disease; CRC cis rs12497850 0.966 rs6792510 chr3:48723302 G/C cg20833759 chr3:49053208 WDR6;DALRD3 0.42 7.23 0.37 3.36e-12 Parkinson's disease; CRC trans rs9868809 0.881 rs13076269 chr3:48675925 T/C cg03060546 chr3:49711283 APEH -0.57 -6.1 -0.32 3.01e-9 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; CRC cis rs40363 0.723 rs4785936 chr16:3535116 A/G cg22508957 chr16:3507546 NAT15 -0.77 -8.41 -0.42 1.29e-15 Tuberculosis; CRC cis rs9329289 0.603 rs2458698 chr10:2548452 C/T cg18171855 chr10:2543474 NA 0.36 5.84 0.31 1.24e-8 Age-related hearing impairment; CRC cis rs4819052 0.724 rs1304487 chr21:46657283 C/G cg19498844 chr21:46707878 POFUT2;LOC642852 -0.66 -9.58 -0.47 2.46e-19 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs11167764 1.000 rs7722567 chr5:141483178 C/T cg08523384 chr5:141488047 NDFIP1 -0.51 -8.36 -0.42 1.8e-15 Crohn's disease; CRC cis rs728616 0.558 rs2343302 chr10:82163186 A/G cg11900509 chr10:81946545 ANXA11 -0.56 -6.24 -0.33 1.32e-9 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs9287719 0.901 rs6432109 chr2:10736821 A/G cg00105475 chr2:10696890 NA 0.45 7.3 0.37 2.19e-12 Prostate cancer; CRC cis rs6585424 1.000 rs61860035 chr10:81932453 C/G cg11900509 chr10:81946545 ANXA11 -0.76 -9.32 -0.46 1.78e-18 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs727505 0.954 rs1383748 chr7:124638201 A/T cg23710748 chr7:124431027 NA -0.81 -14.21 -0.62 4.64e-36 Lewy body disease; CRC cis rs55823223 0.564 rs4572466 chr17:73846314 A/C cg10935138 chr17:73851978 WBP2 0.54 6.64 0.34 1.32e-10 Psoriasis; CRC cis rs2019137 0.967 rs902695 chr2:113955074 G/A cg21482265 chr2:113992762 PAX8;LOC440839;LOC654433 -0.46 -6.57 -0.34 1.97e-10 Lymphocyte counts; CRC cis rs6754311 0.731 rs12988076 chr2:136569848 C/A cg25344623 chr2:136566232 LCT 0.32 5.81 0.31 1.47e-8 Mosquito bite size; CRC cis rs1552244 0.938 rs34750074 chr3:10091740 G/A cg00166722 chr3:10149974 C3orf24 0.7 9.43 0.46 7.84e-19 Alzheimer's disease; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg27629044 chr12:132628994 DDX51;NOC4L -0.4 -6.1 -0.32 2.93e-9 Myopia (pathological); CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg06034874 chr16:75285194 BCAR1 -0.43 -5.99 -0.31 5.36e-9 Myopia (pathological); CRC cis rs1552244 0.882 rs3755782 chr3:10029305 T/C cg02579736 chr3:10068473 FANCD2;CIDECP 0.93 11.94 0.55 1.55e-27 Alzheimer's disease; CRC cis rs72634258 0.945 rs6577459 chr1:8100173 G/T cg00042356 chr1:8021962 PARK7 0.66 7.17 0.37 4.94e-12 Inflammatory bowel disease; CRC cis rs9443645 0.901 rs9361488 chr6:79782874 T/C cg09184832 chr6:79620586 NA -0.49 -8.98 -0.44 2.2e-17 Intelligence (multi-trait analysis); CRC cis rs9399135 0.869 rs9402675 chr6:135325794 C/G cg22676075 chr6:135203613 NA 0.41 6.38 0.33 6.03e-10 Red blood cell count; CRC cis rs12701220 0.744 rs2030958 chr7:1076010 G/T cg00990874 chr7:1149470 C7orf50 -0.56 -6.44 -0.33 4.36e-10 Bronchopulmonary dysplasia; CRC cis rs4713118 0.513 rs1225591 chr6:28148752 G/A cg21251018 chr6:28226885 NKAPL 0.47 7.04 0.36 1.13e-11 Parkinson's disease; CRC cis rs60871478 1.000 rs9195 chr7:825786 C/T cg13844804 chr7:814759 HEATR2 -0.6 -8.03 -0.4 1.81e-14 Cerebrospinal P-tau181p levels; CRC cis rs7113874 0.569 rs11041999 chr11:8605739 T/C cg17679104 chr11:8615758 STK33 0.35 5.93 0.31 7.48e-9 Body mass index in physically active individuals;Body mass index (joint analysis main effects and physical activity interaction); CRC trans rs7395662 0.593 rs8188975 chr11:48891877 A/G cg21153622 chr11:89784906 NA 0.46 7.31 0.37 2.09e-12 HDL cholesterol; CRC cis rs1733410 0.504 rs11181874 chr12:37912890 C/A cg26384229 chr12:38710491 ALG10B -0.63 -9.63 -0.47 1.65e-19 Morning vs. evening chronotype; CRC trans rs2727020 0.729 rs10839268 chr11:49380328 G/A cg21153622 chr11:89784906 NA -0.41 -6.78 -0.35 5.45e-11 Coronary artery disease; CRC cis rs7259376 0.936 rs8110854 chr19:22549453 C/T cg02657401 chr19:22469223 NA -0.31 -6.76 -0.35 6.13e-11 Menopause (age at onset); CRC cis rs4665809 1.000 rs6546766 chr2:26328680 T/C cg27170947 chr2:26402098 FAM59B -0.45 -5.97 -0.31 6.09e-9 Gut microbiome composition (summer); CRC cis rs6598955 0.671 rs12085416 chr1:26627835 T/C cg04990556 chr1:26633338 UBXN11 0.52 5.68 0.3 3.04e-8 Obesity-related traits; CRC cis rs6665290 0.904 rs6690803 chr1:227189106 C/T cg10327440 chr1:227177885 CDC42BPA -1.03 -22.03 -0.77 1.02e-66 Myeloid white cell count; CRC cis rs7474896 0.583 rs11011347 chr10:38019264 G/A cg25427524 chr10:38739819 LOC399744 -0.61 -7.69 -0.39 1.72e-13 Obesity (extreme); CRC cis rs9549367 0.789 rs2287244 chr13:113887173 C/G cg00898013 chr13:113819073 PROZ 0.42 6.35 0.33 7.08e-10 Platelet distribution width; CRC cis rs11628318 0.660 rs8009475 chr14:103058608 A/G cg08075719 chr14:103021372 NA -0.68 -7.91 -0.4 3.94e-14 Platelet count; CRC trans rs11148252 0.595 rs4885325 chr13:53171317 C/T cg18335740 chr13:41363409 SLC25A15 0.75 13.68 0.6 4.93e-34 Lewy body disease; CRC cis rs10221833 0.602 rs355884 chr2:165633933 C/A cg03182029 chr2:165697222 COBLL1 0.5 5.83 0.31 1.35e-8 Response to statin therapy; CRC trans rs1997103 0.954 rs4947505 chr7:55409448 T/C cg20935933 chr6:143382018 AIG1 0.5 6.46 0.34 3.68e-10 QRS interval (sulfonylurea treatment interaction); CRC trans rs7819412 0.775 rs4545055 chr8:10935366 T/C cg16141378 chr3:129829833 LOC729375 0.46 6.55 0.34 2.21e-10 Triglycerides; CRC cis rs1799949 0.859 rs11657004 chr17:41442751 A/G cg19454999 chr17:41278357 BRCA1;NBR2 0.43 6.72 0.35 7.83e-11 Menopause (age at onset); CRC cis rs6748734 1.000 rs4311055 chr2:241821017 T/C cg16358738 chr2:241808595 AGXT -0.38 -5.8 -0.3 1.53e-8 Urinary metabolites; CRC cis rs9534288 0.699 rs2897028 chr13:46656915 C/T cg15192986 chr13:46630673 CPB2 -0.68 -8.67 -0.43 1.98e-16 Blood protein levels; CRC cis rs8072100 0.935 rs78551919 chr17:45626002 A/C cg08085267 chr17:45401833 C17orf57 0.67 10.99 0.52 3.98e-24 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs1799949 1.000 rs2292595 chr17:41290674 G/C cg01879757 chr17:41196368 BRCA1 -0.43 -6.54 -0.34 2.28e-10 Menopause (age at onset); CRC trans rs1005277 0.505 rs200939 chr10:38139483 T/C cg17830980 chr10:43048298 ZNF37B -0.41 -6.42 -0.33 4.69e-10 Extrinsic epigenetic age acceleration; CRC trans rs747782 0.527 rs3741410 chr11:48168664 A/C cg15704280 chr7:45808275 SEPT13 0.57 5.97 0.31 6.21e-9 Intraocular pressure; CRC cis rs4713118 0.869 rs7776351 chr6:27726731 A/G cg02683197 chr6:28174875 NA -0.66 -9.22 -0.45 3.54e-18 Parkinson's disease; CRC cis rs4664293 0.585 rs11893106 chr2:160540805 A/G cg08347373 chr2:160653686 CD302 0.39 6.52 0.34 2.67e-10 Monocyte percentage of white cells; CRC cis rs3751196 0.901 rs61748068 chr12:104186995 G/A cg02344784 chr12:104178138 NT5DC3 0.7 7.14 0.37 6.12e-12 Sense of smell; CRC cis rs75422866 0.510 rs73105819 chr12:48120973 C/T cg14736327 chr12:48174669 SLC48A1 -0.73 -5.92 -0.31 8e-9 Pneumonia; CRC cis rs2243480 1.000 rs34933526 chr7:65383199 A/G cg18252515 chr7:66147081 NA -1.08 -12.66 -0.57 3.44e-30 Diabetic kidney disease; CRC cis rs892961 0.899 rs312911 chr17:75414585 A/C cg05865280 chr17:75406074 SEPT9 0.65 15.16 0.64 1.01e-39 Airflow obstruction; CRC cis rs9311474 0.508 rs7652191 chr3:52610415 T/C cg11645453 chr3:52864694 ITIH4 0.35 6.3 0.33 9.46e-10 Electroencephalogram traits; CRC cis rs7937682 1.000 rs12363179 chr11:111568091 G/A cg19812747 chr11:111475976 SIK2 0.54 8.47 0.42 8.21e-16 Primary sclerosing cholangitis; CRC cis rs449789 0.524 rs3904936 chr6:159777942 G/A cg14500486 chr6:159655392 FNDC1 -0.45 -6.78 -0.35 5.65e-11 Pulse pressure; CRC cis rs2836950 0.565 rs2150414 chr21:40614988 A/G cg06238570 chr21:40685208 BRWD1 -0.64 -9.16 -0.45 5.52e-18 Menarche (age at onset); CRC cis rs2976388 0.967 rs2976393 chr8:143763618 C/G cg24046110 chr8:143859143 LYNX1 -0.36 -6.26 -0.33 1.23e-9 Urinary tract infection frequency; CRC cis rs10503871 0.685 rs7824823 chr8:30322735 G/T cg26383811 chr8:30366931 RBPMS -0.47 -7.52 -0.38 5.16e-13 Metabolite levels (X-11787); CRC cis rs769267 0.965 rs8103496 chr19:19386015 A/G cg02546618 chr19:19431379 KIAA0892;SF4 0.46 6.3 0.33 9.51e-10 Tonsillectomy; CRC trans rs916888 0.773 rs199533 chr17:44828931 G/A cg13957321 chr17:43675089 NA 0.53 6.31 0.33 8.92e-10 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC trans rs7937682 0.961 rs4935790 chr11:111633014 T/C cg18187862 chr3:45730750 SACM1L -0.53 -7.44 -0.38 8.69e-13 Primary sclerosing cholangitis; CRC cis rs79387448 0.745 rs72995652 chr2:103171651 C/A cg09003973 chr2:102972529 NA 0.73 8.01 0.4 1.97e-14 Gut microbiota (bacterial taxa); CRC cis rs6456156 0.792 rs9366089 chr6:167512896 A/G cg07513332 chr6:167530253 CCR6 0.37 5.96 0.31 6.42e-9 Primary biliary cholangitis; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg07238657 chr1:154973705 ZBTB7B 0.43 6.17 0.32 1.96e-9 Intelligence (multi-trait analysis); CRC cis rs1552244 1.000 rs2160869 chr3:10079255 G/A cg00166722 chr3:10149974 C3orf24 0.66 9.23 0.45 3.41e-18 Alzheimer's disease; CRC cis rs7937682 0.961 rs1784784 chr11:111483185 C/T cg19812747 chr11:111475976 SIK2 -0.56 -9.73 -0.47 7.59e-20 Primary sclerosing cholangitis; CRC cis rs1401999 1.000 rs939337 chr3:183701147 G/C cg05044414 chr3:183734942 ABCC5 0.48 8.33 0.42 2.22e-15 Anterior chamber depth; CRC cis rs2836974 0.897 rs34035316 chr21:40594023 T/C cg11890956 chr21:40555474 PSMG1 1.09 18.64 0.72 1.93e-53 Cognitive function; CRC cis rs1552244 0.572 rs6442154 chr3:10168785 A/G cg16606324 chr3:10149918 C3orf24 0.66 7.74 0.39 1.19e-13 Alzheimer's disease; CRC cis rs11098499 0.954 rs12508504 chr4:120410607 A/C cg09307838 chr4:120376055 NA 0.69 10.95 0.52 5.15e-24 Corneal astigmatism; CRC cis rs57994353 0.598 rs72775768 chr9:139324574 C/T cg14119001 chr9:139324193 INPP5E -0.43 -6.37 -0.33 6.49e-10 Eosinophil counts;Cutaneous squamous cell carcinoma; CRC cis rs7909074 1.000 rs7909074 chr10:45395839 G/A cg04218760 chr10:45406644 TMEM72 -0.36 -10.44 -0.5 3.11e-22 Mean corpuscular volume; CRC cis rs2952156 0.920 rs2517953 chr17:37841211 G/C cg11212589 chr17:38028394 ZPBP2 0.35 6.17 0.32 2e-9 Asthma; CRC cis rs9486719 0.843 rs3860229 chr6:97036559 T/C cg06623918 chr6:96969491 KIAA0776 -0.82 -11.38 -0.53 1.57e-25 Migraine;Coronary artery disease; CRC cis rs2243480 1.000 rs1499614 chr7:65730798 A/T cg25985355 chr7:65971099 NA -0.53 -6.02 -0.31 4.7e-9 Diabetic kidney disease; CRC cis rs9303401 0.659 rs61291849 chr17:56909867 T/C cg02118635 chr17:56770003 RAD51C;TEX14 0.78 9.95 0.48 1.51e-20 Cognitive test performance; CRC cis rs1862618 0.671 rs2591958 chr5:56239369 C/G cg20203395 chr5:56204925 C5orf35 0.57 7.96 0.4 2.91e-14 Initial pursuit acceleration; CRC cis rs9818758 0.607 rs9837237 chr3:49215583 G/T cg07636037 chr3:49044803 WDR6 -0.67 -5.8 -0.3 1.53e-8 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; CRC cis rs72781680 1.000 rs17711825 chr2:24124578 A/G cg08917208 chr2:24149416 ATAD2B 0.87 8.74 0.43 1.17e-16 Lymphocyte counts; CRC trans rs7613875 0.620 rs3774734 chr3:50108792 C/A cg21665057 chr3:196295764 WDR53;FBXO45 -0.44 -6.34 -0.33 7.37e-10 Body mass index; CRC cis rs7712401 0.755 rs10071705 chr5:122132725 T/C cg18764291 chr5:122110994 SNX2 0.42 6.76 0.35 6.39e-11 Mean platelet volume; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg19850565 chr19:35168394 ZNF302 0.47 6.36 0.33 6.86e-10 Thyroid stimulating hormone; CRC cis rs1691799 0.836 rs1168334 chr12:66760972 A/G cg16791601 chr12:66731901 HELB -0.72 -12.62 -0.57 4.62e-30 White blood cell count (basophil); CRC cis rs12497850 0.897 rs6781790 chr3:49044767 C/T cg07636037 chr3:49044803 WDR6 1.05 19.09 0.72 3.29e-55 Parkinson's disease; CRC cis rs9818758 0.607 rs9855123 chr3:49229457 C/T cg07636037 chr3:49044803 WDR6 -0.67 -5.8 -0.3 1.59e-8 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; CRC cis rs2898681 0.618 rs116241740 chr4:53733523 A/G cg00791764 chr4:53727839 RASL11B 0.57 6.09 0.32 3.09e-9 Optic nerve measurement (cup area); CRC cis rs11031096 0.542 rs10835390 chr11:3981488 A/G cg18678763 chr11:4115507 RRM1 -0.39 -6.72 -0.35 7.82e-11 Mean corpuscular volume;Mean corpuscular hemoglobin; CRC cis rs4862750 0.794 rs7692427 chr4:187901727 G/A cg06074448 chr4:187884817 NA -0.6 -11.3 -0.53 2.95e-25 Lobe attachment (rater-scored or self-reported); CRC trans rs7618501 0.933 rs1128535 chr3:49866392 C/T cg21659725 chr3:3221576 CRBN 0.91 17.77 0.7 5.22e-50 Intelligence (multi-trait analysis); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg04456666 chr15:40615783 NA 0.37 6.04 0.32 4.08e-9 Liver disease severity in Alagille syndrome; CRC cis rs3749237 0.595 rs7621003 chr3:49411404 T/C cg02487422 chr3:49467188 NICN1 0.42 6.89 0.35 2.9100000000000002e-11 Resting heart rate; CRC cis rs4478858 0.735 rs4531329 chr1:31817810 A/T cg00250761 chr1:31883323 NA -0.44 -8.5 -0.42 6.71e-16 Alcohol dependence; CRC cis rs4713118 0.539 rs200967 chr6:27862127 A/G cg02683197 chr6:28174875 NA 0.7 9.66 0.47 1.31e-19 Parkinson's disease; CRC cis rs1801251 0.752 rs2592126 chr2:233751377 A/G cg25237894 chr2:233734115 C2orf82 -0.62 -10.58 -0.5 1.07e-22 Coronary artery disease; CRC cis rs9682041 0.736 rs34237232 chr3:170063753 C/T cg11886554 chr3:170076028 SKIL -0.93 -9.46 -0.46 5.98e-19 Glomerular filtration rate in non diabetics (creatinine);Glomerular filtration rate (creatinine); CRC cis rs1448094 0.545 rs11117077 chr12:86277317 A/G cg19622623 chr12:86230825 RASSF9 -0.39 -6.19 -0.32 1.77e-9 Major depressive disorder; CRC cis rs877282 0.786 rs10904558 chr10:797509 C/T cg06581033 chr10:766294 NA -0.51 -5.77 -0.3 1.88e-8 Uric acid levels; CRC cis rs2179367 0.920 rs638407 chr6:149738350 A/G cg07828024 chr6:149772892 ZC3H12D -0.38 -6.05 -0.32 4.05e-9 Dupuytren's disease; CRC cis rs4332037 0.539 rs11762636 chr7:2061111 C/A cg23422044 chr7:1970798 MAD1L1 -0.55 -6.68 -0.35 1.04e-10 Bipolar disorder; CRC cis rs6502050 0.835 rs34960918 chr17:80113925 A/G cg11859384 chr17:80120422 CCDC57 -0.37 -5.85 -0.31 1.16e-8 Life satisfaction; CRC cis rs7727544 0.735 rs272842 chr5:131656517 A/G cg24060327 chr5:131705240 SLC22A5 -0.39 -6.38 -0.33 6.03e-10 Blood metabolite levels; CRC cis rs736408 0.521 rs13074853 chr3:52779801 T/C cg05573699 chr3:52720067 GNL3;PBRM1 -0.47 -6.83 -0.35 3.99e-11 Bipolar disorder; CRC cis rs10504229 0.683 rs11781690 chr8:58132931 C/G cg24829409 chr8:58192753 C8orf71 -0.55 -8.03 -0.4 1.71e-14 Developmental language disorder (linguistic errors); CRC cis rs11098499 0.615 rs59867181 chr4:120556467 C/T cg09307838 chr4:120376055 NA -0.59 -9.24 -0.45 3.23e-18 Corneal astigmatism; CRC cis rs10791097 0.694 rs7106684 chr11:130758153 A/T cg12179176 chr11:130786555 SNX19 0.77 12.62 0.57 4.9e-30 Autism spectrum disorder or schizophrenia;Schizophrenia; CRC cis rs4862750 0.957 rs2375916 chr4:187903923 A/G cg06074448 chr4:187884817 NA -0.62 -11.3 -0.53 3.03e-25 Lobe attachment (rater-scored or self-reported); CRC cis rs2749592 0.550 rs9733309 chr10:37882405 G/A cg00409905 chr10:38381863 ZNF37A 0.58 9.35 0.46 1.41e-18 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs3849570 0.673 rs9877408 chr3:81974558 A/G cg07356753 chr3:81810745 GBE1 -0.47 -6.43 -0.33 4.52e-10 Waist circumference;Body mass index; CRC cis rs7666738 0.791 rs12233867 chr4:98950233 A/G cg05340658 chr4:99064831 C4orf37 0.61 9.54 0.47 3.45e-19 Colonoscopy-negative controls vs population controls; CRC cis rs10751667 0.643 rs10902244 chr11:949981 A/G cg23136738 chr11:925521 AP2A2 -0.4 -6.56 -0.34 2.04e-10 Alzheimer's disease (late onset); CRC trans rs11098499 0.820 rs28535956 chr4:120536858 C/T cg25214090 chr10:38739885 LOC399744 -0.65 -10.27 -0.49 1.16e-21 Corneal astigmatism; CRC cis rs1150668 0.796 rs1124132 chr6:28380321 T/G cg12273811 chr6:28175739 NA 0.4 5.97 0.31 6.21e-9 Pubertal anthropometrics; CRC cis rs2249625 0.545 rs10498880 chr6:72882183 G/T cg18830697 chr6:72922368 RIMS1 0.41 8.01 0.4 2.02e-14 Acute urticaria and angioedema (non-steroidal anti-inflammatory drug-induced); CRC cis rs265548 0.646 rs36692 chr19:17906839 C/T cg16024904 chr19:17905718 B3GNT3 0.39 6.1 0.32 2.92e-9 Tumor biomarkers; CRC cis rs7654585 1.000 rs4692025 chr4:25949759 A/C cg10409131 chr4:25915609 C4orf52 -0.46 -6.4 -0.33 5.5e-10 Obesity-related traits; CRC cis rs4925386 0.759 rs2427293 chr20:60925859 A/G cg15193198 chr20:60906057 LAMA5 0.41 6.19 0.32 1.8e-9 Colorectal cancer;Colorectal cancer (SNP x SNP interaction); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg24796471 chr19:6737389 GPR108 0.42 6.41 0.33 5.18e-10 Liver disease severity in Alagille syndrome; CRC cis rs1167827 0.680 rs1167796 chr7:75173180 C/T cg16384552 chr7:74938386 SPDYE8P 0.45 6.55 0.34 2.16e-10 Body mass index;BMI (adjusted for smoking behaviour);BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs916888 0.779 rs199528 chr17:44843136 C/T cg17911788 chr17:44343683 NA -0.66 -7.27 -0.37 2.69e-12 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs13256369 0.826 rs12678414 chr8:8586016 G/T cg06636001 chr8:8085503 FLJ10661 0.49 6.39 0.33 5.69e-10 Obesity-related traits; CRC cis rs9322193 0.923 rs11155677 chr6:150078089 C/G cg05861140 chr6:150128134 PCMT1 -0.39 -6.26 -0.33 1.21e-9 Lung cancer; CRC cis rs12618769 0.652 rs2230388 chr2:99193496 C/T cg18455616 chr2:99124870 INPP4A 0.36 5.91 0.31 8.57e-9 Bipolar disorder; CRC cis rs9457247 0.935 rs2757046 chr6:167374353 C/T cg23791538 chr6:167370224 RNASET2 0.39 6.07 0.32 3.46e-9 Crohn's disease; CRC cis rs6712932 0.962 rs2053241 chr2:105842228 G/A cg27422857 chr2:105853526 NA -0.38 -6.99 -0.36 1.55e-11 Type 2 diabetes; CRC cis rs11031096 0.563 rs12281849 chr11:4224832 C/T cg18678763 chr11:4115507 RRM1 -0.38 -6.16 -0.32 2.07e-9 Mean corpuscular volume;Mean corpuscular hemoglobin; CRC trans rs875971 0.545 rs73142265 chr7:65699497 G/A cg02869306 chr7:64672164 INTS4L1 -0.43 -6.16 -0.32 2.07e-9 Aortic root size; CRC cis rs79349575 0.729 rs62075824 chr17:46986679 A/G cg00947319 chr17:47005597 UBE2Z -0.34 -5.88 -0.31 1.02e-8 Type 2 diabetes; CRC cis rs4474465 1.000 rs10899525 chr11:78201454 T/G cg27205649 chr11:78285834 NARS2 -0.47 -5.79 -0.3 1.61e-8 Alzheimer's disease (survival time); CRC cis rs9322193 0.923 rs9505826 chr6:149955048 A/G cg05861140 chr6:150128134 PCMT1 -0.36 -5.92 -0.31 8.26e-9 Lung cancer; CRC cis rs4713118 0.824 rs9366702 chr6:27734470 T/C cg26587870 chr6:27730563 NA -0.47 -6.99 -0.36 1.53e-11 Parkinson's disease; CRC cis rs7615952 0.599 rs66532274 chr3:125731845 G/A cg02772935 chr3:125709198 NA -0.46 -5.94 -0.31 7.44e-9 Blood pressure (smoking interaction); CRC cis rs2239547 0.563 rs4302374 chr3:52905802 T/C cg10802521 chr3:52805072 NEK4 -0.47 -6.4 -0.33 5.37e-10 Schizophrenia; CRC cis rs7605827 0.930 rs12692263 chr2:15539206 G/A cg19274914 chr2:15703543 NA 0.4 5.94 0.31 7.2e-9 Educational attainment (years of education); CRC cis rs2404602 0.647 rs4886840 chr15:77179002 A/G cg23625390 chr15:77176239 SCAPER -0.86 -13.61 -0.6 9.01e-34 Blood metabolite levels; CRC cis rs1881797 1.000 rs12081895 chr1:247686666 C/G cg11166453 chr1:247681781 NA 0.43 7.0 0.36 1.48e-11 Acute lymphoblastic leukemia (childhood); CRC cis rs7113874 0.524 rs10743076 chr11:8560571 C/A cg02811074 chr11:8615871 STK33 -0.36 -6.09 -0.32 3.13e-9 Body mass index in physically active individuals;Body mass index (joint analysis main effects and physical activity interaction); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg08417425 chr5:153784856 GALNT10 0.37 6.2 0.32 1.69e-9 Liver disease severity in Alagille syndrome; CRC cis rs7666738 0.830 rs35951881 chr4:98999474 A/C cg17366294 chr4:99064904 C4orf37 0.44 7.39 0.38 1.19e-12 Colonoscopy-negative controls vs population controls; CRC cis rs1552244 1.000 rs7615646 chr3:10089773 A/C cg16606324 chr3:10149918 C3orf24 0.72 9.82 0.48 3.92e-20 Alzheimer's disease; CRC trans rs17685 0.712 rs7794454 chr7:75776010 A/G cg19862616 chr7:65841803 NCRNA00174 -0.96 -17.49 -0.69 7.06e-49 Coffee consumption;Coffee consumption (cups per day); CRC cis rs1005277 0.505 rs13503 chr10:38239843 C/A cg25517755 chr10:38738941 LOC399744 0.45 6.56 0.34 2.07e-10 Extrinsic epigenetic age acceleration; CRC cis rs10870270 0.957 rs7074604 chr10:133740373 G/C cg08754478 chr10:133766260 PPP2R2D -0.65 -9.42 -0.46 8.28e-19 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; CRC cis rs7613875 0.620 rs34312088 chr3:50032133 C/T cg05623727 chr3:50126028 RBM5 0.6 10.52 0.5 1.68e-22 Body mass index; CRC cis rs2066819 1.000 rs41363748 chr12:56696056 C/T cg26714650 chr12:56694279 CS 1.29 10.83 0.51 1.4e-23 Psoriasis vulgaris; CRC cis rs9467711 0.516 rs1177441 chr6:25859413 A/G cg08501292 chr6:25962987 TRIM38 0.64 6.68 0.35 1.04e-10 Autism spectrum disorder or schizophrenia; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg06052471 chr11:61130074 TMEM138;CYBASC3 0.48 6.76 0.35 6.33e-11 Response to antipsychotic treatment; CRC cis rs7605378 0.528 rs1704190 chr2:200760629 G/A cg23649088 chr2:200775458 C2orf69 0.72 11.71 0.54 1.05e-26 Osteoporosis; CRC cis rs2050392 0.760 rs10826797 chr10:30690376 A/C cg25182066 chr10:30743637 MAP3K8 -0.48 -6.71 -0.35 8.61e-11 Inflammatory bowel disease; CRC cis rs10870270 1.000 rs7078692 chr10:133775370 T/A cg17892150 chr10:133769511 PPP2R2D -0.74 -10.89 -0.51 8.4e-24 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; CRC cis rs6951245 0.572 rs73264010 chr7:1040477 T/C cg20603222 chr7:1096387 C7orf50;GPR146 -0.64 -5.81 -0.3 1.49e-8 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs6570726 0.791 rs9403729 chr6:145907007 C/T cg13319975 chr6:146136371 FBXO30 -0.45 -6.64 -0.34 1.3e-10 Lobe attachment (rater-scored or self-reported); CRC cis rs1448094 0.511 rs61930585 chr12:86158461 C/A cg00310523 chr12:86230176 RASSF9 0.42 6.69 0.35 9.85e-11 Major depressive disorder; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg15716185 chr18:60190644 ZCCHC2 0.4 5.99 0.31 5.52e-9 Intelligence (multi-trait analysis); CRC cis rs4654899 0.897 rs7548649 chr1:21090081 A/G cg02927042 chr1:21476669 EIF4G3 -0.43 -6.67 -0.35 1.1e-10 Superior frontal gyrus grey matter volume; CRC cis rs2243480 1.000 rs1723267 chr7:65473314 G/A cg18252515 chr7:66147081 NA -1.06 -12.35 -0.56 4.92e-29 Diabetic kidney disease; CRC cis rs801193 0.844 rs732465 chr7:65998450 T/C cg18876405 chr7:65276391 NA 0.59 10.53 0.5 1.57e-22 Aortic root size; CRC cis rs11098499 0.739 rs9884728 chr4:120127079 C/T cg09307838 chr4:120376055 NA -0.53 -8.24 -0.41 4.06e-15 Corneal astigmatism; CRC cis rs7605827 0.897 rs10084390 chr2:15597662 C/A cg19274914 chr2:15703543 NA 0.39 6.03 0.32 4.51e-9 Educational attainment (years of education); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg03383661 chr6:42714115 TBCC 0.44 6.27 0.33 1.14e-9 Response to antipsychotic treatment; CRC cis rs2952156 0.920 rs9303274 chr17:37836353 T/C cg07936489 chr17:37558343 FBXL20 -0.45 -6.47 -0.34 3.48e-10 Asthma; CRC cis rs4713118 0.955 rs9468201 chr6:27687035 C/T cg15786705 chr6:28176104 NA 0.48 6.39 0.33 5.74e-10 Parkinson's disease; CRC cis rs10504229 0.775 rs56082079 chr8:58163732 T/C cg11062466 chr8:58055876 NA 0.45 5.82 0.31 1.39e-8 Developmental language disorder (linguistic errors); CRC cis rs16867321 0.951 rs61289394 chr2:181354915 T/G cg23363182 chr2:181467187 NA -0.48 -5.89 -0.31 9.54e-9 Obesity; CRC cis rs11098499 0.954 rs13107475 chr4:120393011 A/T cg24375607 chr4:120327624 NA 0.49 7.62 0.39 2.72e-13 Corneal astigmatism; CRC cis rs2730245 0.527 rs2527197 chr7:158735260 G/A cg24397884 chr7:158709396 WDR60 -0.99 -11.95 -0.55 1.37e-27 Height; CRC cis rs7662987 0.517 rs2602881 chr4:100040695 A/G cg13256891 chr4:100009986 ADH5 0.63 8.54 0.43 4.99e-16 Smoking initiation; CRC cis rs2014572 0.967 rs8112572 chr19:57759612 T/C cg12963866 chr19:57752005 ZNF805 -0.42 -6.22 -0.32 1.5e-9 Hyperactive-impulsive symptoms; CRC cis rs9549328 0.700 rs4907570 chr13:113617651 T/C cg25790453 chr13:113633590 MCF2L 0.44 7.65 0.39 2.22e-13 Systolic blood pressure; CRC cis rs477895 0.713 rs882146 chr11:63976699 G/A cg18225595 chr11:63971243 STIP1 0.6 7.74 0.39 1.23e-13 Mean platelet volume; CRC cis rs4803468 1.000 rs10422783 chr19:41906436 T/C cg09537434 chr19:41945824 ATP5SL -0.97 -18.74 -0.72 7.61e-54 Height; CRC cis rs4819052 0.851 rs28501512 chr21:46676702 C/T cg11663144 chr21:46675770 NA -0.83 -14.25 -0.62 3.35e-36 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs7085104 0.700 rs7096183 chr10:104609466 T/C cg15744005 chr10:104629667 AS3MT -0.36 -7.7 -0.39 1.61e-13 Immature fraction of reticulocytes;Schizophrenia; CRC cis rs3806843 0.576 rs155359 chr5:140315425 G/T cg19875535 chr5:140030758 IK 0.42 6.5 0.34 3.04e-10 Depressive symptoms (multi-trait analysis); CRC cis rs9443645 0.527 rs10943588 chr6:79510994 A/C cg09184832 chr6:79620586 NA -0.44 -7.49 -0.38 6.26e-13 Intelligence (multi-trait analysis); CRC cis rs853679 0.517 rs4711164 chr6:28115156 C/T cg15786705 chr6:28176104 NA 0.78 9.83 0.48 3.57e-20 Depression; CRC cis rs6938 0.534 rs12907898 chr15:75207872 C/T cg14664628 chr15:75095509 CSK -0.64 -9.9 -0.48 2.21e-20 Breast cancer; CRC trans rs3733585 0.673 rs6850143 chr4:9958924 T/C cg26043149 chr18:55253948 FECH -0.5 -7.62 -0.39 2.81e-13 Cleft plate (environmental tobacco smoke interaction); CRC cis rs344364 0.602 rs7188401 chr16:1876949 G/C cg09830162 chr16:1889614 FAHD1;C16orf73 -0.56 -8.08 -0.41 1.21e-14 Glomerular filtration rate in chronic kidney disease; CRC cis rs9311474 0.629 rs7636227 chr3:52566682 G/A cg08365687 chr3:52569147 NT5DC2;LOC440957 0.34 5.7 0.3 2.71e-8 Electroencephalogram traits; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg03669052 chr18:72164002 CNDP2 0.5 7.04 0.36 1.14e-11 Response to antipsychotic treatment; CRC cis rs40363 0.645 rs250630 chr16:3524242 C/T cg21433313 chr16:3507492 NAT15 0.57 8.33 0.42 2.29e-15 Tuberculosis; CRC cis rs801193 0.660 rs1016265 chr7:66214567 C/T cg00343986 chr7:65444356 GUSB 0.44 6.21 0.32 1.63e-9 Aortic root size; CRC cis rs6504622 1.000 rs12940071 chr17:45028052 C/T cg16759221 chr17:45003025 GOSR2 0.45 7.17 0.37 4.83e-12 Orofacial clefts; CRC cis rs954108 0.522 rs7983818 chr13:29383182 A/C cg11788234 chr13:29393811 NA -0.52 -9.13 -0.45 7.11e-18 Obesity-related traits; CRC cis rs6951245 1.000 rs79327308 chr7:1108141 A/C cg03188948 chr7:1209495 NA 0.65 6.85 0.35 3.68e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs734999 0.588 rs2764848 chr1:2530694 G/A cg20673091 chr1:2541236 MMEL1 -0.37 -6.04 -0.32 4.08e-9 Ulcerative colitis; CRC cis rs6570726 0.791 rs405206 chr6:145836873 C/A cg23711669 chr6:146136114 FBXO30 0.74 12.97 0.58 2.27e-31 Lobe attachment (rater-scored or self-reported); CRC cis rs12541335 0.639 rs11779277 chr8:22200683 C/T cg09517075 chr8:22133004 PIWIL2 0.49 8.43 0.42 1.09e-15 Hypertriglyceridemia; CRC cis rs6860806 0.507 rs635619 chr5:131720265 G/A cg18758796 chr5:131593413 PDLIM4 -0.41 -6.59 -0.34 1.8e-10 Breast cancer; CRC cis rs9462846 0.919 rs6936722 chr6:42891311 A/G cg02353165 chr6:42928485 GNMT -0.46 -6.29 -0.33 1e-9 Blood protein levels; CRC cis rs34034915 1 rs34034915 chr6:27720703 T/TG cg06470822 chr6:28175283 NA 0.64 9.21 0.45 3.97e-18 Hepatitis A; CRC cis rs4654899 0.865 rs6691824 chr1:21417577 T/G cg02927042 chr1:21476669 EIF4G3 -0.53 -8.43 -0.42 1.08e-15 Superior frontal gyrus grey matter volume; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg02854695 chr19:50832032 KCNC3 0.36 6.09 0.32 3.11e-9 Liver disease severity in Alagille syndrome; CRC cis rs7615952 0.576 rs4646748 chr3:125826329 G/A cg05084668 chr3:125655381 ALG1L -0.4 -5.73 -0.3 2.32e-8 Blood pressure (smoking interaction); CRC trans rs6703335 0.870 rs10803142 chr1:243598234 A/G cg16924120 chr12:118814149 SUDS3 0.45 6.52 0.34 2.68e-10 Schizophrenia;Schizophrenia, schizoaffective disorder or bipolar disorder; CRC cis rs2033711 0.870 rs3764534 chr19:58929136 G/A cg13877915 chr19:58951672 ZNF132 0.51 8.45 0.42 9.22e-16 Uric acid clearance; CRC trans rs2243480 1.000 rs68189316 chr7:65409169 C/G cg10756647 chr7:56101905 PSPH 0.72 7.98 0.4 2.39e-14 Diabetic kidney disease; CRC cis rs9457247 0.663 rs9459835 chr6:167417551 G/T cg23791538 chr6:167370224 RNASET2 -0.41 -6.37 -0.33 6.43e-10 Crohn's disease; CRC cis rs4665809 0.556 rs1560869 chr2:26417095 T/C cg22920501 chr2:26401640 FAM59B -0.82 -11.68 -0.54 1.37e-26 Gut microbiome composition (summer); CRC cis rs8180040 0.932 rs11712445 chr3:47434552 T/C cg27129171 chr3:47204927 SETD2 0.52 8.07 0.41 1.38e-14 Colorectal cancer; CRC cis rs12701220 0.894 rs12701348 chr7:1039457 C/T cg00990874 chr7:1149470 C7orf50 -0.54 -6.61 -0.34 1.58e-10 Bronchopulmonary dysplasia; CRC cis rs929354 0.772 rs1182362 chr7:157019535 A/G cg05182265 chr7:156933206 UBE3C 0.77 14.61 0.63 1.28e-37 Body mass index; CRC cis rs9682041 0.627 rs6786374 chr3:170105233 A/G cg11886554 chr3:170076028 SKIL -0.59 -7.42 -0.38 1.03e-12 Glomerular filtration rate in non diabetics (creatinine);Glomerular filtration rate (creatinine); CRC cis rs3087591 0.708 rs3815154 chr17:29654974 G/A cg24425628 chr17:29625626 OMG;NF1 0.71 12.7 0.57 2.34e-30 Hip circumference; CRC cis rs12983728 0.732 rs34003091 chr19:58662254 T/C cg08687515 chr19:58661962 ZNF329 0.8 8.74 0.43 1.23e-16 Cholesterol, total; CRC cis rs6831352 0.879 rs56272995 chr4:100060882 A/G cg12011299 chr4:100065546 ADH4 -0.5 -9.53 -0.47 3.62e-19 Alcohol dependence; CRC cis rs28386778 0.897 rs894407 chr17:61901641 T/C cg11494091 chr17:61959527 GH2 0.6 10.1 0.49 4.51e-21 Prudent dietary pattern; CRC trans rs9341835 0.772 rs9294206 chr6:64141201 A/G cg13657004 chr13:50234944 EBPL -0.36 -6.06 -0.32 3.78e-9 Schizophrenia; CRC cis rs4728302 0.838 rs2042453 chr7:133580730 G/A cg10665199 chr7:133106180 EXOC4 0.4 5.99 0.31 5.51e-9 Intelligence;Intelligence (multi-trait analysis); CRC cis rs4547160 0.962 rs12229749 chr12:63503447 C/T cg26727693 chr12:63544175 AVPR1A -0.4 -7.87 -0.4 5.28e-14 Morning vs. evening chronotype; CRC cis rs875971 0.660 rs10272357 chr7:66063074 G/A cg25985355 chr7:65971099 NA 0.32 5.7 0.3 2.62e-8 Aortic root size; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg18788524 chr1:145096602 SEC22B 0.39 6.4 0.33 5.5e-10 Liver disease severity in Alagille syndrome; CRC trans rs11098499 0.954 rs4309825 chr4:120314881 C/T cg25214090 chr10:38739885 LOC399744 -0.62 -9.61 -0.47 1.92e-19 Corneal astigmatism; CRC cis rs4910157 1 rs4910157 chr11:8941215 A/G cg12365402 chr11:9010492 NRIP3 0.5 8.43 0.42 1.08e-15 Tonsillectomy; CRC cis rs72945132 0.882 rs12295111 chr11:70131882 C/A cg00319359 chr11:70116639 PPFIA1 0.67 7.4 0.38 1.13e-12 Coronary artery disease; CRC cis rs2953145 0.545 rs2975755 chr2:241524919 G/A cg07929629 chr2:241523174 NA 0.65 9.92 0.48 1.87e-20 Bipolar disorder; CRC cis rs12200560 0.505 rs60879781 chr6:97075466 A/T cg06623918 chr6:96969491 KIAA0776 0.52 7.76 0.39 1.08e-13 Coronary heart disease; CRC cis rs9479482 1.000 rs11155697 chr6:150357423 C/T cg25797454 chr6:150327115 RAET1K 0.38 6.51 0.34 2.8e-10 Alopecia areata; CRC cis rs4713118 0.955 rs9468201 chr6:27687035 C/T cg26587870 chr6:27730563 NA -0.42 -6.3 -0.33 9.41e-10 Parkinson's disease; CRC cis rs9910055 1.000 rs9895423 chr17:42285740 T/C cg13607699 chr17:42295918 UBTF 0.6 8.46 0.42 8.73e-16 Total body bone mineral density; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg01584448 chr16:50099761 HEATR3 0.44 7.06 0.36 1e-11 Liver disease severity in Alagille syndrome; CRC cis rs10197940 0.686 rs12616688 chr2:152242099 C/G cg19508488 chr2:152266495 RIF1 0.6 8.7 0.43 1.65e-16 Lung cancer; CRC cis rs6582630 0.555 rs2004152 chr12:38478951 C/T cg26384229 chr12:38710491 ALG10B 0.71 9.52 0.46 3.81e-19 Drug-induced liver injury (flucloxacillin); CRC cis rs12791968 0.649 rs3802785 chr11:44995441 C/T cg11846598 chr11:44996168 LOC221122 -0.5 -6.92 -0.36 2.41e-11 Inhibitory control; CRC cis rs9329289 0.603 rs2458705 chr10:2541377 A/G cg15501526 chr10:2543763 NA 0.68 13.18 0.59 3.99e-32 Age-related hearing impairment; CRC cis rs7932354 0.528 rs1965952 chr11:47181040 G/A cg03339077 chr11:47165057 C11orf49 -0.46 -6.28 -0.33 1.06e-9 Bone mineral density (hip);Bone mineral density; CRC trans rs12478296 0.792 rs6755390 chr2:243012998 C/T cg06834434 chr14:75079333 LTBP2 0.52 6.03 0.32 4.31e-9 Obesity-related traits; CRC cis rs7680126 0.632 rs78030862 chr4:10150412 G/A cg11266682 chr4:10021025 SLC2A9 -0.42 -6.16 -0.32 2.15e-9 Urate levels in lean individuals;Urate levels in overweight individuals;Urate levels in obese individuals; CRC cis rs7680126 0.633 rs4698040 chr4:10352550 C/T cg11266682 chr4:10021025 SLC2A9 -0.43 -6.36 -0.33 6.74e-10 Urate levels in lean individuals;Urate levels in overweight individuals;Urate levels in obese individuals; CRC cis rs1552244 1.000 rs28684871 chr3:10072635 C/A cg02579736 chr3:10068473 FANCD2;CIDECP 0.94 12.39 0.56 3.38e-29 Alzheimer's disease; CRC cis rs282587 0.569 rs7987238 chr13:113409944 G/A cg04656015 chr13:113407548 ATP11A 0.65 8.12 0.41 9.52e-15 Glycated hemoglobin levels; CRC cis rs11031096 0.754 rs3817657 chr11:4142592 T/C cg18678763 chr11:4115507 RRM1 -0.43 -7.32 -0.37 1.86e-12 Mean corpuscular volume;Mean corpuscular hemoglobin; CRC cis rs1552244 0.882 rs36006511 chr3:10054191 C/T cg02579736 chr3:10068473 FANCD2;CIDECP 0.99 12.66 0.57 3.33e-30 Alzheimer's disease; CRC cis rs853679 0.517 rs9393887 chr6:28059020 G/A cg15786705 chr6:28176104 NA 0.74 9.43 0.46 7.64e-19 Depression; CRC cis rs780096 0.506 rs1647265 chr2:27692261 A/G cg02592271 chr2:27665507 KRTCAP3 -0.28 -6.58 -0.34 1.83e-10 Total body bone mineral density; CRC cis rs12142240 0.698 rs17361805 chr1:46813967 C/T cg14993813 chr1:46806288 NSUN4 -0.52 -6.53 -0.34 2.42e-10 Menopause (age at onset); CRC cis rs853679 0.517 rs9393896 chr6:28127703 C/T cg23161317 chr6:28129485 ZNF389 0.53 6.43 0.33 4.52e-10 Depression; CRC trans rs10982213 0.830 rs2274163 chr9:117188714 C/T cg15617548 chr2:171785815 GORASP2 0.45 6.97 0.36 1.72e-11 Interleukin-6 levels; CRC cis rs807669 0.548 rs5746685 chr22:19192596 C/G cg02655711 chr22:19163373 SLC25A1 -0.76 -13.35 -0.59 9.04e-33 Metabolite levels; CRC cis rs9287719 0.601 rs10084172 chr2:10771228 A/C cg00105475 chr2:10696890 NA 0.46 7.06 0.36 1.02e-11 Prostate cancer; CRC cis rs3858526 0.959 rs4758219 chr11:5951846 G/C cg13902645 chr11:5959945 NA -0.64 -9.0 -0.44 1.81e-17 DNA methylation (variation); CRC cis rs9902453 0.967 rs12449783 chr17:28527653 A/C cg26525008 chr17:28256777 EFCAB5;SSH2 0.57 8.55 0.43 4.76e-16 Coffee consumption (cups per day); CRC cis rs875971 0.755 rs10228885 chr7:65780529 C/G cg18876405 chr7:65276391 NA -0.53 -8.59 -0.43 3.44e-16 Aortic root size; CRC trans rs1353394 0.617 rs11129904 chr3:41465657 A/G cg08437403 chr11:1669832 HCCA2 -0.44 -6.09 -0.32 3.2e-9 Gut microbiota (functional units); CRC cis rs172166 0.694 rs536704 chr6:28092603 T/G cg15845792 chr6:28175446 NA 0.77 11.42 0.53 1.13e-25 Cardiac Troponin-T levels; CRC cis rs2032447 0.798 rs807212 chr6:26065621 A/G cg27635394 chr6:26043820 HIST1H2BB 0.44 6.42 0.33 4.63e-10 Intelligence (multi-trait analysis); CRC trans rs9388451 0.869 rs7764016 chr6:126070789 T/G cg05039488 chr6:79577232 IRAK1BP1 -0.59 -9.1 -0.45 8.67e-18 Brugada syndrome; CRC cis rs4927850 0.958 rs1975582 chr3:195751439 G/T cg00031303 chr3:195681400 NA 0.5 7.2 0.37 4.16e-12 Pancreatic cancer; CRC cis rs881375 0.967 rs1930781 chr9:123687834 G/A cg09586646 chr9:123605570 PSMD5;LOC253039 0.47 6.53 0.34 2.5e-10 Rheumatoid arthritis; CRC cis rs208520 0.690 rs207112 chr6:66792092 C/T cg07460842 chr6:66804631 NA -1.09 -15.38 -0.65 1.37e-40 Exhaled nitric oxide output; CRC cis rs4819052 0.851 rs12626188 chr21:46669258 A/G cg11663144 chr21:46675770 NA -0.84 -14.43 -0.62 6.81e-37 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs4862750 0.872 rs6811837 chr4:187898162 G/A cg11301795 chr4:187892539 NA -0.87 -19.82 -0.74 4.43e-58 Lobe attachment (rater-scored or self-reported); CRC cis rs8105895 0.935 rs7247147 chr19:22249858 G/C cg02657401 chr19:22469223 NA -0.34 -5.65 -0.3 3.56e-8 Body mass index (change over time); CRC cis rs3087591 0.600 rs2952975 chr17:29490992 A/G cg24425628 chr17:29625626 OMG;NF1 0.66 8.58 0.43 3.9e-16 Hip circumference; CRC cis rs3806843 1.000 rs7701755 chr5:140182101 G/T cg19875535 chr5:140030758 IK 0.63 10.26 0.49 1.26e-21 Depressive symptoms (multi-trait analysis); CRC cis rs9611565 0.625 rs9607819 chr22:41958862 C/G cg06634786 chr22:41940651 POLR3H -0.6 -6.94 -0.36 2.09e-11 Vitiligo; CRC trans rs12189452 0.507 rs4957723 chr5:107157011 C/T cg09163005 chr12:14926986 H2AFJ 0.39 6.1 0.32 2.91e-9 Intelligence (multi-trait analysis); CRC cis rs6988636 0.901 rs16898076 chr8:124187721 T/C cg27053337 chr8:124217698 FAM83A 0.45 6.82 0.35 4.48e-11 Urinary uromodulin levels; CRC cis rs9916302 0.904 rs801426 chr17:37441109 C/T cg00129232 chr17:37814104 STARD3 0.53 7.89 0.4 4.39e-14 Glomerular filtration rate (creatinine); CRC cis rs7705042 0.865 rs7723666 chr5:141513966 C/T cg08523384 chr5:141488047 NDFIP1 -0.32 -5.66 -0.3 3.24e-8 Asthma; CRC cis rs7614311 0.552 rs73117078 chr3:63942084 G/A cg22134162 chr3:63841271 THOC7 -0.57 -5.76 -0.3 1.89e-8 Lung function (FVC);Lung function (FEV1); CRC cis rs34779708 0.931 rs4934719 chr10:35376769 T/C cg03585969 chr10:35415529 CREM 0.66 8.8 0.44 7.85e-17 Inflammatory bowel disease;Crohn's disease; CRC trans rs2430386 1.000 rs2430386 chr2:63178111 C/T cg05376469 chr2:102649931 NA -0.37 -6.28 -0.33 1.04e-9 Prostate cancer; CRC cis rs8060686 0.920 rs12448923 chr16:67839128 C/T cg08314208 chr16:67682810 RLTPR -0.65 -7.41 -0.38 1.08e-12 HDL cholesterol;Metabolic syndrome; CRC cis rs897984 0.721 rs28360557 chr16:30983260 A/C cg00531865 chr16:30841666 NA 0.47 6.78 0.35 5.6e-11 Dementia with Lewy bodies; CRC cis rs3772130 0.962 rs6776670 chr3:121543120 C/T cg20356878 chr3:121714668 ILDR1 0.5 7.87 0.4 5.23e-14 Cognitive performance; CRC cis rs7615952 0.932 rs13065725 chr3:125632289 C/A cg05084668 chr3:125655381 ALG1L -0.62 -8.37 -0.42 1.71e-15 Blood pressure (smoking interaction); CRC cis rs7666738 0.830 rs12233741 chr4:98950296 C/T cg17366294 chr4:99064904 C4orf37 0.43 7.34 0.38 1.69e-12 Colonoscopy-negative controls vs population controls; CRC cis rs7264396 0.887 rs6060442 chr20:34093757 C/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.4 -6.62 -0.34 1.44e-10 Total cholesterol levels; CRC cis rs916888 0.697 rs199516 chr17:44856485 C/T cg01570182 chr17:44337453 NA -1.07 -12.71 -0.57 2.22e-30 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs2836974 0.897 rs6517513 chr21:40526878 A/G cg11890956 chr21:40555474 PSMG1 1.1 21.14 0.76 3.07e-63 Cognitive function; CRC cis rs9611519 1.000 rs2057070 chr22:41564287 T/C cg03806693 chr22:41940476 POLR3H -0.56 -7.17 -0.37 4.95e-12 Neuroticism; CRC cis rs7917772 0.503 rs10748825 chr10:104293609 A/G cg22532475 chr10:104410764 TRIM8 -0.36 -6.8 -0.35 5.08e-11 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC cis rs7113874 0.550 rs11042002 chr11:8616646 T/C cg17679104 chr11:8615758 STK33 0.38 6.41 0.33 5.17e-10 Body mass index in physically active individuals;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs11098499 0.955 rs1511015 chr4:120170473 A/C cg09307838 chr4:120376055 NA 0.61 9.47 0.46 5.44e-19 Corneal astigmatism; CRC cis rs769267 0.965 rs735273 chr19:19385411 T/C cg01262667 chr19:19385393 TM6SF2 0.36 5.85 0.31 1.16e-8 Tonsillectomy; CRC cis rs8070740 1.000 rs8080400 chr17:5328633 G/A cg25236894 chr17:5323110 RPAIN;NUP88 0.48 6.98 0.36 1.65e-11 Menopause (age at onset); CRC cis rs2243480 1.000 rs35391607 chr7:65360829 G/A cg12463550 chr7:65579703 CRCP 0.66 6.14 0.32 2.36e-9 Diabetic kidney disease; CRC cis rs17234274 0.644 rs10833970 chr11:23219417 A/G cg05245346 chr11:23248277 NA 0.36 5.92 0.31 8.22e-9 Cancer; CRC cis rs10878977 0.542 rs11177662 chr12:69818480 C/T cg20891283 chr12:69753455 YEATS4 -0.58 -5.65 -0.3 3.4e-8 Colorectal cancer; CRC cis rs3106136 0.872 rs13130583 chr4:95245543 T/C cg11021082 chr4:95130006 SMARCAD1 0.42 6.45 0.34 3.93e-10 Capecitabine sensitivity; CRC cis rs4665809 0.531 rs3892649 chr2:26457267 T/G cg27170947 chr2:26402098 FAM59B 0.6 7.82 0.4 7.45e-14 Gut microbiome composition (summer); CRC cis rs3733585 0.673 rs7434391 chr4:9967682 C/G cg00071950 chr4:10020882 SLC2A9 -0.55 -9.72 -0.47 8.53e-20 Cleft plate (environmental tobacco smoke interaction); CRC cis rs896854 0.967 rs13257021 chr8:95965695 A/G cg09323728 chr8:95962352 TP53INP1 -0.44 -7.25 -0.37 2.92e-12 Type 2 diabetes; CRC cis rs12410462 1.000 rs76233861 chr1:227673909 G/A cg04117972 chr1:227635322 NA 0.6 6.51 0.34 2.82e-10 Major depressive disorder; CRC cis rs801193 1.000 rs10252765 chr7:66228732 C/G cg18876405 chr7:65276391 NA 0.59 10.16 0.49 2.9e-21 Aortic root size; CRC cis rs11212617 1.000 rs227093 chr11:108233939 T/A cg01991180 chr11:108092276 ATM;NPAT 0.41 6.03 0.32 4.32e-9 Response to metformin in type 2 diabetes (glycemic); CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg16143763 chr17:41116517 AARSD1 -0.38 -6.01 -0.31 4.81e-9 Myopia (pathological); CRC cis rs9467711 0.606 rs9358932 chr6:26362705 A/G cg16898833 chr6:26189333 HIST1H4D -0.73 -6.47 -0.34 3.48e-10 Autism spectrum disorder or schizophrenia; CRC cis rs2072499 0.750 rs909269 chr1:156192028 C/T cg24450063 chr1:156163899 SLC25A44 1.08 16.82 0.68 3.12e-46 Testicular germ cell tumor; CRC cis rs9916302 0.706 rs4795375 chr17:37662932 T/C cg20243544 chr17:37824526 PNMT 0.47 5.61 0.3 4.22e-8 Glomerular filtration rate (creatinine); CRC cis rs12995491 0.731 rs17435433 chr2:88509616 A/G cg07952391 chr2:88470173 THNSL2 -0.41 -6.0 -0.31 5.12e-9 Response to metformin (IC50); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg06766273 chr11:62521983 ZBTB3 0.53 7.63 0.39 2.48e-13 Response to antipsychotic treatment; CRC cis rs2386661 0.547 rs11259582 chr10:5646767 C/T cg17085576 chr10:5658249 NA -0.43 -6.19 -0.32 1.78e-9 Breast cancer; CRC cis rs9649213 0.593 rs2240349 chr7:97984663 C/T cg00277769 chr7:97922759 BAIAP2L1 -0.6 -10.46 -0.5 2.68e-22 Prostate cancer (SNP x SNP interaction); CRC cis rs7927771 0.965 rs3817335 chr11:47643891 T/A cg20307385 chr11:47447363 PSMC3 -0.54 -7.56 -0.38 4.13e-13 Subjective well-being; CRC cis rs1580019 0.587 rs7806941 chr7:32553319 G/T cg06627557 chr7:32535165 LSM5;AVL9 0.96 18.4 0.71 1.71e-52 Cognitive ability; CRC cis rs45509595 0.841 rs9368531 chr6:27781872 G/C cg23259851 chr6:27775964 HIST1H2AI;HIST1H2BL 0.71 5.93 0.31 7.74e-9 Breast cancer; CRC cis rs60733400 0.817 rs4648657 chr1:2560735 A/G cg18854424 chr1:2615690 NA -0.4 -7.47 -0.38 7.06e-13 Multiple sclerosis; CRC cis rs72945132 0.882 rs12099016 chr11:70195161 C/G cg00319359 chr11:70116639 PPFIA1 0.55 6.07 0.32 3.52e-9 Coronary artery disease; CRC cis rs9660180 0.967 rs6664664 chr1:1751264 G/A cg17747265 chr1:1875780 NA -0.74 -12.73 -0.57 1.85e-30 Body mass index; CRC cis rs2739330 0.761 rs5760176 chr22:24402321 A/G cg11060661 chr22:24314208 DDT;DDTL -0.45 -7.85 -0.4 6.07e-14 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs10769966 0.515 rs2568069 chr11:8977707 G/A cg14711859 chr11:8959438 ASCL3 -0.58 -11.14 -0.52 1.12e-24 High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; CRC cis rs4969178 0.965 rs3744217 chr17:76400258 G/A cg05887092 chr17:76393375 PGS1 0.56 10.01 0.48 9.4e-21 HDL cholesterol levels; CRC cis rs12701220 0.894 rs8591 chr7:1036799 C/T cg02733842 chr7:1102375 C7orf50 -0.8 -10.12 -0.49 3.78e-21 Bronchopulmonary dysplasia; CRC cis rs2032447 0.507 rs199741 chr6:25931577 A/G cg03264133 chr6:25882463 NA -0.82 -11.23 -0.53 5.37e-25 Intelligence (multi-trait analysis); CRC cis rs904251 0.523 rs2797796 chr6:37480886 T/C cg25019722 chr6:37503610 NA -0.47 -8.74 -0.43 1.24e-16 Cognitive performance; CRC cis rs2692947 0.770 rs72492163 chr2:96417816 G/A cg23100626 chr2:96804247 ASTL 0.26 6.87 0.35 3.22e-11 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; CRC trans rs916888 0.610 rs199530 chr17:44836653 C/T cg10053473 chr17:62856997 LRRC37A3 0.64 9.04 0.45 1.33e-17 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC trans rs11098499 0.954 rs3733519 chr4:120423448 A/G cg25214090 chr10:38739885 LOC399744 0.65 10.02 0.48 8.79e-21 Corneal astigmatism; CRC cis rs2857891 0.909 rs56026267 chr11:6940211 T/C cg17084751 chr11:6953558 ZNF215 -0.51 -5.81 -0.31 1.47e-8 Response to cytadine analogues (cytosine arabinoside); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg10899768 chr8:102506635 GRHL2 0.32 6.14 0.32 2.44e-9 Liver disease severity in Alagille syndrome; CRC cis rs354033 0.959 rs735120 chr7:149313811 C/T cg24335155 chr7:149193227 ZNF746 0.38 5.98 0.31 5.78e-9 Multiple sclerosis; CRC cis rs6484504 0.553 rs7113880 chr11:31279557 A/G cg14844989 chr11:31128820 NA -0.34 -6.11 -0.32 2.88e-9 Red blood cell count; CRC cis rs9611565 0.512 rs1983576 chr22:42166486 G/A cg06481639 chr22:41940642 POLR3H 0.56 6.19 0.32 1.75e-9 Vitiligo; CRC trans rs746629 0.528 rs4899811 chr14:83241901 A/G cg04246003 chr19:47987151 KPTN -0.45 -6.0 -0.31 5.29e-9 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CRC cis rs10752881 0.809 rs3768613 chr1:183106296 G/C ch.1.3577855R chr1:183094577 LAMC1 0.82 13.99 0.61 3.3e-35 Colorectal cancer; CRC cis rs4713118 0.629 rs203890 chr6:28022248 T/C cg12172441 chr6:28176163 NA 0.57 7.25 0.37 2.99e-12 Parkinson's disease; CRC cis rs2976388 0.590 rs10110970 chr8:143820410 G/C cg10596483 chr8:143751796 JRK -0.45 -6.37 -0.33 6.4e-10 Urinary tract infection frequency; CRC cis rs4481887 0.927 rs4586010 chr1:248437568 G/A cg13385794 chr1:248469461 NA 0.41 7.34 0.38 1.66e-12 Common traits (Other); CRC cis rs9487051 0.768 rs12176068 chr6:109521629 C/T cg21918786 chr6:109611834 NA -0.33 -5.63 -0.3 3.82e-8 Reticulocyte fraction of red cells; CRC cis rs1552244 0.832 rs61056817 chr3:10027641 C/T cg18598329 chr3:10140678 FANCD2;C3orf24 -0.75 -8.89 -0.44 4e-17 Alzheimer's disease; CRC cis rs35306767 0.715 rs12772979 chr10:1034412 C/T cg20503657 chr10:835505 NA 0.94 10.72 0.51 3.35e-23 Eosinophil percentage of granulocytes; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg03509813 chr4:17812473 NCAPG;DCAF16 0.37 6.1 0.32 3.05e-9 Liver disease severity in Alagille syndrome; CRC trans rs11250098 0.541 rs6997839 chr8:10766028 T/C cg06636001 chr8:8085503 FLJ10661 -0.52 -7.7 -0.39 1.62e-13 Morning vs. evening chronotype; CRC cis rs11212617 0.902 rs641312 chr11:108148265 T/C cg01991180 chr11:108092276 ATM;NPAT 0.41 5.86 0.31 1.1e-8 Response to metformin in type 2 diabetes (glycemic); CRC cis rs2011503 1.000 rs4808206 chr19:19645645 C/A cg11584989 chr19:19387371 SF4 0.59 6.55 0.34 2.25e-10 Bipolar disorder; CRC cis rs11758351 0.588 rs2050948 chr6:26234952 A/G cg22723502 chr6:26240528 HIST1H4F -0.36 -5.92 -0.31 8.02e-9 Gout;Renal underexcretion gout; CRC cis rs8072100 0.817 rs12449647 chr17:45548958 C/A cg25173405 chr17:45401733 C17orf57 -0.43 -6.68 -0.35 1e-10 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs56114371 0.530 rs9348774 chr6:27688930 C/T cg06470822 chr6:28175283 NA 0.53 6.33 0.33 8.16e-10 Breast cancer; CRC trans rs2303319 0.504 rs62187652 chr2:162468033 C/G cg12500891 chr11:57225987 NA -0.67 -6.03 -0.32 4.43e-9 Cognitive function; CRC cis rs4555082 0.874 rs2735828 chr14:105710486 C/A cg18132624 chr14:105716052 BTBD6;BRF1 -0.45 -7.42 -0.38 1.02e-12 Mean platelet volume;Platelet distribution width; CRC cis rs7937682 0.889 rs7926485 chr11:111536670 G/A cg09085632 chr11:111637200 PPP2R1B -1.0 -20.52 -0.75 7.88e-61 Primary sclerosing cholangitis; CRC trans rs7267979 1.000 rs6050590 chr20:25384994 G/A cg17903999 chr18:56338584 MALT1 0.42 6.93 0.36 2.17e-11 Liver enzyme levels (alkaline phosphatase); CRC cis rs13315871 1.000 rs36097398 chr3:58367330 G/A cg20936604 chr3:58311152 NA -0.75 -6.88 -0.35 3.02e-11 Cholesterol, total; CRC cis rs13108904 0.870 rs4974545 chr4:1271923 C/T cg20092199 chr4:1342459 KIAA1530 0.33 5.61 0.3 4.32e-8 Obesity-related traits; CRC cis rs9291683 0.597 rs11722989 chr4:10126139 A/G cg00071950 chr4:10020882 SLC2A9 -0.49 -8.31 -0.42 2.53e-15 Bone mineral density; CRC cis rs2580764 0.565 rs35631428 chr2:55244438 G/A cg09592903 chr2:55203963 RTN4 -0.64 -10.17 -0.49 2.67e-21 Mean platelet volume; CRC cis rs4713118 0.869 rs6922574 chr6:27693003 A/T cg20933634 chr6:27740509 NA 0.59 8.51 0.42 6.14e-16 Parkinson's disease; CRC cis rs651907 0.557 rs1056579 chr3:101397877 T/G cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.62 8.41 0.42 1.3e-15 Colorectal cancer; CRC cis rs8044995 0.563 rs3785127 chr16:68399590 C/G cg09835421 chr16:68378352 PRMT7 -0.8 -8.3 -0.42 2.67e-15 Schizophrenia; CRC cis rs6921919 0.583 rs7775132 chr6:28347013 T/C cg21251018 chr6:28226885 NKAPL 0.39 6.02 0.31 4.74e-9 Autism spectrum disorder or schizophrenia; CRC cis rs6933660 0.646 rs3816778 chr6:151773353 G/C cg02564969 chr6:151773285 C6orf211;RMND1 0.43 6.03 0.32 4.46e-9 Menarche (age at onset); CRC trans rs4689592 0.513 rs3857178 chr4:7066516 G/A cg07817883 chr1:32538562 TMEM39B -0.63 -7.9 -0.4 4.1e-14 Monocyte percentage of white cells; CRC cis rs875971 0.545 rs13311962 chr7:66068129 C/T cg11764359 chr7:65958608 NA -0.46 -5.79 -0.3 1.65e-8 Aortic root size; CRC cis rs10865541 0.870 rs6548161 chr2:3424350 A/G cg22182287 chr2:3452347 TTC15 0.42 6.7 0.35 9.14e-11 Obesity-related traits; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg01510332 chr19:59087201 MGC2752 0.49 6.32 0.33 8.61e-10 Thyroid stimulating hormone; CRC cis rs6502050 0.634 rs11077973 chr17:80095191 C/T cg13198984 chr17:80129470 CCDC57 0.46 8.16 0.41 6.94e-15 Life satisfaction; CRC cis rs763121 0.853 rs2267395 chr22:39113903 C/T cg06022373 chr22:39101656 GTPBP1 0.82 13.28 0.59 1.59e-32 Menopause (age at onset); CRC cis rs9322193 0.847 rs62439808 chr6:149950826 C/T cg00933542 chr6:150070202 PCMT1 0.29 6.09 0.32 3.07e-9 Lung cancer; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg13950210 chr1:45452319 EIF2B3 0.44 6.17 0.32 2e-9 Anxiety disorder; CRC cis rs514406 0.607 rs6696940 chr1:53203427 C/T cg25767906 chr1:53392781 SCP2 0.42 6.65 0.34 1.24e-10 Monocyte count; CRC cis rs755249 0.567 rs41270807 chr1:39801815 A/C cg18385671 chr1:39797026 MACF1 -0.41 -5.77 -0.3 1.81e-8 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs853679 0.517 rs9393894 chr6:28112562 A/G cg18032046 chr6:28092343 ZSCAN16 -0.51 -5.93 -0.31 7.47e-9 Depression; CRC cis rs72634258 0.554 rs35123409 chr1:7878568 C/T cg26816564 chr1:7831052 VAMP3 0.93 9.98 0.48 1.11e-20 Inflammatory bowel disease; CRC cis rs6735179 0.607 rs10185594 chr2:1746661 G/A cg19300414 chr2:1746591 PXDN 0.44 7.37 0.38 1.39e-12 Response to antipsychotic treatment; CRC cis rs2836974 0.897 rs2836927 chr21:40543216 T/C cg17971929 chr21:40555470 PSMG1 0.81 11.76 0.54 6.78e-27 Cognitive function; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg02659854 chr13:24824078 SPATA13 0.3 6.77 0.35 6.1e-11 Liver disease severity in Alagille syndrome; CRC cis rs115344852 0.575 rs1015811 chr6:28448086 A/G cg06470822 chr6:28175283 NA 0.49 5.81 0.31 1.45e-8 Epithelial ovarian cancer; CRC cis rs1707322 1.000 rs12077974 chr1:46384141 G/A cg06784218 chr1:46089804 CCDC17 0.49 8.19 0.41 5.85e-15 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs13108904 0.967 rs4405964 chr4:1278814 A/G cg02018176 chr4:1364513 KIAA1530 0.48 7.93 0.4 3.43e-14 Obesity-related traits; CRC cis rs6912958 0.781 rs6916732 chr6:88259225 C/T cg12350822 chr6:88032061 C6orf162;GJB7 -0.33 -6.36 -0.33 6.84e-10 Monocyte percentage of white cells; CRC cis rs6701037 0.681 rs1894709 chr1:175132371 G/T cg14847009 chr1:175162515 KIAA0040 -0.27 -5.99 -0.31 5.38e-9 Alcohol dependence; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg00209424 chr2:55277876 RTN4 0.39 6.27 0.33 1.13e-9 Liver disease severity in Alagille syndrome; CRC cis rs909002 1.000 rs2292993 chr1:32140733 C/T cg01639898 chr1:32083012 HCRTR1 0.28 5.64 0.3 3.57e-8 Intelligence (multi-trait analysis); CRC cis rs2839186 0.619 rs55689527 chr21:47622727 A/G cg12516959 chr21:47718080 NA -0.32 -5.7 -0.3 2.67e-8 Testicular germ cell tumor; CRC cis rs4665809 0.556 rs6730311 chr2:26419474 C/T cg27170947 chr2:26402098 FAM59B -0.63 -8.27 -0.41 3.3e-15 Gut microbiome composition (summer); CRC cis rs2806561 0.765 rs643492 chr1:23501354 C/T cg12483005 chr1:23474871 LUZP1 -0.49 -7.01 -0.36 1.38e-11 Height; CRC cis rs2011503 0.882 rs4808958 chr19:19571752 G/A cg11584989 chr19:19387371 SF4 0.52 5.75 0.3 2.02e-8 Bipolar disorder; CRC cis rs4555082 0.957 rs3000073 chr14:105729792 G/A cg18132624 chr14:105716052 BTBD6;BRF1 -0.43 -7.11 -0.36 7.35e-12 Mean platelet volume;Platelet distribution width; CRC cis rs10504229 0.683 rs11775506 chr8:58133639 G/T cg05313129 chr8:58192883 C8orf71 -0.45 -6.27 -0.33 1.12e-9 Developmental language disorder (linguistic errors); CRC trans rs116095464 0.558 rs2162870 chr5:228129 G/A cg00938859 chr5:1591904 SDHAP3 0.72 7.96 0.4 2.76e-14 Breast cancer; CRC cis rs7953249 0.594 rs11065384 chr12:121423285 T/C cg02403541 chr12:121454288 C12orf43 -0.39 -5.73 -0.3 2.3e-8 Invasive epithelial ovarian cancer;High-grade serous ovarian cancer;Chronic obstructive pulmonary disease-related biomarkers;N-glycan levels;Serous invasive ovarian cancer;Epithelial ovarian cancer; CRC cis rs7677751 0.806 rs7679903 chr4:55097373 T/C cg17187183 chr4:55093834 PDGFRA 0.52 7.37 0.38 1.36e-12 Corneal astigmatism; CRC cis rs13118159 0.550 rs4974617 chr4:1373658 T/C cg20887711 chr4:1340912 KIAA1530 0.71 10.09 0.49 4.95e-21 Longevity; CRC cis rs11212617 0.934 rs11212551 chr11:108078693 G/T cg14761454 chr11:108092087 ATM;NPAT 0.43 6.48 0.34 3.33e-10 Response to metformin in type 2 diabetes (glycemic); CRC cis rs9937943 0.615 rs12925346 chr16:74492495 G/C cg01733217 chr16:74700730 RFWD3 0.71 7.9 0.4 4.16e-14 Neutrophil percentage of white cells; CRC cis rs11625487 0.609 rs17824567 chr14:77976450 G/T cg06469542 chr14:77965869 ISM2 0.48 5.92 0.31 8.1e-9 Neutrophil percentage of white cells;Sum neutrophil eosinophil counts;Neutrophil count; CRC cis rs17253792 0.822 rs112418863 chr14:56114079 G/A cg24579896 chr14:56047964 C14orf33;KTN1 0.7 5.6 0.3 4.53e-8 Putamen volume; CRC cis rs28493229 0.708 rs10408309 chr19:41161189 T/G cg21869046 chr19:41225005 ITPKC 0.41 6.15 0.32 2.26e-9 Kawasaki disease; CRC cis rs6570726 0.935 rs447818 chr6:145868996 C/T cg23711669 chr6:146136114 FBXO30 0.71 12.46 0.57 1.8e-29 Lobe attachment (rater-scored or self-reported); CRC cis rs9560113 1.000 rs914026 chr13:112182029 G/A cg10483660 chr13:112241077 NA 0.37 5.94 0.31 7.28e-9 Menarche (age at onset); CRC cis rs76419734 0.510 rs2553463 chr4:106730663 C/T cg24545054 chr4:106630052 GSTCD;INTS12 -0.54 -6.16 -0.32 2.14e-9 Post bronchodilator FEV1; CRC cis rs6952808 0.825 rs34922657 chr7:1938655 C/T cg00106254 chr7:1943704 MAD1L1 -0.51 -7.63 -0.39 2.58e-13 Bipolar disorder and schizophrenia; CRC cis rs769267 0.896 rs10410664 chr19:19556651 G/A cg01262667 chr19:19385393 TM6SF2 0.37 6.05 0.32 3.94e-9 Tonsillectomy; CRC cis rs71403859 0.803 rs8063455 chr16:71599977 G/A cg08717414 chr16:71523259 ZNF19 -1.05 -9.88 -0.48 2.54e-20 Post bronchodilator FEV1; CRC cis rs2046867 0.818 rs17010188 chr3:72870351 T/C cg25664220 chr3:72788482 NA -0.47 -6.85 -0.35 3.66e-11 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; CRC cis rs10504229 0.953 rs114853497 chr8:58176176 A/T cg02290350 chr8:58132656 NA -0.42 -5.96 -0.31 6.62e-9 Developmental language disorder (linguistic errors); CRC cis rs10450586 0.863 rs7126943 chr11:27303937 A/G cg10370305 chr11:27303972 NA -0.39 -6.38 -0.33 6.18e-10 Total body bone mineral density; CRC trans rs3780486 0.846 rs10813954 chr9:33137596 A/C cg20290983 chr6:43655470 MRPS18A 1.17 24.85 0.81 1.79e-77 IgG glycosylation; CRC cis rs1997103 0.954 rs9649780 chr7:55411741 A/C cg17469321 chr7:55412551 NA 0.72 11.16 0.52 9.35e-25 QRS interval (sulfonylurea treatment interaction); CRC cis rs4820294 0.926 rs62236671 chr22:38069305 G/A cg21798802 chr22:38057573 PDXP 0.47 7.56 0.38 4.01e-13 Fat distribution (HIV); CRC cis rs7827545 1.000 rs1372659 chr8:135566779 T/A cg07299736 chr8:135490787 ZFAT -0.38 -6.42 -0.33 4.65e-10 Hypertension (SNP x SNP interaction); CRC trans rs2303319 0.504 rs62189047 chr2:162613314 T/A cg22902534 chr3:183892754 AP2M1 -0.7 -6.1 -0.32 2.96e-9 Cognitive function; CRC cis rs9341808 0.754 rs6918172 chr6:81019242 A/G cg08355045 chr6:80787529 NA 0.35 5.63 0.3 3.93e-8 Sitting height ratio; CRC cis rs1059312 0.771 rs7974764 chr12:129296588 G/C cg21616243 chr12:129299702 MGC16384;SLC15A4 -0.75 -13.27 -0.59 1.76e-32 Systemic lupus erythematosus; CRC cis rs7726839 0.561 rs56410216 chr5:583216 C/A cg09021430 chr5:549028 NA -0.86 -10.93 -0.52 6.42e-24 Obesity-related traits; CRC cis rs11785693 0.862 rs11780705 chr8:4988221 G/A cg26367366 chr8:4980734 NA 0.91 11.15 0.52 1.08e-24 Neuroticism (multi-trait analysis);Neuroticism; CRC cis rs10979 1.000 rs9390110 chr6:143893413 A/G cg25407410 chr6:143891975 LOC285740 -0.84 -13.81 -0.61 1.61e-34 Hypospadias; CRC cis rs473651 0.935 rs578510 chr2:239343140 C/T cg08773314 chr2:239334832 ASB1 0.38 8.73 0.43 1.29e-16 Multiple system atrophy; CRC cis rs7937682 0.961 rs7119563 chr11:111543916 T/A cg09085632 chr11:111637200 PPP2R1B 1.01 18.64 0.72 1.9e-53 Primary sclerosing cholangitis; CRC cis rs7246657 0.943 rs2045908 chr19:37979768 C/G cg23950597 chr19:37808831 NA -0.48 -5.79 -0.3 1.6e-8 Coronary artery calcification; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg13265437 chr11:32851260 PRRG4 0.45 6.42 0.33 4.88e-10 Response to antipsychotic treatment; CRC trans rs11098499 0.697 rs11941899 chr4:120382758 C/A cg25214090 chr10:38739885 LOC399744 0.66 10.55 0.5 1.36e-22 Corneal astigmatism; CRC cis rs2797685 1.000 rs2797685 chr1:7879063 C/T cg04725166 chr1:7887271 PER3 -0.45 -5.81 -0.3 1.51e-8 Crohn's disease; CRC cis rs11971779 0.680 rs3924296 chr7:139041927 T/C cg07862535 chr7:139043722 LUC7L2 0.57 7.35 0.38 1.61e-12 Diisocyanate-induced asthma; CRC cis rs3751196 0.615 rs17034620 chr12:104211278 C/A cg02344784 chr12:104178138 NT5DC3 0.71 7.54 0.38 4.58e-13 Sense of smell; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg00622580 chr2:62082097 FAM161A 0.42 6.25 0.33 1.28e-9 Intelligence (multi-trait analysis); CRC cis rs7586879 0.828 rs12986610 chr2:25106265 A/G cg04586622 chr2:25135609 ADCY3 0.59 10.06 0.49 6.15e-21 Body mass index; CRC trans rs8002861 0.846 rs12867732 chr13:44483084 C/A cg12856521 chr11:46389249 DGKZ -0.44 -6.98 -0.36 1.61e-11 Leprosy; CRC cis rs9894429 0.789 rs8074989 chr17:79598728 G/C cg18240062 chr17:79603768 NPLOC4 0.66 11.83 0.55 3.94e-27 Eye color traits; CRC cis rs231513 0.954 rs231510 chr17:41966470 T/C cg26893861 chr17:41843967 DUSP3 -0.63 -6.41 -0.33 5.01e-10 Cognitive function; CRC cis rs7647973 0.560 rs62262671 chr3:49649873 A/G cg03060546 chr3:49711283 APEH -0.58 -5.72 -0.3 2.35e-8 Menarche (age at onset); CRC cis rs9443645 0.901 rs4565265 chr6:79741958 A/G cg05283184 chr6:79620031 NA -0.62 -9.73 -0.47 7.88e-20 Intelligence (multi-trait analysis); CRC cis rs11792861 0.926 rs11788904 chr9:111865052 T/C cg05043794 chr9:111880884 C9orf5 -0.36 -6.55 -0.34 2.2e-10 Menarche (age at onset); CRC cis rs9393692 0.620 rs9379842 chr6:26289310 C/T cg13736514 chr6:26305472 NA 0.44 7.39 0.38 1.26e-12 Educational attainment; CRC cis rs11252926 0.527 rs10904093 chr10:436848 A/G cg18196295 chr10:418757 DIP2C -0.59 -8.98 -0.44 2.16e-17 Psychosis in Alzheimer's disease; CRC cis rs7120118 0.517 rs12575157 chr11:47272746 A/G cg25783544 chr11:47291846 MADD 0.61 5.61 0.3 4.24e-8 HDL cholesterol; CRC cis rs514406 0.893 rs479569 chr1:53352407 C/T cg08859206 chr1:53392774 SCP2 -0.49 -7.72 -0.39 1.41e-13 Monocyte count; CRC cis rs853679 0.517 rs34716816 chr6:28046169 C/A cg02683197 chr6:28174875 NA 0.79 9.73 0.47 8.12e-20 Depression; CRC cis rs10883723 0.810 rs2296588 chr10:104248087 T/C cg11453585 chr10:104263688 ACTR1A;SUFU 0.92 17.46 0.69 8.98e-49 Allergic disease (asthma, hay fever or eczema); CRC cis rs3099143 0.901 rs78020233 chr15:77107050 T/G cg21673338 chr15:77095150 SCAPER -0.78 -6.45 -0.33 4.05e-10 Recalcitrant atopic dermatitis; CRC trans rs61931739 0.500 rs7309421 chr12:34553795 C/T cg26384229 chr12:38710491 ALG10B 0.67 8.79 0.44 8.45e-17 Morning vs. evening chronotype; CRC cis rs77633900 0.772 rs283799 chr15:76752834 A/C cg21673338 chr15:77095150 SCAPER -0.68 -6.22 -0.32 1.54e-9 Non-glioblastoma glioma;Glioma; CRC cis rs9905704 0.831 rs12949598 chr17:56707245 C/T cg12560992 chr17:57184187 TRIM37 0.56 7.63 0.39 2.5e-13 Testicular germ cell tumor; CRC cis rs1799949 1.000 rs33920795 chr17:41329010 A/G cg23758822 chr17:41437982 NA 0.8 13.62 0.6 8.51e-34 Menopause (age at onset); CRC cis rs911119 0.657 rs2145231 chr20:23625547 A/G cg16589663 chr20:23618590 CST3 -0.59 -7.46 -0.38 8.03e-13 Chronic kidney disease; CRC trans rs916888 0.821 rs199512 chr17:44857352 T/C cg01341218 chr17:43662625 NA -0.83 -9.39 -0.46 1.03e-18 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs7726839 0.540 rs28364691 chr5:664084 G/A cg16447950 chr5:562315 NA -0.81 -10.49 -0.5 2.1e-22 Obesity-related traits; CRC cis rs12476592 0.571 rs7584404 chr2:63794342 C/T cg10828910 chr2:63850056 LOC388955 0.49 6.11 0.32 2.79e-9 Childhood ear infection; CRC cis rs7666738 0.830 rs13138063 chr4:99050438 A/C cg05340658 chr4:99064831 C4orf37 0.6 9.24 0.45 3.19e-18 Colonoscopy-negative controls vs population controls; CRC cis rs736408 0.546 rs3733046 chr3:52621627 C/T cg18404041 chr3:52824283 ITIH1 -0.4 -8.3 -0.42 2.66e-15 Bipolar disorder; CRC cis rs4660306 1.000 rs882803 chr1:45976147 G/A cg03123370 chr1:45965343 CCDC163P;MMACHC -0.55 -8.16 -0.41 7.28e-15 Homocysteine levels; CRC cis rs2836974 0.627 rs9981301 chr21:40686078 G/C cg11890956 chr21:40555474 PSMG1 -0.83 -13.07 -0.58 9.83e-32 Cognitive function; CRC cis rs4474465 1.000 rs10899522 chr11:78190763 C/G cg27205649 chr11:78285834 NARS2 0.49 5.94 0.31 7.3e-9 Alzheimer's disease (survival time); CRC cis rs67311347 1.000 rs73078123 chr3:40458963 G/A cg24209194 chr3:40518798 ZNF619 0.4 5.65 0.3 3.54e-8 Renal cell carcinoma; CRC cis rs13082711 0.911 rs17682229 chr3:27443067 T/C cg02860705 chr3:27208620 NA 0.61 8.64 0.43 2.43e-16 Systolic blood pressure;Diastolic blood pressure;Blood pressure; CRC trans rs2228479 0.717 rs62052210 chr16:89980158 A/G cg24644049 chr4:85504048 CDS1 0.7 7.01 0.36 1.4e-11 Skin colour saturation; CRC cis rs2075165 0.901 rs2296374 chr1:156287403 T/C cg20302342 chr1:156215951 PAQR6 0.38 7.27 0.37 2.67e-12 Tonsillectomy; CRC cis rs11190604 1.000 rs4244338 chr10:102272802 A/G cg16342193 chr10:102329863 NA -0.35 -5.83 -0.31 1.3e-8 Palmitoleic acid (16:1n-7) levels; CRC cis rs2006209 0.536 rs10414640 chr19:42097086 A/G cg10389454 chr19:42083748 CEACAM21 -0.47 -5.72 -0.3 2.34e-8 Lung adenocarcinoma; CRC cis rs6696846 0.765 rs11577406 chr1:205065733 G/T cg00857998 chr1:205179979 DSTYK 0.46 6.33 0.33 8.07e-10 Red blood cell count; CRC cis rs853679 0.766 rs9368561 chr6:28168343 C/T cg15845792 chr6:28175446 NA 0.78 6.33 0.33 7.82e-10 Depression; CRC cis rs7786808 0.741 rs11767875 chr7:158228923 A/G cg17401720 chr7:158221031 PTPRN2 0.46 7.64 0.39 2.35e-13 Obesity-related traits; CRC cis rs709400 0.526 rs11622835 chr14:103967504 G/A cg12935359 chr14:103987150 CKB -0.69 -9.25 -0.45 2.84e-18 Body mass index; CRC cis rs780096 0.526 rs1647267 chr2:27651054 A/T cg27432699 chr2:27873401 GPN1 -0.5 -7.66 -0.39 2.06e-13 Total body bone mineral density; CRC cis rs644799 1.000 rs474442 chr11:95583995 A/G cg25478527 chr11:95522999 CEP57;FAM76B 0.5 7.55 0.38 4.42e-13 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs2949837 0.581 rs2960436 chr7:45977282 G/A cg06713098 chr7:45960367 IGFBP3 0.42 6.71 0.35 8.43e-11 Sitting height ratio; CRC cis rs9322193 0.884 rs1108889 chr6:150166569 A/G cg07701084 chr6:150067640 NUP43 0.54 7.4 0.38 1.16e-12 Lung cancer; CRC trans rs4378999 0.668 rs9864443 chr3:51656376 C/G cg22768531 chr19:49403500 NUCB1 -0.51 -6.16 -0.32 2.17e-9 Waist circumference adjusted for BMI in non-smokers;Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction); CRC cis rs7523050 0.643 rs34096625 chr1:109401101 G/A cg08274380 chr1:109419600 GPSM2 0.84 6.6 0.34 1.69e-10 Fat distribution (HIV); CRC cis rs875971 0.895 rs6460278 chr7:65662736 T/C cg18876405 chr7:65276391 NA -0.54 -8.74 -0.43 1.21e-16 Aortic root size; CRC cis rs769267 0.965 rs2315281 chr19:19480099 G/A cg01262667 chr19:19385393 TM6SF2 -0.38 -6.33 -0.33 7.89e-10 Tonsillectomy; CRC cis rs12999616 1.000 rs12999616 chr2:98324381 C/T cg26665480 chr2:98280029 ACTR1B 0.65 7.42 0.38 1.01e-12 Colorectal cancer; CRC trans rs2243480 0.901 rs13237344 chr7:66022256 T/A cg10756647 chr7:56101905 PSPH 0.77 8.03 0.4 1.78e-14 Diabetic kidney disease; CRC cis rs5769765 0.773 rs9616391 chr22:50314573 C/T cg22709217 chr22:50311962 ALG12;CRELD2 -1.04 -14.98 -0.64 4.86e-39 Schizophrenia; CRC cis rs644799 0.601 rs568878 chr11:95578694 G/T cg25622487 chr11:95524042 FAM76B;CEP57 0.71 11.43 0.53 1.02e-25 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs10504229 0.728 rs1495867 chr8:58155500 G/T cg02725872 chr8:58115012 NA -0.57 -9.07 -0.45 1.09e-17 Developmental language disorder (linguistic errors); CRC cis rs7617773 0.778 rs11707997 chr3:48377875 A/G cg11946769 chr3:48343235 NME6 0.74 9.91 0.48 2.03e-20 Coronary artery disease; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg24014487 chr20:36793744 TGM2 0.42 5.98 0.31 5.79e-9 Anxiety disorder; CRC cis rs7524258 0.901 rs11120884 chr1:7305361 C/A cg07173049 chr1:7289937 CAMTA1 0.51 8.25 0.41 3.81e-15 Tourette's syndrome or obsessive-compulsive disorder; CRC cis rs6089584 0.566 rs2181589 chr20:60622817 C/T cg23463467 chr20:60627584 TAF4 -0.42 -8.45 -0.42 9.49e-16 Body mass index; CRC cis rs7949030 1.000 rs7949030 chr11:62394881 A/G cg13298116 chr11:62369859 EML3;MTA2 0.55 9.58 0.47 2.51e-19 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; CRC cis rs1552244 0.572 rs7645667 chr3:10157337 C/A cg00166722 chr3:10149974 C3orf24 0.7 8.12 0.41 9.45e-15 Alzheimer's disease; CRC cis rs736408 0.527 rs2577831 chr3:52628056 C/A cg08222913 chr3:52553049 STAB1 -0.39 -7.65 -0.39 2.29e-13 Bipolar disorder; CRC cis rs362272 0.524 rs10937924 chr4:3374898 T/C cg02993699 chr4:3415135 RGS12 -0.38 -6.27 -0.33 1.14e-9 Serum sulfate level; CRC cis rs3806843 0.778 rs2531346 chr5:140126139 T/G cg16607685 chr5:140181889 PCDHA2;PCDHA1;PCDHA3 0.26 6.15 0.32 2.23e-9 Depressive symptoms (multi-trait analysis); CRC cis rs7572644 0.603 rs4666013 chr2:28019106 C/T cg27432699 chr2:27873401 GPN1 0.46 5.67 0.3 3.07e-8 Response to carboplatin and paclitaxel in ovarian cancer (Caspase 3/7 EC50); CRC cis rs9443645 0.670 rs79209669 chr6:79719623 C/G cg05283184 chr6:79620031 NA -0.61 -9.64 -0.47 1.54e-19 Intelligence (multi-trait analysis); CRC cis rs6582630 0.519 rs4294627 chr12:38293982 C/T cg13010199 chr12:38710504 ALG10B 0.47 6.29 0.33 1.01e-9 Drug-induced liver injury (flucloxacillin); CRC cis rs11148252 0.766 rs74697307 chr13:52897573 C/T cg00495681 chr13:53174319 NA -0.6 -9.08 -0.45 9.96e-18 Lewy body disease; CRC cis rs4722166 0.573 rs35436671 chr7:22775508 G/A cg26061582 chr7:22766209 IL6 0.55 8.33 0.42 2.19e-15 Lung cancer; CRC cis rs71403859 0.667 rs12149264 chr16:71720921 T/G cg08717414 chr16:71523259 ZNF19 -0.98 -9.09 -0.45 9.46e-18 Post bronchodilator FEV1; CRC cis rs11112613 0.713 rs2374502 chr12:105938939 T/C cg03607813 chr12:105948248 NA 0.76 10.01 0.48 9.4e-21 Corrected insulin response;Corrected insulin response adjusted for insulin sensitivity index; CRC cis rs6598955 0.543 rs12122527 chr1:26549748 C/T cg04990556 chr1:26633338 UBXN11 0.89 11.13 0.52 1.21e-24 Obesity-related traits; CRC cis rs9969804 0.682 rs10761168 chr9:95505560 A/G cg14631576 chr9:95140430 CENPP -0.32 -5.94 -0.31 7.16e-9 Height; CRC cis rs9902453 0.791 rs2628166 chr17:28113123 T/C cg26525008 chr17:28256777 EFCAB5;SSH2 -0.58 -8.75 -0.43 1.1e-16 Coffee consumption (cups per day); CRC cis rs8053891 0.615 rs2287997 chr16:72140553 G/A cg01557791 chr16:72042693 DHODH -0.53 -5.69 -0.3 2.78e-8 Coronary artery disease; CRC cis rs877282 0.945 rs11253396 chr10:789754 C/T cg17470449 chr10:769945 NA 0.68 9.03 0.45 1.48e-17 Uric acid levels; CRC cis rs58688157 0.639 rs60568231 chr11:575553 A/T cg03909863 chr11:638404 DRD4 -0.47 -6.1 -0.32 3.04e-9 Systemic lupus erythematosus; CRC cis rs9837602 0.938 rs28503408 chr3:99794842 G/A cg07805332 chr3:99536008 MIR548G;C3orf26 -0.5 -6.65 -0.34 1.2e-10 Breast cancer; CRC cis rs875971 0.929 rs34406470 chr7:65929956 A/G cg18876405 chr7:65276391 NA 0.52 8.92 0.44 3.2e-17 Aortic root size; CRC cis rs9649213 0.593 rs7807555 chr7:97957517 G/A cg21770322 chr7:97807741 LMTK2 0.52 8.54 0.43 5.11e-16 Prostate cancer (SNP x SNP interaction); CRC cis rs9462027 0.651 rs7769820 chr6:34760228 C/T cg07306190 chr6:34760872 UHRF1BP1 -0.35 -6.24 -0.33 1.31e-9 Systemic lupus erythematosus; CRC trans rs6561151 0.957 rs1373904 chr13:44475398 A/G cg12856521 chr11:46389249 DGKZ 0.62 9.28 0.46 2.32e-18 Crohn's disease; CRC trans rs2172802 0.693 rs7660566 chr4:62481231 G/T cg01233948 chr15:31318495 TRPM1 0.44 6.02 0.31 4.68e-9 Partial epilepsies; CRC cis rs2153535 0.580 rs9328488 chr6:8529411 G/C cg07606381 chr6:8435919 SLC35B3 0.68 11.04 0.52 2.48e-24 Motion sickness; CRC cis rs10927875 0.541 rs1763607 chr1:16337509 G/A cg24140574 chr1:16342155 HSPB7 0.44 6.14 0.32 2.34e-9 Dilated cardiomyopathy; CRC cis rs4285028 0.699 rs2689290 chr3:121585146 C/T cg11130432 chr3:121712080 ILDR1 -0.47 -6.12 -0.32 2.69e-9 Multiple sclerosis; CRC cis rs1552244 1.000 rs67569278 chr3:10149893 T/C cg13047869 chr3:10149882 C3orf24 0.55 7.31 0.37 2.11e-12 Alzheimer's disease; CRC cis rs11098499 0.780 rs10013652 chr4:120292256 A/G cg24375607 chr4:120327624 NA 0.48 7.51 0.38 5.47e-13 Corneal astigmatism; CRC cis rs1552244 0.572 rs7645759 chr3:10157368 C/T cg10729496 chr3:10149963 C3orf24 0.51 5.86 0.31 1.13e-8 Alzheimer's disease; CRC cis rs28386778 0.897 rs896064 chr17:61860932 C/T cg11494091 chr17:61959527 GH2 0.62 10.57 0.5 1.11e-22 Prudent dietary pattern; CRC cis rs514406 0.698 rs511599 chr1:53362818 T/C cg08859206 chr1:53392774 SCP2 -0.59 -9.15 -0.45 6.2e-18 Monocyte count; CRC cis rs10504229 0.953 rs75585481 chr8:58192202 T/C cg22535103 chr8:58192502 C8orf71 -0.82 -12.27 -0.56 9.63e-29 Developmental language disorder (linguistic errors); CRC cis rs796364 1.000 rs769949 chr2:200729558 A/G cg25936922 chr2:200820526 C2orf60;C2orf47 0.7 7.82 0.4 7.23e-14 Schizophrenia; CRC cis rs970548 0.954 rs11239549 chr10:46018831 A/G cg15590007 chr10:45870220 ALOX5 0.51 6.38 0.33 5.98e-10 Total cholesterol levels;Cholesterol, total;HDL cholesterol;HDL cholesterol levels; CRC cis rs6088580 0.634 rs6141465 chr20:32967314 T/C cg08999081 chr20:33150536 PIGU -0.61 -11.34 -0.53 2.17e-25 Glomerular filtration rate (creatinine); CRC cis rs12745968 0.653 rs2107519 chr1:93192870 T/G cg17283838 chr1:93427260 FAM69A -0.47 -6.38 -0.33 6.1e-10 Bipolar disorder and schizophrenia; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg16263701 chr12:48213605 HDAC7 0.46 6.48 0.34 3.28e-10 Response to antipsychotic treatment; CRC cis rs2153535 0.580 rs7748455 chr6:8453625 C/T cg07606381 chr6:8435919 SLC35B3 0.68 10.99 0.52 3.81e-24 Motion sickness; CRC cis rs1552244 1.000 rs7619340 chr3:10108178 C/T cg10729496 chr3:10149963 C3orf24 0.58 7.52 0.38 5.23e-13 Alzheimer's disease; CRC cis rs2404602 0.716 rs12917430 chr15:76674360 T/C cg22467129 chr15:76604101 ETFA -0.45 -7.55 -0.38 4.39e-13 Blood metabolite levels; CRC cis rs1799949 0.965 rs8176140 chr17:41251646 T/A cg25072359 chr17:41440525 NA 0.47 6.95 0.36 1.94e-11 Menopause (age at onset); CRC cis rs8067545 0.611 rs7219615 chr17:20132558 T/A cg13482628 chr17:19912719 NA -0.46 -7.36 -0.38 1.44e-12 Schizophrenia; CRC cis rs1129187 0.935 rs9986447 chr6:42942779 C/T cg21280719 chr6:42927975 GNMT 0.43 9.22 0.45 3.77e-18 Alzheimer's disease in APOE e4+ carriers; CRC cis rs7937682 0.587 rs611607 chr11:111349765 C/T cg09085632 chr11:111637200 PPP2R1B -0.6 -8.86 -0.44 5.08e-17 Primary sclerosing cholangitis; CRC cis rs1552244 0.554 rs17050704 chr3:10045734 T/C cg02579736 chr3:10068473 FANCD2;CIDECP 0.66 9.24 0.45 3.11e-18 Alzheimer's disease; CRC cis rs4509693 1.000 rs6584394 chr10:102497258 G/A cg23167259 chr10:102495509 NA -0.47 -6.35 -0.33 6.97e-10 Alzheimer's disease; CRC cis rs6088580 0.660 rs6059893 chr20:33105897 T/G cg24642439 chr20:33292090 TP53INP2 0.39 6.6 0.34 1.68e-10 Glomerular filtration rate (creatinine); CRC trans rs9771228 0.965 rs1014242 chr7:32272305 C/T cg02979224 chr7:93204462 CALCR 0.34 5.96 0.31 6.43e-9 Cognitive ability;Verbal-numerical reasoning; CRC cis rs7474896 0.583 rs1735621 chr10:38167723 G/T cg25427524 chr10:38739819 LOC399744 0.67 8.14 0.41 8.16e-15 Obesity (extreme); CRC cis rs1552172 0.853 rs1471630 chr1:145707297 A/G cg11743829 chr1:145714124 CD160 -0.41 -6.06 -0.32 3.68e-9 Breast cancer; CRC cis rs9467773 0.620 rs2451711 chr6:26663110 A/G cg09904177 chr6:26538194 HMGN4 0.73 11.61 0.54 2.43e-26 Intelligence (multi-trait analysis); CRC cis rs7394190 0.688 rs76033784 chr10:75535970 A/G cg07699608 chr10:75541558 CHCHD1 0.61 6.38 0.33 5.99e-10 Incident atrial fibrillation; CRC cis rs3736485 0.844 rs12101858 chr15:51783981 C/G cg08986416 chr15:51914746 DMXL2 -0.45 -6.3 -0.33 9.39e-10 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs12023718 0.588 rs12042226 chr1:178589105 C/T cg00404053 chr1:178313656 RASAL2 0.61 7.47 0.38 7.13e-13 Obesity-related traits; CRC cis rs7949030 0.626 rs11231144 chr11:62328038 A/G cg11742103 chr11:62369870 EML3;MTA2 0.63 11.98 0.55 1.12e-27 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; CRC cis rs11723261 0.546 rs57839456 chr4:148289 C/G cg12746427 chr4:53362 ZNF718;ZNF595 0.49 6.83 0.35 4.04e-11 Immune response to smallpox vaccine (IL-6); CRC cis rs11785400 0.762 rs7460801 chr8:143730972 C/A cg24634471 chr8:143751801 JRK 0.52 7.15 0.37 5.69e-12 Schizophrenia; CRC cis rs4742903 0.967 rs2274725 chr9:106864570 C/T cg21169611 chr9:106856078 SMC2 0.41 5.8 0.3 1.6e-8 High-grade serous ovarian cancer;Breast cancer; CRC cis rs2933343 0.649 rs728839 chr3:128589359 A/G cg11901034 chr3:128598214 ACAD9 -0.55 -8.07 -0.41 1.36e-14 IgG glycosylation; CRC cis rs7666738 0.962 rs11932892 chr4:99072967 C/T cg03676636 chr4:99064102 C4orf37 0.23 6.44 0.33 4.12e-10 Colonoscopy-negative controls vs population controls; CRC cis rs9303280 0.901 rs12936231 chr17:38029120 C/G cg20243544 chr17:37824526 PNMT 0.42 6.57 0.34 2.02e-10 Self-reported allergy; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg22064942 chr4:110355472 SEC24B 0.48 6.73 0.35 7.62e-11 Response to antipsychotic treatment; CRC cis rs172166 0.516 rs2791333 chr6:28111114 A/G cg06470822 chr6:28175283 NA 0.66 10.14 0.49 3.46e-21 Cardiac Troponin-T levels; CRC cis rs2032447 0.714 rs199734 chr6:25940393 G/C cg03264133 chr6:25882463 NA -0.62 -8.61 -0.43 3.11e-16 Intelligence (multi-trait analysis); CRC trans rs6066835 1.000 rs4455220 chr20:47335017 A/G cg21109867 chr19:55897418 RPL28 -0.69 -6.03 -0.32 4.38e-9 Multiple myeloma; CRC cis rs6089584 0.888 rs6061981 chr20:60618973 T/C cg06108461 chr20:60628389 TAF4 -0.92 -15.9 -0.66 1.24e-42 Body mass index; CRC cis rs8105895 0.935 rs28374572 chr19:22276478 A/C cg02657401 chr19:22469223 NA -0.35 -5.67 -0.3 3.06e-8 Body mass index (change over time); CRC cis rs7677751 0.806 rs1800810 chr4:55094031 C/G cg00691999 chr4:55094011 PDGFRA 0.43 6.28 0.33 1.06e-9 Corneal astigmatism; CRC cis rs7091068 0.518 rs1409337 chr10:95439822 T/C cg20715218 chr10:95462985 C10orf4 0.56 7.54 0.38 4.6e-13 Urinary tract infection frequency; CRC cis rs7781266 0.842 rs17656452 chr7:133193425 G/A cg03336402 chr7:133662267 EXOC4 0.49 5.81 0.31 1.46e-8 Educational attainment (college completion); CRC cis rs7412746 0.658 rs10305714 chr1:150800655 C/T cg10589385 chr1:150898437 SETDB1 -0.3 -6.25 -0.33 1.29e-9 Melanoma; CRC cis rs4713118 0.662 rs149948 chr6:27974817 C/G cg02683197 chr6:28174875 NA 0.66 9.03 0.45 1.49e-17 Parkinson's disease; CRC cis rs6500602 0.727 rs4786516 chr16:4578641 C/T cg08645402 chr16:4508243 NA 0.63 11.1 0.52 1.63e-24 Schizophrenia; CRC cis rs62064224 0.589 rs9904964 chr17:30662832 A/G cg25809561 chr17:30822961 MYO1D -0.51 -9.0 -0.44 1.88e-17 Schizophrenia; CRC cis rs870825 0.616 rs7680835 chr4:185652992 C/G cg04058563 chr4:185651563 MLF1IP -0.69 -8.69 -0.43 1.68e-16 Blood protein levels; CRC cis rs3931020 0.548 rs969435 chr1:75273866 A/G cg17719053 chr1:75198211 TYW3;CRYZ -0.45 -5.84 -0.31 1.27e-8 Resistin levels; CRC cis rs9583531 0.600 rs7986286 chr13:111357207 A/G cg24331049 chr13:111365604 ING1 0.57 7.88 0.4 4.78e-14 Coronary artery disease; CRC cis rs6570726 0.791 rs392612 chr6:145881586 C/G cg23711669 chr6:146136114 FBXO30 -0.77 -13.29 -0.59 1.49e-32 Lobe attachment (rater-scored or self-reported); CRC cis rs6952808 0.723 rs60432611 chr7:2029629 G/C cg00106254 chr7:1943704 MAD1L1 -0.56 -8.2 -0.41 5.62e-15 Bipolar disorder and schizophrenia; CRC cis rs4727027 0.901 rs6944781 chr7:148829566 A/G cg23583168 chr7:148888333 NA -0.89 -15.19 -0.64 7.1e-40 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC cis rs4713118 0.824 rs9468223 chr6:27740666 C/T cg08798685 chr6:27730294 NA -0.49 -6.88 -0.35 3.05e-11 Parkinson's disease; CRC cis rs6693567 0.545 rs1313568 chr1:150344180 C/G cg15654264 chr1:150340011 RPRD2 0.43 6.41 0.33 5.06e-10 Migraine; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg01664130 chr13:99740155 DOCK9 0.47 6.06 0.32 3.74e-9 Thyroid stimulating hormone; CRC cis rs1552244 0.872 rs6792951 chr3:10119603 C/A cg13047869 chr3:10149882 C3orf24 0.53 7.4 0.38 1.18e-12 Alzheimer's disease; CRC cis rs2404602 0.583 rs12438741 chr15:76542114 C/A cg03037974 chr15:76606532 NA 0.84 16.86 0.68 2.06e-46 Blood metabolite levels; CRC cis rs7605827 0.930 rs6705287 chr2:15529368 A/C cg19274914 chr2:15703543 NA 0.39 5.88 0.31 9.87e-9 Educational attainment (years of education); CRC cis rs12887734 0.524 rs17791722 chr14:104286210 C/T cg08213375 chr14:104286397 PPP1R13B 0.49 8.46 0.42 8.65e-16 Schizophrenia;Autism spectrum disorder or schizophrenia; CRC cis rs2549003 1.000 rs17848418 chr5:131821188 C/T cg02551604 chr5:131831745 NA -0.54 -8.34 -0.42 2e-15 Asthma (sex interaction); CRC cis rs12681287 0.604 rs41469550 chr8:87406544 G/T cg27223183 chr8:87520930 FAM82B 0.52 7.08 0.36 8.71e-12 Caudate activity during reward; CRC cis rs2228479 0.850 rs3785279 chr16:89824562 G/C cg06656553 chr16:89960601 TCF25 -0.7 -5.76 -0.3 1.93e-8 Skin colour saturation; CRC cis rs9486719 0.948 rs2499813 chr6:96875338 T/C cg06623918 chr6:96969491 KIAA0776 0.81 9.51 0.46 4.17e-19 Migraine;Coronary artery disease; CRC cis rs10463316 0.894 rs6579860 chr5:150752338 G/A cg03212797 chr5:150827313 SLC36A1 -0.53 -8.35 -0.42 1.95e-15 Metabolite levels (Pyroglutamine); CRC cis rs4925386 0.840 rs6142738 chr20:60919960 C/T cg24112000 chr20:60950667 NA 0.51 8.25 0.41 3.87e-15 Colorectal cancer;Colorectal cancer (SNP x SNP interaction); CRC cis rs10540 1.000 rs71487296 chr11:500282 G/A cg03934478 chr11:495069 RNH1 0.7 7.83 0.4 6.8e-14 Body mass index; CRC cis rs9462846 0.959 rs57514728 chr6:42860748 C/T cg21280719 chr6:42927975 GNMT -0.33 -5.86 -0.31 1.11e-8 Blood protein levels; CRC cis rs76419734 0.510 rs2193856 chr4:106742958 A/C cg24545054 chr4:106630052 GSTCD;INTS12 -0.52 -6.03 -0.32 4.4e-9 Post bronchodilator FEV1; CRC cis rs270601 0.909 rs2569265 chr5:131704519 T/C cg11843238 chr5:131593191 PDLIM4 -0.44 -7.47 -0.38 7.39e-13 Acylcarnitine levels; CRC cis rs1862618 0.853 rs252910 chr5:56192983 G/A cg24531977 chr5:56204891 C5orf35 -0.9 -11.55 -0.54 3.86e-26 Initial pursuit acceleration; CRC cis rs12995491 0.698 rs34352413 chr2:88498754 T/G cg04511125 chr2:88470314 THNSL2 -0.44 -6.39 -0.33 5.8e-10 Response to metformin (IC50); CRC cis rs6541297 1.000 rs6541296 chr1:230281953 A/G cg05784532 chr1:230284198 GALNT2 0.46 6.29 0.33 1.04e-9 Coronary artery disease; CRC cis rs2836974 1.000 rs28360661 chr21:40681972 G/C cg11890956 chr21:40555474 PSMG1 0.98 15.07 0.64 2.23e-39 Cognitive function; CRC cis rs4919694 0.901 rs74376228 chr10:104677662 G/C cg04362960 chr10:104952993 NT5C2 1.21 10.67 0.51 5.18e-23 Arsenic metabolism; CRC cis rs116095464 0.558 rs6881920 chr5:222411 T/C cg22496380 chr5:211416 CCDC127 -0.83 -9.55 -0.47 3.03e-19 Breast cancer; CRC cis rs4523957 0.890 rs216218 chr17:2145329 A/G cg16513277 chr17:2031491 SMG6 0.54 9.05 0.45 1.24e-17 Autism spectrum disorder or schizophrenia;Schizophrenia; CRC trans rs2303319 0.504 rs62189042 chr2:162602320 G/T cg22922770 chr7:98923339 ARPC1A -0.67 -5.98 -0.31 5.68e-9 Cognitive function; CRC cis rs1568889 0.938 rs7128045 chr11:28190180 C/G cg06544937 chr11:28130018 METT5D1;KIF18A 0.8 11.58 0.54 3.17e-26 Bipolar disorder; CRC trans rs11976180 0.517 rs6949375 chr7:143773851 T/G cg00397059 chr6:132031294 CTAGE9;ENPP3 -0.8 -8.7 -0.43 1.58e-16 Obesity-related traits; CRC cis rs35110281 0.748 rs1584918 chr21:45042419 C/T cg04455712 chr21:45112962 RRP1B 0.41 8.02 0.4 1.88e-14 Mean corpuscular volume; CRC cis rs9486715 1.000 rs9373985 chr6:97063522 C/G cg06623918 chr6:96969491 KIAA0776 -0.97 -16.92 -0.68 1.24e-46 Headache; CRC cis rs13096480 0.583 rs17598137 chr3:49891362 G/T cg09092311 chr3:49142581 QARS 0.39 5.68 0.3 2.93e-8 Intelligence (multi-trait analysis); CRC cis rs4290604 0.665 rs4316893 chr2:238089767 T/C cg23555395 chr2:238036564 NA -0.6 -6.07 -0.32 3.57e-9 Asthma; CRC cis rs9322817 1.000 rs6900902 chr6:105235757 A/G cg02098413 chr6:105308735 HACE1 -0.33 -5.97 -0.31 6.17e-9 Thyroid stimulating hormone; CRC cis rs6963495 0.818 rs55825845 chr7:105166713 A/G cg02135003 chr7:105160482 PUS7 -0.91 -12.41 -0.56 2.87e-29 Bipolar disorder (body mass index interaction); CRC cis rs1348850 0.914 rs4893961 chr2:178411075 A/G cg22681709 chr2:178499509 PDE11A -0.36 -6.64 -0.34 1.32e-10 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs4972806 0.739 rs10834 chr2:177042087 A/G cg25347419 chr2:177043501 NA 0.47 6.69 0.35 9.63e-11 IgG glycosylation; CRC trans rs1814175 0.746 rs10839429 chr11:49906845 G/A cg11707556 chr5:10655725 ANKRD33B -0.44 -8.31 -0.42 2.52e-15 Height; CRC trans rs1005277 0.602 rs1780141 chr10:38504299 T/C cg17830980 chr10:43048298 ZNF37B -0.57 -9.66 -0.47 1.38e-19 Extrinsic epigenetic age acceleration; CRC cis rs9747347 1 rs9747347 chr17:79606820 T/C cg18268547 chr17:79615552 TSPAN10 0.33 8.01 0.4 1.96e-14 Myopia; CRC cis rs12477438 0.798 rs2123686 chr2:99690135 G/A cg14399236 chr2:99771627 LIPT1;TSGA10 -0.6 -8.19 -0.41 6.03e-15 Chronic sinus infection; CRC trans rs10983614 1.000 rs7867776 chr9:120072627 A/G cg24003225 chr3:184870891 C3orf70 0.44 6.04 0.32 4.06e-9 Survival in pancreatic cancer; CRC cis rs4555082 0.750 rs2816650 chr14:105708343 C/T cg13114125 chr14:105738426 BRF1 -0.77 -11.12 -0.52 1.29e-24 Mean platelet volume;Platelet distribution width; CRC trans rs61931739 0.500 rs7965421 chr12:34523624 G/T cg26384229 chr12:38710491 ALG10B 0.67 8.81 0.44 7.35e-17 Morning vs. evening chronotype; CRC cis rs11587400 0.572 rs2268697 chr1:115227493 A/G cg12756093 chr1:115239321 AMPD1 0.52 7.37 0.38 1.36e-12 Autism; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg09434832 chr19:52642515 ZNF616 0.39 6.05 0.32 3.85e-9 Liver disease severity in Alagille syndrome; CRC cis rs7258465 1.000 rs4595905 chr19:18547305 T/A cg06953865 chr19:18549723 ISYNA1 -0.39 -5.76 -0.3 1.89e-8 Breast cancer; CRC cis rs1005277 0.579 rs1621040 chr10:38497232 T/C cg25427524 chr10:38739819 LOC399744 -0.79 -14.48 -0.62 4.1e-37 Extrinsic epigenetic age acceleration; CRC cis rs933688 1.000 rs6865495 chr5:90746424 G/A cg26981201 chr5:90679533 LOC100129716;ARRDC3 1.02 17.16 0.69 1.33e-47 Smoking behavior; CRC trans rs703108 0.731 rs7898954 chr10:22323646 A/G cg07080067 chr5:68514103 MRPS36 -0.53 -6.31 -0.33 8.84e-10 Monocyte percentage of white cells; CRC trans rs7580658 0.614 rs7585198 chr2:127962635 C/T cg03035921 chr2:122407209 CLASP1 -0.43 -5.98 -0.31 5.73e-9 Protein C levels; CRC cis rs4664308 0.935 rs58354887 chr2:160927112 C/T cg03641300 chr2:160917029 PLA2R1 -0.73 -11.52 -0.54 4.95e-26 Idiopathic membranous nephropathy; CRC cis rs4713118 0.869 rs9461401 chr6:27703291 G/A cg06470822 chr6:28175283 NA 0.71 10.07 0.49 5.85e-21 Parkinson's disease; CRC cis rs3858526 0.642 rs10838783 chr11:5900282 T/G cg26762873 chr11:5879799 OR52E8 -0.45 -6.69 -0.35 9.75e-11 DNA methylation (variation); CRC cis rs2625529 0.617 rs2957365 chr15:72348106 C/T cg16672083 chr15:72433130 SENP8 0.47 7.06 0.36 1e-11 Red blood cell count; CRC cis rs2073300 0.609 rs6137945 chr20:23406136 C/T cg12062639 chr20:23401060 NAPB 0.84 7.64 0.39 2.34e-13 Peripheral arterial disease (traffic-related air pollution interaction); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg07238657 chr1:154973705 ZBTB7B 0.48 6.69 0.35 9.56e-11 Response to antipsychotic treatment; CRC cis rs780096 0.526 rs780106 chr2:27681598 A/C cg12000995 chr2:27665139 KRTCAP3 -0.32 -6.67 -0.35 1.1e-10 Total body bone mineral density; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg22988483 chr14:93581567 ITPK1 0.39 6.48 0.34 3.37e-10 Intelligence (multi-trait analysis); CRC cis rs10486722 0.651 rs4724070 chr7:41783359 T/C cg22138096 chr7:41772439 LOC285954 0.62 7.31 0.37 2.06e-12 Pit-and-Fissure caries; CRC cis rs853679 0.517 rs9393886 chr6:28050039 T/G cg25164649 chr6:28176230 NA 0.73 9.32 0.46 1.74e-18 Depression; CRC cis rs6964587 1.000 rs6946356 chr7:91727385 G/A cg17063962 chr7:91808500 NA 0.78 13.76 0.6 2.43e-34 Breast cancer; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg01140101 chr1:202113040 ARL8A 0.48 6.37 0.33 6.23e-10 Thyroid stimulating hormone; CRC cis rs72781680 0.898 rs17462670 chr2:24026579 T/C cg08917208 chr2:24149416 ATAD2B 0.86 8.58 0.43 3.88e-16 Lymphocyte counts; CRC cis rs2635047 0.565 rs2668759 chr18:44693711 T/C cg19077165 chr18:44547161 KATNAL2 -0.42 -6.67 -0.35 1.06e-10 Educational attainment; CRC cis rs1348850 0.561 rs57986285 chr2:178468663 C/T cg27490568 chr2:178487706 NA 0.61 7.33 0.37 1.85e-12 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs77956314 0.515 rs7302025 chr12:117442902 C/T cg25972092 chr12:117363249 FBXW8 0.53 6.38 0.33 6.02e-10 Subcortical brain region volumes;Hippocampal volume; CRC cis rs7772486 0.754 rs2064185 chr6:146066814 G/A cg13319975 chr6:146136371 FBXO30 0.48 7.12 0.37 7.01e-12 Lobe attachment (rater-scored or self-reported); CRC cis rs2839186 0.596 rs4819217 chr21:47644092 G/T cg13126279 chr21:47581558 C21orf56 -0.39 -5.92 -0.31 7.89e-9 Testicular germ cell tumor; CRC trans rs7395662 1.000 rs4882096 chr11:48534102 T/G cg21153622 chr11:89784906 NA -0.45 -7.11 -0.36 7.19e-12 HDL cholesterol; CRC cis rs1865760 1.000 rs6938233 chr6:25914077 C/T cg16482183 chr6:26056742 HIST1H1C 0.55 7.9 0.4 4.09e-14 Height; CRC cis rs6840360 0.593 rs1877185 chr4:152690348 C/T cg09659197 chr4:152720779 NA 0.41 8.6 0.43 3.34e-16 Intelligence (multi-trait analysis); CRC trans rs1455244 0.700 rs7229302 chr18:11508904 G/T cg25175469 chr15:59063261 FAM63B 0.38 6.03 0.32 4.45e-9 Schizophrenia; CRC cis rs10504229 0.683 rs7820559 chr8:58142662 C/T cg21724239 chr8:58056113 NA 0.48 6.59 0.34 1.79e-10 Developmental language disorder (linguistic errors); CRC cis rs7618915 1.000 rs34569561 chr3:52287293 T/C cg15147215 chr3:52552868 STAB1 -0.53 -7.72 -0.39 1.38e-13 Bipolar disorder; CRC cis rs11250464 0.833 rs11250466 chr10:1409378 C/T cg26394196 chr10:1453818 ADARB2 -0.33 -5.94 -0.31 7.13e-9 Radiation response; CRC cis rs589448 0.902 rs315124 chr12:69771727 G/A cg20891283 chr12:69753455 YEATS4 0.98 21.04 0.76 6.92e-63 Cerebrospinal fluid biomarker levels; CRC cis rs4688759 0.764 rs11716961 chr3:49908338 G/A cg07636037 chr3:49044803 WDR6 -0.86 -5.7 -0.3 2.7e-8 Blood protein levels; CRC cis rs9814567 0.752 rs4318591 chr3:134328333 A/G cg06109529 chr3:134205091 CEP63;ANAPC13 -0.67 -9.59 -0.47 2.23e-19 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs875971 1.000 rs7801282 chr7:65613687 C/T cg12463550 chr7:65579703 CRCP -0.48 -6.92 -0.36 2.34e-11 Aortic root size; CRC cis rs7647973 1.000 rs8897 chr3:49460407 A/G cg07636037 chr3:49044803 WDR6 0.6 7.45 0.38 8.07e-13 Menarche (age at onset); CRC cis rs3823572 0.564 rs2953621 chr7:133662403 C/G cg03336402 chr7:133662267 EXOC4 -0.67 -10.38 -0.5 5.03e-22 Intelligence (multi-trait analysis); CRC cis rs9549367 0.724 rs7985335 chr13:113869244 G/T cg18105134 chr13:113819100 PROZ 0.71 10.79 0.51 1.95e-23 Platelet distribution width; CRC trans rs6058526 1.000 rs12479832 chr20:30733863 A/G cg13674914 chr7:14429205 DGKB -0.52 -6.11 -0.32 2.88e-9 Chronic obstructive pulmonary disease; CRC trans rs7829975 0.572 rs28446104 chr8:8795901 C/G cg16141378 chr3:129829833 LOC729375 0.43 6.22 0.32 1.48e-9 Mood instability; CRC cis rs60871478 1.000 rs6460801 chr7:810506 T/C cg04727924 chr7:799746 HEATR2 -0.46 -6.72 -0.35 7.99e-11 Cerebrospinal P-tau181p levels; CRC cis rs9322193 0.962 rs2342764 chr6:150156204 G/A cg07701084 chr6:150067640 NUP43 0.57 7.87 0.4 5.3e-14 Lung cancer; CRC cis rs10751667 0.600 rs14346 chr11:1011829 T/C ch.11.42038R chr11:967971 AP2A2 0.58 9.18 0.45 5.05e-18 Alzheimer's disease (late onset); CRC trans rs1814175 0.817 rs6486044 chr11:49982718 C/T cg15704280 chr7:45808275 SEPT13 -0.97 -18.82 -0.72 3.98e-54 Height; CRC cis rs72615157 0.612 rs7786505 chr7:99817585 G/T cg00814883 chr7:100076585 TSC22D4 -0.5 -6.04 -0.32 4.14e-9 Lung function (FEV1/FVC); CRC cis rs2991971 1.000 rs518365 chr1:46010652 A/G cg15605315 chr1:45957053 TESK2 0.43 6.88 0.35 3.03e-11 High light scatter reticulocyte count; CRC cis rs9372498 0.536 rs9481808 chr6:118784571 G/A cg22561889 chr6:118971681 C6orf204 0.52 6.7 0.35 9.08e-11 Diastolic blood pressure; CRC cis rs8180040 0.764 rs6794193 chr3:47114904 T/C cg02527881 chr3:46936655 PTH1R -0.4 -7.49 -0.38 6.49e-13 Colorectal cancer; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg11251499 chr4:57774202 REST 0.41 6.06 0.32 3.7e-9 Intelligence (multi-trait analysis); CRC cis rs2797685 0.853 rs707462 chr1:7849880 A/G cg04725166 chr1:7887271 PER3 -0.45 -5.66 -0.3 3.31e-8 Crohn's disease; CRC cis rs651907 0.557 rs7651404 chr3:101393294 C/A cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.62 8.41 0.42 1.3e-15 Colorectal cancer; CRC cis rs11212617 0.967 rs228589 chr11:108093208 A/T cg01991180 chr11:108092276 ATM;NPAT 0.43 6.35 0.33 7.01e-10 Response to metformin in type 2 diabetes (glycemic); CRC cis rs7666738 0.800 rs2865987 chr4:99067852 A/C cg17366294 chr4:99064904 C4orf37 0.41 6.82 0.35 4.41e-11 Colonoscopy-negative controls vs population controls; CRC cis rs28386778 0.897 rs6504176 chr17:61811920 T/C cg22520471 chr17:61851767 DDX42;CCDC47 0.73 11.11 0.52 1.4e-24 Prudent dietary pattern; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg24506149 chr1:39339048 MYCBP 0.44 6.23 0.32 1.42e-9 Anxiety disorder; CRC cis rs9322193 0.886 rs2065663 chr6:150081467 A/G cg00933542 chr6:150070202 PCMT1 0.32 6.34 0.33 7.63e-10 Lung cancer; CRC trans rs11250098 0.548 rs7837038 chr8:10783074 G/A cg08071915 chr8:12219732 FAM66A 0.35 5.99 0.31 5.48e-9 Morning vs. evening chronotype; CRC cis rs853679 0.517 rs9380061 chr6:28132803 T/C cg12273811 chr6:28175739 NA 0.73 9.16 0.45 5.8e-18 Depression; CRC cis rs7954584 0.567 rs10840632 chr12:122375460 C/T cg21171335 chr12:122356390 WDR66 0.37 5.82 0.31 1.38e-8 Mean corpuscular volume; CRC cis rs9291683 0.620 rs717615 chr4:10104670 C/T cg00071950 chr4:10020882 SLC2A9 0.5 8.95 0.44 2.58e-17 Bone mineral density; CRC cis rs6541297 0.775 rs4846910 chr1:230291441 C/A cg05784532 chr1:230284198 GALNT2 0.48 6.07 0.32 3.43e-9 Coronary artery disease; CRC cis rs911119 0.913 rs6036463 chr20:23578940 A/T cg16589663 chr20:23618590 CST3 -0.41 -5.74 -0.3 2.21e-8 Chronic kidney disease; CRC cis rs9796 0.870 rs2925345 chr15:41311799 T/C cg18705301 chr15:41695430 NDUFAF1 0.35 5.85 0.31 1.21e-8 Menopause (age at onset); CRC cis rs1552244 0.882 rs13064570 chr3:9997545 G/C cg10729496 chr3:10149963 C3orf24 0.46 6.07 0.32 3.58e-9 Alzheimer's disease; CRC cis rs9549260 0.755 rs9549255 chr13:41235213 C/T cg21288729 chr13:41239152 FOXO1 0.49 7.64 0.39 2.43e-13 Red blood cell count; CRC cis rs10883723 0.847 rs3808934 chr10:104264280 C/T cg22532475 chr10:104410764 TRIM8 -0.37 -6.86 -0.35 3.51e-11 Allergic disease (asthma, hay fever or eczema); CRC cis rs7937682 1.000 rs10502147 chr11:111569931 G/A cg19812747 chr11:111475976 SIK2 0.54 8.48 0.42 7.7e-16 Primary sclerosing cholangitis; CRC cis rs514406 0.861 rs2477741 chr1:53265278 A/G cg25767906 chr1:53392781 SCP2 0.47 7.49 0.38 6.24e-13 Monocyte count; CRC cis rs1008375 0.931 rs979823 chr4:17700176 G/A cg16339924 chr4:17578868 LAP3 0.48 6.18 0.32 1.94e-9 Parasitemia in Tripanosoma cruzi seropositivity; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg10914544 chr1:94374370 GCLM 0.43 6.58 0.34 1.86e-10 Intelligence (multi-trait analysis); CRC cis rs7726839 0.507 rs60068988 chr5:597668 T/C cg14541582 chr5:601475 NA -0.36 -7.37 -0.38 1.42e-12 Obesity-related traits; CRC cis rs6499255 0.951 rs75815213 chr16:69702854 C/T cg15192750 chr16:69999425 NA 0.55 7.36 0.38 1.44e-12 IgE levels; CRC cis rs873946 0.648 rs1548281 chr10:134552982 C/T cg18305652 chr10:134549665 INPP5A 0.47 5.96 0.31 6.37e-9 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CRC cis rs1865760 0.613 rs9295674 chr6:25912342 A/G cg03517284 chr6:25882590 NA -0.45 -6.65 -0.34 1.21e-10 Height; CRC cis rs7208859 0.623 rs609063 chr17:28951513 A/G cg19761014 chr17:28927070 LRRC37B2 0.57 5.86 0.31 1.11e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs561341 0.739 rs1978116 chr17:30220978 A/C cg13647721 chr17:30228624 UTP6 0.59 6.93 0.36 2.19e-11 Hip circumference adjusted for BMI; CRC cis rs7659604 1.000 rs10005932 chr4:122664782 T/C cg20573242 chr4:122745356 CCNA2 0.4 6.01 0.31 4.92e-9 Type 2 diabetes; CRC cis rs1784581 0.588 rs4131681 chr6:162422167 T/G cg17173639 chr6:162384350 PARK2 0.6 9.71 0.47 9.23e-20 Itch intensity from mosquito bite; CRC cis rs12042938 0.935 rs1417585 chr1:231803604 C/T cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX 0.47 6.67 0.35 1.05e-10 Neuranatomic and neurocognitive phenotypes; CRC cis rs35306767 0.903 rs35370435 chr10:898205 T/C cg26597838 chr10:835615 NA 1.23 14.8 0.63 2.42e-38 Eosinophil percentage of granulocytes; CRC trans rs783540 0.809 rs3970696 chr15:83263756 A/T cg18393722 chr15:85113863 UBE2QP1 0.34 6.19 0.32 1.83e-9 Schizophrenia; CRC cis rs28386778 0.897 rs3744293 chr17:61841788 T/A cg22520471 chr17:61851767 DDX42;CCDC47 0.74 11.57 0.54 3.22e-26 Prudent dietary pattern; CRC cis rs28386778 0.897 rs7212196 chr17:61834981 T/C cg06601766 chr17:61851465 DDX42;CCDC47 0.44 5.97 0.31 6.12e-9 Prudent dietary pattern; CRC cis rs7666738 0.830 rs7659593 chr4:98934823 T/C cg17366294 chr4:99064904 C4orf37 0.43 7.32 0.37 1.95e-12 Colonoscopy-negative controls vs population controls; CRC cis rs1451375 0.617 rs2060763 chr7:50542359 G/A cg14593290 chr7:50529359 DDC -0.61 -8.0 -0.4 2.14e-14 Malaria; CRC cis rs739401 0.611 rs7109088 chr11:3027485 G/T cg08508325 chr11:3079039 CARS -0.5 -9.33 -0.46 1.57e-18 Longevity; CRC cis rs9527 0.590 rs10786741 chr10:104939182 G/A cg04362960 chr10:104952993 NT5C2 0.61 8.48 0.42 7.82e-16 Arsenic metabolism; CRC cis rs72634258 0.945 rs12753070 chr1:8114319 C/G cg00042356 chr1:8021962 PARK7 0.67 7.13 0.37 6.42e-12 Inflammatory bowel disease; CRC cis rs6693567 0.565 rs2264417 chr1:150368501 C/T cg15654264 chr1:150340011 RPRD2 0.43 6.52 0.34 2.68e-10 Migraine; CRC trans rs7647973 0.626 rs4855845 chr3:49687043 T/C cg21659725 chr3:3221576 CRBN -0.63 -7.03 -0.36 1.21e-11 Menarche (age at onset); CRC cis rs2019137 0.905 rs2276561 chr2:113956371 G/C cg21610815 chr2:113994035 PAX8;LOC654433;LOC440839 -0.45 -6.27 -0.33 1.11e-9 Lymphocyte counts; CRC cis rs2243480 1.000 rs316332 chr7:65604299 A/G cg18252515 chr7:66147081 NA -1.25 -14.86 -0.63 1.46e-38 Diabetic kidney disease; CRC cis rs883565 0.582 rs811969 chr3:39180162 A/C cg01426195 chr3:39028469 NA 0.41 6.61 0.34 1.6e-10 Handedness; CRC cis rs9916302 0.861 rs3889368 chr17:37683231 C/T cg07936489 chr17:37558343 FBXL20 -0.77 -11.46 -0.53 8.14e-26 Glomerular filtration rate (creatinine); CRC cis rs7715806 0.500 rs10515213 chr5:74980572 C/T cg19683494 chr5:74908142 NA -0.51 -5.8 -0.3 1.55e-8 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs78545713 0.649 rs11751062 chr6:26216165 C/T cg01420254 chr6:26195488 NA 0.67 6.0 0.31 5.2e-9 Iron status biomarkers (total iron binding capacity); CRC trans rs941408 1.000 rs1736180 chr19:2796021 C/T cg08017880 chr11:407180 SIGIRR -0.44 -6.2 -0.32 1.65e-9 Total cholesterol levels; CRC cis rs4285028 0.699 rs12629742 chr3:121614895 T/C cg11130432 chr3:121712080 ILDR1 -0.49 -6.04 -0.32 4.1e-9 Multiple sclerosis; CRC cis rs9534288 0.762 rs9534264 chr13:46541673 T/A cg15192986 chr13:46630673 CPB2 -0.68 -9.86 -0.48 2.95e-20 Blood protein levels; CRC cis rs9311676 0.656 rs55711525 chr3:58397775 C/A cg06643156 chr3:58380774 PXK 0.42 6.38 0.33 5.84e-10 Systemic lupus erythematosus; CRC cis rs4853012 0.838 rs72915068 chr2:74356185 G/A cg20891558 chr2:74357851 NA 0.67 10.41 0.5 3.9e-22 Gestational age at birth (maternal effect); CRC trans rs3780486 0.846 rs7850878 chr9:33126570 A/G cg04842962 chr6:43655489 MRPS18A 1.15 25.75 0.82 7.73e-81 IgG glycosylation; CRC cis rs10256972 0.684 rs2363279 chr7:1096143 A/G cg26608667 chr7:1196370 ZFAND2A 0.36 5.7 0.3 2.66e-8 Longevity;Endometriosis; CRC cis rs1552244 0.572 rs58223482 chr3:10169746 G/C cg18598329 chr3:10140678 FANCD2;C3orf24 -0.9 -10.73 -0.51 3.19e-23 Alzheimer's disease; CRC cis rs769267 0.965 rs1010207 chr19:19416045 T/C cg01262667 chr19:19385393 TM6SF2 0.38 6.24 0.33 1.36e-9 Tonsillectomy; CRC cis rs1336900 0.513 rs56253522 chr1:150614869 C/A cg17724175 chr1:150552817 MCL1 0.63 9.96 0.48 1.38e-20 Blood protein levels; CRC cis rs10464366 0.912 rs6979668 chr7:39104228 G/A cg18850127 chr7:39170497 POU6F2 0.5 6.43 0.33 4.42e-10 IgG glycosylation; CRC cis rs9916302 0.784 rs34473775 chr17:37396201 G/T cg15445000 chr17:37608096 MED1 0.39 8.38 0.42 1.52e-15 Glomerular filtration rate (creatinine); CRC trans rs4679956 0.511 rs55686028 chr3:151688903 C/T cg05484920 chr19:49588520 SNRNP70 0.45 6.03 0.32 4.31e-9 Male-pattern baldness; CRC cis rs55665837 1.000 rs11023246 chr11:14536956 T/C cg19336497 chr11:14380999 RRAS2 -0.4 -6.68 -0.35 1.03e-10 Vitamin D levels; CRC cis rs738322 0.967 rs133021 chr22:38573338 T/C cg25457927 chr22:38595422 NA -0.38 -7.76 -0.39 1.1e-13 Cutaneous nevi; CRC trans rs10504229 1.000 rs72650887 chr8:58177343 G/A cg04077850 chr5:125800366 GRAMD3 0.37 6.28 0.33 1.04e-9 Developmental language disorder (linguistic errors); CRC cis rs13108904 0.846 rs3775100 chr4:1225106 T/C cg19318889 chr4:1322082 MAEA 0.39 5.92 0.31 8.1e-9 Obesity-related traits; CRC cis rs1784581 0.802 rs9365355 chr6:162414604 A/G cg17173639 chr6:162384350 PARK2 0.7 11.58 0.54 3.02e-26 Itch intensity from mosquito bite; CRC cis rs1448094 0.512 rs12314318 chr12:86249238 T/C cg18827107 chr12:86230957 RASSF9 -0.45 -7.49 -0.38 6.6e-13 Major depressive disorder; CRC cis rs6424115 1.000 rs7514394 chr1:24100223 A/G cg10978503 chr1:24200527 CNR2 -0.46 -8.34 -0.42 2.09e-15 Immature fraction of reticulocytes; CRC cis rs1552244 1.000 rs113522867 chr3:10154503 T/C cg13047869 chr3:10149882 C3orf24 0.58 7.8 0.39 8.47e-14 Alzheimer's disease; CRC cis rs7726839 0.540 rs4957080 chr5:644552 A/C cg09021430 chr5:549028 NA 0.73 8.42 0.42 1.22e-15 Obesity-related traits; CRC trans rs10021731 0.718 rs7671026 chr4:115408892 C/A cg25927708 chr2:119603813 EN1 -0.33 -6.01 -0.31 4.92e-9 Optic disc area; CRC cis rs17345786 1.000 rs7641261 chr3:101279006 C/T cg11279151 chr3:101281821 RG9MTD1 -0.67 -8.26 -0.41 3.52e-15 Colonoscopy-negative controls vs population controls; CRC cis rs4727027 0.901 rs11760293 chr7:148811725 A/G cg12479418 chr7:148823350 ZNF425;ZNF398 0.44 5.9 0.31 8.97e-9 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC cis rs1577917 1.000 rs12208493 chr6:86662267 T/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.52 -6.53 -0.34 2.57e-10 Response to antipsychotic treatment; CRC cis rs7618915 0.571 rs12487445 chr3:52618319 A/C cg18099408 chr3:52552593 STAB1 -0.46 -7.53 -0.38 5e-13 Bipolar disorder; CRC cis rs9291683 0.588 rs2240722 chr4:10020757 A/G cg11266682 chr4:10021025 SLC2A9 0.54 11.42 0.53 1.19e-25 Bone mineral density; CRC cis rs6951245 0.938 rs11764937 chr7:1092074 C/T cg18402987 chr7:1209562 NA 0.63 6.74 0.35 6.94e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs17095355 0.818 rs6584970 chr10:111847820 A/G cg00817464 chr10:111662876 XPNPEP1 -0.49 -6.38 -0.33 5.92e-10 Biliary atresia; CRC cis rs6543140 1.000 rs6543140 chr2:103074274 G/T cg09003973 chr2:102972529 NA 0.41 5.83 0.31 1.33e-8 Blood protein levels; CRC cis rs9868809 0.881 rs7620853 chr3:48666503 G/A cg07636037 chr3:49044803 WDR6 -0.61 -5.73 -0.3 2.29e-8 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; CRC cis rs3091242 0.900 rs4649086 chr1:25778967 T/A cg27572855 chr1:25598939 RHD 0.35 6.08 0.32 3.31e-9 Erythrocyte sedimentation rate; CRC cis rs1153858 1.000 rs8042786 chr15:45703539 T/C cg21132104 chr15:45694354 SPATA5L1 0.59 8.46 0.42 9.02e-16 Homoarginine levels; CRC cis rs3812762 0.871 rs11603335 chr11:8809844 A/G cg00186954 chr11:8933980 ST5;C11orf17 0.39 6.52 0.34 2.7e-10 Hypospadias; CRC cis rs858239 0.965 rs156429 chr7:23306020 A/G cg00469287 chr7:23338798 C7orf30 0.45 6.14 0.32 2.41e-9 Cerebrospinal fluid biomarker levels; CRC cis rs6502050 0.835 rs35857672 chr17:80078303 G/A cg09264619 chr17:80180166 NA 0.39 6.5 0.34 3.04e-10 Life satisfaction; CRC cis rs10504229 1.000 rs67913746 chr8:58177825 A/G cg05313129 chr8:58192883 C8orf71 -0.47 -6.99 -0.36 1.49e-11 Developmental language disorder (linguistic errors); CRC trans rs11098499 0.954 rs11098526 chr4:120390359 C/T cg25214090 chr10:38739885 LOC399744 0.66 10.51 0.5 1.77e-22 Corneal astigmatism; CRC cis rs2882667 0.628 rs13171173 chr5:138042464 A/C cg09476006 chr5:138032270 NA -0.59 -9.79 -0.48 4.92e-20 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs7666738 0.830 rs7663438 chr4:99014582 C/T cg17366294 chr4:99064904 C4orf37 0.43 7.25 0.37 2.99e-12 Colonoscopy-negative controls vs population controls; CRC cis rs8060686 0.516 rs8048364 chr16:68253324 T/G cg26727032 chr16:67993705 SLC12A4 -0.63 -9.56 -0.47 2.92e-19 HDL cholesterol;Metabolic syndrome; CRC cis rs1545257 0.505 rs13016195 chr2:24634942 T/C cg06627628 chr2:24431161 ITSN2 -0.45 -6.64 -0.34 1.29e-10 Sjögren's syndrome; CRC trans rs2303319 0.504 rs1449641 chr2:162619567 T/C cg13490827 chr1:46269305 MAST2 -0.68 -5.99 -0.31 5.44e-9 Cognitive function; CRC cis rs10504229 0.683 rs7835498 chr8:58129780 A/C cg22535103 chr8:58192502 C8orf71 -0.7 -9.34 -0.46 1.47e-18 Developmental language disorder (linguistic errors); CRC trans rs17666963 0.568 rs768733 chr10:125214716 C/T cg00049729 chr5:55776345 NA 0.69 6.04 0.32 4.16e-9 Cardiac Troponin-T levels; CRC cis rs9311676 0.609 rs55646457 chr3:58415263 T/A cg06643156 chr3:58380774 PXK 0.42 6.43 0.33 4.39e-10 Systemic lupus erythematosus; CRC cis rs9611519 0.894 rs9611488 chr22:41462592 G/T cg03806693 chr22:41940476 POLR3H -0.59 -7.59 -0.39 3.22e-13 Neuroticism; CRC cis rs4819052 0.851 rs58644915 chr21:46669912 T/C cg11663144 chr21:46675770 NA -0.84 -14.44 -0.62 5.88e-37 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs782590 0.522 rs12329050 chr2:55894428 G/A cg18811423 chr2:55921094 PNPT1 -0.75 -11.78 -0.54 5.96e-27 Metabolic syndrome; CRC cis rs67340775 0.541 rs200975 chr6:27855625 G/T cg08798685 chr6:27730294 NA -0.57 -6.29 -0.33 9.95e-10 Lung cancer in ever smokers; CRC cis rs7762018 1.000 rs11961560 chr6:170130121 T/C cg17545662 chr6:170176663 C6orf70 0.56 6.45 0.34 3.94e-10 Thiazide-induced adverse metabolic effects in hypertensive patients; CRC cis rs478304 0.651 rs11604462 chr11:65551648 G/A cg27068330 chr11:65405492 SIPA1 -0.6 -8.9 -0.44 3.81e-17 Acne (severe); CRC cis rs12824058 0.831 rs55726136 chr12:130810312 G/A cg26677194 chr12:130822605 PIWIL1 0.45 7.19 0.37 4.42e-12 Menopause (age at onset); CRC cis rs911555 0.755 rs12435516 chr14:103954404 T/C cg12935359 chr14:103987150 CKB 0.56 9.11 0.45 8.32e-18 Intelligence (multi-trait analysis); CRC cis rs9372498 0.505 rs62424204 chr6:118861642 G/A cg18833306 chr6:118973337 C6orf204 0.45 5.91 0.31 8.58e-9 Diastolic blood pressure; CRC trans rs2303319 0.504 rs1449641 chr2:162619567 T/C cg23247704 chr1:116518985 SLC22A15 -0.72 -6.12 -0.32 2.7e-9 Cognitive function; CRC cis rs2742417 1.000 rs2673036 chr3:45752471 C/T cg04837898 chr3:45731254 SACM1L -0.36 -5.92 -0.31 7.95e-9 Response to anti-depressant treatment in major depressive disorder; CRC cis rs1552244 0.935 rs11926481 chr3:10142102 G/T cg13047869 chr3:10149882 C3orf24 0.53 7.43 0.38 9.64e-13 Alzheimer's disease; CRC trans rs10982213 0.830 rs2274163 chr9:117188714 C/T cg01900965 chr4:2471727 RNF4 0.42 6.29 0.33 1.02e-9 Interleukin-6 levels; CRC cis rs6582630 0.519 rs8189618 chr12:38276281 A/C cg13010199 chr12:38710504 ALG10B 0.44 5.73 0.3 2.33e-8 Drug-induced liver injury (flucloxacillin); CRC cis rs6088813 0.961 rs1886691 chr20:33986271 T/C cg14752227 chr20:34000481 UQCC -0.37 -5.74 -0.3 2.12e-8 Height; CRC cis rs7605827 0.930 rs12692260 chr2:15511809 A/G cg19274914 chr2:15703543 NA 0.38 5.8 0.3 1.59e-8 Educational attainment (years of education); CRC trans rs7395662 0.517 rs10838960 chr11:48584741 A/G cg21153622 chr11:89784906 NA -0.53 -8.82 -0.44 6.77e-17 HDL cholesterol; CRC cis rs4665809 1.000 rs6546736 chr2:26293878 C/T cg22920501 chr2:26401640 FAM59B 0.52 7.07 0.36 9.11e-12 Gut microbiome composition (summer); CRC trans rs4843747 0.636 rs4075597 chr16:88107590 C/A cg26811252 chr16:29126840 RRN3P2 0.61 7.94 0.4 3.13e-14 Menopause (age at onset); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg06061645 chr5:86708854 CCNH 0.43 6.36 0.33 6.93e-10 Intelligence (multi-trait analysis); CRC cis rs12135062 0.755 rs1553287 chr1:3101277 G/A cg00254258 chr1:3105189 PRDM16 -0.57 -9.51 -0.46 4.07e-19 Migraine; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg27095527 chr3:12329080 PPARG 0.4 6.18 0.32 1.85e-9 Intelligence (multi-trait analysis); CRC cis rs9611565 0.512 rs964898 chr22:42142306 C/T cg17554472 chr22:41940697 POLR3H -0.55 -5.78 -0.3 1.77e-8 Vitiligo; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg03892937 chr1:67395684 MIER1 0.44 6.42 0.33 4.76e-10 Intelligence (multi-trait analysis); CRC cis rs11098499 0.954 rs13113483 chr4:120309039 C/T cg24375607 chr4:120327624 NA 0.51 7.86 0.4 5.5e-14 Corneal astigmatism; CRC cis rs3741404 0.791 rs11603192 chr11:63927695 A/G cg18225595 chr11:63971243 STIP1 0.64 10.8 0.51 1.78e-23 Platelet count; CRC cis rs6860806 0.631 rs7736284 chr5:131588151 T/C cg18758796 chr5:131593413 PDLIM4 0.45 8.23 0.41 4.3e-15 Breast cancer; CRC trans rs35110281 0.667 rs4819286 chr21:45120121 G/A cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.42 6.85 0.35 3.65e-11 Mean corpuscular volume; CRC cis rs9309473 0.632 rs7599076 chr2:73585519 G/T cg20560298 chr2:73613845 ALMS1 -0.49 -6.76 -0.35 6.44e-11 Metabolite levels; CRC cis rs9903692 0.954 rs12450620 chr17:46130254 G/T cg21215337 chr17:46176117 CBX1 0.43 7.83 0.4 6.68e-14 Pulse pressure; CRC cis rs57221529 0.766 rs12521051 chr5:560440 A/G cg09021430 chr5:549028 NA 0.72 8.14 0.41 8.31e-15 Lung disease severity in cystic fibrosis; CRC cis rs4363385 0.747 rs1415961 chr1:152973464 G/A cg25856811 chr1:152973957 SPRR3 -0.26 -7.22 -0.37 3.62e-12 Inflammatory skin disease; CRC cis rs2233152 0.611 rs28660501 chr19:41300277 G/T cg21869046 chr19:41225005 ITPKC 0.35 5.67 0.3 3.07e-8 Kawasaki disease; CRC cis rs929354 0.772 rs3802118 chr7:156986814 T/C cg16102536 chr7:156981717 UBE3C 0.4 6.77 0.35 5.77e-11 Body mass index; CRC cis rs6674176 0.597 rs4031031 chr1:44393533 C/T cg12908607 chr1:44402522 ARTN -0.57 -10.11 -0.49 4.18e-21 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Cognitive ability; CRC trans rs9956878 0.555 rs8085188 chr18:73544676 A/G cg15434853 chr3:52570586 NT5DC2;LOC440957 -0.38 -6.15 -0.32 2.24e-9 Obesity-related traits; CRC cis rs6570726 0.577 rs867056 chr6:145784805 A/C cg23711669 chr6:146136114 FBXO30 -0.61 -9.11 -0.45 8.15e-18 Lobe attachment (rater-scored or self-reported); CRC cis rs12143943 0.866 rs10458588 chr1:204505487 T/C cg17419461 chr1:204415978 PIK3C2B 0.39 5.99 0.31 5.43e-9 Cognitive performance; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg02931271 chr19:49947035 NA 0.41 5.97 0.31 6.26e-9 Intelligence (multi-trait analysis); CRC cis rs897984 0.542 rs59061704 chr16:31062704 G/C cg02466173 chr16:30829666 NA -0.59 -8.92 -0.44 3.29e-17 Dementia with Lewy bodies; CRC cis rs68170813 0.559 rs12538090 chr7:106974647 T/C cg02696742 chr7:106810147 HBP1 -0.57 -6.22 -0.32 1.53e-9 Coronary artery disease; CRC cis rs10504229 1.000 rs66870803 chr8:58180022 G/C cg24829409 chr8:58192753 C8orf71 -0.68 -11.34 -0.53 2.27e-25 Developmental language disorder (linguistic errors); CRC cis rs684232 0.666 rs461521 chr17:622497 G/T cg15660573 chr17:549704 VPS53 -0.7 -12.31 -0.56 6.51e-29 Prostate cancer; CRC cis rs2404602 0.608 rs12439484 chr15:76602937 A/C cg03037974 chr15:76606532 NA 0.81 15.83 0.66 2.33e-42 Blood metabolite levels; CRC cis rs11030122 0.547 rs10767723 chr11:3955026 G/T cg18678763 chr11:4115507 RRM1 -0.39 -6.61 -0.34 1.59e-10 Mean platelet volume;Platelet distribution width; CRC cis rs769267 0.895 rs2965183 chr19:19545696 G/A cg02546618 chr19:19431379 KIAA0892;SF4 0.46 6.43 0.33 4.47e-10 Tonsillectomy; CRC cis rs910316 0.712 rs175074 chr14:75504454 G/A cg03030879 chr14:75389066 RPS6KL1 0.45 7.16 0.37 5.34e-12 Height; CRC cis rs653465 0.739 rs1522151 chr3:27165174 C/T cg02860705 chr3:27208620 NA 0.35 5.67 0.3 3.19e-8 Breast cancer (early onset); CRC cis rs3750082 0.889 rs7785065 chr7:32915204 C/A cg05721444 chr7:32995514 FKBP9 0.51 7.87 0.4 5.33e-14 Glomerular filtration rate (creatinine); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg02998992 chr17:19265610 B9D1 0.4 6.21 0.32 1.57e-9 Intelligence (multi-trait analysis); CRC cis rs924607 0.898 rs1697990 chr5:626278 A/G cg04221910 chr5:616842 CEP72 -0.4 -6.61 -0.34 1.57e-10 Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg01494303 chr16:3508002 NAT15 0.44 6.25 0.33 1.27e-9 Anxiety disorder; CRC cis rs35264875 1.000 rs7110274 chr11:68842704 A/G cg23740940 chr11:68924746 NA 0.44 5.65 0.3 3.48e-8 Blond vs. brown hair color; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg19654209 chr19:13976743 NA 0.45 6.29 0.33 1.01e-9 Anxiety disorder; CRC cis rs4713118 0.621 rs4713134 chr6:28034121 T/C cg02683197 chr6:28174875 NA 0.72 8.85 0.44 5.44e-17 Parkinson's disease; CRC cis rs1799949 0.965 rs8176193 chr17:41231516 C/T cg23758822 chr17:41437982 NA 0.82 13.89 0.61 7.63e-35 Menopause (age at onset); CRC cis rs9894429 0.550 rs6565617 chr17:79612333 G/A cg21028142 chr17:79581711 NPLOC4 0.34 7.09 0.36 8.14e-12 Eye color traits; CRC trans rs9393777 0.720 rs13217285 chr6:26999845 C/T cg06606381 chr12:133084897 FBRSL1 -0.88 -6.69 -0.35 9.64e-11 Intelligence (multi-trait analysis); CRC cis rs6543140 0.964 rs13393175 chr2:103078849 T/G cg09003973 chr2:102972529 NA 0.41 5.83 0.31 1.33e-8 Blood protein levels; CRC cis rs7208859 0.673 rs216418 chr17:28936537 G/A cg14008862 chr17:28927542 LRRC37B2 0.5 5.93 0.31 7.51e-9 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs1949733 0.666 rs3103070 chr4:8508825 A/G cg11789530 chr4:8429930 ACOX3 -0.82 -11.83 -0.55 3.93e-27 Response to antineoplastic agents; CRC cis rs9372498 0.536 rs62421536 chr6:118727972 G/A cg22561889 chr6:118971681 C6orf204 0.51 6.29 0.33 1.04e-9 Diastolic blood pressure; CRC cis rs55702914 0.742 rs34555121 chr2:198166053 C/T cg10820045 chr2:198174542 NA 0.47 8.79 0.44 8.67e-17 Major depression and alcohol dependence; CRC cis rs172166 0.516 rs1225618 chr6:28129713 A/C cg02683197 chr6:28174875 NA 0.47 6.61 0.34 1.53e-10 Cardiac Troponin-T levels; CRC cis rs7584330 0.504 rs11891426 chr2:238434702 T/G cg16989719 chr2:238392110 NA -0.34 -5.87 -0.31 1.06e-8 Prostate cancer; CRC cis rs9747201 1.000 rs3922470 chr17:80110159 C/T cg09264619 chr17:80180166 NA 0.51 7.31 0.37 1.99e-12 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs12971120 1.000 rs2278162 chr18:72175814 A/G cg26446133 chr18:72167187 CNDP2 -0.77 -12.22 -0.56 1.44e-28 Refractive error; CRC cis rs4713118 0.869 rs4713121 chr6:27722064 T/C cg15845792 chr6:28175446 NA 0.69 8.58 0.43 3.72e-16 Parkinson's disease; CRC cis rs2153535 0.580 rs9378554 chr6:8488468 C/T cg21535247 chr6:8435926 SLC35B3 0.5 7.51 0.38 5.54e-13 Motion sickness; CRC cis rs853679 0.517 rs9357065 chr6:28129580 T/C cg25164649 chr6:28176230 NA 0.78 9.65 0.47 1.48e-19 Depression; CRC cis rs28386778 0.863 rs2727288 chr17:61901197 T/A cg06873352 chr17:61820015 STRADA 0.77 14.46 0.62 5e-37 Prudent dietary pattern; CRC cis rs7412746 0.658 rs11581757 chr1:150892244 A/G cg15448220 chr1:150897856 SETDB1 0.55 8.04 0.41 1.64e-14 Melanoma; CRC cis rs9902453 1.000 rs4575590 chr17:28361969 C/G cg26525008 chr17:28256777 EFCAB5;SSH2 -0.59 -8.86 -0.44 4.95e-17 Coffee consumption (cups per day); CRC cis rs67311347 1.000 rs11720360 chr3:40448397 G/A cg09455208 chr3:40491958 NA 0.47 8.99 0.44 2.03e-17 Renal cell carcinoma; CRC cis rs6860806 0.507 rs270601 chr5:131656997 T/C cg24060327 chr5:131705240 SLC22A5 -0.52 -7.65 -0.39 2.17e-13 Breast cancer; CRC cis rs1163251 0.902 rs627707 chr1:120217133 C/G cg19096424 chr1:120255104 PHGDH 0.46 6.65 0.34 1.2e-10 Blood metabolite levels; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg07951519 chr17:4607306 PELP1 0.49 6.9 0.36 2.62e-11 Response to antipsychotic treatment; CRC cis rs2580764 0.565 rs2919129 chr2:55216545 G/T cg09592903 chr2:55203963 RTN4 0.71 11.59 0.54 2.9e-26 Mean platelet volume; CRC cis rs3617 0.539 rs4687689 chr3:52948674 A/C cg07507251 chr3:52567010 NT5DC2 -0.39 -6.17 -0.32 1.99e-9 Red blood cell count;Autism spectrum disorder or schizophrenia; CRC cis rs57994353 0.760 rs4413892 chr9:139330158 G/A cg13611204 chr9:139324423 INPP5E -0.42 -5.87 -0.31 1.08e-8 Eosinophil counts;Cutaneous squamous cell carcinoma; CRC cis rs11971779 0.680 rs7801613 chr7:139039927 A/G cg23387468 chr7:139079360 LUC7L2 -0.41 -7.02 -0.36 1.28e-11 Diisocyanate-induced asthma; CRC cis rs7552404 0.924 rs7546641 chr1:76158035 T/C cg10523679 chr1:76189770 ACADM 0.93 14.17 0.62 6.79e-36 Blood metabolite levels;Acylcarnitine levels; CRC cis rs447 1.000 rs7783472 chr7:83751882 G/A cg22846510 chr7:83753280 SEMA3A -0.6 -7.79 -0.39 8.91e-14 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg04626574 chr22:26879726 HPS4;SRRD 0.47 6.1 0.32 2.99e-9 Thyroid stimulating hormone; CRC cis rs4243830 1.000 rs12047931 chr1:6587614 C/T cg05709478 chr1:6581295 PLEKHG5 0.67 5.73 0.3 2.23e-8 Body mass index; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg08616681 chr16:718778 RHOT2 0.45 6.19 0.32 1.75e-9 Thyroid stimulating hormone; CRC cis rs11971779 0.680 rs6962186 chr7:139034806 T/C cg07862535 chr7:139043722 LUC7L2 0.59 7.58 0.39 3.47e-13 Diisocyanate-induced asthma; CRC cis rs1218582 0.772 rs1109815 chr1:154909268 A/G cg24250549 chr1:154909240 PMVK 0.64 10.9 0.51 8.28e-24 Prostate cancer; CRC cis rs4713675 0.525 rs622917 chr6:33702869 C/T cg14003231 chr6:33640908 ITPR3 -0.36 -5.92 -0.31 8.27e-9 Plateletcrit; CRC cis rs780096 0.546 rs1104 chr2:27599875 T/G cg12648201 chr2:27665141 KRTCAP3 -0.29 -5.75 -0.3 1.99e-8 Total body bone mineral density; CRC cis rs2976388 0.647 rs2082801 chr8:143786461 A/G cg24046110 chr8:143859143 LYNX1 0.46 7.97 0.4 2.7e-14 Urinary tract infection frequency; CRC cis rs2979489 0.591 rs62508371 chr8:30422060 C/T cg26383811 chr8:30366931 RBPMS -0.66 -10.06 -0.49 6.11e-21 Mean corpuscular hemoglobin;Plateletcrit;Neutrophil count;Granulocyte count;Sum basophil neutrophil counts;Mean corpuscular volume;Myeloid white cell count;Sum neutrophil eosinophil counts; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg20390613 chr1:12678355 DHRS3 0.46 6.54 0.34 2.38e-10 Response to antipsychotic treatment; CRC cis rs1218582 0.772 rs6686873 chr1:154913404 C/G cg06221963 chr1:154839813 KCNN3 -0.75 -14.96 -0.64 5.77e-39 Prostate cancer; CRC cis rs875971 0.662 rs448725 chr7:65514628 A/G cg11764359 chr7:65958608 NA 0.57 9.02 0.45 1.58e-17 Aortic root size; CRC trans rs526631 0.564 rs10896051 chr11:65578759 C/T cg17712092 chr4:129076599 LARP1B -0.52 -7.97 -0.4 2.61e-14 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; CRC cis rs4919694 1.000 rs11191525 chr10:104793435 G/C cg04362960 chr10:104952993 NT5C2 1.17 10.78 0.51 2.08e-23 Arsenic metabolism; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg16003301 chr12:56521951 ESYT1 0.45 6.15 0.32 2.22e-9 Anxiety disorder; CRC cis rs561341 1.000 rs55962687 chr17:30260369 C/T cg12193833 chr17:30244370 NA -0.72 -8.27 -0.41 3.45e-15 Hip circumference adjusted for BMI; CRC cis rs6973256 0.637 rs12539993 chr7:133418799 C/T cg10665199 chr7:133106180 EXOC4 0.46 7.32 0.37 1.97e-12 Intelligence (multi-trait analysis); CRC cis rs7737355 0.947 rs7725220 chr5:130877001 C/G cg06307176 chr5:131281290 NA 0.44 6.45 0.34 3.9e-10 Life satisfaction; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg02760007 chr6:43139670 SRF 0.4 6.17 0.32 2e-9 Liver disease severity in Alagille syndrome; CRC cis rs9487051 1.000 rs7748918 chr6:109613564 A/G cg01475377 chr6:109611718 NA -0.44 -7.7 -0.39 1.58e-13 Reticulocyte fraction of red cells; CRC cis rs7044106 0.762 rs1324473 chr9:123404610 C/T cg09419670 chr9:123605666 PSMD5;LOC253039 -0.71 -11.69 -0.54 1.18e-26 Hip circumference adjusted for BMI; CRC cis rs6088580 0.634 rs4911423 chr20:32999386 T/A cg24642439 chr20:33292090 TP53INP2 -0.37 -6.31 -0.33 8.83e-10 Glomerular filtration rate (creatinine); CRC trans rs7937682 0.602 rs11214036 chr11:111773169 C/T cg18187862 chr3:45730750 SACM1L 0.43 5.97 0.31 6.29e-9 Primary sclerosing cholangitis; CRC cis rs11190604 1.000 rs7100386 chr10:102301417 C/T cg07080220 chr10:102295463 HIF1AN 0.47 5.66 0.3 3.31e-8 Palmitoleic acid (16:1n-7) levels; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg20237707 chr13:111719772 NA 0.43 7.38 0.38 1.31e-12 Liver disease severity in Alagille syndrome; CRC cis rs6693567 0.565 rs10888584 chr1:150476406 C/G cg15654264 chr1:150340011 RPRD2 0.41 6.1 0.32 3.03e-9 Migraine; CRC trans rs2303319 0.504 rs62188988 chr2:162531068 T/C cg05972502 chr5:132073061 KIF3A -0.7 -6.01 -0.31 5.01e-9 Cognitive function; CRC cis rs11122272 0.735 rs2790873 chr1:231539685 A/G cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.57 -8.51 -0.42 6.05e-16 Hemoglobin concentration; CRC cis rs4319547 0.695 rs1803290 chr12:122865029 T/C cg05707623 chr12:122985044 ZCCHC8 0.75 9.14 0.45 6.52e-18 Body mass index; CRC cis rs172166 0.637 rs1071893 chr6:28167635 G/C cg20615401 chr6:28092323 ZSCAN16 0.42 5.61 0.3 4.21e-8 Cardiac Troponin-T levels; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg04108127 chr1:222885781 AIDA;C1orf58 0.42 6.08 0.32 3.39e-9 Intelligence (multi-trait analysis); CRC cis rs1971762 0.545 rs10783585 chr12:53977317 T/G cg06632207 chr12:54070931 ATP5G2 0.39 6.58 0.34 1.82e-10 Height; CRC cis rs4870684 1.000 rs4870684 chr7:57699151 C/T cg01314568 chr7:57830625 NA -0.65 -8.88 -0.44 4.48e-17 Bipolar disorder and schizophrenia; CRC cis rs12286929 0.802 rs12787954 chr11:115020328 T/C cg04055981 chr11:115044050 NA 0.38 6.14 0.32 2.33e-9 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs617791 0.530 rs7934543 chr11:65752508 G/T cg09783858 chr11:65769428 EIF1AD;BANF1 0.49 7.31 0.37 2.1e-12 Breast cancer; CRC cis rs13191362 1.000 rs13195226 chr6:163006421 A/G cg23758597 chr6:163146217 PARK2 -0.51 -5.91 -0.31 8.33e-9 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs9457247 1.000 rs2149090 chr6:167372764 T/C cg23791538 chr6:167370224 RNASET2 0.39 6.1 0.32 2.93e-9 Crohn's disease; CRC cis rs4689388 0.926 rs10937717 chr4:6295087 T/A cg25554036 chr4:6271136 WFS1 0.51 8.22 0.41 4.63e-15 Type 2 diabetes and other traits;Type 2 diabetes; CRC cis rs9372498 0.536 rs12333080 chr6:118845410 A/C cg15382696 chr6:118971807 C6orf204 0.61 8.01 0.4 2.07e-14 Diastolic blood pressure; CRC cis rs10911390 0.793 rs12041487 chr1:183591550 C/A cg11505048 chr1:183622726 RGL1;APOBEC4 0.76 6.93 0.36 2.16e-11 Systemic lupus erythematosus; CRC cis rs2777491 0.574 rs1757468 chr15:41743574 T/A cg18705301 chr15:41695430 NDUFAF1 -1.12 -20.53 -0.75 7.34e-61 Ulcerative colitis; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg22633390 chr7:100964966 RABL5 0.38 6.15 0.32 2.25e-9 Liver disease severity in Alagille syndrome; CRC cis rs1801251 0.896 rs7573208 chr2:233696701 C/A cg25237894 chr2:233734115 C2orf82 -0.44 -7.11 -0.37 7.05e-12 Coronary artery disease; CRC trans rs11098499 0.909 rs10026736 chr4:120384322 G/C cg25214090 chr10:38739885 LOC399744 0.66 10.32 0.49 7.91e-22 Corneal astigmatism; CRC cis rs853679 0.517 rs1853097 chr6:28058635 A/G cg03623178 chr6:28175578 NA 0.96 12.48 0.57 1.62e-29 Depression; CRC cis rs3741404 0.825 rs2845597 chr11:63954370 G/A cg05016508 chr11:63871570 FLRT1;MACROD1 0.42 6.39 0.33 5.69e-10 Platelet count; CRC cis rs7827545 1.000 rs1372659 chr8:135566779 T/A cg13086574 chr8:135490821 ZFAT -0.37 -6.26 -0.33 1.19e-9 Hypertension (SNP x SNP interaction); CRC cis rs9527 0.615 rs36045108 chr10:104697929 G/A cg15744005 chr10:104629667 AS3MT -0.31 -6.23 -0.32 1.41e-9 Arsenic metabolism; CRC cis rs4803468 0.967 rs4605279 chr19:41888131 C/G cg09537434 chr19:41945824 ATP5SL -0.94 -18.01 -0.7 5.8e-51 Height; CRC cis rs10504229 0.683 rs16921843 chr8:58113338 T/C cg05313129 chr8:58192883 C8orf71 -0.43 -6.0 -0.31 5.07e-9 Developmental language disorder (linguistic errors); CRC cis rs6964587 0.934 rs4512319 chr7:91733829 G/A cg17063962 chr7:91808500 NA 0.75 11.16 0.52 9.55e-25 Breast cancer; CRC cis rs7618915 0.547 rs6768697 chr3:52703615 C/T cg10802521 chr3:52805072 NEK4 -0.58 -8.85 -0.44 5.34e-17 Bipolar disorder; CRC cis rs1624802 0.966 rs1707933 chr12:130497813 T/G cg15444478 chr12:130494697 NA -0.29 -5.98 -0.31 5.85e-9 Obesity-related traits; CRC cis rs5769765 1.000 rs761879 chr22:50241210 G/A cg04121214 chr22:50244548 NA -0.42 -6.11 -0.32 2.84e-9 Schizophrenia; CRC cis rs13191362 1.000 rs60719662 chr6:163006643 A/C cg23758597 chr6:163146217 PARK2 -0.51 -5.91 -0.31 8.33e-9 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC trans rs2303319 0.504 rs56026147 chr2:162614089 T/C cg11326919 chr17:43324904 LOC100133991 -0.64 -5.97 -0.31 5.99e-9 Cognitive function; CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg13108601 chr6:41748242 FRS3;PRICKLE4 -0.54 -6.63 -0.34 1.41e-10 Diisocyanate-induced asthma; CRC cis rs9372253 0.678 rs9487392 chr6:110708626 C/T cg01119278 chr6:110721349 DDO 0.39 6.18 0.32 1.87e-9 Platelet distribution width; CRC cis rs2398668 0.570 rs4721548 chr7:2330496 A/G cg08027265 chr7:2291960 NA -0.42 -6.85 -0.35 3.63e-11 Bipolar disorder and schizophrenia; CRC cis rs9611565 0.659 rs12483786 chr22:41938536 A/G cg06481639 chr22:41940642 POLR3H -0.53 -6.07 -0.32 3.43e-9 Vitiligo; CRC trans rs2727020 0.521 rs11040408 chr11:49534880 A/T cg15704280 chr7:45808275 SEPT13 0.76 10.4 0.5 4.3e-22 Coronary artery disease; CRC cis rs7772486 0.754 rs10872580 chr6:146140281 C/T cg23711669 chr6:146136114 FBXO30 -0.73 -12.89 -0.58 4.62e-31 Lobe attachment (rater-scored or self-reported); CRC cis rs6141769 0.542 rs6057630 chr20:31318737 A/G cg13636640 chr20:31349939 DNMT3B -0.37 -5.73 -0.3 2.32e-8 Subjective well-being; CRC cis rs17433780 0.964 rs10493821 chr1:89475135 C/T cg09516651 chr1:89888402 LOC400759 0.48 7.28 0.37 2.46e-12 Carotid intima media thickness; CRC cis rs2398893 1.000 rs12004383 chr9:96826239 G/T cg14459158 chr9:96720562 NA 0.48 7.59 0.39 3.23e-13 Waist-hip ratio;Waist-to-hip ratio adjusted for body mass index; CRC trans rs12478296 0.792 rs6740738 chr2:243007368 A/C cg18288967 chr1:45987694 PRDX1 0.56 6.39 0.33 5.51e-10 Obesity-related traits; CRC cis rs473651 0.935 rs1103770 chr2:239339281 G/C cg18131467 chr2:239335373 ASB1 0.87 14.08 0.61 1.47e-35 Multiple system atrophy; CRC cis rs1368882 0.814 rs1702020 chr1:55105728 C/T cg01517571 chr1:55089959 ACOT11;FAM151A 0.54 7.15 0.37 5.81e-12 Non-substance related behavioral disinhibition; CRC cis rs10769945 0.834 rs217207 chr11:1974831 G/A cg23202291 chr11:1979235 NA -0.45 -6.57 -0.34 1.96e-10 DNA methylation (variation); CRC cis rs6988985 0.765 rs62525057 chr8:143976023 T/C cg10324643 chr8:143916377 GML 0.38 6.24 0.33 1.38e-9 Plasma androstenedione levels in resected early stage-receptor positive breast cancer; CRC cis rs7618915 0.571 rs2251219 chr3:52584787 C/T cg10802521 chr3:52805072 NEK4 0.57 8.72 0.43 1.43e-16 Bipolar disorder; CRC cis rs1552244 1.000 rs56270432 chr3:10087517 G/C cg02579736 chr3:10068473 FANCD2;CIDECP 0.96 12.92 0.58 3.51e-31 Alzheimer's disease; CRC cis rs727563 0.569 rs73178647 chr22:41964168 G/A cg03806693 chr22:41940476 POLR3H -1.08 -12.6 -0.57 5.83e-30 Crohn's disease;Inflammatory bowel disease; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg13603510 chr19:3626908 C19orf29 0.38 6.08 0.32 3.26e-9 Liver disease severity in Alagille syndrome; CRC cis rs7587476 0.784 rs17424051 chr2:215688992 G/C cg04004882 chr2:215674386 BARD1 0.66 9.25 0.45 2.92e-18 Neuroblastoma; CRC trans rs9388451 0.657 rs4895799 chr6:126052729 C/T cg05039488 chr6:79577232 IRAK1BP1 -0.49 -7.52 -0.38 5.14e-13 Brugada syndrome; CRC cis rs4718428 0.705 rs12536410 chr7:66254290 G/A cg18252515 chr7:66147081 NA -0.54 -7.37 -0.38 1.4e-12 Corneal structure; CRC trans rs877282 0.898 rs11253349 chr10:765897 C/G cg22713356 chr15:30763199 NA 1.3 15.02 0.64 3.32e-39 Uric acid levels; CRC cis rs5753618 0.539 rs5997933 chr22:31672752 A/C cg22777020 chr22:31556080 RNF185 -0.51 -5.76 -0.3 1.92e-8 Colorectal cancer; CRC cis rs7493 1.000 rs12026 chr7:95041016 G/C cg01874867 chr7:94954059 PON1 -0.49 -6.25 -0.33 1.27e-9 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs561341 1.000 rs4795670 chr17:30244839 T/C cg23018236 chr17:30244563 NA -0.46 -6.2 -0.32 1.68e-9 Hip circumference adjusted for BMI; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg09133386 chr6:20404188 E2F3 0.48 6.81 0.35 4.77e-11 Response to antipsychotic treatment; CRC cis rs3820068 0.580 rs34426856 chr1:16006315 C/T cg24675056 chr1:15929824 NA 0.52 7.06 0.36 9.92e-12 Systolic blood pressure; CRC cis rs9914988 0.943 rs4794836 chr17:27082710 C/G cg16670446 chr17:27188758 MIR451;MIR144 -0.59 -10.38 -0.5 4.89e-22 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs9906944 0.933 rs12945020 chr17:47082775 G/A cg09029085 chr17:47094198 IGF2BP1 0.3 5.66 0.3 3.31e-8 Intelligence (multi-trait analysis);Body fat percentage; CRC cis rs875971 0.638 rs6960778 chr7:66071597 C/T cg25985355 chr7:65971099 NA 0.32 5.69 0.3 2.76e-8 Aortic root size; CRC cis rs6840360 0.642 rs1470280 chr4:152431770 C/T cg09659197 chr4:152720779 NA 0.33 6.69 0.35 9.61e-11 Intelligence (multi-trait analysis); CRC cis rs1008375 0.966 rs3796812 chr4:17582051 G/A cg16339924 chr4:17578868 LAP3 0.62 8.22 0.41 4.83e-15 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs12980942 0.872 rs11879562 chr19:41804976 C/G cg25627403 chr19:41769009 HNRNPUL1 0.45 5.61 0.3 4.39e-8 Coronary artery disease; CRC cis rs7923609 0.740 rs10761784 chr10:65308750 A/T cg08743896 chr10:65200160 JMJD1C -0.4 -5.71 -0.3 2.58e-8 Educational attainment;Liver enzyme levels (alkaline phosphatase); CRC cis rs10946940 0.965 rs6915266 chr6:27528643 G/A cg21251018 chr6:28226885 NKAPL -0.4 -6.27 -0.33 1.11e-9 Systemic lupus erythematosus; CRC trans rs1814175 0.817 rs12277258 chr11:49940216 T/C cg15704280 chr7:45808275 SEPT13 -1.02 -20.57 -0.75 5.09e-61 Height; CRC cis rs921968 0.565 rs7586384 chr2:219582897 T/C cg02176678 chr2:219576539 TTLL4 -0.45 -7.09 -0.36 8.06e-12 Mean corpuscular hemoglobin concentration; CRC cis rs78456975 0.607 rs72776258 chr2:1530732 C/G cg26248373 chr2:1572462 NA -0.61 -6.42 -0.33 4.84e-10 Placebo response in major depressive disorder (% change in symptom score); CRC cis rs4713118 0.869 rs9461400 chr6:27700559 A/G cg08798685 chr6:27730294 NA -0.42 -6.26 -0.33 1.23e-9 Parkinson's disease; CRC cis rs427394 0.659 rs187295 chr5:6734326 C/T cg15145174 chr5:6755386 POLS -0.45 -6.45 -0.33 4.1e-10 Menopause (age at onset); CRC cis rs4073416 0.542 rs4902404 chr14:66047022 T/C cg03016385 chr14:66212404 NA -0.46 -6.25 -0.33 1.29e-9 N-glycan levels; CRC cis rs597539 0.652 rs516425 chr11:68715675 G/A cg06028808 chr11:68637592 NA 0.36 5.73 0.3 2.3e-8 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs10193935 0.901 rs6733914 chr2:42674741 A/G cg27598129 chr2:42591480 NA 0.69 7.95 0.4 3.05e-14 Colonoscopy-negative controls vs population controls; CRC trans rs7248779 0.512 rs7250002 chr19:2413188 A/G cg25835954 chr13:50160062 RCBTB1 0.54 8.01 0.4 1.99e-14 Cortisol levels (saliva); CRC cis rs9611565 0.918 rs7290404 chr22:41749796 C/T cg03806693 chr22:41940476 POLR3H -1.01 -13.15 -0.59 4.81e-32 Vitiligo; CRC trans rs8002861 0.641 rs4942252 chr13:44443039 C/T cg17145862 chr1:211918768 LPGAT1 0.57 9.92 0.48 1.8e-20 Leprosy; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg18737971 chr15:43941642 CATSPER2 -0.41 -6.74 -0.35 7.29e-11 Liver disease severity in Alagille syndrome; CRC cis rs7937682 0.824 rs510866 chr11:111484113 A/C cg09085632 chr11:111637200 PPP2R1B -0.98 -19.21 -0.73 1.09e-55 Primary sclerosing cholangitis; CRC trans rs1590305 0.786 rs3764077 chr13:38059067 A/G cg03965764 chr11:45248109 NA -0.59 -6.05 -0.32 3.96e-9 Hip geometry; CRC cis rs9487051 0.676 rs7753697 chr6:109593292 A/G cg21918786 chr6:109611834 NA -0.41 -7.17 -0.37 4.84e-12 Reticulocyte fraction of red cells; CRC cis rs763014 0.932 rs2384972 chr16:674424 G/A cg04562611 chr16:615315 C16orf11 0.38 6.49 0.34 3.23e-10 Height; CRC cis rs425277 0.585 rs3107157 chr1:2061969 A/G cg24578937 chr1:2090814 PRKCZ -0.4 -7.26 -0.37 2.73e-12 Height; CRC cis rs57221529 0.766 rs4245972 chr5:578572 A/G cg16447950 chr5:562315 NA -0.83 -10.81 -0.51 1.71e-23 Lung disease severity in cystic fibrosis; CRC cis rs9926296 0.585 rs6500450 chr16:89858024 A/G cg03388025 chr16:89894329 SPIRE2 0.42 8.48 0.42 7.81e-16 Vitiligo; CRC cis rs611744 0.647 rs1584373 chr8:109263399 C/A cg21045802 chr8:109455806 TTC35 0.42 6.63 0.34 1.41e-10 Dupuytren's disease; CRC cis rs6860806 0.507 rs272854 chr5:131688017 C/T cg22638593 chr5:131593259 PDLIM4 0.39 6.47 0.34 3.47e-10 Breast cancer; CRC cis rs6582630 0.555 rs11182193 chr12:38474090 C/G cg26384229 chr12:38710491 ALG10B 0.72 10.09 0.49 4.78e-21 Drug-induced liver injury (flucloxacillin); CRC cis rs780094 0.500 rs1919127 chr2:27801493 T/C cg27432699 chr2:27873401 GPN1 0.47 6.03 0.32 4.47e-9 Calcium levels;Fasting blood insulin;Metabolic traits;Triglyceride levels;Fasting plasma glucose;Urate levels in overweight individuals;Urate levels in obese individuals;Uric acid levels;Height;Age-related diseases, mortality and associated endophenotypes;Renal underexcretion gout;Fasting blood glucose (BMI interaction);Urate levels;Gondoic acid (20:1n-9) levels;Fasting blood insulin (BMI interaction);Triglycerides;Plasma omega-3 polyunsaturated fatty acid levels (docosapentaenoic acid);Type 2 diabetes;Nonalcoholic fatty liver disease;Hypertriglyceridemia;C-reactive protein;Age-related disease endophenotypes;LDL cholesterol;Metabolic syndrome;Crohn's disease;Alcohol consumption (drinks per week);Homeostasis model assessment of insulin resistance;Alcohol consumption;Red blood cell count;Fasting blood glucose; CRC trans rs9929218 0.551 rs2296408 chr16:68713823 A/C cg04657470 chr2:198365150 HSPE1;HSPD1 -1.2 -30.69 -0.86 1.43e-98 Colorectal cancer; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg20614940 chr2:191273670 MFSD6 0.5 6.41 0.33 5.11e-10 Thyroid stimulating hormone; CRC cis rs6429082 0.715 rs2291687 chr1:235594182 A/G cg26050004 chr1:235667680 B3GALNT2 -0.46 -6.18 -0.32 1.93e-9 Adiposity; CRC cis rs3862260 0.509 rs10754416 chr1:120163531 A/G cg16322792 chr1:120165303 ZNF697 0.45 7.93 0.4 3.34e-14 Systemic lupus erythematosus; CRC trans rs944990 0.595 rs10123378 chr9:96375217 C/T cg19764421 chr1:228783274 DUSP5P 0.4 6.11 0.32 2.75e-9 Body mass index; CRC cis rs10208940 0.764 rs34744266 chr2:68782606 G/A cg12452813 chr2:68675892 NA 0.47 5.9 0.31 9.19e-9 Urate levels in lean individuals; CRC cis rs1218582 0.772 rs906593 chr1:154885255 G/A cg06221963 chr1:154839813 KCNN3 -0.76 -15.38 -0.65 1.3e-40 Prostate cancer; CRC cis rs9522267 0.535 rs7339347 chr13:112237920 C/T cg26182253 chr13:112236782 NA 0.31 6.28 0.33 1.07e-9 Hepatitis; CRC cis rs10256972 0.630 rs13235747 chr7:1129123 T/C cg07092213 chr7:1199455 ZFAND2A -0.41 -5.78 -0.3 1.77e-8 Longevity;Endometriosis; CRC cis rs11214589 0.905 rs2186799 chr11:113242533 G/T cg14159747 chr11:113255604 NA 0.59 11.57 0.54 3.37e-26 Neuroticism; CRC cis rs7666738 0.830 rs13101766 chr4:98957696 C/A cg05340658 chr4:99064831 C4orf37 0.61 9.54 0.47 3.45e-19 Colonoscopy-negative controls vs population controls; CRC cis rs651907 0.535 rs2290859 chr3:101525625 C/T cg11279151 chr3:101281821 RG9MTD1 -0.52 -7.11 -0.36 7.44e-12 Colorectal cancer; CRC cis rs9611565 0.918 rs2281333 chr22:41749630 T/C cg03806693 chr22:41940476 POLR3H -0.72 -10.28 -0.49 1.07e-21 Vitiligo; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg19784910 chr11:101785671 KIAA1377;ANGPTL5 0.43 5.99 0.31 5.44e-9 Anxiety disorder; CRC cis rs1443512 0.796 rs1822437 chr12:54340077 A/G cg17410650 chr12:54324560 NA 0.33 5.82 0.31 1.37e-8 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for BMI in non-smokers;Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction);Waist-hip ratio;Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour); CRC cis rs713587 0.967 rs10182458 chr2:25150641 A/G cg04586622 chr2:25135609 ADCY3 -0.44 -7.82 -0.4 7.26e-14 Body mass index in non-asthmatics; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg23507024 chr3:14166481 TMEM43;CHCHD4 0.46 6.48 0.34 3.3e-10 Response to antipsychotic treatment; CRC cis rs2252790 1.000 rs1204853 chr6:116577113 A/G cg18764771 chr6:116381957 FRK 0.22 5.81 0.31 1.48e-8 Fast beta electroencephalogram; CRC trans rs7395662 0.591 rs7483212 chr11:48607182 T/A cg21153622 chr11:89784906 NA -0.53 -8.8 -0.44 8.03e-17 HDL cholesterol; CRC cis rs10193935 0.901 rs222488 chr2:42648570 T/G cg27598129 chr2:42591480 NA -0.62 -7.4 -0.38 1.14e-12 Colonoscopy-negative controls vs population controls; CRC cis rs28386778 0.897 rs11079510 chr17:61820902 T/C cg00280220 chr17:61926910 NA 0.33 5.64 0.3 3.6e-8 Prudent dietary pattern; CRC cis rs763121 0.853 rs6001214 chr22:39149155 C/T cg06022373 chr22:39101656 GTPBP1 0.79 11.93 0.55 1.68e-27 Menopause (age at onset); CRC cis rs9427116 0.502 rs3766922 chr1:154577055 A/C cg17218026 chr1:154582156 ADAR 0.62 10.47 0.5 2.39e-22 Blood protein levels; CRC cis rs7772486 0.790 rs2814879 chr6:146201743 T/C cg23711669 chr6:146136114 FBXO30 0.68 11.48 0.53 7.17e-26 Lobe attachment (rater-scored or self-reported); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg12366118 chr12:62860687 MON2 0.48 7.07 0.36 9.31e-12 Response to antipsychotic treatment; CRC trans rs7647973 0.592 rs6774202 chr3:49687779 T/G cg21659725 chr3:3221576 CRBN -0.63 -7.19 -0.37 4.36e-12 Menarche (age at onset); CRC trans rs1814175 0.645 rs866427 chr11:49923853 G/A cg11707556 chr5:10655725 ANKRD33B -0.52 -9.95 -0.48 1.49e-20 Height; CRC cis rs8180040 0.726 rs1869871 chr3:47023948 C/T cg27129171 chr3:47204927 SETD2 0.64 10.06 0.48 6.41e-21 Colorectal cancer; CRC cis rs12145833 0.538 rs12026408 chr1:243366805 G/A cg02356786 chr1:243265016 LOC731275 0.75 5.61 0.3 4.32e-8 Obesity (early onset extreme); CRC cis rs992157 0.672 rs2382829 chr2:219184617 G/A cg04880052 chr2:219191631 PNKD 0.4 6.1 0.32 3.01e-9 Colorectal cancer; CRC cis rs9322193 0.847 rs62439808 chr6:149950826 C/T cg07701084 chr6:150067640 NUP43 0.53 7.79 0.39 8.62e-14 Lung cancer; CRC cis rs1559088 0.600 rs7246566 chr19:33589618 A/T cg17764715 chr19:33622953 WDR88 0.45 6.45 0.33 4.02e-10 Bone ultrasound measurement (broadband ultrasound attenuation); CRC cis rs28386778 0.897 rs2584626 chr17:61903179 A/G cg06873352 chr17:61820015 STRADA 0.77 14.46 0.62 5e-37 Prudent dietary pattern; CRC cis rs7737355 0.773 rs31239 chr5:130813377 G/T cg25547332 chr5:131281432 NA -0.36 -5.88 -0.31 1.02e-8 Life satisfaction; CRC cis rs12505749 0.542 rs12646890 chr4:57355262 T/C cg06922635 chr4:57371607 ARL9 -0.54 -5.7 -0.3 2.66e-8 Airflow obstruction; CRC cis rs654950 0.783 rs640688 chr1:42001831 A/G cg06885757 chr1:42089581 HIVEP3 -0.34 -5.9 -0.31 9.12e-9 Airway imaging phenotypes; CRC cis rs28386778 0.897 rs3785572 chr17:61829989 C/T cg11494091 chr17:61959527 GH2 0.6 10.28 0.49 1.13e-21 Prudent dietary pattern; CRC cis rs3768617 0.811 rs6674729 chr1:183059143 C/T ch.1.3577855R chr1:183094577 LAMC1 0.63 9.36 0.46 1.24e-18 Fuchs's corneal dystrophy; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg24984818 chr19:7600102 PNPLA6 0.44 6.07 0.32 3.53e-9 Response to antipsychotic treatment; CRC cis rs1448094 0.872 rs7305869 chr12:86440114 A/G cg02569458 chr12:86230093 RASSF9 0.39 6.61 0.34 1.6e-10 Major depressive disorder; CRC cis rs9322193 0.962 rs35031906 chr6:149998574 T/C cg13206674 chr6:150067644 NUP43 0.56 8.11 0.41 1.04e-14 Lung cancer; CRC cis rs10751667 0.643 rs7396767 chr11:938808 G/A ch.11.42038R chr11:967971 AP2A2 0.6 10.27 0.49 1.24e-21 Alzheimer's disease (late onset); CRC cis rs6752107 1.000 rs3792112 chr2:234176609 C/T cg07618928 chr2:234183455 ATG16L1;SCARNA5 0.67 11.55 0.54 3.83e-26 Crohn's disease;Inflammatory bowel disease; CRC cis rs9894429 0.527 rs7405469 chr17:79566596 G/C cg21028142 chr17:79581711 NPLOC4 -0.34 -6.15 -0.32 2.23e-9 Eye color traits; CRC cis rs1801251 1.000 rs2100053 chr2:233719516 G/T cg25237894 chr2:233734115 C2orf82 -0.54 -8.75 -0.43 1.09e-16 Coronary artery disease; CRC cis rs863345 0.565 rs2220633 chr1:158445272 A/G cg12129480 chr1:158549410 OR10X1 -0.28 -5.85 -0.31 1.17e-8 Pneumococcal bacteremia; CRC cis rs9611565 0.512 rs5758436 chr22:42124265 C/T cg06634786 chr22:41940651 POLR3H 0.64 7.32 0.37 1.94e-12 Vitiligo; CRC cis rs11677416 1.000 rs4848300 chr2:113527906 T/C cg06156847 chr2:113672199 IL1F7 -0.4 -6.03 -0.32 4.46e-9 Response to antipsychotic treatment in schizophrenia (working memory); CRC cis rs7615952 0.741 rs13314845 chr3:125644782 C/T cg05084668 chr3:125655381 ALG1L -0.61 -9.32 -0.46 1.8e-18 Blood pressure (smoking interaction); CRC trans rs2303319 0.504 rs62187652 chr2:162468033 C/G cg18122310 chr12:50236657 BCDIN3D -0.73 -6.17 -0.32 2.02e-9 Cognitive function; CRC trans rs1656966 1.000 rs1656966 chr3:186466252 C/T cg10964577 chr17:15160725 PMP22 0.4 6.18 0.32 1.91e-9 Myopia (pathological); CRC cis rs1008375 1.000 rs1121089 chr4:17676476 C/A cg16339924 chr4:17578868 LAP3 0.5 6.55 0.34 2.27e-10 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs12760731 0.720 rs12047646 chr1:178274083 G/A cg00404053 chr1:178313656 RASAL2 1.11 11.41 0.53 1.29e-25 Obesity-related traits; CRC cis rs1568889 0.838 rs4572130 chr11:28371794 T/C cg06544937 chr11:28130018 METT5D1;KIF18A 0.92 15.01 0.64 3.85e-39 Bipolar disorder; CRC cis rs9522267 0.535 rs11069900 chr13:112233285 G/A cg14352298 chr13:112236639 NA 0.29 6.64 0.34 1.3100000000000001e-10 Hepatitis; CRC cis rs35123781 0.696 rs13154510 chr5:139071301 A/C cg10513866 chr5:139070639 NA 0.55 8.68 0.43 1.91e-16 Schizophrenia; CRC cis rs853679 0.517 rs9468286 chr6:28079428 C/T cg21251018 chr6:28226885 NKAPL 0.48 6.19 0.32 1.84e-9 Depression; CRC cis rs11166927 0.548 rs9324514 chr8:140830241 A/G cg16909799 chr8:140841666 TRAPPC9 0.46 7.09 0.36 8.3e-12 Pediatric non-alcoholic fatty liver disease activity score; CRC cis rs2806561 1.000 rs2806563 chr1:23506625 C/T cg12483005 chr1:23474871 LUZP1 -0.38 -5.62 -0.3 4.16e-8 Height; CRC cis rs7954584 0.813 rs11043288 chr12:122451187 C/T cg21171335 chr12:122356390 WDR66 -0.39 -5.77 -0.3 1.87e-8 Mean corpuscular volume; CRC cis rs4713118 0.955 rs9380011 chr6:27683924 A/G cg20933634 chr6:27740509 NA 0.57 8.08 0.41 1.24e-14 Parkinson's disease; CRC cis rs501120 0.584 rs11238889 chr10:44668724 G/A cg09554077 chr10:44749378 NA 0.73 8.06 0.41 1.38e-14 Coronary artery disease;Coronary heart disease; CRC cis rs10504229 1.000 rs73607871 chr8:58173007 T/C cg02725872 chr8:58115012 NA -0.38 -6.43 -0.33 4.44e-10 Developmental language disorder (linguistic errors); CRC cis rs231513 0.911 rs231511 chr17:41966335 T/C cg26893861 chr17:41843967 DUSP3 -0.7 -6.36 -0.33 6.72e-10 Cognitive function; CRC trans rs853679 0.546 rs175597 chr6:27810626 T/C cg16898833 chr6:26189333 HIST1H4D 0.72 6.45 0.34 4.06e-10 Depression; CRC cis rs7072216 0.691 rs3829853 chr10:100171174 A/G cg26618903 chr10:100175079 PYROXD2 -0.55 -8.99 -0.44 2.03e-17 Metabolite levels; CRC cis rs7927771 0.524 rs4752796 chr11:47841862 A/G cg20307385 chr11:47447363 PSMC3 -0.46 -6.74 -0.35 7.09e-11 Subjective well-being; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg18452149 chr3:108308268 KIAA1524;DZIP3 0.4 6.85 0.35 3.74e-11 Liver disease severity in Alagille syndrome; CRC cis rs6424115 0.692 rs573361 chr1:24053674 A/T cg10978503 chr1:24200527 CNR2 0.44 7.45 0.38 8.06e-13 Immature fraction of reticulocytes; CRC cis rs9768139 0.733 rs921617 chr7:158118198 A/G cg06219351 chr7:158114137 PTPRN2 -0.55 -8.34 -0.42 2.11e-15 Calcium levels; CRC cis rs1218582 0.772 rs11264282 chr1:154867370 G/A cg03351412 chr1:154909251 PMVK 0.54 8.65 0.43 2.36e-16 Prostate cancer; CRC trans rs7395662 0.517 rs2021248 chr11:49013054 C/T cg21153622 chr11:89784906 NA -0.55 -9.21 -0.45 4.02e-18 HDL cholesterol; CRC cis rs546131 0.928 rs550313 chr11:34830919 C/T cg11058730 chr11:34937778 PDHX;APIP 0.44 6.33 0.33 8.19e-10 Lung disease severity in cystic fibrosis; CRC cis rs12545109 1.000 rs2217957 chr8:57313360 T/C cg09654669 chr8:57350985 NA -0.45 -7.1 -0.36 7.95e-12 Obesity-related traits; CRC cis rs208520 0.545 rs10944874 chr6:66752080 C/T cg07460842 chr6:66804631 NA -1.08 -19.92 -0.74 1.81e-58 Exhaled nitric oxide output; CRC cis rs7107174 1.000 rs7113042 chr11:78035832 C/T cg02023728 chr11:77925099 USP35 -0.46 -8.18 -0.41 6.32e-15 Testicular germ cell tumor; CRC cis rs1552244 0.882 rs13084194 chr3:10031492 T/A cg16606324 chr3:10149918 C3orf24 0.59 7.13 0.37 6.53e-12 Alzheimer's disease; CRC cis rs3857067 0.967 rs1355240 chr4:95019353 C/T cg11021082 chr4:95130006 SMARCAD1 -0.4 -6.06 -0.32 3.63e-9 QT interval; CRC cis rs6570726 0.935 rs9390329 chr6:145828026 T/C cg23711669 chr6:146136114 FBXO30 0.68 12.0 0.55 9.22e-28 Lobe attachment (rater-scored or self-reported); CRC cis rs67311347 0.911 rs6776044 chr3:40377503 T/G cg09455208 chr3:40491958 NA 0.45 8.98 0.44 2.08e-17 Renal cell carcinoma; CRC cis rs17270561 0.609 rs12529272 chr6:25731342 A/G cg16482183 chr6:26056742 HIST1H1C 0.83 10.58 0.5 1.07e-22 Iron status biomarkers; CRC cis rs117623576 0.941 rs7924082 chr10:32429126 A/G cg03047570 chr10:32398778 NA 0.64 6.39 0.33 5.75e-10 Anti-saccade response; CRC cis rs6461049 0.519 rs3778992 chr7:2175313 C/G cg02951883 chr7:2050386 MAD1L1 -0.4 -6.47 -0.34 3.64e-10 Schizophrenia; CRC cis rs7412746 0.658 rs57818453 chr1:150763139 G/A cg10589385 chr1:150898437 SETDB1 0.31 6.34 0.33 7.79e-10 Melanoma; CRC cis rs7554547 0.765 rs6541010 chr1:11973842 A/G cg13216073 chr1:12042593 MFN2 0.4 5.76 0.3 1.89e-8 Nonsyndromic cleft lip with cleft palate; CRC cis rs7503807 0.935 rs7215534 chr17:78612119 C/T cg09596252 chr17:78655493 RPTOR 0.39 6.0 0.31 5.21e-9 Obesity; CRC cis rs2072499 0.966 rs2842865 chr1:156159532 G/A cg25208724 chr1:156163844 SLC25A44 1.1 26.81 0.83 9.1200000000000006e-85 Testicular germ cell tumor; CRC cis rs10979 1.000 rs9496671 chr6:143884742 G/A cg25407410 chr6:143891975 LOC285740 -0.79 -12.87 -0.58 5.35e-31 Hypospadias; CRC cis rs17253792 0.822 rs113649689 chr14:56088065 G/A cg01858014 chr14:56050164 KTN1 -0.87 -7.23 -0.37 3.34e-12 Putamen volume; CRC trans rs6703335 0.870 rs10803142 chr1:243598234 A/G cg08080985 chr9:77703079 C9orf95;OSTF1 0.46 6.49 0.34 3.12e-10 Schizophrenia;Schizophrenia, schizoaffective disorder or bipolar disorder; CRC cis rs172166 0.694 rs203877 chr6:28048624 T/C cg06470822 chr6:28175283 NA 0.81 12.09 0.55 4.31e-28 Cardiac Troponin-T levels; CRC cis rs10504229 0.683 rs11786527 chr8:58131344 G/C cg02725872 chr8:58115012 NA -0.62 -10.81 -0.51 1.63e-23 Developmental language disorder (linguistic errors); CRC cis rs4481887 0.741 rs6421453 chr1:248533285 A/G cg00666640 chr1:248458726 OR2T12 0.43 7.64 0.39 2.34e-13 Common traits (Other); CRC cis rs1552244 0.882 rs113268531 chr3:10167069 A/G cg16606324 chr3:10149918 C3orf24 0.71 9.42 0.46 7.95e-19 Alzheimer's disease; CRC cis rs7539542 0.556 rs10732292 chr1:202891366 T/C cg19681188 chr1:202830198 LOC148709 0.45 6.57 0.34 1.94e-10 Mean platelet volume; CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg25756398 chr11:93474621 C11orf54;TAF1D 0.43 6.78 0.35 5.42e-11 Obesity-related traits; CRC cis rs11997175 0.583 rs7464599 chr8:33817572 G/A cg04338863 chr8:33670619 NA 0.45 6.6 0.34 1.63e-10 Body mass index; CRC trans rs11650494 0.908 rs9907478 chr17:47395729 C/T cg11430096 chr6:110968061 CDK19 0.67 5.98 0.31 5.74e-9 Prostate cancer; CRC cis rs68170813 0.559 rs74898466 chr7:107053998 C/A cg02696742 chr7:106810147 HBP1 -0.52 -5.75 -0.3 1.99e-8 Coronary artery disease; CRC cis rs654950 0.806 rs10749832 chr1:42041806 C/T cg06885757 chr1:42089581 HIVEP3 0.5 8.42 0.42 1.19e-15 Airway imaging phenotypes; CRC cis rs10540 1.000 rs35068485 chr11:466032 A/T cg11503833 chr11:492997 NA 0.56 5.89 0.31 9.64e-9 Body mass index; CRC cis rs4969178 0.641 rs4969141 chr17:76391653 C/T cg02319466 chr17:76381040 PGS1 0.38 5.96 0.31 6.53e-9 HDL cholesterol levels; CRC cis rs2013441 1.000 rs2703815 chr17:20118499 C/T cg13482628 chr17:19912719 NA 0.39 5.94 0.31 7.2e-9 Obesity-related traits; CRC cis rs6964587 0.934 rs7798973 chr7:91588360 G/A cg17063962 chr7:91808500 NA 0.81 14.2 0.62 4.88e-36 Breast cancer; CRC cis rs3087591 0.639 rs734403 chr17:29723346 T/C cg24425628 chr17:29625626 OMG;NF1 0.68 12.15 0.56 2.62e-28 Hip circumference; CRC cis rs9875589 0.509 rs1873005 chr3:14060223 G/A cg14375111 chr3:14165186 TMEM43;CHCHD4 0.41 6.13 0.32 2.5e-9 Ovarian reserve; CRC cis rs6732160 0.588 rs10192654 chr2:73370882 A/T cg01422370 chr2:73384389 NA -0.39 -6.18 -0.32 1.91e-9 Intelligence (multi-trait analysis); CRC cis rs7289126 1.000 rs5756986 chr22:38640841 A/G cg25457927 chr22:38595422 NA -0.33 -6.39 -0.33 5.6e-10 Mammographic density (dense area);Percent mammographic density; CRC cis rs9925964 0.967 rs1549293 chr16:31141993 C/T cg10396673 chr16:31104726 VKORC1 0.34 5.64 0.3 3.76e-8 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs8180040 1.000 rs295461 chr3:47368010 T/C cg27129171 chr3:47204927 SETD2 0.56 8.86 0.44 5.26e-17 Colorectal cancer; CRC cis rs11971779 0.838 rs58074268 chr7:139108925 C/T cg07862535 chr7:139043722 LUC7L2 0.84 10.74 0.51 2.84e-23 Diisocyanate-induced asthma; CRC cis rs9640161 0.636 rs56190213 chr7:150025720 T/C cg12556325 chr7:150026731 C7orf29;LRRC61 -0.5 -7.04 -0.36 1.11e-11 Blood protein levels;Circulating chemerin levels; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg27537453 chr16:2732578 KCTD5 0.46 6.67 0.35 1.11e-10 Response to antipsychotic treatment; CRC cis rs727505 0.909 rs1031957 chr7:124627301 T/C cg23710748 chr7:124431027 NA -0.81 -13.96 -0.61 4.07e-35 Lewy body disease; CRC cis rs7945705 0.818 rs1988708 chr11:8882893 C/A cg12365402 chr11:9010492 NRIP3 -0.49 -8.3 -0.42 2.69e-15 Hemoglobin concentration; CRC cis rs9611565 0.592 rs4822038 chr22:41958495 G/A cg06634786 chr22:41940651 POLR3H -0.71 -7.68 -0.39 1.89e-13 Vitiligo; CRC cis rs13191362 1.000 rs13214516 chr6:163121583 A/T cg23758597 chr6:163146217 PARK2 -0.66 -6.66 -0.34 1.17e-10 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs1707322 0.682 rs12041197 chr1:46104464 T/C cg06784218 chr1:46089804 CCDC17 0.65 12.37 0.56 3.93e-29 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs10927875 0.757 rs4661679 chr1:16321010 C/T cg22431228 chr1:16359049 CLCNKA -0.32 -6.34 -0.33 7.37e-10 Dilated cardiomyopathy; CRC cis rs7568458 0.777 rs12473819 chr2:85773061 A/G cg02493740 chr2:85810744 VAMP5 -0.4 -6.36 -0.33 6.93e-10 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); CRC cis rs2228479 0.850 rs2286393 chr16:89809548 C/A cg06558623 chr16:89946397 TCF25 1.16 11.02 0.52 3.04e-24 Skin colour saturation; CRC cis rs6089584 0.854 rs6061407 chr20:60622048 A/C cg23262073 chr20:60523788 NA -0.45 -7.07 -0.36 9.51e-12 Body mass index; CRC cis rs9311474 0.569 rs7614981 chr3:52566914 G/T cg10802521 chr3:52805072 NEK4 -0.4 -6.32 -0.33 8.46e-10 Electroencephalogram traits; CRC cis rs11628318 0.660 rs4906242 chr14:103085063 G/A cg23071808 chr14:103021642 NA -0.64 -7.25 -0.37 2.99e-12 Platelet count; CRC cis rs6831352 0.842 rs1230156 chr4:99989626 C/T cg13256891 chr4:100009986 ADH5 0.55 7.36 0.38 1.5e-12 Alcohol dependence; CRC cis rs4731207 0.698 rs1904975 chr7:124552802 C/T cg23710748 chr7:124431027 NA -0.37 -6.0 -0.31 5.3300000000000004e-09 Cutaneous malignant melanoma; CRC cis rs7940866 0.804 rs3910266 chr11:130814272 A/C cg12179176 chr11:130786555 SNX19 0.64 9.28 0.46 2.39e-18 Schizophrenia; CRC cis rs4853012 0.838 rs4563249 chr2:74354016 G/T cg01017244 chr2:74357527 NA 0.68 9.29 0.46 2.23e-18 Gestational age at birth (maternal effect); CRC cis rs2032447 0.898 rs807205 chr6:26075035 C/G cg26028573 chr6:26043587 HIST1H2BB 0.45 6.62 0.34 1.47e-10 Intelligence (multi-trait analysis); CRC cis rs2070677 0.542 rs7086127 chr10:135393731 T/C cg16964102 chr10:135390573 NA 0.53 7.44 0.38 8.92e-13 Gout; CRC cis rs8062405 1.000 rs62036657 chr16:28844365 G/A cg08761264 chr16:28874980 SH2B1 -0.42 -5.64 -0.3 3.73e-8 Cognitive ability (multi-trait analysis);Cognitive ability; CRC cis rs9322193 0.962 rs4869730 chr6:150129323 A/G cg07701084 chr6:150067640 NUP43 0.48 6.8 0.35 5.05e-11 Lung cancer; CRC cis rs4925325 0.741 rs6142886 chr20:60511190 A/G cg12751644 chr20:60527061 NA 0.47 7.63 0.39 2.5e-13 Obesity-related traits; CRC cis rs4713118 0.621 rs10484403 chr6:28033523 A/G cg06470822 chr6:28175283 NA 0.97 13.12 0.59 6.28e-32 Parkinson's disease; CRC cis rs4363385 0.747 rs1415962 chr1:152958731 T/C cg25856811 chr1:152973957 SPRR3 -0.26 -7.28 -0.37 2.43e-12 Inflammatory skin disease; CRC cis rs6541297 0.941 rs2144299 chr1:230280366 A/G cg20703242 chr1:230279135 GALNT2 0.48 6.64 0.34 1.3100000000000001e-10 Coronary artery disease; CRC cis rs7072216 0.763 rs9787550 chr10:100169051 C/T cg26618903 chr10:100175079 PYROXD2 -0.55 -9.26 -0.45 2.73e-18 Metabolite levels; CRC cis rs1538970 0.962 rs9429160 chr1:45827968 G/T cg05343316 chr1:45956843 TESK2 0.69 9.24 0.45 3.18e-18 Platelet count; CRC cis rs11098499 0.954 rs10006877 chr4:120242793 C/T cg24375607 chr4:120327624 NA 0.48 7.3 0.37 2.22e-12 Corneal astigmatism; CRC cis rs8060686 0.641 rs12599880 chr16:68152035 A/G cg26727032 chr16:67993705 SLC12A4 -0.57 -6.38 -0.33 6.16e-10 HDL cholesterol;Metabolic syndrome; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg16515820 chr3:114866447 ZBTB20 0.42 6.25 0.33 1.24e-9 Intelligence (multi-trait analysis); CRC cis rs12893668 0.572 rs4906350 chr14:104111794 C/T cg01849466 chr14:104193079 ZFYVE21 -0.41 -6.11 -0.32 2.75e-9 Reticulocyte count; CRC cis rs9611565 0.512 rs9611672 chr22:42209922 A/G cg17554472 chr22:41940697 POLR3H -0.56 -5.73 -0.3 2.23e-8 Vitiligo; CRC cis rs780096 0.526 rs2010087 chr2:27637235 C/T cg27432699 chr2:27873401 GPN1 -0.56 -8.63 -0.43 2.75e-16 Total body bone mineral density; CRC cis rs2116941 1.000 rs8104426 chr19:10338676 G/T cg01850179 chr19:10340795 S1PR2 0.73 10.64 0.51 6.62e-23 Pulse pressure; CRC cis rs4862750 0.957 rs1030381 chr4:187903568 G/C cg03452623 chr4:187889614 NA -0.95 -22.1 -0.77 5.46e-67 Lobe attachment (rater-scored or self-reported); CRC cis rs7786808 0.552 rs2878456 chr7:158182129 A/T cg09998033 chr7:158218633 PTPRN2 -0.55 -7.44 -0.38 8.78e-13 Obesity-related traits; CRC cis rs3820068 0.705 rs72645808 chr1:15870118 G/C cg27534772 chr1:16042836 PLEKHM2 0.42 6.71 0.35 8.76e-11 Systolic blood pressure; CRC cis rs35306767 0.855 rs61830932 chr10:934183 T/C cg26597838 chr10:835615 NA 0.96 11.57 0.54 3.29e-26 Eosinophil percentage of granulocytes; CRC cis rs12594515 1.000 rs7172161 chr15:45990780 A/G cg19682013 chr15:45996608 NA 0.32 6.7 0.35 9.09e-11 Waist circumference;Weight; CRC cis rs780096 0.526 rs3845686 chr2:27655447 T/G cg27432699 chr2:27873401 GPN1 -0.61 -9.15 -0.45 5.97e-18 Total body bone mineral density; CRC trans rs9858542 0.953 rs9824092 chr3:49674147 C/G cg21665057 chr3:196295764 WDR53;FBXO45 -0.71 -9.36 -0.46 1.27e-18 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs2976388 0.507 rs7813604 chr8:143838062 G/A cg20041105 chr8:143859282 LYNX1 0.57 10.07 0.49 5.65e-21 Urinary tract infection frequency; CRC cis rs8062405 0.755 rs4787457 chr16:28555400 A/G cg16576597 chr16:28551801 NUPR1 0.55 8.26 0.41 3.49e-15 Cognitive ability (multi-trait analysis);Cognitive ability; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg16739845 chr14:92040772 C14orf184 0.42 5.96 0.31 6.5e-9 Anxiety disorder; CRC cis rs4700695 0.841 rs27569 chr5:65373419 C/T cg21114390 chr5:65439923 SFRS12 -0.48 -6.15 -0.32 2.19e-9 Facial morphology (factor 19); CRC cis rs2239547 0.563 rs2581820 chr3:53020544 A/G cg11645453 chr3:52864694 ITIH4 -0.56 -10.56 -0.5 1.25e-22 Schizophrenia; CRC cis rs72634258 0.945 rs17523802 chr1:8021740 G/A cg00042356 chr1:8021962 PARK7 0.68 8.35 0.42 1.98e-15 Inflammatory bowel disease; CRC cis rs73206853 0.764 rs57033697 chr12:110550992 G/A cg12870014 chr12:110450643 ANKRD13A 0.83 10.65 0.51 5.74e-23 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC cis rs6662572 0.737 rs7413189 chr1:46254330 G/A cg08644498 chr1:46502608 NA -0.45 -7.22 -0.37 3.58e-12 Blood protein levels; CRC cis rs728616 0.510 rs12411989 chr10:81937850 G/A cg11900509 chr10:81946545 ANXA11 -0.76 -9.35 -0.46 1.42e-18 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs951366 0.789 rs1775154 chr1:205696615 T/A cg23034840 chr1:205782522 SLC41A1 0.47 6.53 0.34 2.55e-10 Menarche (age at onset); CRC cis rs6502050 0.835 rs6502069 chr17:80112599 G/T cg25804541 chr17:80189381 SLC16A3 -0.31 -5.97 -0.31 6.08e-9 Life satisfaction; CRC cis rs7517126 1.000 rs35155714 chr1:196838929 C/A cg13682187 chr1:196946512 CFHR5 -0.36 -5.91 -0.31 8.52e-9 Blood protein levels; CRC cis rs7647973 0.587 rs10452032 chr3:49680973 G/A cg03060546 chr3:49711283 APEH 0.68 8.2 0.41 5.37e-15 Menarche (age at onset); CRC cis rs514406 0.893 rs522287 chr1:53365493 C/T cg27535305 chr1:53392650 SCP2 -0.37 -6.7 -0.35 9.3e-11 Monocyte count; CRC cis rs12760731 0.720 rs12021983 chr1:178323800 C/T cg00404053 chr1:178313656 RASAL2 0.85 10.33 0.49 7.65e-22 Obesity-related traits; CRC cis rs1865721 0.804 rs719179 chr18:73146396 A/G cg26385618 chr18:73139727 C18orf62 -0.43 -6.0 -0.31 5.11e-9 Intelligence; CRC cis rs1552244 0.882 rs17050660 chr3:10001772 A/G cg18598329 chr3:10140678 FANCD2;C3orf24 0.81 10.84 0.51 1.25e-23 Alzheimer's disease; CRC cis rs9462846 0.959 rs7750915 chr6:42882067 C/T cg02353165 chr6:42928485 GNMT 0.57 7.19 0.37 4.37e-12 Blood protein levels; CRC cis rs13256369 1.000 rs13267501 chr8:8574058 G/A cg06636001 chr8:8085503 FLJ10661 0.44 5.75 0.3 2.06e-8 Obesity-related traits; CRC cis rs10504229 0.774 rs72650880 chr8:58164727 C/T cg21724239 chr8:58056113 NA 0.75 9.54 0.47 3.22e-19 Developmental language disorder (linguistic errors); CRC cis rs2204008 0.619 rs11178987 chr12:38201258 C/T cg26384229 chr12:38710491 ALG10B -0.55 -8.14 -0.41 8.18e-15 Bladder cancer; CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg14195377 chr11:60928647 VPS37C 0.41 6.8 0.35 4.96e-11 Obesity-related traits; CRC cis rs4243830 0.649 rs11579888 chr1:6609896 G/A cg22792644 chr1:6614718 TAS1R1;NOL9 -0.81 -9.88 -0.48 2.55e-20 Body mass index; CRC cis rs769267 0.895 rs2916069 chr19:19520358 A/G cg03709012 chr19:19516395 GATAD2A 0.72 11.45 0.53 8.76e-26 Tonsillectomy; CRC cis rs2549003 1.000 rs2070724 chr5:131822072 A/G cg02551604 chr5:131831745 NA -0.54 -8.34 -0.42 2e-15 Asthma (sex interaction); CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg01400952 chr12:122460473 BCL7A 0.48 6.58 0.34 1.81e-10 Anxiety disorder; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg22491225 chr15:41136499 SPINT1 0.45 6.16 0.32 2.11e-9 Anxiety disorder; CRC cis rs514406 0.505 rs405208 chr1:53176674 C/T cg25767906 chr1:53392781 SCP2 -0.39 -5.98 -0.31 5.75e-9 Monocyte count; CRC cis rs909674 0.818 rs5750833 chr22:39843091 C/A cg05872129 chr22:39784769 NA -0.49 -9.14 -0.45 6.82e-18 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; CRC cis rs4713675 0.584 rs4713661 chr6:33674174 C/A cg14003231 chr6:33640908 ITPR3 0.47 7.41 0.38 1.09e-12 Plateletcrit; CRC cis rs7811142 0.830 rs7792525 chr7:99972122 A/G cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.94 12.66 0.57 3.53e-30 Platelet count; CRC cis rs4731207 0.724 rs6953168 chr7:124506341 C/T cg23710748 chr7:124431027 NA -0.38 -6.08 -0.32 3.42e-9 Cutaneous malignant melanoma; CRC cis rs477895 0.653 rs11601577 chr11:63928574 C/T cg18225595 chr11:63971243 STIP1 0.59 7.85 0.4 5.72e-14 Mean platelet volume; CRC cis rs4474465 0.850 rs10899552 chr11:78262262 G/A cg27205649 chr11:78285834 NARS2 0.49 6.4 0.33 5.23e-10 Alzheimer's disease (survival time); CRC cis rs1862618 0.853 rs832569 chr5:56154584 T/A cg20203395 chr5:56204925 C5orf35 -0.73 -8.6 -0.43 3.41e-16 Initial pursuit acceleration; CRC cis rs12580194 0.593 rs3935215 chr12:55792401 T/A cg19537932 chr12:55886519 OR6C68 -0.72 -9.22 -0.45 3.64e-18 Cancer; CRC cis rs6598955 0.585 rs6659822 chr1:26626408 C/A cg04990556 chr1:26633338 UBXN11 0.53 5.8 0.3 1.57e-8 Obesity-related traits; CRC cis rs7959452 0.536 rs4761237 chr12:69776461 C/G cg14784868 chr12:69753453 YEATS4 0.84 14.79 0.63 2.58e-38 Blood protein levels; CRC cis rs8077889 1.000 rs17742905 chr17:41891143 C/A cg25876840 chr17:41920477 NA 0.62 8.91 0.44 3.57e-17 Triglycerides; CRC cis rs1448094 0.511 rs11610371 chr12:86163487 A/G cg25456477 chr12:86230367 RASSF9 0.37 6.16 0.32 2.13e-9 Major depressive disorder; CRC cis rs1552244 0.882 rs66559400 chr3:10012551 G/A cg08888203 chr3:10149979 C3orf24 0.62 8.32 0.42 2.36e-15 Alzheimer's disease; CRC cis rs9488822 0.676 rs873879 chr6:116391259 A/G cg05304507 chr6:116381966 FRK 0.31 8.38 0.42 1.56e-15 Cholesterol, total;LDL cholesterol; CRC cis rs6460942 0.591 rs62451461 chr7:12355480 G/A cg06484146 chr7:12443880 VWDE -0.56 -5.82 -0.31 1.39e-8 Coronary artery disease; CRC cis rs9916302 0.851 rs677888 chr17:37461018 T/G cg00129232 chr17:37814104 STARD3 0.56 7.84 0.4 6.48e-14 Glomerular filtration rate (creatinine); CRC cis rs9463078 0.691 rs9296458 chr6:45267183 T/C cg25276700 chr6:44698697 NA -0.25 -6.01 -0.31 4.91e-9 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; CRC cis rs3091242 0.933 rs909833 chr1:25754140 C/G cg27572855 chr1:25598939 RHD 0.33 5.88 0.31 1.01e-8 Erythrocyte sedimentation rate; CRC cis rs6582630 0.538 rs8189550 chr12:38333058 T/G cg26384229 chr12:38710491 ALG10B -0.51 -7.44 -0.38 9.01e-13 Drug-induced liver injury (flucloxacillin); CRC cis rs853679 0.517 rs9380047 chr6:28037893 G/T cg03623178 chr6:28175578 NA 0.93 12.17 0.56 2.25e-28 Depression; CRC cis rs9467711 0.524 rs13216484 chr6:26762087 C/T cg16898833 chr6:26189333 HIST1H4D 1.05 7.54 0.38 4.49e-13 Autism spectrum disorder or schizophrenia; CRC cis rs17376456 0.877 rs10060160 chr5:93387879 G/A cg25358565 chr5:93447407 FAM172A 1.02 10.31 0.49 8.6e-22 Diabetic retinopathy; CRC cis rs881375 0.669 rs73541868 chr9:123639264 G/A cg09586646 chr9:123605570 PSMD5;LOC253039 0.39 5.68 0.3 3e-8 Rheumatoid arthritis; CRC cis rs28386778 0.863 rs3760252 chr17:61852186 G/C cg06873352 chr17:61820015 STRADA 0.77 14.43 0.62 6.45e-37 Prudent dietary pattern; CRC cis rs7605827 0.930 rs2160693 chr2:15654669 A/T cg19274914 chr2:15703543 NA 0.4 6.0 0.31 5.16e-9 Educational attainment (years of education); CRC cis rs1577917 0.837 rs10944157 chr6:86577199 A/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.5 -6.72 -0.35 7.91e-11 Response to antipsychotic treatment; CRC cis rs853679 0.517 rs9368551 chr6:28061792 A/G cg18032046 chr6:28092343 ZSCAN16 -0.5 -5.84 -0.31 1.26e-8 Depression; CRC cis rs6463523 0.815 rs66886645 chr7:763853 C/A cg05729249 chr7:766119 PRKAR1B;HEATR2 0.84 15.38 0.65 1.37e-40 Subjective well-being; CRC cis rs6684514 1.000 rs12130361 chr1:156260301 C/T cg16558208 chr1:156270281 VHLL 0.59 9.2 0.45 4.08e-18 Mean corpuscular hemoglobin concentration;Glycated hemoglobin levels; CRC cis rs9393692 0.620 rs9358918 chr6:26286744 C/T cg13736514 chr6:26305472 NA -0.43 -7.18 -0.37 4.6e-12 Educational attainment; CRC trans rs875971 0.660 rs2191268 chr7:66110224 C/T cg23591125 chr1:178481898 C1orf49 0.36 6.12 0.32 2.64e-9 Aortic root size; CRC cis rs10504229 1.000 rs59071610 chr8:58186301 A/C cg01721255 chr8:58191610 C8orf71 0.49 6.16 0.32 2.18e-9 Developmental language disorder (linguistic errors); CRC cis rs9814567 1.000 rs3932818 chr3:134206069 A/G cg06109529 chr3:134205091 CEP63;ANAPC13 -0.82 -12.25 -0.56 1.09e-28 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs7772486 0.534 rs34541797 chr6:146205304 A/G cg13319975 chr6:146136371 FBXO30 -0.62 -9.09 -0.45 9.34e-18 Lobe attachment (rater-scored or self-reported); CRC cis rs6460942 1.000 rs6944134 chr7:12418036 T/C cg10578991 chr7:12443926 VWDE -0.5 -5.95 -0.31 6.95e-9 Coronary artery disease; CRC cis rs6087990 0.806 rs1474738 chr20:31380309 G/A cg13636640 chr20:31349939 DNMT3B 0.81 15.07 0.64 2.14e-39 Ulcerative colitis; CRC cis rs720844 0.628 rs12468186 chr2:149297624 C/T cg09247360 chr2:149335327 NA -0.56 -5.83 -0.31 1.3e-8 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs873946 0.586 rs12767391 chr10:134573844 A/G cg06453172 chr10:134556979 INPP5A 0.65 7.94 0.4 3.25e-14 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg19403339 chr2:183580841 DNAJC10 0.39 6.54 0.34 2.36e-10 Liver disease severity in Alagille syndrome; CRC cis rs2075371 1.000 rs2504 chr7:133979545 A/T cg11752832 chr7:134001865 SLC35B4 0.49 7.54 0.38 4.63e-13 Mean platelet volume; CRC cis rs909002 0.962 rs7537646 chr1:32135495 G/A cg01639898 chr1:32083012 HCRTR1 0.28 5.6 0.3 4.47e-8 Intelligence (multi-trait analysis); CRC cis rs6502050 0.805 rs11651863 chr17:80084539 T/C cg25804541 chr17:80189381 SLC16A3 0.3 5.81 0.31 1.47e-8 Life satisfaction; CRC cis rs10097731 0.908 rs28550260 chr8:82025584 T/C cg25230327 chr8:82042993 NA -0.78 -10.85 -0.51 1.21e-23 Serum total protein level; CRC cis rs734999 0.588 rs6689711 chr1:2531467 T/C cg18854424 chr1:2615690 NA -0.42 -8.07 -0.41 1.3e-14 Ulcerative colitis; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg17986463 chr6:150326316 RAET1K 0.39 6.11 0.32 2.87e-9 Liver disease severity in Alagille syndrome; CRC cis rs10927875 1.000 rs4307563 chr1:16313788 C/T cg22431228 chr1:16359049 CLCNKA 0.35 5.92 0.31 7.99e-9 Dilated cardiomyopathy; CRC cis rs4713118 0.868 rs10484401 chr6:27746590 A/T cg06470822 chr6:28175283 NA -0.81 -9.21 -0.45 3.91e-18 Parkinson's disease; CRC cis rs13256369 1.000 rs12545771 chr8:8567977 C/G cg17143192 chr8:8559678 CLDN23 0.48 6.14 0.32 2.41e-9 Obesity-related traits; CRC cis rs7568498 0.564 rs9287807 chr2:161915361 T/C cg22496339 chr2:162101262 NA -0.54 -7.29 -0.37 2.26e-12 Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 3 peripheral neuropathy); CRC cis rs9399135 0.967 rs1023179 chr6:135343829 T/A cg24558204 chr6:135376177 HBS1L 0.52 8.21 0.41 5.05e-15 Red blood cell count; CRC cis rs853679 0.517 rs9393886 chr6:28050039 T/G cg02683197 chr6:28174875 NA 0.8 10.0 0.48 9.7e-21 Depression; CRC cis rs8058578 0.614 rs2878304 chr16:30878366 C/T cg02466173 chr16:30829666 NA 0.66 8.48 0.42 7.78e-16 Multiple myeloma; CRC cis rs2369473 1 rs2369473 chr1:160210727 C/A cg02974968 chr1:160236444 NA -0.47 -6.79 -0.35 5.1e-11 Squamous cell lung carcinoma; CRC cis rs7715806 0.500 rs2307115 chr5:74990348 T/C cg00601450 chr5:74908170 NA 0.49 6.08 0.32 3.26e-9 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs6504622 0.791 rs758392 chr17:45017859 C/T cg16759221 chr17:45003025 GOSR2 0.48 7.32 0.37 1.88e-12 Orofacial clefts; CRC cis rs35343117 1 rs35343117 chr15:86079115 C/G cg10818794 chr15:86012489 AKAP13 -0.44 -6.37 -0.33 6.53e-10 Psoriasis; CRC cis rs7760949 0.852 rs9349847 chr6:13927711 T/C cg27413430 chr6:13925136 RNF182 0.34 5.84 0.31 1.25e-8 Mean corpuscular hemoglobin concentration; CRC cis rs7224685 0.569 rs7215798 chr17:4007666 C/G cg09597638 chr17:3907349 NA -0.45 -5.79 -0.3 1.68e-8 Type 2 diabetes; CRC cis rs10883723 0.810 rs7074343 chr10:104283165 G/A cg22532475 chr10:104410764 TRIM8 -0.36 -6.79 -0.35 5.16e-11 Allergic disease (asthma, hay fever or eczema); CRC cis rs5753618 0.561 rs715510 chr22:31690528 T/A cg07713946 chr22:31675144 LIMK2 -0.4 -5.7 -0.3 2.61e-8 Colorectal cancer; CRC cis rs4713118 0.715 rs200480 chr6:27773664 A/G cg12172441 chr6:28176163 NA 0.52 7.23 0.37 3.42e-12 Parkinson's disease; CRC cis rs9811920 0.609 rs793466 chr3:99609837 C/T cg07805332 chr3:99536008 MIR548G;C3orf26 -0.51 -7.68 -0.39 1.84e-13 Axial length; CRC cis rs4713118 0.513 rs149951 chr6:28033087 T/C cg15786705 chr6:28176104 NA 0.59 8.5 0.42 6.86e-16 Parkinson's disease; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg02830438 chr14:93651416 C14orf109;MOAP1 0.41 5.98 0.31 5.69e-9 Intelligence (multi-trait analysis); CRC cis rs73001065 0.551 rs79954596 chr19:19548643 T/G cg03709012 chr19:19516395 GATAD2A 0.81 6.92 0.36 2.36e-11 LDL cholesterol; CRC cis rs1670533 0.932 rs3796620 chr4:1095079 A/G cg27284194 chr4:1044797 NA -0.51 -6.38 -0.33 6.11e-10 Recombination rate (females); CRC cis rs7605827 0.897 rs4140714 chr2:15515723 T/A cg19274914 chr2:15703543 NA 0.4 6.03 0.32 4.33e-9 Educational attainment (years of education); CRC cis rs910316 0.712 rs175037 chr14:75465038 T/C cg08847533 chr14:75593920 NEK9 -0.85 -14.67 -0.63 7.63e-38 Height; CRC cis rs9649213 0.593 rs10953257 chr7:97960664 A/G cg00277769 chr7:97922759 BAIAP2L1 0.6 10.35 0.5 6.46e-22 Prostate cancer (SNP x SNP interaction); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg08692210 chr3:52188851 WDR51A 0.48 7.8 0.4 8.22e-14 Liver disease severity in Alagille syndrome; CRC cis rs1003719 0.788 rs7277657 chr21:38469523 A/G cg10648535 chr21:38446584 PIGP;TTC3 0.52 7.36 0.38 1.47e-12 Eye color traits; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg00926192 chr17:42297085 UBTF -0.38 -5.99 -0.31 5.4e-9 Myopia (pathological); CRC cis rs11971779 0.553 rs10228643 chr7:139115420 G/A cg07862535 chr7:139043722 LUC7L2 0.57 7.35 0.38 1.61e-12 Diisocyanate-induced asthma; CRC cis rs4631830 0.900 rs7075009 chr10:51544143 T/G cg16070123 chr10:51489643 NA -0.35 -5.8 -0.3 1.54e-8 Prostate-specific antigen levels; CRC cis rs7945705 0.875 rs2568065 chr11:8889648 C/T cg00186954 chr11:8933980 ST5;C11orf17 -0.44 -7.14 -0.37 6.01e-12 Hemoglobin concentration; CRC trans rs3733585 0.605 rs4697926 chr4:10124567 G/T cg26043149 chr18:55253948 FECH 0.54 7.59 0.39 3.38e-13 Cleft plate (environmental tobacco smoke interaction); CRC cis rs709400 0.567 rs28496120 chr14:103897899 C/T cg12935359 chr14:103987150 CKB -0.48 -7.76 -0.39 1.11e-13 Body mass index; CRC cis rs28386778 0.863 rs2727355 chr17:61931790 C/T cg11494091 chr17:61959527 GH2 0.59 9.97 0.48 1.2e-20 Prudent dietary pattern; CRC cis rs4654899 0.802 rs7519685 chr1:21192623 G/A cg02927042 chr1:21476669 EIF4G3 -0.49 -7.83 -0.4 6.62e-14 Superior frontal gyrus grey matter volume; CRC cis rs6582630 0.555 rs11182202 chr12:38476451 C/G cg13010199 chr12:38710504 ALG10B 0.49 6.49 0.34 3.13e-10 Drug-induced liver injury (flucloxacillin); CRC cis rs2153535 0.601 rs9393030 chr6:8516489 C/G cg21535247 chr6:8435926 SLC35B3 0.5 7.69 0.39 1.77e-13 Motion sickness; CRC cis rs5753618 0.583 rs9606839 chr22:31802710 A/C cg22777020 chr22:31556080 RNF185 0.5 5.99 0.31 5.4e-9 Colorectal cancer; CRC cis rs9311474 0.607 rs4475032 chr3:52560021 C/T cg11645453 chr3:52864694 ITIH4 0.32 5.73 0.3 2.24e-8 Electroencephalogram traits; CRC trans rs4650994 0.544 rs2811306 chr1:178599248 C/G cg05059571 chr16:84539110 KIAA1609 0.6 8.19 0.41 5.65e-15 HDL cholesterol levels;HDL cholesterol; CRC trans rs17133277 0.702 rs7786415 chr7:3500105 T/G cg25123566 chr12:47610734 FAM113B;LOC100233209 -0.55 -5.99 -0.31 5.44e-9 Facial morphology (factor 5, width of mouth relative to central midface); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg12721145 chr4:109571876 OSTC 0.5 8.02 0.4 1.93e-14 Liver disease severity in Alagille syndrome; CRC cis rs5769765 0.773 rs9616383 chr22:50313014 T/C cg08270630 chr22:50330655 NA -0.4 -5.61 -0.3 4.4e-8 Schizophrenia; CRC trans rs1005277 0.579 rs2474599 chr10:38438939 A/G cg27523141 chr10:43048294 ZNF37B 0.49 7.26 0.37 2.79e-12 Extrinsic epigenetic age acceleration; CRC cis rs9611565 0.729 rs169362 chr22:41827589 G/C cg03806693 chr22:41940476 POLR3H 0.78 10.39 0.5 4.59e-22 Vitiligo; CRC trans rs7976838 0.908 rs35755432 chr12:60142506 G/A cg16974014 chr22:22007515 MIR130B 0.49 6.0 0.31 5.21e-9 Response to zileuton treatment in asthma (FEV1 change interaction); CRC cis rs9796 0.870 rs7181816 chr15:41358720 T/A cg18705301 chr15:41695430 NDUFAF1 -0.34 -5.66 -0.3 3.35e-8 Menopause (age at onset); CRC trans rs17685 0.753 rs6951943 chr7:75772452 A/G cg19862616 chr7:65841803 NCRNA00174 0.98 18.08 0.71 3.12e-51 Coffee consumption;Coffee consumption (cups per day); CRC cis rs7178572 0.568 rs1389436 chr15:77665848 G/T cg22256960 chr15:77711686 NA -0.65 -9.33 -0.46 1.56e-18 Type 2 diabetes; CRC cis rs4862750 0.914 rs6814259 chr4:187872337 T/C cg03647317 chr4:187891568 NA -0.52 -9.44 -0.46 6.84e-19 Lobe attachment (rater-scored or self-reported); CRC cis rs10256972 0.706 rs12701970 chr7:1121958 T/C cg18765753 chr7:1198926 ZFAND2A -0.35 -5.78 -0.3 1.72e-8 Longevity;Endometriosis; CRC cis rs11264799 0.598 rs72708402 chr1:157719073 C/T cg11810135 chr1:157771971 FCRL1 0.37 5.8 0.3 1.59e-8 IgA nephropathy; CRC cis rs10751667 0.714 rs7396700 chr11:963863 A/C cg06064525 chr11:970664 AP2A2 -0.3 -6.11 -0.32 2.78e-9 Alzheimer's disease (late onset); CRC trans rs10504229 0.906 rs59336968 chr8:58176857 T/C cg04077850 chr5:125800366 GRAMD3 0.37 6.27 0.33 1.15e-9 Developmental language disorder (linguistic errors); CRC cis rs10504229 0.906 rs66480865 chr8:58187100 C/T cg05313129 chr8:58192883 C8orf71 -0.47 -6.99 -0.36 1.49e-11 Developmental language disorder (linguistic errors); CRC cis rs66573146 0.572 rs67750430 chr4:6957266 T/G cg00086871 chr4:6988644 TBC1D14 0.81 8.07 0.41 1.32e-14 Granulocyte percentage of myeloid white cells; CRC cis rs7615952 0.576 rs17523380 chr3:125802874 C/T cg06494592 chr3:125709126 NA -0.53 -6.9 -0.36 2.61e-11 Blood pressure (smoking interaction); CRC cis rs7615952 0.576 rs6804482 chr3:125815762 C/T cg04553112 chr3:125709451 NA -0.54 -6.17 -0.32 1.97e-9 Blood pressure (smoking interaction); CRC cis rs4862307 0.754 rs6846007 chr4:184991604 A/G cg06737308 chr4:185021514 ENPP6 -0.45 -6.89 -0.35 2.92e-11 Serum dimethylarginine levels (asymmetric/symetric ratio); CRC trans rs9291683 0.609 rs34709913 chr4:10028955 T/C cg26043149 chr18:55253948 FECH 0.53 8.11 0.41 9.94e-15 Bone mineral density; CRC cis rs4716602 0.596 rs12386682 chr7:156158265 C/T cg16983916 chr7:156159713 NA -0.39 -6.92 -0.36 2.42e-11 Anti-saccade response; CRC cis rs2251381 0.565 rs2832279 chr21:30613466 G/T cg24692254 chr21:30365293 RNF160 0.69 10.78 0.51 2.15e-23 Selective IgA deficiency; CRC cis rs6988985 0.693 rs6395 chr8:143956808 A/C cg10324643 chr8:143916377 GML 0.36 6.16 0.32 2.08e-9 Plasma androstenedione levels in resected early stage-receptor positive breast cancer; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg27480539 chr19:16770792 TMEM38A;C19orf42 0.47 6.69 0.35 9.75e-11 Response to antipsychotic treatment; CRC cis rs6598955 0.671 rs11247900 chr1:26612460 G/A cg00852783 chr1:26633632 UBXN11 -0.49 -5.81 -0.31 1.45e-8 Obesity-related traits; CRC cis rs6500602 1.000 rs7204827 chr16:4467533 C/T cg14951292 chr16:4525986 HMOX2;NMRAL1 0.51 7.5 0.38 5.91e-13 Schizophrenia; CRC cis rs826838 0.935 rs11168761 chr12:38997211 C/A cg26384229 chr12:38710491 ALG10B 0.72 10.07 0.49 5.64e-21 Heart rate; CRC cis rs79387448 0.592 rs6728945 chr2:102986471 T/C cg09003973 chr2:102972529 NA 0.98 10.96 0.52 4.8e-24 Gut microbiota (bacterial taxa); CRC cis rs739401 0.572 rs384490 chr11:3078885 A/C cg08508325 chr11:3079039 CARS -0.53 -9.8 -0.48 4.47e-20 Longevity; CRC cis rs11229555 0.645 rs12785578 chr11:58206432 C/T cg15696309 chr11:58395628 NA -0.82 -10.45 -0.5 2.81e-22 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; CRC cis rs611744 0.550 rs1448154 chr8:109281053 T/C cg21045802 chr8:109455806 TTC35 0.44 7.03 0.36 1.18e-11 Dupuytren's disease; CRC cis rs9443645 0.810 rs10943613 chr6:79745107 C/T cg05283184 chr6:79620031 NA -0.57 -8.76 -0.43 1.04e-16 Intelligence (multi-trait analysis); CRC cis rs4665809 0.590 rs4665313 chr2:26415897 A/G cg22920501 chr2:26401640 FAM59B -0.84 -11.98 -0.55 1.05e-27 Gut microbiome composition (summer); CRC cis rs8077889 0.700 rs28571770 chr17:41904066 A/T cg16892393 chr17:41919603 NA 0.49 7.55 0.38 4.32e-13 Triglycerides; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg22627950 chr7:44622302 TMED4 0.43 6.01 0.31 5.03e-9 Response to antipsychotic treatment; CRC cis rs1799949 1.000 rs8176273 chr17:41211653 A/G cg25072359 chr17:41440525 NA 0.46 6.75 0.35 6.69e-11 Menopause (age at onset); CRC cis rs270601 0.837 rs367805 chr5:131701279 T/C cg11843238 chr5:131593191 PDLIM4 0.42 7.17 0.37 4.96e-12 Acylcarnitine levels; CRC cis rs490234 0.702 rs13285587 chr9:128233058 G/T cg14078157 chr9:128172775 NA -0.39 -6.47 -0.34 3.59e-10 Mean arterial pressure; CRC cis rs501120 0.929 rs2576354 chr10:44750393 G/A cg09554077 chr10:44749378 NA 0.87 11.81 0.55 4.65e-27 Coronary artery disease;Coronary heart disease; CRC cis rs10486722 0.583 rs2108174 chr7:41762747 T/C cg22138096 chr7:41772439 LOC285954 0.39 5.92 0.31 8.24e-9 Pit-and-Fissure caries; CRC cis rs7215564 0.818 rs36034584 chr17:78671478 A/G cg09596252 chr17:78655493 RPTOR 0.57 6.17 0.32 2.02e-9 Myopia (pathological); CRC cis rs28386778 0.830 rs2854210 chr17:61946338 C/A cg23090583 chr17:61904693 PSMC5;FTSJ3 1.03 19.6 0.73 3.2e-57 Prudent dietary pattern; CRC cis rs2072499 0.750 rs57056972 chr1:156159064 C/A cg24450063 chr1:156163899 SLC25A44 1.07 16.9 0.68 1.41e-46 Testicular germ cell tumor; CRC cis rs7590720 1.000 rs1991533 chr2:216908910 T/C cg12620499 chr2:216877984 MREG 0.83 13.39 0.59 5.99e-33 Alcohol dependence; CRC cis rs875971 1.000 rs35149210 chr7:65929925 T/C cg18912574 chr7:65842487 NCRNA00174 0.36 6.1 0.32 2.97e-9 Aortic root size; CRC cis rs929596 0.564 rs2741028 chr2:234518914 G/A cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.43 -5.7 -0.3 2.62e-8 Total bilirubin levels in HIV-1 infection; CRC cis rs763014 0.966 rs4247097 chr16:654224 G/A cg03804128 chr16:635623 NA 0.31 7.36 0.38 1.53e-12 Height; CRC cis rs4727027 0.901 rs6943937 chr7:148869915 A/G cg23583168 chr7:148888333 NA -0.86 -14.75 -0.63 3.87e-38 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC cis rs7215564 0.908 rs2315923 chr17:78693678 A/G cg09596252 chr17:78655493 RPTOR 0.62 6.6 0.34 1.65e-10 Myopia (pathological); CRC cis rs4757319 0.515 rs7116542 chr11:15436304 A/G cg03245590 chr11:15329459 NA 0.53 9.19 0.45 4.56e-18 Breast cancer; CRC cis rs911555 0.755 rs8018400 chr14:103901085 A/G cg12935359 chr14:103987150 CKB 0.56 9.13 0.45 7.33e-18 Intelligence (multi-trait analysis); CRC cis rs13108904 0.905 rs1732108 chr4:1276550 C/T cg02018176 chr4:1364513 KIAA1530 -0.48 -8.17 -0.41 6.61e-15 Obesity-related traits; CRC cis rs6840360 0.642 rs7680236 chr4:152409601 A/G cg09659197 chr4:152720779 NA 0.33 6.52 0.34 2.63e-10 Intelligence (multi-trait analysis); CRC cis rs2153535 0.580 rs7450817 chr6:8481421 G/A cg07606381 chr6:8435919 SLC35B3 0.68 10.89 0.51 8.84e-24 Motion sickness; CRC cis rs9467711 0.659 rs3823158 chr6:26463271 T/A cg16898833 chr6:26189333 HIST1H4D 1.12 8.21 0.41 5.22e-15 Autism spectrum disorder or schizophrenia; CRC cis rs6963495 0.818 rs73190189 chr7:105164452 G/A cg02135003 chr7:105160482 PUS7 -0.9 -12.2 -0.56 1.71e-28 Bipolar disorder (body mass index interaction); CRC cis rs4319547 0.695 rs55834409 chr12:122862560 C/G cg23029597 chr12:123009494 RSRC2 0.6 7.38 0.38 1.3e-12 Body mass index; CRC cis rs514406 0.893 rs2897561 chr1:53388747 C/A cg25767906 chr1:53392781 SCP2 -0.5 -8.04 -0.41 1.6e-14 Monocyte count; CRC cis rs1008375 0.797 rs6843530 chr4:17593605 G/T cg16339924 chr4:17578868 LAP3 0.57 7.66 0.39 2.14e-13 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs2933343 0.700 rs2624910 chr3:128650275 G/C cg11901034 chr3:128598214 ACAD9 -0.57 -8.31 -0.42 2.46e-15 IgG glycosylation; CRC cis rs736408 0.716 rs2300149 chr3:52822921 C/T cg10802521 chr3:52805072 NEK4 -0.54 -7.99 -0.4 2.33e-14 Bipolar disorder; CRC cis rs7618501 0.633 rs2624843 chr3:49997963 G/A cg05623727 chr3:50126028 RBM5 0.45 7.69 0.39 1.68e-13 Intelligence (multi-trait analysis); CRC cis rs1707322 0.721 rs56255771 chr1:46224319 C/T cg06784218 chr1:46089804 CCDC17 0.56 10.26 0.49 1.35e-21 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs4665809 0.627 rs35461456 chr2:26482361 C/G cg22920501 chr2:26401640 FAM59B 0.85 12.21 0.56 1.54e-28 Gut microbiome composition (summer); CRC cis rs1215050 0.740 rs11097580 chr4:98767255 C/A cg05340658 chr4:99064831 C4orf37 0.46 6.75 0.35 6.5500000000000006e-11 Waist-to-hip ratio adjusted for body mass index; CRC cis rs734999 0.588 rs6689711 chr1:2531467 T/C cg20673091 chr1:2541236 MMEL1 -0.36 -5.78 -0.3 1.76e-8 Ulcerative colitis; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg04270274 chr16:58662988 CNOT1 0.47 6.0 0.31 5.24e-9 Thyroid stimulating hormone; CRC cis rs6089584 0.821 rs2273990 chr20:60579149 G/T cg23262073 chr20:60523788 NA -0.41 -7.0 -0.36 1.49e-11 Body mass index; CRC cis rs13191362 1.000 rs34066731 chr6:163011047 A/G cg23758597 chr6:163146217 PARK2 -0.55 -6.12 -0.32 2.7e-9 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC trans rs3749237 0.964 rs35210174 chr3:49812606 C/T cg21665057 chr3:196295764 WDR53;FBXO45 0.55 7.78 0.39 9.69e-14 Resting heart rate; CRC cis rs7666738 0.716 rs13136721 chr4:99085602 G/A cg17366294 chr4:99064904 C4orf37 0.35 5.77 0.3 1.82e-8 Colonoscopy-negative controls vs population controls; CRC cis rs644799 0.763 rs2950521 chr11:95536870 G/A cg25478527 chr11:95522999 CEP57;FAM76B 0.51 7.67 0.39 1.95e-13 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC trans rs11098499 0.865 rs1112817 chr4:120297800 T/C cg25214090 chr10:38739885 LOC399744 0.62 9.74 0.47 7.35e-20 Corneal astigmatism; CRC cis rs2290159 0.800 rs5746193 chr3:12658601 C/T cg23032965 chr3:12705835 RAF1 0.47 6.31 0.33 8.78e-10 Cholesterol, total; CRC cis rs17270561 0.609 rs1892248 chr6:25768914 C/T cg16482183 chr6:26056742 HIST1H1C 0.73 9.03 0.45 1.46e-17 Iron status biomarkers; CRC cis rs11212617 1.000 rs680113 chr11:108165406 G/A cg14761454 chr11:108092087 ATM;NPAT 0.42 6.16 0.32 2.08e-9 Response to metformin in type 2 diabetes (glycemic); CRC trans rs10982213 0.830 rs2274163 chr9:117188714 C/T cg05447486 chr1:112162367 RAP1A 0.41 6.23 0.32 1.46e-9 Interleukin-6 levels; CRC cis rs67478160 0.643 rs11626377 chr14:104234357 G/A cg01849466 chr14:104193079 ZFYVE21 -0.5 -9.0 -0.44 1.84e-17 Schizophrenia; CRC cis rs6460942 0.915 rs75732743 chr7:12454095 C/T cg20607287 chr7:12443886 VWDE -0.66 -6.93 -0.36 2.17e-11 Coronary artery disease; CRC cis rs748404 0.660 rs693510 chr15:43714625 C/G cg02155558 chr15:43621948 ADAL;LCMT2 0.53 7.88 0.4 4.67e-14 Lung cancer; CRC cis rs155076 1.000 rs261430 chr13:21865242 C/T cg21970626 chr13:21893289 NA 0.42 5.67 0.3 3.18e-8 White matter hyperintensity burden; CRC cis rs6860806 0.507 rs273915 chr5:131660119 G/C cg11843238 chr5:131593191 PDLIM4 0.43 7.29 0.37 2.38e-12 Breast cancer; CRC cis rs2032447 0.531 rs428469 chr6:25898624 G/A cg26028573 chr6:26043587 HIST1H2BB 0.44 5.7 0.3 2.61e-8 Intelligence (multi-trait analysis); CRC cis rs713477 0.967 rs12431542 chr14:55913078 T/C cg13175173 chr14:55914753 NA -0.53 -10.11 -0.49 4.05e-21 Pediatric bone mineral content (femoral neck); CRC cis rs7552404 1.000 rs4949674 chr1:76213715 C/A cg03433033 chr1:76189801 ACADM 0.81 11.08 0.52 1.81e-24 Blood metabolite levels;Acylcarnitine levels; CRC cis rs3820068 0.626 rs11580170 chr1:15909744 C/T cg13390004 chr1:15929781 NA 0.43 5.76 0.3 1.92e-8 Systolic blood pressure; CRC cis rs7618501 1.000 rs4855867 chr3:49745822 C/T cg24308560 chr3:49941425 MST1R 0.45 7.07 0.36 9.39e-12 Intelligence (multi-trait analysis); CRC cis rs9291683 0.609 rs7678012 chr4:9993772 T/C cg11266682 chr4:10021025 SLC2A9 0.49 10.37 0.5 5.51e-22 Bone mineral density; CRC cis rs6570726 0.935 rs421690 chr6:145834594 A/C cg05347473 chr6:146136440 FBXO30 0.37 6.0 0.31 5.27e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs4713118 0.869 rs9393851 chr6:27699581 A/T cg02683197 chr6:28174875 NA 0.63 8.62 0.43 2.81e-16 Parkinson's disease; CRC cis rs9462027 0.606 rs205260 chr6:34563958 C/G cg07306190 chr6:34760872 UHRF1BP1 -0.35 -6.08 -0.32 3.35e-9 Systemic lupus erythematosus; CRC cis rs9611565 0.592 rs57102627 chr22:41987627 T/C cg03806693 chr22:41940476 POLR3H -0.72 -9.39 -0.46 1.07e-18 Vitiligo; CRC cis rs7666738 0.830 rs28497822 chr4:98906873 C/T cg05340658 chr4:99064831 C4orf37 0.57 8.54 0.43 5.08e-16 Colonoscopy-negative controls vs population controls; CRC cis rs4689388 0.853 rs4293850 chr4:6292020 A/C cg25554036 chr4:6271136 WFS1 0.5 8.07 0.41 1.37e-14 Type 2 diabetes and other traits;Type 2 diabetes; CRC cis rs1008375 1.000 rs6849704 chr4:17652031 G/C cg16339924 chr4:17578868 LAP3 0.58 7.89 0.4 4.45e-14 Parasitemia in Tripanosoma cruzi seropositivity; CRC trans rs7395662 0.591 rs11039776 chr11:48516706 G/A cg21153622 chr11:89784906 NA -0.5 -8.43 -0.42 1.09e-15 HDL cholesterol; CRC cis rs2836974 0.965 rs2836967 chr21:40639102 T/G cg11644478 chr21:40555479 PSMG1 0.81 12.34 0.56 5e-29 Cognitive function; CRC cis rs8062405 1.000 rs7205323 chr16:28865892 C/T cg16576597 chr16:28551801 NUPR1 0.48 6.83 0.35 4.14e-11 Cognitive ability (multi-trait analysis);Cognitive ability; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg16767297 chr16:279223 LUC7L 0.45 6.2 0.32 1.69e-9 Anxiety disorder; CRC cis rs754466 0.651 rs7895188 chr10:79623378 C/G cg26805224 chr10:79626177 DLG5 0.55 8.16 0.41 6.95e-15 Liver enzyme levels (gamma-glutamyl transferase); CRC trans rs1728785 0.901 rs11075687 chr16:68655894 T/C cg04657470 chr2:198365150 HSPE1;HSPD1 0.74 8.94 0.44 2.79e-17 Ulcerative colitis; CRC cis rs72615157 0.697 rs2056726 chr7:99780283 G/A cg07160278 chr7:100027354 MEPCE;ZCWPW1 0.71 8.47 0.42 8.32e-16 Lung function (FEV1/FVC); CRC cis rs9435341 0.896 rs1730851 chr1:107596443 A/G cg09367891 chr1:107599246 PRMT6 -0.65 -9.58 -0.47 2.46e-19 Facial morphology (factor 21, depth of nasal alae); CRC cis rs10504229 1.000 rs57186557 chr8:58177277 A/G cg05313129 chr8:58192883 C8orf71 -0.47 -6.99 -0.36 1.49e-11 Developmental language disorder (linguistic errors); CRC trans rs1814175 0.935 rs28586931 chr11:49693872 G/A cg21153622 chr11:89784906 NA -0.39 -6.1 -0.32 3.02e-9 Height; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg06598631 chr6:88300029 RARS2;ORC3L 0.43 5.99 0.31 5.49e-9 Response to antipsychotic treatment; CRC cis rs854765 0.647 rs854790 chr17:18028318 C/G cg23957660 chr17:17878224 LRRC48 0.37 6.48 0.34 3.28e-10 Total body bone mineral density; CRC cis rs4750440 0.706 rs61837399 chr10:14016047 G/A cg00551146 chr10:14014579 FRMD4A 0.36 5.71 0.3 2.55e-8 Adiponectin levels; CRC cis rs6502050 0.835 rs12950475 chr17:80118924 T/C cg09264619 chr17:80180166 NA -0.35 -5.93 -0.31 7.47e-9 Life satisfaction; CRC cis rs7259376 0.905 rs114170435 chr19:22562522 C/A cg02657401 chr19:22469223 NA -0.32 -7.01 -0.36 1.35e-11 Menopause (age at onset); CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg05164022 chr11:112160734 NA 0.47 5.96 0.31 6.53e-9 Thyroid stimulating hormone; CRC cis rs7647973 0.626 rs6809879 chr3:49834571 A/G cg13072238 chr3:49761600 GMPPB 0.48 5.63 0.3 3.77e-8 Menarche (age at onset); CRC cis rs4713118 0.824 rs9366702 chr6:27734470 T/C cg15786705 chr6:28176104 NA 0.54 7.03 0.36 1.23e-11 Parkinson's disease; CRC cis rs910316 1.000 rs3742778 chr14:75538217 A/C cg08847533 chr14:75593920 NEK9 -0.95 -18.43 -0.71 1.27e-52 Height; CRC cis rs7264396 0.635 rs3827030 chr20:34474947 C/T cg04508476 chr20:34239394 CPNE1;RBM12 0.55 8.78 0.44 8.95e-17 Total cholesterol levels; CRC cis rs4727963 0.846 rs1608829 chr7:122707613 A/G cg03640110 chr7:122635026 TAS2R16 0.33 5.9 0.31 8.95e-9 Adverse response to chemotherapy (neutropenia/leucopenia) (docetaxel); CRC cis rs892961 0.899 rs3650 chr17:75415835 T/C cg05865280 chr17:75406074 SEPT9 0.62 13.91 0.61 6.76e-35 Airflow obstruction; CRC cis rs8060686 0.641 rs2107369 chr16:68116018 A/C cg26727032 chr16:67993705 SLC12A4 -0.62 -8.24 -0.41 4.19e-15 HDL cholesterol;Metabolic syndrome; CRC cis rs13108904 0.875 rs1732099 chr4:1282696 T/C cg20092199 chr4:1342459 KIAA1530 -0.42 -7.71 -0.39 1.54e-13 Obesity-related traits; CRC cis rs172166 0.694 rs1770131 chr6:28086413 C/T cg15786705 chr6:28176104 NA 0.62 8.75 0.43 1.12e-16 Cardiac Troponin-T levels; CRC cis rs870825 0.698 rs66462315 chr4:185623917 C/T cg04058563 chr4:185651563 MLF1IP 0.72 9.38 0.46 1.12e-18 Blood protein levels; CRC cis rs6952808 0.609 rs4721190 chr7:1954732 A/G cg04267008 chr7:1944627 MAD1L1 0.69 10.69 0.51 4.34e-23 Bipolar disorder and schizophrenia; CRC cis rs863345 0.565 rs59188837 chr1:158500636 C/G cg12129480 chr1:158549410 OR10X1 -0.3 -6.27 -0.33 1.12e-9 Pneumococcal bacteremia; CRC cis rs593982 0.920 rs487264 chr11:65481465 A/C cg08755490 chr11:65554678 OVOL1 0.93 10.01 0.48 9.11e-21 Atopic dermatitis; CRC cis rs3733585 0.699 rs7677710 chr4:9969517 T/G cg00071950 chr4:10020882 SLC2A9 -0.54 -9.63 -0.47 1.7e-19 Cleft plate (environmental tobacco smoke interaction); CRC cis rs35306767 0.903 rs11816064 chr10:931176 A/C cg26597838 chr10:835615 NA 0.95 11.66 0.54 1.57e-26 Eosinophil percentage of granulocytes; CRC cis rs9368481 0.761 rs3931464 chr6:26939856 C/A cg12292205 chr6:26970375 C6orf41 0.66 10.9 0.52 7.82e-24 Autism spectrum disorder or schizophrenia; CRC cis rs1568889 0.938 rs12795971 chr11:28355104 G/A cg06544937 chr11:28130018 METT5D1;KIF18A 0.79 10.85 0.51 1.18e-23 Bipolar disorder; CRC cis rs9894429 1.000 rs4074915 chr17:79579230 G/A cg21984481 chr17:79567631 NPLOC4 0.53 9.8 0.48 4.52e-20 Eye color traits; CRC cis rs13191362 0.872 rs36069443 chr6:163248701 T/C cg21926612 chr6:163149169 PACRG;PARK2 0.71 9.14 0.45 6.79e-18 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs875971 0.862 rs6460306 chr7:66060793 T/C cg00343986 chr7:65444356 GUSB -0.45 -6.31 -0.33 9.2e-10 Aortic root size; CRC cis rs2836974 0.627 rs9981301 chr21:40686078 G/C cg22974920 chr21:40686053 BRWD1 -0.42 -5.69 -0.3 2.81e-8 Cognitive function; CRC trans rs1656966 1.000 rs1656966 chr3:186466252 C/T cg21575187 chr5:177558253 RMND5B 0.4 6.03 0.32 4.47e-9 Myopia (pathological); CRC trans rs6951245 1.000 rs1997243 chr7:1083777 A/G cg13565492 chr6:43139072 SRF -0.71 -7.27 -0.37 2.61e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs172166 0.637 rs1071893 chr6:28167635 G/C cg17949981 chr6:28129498 ZNF389 0.4 5.6 0.3 4.43e-8 Cardiac Troponin-T levels; CRC cis rs34233420 1 rs34233420 chr17:38004929 GATTT/G cg17344932 chr17:38183730 MED24;SNORD124 0.36 5.77 0.3 1.79e-8 Lymphocyte counts; CRC cis rs7677751 0.767 rs11133315 chr4:55082158 G/A cg13615338 chr4:55094005 PDGFRA 0.41 5.95 0.31 6.88e-9 Corneal astigmatism; CRC cis rs2075371 1.000 rs1421485 chr7:133985181 C/T cg20476274 chr7:133979776 SLC35B4 0.8 14.55 0.63 2.29e-37 Mean platelet volume; CRC cis rs7772486 0.597 rs6570732 chr6:146245151 G/A cg05347473 chr6:146136440 FBXO30 -0.48 -6.98 -0.36 1.68e-11 Lobe attachment (rater-scored or self-reported); CRC cis rs7587476 0.906 rs16852750 chr2:215646683 A/G cg04004882 chr2:215674386 BARD1 0.62 7.52 0.38 5.09e-13 Neuroblastoma; CRC cis rs3026101 0.671 rs57406064 chr17:5300183 T/C cg25236894 chr17:5323110 RPAIN;NUP88 0.42 6.9 0.36 2.74e-11 Body mass index; CRC cis rs11148252 0.875 rs4884452 chr13:52949784 C/T cg12458913 chr13:53173898 NA -0.51 -8.14 -0.41 8.23e-15 Lewy body disease; CRC cis rs6977940 0.730 rs11770451 chr7:2887990 G/T cg19731401 chr7:2775893 GNA12 0.58 5.65 0.3 3.46e-8 White matter integrity; CRC cis rs7786808 0.705 rs1377373 chr7:158215549 A/C cg09998033 chr7:158218633 PTPRN2 0.62 9.44 0.46 6.96e-19 Obesity-related traits; CRC cis rs780096 0.526 rs4582 chr2:27604279 A/G cg21248554 chr2:27665150 KRTCAP3 -0.31 -7.05 -0.36 1.03e-11 Total body bone mineral density; CRC cis rs2969070 0.831 rs886627 chr7:2498054 C/T cg03277898 chr7:2518824 NA -0.43 -6.21 -0.32 1.57e-9 Diastolic blood pressure; CRC cis rs875971 1.000 rs11974264 chr7:65647582 C/G cg18912574 chr7:65842487 NCRNA00174 -0.37 -6.42 -0.33 4.63e-10 Aortic root size; CRC cis rs6952808 0.792 rs2056480 chr7:1954301 A/G cg22963979 chr7:1858916 MAD1L1 0.5 7.42 0.38 1.01e-12 Bipolar disorder and schizophrenia; CRC cis rs8013055 0.846 rs10147392 chr14:105978537 T/G cg19882132 chr14:106167949 NA -0.42 -6.26 -0.33 1.23e-9 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg00704288 chr1:44172956 ST3GAL3 0.53 7.45 0.38 8.09e-13 Response to antipsychotic treatment; CRC cis rs2976388 0.967 rs2976393 chr8:143763618 C/G cg20041105 chr8:143859282 LYNX1 -0.32 -5.62 -0.3 4.01e-8 Urinary tract infection frequency; CRC cis rs6714710 0.580 rs13032265 chr2:98409565 T/C cg26665480 chr2:98280029 ACTR1B 0.52 7.18 0.37 4.74e-12 Posterior cortical atrophy and Alzheimer's disease; CRC cis rs758324 0.947 rs683749 chr5:131283376 C/T cg25547332 chr5:131281432 NA -0.38 -5.7 -0.3 2.7e-8 Alzheimer's disease in APOE e4- carriers; CRC cis rs4588572 0.643 rs1560195 chr5:77701913 A/G cg11547950 chr5:77652471 NA 0.53 7.43 0.38 9.67e-13 Triglycerides; CRC cis rs6732160 0.613 rs62151837 chr2:73390396 G/T cg01422370 chr2:73384389 NA 0.37 5.68 0.3 3.03e-8 Intelligence (multi-trait analysis); CRC cis rs4319547 0.656 rs4997380 chr12:122838956 A/G cg23029597 chr12:123009494 RSRC2 -0.47 -5.87 -0.31 1.07e-8 Body mass index; CRC cis rs3820068 0.705 rs4646063 chr1:15829813 G/A cg27534772 chr1:16042836 PLEKHM2 0.42 6.69 0.35 9.69e-11 Systolic blood pressure; CRC cis rs9311474 0.659 rs1133415 chr3:52575831 G/A cg18404041 chr3:52824283 ITIH1 -0.34 -7.09 -0.36 8.37e-12 Electroencephalogram traits; CRC cis rs7107174 1.000 rs1942352 chr11:77970563 T/G cg02023728 chr11:77925099 USP35 0.57 9.2 0.45 4.33e-18 Testicular germ cell tumor; CRC cis rs9649213 0.559 rs56997921 chr7:98009224 G/A cg09267113 chr7:98030324 BAIAP2L1 -0.95 -12.85 -0.58 6.88e-31 Prostate cancer (SNP x SNP interaction); CRC cis rs863345 0.625 rs10908655 chr1:158460899 C/T cg12129480 chr1:158549410 OR10X1 -0.29 -6.07 -0.32 3.49e-9 Pneumococcal bacteremia; CRC cis rs4969178 0.895 rs2292640 chr17:76396610 G/A cg05887092 chr17:76393375 PGS1 0.55 10.0 0.48 1.01e-20 HDL cholesterol levels; CRC cis rs7618501 0.633 rs11130228 chr3:50003246 C/T cg24308560 chr3:49941425 MST1R -0.53 -9.0 -0.44 1.8e-17 Intelligence (multi-trait analysis); CRC cis rs1005277 0.579 rs2505198 chr10:38393183 A/C cg17219203 chr10:38645113 HSD17B7P2 -0.41 -5.96 -0.31 6.54e-9 Extrinsic epigenetic age acceleration; CRC cis rs8016982 0.633 rs9944085 chr14:81717620 A/T cg01989461 chr14:81687754 GTF2A1 -0.62 -10.29 -0.49 1.04e-21 Schizophrenia; CRC cis rs1348850 0.567 rs4144276 chr2:178523420 T/C cg02961200 chr2:178257176 LOC100130691;AGPS 0.52 7.19 0.37 4.51e-12 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs2976388 0.590 rs3736011 chr8:143817789 G/A cg10596483 chr8:143751796 JRK -0.46 -6.6 -0.34 1.64e-10 Urinary tract infection frequency; CRC cis rs7493 1.000 rs3735586 chr7:95035582 A/T cg21856205 chr7:94953877 PON1 -0.49 -6.46 -0.34 3.7e-10 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs826838 0.967 rs73096706 chr12:38860563 G/A cg26384229 chr12:38710491 ALG10B 0.77 10.76 0.51 2.48e-23 Heart rate; CRC trans rs3942852 0.910 rs10742829 chr11:48115837 C/T cg03929089 chr4:120376271 NA 0.53 6.36 0.33 6.95e-10 Acute lymphoblastic leukemia (childhood); CRC cis rs9611565 0.659 rs1810461 chr22:41927820 G/A cg03806693 chr22:41940476 POLR3H -1.12 -15.0 -0.64 3.94e-39 Vitiligo; CRC trans rs1814175 0.791 rs10839468 chr11:49986288 A/G cg03929089 chr4:120376271 NA -0.94 -17.92 -0.7 1.32e-50 Height; CRC cis rs4319547 0.626 rs10744210 chr12:122931793 A/G cg23029597 chr12:123009494 RSRC2 -0.55 -6.86 -0.35 3.34e-11 Body mass index; CRC cis rs950169 0.922 rs11630507 chr15:85095725 A/G cg11189052 chr15:85197271 WDR73 0.59 8.69 0.43 1.78e-16 Schizophrenia; CRC cis rs1005277 0.579 rs1780115 chr10:38524773 C/T cg17219203 chr10:38645113 HSD17B7P2 -0.41 -5.92 -0.31 8.11e-9 Extrinsic epigenetic age acceleration; CRC cis rs7666738 0.830 rs1967980 chr4:98966426 C/G cg05340658 chr4:99064831 C4orf37 0.62 9.6 0.47 2.18e-19 Colonoscopy-negative controls vs population controls; CRC cis rs73206853 0.841 rs61663407 chr12:111055128 A/G cg12870014 chr12:110450643 ANKRD13A 0.77 7.23 0.37 3.44e-12 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC cis rs561341 0.830 rs7218801 chr17:30217778 A/G cg23018236 chr17:30244563 NA 0.52 6.72 0.35 7.81e-11 Hip circumference adjusted for BMI; CRC cis rs12044355 0.929 rs6696914 chr1:231853480 G/A cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX 0.45 6.06 0.32 3.72e-9 Alzheimer's disease; CRC cis rs7552404 0.727 rs2172507 chr1:76331320 A/G cg03433033 chr1:76189801 ACADM -0.63 -8.31 -0.42 2.57e-15 Blood metabolite levels;Acylcarnitine levels; CRC cis rs11239544 1 rs11239544 chr10:46007533 C/T cg15590007 chr10:45870220 ALOX5 0.48 6.07 0.32 3.55e-9 Cholesterol, total; CRC cis rs2013441 1.000 rs2013441 chr17:20023099 G/A cg13482628 chr17:19912719 NA 0.41 6.39 0.33 5.67e-10 Obesity-related traits; CRC cis rs6988636 1.000 rs58189203 chr8:124184739 G/T cg27053337 chr8:124217698 FAM83A 0.46 6.83 0.35 4.1e-11 Urinary uromodulin levels; CRC cis rs9916302 0.904 rs8077104 chr17:37530510 A/G cg00129232 chr17:37814104 STARD3 0.53 7.96 0.4 2.76e-14 Glomerular filtration rate (creatinine); CRC cis rs13178541 0.551 rs4315919 chr5:135108794 G/A cg07516956 chr5:134915085 CXCL14 -0.38 -6.63 -0.34 1.39e-10 IgG glycosylation; CRC cis rs10256972 0.681 rs12702016 chr7:1129392 C/T cg04025307 chr7:1156635 C7orf50 0.72 11.75 0.54 7.22e-27 Longevity;Endometriosis; CRC cis rs7208859 0.623 rs56163556 chr17:29101868 G/C cg13385521 chr17:29058706 SUZ12P 0.73 8.4 0.42 1.39e-15 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs9359856 0.564 rs7682 chr6:90352862 G/A cg13799429 chr6:90582589 CASP8AP2 -0.74 -7.94 -0.4 3.18e-14 Bipolar disorder; CRC cis rs1005277 0.540 rs1987431 chr10:37988887 T/C cg25517755 chr10:38738941 LOC399744 -0.42 -6.03 -0.32 4.45e-9 Extrinsic epigenetic age acceleration; CRC cis rs4836694 0.574 rs3780712 chr9:132943082 A/G cg05251000 chr9:132935664 FREQ 0.54 8.06 0.41 1.39e-14 Alzheimer's disease (cognitive decline); CRC cis rs1344694 0.566 rs4672790 chr2:216892446 C/T cg12620499 chr2:216877984 MREG 0.78 12.91 0.58 4.1e-31 Alcohol dependence; CRC cis rs4713118 0.869 rs7776351 chr6:27726731 A/G cg15786705 chr6:28176104 NA -0.52 -7.31 -0.37 2.07e-12 Parkinson's disease; CRC cis rs6860806 0.507 rs635620 chr5:131720263 A/G cg12564285 chr5:131593104 PDLIM4 -0.46 -7.76 -0.39 1.05e-13 Breast cancer; CRC cis rs7208859 0.623 rs6505207 chr17:29076571 T/C cg01831904 chr17:28903510 LRRC37B2 -0.62 -6.39 -0.33 5.8e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs6694672 0.850 rs1412632 chr1:197036868 G/A cg13682187 chr1:196946512 CFHR5 0.48 7.42 0.38 9.89e-13 Asthma; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg16593646 chr5:71616216 PTCD2;MRPS27 0.39 6.54 0.34 2.29e-10 Liver disease severity in Alagille syndrome; CRC cis rs9814567 1.000 rs9809619 chr3:134280948 G/T cg06541857 chr3:134203789 ANAPC13;CEP63 -0.39 -5.95 -0.31 7e-9 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs9894429 0.789 rs6565611 chr17:79598319 T/C cg21984481 chr17:79567631 NPLOC4 -0.57 -10.89 -0.51 8.73e-24 Eye color traits; CRC cis rs6540559 1.000 rs742214 chr1:209960925 T/C cg21951975 chr1:209979733 IRF6 0.47 6.86 0.35 3.34e-11 Cleft lip with or without cleft palate; CRC cis rs9649465 1.000 rs3958047 chr7:123327936 G/C cg03229431 chr7:123269106 ASB15 -0.36 -5.64 -0.3 3.7e-8 Migraine; CRC cis rs7264396 1.000 rs224436 chr20:34154124 T/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.44 -7.15 -0.37 5.83e-12 Total cholesterol levels; CRC cis rs9583531 0.600 rs4773240 chr13:111360585 G/A cg24331049 chr13:111365604 ING1 0.57 7.92 0.4 3.6e-14 Coronary artery disease; CRC cis rs7677751 0.806 rs1800812 chr4:55094629 G/T cg00691999 chr4:55094011 PDGFRA 0.42 5.98 0.31 5.66e-9 Corneal astigmatism; CRC cis rs2932538 0.961 rs6537747 chr1:113179597 C/T cg22162597 chr1:113214053 CAPZA1 -0.61 -8.88 -0.44 4.52e-17 Systolic blood pressure;Diastolic blood pressure;Hypertension;Blood pressure; CRC cis rs897984 0.762 rs7206511 chr16:30950352 G/A cg02466173 chr16:30829666 NA 0.66 9.9 0.48 2.12e-20 Dementia with Lewy bodies; CRC cis rs908922 0.651 rs6671924 chr1:152485830 T/C cg23254163 chr1:152506842 NA 0.46 9.23 0.45 3.42e-18 Hair morphology; CRC trans rs12599106 0.660 rs12919333 chr16:34991336 C/T cg07332563 chr6:291687 DUSP22 -0.59 -8.47 -0.42 8.21e-16 Menopause (age at onset); CRC trans rs7937682 0.961 rs17113227 chr11:111620491 A/G cg18187862 chr3:45730750 SACM1L 0.54 7.79 0.39 8.71e-14 Primary sclerosing cholangitis; CRC cis rs11098499 0.774 rs11098505 chr4:120284627 C/T cg24375607 chr4:120327624 NA 0.48 7.48 0.38 6.72e-13 Corneal astigmatism; CRC trans rs7618501 1.000 rs6802890 chr3:49832261 A/G cg21659725 chr3:3221576 CRBN 0.86 16.3 0.67 3.4e-44 Intelligence (multi-trait analysis); CRC cis rs765787 0.530 rs2668751 chr15:45517293 T/C cg24006582 chr15:45444508 DUOX1 -0.57 -8.6 -0.43 3.35e-16 Uric acid levels; CRC cis rs6582630 0.519 rs1851121 chr12:38389467 T/C cg13010199 chr12:38710504 ALG10B 0.47 6.3 0.33 9.3e-10 Drug-induced liver injury (flucloxacillin); CRC trans rs2727020 0.729 rs6485965 chr11:49166730 C/T cg15704280 chr7:45808275 SEPT13 0.78 12.8 0.58 9.92e-31 Coronary artery disease; CRC cis rs9443645 0.810 rs9361482 chr6:79750385 T/C cg05283184 chr6:79620031 NA -0.59 -9.1 -0.45 8.78e-18 Intelligence (multi-trait analysis); CRC cis rs919433 0.889 rs10931782 chr2:198211579 G/A cg03934865 chr2:198174659 NA -0.39 -6.0 -0.31 5.32e-9 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC cis rs6754311 0.773 rs309176 chr2:136622216 T/C cg25344623 chr2:136566232 LCT 0.33 5.98 0.31 5.97e-9 Mosquito bite size; CRC cis rs910316 0.726 rs175040 chr14:75469555 A/G cg08847533 chr14:75593920 NEK9 -0.85 -14.68 -0.63 7.19e-38 Height; CRC trans rs6749447 0.848 rs10170391 chr2:169009426 A/C cg01878807 chr14:24422368 DHRS4;C14orf167 0.4 6.01 0.31 5.04e-9 Blood pressure; CRC cis rs10256972 0.552 rs2960830 chr7:1200641 T/C cg09177884 chr7:1199841 ZFAND2A -0.54 -8.19 -0.41 5.78e-15 Longevity;Endometriosis; CRC cis rs9467603 1.000 rs9467600 chr6:25792768 C/T cg16898833 chr6:26189333 HIST1H4D 0.77 6.42 0.33 4.89e-10 Intelligence (multi-trait analysis); CRC cis rs932541 1.000 rs6043989 chr20:16455389 C/G cg17003395 chr20:16555519 KIF16B 0.41 5.73 0.3 2.25e-8 Intelligence; CRC trans rs1200821 0.704 rs9888115 chr10:37658351 C/T cg25427524 chr10:38739819 LOC399744 0.42 6.25 0.33 1.25e-9 Hemostatic factors and hematological phenotypes; CRC cis rs60843830 1.000 rs10193373 chr2:281886 T/G cg25945732 chr2:264204 ACP1;SH3YL1 0.71 11.53 0.54 4.43e-26 Spherical equivalent (joint analysis main effects and education interaction); CRC cis rs6502050 0.731 rs11867299 chr17:80088675 C/A cg11859384 chr17:80120422 CCDC57 -0.37 -5.92 -0.31 7.94e-9 Life satisfaction; CRC trans rs7615952 0.741 rs13314845 chr3:125644782 C/T cg07211511 chr3:129823064 LOC729375 -1.07 -17.84 -0.7 2.94e-50 Blood pressure (smoking interaction); CRC cis rs7584330 0.910 rs6713555 chr2:238398182 A/G cg14458575 chr2:238380390 NA -0.73 -12.93 -0.58 3.24e-31 Prostate cancer; CRC cis rs9911578 0.902 rs12948746 chr17:57071892 A/G cg05425664 chr17:57184151 TRIM37 -0.54 -8.45 -0.42 9.73e-16 Intelligence (multi-trait analysis); CRC cis rs17253792 0.822 rs74653073 chr14:56079528 T/C cg01858014 chr14:56050164 KTN1 -0.87 -7.23 -0.37 3.34e-12 Putamen volume; CRC cis rs9291683 0.609 rs36084205 chr4:10028678 A/C cg00071950 chr4:10020882 SLC2A9 0.68 12.89 0.58 4.89e-31 Bone mineral density; CRC cis rs12681287 0.640 rs7460342 chr8:87475137 C/T cg27223183 chr8:87520930 FAM82B -0.52 -7.44 -0.38 8.7e-13 Caudate activity during reward; CRC cis rs939584 0.825 rs7564708 chr2:639055 T/C cg03610516 chr2:642275 NA 0.42 5.64 0.3 3.67e-8 Body mass index; CRC cis rs9894429 0.789 rs9747336 chr17:79584189 C/T cg18240062 chr17:79603768 NPLOC4 0.67 11.91 0.55 2.01e-27 Eye color traits; CRC cis rs1506636 0.924 rs4370458 chr7:123260968 G/A cg03229431 chr7:123269106 ASB15 -0.81 -13.03 -0.58 1.44e-31 Plateletcrit;Platelet count; CRC cis rs847649 1.000 rs12537977 chr7:102539230 C/T cg18108683 chr7:102477205 FBXL13 -0.57 -9.16 -0.45 5.71e-18 Morning vs. evening chronotype; CRC cis rs10504229 0.679 rs6995378 chr8:58113933 C/T cg22535103 chr8:58192502 C8orf71 -0.69 -9.23 -0.45 3.37e-18 Developmental language disorder (linguistic errors); CRC trans rs2018683 0.835 rs7782264 chr7:28978986 A/G cg19402173 chr7:128379420 CALU 0.47 7.09 0.36 8.31e-12 Response to irinotecan and platinum-based chemotherapy in non-small-cell lung cancer; CRC cis rs7618915 0.501 rs62253740 chr3:52684128 A/T cg05573699 chr3:52720067 GNL3;PBRM1 -0.48 -7.14 -0.37 5.85e-12 Bipolar disorder; CRC cis rs1395 0.744 rs9653564 chr2:27472618 G/A cg23587288 chr2:27483067 SLC30A3 -0.4 -6.76 -0.35 6.24e-11 Blood metabolite levels; CRC cis rs11792861 0.851 rs4542004 chr9:111814478 A/G cg14432460 chr9:111696404 IKBKAP;C9orf6 0.42 5.66 0.3 3.25e-8 Menarche (age at onset); CRC cis rs2832191 0.671 rs2409332 chr21:30512779 G/A cg08807101 chr21:30365312 RNF160 -0.52 -7.13 -0.37 6.43e-12 Dental caries; CRC cis rs3785574 0.962 rs35448669 chr17:61938923 G/A cg25654072 chr17:61904446 PSMC5;FTSJ3 0.43 5.97 0.31 6.32e-9 Height; CRC cis rs10911232 0.507 rs9787327 chr1:182978459 A/G ch.1.3577855R chr1:183094577 LAMC1 0.87 15.17 0.64 8.98e-40 Hypertriglyceridemia; CRC cis rs9916302 0.904 rs8070695 chr17:37478062 C/T cg03013999 chr17:37608204 MED1 -0.49 -7.54 -0.38 4.7e-13 Glomerular filtration rate (creatinine); CRC cis rs34779708 0.931 rs11010083 chr10:35351531 C/G cg03585969 chr10:35415529 CREM 0.58 7.75 0.39 1.13e-13 Inflammatory bowel disease;Crohn's disease; CRC cis rs67311347 1.000 rs12638199 chr3:40475285 A/G cg24209194 chr3:40518798 ZNF619 0.42 6.39 0.33 5.83e-10 Renal cell carcinoma; CRC cis rs12431939 1.000 rs67113863 chr14:51653103 G/C cg23942311 chr14:51606299 NA -0.54 -6.15 -0.32 2.26e-9 Cancer; CRC cis rs972578 1.000 rs9611984 chr22:43408562 C/T cg01576275 chr22:43409880 NA -0.46 -7.29 -0.37 2.34e-12 Mean platelet volume; CRC cis rs11190604 1.000 rs2295770 chr10:102239829 G/A cg07080220 chr10:102295463 HIF1AN 0.48 5.81 0.31 1.45e-8 Palmitoleic acid (16:1n-7) levels; CRC trans rs2243480 1.000 rs7792391 chr7:65773429 A/G cg10756647 chr7:56101905 PSPH -0.78 -8.05 -0.41 1.55e-14 Diabetic kidney disease; CRC cis rs2032447 0.531 rs428469 chr6:25898624 G/A cg04800585 chr6:26043546 HIST1H2BB 0.45 5.81 0.3 1.51e-8 Intelligence (multi-trait analysis); CRC trans rs800082 0.516 rs9813164 chr3:144227590 A/G cg24215973 chr2:240111563 HDAC4 0.48 6.65 0.34 1.26e-10 Smoking behavior; CRC cis rs2404602 0.647 rs11855296 chr15:77092962 C/T cg23625390 chr15:77176239 SCAPER -0.85 -12.98 -0.58 2.23e-31 Blood metabolite levels; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg12841375 chr6:52929709 FBXO9 0.45 6.25 0.33 1.29e-9 Response to antipsychotic treatment; CRC cis rs875971 1.000 rs1144895 chr7:65541307 C/G cg12463550 chr7:65579703 CRCP -0.49 -6.98 -0.36 1.6e-11 Aortic root size; CRC cis rs2153535 0.580 rs9406164 chr6:8470048 C/T cg07606381 chr6:8435919 SLC35B3 0.68 10.9 0.51 8.26e-24 Motion sickness; CRC trans rs9650657 0.547 rs11250099 chr8:10818657 C/T cg06636001 chr8:8085503 FLJ10661 0.52 7.33 0.37 1.8e-12 Neuroticism; CRC cis rs17401966 1.000 rs3748578 chr1:10420918 A/G cg19773385 chr1:10388646 KIF1B 0.61 8.81 0.44 7.5e-17 Hepatocellular carcinoma; CRC cis rs875971 0.964 rs2277911 chr7:65958625 T/G cg11764359 chr7:65958608 NA 0.63 10.13 0.49 3.71e-21 Aortic root size; CRC cis rs17001868 0.527 rs73167009 chr22:40734249 T/C cg07138101 chr22:40742427 ADSL 0.6 7.82 0.4 7.06e-14 Mammographic density (dense area); CRC trans rs11098499 0.754 rs4107728 chr4:120253910 G/A cg25214090 chr10:38739885 LOC399744 0.53 8.46 0.42 8.61e-16 Corneal astigmatism; CRC cis rs11123170 0.640 rs1015754 chr2:113967990 T/C cg21610815 chr2:113994035 PAX8;LOC654433;LOC440839 -0.49 -6.46 -0.34 3.74e-10 Renal function-related traits (BUN); CRC cis rs4555082 0.874 rs1008628 chr14:105722726 T/C cg10792982 chr14:105748885 BRF1 0.37 6.31 0.33 9e-10 Mean platelet volume;Platelet distribution width; CRC cis rs1355223 0.552 rs2421743 chr11:34882840 C/T cg11058730 chr11:34937778 PDHX;APIP 0.73 11.95 0.55 1.35e-27 Systemic lupus erythematosus and Systemic sclerosis; CRC cis rs3858526 0.834 rs10839169 chr11:6003190 C/G cg05234568 chr11:5960015 NA -0.47 -5.96 -0.31 6.48e-9 DNA methylation (variation); CRC cis rs873946 0.586 rs3829130 chr10:134563122 C/T cg18305652 chr10:134549665 INPP5A 0.49 6.24 0.33 1.38e-9 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CRC cis rs6988985 0.678 rs10087214 chr8:143999726 G/A cg10324643 chr8:143916377 GML 0.39 6.54 0.34 2.34e-10 Plasma androstenedione levels in resected early stage-receptor positive breast cancer; CRC cis rs741668 1.000 rs2806923 chr13:46518570 T/C cg06018095 chr13:46550134 ZC3H13 -0.4 -5.81 -0.31 1.46e-8 Cerebrospinal fluid clusterin levels; CRC cis rs12630931 0.798 rs9816495 chr3:31989374 C/G cg21375017 chr3:31988082 OSBPL10 -0.42 -6.09 -0.32 3.21e-9 Periodontal disease-related phenotypes; CRC cis rs10504229 0.683 rs55881798 chr8:58106406 T/C cg02725872 chr8:58115012 NA -0.65 -11.14 -0.52 1.14e-24 Developmental language disorder (linguistic errors); CRC cis rs57221529 0.766 rs72706606 chr5:558609 T/C cg17948913 chr5:572064 NA 0.55 6.33 0.33 7.93e-10 Lung disease severity in cystic fibrosis; CRC cis rs2625529 0.730 rs982752 chr15:72145937 C/T cg16672083 chr15:72433130 SENP8 -0.47 -7.14 -0.37 6.2e-12 Red blood cell count; CRC cis rs7119 0.717 rs12916973 chr15:77808099 C/T cg27398640 chr15:77910606 LINGO1 0.44 7.39 0.38 1.19e-12 Type 2 diabetes; CRC cis rs9487051 0.836 rs9487036 chr6:109607449 C/T cg12927641 chr6:109611667 NA -0.39 -6.99 -0.36 1.54e-11 Reticulocyte fraction of red cells; CRC cis rs1105228 0.921 rs479273 chr6:165715006 A/G cg20535254 chr6:165714960 C6orf118 0.29 5.99 0.31 5.56e-9 Number of pregnancies;Number of children; CRC cis rs4731207 0.596 rs12111660 chr7:124584795 A/C cg23710748 chr7:124431027 NA -0.38 -6.08 -0.32 3.35e-9 Cutaneous malignant melanoma; CRC cis rs593982 0.688 rs3897552 chr11:65560880 C/T cg08755490 chr11:65554678 OVOL1 -1.12 -11.64 -0.54 1.86e-26 Atopic dermatitis; CRC cis rs422249 0.512 rs174562 chr11:61585144 A/G cg00603274 chr11:61596626 FADS2 -0.44 -6.31 -0.33 9.15e-10 Trans fatty acid levels; CRC cis rs12701220 0.744 rs2030958 chr7:1076010 G/T cg06145435 chr7:1022769 CYP2W1 0.4 5.67 0.3 3.13e-8 Bronchopulmonary dysplasia; CRC cis rs7552404 1.000 rs7552404 chr1:76135946 A/G cg03433033 chr1:76189801 ACADM 0.82 11.39 0.53 1.41e-25 Blood metabolite levels;Acylcarnitine levels; CRC cis rs1799949 1.000 rs3092994 chr17:41215825 C/T cg25072359 chr17:41440525 NA 0.48 7.23 0.37 3.49e-12 Menopause (age at onset); CRC cis rs7589728 1.000 rs11893832 chr2:88507537 G/C cg04511125 chr2:88470314 THNSL2 0.66 6.47 0.34 3.48e-10 Plasma clusterin levels; CRC cis rs2576037 0.583 rs892586 chr18:44560429 C/A cg23996704 chr18:44553084 KATNAL2 0.4 7.81 0.4 7.66e-14 Personality dimensions; CRC cis rs10504229 0.683 rs11784908 chr8:58131472 T/C cg21724239 chr8:58056113 NA 0.49 6.81 0.35 4.75e-11 Developmental language disorder (linguistic errors); CRC cis rs6952808 0.792 rs12536261 chr7:1953571 G/A cg21782813 chr7:2030301 MAD1L1 0.45 7.59 0.39 3.29e-13 Bipolar disorder and schizophrenia; CRC cis rs3741151 0.773 rs7110369 chr11:73160946 C/A cg17517138 chr11:73019481 ARHGEF17 1.04 8.44 0.42 1.01e-15 GIP levels in response to oral glucose tolerance test (120 minutes); CRC cis rs9534288 0.830 rs1126363 chr13:46633459 C/T cg15192986 chr13:46630673 CPB2 -0.78 -10.96 -0.52 5.02e-24 Blood protein levels; CRC cis rs7845219 0.544 rs10956932 chr8:95948202 C/T cg16049864 chr8:95962084 TP53INP1 0.45 7.49 0.38 6.26e-13 Type 2 diabetes; CRC cis rs11098499 0.754 rs12513083 chr4:120249612 A/T cg24375607 chr4:120327624 NA 0.47 7.6 0.39 3.06e-13 Corneal astigmatism; CRC cis rs3857067 0.806 rs10008044 chr4:95092850 A/G cg11021082 chr4:95130006 SMARCAD1 -0.49 -7.65 -0.39 2.22e-13 QT interval; CRC cis rs4731207 0.698 rs4728011 chr7:124481712 C/T cg23710748 chr7:124431027 NA 0.38 6.08 0.32 3.42e-9 Cutaneous malignant melanoma; CRC cis rs67311347 1.000 rs4973998 chr3:40460352 C/T cg09455208 chr3:40491958 NA 0.51 10.13 0.49 3.65e-21 Renal cell carcinoma; CRC cis rs2019137 0.936 rs3828189 chr2:113954496 T/A cg21482265 chr2:113992762 PAX8;LOC440839;LOC654433 -0.46 -6.57 -0.34 1.94e-10 Lymphocyte counts; CRC cis rs9902453 1.000 rs4350617 chr17:28423088 G/A cg26525008 chr17:28256777 EFCAB5;SSH2 0.59 8.79 0.44 8.21e-17 Coffee consumption (cups per day); CRC cis rs4819052 0.851 rs13047598 chr21:46660777 G/T cg11663144 chr21:46675770 NA -0.83 -14.12 -0.61 9.88e-36 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs4713675 0.565 rs1555965 chr6:33677400 A/G cg14003231 chr6:33640908 ITPR3 0.49 7.85 0.4 5.97e-14 Plateletcrit; CRC cis rs12472274 0.646 rs34465035 chr2:239114093 C/A cg17459225 chr2:239074497 NA 0.68 7.94 0.4 3.27e-14 Phospholipid levels (plasma); CRC cis rs904251 0.600 rs2270687 chr6:37418263 A/G cg25019722 chr6:37503610 NA -0.38 -6.69 -0.35 9.34e-11 Cognitive performance; CRC cis rs898097 0.841 rs12453162 chr17:80859971 C/T cg19046167 chr17:80928561 B3GNTL1 -0.44 -6.73 -0.35 7.72e-11 Breast cancer; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg06080793 chr6:1625457 GMDS 0.22 6.16 0.32 2.13e-9 Liver disease severity in Alagille syndrome; CRC cis rs6088580 0.609 rs945674 chr20:32964247 G/C cg24642439 chr20:33292090 TP53INP2 -0.37 -6.31 -0.33 8.76e-10 Glomerular filtration rate (creatinine); CRC cis rs4713118 0.513 rs149958 chr6:28013617 A/C cg25164649 chr6:28176230 NA 0.59 8.37 0.42 1.63e-15 Parkinson's disease; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg07688604 chr12:133065928 FBRSL1 0.45 6.24 0.33 1.38e-9 Anxiety disorder; CRC cis rs9381040 0.610 rs6919961 chr6:41020361 T/A cg09580153 chr6:41068724 NFYA;LOC221442 -0.42 -6.19 -0.32 1.77e-9 Alzheimer's disease (late onset); CRC cis rs11098499 0.908 rs9995234 chr4:120321827 A/G cg09307838 chr4:120376055 NA 0.71 10.85 0.51 1.23e-23 Corneal astigmatism; CRC trans rs11098499 0.909 rs28884220 chr4:120307211 A/G cg25214090 chr10:38739885 LOC399744 0.62 9.7 0.47 1.01e-19 Corneal astigmatism; CRC cis rs66573146 1.000 rs67405518 chr4:6965930 C/T cg00086871 chr4:6988644 TBC1D14 1.01 7.58 0.39 3.49e-13 Granulocyte percentage of myeloid white cells; CRC cis rs4132509 0.744 rs12124113 chr1:243904366 A/G cg21452805 chr1:244014465 NA 0.59 7.73 0.39 1.3e-13 RR interval (heart rate); CRC cis rs559928 0.606 rs55942618 chr11:63936005 C/T cg19465662 chr11:63993652 NUDT22;TRPT1 0.7 6.67 0.34 1.11e-10 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; CRC cis rs2153535 0.580 rs9378556 chr6:8514695 A/G cg21535247 chr6:8435926 SLC35B3 0.49 7.43 0.38 9.25e-13 Motion sickness; CRC trans rs6951245 1.000 rs74369356 chr7:1071711 T/C cg13565492 chr6:43139072 SRF -0.71 -7.31 -0.37 2.04e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs1129187 0.755 rs28868299 chr6:42921221 T/G cg02353165 chr6:42928485 GNMT 0.71 11.6 0.54 2.58e-26 Alzheimer's disease in APOE e4+ carriers; CRC trans rs561341 0.714 rs474455 chr17:30312465 A/T cg20587970 chr11:113659929 NA -1.18 -17.36 -0.69 2.24e-48 Hip circumference adjusted for BMI; CRC cis rs4555082 0.750 rs2816650 chr14:105708343 C/T cg18132624 chr14:105716052 BTBD6;BRF1 -0.49 -8.0 -0.4 2.15e-14 Mean platelet volume;Platelet distribution width; CRC cis rs4563143 0.675 rs56322221 chr19:29270349 A/T cg12756686 chr19:29218302 NA 0.61 9.08 0.45 1.01e-17 Methadone dose in opioid dependence; CRC cis rs6089584 0.606 rs6089599 chr20:60576992 A/G cg06108461 chr20:60628389 TAF4 0.6 10.33 0.49 7.46e-22 Body mass index; CRC cis rs7726839 0.540 rs12520279 chr5:657291 T/C cg14541582 chr5:601475 NA -0.33 -6.59 -0.34 1.73e-10 Obesity-related traits; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg11907102 chr2:201936469 NDUFB3;FAM126B 0.44 6.17 0.32 2.03e-9 Response to antipsychotic treatment; CRC trans rs6550704 0.687 rs9865314 chr3:22634337 A/G cg20470467 chr16:30886130 NA -0.41 -5.98 -0.31 5.71e-9 Daytime sleep phenotypes; CRC cis rs875971 0.545 rs1267814 chr7:66044409 G/A cg03233332 chr7:66118400 NA 0.44 6.14 0.32 2.44e-9 Aortic root size; CRC cis rs282587 0.569 rs408826 chr13:113415268 G/A cg04656015 chr13:113407548 ATP11A 0.63 7.72 0.39 1.37e-13 Glycated hemoglobin levels; CRC cis rs11122272 0.735 rs2808583 chr1:231512587 G/C cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.54 -7.98 -0.4 2.38e-14 Hemoglobin concentration; CRC cis rs10744422 1.000 rs7138398 chr12:123341833 G/C cg25930673 chr12:123319894 HIP1R -0.6 -6.36 -0.33 6.71e-10 Schizophrenia; CRC cis rs2204008 0.837 rs11611861 chr12:38357459 A/G cg26384229 chr12:38710491 ALG10B 0.69 9.77 0.47 5.95e-20 Bladder cancer; CRC cis rs3796619 1.000 rs11939380 chr4:1086871 C/T cg27284194 chr4:1044797 NA -0.41 -6.38 -0.33 6.17e-10 Recombination rate (males); CRC trans rs1814175 0.645 rs7103554 chr11:50027612 G/A cg15704280 chr7:45808275 SEPT13 -0.93 -17.0 -0.68 5.6e-47 Height; CRC cis rs4285028 0.699 rs73855465 chr3:121574219 C/T cg11130432 chr3:121712080 ILDR1 -0.47 -5.86 -0.31 1.12e-8 Multiple sclerosis; CRC cis rs1801251 0.964 rs13007783 chr2:233566679 G/A cg25237894 chr2:233734115 C2orf82 0.49 8.03 0.4 1.73e-14 Coronary artery disease; CRC cis rs4466137 0.903 rs3734092 chr5:83016743 C/T cg15083037 chr5:83017644 HAPLN1 -0.53 -6.88 -0.35 3.06e-11 Prostate cancer; CRC cis rs7224685 0.501 rs781842 chr17:3958955 C/T cg21851534 chr17:3907994 ZZEF1 0.38 6.7 0.35 9.06e-11 Type 2 diabetes; CRC cis rs9325144 0.600 rs7965877 chr12:38743697 G/T cg26384229 chr12:38710491 ALG10B 0.51 7.7 0.39 1.59e-13 Morning vs. evening chronotype; CRC trans rs11026407 0.967 rs7127246 chr11:22060228 C/G cg21208545 chr3:11851506 C3orf31 -0.53 -6.02 -0.31 4.53e-9 Plasma thyroid-stimulating hormone levels; CRC cis rs7527798 0.637 rs7515149 chr1:207838352 T/G cg09232269 chr1:207846808 CR1L -0.53 -8.62 -0.43 2.78e-16 Erythrocyte sedimentation rate; CRC trans rs2303319 0.504 rs1023835 chr2:162593973 A/G cg23919916 chr10:103825097 HPS6 -0.69 -6.01 -0.31 4.8e-9 Cognitive function; CRC cis rs2014572 0.933 rs8107516 chr19:57758445 A/G cg12963866 chr19:57752005 ZNF805 -0.41 -6.01 -0.31 4.96e-9 Hyperactive-impulsive symptoms; CRC cis rs3087591 0.664 rs2525565 chr17:29666588 T/C cg24425628 chr17:29625626 OMG;NF1 0.68 12.48 0.57 1.58e-29 Hip circumference; CRC cis rs7811142 0.943 rs11769886 chr7:99998607 G/A cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.57 6.76 0.35 6.43e-11 Platelet count; CRC cis rs55882075 0.967 rs59666900 chr5:179147641 C/T cg14593053 chr5:179126677 CANX 0.48 7.55 0.38 4.35e-13 Monocyte percentage of white cells; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg09033691 chr11:10829409 EIF4G2 0.44 6.64 0.34 1.32e-10 Intelligence (multi-trait analysis); CRC cis rs2243480 1.000 rs1392104 chr7:65759107 G/A cg12463550 chr7:65579703 CRCP -0.68 -6.07 -0.32 3.43e-9 Diabetic kidney disease; CRC cis rs79387448 0.745 rs17027421 chr2:103159882 A/G cg09003973 chr2:102972529 NA 0.73 8.01 0.4 1.97e-14 Gut microbiota (bacterial taxa); CRC cis rs763121 0.853 rs5750672 chr22:39104168 C/T cg06544989 chr22:39130855 UNC84B -0.44 -6.75 -0.35 6.76e-11 Menopause (age at onset); CRC cis rs7829975 0.659 rs4382480 chr8:8721473 C/T cg11608241 chr8:8085544 FLJ10661 0.39 5.74 0.3 2.17e-8 Mood instability; CRC cis rs7927771 0.965 rs12364432 chr11:47902883 G/A cg18512352 chr11:47633146 NA -0.48 -9.2 -0.45 4.16e-18 Subjective well-being; CRC cis rs2046867 0.818 rs62251647 chr3:72805789 G/A cg25664220 chr3:72788482 NA -0.46 -6.39 -0.33 5.6e-10 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; CRC cis rs10911232 0.507 rs3934578 chr1:183027216 T/C ch.1.3577855R chr1:183094577 LAMC1 0.83 14.62 0.63 1.24e-37 Hypertriglyceridemia; CRC cis rs9733 0.596 rs12089731 chr1:150647798 T/C cg17724175 chr1:150552817 MCL1 0.58 9.4 0.46 9.25e-19 Tonsillectomy; CRC cis rs7666738 0.753 rs13137152 chr4:98938044 A/T cg17366294 chr4:99064904 C4orf37 0.42 7.13 0.37 6.33e-12 Colonoscopy-negative controls vs population controls; CRC cis rs1552244 0.572 rs59074548 chr3:10164347 G/C cg00166722 chr3:10149974 C3orf24 0.65 7.7 0.39 1.56e-13 Alzheimer's disease; CRC cis rs453301 0.571 rs2929456 chr8:9083416 G/A cg06636001 chr8:8085503 FLJ10661 -0.58 -9.33 -0.46 1.65e-18 Joint mobility (Beighton score); CRC cis rs4474465 0.790 rs10899554 chr11:78265667 T/G cg02023728 chr11:77925099 USP35 -0.36 -6.06 -0.32 3.72e-9 Alzheimer's disease (survival time); CRC cis rs3126085 0.935 rs11204941 chr1:152203343 A/G cg09127314 chr1:152161683 NA 0.49 6.28 0.33 1.07e-9 Atopic dermatitis; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg04244535 chr14:23236155 OXA1L 0.48 7.02 0.36 1.26e-11 Intelligence (multi-trait analysis); CRC trans rs3733585 0.638 rs6414766 chr4:9956474 G/A cg26043149 chr18:55253948 FECH -0.5 -7.67 -0.39 1.92e-13 Cleft plate (environmental tobacco smoke interaction); CRC trans rs61931739 0.500 rs7310576 chr12:34474735 T/C cg13010199 chr12:38710504 ALG10B 0.44 6.08 0.32 3.39e-9 Morning vs. evening chronotype; CRC trans rs4942242 1.000 rs9533566 chr13:44224691 T/C cg26741380 chr15:41871084 TYRO3 -0.41 -6.22 -0.32 1.49e-9 Response to tocilizumab in rheumatoid arthritis; CRC cis rs11608355 0.597 rs7300290 chr12:109832545 T/G cg19025524 chr12:109796872 NA -0.57 -9.38 -0.46 1.09e-18 Neuroticism; CRC cis rs4474465 0.646 rs10793337 chr11:78285875 A/T cg02023728 chr11:77925099 USP35 -0.34 -5.77 -0.3 1.84e-8 Alzheimer's disease (survival time); CRC cis rs7772486 0.790 rs6570723 chr6:146151230 A/T cg23711669 chr6:146136114 FBXO30 0.67 11.47 0.53 7.77e-26 Lobe attachment (rater-scored or self-reported); CRC cis rs754466 0.561 rs67332822 chr10:79706118 G/A cg17075019 chr10:79541650 NA -0.6 -6.8 -0.35 4.82e-11 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs7927771 0.832 rs7924485 chr11:47419129 A/G cg18512352 chr11:47633146 NA 0.4 7.69 0.39 1.74e-13 Subjective well-being; CRC cis rs6912958 0.500 rs4706287 chr6:87806496 A/G cg04972856 chr6:88032051 C6orf162;GJB7 -0.32 -5.7 -0.3 2.71e-8 Monocyte percentage of white cells; CRC cis rs2346177 0.967 rs4953374 chr2:46654401 T/C cg26688816 chr2:46740690 ATP6V1E2 -0.54 -8.67 -0.43 1.93e-16 HDL cholesterol; CRC cis rs4566357 0.615 rs12328876 chr2:227918899 G/T cg11843606 chr2:227700838 RHBDD1 -0.45 -6.85 -0.35 3.65e-11 Coronary artery disease; CRC cis rs10504229 0.728 rs17804720 chr8:58154565 T/C cg22535103 chr8:58192502 C8orf71 -0.68 -8.37 -0.42 1.72e-15 Developmental language disorder (linguistic errors); CRC cis rs1552244 0.882 rs13084194 chr3:10031492 T/A cg00166722 chr3:10149974 C3orf24 0.62 7.61 0.39 2.98e-13 Alzheimer's disease; CRC cis rs10504229 1.000 rs61212428 chr8:58173963 G/A cg22535103 chr8:58192502 C8orf71 -0.82 -12.27 -0.56 9.63e-29 Developmental language disorder (linguistic errors); CRC cis rs4665809 1.000 rs750450 chr2:26324631 A/G cg26119090 chr2:26468346 HADHA;HADHB -0.64 -7.99 -0.4 2.25e-14 Gut microbiome composition (summer); CRC cis rs875971 0.545 rs6460298 chr7:65907770 T/C cg05627663 chr7:65219948 SNORA22;CCT6P1 0.58 7.47 0.38 7.06e-13 Aortic root size; CRC cis rs10504229 0.679 rs7813252 chr8:58136389 C/G cg21724239 chr8:58056113 NA 0.48 6.75 0.35 6.74e-11 Developmental language disorder (linguistic errors); CRC cis rs6089584 0.850 rs6142939 chr20:60627729 A/G cg23463467 chr20:60627584 TAF4 0.36 6.39 0.33 5.67e-10 Body mass index; CRC cis rs921968 0.643 rs552882 chr2:219401726 G/A cg02176678 chr2:219576539 TTLL4 0.48 7.98 0.4 2.45e-14 Mean corpuscular hemoglobin concentration; CRC cis rs447 0.887 rs6467988 chr7:83756500 C/T cg22846510 chr7:83753280 SEMA3A -0.61 -7.79 -0.39 8.85e-14 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs9534288 0.763 rs7989605 chr13:46534036 G/A cg15192986 chr13:46630673 CPB2 -0.68 -9.96 -0.48 1.31e-20 Blood protein levels; CRC cis rs2276314 0.947 rs4799831 chr18:33554775 A/G cg19628046 chr18:33552617 C18orf21 0.46 6.14 0.32 2.35e-9 Endometriosis;Drug-induced torsades de pointes; CRC cis rs6495122 0.644 rs62029217 chr15:75261899 C/T cg21523564 chr15:75251491 NA 0.42 6.12 0.32 2.65e-9 Caffeine consumption;Diastolic blood pressure;Coffee consumption; CRC cis rs4654899 0.931 rs1152998 chr1:21124290 C/T cg02927042 chr1:21476669 EIF4G3 -0.43 -6.87 -0.35 3.24e-11 Superior frontal gyrus grey matter volume; CRC cis rs172166 0.694 rs9295760 chr6:28147385 G/A cg03623178 chr6:28175578 NA 0.81 11.99 0.55 1.02e-27 Cardiac Troponin-T levels; CRC trans rs11148252 0.811 rs9536030 chr13:52938291 G/A cg18335740 chr13:41363409 SLC25A15 -0.5 -7.84 -0.4 6.12e-14 Lewy body disease; CRC cis rs10927875 0.722 rs1763605 chr1:16338925 T/G cg10494257 chr1:16342123 HSPB7 0.45 6.0 0.31 5.3e-9 Dilated cardiomyopathy; CRC cis rs1552244 0.872 rs6803517 chr3:10065426 C/T cg18598329 chr3:10140678 FANCD2;C3orf24 -0.88 -12.22 -0.56 1.48e-28 Alzheimer's disease; CRC cis rs11098499 0.754 rs12507565 chr4:120251121 G/A cg24375607 chr4:120327624 NA 0.47 7.6 0.39 3.06e-13 Corneal astigmatism; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg09740319 chr1:231004641 C1orf198 0.48 7.01 0.36 1.38e-11 Intelligence (multi-trait analysis); CRC cis rs968567 0.705 rs174573 chr11:61600327 G/A cg00603274 chr11:61596626 FADS2 -0.56 -7.53 -0.38 4.9e-13 Blood metabolite levels;Rheumatoid arthritis;Vitiligo;Glycerophospholipid levels; CRC cis rs72781680 0.851 rs12612830 chr2:24134599 C/T cg08917208 chr2:24149416 ATAD2B 0.91 9.24 0.45 3.06e-18 Lymphocyte counts; CRC cis rs2180341 0.618 rs12210968 chr6:127596985 A/G cg27446573 chr6:127587934 RNF146 0.62 9.35 0.46 1.43e-18 Breast cancer; CRC cis rs12824058 0.831 rs12322456 chr12:130813594 A/G cg26677194 chr12:130822605 PIWIL1 0.45 7.22 0.37 3.72e-12 Menopause (age at onset); CRC cis rs208520 0.690 rs851464 chr6:66839802 C/T cg07460842 chr6:66804631 NA -1.1 -15.04 -0.64 2.83e-39 Exhaled nitric oxide output; CRC trans rs61931739 0.517 rs12815556 chr12:34319670 G/A cg26384229 chr12:38710491 ALG10B 0.56 7.12 0.37 6.76e-12 Morning vs. evening chronotype; CRC cis rs10992471 0.603 rs12336884 chr9:95234183 A/C cg14631576 chr9:95140430 CENPP -0.41 -7.34 -0.37 1.73e-12 Visceral adipose tissue/subcutaneous adipose tissue ratio; CRC cis rs7085104 0.572 rs284857 chr10:104574063 C/T cg23093090 chr10:104574429 C10orf26 0.4 6.74 0.35 7.25e-11 Immature fraction of reticulocytes;Schizophrenia; CRC cis rs9814567 0.806 rs9824185 chr3:134324024 G/C cg06541857 chr3:134203789 ANAPC13;CEP63 -0.37 -5.71 -0.3 2.47e-8 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs9325144 0.624 rs10783333 chr12:39118931 A/T cg26384229 chr12:38710491 ALG10B 0.47 6.69 0.35 9.37e-11 Morning vs. evening chronotype; CRC cis rs9467711 0.591 rs13195692 chr6:26044373 C/T cg08501292 chr6:25962987 TRIM38 0.84 7.97 0.4 2.63e-14 Autism spectrum disorder or schizophrenia; CRC cis rs1997103 0.822 rs10273426 chr7:55417857 G/A cg17469321 chr7:55412551 NA 0.71 10.69 0.51 4.22e-23 QRS interval (sulfonylurea treatment interaction); CRC cis rs3790455 0.610 rs1171548 chr1:156471998 G/T cg14087168 chr1:156450669 MEF2D -0.35 -5.89 -0.31 9.79e-9 Migraine; CRC cis rs4888262 0.545 rs58136167 chr16:74700628 G/A cg01733217 chr16:74700730 RFWD3 0.82 13.1 0.59 7.63e-32 Testicular germ cell tumor; CRC cis rs11992186 0.570 rs17628941 chr8:8587534 G/C cg06636001 chr8:8085503 FLJ10661 -0.48 -6.87 -0.35 3.28e-11 Neuroticism; CRC cis rs4711350 0.862 rs487835 chr6:33710933 G/A cg07979401 chr6:33739406 LEMD2 0.48 6.0 0.31 5.1e-9 Schizophrenia; CRC cis rs79976124 0.797 rs78317899 chr6:66652896 C/A cg07460842 chr6:66804631 NA 0.75 9.36 0.46 1.31e-18 Type 2 diabetes; CRC cis rs2658782 0.901 rs7116173 chr11:93222311 C/T cg15737290 chr11:93063684 CCDC67 -0.47 -6.58 -0.34 1.88e-10 Pulmonary function decline; CRC cis rs12760731 0.565 rs2095133 chr1:178198612 C/G cg00404053 chr1:178313656 RASAL2 1.05 10.9 0.52 7.84e-24 Obesity-related traits; CRC cis rs7824557 0.564 rs2572400 chr8:11234367 T/G cg20542592 chr8:11973495 FAM66D 0.32 5.69 0.3 2.76e-8 Retinal vascular caliber; CRC cis rs3806843 0.735 rs778595 chr5:140036681 G/A cg16607685 chr5:140181889 PCDHA2;PCDHA1;PCDHA3 0.25 5.76 0.3 1.92e-8 Depressive symptoms (multi-trait analysis); CRC cis rs12586317 0.534 rs28384418 chr14:35452126 C/A cg05294307 chr14:35346193 BAZ1A -0.71 -9.11 -0.45 7.97e-18 Psoriasis; CRC cis rs8141529 0.748 rs9620841 chr22:29290981 C/T cg02153584 chr22:29168773 CCDC117 0.48 6.9 0.36 2.75e-11 Lymphocyte counts; CRC cis rs2487048 0.725 rs2246293 chr9:107690838 C/G cg14470647 chr9:107690075 ABCA1 0.38 5.7 0.3 2.62e-8 Intraocular pressure; CRC cis rs889312 0.500 rs11960484 chr5:56109154 C/T cg20203395 chr5:56204925 C5orf35 0.4 5.65 0.3 3.49e-8 Breast cancer;Breast cancer (early onset); CRC cis rs9303280 0.840 rs12939457 chr17:38032188 T/C cg00129232 chr17:37814104 STARD3 -0.45 -7.16 -0.37 5.33e-12 Self-reported allergy; CRC cis rs3858526 0.959 rs61876224 chr11:5952859 G/A cg02574844 chr11:5959923 NA -0.45 -6.35 -0.33 7.09e-10 DNA methylation (variation); CRC cis rs1799949 0.965 rs11650132 chr17:41326087 T/G cg05368731 chr17:41323189 NBR1 0.65 9.5 0.46 4.35e-19 Menopause (age at onset); CRC cis rs6951245 0.935 rs79143504 chr7:1110212 A/G cg24642844 chr7:1081250 C7orf50 -0.78 -9.13 -0.45 7.07e-18 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs5753618 0.561 rs9609264 chr22:31746719 C/G cg22777020 chr22:31556080 RNF185 0.54 6.3 0.33 9.52e-10 Colorectal cancer; CRC cis rs806215 1.000 rs712700 chr7:127250907 T/C cg25922125 chr7:127225783 GCC1 0.58 6.37 0.33 6.52e-10 Type 2 diabetes; CRC cis rs7927771 1.000 rs1317149 chr11:47486885 C/T cg20307385 chr11:47447363 PSMC3 -0.59 -8.23 -0.41 4.41e-15 Subjective well-being; CRC cis rs9388451 0.839 rs4897155 chr6:126095144 C/A cg10911889 chr6:126070802 HEY2 0.39 5.94 0.31 7.15e-9 Brugada syndrome; CRC cis rs875971 0.545 rs801212 chr7:66015630 C/G cg03233332 chr7:66118400 NA 0.43 5.98 0.31 5.79e-9 Aortic root size; CRC cis rs7613875 0.600 rs2247510 chr3:50126215 A/C cg24308560 chr3:49941425 MST1R -0.41 -6.3 -0.33 9.49e-10 Body mass index; CRC cis rs11098499 0.657 rs4463052 chr4:120313258 T/C cg09307838 chr4:120376055 NA 0.71 10.93 0.52 6.41e-24 Corneal astigmatism; CRC cis rs12760731 0.582 rs9803679 chr1:178410425 T/C cg00404053 chr1:178313656 RASAL2 0.75 9.35 0.46 1.4e-18 Obesity-related traits; CRC cis rs3008870 1.000 rs2985811 chr1:67377722 G/T cg08660285 chr1:67390436 MIER1;WDR78 1.05 16.33 0.67 2.62e-44 Lymphocyte percentage of white cells; CRC cis rs1552244 1.000 rs13319597 chr3:10126312 A/C cg13047869 chr3:10149882 C3orf24 -0.56 -7.93 -0.4 3.35e-14 Alzheimer's disease; CRC cis rs853679 0.550 rs1233707 chr6:28172953 G/A cg15786705 chr6:28176104 NA 0.81 11.6 0.54 2.52e-26 Depression; CRC cis rs477895 0.639 rs35858916 chr11:63950529 T/G cg23719950 chr11:63933701 MACROD1 -0.66 -8.52 -0.43 5.76e-16 Mean platelet volume; CRC cis rs7208859 0.623 rs8067338 chr17:29102345 T/C cg01831904 chr17:28903510 LRRC37B2 -0.63 -6.53 -0.34 2.51e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs7481584 0.581 rs366422 chr11:3053873 C/T cg25174290 chr11:3078921 CARS -0.42 -5.77 -0.3 1.87e-8 Calcium levels; CRC cis rs1862618 0.853 rs2113078 chr5:56087190 C/T cg22800045 chr5:56110881 MAP3K1 0.57 6.18 0.32 1.9e-9 Initial pursuit acceleration; CRC trans rs11165623 0.792 rs9437607 chr1:96977788 G/A cg10631902 chr5:14652156 NA -0.48 -8.85 -0.44 5.68e-17 Hip circumference;Waist circumference; CRC cis rs7618915 0.508 rs11717043 chr3:52656092 A/T cg08222913 chr3:52553049 STAB1 -0.34 -6.12 -0.32 2.65e-9 Bipolar disorder; CRC cis rs868943 0.554 rs34362666 chr6:116472705 C/T cg15226275 chr6:116381976 FRK 0.26 6.08 0.32 3.33e-9 Total cholesterol levels; CRC cis rs10504229 0.683 rs62621195 chr8:58133964 G/A cg05313129 chr8:58192883 C8orf71 -0.43 -6.11 -0.32 2.74e-9 Developmental language disorder (linguistic errors); CRC cis rs13191362 0.507 rs13212746 chr6:163203092 T/C cg06582575 chr6:163149167 PACRG;PARK2 0.53 8.07 0.41 1.37e-14 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs7666738 0.830 rs13121766 chr4:98935766 A/C cg17366294 chr4:99064904 C4orf37 0.43 7.2 0.37 4.22e-12 Colonoscopy-negative controls vs population controls; CRC cis rs2346177 0.844 rs13010062 chr2:46644137 C/G cg26688816 chr2:46740690 ATP6V1E2 -0.47 -6.87 -0.35 3.27e-11 HDL cholesterol; CRC cis rs561341 0.941 rs72825736 chr17:30330286 G/A cg19193384 chr17:30244184 NA -0.65 -7.58 -0.39 3.51e-13 Hip circumference adjusted for BMI; CRC cis rs853679 0.517 rs4713150 chr6:28136212 G/A cg25164649 chr6:28176230 NA 0.77 9.56 0.47 2.78e-19 Depression; CRC cis rs703842 0.616 rs7489290 chr12:58228588 C/G cg00677455 chr12:58241039 CTDSP2 0.86 13.26 0.59 1.98e-32 Multiple sclerosis; CRC cis rs2404602 0.647 rs8025991 chr15:77155268 C/T cg23625390 chr15:77176239 SCAPER -0.85 -13.53 -0.6 1.77e-33 Blood metabolite levels; CRC trans rs1656966 1.000 rs1656966 chr3:186466252 C/T cg26894523 chr4:107725 ZNF718 0.27 6.41 0.33 4.98e-10 Myopia (pathological); CRC cis rs11098499 0.730 rs78971550 chr4:120281041 C/T cg24375607 chr4:120327624 NA 0.47 7.15 0.37 5.66e-12 Corneal astigmatism; CRC cis rs11098499 0.697 rs4560394 chr4:120313435 T/G cg09307838 chr4:120376055 NA 0.69 10.57 0.5 1.09e-22 Corneal astigmatism; CRC cis rs7927592 0.956 rs10896348 chr11:68357368 T/C cg01657329 chr11:68192670 LRP5 -0.52 -8.11 -0.41 1e-14 Total body bone mineral density; CRC cis rs9488822 0.676 rs12524249 chr6:116368813 G/A cg26893134 chr6:116381904 FRK 0.26 7.6 0.39 3.03e-13 Cholesterol, total;LDL cholesterol; CRC cis rs9486715 0.867 rs2499774 chr6:97006581 C/G cg18709589 chr6:96969512 KIAA0776 -0.5 -7.47 -0.38 7.21e-13 Headache; CRC cis rs11785693 0.819 rs6994891 chr8:4989856 T/A cg26367366 chr8:4980734 NA 0.91 10.96 0.52 4.99e-24 Neuroticism (multi-trait analysis);Neuroticism; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg21890848 chr21:27107814 ATP5J;GABPA 0.39 6.35 0.33 7.17e-10 Liver disease severity in Alagille syndrome; CRC cis rs1552244 1.000 rs6764068 chr3:10153842 A/G cg00166722 chr3:10149974 C3orf24 0.7 9.17 0.45 5.23e-18 Alzheimer's disease; CRC cis rs926938 0.520 rs6671984 chr1:115257521 C/T cg12756093 chr1:115239321 AMPD1 -0.65 -9.12 -0.45 7.48e-18 Autism; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg10989441 chr1:231347308 TRIM67 0.52 7.4 0.38 1.17e-12 Response to antipsychotic treatment; CRC cis rs4604732 0.588 rs7552443 chr1:247628583 G/T cg02104434 chr1:247694406 LOC148824;OR2C3 0.54 8.15 0.41 7.85e-15 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CRC cis rs4731207 0.596 rs6466963 chr7:124572288 G/A cg23710748 chr7:124431027 NA -0.39 -6.19 -0.32 1.8e-9 Cutaneous malignant melanoma; CRC cis rs8177253 1.000 rs3811647 chr3:133484029 G/A cg11941060 chr3:133502564 NA -0.57 -9.94 -0.48 1.57e-20 Iron status biomarkers; CRC cis rs17713451 0.593 rs79901758 chr7:151268963 A/G cg18404559 chr7:151322523 PRKAG2 -0.57 -6.41 -0.33 5.12e-10 Interleukin-4 levels; CRC cis rs9902453 0.967 rs9904336 chr17:28357080 T/A cg26525008 chr17:28256777 EFCAB5;SSH2 -0.59 -8.86 -0.44 4.95e-17 Coffee consumption (cups per day); CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg01626569 chr16:20911881 LYRM1;DCUN1D3 0.39 6.24 0.33 1.34e-9 Obesity-related traits; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg14706579 chr2:203736710 ICA1L 0.39 5.99 0.31 5.41e-9 Intelligence (multi-trait analysis); CRC cis rs7640424 0.652 rs12152307 chr3:107861766 T/C cg09227934 chr3:107805635 CD47 -0.43 -6.4 -0.33 5.39e-10 Body mass index; CRC cis rs60871478 0.636 rs73045423 chr7:893952 G/A cg13798912 chr7:905769 UNC84A -0.63 -6.96 -0.36 1.9e-11 Cerebrospinal P-tau181p levels; CRC cis rs10504229 0.683 rs2318147 chr8:58114931 C/T cg21724239 chr8:58056113 NA 0.73 9.2 0.45 4.16e-18 Developmental language disorder (linguistic errors); CRC cis rs8077889 0.917 rs58283314 chr17:41905963 T/G cg26893861 chr17:41843967 DUSP3 0.87 12.21 0.56 1.52e-28 Triglycerides; CRC cis rs2953174 0.720 rs2975794 chr2:241515813 C/T cg07929629 chr2:241523174 NA 0.51 6.22 0.32 1.49e-9 Bipolar disorder; CRC cis rs7412746 0.658 rs10305711 chr1:150802996 T/C cg10589385 chr1:150898437 SETDB1 0.31 6.34 0.33 7.49e-10 Melanoma; CRC cis rs2197308 0.667 rs61920838 chr12:37856814 T/C cg26384229 chr12:38710491 ALG10B -0.64 -9.63 -0.47 1.66e-19 Morning vs. evening chronotype; CRC cis rs2013441 1.000 rs2703818 chr17:20119976 T/A cg13482628 chr17:19912719 NA -0.41 -6.45 -0.34 3.99e-10 Obesity-related traits; CRC cis rs11148252 0.583 rs9536048 chr13:52958788 T/C cg00495681 chr13:53174319 NA 0.56 7.34 0.38 1.69e-12 Lewy body disease; CRC cis rs992157 0.804 rs7559525 chr2:219150307 A/G cg00012203 chr2:219082015 ARPC2 -0.47 -7.08 -0.36 8.67e-12 Colorectal cancer; CRC cis rs3096299 0.685 rs4329923 chr16:89560178 C/T cg08392591 chr16:89556376 ANKRD11 0.43 5.81 0.31 1.44e-8 Multiple myeloma (IgH translocation); CRC cis rs57221529 0.766 rs1399381 chr5:589853 G/T cg16447950 chr5:562315 NA -0.81 -10.62 -0.51 7.76e-23 Lung disease severity in cystic fibrosis; CRC cis rs6735179 0.755 rs13421140 chr2:1774009 C/T cg26137290 chr2:1776737 NA -0.45 -5.98 -0.31 5.93e-9 Response to antipsychotic treatment; CRC cis rs17608059 0.524 rs9897978 chr17:13900256 G/T cg11395062 chr17:14139857 CDRT15 -0.41 -5.91 -0.31 8.61e-9 Temperament; CRC cis rs10229583 0.527 rs73450923 chr7:127305809 G/C cg01233922 chr7:127693937 SND1 -0.47 -7.09 -0.36 8.25e-12 Type 2 diabetes; CRC cis rs13256369 0.901 rs13251887 chr8:8568678 G/A cg00074818 chr8:8560427 CLDN23 0.4 7.2 0.37 4.04e-12 Obesity-related traits; CRC trans rs2074193 0.585 rs11183915 chr12:47770984 C/T cg10284973 chr10:77163397 C10orf41 0.49 6.27 0.33 1.1e-9 Migraine with aura; CRC cis rs7618501 0.521 rs55692411 chr3:49911155 G/A cg24110177 chr3:50126178 RBM5 -0.62 -9.42 -0.46 8.2e-19 Intelligence (multi-trait analysis); CRC cis rs1448094 0.512 rs6539927 chr12:86244486 T/C cg25456477 chr12:86230367 RASSF9 0.33 5.69 0.3 2.81e-8 Major depressive disorder; CRC cis rs9894429 0.809 rs9889642 chr17:79591762 T/C cg21028142 chr17:79581711 NPLOC4 0.39 8.62 0.43 2.8e-16 Eye color traits; CRC cis rs1348850 0.668 rs6734683 chr2:178494012 C/G cg22681709 chr2:178499509 PDE11A -0.35 -5.81 -0.3 1.49e-8 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs2333194 0.772 rs8009466 chr14:73832313 C/T cg19682024 chr14:74008259 HEATR4;ACOT1 -0.39 -5.83 -0.31 1.33e-8 Bipolar disorder with mood-incongruent psychosis; CRC cis rs7781266 0.790 rs62472378 chr7:133108979 T/C cg03336402 chr7:133662267 EXOC4 0.49 5.81 0.3 1.5e-8 Educational attainment (college completion); CRC trans rs10504390 0.519 rs75342066 chr8:66644963 T/G cg26403416 chr21:43771339 TFF2 0.53 6.04 0.32 4.25e-9 IgG glycosylation; CRC cis rs2839186 0.526 rs2839297 chr21:47921839 A/G cg05896524 chr21:47604654 C21orf56 0.46 6.9 0.36 2.73e-11 Testicular germ cell tumor; CRC cis rs2404602 0.622 rs9635380 chr15:77103479 A/G cg23625390 chr15:77176239 SCAPER -0.84 -12.52 -0.57 1.11e-29 Blood metabolite levels; CRC cis rs2180341 0.920 rs1073932 chr6:127682009 G/T cg24812749 chr6:127587940 RNF146 0.9 12.86 0.58 6.12e-31 Breast cancer; CRC cis rs10540 1.000 rs67912009 chr11:495057 G/T cg08200582 chr11:442649 ANO9 -0.68 -7.63 -0.39 2.56e-13 Body mass index; CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg16925090 chr11:101785516 KIAA1377;ANGPTL5 -0.5 -6.27 -0.33 1.13e-9 Diisocyanate-induced asthma; CRC cis rs7385804 0.796 rs10277087 chr7:100307538 C/G cg20848291 chr7:100343083 ZAN 0.48 7.44 0.38 9.12e-13 Iron status biomarkers;Mean corpuscular hemoglobin;Hematocrit;Iron status biomarkers (transferrin saturation);Red blood cell count;Iron status biomarkers (iron levels);Mean corpuscular volume;Hematological parameters; CRC cis rs2842992 0.872 rs2758330 chr6:160104844 G/T cg19482086 chr6:160211437 TCP1;MRPL18 0.69 8.6 0.43 3.33e-16 Age-related macular degeneration (geographic atrophy); CRC cis rs1538970 0.924 rs12046816 chr1:45891543 G/T cg05343316 chr1:45956843 TESK2 0.76 10.26 0.49 1.32e-21 Platelet count; CRC cis rs6089584 0.853 rs1746280 chr20:60577821 C/G cg23463467 chr20:60627584 TAF4 0.34 5.71 0.3 2.49e-8 Body mass index; CRC cis rs1799949 0.965 rs34616041 chr17:41188786 G/A cg23758822 chr17:41437982 NA 0.82 13.33 0.59 1e-32 Menopause (age at onset); CRC cis rs17767392 0.881 rs35866366 chr14:71849185 A/G cg13720639 chr14:72061746 SIPA1L1 -0.48 -6.12 -0.32 2.72e-9 Mitral valve prolapse; CRC cis rs10504229 0.683 rs7464038 chr8:58111908 T/C cg05313129 chr8:58192883 C8orf71 -0.45 -6.07 -0.32 3.55e-9 Developmental language disorder (linguistic errors); CRC cis rs2268241 0.877 rs17885509 chr21:34779630 C/T cg14850771 chr21:34775459 IFNGR2 0.77 9.64 0.47 1.6e-19 Obesity-related traits; CRC trans rs1455244 0.700 rs7229302 chr18:11508904 G/T cg23104227 chr2:70781287 TGFA 0.39 6.15 0.32 2.25e-9 Schizophrenia; CRC cis rs12477438 0.765 rs2309521 chr2:99592069 C/T cg26064155 chr2:99771622 LIPT1;TSGA10 -0.63 -8.56 -0.43 4.4e-16 Chronic sinus infection; CRC cis rs875971 1.000 rs6963646 chr7:65685767 T/C cg18876405 chr7:65276391 NA -0.54 -9.31 -0.46 1.84e-18 Aortic root size; CRC cis rs3858526 0.584 rs10734560 chr11:5864503 G/T cg26762873 chr11:5879799 OR52E8 -0.48 -7.25 -0.37 2.95e-12 DNA methylation (variation); CRC cis rs9911578 1.000 rs8067571 chr17:56868856 C/T cg05425664 chr17:57184151 TRIM37 -0.48 -7.44 -0.38 8.69e-13 Intelligence (multi-trait analysis); CRC cis rs9992667 0.910 rs10019144 chr4:38686405 C/T cg19726192 chr4:38663646 FLJ13197 -0.68 -8.78 -0.44 9.27e-17 Eosinophil percentage of granulocytes; CRC cis rs12188164 0.965 rs41282625 chr5:475626 C/G cg21972741 chr5:435613 AHRR 0.56 7.66 0.39 2.03e-13 Cystic fibrosis severity; CRC cis rs4731207 0.698 rs7782340 chr7:124506025 A/C cg23710748 chr7:124431027 NA -0.38 -6.08 -0.32 3.42e-9 Cutaneous malignant melanoma; CRC cis rs9311474 0.629 rs11709284 chr3:52559705 G/A cg18591801 chr3:52553433 STAB1 -0.32 -6.15 -0.32 2.21e-9 Electroencephalogram traits; CRC cis rs977987 0.771 rs12929673 chr16:75470295 C/T cg03315344 chr16:75512273 CHST6 0.56 9.58 0.47 2.43e-19 Dupuytren's disease; CRC cis rs7615952 0.641 rs12495947 chr3:125771698 C/T cg18479299 chr3:125709523 NA -0.55 -6.58 -0.34 1.86e-10 Blood pressure (smoking interaction); CRC cis rs3785574 0.962 rs2584630 chr17:61887561 T/A cg22520471 chr17:61851767 DDX42;CCDC47 0.46 6.35 0.33 7.03e-10 Height; CRC cis rs951366 0.903 rs823116 chr1:205720483 G/A cg07167872 chr1:205819463 PM20D1 0.46 6.84 0.35 3.9e-11 Menarche (age at onset); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg03543731 chr15:50474621 SLC27A2 0.45 6.3 0.33 9.73e-10 Response to antipsychotic treatment; CRC cis rs9522267 0.535 rs4644738 chr13:112235995 G/A cg26182253 chr13:112236782 NA 0.31 6.33 0.33 7.97e-10 Hepatitis; CRC cis rs7666738 0.830 rs28795113 chr4:98951331 A/G cg05340658 chr4:99064831 C4orf37 0.61 9.54 0.47 3.45e-19 Colonoscopy-negative controls vs population controls; CRC cis rs4891159 0.790 rs7234653 chr18:74111988 C/T cg24786174 chr18:74118243 ZNF516 -0.91 -17.05 -0.68 3.72e-47 Longevity; CRC cis rs7827545 1.000 rs7823948 chr8:135566580 G/A cg17885191 chr8:135476712 NA 0.53 7.27 0.37 2.61e-12 Hypertension (SNP x SNP interaction); CRC cis rs10463316 0.894 rs7727770 chr5:150767116 G/T cg03212797 chr5:150827313 SLC36A1 -0.5 -7.85 -0.4 6.1e-14 Metabolite levels (Pyroglutamine); CRC cis rs12477438 0.765 rs7607578 chr2:99669771 G/A cg26064155 chr2:99771622 LIPT1;TSGA10 -0.63 -8.55 -0.43 4.61e-16 Chronic sinus infection; CRC cis rs9649213 0.586 rs55648546 chr7:97960800 G/A cg09267113 chr7:98030324 BAIAP2L1 -0.93 -12.06 -0.55 5.5e-28 Prostate cancer (SNP x SNP interaction); CRC cis rs1005277 0.540 rs2224248 chr10:38451886 A/G cg25517755 chr10:38738941 LOC399744 -0.42 -6.1 -0.32 3.03e-9 Extrinsic epigenetic age acceleration; CRC cis rs2243480 1.000 rs1701758 chr7:65470201 T/A cg12463550 chr7:65579703 CRCP 0.65 6.2 0.32 1.67e-9 Diabetic kidney disease; CRC cis rs25422 0.887 rs9481844 chr6:118990941 G/A cg22561889 chr6:118971681 C6orf204 0.44 6.1 0.32 2.9e-9 Renal cell carcinoma; CRC trans rs2797160 1.000 rs1739347 chr6:126014157 C/T cg05039488 chr6:79577232 IRAK1BP1 0.51 7.56 0.38 3.95e-13 Endometrial cancer; CRC cis rs12451471 0.667 rs12942002 chr17:78101629 C/G cg24585782 chr17:78113791 EIF4A3 -0.52 -7.11 -0.37 7.06e-12 Plateletcrit;Mean corpuscular hemoglobin concentration; CRC trans rs35110281 0.667 rs7282405 chr21:45123611 C/G cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.42 6.63 0.34 1.38e-10 Mean corpuscular volume; CRC cis rs4713118 0.662 rs9468278 chr6:28028482 C/T cg15786705 chr6:28176104 NA 0.69 9.22 0.45 3.53e-18 Parkinson's disease; CRC cis rs4332037 0.707 rs56070303 chr7:1891015 C/T cg25834613 chr7:1915315 MAD1L1 -0.4 -6.21 -0.32 1.56e-9 Bipolar disorder; CRC cis rs1401999 0.966 rs2313212 chr3:183700928 A/G cg01324343 chr3:183735012 ABCC5 0.8 14.61 0.63 1.34e-37 Anterior chamber depth; CRC cis rs4713118 0.539 rs200988 chr6:27819353 A/C cg12273811 chr6:28175739 NA 0.54 7.59 0.39 3.36e-13 Parkinson's disease; CRC cis rs72781680 1.000 rs12616899 chr2:24165235 A/G cg08917208 chr2:24149416 ATAD2B 0.91 9.24 0.45 3.06e-18 Lymphocyte counts; CRC cis rs1862618 0.754 rs252899 chr5:56188569 G/C cg18230493 chr5:56204884 C5orf35 -0.76 -9.41 -0.46 9.04e-19 Initial pursuit acceleration; CRC cis rs2067615 0.524 rs10778499 chr12:107068387 C/T cg13491945 chr12:107078410 RFX4 0.36 6.16 0.32 2.18e-9 Heart rate; CRC cis rs2749592 0.550 rs7081464 chr10:37883937 C/T cg25427524 chr10:38739819 LOC399744 0.66 10.92 0.52 6.95e-24 Age-related hearing impairment (SNP x SNP interaction); CRC trans rs2303319 0.504 rs1515182 chr2:162436934 A/G cg18122310 chr12:50236657 BCDIN3D -0.73 -6.01 -0.31 4.93e-9 Cognitive function; CRC cis rs9796 0.835 rs3100807 chr15:41292206 G/A cg18705301 chr15:41695430 NDUFAF1 0.34 5.74 0.3 2.12e-8 Menopause (age at onset); CRC cis rs780096 0.546 rs6547626 chr2:27646770 C/T cg22903471 chr2:27725779 GCKR -0.37 -6.07 -0.32 3.43e-9 Total body bone mineral density; CRC cis rs597539 0.652 rs613128 chr11:68638058 G/T cg04772025 chr11:68637568 NA 0.51 8.11 0.41 1.04e-14 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs6860806 0.507 rs273912 chr5:131661349 A/C cg02033258 chr5:131593261 PDLIM4 -0.38 -6.49 -0.34 3.23e-10 Breast cancer; CRC cis rs7043114 0.525 rs7864630 chr9:95267560 A/C cg14631576 chr9:95140430 CENPP -0.31 -5.85 -0.31 1.16e-8 Height; CRC cis rs875971 0.862 rs4718319 chr7:65652784 C/A cg12463550 chr7:65579703 CRCP -0.54 -7.69 -0.39 1.73e-13 Aortic root size; CRC cis rs1223397 0.651 rs2496145 chr6:13312293 C/T cg07912922 chr6:13274314 PHACTR1 -0.38 -5.97 -0.31 6.18e-9 Blood pressure; CRC cis rs9463078 0.677 rs6458423 chr6:45140645 C/T cg25276700 chr6:44698697 NA -0.24 -5.91 -0.31 8.45e-9 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; CRC cis rs2559856 1.000 rs10860771 chr12:102087242 A/G cg12924262 chr12:102091054 CHPT1 0.55 8.26 0.41 3.58e-15 Blood protein levels; CRC cis rs9649213 0.593 rs6465672 chr7:97963717 C/T cg21770322 chr7:97807741 LMTK2 -0.49 -8.0 -0.4 2.19e-14 Prostate cancer (SNP x SNP interaction); CRC cis rs7085104 0.632 rs3781287 chr10:104595420 A/C cg04362960 chr10:104952993 NT5C2 0.59 8.49 0.42 7.05e-16 Immature fraction of reticulocytes;Schizophrenia; CRC cis rs6502050 0.871 rs6502051 chr17:80059332 A/C cg19223190 chr17:80058835 NA -0.46 -7.35 -0.38 1.57e-12 Life satisfaction; CRC cis rs208520 0.690 rs207118 chr6:66788948 T/A cg07460842 chr6:66804631 NA -1.09 -15.38 -0.65 1.37e-40 Exhaled nitric oxide output; CRC cis rs12681288 0.676 rs2600514 chr8:994175 G/A cg15309053 chr8:964076 NA 0.4 6.78 0.35 5.49e-11 Schizophrenia; CRC cis rs4684776 0.676 rs35975472 chr3:11292653 T/G cg00170343 chr3:11313890 ATG7 -0.5 -5.89 -0.31 9.55e-9 Small vessel stroke; CRC trans rs6089829 1.000 rs6089828 chr20:61668998 C/T cg23505145 chr19:12996616 KLF1 0.49 7.86 0.4 5.42e-14 Prostate cancer (SNP x SNP interaction); CRC cis rs2032447 0.839 rs9356995 chr6:25996673 G/A cg26028573 chr6:26043587 HIST1H2BB 0.47 6.98 0.36 1.61e-11 Intelligence (multi-trait analysis); CRC cis rs2153535 0.580 rs2152347 chr6:8474281 A/G cg07606381 chr6:8435919 SLC35B3 0.67 10.7 0.51 4.01e-23 Motion sickness; CRC cis rs10256972 0.567 rs2949185 chr7:1209013 A/G cg16145915 chr7:1198662 ZFAND2A -0.51 -10.52 -0.5 1.63e-22 Longevity;Endometriosis; CRC cis rs9467711 0.651 rs35378061 chr6:26059157 C/A cg19084075 chr6:26124329 HIST1H2AC;HIST1H2BC 0.74 6.43 0.33 4.43e-10 Autism spectrum disorder or schizophrenia; CRC cis rs72781680 1.000 rs56205282 chr2:24221317 C/T cg08917208 chr2:24149416 ATAD2B 1.03 9.91 0.48 2.04e-20 Lymphocyte counts; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg07572592 chr17:73937177 FBF1 0.44 6.1 0.32 2.91e-9 Response to antipsychotic treatment; CRC trans rs1997103 0.705 rs56301138 chr7:55396555 G/T cg20935933 chr6:143382018 AIG1 0.52 6.73 0.35 7.57e-11 QRS interval (sulfonylurea treatment interaction); CRC cis rs17711722 0.510 rs11767457 chr7:65290615 C/T cg18876405 chr7:65276391 NA 0.5 8.01 0.4 1.96e-14 Calcium levels; CRC cis rs8180040 0.966 rs11130128 chr3:47486632 T/C cg10298567 chr3:47292165 KIF9 0.37 6.05 0.32 3.93e-9 Colorectal cancer; CRC cis rs6940638 0.688 rs9393790 chr6:27114052 A/C cg12292205 chr6:26970375 C6orf41 0.5 6.73 0.35 7.65e-11 Intelligence (multi-trait analysis); CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg18724032 chr3:171758176 FNDC3B -0.37 -6.16 -0.32 2.11e-9 Myopia (pathological); CRC cis rs3101457 0.515 rs4658628 chr1:244516090 T/C cg09033006 chr1:244517177 C1orf100 -0.44 -6.26 -0.33 1.2e-9 Smoking behavior; CRC cis rs713477 0.505 rs4901561 chr14:55888578 T/C cg13175173 chr14:55914753 NA -0.46 -7.3 -0.37 2.24e-12 Pediatric bone mineral content (femoral neck); CRC cis rs2370759 1.000 rs79487858 chr10:32616405 T/C cg01819863 chr10:32635814 EPC1 1.1 13.26 0.59 1.87e-32 Sexual dysfunction (female); CRC cis rs2502731 0.561 rs3003606 chr9:130982416 C/T cg13642260 chr9:130955380 CIZ1 0.42 6.63 0.34 1.36e-10 Attention deficit hyperactivity disorder; CRC trans rs7395662 0.963 rs6485906 chr11:48651661 T/C cg21153622 chr11:89784906 NA -0.48 -7.77 -0.39 1e-13 HDL cholesterol; CRC cis rs1728785 1.000 rs1645981 chr16:68571648 T/C cg02972257 chr16:68554789 NA -0.58 -7.15 -0.37 5.78e-12 Ulcerative colitis; CRC cis rs6961069 0.806 rs11770907 chr7:80258630 G/A cg04458919 chr7:80252533 CD36 0.34 5.98 0.31 5.72e-9 Platelet count; CRC cis rs78456975 1.000 rs55761535 chr2:1561450 A/G cg26248373 chr2:1572462 NA -0.66 -7.19 -0.37 4.36e-12 Placebo response in major depressive disorder (% change in symptom score); CRC cis rs798554 0.959 rs798556 chr7:2759002 C/A cg19717773 chr7:2847554 GNA12 -0.45 -6.59 -0.34 1.7e-10 Height; CRC trans rs1814175 0.817 rs28679516 chr11:50055998 G/A cg03929089 chr4:120376271 NA -0.93 -17.98 -0.7 7.84e-51 Height; CRC cis rs13108904 0.935 rs1732102 chr4:1277924 T/C cg20887711 chr4:1340912 KIAA1530 -0.47 -7.02 -0.36 1.24e-11 Obesity-related traits; CRC cis rs13217239 0.646 rs10946898 chr6:27003884 T/C cg12292205 chr6:26970375 C6orf41 0.56 9.42 0.46 8.08e-19 Schizophrenia; CRC cis rs873946 0.586 rs12776770 chr10:134564831 T/C cg26818010 chr10:134567672 INPP5A -0.65 -8.86 -0.44 5.21e-17 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CRC cis rs4689592 0.513 rs2358718 chr4:7068743 A/C cg19539972 chr4:7069911 GRPEL1 -0.76 -9.59 -0.47 2.32e-19 Monocyte percentage of white cells; CRC cis rs801193 0.904 rs4718405 chr7:66254646 A/G cg18876405 chr7:65276391 NA 0.58 10.59 0.5 9.48e-23 Aortic root size; CRC trans rs3942852 0.774 rs924715 chr11:48181060 G/A cg03929089 chr4:120376271 NA -0.72 -9.05 -0.45 1.27e-17 Acute lymphoblastic leukemia (childhood); CRC cis rs59698941 0.527 rs11742089 chr5:132178930 G/A cg14825688 chr5:132208181 LEAP2 -0.38 -5.91 -0.31 8.62e-9 Apolipoprotein A-IV levels; CRC trans rs75804782 0.641 rs72987328 chr2:239360097 C/T cg01134436 chr17:81009848 B3GNTL1 0.72 6.57 0.34 1.97e-10 Morning vs. evening chronotype;Chronotype; CRC trans rs5756813 0.661 rs6000898 chr22:38202399 T/C cg19894588 chr14:64061835 NA -0.62 -8.41 -0.42 1.3e-15 Optic cup area;Vertical cup-disc ratio; CRC trans rs7726839 0.540 rs61580655 chr5:597564 A/G cg11887960 chr12:57824829 NA 0.59 6.68 0.35 1.01e-10 Obesity-related traits; CRC trans rs877282 1.000 rs12775643 chr10:773242 G/A cg22713356 chr15:30763199 NA 1.15 14.73 0.63 4.62e-38 Uric acid levels; CRC cis rs11679072 1.000 rs56986149 chr2:240450869 T/G cg03276489 chr2:240449683 NA -0.91 -8.95 -0.44 2.69e-17 Blood pressure (smoking interaction); CRC cis rs7932354 0.583 rs10742784 chr11:46899282 G/A cg19486271 chr11:47235900 DDB2 -0.42 -6.35 -0.33 7.28e-10 Bone mineral density (hip);Bone mineral density; CRC cis rs4474465 0.850 rs4945289 chr11:78245334 G/T cg27205649 chr11:78285834 NARS2 0.51 6.59 0.34 1.76e-10 Alzheimer's disease (survival time); CRC cis rs4700695 0.841 rs152994 chr5:65262989 A/G cg21114390 chr5:65439923 SFRS12 0.57 6.88 0.35 3.05e-11 Facial morphology (factor 19); CRC cis rs67311347 1.000 rs9857824 chr3:40459412 A/G cg09455208 chr3:40491958 NA 0.49 9.71 0.47 9.45e-20 Renal cell carcinoma; CRC cis rs7208859 0.623 rs11651858 chr17:29170718 A/G cg13385521 chr17:29058706 SUZ12P 0.69 8.01 0.4 2.06e-14 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs9522267 0.737 rs7330902 chr13:112227599 C/T cg10483660 chr13:112241077 NA -0.41 -7.19 -0.37 4.36e-12 Hepatitis; CRC trans rs2303319 0.504 rs56009150 chr2:162598582 T/C cg22988483 chr14:93581567 ITPK1 -0.66 -6.05 -0.32 4.02e-9 Cognitive function; CRC trans rs4824093 0.610 rs73443974 chr22:50314316 G/A cg09872104 chr7:134855509 C7orf49 -0.87 -8.4 -0.42 1.33e-15 Amyotrophic lateral sclerosis (sporadic); CRC trans rs28735056 0.609 rs4799099 chr18:77639585 A/G cg05926928 chr17:57297772 GDPD1 0.46 6.64 0.34 1.33e-10 Schizophrenia; CRC cis rs9479482 1.000 rs5017316 chr6:150333489 A/T cg25797454 chr6:150327115 RAET1K 0.35 6.26 0.33 1.2e-9 Alopecia areata; CRC cis rs6502050 0.835 rs62080004 chr17:80079079 C/T cg11859384 chr17:80120422 CCDC57 0.37 5.77 0.3 1.85e-8 Life satisfaction; CRC cis rs736408 0.562 rs13071584 chr3:52804487 T/C cg08222913 chr3:52553049 STAB1 -0.34 -6.29 -0.33 1.02e-9 Bipolar disorder; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg04565464 chr8:145669602 NFKBIL2 0.41 6.68 0.35 9.97e-11 Liver disease severity in Alagille syndrome; CRC cis rs6840360 0.571 rs4696273 chr4:152528477 G/A cg09659197 chr4:152720779 NA 0.32 5.75 0.3 1.99e-8 Intelligence (multi-trait analysis); CRC trans rs2832077 0.527 rs2832116 chr21:30228368 C/A cg14791747 chr16:20752902 THUMPD1 0.67 10.89 0.51 8.9e-24 Cognitive test performance; CRC cis rs34172651 0.517 rs11639856 chr16:24788645 A/T cg00339695 chr16:24857497 SLC5A11 -0.42 -8.63 -0.43 2.59e-16 Intelligence (multi-trait analysis); CRC cis rs478304 0.651 rs11227299 chr11:65549570 C/G cg27068330 chr11:65405492 SIPA1 -0.64 -9.5 -0.46 4.39e-19 Acne (severe); CRC cis rs17065868 0.764 rs9533864 chr13:45037165 A/G cg10246903 chr13:45222710 NA 0.54 5.69 0.3 2.79e-8 Antineutrophil cytoplasmic antibody-associated vasculitis; CRC cis rs501120 0.564 rs12415866 chr10:44686664 A/G cg09554077 chr10:44749378 NA 0.55 7.67 0.39 1.95e-13 Coronary artery disease;Coronary heart disease; CRC cis rs1552244 0.572 rs6797536 chr3:10168802 C/T cg10729496 chr3:10149963 C3orf24 -0.5 -5.96 -0.31 6.38e-9 Alzheimer's disease; CRC cis rs7727544 0.507 rs10051679 chr5:131570931 T/A cg20512303 chr5:131592959 PDLIM4 0.38 7.0 0.36 1.45e-11 Blood metabolite levels; CRC cis rs4332037 0.615 rs62435134 chr7:1895463 T/G cg02421172 chr7:1938701 MAD1L1 0.43 5.87 0.31 1.09e-8 Bipolar disorder; CRC cis rs730566 1.000 rs730566 chr3:48487048 G/T cg07636037 chr3:49044803 WDR6 -0.51 -6.0 -0.31 5.31e-9 Prion diseases; CRC cis rs501120 0.564 rs11238907 chr10:44687780 T/G cg09554077 chr10:44749378 NA 0.5 6.86 0.35 3.5e-11 Coronary artery disease;Coronary heart disease; CRC cis rs2408955 0.561 rs9971924 chr12:48479832 C/G cg21466736 chr12:48725269 NA 0.46 7.12 0.37 6.72e-12 Glycated hemoglobin levels; CRC trans rs57221529 0.766 rs17497684 chr5:558307 T/C cg11887960 chr12:57824829 NA 0.58 6.45 0.34 3.94e-10 Lung disease severity in cystic fibrosis; CRC trans rs1814175 0.791 rs10769593 chr11:49616217 T/C cg03929089 chr4:120376271 NA -0.93 -17.47 -0.69 8.15e-49 Height; CRC cis rs9457247 1.000 rs2769354 chr6:167379771 G/T cg23791538 chr6:167370224 RNASET2 0.39 6.09 0.32 3.22e-9 Crohn's disease; CRC cis rs977987 0.806 rs8056236 chr16:75448273 C/T cg03315344 chr16:75512273 CHST6 0.54 9.08 0.45 1.04e-17 Dupuytren's disease; CRC cis rs2204008 0.869 rs34438288 chr12:38211582 G/T cg26384229 chr12:38710491 ALG10B 0.69 9.26 0.45 2.81e-18 Bladder cancer; CRC cis rs7666738 0.830 rs17484890 chr4:99013778 T/C cg17366294 chr4:99064904 C4orf37 0.43 7.23 0.37 3.41e-12 Colonoscopy-negative controls vs population controls; CRC cis rs881375 0.967 rs1014529 chr9:123684943 C/G cg09419670 chr9:123605666 PSMD5;LOC253039 0.57 8.32 0.42 2.37e-15 Rheumatoid arthritis; CRC cis rs1005277 0.522 rs9417256 chr10:37976990 A/G cg25517755 chr10:38738941 LOC399744 -0.42 -6.09 -0.32 3.22e-9 Extrinsic epigenetic age acceleration; CRC cis rs17092148 0.887 rs2889849 chr20:33164277 A/G cg08999081 chr20:33150536 PIGU 0.48 5.92 0.31 8.25e-9 Neuroticism; CRC cis rs4563143 0.514 rs73030738 chr19:29312328 G/A cg14983838 chr19:29218262 NA 0.48 6.46 0.34 3.79e-10 Methadone dose in opioid dependence; CRC trans rs9585327 0.584 rs4772260 chr13:100645723 A/G cg07121733 chr10:123734241 NSMCE4A 0.38 6.07 0.32 3.56e-9 Myopia; CRC cis rs4819052 0.765 rs2838852 chr21:46677037 C/A cg11663144 chr21:46675770 NA -0.86 -14.62 -0.63 1.26e-37 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs9611565 0.512 rs7291736 chr22:42124874 C/A cg03806693 chr22:41940476 POLR3H 1.06 13.33 0.59 1.06e-32 Vitiligo; CRC cis rs9733 0.536 rs10888385 chr1:150574302 T/C cg17724175 chr1:150552817 MCL1 -0.52 -8.46 -0.42 8.99e-16 Tonsillectomy; CRC cis rs7659604 0.935 rs73844280 chr4:122664687 G/A cg06713675 chr4:122721982 EXOSC9 -0.38 -6.26 -0.33 1.17e-9 Type 2 diabetes; CRC cis rs2070488 0.932 rs4678604 chr3:38444273 G/A cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.9 16.47 0.67 7.29e-45 Electrocardiographic conduction measures; CRC cis rs853679 0.517 rs6922063 chr6:28094366 G/A cg02631126 chr6:28058918 ZSCAN12L1 0.28 5.68 0.3 2.9e-8 Depression; CRC cis rs9611565 0.513 rs739135 chr22:42090069 A/C cg03806693 chr22:41940476 POLR3H 1.06 13.33 0.59 1.06e-32 Vitiligo; CRC cis rs9517313 0.591 rs17574543 chr13:99172893 G/A cg07423050 chr13:99094983 FARP1 -0.57 -8.05 -0.41 1.53e-14 Neuroticism; CRC cis rs9372498 0.536 rs9489460 chr6:118925754 C/T cg15382696 chr6:118971807 C6orf204 0.59 7.43 0.38 9.32e-13 Diastolic blood pressure; CRC cis rs9916302 0.904 rs6503506 chr17:37524653 C/A cg15445000 chr17:37608096 MED1 -0.42 -9.13 -0.45 7.24e-18 Glomerular filtration rate (creatinine); CRC cis rs9486715 1.000 rs6905737 chr6:97066659 A/T cg18709589 chr6:96969512 KIAA0776 -0.48 -6.8 -0.35 5.03e-11 Headache; CRC cis rs9549367 0.789 rs9549715 chr13:113908240 G/C cg00898013 chr13:113819073 PROZ -0.47 -6.54 -0.34 2.29e-10 Platelet distribution width; CRC cis rs909674 0.524 rs5757670 chr22:39829736 G/A cg05872129 chr22:39784769 NA -0.62 -12.2 -0.56 1.65e-28 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; CRC cis rs853679 0.542 rs34131763 chr6:28075000 A/C cg23161317 chr6:28129485 ZNF389 0.52 6.38 0.33 6.1e-10 Depression; CRC cis rs2857891 0.909 rs17191140 chr11:6944283 G/A cg04053776 chr11:6947353 ZNF215 0.49 6.56 0.34 2.12e-10 Response to cytadine analogues (cytosine arabinoside); CRC cis rs6834538 0.894 rs34712587 chr4:113485894 A/T cg10021238 chr4:113569128 MIR367;LARP7 -0.46 -6.46 -0.34 3.69e-10 Free thyroxine concentration; CRC cis rs9916302 0.904 rs8070695 chr17:37478062 C/T cg00129232 chr17:37814104 STARD3 0.53 7.71 0.39 1.51e-13 Glomerular filtration rate (creatinine); CRC cis rs12142240 0.698 rs6696777 chr1:46810970 A/G cg00530320 chr1:46809349 NSUN4 0.57 7.79 0.39 8.88e-14 Menopause (age at onset); CRC cis rs5750830 0.649 rs2413590 chr22:39790191 G/C cg24399712 chr22:39784796 NA -0.48 -9.16 -0.45 5.86e-18 Intelligence (multi-trait analysis); CRC trans rs7395662 0.963 rs115181013 chr11:48575801 T/C cg21153622 chr11:89784906 NA -0.44 -7.1 -0.36 7.56e-12 HDL cholesterol; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg08451598 chr22:50220343 NA 0.45 6.09 0.32 3.19e-9 Anxiety disorder; CRC cis rs2839186 0.708 rs17183123 chr21:47671961 G/C cg05896524 chr21:47604654 C21orf56 0.47 7.06 0.36 9.72e-12 Testicular germ cell tumor; CRC cis rs2839186 0.708 rs6518285 chr21:47644667 T/C cg11766577 chr21:47581405 C21orf56 -0.52 -8.46 -0.42 8.8e-16 Testicular germ cell tumor; CRC cis rs8180040 0.627 rs6442059 chr3:47187075 C/G cg27129171 chr3:47204927 SETD2 0.72 11.38 0.53 1.64e-25 Colorectal cancer; CRC cis rs9896933 0.775 rs615630 chr17:80730527 T/C cg02398342 chr17:80708632 TBCD;FN3K -0.6 -6.82 -0.35 4.25e-11 Bone mineral accretion in asthma (oral corticosteroid dose interaction); CRC cis rs3760982 1.000 rs4803658 chr19:44290013 T/A cg11993925 chr19:44307056 LYPD5 0.47 7.72 0.39 1.4e-13 Breast cancer (estrogen-receptor negative);Breast cancer; CRC cis rs7586879 0.681 rs6545790 chr2:25109302 A/G cg04586622 chr2:25135609 ADCY3 -0.53 -9.82 -0.48 4.06e-20 Body mass index; CRC cis rs6772849 0.896 rs61112519 chr3:128338176 T/A cg08795948 chr3:128337044 NA 0.35 6.09 0.32 3.15e-9 Monocyte percentage of white cells;Monocyte count; CRC cis rs9322193 0.736 rs10457851 chr6:150096352 T/A cg13206674 chr6:150067644 NUP43 0.57 8.14 0.41 8.29e-15 Lung cancer; CRC cis rs59918340 0.548 rs10102728 chr8:142205964 G/A cg23750338 chr8:142222470 SLC45A4 0.61 10.78 0.51 2.14e-23 Immature fraction of reticulocytes; CRC cis rs10751667 1.000 rs7395632 chr11:958789 C/T cg01483505 chr11:975446 AP2A2 -0.38 -5.69 -0.3 2.78e-8 Alzheimer's disease (late onset); CRC trans rs656319 0.647 rs13264668 chr8:9884877 C/T cg16141378 chr3:129829833 LOC729375 0.41 5.99 0.31 5.62e-9 Myopia (pathological); CRC cis rs34172651 0.517 rs3803716 chr16:24802325 C/T cg02428538 chr16:24856791 SLC5A11 -0.56 -6.6 -0.34 1.68e-10 Intelligence (multi-trait analysis); CRC cis rs7617480 0.648 rs4858830 chr3:48734002 T/C cg07636037 chr3:49044803 WDR6 0.71 8.88 0.44 4.56e-17 Subjective well-being (multi-trait analysis);Menarche (age at onset); CRC cis rs7020830 0.825 rs7036132 chr9:37317241 A/G cg14294708 chr9:37120828 ZCCHC7 1.13 22.84 0.78 7.36e-70 Schizophrenia; CRC trans rs2243480 1.000 rs7456042 chr7:65299778 T/C cg10756647 chr7:56101905 PSPH 0.74 7.77 0.39 9.91e-14 Diabetic kidney disease; CRC cis rs2439831 0.867 rs12443102 chr15:43932103 G/C cg02155558 chr15:43621948 ADAL;LCMT2 0.7 7.58 0.39 3.45e-13 Lung cancer in ever smokers; CRC cis rs13191362 1.000 rs13213408 chr6:162998049 A/T cg23758597 chr6:163146217 PARK2 -0.55 -6.12 -0.32 2.7e-9 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC trans rs1005277 0.505 rs200936 chr10:38134935 T/C cg17830980 chr10:43048298 ZNF37B -0.41 -6.38 -0.33 6.11e-10 Extrinsic epigenetic age acceleration; CRC trans rs12495832 0.778 rs56270789 chr3:147912859 G/A cg10221266 chr7:153579447 NA 0.57 6.17 0.32 2.05e-9 Chin dimples; CRC cis rs11628318 0.614 rs1190337 chr14:103106159 A/C cg23461800 chr14:103021989 NA -0.71 -8.08 -0.41 1.28e-14 Platelet count; CRC cis rs7849270 1.000 rs7869804 chr9:131913144 C/T cg13538475 chr9:131942899 NA -0.29 -5.75 -0.3 2e-8 Blood metabolite ratios; CRC cis rs9486719 0.948 rs11152953 chr6:96894305 C/T cg06623918 chr6:96969491 KIAA0776 -0.81 -9.51 -0.46 4.17e-19 Migraine;Coronary artery disease; CRC cis rs11123170 0.569 rs1049137 chr2:113975110 A/G cg21550016 chr2:113992930 PAX8;LOC440839;LOC654433 0.51 6.06 0.32 3.72e-9 Renal function-related traits (BUN); CRC cis rs9467711 0.659 rs66941101 chr6:26530376 C/T cg08501292 chr6:25962987 TRIM38 0.88 6.11 0.32 2.84e-9 Autism spectrum disorder or schizophrenia; CRC cis rs11098499 0.954 rs12507964 chr4:120413061 T/A cg24375607 chr4:120327624 NA 0.49 7.5 0.38 6.06e-13 Corneal astigmatism; CRC trans rs9858542 1.000 rs11709525 chr3:49690496 C/T cg21659725 chr3:3221576 CRBN -0.7 -9.18 -0.45 5.01e-18 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs10208940 0.920 rs13417100 chr2:68821725 C/T cg12452813 chr2:68675892 NA -0.45 -5.64 -0.3 3.75e-8 Urate levels in lean individuals; CRC cis rs611744 0.608 rs612744 chr8:109245991 G/A cg21045802 chr8:109455806 TTC35 0.43 6.72 0.35 7.79e-11 Dupuytren's disease; CRC cis rs7312933 0.558 rs11181463 chr12:42763636 C/T cg19980929 chr12:42632907 YAF2 0.42 6.35 0.33 7.08e-10 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CRC cis rs7104764 0.507 rs7121085 chr11:258523 A/G cg00562011 chr11:252351 PSMD13 -0.54 -6.33 -0.33 8.18e-10 Menarche (age at onset); CRC cis rs6867032 1.000 rs28392808 chr5:2013477 A/G cg26168224 chr5:2018326 NA 0.98 17.95 0.7 1.01e-50 Gut microbiome composition (winter); CRC cis rs908922 0.676 rs1572533 chr1:152509742 T/C cg09873164 chr1:152488093 CRCT1 0.38 6.34 0.33 7.77e-10 Hair morphology; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg01334186 chr1:151372572 PSMB4 0.53 7.06 0.36 9.77e-12 Thyroid stimulating hormone; CRC trans rs208520 0.742 rs208454 chr6:66907783 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.9 -11.28 -0.53 3.66e-25 Exhaled nitric oxide output; CRC cis rs9325144 0.671 rs7485963 chr12:38768254 C/G cg26384229 chr12:38710491 ALG10B -0.51 -7.46 -0.38 7.89e-13 Morning vs. evening chronotype; CRC cis rs7119 0.651 rs12902072 chr15:77848732 T/C cg27398640 chr15:77910606 LINGO1 -0.43 -7.13 -0.37 6.55e-12 Type 2 diabetes; CRC cis rs9303401 0.614 rs62084384 chr17:57126842 G/A cg02118635 chr17:56770003 RAD51C;TEX14 0.77 9.29 0.46 2.14e-18 Cognitive test performance; CRC cis rs2084637 1.000 rs11605335 chr11:122390754 C/A cg21585512 chr11:122030076 LOC399959 -0.38 -6.74 -0.35 7e-11 Stroke; CRC cis rs7605827 0.930 rs4668918 chr2:15661992 A/T cg19274914 chr2:15703543 NA 0.39 5.91 0.31 8.66e-9 Educational attainment (years of education); CRC trans rs11722228 0.508 rs3796825 chr4:10092879 T/A cg26043149 chr18:55253948 FECH 1.12 17.34 0.69 2.69e-48 Gout;Urate levels;Serum uric acid levels; CRC cis rs7614311 0.681 rs73117042 chr3:63896543 T/C cg22134162 chr3:63841271 THOC7 -0.58 -5.85 -0.31 1.18e-8 Lung function (FVC);Lung function (FEV1); CRC cis rs875971 1.000 rs4718357 chr7:65960878 A/G cg18876405 chr7:65276391 NA 0.51 8.78 0.44 9.39e-17 Aortic root size; CRC cis rs77972916 0.505 rs6736400 chr2:43500804 A/G cg06169590 chr2:43455088 ZFP36L2;LOC100129726 -0.66 -7.77 -0.39 1.01e-13 Granulocyte percentage of myeloid white cells; CRC cis rs10751667 0.666 rs7396059 chr11:970490 C/A cg23136738 chr11:925521 AP2A2 -0.43 -7.2 -0.37 4.09e-12 Alzheimer's disease (late onset); CRC cis rs4332037 0.901 rs7791899 chr7:1935988 T/C cg02421172 chr7:1938701 MAD1L1 0.44 6.0 0.31 5.23e-9 Bipolar disorder; CRC cis rs62007496 0.520 rs73358643 chr14:103612707 C/T cg09274347 chr14:103599552 TNFAIP2 0.54 5.81 0.31 1.45e-8 Language performance in older adults (adjusted for episodic memory); CRC cis rs1057239 0.739 rs1014554 chr1:175133626 A/G cg17845761 chr1:175162550 KIAA0040 0.3 6.41 0.33 5.02e-10 Diastolic blood pressure; CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg22944662 chr1:178062847 LOC100302401;RASAL2 0.34 6.16 0.32 2.08e-9 Obesity-related traits; CRC trans rs2294025 0.833 rs4736434 chr8:134121121 C/T cg19857114 chr3:176741225 TBL1XR1 -0.38 -6.06 -0.32 3.68e-9 Graves' disease; CRC cis rs2806561 0.754 rs648322 chr1:23294839 C/T cg19743168 chr1:23544995 NA 0.35 5.62 0.3 4.17e-8 Height; CRC cis rs9911578 0.967 rs8072712 chr17:57162464 A/T cg05425664 chr17:57184151 TRIM37 -0.51 -8.07 -0.41 1.37e-14 Intelligence (multi-trait analysis); CRC cis rs853679 0.517 rs9393885 chr6:28050009 A/T cg12273811 chr6:28175739 NA 0.71 9.2 0.45 4.28e-18 Depression; CRC cis rs9858542 1.000 rs11130213 chr3:49712297 C/T cg00383909 chr3:49044727 WDR6 0.46 5.63 0.3 3.86e-8 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg17377491 chr11:112096999 PTS 0.47 6.64 0.34 1.32e-10 Response to antipsychotic treatment; CRC cis rs13108904 0.518 rs4974602 chr4:1342391 C/T cg24560729 chr4:1342394 KIAA1530 0.41 6.78 0.35 5.57e-11 Obesity-related traits; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg23629415 chr14:54955474 GMFB 0.41 6.04 0.32 4.06e-9 Intelligence (multi-trait analysis); CRC cis rs12618769 0.652 rs3754877 chr2:99184019 A/G cg18455616 chr2:99124870 INPP4A 0.36 5.83 0.31 1.31e-8 Bipolar disorder; CRC cis rs56114371 0.530 rs169262 chr6:27770890 C/T cg15845792 chr6:28175446 NA 0.51 5.92 0.31 8.03e-9 Breast cancer; CRC cis rs763014 0.966 rs15564 chr16:677854 G/T cg00802000 chr16:706648 WDR90 -0.43 -6.31 -0.33 9.1e-10 Height; CRC cis rs12534701 1.000 rs13232266 chr7:154681363 A/T cg24255201 chr7:154684926 DPP6 0.58 8.38 0.42 1.53e-15 Colorectal cancer (diet interaction); CRC cis rs2153535 0.601 rs330105 chr6:8543981 A/C cg07606381 chr6:8435919 SLC35B3 0.68 11.11 0.52 1.48e-24 Motion sickness; CRC cis rs2153535 0.542 rs6912740 chr6:8439959 A/G cg21535247 chr6:8435926 SLC35B3 0.48 7.24 0.37 3.19e-12 Motion sickness; CRC cis rs5769765 0.955 rs9616368 chr22:50303533 C/G cg02269571 chr22:50332266 NA -0.56 -7.53 -0.38 4.95e-13 Schizophrenia; CRC cis rs7773004 0.905 rs3778279 chr6:26325463 T/C cg13736514 chr6:26305472 NA -0.36 -6.17 -0.32 1.99e-9 Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for body mass index;Waist circumference adjusted for BMI in non-smokers;Waist circumference adjusted for BMI (adjusted for smoking behaviour); CRC cis rs763121 0.785 rs6001203 chr22:39099602 T/C cg06022373 chr22:39101656 GTPBP1 0.82 13.49 0.6 2.5e-33 Menopause (age at onset); CRC cis rs9479482 0.967 rs13209192 chr6:150350099 A/G cg25797454 chr6:150327115 RAET1K 0.36 6.22 0.32 1.49e-9 Alopecia areata; CRC cis rs4665809 0.887 rs6546716 chr2:26263836 A/G cg26119090 chr2:26468346 HADHA;HADHB -0.62 -7.95 -0.4 2.96e-14 Gut microbiome composition (summer); CRC cis rs6933660 0.646 rs9397051 chr6:151778325 C/T cg02564969 chr6:151773285 C6orf211;RMND1 0.43 6.15 0.32 2.25e-9 Menarche (age at onset); CRC cis rs4654899 0.772 rs12145203 chr1:21086127 C/T cg02927042 chr1:21476669 EIF4G3 -0.47 -7.22 -0.37 3.74e-12 Superior frontal gyrus grey matter volume; CRC cis rs8058578 0.943 rs7197770 chr16:30715908 T/C cg02466173 chr16:30829666 NA -0.67 -9.87 -0.48 2.79e-20 Multiple myeloma; CRC cis rs881375 0.967 rs10733648 chr9:123700779 A/G cg00246817 chr9:123691163 NA -0.46 -5.86 -0.31 1.13e-8 Rheumatoid arthritis; CRC trans rs10242455 1.000 rs17161692 chr7:98953863 A/G cg09045935 chr12:6379348 NA -0.71 -7.09 -0.36 8.04e-12 Blood metabolite levels; CRC cis rs875971 0.522 rs34973832 chr7:65396204 A/G cg18912574 chr7:65842487 NCRNA00174 0.33 5.62 0.3 4.06e-8 Aortic root size; CRC cis rs6951245 1.000 rs79422648 chr7:1080241 T/C cg04025307 chr7:1156635 C7orf50 0.64 6.76 0.35 6.29e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs2806561 0.704 rs2868573 chr1:23508253 C/G cg12483005 chr1:23474871 LUZP1 0.5 7.27 0.37 2.58e-12 Height; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg20566942 chr11:28129866 METT5D1;KIF18A 0.39 6.14 0.32 2.35e-9 Intelligence (multi-trait analysis); CRC cis rs10927875 0.722 rs1763606 chr1:16338282 A/G cg22431228 chr1:16359049 CLCNKA -0.43 -7.55 -0.38 4.24e-13 Dilated cardiomyopathy; CRC cis rs3858526 0.916 rs11039551 chr11:5930773 C/T cg05234568 chr11:5960015 NA -0.56 -7.76 -0.39 1.1e-13 DNA methylation (variation); CRC trans rs4955793 0.585 rs61796591 chr3:178648302 T/G cg11644478 chr21:40555479 PSMG1 0.66 6.06 0.32 3.69e-9 Post-traumatic stress disorder (asjusted for relatedness); CRC cis rs7666738 0.830 rs13138920 chr4:99020786 A/G cg17366294 chr4:99064904 C4orf37 0.43 7.29 0.37 2.28e-12 Colonoscopy-negative controls vs population controls; CRC cis rs8072100 0.837 rs62074055 chr17:45771933 G/C cg08085267 chr17:45401833 C17orf57 -0.57 -8.53 -0.43 5.27e-16 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs7666738 0.830 rs28878289 chr4:98855181 C/T cg17366294 chr4:99064904 C4orf37 0.41 6.67 0.35 1.08e-10 Colonoscopy-negative controls vs population controls; CRC cis rs11690935 0.632 rs62184165 chr2:172558328 A/G cg13550731 chr2:172543902 DYNC1I2 0.69 10.49 0.5 2.16e-22 Schizophrenia; CRC cis rs11148252 0.595 rs4885117 chr13:53153027 T/C cg12458913 chr13:53173898 NA 0.76 14.23 0.62 3.93e-36 Lewy body disease; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg07067521 chr19:41196729 NUMBL 0.46 6.53 0.34 2.48e-10 Response to antipsychotic treatment; CRC cis rs2836974 0.568 rs8130795 chr21:40549983 T/A cg22974920 chr21:40686053 BRWD1 0.45 6.13 0.32 2.48e-9 Cognitive function; CRC cis rs3806843 0.838 rs2262567 chr5:140132134 T/A cg19875535 chr5:140030758 IK -0.53 -8.41 -0.42 1.22e-15 Depressive symptoms (multi-trait analysis); CRC cis rs10504229 1.000 rs66495524 chr8:58187365 C/T cg24829409 chr8:58192753 C8orf71 -0.68 -11.34 -0.53 2.27e-25 Developmental language disorder (linguistic errors); CRC cis rs9916302 0.555 rs12940193 chr17:37652178 T/G cg07936489 chr17:37558343 FBXL20 -0.78 -11.79 -0.54 5.4e-27 Glomerular filtration rate (creatinine); CRC cis rs7731657 0.537 rs17621442 chr5:130205555 T/C cg08523029 chr5:130500466 HINT1 -0.49 -6.03 -0.32 4.4e-9 Fasting plasma glucose; CRC cis rs3796352 1.000 rs71299622 chr3:52917038 G/A cg06204229 chr3:52865917 ITIH4 0.52 5.85 0.31 1.19e-8 Immune reponse to smallpox (secreted IL-2); CRC cis rs7712401 0.686 rs154511 chr5:122195554 T/A cg18764291 chr5:122110994 SNX2 0.36 5.73 0.3 2.23e-8 Mean platelet volume; CRC cis rs6545883 0.507 rs12478192 chr2:61591175 A/G cg10580144 chr2:61372316 C2orf74 -0.35 -7.89 -0.4 4.41e-14 Tuberculosis; CRC cis rs4409675 0.576 rs6564 chr1:28212975 A/G cg23691781 chr1:28212827 C1orf38 -0.34 -7.95 -0.4 3.12e-14 Corneal astigmatism; CRC cis rs10876993 1.000 rs10876993 chr12:58062667 C/T cg18357645 chr12:58087776 OS9 0.58 8.25 0.41 3.76e-15 Celiac disease or Rheumatoid arthritis; CRC cis rs4713118 0.621 rs9295755 chr6:28033174 C/T cg15786705 chr6:28176104 NA -0.69 -9.04 -0.45 1.4e-17 Parkinson's disease; CRC cis rs12497850 0.865 rs13072911 chr3:48962128 T/G cg20833759 chr3:49053208 WDR6;DALRD3 0.51 8.8 0.44 8.02e-17 Parkinson's disease; CRC cis rs6500395 0.775 rs7191225 chr16:48662675 C/G cg04672837 chr16:48644449 N4BP1 0.41 6.16 0.32 2.09e-9 Response to tocilizumab in rheumatoid arthritis; CRC cis rs7552404 0.889 rs2211080 chr1:76243438 G/A cg22875332 chr1:76189707 ACADM 0.7 9.47 0.46 5.71e-19 Blood metabolite levels;Acylcarnitine levels; CRC cis rs11690935 0.589 rs62183782 chr2:172865009 T/A cg13550731 chr2:172543902 DYNC1I2 0.63 9.1 0.45 8.84e-18 Schizophrenia; CRC cis rs7647973 0.925 rs6446256 chr3:49224210 A/G cg07636037 chr3:49044803 WDR6 0.64 7.9 0.4 4.09e-14 Menarche (age at onset); CRC trans rs9929218 0.551 rs6499193 chr16:68727069 C/T cg04657470 chr2:198365150 HSPE1;HSPD1 1.04 21.56 0.77 6.84e-65 Colorectal cancer; CRC cis rs7107174 1.000 rs10793309 chr11:78093799 G/A cg02023728 chr11:77925099 USP35 0.46 7.77 0.39 1.03e-13 Testicular germ cell tumor; CRC cis rs17376456 0.877 rs12716457 chr5:93397627 T/C cg21475434 chr5:93447410 FAM172A 0.74 7.56 0.38 4.17e-13 Diabetic retinopathy; CRC cis rs1799949 0.965 rs11650132 chr17:41326087 T/G cg19454999 chr17:41278357 BRCA1;NBR2 0.54 8.34 0.42 2.09e-15 Menopause (age at onset); CRC cis rs78456975 1.000 rs13416881 chr2:1554808 G/A cg26248373 chr2:1572462 NA -0.66 -7.1 -0.36 7.65e-12 Placebo response in major depressive disorder (% change in symptom score); CRC cis rs16937 0.662 rs11588199 chr1:205164580 C/T cg00857998 chr1:205179979 DSTYK 0.41 5.65 0.3 3.49e-8 Schizophrenia; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg10706266 chr8:66546233 ARMC1 0.5 7.21 0.37 3.93e-12 Response to antipsychotic treatment; CRC cis rs7666738 0.830 rs9999200 chr4:99030690 A/C cg17366294 chr4:99064904 C4orf37 0.44 7.48 0.38 6.96e-13 Colonoscopy-negative controls vs population controls; CRC cis rs2836974 0.831 rs2836964 chr21:40631006 T/C cg11890956 chr21:40555474 PSMG1 1.11 19.18 0.73 1.39e-55 Cognitive function; CRC cis rs9443645 0.901 rs1027813 chr6:79552118 G/T cg09184832 chr6:79620586 NA 0.49 9.28 0.46 2.29e-18 Intelligence (multi-trait analysis); CRC cis rs9463078 0.605 rs3799981 chr6:44882380 T/A cg25276700 chr6:44698697 NA 0.25 6.04 0.32 4.21e-9 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; CRC cis rs9969804 0.837 rs6479424 chr9:95297077 A/G cg14631576 chr9:95140430 CENPP -0.32 -5.88 -0.31 1.03e-8 Height; CRC cis rs875971 0.964 rs55748098 chr7:65763618 T/C cg18876405 chr7:65276391 NA -0.52 -8.9 -0.44 3.92e-17 Aortic root size; CRC cis rs853679 0.517 rs4713152 chr6:28137454 G/A cg15786705 chr6:28176104 NA 0.78 9.83 0.48 3.57e-20 Depression; CRC cis rs4363385 0.567 rs7551791 chr1:153024267 A/T cg25856811 chr1:152973957 SPRR3 -0.23 -6.16 -0.32 2.09e-9 Inflammatory skin disease; CRC cis rs2228479 0.850 rs11645240 chr16:89837326 T/C cg06656553 chr16:89960601 TCF25 -0.7 -5.97 -0.31 6.14e-9 Skin colour saturation; CRC cis rs9807989 0.801 rs4851566 chr2:102972799 G/C cg03938978 chr2:103052716 IL18RAP 0.36 5.89 0.31 9.54e-9 Asthma; CRC trans rs1005277 0.505 rs200935 chr10:38132810 T/A cg17830980 chr10:43048298 ZNF37B -0.4 -6.3 -0.33 9.66e-10 Extrinsic epigenetic age acceleration; CRC cis rs10229583 0.527 rs7778413 chr7:127357716 T/C cg01233922 chr7:127693937 SND1 -0.49 -7.49 -0.38 6.23e-13 Type 2 diabetes; CRC cis rs79349575 0.811 rs12601072 chr17:46997998 T/C cg00947319 chr17:47005597 UBE2Z -0.34 -5.87 -0.31 1.06e-8 Type 2 diabetes; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg05645997 chr2:108443466 LOC729121;RGPD4 -0.39 -6.71 -0.35 8.51e-11 Liver disease severity in Alagille syndrome; CRC cis rs2075371 0.611 rs12707154 chr7:134015832 C/T cg20476274 chr7:133979776 SLC35B4 0.56 8.07 0.41 1.35e-14 Mean platelet volume; CRC cis rs11229555 1.000 rs11229545 chr11:58386650 A/G cg15696309 chr11:58395628 NA -0.95 -13.35 -0.59 8.41e-33 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg06779604 chr7:122526572 CADPS2 0.4 6.49 0.34 3.24e-10 Liver disease severity in Alagille syndrome; CRC cis rs11212617 1.000 rs645485 chr11:108168863 A/G cg01991180 chr11:108092276 ATM;NPAT 0.4 5.83 0.31 1.35e-8 Response to metformin in type 2 diabetes (glycemic); CRC cis rs372883 0.600 rs2832291 chr21:30734388 C/T cg08807101 chr21:30365312 RNF160 0.52 7.27 0.37 2.59e-12 Pancreatic cancer; CRC cis rs10504229 0.683 rs55986917 chr8:58137210 C/T cg22535103 chr8:58192502 C8orf71 -0.7 -9.34 -0.46 1.47e-18 Developmental language disorder (linguistic errors); CRC cis rs883565 0.655 rs7619193 chr3:39044116 T/C cg01426195 chr3:39028469 NA -0.54 -8.69 -0.43 1.7e-16 Handedness; CRC cis rs3858526 0.523 rs10769290 chr11:5886947 T/A cg13902645 chr11:5959945 NA -0.67 -9.98 -0.48 1.16e-20 DNA methylation (variation); CRC cis rs427941 0.668 rs201459 chr7:101741502 G/A cg06246474 chr7:101738831 CUX1 0.46 7.24 0.37 3.2e-12 Plasma omega-3 polyunsaturated fatty acid level (eicosapentaenoic acid); CRC cis rs1799949 0.965 rs1842147 chr17:41435192 C/T cg01879757 chr17:41196368 BRCA1 -0.41 -5.98 -0.31 5.75e-9 Menopause (age at onset); CRC cis rs2289328 0.882 rs7164581 chr15:40645098 C/G cg13931752 chr15:40660718 DISP2 -0.55 -6.56 -0.34 2.14e-10 Intelligence (multi-trait analysis);Cognitive ability;Cognitive ability (multi-trait analysis); CRC cis rs7527798 0.592 rs11118337 chr1:207852693 G/C cg09232269 chr1:207846808 CR1L -0.48 -7.79 -0.39 8.9e-14 Erythrocyte sedimentation rate; CRC cis rs801193 0.660 rs2659914 chr7:66156914 C/T cg12463550 chr7:65579703 CRCP 0.47 6.54 0.34 2.3e-10 Aortic root size; CRC cis rs1448094 0.511 rs11117023 chr12:86145329 G/A cg25456477 chr12:86230367 RASSF9 -0.36 -6.07 -0.32 3.43e-9 Major depressive disorder; CRC cis rs9814567 1.000 rs9828815 chr3:134265749 C/T cg06109529 chr3:134205091 CEP63;ANAPC13 -0.81 -12.19 -0.56 1.92e-28 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs514406 0.708 rs480299 chr1:53320274 G/T cg27535305 chr1:53392650 SCP2 -0.45 -8.11 -0.41 1.04e-14 Monocyte count; CRC cis rs3820068 0.581 rs1547031 chr1:15918960 G/A cg27534772 chr1:16042836 PLEKHM2 0.55 10.53 0.5 1.54e-22 Systolic blood pressure; CRC cis rs73206853 0.563 rs7968913 chr12:111138558 C/T cg12870014 chr12:110450643 ANKRD13A 0.65 6.05 0.32 3.96e-9 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC cis rs7618501 0.665 rs7621352 chr3:50070763 A/C cg24308560 chr3:49941425 MST1R 0.51 8.24 0.41 4.21e-15 Intelligence (multi-trait analysis); CRC cis rs72627123 0.867 rs17093884 chr14:74482039 A/G cg12022184 chr14:74485813 ENTPD5;C14orf45 0.72 6.19 0.32 1.8e-9 Morning vs. evening chronotype; CRC trans rs2832077 0.527 rs2142375 chr21:30223742 G/A cg14791747 chr16:20752902 THUMPD1 0.67 10.89 0.51 8.36e-24 Cognitive test performance; CRC cis rs9325144 0.555 rs1813392 chr12:38692203 C/T cg26384229 chr12:38710491 ALG10B -0.48 -7.27 -0.37 2.56e-12 Morning vs. evening chronotype; CRC trans rs2243480 1.000 rs7804223 chr7:65664559 T/G cg10756647 chr7:56101905 PSPH -0.78 -7.93 -0.4 3.35e-14 Diabetic kidney disease; CRC cis rs798554 0.757 rs2533882 chr7:2846894 G/T cg14895029 chr7:2775587 GNA12 -0.45 -6.52 -0.34 2.67e-10 Height; CRC cis rs9916302 0.904 rs10221223 chr17:37489100 T/G cg07936489 chr17:37558343 FBXL20 0.83 12.6 0.57 5.51e-30 Glomerular filtration rate (creatinine); CRC cis rs2404602 0.583 rs4381566 chr15:76589262 A/G cg23625390 chr15:77176239 SCAPER 0.39 5.67 0.3 3.08e-8 Blood metabolite levels; CRC cis rs4713118 0.662 rs149947 chr6:27972433 A/T cg12273811 chr6:28175739 NA 0.63 8.87 0.44 4.79e-17 Parkinson's disease; CRC cis rs11122272 0.735 rs973253 chr1:231520874 C/T cg06096015 chr1:231504339 EGLN1 0.4 5.98 0.31 5.78e-9 Hemoglobin concentration; CRC trans rs453301 0.658 rs6986044 chr8:8874786 G/C cg16141378 chr3:129829833 LOC729375 0.41 6.02 0.31 4.76e-9 Joint mobility (Beighton score); CRC cis rs6088590 0.735 rs6060003 chr20:33294945 T/C cg08999081 chr20:33150536 PIGU 0.54 9.48 0.46 5.06e-19 Coronary artery disease; CRC cis rs1577917 0.958 rs7382798 chr6:86559834 C/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.51 -6.59 -0.34 1.76e-10 Response to antipsychotic treatment; CRC cis rs9847710 0.967 rs2564934 chr3:53024580 G/A cg04503182 chr3:53078218 SFMBT1 0.41 6.19 0.32 1.75e-9 Ulcerative colitis; CRC cis rs6121246 0.909 rs6060679 chr20:30270772 C/G cg13852791 chr20:30311386 BCL2L1 -0.69 -10.7 -0.51 4.05e-23 Mean corpuscular hemoglobin; CRC cis rs612683 0.664 rs6702766 chr1:100997635 A/G cg06223162 chr1:101003688 GPR88 -0.39 -7.06 -0.36 1.01e-11 Breast cancer; CRC cis rs11148252 0.532 rs9536190 chr13:53181044 T/C cg12458913 chr13:53173898 NA 0.92 16.64 0.68 1.57e-45 Lewy body disease; CRC cis rs4689388 0.853 rs13108780 chr4:6294630 A/G cg14416269 chr4:6271139 WFS1 0.4 6.59 0.34 1.72e-10 Type 2 diabetes and other traits;Type 2 diabetes; CRC cis rs736408 0.648 rs3774355 chr3:52817778 G/A cg18404041 chr3:52824283 ITIH1 -0.45 -8.87 -0.44 4.84e-17 Bipolar disorder; CRC cis rs56104184 0.723 rs73063515 chr19:49407715 C/T cg15549821 chr19:49342101 PLEKHA4 -0.53 -5.98 -0.31 5.86e-9 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; CRC cis rs2180341 1.000 rs9398837 chr6:127635217 G/A cg24812749 chr6:127587940 RNF146 0.95 13.75 0.6 2.59e-34 Breast cancer; CRC cis rs4132509 0.793 rs4478795 chr1:243844576 C/T cg21452805 chr1:244014465 NA 0.59 7.41 0.38 1.09e-12 RR interval (heart rate); CRC cis rs17401966 0.540 rs7546368 chr1:10418826 G/A cg19773385 chr1:10388646 KIF1B -0.47 -7.44 -0.38 8.59e-13 Hepatocellular carcinoma; CRC cis rs4713118 0.662 rs149901 chr6:27965503 C/T cg25164649 chr6:28176230 NA 0.62 8.82 0.44 6.67e-17 Parkinson's disease; CRC cis rs977987 0.815 rs11646677 chr16:75408981 T/C cg03315344 chr16:75512273 CHST6 0.5 8.55 0.43 4.83e-16 Dupuytren's disease; CRC cis rs6752107 0.967 rs3792109 chr2:234184417 G/A cg07618928 chr2:234183455 ATG16L1;SCARNA5 0.64 10.89 0.51 8.38e-24 Crohn's disease;Inflammatory bowel disease; CRC cis rs4713118 0.662 rs9380045 chr6:28025279 A/G cg12172441 chr6:28176163 NA 0.55 6.96 0.36 1.83e-11 Parkinson's disease; CRC cis rs7605827 0.930 rs1852751 chr2:15557320 C/T cg19274914 chr2:15703543 NA 0.39 5.91 0.31 8.33e-9 Educational attainment (years of education); CRC cis rs9905704 0.918 rs11655808 chr17:56854517 T/C cg12560992 chr17:57184187 TRIM37 0.54 7.38 0.38 1.33e-12 Testicular germ cell tumor; CRC cis rs11098499 0.865 rs28634456 chr4:120375778 A/G cg09307838 chr4:120376055 NA 0.73 11.0 0.52 3.52e-24 Corneal astigmatism; CRC cis rs2404602 0.692 rs10444858 chr15:76962504 T/C cg22467129 chr15:76604101 ETFA -0.39 -6.54 -0.34 2.4e-10 Blood metabolite levels; CRC cis rs12594515 0.591 rs35554150 chr15:45990298 G/A cg06207120 chr15:45996521 NA 0.31 6.19 0.32 1.83e-9 Waist circumference;Weight; CRC cis rs1552244 0.554 rs55847233 chr3:9991101 C/G cg08888203 chr3:10149979 C3orf24 0.45 7.19 0.37 4.45e-12 Alzheimer's disease; CRC cis rs4665809 0.878 rs35709953 chr2:26334997 G/A cg04944784 chr2:26401820 FAM59B 0.68 7.79 0.39 8.9e-14 Gut microbiome composition (summer); CRC cis rs11690935 0.731 rs10930491 chr2:172569824 A/G cg13550731 chr2:172543902 DYNC1I2 0.69 10.46 0.5 2.68e-22 Schizophrenia; CRC cis rs2075371 0.966 rs1646646 chr7:133996905 G/T cg20476274 chr7:133979776 SLC35B4 0.81 14.6 0.63 1.43e-37 Mean platelet volume; CRC cis rs7615952 0.599 rs12496921 chr3:125701948 C/G cg15145296 chr3:125709740 NA -0.57 -6.72 -0.35 7.95e-11 Blood pressure (smoking interaction); CRC cis rs780096 0.565 rs10169261 chr2:27727314 C/T cg17158414 chr2:27665306 KRTCAP3 -0.29 -6.17 -0.32 2e-9 Total body bone mineral density; CRC cis rs3785574 0.962 rs4480868 chr17:61788859 C/T cg06873352 chr17:61820015 STRADA 0.51 8.38 0.42 1.6e-15 Height; CRC cis rs4481887 1.000 rs4430369 chr1:248464330 A/G cg13385794 chr1:248469461 NA 0.38 6.63 0.34 1.36e-10 Common traits (Other); CRC cis rs8180040 0.726 rs1463393 chr3:46994987 G/A cg02527881 chr3:46936655 PTH1R 0.41 7.48 0.38 6.71e-13 Colorectal cancer; CRC cis rs2836974 0.666 rs4818015 chr21:40675493 A/C cg11644478 chr21:40555479 PSMG1 0.68 10.96 0.52 5.0600000000000004e-24 Cognitive function; CRC cis rs870825 0.616 rs2130394 chr4:185642577 C/A cg04058563 chr4:185651563 MLF1IP 0.72 9.42 0.46 8.15e-19 Blood protein levels; CRC cis rs11690935 0.632 rs34242651 chr2:172553999 G/A cg13550731 chr2:172543902 DYNC1I2 0.69 10.32 0.49 7.93e-22 Schizophrenia; CRC cis rs55794721 0.509 rs11249248 chr1:25753051 T/C cg20684491 chr1:25596433 NA 0.41 7.27 0.37 2.6e-12 Plateletcrit;Mean corpuscular volume; CRC cis rs11105298 0.891 rs12369195 chr12:89934972 G/C cg00757033 chr12:89920650 WDR51B 0.38 6.18 0.32 1.91e-9 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; CRC cis rs4689388 0.926 rs9998519 chr4:6292909 C/T cg00701064 chr4:6280414 WFS1 0.75 12.9 0.58 4.34e-31 Type 2 diabetes and other traits;Type 2 diabetes; CRC cis rs11122272 0.668 rs1538664 chr1:231555295 C/T cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.58 -9.06 -0.45 1.2e-17 Hemoglobin concentration; CRC cis rs34779708 0.931 rs13376801 chr10:35370443 T/C cg03585969 chr10:35415529 CREM 0.57 7.61 0.39 2.94e-13 Inflammatory bowel disease;Crohn's disease; CRC cis rs1552244 1.000 rs13319597 chr3:10126312 A/C cg02579736 chr3:10068473 FANCD2;CIDECP -0.97 -13.1 -0.59 7.64e-32 Alzheimer's disease; CRC cis rs6461049 0.800 rs3800913 chr7:2163237 A/G cg04267008 chr7:1944627 MAD1L1 -0.52 -7.3 -0.37 2.24e-12 Schizophrenia; CRC cis rs6912958 0.781 rs3934838 chr6:88284699 T/C cg12350822 chr6:88032061 C6orf162;GJB7 -0.34 -6.37 -0.33 6.44e-10 Monocyte percentage of white cells; CRC cis rs5769707 0.592 rs6009783 chr22:50011001 C/G cg20744362 chr22:50050164 C22orf34 0.34 6.2 0.32 1.69e-9 Monocyte count;Monocyte percentage of white cells; CRC cis rs9733 0.596 rs2867304 chr1:150630995 G/A cg15448220 chr1:150897856 SETDB1 0.45 6.43 0.33 4.42e-10 Tonsillectomy; CRC cis rs6738485 0.557 rs12988865 chr2:106854386 G/A cg16099169 chr2:106886729 NA -0.35 -5.98 -0.31 5.73e-9 Pursuit maintenance gain;Pursuit maintenance gain in psychotic disorders; CRC trans rs2727020 0.656 rs7925524 chr11:49437542 G/A cg03929089 chr4:120376271 NA -0.78 -11.01 -0.52 3.34e-24 Coronary artery disease; CRC cis rs12188164 0.965 rs11745789 chr5:450777 T/C cg15813090 chr5:442598 EXOC3;C5orf55 0.39 5.63 0.3 3.9e-8 Cystic fibrosis severity; CRC cis rs877282 1.000 rs71494928 chr10:769134 A/G cg17470449 chr10:769945 NA 0.67 8.94 0.44 2.86e-17 Uric acid levels; CRC cis rs1707322 1.000 rs6657720 chr1:46386269 G/A cg03146154 chr1:46216737 IPP 0.5 7.04 0.36 1.12e-11 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC trans rs9329221 0.868 rs7831557 chr8:10280228 C/T cg14979609 chr8:8086686 FLJ10661 0.37 5.99 0.31 5.42e-9 Neuroticism; CRC cis rs13256369 0.755 rs12680167 chr8:8562467 A/G cg00074818 chr8:8560427 CLDN23 0.39 7.09 0.36 8.1e-12 Obesity-related traits; CRC cis rs6901250 0.819 rs9374623 chr6:117127312 C/A cg12892004 chr6:117198278 RFX6 0.45 7.02 0.36 1.27e-11 C-reactive protein levels; CRC cis rs2386661 0.516 rs61832676 chr10:5646337 G/A cg26603656 chr10:5671107 NA 0.45 7.55 0.38 4.39e-13 Breast cancer; CRC cis rs875971 0.862 rs10250544 chr7:65766561 A/G cg00343986 chr7:65444356 GUSB -0.45 -6.27 -0.33 1.12e-9 Aortic root size; CRC cis rs7493 0.755 rs740264 chr7:95021803 T/G cg21856205 chr7:94953877 PON1 -0.46 -5.81 -0.31 1.48e-8 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs1153858 1.000 rs7167900 chr15:45639471 A/G cg21132104 chr15:45694354 SPATA5L1 0.58 8.61 0.43 3.09e-16 Homoarginine levels; CRC cis rs9467603 0.858 rs1937126 chr6:25769608 G/C cg08501292 chr6:25962987 TRIM38 -0.67 -6.29 -0.33 1.01e-9 Intelligence (multi-trait analysis); CRC cis rs7659604 0.676 rs6855269 chr4:122697418 T/G cg06713675 chr4:122721982 EXOSC9 -0.53 -8.68 -0.43 1.86e-16 Type 2 diabetes; CRC cis rs4891159 0.660 rs4891160 chr18:74102135 C/T cg24786174 chr18:74118243 ZNF516 0.7 12.37 0.56 3.99e-29 Longevity; CRC cis rs3857536 0.813 rs2188589 chr6:66939570 C/T cg07460842 chr6:66804631 NA -0.43 -5.81 -0.3 1.48e-8 Blood trace element (Cu levels); CRC cis rs2463822 0.614 rs117699706 chr11:62161659 T/C cg06239285 chr11:62104954 ASRGL1 -0.92 -9.42 -0.46 8.4e-19 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs780096 0.526 rs7594812 chr2:27611469 A/G cg12648201 chr2:27665141 KRTCAP3 -0.29 -5.75 -0.3 1.99e-8 Total body bone mineral density; CRC trans rs7267979 0.903 rs6115109 chr20:25239667 G/A cg17903999 chr18:56338584 MALT1 -0.41 -6.41 -0.33 5.12e-10 Liver enzyme levels (alkaline phosphatase); CRC cis rs11608355 0.508 rs12822899 chr12:109800978 A/G cg19025524 chr12:109796872 NA -0.47 -6.98 -0.36 1.6e-11 Neuroticism; CRC cis rs3771570 1.000 rs73018141 chr2:242221570 G/A cg21155796 chr2:242212141 HDLBP 0.64 7.0 0.36 1.48e-11 Prostate cancer; CRC cis rs7615952 0.641 rs60839048 chr3:125807938 G/A cg02772935 chr3:125709198 NA -0.5 -5.81 -0.3 1.5e-8 Blood pressure (smoking interaction); CRC cis rs6662572 1.000 rs7517111 chr1:46122140 A/G cg03123370 chr1:45965343 CCDC163P;MMACHC 0.49 5.86 0.31 1.12e-8 Blood protein levels; CRC cis rs2290159 0.800 rs7636754 chr3:12678725 C/G cg23032965 chr3:12705835 RAF1 0.47 6.38 0.33 6.16e-10 Cholesterol, total; CRC cis rs1005277 0.579 rs1985707 chr10:38434098 C/T cg00409905 chr10:38381863 ZNF37A -0.67 -11.17 -0.52 9.01e-25 Extrinsic epigenetic age acceleration; CRC cis rs11148252 0.967 rs11618716 chr13:53046836 A/G cg00495681 chr13:53174319 NA -0.59 -9.34 -0.46 1.49e-18 Lewy body disease; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg11688874 chr10:28822482 WAC 0.48 6.41 0.33 5.15e-10 Thyroid stimulating hormone; CRC cis rs7647973 1.000 rs3870339 chr3:49536863 T/A cg07690219 chr3:49449608 TCTA;RHOA -0.52 -6.03 -0.32 4.37e-9 Menarche (age at onset); CRC cis rs755249 0.567 rs41270799 chr1:39748662 G/A cg18385671 chr1:39797026 MACF1 -0.42 -5.85 -0.31 1.2e-8 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs1006703 0.544 rs10153291 chr17:3833740 G/A cg06463185 chr17:3833770 ATP2A3 -0.67 -7.29 -0.37 2.26e-12 Glucose homeostasis traits; CRC cis rs11792861 0.816 rs17792434 chr9:111667319 C/T cg05043794 chr9:111880884 C9orf5 -0.33 -5.91 -0.31 8.76e-9 Menarche (age at onset); CRC cis rs2153535 0.601 rs9502715 chr6:8455709 C/T cg07606381 chr6:8435919 SLC35B3 0.68 10.91 0.52 7.29e-24 Motion sickness; CRC cis rs9916302 0.904 rs12450559 chr17:37694709 G/A cg15445000 chr17:37608096 MED1 0.43 9.45 0.46 6.4e-19 Glomerular filtration rate (creatinine); CRC cis rs1448094 0.802 rs56391398 chr12:86424114 C/T cg02569458 chr12:86230093 RASSF9 0.48 8.13 0.41 8.91e-15 Major depressive disorder; CRC trans rs12599106 0.818 rs17723574 chr16:34602945 C/G cg11235426 chr6:292522 DUSP22 -0.54 -7.79 -0.39 8.74e-14 Menopause (age at onset); CRC trans rs7824557 0.527 rs2572446 chr8:11239565 C/T cg06636001 chr8:8085503 FLJ10661 -0.44 -6.47 -0.34 3.6e-10 Retinal vascular caliber; CRC trans rs4332037 0.538 rs4721164 chr7:1932629 C/G cg11693508 chr17:37793320 STARD3 0.55 7.41 0.38 1.08e-12 Bipolar disorder; CRC cis rs1865760 0.534 rs1541988 chr6:25950804 C/A cg12310025 chr6:25882481 NA -0.42 -6.38 -0.33 5.93e-10 Height; CRC cis rs9311676 0.656 rs7647078 chr3:58369912 C/T cg06643156 chr3:58380774 PXK 0.42 6.39 0.33 5.78e-10 Systemic lupus erythematosus; CRC cis rs951366 0.646 rs1772159 chr1:205759195 G/A cg07167872 chr1:205819463 PM20D1 0.95 15.69 0.65 8.13e-42 Menarche (age at onset); CRC cis rs1348850 0.918 rs12463893 chr2:178448559 G/T cg02961200 chr2:178257176 LOC100130691;AGPS 0.5 7.23 0.37 3.34e-12 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs933688 1.000 rs7720132 chr5:90745105 T/C cg02339078 chr5:90679543 LOC100129716;ARRDC3 0.88 13.58 0.6 1.14e-33 Smoking behavior; CRC cis rs1552244 1.000 rs6807846 chr3:10134491 G/T cg08888203 chr3:10149979 C3orf24 0.69 9.68 0.47 1.15e-19 Alzheimer's disease; CRC cis rs7208859 0.623 rs609063 chr17:28951513 A/G cg01831904 chr17:28903510 LRRC37B2 -0.59 -6.06 -0.32 3.74e-9 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs1788820 0.917 rs1788825 chr18:21109250 T/C cg14672496 chr18:21087552 C18orf8 0.55 9.74 0.47 7.5e-20 Body mass index; CRC cis rs1552244 1.000 rs7651058 chr3:10066964 C/T cg10729496 chr3:10149963 C3orf24 0.5 6.71 0.35 8.63e-11 Alzheimer's disease; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg04534726 chr3:23987467 NR1D2 0.47 6.72 0.35 8.1e-11 Anxiety disorder; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg06936779 chr1:151171405 PIP5K1A -0.45 -6.46 -0.34 3.71e-10 Myopia (pathological); CRC cis rs7618501 0.633 rs2008877 chr3:50162291 T/G cg24110177 chr3:50126178 RBM5 0.46 6.76 0.35 6.3e-11 Intelligence (multi-trait analysis); CRC cis rs1150688 1 rs1150688 chr6:28162780 T/C cg06470822 chr6:28175283 NA 0.67 10.27 0.49 1.2e-21 Autism spectrum disorder or schizophrenia; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg14293776 chr19:12371199 NA 0.44 6.67 0.35 1.05e-10 Liver disease severity in Alagille syndrome; CRC cis rs56307353 0.513 rs2041120 chr19:1961474 C/T cg05502645 chr19:1971281 CSNK1G2 0.51 7.96 0.4 2.82e-14 Coronary artery disease; CRC cis rs600806 0.815 rs10745356 chr1:109960270 C/A cg23032129 chr1:109941072 SORT1 -0.28 -5.94 -0.31 7.09e-9 Intelligence (multi-trait analysis); CRC cis rs1348850 0.632 rs11682717 chr2:178499240 C/G cg22681709 chr2:178499509 PDE11A -0.49 -9.12 -0.45 7.41e-18 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs929354 1.000 rs929354 chr7:157045557 C/T cg05182265 chr7:156933206 UBE3C 0.7 13.47 0.6 3.13e-33 Body mass index; CRC cis rs6460942 1.000 rs112794590 chr7:12319426 G/A cg20607287 chr7:12443886 VWDE -0.65 -6.43 -0.33 4.61e-10 Coronary artery disease; CRC cis rs12760731 0.920 rs10913562 chr1:178481750 A/C cg00404053 chr1:178313656 RASAL2 -0.69 -7.6 -0.39 3.17e-13 Obesity-related traits; CRC cis rs2252790 1.000 rs12203516 chr6:116638619 A/G cg18764771 chr6:116381957 FRK 0.22 5.75 0.3 2e-8 Fast beta electroencephalogram; CRC cis rs9733 0.628 rs11807409 chr1:150683423 C/T cg15448220 chr1:150897856 SETDB1 0.45 6.42 0.33 4.88e-10 Tonsillectomy; CRC cis rs1997103 0.911 rs9642575 chr7:55399090 C/T cg17469321 chr7:55412551 NA 0.74 11.44 0.53 9.4e-26 QRS interval (sulfonylurea treatment interaction); CRC cis rs2228479 0.717 rs2074904 chr16:89811546 A/G cg06558623 chr16:89946397 TCF25 1.15 10.8 0.51 1.85e-23 Skin colour saturation; CRC cis rs514406 0.505 rs387436 chr1:53179376 C/T cg08859206 chr1:53392774 SCP2 0.42 6.37 0.33 6.55e-10 Monocyte count; CRC cis rs11650494 0.710 rs74619404 chr17:47484445 C/T cg08112188 chr17:47440006 ZNF652 0.95 7.43 0.38 9.72e-13 Prostate cancer; CRC cis rs6586163 0.872 rs1800682 chr10:90749963 A/G cg03111039 chr10:90751583 FAS;ACTA2 -0.48 -6.86 -0.35 3.44e-11 Chronic lymphocytic leukemia; CRC cis rs453301 0.653 rs1045529 chr8:8890098 A/G cg06636001 chr8:8085503 FLJ10661 -0.52 -7.57 -0.39 3.86e-13 Joint mobility (Beighton score); CRC trans rs7819412 0.740 rs11250119 chr8:11037034 C/T cg06636001 chr8:8085503 FLJ10661 -0.44 -6.75 -0.35 6.77e-11 Triglycerides; CRC trans rs7937682 1.000 rs10502147 chr11:111569931 G/A cg18187862 chr3:45730750 SACM1L -0.53 -7.43 -0.38 9.67e-13 Primary sclerosing cholangitis; CRC cis rs477895 0.653 rs3824854 chr11:63885305 C/T cg05016508 chr11:63871570 FLRT1;MACROD1 0.53 6.71 0.35 8.69e-11 Mean platelet volume; CRC cis rs854765 0.929 rs854766 chr17:18012775 A/G cg09796270 chr17:17721594 SREBF1 0.46 7.62 0.39 2.75e-13 Total body bone mineral density; CRC cis rs7208859 0.623 rs9897728 chr17:29108804 A/G cg13385521 chr17:29058706 SUZ12P 0.73 8.4 0.42 1.39e-15 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg16786661 chr2:234160315 ATG16L1 0.37 6.09 0.32 3.12e-9 Obesity-related traits; CRC cis rs992157 0.730 rs4280446 chr2:219184721 T/C cg04880052 chr2:219191631 PNKD 0.4 6.1 0.32 3.01e-9 Colorectal cancer; CRC cis rs9393692 0.875 rs2142703 chr6:26289605 A/G cg00631329 chr6:26305371 NA -0.69 -13.6 -0.6 9.99e-34 Educational attainment; CRC cis rs4566357 0.615 rs2272204 chr2:227915601 G/T cg11843606 chr2:227700838 RHBDD1 -0.44 -6.82 -0.35 4.37e-11 Coronary artery disease; CRC cis rs9768139 0.733 rs56205111 chr7:158121055 T/C cg06219351 chr7:158114137 PTPRN2 -0.55 -8.29 -0.42 2.92e-15 Calcium levels; CRC cis rs9527 0.545 rs7915816 chr10:104881750 A/G cg04362960 chr10:104952993 NT5C2 0.6 8.31 0.42 2.6e-15 Arsenic metabolism; CRC cis rs875971 0.545 rs801212 chr7:66015630 C/G cg18876405 chr7:65276391 NA -0.44 -6.21 -0.32 1.57e-9 Aortic root size; CRC cis rs10504229 0.512 rs77289815 chr8:57995242 A/G cg08219700 chr8:58056026 NA 0.56 5.81 0.3 1.48e-8 Developmental language disorder (linguistic errors); CRC cis rs9682041 0.569 rs11914970 chr3:170112307 T/G cg11886554 chr3:170076028 SKIL 0.61 7.7 0.39 1.59e-13 Glomerular filtration rate in non diabetics (creatinine);Glomerular filtration rate (creatinine); CRC cis rs7428 1.000 rs7428 chr2:85545490 C/T cg24342717 chr2:85555507 TGOLN2 0.49 6.97 0.36 1.75e-11 Ear protrusion; CRC cis rs9549328 0.565 rs35988856 chr13:113617427 T/C cg20742385 chr13:113633654 MCF2L 0.56 9.5 0.46 4.54e-19 Systolic blood pressure; CRC cis rs4523957 0.890 rs11655813 chr17:2119101 C/T cg16513277 chr17:2031491 SMG6 -0.46 -7.44 -0.38 8.69e-13 Autism spectrum disorder or schizophrenia;Schizophrenia; CRC cis rs2153535 0.580 rs9379210 chr6:8461928 C/G cg07606381 chr6:8435919 SLC35B3 0.68 10.91 0.52 7.65e-24 Motion sickness; CRC cis rs72781680 0.581 rs116520786 chr2:24272645 C/T cg06627628 chr2:24431161 ITSN2 -0.54 -5.93 -0.31 7.68e-9 Lymphocyte counts; CRC cis rs11203032 0.831 rs11203022 chr10:90954068 G/A cg16672925 chr10:90967113 CH25H 0.45 5.74 0.3 2.17e-8 Heart failure; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg23084309 chr19:6280164 MLLT1 0.43 7.26 0.37 2.9e-12 Liver disease severity in Alagille syndrome; CRC cis rs9463078 0.625 rs6926370 chr6:44947280 G/C cg25276700 chr6:44698697 NA -0.25 -6.21 -0.32 1.56e-9 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; CRC cis rs17401966 0.540 rs6541094 chr1:10467074 G/A cg19773385 chr1:10388646 KIF1B -0.49 -7.76 -0.39 1.1e-13 Hepatocellular carcinoma; CRC cis rs3733585 0.604 rs73215003 chr4:10126317 C/G cg11266682 chr4:10021025 SLC2A9 -0.48 -9.04 -0.45 1.37e-17 Cleft plate (environmental tobacco smoke interaction); CRC cis rs7618501 0.633 rs13060128 chr3:50025028 A/G cg24110177 chr3:50126178 RBM5 -0.5 -7.88 -0.4 4.98e-14 Intelligence (multi-trait analysis); CRC cis rs2292864 0.764 rs3892085 chr17:45340480 A/G cg18085866 chr17:45331354 ITGB3 -0.61 -6.02 -0.31 4.73e-9 Left atrial antero-posterior diameter; CRC cis rs1008375 0.966 rs3796813 chr4:17591648 A/G cg16339924 chr4:17578868 LAP3 0.58 7.82 0.4 7.38e-14 Parasitemia in Tripanosoma cruzi seropositivity; CRC trans rs61931739 0.534 rs7313137 chr12:34010231 T/G cg26384229 chr12:38710491 ALG10B 0.54 6.9 0.36 2.76e-11 Morning vs. evening chronotype; CRC trans rs7395662 0.611 rs4882089 chr11:48515612 A/T cg15704280 chr7:45808275 SEPT13 -0.48 -6.86 -0.35 3.37e-11 HDL cholesterol; CRC cis rs929354 0.713 rs3802130 chr7:156965237 A/G cg05182265 chr7:156933206 UBE3C -0.76 -14.38 -0.62 1.04e-36 Body mass index; CRC cis rs4665809 0.556 rs1560869 chr2:26417095 T/C cg08067268 chr2:26466485 HADHB;HADHA -0.66 -8.45 -0.42 9.58e-16 Gut microbiome composition (summer); CRC cis rs7937682 0.883 rs566647 chr11:111466607 A/G cg09085632 chr11:111637200 PPP2R1B 0.96 17.46 0.69 9.05e-49 Primary sclerosing cholangitis; CRC cis rs12476592 0.516 rs7558796 chr2:63597108 T/A cg10828910 chr2:63850056 LOC388955 0.47 5.83 0.31 1.34e-8 Childhood ear infection; CRC cis rs1008375 0.932 rs11934968 chr4:17667766 A/G cg16339924 chr4:17578868 LAP3 0.5 6.17 0.32 2.02e-9 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs7914558 0.966 rs12571568 chr10:104891396 C/G cg15744005 chr10:104629667 AS3MT -0.34 -7.27 -0.37 2.57e-12 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs801193 0.569 rs2707847 chr7:66202871 C/G cg12463550 chr7:65579703 CRCP 0.45 6.12 0.32 2.72e-9 Aortic root size; CRC trans rs916888 0.610 rs199436 chr17:44789285 C/T cg07870213 chr5:140052090 DND1 -0.63 -8.23 -0.41 4.3e-15 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg24917945 chr10:120514927 C10orf46 0.46 6.08 0.32 3.4e-9 Thyroid stimulating hormone; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg25007351 chr3:160118866 SMC4 0.46 6.75 0.35 6.77e-11 Intelligence (multi-trait analysis); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg21482969 chr3:57261456 APPL1 0.43 6.2 0.32 1.69e-9 Response to antipsychotic treatment; CRC cis rs7726839 0.574 rs11134148 chr5:637107 C/T cg17948913 chr5:572064 NA 0.51 5.89 0.31 9.53e-9 Obesity-related traits; CRC cis rs6952808 0.792 rs12536261 chr7:1953571 G/A cg20295408 chr7:1910781 MAD1L1 -0.42 -5.96 -0.31 6.46e-9 Bipolar disorder and schizophrenia; CRC cis rs2737618 0.722 rs2737676 chr1:200086839 T/C cg21825944 chr1:200113062 NR5A2 -0.49 -6.95 -0.36 1.91e-11 Uric acid levels; CRC cis rs6674176 0.628 rs3791116 chr1:44414156 T/A cg13606994 chr1:44402422 ARTN -0.34 -5.69 -0.3 2.78e-8 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Cognitive ability; CRC cis rs870825 0.616 rs4519834 chr4:185633865 A/G cg04058563 chr4:185651563 MLF1IP -0.76 -9.55 -0.47 3.07e-19 Blood protein levels; CRC trans rs61931739 0.534 rs4931783 chr12:34115322 G/A cg26384229 chr12:38710491 ALG10B 0.53 6.87 0.35 3.15e-11 Morning vs. evening chronotype; CRC cis rs7772486 0.641 rs2253757 chr6:146199686 C/T cg23711669 chr6:146136114 FBXO30 0.65 9.52 0.46 3.76e-19 Lobe attachment (rater-scored or self-reported); CRC cis rs2354432 0.607 rs4950385 chr1:146656292 A/G cg25205988 chr1:146714368 CHD1L 1.14 9.22 0.45 3.66e-18 Mitochondrial DNA levels; CRC cis rs9858542 0.903 rs9875617 chr3:49634696 G/A cg07274523 chr3:49395745 GPX1 0.48 6.32 0.33 8.48e-10 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC trans rs1814175 0.817 rs10769617 chr11:49810421 G/A cg11707556 chr5:10655725 ANKRD33B -0.43 -8.04 -0.41 1.65e-14 Height; CRC cis rs67311347 1.000 rs1454497 chr3:40496326 C/T cg24209194 chr3:40518798 ZNF619 -0.44 -6.7 -0.35 8.91e-11 Renal cell carcinoma; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg22476645 chr16:15150025 NTAN1 0.43 5.98 0.31 5.97e-9 Response to antipsychotic treatment; CRC cis rs896854 0.846 rs7845219 chr8:95937502 T/C cg23172400 chr8:95962367 TP53INP1 -0.47 -7.66 -0.39 2.11e-13 Type 2 diabetes; CRC cis rs7072216 0.587 rs2296435 chr10:100182285 C/T cg26618903 chr10:100175079 PYROXD2 0.4 6.09 0.32 3.14e-9 Metabolite levels; CRC cis rs7773004 0.875 rs9393700 chr6:26309380 G/A cg13736514 chr6:26305472 NA -0.37 -6.22 -0.32 1.49e-9 Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for body mass index;Waist circumference adjusted for BMI in non-smokers;Waist circumference adjusted for BMI (adjusted for smoking behaviour); CRC cis rs561341 0.739 rs6505267 chr17:30225950 A/C cg00745463 chr17:30367425 LRRC37B -0.58 -7.43 -0.38 9.46e-13 Hip circumference adjusted for BMI; CRC cis rs7914558 1.000 rs7911789 chr10:104756374 T/C cg15744005 chr10:104629667 AS3MT -0.32 -6.87 -0.35 3.32e-11 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs7772486 0.534 rs34541797 chr6:146205304 A/G cg23711669 chr6:146136114 FBXO30 0.64 9.6 0.47 2.14e-19 Lobe attachment (rater-scored or self-reported); CRC trans rs7618501 0.633 rs55751738 chr3:49972101 A/G cg21665057 chr3:196295764 WDR53;FBXO45 0.56 8.93 0.44 3.16e-17 Intelligence (multi-trait analysis); CRC cis rs2739330 0.731 rs5751792 chr22:24401542 G/A cg16132339 chr22:24313637 DDTL;DDT 0.58 9.44 0.46 7.07e-19 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs67311347 0.911 rs9849224 chr3:40392562 T/C cg24209194 chr3:40518798 ZNF619 0.42 6.5 0.34 2.97e-10 Renal cell carcinoma; CRC cis rs3733585 0.806 rs11723382 chr4:9954660 T/C cg00071950 chr4:10020882 SLC2A9 -0.64 -11.98 -0.55 1.08e-27 Cleft plate (environmental tobacco smoke interaction); CRC cis rs7772486 0.624 rs6930154 chr6:146025662 C/T cg23711669 chr6:146136114 FBXO30 -0.67 -11.23 -0.53 5.29e-25 Lobe attachment (rater-scored or self-reported); CRC cis rs1448094 0.556 rs17345522 chr12:86169929 T/C cg18827107 chr12:86230957 RASSF9 -0.4 -6.12 -0.32 2.65e-9 Major depressive disorder; CRC cis rs7959452 0.535 rs11177577 chr12:69671791 C/T cg14784868 chr12:69753453 YEATS4 0.74 12.06 0.55 5.62e-28 Blood protein levels; CRC cis rs4363385 0.747 rs4240866 chr1:152954875 T/C cg25856811 chr1:152973957 SPRR3 -0.27 -7.45 -0.38 8.09e-13 Inflammatory skin disease; CRC cis rs7762018 0.556 rs80250989 chr6:170105553 T/C cg19338460 chr6:170058176 WDR27 -1.23 -11.18 -0.52 8.11e-25 Thiazide-induced adverse metabolic effects in hypertensive patients; CRC cis rs7647973 1.000 rs4241407 chr3:49600319 C/T cg07690219 chr3:49449608 TCTA;RHOA -0.53 -6.06 -0.32 3.74e-9 Menarche (age at onset); CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg22704915 chr10:73079101 SLC29A3 -0.4 -6.48 -0.34 3.43e-10 Myopia (pathological); CRC cis rs6424115 0.965 rs2502979 chr1:24149315 C/A cg09473613 chr1:24152604 HMGCL 0.36 6.12 0.32 2.59e-9 Immature fraction of reticulocytes; CRC cis rs12762955 0.608 rs7922760 chr10:1156815 G/C cg26597838 chr10:835615 NA -0.51 -7.08 -0.36 8.53e-12 Response to angiotensin II receptor blocker therapy; CRC cis rs12188164 1.000 rs34847072 chr5:437862 G/C cg17553881 chr5:443987 EXOC3;C5orf55 -0.36 -7.56 -0.38 4.07e-13 Cystic fibrosis severity; CRC cis rs11122272 0.735 rs2572253 chr1:231512768 C/A cg06096015 chr1:231504339 EGLN1 0.4 5.95 0.31 6.7e-9 Hemoglobin concentration; CRC cis rs1707322 1.000 rs4660905 chr1:46461587 C/T cg03146154 chr1:46216737 IPP -0.51 -7.13 -0.37 6.3e-12 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs9928842 0.824 rs12924999 chr16:75262425 T/G cg08657710 chr16:75258780 CTRB1 -0.57 -6.45 -0.34 3.9e-10 Alcoholic chronic pancreatitis; CRC cis rs11148252 0.538 rs2296349 chr13:52710058 T/G cg00495681 chr13:53174319 NA 0.62 9.4 0.46 9.79e-19 Lewy body disease; CRC trans rs66759488 0.739 rs10851451 chr15:47608991 A/G cg20918563 chr3:196263520 NA -0.47 -6.55 -0.34 2.16e-10 Lung cancer; CRC cis rs77633900 0.614 rs113557153 chr15:76994445 A/G cg21673338 chr15:77095150 SCAPER -0.78 -6.36 -0.33 6.56e-10 Non-glioblastoma glioma;Glioma; CRC trans rs9747201 0.926 rs8065606 chr17:80063526 G/A cg07393940 chr7:158741817 NA -0.52 -7.54 -0.38 4.67e-13 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs2243480 1.000 rs387676 chr7:65598220 C/T cg12463550 chr7:65579703 CRCP 0.69 6.4 0.33 5.42e-10 Diabetic kidney disease; CRC cis rs4819052 0.918 rs2330013 chr21:46658662 G/T cg02159808 chr21:46707872 POFUT2;LOC642852 0.62 7.57 0.39 3.8e-13 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs9462846 0.691 rs7744454 chr6:42914041 C/G cg05552183 chr6:42928497 GNMT 0.48 6.36 0.33 6.69e-10 Blood protein levels; CRC cis rs7115242 0.920 rs6589574 chr11:116730638 A/G cg26566898 chr11:117069891 TAGLN 0.5 5.79 0.3 1.68e-8 Age-related disease endophenotypes;Age-related diseases, mortality and associated endophenotypes; CRC cis rs2239547 0.563 rs4687560 chr3:52898121 T/G cg11645453 chr3:52864694 ITIH4 0.56 9.76 0.47 6.33e-20 Schizophrenia; CRC cis rs881375 0.900 rs1008383 chr9:123683579 C/G cg14255062 chr9:123606675 PSMD5;LOC253039 0.42 6.15 0.32 2.24e-9 Rheumatoid arthritis; CRC cis rs870825 0.860 rs2705899 chr4:185596219 A/G cg04058563 chr4:185651563 MLF1IP 0.55 5.92 0.31 7.93e-9 Blood protein levels; CRC cis rs17376456 1.000 rs67150649 chr5:93292377 A/G cg21475434 chr5:93447410 FAM172A 0.83 8.1 0.41 1.1e-14 Diabetic retinopathy; CRC cis rs861020 1.000 rs674433 chr1:209964875 A/C cg09163369 chr1:210001066 C1orf107 -0.52 -7.01 -0.36 1.34e-11 Orofacial clefts; CRC cis rs2832191 0.740 rs2832177 chr21:30478353 G/A cg08807101 chr21:30365312 RNF160 -0.71 -11.41 -0.53 1.2e-25 Dental caries; CRC cis rs875971 1.000 rs4718344 chr7:65874381 C/A cg18876405 chr7:65276391 NA 0.52 9.04 0.45 1.37e-17 Aortic root size; CRC cis rs12291225 0.585 rs11023197 chr11:14380998 G/A cg19336497 chr11:14380999 RRAS2 -0.52 -9.16 -0.45 5.53e-18 Sense of smell; CRC cis rs6691722 1.000 rs6691722 chr1:24673866 A/G cg18323236 chr1:24743029 NIPAL3 0.37 5.82 0.31 1.37e-8 Response to interferon beta in multiple sclerosis; CRC cis rs1552244 1.000 rs3826 chr3:10141065 T/G cg00166722 chr3:10149974 C3orf24 0.63 8.78 0.44 9.09e-17 Alzheimer's disease; CRC trans rs1455244 0.700 rs7229302 chr18:11508904 G/T cg06120528 chr15:78800245 AGPHD1 0.41 6.08 0.32 3.33e-9 Schizophrenia; CRC cis rs10046574 0.517 rs7782727 chr7:135200299 A/G cg27474649 chr7:135195673 CNOT4 0.67 6.29 0.33 9.88e-10 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs3790645 1.000 rs34062688 chr1:26887150 A/G cg23229016 chr1:26872525 RPS6KA1 0.3 7.29 0.37 2.39e-12 Glucose homeostasis traits; CRC cis rs12580194 0.593 rs12581916 chr12:55764409 A/C cg19537932 chr12:55886519 OR6C68 -0.72 -9.12 -0.45 7.84e-18 Cancer; CRC cis rs10504229 0.596 rs6991216 chr8:58115586 T/C cg21724239 chr8:58056113 NA 0.49 6.81 0.35 4.75e-11 Developmental language disorder (linguistic errors); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg26610681 chr1:87380186 HS2ST1;SEP15 0.39 6.12 0.32 2.69e-9 Liver disease severity in Alagille syndrome; CRC cis rs8177253 0.665 rs9869257 chr3:133451412 G/T cg24879335 chr3:133465180 TF 0.37 6.81 0.35 4.56e-11 Iron status biomarkers; CRC cis rs4588572 0.688 rs11743511 chr5:77692819 C/T cg11547950 chr5:77652471 NA -0.51 -7.63 -0.39 2.59e-13 Triglycerides; CRC cis rs3806843 0.868 rs2262574 chr5:140123635 G/T cg16607685 chr5:140181889 PCDHA2;PCDHA1;PCDHA3 0.25 6.0 0.31 5.08e-9 Depressive symptoms (multi-trait analysis); CRC cis rs1707322 0.638 rs1416706 chr1:46602844 G/A cg03146154 chr1:46216737 IPP -0.47 -6.06 -0.32 3.66e-9 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs9787249 0.957 rs2274949 chr1:40221067 G/A cg02773041 chr1:40204384 PPIE 0.62 9.25 0.45 2.97e-18 Blood protein levels; CRC cis rs7666738 0.830 rs6532720 chr4:99043781 C/T cg17366294 chr4:99064904 C4orf37 0.45 7.72 0.39 1.44e-13 Colonoscopy-negative controls vs population controls; CRC cis rs1552244 0.572 rs68121641 chr3:10165845 T/A cg00166722 chr3:10149974 C3orf24 0.65 7.7 0.39 1.56e-13 Alzheimer's disease; CRC cis rs17021463 0.676 rs17311887 chr4:95313228 T/C cg11021082 chr4:95130006 SMARCAD1 0.42 5.94 0.31 7.06e-9 Testicular germ cell tumor; CRC cis rs10193935 1.000 rs13421289 chr2:42412808 T/C cg27598129 chr2:42591480 NA -0.71 -8.3 -0.42 2.69e-15 Colonoscopy-negative controls vs population controls; CRC cis rs9611565 0.729 rs137831 chr22:41903813 A/C cg03806693 chr22:41940476 POLR3H -0.9 -12.65 -0.57 3.79e-30 Vitiligo; CRC cis rs6866344 0.570 rs1132338 chr5:178139442 T/G cg10224037 chr5:178157518 ZNF354A 0.75 11.01 0.52 3.3e-24 Neutrophil percentage of white cells; CRC cis rs1712517 0.844 rs1163075 chr10:105021263 A/G cg05636881 chr10:105038444 INA -0.47 -8.42 -0.42 1.19e-15 Migraine; CRC cis rs6912958 0.500 rs4707352 chr6:87929705 G/A cg04972856 chr6:88032051 C6orf162;GJB7 -0.34 -6.39 -0.33 5.53e-10 Monocyte percentage of white cells; CRC cis rs1395 0.710 rs11682913 chr2:27473649 G/A cg14242246 chr2:27434262 C2orf28;SLC5A6 0.42 7.53 0.38 5.05e-13 Blood metabolite levels; CRC cis rs2762353 0.595 rs12200838 chr6:25753603 C/T cg03264133 chr6:25882463 NA 0.72 10.02 0.48 8.33e-21 Blood metabolite levels; CRC trans rs2727020 0.612 rs603672 chr11:49234566 T/A cg11707556 chr5:10655725 ANKRD33B 0.38 7.05 0.36 1.09e-11 Coronary artery disease; CRC cis rs4243830 0.850 rs12046229 chr1:6580397 C/T cg22792644 chr1:6614718 TAS1R1;NOL9 0.71 5.95 0.31 6.99e-9 Body mass index; CRC cis rs7927771 0.524 rs11039431 chr11:47872012 G/T cg20307385 chr11:47447363 PSMC3 0.45 6.62 0.34 1.48e-10 Subjective well-being; CRC cis rs116095464 0.558 rs6872854 chr5:209038 G/T cg22857025 chr5:266934 NA -1.18 -16.78 -0.68 4.35e-46 Breast cancer; CRC cis rs2576037 0.583 rs10070 chr18:44388899 G/A cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.54 -8.22 -0.41 4.69e-15 Personality dimensions; CRC cis rs12142240 0.698 rs68112720 chr1:46813888 T/C cg14993813 chr1:46806288 NSUN4 -0.5 -6.42 -0.33 4.75e-10 Menopause (age at onset); CRC trans rs2303319 0.504 rs62189055 chr2:162625749 C/A cg14875682 chr5:52083620 ITGA1;PELO -0.76 -6.4 -0.33 5.35e-10 Cognitive function; CRC cis rs2562152 0.744 rs1045001 chr16:107275 G/T cg02949481 chr16:131562 MPG -0.52 -6.34 -0.33 7.68e-10 Glioblastoma; CRC trans rs10242455 0.702 rs116671616 chr7:98954558 C/T cg09045935 chr12:6379348 NA 0.92 7.02 0.36 1.25e-11 Blood metabolite levels; CRC cis rs2294693 0.947 rs736795 chr6:40998141 G/A cg14769373 chr6:40998127 UNC5CL -0.56 -7.46 -0.38 7.65e-13 Gastric cancer;Non-cardia gastric cancer; CRC trans rs10411161 0.702 rs11878583 chr19:52388546 C/T cg22319618 chr22:45562946 NUP50 0.58 6.71 0.35 8.62e-11 Breast cancer; CRC cis rs4862750 0.872 rs1991254 chr4:187875375 T/G cg10295955 chr4:187884368 NA -1.03 -23.79 -0.8 1.75e-73 Lobe attachment (rater-scored or self-reported); CRC cis rs6088580 0.602 rs6058064 chr20:33086622 A/G cg08999081 chr20:33150536 PIGU 0.64 11.46 0.53 8.39e-26 Glomerular filtration rate (creatinine); CRC cis rs910316 0.839 rs35977276 chr14:75637359 A/C cg03030879 chr14:75389066 RPS6KL1 0.5 7.65 0.39 2.2e-13 Height; CRC cis rs4654899 0.758 rs2320826 chr1:21392096 A/C cg02927042 chr1:21476669 EIF4G3 -0.39 -6.14 -0.32 2.37e-9 Superior frontal gyrus grey matter volume; CRC cis rs9905704 0.647 rs12944274 chr17:57041293 C/G cg12560992 chr17:57184187 TRIM37 -0.64 -9.72 -0.47 8.59e-20 Testicular germ cell tumor; CRC trans rs10838798 0.523 rs4752907 chr11:48170581 G/A cg21153622 chr11:89784906 NA -0.47 -7.52 -0.38 5.14e-13 Height; CRC cis rs763014 0.966 rs4984677 chr16:671682 A/G cg08989290 chr16:615782 NHLRC4 0.48 9.19 0.45 4.61e-18 Height; CRC cis rs853679 0.517 rs4713148 chr6:28115921 G/A cg12273811 chr6:28175739 NA 0.73 9.16 0.45 5.8e-18 Depression; CRC cis rs10540 1.000 rs116101630 chr11:506826 G/C cg08200582 chr11:442649 ANO9 -0.73 -7.61 -0.39 2.84e-13 Body mass index; CRC cis rs1185460 1.000 rs1784305 chr11:118942048 G/A cg23280166 chr11:118938394 VPS11 0.4 6.03 0.32 4.41e-9 Coronary artery disease; CRC cis rs947211 0.750 rs5014255 chr1:205753870 C/A cg24503407 chr1:205819492 PM20D1 0.44 6.02 0.32 4.61e-9 Parkinson's disease; CRC cis rs3785574 0.962 rs7219920 chr17:61811642 C/G cg06873352 chr17:61820015 STRADA 0.49 7.95 0.4 3.06e-14 Height; CRC cis rs853679 0.517 rs9368550 chr6:28051803 T/A cg18032046 chr6:28092343 ZSCAN16 -0.5 -5.94 -0.31 7.43e-9 Depression; CRC trans rs10982213 0.830 rs2274163 chr9:117188714 C/T cg09117826 chr6:86303884 SNX14 0.4 5.96 0.31 6.49e-9 Interleukin-6 levels; CRC cis rs669446 0.562 rs11210907 chr1:44191759 C/T cg12908607 chr1:44402522 ARTN -0.34 -5.81 -0.3 1.51e-8 Amyotrophic lateral sclerosis (age of onset); CRC trans rs7615952 0.673 rs3811677 chr3:125648080 G/A cg21747405 chr11:67723411 NA -0.43 -6.1 -0.32 2.97e-9 Blood pressure (smoking interaction); CRC cis rs2635047 0.967 rs1119005 chr18:44725605 A/G cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.42 6.88 0.35 3.12e-11 Educational attainment; CRC cis rs9911578 1.000 rs368186 chr17:56736659 A/G cg12560992 chr17:57184187 TRIM37 0.9 16.62 0.68 1.89e-45 Intelligence (multi-trait analysis); CRC cis rs1594829 0.500 rs2046223 chr8:26210178 C/T cg13160058 chr8:26243215 BNIP3L 0.44 7.77 0.39 9.95e-14 Height; CRC cis rs3820928 0.692 rs2396434 chr2:227775223 G/T cg11843606 chr2:227700838 RHBDD1 -0.48 -7.75 -0.39 1.14e-13 Pulmonary function; CRC cis rs2243480 1.000 rs73142121 chr7:65311206 C/T cg12463550 chr7:65579703 CRCP 0.66 6.14 0.32 2.36e-9 Diabetic kidney disease; CRC cis rs66569888 0.789 rs1317569 chr2:106735490 C/A cg16099169 chr2:106886729 NA -0.54 -8.07 -0.41 1.37e-14 Facial morphology (factor 23); CRC cis rs10504229 1.000 rs67594249 chr8:58180521 T/A cg22535103 chr8:58192502 C8orf71 -0.82 -12.27 -0.56 9.63e-29 Developmental language disorder (linguistic errors); CRC trans rs57221529 0.766 rs58015612 chr5:580665 A/T cg25482853 chr8:67687455 SGK3 1.25 15.0 0.64 4.06e-39 Lung disease severity in cystic fibrosis; CRC cis rs6681460 0.625 rs4488004 chr1:67073314 T/C cg02459107 chr1:67143332 SGIP1 0.35 6.31 0.33 8.78e-10 Presence of antiphospholipid antibodies; CRC cis rs7927592 0.956 rs11228258 chr11:68254328 A/C cg16797656 chr11:68205561 LRP5 -0.39 -6.3 -0.33 9.34e-10 Total body bone mineral density; CRC cis rs270601 0.909 rs2569265 chr5:131704519 T/C cg07395648 chr5:131743802 NA 0.42 5.8 0.3 1.58e-8 Acylcarnitine levels; CRC cis rs7766641 1 rs7766641 chr6:26184102 G/A cg13736514 chr6:26305472 NA -0.46 -7.23 -0.37 3.45e-12 Height; CRC cis rs8180040 0.800 rs2088135 chr3:47280018 T/C cg02527881 chr3:46936655 PTH1R 0.35 5.98 0.31 5.85e-9 Colorectal cancer; CRC cis rs4731207 0.596 rs13234368 chr7:124676054 A/C cg23710748 chr7:124431027 NA -0.39 -6.1 -0.32 2.98e-9 Cutaneous malignant melanoma; CRC cis rs9611565 0.659 rs12483786 chr22:41938536 A/G cg06634786 chr22:41940651 POLR3H -0.69 -8.08 -0.41 1.22e-14 Vitiligo; CRC trans rs2832077 0.943 rs2272701 chr21:30190907 C/T cg14791747 chr16:20752902 THUMPD1 0.53 6.38 0.33 6e-10 Cognitive test performance; CRC cis rs1862618 0.573 rs2591962 chr5:56237155 G/A cg12311346 chr5:56204834 C5orf35 0.94 13.01 0.58 1.66e-31 Initial pursuit acceleration; CRC cis rs11958404 0.517 rs17679725 chr5:157221489 A/G cg05962755 chr5:157440814 NA 0.75 8.89 0.44 4.15e-17 IgG glycosylation; CRC cis rs9928842 0.882 rs3169330 chr16:75269267 A/G cg09066997 chr16:75300724 BCAR1 0.69 6.63 0.34 1.4e-10 Alcoholic chronic pancreatitis; CRC trans rs6601327 0.585 rs11249934 chr8:9510830 C/T cg06636001 chr8:8085503 FLJ10661 0.46 7.0 0.36 1.48e-11 Multiple myeloma (hyperdiploidy); CRC cis rs7737355 1.000 rs12654593 chr5:130756867 C/T cg06307176 chr5:131281290 NA -0.39 -5.91 -0.31 8.68e-9 Life satisfaction; CRC cis rs524281 0.861 rs2177054 chr11:65944612 C/A cg16950941 chr11:66035639 RAB1B -0.61 -7.45 -0.38 8.09e-13 Electroencephalogram traits; CRC trans rs1814175 0.645 rs1851850 chr11:50012168 G/A cg11707556 chr5:10655725 ANKRD33B -0.51 -9.9 -0.48 2.2e-20 Height; CRC cis rs9567406 0.588 rs7981614 chr13:44847936 G/T cg19190762 chr13:44806055 NA -0.5 -5.62 -0.3 4.12e-8 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs4253772 0.550 rs6007818 chr22:46703776 C/T cg24881330 chr22:46731750 TRMU 0.63 7.14 0.37 5.85e-12 LDL cholesterol;Cholesterol, total; CRC cis rs17711722 0.510 rs73142128 chr7:65331109 A/C cg00343986 chr7:65444356 GUSB 0.42 5.84 0.31 1.27e-8 Calcium levels; CRC cis rs7937682 0.889 rs493865 chr11:111495178 A/C cg09085632 chr11:111637200 PPP2R1B -1.0 -19.99 -0.74 9.26e-59 Primary sclerosing cholangitis; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg26496372 chr5:37379396 WDR70 0.44 6.02 0.31 4.61e-9 Response to antipsychotic treatment; CRC cis rs7927592 0.763 rs10896351 chr11:68386896 G/A cg01657329 chr11:68192670 LRP5 -0.54 -8.58 -0.43 3.77e-16 Total body bone mineral density; CRC cis rs7618915 0.547 rs13069481 chr3:52666866 C/T cg18404041 chr3:52824283 ITIH1 -0.42 -8.65 -0.43 2.35e-16 Bipolar disorder; CRC cis rs1552244 0.882 rs3732966 chr3:10015740 C/T cg16606324 chr3:10149918 C3orf24 0.61 7.98 0.4 2.47e-14 Alzheimer's disease; CRC cis rs6860806 0.507 rs272883 chr5:131668698 A/G cg27615366 chr5:131592974 PDLIM4 0.32 5.73 0.3 2.22e-8 Breast cancer; CRC cis rs28655083 0.529 rs285022 chr16:77099730 T/C cg01753188 chr16:77233325 SYCE1L;MON1B 0.48 6.81 0.35 4.54e-11 Lobe attachment (rater-scored or self-reported); CRC cis rs2652834 1.000 rs2729784 chr15:63402735 T/C cg05507819 chr15:63340323 TPM1 0.44 5.61 0.3 4.19e-8 HDL cholesterol; CRC cis rs1624802 1.000 rs1707934 chr12:130497611 C/T cg15444478 chr12:130494697 NA 0.29 6.07 0.32 3.6e-9 Obesity-related traits; CRC cis rs1552244 1.000 rs6786638 chr3:10118075 G/C cg16606324 chr3:10149918 C3orf24 0.72 9.82 0.48 3.92e-20 Alzheimer's disease; CRC cis rs4665809 0.590 rs7582341 chr2:26416301 A/G cg08067268 chr2:26466485 HADHB;HADHA -0.66 -8.45 -0.42 9.58e-16 Gut microbiome composition (summer); CRC cis rs8072100 0.701 rs6503807 chr17:45772932 T/C cg08085267 chr17:45401833 C17orf57 -0.44 -6.41 -0.33 5.05e-10 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs12497850 0.931 rs62262517 chr3:49134914 T/G cg07636037 chr3:49044803 WDR6 0.98 16.17 0.67 1.12e-43 Parkinson's disease; CRC cis rs1799949 1.000 rs12936831 chr17:41331816 C/T cg05368731 chr17:41323189 NBR1 0.67 9.93 0.48 1.65e-20 Menopause (age at onset); CRC cis rs35306767 0.715 rs11253550 chr10:1028288 C/G cg26597838 chr10:835615 NA 0.95 10.61 0.5 8.04e-23 Eosinophil percentage of granulocytes; CRC cis rs6502050 0.835 rs3088177 chr17:80111724 A/G cg02741985 chr17:80059408 CCDC57 0.42 6.91 0.36 2.53e-11 Life satisfaction; CRC cis rs477692 0.544 rs7894836 chr10:131442595 T/A cg05714579 chr10:131428358 MGMT -0.85 -12.91 -0.58 3.9e-31 Response to temozolomide; CRC cis rs9916302 0.555 rs12940193 chr17:37652178 T/G cg03013999 chr17:37608204 MED1 0.45 6.82 0.35 4.29e-11 Glomerular filtration rate (creatinine); CRC cis rs4332037 0.851 rs28728306 chr7:1961814 C/A cg02421172 chr7:1938701 MAD1L1 0.43 5.8 0.3 1.56e-8 Bipolar disorder; CRC cis rs28386778 0.897 rs2665831 chr17:61912392 C/T cg22520471 chr17:61851767 DDX42;CCDC47 0.79 12.28 0.56 8.31e-29 Prudent dietary pattern; CRC trans rs7615952 0.605 rs11708269 chr3:125332150 C/T cg21747405 chr11:67723411 NA -0.59 -6.09 -0.32 3.09e-9 Blood pressure (smoking interaction); CRC cis rs10256972 0.684 rs4724039 chr7:1111633 A/G cg07308232 chr7:1071921 C7orf50 -0.47 -6.71 -0.35 8.76e-11 Longevity;Endometriosis; CRC cis rs4713118 0.629 rs203888 chr6:28021589 C/T cg02683197 chr6:28174875 NA 0.71 9.78 0.47 5.23e-20 Parkinson's disease; CRC cis rs601339 1.000 rs509548 chr12:123181855 T/A cg25190513 chr12:123201362 GPR109B -0.49 -6.2 -0.32 1.73e-9 Adiponectin levels; CRC trans rs10242455 0.702 rs73711293 chr7:99081595 C/T cg09045935 chr12:6379348 NA 1.1 7.89 0.4 4.41e-14 Blood metabolite levels; CRC cis rs3617 0.572 rs2256332 chr3:52855865 A/G cg07507251 chr3:52567010 NT5DC2 -0.4 -6.07 -0.32 3.54e-9 Red blood cell count;Autism spectrum disorder or schizophrenia; CRC cis rs6546537 0.824 rs3771543 chr2:69784255 C/T cg10773587 chr2:69614142 GFPT1 -0.46 -5.89 -0.31 9.74e-9 Serum thyroid-stimulating hormone levels; CRC trans rs6550704 0.687 rs9865314 chr3:22634337 A/G cg20614940 chr2:191273670 MFSD6 -0.44 -6.5 -0.34 2.99e-10 Daytime sleep phenotypes; CRC cis rs8077889 0.956 rs17742347 chr17:41846468 A/G cg26893861 chr17:41843967 DUSP3 -0.98 -12.78 -0.58 1.22e-30 Triglycerides; CRC cis rs7179456 0.593 rs514049 chr15:59042363 A/C cg05156742 chr15:59063176 FAM63B -0.44 -6.86 -0.35 3.33e-11 Asperger disorder; CRC cis rs7463659 1.000 rs7463659 chr8:135432140 T/C cg17885191 chr8:135476712 NA -0.44 -6.57 -0.34 1.98e-10 Colonoscopy-negative controls vs population controls; CRC cis rs1862618 0.853 rs252887 chr5:56166188 A/G cg12311346 chr5:56204834 C5orf35 -0.79 -10.02 -0.48 8.5e-21 Initial pursuit acceleration; CRC cis rs8077889 0.871 rs11079838 chr17:41898971 G/A cg26893861 chr17:41843967 DUSP3 0.92 13.52 0.6 2.02e-33 Triglycerides; CRC cis rs9928842 0.882 rs1107593 chr16:75261329 G/C cg08657710 chr16:75258780 CTRB1 -0.57 -6.45 -0.34 3.9e-10 Alcoholic chronic pancreatitis; CRC cis rs1005277 0.579 rs2472174 chr10:38375382 A/G cg25427524 chr10:38739819 LOC399744 -0.76 -13.54 -0.6 1.67e-33 Extrinsic epigenetic age acceleration; CRC cis rs10751667 1.000 rs4074232 chr11:977682 C/G cg23136738 chr11:925521 AP2A2 -0.51 -8.36 -0.42 1.78e-15 Alzheimer's disease (late onset); CRC cis rs7605827 0.930 rs1125534 chr2:15618339 G/A cg19274914 chr2:15703543 NA 0.39 5.95 0.31 6.89e-9 Educational attainment (years of education); CRC cis rs908922 0.676 rs4845789 chr1:152528100 A/G cg23254163 chr1:152506842 NA 0.45 9.13 0.45 6.92e-18 Hair morphology; CRC cis rs3806843 0.900 rs2261651 chr5:140136804 A/C cg16607685 chr5:140181889 PCDHA2;PCDHA1;PCDHA3 0.25 5.94 0.31 7.35e-9 Depressive symptoms (multi-trait analysis); CRC cis rs477895 0.653 rs11601577 chr11:63928574 C/T cg23719950 chr11:63933701 MACROD1 -0.65 -8.38 -0.42 1.53e-15 Mean platelet volume; CRC cis rs7618915 0.547 rs4687636 chr3:52633929 G/A cg18404041 chr3:52824283 ITIH1 -0.44 -8.95 -0.44 2.69e-17 Bipolar disorder; CRC cis rs755249 0.567 rs61783378 chr1:39777159 G/A cg18385671 chr1:39797026 MACF1 -0.41 -5.84 -0.31 1.22e-8 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs2839186 0.526 rs2839297 chr21:47921839 A/G cg11766577 chr21:47581405 C21orf56 -0.41 -6.34 -0.33 7.36e-10 Testicular germ cell tumor; CRC cis rs7945718 0.805 rs6486059 chr11:12824581 A/G cg25843174 chr11:12811716 TEAD1 -0.44 -8.01 -0.4 1.98e-14 Educational attainment (years of education); CRC cis rs4076764 1.000 rs12740984 chr1:163422151 A/G cg06092702 chr1:163392909 NA 0.56 8.87 0.44 4.61e-17 Motion sickness; CRC cis rs75920871 0.588 rs721783 chr11:116907449 C/T cg01368799 chr11:117014884 PAFAH1B2 -0.43 -5.97 -0.31 6.14e-9 Subjective well-being; CRC cis rs534126 0.813 rs526867 chr7:142904427 G/A cg04182207 chr7:143013161 CLCN1 -0.32 -5.81 -0.31 1.46e-8 Cancer; CRC cis rs6831352 1.000 rs1126673 chr4:100045616 C/T cg12011299 chr4:100065546 ADH4 0.53 11.13 0.52 1.27e-24 Alcohol dependence; CRC cis rs754466 0.651 rs10824584 chr10:79625947 G/A cg26805224 chr10:79626177 DLG5 -0.56 -8.34 -0.42 2.12e-15 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs7493 0.901 rs17879517 chr7:95030646 T/C cg17330251 chr7:94953956 PON1 -0.56 -7.14 -0.37 6.03e-12 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs8067545 0.750 rs4925081 chr17:19991993 A/G cg13482628 chr17:19912719 NA -0.44 -7.45 -0.38 8.31e-13 Schizophrenia; CRC cis rs3008870 0.959 rs2815359 chr1:67494374 T/C cg08660285 chr1:67390436 MIER1;WDR78 1.02 14.93 0.64 7.26e-39 Lymphocyte percentage of white cells; CRC cis rs2635047 1.000 rs2635043 chr18:44679769 A/G cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.42 7.01 0.36 1.34e-11 Educational attainment; CRC cis rs6500602 0.701 rs4785968 chr16:4535307 T/A cg08645402 chr16:4508243 NA 0.58 9.22 0.45 3.73e-18 Schizophrenia; CRC cis rs832540 0.801 rs7731700 chr5:56111927 C/T cg24531977 chr5:56204891 C5orf35 -0.49 -7.32 -0.37 1.95e-12 Coronary artery disease; CRC cis rs10865541 0.869 rs13020433 chr2:3417577 G/A cg22182287 chr2:3452347 TTC15 0.37 5.76 0.3 1.98e-8 Obesity-related traits; CRC cis rs10464366 0.544 rs12668821 chr7:39167846 T/A cg15212455 chr7:39170539 POU6F2 0.5 6.65 0.34 1.21e-10 IgG glycosylation; CRC cis rs7945718 0.967 rs4757945 chr11:12808718 A/G cg25843174 chr11:12811716 TEAD1 -0.48 -8.88 -0.44 4.58e-17 Educational attainment (years of education); CRC trans rs1346081 0.786 rs1425645 chr4:68028175 C/T cg11064797 chr5:141016628 RELL2;HDAC3 0.5 6.15 0.32 2.2e-9 Intelligence (multi-trait analysis); CRC cis rs9969804 0.905 rs4744142 chr9:95391288 C/T cg14631576 chr9:95140430 CENPP -0.31 -5.72 -0.3 2.45e-8 Height; CRC cis rs9648716 1.000 rs7800472 chr7:140600134 T/C cg10747023 chr7:140774559 NA 0.45 5.9 0.31 9.21e-9 Type 2 diabetes; CRC cis rs9372498 0.536 rs77435770 chr6:118819467 G/A cg07617317 chr6:118971624 C6orf204 0.5 6.26 0.33 1.22e-9 Diastolic blood pressure; CRC cis rs11190604 1.000 rs2295776 chr10:102295629 G/T cg16342193 chr10:102329863 NA -0.36 -5.99 -0.31 5.62e-9 Palmitoleic acid (16:1n-7) levels; CRC cis rs870825 0.616 rs4437299 chr4:185643223 T/A cg04058563 chr4:185651563 MLF1IP 0.72 9.42 0.46 8.15e-19 Blood protein levels; CRC cis rs9916302 0.800 rs8081220 chr17:37473157 A/C cg00129232 chr17:37814104 STARD3 0.55 8.09 0.41 1.14e-14 Glomerular filtration rate (creatinine); CRC cis rs12926788 0.546 rs200537 chr16:24747787 G/C cg04756594 chr16:24857601 SLC5A11 -0.32 -6.71 -0.35 8.58e-11 Ejection fraction in Tripanosoma cruzi seropositivity; CRC cis rs7927771 0.832 rs10838699 chr11:47386073 T/C cg05585544 chr11:47624801 NA 0.5 8.89 0.44 3.99e-17 Subjective well-being; CRC cis rs17155006 0.664 rs1735499 chr7:107738882 G/A cg05962710 chr7:107745446 LAMB4 -0.43 -7.53 -0.38 4.79e-13 Pneumococcal bacteremia; CRC cis rs4731207 0.564 rs6466964 chr7:124572400 T/C cg23710748 chr7:124431027 NA -0.39 -6.19 -0.32 1.8e-9 Cutaneous malignant melanoma; CRC cis rs7539542 0.577 rs6662398 chr1:202888456 T/G cg19681188 chr1:202830198 LOC148709 0.45 6.51 0.34 2.81e-10 Mean platelet volume; CRC cis rs10791097 0.694 rs4264159 chr11:130755784 G/T cg12179176 chr11:130786555 SNX19 0.75 12.45 0.57 2e-29 Autism spectrum disorder or schizophrenia;Schizophrenia; CRC cis rs1018836 0.923 rs4735256 chr8:91612145 C/G cg16814680 chr8:91681699 NA -0.76 -12.11 -0.56 3.77e-28 Ejection fraction in Tripanosoma cruzi seropositivity; CRC cis rs651907 0.557 rs11711079 chr3:101386918 G/A cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.62 8.41 0.42 1.3e-15 Colorectal cancer; CRC cis rs8105895 0.799 rs6511327 chr19:22286899 T/A cg02912127 chr19:22235281 ZNF257 -0.38 -5.63 -0.3 3.9e-8 Body mass index (change over time); CRC cis rs55665837 1.000 rs11023227 chr11:14459087 T/C cg19336497 chr11:14380999 RRAS2 -0.39 -6.64 -0.34 1.33e-10 Vitamin D levels; CRC cis rs7534824 0.543 rs61780317 chr1:101407139 T/C cg16556008 chr1:101360663 SLC30A7;EXTL2 0.61 6.41 0.33 4.92e-10 Refractive astigmatism; CRC cis rs6840360 0.615 rs56319216 chr4:152463716 C/T cg09659197 chr4:152720779 NA 0.31 5.64 0.3 3.65e-8 Intelligence (multi-trait analysis); CRC trans rs1456896 0.835 rs921913 chr7:50311099 G/A cg02134594 chr1:3632713 TP73 0.38 6.27 0.33 1.14e-9 Inflammatory bowel disease;Crohn's disease; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg00777555 chr3:57583074 ARF4 0.52 7.36 0.38 1.45e-12 Response to antipsychotic treatment; CRC cis rs72781680 0.678 rs11125293 chr2:24102423 A/G cg08917208 chr2:24149416 ATAD2B 0.53 6.37 0.33 6.54e-10 Lymphocyte counts; CRC cis rs9487051 0.676 rs6933326 chr6:109601333 C/T cg01475377 chr6:109611718 NA -0.36 -6.37 -0.33 6.48e-10 Reticulocyte fraction of red cells; CRC cis rs3087591 0.708 rs17885030 chr17:29655218 C/T cg24425628 chr17:29625626 OMG;NF1 0.71 12.7 0.57 2.34e-30 Hip circumference; CRC cis rs7208859 0.562 rs11650923 chr17:29008167 G/A cg14008862 chr17:28927542 LRRC37B2 0.59 5.82 0.31 1.4e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs6500395 1.000 rs7190106 chr16:48705542 C/T cg04672837 chr16:48644449 N4BP1 0.44 6.53 0.34 2.5e-10 Response to tocilizumab in rheumatoid arthritis; CRC cis rs6499129 1.000 rs8063771 chr16:67506115 C/T cg26727032 chr16:67993705 SLC12A4 -0.6 -7.16 -0.37 5.31e-12 Waist-to-hip ratio adjusted for body mass index; CRC cis rs8062405 1.000 rs62037367 chr16:28874547 C/G cg08761264 chr16:28874980 SH2B1 -0.44 -5.83 -0.31 1.33e-8 Cognitive ability (multi-trait analysis);Cognitive ability; CRC cis rs10504229 0.683 rs11785260 chr8:58132906 A/G cg04204079 chr8:58130323 NA -0.45 -5.78 -0.3 1.71e-8 Developmental language disorder (linguistic errors); CRC cis rs34172651 0.517 rs36113933 chr16:24838862 A/G cg04756594 chr16:24857601 SLC5A11 0.3 6.15 0.32 2.29e-9 Intelligence (multi-trait analysis); CRC cis rs6952808 1.000 rs4449693 chr7:1884630 G/C cg04267008 chr7:1944627 MAD1L1 -0.75 -10.61 -0.5 8.15e-23 Bipolar disorder and schizophrenia; CRC cis rs977987 0.778 rs12930452 chr16:75462055 A/G cg03315344 chr16:75512273 CHST6 0.55 9.25 0.45 3.01e-18 Dupuytren's disease; CRC cis rs9894429 0.934 rs35868252 chr17:79575472 C/G cg21028142 chr17:79581711 NPLOC4 -0.39 -8.62 -0.43 2.89e-16 Eye color traits; CRC cis rs6952809 0.532 rs7803015 chr7:2432143 G/A cg23289794 chr7:2394357 EIF3B -0.69 -8.78 -0.44 9.07e-17 Multiple sclerosis; CRC cis rs826838 0.933 rs1906263 chr12:38653362 T/C cg13010199 chr12:38710504 ALG10B 0.45 6.01 0.31 4.84e-9 Heart rate; CRC cis rs9311474 1.000 rs2276834 chr3:52325759 A/G cg08222913 chr3:52553049 STAB1 -0.37 -6.99 -0.36 1.56e-11 Electroencephalogram traits; CRC cis rs10751667 0.666 rs10902249 chr11:958566 C/T ch.11.42038R chr11:967971 AP2A2 -0.57 -9.85 -0.48 3.1e-20 Alzheimer's disease (late onset); CRC cis rs12580194 0.593 rs61957937 chr12:55746850 G/C cg19537932 chr12:55886519 OR6C68 -0.72 -9.1 -0.45 9.11e-18 Cancer; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg06522697 chr10:121356224 TIAL1 0.47 7.35 0.38 1.54e-12 Liver disease severity in Alagille syndrome; CRC cis rs9910055 0.960 rs9911991 chr17:42278916 G/C cg16434002 chr17:42200994 HDAC5 -0.45 -6.0 -0.31 5.1e-9 Total body bone mineral density; CRC cis rs10504229 1.000 rs72650899 chr8:58180525 G/T cg02725872 chr8:58115012 NA -0.38 -6.43 -0.33 4.44e-10 Developmental language disorder (linguistic errors); CRC trans rs10982213 0.830 rs2274163 chr9:117188714 C/T cg15433164 chr3:25824899 NGLY1 0.32 6.07 0.32 3.58e-9 Interleukin-6 levels; CRC cis rs11229555 0.645 rs56228632 chr11:58187444 A/G cg15696309 chr11:58395628 NA -0.82 -10.31 -0.49 8.59e-22 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; CRC cis rs7044106 0.762 rs966397 chr9:123453312 G/A cg14255062 chr9:123606675 PSMD5;LOC253039 0.45 6.87 0.35 3.18e-11 Hip circumference adjusted for BMI; CRC cis rs6502050 0.835 rs7218857 chr17:80161000 T/C cg19223190 chr17:80058835 NA 0.41 6.7 0.35 8.79e-11 Life satisfaction; CRC cis rs12541335 0.639 rs6993855 chr8:22163797 A/G cg09517075 chr8:22133004 PIWIL2 0.44 7.56 0.38 4.08e-13 Hypertriglyceridemia; CRC cis rs7811142 0.830 rs76798830 chr7:99952828 C/T cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.09 14.63 0.63 1.06e-37 Platelet count; CRC cis rs798554 0.679 rs1636249 chr7:2884283 T/G cg04166393 chr7:2884313 GNA12 0.53 7.44 0.38 8.75e-13 Height; CRC cis rs72945132 0.882 rs1061328 chr11:70185325 C/T cg00319359 chr11:70116639 PPFIA1 0.65 7.24 0.37 3.14e-12 Coronary artery disease; CRC cis rs975210 0.652 rs4777230 chr15:70365762 A/G cg01666796 chr15:70364327 TLE3 -0.71 -5.61 -0.3 4.2e-8 Height;Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction);Waist circumference adjusted for BMI in active individuals;Waist circumference adjusted for body mass index; CRC cis rs8060686 0.641 rs3743735 chr16:68119555 G/A cg08314208 chr16:67682810 RLTPR -0.55 -5.96 -0.31 6.57e-9 HDL cholesterol;Metabolic syndrome; CRC trans rs564309 0.681 rs1188473 chr1:228612444 A/G cg20905516 chr11:106889364 GUCY1A2 0.58 6.15 0.32 2.26e-9 Hip circumference (psychosocial stress interaction); CRC cis rs6461049 0.765 rs10224497 chr7:2149967 A/G cg08027265 chr7:2291960 NA -0.34 -5.93 -0.31 7.58e-9 Schizophrenia; CRC trans rs13067260 1.000 rs6438827 chr3:123796759 C/T cg18317531 chr1:225688425 ENAH -0.58 -5.99 -0.31 5.57e-9 PR interval in Tripanosoma cruzi seropositivity; CRC cis rs216303 1.000 rs216299 chr12:6156635 A/G cg19878637 chr12:6148451 VWF -0.54 -6.34 -0.33 7.41e-10 Low vWF levels; CRC cis rs7917772 0.503 rs2031601 chr10:104308064 T/G cg22532475 chr10:104410764 TRIM8 -0.37 -6.95 -0.36 1.99e-11 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC cis rs9368481 0.729 rs10946881 chr6:26914611 C/T cg05192639 chr6:26864778 GUSBL1 0.34 6.16 0.32 2.12e-9 Autism spectrum disorder or schizophrenia; CRC cis rs875971 0.545 rs801212 chr7:66015630 C/G cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.55 -7.11 -0.37 7.2e-12 Aortic root size; CRC cis rs9649213 0.574 rs7790229 chr7:97919338 G/A cg21770322 chr7:97807741 LMTK2 0.52 8.6 0.43 3.4e-16 Prostate cancer (SNP x SNP interaction); CRC cis rs3771570 0.786 rs62186396 chr2:242221219 A/G cg21155796 chr2:242212141 HDLBP 0.64 7.0 0.36 1.48e-11 Prostate cancer; CRC cis rs2952156 0.684 rs1877031 chr17:37814080 G/A cg20243544 chr17:37824526 PNMT 0.54 8.73 0.43 1.33e-16 Asthma; CRC cis rs10782582 0.593 rs12130832 chr1:76234294 T/C cg03433033 chr1:76189801 ACADM -0.44 -6.39 -0.33 5.51e-10 Daytime sleep phenotypes; CRC cis rs1451375 0.729 rs6593017 chr7:50644812 G/A cg18232548 chr7:50535776 DDC 0.44 6.25 0.33 1.24e-9 Malaria; CRC cis rs6951245 1.000 rs77305932 chr7:1100861 T/A cg26224354 chr7:1096374 C7orf50;GPR146 -0.93 -12.05 -0.55 5.9e-28 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs7223966 0.960 rs113155878 chr17:61706560 C/A cg23090583 chr17:61904693 PSMC5;FTSJ3 0.53 6.38 0.33 6.09e-10 Hip circumference adjusted for BMI;Body mass index; CRC cis rs7727544 0.606 rs11950562 chr5:131652529 A/C cg04518342 chr5:131593106 PDLIM4 0.32 5.68 0.3 2.95e-8 Blood metabolite levels; CRC cis rs4665809 1.000 rs1550381 chr2:26266946 A/G cg25036284 chr2:26402008 FAM59B -0.46 -6.02 -0.32 4.53e-9 Gut microbiome composition (summer); CRC cis rs919433 0.680 rs788021 chr2:198293691 T/C cg10820045 chr2:198174542 NA 0.38 6.25 0.33 1.29e-9 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC cis rs929354 0.772 rs1182442 chr7:157026633 G/A cg16102536 chr7:156981717 UBE3C -0.4 -6.8 -0.35 4.8e-11 Body mass index; CRC trans rs7267979 1.000 rs6050598 chr20:25397257 C/G cg17903999 chr18:56338584 MALT1 -0.42 -7.09 -0.36 8.4e-12 Liver enzyme levels (alkaline phosphatase); CRC cis rs6121246 0.909 rs6060923 chr20:30336655 A/C cg18721089 chr20:30220636 NA -0.36 -5.86 -0.31 1.12e-8 Mean corpuscular hemoglobin; CRC cis rs7617773 0.780 rs35190747 chr3:48343290 C/T cg11946769 chr3:48343235 NME6 0.72 9.63 0.47 1.74e-19 Coronary artery disease; CRC cis rs4716602 0.542 rs10261485 chr7:156159775 C/T cg16983916 chr7:156159713 NA -0.4 -6.92 -0.36 2.41e-11 Anti-saccade response; CRC cis rs1499614 1.000 rs2659911 chr7:66158420 G/A cg25985355 chr7:65971099 NA -0.52 -5.92 -0.31 7.91e-9 Gout; CRC cis rs4713118 0.911 rs2394000 chr6:27686991 A/G cg15786705 chr6:28176104 NA 0.51 6.67 0.35 1.06e-10 Parkinson's disease; CRC cis rs2976388 0.934 rs2920279 chr8:143762135 A/C cg22687807 chr8:143858763 LYNX1 -0.36 -6.17 -0.32 2.02e-9 Urinary tract infection frequency; CRC cis rs2303759 0.918 rs2288480 chr19:49867016 C/G cg22590775 chr19:49891494 CCDC155 0.64 9.27 0.46 2.53e-18 Multiple sclerosis; CRC cis rs501120 0.564 rs10899999 chr10:44690185 A/G cg09554077 chr10:44749378 NA 0.58 8.13 0.41 8.75e-15 Coronary artery disease;Coronary heart disease; CRC cis rs2243480 1.000 rs2460422 chr7:65601505 C/T cg18252515 chr7:66147081 NA -1.25 -14.84 -0.63 1.63e-38 Diabetic kidney disease; CRC cis rs7487075 0.578 rs1492895 chr12:46808755 C/T cg22049899 chr12:47219821 SLC38A4 0.31 5.67 0.3 3.17e-8 Itch intensity from mosquito bite; CRC cis rs7725052 0.609 rs4957295 chr5:40447997 G/A cg09067459 chr5:40385259 NA -0.4 -6.64 -0.34 1.3100000000000001e-10 Pediatric autoimmune diseases; CRC cis rs10911232 0.507 rs3934697 chr1:183027512 A/G ch.1.3577855R chr1:183094577 LAMC1 0.83 14.62 0.63 1.24e-37 Hypertriglyceridemia; CRC cis rs7208859 0.623 rs35916850 chr17:29011173 G/A cg01831904 chr17:28903510 LRRC37B2 -0.64 -6.28 -0.33 1.06e-9 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs2275731 0.525 rs7922050 chr10:16479007 C/G cg04254609 chr10:16479192 PTER -0.58 -8.65 -0.43 2.23e-16 Bone fracture in osteoporosis; CRC cis rs17433780 0.892 rs72726528 chr1:89455980 C/A cg09516651 chr1:89888402 LOC400759 0.46 6.89 0.36 2.82e-11 Carotid intima media thickness; CRC trans rs7395662 1.000 rs7478900 chr11:48544003 T/C cg21153622 chr11:89784906 NA -0.45 -7.17 -0.37 5.09e-12 HDL cholesterol; CRC cis rs801193 0.569 rs11761542 chr7:66218196 G/A cg12463550 chr7:65579703 CRCP 0.45 6.04 0.32 4.12e-9 Aortic root size; CRC cis rs7918232 0.830 rs7915902 chr10:27410734 T/C cg14442939 chr10:27389572 ANKRD26 0.82 9.16 0.45 5.68e-18 Breast cancer; CRC cis rs1153858 1.000 rs4775909 chr15:45643042 T/C cg10760299 chr15:45669010 GATM 0.48 7.58 0.39 3.6e-13 Homoarginine levels; CRC cis rs853679 0.517 rs9380047 chr6:28037893 G/T cg02683197 chr6:28174875 NA 0.78 9.5 0.46 4.55e-19 Depression; CRC cis rs35306767 0.903 rs11815185 chr10:923617 T/A cg20503657 chr10:835505 NA 0.94 11.83 0.55 3.85e-27 Eosinophil percentage of granulocytes; CRC cis rs17767392 0.958 rs61989373 chr14:71935156 C/T cg13720639 chr14:72061746 SIPA1L1 -0.56 -7.17 -0.37 5.11e-12 Mitral valve prolapse; CRC cis rs597539 0.731 rs664229 chr11:68624483 C/G cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.85 13.85 0.61 1.11e-34 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs951366 1.000 rs951366 chr1:205685352 C/T cg11965913 chr1:205819406 PM20D1 0.41 5.91 0.31 8.71e-9 Menarche (age at onset); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg01638175 chr3:49171179 LAMB2 0.41 6.27 0.33 1.13e-9 Response to antipsychotic treatment; CRC trans rs7618501 0.699 rs2681780 chr3:49897830 C/T cg21659725 chr3:3221576 CRBN 0.68 10.69 0.51 4.28e-23 Intelligence (multi-trait analysis); CRC cis rs6546550 0.869 rs6720498 chr2:70124805 T/C cg02498382 chr2:70120550 SNRNP27 -0.55 -9.09 -0.45 9.27e-18 Prevalent atrial fibrillation; CRC cis rs992157 0.835 rs4674282 chr2:219144230 A/T cg04731861 chr2:219085781 ARPC2 0.32 6.72 0.35 8.11e-11 Colorectal cancer; CRC cis rs9814567 1.000 rs1138273 chr3:134261437 T/C cg06109529 chr3:134205091 CEP63;ANAPC13 -0.82 -12.4 -0.56 3.1e-29 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs3804749 0.966 rs4677875 chr3:122841062 G/A cg26084141 chr3:122786895 PDIA5 0.22 6.0 0.31 5.19e-9 Plateletcrit;Mean platelet volume;Platelet count;Platelet distribution width; CRC cis rs12142240 0.698 rs9661240 chr1:46827050 G/A cg00530320 chr1:46809349 NSUN4 0.59 8.03 0.41 1.69e-14 Menopause (age at onset); CRC cis rs11958404 0.932 rs72816540 chr5:157414500 T/C cg05962755 chr5:157440814 NA 0.74 10.37 0.5 5.47e-22 IgG glycosylation; CRC cis rs721399 0.553 rs10109286 chr8:18243603 A/G cg24555670 chr8:18244502 NA 0.49 5.62 0.3 4.05e-8 Blood metabolite levels; CRC cis rs7215564 0.908 rs4969246 chr17:78740579 G/A cg09596252 chr17:78655493 RPTOR -0.58 -6.07 -0.32 3.43e-9 Myopia (pathological); CRC cis rs7618915 0.547 rs12486847 chr3:52691112 T/C cg05573699 chr3:52720067 GNL3;PBRM1 -0.45 -6.32 -0.33 8.47e-10 Bipolar disorder; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg25220896 chr1:11004296 NA 0.42 6.63 0.34 1.42e-10 Response to antipsychotic treatment; CRC cis rs908922 0.566 rs12144049 chr1:152440910 C/T cg09873164 chr1:152488093 CRCT1 0.38 5.79 0.3 1.62e-8 Hair morphology; CRC cis rs2952156 0.883 rs2941505 chr17:37832704 A/G cg00129232 chr17:37814104 STARD3 -0.67 -11.66 -0.54 1.52e-26 Asthma; CRC cis rs72634258 0.945 rs67717282 chr1:8041290 C/T cg00042356 chr1:8021962 PARK7 0.7 7.68 0.39 1.9e-13 Inflammatory bowel disease; CRC cis rs801193 1.000 rs2286684 chr7:66129830 G/T cg11764359 chr7:65958608 NA -0.54 -8.3 -0.42 2.71e-15 Aortic root size; CRC cis rs10540 1.000 rs61876336 chr11:489537 C/T cg21784768 chr11:537496 LRRC56 -0.66 -6.13 -0.32 2.48e-9 Body mass index; CRC cis rs10486722 0.624 rs4724069 chr7:41775278 C/T cg22138096 chr7:41772439 LOC285954 -0.38 -5.83 -0.31 1.35e-8 Pit-and-Fissure caries; CRC cis rs9902453 0.765 rs3102555 chr17:28044101 C/T cg26525008 chr17:28256777 EFCAB5;SSH2 0.7 11.72 0.54 9.5e-27 Coffee consumption (cups per day); CRC cis rs7666738 1.000 rs880471 chr4:98922541 C/T cg05340658 chr4:99064831 C4orf37 0.52 7.4 0.38 1.17e-12 Colonoscopy-negative controls vs population controls; CRC cis rs10128264 0.967 rs942794 chr10:80965109 T/C cg20744163 chr10:80999841 ZMIZ1 -0.37 -6.7 -0.35 9.08e-11 Response to methotrexate in juvenile idiopathic arthritis; CRC cis rs10463316 0.817 rs1508772 chr5:150816561 A/C cg03212797 chr5:150827313 SLC36A1 -0.52 -8.03 -0.4 1.78e-14 Metabolite levels (Pyroglutamine); CRC cis rs72634258 0.945 rs12740409 chr1:8027830 A/C cg00042356 chr1:8021962 PARK7 0.72 7.53 0.38 4.8e-13 Inflammatory bowel disease; CRC trans rs1005277 0.579 rs1780136 chr10:38501453 A/G cg17830980 chr10:43048298 ZNF37B -0.57 -9.66 -0.47 1.38e-19 Extrinsic epigenetic age acceleration; CRC cis rs2153535 0.563 rs4428546 chr6:8490376 A/G cg07606381 chr6:8435919 SLC35B3 0.67 10.69 0.51 4.33e-23 Motion sickness; CRC cis rs7043114 0.525 rs8067 chr9:95218829 G/T cg14631576 chr9:95140430 CENPP -0.32 -6.1 -0.32 3.02e-9 Height; CRC cis rs7107174 1.000 rs6592772 chr11:78015563 A/C cg02023728 chr11:77925099 USP35 0.53 7.49 0.38 6.52e-13 Testicular germ cell tumor; CRC cis rs1559088 0.847 rs7254758 chr19:33608047 T/A cg27124370 chr19:33622961 WDR88 0.44 6.04 0.32 4.14e-9 Bone ultrasound measurement (broadband ultrasound attenuation); CRC cis rs9462027 0.628 rs7776219 chr6:34784667 C/G cg07306190 chr6:34760872 UHRF1BP1 -0.34 -6.06 -0.32 3.62e-9 Systemic lupus erythematosus; CRC cis rs10504229 0.545 rs56394419 chr8:58128982 T/C cg21724239 chr8:58056113 NA 0.49 6.81 0.35 4.75e-11 Developmental language disorder (linguistic errors); CRC cis rs3018066 0.666 rs28507027 chr4:107035423 C/A cg01869342 chr4:106983673 TBCK 0.46 6.03 0.32 4.52e-9 Cancer; CRC cis rs514406 0.661 rs562641 chr1:53374666 C/T cg24675658 chr1:53192096 ZYG11B -0.7 -10.17 -0.49 2.57e-21 Monocyte count; CRC cis rs875971 0.545 rs11770063 chr7:65783016 G/A cg05627663 chr7:65219948 SNORA22;CCT6P1 0.61 7.87 0.4 5.25e-14 Aortic root size; CRC trans rs1814175 0.765 rs11493326 chr11:50018063 T/C cg11707556 chr5:10655725 ANKRD33B -0.42 -7.97 -0.4 2.66e-14 Height; CRC cis rs2115630 0.936 rs11073663 chr15:85260268 A/G cg09876464 chr15:85330779 ZNF592 0.46 7.58 0.39 3.47e-13 P wave terminal force; CRC cis rs10463316 0.862 rs1983171 chr5:150778691 A/G cg03212797 chr5:150827313 SLC36A1 -0.53 -8.25 -0.41 3.85e-15 Metabolite levels (Pyroglutamine); CRC cis rs6694672 1.000 rs2336597 chr1:196993339 C/T cg13682187 chr1:196946512 CFHR5 -0.49 -7.68 -0.39 1.88e-13 Asthma; CRC cis rs17162190 0.698 rs7539320 chr1:26850665 C/T cg17456097 chr1:26900765 RPS6KA1 0.42 5.94 0.31 7.38e-9 Mean corpuscular volume; CRC cis rs6445525 0.967 rs6782159 chr3:65993782 C/G cg06109867 chr3:66002991 MAGI1 -0.38 -6.23 -0.32 1.46e-9 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs9908102 0.740 rs73981621 chr17:12914832 C/T cg26162695 chr17:12921313 ELAC2 0.44 5.91 0.31 8.44e-9 Schizophrenia; CRC cis rs9486719 1.000 rs12190397 chr6:97036465 G/A cg06623918 chr6:96969491 KIAA0776 -0.81 -9.44 -0.46 7.3e-19 Migraine;Coronary artery disease; CRC cis rs394563 0.517 rs377454 chr6:149791093 T/C cg07828024 chr6:149772892 ZC3H12D -0.49 -7.94 -0.4 3.26e-14 Dupuytren's disease; CRC cis rs2072499 0.966 rs11587860 chr1:156156951 G/C cg24450063 chr1:156163899 SLC25A44 1.14 26.32 0.82 5.65e-83 Testicular germ cell tumor; CRC cis rs8141529 0.871 rs5762877 chr22:29277555 G/A cg02153584 chr22:29168773 CCDC117 0.41 5.71 0.3 2.47e-8 Lymphocyte counts; CRC cis rs10267417 0.544 rs2072185 chr7:19748700 G/A cg07541023 chr7:19748670 TWISTNB 1.07 13.98 0.61 3.39e-35 Night sleep phenotypes; CRC cis rs950169 0.922 rs11639244 chr15:84832650 G/A cg11189052 chr15:85197271 WDR73 0.59 8.26 0.41 3.66e-15 Schizophrenia; CRC cis rs2997447 0.595 rs3008425 chr1:26385660 T/C cg00300879 chr1:26503847 CNKSR1 0.29 5.83 0.31 1.31e-8 QRS complex (12-leadsum); CRC cis rs939584 0.935 rs11127490 chr2:646110 C/T cg03610516 chr2:642275 NA 0.42 5.87 0.31 1.06e-8 Body mass index; CRC cis rs68170813 0.523 rs111590023 chr7:107055323 T/C cg23293999 chr7:106826042 HBP1 -0.5 -5.81 -0.31 1.46e-8 Coronary artery disease; CRC cis rs10242455 0.702 rs917152 chr7:99004497 T/C cg18809830 chr7:99032528 PTCD1 -1.08 -7.96 -0.4 2.89e-14 Blood metabolite levels; CRC cis rs4713118 0.869 rs9393851 chr6:27699581 A/T cg25164649 chr6:28176230 NA 0.58 8.19 0.41 5.97e-15 Parkinson's disease; CRC cis rs3858526 0.523 rs10742818 chr11:5882535 T/C cg13902645 chr11:5959945 NA -0.67 -9.58 -0.47 2.43e-19 DNA methylation (variation); CRC cis rs7945705 0.738 rs11042067 chr11:8815453 T/C cg21881798 chr11:8931708 C11orf17;ST5 -0.57 -9.37 -0.46 1.17e-18 Hemoglobin concentration; CRC trans rs2840044 1.000 rs17637907 chr17:33891386 A/G cg19694781 chr19:47549865 TMEM160 0.43 6.82 0.35 4.36e-11 Response to radiotherapy in cancer (late toxicity); CRC cis rs6502050 0.723 rs11650635 chr17:80083816 T/C cg19223190 chr17:80058835 NA -0.39 -6.24 -0.33 1.31e-9 Life satisfaction; CRC cis rs1707322 1.000 rs4660896 chr1:46372416 A/G cg06784218 chr1:46089804 CCDC17 0.52 9.12 0.45 7.88e-18 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs2811415 0.597 rs67786346 chr3:127794654 C/G cg13719885 chr3:127795394 NA -0.39 -5.84 -0.31 1.27e-8 Lung function (FEV1/FVC); CRC cis rs6860806 0.507 rs273915 chr5:131660119 G/C cg02033258 chr5:131593261 PDLIM4 0.38 6.41 0.33 5.01e-10 Breast cancer; CRC cis rs1348850 0.958 rs10930801 chr2:178459861 G/A cg22681709 chr2:178499509 PDE11A -0.35 -6.45 -0.34 4e-10 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs172166 0.694 rs1225716 chr6:28113746 A/C cg20615401 chr6:28092323 ZSCAN16 0.45 5.89 0.31 9.65e-9 Cardiac Troponin-T levels; CRC trans rs6479874 0.831 rs2245543 chr10:52745148 C/A cg15483030 chr1:5935144 NPHP4 -0.71 -6.34 -0.33 7.64e-10 Migraine; CRC cis rs9814567 0.806 rs9841371 chr3:134320765 A/G cg06109529 chr3:134205091 CEP63;ANAPC13 -0.68 -10.11 -0.49 4.15e-21 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs10504229 0.683 rs7460059 chr8:58111561 C/T cg22535103 chr8:58192502 C8orf71 -0.7 -9.2 -0.45 4.33e-18 Developmental language disorder (linguistic errors); CRC cis rs6952808 0.729 rs35797753 chr7:1954914 G/A cg00106254 chr7:1943704 MAD1L1 -0.5 -7.35 -0.38 1.58e-12 Bipolar disorder and schizophrenia; CRC cis rs651907 0.557 rs34376498 chr3:101480156 C/T cg12386194 chr3:101231763 SENP7 0.53 7.66 0.39 2.04e-13 Colorectal cancer; CRC trans rs2243480 1.000 rs34560516 chr7:65404092 A/T cg10756647 chr7:56101905 PSPH 0.7 7.47 0.38 7.51e-13 Diabetic kidney disease; CRC cis rs9487051 0.837 rs9480920 chr6:109605322 C/A cg21918786 chr6:109611834 NA -0.44 -8.06 -0.41 1.45e-14 Reticulocyte fraction of red cells; CRC cis rs826838 0.616 rs7966266 chr12:38626138 G/A cg26384229 chr12:38710491 ALG10B -0.52 -7.52 -0.38 5.28e-13 Heart rate; CRC trans rs10090774 0.760 rs6993266 chr8:141762659 G/A cg14360659 chr9:137029702 RNU6ATAC -0.47 -6.15 -0.32 2.23e-9 Acute graft versus host disease in bone marrow transplantation (recipient effect); CRC cis rs7589728 0.563 rs12479338 chr2:88444513 C/T cg18490616 chr2:88469792 THNSL2 0.61 6.1 0.32 2.9e-9 Plasma clusterin levels; CRC cis rs9916302 0.904 rs34363096 chr17:37594294 G/A cg15445000 chr17:37608096 MED1 0.44 9.68 0.47 1.12e-19 Glomerular filtration rate (creatinine); CRC cis rs9584850 0.834 rs17574378 chr13:99116384 T/C cg07423050 chr13:99094983 FARP1 0.42 6.03 0.32 4.33e-9 Neuroticism; CRC cis rs11628318 0.525 rs10129838 chr14:103154317 T/C cg23461800 chr14:103021989 NA 0.57 6.53 0.34 2.47e-10 Platelet count; CRC cis rs7666738 0.830 rs1869897 chr4:98730997 C/T cg17366294 chr4:99064904 C4orf37 0.42 6.91 0.36 2.59e-11 Colonoscopy-negative controls vs population controls; CRC cis rs4728302 0.643 rs2346442 chr7:133705907 A/G cg10665199 chr7:133106180 EXOC4 -0.36 -5.71 -0.3 2.53e-8 Intelligence;Intelligence (multi-trait analysis); CRC cis rs9640161 0.789 rs1464751 chr7:150021282 C/T cg12556325 chr7:150026731 C7orf29;LRRC61 -0.41 -6.19 -0.32 1.81e-9 Blood protein levels;Circulating chemerin levels; CRC trans rs12478296 1.000 rs73007129 chr2:243000555 T/C cg18288967 chr1:45987694 PRDX1 0.65 6.58 0.34 1.82e-10 Obesity-related traits; CRC cis rs11711311 0.712 rs6795099 chr3:113338782 A/G cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.49 -6.66 -0.34 1.12e-10 IgG glycosylation; CRC cis rs11098499 0.874 rs6826823 chr4:120112098 G/C cg09307838 chr4:120376055 NA 0.61 8.95 0.44 2.69e-17 Corneal astigmatism; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg00114008 chr1:27114423 PIGV 0.37 6.28 0.33 1.06e-9 Liver disease severity in Alagille syndrome; CRC cis rs1403694 1.000 rs1656911 chr3:186439373 T/C cg04611788 chr3:186434169 KNG1 -0.45 -6.96 -0.36 1.83e-11 Blood protein levels; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg21886851 chr18:47340405 SCARNA17;ACAA2 0.4 6.32 0.33 8.46e-10 Liver disease severity in Alagille syndrome; CRC cis rs9875589 0.957 rs6768050 chr3:13930490 A/G cg19554555 chr3:13937349 NA 0.43 6.19 0.32 1.81e-9 Ovarian reserve; CRC cis rs9807989 0.524 rs6759479 chr2:103040047 A/C cg03938978 chr2:103052716 IL18RAP 0.58 9.87 0.48 2.63e-20 Asthma; CRC cis rs76878669 0.561 rs4930362 chr11:66154360 T/C cg24851651 chr11:66362959 CCS -0.4 -6.94 -0.36 2.08e-11 Educational attainment (years of education); CRC cis rs34779708 0.966 rs12784482 chr10:35446865 A/G cg03585969 chr10:35415529 CREM 0.66 8.75 0.43 1.14e-16 Inflammatory bowel disease;Crohn's disease; CRC cis rs9487051 0.768 rs9480910 chr6:109521707 T/C cg21918786 chr6:109611834 NA -0.33 -5.63 -0.3 3.82e-8 Reticulocyte fraction of red cells; CRC cis rs11122272 0.735 rs973252 chr1:231520802 A/G cg06096015 chr1:231504339 EGLN1 0.4 5.94 0.31 7.17e-9 Hemoglobin concentration; CRC cis rs1816752 0.905 rs4769352 chr13:25000375 G/A cg02811702 chr13:24901961 NA 0.45 6.22 0.32 1.53e-9 Obesity-related traits; CRC cis rs3764563 1.000 rs8107240 chr19:15737392 A/G cg20725493 chr19:15740067 CYP4F8 -0.75 -7.61 -0.39 2.89e-13 Inflammatory biomarkers; CRC cis rs2839186 0.770 rs2839984 chr21:47671690 A/G cg11766577 chr21:47581405 C21orf56 -0.47 -7.57 -0.39 3.68e-13 Testicular germ cell tumor; CRC cis rs9463078 0.608 rs608941 chr6:44888740 C/T cg25276700 chr6:44698697 NA -0.25 -6.06 -0.32 3.71e-9 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; CRC cis rs66569888 0.789 rs66826026 chr2:106732879 C/T cg15412446 chr2:106886593 NA -0.5 -6.97 -0.36 1.7e-11 Facial morphology (factor 23); CRC trans rs10982213 0.830 rs2274163 chr9:117188714 C/T cg13468249 chr17:7154818 DULLARD;C17orf81 0.42 6.59 0.34 1.76e-10 Interleukin-6 levels; CRC cis rs2795502 0.882 rs2744095 chr10:43337949 A/T cg20628663 chr10:43360327 NA -0.69 -10.73 -0.51 3.19e-23 Blood protein levels; CRC cis rs9914988 0.887 rs2070265 chr17:27075423 A/G cg16670446 chr17:27188758 MIR451;MIR144 -0.52 -8.54 -0.43 5.19e-16 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs11924390 0.749 rs822363 chr3:186452991 C/G cg04611788 chr3:186434169 KNG1 -0.58 -8.36 -0.42 1.79e-15 Adiponectin levels; CRC cis rs6121246 0.779 rs6060763 chr20:30282223 A/G cg18721089 chr20:30220636 NA -0.36 -6.06 -0.32 3.71e-9 Mean corpuscular hemoglobin; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg14750263 chr11:10324369 NA 0.41 5.96 0.31 6.36e-9 Intelligence (multi-trait analysis); CRC cis rs763014 1.000 rs7205409 chr16:642610 A/G cg08989290 chr16:615782 NHLRC4 0.43 8.26 0.41 3.56e-15 Height; CRC trans rs208520 1.000 rs12190773 chr6:66968194 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.89 11.02 0.52 2.96e-24 Exhaled nitric oxide output; CRC cis rs2115630 0.645 rs2292463 chr15:85175750 A/G cg17507749 chr15:85114479 UBE2QP1 -0.39 -5.88 -0.31 1.01e-8 P wave terminal force; CRC cis rs6545883 0.965 rs3771261 chr2:61762161 A/G cg15711740 chr2:61764176 XPO1 -0.52 -7.13 -0.37 6.43e-12 Tuberculosis; CRC cis rs10979 1.000 rs13198159 chr6:143891953 C/T cg25407410 chr6:143891975 LOC285740 -0.83 -13.43 -0.6 4.27e-33 Hypospadias; CRC cis rs9911578 0.933 rs74370218 chr17:57095212 C/T cg12560992 chr17:57184187 TRIM37 -0.94 -17.88 -0.7 2e-50 Intelligence (multi-trait analysis); CRC trans rs7395662 1.000 rs4882123 chr11:48575739 G/A cg21153622 chr11:89784906 NA -0.44 -7.1 -0.36 7.56e-12 HDL cholesterol; CRC cis rs4665809 1.000 rs4665819 chr2:26309073 A/G cg27170947 chr2:26402098 FAM59B -0.45 -6.06 -0.32 3.68e-9 Gut microbiome composition (summer); CRC trans rs916888 0.773 rs169201 chr17:44790203 A/G cg22433210 chr17:43662623 NA 1.02 10.37 0.5 5.29e-22 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs9868809 0.505 rs56735597 chr3:48765168 A/G cg07636037 chr3:49044803 WDR6 -0.7 -6.29 -0.33 1.03e-9 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; CRC trans rs66759488 0.739 rs10851451 chr15:47608991 A/G cg02228815 chr15:31685131 NA -0.43 -5.98 -0.31 5.89e-9 Lung cancer; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg03087334 chr18:33077969 INO80C 0.48 6.18 0.32 1.87e-9 Thyroid stimulating hormone; CRC cis rs4731207 0.535 rs1552120 chr7:124639238 A/G cg23710748 chr7:124431027 NA -0.38 -6.08 -0.32 3.27e-9 Cutaneous malignant melanoma; CRC cis rs9611565 0.729 rs73176689 chr22:41782633 T/C cg06634786 chr22:41940651 POLR3H -0.67 -7.67 -0.39 1.98e-13 Vitiligo; CRC cis rs11809207 0.523 rs2802343 chr1:26498570 T/C cg24519413 chr1:26490540 NA 0.38 6.35 0.33 7.05e-10 Height; CRC cis rs270601 0.721 rs270621 chr5:131605821 C/A cg20512303 chr5:131592959 PDLIM4 0.41 7.12 0.37 7e-12 Acylcarnitine levels; CRC cis rs62244186 0.627 rs12386385 chr3:44457540 A/G cg10263370 chr3:44754102 ZNF502 -0.36 -5.86 -0.31 1.09e-8 Depressive symptoms; CRC cis rs477895 1.000 rs7947143 chr11:64090422 G/A cg04317338 chr11:64019027 PLCB3 0.61 5.98 0.31 5.71e-9 Mean platelet volume; CRC cis rs637571 0.522 rs538954 chr11:65756808 A/G cg26695010 chr11:65641043 EFEMP2 -0.4 -6.12 -0.32 2.67e-9 Eosinophil percentage of white cells; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg06096824 chr1:51443952 NA 0.36 5.97 0.31 6.1e-9 Liver disease severity in Alagille syndrome; CRC cis rs9467711 0.591 rs35169013 chr6:25918027 A/C cg16898833 chr6:26189333 HIST1H4D 0.76 6.58 0.34 1.89e-10 Autism spectrum disorder or schizophrenia; CRC trans rs11098499 0.909 rs28632018 chr4:120386730 T/C cg25214090 chr10:38739885 LOC399744 0.66 10.55 0.5 1.36e-22 Corneal astigmatism; CRC trans rs17685 0.753 rs1104879 chr7:75685568 C/T cg19862616 chr7:65841803 NCRNA00174 0.98 18.38 0.71 2.05e-52 Coffee consumption;Coffee consumption (cups per day); CRC cis rs60871478 1.000 rs4721124 chr7:823761 T/C cg05535760 chr7:792225 HEATR2 0.82 11.06 0.52 2.2e-24 Cerebrospinal P-tau181p levels; CRC cis rs7487075 0.578 rs2897951 chr12:46809206 G/A cg22049899 chr12:47219821 SLC38A4 0.31 5.67 0.3 3.17e-8 Itch intensity from mosquito bite; CRC trans rs2832077 0.943 rs11702320 chr21:30195251 A/T cg14791747 chr16:20752902 THUMPD1 0.52 6.36 0.33 6.59e-10 Cognitive test performance; CRC cis rs1728785 0.688 rs698729 chr16:68624205 G/C cg02972257 chr16:68554789 NA -0.56 -6.99 -0.36 1.51e-11 Ulcerative colitis; CRC cis rs2976388 0.590 rs13254346 chr8:143823863 G/C cg15511327 chr8:143859410 LYNX1 -0.39 -6.52 -0.34 2.65e-10 Urinary tract infection frequency; CRC cis rs4909189 1.000 rs71547530 chr7:158135503 A/G cg06219351 chr7:158114137 PTPRN2 -0.6 -8.14 -0.41 8.09e-15 Response to amphetamines; CRC cis rs6504622 0.905 rs9889741 chr17:45026333 G/A cg16759221 chr17:45003025 GOSR2 -0.52 -8.3 -0.42 2.69e-15 Orofacial clefts; CRC cis rs7216064 1.000 rs62085992 chr17:65923083 T/A cg12091567 chr17:66097778 LOC651250 -0.67 -7.64 -0.39 2.44e-13 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CRC cis rs2153535 0.580 rs915350 chr6:8443486 A/G cg07606381 chr6:8435919 SLC35B3 0.68 10.93 0.52 6.24e-24 Motion sickness; CRC cis rs2576037 0.562 rs612519 chr18:44379490 G/A cg23996704 chr18:44553084 KATNAL2 -0.31 -6.17 -0.32 1.98e-9 Personality dimensions; CRC cis rs977987 0.778 rs2113232 chr16:75391185 T/C cg03315344 chr16:75512273 CHST6 0.53 8.81 0.44 7.17e-17 Dupuytren's disease; CRC cis rs1862618 0.671 rs906631 chr5:56245803 C/G cg03609598 chr5:56110824 MAP3K1 0.59 7.99 0.4 2.34e-14 Initial pursuit acceleration; CRC cis rs6840360 0.530 rs62327350 chr4:152641202 G/A cg09659197 chr4:152720779 NA 0.32 5.77 0.3 1.8e-8 Intelligence (multi-trait analysis); CRC cis rs514406 0.858 rs574853 chr1:53310959 A/T cg24675658 chr1:53192096 ZYG11B -0.58 -8.71 -0.43 1.49e-16 Monocyte count; CRC cis rs7586879 0.658 rs7563204 chr2:25125075 T/G cg04586622 chr2:25135609 ADCY3 -0.55 -10.22 -0.49 1.81e-21 Body mass index; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg12445461 chr9:6681608 NA 0.54 7.13 0.37 6.23e-12 Thyroid stimulating hormone; CRC cis rs1580019 0.961 rs1868777 chr7:32494076 C/T cg06627557 chr7:32535165 LSM5;AVL9 0.64 10.09 0.49 4.73e-21 Cognitive ability; CRC cis rs4713118 0.513 rs149941 chr6:28001033 T/C cg15845792 chr6:28175446 NA 0.75 11.09 0.52 1.64e-24 Parkinson's disease; CRC cis rs9914988 0.887 rs4795464 chr17:27146497 G/C cg16670446 chr17:27188758 MIR451;MIR144 0.53 8.4 0.42 1.32e-15 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs1552244 0.572 rs59132826 chr3:10169725 G/A cg13047869 chr3:10149882 C3orf24 0.53 6.49 0.34 3.25e-10 Alzheimer's disease; CRC cis rs853679 0.824 rs1321505 chr6:28052823 A/C cg15786705 chr6:28176104 NA 0.7 5.88 0.31 1e-8 Depression; CRC cis rs9487051 0.676 rs9398193 chr6:109593134 G/T cg01475377 chr6:109611718 NA -0.37 -6.58 -0.34 1.85e-10 Reticulocyte fraction of red cells; CRC cis rs2243480 1.000 rs57057549 chr7:65405738 A/G cg12463550 chr7:65579703 CRCP 0.66 6.19 0.32 1.79e-9 Diabetic kidney disease; CRC cis rs34779708 0.733 rs12254018 chr10:35550641 T/A cg03585969 chr10:35415529 CREM 0.5 6.49 0.34 3.17e-10 Inflammatory bowel disease;Crohn's disease; CRC cis rs10788264 0.569 rs7089468 chr10:124019052 T/C cg09507567 chr10:124027408 NA 0.34 7.41 0.38 1.1e-12 Total body bone mineral density; CRC cis rs73195822 0.667 rs7967386 chr12:111239162 G/A cg12870014 chr12:110450643 ANKRD13A 0.58 5.92 0.31 8.15e-9 Itch intensity from mosquito bite; CRC cis rs6952808 0.929 rs2280546 chr7:1976863 G/A cg21782813 chr7:2030301 MAD1L1 0.48 7.85 0.4 6.04e-14 Bipolar disorder and schizophrenia; CRC cis rs17711722 0.740 rs7809991 chr7:65406218 A/G cg05627663 chr7:65219948 SNORA22;CCT6P1 0.49 7.24 0.37 3.14e-12 Calcium levels; CRC trans rs9561329 0.800 rs1408208 chr13:94034934 G/A cg23072629 chr2:239195537 PER2 0.32 6.01 0.31 5.03e-9 Neuroticism (age interaction); CRC cis rs4665809 0.556 rs4665322 chr2:26434605 C/G cg08067268 chr2:26466485 HADHB;HADHA -0.65 -8.54 -0.43 5.12e-16 Gut microbiome composition (summer); CRC cis rs4964805 0.954 rs10861105 chr12:104189999 C/T cg02344784 chr12:104178138 NT5DC3 0.56 8.5 0.42 6.72e-16 Attention deficit hyperactivity disorder; CRC cis rs6977955 1.000 rs4722760 chr7:28172183 C/T cg23620719 chr7:28220237 JAZF1 -0.43 -5.61 -0.3 4.4e-8 Allergic disease (asthma, hay fever or eczema); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg08580838 chr8:104427696 DCAF13;SLC25A32 0.38 5.98 0.31 5.82e-9 Liver disease severity in Alagille syndrome; CRC trans rs6546324 0.580 rs6724133 chr2:67858671 A/G cg00907274 chr3:27498161 SLC4A7 -0.49 -6.23 -0.32 1.44e-9 Endometriosis; CRC cis rs55788414 0.932 rs34110030 chr16:81185211 G/A cg06400318 chr16:81190750 PKD1L2 -0.6 -6.87 -0.35 3.27e-11 Left ventricular obstructive tract defect (maternal effect); CRC cis rs4954585 0.683 rs4072434 chr2:137014023 C/G cg05194412 chr2:137003533 NA 0.44 6.89 0.35 2.9e-11 Colorectal cancer; CRC trans rs208520 0.954 rs72884027 chr6:66995044 T/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.91 11.06 0.52 2.21e-24 Exhaled nitric oxide output; CRC cis rs897984 0.568 rs72799330 chr16:30893555 C/A cg02466173 chr16:30829666 NA -0.71 -9.12 -0.45 7.86e-18 Dementia with Lewy bodies; CRC cis rs4975616 0.839 rs2447853 chr5:1333077 A/G cg26373071 chr5:1325741 CLPTM1L 0.55 9.95 0.48 1.4e-20 Lung cancer; CRC cis rs7703744 0.634 rs17145248 chr5:118685011 C/T cg02283238 chr5:118691126 TNFAIP8 0.46 6.15 0.32 2.18e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs1887596 0.705 rs1697223 chr13:27216940 A/T cg01312412 chr13:27282625 NA -0.42 -5.85 -0.31 1.2e-8 Facial morphology (factor 3, length of philtrum); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg08377569 chr16:30538014 ZNF768 0.38 6.47 0.34 3.47e-10 Liver disease severity in Alagille syndrome; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg06814637 chr1:36554277 ADPRHL2 0.42 6.0 0.31 5.2e-9 Intelligence (multi-trait analysis); CRC cis rs60871478 0.898 rs4720929 chr7:808009 T/C cg13844804 chr7:814759 HEATR2 0.65 8.51 0.42 6.2e-16 Cerebrospinal P-tau181p levels; CRC cis rs7428 1.000 rs72840063 chr2:85550396 T/A cg24342717 chr2:85555507 TGOLN2 -0.5 -6.93 -0.36 2.29e-11 Ear protrusion; CRC cis rs172166 0.561 rs149971 chr6:27982152 G/A cg25164649 chr6:28176230 NA 0.48 6.96 0.36 1.88e-11 Cardiac Troponin-T levels; CRC cis rs6502050 0.835 rs10163485 chr17:80110750 C/T cg25804541 chr17:80189381 SLC16A3 -0.31 -5.97 -0.31 6.08e-9 Life satisfaction; CRC cis rs758324 0.812 rs10045303 chr5:131202801 C/T cg25547332 chr5:131281432 NA -0.36 -5.7 -0.3 2.61e-8 Alzheimer's disease in APOE e4- carriers; CRC cis rs9463078 0.838 rs1924662 chr6:45140332 T/A cg25276700 chr6:44698697 NA -0.29 -6.82 -0.35 4.28e-11 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; CRC cis rs3785574 0.962 rs2665840 chr17:61873307 C/T cg23090583 chr17:61904693 PSMC5;FTSJ3 -0.65 -9.56 -0.47 2.82e-19 Height; CRC cis rs6594499 0.872 rs10045255 chr5:110438357 C/T cg04022379 chr5:110408740 TSLP -0.49 -7.55 -0.38 4.41e-13 Allergic disease (asthma, hay fever or eczema); CRC cis rs2836974 0.863 rs8132333 chr21:40527900 A/G cg06238570 chr21:40685208 BRWD1 0.71 10.02 0.48 8.55e-21 Cognitive function; CRC cis rs10504229 1.000 rs67188507 chr8:58187492 A/T cg05313129 chr8:58192883 C8orf71 -0.47 -6.99 -0.36 1.49e-11 Developmental language disorder (linguistic errors); CRC cis rs7568498 0.564 rs10490563 chr2:161914168 G/A cg08807892 chr2:162101083 NA -0.43 -5.67 -0.3 3.16e-8 Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 3 peripheral neuropathy); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg06886078 chr10:126480477 METTL10 0.37 6.39 0.33 5.74e-10 Liver disease severity in Alagille syndrome; CRC cis rs9786986 0.764 rs210036 chr1:235694741 C/T cg08848088 chr1:235714526 GNG4 0.49 5.76 0.3 1.94e-8 Body mass index; CRC cis rs1862618 0.853 rs832553 chr5:56114786 A/G cg22800045 chr5:56110881 MAP3K1 0.55 6.11 0.32 2.79e-9 Initial pursuit acceleration; CRC cis rs2000999 0.515 rs2854956 chr16:72115238 A/T cg01557791 chr16:72042693 DHODH -0.5 -7.03 -0.36 1.23e-11 Total cholesterol levels;Cholesterol, total;Blood protein levels;LDL cholesterol levels;Haptoglobin levels;LDL cholesterol; CRC cis rs10504229 0.683 rs903706 chr8:58128134 T/G cg24829409 chr8:58192753 C8orf71 -0.55 -8.03 -0.4 1.71e-14 Developmental language disorder (linguistic errors); CRC cis rs3796352 1.000 rs11713290 chr3:52971579 G/A cg07884673 chr3:53033167 SFMBT1 0.69 6.12 0.32 2.67e-9 Immune reponse to smallpox (secreted IL-2); CRC cis rs6951245 1.000 rs76214082 chr7:1102097 T/A cg18402987 chr7:1209562 NA 0.67 7.17 0.37 5.02e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs9733 0.596 rs72702552 chr1:150677462 G/A cg18016565 chr1:150552671 MCL1 0.46 6.7 0.35 9.26e-11 Tonsillectomy; CRC cis rs2549003 1.000 rs7735073 chr5:131815357 G/A cg21138405 chr5:131827807 IRF1 0.57 11.37 0.53 1.67e-25 Asthma (sex interaction); CRC cis rs3008870 1.000 rs17497828 chr1:67452322 G/A cg08660285 chr1:67390436 MIER1;WDR78 -1.01 -13.97 -0.61 3.74e-35 Lymphocyte percentage of white cells; CRC cis rs2456568 0.564 rs4608039 chr11:93624799 C/G cg26875233 chr11:93583750 C11orf90 0.37 7.17 0.37 4.82e-12 Response to serotonin reuptake inhibitors in major depressive disorder; CRC cis rs6502050 0.667 rs9892469 chr17:80093657 T/C cg13198984 chr17:80129470 CCDC57 0.46 8.15 0.41 7.78e-15 Life satisfaction; CRC cis rs561341 0.941 rs550213 chr17:30317518 C/G cg23018236 chr17:30244563 NA -0.58 -7.7 -0.39 1.64e-13 Hip circumference adjusted for BMI; CRC trans rs7615952 0.932 rs1976458 chr3:125647512 T/G cg02560186 chr11:3602584 NA -0.47 -6.3 -0.33 9.55e-10 Blood pressure (smoking interaction); CRC cis rs57221529 0.766 rs17563576 chr5:560476 A/G cg17948913 chr5:572064 NA 0.51 6.14 0.32 2.43e-9 Lung disease severity in cystic fibrosis; CRC cis rs78456975 1.000 rs13429866 chr2:1555211 C/A cg01028140 chr2:1542097 TPO -0.56 -5.73 -0.3 2.25e-8 Placebo response in major depressive disorder (% change in symptom score); CRC cis rs875971 0.862 rs2088653 chr7:65808608 G/A cg12463550 chr7:65579703 CRCP -0.5 -6.8 -0.35 4.92e-11 Aortic root size; CRC cis rs4713118 0.662 rs149900 chr6:28014597 C/T cg25164649 chr6:28176230 NA 0.63 8.31 0.42 2.62e-15 Parkinson's disease; CRC cis rs600806 0.815 rs10858089 chr1:109926828 T/C cg23032129 chr1:109941072 SORT1 -0.28 -6.06 -0.32 3.68e-9 Intelligence (multi-trait analysis); CRC cis rs12144309 0.554 rs1217375 chr1:114346904 G/A cg03325407 chr1:114423726 BCL2L15 0.35 6.52 0.34 2.63e-10 Coronary artery disease; CRC cis rs870825 0.581 rs7675106 chr4:185652388 C/G cg04058563 chr4:185651563 MLF1IP -0.69 -8.69 -0.43 1.68e-16 Blood protein levels; CRC cis rs539514 0.690 rs4885345 chr13:76318453 C/T cg04757411 chr13:76259545 LMO7 0.35 5.95 0.31 6.73e-9 Type 1 diabetes; CRC cis rs2836974 0.897 rs36113648 chr21:40555497 G/A cg11644478 chr21:40555479 PSMG1 0.84 13.39 0.59 6.15e-33 Cognitive function; CRC cis rs56114371 0.530 rs169262 chr6:27770890 C/T cg06470822 chr6:28175283 NA 0.58 6.84 0.35 3.81e-11 Breast cancer; CRC cis rs9847710 0.967 rs2564934 chr3:53024580 G/A cg18404041 chr3:52824283 ITIH1 0.3 5.94 0.31 7.34e-9 Ulcerative colitis; CRC cis rs2295359 0.824 rs11209003 chr1:67601132 G/T cg03340356 chr1:67600835 NA 0.32 6.96 0.36 1.81e-11 Psoriasis; CRC cis rs1448094 0.967 rs10746357 chr12:86341044 A/T cg19622623 chr12:86230825 RASSF9 -0.36 -5.9 -0.31 8.85e-9 Major depressive disorder; CRC cis rs6964587 0.900 rs6465352 chr7:91775117 A/G cg17063962 chr7:91808500 NA 0.84 14.85 0.63 1.52e-38 Breast cancer; CRC cis rs875971 0.660 rs801217 chr7:66010577 C/T cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.43 -6.44 -0.33 4.21e-10 Aortic root size; CRC trans rs11026407 0.967 rs7127246 chr11:22060228 C/G cg20467896 chr19:6361623 CLPP -0.55 -5.97 -0.31 6e-9 Plasma thyroid-stimulating hormone levels; CRC cis rs9733 0.596 rs72702570 chr1:150688196 C/T cg10589385 chr1:150898437 SETDB1 0.28 5.96 0.31 6.66e-9 Tonsillectomy; CRC cis rs56283067 0.847 rs56172130 chr6:44696262 G/A cg18551225 chr6:44695536 NA -0.41 -6.04 -0.32 4.17e-9 Total body bone mineral density; CRC cis rs939584 0.696 rs62105306 chr2:633660 C/T cg03610516 chr2:642275 NA 0.42 5.65 0.3 3.49e-8 Body mass index; CRC cis rs9393692 0.875 rs12526215 chr6:26262916 T/C cg13736514 chr6:26305472 NA -0.61 -11.27 -0.53 3.78e-25 Educational attainment; CRC cis rs1008375 1.000 rs10939756 chr4:17693867 C/T cg16339924 chr4:17578868 LAP3 0.47 6.31 0.33 8.84e-10 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs4665809 1.000 rs1470097 chr2:26312840 A/G cg25036284 chr2:26402008 FAM59B -0.46 -6.15 -0.32 2.27e-9 Gut microbiome composition (summer); CRC cis rs10208940 0.841 rs10172125 chr2:68787191 T/G cg12452813 chr2:68675892 NA 0.47 5.93 0.31 7.57e-9 Urate levels in lean individuals; CRC cis rs6456156 0.805 rs6909252 chr6:167527097 C/T cg05540913 chr6:167530185 CCR6 -0.41 -7.36 -0.38 1.44e-12 Primary biliary cholangitis; CRC cis rs798554 0.757 rs1182176 chr7:2874601 A/G cg19717773 chr7:2847554 GNA12 -0.44 -6.59 -0.34 1.71e-10 Height; CRC trans rs9747201 1.000 rs12451470 chr17:80177532 G/A cg07393940 chr7:158741817 NA 0.51 7.22 0.37 3.52e-12 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs9747201 0.862 rs57596657 chr17:80147978 C/T cg09264619 chr17:80180166 NA -0.5 -7.28 -0.37 2.49e-12 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs727505 1.000 rs10264060 chr7:124486413 C/A cg23710748 chr7:124431027 NA -0.79 -14.18 -0.62 6.07e-36 Lewy body disease; CRC cis rs9486719 0.947 rs2472893 chr6:96870048 G/C cg06623918 chr6:96969491 KIAA0776 0.81 9.48 0.46 5.18e-19 Migraine;Coronary artery disease; CRC cis rs2075371 0.966 rs2544224 chr7:133995832 A/G cg02659138 chr7:134003124 SLC35B4 0.43 7.49 0.38 6.58e-13 Mean platelet volume; CRC cis rs6484504 0.625 rs7940420 chr11:31366700 T/A cg14844989 chr11:31128820 NA 0.33 5.73 0.3 2.22e-8 Red blood cell count; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg24155668 chr6:36098398 MAPK13 0.43 6.13 0.32 2.46e-9 Response to antipsychotic treatment; CRC cis rs1153858 0.945 rs1974981 chr15:45729123 C/T cg10760299 chr15:45669010 GATM -0.44 -6.82 -0.35 4.48e-11 Homoarginine levels; CRC cis rs6969780 1.000 rs6461985 chr7:27150634 T/C cg26364809 chr7:27145159 NA -0.72 -6.71 -0.35 8.56e-11 Diastolic blood pressure;Blood pressure traits (multi-trait analysis);Systolic blood pressure;Hypertension; CRC cis rs10540 1.000 rs12801148 chr11:511707 T/G cg15790184 chr11:494944 RNH1 0.61 6.24 0.33 1.35e-9 Body mass index; CRC cis rs78761021 0.514 rs4791906 chr17:9795452 A/G cg26853458 chr17:9805074 RCVRN -0.28 -6.01 -0.31 5e-9 Type 2 diabetes; CRC cis rs10504229 1.000 rs111915672 chr8:58191665 T/C cg05313129 chr8:58192883 C8orf71 -0.46 -6.71 -0.35 8.67e-11 Developmental language disorder (linguistic errors); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg10130860 chr1:43124230 PPIH 0.44 6.54 0.34 2.35e-10 Intelligence (multi-trait analysis); CRC cis rs6479527 0.875 rs4744308 chr9:96798762 C/T cg14459158 chr9:96720562 NA 0.38 6.71 0.35 8.37e-11 Esophageal adenocarcinoma; CRC cis rs459571 0.959 rs416390 chr9:136908549 C/G cg13789015 chr9:136890014 NCRNA00094 -0.43 -5.74 -0.3 2.21e-8 Platelet distribution width; CRC cis rs3733585 0.648 rs13103497 chr4:9979262 A/G cg11266682 chr4:10021025 SLC2A9 0.46 9.21 0.45 3.9e-18 Cleft plate (environmental tobacco smoke interaction); CRC cis rs9814567 1.000 rs10935120 chr3:134233092 C/T cg06541857 chr3:134203789 ANAPC13;CEP63 0.38 5.67 0.3 3.1e-8 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs9393692 0.620 rs6908402 chr6:26293014 A/T cg13736514 chr6:26305472 NA -0.46 -7.67 -0.39 1.95e-13 Educational attainment; CRC cis rs2898681 0.519 rs6554057 chr4:53730147 A/T cg26260408 chr4:53727979 RASL11B 0.41 5.86 0.31 1.12e-8 Optic nerve measurement (cup area); CRC cis rs10751667 0.961 rs7396670 chr11:929269 A/G ch.11.42038R chr11:967971 AP2A2 0.72 12.01 0.55 8.26e-28 Alzheimer's disease (late onset); CRC cis rs10504229 0.683 rs1495866 chr8:58141128 T/C cg02290350 chr8:58132656 NA -0.58 -8.16 -0.41 7.29e-15 Developmental language disorder (linguistic errors); CRC cis rs2799081 1 rs2799081 chr6:28270584 T/C cg03623178 chr6:28175578 NA 0.48 6.37 0.33 6.37e-10 Myopia; CRC cis rs10484885 0.887 rs17764308 chr6:90602268 T/C cg13799429 chr6:90582589 CASP8AP2 -0.72 -8.41 -0.42 1.25e-15 QRS interval (sulfonylurea treatment interaction); CRC cis rs4974559 0.790 rs6850727 chr4:1323273 G/C cg02980000 chr4:1222292 CTBP1 0.5 6.36 0.33 6.68e-10 Systolic blood pressure; CRC cis rs12048904 0.505 rs11166511 chr1:101240686 G/C cg15686842 chr1:101360669 SLC30A7;EXTL2 -0.56 -7.46 -0.38 7.53e-13 Multiple sclerosis; CRC cis rs1178968 1.000 rs4717751 chr7:72750627 G/A cg25889504 chr7:72793014 NA 0.53 6.04 0.32 4.16e-9 Triglyceride levels; CRC cis rs1046896 0.552 rs12602280 chr17:80805421 G/C cg17346650 chr17:80929145 B3GNTL1 0.49 7.12 0.37 6.93e-12 Glycated hemoglobin levels; CRC cis rs739401 0.572 rs7111857 chr11:3068106 A/G cg08508325 chr11:3079039 CARS 0.5 9.13 0.45 6.91e-18 Longevity; CRC cis rs4253772 0.550 rs6007830 chr22:46711323 C/T cg03482458 chr22:46692211 CN5H6.4;GTSE1 0.51 6.02 0.31 4.74e-9 LDL cholesterol;Cholesterol, total; CRC cis rs2949837 0.528 rs10260816 chr7:46010100 C/G cg04796162 chr7:45961102 IGFBP3 -0.43 -7.26 -0.37 2.88e-12 Sitting height ratio; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg11342046 chr2:242641489 ING5 0.46 6.03 0.32 4.32e-9 Thyroid stimulating hormone; CRC cis rs1448094 0.967 rs7301496 chr12:86321212 A/C cg02569458 chr12:86230093 RASSF9 0.37 6.46 0.34 3.67e-10 Major depressive disorder; CRC trans rs8035957 1.000 rs4924273 chr15:38846738 C/G cg01900965 chr4:2471727 RNF4 -0.51 -5.96 -0.31 6.39e-9 Type 1 diabetes; CRC cis rs561341 0.941 rs2428341 chr17:30317295 C/T cg19193384 chr17:30244184 NA -0.49 -6.75 -0.35 6.88e-11 Hip circumference adjusted for BMI; CRC cis rs939658 1.000 rs8033963 chr15:79455350 C/T cg17916960 chr15:79447300 NA 0.45 7.4 0.38 1.14e-12 Refractive error; CRC cis rs7312933 0.584 rs7974654 chr12:42630466 C/A cg19980929 chr12:42632907 YAF2 0.48 7.3 0.37 2.16e-12 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CRC cis rs1448094 0.617 rs10863162 chr12:86474122 C/T cg02569458 chr12:86230093 RASSF9 -0.42 -7.12 -0.37 6.98e-12 Major depressive disorder; CRC cis rs6502050 0.835 rs4523985 chr17:80154466 C/A cg19223190 chr17:80058835 NA 0.41 6.5 0.34 3e-10 Life satisfaction; CRC cis rs11190604 1.000 rs11190589 chr10:102275471 A/G cg07080220 chr10:102295463 HIF1AN 0.46 5.73 0.3 2.27e-8 Palmitoleic acid (16:1n-7) levels; CRC cis rs9302635 0.513 rs7198572 chr16:72183220 G/A cg23815491 chr16:72088622 HP 0.64 8.0 0.4 2.15e-14 Blood protein levels; CRC trans rs208520 0.609 rs208436 chr6:66897470 G/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.66 -9.21 -0.45 3.94e-18 Exhaled nitric oxide output; CRC cis rs11758351 0.660 rs11755943 chr6:26211368 A/G cg21425842 chr6:26240939 HIST1H4F -0.34 -5.72 -0.3 2.45e-8 Gout;Renal underexcretion gout; CRC cis rs597539 0.652 rs667989 chr11:68685776 T/A cg21963583 chr11:68658836 MRPL21 0.59 10.44 0.5 3.1e-22 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs4803468 0.967 rs3745290 chr19:41890003 C/T cg09537434 chr19:41945824 ATP5SL -0.91 -17.75 -0.7 6.67e-50 Height; CRC cis rs2859741 0.967 rs507460 chr1:37493206 C/G cg09363841 chr1:37513479 NA 0.61 11.29 0.53 3.27e-25 Forced expiratory volume in 1 second (environmental tobacco smoke interaction); CRC cis rs9463078 0.753 rs10948186 chr6:44903248 C/T cg25276700 chr6:44698697 NA -0.28 -6.74 -0.35 7.27e-11 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; CRC cis rs2933343 0.729 rs789228 chr3:128601050 A/G cg25356066 chr3:128598488 ACAD9 0.39 5.67 0.3 3.06e-8 IgG glycosylation; CRC cis rs12983728 1.000 rs12983728 chr19:58671267 G/A cg21294424 chr19:58662284 ZNF329 0.83 9.28 0.46 2.31e-18 Cholesterol, total; CRC cis rs4938330 0.723 rs7931398 chr11:116879676 T/C cg20608306 chr11:116969690 SIK3 -0.31 -5.9 -0.31 8.8e-9 Blood protein levels; CRC cis rs2976388 0.609 rs2257796 chr8:143808667 T/C cg24046110 chr8:143859143 LYNX1 0.49 8.52 0.43 5.77e-16 Urinary tract infection frequency; CRC cis rs7223966 1.000 rs1877316 chr17:61766880 C/A cg23090583 chr17:61904693 PSMC5;FTSJ3 0.5 6.19 0.32 1.75e-9 Hip circumference adjusted for BMI;Body mass index; CRC cis rs7264396 0.570 rs6060717 chr20:34544647 T/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.6 -9.71 -0.47 9.15e-20 Total cholesterol levels; CRC cis rs6952808 0.609 rs12699453 chr7:1953056 C/T cg04267008 chr7:1944627 MAD1L1 -0.67 -10.42 -0.5 3.58e-22 Bipolar disorder and schizophrenia; CRC cis rs9303401 0.614 rs34900851 chr17:56566399 G/A cg02118635 chr17:56770003 RAD51C;TEX14 0.77 9.58 0.47 2.52e-19 Cognitive test performance; CRC cis rs6840360 0.593 rs4696107 chr4:152606823 G/A cg09659197 chr4:152720779 NA 0.4 7.93 0.4 3.4e-14 Intelligence (multi-trait analysis); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G ch.5.67026991F chr5:66991235 NA 0.4 5.99 0.31 5.53e-9 Liver disease severity in Alagille syndrome; CRC cis rs6964587 1.000 rs2106171 chr7:91750450 A/G cg17063962 chr7:91808500 NA 0.83 14.72 0.63 5.16e-38 Breast cancer; CRC cis rs7224314 1.000 rs62085808 chr17:65357692 G/A cg01507342 chr17:65387096 PITPNC1 -0.42 -5.71 -0.3 2.5e-8 Diisocyanate-induced asthma; CRC cis rs55702914 0.809 rs6738721 chr2:198182334 A/G cg03934865 chr2:198174659 NA -0.41 -7.11 -0.36 7.41e-12 Major depression and alcohol dependence; CRC cis rs1008375 1.000 rs6849704 chr4:17652031 G/C cg02297831 chr4:17616191 MED28 0.44 5.92 0.31 8.19e-9 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs2463822 0.688 rs7121684 chr11:62162389 T/C cg06239285 chr11:62104954 ASRGL1 -0.94 -9.7 -0.47 1.01e-19 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs7618915 0.547 rs6976 chr3:52728804 C/T cg18099408 chr3:52552593 STAB1 -0.46 -7.32 -0.37 1.87e-12 Bipolar disorder; CRC cis rs888194 0.544 rs7316486 chr12:109849540 A/G cg19025524 chr12:109796872 NA -0.49 -7.37 -0.38 1.36e-12 Neuroticism; CRC cis rs17443541 0.564 rs1450570 chr2:200442061 G/T cg03741458 chr2:200468445 NA 0.37 5.81 0.31 1.47e-8 Intelligence (multi-trait analysis); CRC cis rs6495122 0.501 rs6495151 chr15:75385990 A/G cg17294928 chr15:75287854 SCAMP5 -0.42 -6.4 -0.33 5.39e-10 Caffeine consumption;Diastolic blood pressure;Coffee consumption; CRC cis rs2976388 0.556 rs10956985 chr8:143818750 C/A cg10596483 chr8:143751796 JRK -0.5 -6.82 -0.35 4.5e-11 Urinary tract infection frequency; CRC trans rs7267979 1.000 rs6115146 chr20:25304507 G/A cg17903999 chr18:56338584 MALT1 0.42 7.05 0.36 1.08e-11 Liver enzyme levels (alkaline phosphatase); CRC cis rs7618915 0.547 rs6976 chr3:52728804 C/T cg18404041 chr3:52824283 ITIH1 -0.42 -8.46 -0.42 9.03e-16 Bipolar disorder; CRC trans rs2727020 0.553 rs4980447 chr11:49591662 T/C cg03929089 chr4:120376271 NA -0.76 -10.35 -0.5 6.54e-22 Coronary artery disease; CRC trans rs58810682 0.662 rs12164144 chr8:43701112 C/T cg20651681 chr7:50861418 GRB10 -0.46 -5.99 -0.31 5.37e-9 Response to amphetamines; CRC cis rs2032447 0.933 rs4401650 chr6:26035208 G/A cg04800585 chr6:26043546 HIST1H2BB 0.56 8.36 0.42 1.84e-15 Intelligence (multi-trait analysis); CRC cis rs7914558 1.000 rs10786740 chr10:104935593 G/C cg15744005 chr10:104629667 AS3MT -0.34 -7.32 -0.37 1.97e-12 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg17520203 chr4:47465732 COMMD8 0.44 6.16 0.32 2.12e-9 Response to antipsychotic treatment; CRC cis rs7044106 0.791 rs4837792 chr9:123483559 G/A cg14255062 chr9:123606675 PSMD5;LOC253039 0.48 7.24 0.37 3.19e-12 Hip circumference adjusted for BMI; CRC cis rs478304 0.934 rs537786 chr11:65494987 C/T cg27068330 chr11:65405492 SIPA1 0.45 6.69 0.35 9.62e-11 Acne (severe); CRC trans rs9467711 0.606 rs9379875 chr6:26444732 C/T cg06606381 chr12:133084897 FBRSL1 -0.85 -6.39 -0.33 5.62e-10 Autism spectrum disorder or schizophrenia; CRC trans rs116095464 0.558 rs2288458 chr5:231260 C/T cg00938859 chr5:1591904 SDHAP3 0.72 7.88 0.4 4.89e-14 Breast cancer; CRC cis rs13191362 0.935 rs7769048 chr6:163010040 T/A cg21926612 chr6:163149169 PACRG;PARK2 0.78 10.8 0.51 1.77e-23 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs394563 0.591 rs237019 chr6:149727064 G/A cg11245181 chr6:149772854 ZC3H12D -0.53 -9.29 -0.46 2.11e-18 Dupuytren's disease; CRC cis rs4588572 0.643 rs7701154 chr5:77716621 G/A cg11547950 chr5:77652471 NA -0.53 -7.25 -0.37 2.96e-12 Triglycerides; CRC cis rs10751667 0.600 rs4076915 chr11:1012464 C/G ch.11.42038R chr11:967971 AP2A2 0.58 9.18 0.45 5.03e-18 Alzheimer's disease (late onset); CRC cis rs12519773 0.526 rs4242240 chr5:92517203 A/G cg18783429 chr5:92414398 NA 0.26 5.62 0.3 4.07e-8 Migraine; CRC cis rs8177253 1.000 rs8177271 chr3:133482230 G/A cg24879335 chr3:133465180 TF 0.31 5.67 0.3 3.11e-8 Iron status biomarkers; CRC cis rs1552244 1.000 rs68045038 chr3:10151828 A/G cg00166722 chr3:10149974 C3orf24 0.7 9.21 0.45 3.89e-18 Alzheimer's disease; CRC trans rs1005277 0.541 rs2472177 chr10:38384015 T/G cg11292332 chr7:45801988 SEPT13 -0.35 -6.33 -0.33 8.17e-10 Extrinsic epigenetic age acceleration; CRC cis rs4319547 0.656 rs7135419 chr12:122911861 T/A cg05707623 chr12:122985044 ZCCHC8 -0.74 -9.21 -0.45 3.87e-18 Body mass index; CRC cis rs7089973 0.604 rs17663670 chr10:116596269 A/C cg23260525 chr10:116636907 FAM160B1 -0.36 -8.39 -0.42 1.5e-15 Bipolar disorder or attention deficit hyperactivity disorder; CRC cis rs7255436 0.965 rs11666003 chr19:8452102 G/A cg16745616 chr19:8428856 ANGPTL4 -0.45 -7.04 -0.36 1.13e-11 HDL cholesterol; CRC cis rs9814567 0.752 rs4306899 chr3:134334513 G/A cg06109529 chr3:134205091 CEP63;ANAPC13 0.68 9.75 0.47 6.73e-20 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs763014 0.966 rs4984677 chr16:671682 A/G cg18653534 chr16:772142 FAM173A -0.37 -5.84 -0.31 1.26e-8 Height; CRC cis rs2658782 0.547 rs3133454 chr11:93059019 A/C cg15737290 chr11:93063684 CCDC67 0.67 10.77 0.51 2.32e-23 Pulmonary function decline; CRC cis rs533581 0.866 rs502258 chr16:88968547 G/A cg16701003 chr16:89028210 CBFA2T3 0.44 6.49 0.34 3.1e-10 Social autistic-like traits; CRC cis rs6854137 1.000 rs6854137 chr4:169728236 T/G cg20607169 chr4:169750834 PALLD 0.39 6.09 0.32 3.14e-9 Vein graft stenosis in coronary artery bypass grafting; CRC cis rs1008375 1.000 rs4698651 chr4:17694223 A/G cg16339924 chr4:17578868 LAP3 0.47 6.4 0.33 5.38e-10 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs731174 0.797 rs586252 chr1:38155265 G/C cg06917450 chr1:38156652 C1orf109 -0.51 -7.22 -0.37 3.61e-12 Prostate cancer (SNP x SNP interaction); CRC cis rs2404602 0.716 rs17362383 chr15:76650702 A/G cg23625390 chr15:77176239 SCAPER 0.49 7.14 0.37 5.85e-12 Blood metabolite levels; CRC cis rs7617480 0.610 rs4955420 chr3:49208865 A/G cg03060546 chr3:49711283 APEH 0.51 7.86 0.4 5.64e-14 Subjective well-being (multi-trait analysis);Menarche (age at onset); CRC trans rs801193 1.000 rs4279493 chr7:66226620 C/T cg05627663 chr7:65219948 SNORA22;CCT6P1 0.41 5.98 0.31 5.94e-9 Aortic root size; CRC cis rs9488822 0.636 rs12201275 chr6:116314563 C/G cg15226275 chr6:116381976 FRK 0.29 8.27 0.41 3.3e-15 Cholesterol, total;LDL cholesterol; CRC cis rs2404602 0.692 rs10444858 chr15:76962504 T/C cg23625390 chr15:77176239 SCAPER 0.49 7.22 0.37 3.68e-12 Blood metabolite levels; CRC cis rs6089584 0.816 rs4925336 chr20:60627180 A/G cg13770153 chr20:60521292 NA -0.6 -9.19 -0.45 4.6e-18 Body mass index; CRC cis rs950169 0.959 rs12911210 chr15:84792083 A/C cg17507749 chr15:85114479 UBE2QP1 0.75 11.76 0.54 7.11e-27 Schizophrenia; CRC cis rs68170813 0.559 rs4730226 chr7:106887274 A/C cg02696742 chr7:106810147 HBP1 -0.6 -6.65 -0.34 1.25e-10 Coronary artery disease; CRC cis rs4853012 0.887 rs77148265 chr2:74339519 C/T cg05890377 chr2:74357713 NA 0.63 9.92 0.48 1.8899999999999998e-20 Gestational age at birth (maternal effect); CRC cis rs972578 1.000 rs5751404 chr22:43358737 G/T cg01576275 chr22:43409880 NA -0.45 -7.25 -0.37 3.08e-12 Mean platelet volume; CRC cis rs1218582 0.596 rs4845676 chr1:154827861 C/G cg06221963 chr1:154839813 KCNN3 -0.55 -8.81 -0.44 7.39e-17 Prostate cancer; CRC cis rs1552244 1.000 rs7622966 chr3:10139833 C/T cg00166722 chr3:10149974 C3orf24 0.63 8.78 0.44 9.09e-17 Alzheimer's disease; CRC cis rs7615952 0.599 rs12496921 chr3:125701948 C/G cg02807482 chr3:125708958 NA -0.46 -5.9 -0.31 9.13e-9 Blood pressure (smoking interaction); CRC cis rs832540 0.695 rs702686 chr5:56201350 A/G cg12311346 chr5:56204834 C5orf35 -0.58 -8.58 -0.43 3.84e-16 Coronary artery disease; CRC cis rs9443645 0.505 rs11752126 chr6:79707923 C/T cg05283184 chr6:79620031 NA -0.45 -6.45 -0.34 4.01e-10 Intelligence (multi-trait analysis); CRC cis rs72634258 0.554 rs34305100 chr1:7913029 A/G cg26816564 chr1:7831052 VAMP3 0.76 8.65 0.43 2.26e-16 Inflammatory bowel disease; CRC cis rs8060686 0.641 rs1074143 chr16:68127278 A/G cg08314208 chr16:67682810 RLTPR -0.58 -6.22 -0.32 1.53e-9 HDL cholesterol;Metabolic syndrome; CRC cis rs3820068 0.705 rs74054769 chr1:15860147 A/C cg27534772 chr1:16042836 PLEKHM2 0.43 7.21 0.37 3.93e-12 Systolic blood pressure; CRC cis rs6912958 0.702 rs6906769 chr6:88235949 T/C cg12350822 chr6:88032061 C6orf162;GJB7 -0.33 -6.37 -0.33 6.44e-10 Monocyte percentage of white cells; CRC cis rs514406 0.729 rs534070 chr1:53308858 T/G cg08859206 chr1:53392774 SCP2 -0.61 -9.73 -0.47 7.7e-20 Monocyte count; CRC cis rs6674970 1.000 rs6674970 chr1:151116279 C/T cg11822372 chr1:151115635 SEMA6C 0.56 8.18 0.41 6.18e-15 Childhood ear infection; CRC cis rs9486715 1.000 rs9398148 chr6:97063555 A/G cg06623918 chr6:96969491 KIAA0776 -0.97 -16.92 -0.68 1.24e-46 Headache; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg16157821 chr3:58419758 PDHB 0.49 6.87 0.35 3.13e-11 Response to antipsychotic treatment; CRC cis rs7208859 0.623 rs7219361 chr17:29080393 G/A cg01831904 chr17:28903510 LRRC37B2 -0.62 -6.43 -0.33 4.48e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs4563143 0.675 rs34113156 chr19:29270822 G/A cg03161606 chr19:29218774 NA 0.53 6.66 0.34 1.18e-10 Methadone dose in opioid dependence; CRC cis rs9914988 0.832 rs35033748 chr17:27179590 T/C cg20469991 chr17:27169893 C17orf63 -0.48 -5.9 -0.31 8.99e-9 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs4665809 0.887 rs28699126 chr2:26357294 C/T cg25036284 chr2:26402008 FAM59B -0.45 -6.06 -0.32 3.79e-9 Gut microbiome composition (summer); CRC cis rs8077889 0.645 rs1230393 chr17:41842592 A/G cg26893861 chr17:41843967 DUSP3 -1.21 -26.26 -0.82 9.61e-83 Triglycerides; CRC trans rs75804782 0.641 rs41264155 chr2:239342096 G/A cg01134436 chr17:81009848 B3GNTL1 0.76 7.09 0.36 8.43e-12 Morning vs. evening chronotype;Chronotype; CRC cis rs11148252 0.538 rs2296348 chr13:52710136 T/G cg00495681 chr13:53174319 NA 0.62 9.26 0.45 2.68e-18 Lewy body disease; CRC cis rs2795502 0.873 rs1891324 chr10:43399581 A/G cg20628663 chr10:43360327 NA 0.61 9.46 0.46 5.96e-19 Blood protein levels; CRC cis rs9322193 0.962 rs9322220 chr6:150104033 G/C cg00933542 chr6:150070202 PCMT1 0.28 5.63 0.3 3.86e-8 Lung cancer; CRC cis rs10492096 0.783 rs11064220 chr12:6592574 C/T cg07142400 chr12:6602447 NCAPD2;MRPL51 -0.49 -5.79 -0.3 1.65e-8 Hip geometry; CRC cis rs12523822 0.957 rs9479915 chr6:154960735 T/G cg20019720 chr6:154832845 CNKSR3 0.26 5.66 0.3 3.37e-8 Diabetic kidney disease; CRC cis rs4819052 0.807 rs1075788 chr21:46666564 T/G cg11663144 chr21:46675770 NA -0.78 -12.98 -0.58 2.25e-31 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC trans rs7873102 0.702 rs7028020 chr9:38007747 C/T cg01543582 chr4:190862539 FRG1 -0.31 -5.99 -0.31 5.57e-9 Brain structure; CRC trans rs7546 0.505 rs760118 chr16:4940994 A/G cg19252218 chr17:41477271 ARL4D -0.43 -6.33 -0.33 8.08e-10 Cancer; CRC cis rs4285028 0.747 rs9820511 chr3:121361345 G/A cg20356878 chr3:121714668 ILDR1 -0.42 -5.9 -0.31 8.81e-9 Multiple sclerosis; CRC cis rs10504229 0.679 rs75402323 chr8:58136227 A/G cg24829409 chr8:58192753 C8orf71 -0.55 -8.03 -0.4 1.71e-14 Developmental language disorder (linguistic errors); CRC cis rs748404 0.631 rs7163288 chr15:43671355 A/G cg15269541 chr15:43626905 ADAL -0.37 -5.72 -0.3 2.43e-8 Lung cancer; CRC cis rs68170813 0.559 rs77829121 chr7:106968470 A/G cg02696742 chr7:106810147 HBP1 -0.6 -6.71 -0.35 8.65e-11 Coronary artery disease; CRC cis rs1559088 0.576 rs10407255 chr19:33581150 A/G cg17764715 chr19:33622953 WDR88 -0.47 -7.06 -0.36 1.01e-11 Bone ultrasound measurement (broadband ultrasound attenuation); CRC cis rs12134245 0.874 rs34842487 chr1:92021611 C/T cg07090678 chr1:91966139 CDC7 0.37 5.85 0.31 1.19e-8 Breast cancer; CRC cis rs17021463 0.726 rs62320444 chr4:95261251 C/T cg11021082 chr4:95130006 SMARCAD1 0.48 7.33 0.37 1.82e-12 Testicular germ cell tumor; CRC cis rs11123170 0.569 rs1049137 chr2:113975110 A/G cg11763394 chr2:113992921 PAX8;LOC440839;LOC654433 0.5 5.91 0.31 8.58e-9 Renal function-related traits (BUN); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg19355881 chr6:34759549 UHRF1BP1 0.38 6.08 0.32 3.26e-9 Liver disease severity in Alagille syndrome; CRC cis rs12431939 1.000 rs67065973 chr14:51656225 T/C cg23942311 chr14:51606299 NA -0.53 -6.4 -0.33 5.41e-10 Cancer; CRC cis rs2354432 0.607 rs72692962 chr1:146802674 C/A cg25205988 chr1:146714368 CHD1L -1.14 -9.47 -0.46 5.64e-19 Mitochondrial DNA levels; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg25652642 chr19:10514370 MIR1181;CDC37 0.48 6.57 0.34 1.94e-10 Anxiety disorder; CRC cis rs9910055 0.762 rs184478 chr17:42209751 C/G cg16434002 chr17:42200994 HDAC5 0.43 5.9 0.31 9.08e-9 Total body bone mineral density; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg13365641 chr2:211036230 C2orf67 0.38 6.29 0.33 9.95e-10 Liver disease severity in Alagille syndrome; CRC cis rs55726902 0.761 rs2544030 chr12:48195451 G/A cg14736327 chr12:48174669 SLC48A1 -0.48 -6.33 -0.33 7.9e-10 Allergic disease (asthma, hay fever or eczema); CRC cis rs73200209 0.744 rs17498802 chr12:116642212 T/G cg01776926 chr12:116560359 MED13L -0.61 -7.08 -0.36 8.97e-12 Total body bone mineral density; CRC trans rs11039798 0.588 rs6485869 chr11:48576903 G/T cg15704280 chr7:45808275 SEPT13 0.65 7.06 0.36 1.01e-11 Axial length; CRC cis rs1044826 0.642 rs176983 chr3:139213755 G/A cg00490450 chr3:139108681 COPB2 0.44 6.53 0.34 2.57e-10 Obesity-related traits; CRC cis rs780096 0.506 rs2950834 chr2:27627366 G/A cg27432699 chr2:27873401 GPN1 -0.5 -7.58 -0.39 3.5e-13 Total body bone mineral density; CRC cis rs501120 0.564 rs2804036 chr10:44680405 A/G cg09554077 chr10:44749378 NA 0.49 6.79 0.35 5.23e-11 Coronary artery disease;Coronary heart disease; CRC cis rs2976388 0.556 rs4736323 chr8:143830359 C/T cg22687807 chr8:143858763 LYNX1 -0.42 -6.34 -0.33 7.43e-10 Urinary tract infection frequency; CRC cis rs9858542 1.000 rs34762726 chr3:49689210 G/A cg03060546 chr3:49711283 APEH -0.5 -6.81 -0.35 4.68e-11 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs11098699 0.821 rs6830258 chr4:124230345 A/G cg09941581 chr4:124220074 SPATA5 -0.4 -5.94 -0.31 7.44e-9 Mosquito bite size; CRC cis rs6502050 0.799 rs7502524 chr17:80107261 C/T cg22110888 chr17:80059540 CCDC57 0.4 6.44 0.33 4.17e-10 Life satisfaction; CRC cis rs4588572 0.644 rs891150 chr5:77761794 G/A cg11446398 chr5:77624930 NA 0.43 6.24 0.33 1.37e-9 Triglycerides; CRC cis rs561341 1.000 rs2470267 chr17:30274132 G/A cg19193384 chr17:30244184 NA -0.51 -6.45 -0.33 4.05e-10 Hip circumference adjusted for BMI; CRC trans rs6703335 0.870 rs10803142 chr1:243598234 A/G cg16304302 chr12:27486485 ARNTL2 0.45 6.52 0.34 2.65e-10 Schizophrenia;Schizophrenia, schizoaffective disorder or bipolar disorder; CRC cis rs13191362 1.000 rs35383933 chr6:163002869 G/A cg06582575 chr6:163149167 PACRG;PARK2 0.77 10.7 0.51 3.98e-23 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs769267 0.895 rs2965189 chr19:19519518 G/T cg02546618 chr19:19431379 KIAA0892;SF4 0.45 6.37 0.33 6.21e-10 Tonsillectomy; CRC cis rs853679 0.699 rs9468318 chr6:28209531 T/A cg06470822 chr6:28175283 NA 0.76 8.05 0.41 1.49e-14 Depression; CRC cis rs7538876 0.903 rs7528427 chr1:17746273 C/T cg01904812 chr1:17746340 RCC2 0.36 5.93 0.31 7.49e-9 Basal cell carcinoma; CRC cis rs919433 0.927 rs6759834 chr2:198204860 C/T cg03934865 chr2:198174659 NA -0.39 -5.81 -0.31 1.47e-8 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC cis rs10504229 0.683 rs6984765 chr8:58127124 T/C cg22535103 chr8:58192502 C8orf71 -0.7 -9.34 -0.46 1.47e-18 Developmental language disorder (linguistic errors); CRC cis rs35146811 0.735 rs6465766 chr7:99785671 A/G cg13334819 chr7:99746414 C7orf59 -0.51 -6.74 -0.35 6.99e-11 Coronary artery disease; CRC cis rs9487051 0.652 rs6568559 chr6:109592751 C/T cg12927641 chr6:109611667 NA -0.38 -6.74 -0.35 7.22e-11 Reticulocyte fraction of red cells; CRC cis rs1568889 1.000 rs12797712 chr11:28290890 G/A cg06544937 chr11:28130018 METT5D1;KIF18A 0.78 10.73 0.51 3.22e-23 Bipolar disorder; CRC cis rs6963495 0.818 rs73192120 chr7:105171156 C/T cg13798780 chr7:105162888 PUS7 0.68 8.04 0.41 1.59e-14 Bipolar disorder (body mass index interaction); CRC cis rs4713118 0.588 rs200994 chr6:27813813 A/C cg15786705 chr6:28176104 NA -0.57 -7.3 -0.37 2.16e-12 Parkinson's disease; CRC trans rs10253216 0.684 rs10245233 chr7:16860089 G/C cg00402074 chr6:46889742 GPR116 0.33 6.14 0.32 2.43e-9 Adverse response to chemotherapy (neutropenia/leucopenia) (cisplatin); CRC cis rs2929278 0.617 rs11070410 chr15:44057045 A/G cg02155558 chr15:43621948 ADAL;LCMT2 -0.43 -5.92 -0.31 8.07e-9 Schizophrenia; CRC cis rs4588572 0.644 rs10805920 chr5:77698222 G/A cg11446398 chr5:77624930 NA 0.43 6.33 0.33 8.01e-10 Triglycerides; CRC cis rs2976388 0.565 rs2572905 chr8:143797104 C/T cg22687807 chr8:143858763 LYNX1 0.49 8.79 0.44 8.36e-17 Urinary tract infection frequency; CRC cis rs478304 0.903 rs61895677 chr11:65549415 T/C cg08755490 chr11:65554678 OVOL1 0.4 5.79 0.3 1.66e-8 Acne (severe); CRC cis rs35306767 0.714 rs11250228 chr10:1074887 A/G cg20503657 chr10:835505 NA 0.66 8.79 0.44 8.27e-17 Eosinophil percentage of granulocytes; CRC cis rs17345786 0.954 rs17508319 chr3:101318903 G/A cg11279151 chr3:101281821 RG9MTD1 -0.7 -8.88 -0.44 4.55e-17 Colonoscopy-negative controls vs population controls; CRC trans rs2070433 0.534 rs2839269 chr21:47891491 A/G cg19571106 chr8:9762850 NA -0.32 -6.28 -0.33 1.09e-9 Lymphocyte counts; CRC cis rs6604026 0.740 rs7536563 chr1:93349046 A/G cg17283838 chr1:93427260 FAM69A -0.47 -6.33 -0.33 7.8e-10 Multiple sclerosis; CRC cis rs853679 0.517 rs35227624 chr6:28132726 A/G cg12172441 chr6:28176163 NA 0.64 7.53 0.38 5.03e-13 Depression; CRC trans rs8002861 0.905 rs12874535 chr13:44433565 A/G cg12856521 chr11:46389249 DGKZ -0.42 -6.77 -0.35 5.85e-11 Leprosy; CRC cis rs3796352 1.000 rs11718538 chr3:52975987 C/G cg07884673 chr3:53033167 SFMBT1 0.69 6.12 0.32 2.67e-9 Immune reponse to smallpox (secreted IL-2); CRC cis rs7777484 0.500 rs2533885 chr7:2835655 C/T cg09658497 chr7:2847517 GNA12 -0.38 -6.31 -0.33 9.14e-10 Height; CRC cis rs7487075 0.786 rs7980775 chr12:46674873 A/G cg22049899 chr12:47219821 SLC38A4 0.33 6.02 0.32 4.59e-9 Itch intensity from mosquito bite; CRC cis rs12286929 0.839 rs12790574 chr11:115009145 C/T cg04055981 chr11:115044050 NA 0.36 5.67 0.3 3.14e-8 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs1448094 0.511 rs4897823 chr12:86161484 C/T cg19622623 chr12:86230825 RASSF9 -0.37 -5.8 -0.3 1.57e-8 Major depressive disorder; CRC cis rs1129187 0.755 rs9471986 chr6:42944127 A/G cg09436375 chr6:42928200 GNMT -0.34 -6.3 -0.33 9.3e-10 Alzheimer's disease in APOE e4+ carriers; CRC cis rs2354432 1.000 rs2120003 chr1:146690635 A/G cg25205988 chr1:146714368 CHD1L 0.94 8.71 0.43 1.54e-16 Mitochondrial DNA levels; CRC cis rs10791097 0.694 rs10791100 chr11:130738946 T/A cg12179176 chr11:130786555 SNX19 0.75 12.76 0.58 1.4e-30 Autism spectrum disorder or schizophrenia;Schizophrenia; CRC cis rs8072100 0.582 rs3826536 chr17:45501967 T/A cg08085267 chr17:45401833 C17orf57 -0.58 -8.69 -0.43 1.71e-16 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs8077889 1.000 rs59044152 chr17:41888747 A/G cg26893861 chr17:41843967 DUSP3 0.95 12.2 0.56 1.64e-28 Triglycerides; CRC cis rs7937682 0.889 rs558736 chr11:111500760 C/G cg19812747 chr11:111475976 SIK2 -0.59 -10.08 -0.49 5.11e-21 Primary sclerosing cholangitis; CRC cis rs9488822 0.676 rs12190737 chr6:116328128 C/A cg15226275 chr6:116381976 FRK 0.3 8.5 0.42 6.55e-16 Cholesterol, total;LDL cholesterol; CRC trans rs61931739 0.817 rs11833948 chr12:34276942 G/T cg26384229 chr12:38710491 ALG10B 0.46 6.47 0.34 3.64e-10 Morning vs. evening chronotype; CRC cis rs8060686 0.565 rs8057577 chr16:68033143 C/T cg08314208 chr16:67682810 RLTPR -0.65 -6.67 -0.34 1.11e-10 HDL cholesterol;Metabolic syndrome; CRC trans rs4942242 0.663 rs1390371 chr13:44211727 A/G cg26741380 chr15:41871084 TYRO3 0.45 6.2 0.32 1.73e-9 Response to tocilizumab in rheumatoid arthritis; CRC cis rs35146811 0.735 rs1727139 chr7:99815367 C/T cg00553149 chr7:99775558 STAG3;GPC2 -0.24 -5.69 -0.3 2.82e-8 Coronary artery disease; CRC cis rs10256972 0.552 rs2960837 chr7:1203957 A/G cg04025307 chr7:1156635 C7orf50 0.67 10.68 0.51 4.82e-23 Longevity;Endometriosis; CRC cis rs11690256 1.000 rs11690256 chr2:129542767 A/G cg16353174 chr2:129543148 NA 0.43 6.07 0.32 3.46e-9 Symmetrical dimethylarginine levels; CRC cis rs10193935 0.901 rs10169971 chr2:42602189 G/A cg27598129 chr2:42591480 NA -0.7 -7.5 -0.38 6e-13 Colonoscopy-negative controls vs population controls; CRC cis rs4588572 0.643 rs6874309 chr5:77774498 A/T cg11547950 chr5:77652471 NA 0.51 6.97 0.36 1.75e-11 Triglycerides; CRC cis rs2408955 0.501 rs8716 chr12:48539482 T/G cg24011408 chr12:48396354 COL2A1 0.45 6.63 0.34 1.34e-10 Glycated hemoglobin levels; CRC cis rs4523957 0.928 rs216176 chr17:2168509 G/C cg16513277 chr17:2031491 SMG6 0.57 9.66 0.47 1.33e-19 Autism spectrum disorder or schizophrenia;Schizophrenia; CRC cis rs7618915 0.571 rs7623199 chr3:52605974 C/T cg18099408 chr3:52552593 STAB1 -0.45 -7.39 -0.38 1.22e-12 Bipolar disorder; CRC cis rs3126085 0.935 rs3126043 chr1:152256030 C/G cg09127314 chr1:152161683 NA 0.48 6.22 0.32 1.49e-9 Atopic dermatitis; CRC cis rs4243830 0.510 rs7518459 chr1:6596678 C/G cg22792644 chr1:6614718 TAS1R1;NOL9 -0.79 -9.53 -0.47 3.6e-19 Body mass index; CRC cis rs3849570 1.000 rs3860595 chr3:81811784 A/G cg07356753 chr3:81810745 GBE1 -0.58 -8.2 -0.41 5.6e-15 Waist circumference;Body mass index; CRC cis rs6964587 1.000 rs11982047 chr7:91705274 G/A cg17063962 chr7:91808500 NA 0.76 12.15 0.56 2.61e-28 Breast cancer; CRC cis rs453301 0.658 rs9650616 chr8:8869199 T/G cg14979609 chr8:8086686 FLJ10661 0.36 5.82 0.31 1.44e-8 Joint mobility (Beighton score); CRC cis rs4332037 0.805 rs10278591 chr7:1921362 A/G cg23422044 chr7:1970798 MAD1L1 0.59 8.23 0.41 4.41e-15 Bipolar disorder; CRC cis rs17384381 0.953 rs12122816 chr1:85792384 C/T cg16011679 chr1:85725395 C1orf52 0.64 6.49 0.34 3.15e-10 Lobe attachment (rater-scored or self-reported); CRC cis rs911186 0.786 rs72842197 chr6:27067083 C/T cg12292205 chr6:26970375 C6orf41 -0.79 -8.63 -0.43 2.67e-16 Autism spectrum disorder or schizophrenia; CRC cis rs72634258 0.740 rs4489581 chr1:8174495 A/C cg26816564 chr1:7831052 VAMP3 -0.48 -5.79 -0.3 1.67e-8 Inflammatory bowel disease; CRC trans rs1005277 0.522 rs289648 chr10:37971837 T/C cg27523141 chr10:43048294 ZNF37B 0.43 6.04 0.32 4.19e-9 Extrinsic epigenetic age acceleration; CRC cis rs873946 0.586 rs12774727 chr10:134569910 T/C cg26818010 chr10:134567672 INPP5A -0.71 -9.21 -0.45 4.06e-18 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CRC cis rs11785400 0.793 rs34875149 chr8:143736131 G/A cg10596483 chr8:143751796 JRK 0.44 5.88 0.31 1.01e-8 Schizophrenia; CRC cis rs875971 0.895 rs10447522 chr7:65796074 A/G cg11764359 chr7:65958608 NA -0.58 -8.58 -0.43 3.7e-16 Aortic root size; CRC cis rs6952808 0.542 rs10243920 chr7:1950385 G/A cg22963979 chr7:1858916 MAD1L1 -0.42 -6.69 -0.35 9.33e-11 Bipolar disorder and schizophrenia; CRC cis rs7917772 0.503 rs7068535 chr10:104349127 C/T cg04362960 chr10:104952993 NT5C2 -0.42 -5.92 -0.31 7.95e-9 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC cis rs58688157 0.883 rs34793529 chr11:575800 T/G cg16486109 chr11:613632 IRF7 0.63 11.05 0.52 2.33e-24 Systemic lupus erythematosus; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg10075436 chr19:59084928 MZF1;LOC100131691 0.5 6.43 0.33 4.54e-10 Thyroid stimulating hormone; CRC cis rs926938 0.584 rs360606 chr1:115391769 C/T cg12756093 chr1:115239321 AMPD1 0.59 8.83 0.44 6.54e-17 Autism; CRC cis rs10992471 0.603 rs7865019 chr9:95325631 A/G cg14631576 chr9:95140430 CENPP -0.38 -6.63 -0.34 1.38e-10 Visceral adipose tissue/subcutaneous adipose tissue ratio; CRC cis rs6502050 0.835 rs8070014 chr17:80115247 T/G cg25804541 chr17:80189381 SLC16A3 -0.3 -5.88 -0.31 9.83e-9 Life satisfaction; CRC cis rs7772486 0.790 rs9376970 chr6:146241472 A/C cg23711669 chr6:146136114 FBXO30 -0.73 -12.86 -0.58 6.14e-31 Lobe attachment (rater-scored or self-reported); CRC cis rs9611565 0.512 rs4820444 chr22:42202606 A/G cg06481639 chr22:41940642 POLR3H 0.56 6.48 0.34 3.3e-10 Vitiligo; CRC cis rs9491140 0.539 rs10872285 chr6:124689145 C/T cg22366943 chr6:124882293 NKAIN2 0.59 8.33 0.42 2.17e-15 Neuroticism; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg05739825 chr11:125439882 EI24 0.48 6.77 0.35 6e-11 Response to antipsychotic treatment; CRC cis rs1843834 0.898 rs4674936 chr2:225553731 C/T cg22455342 chr2:225449267 CUL3 0.48 6.38 0.33 6.04e-10 IgE levels in asthmatics (D.p. specific); CRC cis rs7224685 0.501 rs2727064 chr17:3934101 A/G cg10724054 chr17:3904396 NA -0.46 -7.5 -0.38 5.99e-13 Type 2 diabetes; CRC cis rs344364 0.511 rs56077812 chr16:1948870 T/G cg03013636 chr16:1946785 NA 0.58 7.08 0.36 8.69e-12 Glomerular filtration rate in chronic kidney disease; CRC cis rs972578 1.000 rs5759078 chr22:43393042 G/C cg01576275 chr22:43409880 NA -0.49 -7.91 -0.4 3.97e-14 Mean platelet volume; CRC cis rs7587476 0.822 rs6726763 chr2:215681580 T/G cg04004882 chr2:215674386 BARD1 0.67 9.45 0.46 6.69e-19 Neuroblastoma; CRC cis rs4713118 0.621 rs9368548 chr6:28034737 A/G cg12172441 chr6:28176163 NA 0.59 7.18 0.37 4.72e-12 Parkinson's disease; CRC cis rs7615952 0.599 rs6779141 chr3:125709995 A/T cg18479299 chr3:125709523 NA -0.53 -6.36 -0.33 6.78e-10 Blood pressure (smoking interaction); CRC cis rs9916302 0.861 rs12150493 chr17:37586154 T/C cg15445000 chr17:37608096 MED1 0.43 9.48 0.46 5.3e-19 Glomerular filtration rate (creatinine); CRC trans rs12478296 1.000 rs4973685 chr2:243019089 A/C cg18288967 chr1:45987694 PRDX1 0.61 6.7 0.35 8.83e-11 Obesity-related traits; CRC trans rs561341 0.941 rs8066156 chr17:30361629 A/G cg20587970 chr11:113659929 NA -1.06 -15.36 -0.65 1.63e-40 Hip circumference adjusted for BMI; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg00960509 chr1:21671908 ECE1 0.38 6.15 0.32 2.26e-9 Liver disease severity in Alagille syndrome; CRC cis rs10504229 1.000 rs17216620 chr8:58169412 A/G cg02290350 chr8:58132656 NA -0.43 -6.12 -0.32 2.64e-9 Developmental language disorder (linguistic errors); CRC trans rs11098499 0.754 rs878376 chr4:120237702 G/A cg25214090 chr10:38739885 LOC399744 0.53 8.52 0.43 5.72e-16 Corneal astigmatism; CRC cis rs9393692 0.846 rs9366651 chr6:26336696 G/T cg13736514 chr6:26305472 NA -0.61 -11.33 -0.53 2.31e-25 Educational attainment; CRC cis rs9868809 0.505 rs11706983 chr3:48738678 A/G cg00383909 chr3:49044727 WDR6 0.79 8.04 0.41 1.68e-14 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; CRC cis rs2404602 0.716 rs284895 chr15:76751225 C/G cg03037974 chr15:76606532 NA -0.7 -12.23 -0.56 1.33e-28 Blood metabolite levels; CRC cis rs1322512 1.000 rs1727054 chr6:152947742 A/G cg03415253 chr6:152958462 SYNE1 -0.41 -6.37 -0.33 6.5e-10 Tonometry; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg06175075 chr4:146055261 OTUD4 -0.38 -6.31 -0.33 8.94e-10 Liver disease severity in Alagille syndrome; CRC trans rs7615952 0.546 rs2979340 chr3:125341384 C/T cg02007433 chr3:129722099 NA -0.51 -6.26 -0.33 1.19e-9 Blood pressure (smoking interaction); CRC cis rs2012796 0.743 rs8020575 chr14:81859521 G/A cg02996355 chr14:81879375 NA 0.62 9.45 0.46 6.77e-19 Night sleep phenotypes; CRC cis rs17376456 0.877 rs10064520 chr5:93427358 T/C cg09848695 chr5:92956644 FAM172A;MIR2277 0.65 6.03 0.32 4.38e-9 Diabetic retinopathy; CRC cis rs9322193 0.884 rs11155689 chr6:150129606 T/C cg05861140 chr6:150128134 PCMT1 -0.43 -7.01 -0.36 1.39e-11 Lung cancer; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg12443622 chr17:42219154 C17orf53 0.51 7.2 0.37 4.16e-12 Response to antipsychotic treatment; CRC cis rs9393777 0.513 rs67540232 chr6:27140866 T/A cg12292205 chr6:26970375 C6orf41 -0.76 -8.08 -0.41 1.29e-14 Intelligence (multi-trait analysis); CRC cis rs7113874 0.610 rs1446462 chr11:8566343 C/T cg17679104 chr11:8615758 STK33 -0.36 -6.01 -0.31 4.87e-9 Body mass index in physically active individuals;Body mass index (joint analysis main effects and physical activity interaction); CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg23600533 chr11:64885249 ZNHIT2 -0.4 -5.98 -0.31 5.84e-9 Myopia (pathological); CRC cis rs6502050 0.871 rs8072702 chr17:80074280 C/T cg13198984 chr17:80129470 CCDC57 -0.46 -7.99 -0.4 2.36e-14 Life satisfaction; CRC trans rs2727020 0.675 rs7929401 chr11:49350832 C/A cg11707556 chr5:10655725 ANKRD33B -0.43 -6.58 -0.34 1.85e-10 Coronary artery disease; CRC trans rs1973993 0.967 rs11165643 chr1:96924097 C/T cg10631902 chr5:14652156 NA 0.49 8.76 0.43 1.04e-16 Weight; CRC cis rs801193 0.844 rs7779971 chr7:66161790 T/C cg00343986 chr7:65444356 GUSB 0.49 7.22 0.37 3.53e-12 Aortic root size; CRC cis rs561341 0.882 rs563539 chr17:30307958 A/G cg00745463 chr17:30367425 LRRC37B -0.7 -8.47 -0.42 8.1e-16 Hip circumference adjusted for BMI; CRC cis rs9611519 0.780 rs2235850 chr22:41657626 C/T cg03806693 chr22:41940476 POLR3H -0.66 -9.11 -0.45 8.2e-18 Neuroticism; CRC cis rs9549260 0.755 rs7990923 chr13:41215972 A/G cg21288729 chr13:41239152 FOXO1 0.48 7.56 0.38 4.03e-13 Red blood cell count; CRC cis rs4862750 0.881 rs6813866 chr4:187872161 T/G cg07414643 chr4:187882934 NA 0.37 6.32 0.33 8.36e-10 Lobe attachment (rater-scored or self-reported); CRC cis rs713587 0.713 rs1982200 chr2:25205427 C/T cg22495460 chr2:25135724 ADCY3 0.67 11.12 0.52 1.38e-24 Body mass index in non-asthmatics; CRC cis rs10504229 0.683 rs66893068 chr8:58144238 A/G cg21724239 chr8:58056113 NA 0.47 6.56 0.34 2.06e-10 Developmental language disorder (linguistic errors); CRC cis rs1957429 0.808 rs11158564 chr14:65335082 G/A cg23373153 chr14:65346875 NA 0.67 6.82 0.35 4.47e-11 Pediatric areal bone mineral density (radius); CRC cis rs2032447 0.798 rs807212 chr6:26065621 A/G cg03264133 chr6:25882463 NA -0.5 -6.72 -0.35 8.02e-11 Intelligence (multi-trait analysis); CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg11912956 chr7:73588697 EIF4H 0.44 5.97 0.31 6.12e-9 Thyroid stimulating hormone; CRC cis rs910316 0.737 rs175048 chr14:75479894 A/T cg08847533 chr14:75593920 NEK9 -0.83 -14.42 -0.62 7.17e-37 Height; CRC cis rs10782582 0.609 rs946163 chr1:76383049 A/G cg05598546 chr1:76251766 SNORD45C;RABGGTB -0.43 -5.65 -0.3 3.43e-8 Daytime sleep phenotypes; CRC cis rs7586879 0.639 rs7580081 chr2:25097072 G/C cg04586622 chr2:25135609 ADCY3 -0.56 -10.33 -0.49 7.53e-22 Body mass index; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg10473508 chr5:172068142 NEURL1B 0.49 7.02 0.36 1.25e-11 Response to antipsychotic treatment; CRC cis rs12188164 0.561 rs2251843 chr5:457955 C/T cg26850624 chr5:429559 AHRR -0.51 -8.54 -0.43 4.91e-16 Cystic fibrosis severity; CRC trans rs28411352 0.922 rs12116786 chr1:38247095 A/G cg19525872 chr12:130934808 RIMBP2 -0.41 -6.06 -0.32 3.72e-9 Rheumatoid arthritis; CRC cis rs2976388 0.507 rs13259549 chr8:143838519 T/C cg20041105 chr8:143859282 LYNX1 0.57 10.09 0.49 4.91e-21 Urinary tract infection frequency; CRC cis rs3733585 0.673 rs10018204 chr4:9964570 C/T cg00071950 chr4:10020882 SLC2A9 -0.54 -9.65 -0.47 1.42e-19 Cleft plate (environmental tobacco smoke interaction); CRC cis rs13118159 0.934 rs2878608 chr4:1354286 C/G cg15763984 chr4:1342303 KIAA1530 0.34 5.82 0.31 1.4e-8 Longevity; CRC cis rs2549003 1.000 rs3846732 chr5:131816087 T/C cg21138405 chr5:131827807 IRF1 0.57 11.37 0.53 1.67e-25 Asthma (sex interaction); CRC cis rs6500395 1.000 rs1420704 chr16:48716902 C/T cg04672837 chr16:48644449 N4BP1 -0.45 -6.63 -0.34 1.38e-10 Response to tocilizumab in rheumatoid arthritis; CRC cis rs62408225 1.000 rs2325291 chr6:90986686 G/A cg06866423 chr6:90926672 BACH2 0.5 8.22 0.41 4.88e-15 Eosinophil counts;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC cis rs514406 0.798 rs576650 chr1:53327207 C/T cg08859206 chr1:53392774 SCP2 -0.59 -9.58 -0.47 2.38e-19 Monocyte count; CRC cis rs6693567 0.507 rs828784 chr1:150335240 T/A cg04165759 chr1:150448943 RPRD2 0.34 5.66 0.3 3.21e-8 Migraine; CRC cis rs2836950 0.501 rs11702505 chr21:40700614 G/T cg11890956 chr21:40555474 PSMG1 -0.6 -8.77 -0.44 9.96e-17 Menarche (age at onset); CRC cis rs75920871 0.588 rs1871756 chr11:116953645 G/A cg01368799 chr11:117014884 PAFAH1B2 -0.43 -5.96 -0.31 6.61e-9 Subjective well-being; CRC cis rs7927771 0.542 rs7108479 chr11:47781460 G/T cg20307385 chr11:47447363 PSMC3 0.45 6.57 0.34 1.92e-10 Subjective well-being; CRC cis rs2227564 0.649 rs2688626 chr10:75611090 G/A cg00564723 chr10:75632066 CAMK2G -0.37 -8.77 -0.44 9.6e-17 Crohn's disease;Inflammatory bowel disease; CRC cis rs7793919 0.764 rs6944865 chr7:4766383 A/T cg09789173 chr7:4769017 FOXK1 0.72 12.45 0.57 2e-29 Mosquito bite size; CRC cis rs7804356 1.000 rs73069507 chr7:26877536 A/G cg03456212 chr7:26904342 SKAP2 -0.49 -5.62 -0.3 4.1e-8 Type 1 diabetes; CRC trans rs2727020 0.615 rs10128582 chr11:49447424 C/T cg15704280 chr7:45808275 SEPT13 -0.91 -17.22 -0.69 7.75e-48 Coronary artery disease; CRC cis rs12230513 0.732 rs12582120 chr12:55830064 A/G cg19537932 chr12:55886519 OR6C68 -0.73 -9.44 -0.46 7.02e-19 Contrast sensitivity; CRC cis rs801193 0.660 rs4610622 chr7:66224497 T/C cg18912574 chr7:65842487 NCRNA00174 0.36 6.0 0.31 5.32e-9 Aortic root size; CRC cis rs807029 0.533 rs67813203 chr10:102738551 A/G cg04662943 chr10:102668895 NA 0.63 7.57 0.39 3.74e-13 Ejection fraction in Tripanosoma cruzi seropositivity; CRC cis rs1005277 0.579 rs2749612 chr10:38488610 G/A cg25517755 chr10:38738941 LOC399744 -0.44 -6.35 -0.33 7.08e-10 Extrinsic epigenetic age acceleration; CRC cis rs9427116 0.967 rs7547072 chr1:154639255 A/G cg24304309 chr1:154577895 ADAR -0.37 -6.14 -0.32 2.42e-9 Blood protein levels; CRC cis rs2857891 1.000 rs2595500 chr11:6963165 C/T cg22096450 chr11:6947773 ZNF215 -0.57 -6.35 -0.33 6.98e-10 Response to cytadine analogues (cytosine arabinoside); CRC cis rs9814567 1.000 rs62271515 chr3:134300507 T/A cg06109529 chr3:134205091 CEP63;ANAPC13 -0.8 -11.7 -0.54 1.13e-26 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs8060686 0.641 rs36086450 chr16:68046996 A/C cg26727032 chr16:67993705 SLC12A4 -0.56 -6.22 -0.32 1.54e-9 HDL cholesterol;Metabolic syndrome; CRC cis rs7412746 0.587 rs11204722 chr1:150730184 A/C cg17724175 chr1:150552817 MCL1 -0.48 -7.12 -0.37 6.96e-12 Melanoma; CRC cis rs2204008 0.604 rs11172718 chr12:38069819 T/C cg13010199 chr12:38710504 ALG10B 0.46 6.1 0.32 3.03e-9 Bladder cancer; CRC cis rs514406 0.505 rs387436 chr1:53179376 C/T cg24675658 chr1:53192096 ZYG11B 0.68 10.25 0.49 1.37e-21 Monocyte count; CRC trans rs9291683 0.510 rs4318649 chr4:10016815 T/C cg26043149 chr18:55253948 FECH 0.5 7.46 0.38 7.59e-13 Bone mineral density; CRC cis rs12620999 0.887 rs6723783 chr2:237963572 C/A cg23555395 chr2:238036564 NA 0.45 6.72 0.35 7.96e-11 Systemic lupus erythematosus; CRC trans rs55675132 0.548 rs3911879 chr1:115378032 C/T cg25493687 chr8:27288214 PTK2B 0.51 6.43 0.33 4.62e-10 Schizophrenia; CRC cis rs2120019 1.000 rs12898259 chr15:75369780 G/A cg11632617 chr15:75315747 PPCDC -0.56 -7.96 -0.4 2.86e-14 Blood trace element (Zn levels); CRC cis rs12893668 0.572 rs12590968 chr14:104136633 G/C cg01849466 chr14:104193079 ZFYVE21 -0.41 -6.05 -0.32 3.98e-9 Reticulocyte count; CRC cis rs2982552 0.873 rs1999807 chr6:152064199 C/G cg22157087 chr6:152012887 ESR1 0.38 5.83 0.31 1.3e-8 Bone properties (heel); CRC cis rs10504229 0.596 rs6991216 chr8:58115586 T/C cg24829409 chr8:58192753 C8orf71 -0.55 -8.03 -0.4 1.71e-14 Developmental language disorder (linguistic errors); CRC cis rs9322193 1.000 rs9399693 chr6:149933854 C/T cg13206674 chr6:150067644 NUP43 0.62 9.23 0.45 3.46e-18 Lung cancer; CRC cis rs4901869 0.966 rs60800733 chr14:59337778 A/G cg02291164 chr14:59296302 NA 0.35 6.36 0.33 6.58e-10 Panic disorder; CRC cis rs11971779 0.648 rs9656512 chr7:139054046 A/G cg23387468 chr7:139079360 LUC7L2 0.41 7.04 0.36 1.14e-11 Diisocyanate-induced asthma; CRC cis rs6089584 0.888 rs2892060 chr20:60617955 G/T cg18761221 chr20:60518478 NA 0.45 7.21 0.37 3.8e-12 Body mass index; CRC cis rs1046896 0.586 rs9897951 chr17:80810662 T/C cg16060761 chr17:80687452 NA -0.46 -6.05 -0.32 3.84e-9 Glycated hemoglobin levels; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg27018013 chr16:2524149 TBC1D24 0.46 6.21 0.32 1.6e-9 Anxiety disorder; CRC cis rs7107174 1.000 rs10899481 chr11:78058721 A/T cg02023728 chr11:77925099 USP35 -0.47 -8.33 -0.42 2.18e-15 Testicular germ cell tumor; CRC trans rs2727020 0.558 rs1164675 chr11:49325972 C/T cg21153622 chr11:89784906 NA 0.41 6.27 0.33 1.15e-9 Coronary artery disease; CRC cis rs6952808 0.594 rs3778964 chr7:2138109 C/T cg21782813 chr7:2030301 MAD1L1 0.54 9.45 0.46 6.57e-19 Bipolar disorder and schizophrenia; CRC cis rs4665809 1.000 rs1560868 chr2:26281459 A/T cg27170947 chr2:26402098 FAM59B 0.45 5.94 0.31 7.09e-9 Gut microbiome composition (summer); CRC cis rs668210 0.793 rs507672 chr11:65767153 C/T cg02202077 chr11:65769826 EIF1AD;BANF1 -0.49 -6.43 -0.33 4.43e-10 Cerebrospinal fluid biomarker levels; CRC cis rs3751196 0.803 rs74625467 chr12:104185164 C/A cg02344784 chr12:104178138 NT5DC3 0.7 7.14 0.37 6.12e-12 Sense of smell; CRC cis rs6089584 0.853 rs1740367 chr20:60574834 C/T cg23262073 chr20:60523788 NA -0.5 -7.72 -0.39 1.39e-13 Body mass index; CRC cis rs7208859 0.673 rs73277967 chr17:29184166 T/A cg14008862 chr17:28927542 LRRC37B2 0.55 5.74 0.3 2.1e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs4665809 0.590 rs13006973 chr2:26454707 C/T cg25036284 chr2:26402008 FAM59B 0.61 7.76 0.39 1.09e-13 Gut microbiome composition (summer); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg04740679 chr13:114016140 GRTP1 0.34 7.04 0.36 1.16e-11 Liver disease severity in Alagille syndrome; CRC cis rs10752881 0.905 rs10797830 chr1:183036274 A/T ch.1.3577855R chr1:183094577 LAMC1 0.82 14.22 0.62 4.34e-36 Colorectal cancer; CRC cis rs2204008 0.754 rs11181244 chr12:38302454 T/C cg26384229 chr12:38710491 ALG10B 0.69 9.77 0.47 5.73e-20 Bladder cancer; CRC cis rs10888329 0.707 rs4916106 chr1:248353537 G/A cg00666640 chr1:248458726 OR2T12 0.43 7.46 0.38 7.92e-13 Autism spectrum disorder; CRC cis rs1799949 0.602 rs8176257 chr17:41216205 G/T cg25072359 chr17:41440525 NA 0.44 5.93 0.31 7.79e-9 Menopause (age at onset); CRC cis rs10924970 0.687 rs4553178 chr1:235364543 T/C cg09010748 chr1:235293032 TOMM20 -0.4 -5.64 -0.3 3.72e-8 Asthma; CRC cis rs6840360 1.000 rs6823002 chr4:152604467 T/G cg09659197 chr4:152720779 NA 0.5 10.59 0.5 9.76e-23 Intelligence (multi-trait analysis); CRC cis rs7618915 0.547 rs11130313 chr3:52676190 A/C cg07507251 chr3:52567010 NT5DC2 0.42 6.04 0.32 4.11e-9 Bipolar disorder; CRC cis rs6912958 0.500 rs2025486 chr6:87796886 T/C cg12350822 chr6:88032061 C6orf162;GJB7 -0.39 -7.38 -0.38 1.27e-12 Monocyte percentage of white cells; CRC cis rs7917772 0.560 rs7912339 chr10:104373758 G/C cg11453585 chr10:104263688 ACTR1A;SUFU 0.82 15.13 0.64 1.23e-39 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC cis rs7267979 0.816 rs374701 chr20:25483616 A/G cg24626310 chr20:25276739 ABHD12;PYGB 0.33 5.84 0.31 1.27e-8 Liver enzyme levels (alkaline phosphatase); CRC cis rs4925325 0.741 rs6142886 chr20:60511190 A/G cg06108461 chr20:60628389 TAF4 0.44 6.04 0.32 4.18e-9 Obesity-related traits; CRC cis rs9911578 1.000 rs9915935 chr17:56843048 A/G cg12560992 chr17:57184187 TRIM37 0.91 16.65 0.68 1.38e-45 Intelligence (multi-trait analysis); CRC cis rs9467711 0.659 rs13220261 chr6:26499185 C/T cg12315302 chr6:26189340 HIST1H4D 0.99 6.93 0.36 2.22e-11 Autism spectrum disorder or schizophrenia; CRC cis rs1218582 0.741 rs11264281 chr1:154867221 A/G cg06221963 chr1:154839813 KCNN3 -0.82 -16.09 -0.66 2.26e-43 Prostate cancer; CRC cis rs2463822 1.000 rs2513744 chr11:62077785 C/A cg06239285 chr11:62104954 ASRGL1 0.93 10.43 0.5 3.2800000000000002e-22 Chronic obstructive pulmonary disease-related biomarkers; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg23235142 chr7:45066841 CCM2 0.37 8.97 0.44 2.25e-17 Liver disease severity in Alagille syndrome; CRC cis rs1065852 0.526 rs7290655 chr22:42390225 C/G cg00645731 chr22:42541494 CYP2D7P1 0.4 6.85 0.35 3.59e-11 Response to serotonin reuptake inhibitors in major depressive disorder (plasma drug and metabolite levels); CRC cis rs6500395 0.925 rs6500396 chr16:48625458 A/T cg04672837 chr16:48644449 N4BP1 0.44 6.6 0.34 1.69e-10 Response to tocilizumab in rheumatoid arthritis; CRC cis rs1005277 0.579 rs2474608 chr10:38457109 C/T cg00409905 chr10:38381863 ZNF37A -0.66 -11.02 -0.52 2.92e-24 Extrinsic epigenetic age acceleration; CRC cis rs1577917 0.958 rs11752180 chr6:86573165 T/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.5 -6.46 -0.34 3.74e-10 Response to antipsychotic treatment; CRC cis rs10256972 0.568 rs1133043 chr7:1133305 C/G cg18402987 chr7:1209562 NA 0.46 6.78 0.35 5.47e-11 Longevity;Endometriosis; CRC cis rs7591163 0.883 rs16824023 chr2:228720877 G/A cg08034379 chr2:228736324 WDR69 -0.48 -6.91 -0.36 2.56e-11 Blood pressure; CRC cis rs6763159 0.566 rs35166137 chr3:59643114 C/T cg07069742 chr3:59644285 NA -0.44 -8.71 -0.43 1.51e-16 Conotruncal heart defects; CRC cis rs2243480 1.000 rs1167613 chr7:65487439 C/T cg18252515 chr7:66147081 NA -1.1 -12.3 -0.56 7.15e-29 Diabetic kidney disease; CRC trans rs2553218 0.690 rs8032415 chr15:54851945 A/G cg01442958 chr1:222817780 MIA3 0.47 6.34 0.33 7.69e-10 Immune response to smallpox vaccine (IL-6); CRC cis rs62064224 0.614 rs4794921 chr17:30742310 C/T cg09324608 chr17:30823087 MYO1D 0.33 5.64 0.3 3.73e-8 Schizophrenia; CRC cis rs57221529 0.545 rs55955015 chr5:575182 A/G cg16447950 chr5:562315 NA -0.83 -11.08 -0.52 1.83e-24 Lung disease severity in cystic fibrosis; CRC cis rs514406 0.584 rs11205997 chr1:53195271 G/C cg27535305 chr1:53392650 SCP2 0.36 6.44 0.33 4.31e-10 Monocyte count; CRC cis rs3096299 0.563 rs4600467 chr16:89562516 C/T cg01788221 chr16:89496183 ANKRD11 -0.38 -5.61 -0.3 4.34e-8 Multiple myeloma (IgH translocation); CRC cis rs7746199 0.668 rs34864796 chr6:27459923 G/A cg21204522 chr6:27730016 NA -0.67 -5.89 -0.31 9.79e-9 Gait speed in old age;Autism spectrum disorder or schizophrenia; CRC cis rs2404602 0.610 rs28823285 chr15:77050395 T/C cg03037974 chr15:76606532 NA -0.57 -8.7 -0.43 1.64e-16 Blood metabolite levels; CRC trans rs1455244 0.700 rs7229302 chr18:11508904 G/T cg17114192 chr19:2061553 NA 0.45 6.83 0.35 4.09e-11 Schizophrenia; CRC cis rs34779708 0.966 rs17591857 chr10:35499043 A/G cg03585969 chr10:35415529 CREM -0.54 -7.32 -0.37 1.89e-12 Inflammatory bowel disease;Crohn's disease; CRC cis rs4253772 0.575 rs6008684 chr22:46719100 C/G cg09491104 chr22:46646882 C22orf40 -0.45 -5.66 -0.3 3.34e-8 LDL cholesterol;Cholesterol, total; CRC cis rs7786808 0.741 rs35059736 chr7:158224692 C/T cg01191920 chr7:158217561 PTPRN2 -0.91 -17.22 -0.69 7.9e-48 Obesity-related traits; CRC cis rs10979 1.000 rs6905264 chr6:143894378 A/G cg25407410 chr6:143891975 LOC285740 -0.83 -13.73 -0.6 3.07e-34 Hypospadias; CRC cis rs1799949 1.000 rs33918839 chr17:41329172 T/C cg25072359 chr17:41440525 NA 0.46 6.91 0.36 2.52e-11 Menopause (age at onset); CRC cis rs4713118 0.587 rs9393899 chr6:28133528 G/C cg25164649 chr6:28176230 NA 0.78 9.66 0.47 1.33e-19 Parkinson's disease; CRC cis rs6696846 0.765 rs11240360 chr1:205083865 T/C cg03948781 chr1:205179583 DSTYK 0.43 6.13 0.32 2.56e-9 Red blood cell count; CRC cis rs3617 0.625 rs11719137 chr3:52876389 G/T cg07507251 chr3:52567010 NT5DC2 -0.41 -6.35 -0.33 7.02e-10 Red blood cell count;Autism spectrum disorder or schizophrenia; CRC cis rs7829975 0.714 rs11777085 chr8:8672429 G/C cg08975724 chr8:8085496 FLJ10661 0.46 6.87 0.35 3.28e-11 Mood instability; CRC cis rs6951245 1.000 rs79422648 chr7:1080241 T/C cg22907277 chr7:1156413 C7orf50 0.72 7.47 0.38 7.14e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC trans rs804280 0.564 rs4639 chr8:11644751 A/G cg06636001 chr8:8085503 FLJ10661 0.4 6.03 0.32 4.43e-9 Myopia (pathological); CRC cis rs4563143 0.663 rs10417671 chr19:29235335 T/C cg12756686 chr19:29218302 NA 0.61 9.44 0.46 6.9e-19 Methadone dose in opioid dependence; CRC cis rs896854 0.714 rs572547 chr8:95966286 A/G cg23172400 chr8:95962367 TP53INP1 0.41 6.13 0.32 2.47e-9 Type 2 diabetes; CRC cis rs2932538 0.922 rs12750621 chr1:113206502 G/C cg22162597 chr1:113214053 CAPZA1 0.64 8.54 0.43 4.93e-16 Systolic blood pressure;Diastolic blood pressure;Hypertension;Blood pressure; CRC cis rs9894429 0.546 rs9906979 chr17:79608765 A/G cg09655341 chr17:79618100 PDE6G -0.38 -6.84 -0.35 3.77e-11 Eye color traits; CRC cis rs7639513 0.545 rs55977822 chr3:12704438 C/A cg23032965 chr3:12705835 RAF1 0.54 7.27 0.37 2.69e-12 Itch intensity from mosquito bite; CRC cis rs2535633 0.631 rs2710326 chr3:52995444 T/C cg11645453 chr3:52864694 ITIH4 -0.4 -7.47 -0.38 7.52e-13 Body mass index; CRC cis rs62064224 0.589 rs2041306 chr17:30665675 T/C cg12855166 chr17:30846586 MYO1D -0.37 -6.02 -0.32 4.54e-9 Schizophrenia; CRC cis rs9443645 0.901 rs971994 chr6:79559602 G/C cg09184832 chr6:79620586 NA -0.51 -9.74 -0.47 7.02e-20 Intelligence (multi-trait analysis); CRC cis rs12681288 0.676 rs7459467 chr8:999359 C/T cg04851639 chr8:1020857 NA -0.4 -7.93 -0.4 3.39e-14 Schizophrenia; CRC cis rs12042938 0.600 rs823163 chr1:231771108 A/G cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX 0.5 7.05 0.36 1.05e-11 Neuranatomic and neurocognitive phenotypes; CRC cis rs6570726 0.791 rs401561 chr6:145835917 G/T cg05347473 chr6:146136440 FBXO30 0.4 6.23 0.32 1.45e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs1223397 1.000 rs1223397 chr6:13270945 C/G cg06879394 chr6:13274151 PHACTR1 0.49 6.18 0.32 1.87e-9 Blood pressure; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg20362559 chr2:96931853 TMEM127;CIAO1 0.48 6.67 0.35 1.06e-10 Anxiety disorder; CRC cis rs73206853 0.841 rs2339511 chr12:110789372 C/T cg12870014 chr12:110450643 ANKRD13A 0.65 6.77 0.35 6.05e-11 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC cis rs8072100 0.688 rs8075843 chr17:45442363 C/T cg08085267 chr17:45401833 C17orf57 -0.59 -9.11 -0.45 7.96e-18 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs9649213 0.574 rs7791321 chr7:97944125 G/C cg21770322 chr7:97807741 LMTK2 0.52 8.48 0.42 7.75e-16 Prostate cancer (SNP x SNP interaction); CRC cis rs10504229 0.683 rs11785258 chr8:58132893 A/G cg04204079 chr8:58130323 NA -0.45 -5.78 -0.3 1.71e-8 Developmental language disorder (linguistic errors); CRC cis rs1405069 0.809 rs1063021 chr6:36932327 A/G cg26433444 chr6:36932349 PI16 0.38 6.78 0.35 5.68e-11 Chemerin levels; CRC cis rs6456156 0.792 rs10946214 chr6:167516122 G/A cg07741184 chr6:167504864 NA 0.48 8.38 0.42 1.57e-15 Primary biliary cholangitis; CRC cis rs9534288 1.000 rs9534288 chr13:46605441 T/C cg15192986 chr13:46630673 CPB2 -0.72 -10.3 -0.49 9.63e-22 Blood protein levels; CRC cis rs7959452 0.535 rs11615712 chr12:69619736 A/T cg20891283 chr12:69753455 YEATS4 -0.77 -13.08 -0.58 9.14e-32 Blood protein levels; CRC trans rs11026407 0.967 rs7127246 chr11:22060228 C/G cg18108499 chr4:106629741 INTS12;GSTCD -0.57 -5.98 -0.31 5.72e-9 Plasma thyroid-stimulating hormone levels; CRC cis rs6570726 0.905 rs419575 chr6:145840174 A/G cg23711669 chr6:146136114 FBXO30 0.68 12.16 0.56 2.33e-28 Lobe attachment (rater-scored or self-reported); CRC cis rs9660992 0.710 rs1768586 chr1:205238275 A/G cg21643547 chr1:205240462 TMCC2 -0.45 -7.29 -0.37 2.35e-12 Mean corpuscular volume;Mean platelet volume; CRC trans rs6500957 0.920 rs17648524 chr16:7459683 C/G cg02037503 chr14:23540729 ACIN1 0.39 6.12 0.32 2.67e-9 Spherical equivalent (joint analysis main effects and education interaction); CRC cis rs6840360 0.593 rs10016160 chr4:152693998 A/G cg22705602 chr4:152727874 NA -0.34 -5.79 -0.3 1.63e-8 Intelligence (multi-trait analysis); CRC cis rs6582630 0.555 rs10880612 chr12:38509427 A/G cg13010199 chr12:38710504 ALG10B 0.48 6.46 0.34 3.84e-10 Drug-induced liver injury (flucloxacillin); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg23100370 chr2:109336342 RANBP2 0.42 6.86 0.35 3.47e-11 Liver disease severity in Alagille syndrome; CRC cis rs7258465 1.000 rs28572537 chr19:18552208 C/T cg06953865 chr19:18549723 ISYNA1 -0.38 -5.63 -0.3 3.77e-8 Breast cancer; CRC cis rs362296 0.511 rs2051558 chr4:3324886 G/A cg11522145 chr4:3412961 RGS12 -0.37 -6.19 -0.32 1.79e-9 Parental longevity (mother's age at death); CRC cis rs1552244 1.000 rs4260416 chr3:10125283 C/T cg13047869 chr3:10149882 C3orf24 0.54 7.53 0.38 4.82e-13 Alzheimer's disease; CRC cis rs6960043 0.846 rs7781710 chr7:15056045 T/A cg19272540 chr7:15055459 NA 0.23 6.29 0.33 1.03e-9 Type 2 diabetes; CRC cis rs7591163 1.000 rs6744308 chr2:228711816 T/G cg01216370 chr2:228736459 WDR69 -0.45 -5.7 -0.3 2.68e-8 Blood pressure; CRC cis rs2976388 1.000 rs2976392 chr8:143762932 G/A cg22687807 chr8:143858763 LYNX1 -0.37 -6.43 -0.33 4.41e-10 Urinary tract infection frequency; CRC cis rs7726839 0.574 rs11134148 chr5:637107 C/T cg14541582 chr5:601475 NA -0.36 -7.3 -0.37 2.21e-12 Obesity-related traits; CRC cis rs2836974 0.931 rs8132285 chr21:40655752 T/C cg11890956 chr21:40555474 PSMG1 1.11 19.05 0.72 4.69e-55 Cognitive function; CRC cis rs6743376 0.532 rs2515403 chr2:113820732 T/C cg24553058 chr2:113831203 IL1F10 0.44 7.18 0.37 4.61e-12 Inflammatory biomarkers; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg07210839 chr7:150595735 NA 0.5 6.96 0.36 1.81e-11 Response to antipsychotic treatment; CRC cis rs709400 0.663 rs7158822 chr14:103887868 C/T cg12935359 chr14:103987150 CKB -0.49 -7.91 -0.4 3.95e-14 Body mass index; CRC cis rs896854 0.624 rs9297949 chr8:95969445 A/C cg23172400 chr8:95962367 TP53INP1 -0.48 -8.3 -0.42 2.79e-15 Type 2 diabetes; CRC cis rs737008 0.922 rs1559394 chr16:11369205 A/G cg00044050 chr16:11439710 C16orf75 -0.5 -6.79 -0.35 5.23e-11 Obesity-related traits; CRC cis rs6762 0.748 rs1130663 chr11:837582 G/A cg03885332 chr11:832357 CD151 -0.43 -6.41 -0.33 4.96e-10 Mean platelet volume; CRC cis rs3736485 0.966 rs62016017 chr15:51897402 A/G cg08986416 chr15:51914746 DMXL2 -0.45 -6.38 -0.33 6.01e-10 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs9549367 0.789 rs9577220 chr13:113908294 T/A cg18105134 chr13:113819100 PROZ -0.75 -11.01 -0.52 3.14e-24 Platelet distribution width; CRC cis rs7849270 0.959 rs7032712 chr9:131893087 C/T cg13538475 chr9:131942899 NA -0.29 -5.87 -0.31 1.08e-8 Blood metabolite ratios; CRC trans rs587242 0.956 rs602272 chr1:96893914 G/A cg10631902 chr5:14652156 NA 0.44 6.84 0.35 3.84e-11 Body mass index (joint analysis main effects and physical activity interaction);Body mass index in physically inactive individuals;Body mass index; CRC cis rs7666738 0.830 rs6854703 chr4:98977586 A/T cg17366294 chr4:99064904 C4orf37 0.44 7.32 0.37 1.94e-12 Colonoscopy-negative controls vs population controls; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg09302729 chr15:91565883 VPS33B 0.43 6.17 0.32 2.04e-9 Intelligence (multi-trait analysis); CRC cis rs9322193 0.847 rs9505972 chr6:150096391 A/C cg04369109 chr6:150039330 LATS1 -0.45 -5.91 -0.31 8.44e-9 Lung cancer; CRC cis rs7586879 0.681 rs6545800 chr2:25118885 A/G cg04586622 chr2:25135609 ADCY3 0.54 10.12 0.49 4.01e-21 Body mass index; CRC trans rs925098 0.577 rs2724470 chr4:17996046 A/G cg19386303 chr19:47104863 CALM3 -0.42 -6.13 -0.32 2.58e-9 Birth weight;Height; CRC cis rs12477438 0.520 rs720229 chr2:99704273 T/C cg14399236 chr2:99771627 LIPT1;TSGA10 0.74 12.38 0.56 3.72e-29 Chronic sinus infection; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg13068082 chr3:9834448 ARPC4;TADA3 0.53 7.51 0.38 5.79e-13 Response to antipsychotic treatment; CRC cis rs12497850 0.931 rs4974079 chr3:48906469 T/G cg20833759 chr3:49053208 WDR6;DALRD3 0.53 9.14 0.45 6.55e-18 Parkinson's disease; CRC cis rs9462846 0.959 rs9462843 chr6:42856499 T/G cg02353165 chr6:42928485 GNMT 0.47 5.67 0.3 3.13e-8 Blood protein levels; CRC cis rs11098499 0.863 rs1010740 chr4:120463409 C/T cg09307838 chr4:120376055 NA -0.66 -10.08 -0.49 5.33e-21 Corneal astigmatism; CRC cis rs12762955 0.519 rs10795306 chr10:1019138 A/T cg19847866 chr10:1019161 NA 0.41 5.9 0.31 8.99e-9 Response to angiotensin II receptor blocker therapy; CRC cis rs10504229 0.775 rs17804840 chr8:58157045 C/T cg11062466 chr8:58055876 NA 0.45 6.01 0.31 4.87e-9 Developmental language disorder (linguistic errors); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg07388806 chr6:7108895 RREB1 0.47 6.37 0.33 6.25e-10 Response to antipsychotic treatment; CRC cis rs2032447 0.672 rs9379811 chr6:25955197 G/C cg12310025 chr6:25882481 NA -0.55 -7.99 -0.4 2.32e-14 Intelligence (multi-trait analysis); CRC cis rs9648716 1.000 rs7792984 chr7:140566243 G/A cg10747023 chr7:140774559 NA 0.44 5.67 0.3 3.15e-8 Type 2 diabetes; CRC cis rs7927771 0.864 rs2293580 chr11:47440283 T/A cg20135002 chr11:47629003 NA 0.34 5.69 0.3 2.83e-8 Subjective well-being; CRC cis rs6740322 0.841 rs10210507 chr2:43556636 G/T cg06169590 chr2:43455088 ZFP36L2;LOC100129726 -0.62 -7.56 -0.38 3.93e-13 Coronary artery disease; CRC trans rs61931739 0.500 rs10844844 chr12:34380350 G/T cg26384229 chr12:38710491 ALG10B 0.63 8.43 0.42 1.09e-15 Morning vs. evening chronotype; CRC cis rs2836974 0.836 rs8129355 chr21:40579869 A/G cg17971929 chr21:40555470 PSMG1 0.83 11.88 0.55 2.55e-27 Cognitive function; CRC cis rs7666738 0.791 rs62318907 chr4:99037120 C/T cg17366294 chr4:99064904 C4orf37 0.45 7.59 0.39 3.38e-13 Colonoscopy-negative controls vs population controls; CRC cis rs7666738 0.830 rs4699595 chr4:99012827 A/G cg17366294 chr4:99064904 C4orf37 0.44 7.35 0.38 1.55e-12 Colonoscopy-negative controls vs population controls; CRC trans rs783540 0.967 rs783526 chr15:83285795 C/A cg18393722 chr15:85113863 UBE2QP1 -0.37 -6.15 -0.32 2.21e-9 Schizophrenia; CRC cis rs7937682 0.855 rs539693 chr11:111477387 A/G cg19812747 chr11:111475976 SIK2 -0.59 -10.14 -0.49 3.31e-21 Primary sclerosing cholangitis; CRC cis rs11105298 0.891 rs4842661 chr12:89930399 A/G cg08166232 chr12:89918718 WDR51B;GALNT4 -0.58 -6.98 -0.36 1.61e-11 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; CRC cis rs2204008 0.729 rs2892365 chr12:38446760 G/C cg13010199 chr12:38710504 ALG10B -0.46 -6.54 -0.34 2.31e-10 Bladder cancer; CRC cis rs9660180 0.967 rs9660106 chr1:1797947 A/G cg23982607 chr1:1823379 GNB1 -0.91 -16.67 -0.68 1.17e-45 Body mass index; CRC cis rs1153858 1.000 rs12437887 chr15:45669094 G/A cg10760299 chr15:45669010 GATM 0.5 7.73 0.39 1.29e-13 Homoarginine levels; CRC cis rs8078723 0.866 rs3935280 chr17:38189055 A/G cg17467752 chr17:38218738 THRA -0.75 -12.29 -0.56 7.82e-29 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); CRC cis rs6499255 1.000 rs11644838 chr16:69812705 G/C cg15192750 chr16:69999425 NA 0.57 7.37 0.38 1.39e-12 IgE levels; CRC cis rs77633900 0.772 rs157760 chr15:76800260 A/G cg21673338 chr15:77095150 SCAPER -0.74 -6.93 -0.36 2.25e-11 Non-glioblastoma glioma;Glioma; CRC cis rs17401966 1.000 rs4845934 chr1:10468946 G/A cg19773385 chr1:10388646 KIF1B -0.57 -7.99 -0.4 2.25e-14 Hepatocellular carcinoma; CRC trans rs9329221 0.506 rs6993610 chr8:10330994 C/G cg08975724 chr8:8085496 FLJ10661 -0.4 -6.0 -0.31 5.16e-9 Neuroticism; CRC cis rs6815814 0.950 rs55903115 chr4:38786474 C/A cg06935464 chr4:38784597 TLR10 0.65 6.92 0.36 2.38e-11 Breast cancer; CRC cis rs4285028 0.948 rs2332033 chr3:121699548 C/T cg20356878 chr3:121714668 ILDR1 -0.47 -6.84 -0.35 3.92e-11 Multiple sclerosis; CRC cis rs9443645 0.869 rs9343863 chr6:79752792 T/C cg09184832 chr6:79620586 NA -0.51 -9.22 -0.45 3.68e-18 Intelligence (multi-trait analysis); CRC cis rs933688 1.000 rs10045280 chr5:90717675 T/A cg26981201 chr5:90679533 LOC100129716;ARRDC3 1.03 18.15 0.71 1.63e-51 Smoking behavior; CRC cis rs921968 0.643 rs2243911 chr2:219529348 C/T cg02176678 chr2:219576539 TTLL4 -0.48 -7.63 -0.39 2.6e-13 Mean corpuscular hemoglobin concentration; CRC cis rs4243830 0.737 rs11581831 chr1:6609958 C/T cg05709478 chr1:6581295 PLEKHG5 -0.57 -6.81 -0.35 4.6e-11 Body mass index; CRC cis rs35264875 1.000 rs35264875 chr11:68846399 A/T cg23740940 chr11:68924746 NA 0.43 5.64 0.3 3.71e-8 Blond vs. brown hair color; CRC cis rs1044826 0.692 rs295484 chr3:139231782 A/G cg00490450 chr3:139108681 COPB2 -0.43 -6.42 -0.33 4.72e-10 Obesity-related traits; CRC cis rs8017423 0.647 rs12883844 chr14:90820519 T/C cg14092571 chr14:90743983 NA 0.39 5.98 0.31 5.81e-9 Mortality in heart failure; CRC cis rs7552404 1.000 rs7534754 chr1:76185308 G/A cg03433033 chr1:76189801 ACADM 0.81 11.23 0.53 5.36e-25 Blood metabolite levels;Acylcarnitine levels; CRC cis rs6502050 0.835 rs4789676 chr17:80123078 C/T cg11859384 chr17:80120422 CCDC57 -0.36 -5.75 -0.3 2.06e-8 Life satisfaction; CRC cis rs7399018 0.739 rs6580811 chr12:51612501 T/C cg25754956 chr12:51612065 POU6F1 0.83 11.17 0.52 9.27e-25 Cisplatin-induced ototoxicity; CRC cis rs13631 0.728 rs7466635 chr9:139980417 T/C cg15396367 chr9:139972779 UAP1L1 -0.56 -8.85 -0.44 5.66e-17 Cerebrospinal fluid biomarker levels; CRC cis rs2836974 0.897 rs2026265 chr21:40595517 G/A cg11644478 chr21:40555479 PSMG1 0.79 12.03 0.55 7.39e-28 Cognitive function; CRC cis rs4713118 0.826 rs2893929 chr6:27738732 A/T cg03623178 chr6:28175578 NA 0.75 8.28 0.42 3.23e-15 Parkinson's disease; CRC cis rs12995491 0.731 rs34991383 chr2:88500337 T/G cg07952391 chr2:88470173 THNSL2 -0.44 -6.44 -0.33 4.27e-10 Response to metformin (IC50); CRC trans rs2727020 0.658 rs4980442 chr11:49445016 G/T cg21153622 chr11:89784906 NA -0.37 -6.03 -0.32 4.36e-9 Coronary artery disease; CRC trans rs2055729 0.710 rs10104236 chr8:9740292 G/C cg06636001 chr8:8085503 FLJ10661 -0.51 -6.54 -0.34 2.32e-10 Multiple myeloma (hyperdiploidy); CRC cis rs6502050 0.805 rs11077970 chr17:80085916 C/T cg22110888 chr17:80059540 CCDC57 -0.41 -6.39 -0.33 5.76e-10 Life satisfaction; CRC cis rs12594515 1.000 rs8032361 chr15:45988553 T/C cg06207120 chr15:45996521 NA 0.32 7.75 0.39 1.14e-13 Waist circumference;Weight; CRC cis rs1008375 0.966 rs2286773 chr4:17616214 C/A cg04450456 chr4:17643702 FAM184B 0.35 5.66 0.3 3.34e-8 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs35110281 0.667 rs7282405 chr21:45123611 C/G cg01579765 chr21:45077557 HSF2BP -0.35 -6.5 -0.34 2.91e-10 Mean corpuscular volume; CRC cis rs6570726 0.791 rs436156 chr6:145874873 A/G cg13319975 chr6:146136371 FBXO30 -0.45 -6.59 -0.34 1.74e-10 Lobe attachment (rater-scored or self-reported); CRC cis rs3018066 0.867 rs6836198 chr4:107052107 G/A cg01869342 chr4:106983673 TBCK 0.37 5.72 0.3 2.4e-8 Cancer; CRC cis rs4474465 0.850 rs11237537 chr11:78248397 C/T cg02023728 chr11:77925099 USP35 0.36 5.84 0.31 1.23e-8 Alzheimer's disease (survival time); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg27006027 chr19:33165562 ANKRD27;RGS9BP 0.41 6.22 0.32 1.51e-9 Intelligence (multi-trait analysis); CRC cis rs8180040 0.967 rs4858890 chr3:47405456 A/G cg02527881 chr3:46936655 PTH1R 0.34 6.14 0.32 2.42e-9 Colorectal cancer; CRC cis rs713477 0.524 rs2341538 chr14:55895174 C/G cg13175173 chr14:55914753 NA 0.47 7.56 0.38 4.02e-13 Pediatric bone mineral content (femoral neck); CRC cis rs826838 0.967 rs11183577 chr12:38781887 A/G cg26384229 chr12:38710491 ALG10B 0.75 10.51 0.5 1.77e-22 Heart rate; CRC cis rs58688157 0.660 rs7117022 chr11:583787 T/C cg16486109 chr11:613632 IRF7 0.69 11.44 0.53 9.43e-26 Systemic lupus erythematosus; CRC cis rs2153535 0.580 rs9406158 chr6:8464152 C/T cg21535247 chr6:8435926 SLC35B3 0.49 7.4 0.38 1.14e-12 Motion sickness; CRC cis rs736408 0.540 rs4687637 chr3:52634092 C/T cg15147215 chr3:52552868 STAB1 -0.64 -10.91 -0.52 7.55e-24 Bipolar disorder; CRC cis rs847577 0.609 rs34320230 chr7:97785500 C/T cg00277769 chr7:97922759 BAIAP2L1 -0.4 -6.68 -0.35 1.02e-10 Breast cancer; CRC cis rs9303401 0.659 rs34275691 chr17:56736640 A/T cg10487724 chr17:56770010 TEX14;RAD51C 0.78 9.63 0.47 1.74e-19 Cognitive test performance; CRC cis rs7618501 0.602 rs2071207 chr3:50159844 T/C cg05623727 chr3:50126028 RBM5 -0.44 -7.52 -0.38 5.3e-13 Intelligence (multi-trait analysis); CRC cis rs9443645 0.901 rs10943612 chr6:79698380 C/T cg05283184 chr6:79620031 NA -0.61 -9.64 -0.47 1.54e-19 Intelligence (multi-trait analysis); CRC cis rs10450586 0.863 rs7937389 chr11:27298451 C/T cg10370305 chr11:27303972 NA 0.38 6.23 0.32 1.42e-9 Total body bone mineral density; CRC cis rs372883 0.600 rs2832295 chr21:30739843 C/T cg08807101 chr21:30365312 RNF160 0.59 8.46 0.42 9.13e-16 Pancreatic cancer; CRC cis rs1568889 0.592 rs7110074 chr11:28469325 G/T cg06544937 chr11:28130018 METT5D1;KIF18A 0.62 7.13 0.37 6.26e-12 Bipolar disorder; CRC cis rs6424115 0.729 rs1737362 chr1:24054800 T/C cg15997130 chr1:24165203 NA 0.7 10.0 0.48 9.94e-21 Immature fraction of reticulocytes; CRC cis rs7811142 0.943 rs10241492 chr7:99994813 A/G cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.14 16.37 0.67 1.82e-44 Platelet count; CRC cis rs281302 0.621 rs12439443 chr15:47733445 G/A cg13159054 chr15:47721715 NA -0.43 -6.68 -0.35 1.01e-10 Educational attainment (years of education);Cognitive ability (multi-trait analysis); CRC cis rs55794721 0.509 rs2375313 chr1:25748235 G/A cg27572855 chr1:25598939 RHD 0.36 6.57 0.34 1.94e-10 Plateletcrit;Mean corpuscular volume; CRC cis rs9527 0.641 rs4919684 chr10:104587024 A/G cg04362960 chr10:104952993 NT5C2 0.64 8.16 0.41 7.15e-15 Arsenic metabolism; CRC cis rs12701220 0.655 rs7799656 chr7:1140515 C/T cg26769984 chr7:1090371 C7orf50 0.51 7.15 0.37 5.8e-12 Bronchopulmonary dysplasia; CRC cis rs73195822 0.614 rs55680931 chr12:111218297 A/T cg12870014 chr12:110450643 ANKRD13A 0.7 5.71 0.3 2.52e-8 Itch intensity from mosquito bite; CRC cis rs1862618 0.853 rs2113079 chr5:56157951 A/G cg24531977 chr5:56204891 C5orf35 -0.81 -10.97 -0.52 4.69e-24 Initial pursuit acceleration; CRC cis rs12188164 0.930 rs72717440 chr5:449701 A/T cg17553881 chr5:443987 EXOC3;C5orf55 -0.37 -7.9 -0.4 4.09e-14 Cystic fibrosis severity; CRC trans rs3793917 0.901 rs58077526 chr10:124230024 A/C cg14854287 chr5:423894 AHRR -0.4 -6.13 -0.32 2.57e-9 Age-related macular degeneration; CRC cis rs12476592 0.602 rs262479 chr2:63872479 C/T cg10828910 chr2:63850056 LOC388955 0.49 6.11 0.32 2.88e-9 Childhood ear infection; CRC cis rs1552244 0.810 rs7612908 chr3:10089148 A/G cg00166722 chr3:10149974 C3orf24 0.7 9.53 0.46 3.69e-19 Alzheimer's disease; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg25229157 chr1:51426110 FAF1 0.48 7.07 0.36 9.34e-12 Intelligence (multi-trait analysis); CRC cis rs7945705 0.869 rs11042154 chr11:9029700 A/G cg21881798 chr11:8931708 C11orf17;ST5 -0.61 -9.02 -0.45 1.59e-17 Hemoglobin concentration; CRC cis rs9291683 0.588 rs17247314 chr4:10004743 C/G cg00071950 chr4:10020882 SLC2A9 0.66 12.16 0.56 2.29e-28 Bone mineral density; CRC trans rs10983614 1.000 rs7867776 chr9:120072627 A/G cg11781535 chr10:38893821 NA 0.47 6.6 0.34 1.63e-10 Survival in pancreatic cancer; CRC cis rs2739330 0.753 rs4822452 chr22:24254363 C/T cg18538332 chr22:24372958 LOC391322 -0.71 -11.35 -0.53 2.02e-25 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs1552244 1.000 rs9811771 chr3:10133949 A/G cg02579736 chr3:10068473 FANCD2;CIDECP 0.93 12.52 0.57 1.08e-29 Alzheimer's disease; CRC cis rs172166 0.516 rs1225618 chr6:28129713 A/C cg10876282 chr6:28092338 ZSCAN16 0.4 5.81 0.31 1.47e-8 Cardiac Troponin-T levels; CRC cis rs10256972 0.685 rs10263665 chr7:1110628 A/G cg22907277 chr7:1156413 C7orf50 0.43 6.18 0.32 1.85e-9 Longevity;Endometriosis; CRC cis rs4665809 1.000 rs6546726 chr2:26275116 A/G cg04944784 chr2:26401820 FAM59B -0.6 -7.72 -0.39 1.37e-13 Gut microbiome composition (summer); CRC cis rs10504073 0.647 rs6997703 chr8:49998364 T/C cg00325661 chr8:49890786 NA 0.53 9.35 0.46 1.43e-18 Blood metabolite ratios; CRC cis rs853679 0.550 rs1150689 chr6:28165099 T/C cg23161317 chr6:28129485 ZNF389 0.46 6.02 0.31 4.79e-9 Depression; CRC cis rs7552404 1.000 rs7552404 chr1:76135946 A/G cg10523679 chr1:76189770 ACADM 0.83 11.51 0.54 5.3e-26 Blood metabolite levels;Acylcarnitine levels; CRC trans rs1008375 0.863 rs10003291 chr4:17600728 A/C cg19590445 chr5:174155345 MSX2 0.46 6.32 0.33 8.48e-10 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs11148252 0.583 rs9536048 chr13:52958788 T/C cg02158880 chr13:53174818 NA 0.48 6.31 0.33 8.93e-10 Lewy body disease; CRC cis rs77633900 0.614 rs2170998 chr15:77007159 C/T cg21673338 chr15:77095150 SCAPER 0.68 6.97 0.36 1.77e-11 Non-glioblastoma glioma;Glioma; CRC trans rs7395662 0.782 rs66468703 chr11:48738773 T/C cg21153622 chr11:89784906 NA -0.48 -7.67 -0.39 2.02e-13 HDL cholesterol; CRC cis rs13191362 1.000 rs13220048 chr6:163004325 T/A cg21926612 chr6:163149169 PACRG;PARK2 0.8 11.15 0.52 1.08e-24 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs2204008 0.837 rs7315255 chr12:37949279 G/A cg13010199 chr12:38710504 ALG10B 0.45 5.74 0.3 2.19e-8 Bladder cancer; CRC cis rs4820539 1.000 rs916585 chr22:23469438 G/A cg14186256 chr22:23484241 RTDR1 0.92 18.38 0.71 2.04e-52 Bone mineral density; CRC cis rs4665809 0.652 rs6728090 chr2:26524726 C/T cg27170947 chr2:26402098 FAM59B -0.42 -5.63 -0.3 3.86e-8 Gut microbiome composition (summer); CRC cis rs7412746 0.658 rs6656535 chr1:150940357 G/T cg17724175 chr1:150552817 MCL1 0.47 7.0 0.36 1.46e-11 Melanoma; CRC cis rs72634258 0.945 rs12757968 chr1:8106201 A/G cg26816564 chr1:7831052 VAMP3 0.58 6.32 0.33 8.47e-10 Inflammatory bowel disease; CRC cis rs13191362 1.000 rs13209100 chr6:163159350 C/T cg23758597 chr6:163146217 PARK2 -0.54 -6.34 -0.33 7.48e-10 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs875971 0.862 rs6960446 chr7:65733259 A/G cg18252515 chr7:66147081 NA 0.4 5.71 0.3 2.52e-8 Aortic root size; CRC cis rs8062405 0.755 rs62034325 chr16:28538640 A/G cg16576597 chr16:28551801 NUPR1 0.53 7.76 0.39 1.05e-13 Cognitive ability (multi-trait analysis);Cognitive ability; CRC cis rs270601 0.633 rs733300 chr5:131572243 A/G cg18758796 chr5:131593413 PDLIM4 0.52 8.88 0.44 4.42e-17 Acylcarnitine levels; CRC cis rs6912958 0.781 rs7761814 chr6:88188309 G/A cg12350822 chr6:88032061 C6orf162;GJB7 -0.32 -6.11 -0.32 2.88e-9 Monocyte percentage of white cells; CRC cis rs10493773 0.609 rs3753789 chr1:86174814 T/C cg00734567 chr1:86172782 ZNHIT6 -0.49 -7.41 -0.38 1.08e-12 Urate levels in overweight individuals; CRC cis rs305851 0.875 rs74335065 chr6:39759083 T/C cg02386599 chr6:39769542 DAAM2 0.37 5.83 0.31 1.36e-8 Lobe attachment (rater-scored or self-reported); CRC cis rs796364 0.906 rs281766 chr2:200820505 T/G cg23649088 chr2:200775458 C2orf69 0.54 5.71 0.3 2.49e-8 Schizophrenia; CRC cis rs9435341 0.965 rs1762482 chr1:107599002 A/C cg14671364 chr1:107599128 PRMT6 -0.56 -7.89 -0.4 4.42e-14 Facial morphology (factor 21, depth of nasal alae); CRC cis rs6570726 0.791 rs385729 chr6:145855465 T/C cg13319975 chr6:146136371 FBXO30 -0.45 -6.78 -0.35 5.5e-11 Lobe attachment (rater-scored or self-reported); CRC cis rs7586879 0.828 rs13428789 chr2:25087643 C/T cg22495460 chr2:25135724 ADCY3 -0.77 -12.75 -0.58 1.5e-30 Body mass index; CRC cis rs9818758 0.607 rs9311439 chr3:49310408 A/G cg00383909 chr3:49044727 WDR6 1.1 10.48 0.5 2.33e-22 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; CRC cis rs7944584 0.611 rs10838696 chr11:47363285 A/G cg20307385 chr11:47447363 PSMC3 -0.7 -9.41 -0.46 9.11e-19 Fasting blood glucose;Fasting blood glucose (BMI interaction); CRC cis rs832540 0.806 rs10039322 chr5:56260259 A/C cg24531977 chr5:56204891 C5orf35 -0.45 -7.11 -0.36 7.23e-12 Coronary artery disease; CRC cis rs73206853 0.841 rs56076213 chr12:110572913 G/A cg12870014 chr12:110450643 ANKRD13A 0.79 8.0 0.4 2.21e-14 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC cis rs2732480 0.538 rs1387260 chr12:48703091 A/C cg24011408 chr12:48396354 COL2A1 0.45 6.24 0.33 1.34e-9 Hemoglobin concentration;Red blood cell count;Hematocrit; CRC cis rs9611565 0.659 rs11090049 chr22:41915329 C/T cg03806693 chr22:41940476 POLR3H -1.1 -13.69 -0.6 4.34e-34 Vitiligo; CRC trans rs11098499 0.865 rs9996417 chr4:120295862 T/C cg25214090 chr10:38739885 LOC399744 0.63 9.77 0.47 5.88e-20 Corneal astigmatism; CRC cis rs854765 0.583 rs2350977 chr17:17802779 A/G cg09796270 chr17:17721594 SREBF1 0.55 9.46 0.46 6e-19 Total body bone mineral density; CRC cis rs881375 1.000 rs1609810 chr9:123642351 C/T cg09419670 chr9:123605666 PSMD5;LOC253039 0.58 8.49 0.42 7.32e-16 Rheumatoid arthritis; CRC cis rs17253792 0.822 rs113692713 chr14:56087424 C/T cg01858014 chr14:56050164 KTN1 -0.87 -7.21 -0.37 3.97e-12 Putamen volume; CRC cis rs4654899 1.000 rs7535895 chr1:21439239 T/A cg02927042 chr1:21476669 EIF4G3 -0.51 -8.11 -0.41 1.03e-14 Superior frontal gyrus grey matter volume; CRC cis rs67478160 0.679 rs8011109 chr14:104279974 G/A cg01849466 chr14:104193079 ZFYVE21 -0.46 -8.11 -0.41 1.01e-14 Schizophrenia; CRC cis rs1865760 0.865 rs9467650 chr6:25958235 A/G cg16482183 chr6:26056742 HIST1H1C 0.54 7.99 0.4 2.27e-14 Height; CRC cis rs6840360 0.607 rs1561918 chr4:152446832 T/A cg09659197 chr4:152720779 NA 0.33 6.67 0.35 1.08e-10 Intelligence (multi-trait analysis); CRC cis rs2032447 1.000 rs2032447 chr6:26044369 A/G cg03517284 chr6:25882590 NA -0.44 -6.19 -0.32 1.75e-9 Intelligence (multi-trait analysis); CRC cis rs4862750 0.914 rs1991256 chr4:187875330 A/G cg06074448 chr4:187884817 NA -0.6 -11.25 -0.53 4.69e-25 Lobe attachment (rater-scored or self-reported); CRC cis rs7940866 0.845 rs10894294 chr11:130830748 G/T cg12179176 chr11:130786555 SNX19 0.59 8.85 0.44 5.39e-17 Schizophrenia; CRC cis rs561341 0.609 rs739800 chr17:30190083 T/A cg13647721 chr17:30228624 UTP6 -0.63 -7.19 -0.37 4.38e-12 Hip circumference adjusted for BMI; CRC cis rs6499255 0.951 rs689455 chr16:69761661 T/G cg15192750 chr16:69999425 NA 0.57 7.57 0.39 3.84e-13 IgE levels; CRC cis rs9914988 0.943 rs4794838 chr17:27131095 T/C cg16670446 chr17:27188758 MIR451;MIR144 0.55 8.52 0.43 5.75e-16 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs2486012 1.000 rs2906463 chr1:44330048 A/G cg12908607 chr1:44402522 ARTN -0.42 -5.7 -0.3 2.66e-8 Intelligence (multi-trait analysis); CRC cis rs10992471 0.603 rs755209 chr9:95489671 G/A cg14631576 chr9:95140430 CENPP -0.34 -5.72 -0.3 2.43e-8 Visceral adipose tissue/subcutaneous adipose tissue ratio; CRC cis rs35883536 0.647 rs2783693 chr1:101045040 C/T cg06223162 chr1:101003688 GPR88 0.35 6.42 0.33 4.76e-10 Monocyte count; CRC cis rs870825 0.655 rs6844929 chr4:185653809 C/G cg04058563 chr4:185651563 MLF1IP -0.76 -9.02 -0.45 1.62e-17 Blood protein levels; CRC cis rs7618915 0.508 rs13065851 chr3:52644836 T/A cg05573699 chr3:52720067 GNL3;PBRM1 -0.44 -6.26 -0.33 1.18e-9 Bipolar disorder; CRC cis rs28386778 0.897 rs1470697 chr17:61799840 T/C cg06873352 chr17:61820015 STRADA 0.79 14.79 0.63 2.66e-38 Prudent dietary pattern; CRC cis rs3741404 0.620 rs2236648 chr11:63964657 C/T cg15107132 chr11:63991130 FERMT3 -0.37 -6.07 -0.32 3.46e-9 Platelet count; CRC cis rs7584330 0.554 rs3751105 chr2:238428459 G/A cg14458575 chr2:238380390 NA 0.52 7.08 0.36 8.63e-12 Prostate cancer; CRC cis rs4917300 0.605 rs4917279 chr8:143095690 C/T cg25363559 chr8:143086065 NA -0.33 -6.11 -0.32 2.82e-9 Amyotrophic lateral sclerosis; CRC cis rs7224685 0.501 rs4790559 chr17:4010478 G/T cg21851534 chr17:3907994 ZZEF1 -0.39 -6.48 -0.34 3.36e-10 Type 2 diabetes; CRC cis rs7586879 0.828 rs7597157 chr2:25089166 C/T cg22495460 chr2:25135724 ADCY3 -0.83 -13.86 -0.61 1.02e-34 Body mass index; CRC cis rs4481887 0.927 rs9651176 chr1:248447343 A/G cg00666640 chr1:248458726 OR2T12 0.54 9.59 0.47 2.22e-19 Common traits (Other); CRC cis rs6693567 0.516 rs3850844 chr1:150413940 G/T cg15654264 chr1:150340011 RPRD2 0.42 6.25 0.33 1.29e-9 Migraine; CRC cis rs9469578 1.000 rs16869458 chr6:33714639 C/T cg18708504 chr6:33715942 IP6K3 0.66 7.56 0.38 4e-13 Phosphorus levels; CRC cis rs9847710 0.967 rs2564931 chr3:53020559 G/A cg18404041 chr3:52824283 ITIH1 0.31 6.09 0.32 3.1e-9 Ulcerative colitis; CRC cis rs9381040 0.655 rs9381032 chr6:41044986 A/T cg25110423 chr6:41068646 NFYA;LOC221442 -0.4 -6.02 -0.31 4.73e-9 Alzheimer's disease (late onset); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg12857488 chr7:149195092 ZNF746 0.36 6.01 0.31 4.79e-9 Liver disease severity in Alagille syndrome; CRC cis rs56283067 0.810 rs10948155 chr6:44687957 T/C cg18551225 chr6:44695536 NA -0.4 -5.79 -0.3 1.63e-8 Total body bone mineral density; CRC cis rs2921073 0.605 rs2976933 chr8:8254875 A/G cg08975724 chr8:8085496 FLJ10661 0.46 6.54 0.34 2.32e-10 Parkinson's disease; CRC trans rs7448080 0.702 rs2088903 chr5:123299735 G/C cg23202058 chr4:185139648 ENPP6 0.63 6.49 0.34 3.21e-10 Alcohol dependence (age at onset); CRC cis rs1552244 1.000 rs7619340 chr3:10108178 C/T cg08888203 chr3:10149979 C3orf24 0.73 9.99 0.48 1.03e-20 Alzheimer's disease; CRC cis rs7224737 1.000 rs8074708 chr17:40286354 A/G cg02450064 chr17:40260053 DHX58 0.42 6.08 0.32 3.31e-9 Fibrinogen levels; CRC cis rs4523957 0.579 rs2270478 chr17:2089848 G/A cg16513277 chr17:2031491 SMG6 -0.59 -9.87 -0.48 2.66e-20 Autism spectrum disorder or schizophrenia;Schizophrenia; CRC cis rs12594515 1.000 rs12906442 chr15:45985254 C/A cg19682013 chr15:45996608 NA 0.33 6.83 0.35 4.04e-11 Waist circumference;Weight; CRC cis rs4731207 0.596 rs6959632 chr7:124691046 A/T cg23710748 chr7:124431027 NA -0.39 -6.22 -0.32 1.54e-9 Cutaneous malignant melanoma; CRC cis rs329648 0.667 rs11223616 chr11:133772838 C/T cg18057887 chr11:133800913 IGSF9B 0.45 5.6 0.3 4.43e-8 Parkinson's disease; CRC cis rs812925 0.537 rs10865324 chr2:61621307 G/A cg10580144 chr2:61372316 C2orf74 -0.33 -7.18 -0.37 4.79e-12 Immature fraction of reticulocytes; CRC trans rs6601327 0.585 rs1394 chr8:9511654 G/A cg16141378 chr3:129829833 LOC729375 0.42 6.15 0.32 2.25e-9 Multiple myeloma (hyperdiploidy); CRC cis rs853679 0.517 rs9368558 chr6:28133306 A/G cg12273811 chr6:28175739 NA 0.73 9.16 0.45 5.8e-18 Depression; CRC trans rs62295889 0.602 rs62293665 chr4:12538601 T/A cg03490839 chr16:73082051 ZFHX3 0.58 6.06 0.32 3.82e-9 Obesity-related traits; CRC cis rs13108904 0.557 rs1680033 chr4:1243404 C/T cg23123621 chr4:1343375 KIAA1530 -0.36 -5.85 -0.31 1.19e-8 Obesity-related traits; CRC cis rs4665809 0.590 rs3806515 chr2:26466975 C/T cg08067268 chr2:26466485 HADHB;HADHA 0.65 8.34 0.42 2e-15 Gut microbiome composition (summer); CRC cis rs2228479 0.702 rs17226841 chr16:89828484 C/T cg06656553 chr16:89960601 TCF25 -0.7 -5.76 -0.3 1.93e-8 Skin colour saturation; CRC cis rs769267 0.895 rs2916074 chr19:19530270 C/T cg02546618 chr19:19431379 KIAA0892;SF4 0.45 6.33 0.33 8.22e-10 Tonsillectomy; CRC cis rs11628318 0.660 rs12887323 chr14:103083322 T/C cg12046867 chr14:103022105 NA -0.77 -9.19 -0.45 4.59e-18 Platelet count; CRC cis rs10540 1.000 rs35231079 chr11:515224 G/A cg03352830 chr11:487213 PTDSS2 0.65 7.42 0.38 1.03e-12 Body mass index; CRC trans rs9858542 0.953 rs11715915 chr3:49455330 A/G cg21582582 chr3:182698605 DCUN1D1 0.49 6.26 0.33 1.21e-9 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC trans rs7615952 0.546 rs2922194 chr3:125332263 G/A cg00769240 chr8:12517080 NA -0.66 -7.28 -0.37 2.51e-12 Blood pressure (smoking interaction); CRC cis rs7772486 0.790 rs4435956 chr6:146232403 G/C cg23711669 chr6:146136114 FBXO30 -0.72 -12.64 -0.57 3.92e-30 Lobe attachment (rater-scored or self-reported); CRC cis rs2075371 0.933 rs1868784 chr7:133945932 A/G cg20476274 chr7:133979776 SLC35B4 0.74 12.81 0.58 9.33e-31 Mean platelet volume; CRC cis rs10256972 0.591 rs10229680 chr7:1158565 C/T cg07092213 chr7:1199455 ZFAND2A -0.43 -5.95 -0.31 6.68e-9 Longevity;Endometriosis; CRC cis rs9908158 1 rs9908158 chr17:33890083 T/C cg05299278 chr17:33885742 SLFN14 -0.42 -6.33 -0.33 7.95e-10 Platelet count;Platelet distribution width; CRC cis rs9916302 0.904 rs10221223 chr17:37489100 T/G cg03013999 chr17:37608204 MED1 -0.46 -7.02 -0.36 1.25e-11 Glomerular filtration rate (creatinine); CRC cis rs7809950 0.817 rs10224503 chr7:107075569 A/C cg23024343 chr7:107201750 COG5 -0.7 -9.71 -0.47 8.86e-20 Coronary artery disease; CRC cis rs9649213 0.593 rs12728 chr7:97922851 C/T cg00277769 chr7:97922759 BAIAP2L1 -0.63 -11.07 -0.52 1.95e-24 Prostate cancer (SNP x SNP interaction); CRC cis rs910316 0.967 rs4899545 chr14:75568138 A/G cg08847533 chr14:75593920 NEK9 0.94 18.63 0.72 2.21e-53 Height; CRC cis rs2806561 0.765 rs2806556 chr1:23502850 G/A cg12483005 chr1:23474871 LUZP1 0.51 7.41 0.38 1.06e-12 Height; CRC cis rs12926788 0.542 rs11862971 chr16:24767574 C/A cg06028605 chr16:24865363 SLC5A11 0.6 9.96 0.48 1.33e-20 Ejection fraction in Tripanosoma cruzi seropositivity; CRC trans rs7615952 0.512 rs2922175 chr3:125361360 T/C cg00769240 chr8:12517080 NA -0.74 -10.23 -0.49 1.64e-21 Blood pressure (smoking interaction); CRC cis rs175714 0.845 rs175706 chr14:75976200 G/A cg01624173 chr14:75981868 NA 0.52 8.53 0.43 5.43e-16 Lymphocyte counts; CRC cis rs877282 0.898 rs35743076 chr10:758991 C/T cg17470449 chr10:769945 NA 0.64 8.66 0.43 2.14e-16 Uric acid levels; CRC cis rs6743376 0.556 rs2515402 chr2:113820580 C/A cg24553058 chr2:113831203 IL1F10 0.44 7.18 0.37 4.61e-12 Inflammatory biomarkers; CRC cis rs8180040 0.620 rs6414435 chr3:47121140 A/G cg02527881 chr3:46936655 PTH1R -0.34 -5.91 -0.31 8.59e-9 Colorectal cancer; CRC cis rs9811920 0.609 rs793462 chr3:99616461 G/A cg07805332 chr3:99536008 MIR548G;C3orf26 -0.51 -7.68 -0.39 1.84e-13 Axial length; CRC cis rs826838 1.000 rs826886 chr12:39095797 A/G cg26384229 chr12:38710491 ALG10B 0.6 9.24 0.45 3.1e-18 Heart rate; CRC cis rs12024301 0.557 rs76792069 chr1:183654011 G/A cg11505048 chr1:183622726 RGL1;APOBEC4 0.71 6.24 0.33 1.33e-9 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs10946940 0.965 rs6915266 chr6:27528643 G/A cg02683197 chr6:28174875 NA -0.54 -7.51 -0.38 5.63e-13 Systemic lupus erythematosus; CRC cis rs9875589 0.957 rs62234598 chr3:13964610 G/A cg19554555 chr3:13937349 NA 0.5 7.21 0.37 3.91e-12 Ovarian reserve; CRC cis rs6740322 0.748 rs6544634 chr2:43471528 G/C cg06169590 chr2:43455088 ZFP36L2;LOC100129726 -0.78 -9.9 -0.48 2.13e-20 Coronary artery disease; CRC cis rs2019137 0.560 rs7421852 chr2:113990261 G/A cg25243455 chr2:114033360 PAX8;LOC440839 -0.31 -7.3 -0.37 2.23e-12 Lymphocyte counts; CRC cis rs4713118 0.955 rs9368529 chr6:27684631 G/A cg26587870 chr6:27730563 NA -0.42 -6.29 -0.33 1.01e-9 Parkinson's disease; CRC cis rs4481887 0.927 rs4347240 chr1:248475403 C/G cg13385794 chr1:248469461 NA 0.38 6.61 0.34 1.55e-10 Common traits (Other); CRC trans rs6550704 0.687 rs9865314 chr3:22634337 A/G cg16975973 chr12:77459865 E2F7 -0.41 -6.12 -0.32 2.72e-9 Daytime sleep phenotypes; CRC cis rs7072216 0.763 rs942803 chr10:100168631 G/T cg26618903 chr10:100175079 PYROXD2 -0.55 -9.16 -0.45 5.81e-18 Metabolite levels; CRC cis rs8177253 0.798 rs9871148 chr3:133507509 T/C cg11941060 chr3:133502564 NA -0.65 -11.21 -0.53 6.44e-25 Iron status biomarkers; CRC cis rs2239547 0.618 rs3733047 chr3:52871929 A/G cg11645453 chr3:52864694 ITIH4 -0.59 -10.25 -0.49 1.43e-21 Schizophrenia; CRC cis rs780096 0.546 rs12473776 chr2:27636474 A/G cg02592271 chr2:27665507 KRTCAP3 -0.27 -6.16 -0.32 2.08e-9 Total body bone mineral density; CRC cis rs9435341 0.965 rs2335104 chr1:107583641 A/T cg14671364 chr1:107599128 PRMT6 0.49 6.92 0.36 2.36e-11 Facial morphology (factor 21, depth of nasal alae); CRC cis rs7814319 0.700 rs871798 chr8:97257982 T/C cg20787634 chr8:97240163 UQCRB -0.45 -7.34 -0.38 1.72e-12 Lung function (FVC); CRC cis rs4731207 0.565 rs6977613 chr7:124681791 G/A cg23710748 chr7:124431027 NA -0.39 -6.22 -0.32 1.54e-9 Cutaneous malignant melanoma; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg12066438 chr12:98909292 TMPO;LOC100128191 0.4 6.03 0.32 4.43e-9 Intelligence (multi-trait analysis); CRC cis rs10924970 0.934 rs2891026 chr1:235429907 A/C cg26050004 chr1:235667680 B3GALNT2 0.39 5.75 0.3 2.06e-8 Asthma; CRC cis rs17592366 0.517 rs10148967 chr14:35283744 G/A cg09327582 chr14:35236912 BAZ1A 0.46 6.46 0.34 3.78e-10 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells; CRC cis rs7666738 0.830 rs13149346 chr4:99009933 C/T cg05340658 chr4:99064831 C4orf37 0.61 9.54 0.47 3.44e-19 Colonoscopy-negative controls vs population controls; CRC cis rs10256972 0.577 rs2949179 chr7:1209885 C/G cg04025307 chr7:1156635 C7orf50 0.6 9.34 0.46 1.51e-18 Longevity;Endometriosis; CRC cis rs6860806 0.507 rs582490 chr5:131710095 G/A cg27615366 chr5:131592974 PDLIM4 -0.32 -5.69 -0.3 2.77e-8 Breast cancer; CRC cis rs2882667 0.931 rs13153618 chr5:138352776 C/A cg04439458 chr5:138467593 SIL1 -0.33 -5.91 -0.31 8.35e-9 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs6860806 0.603 rs112300250 chr5:131583292 G/A cg18758796 chr5:131593413 PDLIM4 0.44 8.17 0.41 6.87e-15 Breast cancer; CRC cis rs11971779 0.618 rs10085814 chr7:139064089 A/G cg23387468 chr7:139079360 LUC7L2 0.41 7.04 0.36 1.14e-11 Diisocyanate-induced asthma; CRC cis rs2985684 1.000 rs2985684 chr14:50101682 C/G cg04989706 chr14:50066350 PPIL5 -0.51 -7.17 -0.37 4.91e-12 Carotid intima media thickness; CRC cis rs2880765 0.835 rs4842884 chr15:86035174 T/C cg17133734 chr15:86042851 AKAP13 0.43 6.73 0.35 7.69e-11 Coronary artery disease; CRC cis rs7208859 0.673 rs11652370 chr17:29097223 G/A cg13385521 chr17:29058706 SUZ12P 0.58 7.34 0.38 1.65e-12 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs9814567 1.000 rs62271514 chr3:134298554 A/G cg06109529 chr3:134205091 CEP63;ANAPC13 0.82 11.96 0.55 1.33e-27 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs2333194 0.707 rs10134224 chr14:73781943 G/T cg19682024 chr14:74008259 HEATR4;ACOT1 -0.42 -6.28 -0.33 1.05e-9 Bipolar disorder with mood-incongruent psychosis; CRC cis rs11608355 0.545 rs12818120 chr12:109901916 C/T cg05360138 chr12:110035743 NA 0.77 8.62 0.43 2.84e-16 Neuroticism; CRC cis rs6502050 0.769 rs9904237 chr17:80119664 G/A cg25804541 chr17:80189381 SLC16A3 -0.31 -5.95 -0.31 6.84e-9 Life satisfaction; CRC cis rs10540 1.000 rs116101630 chr11:506826 G/C cg21784768 chr11:537496 LRRC56 -0.64 -6.09 -0.32 3.21e-9 Body mass index; CRC cis rs8060686 0.545 rs9931987 chr16:68256639 G/A cg26727032 chr16:67993705 SLC12A4 -0.62 -8.03 -0.4 1.77e-14 HDL cholesterol;Metabolic syndrome; CRC cis rs9649213 0.593 rs6947340 chr7:97912241 A/G cg21770322 chr7:97807741 LMTK2 -0.54 -9.14 -0.45 6.73e-18 Prostate cancer (SNP x SNP interaction); CRC cis rs2204008 0.683 rs7305703 chr12:38138381 T/C cg13010199 chr12:38710504 ALG10B 0.47 6.25 0.33 1.31e-9 Bladder cancer; CRC cis rs2880765 0.546 rs11639291 chr15:86064130 G/A cg20737812 chr15:86336631 KLHL25 -0.34 -5.62 -0.3 4.13e-8 Coronary artery disease; CRC cis rs6502050 0.799 rs28376857 chr17:80104351 G/A cg19223190 chr17:80058835 NA 0.4 6.36 0.33 6.88e-10 Life satisfaction; CRC cis rs2228479 0.702 rs17233868 chr16:89803629 C/T cg06558623 chr16:89946397 TCF25 1.16 10.95 0.52 5.2e-24 Skin colour saturation; CRC trans rs916888 0.610 rs199454 chr17:44800110 G/A cg22433210 chr17:43662623 NA -0.61 -7.74 -0.39 1.21e-13 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs7615952 0.599 rs12486459 chr3:125741465 T/G cg05084668 chr3:125655381 ALG1L -0.44 -6.16 -0.32 2.09e-9 Blood pressure (smoking interaction); CRC cis rs7312933 0.607 rs7965392 chr12:42540280 G/A cg19980929 chr12:42632907 YAF2 0.45 6.51 0.34 2.86e-10 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CRC cis rs951366 1.000 rs951366 chr1:205685352 C/T cg24503407 chr1:205819492 PM20D1 0.46 6.53 0.34 2.54e-10 Menarche (age at onset); CRC cis rs3785574 0.927 rs2008018 chr17:61954471 C/T cg06601766 chr17:61851465 DDX42;CCDC47 0.52 7.36 0.38 1.46e-12 Height; CRC cis rs2404602 0.716 rs12441550 chr15:76863682 A/T cg22467129 chr15:76604101 ETFA -0.39 -6.43 -0.33 4.59e-10 Blood metabolite levels; CRC cis rs9322193 0.923 rs62441284 chr6:150072678 C/A cg13206674 chr6:150067644 NUP43 0.68 10.35 0.5 6.48e-22 Lung cancer; CRC cis rs7712401 0.755 rs27740 chr5:122204772 A/T cg18764291 chr5:122110994 SNX2 -0.41 -6.52 -0.34 2.7e-10 Mean platelet volume; CRC cis rs9462846 0.691 rs67059212 chr6:42913269 T/G cg10862848 chr6:42927986 GNMT -0.29 -6.02 -0.32 4.54e-9 Blood protein levels; CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg15617548 chr2:171785815 GORASP2 0.4 6.34 0.33 7.36e-10 Obesity-related traits; CRC cis rs4253772 0.626 rs113658408 chr22:46646019 C/G cg09491104 chr22:46646882 C22orf40 -0.48 -5.77 -0.3 1.79e-8 LDL cholesterol;Cholesterol, total; CRC trans rs7267979 0.966 rs2387885 chr20:25415224 G/A cg17903999 chr18:56338584 MALT1 0.41 6.61 0.34 1.59e-10 Liver enzyme levels (alkaline phosphatase); CRC cis rs2404602 0.647 rs11637096 chr15:76931102 T/C cg23625390 chr15:77176239 SCAPER -0.88 -13.83 -0.61 1.33e-34 Blood metabolite levels; CRC cis rs4713118 0.662 rs9380046 chr6:28030499 T/C cg03623178 chr6:28175578 NA 0.91 12.82 0.58 8.85e-31 Parkinson's disease; CRC cis rs9768139 0.708 rs10233815 chr7:158114348 C/T cg25566285 chr7:158114605 PTPRN2 0.52 8.58 0.43 3.77e-16 Calcium levels; CRC cis rs10504229 0.775 rs72650876 chr8:58161638 G/A cg05313129 chr8:58192883 C8orf71 -0.49 -6.21 -0.32 1.55e-9 Developmental language disorder (linguistic errors); CRC cis rs4844614 0.904 rs6686325 chr1:207833357 G/A cg17822947 chr1:207842917 CR1L -0.35 -5.7 -0.3 2.64e-8 LDL cholesterol; CRC cis rs763014 0.932 rs2269560 chr16:682442 A/C cg00908189 chr16:619842 PIGQ 0.63 10.12 0.49 3.85e-21 Height; CRC cis rs9796 0.870 rs8023345 chr15:41338348 T/G cg18705301 chr15:41695430 NDUFAF1 -0.36 -6.03 -0.32 4.34e-9 Menopause (age at onset); CRC cis rs11924390 0.789 rs822366 chr3:186452490 A/G cg04611788 chr3:186434169 KNG1 -0.58 -8.34 -0.42 2.04e-15 Adiponectin levels; CRC cis rs8180040 0.647 rs57756484 chr3:47239333 A/G cg02527881 chr3:46936655 PTH1R 0.35 6.11 0.32 2.83e-9 Colorectal cancer; CRC cis rs3741404 0.620 rs12787945 chr11:63977546 G/A cg06219103 chr11:63990595 FERMT3 -0.44 -6.93 -0.36 2.25e-11 Platelet count; CRC cis rs9322817 0.902 rs9391238 chr6:105197874 A/G cg02098413 chr6:105308735 HACE1 -0.36 -6.58 -0.34 1.9e-10 Thyroid stimulating hormone; CRC cis rs35110281 0.627 rs11701746 chr21:44975137 C/T cg01579765 chr21:45077557 HSF2BP -0.33 -6.06 -0.32 3.73e-9 Mean corpuscular volume; CRC cis rs13118159 0.550 rs13123016 chr4:1340889 T/C cg19318889 chr4:1322082 MAEA 0.75 10.83 0.51 1.45e-23 Longevity; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg22041707 chr1:24127812 GALE 0.39 5.97 0.31 6.11e-9 Response to antipsychotic treatment; CRC cis rs11098499 0.954 rs3733519 chr4:120423448 A/G cg09307838 chr4:120376055 NA 0.74 11.29 0.53 3.43e-25 Corneal astigmatism; CRC cis rs9916302 0.706 rs1874226 chr17:37729031 C/T cg00129232 chr17:37814104 STARD3 0.59 7.17 0.37 5.11e-12 Glomerular filtration rate (creatinine); CRC trans rs3960554 1.000 rs3960554 chr7:75845597 G/T cg19862616 chr7:65841803 NCRNA00174 0.67 8.11 0.41 9.86e-15 Eotaxin levels; CRC cis rs1003719 0.715 rs2835667 chr21:38579914 G/A cg10648535 chr21:38446584 PIGP;TTC3 -0.45 -6.23 -0.32 1.41e-9 Eye color traits; CRC cis rs7399018 0.739 rs10747608 chr12:51616582 A/G cg12163867 chr12:51592794 POU6F1 -0.4 -6.26 -0.33 1.19e-9 Cisplatin-induced ototoxicity; CRC cis rs6540556 0.769 rs6540552 chr1:209927710 C/T cg23920097 chr1:209922102 NA 0.53 6.56 0.34 2.1e-10 Red blood cell count; CRC trans rs2797160 0.967 rs2747715 chr6:126007719 A/T cg05039488 chr6:79577232 IRAK1BP1 0.49 7.18 0.37 4.57e-12 Endometrial cancer; CRC cis rs72781680 1.000 rs12620594 chr2:24194490 G/A cg08917208 chr2:24149416 ATAD2B 0.91 9.28 0.46 2.29e-18 Lymphocyte counts; CRC cis rs17711722 0.503 rs453835 chr7:65511159 T/A cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.7 -10.69 -0.51 4.45e-23 Calcium levels; CRC trans rs3960554 0.932 rs4728597 chr7:75821062 C/T cg19862616 chr7:65841803 NCRNA00174 0.73 8.29 0.42 2.83e-15 Eotaxin levels; CRC cis rs9660992 0.789 rs1768584 chr1:205240145 A/G cg21643547 chr1:205240462 TMCC2 -0.46 -7.69 -0.39 1.72e-13 Mean corpuscular volume;Mean platelet volume; CRC cis rs9522267 0.535 rs9522299 chr13:112236013 C/A cg14352298 chr13:112236639 NA 0.29 6.74 0.35 7.32e-11 Hepatitis; CRC trans rs7824557 0.569 rs35418978 chr8:11186453 T/C cg06636001 chr8:8085503 FLJ10661 0.45 6.55 0.34 2.27e-10 Retinal vascular caliber; CRC cis rs875971 0.862 rs801195 chr7:66026115 A/G cg11764359 chr7:65958608 NA -0.58 -8.7 -0.43 1.62e-16 Aortic root size; CRC cis rs4713118 0.824 rs9366702 chr6:27734470 T/C cg21251018 chr6:28226885 NKAPL 0.42 5.91 0.31 8.46e-9 Parkinson's disease; CRC cis rs1153858 0.943 rs11070454 chr15:45680252 C/T cg10760299 chr15:45669010 GATM 0.5 7.9 0.4 4.16e-14 Homoarginine levels; CRC cis rs910316 0.967 rs11159121 chr14:75666029 A/T cg08847533 chr14:75593920 NEK9 -0.81 -14.29 -0.62 2.27e-36 Height; CRC cis rs10221833 0.636 rs355877 chr2:165632910 G/A cg03182029 chr2:165697222 COBLL1 0.49 5.68 0.3 3e-8 Response to statin therapy; CRC cis rs11785400 0.793 rs4457308 chr8:143733922 G/A cg24634471 chr8:143751801 JRK 0.52 7.16 0.37 5.17e-12 Schizophrenia; CRC cis rs6502050 0.761 rs12150321 chr17:80061558 T/C cg19223190 chr17:80058835 NA -0.45 -7.18 -0.37 4.78e-12 Life satisfaction; CRC cis rs311392 0.902 rs438437 chr8:55094187 G/C cg20636351 chr8:55087400 NA -0.32 -5.7 -0.3 2.69e-8 Pelvic organ prolapse (moderate/severe); CRC cis rs11123170 0.543 rs4849178 chr2:113982608 C/T cg21482265 chr2:113992762 PAX8;LOC440839;LOC654433 0.52 6.13 0.32 2.47e-9 Renal function-related traits (BUN); CRC cis rs7074356 0.704 rs1417220 chr10:82168154 G/A cg05935833 chr10:81318306 SFTPA2 -0.45 -6.53 -0.34 2.55e-10 Borderline personality disorder; CRC cis rs10097731 0.901 rs10464931 chr8:82042664 A/G cg25230327 chr8:82042993 NA 0.88 13.7 0.6 4.26e-34 Serum total protein level; CRC cis rs10504229 0.728 rs72650860 chr8:58153111 A/G cg08219700 chr8:58056026 NA 0.45 5.74 0.3 2.11e-8 Developmental language disorder (linguistic errors); CRC cis rs4664308 0.967 rs34248629 chr2:160902497 C/T cg03641300 chr2:160917029 PLA2R1 -0.74 -12.21 -0.56 1.54e-28 Idiopathic membranous nephropathy; CRC cis rs561341 1.000 rs4795667 chr17:30244443 T/C cg19193384 chr17:30244184 NA -0.59 -7.01 -0.36 1.38e-11 Hip circumference adjusted for BMI; CRC cis rs7309 0.870 rs2358016 chr2:162007430 C/G cg21211367 chr2:162094118 NA -0.38 -6.16 -0.32 2.12e-9 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Educational attainment; CRC cis rs12024301 0.557 rs10911398 chr1:183646886 G/T cg11505048 chr1:183622726 RGL1;APOBEC4 -0.71 -6.24 -0.33 1.33e-9 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs5769765 0.862 rs9616386 chr22:50313179 G/A cg08270630 chr22:50330655 NA -0.4 -5.61 -0.3 4.4e-8 Schizophrenia; CRC cis rs853679 0.517 rs9468297 chr6:28118874 G/T cg21251018 chr6:28226885 NKAPL 0.48 6.17 0.32 2.02e-9 Depression; CRC cis rs1865760 0.519 rs2275904 chr6:25768085 T/C cg17691542 chr6:26056736 HIST1H1C 0.69 8.69 0.43 1.7e-16 Height; CRC cis rs4727027 0.704 rs12704070 chr7:148902789 G/A cg23583168 chr7:148888333 NA -0.93 -17.93 -0.7 1.28e-50 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC cis rs9311676 0.656 rs12496906 chr3:58390490 A/C cg06643156 chr3:58380774 PXK 0.41 6.33 0.33 7.82e-10 Systemic lupus erythematosus; CRC cis rs1403694 0.669 rs10440056 chr3:186433822 C/T cg04611788 chr3:186434169 KNG1 -0.61 -9.13 -0.45 7.33e-18 Blood protein levels; CRC cis rs9916302 0.904 rs10852933 chr17:37698194 G/T cg07936489 chr17:37558343 FBXL20 -0.85 -13.29 -0.59 1.52e-32 Glomerular filtration rate (creatinine); CRC cis rs9487051 0.724 rs11966072 chr6:109634828 A/G cg01475377 chr6:109611718 NA -0.4 -6.0 -0.31 5.22e-9 Reticulocyte fraction of red cells; CRC cis rs7927771 0.524 rs11039415 chr11:47845814 A/G cg20307385 chr11:47447363 PSMC3 0.46 6.64 0.34 1.33e-10 Subjective well-being; CRC cis rs9309473 0.687 rs11693531 chr2:73608614 C/G cg20560298 chr2:73613845 ALMS1 -0.56 -7.39 -0.38 1.23e-12 Metabolite levels; CRC cis rs4308124 0.708 rs67816163 chr2:111963310 A/G cg04571233 chr2:111982156 NA -0.56 -8.23 -0.41 4.38e-15 Vitiligo; CRC cis rs826838 0.904 rs10876086 chr12:39188208 C/A cg26384229 chr12:38710491 ALG10B 0.69 9.33 0.46 1.61e-18 Heart rate; CRC cis rs5769765 0.862 rs9616392 chr22:50314705 G/A cg22709217 chr22:50311962 ALG12;CRELD2 -1.09 -18.09 -0.71 3.01e-51 Schizophrenia; CRC cis rs4974559 0.947 rs28418481 chr4:1330975 C/G cg02980000 chr4:1222292 CTBP1 0.51 6.49 0.34 3.24e-10 Systolic blood pressure; CRC cis rs1971762 0.527 rs1247956 chr12:53963814 G/T cg06632207 chr12:54070931 ATP5G2 -0.49 -8.29 -0.42 2.89e-15 Height; CRC cis rs2011503 1.000 rs77616520 chr19:19652776 G/A cg11584989 chr19:19387371 SF4 0.58 6.47 0.34 3.47e-10 Bipolar disorder; CRC cis rs637571 0.584 rs7107912 chr11:65603252 G/A cg04055107 chr11:65626734 MUS81;CFL1 -0.46 -6.54 -0.34 2.34e-10 Eosinophil percentage of white cells; CRC cis rs28386778 1.000 rs28386778 chr17:61964815 T/C cg00280220 chr17:61926910 NA 0.35 5.74 0.3 2.18e-8 Prudent dietary pattern; CRC cis rs2976388 0.578 rs34956412 chr8:143822028 C/T cg22687807 chr8:143858763 LYNX1 -0.44 -6.86 -0.35 3.4e-11 Urinary tract infection frequency; CRC cis rs853679 0.882 rs9366717 chr6:28191057 C/T cg15786705 chr6:28176104 NA 0.73 6.04 0.32 4.18e-9 Depression; CRC cis rs8099014 0.859 rs11152072 chr18:56098912 A/G cg12907477 chr18:56117327 MIR122 0.49 6.22 0.32 1.5e-9 Platelet count; CRC cis rs447 1.000 rs7793598 chr7:83759108 C/T cg22846510 chr7:83753280 SEMA3A -0.61 -7.79 -0.39 8.85e-14 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs10256972 0.552 rs2949195 chr7:1202705 G/A cg23978390 chr7:1156363 C7orf50 0.53 7.4 0.38 1.15e-12 Longevity;Endometriosis; CRC cis rs7246657 0.943 rs35540940 chr19:38008235 G/A cg23950597 chr19:37808831 NA -0.52 -5.9 -0.31 9.09e-9 Coronary artery calcification; CRC cis rs10946940 0.965 rs4713112 chr6:27516833 G/T cg03623178 chr6:28175578 NA -0.43 -5.72 -0.3 2.44e-8 Systemic lupus erythematosus; CRC cis rs28386778 0.863 rs3760254 chr17:61851751 T/G cg07362569 chr17:61921086 SMARCD2 0.38 5.84 0.31 1.25e-8 Prudent dietary pattern; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg25365794 chr17:8022404 ALOXE3 0.52 6.83 0.35 4.12e-11 Thyroid stimulating hormone; CRC cis rs4481887 0.893 rs4423045 chr1:248479495 T/C cg13385794 chr1:248469461 NA 0.41 7.17 0.37 4.84e-12 Common traits (Other); CRC cis rs7618501 0.521 rs868891 chr3:49949071 A/G cg24308560 chr3:49941425 MST1R -0.44 -6.64 -0.34 1.32e-10 Intelligence (multi-trait analysis); CRC cis rs3736485 0.932 rs2124879 chr15:51916833 T/C cg08986416 chr15:51914746 DMXL2 -0.45 -6.39 -0.33 5.54e-10 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC trans rs17685 0.712 rs1859792 chr7:75789264 T/C cg19862616 chr7:65841803 NCRNA00174 0.92 15.59 0.65 1.96e-41 Coffee consumption;Coffee consumption (cups per day); CRC cis rs7589728 1.000 rs7425670 chr2:88522028 C/T cg24977027 chr2:88469347 THNSL2 0.49 5.91 0.31 8.4e-9 Plasma clusterin levels; CRC cis rs11969893 0.649 rs12527901 chr6:101280435 G/A cg12253828 chr6:101329408 ASCC3 0.81 7.28 0.37 2.42e-12 Economic and political preferences (immigration/crime); CRC cis rs9297145 0.673 rs62473003 chr7:98725660 A/G cg05967295 chr7:98741636 SMURF1 1.1 15.62 0.65 1.61e-41 Crohn's disease;Inflammatory bowel disease;Ulcerative colitis; CRC cis rs12893668 0.603 rs61637848 chr14:104096031 C/T cg08213375 chr14:104286397 PPP1R13B 0.43 6.65 0.34 1.22e-10 Reticulocyte count; CRC trans rs2303319 0.504 rs62189046 chr2:162612371 C/G cg10498984 chr16:28874827 SH2B1 -0.73 -6.3 -0.33 9.75e-10 Cognitive function; CRC cis rs7605378 0.528 rs1704191 chr2:200816393 C/A cg23649088 chr2:200775458 C2orf69 0.7 11.28 0.53 3.48e-25 Osteoporosis; CRC cis rs3126085 0.935 rs7533529 chr1:152176871 T/C cg09127314 chr1:152161683 NA 0.52 6.58 0.34 1.87e-10 Atopic dermatitis; CRC cis rs911555 0.755 rs7147664 chr14:103963420 G/A cg12935359 chr14:103987150 CKB -0.54 -9.09 -0.45 9.57e-18 Intelligence (multi-trait analysis); CRC cis rs4332037 0.624 rs58169303 chr7:1883274 T/C cg13880726 chr7:1868755 MAD1L1 -0.44 -5.9 -0.31 9.07e-9 Bipolar disorder; CRC cis rs6952808 0.630 rs4719443 chr7:2161099 A/G cg21782813 chr7:2030301 MAD1L1 0.57 9.96 0.48 1.37e-20 Bipolar disorder and schizophrenia; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg24926775 chr1:151584391 SNX27 0.47 6.65 0.34 1.25e-10 Response to antipsychotic treatment; CRC cis rs2070488 0.745 rs9838792 chr3:38546726 G/A cg01465620 chr3:38496096 LOC100128640;ACVR2B -0.68 -11.18 -0.52 8.33e-25 Electrocardiographic conduction measures; CRC cis rs10504229 0.679 rs4738574 chr8:58033771 T/C cg22535103 chr8:58192502 C8orf71 -0.44 -5.85 -0.31 1.21e-8 Developmental language disorder (linguistic errors); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg08882271 chr5:61708404 IPO11 0.43 6.15 0.32 2.23e-9 Intelligence (multi-trait analysis); CRC cis rs4243830 0.850 rs4434862 chr1:6602241 C/A cg15205204 chr1:6545172 PLEKHG5 0.39 5.67 0.3 3.12e-8 Body mass index; CRC cis rs12541635 0.966 rs7819327 chr8:106986003 A/C cg10147462 chr8:107024639 NA 0.45 7.34 0.38 1.65e-12 Age of smoking initiation; CRC cis rs7208859 0.623 rs55938328 chr17:29117010 T/C cg01831904 chr17:28903510 LRRC37B2 -0.63 -6.49 -0.34 3.2e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs2880765 0.835 rs4536419 chr15:86039471 C/T cg17133734 chr15:86042851 AKAP13 0.45 7.19 0.37 4.29e-12 Coronary artery disease; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg06648271 chr10:126432949 FAM53B 0.44 6.57 0.34 2.02e-10 Intelligence (multi-trait analysis); CRC cis rs8060686 0.920 rs2292316 chr16:67861134 C/G cg07125278 chr16:67683757 RLTPR 0.63 7.37 0.38 1.4e-12 HDL cholesterol;Metabolic syndrome; CRC cis rs9311474 0.508 rs12629701 chr3:52619836 T/C cg08222913 chr3:52553049 STAB1 -0.34 -6.28 -0.33 1.1e-9 Electroencephalogram traits; CRC cis rs9818758 0.607 rs113186424 chr3:49272726 T/C cg07636037 chr3:49044803 WDR6 -0.7 -6.07 -0.32 3.56e-9 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; CRC cis rs9309711 0.961 rs11692184 chr2:3480710 C/T cg10845886 chr2:3471009 TTC15 -0.68 -10.85 -0.51 1.24e-23 Neurofibrillary tangles; CRC trans rs1814175 0.935 rs10839329 chr11:49694206 G/A cg15704280 chr7:45808275 SEPT13 -0.98 -18.48 -0.71 8.77e-53 Height; CRC cis rs9287719 0.649 rs10166765 chr2:10725673 T/C cg00105475 chr2:10696890 NA 0.44 7.0 0.36 1.43e-11 Prostate cancer; CRC cis rs6860806 0.507 rs2631369 chr5:131705266 G/C cg09877947 chr5:131593287 PDLIM4 -0.45 -7.47 -0.38 7.26e-13 Breast cancer; CRC cis rs8177253 0.828 rs8177259 chr3:133480388 T/C cg11941060 chr3:133502564 NA -0.59 -10.21 -0.49 1.99e-21 Iron status biomarkers; CRC cis rs6502050 0.835 rs8079389 chr17:80158656 T/G cg19223190 chr17:80058835 NA 0.41 6.6 0.34 1.61e-10 Life satisfaction; CRC cis rs7937682 0.889 rs10789844 chr11:111579109 A/T cg09085632 chr11:111637200 PPP2R1B -1.02 -20.21 -0.74 1.24e-59 Primary sclerosing cholangitis; CRC cis rs34779708 0.931 rs4934710 chr10:35350416 T/C cg03585969 chr10:35415529 CREM 0.65 8.64 0.43 2.46e-16 Inflammatory bowel disease;Crohn's disease; CRC cis rs6952808 0.792 rs4721184 chr7:1950784 T/C cg20295408 chr7:1910781 MAD1L1 -0.43 -5.92 -0.31 8.11e-9 Bipolar disorder and schizophrenia; CRC cis rs6963495 0.745 rs73192152 chr7:105212258 A/C cg02135003 chr7:105160482 PUS7 -0.95 -12.58 -0.57 6.68e-30 Bipolar disorder (body mass index interaction); CRC cis rs875971 1.000 rs4717292 chr7:65895598 G/A cg18876405 chr7:65276391 NA 0.52 8.85 0.44 5.32e-17 Aortic root size; CRC cis rs12477438 0.798 rs1993230 chr2:99686079 T/C cg26064155 chr2:99771622 LIPT1;TSGA10 -0.79 -11.23 -0.53 5.57e-25 Chronic sinus infection; CRC cis rs2404602 0.684 rs4886819 chr15:76901698 C/T cg23625390 chr15:77176239 SCAPER -0.85 -13.5 -0.6 2.35e-33 Blood metabolite levels; CRC cis rs7512552 0.839 rs1694369 chr1:150351101 A/G cg15654264 chr1:150340011 RPRD2 0.59 8.34 0.42 2.06e-15 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); CRC cis rs3099143 0.908 rs6495222 chr15:77180015 A/C cg21673338 chr15:77095150 SCAPER 0.72 7.66 0.39 2.14e-13 Recalcitrant atopic dermatitis; CRC cis rs6500395 1.000 rs8059905 chr16:48629934 C/T cg04672837 chr16:48644449 N4BP1 0.44 6.65 0.34 1.19e-10 Response to tocilizumab in rheumatoid arthritis; CRC trans rs28735056 0.904 rs11520415 chr18:77620620 C/T cg03973167 chr4:185394988 IRF2 -0.46 -6.53 -0.34 2.52e-10 Schizophrenia; CRC cis rs1448094 0.511 rs59668915 chr12:86197170 C/T cg25456477 chr12:86230367 RASSF9 0.33 5.85 0.31 1.18e-8 Major depressive disorder; CRC cis rs6763159 1.000 rs6763159 chr3:59649521 T/C cg07069742 chr3:59644285 NA -0.33 -6.55 -0.34 2.27e-10 Conotruncal heart defects; CRC cis rs11190604 1.000 rs10883501 chr10:102238326 A/G cg16342193 chr10:102329863 NA -0.36 -5.86 -0.31 1.14e-8 Palmitoleic acid (16:1n-7) levels; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg07173973 chr19:45596087 NA 0.45 6.15 0.32 2.28e-9 Response to antipsychotic treatment; CRC cis rs8105895 0.867 rs62111037 chr19:22286563 C/T cg02912127 chr19:22235281 ZNF257 -0.41 -5.7 -0.3 2.62e-8 Body mass index (change over time); CRC cis rs9611565 0.659 rs56364401 chr22:41951243 T/G cg17554472 chr22:41940697 POLR3H -0.56 -6.01 -0.31 4.84e-9 Vitiligo; CRC cis rs1401999 1.000 rs6802849 chr3:183698943 A/C cg05044414 chr3:183734942 ABCC5 0.48 8.34 0.42 2.1e-15 Anterior chamber depth; CRC cis rs11971779 0.715 rs10085527 chr7:139064360 G/A cg23387468 chr7:139079360 LUC7L2 0.4 6.96 0.36 1.9e-11 Diisocyanate-induced asthma; CRC cis rs7572644 0.639 rs74429612 chr2:27993843 C/T cg27432699 chr2:27873401 GPN1 0.47 5.73 0.3 2.27e-8 Response to carboplatin and paclitaxel in ovarian cancer (Caspase 3/7 EC50); CRC cis rs1401999 1.000 rs2313217 chr3:183635997 A/G cg20387954 chr3:183756860 HTR3D 0.44 7.41 0.38 1.06e-12 Anterior chamber depth; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg26744078 chr19:57752172 ZNF805 0.44 5.96 0.31 6.5e-9 Anxiety disorder; CRC cis rs1552244 0.572 rs66514627 chr3:10166632 A/C cg10729496 chr3:10149963 C3orf24 0.48 5.61 0.3 4.19e-8 Alzheimer's disease; CRC cis rs10540 1.000 rs61876335 chr11:488878 T/C cg19913688 chr11:428466 ANO9 -0.59 -6.26 -0.33 1.23e-9 Body mass index; CRC trans rs2303319 0.504 rs62189048 chr2:162613494 G/C cg23247704 chr1:116518985 SLC22A15 -0.72 -6.14 -0.32 2.42e-9 Cognitive function; CRC cis rs1062746 0.683 rs891094 chr16:87378001 C/G cg02258303 chr16:87377426 FBXO31 0.65 10.87 0.51 1.03e-23 Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 2 peripheral neuropathy); CRC cis rs9372498 0.536 rs17080302 chr6:118854037 A/G cg10217327 chr6:118973057 C6orf204 0.51 5.78 0.3 1.73e-8 Diastolic blood pressure; CRC cis rs7666738 0.753 rs35146453 chr4:98902278 A/G cg17366294 chr4:99064904 C4orf37 0.41 6.79 0.35 5.15e-11 Colonoscopy-negative controls vs population controls; CRC cis rs6504950 0.705 rs9899602 chr17:52986908 C/T cg26251398 chr17:52985966 TOM1L1 -0.42 -6.2 -0.32 1.69e-9 Breast cancer; CRC cis rs7937682 0.883 rs542831 chr11:111471392 T/A cg09085632 chr11:111637200 PPP2R1B -0.97 -18.67 -0.72 1.46e-53 Primary sclerosing cholangitis; CRC cis rs2239547 0.657 rs7638524 chr3:52874861 G/A cg10802521 chr3:52805072 NEK4 -0.46 -6.16 -0.32 2.17e-9 Schizophrenia; CRC cis rs9322193 0.886 rs9718079 chr6:149967083 T/C cg05861140 chr6:150128134 PCMT1 -0.37 -5.93 -0.31 7.87e-9 Lung cancer; CRC cis rs9682041 0.932 rs6782252 chr3:170133639 C/T cg11886554 chr3:170076028 SKIL 1.06 11.38 0.53 1.62e-25 Glomerular filtration rate in non diabetics (creatinine);Glomerular filtration rate (creatinine); CRC cis rs250677 0.687 rs40522 chr5:148442295 G/A cg23229984 chr5:148520753 ABLIM3 0.49 6.8 0.35 4.85e-11 Breast cancer; CRC cis rs4713118 0.539 rs200951 chr6:27835930 A/G cg12172441 chr6:28176163 NA 0.5 6.74 0.35 7.17e-11 Parkinson's disease; CRC cis rs1799949 0.931 rs9912203 chr17:41445145 A/G cg25072359 chr17:41440525 NA -0.5 -7.98 -0.4 2.39e-14 Menopause (age at onset); CRC cis rs17253792 0.598 rs12880362 chr14:56017929 G/C cg01858014 chr14:56050164 KTN1 -0.86 -6.64 -0.34 1.27e-10 Putamen volume; CRC cis rs11690935 1.000 rs2138348 chr2:172558172 A/C cg13550731 chr2:172543902 DYNC1I2 1.07 18.04 0.71 4.67e-51 Schizophrenia; CRC cis rs4713118 0.662 rs149948 chr6:27974817 C/G cg02631126 chr6:28058918 ZSCAN12L1 0.24 5.71 0.3 2.57e-8 Parkinson's disease; CRC cis rs4803480 0.873 rs1476770 chr19:42084385 C/G cg08478046 chr19:42093086 CEACAM21 -0.33 -5.88 -0.31 1.01e-8 Schizophrenia; CRC cis rs9914988 1.000 rs9914988 chr17:27183104 G/A cg16670446 chr17:27188758 MIR451;MIR144 -0.61 -10.36 -0.5 5.96e-22 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs1863824 0.625 rs10887599 chr10:88168780 G/A cg07322936 chr10:88137208 NA -0.64 -8.66 -0.43 2.11e-16 Schizophrenia; CRC cis rs832540 0.931 rs331499 chr5:56210923 C/T cg18230493 chr5:56204884 C5orf35 -0.39 -5.61 -0.3 4.21e-8 Coronary artery disease; CRC cis rs2223471 0.719 rs17608920 chr6:50773860 G/A cg03432817 chr6:50765336 NA 0.39 6.26 0.33 1.19e-9 Subcutaneous adipose tissue; CRC trans rs11764590 0.694 rs3996323 chr7:2079428 G/T cg11693508 chr17:37793320 STARD3 0.47 6.44 0.33 4.22e-10 Neuroticism; CRC cis rs9467711 0.606 rs9358936 chr6:26370657 A/G cg14345882 chr6:26364793 BTN3A2 0.65 5.74 0.3 2.17e-8 Autism spectrum disorder or schizophrenia; CRC trans rs41997 0.785 rs2110215 chr7:118071216 C/T cg02756545 chr1:94884060 ABCD3 -0.62 -6.16 -0.32 2.13e-9 Response to platinum-based chemotherapy in non-small-cell lung cancer; CRC cis rs4969178 0.965 rs938351 chr17:76399404 C/T cg05887092 chr17:76393375 PGS1 0.56 10.04 0.48 7.37e-21 HDL cholesterol levels; CRC cis rs651907 0.535 rs34743741 chr3:101532448 C/T cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.58 7.69 0.39 1.73e-13 Colorectal cancer; CRC trans rs1945213 0.694 rs11227113 chr11:55828024 C/T cg03929089 chr4:120376271 NA 0.56 6.42 0.33 4.68e-10 Acute lymphoblastic leukemia (childhood); CRC cis rs6500602 1.000 rs7204827 chr16:4467533 C/T cg08645402 chr16:4508243 NA 0.53 8.87 0.44 4.83e-17 Schizophrenia; CRC cis rs3087591 0.960 rs2285812 chr17:29533871 A/G cg24425628 chr17:29625626 OMG;NF1 0.86 16.76 0.68 5.38e-46 Hip circumference; CRC cis rs12024301 0.557 rs60156786 chr1:183596905 A/G cg11505048 chr1:183622726 RGL1;APOBEC4 0.76 6.93 0.36 2.16e-11 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs216303 1.000 rs216303 chr12:6159045 C/T cg19878637 chr12:6148451 VWF -0.55 -6.08 -0.32 3.35e-9 Low vWF levels; CRC cis rs554111 0.963 rs710312 chr1:21042462 A/G cg00373020 chr1:21041521 KIF17 0.4 6.17 0.32 2.04e-9 Facial morphology (factor 17, height of vermillion upper lip); CRC cis rs7666738 0.830 rs1559859 chr4:99024325 C/T cg17366294 chr4:99064904 C4orf37 0.43 7.3 0.37 2.14e-12 Colonoscopy-negative controls vs population controls; CRC cis rs6120849 0.754 rs6088682 chr20:33615702 A/C cg08999081 chr20:33150536 PIGU 0.45 5.79 0.3 1.65e-8 Protein C levels; CRC cis rs6500602 0.702 rs1051308 chr16:4560301 A/G cg14951292 chr16:4525986 HMOX2;NMRAL1 -0.56 -8.54 -0.43 5.17e-16 Schizophrenia; CRC cis rs17767392 0.958 rs34169215 chr14:72011148 C/A cg13720639 chr14:72061746 SIPA1L1 -0.57 -7.3 -0.37 2.25e-12 Mitral valve prolapse; CRC cis rs2836974 0.568 rs414850 chr21:40543337 A/C cg17971929 chr21:40555470 PSMG1 0.74 11.79 0.55 5.27e-27 Cognitive function; CRC cis rs599083 0.530 rs667126 chr11:68177728 C/T cg16797656 chr11:68205561 LRP5 -0.38 -6.13 -0.32 2.5e-9 Bone mineral density (spine); CRC cis rs5750830 0.649 rs5750814 chr22:39797987 T/C cg11247378 chr22:39784982 NA -0.49 -9.82 -0.48 4.02e-20 Intelligence (multi-trait analysis); CRC cis rs877282 0.898 rs2004478 chr10:770709 C/A cg17470449 chr10:769945 NA 0.61 8.72 0.43 1.36e-16 Uric acid levels; CRC cis rs1046896 0.731 rs8067667 chr17:80785875 A/G cg08200770 chr17:80723486 TBCD -0.5 -7.67 -0.39 1.95e-13 Glycated hemoglobin levels; CRC cis rs9359856 0.564 rs72915946 chr6:90447924 C/T cg13799429 chr6:90582589 CASP8AP2 -0.75 -7.58 -0.39 3.44e-13 Bipolar disorder; CRC cis rs6582630 0.519 rs12582285 chr12:38298753 C/T cg13010199 chr12:38710504 ALG10B 0.47 6.29 0.33 1.01e-9 Drug-induced liver injury (flucloxacillin); CRC cis rs7918232 0.882 rs788211 chr10:27479070 C/T cg14442939 chr10:27389572 ANKRD26 -0.88 -9.47 -0.46 5.71e-19 Breast cancer; CRC cis rs3743266 0.613 rs1869485 chr15:60746605 G/A cg21667061 chr15:60772094 NARG2 -0.28 -5.74 -0.3 2.11e-8 Menarche (age at onset); CRC cis rs59104589 0.617 rs3755400 chr2:242379795 A/C cg19488206 chr2:242435732 STK25 -0.51 -7.25 -0.37 2.97e-12 Fibrinogen levels; CRC trans rs916888 0.773 rs1378358 chr17:44787312 C/T cg01341218 chr17:43662625 NA 1.01 10.66 0.51 5.36e-23 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs7618915 0.547 rs11709448 chr3:52647449 T/C cg10802521 chr3:52805072 NEK4 -0.57 -8.71 -0.43 1.52e-16 Bipolar disorder; CRC cis rs1003719 0.725 rs2187101 chr21:38452379 T/C cg10648535 chr21:38446584 PIGP;TTC3 0.53 7.5 0.38 6.05e-13 Eye color traits; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg08292968 chr12:111020671 PPTC7 0.41 6.62 0.34 1.44e-10 Liver disease severity in Alagille syndrome; CRC cis rs34891900 0.507 rs5992088 chr22:18135912 C/T cg19898043 chr22:18121309 BCL2L13 -0.5 -7.4 -0.38 1.13e-12 Sum neutrophil eosinophil counts; CRC cis rs68170813 0.559 rs17428071 chr7:106878200 C/G cg02696742 chr7:106810147 HBP1 -0.59 -6.35 -0.33 7.14e-10 Coronary artery disease; CRC cis rs34172651 0.517 rs36113933 chr16:24838862 A/G cg06505273 chr16:24850292 NA 0.54 7.04 0.36 1.12e-11 Intelligence (multi-trait analysis); CRC cis rs13108904 0.967 rs12642396 chr4:1293055 C/A cg21620606 chr4:1342894 KIAA1530 0.34 5.65 0.3 3.53e-8 Obesity-related traits; CRC cis rs7524258 0.900 rs6670323 chr1:7301947 C/A cg07173049 chr1:7289937 CAMTA1 0.59 9.61 0.47 1.94e-19 Tourette's syndrome or obsessive-compulsive disorder; CRC trans rs1814175 0.645 rs847632 chr11:49926097 C/T cg21153622 chr11:89784906 NA -0.39 -6.08 -0.32 3.33e-9 Height; CRC cis rs644799 1.000 rs527899 chr11:95529242 T/G cg25622487 chr11:95524042 FAM76B;CEP57 0.76 11.87 0.55 2.62e-27 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs936229 0.813 rs8033381 chr15:75080685 G/A cg10253484 chr15:75165896 SCAMP2 -0.39 -5.64 -0.3 3.74e-8 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); CRC cis rs10986311 0.832 rs9695388 chr9:127141727 C/A cg14243010 chr9:127117328 LOC100129034;PSMB7 -0.39 -5.72 -0.3 2.38e-8 Vitiligo; CRC cis rs3820068 0.603 rs927207 chr1:15990552 A/G cg13390004 chr1:15929781 NA 0.53 7.23 0.37 3.46e-12 Systolic blood pressure; CRC cis rs6582630 0.519 rs1607868 chr12:38385512 G/T cg13010199 chr12:38710504 ALG10B 0.47 6.37 0.33 6.41e-10 Drug-induced liver injury (flucloxacillin); CRC cis rs3736485 0.934 rs4143721 chr15:51866781 A/G cg08986416 chr15:51914746 DMXL2 -0.46 -6.64 -0.34 1.29e-10 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs4819052 0.851 rs4819043 chr21:46660078 G/A cg19498844 chr21:46707878 POFUT2;LOC642852 0.75 10.82 0.51 1.49e-23 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs711830 1.000 rs1549334 chr2:177039197 G/A cg13092806 chr2:177043255 NA 0.72 9.04 0.45 1.39e-17 Serous invasive ovarian cancer;Epithelial ovarian cancer;Invasive epithelial ovarian cancer;Mucinous ovarian carcinoma;Low-grade serous and serous borderline ovarian cancer;Serous borderline ovarian cancer;High-grade serous ovarian cancer; CRC cis rs72781680 0.898 rs6545127 chr2:24060670 C/T cg08917208 chr2:24149416 ATAD2B 0.88 8.93 0.44 3.07e-17 Lymphocyte counts; CRC cis rs5167 0.504 rs4803781 chr19:45459671 C/T cg13119609 chr19:45449297 APOC2 0.31 5.93 0.31 7.77e-9 Blood protein levels; CRC cis rs2404602 0.684 rs1011083 chr15:77007527 C/T cg03037974 chr15:76606532 NA -0.52 -7.84 -0.4 6.23e-14 Blood metabolite levels; CRC cis rs4481887 0.927 rs4244173 chr1:248466899 G/C cg13385794 chr1:248469461 NA 0.39 6.95 0.36 2.03e-11 Common traits (Other); CRC cis rs6502050 0.835 rs6502068 chr17:80112223 C/T cg13198984 chr17:80129470 CCDC57 0.46 8.12 0.41 9.42e-15 Life satisfaction; CRC trans rs12699921 0.632 rs2691597 chr7:17870340 C/T cg15753394 chr6:17282781 RBM24 -0.36 -6.11 -0.32 2.81e-9 Fibrinogen levels; CRC trans rs10411161 0.702 rs79180893 chr19:52395615 A/G cg22319618 chr22:45562946 NUP50 -0.58 -6.01 -0.31 4.92e-9 Breast cancer; CRC cis rs7666738 0.887 rs34509663 chr4:98982531 C/T cg03676636 chr4:99064102 C4orf37 0.24 6.67 0.35 1.08e-10 Colonoscopy-negative controls vs population controls; CRC cis rs9911578 0.967 rs7214892 chr17:57065401 G/A cg12560992 chr17:57184187 TRIM37 0.92 17.13 0.69 1.78e-47 Intelligence (multi-trait analysis); CRC cis rs1568889 0.712 rs10835306 chr11:28302410 A/G cg06544937 chr11:28130018 METT5D1;KIF18A 0.91 15.36 0.65 1.59e-40 Bipolar disorder; CRC cis rs10504229 0.683 rs2318143 chr8:58114660 C/T cg04204079 chr8:58130323 NA -0.45 -5.84 -0.31 1.27e-8 Developmental language disorder (linguistic errors); CRC cis rs1018836 0.628 rs35816262 chr8:91511017 C/G cg16814680 chr8:91681699 NA -0.68 -10.06 -0.49 6.04e-21 Ejection fraction in Tripanosoma cruzi seropositivity; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg25360663 chr11:66035791 RAB1B 0.44 6.23 0.32 1.42e-9 Response to antipsychotic treatment; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg13309018 chr9:130965761 CIZ1;DNM1 0.49 6.49 0.34 3.17e-10 Thyroid stimulating hormone; CRC cis rs2576037 0.526 rs626217 chr18:44429182 T/G cg23996704 chr18:44553084 KATNAL2 -0.34 -7.0 -0.36 1.4e-11 Personality dimensions; CRC cis rs727563 0.555 rs5751136 chr22:42075581 T/A cg03806693 chr22:41940476 POLR3H 0.9 11.64 0.54 1.83e-26 Crohn's disease;Inflammatory bowel disease; CRC cis rs9491140 0.539 rs11154221 chr6:124675246 C/T cg05308643 chr6:124982296 NKAIN2 0.45 6.28 0.33 1.09e-9 Neuroticism; CRC cis rs11190604 1.000 rs12355721 chr10:102244911 C/T cg07080220 chr10:102295463 HIF1AN 0.49 5.91 0.31 8.45e-9 Palmitoleic acid (16:1n-7) levels; CRC cis rs881375 1.000 rs10760118 chr9:123641616 C/T cg09586646 chr9:123605570 PSMD5;LOC253039 0.49 6.72 0.35 7.82e-11 Rheumatoid arthritis; CRC trans rs2821260 0.902 rs12131816 chr1:72529866 A/G cg07921184 chr16:71880281 ATXN1L -0.48 -6.05 -0.32 3.97e-9 Intelligence (multi-trait analysis); CRC cis rs593982 1.000 rs576663 chr11:65498942 G/T cg08755490 chr11:65554678 OVOL1 1.2 18.64 0.72 2.04e-53 Atopic dermatitis; CRC cis rs2836950 0.502 rs2150411 chr21:40574552 G/T cg06238570 chr21:40685208 BRWD1 -0.63 -9.22 -0.45 3.56e-18 Menarche (age at onset); CRC cis rs6724607 1.000 rs13006708 chr2:191471428 G/A cg27211696 chr2:191398769 TMEM194B -0.42 -6.25 -0.33 1.26e-9 Pulse pressure; CRC cis rs4237845 0.844 rs4630335 chr12:58302258 A/G cg00677455 chr12:58241039 CTDSP2 0.58 8.23 0.41 4.55e-15 Intelligence (multi-trait analysis); CRC cis rs6540559 1.000 rs6696825 chr1:209982372 A/G cg23283495 chr1:209979779 IRF6 0.4 6.64 0.34 1.27e-10 Cleft lip with or without cleft palate; CRC cis rs17401966 0.838 rs912963 chr1:10348042 C/T cg19773385 chr1:10388646 KIF1B -0.65 -10.75 -0.51 2.65e-23 Hepatocellular carcinoma; CRC cis rs2404602 0.716 rs12917430 chr15:76674360 T/C cg03037974 chr15:76606532 NA 0.71 12.58 0.57 6.58e-30 Blood metabolite levels; CRC trans rs10838798 0.523 rs4752917 chr11:48241639 A/G cg21153622 chr11:89784906 NA -0.47 -7.87 -0.4 5.04e-14 Height; CRC cis rs12908161 1.000 rs60957376 chr15:85280792 T/G cg11189052 chr15:85197271 WDR73 0.58 8.41 0.42 1.23e-15 Schizophrenia; CRC trans rs1455244 0.700 rs7229302 chr18:11508904 G/T cg06788803 chr1:45805948 MUTYH;TOE1 0.4 6.17 0.32 1.95e-9 Schizophrenia; CRC cis rs10080237 0.564 rs2490232 chr6:80814802 C/T cg08355045 chr6:80787529 NA -0.41 -6.93 -0.36 2.29e-11 Waist circumference adjusted for body mass index;Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction);Waist circumference adjusted for BMI in active individuals; CRC cis rs539096 0.692 rs6669157 chr1:44216876 T/C cg12908607 chr1:44402522 ARTN -0.35 -6.04 -0.32 4.1e-9 Intelligence (multi-trait analysis); CRC cis rs10504229 1.000 rs112284078 chr8:58191640 A/G cg22535103 chr8:58192502 C8orf71 -0.81 -11.71 -0.54 1.03e-26 Developmental language disorder (linguistic errors); CRC cis rs2370759 1.000 rs75984055 chr10:32591276 T/C cg01819863 chr10:32635814 EPC1 1.09 12.84 0.58 7.37e-31 Sexual dysfunction (female); CRC cis rs3749237 0.615 rs6792911 chr3:49429856 C/T cg02487422 chr3:49467188 NICN1 0.43 7.06 0.36 9.77e-12 Resting heart rate; CRC cis rs17401966 0.540 rs4846199 chr1:10283961 A/G cg19773385 chr1:10388646 KIF1B -0.49 -7.76 -0.39 1.06e-13 Hepatocellular carcinoma; CRC cis rs736408 0.562 rs2072390 chr3:52780509 A/T cg05573699 chr3:52720067 GNL3;PBRM1 -0.44 -6.38 -0.33 6.13e-10 Bipolar disorder; CRC trans rs7267979 0.966 rs4813557 chr20:25292545 C/T cg17903999 chr18:56338584 MALT1 0.42 6.91 0.36 2.58e-11 Liver enzyme levels (alkaline phosphatase); CRC cis rs9463078 0.547 rs4711798 chr6:44750777 A/G cg25276700 chr6:44698697 NA -0.31 -7.78 -0.39 9.37e-14 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; CRC cis rs7927592 0.956 rs12365160 chr11:68250419 A/G cg01657329 chr11:68192670 LRP5 -0.46 -6.67 -0.35 1.09e-10 Total body bone mineral density; CRC cis rs2011503 0.941 rs6511027 chr19:19391851 C/T cg11584989 chr19:19387371 SF4 0.5 6.19 0.32 1.8e-9 Bipolar disorder; CRC cis rs644799 0.625 rs1255177 chr11:95471495 A/G cg25622487 chr11:95524042 FAM76B;CEP57 0.44 6.33 0.33 8.22e-10 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs2303759 0.709 rs10411679 chr19:49826480 A/T cg22133161 chr19:49891603 CCDC155 0.51 6.65 0.34 1.21e-10 Multiple sclerosis; CRC cis rs6565180 0.888 rs8060853 chr16:30403858 A/G cg17640201 chr16:30407289 ZNF48 0.8 12.68 0.57 2.84e-30 Tonsillectomy; CRC cis rs939584 1.000 rs10865550 chr2:641718 T/G cg03610516 chr2:642275 NA 0.41 5.77 0.3 1.83e-8 Body mass index; CRC cis rs9322193 0.607 rs4869755 chr6:150207483 G/A cg07701084 chr6:150067640 NUP43 0.47 5.78 0.3 1.73e-8 Lung cancer; CRC cis rs10911232 0.507 rs10737239 chr1:183030170 A/C ch.1.3577855R chr1:183094577 LAMC1 0.83 14.36 0.62 1.26e-36 Hypertriglyceridemia; CRC cis rs7811142 0.775 rs1059129 chr7:99926522 A/G cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.61 8.21 0.41 4.99e-15 Platelet count; CRC cis rs1691799 0.899 rs1060724 chr12:66740444 T/C cg16791601 chr12:66731901 HELB -0.67 -11.29 -0.53 3.27e-25 White blood cell count (basophil); CRC cis rs9916302 0.904 rs11078898 chr17:37536480 A/G cg15445000 chr17:37608096 MED1 -0.44 -9.87 -0.48 2.68e-20 Glomerular filtration rate (creatinine); CRC cis rs10504229 1.000 rs67913746 chr8:58177825 A/G cg01721255 chr8:58191610 C8orf71 0.49 6.17 0.32 2e-9 Developmental language disorder (linguistic errors); CRC trans rs7647973 0.710 rs9869120 chr3:49624065 T/C cg21659725 chr3:3221576 CRBN -0.69 -7.14 -0.37 6.11e-12 Menarche (age at onset); CRC cis rs35146811 0.586 rs10267231 chr7:99595480 T/C cg13334819 chr7:99746414 C7orf59 -0.46 -6.31 -0.33 9.18e-10 Coronary artery disease; CRC cis rs524281 0.731 rs11227439 chr11:66025679 G/A cg16950941 chr11:66035639 RAB1B -0.72 -8.08 -0.41 1.24e-14 Electroencephalogram traits; CRC cis rs9303401 0.614 rs8081058 chr17:57160513 G/C cg02118635 chr17:56770003 RAD51C;TEX14 0.68 8.42 0.42 1.15e-15 Cognitive test performance; CRC cis rs3858526 0.839 rs10466484 chr11:5943696 A/G cg02574844 chr11:5959923 NA -0.41 -5.84 -0.31 1.24e-8 DNA methylation (variation); CRC cis rs17666538 0.710 rs7834337 chr8:655828 A/G cg27048067 chr8:674560 ERICH1 0.5 5.92 0.31 8.01e-9 IgG glycosylation; CRC cis rs929354 0.772 rs3802125 chr7:156970563 A/C cg17757837 chr7:157058334 UBE3C 0.71 11.72 0.54 9.78e-27 Body mass index; CRC cis rs8180040 1.000 rs295428 chr3:47359262 G/T cg10298567 chr3:47292165 KIF9 -0.4 -6.72 -0.35 8.24e-11 Colorectal cancer; CRC cis rs10781543 0.763 rs10781539 chr9:139320965 G/A cg13856295 chr9:139396418 NOTCH1 -0.38 -5.64 -0.3 3.57e-8 Monocyte percentage of white cells; CRC cis rs7267979 0.727 rs2474765 chr20:25245950 G/T cg24626310 chr20:25276739 ABHD12;PYGB 0.35 5.8 0.3 1.56e-8 Liver enzyme levels (alkaline phosphatase); CRC cis rs652260 0.967 rs569175 chr19:7901160 T/G cg26014689 chr19:7917955 EVI5L -0.54 -8.83 -0.44 6.37e-17 Menarche (age at onset); CRC cis rs72627123 0.867 rs73301475 chr14:74462868 C/T cg12022184 chr14:74485813 ENTPD5;C14orf45 0.72 6.02 0.31 4.74e-9 Morning vs. evening chronotype; CRC cis rs3741404 0.594 rs11231704 chr11:63898182 C/T cg06219103 chr11:63990595 FERMT3 0.37 5.7 0.3 2.71e-8 Platelet count; CRC cis rs12540874 0.698 rs10899736 chr7:50546925 C/T cg18232548 chr7:50535776 DDC -0.52 -7.81 -0.4 7.53e-14 Systemic sclerosis; CRC cis rs3087591 0.922 rs757383 chr17:29596045 C/G cg24425628 chr17:29625626 OMG;NF1 0.87 16.75 0.68 5.73e-46 Hip circumference; CRC cis rs72615157 0.613 rs56089143 chr7:99819844 G/A cg13153964 chr7:100026424 MEPCE;ZCWPW1 0.79 9.82 0.48 4.06e-20 Lung function (FEV1/FVC); CRC cis rs2227564 0.620 rs3812637 chr10:75568846 C/T cg16540259 chr10:75572220 NDST2 0.51 7.96 0.4 2.82e-14 Crohn's disease;Inflammatory bowel disease; CRC cis rs798554 0.671 rs1182195 chr7:2868730 A/G cg19717773 chr7:2847554 GNA12 -0.44 -7.24 -0.37 3.16e-12 Height; CRC cis rs9322193 0.962 rs2151912 chr6:150152908 A/G cg05861140 chr6:150128134 PCMT1 -0.45 -7.19 -0.37 4.52e-12 Lung cancer; CRC cis rs4862750 0.914 rs11943333 chr4:187872455 A/G cg10295955 chr4:187884368 NA -0.97 -20.93 -0.76 1.86e-62 Lobe attachment (rater-scored or self-reported); CRC cis rs35306767 0.903 rs11253494 chr10:937047 C/T cg20503657 chr10:835505 NA 0.93 11.27 0.53 3.8e-25 Eosinophil percentage of granulocytes; CRC cis rs208520 0.565 rs1385222 chr6:66753013 C/T cg07460842 chr6:66804631 NA 1.1 20.48 0.75 1.1e-60 Exhaled nitric oxide output; CRC cis rs11252926 0.673 rs816620 chr10:645916 A/G cg03684893 chr10:554711 DIP2C 0.32 5.6 0.3 4.42e-8 Psychosis in Alzheimer's disease; CRC trans rs1814175 0.645 rs11040535 chr11:49808669 C/T cg11707556 chr5:10655725 ANKRD33B -0.49 -9.16 -0.45 5.49e-18 Height; CRC cis rs765787 0.505 rs4439707 chr15:45524216 G/A cg24006582 chr15:45444508 DUOX1 0.56 8.15 0.41 7.95e-15 Uric acid levels; CRC cis rs9611565 0.659 rs9611603 chr22:41912750 A/G cg06634786 chr22:41940651 POLR3H -0.66 -7.74 -0.39 1.27e-13 Vitiligo; CRC cis rs6496667 0.779 rs8041764 chr15:90968264 G/A cg04176472 chr15:90893244 GABARAPL3 0.61 8.51 0.42 6.23e-16 Rheumatoid arthritis; CRC cis rs6502050 0.835 rs28640920 chr17:80105151 A/T cg22110888 chr17:80059540 CCDC57 0.4 6.44 0.33 4.17e-10 Life satisfaction; CRC trans rs7615952 0.546 rs2976733 chr3:125414138 T/C cg08546805 chr12:8549446 NA -0.4 -6.12 -0.32 2.67e-9 Blood pressure (smoking interaction); CRC cis rs2882667 0.690 rs825747 chr5:138136585 C/T cg09476006 chr5:138032270 NA -0.54 -8.88 -0.44 4.48e-17 Age-related hearing impairment (SNP x SNP interaction); CRC trans rs561341 0.714 rs111760509 chr17:30304320 A/G cg20587970 chr11:113659929 NA -1.43 -20.28 -0.75 6.84e-60 Hip circumference adjusted for BMI; CRC cis rs4555082 0.834 rs2816652 chr14:105712493 C/T cg18132624 chr14:105716052 BTBD6;BRF1 -0.52 -8.67 -0.43 2.04e-16 Mean platelet volume;Platelet distribution width; CRC cis rs6748734 0.901 rs6720357 chr2:241830296 A/C cg04034577 chr2:241836375 C2orf54 -0.42 -8.82 -0.44 6.9e-17 Urinary metabolites; CRC cis rs2180341 1.000 rs6569479 chr6:127606588 A/G cg27446573 chr6:127587934 RNF146 1.0 14.8 0.63 2.32e-38 Breast cancer; CRC cis rs4713118 0.662 rs149901 chr6:27965503 C/T cg02683197 chr6:28174875 NA 0.65 9.03 0.45 1.48e-17 Parkinson's disease; CRC cis rs6951245 1.000 rs80212261 chr7:1114012 C/T cg21664854 chr7:1097933 C7orf50;GPR146 0.78 8.76 0.43 1.05e-16 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs440932 0.717 rs330944 chr8:9021293 C/T cg06636001 chr8:8085503 FLJ10661 0.57 8.15 0.41 7.66e-15 High light scatter reticulocyte percentage of red cells; CRC cis rs9487051 0.735 rs380774 chr6:109519623 C/T cg21918786 chr6:109611834 NA -0.35 -6.05 -0.32 3.9e-9 Reticulocyte fraction of red cells; CRC cis rs853679 1.000 rs6905391 chr6:28262686 G/A cg06470822 chr6:28175283 NA 0.64 6.5 0.34 2.98e-10 Depression; CRC cis rs6076065 0.755 rs6076071 chr20:23406380 A/C cg11657817 chr20:23433608 CST11 0.43 6.32 0.33 8.59e-10 Facial morphology (factor 15, philtrum width); CRC cis rs1059312 0.771 rs11059922 chr12:129290418 C/T cg09035930 chr12:129282057 SLC15A4 0.52 8.87 0.44 4.61e-17 Systemic lupus erythematosus; CRC cis rs2811415 0.597 rs10934847 chr3:127788955 G/A cg13719885 chr3:127795394 NA -0.39 -5.98 -0.31 5.78e-9 Lung function (FEV1/FVC); CRC cis rs6951245 1.000 rs28399710 chr7:1070631 G/T cg21664854 chr7:1097933 C7orf50;GPR146 0.79 8.92 0.44 3.39e-17 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg27181079 chr12:10766103 MAGOHB 0.47 7.38 0.38 1.32e-12 Liver disease severity in Alagille syndrome; CRC cis rs10504229 0.683 rs34804288 chr8:58117570 C/A cg05313129 chr8:58192883 C8orf71 -0.43 -6.11 -0.32 2.74e-9 Developmental language disorder (linguistic errors); CRC cis rs4803468 1.000 rs17318666 chr19:41940342 T/G cg09537434 chr19:41945824 ATP5SL 0.97 18.25 0.71 6.72e-52 Height; CRC cis rs6840360 0.837 rs13137669 chr4:152710943 A/G cg09659197 chr4:152720779 NA 0.49 10.42 0.5 3.75e-22 Intelligence (multi-trait analysis); CRC cis rs6743376 0.556 rs2515401 chr2:113820476 C/T cg09040174 chr2:113837401 NA -0.41 -5.91 -0.31 8.59e-9 Inflammatory biomarkers; CRC cis rs9747201 1.000 rs9747668 chr17:80161081 A/G cg14673194 chr17:80132900 CCDC57 -0.51 -6.79 -0.35 5.12e-11 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs7937682 0.889 rs7926485 chr11:111536670 G/A cg19812747 chr11:111475976 SIK2 -0.57 -9.89 -0.48 2.34e-20 Primary sclerosing cholangitis; CRC cis rs8062405 0.755 rs12445823 chr16:28588049 A/C cg16576597 chr16:28551801 NUPR1 0.57 8.47 0.42 8.25e-16 Cognitive ability (multi-trait analysis);Cognitive ability; CRC cis rs1129187 0.755 rs2274517 chr6:42932715 A/G cg02353165 chr6:42928485 GNMT -0.73 -12.63 -0.57 4.31e-30 Alzheimer's disease in APOE e4+ carriers; CRC cis rs459571 0.959 rs2073818 chr9:136918662 C/A cg13789015 chr9:136890014 NCRNA00094 0.44 5.84 0.31 1.26e-8 Platelet distribution width; CRC trans rs629535 0.783 rs658407 chr8:70035247 T/C cg21567404 chr3:27674614 NA 0.95 16.08 0.66 2.35e-43 Dupuytren's disease; CRC cis rs875971 0.545 rs6460276 chr7:65647277 G/A cg18876405 chr7:65276391 NA 0.46 6.49 0.34 3.24e-10 Aortic root size; CRC cis rs12540874 0.542 rs3807562 chr7:50566671 G/A cg14593290 chr7:50529359 DDC -0.49 -7.14 -0.37 6.02e-12 Systemic sclerosis; CRC cis rs1570884 0.857 rs4942848 chr13:50141345 A/G cg08779649 chr13:50194554 NA -0.31 -6.1 -0.32 3.01e-9 Sum basophil neutrophil counts;Sum neutrophil eosinophil counts;Neutrophil count;Myeloid white cell count;Granulocyte count; CRC trans rs5756813 0.903 rs13054052 chr22:38130385 A/C cg19894588 chr14:64061835 NA 0.53 7.84 0.4 6.13e-14 Optic cup area;Vertical cup-disc ratio; CRC cis rs13217239 0.574 rs9366680 chr6:27006123 A/T cg12292205 chr6:26970375 C6orf41 0.55 9.06 0.45 1.21e-17 Schizophrenia; CRC cis rs7178572 0.568 rs4886856 chr15:77510585 A/G cg22256960 chr15:77711686 NA -0.66 -9.54 -0.47 3.38e-19 Type 2 diabetes; CRC cis rs6433857 0.594 rs736019 chr2:181526568 A/C cg23363182 chr2:181467187 NA 0.44 6.75 0.35 6.65e-11 Body mass index; CRC cis rs9648716 1.000 rs7793758 chr7:140603996 T/C cg10747023 chr7:140774559 NA 0.45 5.9 0.31 9.21e-9 Type 2 diabetes; CRC cis rs17095355 1.000 rs2122517 chr10:111754787 C/T cg00817464 chr10:111662876 XPNPEP1 -0.61 -8.56 -0.43 4.38e-16 Biliary atresia; CRC cis rs2742540 0.505 rs2742493 chr11:8967592 A/C cg14711859 chr11:8959438 ASCL3 -0.59 -11.44 -0.53 9.37e-26 Hematocrit; CRC cis rs523522 0.962 rs687873 chr12:121019634 G/A cg27279351 chr12:120934652 DYNLL1 0.75 10.75 0.51 2.64e-23 High light scatter reticulocyte count; CRC cis rs826838 0.616 rs7966266 chr12:38626138 G/A cg13010199 chr12:38710504 ALG10B -0.42 -6.03 -0.32 4.33e-9 Heart rate; CRC cis rs10071761 0.513 rs12514900 chr5:40363876 A/G cg09067459 chr5:40385259 NA -0.53 -7.11 -0.37 7.18e-12 Selective IgA deficiency; CRC cis rs2880765 0.546 rs36098649 chr15:86056807 C/T cg10818794 chr15:86012489 AKAP13 -0.43 -6.2 -0.32 1.71e-9 Coronary artery disease; CRC cis rs6973256 0.897 rs2991242 chr7:133336459 A/T cg10665199 chr7:133106180 EXOC4 -0.37 -5.68 -0.3 2.9e-8 Intelligence (multi-trait analysis); CRC cis rs12893668 0.703 rs729438 chr14:104092789 A/G cg08213375 chr14:104286397 PPP1R13B -0.4 -6.41 -0.33 5.17e-10 Reticulocyte count; CRC cis rs10504229 0.953 rs57131327 chr8:58171895 T/C cg22535103 chr8:58192502 C8orf71 -0.82 -12.27 -0.56 9.63e-29 Developmental language disorder (linguistic errors); CRC cis rs2204008 0.774 rs10400552 chr12:38393577 C/G cg26384229 chr12:38710491 ALG10B 0.68 9.59 0.47 2.28e-19 Bladder cancer; CRC cis rs561341 0.941 rs501773 chr17:30314435 T/G cg23018236 chr17:30244563 NA -0.58 -7.7 -0.39 1.64e-13 Hip circumference adjusted for BMI; CRC cis rs17767392 0.958 rs61989367 chr14:71907295 G/A cg13720639 chr14:72061746 SIPA1L1 -0.55 -7.05 -0.36 1.07e-11 Mitral valve prolapse; CRC cis rs2062225 1.000 rs1384796 chr2:111771873 C/T cg11729679 chr2:111877065 BCL2L11 -0.56 -5.62 -0.3 4.08e-8 Monocyte count; CRC cis rs8005677 1.000 rs4981449 chr14:23388871 C/G cg25600027 chr14:23388339 RBM23 -0.53 -8.3 -0.42 2.72e-15 Cognitive ability (multi-trait analysis); CRC cis rs17095355 1.000 rs7067604 chr10:111734665 G/A cg00817464 chr10:111662876 XPNPEP1 -0.61 -7.63 -0.39 2.52e-13 Biliary atresia; CRC cis rs75422866 0.510 rs75424057 chr12:48131077 G/A cg14736327 chr12:48174669 SLC48A1 -0.77 -6.25 -0.33 1.29e-9 Pneumonia; CRC cis rs1552244 0.882 rs56332224 chr3:10037321 G/A cg02579736 chr3:10068473 FANCD2;CIDECP 0.95 12.37 0.56 4.13e-29 Alzheimer's disease; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg24293976 chr12:111843567 SH2B3 0.38 6.09 0.32 3.13e-9 Liver disease severity in Alagille syndrome; CRC cis rs597539 0.521 rs2060982 chr11:68612927 A/G cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.47 7.19 0.37 4.26e-12 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs6964587 1.000 rs28410528 chr7:91647390 A/G cg17063962 chr7:91808500 NA 0.8 14.27 0.62 2.79e-36 Breast cancer; CRC cis rs2019137 0.539 rs11123170 chr2:113978940 C/G cg21550016 chr2:113992930 PAX8;LOC440839;LOC654433 0.7 10.51 0.5 1.82e-22 Lymphocyte counts; CRC cis rs3824867 1.000 rs3824867 chr11:47468569 A/G cg05585544 chr11:47624801 NA -0.43 -6.8 -0.35 4.98e-11 Mean corpuscular hemoglobin; CRC cis rs12497850 0.897 rs9850134 chr3:48957147 A/G cg07636037 chr3:49044803 WDR6 1.03 18.47 0.71 9.49e-53 Parkinson's disease; CRC cis rs6951245 0.935 rs11766669 chr7:1063593 C/T cg24642844 chr7:1081250 C7orf50 -0.77 -9.32 -0.46 1.73e-18 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs2979489 0.891 rs16877096 chr8:30364388 T/C cg26383811 chr8:30366931 RBPMS -0.76 -11.65 -0.54 1.66e-26 Mean corpuscular hemoglobin;Plateletcrit;Neutrophil count;Granulocyte count;Sum basophil neutrophil counts;Mean corpuscular volume;Myeloid white cell count;Sum neutrophil eosinophil counts; CRC cis rs4713118 0.869 rs9283883 chr6:27715470 T/A cg26587870 chr6:27730563 NA -0.44 -6.75 -0.35 6.5e-11 Parkinson's disease; CRC trans rs2689154 1.000 rs2689154 chr1:238908353 C/G cg24385694 chr6:4282346 NA 0.38 6.11 0.32 2.84e-9 Pancreatic cancer; CRC cis rs2204008 0.502 rs2387275 chr12:38142836 G/A cg13010199 chr12:38710504 ALG10B 0.45 5.74 0.3 2.14e-8 Bladder cancer; CRC cis rs477895 1.000 rs34292685 chr11:64049021 C/T cg23719950 chr11:63933701 MACROD1 -0.57 -6.09 -0.32 3.11e-9 Mean platelet volume; CRC cis rs9818758 0.607 rs56004653 chr3:49072228 T/C cg07636037 chr3:49044803 WDR6 -0.84 -6.02 -0.32 4.57e-9 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; CRC cis rs1008375 0.902 rs12503164 chr4:17656107 C/T cg04450456 chr4:17643702 FAM184B 0.4 6.46 0.34 3.75e-10 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs11758351 0.929 rs75475698 chr6:26190609 C/G cg01420254 chr6:26195488 NA 0.81 8.55 0.43 4.7e-16 Gout;Renal underexcretion gout; CRC cis rs12762955 0.529 rs2387213 chr10:1051420 C/T cg19847866 chr10:1019161 NA -0.42 -6.0 -0.31 5.08e-9 Response to angiotensin II receptor blocker therapy; CRC cis rs73206853 0.764 rs56838584 chr12:110666136 A/G cg12870014 chr12:110450643 ANKRD13A 0.83 10.4 0.5 4.37e-22 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC cis rs6831352 0.801 rs2602897 chr4:100046293 A/T cg12011299 chr4:100065546 ADH4 0.49 9.27 0.45 2.61e-18 Alcohol dependence; CRC cis rs2832191 0.597 rs8127842 chr21:30516461 G/A cg08807101 chr21:30365312 RNF160 -0.52 -7.18 -0.37 4.76e-12 Dental caries; CRC cis rs172166 0.769 rs149965 chr6:28018689 T/A cg02683197 chr6:28174875 NA 0.62 8.46 0.42 8.99e-16 Cardiac Troponin-T levels; CRC cis rs2153535 0.601 rs9502719 chr6:8541032 A/G cg21535247 chr6:8435926 SLC35B3 0.5 7.77 0.39 1.01e-13 Motion sickness; CRC cis rs2721195 0.967 rs1985022 chr8:145684031 C/T cg26752003 chr8:145688521 CYHR1 -0.57 -9.33 -0.46 1.59e-18 Age at first birth; CRC cis rs8062405 0.754 rs3859172 chr16:28566158 G/T cg16576597 chr16:28551801 NUPR1 0.46 6.96 0.36 1.88e-11 Cognitive ability (multi-trait analysis);Cognitive ability; CRC cis rs875971 1.000 rs4718343 chr7:65874288 T/G cg12463550 chr7:65579703 CRCP 0.48 6.96 0.36 1.89e-11 Aortic root size; CRC cis rs4819052 0.851 rs13052312 chr21:46662359 T/C cg02159808 chr21:46707872 POFUT2;LOC642852 0.49 6.42 0.33 4.89e-10 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs4713118 0.597 rs172166 chr6:28020820 C/G cg06470822 chr6:28175283 NA 0.91 13.28 0.59 1.54e-32 Parkinson's disease; CRC cis rs875971 0.862 rs1695820 chr7:65844563 G/A cg18876405 chr7:65276391 NA 0.51 8.56 0.43 4.3e-16 Aortic root size; CRC cis rs7737355 0.853 rs7730810 chr5:130781179 T/C cg25547332 chr5:131281432 NA -0.36 -5.74 -0.3 2.11e-8 Life satisfaction; CRC cis rs6502050 0.835 rs4789676 chr17:80123078 C/T cg13198984 chr17:80129470 CCDC57 0.47 8.35 0.42 1.88e-15 Life satisfaction; CRC cis rs6867032 1.000 rs4398675 chr5:2015816 G/A cg26168224 chr5:2018326 NA 1.0 18.47 0.71 9.02e-53 Gut microbiome composition (winter); CRC cis rs314370 0.818 rs13245899 chr7:100497131 A/G cg10426581 chr7:100472382 SRRT 0.59 7.17 0.37 5.01e-12 Resting heart rate; CRC cis rs6089584 0.888 rs6587283 chr20:60613727 A/C cg12751644 chr20:60527061 NA -0.39 -6.09 -0.32 3.15e-9 Body mass index; CRC cis rs514406 0.861 rs1412706 chr1:53237721 G/A cg08859206 chr1:53392774 SCP2 0.44 6.74 0.35 6.94e-11 Monocyte count; CRC cis rs12594515 1.000 rs11070467 chr15:45985001 C/T cg22117107 chr15:45993392 NA 0.44 8.7 0.43 1.66e-16 Waist circumference;Weight; CRC trans rs11026407 0.967 rs7127246 chr11:22060228 C/G cg05872234 chr4:48390346 SLAIN2 -0.54 -6.04 -0.32 4.24e-9 Plasma thyroid-stimulating hormone levels; CRC cis rs12477438 0.700 rs12467679 chr2:99654449 G/A cg14399236 chr2:99771627 LIPT1;TSGA10 -0.73 -10.32 -0.49 8.33e-22 Chronic sinus infection; CRC cis rs780096 0.526 rs11126999 chr2:27670307 G/A cg24768116 chr2:27665128 KRTCAP3 -0.36 -7.75 -0.39 1.13e-13 Total body bone mineral density; CRC cis rs35306767 0.623 rs36062650 chr10:1142571 T/C cg20503657 chr10:835505 NA 0.52 7.25 0.37 3.04e-12 Eosinophil percentage of granulocytes; CRC cis rs72615157 0.697 rs2056726 chr7:99780283 G/A cg16268157 chr7:99778414 STAG3 -0.43 -5.69 -0.3 2.74e-8 Lung function (FEV1/FVC); CRC trans rs1550115 0.524 rs113939247 chr2:25029179 G/A cg08894410 chr5:99715943 LOC100133050 0.48 6.27 0.33 1.12e-9 Coronary artery disease; CRC cis rs6123683 0.711 rs2180783 chr20:55827144 C/A cg13236649 chr20:55835020 BMP7 0.48 7.46 0.38 7.84e-13 Facial morphology (factor 5, width of mouth relative to central midface); CRC cis rs1062746 0.544 rs3762182 chr16:87326113 A/G cg02258303 chr16:87377426 FBXO31 0.49 7.03 0.36 1.19e-11 Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 2 peripheral neuropathy); CRC cis rs6500602 0.819 rs3747580 chr16:4455675 G/A cg08645402 chr16:4508243 NA 0.53 7.4 0.38 1.18e-12 Schizophrenia; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg04094107 chr15:73976560 CD276 0.38 6.47 0.34 3.61e-10 Liver disease severity in Alagille syndrome; CRC cis rs7666738 0.830 rs10011009 chr4:98981749 G/A cg05340658 chr4:99064831 C4orf37 0.58 8.82 0.44 6.61e-17 Colonoscopy-negative controls vs population controls; CRC cis rs9649465 0.967 rs7791183 chr7:123343719 A/G cg03229431 chr7:123269106 ASB15 -0.36 -5.64 -0.3 3.7e-8 Migraine; CRC cis rs16975963 0.843 rs112628349 chr19:38268238 G/C cg15135657 chr19:38346511 NA -0.44 -5.9 -0.31 9.09e-9 Longevity; CRC cis rs2228479 0.850 rs17226519 chr16:89839854 T/C cg06656553 chr16:89960601 TCF25 -0.7 -5.97 -0.31 6.14e-9 Skin colour saturation; CRC cis rs7617773 0.817 rs6806112 chr3:48276077 A/T cg11946769 chr3:48343235 NME6 0.56 8.04 0.41 1.61e-14 Coronary artery disease; CRC trans rs7580658 0.614 rs7585198 chr2:127962635 C/T cg22713327 chr12:120703336 PXN -0.39 -6.0 -0.31 5.26e-9 Protein C levels; CRC cis rs62064224 0.614 rs8065246 chr17:30682274 T/C cg25809561 chr17:30822961 MYO1D 0.52 9.15 0.45 5.97e-18 Schizophrenia; CRC trans rs7647973 0.554 rs13096480 chr3:49658084 A/G cg21659725 chr3:3221576 CRBN -0.66 -7.31 -0.37 2.03e-12 Menarche (age at onset); CRC trans rs6928289 0.527 rs9321597 chr6:137672746 A/G cg24169820 chr12:121711996 CAMKK2 -0.39 -6.0 -0.31 5.32e-9 Thiazide-induced adverse metabolic effects in hypertensive patients; CRC cis rs2072510 0.593 rs2540498 chr12:96400569 T/A cg15438951 chr12:96389694 HAL -0.49 -6.23 -0.33 1.39e-9 Metabolite levels (small molecules and protein measures); CRC cis rs968567 0.906 rs61897793 chr11:61599347 G/A cg00603274 chr11:61596626 FADS2 -0.85 -9.45 -0.46 6.65e-19 Blood metabolite levels;Rheumatoid arthritis;Vitiligo;Glycerophospholipid levels; CRC cis rs989128 0.614 rs1132414 chr17:48628092 A/G cg16068336 chr17:48637367 CACNA1G -0.54 -7.73 -0.39 1.36e-13 Type 2 diabetes; CRC trans rs11039798 0.614 rs116427493 chr11:48776141 C/T cg03929089 chr4:120376271 NA 0.63 6.14 0.32 2.43e-9 Axial length; CRC cis rs2732480 0.500 rs2932093 chr12:48648271 G/T cg21466736 chr12:48725269 NA -0.58 -8.54 -0.43 4.88e-16 Hemoglobin concentration;Red blood cell count;Hematocrit; CRC cis rs2439831 0.850 rs16977798 chr15:44151948 C/T cg02155558 chr15:43621948 ADAL;LCMT2 0.76 7.92 0.4 3.78e-14 Lung cancer in ever smokers; CRC cis rs2762353 0.902 rs3799344 chr6:25786993 C/T cg12310025 chr6:25882481 NA 0.47 6.93 0.36 2.28e-11 Blood metabolite levels; CRC cis rs704795 0.867 rs7566052 chr2:27628635 A/G cg22903471 chr2:27725779 GCKR -0.38 -6.24 -0.33 1.37e-9 Menopause (age at onset); CRC cis rs2276314 1.000 rs4799835 chr18:33571268 G/A cg19628046 chr18:33552617 C18orf21 0.54 6.96 0.36 1.79e-11 Endometriosis;Drug-induced torsades de pointes; CRC cis rs79349575 0.783 rs12602746 chr17:47031741 A/C cg00947319 chr17:47005597 UBE2Z -0.33 -5.67 -0.3 3.19e-8 Type 2 diabetes; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg05663122 chr19:59055778 TRIM28 0.47 6.71 0.35 8.3e-11 Anxiety disorder; CRC cis rs9292777 0.720 rs57970171 chr5:40401030 A/T cg09067459 chr5:40385259 NA -0.54 -8.98 -0.44 2.1e-17 Crohn's disease;Multiple sclerosis; CRC cis rs7659604 1.000 rs7659604 chr4:122665514 A/G cg19748678 chr4:122722346 EXOSC9 -0.51 -8.1 -0.41 1.12e-14 Type 2 diabetes; CRC cis rs3820068 0.603 rs6429767 chr1:15963334 G/A cg13390004 chr1:15929781 NA 0.5 7.07 0.36 9.19e-12 Systolic blood pressure; CRC cis rs801193 0.569 rs2013908 chr7:66121069 A/T cg12463550 chr7:65579703 CRCP -0.46 -6.16 -0.32 2.1e-9 Aortic root size; CRC trans rs55675132 0.548 rs10494169 chr1:115363532 T/C cg25493687 chr8:27288214 PTK2B 0.47 6.04 0.32 4.08e-9 Schizophrenia; CRC cis rs12908161 1.000 rs35316992 chr15:85248133 A/G cg11189052 chr15:85197271 WDR73 0.62 8.85 0.44 5.51e-17 Schizophrenia; CRC cis rs875971 0.767 rs12668005 chr7:65909021 T/C cg00343986 chr7:65444356 GUSB 0.44 6.07 0.32 3.6e-9 Aortic root size; CRC cis rs9303401 0.659 rs7210432 chr17:56668170 C/T cg02118635 chr17:56770003 RAD51C;TEX14 0.78 9.61 0.47 1.92e-19 Cognitive test performance; CRC cis rs3540 0.960 rs2238329 chr15:91028401 G/A cg04176472 chr15:90893244 GABARAPL3 0.34 5.85 0.31 1.2e-8 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; CRC cis rs1552244 0.882 rs6443276 chr3:10008905 C/A cg18598329 chr3:10140678 FANCD2;C3orf24 -0.81 -10.75 -0.51 2.71e-23 Alzheimer's disease; CRC cis rs7786808 0.536 rs4909210 chr7:158194376 T/C cg15440763 chr7:158190612 PTPRN2 0.47 7.56 0.38 4.05e-13 Obesity-related traits; CRC cis rs6502050 0.799 rs4789681 chr17:80100546 G/A cg02741985 chr17:80059408 CCDC57 0.43 7.15 0.37 5.66e-12 Life satisfaction; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg10841076 chr16:3174662 NA 0.47 6.78 0.35 5.63e-11 Response to antipsychotic treatment; CRC cis rs208520 0.802 rs4710314 chr6:66883656 G/A cg07460842 chr6:66804631 NA -0.93 -12.55 -0.57 8.48e-30 Exhaled nitric oxide output; CRC cis rs11191205 0.954 rs11191191 chr10:103800979 G/A cg15320455 chr10:103880129 LDB1 0.66 7.06 0.36 1.02e-11 Intelligence (multi-trait analysis); CRC cis rs2228479 0.702 rs11076621 chr16:89837927 A/G cg06558623 chr16:89946397 TCF25 1.13 10.76 0.51 2.47e-23 Skin colour saturation; CRC cis rs4862750 0.914 rs1991255 chr4:187875340 G/A cg03452623 chr4:187889614 NA -0.9 -20.37 -0.75 2.89e-60 Lobe attachment (rater-scored or self-reported); CRC trans rs1005277 0.579 rs2505196 chr10:38393563 G/A cg23533926 chr12:111358616 MYL2 -0.52 -7.84 -0.4 6.17e-14 Extrinsic epigenetic age acceleration; CRC cis rs2228479 0.850 rs11640209 chr16:89807828 C/A cg19635926 chr16:89946313 TCF25 0.66 5.98 0.31 5.71e-9 Skin colour saturation; CRC cis rs4563143 0.514 rs73029079 chr19:29294903 A/G cg14983838 chr19:29218262 NA 0.52 7.0 0.36 1.45e-11 Methadone dose in opioid dependence; CRC cis rs3733585 0.699 rs4473653 chr4:9971058 A/G cg00071950 chr4:10020882 SLC2A9 -0.56 -9.83 -0.48 3.55e-20 Cleft plate (environmental tobacco smoke interaction); CRC cis rs68170813 0.559 rs2023892 chr7:106847686 C/T cg02696742 chr7:106810147 HBP1 0.53 6.12 0.32 2.59e-9 Coronary artery disease; CRC trans rs4256159 1.000 rs75407508 chr3:18825612 G/A cg01763821 chr15:59397510 CCNB2 -0.63 -5.98 -0.31 5.76e-9 Crohn's disease;Inflammatory bowel disease; CRC cis rs6582630 0.585 rs12422588 chr12:38478675 C/T cg26384229 chr12:38710491 ALG10B -0.53 -7.56 -0.38 4e-13 Drug-induced liver injury (flucloxacillin); CRC cis rs10504229 0.728 rs17804365 chr8:58151537 C/A cg24829409 chr8:58192753 C8orf71 -0.58 -7.96 -0.4 2.86e-14 Developmental language disorder (linguistic errors); CRC cis rs3760982 1.000 rs4802200 chr19:44289518 G/A cg11993925 chr19:44307056 LYPD5 0.49 8.14 0.41 8.12e-15 Breast cancer (estrogen-receptor negative);Breast cancer; CRC cis rs9875589 0.915 rs9835402 chr3:13954396 A/G cg19554555 chr3:13937349 NA 0.44 6.61 0.34 1.58e-10 Ovarian reserve; CRC cis rs9443645 0.527 rs9343861 chr6:79744868 C/A cg09184832 chr6:79620586 NA -0.46 -7.82 -0.4 7.32e-14 Intelligence (multi-trait analysis); CRC cis rs9814567 1.000 rs4368544 chr3:134300014 C/T cg06109529 chr3:134205091 CEP63;ANAPC13 0.83 12.18 0.56 1.98e-28 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs4332037 0.575 rs55952733 chr7:2070680 G/A cg21155852 chr7:2048760 MAD1L1 -0.5 -6.77 -0.35 5.83e-11 Bipolar disorder; CRC cis rs2404602 0.692 rs8043474 chr15:76974723 T/C cg03037974 chr15:76606532 NA 0.7 12.39 0.56 3.28e-29 Blood metabolite levels; CRC cis rs7666738 0.830 rs13121558 chr4:99002848 G/A cg05340658 chr4:99064831 C4orf37 0.61 9.53 0.46 3.72e-19 Colonoscopy-negative controls vs population controls; CRC cis rs4988958 0.565 rs6732138 chr2:103009662 G/A cg03938978 chr2:103052716 IL18RAP 0.59 10.2 0.49 2.14e-21 Asthma (childhood onset); CRC cis rs13108904 0.870 rs12499546 chr4:1255194 C/T cg02018176 chr4:1364513 KIAA1530 0.45 7.56 0.38 4.03e-13 Obesity-related traits; CRC cis rs62244186 0.683 rs6766334 chr3:44567065 T/C cg10263370 chr3:44754102 ZNF502 -0.36 -5.96 -0.31 6.46e-9 Depressive symptoms; CRC cis rs9326248 0.953 rs488962 chr11:117072525 C/T cg15534755 chr11:117069859 TAGLN -0.34 -6.29 -0.33 9.86e-10 Blood protein levels; CRC trans rs10403021 0.855 rs4805433 chr19:30069763 C/T cg22044635 chr17:76557109 DNAH17 0.43 5.99 0.31 5.47e-9 Diabetic retinopathy; CRC cis rs8060686 0.641 rs111632263 chr16:68233122 T/A cg08314208 chr16:67682810 RLTPR -0.54 -5.88 -0.31 9.91e-9 HDL cholesterol;Metabolic syndrome; CRC trans rs7726839 0.540 rs72707016 chr5:665148 A/G cg25482853 chr8:67687455 SGK3 1.16 13.2 0.59 3.15e-32 Obesity-related traits; CRC cis rs2050392 0.762 rs306587 chr10:30722908 G/C cg25182066 chr10:30743637 MAP3K8 -0.41 -5.97 -0.31 6.06e-9 Inflammatory bowel disease; CRC cis rs7829975 0.514 rs2979151 chr8:8258019 A/G cg14979609 chr8:8086686 FLJ10661 0.38 5.95 0.31 6.87e-9 Mood instability; CRC cis rs4900538 0.855 rs1190537 chr14:102887816 C/T cg18135206 chr14:102964638 TECPR2 -0.95 -16.9 -0.68 1.41e-46 Mean corpuscular volume;Mean corpuscular hemoglobin; CRC cis rs801193 0.569 rs2707847 chr7:66202871 C/G cg18252515 chr7:66147081 NA -0.41 -5.81 -0.3 1.5e-8 Aortic root size; CRC cis rs853679 0.517 rs6941992 chr6:28106141 T/C cg12273811 chr6:28175739 NA 0.73 9.36 0.46 1.34e-18 Depression; CRC cis rs12476592 0.602 rs4671508 chr2:63654140 C/T cg10828910 chr2:63850056 LOC388955 0.51 6.22 0.32 1.54e-9 Childhood ear infection; CRC cis rs7591163 1.000 rs940341 chr2:228724726 A/G cg20647610 chr2:228736258 WDR69 -0.47 -6.46 -0.34 3.75e-10 Blood pressure; CRC cis rs3617 0.625 rs11922961 chr3:52868610 T/C cg05573699 chr3:52720067 GNL3;PBRM1 0.37 5.62 0.3 4.12e-8 Red blood cell count;Autism spectrum disorder or schizophrenia; CRC cis rs947211 0.948 rs863725 chr1:205751196 C/T cg07157834 chr1:205819609 PM20D1 0.44 6.03 0.32 4.34e-9 Parkinson's disease; CRC cis rs4862750 0.872 rs7679956 chr4:187900229 C/T cg10295955 chr4:187884368 NA -1.02 -24.87 -0.81 1.52e-77 Lobe attachment (rater-scored or self-reported); CRC cis rs3741404 0.560 rs17699798 chr11:63898806 C/G cg15107132 chr11:63991130 FERMT3 0.45 7.73 0.39 1.34e-13 Platelet count; CRC cis rs2411233 1.000 rs12910426 chr15:39278738 A/G cg23129342 chr15:39283510 NA 0.33 6.02 0.32 4.6e-9 Platelet count; CRC cis rs2976388 0.647 rs2585138 chr8:143808951 C/T cg12516270 chr8:143859308 LYNX1 0.44 7.74 0.39 1.2e-13 Urinary tract infection frequency; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg12103840 chr6:108582260 SNX3 0.5 7.23 0.37 3.34e-12 Anxiety disorder; CRC cis rs10540 0.570 rs8176330 chr11:535798 G/A cg19913688 chr11:428466 ANO9 -0.65 -6.58 -0.34 1.83e-10 Body mass index; CRC cis rs11585357 0.947 rs6684387 chr1:17611519 T/C cg08277548 chr1:17600880 PADI3 0.7 9.69 0.47 1.09e-19 Hair shape; CRC cis rs1059312 0.808 rs2306683 chr12:129299675 C/G cg21616243 chr12:129299702 MGC16384;SLC15A4 -0.77 -13.51 -0.6 2.11e-33 Systemic lupus erythematosus; CRC cis rs7923609 0.936 rs10761779 chr10:65274927 A/G cg08743896 chr10:65200160 JMJD1C -0.4 -5.72 -0.3 2.37e-8 Educational attainment;Liver enzyme levels (alkaline phosphatase); CRC cis rs9858542 0.953 rs4625 chr3:49572140 A/G cg07274523 chr3:49395745 GPX1 0.47 6.41 0.33 5.15e-10 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs1448094 0.512 rs7309500 chr12:86249647 C/T cg19622623 chr12:86230825 RASSF9 -0.41 -6.76 -0.35 6.45e-11 Major depressive disorder; CRC cis rs736408 0.509 rs3774349 chr3:52722335 A/C cg05573699 chr3:52720067 GNL3;PBRM1 -0.55 -8.42 -0.42 1.15e-15 Bipolar disorder; CRC cis rs2579500 0.844 rs2708975 chr2:97184160 G/A cg23100626 chr2:96804247 ASTL 0.24 5.72 0.3 2.43e-8 Eosinophil counts;Eosinophil percentage of white cells; CRC cis rs853679 0.546 rs200949 chr6:27835435 A/G cg06470822 chr6:28175283 NA 0.69 6.51 0.34 2.85e-10 Depression; CRC cis rs6445967 0.932 rs13093235 chr3:58296706 A/T cg23715586 chr3:58305044 RPP14 0.37 5.96 0.31 6.33e-9 Platelet count; CRC cis rs6495122 0.501 rs12904227 chr15:75387048 A/C cg18612461 chr15:75251733 NA -0.39 -6.06 -0.32 3.69e-9 Caffeine consumption;Diastolic blood pressure;Coffee consumption; CRC cis rs4757319 0.512 rs4360688 chr11:15441149 A/G cg03245590 chr11:15329459 NA 0.39 6.82 0.35 4.51e-11 Breast cancer; CRC cis rs7647973 0.559 rs9586 chr3:49213637 C/T cg07690219 chr3:49449608 TCTA;RHOA -0.52 -5.83 -0.31 1.33e-8 Menarche (age at onset); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg24763869 chr17:3572311 TMEM93;TAX1BP3 0.41 6.08 0.32 3.33e-9 Intelligence (multi-trait analysis); CRC cis rs9914988 0.943 rs4795467 chr17:27180784 C/T cg12682573 chr17:27188876 MIR451;MIR144 0.45 5.62 0.3 4.06e-8 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs10865541 1.000 rs11692425 chr2:3395383 A/G cg22182287 chr2:3452347 TTC15 0.38 5.9 0.31 9.02e-9 Obesity-related traits; CRC cis rs10751667 0.666 rs4074231 chr11:978219 G/C cg01483505 chr11:975446 AP2A2 0.46 7.66 0.39 2.11e-13 Alzheimer's disease (late onset); CRC cis rs10751667 0.580 rs11246363 chr11:971667 T/C cg01483505 chr11:975446 AP2A2 0.46 7.6 0.39 3.17e-13 Alzheimer's disease (late onset); CRC cis rs425277 0.606 rs2257182 chr1:2082566 C/T cg24578937 chr1:2090814 PRKCZ -0.36 -6.68 -0.35 1.03e-10 Height; CRC cis rs8072100 0.817 rs12449647 chr17:45548958 C/A cg08085267 chr17:45401833 C17orf57 -0.62 -9.89 -0.48 2.39e-20 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs7746199 0.736 rs6904596 chr6:27491299 G/A cg03623178 chr6:28175578 NA 0.75 5.94 0.31 7.17e-9 Gait speed in old age;Autism spectrum disorder or schizophrenia; CRC cis rs6502050 0.871 rs8066137 chr17:80074316 T/C cg13198984 chr17:80129470 CCDC57 -0.48 -8.57 -0.43 4.01e-16 Life satisfaction; CRC cis rs11191205 0.686 rs12358045 chr10:103399708 C/T cg15320455 chr10:103880129 LDB1 0.56 6.19 0.32 1.77e-9 Intelligence (multi-trait analysis); CRC cis rs4713118 0.586 rs9468290 chr6:28087674 C/T cg23161317 chr6:28129485 ZNF389 0.54 6.56 0.34 2.12e-10 Parkinson's disease; CRC cis rs9487051 1.000 rs9400273 chr6:109632799 A/G cg01475377 chr6:109611718 NA -0.44 -7.73 -0.39 1.31e-13 Reticulocyte fraction of red cells; CRC cis rs597539 0.652 rs507520 chr11:68666054 C/T cg04772025 chr11:68637568 NA 0.49 7.34 0.38 1.68e-12 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs4757319 0.515 rs58697209 chr11:15431540 C/T cg03245590 chr11:15329459 NA 0.53 9.26 0.45 2.75e-18 Breast cancer; CRC cis rs1552244 1.000 rs6442148 chr3:10078289 G/C cg00166722 chr3:10149974 C3orf24 0.66 9.23 0.45 3.41e-18 Alzheimer's disease; CRC cis rs4664293 0.805 rs7593273 chr2:160605860 T/G cg08347373 chr2:160653686 CD302 -0.47 -7.44 -0.38 9.06e-13 Monocyte percentage of white cells; CRC cis rs7255436 0.965 rs11668346 chr19:8450854 A/T cg16745616 chr19:8428856 ANGPTL4 -0.45 -7.04 -0.36 1.16e-11 HDL cholesterol; CRC cis rs1878931 0.531 rs9635548 chr16:3417156 G/A cg26668626 chr16:3451006 ZNF174;ZNF434 0.7 9.62 0.47 1.82e-19 Body mass index (adult); CRC trans rs3780486 0.846 rs7036812 chr9:33143822 T/C cg20290983 chr6:43655470 MRPS18A 1.18 25.25 0.81 5.58e-79 IgG glycosylation; CRC cis rs6952808 0.895 rs12669518 chr7:1921429 G/C cg22963979 chr7:1858916 MAD1L1 -0.47 -7.19 -0.37 4.33e-12 Bipolar disorder and schizophrenia; CRC cis rs9894429 0.646 rs9904137 chr17:79613925 C/T cg21028142 chr17:79581711 NPLOC4 0.34 7.16 0.37 5.16e-12 Eye color traits; CRC cis rs1005277 0.541 rs2472177 chr10:38384015 T/G cg25517755 chr10:38738941 LOC399744 -0.41 -6.1 -0.32 3.04e-9 Extrinsic epigenetic age acceleration; CRC cis rs2549003 0.934 rs2549006 chr5:131827065 A/G cg00255919 chr5:131827918 IRF1 -0.6 -11.88 -0.55 2.59e-27 Asthma (sex interaction); CRC cis rs10504229 1.000 rs66936919 chr8:58172868 C/G cg05313129 chr8:58192883 C8orf71 -0.46 -7.07 -0.36 9.56e-12 Developmental language disorder (linguistic errors); CRC trans rs57221529 0.709 rs72706611 chr5:561146 C/A cg25482853 chr8:67687455 SGK3 1.25 15.65 0.65 1.15e-41 Lung disease severity in cystic fibrosis; CRC cis rs7487075 0.619 rs7486495 chr12:46826336 A/G cg22049899 chr12:47219821 SLC38A4 0.31 5.69 0.3 2.89e-8 Itch intensity from mosquito bite; CRC cis rs644799 0.544 rs555556 chr11:95618425 T/G cg25478527 chr11:95522999 CEP57;FAM76B 0.37 5.61 0.3 4.21e-8 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs679087 1.000 rs672107 chr12:29917266 T/A cg14258853 chr12:29935411 TMTC1 -0.45 -7.62 -0.39 2.79e-13 Schizophrenia; CRC cis rs9807989 0.839 rs3771166 chr2:102986222 G/A cg03938978 chr2:103052716 IL18RAP 0.37 6.04 0.32 4.27e-9 Asthma; CRC cis rs2404602 0.684 rs2454451 chr15:76861461 G/T cg03037974 chr15:76606532 NA 0.53 8.39 0.42 1.5e-15 Blood metabolite levels; CRC trans rs7615952 0.800 rs12489350 chr3:125644116 T/C cg07211511 chr3:129823064 LOC729375 -1.06 -17.79 -0.7 4.45e-50 Blood pressure (smoking interaction); CRC cis rs2153535 0.580 rs4960433 chr6:8523697 A/G cg21535247 chr6:8435926 SLC35B3 0.48 7.45 0.38 8.2e-13 Motion sickness; CRC cis rs57221529 0.766 rs12522303 chr5:555564 A/C cg17948913 chr5:572064 NA 0.55 6.33 0.33 7.93e-10 Lung disease severity in cystic fibrosis; CRC cis rs7618915 0.547 rs11130313 chr3:52676190 A/C cg18404041 chr3:52824283 ITIH1 -0.43 -8.82 -0.44 7.03e-17 Bipolar disorder; CRC trans rs9354308 0.966 rs1909533 chr6:66565658 G/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.47 5.98 0.31 5.9e-9 Metabolite levels; CRC cis rs523522 0.926 rs10849766 chr12:121025894 G/A cg12219531 chr12:120966889 COQ5 0.7 9.18 0.45 5.08e-18 High light scatter reticulocyte count; CRC cis rs6912958 0.781 rs2273129 chr6:88182439 T/C cg12350822 chr6:88032061 C6orf162;GJB7 -0.34 -6.46 -0.34 3.86e-10 Monocyte percentage of white cells; CRC cis rs1577917 1.000 rs35419329 chr6:86702291 G/A cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.53 -6.64 -0.34 1.32e-10 Response to antipsychotic treatment; CRC cis rs1799949 1.000 rs12936816 chr17:41301709 C/T cg05368731 chr17:41323189 NBR1 0.69 10.5 0.5 1.94e-22 Menopause (age at onset); CRC cis rs7584330 0.518 rs80282956 chr2:238447929 G/A cg14458575 chr2:238380390 NA 0.7 8.63 0.43 2.69e-16 Prostate cancer; CRC cis rs4728302 0.871 rs10259686 chr7:133633152 A/G cg10665199 chr7:133106180 EXOC4 -0.38 -5.8 -0.3 1.54e-8 Intelligence;Intelligence (multi-trait analysis); CRC cis rs972578 0.905 rs60752002 chr22:43371628 C/T cg01576275 chr22:43409880 NA -0.46 -7.36 -0.38 1.52e-12 Mean platelet volume; CRC cis rs501120 0.810 rs513391 chr10:44749708 A/C cg09554077 chr10:44749378 NA 0.89 13.21 0.59 3.04e-32 Coronary artery disease;Coronary heart disease; CRC cis rs2243480 0.901 rs313808 chr7:65499873 T/G cg12463550 chr7:65579703 CRCP 0.69 6.4 0.33 5.48e-10 Diabetic kidney disease; CRC cis rs2760061 0.819 rs708112 chr1:228192452 G/A cg18477163 chr1:228402036 OBSCN 0.42 7.01 0.36 1.32e-11 Diastolic blood pressure; CRC cis rs7113874 0.543 rs7935708 chr11:8478545 C/A cg20771178 chr11:8615675 STK33 -0.34 -5.61 -0.3 4.31e-8 Body mass index in physically active individuals;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs9929218 0.953 rs28608872 chr16:68802038 A/G cg02972257 chr16:68554789 NA 0.44 5.61 0.3 4.28e-8 Colorectal cancer; CRC cis rs56399783 0.901 rs73049380 chr7:2832845 C/T cg23627948 chr7:2760692 NA 0.48 5.73 0.3 2.23e-8 Childhood ear infection; CRC cis rs6495367 1.000 rs13380109 chr15:79378775 G/A cg17916960 chr15:79447300 NA 0.41 6.66 0.34 1.18e-10 Spherical equivalent (joint analysis main effects and education interaction); CRC cis rs7408868 1.000 rs10416389 chr19:15278674 G/C cg14696996 chr19:15285081 NOTCH3 0.96 8.96 0.44 2.53e-17 Pulse pressure; CRC cis rs9443645 0.901 rs1572585 chr6:79690576 C/T cg11833968 chr6:79620685 NA -0.36 -6.26 -0.33 1.2e-9 Intelligence (multi-trait analysis); CRC cis rs11785400 0.793 rs1137521 chr8:143739162 C/T cg10596483 chr8:143751796 JRK 0.43 5.8 0.3 1.57e-8 Schizophrenia; CRC cis rs6502050 0.799 rs28376857 chr17:80104351 G/A cg02741985 chr17:80059408 CCDC57 0.43 7.15 0.37 5.66e-12 Life satisfaction; CRC cis rs6121246 0.954 rs6058470 chr20:30416827 A/T cg18721089 chr20:30220636 NA -0.35 -5.86 -0.31 1.1e-8 Mean corpuscular hemoglobin; CRC cis rs4665809 1.000 rs1371553 chr2:26262948 G/A cg26119090 chr2:26468346 HADHA;HADHB -0.62 -7.95 -0.4 2.96e-14 Gut microbiome composition (summer); CRC cis rs3858526 0.508 rs10838734 chr11:5876325 T/G cg13902645 chr11:5959945 NA -0.66 -9.71 -0.47 9.35e-20 DNA methylation (variation); CRC cis rs798554 0.610 rs2248390 chr7:2855594 T/C cg17321639 chr7:2759063 NA -0.38 -5.85 -0.31 1.21e-8 Height; CRC cis rs889312 0.500 rs252905 chr5:56118875 C/T cg12311346 chr5:56204834 C5orf35 -0.47 -7.24 -0.37 3.14e-12 Breast cancer;Breast cancer (early onset); CRC cis rs9393692 0.676 rs806977 chr6:26189615 A/G cg13736514 chr6:26305472 NA -0.55 -9.72 -0.47 8.33e-20 Educational attainment; CRC cis rs10971721 0.731 rs72725402 chr9:33878356 G/C cg13495928 chr9:33750294 PRSS3 0.56 5.95 0.31 6.96e-9 Body mass index; CRC cis rs28386778 0.933 rs2665804 chr17:61951836 G/T cg11494091 chr17:61959527 GH2 0.59 10.09 0.49 5.02e-21 Prudent dietary pattern; CRC cis rs4308124 0.708 rs6747657 chr2:112003163 C/T cg04571233 chr2:111982156 NA -0.52 -8.06 -0.41 1.46e-14 Vitiligo; CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg19737664 chr11:537435 LRRC56 -0.51 -6.01 -0.31 4.92e-9 Diisocyanate-induced asthma; CRC cis rs6912958 0.967 rs6914299 chr6:88149176 T/G cg12350822 chr6:88032061 C6orf162;GJB7 -0.36 -6.8 -0.35 5.09e-11 Monocyte percentage of white cells; CRC cis rs1564271 0.528 rs1980756 chr10:26979371 G/C cg13837822 chr10:26931731 LOC731789 0.58 8.69 0.43 1.72e-16 Overall survival in serous epithelial ovarian cancer treated with paclitaxel and cisplatin; CRC cis rs6456156 0.526 rs3093025 chr6:167532731 A/G cg07741184 chr6:167504864 NA -0.4 -7.17 -0.37 5.11e-12 Primary biliary cholangitis; CRC cis rs35306767 0.623 rs36051896 chr10:1155747 T/C cg26597838 chr10:835615 NA 0.72 8.21 0.41 5.26e-15 Eosinophil percentage of granulocytes; CRC cis rs13108904 0.870 rs4974543 chr4:1251222 A/G cg20887711 chr4:1340912 KIAA1530 0.41 5.86 0.31 1.1e-8 Obesity-related traits; CRC cis rs10504229 0.593 rs58647001 chr8:58025132 G/A cg22535103 chr8:58192502 C8orf71 -0.47 -6.48 -0.34 3.3e-10 Developmental language disorder (linguistic errors); CRC cis rs9486719 1.000 rs12208449 chr6:96903253 A/G cg06623918 chr6:96969491 KIAA0776 0.8 9.25 0.45 2.97e-18 Migraine;Coronary artery disease; CRC cis rs12024301 0.557 rs16861414 chr1:183620393 A/G cg11505048 chr1:183622726 RGL1;APOBEC4 0.81 7.0 0.36 1.42e-11 Peripheral arterial disease (traffic-related air pollution interaction); CRC trans rs2303319 0.504 rs12470743 chr2:162611202 G/A cg03774468 chr3:140950104 ACPL2 -0.65 -6.07 -0.32 3.61e-9 Cognitive function; CRC cis rs9399135 0.967 rs9321481 chr6:135352648 C/G cg24558204 chr6:135376177 HBS1L -0.5 -7.68 -0.39 1.8e-13 Red blood cell count; CRC cis rs2252521 0.583 rs320088 chr7:29083262 C/T cg11728747 chr7:29037910 CPVL -0.47 -6.68 -0.35 1.02e-10 Cognitive performance; CRC cis rs9811920 0.638 rs796978 chr3:99564321 A/G cg07805332 chr3:99536008 MIR548G;C3orf26 0.54 8.18 0.41 6.09e-15 Axial length; CRC cis rs708547 0.836 rs1718882 chr4:57859533 C/G cg25525207 chr4:57843836 C4orf14;POLR2B -0.58 -8.42 -0.42 1.15e-15 Response to bleomycin (chromatid breaks); CRC cis rs896854 0.654 rs13281625 chr8:95972738 T/C cg09323728 chr8:95962352 TP53INP1 -0.45 -7.46 -0.38 7.88e-13 Type 2 diabetes; CRC cis rs863345 0.604 rs7555174 chr1:158487426 A/G cg12129480 chr1:158549410 OR10X1 -0.29 -6.03 -0.32 4.52e-9 Pneumococcal bacteremia; CRC cis rs2832191 0.791 rs4817270 chr21:30480368 G/A cg24692254 chr21:30365293 RNF160 -0.7 -12.39 -0.56 3.29e-29 Dental caries; CRC cis rs1997103 1.000 rs6966183 chr7:55407546 A/C cg17469321 chr7:55412551 NA 0.72 11.28 0.53 3.48e-25 QRS interval (sulfonylurea treatment interaction); CRC cis rs10256972 0.678 rs6962989 chr7:1017512 G/A cg24642844 chr7:1081250 C7orf50 -0.65 -6.93 -0.36 2.23e-11 Longevity;Endometriosis; CRC cis rs3785574 0.962 rs2584623 chr17:61906679 G/A cg06601766 chr17:61851465 DDX42;CCDC47 0.6 8.45 0.42 9.3e-16 Height; CRC cis rs2742540 0.503 rs7106539 chr11:8897533 T/G cg00186954 chr11:8933980 ST5;C11orf17 -0.6 -11.06 -0.52 2.26e-24 Hematocrit; CRC cis rs739401 0.611 rs7394974 chr11:3038868 C/T cg08508325 chr11:3079039 CARS -0.51 -9.64 -0.47 1.59e-19 Longevity; CRC cis rs763121 0.776 rs5757177 chr22:39007174 A/C cg06022373 chr22:39101656 GTPBP1 0.76 12.14 0.56 2.92e-28 Menopause (age at onset); CRC cis rs6502050 0.835 rs62080004 chr17:80079079 C/T cg25804541 chr17:80189381 SLC16A3 0.31 6.01 0.31 4.93e-9 Life satisfaction; CRC cis rs66573146 0.572 rs67750430 chr4:6957266 T/G cg26116260 chr4:7069785 GRPEL1 -0.58 -5.76 -0.3 1.94e-8 Granulocyte percentage of myeloid white cells; CRC cis rs9494145 0.680 rs9389269 chr6:135427159 T/C cg22676075 chr6:135203613 NA 0.57 7.3 0.37 2.24e-12 Mean platelet volume;Platelet count;Fetal hemoglobin levels in sickle cell anemia;Red blood cell traits; CRC cis rs11148252 0.557 rs9536223 chr13:53233194 A/T cg20354231 chr13:53171401 NA -0.43 -6.86 -0.35 3.51e-11 Lewy body disease; CRC cis rs6500602 0.653 rs4786487 chr16:4440397 C/G cg08645402 chr16:4508243 NA -0.56 -8.94 -0.44 2.89e-17 Schizophrenia; CRC cis rs1218582 0.772 rs6699043 chr1:154913021 T/C cg24250549 chr1:154909240 PMVK 0.64 10.86 0.51 1.06e-23 Prostate cancer; CRC trans rs16957091 0.528 rs72713784 chr15:43115936 A/G cg07673103 chr8:74277181 NA 0.56 6.13 0.32 2.56e-9 MGMT methylation in smokers; CRC cis rs9811920 0.638 rs704581 chr3:99556160 A/T cg07805332 chr3:99536008 MIR548G;C3orf26 0.53 7.99 0.4 2.27e-14 Axial length; CRC cis rs3785574 1.000 rs7223257 chr17:61787684 T/C cg11494091 chr17:61959527 GH2 0.39 6.08 0.32 3.32e-9 Height; CRC cis rs17539620 0.624 rs4566892 chr6:154837346 C/T cg20019720 chr6:154832845 CNKSR3 0.5 8.15 0.41 7.48e-15 Lipoprotein (a) levels; CRC cis rs6570726 0.935 rs12663204 chr6:145818373 G/A cg23711669 chr6:146136114 FBXO30 0.68 12.16 0.56 2.33e-28 Lobe attachment (rater-scored or self-reported); CRC cis rs58688157 0.705 rs12419618 chr11:611531 G/A cg09218773 chr11:619014 MUPCDH -0.42 -6.08 -0.32 3.35e-9 Systemic lupus erythematosus; CRC cis rs9847710 0.708 rs2581811 chr3:53085801 T/C cg18099408 chr3:52552593 STAB1 0.41 6.14 0.32 2.44e-9 Ulcerative colitis; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg17820247 chr12:6579852 VAMP1 0.36 6.6 0.34 1.62e-10 Liver disease severity in Alagille syndrome; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg13260133 chr10:104626808 NA 0.43 6.86 0.35 3.51e-11 Liver disease severity in Alagille syndrome; CRC cis rs4638749 0.677 rs12611470 chr2:108839349 C/T cg25838818 chr2:108905173 SULT1C2 -0.33 -5.61 -0.3 4.35e-8 Blood pressure; CRC trans rs7615952 0.512 rs4234285 chr3:125404477 G/A cg16558177 chr4:4109446 NA -0.62 -8.88 -0.44 4.49e-17 Blood pressure (smoking interaction); CRC cis rs10256972 0.706 rs12701969 chr7:1121849 A/G cg16145915 chr7:1198662 ZFAND2A -0.41 -7.71 -0.39 1.49e-13 Longevity;Endometriosis; CRC trans rs9987353 0.518 rs4841110 chr8:9086023 C/T cg06636001 chr8:8085503 FLJ10661 0.53 8.29 0.42 2.86e-15 Recombination measurement; CRC cis rs9611565 0.512 rs9611672 chr22:42209922 A/G cg06481639 chr22:41940642 POLR3H -0.6 -6.69 -0.35 9.69e-11 Vitiligo; CRC cis rs9341808 0.754 rs9341811 chr6:80982701 G/A cg08355045 chr6:80787529 NA 0.35 5.7 0.3 2.69e-8 Sitting height ratio; CRC cis rs9457247 0.967 rs2769355 chr6:167380493 G/A cg23791538 chr6:167370224 RNASET2 0.39 6.08 0.32 3.37e-9 Crohn's disease; CRC cis rs1707322 1.000 rs785497 chr1:46591903 G/C cg06784218 chr1:46089804 CCDC17 -0.61 -10.54 -0.5 1.37e-22 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs1005277 0.579 rs2474574 chr10:38387295 C/T cg17219203 chr10:38645113 HSD17B7P2 -0.41 -5.76 -0.3 1.9e-8 Extrinsic epigenetic age acceleration; CRC trans rs9388451 0.839 rs1811852 chr6:126071575 G/C cg05039488 chr6:79577232 IRAK1BP1 -0.58 -9.05 -0.45 1.24e-17 Brugada syndrome; CRC cis rs72945132 0.882 rs7114200 chr11:70186099 C/A cg00319359 chr11:70116639 PPFIA1 0.65 6.88 0.35 3.11e-11 Coronary artery disease; CRC cis rs4713118 0.513 rs183244 chr6:28031838 C/A cg02683197 chr6:28174875 NA 0.63 8.49 0.42 7.22e-16 Parkinson's disease; CRC cis rs589448 0.933 rs523398 chr12:69752775 C/T cg14784868 chr12:69753453 YEATS4 0.91 17.35 0.69 2.44e-48 Cerebrospinal fluid biomarker levels; CRC cis rs16852403 0.619 rs10913513 chr1:178135941 A/G cg00404053 chr1:178313656 RASAL2 0.6 7.59 0.39 3.27e-13 Childhood ear infection; CRC cis rs873946 0.564 rs2803991 chr10:134557068 A/G cg18305652 chr10:134549665 INPP5A 0.44 6.31 0.33 9.07e-10 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CRC cis rs4654899 0.865 rs7541923 chr1:21403582 G/C cg02927042 chr1:21476669 EIF4G3 -0.51 -7.76 -0.39 1.05e-13 Superior frontal gyrus grey matter volume; CRC trans rs877282 0.947 rs7923867 chr10:768094 G/A cg22713356 chr15:30763199 NA 1.33 16.07 0.66 2.6e-43 Uric acid levels; CRC trans rs12599106 0.792 rs11648801 chr16:34360980 C/T cg01516881 chr6:292596 DUSP22 -0.56 -8.07 -0.41 1.33e-14 Menopause (age at onset); CRC cis rs1552244 1.000 rs33917318 chr3:10067797 T/C cg16606324 chr3:10149918 C3orf24 0.69 9.36 0.46 1.3e-18 Alzheimer's disease; CRC cis rs910316 0.763 rs175042 chr14:75470833 A/T cg08847533 chr14:75593920 NEK9 -0.85 -14.35 -0.62 1.33e-36 Height; CRC cis rs1953600 1.000 rs2573346 chr10:81918041 G/A cg04850286 chr10:81895943 PLAC9 -0.37 -6.52 -0.34 2.69e-10 Sarcoidosis; CRC cis rs6582630 0.679 rs7301806 chr12:38596667 G/A cg26384229 chr12:38710491 ALG10B 0.43 6.22 0.32 1.51e-9 Drug-induced liver injury (flucloxacillin); CRC cis rs8060686 0.920 rs73591968 chr16:67803063 G/A cg19582491 chr16:67682965 RLTPR -0.57 -6.53 -0.34 2.56e-10 HDL cholesterol;Metabolic syndrome; CRC cis rs1552244 0.816 rs56387520 chr3:10042782 C/T cg08888203 chr3:10149979 C3orf24 0.62 8.3 0.42 2.65e-15 Alzheimer's disease; CRC cis rs1816752 0.776 rs9511268 chr13:25018320 A/G cg02811702 chr13:24901961 NA 0.46 6.31 0.33 9.03e-10 Obesity-related traits; CRC cis rs7107174 1.000 rs10899453 chr11:77997482 A/C cg02023728 chr11:77925099 USP35 0.53 8.16 0.41 7.19e-15 Testicular germ cell tumor; CRC cis rs4713118 0.621 rs9368548 chr6:28034737 A/G cg21251018 chr6:28226885 NKAPL 0.47 6.33 0.33 7.97e-10 Parkinson's disease; CRC cis rs853679 0.517 rs6922063 chr6:28094366 G/A cg21251018 chr6:28226885 NKAPL 0.48 6.33 0.33 8.08e-10 Depression; CRC cis rs643506 0.967 rs2850248 chr11:111644824 C/A cg09085632 chr11:111637200 PPP2R1B 0.5 6.42 0.33 4.64e-10 Breast cancer; CRC trans rs11098499 0.908 rs12504149 chr4:120318577 G/A cg25214090 chr10:38739885 LOC399744 0.65 10.36 0.5 6.04e-22 Corneal astigmatism; CRC cis rs7534824 0.543 rs6577221 chr1:101420406 G/A cg16556008 chr1:101360663 SLC30A7;EXTL2 0.57 5.77 0.3 1.79e-8 Refractive astigmatism; CRC cis rs4665809 0.838 rs6546749 chr2:26306288 T/C cg25036284 chr2:26402008 FAM59B -0.47 -5.88 -0.31 9.99e-9 Gut microbiome composition (summer); CRC cis rs6604026 0.656 rs2811600 chr1:93334138 C/T cg17283838 chr1:93427260 FAM69A -0.42 -5.62 -0.3 4.1e-8 Multiple sclerosis; CRC cis rs3760982 0.585 rs67773424 chr19:44293994 G/A cg11993925 chr19:44307056 LYPD5 0.56 9.92 0.48 1.87e-20 Breast cancer (estrogen-receptor negative);Breast cancer; CRC cis rs9372498 0.536 rs1319987 chr6:118782236 A/G cg18833306 chr6:118973337 C6orf204 0.45 5.82 0.31 1.44e-8 Diastolic blood pressure; CRC cis rs9467711 0.651 rs13200797 chr6:26122957 G/A cg16898833 chr6:26189333 HIST1H4D 0.69 6.06 0.32 3.64e-9 Autism spectrum disorder or schizophrenia; CRC cis rs123509 0.687 rs73075301 chr3:42832650 C/T cg12982090 chr3:42733453 KBTBD5 -0.56 -6.82 -0.35 4.36e-11 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs9858542 0.953 rs9827708 chr3:49649989 C/G cg00383909 chr3:49044727 WDR6 0.5 6.2 0.32 1.72e-9 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg14298966 chr12:49393226 DDN 0.43 6.03 0.32 4.5e-9 Anxiety disorder; CRC cis rs9470366 0.816 rs4331968 chr6:36623243 A/T cg08179530 chr6:36648295 CDKN1A 0.5 5.95 0.31 6.95e-9 QRS duration; CRC trans rs12310399 0.772 rs6538602 chr12:95525641 C/A cg09150239 chr1:204347429 NA 0.43 6.15 0.32 2.27e-9 Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel + carboplatin); CRC trans rs11098499 0.754 rs1980027 chr4:120251577 C/T cg25214090 chr10:38739885 LOC399744 0.53 8.32 0.42 2.41e-15 Corneal astigmatism; CRC cis rs9649213 0.593 rs62478200 chr7:97980045 A/G cg00277769 chr7:97922759 BAIAP2L1 -0.6 -10.31 -0.49 8.94e-22 Prostate cancer (SNP x SNP interaction); CRC cis rs7824557 0.564 rs2572400 chr8:11234367 T/G cg08071915 chr8:12219732 FAM66A 0.32 5.74 0.3 2.13e-8 Retinal vascular caliber; CRC cis rs798554 1.000 rs798536 chr7:2766383 G/A cg13628971 chr7:2884303 GNA12 0.5 6.65 0.34 1.24e-10 Height; CRC cis rs11229555 0.645 rs7926682 chr11:58189495 A/G cg15696309 chr11:58395628 NA -0.82 -10.31 -0.49 8.59e-22 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; CRC cis rs1023500 0.596 rs133369 chr22:42463814 C/T cg04733989 chr22:42467013 NAGA 0.61 9.41 0.46 8.85e-19 Schizophrenia; CRC trans rs6951245 0.572 rs79396168 chr7:1048928 C/T cg13565492 chr6:43139072 SRF -0.86 -6.29 -0.33 1.03e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs9372498 0.505 rs62422247 chr6:118987559 G/T cg07617317 chr6:118971624 C6orf204 0.5 5.91 0.31 8.47e-9 Diastolic blood pressure; CRC cis rs854572 0.600 rs705382 chr7:94955221 C/G cg05342682 chr7:94953680 PON1 -0.51 -8.26 -0.41 3.56e-15 Paraoxonase activity; CRC cis rs758324 0.947 rs6596041 chr5:131198860 C/T cg06307176 chr5:131281290 NA 0.41 5.94 0.31 7.3e-9 Alzheimer's disease in APOE e4- carriers; CRC cis rs9649213 0.613 rs7777415 chr7:97959214 A/T cg21770322 chr7:97807741 LMTK2 0.53 8.59 0.43 3.59e-16 Prostate cancer (SNP x SNP interaction); CRC cis rs1799949 0.965 rs9897425 chr17:41430179 C/G cg05368731 chr17:41323189 NBR1 0.61 9.3 0.46 2.03e-18 Menopause (age at onset); CRC cis rs910316 0.789 rs175457 chr14:75584507 C/T cg03030879 chr14:75389066 RPS6KL1 0.41 6.35 0.33 6.98e-10 Height; CRC cis rs7223966 1.000 rs9909992 chr17:61731931 G/A cg05941027 chr17:61774174 LIMD2 0.36 6.63 0.34 1.41e-10 Hip circumference adjusted for BMI;Body mass index; CRC cis rs2153535 0.541 rs1414352 chr6:8485547 A/C cg21535247 chr6:8435926 SLC35B3 0.5 7.51 0.38 5.54e-13 Motion sickness; CRC cis rs9859260 0.614 rs493661 chr3:195786489 T/A cg12923728 chr3:195709715 SDHAP1 0.48 6.49 0.34 3.12e-10 Mean corpuscular volume; CRC cis rs7901135 0.962 rs4293075 chr10:60561751 A/G cg23799393 chr10:60588674 BICC1 0.39 5.94 0.31 7.18e-9 Morning vs. evening chronotype; CRC cis rs7949030 0.596 rs11231138 chr11:62316195 C/G cg13298116 chr11:62369859 EML3;MTA2 0.62 11.13 0.52 1.22e-24 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; CRC cis rs2760061 0.819 rs964941 chr1:228193857 G/A cg01200585 chr1:228362443 C1orf69 0.39 5.73 0.3 2.22e-8 Diastolic blood pressure; CRC trans rs116095464 0.558 rs2288457 chr5:231270 C/T cg00938859 chr5:1591904 SDHAP3 0.72 7.88 0.4 4.89e-14 Breast cancer; CRC cis rs3026101 0.671 rs12602061 chr17:5302645 T/C cg25236894 chr17:5323110 RPAIN;NUP88 0.42 6.9 0.36 2.74e-11 Body mass index; CRC cis rs9486719 1.000 rs2142652 chr6:96868504 A/C cg06623918 chr6:96969491 KIAA0776 0.81 9.48 0.46 5.18e-19 Migraine;Coronary artery disease; CRC cis rs57994353 0.897 rs72775772 chr9:139356738 C/T cg14119001 chr9:139324193 INPP5E -0.44 -6.23 -0.32 1.46e-9 Eosinophil counts;Cutaneous squamous cell carcinoma; CRC trans rs453301 0.686 rs10217044 chr8:8894752 A/G cg16141378 chr3:129829833 LOC729375 0.41 6.13 0.32 2.45e-9 Joint mobility (Beighton score); CRC cis rs7662987 0.517 rs1154410 chr4:100006645 A/G cg12011299 chr4:100065546 ADH4 0.47 9.02 0.45 1.61e-17 Smoking initiation; CRC cis rs1048238 0.506 rs10927866 chr1:16175317 C/T cg21385522 chr1:16154831 NA 0.6 8.84 0.44 5.91e-17 Systolic blood pressure; CRC cis rs10504229 0.683 rs2101864 chr8:58113226 C/T cg02290350 chr8:58132656 NA -0.6 -8.3 -0.42 2.8e-15 Developmental language disorder (linguistic errors); CRC cis rs425277 0.606 rs262664 chr1:2083537 G/C cg12639453 chr1:2035780 PRKCZ 0.31 5.74 0.3 2.2e-8 Height; CRC cis rs7178572 0.568 rs11857294 chr15:77596725 C/T cg22256960 chr15:77711686 NA -0.65 -9.43 -0.46 7.66e-19 Type 2 diabetes; CRC cis rs11098499 0.909 rs1546502 chr4:120235898 A/G cg24375607 chr4:120327624 NA 0.48 7.29 0.37 2.38e-12 Corneal astigmatism; CRC cis rs9467773 1.000 rs9393732 chr6:26530898 G/A cg09904177 chr6:26538194 HMGN4 0.86 14.9 0.63 9.92e-39 Intelligence (multi-trait analysis); CRC cis rs782590 0.774 rs782630 chr2:55899425 T/C cg18811423 chr2:55921094 PNPT1 0.85 16.24 0.67 6e-44 Metabolic syndrome; CRC cis rs490234 0.676 rs1129 chr9:128199873 A/G cg14078157 chr9:128172775 NA 0.39 6.44 0.33 4.31e-10 Mean arterial pressure; CRC cis rs425277 0.606 rs262653 chr1:2090095 T/G cg04315214 chr1:2043799 PRKCZ -0.36 -6.2 -0.32 1.7e-9 Height; CRC cis rs473651 0.935 rs540636 chr2:239358341 T/C cg18131467 chr2:239335373 ASB1 1.03 23.18 0.79 3.67e-71 Multiple system atrophy; CRC cis rs644799 0.710 rs564480 chr11:95561741 C/T cg25622487 chr11:95524042 FAM76B;CEP57 0.8 13.67 0.6 5.48e-34 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs1050631 0.564 rs1785904 chr18:33713132 T/C cg25426722 chr18:33708991 SLC39A6;ELP2 0.37 5.73 0.3 2.27e-8 Esophageal squamous cell cancer (length of survival); CRC cis rs7216064 0.628 rs62084702 chr17:66043157 C/T cg12091567 chr17:66097778 LOC651250 0.92 13.95 0.61 4.4e-35 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CRC cis rs4713118 0.662 rs9468274 chr6:28026077 G/T cg15845792 chr6:28175446 NA 0.96 13.94 0.61 5.17e-35 Parkinson's disease; CRC cis rs9487051 0.735 rs351745 chr6:109529169 C/T cg21918786 chr6:109611834 NA 0.37 6.43 0.33 4.58e-10 Reticulocyte fraction of red cells; CRC cis rs7725052 0.609 rs7725387 chr5:40459749 G/C cg09067459 chr5:40385259 NA 0.39 6.43 0.33 4.42e-10 Pediatric autoimmune diseases; CRC cis rs12477438 0.520 rs6542865 chr2:99764521 C/T cg26064155 chr2:99771622 LIPT1;TSGA10 0.87 15.71 0.65 6.73e-42 Chronic sinus infection; CRC trans rs9650657 0.644 rs3808603 chr8:10698218 T/C cg06636001 chr8:8085503 FLJ10661 -0.4 -6.08 -0.32 3.34e-9 Neuroticism; CRC cis rs9322193 0.884 rs10872646 chr6:150067675 A/G cg07701084 chr6:150067640 NUP43 0.59 8.71 0.43 1.48e-16 Lung cancer; CRC cis rs2692947 0.683 rs62153700 chr2:96581338 C/T cg23100626 chr2:96804247 ASTL 0.29 7.03 0.36 1.19e-11 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; CRC cis rs6952808 0.692 rs56727870 chr7:2029940 T/C cg00106254 chr7:1943704 MAD1L1 -0.56 -8.2 -0.41 5.62e-15 Bipolar disorder and schizophrenia; CRC cis rs11166629 1.000 rs3739423 chr8:135614705 A/G cg27224718 chr8:135614730 ZFAT 0.53 7.8 0.4 8.33e-14 Smoking quantity; CRC cis rs7020830 0.861 rs13289001 chr9:37311592 A/G cg14294708 chr9:37120828 ZCCHC7 1.18 26.89 0.83 4.7e-85 Schizophrenia; CRC trans rs208520 1.000 rs208527 chr6:66957209 A/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.89 -11.02 -0.52 2.96e-24 Exhaled nitric oxide output; CRC trans rs10411161 0.702 rs10402630 chr19:52384570 G/A cg22319618 chr22:45562946 NUP50 -0.69 -7.57 -0.39 3.9e-13 Breast cancer; CRC cis rs896854 0.967 rs10956933 chr8:95967688 C/G cg13393036 chr8:95962371 TP53INP1 -0.55 -9.29 -0.46 2.18e-18 Type 2 diabetes; CRC cis rs4423214 0.840 rs1790344 chr11:71176897 A/G cg05163923 chr11:71159392 DHCR7 -0.64 -7.64 -0.39 2.32e-13 Vitamin D levels; CRC cis rs875971 0.660 rs28698552 chr7:66005018 A/G cg18876405 chr7:65276391 NA 0.61 10.95 0.52 5.42e-24 Aortic root size; CRC cis rs9549260 0.709 rs9549240 chr13:41186644 T/G cg21288729 chr13:41239152 FOXO1 0.42 6.63 0.34 1.4e-10 Red blood cell count; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg07177681 chr21:33105032 SFRS15 0.42 6.09 0.32 3.11e-9 Response to antipsychotic treatment; CRC trans rs7267979 0.966 rs6037103 chr20:25369095 A/G cg17903999 chr18:56338584 MALT1 0.4 6.69 0.35 9.66e-11 Liver enzyme levels (alkaline phosphatase); CRC trans rs12660387 1.000 rs10498824 chr6:65259197 T/C cg13393512 chr9:135749454 C9orf98 0.53 6.13 0.32 2.49e-9 Schizophrenia; CRC trans rs7267979 0.903 rs2474766 chr20:25246153 A/G cg17903999 chr18:56338584 MALT1 -0.4 -6.38 -0.33 6.05e-10 Liver enzyme levels (alkaline phosphatase); CRC cis rs847577 0.630 rs13221758 chr7:97719806 A/C cg24562669 chr7:97807699 LMTK2 0.78 17.53 0.7 4.54e-49 Breast cancer; CRC cis rs9733 0.818 rs12403609 chr1:150676485 T/C cg17724175 chr1:150552817 MCL1 -0.47 -7.39 -0.38 1.19e-12 Tonsillectomy; CRC cis rs4713118 0.869 rs7773070 chr6:27728827 T/C cg15786705 chr6:28176104 NA 0.55 7.6 0.39 3.15e-13 Parkinson's disease; CRC cis rs73206853 0.843 rs12320025 chr12:110742991 A/G cg12870014 chr12:110450643 ANKRD13A 0.67 8.39 0.42 1.41e-15 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC cis rs11252926 0.537 rs4881255 chr10:453638 T/C cg18196295 chr10:418757 DIP2C 0.48 7.43 0.38 9.7e-13 Psychosis in Alzheimer's disease; CRC cis rs10256972 0.567 rs7782651 chr7:1159895 T/G cg07092213 chr7:1199455 ZFAND2A -0.44 -6.1 -0.32 2.97e-9 Longevity;Endometriosis; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg20332865 chr2:206177247 PARD3B 0.41 6.45 0.34 3.97e-10 Liver disease severity in Alagille syndrome; CRC cis rs11105298 0.891 rs3741899 chr12:89933931 G/A cg08166232 chr12:89918718 WDR51B;GALNT4 -0.59 -7.28 -0.37 2.51e-12 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; CRC cis rs7224685 1.000 rs7224685 chr17:4014384 G/T cg09597638 chr17:3907349 NA 0.46 7.07 0.36 9.35e-12 Type 2 diabetes; CRC cis rs10905065 0.804 rs2380202 chr10:5823397 C/T cg11519256 chr10:5708881 ASB13 -0.44 -6.33 -0.33 8.11e-10 Menopause (age at onset); CRC trans rs2727020 0.729 rs2299650 chr11:49174007 A/C cg11707556 chr5:10655725 ANKRD33B -0.36 -6.57 -0.34 1.97e-10 Coronary artery disease; CRC cis rs2692947 0.800 rs61409777 chr2:96581373 C/A cg23100626 chr2:96804247 ASTL 0.27 7.09 0.36 8.15e-12 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; CRC cis rs2463822 1.000 rs115395195 chr11:62100353 G/A cg06239285 chr11:62104954 ASRGL1 -1.03 -10.44 -0.5 3.16e-22 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs78456975 1.000 rs11899027 chr2:1560414 G/C cg12573674 chr2:1569213 NA -0.77 -8.05 -0.41 1.51e-14 Placebo response in major depressive disorder (% change in symptom score); CRC cis rs10256972 0.521 rs10280960 chr7:1103697 A/G cg18765753 chr7:1198926 ZFAND2A -0.33 -5.99 -0.31 5.59e-9 Longevity;Endometriosis; CRC trans rs8002861 0.664 rs4942247 chr13:44405107 A/G cg12856521 chr11:46389249 DGKZ 0.43 6.85 0.35 3.69e-11 Leprosy; CRC cis rs4664304 0.658 rs2667015 chr2:160868586 T/C cg03641300 chr2:160917029 PLA2R1 -0.39 -5.65 -0.3 3.46e-8 Crohn's disease;Inflammatory bowel disease; CRC cis rs2898857 0.524 rs2960172 chr17:47379581 G/A cg08112188 chr17:47440006 ZNF652 0.42 5.62 0.3 4.04e-8 Cancer; CRC cis rs4727027 0.899 rs4727025 chr7:148862863 A/G cg12479418 chr7:148823350 ZNF425;ZNF398 0.42 5.75 0.3 2e-8 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC cis rs924607 0.966 rs1621827 chr5:635074 A/G cg04476341 chr5:669733 TPPP 0.42 6.88 0.35 3.1e-11 Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia; CRC cis rs9811920 0.638 rs793503 chr3:99588070 A/G cg07805332 chr3:99536008 MIR548G;C3orf26 -0.54 -8.15 -0.41 7.92e-15 Axial length; CRC trans rs7267979 1.000 rs6050626 chr20:25428261 T/C cg17903999 chr18:56338584 MALT1 -0.42 -6.98 -0.36 1.6e-11 Liver enzyme levels (alkaline phosphatase); CRC cis rs524281 0.731 rs11227439 chr11:66025679 G/A cg14036092 chr11:66035641 RAB1B -0.55 -6.02 -0.32 4.64e-9 Electroencephalogram traits; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg06140764 chr6:30539234 ABCF1 0.48 6.81 0.35 4.68e-11 Anxiety disorder; CRC cis rs77861329 0.748 rs747343 chr3:52109407 T/C cg08692210 chr3:52188851 WDR51A 0.55 6.26 0.33 1.17e-9 Macrophage inflammatory protein 1b levels; CRC cis rs13418455 0.619 rs1401263 chr2:181188035 G/T cg23363182 chr2:181467187 NA 0.39 5.62 0.3 4.14e-8 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg26933359 chr14:20937370 PNP 0.44 6.42 0.33 4.83e-10 Intelligence (multi-trait analysis); CRC cis rs79387448 0.505 rs17027327 chr2:103122513 C/A cg00507830 chr2:103233733 NA 0.5 5.63 0.3 3.86e-8 Gut microbiota (bacterial taxa); CRC cis rs1552244 1.000 rs6793396 chr3:10110927 T/C cg16606324 chr3:10149918 C3orf24 0.72 9.82 0.48 3.92e-20 Alzheimer's disease; CRC cis rs1552244 1.000 rs7619340 chr3:10108178 C/T cg13047869 chr3:10149882 C3orf24 0.59 7.95 0.4 2.94e-14 Alzheimer's disease; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg19733847 chr19:8571072 NA 0.43 6.35 0.33 7.27e-10 Intelligence (multi-trait analysis); CRC cis rs17253792 0.822 rs17683614 chr14:56041058 G/A cg01858014 chr14:56050164 KTN1 -0.89 -6.88 -0.35 2.95e-11 Putamen volume; CRC cis rs2075371 0.966 rs2544223 chr7:133995787 A/G cg20476274 chr7:133979776 SLC35B4 0.82 14.9 0.63 9.84e-39 Mean platelet volume; CRC cis rs950776 0.518 rs12907169 chr15:78825498 G/C cg06917634 chr15:78832804 PSMA4 0.66 10.42 0.5 3.55e-22 Sudden cardiac arrest; CRC cis rs6762 0.748 rs1130663 chr11:837582 G/A cg03116740 chr11:841335 TSPAN4;POLR2L -0.42 -7.21 -0.37 3.96e-12 Mean platelet volume; CRC cis rs6502050 0.769 rs9898292 chr17:80100345 A/T cg19223190 chr17:80058835 NA 0.4 6.36 0.33 6.88e-10 Life satisfaction; CRC cis rs9341808 0.727 rs9361599 chr6:81025242 C/G cg08355045 chr6:80787529 NA 0.38 6.28 0.33 1.07e-9 Sitting height ratio; CRC cis rs1799949 0.929 rs799905 chr17:41277187 G/C cg19454999 chr17:41278357 BRCA1;NBR2 0.39 5.95 0.31 6.97e-9 Menopause (age at onset); CRC cis rs911119 1.000 rs1064039 chr20:23618427 C/T cg16589663 chr20:23618590 CST3 0.62 8.01 0.4 2.01e-14 Chronic kidney disease; CRC cis rs3815700 1.000 rs10406750 chr19:33097144 C/T cg02997394 chr19:33096574 ANKRD27 0.75 8.73 0.43 1.33e-16 Eosinophilic esophagitis; CRC cis rs6964587 1.000 rs2282972 chr7:91666369 C/T cg17063962 chr7:91808500 NA 0.81 14.18 0.62 5.98e-36 Breast cancer; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg11530914 chr16:67281528 FHOD1;SLC9A5 0.52 7.5 0.38 5.96e-13 Response to antipsychotic treatment; CRC cis rs2836633 0.929 rs11701577 chr21:40028906 C/T cg05519781 chr21:40033154 ERG 0.68 13.43 0.6 4.32e-33 Coronary artery disease; CRC cis rs13217239 0.646 rs12201393 chr6:26975690 C/A cg12292205 chr6:26970375 C6orf41 0.56 9.32 0.46 1.78e-18 Schizophrenia; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg13085065 chr19:41769941 HNRNPUL1 0.5 6.37 0.33 6.43e-10 Thyroid stimulating hormone; CRC cis rs950169 0.920 rs12915390 chr15:84792069 T/C cg11189052 chr15:85197271 WDR73 0.61 9.03 0.45 1.46e-17 Schizophrenia; CRC cis rs7914558 1.000 rs7911789 chr10:104756374 T/C cg04362960 chr10:104952993 NT5C2 0.61 9.29 0.46 2.14e-18 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs9911578 1.000 rs437732 chr17:56675861 A/C cg12560992 chr17:57184187 TRIM37 0.9 16.5 0.67 5.49e-45 Intelligence (multi-trait analysis); CRC cis rs11792861 0.926 rs11787878 chr9:111866749 C/T cg05043794 chr9:111880884 C9orf5 -0.36 -6.55 -0.34 2.2e-10 Menarche (age at onset); CRC cis rs7264396 0.836 rs6088880 chr20:34165582 G/C cg04508476 chr20:34239394 CPNE1;RBM12 0.44 7.28 0.37 2.52e-12 Total cholesterol levels; CRC cis rs5750830 0.649 rs4384886 chr22:39793766 C/T cg05872129 chr22:39784769 NA -0.64 -12.79 -0.58 1.08e-30 Intelligence (multi-trait analysis); CRC cis rs7666738 0.830 rs7661264 chr4:98961574 G/A cg05340658 chr4:99064831 C4orf37 0.61 9.45 0.46 6.55e-19 Colonoscopy-negative controls vs population controls; CRC cis rs17345786 1.000 rs58907984 chr3:101305170 T/G cg12386194 chr3:101231763 SENP7 0.56 7.33 0.37 1.8e-12 Colonoscopy-negative controls vs population controls; CRC cis rs1448094 0.556 rs17345522 chr12:86169929 T/C cg00310523 chr12:86230176 RASSF9 0.42 6.83 0.35 4.13e-11 Major depressive disorder; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg09670790 chr13:76056027 TBC1D4 0.44 6.12 0.32 2.65e-9 Anxiety disorder; CRC cis rs6582630 0.502 rs2204008 chr12:38439203 C/T cg26384229 chr12:38710491 ALG10B 0.67 9.19 0.45 4.47e-18 Drug-induced liver injury (flucloxacillin); CRC cis rs35306767 0.855 rs2050944 chr10:918910 T/C cg20503657 chr10:835505 NA 0.97 12.26 0.56 1.03e-28 Eosinophil percentage of granulocytes; CRC cis rs4665809 0.941 rs2289021 chr2:26362515 A/C cg22920501 chr2:26401640 FAM59B 0.44 5.69 0.3 2.83e-8 Gut microbiome composition (summer); CRC cis rs2075371 0.897 rs1646702 chr7:134000177 C/G cg02659138 chr7:134003124 SLC35B4 0.42 7.36 0.38 1.49e-12 Mean platelet volume; CRC cis rs3020333 0.875 rs2982572 chr6:152010561 C/T cg22157087 chr6:152012887 ESR1 0.52 7.81 0.4 7.96e-14 Total body bone mineral density; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg16917406 chr15:85114159 UBE2QP1 0.45 6.37 0.33 6.33e-10 Response to antipsychotic treatment; CRC cis rs28386778 0.897 rs894406 chr17:61901657 A/G cg06601766 chr17:61851465 DDX42;CCDC47 0.44 5.96 0.31 6.33e-9 Prudent dietary pattern; CRC cis rs4964805 0.641 rs11111755 chr12:104159667 G/A cg02344784 chr12:104178138 NT5DC3 0.49 7.66 0.39 2.17e-13 Attention deficit hyperactivity disorder; CRC trans rs7267979 1.000 rs4815418 chr20:25382211 T/G cg17903999 chr18:56338584 MALT1 0.42 7.02 0.36 1.25e-11 Liver enzyme levels (alkaline phosphatase); CRC cis rs6121246 0.567 rs6120815 chr20:30184866 T/C cg18721089 chr20:30220636 NA -0.52 -7.93 -0.4 3.54e-14 Mean corpuscular hemoglobin; CRC cis rs7044106 0.718 rs1960421 chr9:123394894 C/G cg09419670 chr9:123605666 PSMD5;LOC253039 0.69 10.64 0.51 6.45e-23 Hip circumference adjusted for BMI; CRC cis rs62064224 0.714 rs8074594 chr17:30632998 G/A cg12855166 chr17:30846586 MYO1D -0.39 -6.59 -0.34 1.8e-10 Schizophrenia; CRC cis rs8072100 0.754 rs8081717 chr17:45653921 T/A cg08085267 chr17:45401833 C17orf57 0.66 10.86 0.51 1.07e-23 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs4132509 0.649 rs12038981 chr1:243866855 G/A cg21452805 chr1:244014465 NA 0.58 7.28 0.37 2.55e-12 RR interval (heart rate); CRC cis rs35306767 0.715 rs17221463 chr10:1038040 T/C cg26597838 chr10:835615 NA 0.95 11.25 0.53 4.64e-25 Eosinophil percentage of granulocytes; CRC cis rs853679 0.517 rs9295761 chr6:28147987 A/G cg21251018 chr6:28226885 NKAPL 0.48 6.18 0.32 1.93e-9 Depression; CRC cis rs4713118 0.629 rs172165 chr6:28020814 T/G cg03623178 chr6:28175578 NA 0.88 12.69 0.57 2.62e-30 Parkinson's disease; CRC cis rs6076065 0.723 rs2424548 chr20:23394456 A/C cg11657817 chr20:23433608 CST11 0.44 6.29 0.33 9.83e-10 Facial morphology (factor 15, philtrum width); CRC cis rs10504229 0.728 rs17804774 chr8:58155950 G/T cg02725872 chr8:58115012 NA -0.59 -9.17 -0.45 5.24e-18 Developmental language disorder (linguistic errors); CRC cis rs11203032 0.831 rs2863216 chr10:90941937 C/T cg16672925 chr10:90967113 CH25H 0.44 5.7 0.3 2.6e-8 Heart failure; CRC trans rs4843747 0.708 rs11866437 chr16:88072279 A/G cg26811252 chr16:29126840 RRN3P2 -0.64 -8.98 -0.44 2.1e-17 Menopause (age at onset); CRC cis rs9300255 0.663 rs7953929 chr12:123758235 C/G cg00376283 chr12:123451042 ABCB9 0.5 6.12 0.32 2.6e-9 Neutrophil percentage of white cells; CRC cis rs6570726 0.818 rs398812 chr6:145817271 T/C cg05347473 chr6:146136440 FBXO30 0.37 5.86 0.31 1.11e-8 Lobe attachment (rater-scored or self-reported); CRC cis rs8141797 0.901 rs2330722 chr22:24491488 C/G cg20894457 chr22:24584366 SUSD2 -0.66 -6.86 -0.35 3.51e-11 Amyotrophic lateral sclerosis;Coronary artery disease; CRC cis rs7949030 0.626 rs11231154 chr11:62362293 A/G cg13298116 chr11:62369859 EML3;MTA2 0.61 10.71 0.51 3.81e-23 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; CRC trans rs3018066 0.738 rs12639678 chr4:106952765 A/T cg02609279 chr2:182325952 ITGA4 -0.44 -6.05 -0.32 3.91e-9 Cancer; CRC cis rs6582630 0.555 rs12372536 chr12:38400864 C/G cg26384229 chr12:38710491 ALG10B 0.7 9.81 0.48 4.41e-20 Drug-induced liver injury (flucloxacillin); CRC cis rs3771570 1.000 rs62193221 chr2:242354632 T/C cg21155796 chr2:242212141 HDLBP 0.66 7.15 0.37 5.74e-12 Prostate cancer; CRC trans rs3733585 0.781 rs13103879 chr4:9972879 T/C cg26043149 chr18:55253948 FECH -0.53 -8.31 -0.42 2.56e-15 Cleft plate (environmental tobacco smoke interaction); CRC cis rs7086627 0.515 rs2125040 chr10:82208422 G/C cg09626299 chr10:82213104 TSPAN14 -0.37 -6.23 -0.33 1.39e-9 Post bronchodilator FEV1; CRC trans rs208520 0.661 rs207111 chr6:66792513 C/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.08 -15.36 -0.65 1.56e-40 Exhaled nitric oxide output; CRC cis rs4363385 0.818 rs12085426 chr1:153003074 C/A cg25856811 chr1:152973957 SPRR3 -0.26 -7.28 -0.37 2.52e-12 Inflammatory skin disease; CRC cis rs2976388 0.609 rs2585145 chr8:143799457 G/A cg12516270 chr8:143859308 LYNX1 0.43 7.43 0.38 9.19e-13 Urinary tract infection frequency; CRC cis rs10927875 0.632 rs904911 chr1:16126932 C/T cg21385522 chr1:16154831 NA -1.06 -17.31 -0.69 3.46e-48 Dilated cardiomyopathy; CRC cis rs6502050 0.805 rs56020943 chr17:80105248 C/A cg19223190 chr17:80058835 NA 0.4 6.36 0.33 6.88e-10 Life satisfaction; CRC cis rs1816752 0.712 rs6490932 chr13:25017451 A/G cg02811702 chr13:24901961 NA 0.47 6.49 0.34 3.07e-10 Obesity-related traits; CRC cis rs863345 0.604 rs1342952 chr1:158464430 C/A cg12129480 chr1:158549410 OR10X1 -0.3 -6.32 -0.33 8.42e-10 Pneumococcal bacteremia; CRC cis rs2976388 0.609 rs1560986 chr8:143789775 T/C cg12516270 chr8:143859308 LYNX1 0.42 7.54 0.38 4.55e-13 Urinary tract infection frequency; CRC cis rs6762 0.748 rs1130663 chr11:837582 G/A cg11173246 chr11:841376 TSPAN4;POLR2L -0.34 -5.75 -0.3 2.01e-8 Mean platelet volume; CRC cis rs9916302 0.706 rs8075737 chr17:37727316 C/T cg07936489 chr17:37558343 FBXL20 0.92 12.43 0.57 2.34e-29 Glomerular filtration rate (creatinine); CRC trans rs13046373 0.905 rs4816372 chr21:32077414 A/T cg02641420 chr17:65688720 PITPNC1 -0.37 -6.36 -0.33 6.87e-10 HDL cholesterol; CRC cis rs6426558 0.502 rs2813965 chr1:227445733 A/G cg10327440 chr1:227177885 CDC42BPA 0.44 6.59 0.34 1.76e-10 Neutrophil percentage of white cells; CRC trans rs12699921 0.573 rs2723562 chr7:17846620 C/G cg15753394 chr6:17282781 RBM24 -0.36 -6.03 -0.32 4.44e-9 Fibrinogen levels; CRC cis rs13191362 1.000 rs13207671 chr6:162979056 A/G cg21926612 chr6:163149169 PACRG;PARK2 0.82 11.49 0.54 6.51e-26 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs863345 0.584 rs6657638 chr1:158497184 C/G cg12129480 chr1:158549410 OR10X1 -0.29 -5.95 -0.31 6.94e-9 Pneumococcal bacteremia; CRC trans rs853679 0.760 rs967005 chr6:28210688 C/T cg06606381 chr12:133084897 FBRSL1 -0.65 -6.7 -0.35 8.99e-11 Depression; CRC cis rs2952156 0.920 rs2517958 chr17:37838751 G/A cg11212589 chr17:38028394 ZPBP2 0.34 6.02 0.32 4.65e-9 Asthma; CRC cis rs4625783 0.583 rs11077974 chr17:80095193 A/G cg11859384 chr17:80120422 CCDC57 -0.37 -5.85 -0.31 1.16e-8 Blood metabolite levels; CRC cis rs1707322 0.752 rs8179296 chr1:46143791 G/A cg03146154 chr1:46216737 IPP 0.67 9.75 0.47 6.98e-20 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs7769051 0.522 rs60631157 chr6:133094817 G/A cg07930552 chr6:133119739 C6orf192 0.77 7.52 0.38 5.15e-13 Type 2 diabetes nephropathy; CRC cis rs1552244 0.882 rs35056669 chr3:10014171 C/T cg10729496 chr3:10149963 C3orf24 0.49 6.38 0.33 5.96e-10 Alzheimer's disease; CRC cis rs9322193 0.962 rs9688412 chr6:150124283 A/G cg00933542 chr6:150070202 PCMT1 -0.29 -5.83 -0.31 1.32e-8 Lung cancer; CRC cis rs10927875 0.619 rs1806991 chr1:16129441 T/C cg21385522 chr1:16154831 NA -0.75 -11.89 -0.55 2.27e-27 Dilated cardiomyopathy; CRC cis rs9660992 0.573 rs12140703 chr1:205182865 G/C cg00857998 chr1:205179979 DSTYK 0.44 5.86 0.31 1.1e-8 Mean corpuscular volume;Mean platelet volume; CRC cis rs1448094 0.512 rs12314318 chr12:86249238 T/C cg25456477 chr12:86230367 RASSF9 0.34 5.99 0.31 5.54e-9 Major depressive disorder; CRC cis rs2050392 0.861 rs1042058 chr10:30728101 T/C cg25182066 chr10:30743637 MAP3K8 -0.41 -5.96 -0.31 6.64e-9 Inflammatory bowel disease; CRC cis rs2236521 0.659 rs72487383 chr20:60889313 A/C cg09594475 chr20:60884601 LAMA5 0.37 6.09 0.32 3.1e-9 Pelvic organ prolapse; CRC cis rs8060686 0.623 rs58388686 chr16:68075439 A/G cg26727032 chr16:67993705 SLC12A4 -0.65 -9.8 -0.48 4.59e-20 HDL cholesterol;Metabolic syndrome; CRC cis rs9487051 1.000 rs6568569 chr6:109613196 C/A cg21918786 chr6:109611834 NA -0.38 -6.59 -0.34 1.73e-10 Reticulocyte fraction of red cells; CRC cis rs6500602 0.592 rs4785966 chr16:4518754 C/T cg08645402 chr16:4508243 NA -0.53 -8.33 -0.42 2.26e-15 Schizophrenia; CRC cis rs9322193 0.923 rs9689599 chr6:149953109 A/C cg07701084 chr6:150067640 NUP43 0.55 8.04 0.41 1.58e-14 Lung cancer; CRC cis rs34172651 0.517 rs12920774 chr16:24830750 T/C cg00339695 chr16:24857497 SLC5A11 0.38 7.39 0.38 1.22e-12 Intelligence (multi-trait analysis); CRC trans rs8012941 0.593 rs4902190 chr14:63314591 A/G cg17602776 chr5:178977377 RUFY1 0.4 6.11 0.32 2.76e-9 Major depressive disorder; CRC cis rs6728302 0.557 rs73002000 chr2:233254052 C/T cg14418609 chr2:233286870 NA -0.69 -5.86 -0.31 1.14e-8 Height; CRC cis rs10905065 1.000 rs7913067 chr10:5787305 C/T cg11519256 chr10:5708881 ASB13 0.49 7.13 0.37 6.33e-12 Menopause (age at onset); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg04848196 chr16:75657359 ADAT1 0.44 6.11 0.32 2.84e-9 Response to antipsychotic treatment; CRC cis rs17401966 0.931 rs34225619 chr1:10371987 C/T cg19773385 chr1:10388646 KIF1B -0.57 -7.94 -0.4 3.3e-14 Hepatocellular carcinoma; CRC cis rs478304 0.934 rs517115 chr11:65526988 C/T cg27068330 chr11:65405492 SIPA1 0.48 7.0 0.36 1.45e-11 Acne (severe); CRC cis rs57590327 0.716 rs56106807 chr3:81765270 A/G cg07356753 chr3:81810745 GBE1 -0.63 -7.8 -0.4 8.12e-14 Extraversion; CRC trans rs62295889 0.602 rs73096518 chr4:12536943 T/G cg03490839 chr16:73082051 ZFHX3 0.57 5.97 0.31 6.26e-9 Obesity-related traits; CRC cis rs10256972 0.706 rs12701969 chr7:1121849 A/G cg18765753 chr7:1198926 ZFAND2A -0.35 -5.72 -0.3 2.4e-8 Longevity;Endometriosis; CRC cis rs936229 0.749 rs6495126 chr15:75175026 C/T cg14664628 chr15:75095509 CSK 0.86 14.58 0.63 1.72e-37 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); CRC cis rs12357919 0.542 rs3740471 chr10:105363289 T/C cg00126946 chr10:105363258 SH3PXD2A 0.52 6.48 0.34 3.38e-10 White matter hyperintensity burden; CRC cis rs4474465 0.850 rs10793324 chr11:78251485 C/T cg02023728 chr11:77925099 USP35 0.37 6.21 0.32 1.64e-9 Alzheimer's disease (survival time); CRC cis rs1862618 0.525 rs2662019 chr5:56263104 A/G cg24531977 chr5:56204891 C5orf35 0.8 11.44 0.53 9.38e-26 Initial pursuit acceleration; CRC cis rs6912958 0.781 rs9450738 chr6:88267314 A/G cg08069147 chr6:88032118 GJB7;C6orf162 -0.56 -8.36 -0.42 1.74e-15 Monocyte percentage of white cells; CRC trans rs66759488 0.739 rs10851451 chr15:47608991 A/G cg27112062 chr3:48456733 PLXNB1 -0.45 -6.38 -0.33 6.04e-10 Lung cancer; CRC trans rs916888 0.773 rs199448 chr17:44809001 A/G cg22433210 chr17:43662623 NA 0.97 10.23 0.49 1.66e-21 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs4481887 1.000 rs4474293 chr1:248470438 T/C cg13385794 chr1:248469461 NA 0.38 6.72 0.35 7.94e-11 Common traits (Other); CRC trans rs6550704 0.687 rs9865314 chr3:22634337 A/G cg09712606 chr19:50169182 IRF3;BCL2L12 -0.41 -5.98 -0.31 5.89e-9 Daytime sleep phenotypes; CRC cis rs75920871 0.545 rs7939934 chr11:116861268 A/T cg20608306 chr11:116969690 SIK3 -0.32 -5.82 -0.31 1.41e-8 Subjective well-being; CRC cis rs7258465 1.000 rs10413237 chr19:18548249 A/C cg06953865 chr19:18549723 ISYNA1 -0.38 -5.66 -0.3 3.28e-8 Breast cancer; CRC cis rs6089584 0.850 rs881993 chr20:60623862 A/G cg23463467 chr20:60627584 TAF4 0.38 6.55 0.34 2.19e-10 Body mass index; CRC cis rs826838 0.967 rs980572 chr12:39127673 A/C cg26384229 chr12:38710491 ALG10B 0.65 9.66 0.47 1.37e-19 Heart rate; CRC cis rs6964587 0.900 rs62467794 chr7:91850578 C/T cg01689657 chr7:91764605 CYP51A1 0.36 5.81 0.3 1.51e-8 Breast cancer; CRC trans rs6534347 0.788 rs56267605 chr4:123363109 A/C cg21129976 chr7:100421502 EPHB4 0.39 6.0 0.31 5.35e-9 Type 1 diabetes; CRC cis rs13108904 0.967 rs11730939 chr4:1285560 G/A cg16405210 chr4:1374714 KIAA1530 -0.44 -6.0 -0.31 5.22e-9 Obesity-related traits; CRC cis rs62408225 1.000 rs11752685 chr6:90966415 A/C cg06866423 chr6:90926672 BACH2 0.49 8.16 0.41 7.32e-15 Eosinophil counts;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC trans rs1997103 1.000 rs9649857 chr7:55411777 C/T cg20935933 chr6:143382018 AIG1 0.51 6.63 0.34 1.35e-10 QRS interval (sulfonylurea treatment interaction); CRC trans rs10875746 0.807 rs12297004 chr12:48453820 A/G cg08231274 chr14:57735852 MUDENG;EXOC5 -0.58 -6.05 -0.32 3.98e-9 Longevity (90 years and older); CRC cis rs7078219 0.714 rs11190139 chr10:101288099 C/G cg10506844 chr10:101281203 NA -0.3 -5.64 -0.3 3.63e-8 Dental caries; CRC cis rs10791323 0.604 rs2723607 chr11:133711018 C/G cg03690763 chr11:133734501 NA -0.35 -5.86 -0.31 1.13e-8 Childhood ear infection; CRC trans rs12432203 1.000 rs3935981 chr14:51730283 T/C cg14592830 chr9:122318704 NA 0.59 6.12 0.32 2.62e-9 Cancer; CRC trans rs637571 0.522 rs1786175 chr11:65754808 G/A cg17712092 chr4:129076599 LARP1B 0.7 11.75 0.54 7.42e-27 Eosinophil percentage of white cells; CRC cis rs6499255 0.762 rs12325186 chr16:69658807 A/T cg15192750 chr16:69999425 NA 0.62 7.85 0.4 5.93e-14 IgE levels; CRC cis rs7618501 0.932 rs4855850 chr3:49761571 G/A cg24308560 chr3:49941425 MST1R 0.45 7.16 0.37 5.47e-12 Intelligence (multi-trait analysis); CRC trans rs2303319 0.504 rs62189041 chr2:162599506 T/C cg22922770 chr7:98923339 ARPC1A -0.67 -5.98 -0.31 5.68e-9 Cognitive function; CRC cis rs28386778 1.000 rs2665851 chr17:61957023 T/C cg22520471 chr17:61851767 DDX42;CCDC47 0.73 11.29 0.53 3.26e-25 Prudent dietary pattern; CRC cis rs57221529 0.655 rs11948381 chr5:568413 A/T cg16447950 chr5:562315 NA -0.86 -13.15 -0.59 5.1e-32 Lung disease severity in cystic fibrosis; CRC cis rs736801 0.569 rs11748193 chr5:131725329 A/T cg21138405 chr5:131827807 IRF1 -0.34 -5.88 -0.31 1e-8 Breast cancer;Mosquito bite size; CRC cis rs11758351 0.866 rs2022448 chr6:26207928 C/T cg22723502 chr6:26240528 HIST1H4F -0.34 -6.24 -0.33 1.35e-9 Gout;Renal underexcretion gout; CRC cis rs1552244 0.935 rs35586456 chr3:10116938 A/G cg08888203 chr3:10149979 C3orf24 0.7 10.01 0.48 8.99e-21 Alzheimer's disease; CRC cis rs1005224 0.853 rs61980778 chr14:76151532 C/T cg25116370 chr14:76127843 TTLL5;C14orf1 0.45 7.0 0.36 1.44e-11 Large artery stroke; CRC cis rs208520 0.609 rs208436 chr6:66897470 G/A cg07460842 chr6:66804631 NA -0.67 -9.35 -0.46 1.4e-18 Exhaled nitric oxide output; CRC cis rs2075371 0.966 rs2544225 chr7:133995838 A/C cg02659138 chr7:134003124 SLC35B4 0.4 6.91 0.36 2.47e-11 Mean platelet volume; CRC cis rs1552244 1.000 rs66838678 chr3:10150350 G/A cg08888203 chr3:10149979 C3orf24 0.71 9.52 0.46 3.79e-19 Alzheimer's disease; CRC cis rs769267 0.965 rs6511026 chr19:19391402 C/T cg02546618 chr19:19431379 KIAA0892;SF4 0.46 6.3 0.33 9.51e-10 Tonsillectomy; CRC cis rs7666738 0.830 rs11940273 chr4:98979965 T/A cg17366294 chr4:99064904 C4orf37 0.44 7.45 0.38 8.44e-13 Colonoscopy-negative controls vs population controls; CRC cis rs4713118 0.513 rs149878 chr6:27878738 T/G cg20615401 chr6:28092323 ZSCAN16 0.44 5.9 0.31 8.92e-9 Parkinson's disease; CRC cis rs7264396 0.635 rs6060656 chr20:34466382 G/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.62 -10.32 -0.49 8.22e-22 Total cholesterol levels; CRC trans rs10802346 0.545 rs4478780 chr1:246372241 T/C cg13514129 chr1:39547527 MACF1 0.57 8.58 0.43 3.74e-16 Fractional exhaled nitric oxide (childhood); CRC cis rs7666738 0.830 rs7662596 chr4:99019962 G/T cg05340658 chr4:99064831 C4orf37 0.61 9.51 0.46 4.05e-19 Colonoscopy-negative controls vs population controls; CRC cis rs9914544 1.000 rs8066385 chr17:18761133 C/T cg26306683 chr17:18585705 ZNF286B 0.5 6.93 0.36 2.28e-11 Educational attainment (years of education); CRC cis rs4728302 0.869 rs10224683 chr7:133590937 A/G cg10665199 chr7:133106180 EXOC4 -0.4 -6.07 -0.32 3.43e-9 Intelligence;Intelligence (multi-trait analysis); CRC cis rs6952808 0.862 rs4721135 chr7:1912222 A/G cg04267008 chr7:1944627 MAD1L1 -0.63 -9.48 -0.46 5.17e-19 Bipolar disorder and schizophrenia; CRC cis rs2952156 0.920 rs2517957 chr17:37838716 G/A cg20243544 chr17:37824526 PNMT 0.56 8.97 0.44 2.35e-17 Asthma; CRC cis rs1008375 0.932 rs2302391 chr4:17660237 T/C cg02297831 chr4:17616191 MED28 0.48 6.25 0.33 1.25e-9 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs17270561 0.609 rs4712960 chr6:25727265 C/T cg16482183 chr6:26056742 HIST1H1C 0.83 10.59 0.5 9.49e-23 Iron status biomarkers; CRC cis rs6547741 0.935 rs6749426 chr2:27847606 T/C cg27432699 chr2:27873401 GPN1 0.79 14.22 0.62 4.06e-36 Oral cavity cancer; CRC cis rs10504229 1.000 rs60231757 chr8:58169937 T/C cg02725872 chr8:58115012 NA -0.38 -6.43 -0.33 4.44e-10 Developmental language disorder (linguistic errors); CRC cis rs1003719 0.788 rs4817849 chr21:38469796 A/G cg10648535 chr21:38446584 PIGP;TTC3 0.52 7.36 0.38 1.47e-12 Eye color traits; CRC cis rs6860806 0.531 rs2631359 chr5:131707892 C/T cg02033258 chr5:131593261 PDLIM4 -0.38 -6.39 -0.33 5.53e-10 Breast cancer; CRC cis rs34172651 0.837 rs12596793 chr16:24823667 C/G cg06028605 chr16:24865363 SLC5A11 0.37 6.87 0.35 3.24e-11 Intelligence (multi-trait analysis); CRC cis rs939584 1.000 rs10193244 chr2:647580 T/C cg03610516 chr2:642275 NA 0.41 5.93 0.31 7.83e-9 Body mass index; CRC cis rs2624839 0.704 rs13067082 chr3:50221715 A/G cg24110177 chr3:50126178 RBM5 0.43 5.98 0.31 5.67e-9 Intelligence (multi-trait analysis); CRC cis rs6502050 0.605 rs35158616 chr17:80094480 A/G cg19223190 chr17:80058835 NA 0.4 6.32 0.33 8.48e-10 Life satisfaction; CRC cis rs4727027 0.899 rs6464942 chr7:148826368 T/C cg12479418 chr7:148823350 ZNF425;ZNF398 0.41 5.61 0.3 4.31e-8 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC cis rs4731207 0.596 rs10258873 chr7:124650489 G/A cg23710748 chr7:124431027 NA -0.39 -6.25 -0.33 1.24e-9 Cutaneous malignant melanoma; CRC cis rs7843479 0.511 rs4379446 chr8:21777595 C/G cg16476235 chr8:21771668 DOK2 0.39 6.52 0.34 2.65e-10 Mean corpuscular volume; CRC cis rs2739330 0.731 rs2000468 chr22:24241611 G/T cg23131131 chr22:24373011 LOC391322 -0.62 -9.64 -0.47 1.52e-19 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs10791323 0.569 rs10791328 chr11:133713730 A/G cg15485101 chr11:133734466 NA 0.45 7.7 0.39 1.63e-13 Childhood ear infection; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg25789201 chr7:72395803 POM121 0.5 6.41 0.33 5.19e-10 Thyroid stimulating hormone; CRC cis rs9388451 0.839 rs3799711 chr6:126075313 C/T cg10911889 chr6:126070802 HEY2 -0.37 -5.61 -0.3 4.28e-8 Brugada syndrome; CRC cis rs6499188 0.571 rs1645975 chr16:68564448 C/T cg02972257 chr16:68554789 NA -0.58 -7.08 -0.36 9.03e-12 Ulcerative colitis; CRC cis rs1218582 0.710 rs4845687 chr1:154878911 A/G cg09359103 chr1:154839909 KCNN3 -0.71 -12.5 -0.57 1.33e-29 Prostate cancer; CRC cis rs72781680 0.611 rs56113233 chr2:24341085 A/C cg20701182 chr2:24300061 SF3B14 0.66 7.87 0.4 5.08e-14 Lymphocyte counts; CRC cis rs1707322 0.752 rs11211146 chr1:46109794 T/C cg06784218 chr1:46089804 CCDC17 0.65 12.4 0.56 3.08e-29 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs2032447 0.867 rs9295683 chr6:26069495 C/T cg04800585 chr6:26043546 HIST1H2BB 0.5 7.72 0.39 1.41e-13 Intelligence (multi-trait analysis); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg07936430 chr16:30538244 ZNF768 0.41 6.16 0.32 2.18e-9 Intelligence (multi-trait analysis); CRC cis rs1153858 0.943 rs7402632 chr15:45701913 A/T cg10760299 chr15:45669010 GATM 0.51 7.87 0.4 5.05e-14 Homoarginine levels; CRC cis rs6815814 0.950 rs66922907 chr4:38812537 A/G cg06935464 chr4:38784597 TLR10 0.56 5.79 0.3 1.6e-8 Breast cancer; CRC cis rs11098499 0.954 rs2389802 chr4:120325732 C/A cg09307838 chr4:120376055 NA 0.72 11.14 0.52 1.1e-24 Corneal astigmatism; CRC cis rs968567 0.906 rs61897793 chr11:61599347 G/A cg25303599 chr11:61595807 FADS2 -0.48 -5.95 -0.31 6.97e-9 Blood metabolite levels;Rheumatoid arthritis;Vitiligo;Glycerophospholipid levels; CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg11528995 chr1:117210575 IGSF3 0.39 6.56 0.34 2.13e-10 Obesity-related traits; CRC cis rs736408 0.609 rs13087772 chr3:52782274 T/G cg15147215 chr3:52552868 STAB1 -0.61 -10.05 -0.48 6.91e-21 Bipolar disorder; CRC cis rs2070488 0.775 rs762318 chr3:38516369 C/A cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.84 14.77 0.63 3.1e-38 Electrocardiographic conduction measures; CRC cis rs10504229 0.683 rs16921817 chr8:58107563 A/T cg04204079 chr8:58130323 NA -0.46 -5.79 -0.3 1.67e-8 Developmental language disorder (linguistic errors); CRC cis rs62084913 0.511 rs895690 chr17:72784649 C/T cg25054828 chr17:72772726 NAT9;TMEM104 0.61 9.57 0.47 2.64e-19 Breast cancer; CRC cis rs6952808 0.929 rs1801368 chr7:1976457 C/T cg22963979 chr7:1858916 MAD1L1 -0.54 -7.7 -0.39 1.61e-13 Bipolar disorder and schizophrenia; CRC cis rs951366 0.617 rs823075 chr1:205774897 C/T cg17178900 chr1:205818956 PM20D1 0.84 13.62 0.6 8.16e-34 Menarche (age at onset); CRC cis rs4660306 0.677 rs781062 chr1:45932738 T/A cg03123370 chr1:45965343 CCDC163P;MMACHC 0.49 6.5 0.34 3.01e-10 Homocysteine levels; CRC trans rs1005277 0.579 rs2749616 chr10:38510993 A/T cg27523141 chr10:43048294 ZNF37B 0.45 6.47 0.34 3.65e-10 Extrinsic epigenetic age acceleration; CRC cis rs10504229 0.683 rs7464038 chr8:58111908 T/C cg02290350 chr8:58132656 NA -0.57 -7.6 -0.39 3.18e-13 Developmental language disorder (linguistic errors); CRC cis rs4073582 0.555 rs521109 chr11:66030948 G/A cg14036092 chr11:66035641 RAB1B 0.57 9.24 0.45 3.19e-18 Gout; CRC cis rs8077889 0.719 rs57227660 chr17:41858984 T/C cg26893861 chr17:41843967 DUSP3 1.13 22.51 0.78 1.39e-68 Triglycerides; CRC cis rs62064224 0.553 rs9915115 chr17:30684858 A/G cg18200150 chr17:30822561 MYO1D 0.44 8.58 0.43 3.85e-16 Schizophrenia; CRC cis rs7085104 0.660 rs3781286 chr10:104595719 C/T cg15744005 chr10:104629667 AS3MT -0.35 -7.49 -0.38 6.59e-13 Immature fraction of reticulocytes;Schizophrenia; CRC trans rs703108 0.731 rs7898954 chr10:22323646 A/G cg02157667 chr16:85722621 GINS2 -0.53 -6.04 -0.32 4.27e-9 Monocyte percentage of white cells; CRC cis rs2228479 0.702 rs17177891 chr16:89799950 C/T cg06558623 chr16:89946397 TCF25 1.16 10.93 0.52 6.45e-24 Skin colour saturation; CRC trans rs7613875 0.620 rs13079006 chr3:49996924 G/T cg21659725 chr3:3221576 CRBN 0.44 6.46 0.34 3.74e-10 Body mass index; CRC cis rs6502050 0.835 rs8065556 chr17:80091176 G/C cg13198984 chr17:80129470 CCDC57 0.47 8.43 0.42 1.09e-15 Life satisfaction; CRC cis rs17065868 0.764 rs9533850 chr13:45011699 C/T cg10246903 chr13:45222710 NA 0.58 5.65 0.3 3.45e-8 Antineutrophil cytoplasmic antibody-associated vasculitis; CRC cis rs7660520 0.524 rs6839881 chr4:183729137 A/T cg12524338 chr4:183729343 NA 0.57 6.77 0.35 5.77e-11 Pediatric autoimmune diseases; CRC cis rs62064224 0.589 rs4523973 chr17:30809455 G/A cg18200150 chr17:30822561 MYO1D 0.48 9.62 0.47 1.82e-19 Schizophrenia; CRC cis rs4713118 0.662 rs175954 chr6:28011585 A/G cg12273811 chr6:28175739 NA 0.61 8.44 0.42 1.02e-15 Parkinson's disease; CRC cis rs780096 0.526 rs4803 chr2:27667297 A/G cg27432699 chr2:27873401 GPN1 -0.51 -7.82 -0.4 7.11e-14 Total body bone mineral density; CRC cis rs782590 0.837 rs809732 chr2:55914621 T/C cg18811423 chr2:55921094 PNPT1 0.88 17.33 0.69 2.92e-48 Metabolic syndrome; CRC trans rs9956878 0.555 rs8085188 chr18:73544676 A/G cg26819140 chr22:36925319 EIF3D -0.39 -6.1 -0.32 2.99e-9 Obesity-related traits; CRC cis rs9916302 0.904 rs3964723 chr17:37403979 C/T cg15445000 chr17:37608096 MED1 0.38 7.86 0.4 5.5e-14 Glomerular filtration rate (creatinine); CRC cis rs13118159 0.934 rs4974608 chr4:1356780 C/T cg20092199 chr4:1342459 KIAA1530 0.33 5.81 0.3 1.5e-8 Longevity; CRC cis rs8060686 0.925 rs9928531 chr16:67833171 T/C cg07125278 chr16:67683757 RLTPR -0.49 -6.54 -0.34 2.31e-10 HDL cholesterol;Metabolic syndrome; CRC trans rs7615952 0.932 rs3811679 chr3:125648283 A/G cg21747405 chr11:67723411 NA -0.43 -6.1 -0.32 2.97e-9 Blood pressure (smoking interaction); CRC cis rs28386778 0.897 rs8079818 chr17:61824667 C/G cg22520471 chr17:61851767 DDX42;CCDC47 0.74 11.53 0.54 4.6e-26 Prudent dietary pattern; CRC cis rs12681287 0.547 rs6998303 chr8:87510185 T/C cg27223183 chr8:87520930 FAM82B -0.52 -7.41 -0.38 1.05e-12 Caudate activity during reward; CRC cis rs2153535 0.562 rs9379211 chr6:8463927 C/T cg07606381 chr6:8435919 SLC35B3 0.68 10.9 0.51 8.26e-24 Motion sickness; CRC trans rs11098499 0.575 rs907205 chr4:120238664 G/C cg25214090 chr10:38739885 LOC399744 0.53 8.45 0.42 9.68e-16 Corneal astigmatism; CRC cis rs6952808 1.000 rs4449693 chr7:1884630 G/C cg00106254 chr7:1943704 MAD1L1 -0.43 -6.06 -0.32 3.75e-9 Bipolar disorder and schizophrenia; CRC cis rs9908102 0.756 rs7210890 chr17:12917134 A/G cg26162695 chr17:12921313 ELAC2 0.42 5.63 0.3 3.93e-8 Schizophrenia; CRC cis rs736408 0.812 rs2071506 chr3:52826276 T/C cg10802521 chr3:52805072 NEK4 -0.46 -6.61 -0.34 1.59e-10 Bipolar disorder; CRC cis rs6142102 0.886 rs6142098 chr20:32688294 A/C cg08999081 chr20:33150536 PIGU 0.36 5.62 0.3 4.17e-8 Skin pigmentation; CRC cis rs6951245 0.872 rs112309216 chr7:1100296 A/T cg04025307 chr7:1156635 C7orf50 0.64 6.81 0.35 4.53e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs2721195 0.874 rs2721173 chr8:145744429 C/T cg17328964 chr8:145687451 CYHR1 -0.57 -9.87 -0.48 2.62e-20 Age at first birth; CRC cis rs870825 0.616 rs28416641 chr4:185617999 C/T cg04058563 chr4:185651563 MLF1IP 0.72 9.38 0.46 1.12e-18 Blood protein levels; CRC cis rs9443189 0.762 rs2748944 chr6:76436106 A/G cg01950844 chr6:76311363 SENP6 0.65 8.62 0.43 2.94e-16 Prostate cancer; CRC cis rs11711311 1.000 rs12637067 chr3:113527606 A/G cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.52 -6.99 -0.36 1.51e-11 IgG glycosylation; CRC cis rs35110281 0.600 rs11089092 chr21:45120994 A/C cg04455712 chr21:45112962 RRP1B 0.41 7.82 0.4 7.36e-14 Mean corpuscular volume; CRC cis rs4713118 0.513 rs149941 chr6:28001033 T/C cg02631126 chr6:28058918 ZSCAN12L1 0.24 5.62 0.3 4.11e-8 Parkinson's disease; CRC cis rs736408 0.522 rs11716747 chr3:52748857 C/T cg18099408 chr3:52552593 STAB1 -0.46 -7.71 -0.39 1.48e-13 Bipolar disorder; CRC cis rs9322193 0.923 rs9800871 chr6:149965676 A/G cg05861140 chr6:150128134 PCMT1 -0.38 -6.16 -0.32 2.11e-9 Lung cancer; CRC cis rs9322193 0.961 rs4870144 chr6:149896676 C/G cg07701084 chr6:150067640 NUP43 0.54 7.8 0.4 8.21e-14 Lung cancer; CRC cis rs12024301 0.557 rs115625135 chr1:183644493 A/G cg11505048 chr1:183622726 RGL1;APOBEC4 0.76 6.85 0.35 3.67e-11 Peripheral arterial disease (traffic-related air pollution interaction); CRC trans rs3812111 0.609 rs549332 chr6:116454588 C/T cg25858983 chr17:42295711 UBTF 0.4 5.99 0.31 5.35e-9 Age-related macular degeneration; CRC cis rs2180341 1.000 rs7776136 chr6:127638348 A/T cg27446573 chr6:127587934 RNF146 0.96 14.2 0.62 5.23e-36 Breast cancer; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg26859586 chr10:104953231 NT5C2 0.37 6.08 0.32 3.31e-9 Liver disease severity in Alagille syndrome; CRC cis rs7666738 0.830 rs2865977 chr4:99017916 C/T cg17366294 chr4:99064904 C4orf37 0.43 7.27 0.37 2.72e-12 Colonoscopy-negative controls vs population controls; CRC cis rs72781680 0.898 rs56179550 chr2:23934867 C/T cg08917208 chr2:24149416 ATAD2B 0.99 9.37 0.46 1.21e-18 Lymphocyte counts; CRC cis rs6543140 0.964 rs4851593 chr2:103089227 C/T cg04239558 chr2:103089729 SLC9A4 -0.38 -6.73 -0.35 7.76e-11 Blood protein levels; CRC trans rs951252 0.504 rs11734405 chr4:146081096 C/T cg27367768 chr5:171615456 STK10 0.42 6.13 0.32 2.57e-9 Hip circumference; CRC cis rs17270561 0.609 rs9379788 chr6:25742759 A/C cg16482183 chr6:26056742 HIST1H1C 0.83 10.69 0.51 4.46e-23 Iron status biomarkers; CRC cis rs2067615 0.579 rs10861655 chr12:107129419 A/G cg13491945 chr12:107078410 RFX4 -0.34 -5.81 -0.31 1.45e-8 Heart rate; CRC cis rs929596 0.785 rs34352510 chr2:234650562 T/C cg02227331 chr2:234663937 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 0.41 5.76 0.3 1.9e-8 Total bilirubin levels in HIV-1 infection; CRC cis rs7917772 0.503 rs2031601 chr10:104308064 T/G cg11453585 chr10:104263688 ACTR1A;SUFU 0.89 17.29 0.69 4.24e-48 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC cis rs7811142 0.830 rs11768967 chr7:99967644 G/A cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.02 14.45 0.62 5.37e-37 Platelet count; CRC cis rs10256972 0.681 rs6979076 chr7:1116247 C/T cg04025307 chr7:1156635 C7orf50 -0.64 -10.07 -0.49 5.93e-21 Longevity;Endometriosis; CRC cis rs854765 0.647 rs854769 chr17:18019011 A/G cg23957660 chr17:17878224 LRRC48 -0.39 -6.91 -0.36 2.5e-11 Total body bone mineral density; CRC cis rs9443645 0.901 rs6454092 chr6:79701972 G/A cg05283184 chr6:79620031 NA -0.61 -9.66 -0.47 1.39e-19 Intelligence (multi-trait analysis); CRC cis rs7072216 0.763 rs12763044 chr10:100167451 C/G cg26618903 chr10:100175079 PYROXD2 -0.55 -9.26 -0.45 2.73e-18 Metabolite levels; CRC cis rs501916 0.796 rs75186419 chr15:48043934 G/A cg16110827 chr15:48056943 SEMA6D -0.53 -8.07 -0.41 1.33e-14 Inflammatory bowel disease;Ulcerative colitis; CRC cis rs736801 0.569 rs11748193 chr5:131725329 A/T cg14196790 chr5:131705035 SLC22A5 0.35 5.63 0.3 3.92e-8 Breast cancer;Mosquito bite size; CRC trans rs1814175 0.817 rs10769598 chr11:49669326 C/G cg03929089 chr4:120376271 NA -0.94 -17.84 -0.7 2.87e-50 Height; CRC cis rs2204008 0.689 rs1581357 chr12:38391479 C/G cg13010199 chr12:38710504 ALG10B 0.48 6.31 0.33 8.87e-10 Bladder cancer; CRC cis rs4713118 0.824 rs2179095 chr6:27750858 A/G cg25164649 chr6:28176230 NA -0.61 -8.1 -0.41 1.05e-14 Parkinson's disease; CRC trans rs1814175 0.511 rs61905634 chr11:49819736 G/A cg03929089 chr4:120376271 NA -0.96 -18.34 -0.71 3.01e-52 Height; CRC cis rs9462846 0.853 rs7765132 chr6:42872829 G/A cg21280719 chr6:42927975 GNMT -0.33 -6.47 -0.34 3.65e-10 Blood protein levels; CRC cis rs7605827 0.897 rs2241238 chr2:15656560 T/C cg19274914 chr2:15703543 NA 0.4 6.0 0.31 5.16e-9 Educational attainment (years of education); CRC cis rs738322 1.000 rs4379 chr22:38569171 T/C cg17652424 chr22:38574118 PLA2G6 -0.22 -6.81 -0.35 4.6e-11 Cutaneous nevi; CRC cis rs910316 0.967 rs4899551 chr14:75660246 C/G cg08847533 chr14:75593920 NEK9 -0.85 -14.66 -0.63 8.15e-38 Height; CRC cis rs7917772 0.502 rs2296583 chr10:104244322 T/G cg11453585 chr10:104263688 ACTR1A;SUFU 0.92 17.05 0.68 3.65e-47 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC cis rs10046574 0.831 rs17403220 chr7:135191705 A/G cg27474649 chr7:135195673 CNOT4 0.69 5.7 0.3 2.61e-8 Peripheral arterial disease (traffic-related air pollution interaction); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg10392504 chr7:5464594 TNRC18 0.51 7.29 0.37 2.39e-12 Response to antipsychotic treatment; CRC cis rs2898681 0.519 rs7670068 chr4:53733984 T/G cg21521518 chr4:53727714 RASL11B 0.4 5.86 0.31 1.12e-8 Optic nerve measurement (cup area); CRC cis rs7605827 0.930 rs13026732 chr2:15695429 G/A cg19274914 chr2:15703543 NA 0.37 5.62 0.3 4.13e-8 Educational attainment (years of education); CRC cis rs9467711 0.651 rs66790453 chr6:26107088 C/T cg19084075 chr6:26124329 HIST1H2AC;HIST1H2BC 0.63 5.89 0.31 9.72e-9 Autism spectrum disorder or schizophrenia; CRC cis rs4819052 0.851 rs9979545 chr21:46679805 G/A cg02159808 chr21:46707872 POFUT2;LOC642852 0.51 6.79 0.35 5.4e-11 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs1451375 0.617 rs1376524 chr7:50563582 G/A cg18232548 chr7:50535776 DDC -0.43 -5.73 -0.3 2.31e-8 Malaria; CRC cis rs1712517 0.524 rs4917384 chr10:104995788 T/C cg04362960 chr10:104952993 NT5C2 0.51 6.72 0.35 8.19e-11 Migraine; CRC cis rs10078 0.571 rs2671890 chr5:456457 A/G cg24955955 chr5:415729 AHRR 0.66 6.47 0.34 3.6e-10 Fat distribution (HIV); CRC cis rs728616 0.614 rs35395602 chr10:81906770 A/G cg11900509 chr10:81946545 ANXA11 -0.71 -8.0 -0.4 2.21e-14 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs826838 1.000 rs11183747 chr12:38822595 A/G cg26384229 chr12:38710491 ALG10B -0.73 -10.29 -0.49 1.06e-21 Heart rate; CRC cis rs7107174 1.000 rs2510055 chr11:77961912 C/T cg02023728 chr11:77925099 USP35 0.51 7.4 0.38 1.12e-12 Testicular germ cell tumor; CRC cis rs823143 0.570 rs823082 chr1:205786935 C/T cg14893161 chr1:205819251 PM20D1 -0.7 -11.35 -0.53 2.05e-25 Monocyte percentage of white cells; CRC cis rs9611565 0.569 rs188057 chr22:41822305 T/G cg06634786 chr22:41940651 POLR3H 0.7 7.77 0.39 1.03e-13 Vitiligo; CRC cis rs10242455 0.850 rs57367781 chr7:99116819 G/A cg18809830 chr7:99032528 PTCD1 -1.2 -8.64 -0.43 2.46e-16 Blood metabolite levels; CRC cis rs6502050 0.799 rs34448080 chr17:80121275 A/G cg13198984 chr17:80129470 CCDC57 0.47 8.35 0.42 1.88e-15 Life satisfaction; CRC cis rs7312933 0.703 rs11181380 chr12:42616040 A/T cg11827402 chr12:42719852 PPHLN1;ZCRB1 0.66 9.23 0.45 3.3e-18 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CRC cis rs10504229 0.861 rs57942497 chr8:58171239 G/T cg01721255 chr8:58191610 C8orf71 0.49 6.17 0.32 2e-9 Developmental language disorder (linguistic errors); CRC cis rs10504229 1.000 rs58382845 chr8:58169851 A/C cg22535103 chr8:58192502 C8orf71 -0.81 -11.98 -0.55 1.05e-27 Developmental language disorder (linguistic errors); CRC cis rs9914988 0.887 rs4795456 chr17:27072463 G/A cg07195577 chr17:27052828 TLCD1 0.42 6.16 0.32 2.09e-9 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs6728642 0.519 rs59131346 chr2:97566768 C/T cg26665480 chr2:98280029 ACTR1B -0.54 -5.9 -0.31 9.2e-9 Bipolar disorder lithium response (continuous) or schizophrenia; CRC cis rs769267 0.895 rs2965189 chr19:19519518 G/T cg01262667 chr19:19385393 TM6SF2 0.35 5.91 0.31 8.35e-9 Tonsillectomy; CRC cis rs2034088 0.833 rs9748016 chr17:410451 G/T cg06217071 chr17:408420 NA 0.33 7.23 0.37 3.41e-12 Hip circumference adjusted for BMI; CRC cis rs8060686 0.641 rs79577483 chr16:68036939 A/G cg08314208 chr16:67682810 RLTPR -0.64 -6.87 -0.35 3.23e-11 HDL cholesterol;Metabolic syndrome; CRC cis rs1552244 0.752 rs9867091 chr3:10043429 T/C cg02579736 chr3:10068473 FANCD2;CIDECP 0.88 11.72 0.54 9.53e-27 Alzheimer's disease; CRC trans rs10982213 0.830 rs2274163 chr9:117188714 C/T cg06643102 chr19:8455567 RAB11B 0.43 6.66 0.34 1.15e-10 Interleukin-6 levels; CRC cis rs7666738 0.830 rs62318503 chr4:98935479 T/C cg05340658 chr4:99064831 C4orf37 0.6 9.35 0.46 1.41e-18 Colonoscopy-negative controls vs population controls; CRC cis rs611744 0.573 rs629996 chr8:109255206 C/T cg21045802 chr8:109455806 TTC35 0.46 7.05 0.36 1.06e-11 Dupuytren's disease; CRC cis rs9649213 0.593 rs35535338 chr7:97962319 C/T cg08684580 chr7:98029266 BAIAP2L1 -0.32 -5.65 -0.3 3.44e-8 Prostate cancer (SNP x SNP interaction); CRC cis rs12908161 0.959 rs12908699 chr15:85240403 G/T cg17507749 chr15:85114479 UBE2QP1 0.63 8.94 0.44 2.78e-17 Schizophrenia; CRC cis rs1129187 0.791 rs1129186 chr6:42932202 C/T cg02353165 chr6:42928485 GNMT 0.72 12.29 0.56 7.76e-29 Alzheimer's disease in APOE e4+ carriers; CRC cis rs6912958 0.712 rs6454641 chr6:88371060 T/C cg08069147 chr6:88032118 GJB7;C6orf162 -0.54 -8.07 -0.41 1.32e-14 Monocyte percentage of white cells; CRC cis rs4853036 0.951 rs6710444 chr2:70120632 G/A cg02498382 chr2:70120550 SNRNP27 -0.44 -6.67 -0.35 1.1e-10 Colorectal or endometrial cancer; CRC cis rs172166 0.694 rs203884 chr6:28077374 G/T cg21251018 chr6:28226885 NKAPL 0.47 7.26 0.37 2.86e-12 Cardiac Troponin-T levels; CRC cis rs11622475 1.000 rs11622475 chr14:104509076 C/T cg20488157 chr14:104394430 TDRD9 0.69 8.52 0.43 5.94e-16 Bipolar disorder; CRC cis rs7666738 0.830 rs3846444 chr4:99032888 T/C cg17366294 chr4:99064904 C4orf37 0.44 7.48 0.38 6.96e-13 Colonoscopy-negative controls vs population controls; CRC cis rs1577917 0.655 rs1059307 chr6:86387888 G/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A 0.52 7.53 0.38 5.06e-13 Response to antipsychotic treatment; CRC cis rs2180341 0.782 rs6912006 chr6:127722631 C/T cg24812749 chr6:127587940 RNF146 0.55 7.22 0.37 3.67e-12 Breast cancer; CRC cis rs873946 0.586 rs3793682 chr10:134564563 C/T cg06453172 chr10:134556979 INPP5A -0.69 -8.23 -0.41 4.32e-15 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CRC cis rs9814567 0.574 rs1391695 chr3:134171376 T/G cg06109529 chr3:134205091 CEP63;ANAPC13 -0.57 -8.29 -0.42 2.91e-15 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg00287636 chr16:49892218 NA 0.35 6.48 0.34 3.38e-10 Liver disease severity in Alagille syndrome; CRC cis rs7312933 0.501 rs3810793 chr12:42729407 C/T cg11827402 chr12:42719852 PPHLN1;ZCRB1 0.63 9.02 0.45 1.58e-17 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CRC cis rs826838 1.000 rs11168676 chr12:38977304 A/G cg26384229 chr12:38710491 ALG10B 0.72 10.14 0.49 3.26e-21 Heart rate; CRC cis rs394563 0.967 rs447025 chr6:149799128 A/C cg03678062 chr6:149772716 ZC3H12D -0.35 -6.19 -0.32 1.76e-9 Dupuytren's disease; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg06329143 chr18:48556512 SMAD4 0.48 6.13 0.32 2.54e-9 Anxiety disorder; CRC cis rs4819052 0.851 rs2236446 chr21:46678985 T/C cg19498844 chr21:46707878 POFUT2;LOC642852 0.71 10.25 0.49 1.36e-21 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs116095464 0.558 rs10080225 chr5:232175 A/G cg22496380 chr5:211416 CCDC127 -0.88 -10.28 -0.49 1.1e-21 Breast cancer; CRC cis rs2712184 0.868 rs1548946 chr2:217665368 C/T cg05032264 chr2:217675019 NA -0.33 -5.62 -0.3 4.15e-8 Glomerular filtration rate;Glomerular filtration rate in non diabetics (creatinine); CRC cis rs2346160 0.899 rs206974 chr6:167690300 G/A cg04673565 chr6:167680447 NA -0.41 -6.85 -0.35 3.72e-11 Parental extreme longevity (95 years and older); CRC cis rs7246657 1.000 rs1529957 chr19:37739801 A/G cg23950597 chr19:37808831 NA -0.49 -5.79 -0.3 1.68e-8 Coronary artery calcification; CRC cis rs9828933 0.938 rs9809432 chr3:64002953 G/A cg16258503 chr3:63850278 ATXN7;THOC7 -0.56 -6.27 -0.33 1.14e-9 Type 2 diabetes; CRC trans rs10504229 0.861 rs114700910 chr8:58170642 C/T cg04077850 chr5:125800366 GRAMD3 0.37 6.09 0.32 3.12e-9 Developmental language disorder (linguistic errors); CRC cis rs208520 1.000 rs208529 chr6:66957549 T/C cg07460842 chr6:66804631 NA -0.92 -11.43 -0.53 1.04e-25 Exhaled nitric oxide output; CRC cis rs60871478 1.000 rs34086011 chr7:805430 C/T cg13844804 chr7:814759 HEATR2 0.65 8.47 0.42 8.48e-16 Cerebrospinal P-tau181p levels; CRC trans rs1712517 0.873 rs7913461 chr10:105001325 A/G cg23009290 chr3:125982568 NA -0.35 -6.25 -0.33 1.27e-9 Migraine; CRC cis rs1008375 0.966 rs6832387 chr4:17697546 G/T cg16339924 chr4:17578868 LAP3 0.49 6.63 0.34 1.35e-10 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs1878931 0.507 rs4429296 chr16:3408277 T/G cg26668626 chr16:3451006 ZNF174;ZNF434 -0.47 -5.67 -0.3 3.06e-8 Body mass index (adult); CRC cis rs9487051 1.000 rs9480924 chr6:109617070 T/C cg21918786 chr6:109611834 NA -0.38 -6.51 -0.34 2.81e-10 Reticulocyte fraction of red cells; CRC cis rs769267 0.965 rs4808937 chr19:19398005 A/G cg17414380 chr19:19431394 KIAA0892;SF4 0.41 5.64 0.3 3.59e-8 Tonsillectomy; CRC cis rs2404602 0.536 rs7165025 chr15:76766434 G/A cg22467129 chr15:76604101 ETFA -0.44 -7.55 -0.38 4.43e-13 Blood metabolite levels; CRC cis rs6424115 1.000 rs974698 chr1:24132785 C/T cg10978503 chr1:24200527 CNR2 0.47 8.54 0.43 5.02e-16 Immature fraction of reticulocytes; CRC cis rs6076065 0.683 rs2424557 chr20:23422159 C/G cg11657817 chr20:23433608 CST11 -0.44 -6.63 -0.34 1.4e-10 Facial morphology (factor 15, philtrum width); CRC cis rs709400 0.930 rs2274268 chr14:104029378 C/G cg08213375 chr14:104286397 PPP1R13B -0.34 -5.65 -0.3 3.45e-8 Body mass index; CRC trans rs951252 0.504 rs11734405 chr4:146081096 C/T cg06361278 chr17:25783929 NA 0.48 6.11 0.32 2.86e-9 Hip circumference; CRC cis rs6076065 0.748 rs6048781 chr20:23380027 T/C cg11657817 chr20:23433608 CST11 0.54 9.38 0.46 1.08e-18 Facial morphology (factor 15, philtrum width); CRC cis rs4969178 0.930 rs12452576 chr17:76386037 A/C cg20026190 chr17:76395443 PGS1 0.38 5.91 0.31 8.64e-9 HDL cholesterol levels; CRC cis rs6696846 0.740 rs17344537 chr1:205091427 T/G cg03948781 chr1:205179583 DSTYK 0.43 6.13 0.32 2.56e-9 Red blood cell count; CRC cis rs4563143 0.675 rs73029050 chr19:29276554 G/T cg12756686 chr19:29218302 NA 0.61 9.12 0.45 7.78e-18 Methadone dose in opioid dependence; CRC cis rs12711979 0.509 rs1031478 chr2:3827425 G/A cg17052675 chr2:3827356 NA -0.86 -20.97 -0.76 1.37e-62 Itch intensity from mosquito bite adjusted by bite size; CRC cis rs10876993 0.928 rs2640629 chr12:58065448 C/T cg18357645 chr12:58087776 OS9 0.59 8.35 0.42 1.89e-15 Celiac disease or Rheumatoid arthritis; CRC trans rs11148252 0.967 rs4286007 chr13:53022518 A/G cg18335740 chr13:41363409 SLC25A15 0.56 8.81 0.44 7.2e-17 Lewy body disease; CRC cis rs875971 1.000 rs778694 chr7:65871558 A/G cg18876405 chr7:65276391 NA 0.52 9.04 0.45 1.37e-17 Aortic root size; CRC trans rs2303319 0.504 rs56009150 chr2:162598582 T/C cg22627826 chr19:1240265 ATP5D -0.72 -6.18 -0.32 1.86e-9 Cognitive function; CRC cis rs2456568 0.803 rs10831142 chr11:93640781 A/G cg26875233 chr11:93583750 C11orf90 0.3 6.05 0.32 4.05e-9 Response to serotonin reuptake inhibitors in major depressive disorder; CRC cis rs3741151 1.000 rs79778136 chr11:73041339 T/C cg17517138 chr11:73019481 ARHGEF17 1.08 9.34 0.46 1.51e-18 GIP levels in response to oral glucose tolerance test (120 minutes); CRC cis rs9796 0.727 rs12101934 chr15:41353079 C/T cg18705301 chr15:41695430 NDUFAF1 -0.38 -6.22 -0.32 1.49e-9 Menopause (age at onset); CRC cis rs394563 0.591 rs237035 chr6:149710848 C/T cg16235748 chr6:149772707 ZC3H12D -0.39 -7.02 -0.36 1.25e-11 Dupuytren's disease; CRC cis rs4253772 0.591 rs6520010 chr22:46721223 G/A cg24881330 chr22:46731750 TRMU 0.71 8.88 0.44 4.41e-17 LDL cholesterol;Cholesterol, total; CRC cis rs4862750 0.914 rs6837117 chr4:187872379 C/T cg11301795 chr4:187892539 NA -0.84 -18.03 -0.71 4.84e-51 Lobe attachment (rater-scored or self-reported); CRC cis rs1862618 0.853 rs33322 chr5:56175226 A/G cg03609598 chr5:56110824 MAP3K1 -0.85 -10.06 -0.49 6.18e-21 Initial pursuit acceleration; CRC cis rs9747201 0.926 rs8065606 chr17:80063526 G/A cg09264619 chr17:80180166 NA 0.52 7.44 0.38 8.67e-13 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs2115630 1.000 rs11854313 chr15:85304048 G/C cg11189052 chr15:85197271 WDR73 -0.62 -10.01 -0.48 9.3e-21 P wave terminal force; CRC cis rs6674176 0.628 rs3828146 chr1:44428715 C/T cg15962314 chr1:44399869 ARTN 0.29 5.74 0.3 2.17e-8 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Cognitive ability; CRC cis rs9916302 0.768 rs62077464 chr17:37656056 C/G cg03013999 chr17:37608204 MED1 0.45 6.83 0.35 4.15e-11 Glomerular filtration rate (creatinine); CRC cis rs17270561 0.609 rs9358871 chr6:25726675 G/A cg17691542 chr6:26056736 HIST1H1C 0.73 9.31 0.46 1.82e-18 Iron status biomarkers; CRC cis rs3764400 0.567 rs4995899 chr17:46150730 G/A cg10706073 chr17:46328419 SKAP1 -0.62 -6.71 -0.35 8.77e-11 Body mass index; CRC cis rs7618915 0.547 rs62253703 chr3:52632357 T/C cg18099408 chr3:52552593 STAB1 -0.44 -7.31 -0.37 2e-12 Bipolar disorder; CRC cis rs908922 0.676 rs1337338 chr1:152511885 G/A cg09873164 chr1:152488093 CRCT1 0.38 6.4 0.33 5.37e-10 Hair morphology; CRC cis rs225245 0.782 rs321618 chr17:33912404 A/G cg05299278 chr17:33885742 SLFN14 0.49 7.89 0.4 4.47e-14 Reticulocyte count;Reticulocyte fraction of red cells;High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells; CRC cis rs9649213 0.593 rs6949214 chr7:97960233 G/A cg21770322 chr7:97807741 LMTK2 0.52 8.54 0.43 5.11e-16 Prostate cancer (SNP x SNP interaction); CRC cis rs6426558 0.537 rs2670462 chr1:227432923 C/G cg10327440 chr1:227177885 CDC42BPA -0.41 -6.17 -0.32 2.01e-9 Neutrophil percentage of white cells; CRC cis rs6951245 1.000 rs77083167 chr7:1071823 C/T cg03188948 chr7:1209495 NA 0.63 6.52 0.34 2.64e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs989128 0.614 rs8077587 chr17:48626575 C/T cg16068336 chr17:48637367 CACNA1G -0.54 -7.73 -0.39 1.3e-13 Type 2 diabetes; CRC cis rs6952808 0.500 rs3778996 chr7:2177190 G/A cg04267008 chr7:1944627 MAD1L1 -0.62 -8.4 -0.42 1.31e-15 Bipolar disorder and schizophrenia; CRC cis rs7208859 0.673 rs450585 chr17:28951039 G/A cg13385521 chr17:29058706 SUZ12P 0.46 5.95 0.31 6.82e-9 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs6831352 0.877 rs28987101 chr4:100049253 T/G cg13256891 chr4:100009986 ADH5 -0.66 -8.89 -0.44 4.04e-17 Alcohol dependence; CRC cis rs2019137 0.936 rs2241978 chr2:113954006 A/G cg21482265 chr2:113992762 PAX8;LOC440839;LOC654433 -0.48 -6.77 -0.35 5.81e-11 Lymphocyte counts; CRC cis rs13108904 0.557 rs1680033 chr4:1243404 C/T cg15763984 chr4:1342303 KIAA1530 -0.38 -5.97 -0.31 6.08e-9 Obesity-related traits; CRC cis rs7216064 1.000 rs4791212 chr17:65975385 C/T cg12091567 chr17:66097778 LOC651250 -0.64 -7.53 -0.38 4.91e-13 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg00051782 chr3:193859210 NA 0.45 6.4 0.33 5.35e-10 Intelligence (multi-trait analysis); CRC cis rs7264396 0.690 rs2425175 chr20:34445563 G/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.6 -10.19 -0.49 2.18e-21 Total cholesterol levels; CRC cis rs10504073 0.647 rs9643395 chr8:50014500 A/C cg00325661 chr8:49890786 NA 0.45 8.21 0.41 4.98e-15 Blood metabolite ratios; CRC cis rs2404602 0.583 rs2456076 chr15:76557553 T/G cg26408565 chr15:76604113 ETFA 0.37 5.85 0.31 1.2e-8 Blood metabolite levels; CRC cis rs919433 0.929 rs7592511 chr2:198177974 A/G cg03934865 chr2:198174659 NA -0.44 -8.05 -0.41 1.48e-14 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC cis rs4073582 0.595 rs528842 chr11:66032390 G/A cg16950941 chr11:66035639 RAB1B 0.71 12.11 0.56 3.69e-28 Gout; CRC cis rs7618915 0.571 rs33964154 chr3:52596914 A/G cg07507251 chr3:52567010 NT5DC2 0.43 6.2 0.32 1.68e-9 Bipolar disorder; CRC cis rs3736485 0.934 rs1902592 chr15:51881980 C/T cg08986416 chr15:51914746 DMXL2 -0.46 -6.56 -0.34 2.11e-10 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs9611565 0.681 rs6002372 chr22:41801299 A/T cg03806693 chr22:41940476 POLR3H 1.04 12.91 0.58 3.83e-31 Vitiligo; CRC cis rs4713118 0.662 rs9468274 chr6:28026077 G/T cg12273811 chr6:28175739 NA 0.62 8.29 0.42 2.87e-15 Parkinson's disease; CRC cis rs72717009 0.825 rs61802846 chr1:161473873 A/C cg10431340 chr1:161279108 MPZ -0.56 -7.42 -0.38 1.04e-12 Rheumatoid arthritis; CRC cis rs6762477 0.505 rs17304079 chr3:50085153 A/G cg05623727 chr3:50126028 RBM5 0.53 6.86 0.35 3.52e-11 Menarche (age at onset); CRC cis rs6499255 0.904 rs7190652 chr16:69616292 C/G cg15192750 chr16:69999425 NA 0.59 7.79 0.39 8.66e-14 IgE levels; CRC cis rs422249 0.512 rs174566 chr11:61592362 A/G cg06781209 chr11:61594997 FADS2 -0.39 -5.96 -0.31 6.66e-9 Trans fatty acid levels; CRC cis rs7605827 0.930 rs12692273 chr2:15688834 G/C cg19274914 chr2:15703543 NA 0.39 5.9 0.31 9.16e-9 Educational attainment (years of education); CRC cis rs780096 0.526 rs1647266 chr2:27693485 T/C cg12000995 chr2:27665139 KRTCAP3 -0.32 -6.67 -0.35 1.1e-10 Total body bone mineral density; CRC cis rs9309473 0.607 rs7567017 chr2:73596270 C/T cg20560298 chr2:73613845 ALMS1 -0.5 -7.0 -0.36 1.44e-11 Metabolite levels; CRC cis rs9649465 0.934 rs7799354 chr7:123269819 A/G cg03229431 chr7:123269106 ASB15 -0.41 -6.37 -0.33 6.52e-10 Migraine; CRC cis rs853679 0.517 rs4713152 chr6:28137454 G/A cg02683197 chr6:28174875 NA 0.87 10.73 0.51 3.25e-23 Depression; CRC cis rs9916302 0.861 rs3889368 chr17:37683231 C/T cg03013999 chr17:37608204 MED1 0.46 6.98 0.36 1.66e-11 Glomerular filtration rate (creatinine); CRC cis rs116095464 0.558 rs9312978 chr5:221930 C/G cg22857025 chr5:266934 NA -1.14 -12.02 -0.55 7.44e-28 Breast cancer; CRC cis rs172166 0.543 rs1150691 chr6:28168033 A/G cg25164649 chr6:28176230 NA 0.49 7.0 0.36 1.46e-11 Cardiac Troponin-T levels; CRC cis rs79149102 0.579 rs7163390 chr15:75280426 T/C cg09165964 chr15:75287851 SCAMP5 -0.56 -5.89 -0.31 9.55e-9 Lung cancer; CRC cis rs3741151 1.000 rs76887714 chr11:73045500 C/T cg17517138 chr11:73019481 ARHGEF17 0.66 6.9 0.36 2.6e-11 GIP levels in response to oral glucose tolerance test (120 minutes); CRC cis rs17767392 0.915 rs1990241 chr14:71774052 T/G cg13720639 chr14:72061746 SIPA1L1 -0.54 -6.9 -0.36 2.71e-11 Mitral valve prolapse; CRC cis rs798554 0.836 rs13243214 chr7:2817455 G/T cg19346786 chr7:2764209 NA -0.44 -7.65 -0.39 2.29e-13 Height; CRC cis rs8060686 0.920 rs73591968 chr16:67803063 G/A cg26727032 chr16:67993705 SLC12A4 -0.6 -6.97 -0.36 1.69e-11 HDL cholesterol;Metabolic syndrome; CRC cis rs6500395 1.000 rs7195684 chr16:48710750 G/A cg04672837 chr16:48644449 N4BP1 -0.45 -6.64 -0.34 1.33e-10 Response to tocilizumab in rheumatoid arthritis; CRC cis rs4862750 0.957 rs4861733 chr4:187903933 C/T cg11301795 chr4:187892539 NA -0.89 -19.86 -0.74 3e-58 Lobe attachment (rater-scored or self-reported); CRC cis rs1691799 0.777 rs11176145 chr12:66719795 A/G cg16791601 chr12:66731901 HELB 0.64 10.25 0.49 1.38e-21 White blood cell count (basophil); CRC cis rs3858526 0.839 rs10466484 chr11:5943696 A/G cg05234568 chr11:5960015 NA -0.53 -7.31 -0.37 2.04e-12 DNA methylation (variation); CRC cis rs7809950 0.678 rs62483640 chr7:106900214 T/G cg23024343 chr7:107201750 COG5 -0.73 -9.89 -0.48 2.39e-20 Coronary artery disease; CRC cis rs1577917 1.000 rs12201880 chr6:86627007 G/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.52 -6.78 -0.35 5.63e-11 Response to antipsychotic treatment; CRC trans rs9329221 0.683 rs814359 chr8:9883132 T/G cg06636001 chr8:8085503 FLJ10661 -0.54 -8.19 -0.41 6.01e-15 Neuroticism; CRC cis rs7487075 0.820 rs7304622 chr12:46698860 G/A cg22049899 chr12:47219821 SLC38A4 0.33 6.13 0.32 2.48e-9 Itch intensity from mosquito bite; CRC cis rs2708977 0.901 rs2579505 chr2:97167962 T/C cg01950434 chr2:97203154 ARID5A -0.43 -6.36 -0.33 6.68e-10 Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes; CRC cis rs950169 0.920 rs2135551 chr15:84707851 A/G cg11189052 chr15:85197271 WDR73 0.61 8.89 0.44 4.18e-17 Schizophrenia; CRC cis rs644799 0.965 rs11021310 chr11:95502106 A/C cg25622487 chr11:95524042 FAM76B;CEP57 0.74 11.31 0.53 2.84e-25 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs6582630 0.584 rs12832156 chr12:38419435 C/T cg26384229 chr12:38710491 ALG10B -0.52 -7.38 -0.38 1.31e-12 Drug-induced liver injury (flucloxacillin); CRC cis rs9292777 0.834 rs1992660 chr5:40415067 C/T cg09067459 chr5:40385259 NA 0.53 9.31 0.46 1.8e-18 Crohn's disease;Multiple sclerosis; CRC cis rs2602836 0.830 rs2602874 chr4:100039396 A/T cg13256891 chr4:100009986 ADH5 0.57 8.66 0.43 2.16e-16 HDL cholesterol;HDL cholesterol levels; CRC cis rs12200560 0.524 rs1413525 chr6:97073096 C/T cg06623918 chr6:96969491 KIAA0776 0.57 8.11 0.41 9.85e-15 Coronary heart disease; CRC cis rs7552404 0.807 rs2066183 chr1:76153745 A/G cg03433033 chr1:76189801 ACADM 0.92 14.2 0.62 4.86e-36 Blood metabolite levels;Acylcarnitine levels; CRC cis rs13118159 0.550 rs1137789 chr4:1381798 A/G cg05025164 chr4:1340916 KIAA1530 0.53 7.56 0.38 4.13e-13 Longevity; CRC cis rs1577917 0.958 rs12193904 chr6:86452703 C/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.61 -7.81 -0.4 7.72e-14 Response to antipsychotic treatment; CRC cis rs9928842 1.000 rs9928842 chr16:75242867 T/C cg08657710 chr16:75258780 CTRB1 -0.59 -6.82 -0.35 4.37e-11 Alcoholic chronic pancreatitis; CRC cis rs1552244 0.882 rs34706481 chr3:10004123 G/A cg08888203 chr3:10149979 C3orf24 0.57 7.15 0.37 5.56e-12 Alzheimer's disease; CRC trans rs60843830 1.000 rs58461606 chr2:267367 G/T cg11347411 chr7:150020925 ACTR3C;LRRC61 0.59 9.21 0.45 3.84e-18 Spherical equivalent (joint analysis main effects and education interaction); CRC cis rs929354 0.772 rs2023977 chr7:156996022 C/G cg05182265 chr7:156933206 UBE3C -0.76 -14.52 -0.62 3.01e-37 Body mass index; CRC cis rs28386778 0.863 rs3760256 chr17:61821161 A/G cg11494091 chr17:61959527 GH2 0.6 10.29 0.49 1.01e-21 Prudent dietary pattern; CRC cis rs921968 0.521 rs56923478 chr2:219638539 A/G cg02176678 chr2:219576539 TTLL4 -0.4 -6.52 -0.34 2.67e-10 Mean corpuscular hemoglobin concentration; CRC cis rs1552244 0.882 rs36006511 chr3:10054191 C/T cg00166722 chr3:10149974 C3orf24 0.63 8.16 0.41 7.3e-15 Alzheimer's disease; CRC cis rs524281 0.861 rs2293121 chr11:65961347 T/G cg14036092 chr11:66035641 RAB1B -0.47 -5.74 -0.3 2.13e-8 Electroencephalogram traits; CRC trans rs1973993 0.691 rs11165623 chr1:96893000 G/A cg10631902 chr5:14652156 NA 0.58 11.42 0.53 1.13e-25 Weight; CRC cis rs875971 0.862 rs2024192 chr7:66041447 G/T cg12463550 chr7:65579703 CRCP -0.47 -6.39 -0.33 5.7e-10 Aortic root size; CRC cis rs861020 0.630 rs627069 chr1:210004613 C/G cg05527609 chr1:210001259 C1orf107 0.77 10.68 0.51 4.51e-23 Orofacial clefts; CRC cis rs11112613 0.762 rs17037312 chr12:105950085 C/T cg03607813 chr12:105948248 NA 0.82 10.85 0.51 1.21e-23 Corrected insulin response;Corrected insulin response adjusted for insulin sensitivity index; CRC cis rs12024301 0.557 rs16861243 chr1:183589382 A/G cg11505048 chr1:183622726 RGL1;APOBEC4 -0.76 -7.03 -0.36 1.21e-11 Peripheral arterial disease (traffic-related air pollution interaction); CRC trans rs1814175 0.791 rs7395713 chr11:49877887 A/G cg11707556 chr5:10655725 ANKRD33B -0.44 -8.39 -0.42 1.42e-15 Height; CRC cis rs9640161 0.750 rs1983440 chr7:150023941 G/C cg13722127 chr7:150037890 RARRES2 0.5 7.84 0.4 6.35e-14 Blood protein levels;Circulating chemerin levels; CRC cis rs948562 0.647 rs71486418 chr11:58240133 C/T cg15696309 chr11:58395628 NA -0.57 -8.73 -0.43 1.3e-16 Lymphoma; CRC cis rs9816226 0.645 rs16860471 chr3:185847441 G/T cg00760338 chr3:185826511 ETV5 -0.67 -6.26 -0.33 1.2e-9 Obesity;Body mass index; CRC cis rs72945132 0.882 rs72947012 chr11:70149472 G/A cg00319359 chr11:70116639 PPFIA1 0.65 6.53 0.34 2.47e-10 Coronary artery disease; CRC cis rs2180341 0.781 rs6913350 chr6:127570560 C/T cg27446573 chr6:127587934 RNF146 0.74 10.88 0.51 9.48e-24 Breast cancer; CRC cis rs2762353 0.595 rs9467591 chr6:25742699 C/T cg12310025 chr6:25882481 NA -0.7 -10.23 -0.49 1.65e-21 Blood metabolite levels; CRC cis rs62432291 0.681 rs420054 chr6:159655084 C/G cg14500486 chr6:159655392 FNDC1 -0.76 -10.41 -0.5 4.01e-22 Joint mobility (Beighton score); CRC cis rs2204008 0.745 rs8189516 chr12:38239084 C/T cg13010199 chr12:38710504 ALG10B 0.45 5.8 0.3 1.52e-8 Bladder cancer; CRC trans rs3942852 0.868 rs58407618 chr11:48104167 T/G cg15704280 chr7:45808275 SEPT13 -0.62 -7.2 -0.37 4.05e-12 Acute lymphoblastic leukemia (childhood); CRC cis rs7811142 0.830 rs76798830 chr7:99952828 C/T cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.56 6.91 0.36 2.5e-11 Platelet count; CRC cis rs7894051 1.000 rs4345885 chr10:135191311 T/C cg20534287 chr10:135191450 PAOX 0.76 5.9 0.31 9.19e-9 Lifespan; CRC cis rs13256369 0.802 rs11249884 chr8:8561552 C/T cg06671706 chr8:8559999 CLDN23 -0.64 -9.58 -0.47 2.42e-19 Obesity-related traits; CRC cis rs9649213 0.574 rs13238610 chr7:97909277 T/C cg21770322 chr7:97807741 LMTK2 0.55 9.2 0.45 4.12e-18 Prostate cancer (SNP x SNP interaction); CRC cis rs6570726 0.935 rs451349 chr6:145820894 A/G cg05347473 chr6:146136440 FBXO30 0.37 6.0 0.31 5.27e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs6500602 0.927 rs7200817 chr16:4480598 G/C cg08645402 chr16:4508243 NA 0.56 9.33 0.46 1.59e-18 Schizophrenia; CRC cis rs9894429 0.646 rs12948797 chr17:79617384 G/A cg18240062 chr17:79603768 NPLOC4 0.47 7.13 0.37 6.29e-12 Eye color traits; CRC trans rs1814175 0.619 rs847644 chr11:49918418 G/A cg15704280 chr7:45808275 SEPT13 -0.95 -16.82 -0.68 3.11e-46 Height; CRC cis rs738322 0.934 rs84473 chr22:38557326 T/C cg25457927 chr22:38595422 NA -0.34 -7.16 -0.37 5.41e-12 Cutaneous nevi; CRC trans rs12310956 0.515 rs115836245 chr12:33951369 T/C cg26384229 chr12:38710491 ALG10B 0.46 6.31 0.33 9.21e-10 Morning vs. evening chronotype; CRC cis rs16975963 0.843 rs113690074 chr19:38375393 G/A cg15135657 chr19:38346511 NA -0.43 -5.76 -0.3 1.96e-8 Longevity; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg13551243 chr8:146052742 ZNF7 0.4 5.98 0.31 5.8e-9 Liver disease severity in Alagille syndrome; CRC cis rs2249694 0.959 rs2987799 chr10:135380499 T/G cg16964102 chr10:135390573 NA -0.41 -6.76 -0.35 6.47e-11 Obesity-related traits; CRC cis rs2976388 0.647 rs2585154 chr8:143783485 C/T cg05569086 chr8:143859399 LYNX1 0.37 6.33 0.33 8e-10 Urinary tract infection frequency; CRC cis rs11608355 1.000 rs10774695 chr12:109868040 G/A cg19025524 chr12:109796872 NA -0.47 -6.75 -0.35 6.8e-11 Neuroticism; CRC trans rs1728785 1.000 rs1645927 chr16:68589300 T/G cg04657470 chr2:198365150 HSPE1;HSPD1 0.59 7.1 0.36 7.97e-12 Ulcerative colitis; CRC cis rs853679 0.546 rs200995 chr6:27813694 C/T cg19041857 chr6:27730383 NA 0.73 7.06 0.36 9.84e-12 Depression; CRC cis rs6502050 0.835 rs4789677 chr17:80119842 A/G cg02741985 chr17:80059408 CCDC57 0.43 7.15 0.37 5.59e-12 Life satisfaction; CRC cis rs4964805 0.954 rs10861104 chr12:104189923 A/C cg02344784 chr12:104178138 NT5DC3 0.51 7.21 0.37 3.89e-12 Attention deficit hyperactivity disorder; CRC cis rs7615952 0.599 rs2279821 chr3:125734308 G/A cg18479299 chr3:125709523 NA -0.55 -6.44 -0.33 4.23e-10 Blood pressure (smoking interaction); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg02632015 chr17:19551762 ALDH3A2 0.4 6.48 0.34 3.28e-10 Liver disease severity in Alagille syndrome; CRC cis rs3736485 0.844 rs17603116 chr15:51786877 G/A cg08986416 chr15:51914746 DMXL2 -0.44 -6.26 -0.33 1.19e-9 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs561341 0.505 rs28708703 chr17:30386845 C/G cg12193833 chr17:30244370 NA -0.6 -7.88 -0.4 4.8e-14 Hip circumference adjusted for BMI; CRC cis rs10504229 0.728 rs17216187 chr8:58158778 G/T cg21724239 chr8:58056113 NA 0.64 8.48 0.42 8e-16 Developmental language disorder (linguistic errors); CRC trans rs11039798 0.588 rs7483361 chr11:48593786 G/A cg15704280 chr7:45808275 SEPT13 0.65 7.04 0.36 1.13e-11 Axial length; CRC cis rs7394190 0.748 rs3843939 chr10:75578948 T/C cg07699608 chr10:75541558 CHCHD1 0.59 6.01 0.31 5.03e-9 Incident atrial fibrillation; CRC cis rs9921222 1.000 rs10794639 chr16:377367 A/G cg12437481 chr16:420112 MRPL28 -0.56 -8.48 -0.42 7.99e-16 Bone mineral density (spine);Bone mineral density; CRC cis rs9921222 0.597 rs7193109 chr16:413523 T/G cg12437481 chr16:420112 MRPL28 -0.66 -9.91 -0.48 1.97e-20 Bone mineral density (spine);Bone mineral density; CRC cis rs11098499 0.863 rs2291185 chr4:120434833 C/A cg24375607 chr4:120327624 NA 0.49 7.46 0.38 7.86e-13 Corneal astigmatism; CRC cis rs7640424 0.659 rs7639774 chr3:107816216 T/G cg09227934 chr3:107805635 CD47 -0.49 -6.26 -0.33 1.22e-9 Body mass index; CRC cis rs7959452 0.535 rs7135092 chr12:69658330 T/C cg14784868 chr12:69753453 YEATS4 0.74 11.89 0.55 2.31e-27 Blood protein levels; CRC cis rs34172651 0.517 rs200528 chr16:24759131 A/G cg02428538 chr16:24856791 SLC5A11 0.56 6.66 0.34 1.16e-10 Intelligence (multi-trait analysis); CRC cis rs11190604 1.000 rs11190607 chr10:102303614 C/T cg07080220 chr10:102295463 HIF1AN 0.47 5.71 0.3 2.52e-8 Palmitoleic acid (16:1n-7) levels; CRC cis rs2806561 1.000 rs2806558 chr1:23503456 T/C cg19743168 chr1:23544995 NA 0.37 5.85 0.31 1.16e-8 Height; CRC cis rs4481887 0.504 rs12117067 chr1:248363568 A/G cg00666640 chr1:248458726 OR2T12 0.44 7.07 0.36 9.39e-12 Common traits (Other); CRC cis rs12410462 0.681 rs6670816 chr1:227610592 G/T cg04117972 chr1:227635322 NA -0.72 -7.86 -0.4 5.55e-14 Major depressive disorder; CRC cis rs11212617 0.967 rs113995 chr11:108256837 A/T cg01991180 chr11:108092276 ATM;NPAT 0.43 6.49 0.34 3.21e-10 Response to metformin in type 2 diabetes (glycemic); CRC cis rs4665809 0.759 rs62128394 chr2:26364026 T/G cg22920501 chr2:26401640 FAM59B 0.65 7.25 0.37 3.04e-12 Gut microbiome composition (summer); CRC cis rs6964587 0.626 rs4422709 chr7:91510968 A/G cg17063962 chr7:91808500 NA -0.56 -8.84 -0.44 5.89e-17 Breast cancer; CRC cis rs9914988 0.887 rs11650282 chr17:27090741 C/G cg16670446 chr17:27188758 MIR451;MIR144 0.55 8.55 0.43 4.83e-16 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs6460942 0.908 rs967126 chr7:12237300 G/C cg06484146 chr7:12443880 VWDE -0.58 -6.15 -0.32 2.29e-9 Coronary artery disease; CRC cis rs34172651 0.517 rs12927710 chr16:24790282 A/C cg06028605 chr16:24865363 SLC5A11 0.54 8.23 0.41 4.43e-15 Intelligence (multi-trait analysis); CRC cis rs4917300 0.586 rs1352949 chr8:143096253 G/C cg25363559 chr8:143086065 NA -0.34 -6.35 -0.33 6.98e-10 Amyotrophic lateral sclerosis; CRC cis rs6089584 0.819 rs1467593 chr20:60601432 T/G cg13770153 chr20:60521292 NA 0.67 9.93 0.48 1.67e-20 Body mass index; CRC cis rs3772130 0.583 rs7618041 chr3:121566481 G/A cg20356878 chr3:121714668 ILDR1 0.37 6.08 0.32 3.24e-9 Cognitive performance; CRC cis rs6747952 0.866 rs6726348 chr2:239084119 C/T cg17459225 chr2:239074497 NA 0.45 7.81 0.4 7.49e-14 Mean corpuscular hemoglobin concentration; CRC cis rs10791323 0.604 rs2853115 chr11:133707908 C/T cg06766960 chr11:133703094 NA 0.34 5.64 0.3 3.7e-8 Childhood ear infection; CRC cis rs10504229 0.954 rs114134184 chr8:58181969 G/A cg01721255 chr8:58191610 C8orf71 0.49 6.17 0.32 2e-9 Developmental language disorder (linguistic errors); CRC cis rs727505 1.000 rs6971909 chr7:124525517 C/T cg23710748 chr7:124431027 NA -0.68 -12.21 -0.56 1.6e-28 Lewy body disease; CRC cis rs7726839 0.794 rs10053310 chr5:595661 C/G cg09021430 chr5:549028 NA -0.62 -8.35 -0.42 1.86e-15 Obesity-related traits; CRC cis rs4713118 0.869 rs6456802 chr6:27698355 A/G cg03623178 chr6:28175578 NA 0.66 9.34 0.46 1.46e-18 Parkinson's disease; CRC trans rs11165623 0.792 rs6701031 chr1:96975515 C/T cg10631902 chr5:14652156 NA -0.48 -8.8 -0.44 8.16e-17 Hip circumference;Waist circumference; CRC trans rs10504229 1.000 rs949848 chr8:58169125 A/G cg04077850 chr5:125800366 GRAMD3 0.37 6.31 0.33 9.26e-10 Developmental language disorder (linguistic errors); CRC cis rs1580019 0.885 rs4460270 chr7:32496450 C/T cg07520158 chr7:32535189 LSM5;AVL9 0.45 6.48 0.34 3.4e-10 Cognitive ability; CRC cis rs11031096 0.782 rs2284450 chr11:4149214 A/T cg18678763 chr11:4115507 RRM1 -0.51 -8.44 -0.42 1.05e-15 Mean corpuscular volume;Mean corpuscular hemoglobin; CRC cis rs2842992 0.513 rs7759086 chr6:160193853 A/G cg16489826 chr6:160211363 TCP1;MRPL18 0.61 9.29 0.46 2.19e-18 Age-related macular degeneration (geographic atrophy); CRC cis rs10876993 0.728 rs1082503 chr12:58036717 G/A cg15848620 chr12:58087721 OS9 -0.61 -8.29 -0.42 3.02e-15 Celiac disease or Rheumatoid arthritis; CRC cis rs736801 0.607 rs11746555 chr5:131727033 G/A cg02033258 chr5:131593261 PDLIM4 0.34 5.98 0.31 5.71e-9 Breast cancer;Mosquito bite size; CRC cis rs1185460 0.967 rs1786685 chr11:118938957 G/A cg23280166 chr11:118938394 VPS11 0.44 6.68 0.35 1.03e-10 Coronary artery disease; CRC cis rs10888329 0.744 rs7518603 chr1:248349904 A/T cg00666640 chr1:248458726 OR2T12 0.43 6.82 0.35 4.41e-11 Autism spectrum disorder; CRC cis rs3850699 0.683 rs67481356 chr10:104317811 C/A cg04362960 chr10:104952993 NT5C2 0.49 6.05 0.32 3.93e-9 Prostate cancer; CRC cis rs6502050 0.835 rs8081783 chr17:80117388 G/A cg11859384 chr17:80120422 CCDC57 -0.37 -5.98 -0.31 5.86e-9 Life satisfaction; CRC cis rs2652834 0.851 rs11071721 chr15:63350218 T/C cg05507819 chr15:63340323 TPM1 0.46 5.92 0.31 8.02e-9 HDL cholesterol; CRC cis rs7605827 0.866 rs13016989 chr2:15514338 T/A cg19274914 chr2:15703543 NA 0.4 6.06 0.32 3.78e-9 Educational attainment (years of education); CRC cis rs7408868 1.000 rs757475 chr19:15273749 C/T cg14696996 chr19:15285081 NOTCH3 0.97 8.99 0.44 1.99e-17 Pulse pressure; CRC cis rs1799949 1.000 rs12944430 chr17:41330820 C/G cg01879757 chr17:41196368 BRCA1 -0.41 -6.18 -0.32 1.86e-9 Menopause (age at onset); CRC cis rs7647973 0.925 rs4955421 chr3:49218888 G/A cg07636037 chr3:49044803 WDR6 0.64 7.91 0.4 4.06e-14 Menarche (age at onset); CRC cis rs875971 0.522 rs4718285 chr7:65292005 A/G cg02869306 chr7:64672164 INTS4L1 -0.34 -5.8 -0.3 1.59e-8 Aortic root size; CRC cis rs9325144 0.555 rs7977200 chr12:38713745 C/T cg13010199 chr12:38710504 ALG10B 0.42 6.14 0.32 2.31e-9 Morning vs. evening chronotype; CRC cis rs11190604 1.000 rs2495734 chr10:102338686 G/A cg16342193 chr10:102329863 NA -0.38 -6.16 -0.32 2.11e-9 Palmitoleic acid (16:1n-7) levels; CRC cis rs9875589 0.957 rs35485647 chr3:13937937 G/C cg14375111 chr3:14165186 TMEM43;CHCHD4 -0.39 -5.6 -0.3 4.51e-8 Ovarian reserve; CRC trans rs35110281 0.627 rs11701746 chr21:44975137 C/T cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.43 6.84 0.35 3.82e-11 Mean corpuscular volume; CRC cis rs3003334 1 rs3003334 chr1:24199869 G/A cg15997130 chr1:24165203 NA 0.73 10.76 0.51 2.53e-23 Eosinophil percentage of white cells;Eosinophil percentage of granulocytes; CRC cis rs6570726 0.818 rs399516 chr6:145810849 C/A cg13319975 chr6:146136371 FBXO30 -0.38 -5.87 -0.31 1.05e-8 Lobe attachment (rater-scored or self-reported); CRC cis rs12476592 0.602 rs6736029 chr2:63789170 G/A cg10828910 chr2:63850056 LOC388955 0.49 6.11 0.32 2.79e-9 Childhood ear infection; CRC cis rs4132509 0.744 rs10803156 chr1:243917776 G/C cg21452805 chr1:244014465 NA 0.55 5.98 0.31 5.82e-9 RR interval (heart rate); CRC cis rs4713118 0.715 rs200480 chr6:27773664 A/G cg20933634 chr6:27740509 NA 0.46 6.56 0.34 2.08e-10 Parkinson's disease; CRC cis rs9322193 0.884 rs9689702 chr6:150061856 G/A cg04369109 chr6:150039330 LATS1 -0.42 -5.79 -0.3 1.6e-8 Lung cancer; CRC cis rs12893668 0.543 rs12147645 chr14:104100208 T/A cg08213375 chr14:104286397 PPP1R13B 0.41 6.35 0.33 7.33e-10 Reticulocyte count; CRC trans rs6545883 0.931 rs9807965 chr2:61732159 T/C cg11704114 chr12:21509398 SLCO1A2 -0.31 -5.99 -0.31 5.56e-9 Tuberculosis; CRC cis rs6088590 0.965 rs6120730 chr20:33385102 G/C cg08999081 chr20:33150536 PIGU 0.52 8.75 0.43 1.16e-16 Coronary artery disease; CRC cis rs7487075 0.930 rs4076248 chr12:46833605 C/T cg17501823 chr12:47219793 SLC38A4 0.32 5.9 0.31 8.98e-9 Itch intensity from mosquito bite; CRC cis rs951366 0.585 rs72750964 chr1:205675240 C/T cg11965913 chr1:205819406 PM20D1 0.83 12.96 0.58 2.59e-31 Menarche (age at onset); CRC cis rs6429082 0.668 rs291395 chr1:235652049 A/C cg26050004 chr1:235667680 B3GALNT2 -0.66 -10.39 -0.5 4.56e-22 Adiposity; CRC cis rs8014204 0.720 rs34752362 chr14:75232306 G/A cg03030879 chr14:75389066 RPS6KL1 -0.49 -7.9 -0.4 4.25e-14 Caffeine consumption; CRC cis rs5750830 0.649 rs5750811 chr22:39793066 G/T cg25459000 chr22:39777742 SYNGR1 0.33 5.78 0.3 1.74e-8 Intelligence (multi-trait analysis); CRC cis rs736801 0.569 rs12517950 chr5:131731326 A/G cg21138405 chr5:131827807 IRF1 -0.34 -5.83 -0.31 1.36e-8 Breast cancer;Mosquito bite size; CRC cis rs17767392 0.958 rs3825719 chr14:72053097 A/G cg13720639 chr14:72061746 SIPA1L1 -0.56 -7.22 -0.37 3.6e-12 Mitral valve prolapse; CRC cis rs2180341 0.814 rs9401959 chr6:127736464 T/C cg24812749 chr6:127587940 RNF146 0.67 9.02 0.45 1.59e-17 Breast cancer; CRC cis rs8177253 1.000 rs8177240 chr3:133477701 T/G cg16262614 chr3:133464971 TF 0.34 6.05 0.32 4.04e-9 Iron status biomarkers; CRC cis rs12580194 1.000 rs12579030 chr12:55689194 T/C cg19537932 chr12:55886519 OR6C68 -0.6 -8.37 -0.42 1.68e-15 Cancer; CRC trans rs57221529 0.766 rs12521051 chr5:560440 A/G cg25482853 chr8:67687455 SGK3 -1.25 -15.87 -0.66 1.56e-42 Lung disease severity in cystic fibrosis; CRC cis rs7208859 0.614 rs9914534 chr17:29202664 G/A cg13385521 chr17:29058706 SUZ12P 0.65 7.69 0.39 1.7e-13 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs4493873 1.000 rs4493873 chr8:92075643 A/C cg16814680 chr8:91681699 NA 0.41 5.83 0.31 1.3e-8 Migraine - clinic-based; CRC cis rs17539620 0.624 rs12665520 chr6:154835273 C/T cg20019720 chr6:154832845 CNKSR3 0.49 8.29 0.42 2.89e-15 Lipoprotein (a) levels; CRC cis rs2243480 1.000 rs13310597 chr7:65598540 A/G cg12463550 chr7:65579703 CRCP 0.69 6.4 0.33 5.42e-10 Diabetic kidney disease; CRC cis rs826838 0.967 rs1719854 chr12:39127707 G/A cg13010199 chr12:38710504 ALG10B -0.41 -5.84 -0.31 1.27e-8 Heart rate; CRC cis rs7762018 0.607 rs79728466 chr6:170046405 T/C cg24289452 chr6:170231220 NA -0.94 -7.59 -0.39 3.43e-13 Thiazide-induced adverse metabolic effects in hypertensive patients; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg10960135 chr3:121264538 POLQ 0.37 5.98 0.31 5.9e-9 Liver disease severity in Alagille syndrome; CRC cis rs17401966 0.540 rs1536262 chr1:10438687 C/T cg19773385 chr1:10388646 KIF1B -0.46 -7.22 -0.37 3.72e-12 Hepatocellular carcinoma; CRC cis rs17270561 0.609 rs6941933 chr6:25745702 T/C cg17691542 chr6:26056736 HIST1H1C 0.72 9.24 0.45 3.07e-18 Iron status biomarkers; CRC cis rs5769707 0.609 rs739247 chr22:49996657 T/C cg20744362 chr22:50050164 C22orf34 0.34 6.32 0.33 8.57e-10 Monocyte count;Monocyte percentage of white cells; CRC trans rs61931739 0.500 rs9795938 chr12:34587739 C/T cg13010199 chr12:38710504 ALG10B -0.47 -6.66 -0.34 1.15e-10 Morning vs. evening chronotype; CRC cis rs7528419 0.895 rs583104 chr1:109821307 G/T cg00908766 chr1:109817496 CELSR2 0.43 7.92 0.4 3.67e-14 Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease);Myocardial infarction;Lipoprotein-associated phospholipase A2 activity and mass;Lipoprotein-associated phospholipase A2 activity change in response to darapladib treatment in cardiovascular disease;Cholesterol, total;Coronary artery disease; CRC cis rs9311474 0.508 rs7614498 chr3:52618941 A/T cg10802521 chr3:52805072 NEK4 -0.57 -8.95 -0.44 2.67e-17 Electroencephalogram traits; CRC cis rs2302190 0.882 rs9911609 chr17:56673087 T/C cg25885038 chr17:56607967 SEPT4 -0.51 -7.7 -0.39 1.63e-13 Vitamin D levels; CRC cis rs2074585 0.517 rs11635361 chr15:91081791 G/T cg22089800 chr15:90895588 ZNF774 -0.42 -5.87 -0.31 1.04e-8 Basophil percentage of granulocytes;White blood cell count (basophil);Basophil percentage of white cells; CRC cis rs477895 0.713 rs11601024 chr11:63943074 A/G cg05016508 chr11:63871570 FLRT1;MACROD1 0.55 7.02 0.36 1.28e-11 Mean platelet volume; CRC cis rs1348850 0.914 rs12616443 chr2:178315751 A/G cg22681709 chr2:178499509 PDE11A -0.36 -6.7 -0.35 9.23e-11 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs763121 0.853 rs5757213 chr22:39053888 C/T cg06022373 chr22:39101656 GTPBP1 0.78 12.35 0.56 4.64e-29 Menopause (age at onset); CRC cis rs1153858 1.000 rs8032904 chr15:45651309 C/T cg10760299 chr15:45669010 GATM 0.52 8.29 0.42 2.96e-15 Homoarginine levels; CRC cis rs1580019 1.000 rs1580019 chr7:32493169 A/T cg07520158 chr7:32535189 LSM5;AVL9 -0.43 -6.05 -0.32 3.84e-9 Cognitive ability; CRC cis rs28374715 0.733 rs7167706 chr15:41569644 C/A cg18705301 chr15:41695430 NDUFAF1 -1.06 -17.64 -0.7 1.7e-49 Ulcerative colitis; CRC cis rs1552244 0.938 rs67667957 chr3:10167264 G/C cg02579736 chr3:10068473 FANCD2;CIDECP 1.01 13.32 0.59 1.17e-32 Alzheimer's disease; CRC cis rs875971 0.767 rs1643394 chr7:65836094 A/G cg18252515 chr7:66147081 NA -0.4 -5.78 -0.3 1.72e-8 Aortic root size; CRC cis rs6687487 1.000 rs28455953 chr1:23060951 A/G cg05266663 chr1:23061564 EPHB2 -0.65 -5.95 -0.31 6.99e-9 Blood protein levels; CRC cis rs951366 0.622 rs11580015 chr1:205676088 G/C cg07157834 chr1:205819609 PM20D1 0.77 11.27 0.53 3.99e-25 Menarche (age at onset); CRC cis rs6460942 0.908 rs6948654 chr7:12418546 T/A cg10578991 chr7:12443926 VWDE -0.47 -5.66 -0.3 3.24e-8 Coronary artery disease; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg08120044 chr21:42539440 BACE2 0.4 6.41 0.33 5.13e-10 Liver disease severity in Alagille syndrome; CRC cis rs12912251 0.500 rs2643204 chr15:39007171 C/T cg10631289 chr15:39006617 NA -0.49 -5.98 -0.31 5.9e-9 Bipolar disorder;Bipolar disorder or major depressive disorder (combined); CRC cis rs801193 0.805 rs12532355 chr7:66070584 C/G cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.42 -6.22 -0.32 1.54e-9 Aortic root size; CRC cis rs2576037 0.583 rs10070 chr18:44388899 G/A cg19077165 chr18:44547161 KATNAL2 -0.6 -9.88 -0.48 2.52e-20 Personality dimensions; CRC cis rs9487051 0.676 rs1521905 chr6:109594515 T/C cg01475377 chr6:109611718 NA -0.39 -6.89 -0.36 2.77e-11 Reticulocyte fraction of red cells; CRC cis rs7833790 0.777 rs7815272 chr8:82691809 T/G cg17211192 chr8:82754475 SNX16 -0.51 -6.25 -0.33 1.29e-9 Diastolic blood pressure; CRC cis rs4665809 0.590 rs1049987 chr2:26413817 C/T cg22920501 chr2:26401640 FAM59B 0.84 11.74 0.54 7.85e-27 Gut microbiome composition (summer); CRC cis rs4713118 0.513 rs183244 chr6:28031838 C/A cg20615401 chr6:28092323 ZSCAN16 0.47 6.25 0.33 1.28e-9 Parkinson's disease; CRC cis rs58688157 0.705 rs36060383 chr11:598723 A/C cg03909863 chr11:638404 DRD4 -0.53 -7.16 -0.37 5.39e-12 Systemic lupus erythematosus; CRC cis rs12024301 0.557 rs79546878 chr1:183609492 T/C cg11505048 chr1:183622726 RGL1;APOBEC4 0.81 6.83 0.35 4.19e-11 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs9309473 1.000 rs60844734 chr2:73623205 T/A cg20560298 chr2:73613845 ALMS1 -0.47 -5.97 -0.31 6.15e-9 Metabolite levels; CRC cis rs1018836 0.786 rs10956736 chr8:91602067 C/T cg16814680 chr8:91681699 NA -0.68 -10.27 -0.49 1.17e-21 Ejection fraction in Tripanosoma cruzi seropositivity; CRC cis rs597539 0.690 rs7129960 chr11:68622456 A/G cg04772025 chr11:68637568 NA 0.53 8.05 0.41 1.56e-14 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC trans rs4927850 1.000 rs10881564 chr3:195750326 C/T cg16724585 chr3:197361211 NA -0.47 -7.0 -0.36 1.49e-11 Pancreatic cancer; CRC cis rs4713118 0.662 rs149948 chr6:27974817 C/G cg25164649 chr6:28176230 NA 0.63 9.03 0.45 1.43e-17 Parkinson's disease; CRC cis rs6495122 0.501 rs7163636 chr15:75346760 C/T cg09165964 chr15:75287851 SCAMP5 0.5 7.79 0.39 9e-14 Caffeine consumption;Diastolic blood pressure;Coffee consumption; CRC trans rs637571 0.510 rs4930320 chr11:65576788 C/G cg17712092 chr4:129076599 LARP1B -0.54 -8.27 -0.41 3.34e-15 Eosinophil percentage of white cells; CRC cis rs2836974 0.568 rs7282604 chr21:40536910 C/T cg22974920 chr21:40686053 BRWD1 -0.43 -5.93 -0.31 7.62e-9 Cognitive function; CRC cis rs12620999 0.941 rs62183343 chr2:237979163 T/C cg23555395 chr2:238036564 NA 0.54 8.35 0.42 1.91e-15 Systemic lupus erythematosus; CRC cis rs2404602 0.583 rs12438741 chr15:76542114 C/A cg26408565 chr15:76604113 ETFA -0.37 -5.86 -0.31 1.15e-8 Blood metabolite levels; CRC cis rs79387448 0.655 rs17639215 chr2:102953444 G/A cg09003973 chr2:102972529 NA 0.92 10.07 0.49 5.72e-21 Gut microbiota (bacterial taxa); CRC cis rs734999 0.588 rs3748817 chr1:2525665 T/C cg20673091 chr1:2541236 MMEL1 0.36 5.82 0.31 1.43e-8 Ulcerative colitis; CRC cis rs7605827 0.930 rs12692262 chr2:15539084 A/G cg19274914 chr2:15703543 NA 0.39 5.87 0.31 1.09e-8 Educational attainment (years of education); CRC cis rs79839061 0.610 rs34006051 chr4:847445 C/T cg14530993 chr4:882597 GAK 0.82 7.7 0.39 1.64e-13 Intelligence (multi-trait analysis); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg02290575 chr7:100964799 RABL5 0.42 7.05 0.36 1.04e-11 Liver disease severity in Alagille syndrome; CRC cis rs910316 0.737 rs175045 chr14:75475275 A/C cg11812906 chr14:75593930 NEK9 -0.64 -9.29 -0.46 2.24e-18 Height; CRC cis rs758324 0.947 rs1566427 chr5:131191672 G/A cg06307176 chr5:131281290 NA 0.42 6.09 0.32 3.08e-9 Alzheimer's disease in APOE e4- carriers; CRC cis rs9462027 0.628 rs2764208 chr6:34714322 A/G cg07306190 chr6:34760872 UHRF1BP1 -0.33 -5.86 -0.31 1.12e-8 Systemic lupus erythematosus; CRC cis rs9902453 0.791 rs3098950 chr17:27998385 C/T cg26525008 chr17:28256777 EFCAB5;SSH2 0.72 12.14 0.56 2.94e-28 Coffee consumption (cups per day); CRC cis rs1707322 0.929 rs785513 chr1:46538320 T/C cg03146154 chr1:46216737 IPP -0.53 -7.19 -0.37 4.49e-12 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs2439831 0.702 rs7171750 chr15:44025858 G/C cg02155558 chr15:43621948 ADAL;LCMT2 0.69 7.61 0.39 2.96e-13 Lung cancer in ever smokers; CRC cis rs3733585 0.648 rs28513781 chr4:9959334 G/C cg00071950 chr4:10020882 SLC2A9 -0.54 -9.65 -0.47 1.42e-19 Cleft plate (environmental tobacco smoke interaction); CRC trans rs2727020 0.533 rs10839195 chr11:48973460 C/T cg15704280 chr7:45808275 SEPT13 -0.52 -7.51 -0.38 5.7e-13 Coronary artery disease; CRC cis rs7259376 0.807 rs11669254 chr19:22544805 A/G cg02657401 chr19:22469223 NA -0.29 -6.05 -0.32 3.94e-9 Menopause (age at onset); CRC cis rs7208859 0.673 rs12949860 chr17:29223032 A/G cg13385521 chr17:29058706 SUZ12P 0.65 7.62 0.39 2.68e-13 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs7119 0.700 rs60701760 chr15:77888152 G/A cg10437265 chr15:77819839 NA -0.45 -7.96 -0.4 2.86e-14 Type 2 diabetes; CRC cis rs1008375 0.932 rs6449321 chr4:17644472 A/G cg16339924 chr4:17578868 LAP3 0.52 6.82 0.35 4.49e-11 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs11030122 0.702 rs12281293 chr11:3963814 C/T cg18678763 chr11:4115507 RRM1 -0.51 -8.35 -0.42 1.95e-15 Mean platelet volume;Platelet distribution width; CRC trans rs4927850 0.709 rs6765762 chr3:195652851 G/A cg16724585 chr3:197361211 NA -0.5 -6.54 -0.34 2.3e-10 Pancreatic cancer; CRC cis rs12594515 0.967 rs11854477 chr15:45998345 A/C cg22117107 chr15:45993392 NA -0.41 -8.16 -0.41 7.15e-15 Waist circumference;Weight; CRC cis rs860295 0.756 rs7546258 chr1:155698645 T/A cg02153340 chr1:155202674 NA -0.51 -6.25 -0.33 1.25e-9 Body mass index; CRC cis rs7824557 0.564 rs2736294 chr8:11234626 T/C cg20542592 chr8:11973495 FAM66D 0.33 5.8 0.3 1.6e-8 Retinal vascular caliber; CRC cis rs3540 0.533 rs2256097 chr15:90971331 A/T cg22089800 chr15:90895588 ZNF774 0.55 9.08 0.45 1.06e-17 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; CRC trans rs2727020 0.521 rs11039902 chr11:48679467 A/G cg00717180 chr2:96193071 NA -0.37 -6.04 -0.32 4.14e-9 Coronary artery disease; CRC cis rs6684514 1.000 rs12038217 chr1:156248297 C/T cg16558208 chr1:156270281 VHLL 0.59 9.2 0.45 4.08e-18 Mean corpuscular hemoglobin concentration;Glycated hemoglobin levels; CRC cis rs1707322 0.638 rs1707302 chr1:46600917 A/G cg03146154 chr1:46216737 IPP -0.44 -5.71 -0.3 2.48e-8 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs6909279 0.933 rs9479068 chr6:151872448 G/T cg10883421 chr6:151773342 RMND1;C6orf211 -0.38 -5.82 -0.31 1.39e-8 Bone mineral density; CRC cis rs10876993 0.893 rs1678504 chr12:58085498 G/C cg18357645 chr12:58087776 OS9 0.64 8.99 0.44 1.96e-17 Celiac disease or Rheumatoid arthritis; CRC cis rs7715806 0.500 rs17563700 chr5:74986045 A/G cg19683494 chr5:74908142 NA 0.59 6.58 0.34 1.81e-10 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs6662572 0.737 rs4434876 chr1:46270129 T/C cg03123370 chr1:45965343 CCDC163P;MMACHC -0.47 -6.08 -0.32 3.36e-9 Blood protein levels; CRC trans rs2832077 0.943 rs11701777 chr21:30155828 T/C cg14791747 chr16:20752902 THUMPD1 0.55 6.83 0.35 4.09e-11 Cognitive test performance; CRC cis rs7927771 0.929 rs66749409 chr11:47568074 C/T cg05585544 chr11:47624801 NA -0.62 -11.41 -0.53 1.22e-25 Subjective well-being; CRC cis rs6545883 0.965 rs6545872 chr2:61724568 G/A cg15711740 chr2:61764176 XPO1 -0.51 -7.01 -0.36 1.35e-11 Tuberculosis; CRC cis rs9611565 0.643 rs202634 chr22:41809623 A/G cg06634786 chr22:41940651 POLR3H 0.66 7.53 0.38 4.88e-13 Vitiligo; CRC cis rs7677751 0.767 rs890204 chr4:55064439 C/G cg00691999 chr4:55094011 PDGFRA 0.42 5.98 0.31 5.94e-9 Corneal astigmatism; CRC cis rs28386778 0.863 rs2727355 chr17:61931790 C/T cg06873352 chr17:61820015 STRADA 0.73 13.62 0.6 8.27e-34 Prudent dietary pattern; CRC cis rs7945705 0.818 rs2653613 chr11:8879105 C/T cg00186954 chr11:8933980 ST5;C11orf17 -0.49 -8.26 -0.41 3.56e-15 Hemoglobin concentration; CRC cis rs6598955 0.671 rs12139514 chr1:26575939 G/A cg04990556 chr1:26633338 UBXN11 0.56 6.02 0.32 4.53e-9 Obesity-related traits; CRC cis rs7705042 0.865 rs7733850 chr5:141515564 C/T cg07392085 chr5:141489673 NDFIP1 0.45 7.26 0.37 2.75e-12 Asthma; CRC trans rs9858542 1.000 rs2172252 chr3:49678307 A/T cg21659725 chr3:3221576 CRBN -0.69 -9.08 -0.45 1.06e-17 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs7258465 0.931 rs11673604 chr19:18540988 T/C cg06462663 chr19:18546047 ISYNA1 0.5 7.33 0.37 1.82e-12 Breast cancer; CRC cis rs3736485 0.966 rs11633713 chr15:51908052 C/T cg08986416 chr15:51914746 DMXL2 -0.45 -6.45 -0.34 3.97e-10 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC trans rs6951245 1.000 rs79683221 chr7:1096139 A/G cg13565492 chr6:43139072 SRF -0.71 -7.38 -0.38 1.32e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs12044355 0.929 rs11122323 chr1:231848933 G/A cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX 0.45 6.07 0.32 3.43e-9 Alzheimer's disease; CRC cis rs8031584 0.541 rs1983459 chr15:31208749 C/T cg08109568 chr15:31115862 NA -0.4 -6.53 -0.34 2.5e-10 Huntington's disease progression; CRC cis rs834811 0.583 rs12539683 chr7:135891486 A/T cg01726295 chr7:135938950 NA 0.35 6.01 0.31 5e-9 Post-traumatic stress disorder; CRC cis rs12477438 0.798 rs7606635 chr2:99644782 G/A cg14399236 chr2:99771627 LIPT1;TSGA10 -0.6 -8.2 -0.41 5.41e-15 Chronic sinus infection; CRC cis rs9303401 0.614 rs12950028 chr17:56510140 A/G cg10487724 chr17:56770010 TEX14;RAD51C 0.75 9.27 0.45 2.56e-18 Cognitive test performance; CRC cis rs3820928 0.904 rs10933161 chr2:227764872 A/G cg11843606 chr2:227700838 RHBDD1 -0.4 -5.82 -0.31 1.43e-8 Pulmonary function; CRC cis rs9303280 0.901 rs8067378 chr17:38051348 A/G cg00129232 chr17:37814104 STARD3 -0.44 -6.91 -0.36 2.58e-11 Self-reported allergy; CRC cis rs200986 1 rs200986 chr6:27824766 G/C cg20933634 chr6:27740509 NA 0.5 7.17 0.37 4.9e-12 Autism spectrum disorder or schizophrenia; CRC cis rs12477438 0.520 rs4850897 chr2:99768419 A/G cg14399236 chr2:99771627 LIPT1;TSGA10 0.73 12.05 0.55 6.15e-28 Chronic sinus infection; CRC cis rs9926296 0.605 rs6500449 chr16:89856393 T/C cg27121462 chr16:89883253 FANCA 0.57 9.1 0.45 8.82e-18 Vitiligo; CRC cis rs72945132 0.882 rs7940090 chr11:70227824 C/G cg00319359 chr11:70116639 PPFIA1 0.55 6.0 0.31 5.18e-9 Coronary artery disease; CRC cis rs1124376 1.000 rs61457790 chr3:20136186 G/A cg05072819 chr3:20081367 KAT2B 0.54 6.2 0.32 1.66e-9 Bipolar disorder and schizophrenia; CRC cis rs28655083 0.956 rs4088757 chr16:77071545 A/G cg01753188 chr16:77233325 SYCE1L;MON1B 0.5 7.12 0.37 6.61e-12 Lobe attachment (rater-scored or self-reported); CRC cis rs12477438 0.501 rs12995473 chr2:99764884 G/T cg14399236 chr2:99771627 LIPT1;TSGA10 0.79 13.62 0.6 8.2e-34 Chronic sinus infection; CRC cis rs9549367 0.713 rs9549681 chr13:113829873 T/C cg18105134 chr13:113819100 PROZ -0.85 -12.49 -0.57 1.49e-29 Platelet distribution width; CRC cis rs17023223 0.537 rs17023171 chr1:119593268 A/C cg05756136 chr1:119680316 WARS2 -0.44 -5.86 -0.31 1.15e-8 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for BMI in active individuals; CRC cis rs62064224 0.589 rs2285428 chr17:30820176 C/T cg18200150 chr17:30822561 MYO1D -0.48 -9.25 -0.45 2.91e-18 Schizophrenia; CRC cis rs7258465 1.000 rs34171762 chr19:18559410 G/A cg06462663 chr19:18546047 ISYNA1 0.49 7.31 0.37 1.98e-12 Breast cancer; CRC trans rs1814175 0.592 rs1794161 chr11:49898825 A/C cg11707556 chr5:10655725 ANKRD33B -0.52 -9.98 -0.48 1.12e-20 Height; CRC cis rs6121246 0.821 rs6058448 chr20:30332396 C/T cg18721089 chr20:30220636 NA -0.36 -5.86 -0.31 1.12e-8 Mean corpuscular hemoglobin; CRC cis rs7264396 0.508 rs6060739 chr20:34567592 C/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.55 -8.77 -0.44 9.46e-17 Total cholesterol levels; CRC cis rs3771570 0.901 rs35256094 chr2:242439938 A/C cg21155796 chr2:242212141 HDLBP 0.64 6.83 0.35 4.08e-11 Prostate cancer; CRC trans rs6076960 0.684 rs6054049 chr20:6254909 A/G cg17788362 chr6:86352627 SYNCRIP -0.47 -6.41 -0.33 5.19e-10 Smooth-surface caries; CRC cis rs4862750 0.794 rs7692427 chr4:187901727 G/A cg11301795 chr4:187892539 NA -0.87 -20.32 -0.75 4.87e-60 Lobe attachment (rater-scored or self-reported); CRC cis rs9611565 0.649 rs202655 chr22:41841564 G/C cg06634786 chr22:41940651 POLR3H 0.55 6.72 0.35 7.98e-11 Vitiligo; CRC cis rs12134245 0.776 rs12137878 chr1:91973210 G/T cg07090678 chr1:91966139 CDC7 0.44 7.15 0.37 5.48e-12 Breast cancer; CRC cis rs523522 0.962 rs4767902 chr12:120910004 C/T cg27279351 chr12:120934652 DYNLL1 0.79 11.41 0.53 1.2e-25 High light scatter reticulocyte count; CRC cis rs11122272 0.735 rs2355873 chr1:231477442 A/G cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.47 -6.85 -0.35 3.75e-11 Hemoglobin concentration; CRC cis rs9292777 0.897 rs1445004 chr5:40414419 C/T cg09067459 chr5:40385259 NA 0.51 8.76 0.43 1.05e-16 Crohn's disease;Multiple sclerosis; CRC cis rs10540 1.000 rs61877775 chr11:521462 C/T cg15790184 chr11:494944 RNH1 0.66 6.4 0.33 5.31e-10 Body mass index; CRC cis rs11577318 0.853 rs11803933 chr1:26629465 G/C cg04990556 chr1:26633338 UBXN11 -0.48 -6.15 -0.32 2.31e-9 Granulocyte percentage of myeloid white cells; CRC cis rs1448094 0.817 rs10863121 chr12:86343834 A/C cg25456477 chr12:86230367 RASSF9 -0.34 -5.87 -0.31 1.04e-8 Major depressive disorder; CRC cis rs2976388 0.578 rs3758081 chr8:143824373 A/G cg15511327 chr8:143859410 LYNX1 -0.4 -6.19 -0.32 1.81e-9 Urinary tract infection frequency; CRC cis rs4808199 0.948 rs2301671 chr19:19466269 C/T cg03709012 chr19:19516395 GATAD2A 0.88 10.79 0.51 1.93e-23 Nonalcoholic fatty liver disease; CRC cis rs853679 0.517 rs9295761 chr6:28147987 A/G cg12963246 chr6:28129442 ZNF389 0.5 5.76 0.3 1.88e-8 Depression; CRC cis rs9443645 0.901 rs9352686 chr6:79758223 T/G cg05283184 chr6:79620031 NA -0.6 -9.61 -0.47 1.9e-19 Intelligence (multi-trait analysis); CRC cis rs34172651 0.917 rs2343606 chr16:24793741 C/T cg06028605 chr16:24865363 SLC5A11 0.44 7.87 0.4 5.09e-14 Intelligence (multi-trait analysis); CRC cis rs1008375 1.000 rs1121089 chr4:17676476 C/A cg04450456 chr4:17643702 FAM184B 0.39 6.22 0.32 1.53e-9 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs8072100 0.905 rs9901869 chr17:45575206 G/A cg25173405 chr17:45401733 C17orf57 -0.45 -6.89 -0.36 2.87e-11 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs10493773 0.609 rs11161664 chr1:86185379 C/T cg17807903 chr1:86174739 ZNHIT6 -0.64 -17.41 -0.69 1.47e-48 Urate levels in overweight individuals; CRC cis rs853679 0.517 rs12174753 chr6:28042465 C/G cg23161317 chr6:28129485 ZNF389 0.53 6.55 0.34 2.21e-10 Depression; CRC trans rs7615952 0.512 rs2979334 chr3:125358824 G/A cg16558177 chr4:4109446 NA -0.62 -8.74 -0.43 1.23e-16 Blood pressure (smoking interaction); CRC cis rs12476592 0.602 rs11125977 chr2:63809549 C/T cg10828910 chr2:63850056 LOC388955 -0.46 -5.73 -0.3 2.22e-8 Childhood ear infection; CRC cis rs2463822 0.920 rs72923207 chr11:62117959 A/G cg06239285 chr11:62104954 ASRGL1 -1.02 -10.27 -0.49 1.16e-21 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs6662572 0.737 rs4573476 chr1:46346721 T/A cg03123370 chr1:45965343 CCDC163P;MMACHC 0.47 5.78 0.3 1.77e-8 Blood protein levels; CRC cis rs7923609 0.967 rs2393986 chr10:65320006 A/T cg08743896 chr10:65200160 JMJD1C -0.4 -5.72 -0.3 2.42e-8 Educational attainment;Liver enzyme levels (alkaline phosphatase); CRC cis rs10256972 0.521 rs10280960 chr7:1103697 A/G cg27094323 chr7:1216898 NA -0.33 -5.61 -0.3 4.34e-8 Longevity;Endometriosis; CRC cis rs9467711 0.720 rs35627490 chr6:26462104 C/T cg08501292 chr6:25962987 TRIM38 0.85 5.77 0.3 1.79e-8 Autism spectrum disorder or schizophrenia; CRC cis rs10504229 0.593 rs79615400 chr8:57988740 C/T cg22535103 chr8:58192502 C8orf71 -0.63 -6.63 -0.34 1.38e-10 Developmental language disorder (linguistic errors); CRC cis rs9388451 0.805 rs1028481 chr6:126106573 G/T cg05901451 chr6:126070800 HEY2 -0.65 -11.17 -0.52 8.86e-25 Brugada syndrome; CRC cis rs4727027 0.745 rs10952801 chr7:148864757 T/C cg23583168 chr7:148888333 NA -0.92 -16.19 -0.67 9.15e-44 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC cis rs9768139 0.733 rs35016950 chr7:158118710 C/A cg24154853 chr7:158122151 PTPRN2 0.62 10.19 0.49 2.17e-21 Calcium levels; CRC cis rs7937682 0.632 rs10789850 chr11:111750829 C/T cg09085632 chr11:111637200 PPP2R1B 0.95 15.21 0.64 6.22e-40 Primary sclerosing cholangitis; CRC cis rs6582630 0.537 rs10785436 chr12:38461040 G/C cg26384229 chr12:38710491 ALG10B 0.7 10.01 0.48 9.23e-21 Drug-induced liver injury (flucloxacillin); CRC cis rs9549367 0.737 rs9549712 chr13:113902355 G/A cg18105134 chr13:113819100 PROZ -0.74 -10.65 -0.51 6.16e-23 Platelet distribution width; CRC cis rs67340775 0.541 rs200966 chr6:27862152 T/C cg08798685 chr6:27730294 NA -0.58 -6.44 -0.33 4.18e-10 Lung cancer in ever smokers; CRC cis rs6663390 0.831 rs3754171 chr1:208086939 T/C cg03990033 chr1:208084030 CD34 0.5 6.89 0.35 2.9100000000000002e-11 Facial morphology (factor 18); CRC cis rs6504622 0.721 rs8077021 chr17:45139303 T/C cg16759221 chr17:45003025 GOSR2 0.45 6.93 0.36 2.23e-11 Orofacial clefts; CRC cis rs10971721 0.908 rs10971728 chr9:33834633 G/T cg13495928 chr9:33750294 PRSS3 0.55 5.93 0.31 7.7e-9 Body mass index; CRC trans rs10506458 1.000 rs12425932 chr12:63410497 C/A cg22491629 chr6:157744540 C6orf35 -0.71 -8.54 -0.43 4.91e-16 Hemostatic factors and hematological phenotypes; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg10494556 chr7:1199936 ZFAND2A 0.36 6.07 0.32 3.61e-9 Liver disease severity in Alagille syndrome; CRC cis rs2836974 0.899 rs8127087 chr21:40544502 C/T cg11644478 chr21:40555479 PSMG1 0.82 12.67 0.57 3.15e-30 Cognitive function; CRC cis rs6964587 0.869 rs6964050 chr7:91482418 C/T cg17063962 chr7:91808500 NA -0.76 -12.99 -0.58 2.03e-31 Breast cancer; CRC cis rs4727027 0.901 rs4727018 chr7:148822247 G/C cg23583168 chr7:148888333 NA -0.84 -13.92 -0.61 6.1e-35 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg21908638 chr3:101497982 FAM55C 0.38 6.2 0.32 1.73e-9 Liver disease severity in Alagille syndrome; CRC trans rs1005277 0.579 rs2103938 chr10:38493998 T/G cg11292332 chr7:45801988 SEPT13 -0.39 -7.04 -0.36 1.12e-11 Extrinsic epigenetic age acceleration; CRC cis rs4713118 0.869 rs6456802 chr6:27698355 A/G cg12273811 chr6:28175739 NA 0.53 7.64 0.39 2.4e-13 Parkinson's disease; CRC cis rs10504229 0.683 rs2291765 chr8:58142874 C/T cg05313129 chr8:58192883 C8orf71 -0.4 -5.85 -0.31 1.16e-8 Developmental language disorder (linguistic errors); CRC cis rs4478858 0.684 rs1546375 chr1:31765968 C/T cg00250761 chr1:31883323 NA -0.4 -7.69 -0.39 1.76e-13 Alcohol dependence; CRC trans rs66573146 0.831 rs1048009 chr4:6988677 G/A cg07817883 chr1:32538562 TMEM39B 1.12 11.82 0.55 4.19e-27 Granulocyte percentage of myeloid white cells; CRC cis rs12580194 0.593 rs61957946 chr12:55755778 T/C cg23425280 chr12:56401806 NA 0.47 5.78 0.3 1.76e-8 Cancer; CRC cis rs172166 0.637 rs1225592 chr6:28150242 G/A cg12172441 chr6:28176163 NA 0.59 8.41 0.42 1.23e-15 Cardiac Troponin-T levels; CRC cis rs2739330 0.760 rs5751761 chr22:24243736 A/G cg04234412 chr22:24373322 LOC391322 0.75 12.25 0.56 1.12e-28 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs782590 0.574 rs12991445 chr2:55675939 C/T cg18811423 chr2:55921094 PNPT1 0.6 8.76 0.43 1.03e-16 Metabolic syndrome; CRC cis rs1707322 0.827 rs12125508 chr1:46246010 A/G cg06784218 chr1:46089804 CCDC17 0.6 10.93 0.52 6.45e-24 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs9393692 0.905 rs2393592 chr6:26285560 A/G cg13736514 chr6:26305472 NA -0.63 -11.86 -0.55 2.88e-27 Educational attainment; CRC cis rs7107174 1.000 rs10793302 chr11:78040961 C/T cg02023728 chr11:77925099 USP35 0.49 8.26 0.41 3.48e-15 Testicular germ cell tumor; CRC trans rs7088591 0.558 rs57910753 chr10:59819531 T/C cg21239940 chr8:68870412 PREX2 0.54 6.01 0.31 4.93e-9 Blood pressure; CRC cis rs6714710 0.535 rs3192177 chr2:98354511 G/A cg26665480 chr2:98280029 ACTR1B 0.51 6.8 0.35 4.95e-11 Posterior cortical atrophy and Alzheimer's disease; CRC cis rs4077515 0.504 rs7628 chr9:139318071 A/G cg14019695 chr9:139328340 INPP5E 0.38 5.8 0.3 1.57e-8 Ulcerative colitis;IgA nephropathy;Inflammatory bowel disease;Crohn's disease; CRC cis rs477895 0.713 rs35095324 chr11:63948412 G/A cg23719950 chr11:63933701 MACROD1 -0.66 -8.53 -0.43 5.51e-16 Mean platelet volume; CRC cis rs10504229 0.728 rs17215851 chr8:58154160 A/C cg02290350 chr8:58132656 NA -0.51 -6.57 -0.34 1.98e-10 Developmental language disorder (linguistic errors); CRC cis rs6540559 1.000 rs742214 chr1:209960925 T/C cg22029157 chr1:209979665 IRF6 0.7 9.98 0.48 1.16e-20 Cleft lip with or without cleft palate; CRC cis rs651907 0.557 rs2318090 chr3:101474933 A/G cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.63 8.73 0.43 1.3e-16 Colorectal cancer; CRC cis rs1552244 0.554 rs6800204 chr3:9995404 A/G cg02579736 chr3:10068473 FANCD2;CIDECP 0.64 9.07 0.45 1.07e-17 Alzheimer's disease; CRC cis rs9372498 0.536 rs9489450 chr6:118904385 G/A cg01339444 chr6:118972232 C6orf204 0.55 6.2 0.32 1.69e-9 Diastolic blood pressure; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg26486702 chr1:161129448 USP21 0.46 6.73 0.35 7.69e-11 Intelligence (multi-trait analysis); CRC cis rs1018836 0.923 rs12545279 chr8:91636373 C/G cg16814680 chr8:91681699 NA -0.73 -11.27 -0.53 3.95e-25 Ejection fraction in Tripanosoma cruzi seropositivity; CRC cis rs12950390 0.853 rs11655112 chr17:45856563 T/C cg24803719 chr17:45855879 NA -0.32 -7.01 -0.36 1.32e-11 IgG glycosylation; CRC trans rs2727020 0.553 rs10839295 chr11:49527345 A/C cg11707556 chr5:10655725 ANKRD33B -0.4 -7.5 -0.38 5.84e-13 Coronary artery disease; CRC cis rs2153535 0.541 rs6908504 chr6:8456778 A/G cg07606381 chr6:8435919 SLC35B3 0.69 11.15 0.52 1.04e-24 Motion sickness; CRC trans rs4785204 1.000 rs4785202 chr16:50095995 C/T cg07960154 chr17:37760198 NEUROD2 -0.64 -6.03 -0.32 4.47e-9 Esophageal cancer (squamous cell); CRC cis rs600626 0.636 rs10899110 chr11:75452342 C/G cg24262691 chr11:75473276 NA 0.55 7.61 0.39 2.96e-13 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CRC cis rs1712517 0.873 rs7913461 chr10:105001325 A/G cg05636881 chr10:105038444 INA 0.45 7.78 0.39 9.63e-14 Migraine; CRC cis rs7705042 0.865 rs6580229 chr5:141510754 A/G cg07392085 chr5:141489673 NDFIP1 0.46 7.23 0.37 3.48e-12 Asthma; CRC cis rs6582630 0.504 rs4882367 chr12:38330878 A/T cg26384229 chr12:38710491 ALG10B -0.51 -7.44 -0.38 8.9e-13 Drug-induced liver injury (flucloxacillin); CRC cis rs10504229 1.000 rs60231757 chr8:58169937 T/C cg01721255 chr8:58191610 C8orf71 0.49 6.17 0.32 2e-9 Developmental language disorder (linguistic errors); CRC cis rs9733 0.519 rs2184833 chr1:150675483 C/T cg17724175 chr1:150552817 MCL1 0.61 9.88 0.48 2.49e-20 Tonsillectomy; CRC cis rs73206853 0.841 rs28404862 chr12:110850241 C/G cg12870014 chr12:110450643 ANKRD13A 0.76 8.38 0.42 1.53e-15 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC cis rs10256972 0.732 rs1574108 chr7:1105805 T/C cg04025307 chr7:1156635 C7orf50 0.56 8.48 0.42 7.76e-16 Longevity;Endometriosis; CRC cis rs10946940 0.965 rs4713112 chr6:27516833 G/T cg21251018 chr6:28226885 NKAPL -0.41 -6.31 -0.33 8.88e-10 Systemic lupus erythematosus; CRC cis rs3096299 0.692 rs4785565 chr16:89515759 T/C cg01788221 chr16:89496183 ANKRD11 -0.39 -5.94 -0.31 7.22e-9 Multiple myeloma (IgH translocation); CRC cis rs941873 0.868 rs2181080 chr10:81121960 A/G cg08514558 chr10:81106712 PPIF 0.36 5.77 0.3 1.88e-8 Height; CRC cis rs13064411 0.735 rs9875025 chr3:113147552 T/C cg18753928 chr3:113234510 CCDC52 -0.54 -7.54 -0.38 4.48e-13 Response to simvastatin treatment (PCSK9 protein level change); CRC cis rs1552244 0.938 rs9873794 chr3:10074153 T/G cg10729496 chr3:10149963 C3orf24 0.49 6.52 0.34 2.67e-10 Alzheimer's disease; CRC cis rs7089973 0.624 rs10885613 chr10:116589400 G/A cg23260525 chr10:116636907 FAM160B1 0.35 8.07 0.41 1.34e-14 Bipolar disorder or attention deficit hyperactivity disorder; CRC cis rs6570726 0.811 rs375873 chr6:145812371 G/T cg05347473 chr6:146136440 FBXO30 0.37 5.81 0.31 1.48e-8 Lobe attachment (rater-scored or self-reported); CRC cis rs1448094 0.512 rs11832992 chr12:86240790 T/C cg19622623 chr12:86230825 RASSF9 -0.41 -6.73 -0.35 7.69e-11 Major depressive disorder; CRC cis rs9768139 0.733 rs56205111 chr7:158121055 T/C cg23298862 chr7:158159286 PTPRN2 0.38 5.99 0.31 5.49e-9 Calcium levels; CRC cis rs910316 0.967 rs175451 chr14:75589729 C/T cg08847533 chr14:75593920 NEK9 -0.89 -16.43 -0.67 1.01e-44 Height; CRC cis rs853679 0.517 rs9357061 chr6:28051772 A/G cg02631126 chr6:28058918 ZSCAN12L1 0.29 6.09 0.32 3.1e-9 Depression; CRC cis rs1475911 1.000 rs2839465 chr21:43511232 C/T cg14562523 chr21:43528734 C21orf128;UMODL1 -0.46 -6.03 -0.32 4.3e-9 IgG glycosylation; CRC cis rs394563 0.517 rs385303 chr6:149779064 C/T cg07828024 chr6:149772892 ZC3H12D -0.44 -7.15 -0.37 5.79e-12 Dupuytren's disease; CRC cis rs17092148 0.887 rs2068474 chr20:33231079 A/G cg08999081 chr20:33150536 PIGU 0.5 6.16 0.32 2.1e-9 Neuroticism; CRC cis rs13217239 0.646 rs9379956 chr6:27033735 T/C cg12292205 chr6:26970375 C6orf41 -0.52 -8.53 -0.43 5.27e-16 Schizophrenia; CRC trans rs17570583 1.000 rs17570583 chr5:171559531 A/G cg08920628 chr10:48354911 ZNF488 0.6 5.99 0.31 5.56e-9 Migraine - clinic-based; CRC cis rs344364 0.511 rs1657133 chr16:1950300 A/G cg03013636 chr16:1946785 NA 0.58 7.08 0.36 8.69e-12 Glomerular filtration rate in chronic kidney disease; CRC trans rs10242455 0.702 rs76702117 chr7:98916779 A/G cg09045935 chr12:6379348 NA 0.98 7.27 0.37 2.66e-12 Blood metabolite levels; CRC cis rs6761276 0.899 rs12466799 chr2:113835999 T/C cg09040174 chr2:113837401 NA 0.64 10.17 0.49 2.63e-21 Protein quantitative trait loci; CRC cis rs10752881 0.935 rs10797834 chr1:183048749 T/G ch.1.3577855R chr1:183094577 LAMC1 0.82 14.22 0.62 4.34e-36 Colorectal cancer; CRC trans rs7615952 0.546 rs2979307 chr3:125309574 C/T cg02007433 chr3:129722099 NA 0.49 6.24 0.33 1.35e-9 Blood pressure (smoking interaction); CRC cis rs1552244 1.000 rs56394721 chr3:10150795 A/G cg02579736 chr3:10068473 FANCD2;CIDECP 1.06 14.07 0.61 1.53e-35 Alzheimer's disease; CRC cis rs3096299 0.719 rs2353581 chr16:89518908 T/C cg08392591 chr16:89556376 ANKRD11 0.43 5.89 0.31 9.34e-9 Multiple myeloma (IgH translocation); CRC cis rs559928 0.606 rs56207008 chr11:63883215 C/T cg05555928 chr11:63887634 MACROD1 -0.54 -5.72 -0.3 2.38e-8 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; CRC cis rs4332037 0.539 rs34809719 chr7:2028968 G/T cg23422044 chr7:1970798 MAD1L1 -0.62 -7.43 -0.38 9.36e-13 Bipolar disorder; CRC cis rs853679 0.550 rs6901017 chr6:28152583 T/C cg12273811 chr6:28175739 NA 0.75 10.18 0.49 2.5e-21 Depression; CRC trans rs9329221 0.592 rs7832708 chr8:10190040 C/T cg08975724 chr8:8085496 FLJ10661 0.44 6.83 0.35 4.07e-11 Neuroticism; CRC trans rs8002861 0.754 rs4053664 chr13:44429172 A/C cg17145862 chr1:211918768 LPGAT1 0.72 14.34 0.62 1.46e-36 Leprosy; CRC cis rs17023223 0.537 rs2765532 chr1:119591546 T/C cg05756136 chr1:119680316 WARS2 -0.46 -6.26 -0.33 1.18e-9 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for BMI in active individuals; CRC cis rs7312933 0.670 rs10880269 chr12:42606135 C/T cg11827402 chr12:42719852 PPHLN1;ZCRB1 0.65 8.94 0.44 2.83e-17 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CRC cis rs7781557 0.640 rs6955064 chr7:102579571 T/C cg18108683 chr7:102477205 FBXL13 -0.49 -5.69 -0.3 2.86e-8 Colorectal adenoma (advanced); CRC cis rs72634258 0.945 rs1883679 chr1:8100451 T/G cg00042356 chr1:8021962 PARK7 0.66 7.21 0.37 3.94e-12 Inflammatory bowel disease; CRC cis rs2274471 0.660 rs10974948 chr9:5075255 C/T cg03390472 chr9:5043263 JAK2 -0.58 -6.41 -0.33 4.97e-10 Crohn's disease; CRC cis rs10504229 0.679 rs72649109 chr8:58031274 A/T cg11062466 chr8:58055876 NA 0.55 6.88 0.35 2.97e-11 Developmental language disorder (linguistic errors); CRC cis rs9325144 0.600 rs12424410 chr12:38758035 A/T cg26384229 chr12:38710491 ALG10B -0.53 -7.63 -0.39 2.54e-13 Morning vs. evening chronotype; CRC cis rs12912251 0.591 rs2624272 chr15:39003409 A/G cg10631289 chr15:39006617 NA -0.5 -6.19 -0.32 1.76e-9 Bipolar disorder;Bipolar disorder or major depressive disorder (combined); CRC cis rs9487051 0.768 rs386696 chr6:109520166 G/A cg21918786 chr6:109611834 NA -0.33 -5.73 -0.3 2.3e-8 Reticulocyte fraction of red cells; CRC cis rs9660992 0.674 rs1151785 chr1:205232299 C/T cg21643547 chr1:205240462 TMCC2 -0.46 -7.24 -0.37 3.14e-12 Mean corpuscular volume;Mean platelet volume; CRC cis rs6534441 0.824 rs6836758 chr4:125458226 G/A cg21609808 chr4:125404261 NA 0.38 5.75 0.3 2.07e-8 Major depressive disorder; CRC cis rs765787 0.530 rs1706837 chr15:45519036 A/G cg24006582 chr15:45444508 DUOX1 -0.58 -8.78 -0.44 9.23e-17 Uric acid levels; CRC cis rs600806 0.888 rs4970749 chr1:109873573 G/A cg23032129 chr1:109941072 SORT1 -0.28 -6.04 -0.32 4.16e-9 Intelligence (multi-trait analysis); CRC cis rs6951245 1.000 rs79765398 chr7:1073764 A/G cg21664854 chr7:1097933 C7orf50;GPR146 0.79 8.9 0.44 3.69e-17 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs6815814 0.950 rs45588337 chr4:38807328 A/G cg06935464 chr4:38784597 TLR10 0.57 5.97 0.31 6.19e-9 Breast cancer; CRC cis rs9768139 0.733 rs13309363 chr7:158122179 C/A cg06219351 chr7:158114137 PTPRN2 -0.52 -7.86 -0.4 5.7e-14 Calcium levels; CRC cis rs6545883 0.507 rs12617371 chr2:61569134 A/G cg10580144 chr2:61372316 C2orf74 -0.34 -7.55 -0.38 4.37e-13 Tuberculosis; CRC cis rs6831352 0.879 rs56272995 chr4:100060882 A/G cg13256891 chr4:100009986 ADH5 -0.65 -8.82 -0.44 6.89e-17 Alcohol dependence; CRC cis rs1322512 1.000 rs2250514 chr6:153010920 C/T cg03415253 chr6:152958462 SYNE1 0.39 5.86 0.31 1.1e-8 Tonometry; CRC cis rs4713118 0.869 rs9295742 chr6:27702832 G/A cg21251018 chr6:28226885 NKAPL 0.38 5.71 0.3 2.5e-8 Parkinson's disease; CRC cis rs4727027 0.933 rs62505074 chr7:148834780 C/T cg12479418 chr7:148823350 ZNF425;ZNF398 0.42 5.74 0.3 2.14e-8 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC cis rs6964587 0.626 rs10225241 chr7:91524940 A/G cg17063962 chr7:91808500 NA -0.59 -9.33 -0.46 1.59e-18 Breast cancer; CRC cis rs3859192 0.599 rs2227321 chr17:38171294 G/C cg17344932 chr17:38183730 MED24;SNORD124 0.86 16.76 0.68 5.07e-46 White blood cell count; CRC cis rs4478858 0.735 rs4494186 chr1:31857847 G/A cg00250761 chr1:31883323 NA 0.41 7.74 0.39 1.25e-13 Alcohol dependence; CRC cis rs796364 0.950 rs56155997 chr2:200768491 C/T cg12253985 chr2:200820533 C2orf60;C2orf47 -0.66 -6.35 -0.33 7.11e-10 Schizophrenia; CRC cis rs28386778 0.897 rs2727326 chr17:61923016 G/A cg06873352 chr17:61820015 STRADA 0.76 14.24 0.62 3.62e-36 Prudent dietary pattern; CRC cis rs763121 0.962 rs2071887 chr22:38879010 A/T cg06022373 chr22:39101656 GTPBP1 0.71 11.08 0.52 1.87e-24 Menopause (age at onset); CRC cis rs514406 0.505 rs437954 chr1:53173321 C/G cg25767906 chr1:53392781 SCP2 -0.39 -6.2 -0.32 1.72e-9 Monocyte count; CRC cis rs10771431 0.597 rs10843142 chr12:9357502 A/G cg08997352 chr12:9597637 DDX12 -0.45 -6.62 -0.34 1.47e-10 Breast size; CRC cis rs4925114 0.568 rs4925109 chr17:17661802 A/G cg16928487 chr17:17741425 SREBF1 0.55 9.89 0.48 2.29e-20 Body mass index; CRC cis rs2932538 0.922 rs6659677 chr1:113087076 G/C cg22162597 chr1:113214053 CAPZA1 0.7 9.9 0.48 2.09e-20 Systolic blood pressure;Diastolic blood pressure;Hypertension;Blood pressure; CRC cis rs1215050 0.740 rs6855827 chr4:99065706 G/A cg05340658 chr4:99064831 C4orf37 0.49 7.51 0.38 5.6e-13 Waist-to-hip ratio adjusted for body mass index; CRC cis rs11122272 0.735 rs2250734 chr1:231485958 G/A cg06096015 chr1:231504339 EGLN1 0.38 5.88 0.31 1.01e-8 Hemoglobin concentration; CRC cis rs5769765 0.671 rs138832 chr22:50178082 A/G cg02269571 chr22:50332266 NA -0.59 -7.67 -0.39 1.96e-13 Schizophrenia; CRC trans rs10504229 0.906 rs17805439 chr8:58172400 T/C cg04077850 chr5:125800366 GRAMD3 0.37 6.27 0.33 1.15e-9 Developmental language disorder (linguistic errors); CRC cis rs4969178 0.965 rs16971105 chr17:76393975 G/T cg05887092 chr17:76393375 PGS1 0.52 9.46 0.46 6.3e-19 HDL cholesterol levels; CRC cis rs8180040 0.966 rs922957 chr3:47422152 G/C cg27129171 chr3:47204927 SETD2 -0.6 -9.37 -0.46 1.19e-18 Colorectal cancer; CRC cis rs9303280 0.806 rs12936409 chr17:38043649 C/T cg11212589 chr17:38028394 ZPBP2 0.43 7.93 0.4 3.39e-14 Self-reported allergy; CRC cis rs4253772 0.591 rs12167567 chr22:46659942 G/C cg24881330 chr22:46731750 TRMU 0.67 7.77 0.39 9.93e-14 LDL cholesterol;Cholesterol, total; CRC cis rs10751667 0.600 rs7950955 chr11:1011490 G/A cg23136738 chr11:925521 AP2A2 -0.38 -5.89 -0.31 9.65e-9 Alzheimer's disease (late onset); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg04485844 chr17:56296718 MKS1 0.44 6.39 0.33 5.83e-10 Intelligence (multi-trait analysis); CRC cis rs2245008 0.950 rs824400 chr16:83989936 C/G cg27171569 chr16:83987465 OSGIN1 -0.56 -9.13 -0.45 6.9e-18 Pursuit maintenance gain; CRC cis rs524281 0.773 rs2282568 chr11:66052832 C/G cg14036092 chr11:66035641 RAB1B -0.54 -5.97 -0.31 6.14e-9 Electroencephalogram traits; CRC cis rs4332037 0.906 rs62442903 chr7:1953416 G/A cg02421172 chr7:1938701 MAD1L1 0.49 6.61 0.34 1.59e-10 Bipolar disorder; CRC cis rs7772486 0.754 rs1415746 chr6:146077107 A/G cg05347473 chr6:146136440 FBXO30 -0.42 -6.33 -0.33 8e-10 Lobe attachment (rater-scored or self-reported); CRC cis rs28386778 0.897 rs6504177 chr17:61812655 C/T cg22520471 chr17:61851767 DDX42;CCDC47 0.69 10.69 0.51 4.23e-23 Prudent dietary pattern; CRC cis rs4713118 0.527 rs36042294 chr6:27720712 C/G cg03623178 chr6:28175578 NA 0.61 8.65 0.43 2.32e-16 Parkinson's disease; CRC cis rs7216064 1.000 rs8081517 chr17:65845697 A/T cg12091567 chr17:66097778 LOC651250 -0.63 -7.95 -0.4 3.08e-14 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CRC cis rs10504229 0.728 rs17804624 chr8:58154216 T/C cg02290350 chr8:58132656 NA -0.51 -6.57 -0.34 1.98e-10 Developmental language disorder (linguistic errors); CRC cis rs2880765 0.835 rs1872074 chr15:86033184 T/G cg17133734 chr15:86042851 AKAP13 0.43 6.73 0.35 7.69e-11 Coronary artery disease; CRC cis rs12586317 0.586 rs2295103 chr14:35515920 C/G cg16230307 chr14:35515116 FAM177A1 0.84 9.9 0.48 2.08e-20 Psoriasis; CRC cis rs12980942 0.872 rs7257583 chr19:41788117 T/C cg25627403 chr19:41769009 HNRNPUL1 0.44 5.62 0.3 4.08e-8 Coronary artery disease; CRC cis rs959260 0.623 rs7207618 chr17:73321687 T/C cg14668889 chr17:73230827 NUP85 -0.52 -7.57 -0.39 3.79e-13 Systemic lupus erythematosus; CRC cis rs7586879 0.558 rs6718510 chr2:25122323 A/C cg04586622 chr2:25135609 ADCY3 -0.56 -10.45 -0.5 3.03e-22 Body mass index; CRC cis rs2011503 0.941 rs55765017 chr19:19368264 G/A cg11584989 chr19:19387371 SF4 0.59 6.72 0.35 7.95e-11 Bipolar disorder; CRC cis rs8072100 0.738 rs9900123 chr17:45549055 T/C cg25173405 chr17:45401733 C17orf57 -0.41 -6.33 -0.33 7.9e-10 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs11971779 0.680 rs1986447 chr7:139082080 G/C cg07862535 chr7:139043722 LUC7L2 0.57 7.35 0.38 1.61e-12 Diisocyanate-induced asthma; CRC cis rs9914988 0.943 rs9303621 chr17:27161138 A/G cg16670446 chr17:27188758 MIR451;MIR144 0.54 8.4 0.42 1.39e-15 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs1011108 0.561 rs1053807 chr2:26800422 G/A cg18742855 chr2:26800399 C2orf70 0.63 11.11 0.52 1.41e-24 Periodontal microbiota; CRC trans rs7937682 1.000 rs9734135 chr11:111536190 G/A cg18187862 chr3:45730750 SACM1L 0.48 6.96 0.36 1.91e-11 Primary sclerosing cholangitis; CRC trans rs1005277 0.603 rs1998062 chr10:38457652 G/C cg11292332 chr7:45801988 SEPT13 -0.35 -6.17 -0.32 2e-9 Extrinsic epigenetic age acceleration; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg19591439 chr19:11708747 ZNF627 0.42 6.24 0.33 1.35e-9 Intelligence (multi-trait analysis); CRC cis rs10191773 0.589 rs72831634 chr2:112946796 A/G cg04979063 chr2:113191202 RGPD5;RGPD8 0.65 5.74 0.3 2.15e-8 Yeast infection; CRC cis rs870825 0.616 rs4437295 chr4:185643336 C/T cg04058563 chr4:185651563 MLF1IP 0.72 9.42 0.46 8.15e-19 Blood protein levels; CRC cis rs4862750 0.832 rs9995958 chr4:187901764 G/A cg07414643 chr4:187882934 NA 0.39 6.95 0.36 1.94e-11 Lobe attachment (rater-scored or self-reported); CRC cis rs8072100 0.790 rs11656856 chr17:45714671 C/T cg08085267 chr17:45401833 C17orf57 0.52 7.59 0.39 3.32e-13 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs2115630 1.000 rs10220733 chr15:85280864 G/A cg09876464 chr15:85330779 ZNF592 0.44 7.31 0.37 2e-12 P wave terminal force; CRC cis rs7845219 0.539 rs713113 chr8:95877787 C/T cg13393036 chr8:95962371 TP53INP1 0.42 6.86 0.35 3.4e-11 Type 2 diabetes; CRC cis rs7666738 0.830 rs36028444 chr4:98968635 G/T cg17366294 chr4:99064904 C4orf37 0.42 7.21 0.37 3.76e-12 Colonoscopy-negative controls vs population controls; CRC cis rs1448094 0.512 rs7313035 chr12:86250100 C/G cg00310523 chr12:86230176 RASSF9 0.35 5.93 0.31 7.63e-9 Major depressive disorder; CRC cis rs2462686 1.000 rs1525828 chr7:46002078 T/A cg23193639 chr7:45961078 IGFBP3 -0.38 -5.86 -0.31 1.14e-8 Major depressive disorder; CRC cis rs597539 0.652 rs546382 chr11:68704264 C/T cg04772025 chr11:68637568 NA 0.48 7.31 0.37 2.07e-12 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs1799949 0.965 rs8176161 chr17:41241390 C/A cg23758822 chr17:41437982 NA 0.81 13.76 0.6 2.44e-34 Menopause (age at onset); CRC cis rs9549328 0.700 rs2185001 chr13:113616369 G/T cg20742385 chr13:113633654 MCF2L -0.64 -10.78 -0.51 2.13e-23 Systolic blood pressure; CRC cis rs7707921 0.767 rs6894520 chr5:81594748 C/T cg21483461 chr5:81570383 RPS23 -0.37 -5.86 -0.31 1.1e-8 Breast cancer; CRC cis rs2070488 0.965 rs2300668 chr3:38540541 A/G cg01465620 chr3:38496096 LOC100128640;ACVR2B -0.83 -14.94 -0.64 6.9e-39 Electrocardiographic conduction measures; CRC cis rs7927771 0.690 rs35496532 chr11:47450338 C/T cg20307385 chr11:47447363 PSMC3 -0.62 -9.02 -0.45 1.64e-17 Subjective well-being; CRC cis rs12142240 0.698 rs68083747 chr1:46807416 T/G cg00530320 chr1:46809349 NSUN4 0.58 7.98 0.4 2.46e-14 Menopause (age at onset); CRC cis rs4731207 0.596 rs12538171 chr7:124645570 A/G cg23710748 chr7:124431027 NA -0.39 -6.25 -0.33 1.24e-9 Cutaneous malignant melanoma; CRC cis rs4689592 0.503 rs3857180 chr4:7073899 T/G cg26116260 chr4:7069785 GRPEL1 -0.88 -10.57 -0.5 1.13e-22 Monocyte percentage of white cells; CRC cis rs2841277 0.708 rs11851053 chr14:105407208 T/C cg14403583 chr14:105418241 AHNAK2 -0.34 -6.07 -0.32 3.47e-9 Rheumatoid arthritis; CRC cis rs929354 0.742 rs6459734 chr7:156935454 A/G cg17757837 chr7:157058334 UBE3C 0.74 12.39 0.56 3.31e-29 Body mass index; CRC cis rs7666738 0.830 rs11725095 chr4:99009711 T/A cg17366294 chr4:99064904 C4orf37 0.44 7.39 0.38 1.19e-12 Colonoscopy-negative controls vs population controls; CRC cis rs13191362 0.935 rs35942036 chr6:163163297 C/T cg06582575 chr6:163149167 PACRG;PARK2 0.92 11.67 0.54 1.42e-26 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs4862750 0.872 rs6825289 chr4:187879109 T/G cg03647317 chr4:187891568 NA -0.54 -10.06 -0.49 6.03e-21 Lobe attachment (rater-scored or self-reported); CRC cis rs853679 0.517 rs36078605 chr6:28078032 A/C cg25164649 chr6:28176230 NA 0.77 9.53 0.46 3.69e-19 Depression; CRC cis rs3087591 0.708 rs9894648 chr17:29653293 T/C cg24425628 chr17:29625626 OMG;NF1 0.64 10.64 0.51 6.33e-23 Hip circumference; CRC trans rs79976124 0.837 rs12194087 chr6:66644399 T/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.73 9.22 0.45 3.56e-18 Type 2 diabetes; CRC cis rs6582630 0.555 rs2197308 chr12:38281261 A/G cg26384229 chr12:38710491 ALG10B -0.52 -7.55 -0.38 4.19e-13 Drug-induced liver injury (flucloxacillin); CRC cis rs2976388 0.647 rs2244163 chr8:143784500 T/G cg22687807 chr8:143858763 LYNX1 0.49 8.69 0.43 1.68e-16 Urinary tract infection frequency; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg17609050 chr7:92861606 CCDC132 0.48 6.18 0.32 1.89e-9 Thyroid stimulating hormone; CRC cis rs6500395 1.000 rs9933187 chr16:48556573 A/C cg04672837 chr16:48644449 N4BP1 -0.42 -6.08 -0.32 3.41e-9 Response to tocilizumab in rheumatoid arthritis; CRC cis rs6424115 0.679 rs2294495 chr1:24075876 C/T cg10978503 chr1:24200527 CNR2 -0.44 -6.55 -0.34 2.24e-10 Immature fraction of reticulocytes; CRC cis rs9660180 0.967 rs6603803 chr1:1812688 A/G cg03396347 chr1:1875803 NA -0.61 -9.5 -0.46 4.42e-19 Body mass index; CRC cis rs9291683 0.609 rs4622999 chr4:10003395 C/G cg11266682 chr4:10021025 SLC2A9 0.55 11.79 0.54 5.49e-27 Bone mineral density; CRC cis rs9435341 0.896 rs1623927 chr1:107596120 T/C cg15468180 chr1:107600409 PRMT6 -0.44 -6.42 -0.33 4.72e-10 Facial morphology (factor 21, depth of nasal alae); CRC cis rs4481887 0.676 rs28684663 chr1:248548325 T/C cg00666640 chr1:248458726 OR2T12 0.37 6.84 0.35 3.88e-11 Common traits (Other); CRC cis rs4363385 0.747 rs946098 chr1:152975038 A/C cg25856811 chr1:152973957 SPRR3 -0.26 -7.24 -0.37 3.22e-12 Inflammatory skin disease; CRC cis rs2075371 0.933 rs2544201 chr7:133963561 C/G cg11752832 chr7:134001865 SLC35B4 0.42 6.37 0.33 6.5e-10 Mean platelet volume; CRC cis rs2408955 0.501 rs8716 chr12:48539482 T/G cg00601486 chr12:48723148 H1FNT 0.34 6.54 0.34 2.33e-10 Glycated hemoglobin levels; CRC cis rs7072216 0.770 rs1061115 chr10:100177049 G/A cg26618903 chr10:100175079 PYROXD2 -0.43 -7.18 -0.37 4.72e-12 Metabolite levels; CRC cis rs4604732 0.631 rs74154675 chr1:247625836 G/A cg12758973 chr1:247694275 LOC148824;OR2C3 0.42 6.14 0.32 2.32e-9 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CRC cis rs672059 0.513 rs627064 chr1:183165716 C/T cg05929019 chr1:183155154 LAMC2 -0.38 -6.95 -0.36 1.93e-11 Hypertriglyceridemia; CRC cis rs669446 0.533 rs3791042 chr1:44219275 T/C cg12908607 chr1:44402522 ARTN -0.34 -5.94 -0.31 7.2e-9 Amyotrophic lateral sclerosis (age of onset); CRC cis rs9435341 0.965 rs1730862 chr1:107614003 G/A cg14671364 chr1:107599128 PRMT6 -0.57 -7.78 -0.39 9.76e-14 Facial morphology (factor 21, depth of nasal alae); CRC trans rs6671200 0.920 rs11165339 chr1:95674064 T/C cg04454259 chr21:37507390 CBR3 -0.63 -6.02 -0.31 4.74e-9 Stearic acid (18:0) levels; CRC cis rs5758511 0.634 rs1001587 chr22:42670111 C/T cg00645731 chr22:42541494 CYP2D7P1 0.63 9.65 0.47 1.44e-19 Birth weight; CRC cis rs897984 0.762 rs12930545 chr16:30938811 A/G cg00531865 chr16:30841666 NA 0.5 7.03 0.36 1.2e-11 Dementia with Lewy bodies; CRC cis rs10791097 0.694 rs7107595 chr11:130758556 C/T cg12179176 chr11:130786555 SNX19 0.76 12.25 0.56 1.11e-28 Autism spectrum disorder or schizophrenia;Schizophrenia; CRC cis rs12928939 0.769 rs12445161 chr16:71741928 C/T cg08717414 chr16:71523259 ZNF19 -0.46 -5.83 -0.31 1.3e-8 Post bronchodilator FEV1; CRC cis rs4713118 0.699 rs200978 chr6:27853168 C/G cg23161317 chr6:28129485 ZNF389 0.47 6.08 0.32 3.3e-9 Parkinson's disease; CRC cis rs7072216 0.881 rs11189591 chr10:100155296 T/G cg26618903 chr10:100175079 PYROXD2 -0.36 -6.16 -0.32 2.14e-9 Metabolite levels; CRC cis rs12142240 0.621 rs66828173 chr1:46818166 G/A cg00530320 chr1:46809349 NSUN4 0.58 8.01 0.4 1.95e-14 Menopause (age at onset); CRC cis rs1475911 0.507 rs11702347 chr21:43526454 C/T cg24372256 chr21:43528868 UMODL1;C21orf128 -0.7 -9.19 -0.45 4.47e-18 IgG glycosylation; CRC cis rs3087591 0.960 rs2905883 chr17:29550141 G/A cg24425628 chr17:29625626 OMG;NF1 0.88 17.16 0.69 1.37e-47 Hip circumference; CRC cis rs8044868 0.530 rs2550870 chr16:72070129 C/T cg23815491 chr16:72088622 HP 0.48 7.0 0.36 1.42e-11 Body mass index (change over time) in cancer or chronic obstructive pulmonary disease;Body mass index (change over time) in cancer; CRC cis rs34779708 0.966 rs4934540 chr10:35474699 T/C cg03585969 chr10:35415529 CREM 0.55 7.45 0.38 8.25e-13 Inflammatory bowel disease;Crohn's disease; CRC cis rs7772486 0.875 rs2814877 chr6:146299763 C/G cg13319975 chr6:146136371 FBXO30 -0.38 -5.7 -0.3 2.7e-8 Lobe attachment (rater-scored or self-reported); CRC cis rs11098499 0.954 rs7437420 chr4:120312903 A/G cg24375607 chr4:120327624 NA 0.51 7.8 0.39 8.42e-14 Corneal astigmatism; CRC cis rs10504229 1.000 rs17216620 chr8:58169412 A/G cg21724239 chr8:58056113 NA 0.39 5.6 0.3 4.43e-8 Developmental language disorder (linguistic errors); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg04593550 chr5:56206289 C5orf35 0.37 6.05 0.32 3.89e-9 Liver disease severity in Alagille syndrome; CRC cis rs7666738 0.753 rs11097607 chr4:99011640 C/T cg17366294 chr4:99064904 C4orf37 0.44 7.35 0.38 1.55e-12 Colonoscopy-negative controls vs population controls; CRC cis rs4076764 1.000 rs4076764 chr1:163441286 A/G cg06092702 chr1:163392909 NA -0.57 -9.14 -0.45 6.81e-18 Motion sickness; CRC trans rs1973993 0.691 rs1980684 chr1:96890636 A/G cg10631902 chr5:14652156 NA 0.62 12.44 0.57 2.14e-29 Weight; CRC cis rs611744 0.647 rs1448151 chr8:109276283 C/A cg18478394 chr8:109455254 TTC35 0.38 5.82 0.31 1.38e-8 Dupuytren's disease; CRC trans rs875971 0.660 rs2191268 chr7:66110224 C/T cg19858671 chr8:130951373 FAM49B -0.39 -6.18 -0.32 1.93e-9 Aortic root size; CRC cis rs9487023 1 rs9487023 chr6:109590004 A/G cg21918786 chr6:109611834 NA -0.38 -6.55 -0.34 2.16e-10 Red blood cell count;Mean corpuscular hemoglobin concentration;Neutrophil percentage of white cells;Lymphocyte percentage of white cells;Mean corpuscular hemoglobin;High light scatter reticulocyte percentage of red cells;Mean corpuscular volume; CRC cis rs7647973 1.000 rs9871024 chr3:49554241 T/C cg07636037 chr3:49044803 WDR6 -0.67 -8.02 -0.4 1.87e-14 Menarche (age at onset); CRC cis rs1552244 0.935 rs35586456 chr3:10116938 A/G cg13047869 chr3:10149882 C3orf24 0.53 7.44 0.38 8.73e-13 Alzheimer's disease; CRC cis rs9326248 0.861 rs4938348 chr11:117021877 G/C cg26566898 chr11:117069891 TAGLN 0.39 7.02 0.36 1.24e-11 Blood protein levels; CRC cis rs3749237 0.595 rs12489092 chr3:49550914 G/C cg07636037 chr3:49044803 WDR6 0.55 8.06 0.41 1.42e-14 Resting heart rate; CRC cis rs10484885 0.648 rs2777848 chr6:90535993 G/A cg13799429 chr6:90582589 CASP8AP2 -0.83 -12.65 -0.57 3.64e-30 QRS interval (sulfonylurea treatment interaction); CRC cis rs870825 0.616 rs6818447 chr4:185650154 G/A cg04058563 chr4:185651563 MLF1IP 0.72 9.28 0.46 2.4e-18 Blood protein levels; CRC cis rs10504229 0.683 rs67077711 chr8:58139769 G/T cg05313129 chr8:58192883 C8orf71 -0.43 -6.11 -0.32 2.74e-9 Developmental language disorder (linguistic errors); CRC cis rs11587400 0.679 rs12090305 chr1:115109441 G/A cg12756093 chr1:115239321 AMPD1 0.43 5.9 0.31 9.27e-9 Autism; CRC trans rs9291683 0.609 rs12507050 chr4:10007305 G/T cg26043149 chr18:55253948 FECH 0.53 8.1 0.41 1.11e-14 Bone mineral density; CRC trans rs79976124 0.876 rs17511913 chr6:66644361 C/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.73 9.22 0.45 3.56e-18 Type 2 diabetes; CRC cis rs13096357 0.520 rs17080319 chr3:48732480 T/C cg07636037 chr3:49044803 WDR6 -0.66 -6.55 -0.34 2.17e-10 Cognitive ability (multi-trait analysis); CRC cis rs360798 0.512 rs9973612 chr2:63019815 G/C cg17519650 chr2:63277830 OTX1 -0.44 -6.16 -0.32 2.07e-9 Coronary artery disease; CRC cis rs780094 0.544 rs2303370 chr2:27651375 C/T cg17158414 chr2:27665306 KRTCAP3 -0.26 -5.63 -0.3 3.79e-8 Calcium levels;Fasting blood insulin;Metabolic traits;Triglyceride levels;Fasting plasma glucose;Urate levels in overweight individuals;Urate levels in obese individuals;Uric acid levels;Height;Age-related diseases, mortality and associated endophenotypes;Renal underexcretion gout;Fasting blood glucose (BMI interaction);Urate levels;Gondoic acid (20:1n-9) levels;Fasting blood insulin (BMI interaction);Triglycerides;Plasma omega-3 polyunsaturated fatty acid levels (docosapentaenoic acid);Type 2 diabetes;Nonalcoholic fatty liver disease;Hypertriglyceridemia;C-reactive protein;Age-related disease endophenotypes;LDL cholesterol;Metabolic syndrome;Crohn's disease;Alcohol consumption (drinks per week);Homeostasis model assessment of insulin resistance;Alcohol consumption;Red blood cell count;Fasting blood glucose; CRC cis rs425277 1.000 rs262647 chr1:2095699 C/T cg24578937 chr1:2090814 PRKCZ 0.66 11.77 0.54 6.24e-27 Height; CRC cis rs17826219 0.706 rs28469200 chr17:29133572 T/A cg13385521 chr17:29058706 SUZ12P 0.71 8.22 0.41 4.82e-15 Body mass index; CRC cis rs651907 0.557 rs7651406 chr3:101393296 C/T cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.68 9.53 0.47 3.56e-19 Colorectal cancer; CRC cis rs7772486 0.686 rs4896828 chr6:145953339 A/C cg23711669 chr6:146136114 FBXO30 0.67 11.13 0.52 1.28e-24 Lobe attachment (rater-scored or self-reported); CRC cis rs7312933 0.509 rs1920685 chr12:42428674 A/G cg11827402 chr12:42719852 PPHLN1;ZCRB1 0.58 6.18 0.32 1.88e-9 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CRC cis rs3823572 0.542 rs2346269 chr7:133643066 C/T cg03336402 chr7:133662267 EXOC4 -0.68 -10.48 -0.5 2.32e-22 Intelligence (multi-trait analysis); CRC cis rs6952808 0.609 rs11772205 chr7:1951236 C/T cg22963979 chr7:1858916 MAD1L1 -0.43 -6.76 -0.35 6.36e-11 Bipolar disorder and schizophrenia; CRC cis rs7208859 0.673 rs73265633 chr17:29236306 G/T cg13385521 chr17:29058706 SUZ12P 0.69 7.99 0.4 2.27e-14 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs853679 0.517 rs9393890 chr6:28063855 C/T cg15786705 chr6:28176104 NA 0.76 9.6 0.47 2.1e-19 Depression; CRC cis rs875971 0.862 rs880166 chr7:65670762 T/C cg18876405 chr7:65276391 NA -0.53 -8.74 -0.43 1.21e-16 Aortic root size; CRC cis rs9462027 0.628 rs2764211 chr6:34704613 C/T cg07306190 chr6:34760872 UHRF1BP1 0.35 6.3 0.33 9.8e-10 Systemic lupus erythematosus; CRC cis rs7089973 0.872 rs7072364 chr10:116620840 G/A cg03647239 chr10:116582469 FAM160B1 0.41 5.71 0.3 2.59e-8 Bipolar disorder or attention deficit hyperactivity disorder; CRC cis rs597539 0.552 rs6591360 chr11:68718669 G/T cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.77 12.54 0.57 9.25e-30 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs4665809 0.590 rs10179959 chr2:26426403 G/A cg26119090 chr2:26468346 HADHA;HADHB -1.06 -15.2 -0.64 6.61e-40 Gut microbiome composition (summer); CRC cis rs769267 0.930 rs6909 chr19:19619542 A/G cg02546618 chr19:19431379 KIAA0892;SF4 0.44 6.08 0.32 3.33e-9 Tonsillectomy; CRC trans rs7937682 0.921 rs7130753 chr11:111470567 C/T cg18187862 chr3:45730750 SACM1L -0.58 -7.46 -0.38 7.69e-13 Primary sclerosing cholangitis; CRC cis rs10504229 1.000 rs55787104 chr8:58178519 C/T cg02290350 chr8:58132656 NA -0.41 -5.88 -0.31 1.03e-8 Developmental language disorder (linguistic errors); CRC cis rs10752881 1.000 rs12028740 chr1:182985581 G/A ch.1.3577855R chr1:183094577 LAMC1 0.86 15.22 0.64 5.91e-40 Colorectal cancer; CRC cis rs10504229 0.545 rs56394419 chr8:58128982 T/C cg24829409 chr8:58192753 C8orf71 -0.55 -8.03 -0.4 1.71e-14 Developmental language disorder (linguistic errors); CRC cis rs7312933 0.558 rs1796388 chr12:42785987 G/C cg11827402 chr12:42719852 PPHLN1;ZCRB1 -0.67 -9.96 -0.48 1.35e-20 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CRC cis rs3812049 0.532 rs251216 chr5:127543280 A/G cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.64 7.87 0.4 5.07e-14 Lymphocyte counts;Red cell distribution width; CRC trans rs61931739 0.500 rs7306053 chr12:34510848 T/G cg13010199 chr12:38710504 ALG10B 0.45 6.51 0.34 2.88e-10 Morning vs. evening chronotype; CRC cis rs16867321 0.588 rs1919156 chr2:181456978 C/T cg23363182 chr2:181467187 NA -0.62 -9.38 -0.46 1.12e-18 Obesity; CRC cis rs4819052 0.724 rs9753962 chr21:46661384 G/T cg11663144 chr21:46675770 NA -0.83 -14.12 -0.61 9.88e-36 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs6964587 0.867 rs12704637 chr7:91874686 C/T cg17063962 chr7:91808500 NA 0.75 11.11 0.52 1.42e-24 Breast cancer; CRC cis rs875971 0.545 rs313828 chr7:65552614 T/C cg02869306 chr7:64672164 INTS4L1 0.44 6.17 0.32 1.98e-9 Aortic root size; CRC cis rs2836950 0.520 rs2836966 chr21:40637521 A/G cg06238570 chr21:40685208 BRWD1 -0.6 -8.71 -0.43 1.53e-16 Menarche (age at onset); CRC cis rs4700695 0.719 rs27085 chr5:65435063 C/T cg21114390 chr5:65439923 SFRS12 0.63 8.48 0.42 7.67e-16 Facial morphology (factor 19); CRC cis rs62458065 1.000 rs10231294 chr7:32465357 C/T cg20159608 chr7:32802032 NA -0.5 -6.31 -0.33 8.83e-10 Metabolite levels (HVA/MHPG ratio); CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg09655822 chr6:146136083 FBXO30 -0.4 -6.01 -0.31 5.05e-9 Myopia (pathological); CRC trans rs8073060 0.586 rs225303 chr17:33922149 A/G cg19694781 chr19:47549865 TMEM160 1.02 14.75 0.63 3.74e-38 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; CRC cis rs2228479 0.850 rs2190808 chr16:89840856 C/T cg06656553 chr16:89960601 TCF25 -0.71 -5.96 -0.31 6.42e-9 Skin colour saturation; CRC cis rs7586879 0.593 rs11689543 chr2:25130440 A/T cg04586622 chr2:25135609 ADCY3 -0.55 -10.26 -0.49 1.26e-21 Body mass index; CRC cis rs2404602 0.536 rs17364330 chr15:76765385 A/T cg22467129 chr15:76604101 ETFA -0.42 -7.25 -0.37 3.04e-12 Blood metabolite levels; CRC cis rs55823223 0.702 rs3785437 chr17:73906222 G/T cg08125733 chr17:73851984 WBP2 0.99 7.68 0.39 1.79e-13 Psoriasis; CRC cis rs172166 0.637 rs1225597 chr6:28162087 C/T cg21251018 chr6:28226885 NKAPL 0.49 7.72 0.39 1.44e-13 Cardiac Troponin-T levels; CRC cis rs6988985 0.728 rs5017238 chr8:143954769 G/A cg10324643 chr8:143916377 GML 0.35 5.8 0.3 1.53e-8 Plasma androstenedione levels in resected early stage-receptor positive breast cancer; CRC cis rs1218582 0.772 rs1109815 chr1:154909268 A/G cg06221963 chr1:154839813 KCNN3 -0.75 -14.69 -0.63 6.48e-38 Prostate cancer; CRC cis rs910316 1.000 rs4899546 chr14:75594946 G/C cg11812906 chr14:75593930 NEK9 0.63 10.1 0.49 4.59e-21 Height; CRC cis rs28386778 0.863 rs7221573 chr17:61859390 G/A cg06601766 chr17:61851465 DDX42;CCDC47 0.44 6.04 0.32 4.16e-9 Prudent dietary pattern; CRC cis rs11583043 0.918 rs56402739 chr1:101397133 A/G cg00063077 chr1:101360652 SLC30A7;EXTL2 0.5 6.75 0.35 6.87e-11 Ulcerative colitis;Inflammatory bowel disease; CRC cis rs4234798 0.588 rs4689640 chr4:7214066 G/A cg18431297 chr4:7219810 SORCS2 0.51 7.99 0.4 2.27e-14 Insulin-like growth factors; CRC cis rs875971 0.545 rs73142265 chr7:65699497 G/A cg03233332 chr7:66118400 NA -0.43 -5.84 -0.31 1.28e-8 Aortic root size; CRC cis rs7264396 0.563 rs17093093 chr20:34380925 T/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.44 -6.33 -0.33 8.12e-10 Total cholesterol levels; CRC cis rs7927771 0.832 rs10838698 chr11:47385923 G/A cg05585544 chr11:47624801 NA 0.49 8.92 0.44 3.21e-17 Subjective well-being; CRC cis rs79839061 0.610 rs2279181 chr4:882643 A/G cg14530993 chr4:882597 GAK -0.74 -7.58 -0.39 3.56e-13 Intelligence (multi-trait analysis); CRC cis rs7772486 0.558 rs2142978 chr6:146012061 T/C cg13319975 chr6:146136371 FBXO30 0.63 9.16 0.45 5.64e-18 Lobe attachment (rater-scored or self-reported); CRC cis rs13256369 0.851 rs13267036 chr8:8566685 G/A cg00074818 chr8:8560427 CLDN23 0.42 7.44 0.38 8.72e-13 Obesity-related traits; CRC cis rs7894051 0.764 rs11101725 chr10:135194608 A/G cg20534287 chr10:135191450 PAOX -0.82 -7.17 -0.37 5.12e-12 Lifespan; CRC cis rs28386778 0.897 rs7222189 chr17:61836372 T/C cg06873352 chr17:61820015 STRADA 0.75 14.2 0.62 5.17e-36 Prudent dietary pattern; CRC trans rs7615952 0.543 rs4645102 chr3:125424441 A/G cg16558177 chr4:4109446 NA -0.62 -8.92 -0.44 3.38e-17 Blood pressure (smoking interaction); CRC cis rs6426558 0.537 rs7512409 chr1:227484038 A/G cg10327440 chr1:227177885 CDC42BPA -0.44 -6.58 -0.34 1.86e-10 Neutrophil percentage of white cells; CRC cis rs1707322 1.000 rs9803784 chr1:46401907 T/C cg06784218 chr1:46089804 CCDC17 0.51 9.07 0.45 1.11e-17 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs3789045 0.560 rs4553256 chr1:204411144 C/T cg17419461 chr1:204415978 PIK3C2B -0.81 -10.84 -0.51 1.31e-23 Educational attainment (college completion); CRC cis rs6952808 0.609 rs11772205 chr7:1951236 C/T cg21782813 chr7:2030301 MAD1L1 0.4 7.29 0.37 2.37e-12 Bipolar disorder and schizophrenia; CRC trans rs7267979 0.903 rs1118963 chr20:25247449 G/A cg17903999 chr18:56338584 MALT1 -0.41 -6.49 -0.34 3.23e-10 Liver enzyme levels (alkaline phosphatase); CRC cis rs7428 0.527 rs1053560 chr2:85546192 C/T cg24342717 chr2:85555507 TGOLN2 -0.78 -13.17 -0.59 4.04e-32 Ear protrusion; CRC cis rs4319547 0.656 rs10846664 chr12:122823777 C/T cg05707623 chr12:122985044 ZCCHC8 0.69 8.52 0.43 5.85e-16 Body mass index; CRC trans rs7829975 0.688 rs13270194 chr8:8378102 T/C cg16141378 chr3:129829833 LOC729375 -0.52 -7.83 -0.4 6.63e-14 Mood instability; CRC cis rs651907 0.535 rs11714444 chr3:101513682 G/A cg12386194 chr3:101231763 SENP7 0.52 7.45 0.38 8.46e-13 Colorectal cancer; CRC trans rs6413860 0.688 rs10802434 chr1:246859182 G/T cg25623271 chr1:240656217 GREM2 0.44 6.21 0.32 1.59e-9 Gut microbiome composition (summer); CRC cis rs801193 0.660 rs1016265 chr7:66214567 C/T cg12463550 chr7:65579703 CRCP 0.45 6.25 0.33 1.26e-9 Aortic root size; CRC cis rs6456156 0.565 rs6921588 chr6:167494397 G/T cg07741184 chr6:167504864 NA 0.47 7.83 0.4 6.69e-14 Primary biliary cholangitis; CRC cis rs10504229 0.769 rs17215649 chr8:58152791 A/G cg05313129 chr8:58192883 C8orf71 -0.47 -6.18 -0.32 1.94e-9 Developmental language disorder (linguistic errors); CRC cis rs6500395 1.000 rs871903 chr16:48593643 A/C cg04672837 chr16:48644449 N4BP1 0.45 6.66 0.34 1.18e-10 Response to tocilizumab in rheumatoid arthritis; CRC cis rs13256369 1.000 rs4841017 chr8:8577093 A/G cg17143192 chr8:8559678 CLDN23 0.46 6.33 0.33 8.15e-10 Obesity-related traits; CRC cis rs4240897 0.935 rs2236055 chr1:12042261 A/G cg13216073 chr1:12042593 MFN2 0.65 10.92 0.52 6.97e-24 Tuberculosis; CRC cis rs8014204 0.804 rs34956813 chr14:75254167 G/A cg03030879 chr14:75389066 RPS6KL1 -0.49 -7.83 -0.4 6.72e-14 Caffeine consumption; CRC cis rs7615952 0.512 rs4646765 chr3:125820707 G/A cg04553112 chr3:125709451 NA -0.53 -6.06 -0.32 3.68e-9 Blood pressure (smoking interaction); CRC cis rs7811142 0.830 rs11761253 chr7:99939321 C/T cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.13 15.83 0.66 2.26e-42 Platelet count; CRC cis rs2721195 0.654 rs4610795 chr8:145881333 C/T cg15857475 chr8:145742913 RECQL4;LRRC14 -0.68 -11.34 -0.53 2.15e-25 Age at first birth; CRC cis rs9479482 1.000 rs9479482 chr6:150358012 T/C cg25797454 chr6:150327115 RAET1K 0.38 6.47 0.34 3.48e-10 Alopecia areata; CRC cis rs6066835 0.867 rs6095271 chr20:47356176 C/G cg18078177 chr20:47281410 PREX1 0.63 5.93 0.31 7.49e-9 Multiple myeloma; CRC trans rs7395662 0.591 rs4882012 chr11:48560597 T/A cg00717180 chr2:96193071 NA -0.36 -6.0 -0.31 5.3e-9 HDL cholesterol; CRC cis rs4722166 0.508 rs1474347 chr7:22768124 A/C cg05472934 chr7:22766657 IL6 -0.69 -11.41 -0.53 1.24e-25 Lung cancer; CRC cis rs4285028 0.847 rs1986712 chr3:121710986 A/G cg11130432 chr3:121712080 ILDR1 -0.52 -6.5 -0.34 3.03e-10 Multiple sclerosis; CRC trans rs2243480 1.000 rs73142122 chr7:65311298 C/A cg10756647 chr7:56101905 PSPH 0.69 7.1 0.36 7.8e-12 Diabetic kidney disease; CRC cis rs3091242 0.933 rs61775167 chr1:25780893 A/G cg27572855 chr1:25598939 RHD -0.35 -6.08 -0.32 3.31e-9 Erythrocyte sedimentation rate; CRC cis rs2298450 0.550 rs7280997 chr21:37658509 C/T cg02919814 chr21:37666008 DOPEY2 -0.4 -5.94 -0.31 7.28e-9 Schizophrenia; CRC cis rs7072216 0.763 rs45523432 chr10:100167436 T/C cg26618903 chr10:100175079 PYROXD2 -0.55 -9.26 -0.45 2.73e-18 Metabolite levels; CRC trans rs7618501 0.633 rs11925192 chr3:50038664 G/A cg21659725 chr3:3221576 CRBN 0.52 7.96 0.4 2.72e-14 Intelligence (multi-trait analysis); CRC cis rs17376456 0.569 rs2045021 chr5:93224222 G/A cg09848695 chr5:92956644 FAM172A;MIR2277 -0.53 -6.16 -0.32 2.16e-9 Diabetic retinopathy; CRC cis rs7072216 0.655 rs3830024 chr10:100176106 G/A cg26618903 chr10:100175079 PYROXD2 -0.52 -8.24 -0.41 4.22e-15 Metabolite levels; CRC cis rs12762955 0.507 rs10737004 chr10:1039019 T/C cg19847866 chr10:1019161 NA 0.39 5.74 0.3 2.11e-8 Response to angiotensin II receptor blocker therapy; CRC cis rs17401966 0.838 rs4475756 chr1:10387788 A/G cg19773385 chr1:10388646 KIF1B -0.64 -10.21 -0.49 1.88e-21 Hepatocellular carcinoma; CRC cis rs9303401 0.573 rs62081879 chr17:57181524 C/T cg02118635 chr17:56770003 RAD51C;TEX14 0.76 9.09 0.45 9.67e-18 Cognitive test performance; CRC cis rs11191205 0.686 rs11191067 chr10:103379882 G/T cg15320455 chr10:103880129 LDB1 0.54 5.98 0.31 5.78e-9 Intelligence (multi-trait analysis); CRC cis rs9322193 0.923 rs9479494 chr6:150060244 A/G cg13206674 chr6:150067644 NUP43 0.68 10.39 0.5 4.69e-22 Lung cancer; CRC cis rs2066819 1.000 rs77447765 chr12:56690662 G/A cg26714650 chr12:56694279 CS -1.41 -11.64 -0.54 1.88e-26 Psoriasis vulgaris; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg02315113 chr1:173684045 KLHL20 0.54 7.16 0.37 5.34e-12 Thyroid stimulating hormone; CRC cis rs3099143 1.000 rs1913001 chr15:77179408 A/C cg21673338 chr15:77095150 SCAPER 0.74 7.43 0.38 9.15e-13 Recalcitrant atopic dermatitis; CRC cis rs7833986 0.501 rs2953898 chr8:56980803 C/T cg23139584 chr8:56987506 RPS20;SNORD54 0.91 12.57 0.57 7.49e-30 Height; CRC cis rs9303401 0.592 rs12936771 chr17:56725052 T/C cg02118635 chr17:56770003 RAD51C;TEX14 0.79 9.9 0.48 2.16e-20 Cognitive test performance; CRC cis rs7586879 0.662 rs2384059 chr2:25100338 C/T cg22495460 chr2:25135724 ADCY3 -0.85 -16.22 -0.67 7.02e-44 Body mass index; CRC cis rs9322193 0.926 rs3805751 chr6:150112329 G/A cg07701084 chr6:150067640 NUP43 0.48 6.77 0.35 6.07e-11 Lung cancer; CRC cis rs561341 0.941 rs7215147 chr17:30266711 G/A cg12193833 chr17:30244370 NA -0.57 -8.01 -0.4 2.07e-14 Hip circumference adjusted for BMI; CRC trans rs561341 0.882 rs563539 chr17:30307958 A/G cg27661571 chr11:113659931 NA -0.71 -8.91 -0.44 3.49e-17 Hip circumference adjusted for BMI; CRC cis rs7647973 0.710 rs1491983 chr3:49639803 G/T cg13072238 chr3:49761600 GMPPB -0.51 -5.81 -0.3 1.5e-8 Menarche (age at onset); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg10336722 chr1:54665764 CYB5RL;MRPL37 0.49 7.04 0.36 1.14e-11 Response to antipsychotic treatment; CRC cis rs2295359 1.000 rs4655682 chr1:67610967 C/T cg03340356 chr1:67600835 NA 0.25 5.78 0.3 1.72e-8 Psoriasis; CRC cis rs2032447 0.839 rs199750 chr6:26016462 A/G cg27635394 chr6:26043820 HIST1H2BB -0.44 -6.43 -0.33 4.44e-10 Intelligence (multi-trait analysis); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg03193349 chr6:139309610 REPS1 0.51 7.28 0.37 2.41e-12 Response to antipsychotic treatment; CRC cis rs10504229 0.683 rs34804288 chr8:58117570 C/A cg21724239 chr8:58056113 NA 0.49 6.81 0.35 4.75e-11 Developmental language disorder (linguistic errors); CRC cis rs13118159 0.836 rs12647145 chr4:1338618 C/A cg15763984 chr4:1342303 KIAA1530 0.35 6.0 0.31 5.28e-9 Longevity; CRC cis rs9325144 0.560 rs11183090 chr12:38662293 G/C cg26384229 chr12:38710491 ALG10B -0.49 -7.26 -0.37 2.89e-12 Morning vs. evening chronotype; CRC cis rs13108904 0.967 rs11727167 chr4:1285521 A/G cg02018176 chr4:1364513 KIAA1530 0.47 7.66 0.39 2.07e-13 Obesity-related traits; CRC cis rs10782582 0.609 rs1251584 chr1:76424440 C/T cg10523679 chr1:76189770 ACADM 0.41 5.79 0.3 1.64e-8 Daytime sleep phenotypes; CRC cis rs9443645 0.901 rs9352675 chr6:79612800 G/A cg09184832 chr6:79620586 NA -0.52 -9.73 -0.47 7.62e-20 Intelligence (multi-trait analysis); CRC cis rs4970988 0.787 rs1532770 chr1:150725335 G/T cg15448220 chr1:150897856 SETDB1 0.5 6.97 0.36 1.74e-11 Urate levels; CRC cis rs6684514 1.000 rs6684514 chr1:156255456 G/A cg16558208 chr1:156270281 VHLL 0.59 9.15 0.45 6.25e-18 Mean corpuscular hemoglobin concentration;Glycated hemoglobin levels; CRC trans rs264943 0.600 rs11677228 chr2:104096243 G/A cg24033067 chr14:24674799 TSSK4 -0.41 -6.01 -0.31 4.8e-9 HIV-1 viral setpoint; CRC cis rs72615157 0.634 rs2272343 chr7:99778285 A/C cg07160278 chr7:100027354 MEPCE;ZCWPW1 0.72 8.63 0.43 2.75e-16 Lung function (FEV1/FVC); CRC trans rs7746199 0.736 rs6904596 chr6:27491299 G/A cg06606381 chr12:133084897 FBRSL1 -0.82 -6.57 -0.34 1.92e-10 Gait speed in old age;Autism spectrum disorder or schizophrenia; CRC cis rs801193 1.000 rs2003301 chr7:66147656 G/C cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.43 -6.29 -0.33 9.91e-10 Aortic root size; CRC cis rs17826219 0.706 rs28469200 chr17:29133572 T/A cg01831904 chr17:28903510 LRRC37B2 -0.63 -6.6 -0.34 1.65e-10 Body mass index; CRC cis rs208520 0.954 rs12190073 chr6:66983740 T/C cg07460842 chr6:66804631 NA 0.91 11.17 0.52 8.75e-25 Exhaled nitric oxide output; CRC cis rs3749237 0.595 rs3870337 chr3:49557095 G/T cg07636037 chr3:49044803 WDR6 0.55 8.06 0.41 1.42e-14 Resting heart rate; CRC cis rs6500395 1.000 rs55671623 chr16:48631154 A/G cg04672837 chr16:48644449 N4BP1 0.44 6.6 0.34 1.69e-10 Response to tocilizumab in rheumatoid arthritis; CRC cis rs1336149 0.901 rs822430 chr1:156902259 A/G cg06374307 chr1:156893873 C1orf92 -0.25 -5.64 -0.3 3.72e-8 Chin dimples; CRC cis rs7607369 0.680 rs533760 chr2:219381405 T/C cg02176678 chr2:219576539 TTLL4 0.54 8.69 0.43 1.78e-16 Red blood cell count;Amyotrophic lateral sclerosis; CRC cis rs3823572 0.542 rs62470443 chr7:133627499 G/A cg03336402 chr7:133662267 EXOC4 0.67 10.11 0.49 4.31e-21 Intelligence (multi-trait analysis); CRC trans rs3780486 0.846 rs10813954 chr9:33137596 A/C cg04842962 chr6:43655489 MRPS18A 1.15 23.41 0.79 5.01e-72 IgG glycosylation; CRC cis rs898097 0.625 rs898095 chr17:80890638 T/C cg15369054 chr17:80825471 TBCD -0.35 -5.9 -0.31 8.9e-9 Breast cancer; CRC cis rs10078 0.571 rs2241597 chr5:480509 A/G cg26072250 chr5:443457 EXOC3;C5orf55 0.54 5.62 0.3 4.1e-8 Fat distribution (HIV); CRC cis rs9322193 0.923 rs9800686 chr6:149955600 A/C cg07701084 chr6:150067640 NUP43 0.56 7.86 0.4 5.57e-14 Lung cancer; CRC cis rs7772486 0.748 rs2748484 chr6:146333653 C/T cg23711669 chr6:146136114 FBXO30 0.61 10.35 0.5 6.37e-22 Lobe attachment (rater-scored or self-reported); CRC cis rs875971 0.928 rs2036263 chr7:65800197 C/T cg00343986 chr7:65444356 GUSB -0.4 -5.66 -0.3 3.3e-8 Aortic root size; CRC cis rs877282 0.797 rs7079164 chr10:756363 A/G cg17470449 chr10:769945 NA 0.61 7.96 0.4 2.78e-14 Uric acid levels; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg14097577 chr3:25824924 NGLY1 0.41 6.22 0.32 1.55e-9 Intelligence (multi-trait analysis); CRC cis rs9549260 0.755 rs7993233 chr13:41219434 T/A cg21288729 chr13:41239152 FOXO1 0.49 7.68 0.39 1.82e-13 Red blood cell count; CRC cis rs911555 0.755 rs8010247 chr14:103933556 A/G cg12935359 chr14:103987150 CKB 0.56 9.16 0.45 5.74e-18 Intelligence (multi-trait analysis); CRC cis rs2295359 1.000 rs9729046 chr1:67607082 C/G cg03340356 chr1:67600835 NA 0.24 5.61 0.3 4.41e-8 Psoriasis; CRC cis rs3540 0.574 rs2601205 chr15:90961813 A/G cg22089800 chr15:90895588 ZNF774 0.58 9.48 0.46 5.15e-19 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; CRC trans rs1814175 0.645 rs28445479 chr11:50047999 A/G cg15704280 chr7:45808275 SEPT13 -0.93 -17.08 -0.69 2.88e-47 Height; CRC cis rs67311347 1.000 rs9865348 chr3:40397658 A/C cg09455208 chr3:40491958 NA 0.44 8.79 0.44 8.17e-17 Renal cell carcinoma; CRC trans rs7395662 0.963 rs12418254 chr11:48988262 G/A cg21153622 chr11:89784906 NA -0.48 -7.72 -0.39 1.43e-13 HDL cholesterol; CRC trans rs1005277 0.579 rs176886 chr10:38403974 C/T cg27523141 chr10:43048294 ZNF37B 0.5 7.25 0.37 3.04e-12 Extrinsic epigenetic age acceleration; CRC cis rs2032447 0.610 rs189911 chr6:25965942 A/G cg12310025 chr6:25882481 NA -0.57 -8.07 -0.41 1.31e-14 Intelligence (multi-trait analysis); CRC cis rs9487051 0.807 rs1915835 chr6:109597483 C/T cg12927641 chr6:109611667 NA -0.36 -6.56 -0.34 2.09e-10 Reticulocyte fraction of red cells; CRC cis rs919433 0.680 rs6710530 chr2:198277551 G/A cg10820045 chr2:198174542 NA 0.38 6.24 0.33 1.34e-9 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC cis rs12760731 0.545 rs12032055 chr1:178567934 G/A cg00404053 chr1:178313656 RASAL2 0.56 6.82 0.35 4.45e-11 Obesity-related traits; CRC cis rs6860806 0.507 rs272868 chr5:131680751 C/G cg02033258 chr5:131593261 PDLIM4 0.38 6.44 0.33 4.21e-10 Breast cancer; CRC cis rs12760731 0.623 rs11584977 chr1:178387283 A/G cg00404053 chr1:178313656 RASAL2 0.74 9.19 0.45 4.56e-18 Obesity-related traits; CRC cis rs4820318 1 rs4820318 chr22:38570313 G/A cg25457927 chr22:38595422 NA -0.35 -7.02 -0.36 1.26e-11 Breast cancer; CRC trans rs11098499 0.954 rs11722872 chr4:120233030 G/C cg25214090 chr10:38739885 LOC399744 0.6 9.11 0.45 8.09e-18 Corneal astigmatism; CRC cis rs868036 1.000 rs9972436 chr15:68098027 G/C cg05925327 chr15:68127851 NA -0.31 -6.0 -0.31 5.18e-9 Restless legs syndrome; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg03672933 chr12:100661444 SCYL2;DEPDC4 0.39 6.37 0.33 6.21e-10 Liver disease severity in Alagille syndrome; CRC cis rs10911232 0.507 rs10797822 chr1:183017769 A/G ch.1.3577855R chr1:183094577 LAMC1 0.83 14.62 0.63 1.22e-37 Hypertriglyceridemia; CRC cis rs6867032 0.834 rs10043083 chr5:1995687 C/G cg26168224 chr5:2018326 NA -0.84 -14.29 -0.62 2.28e-36 Gut microbiome composition (winter); CRC cis rs7618915 0.547 rs2289250 chr3:52682946 A/C cg18404041 chr3:52824283 ITIH1 0.42 8.49 0.42 7.06e-16 Bipolar disorder; CRC cis rs62045849 0.557 rs12927059 chr16:89199205 G/A cg08015503 chr16:89190385 ACSF3 0.99 6.02 0.32 4.58e-9 Red blood cell count; CRC trans rs656319 0.647 rs13264668 chr8:9884877 C/T cg06636001 chr8:8085503 FLJ10661 -0.49 -7.24 -0.37 3.23e-12 Myopia (pathological); CRC cis rs11212617 0.935 rs664143 chr11:108225661 C/T cg14761454 chr11:108092087 ATM;NPAT -0.39 -5.69 -0.3 2.82e-8 Response to metformin in type 2 diabetes (glycemic); CRC cis rs881375 0.867 rs10818484 chr9:123661194 C/T cg00246817 chr9:123691163 NA -0.47 -6.0 -0.31 5.19e-9 Rheumatoid arthritis; CRC cis rs13191362 1.000 rs28360546 chr6:163210973 G/A cg06582575 chr6:163149167 PACRG;PARK2 0.89 11.11 0.52 1.48e-24 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs875971 0.830 rs6950137 chr7:65976610 G/A cg12463550 chr7:65579703 CRCP 0.49 6.85 0.35 3.65e-11 Aortic root size; CRC cis rs1670533 0.585 rs6827206 chr4:1065071 A/T cg27284194 chr4:1044797 NA 0.47 5.9 0.31 9.21e-9 Recombination rate (females); CRC cis rs10751667 0.961 rs6597954 chr11:987677 G/A cg23136738 chr11:925521 AP2A2 -0.48 -7.63 -0.39 2.49e-13 Alzheimer's disease (late onset); CRC cis rs78456975 0.527 rs11901028 chr2:1557972 A/G cg26248373 chr2:1572462 NA -0.8 -11.01 -0.52 3.36e-24 Placebo response in major depressive disorder (% change in symptom score); CRC cis rs9611565 0.649 rs202666 chr22:41814719 T/C cg03806693 chr22:41940476 POLR3H 1.03 12.95 0.58 2.89e-31 Vitiligo; CRC cis rs17376456 0.825 rs13361613 chr5:93272176 C/T cg09848695 chr5:92956644 FAM172A;MIR2277 0.68 6.03 0.32 4.45e-9 Diabetic retinopathy; CRC cis rs78456975 0.739 rs11891867 chr2:1517894 C/T cg12573674 chr2:1569213 NA -0.67 -7.74 -0.39 1.27e-13 Placebo response in major depressive disorder (% change in symptom score); CRC cis rs1005277 0.579 rs2472182 chr10:38388865 T/C cg25427524 chr10:38739819 LOC399744 -0.77 -13.64 -0.6 6.85e-34 Extrinsic epigenetic age acceleration; CRC cis rs4332037 0.539 rs62444881 chr7:2052318 C/T cg23378565 chr7:2036160 MAD1L1 -0.47 -6.62 -0.34 1.45e-10 Bipolar disorder; CRC trans rs877282 1.000 rs11253369 chr10:773610 C/G cg22713356 chr15:30763199 NA 0.93 12.29 0.56 8.22e-29 Uric acid levels; CRC cis rs11250464 0.517 rs2387668 chr10:1432003 C/T cg02408697 chr10:1416920 ADARB2 0.39 5.61 0.3 4.21e-8 Radiation response; CRC cis rs3617 0.625 rs7620690 chr3:52891707 A/G cg18099408 chr3:52552593 STAB1 0.35 6.04 0.32 4.2e-9 Red blood cell count;Autism spectrum disorder or schizophrenia; CRC cis rs10489202 0.608 rs35059151 chr1:168079393 C/A cg24449463 chr1:168025552 DCAF6 -0.51 -7.09 -0.36 8.3e-12 Schizophrenia; CRC cis rs4713118 0.629 rs203889 chr6:28021775 T/G cg12172441 chr6:28176163 NA 0.55 7.14 0.37 5.94e-12 Parkinson's disease; CRC cis rs3785888 0.553 rs10853086 chr17:45006109 A/G cg16759221 chr17:45003025 GOSR2 0.6 9.01 0.44 1.71e-17 Cleft lip with or without cleft palate; CRC cis rs10883723 0.810 rs1409311 chr10:104282160 G/A cg04362960 chr10:104952993 NT5C2 -0.4 -5.6 -0.3 4.46e-8 Allergic disease (asthma, hay fever or eczema); CRC cis rs4713118 0.662 rs149901 chr6:27965503 C/T cg23161317 chr6:28129485 ZNF389 0.47 6.64 0.34 1.28e-10 Parkinson's disease; CRC cis rs200986 1 rs200986 chr6:27824766 G/C cg08798685 chr6:27730294 NA -0.43 -6.33 -0.33 8.06e-10 Autism spectrum disorder or schizophrenia; CRC cis rs936229 0.861 rs11634474 chr15:75116184 C/G cg10253484 chr15:75165896 SCAMP2 -0.4 -5.75 -0.3 2.07e-8 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); CRC cis rs9303401 0.527 rs2116450 chr17:56745561 C/T cg10487724 chr17:56770010 TEX14;RAD51C 0.75 8.9 0.44 3.95e-17 Cognitive test performance; CRC cis rs7584330 0.617 rs10202195 chr2:238352128 A/G cg11271282 chr2:238384023 NA 0.45 5.63 0.3 3.85e-8 Prostate cancer; CRC cis rs1881797 1.000 rs10925062 chr1:247658978 G/C cg05639522 chr1:247681581 NA 0.49 7.09 0.36 8.43e-12 Acute lymphoblastic leukemia (childhood); CRC cis rs60871478 0.945 rs4719279 chr7:813618 T/C cg04727924 chr7:799746 HEATR2 -0.44 -6.54 -0.34 2.31e-10 Cerebrospinal P-tau181p levels; CRC trans rs10982213 0.830 rs2274163 chr9:117188714 C/T cg03558408 chr5:134181967 C5orf24 0.37 6.29 0.33 1.02e-9 Interleukin-6 levels; CRC cis rs10504229 1.000 rs3814486 chr8:58191226 A/T cg01721255 chr8:58191610 C8orf71 0.49 6.17 0.32 2e-9 Developmental language disorder (linguistic errors); CRC cis rs4919694 1.000 rs58317752 chr10:104799267 T/A cg04362960 chr10:104952993 NT5C2 1.13 10.63 0.51 6.83e-23 Arsenic metabolism; CRC cis rs66573146 0.901 rs55882710 chr4:7030704 G/A cg00086871 chr4:6988644 TBC1D14 0.83 6.46 0.34 3.68e-10 Granulocyte percentage of myeloid white cells; CRC cis rs7819412 0.775 rs2001329 chr8:10986859 C/T cg20542592 chr8:11973495 FAM66D 0.35 5.72 0.3 2.34e-8 Triglycerides; CRC cis rs9435341 0.929 rs1762509 chr1:107592959 A/G cg14828511 chr1:107599125 PRMT6 -0.57 -7.83 -0.4 6.95e-14 Facial morphology (factor 21, depth of nasal alae); CRC cis rs2493151 1.000 rs2493151 chr1:230878561 G/A cg07502417 chr1:230849801 AGT 0.29 5.9 0.31 8.83e-9 Blood protein levels; CRC cis rs4555082 0.830 rs2255575 chr14:105727251 T/C cg10792982 chr14:105748885 BRF1 0.37 6.19 0.32 1.75e-9 Mean platelet volume;Platelet distribution width; CRC cis rs2075371 0.897 rs12667905 chr7:134000812 A/C cg11752832 chr7:134001865 SLC35B4 0.45 6.62 0.34 1.42e-10 Mean platelet volume; CRC cis rs10504229 1.000 rs59383954 chr8:58189689 G/A cg24829409 chr8:58192753 C8orf71 -0.68 -11.34 -0.53 2.27e-25 Developmental language disorder (linguistic errors); CRC cis rs1018836 0.828 rs10956730 chr8:91597428 T/G cg16814680 chr8:91681699 NA -0.67 -10.24 -0.49 1.56e-21 Ejection fraction in Tripanosoma cruzi seropositivity; CRC cis rs6693567 0.565 rs11205370 chr1:150397567 A/G cg15654264 chr1:150340011 RPRD2 0.43 6.46 0.34 3.87e-10 Migraine; CRC cis rs734999 0.967 rs6667605 chr1:2502780 C/T cg18854424 chr1:2615690 NA 0.34 6.39 0.33 5.68e-10 Ulcerative colitis; CRC cis rs11122272 0.701 rs2749702 chr1:231523808 A/G cg06096015 chr1:231504339 EGLN1 0.4 5.98 0.31 5.78e-9 Hemoglobin concentration; CRC cis rs416603 0.967 rs7191538 chr16:11363389 C/G cg00044050 chr16:11439710 C16orf75 -0.56 -8.25 -0.41 3.8e-15 Type 1 diabetes; CRC cis rs6860806 0.507 rs272883 chr5:131668698 A/G cg11843238 chr5:131593191 PDLIM4 0.42 7.25 0.37 3.07e-12 Breast cancer; CRC cis rs4713118 0.513 rs156734 chr6:28007357 A/C cg15845792 chr6:28175446 NA 0.74 10.98 0.52 4.05e-24 Parkinson's disease; CRC cis rs2153535 0.580 rs6937186 chr6:8494493 A/C cg07606381 chr6:8435919 SLC35B3 0.67 10.76 0.51 2.49e-23 Motion sickness; CRC cis rs6585424 1.000 rs34162901 chr10:81946856 A/C cg11900509 chr10:81946545 ANXA11 -0.76 -9.15 -0.45 6.21e-18 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs2952156 0.920 rs2941506 chr17:37833035 A/G cg11212589 chr17:38028394 ZPBP2 0.35 6.25 0.33 1.24e-9 Asthma; CRC trans rs7618501 1.000 rs7374277 chr3:49784777 T/C cg21665057 chr3:196295764 WDR53;FBXO45 -0.86 -15.73 -0.66 5.59e-42 Intelligence (multi-trait analysis); CRC cis rs7523050 0.643 rs12741359 chr1:109400489 T/C cg08274380 chr1:109419600 GPSM2 0.84 6.6 0.34 1.69e-10 Fat distribution (HIV); CRC trans rs2228479 0.850 rs11639788 chr16:89807543 G/A cg24644049 chr4:85504048 CDS1 0.9 7.41 0.38 1.05e-12 Skin colour saturation; CRC cis rs7927771 0.524 rs10458915 chr11:47864392 T/A cg20307385 chr11:47447363 PSMC3 0.45 6.62 0.34 1.48e-10 Subjective well-being; CRC cis rs1129187 0.755 rs13215983 chr6:42924193 C/T cg09436375 chr6:42928200 GNMT -0.35 -6.58 -0.34 1.86e-10 Alzheimer's disease in APOE e4+ carriers; CRC cis rs651907 0.557 rs1056579 chr3:101397877 T/G cg11279151 chr3:101281821 RG9MTD1 -0.57 -7.74 -0.39 1.25e-13 Colorectal cancer; CRC cis rs2070997 1.000 rs6597645 chr9:133745487 A/G cg01000188 chr9:133769184 QRFP 0.55 7.08 0.36 8.55e-12 Response to amphetamines; CRC cis rs7258465 1.000 rs271624 chr19:18627953 A/G cg10790698 chr19:18539756 SSBP4 -0.46 -8.76 -0.43 1.06e-16 Breast cancer; CRC cis rs4604732 0.578 rs7525209 chr1:247627404 C/T cg12758973 chr1:247694275 LOC148824;OR2C3 0.42 6.14 0.32 2.32e-9 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CRC cis rs6499255 0.951 rs10454066 chr16:69699005 A/T cg15192750 chr16:69999425 NA 0.61 8.09 0.41 1.15e-14 IgE levels; CRC cis rs6499129 1.000 rs7185709 chr16:67529349 T/G cg26727032 chr16:67993705 SLC12A4 -0.54 -5.79 -0.3 1.62e-8 Waist-to-hip ratio adjusted for body mass index; CRC cis rs2011503 0.825 rs4808932 chr19:19358819 C/T cg11584989 chr19:19387371 SF4 0.49 6.08 0.32 3.24e-9 Bipolar disorder; CRC cis rs11148252 0.574 rs2038826 chr13:53280013 G/A cg20354231 chr13:53171401 NA -0.42 -6.69 -0.35 9.65e-11 Lewy body disease; CRC cis rs3785574 0.962 rs2955235 chr17:61966950 A/C cg06601766 chr17:61851465 DDX42;CCDC47 0.58 8.05 0.41 1.52e-14 Height; CRC cis rs1552244 0.832 rs3732968 chr3:10013273 A/G cg16606324 chr3:10149918 C3orf24 0.63 8.25 0.41 3.83e-15 Alzheimer's disease; CRC cis rs7692995 1.000 rs16896236 chr4:18003812 T/C cg08925142 chr4:18023851 LCORL -0.54 -6.03 -0.32 4.31e-9 Height; CRC cis rs853679 0.517 rs3173443 chr6:28137027 T/G cg12963246 chr6:28129442 ZNF389 0.49 5.7 0.3 2.71e-8 Depression; CRC cis rs73200209 0.744 rs2392967 chr12:116531742 T/C cg01776926 chr12:116560359 MED13L -0.61 -7.27 -0.37 2.72e-12 Total body bone mineral density; CRC cis rs4243830 0.850 rs57203351 chr1:6601319 T/C cg22792644 chr1:6614718 TAS1R1;NOL9 0.9 10.71 0.51 3.79e-23 Body mass index; CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg01668174 chr2:106810661 UXS1 -0.57 -6.9 -0.36 2.62e-11 Diisocyanate-induced asthma; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg24487784 chr11:696252 TMEM80;DEAF1 0.54 7.53 0.38 4.94e-13 Response to antipsychotic treatment; CRC cis rs7208859 0.673 rs73271887 chr17:29154935 T/C cg13385521 chr17:29058706 SUZ12P 0.65 7.4 0.38 1.15e-12 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs1552244 0.554 rs6443275 chr3:10008819 G/A cg13047869 chr3:10149882 C3orf24 0.38 5.97 0.31 6.27e-9 Alzheimer's disease; CRC cis rs7772486 0.754 rs6910790 chr6:146255330 G/A cg23711669 chr6:146136114 FBXO30 -0.71 -12.51 -0.57 1.25e-29 Lobe attachment (rater-scored or self-reported); CRC cis rs2836950 0.545 rs2836956 chr21:40623018 C/G cg11644478 chr21:40555479 PSMG1 0.44 6.34 0.33 7.37e-10 Menarche (age at onset); CRC cis rs9787249 0.957 rs7548120 chr1:40204424 A/T cg24920358 chr1:40204285 PPIE 0.56 8.37 0.42 1.62e-15 Blood protein levels; CRC cis rs4969178 0.896 rs1976704 chr17:76401318 C/T cg05887092 chr17:76393375 PGS1 0.56 9.99 0.48 1.03e-20 HDL cholesterol levels; CRC cis rs7666738 0.830 rs10516426 chr4:99035827 A/G cg17366294 chr4:99064904 C4orf37 0.44 7.47 0.38 7.18e-13 Colonoscopy-negative controls vs population controls; CRC cis rs3857067 0.806 rs12505596 chr4:95109600 A/G cg11021082 chr4:95130006 SMARCAD1 -0.49 -7.35 -0.38 1.62e-12 QT interval; CRC cis rs9902453 0.791 rs3115086 chr17:28025949 C/T cg26525008 chr17:28256777 EFCAB5;SSH2 0.7 11.56 0.54 3.48e-26 Coffee consumption (cups per day); CRC cis rs11122272 0.735 rs2808592 chr1:231523757 G/A cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.54 -8.14 -0.41 7.99e-15 Hemoglobin concentration; CRC cis rs2841277 0.708 rs4465542 chr14:105407798 A/G cg15352829 chr14:105391018 PLD4 -0.48 -10.64 -0.51 6.2e-23 Rheumatoid arthritis; CRC cis rs3106136 0.967 rs35670996 chr4:95199479 C/G cg11021082 chr4:95130006 SMARCAD1 -0.47 -7.37 -0.38 1.43e-12 Capecitabine sensitivity; CRC cis rs6951245 0.935 rs113365567 chr7:1108785 T/C cg22907277 chr7:1156413 C7orf50 0.74 7.87 0.4 5.03e-14 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs35110281 0.693 rs2838344 chr21:45089877 C/T cg01579765 chr21:45077557 HSF2BP -0.36 -6.94 -0.36 2.03e-11 Mean corpuscular volume; CRC cis rs2408955 0.500 rs12816820 chr12:48558325 A/G cg15465823 chr12:48382534 COL2A1 0.37 6.16 0.32 2.12e-9 Glycated hemoglobin levels; CRC cis rs17376456 0.825 rs13161885 chr5:93071242 A/C cg25358565 chr5:93447407 FAM172A 0.99 9.38 0.46 1.1e-18 Diabetic retinopathy; CRC trans rs6545883 0.965 rs1992765 chr2:61751333 A/G cg11704114 chr12:21509398 SLCO1A2 -0.32 -6.08 -0.32 3.25e-9 Tuberculosis; CRC cis rs780096 0.546 rs1647284 chr2:27608115 C/T cg22903471 chr2:27725779 GCKR -0.37 -6.08 -0.32 3.27e-9 Total body bone mineral density; CRC cis rs4666002 0.956 rs34502053 chr2:27854524 G/A cg27432699 chr2:27873401 GPN1 0.44 5.66 0.3 3.38e-8 Phospholipid levels (plasma); CRC cis rs1862618 0.853 rs190414 chr5:56116772 C/A cg24531977 chr5:56204891 C5orf35 -0.78 -10.6 -0.5 8.77e-23 Initial pursuit acceleration; CRC cis rs9902453 0.967 rs4994355 chr17:28386284 T/A cg26525008 chr17:28256777 EFCAB5;SSH2 -0.59 -8.78 -0.44 8.99e-17 Coffee consumption (cups per day); CRC cis rs1572438 0.868 rs9378518 chr6:861084 A/G cg13447295 chr6:887704 NA -0.45 -6.68 -0.35 1.01e-10 Aging; CRC trans rs1814175 0.630 rs1722019 chr11:49904102 G/A cg15704280 chr7:45808275 SEPT13 -0.75 -12.2 -0.56 1.64e-28 Height; CRC cis rs4974559 0.947 rs6847321 chr4:1347374 C/T cg02980000 chr4:1222292 CTBP1 0.76 10.06 0.49 6.06e-21 Systolic blood pressure; CRC trans rs11098499 0.754 rs12507565 chr4:120251121 G/A cg25214090 chr10:38739885 LOC399744 0.53 8.36 0.42 1.81e-15 Corneal astigmatism; CRC cis rs2439831 0.702 rs3759791 chr15:44090798 T/C cg02155558 chr15:43621948 ADAL;LCMT2 0.7 7.49 0.38 6.35e-13 Lung cancer in ever smokers; CRC cis rs782590 0.620 rs7596377 chr2:55888612 T/A cg18811423 chr2:55921094 PNPT1 -0.75 -11.75 -0.54 7.28e-27 Metabolic syndrome; CRC cis rs7954584 0.567 rs11043246 chr12:122368944 G/A cg21171335 chr12:122356390 WDR66 0.39 5.88 0.31 1.03e-8 Mean corpuscular volume; CRC cis rs3824867 0.920 rs9734013 chr11:47451517 G/T cg05585544 chr11:47624801 NA 0.41 6.23 0.33 1.4e-9 Mean corpuscular hemoglobin; CRC cis rs3218092 0.872 rs16895128 chr6:41924369 G/A cg17623882 chr6:41773611 USP49 0.49 5.95 0.31 6.95e-9 Red cell distribution width; CRC cis rs711245 0.574 rs1179494 chr2:36809496 C/G cg01206211 chr2:36825736 FEZ2 -0.43 -7.02 -0.36 1.27e-11 Height; CRC cis rs7527798 0.614 rs11118253 chr1:207825469 G/C cg09232269 chr1:207846808 CR1L -0.45 -7.31 -0.37 2.02e-12 Erythrocyte sedimentation rate; CRC cis rs116095464 0.558 rs1541822 chr5:269234 A/C cg22857025 chr5:266934 NA 1.23 16.47 0.67 7.5e-45 Breast cancer; CRC cis rs4478858 0.698 rs4949385 chr1:31793256 C/T cg00250761 chr1:31883323 NA -0.44 -8.36 -0.42 1.75e-15 Alcohol dependence; CRC cis rs738322 0.718 rs3761445 chr22:38595411 G/A cg25457927 chr22:38595422 NA 0.53 11.8 0.55 4.99e-27 Cutaneous nevi; CRC cis rs4665809 1.000 rs10170359 chr2:26272219 G/T cg27170947 chr2:26402098 FAM59B -0.46 -6.1 -0.32 2.96e-9 Gut microbiome composition (summer); CRC cis rs17376456 0.877 rs17316137 chr5:93456577 C/T cg21475434 chr5:93447410 FAM172A 0.78 8.25 0.41 3.88e-15 Diabetic retinopathy; CRC cis rs9487051 0.872 rs9487042 chr6:109610443 T/G cg12927641 chr6:109611667 NA -0.38 -6.97 -0.36 1.78e-11 Reticulocyte fraction of red cells; CRC cis rs4713118 0.629 rs203889 chr6:28021775 T/G cg06470822 chr6:28175283 NA 0.93 13.59 0.6 1.05e-33 Parkinson's disease; CRC trans rs9914544 0.564 rs12451220 chr17:18778421 C/T cg21372672 chr17:16614065 CCDC144A -0.38 -6.02 -0.31 4.74e-9 Educational attainment (years of education); CRC cis rs4509693 0.765 rs10786604 chr10:102495302 C/G cg23167259 chr10:102495509 NA -0.47 -5.87 -0.31 1.06e-8 Alzheimer's disease; CRC cis rs9322817 0.691 rs2486136 chr6:105285759 C/T cg02098413 chr6:105308735 HACE1 0.44 8.72 0.43 1.41e-16 Thyroid stimulating hormone; CRC cis rs6076065 0.723 rs2144381 chr20:23369940 C/T cg11657817 chr20:23433608 CST11 0.44 6.63 0.34 1.37e-10 Facial morphology (factor 15, philtrum width); CRC cis rs6540559 0.673 rs2357230 chr1:210019498 G/A cg22029157 chr1:209979665 IRF6 0.67 7.69 0.39 1.77e-13 Cleft lip with or without cleft palate; CRC cis rs801193 1.000 rs4279493 chr7:66226620 C/T cg25985355 chr7:65971099 NA -0.32 -5.62 -0.3 4.12e-8 Aortic root size; CRC cis rs853679 0.517 rs2281588 chr6:28072602 G/A cg18032046 chr6:28092343 ZSCAN16 -0.5 -5.84 -0.31 1.26e-8 Depression; CRC cis rs7615952 0.534 rs1503072 chr3:125754691 C/T cg02772935 chr3:125709198 NA -0.5 -5.71 -0.3 2.53e-8 Blood pressure (smoking interaction); CRC cis rs743757 1.000 rs734767 chr3:50431410 C/G cg08207895 chr3:50388901 TUSC4;CYB561D2 0.42 6.09 0.32 3.23e-9 Diastolic blood pressure; CRC cis rs13315871 1.000 rs35792042 chr3:58409668 C/T cg20936604 chr3:58311152 NA -0.76 -7.2 -0.37 4.22e-12 Cholesterol, total; CRC cis rs10046574 0.831 rs7810503 chr7:135142285 T/C cg27474649 chr7:135195673 CNOT4 0.69 5.72 0.3 2.41e-8 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs1559088 1.000 rs1559087 chr19:33551041 A/G cg27124370 chr19:33622961 WDR88 0.41 5.71 0.3 2.49e-8 Bone ultrasound measurement (broadband ultrasound attenuation); CRC cis rs6500602 0.627 rs9938228 chr16:4530597 T/C cg08645402 chr16:4508243 NA 0.54 7.95 0.4 2.99e-14 Schizophrenia; CRC cis rs79387448 0.745 rs1880000 chr2:103099953 T/C cg09003973 chr2:102972529 NA 0.67 7.28 0.37 2.51e-12 Gut microbiota (bacterial taxa); CRC cis rs7944584 0.655 rs11039183 chr11:47346940 G/A cg20307385 chr11:47447363 PSMC3 0.74 9.84 0.48 3.41e-20 Fasting blood glucose;Fasting blood glucose (BMI interaction); CRC cis rs13144136 0.687 rs12499294 chr4:10654086 T/C cg10242279 chr4:10666415 CLNK -0.37 -6.29 -0.33 1.02e-9 Resistance to antihypertensive treatment in hypertension; CRC cis rs748404 0.697 rs531910 chr15:43560607 A/G cg02155558 chr15:43621948 ADAL;LCMT2 0.41 6.18 0.32 1.95e-9 Lung cancer; CRC cis rs853679 1.000 rs853676 chr6:28299687 C/T cg03623178 chr6:28175578 NA 0.69 7.04 0.36 1.11e-11 Depression; CRC cis rs72627123 1.000 rs17093141 chr14:74326903 G/T cg19860245 chr14:74300557 NA -0.51 -5.61 -0.3 4.36e-8 Morning vs. evening chronotype; CRC cis rs11212617 1.000 rs2884030 chr11:108281903 C/T cg12106634 chr11:108092400 ATM;NPAT 0.44 6.63 0.34 1.42e-10 Response to metformin in type 2 diabetes (glycemic); CRC cis rs9916302 0.904 rs8066704 chr17:37477218 C/T cg03013999 chr17:37608204 MED1 -0.48 -7.47 -0.38 7.5e-13 Glomerular filtration rate (creatinine); CRC cis rs10256972 0.684 rs4724039 chr7:1111633 A/G cg03923535 chr7:1197113 ZFAND2A 0.53 7.6 0.39 3.03e-13 Longevity;Endometriosis; CRC cis rs2569991 0.588 rs14191 chr3:12940346 G/A cg22481960 chr3:13008800 IQSEC1 -0.5 -6.25 -0.33 1.26e-9 Periodontitis (DPAL); CRC cis rs747650 0.504 rs7114683 chr11:47077246 T/A cg19486271 chr11:47235900 DDB2 -0.44 -5.86 -0.31 1.11e-8 Acne (severe); CRC trans rs7267979 0.899 rs2104734 chr20:25526668 A/G cg17903999 chr18:56338584 MALT1 -0.42 -6.95 -0.36 1.97e-11 Liver enzyme levels (alkaline phosphatase); CRC cis rs4975616 0.869 rs466502 chr5:1325767 C/T cg26373071 chr5:1325741 CLPTM1L -0.54 -9.85 -0.48 3.21e-20 Lung cancer; CRC cis rs12586317 0.547 rs13379372 chr14:35483882 A/C cg16230307 chr14:35515116 FAM177A1 0.87 10.25 0.49 1.43e-21 Psoriasis; CRC cis rs3815700 1.000 rs8108840 chr19:33094452 A/C cg02997394 chr19:33096574 ANKRD27 0.75 8.98 0.44 2.09e-17 Eosinophilic esophagitis; CRC trans rs2243480 0.708 rs35825036 chr7:65986502 T/C cg10756647 chr7:56101905 PSPH 0.76 7.92 0.4 3.72e-14 Diabetic kidney disease; CRC cis rs4664308 0.810 rs62175552 chr2:160937220 T/G cg03641300 chr2:160917029 PLA2R1 -0.73 -11.66 -0.54 1.59e-26 Idiopathic membranous nephropathy; CRC cis rs4728302 0.583 rs1424583 chr7:133159583 T/G cg10665199 chr7:133106180 EXOC4 0.67 10.41 0.5 4.15e-22 Intelligence;Intelligence (multi-trait analysis); CRC cis rs6912958 0.535 rs242283 chr6:88030931 C/T cg04972856 chr6:88032051 C6orf162;GJB7 0.33 6.14 0.32 2.34e-9 Monocyte percentage of white cells; CRC cis rs143985986 1 rs143985986 chr3:58399886 TC/T cg06643156 chr3:58380774 PXK 0.41 5.92 0.31 7.96e-9 Hematocrit; CRC cis rs6831352 0.918 rs17218602 chr4:100061073 A/G cg13256891 chr4:100009986 ADH5 -0.65 -8.82 -0.44 6.89e-17 Alcohol dependence; CRC cis rs4237845 0.611 rs4583019 chr12:58316745 T/C cg02175503 chr12:58329896 NA 0.81 13.25 0.59 2.02e-32 Intelligence (multi-trait analysis); CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg25020728 chr12:123011538 RSRC2;KNTC1 0.48 6.05 0.32 3.88e-9 Thyroid stimulating hormone; CRC cis rs11764590 0.813 rs11768212 chr7:1992582 A/C cg23378565 chr7:2036160 MAD1L1 -0.44 -6.49 -0.34 3.12e-10 Neuroticism; CRC cis rs10751667 0.560 rs10902265 chr11:1003642 G/A ch.11.42038R chr11:967971 AP2A2 0.58 9.15 0.45 6.28e-18 Alzheimer's disease (late onset); CRC cis rs6499255 0.951 rs8054096 chr16:69695886 G/A cg00738113 chr16:70207722 CLEC18C -0.38 -5.62 -0.3 4.13e-8 IgE levels; CRC cis rs13064411 0.660 rs11916690 chr3:113012343 A/C cg18753928 chr3:113234510 CCDC52 -0.56 -7.47 -0.38 7.34e-13 Response to simvastatin treatment (PCSK9 protein level change); CRC cis rs847577 0.609 rs17435590 chr7:97784061 T/C cg24562669 chr7:97807699 LMTK2 0.79 17.7 0.7 1.05e-49 Breast cancer; CRC cis rs1008375 1.000 rs4698200 chr4:17657051 G/A cg16339924 chr4:17578868 LAP3 0.58 7.83 0.4 6.98e-14 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs62244186 0.659 rs7649834 chr3:44503732 C/T cg18165381 chr3:44552316 NA -0.38 -5.69 -0.3 2.8e-8 Depressive symptoms; CRC trans rs1005277 0.540 rs2145487 chr10:38010077 A/G cg23533926 chr12:111358616 MYL2 -0.44 -6.45 -0.34 3.98e-10 Extrinsic epigenetic age acceleration; CRC cis rs372883 0.638 rs371432 chr21:30710876 G/A cg08807101 chr21:30365312 RNF160 -0.51 -7.17 -0.37 4.88e-12 Pancreatic cancer; CRC cis rs798554 0.797 rs1182184 chr7:2872446 G/A cg19346786 chr7:2764209 NA -0.42 -7.26 -0.37 2.79e-12 Height; CRC cis rs780096 0.565 rs11681351 chr2:27743423 G/A cg21248554 chr2:27665150 KRTCAP3 -0.3 -6.48 -0.34 3.4e-10 Total body bone mineral density; CRC cis rs7474896 0.583 rs10827817 chr10:37997974 A/G cg25427524 chr10:38739819 LOC399744 -0.57 -7.11 -0.36 7.31e-12 Obesity (extreme); CRC cis rs3018066 0.867 rs7693448 chr4:107156635 T/C cg01869342 chr4:106983673 TBCK -0.36 -5.65 -0.3 3.45e-8 Cancer; CRC cis rs10479542 0.896 rs4701131 chr5:178982446 A/G cg09060608 chr5:178986726 RUFY1 0.55 9.85 0.48 3.11e-20 Lung cancer; CRC cis rs7662987 0.517 rs2851256 chr4:100039549 G/A cg12011299 chr4:100065546 ADH4 0.49 9.26 0.45 2.63e-18 Smoking initiation; CRC cis rs6840360 1.000 rs2303866 chr4:152640387 C/T cg09659197 chr4:152720779 NA 0.54 11.69 0.54 1.24e-26 Intelligence (multi-trait analysis); CRC cis rs853679 0.517 rs67878650 chr6:28142587 G/C cg12273811 chr6:28175739 NA 0.72 9.03 0.45 1.47e-17 Depression; CRC cis rs12188164 0.965 rs11739543 chr5:443676 G/A cg21972741 chr5:435613 AHRR 0.54 7.37 0.38 1.39e-12 Cystic fibrosis severity; CRC cis rs4727027 0.866 rs10435245 chr7:148816081 C/G cg23583168 chr7:148888333 NA -0.89 -15.09 -0.64 1.77e-39 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC cis rs1707322 0.752 rs3811435 chr1:46125790 C/A cg06784218 chr1:46089804 CCDC17 0.66 12.35 0.56 4.77e-29 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC trans rs9929218 0.954 rs35444713 chr16:68824492 C/T cg04657470 chr2:198365150 HSPE1;HSPD1 -0.82 -11.8 -0.55 4.81e-27 Colorectal cancer; CRC cis rs10504229 0.683 rs34859456 chr8:58117722 A/C cg24829409 chr8:58192753 C8orf71 -0.55 -8.03 -0.4 1.71e-14 Developmental language disorder (linguistic errors); CRC trans rs1945213 0.659 rs17149979 chr11:55840862 A/G cg15704280 chr7:45808275 SEPT13 0.55 6.15 0.32 2.25e-9 Acute lymphoblastic leukemia (childhood); CRC cis rs514406 0.861 rs4926577 chr1:53226788 C/A cg24675658 chr1:53192096 ZYG11B 0.53 7.8 0.39 8.34e-14 Monocyte count; CRC cis rs4077468 0.700 rs4951030 chr1:205913747 T/A cg13172432 chr1:205912842 SLC26A9 -0.34 -6.04 -0.32 4.25e-9 Cystic fibrosis-related diabetes; CRC cis rs912057 0.671 rs1294427 chr6:6744546 T/G cg06612196 chr6:6737390 NA 0.54 8.59 0.43 3.49e-16 Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction); CRC cis rs881375 0.933 rs7031096 chr9:123694942 T/C cg14255062 chr9:123606675 PSMD5;LOC253039 0.4 5.87 0.31 1.05e-8 Rheumatoid arthritis; CRC trans rs5756813 0.661 rs2285177 chr22:38205894 A/G cg19894588 chr14:64061835 NA -0.6 -8.31 -0.42 2.48e-15 Optic cup area;Vertical cup-disc ratio; CRC cis rs1348850 0.598 rs12616259 chr2:178503803 C/T cg02961200 chr2:178257176 LOC100130691;AGPS 0.62 8.72 0.43 1.39e-16 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs3785574 0.962 rs2584630 chr17:61887561 T/A cg06601766 chr17:61851465 DDX42;CCDC47 0.6 8.43 0.42 1.07e-15 Height; CRC cis rs798554 0.959 rs798558 chr7:2758935 T/G cg17321639 chr7:2759063 NA -0.55 -7.55 -0.38 4.29e-13 Height; CRC cis rs9814567 1.000 rs6763088 chr3:134254989 C/G cg06541857 chr3:134203789 ANAPC13;CEP63 0.39 5.74 0.3 2.15e-8 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC trans rs877282 0.891 rs12357999 chr10:796468 A/C cg22713356 chr15:30763199 NA 1.34 16.68 0.68 1.08e-45 Uric acid levels; CRC trans rs6550704 0.687 rs9865314 chr3:22634337 A/G cg10877050 chr13:100741041 PCCA -0.44 -6.46 -0.34 3.79e-10 Daytime sleep phenotypes; CRC cis rs12024301 0.557 rs10911413 chr1:183662791 C/T cg11505048 chr1:183622726 RGL1;APOBEC4 0.71 6.24 0.33 1.33e-9 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs6860806 0.507 rs272878 chr5:131671769 C/T cg07395648 chr5:131743802 NA 0.4 5.74 0.3 2.19e-8 Breast cancer; CRC trans rs9291683 0.588 rs13113730 chr4:10017628 C/T cg26043149 chr18:55253948 FECH 0.51 7.91 0.4 3.95e-14 Bone mineral density; CRC cis rs7258465 0.965 rs271628 chr19:18624333 A/G cg01065977 chr19:18549689 ISYNA1 -0.39 -6.16 -0.32 2.1e-9 Breast cancer; CRC cis rs2228479 0.867 rs62052185 chr16:89969254 C/T cg19635926 chr16:89946313 TCF25 0.67 6.88 0.35 3.12e-11 Skin colour saturation; CRC cis rs10504229 0.683 rs7816733 chr8:58129855 G/A cg22535103 chr8:58192502 C8orf71 -0.7 -9.34 -0.46 1.47e-18 Developmental language disorder (linguistic errors); CRC cis rs965469 1.000 rs6037583 chr20:3360632 G/A cg25506879 chr20:3388711 C20orf194 -0.4 -5.84 -0.31 1.28e-8 IFN-related cytopenia; CRC cis rs6840360 0.693 rs28622593 chr4:152374080 A/G cg09659197 chr4:152720779 NA 0.33 6.61 0.34 1.57e-10 Intelligence (multi-trait analysis); CRC cis rs10504229 1.000 rs57261109 chr8:58172152 C/T cg01721255 chr8:58191610 C8orf71 0.49 6.17 0.32 2e-9 Developmental language disorder (linguistic errors); CRC cis rs10504229 0.683 rs72649188 chr8:58108829 A/G cg02725872 chr8:58115012 NA -0.66 -11.36 -0.53 1.84e-25 Developmental language disorder (linguistic errors); CRC cis rs951366 0.789 rs1775154 chr1:205696615 T/A cg24503407 chr1:205819492 PM20D1 0.82 12.64 0.57 4.02e-30 Menarche (age at onset); CRC cis rs9372498 0.505 rs9489462 chr6:118927855 C/T cg15382696 chr6:118971807 C6orf204 0.59 7.43 0.38 9.32e-13 Diastolic blood pressure; CRC trans rs916888 0.610 rs199444 chr17:44818276 T/C cg01341218 chr17:43662625 NA 0.62 7.69 0.39 1.67e-13 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs10463316 0.608 rs13360453 chr5:150769143 T/C cg03212797 chr5:150827313 SLC36A1 -0.49 -7.8 -0.4 8.25e-14 Metabolite levels (Pyroglutamine); CRC cis rs10878977 0.542 rs11177653 chr12:69802927 C/T cg20891283 chr12:69753455 YEATS4 -0.57 -5.81 -0.3 1.5e-8 Colorectal cancer; CRC cis rs11105298 0.891 rs4842654 chr12:89834428 T/A cg00757033 chr12:89920650 WDR51B 0.37 6.19 0.32 1.8e-9 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; CRC cis rs3736485 0.816 rs8038341 chr15:51870748 G/C cg08986416 chr15:51914746 DMXL2 -0.48 -6.96 -0.36 1.88e-11 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs4731207 0.570 rs10954055 chr7:124589232 C/A cg23710748 chr7:124431027 NA -0.38 -6.08 -0.32 3.35e-9 Cutaneous malignant melanoma; CRC cis rs6867032 0.527 rs9312971 chr5:2012888 C/A cg26168224 chr5:2018326 NA 0.76 12.45 0.57 2e-29 Gut microbiome composition (winter); CRC trans rs7647973 0.710 rs11130208 chr3:49615624 G/T cg21659725 chr3:3221576 CRBN -0.69 -7.14 -0.37 6.11e-12 Menarche (age at onset); CRC cis rs1862618 0.802 rs7733041 chr5:56107377 A/C cg20203395 chr5:56204925 C5orf35 -0.67 -8.27 -0.41 3.3e-15 Initial pursuit acceleration; CRC cis rs12913538 0.513 rs12441930 chr15:62889367 C/G cg09983546 chr15:62884068 NA 0.42 5.89 0.31 9.62e-9 Sleep depth; CRC cis rs2073499 1.000 rs2073498 chr3:50369546 C/A cg09545109 chr3:50388910 TUSC4;CYB561D2 0.63 5.71 0.3 2.48e-8 Schizophrenia; CRC cis rs17189216 1.000 rs17189216 chr8:120448932 C/T cg27215916 chr8:120218354 NA 0.67 5.82 0.31 1.37e-8 Post bronchodilator FEV1/FVC ratio; CRC cis rs6502050 0.835 rs8081949 chr17:80117490 G/A cg22110888 chr17:80059540 CCDC57 0.4 6.48 0.34 3.37e-10 Life satisfaction; CRC cis rs3768617 0.510 rs10911243 chr1:183075415 G/A ch.1.3577855R chr1:183094577 LAMC1 0.87 15.46 0.65 6.33e-41 Fuchs's corneal dystrophy; CRC cis rs7666738 0.830 rs10001479 chr4:98918764 A/G cg05340658 chr4:99064831 C4orf37 -0.54 -7.91 -0.4 4.04e-14 Colonoscopy-negative controls vs population controls; CRC cis rs752010 0.631 rs4660549 chr1:42088102 A/G cg06885757 chr1:42089581 HIVEP3 0.68 11.6 0.54 2.51e-26 Lupus nephritis in systemic lupus erythematosus; CRC cis rs427941 0.703 rs201450 chr7:101739441 A/T cg06246474 chr7:101738831 CUX1 -0.46 -7.3 -0.37 2.18e-12 Plasma omega-3 polyunsaturated fatty acid level (eicosapentaenoic acid); CRC cis rs7666738 0.830 rs13118892 chr4:98968497 T/C cg05340658 chr4:99064831 C4orf37 0.6 9.45 0.46 6.71e-19 Colonoscopy-negative controls vs population controls; CRC cis rs7666738 0.830 rs6833822 chr4:98951354 G/A cg17366294 chr4:99064904 C4orf37 0.43 7.34 0.38 1.69e-12 Colonoscopy-negative controls vs population controls; CRC cis rs3741151 0.773 rs17310361 chr11:73233724 T/C cg17517138 chr11:73019481 ARHGEF17 0.83 7.49 0.38 6.51e-13 GIP levels in response to oral glucose tolerance test (120 minutes); CRC cis rs6951245 1.000 rs11763835 chr7:1094513 A/G cg18402987 chr7:1209562 NA 0.68 7.3 0.37 2.2e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs2160860 0.773 rs6474194 chr8:39800944 C/A cg11363097 chr8:39792086 IDO2 -0.45 -7.63 -0.39 2.55e-13 Blood metabolite levels; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg21989094 chr19:39421295 MRPS12;SARS2 0.56 7.54 0.38 4.55e-13 Thyroid stimulating hormone; CRC cis rs6570726 0.902 rs9390326 chr6:145791222 A/G cg23711669 chr6:146136114 FBXO30 -0.62 -10.53 -0.5 1.57e-22 Lobe attachment (rater-scored or self-reported); CRC trans rs11098499 0.629 rs28369518 chr4:120271630 T/C cg25214090 chr10:38739885 LOC399744 0.53 8.51 0.42 6.28e-16 Corneal astigmatism; CRC cis rs7647973 1.000 rs7648995 chr3:49438803 C/T cg20833759 chr3:49053208 WDR6;DALRD3 -0.55 -8.2 -0.41 5.38e-15 Menarche (age at onset); CRC cis rs2239547 0.657 rs12488303 chr3:52862003 G/A cg11645453 chr3:52864694 ITIH4 0.62 11.22 0.53 5.75e-25 Schizophrenia; CRC cis rs6963495 0.818 rs117907809 chr7:105168472 C/A cg13798780 chr7:105162888 PUS7 0.68 8.02 0.4 1.87e-14 Bipolar disorder (body mass index interaction); CRC cis rs9326248 0.817 rs6589598 chr11:117002403 A/G cg10130564 chr11:117069849 TAGLN 0.35 5.86 0.31 1.11e-8 Blood protein levels; CRC cis rs6893807 0.778 rs13174131 chr5:87959538 T/G cg09002922 chr5:87956389 LOC645323 -0.44 -5.65 -0.3 3.53e-8 Body mass index; CRC cis rs919433 0.680 rs2564383 chr2:198310862 A/G cg10820045 chr2:198174542 NA 0.38 6.38 0.33 6.03e-10 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC cis rs9400271 0.632 rs4427037 chr6:109585612 G/C cg01475377 chr6:109611718 NA -0.35 -6.01 -0.31 5.03e-9 Sum neutrophil eosinophil counts;Sum basophil neutrophil counts;White blood cell count;Neutrophil count;Myeloid white cell count;Granulocyte count; CRC cis rs4588572 0.643 rs10063319 chr5:77758425 T/C cg11547950 chr5:77652471 NA -0.53 -7.17 -0.37 4.9e-12 Triglycerides; CRC cis rs4972806 0.814 rs1446575 chr2:177047801 A/C cg10305451 chr2:177043427 NA 0.71 11.34 0.53 2.24e-25 IgG glycosylation; CRC cis rs11723261 0.582 rs3747693 chr4:124375 T/G cg12746427 chr4:53362 ZNF718;ZNF595 0.49 6.5 0.34 3e-10 Immune response to smallpox vaccine (IL-6); CRC cis rs832540 0.519 rs1445998 chr5:56268205 A/G cg12311346 chr5:56204834 C5orf35 -0.49 -7.72 -0.39 1.45e-13 Coronary artery disease; CRC cis rs597539 0.690 rs552517 chr11:68625286 T/G cg06112835 chr11:68658793 MRPL21 0.46 7.41 0.38 1.07e-12 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs3806843 0.648 rs2530233 chr5:140082876 A/G cg19875535 chr5:140030758 IK -0.62 -10.38 -0.5 5.13e-22 Depressive symptoms (multi-trait analysis); CRC cis rs6674176 0.660 rs12726706 chr1:44399942 G/A cg15962314 chr1:44399869 ARTN 0.32 6.26 0.33 1.2e-9 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Cognitive ability; CRC cis rs4253772 0.530 rs6008662 chr22:46713917 G/A cg03482458 chr22:46692211 CN5H6.4;GTSE1 0.59 7.73 0.39 1.3e-13 LDL cholesterol;Cholesterol, total; CRC cis rs6681460 0.899 rs499263 chr1:67179937 T/C cg02459107 chr1:67143332 SGIP1 0.36 6.06 0.32 3.76e-9 Presence of antiphospholipid antibodies; CRC cis rs8044995 0.563 rs56331745 chr16:68368770 G/T cg08314208 chr16:67682810 RLTPR -0.55 -5.61 -0.3 4.4e-8 Schizophrenia; CRC cis rs9322193 0.886 rs10872652 chr6:150096439 C/T cg00933542 chr6:150070202 PCMT1 0.28 5.63 0.3 3.86e-8 Lung cancer; CRC cis rs3736485 0.934 rs8036904 chr15:51861438 G/A cg08986416 chr15:51914746 DMXL2 -0.45 -6.56 -0.34 2.12e-10 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs6952808 0.624 rs60137119 chr7:2083664 A/G cg21782813 chr7:2030301 MAD1L1 0.56 9.43 0.46 7.65e-19 Bipolar disorder and schizophrenia; CRC cis rs6545883 0.542 rs2593628 chr2:61573287 T/A cg10580144 chr2:61372316 C2orf74 -0.35 -7.81 -0.4 7.8500000000000006e-14 Tuberculosis; CRC cis rs11229555 0.645 rs12290089 chr11:58176849 A/G cg15696309 chr11:58395628 NA -0.81 -10.45 -0.5 2.9e-22 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; CRC cis rs9399135 0.967 rs6923827 chr6:135335382 C/T cg24558204 chr6:135376177 HBS1L 0.49 7.67 0.39 1.92e-13 Red blood cell count; CRC cis rs2361718 0.501 rs8065486 chr17:78138196 A/G cg21238619 chr17:78079768 GAA 0.43 6.99 0.36 1.58e-11 Yeast infection; CRC cis rs4654899 0.897 rs59537090 chr1:21498737 C/T cg02927042 chr1:21476669 EIF4G3 -0.48 -7.58 -0.39 3.62e-13 Superior frontal gyrus grey matter volume; CRC cis rs11122272 0.735 rs910823 chr1:231498766 G/T cg06096015 chr1:231504339 EGLN1 0.39 5.93 0.31 7.87e-9 Hemoglobin concentration; CRC cis rs4604732 0.631 rs56704806 chr1:247626148 T/C cg02104434 chr1:247694406 LOC148824;OR2C3 0.6 8.85 0.44 5.65e-17 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg06295308 chr2:232575555 PTMA 0.43 6.04 0.32 4.26e-9 Response to antipsychotic treatment; CRC cis rs910316 1.000 rs876402 chr14:75601862 C/T cg03030879 chr14:75389066 RPS6KL1 0.44 6.88 0.35 3.04e-11 Height; CRC cis rs9399135 0.967 rs13199205 chr6:135286505 T/C cg24558204 chr6:135376177 HBS1L 0.49 7.68 0.39 1.88e-13 Red blood cell count; CRC cis rs2228479 0.850 rs2238531 chr16:89856217 C/G cg19635926 chr16:89946313 TCF25 0.65 6.09 0.32 3.17e-9 Skin colour saturation; CRC cis rs769267 0.930 rs6511038 chr19:19607564 A/C cg03709012 chr19:19516395 GATAD2A 0.73 11.32 0.53 2.66e-25 Tonsillectomy; CRC cis rs28386778 0.897 rs4968663 chr17:61835603 A/T cg06873352 chr17:61820015 STRADA 0.76 14.29 0.62 2.25e-36 Prudent dietary pattern; CRC trans rs4942242 0.659 rs1105586 chr13:44232633 C/T cg27382691 chr15:76552771 ETFA;TYRO3P 0.42 6.09 0.32 3.2e-9 Response to tocilizumab in rheumatoid arthritis; CRC cis rs4076764 0.958 rs10917748 chr1:163400377 T/C cg06092702 chr1:163392909 NA -0.61 -9.62 -0.47 1.84e-19 Motion sickness; CRC cis rs7474896 0.583 rs7071147 chr10:38003376 T/C cg25427524 chr10:38739819 LOC399744 -0.59 -7.45 -0.38 8.39e-13 Obesity (extreme); CRC cis rs7727544 0.735 rs2631370 chr5:131703776 T/C cg12564285 chr5:131593104 PDLIM4 -0.33 -5.88 -0.31 9.97e-9 Blood metabolite levels; CRC cis rs11148252 0.774 rs56033750 chr13:52747278 A/C cg02158880 chr13:53174818 NA 0.45 6.74 0.35 6.93e-11 Lewy body disease; CRC cis rs561341 0.714 rs111760509 chr17:30304320 A/G cg23018236 chr17:30244563 NA -0.66 -7.83 -0.4 6.59e-14 Hip circumference adjusted for BMI; CRC cis rs875971 0.660 rs3857686 chr7:66036191 C/T cg00343986 chr7:65444356 GUSB -0.5 -7.43 -0.38 9.64e-13 Aortic root size; CRC cis rs10193935 0.901 rs10202848 chr2:42515661 A/G cg27598129 chr2:42591480 NA -0.66 -7.61 -0.39 2.93e-13 Colonoscopy-negative controls vs population controls; CRC cis rs9990333 1.000 rs9990333 chr3:195827205 C/T cg12923728 chr3:195709715 SDHAP1 0.51 7.41 0.38 1.1e-12 Iron status biomarkers (transferrin levels);Iron status biomarkers (transferrin saturation); CRC trans rs264943 0.600 rs1836054 chr2:104095980 T/C cg24033067 chr14:24674799 TSSK4 -0.41 -6.01 -0.31 4.8e-9 HIV-1 viral setpoint; CRC cis rs734999 0.545 rs6666430 chr1:2698950 G/A cg18854424 chr1:2615690 NA 0.41 7.68 0.39 1.79e-13 Ulcerative colitis; CRC cis rs11758351 0.517 rs79958315 chr6:26221826 C/T cg01420254 chr6:26195488 NA 0.75 8.46 0.42 9.1e-16 Gout;Renal underexcretion gout; CRC cis rs4789693 0.938 rs8078595 chr17:80426988 G/T cg04308225 chr17:80449738 NA 0.52 6.96 0.36 1.87e-11 Glucocorticoid-induced osteonecrosis; CRC cis rs9534288 0.797 rs2806922 chr13:46518059 A/G cg15192986 chr13:46630673 CPB2 -0.62 -9.21 -0.45 3.84e-18 Blood protein levels; CRC cis rs2280381 0.510 rs1474176 chr16:86008814 A/G cg08215318 chr16:86016387 NA 0.42 6.62 0.34 1.44e-10 Rheumatoid arthritis; CRC cis rs9486719 1.000 rs12208011 chr6:96991105 G/A cg18709589 chr6:96969512 KIAA0776 -0.53 -5.98 -0.31 5.81e-9 Migraine;Coronary artery disease; CRC trans rs6500957 0.920 rs17648524 chr16:7459683 C/G cg16239906 chr20:35724590 RBL1 0.45 6.96 0.36 1.83e-11 Spherical equivalent (joint analysis main effects and education interaction); CRC cis rs3733585 0.699 rs7657340 chr4:9966772 A/T cg00071950 chr4:10020882 SLC2A9 -0.55 -9.63 -0.47 1.67e-19 Cleft plate (environmental tobacco smoke interaction); CRC cis rs8072100 0.512 rs3809863 chr17:45385012 C/T cg08085267 chr17:45401833 C17orf57 -0.75 -13.27 -0.59 1.71e-32 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs9926296 0.585 rs4785595 chr16:89835521 C/T cg27121462 chr16:89883253 FANCA -0.56 -8.74 -0.43 1.2e-16 Vitiligo; CRC cis rs1448094 0.817 rs10863121 chr12:86343834 A/C cg18827107 chr12:86230957 RASSF9 0.44 6.96 0.36 1.88e-11 Major depressive disorder; CRC cis rs12936587 0.535 rs8065154 chr17:17614947 A/G cg09796270 chr17:17721594 SREBF1 0.41 6.88 0.35 3.12e-11 Hip circumference;Coronary artery disease or large artery stroke;Coronary heart disease;Coronary artery disease; CRC cis rs8062405 1.000 rs62036620 chr16:28833097 A/G cg16576597 chr16:28551801 NUPR1 0.49 7.07 0.36 9.42e-12 Cognitive ability (multi-trait analysis);Cognitive ability; CRC trans rs2303319 0.504 rs1023835 chr2:162593973 A/G cg22922770 chr7:98923339 ARPC1A -0.67 -5.98 -0.31 5.68e-9 Cognitive function; CRC cis rs514406 0.729 rs534070 chr1:53308858 T/G cg25767906 chr1:53392781 SCP2 -0.53 -8.41 -0.42 1.28e-15 Monocyte count; CRC cis rs9303280 0.806 rs9303279 chr17:38073968 G/C cg17467752 chr17:38218738 THRA 0.41 5.9 0.31 9e-9 Self-reported allergy; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg26858605 chr17:45771108 NA 0.52 7.52 0.38 5.14e-13 Response to antipsychotic treatment; CRC trans rs7647973 0.626 rs1996663 chr3:49878264 C/G cg21665057 chr3:196295764 WDR53;FBXO45 0.63 7.19 0.37 4.3e-12 Menarche (age at onset); CRC cis rs2739330 0.731 rs4822450 chr22:24242887 C/T cg11060661 chr22:24314208 DDT;DDTL 0.48 8.1 0.41 1.09e-14 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs8062405 0.964 rs11860513 chr16:28825420 C/T cg08761264 chr16:28874980 SH2B1 -0.43 -5.72 -0.3 2.4e-8 Cognitive ability (multi-trait analysis);Cognitive ability; CRC cis rs6952808 0.792 rs35582663 chr7:1948756 G/A cg22963979 chr7:1858916 MAD1L1 -0.51 -7.35 -0.38 1.57e-12 Bipolar disorder and schizophrenia; CRC cis rs10256972 0.621 rs2280725 chr7:1087426 G/T cg16145915 chr7:1198662 ZFAND2A -0.33 -6.43 -0.33 4.41e-10 Longevity;Endometriosis; CRC cis rs9894429 0.671 rs6565616 chr17:79612161 C/T cg18240062 chr17:79603768 NPLOC4 0.46 7.33 0.37 1.81e-12 Eye color traits; CRC cis rs7131987 0.874 rs10843366 chr12:29407903 T/C cg09582351 chr12:29534625 ERGIC2 -0.32 -6.82 -0.35 4.48e-11 QT interval; CRC cis rs9811920 0.609 rs809415 chr3:99582242 G/T cg07805332 chr3:99536008 MIR548G;C3orf26 0.52 7.72 0.39 1.42e-13 Axial length; CRC trans rs8073060 0.516 rs2376177 chr17:33938089 T/G cg19694781 chr19:47549865 TMEM160 -1.07 -15.45 -0.65 6.9e-41 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; CRC cis rs4908760 0.965 rs10864356 chr1:8569871 A/T cg20416874 chr1:8611966 RERE -0.45 -6.45 -0.33 4.03e-10 Vitiligo; CRC cis rs2153535 0.504 rs5001323 chr6:8451605 C/T cg21535247 chr6:8435926 SLC35B3 0.49 7.38 0.38 1.31e-12 Motion sickness; CRC cis rs11098499 0.863 rs3733525 chr4:120447048 A/G cg09307838 chr4:120376055 NA 0.69 10.33 0.5 7.26e-22 Corneal astigmatism; CRC cis rs9457247 0.967 rs385460 chr6:167403888 A/T cg23791538 chr6:167370224 RNASET2 -0.38 -5.94 -0.31 7.32e-9 Crohn's disease; CRC cis rs3771570 1.000 rs6752050 chr2:242228780 T/C cg21155796 chr2:242212141 HDLBP 0.64 6.95 0.36 1.95e-11 Prostate cancer; CRC cis rs1707322 0.721 rs10890341 chr1:46147240 C/A cg03146154 chr1:46216737 IPP 0.66 9.65 0.47 1.44e-19 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs34779708 0.736 rs34195979 chr10:35549817 T/C cg03585969 chr10:35415529 CREM 0.5 6.39 0.33 5.83e-10 Inflammatory bowel disease;Crohn's disease; CRC cis rs75804782 0.581 rs72987336 chr2:239365345 T/C cg18131467 chr2:239335373 ASB1 -0.65 -5.67 -0.3 3.2e-8 Morning vs. evening chronotype;Chronotype; CRC cis rs7044106 0.615 rs10818470 chr9:123359204 A/C cg09586646 chr9:123605570 PSMD5;LOC253039 0.53 7.64 0.39 2.39e-13 Hip circumference adjusted for BMI; CRC cis rs1552244 0.608 rs6764807 chr3:9998803 T/C cg00166722 chr3:10149974 C3orf24 0.42 6.26 0.33 1.22e-9 Alzheimer's disease; CRC cis rs17270561 0.636 rs6456697 chr6:25741434 A/G cg17691542 chr6:26056736 HIST1H1C 0.72 9.24 0.45 3.07e-18 Iron status biomarkers; CRC cis rs9326248 0.648 rs11216257 chr11:116932561 C/T cg11861562 chr11:117069780 TAGLN 0.33 6.23 0.32 1.45e-9 Blood protein levels; CRC cis rs1008375 1.000 rs10019856 chr4:17615742 T/A cg16339924 chr4:17578868 LAP3 0.52 6.89 0.36 2.81e-11 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs853679 0.517 rs9393894 chr6:28112562 A/G cg12273811 chr6:28175739 NA 0.73 9.16 0.45 5.8e-18 Depression; CRC cis rs7264396 0.790 rs1040695 chr20:34244829 T/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.59 -9.84 -0.48 3.48e-20 Total cholesterol levels; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg23396974 chr7:45151349 TBRG4 0.36 6.13 0.32 2.58e-9 Liver disease severity in Alagille syndrome; CRC cis rs2267708 0.506 rs1842616 chr7:124582172 G/C cg23710748 chr7:124431027 NA -0.38 -6.08 -0.32 3.25e-9 Chronic lymphocytic leukemia; CRC cis rs7804356 0.906 rs73069540 chr7:26904770 C/T cg03456212 chr7:26904342 SKAP2 -0.53 -5.93 -0.31 7.6e-9 Type 1 diabetes; CRC trans rs2243480 1.000 rs778729 chr7:65824419 T/C cg10756647 chr7:56101905 PSPH 0.78 8.03 0.4 1.75e-14 Diabetic kidney disease; CRC cis rs10504229 0.511 rs16921553 chr8:57979314 T/C cg02725872 chr8:58115012 NA -0.43 -6.37 -0.33 6.2e-10 Developmental language disorder (linguistic errors); CRC trans rs7267979 0.966 rs2500417 chr20:25383287 A/G cg17903999 chr18:56338584 MALT1 0.42 6.86 0.35 3.5e-11 Liver enzyme levels (alkaline phosphatase); CRC cis rs1153858 1.000 rs11858495 chr15:45637662 A/G cg21132104 chr15:45694354 SPATA5L1 -0.56 -7.98 -0.4 2.39e-14 Homoarginine levels; CRC cis rs10461617 0.541 rs832575 chr5:56161787 C/T cg03609598 chr5:56110824 MAP3K1 -0.62 -6.01 -0.31 4.85e-9 Type 2 diabetes; CRC cis rs10256972 0.681 rs12702016 chr7:1129392 C/T cg18765753 chr7:1198926 ZFAND2A -0.37 -6.37 -0.33 6.47e-10 Longevity;Endometriosis; CRC cis rs6541297 0.938 rs1555289 chr1:230292499 C/T cg20703242 chr1:230279135 GALNT2 -0.48 -6.84 -0.35 3.95e-11 Coronary artery disease; CRC trans rs10982213 0.830 rs2274163 chr9:117188714 C/T cg15198335 chr15:66586003 DIS3L 0.38 6.0 0.31 5.25e-9 Interleukin-6 levels; CRC cis rs2425143 0.915 rs74355238 chr20:34441541 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.5 -5.73 -0.3 2.23e-8 Blood protein levels; CRC cis rs7666738 0.822 rs28367231 chr4:98845726 G/T cg05340658 chr4:99064831 C4orf37 0.55 7.98 0.4 2.47e-14 Colonoscopy-negative controls vs population controls; CRC cis rs7959452 0.590 rs6581889 chr12:69757429 T/C cg20891283 chr12:69753455 YEATS4 0.91 17.38 0.69 1.84e-48 Blood protein levels; CRC cis rs7619833 0.512 rs7653795 chr3:27217080 G/A cg02860705 chr3:27208620 NA 0.39 5.99 0.31 5.54e-9 Breast cancer; CRC cis rs1707322 0.685 rs28617418 chr1:46189526 T/A cg03146154 chr1:46216737 IPP 0.68 9.94 0.48 1.59e-20 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs728616 0.717 rs12414332 chr10:81840955 C/T cg05935833 chr10:81318306 SFTPA2 -0.55 -6.55 -0.34 2.18e-10 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs2797160 0.837 rs1739364 chr6:126022383 A/G cg05901451 chr6:126070800 HEY2 -0.43 -6.57 -0.34 2e-10 Endometrial cancer; CRC cis rs9291683 0.575 rs3756223 chr4:10105797 C/T cg11266682 chr4:10021025 SLC2A9 0.39 7.63 0.39 2.62e-13 Bone mineral density; CRC cis rs7552404 0.731 rs5745458 chr1:76345429 G/A cg03433033 chr1:76189801 ACADM -0.68 -8.4 -0.42 1.35e-15 Blood metabolite levels;Acylcarnitine levels; CRC cis rs13108904 0.837 rs4591539 chr4:1279938 G/C cg16405210 chr4:1374714 KIAA1530 -0.44 -5.94 -0.31 7.23e-9 Obesity-related traits; CRC cis rs7635838 0.892 rs9836167 chr3:11493392 C/T cg00170343 chr3:11313890 ATG7 0.43 6.61 0.34 1.55e-10 HDL cholesterol; CRC cis rs1552244 0.554 rs6443275 chr3:10008819 G/A cg18598329 chr3:10140678 FANCD2;C3orf24 -0.52 -7.46 -0.38 7.81e-13 Alzheimer's disease; CRC cis rs13191362 0.935 rs67368176 chr6:162968436 A/T cg21926612 chr6:163149169 PACRG;PARK2 0.85 10.74 0.51 3e-23 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs6502050 0.805 rs11651863 chr17:80084539 T/C cg13198984 chr17:80129470 CCDC57 -0.49 -8.7 -0.43 1.67e-16 Life satisfaction; CRC cis rs3858526 0.920 rs11511938 chr11:5928793 A/G cg13902645 chr11:5959945 NA -0.62 -8.67 -0.43 1.94e-16 DNA methylation (variation); CRC cis rs2243480 0.614 rs34032527 chr7:65565141 C/G cg12463550 chr7:65579703 CRCP 0.68 6.55 0.34 2.22e-10 Diabetic kidney disease; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg18865796 chr19:11457210 TMEM205;CCDC159 0.44 7.05 0.36 1.03e-11 Liver disease severity in Alagille syndrome; CRC cis rs13095912 0.785 rs6807927 chr3:185324933 A/G cg11274856 chr3:185301563 NA -0.38 -5.65 -0.3 3.55e-8 Systolic blood pressure; CRC cis rs2304069 0.545 rs4705404 chr5:149381952 A/C cg12661370 chr5:149340060 SLC26A2 0.43 6.12 0.32 2.6e-9 HIV-1 control; CRC cis rs7615952 0.673 rs34209763 chr3:125599595 G/A cg05084668 chr3:125655381 ALG1L -0.72 -9.2 -0.45 4.26e-18 Blood pressure (smoking interaction); CRC cis rs11971779 0.680 rs4077889 chr7:139033914 A/G cg23387468 chr7:139079360 LUC7L2 0.41 7.14 0.37 6.12e-12 Diisocyanate-induced asthma; CRC cis rs7937682 0.889 rs2850247 chr11:111637202 C/A cg19812747 chr11:111475976 SIK2 0.47 7.82 0.4 7.26e-14 Primary sclerosing cholangitis; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg00455883 chr3:73046007 PPP4R2 -0.45 -6.65 -0.34 1.19e-10 Myopia (pathological); CRC cis rs1005277 0.579 rs2505237 chr10:38438898 T/G cg00409905 chr10:38381863 ZNF37A -0.65 -10.9 -0.52 8e-24 Extrinsic epigenetic age acceleration; CRC cis rs11711311 1.000 rs13070720 chr3:113473754 C/T cg15478005 chr3:113465772 ATP6V1A;NAA50 0.42 5.82 0.31 1.4e-8 IgG glycosylation; CRC cis rs1003719 0.762 rs6517402 chr21:38447423 A/C cg10648535 chr21:38446584 PIGP;TTC3 0.53 7.58 0.39 3.56e-13 Eye color traits; CRC cis rs8063761 1.000 rs8063761 chr16:90027626 A/T cg12064134 chr16:90016061 DEF8 0.62 9.68 0.47 1.16e-19 Squamous cell carcinoma; CRC cis rs4862750 0.872 rs9998173 chr4:187898778 T/A cg07414643 chr4:187882934 NA 0.38 6.68 0.35 9.92e-11 Lobe attachment (rater-scored or self-reported); CRC cis rs6502050 0.871 rs8072702 chr17:80074280 C/T cg02741985 chr17:80059408 CCDC57 -0.45 -7.43 -0.38 9.56e-13 Life satisfaction; CRC cis rs1129187 0.935 rs9986447 chr6:42942779 C/T cg10862848 chr6:42927986 GNMT 0.37 8.5 0.42 6.58e-16 Alzheimer's disease in APOE e4+ carriers; CRC trans rs360798 0.512 rs12989754 chr2:63020970 A/G cg05376469 chr2:102649931 NA 0.37 6.03 0.32 4.36e-9 Coronary artery disease; CRC cis rs1448094 0.935 rs10746355 chr12:86330227 A/T cg02569458 chr12:86230093 RASSF9 0.36 6.15 0.32 2.21e-9 Major depressive disorder; CRC cis rs875971 0.862 rs778680 chr7:65840414 G/A cg18252515 chr7:66147081 NA -0.41 -5.94 -0.31 7.15e-9 Aortic root size; CRC cis rs10504229 0.683 rs61241336 chr8:58106585 A/G cg22535103 chr8:58192502 C8orf71 -0.69 -8.8 -0.44 7.79e-17 Developmental language disorder (linguistic errors); CRC cis rs243505 0.559 rs10215159 chr7:148479071 G/C cg09806900 chr7:148480153 CUL1 0.61 8.77 0.44 9.8e-17 Inflammatory bowel disease;Crohn's disease; CRC cis rs2549003 1.000 rs7735073 chr5:131815357 G/A cg00255919 chr5:131827918 IRF1 0.59 11.92 0.55 1.8e-27 Asthma (sex interaction); CRC cis rs7772486 0.790 rs4075694 chr6:146251108 G/C cg13319975 chr6:146136371 FBXO30 0.44 6.62 0.34 1.49e-10 Lobe attachment (rater-scored or self-reported); CRC cis rs7772486 0.743 rs1292339 chr6:145967086 C/T cg13319975 chr6:146136371 FBXO30 0.38 5.65 0.3 3.48e-8 Lobe attachment (rater-scored or self-reported); CRC cis rs13191362 0.935 rs34009353 chr6:163007668 T/G cg23758597 chr6:163146217 PARK2 -0.51 -5.9 -0.31 8.81e-9 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs950776 0.518 rs12900783 chr15:78815523 G/A cg23880581 chr15:78912387 CHRNA3 0.33 5.63 0.3 3.92e-8 Sudden cardiac arrest; CRC cis rs7772486 0.875 rs1412081 chr6:146409733 A/G cg13319975 chr6:146136371 FBXO30 -0.39 -5.92 -0.31 8.13e-9 Lobe attachment (rater-scored or self-reported); CRC trans rs2303319 0.504 rs12467279 chr2:162544744 A/G cg14875682 chr5:52083620 ITGA1;PELO -0.76 -6.16 -0.32 2.13e-9 Cognitive function; CRC cis rs941408 0.515 rs1640262 chr19:2779134 C/T cg06609049 chr19:2785107 THOP1 -0.94 -16.46 -0.67 8.07e-45 Total cholesterol levels; CRC cis rs460214 0.528 rs6517474 chr21:40023133 G/A cg05519781 chr21:40033154 ERG -0.42 -5.73 -0.3 2.21e-8 Response to cognitive-behavioural therapy in anxiety disorder; CRC cis rs6502050 0.626 rs11868521 chr17:80100195 T/G cg02741985 chr17:80059408 CCDC57 -0.47 -7.61 -0.39 2.86e-13 Life satisfaction; CRC cis rs67478160 0.619 rs12897150 chr14:104319530 A/T cg01849466 chr14:104193079 ZFYVE21 -0.46 -7.9 -0.4 4.22e-14 Schizophrenia; CRC cis rs6901250 0.851 rs6938235 chr6:117147946 G/T cg12892004 chr6:117198278 RFX6 0.45 7.01 0.36 1.37e-11 C-reactive protein levels; CRC trans rs1899951 1.000 rs1899951 chr3:12394840 A/G cg04083076 chr1:169452126 SLC19A2 0.47 6.08 0.32 3.42e-9 Body mass index; CRC cis rs4664293 0.967 rs12999124 chr2:160531328 A/G cg08347373 chr2:160653686 CD302 -0.44 -7.1 -0.36 7.75e-12 Monocyte percentage of white cells; CRC cis rs6456156 0.792 rs7775443 chr6:167513252 A/C cg07513332 chr6:167530253 CCR6 -0.37 -6.1 -0.32 2.94e-9 Primary biliary cholangitis; CRC cis rs4727027 0.866 rs2373437 chr7:148779032 T/C cg12479418 chr7:148823350 ZNF425;ZNF398 0.46 6.3 0.33 9.48e-10 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC cis rs10504229 1.000 rs34616626 chr8:58184650 C/T cg01721255 chr8:58191610 C8orf71 0.49 6.17 0.32 2e-9 Developmental language disorder (linguistic errors); CRC cis rs8141529 0.764 rs5752809 chr22:29225500 G/A cg02153584 chr22:29168773 CCDC117 0.52 7.75 0.39 1.16e-13 Lymphocyte counts; CRC cis rs9786986 0.764 rs10925930 chr1:235696940 A/G cg08848088 chr1:235714526 GNG4 0.5 5.84 0.31 1.24e-8 Body mass index; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg00530939 chr1:51425360 FAF1 0.41 6.44 0.33 4.34e-10 Liver disease severity in Alagille syndrome; CRC cis rs13118159 0.801 rs13147602 chr4:1332175 A/G cg23123621 chr4:1343375 KIAA1530 0.38 6.43 0.33 4.55e-10 Longevity; CRC cis rs2415984 0.600 rs72672853 chr14:46932920 T/G cg14871534 chr14:47121158 RPL10L -0.42 -5.97 -0.31 6.01e-9 Number of children ever born; CRC cis rs4862750 0.914 rs1346127 chr4:187876389 C/T cg11301795 chr4:187892539 NA 0.82 17.75 0.7 6.42e-50 Lobe attachment (rater-scored or self-reported); CRC cis rs4363385 0.720 rs11205150 chr1:152959266 C/T cg25856811 chr1:152973957 SPRR3 -0.26 -7.12 -0.37 6.69e-12 Inflammatory skin disease; CRC trans rs12210905 1.000 rs9368494 chr6:27237301 C/T cg05005425 chr1:167687389 NA 0.62 6.33 0.33 8.22e-10 Hip circumference adjusted for BMI; CRC cis rs7666738 0.830 rs1534318 chr4:98965058 C/T cg17366294 chr4:99064904 C4orf37 0.43 7.24 0.37 3.23e-12 Colonoscopy-negative controls vs population controls; CRC cis rs7932354 0.528 rs7937950 chr11:47098445 A/C cg19486271 chr11:47235900 DDB2 -0.45 -6.57 -0.34 2.02e-10 Bone mineral density (hip);Bone mineral density; CRC trans rs4378999 0.528 rs4485709 chr3:50776497 G/T cg12383621 chr7:7735611 RPA3 -0.48 -6.05 -0.32 3.92e-9 Waist circumference adjusted for BMI in non-smokers;Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction); CRC cis rs10751667 0.666 rs7934963 chr11:957220 C/T cg06064525 chr11:970664 AP2A2 -0.34 -6.95 -0.36 1.98e-11 Alzheimer's disease (late onset); CRC cis rs826838 1.000 rs11168218 chr12:38884466 A/G cg13010199 chr12:38710504 ALG10B 0.46 6.01 0.31 4.91e-9 Heart rate; CRC cis rs7945705 0.902 rs11042088 chr11:8843515 T/A cg14711859 chr11:8959438 ASCL3 -0.45 -7.01 -0.36 1.38e-11 Hemoglobin concentration; CRC cis rs10504229 1.000 rs73607863 chr8:58170178 A/G cg24829409 chr8:58192753 C8orf71 -0.68 -11.34 -0.53 2.27e-25 Developmental language disorder (linguistic errors); CRC cis rs7493 0.755 rs17166859 chr7:94995519 T/C cg21856205 chr7:94953877 PON1 -0.45 -5.81 -0.31 1.47e-8 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs7193541 0.684 rs4887783 chr16:74700743 G/C cg01733217 chr16:74700730 RFWD3 1.07 23.95 0.8 4.29e-74 Multiple myeloma; CRC cis rs13191362 0.935 rs67368176 chr6:162968436 A/T cg23758597 chr6:163146217 PARK2 -0.59 -5.91 -0.31 8.72e-9 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs561341 1.000 rs56903735 chr17:30254393 T/A cg00745463 chr17:30367425 LRRC37B -0.68 -8.26 -0.41 3.61e-15 Hip circumference adjusted for BMI; CRC cis rs9858542 1.000 rs9823546 chr3:49705512 T/A cg03060546 chr3:49711283 APEH -0.53 -7.25 -0.37 2.99e-12 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs637571 0.546 rs10791827 chr11:65596546 C/A cg26695010 chr11:65641043 EFEMP2 0.51 7.62 0.39 2.66e-13 Eosinophil percentage of white cells; CRC cis rs7107174 1.000 rs10899474 chr11:78043636 T/C cg02023728 chr11:77925099 USP35 0.5 7.57 0.39 3.7e-13 Testicular germ cell tumor; CRC cis rs11098499 0.863 rs7669520 chr4:120515278 T/C cg09307838 chr4:120376055 NA 0.68 10.17 0.49 2.69e-21 Corneal astigmatism; CRC cis rs9287719 0.614 rs10929681 chr2:10723283 C/T cg00105475 chr2:10696890 NA 0.44 7.0 0.36 1.43e-11 Prostate cancer; CRC cis rs11971779 0.616 rs6967932 chr7:139022381 C/T cg23387468 chr7:139079360 LUC7L2 0.4 7.04 0.36 1.16e-11 Diisocyanate-induced asthma; CRC cis rs10504229 0.639 rs2318145 chr8:58114867 A/G cg22535103 chr8:58192502 C8orf71 -0.69 -9.23 -0.45 3.37e-18 Developmental language disorder (linguistic errors); CRC cis rs861020 0.771 rs126280 chr1:210019824 A/G cg05527609 chr1:210001259 C1orf107 0.99 13.53 0.6 1.81e-33 Orofacial clefts; CRC trans rs6076960 0.652 rs6085467 chr20:6259004 T/C cg21095983 chr6:86352623 SYNCRIP 0.52 7.59 0.39 3.26e-13 Smooth-surface caries; CRC cis rs1865760 1.000 rs2071298 chr6:25914901 G/A cg17691542 chr6:26056736 HIST1H1C 0.56 8.47 0.42 8.18e-16 Height; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg03216991 chr17:2415620 METT10D 0.37 6.05 0.32 3.99e-9 Liver disease severity in Alagille syndrome; CRC cis rs28386778 0.863 rs6919 chr17:61909485 A/T cg00280220 chr17:61926910 NA -0.33 -5.67 -0.3 3.16e-8 Prudent dietary pattern; CRC cis rs60871478 1.000 rs62432861 chr7:807649 G/A cg05535760 chr7:792225 HEATR2 0.8 10.54 0.5 1.38e-22 Cerebrospinal P-tau181p levels; CRC cis rs10751667 1.000 rs10902246 chr11:953674 T/C cg23136738 chr11:925521 AP2A2 -0.51 -8.26 -0.41 3.66e-15 Alzheimer's disease (late onset); CRC cis rs9457247 0.905 rs453184 chr6:167387404 A/C cg23791538 chr6:167370224 RNASET2 -0.38 -5.97 -0.31 6.08e-9 Crohn's disease; CRC cis rs3736485 0.873 rs12101920 chr15:51820909 T/C cg08986416 chr15:51914746 DMXL2 -0.48 -6.94 -0.36 2.14e-11 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs4665809 0.525 rs4665324 chr2:26447147 A/C cg08067268 chr2:26466485 HADHB;HADHA -0.66 -8.38 -0.42 1.54e-15 Gut microbiome composition (summer); CRC cis rs12134245 0.776 rs625525 chr1:91997593 C/T cg25838465 chr1:92012736 NA -0.73 -14.1 -0.61 1.17e-35 Breast cancer; CRC cis rs10791097 0.720 rs6590516 chr11:130733393 G/T cg12179176 chr11:130786555 SNX19 0.71 11.25 0.53 4.59e-25 Autism spectrum disorder or schizophrenia;Schizophrenia; CRC cis rs3785574 0.745 rs2854162 chr17:61975610 T/C cg25654072 chr17:61904446 PSMC5;FTSJ3 -0.43 -5.77 -0.3 1.8e-8 Height; CRC cis rs34172651 0.917 rs2059134 chr16:24816492 C/T cg04756594 chr16:24857601 SLC5A11 -0.24 -5.85 -0.31 1.21e-8 Intelligence (multi-trait analysis); CRC cis rs8072100 1.000 rs4375701 chr17:45712218 C/T cg08085267 chr17:45401833 C17orf57 -0.65 -10.66 -0.51 5.56e-23 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC trans rs2303319 0.504 rs12467613 chr2:162603216 G/T cg20024234 chr21:43431083 ZNF295 -0.66 -5.99 -0.31 5.57e-9 Cognitive function; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg25756398 chr11:93474621 C11orf54;TAF1D 0.4 6.24 0.33 1.38e-9 Liver disease severity in Alagille syndrome; CRC cis rs6582630 0.576 rs4403871 chr12:38292193 G/A cg26384229 chr12:38710491 ALG10B -0.52 -7.41 -0.38 1.11e-12 Drug-induced liver injury (flucloxacillin); CRC cis rs4819052 1.000 rs13053002 chr21:46677854 C/T cg02159808 chr21:46707872 POFUT2;LOC642852 0.66 8.18 0.41 6.32e-15 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs13108904 0.539 rs13141992 chr4:1340765 C/T cg15763984 chr4:1342303 KIAA1530 0.45 6.83 0.35 4.02e-11 Obesity-related traits; CRC cis rs9304742 0.962 rs1808106 chr19:53452944 T/G cg09915433 chr19:53449742 NA -0.67 -10.29 -0.49 1.02e-21 Psoriasis; CRC cis rs936229 0.813 rs3784790 chr15:75081745 G/C cg10253484 chr15:75165896 SCAMP2 -0.39 -5.64 -0.3 3.74e-8 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); CRC trans rs10802346 0.545 rs10802345 chr1:246372834 C/T cg22732515 chr19:44031385 ETHE1 0.61 9.1 0.45 9.18e-18 Fractional exhaled nitric oxide (childhood); CRC cis rs4332037 0.539 rs56305291 chr7:2048706 A/G cg02825527 chr7:2087843 MAD1L1 -0.51 -6.04 -0.32 4.14e-9 Bipolar disorder; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg06341202 chr17:78010343 CCDC40;TBC1D16 0.48 6.54 0.34 2.34e-10 Anxiety disorder; CRC cis rs7666738 0.830 rs11097609 chr4:99011707 C/T cg17366294 chr4:99064904 C4orf37 0.44 7.35 0.38 1.55e-12 Colonoscopy-negative controls vs population controls; CRC cis rs6893300 0.542 rs7736300 chr5:179196898 G/A cg14593053 chr5:179126677 CANX 0.49 7.82 0.4 7.35e-14 Resting heart rate; CRC cis rs9311676 0.632 rs6774577 chr3:58361716 A/G cg06643156 chr3:58380774 PXK 0.43 6.64 0.34 1.3100000000000001e-10 Systemic lupus erythematosus; CRC cis rs12594515 0.967 rs67854274 chr15:45990518 A/G cg19682013 chr15:45996608 NA 0.32 6.7 0.35 9.09e-11 Waist circumference;Weight; CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg05654483 chr10:122610929 WDR11 0.43 6.78 0.35 5.55e-11 Obesity-related traits; CRC cis rs10256972 0.567 rs2949185 chr7:1209013 A/G cg27094323 chr7:1216898 NA -0.37 -5.91 -0.31 8.47e-9 Longevity;Endometriosis; CRC cis rs10992471 0.729 rs2181585 chr9:95551830 G/A cg14631576 chr9:95140430 CENPP -0.33 -6.05 -0.32 3.94e-9 Visceral adipose tissue/subcutaneous adipose tissue ratio; CRC cis rs2153535 0.542 rs915354 chr6:8440357 T/C cg07606381 chr6:8435919 SLC35B3 0.67 10.68 0.51 4.61e-23 Motion sickness; CRC cis rs2303759 0.709 rs10422677 chr19:49824290 C/T cg22133161 chr19:49891603 CCDC155 0.5 6.52 0.34 2.69e-10 Multiple sclerosis; CRC cis rs12142240 0.738 rs17361749 chr1:46806480 C/T cg00530320 chr1:46809349 NSUN4 0.58 7.84 0.4 6.26e-14 Menopause (age at onset); CRC cis rs2933343 0.729 rs789231 chr3:128602847 A/G cg11901034 chr3:128598214 ACAD9 -0.55 -7.76 -0.39 1.06e-13 IgG glycosylation; CRC cis rs3820068 0.637 rs4646080 chr1:15826627 A/T cg27534772 chr1:16042836 PLEKHM2 0.41 6.95 0.36 1.99e-11 Systolic blood pressure; CRC cis rs40363 0.672 rs1617722 chr16:3520806 C/T cg22508957 chr16:3507546 NAT15 -0.63 -9.65 -0.47 1.42e-19 Tuberculosis; CRC cis rs3087591 0.922 rs2905799 chr17:29536901 G/A cg24425628 chr17:29625626 OMG;NF1 0.83 16.28 0.67 3.95e-44 Hip circumference; CRC cis rs3785574 0.962 rs2597632 chr17:61894739 A/T cg06601766 chr17:61851465 DDX42;CCDC47 0.6 8.45 0.42 9.3e-16 Height; CRC cis rs1003719 0.614 rs1053808 chr21:38525356 T/C cg10648535 chr21:38446584 PIGP;TTC3 -0.44 -6.18 -0.32 1.87e-9 Eye color traits; CRC cis rs10504229 0.683 rs59528137 chr8:58138565 C/T cg02290350 chr8:58132656 NA -0.61 -7.12 -0.37 6.7e-12 Developmental language disorder (linguistic errors); CRC cis rs4589502 0.841 rs75991095 chr15:67123224 C/G cg12317470 chr15:67143691 NA 0.73 5.75 0.3 2.08e-8 Lung cancer (smoking interaction); CRC cis rs2440129 0.632 rs2292353 chr17:6903537 C/T cg12262378 chr17:6899522 ALOX12 0.55 10.46 0.5 2.77e-22 Tonsillectomy; CRC cis rs875971 0.522 rs34973832 chr7:65396204 A/G cg00343986 chr7:65444356 GUSB 0.56 8.54 0.43 4.98e-16 Aortic root size; CRC cis rs6908034 0.607 rs75110577 chr6:19814523 C/T cg02682789 chr6:19804855 NA 0.81 6.48 0.34 3.35e-10 Endometriosis;Deep ovarian and/or rectovaginal disease with dense adhesions; CRC cis rs6951245 1.000 rs11767527 chr7:1097394 T/C cg21664854 chr7:1097933 C7orf50;GPR146 0.77 8.8 0.44 7.85e-17 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC trans rs11764590 0.715 rs56289396 chr7:2091415 G/A cg11693508 chr17:37793320 STARD3 0.6 6.99 0.36 1.58e-11 Neuroticism; CRC cis rs4713118 0.513 rs149945 chr6:28002853 T/C cg21251018 chr6:28226885 NKAPL 0.48 7.51 0.38 5.5e-13 Parkinson's disease; CRC cis rs12971120 0.891 rs4891558 chr18:72170359 A/G cg26446133 chr18:72167187 CNDP2 -0.72 -10.54 -0.5 1.39e-22 Refractive error; CRC trans rs587242 0.955 rs35251373 chr1:96970538 C/T cg10631902 chr5:14652156 NA 0.4 6.08 0.32 3.27e-9 Body mass index (joint analysis main effects and physical activity interaction);Body mass index in physically inactive individuals;Body mass index; CRC cis rs56104184 0.723 rs116909499 chr19:49407733 C/T cg21252483 chr19:49399788 TULP2 -0.42 -6.69 -0.35 9.49e-11 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; CRC cis rs9393777 0.513 rs9368448 chr6:26649355 T/C cg12292205 chr6:26970375 C6orf41 -0.61 -6.99 -0.36 1.52e-11 Intelligence (multi-trait analysis); CRC cis rs17155006 0.563 rs451416 chr7:107738531 A/G cg05962710 chr7:107745446 LAMB4 -0.43 -7.53 -0.38 4.79e-13 Pneumococcal bacteremia; CRC trans rs2303319 0.504 rs62189042 chr2:162602320 G/T cg27342122 chr8:133787442 PHF20L1 -0.72 -6.12 -0.32 2.68e-9 Cognitive function; CRC cis rs7927592 0.913 rs7115374 chr11:68300076 G/T cg01657329 chr11:68192670 LRP5 -0.46 -6.58 -0.34 1.89e-10 Total body bone mineral density; CRC cis rs4332037 0.722 rs28705934 chr7:1916116 T/A cg25834613 chr7:1915315 MAD1L1 -0.5 -7.85 -0.4 6.08e-14 Bipolar disorder; CRC cis rs6952808 0.723 rs11766575 chr7:2005747 T/C cg20295408 chr7:1910781 MAD1L1 -0.46 -6.29 -0.33 1.01e-9 Bipolar disorder and schizophrenia; CRC cis rs6912958 0.781 rs7742965 chr6:88278196 T/C cg08069147 chr6:88032118 GJB7;C6orf162 -0.57 -8.57 -0.43 4.19e-16 Monocyte percentage of white cells; CRC cis rs7945705 0.719 rs2012680 chr11:8996059 G/A cg00186954 chr11:8933980 ST5;C11orf17 -0.46 -7.78 -0.39 9.71e-14 Hemoglobin concentration; CRC cis rs4731207 0.596 rs10954050 chr7:124577901 G/T cg23710748 chr7:124431027 NA -0.39 -6.12 -0.32 2.67e-9 Cutaneous malignant melanoma; CRC cis rs2243480 1.000 rs160655 chr7:65533214 T/C cg25985355 chr7:65971099 NA -0.51 -6.04 -0.32 4.25e-9 Diabetic kidney disease; CRC cis rs8105895 0.935 rs10406119 chr19:22245009 C/A cg02657401 chr19:22469223 NA -0.34 -5.65 -0.3 3.56e-8 Body mass index (change over time); CRC cis rs947211 0.950 rs1775145 chr1:205756143 C/A cg26354017 chr1:205819088 PM20D1 0.44 6.1 0.32 2.99e-9 Parkinson's disease; CRC cis rs1448094 0.933 rs11117102 chr12:86312720 A/C cg18827107 chr12:86230957 RASSF9 -0.39 -6.41 -0.33 5.07e-10 Major depressive disorder; CRC trans rs10504229 1.000 rs59071610 chr8:58186301 A/C cg04077850 chr5:125800366 GRAMD3 0.37 6.11 0.32 2.76e-9 Developmental language disorder (linguistic errors); CRC cis rs7727544 0.647 rs72793280 chr5:131562900 C/T cg12564285 chr5:131593104 PDLIM4 0.41 7.37 0.38 1.35e-12 Blood metabolite levels; CRC cis rs924607 0.966 rs1621827 chr5:635074 A/G cg24163568 chr5:669837 TPPP 0.43 6.83 0.35 4.09e-11 Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia; CRC cis rs7809950 0.678 rs2237661 chr7:106863123 T/C cg23024343 chr7:107201750 COG5 -0.7 -9.42 -0.46 8.35e-19 Coronary artery disease; CRC cis rs9549367 0.713 rs9549682 chr13:113830181 C/T cg18105134 chr13:113819100 PROZ -0.85 -12.49 -0.57 1.49e-29 Platelet distribution width; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T ch.4.185006926F chr4:184769932 NA 0.41 6.04 0.32 4.1e-9 Intelligence (multi-trait analysis); CRC cis rs2462686 0.932 rs2471557 chr7:46000595 G/C cg15898840 chr7:45960834 IGFBP3 -0.39 -5.86 -0.31 1.11e-8 Major depressive disorder; CRC cis rs4660306 0.961 rs3748643 chr1:45965703 G/T cg03123370 chr1:45965343 CCDC163P;MMACHC -0.56 -7.96 -0.4 2.9e-14 Homocysteine levels; CRC cis rs12580194 0.593 rs61956291 chr12:55797964 G/C cg19537932 chr12:55886519 OR6C68 -0.72 -9.09 -0.45 9.43e-18 Cancer; CRC cis rs7772486 0.686 rs2072911 chr6:146056801 G/A cg13319975 chr6:146136371 FBXO30 0.43 6.49 0.34 3.12e-10 Lobe attachment (rater-scored or self-reported); CRC cis rs1784581 0.588 rs1784606 chr6:162405992 A/T cg17173639 chr6:162384350 PARK2 -0.54 -8.43 -0.42 1.07e-15 Itch intensity from mosquito bite; CRC cis rs6582630 0.555 rs10880625 chr12:38526612 A/C cg13010199 chr12:38710504 ALG10B 0.47 5.97 0.31 5.99e-9 Drug-induced liver injury (flucloxacillin); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg06435639 chr8:37756942 RAB11FIP1 0.46 6.43 0.33 4.59e-10 Response to antipsychotic treatment; CRC cis rs651907 0.557 rs35117343 chr3:101445126 A/G cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.59 7.94 0.4 3.21e-14 Colorectal cancer; CRC cis rs754466 0.580 rs10824575 chr10:79549047 A/G cg26805224 chr10:79626177 DLG5 -0.48 -7.22 -0.37 3.65e-12 Liver enzyme levels (gamma-glutamyl transferase); CRC trans rs11098499 0.955 rs1511018 chr4:120161580 G/T cg25214090 chr10:38739885 LOC399744 0.52 8.01 0.4 2e-14 Corneal astigmatism; CRC cis rs10791323 0.519 rs329663 chr11:133754543 A/G cg15485101 chr11:133734466 NA 0.45 8.47 0.42 8.05e-16 Childhood ear infection; CRC cis rs11098499 0.863 rs2170276 chr4:120485824 A/C cg09307838 chr4:120376055 NA 0.67 9.99 0.48 1.1e-20 Corneal astigmatism; CRC cis rs2692947 0.740 rs11695514 chr2:96548068 C/T cg23100626 chr2:96804247 ASTL 0.26 6.89 0.36 2.83e-11 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; CRC cis rs1552244 0.572 rs59074548 chr3:10164347 G/C cg18598329 chr3:10140678 FANCD2;C3orf24 -0.91 -10.81 -0.51 1.62e-23 Alzheimer's disease; CRC cis rs951366 0.668 rs823154 chr1:205762406 C/T cg14893161 chr1:205819251 PM20D1 0.94 16.35 0.67 2.16e-44 Menarche (age at onset); CRC cis rs7737355 1.000 rs27708 chr5:130743541 C/T cg06307176 chr5:131281290 NA -0.4 -6.05 -0.32 3.94e-9 Life satisfaction; CRC cis rs2635047 0.783 rs9948677 chr18:44790343 G/A cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.37 5.77 0.3 1.82e-8 Educational attainment; CRC cis rs6951245 0.507 rs11976805 chr7:1138716 C/T cg21664854 chr7:1097933 C7orf50;GPR146 0.54 7.26 0.37 2.81e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs754466 0.874 rs55910200 chr10:79665173 T/C cg17075019 chr10:79541650 NA -0.73 -9.99 -0.48 1.09e-20 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs6912958 0.702 rs2300909 chr6:88212100 G/A cg12350822 chr6:88032061 C6orf162;GJB7 -0.34 -6.48 -0.34 3.29e-10 Monocyte percentage of white cells; CRC cis rs6674176 0.561 rs4660263 chr1:44421433 A/C cg12908607 chr1:44402522 ARTN -0.59 -10.6 -0.5 8.55e-23 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Cognitive ability; CRC cis rs68170813 0.559 rs80017637 chr7:107050660 T/C cg02696742 chr7:106810147 HBP1 -0.57 -5.95 -0.31 6.9e-9 Coronary artery disease; CRC cis rs11229555 0.874 rs17567523 chr11:58354081 G/A cg15696309 chr11:58395628 NA -0.95 -12.73 -0.57 1.82e-30 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; CRC cis rs10782582 0.609 rs1630302 chr1:76412090 A/T cg10523679 chr1:76189770 ACADM -0.4 -5.75 -0.3 2.07e-8 Daytime sleep phenotypes; CRC cis rs1005277 0.522 rs289649 chr10:37975384 T/C cg25427524 chr10:38739819 LOC399744 -0.73 -12.4 -0.56 3.17e-29 Extrinsic epigenetic age acceleration; CRC cis rs9486719 0.901 rs760619 chr6:96857431 A/G cg18709589 chr6:96969512 KIAA0776 0.52 5.72 0.3 2.38e-8 Migraine;Coronary artery disease; CRC cis rs79349575 0.870 rs12941262 chr17:46967037 T/A cg22482690 chr17:47019901 SNF8 0.49 8.16 0.41 7.35e-15 Type 2 diabetes; CRC cis rs7762018 1.000 rs6941766 chr6:170131653 A/G cg19338460 chr6:170058176 WDR27 -0.67 -7.38 -0.38 1.27e-12 Thiazide-induced adverse metabolic effects in hypertensive patients; CRC cis rs3820068 0.603 rs3795763 chr1:15959977 C/T cg24675056 chr1:15929824 NA 0.5 6.81 0.35 4.53e-11 Systolic blood pressure; CRC cis rs965469 1.000 rs8123289 chr20:3253831 T/C cg25506879 chr20:3388711 C20orf194 -0.39 -5.63 -0.3 3.88e-8 IFN-related cytopenia; CRC cis rs9914988 0.943 rs7211502 chr17:27163295 C/A cg16670446 chr17:27188758 MIR451;MIR144 0.54 8.31 0.42 2.48e-15 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC trans rs7618501 1.000 rs2271961 chr3:49878113 C/T cg21665057 chr3:196295764 WDR53;FBXO45 -0.86 -16.38 -0.67 1.69e-44 Intelligence (multi-trait analysis); CRC cis rs9921222 0.500 rs8046256 chr16:393948 C/T cg00101154 chr16:420108 MRPL28 -0.87 -11.46 -0.53 8.01e-26 Bone mineral density (spine);Bone mineral density; CRC cis rs7927771 0.826 rs2293578 chr11:47437403 C/T cg18512352 chr11:47633146 NA -0.41 -8.05 -0.41 1.49e-14 Subjective well-being; CRC cis rs13108904 0.539 rs13141169 chr4:1340353 C/T cg00684032 chr4:1343700 KIAA1530 0.61 8.37 0.42 1.65e-15 Obesity-related traits; CRC cis rs7552404 0.727 rs6678348 chr1:76332463 C/T cg03433033 chr1:76189801 ACADM 0.67 8.69 0.43 1.78e-16 Blood metabolite levels;Acylcarnitine levels; CRC cis rs6502050 0.835 rs8073645 chr17:80110957 C/T cg22110888 chr17:80059540 CCDC57 0.4 6.44 0.33 4.17e-10 Life satisfaction; CRC cis rs2015599 0.549 rs6487799 chr12:29444020 A/G cg09582351 chr12:29534625 ERGIC2 -0.26 -5.71 -0.3 2.47e-8 Mean platelet volume;Platelet count; CRC cis rs17443541 0.507 rs1823488 chr2:200463830 G/A cg03741458 chr2:200468445 NA -0.36 -5.76 -0.3 1.91e-8 Intelligence (multi-trait analysis); CRC cis rs881375 0.715 rs7858209 chr9:123645760 G/A cg09419670 chr9:123605666 PSMD5;LOC253039 0.47 7.24 0.37 3.29e-12 Rheumatoid arthritis; CRC cis rs875971 0.638 rs801205 chr7:66022144 C/A cg00343986 chr7:65444356 GUSB -0.49 -7.42 -0.38 1e-12 Aortic root size; CRC cis rs66573146 0.572 rs66734745 chr4:6948765 T/C cg26116260 chr4:7069785 GRPEL1 -0.59 -5.68 -0.3 3.01e-8 Granulocyte percentage of myeloid white cells; CRC cis rs6540556 0.769 rs909710 chr1:209930694 A/G cg05527609 chr1:210001259 C1orf107 0.55 6.32 0.33 8.32e-10 Red blood cell count; CRC cis rs2836950 0.565 rs2836942 chr21:40591381 A/G cg11644478 chr21:40555479 PSMG1 -0.49 -7.31 -0.37 2.05e-12 Menarche (age at onset); CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg10776493 chr7:16684321 BZW2;ANKMY2 0.49 6.48 0.34 3.38e-10 Thyroid stimulating hormone; CRC cis rs35306767 0.903 rs12249634 chr10:872744 G/A cg26597838 chr10:835615 NA 0.97 11.68 0.54 1.3e-26 Eosinophil percentage of granulocytes; CRC cis rs10461617 0.617 rs6874733 chr5:56069600 A/G cg24531977 chr5:56204891 C5orf35 -0.46 -6.05 -0.32 3.92e-9 Type 2 diabetes; CRC cis rs2439831 0.850 rs7179388 chr15:44123945 C/G cg15269541 chr15:43626905 ADAL -0.51 -5.62 -0.3 4.11e-8 Lung cancer in ever smokers; CRC trans rs820077 0.609 rs9469955 chr6:35142235 T/A cg23173586 chr14:20945319 PNP -0.29 -6.03 -0.32 4.43e-9 Systemic lupus erythematosus; CRC cis rs4481887 1.000 rs7525344 chr1:248467565 C/T cg00666640 chr1:248458726 OR2T12 -0.55 -9.65 -0.47 1.43e-19 Common traits (Other); CRC cis rs2415984 0.579 rs1494097 chr14:46960552 T/C cg14871534 chr14:47121158 RPL10L 0.4 5.91 0.31 8.5e-9 Number of children ever born; CRC cis rs4363385 0.720 rs1611754 chr1:152956415 A/T cg25856811 chr1:152973957 SPRR3 -0.26 -7.22 -0.37 3.66e-12 Inflammatory skin disease; CRC cis rs7618501 0.633 rs9853222 chr3:50022926 T/C cg05623727 chr3:50126028 RBM5 0.46 7.55 0.38 4.29e-13 Intelligence (multi-trait analysis); CRC cis rs854572 0.870 rs757158 chr7:94955528 C/T cg07404485 chr7:94953653 PON1 -0.6 -9.84 -0.48 3.32e-20 Paraoxonase activity; CRC cis rs1976403 0.659 rs10799700 chr1:21820968 G/C cg02390115 chr1:21767211 NBPF3 0.55 8.34 0.42 2.13e-15 Liver enzyme levels (alkaline phosphatase); CRC cis rs13082711 0.522 rs640065 chr3:27363937 A/T cg02860705 chr3:27208620 NA 0.44 6.18 0.32 1.87e-9 Systolic blood pressure;Diastolic blood pressure;Blood pressure; CRC cis rs896854 1.000 rs7003387 chr8:95961979 C/G cg13393036 chr8:95962371 TP53INP1 -0.53 -8.91 -0.44 3.61e-17 Type 2 diabetes; CRC cis rs2976388 1.000 rs2920295 chr8:143764937 A/G cg20041105 chr8:143859282 LYNX1 -0.34 -5.86 -0.31 1.11e-8 Urinary tract infection frequency; CRC cis rs7737355 0.947 rs1468303 chr5:130804400 T/C cg06307176 chr5:131281290 NA -0.43 -6.36 -0.33 6.6e-10 Life satisfaction; CRC cis rs79349575 0.783 rs4794003 chr17:47029904 C/T cg22482690 chr17:47019901 SNF8 0.5 8.26 0.41 3.58e-15 Type 2 diabetes; CRC cis rs2730260 0.537 rs55683317 chr7:158878599 C/T cg02254261 chr7:158964346 NA -0.55 -6.28 -0.33 1.08e-9 Myopia (pathological); CRC cis rs72627123 0.867 rs73301485 chr14:74468643 T/C cg12022184 chr14:74485813 ENTPD5;C14orf45 0.71 5.92 0.31 8.3e-9 Morning vs. evening chronotype; CRC cis rs3733585 0.699 rs28613263 chr4:9964880 C/T cg11266682 chr4:10021025 SLC2A9 -0.47 -9.67 -0.47 1.28e-19 Cleft plate (environmental tobacco smoke interaction); CRC cis rs6500602 0.702 rs9929475 chr16:4540885 C/T cg08645402 chr16:4508243 NA -0.55 -9.48 -0.46 5.19e-19 Schizophrenia; CRC cis rs9435341 0.929 rs1762509 chr1:107592959 A/G cg14671364 chr1:107599128 PRMT6 -0.62 -8.27 -0.41 3.36e-15 Facial morphology (factor 21, depth of nasal alae); CRC trans rs561341 0.714 rs473535 chr17:30312365 A/G cg20587970 chr11:113659929 NA -1.42 -20.23 -0.74 1.03e-59 Hip circumference adjusted for BMI; CRC cis rs734999 0.505 rs10797438 chr1:2540262 C/T cg18854424 chr1:2615690 NA 0.49 9.9 0.48 2.21e-20 Ulcerative colitis; CRC cis rs311392 0.903 rs6993362 chr8:55089220 A/G cg20636351 chr8:55087400 NA -0.33 -5.99 -0.31 5.59e-9 Pelvic organ prolapse (moderate/severe); CRC cis rs6951245 0.938 rs117729148 chr7:1108531 G/A cg21664854 chr7:1097933 C7orf50;GPR146 0.78 8.89 0.44 4.21e-17 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC trans rs1814175 0.817 rs7929173 chr11:49944007 T/C cg11707556 chr5:10655725 ANKRD33B -0.44 -8.33 -0.42 2.24e-15 Height; CRC cis rs7692995 1.000 rs7694606 chr4:18028987 G/A cg08925142 chr4:18023851 LCORL -0.53 -5.86 -0.31 1.13e-8 Height; CRC cis rs4862750 0.957 rs6858853 chr4:187903412 A/C cg06074448 chr4:187884817 NA 0.6 11.07 0.52 1.99e-24 Lobe attachment (rater-scored or self-reported); CRC cis rs9549367 0.789 rs6577035 chr13:113879997 G/A cg18105134 chr13:113819100 PROZ -0.72 -10.88 -0.51 9.35e-24 Platelet distribution width; CRC cis rs7811142 0.830 rs28495773 chr7:99943583 A/T cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.14 15.1 0.64 1.72e-39 Platelet count; CRC cis rs7937682 0.883 rs510388 chr11:111451869 G/T cg09085632 chr11:111637200 PPP2R1B 0.88 16.48 0.67 6.71e-45 Primary sclerosing cholangitis; CRC cis rs7216064 1.000 rs4569324 chr17:65872750 C/T cg12091567 chr17:66097778 LOC651250 -0.67 -7.74 -0.39 1.24e-13 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CRC cis rs853679 0.517 rs4713144 chr6:28106790 C/G cg06470822 chr6:28175283 NA 1.0 13.33 0.59 1.06e-32 Depression; CRC cis rs2932538 0.922 rs12048528 chr1:113210534 A/C cg22162597 chr1:113214053 CAPZA1 -0.68 -9.67 -0.47 1.26e-19 Systolic blood pressure;Diastolic blood pressure;Hypertension;Blood pressure; CRC cis rs2116941 1.000 rs7250265 chr19:10339818 G/C cg01850179 chr19:10340795 S1PR2 -0.79 -11.33 -0.53 2.46e-25 Pulse pressure; CRC cis rs1799949 1.000 rs4793189 chr17:41190715 G/A cg19454999 chr17:41278357 BRCA1;NBR2 0.53 7.99 0.4 2.31e-14 Menopause (age at onset); CRC cis rs4692589 0.606 rs34752946 chr4:170951738 G/T cg19918862 chr4:170955249 NA 0.55 6.84 0.35 3.94e-11 Anxiety disorder; CRC cis rs11105298 1.000 rs11105298 chr12:89876143 C/T cg08166232 chr12:89918718 WDR51B;GALNT4 0.6 7.64 0.39 2.33e-13 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; CRC cis rs9322193 0.923 rs35830138 chr6:149989771 T/C cg00933542 chr6:150070202 PCMT1 0.3 6.17 0.32 2.05e-9 Lung cancer; CRC cis rs6951245 1.000 rs28399710 chr7:1070631 G/T cg03188948 chr7:1209495 NA 0.63 6.52 0.34 2.64e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs1865760 0.566 rs9467663 chr6:26021456 C/G cg16482183 chr6:26056742 HIST1H1C 0.52 7.6 0.39 3.2e-13 Height; CRC cis rs7945705 0.935 rs2653593 chr11:8877317 G/A cg14711859 chr11:8959438 ASCL3 0.46 7.66 0.39 2.12e-13 Hemoglobin concentration; CRC cis rs7249142 0.549 rs7260127 chr19:19280499 C/T cg26504305 chr19:19281019 LOC729991-MEF2B;MEF2B 0.43 8.61 0.43 2.99e-16 IgG glycosylation; CRC cis rs2075371 1.000 rs447266 chr7:133989543 A/G cg02659138 chr7:134003124 SLC35B4 0.4 7.09 0.36 8.11e-12 Mean platelet volume; CRC cis rs732505 1.000 rs4807790 chr19:5584614 A/G cg26242866 chr19:5711310 LONP1 0.54 5.67 0.3 3.18e-8 vWF and FVIII levels; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg23943013 chr5:79551904 SERINC5 0.48 8.12 0.41 9.5e-15 Liver disease severity in Alagille syndrome; CRC cis rs6563739 0.616 rs12017722 chr13:40224401 C/T cg00026919 chr13:40226031 NA 0.5 6.41 0.33 4.98e-10 Menarche (age at onset); CRC cis rs9486719 1.000 rs2472897 chr6:96870569 G/T cg06623918 chr6:96969491 KIAA0776 0.8 9.39 0.46 9.94e-19 Migraine;Coronary artery disease; CRC cis rs477692 1.000 rs531572 chr10:131427569 A/G cg05714579 chr10:131428358 MGMT -0.57 -8.51 -0.42 6.07e-16 Response to temozolomide; CRC cis rs6933660 0.800 rs9383900 chr6:151782816 A/C cg10883421 chr6:151773342 RMND1;C6orf211 0.76 13.61 0.6 9.34e-34 Menarche (age at onset); CRC cis rs832540 0.931 rs832399 chr5:56222358 A/T cg12311346 chr5:56204834 C5orf35 -0.53 -8.19 -0.41 5.85e-15 Coronary artery disease; CRC cis rs4789693 0.938 rs4789694 chr17:80428099 A/C cg04308225 chr17:80449738 NA -0.54 -7.41 -0.38 1.08e-12 Glucocorticoid-induced osteonecrosis; CRC cis rs2502731 0.539 rs3003610 chr9:130985525 G/A cg09976142 chr9:130955436 CIZ1 0.42 7.18 0.37 4.65e-12 Attention deficit hyperactivity disorder; CRC trans rs4332037 0.707 rs56070303 chr7:1891015 C/T cg11693508 chr17:37793320 STARD3 0.64 8.24 0.41 4.16e-15 Bipolar disorder; CRC cis rs4478858 0.735 rs10798842 chr1:31778648 A/G cg00250761 chr1:31883323 NA -0.38 -7.23 -0.37 3.44e-12 Alcohol dependence; CRC cis rs13082711 0.911 rs17682751 chr3:27497027 C/T cg02860705 chr3:27208620 NA -0.62 -8.63 -0.43 2.61e-16 Systolic blood pressure;Diastolic blood pressure;Blood pressure; CRC cis rs7572644 0.680 rs12465012 chr2:28028191 C/T cg27432699 chr2:27873401 GPN1 0.46 6.18 0.32 1.87e-9 Response to carboplatin and paclitaxel in ovarian cancer (Caspase 3/7 EC50); CRC cis rs8017423 0.647 rs10132599 chr14:90815342 C/T cg14092571 chr14:90743983 NA 0.39 5.89 0.31 9.54e-9 Mortality in heart failure; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg07121733 chr10:123734241 NSMCE4A 0.47 6.88 0.35 2.96e-11 Intelligence (multi-trait analysis); CRC cis rs941873 0.838 rs2233713 chr10:81107135 A/C cg08514558 chr10:81106712 PPIF 0.36 5.8 0.3 1.52e-8 Height; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg02664216 chr12:19592651 AEBP2 0.44 6.21 0.32 1.62e-9 Response to antipsychotic treatment; CRC cis rs8180040 1.000 rs807936 chr3:47322496 C/T cg10298567 chr3:47292165 KIF9 -0.4 -6.72 -0.35 7.9e-11 Colorectal cancer; CRC cis rs853679 0.517 rs9368556 chr6:28131153 T/C cg02631126 chr6:28058918 ZSCAN12L1 0.29 5.91 0.31 8.38e-9 Depression; CRC cis rs1059312 0.808 rs4760533 chr12:129297651 A/G cg23521905 chr12:129298690 SLC15A4;MGC16384 -0.38 -6.64 -0.34 1.28e-10 Systemic lupus erythematosus; CRC cis rs60871478 1.000 rs62432861 chr7:807649 G/A cg04727924 chr7:799746 HEATR2 -0.46 -6.9 -0.36 2.68e-11 Cerebrospinal P-tau181p levels; CRC cis rs9443645 0.527 rs9359362 chr6:79723756 T/C cg05283184 chr6:79620031 NA -0.45 -6.43 -0.33 4.49e-10 Intelligence (multi-trait analysis); CRC cis rs559928 0.606 rs56311067 chr11:63931607 C/T cg19465662 chr11:63993652 NUDT22;TRPT1 0.7 6.67 0.34 1.11e-10 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; CRC cis rs939317 0.635 rs865809 chr3:183997735 C/T cg09405238 chr3:183994500 ECE2 -0.49 -5.93 -0.31 7.66e-9 Menarche (age at onset); CRC cis rs17270561 0.609 rs3778272 chr6:25767661 G/A cg17691542 chr6:26056736 HIST1H1C 0.64 8.14 0.41 8.02e-15 Iron status biomarkers; CRC cis rs1865760 0.566 rs2032445 chr6:26044812 T/A cg18357526 chr6:26021779 HIST1H4A 0.42 5.95 0.31 7.03e-9 Height; CRC cis rs3731896 0.898 rs7596956 chr2:220152359 C/T cg00496455 chr2:220118770 TUBA4A;TUBA4B -0.46 -5.77 -0.3 1.85e-8 Educational attainment; CRC cis rs11664298 0.606 rs11081564 chr18:77551586 A/G cg24058013 chr18:77568902 NA -0.35 -5.63 -0.3 3.77e-8 Intelligence (multi-trait analysis); CRC trans rs2303319 0.504 rs62189041 chr2:162599506 T/C cg14875682 chr5:52083620 ITGA1;PELO -0.73 -6.16 -0.32 2.11e-9 Cognitive function; CRC cis rs7772486 0.754 rs6570718 chr6:146088443 T/G cg13319975 chr6:146136371 FBXO30 0.49 7.16 0.37 5.24e-12 Lobe attachment (rater-scored or self-reported); CRC cis rs9467603 0.925 rs28412066 chr6:25775570 T/A cg08501292 chr6:25962987 TRIM38 -0.99 -8.58 -0.43 3.89e-16 Intelligence (multi-trait analysis); CRC cis rs172166 0.694 rs203876 chr6:28046673 T/C cg10876282 chr6:28092338 ZSCAN16 0.48 6.53 0.34 2.51e-10 Cardiac Troponin-T levels; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg13227691 chr12:72233472 TBC1D15 0.38 6.04 0.32 4.25e-9 Liver disease severity in Alagille syndrome; CRC trans rs6550704 0.687 rs9865314 chr3:22634337 A/G cg06766450 chr1:16766999 NECAP2 -0.42 -6.15 -0.32 2.29e-9 Daytime sleep phenotypes; CRC cis rs853679 0.517 rs9393895 chr6:28127621 T/C cg02631126 chr6:28058918 ZSCAN12L1 0.3 5.99 0.31 5.45e-9 Depression; CRC cis rs9322193 0.962 rs1889473 chr6:150146621 C/G cg04369109 chr6:150039330 LATS1 -0.42 -5.69 -0.3 2.75e-8 Lung cancer; CRC cis rs1008375 0.932 rs9884565 chr4:17655096 A/G cg02297831 chr4:17616191 MED28 0.47 6.17 0.32 2.06e-9 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs1669338 0.588 rs7629889 chr3:3187643 C/T cg16797762 chr3:3221439 CRBN -0.59 -5.79 -0.3 1.65e-8 White matter integrity; CRC cis rs12983728 0.536 rs34380569 chr19:58648528 A/G cg21294424 chr19:58662284 ZNF329 0.52 6.6 0.34 1.63e-10 Cholesterol, total; CRC cis rs10504229 0.953 rs66676208 chr8:58173866 C/T cg02725872 chr8:58115012 NA -0.38 -6.43 -0.33 4.44e-10 Developmental language disorder (linguistic errors); CRC cis rs10504229 0.728 rs72650858 chr8:58152832 G/A cg02290350 chr8:58132656 NA -0.51 -6.57 -0.34 1.98e-10 Developmental language disorder (linguistic errors); CRC cis rs2274273 0.870 rs1952087 chr14:55683211 A/C cg23234261 chr14:55582407 NA -0.29 -5.67 -0.3 3.15e-8 Protein biomarker; CRC trans rs1200821 0.738 rs1926128 chr10:37654620 C/T cg25427524 chr10:38739819 LOC399744 0.42 6.25 0.33 1.25e-9 Hemostatic factors and hematological phenotypes; CRC cis rs2836950 0.545 rs8132143 chr21:40584258 A/T cg11644478 chr21:40555479 PSMG1 -0.5 -7.51 -0.38 5.49e-13 Menarche (age at onset); CRC cis rs4731207 0.698 rs4319000 chr7:124528055 C/T cg23710748 chr7:124431027 NA -0.38 -6.09 -0.32 3.13e-9 Cutaneous malignant melanoma; CRC cis rs6598955 0.671 rs17257176 chr1:26578233 G/A cg04990556 chr1:26633338 UBXN11 0.56 6.02 0.32 4.53e-9 Obesity-related traits; CRC cis rs7208859 0.673 rs9909497 chr17:29173228 C/A cg01831904 chr17:28903510 LRRC37B2 -0.55 -5.72 -0.3 2.33e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs6840360 1.000 rs6840678 chr4:152604331 C/G cg09659197 chr4:152720779 NA -0.5 -10.38 -0.5 5.01e-22 Intelligence (multi-trait analysis); CRC cis rs2032447 0.832 rs6922788 chr6:26052291 C/T cg26028573 chr6:26043587 HIST1H2BB 0.45 6.6 0.34 1.62e-10 Intelligence (multi-trait analysis); CRC cis rs4713118 0.784 rs9468219 chr6:27731755 C/A cg12273811 chr6:28175739 NA 0.5 6.72 0.35 8.08e-11 Parkinson's disease; CRC cis rs9611565 0.765 rs132907 chr22:41801268 A/C cg06634786 chr22:41940651 POLR3H 0.67 7.61 0.39 2.99e-13 Vitiligo; CRC cis rs4927850 0.521 rs4927679 chr3:195658360 C/T cg12923728 chr3:195709715 SDHAP1 0.44 6.65 0.34 1.19e-10 Pancreatic cancer; CRC cis rs7113874 0.589 rs9705253 chr11:8596483 A/T cg17679104 chr11:8615758 STK33 -0.36 -5.99 -0.31 5.52e-9 Body mass index in physically active individuals;Body mass index (joint analysis main effects and physical activity interaction); CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg04436714 chr1:90309218 LRRC8D 0.52 6.77 0.35 5.85e-11 Thyroid stimulating hormone; CRC cis rs904251 0.861 rs1757169 chr6:37487076 G/T cg25019722 chr6:37503610 NA -0.5 -9.29 -0.46 2.17e-18 Cognitive performance; CRC cis rs6667605 0.527 rs12046118 chr1:2540343 A/C cg18854424 chr1:2615690 NA 0.49 9.91 0.48 2.04e-20 Inflammatory bowel disease;Ulcerative colitis; CRC trans rs35094601 0.959 rs11690254 chr2:139225035 C/A cg25299176 chr17:1303341 YWHAE -0.47 -6.7 -0.35 9.16e-11 Schizophrenia; CRC cis rs2836950 0.501 rs2836983 chr21:40689336 G/A cg11644478 chr21:40555479 PSMG1 -0.44 -6.53 -0.34 2.56e-10 Menarche (age at onset); CRC cis rs12142240 0.660 rs112560929 chr1:46822297 A/G cg00530320 chr1:46809349 NSUN4 0.59 8.03 0.41 1.69e-14 Menopause (age at onset); CRC cis rs4727027 0.933 rs917122 chr7:148848257 T/C cg23583168 chr7:148888333 NA -0.92 -15.98 -0.66 6.18e-43 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC cis rs7312774 0.618 rs4964500 chr12:107320788 T/C cg16260113 chr12:107380972 MTERFD3 0.75 7.44 0.38 8.72e-13 Severe influenza A (H1N1) infection; CRC cis rs7246865 0.906 rs11666569 chr19:17214073 A/G cg19418318 chr19:17219073 MYO9B -0.48 -7.91 -0.4 3.89e-14 Reticulocyte fraction of red cells; CRC cis rs4803468 0.967 rs11083619 chr19:41913267 A/C cg09537434 chr19:41945824 ATP5SL -0.98 -18.86 -0.72 2.59e-54 Height; CRC cis rs7615952 0.641 rs12495947 chr3:125771698 C/T cg05084668 chr3:125655381 ALG1L -0.45 -6.47 -0.34 3.59e-10 Blood pressure (smoking interaction); CRC cis rs7208859 0.623 rs216446 chr17:28933718 T/G cg19761014 chr17:28927070 LRRC37B2 0.56 5.68 0.3 2.94e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs12681287 0.640 rs12549332 chr8:87353392 G/A cg27223183 chr8:87520930 FAM82B -0.52 -6.9 -0.36 2.72e-11 Caudate activity during reward; CRC cis rs67311347 1.000 rs2276870 chr3:40499182 C/T cg09455208 chr3:40491958 NA -0.44 -8.96 -0.44 2.44e-17 Renal cell carcinoma; CRC cis rs6502050 0.835 rs10163496 chr17:80110867 G/A cg13198984 chr17:80129470 CCDC57 0.46 8.16 0.41 6.94e-15 Life satisfaction; CRC cis rs6087990 0.806 rs4911259 chr20:31376282 A/C cg13636640 chr20:31349939 DNMT3B 0.76 15.4 0.65 1.08e-40 Ulcerative colitis; CRC cis rs847577 0.722 rs6951277 chr7:97711783 A/G cg24562669 chr7:97807699 LMTK2 0.76 16.53 0.67 4.35e-45 Breast cancer; CRC cis rs7901135 1.000 rs7901135 chr10:60586506 G/A cg23799393 chr10:60588674 BICC1 0.36 5.66 0.3 3.33e-8 Morning vs. evening chronotype; CRC cis rs7944584 0.545 rs7118178 chr11:47659135 G/A cg20307385 chr11:47447363 PSMC3 0.81 11.46 0.53 8.52e-26 Fasting blood glucose;Fasting blood glucose (BMI interaction); CRC cis rs12801636 0.846 rs1078457 chr11:65380124 C/T cg21033440 chr11:65409861 SIPA1 -0.52 -5.87 -0.31 1.04e-8 Coronary artery disease;HDL cholesterol;HDL cholesterol levels; CRC cis rs7940866 0.903 rs10791112 chr11:130870215 A/C cg12179176 chr11:130786555 SNX19 -0.57 -8.46 -0.42 8.9e-16 Schizophrenia; CRC cis rs35306767 0.761 rs11253538 chr10:1011166 C/T cg20503657 chr10:835505 NA 0.91 10.86 0.51 1.08e-23 Eosinophil percentage of granulocytes; CRC cis rs6460942 0.591 rs4721078 chr7:12334657 T/A cg20607287 chr7:12443886 VWDE -0.56 -6.15 -0.32 2.21e-9 Coronary artery disease; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg05284652 chr8:70746191 SLCO5A1 0.44 6.57 0.34 2e-10 Liver disease severity in Alagille syndrome; CRC cis rs9467773 0.565 rs4343916 chr6:26522675 A/T cg09904177 chr6:26538194 HMGN4 0.74 11.31 0.53 2.74e-25 Intelligence (multi-trait analysis); CRC cis rs853679 0.517 rs9393891 chr6:28079160 C/T cg12273811 chr6:28175739 NA 0.73 9.18 0.45 4.85e-18 Depression; CRC cis rs12282928 0.802 rs1105164 chr11:48285025 G/A cg20307385 chr11:47447363 PSMC3 0.48 5.98 0.31 5.86e-9 Migraine - clinic-based; CRC cis rs62229266 0.773 rs878606 chr21:37406692 G/A cg08632701 chr21:37451849 NA -0.44 -6.8 -0.35 4.92e-11 Mitral valve prolapse; CRC cis rs847577 0.609 rs6977321 chr7:97774859 A/G cg21770322 chr7:97807741 LMTK2 0.85 19.42 0.73 1.66e-56 Breast cancer; CRC cis rs916888 0.610 rs199438 chr17:44791643 G/A cg01570182 chr17:44337453 NA 0.76 9.44 0.46 7.24e-19 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs950169 1.000 rs34751999 chr15:84758419 T/C cg11189052 chr15:85197271 WDR73 0.6 8.83 0.44 6.13e-17 Schizophrenia; CRC cis rs7412746 0.658 rs3843843 chr1:150918084 C/T cg18016565 chr1:150552671 MCL1 0.42 5.96 0.31 6.51e-9 Melanoma; CRC trans rs79976124 0.800 rs12194767 chr6:66639599 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.69 8.31 0.42 2.48e-15 Type 2 diabetes; CRC cis rs2075371 1.000 rs2598291 chr7:133988313 C/G cg02659138 chr7:134003124 SLC35B4 0.36 6.11 0.32 2.75e-9 Mean platelet volume; CRC cis rs7412746 0.634 rs12096831 chr1:150864113 T/G cg15448220 chr1:150897856 SETDB1 0.56 8.27 0.41 3.47e-15 Melanoma; CRC cis rs6952808 0.582 rs10479762 chr7:2045351 T/C cg22963979 chr7:1858916 MAD1L1 0.45 6.95 0.36 1.91e-11 Bipolar disorder and schizophrenia; CRC trans rs8073060 0.559 rs10438814 chr17:34007065 A/G cg19694781 chr19:47549865 TMEM160 -1.07 -14.34 -0.62 1.5e-36 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; CRC cis rs1799949 1.000 rs35668327 chr17:41273095 G/A cg25072359 chr17:41440525 NA 0.46 6.9 0.36 2.74e-11 Menopause (age at onset); CRC cis rs9292777 0.649 rs348601 chr5:40320006 T/C cg09067459 chr5:40385259 NA -0.56 -9.56 -0.47 2.92e-19 Crohn's disease;Multiple sclerosis; CRC trans rs4942242 0.663 rs7319346 chr13:44218201 T/C cg27382691 chr15:76552771 ETFA;TYRO3P -0.46 -6.0 -0.31 5.27e-9 Response to tocilizumab in rheumatoid arthritis; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg22943782 chr6:3157966 TUBB2A 0.44 6.31 0.33 9.25e-10 Response to antipsychotic treatment; CRC cis rs2439831 0.702 rs3784275 chr15:44091386 G/A cg15269541 chr15:43626905 ADAL -0.59 -5.75 -0.3 2.04e-8 Lung cancer in ever smokers; CRC cis rs10751667 0.666 rs10902255 chr11:967268 T/C cg23136738 chr11:925521 AP2A2 -0.42 -7.09 -0.36 8.19e-12 Alzheimer's disease (late onset); CRC cis rs4713118 0.540 rs469227 chr6:27970705 A/C cg02683197 chr6:28174875 NA 0.65 9.03 0.45 1.48e-17 Parkinson's disease; CRC cis rs561341 1.000 rs8073186 chr17:30244956 T/C cg19193384 chr17:30244184 NA -0.49 -6.6 -0.34 1.66e-10 Hip circumference adjusted for BMI; CRC cis rs5753618 0.509 rs1034589 chr22:31579233 C/T cg07713946 chr22:31675144 LIMK2 -0.39 -5.72 -0.3 2.45e-8 Colorectal cancer; CRC cis rs8053891 0.615 rs3794695 chr16:72097827 C/T cg01557791 chr16:72042693 DHODH -0.56 -5.71 -0.3 2.56e-8 Coronary artery disease; CRC cis rs7197653 0.748 rs2279538 chr16:68397106 C/G cg05110241 chr16:68378359 PRMT7 -0.75 -7.75 -0.39 1.14e-13 Magnesium levels; CRC cis rs1799949 0.965 rs4793233 chr17:41435437 G/C cg01879757 chr17:41196368 BRCA1 -0.43 -6.61 -0.34 1.59e-10 Menopause (age at onset); CRC cis rs1577917 1.000 rs12216328 chr6:86703418 A/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.53 -6.64 -0.34 1.32e-10 Response to antipsychotic treatment; CRC trans rs453301 0.686 rs2409120 chr8:8882571 G/C cg16141378 chr3:129829833 LOC729375 0.43 6.42 0.33 4.68e-10 Joint mobility (Beighton score); CRC cis rs17155006 0.711 rs377007 chr7:107750446 T/A cg05962710 chr7:107745446 LAMB4 -0.41 -7.32 -0.37 1.97e-12 Pneumococcal bacteremia; CRC cis rs4237845 0.537 rs1599931 chr12:58258850 A/G cg02175503 chr12:58329896 NA 0.49 6.11 0.32 2.8e-9 Intelligence (multi-trait analysis); CRC cis rs72945132 0.882 rs7116191 chr11:70159781 G/A cg00319359 chr11:70116639 PPFIA1 0.68 7.51 0.38 5.61e-13 Coronary artery disease; CRC cis rs13082711 0.648 rs13085782 chr3:27404390 C/G cg02860705 chr3:27208620 NA 0.96 11.2 0.53 6.88e-25 Systolic blood pressure;Diastolic blood pressure;Blood pressure; CRC cis rs6921919 0.583 rs1054372 chr6:28336742 G/T cg21251018 chr6:28226885 NKAPL 0.4 6.09 0.32 3.12e-9 Autism spectrum disorder or schizophrenia; CRC cis rs6952808 0.689 rs12670737 chr7:2046830 C/T cg19624444 chr7:2048497 MAD1L1 0.32 5.8 0.3 1.57e-8 Bipolar disorder and schizophrenia; CRC cis rs597539 0.552 rs6591360 chr11:68718669 G/T cg04772025 chr11:68637568 NA 0.44 6.77 0.35 5.94e-11 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs58688157 0.705 rs12419720 chr11:598205 C/G cg07212818 chr11:638076 DRD4 -0.44 -5.78 -0.3 1.73e-8 Systemic lupus erythematosus; CRC trans rs10411161 0.702 rs11879436 chr19:52397815 T/A cg22319618 chr22:45562946 NUP50 -0.58 -6.01 -0.31 4.92e-9 Breast cancer; CRC cis rs10946940 0.896 rs12208078 chr6:27498581 G/A cg08798685 chr6:27730294 NA 0.38 5.72 0.3 2.38e-8 Systemic lupus erythematosus; CRC cis rs4237845 0.844 rs7306124 chr12:58303349 A/T cg02175503 chr12:58329896 NA 0.6 8.99 0.44 1.98e-17 Intelligence (multi-trait analysis); CRC cis rs2153535 0.541 rs9328471 chr6:8468842 T/C cg07606381 chr6:8435919 SLC35B3 0.67 10.7 0.51 4.01e-23 Motion sickness; CRC trans rs1005277 0.522 rs289650 chr10:37975505 G/T cg27523141 chr10:43048294 ZNF37B 0.41 6.04 0.32 4.06e-9 Extrinsic epigenetic age acceleration; CRC cis rs2635047 0.967 rs1119005 chr18:44725605 A/G cg19077165 chr18:44547161 KATNAL2 -0.44 -6.97 -0.36 1.72e-11 Educational attainment; CRC cis rs1862618 0.853 rs33325 chr5:56142547 G/C cg03609598 chr5:56110824 MAP3K1 -0.83 -10.27 -0.49 1.2e-21 Initial pursuit acceleration; CRC cis rs11122272 0.735 rs2790893 chr1:231508976 T/G cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.54 -8.11 -0.41 1.04e-14 Hemoglobin concentration; CRC cis rs34311866 0.748 rs10029038 chr4:899352 T/C cg07828340 chr4:882639 GAK 1.1 10.99 0.52 3.93e-24 Parkinson's disease; CRC cis rs9768139 0.733 rs12698209 chr7:158117595 A/G cg24154853 chr7:158122151 PTPRN2 -0.62 -10.55 -0.5 1.3e-22 Calcium levels; CRC cis rs7618915 0.547 rs7642198 chr3:52677960 T/C cg05573699 chr3:52720067 GNL3;PBRM1 -0.47 -6.68 -0.35 1.02e-10 Bipolar disorder; CRC cis rs1865760 0.929 rs1816546 chr6:25938252 C/T cg16482183 chr6:26056742 HIST1H1C 0.53 7.4 0.38 1.14e-12 Height; CRC trans rs208515 0.525 rs12214310 chr6:66666308 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.93 11.75 0.54 7.56e-27 Exhaled nitric oxide levels; CRC cis rs10924970 1.000 rs12095653 chr1:235327138 T/C cg26050004 chr1:235667680 B3GALNT2 0.39 5.74 0.3 2.12e-8 Asthma; CRC cis rs9399135 0.967 rs12661423 chr6:135349570 C/T cg24558204 chr6:135376177 HBS1L 0.51 8.22 0.41 4.68e-15 Red blood cell count; CRC cis rs600806 0.888 rs11102971 chr1:109872370 C/T cg23032129 chr1:109941072 SORT1 -0.28 -6.04 -0.32 4.16e-9 Intelligence (multi-trait analysis); CRC cis rs898097 0.510 rs10445242 chr17:80891666 G/T cg10494973 chr17:80897199 TBCD -0.37 -5.85 -0.31 1.16e-8 Breast cancer; CRC cis rs7618501 0.633 rs2252833 chr3:50004209 C/T cg24110177 chr3:50126178 RBM5 -0.51 -7.87 -0.4 5.01e-14 Intelligence (multi-trait analysis); CRC cis rs3761218 1.000 rs3761219 chr20:3776368 T/C cg25011176 chr20:3776985 CDC25B -0.43 -5.77 -0.3 1.86e-8 Bipolar disorder; CRC cis rs9916302 0.610 rs11078902 chr17:37631883 C/G cg03013999 chr17:37608204 MED1 0.43 6.6 0.34 1.68e-10 Glomerular filtration rate (creatinine); CRC cis rs896854 0.967 rs2879813 chr8:95960947 A/G cg16049864 chr8:95962084 TP53INP1 -0.67 -12.36 -0.56 4.45e-29 Type 2 diabetes; CRC cis rs13118159 0.934 rs2878608 chr4:1354286 C/G cg16405210 chr4:1374714 KIAA1530 -0.41 -5.73 -0.3 2.26e-8 Longevity; CRC cis rs7412746 0.634 rs72704658 chr1:150833010 T/C cg10589385 chr1:150898437 SETDB1 0.33 6.76 0.35 6.15e-11 Melanoma; CRC cis rs2243480 1.000 rs73142166 chr7:65375832 A/G cg25985355 chr7:65971099 NA -0.49 -5.66 -0.3 3.29e-8 Diabetic kidney disease; CRC cis rs6912958 0.754 rs4707374 chr6:88255438 T/C cg12350822 chr6:88032061 C6orf162;GJB7 -0.33 -6.34 -0.33 7.58e-10 Monocyte percentage of white cells; CRC cis rs68170813 0.559 rs4730231 chr7:106942039 G/C cg02696742 chr7:106810147 HBP1 -0.57 -6.26 -0.33 1.18e-9 Coronary artery disease; CRC cis rs7618915 0.547 rs34610878 chr3:52759169 G/C cg15147215 chr3:52552868 STAB1 -0.61 -10.07 -0.49 5.69e-21 Bipolar disorder; CRC trans rs10411161 0.702 rs10420224 chr19:52398955 A/G cg22319618 chr22:45562946 NUP50 -0.58 -6.01 -0.31 4.92e-9 Breast cancer; CRC cis rs7662987 0.517 rs1154406 chr4:100008494 T/C cg13256891 chr4:100009986 ADH5 0.62 8.16 0.41 7.34e-15 Smoking initiation; CRC cis rs7927771 0.894 rs12798346 chr11:47583121 C/T cg18512352 chr11:47633146 NA -0.48 -9.61 -0.47 1.97e-19 Subjective well-being; CRC cis rs2153535 0.580 rs9379210 chr6:8461928 C/G cg21535247 chr6:8435926 SLC35B3 0.5 7.56 0.38 4.13e-13 Motion sickness; CRC cis rs4727027 0.901 rs4727019 chr7:148822266 A/G cg23583168 chr7:148888333 NA -0.84 -13.92 -0.61 6.1e-35 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC cis rs561341 0.714 rs55925849 chr17:30253085 C/T cg23018236 chr17:30244563 NA -0.67 -7.93 -0.4 3.48e-14 Hip circumference adjusted for BMI; CRC cis rs9287719 0.649 rs12618726 chr2:10728375 C/G cg00105475 chr2:10696890 NA 0.44 7.0 0.36 1.43e-11 Prostate cancer; CRC cis rs1113500 0.862 rs2336128 chr1:108640739 G/T cg06207961 chr1:108661230 NA 0.39 5.68 0.3 3.03e-8 Growth-regulated protein alpha levels; CRC cis rs4819052 0.851 rs13052312 chr21:46662359 T/C cg19498844 chr21:46707878 POFUT2;LOC642852 0.77 11.02 0.52 3.04e-24 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC trans rs6601327 0.518 rs13264850 chr8:9575331 A/T cg06636001 chr8:8085503 FLJ10661 -0.51 -7.41 -0.38 1.07e-12 Multiple myeloma (hyperdiploidy); CRC cis rs7107174 1.000 rs57738705 chr11:77994489 A/G cg02023728 chr11:77925099 USP35 0.53 8.07 0.41 1.36e-14 Testicular germ cell tumor; CRC cis rs514406 0.505 rs431427 chr1:53179094 C/A cg08859206 chr1:53392774 SCP2 -0.4 -6.09 -0.32 3.1e-9 Monocyte count; CRC cis rs861020 0.606 rs657844 chr1:210006873 T/G cg05527609 chr1:210001259 C1orf107 0.77 10.7 0.51 4.09e-23 Orofacial clefts; CRC cis rs7945705 0.869 rs2742471 chr11:9003953 C/T cg00186954 chr11:8933980 ST5;C11orf17 -0.4 -6.5 -0.34 2.93e-10 Hemoglobin concentration; CRC cis rs950169 0.922 rs6603022 chr15:84830170 T/C cg17507749 chr15:85114479 UBE2QP1 -0.77 -11.41 -0.53 1.28e-25 Schizophrenia; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg02740969 chr7:139477893 TBXAS1;HIPK2 0.4 6.31 0.33 9.17e-10 Liver disease severity in Alagille syndrome; CRC cis rs10751667 0.600 rs6597948 chr11:1005308 C/T cg23136738 chr11:925521 AP2A2 -0.4 -6.19 -0.32 1.77e-9 Alzheimer's disease (late onset); CRC cis rs9443189 0.570 rs276687 chr6:76429995 G/T cg01950844 chr6:76311363 SENP6 -0.71 -8.93 -0.44 3.03e-17 Prostate cancer; CRC cis rs12541335 0.639 rs35068739 chr8:22201719 T/C cg02463440 chr8:22132932 PIWIL2 0.51 8.77 0.44 9.57e-17 Hypertriglyceridemia; CRC trans rs3733585 0.654 rs4447863 chr4:9938969 T/C cg26043149 chr18:55253948 FECH -0.52 -7.78 -0.39 9.21e-14 Cleft plate (environmental tobacco smoke interaction); CRC cis rs1904096 0.506 rs28701470 chr4:95167088 A/C cg11021082 chr4:95130006 SMARCAD1 -0.58 -9.07 -0.45 1.11e-17 Type 2 diabetes; CRC trans rs9858542 0.953 rs1987628 chr3:49399259 G/A cg21659725 chr3:3221576 CRBN -0.63 -8.62 -0.43 2.85e-16 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs2836633 0.931 rs2836635 chr21:40069850 A/G cg12884169 chr21:40033163 ERG 0.35 7.34 0.37 1.72e-12 Coronary artery disease; CRC cis rs6502050 0.835 rs4789675 chr17:80123144 G/A cg22110888 chr17:80059540 CCDC57 0.4 6.38 0.33 5.96e-10 Life satisfaction; CRC cis rs7618501 0.633 rs11130228 chr3:50003246 C/T cg24110177 chr3:50126178 RBM5 -0.5 -7.88 -0.4 4.98e-14 Intelligence (multi-trait analysis); CRC cis rs9443645 0.527 rs9343861 chr6:79744868 C/A cg05283184 chr6:79620031 NA -0.46 -6.61 -0.34 1.56e-10 Intelligence (multi-trait analysis); CRC trans rs1941687 0.702 rs1493924 chr18:31314721 T/C cg27147174 chr7:100797783 AP1S1 -0.39 -6.52 -0.34 2.65e-10 Subjective well-being (multi-trait analysis);Subjective well-being; CRC trans rs1814175 0.791 rs1722011 chr11:49899340 G/C cg03929089 chr4:120376271 NA -0.98 -19.25 -0.73 7.43e-56 Height; CRC cis rs11997175 0.545 rs5005657 chr8:33668913 C/G cg04338863 chr8:33670619 NA 0.41 6.74 0.35 7e-11 Body mass index; CRC trans rs12940923 1.000 rs35433894 chr17:56376042 A/G cg16900910 chr15:72789182 ARIH1 0.53 6.04 0.32 4.19e-9 Circulating myeloperoxidase levels (plasma); CRC trans rs2303319 0.504 rs58622044 chr2:162596287 A/G cg03757145 chr4:76555832 CDKL2 -0.65 -6.0 -0.31 5.07e-9 Cognitive function; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg00722097 chr6:111195976 AMD1 0.41 6.27 0.33 1.13e-9 Liver disease severity in Alagille syndrome; CRC cis rs1953600 0.870 rs12770550 chr10:81953451 G/T cg04850286 chr10:81895943 PLAC9 0.37 6.56 0.34 2.12e-10 Sarcoidosis; CRC cis rs35306767 0.714 rs12762955 chr10:1078782 A/C cg20503657 chr10:835505 NA 0.66 9.12 0.45 7.64e-18 Eosinophil percentage of granulocytes; CRC cis rs2734839 0.964 rs7131440 chr11:113299910 A/G cg14159747 chr11:113255604 NA -0.46 -8.1 -0.41 1.11e-14 Information processing speed; CRC cis rs17592366 0.540 rs7145614 chr14:35290846 C/T cg09327582 chr14:35236912 BAZ1A -0.48 -6.93 -0.36 2.22e-11 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells; CRC cis rs117623576 0.941 rs7912584 chr10:32416623 C/T cg03047570 chr10:32398778 NA -0.85 -9.07 -0.45 1.11e-17 Anti-saccade response; CRC cis rs11190604 1.000 rs1417823 chr10:102227886 C/T cg07080220 chr10:102295463 HIF1AN -0.46 -5.78 -0.3 1.69e-8 Palmitoleic acid (16:1n-7) levels; CRC cis rs2933343 1.000 rs6785869 chr3:128643144 G/A cg11901034 chr3:128598214 ACAD9 -0.52 -6.3 -0.33 9.3e-10 IgG glycosylation; CRC cis rs10883723 0.810 rs2296586 chr10:104245575 C/T cg04362960 chr10:104952993 NT5C2 -0.42 -5.97 -0.31 6.26e-9 Allergic disease (asthma, hay fever or eczema); CRC cis rs6502050 0.835 rs8065981 chr17:80091393 G/T cg13198984 chr17:80129470 CCDC57 0.47 8.43 0.42 1.09e-15 Life satisfaction; CRC cis rs1949733 1.000 rs1357481 chr4:8496221 A/T cg11789530 chr4:8429930 ACOX3 0.81 12.26 0.56 1.05e-28 Response to antineoplastic agents; CRC cis rs7107174 1.000 rs7112234 chr11:78102470 G/A cg02023728 chr11:77925099 USP35 0.46 7.76 0.39 1.08e-13 Testicular germ cell tumor; CRC cis rs9322817 0.691 rs1455935 chr6:105230312 C/G cg02098413 chr6:105308735 HACE1 -0.44 -8.55 -0.43 4.67e-16 Thyroid stimulating hormone; CRC cis rs1799949 1.000 rs11658754 chr17:41292739 G/A cg25072359 chr17:41440525 NA 0.46 6.97 0.36 1.79e-11 Menopause (age at onset); CRC cis rs9911578 0.933 rs2531726 chr17:56522533 C/T cg12560992 chr17:57184187 TRIM37 -0.87 -15.14 -0.64 1.12e-39 Intelligence (multi-trait analysis); CRC cis rs2252790 0.548 rs114094955 chr6:116521164 G/T cg18764771 chr6:116381957 FRK 0.25 5.77 0.3 1.81e-8 Fast beta electroencephalogram; CRC cis rs10504229 0.728 rs17216187 chr8:58158778 G/T cg24829409 chr8:58192753 C8orf71 -0.6 -8.07 -0.41 1.29e-14 Developmental language disorder (linguistic errors); CRC cis rs9733 0.596 rs34600506 chr1:150687808 C/G cg17724175 chr1:150552817 MCL1 0.57 9.12 0.45 7.76e-18 Tonsillectomy; CRC cis rs9462027 0.628 rs9462023 chr6:34769410 T/G cg07306190 chr6:34760872 UHRF1BP1 -0.34 -6.07 -0.32 3.47e-9 Systemic lupus erythematosus; CRC cis rs9326248 0.559 rs573549 chr11:116736679 A/G cg20608306 chr11:116969690 SIK3 0.34 6.97 0.36 1.75e-11 Blood protein levels; CRC cis rs6582630 0.555 rs10880613 chr12:38509553 C/T cg13010199 chr12:38710504 ALG10B 0.46 5.88 0.31 9.81e-9 Drug-induced liver injury (flucloxacillin); CRC cis rs3785574 0.962 rs2597632 chr17:61894739 A/T cg23090583 chr17:61904693 PSMC5;FTSJ3 0.65 9.26 0.45 2.71e-18 Height; CRC cis rs2717559 0.683 rs2717611 chr8:143879927 C/T cg04969067 chr8:143858791 LYNX1 -0.55 -9.64 -0.47 1.53e-19 Urinary tract infection frequency; CRC cis rs875971 0.793 rs460678 chr7:65527200 C/G cg12463550 chr7:65579703 CRCP 0.46 6.48 0.34 3.34e-10 Aortic root size; CRC cis rs2179367 0.881 rs2744432 chr6:149743871 A/C cg07828024 chr6:149772892 ZC3H12D 0.38 6.02 0.32 4.56e-9 Dupuytren's disease; CRC cis rs1865760 0.566 rs2032449 chr6:26026599 G/C cg18357526 chr6:26021779 HIST1H4A 0.41 5.74 0.3 2.12e-8 Height; CRC cis rs6723226 0.572 rs176411 chr2:32643528 A/G cg02381751 chr2:32503542 YIPF4 0.47 6.74 0.35 7.31e-11 Intelligence (multi-trait analysis); CRC cis rs1129187 0.755 rs7760250 chr6:42929839 G/A cg05552183 chr6:42928497 GNMT 0.51 7.93 0.4 3.43e-14 Alzheimer's disease in APOE e4+ carriers; CRC cis rs344364 0.511 rs911392 chr16:1947259 A/G cg03013636 chr16:1946785 NA 0.56 6.79 0.35 5.16e-11 Glomerular filtration rate in chronic kidney disease; CRC trans rs12639288 0.962 rs12638639 chr3:167660757 C/T cg19660720 chr22:25960296 ADRBK2 -0.42 -5.97 -0.31 6.16e-9 Hirschsprung disease; CRC cis rs2252521 0.553 rs1603907 chr7:29096263 A/G cg11728747 chr7:29037910 CPVL -0.49 -6.92 -0.36 2.3e-11 Cognitive performance; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg08547432 chr19:50143419 RRAS 0.5 6.92 0.36 2.34e-11 Response to antipsychotic treatment; CRC cis rs910316 0.934 rs8016330 chr14:75657507 G/T cg03030879 chr14:75389066 RPS6KL1 0.43 6.51 0.34 2.78e-10 Height; CRC cis rs4555082 0.830 rs2816614 chr14:105727359 C/T cg06808227 chr14:105710500 BRF1 -0.62 -8.83 -0.44 6.31e-17 Mean platelet volume;Platelet distribution width; CRC cis rs4481887 0.962 rs10749653 chr1:248481384 C/G cg00666640 chr1:248458726 OR2T12 0.55 9.53 0.47 3.53e-19 Common traits (Other); CRC cis rs3741404 0.620 rs12787945 chr11:63977546 G/A cg19465662 chr11:63993652 NUDT22;TRPT1 0.75 12.09 0.55 4.33e-28 Platelet count; CRC cis rs1799949 1.000 rs2175957 chr17:41286822 T/G cg25072359 chr17:41440525 NA 0.46 6.9 0.36 2.64e-11 Menopause (age at onset); CRC cis rs9311474 0.629 rs11709284 chr3:52559705 G/A cg13284614 chr3:52569169 NT5DC2;LOC440957 0.36 5.91 0.31 8.32e-9 Electroencephalogram traits; CRC cis rs1799949 0.965 rs7212284 chr17:41205941 A/G cg23758822 chr17:41437982 NA 0.84 15.61 0.65 1.72e-41 Menopause (age at onset); CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg13244260 chr10:112632027 LOC282997;PDCD4 0.5 6.44 0.33 4.14e-10 Thyroid stimulating hormone; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg18045461 chr22:29601862 EMID1 0.35 6.61 0.34 1.57e-10 Liver disease severity in Alagille syndrome; CRC cis rs2760061 0.583 rs708124 chr1:228220771 A/T cg01200585 chr1:228362443 C1orf69 0.49 6.73 0.35 7.77e-11 Diastolic blood pressure; CRC cis rs7493 0.950 rs17879277 chr7:95030632 A/C cg21856205 chr7:94953877 PON1 -0.5 -6.46 -0.34 3.73e-10 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs6500395 0.962 rs13331902 chr16:48644989 A/G cg04672837 chr16:48644449 N4BP1 0.42 5.83 0.31 1.31e-8 Response to tocilizumab in rheumatoid arthritis; CRC cis rs1577917 0.771 rs2842608 chr6:86295858 C/A cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.65 -8.59 -0.43 3.67e-16 Response to antipsychotic treatment; CRC cis rs559928 0.556 rs734762 chr11:63912189 G/C cg19465662 chr11:63993652 NUDT22;TRPT1 0.7 6.72 0.35 7.98e-11 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; CRC cis rs863345 0.625 rs7534112 chr1:158532065 G/A cg12129480 chr1:158549410 OR10X1 -0.35 -7.29 -0.37 2.38e-12 Pneumococcal bacteremia; CRC cis rs477895 0.713 rs882146 chr11:63976699 G/A cg04317338 chr11:64019027 PLCB3 0.63 7.58 0.39 3.5e-13 Mean platelet volume; CRC cis rs972578 1.000 rs5759059 chr22:43358492 G/A cg01576275 chr22:43409880 NA -0.45 -7.25 -0.37 3.08e-12 Mean platelet volume; CRC trans rs2235573 0.551 rs139895 chr22:38397034 A/G cg19894588 chr14:64061835 NA -0.44 -6.27 -0.33 1.13e-9 Glioblastoma;Glioma; CRC cis rs8060686 0.920 rs73591968 chr16:67803063 G/A cg07125278 chr16:67683757 RLTPR -0.63 -6.85 -0.35 3.56e-11 HDL cholesterol;Metabolic syndrome; CRC cis rs6963495 0.818 rs73192113 chr7:105169603 C/T cg13798780 chr7:105162888 PUS7 0.68 8.04 0.41 1.59e-14 Bipolar disorder (body mass index interaction); CRC cis rs644799 0.930 rs2186782 chr11:95649543 G/A cg25478527 chr11:95522999 CEP57;FAM76B 0.51 7.39 0.38 1.19e-12 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs231513 0.954 rs231497 chr17:41975947 A/G cg26893861 chr17:41843967 DUSP3 -0.62 -6.28 -0.33 1.04e-9 Cognitive function; CRC cis rs1451375 1.000 rs10250513 chr7:50621488 T/G cg14593290 chr7:50529359 DDC 0.55 7.7 0.39 1.65e-13 Malaria; CRC cis rs6951245 1.000 rs113575110 chr7:1084394 G/A cg20603222 chr7:1096387 C7orf50;GPR146 -0.69 -8.02 -0.4 1.87e-14 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs9818758 0.545 rs55921200 chr3:49189316 T/C cg01304814 chr3:48885189 PRKAR2A 0.87 6.31 0.33 8.86e-10 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; CRC cis rs2195987 0.668 rs4533408 chr19:24153804 A/G cg00460763 chr19:23944615 RPSAP58 0.55 5.98 0.31 5.71e-9 Testicular germ cell tumor; CRC cis rs2976388 0.566 rs2585141 chr8:143806343 G/A cg12516270 chr8:143859308 LYNX1 -0.42 -7.01 -0.36 1.34e-11 Urinary tract infection frequency; CRC cis rs1862618 0.802 rs2591949 chr5:56132627 T/C cg22800045 chr5:56110881 MAP3K1 0.58 6.44 0.33 4.15e-10 Initial pursuit acceleration; CRC cis rs1552244 0.554 rs6800204 chr3:9995404 A/G cg00166722 chr3:10149974 C3orf24 0.42 6.3 0.33 9.75e-10 Alzheimer's disease; CRC cis rs4819052 0.851 rs13047598 chr21:46660777 G/T cg02159808 chr21:46707872 POFUT2;LOC642852 0.49 6.41 0.33 5.19e-10 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs1218582 0.772 rs11264282 chr1:154867370 G/A cg24250549 chr1:154909240 PMVK 0.63 10.66 0.51 5.61e-23 Prostate cancer; CRC cis rs9916302 0.706 rs57933226 chr17:37412829 C/T cg00129232 chr17:37814104 STARD3 -0.56 -7.07 -0.36 9.33e-12 Glomerular filtration rate (creatinine); CRC cis rs116095464 0.558 rs9312956 chr5:201812 T/C cg22857025 chr5:266934 NA -1.14 -11.99 -0.55 1.03e-27 Breast cancer; CRC trans rs4813802 0.724 rs2876052 chr20:6711572 C/T cg12026095 chr19:49468461 FTL -0.49 -6.1 -0.32 2.99e-9 Colorectal cancer; CRC cis rs17345786 1.000 rs7641261 chr3:101279006 C/T cg12386194 chr3:101231763 SENP7 0.52 6.7 0.35 9.12e-11 Colonoscopy-negative controls vs population controls; CRC cis rs6964587 0.610 rs6942852 chr7:91437883 A/C cg17063962 chr7:91808500 NA 0.55 8.49 0.42 7.44e-16 Breast cancer; CRC cis rs1046896 0.514 rs67735447 chr17:80823042 G/T cg16060761 chr17:80687452 NA -0.43 -5.74 -0.3 2.17e-8 Glycated hemoglobin levels; CRC trans rs1005277 0.579 rs2474588 chr10:38420870 A/G cg27523141 chr10:43048294 ZNF37B 0.48 6.99 0.36 1.56e-11 Extrinsic epigenetic age acceleration; CRC cis rs6502050 0.799 rs12603050 chr17:80104631 A/G cg13198984 chr17:80129470 CCDC57 0.46 8.16 0.41 6.94e-15 Life satisfaction; CRC cis rs10106298 0.846 rs2436940 chr8:103678521 A/C cg10187029 chr8:103597600 NA 0.42 5.9 0.31 8.81e-9 Schizophrenia; CRC cis rs2204008 0.715 rs11495369 chr12:38238673 T/C cg26384229 chr12:38710491 ALG10B 0.68 9.09 0.45 9.67e-18 Bladder cancer; CRC cis rs10504229 0.953 rs115634610 chr8:58190533 G/A cg01721255 chr8:58191610 C8orf71 0.49 6.14 0.32 2.4e-9 Developmental language disorder (linguistic errors); CRC cis rs9322193 0.923 rs9688938 chr6:150110077 G/A cg05861140 chr6:150128134 PCMT1 -0.43 -7.05 -0.36 1.03e-11 Lung cancer; CRC trans rs6951245 1.000 rs80212261 chr7:1114012 C/T cg13565492 chr6:43139072 SRF -0.73 -7.52 -0.38 5.23e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs7072216 0.763 rs7923729 chr10:100169465 C/T cg26618903 chr10:100175079 PYROXD2 -0.55 -9.16 -0.45 5.81e-18 Metabolite levels; CRC cis rs9311474 0.508 rs3796353 chr3:52593230 C/T cg18099408 chr3:52552593 STAB1 -0.48 -8.31 -0.42 2.48e-15 Electroencephalogram traits; CRC cis rs35883536 0.967 rs1055044 chr1:101171354 A/G cg14515779 chr1:101123966 NA -0.35 -6.36 -0.33 6.74e-10 Monocyte count; CRC cis rs10504229 0.683 rs72649188 chr8:58108829 A/G cg22535103 chr8:58192502 C8orf71 -0.68 -8.76 -0.43 1.08e-16 Developmental language disorder (linguistic errors); CRC cis rs8072100 0.777 rs9914653 chr17:45537395 T/C cg25173405 chr17:45401733 C17orf57 -0.48 -7.6 -0.39 3.04e-13 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs6860806 0.507 rs273917 chr5:131659618 A/G cg27615366 chr5:131592974 PDLIM4 0.34 5.96 0.31 6.55e-9 Breast cancer; CRC cis rs9715521 0.935 rs56025348 chr4:59836741 T/G cg11281224 chr4:60001000 NA -0.38 -5.65 -0.3 3.53e-8 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC trans rs12702919 0.615 rs4427078 chr7:9556688 C/T cg15597424 chr4:24472487 NA -0.38 -6.01 -0.31 4.88e-9 PR interval in Tripanosoma cruzi seropositivity; CRC cis rs2739330 0.587 rs4820571 chr22:24242973 A/G cg18538332 chr22:24372958 LOC391322 -0.53 -7.57 -0.39 3.69e-13 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs13161895 1.000 rs4389651 chr5:179460968 T/A cg02702477 chr5:179499311 RNF130 0.54 6.22 0.32 1.52e-9 LDL cholesterol; CRC cis rs651907 0.557 rs7645391 chr3:101361506 C/G cg12386194 chr3:101231763 SENP7 0.48 6.84 0.35 3.96e-11 Colorectal cancer; CRC cis rs2279817 0.775 rs35493100 chr1:17993120 C/T cg21791023 chr1:18019539 ARHGEF10L -0.55 -6.15 -0.32 2.27e-9 Neuroticism; CRC cis rs780096 0.565 rs11681351 chr2:27743423 G/A cg27432699 chr2:27873401 GPN1 -0.64 -9.82 -0.48 4e-20 Total body bone mineral density; CRC cis rs4713118 0.513 rs149959 chr6:28013854 T/C cg10876282 chr6:28092338 ZSCAN16 0.49 6.61 0.34 1.56e-10 Parkinson's disease; CRC trans rs4711350 1.000 rs2395401 chr6:33759471 T/C cg14318858 chr19:50204862 CPT1C -0.37 -6.09 -0.32 3.21e-9 Schizophrenia; CRC cis rs858239 0.730 rs10255155 chr7:23402147 A/T cg00469287 chr7:23338798 C7orf30 -0.48 -6.38 -0.33 5.91e-10 Cerebrospinal fluid biomarker levels; CRC cis rs7618501 0.538 rs9856572 chr3:50109073 A/T cg05623727 chr3:50126028 RBM5 -0.44 -7.36 -0.38 1.52e-12 Intelligence (multi-trait analysis); CRC cis rs769267 0.930 rs10414830 chr19:19562332 C/T cg01262667 chr19:19385393 TM6SF2 0.37 6.05 0.32 3.94e-9 Tonsillectomy; CRC cis rs12048904 0.964 rs17123467 chr1:101331760 G/A cg16556008 chr1:101360663 SLC30A7;EXTL2 0.62 9.31 0.46 1.89e-18 Multiple sclerosis; CRC cis rs4073416 0.508 rs6573619 chr14:66061560 T/C cg03016385 chr14:66212404 NA -0.46 -6.31 -0.33 9e-10 N-glycan levels; CRC cis rs6988636 1.000 rs11988157 chr8:124194740 A/G cg27053337 chr8:124217698 FAM83A -0.4 -6.42 -0.33 4.84e-10 Urinary uromodulin levels; CRC cis rs4588572 0.643 rs13359053 chr5:77690224 T/C cg11547950 chr5:77652471 NA 0.55 7.68 0.39 1.78e-13 Triglycerides; CRC cis rs1475911 0.671 rs12483409 chr21:43521902 G/A cg19766460 chr21:43528205 UMODL1;C21orf128 0.96 14.47 0.62 4.59e-37 IgG glycosylation; CRC cis rs34779708 0.931 rs4934533 chr10:35359619 A/G cg03585969 chr10:35415529 CREM 0.58 7.81 0.4 7.99e-14 Inflammatory bowel disease;Crohn's disease; CRC cis rs45509595 0.841 rs200485 chr6:27775697 G/C cg03623178 chr6:28175578 NA 0.79 6.91 0.36 2.6e-11 Breast cancer; CRC trans rs11039798 0.698 rs76315297 chr11:48240475 T/C cg03929089 chr4:120376271 NA 0.71 6.93 0.36 2.26e-11 Axial length; CRC cis rs9329289 0.926 rs9329290 chr10:2542751 G/T cg05625103 chr10:2543513 NA 0.38 6.02 0.31 4.78e-9 Age-related hearing impairment; CRC cis rs561341 0.883 rs4450460 chr17:30201309 C/T cg00745463 chr17:30367425 LRRC37B 0.7 8.16 0.41 7.37e-15 Hip circumference adjusted for BMI; CRC cis rs7917772 0.636 rs2863718 chr10:104519631 G/C cg11453585 chr10:104263688 ACTR1A;SUFU -0.69 -10.29 -0.49 1.06e-21 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC cis rs1185460 0.967 rs1168568 chr11:118949799 G/A cg23280166 chr11:118938394 VPS11 0.43 6.33 0.33 8.21e-10 Coronary artery disease; CRC cis rs992157 0.732 rs10932771 chr2:219170236 A/T cg13835894 chr2:219148914 PNKD;TMBIM1 0.29 5.69 0.3 2.75e-8 Colorectal cancer; CRC cis rs478304 0.593 rs6591188 chr11:65467953 T/C cg27068330 chr11:65405492 SIPA1 -0.66 -9.82 -0.48 3.93e-20 Acne (severe); CRC cis rs875971 0.825 rs801202 chr7:66023929 C/T cg12463550 chr7:65579703 CRCP -0.47 -6.4 -0.33 5.38e-10 Aortic root size; CRC cis rs9303401 0.614 rs3087762 chr17:56568680 C/T cg10487724 chr17:56770010 TEX14;RAD51C 0.79 9.63 0.47 1.63e-19 Cognitive test performance; CRC trans rs561341 1.000 rs546519 chr17:30297682 T/G cg27661571 chr11:113659931 NA -0.77 -9.59 -0.47 2.24e-19 Hip circumference adjusted for BMI; CRC trans rs1120787 0.793 rs1153634 chr18:55014457 A/G cg19077231 chr7:100484514 SRRT 0.55 6.03 0.32 4.45e-9 HIV-1 control; CRC cis rs12760731 0.565 rs10913516 chr1:178169493 G/A cg00404053 chr1:178313656 RASAL2 1.11 11.5 0.54 6.02e-26 Obesity-related traits; CRC cis rs9322193 0.962 rs9505974 chr6:150100430 C/T cg05861140 chr6:150128134 PCMT1 -0.4 -6.58 -0.34 1.82e-10 Lung cancer; CRC cis rs7385804 0.633 rs221795 chr7:100283261 C/T cg20848291 chr7:100343083 ZAN 0.51 7.77 0.39 9.98e-14 Iron status biomarkers;Mean corpuscular hemoglobin;Hematocrit;Iron status biomarkers (transferrin saturation);Red blood cell count;Iron status biomarkers (iron levels);Mean corpuscular volume;Hematological parameters; CRC cis rs12024301 0.557 rs12039168 chr1:183638854 C/G cg11505048 chr1:183622726 RGL1;APOBEC4 0.81 7.06 0.36 1.01e-11 Peripheral arterial disease (traffic-related air pollution interaction); CRC trans rs1455244 0.700 rs7229302 chr18:11508904 G/T cg21440829 chr7:100808893 VGF 0.43 6.74 0.35 6.99e-11 Schizophrenia; CRC trans rs11098499 0.863 rs58452170 chr4:120459674 A/T cg25214090 chr10:38739885 LOC399744 0.65 10.46 0.5 2.74e-22 Corneal astigmatism; CRC cis rs6988985 0.693 rs7822986 chr8:143957856 G/A cg10324643 chr8:143916377 GML 0.36 5.98 0.31 5.66e-9 Plasma androstenedione levels in resected early stage-receptor positive breast cancer; CRC cis rs67311347 1.000 rs9817142 chr3:40425774 C/A cg24209194 chr3:40518798 ZNF619 0.4 5.62 0.3 4e-8 Renal cell carcinoma; CRC cis rs7715806 0.509 rs34349 chr5:74944868 A/G cg19683494 chr5:74908142 NA -0.58 -6.14 -0.32 2.32e-9 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs13064411 0.627 rs28536176 chr3:113143625 T/C cg10517650 chr3:113235015 CCDC52 -0.38 -6.04 -0.32 4.08e-9 Response to simvastatin treatment (PCSK9 protein level change); CRC cis rs1580019 0.562 rs4720064 chr7:32559638 G/A cg06627557 chr7:32535165 LSM5;AVL9 0.96 18.19 0.71 1.2e-51 Cognitive ability; CRC cis rs2153535 0.563 rs1737584 chr6:8536742 C/T cg21535247 chr6:8435926 SLC35B3 0.51 7.98 0.4 2.46e-14 Motion sickness; CRC trans rs11039798 0.688 rs8188953 chr11:48749201 A/T cg03929089 chr4:120376271 NA 0.63 6.06 0.32 3.73e-9 Axial length; CRC cis rs6952808 0.630 rs4719443 chr7:2161099 A/G cg20295408 chr7:1910781 MAD1L1 -0.43 -5.89 -0.31 9.54e-9 Bipolar disorder and schizophrenia; CRC cis rs35306767 0.714 rs66797613 chr10:1090469 C/T cg26597838 chr10:835615 NA 0.82 9.46 0.46 6.06e-19 Eosinophil percentage of granulocytes; CRC cis rs7249142 0.549 rs3787040 chr19:19297292 A/G cg08207377 chr19:19281140 LOC729991-MEF2B;MEF2B -0.35 -5.8 -0.3 1.52e-8 IgG glycosylation; CRC cis rs2839186 0.616 rs4819213 chr21:47619300 G/A cg13126279 chr21:47581558 C21orf56 0.38 6.09 0.32 3.22e-9 Testicular germ cell tumor; CRC cis rs1005277 0.579 rs11011461 chr10:38431427 G/A cg25427524 chr10:38739819 LOC399744 -0.77 -13.57 -0.6 1.23e-33 Extrinsic epigenetic age acceleration; CRC cis rs763014 0.932 rs2384974 chr16:651279 C/G cg09263875 chr16:632152 PIGQ 0.77 12.55 0.57 8.76e-30 Height; CRC cis rs13118159 0.778 rs12650998 chr4:1338832 T/C cg19318889 chr4:1322082 MAEA 0.41 6.18 0.32 1.92e-9 Longevity; CRC cis rs7246657 0.943 rs10422967 chr19:37850137 T/C cg23950597 chr19:37808831 NA -0.55 -6.52 -0.34 2.63e-10 Coronary artery calcification; CRC cis rs9341808 0.718 rs910266 chr6:80921170 A/T cg08355045 chr6:80787529 NA 0.43 6.94 0.36 2.08e-11 Sitting height ratio; CRC cis rs2559856 1.000 rs2559855 chr12:102090080 A/G cg12924262 chr12:102091054 CHPT1 -0.49 -7.44 -0.38 8.77e-13 Blood protein levels; CRC cis rs4073416 0.504 rs1953418 chr14:65915226 G/A cg03016385 chr14:66212404 NA -0.42 -5.78 -0.3 1.77e-8 N-glycan levels; CRC cis rs9488822 0.676 rs12524249 chr6:116368813 G/A cg05304507 chr6:116381966 FRK 0.3 8.06 0.41 1.45e-14 Cholesterol, total;LDL cholesterol; CRC cis rs4700695 0.668 rs166180 chr5:65499225 C/T cg21114390 chr5:65439923 SFRS12 -0.59 -7.85 -0.4 5.87e-14 Facial morphology (factor 19); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg17589079 chr11:67806437 TCIRG1 0.45 6.5 0.34 3.02e-10 Response to antipsychotic treatment; CRC cis rs9487051 0.604 rs9320282 chr6:109619377 A/G cg21918786 chr6:109611834 NA -0.42 -7.34 -0.38 1.71e-12 Reticulocyte fraction of red cells; CRC cis rs7208859 0.673 rs9891179 chr17:29208160 G/T cg01831904 chr17:28903510 LRRC37B2 -0.55 -5.77 -0.3 1.88e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs7236492 0.683 rs79747802 chr18:77198964 C/T cg15644404 chr18:77186268 NFATC1 -0.57 -5.87 -0.31 1.07e-8 Inflammatory bowel disease;Crohn's disease; CRC cis rs832540 0.629 rs3309 chr5:56092779 A/T cg12311346 chr5:56204834 C5orf35 0.49 7.48 0.38 6.89e-13 Coronary artery disease; CRC cis rs6496667 0.779 rs7175476 chr15:91027184 G/C cg04176472 chr15:90893244 GABARAPL3 0.53 7.8 0.39 8.38e-14 Rheumatoid arthritis; CRC cis rs1552244 0.554 rs13079240 chr3:10047246 C/T cg02579736 chr3:10068473 FANCD2;CIDECP 0.67 9.35 0.46 1.38e-18 Alzheimer's disease; CRC cis rs875971 0.862 rs11984115 chr7:65773859 C/T cg12463550 chr7:65579703 CRCP -0.5 -6.78 -0.35 5.73e-11 Aortic root size; CRC cis rs6691722 0.503 rs12135404 chr1:24704263 C/T cg02336364 chr1:24764700 NIPAL3 -0.37 -5.95 -0.31 6.93e-9 Response to interferon beta in multiple sclerosis; CRC cis rs826838 1.000 rs10880785 chr12:38655405 T/G cg13010199 chr12:38710504 ALG10B 0.46 6.1 0.32 2.98e-9 Heart rate; CRC cis rs7588746 0.868 rs12104649 chr2:201128832 C/T cg23649088 chr2:200775458 C2orf69 -0.5 -6.04 -0.32 4.18e-9 Bipolar disorder lithium response (continuous) or schizophrenia; CRC cis rs4242434 0.927 rs2272718 chr8:22457388 G/A cg03733263 chr8:22462867 KIAA1967 1.04 18.25 0.71 7.09e-52 Exploratory eye movement dysfunction in schizophrenia (cognitive search score); CRC trans rs35365539 1 rs35365539 chr3:49794347 A/AC cg21665057 chr3:196295764 WDR53;FBXO45 -0.86 -16.08 -0.66 2.34e-43 Blood protein levels; CRC cis rs2949837 0.581 rs1117457 chr7:45970037 G/A cg10677697 chr7:45961126 IGFBP3 0.34 6.01 0.31 5.03e-9 Sitting height ratio; CRC cis rs9322193 0.962 rs2342861 chr6:150098697 C/T cg05861140 chr6:150128134 PCMT1 -0.43 -7.05 -0.36 1.03e-11 Lung cancer; CRC cis rs9291683 0.527 rs3822247 chr4:10094671 G/A cg11266682 chr4:10021025 SLC2A9 -0.44 -8.22 -0.41 4.65e-15 Bone mineral density; CRC trans rs853679 0.546 rs200977 chr6:27854301 T/C cg16898833 chr6:26189333 HIST1H4D 0.73 6.37 0.33 6.51e-10 Depression; CRC cis rs8060686 0.641 rs12447931 chr16:68179195 C/T cg08314208 chr16:67682810 RLTPR -0.59 -6.28 -0.33 1.08e-9 HDL cholesterol;Metabolic syndrome; CRC cis rs4713118 0.955 rs9468200 chr6:27683063 T/A cg06470822 chr6:28175283 NA 0.68 8.91 0.44 3.6e-17 Parkinson's disease; CRC cis rs6952808 0.792 rs4721184 chr7:1950784 T/C cg02951883 chr7:2050386 MAD1L1 -0.7 -11.1 -0.52 1.53e-24 Bipolar disorder and schizophrenia; CRC cis rs10946940 0.965 rs6915266 chr6:27528643 G/A cg15845792 chr6:28175446 NA -0.48 -6.57 -0.34 2e-10 Systemic lupus erythematosus; CRC cis rs9322193 0.962 rs12175575 chr6:150084487 G/A cg00933542 chr6:150070202 PCMT1 0.28 5.69 0.3 2.75e-8 Lung cancer; CRC cis rs7849270 1.000 rs7868408 chr9:131917864 G/A cg13538475 chr9:131942899 NA -0.3 -5.78 -0.3 1.73e-8 Blood metabolite ratios; CRC cis rs3812762 0.783 rs34524863 chr11:8777408 T/C cg21881798 chr11:8931708 C11orf17;ST5 -0.42 -6.18 -0.32 1.95e-9 Hypospadias; CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg20959894 chr7:27779871 TAX1BP1 0.38 6.47 0.34 3.54e-10 Obesity-related traits; CRC cis rs9640161 0.659 rs11975886 chr7:150010362 G/A cg12556325 chr7:150026731 C7orf29;LRRC61 -0.43 -6.59 -0.34 1.75e-10 Blood protein levels;Circulating chemerin levels; CRC trans rs61931739 0.500 rs11052990 chr12:34058647 T/A cg26384229 chr12:38710491 ALG10B 0.53 6.77 0.35 5.85e-11 Morning vs. evening chronotype; CRC cis rs66569888 0.507 rs11673736 chr2:106886935 T/C cg23109721 chr2:106886537 NA -0.47 -7.39 -0.38 1.22e-12 Facial morphology (factor 23); CRC cis rs40363 0.671 rs4786425 chr16:3537650 A/G cg05754148 chr16:3507555 NAT15 -0.7 -6.75 -0.35 6.7e-11 Tuberculosis; CRC cis rs1577917 0.958 rs1838958 chr6:86563968 G/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.51 -6.59 -0.34 1.76e-10 Response to antipsychotic treatment; CRC cis rs6502050 0.835 rs8080625 chr17:80115447 G/A cg19223190 chr17:80058835 NA 0.39 6.25 0.33 1.27e-9 Life satisfaction; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg03364015 chr11:69454423 CCND1 0.47 6.04 0.32 4.26e-9 Anxiety disorder; CRC cis rs1707322 0.717 rs12023439 chr1:46104636 C/T cg06784218 chr1:46089804 CCDC17 0.65 12.14 0.56 2.91e-28 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs2836974 0.583 rs9981884 chr21:40585633 G/A cg17971929 chr21:40555470 PSMG1 0.48 6.71 0.35 8.54e-11 Cognitive function; CRC cis rs79349575 0.783 rs4794003 chr17:47029904 C/T cg00947319 chr17:47005597 UBE2Z -0.33 -5.67 -0.3 3.19e-8 Type 2 diabetes; CRC cis rs10979 1.000 rs9386036 chr6:143890709 A/G cg25407410 chr6:143891975 LOC285740 -0.82 -13.4 -0.59 5.5e-33 Hypospadias; CRC trans rs1973993 0.745 rs986427 chr1:96932736 A/G cg10631902 chr5:14652156 NA -0.42 -6.93 -0.36 2.27e-11 Weight; CRC cis rs10979 1.000 rs9403504 chr6:143885430 G/A cg25407410 chr6:143891975 LOC285740 -0.8 -13.03 -0.58 1.37e-31 Hypospadias; CRC cis rs17253792 0.822 rs8009239 chr14:56062490 A/G cg01858014 chr14:56050164 KTN1 -0.85 -6.72 -0.35 7.81e-11 Putamen volume; CRC cis rs853679 0.766 rs9368561 chr6:28168343 C/T cg15786705 chr6:28176104 NA 0.73 6.17 0.32 2.03e-9 Depression; CRC cis rs6743226 0.934 rs6705421 chr2:242212672 A/G cg10021735 chr2:242295487 FARP2 0.47 6.96 0.36 1.89e-11 Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI in non-smokers; CRC cis rs644799 0.542 rs10831417 chr11:95467262 A/G cg03916912 chr11:95522834 CEP57;FAM76B -0.66 -10.14 -0.49 3.23e-21 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs6684514 0.922 rs11264475 chr1:156306918 G/A cg16558208 chr1:156270281 VHLL 0.56 8.76 0.43 1.06e-16 Mean corpuscular hemoglobin concentration;Glycated hemoglobin levels; CRC cis rs7208859 0.623 rs9911173 chr17:29154750 C/T cg13385521 chr17:29058706 SUZ12P 0.64 7.34 0.38 1.63e-12 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs7811142 0.720 rs112622797 chr7:99917416 G/A cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.62 7.66 0.39 2.09e-13 Platelet count; CRC cis rs1799949 1.000 rs36036395 chr17:41181297 T/C cg19454999 chr17:41278357 BRCA1;NBR2 0.53 8.09 0.41 1.2e-14 Menopause (age at onset); CRC cis rs1799949 0.965 rs4793233 chr17:41435437 G/C cg19454999 chr17:41278357 BRCA1;NBR2 0.52 8.07 0.41 1.33e-14 Menopause (age at onset); CRC cis rs9443645 0.527 rs2105143 chr6:79742947 G/A cg05283184 chr6:79620031 NA -0.45 -6.46 -0.34 3.82e-10 Intelligence (multi-trait analysis); CRC trans rs916888 0.773 rs199535 chr17:44822662 A/G cg22968622 chr17:43663579 NA 1.4 19.03 0.72 5.7e-55 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs4268898 0.686 rs2042468 chr2:24398446 A/T cg26838691 chr2:24397539 C2orf84 0.41 5.72 0.3 2.34e-8 Asthma; CRC cis rs4727963 0.792 rs6466853 chr7:122719094 C/A cg03640110 chr7:122635026 TAS2R16 -0.32 -5.92 -0.31 8.31e-9 Adverse response to chemotherapy (neutropenia/leucopenia) (docetaxel); CRC trans rs875971 0.660 rs2191268 chr7:66110224 C/T cg23109191 chr11:78128445 GAB2 -0.39 -6.0 -0.31 5.32e-9 Aortic root size; CRC cis rs12931792 0.712 rs4787495 chr16:30165725 C/T cg17640201 chr16:30407289 ZNF48 -0.4 -5.82 -0.31 1.41e-8 Tonsillectomy; CRC cis rs651907 0.557 rs35850993 chr3:101437433 A/G cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.63 8.66 0.43 2.14e-16 Colorectal cancer; CRC cis rs3106136 0.967 rs2129595 chr4:95224454 G/A cg11021082 chr4:95130006 SMARCAD1 -0.46 -7.09 -0.36 8.28e-12 Capecitabine sensitivity; CRC cis rs9910055 0.676 rs11079983 chr17:42198170 C/T cg10896456 chr17:42255109 ASB16;C17orf65 0.44 7.23 0.37 3.42e-12 Total body bone mineral density; CRC cis rs853679 0.517 rs56310871 chr6:28044482 A/G cg18032046 chr6:28092343 ZSCAN16 -0.5 -5.89 -0.31 9.74e-9 Depression; CRC cis rs1862618 0.853 rs832551 chr5:56180112 T/G cg12311346 chr5:56204834 C5orf35 -0.79 -10.04 -0.48 7.48e-21 Initial pursuit acceleration; CRC cis rs1799949 1.000 rs11653231 chr17:41331460 G/A cg01879757 chr17:41196368 BRCA1 -0.44 -6.69 -0.35 9.41e-11 Menopause (age at onset); CRC cis rs883565 0.740 rs6780772 chr3:39087764 A/G cg01426195 chr3:39028469 NA -0.53 -8.54 -0.43 4.97e-16 Handedness; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg10117518 chr2:29117384 WDR43 0.39 6.15 0.32 2.29e-9 Liver disease severity in Alagille syndrome; CRC cis rs7917772 0.532 rs10748829 chr10:104527244 G/A cg04362960 chr10:104952993 NT5C2 0.46 6.11 0.32 2.84e-9 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg21687924 chr11:3400496 ZNF195 0.42 6.2 0.32 1.64e-9 Intelligence (multi-trait analysis); CRC cis rs35306767 0.903 rs12244253 chr10:889320 G/T cg20503657 chr10:835505 NA 0.91 11.11 0.52 1.41e-24 Eosinophil percentage of granulocytes; CRC trans rs2727020 0.521 rs11040377 chr11:49474346 T/C cg03929089 chr4:120376271 NA -0.7 -11.27 -0.53 3.86e-25 Coronary artery disease; CRC cis rs9905704 0.846 rs302877 chr17:56764018 G/A cg12560992 chr17:57184187 TRIM37 0.57 8.26 0.41 3.65e-15 Testicular germ cell tumor; CRC cis rs1862618 0.802 rs832560 chr5:56124423 T/A cg24531977 chr5:56204891 C5orf35 -0.78 -10.78 -0.51 2.15e-23 Initial pursuit acceleration; CRC trans rs3960554 0.808 rs79864016 chr7:75655838 A/G cg19862616 chr7:65841803 NCRNA00174 0.69 8.09 0.41 1.15e-14 Eotaxin levels; CRC cis rs75422866 0.510 rs73105829 chr12:48127945 A/C cg14736327 chr12:48174669 SLC48A1 -0.77 -6.26 -0.33 1.22e-9 Pneumonia; CRC cis rs6502050 0.835 rs67149434 chr17:80128007 G/A cg25804541 chr17:80189381 SLC16A3 -0.3 -5.84 -0.31 1.23e-8 Life satisfaction; CRC cis rs514406 0.644 rs7530078 chr1:53204861 G/T cg25767906 chr1:53392781 SCP2 0.37 5.86 0.31 1.12e-8 Monocyte count; CRC cis rs10504073 0.647 rs2292399 chr8:49987230 A/G cg00325661 chr8:49890786 NA 0.52 9.23 0.45 3.37e-18 Blood metabolite ratios; CRC cis rs11676348 0.805 rs13007219 chr2:218963859 C/A cg00012203 chr2:219082015 ARPC2 -0.38 -5.73 -0.3 2.22e-8 Ulcerative colitis; CRC cis rs9640161 0.750 rs11765644 chr7:150026339 C/G cg12556325 chr7:150026731 C7orf29;LRRC61 -0.49 -7.33 -0.37 1.81e-12 Blood protein levels;Circulating chemerin levels; CRC trans rs10842750 1.000 rs10842750 chr12:26690565 G/T cg18404039 chr20:3184938 DDRGK1 0.52 6.22 0.32 1.48e-9 Kashin-Beck disease; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg11039072 chr15:35280907 ZNF770 0.51 6.68 0.35 1.04e-10 Thyroid stimulating hormone; CRC cis rs13064411 0.627 rs28536176 chr3:113143625 T/C cg18753928 chr3:113234510 CCDC52 -0.63 -8.71 -0.43 1.52e-16 Response to simvastatin treatment (PCSK9 protein level change); CRC cis rs28386778 0.897 rs9906247 chr17:61857314 T/C cg22520471 chr17:61851767 DDX42;CCDC47 0.76 11.75 0.54 7.66e-27 Prudent dietary pattern; CRC cis rs4629710 0.592 rs10484763 chr6:131549060 T/C cg12606694 chr6:131520996 AKAP7 0.54 8.06 0.41 1.39e-14 Multiple myeloma (IgH translocation); CRC cis rs2204008 0.774 rs11520237 chr12:38266978 G/A cg13010199 chr12:38710504 ALG10B 0.44 5.73 0.3 2.33e-8 Bladder cancer; CRC cis rs1552244 0.882 rs17081288 chr3:10042113 A/G cg08888203 chr3:10149979 C3orf24 0.64 8.64 0.43 2.5e-16 Alzheimer's disease; CRC cis rs11628318 0.614 rs942022 chr14:103108842 C/T cg23461800 chr14:103021989 NA -0.68 -7.91 -0.4 3.86e-14 Platelet count; CRC cis rs11148252 0.538 rs2296349 chr13:52710058 T/G cg12458913 chr13:53173898 NA 0.46 6.81 0.35 4.53e-11 Lewy body disease; CRC cis rs11190604 1.000 rs11190551 chr10:102204734 A/G cg16342193 chr10:102329863 NA -0.35 -5.83 -0.31 1.29e-8 Palmitoleic acid (16:1n-7) levels; CRC cis rs2153535 0.584 rs55945625 chr6:8371367 C/T cg21535247 chr6:8435926 SLC35B3 -0.41 -6.0 -0.31 5.22e-9 Motion sickness; CRC cis rs1448094 0.527 rs1900700 chr12:86232166 C/T cg19622623 chr12:86230825 RASSF9 -0.4 -6.31 -0.33 9.21e-10 Major depressive disorder; CRC cis rs11098499 0.874 rs6851169 chr4:120117510 T/C cg24375607 chr4:120327624 NA 0.48 7.25 0.37 3.02e-12 Corneal astigmatism; CRC cis rs13098911 0.540 rs13074382 chr3:46061840 A/G cg12691230 chr3:46064611 XCR1 -0.52 -5.82 -0.31 1.41e-8 Celiac disease; CRC cis rs703842 1.000 rs10877014 chr12:58167661 A/G cg04478727 chr12:58166393 METTL1;FAM119B 0.41 5.66 0.3 3.22e-8 Multiple sclerosis; CRC trans rs1005277 0.563 rs2505216 chr10:38482830 T/C cg27523141 chr10:43048294 ZNF37B 0.47 6.74 0.35 7.02e-11 Extrinsic epigenetic age acceleration; CRC cis rs801193 0.613 rs2659900 chr7:66184443 G/C cg11764359 chr7:65958608 NA 0.6 9.3 0.46 2.03e-18 Aortic root size; CRC cis rs10256972 0.630 rs13235747 chr7:1129123 T/C cg23978390 chr7:1156363 C7orf50 0.52 7.28 0.37 2.51e-12 Longevity;Endometriosis; CRC cis rs7617773 0.780 rs13090538 chr3:48370769 A/C cg11946769 chr3:48343235 NME6 0.7 9.2 0.45 4.3e-18 Coronary artery disease; CRC cis rs9372498 0.536 rs9489436 chr6:118873817 A/C cg01339444 chr6:118972232 C6orf204 0.53 6.03 0.32 4.29e-9 Diastolic blood pressure; CRC cis rs546131 0.928 rs483976 chr11:34840167 C/G cg06937548 chr11:34938143 PDHX;APIP 0.39 5.99 0.31 5.36e-9 Lung disease severity in cystic fibrosis; CRC cis rs597539 0.652 rs654071 chr11:68653432 A/C cg21963583 chr11:68658836 MRPL21 0.63 11.52 0.54 5.02e-26 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs9463078 0.683 rs1342640 chr6:44743516 T/C cg25276700 chr6:44698697 NA 0.25 5.95 0.31 6.9e-9 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; CRC cis rs9291683 0.610 rs993172 chr4:10324361 G/T cg11266682 chr4:10021025 SLC2A9 0.43 8.2 0.41 5.48e-15 Bone mineral density; CRC trans rs2689154 1.000 rs2689154 chr1:238908353 C/G cg21368352 chr6:424126 NA -0.4 -6.04 -0.32 4.12e-9 Pancreatic cancer; CRC cis rs1129187 0.755 rs4714638 chr6:42917017 A/G cg02359409 chr6:42947317 PEX6 -0.65 -10.33 -0.49 7.58e-22 Alzheimer's disease in APOE e4+ carriers; CRC cis rs10540 0.686 rs12421266 chr11:537120 C/T cg19913688 chr11:428466 ANO9 -0.65 -6.58 -0.34 1.83e-10 Body mass index; CRC cis rs4660306 0.614 rs12032658 chr1:45923851 C/G cg03123370 chr1:45965343 CCDC163P;MMACHC 0.51 6.76 0.35 6.49e-11 Homocysteine levels; CRC cis rs9640161 0.742 rs11983355 chr7:150016697 A/C cg12556325 chr7:150026731 C7orf29;LRRC61 -0.41 -6.05 -0.32 3.99e-9 Blood protein levels;Circulating chemerin levels; CRC cis rs7843479 0.562 rs6988010 chr8:21859084 G/A cg17168535 chr8:21777572 XPO7 0.6 9.93 0.48 1.68e-20 Mean corpuscular volume; CRC cis rs870825 0.872 rs12507711 chr4:185571776 C/T cg04058563 chr4:185651563 MLF1IP 0.61 6.6 0.34 1.63e-10 Blood protein levels; CRC cis rs8180040 0.966 rs13075233 chr3:47420627 T/C cg02527881 chr3:46936655 PTH1R -0.39 -7.45 -0.38 8.43e-13 Colorectal cancer; CRC cis rs9733 0.596 rs12403255 chr1:150660412 C/T cg17724175 chr1:150552817 MCL1 0.58 9.31 0.46 1.84e-18 Tonsillectomy; CRC cis rs9916302 0.861 rs11658219 chr17:37709782 G/A cg15445000 chr17:37608096 MED1 0.39 8.36 0.42 1.79e-15 Glomerular filtration rate (creatinine); CRC cis rs7223966 1.000 rs7223672 chr17:61720565 T/C cg23090583 chr17:61904693 PSMC5;FTSJ3 0.47 5.92 0.31 7.91e-9 Hip circumference adjusted for BMI;Body mass index; CRC cis rs4730250 0.707 rs257387 chr7:106808480 G/A cg02696742 chr7:106810147 HBP1 -0.65 -6.93 -0.36 2.28e-11 Osteoarthritis; CRC trans rs9987353 0.840 rs41436744 chr8:9123324 C/T cg06636001 chr8:8085503 FLJ10661 -0.46 -6.45 -0.34 4.06e-10 Recombination measurement; CRC cis rs864537 0.676 rs2056625 chr1:167420299 G/A cg22356347 chr1:167427500 CD247 -0.4 -6.08 -0.32 3.28e-9 Celiac disease or Rheumatoid arthritis;Celiac disease; CRC cis rs7177699 0.557 rs8026598 chr15:79112938 A/G cg15571903 chr15:79123663 NA 0.31 6.14 0.32 2.38e-9 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; CRC cis rs1448094 0.967 rs7961782 chr12:86326461 T/C cg19622623 chr12:86230825 RASSF9 -0.35 -5.69 -0.3 2.8e-8 Major depressive disorder; CRC trans rs1814175 0.592 rs1794161 chr11:49898825 A/C cg15704280 chr7:45808275 SEPT13 -0.94 -16.79 -0.68 3.96e-46 Height; CRC cis rs2952156 0.920 rs11078919 chr17:37835755 T/C cg11212589 chr17:38028394 ZPBP2 0.34 6.02 0.32 4.62e-9 Asthma; CRC cis rs2949837 0.603 rs1542818 chr7:45977656 G/T cg15898840 chr7:45960834 IGFBP3 0.45 7.4 0.38 1.12e-12 Sitting height ratio; CRC cis rs597539 0.652 rs674654 chr11:68698762 G/T cg21963583 chr11:68658836 MRPL21 0.59 10.51 0.5 1.75e-22 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs897984 0.571 rs7184567 chr16:31021078 C/T cg02466173 chr16:30829666 NA -0.62 -9.4 -0.46 9.91e-19 Dementia with Lewy bodies; CRC cis rs1552244 0.872 rs115331527 chr3:10154504 G/A cg00166722 chr3:10149974 C3orf24 0.73 9.61 0.47 1.95e-19 Alzheimer's disease; CRC cis rs2933343 0.729 rs1680780 chr3:128612659 G/C cg25356066 chr3:128598488 ACAD9 0.39 5.66 0.3 3.22e-8 IgG glycosylation; CRC cis rs7552404 0.924 rs1146579 chr1:76209792 C/T cg10523679 chr1:76189770 ACADM -0.77 -11.56 -0.54 3.52e-26 Blood metabolite levels;Acylcarnitine levels; CRC cis rs4713118 0.597 rs172166 chr6:28020820 C/G cg03623178 chr6:28175578 NA 0.88 12.69 0.57 2.62e-30 Parkinson's disease; CRC trans rs8064024 0.538 rs12596053 chr16:4946794 A/C cg19252218 chr17:41477271 ARL4D -0.41 -6.05 -0.32 3.93e-9 Cancer; CRC cis rs9292777 0.805 rs6880778 chr5:40399096 A/G cg09067459 chr5:40385259 NA 0.54 9.47 0.46 5.67e-19 Crohn's disease;Multiple sclerosis; CRC trans rs7615952 0.576 rs2276729 chr3:125826214 G/A cg07211511 chr3:129823064 LOC729375 -0.67 -9.29 -0.46 2.13e-18 Blood pressure (smoking interaction); CRC cis rs916888 0.821 rs199512 chr17:44857352 T/C cg15921436 chr17:44337874 NA -0.68 -7.81 -0.4 7.78e-14 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs736408 0.716 rs2239549 chr3:52823126 C/T cg18404041 chr3:52824283 ITIH1 -0.46 -9.24 -0.45 3.2e-18 Bipolar disorder; CRC cis rs4713118 0.869 rs9348775 chr6:27695329 C/T cg03623178 chr6:28175578 NA 0.65 9.04 0.45 1.34e-17 Parkinson's disease; CRC cis rs3796352 0.892 rs9756317 chr3:53088815 T/C cg06204229 chr3:52865917 ITIH4 -0.47 -5.87 -0.31 1.05e-8 Immune reponse to smallpox (secreted IL-2); CRC cis rs11628318 0.853 rs8003309 chr14:103050143 C/G cg23071808 chr14:103021642 NA -0.7 -8.95 -0.44 2.72e-17 Platelet count; CRC cis rs9649213 0.593 rs6949214 chr7:97960233 G/A cg00277769 chr7:97922759 BAIAP2L1 -0.61 -10.65 -0.51 5.74e-23 Prostate cancer (SNP x SNP interaction); CRC trans rs1656966 1.000 rs1656966 chr3:186466252 C/T cg04722249 chr2:97617061 FAM178B 0.4 6.34 0.33 7.74e-10 Myopia (pathological); CRC cis rs970548 0.908 rs11239538 chr10:45994596 G/C cg15590007 chr10:45870220 ALOX5 0.48 6.04 0.32 4.24e-9 Total cholesterol levels;Cholesterol, total;HDL cholesterol;HDL cholesterol levels; CRC cis rs921968 0.643 rs832799 chr2:219490111 C/A cg02176678 chr2:219576539 TTLL4 0.5 8.37 0.42 1.72e-15 Mean corpuscular hemoglobin concentration; CRC cis rs629535 0.814 rs62513376 chr8:70086881 C/T cg26132723 chr8:70041827 NA -0.35 -5.61 -0.3 4.27e-8 Dupuytren's disease; CRC cis rs8010715 1.000 rs8010715 chr14:24609147 T/C cg23112188 chr14:24563095 PCK2 -0.35 -6.46 -0.34 3.7e-10 IgG glycosylation; CRC cis rs1348850 0.513 rs6730406 chr2:178492722 C/T cg27490568 chr2:178487706 NA 0.41 5.86 0.31 1.1e-8 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs2952156 0.920 rs2517959 chr17:37846512 A/T cg00129232 chr17:37814104 STARD3 -0.72 -12.14 -0.56 2.83e-28 Asthma; CRC cis rs3749237 0.929 rs62260715 chr3:49829326 G/A cg03060546 chr3:49711283 APEH 0.57 8.38 0.42 1.54e-15 Resting heart rate; CRC cis rs801193 0.773 rs801207 chr7:66020590 T/C cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.43 -6.39 -0.33 5.66e-10 Aortic root size; CRC cis rs4332037 0.851 rs34040190 chr7:1920356 G/A cg02421172 chr7:1938701 MAD1L1 0.44 5.71 0.3 2.5e-8 Bipolar disorder; CRC cis rs60871478 0.786 rs55899111 chr7:827843 C/G cg13798912 chr7:905769 UNC84A -0.5 -5.67 -0.3 3.11e-8 Cerebrospinal P-tau181p levels; CRC cis rs6963495 0.818 rs55691539 chr7:105165774 T/C cg02135003 chr7:105160482 PUS7 -0.91 -12.41 -0.56 2.87e-29 Bipolar disorder (body mass index interaction); CRC cis rs7615952 0.932 rs7630077 chr3:125649676 T/C cg05084668 chr3:125655381 ALG1L -0.63 -9.83 -0.48 3.57e-20 Blood pressure (smoking interaction); CRC cis rs853679 0.517 rs9348793 chr6:28084189 G/A cg15786705 chr6:28176104 NA 0.76 9.47 0.46 5.57e-19 Depression; CRC trans rs1455244 0.700 rs7229302 chr18:11508904 G/T cg26959990 chr15:23034449 NIPA2 0.44 6.59 0.34 1.78e-10 Schizophrenia; CRC cis rs3760982 0.967 rs3760984 chr19:44286762 C/T cg11993925 chr19:44307056 LYPD5 0.47 7.74 0.39 1.24e-13 Breast cancer (estrogen-receptor negative);Breast cancer; CRC cis rs7772486 0.817 rs9322047 chr6:146400394 G/A cg13319975 chr6:146136371 FBXO30 -0.39 -6.09 -0.32 3.18e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs796364 0.951 rs281769 chr2:200809709 T/C cg25936922 chr2:200820526 C2orf60;C2orf47 0.7 7.64 0.39 2.33e-13 Schizophrenia; CRC cis rs11577318 0.853 rs4526602 chr1:26648034 C/T cg00852783 chr1:26633632 UBXN11 0.48 6.76 0.35 6.41e-11 Granulocyte percentage of myeloid white cells; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg24664570 chr2:159825143 TANC1 0.41 6.81 0.35 4.62e-11 Liver disease severity in Alagille syndrome; CRC cis rs113123495 0.609 rs2436502 chr19:5645444 G/A cg26242866 chr19:5711310 LONP1 0.75 6.14 0.32 2.36e-9 Obsessive-compulsive symptoms; CRC cis rs7258465 1.000 rs8109573 chr19:18617151 G/T cg06462663 chr19:18546047 ISYNA1 0.48 7.22 0.37 3.58e-12 Breast cancer; CRC trans rs6601327 0.518 rs13264850 chr8:9575331 A/T cg16141378 chr3:129829833 LOC729375 0.42 5.98 0.31 5.8e-9 Multiple myeloma (hyperdiploidy); CRC cis rs10504229 0.593 rs7000752 chr8:58026980 C/G cg22535103 chr8:58192502 C8orf71 -0.43 -5.75 -0.3 2e-8 Developmental language disorder (linguistic errors); CRC cis rs9640161 0.750 rs73170185 chr7:150030191 C/A cg13722127 chr7:150037890 RARRES2 0.48 7.48 0.38 6.81e-13 Blood protein levels;Circulating chemerin levels; CRC cis rs9522267 0.535 rs11069897 chr13:112231319 A/G cg10483660 chr13:112241077 NA -0.47 -8.67 -0.43 1.97e-16 Hepatitis; CRC cis rs7605827 0.930 rs1019359 chr2:15524615 T/C cg19274914 chr2:15703543 NA 0.39 5.9 0.31 8.92e-9 Educational attainment (years of education); CRC cis rs9309473 0.687 rs6747145 chr2:73609177 C/T cg20560298 chr2:73613845 ALMS1 -0.52 -7.24 -0.37 3.21e-12 Metabolite levels; CRC cis rs17162190 0.590 rs7524421 chr1:26810612 C/G cg17456097 chr1:26900765 RPS6KA1 0.44 6.36 0.33 6.79e-10 Mean corpuscular volume; CRC cis rs2576037 0.526 rs10853547 chr18:44530548 A/C cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.51 8.25 0.41 3.95e-15 Personality dimensions; CRC cis rs9486719 1.000 rs10457159 chr6:96993139 G/A cg18709589 chr6:96969512 KIAA0776 -0.53 -5.98 -0.31 5.81e-9 Migraine;Coronary artery disease; CRC trans rs10838798 0.504 rs11039632 chr11:48297280 C/T cg03929089 chr4:120376271 NA -0.46 -6.53 -0.34 2.55e-10 Height; CRC cis rs9649213 0.593 rs6465677 chr7:98003552 C/T cg24562669 chr7:97807699 LMTK2 0.42 6.95 0.36 2.01e-11 Prostate cancer (SNP x SNP interaction); CRC cis rs4237845 0.611 rs7298370 chr12:58318897 C/T cg00677455 chr12:58241039 CTDSP2 0.39 5.67 0.3 3.12e-8 Intelligence (multi-trait analysis); CRC cis rs17345786 0.906 rs58835747 chr3:101243634 T/C cg12386194 chr3:101231763 SENP7 0.53 6.78 0.35 5.57e-11 Colonoscopy-negative controls vs population controls; CRC cis rs17767392 0.595 rs4902918 chr14:71656732 A/G cg13720639 chr14:72061746 SIPA1L1 -0.48 -6.15 -0.32 2.24e-9 Mitral valve prolapse; CRC trans rs679582 0.864 rs4896469 chr6:139843787 A/G cg24871798 chr6:50817450 NA -0.36 -6.29 -0.33 1.01e-9 Blood trace element (Se levels); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg06396948 chr16:67193897 FBXL8;TRADD 0.45 6.58 0.34 1.88e-10 Intelligence (multi-trait analysis); CRC cis rs6693567 0.586 rs12031973 chr1:150485566 T/G cg04165759 chr1:150448943 RPRD2 0.36 5.87 0.31 1.06e-8 Migraine; CRC cis rs5753037 0.543 rs140128 chr22:30150140 T/C cg01021169 chr22:30184971 ASCC2 -0.37 -5.68 -0.3 2.93e-8 Type 1 diabetes; CRC cis rs4481887 0.927 rs10749646 chr1:248429719 A/G cg13385794 chr1:248469461 NA -0.4 -6.87 -0.35 3.19e-11 Common traits (Other); CRC cis rs7246657 0.943 rs2891699 chr19:37920237 A/G cg23950597 chr19:37808831 NA -0.49 -6.09 -0.32 3.18e-9 Coronary artery calcification; CRC cis rs11229555 0.645 rs11229428 chr11:58180382 C/T cg15696309 chr11:58395628 NA -0.81 -10.29 -0.49 1.02e-21 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; CRC cis rs6502050 0.764 rs35713597 chr17:80119016 C/G cg02741985 chr17:80059408 CCDC57 0.43 7.15 0.37 5.59e-12 Life satisfaction; CRC cis rs4268898 0.662 rs72795824 chr2:24435837 T/C cg06627628 chr2:24431161 ITSN2 -0.85 -11.58 -0.54 3.01e-26 Asthma; CRC cis rs561341 1.000 rs535151 chr17:30317405 C/T cg23018236 chr17:30244563 NA -0.47 -6.63 -0.34 1.42e-10 Hip circumference adjusted for BMI; CRC cis rs2730260 0.500 rs73169244 chr7:158887293 T/C cg02254261 chr7:158964346 NA -0.54 -6.19 -0.32 1.8e-9 Myopia (pathological); CRC cis rs2404602 0.735 rs2461870 chr15:76813920 T/G cg23625390 chr15:77176239 SCAPER -0.75 -12.27 -0.56 9.78e-29 Blood metabolite levels; CRC cis rs11628318 0.803 rs2277468 chr14:103024080 A/G cg23071808 chr14:103021642 NA -0.68 -8.71 -0.43 1.55e-16 Platelet count; CRC cis rs1008375 1.000 rs11737138 chr4:17657986 G/A cg04450456 chr4:17643702 FAM184B 0.41 6.62 0.34 1.47e-10 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs11239930 0.934 rs10900313 chr1:146560747 T/A cg11655389 chr1:146548469 NA -0.32 -5.72 -0.3 2.41e-8 AIDS progression; CRC cis rs6543140 0.964 rs2141781 chr2:103082906 G/A cg03938978 chr2:103052716 IL18RAP 0.41 6.52 0.34 2.71e-10 Blood protein levels; CRC cis rs10924970 1.000 rs10924501 chr1:235351447 G/A cg26050004 chr1:235667680 B3GALNT2 0.39 5.76 0.3 1.92e-8 Asthma; CRC cis rs9649213 0.593 rs6465682 chr7:98016417 C/A cg21770322 chr7:97807741 LMTK2 0.53 8.63 0.43 2.63e-16 Prostate cancer (SNP x SNP interaction); CRC trans rs7395662 1.000 rs11039819 chr11:48562181 G/T cg21153622 chr11:89784906 NA -0.45 -7.13 -0.37 6.32e-12 HDL cholesterol; CRC cis rs9814567 1.000 rs6439484 chr3:134249899 A/G cg06109529 chr3:134205091 CEP63;ANAPC13 -0.81 -12.16 -0.56 2.46e-28 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC trans rs8123881 0.733 rs7268466 chr20:15810676 C/T cg01412321 chr7:36429799 ANLN;KIAA0895 0.57 6.14 0.32 2.36e-9 Body mass index; CRC cis rs701145 0.556 rs355779 chr3:153977253 T/C cg16511985 chr3:153974050 SGEF 0.44 5.81 0.31 1.47e-8 Coronary artery disease; CRC cis rs7772486 0.875 rs2814877 chr6:146299763 C/G cg23711669 chr6:146136114 FBXO30 0.69 11.86 0.55 2.88e-27 Lobe attachment (rater-scored or self-reported); CRC cis rs875971 0.862 rs801209 chr7:66019390 G/T cg18876405 chr7:65276391 NA -0.52 -8.38 -0.42 1.6e-15 Aortic root size; CRC cis rs1348850 0.651 rs1901824 chr2:178225466 T/C cg22681709 chr2:178499509 PDE11A -0.33 -5.92 -0.31 8.17e-9 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs245880 0.740 rs245889 chr7:29190626 C/T cg17163760 chr7:29186267 CPVL -0.39 -6.89 -0.35 2.9100000000000002e-11 Warfarin maintenance dose; CRC cis rs861020 1.000 rs622832 chr1:209974232 A/C cg09163369 chr1:210001066 C1orf107 0.56 7.59 0.39 3.41e-13 Orofacial clefts; CRC cis rs703980 0.967 rs703972 chr10:80952826 G/C cg20744163 chr10:80999841 ZMIZ1 0.31 5.74 0.3 2.16e-8 Type 2 diabetes; CRC cis rs6918586 0.636 rs198816 chr6:26127184 C/T cg18357526 chr6:26021779 HIST1H4A -0.5 -7.47 -0.38 7.38e-13 Schizophrenia; CRC cis rs9942416 0.660 rs67803720 chr5:74984408 A/T cg19683494 chr5:74908142 NA 0.51 6.46 0.34 3.67e-10 Age-related disease endophenotypes; CRC trans rs62103177 0.636 rs9958792 chr18:77627876 T/C cg05926928 chr17:57297772 GDPD1 -0.52 -6.05 -0.32 3.96e-9 Opioid sensitivity; CRC cis rs780096 0.526 rs7594812 chr2:27611469 A/G cg22903471 chr2:27725779 GCKR -0.37 -6.08 -0.32 3.27e-9 Total body bone mineral density; CRC cis rs1387259 0.929 rs11168460 chr12:48597365 A/G cg21466736 chr12:48725269 NA -0.53 -8.06 -0.41 1.47e-14 Obstructive sleep apnea trait (apnea hypopnea index); CRC trans rs7618501 0.699 rs6446187 chr3:49907111 C/A cg21665057 chr3:196295764 WDR53;FBXO45 0.65 10.3 0.49 9.16e-22 Intelligence (multi-trait analysis); CRC trans rs9467711 0.606 rs2072806 chr6:26385093 C/G cg06606381 chr12:133084897 FBRSL1 -0.8 -5.99 -0.31 5.51e-9 Autism spectrum disorder or schizophrenia; CRC cis rs2976388 0.609 rs2244152 chr8:143784885 C/A cg22687807 chr8:143858763 LYNX1 0.51 9.08 0.45 1e-17 Urinary tract infection frequency; CRC cis rs116095464 0.558 rs10057299 chr5:242135 C/T cg22857025 chr5:266934 NA -1.25 -16.72 -0.68 7.27e-46 Breast cancer; CRC cis rs7731657 0.537 rs4705924 chr5:130210792 G/A cg08523029 chr5:130500466 HINT1 -0.48 -6.14 -0.32 2.44e-9 Fasting plasma glucose; CRC cis rs2882667 0.728 rs7722413 chr5:138278251 T/C cg09476006 chr5:138032270 NA 0.58 10.02 0.48 8.25e-21 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs9291683 0.605 rs73224439 chr4:10331818 C/A cg00071950 chr4:10020882 SLC2A9 -0.51 -8.3 -0.42 2.68e-15 Bone mineral density; CRC cis rs17253792 0.822 rs78429067 chr14:56092551 G/A cg01858014 chr14:56050164 KTN1 -0.87 -7.23 -0.37 3.34e-12 Putamen volume; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg11117896 chr2:220094984 ANKZF1;ATG9A 0.55 7.2 0.37 4.07e-12 Thyroid stimulating hormone; CRC trans rs1005277 0.579 rs2504140 chr10:38387579 T/G cg23533926 chr12:111358616 MYL2 -0.52 -7.84 -0.4 6.17e-14 Extrinsic epigenetic age acceleration; CRC cis rs6860806 0.507 rs270606 chr5:131650867 A/G cg18301423 chr5:131593218 PDLIM4 0.41 6.79 0.35 5.39e-11 Breast cancer; CRC trans rs7395662 1.000 rs4882120 chr11:48573529 C/T cg21153622 chr11:89784906 NA -0.44 -7.1 -0.36 7.56e-12 HDL cholesterol; CRC cis rs354033 1.000 rs354042 chr7:149297104 A/G cg24335155 chr7:149193227 ZNF746 0.37 5.84 0.31 1.29e-8 Multiple sclerosis; CRC cis rs651907 0.535 rs13085776 chr3:101505507 A/G cg11279151 chr3:101281821 RG9MTD1 -0.54 -7.01 -0.36 1.33e-11 Colorectal cancer; CRC cis rs6912958 0.559 rs242287 chr6:88071825 C/T cg04972856 chr6:88032051 C6orf162;GJB7 0.3 5.62 0.3 3.97e-8 Monocyte percentage of white cells; CRC cis rs875971 1.000 rs6460292 chr7:65810075 G/A cg18876405 chr7:65276391 NA -0.52 -9.03 -0.45 1.44e-17 Aortic root size; CRC trans rs61931739 0.534 rs1817761 chr12:34105719 C/T cg26384229 chr12:38710491 ALG10B 0.54 6.95 0.36 1.99e-11 Morning vs. evening chronotype; CRC cis rs853679 0.882 rs9461432 chr6:28086883 T/C cg06470822 chr6:28175283 NA 0.81 6.57 0.34 2.03e-10 Depression; CRC cis rs769267 0.930 rs7254927 chr19:19404786 C/G cg01262667 chr19:19385393 TM6SF2 0.37 6.17 0.32 2.05e-9 Tonsillectomy; CRC cis rs13108904 0.557 rs1250086 chr4:1248051 G/A cg20887711 chr4:1340912 KIAA1530 -0.63 -8.68 -0.43 1.82e-16 Obesity-related traits; CRC cis rs8062405 0.540 rs480400 chr16:28574615 A/G cg05139728 chr16:28306816 SBK1 -0.32 -5.74 -0.3 2.21e-8 Cognitive ability (multi-trait analysis);Cognitive ability; CRC cis rs7945705 0.967 rs7123861 chr11:8892323 G/A cg00186954 chr11:8933980 ST5;C11orf17 0.46 7.23 0.37 3.49e-12 Hemoglobin concentration; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg20859525 chr6:80714300 TTK 0.44 6.27 0.33 1.12e-9 Response to antipsychotic treatment; CRC cis rs13108904 0.901 rs12509700 chr4:1296321 A/G cg19318889 chr4:1322082 MAEA 0.42 6.43 0.33 4.45e-10 Obesity-related traits; CRC cis rs12048904 1.000 rs12048904 chr1:101331536 C/T cg16556008 chr1:101360663 SLC30A7;EXTL2 -0.59 -8.7 -0.43 1.59e-16 Multiple sclerosis; CRC cis rs3749237 0.595 rs1050088 chr3:49570882 C/T cg07636037 chr3:49044803 WDR6 -0.55 -7.96 -0.4 2.88e-14 Resting heart rate; CRC cis rs9914988 0.943 rs9915673 chr17:27132893 G/C cg12682573 chr17:27188876 MIR451;MIR144 0.58 7.99 0.4 2.37e-14 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs7249142 0.562 rs1050544 chr19:19287901 A/G cg26504305 chr19:19281019 LOC729991-MEF2B;MEF2B -0.43 -8.68 -0.43 1.83e-16 IgG glycosylation; CRC cis rs2153535 0.580 rs2184582 chr6:8447793 G/A cg07606381 chr6:8435919 SLC35B3 0.68 10.85 0.51 1.22e-23 Motion sickness; CRC cis rs9649213 0.593 rs1859482 chr7:97983774 C/T cg24562669 chr7:97807699 LMTK2 0.44 7.32 0.37 1.97e-12 Prostate cancer (SNP x SNP interaction); CRC cis rs9914988 0.943 rs7217547 chr17:27106872 C/G cg12682573 chr17:27188876 MIR451;MIR144 0.6 8.88 0.44 4.38e-17 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs992157 0.560 rs12992937 chr2:219087072 A/T cg04731861 chr2:219085781 ARPC2 0.37 7.99 0.4 2.37e-14 Colorectal cancer; CRC cis rs2204008 0.605 rs4608149 chr12:38132057 G/C cg13010199 chr12:38710504 ALG10B 0.45 5.74 0.3 2.1e-8 Bladder cancer; CRC trans rs875971 0.660 rs2191268 chr7:66110224 C/T cg01626995 chr9:139526017 NA -0.43 -6.81 -0.35 4.67e-11 Aortic root size; CRC cis rs7216064 0.532 rs3890640 chr17:66053028 C/T cg12091567 chr17:66097778 LOC651250 0.91 13.53 0.6 1.84e-33 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg27274463 chr12:110338238 TCHP 0.39 6.45 0.34 3.88e-10 Obesity-related traits; CRC cis rs9768139 0.683 rs4909178 chr7:158117752 T/A cg24154853 chr7:158122151 PTPRN2 0.61 9.89 0.48 2.36e-20 Calcium levels; CRC cis rs798554 0.679 rs2533868 chr7:2886559 G/A cg04166393 chr7:2884313 GNA12 0.55 7.71 0.39 1.49e-13 Height; CRC cis rs77861329 1.000 rs123681 chr3:52209320 A/G cg08692210 chr3:52188851 WDR51A 0.83 7.81 0.4 7.57e-14 Macrophage inflammatory protein 1b levels; CRC cis rs6860806 1.000 rs6860806 chr5:131640536 C/T cg12564285 chr5:131593104 PDLIM4 -0.39 -7.48 -0.38 6.88e-13 Breast cancer; CRC cis rs6951245 0.872 rs77434655 chr7:1098405 G/A cg26224354 chr7:1096374 C7orf50;GPR146 -0.93 -12.05 -0.55 5.9e-28 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs807029 0.533 rs3740486 chr10:102750623 T/C cg04662943 chr10:102668895 NA 0.59 7.25 0.37 3.07e-12 Ejection fraction in Tripanosoma cruzi seropositivity; CRC cis rs7113874 0.569 rs11041985 chr11:8582684 A/G cg02811074 chr11:8615871 STK33 -0.34 -5.87 -0.31 1.05e-8 Body mass index in physically active individuals;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs45544231 0.569 rs9302556 chr16:52543645 C/A cg09051775 chr16:52580266 TOX3 -0.38 -6.16 -0.32 2.15e-9 Restless legs syndrome; CRC cis rs9522267 0.535 rs9522296 chr13:112234340 C/T cg10483660 chr13:112241077 NA 0.47 8.89 0.44 4.16e-17 Hepatitis; CRC cis rs752092 1.000 rs7182945 chr15:101784223 C/T cg19997662 chr15:101784653 CHSY1 -0.63 -10.14 -0.49 3.25e-21 Corneal structure; CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg04639396 chr7:27190539 NA -0.5 -6.06 -0.32 3.64e-9 Diisocyanate-induced asthma; CRC cis rs10760158 0.769 rs10985200 chr9:124043867 C/T cg14417974 chr9:124058376 GSN -0.33 -5.63 -0.3 3.83e-8 Pulse pressure; CRC cis rs11098699 0.821 rs904712 chr4:124225337 T/C cg09941581 chr4:124220074 SPATA5 0.43 6.33 0.33 7.98e-10 Mosquito bite size; CRC cis rs40363 0.672 rs1617722 chr16:3520806 C/T cg00484396 chr16:3507460 NAT15 -0.54 -7.89 -0.4 4.67e-14 Tuberculosis; CRC cis rs7412746 0.658 rs4970988 chr1:150950062 A/G cg10589385 chr1:150898437 SETDB1 -0.3 -6.2 -0.32 1.65e-9 Melanoma; CRC cis rs6570726 0.791 rs400329 chr6:145879442 A/T cg05347473 chr6:146136440 FBXO30 0.4 6.1 0.32 2.95e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs57221529 0.545 rs55955015 chr5:575182 A/G cg14541582 chr5:601475 NA -0.34 -6.64 -0.34 1.33e-10 Lung disease severity in cystic fibrosis; CRC cis rs344364 0.511 rs1657132 chr16:1949924 C/T cg00046913 chr16:1877150 HAGH;FAHD1 -0.56 -5.71 -0.3 2.58e-8 Glomerular filtration rate in chronic kidney disease; CRC cis rs7512552 0.809 rs1694377 chr1:150293153 A/G cg15654264 chr1:150340011 RPRD2 0.55 7.66 0.39 2.05e-13 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); CRC cis rs1005277 0.540 rs116205409 chr10:38478970 G/A cg00409905 chr10:38381863 ZNF37A -0.65 -10.65 -0.51 5.95e-23 Extrinsic epigenetic age acceleration; CRC cis rs1799949 1.000 rs8176083 chr17:41275151 G/C cg23758822 chr17:41437982 NA 0.8 13.45 0.6 3.64e-33 Menopause (age at onset); CRC cis rs2204008 0.775 rs12099736 chr12:38344111 C/G cg13010199 chr12:38710504 ALG10B 0.47 6.28 0.33 1.09e-9 Bladder cancer; CRC cis rs9372498 0.536 rs9481825 chr6:118876092 C/T cg22561889 chr6:118971681 C6orf204 0.51 6.83 0.35 4.04e-11 Diastolic blood pressure; CRC trans rs7647973 0.710 rs11130207 chr3:49611666 T/G cg21665057 chr3:196295764 WDR53;FBXO45 -0.67 -6.94 -0.36 2.13e-11 Menarche (age at onset); CRC cis rs754466 1.000 rs2278218 chr10:79680399 G/A cg17075019 chr10:79541650 NA -0.74 -10.25 -0.49 1.45e-21 Liver enzyme levels (gamma-glutamyl transferase); CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg04977983 chr14:39572202 SEC23A -0.4 -6.25 -0.33 1.27e-9 Myopia (pathological); CRC cis rs7917772 0.582 rs3936017 chr10:104354424 T/C cg11453585 chr10:104263688 ACTR1A;SUFU 0.82 15.29 0.64 3.12e-40 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC cis rs17095355 1.000 rs17126931 chr10:111754633 T/C cg00817464 chr10:111662876 XPNPEP1 -0.52 -5.89 -0.31 9.74e-9 Biliary atresia; CRC cis rs939584 1.000 rs10192350 chr2:652607 T/C cg03610516 chr2:642275 NA -0.43 -5.93 -0.31 7.78e-9 Body mass index; CRC cis rs13108904 0.870 rs11721789 chr4:1254414 C/A cg21620606 chr4:1342894 KIAA1530 0.4 6.94 0.36 2.06e-11 Obesity-related traits; CRC cis rs7208859 0.673 rs9889968 chr17:29220128 C/A cg01831904 chr17:28903510 LRRC37B2 -0.56 -5.83 -0.31 1.35e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg21638063 chr5:107717975 FBXL17 0.4 6.12 0.32 2.71e-9 Liver disease severity in Alagille syndrome; CRC cis rs4481887 1.000 rs4360553 chr1:248467092 A/G cg00666640 chr1:248458726 OR2T12 0.51 9.12 0.45 7.72e-18 Common traits (Other); CRC cis rs853679 0.699 rs9468318 chr6:28209531 T/A cg15786705 chr6:28176104 NA 0.62 6.67 0.34 1.11e-10 Depression; CRC cis rs10504229 1.000 rs66477954 chr8:58187810 C/T cg01721255 chr8:58191610 C8orf71 0.49 6.17 0.32 2e-9 Developmental language disorder (linguistic errors); CRC cis rs3015497 0.616 rs6572678 chr14:51090115 T/G cg09863266 chr14:51125203 SAV1 -0.3 -5.76 -0.3 1.93e-8 Mean platelet volume; CRC cis rs6754311 0.773 rs666407 chr2:136640233 A/G cg25344623 chr2:136566232 LCT -0.32 -5.85 -0.31 1.17e-8 Mosquito bite size; CRC cis rs1577917 0.958 rs12190603 chr6:86475718 C/A cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.52 -7.11 -0.36 7.42e-12 Response to antipsychotic treatment; CRC cis rs1707322 0.963 rs6666763 chr1:46436451 C/A cg03146154 chr1:46216737 IPP 0.51 7.06 0.36 1.01e-11 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs7591163 1.000 rs4487084 chr2:228713179 G/A cg01216370 chr2:228736459 WDR69 -0.45 -5.7 -0.3 2.68e-8 Blood pressure; CRC trans rs11581859 0.950 rs55842403 chr1:99358542 C/T cg12183875 chr3:169587454 LRRC31 0.25 5.99 0.31 5.39e-9 Response to cognitive-behavioural therapy in anxiety disorder; CRC trans rs2228479 1.000 rs117406136 chr16:89974605 C/T cg24644049 chr4:85504048 CDS1 0.88 7.8 0.4 8.53e-14 Skin colour saturation; CRC cis rs7809950 1.000 rs2395883 chr7:107089670 T/C cg23024343 chr7:107201750 COG5 -0.6 -8.63 -0.43 2.63e-16 Coronary artery disease; CRC cis rs3820068 0.581 rs16851848 chr1:15927698 G/A cg27534772 chr1:16042836 PLEKHM2 0.55 10.85 0.51 1.21e-23 Systolic blood pressure; CRC cis rs9322193 0.962 rs9505974 chr6:150100430 C/T cg07701084 chr6:150067640 NUP43 0.47 6.72 0.35 8.19e-11 Lung cancer; CRC cis rs6951245 0.529 rs10262070 chr7:1141738 C/T cg22907277 chr7:1156413 C7orf50 0.82 10.57 0.5 1.09e-22 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs12745968 0.589 rs3903212 chr1:92984055 A/G cg17283838 chr1:93427260 FAM69A -0.45 -6.19 -0.32 1.74e-9 Bipolar disorder and schizophrenia; CRC cis rs5769765 0.862 rs7410537 chr22:50317330 G/A cg02269571 chr22:50332266 NA -0.61 -7.52 -0.38 5.19e-13 Schizophrenia; CRC trans rs10506458 1.000 rs17763435 chr12:63416511 A/G cg22491629 chr6:157744540 C6orf35 0.68 7.96 0.4 2.79e-14 Hemostatic factors and hematological phenotypes; CRC cis rs79349575 0.783 rs4793996 chr17:47019597 T/C cg22482690 chr17:47019901 SNF8 0.48 8.01 0.4 2.01e-14 Type 2 diabetes; CRC cis rs6976053 0.935 rs4727469 chr7:100509163 C/T cg10426581 chr7:100472382 SRRT 0.38 5.79 0.3 1.62e-8 Plasminogen activator inhibitor type 1 levels (PAI-1); CRC cis rs4731207 0.536 rs34630567 chr7:124630663 G/A cg23710748 chr7:124431027 NA -0.39 -6.34 -0.33 7.73e-10 Cutaneous malignant melanoma; CRC cis rs7618915 0.547 rs12496634 chr3:52709259 A/C cg10802521 chr3:52805072 NEK4 -0.59 -9.02 -0.45 1.55e-17 Bipolar disorder; CRC cis rs3736485 0.966 rs6493510 chr15:51900651 T/G cg08986416 chr15:51914746 DMXL2 -0.46 -6.6 -0.34 1.67e-10 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg04073608 chr11:65268100 MALAT1 0.45 6.05 0.32 3.86e-9 Thyroid stimulating hormone; CRC cis rs172166 0.694 rs2791332 chr6:28108788 C/T cg10876282 chr6:28092338 ZSCAN16 0.48 6.38 0.33 5.96e-10 Cardiac Troponin-T levels; CRC cis rs798766 1.000 rs11729657 chr4:1737585 T/C cg05874882 chr4:1763078 NA -0.36 -6.7 -0.35 8.92e-11 Bladder cancer;Urinary bladder cancer; CRC trans rs1656966 1.000 rs1656966 chr3:186466252 C/T cg06194421 chr17:33570128 SLFN5 0.42 6.42 0.33 4.8e-10 Myopia (pathological); CRC cis rs7119 0.931 rs11630540 chr15:77833625 G/A cg27398640 chr15:77910606 LINGO1 -0.4 -7.11 -0.36 7.26e-12 Type 2 diabetes; CRC cis rs4653767 1.000 rs4653767 chr1:226916078 T/C cg05049329 chr1:226924846 ITPKB 0.39 8.81 0.44 7.52e-17 Parkinson's disease; CRC cis rs243505 0.691 rs243480 chr7:148452905 G/T cg09806900 chr7:148480153 CUL1 -0.6 -7.73 -0.39 1.34e-13 Inflammatory bowel disease;Crohn's disease; CRC cis rs7666738 0.830 rs10012271 chr4:99065154 A/C cg17366294 chr4:99064904 C4orf37 0.44 7.38 0.38 1.32e-12 Colonoscopy-negative controls vs population controls; CRC cis rs6860806 0.507 rs183898 chr5:131716902 C/G cg12564285 chr5:131593104 PDLIM4 -0.45 -7.62 -0.39 2.68e-13 Breast cancer; CRC trans rs6472235 0.837 rs4317552 chr8:66914293 G/T cg07884673 chr3:53033167 SFMBT1 -0.46 -6.34 -0.33 7.48e-10 Myopia (pathological);Plateletcrit; CRC trans rs17270561 1.000 rs12200962 chr6:25828986 T/C cg14063357 chr9:79793314 VPS13A;LOC100286938 0.6 6.19 0.32 1.83e-9 Iron status biomarkers; CRC cis rs2952156 0.876 rs2313171 chr17:37833842 T/C cg07936489 chr17:37558343 FBXL20 -0.4 -5.8 -0.3 1.53e-8 Asthma; CRC cis rs6459788 0.720 rs6965466 chr7:157250749 G/T cg06271696 chr7:157225062 NA -0.56 -9.52 -0.46 3.98e-19 Epstein-Barr virus copy number in lymphoblastoid cell lines; CRC cis rs12024301 0.557 rs77398368 chr1:183645845 G/A cg11505048 chr1:183622726 RGL1;APOBEC4 0.73 6.43 0.33 4.43e-10 Peripheral arterial disease (traffic-related air pollution interaction); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg23052081 chr20:50808205 ZFP64 0.53 7.68 0.39 1.81e-13 Response to antipsychotic treatment; CRC cis rs6502050 0.835 rs8080625 chr17:80115447 G/A cg22110888 chr17:80059540 CCDC57 0.4 6.48 0.34 3.37e-10 Life satisfaction; CRC cis rs6089584 0.850 rs881993 chr20:60623862 A/G cg18761221 chr20:60518478 NA 0.47 7.52 0.38 5.36e-13 Body mass index; CRC cis rs798554 0.679 rs1639066 chr7:2892972 A/G cg13628971 chr7:2884303 GNA12 0.6 8.34 0.42 2.01e-15 Height; CRC cis rs2836974 0.966 rs7283420 chr21:40666865 T/C cg11890956 chr21:40555474 PSMG1 0.99 15.5 0.65 4.7e-41 Cognitive function; CRC cis rs6502050 0.835 rs8067875 chr17:80092778 C/T cg25804541 chr17:80189381 SLC16A3 -0.3 -5.8 -0.3 1.58e-8 Life satisfaction; CRC trans rs1455244 0.700 rs7229302 chr18:11508904 G/T cg12975295 chr9:86571409 C9orf64 0.43 6.5 0.34 3.04e-10 Schizophrenia; CRC cis rs12922317 0.538 rs442234 chr16:12072161 A/G cg09319797 chr16:12061715 TNFRSF17 0.35 5.92 0.31 7.98e-9 Schizophrenia; CRC cis rs4478858 0.735 rs7523509 chr1:31788329 A/G cg07478791 chr1:31886160 SERINC2 -0.41 -5.68 -0.3 2.89e-8 Alcohol dependence; CRC cis rs34375054 0.660 rs12578446 chr12:125605887 A/G cg02766259 chr12:125626809 AACS -0.43 -7.22 -0.37 3.54e-12 Post bronchodilator FEV1/FVC ratio; CRC cis rs9322193 0.923 rs9688350 chr6:150052113 A/T cg00933542 chr6:150070202 PCMT1 0.31 6.19 0.32 1.8e-9 Lung cancer; CRC cis rs2692947 0.832 rs2579550 chr2:96741944 G/A cg23100626 chr2:96804247 ASTL 0.28 7.41 0.38 1.11e-12 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; CRC cis rs11190604 1.000 rs7099913 chr10:102314777 T/C cg16342193 chr10:102329863 NA -0.33 -5.71 -0.3 2.59e-8 Palmitoleic acid (16:1n-7) levels; CRC trans rs1005277 0.579 rs2505241 chr10:38442421 T/C cg17830980 chr10:43048298 ZNF37B -0.59 -9.9 -0.48 2.08e-20 Extrinsic epigenetic age acceleration; CRC cis rs951366 0.585 rs72750964 chr1:205675240 C/T cg26354017 chr1:205819088 PM20D1 0.71 10.29 0.49 1.04e-21 Menarche (age at onset); CRC trans rs2898857 0.524 rs2119931 chr17:47429834 A/G cg11430096 chr6:110968061 CDK19 -0.48 -7.48 -0.38 6.89e-13 Cancer; CRC cis rs6860806 0.507 rs2631372 chr5:131703578 C/G cg11843238 chr5:131593191 PDLIM4 0.45 7.63 0.39 2.59e-13 Breast cancer; CRC cis rs9311474 0.508 rs7625743 chr3:52606366 C/G cg18404041 chr3:52824283 ITIH1 -0.4 -8.45 -0.42 9.79e-16 Electroencephalogram traits; CRC cis rs3750082 0.817 rs3750078 chr7:32969489 G/A cg05721444 chr7:32995514 FKBP9 -0.51 -7.75 -0.39 1.14e-13 Glomerular filtration rate (creatinine); CRC cis rs875971 1.000 rs778710 chr7:65854834 T/C cg00343986 chr7:65444356 GUSB 0.43 6.3 0.33 9.66e-10 Aortic root size; CRC cis rs4742903 0.967 rs2417485 chr9:106867106 A/C cg21169611 chr9:106856078 SMC2 0.4 5.67 0.3 3.12e-8 High-grade serous ovarian cancer;Breast cancer; CRC cis rs11212617 0.902 rs599406 chr11:108118234 T/A cg12106634 chr11:108092400 ATM;NPAT 0.43 6.26 0.33 1.22e-9 Response to metformin in type 2 diabetes (glycemic); CRC cis rs2075371 0.865 rs2544172 chr7:133931338 T/C cg11752832 chr7:134001865 SLC35B4 0.42 6.36 0.33 6.58e-10 Mean platelet volume; CRC cis rs6582630 0.555 rs35186318 chr12:38295822 C/T cg13010199 chr12:38710504 ALG10B -0.41 -5.8 -0.3 1.53e-8 Drug-induced liver injury (flucloxacillin); CRC cis rs7605827 0.897 rs13014906 chr2:15614404 T/C cg19274914 chr2:15703543 NA 0.39 5.94 0.31 7.43e-9 Educational attainment (years of education); CRC cis rs826838 1.000 rs10506122 chr12:38699232 A/G cg13010199 chr12:38710504 ALG10B 0.5 6.67 0.35 1.08e-10 Heart rate; CRC cis rs1200821 0.535 rs1208783 chr10:37767467 A/G cg25427524 chr10:38739819 LOC399744 -0.59 -8.97 -0.44 2.31e-17 Hemostatic factors and hematological phenotypes; CRC cis rs12142240 0.698 rs17413701 chr1:46818452 A/G cg00530320 chr1:46809349 NSUN4 0.58 7.93 0.4 3.43e-14 Menopause (age at onset); CRC cis rs561341 0.663 rs72821936 chr17:30224068 C/G cg00745463 chr17:30367425 LRRC37B -0.44 -5.88 -0.31 9.89e-9 Hip circumference adjusted for BMI; CRC cis rs929354 0.772 rs6459741 chr7:157014553 G/T cg05182265 chr7:156933206 UBE3C -0.77 -14.67 -0.63 7.87e-38 Body mass index; CRC cis rs7771547 0.519 rs28371845 chr6:36377709 C/T cg07856975 chr6:36356162 ETV7 0.47 5.87 0.31 1.06e-8 Platelet distribution width; CRC cis rs747650 0.892 rs7111764 chr11:47233209 G/A cg03339077 chr11:47165057 C11orf49 0.45 6.37 0.33 6.55e-10 Acne (severe); CRC cis rs6743376 0.556 rs1530553 chr2:113818171 G/A cg24553058 chr2:113831203 IL1F10 0.43 6.96 0.36 1.81e-11 Inflammatory biomarkers; CRC cis rs6783573 0.711 rs3806701 chr3:46617337 G/A cg21489266 chr3:46619131 LRRC2;TDGF1 -0.43 -6.11 -0.32 2.86e-9 Cerebrospinal fluid biomarker levels; CRC cis rs6540559 0.673 rs11805830 chr1:209984969 C/T cg22029157 chr1:209979665 IRF6 0.72 9.54 0.47 3.38e-19 Cleft lip with or without cleft palate; CRC cis rs2014572 0.967 rs10411941 chr19:57762886 C/T cg12963866 chr19:57752005 ZNF805 -0.41 -6.09 -0.32 3.15e-9 Hyperactive-impulsive symptoms; CRC cis rs11098499 0.645 rs78422072 chr4:120281042 C/T cg09307838 chr4:120376055 NA 0.68 10.32 0.49 8.06e-22 Corneal astigmatism; CRC cis rs12926788 0.546 rs200537 chr16:24747787 G/C cg02428538 chr16:24856791 SLC5A11 0.55 6.6 0.34 1.68e-10 Ejection fraction in Tripanosoma cruzi seropositivity; CRC cis rs1059312 0.966 rs12370194 chr12:129277250 A/T cg09035930 chr12:129282057 SLC15A4 0.55 9.2 0.45 4.2e-18 Systemic lupus erythematosus; CRC cis rs7829975 0.806 rs2428 chr8:8641145 C/T cg14979609 chr8:8086686 FLJ10661 -0.35 -5.89 -0.31 9.71e-9 Mood instability; CRC cis rs1799949 1.000 rs8176109 chr17:41265776 A/G cg25072359 chr17:41440525 NA 0.46 7.02 0.36 1.29e-11 Menopause (age at onset); CRC trans rs1997103 0.906 rs4618644 chr7:55402037 T/G cg20935933 chr6:143382018 AIG1 0.52 6.72 0.35 7.8e-11 QRS interval (sulfonylurea treatment interaction); CRC cis rs34779708 0.931 rs11592404 chr10:35273476 G/A cg03585969 chr10:35415529 CREM 0.66 8.76 0.43 1.09e-16 Inflammatory bowel disease;Crohn's disease; CRC cis rs2880765 0.835 rs11074276 chr15:86030363 C/A cg17133734 chr15:86042851 AKAP13 0.43 6.73 0.35 7.69e-11 Coronary artery disease; CRC cis rs6502050 0.842 rs7211808 chr17:80071244 T/C cg22110888 chr17:80059540 CCDC57 -0.41 -6.36 -0.33 6.72e-10 Life satisfaction; CRC cis rs7487075 0.786 rs7965629 chr12:46675066 G/C cg22049899 chr12:47219821 SLC38A4 0.32 5.77 0.3 1.84e-8 Itch intensity from mosquito bite; CRC cis rs8141529 0.732 rs2239815 chr22:29192670 C/T cg02153584 chr22:29168773 CCDC117 -0.52 -7.91 -0.4 3.94e-14 Lymphocyte counts; CRC cis rs10504229 0.683 rs55660024 chr8:58128943 G/A cg02725872 chr8:58115012 NA -0.64 -11.55 -0.54 3.85e-26 Developmental language disorder (linguistic errors); CRC cis rs539514 0.690 rs2328953 chr13:76317459 T/G cg04757411 chr13:76259545 LMO7 -0.34 -5.7 -0.3 2.67e-8 Type 1 diabetes; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg22776125 chr6:167041314 RPS6KA2 0.51 6.69 0.35 9.75e-11 Thyroid stimulating hormone; CRC cis rs7772486 0.875 rs854145 chr6:146349650 C/T cg05347473 chr6:146136440 FBXO30 0.36 5.62 0.3 4.02e-8 Lobe attachment (rater-scored or self-reported); CRC cis rs2737618 0.674 rs2737683 chr1:200092448 G/A cg21825944 chr1:200113062 NR5A2 -0.5 -7.36 -0.38 1.45e-12 Uric acid levels; CRC cis rs1401999 1.000 rs6767013 chr3:183680102 G/A cg05044414 chr3:183734942 ABCC5 0.48 8.29 0.42 3.02e-15 Anterior chamber depth; CRC cis rs9733 0.596 rs11803569 chr1:150664077 C/T cg17724175 chr1:150552817 MCL1 0.58 9.4 0.46 9.25e-19 Tonsillectomy; CRC cis rs4237845 0.788 rs6581157 chr12:58288793 C/T cg00677455 chr12:58241039 CTDSP2 0.68 9.58 0.47 2.55e-19 Intelligence (multi-trait analysis); CRC cis rs10504229 0.512 rs117968470 chr8:58014651 C/G cg20607798 chr8:58055168 NA 0.5 5.78 0.3 1.75e-8 Developmental language disorder (linguistic errors); CRC cis rs6500395 1.000 rs12599028 chr16:48713082 C/A cg04672837 chr16:48644449 N4BP1 -0.45 -6.63 -0.34 1.38e-10 Response to tocilizumab in rheumatoid arthritis; CRC cis rs875971 0.545 rs2173571 chr7:65770379 G/A cg18876405 chr7:65276391 NA 0.46 6.44 0.33 4.29e-10 Aortic root size; CRC cis rs12983728 0.732 rs34003091 chr19:58662254 T/C cg06882758 chr19:58662330 ZNF329 0.77 8.08 0.41 1.24e-14 Cholesterol, total; CRC trans rs11098499 0.754 rs17595608 chr4:120250506 C/T cg25214090 chr10:38739885 LOC399744 0.53 8.32 0.42 2.41e-15 Corneal astigmatism; CRC cis rs17711722 0.727 rs35850374 chr7:65357776 A/G cg00343986 chr7:65444356 GUSB 0.56 8.47 0.42 8.43e-16 Calcium levels; CRC cis rs17092148 0.945 rs17092080 chr20:33335657 A/G cg08999081 chr20:33150536 PIGU 0.46 5.73 0.3 2.24e-8 Neuroticism; CRC cis rs7474896 0.515 rs2749582 chr10:38275284 A/G cg25427524 chr10:38739819 LOC399744 0.59 7.32 0.37 1.94e-12 Obesity (extreme); CRC cis rs9326248 0.861 rs1871757 chr11:117030581 A/T cg11861562 chr11:117069780 TAGLN 0.32 6.13 0.32 2.5e-9 Blood protein levels; CRC cis rs736408 0.509 rs1108842 chr3:52720080 A/C cg15147215 chr3:52552868 STAB1 -0.71 -13.09 -0.59 8.66e-32 Bipolar disorder; CRC cis rs7927592 0.871 rs871212 chr11:68348695 T/A cg16797656 chr11:68205561 LRP5 0.36 5.81 0.31 1.47e-8 Total body bone mineral density; CRC cis rs877282 0.898 rs11253344 chr10:765162 C/T cg17470449 chr10:769945 NA 0.66 8.48 0.42 7.57e-16 Uric acid levels; CRC cis rs7959452 0.590 rs28778648 chr12:69771911 C/A cg22834771 chr12:69754056 YEATS4 -0.53 -7.93 -0.4 3.55e-14 Blood protein levels; CRC cis rs6952808 0.609 rs4721185 chr7:1951109 T/C cg04267008 chr7:1944627 MAD1L1 -0.63 -9.65 -0.47 1.46e-19 Bipolar disorder and schizophrenia; CRC cis rs1348850 0.914 rs10497503 chr2:178371739 G/T cg02961200 chr2:178257176 LOC100130691;AGPS 0.61 8.86 0.44 4.97e-17 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs10504229 0.683 rs16921831 chr8:58111142 G/A cg04204079 chr8:58130323 NA -0.46 -5.84 -0.31 1.22e-8 Developmental language disorder (linguistic errors); CRC cis rs7829975 0.711 rs12682352 chr8:8646246 A/G cg06636001 chr8:8085503 FLJ10661 0.58 9.63 0.47 1.68e-19 Mood instability; CRC cis rs2180341 0.920 rs4472373 chr6:127705983 G/A cg24812749 chr6:127587940 RNF146 0.96 13.35 0.59 8.56e-33 Breast cancer; CRC cis rs1008375 1.000 rs10011865 chr4:17645710 G/A cg04450456 chr4:17643702 FAM184B 0.41 6.72 0.35 8.23e-11 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs9311474 0.597 rs6778735 chr3:52565100 T/C cg17372223 chr3:52568218 NT5DC2 0.37 5.7 0.3 2.7e-8 Electroencephalogram traits; CRC trans rs6951245 0.872 rs113119264 chr7:1080564 G/A cg13565492 chr6:43139072 SRF -0.71 -7.27 -0.37 2.61e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs883565 0.606 rs6763607 chr3:39091596 C/G cg01426195 chr3:39028469 NA -0.47 -8.01 -0.4 2e-14 Handedness; CRC cis rs3087591 0.659 rs2214538 chr17:29636570 C/T cg24425628 chr17:29625626 OMG;NF1 0.73 13.3 0.59 1.33e-32 Hip circumference; CRC cis rs8141529 0.584 rs58004020 chr22:29257050 A/T cg02153584 chr22:29168773 CCDC117 0.5 7.31 0.37 2.05e-12 Lymphocyte counts; CRC cis rs6951245 1.000 rs884977 chr7:1066410 T/C cg20603222 chr7:1096387 C7orf50;GPR146 -0.53 -7.1 -0.36 7.53e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs4478858 0.684 rs10798838 chr1:31719450 G/A cg00250761 chr1:31883323 NA -0.43 -8.49 -0.42 7.13e-16 Alcohol dependence; CRC cis rs477895 0.713 rs7952318 chr11:63961242 G/A cg01518246 chr11:63870912 FLRT1;MACROD1 0.44 6.09 0.32 3.17e-9 Mean platelet volume; CRC cis rs832540 0.695 rs702686 chr5:56201350 A/G cg20203395 chr5:56204925 C5orf35 -0.55 -7.46 -0.38 7.64e-13 Coronary artery disease; CRC cis rs736408 0.562 rs12497998 chr3:52793602 C/T cg10802521 chr3:52805072 NEK4 -0.58 -8.95 -0.44 2.62e-17 Bipolar disorder; CRC cis rs7666738 0.830 rs13119995 chr4:99026790 T/C cg05340658 chr4:99064831 C4orf37 0.61 9.37 0.46 1.21e-18 Colonoscopy-negative controls vs population controls; CRC trans rs2303319 0.504 rs62189055 chr2:162625749 C/A cg22988483 chr14:93581567 ITPK1 -0.66 -6.05 -0.32 4.02e-9 Cognitive function; CRC cis rs6840360 0.967 rs10776524 chr4:152602585 G/A cg09659197 chr4:152720779 NA 0.52 11.13 0.52 1.23e-24 Intelligence (multi-trait analysis); CRC cis rs7827545 1.000 rs4909911 chr8:135565255 G/A cg13086574 chr8:135490821 ZFAT -0.36 -6.08 -0.32 3.4e-9 Hypertension (SNP x SNP interaction); CRC cis rs6460942 0.915 rs7809263 chr7:12450589 C/G cg06484146 chr7:12443880 VWDE -0.73 -8.07 -0.41 1.33e-14 Coronary artery disease; CRC cis rs1862618 0.853 rs1559282 chr5:56099375 T/A cg20203395 chr5:56204925 C5orf35 -0.59 -6.9 -0.36 2.63e-11 Initial pursuit acceleration; CRC cis rs10504229 0.683 rs113492050 chr8:58130046 A/G cg04204079 chr8:58130323 NA -0.45 -5.78 -0.3 1.71e-8 Developmental language disorder (linguistic errors); CRC trans rs7618501 0.669 rs7634084 chr3:49949834 A/T cg21665057 chr3:196295764 WDR53;FBXO45 0.56 8.91 0.44 3.61e-17 Intelligence (multi-trait analysis); CRC cis rs6952808 0.823 rs58222895 chr7:1885064 G/A cg04267008 chr7:1944627 MAD1L1 -0.65 -9.52 -0.46 4e-19 Bipolar disorder and schizophrenia; CRC cis rs2242116 1.000 rs1138518 chr3:46944274 T/C cg27129171 chr3:47204927 SETD2 0.54 7.8 0.4 8.32e-14 Birth weight; CRC cis rs908922 0.676 rs6658925 chr1:152482801 C/T cg09873164 chr1:152488093 CRCT1 -0.35 -6.0 -0.31 5.22e-9 Hair morphology; CRC cis rs13118159 0.934 rs2878608 chr4:1354286 C/G cg19318889 chr4:1322082 MAEA 0.46 6.83 0.35 4.18e-11 Longevity; CRC cis rs40363 0.857 rs55989968 chr16:3530658 C/G cg22508957 chr16:3507546 NAT15 0.91 11.2 0.53 6.77e-25 Tuberculosis; CRC cis rs875971 0.520 rs12666485 chr7:65625122 T/C cg11764359 chr7:65958608 NA 0.47 5.9 0.31 9.21e-9 Aortic root size; CRC cis rs2985684 1.000 rs3007030 chr14:50086563 C/T cg10008539 chr14:50087325 RPL36AL;MGAT2 -0.47 -6.24 -0.33 1.37e-9 Carotid intima media thickness; CRC cis rs400736 0.535 rs4418631 chr1:8174197 A/G cg25007680 chr1:8021821 PARK7 0.48 6.59 0.34 1.77e-10 Response to antidepressants and depression; CRC cis rs875971 0.862 rs10224872 chr7:65759773 T/A cg18876405 chr7:65276391 NA -0.5 -8.31 -0.42 2.49e-15 Aortic root size; CRC cis rs62229266 0.839 rs11702763 chr21:37470704 A/G cg12218747 chr21:37451666 NA -0.38 -6.3 -0.33 9.37e-10 Mitral valve prolapse; CRC cis rs7932354 0.537 rs2290884 chr11:46890388 C/G cg19486271 chr11:47235900 DDB2 -0.41 -6.39 -0.33 5.67e-10 Bone mineral density (hip);Bone mineral density; CRC cis rs1580019 0.563 rs13225132 chr7:32800975 A/G cg06627557 chr7:32535165 LSM5;AVL9 0.94 16.26 0.67 4.86e-44 Cognitive ability; CRC cis rs2227564 0.649 rs2242258 chr10:75607168 T/C cg00564723 chr10:75632066 CAMK2G 0.36 8.63 0.43 2.72e-16 Crohn's disease;Inflammatory bowel disease; CRC cis rs208520 0.874 rs208491 chr6:66928459 C/G cg07460842 chr6:66804631 NA -0.95 -12.37 -0.56 4.11e-29 Exhaled nitric oxide output; CRC cis rs748404 0.560 rs572837 chr15:43823813 A/G cg02155558 chr15:43621948 ADAL;LCMT2 0.51 7.31 0.37 2.05e-12 Lung cancer; CRC cis rs4780401 0.933 rs1592572 chr16:11810382 T/C cg01061890 chr16:11836724 TXNDC11 -0.42 -5.61 -0.3 4.4e-8 Rheumatoid arthritis; CRC cis rs644799 1.000 rs7749 chr11:95565789 G/A cg25478527 chr11:95522999 CEP57;FAM76B 0.53 7.97 0.4 2.71e-14 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs11148252 0.740 rs9536046 chr13:52955899 T/G cg00495681 chr13:53174319 NA 0.57 8.15 0.41 7.67e-15 Lewy body disease; CRC cis rs3750965 1.000 rs731974 chr11:68847156 C/T cg06818126 chr11:68850279 TPCN2 -0.52 -7.35 -0.38 1.58e-12 Hair color; CRC cis rs3087591 0.960 rs8067021 chr17:29555078 T/A cg24425628 chr17:29625626 OMG;NF1 -0.87 -16.83 -0.68 2.79e-46 Hip circumference; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg19683962 chr4:108852534 CYP2U1 0.37 6.16 0.32 2.08e-9 Liver disease severity in Alagille syndrome; CRC cis rs780096 0.526 rs1647266 chr2:27693485 T/C cg27432699 chr2:27873401 GPN1 -0.52 -7.96 -0.4 2.91e-14 Total body bone mineral density; CRC cis rs2228479 0.681 rs10153055 chr16:89965842 C/T cg04013166 chr16:89971882 TCF25 0.68 8.55 0.43 4.71e-16 Skin colour saturation; CRC trans rs2303319 0.504 rs12467279 chr2:162544744 A/G cg12500891 chr11:57225987 NA -0.68 -6.07 -0.32 3.55e-9 Cognitive function; CRC cis rs6456156 0.774 rs6908364 chr6:167527296 C/T cg05540913 chr6:167530185 CCR6 -0.38 -6.99 -0.36 1.54e-11 Primary biliary cholangitis; CRC cis rs875971 0.862 rs778734 chr7:65814849 C/G cg18252515 chr7:66147081 NA -0.4 -5.82 -0.31 1.4e-8 Aortic root size; CRC cis rs2153535 0.580 rs9505448 chr6:8459804 A/G cg21535247 chr6:8435926 SLC35B3 0.51 7.9 0.4 4.36e-14 Motion sickness; CRC cis rs10504229 0.593 rs12155520 chr8:58014318 C/T cg22535103 chr8:58192502 C8orf71 -0.64 -7.01 -0.36 1.34e-11 Developmental language disorder (linguistic errors); CRC cis rs17331151 0.573 rs79664140 chr3:52866936 A/G cg06204229 chr3:52865917 ITIH4 0.58 7.91 0.4 3.9e-14 Immune reponse to smallpox (secreted IL-2); CRC cis rs4555082 0.830 rs2255575 chr14:105727251 T/C cg13114125 chr14:105738426 BRF1 -0.79 -11.73 -0.54 8.56e-27 Mean platelet volume;Platelet distribution width; CRC cis rs7615952 0.576 rs66671308 chr3:125793526 T/G cg05084668 chr3:125655381 ALG1L -0.43 -6.18 -0.32 1.88e-9 Blood pressure (smoking interaction); CRC cis rs2836950 0.501 rs2056844 chr21:40670460 G/C cg11644478 chr21:40555479 PSMG1 -0.46 -6.83 -0.35 4e-11 Menarche (age at onset); CRC cis rs2303745 0.589 rs891018 chr19:17396761 C/T cg04248312 chr19:17393744 ANKLE1 0.93 13.93 0.61 5.22e-35 Systemic lupus erythematosus; CRC cis rs11148252 0.514 rs9526843 chr13:52730056 C/T cg00495681 chr13:53174319 NA 0.55 8.04 0.41 1.64e-14 Lewy body disease; CRC cis rs6570726 0.791 rs9373463 chr6:145894762 C/T cg05347473 chr6:146136440 FBXO30 0.38 5.85 0.31 1.18e-8 Lobe attachment (rater-scored or self-reported); CRC cis rs4862750 0.914 rs9995391 chr4:187873749 A/T cg10295955 chr4:187884368 NA 0.97 21.36 0.76 3.91e-64 Lobe attachment (rater-scored or self-reported); CRC trans rs208515 0.525 rs10944871 chr6:66690306 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.95 12.19 0.56 1.93e-28 Exhaled nitric oxide levels; CRC cis rs10504229 0.728 rs17216187 chr8:58158778 G/T cg22535103 chr8:58192502 C8orf71 -0.7 -8.43 -0.42 1.07e-15 Developmental language disorder (linguistic errors); CRC cis rs763121 0.819 rs5757237 chr22:39073835 G/C cg06022373 chr22:39101656 GTPBP1 0.79 12.29 0.56 7.65e-29 Menopause (age at onset); CRC cis rs561341 1.000 rs113676348 chr17:30244327 A/G cg00745463 chr17:30367425 LRRC37B -0.73 -8.21 -0.41 5.15e-15 Hip circumference adjusted for BMI; CRC cis rs9462846 0.919 rs12202901 chr6:42828550 A/T cg02353165 chr6:42928485 GNMT 0.45 5.92 0.31 8.1e-9 Blood protein levels; CRC cis rs13118159 0.550 rs13123016 chr4:1340889 T/C cg21620606 chr4:1342894 KIAA1530 0.37 5.69 0.3 2.75e-8 Longevity; CRC cis rs950169 0.922 rs11630507 chr15:85095725 A/G cg03959625 chr15:84868606 LOC388152 0.39 5.86 0.31 1.1e-8 Schizophrenia; CRC cis rs758324 0.947 rs6886188 chr5:131178252 C/T cg25547332 chr5:131281432 NA 0.39 5.68 0.3 2.93e-8 Alzheimer's disease in APOE e4- carriers; CRC trans rs728616 0.764 rs56196124 chr10:81902655 A/T cg18543242 chr14:23290393 SLC7A7 0.45 6.01 0.31 4.96e-9 Chronic obstructive pulmonary disease-related biomarkers; CRC trans rs7142881 0.662 rs12885598 chr14:32071665 G/A cg07250515 chr12:56618133 OBFC2B -0.39 -6.1 -0.32 3.01e-9 Response to iloperidone treatment (QT prolongation); CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg13995117 chr16:1402058 GNPTG;C16orf42 0.46 6.36 0.33 6.85e-10 Anxiety disorder; CRC cis rs911555 0.723 rs12894652 chr14:103926024 A/G cg12935359 chr14:103987150 CKB 0.55 8.82 0.44 6.79e-17 Intelligence (multi-trait analysis); CRC cis rs62432291 0.681 rs402388 chr6:159654994 A/C cg14500486 chr6:159655392 FNDC1 -0.76 -10.4 -0.5 4.17e-22 Joint mobility (Beighton score); CRC cis rs950027 0.620 rs1145080 chr15:45681338 C/T cg21132104 chr15:45694354 SPATA5L1 0.4 5.83 0.31 1.33e-8 Response to fenofibrate (adiponectin levels); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg19447636 chr7:126894250 NA 0.47 6.72 0.35 7.89e-11 Intelligence (multi-trait analysis); CRC cis rs477895 0.653 rs12797120 chr11:63906819 C/T cg18225595 chr11:63971243 STIP1 0.57 7.54 0.38 4.59e-13 Mean platelet volume; CRC cis rs9649213 0.574 rs9648908 chr7:97945236 C/T cg21770322 chr7:97807741 LMTK2 0.5 8.23 0.41 4.38e-15 Prostate cancer (SNP x SNP interaction); CRC cis rs62432291 0.681 rs404461 chr6:159640709 T/C cg14500486 chr6:159655392 FNDC1 0.75 10.13 0.49 3.54e-21 Joint mobility (Beighton score); CRC cis rs2842992 0.789 rs9364536 chr6:160225559 G/C cg16489826 chr6:160211363 TCP1;MRPL18 0.49 6.14 0.32 2.32e-9 Age-related macular degeneration (geographic atrophy); CRC cis rs3733585 0.806 rs7375599 chr4:9954918 C/T cg00071950 chr4:10020882 SLC2A9 0.64 11.98 0.55 1.05e-27 Cleft plate (environmental tobacco smoke interaction); CRC cis rs4664293 0.867 rs11681565 chr2:160616873 C/G cg08347373 chr2:160653686 CD302 -0.47 -7.43 -0.38 9.32e-13 Monocyte percentage of white cells; CRC cis rs3785574 0.962 rs8079161 chr17:61808561 C/G cg23090583 chr17:61904693 PSMC5;FTSJ3 0.64 9.4 0.46 9.6e-19 Height; CRC cis rs4713118 0.824 rs742046 chr6:27739254 A/G cg06470822 chr6:28175283 NA 0.77 10.5 0.5 1.99e-22 Parkinson's disease; CRC cis rs9467711 0.659 rs13216828 chr6:26373507 G/A cg16898833 chr6:26189333 HIST1H4D 0.75 6.55 0.34 2.26e-10 Autism spectrum disorder or schizophrenia; CRC cis rs9916302 0.851 rs677888 chr17:37461018 T/G cg03013999 chr17:37608204 MED1 -0.49 -7.1 -0.36 7.8e-12 Glomerular filtration rate (creatinine); CRC cis rs1003719 0.788 rs2835605 chr21:38490734 T/A cg10648535 chr21:38446584 PIGP;TTC3 0.53 7.44 0.38 8.95e-13 Eye color traits; CRC cis rs17155006 0.664 rs440938 chr7:107741092 C/G cg05962710 chr7:107745446 LAMB4 -0.43 -7.57 -0.39 3.74e-13 Pneumococcal bacteremia; CRC trans rs7267979 0.966 rs2257712 chr20:25264910 T/C cg17903999 chr18:56338584 MALT1 -0.41 -6.82 -0.35 4.4e-11 Liver enzyme levels (alkaline phosphatase); CRC cis rs3820068 0.603 rs6429753 chr1:15900537 A/G cg27534772 chr1:16042836 PLEKHM2 0.51 8.95 0.44 2.69e-17 Systolic blood pressure; CRC cis rs10504229 1.000 rs61998259 chr8:58192290 T/C cg22535103 chr8:58192502 C8orf71 -0.82 -12.27 -0.56 9.63e-29 Developmental language disorder (linguistic errors); CRC cis rs709400 0.663 rs62007681 chr14:103884651 G/A cg12935359 chr14:103987150 CKB -0.52 -8.02 -0.4 1.83e-14 Body mass index; CRC cis rs1046896 0.553 rs56775875 chr17:80831291 G/T cg16060761 chr17:80687452 NA -0.45 -5.8 -0.3 1.52e-8 Glycated hemoglobin levels; CRC cis rs6088590 0.931 rs6088624 chr20:33436852 T/A cg08999081 chr20:33150536 PIGU 0.5 8.23 0.41 4.35e-15 Coronary artery disease; CRC cis rs58688157 0.626 rs7941198 chr11:571681 A/G cg09218773 chr11:619014 MUPCDH -0.35 -5.65 -0.3 3.51e-8 Systemic lupus erythematosus; CRC cis rs10979 0.562 rs9399446 chr6:143874639 G/C cg25407410 chr6:143891975 LOC285740 -0.51 -7.22 -0.37 3.69e-12 Hypospadias; CRC cis rs7615952 0.599 rs2270986 chr3:125701099 T/C cg05084668 chr3:125655381 ALG1L -0.46 -6.55 -0.34 2.18e-10 Blood pressure (smoking interaction); CRC cis rs853679 0.517 rs4713150 chr6:28136212 G/A cg12172441 chr6:28176163 NA 0.63 7.42 0.38 1.02e-12 Depression; CRC cis rs1799949 0.536 rs4793227 chr17:41412250 A/C cg19454999 chr17:41278357 BRCA1;NBR2 0.4 6.1 0.32 3.01e-9 Menopause (age at onset); CRC cis rs7618915 0.547 rs62255371 chr3:52747321 A/G cg11645453 chr3:52864694 ITIH4 0.35 6.02 0.32 4.62e-9 Bipolar disorder; CRC cis rs270601 0.770 rs10463891 chr5:131597392 C/T cg18758796 chr5:131593413 PDLIM4 -0.5 -9.25 -0.45 2.94e-18 Acylcarnitine levels; CRC cis rs929354 0.772 rs1182438 chr7:157027438 G/A cg16102536 chr7:156981717 UBE3C -0.41 -6.91 -0.36 2.55e-11 Body mass index; CRC cis rs1005277 0.579 rs2472176 chr10:38382921 T/C cg25517755 chr10:38738941 LOC399744 -0.44 -6.42 -0.33 4.85e-10 Extrinsic epigenetic age acceleration; CRC cis rs826838 1.000 rs1719848 chr12:39085586 A/G cg13010199 chr12:38710504 ALG10B -0.4 -6.03 -0.32 4.35e-9 Heart rate; CRC cis rs12950390 0.853 rs8078052 chr17:45859434 A/G cg24803719 chr17:45855879 NA -0.31 -6.91 -0.36 2.47e-11 IgG glycosylation; CRC trans rs9291683 0.527 rs11727087 chr4:10096020 A/G cg26043149 chr18:55253948 FECH 0.55 8.29 0.42 2.92e-15 Bone mineral density; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg07886860 chr3:40566285 ZNF621 0.45 6.2 0.32 1.73e-9 Anxiety disorder; CRC cis rs9560113 1.000 rs2104790 chr13:112177412 C/T cg10483660 chr13:112241077 NA 0.36 5.82 0.31 1.39e-8 Menarche (age at onset); CRC cis rs7809950 0.817 rs3779495 chr7:107250260 G/A cg23024343 chr7:107201750 COG5 0.75 10.29 0.49 9.9e-22 Coronary artery disease; CRC cis rs1185460 0.967 rs1784460 chr11:118938371 A/T cg23280166 chr11:118938394 VPS11 -0.45 -6.71 -0.35 8.73e-11 Coronary artery disease; CRC cis rs7552404 0.924 rs1498317 chr1:76171984 A/C cg10523679 chr1:76189770 ACADM 0.93 14.1 0.61 1.23e-35 Blood metabolite levels;Acylcarnitine levels; CRC cis rs10193935 0.901 rs10179237 chr2:42515501 C/T cg27598129 chr2:42591480 NA -0.54 -6.7 -0.35 8.85e-11 Colonoscopy-negative controls vs population controls; CRC cis rs3096299 0.685 rs8050512 chr16:89552320 C/G cg08392591 chr16:89556376 ANKRD11 0.43 5.92 0.31 8.12e-9 Multiple myeloma (IgH translocation); CRC cis rs9942416 0.660 rs17563686 chr5:74984818 A/T cg19683494 chr5:74908142 NA 0.5 6.36 0.33 6.94e-10 Age-related disease endophenotypes; CRC cis rs2692947 0.673 rs2917662 chr2:96794957 G/A cg23100626 chr2:96804247 ASTL 0.32 8.74 0.43 1.24e-16 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; CRC cis rs4423214 0.840 rs3794057 chr11:71186744 G/A cg13043300 chr11:71146211 DHCR7 -0.44 -5.98 -0.31 5.98e-9 Vitamin D levels; CRC cis rs4780401 0.573 rs8045673 chr16:11804385 C/A cg01061890 chr16:11836724 TXNDC11 -0.57 -8.06 -0.41 1.43e-14 Rheumatoid arthritis; CRC trans rs1814175 0.645 rs7395438 chr11:49877379 G/T cg15704280 chr7:45808275 SEPT13 -0.93 -16.5 -0.67 5.24e-45 Height; CRC cis rs9486715 0.830 rs4425602 chr6:96893906 G/A cg06623918 chr6:96969491 KIAA0776 1.02 20.47 0.75 1.25e-60 Headache; CRC cis rs12142240 0.698 rs17357759 chr1:46832534 A/G cg14993813 chr1:46806288 NSUN4 -0.46 -5.84 -0.31 1.24e-8 Menopause (age at onset); CRC cis rs4629180 1.000 rs11123889 chr2:102107180 G/A cg01388757 chr2:102091195 RFX8 0.65 8.7 0.43 1.61e-16 Chronic rhinosinusitis with nasal polyps; CRC cis rs73206853 0.610 rs73194020 chr12:111131366 G/A cg12870014 chr12:110450643 ANKRD13A 0.65 6.07 0.32 3.62e-9 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC cis rs4803468 0.967 rs4803461 chr19:41908871 G/A cg09537434 chr19:41945824 ATP5SL -0.92 -18.29 -0.71 4.59e-52 Height; CRC cis rs6754311 0.550 rs10173394 chr2:136522675 C/T cg15123519 chr2:136567270 LCT 0.3 5.65 0.3 3.53e-8 Mosquito bite size; CRC cis rs2522056 0.932 rs1012793 chr5:131781345 G/C cg24060327 chr5:131705240 SLC22A5 0.42 5.92 0.31 8.02e-9 Lymphocyte counts;Fibrinogen; CRC cis rs2688608 0.620 rs12253408 chr10:75495956 G/T cg16540259 chr10:75572220 NDST2 0.37 5.88 0.31 1.03e-8 Inflammatory bowel disease; CRC cis rs9910055 0.762 rs2631299 chr17:42219773 G/T cg13607699 chr17:42295918 UBTF 0.5 6.78 0.35 5.47e-11 Total body bone mineral density; CRC cis rs2535633 0.631 rs2710326 chr3:52995444 T/C cg15147215 chr3:52552868 STAB1 0.43 6.98 0.36 1.59e-11 Body mass index; CRC cis rs9435341 0.860 rs12406721 chr1:107563243 G/T cg09367891 chr1:107599246 PRMT6 0.63 9.17 0.45 5.28e-18 Facial morphology (factor 21, depth of nasal alae); CRC cis rs6479527 0.840 rs1590969 chr9:96756436 G/T cg14459158 chr9:96720562 NA 0.41 7.64 0.39 2.36e-13 Esophageal adenocarcinoma; CRC cis rs875971 0.964 rs778735 chr7:65814809 C/A cg00343986 chr7:65444356 GUSB 0.43 6.21 0.32 1.61e-9 Aortic root size; CRC cis rs4975709 0.589 rs4975746 chr5:1861069 G/A cg20790798 chr5:1857306 NA -0.45 -6.95 -0.36 1.96e-11 Cardiovascular disease risk factors; CRC cis rs4242434 0.889 rs11783129 chr8:22453426 G/A cg03733263 chr8:22462867 KIAA1967 0.97 17.92 0.7 1.37e-50 Exploratory eye movement dysfunction in schizophrenia (cognitive search score); CRC cis rs8180040 0.620 rs9858443 chr3:47086048 G/A cg02527881 chr3:46936655 PTH1R -0.34 -5.91 -0.31 8.74e-9 Colorectal cancer; CRC cis rs172166 0.538 rs1150686 chr6:28161271 T/G cg15845792 chr6:28175446 NA 0.65 9.78 0.47 5.56e-20 Cardiac Troponin-T levels; CRC cis rs7666738 0.830 rs11721726 chr4:98996314 T/C cg17366294 chr4:99064904 C4orf37 0.44 7.39 0.38 1.19e-12 Colonoscopy-negative controls vs population controls; CRC cis rs11764590 0.666 rs7787359 chr7:2090849 A/G cg14004847 chr7:1930337 MAD1L1 -0.45 -6.12 -0.32 2.72e-9 Neuroticism; CRC cis rs11711311 1.000 rs9865435 chr3:113450046 G/C cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.52 -7.0 -0.36 1.47e-11 IgG glycosylation; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg15171982 chr2:183903302 NCKAP1 0.46 7.88 0.4 4.78e-14 Liver disease severity in Alagille syndrome; CRC cis rs7626444 0.625 rs7638090 chr3:196476836 A/G cg12930392 chr3:196481615 PAK2 0.4 7.26 0.37 2.73e-12 Monocyte count; CRC cis rs12580194 0.958 rs7974512 chr12:55713606 A/G cg19537932 chr12:55886519 OR6C68 -0.54 -7.54 -0.38 4.53e-13 Cancer; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg10332296 chr1:42928798 NA 0.49 6.97 0.36 1.71e-11 Response to antipsychotic treatment; CRC cis rs7809950 1.000 rs2520271 chr7:107194949 C/T cg23024343 chr7:107201750 COG5 -0.61 -8.59 -0.43 3.52e-16 Coronary artery disease; CRC cis rs9611565 0.559 rs132771 chr22:42025350 A/G cg06634786 chr22:41940651 POLR3H 0.56 6.3 0.33 9.81e-10 Vitiligo; CRC cis rs853679 0.517 rs1340004 chr6:28103691 C/T cg02683197 chr6:28174875 NA 0.86 10.64 0.51 6.2e-23 Depression; CRC cis rs10504229 0.683 rs67077711 chr8:58139769 G/T cg24829409 chr8:58192753 C8orf71 -0.55 -8.03 -0.4 1.71e-14 Developmental language disorder (linguistic errors); CRC cis rs61008539 0.586 rs6959154 chr7:856320 C/T cg05535760 chr7:792225 HEATR2 -0.44 -5.78 -0.3 1.73e-8 Perceived unattractiveness to mosquitoes; CRC trans rs8123881 0.733 rs7268466 chr20:15810676 C/T cg24671245 chr10:76585406 MYST4 0.58 6.44 0.33 4.36e-10 Body mass index; CRC cis rs4665809 1.000 rs12475854 chr2:26267375 G/A cg27170947 chr2:26402098 FAM59B -0.44 -5.89 -0.31 9.43e-9 Gut microbiome composition (summer); CRC cis rs728616 0.867 rs12412257 chr10:81729603 C/T cg05935833 chr10:81318306 SFTPA2 -0.73 -7.99 -0.4 2.28e-14 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs1153858 1.000 rs2066090 chr15:45650018 T/C cg14582100 chr15:45693742 SPATA5L1 0.28 6.02 0.31 4.7e-9 Homoarginine levels; CRC cis rs4819052 0.851 rs7276103 chr21:46666078 G/A cg11663144 chr21:46675770 NA -0.68 -11.42 -0.53 1.18e-25 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg08722720 chr15:34331557 AVEN;CHRM5 0.49 7.26 0.37 2.9e-12 Response to antipsychotic treatment; CRC cis rs2404602 0.622 rs9635380 chr15:77103479 A/G cg03037974 chr15:76606532 NA -0.51 -7.16 -0.37 5.14e-12 Blood metabolite levels; CRC cis rs4713118 0.662 rs175954 chr6:28011585 A/G cg03623178 chr6:28175578 NA 0.87 12.53 0.57 1.06e-29 Parkinson's disease; CRC cis rs11098499 0.863 rs3822191 chr4:120428101 A/T cg09307838 chr4:120376055 NA 0.68 10.2 0.49 2.03e-21 Corneal astigmatism; CRC cis rs7635838 0.718 rs2594979 chr3:11381910 T/G cg00170343 chr3:11313890 ATG7 0.46 7.07 0.36 9.55e-12 HDL cholesterol; CRC cis rs5753618 0.561 rs2413047 chr22:31666026 A/G cg22777020 chr22:31556080 RNF185 -0.51 -5.86 -0.31 1.15e-8 Colorectal cancer; CRC cis rs9868809 0.881 rs7631574 chr3:48663046 A/G cg07636037 chr3:49044803 WDR6 0.58 6.16 0.32 2.07e-9 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; CRC cis rs11098499 1.000 rs35643470 chr4:120184948 T/C cg24375607 chr4:120327624 NA 0.42 6.49 0.34 3.2e-10 Corneal astigmatism; CRC trans rs208520 0.955 rs9345808 chr6:67008262 C/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.67 8.16 0.41 7.36e-15 Exhaled nitric oxide output; CRC cis rs11098499 0.775 rs67281037 chr4:120281157 G/C cg09307838 chr4:120376055 NA 0.68 10.53 0.5 1.51e-22 Corneal astigmatism; CRC cis rs6963495 0.818 rs6957192 chr7:105150255 A/C cg02135003 chr7:105160482 PUS7 0.86 12.08 0.55 4.74e-28 Bipolar disorder (body mass index interaction); CRC cis rs734999 0.505 rs60687045 chr1:2539603 G/A cg18854424 chr1:2615690 NA 0.41 7.83 0.4 6.66e-14 Ulcerative colitis; CRC cis rs6424115 0.830 rs3003335 chr1:24200052 A/G cg10978503 chr1:24200527 CNR2 0.62 11.22 0.53 6.02e-25 Immature fraction of reticulocytes; CRC cis rs2976388 0.587 rs2717606 chr8:143799496 G/A cg05569086 chr8:143859399 LYNX1 0.38 6.61 0.34 1.58e-10 Urinary tract infection frequency; CRC cis rs72781680 1.000 rs17762782 chr2:24126493 A/G cg08917208 chr2:24149416 ATAD2B 0.9 9.14 0.45 6.81e-18 Lymphocyte counts; CRC cis rs1223397 0.651 rs2458309 chr6:13312086 G/A cg20827128 chr6:13274284 PHACTR1 0.38 5.81 0.3 1.5e-8 Blood pressure; CRC cis rs4474465 0.850 rs4565922 chr11:78260699 A/G cg27205649 chr11:78285834 NARS2 0.51 6.68 0.35 1.01e-10 Alzheimer's disease (survival time); CRC cis rs9287719 0.967 rs2110776 chr2:10748810 A/G cg00105475 chr2:10696890 NA 0.45 7.17 0.37 4.87e-12 Prostate cancer; CRC cis rs853679 0.517 rs9468292 chr6:28095355 G/A cg02683197 chr6:28174875 NA 0.85 10.52 0.5 1.71e-22 Depression; CRC cis rs9303280 0.806 rs11078928 chr17:38064469 T/C cg00129232 chr17:37814104 STARD3 -0.48 -7.49 -0.38 6.55e-13 Self-reported allergy; CRC cis rs713587 0.563 rs11686663 chr2:25107759 C/T cg22495460 chr2:25135724 ADCY3 -0.88 -17.37 -0.69 2.07e-48 Body mass index in non-asthmatics; CRC cis rs853679 0.517 rs4713148 chr6:28115921 G/A cg15786705 chr6:28176104 NA 0.78 9.83 0.48 3.57e-20 Depression; CRC trans rs9291683 0.595 rs11722930 chr4:10035454 G/A cg26043149 chr18:55253948 FECH 0.52 8.11 0.41 9.94e-15 Bone mineral density; CRC cis rs477895 0.713 rs35095324 chr11:63948412 G/A cg05016508 chr11:63871570 FLRT1;MACROD1 0.55 7.03 0.36 1.21e-11 Mean platelet volume; CRC cis rs11098499 0.566 rs7664440 chr4:120578540 A/G cg24375607 chr4:120327624 NA 0.49 7.34 0.38 1.67e-12 Corneal astigmatism; CRC trans rs11098499 0.954 rs1546505 chr4:120241224 A/G cg25214090 chr10:38739885 LOC399744 0.62 9.67 0.47 1.21e-19 Corneal astigmatism; CRC cis rs10484885 0.553 rs2182864 chr6:90235552 C/G cg13799429 chr6:90582589 CASP8AP2 -0.54 -6.07 -0.32 3.43e-9 QRS interval (sulfonylurea treatment interaction); CRC cis rs7927592 0.513 rs653056 chr11:68203625 T/C cg16797656 chr11:68205561 LRP5 0.59 10.88 0.51 9.05e-24 Total body bone mineral density; CRC cis rs1475911 0.507 rs11702347 chr21:43526454 C/T cg14562523 chr21:43528734 C21orf128;UMODL1 -0.65 -8.73 -0.43 1.32e-16 IgG glycosylation; CRC cis rs9875589 0.533 rs12490233 chr3:13977365 G/A cg14375111 chr3:14165186 TMEM43;CHCHD4 0.38 5.82 0.31 1.39e-8 Ovarian reserve; CRC cis rs644799 0.932 rs10831447 chr11:95663017 C/T cg03916912 chr11:95522834 CEP57;FAM76B -0.8 -12.53 -0.57 1.05e-29 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs13333054 0.950 rs68143182 chr16:86005838 C/T cg04454285 chr16:86016317 NA 0.76 10.76 0.51 2.48e-23 Multiple sclerosis; CRC cis rs9325144 0.555 rs6582576 chr12:38701230 C/T cg13010199 chr12:38710504 ALG10B -0.39 -5.75 -0.3 2.05e-8 Morning vs. evening chronotype; CRC cis rs8141529 0.764 rs5762854 chr22:29246278 T/C cg15103426 chr22:29168792 CCDC117 0.61 8.8 0.44 7.89e-17 Lymphocyte counts; CRC cis rs10256972 0.684 rs4724039 chr7:1111633 A/G cg03188948 chr7:1209495 NA 0.41 5.96 0.31 6.45e-9 Longevity;Endometriosis; CRC cis rs13191362 1.000 rs67840803 chr6:163049048 C/T cg14584255 chr6:163149320 PACRG;PARK2 0.43 6.04 0.32 4.17e-9 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs6500602 0.627 rs11639998 chr16:4527109 T/C cg06139259 chr16:4526053 HMOX2;NMRAL1 0.54 6.92 0.36 2.33e-11 Schizophrenia; CRC cis rs17826219 0.706 rs8075107 chr17:29106649 C/A cg01831904 chr17:28903510 LRRC37B2 -0.63 -6.45 -0.33 4.07e-10 Body mass index; CRC cis rs6570726 0.755 rs2092297 chr6:145893765 A/G cg13319975 chr6:146136371 FBXO30 -0.42 -6.22 -0.32 1.53e-9 Lobe attachment (rater-scored or self-reported); CRC trans rs7819412 0.875 rs11250121 chr8:11060311 A/C cg08975724 chr8:8085496 FLJ10661 -0.4 -6.03 -0.32 4.34e-9 Triglycerides; CRC cis rs3857067 1.000 rs1588382 chr4:95017589 C/T cg11021082 chr4:95130006 SMARCAD1 -0.4 -6.05 -0.32 3.9e-9 QT interval; CRC trans rs2408955 0.504 rs11168441 chr12:48576054 G/A cg00419564 chr1:153508860 S100A6 0.47 6.1 0.32 2.93e-9 Glycated hemoglobin levels; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg23729963 chr8:94753249 RBM12B 0.43 6.23 0.32 1.45e-9 Response to antipsychotic treatment; CRC cis rs34172651 0.917 rs8049667 chr16:24773524 G/A cg04756594 chr16:24857601 SLC5A11 0.24 5.61 0.3 4.28e-8 Intelligence (multi-trait analysis); CRC cis rs875971 0.862 rs6460282 chr7:65691246 T/C cg12463550 chr7:65579703 CRCP -0.5 -6.79 -0.35 5.2e-11 Aortic root size; CRC cis rs7274811 0.779 rs34145153 chr20:32159067 C/T cg07470512 chr20:32255052 NECAB3;C20orf134 -0.45 -6.06 -0.32 3.81e-9 Height; CRC cis rs2019137 0.539 rs6755040 chr2:113981137 T/C cg02675527 chr2:114030824 PAX8;LOC440839 -0.41 -6.2 -0.32 1.66e-9 Lymphocyte counts; CRC cis rs16852403 0.519 rs421767 chr1:178096922 C/T cg00404053 chr1:178313656 RASAL2 -0.49 -6.58 -0.34 1.87e-10 Childhood ear infection; CRC cis rs950169 0.649 rs12905952 chr15:84691261 G/A cg17507749 chr15:85114479 UBE2QP1 0.66 8.77 0.44 9.86e-17 Schizophrenia; CRC cis rs9894429 0.966 rs10871499 chr17:79589006 G/A cg21984481 chr17:79567631 NPLOC4 -0.53 -9.8 -0.48 4.52e-20 Eye color traits; CRC trans rs2303319 0.504 rs56009150 chr2:162598582 T/C cg11326919 chr17:43324904 LOC100133991 -0.65 -6.03 -0.32 4.51e-9 Cognitive function; CRC cis rs2153535 0.580 rs2225765 chr6:8481785 A/G cg07606381 chr6:8435919 SLC35B3 0.67 10.69 0.51 4.33e-23 Motion sickness; CRC cis rs6860806 0.507 rs2631371 chr5:131703691 G/A cg09877947 chr5:131593287 PDLIM4 -0.45 -7.33 -0.37 1.79e-12 Breast cancer; CRC cis rs7647973 0.516 rs4955419 chr3:49200692 T/A cg03060546 chr3:49711283 APEH 0.44 6.38 0.33 5.97e-10 Menarche (age at onset); CRC cis rs4474465 1.000 rs10899520 chr11:78183370 C/T cg27205649 chr11:78285834 NARS2 -0.48 -5.8 -0.3 1.57e-8 Alzheimer's disease (survival time); CRC cis rs1559088 0.947 rs12461219 chr19:33550633 C/G cg27124370 chr19:33622961 WDR88 0.41 5.71 0.3 2.49e-8 Bone ultrasound measurement (broadband ultrasound attenuation); CRC trans rs7618501 0.815 rs3819325 chr3:49843723 T/C cg21665057 chr3:196295764 WDR53;FBXO45 0.85 15.39 0.65 1.24e-40 Intelligence (multi-trait analysis); CRC cis rs13064411 0.597 rs2291905 chr3:113010466 C/T cg18753928 chr3:113234510 CCDC52 -0.57 -8.73 -0.43 1.29e-16 Response to simvastatin treatment (PCSK9 protein level change); CRC cis rs12143943 0.966 rs3747632 chr1:204587240 G/A cg17419461 chr1:204415978 PIK3C2B 0.42 6.34 0.33 7.51e-10 Cognitive performance; CRC cis rs2243480 1.000 rs316321 chr7:65611613 G/A cg25985355 chr7:65971099 NA -0.56 -6.33 -0.33 8.11e-10 Diabetic kidney disease; CRC trans rs6550704 0.687 rs9865314 chr3:22634337 A/G cg20552752 chr15:90895281 ZNF774 -0.4 -6.02 -0.31 4.63e-9 Daytime sleep phenotypes; CRC cis rs6570726 0.791 rs6915094 chr6:145883540 C/G cg13319975 chr6:146136371 FBXO30 -0.44 -6.54 -0.34 2.39e-10 Lobe attachment (rater-scored or self-reported); CRC cis rs2243480 1.000 rs431076 chr7:65600320 A/C cg25985355 chr7:65971099 NA -0.52 -5.98 -0.31 5.86e-9 Diabetic kidney disease; CRC cis rs4926298 1.000 rs8104231 chr19:13159569 A/T cg23899408 chr19:12877188 HOOK2 -0.45 -6.26 -0.33 1.21e-9 Bipolar disorder; CRC cis rs2180341 1.000 rs6903878 chr6:127638600 C/G cg24812749 chr6:127587940 RNF146 0.94 13.66 0.6 6.02e-34 Breast cancer; CRC cis rs9479482 1.000 rs5006620 chr6:150336665 C/T cg25797454 chr6:150327115 RAET1K 0.39 6.51 0.34 2.76e-10 Alopecia areata; CRC cis rs34375054 0.624 rs7132026 chr12:125678096 A/G cg06287003 chr12:125626642 AACS 0.55 7.28 0.37 2.5e-12 Post bronchodilator FEV1/FVC ratio; CRC cis rs1355223 0.583 rs1396880 chr11:34870552 C/T cg24088639 chr11:34937564 PDHX;APIP 0.59 8.6 0.43 3.41e-16 Systemic lupus erythematosus and Systemic sclerosis; CRC cis rs2204008 0.548 rs8189475 chr12:38037115 C/T cg26384229 chr12:38710491 ALG10B 0.64 9.81 0.48 4.12e-20 Bladder cancer; CRC cis rs8078723 1.000 rs4794824 chr17:38179290 G/A cg17344932 chr17:38183730 MED24;SNORD124 -0.46 -7.09 -0.36 8.23e-12 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); CRC cis rs6912958 0.559 rs242267 chr6:88061837 A/G cg08069147 chr6:88032118 GJB7;C6orf162 -0.73 -11.82 -0.55 3.99e-27 Monocyte percentage of white cells; CRC cis rs4665809 0.941 rs2289021 chr2:26362515 A/C cg04944784 chr2:26401820 FAM59B 0.49 5.9 0.31 9.16e-9 Gut microbiome composition (summer); CRC cis rs6502050 0.805 rs56020943 chr17:80105248 C/A cg25804541 chr17:80189381 SLC16A3 -0.31 -5.97 -0.31 6.08e-9 Life satisfaction; CRC cis rs13108904 0.518 rs4974603 chr4:1343168 C/T cg24560729 chr4:1342394 KIAA1530 0.44 7.45 0.38 8.23e-13 Obesity-related traits; CRC cis rs9491140 1.000 rs12192208 chr6:124693764 C/A cg22366943 chr6:124882293 NKAIN2 0.35 5.64 0.3 3.71e-8 Neuroticism; CRC trans rs8002861 0.664 rs2184882 chr13:44450346 C/T cg12856521 chr11:46389249 DGKZ 0.41 6.77 0.35 6.03e-11 Leprosy; CRC cis rs6835098 0.962 rs10027704 chr4:174083107 T/C cg08422745 chr4:174089978 GALNT7 -0.94 -15.34 -0.65 1.99e-40 Dementia and core Alzheimer's disease neuropathologic changes; CRC cis rs2115630 1.000 rs11854291 chr15:85363708 T/C cg09876464 chr15:85330779 ZNF592 0.46 8.06 0.41 1.38e-14 P wave terminal force; CRC cis rs9368481 0.761 rs9357028 chr6:26967224 T/G cg12292205 chr6:26970375 C6orf41 -0.73 -11.84 -0.55 3.64e-27 Autism spectrum disorder or schizophrenia; CRC cis rs4676482 0.541 rs17735402 chr3:39205176 C/T cg02254461 chr3:39195904 CSRNP1 0.68 7.27 0.37 2.7e-12 Colonoscopy-negative controls vs population controls; CRC cis rs8062405 0.824 rs7191618 chr16:28565667 C/G cg16576597 chr16:28551801 NUPR1 0.46 6.96 0.36 1.88e-11 Cognitive ability (multi-trait analysis);Cognitive ability; CRC cis rs2204008 0.837 rs8189467 chr12:38241956 T/C cg26384229 chr12:38710491 ALG10B 0.66 9.19 0.45 4.44e-18 Bladder cancer; CRC cis rs2692947 0.740 rs60452119 chr2:96420050 T/C cg23100626 chr2:96804247 ASTL 0.26 6.72 0.35 7.82e-11 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; CRC cis rs12701220 0.689 rs12701824 chr7:1102364 G/A cg02733842 chr7:1102375 C7orf50 -1.04 -13.68 -0.6 4.68e-34 Bronchopulmonary dysplasia; CRC cis rs853679 0.517 rs9380052 chr6:28064623 A/G cg12273811 chr6:28175739 NA 0.74 9.41 0.46 8.56e-19 Depression; CRC cis rs3806843 0.676 rs2245640 chr5:140029958 A/G cg19875535 chr5:140030758 IK -0.68 -11.65 -0.54 1.64e-26 Depressive symptoms (multi-trait analysis); CRC cis rs1256061 0.603 rs928554 chr14:64694195 C/T cg23250157 chr14:64679961 SYNE2 0.48 7.44 0.38 8.79e-13 Hemoglobin concentration;Red blood cell count;Hematocrit; CRC cis rs11098499 0.754 rs2036857 chr4:120249240 T/C cg09307838 chr4:120376055 NA 0.62 9.66 0.47 1.37e-19 Corneal astigmatism; CRC cis rs17067123 0.614 rs35522192 chr4:180064376 C/A cg26610307 chr4:180072759 NA -0.55 -6.57 -0.34 1.97e-10 Response to hepatitis C treatment; CRC cis rs6504950 0.745 rs12603899 chr17:53010098 T/C cg26251398 chr17:52985966 TOM1L1 0.37 5.69 0.3 2.8e-8 Breast cancer; CRC cis rs9372498 0.536 rs9489442 chr6:118885950 A/C cg10217327 chr6:118973057 C6orf204 0.51 5.86 0.31 1.12e-8 Diastolic blood pressure; CRC cis rs7552404 0.655 rs5745336 chr1:76273519 G/A cg22875332 chr1:76189707 ACADM 0.57 7.46 0.38 7.56e-13 Blood metabolite levels;Acylcarnitine levels; CRC cis rs7762018 0.607 rs61740334 chr6:170047902 T/A cg19338460 chr6:170058176 WDR27 -1.24 -10.25 -0.49 1.46e-21 Thiazide-induced adverse metabolic effects in hypertensive patients; CRC cis rs9814567 1.000 rs1814337 chr3:134200682 C/T cg06541857 chr3:134203789 ANAPC13;CEP63 -0.41 -6.21 -0.32 1.62e-9 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs2204008 0.570 rs1315664 chr12:38138274 A/G cg13010199 chr12:38710504 ALG10B -0.41 -5.99 -0.31 5.54e-9 Bladder cancer; CRC cis rs10504229 1.000 rs67344620 chr8:58187537 C/A cg22535103 chr8:58192502 C8orf71 -0.82 -12.27 -0.56 9.63e-29 Developmental language disorder (linguistic errors); CRC cis rs6921919 0.583 rs4642462 chr6:28389251 G/C cg21251018 chr6:28226885 NKAPL 0.41 6.26 0.33 1.19e-9 Autism spectrum disorder or schizophrenia; CRC cis rs12282928 1.000 rs10838872 chr11:48336147 C/G cg20307385 chr11:47447363 PSMC3 0.47 5.8 0.3 1.52e-8 Migraine - clinic-based; CRC cis rs56114371 0.777 rs200482 chr6:27773904 G/A cg08798685 chr6:27730294 NA -0.62 -6.06 -0.32 3.82e-9 Breast cancer; CRC cis rs4073416 0.518 rs7141536 chr14:65987312 T/A cg03016385 chr14:66212404 NA -0.44 -6.1 -0.32 2.93e-9 N-glycan levels; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg26366360 chr17:79895491 PYCR1 0.43 6.2 0.32 1.71e-9 Response to antipsychotic treatment; CRC cis rs7772486 0.790 rs9497424 chr6:146225271 C/A cg23711669 chr6:146136114 FBXO30 -0.67 -11.43 -0.53 1.05e-25 Lobe attachment (rater-scored or self-reported); CRC cis rs4713118 0.699 rs200978 chr6:27853168 C/G cg25164649 chr6:28176230 NA 0.61 7.68 0.39 1.87e-13 Parkinson's disease; CRC cis rs875971 1.000 rs11974264 chr7:65647582 C/G cg00343986 chr7:65444356 GUSB -0.45 -6.56 -0.34 2.11e-10 Aortic root size; CRC cis rs9534288 0.577 rs2897029 chr13:46682821 T/C cg15192986 chr13:46630673 CPB2 -0.58 -7.65 -0.39 2.22e-13 Blood protein levels; CRC cis rs10504229 0.953 rs75545548 chr8:58172816 T/C cg05313129 chr8:58192883 C8orf71 -0.47 -6.99 -0.36 1.49e-11 Developmental language disorder (linguistic errors); CRC trans rs8035957 1.000 rs4924273 chr15:38846738 C/G cg05995172 chr11:57434667 ZDHHC5 -0.51 -6.01 -0.31 4.82e-9 Type 1 diabetes; CRC cis rs9534288 0.762 rs1571053 chr13:46554854 G/A cg15192986 chr13:46630673 CPB2 -0.67 -9.86 -0.48 2.81e-20 Blood protein levels; CRC cis rs12188164 0.582 rs80273890 chr5:483057 C/T cg26850624 chr5:429559 AHRR -0.73 -9.57 -0.47 2.68e-19 Cystic fibrosis severity; CRC cis rs7659604 0.539 rs1507995 chr4:122748308 G/A cg06713675 chr4:122721982 EXOSC9 -0.5 -8.25 -0.41 3.91e-15 Type 2 diabetes; CRC cis rs3106136 0.901 rs17376488 chr4:95226548 T/C cg11021082 chr4:95130006 SMARCAD1 -0.46 -7.01 -0.36 1.33e-11 Capecitabine sensitivity; CRC cis rs7617773 0.851 rs6775179 chr3:48313418 T/C cg11946769 chr3:48343235 NME6 0.63 8.73 0.43 1.31e-16 Coronary artery disease; CRC cis rs6121246 0.529 rs6060195 chr20:30185638 C/T cg13852791 chr20:30311386 BCL2L1 0.6 8.21 0.41 5.04e-15 Mean corpuscular hemoglobin; CRC cis rs2019137 0.560 rs7421852 chr2:113990261 G/A cg21610815 chr2:113994035 PAX8;LOC654433;LOC440839 0.57 8.3 0.42 2.65e-15 Lymphocyte counts; CRC cis rs2836950 0.545 rs2836959 chr21:40623668 T/G cg17971929 chr21:40555470 PSMG1 -0.59 -8.56 -0.43 4.45e-16 Menarche (age at onset); CRC cis rs4662945 0.603 rs2406981 chr2:130305487 A/G cg05962382 chr2:130345044 NA -0.48 -8.18 -0.41 6.12e-15 Response to cytidine analogues (gemcitabine); CRC trans rs9956878 0.555 rs8085188 chr18:73544676 A/G cg24426209 chr7:92157939 PEX1;C7orf64 -0.38 -6.44 -0.33 4.2e-10 Obesity-related traits; CRC trans rs35110281 0.805 rs4818855 chr21:45038951 C/T cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.4 6.44 0.33 4.15e-10 Mean corpuscular volume; CRC cis rs651907 0.557 rs3806654 chr3:101396529 G/C cg12386194 chr3:101231763 SENP7 0.47 6.78 0.35 5.53e-11 Colorectal cancer; CRC cis rs72772090 0.539 rs72773942 chr5:96123366 G/A cg17330273 chr5:96107758 CAST;ERAP1 -0.63 -5.85 -0.31 1.18e-8 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs6502050 0.835 rs7222057 chr17:80087647 C/A cg25804541 chr17:80189381 SLC16A3 -0.31 -6.01 -0.31 4.92e-9 Life satisfaction; CRC cis rs9388451 0.874 rs3734634 chr6:126111800 G/A cg10911889 chr6:126070802 HEY2 0.39 5.94 0.31 7.2e-9 Brugada syndrome; CRC cis rs10504229 0.775 rs17805026 chr8:58160637 A/C cg22535103 chr8:58192502 C8orf71 -0.7 -8.43 -0.42 1.07e-15 Developmental language disorder (linguistic errors); CRC cis rs6681460 1.000 rs1562217 chr1:67073566 C/T cg02459107 chr1:67143332 SGIP1 -0.45 -7.8 -0.4 8.06e-14 Presence of antiphospholipid antibodies; CRC cis rs769267 0.929 rs2905431 chr19:19482882 G/A cg02546618 chr19:19431379 KIAA0892;SF4 -0.45 -6.25 -0.33 1.29e-9 Tonsillectomy; CRC trans rs4263408 0.934 rs9683743 chr4:39703194 A/C cg14830952 chr8:86089500 E2F5 -0.41 -6.27 -0.33 1.14e-9 Plasma amyloid beta peptide concentrations (ABx-40); CRC cis rs6748734 0.625 rs4312490 chr2:241821481 A/G cg16358738 chr2:241808595 AGXT -0.39 -6.73 -0.35 7.43e-11 Urinary metabolites; CRC cis rs11212617 0.934 rs10890834 chr11:108286443 C/T cg01991180 chr11:108092276 ATM;NPAT 0.42 6.34 0.33 7.39e-10 Response to metformin in type 2 diabetes (glycemic); CRC cis rs6951245 1.000 rs118059236 chr7:1073202 A/C cg18402987 chr7:1209562 NA 0.64 6.77 0.35 6.03e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs8031584 0.678 rs4779790 chr15:31164595 T/C cg08704250 chr15:31115839 NA -0.56 -9.86 -0.48 2.97e-20 Huntington's disease progression; CRC cis rs11583043 0.831 rs6667818 chr1:101412313 A/T cg00063077 chr1:101360652 SLC30A7;EXTL2 0.48 6.57 0.34 1.99e-10 Ulcerative colitis;Inflammatory bowel disease; CRC trans rs7726839 0.540 rs28364691 chr5:664084 G/A cg25482853 chr8:67687455 SGK3 1.16 13.2 0.59 3.15e-32 Obesity-related traits; CRC cis rs7586879 0.593 rs10200566 chr2:25130462 G/T cg22495460 chr2:25135724 ADCY3 0.84 15.85 0.66 2e-42 Body mass index; CRC cis rs1005277 0.522 rs9418276 chr10:37940116 G/T cg25517755 chr10:38738941 LOC399744 -0.4 -5.62 -0.3 4.01e-8 Extrinsic epigenetic age acceleration; CRC cis rs6570726 0.791 rs9376945 chr6:145828080 T/A cg13319975 chr6:146136371 FBXO30 -0.44 -6.66 -0.34 1.13e-10 Lobe attachment (rater-scored or self-reported); CRC cis rs1448094 0.817 rs7972773 chr12:86340774 A/C cg00310523 chr12:86230176 RASSF9 0.43 7.26 0.37 2.86e-12 Major depressive disorder; CRC cis rs9311474 0.629 rs7636227 chr3:52566682 G/A cg17372223 chr3:52568218 NT5DC2 0.4 6.17 0.32 2.03e-9 Electroencephalogram traits; CRC cis rs2204008 0.806 rs11520229 chr12:38246448 C/A cg13010199 chr12:38710504 ALG10B 0.45 5.75 0.3 2.07e-8 Bladder cancer; CRC cis rs4862750 0.915 rs6835681 chr4:187903476 A/G cg07414643 chr4:187882934 NA 0.42 7.34 0.37 1.73e-12 Lobe attachment (rater-scored or self-reported); CRC cis rs6460942 0.915 rs62448599 chr7:12453764 C/T cg20607287 chr7:12443886 VWDE -0.66 -6.93 -0.36 2.17e-11 Coronary artery disease; CRC trans rs2727020 0.521 rs7930855 chr11:49521660 C/T cg15704280 chr7:45808275 SEPT13 0.76 10.05 0.48 6.73e-21 Coronary artery disease; CRC cis rs7618915 0.547 rs4687548 chr3:52666650 A/T cg18404041 chr3:52824283 ITIH1 -0.42 -8.65 -0.43 2.35e-16 Bipolar disorder; CRC cis rs12143943 0.966 rs12135707 chr1:204556223 C/T cg17419461 chr1:204415978 PIK3C2B 0.42 6.35 0.33 7.03e-10 Cognitive performance; CRC cis rs6918586 0.658 rs198814 chr6:26127759 A/G cg18357526 chr6:26021779 HIST1H4A -0.5 -7.47 -0.38 7.38e-13 Schizophrenia; CRC cis rs5758511 0.633 rs5751258 chr22:42663871 C/G cg00645731 chr22:42541494 CYP2D7P1 0.64 9.83 0.48 3.73e-20 Birth weight; CRC trans rs4942242 0.640 rs17460861 chr13:44230078 C/G cg19169023 chr15:41853346 TYRO3 0.65 9.13 0.45 6.87e-18 Response to tocilizumab in rheumatoid arthritis; CRC cis rs7666738 0.830 rs6839203 chr4:98839814 C/G cg17366294 chr4:99064904 C4orf37 0.43 6.89 0.35 2.93e-11 Colonoscopy-negative controls vs population controls; CRC cis rs4713118 0.513 rs149972 chr6:27983227 C/T cg15845792 chr6:28175446 NA 0.77 11.44 0.53 9.43e-26 Parkinson's disease; CRC cis rs6500602 0.609 rs7202910 chr16:4518948 T/A cg14951292 chr16:4525986 HMOX2;NMRAL1 0.72 10.21 0.49 1.89e-21 Schizophrenia; CRC cis rs11098499 0.697 rs11941899 chr4:120382758 C/A cg24375607 chr4:120327624 NA 0.5 7.72 0.39 1.4e-13 Corneal astigmatism; CRC cis rs523522 0.962 rs4766968 chr12:120947788 G/C cg27279351 chr12:120934652 DYNLL1 0.78 11.48 0.53 7.05e-26 High light scatter reticulocyte count; CRC cis rs10193935 0.901 rs10174872 chr2:42459807 T/G cg27598129 chr2:42591480 NA -0.74 -8.22 -0.41 4.9e-15 Colonoscopy-negative controls vs population controls; CRC cis rs7635838 0.892 rs9874535 chr3:11463730 A/G cg00170343 chr3:11313890 ATG7 0.41 6.24 0.33 1.32e-9 HDL cholesterol; CRC cis rs6963495 0.872 rs73190193 chr7:105164852 A/G cg13798780 chr7:105162888 PUS7 0.68 8.05 0.41 1.55e-14 Bipolar disorder (body mass index interaction); CRC cis rs243505 0.691 rs243483 chr7:148449163 A/G cg09806900 chr7:148480153 CUL1 -0.59 -7.39 -0.38 1.23e-12 Inflammatory bowel disease;Crohn's disease; CRC cis rs9309473 0.948 rs10183818 chr2:73714556 A/G cg20560298 chr2:73613845 ALMS1 -0.52 -5.86 -0.31 1.12e-8 Metabolite levels; CRC cis rs7618915 0.547 rs62253700 chr3:52625019 T/A cg18404041 chr3:52824283 ITIH1 -0.42 -8.75 -0.43 1.14e-16 Bipolar disorder; CRC cis rs2404602 1.000 rs12898430 chr15:76874923 G/A cg22467129 chr15:76604101 ETFA -0.37 -6.15 -0.32 2.22e-9 Blood metabolite levels; CRC cis rs6938 0.534 rs11636892 chr15:75266049 G/C cg21523564 chr15:75251491 NA 0.41 6.07 0.32 3.48e-9 Breast cancer; CRC cis rs66573146 0.634 rs55633489 chr4:6988745 C/A cg00086871 chr4:6988644 TBC1D14 1.01 8.46 0.42 8.84e-16 Granulocyte percentage of myeloid white cells; CRC cis rs56775891 1.000 rs56775891 chr18:77575613 C/T cg24058013 chr18:77568902 NA -0.44 -6.96 -0.36 1.83e-11 Schizophrenia; CRC cis rs2836974 0.897 rs8132419 chr21:40527827 C/T cg11644478 chr21:40555479 PSMG1 0.82 13.39 0.59 6.26e-33 Cognitive function; CRC trans rs8002861 0.905 rs12875768 chr13:44428305 C/T cg12856521 chr11:46389249 DGKZ -0.42 -6.63 -0.34 1.41e-10 Leprosy; CRC cis rs737337 0.623 rs3826815 chr19:11332505 C/T cg00586551 chr19:11347513 LOC55908;DOCK6 0.8 8.84 0.44 5.7e-17 HDL cholesterol;HDL cholesterol levels; CRC cis rs7072216 0.763 rs942805 chr10:100168372 G/A cg26618903 chr10:100175079 PYROXD2 -0.55 -9.25 -0.45 2.91e-18 Metabolite levels; CRC trans rs8002861 0.664 rs4942247 chr13:44405107 A/G cg17145862 chr1:211918768 LPGAT1 0.59 10.1 0.49 4.48e-21 Leprosy; CRC cis rs1552244 0.572 rs73117481 chr3:10160132 C/T cg00166722 chr3:10149974 C3orf24 0.65 7.7 0.39 1.56e-13 Alzheimer's disease; CRC cis rs2075371 0.966 rs1619682 chr7:133996703 T/G cg20476274 chr7:133979776 SLC35B4 0.8 14.34 0.62 1.44e-36 Mean platelet volume; CRC cis rs9926296 0.542 rs12599531 chr16:89909401 C/T cg03605463 chr16:89740564 NA 0.42 6.06 0.32 3.72e-9 Vitiligo; CRC trans rs1814175 0.817 rs10839358 chr11:49770972 G/A cg03929089 chr4:120376271 NA -0.97 -19.26 -0.73 6.71e-56 Height; CRC cis rs7274811 0.681 rs291705 chr20:31969658 A/G cg07470512 chr20:32255052 NECAB3;C20orf134 -0.41 -5.81 -0.3 1.51e-8 Height; CRC cis rs17270561 0.666 rs9356988 chr6:25777481 G/A cg17691542 chr6:26056736 HIST1H1C 0.68 8.63 0.43 2.72e-16 Iron status biomarkers; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg16458507 chr12:113376293 OAS3 0.41 6.72 0.35 8.06e-11 Liver disease severity in Alagille syndrome; CRC cis rs7412746 0.658 rs57818453 chr1:150763139 G/A cg18016565 chr1:150552671 MCL1 0.44 6.06 0.32 3.76e-9 Melanoma; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg24677501 chr11:64008407 FKBP2 0.46 6.54 0.34 2.38e-10 Response to antipsychotic treatment; CRC cis rs7727544 0.618 rs2631367 chr5:131705458 C/G cg11843238 chr5:131593191 PDLIM4 -0.33 -6.08 -0.32 3.42e-9 Blood metabolite levels; CRC cis rs9462027 0.628 rs9689820 chr6:34752963 C/G cg07306190 chr6:34760872 UHRF1BP1 -0.35 -6.24 -0.33 1.31e-9 Systemic lupus erythematosus; CRC cis rs4481887 0.962 rs10749653 chr1:248481384 C/G cg13385794 chr1:248469461 NA 0.39 6.7 0.35 9.32e-11 Common traits (Other); CRC cis rs2976388 0.556 rs10956985 chr8:143818750 C/A cg20041105 chr8:143859282 LYNX1 -0.43 -6.69 -0.35 9.5e-11 Urinary tract infection frequency; CRC trans rs1814175 0.817 rs2866863 chr11:49953242 C/T cg15704280 chr7:45808275 SEPT13 -0.99 -19.54 -0.73 5.49e-57 Height; CRC cis rs13144136 0.775 rs13136927 chr4:10669522 A/C cg10242279 chr4:10666415 CLNK -0.33 -5.62 -0.3 3.98e-8 Resistance to antihypertensive treatment in hypertension; CRC cis rs875971 0.825 rs66981195 chr7:66079035 C/A cg11764359 chr7:65958608 NA -0.6 -8.93 -0.44 3.13e-17 Aortic root size; CRC cis rs9733 0.596 rs72702557 chr1:150680130 A/G cg10589385 chr1:150898437 SETDB1 0.28 5.96 0.31 6.66e-9 Tonsillectomy; CRC trans rs4942242 0.659 rs1105586 chr13:44232633 C/T cg19169023 chr15:41853346 TYRO3 0.58 9.34 0.46 1.45e-18 Response to tocilizumab in rheumatoid arthritis; CRC trans rs1005277 0.579 rs1621040 chr10:38497232 T/C cg11292332 chr7:45801988 SEPT13 -0.38 -7.02 -0.36 1.26e-11 Extrinsic epigenetic age acceleration; CRC cis rs2013441 1.000 rs9896709 chr17:20180550 G/A cg13482628 chr17:19912719 NA -0.4 -6.19 -0.32 1.75e-9 Obesity-related traits; CRC cis rs875971 0.895 rs6460278 chr7:65662736 T/C cg18252515 chr7:66147081 NA 0.41 5.72 0.3 2.34e-8 Aortic root size; CRC cis rs9303280 0.806 rs12936409 chr17:38043649 C/T cg00129232 chr17:37814104 STARD3 -0.46 -7.21 -0.37 3.87e-12 Self-reported allergy; CRC cis rs747650 0.504 rs11601798 chr11:47158392 A/G cg19486271 chr11:47235900 DDB2 0.45 5.97 0.31 6.24e-9 Acne (severe); CRC cis rs7772486 0.875 rs9403764 chr6:146360582 G/A cg23711669 chr6:146136114 FBXO30 0.68 11.87 0.55 2.69e-27 Lobe attachment (rater-scored or self-reported); CRC cis rs3785574 0.962 rs16947051 chr17:61790917 G/C cg11494091 chr17:61959527 GH2 0.37 5.71 0.3 2.47e-8 Height; CRC cis rs2075371 0.501 rs1646653 chr7:134024686 A/G cg02659138 chr7:134003124 SLC35B4 0.34 5.7 0.3 2.61e-8 Mean platelet volume; CRC cis rs2836974 0.899 rs6517514 chr21:40527095 G/T cg17971929 chr21:40555470 PSMG1 0.84 12.96 0.58 2.62e-31 Cognitive function; CRC cis rs6089584 0.854 rs6061407 chr20:60622048 A/C cg23463467 chr20:60627584 TAF4 0.33 5.79 0.3 1.61e-8 Body mass index; CRC cis rs6681460 1.000 rs9662943 chr1:67121132 A/G cg02459107 chr1:67143332 SGIP1 -0.46 -7.59 -0.39 3.27e-13 Presence of antiphospholipid antibodies; CRC cis rs7647973 0.848 rs4955411 chr3:49145304 A/G cg20833759 chr3:49053208 WDR6;DALRD3 0.7 10.75 0.51 2.73e-23 Menarche (age at onset); CRC cis rs1862618 0.853 rs33326 chr5:56142601 G/A cg18230493 chr5:56204884 C5orf35 -0.72 -9.21 -0.45 4.06e-18 Initial pursuit acceleration; CRC cis rs6142102 0.961 rs8119937 chr20:32645551 C/T cg08999081 chr20:33150536 PIGU 0.39 6.11 0.32 2.77e-9 Skin pigmentation; CRC cis rs1005277 0.579 rs1780146 chr10:38517874 C/A cg17219203 chr10:38645113 HSD17B7P2 -0.41 -5.69 -0.3 2.75e-8 Extrinsic epigenetic age acceleration; CRC cis rs12594515 1.000 rs8025258 chr15:45987554 C/A cg19682013 chr15:45996608 NA 0.32 6.7 0.35 9.09e-11 Waist circumference;Weight; CRC trans rs11252926 0.528 rs11252090 chr10:436547 C/T cg00953403 chr17:74099816 EXOC7 -0.48 -7.28 -0.37 2.53e-12 Psychosis in Alzheimer's disease; CRC trans rs17444059 0.925 rs17528473 chr5:58559042 C/T cg01818579 chr20:55982315 RBM38 -0.54 -5.97 -0.31 6.29e-9 Immune response to smallpox vaccine (IL-6); CRC cis rs1862618 0.853 rs860580 chr5:56149429 G/T cg18230493 chr5:56204884 C5orf35 0.72 9.39 0.46 1.05e-18 Initial pursuit acceleration; CRC cis rs34172651 0.876 rs2547033 chr16:24743657 C/T cg00339695 chr16:24857497 SLC5A11 0.26 6.16 0.32 2.14e-9 Intelligence (multi-trait analysis); CRC cis rs8077889 0.672 rs4793028 chr17:41857212 T/C cg25876840 chr17:41920477 NA 0.41 6.46 0.34 3.83e-10 Triglycerides; CRC cis rs514406 0.505 rs856721 chr1:53162156 C/A cg08859206 chr1:53392774 SCP2 -0.41 -6.17 -0.32 1.99e-9 Monocyte count; CRC cis rs2228479 0.850 rs2283565 chr16:89827556 G/T cg19635926 chr16:89946313 TCF25 0.63 5.68 0.3 3.01e-8 Skin colour saturation; CRC cis rs4332037 0.707 rs11763813 chr7:1896690 C/T cg23378565 chr7:2036160 MAD1L1 -0.41 -5.89 -0.31 9.79e-9 Bipolar disorder; CRC cis rs3858526 0.959 rs4758219 chr11:5951846 G/C cg02574844 chr11:5959923 NA -0.46 -6.45 -0.33 4.08e-10 DNA methylation (variation); CRC cis rs9611565 0.694 rs202656 chr22:41842203 T/A cg06634786 chr22:41940651 POLR3H 0.73 8.14 0.41 8.46e-15 Vitiligo; CRC cis rs6714710 0.603 rs2278700 chr2:98427382 T/C cg26665480 chr2:98280029 ACTR1B 0.52 7.18 0.37 4.53e-12 Posterior cortical atrophy and Alzheimer's disease; CRC cis rs6963495 0.745 rs56239334 chr7:105165351 G/A cg02135003 chr7:105160482 PUS7 -0.91 -12.41 -0.56 2.87e-29 Bipolar disorder (body mass index interaction); CRC cis rs5750830 0.621 rs5757665 chr22:39821641 A/G cg25956985 chr22:39795188 MAP3K7IP1 -0.46 -6.5 -0.34 2.96e-10 Intelligence (multi-trait analysis); CRC cis rs1267303 0.642 rs6696219 chr1:47000408 T/C cg08533674 chr1:46993347 NA -0.78 -10.48 -0.5 2.36e-22 Monobrow; CRC cis rs7618915 0.501 rs12635140 chr3:52738165 C/T cg08222913 chr3:52553049 STAB1 0.33 6.14 0.32 2.39e-9 Bipolar disorder; CRC cis rs1564271 1.000 rs1197422 chr10:27012078 A/G cg13837822 chr10:26931731 LOC731789 0.47 6.5 0.34 2.9e-10 Overall survival in serous epithelial ovarian cancer treated with paclitaxel and cisplatin; CRC cis rs6546324 0.625 rs6546325 chr2:67861901 C/A cg15745817 chr2:67799979 NA -0.55 -9.56 -0.47 2.8e-19 Endometriosis; CRC cis rs10504229 1.000 rs60454728 chr8:58173781 G/A cg24829409 chr8:58192753 C8orf71 -0.68 -11.34 -0.53 2.27e-25 Developmental language disorder (linguistic errors); CRC cis rs11098499 0.754 rs17049949 chr4:120255290 A/G cg09307838 chr4:120376055 NA 0.62 9.63 0.47 1.68e-19 Corneal astigmatism; CRC cis rs57221529 0.766 rs4957053 chr5:575927 T/C cg09021430 chr5:549028 NA -0.72 -7.86 -0.4 5.63e-14 Lung disease severity in cystic fibrosis; CRC cis rs11098499 0.739 rs10013032 chr4:120149419 C/T cg09307838 chr4:120376055 NA -0.53 -8.41 -0.42 1.23e-15 Corneal astigmatism; CRC cis rs9323205 0.798 rs2999392 chr14:51655145 A/G cg23942311 chr14:51606299 NA -0.6 -9.08 -0.45 1.04e-17 Cancer; CRC cis rs9326248 0.530 rs1242229 chr11:117062370 A/G cg26566898 chr11:117069891 TAGLN 0.4 5.65 0.3 3.53e-8 Blood protein levels; CRC cis rs7617480 0.648 rs4974088 chr3:48898749 T/C cg07636037 chr3:49044803 WDR6 0.87 10.5 0.5 2e-22 Subjective well-being (multi-trait analysis);Menarche (age at onset); CRC cis rs8060686 0.920 rs73594556 chr16:67925435 G/A cg26727032 chr16:67993705 SLC12A4 -0.58 -7.09 -0.36 8.05e-12 HDL cholesterol;Metabolic syndrome; CRC cis rs2749592 0.550 rs9733309 chr10:37882405 G/A cg25517755 chr10:38738941 LOC399744 0.41 5.91 0.31 8.44e-9 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs875971 1.000 rs10244498 chr7:66116056 A/G cg11764359 chr7:65958608 NA 0.61 9.45 0.46 6.66e-19 Aortic root size; CRC cis rs10876993 0.821 rs1629032 chr12:58038686 C/T cg18357645 chr12:58087776 OS9 0.52 7.0 0.36 1.4e-11 Celiac disease or Rheumatoid arthritis; CRC cis rs9372498 0.536 rs9489450 chr6:118904385 G/A cg18833306 chr6:118973337 C6orf204 0.44 5.64 0.3 3.68e-8 Diastolic blood pressure; CRC cis rs6964587 1.000 rs12537846 chr7:91721581 C/T cg17063962 chr7:91808500 NA -0.77 -13.72 -0.6 3.43e-34 Breast cancer; CRC trans rs11039798 1.000 rs11039978 chr11:48760237 A/G cg03929089 chr4:120376271 NA 0.63 6.06 0.32 3.73e-9 Axial length; CRC cis rs6502050 0.835 rs8070014 chr17:80115247 T/G cg11859384 chr17:80120422 CCDC57 -0.37 -5.98 -0.31 5.86e-9 Life satisfaction; CRC trans rs12495832 0.841 rs76286406 chr3:147898445 T/C cg10221266 chr7:153579447 NA 0.55 6.06 0.32 3.81e-9 Chin dimples; CRC trans rs11764590 0.950 rs11514731 chr7:2051503 C/G cg11693508 chr17:37793320 STARD3 0.62 7.08 0.36 8.79e-12 Neuroticism; CRC cis rs2549003 1.000 rs2549004 chr5:131827825 C/G cg21138405 chr5:131827807 IRF1 -0.59 -11.77 -0.54 6.37e-27 Asthma (sex interaction); CRC cis rs344364 0.529 rs186941 chr16:1930088 T/C cg14074117 chr16:1909714 C16orf73 -0.46 -6.55 -0.34 2.23e-10 Glomerular filtration rate in chronic kidney disease; CRC cis rs12476592 0.714 rs262491 chr2:63841113 A/G cg10828910 chr2:63850056 LOC388955 0.56 6.84 0.35 3.86e-11 Childhood ear infection; CRC cis rs4660531 0.890 rs61229336 chr1:41834935 C/T cg19619003 chr1:41846758 NA -0.38 -5.75 -0.3 2.09e-8 Bipolar disorder; CRC cis rs1580019 0.961 rs2392056 chr7:32498953 T/C cg06627557 chr7:32535165 LSM5;AVL9 0.72 11.27 0.53 3.82e-25 Cognitive ability; CRC cis rs4727027 0.901 rs1534198 chr7:148772323 T/C cg12479418 chr7:148823350 ZNF425;ZNF398 0.44 6.01 0.31 5.06e-9 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC cis rs1150668 0.768 rs1233713 chr6:28198281 A/G cg03623178 chr6:28175578 NA 0.62 9.52 0.46 3.87e-19 Pubertal anthropometrics; CRC cis rs60843830 1.000 rs3791223 chr2:222336 T/C cg25945732 chr2:264204 ACP1;SH3YL1 0.72 11.63 0.54 2.04e-26 Spherical equivalent (joint analysis main effects and education interaction); CRC cis rs9326248 1.000 rs3736120 chr11:117032125 G/T cg15534755 chr11:117069859 TAGLN 0.35 6.78 0.35 5.48e-11 Blood protein levels; CRC cis rs2204008 0.630 rs12306932 chr12:38242029 C/T cg13010199 chr12:38710504 ALG10B -0.41 -5.75 -0.3 2.04e-8 Bladder cancer; CRC cis rs6089584 0.816 rs6061411 chr20:60634716 C/A cg23262073 chr20:60523788 NA -0.47 -7.26 -0.37 2.87e-12 Body mass index; CRC cis rs898097 1.000 rs898097 chr17:80904310 C/T cg17346650 chr17:80929145 B3GNTL1 0.34 5.66 0.3 3.28e-8 Breast cancer; CRC cis rs28386778 0.897 rs2727320 chr17:61865325 T/C cg06601766 chr17:61851465 DDX42;CCDC47 0.46 6.2 0.32 1.66e-9 Prudent dietary pattern; CRC cis rs780096 0.506 rs1262430 chr2:27673798 T/C cg02592271 chr2:27665507 KRTCAP3 -0.29 -6.6 -0.34 1.68e-10 Total body bone mineral density; CRC cis rs651907 0.557 rs11711079 chr3:101386918 G/A cg11279151 chr3:101281821 RG9MTD1 -0.57 -7.74 -0.39 1.25e-13 Colorectal cancer; CRC cis rs910316 0.967 rs175479 chr14:75561871 A/C cg03030879 chr14:75389066 RPS6KL1 0.45 7.17 0.37 5.12e-12 Height; CRC cis rs6952808 0.929 rs34145223 chr7:1926237 G/A cg04267008 chr7:1944627 MAD1L1 -0.82 -12.66 -0.57 3.39e-30 Bipolar disorder and schizophrenia; CRC cis rs7811142 1.000 rs74460138 chr7:100027339 C/G cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.17 17.56 0.7 3.65e-49 Platelet count; CRC cis rs6940638 0.606 rs6456771 chr6:27232395 G/A cg12292205 chr6:26970375 C6orf41 -0.51 -6.46 -0.34 3.85e-10 Intelligence (multi-trait analysis); CRC cis rs11650494 0.710 rs73987294 chr17:47474730 T/C cg08112188 chr17:47440006 ZNF652 0.69 6.28 0.33 1.05e-9 Prostate cancer; CRC cis rs8180040 0.726 rs7610636 chr3:47064436 A/C cg02527881 chr3:46936655 PTH1R 0.39 7.06 0.36 1.02e-11 Colorectal cancer; CRC trans rs3903072 0.528 rs7928652 chr11:65580228 A/C cg17712092 chr4:129076599 LARP1B 0.45 6.13 0.32 2.47e-9 Breast cancer; CRC cis rs2836974 0.583 rs2410124 chr21:40704760 C/G cg06238570 chr21:40685208 BRWD1 -0.78 -11.93 -0.55 1.63e-27 Cognitive function; CRC cis rs8031584 0.678 rs8035703 chr15:31168472 T/C cg08109568 chr15:31115862 NA -0.68 -10.66 -0.51 5.47e-23 Huntington's disease progression; CRC cis rs2073300 0.609 rs6137929 chr20:23376357 G/A cg12062639 chr20:23401060 NAPB 0.74 6.78 0.35 5.43e-11 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs7726839 0.574 rs11134149 chr5:637277 A/G cg16447950 chr5:562315 NA -0.7 -10.02 -0.48 8.41e-21 Obesity-related traits; CRC cis rs4319547 0.728 rs61954974 chr12:123074169 T/C cg05707623 chr12:122985044 ZCCHC8 -0.75 -9.4 -0.46 9.56e-19 Body mass index; CRC cis rs11719291 0.915 rs9834996 chr3:48754877 G/T cg00383909 chr3:49044727 WDR6 0.85 8.57 0.43 4.15e-16 Cognitive function; CRC cis rs929596 0.564 rs2741027 chr2:234518011 G/A cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.43 -5.7 -0.3 2.62e-8 Total bilirubin levels in HIV-1 infection; CRC cis rs3858526 0.642 rs10838783 chr11:5900282 T/G cg02574844 chr11:5959923 NA -0.44 -6.15 -0.32 2.25e-9 DNA methylation (variation); CRC cis rs7737355 0.812 rs4705890 chr5:130855000 A/G cg25547332 chr5:131281432 NA 0.36 5.87 0.31 1.07e-8 Life satisfaction; CRC cis rs1448094 0.512 rs6539931 chr12:86247473 C/T cg25456477 chr12:86230367 RASSF9 0.34 5.99 0.31 5.54e-9 Major depressive disorder; CRC cis rs877282 1.000 rs12775643 chr10:773242 G/A cg17470449 chr10:769945 NA 0.6 8.43 0.42 1.1e-15 Uric acid levels; CRC cis rs28386778 0.897 rs2156903 chr17:61937179 G/A cg11494091 chr17:61959527 GH2 0.59 9.95 0.48 1.51e-20 Prudent dietary pattern; CRC cis rs12950390 0.893 rs11079789 chr17:45849715 A/G cg24803719 chr17:45855879 NA -0.3 -6.5 -0.34 2.98e-10 IgG glycosylation; CRC trans rs10983614 1.000 rs7867776 chr9:120072627 A/G cg05492810 chr11:78129288 GAB2 0.45 6.18 0.32 1.88e-9 Survival in pancreatic cancer; CRC cis rs490234 0.702 rs7864945 chr9:128373469 C/T cg14078157 chr9:128172775 NA -0.41 -6.82 -0.35 4.38e-11 Mean arterial pressure; CRC cis rs9517320 0.515 rs4772099 chr13:99196121 A/C cg07423050 chr13:99094983 FARP1 -0.53 -7.45 -0.38 8.23e-13 Longevity; CRC cis rs9733 0.596 rs12063547 chr1:150674053 G/T cg15448220 chr1:150897856 SETDB1 -0.47 -6.73 -0.35 7.53e-11 Tonsillectomy; CRC cis rs9467603 0.925 rs3949215 chr6:25777497 A/T cg08501292 chr6:25962987 TRIM38 -0.94 -8.19 -0.41 5.94e-15 Intelligence (multi-trait analysis); CRC cis rs6500395 0.962 rs868792 chr16:48640632 T/C cg04672837 chr16:48644449 N4BP1 0.44 6.48 0.34 3.28e-10 Response to tocilizumab in rheumatoid arthritis; CRC cis rs889398 0.741 rs7193038 chr16:69926134 T/G cg00738113 chr16:70207722 CLEC18C -0.34 -5.81 -0.3 1.49e-8 Body mass index; CRC cis rs1046896 1.000 rs1046917 chr17:80685655 A/G cg02711726 chr17:80685570 FN3KRP 0.59 9.33 0.46 1.55e-18 Glycated hemoglobin levels; CRC cis rs902774 0.530 rs11834907 chr12:53350985 C/T cg05393297 chr12:53359155 NA -1.06 -10.23 -0.49 1.6e-21 Prostate cancer; CRC cis rs7043114 0.525 rs10116241 chr9:95240546 T/C cg14631576 chr9:95140430 CENPP -0.31 -5.81 -0.3 1.49e-8 Height; CRC cis rs736408 0.812 rs2270197 chr3:52824095 T/G cg15147215 chr3:52552868 STAB1 -0.54 -7.88 -0.4 4.89e-14 Bipolar disorder; CRC cis rs10493773 0.609 rs3753789 chr1:86174814 T/C cg23216685 chr1:86174607 ZNHIT6 -0.29 -6.84 -0.35 3.77e-11 Urate levels in overweight individuals; CRC cis rs11864453 0.826 rs12708928 chr16:72137227 C/A cg01557791 chr16:72042693 DHODH -0.47 -6.54 -0.34 2.36e-10 Fibrinogen levels; CRC cis rs73200209 0.744 rs17498760 chr12:116636803 C/G cg01776926 chr12:116560359 MED13L -0.61 -7.0 -0.36 1.41e-11 Total body bone mineral density; CRC cis rs4588572 0.644 rs2241566 chr5:77784738 C/T cg11547950 chr5:77652471 NA 0.45 6.44 0.33 4.35e-10 Triglycerides; CRC cis rs11209185 0.509 rs12142271 chr1:68446837 A/G cg22082780 chr1:68452167 NA 0.41 6.17 0.32 2.05e-9 Itch intensity from mosquito bite adjusted by bite size; CRC cis rs9311474 0.607 rs4234633 chr3:52557038 C/T cg07507251 chr3:52567010 NT5DC2 0.48 7.24 0.37 3.17e-12 Electroencephalogram traits; CRC cis rs4808199 1.000 rs60003758 chr19:19557353 A/G cg03709012 chr19:19516395 GATAD2A 1.03 12.44 0.57 2.21e-29 Nonalcoholic fatty liver disease; CRC cis rs11098699 0.821 rs2099955 chr4:124214160 C/T cg09941581 chr4:124220074 SPATA5 0.4 5.78 0.3 1.75e-8 Mosquito bite size; CRC cis rs1448094 0.511 rs56291271 chr12:86162287 G/A cg00310523 chr12:86230176 RASSF9 0.36 5.91 0.31 8.34e-9 Major depressive disorder; CRC cis rs6089584 0.528 rs4925334 chr20:60626769 C/T cg13770153 chr20:60521292 NA -0.44 -6.53 -0.34 2.43e-10 Body mass index; CRC trans rs10875746 0.855 rs10875729 chr12:48426726 A/G cg08231274 chr14:57735852 MUDENG;EXOC5 -0.54 -5.98 -0.31 5.74e-9 Longevity (90 years and older); CRC cis rs916888 0.610 rs199454 chr17:44800110 G/A cg15921436 chr17:44337874 NA -0.48 -6.36 -0.33 6.68e-10 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs10782582 0.569 rs4549990 chr1:76125075 A/G cg03433033 chr1:76189801 ACADM -0.42 -6.1 -0.32 2.94e-9 Daytime sleep phenotypes; CRC cis rs2243480 1.000 rs316317 chr7:65613637 G/T cg25985355 chr7:65971099 NA -0.55 -6.23 -0.32 1.41e-9 Diabetic kidney disease; CRC cis rs9906944 0.564 rs9674544 chr17:47084711 G/A cg10950924 chr17:47092072 IGF2BP1 -0.38 -6.14 -0.32 2.31e-9 Intelligence (multi-trait analysis);Body fat percentage; CRC cis rs35110281 0.626 rs162388 chr21:44936032 G/A cg04455712 chr21:45112962 RRP1B 0.39 7.22 0.37 3.59e-12 Mean corpuscular volume; CRC cis rs2749592 0.531 rs10764134 chr10:37856660 T/C cg25517755 chr10:38738941 LOC399744 0.42 5.98 0.31 5.86e-9 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs2573652 0.755 rs1469830 chr15:100517403 G/T cg00587665 chr15:100533223 ADAMTS17 0.46 7.91 0.4 4.03e-14 Height; CRC trans rs783540 0.867 rs11855735 chr15:83296545 A/T cg18393722 chr15:85113863 UBE2QP1 0.4 7.15 0.37 5.66e-12 Schizophrenia; CRC cis rs2836974 0.965 rs9941894 chr21:40634058 C/T cg17971929 chr21:40555470 PSMG1 0.74 10.29 0.49 1.02e-21 Cognitive function; CRC cis rs7215564 0.730 rs1125587 chr17:78581696 A/G cg09596252 chr17:78655493 RPTOR 0.62 6.47 0.34 3.64e-10 Myopia (pathological); CRC cis rs6732160 0.588 rs72841902 chr2:73372212 T/A cg01422370 chr2:73384389 NA 0.37 5.83 0.31 1.35e-8 Intelligence (multi-trait analysis); CRC cis rs4664293 0.867 rs7579206 chr2:160572503 A/C cg08347373 chr2:160653686 CD302 -0.44 -6.9 -0.36 2.63e-11 Monocyte percentage of white cells; CRC cis rs10924970 0.687 rs4433382 chr1:235364993 C/A cg09010748 chr1:235293032 TOMM20 -0.41 -5.76 -0.3 1.95e-8 Asthma; CRC cis rs644799 0.710 rs473852 chr11:95568757 C/A cg25478527 chr11:95522999 CEP57;FAM76B 0.48 7.36 0.38 1.44e-12 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs1003719 0.715 rs2835640 chr21:38537380 G/A cg10648535 chr21:38446584 PIGP;TTC3 -0.48 -6.67 -0.35 1.08e-10 Eye color traits; CRC cis rs9486715 0.867 rs9480700 chr6:96965056 A/G cg06623918 chr6:96969491 KIAA0776 1.03 20.52 0.75 7.72e-61 Headache; CRC cis rs1448094 0.511 rs61930579 chr12:86157044 G/A cg06740227 chr12:86229804 RASSF9 0.38 5.7 0.3 2.73e-8 Major depressive disorder; CRC cis rs3806843 0.966 rs6579965 chr5:140168811 T/G cg16607685 chr5:140181889 PCDHA2;PCDHA1;PCDHA3 -0.26 -5.92 -0.31 8.09e-9 Depressive symptoms (multi-trait analysis); CRC cis rs17376456 0.825 rs67328989 chr5:93243133 T/A cg25358565 chr5:93447407 FAM172A 1.08 10.84 0.51 1.29e-23 Diabetic retinopathy; CRC trans rs853679 0.546 rs200952 chr6:27836976 C/T cg16898833 chr6:26189333 HIST1H4D 0.72 6.45 0.34 4.08e-10 Depression; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg21536585 chr5:133801528 NA 0.39 6.07 0.32 3.56e-9 Liver disease severity in Alagille syndrome; CRC cis rs13161895 0.941 rs12519642 chr5:179438626 T/G cg02702477 chr5:179499311 RNF130 -0.56 -6.48 -0.34 3.35e-10 LDL cholesterol; CRC cis rs975210 0.556 rs2291986 chr15:70368432 C/T cg01666796 chr15:70364327 TLE3 0.48 5.83 0.31 1.33e-8 Height;Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction);Waist circumference adjusted for BMI in active individuals;Waist circumference adjusted for body mass index; CRC cis rs7209700 0.962 rs56327427 chr17:45354746 C/T cg08085267 chr17:45401833 C17orf57 0.44 6.26 0.33 1.2e-9 IgG glycosylation; CRC trans rs1864729 0.892 rs1821134 chr8:98266824 C/T cg08679828 chr8:102218111 ZNF706 0.62 7.56 0.38 4.04e-13 Estradiol plasma levels (breast cancer); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg18784586 chr12:13044401 GPRC5A 0.43 6.2 0.32 1.71e-9 Response to antipsychotic treatment; CRC trans rs6550704 0.687 rs9865314 chr3:22634337 A/G cg20032723 chr11:126174041 DCPS -0.41 -6.1 -0.32 3.04e-9 Daytime sleep phenotypes; CRC cis rs4713118 0.513 rs149951 chr6:28033087 T/C cg23161317 chr6:28129485 ZNF389 0.45 6.5 0.34 3.01e-10 Parkinson's disease; CRC cis rs9733 0.596 rs3087960 chr1:150620569 C/G cg17724175 chr1:150552817 MCL1 0.59 9.48 0.46 5.17e-19 Tonsillectomy; CRC trans rs9929218 1.000 rs8045022 chr16:68807087 T/C cg04657470 chr2:198365150 HSPE1;HSPD1 -0.82 -11.54 -0.54 4.33e-26 Colorectal cancer; CRC cis rs6681460 1.000 rs7521111 chr1:67121634 T/C cg02459107 chr1:67143332 SGIP1 0.48 8.38 0.42 1.54e-15 Presence of antiphospholipid antibodies; CRC cis rs2274273 0.624 rs8005450 chr14:55799165 A/T cg10130446 chr14:55658398 DLGAP5 -0.41 -5.74 -0.3 2.21e-8 Protein biomarker; CRC trans rs10435719 0.902 rs7459545 chr8:11804389 G/T cg06636001 chr8:8085503 FLJ10661 0.5 7.57 0.39 3.83e-13 C-reactive protein levels or triglyceride levels (pleiotropy); CRC cis rs2153535 0.580 rs2327061 chr6:8447231 G/C cg21535247 chr6:8435926 SLC35B3 0.5 7.56 0.38 4.18e-13 Motion sickness; CRC cis rs12325245 0.536 rs35908812 chr16:58587426 T/C cg19824325 chr16:58548873 SETD6 0.9 6.09 0.32 3.09e-9 Schizophrenia; CRC cis rs1580019 0.844 rs4723159 chr7:32512804 T/C cg06627557 chr7:32535165 LSM5;AVL9 0.85 13.28 0.59 1.6e-32 Cognitive ability; CRC cis rs2245008 0.762 rs168800 chr16:83980391 T/C cg07978099 chr16:83986941 OSGIN1 0.54 6.55 0.34 2.17e-10 Pursuit maintenance gain; CRC cis rs9527 0.590 rs7067663 chr10:104883650 A/G cg04362960 chr10:104952993 NT5C2 0.59 8.22 0.41 4.66e-15 Arsenic metabolism; CRC cis rs10540 1.000 rs12419766 chr11:503710 C/T cg19913688 chr11:428466 ANO9 -0.7 -7.19 -0.37 4.26e-12 Body mass index; CRC cis rs11098499 0.866 rs12499602 chr4:120284387 T/A cg24375607 chr4:120327624 NA 0.48 7.48 0.38 6.72e-13 Corneal astigmatism; CRC cis rs875971 0.862 rs12698521 chr7:65939489 T/C cg11764359 chr7:65958608 NA 0.62 9.91 0.48 1.96e-20 Aortic root size; CRC cis rs8072100 0.790 rs1962307 chr17:45707871 A/G cg08085267 chr17:45401833 C17orf57 -0.53 -8.14 -0.41 8.37e-15 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs4144743 1.000 rs4144743 chr17:45323125 A/G cg18085866 chr17:45331354 ITGB3 -0.54 -7.56 -0.38 4.07e-13 Body mass index; CRC cis rs4713118 0.516 rs7739216 chr6:28079946 G/T cg23161317 chr6:28129485 ZNF389 0.54 6.56 0.34 2.06e-10 Parkinson's disease; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg15492422 chr19:2328553 SPPL2B;LSM7 0.43 6.06 0.32 3.7e-9 Anxiety disorder; CRC cis rs8067545 0.641 rs175922 chr17:19825579 T/C cg04132472 chr17:19861366 AKAP10 0.43 6.66 0.34 1.15e-10 Schizophrenia; CRC cis rs17401966 0.867 rs10492973 chr1:10398985 T/C cg19773385 chr1:10388646 KIF1B -0.67 -10.94 -0.52 5.85e-24 Hepatocellular carcinoma; CRC cis rs305851 0.818 rs1504328 chr6:39753352 G/A cg02386599 chr6:39769542 DAAM2 0.39 6.16 0.32 2.15e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs853679 0.517 rs9380059 chr6:28132358 A/C cg12172441 chr6:28176163 NA 0.64 7.53 0.38 5.03e-13 Depression; CRC cis rs1336900 0.641 rs6587756 chr1:150546865 A/T cg17724175 chr1:150552817 MCL1 -0.68 -11.38 -0.53 1.63e-25 Blood protein levels; CRC cis rs7264396 0.733 rs6058305 chr20:34310757 C/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.64 -10.89 -0.51 8.94e-24 Total cholesterol levels; CRC cis rs6502050 0.835 rs8077772 chr17:80117220 A/G cg13198984 chr17:80129470 CCDC57 -0.42 -7.25 -0.37 2.94e-12 Life satisfaction; CRC cis rs9902453 1.000 rs7207021 chr17:28400516 C/A cg26525008 chr17:28256777 EFCAB5;SSH2 -0.58 -8.75 -0.43 1.12e-16 Coffee consumption (cups per day); CRC cis rs853679 0.607 rs200489 chr6:27798257 T/C cg23259851 chr6:27775964 HIST1H2AI;HIST1H2BL 0.71 5.94 0.31 7.25e-9 Depression; CRC cis rs394563 0.559 rs13219868 chr6:149686518 T/G cg03678062 chr6:149772716 ZC3H12D 0.35 6.41 0.33 5.15e-10 Dupuytren's disease; CRC cis rs11122272 0.701 rs971533 chr1:231522097 T/C cg06096015 chr1:231504339 EGLN1 0.4 5.98 0.31 5.78e-9 Hemoglobin concentration; CRC cis rs4423214 1.000 rs28364617 chr11:71159764 T/G cg05163923 chr11:71159392 DHCR7 0.68 9.8 0.48 4.49e-20 Vitamin D levels; CRC cis rs6952808 0.792 rs4721184 chr7:1950784 T/C cg21782813 chr7:2030301 MAD1L1 0.45 7.61 0.39 2.9e-13 Bipolar disorder and schizophrenia; CRC cis rs10751667 0.643 rs7394436 chr11:970373 G/C cg01483505 chr11:975446 AP2A2 0.46 7.66 0.39 2.11e-13 Alzheimer's disease (late onset); CRC cis rs1348850 0.872 rs4893824 chr2:178298104 G/A cg22681709 chr2:178499509 PDE11A -0.39 -7.02 -0.36 1.25e-11 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg13959152 chr12:100535986 UHRF1BP1L 0.47 6.1 0.32 3e-9 Thyroid stimulating hormone; CRC cis rs9303280 0.559 rs4795408 chr17:38107627 G/A cg24910161 chr17:38119198 GSDMA -0.36 -6.2 -0.32 1.74e-9 Self-reported allergy; CRC cis rs7894051 0.867 rs10466127 chr10:135188519 A/G cg20534287 chr10:135191450 PAOX -0.73 -5.91 -0.31 8.32e-9 Lifespan; CRC cis rs12155623 0.834 rs16939055 chr8:49824013 T/G cg00325661 chr8:49890786 NA 0.37 5.78 0.3 1.77e-8 Sudden cardiac arrest; CRC cis rs7259376 0.967 rs808369 chr19:22474282 C/T cg02657401 chr19:22469223 NA 0.38 8.68 0.43 1.82e-16 Menopause (age at onset); CRC cis rs2836950 0.501 rs2836985 chr21:40701169 A/G cg06238570 chr21:40685208 BRWD1 -0.57 -8.2 -0.41 5.57e-15 Menarche (age at onset); CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg01911186 chr12:12765398 CREBL2 0.5 6.58 0.34 1.88e-10 Thyroid stimulating hormone; CRC trans rs61931739 0.534 rs1490113 chr12:34132394 A/G cg26384229 chr12:38710491 ALG10B 0.52 6.85 0.35 3.62e-11 Morning vs. evening chronotype; CRC cis rs6585424 1.000 rs34749786 chr10:81924390 C/A cg11900509 chr10:81946545 ANXA11 -0.76 -9.32 -0.46 1.78e-18 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs2227564 0.597 rs12256103 chr10:75545251 A/G cg00564723 chr10:75632066 CAMK2G -0.31 -7.45 -0.38 8.41e-13 Crohn's disease;Inflammatory bowel disease; CRC cis rs17443541 0.507 rs10196195 chr2:200456620 C/T cg03741458 chr2:200468445 NA -0.36 -5.69 -0.3 2.77e-8 Intelligence (multi-trait analysis); CRC cis rs55728055 0.661 rs1018488 chr22:31992376 A/G cg01338084 chr22:32026380 PISD 1.1 7.42 0.38 9.96e-13 Age-related hearing impairment; CRC cis rs875971 0.660 rs801192 chr7:66031952 C/G cg00343986 chr7:65444356 GUSB -0.5 -7.43 -0.38 9.64e-13 Aortic root size; CRC cis rs3859192 0.599 rs34342173 chr17:38161507 T/C cg17344932 chr17:38183730 MED24;SNORD124 0.86 16.5 0.67 5.46e-45 White blood cell count; CRC cis rs7617773 0.780 rs13085251 chr3:48340045 C/T cg11946769 chr3:48343235 NME6 0.73 9.93 0.48 1.73e-20 Coronary artery disease; CRC cis rs911555 0.673 rs7144271 chr14:103890674 A/G cg24130564 chr14:104152367 KLC1 -0.45 -6.2 -0.32 1.72e-9 Intelligence (multi-trait analysis); CRC cis rs4285028 0.948 rs34566912 chr3:121679626 G/A cg20356878 chr3:121714668 ILDR1 -0.47 -6.73 -0.35 7.47e-11 Multiple sclerosis; CRC cis rs2204008 0.623 rs1315348 chr12:38163044 G/A cg13010199 chr12:38710504 ALG10B -0.42 -6.06 -0.32 3.74e-9 Bladder cancer; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg03613717 chr10:121356708 TIAL1 0.51 6.59 0.34 1.8e-10 Thyroid stimulating hormone; CRC cis rs1887596 0.705 rs9553874 chr13:27189883 C/T cg01312412 chr13:27282625 NA 0.45 5.93 0.31 7.54e-9 Facial morphology (factor 3, length of philtrum); CRC cis rs9640161 0.711 rs60268791 chr7:150023800 G/T cg12556325 chr7:150026731 C7orf29;LRRC61 -0.38 -5.82 -0.31 1.37e-8 Blood protein levels;Circulating chemerin levels; CRC cis rs9487051 0.714 rs6902892 chr6:109627601 G/T cg21918786 chr6:109611834 NA -0.39 -6.84 -0.35 3.78e-11 Reticulocyte fraction of red cells; CRC cis rs9434723 0.920 rs2239560 chr1:9304731 C/T cg04199779 chr1:9294473 H6PD 0.48 5.75 0.3 2.04e-8 Height; CRC cis rs6540559 0.673 rs6540564 chr1:210019910 T/C cg22029157 chr1:209979665 IRF6 0.67 7.69 0.39 1.77e-13 Cleft lip with or without cleft palate; CRC cis rs2658782 0.694 rs3019221 chr11:93079700 C/G cg15737290 chr11:93063684 CCDC67 0.5 7.21 0.37 3.95e-12 Pulmonary function decline; CRC cis rs7904368 0.707 rs12253979 chr10:16853415 T/C cg14835575 chr10:16859367 RSU1 0.43 5.71 0.3 2.47e-8 Ratio of the peak velocity of the mitral E-Wave divided by the peak velocity of the mitral A-wave.; CRC cis rs8180040 1.000 rs2302278 chr3:47361082 G/T cg02527881 chr3:46936655 PTH1R 0.39 7.31 0.37 2.07e-12 Colorectal cancer; CRC cis rs4631830 0.863 rs2249986 chr10:51521684 T/G cg20129853 chr10:51489980 NA -0.35 -5.69 -0.3 2.77e-8 Prostate-specific antigen levels; CRC cis rs7772486 0.558 rs62435775 chr6:146136415 G/C cg23711669 chr6:146136114 FBXO30 0.65 9.61 0.47 1.95e-19 Lobe attachment (rater-scored or self-reported); CRC cis rs2898681 0.581 rs730246 chr4:53680719 T/C cg00338735 chr4:53728038 RASL11B 0.38 5.87 0.31 1.06e-8 Optic nerve measurement (cup area); CRC cis rs780096 0.546 rs2911712 chr2:27626945 A/T cg22903471 chr2:27725779 GCKR -0.38 -6.24 -0.33 1.37e-9 Total body bone mineral density; CRC trans rs9291683 0.588 rs2240721 chr4:10020564 G/A cg26043149 chr18:55253948 FECH 0.51 7.92 0.4 3.79e-14 Bone mineral density; CRC trans rs7613875 0.537 rs6446195 chr3:50070853 A/G cg21659725 chr3:3221576 CRBN -0.44 -6.5 -0.34 3.03e-10 Body mass index; CRC cis rs6496667 0.738 rs58438191 chr15:91045751 G/A cg04176472 chr15:90893244 GABARAPL3 0.56 7.99 0.4 2.3e-14 Rheumatoid arthritis; CRC trans rs1814175 0.817 rs1615305 chr11:49895222 T/A cg11707556 chr5:10655725 ANKRD33B -0.44 -8.43 -0.42 1.12e-15 Height; CRC trans rs1814175 0.618 rs1851843 chr11:50021846 T/C cg11707556 chr5:10655725 ANKRD33B -0.52 -10.25 -0.49 1.36e-21 Height; CRC cis rs4862750 0.872 rs6830426 chr4:187897270 T/A cg22105103 chr4:187893119 NA 0.63 11.52 0.54 4.85e-26 Lobe attachment (rater-scored or self-reported); CRC cis rs12586317 0.620 rs8020370 chr14:35581432 G/A cg16230307 chr14:35515116 FAM177A1 0.78 9.62 0.47 1.82e-19 Psoriasis; CRC cis rs780096 0.546 rs7563162 chr2:27631191 C/T cg27432699 chr2:27873401 GPN1 -0.51 -7.82 -0.4 7.41e-14 Total body bone mineral density; CRC cis rs9398803 0.830 rs1159619 chr6:126801144 C/A cg19875578 chr6:126661172 C6orf173 0.42 5.84 0.31 1.26e-8 Male-pattern baldness; CRC cis rs16975963 0.644 rs111319455 chr19:38162647 A/C cg15135657 chr19:38346511 NA -0.47 -6.56 -0.34 2.15e-10 Longevity; CRC cis rs1552244 0.882 rs6796419 chr3:10040812 G/A cg08888203 chr3:10149979 C3orf24 0.6 8.47 0.42 8.55e-16 Alzheimer's disease; CRC cis rs1552244 0.554 rs3732964 chr3:10048839 C/G cg13047869 chr3:10149882 C3orf24 0.39 5.95 0.31 6.8e-9 Alzheimer's disease; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg08924777 chr16:48278166 LONP2 0.43 6.22 0.32 1.55e-9 Intelligence (multi-trait analysis); CRC cis rs875971 0.660 rs2191268 chr7:66110224 C/T cg18876405 chr7:65276391 NA 0.43 7.76 0.39 1.08e-13 Aortic root size; CRC cis rs7769051 0.522 rs3736725 chr6:133095172 A/G cg07930552 chr6:133119739 C6orf192 0.78 7.8 0.39 8.44e-14 Type 2 diabetes nephropathy; CRC cis rs7949030 0.688 rs11231155 chr11:62365619 A/G cg13298116 chr11:62369859 EML3;MTA2 0.59 10.54 0.5 1.4e-22 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; CRC trans rs3780486 0.846 rs73484568 chr9:33132492 G/A cg04842962 chr6:43655489 MRPS18A 1.16 25.97 0.82 1.16e-81 IgG glycosylation; CRC cis rs67311347 0.955 rs12487955 chr3:40412853 T/C cg24209194 chr3:40518798 ZNF619 0.38 5.69 0.3 2.89e-8 Renal cell carcinoma; CRC cis rs7089973 0.604 rs2420069 chr10:116605103 A/G cg23260525 chr10:116636907 FAM160B1 0.35 8.11 0.41 1.04e-14 Bipolar disorder or attention deficit hyperactivity disorder; CRC cis rs501120 0.564 rs1626459 chr10:44691548 T/C cg09554077 chr10:44749378 NA 0.58 8.13 0.41 8.75e-15 Coronary artery disease;Coronary heart disease; CRC cis rs7572644 0.699 rs12465000 chr2:28199424 G/A cg27432699 chr2:27873401 GPN1 -0.4 -5.61 -0.3 4.22e-8 Response to carboplatin and paclitaxel in ovarian cancer (Caspase 3/7 EC50); CRC cis rs910316 1.000 rs4899544 chr14:75546556 C/T cg03030879 chr14:75389066 RPS6KL1 -0.46 -7.27 -0.37 2.64e-12 Height; CRC cis rs7618915 0.501 rs2164885 chr3:52731269 T/C cg18099408 chr3:52552593 STAB1 -0.46 -7.66 -0.39 2.06e-13 Bipolar disorder; CRC cis rs2153535 0.541 rs6908504 chr6:8456778 A/G cg21535247 chr6:8435926 SLC35B3 0.51 7.9 0.4 4.36e-14 Motion sickness; CRC cis rs4268898 0.662 rs59996104 chr2:24404064 C/T cg06627628 chr2:24431161 ITSN2 -0.86 -11.71 -0.54 1.02e-26 Asthma; CRC cis rs11690935 0.632 rs34531723 chr2:172564094 A/C cg13550731 chr2:172543902 DYNC1I2 0.68 10.24 0.49 1.57e-21 Schizophrenia; CRC cis rs7618915 0.547 rs12496634 chr3:52709259 A/C cg11645453 chr3:52864694 ITIH4 0.35 6.14 0.32 2.31e-9 Bipolar disorder; CRC cis rs7072216 0.727 rs7901577 chr10:100164442 A/G cg26618903 chr10:100175079 PYROXD2 -0.49 -7.97 -0.4 2.68e-14 Metabolite levels; CRC cis rs2463822 1.000 rs2513076 chr11:62103711 A/G cg06239285 chr11:62104954 ASRGL1 0.98 11.64 0.54 1.87e-26 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs7584330 0.554 rs7558685 chr2:238434943 A/G cg14458575 chr2:238380390 NA 0.52 6.86 0.35 3.51e-11 Prostate cancer; CRC cis rs2304069 0.526 rs6863283 chr5:149402448 C/A cg22760475 chr5:149380129 HMGXB3;TIGD6 0.46 6.73 0.35 7.57e-11 HIV-1 control; CRC cis rs77686669 1 rs77686669 chr7:99744572 T/C cg19337854 chr7:99768885 GPC2 0.39 5.81 0.31 1.46e-8 Venous thromboembolism adjusted for sickle cell variant rs77121243-T; CRC cis rs8060686 0.920 rs16942887 chr16:67928042 G/A cg04539111 chr16:67997858 SLC12A4 -0.48 -5.81 -0.31 1.47e-8 HDL cholesterol;Metabolic syndrome; CRC cis rs4563143 0.647 rs34218744 chr19:29256821 A/T cg14983838 chr19:29218262 NA 0.47 6.82 0.35 4.42e-11 Methadone dose in opioid dependence; CRC trans rs2243480 1.000 rs316326 chr7:65609453 T/C cg10756647 chr7:56101905 PSPH 0.74 7.72 0.39 1.37e-13 Diabetic kidney disease; CRC cis rs908922 0.628 rs488393 chr1:152489548 C/T cg09873164 chr1:152488093 CRCT1 0.37 6.15 0.32 2.21e-9 Hair morphology; CRC cis rs6743376 0.556 rs1800930 chr2:113820530 A/G cg09040174 chr2:113837401 NA 0.4 5.84 0.31 1.22e-8 Inflammatory biomarkers; CRC cis rs17209837 0.607 rs45560338 chr7:87111106 T/C cg00919237 chr7:87102261 ABCB4 -0.51 -6.7 -0.35 9.12e-11 Gallbladder cancer; CRC trans rs877282 1.000 rs877282 chr10:771532 G/A cg22713356 chr15:30763199 NA 1.29 16.27 0.67 4.48e-44 Uric acid levels; CRC cis rs1568889 0.877 rs1384903 chr11:28124359 A/T cg06544937 chr11:28130018 METT5D1;KIF18A 0.69 7.82 0.4 7.3e-14 Bipolar disorder; CRC trans rs2727020 0.521 rs7126835 chr11:49594658 T/C cg11707556 chr5:10655725 ANKRD33B -0.48 -7.93 -0.4 3.49e-14 Coronary artery disease; CRC cis rs758324 0.853 rs6882899 chr5:131172467 G/C cg06307176 chr5:131281290 NA 0.43 6.4 0.33 5.5e-10 Alzheimer's disease in APOE e4- carriers; CRC cis rs6502050 0.835 rs10163483 chr17:80110396 C/A cg19223190 chr17:80058835 NA 0.4 6.36 0.33 6.88e-10 Life satisfaction; CRC cis rs2014572 0.967 rs7248000 chr19:57762139 C/T cg12963866 chr19:57752005 ZNF805 -0.39 -5.84 -0.31 1.23e-8 Hyperactive-impulsive symptoms; CRC cis rs2739330 0.828 rs4822454 chr22:24255208 G/A cg23131131 chr22:24373011 LOC391322 -0.63 -9.83 -0.48 3.69e-20 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs6951245 1.000 rs78628466 chr7:1068453 G/C cg22907277 chr7:1156413 C7orf50 0.71 7.39 0.38 1.26e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs875971 0.830 rs6976714 chr7:65891461 G/A cg18876405 chr7:65276391 NA 0.52 8.41 0.42 1.3e-15 Aortic root size; CRC cis rs473651 0.935 rs541128 chr2:239336449 A/G cg08773314 chr2:239334832 ASB1 0.38 8.86 0.44 5.17e-17 Multiple system atrophy; CRC trans rs11105468 1.000 rs11105442 chr12:90260348 G/C cg23572944 chr11:60720130 SLC15A3 -0.45 -6.33 -0.33 7.82e-10 Febrile seizures;Febrile seizures (MMR vaccine-related);Febrile seizures (MMR vaccine-unrelated); CRC cis rs853679 0.550 rs1233699 chr6:28169158 A/T cg15786705 chr6:28176104 NA 0.81 11.64 0.54 1.84e-26 Depression; CRC cis rs4604732 0.631 rs80319072 chr1:247626835 G/A cg02104434 chr1:247694406 LOC148824;OR2C3 0.6 8.82 0.44 6.67e-17 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CRC cis rs7605827 0.930 rs10207209 chr2:15512701 A/G cg19274914 chr2:15703543 NA 0.39 5.76 0.3 1.89e-8 Educational attainment (years of education); CRC cis rs1577917 0.839 rs12216103 chr6:86571128 T/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.44 -5.78 -0.3 1.75e-8 Response to antipsychotic treatment; CRC cis rs4363385 0.818 rs4845514 chr1:153000820 T/C cg25856811 chr1:152973957 SPRR3 -0.26 -7.18 -0.37 4.78e-12 Inflammatory skin disease; CRC cis rs1178968 1.000 rs7802062 chr7:72757812 T/C cg25889504 chr7:72793014 NA 0.53 5.93 0.31 7.73e-9 Triglyceride levels; CRC cis rs9462027 0.562 rs2814946 chr6:34651180 T/C cg07306190 chr6:34760872 UHRF1BP1 -0.35 -6.25 -0.33 1.29e-9 Systemic lupus erythematosus; CRC cis rs72634258 0.786 rs6682709 chr1:8173796 A/C cg00042356 chr1:8021962 PARK7 -0.5 -5.84 -0.31 1.25e-8 Inflammatory bowel disease; CRC cis rs2645694 0.626 rs2703115 chr4:77824442 C/T cg03477792 chr4:77819574 ANKRD56 0.46 6.73 0.35 7.35e-11 Emphysema distribution in smoking; CRC cis rs4144743 0.877 rs7218773 chr17:45324211 C/T cg18085866 chr17:45331354 ITGB3 -0.59 -8.11 -0.41 1.02e-14 Body mass index; CRC cis rs9649213 0.574 rs7802560 chr7:97903806 A/G cg00277769 chr7:97922759 BAIAP2L1 0.62 11.34 0.53 2.29e-25 Prostate cancer (SNP x SNP interaction); CRC cis rs72634258 0.945 rs34157438 chr1:8023586 C/T cg26816564 chr1:7831052 VAMP3 0.56 6.08 0.32 3.35e-9 Inflammatory bowel disease; CRC cis rs798502 0.522 rs7790322 chr7:2830498 C/T cg13628971 chr7:2884303 GNA12 0.4 5.74 0.3 2.12e-8 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Inflammatory bowel disease;Waist circumference adjusted for BMI in non-smokers;Ulcerative colitis;Waist circumference adjusted for body mass index;Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction); CRC cis rs3126085 0.935 rs1552993 chr1:152171483 A/G cg09127314 chr1:152161683 NA 0.53 6.87 0.35 3.25e-11 Atopic dermatitis; CRC cis rs7666738 0.830 rs3846445 chr4:99032939 T/A cg17366294 chr4:99064904 C4orf37 0.44 7.48 0.38 6.96e-13 Colonoscopy-negative controls vs population controls; CRC cis rs11105298 0.786 rs10858897 chr12:89922032 C/A cg00757033 chr12:89920650 WDR51B 0.36 6.03 0.32 4.51e-9 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; CRC cis rs6558530 0.626 rs6558524 chr8:1702512 T/G cg19131313 chr8:1704013 NA -0.49 -6.08 -0.32 3.42e-9 Systolic blood pressure; CRC cis rs4731207 0.570 rs1600738 chr7:124639549 G/T cg23710748 chr7:124431027 NA -0.39 -6.2 -0.32 1.68e-9 Cutaneous malignant melanoma; CRC cis rs3015497 0.752 rs6572682 chr14:51144800 A/T cg09863266 chr14:51125203 SAV1 -0.33 -6.23 -0.32 1.44e-9 Mean platelet volume; CRC cis rs2976388 0.669 rs2976391 chr8:143762724 C/A cg24046110 chr8:143859143 LYNX1 0.4 6.83 0.35 4.19e-11 Urinary tract infection frequency; CRC cis rs8005677 1.000 rs8005677 chr14:23376678 T/C cg01529538 chr14:23388837 RBM23 0.39 6.19 0.32 1.78e-9 Cognitive ability (multi-trait analysis); CRC cis rs2204008 0.619 rs8189576 chr12:38307275 G/A cg26384229 chr12:38710491 ALG10B -0.53 -7.69 -0.39 1.69e-13 Bladder cancer; CRC cis rs7666738 0.649 rs28865589 chr4:98954279 C/A cg05340658 chr4:99064831 C4orf37 0.6 9.37 0.46 1.17e-18 Colonoscopy-negative controls vs population controls; CRC trans rs1814175 0.791 rs10219223 chr11:49791468 A/T cg21153622 chr11:89784906 NA -0.38 -6.09 -0.32 3.2e-9 Height; CRC cis rs4713118 0.513 rs149944 chr6:28002818 C/T cg25164649 chr6:28176230 NA 0.6 8.89 0.44 4.25e-17 Parkinson's disease; CRC cis rs7666738 0.791 rs7665273 chr4:98997413 C/A cg05340658 chr4:99064831 C4orf37 0.61 9.6 0.47 2.07e-19 Colonoscopy-negative controls vs population controls; CRC cis rs875971 0.964 rs9691480 chr7:65944306 A/C cg00343986 chr7:65444356 GUSB 0.43 6.29 0.33 1.03e-9 Aortic root size; CRC cis rs12142240 0.698 rs7525309 chr1:46809025 G/T cg14993813 chr1:46806288 NSUN4 -0.49 -6.22 -0.32 1.5e-9 Menopause (age at onset); CRC cis rs2836974 0.796 rs77153312 chr21:40695499 G/A cg06238570 chr21:40685208 BRWD1 0.76 10.29 0.49 9.94e-22 Cognitive function; CRC cis rs34172651 0.917 rs12599173 chr16:24823619 T/C cg06505273 chr16:24850292 NA 0.39 5.97 0.31 6.27e-9 Intelligence (multi-trait analysis); CRC cis rs6121246 0.909 rs7354225 chr20:30296881 C/T cg13852791 chr20:30311386 BCL2L1 0.63 9.23 0.45 3.29e-18 Mean corpuscular hemoglobin; CRC cis rs7666738 0.830 rs2865979 chr4:99027137 T/C cg17366294 chr4:99064904 C4orf37 0.44 7.48 0.38 6.96e-13 Colonoscopy-negative controls vs population controls; CRC cis rs2108225 0.872 rs2051954 chr7:107441097 G/C cg18560240 chr7:107437656 SLC26A3 -0.64 -9.62 -0.47 1.82e-19 Ulcerative colitis; CRC cis rs4631830 0.900 rs9787697 chr10:51533376 C/T cg20129853 chr10:51489980 NA -0.35 -5.73 -0.3 2.26e-8 Prostate-specific antigen levels; CRC cis rs9660180 0.868 rs12567685 chr1:1806647 T/C cg17747265 chr1:1875780 NA -0.77 -13.6 -0.6 1e-33 Body mass index; CRC cis rs758324 0.947 rs2896961 chr5:131165006 C/T cg25547332 chr5:131281432 NA 0.4 6.1 0.32 3e-9 Alzheimer's disease in APOE e4- carriers; CRC cis rs17401966 0.931 rs61778401 chr1:10426474 G/A cg19773385 chr1:10388646 KIF1B -0.68 -10.98 -0.52 4.16e-24 Hepatocellular carcinoma; CRC cis rs6952808 0.636 rs6964522 chr7:1953523 C/T cg00106254 chr7:1943704 MAD1L1 -0.37 -5.75 -0.3 1.99e-8 Bipolar disorder and schizophrenia; CRC cis rs9463078 0.625 rs12190136 chr6:44767072 A/G cg25276700 chr6:44698697 NA -0.26 -6.39 -0.33 5.82e-10 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; CRC cis rs4713118 0.513 rs149941 chr6:28001033 T/C cg23161317 chr6:28129485 ZNF389 0.45 6.5 0.34 3.05e-10 Parkinson's disease; CRC cis rs10504229 0.562 rs2014516 chr8:58128288 C/A cg02725872 chr8:58115012 NA -0.64 -11.55 -0.54 3.85e-26 Developmental language disorder (linguistic errors); CRC cis rs294883 0.739 rs962338 chr6:159729355 G/A cg14500486 chr6:159655392 FNDC1 -0.36 -6.19 -0.32 1.81e-9 Coronary artery disease; CRC cis rs6479527 0.840 rs7033481 chr9:96752329 A/C cg14459158 chr9:96720562 NA 0.41 7.64 0.39 2.36e-13 Esophageal adenocarcinoma; CRC trans rs6015450 1.000 rs78872658 chr20:57754390 G/A cg22122715 chr13:96086023 CLDN10 -0.55 -6.16 -0.32 2.11e-9 Diastolic blood pressure;Systolic blood pressure;Hypertension;Blood pressure; CRC cis rs3857067 0.806 rs6825522 chr4:95108140 G/T cg11021082 chr4:95130006 SMARCAD1 -0.5 -7.82 -0.4 7.01e-14 QT interval; CRC cis rs9916302 0.904 rs35335692 chr17:37710006 A/G cg03013999 chr17:37608204 MED1 0.47 7.35 0.38 1.58e-12 Glomerular filtration rate (creatinine); CRC cis rs9309473 0.607 rs10198301 chr2:73581600 T/A cg20560298 chr2:73613845 ALMS1 -0.47 -6.44 -0.33 4.29e-10 Metabolite levels; CRC cis rs6598955 0.515 rs61776655 chr1:26541430 T/C cg00852783 chr1:26633632 UBXN11 0.46 7.45 0.38 8.3e-13 Obesity-related traits; CRC trans rs1728785 0.688 rs7203363 chr16:68587692 T/A cg04657470 chr2:198365150 HSPE1;HSPD1 0.58 7.05 0.36 1.08e-11 Ulcerative colitis; CRC cis rs7927592 0.913 rs7102898 chr11:68328870 G/A cg01657329 chr11:68192670 LRP5 -0.47 -6.73 -0.35 7.35e-11 Total body bone mineral density; CRC cis rs7680126 0.586 rs7689060 chr4:10305463 C/G cg00071950 chr4:10020882 SLC2A9 0.45 6.33 0.33 8.07e-10 Urate levels in lean individuals;Urate levels in overweight individuals;Urate levels in obese individuals; CRC cis rs9486719 1.000 rs12201449 chr6:96959382 C/T cg06623918 chr6:96969491 KIAA0776 -0.8 -9.28 -0.46 2.39e-18 Migraine;Coronary artery disease; CRC cis rs8072100 0.782 rs28507314 chr17:45551402 C/T cg08085267 chr17:45401833 C17orf57 -0.62 -10.0 -0.48 9.83e-21 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs7727544 0.904 rs7736102 chr5:131604257 G/A cg12564285 chr5:131593104 PDLIM4 0.38 7.44 0.38 8.91e-13 Blood metabolite levels; CRC cis rs2304069 0.913 rs9324637 chr5:149390947 T/C cg22760475 chr5:149380129 HMGXB3;TIGD6 0.89 10.1 0.49 4.65e-21 HIV-1 control; CRC cis rs2120019 1.000 rs2083731 chr15:75368538 A/C cg11632617 chr15:75315747 PPCDC -0.56 -8.05 -0.41 1.57e-14 Blood trace element (Zn levels); CRC cis rs7726839 0.507 rs56282020 chr5:596701 T/C cg14541582 chr5:601475 NA -0.36 -7.37 -0.38 1.42e-12 Obesity-related traits; CRC cis rs11155671 0.530 rs7758033 chr6:150208135 T/C cg13206674 chr6:150067644 NUP43 0.46 6.58 0.34 1.85e-10 Testicular germ cell tumor; CRC cis rs7605827 0.930 rs7568678 chr2:15596203 C/T cg19274914 chr2:15703543 NA 0.39 5.76 0.3 1.97e-8 Educational attainment (years of education); CRC cis rs6502050 0.799 rs8069827 chr17:80089168 C/T cg09264619 chr17:80180166 NA -0.36 -6.09 -0.32 3.09e-9 Life satisfaction; CRC cis rs9517320 1.000 rs9513430 chr13:99127252 C/G cg07423050 chr13:99094983 FARP1 0.4 6.45 0.34 3.9e-10 Longevity; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg22468868 chr17:58042029 RNFT1 0.43 6.5 0.34 3e-10 Intelligence (multi-trait analysis); CRC cis rs244731 1.000 rs244731 chr5:176539679 C/T cg17509989 chr5:176798049 RGS14 0.64 8.65 0.43 2.28e-16 Urate levels in lean individuals; CRC trans rs116095464 0.558 rs6866776 chr5:264495 C/T cg00938859 chr5:1591904 SDHAP3 0.73 7.89 0.4 4.53e-14 Breast cancer; CRC cis rs10504229 1.000 rs56344560 chr8:58180626 C/G cg02290350 chr8:58132656 NA -0.42 -6.03 -0.32 4.52e-9 Developmental language disorder (linguistic errors); CRC cis rs9467711 0.720 rs9348716 chr6:26375658 G/A cg16898833 chr6:26189333 HIST1H4D 0.74 6.18 0.32 1.94e-9 Autism spectrum disorder or schizophrenia; CRC cis rs2976388 0.507 rs7813604 chr8:143838062 G/A cg12516270 chr8:143859308 LYNX1 0.56 9.86 0.48 3.01e-20 Urinary tract infection frequency; CRC cis rs875971 0.862 rs7796162 chr7:65745758 T/C cg00343986 chr7:65444356 GUSB -0.45 -6.26 -0.33 1.23e-9 Aortic root size; CRC cis rs35146811 0.700 rs7788301 chr7:99782753 C/G cg00553149 chr7:99775558 STAG3;GPC2 0.24 5.9 0.31 8.81e-9 Coronary artery disease; CRC cis rs6951245 1.000 rs11766526 chr7:1101433 G/A cg20603222 chr7:1096387 C7orf50;GPR146 -0.72 -8.66 -0.43 2.19e-16 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs875971 0.638 rs3898855 chr7:66036398 G/C cg18876405 chr7:65276391 NA -0.6 -10.83 -0.51 1.4e-23 Aortic root size; CRC cis rs12586317 0.547 rs12435454 chr14:35466997 A/G cg16230307 chr14:35515116 FAM177A1 0.85 10.08 0.49 5.15e-21 Psoriasis; CRC cis rs9372498 0.764 rs9489371 chr6:118725368 T/C cg18833306 chr6:118973337 C6orf204 0.47 5.86 0.31 1.11e-8 Diastolic blood pressure; CRC cis rs4727027 0.704 rs12535115 chr7:148895087 C/T cg23583168 chr7:148888333 NA -0.93 -17.87 -0.7 2.11e-50 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC cis rs2213920 0.516 rs35976675 chr9:118173444 T/C cg13918206 chr9:118159781 DEC1 -0.81 -7.58 -0.39 3.47e-13 Docetaxel-induced peripheral neuropathy in metastatic castrate-resistant prostate cancer; CRC cis rs2153535 0.580 rs6597318 chr6:8437289 G/A cg21535247 chr6:8435926 SLC35B3 0.48 7.41 0.38 1.1e-12 Motion sickness; CRC cis rs6952808 0.825 rs12669937 chr7:1939765 C/T cg22963979 chr7:1858916 MAD1L1 -0.51 -7.61 -0.39 2.9e-13 Bipolar disorder and schizophrenia; CRC cis rs12594515 1.000 rs6493168 chr15:45986811 A/C cg22117107 chr15:45993392 NA -0.44 -9.02 -0.45 1.58e-17 Waist circumference;Weight; CRC cis rs4285028 0.948 rs34696871 chr3:121671880 T/G cg11130432 chr3:121712080 ILDR1 -0.51 -6.65 -0.34 1.19e-10 Multiple sclerosis; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg13622657 chr9:34620508 DCTN3 0.5 7.17 0.37 5.09e-12 Response to antipsychotic treatment; CRC trans rs2303319 0.504 rs62189053 chr2:162624324 G/A cg09481857 chr22:21368659 P2RX6;MGC16703 -0.64 -6.28 -0.33 1.08e-9 Cognitive function; CRC cis rs55823223 0.503 rs55699990 chr17:73859186 A/G cg08125733 chr17:73851984 WBP2 0.72 9.09 0.45 9.41e-18 Psoriasis; CRC cis rs9322193 0.926 rs9766562 chr6:150109845 C/G cg07701084 chr6:150067640 NUP43 0.46 6.46 0.34 3.77e-10 Lung cancer; CRC cis rs908922 0.676 rs525960 chr1:152497866 T/A cg09873164 chr1:152488093 CRCT1 0.37 6.22 0.32 1.49e-9 Hair morphology; CRC cis rs704795 0.805 rs1728926 chr2:27612937 A/G cg02592271 chr2:27665507 KRTCAP3 -0.26 -5.98 -0.31 5.78e-9 Menopause (age at onset); CRC cis rs10971721 0.643 rs41315997 chr9:33798838 T/C cg13495928 chr9:33750294 PRSS3 0.63 5.65 0.3 3.53e-8 Body mass index; CRC cis rs11122272 0.735 rs2486741 chr1:231516450 G/C cg06096015 chr1:231504339 EGLN1 0.4 5.94 0.31 7.17e-9 Hemoglobin concentration; CRC cis rs798554 0.797 rs798491 chr7:2800521 A/G cg19346786 chr7:2764209 NA -0.44 -7.41 -0.38 1.07e-12 Height; CRC cis rs4268898 0.697 rs10445892 chr2:24406958 T/C cg06627628 chr2:24431161 ITSN2 0.47 6.97 0.36 1.75e-11 Asthma; CRC cis rs7917772 0.636 rs7079231 chr10:104527341 A/G cg11453585 chr10:104263688 ACTR1A;SUFU 0.67 10.02 0.48 8.56e-21 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC cis rs3789045 1.000 rs3789044 chr1:204589101 C/T cg17419461 chr1:204415978 PIK3C2B -0.49 -7.0 -0.36 1.45e-11 Educational attainment (college completion); CRC trans rs8002861 0.905 rs12853286 chr13:44446817 A/G cg12856521 chr11:46389249 DGKZ -0.41 -6.53 -0.34 2.56e-10 Leprosy; CRC cis rs801193 1.000 rs2707845 chr7:66198798 C/T cg11764359 chr7:65958608 NA 0.54 8.26 0.41 3.49e-15 Aortic root size; CRC cis rs875971 0.862 rs880166 chr7:65670762 T/C cg18252515 chr7:66147081 NA 0.39 5.7 0.3 2.72e-8 Aortic root size; CRC cis rs6840360 0.642 rs4696092 chr4:152412603 T/C cg09659197 chr4:152720779 NA 0.33 6.52 0.34 2.63e-10 Intelligence (multi-trait analysis); CRC cis rs55788414 0.932 rs35424543 chr16:81181983 G/A cg06400318 chr16:81190750 PKD1L2 -0.69 -6.72 -0.35 8.13e-11 Left ventricular obstructive tract defect (maternal effect); CRC cis rs514406 0.929 rs1242224 chr1:53314887 G/A cg25767906 chr1:53392781 SCP2 -0.45 -7.33 -0.37 1.75e-12 Monocyte count; CRC cis rs28386778 0.897 rs2236737 chr17:61938100 C/T cg23090583 chr17:61904693 PSMC5;FTSJ3 1.03 20.12 0.74 2.81e-59 Prudent dietary pattern; CRC cis rs1799949 1.000 rs16942 chr17:41244000 T/C cg25072359 chr17:41440525 NA 0.46 6.93 0.36 2.27e-11 Menopause (age at onset); CRC trans rs10983614 1.000 rs7867776 chr9:120072627 A/G cg01708711 chr7:75959031 YWHAG 0.45 6.16 0.32 2.18e-9 Survival in pancreatic cancer; CRC cis rs9304742 0.611 rs10415443 chr19:53464864 C/G cg09915433 chr19:53449742 NA -0.43 -6.0 -0.31 5.1e-9 Psoriasis; CRC cis rs6921919 0.583 rs4357130 chr6:28367683 T/G cg21251018 chr6:28226885 NKAPL 0.39 5.81 0.31 1.48e-8 Autism spectrum disorder or schizophrenia; CRC cis rs3026101 0.671 rs58832024 chr17:5306536 G/T cg25236894 chr17:5323110 RPAIN;NUP88 0.42 6.9 0.36 2.74e-11 Body mass index; CRC cis rs35883536 1.000 rs9803842 chr1:101134877 G/T cg14515779 chr1:101123966 NA -0.43 -8.33 -0.42 2.17e-15 Monocyte count; CRC cis rs6860806 0.507 rs272882 chr5:131669161 G/T cg24060327 chr5:131705240 SLC22A5 -0.51 -7.62 -0.39 2.67e-13 Breast cancer; CRC cis rs9517320 0.515 rs9556972 chr13:99209815 C/T cg20487152 chr13:99095054 FARP1 -0.45 -6.55 -0.34 2.2e-10 Longevity; CRC trans rs11098499 0.754 rs1511017 chr4:120250805 G/A cg25214090 chr10:38739885 LOC399744 0.53 8.36 0.42 1.81e-15 Corneal astigmatism; CRC cis rs11190604 1.000 rs79831012 chr10:102237059 T/C cg16342193 chr10:102329863 NA -0.36 -5.84 -0.31 1.25e-8 Palmitoleic acid (16:1n-7) levels; CRC cis rs1799949 0.683 rs55737636 chr17:41264739 C/T cg19454999 chr17:41278357 BRCA1;NBR2 0.43 6.6 0.34 1.64e-10 Menopause (age at onset); CRC cis rs780096 0.526 rs1647276 chr2:27688601 C/T cg17158414 chr2:27665306 KRTCAP3 -0.3 -6.68 -0.35 9.98e-11 Total body bone mineral density; CRC cis rs7998202 0.614 rs282573 chr13:113362105 G/A cg02820901 chr13:113351484 ATP11A 0.62 6.77 0.35 5.83e-11 Glycated hemoglobin levels; CRC cis rs4481887 1.000 rs4457616 chr1:248492198 A/G cg13385794 chr1:248469461 NA 0.4 6.83 0.35 4.13e-11 Common traits (Other); CRC cis rs7618915 0.547 rs62255371 chr3:52747321 A/G cg05573699 chr3:52720067 GNL3;PBRM1 -0.47 -6.68 -0.35 1.03e-10 Bipolar disorder; CRC cis rs6088590 0.561 rs6059934 chr20:33178324 G/T cg08999081 chr20:33150536 PIGU 0.64 12.0 0.55 9.43e-28 Coronary artery disease; CRC cis rs174601 0.861 rs174584 chr11:61610750 G/A cg00603274 chr11:61596626 FADS2 -0.45 -6.63 -0.34 1.4e-10 Blood metabolite levels;Red blood cell fatty acid levels;Liver enzyme levels (alkaline phosphatase);Gondoic acid (20:1n-9) levels;Trans fatty acid levels; CRC cis rs10911390 0.744 rs115167874 chr1:183652721 T/C cg11505048 chr1:183622726 RGL1;APOBEC4 0.71 6.24 0.33 1.33e-9 Systemic lupus erythematosus; CRC cis rs4819052 0.851 rs2255766 chr21:46683777 C/T cg19498844 chr21:46707878 POFUT2;LOC642852 0.8 11.69 0.54 1.24e-26 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs7845219 0.597 rs7002058 chr8:95873993 G/C cg13393036 chr8:95962371 TP53INP1 -0.43 -7.09 -0.36 8.09e-12 Type 2 diabetes; CRC cis rs11212617 1.000 rs227087 chr11:108244114 T/C cg12106634 chr11:108092400 ATM;NPAT 0.44 6.64 0.34 1.27e-10 Response to metformin in type 2 diabetes (glycemic); CRC cis rs10876993 0.784 rs1871417 chr12:58018979 C/T cg15848620 chr12:58087721 OS9 0.59 7.95 0.4 3.07e-14 Celiac disease or Rheumatoid arthritis; CRC trans rs1005277 0.540 rs116205409 chr10:38478970 G/A cg27523141 chr10:43048294 ZNF37B 0.47 6.74 0.35 7.02e-11 Extrinsic epigenetic age acceleration; CRC cis rs740160 0.558 rs12538893 chr7:98908497 G/A cg24650262 chr7:98904301 NA 0.56 6.06 0.32 3.73e-9 Dehydroepiandrosterone sulphate levels; CRC trans rs57590327 0.503 rs9880844 chr3:81507217 C/T cg23387109 chr10:94051229 MARCH5;CPEB3 -0.44 -6.0 -0.31 5.25e-9 Extraversion; CRC trans rs13046373 0.905 rs4816372 chr21:32077414 A/T cg12255352 chr13:24375209 MIPEP -0.37 -6.06 -0.32 3.62e-9 HDL cholesterol; CRC cis rs6662572 0.737 rs55765474 chr1:46401170 G/T cg08644498 chr1:46502608 NA 0.44 6.89 0.36 2.77e-11 Blood protein levels; CRC trans rs2303319 0.504 rs62189055 chr2:162625749 C/A cg22627826 chr19:1240265 ATP5D -0.72 -6.18 -0.32 1.86e-9 Cognitive function; CRC cis rs6570726 0.577 rs441982 chr6:145842848 A/G cg23711669 chr6:146136114 FBXO30 0.62 9.19 0.45 4.62e-18 Lobe attachment (rater-scored or self-reported); CRC cis rs34779708 0.931 rs7897457 chr10:35386040 A/G cg03585969 chr10:35415529 CREM 0.57 7.63 0.39 2.63e-13 Inflammatory bowel disease;Crohn's disease; CRC cis rs8177253 0.761 rs1830084 chr3:133508464 A/T cg01448562 chr3:133502909 NA 0.72 13.15 0.59 4.91e-32 Iron status biomarkers; CRC cis rs367943 0.966 rs348932 chr5:112812457 G/A cg12552261 chr5:112820674 MCC -0.49 -7.66 -0.39 2.06e-13 Type 2 diabetes; CRC trans rs11098499 0.863 rs1480940 chr4:120457682 T/C cg25214090 chr10:38739885 LOC399744 0.64 9.99 0.48 1.03e-20 Corneal astigmatism; CRC cis rs9457247 0.663 rs9459845 chr6:167440501 C/G cg07741184 chr6:167504864 NA 0.36 6.38 0.33 6.18e-10 Crohn's disease; CRC cis rs6558530 0.965 rs730377 chr8:1707951 G/A cg19131313 chr8:1704013 NA -0.45 -6.12 -0.32 2.65e-9 Systolic blood pressure; CRC cis rs9409565 0.559 rs62581187 chr9:97242284 T/G cg04523069 chr9:97136363 HIATL1 0.43 5.88 0.31 9.92e-9 Colorectal cancer (alcohol consumption interaction); CRC cis rs34172651 0.917 rs11640931 chr16:24797919 A/G cg06505273 chr16:24850292 NA 0.37 5.68 0.3 3.02e-8 Intelligence (multi-trait analysis); CRC cis rs1971762 0.527 rs1683151 chr12:53946219 C/G cg06632207 chr12:54070931 ATP5G2 -0.49 -8.37 -0.42 1.63e-15 Height; CRC cis rs231513 0.911 rs231521 chr17:41955158 A/G cg26893861 chr17:41843967 DUSP3 -0.7 -6.46 -0.34 3.69e-10 Cognitive function; CRC cis rs1799949 1.000 rs4793194 chr17:41218333 G/A cg25072359 chr17:41440525 NA 0.46 6.97 0.36 1.71e-11 Menopause (age at onset); CRC cis rs9914988 0.943 rs4795459 chr17:27113726 G/C cg20469991 chr17:27169893 C17orf63 -0.6 -7.27 -0.37 2.59e-12 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs6693567 0.545 rs6699093 chr1:150440451 A/G cg15654264 chr1:150340011 RPRD2 -0.4 -5.91 -0.31 8.48e-9 Migraine; CRC cis rs10737909 0.510 rs12025158 chr1:15539259 A/G cg21012057 chr1:15538911 TMEM51 0.39 5.61 0.3 4.24e-8 Migraine; CRC cis rs17401966 1.000 rs12130220 chr1:10359944 T/G cg19773385 chr1:10388646 KIF1B -0.56 -7.83 -0.4 6.65e-14 Hepatocellular carcinoma; CRC cis rs7020830 0.931 rs13297576 chr9:37142189 A/C cg14294708 chr9:37120828 ZCCHC7 1.22 28.81 0.85 5.44e-92 Schizophrenia; CRC cis rs7727544 0.716 rs4705928 chr5:131578637 A/G cg22638593 chr5:131593259 PDLIM4 -0.36 -6.61 -0.34 1.57e-10 Blood metabolite levels; CRC cis rs651907 0.535 rs11919389 chr3:101424458 T/C cg11279151 chr3:101281821 RG9MTD1 -0.54 -7.3 -0.37 2.24e-12 Colorectal cancer; CRC cis rs875971 0.638 rs3898855 chr7:66036398 G/C cg00343986 chr7:65444356 GUSB -0.5 -7.43 -0.38 9.64e-13 Aortic root size; CRC cis rs60733400 0.818 rs10909839 chr1:2708430 G/A cg18854424 chr1:2615690 NA 0.42 7.94 0.4 3.13e-14 Multiple sclerosis; CRC cis rs9894429 0.789 rs7213849 chr17:79567610 C/T cg21028142 chr17:79581711 NPLOC4 -0.33 -6.98 -0.36 1.64e-11 Eye color traits; CRC cis rs644799 0.710 rs666398 chr11:95551136 C/T cg03916912 chr11:95522834 CEP57;FAM76B 0.85 15.75 0.66 4.84e-42 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs10504073 0.647 rs10435612 chr8:49993696 A/T cg00325661 chr8:49890786 NA 0.52 9.14 0.45 6.5e-18 Blood metabolite ratios; CRC cis rs4665809 0.680 rs3955310 chr2:26290828 T/G cg22920501 chr2:26401640 FAM59B -0.52 -7.15 -0.37 5.6e-12 Gut microbiome composition (summer); CRC cis rs644799 0.544 rs1622515 chr11:95523433 A/G cg03916912 chr11:95522834 CEP57;FAM76B 0.71 11.62 0.54 2.1e-26 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs25422 0.938 rs62422193 chr6:118912285 G/A cg22561889 chr6:118971681 C6orf204 0.47 5.9 0.31 8.96e-9 Renal cell carcinoma; CRC cis rs9916302 0.752 rs9901219 chr17:37558369 T/G cg00129232 chr17:37814104 STARD3 0.54 7.34 0.38 1.68e-12 Glomerular filtration rate (creatinine); CRC trans rs1200821 0.535 rs1938417 chr10:37687520 A/C cg25427524 chr10:38739819 LOC399744 0.54 8.6 0.43 3.41e-16 Hemostatic factors and hematological phenotypes; CRC cis rs12760731 0.565 rs35926996 chr1:178075351 A/G cg00404053 chr1:178313656 RASAL2 1.06 11.28 0.53 3.67e-25 Obesity-related traits; CRC cis rs9916302 0.808 rs12943928 chr17:37611330 G/A cg15445000 chr17:37608096 MED1 0.43 9.47 0.46 5.76e-19 Glomerular filtration rate (creatinine); CRC cis rs71386933 0.543 rs36114735 chr16:72017683 C/T cg08717414 chr16:71523259 ZNF19 -0.87 -7.18 -0.37 4.62e-12 Post bronchodilator FEV1; CRC cis rs8044995 0.517 rs2863973 chr16:68409435 A/C cg05110241 chr16:68378359 PRMT7 -0.6 -7.21 -0.37 3.85e-12 Schizophrenia; CRC cis rs6951245 1.000 rs11763835 chr7:1094513 A/G cg20603222 chr7:1096387 C7orf50;GPR146 -0.72 -8.68 -0.43 1.87e-16 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC trans rs6951245 1.000 rs79765398 chr7:1073764 A/G cg13565492 chr6:43139072 SRF -0.71 -7.2 -0.37 4.12e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs812925 0.512 rs1729674 chr2:61389737 T/G cg10580144 chr2:61372316 C2orf74 0.36 8.07 0.41 1.34e-14 Immature fraction of reticulocytes; CRC cis rs7659604 0.605 rs1507994 chr4:122749541 C/T cg19748678 chr4:122722346 EXOSC9 0.58 9.5 0.46 4.41e-19 Type 2 diabetes; CRC cis rs6952808 0.756 rs4719311 chr7:1881813 C/T cg20295408 chr7:1910781 MAD1L1 -0.44 -6.45 -0.34 3.92e-10 Bipolar disorder and schizophrenia; CRC cis rs539096 0.566 rs3011220 chr1:44308867 A/G cg13606994 chr1:44402422 ARTN -0.34 -5.86 -0.31 1.12e-8 Intelligence (multi-trait analysis); CRC cis rs3806843 0.551 rs184996 chr5:140323773 T/A cg19875535 chr5:140030758 IK 0.39 6.02 0.31 4.67e-9 Depressive symptoms (multi-trait analysis); CRC cis rs10782582 0.593 rs11589276 chr1:76105545 G/A cg03433033 chr1:76189801 ACADM -0.44 -6.38 -0.33 6.15e-10 Daytime sleep phenotypes; CRC cis rs2732480 0.577 rs2732479 chr12:48736260 A/C cg04545296 chr12:48745243 ZNF641 0.36 6.22 0.32 1.49e-9 Hemoglobin concentration;Red blood cell count;Hematocrit; CRC cis rs2239547 0.657 rs7638524 chr3:52874861 G/A cg11645453 chr3:52864694 ITIH4 0.6 10.66 0.51 5.32e-23 Schizophrenia; CRC cis rs6502050 0.835 rs34867501 chr17:80121358 T/C cg25804541 chr17:80189381 SLC16A3 -0.31 -5.95 -0.31 6.84e-9 Life satisfaction; CRC trans rs12310956 0.532 rs6488187 chr12:33975029 C/T cg26384229 chr12:38710491 ALG10B 0.45 6.05 0.32 3.85e-9 Morning vs. evening chronotype; CRC cis rs12980942 0.872 rs10421990 chr19:41797099 C/T cg25627403 chr19:41769009 HNRNPUL1 0.44 5.66 0.3 3.24e-8 Coronary artery disease; CRC cis rs17401966 0.838 rs34636442 chr1:10427459 T/G cg19773385 chr1:10388646 KIF1B -0.66 -10.66 -0.51 5.35e-23 Hepatocellular carcinoma; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg05663122 chr19:59055778 TRIM28 0.37 6.0 0.31 5.17e-9 Liver disease severity in Alagille syndrome; CRC cis rs6951245 0.935 rs113365567 chr7:1108785 T/C cg04025307 chr7:1156635 C7orf50 0.66 7.07 0.36 9.23e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs2303745 0.589 rs11086065 chr19:17395003 A/G cg02221750 chr19:17393354 ANKLE1 -0.43 -6.61 -0.34 1.54e-10 Systemic lupus erythematosus; CRC cis rs7927592 0.763 rs4340059 chr11:68362433 A/G cg16797656 chr11:68205561 LRP5 0.49 9.0 0.44 1.87e-17 Total body bone mineral density; CRC cis rs10504229 0.679 rs11781858 chr8:58038406 C/T cg21724239 chr8:58056113 NA 0.73 8.87 0.44 4.88e-17 Developmental language disorder (linguistic errors); CRC cis rs4737010 0.570 rs10112594 chr8:41645565 C/T cg17182837 chr8:41585554 ANK1 -0.55 -7.75 -0.39 1.17e-13 Lymphocyte counts;High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Reticulocyte count;Reticulocyte fraction of red cells;Mean corpuscular volume;Immature fraction of reticulocytes;Mean corpuscular hemoglobin concentration; CRC cis rs910316 1.000 rs2300601 chr14:75639571 A/G cg11812906 chr14:75593930 NEK9 0.65 10.05 0.48 6.52e-21 Height; CRC cis rs561341 0.700 rs79272796 chr17:30226974 T/C cg00745463 chr17:30367425 LRRC37B -0.45 -5.99 -0.31 5.61e-9 Hip circumference adjusted for BMI; CRC cis rs875971 0.830 rs809025 chr7:65849819 C/G cg18876405 chr7:65276391 NA 0.51 8.56 0.43 4.3e-16 Aortic root size; CRC cis rs2180341 0.920 rs6906717 chr6:127596782 C/A cg24812749 chr6:127587940 RNF146 0.94 13.67 0.6 5.36e-34 Breast cancer; CRC cis rs1322512 1.000 rs2800625 chr6:153006016 A/G cg03415253 chr6:152958462 SYNE1 0.4 6.04 0.32 4.18e-9 Tonometry; CRC cis rs9818758 0.607 rs9862483 chr3:49195441 G/A cg07636037 chr3:49044803 WDR6 -0.7 -5.91 -0.31 8.32e-9 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; CRC cis rs875971 0.964 rs778708 chr7:65856319 T/C cg18912574 chr7:65842487 NCRNA00174 0.36 6.18 0.32 1.88e-9 Aortic root size; CRC trans rs6981523 0.553 rs11783045 chr8:11056175 A/G cg16141378 chr3:129829833 LOC729375 0.42 5.98 0.31 5.78e-9 Neuroticism; CRC cis rs597539 0.690 rs578791 chr11:68625809 C/T cg04772025 chr11:68637568 NA 0.53 8.26 0.41 3.71e-15 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC trans rs61931739 0.533 rs4270002 chr12:34313126 G/T cg26384229 chr12:38710491 ALG10B 0.45 6.31 0.33 9.05e-10 Morning vs. evening chronotype; CRC cis rs6570726 0.935 rs385185 chr6:145814992 A/G cg05347473 chr6:146136440 FBXO30 0.37 5.93 0.31 7.63e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs754466 0.580 rs10824576 chr10:79566040 G/C cg17075019 chr10:79541650 NA -0.95 -17.95 -0.7 1e-50 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs4589502 0.800 rs12595796 chr15:67202599 A/G cg12317470 chr15:67143691 NA -0.51 -6.03 -0.32 4.31e-9 Lung cancer (smoking interaction); CRC cis rs8060686 0.621 rs35432211 chr16:68095449 T/C cg26727032 chr16:67993705 SLC12A4 -0.57 -6.54 -0.34 2.37e-10 HDL cholesterol;Metabolic syndrome; CRC cis rs9911578 0.967 rs12938821 chr17:56959422 T/C cg05425664 chr17:57184151 TRIM37 -0.49 -7.77 -0.39 1.03e-13 Intelligence (multi-trait analysis); CRC trans rs116095464 0.558 rs57335027 chr5:262907 A/G cg00938859 chr5:1591904 SDHAP3 0.73 7.89 0.4 4.53e-14 Breast cancer; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg06210969 chr3:120067732 LRRC58 0.42 6.0 0.31 5.22e-9 Intelligence (multi-trait analysis); CRC trans rs2303319 0.504 rs56965753 chr2:162597251 A/G cg22677401 chr17:46026860 NA -0.67 -6.07 -0.32 3.57e-9 Cognitive function; CRC cis rs8180040 0.691 rs12489211 chr3:47221451 T/A cg10298567 chr3:47292165 KIF9 -0.36 -5.89 -0.31 9.67e-9 Colorectal cancer; CRC cis rs2976388 1.000 rs2920298 chr8:143763043 A/G cg04969067 chr8:143858791 LYNX1 -0.34 -5.82 -0.31 1.38e-8 Urinary tract infection frequency; CRC trans rs16846053 0.786 rs72873645 chr2:162495047 G/A cg13490827 chr1:46269305 MAST2 -0.7 -6.28 -0.33 1.09e-9 Blood osmolality (transformed sodium); CRC cis rs897984 0.770 rs3813020 chr16:30934075 G/A cg00531865 chr16:30841666 NA 0.49 7.0 0.36 1.48e-11 Dementia with Lewy bodies; CRC cis rs3733585 0.673 rs4312757 chr4:9956145 T/A cg00071950 chr4:10020882 SLC2A9 -0.55 -9.75 -0.47 6.56e-20 Cleft plate (environmental tobacco smoke interaction); CRC cis rs7680126 0.633 rs11727390 chr4:10296760 C/T cg11266682 chr4:10021025 SLC2A9 -0.44 -6.71 -0.35 8.56e-11 Urate levels in lean individuals;Urate levels in overweight individuals;Urate levels in obese individuals; CRC trans rs1864729 1.000 rs2583504 chr8:98283404 G/C cg08679828 chr8:102218111 ZNF706 -0.59 -7.13 -0.37 6.34e-12 Estradiol plasma levels (breast cancer); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg14850412 chr1:200860682 C1orf106 0.42 6.24 0.33 1.38e-9 Response to antipsychotic treatment; CRC cis rs807029 0.533 rs3740485 chr10:102750621 C/T cg04662943 chr10:102668895 NA 0.59 7.25 0.37 3.07e-12 Ejection fraction in Tripanosoma cruzi seropositivity; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg06655377 chr16:56553780 BBS2 0.42 5.97 0.31 6.1e-9 Intelligence (multi-trait analysis); CRC cis rs6502050 0.835 rs6502079 chr17:80124454 T/A cg19223190 chr17:80058835 NA 0.39 6.23 0.32 1.43e-9 Life satisfaction; CRC cis rs910316 1.000 rs1043674 chr14:75549370 T/C cg03030879 chr14:75389066 RPS6KL1 -0.46 -7.33 -0.37 1.8e-12 Height; CRC cis rs7568458 0.811 rs3755015 chr2:85764041 G/A cg02493740 chr2:85810744 VAMP5 -0.4 -6.28 -0.33 1.09e-9 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); CRC cis rs7385804 0.796 rs221801 chr7:100290031 C/A cg16850897 chr7:100343110 ZAN 0.46 6.94 0.36 2.11e-11 Iron status biomarkers;Mean corpuscular hemoglobin;Hematocrit;Iron status biomarkers (transferrin saturation);Red blood cell count;Iron status biomarkers (iron levels);Mean corpuscular volume;Hematological parameters; CRC cis rs870825 0.655 rs2310104 chr4:185619967 A/G cg04058563 chr4:185651563 MLF1IP 0.72 9.38 0.46 1.12e-18 Blood protein levels; CRC trans rs13046373 0.905 rs4816372 chr21:32077414 A/T cg15271348 chr13:114292740 TFDP1 -0.38 -6.04 -0.32 4.15e-9 HDL cholesterol; CRC trans rs2228479 0.850 rs11649510 chr16:89851004 A/G cg24644049 chr4:85504048 CDS1 0.92 7.64 0.39 2.42e-13 Skin colour saturation; CRC cis rs7119 0.604 rs2667781 chr15:77858619 A/C cg10437265 chr15:77819839 NA -0.52 -8.53 -0.43 5.37e-16 Type 2 diabetes; CRC cis rs2032447 0.714 rs199725 chr6:25953684 A/G cg18357526 chr6:26021779 HIST1H4A 0.67 9.92 0.48 1.8e-20 Intelligence (multi-trait analysis); CRC cis rs1862618 0.853 rs832569 chr5:56154584 T/A cg18230493 chr5:56204884 C5orf35 -0.73 -9.18 -0.45 4.8e-18 Initial pursuit acceleration; CRC cis rs7590720 1.000 rs934156 chr2:216901482 C/T cg12620499 chr2:216877984 MREG -0.86 -13.96 -0.61 4.27e-35 Alcohol dependence; CRC cis rs9914988 0.943 rs9891925 chr17:27104540 A/T cg20469991 chr17:27169893 C17orf63 -0.6 -7.27 -0.37 2.59e-12 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC trans rs1880529 0.830 rs6533687 chr4:114365275 C/T cg05422836 chr8:81806286 NA -0.4 -6.01 -0.31 5.02e-9 White matter integrity (bipolar disorder risk interaction); CRC cis rs9322193 0.924 rs9498382 chr6:149932118 A/G cg00933542 chr6:150070202 PCMT1 0.29 6.05 0.32 3.94e-9 Lung cancer; CRC cis rs7552404 0.727 rs7547056 chr1:76279267 C/T cg03433033 chr1:76189801 ACADM 0.69 9.12 0.45 7.51e-18 Blood metabolite levels;Acylcarnitine levels; CRC cis rs4481887 1.000 rs4244172 chr1:248466838 A/G cg00666640 chr1:248458726 OR2T12 0.53 9.32 0.46 1.72e-18 Common traits (Other); CRC cis rs863345 0.604 rs879635 chr1:158462908 C/T cg12129480 chr1:158549410 OR10X1 -0.3 -6.31 -0.33 8.84e-10 Pneumococcal bacteremia; CRC cis rs11098499 0.730 rs12505735 chr4:120532956 G/T cg24375607 chr4:120327624 NA 0.52 7.79 0.39 8.6e-14 Corneal astigmatism; CRC cis rs3091242 0.933 rs11249250 chr1:25767609 G/A cg27572855 chr1:25598939 RHD 0.35 6.19 0.32 1.8e-9 Erythrocyte sedimentation rate; CRC cis rs9894429 0.700 rs113915083 chr17:79552696 G/C cg21028142 chr17:79581711 NPLOC4 -0.34 -7.02 -0.36 1.26e-11 Eye color traits; CRC trans rs2797369 0.824 rs1149271 chr6:101608851 A/G cg26346621 chr12:6873348 NA -0.39 -6.14 -0.32 2.44e-9 Renal function-related traits (eGRFcrea); CRC cis rs3862030 0.500 rs11191327 chr10:104303883 T/C cg11453585 chr10:104263688 ACTR1A;SUFU 0.91 17.33 0.69 2.88e-48 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for body mass index; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg20400718 chr8:42940792 FNTA -0.37 -6.22 -0.32 1.52e-9 Liver disease severity in Alagille syndrome; CRC cis rs34375054 0.624 rs12580033 chr12:125676083 A/T cg06287003 chr12:125626642 AACS -0.58 -7.49 -0.38 6.42e-13 Post bronchodilator FEV1/FVC ratio; CRC cis rs11212617 0.902 rs61913892 chr11:108340216 T/C cg01991180 chr11:108092276 ATM;NPAT 0.42 6.15 0.32 2.21e-9 Response to metformin in type 2 diabetes (glycemic); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg21531444 chr3:178961439 KCNMB3 -0.39 -6.06 -0.32 3.73e-9 Liver disease severity in Alagille syndrome; CRC cis rs534126 0.744 rs10248147 chr7:142941023 C/G cg04039957 chr7:143013207 CLCN1 -0.34 -5.64 -0.3 3.71e-8 Cancer; CRC cis rs9814567 0.752 rs1534030 chr3:134330083 C/T cg06109529 chr3:134205091 CEP63;ANAPC13 -0.67 -9.58 -0.47 2.53e-19 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs6499255 0.951 rs689455 chr16:69761661 T/G cg04110750 chr16:69646130 NFAT5 -0.54 -7.35 -0.38 1.63e-12 IgE levels; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg27481254 chr8:94753071 RBM12B 0.48 6.38 0.33 6.18e-10 Thyroid stimulating hormone; CRC cis rs736408 0.609 rs13095332 chr3:52787242 C/T cg07507251 chr3:52567010 NT5DC2 0.45 6.39 0.33 5.82e-10 Bipolar disorder; CRC cis rs344364 0.602 rs2437744 chr16:1908451 C/T cg14074117 chr16:1909714 C16orf73 -0.34 -5.81 -0.31 1.44e-8 Glomerular filtration rate in chronic kidney disease; CRC cis rs4713675 0.565 rs2274458 chr6:33679596 A/C cg14003231 chr6:33640908 ITPR3 0.49 7.82 0.4 7.19e-14 Plateletcrit; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg23037918 chr19:7600138 PNPLA6 0.43 6.11 0.32 2.78e-9 Response to antipsychotic treatment; CRC cis rs449789 0.857 rs10806706 chr6:159721945 G/T cg14500486 chr6:159655392 FNDC1 0.48 7.38 0.38 1.3e-12 Pulse pressure; CRC trans rs875971 0.660 rs2191268 chr7:66110224 C/T cg24998145 chr1:150550761 MCL1 -0.43 -6.82 -0.35 4.38e-11 Aortic root size; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg12648201 chr2:27665141 KRTCAP3 0.32 6.83 0.35 4e-11 Liver disease severity in Alagille syndrome; CRC cis rs6424115 0.708 rs12748109 chr1:24181177 C/T cg08896387 chr1:24191740 FUCA1 0.52 7.01 0.36 1.32e-11 Immature fraction of reticulocytes; CRC trans rs2540226 0.527 rs11124695 chr2:40026583 G/A cg05727001 chr11:66718583 PC 0.41 6.01 0.31 4.91e-9 Personality dimensions; CRC cis rs12802200 0.561 rs7940600 chr11:572105 A/G cg09218773 chr11:619014 MUPCDH -0.36 -5.66 -0.3 3.29e-8 Systemic lupus erythematosus; CRC cis rs11864453 1.000 rs11864453 chr16:72050480 C/T cg01557791 chr16:72042693 DHODH -0.51 -7.19 -0.37 4.43e-12 Fibrinogen levels; CRC cis rs9291683 0.935 rs1860910 chr4:10275470 T/G cg11266682 chr4:10021025 SLC2A9 0.44 9.19 0.45 4.44e-18 Bone mineral density; CRC cis rs10876993 0.928 rs1689594 chr12:58057156 T/C cg15848620 chr12:58087721 OS9 -0.65 -9.38 -0.46 1.15e-18 Celiac disease or Rheumatoid arthritis; CRC cis rs13082711 0.911 rs923941 chr3:27458914 A/G cg02860705 chr3:27208620 NA 0.62 8.79 0.44 8.3e-17 Systolic blood pressure;Diastolic blood pressure;Blood pressure; CRC cis rs9325144 0.510 rs6582599 chr12:38715965 T/G cg26384229 chr12:38710491 ALG10B 0.58 8.57 0.43 4.13e-16 Morning vs. evening chronotype; CRC cis rs6586163 1.000 rs6586165 chr10:90755056 T/A cg13456138 chr10:90753195 FAS -0.43 -6.62 -0.34 1.5e-10 Chronic lymphocytic leukemia; CRC cis rs763121 0.819 rs5757160 chr22:38989646 T/C cg06022373 chr22:39101656 GTPBP1 0.79 13.12 0.59 6.43e-32 Menopause (age at onset); CRC cis rs67311347 0.955 rs9821036 chr3:40379007 A/G cg24209194 chr3:40518798 ZNF619 0.41 6.02 0.31 4.67e-9 Renal cell carcinoma; CRC cis rs2991971 0.967 rs512026 chr1:46009946 G/T cg24296786 chr1:45957014 TESK2 0.57 8.52 0.43 5.82e-16 High light scatter reticulocyte count; CRC cis rs40363 0.951 rs250632 chr16:3523047 C/T cg21433313 chr16:3507492 NAT15 0.76 8.59 0.43 3.53e-16 Tuberculosis; CRC cis rs870825 0.655 rs7683556 chr4:185632019 T/A cg04058563 chr4:185651563 MLF1IP 0.72 9.26 0.45 2.73e-18 Blood protein levels; CRC cis rs13118159 0.742 rs34947293 chr4:1335034 T/C cg21620606 chr4:1342894 KIAA1530 0.52 9.57 0.47 2.74e-19 Longevity; CRC cis rs9467773 1.000 rs6922824 chr6:26553815 C/G cg09904177 chr6:26538194 HMGN4 -0.84 -14.71 -0.63 5.44e-38 Intelligence (multi-trait analysis); CRC cis rs11628318 0.614 rs8010455 chr14:103164681 A/G cg12046867 chr14:103022105 NA 0.76 8.97 0.44 2.22e-17 Platelet count; CRC cis rs2120019 1.000 rs8036197 chr15:75370232 T/C cg09165964 chr15:75287851 SCAMP5 -0.8 -12.62 -0.57 4.92e-30 Blood trace element (Zn levels); CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg10601761 chr19:4930780 UHRF1 -0.42 -5.98 -0.31 5.86e-9 Anxiety disorder; CRC cis rs11628318 0.614 rs7154538 chr14:103068112 A/G cg23071808 chr14:103021642 NA -0.6 -6.92 -0.36 2.35e-11 Platelet count; CRC cis rs10504229 0.683 rs6980540 chr8:58127022 A/G cg04204079 chr8:58130323 NA -0.45 -5.84 -0.31 1.27e-8 Developmental language disorder (linguistic errors); CRC cis rs12580194 0.593 rs7314118 chr12:55737403 A/C cg23425280 chr12:56401806 NA 0.47 5.97 0.31 6.21e-9 Cancer; CRC cis rs2411233 1.000 rs2117207 chr15:39289254 C/T cg23129342 chr15:39283510 NA 0.33 6.19 0.32 1.78e-9 Platelet count; CRC cis rs7666738 0.830 rs7678557 chr4:99057329 A/G cg05340658 chr4:99064831 C4orf37 0.6 9.3 0.46 2.03e-18 Colonoscopy-negative controls vs population controls; CRC cis rs10504229 0.679 rs16920056 chr8:58106218 C/A cg04204079 chr8:58130323 NA -0.46 -5.79 -0.3 1.67e-8 Developmental language disorder (linguistic errors); CRC cis rs11148252 0.840 rs3886077 chr13:52949053 C/A cg02158880 chr13:53174818 NA 0.44 6.65 0.34 1.19e-10 Lewy body disease; CRC cis rs2735413 0.837 rs12920830 chr16:78083149 A/C cg04733911 chr16:78082701 NA -0.45 -7.41 -0.38 1.11e-12 Systolic blood pressure (alcohol consumption interaction); CRC cis rs2739330 0.828 rs2154593 chr22:24252085 A/G cg23131131 chr22:24373011 LOC391322 -0.66 -10.16 -0.49 2.91e-21 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs10540 0.915 rs35389167 chr11:460765 A/G cg08200582 chr11:442649 ANO9 -0.69 -7.21 -0.37 3.75e-12 Body mass index; CRC cis rs6502050 0.865 rs56193110 chr17:80151501 A/G cg09264619 chr17:80180166 NA -0.35 -5.81 -0.31 1.48e-8 Life satisfaction; CRC cis rs2839186 0.709 rs2156117 chr21:47669300 C/A cg05896524 chr21:47604654 C21orf56 0.47 7.07 0.36 9.21e-12 Testicular germ cell tumor; CRC cis rs514406 0.571 rs11206004 chr1:53210958 G/A cg08859206 chr1:53392774 SCP2 0.4 6.33 0.33 8.1e-10 Monocyte count; CRC cis rs9648716 1.000 rs7801086 chr7:140454973 G/T cg10747023 chr7:140774559 NA 0.45 5.8 0.3 1.52e-8 Type 2 diabetes; CRC cis rs8064299 0.655 rs2305214 chr17:72768970 G/A cg25054828 chr17:72772726 NAT9;TMEM104 0.66 10.1 0.49 4.4e-21 Monocyte count; CRC cis rs7259376 0.837 rs1368476 chr19:22586192 A/G cg02657401 chr19:22469223 NA 0.32 6.81 0.35 4.66e-11 Menopause (age at onset); CRC cis rs9814567 1.000 rs1880376 chr3:134270347 A/G cg06109529 chr3:134205091 CEP63;ANAPC13 0.82 12.06 0.55 5.69e-28 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs12980942 0.872 rs12976536 chr19:41799886 T/A cg25627403 chr19:41769009 HNRNPUL1 0.52 6.02 0.31 4.73e-9 Coronary artery disease; CRC cis rs13191362 0.938 rs13213746 chr6:163167777 T/A cg23758597 chr6:163146217 PARK2 -0.6 -6.68 -0.35 1.04e-10 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs1035144 0.505 rs10145099 chr14:81456694 C/T cg06600135 chr14:81408086 NA -0.54 -8.19 -0.41 5.69e-15 Male sexual orientation; CRC trans rs17780086 0.527 rs72827712 chr17:30538600 A/G cg00801512 chr17:28996047 NA -0.6 -6.1 -0.32 2.91e-9 Height; CRC cis rs2073499 1.000 rs2301639 chr3:50380661 G/A cg09545109 chr3:50388910 TUSC4;CYB561D2 0.67 5.85 0.31 1.16e-8 Schizophrenia; CRC cis rs921968 0.643 rs4674305 chr2:219293326 C/T cg02176678 chr2:219576539 TTLL4 0.48 7.87 0.4 5.21e-14 Mean corpuscular hemoglobin concentration; CRC cis rs801193 0.591 rs2707839 chr7:66193084 A/G cg18912574 chr7:65842487 NCRNA00174 0.36 5.92 0.31 8.07e-9 Aortic root size; CRC cis rs7586879 0.789 rs11688754 chr2:25133885 C/T cg22495460 chr2:25135724 ADCY3 -0.9 -14.95 -0.64 6.53e-39 Body mass index; CRC cis rs9488822 0.597 rs12214881 chr6:116342187 G/T cg18764771 chr6:116381957 FRK 0.25 7.04 0.36 1.1e-11 Cholesterol, total;LDL cholesterol; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg05263682 chr6:89673273 RNGTT 0.43 6.08 0.32 3.38e-9 Response to antipsychotic treatment; CRC cis rs6076065 0.748 rs2253834 chr20:23387816 C/T cg11657817 chr20:23433608 CST11 -0.48 -8.34 -0.42 2.09e-15 Facial morphology (factor 15, philtrum width); CRC cis rs7605827 0.930 rs13006997 chr2:15700872 T/C cg19274914 chr2:15703543 NA 0.37 5.62 0.3 4.13e-8 Educational attainment (years of education); CRC cis rs10504229 0.815 rs72650879 chr8:58164648 A/G cg11062466 chr8:58055876 NA 0.45 5.81 0.3 1.49e-8 Developmental language disorder (linguistic errors); CRC trans rs629535 0.814 rs614050 chr8:70065642 G/A cg21567404 chr3:27674614 NA 0.92 15.29 0.64 2.9e-40 Dupuytren's disease; CRC cis rs2075671 0.903 rs11520986 chr7:100276994 A/G cg00334542 chr7:100209784 MOSPD3 -0.51 -6.59 -0.34 1.76e-10 Other erythrocyte phenotypes; CRC cis rs3749237 0.595 rs3870338 chr3:49557051 A/G cg02487422 chr3:49467188 NICN1 0.43 7.09 0.36 8.17e-12 Resting heart rate; CRC cis rs7552404 0.924 rs12136754 chr1:76230232 C/A cg03433033 chr1:76189801 ACADM 0.91 13.82 0.61 1.42e-34 Blood metabolite levels;Acylcarnitine levels; CRC cis rs1843834 0.539 rs12694643 chr2:225446603 A/G cg22455342 chr2:225449267 CUL3 0.68 9.27 0.46 2.46e-18 IgE levels in asthmatics (D.p. specific); CRC cis rs9914988 0.887 rs12947735 chr17:27156866 A/T cg12682573 chr17:27188876 MIR451;MIR144 0.57 7.96 0.4 2.85e-14 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs13118159 0.550 rs28522910 chr4:1374774 C/T cg05025164 chr4:1340916 KIAA1530 0.53 7.54 0.38 4.71e-13 Longevity; CRC cis rs4604732 0.588 rs4925551 chr1:247631724 T/A cg02104434 chr1:247694406 LOC148824;OR2C3 0.54 8.14 0.41 8.34e-15 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CRC cis rs9549328 0.700 rs4907570 chr13:113617651 T/C cg17524180 chr13:113633600 MCF2L 0.52 9.51 0.46 4.24e-19 Systolic blood pressure; CRC cis rs2688482 0.557 rs3103952 chr3:195522690 T/C cg18713687 chr3:195489789 MUC4 0.67 7.39 0.38 1.22e-12 Lung disease severity in cystic fibrosis; CRC cis rs4713118 0.869 rs9461400 chr6:27700559 A/G cg02683197 chr6:28174875 NA 0.63 8.62 0.43 2.81e-16 Parkinson's disease; CRC cis rs6963495 0.818 rs56177071 chr7:105165648 C/T cg13798780 chr7:105162888 PUS7 0.69 8.2 0.41 5.36e-15 Bipolar disorder (body mass index interaction); CRC cis rs7044106 0.762 rs1530370 chr9:123424552 C/T cg09586646 chr9:123605570 PSMD5;LOC253039 0.62 8.83 0.44 6.4e-17 Hip circumference adjusted for BMI; CRC cis rs763121 0.853 rs35565791 chr22:39063011 C/A cg06022373 chr22:39101656 GTPBP1 0.8 12.71 0.57 2.19e-30 Menopause (age at onset); CRC cis rs10504073 0.584 rs60449482 chr8:49974865 G/A cg00325661 chr8:49890786 NA 0.6 10.82 0.51 1.56e-23 Blood metabolite ratios; CRC cis rs2832191 0.716 rs7509628 chr21:30454252 C/T cg24692254 chr21:30365293 RNF160 0.85 16.14 0.66 1.48e-43 Dental caries; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg03324947 chr7:42971765 PSMA2;MRPL32 0.39 6.56 0.34 2.04e-10 Liver disease severity in Alagille syndrome; CRC cis rs863345 0.604 rs1342946 chr1:158453187 C/T cg12129480 chr1:158549410 OR10X1 -0.29 -5.99 -0.31 5.56e-9 Pneumococcal bacteremia; CRC cis rs8077889 1.000 rs17674998 chr17:41879544 A/G cg26893861 chr17:41843967 DUSP3 0.88 11.41 0.53 1.21e-25 Triglycerides; CRC cis rs4713118 0.662 rs149969 chr6:27977737 A/G cg06470822 chr6:28175283 NA 0.9 13.82 0.61 1.49e-34 Parkinson's disease; CRC cis rs1552244 1.000 rs17032268 chr3:10067972 C/T cg13047869 chr3:10149882 C3orf24 0.51 7.07 0.36 9.31e-12 Alzheimer's disease; CRC cis rs9326248 0.953 rs488962 chr11:117072525 C/T cg10130564 chr11:117069849 TAGLN -0.37 -6.73 -0.35 7.77e-11 Blood protein levels; CRC cis rs3820928 0.839 rs12470666 chr2:227876525 G/A cg11843606 chr2:227700838 RHBDD1 -0.41 -5.88 -0.31 1.02e-8 Pulmonary function; CRC cis rs428668 0.523 rs10060607 chr5:150679304 A/C cg14086364 chr5:150678334 SLC36A3 0.4 6.89 0.36 2.8e-11 Skin aging (microtopography measurement); CRC cis rs4927850 0.881 rs7630489 chr3:195753401 T/C cg12923728 chr3:195709715 SDHAP1 -0.7 -10.9 -0.52 7.9e-24 Pancreatic cancer; CRC cis rs875971 0.929 rs6970860 chr7:65976634 A/G cg12463550 chr7:65579703 CRCP 0.47 6.79 0.35 5.17e-11 Aortic root size; CRC cis rs12024301 0.557 rs10797895 chr1:183589625 C/T cg11505048 chr1:183622726 RGL1;APOBEC4 0.76 6.93 0.36 2.16e-11 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs7927592 0.731 rs643609 chr11:68241833 A/G cg01657329 chr11:68192670 LRP5 -0.54 -8.93 -0.44 3.04e-17 Total body bone mineral density; CRC cis rs79349575 0.783 rs17708633 chr17:47011620 C/G cg22482690 chr17:47019901 SNF8 0.48 8.01 0.4 2.01e-14 Type 2 diabetes; CRC cis rs910316 0.967 rs7146523 chr14:75659880 T/C cg11812906 chr14:75593930 NEK9 -0.49 -7.32 -0.37 1.9e-12 Height; CRC cis rs17711722 0.701 rs781143 chr7:65439879 G/C cg11764359 chr7:65958608 NA 0.52 7.87 0.4 5.22e-14 Calcium levels; CRC cis rs6502050 0.799 rs4789680 chr17:80100547 C/A cg22110888 chr17:80059540 CCDC57 0.4 6.44 0.33 4.17e-10 Life satisfaction; CRC cis rs2976388 0.647 rs2585136 chr8:143812141 A/G cg20041105 chr8:143859282 LYNX1 0.46 8.2 0.41 5.51e-15 Urinary tract infection frequency; CRC trans rs1005277 0.602 rs2504142 chr10:38383793 C/T cg17830980 chr10:43048298 ZNF37B -0.6 -9.93 -0.48 1.67e-20 Extrinsic epigenetic age acceleration; CRC cis rs939584 0.932 rs1320336 chr2:650012 G/A cg03610516 chr2:642275 NA -0.42 -5.89 -0.31 9.71e-9 Body mass index; CRC cis rs4970988 0.527 rs12067556 chr1:150614535 G/A cg15448220 chr1:150897856 SETDB1 0.49 6.82 0.35 4.3e-11 Urate levels; CRC cis rs9303401 0.614 rs34900851 chr17:56566399 G/A cg10487724 chr17:56770010 TEX14;RAD51C 0.79 9.63 0.47 1.63e-19 Cognitive test performance; CRC cis rs28386778 0.897 rs9906247 chr17:61857314 T/C cg06601766 chr17:61851465 DDX42;CCDC47 0.46 6.23 0.32 1.46e-9 Prudent dietary pattern; CRC cis rs1524976 1.000 rs2030732 chr3:65465766 T/C cg16238336 chr3:65465873 MAGI1 0.5 7.22 0.37 3.64e-12 PR interval; CRC cis rs6951245 1.000 rs74887741 chr7:1110658 G/T cg22907277 chr7:1156413 C7orf50 0.74 7.77 0.39 9.78e-14 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs17376456 0.877 rs10476596 chr5:93367074 C/T cg21475434 chr5:93447410 FAM172A -0.76 -7.7 -0.39 1.56e-13 Diabetic retinopathy; CRC cis rs589448 0.967 rs2617834 chr12:69753365 T/C cg22834771 chr12:69754056 YEATS4 -0.56 -8.73 -0.43 1.33e-16 Cerebrospinal fluid biomarker levels; CRC cis rs9868809 0.881 rs7620853 chr3:48666503 G/A cg00383909 chr3:49044727 WDR6 0.78 7.86 0.4 5.41e-14 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; CRC cis rs9902453 0.899 rs1979572 chr17:28511978 G/A cg26525008 chr17:28256777 EFCAB5;SSH2 0.61 9.47 0.46 5.58e-19 Coffee consumption (cups per day); CRC cis rs9926296 0.609 rs4785714 chr16:89798404 G/T cg04287289 chr16:89883240 FANCA -0.55 -8.55 -0.43 4.64e-16 Vitiligo; CRC cis rs11645898 0.687 rs72787058 chr16:72105084 C/T cg14768367 chr16:72042858 DHODH -0.54 -6.01 -0.31 4.83e-9 Blood protein levels; CRC cis rs9467773 1.000 rs6926629 chr6:26499903 T/C cg09904177 chr6:26538194 HMGN4 0.85 14.65 0.63 9.4e-38 Intelligence (multi-trait analysis); CRC cis rs7927771 0.507 rs1483988 chr11:47899030 C/T cg20307385 chr11:47447363 PSMC3 0.48 6.94 0.36 2.12e-11 Subjective well-being; CRC cis rs6062302 0.522 rs6089929 chr20:62219679 C/T cg16989086 chr20:62203971 PRIC285 0.48 6.21 0.32 1.57e-9 Glioblastoma; CRC cis rs4974559 0.790 rs2293631 chr4:1315917 C/A cg02980000 chr4:1222292 CTBP1 0.48 6.05 0.32 3.93e-9 Systolic blood pressure; CRC cis rs12541635 0.966 rs56352125 chr8:107041831 G/T cg10147462 chr8:107024639 NA 0.47 7.7 0.39 1.59e-13 Age of smoking initiation; CRC cis rs425277 0.538 rs169037 chr1:2095582 G/T cg04315214 chr1:2043799 PRKCZ -0.38 -6.6 -0.34 1.69e-10 Height; CRC cis rs7827545 1.000 rs6578232 chr8:135565690 G/A cg07299736 chr8:135490787 ZFAT -0.37 -6.2 -0.32 1.73e-9 Hypertension (SNP x SNP interaction); CRC cis rs11255291 1.000 rs10905219 chr10:7738411 C/T cg00997801 chr10:7671259 ITIH5 0.46 6.67 0.35 1.06e-10 Ovarian reserve; CRC cis rs9354308 0.901 rs12197136 chr6:66590953 T/C cg07460842 chr6:66804631 NA 0.46 5.83 0.31 1.35e-8 Metabolite levels; CRC trans rs10155879 0.505 rs12704265 chr7:86142678 A/G cg24415082 chr16:74700811 RFWD3 0.56 6.24 0.33 1.38e-9 Interleukin-4 levels; CRC cis rs2976388 0.609 rs2585153 chr8:143785345 G/A cg15511327 chr8:143859410 LYNX1 0.42 7.31 0.37 1.98e-12 Urinary tract infection frequency; CRC cis rs28595532 0.920 rs17325192 chr4:119780345 A/G cg21605333 chr4:119757512 SEC24D -0.69 -6.73 -0.35 7.77e-11 Cannabis dependence symptom count; CRC cis rs2976388 0.578 rs13254358 chr8:143823876 G/A cg22687807 chr8:143858763 LYNX1 -0.45 -6.98 -0.36 1.68e-11 Urinary tract infection frequency; CRC cis rs1552244 1.000 rs6804473 chr3:10060425 C/T cg16606324 chr3:10149918 C3orf24 0.69 9.39 0.46 1.02e-18 Alzheimer's disease; CRC cis rs55882075 0.808 rs6867806 chr5:179179585 C/G cg14593053 chr5:179126677 CANX 0.5 7.99 0.4 2.23e-14 Monocyte percentage of white cells; CRC cis rs67311347 0.869 rs9832311 chr3:40381322 A/T cg24209194 chr3:40518798 ZNF619 0.41 6.04 0.32 4.22e-9 Renal cell carcinoma; CRC cis rs10540 1.000 rs61876333 chr11:487136 G/A cg08200582 chr11:442649 ANO9 -0.68 -6.49 -0.34 3.09e-10 Body mass index; CRC cis rs7923609 1.000 rs7070296 chr10:65070438 T/A cg08743896 chr10:65200160 JMJD1C -0.41 -5.94 -0.31 7.07e-9 Educational attainment;Liver enzyme levels (alkaline phosphatase); CRC cis rs9916302 0.904 rs4511574 chr17:37532916 A/G cg15445000 chr17:37608096 MED1 0.39 8.73 0.43 1.3e-16 Glomerular filtration rate (creatinine); CRC cis rs6714710 0.603 rs12988571 chr2:98405695 C/T cg26665480 chr2:98280029 ACTR1B 0.51 7.01 0.36 1.39e-11 Posterior cortical atrophy and Alzheimer's disease; CRC cis rs1552244 1.000 rs9820598 chr3:10117912 C/G cg10729496 chr3:10149963 C3orf24 0.5 6.81 0.35 4.67e-11 Alzheimer's disease; CRC cis rs11148252 0.811 rs9536030 chr13:52938291 G/A cg00495681 chr13:53174319 NA -0.53 -8.13 -0.41 9e-15 Lewy body disease; CRC cis rs8177253 0.665 rs7646118 chr3:133450039 C/T cg24879335 chr3:133465180 TF 0.37 6.84 0.35 3.9e-11 Iron status biomarkers; CRC cis rs155076 1.000 rs2783107 chr13:21837532 C/A cg25811766 chr13:21894605 NA -0.58 -5.95 -0.31 6.86e-9 White matter hyperintensity burden; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg04622074 chr17:62657955 SMURF2 0.42 6.41 0.33 4.98e-10 Intelligence (multi-trait analysis); CRC cis rs11025559 0.643 rs11025570 chr11:20481109 T/A cg19653624 chr11:20408972 PRMT3 -0.6 -6.28 -0.33 1.05e-9 Pursuit maintenance gain; CRC cis rs9733 0.519 rs7521898 chr1:150707596 G/A cg17724175 chr1:150552817 MCL1 0.58 9.16 0.45 5.58e-18 Tonsillectomy; CRC cis rs17401966 1.000 rs7520935 chr1:10354271 G/T cg19773385 chr1:10388646 KIF1B -0.58 -8.21 -0.41 5.22e-15 Hepatocellular carcinoma; CRC cis rs17401966 0.577 rs6661326 chr1:10242231 T/C cg19773385 chr1:10388646 KIF1B -0.47 -7.25 -0.37 2.92e-12 Hepatocellular carcinoma; CRC trans rs10983614 1.000 rs7867776 chr9:120072627 A/G cg15190599 chr6:26156487 HIST1H1E 0.44 6.31 0.33 9.08e-10 Survival in pancreatic cancer; CRC cis rs17401966 0.838 rs4846207 chr1:10313811 T/C cg19773385 chr1:10388646 KIF1B -0.68 -11.19 -0.52 7.82e-25 Hepatocellular carcinoma; CRC cis rs7666738 0.925 rs2865952 chr4:99040305 C/T cg03676636 chr4:99064102 C4orf37 0.24 6.83 0.35 4.19e-11 Colonoscopy-negative controls vs population controls; CRC cis rs394563 0.726 rs6906384 chr6:149664540 G/A cg16235748 chr6:149772707 ZC3H12D 0.38 6.95 0.36 1.94e-11 Dupuytren's disease; CRC cis rs9309711 0.560 rs6548164 chr2:3472665 C/T cg15541040 chr2:3486749 NA 0.42 6.53 0.34 2.44e-10 Neurofibrillary tangles; CRC trans rs4853036 0.586 rs2312551 chr2:70007357 C/T cg14633329 chr9:139640053 LCN6 -0.39 -6.42 -0.33 4.63e-10 Colorectal or endometrial cancer; CRC cis rs12497850 0.931 rs4974087 chr3:48919232 A/G cg20833759 chr3:49053208 WDR6;DALRD3 0.54 9.34 0.46 1.46e-18 Parkinson's disease; CRC cis rs6570726 0.755 rs451699 chr6:145830594 C/G cg23711669 chr6:146136114 FBXO30 0.74 12.97 0.58 2.27e-31 Lobe attachment (rater-scored or self-reported); CRC cis rs870825 0.616 rs28524599 chr4:185647414 A/G cg04058563 chr4:185651563 MLF1IP 0.72 9.3 0.46 2.04e-18 Blood protein levels; CRC cis rs6479527 0.904 rs1418251 chr9:96848077 T/C cg14459158 chr9:96720562 NA 0.42 7.2 0.37 4.15e-12 Esophageal adenocarcinoma; CRC cis rs7914558 1.000 rs2275271 chr10:104814162 T/C cg04362960 chr10:104952993 NT5C2 0.6 9.04 0.45 1.38e-17 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs10504229 1.000 rs17805332 chr8:58169798 A/G cg02725872 chr8:58115012 NA -0.39 -6.66 -0.34 1.14e-10 Developmental language disorder (linguistic errors); CRC cis rs6448317 0.954 rs12186333 chr4:24919774 T/C cg21108841 chr4:24914750 CCDC149 -0.46 -5.97 -0.31 5.98e-9 Heschl's gyrus morphology; CRC cis rs10504229 1.000 rs60454728 chr8:58173781 G/A cg05313129 chr8:58192883 C8orf71 -0.47 -6.99 -0.36 1.49e-11 Developmental language disorder (linguistic errors); CRC cis rs68170813 0.559 rs80341862 chr7:106934731 C/G cg02696742 chr7:106810147 HBP1 -0.63 -6.96 -0.36 1.88e-11 Coronary artery disease; CRC cis rs11764590 0.715 rs11766468 chr7:2082604 G/A cg21155852 chr7:2048760 MAD1L1 -0.44 -5.83 -0.31 1.3e-8 Neuroticism; CRC cis rs7173389 0.560 rs7174643 chr15:73680301 A/C cg01796676 chr15:73680284 NA 0.55 8.62 0.43 2.79e-16 Resting heart rate; CRC cis rs8058578 1.000 rs3747481 chr16:30666367 C/T cg00531865 chr16:30841666 NA -0.46 -6.0 -0.31 5.11e-9 Multiple myeloma; CRC cis rs17767392 0.958 rs35051046 chr14:71849308 T/C cg13720639 chr14:72061746 SIPA1L1 -0.55 -6.91 -0.36 2.6e-11 Mitral valve prolapse; CRC cis rs17384381 0.953 rs12120551 chr1:85810903 T/C cg16011679 chr1:85725395 C1orf52 0.66 6.72 0.35 7.79e-11 Lobe attachment (rater-scored or self-reported); CRC cis rs8023845 1.000 rs3759843 chr15:40453075 A/G cg20259534 chr15:40453036 BUB1B -0.52 -6.03 -0.32 4.36e-9 Chronic lymphocytic leukemia; CRC trans rs8002861 0.967 rs9533689 chr13:44480413 A/C cg17145862 chr1:211918768 LPGAT1 0.77 15.93 0.66 9.13e-43 Leprosy; CRC cis rs1577917 1.000 rs7766645 chr6:86622238 T/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.51 -6.86 -0.35 3.34e-11 Response to antipsychotic treatment; CRC cis rs2832191 0.933 rs2832236 chr21:30547602 C/T cg08807101 chr21:30365312 RNF160 -0.54 -8.43 -0.42 1.07e-15 Dental caries; CRC cis rs3764563 1.000 rs4371280 chr19:15715768 A/C cg20725493 chr19:15740067 CYP4F8 -0.68 -6.23 -0.32 1.45e-9 Inflammatory biomarkers; CRC cis rs727563 0.593 rs132770 chr22:42017264 A/G cg06634786 chr22:41940651 POLR3H 0.62 6.34 0.33 7.55e-10 Crohn's disease;Inflammatory bowel disease; CRC trans rs2840044 1.000 rs9891800 chr17:33895015 G/C cg19694781 chr19:47549865 TMEM160 0.44 6.94 0.36 2.1e-11 Response to radiotherapy in cancer (late toxicity); CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg23397278 chr11:64051699 GPR137;BAD -0.47 -5.97 -0.31 6.08e-9 Diisocyanate-induced asthma; CRC cis rs7927771 1.000 rs35624992 chr11:47615798 G/C cg05585544 chr11:47624801 NA -0.62 -11.41 -0.53 1.22e-25 Subjective well-being; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg04402966 chr7:87505783 SLC25A40;DBF4 0.42 6.09 0.32 3.2e-9 Anxiety disorder; CRC cis rs9300255 0.602 rs2695476 chr12:123694206 T/C cg00376283 chr12:123451042 ABCB9 0.58 6.83 0.35 4.16e-11 Neutrophil percentage of white cells; CRC cis rs9303280 0.837 rs907092 chr17:37922259 A/G cg11212589 chr17:38028394 ZPBP2 -0.35 -6.28 -0.33 1.07e-9 Self-reported allergy; CRC cis rs6456156 0.819 rs4709148 chr6:167521676 T/C cg07513332 chr6:167530253 CCR6 0.42 7.57 0.39 3.78e-13 Primary biliary cholangitis; CRC cis rs4665809 0.627 rs35461456 chr2:26482361 C/G cg25036284 chr2:26402008 FAM59B 0.62 7.86 0.4 5.64e-14 Gut microbiome composition (summer); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg15204119 chr19:10613180 KEAP1 0.42 6.72 0.35 8.24e-11 Liver disease severity in Alagille syndrome; CRC cis rs9359856 0.636 rs3748085 chr6:90315789 C/T cg13799429 chr6:90582589 CASP8AP2 -0.57 -7.57 -0.38 3.88e-13 Bipolar disorder; CRC cis rs4862750 0.872 rs7679956 chr4:187900229 C/T cg24874828 chr4:187887005 NA -0.37 -6.39 -0.33 5.82e-10 Lobe attachment (rater-scored or self-reported); CRC cis rs1448094 0.967 rs7312144 chr12:86328256 T/C cg02569458 chr12:86230093 RASSF9 0.37 6.47 0.34 3.47e-10 Major depressive disorder; CRC cis rs4555082 0.874 rs2816626 chr14:105735425 G/A cg10792982 chr14:105748885 BRF1 0.38 6.3 0.33 9.39e-10 Mean platelet volume;Platelet distribution width; CRC cis rs1957429 0.901 rs1957435 chr14:65349697 G/A cg23373153 chr14:65346875 NA 0.79 8.25 0.41 3.9e-15 Pediatric areal bone mineral density (radius); CRC cis rs11212617 0.840 rs228599 chr11:108107660 G/A cg01991180 chr11:108092276 ATM;NPAT 0.41 5.89 0.31 9.33e-9 Response to metformin in type 2 diabetes (glycemic); CRC cis rs9611565 0.503 rs5751156 chr22:42170025 A/G cg06481639 chr22:41940642 POLR3H 0.56 6.12 0.32 2.68e-9 Vitiligo; CRC cis rs7487637 0.529 rs11168244 chr12:48202941 C/T cg14736327 chr12:48174669 SLC48A1 -0.58 -7.77 -0.39 9.85e-14 Mononucleosis; CRC cis rs2535633 0.661 rs4515041 chr3:52996032 T/A cg15147215 chr3:52552868 STAB1 0.43 6.98 0.36 1.59e-11 Body mass index; CRC cis rs57221529 0.766 rs4957053 chr5:575927 T/C cg14541582 chr5:601475 NA -0.37 -7.13 -0.37 6.35e-12 Lung disease severity in cystic fibrosis; CRC trans rs963731 0.649 rs10172714 chr2:39197543 C/G cg13401531 chr11:70333281 SHANK2 0.72 6.09 0.32 3.08e-9 Corticobasal degeneration; CRC cis rs4853012 0.941 rs2421752 chr2:74341615 A/G cg05890377 chr2:74357713 NA 0.62 9.8 0.48 4.65e-20 Gestational age at birth (maternal effect); CRC cis rs9733 0.540 rs4971041 chr1:150537357 C/T cg18016565 chr1:150552671 MCL1 -0.47 -7.04 -0.36 1.12e-11 Tonsillectomy; CRC cis rs11971779 0.680 rs7792752 chr7:139066196 G/C cg07862535 chr7:139043722 LUC7L2 0.57 7.35 0.38 1.61e-12 Diisocyanate-induced asthma; CRC cis rs4319547 0.656 rs7975747 chr12:122816995 C/T cg05707623 chr12:122985044 ZCCHC8 -0.69 -8.35 -0.42 1.89e-15 Body mass index; CRC cis rs9435341 0.762 rs72697623 chr1:107554269 G/A cg09367891 chr1:107599246 PRMT6 0.61 8.83 0.44 6.14e-17 Facial morphology (factor 21, depth of nasal alae); CRC cis rs3741151 0.773 rs17244602 chr11:73219907 A/G cg17517138 chr11:73019481 ARHGEF17 -0.82 -7.24 -0.37 3.19e-12 GIP levels in response to oral glucose tolerance test (120 minutes); CRC cis rs765787 0.556 rs2413778 chr15:45539397 C/A cg24006582 chr15:45444508 DUOX1 -0.57 -8.63 -0.43 2.62e-16 Uric acid levels; CRC cis rs72781680 0.948 rs72790326 chr2:24126153 C/T cg08917208 chr2:24149416 ATAD2B 0.9 9.14 0.45 6.81e-18 Lymphocyte counts; CRC cis rs4700695 0.841 rs251306 chr5:65252453 C/T cg21114390 chr5:65439923 SFRS12 0.57 6.88 0.35 3.05e-11 Facial morphology (factor 19); CRC cis rs10479542 0.784 rs4701132 chr5:178985270 A/G cg05457628 chr5:178986728 RUFY1 -0.43 -7.32 -0.37 1.96e-12 Lung cancer; CRC trans rs1864729 0.591 rs2635139 chr8:98301557 A/G cg08679828 chr8:102218111 ZNF706 -0.48 -6.18 -0.32 1.91e-9 Estradiol plasma levels (breast cancer); CRC cis rs7940866 0.809 rs2324317 chr11:130877142 T/C cg12179176 chr11:130786555 SNX19 0.58 8.33 0.42 2.27e-15 Schizophrenia; CRC cis rs1552244 1.000 rs6786638 chr3:10118075 G/C cg10729496 chr3:10149963 C3orf24 0.55 7.26 0.37 2.73e-12 Alzheimer's disease; CRC trans rs629535 0.862 rs655028 chr8:70049047 T/C cg21567404 chr3:27674614 NA 0.95 16.08 0.66 2.35e-43 Dupuytren's disease; CRC cis rs68170813 0.559 rs79026644 chr7:107031803 A/G cg02696742 chr7:106810147 HBP1 -0.62 -6.72 -0.35 8.06e-11 Coronary artery disease; CRC cis rs9393692 0.620 rs6908402 chr6:26293014 A/T cg00631329 chr6:26305371 NA -0.54 -9.36 -0.46 1.26e-18 Educational attainment; CRC cis rs11809207 0.574 rs2783630 chr1:26504741 G/A cg24519413 chr1:26490540 NA 0.36 5.93 0.31 7.53e-9 Height; CRC cis rs9341808 0.754 rs6916405 chr6:81024188 C/T cg08355045 chr6:80787529 NA 0.35 5.63 0.3 3.93e-8 Sitting height ratio; CRC cis rs9346649 0.654 rs12527055 chr6:168492655 C/T cg02770688 chr6:168491649 NA 0.61 8.73 0.43 1.27e-16 Venous thromboembolism adjusted for sickle cell variant rs77121243-T; CRC cis rs7224685 0.501 rs1878332 chr17:3904446 G/A cg21851534 chr17:3907994 ZZEF1 0.37 6.31 0.33 9.02e-10 Type 2 diabetes; CRC cis rs4713118 0.629 rs149899 chr6:28019979 C/T cg03623178 chr6:28175578 NA 0.88 12.69 0.57 2.62e-30 Parkinson's disease; CRC cis rs853679 0.517 rs9393887 chr6:28059020 G/A cg25164649 chr6:28176230 NA 0.73 9.22 0.45 3.66e-18 Depression; CRC cis rs7666738 0.830 rs6833822 chr4:98951354 G/A cg05340658 chr4:99064831 C4orf37 0.61 9.54 0.47 3.45e-19 Colonoscopy-negative controls vs population controls; CRC cis rs2303745 0.589 rs8103523 chr19:17398269 A/G cg04248312 chr19:17393744 ANKLE1 -0.95 -14.15 -0.62 7.69e-36 Systemic lupus erythematosus; CRC cis rs1348850 0.914 rs12616443 chr2:178315751 A/G cg02961200 chr2:178257176 LOC100130691;AGPS 0.58 8.41 0.42 1.27e-15 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg23706441 chr14:104181929 XRCC3;ZFYVE21 0.44 6.06 0.32 3.63e-9 Response to antipsychotic treatment; CRC cis rs4332037 0.539 rs55993248 chr7:2071132 A/G cg25834613 chr7:1915315 MAD1L1 -0.42 -6.1 -0.32 3.06e-9 Bipolar disorder; CRC cis rs2857891 1.000 rs72845397 chr11:6950903 C/T cg17958423 chr11:6947583 ZNF215 0.53 5.63 0.3 3.81e-8 Response to cytadine analogues (cytosine arabinoside); CRC cis rs28386778 0.897 rs57108948 chr17:61802378 T/C cg06601766 chr17:61851465 DDX42;CCDC47 0.44 5.97 0.31 6.3e-9 Prudent dietary pattern; CRC cis rs875971 0.660 rs10272357 chr7:66063074 G/A cg18876405 chr7:65276391 NA -0.61 -11.07 -0.52 1.96e-24 Aortic root size; CRC cis rs1348850 0.914 rs3813259 chr2:178257214 G/A cg02961200 chr2:178257176 LOC100130691;AGPS 0.61 9.16 0.45 5.52e-18 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs1129187 0.967 rs3805952 chr6:42937126 C/T cg21280719 chr6:42927975 GNMT -0.44 -9.57 -0.47 2.56e-19 Alzheimer's disease in APOE e4+ carriers; CRC trans rs4650994 0.544 rs2761469 chr1:178590638 A/C cg05059571 chr16:84539110 KIAA1609 0.57 7.73 0.39 1.31e-13 HDL cholesterol levels;HDL cholesterol; CRC cis rs9916302 0.861 rs9903363 chr17:37499604 C/G cg03013999 chr17:37608204 MED1 -0.48 -7.48 -0.38 6.82e-13 Glomerular filtration rate (creatinine); CRC cis rs4588572 0.643 rs10942857 chr5:77760241 A/G cg11446398 chr5:77624930 NA 0.47 6.29 0.33 1.03e-9 Triglycerides; CRC cis rs6964587 1.000 rs2269727 chr7:91752690 C/A cg17063962 chr7:91808500 NA 0.84 14.73 0.63 4.33e-38 Breast cancer; CRC cis rs250677 0.798 rs11168080 chr5:148409821 C/T cg23229984 chr5:148520753 ABLIM3 0.52 6.71 0.35 8.42e-11 Breast cancer; CRC cis rs858239 1.000 rs199351 chr7:23300049 A/C cg00469287 chr7:23338798 C7orf30 0.46 6.2 0.32 1.69e-9 Cerebrospinal fluid biomarker levels; CRC cis rs7044106 0.791 rs4836829 chr9:123482747 C/T cg14255062 chr9:123606675 PSMD5;LOC253039 0.49 7.26 0.37 2.77e-12 Hip circumference adjusted for BMI; CRC cis rs2882667 0.858 rs7724108 chr5:138410922 A/G cg04439458 chr5:138467593 SIL1 0.35 6.03 0.32 4.33e-9 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs12893668 0.603 rs12896171 chr14:104135966 A/G cg08213375 chr14:104286397 PPP1R13B 0.43 6.83 0.35 4.21e-11 Reticulocyte count; CRC cis rs2011503 0.882 rs4808933 chr19:19363812 T/A cg11584989 chr19:19387371 SF4 0.48 5.99 0.31 5.51e-9 Bipolar disorder; CRC cis rs17376456 0.877 rs7736620 chr5:93305762 C/T cg25358565 chr5:93447407 FAM172A 1.05 10.89 0.51 8.72e-24 Diabetic retinopathy; CRC cis rs7615952 0.599 rs16834938 chr3:125706046 C/T cg05084668 chr3:125655381 ALG1L -0.45 -6.58 -0.34 1.82e-10 Blood pressure (smoking interaction); CRC cis rs9467711 0.606 rs9379901 chr6:26603866 T/C cg12315302 chr6:26189340 HIST1H4D 0.81 6.23 0.32 1.45e-9 Autism spectrum disorder or schizophrenia; CRC cis rs9894429 0.634 rs9709130 chr17:79583948 C/T cg21984481 chr17:79567631 NPLOC4 -0.45 -7.77 -0.39 9.99e-14 Eye color traits; CRC cis rs9796 0.870 rs7169375 chr15:41311046 A/G cg18705301 chr15:41695430 NDUFAF1 -0.37 -6.1 -0.32 3.01e-9 Menopause (age at onset); CRC cis rs3733585 0.673 rs9993410 chr4:9951264 C/T cg00071950 chr4:10020882 SLC2A9 -0.56 -9.8 -0.48 4.63e-20 Cleft plate (environmental tobacco smoke interaction); CRC cis rs1401999 1.000 rs6443926 chr3:183706630 A/C cg05044414 chr3:183734942 ABCC5 0.46 8.03 0.4 1.72e-14 Anterior chamber depth; CRC cis rs28386778 0.897 rs2727327 chr17:61923422 G/A cg23090583 chr17:61904693 PSMC5;FTSJ3 1.04 19.76 0.74 7.57e-58 Prudent dietary pattern; CRC cis rs9309711 0.623 rs7569694 chr2:3483390 T/G cg08493051 chr2:3487164 NA -0.39 -5.71 -0.3 2.53e-8 Neurofibrillary tangles; CRC cis rs2204008 0.540 rs1283306 chr12:38153778 C/A cg13010199 chr12:38710504 ALG10B -0.42 -6.08 -0.32 3.27e-9 Bladder cancer; CRC cis rs738322 0.870 rs2277844 chr22:38577515 G/A cg17652424 chr22:38574118 PLA2G6 0.21 6.68 0.35 1.01e-10 Cutaneous nevi; CRC cis rs9649213 0.593 rs12728 chr7:97922851 C/T cg24562669 chr7:97807699 LMTK2 0.47 7.88 0.4 4.83e-14 Prostate cancer (SNP x SNP interaction); CRC cis rs10450586 0.863 rs10437623 chr11:27307247 C/T cg10370305 chr11:27303972 NA 0.37 6.02 0.31 4.69e-9 Total body bone mineral density; CRC cis rs736408 0.688 rs2239551 chr3:52818579 A/G cg18099408 chr3:52552593 STAB1 0.44 7.0 0.36 1.48e-11 Bipolar disorder; CRC cis rs12134245 0.747 rs11164929 chr1:92012836 G/C cg02896835 chr1:92012615 NA -0.7 -13.04 -0.58 1.34e-31 Breast cancer; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg10800280 chr6:36646508 CDKN1A 0.39 6.21 0.32 1.62e-9 Liver disease severity in Alagille syndrome; CRC cis rs3768617 0.510 rs10911247 chr1:183076993 A/G ch.1.3577855R chr1:183094577 LAMC1 0.84 14.14 0.61 8.51e-36 Fuchs's corneal dystrophy; CRC cis rs1552244 1.000 rs66797209 chr3:10078526 G/A cg02579736 chr3:10068473 FANCD2;CIDECP 1.05 14.06 0.61 1.71e-35 Alzheimer's disease; CRC cis rs9837602 0.529 rs1688774 chr3:99521108 C/T cg08350549 chr3:99591722 C3orf26;FILIP1L;MIR548G -0.38 -5.91 -0.31 8.35e-9 Breast cancer; CRC cis rs6582630 0.555 rs10880602 chr12:38505660 T/C cg26384229 chr12:38710491 ALG10B 0.69 9.84 0.48 3.41e-20 Drug-induced liver injury (flucloxacillin); CRC trans rs2280018 0.526 rs2941257 chr16:15166445 T/C cg04146151 chr16:2155961 PKD1 -0.47 -6.26 -0.33 1.17e-9 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid);Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CRC cis rs1552244 1.000 rs7648104 chr3:10073311 C/A cg00166722 chr3:10149974 C3orf24 0.71 9.49 0.46 4.86e-19 Alzheimer's disease; CRC cis rs6938 0.534 rs1130741 chr15:75189930 A/G cg05627522 chr15:75251581 NA 0.38 5.83 0.31 1.33e-8 Breast cancer; CRC cis rs10992471 0.603 rs10761155 chr9:95153729 C/G cg14631576 chr9:95140430 CENPP -0.38 -6.53 -0.34 2.49e-10 Visceral adipose tissue/subcutaneous adipose tissue ratio; CRC cis rs1451375 0.572 rs3807558 chr7:50571022 A/G cg18232548 chr7:50535776 DDC -0.43 -5.67 -0.3 3.18e-8 Malaria; CRC cis rs9992667 0.744 rs7657152 chr4:38641936 G/T cg19726192 chr4:38663646 FLJ13197 -0.67 -8.73 -0.43 1.31e-16 Eosinophil percentage of granulocytes; CRC cis rs875971 0.545 rs2460427 chr7:65619205 T/C cg02869306 chr7:64672164 INTS4L1 0.43 6.23 0.32 1.43e-9 Aortic root size; CRC cis rs9902453 0.967 rs12450441 chr17:28495021 G/A cg26525008 chr17:28256777 EFCAB5;SSH2 0.58 9.14 0.45 6.58e-18 Coffee consumption (cups per day); CRC cis rs6570726 0.755 rs2092296 chr6:145893684 A/C cg23711669 chr6:146136114 FBXO30 0.69 11.52 0.54 4.94e-26 Lobe attachment (rater-scored or self-reported); CRC cis rs7786877 0.723 rs62482239 chr7:100217810 C/T cg20848291 chr7:100343083 ZAN -0.54 -6.7 -0.35 9.02e-11 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs644799 0.965 rs11021305 chr11:95498269 A/G cg25478527 chr11:95522999 CEP57;FAM76B 0.54 7.94 0.4 3.33e-14 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs2797160 1.000 rs1739371 chr6:126011291 G/A cg05901451 chr6:126070800 HEY2 0.41 6.2 0.32 1.66e-9 Endometrial cancer; CRC trans rs2303319 0.582 rs16845851 chr2:162295623 A/C cg26623550 chr1:112281629 C1orf183 -0.81 -6.06 -0.32 3.73e-9 Cognitive function; CRC cis rs2295359 0.892 rs10789224 chr1:67605134 C/T cg17031739 chr1:67600172 NA -0.4 -6.46 -0.34 3.69e-10 Psoriasis; CRC cis rs2463822 0.920 rs28678254 chr11:62151875 G/C cg06239285 chr11:62104954 ASRGL1 -0.99 -10.78 -0.51 2.03e-23 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs225245 0.782 rs225272 chr17:33969911 T/C cg05299278 chr17:33885742 SLFN14 0.49 8.07 0.41 1.3e-14 Reticulocyte count;Reticulocyte fraction of red cells;High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells; CRC cis rs35272691 1 rs35272691 chr17:38157841 T/C cg17344932 chr17:38183730 MED24;SNORD124 0.85 16.3 0.67 3.43e-44 White blood cell count (neutrophil); CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg20183778 chr7:102105344 ALKBH4;LRWD1 0.51 7.12 0.37 6.99e-12 Anxiety disorder; CRC cis rs7677751 0.806 rs7689569 chr4:55096398 G/A cg13615338 chr4:55094005 PDGFRA 0.4 5.83 0.31 1.35e-8 Corneal astigmatism; CRC cis rs172166 0.694 rs203877 chr6:28048624 T/C cg02631126 chr6:28058918 ZSCAN12L1 0.24 5.67 0.3 3.09e-8 Cardiac Troponin-T levels; CRC cis rs66573146 0.572 rs67252699 chr4:6946411 A/G cg26116260 chr4:7069785 GRPEL1 -0.59 -5.65 -0.3 3.54e-8 Granulocyte percentage of myeloid white cells; CRC cis rs3540 0.512 rs3930162 chr15:91075129 C/T cg22089800 chr15:90895588 ZNF774 -0.55 -8.95 -0.44 2.69e-17 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; CRC cis rs7909074 0.509 rs2026427 chr10:45389704 T/C cg04218760 chr10:45406644 TMEM72 -0.3 -7.37 -0.38 1.43e-12 Mean corpuscular volume; CRC cis rs67478160 0.608 rs11160760 chr14:104248938 G/T cg01849466 chr14:104193079 ZFYVE21 -0.49 -8.66 -0.43 2.21e-16 Schizophrenia; CRC cis rs3785574 0.962 rs8079161 chr17:61808561 C/G cg11494091 chr17:61959527 GH2 0.38 5.83 0.31 1.35e-8 Height; CRC cis rs7568458 0.709 rs1446669 chr2:85762209 T/C cg02493740 chr2:85810744 VAMP5 -0.48 -7.39 -0.38 1.18e-12 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); CRC cis rs10870270 1.000 rs11146338 chr10:133770291 C/G cg08754478 chr10:133766260 PPP2R2D -0.66 -9.29 -0.46 2.22e-18 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; CRC cis rs4363385 0.791 rs372490 chr1:153008971 A/G cg25856811 chr1:152973957 SPRR3 -0.25 -6.99 -0.36 1.51e-11 Inflammatory skin disease; CRC cis rs936229 0.871 rs2290574 chr15:75135447 T/C cg10253484 chr15:75165896 SCAMP2 -0.42 -6.01 -0.31 4.82e-9 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); CRC cis rs8060686 0.858 rs1476306 chr16:67973171 C/T cg07125278 chr16:67683757 RLTPR -0.46 -5.95 -0.31 6.69e-9 HDL cholesterol;Metabolic syndrome; CRC cis rs1499614 1.000 rs2707832 chr7:66136549 C/T cg18252515 chr7:66147081 NA -1.25 -15.27 -0.64 3.51e-40 Gout; CRC cis rs9291683 0.588 rs12507330 chr4:10002195 G/A cg00071950 chr4:10020882 SLC2A9 0.6 11.33 0.53 2.35e-25 Bone mineral density; CRC cis rs6665290 0.904 rs6684821 chr1:227190233 G/A cg10327440 chr1:227177885 CDC42BPA -1.03 -22.36 -0.78 5.29e-68 Myeloid white cell count; CRC cis rs7619833 0.512 rs7634574 chr3:27223319 C/A cg02860705 chr3:27208620 NA 0.38 5.91 0.31 8.51e-9 Breast cancer; CRC cis rs2019137 0.967 rs895412 chr2:113973964 T/C cg12889195 chr2:113992843 PAX8;LOC440839;LOC654433 -0.52 -7.41 -0.38 1.09e-12 Lymphocyte counts; CRC cis rs2857891 0.817 rs2638096 chr11:6977916 T/A cg04053776 chr11:6947353 ZNF215 0.41 5.88 0.31 1.01e-8 Response to cytadine analogues (cytosine arabinoside); CRC cis rs155076 0.711 rs9550724 chr13:21885030 G/T cg06138931 chr13:21896616 NA 0.51 6.44 0.33 4.32e-10 White matter hyperintensity burden; CRC cis rs2179367 0.959 rs514839 chr6:149648440 A/T cg07828024 chr6:149772892 ZC3H12D -0.37 -5.9 -0.31 9.13e-9 Dupuytren's disease; CRC cis rs3733585 0.648 rs13103497 chr4:9979262 A/G cg00071950 chr4:10020882 SLC2A9 0.55 9.76 0.47 6.28e-20 Cleft plate (environmental tobacco smoke interaction); CRC cis rs9329289 0.550 rs11251294 chr10:2562328 C/T cg05625103 chr10:2543513 NA -0.41 -6.47 -0.34 3.61e-10 Age-related hearing impairment; CRC cis rs4474465 0.850 rs4285892 chr11:78243134 C/A cg02023728 chr11:77925099 USP35 -0.37 -6.3 -0.33 9.63e-10 Alzheimer's disease (survival time); CRC cis rs1832871 0.672 rs9456286 chr6:158734315 A/G cg07165851 chr6:158734300 TULP4 0.63 7.94 0.4 3.14e-14 Height; CRC cis rs10504229 0.728 rs17215676 chr8:58152915 G/T cg02290350 chr8:58132656 NA -0.51 -6.57 -0.34 1.98e-10 Developmental language disorder (linguistic errors); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg08492707 chr21:34696952 IFNAR1 0.43 6.74 0.35 7.21e-11 Liver disease severity in Alagille syndrome; CRC cis rs2721195 0.967 rs1985022 chr8:145684031 C/T cg11211951 chr8:145729740 GPT 0.41 7.07 0.36 9.33e-12 Age at first birth; CRC cis rs2249694 1.000 rs1952467 chr10:135353499 T/G cg16964102 chr10:135390573 NA -0.38 -6.21 -0.32 1.57e-9 Obesity-related traits; CRC cis rs6545883 0.929 rs2256615 chr2:61679894 C/G cg15711740 chr2:61764176 XPO1 -0.44 -5.81 -0.31 1.45e-8 Tuberculosis; CRC cis rs8060686 0.565 rs8057577 chr16:68033143 C/T cg26727032 chr16:67993705 SLC12A4 -0.58 -6.39 -0.33 5.67e-10 HDL cholesterol;Metabolic syndrome; CRC cis rs10751667 0.600 rs10751665 chr11:941300 G/A cg06064525 chr11:970664 AP2A2 -0.33 -6.71 -0.35 8.44e-11 Alzheimer's disease (late onset); CRC cis rs10504229 1.000 rs17217033 chr8:58180061 G/T cg01721255 chr8:58191610 C8orf71 0.49 6.17 0.32 2e-9 Developmental language disorder (linguistic errors); CRC cis rs12580194 1.000 rs4262806 chr12:55711562 T/A cg19537932 chr12:55886519 OR6C68 -0.6 -8.23 -0.41 4.29e-15 Cancer; CRC cis rs4474465 0.688 rs7940720 chr11:78276674 C/T cg27205649 chr11:78285834 NARS2 0.5 6.47 0.34 3.52e-10 Alzheimer's disease (survival time); CRC cis rs2692947 0.644 rs1724125 chr2:96831355 G/A cg23100626 chr2:96804247 ASTL 0.3 7.83 0.4 6.61e-14 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; CRC cis rs10504229 0.953 rs67677367 chr8:58175264 T/G cg02290350 chr8:58132656 NA -0.42 -5.96 -0.31 6.62e-9 Developmental language disorder (linguistic errors); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg18043455 chr3:127771761 SEC61A1 0.43 6.2 0.32 1.68e-9 Intelligence (multi-trait analysis); CRC cis rs477692 0.563 rs12266634 chr10:131412659 G/C cg05714579 chr10:131428358 MGMT -0.91 -14.66 -0.63 8.16e-38 Response to temozolomide; CRC cis rs8060686 0.641 rs9938553 chr16:68183064 T/A cg26727032 chr16:67993705 SLC12A4 -0.57 -7.67 -0.39 2.02e-13 HDL cholesterol;Metabolic syndrome; CRC cis rs2243480 1.000 rs316312 chr7:65596491 T/G cg18252515 chr7:66147081 NA -1.24 -14.68 -0.63 7.09e-38 Diabetic kidney disease; CRC cis rs4713118 0.911 rs9295746 chr6:27730064 T/C cg02683197 chr6:28174875 NA 0.65 7.61 0.39 2.87e-13 Parkinson's disease; CRC cis rs561341 1.000 rs72825712 chr17:30316119 A/T cg23018236 chr17:30244563 NA -0.67 -7.99 -0.4 2.35e-14 Hip circumference adjusted for BMI; CRC cis rs6912958 0.754 rs7762864 chr6:88236213 A/G cg12350822 chr6:88032061 C6orf162;GJB7 -0.36 -6.75 -0.35 6.53e-11 Monocyte percentage of white cells; CRC cis rs1862618 0.713 rs832550 chr5:56182589 C/T cg20203395 chr5:56204925 C5orf35 -0.72 -8.29 -0.42 2.99e-15 Initial pursuit acceleration; CRC cis rs7666738 0.611 rs34982650 chr4:98819530 T/A cg17366294 chr4:99064904 C4orf37 0.43 6.94 0.36 2.11e-11 Colonoscopy-negative controls vs population controls; CRC cis rs7208859 0.623 rs11652358 chr17:29205480 T/C cg01831904 chr17:28903510 LRRC37B2 -0.55 -5.77 -0.3 1.88e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs4481887 0.772 rs4916127 chr1:248466615 A/G cg00666640 chr1:248458726 OR2T12 0.52 9.22 0.45 3.57e-18 Common traits (Other); CRC cis rs4631830 0.720 rs2125771 chr10:51506957 C/T cg20129853 chr10:51489980 NA -0.43 -7.17 -0.37 4.92e-12 Prostate-specific antigen levels; CRC cis rs6662572 0.737 rs6700322 chr1:46409176 G/T cg03123370 chr1:45965343 CCDC163P;MMACHC -0.45 -5.82 -0.31 1.42e-8 Blood protein levels; CRC cis rs12887734 0.546 rs66676135 chr14:104271504 G/A cg01849466 chr14:104193079 ZFYVE21 -0.41 -6.28 -0.33 1.05e-9 Schizophrenia;Autism spectrum disorder or schizophrenia; CRC cis rs6502050 0.835 rs55679819 chr17:80105450 C/T cg19223190 chr17:80058835 NA 0.39 6.29 0.33 1e-9 Life satisfaction; CRC cis rs911555 0.723 rs6575986 chr14:103886671 G/A cg24130564 chr14:104152367 KLC1 -0.43 -5.8 -0.3 1.58e-8 Intelligence (multi-trait analysis); CRC cis rs9311474 0.508 rs1570 chr3:52586682 T/A cg18099408 chr3:52552593 STAB1 -0.48 -8.31 -0.42 2.48e-15 Electroencephalogram traits; CRC cis rs9467711 0.659 rs3823158 chr6:26463271 T/A cg12315302 chr6:26189340 HIST1H4D 0.96 6.61 0.34 1.58e-10 Autism spectrum disorder or schizophrenia; CRC cis rs72781680 0.821 rs72796361 chr2:24160689 A/T cg08917208 chr2:24149416 ATAD2B 0.56 6.78 0.35 5.46e-11 Lymphocyte counts; CRC cis rs45544231 0.521 rs1477074 chr16:52578548 T/C cg09051775 chr16:52580266 TOX3 -0.4 -6.51 -0.34 2.87e-10 Restless legs syndrome; CRC cis rs10540 1.000 rs35255804 chr11:492617 G/A cg21784768 chr11:537496 LRRC56 -0.68 -6.51 -0.34 2.8e-10 Body mass index; CRC cis rs12534701 0.904 rs3817518 chr7:154672809 C/T cg24255201 chr7:154684926 DPP6 0.59 8.68 0.43 1.81e-16 Colorectal cancer (diet interaction); CRC trans rs2797160 0.874 rs58305111 chr6:126008386 G/T cg05039488 chr6:79577232 IRAK1BP1 0.49 7.18 0.37 4.75e-12 Endometrial cancer; CRC cis rs11676348 0.846 rs4674259 chr2:218991005 C/T cg00012203 chr2:219082015 ARPC2 -0.44 -6.49 -0.34 3.21e-10 Ulcerative colitis; CRC cis rs7833986 0.534 rs17759244 chr8:57033768 A/G cg23139584 chr8:56987506 RPS20;SNORD54 0.91 12.31 0.56 6.9e-29 Height; CRC cis rs7605827 0.930 rs1035247 chr2:15617846 T/A cg19274914 chr2:15703543 NA 0.39 5.95 0.31 6.89e-9 Educational attainment (years of education); CRC trans rs1864585 0.520 rs73208789 chr8:10679187 A/G cg26278703 chr11:58910052 FAM111A 0.55 6.38 0.33 5.95e-10 Neutrophil percentage of white cells;Lymphocyte percentage of white cells; CRC cis rs7811142 1.000 rs11764818 chr7:100043055 G/A cg00814883 chr7:100076585 TSC22D4 -0.75 -9.53 -0.47 3.63e-19 Platelet count; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg15042806 chr16:23652268 DCTN5;PALB2 0.45 6.38 0.33 5.98e-10 Response to antipsychotic treatment; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg26250143 chr17:3627045 ITGAE;GSG2 0.4 6.37 0.33 6.38e-10 Liver disease severity in Alagille syndrome; CRC trans rs4130344 0.935 rs4234923 chr4:159688477 A/C cg01113538 chr6:53658866 LRRC1 0.4 5.98 0.31 5.92e-9 Intelligence (multi-trait analysis); CRC cis rs523522 0.962 rs12309824 chr12:120990582 A/C cg27279351 chr12:120934652 DYNLL1 0.76 10.68 0.51 4.7e-23 High light scatter reticulocyte count; CRC cis rs736801 0.780 rs11951091 chr5:131786595 G/A cg00255919 chr5:131827918 IRF1 -0.38 -6.43 -0.33 4.57e-10 Breast cancer;Mosquito bite size; CRC trans rs7618501 0.933 rs1128535 chr3:49866392 C/T cg21582582 chr3:182698605 DCUN1D1 0.54 7.98 0.4 2.43e-14 Intelligence (multi-trait analysis); CRC cis rs847577 0.748 rs940431 chr7:97716495 C/T cg00277769 chr7:97922759 BAIAP2L1 -0.4 -6.78 -0.35 5.43e-11 Breast cancer; CRC cis rs6840360 0.642 rs2053566 chr4:152445831 A/C cg09659197 chr4:152720779 NA 0.33 6.67 0.35 1.08e-10 Intelligence (multi-trait analysis); CRC cis rs9818758 0.607 rs13087930 chr3:48961726 A/G cg00383909 chr3:49044727 WDR6 1.33 12.69 0.57 2.61e-30 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; CRC cis rs12701220 0.817 rs1058727 chr7:1087095 A/G cg02869364 chr7:1081709 C7orf50 -0.48 -6.6 -0.34 1.63e-10 Bronchopulmonary dysplasia; CRC cis rs9527 0.641 rs34130454 chr10:104903638 A/G cg15744005 chr10:104629667 AS3MT -0.31 -6.1 -0.32 3.03e-9 Arsenic metabolism; CRC cis rs4332037 0.539 rs34809719 chr7:2028968 G/T cg25834613 chr7:1915315 MAD1L1 -0.48 -6.76 -0.35 6.3e-11 Bipolar disorder; CRC cis rs6866344 0.697 rs11748495 chr5:178130000 A/G cg03877680 chr5:178157825 ZNF354A -0.76 -10.97 -0.52 4.65e-24 Neutrophil percentage of white cells; CRC cis rs17095355 1.000 rs13377169 chr10:111729414 A/G cg00817464 chr10:111662876 XPNPEP1 -0.6 -8.27 -0.42 3.27e-15 Biliary atresia; CRC cis rs7772486 0.701 rs7772717 chr6:145954854 T/C cg23711669 chr6:146136114 FBXO30 0.76 12.95 0.58 2.82e-31 Lobe attachment (rater-scored or self-reported); CRC cis rs708547 0.624 rs1718886 chr4:57849251 C/T cg25525207 chr4:57843836 C4orf14;POLR2B -0.49 -7.21 -0.37 3.82e-12 Response to bleomycin (chromatid breaks); CRC cis rs60871478 0.636 rs4276575 chr7:900035 C/T cg05535760 chr7:792225 HEATR2 -0.76 -8.77 -0.44 9.63e-17 Cerebrospinal P-tau181p levels; CRC cis rs2204008 0.560 rs4129033 chr12:38301897 A/T cg26384229 chr12:38710491 ALG10B -0.53 -7.69 -0.39 1.74e-13 Bladder cancer; CRC cis rs2739330 0.828 rs4822454 chr22:24255208 G/A cg11905131 chr22:24372483 LOC391322 -0.71 -11.45 -0.53 9.16e-26 Liver enzyme levels (gamma-glutamyl transferase); CRC trans rs875971 0.660 rs2191268 chr7:66110224 C/T cg26918792 chr6:26402310 BTN3A1 -0.39 -6.28 -0.33 1.04e-9 Aortic root size; CRC cis rs7149337 0.933 rs28705789 chr14:51713508 C/T cg18282456 chr14:51561492 TRIM9 0.29 5.71 0.3 2.48e-8 Cancer; CRC cis rs10751667 0.577 rs7946461 chr11:974035 A/G cg23136738 chr11:925521 AP2A2 -0.42 -7.09 -0.36 8.01e-12 Alzheimer's disease (late onset); CRC cis rs501120 1.000 rs607760 chr10:44756236 A/G cg09554077 chr10:44749378 NA 0.89 13.28 0.59 1.58e-32 Coronary artery disease;Coronary heart disease; CRC cis rs921968 0.541 rs2241527 chr2:219537224 A/G cg02176678 chr2:219576539 TTLL4 0.61 9.64 0.47 1.62e-19 Mean corpuscular hemoglobin concentration; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg18604876 chr3:5164258 ARL8B -0.45 -6.52 -0.34 2.66e-10 Myopia (pathological); CRC cis rs2549003 1.000 rs7701588 chr5:131819970 T/C cg21138405 chr5:131827807 IRF1 0.57 11.38 0.53 1.59e-25 Asthma (sex interaction); CRC cis rs875971 0.862 rs4368860 chr7:65608482 C/G cg12463550 chr7:65579703 CRCP -0.53 -7.49 -0.38 6.34e-13 Aortic root size; CRC cis rs4731207 0.651 rs28710776 chr7:124614472 A/G cg23710748 chr7:124431027 NA -0.39 -6.25 -0.33 1.29e-9 Cutaneous malignant melanoma; CRC cis rs9811920 0.638 rs793474 chr3:99544380 C/T cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G 0.45 6.06 0.32 3.76e-9 Axial length; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg05139434 chr1:41328180 CITED4 0.38 6.24 0.33 1.33e-9 Liver disease severity in Alagille syndrome; CRC cis rs2395909 1 rs2395909 chr7:107292663 G/A cg23024343 chr7:107201750 COG5 0.46 7.01 0.36 1.37e-11 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; CRC trans rs916888 0.610 rs199529 chr17:44837217 A/C cg01341218 chr17:43662625 NA 0.76 8.08 0.41 1.22e-14 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs4604732 0.536 rs10925056 chr1:247650472 T/C cg02104434 chr1:247694406 LOC148824;OR2C3 0.57 8.26 0.41 3.67e-15 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CRC cis rs155076 0.666 rs2015241 chr13:21888254 A/G cg25811766 chr13:21894605 NA 0.61 7.23 0.37 3.34e-12 White matter hyperintensity burden; CRC cis rs826838 0.651 rs1843892 chr12:38616965 A/G cg26384229 chr12:38710491 ALG10B 0.54 7.41 0.38 1.08e-12 Heart rate; CRC cis rs6496044 1.000 rs6496044 chr15:86067306 G/A cg17133734 chr15:86042851 AKAP13 0.39 5.93 0.31 7.51e-9 Interstitial lung disease; CRC cis rs2836974 0.932 rs8129416 chr21:40617145 C/T cg06238570 chr21:40685208 BRWD1 0.78 10.83 0.51 1.36e-23 Cognitive function; CRC cis rs11626933 1.000 rs11626016 chr14:90747979 C/T cg14092571 chr14:90743983 NA -0.94 -15.38 -0.65 1.29e-40 Gut microbiota (bacterial taxa); CRC cis rs9910055 0.762 rs184478 chr17:42209751 C/G cg09913183 chr17:42254507 C17orf65;ASB16 -0.58 -8.46 -0.42 9.01e-16 Total body bone mineral density; CRC cis rs12497850 0.897 rs6446252 chr3:48911125 C/T cg20833759 chr3:49053208 WDR6;DALRD3 0.53 9.14 0.45 6.55e-18 Parkinson's disease; CRC cis rs9894429 0.816 rs7406040 chr17:79597583 A/C cg18240062 chr17:79603768 NPLOC4 0.66 11.83 0.55 3.94e-27 Eye color traits; CRC cis rs539514 0.690 rs607095 chr13:76316165 A/T cg04757411 chr13:76259545 LMO7 -0.36 -6.08 -0.32 3.29e-9 Type 1 diabetes; CRC trans rs877282 0.700 rs816311 chr10:796490 C/A cg22713356 chr15:30763199 NA 1.02 12.72 0.57 1.98e-30 Uric acid levels; CRC cis rs780096 0.526 rs704791 chr2:27657167 T/C cg24768116 chr2:27665128 KRTCAP3 -0.36 -8.22 -0.41 4.71e-15 Total body bone mineral density; CRC cis rs975722 0.638 rs718829 chr7:117207860 C/A cg09181792 chr7:117119393 CFTR 0.29 6.04 0.32 4.28e-9 Coronary artery disease; CRC cis rs3785574 0.962 rs2584623 chr17:61906679 G/A cg22520471 chr17:61851767 DDX42;CCDC47 0.47 6.37 0.33 6.35e-10 Height; CRC cis rs13108904 0.935 rs1732100 chr4:1281761 C/T cg19318889 chr4:1322082 MAEA -0.4 -5.95 -0.31 6.8e-9 Obesity-related traits; CRC cis rs2011503 1.000 rs756999 chr19:19448200 A/G cg11584989 chr19:19387371 SF4 -0.47 -5.98 -0.31 5.79e-9 Bipolar disorder; CRC cis rs7666738 0.830 rs4699600 chr4:99019429 C/G cg05340658 chr4:99064831 C4orf37 0.61 9.51 0.46 4.05e-19 Colonoscopy-negative controls vs population controls; CRC cis rs7737355 0.947 rs7706785 chr5:130954860 T/C cg25547332 chr5:131281432 NA 0.4 5.6 0.3 4.43e-8 Life satisfaction; CRC cis rs863345 0.526 rs857724 chr1:158607372 C/T cg12129480 chr1:158549410 OR10X1 -0.29 -6.27 -0.33 1.12e-9 Pneumococcal bacteremia; CRC trans rs3942852 0.955 rs7117386 chr11:48125371 G/A cg03929089 chr4:120376271 NA -0.54 -6.67 -0.35 1.09e-10 Acute lymphoblastic leukemia (childhood); CRC cis rs4555082 0.794 rs2735829 chr14:105708472 C/T cg06808227 chr14:105710500 BRF1 -0.62 -8.92 -0.44 3.42e-17 Mean platelet volume;Platelet distribution width; CRC cis rs7647973 0.593 rs55997059 chr3:49858661 A/T cg03060546 chr3:49711283 APEH -0.65 -8.14 -0.41 8.31e-15 Menarche (age at onset); CRC cis rs9649213 0.555 rs6968193 chr7:97915902 C/T cg21770322 chr7:97807741 LMTK2 0.54 9.03 0.45 1.52e-17 Prostate cancer (SNP x SNP interaction); CRC cis rs10504229 0.683 rs949856 chr8:58144496 G/A cg02290350 chr8:58132656 NA -0.59 -8.33 -0.42 2.25e-15 Developmental language disorder (linguistic errors); CRC cis rs6502050 0.723 rs8077209 chr17:80163221 A/G cg22110888 chr17:80059540 CCDC57 0.39 6.14 0.32 2.34e-9 Life satisfaction; CRC cis rs11021065 0.720 rs11021083 chr11:94952391 G/A cg08881680 chr11:94965469 SESN3 -0.4 -5.63 -0.3 3.83e-8 Common carotid intima-media thickness in HIV infection;Common carotid intima-media thickness; CRC cis rs7945705 0.935 rs2568061 chr11:8886260 A/G cg00186954 chr11:8933980 ST5;C11orf17 -0.45 -7.2 -0.37 4.04e-12 Hemoglobin concentration; CRC cis rs7773004 0.905 rs1053860 chr6:26325228 C/T cg00631329 chr6:26305371 NA -0.4 -6.89 -0.36 2.86e-11 Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for body mass index;Waist circumference adjusted for BMI in non-smokers;Waist circumference adjusted for BMI (adjusted for smoking behaviour); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg20094282 chr17:79369258 NA 0.4 5.96 0.31 6.56e-9 Response to antipsychotic treatment; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg19522332 chr3:178866004 PIK3CA 0.5 6.48 0.34 3.3e-10 Thyroid stimulating hormone; CRC cis rs17376456 0.825 rs12188163 chr5:93250608 A/G cg09848695 chr5:92956644 FAM172A;MIR2277 -0.67 -5.93 -0.31 7.56e-9 Diabetic retinopathy; CRC cis rs7680126 0.596 rs12510549 chr4:10276467 A/G cg00071950 chr4:10020882 SLC2A9 -0.44 -5.94 -0.31 7.08e-9 Urate levels in lean individuals;Urate levels in overweight individuals;Urate levels in obese individuals; CRC cis rs9611565 0.559 rs5751160 chr22:42175695 A/G cg03806693 chr22:41940476 POLR3H 1.09 13.47 0.6 3.05e-33 Vitiligo; CRC cis rs2239547 0.607 rs9836178 chr3:52925403 T/C cg10802521 chr3:52805072 NEK4 0.48 6.45 0.34 3.96e-10 Schizophrenia; CRC cis rs5769707 0.967 rs17182154 chr22:49990470 A/G cg05373962 chr22:49881684 NA -0.35 -6.6 -0.34 1.66e-10 Monocyte count;Monocyte percentage of white cells; CRC cis rs9311474 0.659 rs7638808 chr3:52572056 C/T cg18404041 chr3:52824283 ITIH1 0.32 6.69 0.35 9.39e-11 Electroencephalogram traits; CRC cis rs11146838 1 rs11146838 chr10:39149977 A/T cg00409905 chr10:38381863 ZNF37A -0.56 -8.93 -0.44 2.97e-17 Breast cancer; CRC cis rs1153858 1.000 rs12439274 chr15:45636667 A/G cg21132104 chr15:45694354 SPATA5L1 0.57 8.51 0.42 6.17e-16 Homoarginine levels; CRC cis rs7586879 0.828 rs1968482 chr2:25086858 T/C cg22495460 chr2:25135724 ADCY3 -0.83 -13.94 -0.61 5.1e-35 Body mass index; CRC trans rs916888 0.773 rs199534 chr17:44824213 T/G cg01341218 chr17:43662625 NA 0.98 10.05 0.48 6.69e-21 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs6502050 0.835 rs62078306 chr17:80085341 A/G cg25804541 chr17:80189381 SLC16A3 0.31 5.9 0.31 8.94e-9 Life satisfaction; CRC cis rs4689388 0.889 rs13128674 chr4:6294517 C/T cg14416269 chr4:6271139 WFS1 0.4 6.59 0.34 1.72e-10 Type 2 diabetes and other traits;Type 2 diabetes; CRC cis rs1448094 0.706 rs10863149 chr12:86425498 A/T cg02569458 chr12:86230093 RASSF9 0.47 8.0 0.4 2.15e-14 Major depressive disorder; CRC cis rs853679 0.517 rs1853097 chr6:28058635 A/G cg12273811 chr6:28175739 NA 0.74 9.41 0.46 8.58e-19 Depression; CRC cis rs9807989 0.507 rs4479442 chr2:103054074 A/T cg03938978 chr2:103052716 IL18RAP 0.58 10.15 0.49 3.07e-21 Asthma; CRC trans rs7615952 0.800 rs13086460 chr3:125646417 C/T cg21747405 chr11:67723411 NA -0.45 -6.33 -0.33 8.16e-10 Blood pressure (smoking interaction); CRC cis rs4665809 1.000 rs12475854 chr2:26267375 G/A cg25036284 chr2:26402008 FAM59B -0.44 -5.86 -0.31 1.15e-8 Gut microbiome composition (summer); CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg21826008 chr12:54674368 HNRPA1L-2;HNRNPA1;CBX5 0.47 6.25 0.33 1.25e-9 Thyroid stimulating hormone; CRC cis rs9487051 0.872 rs7773331 chr6:109609208 C/T cg01475377 chr6:109611718 NA -0.49 -9.34 -0.46 1.52e-18 Reticulocyte fraction of red cells; CRC cis rs2842992 0.872 rs2758328 chr6:160090731 T/A cg19482086 chr6:160211437 TCP1;MRPL18 0.68 8.55 0.43 4.71e-16 Age-related macular degeneration (geographic atrophy); CRC cis rs754466 0.651 rs11815015 chr10:79625482 C/T cg17075019 chr10:79541650 NA -0.89 -15.36 -0.65 1.55e-40 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs34526934 0.608 rs7591820 chr2:177028144 G/T cg03152288 chr2:177042942 NA -0.57 -7.37 -0.38 1.4e-12 Obstructive sleep apnea trait (apnea hypopnea index); CRC cis rs28386778 0.897 rs8066754 chr17:61816590 T/C cg22520471 chr17:61851767 DDX42;CCDC47 0.73 11.25 0.53 4.55e-25 Prudent dietary pattern; CRC cis rs4728302 0.869 rs10156088 chr7:133592544 G/A cg03336402 chr7:133662267 EXOC4 -0.45 -6.56 -0.34 2.04e-10 Intelligence;Intelligence (multi-trait analysis); CRC cis rs4713118 0.629 rs203888 chr6:28021589 C/T cg25164649 chr6:28176230 NA 0.63 8.83 0.44 6.21e-17 Parkinson's disease; CRC cis rs524281 0.731 rs10791840 chr11:65803383 T/C cg16950941 chr11:66035639 RAB1B -0.53 -5.81 -0.31 1.45e-8 Electroencephalogram traits; CRC cis rs7666738 0.830 rs4699592 chr4:98974202 A/C cg17366294 chr4:99064904 C4orf37 0.44 7.44 0.38 8.98e-13 Colonoscopy-negative controls vs population controls; CRC cis rs2243480 0.831 rs57294491 chr7:65684901 T/A cg12463550 chr7:65579703 CRCP -0.67 -6.06 -0.32 3.72e-9 Diabetic kidney disease; CRC cis rs6546550 0.867 rs1048266 chr2:70132676 A/G cg02498382 chr2:70120550 SNRNP27 -0.56 -9.52 -0.46 3.78e-19 Prevalent atrial fibrillation; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg27309920 chr12:6798957 ZNF384 0.51 7.48 0.38 7.02e-13 Response to antipsychotic treatment; CRC cis rs73206853 0.841 rs73191834 chr12:110963841 T/G cg12870014 chr12:110450643 ANKRD13A 0.81 8.45 0.42 9.67e-16 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC cis rs524023 1.000 rs10792441 chr11:64360629 C/T cg14139581 chr11:64358342 SLC22A12 -0.38 -6.1 -0.32 3.01e-9 Urate levels in obese individuals; CRC cis rs4728302 0.869 rs7792546 chr7:133595502 G/T cg10665199 chr7:133106180 EXOC4 0.4 6.03 0.32 4.33e-9 Intelligence;Intelligence (multi-trait analysis); CRC cis rs2033711 0.870 rs6510152 chr19:58953319 C/T cg00825309 chr19:58991885 ZNF446 -0.47 -6.72 -0.35 8.22e-11 Uric acid clearance; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg02444243 chr1:61516135 NA 0.44 6.4 0.33 5.22e-10 Intelligence (multi-trait analysis); CRC cis rs1799949 1.000 rs34534709 chr17:41302940 C/G cg23758822 chr17:41437982 NA 0.8 13.44 0.6 3.93e-33 Menopause (age at onset); CRC cis rs11792861 0.926 rs1044905 chr9:111781495 G/A cg05043794 chr9:111880884 C9orf5 -0.35 -6.37 -0.33 6.51e-10 Menarche (age at onset); CRC cis rs9463078 0.605 rs9472416 chr6:44950963 T/C cg25276700 chr6:44698697 NA 0.26 6.31 0.33 9.21e-10 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; CRC cis rs8044995 0.925 rs9928653 chr16:68252079 T/C cg26727032 chr16:67993705 SLC12A4 -0.64 -9.86 -0.48 2.94e-20 Schizophrenia; CRC cis rs9527 0.568 rs12772775 chr10:104702999 C/A cg15744005 chr10:104629667 AS3MT -0.31 -6.23 -0.32 1.41e-9 Arsenic metabolism; CRC trans rs3931020 0.720 rs927904 chr1:75260328 A/G cg19176530 chr2:71295334 NAGK 0.49 6.27 0.33 1.16e-9 Resistin levels; CRC cis rs10267593 0.516 rs62435159 chr7:1911281 G/A cg25834613 chr7:1915315 MAD1L1 -0.4 -6.47 -0.34 3.62e-10 Coronary artery disease; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg10638605 chr10:69991197 ATOH7 0.45 6.32 0.33 8.57e-10 Response to antipsychotic treatment; CRC trans rs3942852 0.955 rs1910364 chr11:48113232 A/G cg03929089 chr4:120376271 NA -0.56 -6.54 -0.34 2.32e-10 Acute lymphoblastic leukemia (childhood); CRC cis rs9487051 0.676 rs6913093 chr6:109636205 T/C cg21918786 chr6:109611834 NA -0.4 -6.89 -0.35 2.9e-11 Reticulocyte fraction of red cells; CRC cis rs4819052 0.851 rs875621 chr21:46682295 A/G cg11663144 chr21:46675770 NA -0.82 -13.88 -0.61 8.55e-35 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC trans rs1814175 0.559 rs1818892 chr11:49863084 C/A cg11707556 chr5:10655725 ANKRD33B -0.52 -10.01 -0.48 9.28e-21 Height; CRC cis rs7843479 0.965 rs11775479 chr8:21859991 C/T cg17168535 chr8:21777572 XPO7 0.55 8.77 0.44 9.97e-17 Mean corpuscular volume; CRC cis rs1538970 0.924 rs11211117 chr1:45930246 C/T cg05343316 chr1:45956843 TESK2 0.72 9.75 0.47 6.62e-20 Platelet count; CRC cis rs45509595 0.822 rs200484 chr6:27775674 A/G cg19041857 chr6:27730383 NA -0.7 -6.61 -0.34 1.51e-10 Breast cancer; CRC cis rs4132509 1.000 rs7514984 chr1:243965623 C/T cg21452805 chr1:244014465 NA 0.48 6.44 0.33 4.2e-10 RR interval (heart rate); CRC cis rs1799949 0.965 rs11654051 chr17:41419656 C/T cg23758822 chr17:41437982 NA 0.81 13.63 0.6 7.36e-34 Menopause (age at onset); CRC cis rs1046896 0.594 rs4075209 chr17:80800027 G/T cg08200770 chr17:80723486 TBCD -0.5 -7.54 -0.38 4.57e-13 Glycated hemoglobin levels; CRC cis rs7552404 0.924 rs1146580 chr1:76209935 T/C cg10523679 chr1:76189770 ACADM 0.78 11.83 0.55 3.97e-27 Blood metabolite levels;Acylcarnitine levels; CRC cis rs780094 0.544 rs780108 chr2:27684957 T/C cg21248554 chr2:27665150 KRTCAP3 -0.29 -6.71 -0.35 8.73e-11 Calcium levels;Fasting blood insulin;Metabolic traits;Triglyceride levels;Fasting plasma glucose;Urate levels in overweight individuals;Urate levels in obese individuals;Uric acid levels;Height;Age-related diseases, mortality and associated endophenotypes;Renal underexcretion gout;Fasting blood glucose (BMI interaction);Urate levels;Gondoic acid (20:1n-9) levels;Fasting blood insulin (BMI interaction);Triglycerides;Plasma omega-3 polyunsaturated fatty acid levels (docosapentaenoic acid);Type 2 diabetes;Nonalcoholic fatty liver disease;Hypertriglyceridemia;C-reactive protein;Age-related disease endophenotypes;LDL cholesterol;Metabolic syndrome;Crohn's disease;Alcohol consumption (drinks per week);Homeostasis model assessment of insulin resistance;Alcohol consumption;Red blood cell count;Fasting blood glucose; CRC trans rs3780486 0.846 rs3780487 chr9:33139237 T/C cg04842962 chr6:43655489 MRPS18A 1.17 25.84 0.82 3.41e-81 IgG glycosylation; CRC cis rs2033711 0.902 rs4801589 chr19:58953398 C/G cg00825309 chr19:58991885 ZNF446 -0.46 -6.63 -0.34 1.34e-10 Uric acid clearance; CRC cis rs6761276 0.868 rs12468224 chr2:113834434 G/C cg24553058 chr2:113831203 IL1F10 0.4 6.44 0.33 4.26e-10 Protein quantitative trait loci; CRC cis rs826838 1.000 rs851934 chr12:39104453 G/T cg13010199 chr12:38710504 ALG10B -0.41 -6.07 -0.32 3.5e-9 Heart rate; CRC trans rs629535 0.773 rs489206 chr8:70064883 T/C cg21567404 chr3:27674614 NA 0.92 15.29 0.64 2.9e-40 Dupuytren's disease; CRC cis rs7932354 0.528 rs1872896 chr11:47160623 C/T cg03339077 chr11:47165057 C11orf49 0.51 7.31 0.37 2.01e-12 Bone mineral density (hip);Bone mineral density; CRC cis rs7208859 0.673 rs11652370 chr17:29097223 G/A cg01831904 chr17:28903510 LRRC37B2 -0.52 -5.99 -0.31 5.39e-9 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs3749237 0.964 rs62260719 chr3:49852419 G/A cg03060546 chr3:49711283 APEH 0.44 6.43 0.33 4.48e-10 Resting heart rate; CRC cis rs10849893 0.538 rs4980986 chr12:121914808 A/T cg01154721 chr12:121881891 KDM2B -0.4 -5.68 -0.3 2.93e-8 Fasting blood glucose;Fasting blood glucose (BMI interaction); CRC cis rs11122272 0.735 rs2244994 chr1:231537127 C/G cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.57 -8.6 -0.43 3.21e-16 Hemoglobin concentration; CRC cis rs17065868 0.649 rs56317250 chr13:45034046 T/C cg10246903 chr13:45222710 NA 0.54 5.69 0.3 2.79e-8 Antineutrophil cytoplasmic antibody-associated vasculitis; CRC cis rs861020 1.000 rs632746 chr1:209982515 C/T cg05527609 chr1:210001259 C1orf107 0.98 12.42 0.56 2.73e-29 Orofacial clefts; CRC cis rs7274811 0.744 rs55651102 chr20:32188068 A/T cg03904042 chr20:32255491 NECAB3;C20orf134 -0.46 -6.37 -0.33 6.45e-10 Height; CRC trans rs1656966 1.000 rs1656966 chr3:186466252 C/T cg26230658 chr17:5372445 DHX33 0.39 5.97 0.31 6.16e-9 Myopia (pathological); CRC cis rs738322 1.000 rs738320 chr22:38568715 G/T cg03162506 chr22:38580953 NA 0.27 5.77 0.3 1.81e-8 Cutaneous nevi; CRC cis rs4925386 0.840 rs6143036 chr20:60921721 C/A cg15193198 chr20:60906057 LAMA5 -0.43 -6.16 -0.32 2.07e-9 Colorectal cancer;Colorectal cancer (SNP x SNP interaction); CRC cis rs11764590 0.715 rs55770986 chr7:2087823 T/C cg21155852 chr7:2048760 MAD1L1 -0.44 -5.8 -0.3 1.59e-8 Neuroticism; CRC cis rs6089584 0.606 rs7270469 chr20:60577258 G/A cg23463467 chr20:60627584 TAF4 0.39 7.67 0.39 1.9e-13 Body mass index; CRC cis rs6696846 0.749 rs7515178 chr1:205084120 G/A cg00857998 chr1:205179979 DSTYK 0.41 5.76 0.3 1.96e-8 Red blood cell count; CRC trans rs7395662 0.517 rs10838960 chr11:48584741 A/G cg15704280 chr7:45808275 SEPT13 -0.48 -6.84 -0.35 3.77e-11 HDL cholesterol; CRC cis rs7572644 0.640 rs4665392 chr2:28029649 A/G cg27432699 chr2:27873401 GPN1 0.46 6.18 0.32 1.87e-9 Response to carboplatin and paclitaxel in ovarian cancer (Caspase 3/7 EC50); CRC cis rs593982 1.000 rs74638829 chr11:65495571 C/T cg08755490 chr11:65554678 OVOL1 -1.08 -12.43 -0.57 2.49e-29 Atopic dermatitis; CRC cis rs4604732 0.527 rs60444724 chr1:247623164 T/G cg02104434 chr1:247694406 LOC148824;OR2C3 0.63 9.19 0.45 4.56e-18 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CRC cis rs6582630 0.502 rs1607876 chr12:38355750 T/C cg13010199 chr12:38710504 ALG10B 0.47 6.37 0.33 6.37e-10 Drug-induced liver injury (flucloxacillin); CRC cis rs4660261 0.561 rs11210934 chr1:44369435 G/A cg13606994 chr1:44402422 ARTN -0.35 -5.93 -0.31 7.86e-9 Intelligence (multi-trait analysis); CRC cis rs1506636 1.000 rs619575 chr7:123393460 C/T cg03229431 chr7:123269106 ASB15 -0.68 -10.63 -0.51 7.18e-23 Plateletcrit;Platelet count; CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg04110283 chr11:17373108 DKFZp686O24166 -0.47 -6.09 -0.32 3.2e-9 Diisocyanate-induced asthma; CRC cis rs919433 0.889 rs788001 chr2:198213720 C/T cg10820045 chr2:198174542 NA 0.46 8.12 0.41 9.32e-15 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC cis rs35146811 0.844 rs10281368 chr7:99655897 A/G cg03265037 chr7:99691720 MIR25;MCM7;MIR106B;MIR93 0.43 5.71 0.3 2.48e-8 Coronary artery disease; CRC cis rs10504229 0.683 rs11786843 chr8:58133629 T/C cg04204079 chr8:58130323 NA -0.45 -5.75 -0.3 2.06e-8 Developmental language disorder (linguistic errors); CRC cis rs8141529 0.748 rs7287918 chr22:29281710 G/A cg15103426 chr22:29168792 CCDC117 0.48 6.59 0.34 1.79e-10 Lymphocyte counts; CRC cis rs7937682 0.883 rs512669 chr11:111467893 G/A cg19812747 chr11:111475976 SIK2 -0.56 -9.52 -0.46 3.81e-19 Primary sclerosing cholangitis; CRC cis rs12497850 0.863 rs4974084 chr3:48939080 G/A cg07636037 chr3:49044803 WDR6 1.03 17.63 0.7 1.83e-49 Parkinson's disease; CRC cis rs6952808 0.636 rs73048162 chr7:1949328 T/C cg22963979 chr7:1858916 MAD1L1 -0.42 -6.58 -0.34 1.87e-10 Bipolar disorder and schizophrenia; CRC cis rs6942756 1.000 rs4440569 chr7:128923907 T/A cg02491457 chr7:128862824 NA -0.77 -10.49 -0.5 2.11e-22 White matter hyperintensity burden; CRC cis rs274567 0.550 rs272885 chr5:131667736 A/G cg04518342 chr5:131593106 PDLIM4 0.43 6.98 0.36 1.62e-11 Blood metabolite levels; CRC cis rs67478160 0.643 rs6575999 chr14:104250609 C/G cg01849466 chr14:104193079 ZFYVE21 -0.5 -8.79 -0.44 8.46e-17 Schizophrenia; CRC cis rs17711722 0.727 rs781151 chr7:65479878 T/C cg05627663 chr7:65219948 SNORA22;CCT6P1 0.43 6.07 0.32 3.47e-9 Calcium levels; CRC cis rs853679 0.599 rs188015 chr6:27877446 T/A cg06470822 chr6:28175283 NA 0.77 6.93 0.36 2.26e-11 Depression; CRC cis rs172166 0.561 rs149971 chr6:27982152 G/A cg21251018 chr6:28226885 NKAPL 0.57 9.86 0.48 2.99e-20 Cardiac Troponin-T levels; CRC cis rs3760982 1.000 rs10405457 chr19:44296582 G/T cg12072164 chr19:44306565 LYPD5 0.37 5.79 0.3 1.68e-8 Breast cancer (estrogen-receptor negative);Breast cancer; CRC cis rs10971721 0.554 rs55917897 chr9:33795950 C/T cg13495928 chr9:33750294 PRSS3 0.67 5.94 0.31 7.14e-9 Body mass index; CRC cis rs4604732 0.588 rs74154678 chr1:247626202 A/T cg02104434 chr1:247694406 LOC148824;OR2C3 0.6 8.85 0.44 5.65e-17 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CRC cis rs9303401 0.659 rs12602808 chr17:56698420 A/G cg02118635 chr17:56770003 RAD51C;TEX14 0.79 9.9 0.48 2.16e-20 Cognitive test performance; CRC cis rs2180341 1.000 rs6569479 chr6:127606588 A/G cg24812749 chr6:127587940 RNF146 0.95 13.64 0.6 7.03e-34 Breast cancer; CRC cis rs9400239 0.622 rs1268167 chr6:109008183 A/G cg11073813 chr6:109029018 NA 0.41 6.46 0.34 3.67e-10 Waist circumference;Body mass index;BMI (adjusted for smoking behaviour); CRC cis rs10504229 1.000 rs72650900 chr8:58185675 T/A cg22535103 chr8:58192502 C8orf71 -0.82 -12.27 -0.56 9.63e-29 Developmental language disorder (linguistic errors); CRC cis rs8141529 0.748 rs5752826 chr22:29269808 A/G cg15103426 chr22:29168792 CCDC117 0.5 6.92 0.36 2.32e-11 Lymphocyte counts; CRC cis rs713587 0.525 rs11675457 chr2:25079770 C/T cg04586622 chr2:25135609 ADCY3 -0.56 -10.49 -0.5 2.11e-22 Body mass index in non-asthmatics; CRC cis rs6988985 0.678 rs7831617 chr8:144002283 G/T cg10324643 chr8:143916377 GML 0.38 6.32 0.33 8.57e-10 Plasma androstenedione levels in resected early stage-receptor positive breast cancer; CRC cis rs727505 1.000 rs6952721 chr7:124480075 T/C cg23710748 chr7:124431027 NA -0.68 -12.27 -0.56 9.04e-29 Lewy body disease; CRC cis rs6752107 1.000 rs2289474 chr2:234181848 C/T cg07618928 chr2:234183455 ATG16L1;SCARNA5 0.67 11.65 0.54 1.73e-26 Crohn's disease;Inflammatory bowel disease; CRC cis rs748404 0.660 rs509306 chr15:43715171 A/G cg15269541 chr15:43626905 ADAL -0.36 -5.64 -0.3 3.7e-8 Lung cancer; CRC trans rs57221529 0.766 rs4081847 chr5:574072 C/T cg11887960 chr12:57824829 NA 0.6 6.78 0.35 5.74e-11 Lung disease severity in cystic fibrosis; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg04592976 chr16:89984572 MC1R 0.48 5.98 0.31 5.81e-9 Thyroid stimulating hormone; CRC cis rs8077889 0.645 rs1230393 chr17:41842592 A/G cg16892393 chr17:41919603 NA -0.38 -5.94 -0.31 7.23e-9 Triglycerides; CRC cis rs17253792 0.822 rs17253744 chr14:56161950 C/G cg01858014 chr14:56050164 KTN1 -0.87 -6.87 -0.35 3.31e-11 Putamen volume; CRC cis rs939584 1.000 rs74676797 chr2:633063 G/A cg03610516 chr2:642275 NA 0.42 5.65 0.3 3.49e-8 Body mass index; CRC cis rs1403694 0.515 rs1656925 chr3:186449123 T/C cg04611788 chr3:186434169 KNG1 -0.58 -8.37 -0.42 1.66e-15 Blood protein levels; CRC cis rs736801 0.607 rs11746555 chr5:131727033 G/A cg00255919 chr5:131827918 IRF1 -0.36 -6.12 -0.32 2.69e-9 Breast cancer;Mosquito bite size; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg05654483 chr10:122610929 WDR11 0.4 6.15 0.32 2.27e-9 Liver disease severity in Alagille syndrome; CRC cis rs11764590 0.694 rs10241537 chr7:2083358 A/G cg25834613 chr7:1915315 MAD1L1 -0.35 -5.86 -0.31 1.1e-8 Neuroticism; CRC cis rs2832077 0.527 rs2705690 chr21:30239245 T/A cg24692254 chr21:30365293 RNF160 0.46 6.67 0.35 1.06e-10 Cognitive test performance; CRC cis rs9928842 0.823 rs8061356 chr16:75294232 G/A cg08657710 chr16:75258780 CTRB1 -0.53 -6.3 -0.33 9.65e-10 Alcoholic chronic pancreatitis; CRC trans rs208520 0.690 rs1304672 chr6:66847973 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 1.08 14.22 0.62 4.24e-36 Exhaled nitric oxide output; CRC cis rs35110281 0.659 rs2236667 chr21:45112939 A/G cg01579765 chr21:45077557 HSF2BP -0.34 -6.59 -0.34 1.78e-10 Mean corpuscular volume; CRC cis rs4689388 0.782 rs4262051 chr4:6281775 G/A cg14416269 chr4:6271139 WFS1 0.4 6.52 0.34 2.61e-10 Type 2 diabetes and other traits;Type 2 diabetes; CRC cis rs1218582 0.774 rs4845680 chr1:154863195 A/G cg03351412 chr1:154909251 PMVK 0.54 8.68 0.43 1.82e-16 Prostate cancer; CRC cis rs17155006 0.655 rs378641 chr7:107722149 C/T cg05962710 chr7:107745446 LAMB4 0.35 5.88 0.31 1.01e-8 Pneumococcal bacteremia; CRC cis rs853679 0.517 rs1947862 chr6:28105196 C/T cg12273811 chr6:28175739 NA 0.74 9.46 0.46 6.29e-19 Depression; CRC cis rs9837602 1.000 rs793499 chr3:99565576 T/C cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G -0.47 -5.71 -0.3 2.51e-8 Breast cancer; CRC cis rs4919694 1.000 rs77827514 chr10:104822009 C/T cg04362960 chr10:104952993 NT5C2 1.11 10.44 0.5 3.09e-22 Arsenic metabolism; CRC cis rs6570726 1.000 rs455109 chr6:145872665 C/T cg05347473 chr6:146136440 FBXO30 0.4 6.23 0.32 1.45e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs2019137 0.560 rs6707386 chr2:113981022 G/A cg25243455 chr2:114033360 PAX8;LOC440839 -0.3 -7.15 -0.37 5.55e-12 Lymphocyte counts; CRC cis rs7224314 0.895 rs11654663 chr17:65389305 A/C cg01507342 chr17:65387096 PITPNC1 -0.54 -8.08 -0.41 1.23e-14 Diisocyanate-induced asthma; CRC cis rs7224737 0.673 rs11079035 chr17:40289012 C/T cg20291162 chr17:40259547 DHX58 -0.45 -6.01 -0.31 4.98e-9 Fibrinogen levels; CRC cis rs453301 0.686 rs11787026 chr8:8902371 A/T cg06636001 chr8:8085503 FLJ10661 0.43 6.83 0.35 4.13e-11 Joint mobility (Beighton score); CRC cis rs2180341 0.538 rs11556354 chr6:127664661 G/A cg24812749 chr6:127587940 RNF146 0.49 7.02 0.36 1.28e-11 Breast cancer; CRC cis rs2565722 0.583 rs2465874 chr6:161298592 G/T cg03159191 chr6:161285451 NA -0.38 -5.87 -0.31 1.07e-8 Blood protein levels; CRC cis rs6502050 0.835 rs8070014 chr17:80115247 T/G cg09264619 chr17:80180166 NA -0.35 -5.97 -0.31 5.98e-9 Life satisfaction; CRC trans rs7819412 0.806 rs6980856 chr8:10938260 A/G cg16141378 chr3:129829833 LOC729375 -0.42 -6.11 -0.32 2.79e-9 Triglycerides; CRC cis rs7727544 0.904 rs7736102 chr5:131604257 G/A cg20512303 chr5:131592959 PDLIM4 0.29 5.68 0.3 2.97e-8 Blood metabolite levels; CRC cis rs10751667 0.961 rs7395303 chr11:986221 T/A ch.11.42038R chr11:967971 AP2A2 0.68 11.33 0.53 2.49e-25 Alzheimer's disease (late onset); CRC cis rs875971 1.000 rs6961717 chr7:65587537 C/T cg00343986 chr7:65444356 GUSB -0.45 -6.63 -0.34 1.4e-10 Aortic root size; CRC cis rs9611565 0.659 rs73178632 chr22:41934573 C/T cg06481639 chr22:41940642 POLR3H -0.54 -6.25 -0.33 1.29e-9 Vitiligo; CRC cis rs1129187 0.755 rs9471985 chr6:42941324 T/C cg05552183 chr6:42928497 GNMT 0.52 7.98 0.4 2.54e-14 Alzheimer's disease in APOE e4+ carriers; CRC cis rs10504229 0.683 rs55868006 chr8:58135703 C/T cg04204079 chr8:58130323 NA -0.45 -5.78 -0.3 1.71e-8 Developmental language disorder (linguistic errors); CRC cis rs477692 1.000 rs473771 chr10:131408155 A/C cg05714579 chr10:131428358 MGMT 0.53 7.88 0.4 4.97e-14 Response to temozolomide; CRC cis rs57221529 0.766 rs56216231 chr5:581193 G/A cg17948913 chr5:572064 NA 0.56 6.29 0.33 1e-9 Lung disease severity in cystic fibrosis; CRC cis rs7647973 0.922 rs7620024 chr3:49451691 G/A cg07690219 chr3:49449608 TCTA;RHOA 0.5 5.62 0.3 3.98e-8 Menarche (age at onset); CRC cis rs4523957 0.890 rs8076939 chr17:2099931 C/A cg16513277 chr17:2031491 SMG6 -0.56 -9.35 -0.46 1.4e-18 Autism spectrum disorder or schizophrenia;Schizophrenia; CRC trans rs7726839 0.540 rs7558 chr5:660491 C/T cg25482853 chr8:67687455 SGK3 1.11 13.02 0.58 1.5e-31 Obesity-related traits; CRC cis rs5750830 0.649 rs4821895 chr22:39823015 A/G cg24399712 chr22:39784796 NA -0.51 -10.6 -0.5 8.6e-23 Intelligence (multi-trait analysis); CRC cis rs875971 0.505 rs1167385 chr7:65513308 G/A cg18912574 chr7:65842487 NCRNA00174 -0.35 -6.03 -0.32 4.52e-9 Aortic root size; CRC cis rs6499244 0.510 rs68039170 chr16:69886089 T/C cg15192750 chr16:69999425 NA 0.39 5.73 0.3 2.22e-8 Menarche (age at onset); CRC cis rs1008375 1.000 rs1974624 chr4:17650281 A/G cg02297831 chr4:17616191 MED28 0.49 6.62 0.34 1.46e-10 Parasitemia in Tripanosoma cruzi seropositivity; CRC trans rs993804 0.527 rs7630907 chr3:25122044 G/C cg12730826 chr1:205179972 DSTYK -0.47 -6.02 -0.31 4.75e-9 Bipolar disorder and schizophrenia; CRC cis rs4713118 0.513 rs149945 chr6:28002853 T/C cg12273811 chr6:28175739 NA 0.55 8.14 0.41 8.09e-15 Parkinson's disease; CRC cis rs6840360 0.642 rs7684462 chr4:152348422 T/G cg09659197 chr4:152720779 NA 0.34 6.67 0.35 1.06e-10 Intelligence (multi-trait analysis); CRC cis rs798554 0.679 rs2266922 chr7:2824707 G/A cg13628971 chr7:2884303 GNA12 0.44 6.8 0.35 5.03e-11 Height; CRC cis rs3814231 0.589 rs12357967 chr10:115469710 G/A cg24846397 chr10:115438155 CASP7 -0.35 -5.68 -0.3 2.9e-8 Vitiligo; CRC cis rs9916302 0.706 rs9944459 chr17:37484185 T/C cg15445000 chr17:37608096 MED1 -0.34 -6.04 -0.32 4.2e-9 Glomerular filtration rate (creatinine); CRC cis rs62244186 0.659 rs56234157 chr3:44516221 G/A cg18165381 chr3:44552316 NA -0.39 -5.88 -0.31 1.02e-8 Depressive symptoms; CRC trans rs7267979 1.000 rs6050561 chr20:25334855 C/T cg17903999 chr18:56338584 MALT1 0.43 7.08 0.36 8.61e-12 Liver enzyme levels (alkaline phosphatase); CRC cis rs2797160 1.000 rs2211418 chr6:125995503 G/A cg05901451 chr6:126070800 HEY2 -0.43 -6.6 -0.34 1.65e-10 Endometrial cancer; CRC cis rs644799 0.965 rs598876 chr11:95560853 A/G cg03916912 chr11:95522834 CEP57;FAM76B 0.95 18.38 0.71 2.03e-52 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs9914988 0.943 rs28847895 chr17:27172520 T/C cg16670446 chr17:27188758 MIR451;MIR144 0.6 9.95 0.48 1.44e-20 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs7811142 0.830 rs7341507 chr7:99951315 A/G cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.08 15.69 0.65 8.17e-42 Platelet count; CRC cis rs4443100 0.535 rs13055979 chr22:23474085 C/T cg14186256 chr22:23484241 RTDR1 0.57 7.59 0.39 3.38e-13 Serum parathyroid hormone levels; CRC cis rs17095355 1.000 rs4565840 chr10:111717140 A/G cg00817464 chr10:111662876 XPNPEP1 -0.61 -8.29 -0.42 2.98e-15 Biliary atresia; CRC cis rs473651 0.777 rs550890 chr2:239332555 G/A cg21699342 chr2:239360505 ASB1 0.48 7.59 0.39 3.38e-13 Multiple system atrophy; CRC cis rs9487051 0.735 rs882074 chr6:109611720 C/T cg12927641 chr6:109611667 NA -0.37 -6.72 -0.35 8.01e-11 Reticulocyte fraction of red cells; CRC cis rs769267 0.930 rs10282 chr19:19619317 T/C cg02546618 chr19:19431379 KIAA0892;SF4 0.44 6.08 0.32 3.33e-9 Tonsillectomy; CRC cis rs9649213 0.593 rs6969234 chr7:97987986 T/C cg24562669 chr7:97807699 LMTK2 0.44 7.29 0.37 2.39e-12 Prostate cancer (SNP x SNP interaction); CRC trans rs747334 0.818 rs3981165 chr10:92704909 C/T cg19856520 chr1:39696676 MACF1 -0.32 -5.99 -0.31 5.45e-9 Fibroblast growth factor basic levels; CRC cis rs3924048 0.574 rs11121925 chr1:12613130 A/C cg00291366 chr1:12616550 NA 0.6 10.86 0.51 1.1e-23 Optic cup area; CRC cis rs62244186 0.659 rs9850129 chr3:44532047 C/T cg10263370 chr3:44754102 ZNF502 -0.37 -6.04 -0.32 4.08e-9 Depressive symptoms; CRC cis rs9611565 0.877 rs3817999 chr22:41747717 A/G cg06634786 chr22:41940651 POLR3H 0.42 5.71 0.3 2.54e-8 Vitiligo; CRC cis rs2836974 0.602 rs8130854 chr21:40707041 G/A cg17971929 chr21:40555470 PSMG1 -0.66 -9.62 -0.47 1.89e-19 Cognitive function; CRC cis rs3767633 0.925 rs10733044 chr1:161903534 A/G cg09175582 chr1:161736000 ATF6 -0.61 -5.77 -0.3 1.85e-8 IgG glycosylation; CRC cis rs754466 0.651 rs56138814 chr10:79625795 T/C cg26805224 chr10:79626177 DLG5 -0.56 -8.34 -0.42 2.12e-15 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs747650 0.504 rs7108822 chr11:47044355 G/A cg19486271 chr11:47235900 DDB2 -0.44 -5.9 -0.31 9.01e-9 Acne (severe); CRC cis rs4555082 0.750 rs2816650 chr14:105708343 C/T cg06808227 chr14:105710500 BRF1 -0.6 -8.61 -0.43 3.02e-16 Mean platelet volume;Platelet distribution width; CRC cis rs7666738 0.830 rs17558193 chr4:99049593 A/G cg05340658 chr4:99064831 C4orf37 0.6 9.35 0.46 1.4e-18 Colonoscopy-negative controls vs population controls; CRC cis rs2288073 0.965 rs6545340 chr2:24422269 C/G cg06627628 chr2:24431161 ITSN2 -0.71 -9.84 -0.48 3.41e-20 Venous thromboembolism (SNP x SNP interaction); CRC cis rs1448094 0.520 rs12304244 chr12:86272823 C/T cg19622623 chr12:86230825 RASSF9 -0.42 -6.56 -0.34 2.11e-10 Major depressive disorder; CRC trans rs116095464 0.614 rs62344339 chr5:252995 T/G cg00938859 chr5:1591904 SDHAP3 0.73 7.89 0.4 4.53e-14 Breast cancer; CRC cis rs629535 0.773 rs630235 chr8:70033529 T/G cg26132723 chr8:70041827 NA 0.35 5.72 0.3 2.41e-8 Dupuytren's disease; CRC cis rs4969178 0.965 rs8077859 chr17:76386335 C/T cg05887092 chr17:76393375 PGS1 0.55 10.01 0.48 8.86e-21 HDL cholesterol levels; CRC cis rs10256972 0.630 rs13235747 chr7:1129123 T/C cg07308232 chr7:1071921 C7orf50 -0.46 -6.2 -0.32 1.69e-9 Longevity;Endometriosis; CRC cis rs6691722 0.503 rs1064842 chr1:24706269 A/G cg02336364 chr1:24764700 NIPAL3 0.38 6.34 0.33 7.51e-10 Response to interferon beta in multiple sclerosis; CRC cis rs9814567 0.574 rs7650509 chr3:134170971 C/T cg06109529 chr3:134205091 CEP63;ANAPC13 0.55 8.17 0.41 6.68e-15 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs4927850 0.723 rs7630825 chr3:195753740 T/C cg01181863 chr3:195395398 SDHAP2 -0.66 -9.84 -0.48 3.34e-20 Pancreatic cancer; CRC cis rs10193935 1.000 rs12612527 chr2:42392099 T/C cg27598129 chr2:42591480 NA -0.71 -7.28 -0.37 2.54e-12 Colonoscopy-negative controls vs population controls; CRC cis rs3858526 0.642 rs55732658 chr11:5894602 A/C cg26762873 chr11:5879799 OR52E8 -0.46 -6.53 -0.34 2.46e-10 DNA methylation (variation); CRC cis rs4927850 1.000 rs4927850 chr3:195751630 C/T cg01181863 chr3:195395398 SDHAP2 0.55 7.63 0.39 2.5e-13 Pancreatic cancer; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg16551665 chr17:30814028 CDK5R1 0.46 6.56 0.34 2.05e-10 Response to antipsychotic treatment; CRC cis rs11203032 0.831 rs11203028 chr10:90956550 C/T cg16672925 chr10:90967113 CH25H 0.45 5.74 0.3 2.17e-8 Heart failure; CRC cis rs9322193 0.962 rs9688940 chr6:150110113 G/A cg05861140 chr6:150128134 PCMT1 -0.43 -7.05 -0.36 1.03e-11 Lung cancer; CRC cis rs6502050 0.835 rs3935403 chr17:80114145 C/T cg11859384 chr17:80120422 CCDC57 -0.37 -5.96 -0.31 6.44e-9 Life satisfaction; CRC cis rs2976388 0.587 rs2717606 chr8:143799496 G/A cg04969067 chr8:143858791 LYNX1 0.44 7.43 0.38 9.31e-13 Urinary tract infection frequency; CRC cis rs7607369 0.648 rs7559629 chr2:219657013 A/T cg02176678 chr2:219576539 TTLL4 -0.56 -8.96 -0.44 2.44e-17 Red blood cell count;Amyotrophic lateral sclerosis; CRC cis rs3857536 0.741 rs2097679 chr6:66937994 T/C cg07460842 chr6:66804631 NA -0.43 -5.81 -0.3 1.48e-8 Blood trace element (Cu levels); CRC cis rs773506 0.628 rs10733739 chr9:93929515 C/T cg14446406 chr9:93919335 NA -0.45 -7.71 -0.39 1.49e-13 Type 2 diabetes nephropathy; CRC cis rs9368481 0.554 rs2754603 chr6:26965139 T/C cg07220782 chr6:26987966 LOC100270746;C6orf41 -0.41 -5.8 -0.3 1.59e-8 Autism spectrum disorder or schizophrenia; CRC cis rs853679 0.513 rs13437444 chr6:28070998 C/T cg15845792 chr6:28175446 NA 0.92 9.45 0.46 6.58e-19 Depression; CRC cis rs7927771 0.864 rs755554 chr11:47432034 G/C cg05585544 chr11:47624801 NA 0.47 8.2 0.41 5.54e-15 Subjective well-being; CRC cis rs875971 0.862 rs10256544 chr7:65675128 A/G cg11764359 chr7:65958608 NA 0.6 9.37 0.46 1.21e-18 Aortic root size; CRC cis rs909341 0.537 rs11696871 chr20:62387417 C/T cg14758556 chr20:62440591 NA 0.41 6.15 0.32 2.23e-9 Atopic dermatitis; CRC cis rs559928 0.606 rs61083753 chr11:63892665 C/T cg19465662 chr11:63993652 NUDT22;TRPT1 0.6 5.97 0.31 6.22e-9 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; CRC cis rs10911232 0.507 rs4651138 chr1:183001312 C/A ch.1.3577855R chr1:183094577 LAMC1 0.84 14.65 0.63 9e-38 Hypertriglyceridemia; CRC cis rs6456156 0.846 rs10946211 chr6:167515489 G/A cg05540913 chr6:167530185 CCR6 -0.34 -5.85 -0.31 1.2e-8 Primary biliary cholangitis; CRC cis rs7618915 0.501 rs34754793 chr3:52629177 A/T cg18099408 chr3:52552593 STAB1 -0.48 -8.1 -0.41 1.06e-14 Bipolar disorder; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg04622074 chr17:62657955 SMURF2 0.45 6.13 0.32 2.52e-9 Anxiety disorder; CRC cis rs769267 0.930 rs2301786 chr19:19413947 A/G cg03709012 chr19:19516395 GATAD2A 0.7 10.72 0.51 3.35e-23 Tonsillectomy; CRC cis rs3799977 0.531 rs62436031 chr6:44722203 A/G cg25276700 chr6:44698697 NA 0.31 7.79 0.39 8.85e-14 Attention deficit hyperactivity disorder; CRC cis rs11212617 0.967 rs227066 chr11:108209199 C/T cg12106634 chr11:108092400 ATM;NPAT 0.39 5.6 0.3 4.44e-8 Response to metformin in type 2 diabetes (glycemic); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg11507343 chr20:18447757 C20orf12;POLR3F 0.42 5.96 0.31 6.43e-9 Response to antipsychotic treatment; CRC cis rs7617480 0.648 rs6766238 chr3:48801929 G/A cg20833759 chr3:49053208 WDR6;DALRD3 0.74 11.35 0.53 1.96e-25 Subjective well-being (multi-trait analysis);Menarche (age at onset); CRC cis rs9891119 0.965 rs8072391 chr17:40495390 G/A cg06270615 chr17:40516068 STAT3 -0.26 -5.75 -0.3 2.04e-8 Multiple sclerosis;Crohn's disease; CRC cis rs863345 0.604 rs4276920 chr1:158504972 G/C cg12129480 chr1:158549410 OR10X1 -0.3 -6.25 -0.33 1.3e-9 Pneumococcal bacteremia; CRC cis rs9457247 1.000 rs393558 chr6:167397750 A/C cg23791538 chr6:167370224 RNASET2 -0.38 -5.94 -0.31 7.32e-9 Crohn's disease; CRC cis rs514406 0.861 rs2065477 chr1:53250213 C/T cg08859206 chr1:53392774 SCP2 -0.42 -6.38 -0.33 5.89e-10 Monocyte count; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg09254969 chr5:141303622 KIAA0141 0.37 6.04 0.32 4.09e-9 Liver disease severity in Alagille syndrome; CRC cis rs2075371 0.966 rs2544214 chr7:133985736 G/A cg02659138 chr7:134003124 SLC35B4 0.37 6.41 0.33 5.15e-10 Mean platelet volume; CRC cis rs9443645 0.869 rs9443626 chr6:79629564 G/C cg11833968 chr6:79620685 NA -0.35 -6.05 -0.32 3.91e-9 Intelligence (multi-trait analysis); CRC cis rs6952808 0.609 rs12699453 chr7:1953056 C/T cg00106254 chr7:1943704 MAD1L1 -0.37 -5.81 -0.31 1.46e-8 Bipolar disorder and schizophrenia; CRC cis rs7605827 0.930 rs6715487 chr2:15540579 T/C cg19274914 chr2:15703543 NA 0.39 5.93 0.31 7.81e-9 Educational attainment (years of education); CRC cis rs6582630 0.537 rs10785436 chr12:38461040 G/C cg13010199 chr12:38710504 ALG10B 0.49 6.64 0.34 1.27e-10 Drug-induced liver injury (flucloxacillin); CRC cis rs394563 0.726 rs6906384 chr6:149664540 G/A cg17885791 chr6:149771845 ZC3H12D 0.32 5.87 0.31 1.04e-8 Dupuytren's disease; CRC cis rs6662572 0.737 rs74523130 chr1:46599619 C/T cg03123370 chr1:45965343 CCDC163P;MMACHC 0.49 6.24 0.33 1.32e-9 Blood protein levels; CRC cis rs9368481 0.761 rs4358615 chr6:26998567 A/G cg18867708 chr6:26865862 GUSBL1 0.39 5.84 0.31 1.26e-8 Autism spectrum disorder or schizophrenia; CRC cis rs11212617 0.934 rs595747 chr11:108194073 C/T cg01991180 chr11:108092276 ATM;NPAT 0.41 5.91 0.31 8.63e-9 Response to metformin in type 2 diabetes (glycemic); CRC cis rs7917772 0.503 rs1409310 chr10:104282265 T/C cg22532475 chr10:104410764 TRIM8 -0.36 -6.79 -0.35 5.16e-11 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC cis rs9905704 0.846 rs304268 chr17:56799907 T/C cg12560992 chr17:57184187 TRIM37 0.54 7.92 0.4 3.75e-14 Testicular germ cell tumor; CRC cis rs11098499 0.954 rs6849171 chr4:120409549 G/A cg09307838 chr4:120376055 NA 0.72 11.24 0.53 5.13e-25 Corneal astigmatism; CRC cis rs2836950 0.565 rs2836934 chr21:40564885 A/C cg17971929 chr21:40555470 PSMG1 -0.58 -8.48 -0.42 7.96e-16 Menarche (age at onset); CRC cis rs9914988 0.673 rs9890212 chr17:27169890 G/C cg07195577 chr17:27052828 TLCD1 0.39 5.63 0.3 3.87e-8 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs2204008 0.623 rs1607878 chr12:38376000 A/G cg26384229 chr12:38710491 ALG10B 0.67 9.94 0.48 1.55e-20 Bladder cancer; CRC cis rs853679 0.517 rs3734573 chr6:28059437 T/C cg12172441 chr6:28176163 NA 0.62 7.38 0.38 1.28e-12 Depression; CRC cis rs2046867 0.774 rs62249873 chr3:72907115 G/A cg25664220 chr3:72788482 NA -0.44 -6.15 -0.32 2.3e-9 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; CRC cis rs9916302 0.784 rs34473775 chr17:37396201 G/T cg07936489 chr17:37558343 FBXL20 -0.79 -11.88 -0.55 2.58e-27 Glomerular filtration rate (creatinine); CRC cis rs1670533 1.000 rs2290410 chr4:1052078 A/T cg27284194 chr4:1044797 NA 0.5 6.1 0.32 2.99e-9 Recombination rate (females); CRC cis rs875971 0.862 rs6460279 chr7:65662761 T/C cg12463550 chr7:65579703 CRCP -0.5 -6.75 -0.35 6.76e-11 Aortic root size; CRC cis rs9914544 0.966 rs7210746 chr17:18798593 T/C cg26306683 chr17:18585705 ZNF286B 0.49 7.0 0.36 1.47e-11 Educational attainment (years of education); CRC cis rs12692738 0.526 rs355846 chr2:165624586 C/T cg03182029 chr2:165697222 COBLL1 -0.5 -5.81 -0.31 1.45e-8 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);Waist-to-hip ratio adjusted for BMI in non-smokers;Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction);Waist-to-hip ratio adjusted for body mass index; CRC cis rs868943 0.714 rs1999930 chr6:116387134 C/T cg26893134 chr6:116381904 FRK 0.27 6.5 0.34 3.06e-10 Total cholesterol levels; CRC cis rs6500602 0.634 rs2270365 chr16:4526758 G/A cg08645402 chr16:4508243 NA 0.63 11.16 0.52 9.56e-25 Schizophrenia; CRC cis rs6951245 1.000 rs80094748 chr7:1103958 G/A cg21664854 chr7:1097933 C7orf50;GPR146 0.77 8.78 0.44 9.31e-17 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs7786877 0.521 rs2293767 chr7:100361675 A/G cg20848291 chr7:100343083 ZAN 0.58 8.64 0.43 2.56e-16 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC trans rs3733585 0.699 rs6852441 chr4:9973744 C/T cg26043149 chr18:55253948 FECH -0.5 -7.57 -0.39 3.73e-13 Cleft plate (environmental tobacco smoke interaction); CRC cis rs9291683 0.588 rs3733586 chr4:9997534 C/T cg11266682 chr4:10021025 SLC2A9 0.52 11.16 0.52 9.91e-25 Bone mineral density; CRC cis rs9527 0.571 rs3740400 chr10:104629465 T/G cg08772003 chr10:104629869 AS3MT -0.35 -5.81 -0.31 1.48e-8 Arsenic metabolism; CRC cis rs6695640 0.854 rs1075535 chr1:17739820 T/C cg10329579 chr1:17754830 RCC2 -0.31 -5.73 -0.3 2.26e-8 Mean platelet volume; CRC cis rs2882667 0.898 rs10038121 chr5:138389602 A/G cg04439458 chr5:138467593 SIL1 -0.34 -6.13 -0.32 2.45e-9 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs72945132 0.882 rs7932431 chr11:70166059 A/T cg00319359 chr11:70116639 PPFIA1 0.67 7.46 0.38 7.95e-13 Coronary artery disease; CRC cis rs7605827 0.930 rs4668905 chr2:15543776 C/A cg19274914 chr2:15703543 NA 0.4 5.92 0.31 8.18e-9 Educational attainment (years of education); CRC cis rs3820068 0.705 rs2145397 chr1:15896199 G/A cg27534772 chr1:16042836 PLEKHM2 0.43 7.07 0.36 9.17e-12 Systolic blood pressure; CRC cis rs2108622 0.559 rs7252638 chr19:15981025 G/C cg13772218 chr19:15982569 NA 0.48 6.81 0.35 4.52e-11 Circulating phylloquinone levels;Vitamin E levels;Acenocoumarol maintenance dosage;Response to Vitamin E supplementation;Metabolite levels;Warfarin maintenance dose; CRC cis rs6951245 0.938 rs117729148 chr7:1108531 G/A cg18402987 chr7:1209562 NA 0.67 7.17 0.37 4.89e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs7692995 0.920 rs35613046 chr4:18005966 A/G cg08925142 chr4:18023851 LCORL -0.55 -6.06 -0.32 3.73e-9 Height; CRC cis rs4718428 1.000 rs4718428 chr7:66421446 T/G cg00343986 chr7:65444356 GUSB 0.43 5.78 0.3 1.7e-8 Corneal structure; CRC cis rs6860806 0.507 rs156322 chr5:131653925 C/T cg12564285 chr5:131593104 PDLIM4 0.45 7.35 0.38 1.61e-12 Breast cancer; CRC cis rs709400 0.628 rs3783394 chr14:103858673 G/A cg12935359 chr14:103987150 CKB -0.51 -7.57 -0.39 3.75e-13 Body mass index; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg27343303 chr11:34380546 NA 0.46 6.2 0.32 1.65e-9 Thyroid stimulating hormone; CRC cis rs6558530 0.666 rs6558523 chr8:1702504 T/C cg19131313 chr8:1704013 NA -0.49 -6.05 -0.32 3.98e-9 Systolic blood pressure; CRC cis rs7772486 0.806 rs7740785 chr6:146171299 C/A cg05347473 chr6:146136440 FBXO30 0.37 5.71 0.3 2.55e-8 Lobe attachment (rater-scored or self-reported); CRC cis rs9611565 0.802 rs2234058 chr22:41777883 G/A cg03806693 chr22:41940476 POLR3H -1.08 -13.76 -0.6 2.34e-34 Vitiligo; CRC cis rs2073499 0.935 rs74398439 chr3:50331927 C/T cg09545109 chr3:50388910 TUSC4;CYB561D2 0.62 5.64 0.3 3.66e-8 Schizophrenia; CRC cis rs425277 0.583 rs12059660 chr1:2041461 C/T cg19257562 chr1:2043853 PRKCZ 0.38 6.42 0.33 4.67e-10 Height; CRC cis rs651907 0.535 rs58658478 chr3:101511667 G/A cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.61 7.99 0.4 2.36e-14 Colorectal cancer; CRC cis rs6964587 0.839 rs13246743 chr7:91453945 G/T cg17063962 chr7:91808500 NA 0.67 10.61 0.51 7.91e-23 Breast cancer; CRC cis rs11148252 0.904 rs3892337 chr13:53029485 C/G cg00495681 chr13:53174319 NA 0.66 10.3 0.49 9.66e-22 Lewy body disease; CRC cis rs8077889 0.672 rs2106764 chr17:41852717 T/A cg26893861 chr17:41843967 DUSP3 1.07 20.49 0.75 9.97e-61 Triglycerides; CRC cis rs58799304 0.531 rs74965833 chr1:156054119 C/T cg15685922 chr1:156045208 MEX3A -0.52 -8.65 -0.43 2.38e-16 Ischemic stroke; CRC trans rs1864585 0.520 rs17774398 chr8:10632496 A/G cg26278703 chr11:58910052 FAM111A -0.49 -6.39 -0.33 5.72e-10 Neutrophil percentage of white cells;Lymphocyte percentage of white cells; CRC cis rs4889911 0.544 rs2587498 chr17:77830737 G/A cg00646381 chr17:77835854 NA 0.42 6.63 0.34 1.39e-10 Electroencephalogram traits; CRC cis rs4713118 0.869 rs9283881 chr6:27715255 A/T cg19041857 chr6:27730383 NA -0.41 -5.96 -0.31 6.46e-9 Parkinson's disease; CRC cis rs7258465 1.000 rs4808136 chr19:18618867 A/G cg06462663 chr19:18546047 ISYNA1 -0.46 -6.97 -0.36 1.77e-11 Breast cancer; CRC cis rs2153535 0.580 rs6597332 chr6:8504748 C/G cg07606381 chr6:8435919 SLC35B3 0.65 10.55 0.5 1.36e-22 Motion sickness; CRC cis rs853679 0.760 rs11962305 chr6:28199937 G/C cg15845792 chr6:28175446 NA 0.76 7.99 0.4 2.34e-14 Depression; CRC cis rs13108904 0.901 rs7673398 chr4:1300077 G/A cg02018176 chr4:1364513 KIAA1530 0.39 6.56 0.34 2.07e-10 Obesity-related traits; CRC cis rs6076065 0.723 rs6137922 chr20:23363773 G/A cg11657817 chr20:23433608 CST11 0.46 6.82 0.35 4.42e-11 Facial morphology (factor 15, philtrum width); CRC cis rs11690935 0.959 rs1113389 chr2:172635365 C/T cg13550731 chr2:172543902 DYNC1I2 -1.09 -18.51 -0.71 6.56e-53 Schizophrenia; CRC cis rs7772486 0.790 rs2485632 chr6:146193228 A/G cg13319975 chr6:146136371 FBXO30 -0.46 -6.95 -0.36 2.01e-11 Lobe attachment (rater-scored or self-reported); CRC cis rs668210 0.793 rs534201 chr11:65776728 A/T cg02202077 chr11:65769826 EIF1AD;BANF1 0.48 6.33 0.33 7.91e-10 Cerebrospinal fluid biomarker levels; CRC cis rs9916302 0.904 rs13341996 chr17:37536862 C/T cg03013999 chr17:37608204 MED1 -0.47 -7.31 -0.37 2.09e-12 Glomerular filtration rate (creatinine); CRC trans rs877282 0.898 rs12358966 chr10:758703 A/G cg22713356 chr15:30763199 NA 1.23 15.06 0.64 2.44e-39 Uric acid levels; CRC cis rs12477438 0.501 rs13000731 chr2:99795231 G/T cg14399236 chr2:99771627 LIPT1;TSGA10 0.73 12.17 0.56 2.24e-28 Chronic sinus infection; CRC cis rs60871478 0.578 rs62432900 chr7:826794 G/C cg05535760 chr7:792225 HEATR2 1.03 13.47 0.6 2.98e-33 Cerebrospinal P-tau181p levels; CRC trans rs10805346 0.501 rs4604059 chr4:10115065 C/T cg26043149 chr18:55253948 FECH -0.43 -6.12 -0.32 2.71e-9 Urate levels in overweight individuals;Urate levels in obese individuals; CRC cis rs713587 0.626 rs62140636 chr2:25233811 T/C cg04586622 chr2:25135609 ADCY3 0.35 6.05 0.32 3.95e-9 Body mass index in non-asthmatics; CRC cis rs3087591 0.960 rs12943508 chr17:29599954 C/G cg24425628 chr17:29625626 OMG;NF1 0.85 16.59 0.67 2.5e-45 Hip circumference; CRC cis rs4820539 1.000 rs4822357 chr22:23473231 A/G cg14186256 chr22:23484241 RTDR1 0.91 17.31 0.69 3.58e-48 Bone mineral density; CRC cis rs10504229 0.683 rs903706 chr8:58128134 T/G cg02290350 chr8:58132656 NA -0.58 -8.16 -0.41 7.29e-15 Developmental language disorder (linguistic errors); CRC cis rs10504229 0.683 rs79284841 chr8:58107611 T/A cg08219700 chr8:58056026 NA 0.6 6.83 0.35 4.16e-11 Developmental language disorder (linguistic errors); CRC cis rs4319547 0.915 rs1473553 chr12:122985057 G/T cg05707623 chr12:122985044 ZCCHC8 -0.78 -9.85 -0.48 3.07e-20 Body mass index; CRC trans rs79976124 0.797 rs77895756 chr6:66626782 C/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.77 9.62 0.47 1.8e-19 Type 2 diabetes; CRC cis rs1065656 0.581 rs1065666 chr16:1839134 T/C cg09830162 chr16:1889614 FAHD1;C16orf73 0.57 6.97 0.36 1.79e-11 Insulin-like growth factors; CRC cis rs902774 0.818 rs73110471 chr12:53316821 G/A cg14581129 chr12:53358946 NA -0.51 -5.7 -0.3 2.62e-8 Prostate cancer; CRC trans rs596169 0.764 rs715685 chr1:219127037 G/C cg09853702 chr12:47665230 NA 0.77 6.43 0.33 4.58e-10 Intraocular pressure; CRC cis rs4718428 0.672 rs36038499 chr7:66289615 A/G cg12165864 chr7:66369176 NA -0.41 -5.62 -0.3 4.07e-8 Corneal structure; CRC cis rs34779708 0.931 rs11010067 chr10:35295431 C/G cg03585969 chr10:35415529 CREM -0.57 -7.85 -0.4 5.91e-14 Inflammatory bowel disease;Crohn's disease; CRC cis rs12188164 0.714 rs11741954 chr5:421455 G/T cg16322479 chr5:444228 EXOC3;C5orf55 0.43 6.74 0.35 7.23e-11 Cystic fibrosis severity; CRC cis rs2836974 0.831 rs34592564 chr21:40516288 G/C cg06238570 chr21:40685208 BRWD1 0.72 9.45 0.46 6.57e-19 Cognitive function; CRC trans rs208520 0.690 rs12192851 chr6:66705862 G/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 1.04 14.83 0.63 1.82e-38 Exhaled nitric oxide output; CRC cis rs10979 0.965 rs9496679 chr6:143896741 G/T cg25407410 chr6:143891975 LOC285740 -0.84 -13.71 -0.6 3.9e-34 Hypospadias; CRC cis rs6938 0.618 rs12911254 chr15:75166335 G/A cg17294928 chr15:75287854 SCAMP5 0.53 8.26 0.41 3.69e-15 Breast cancer; CRC cis rs9467711 0.559 rs9348721 chr6:26485573 A/G cg12315302 chr6:26189340 HIST1H4D 0.73 5.8 0.3 1.6e-8 Autism spectrum disorder or schizophrenia; CRC cis rs1008375 0.932 rs4235390 chr4:17696378 G/T cg16339924 chr4:17578868 LAP3 0.49 6.6 0.34 1.68e-10 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs270601 0.721 rs270621 chr5:131605821 C/A cg27615366 chr5:131592974 PDLIM4 0.33 5.85 0.31 1.16e-8 Acylcarnitine levels; CRC cis rs10197940 0.662 rs72860233 chr2:152289767 G/A cg19508488 chr2:152266495 RIF1 0.59 8.33 0.42 2.14e-15 Lung cancer; CRC cis rs4853012 0.941 rs2421752 chr2:74341615 A/G cg01017244 chr2:74357527 NA 0.66 8.6 0.43 3.3e-16 Gestational age at birth (maternal effect); CRC trans rs3960554 0.741 rs28446604 chr7:75662518 C/T cg19862616 chr7:65841803 NCRNA00174 0.7 8.28 0.42 3.13e-15 Eotaxin levels; CRC cis rs896854 1.000 rs13255935 chr8:95965685 C/A cg23172400 chr8:95962367 TP53INP1 -0.47 -7.79 -0.39 8.57e-14 Type 2 diabetes; CRC cis rs6456156 0.792 rs4710179 chr6:167513692 G/T cg07741184 chr6:167504864 NA 0.49 8.47 0.42 8.25e-16 Primary biliary cholangitis; CRC cis rs4689388 0.853 rs13103357 chr4:6294544 A/G cg25554036 chr4:6271136 WFS1 0.53 8.7 0.43 1.59e-16 Type 2 diabetes and other traits;Type 2 diabetes; CRC cis rs7618915 0.501 rs3733039 chr3:52719088 C/T cg05573699 chr3:52720067 GNL3;PBRM1 -0.49 -7.29 -0.37 2.31e-12 Bipolar disorder; CRC cis rs7726839 0.540 rs72705030 chr5:645562 C/T cg09021430 chr5:549028 NA -0.72 -8.11 -0.41 9.84e-15 Obesity-related traits; CRC cis rs11252926 0.545 rs10466270 chr10:556129 A/G cg03684893 chr10:554711 DIP2C -0.47 -8.45 -0.42 9.64e-16 Psychosis in Alzheimer's disease; CRC cis rs629535 0.783 rs658407 chr8:70035247 T/C cg26132723 chr8:70041827 NA 0.35 5.72 0.3 2.41e-8 Dupuytren's disease; CRC cis rs6570726 0.764 rs451108 chr6:145844309 T/C cg13319975 chr6:146136371 FBXO30 -0.45 -6.78 -0.35 5.73e-11 Lobe attachment (rater-scored or self-reported); CRC cis rs736801 0.780 rs12521868 chr5:131784393 A/C cg14196790 chr5:131705035 SLC22A5 -0.37 -6.23 -0.32 1.41e-9 Breast cancer;Mosquito bite size; CRC cis rs6502050 0.835 rs7212441 chr17:80080047 T/G cg22110888 chr17:80059540 CCDC57 -0.41 -6.38 -0.33 6.13e-10 Life satisfaction; CRC cis rs7149337 0.805 rs7146561 chr14:51608889 C/G cg23942311 chr14:51606299 NA 0.83 17.53 0.69 4.82e-49 Cancer; CRC cis rs17401966 0.894 rs12141201 chr1:10454714 G/A cg19773385 chr1:10388646 KIF1B -0.68 -10.9 -0.51 8.21e-24 Hepatocellular carcinoma; CRC cis rs367615 0.552 rs2963024 chr5:108730773 C/T cg17395555 chr5:108820864 NA -0.33 -6.43 -0.33 4.51e-10 Colorectal cancer (SNP x SNP interaction); CRC cis rs10946940 0.965 rs4713112 chr6:27516833 G/T cg02683197 chr6:28174875 NA -0.54 -7.43 -0.38 9.17e-13 Systemic lupus erythematosus; CRC cis rs8077889 0.672 rs3785810 chr17:41850689 C/G cg25876840 chr17:41920477 NA 0.42 6.79 0.35 5.19e-11 Triglycerides; CRC cis rs13191362 0.507 rs2023015 chr6:163060528 A/T cg06582575 chr6:163149167 PACRG;PARK2 -0.55 -8.64 -0.43 2.49e-16 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs5769765 0.818 rs138850 chr22:50193337 C/T cg02269571 chr22:50332266 NA 0.46 6.39 0.33 5.77e-10 Schizophrenia; CRC cis rs950169 0.614 rs12911536 chr15:84673030 G/T cg17507749 chr15:85114479 UBE2QP1 0.66 9.0 0.44 1.79e-17 Schizophrenia; CRC cis rs7927771 0.832 rs11601173 chr11:47401058 A/G cg20307385 chr11:47447363 PSMC3 -0.62 -9.24 -0.45 3.24e-18 Subjective well-being; CRC cis rs9457247 0.561 rs916331 chr6:167470559 T/G cg07741184 chr6:167504864 NA 0.44 7.41 0.38 1.11e-12 Crohn's disease; CRC cis rs853679 0.517 rs9380056 chr6:28104476 C/T cg15786705 chr6:28176104 NA 0.77 9.75 0.47 6.92e-20 Depression; CRC cis rs736408 0.609 rs2336545 chr3:52787603 C/T cg15147215 chr3:52552868 STAB1 0.6 9.93 0.48 1.75e-20 Bipolar disorder; CRC cis rs3741404 0.609 rs641430 chr11:63869531 C/T cg05016508 chr11:63871570 FLRT1;MACROD1 -0.55 -9.21 -0.45 4.05e-18 Platelet count; CRC cis rs1448094 0.842 rs7966352 chr12:86438705 A/C cg18827107 chr12:86230957 RASSF9 -0.37 -5.85 -0.31 1.21e-8 Major depressive disorder; CRC cis rs425277 0.606 rs16824792 chr1:2039521 G/T cg12639453 chr1:2035780 PRKCZ -0.38 -7.44 -0.38 8.82e-13 Height; CRC cis rs2274273 0.870 rs8018110 chr14:55641714 C/T cg23234261 chr14:55582407 NA -0.3 -5.8 -0.3 1.59e-8 Protein biomarker; CRC cis rs12983728 0.505 rs12460050 chr19:58666109 G/A cg24884572 chr19:58661833 ZNF329 0.45 5.69 0.3 2.76e-8 Cholesterol, total; CRC cis rs17767392 0.958 rs35231795 chr14:71987374 T/G cg13720639 chr14:72061746 SIPA1L1 -0.57 -7.29 -0.37 2.29e-12 Mitral valve prolapse; CRC cis rs7786877 0.723 rs73407376 chr7:100215200 C/T cg16850897 chr7:100343110 ZAN -0.51 -6.27 -0.33 1.12e-9 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs875971 1.000 rs778722 chr7:65844828 T/C cg00343986 chr7:65444356 GUSB 0.43 6.3 0.33 9.66e-10 Aortic root size; CRC cis rs9308731 0.644 rs1837369 chr2:111874276 C/T cg04202892 chr2:111875749 ACOXL 0.4 6.44 0.33 4.2e-10 Chronic lymphocytic leukemia; CRC cis rs9916302 0.904 rs2338800 chr17:37498149 C/G cg03013999 chr17:37608204 MED1 -0.48 -7.44 -0.38 8.77e-13 Glomerular filtration rate (creatinine); CRC cis rs6694672 1.000 rs7554757 chr1:196973054 A/T cg13682187 chr1:196946512 CFHR5 0.53 7.26 0.37 2.86e-12 Asthma; CRC cis rs9487051 0.676 rs13210693 chr6:109598964 A/G cg12927641 chr6:109611667 NA 0.35 6.08 0.32 3.34e-9 Reticulocyte fraction of red cells; CRC cis rs801193 1.000 rs7789184 chr7:66210195 A/T cg00343986 chr7:65444356 GUSB 0.49 7.26 0.37 2.87e-12 Aortic root size; CRC cis rs11711311 0.822 rs9850256 chr3:113408382 T/C cg15478005 chr3:113465772 ATP6V1A;NAA50 0.41 5.72 0.3 2.37e-8 IgG glycosylation; CRC cis rs6540559 0.611 rs61747285 chr1:210004332 G/A cg22029157 chr1:209979665 IRF6 0.68 7.77 0.39 1.02e-13 Cleft lip with or without cleft palate; CRC cis rs514406 0.505 rs7543239 chr1:53162416 A/G cg08859206 chr1:53392774 SCP2 -0.39 -5.86 -0.31 1.12e-8 Monocyte count; CRC cis rs11098499 0.955 rs6815725 chr4:120158410 C/A cg24375607 chr4:120327624 NA 0.43 6.78 0.35 5.71e-11 Corneal astigmatism; CRC cis rs875971 0.830 rs778711 chr7:65851657 G/A cg00343986 chr7:65444356 GUSB 0.45 6.22 0.32 1.52e-9 Aortic root size; CRC trans rs10504229 0.861 rs116964504 chr8:58185354 A/C cg04077850 chr5:125800366 GRAMD3 0.37 6.27 0.33 1.15e-9 Developmental language disorder (linguistic errors); CRC cis rs798766 1.000 rs798741 chr4:1712413 A/G cg05874882 chr4:1763078 NA -0.35 -6.49 -0.34 3.07e-10 Bladder cancer;Urinary bladder cancer; CRC trans rs57221529 0.825 rs72703051 chr5:582997 G/A cg11887960 chr12:57824829 NA 0.63 6.43 0.33 4.4e-10 Lung disease severity in cystic fibrosis; CRC cis rs8180040 0.715 rs6772670 chr3:47191349 G/A cg02527881 chr3:46936655 PTH1R -0.4 -7.44 -0.38 8.8e-13 Colorectal cancer; CRC cis rs9814567 1.000 rs9289471 chr3:134230811 A/G cg06109529 chr3:134205091 CEP63;ANAPC13 -0.81 -12.24 -0.56 1.24e-28 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs1348850 0.914 rs8941 chr2:178406481 C/T cg22681709 chr2:178499509 PDE11A -0.38 -6.89 -0.36 2.88e-11 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs10193935 0.901 rs12615383 chr2:42610551 A/G cg27598129 chr2:42591480 NA 0.68 7.4 0.38 1.17e-12 Colonoscopy-negative controls vs population controls; CRC cis rs9916302 0.904 rs12452880 chr17:37591149 G/C cg15445000 chr17:37608096 MED1 0.42 9.26 0.45 2.62e-18 Glomerular filtration rate (creatinine); CRC cis rs951366 0.617 rs708727 chr1:205767885 G/A cg24739457 chr1:205821442 NA 0.44 6.42 0.33 4.82e-10 Menarche (age at onset); CRC cis rs2072499 0.838 rs2758619 chr1:156162559 A/G cg24450063 chr1:156163899 SLC25A44 1.15 27.61 0.84 1.1e-87 Testicular germ cell tumor; CRC cis rs2425143 1.000 rs6058325 chr20:34388806 G/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.49 -5.81 -0.3 1.51e-8 Blood protein levels; CRC cis rs7613875 0.600 rs2624848 chr3:50165101 T/C cg05623727 chr3:50126028 RBM5 -0.59 -10.0 -0.48 9.64e-21 Body mass index; CRC cis rs2115630 0.967 rs8027779 chr15:85255385 T/C cg09876464 chr15:85330779 ZNF592 0.46 7.57 0.39 3.84e-13 P wave terminal force; CRC cis rs2415984 0.579 rs2415999 chr14:46966224 T/C cg14871534 chr14:47121158 RPL10L -0.4 -6.01 -0.31 5.05e-9 Number of children ever born; CRC cis rs972578 0.535 rs3091364 chr22:43414330 A/G cg01576275 chr22:43409880 NA 0.38 5.85 0.31 1.21e-8 Mean platelet volume; CRC cis rs6089584 0.888 rs2386555 chr20:60612373 C/T cg12751644 chr20:60527061 NA -0.38 -5.98 -0.31 5.71e-9 Body mass index; CRC cis rs4566357 0.615 rs10178098 chr2:227914425 C/T cg11843606 chr2:227700838 RHBDD1 -0.45 -7.02 -0.36 1.28e-11 Coronary artery disease; CRC cis rs1552244 0.882 rs67762674 chr3:10014485 C/T cg13047869 chr3:10149882 C3orf24 0.53 7.09 0.36 8.22e-12 Alzheimer's disease; CRC cis rs9400271 0.632 rs9384704 chr6:109587209 C/T cg01475377 chr6:109611718 NA -0.35 -6.11 -0.32 2.87e-9 Sum neutrophil eosinophil counts;Sum basophil neutrophil counts;White blood cell count;Neutrophil count;Myeloid white cell count;Granulocyte count; CRC cis rs763014 1.000 rs7205409 chr16:642610 A/G cg07343612 chr16:622815 PIGQ -0.74 -12.35 -0.56 4.66e-29 Height; CRC cis rs9796 0.870 rs3101436 chr15:41287689 A/G cg18705301 chr15:41695430 NDUFAF1 0.34 5.75 0.3 2.09e-8 Menopause (age at onset); CRC cis rs7666738 0.830 rs3852123 chr4:98697586 A/G cg17366294 chr4:99064904 C4orf37 0.42 6.97 0.36 1.7e-11 Colonoscopy-negative controls vs population controls; CRC cis rs7584330 0.554 rs7587496 chr2:238387632 A/G cg14458575 chr2:238380390 NA 0.83 10.94 0.52 5.81e-24 Prostate cancer; CRC cis rs17401966 0.898 rs12117635 chr1:10317445 C/T cg19773385 chr1:10388646 KIF1B -0.65 -10.79 -0.51 1.95e-23 Hepatocellular carcinoma; CRC cis rs76878669 0.561 rs4930363 chr11:66169676 C/T cg18002602 chr11:66138449 SLC29A2 0.28 6.02 0.32 4.6e-9 Educational attainment (years of education); CRC cis rs3126085 0.515 rs10788835 chr1:152330945 T/C cg09127314 chr1:152161683 NA -0.43 -5.66 -0.3 3.38e-8 Atopic dermatitis; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg04652621 chr7:150671807 KCNH2 0.43 6.73 0.35 7.5e-11 Liver disease severity in Alagille syndrome; CRC cis rs7107174 0.579 rs10793299 chr11:78018954 T/A cg02023728 chr11:77925099 USP35 0.54 7.6 0.39 3.18e-13 Testicular germ cell tumor; CRC cis rs11031096 0.535 rs10767886 chr11:4218391 T/C cg18678763 chr11:4115507 RRM1 -0.35 -5.71 -0.3 2.55e-8 Mean corpuscular volume;Mean corpuscular hemoglobin; CRC cis rs863345 0.584 rs1117125 chr1:158509396 T/C cg12129480 chr1:158549410 OR10X1 -0.3 -6.25 -0.33 1.3e-9 Pneumococcal bacteremia; CRC cis rs11148252 0.904 rs3892337 chr13:53029485 C/G cg02158880 chr13:53174818 NA 0.48 7.18 0.37 4.61e-12 Lewy body disease; CRC cis rs7487075 0.820 rs10467213 chr12:46720263 T/A cg22049899 chr12:47219821 SLC38A4 0.34 6.18 0.32 1.91e-9 Itch intensity from mosquito bite; CRC cis rs736408 0.522 rs6445535 chr3:52771468 T/C cg18404041 chr3:52824283 ITIH1 -0.41 -8.4 -0.42 1.36e-15 Bipolar disorder; CRC cis rs6598163 0.517 rs10902453 chr12:132297091 G/T cg07389463 chr12:132296394 NA -0.41 -6.23 -0.32 1.42e-9 Migraine; CRC cis rs3820068 0.524 rs34094056 chr1:15824154 G/T cg27534772 chr1:16042836 PLEKHM2 0.41 6.9 0.36 2.69e-11 Systolic blood pressure; CRC cis rs4132509 0.948 rs1458023 chr1:243886673 A/G cg21452805 chr1:244014465 NA 0.5 6.84 0.35 3.85e-11 RR interval (heart rate); CRC cis rs7811142 1.000 rs11769700 chr7:100090049 T/C cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.6 7.74 0.39 1.27e-13 Platelet count; CRC cis rs2075371 0.933 rs1421482 chr7:133964383 A/G cg02659138 chr7:134003124 SLC35B4 0.35 6.12 0.32 2.7e-9 Mean platelet volume; CRC trans rs10982213 0.830 rs2274163 chr9:117188714 C/T cg12760041 chr2:211036890 C2orf67 -0.4 -5.96 -0.31 6.42e-9 Interleukin-6 levels; CRC cis rs7113874 0.569 rs2289921 chr11:8496611 G/C cg20771178 chr11:8615675 STK33 0.35 5.74 0.3 2.17e-8 Body mass index in physically active individuals;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs4478137 0.899 rs10857354 chr4:164239841 A/G cg06758707 chr4:164254230 NPY1R 0.39 6.01 0.31 4.89e-9 Subjective well-being (multi-trait analysis);Subjective well-being; CRC cis rs2836974 0.799 rs13047550 chr21:40515495 T/C cg07074390 chr21:40555500 PSMG1 -0.43 -5.68 -0.3 2.91e-8 Cognitive function; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg12074093 chr17:16256568 CENPV 0.42 6.81 0.35 4.53e-11 Liver disease severity in Alagille syndrome; CRC cis rs8060686 0.641 rs12600199 chr16:68069742 C/T cg08314208 chr16:67682810 RLTPR -0.61 -6.26 -0.33 1.2e-9 HDL cholesterol;Metabolic syndrome; CRC cis rs546131 0.928 rs558967 chr11:34827168 T/A cg11058730 chr11:34937778 PDHX;APIP 0.47 6.83 0.35 4e-11 Lung disease severity in cystic fibrosis; CRC cis rs2832191 0.692 rs2254872 chr21:30414724 C/T cg08807101 chr21:30365312 RNF160 0.72 11.63 0.54 1.95e-26 Dental caries; CRC cis rs9611565 0.802 rs73176692 chr22:41785735 G/A cg06481639 chr22:41940642 POLR3H -0.52 -6.04 -0.32 4.2e-9 Vitiligo; CRC cis rs870825 0.860 rs72703518 chr4:185602109 T/C cg04058563 chr4:185651563 MLF1IP 0.65 6.53 0.34 2.43e-10 Blood protein levels; CRC cis rs853679 0.517 rs3734573 chr6:28059437 T/C cg02683197 chr6:28174875 NA 0.82 10.03 0.48 7.9e-21 Depression; CRC cis rs6502050 0.835 rs6502065 chr17:80095642 T/C cg13198984 chr17:80129470 CCDC57 0.46 8.16 0.41 6.94e-15 Life satisfaction; CRC cis rs9309711 0.961 rs11890651 chr2:3482796 T/G cg10845886 chr2:3471009 TTC15 -0.67 -10.93 -0.52 6.5e-24 Neurofibrillary tangles; CRC trans rs11098499 0.580 rs12509234 chr4:120319434 T/C cg25214090 chr10:38739885 LOC399744 0.65 10.41 0.5 4.05e-22 Corneal astigmatism; CRC cis rs6921919 0.789 rs11970439 chr6:28303464 C/G cg21251018 chr6:28226885 NKAPL 0.41 5.92 0.31 8.14e-9 Autism spectrum disorder or schizophrenia; CRC cis rs2795502 0.882 rs2744087 chr10:43340270 A/C cg27426351 chr10:43362370 NA -0.6 -7.08 -0.36 8.62e-12 Blood protein levels; CRC cis rs4481887 0.741 rs6674078 chr1:248543026 G/A cg00666640 chr1:248458726 OR2T12 0.4 7.28 0.37 2.49e-12 Common traits (Other); CRC trans rs6550704 0.687 rs9865314 chr3:22634337 A/G cg23300289 chr9:132146083 NA -0.4 -6.07 -0.32 3.43e-9 Daytime sleep phenotypes; CRC trans rs561341 1.000 rs4795669 chr17:30244701 C/T cg27661571 chr11:113659931 NA -0.87 -10.28 -0.49 1.09e-21 Hip circumference adjusted for BMI; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg17839278 chr11:47664375 MTCH2 0.5 6.27 0.33 1.12e-9 Thyroid stimulating hormone; CRC cis rs2333194 0.844 rs17182286 chr14:73748908 C/T cg19682024 chr14:74008259 HEATR4;ACOT1 -0.4 -5.86 -0.31 1.13e-8 Bipolar disorder with mood-incongruent psychosis; CRC cis rs9487051 0.714 rs13209277 chr6:109624963 T/A cg01475377 chr6:109611718 NA -0.41 -7.39 -0.38 1.24e-12 Reticulocyte fraction of red cells; CRC cis rs4629710 0.592 rs11758994 chr6:131582022 A/C cg12606694 chr6:131520996 AKAP7 0.57 8.52 0.43 5.7e-16 Multiple myeloma (IgH translocation); CRC cis rs738322 0.967 rs132971 chr22:38561911 T/G cg17652424 chr22:38574118 PLA2G6 -0.22 -6.65 -0.34 1.25e-10 Cutaneous nevi; CRC cis rs7916697 0.947 rs4745950 chr10:69996455 A/G cg06988349 chr10:69991859 ATOH7 -0.34 -6.13 -0.32 2.49e-9 Optic disc area; CRC cis rs6121246 0.559 rs6060621 chr20:30261562 G/C cg13852791 chr20:30311386 BCL2L1 0.71 13.8 0.61 1.74e-34 Mean corpuscular hemoglobin; CRC cis rs7772486 0.754 rs4896838 chr6:146015451 T/C cg23711669 chr6:146136114 FBXO30 -0.75 -12.41 -0.56 2.84e-29 Lobe attachment (rater-scored or self-reported); CRC cis rs6993244 1 rs6993244 chr8:8863059 C/G cg06636001 chr8:8085503 FLJ10661 0.53 7.6 0.39 3.22e-13 Mean corpuscular hemoglobin; CRC cis rs4474465 0.790 rs10899541 chr11:78245573 A/G cg02023728 chr11:77925099 USP35 0.36 6.12 0.32 2.67e-9 Alzheimer's disease (survival time); CRC cis rs2197308 0.728 rs7304305 chr12:37932990 T/C cg26384229 chr12:38710491 ALG10B -0.64 -9.67 -0.47 1.28e-19 Morning vs. evening chronotype; CRC cis rs754466 0.580 rs10824576 chr10:79566040 G/C cg26805224 chr10:79626177 DLG5 -0.43 -6.33 -0.33 7.82e-10 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs875971 0.862 rs4718377 chr7:66049678 C/T cg00343986 chr7:65444356 GUSB -0.45 -6.22 -0.32 1.53e-9 Aortic root size; CRC cis rs8180040 0.729 rs11720439 chr3:47347003 T/G cg27129171 chr3:47204927 SETD2 -0.55 -8.0 -0.4 2.15e-14 Colorectal cancer; CRC cis rs6951245 1.000 rs79765398 chr7:1073764 A/G cg03188948 chr7:1209495 NA 0.64 6.55 0.34 2.25e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC trans rs703108 0.731 rs7898954 chr10:22323646 A/G cg15672675 chr1:40507006 CAP1 -0.52 -6.56 -0.34 2.08e-10 Monocyte percentage of white cells; CRC cis rs4268898 0.931 rs2111882 chr2:24434424 A/G cg06627628 chr2:24431161 ITSN2 0.59 8.9 0.44 3.73e-17 Asthma; CRC cis rs4588572 0.643 rs13359053 chr5:77690224 T/C cg11446398 chr5:77624930 NA -0.47 -6.55 -0.34 2.15e-10 Triglycerides; CRC trans rs10838798 0.607 rs11039537 chr11:48154603 A/G cg21153622 chr11:89784906 NA -0.44 -6.79 -0.35 5.17e-11 Height; CRC cis rs6912958 0.754 rs4587143 chr6:88292291 A/G cg12350822 chr6:88032061 C6orf162;GJB7 -0.35 -6.66 -0.34 1.13e-10 Monocyte percentage of white cells; CRC cis rs8028182 0.636 rs4886707 chr15:75755467 C/T cg20655648 chr15:75932815 IMP3 0.42 6.01 0.31 5.06e-9 Sudden cardiac arrest; CRC cis rs13315871 1.000 rs71311858 chr3:58323793 G/C cg20936604 chr3:58311152 NA -0.78 -7.38 -0.38 1.34e-12 Cholesterol, total; CRC cis rs9322193 0.961 rs4870144 chr6:149896676 C/G cg13206674 chr6:150067644 NUP43 0.63 9.28 0.46 2.36e-18 Lung cancer; CRC cis rs6951245 0.938 rs113642700 chr7:1105654 C/T cg26224354 chr7:1096374 C7orf50;GPR146 -0.95 -12.31 -0.56 6.7e-29 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs9309473 0.607 rs7604588 chr2:73571417 C/T cg20560298 chr2:73613845 ALMS1 -0.48 -6.63 -0.34 1.4e-10 Metabolite levels; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg11563264 chr4:190862026 FRG1 -0.45 -7.12 -0.37 6.94e-12 Myopia (pathological); CRC cis rs172166 0.611 rs203883 chr6:28078356 A/G cg23161317 chr6:28129485 ZNF389 0.47 6.62 0.34 1.48e-10 Cardiac Troponin-T levels; CRC cis rs9894429 1.000 rs7223613 chr17:79574803 C/T cg21028142 chr17:79581711 NPLOC4 -0.39 -8.62 -0.43 2.89e-16 Eye color traits; CRC cis rs875971 0.545 rs73142245 chr7:65691649 A/G cg18876405 chr7:65276391 NA 0.47 6.49 0.34 3.08e-10 Aortic root size; CRC cis rs4713118 0.621 rs4713132 chr6:28034035 A/G cg15786705 chr6:28176104 NA 0.72 9.36 0.46 1.33e-18 Parkinson's disease; CRC trans rs7615952 0.546 rs112919177 chr3:125346070 G/A cg00769240 chr8:12517080 NA -0.65 -7.34 -0.38 1.67e-12 Blood pressure (smoking interaction); CRC trans rs1455244 0.700 rs7229302 chr18:11508904 G/T cg11820993 chr17:79633565 CCDC137;C17orf90 0.39 5.98 0.31 5.86e-9 Schizophrenia; CRC trans rs2303319 0.504 rs62187655 chr2:162487440 C/G cg04269497 chr6:167369491 RNASET2 -0.74 -6.05 -0.32 3.85e-9 Cognitive function; CRC cis rs7586673 1.000 rs16845584 chr2:161923830 C/T cg16506815 chr2:162101123 NA -0.38 -5.63 -0.3 3.85e-8 Intelligence (multi-trait analysis); CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg05661282 chr19:58220370 ZNF154 0.24 6.5 0.34 2.9e-10 Diisocyanate-induced asthma; CRC cis rs2769264 0.602 rs11204777 chr1:151072049 G/A cg03258749 chr1:151040405 MLLT11 -0.56 -7.81 -0.4 7.54e-14 Blood trace element (Cu levels); CRC cis rs853679 0.517 rs16893666 chr6:28054707 C/T cg06470822 chr6:28175283 NA -1.01 -13.68 -0.6 4.92e-34 Depression; CRC cis rs7937682 0.924 rs1784782 chr11:111525764 A/C cg09085632 chr11:111637200 PPP2R1B -0.99 -19.28 -0.73 5.84e-56 Primary sclerosing cholangitis; CRC cis rs11758351 0.518 rs78871852 chr6:26221566 A/T cg22723502 chr6:26240528 HIST1H4F -0.35 -5.82 -0.31 1.4e-8 Gout;Renal underexcretion gout; CRC trans rs6703335 0.870 rs10803142 chr1:243598234 A/G cg00306905 chr10:121356070 TIAL1 0.43 6.03 0.32 4.32e-9 Schizophrenia;Schizophrenia, schizoaffective disorder or bipolar disorder; CRC cis rs6585424 1.000 rs11201972 chr10:81932680 C/T cg11900509 chr10:81946545 ANXA11 -0.72 -8.84 -0.44 5.72e-17 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs7591163 1.000 rs4300818 chr2:228713255 G/T cg20647610 chr2:228736258 WDR69 -0.5 -6.76 -0.35 6.37e-11 Blood pressure; CRC cis rs514406 0.825 rs1242328 chr1:53396869 A/G cg25767906 chr1:53392781 SCP2 -0.5 -8.04 -0.41 1.62e-14 Monocyte count; CRC cis rs11077998 0.903 rs8064554 chr17:80501093 A/G cg10255544 chr17:80519551 FOXK2 0.38 5.94 0.31 7.06e-9 Reticulocyte fraction of red cells; CRC cis rs4363385 0.720 rs1338178 chr1:152981550 A/G cg25856811 chr1:152973957 SPRR3 -0.25 -6.95 -0.36 1.97e-11 Inflammatory skin disease; CRC cis rs2380220 0.541 rs72928273 chr6:96079360 C/T cg07718321 chr6:96025334 MANEA -0.58 -7.22 -0.37 3.52e-12 Behavioural disinhibition (generation interaction); CRC cis rs12024301 0.557 rs79082707 chr1:183620572 C/G cg11505048 chr1:183622726 RGL1;APOBEC4 0.81 7.14 0.37 5.93e-12 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs8114671 0.562 rs1013677 chr20:33468793 C/T cg07148914 chr20:33460835 GGT7 0.36 6.18 0.32 1.9e-9 Height; CRC cis rs4423214 0.610 rs12793607 chr11:71129316 C/T cg05163923 chr11:71159392 DHCR7 -0.47 -6.68 -0.35 9.93e-11 Vitamin D levels; CRC cis rs9487051 0.837 rs2356817 chr6:109642675 G/A cg21918786 chr6:109611834 NA -0.42 -7.44 -0.38 8.63e-13 Reticulocyte fraction of red cells; CRC cis rs1322512 1.000 rs2250006 chr6:153006401 T/A cg03415253 chr6:152958462 SYNE1 0.4 6.04 0.32 4.18e-9 Tonometry; CRC cis rs8072100 0.744 rs34537623 chr17:45530203 A/G cg25173405 chr17:45401733 C17orf57 -0.48 -7.61 -0.39 2.97e-13 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs9916302 0.904 rs9904334 chr17:37468336 G/A cg07936489 chr17:37558343 FBXL20 0.82 12.72 0.57 2.08e-30 Glomerular filtration rate (creatinine); CRC cis rs2976388 0.590 rs3758082 chr8:143824483 A/G cg12516270 chr8:143859308 LYNX1 -0.39 -6.44 -0.33 4.17e-10 Urinary tract infection frequency; CRC cis rs13191362 0.935 rs34347104 chr6:163055716 C/T cg21926612 chr6:163149169 PACRG;PARK2 0.98 12.51 0.57 1.22e-29 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg13300549 chr12:10365696 GABARAPL1 0.4 6.38 0.33 6.15e-10 Liver disease severity in Alagille syndrome; CRC cis rs9443645 0.838 rs946022 chr6:79672133 G/T cg05283184 chr6:79620031 NA -0.58 -9.13 -0.45 7.2e-18 Intelligence (multi-trait analysis); CRC trans rs208520 1.000 rs12195505 chr6:66986279 T/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.88 10.79 0.51 1.94e-23 Exhaled nitric oxide output; CRC cis rs2243480 1.000 rs781157 chr7:65478311 G/A cg18252515 chr7:66147081 NA -1.06 -12.35 -0.56 4.92e-29 Diabetic kidney disease; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg25355076 chr5:39074677 RICTOR 0.41 5.99 0.31 5.39e-9 Anxiety disorder; CRC cis rs2439831 0.702 rs9989313 chr15:44152817 C/T cg02155558 chr15:43621948 ADAL;LCMT2 0.7 7.49 0.38 6.24e-13 Lung cancer in ever smokers; CRC cis rs73206853 0.620 rs112599609 chr12:111147643 C/T cg12870014 chr12:110450643 ANKRD13A 0.67 6.48 0.34 3.4e-10 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC cis rs853679 1.000 rs7740487 chr6:28216486 C/G cg03623178 chr6:28175578 NA 0.73 6.88 0.35 3.12e-11 Depression; CRC cis rs6541297 1.000 rs6686680 chr1:230280522 T/C cg20703242 chr1:230279135 GALNT2 0.52 7.7 0.39 1.58e-13 Coronary artery disease; CRC cis rs3087591 0.960 rs2905793 chr17:29470072 C/T cg24425628 chr17:29625626 OMG;NF1 0.85 16.13 0.66 1.59e-43 Hip circumference; CRC cis rs6479527 0.875 rs9299414 chr9:96805568 C/T cg14459158 chr9:96720562 NA 0.38 6.71 0.35 8.37e-11 Esophageal adenocarcinoma; CRC cis rs9322193 0.962 rs2342861 chr6:150098697 C/T cg13206674 chr6:150067644 NUP43 0.57 8.14 0.41 8.29e-15 Lung cancer; CRC cis rs832540 0.898 rs331497 chr5:56251660 G/T cg12311346 chr5:56204834 C5orf35 0.46 7.25 0.37 2.91e-12 Coronary artery disease; CRC trans rs1814175 0.791 rs11040472 chr11:49703116 C/T cg15704280 chr7:45808275 SEPT13 -1.01 -20.49 -0.75 9.84e-61 Height; CRC cis rs12477438 0.798 rs13414153 chr2:99624748 G/T cg14399236 chr2:99771627 LIPT1;TSGA10 -0.6 -8.31 -0.42 2.57e-15 Chronic sinus infection; CRC cis rs7666738 0.645 rs10013290 chr4:99082799 G/A cg17366294 chr4:99064904 C4orf37 0.35 5.77 0.3 1.82e-8 Colonoscopy-negative controls vs population controls; CRC cis rs6951245 0.872 rs75280240 chr7:1058511 C/T cg07217954 chr7:1067459 C7orf50 0.56 5.85 0.31 1.21e-8 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs6495122 0.501 rs6495151 chr15:75385990 A/G cg18612461 chr15:75251733 NA -0.39 -6.1 -0.32 2.9e-9 Caffeine consumption;Diastolic blood pressure;Coffee consumption; CRC cis rs4973397 0.810 rs12999051 chr2:232276992 T/A cg13347044 chr2:232276743 NA 0.52 7.49 0.38 6.2e-13 Anti-saccade response; CRC cis rs9611565 0.694 rs5758368 chr22:41862288 C/T cg06634786 chr22:41940651 POLR3H -0.62 -7.5 -0.38 5.96e-13 Vitiligo; CRC cis rs9914988 1.000 rs901975 chr17:27189774 A/G cg16670446 chr17:27188758 MIR451;MIR144 -0.6 -10.42 -0.5 3.64e-22 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs9611519 0.780 rs2284079 chr22:41658632 C/T cg03806693 chr22:41940476 POLR3H -0.66 -9.09 -0.45 9.31e-18 Neuroticism; CRC cis rs875971 0.660 rs13224319 chr7:66007363 A/G cg00343986 chr7:65444356 GUSB 0.5 7.44 0.38 8.9e-13 Aortic root size; CRC trans rs2303319 0.504 rs62189042 chr2:162602320 G/T cg25193742 chr10:104614220 C10orf32 -0.77 -6.51 -0.34 2.87e-10 Cognitive function; CRC cis rs7312933 0.558 rs1796382 chr12:42840955 C/G cg11827402 chr12:42719852 PPHLN1;ZCRB1 -0.64 -9.54 -0.47 3.45e-19 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CRC cis rs3126085 0.935 rs2291770 chr1:152179792 G/C cg09127314 chr1:152161683 NA 0.53 6.69 0.35 9.52e-11 Atopic dermatitis; CRC cis rs10256972 0.552 rs2949192 chr7:1203841 C/T cg04025307 chr7:1156635 C7orf50 0.64 10.23 0.49 1.66e-21 Longevity;Endometriosis; CRC cis rs10751667 0.621 rs11246375 chr11:999620 T/C ch.11.42038R chr11:967971 AP2A2 0.55 8.51 0.42 6.2e-16 Alzheimer's disease (late onset); CRC cis rs7208859 0.623 rs7212991 chr17:29143749 T/C cg13385521 chr17:29058706 SUZ12P 0.74 8.44 0.42 9.97e-16 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs2282802 0.651 rs10060071 chr5:139599097 T/C cg26211634 chr5:139558579 C5orf32 0.44 7.69 0.39 1.74e-13 Intelligence (multi-trait analysis); CRC cis rs3804749 0.934 rs13314114 chr3:122836000 T/C cg26084141 chr3:122786895 PDIA5 0.24 6.68 0.35 1.05e-10 Plateletcrit;Mean platelet volume;Platelet count;Platelet distribution width; CRC trans rs4955793 0.585 rs61796578 chr3:178615072 G/A cg11644478 chr21:40555479 PSMG1 0.65 6.06 0.32 3.83e-9 Post-traumatic stress disorder (asjusted for relatedness); CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg01021423 chr3:48541507 SHISA5 -0.43 -6.59 -0.34 1.79e-10 Myopia (pathological); CRC cis rs4332037 0.552 rs11773627 chr7:2002733 A/G cg23378565 chr7:2036160 MAD1L1 -0.45 -6.79 -0.35 5.26e-11 Bipolar disorder; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg03859306 chr9:131452634 SET 0.42 6.04 0.32 4.07e-9 Response to antipsychotic treatment; CRC cis rs709400 1.000 rs2403205 chr14:104143385 C/T cg24130564 chr14:104152367 KLC1 -0.43 -6.42 -0.33 4.68e-10 Body mass index; CRC cis rs17270561 0.609 rs9348692 chr6:25720812 A/G cg16482183 chr6:26056742 HIST1H1C 0.75 9.48 0.46 5.09e-19 Iron status biomarkers; CRC cis rs614226 0.516 rs1794748 chr12:120953758 A/G cg27489772 chr12:121021490 NA 0.49 6.91 0.36 2.53e-11 Type 1 diabetes nephropathy; CRC cis rs365302 1.000 rs371023 chr6:159618397 C/T cg14500486 chr6:159655392 FNDC1 0.53 7.76 0.39 1.05e-13 Coronary heart disease; CRC cis rs3751196 0.808 rs80023709 chr12:104213192 A/G cg02344784 chr12:104178138 NT5DC3 0.71 7.54 0.38 4.58e-13 Sense of smell; CRC cis rs2019137 0.905 rs2276561 chr2:113956371 G/C cg19083407 chr2:113993142 PAX8;LOC440839;LOC654433 -0.46 -6.44 -0.33 4.21e-10 Lymphocyte counts; CRC cis rs394563 0.775 rs420430 chr6:149785539 T/G cg11245181 chr6:149772854 ZC3H12D -0.59 -9.85 -0.48 3.17e-20 Dupuytren's disease; CRC trans rs11039798 0.502 rs961863 chr11:48417021 T/C cg15704280 chr7:45808275 SEPT13 -0.66 -6.94 -0.36 2.15e-11 Axial length; CRC cis rs1862618 0.853 rs10051747 chr5:56083289 C/A cg22800045 chr5:56110881 MAP3K1 0.56 6.12 0.32 2.64e-9 Initial pursuit acceleration; CRC cis rs9467711 0.659 rs13195509 chr6:26463660 C/T cg16898833 chr6:26189333 HIST1H4D 1.12 8.21 0.41 5.22e-15 Autism spectrum disorder or schizophrenia; CRC cis rs12541635 1.000 rs2881037 chr8:107090901 C/T cg10147462 chr8:107024639 NA -0.37 -6.2 -0.32 1.69e-9 Age of smoking initiation; CRC trans rs8035957 1.000 rs4924273 chr15:38846738 C/G cg16703956 chr5:1446217 SLC6A3 -0.28 -6.2 -0.32 1.7e-9 Type 1 diabetes; CRC cis rs7618501 0.602 rs2071207 chr3:50159844 T/C cg24308560 chr3:49941425 MST1R 0.5 8.31 0.42 2.46e-15 Intelligence (multi-trait analysis); CRC cis rs911119 0.955 rs7270413 chr20:23593821 C/G cg16589663 chr20:23618590 CST3 0.42 5.73 0.3 2.3e-8 Chronic kidney disease; CRC cis rs78456975 1.000 rs13413356 chr2:1553849 G/T cg26248373 chr2:1572462 NA -0.65 -7.15 -0.37 5.76e-12 Placebo response in major depressive disorder (% change in symptom score); CRC cis rs9325144 0.560 rs6582539 chr12:38630097 C/T cg26384229 chr12:38710491 ALG10B -0.56 -8.25 -0.41 3.91e-15 Morning vs. evening chronotype; CRC cis rs6694672 1.000 rs7516700 chr1:197110331 T/G cg13682187 chr1:196946512 CFHR5 0.46 7.37 0.38 1.38e-12 Asthma; CRC cis rs904251 0.600 rs11756241 chr6:37445101 C/T cg01843034 chr6:37503916 NA -0.38 -6.8 -0.35 4.85e-11 Cognitive performance; CRC cis rs2742417 0.967 rs2742439 chr3:45744248 G/A cg04837898 chr3:45731254 SACM1L -0.36 -5.92 -0.31 7.98e-9 Response to anti-depressant treatment in major depressive disorder; CRC cis rs3820928 0.845 rs1917126 chr2:227840923 G/T cg11843606 chr2:227700838 RHBDD1 -0.39 -5.64 -0.3 3.71e-8 Pulmonary function; CRC cis rs10256972 0.516 rs12702081 chr7:1141528 T/C cg07092213 chr7:1199455 ZFAND2A -0.42 -5.96 -0.31 6.58e-9 Longevity;Endometriosis; CRC cis rs6502050 0.814 rs62079997 chr17:80076888 C/T cg13198984 chr17:80129470 CCDC57 -0.48 -8.57 -0.43 3.99e-16 Life satisfaction; CRC cis rs7246967 0.673 rs12985825 chr19:22953451 A/C cg08271804 chr19:22816896 ZNF492 0.38 5.85 0.31 1.2e-8 Bronchopulmonary dysplasia; CRC cis rs853679 0.550 rs6901017 chr6:28152583 T/C cg03623178 chr6:28175578 NA 0.96 13.39 0.59 6.04e-33 Depression; CRC cis rs6815814 1.000 rs11722836 chr4:38811529 T/A cg06935464 chr4:38784597 TLR10 0.55 5.74 0.3 2.12e-8 Breast cancer; CRC cis rs8058578 1.000 rs7187359 chr16:30703155 G/A cg00531865 chr16:30841666 NA -0.45 -6.13 -0.32 2.58e-9 Multiple myeloma; CRC cis rs31872 1.000 rs31872 chr5:140372222 A/G cg19650706 chr5:140594406 PCDHB13 -0.46 -6.85 -0.35 3.73e-11 Visceral adipose tissue adjusted for BMI; CRC cis rs1552244 0.572 rs67439440 chr3:10169503 C/T cg13047869 chr3:10149882 C3orf24 0.53 6.49 0.34 3.25e-10 Alzheimer's disease; CRC cis rs6964587 1.000 rs2282975 chr7:91761638 A/G cg17063962 chr7:91808500 NA 0.82 14.46 0.62 5.12e-37 Breast cancer; CRC cis rs9517320 0.515 rs1107379 chr13:99198921 C/T cg07423050 chr13:99094983 FARP1 -0.53 -7.45 -0.38 8.23e-13 Longevity; CRC cis rs597539 0.615 rs629426 chr11:68671104 A/G cg06028808 chr11:68637592 NA 0.42 6.71 0.35 8.44e-11 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs4481887 0.760 rs4559544 chr1:248412507 T/G cg00666640 chr1:248458726 OR2T12 0.49 8.32 0.42 2.42e-15 Common traits (Other); CRC cis rs2252790 0.859 rs2157321 chr6:116683788 C/T cg18764771 chr6:116381957 FRK -0.23 -6.14 -0.32 2.4e-9 Fast beta electroencephalogram; CRC cis rs4969178 0.965 rs12451715 chr17:76397334 A/C cg05887092 chr17:76393375 PGS1 0.55 10.0 0.48 1.01e-20 HDL cholesterol levels; CRC cis rs4819052 0.851 rs4819046 chr21:46664955 C/T cg19498844 chr21:46707878 POFUT2;LOC642852 0.76 10.94 0.52 5.64e-24 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs5821446 1 rs5821446 chr17:65962538 A/AT cg12091567 chr17:66097778 LOC651250 0.6 7.69 0.39 1.69e-13 Eosinophil percentage of granulocytes; CRC cis rs3540 0.960 rs2238327 chr15:91012949 G/A cg04176472 chr15:90893244 GABARAPL3 0.34 5.84 0.31 1.28e-8 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; CRC cis rs2243480 1.000 rs35432774 chr7:65393019 G/C cg12463550 chr7:65579703 CRCP 0.64 6.15 0.32 2.27e-9 Diabetic kidney disease; CRC trans rs7615952 0.546 rs11718647 chr3:125352022 G/A cg02560186 chr11:3602584 NA -0.56 -7.23 -0.37 3.41e-12 Blood pressure (smoking interaction); CRC cis rs3767633 0.925 rs4656339 chr1:161915387 A/T cg09175582 chr1:161736000 ATF6 0.65 5.99 0.31 5.64e-9 IgG glycosylation; CRC cis rs1129187 0.755 rs9471985 chr6:42941324 T/C cg10862848 chr6:42927986 GNMT -0.38 -9.13 -0.45 6.96e-18 Alzheimer's disease in APOE e4+ carriers; CRC cis rs17270561 0.636 rs4360128 chr6:25734558 A/G cg17691542 chr6:26056736 HIST1H1C 0.73 9.26 0.45 2.71e-18 Iron status biomarkers; CRC cis rs2976388 0.609 rs2717550 chr8:143787808 T/A cg20041105 chr8:143859282 LYNX1 0.46 8.27 0.41 3.45e-15 Urinary tract infection frequency; CRC cis rs17376456 0.825 rs17372615 chr5:93124768 C/T cg25358565 chr5:93447407 FAM172A 1.0 9.49 0.46 4.89e-19 Diabetic retinopathy; CRC cis rs9303401 0.614 rs68100606 chr17:56500898 G/A cg02118635 chr17:56770003 RAD51C;TEX14 0.75 9.3 0.46 2.09e-18 Cognitive test performance; CRC cis rs7680126 0.596 rs10939723 chr4:10139105 G/T cg00071950 chr4:10020882 SLC2A9 -0.41 -5.77 -0.3 1.79e-8 Urate levels in lean individuals;Urate levels in overweight individuals;Urate levels in obese individuals; CRC cis rs6500395 1.000 rs4493038 chr16:48683920 A/G cg04672837 chr16:48644449 N4BP1 0.45 6.63 0.34 1.38e-10 Response to tocilizumab in rheumatoid arthritis; CRC cis rs7481584 0.624 rs421196 chr11:3048582 T/G cg25174290 chr11:3078921 CARS -0.41 -5.72 -0.3 2.44e-8 Calcium levels; CRC cis rs78456975 0.607 rs72776258 chr2:1530732 C/G cg12573674 chr2:1569213 NA -0.73 -7.37 -0.38 1.42e-12 Placebo response in major depressive disorder (% change in symptom score); CRC cis rs2415984 0.600 rs61993299 chr14:46944880 A/C cg14871534 chr14:47121158 RPL10L -0.44 -6.2 -0.32 1.66e-9 Number of children ever born; CRC cis rs6582630 0.572 rs1969363 chr12:38514872 A/G cg13010199 chr12:38710504 ALG10B 0.42 6.16 0.32 2.13e-9 Drug-induced liver injury (flucloxacillin); CRC cis rs7927771 1.000 rs12419692 chr11:47624714 A/C cg20307385 chr11:47447363 PSMC3 0.54 7.62 0.39 2.66e-13 Subjective well-being; CRC cis rs1552244 1.000 rs112509186 chr3:10156533 A/G cg10729496 chr3:10149963 C3orf24 0.54 6.97 0.36 1.71e-11 Alzheimer's disease; CRC cis rs4731207 0.698 rs10085793 chr7:124484166 T/C cg23710748 chr7:124431027 NA 0.38 6.08 0.32 3.42e-9 Cutaneous malignant melanoma; CRC cis rs801193 1.000 rs1553610 chr7:66197233 T/C cg05627663 chr7:65219948 SNORA22;CCT6P1 0.42 6.12 0.32 2.6e-9 Aortic root size; CRC cis rs73206853 0.841 rs73206870 chr12:110819953 T/C cg12870014 chr12:110450643 ANKRD13A 0.84 8.74 0.43 1.24e-16 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC cis rs11122272 0.735 rs2790873 chr1:231539685 A/G cg06096015 chr1:231504339 EGLN1 0.39 5.84 0.31 1.28e-8 Hemoglobin concentration; CRC cis rs12745968 0.653 rs7418336 chr1:93163385 A/G cg17283838 chr1:93427260 FAM69A -0.45 -6.09 -0.32 3.16e-9 Bipolar disorder and schizophrenia; CRC cis rs7017697 1.000 rs6980875 chr8:19685948 C/T cg03894339 chr8:19674705 INTS10 -0.42 -5.77 -0.3 1.85e-8 Breast cancer; CRC cis rs6952808 0.929 rs2280546 chr7:1976863 G/A cg04267008 chr7:1944627 MAD1L1 -0.76 -10.46 -0.5 2.69e-22 Bipolar disorder and schizophrenia; CRC cis rs1129187 0.902 rs10948059 chr6:42928461 C/T cg21280719 chr6:42927975 GNMT -0.44 -9.95 -0.48 1.48e-20 Alzheimer's disease in APOE e4+ carriers; CRC trans rs208520 0.526 rs9351542 chr6:66788571 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.16 -25.23 -0.81 6.72e-79 Exhaled nitric oxide output; CRC cis rs892961 0.932 rs55661113 chr17:75408386 A/C cg05865280 chr17:75406074 SEPT9 0.6 13.21 0.59 2.89e-32 Airflow obstruction; CRC cis rs7072216 0.763 rs733345 chr10:100164215 G/T cg26618903 chr10:100175079 PYROXD2 -0.52 -8.73 -0.43 1.28e-16 Metabolite levels; CRC cis rs8053891 0.615 rs34042070 chr16:72101525 C/G cg01557791 chr16:72042693 DHODH -0.55 -5.64 -0.3 3.6e-8 Coronary artery disease; CRC cis rs4713118 0.662 rs4713120 chr6:27721835 C/A cg15845792 chr6:28175446 NA 0.5 7.04 0.36 1.09e-11 Parkinson's disease; CRC cis rs6570726 0.738 rs6917199 chr6:145918320 G/A cg05347473 chr6:146136440 FBXO30 0.4 5.98 0.31 5.84e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs7726839 0.574 rs11739866 chr5:636299 C/T cg16447950 chr5:562315 NA -0.74 -9.76 -0.47 6.14e-20 Obesity-related traits; CRC cis rs4423214 1.000 rs4944956 chr11:71167765 C/T cg05163923 chr11:71159392 DHCR7 0.68 9.61 0.47 2e-19 Vitamin D levels; CRC cis rs727505 0.607 rs59635547 chr7:124796371 A/C cg23710748 chr7:124431027 NA -0.64 -10.25 -0.49 1.43e-21 Lewy body disease; CRC cis rs6831352 0.918 rs35662508 chr4:100050974 C/G cg13256891 chr4:100009986 ADH5 -0.66 -8.89 -0.44 4.04e-17 Alcohol dependence; CRC cis rs10256972 0.567 rs2949185 chr7:1209013 A/G cg26608667 chr7:1196370 ZFAND2A 0.46 7.38 0.38 1.29e-12 Longevity;Endometriosis; CRC cis rs2302190 0.882 rs12942018 chr17:56613277 C/T cg25885038 chr17:56607967 SEPT4 -0.52 -7.88 -0.4 4.84e-14 Vitamin D levels; CRC cis rs62244186 0.659 rs1806579 chr3:44509281 T/C cg10263370 chr3:44754102 ZNF502 -0.36 -5.95 -0.31 6.83e-9 Depressive symptoms; CRC cis rs7917772 0.503 rs11191330 chr10:104306160 G/T cg11453585 chr10:104263688 ACTR1A;SUFU 0.89 17.22 0.69 8.1e-48 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC cis rs921968 0.541 rs523305 chr2:219402691 T/C cg02176678 chr2:219576539 TTLL4 0.54 8.69 0.43 1.78e-16 Mean corpuscular hemoglobin concentration; CRC cis rs995000 0.931 rs1168018 chr1:63001120 A/C cg19896129 chr1:63156450 NA -0.45 -6.98 -0.36 1.65e-11 Triglyceride levels; CRC cis rs9467711 0.651 rs13200797 chr6:26122957 G/A cg19084075 chr6:26124329 HIST1H2AC;HIST1H2BC 0.69 5.66 0.3 3.36e-8 Autism spectrum disorder or schizophrenia; CRC cis rs2811415 0.597 rs10934840 chr3:127746083 G/C cg13719885 chr3:127795394 NA -0.37 -5.64 -0.3 3.69e-8 Lung function (FEV1/FVC); CRC cis rs6952808 0.692 rs11773316 chr7:2027354 C/T cg04267008 chr7:1944627 MAD1L1 -0.74 -10.5 -0.5 2.01e-22 Bipolar disorder and schizophrenia; CRC cis rs6433857 0.505 rs16867320 chr2:181362312 A/G cg23363182 chr2:181467187 NA 0.54 7.73 0.39 1.35e-13 Body mass index; CRC trans rs61931739 0.517 rs2101396 chr12:34048927 T/A cg26384229 chr12:38710491 ALG10B 0.48 6.57 0.34 1.92e-10 Morning vs. evening chronotype; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg08229018 chr4:119274133 PRSS12 0.41 7.25 0.37 3.05e-12 Liver disease severity in Alagille syndrome; CRC cis rs8044995 0.501 rs73613999 chr16:68390099 C/A cg05110241 chr16:68378359 PRMT7 -0.72 -7.66 -0.39 2.15e-13 Schizophrenia; CRC cis rs7786877 0.508 rs11765509 chr7:100310990 T/G cg20848291 chr7:100343083 ZAN -0.66 -9.86 -0.48 2.96e-20 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs8053891 0.615 rs3794695 chr16:72097827 C/T cg23815491 chr16:72088622 HP 0.56 6.11 0.32 2.74e-9 Coronary artery disease; CRC cis rs4478858 0.735 rs6676682 chr1:31809816 C/T cg00250761 chr1:31883323 NA -0.44 -8.5 -0.42 6.71e-16 Alcohol dependence; CRC cis rs7626444 0.625 rs2686596 chr3:196475119 T/C cg12930392 chr3:196481615 PAK2 0.41 7.3 0.37 2.23e-12 Monocyte count; CRC cis rs9291683 0.632 rs13101785 chr4:10042915 T/A cg11266682 chr4:10021025 SLC2A9 0.53 11.09 0.52 1.76e-24 Bone mineral density; CRC cis rs9611565 0.694 rs9607816 chr22:41950897 G/A cg06634786 chr22:41940651 POLR3H -0.67 -7.97 -0.4 2.61e-14 Vitiligo; CRC cis rs769267 0.930 rs7256149 chr19:19566255 T/C cg01262667 chr19:19385393 TM6SF2 0.36 5.92 0.31 7.96e-9 Tonsillectomy; CRC cis rs11148252 0.774 rs9596649 chr13:52934610 A/G cg00495681 chr13:53174319 NA -0.64 -10.11 -0.49 4.21e-21 Lewy body disease; CRC cis rs2019137 0.560 rs7421852 chr2:113990261 G/A cg02675527 chr2:114030824 PAX8;LOC440839 -0.41 -6.0 -0.31 5.13e-9 Lymphocyte counts; CRC cis rs3087591 0.960 rs2066736 chr17:29559932 C/A cg24425628 chr17:29625626 OMG;NF1 -0.82 -15.23 -0.64 5.11e-40 Hip circumference; CRC cis rs713587 0.563 rs2033655 chr2:25101092 C/T cg22495460 chr2:25135724 ADCY3 -0.87 -16.43 -0.67 1.04e-44 Body mass index in non-asthmatics; CRC cis rs910316 1.000 rs876403 chr14:75602834 A/T cg08847533 chr14:75593920 NEK9 0.94 18.35 0.71 2.73e-52 Height; CRC cis rs35110281 0.805 rs2838319 chr21:44991901 A/G cg01579765 chr21:45077557 HSF2BP -0.37 -7.17 -0.37 5.07e-12 Mean corpuscular volume; CRC cis rs7927592 0.871 rs11228284 chr11:68322767 A/T cg01657329 chr11:68192670 LRP5 -0.46 -6.65 -0.34 1.22e-10 Total body bone mineral density; CRC cis rs7927592 0.513 rs689075 chr11:68194432 A/C cg01657329 chr11:68192670 LRP5 -0.61 -9.74 -0.47 7.11e-20 Total body bone mineral density; CRC cis rs10876993 0.890 rs774887 chr12:58034835 A/G cg18357645 chr12:58087776 OS9 0.5 6.78 0.35 5.7e-11 Celiac disease or Rheumatoid arthritis; CRC cis rs7666738 0.791 rs6853608 chr4:99047916 A/G cg05340658 chr4:99064831 C4orf37 0.6 9.35 0.46 1.4e-18 Colonoscopy-negative controls vs population controls; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg14534967 chr7:73153139 ABHD11 0.45 6.38 0.33 5.89e-10 Response to antipsychotic treatment; CRC cis rs2286885 1.000 rs10819171 chr9:129253074 G/A cg15282417 chr9:129245246 FAM125B 0.44 8.2 0.41 5.43e-15 Intraocular pressure; CRC trans rs944990 0.595 rs10123378 chr9:96375217 C/T cg10695429 chr3:185542769 IGF2BP2 0.42 6.12 0.32 2.69e-9 Body mass index; CRC cis rs6684514 1.000 rs11264462 chr1:156241728 G/A cg16558208 chr1:156270281 VHLL 0.61 9.64 0.47 1.58e-19 Mean corpuscular hemoglobin concentration;Glycated hemoglobin levels; CRC cis rs7255374 0.566 rs7255904 chr19:41529020 C/T cg27089200 chr19:41531976 NA 0.34 6.29 0.33 9.96e-10 DDT metabolite (p,p'-DDE levels); CRC cis rs2836974 0.583 rs2735307 chr21:40713358 C/T cg11644478 chr21:40555479 PSMG1 0.47 6.9 0.36 2.68e-11 Cognitive function; CRC cis rs35110281 0.667 rs4819291 chr21:45123139 G/A cg01579765 chr21:45077557 HSF2BP -0.32 -5.88 -0.31 9.96e-9 Mean corpuscular volume; CRC cis rs6976053 0.868 rs3087504 chr7:100486088 C/T cg10426581 chr7:100472382 SRRT 0.38 5.78 0.3 1.74e-8 Plasminogen activator inhibitor type 1 levels (PAI-1); CRC cis rs2797160 1.000 rs6904992 chr6:126016003 G/A cg05901451 chr6:126070800 HEY2 0.39 6.06 0.32 3.66e-9 Endometrial cancer; CRC cis rs3741404 0.609 rs669913 chr11:63869879 A/G cg19465662 chr11:63993652 NUDT22;TRPT1 0.6 9.34 0.46 1.5e-18 Platelet count; CRC cis rs9942416 0.660 rs61173369 chr5:74997995 A/G cg00601450 chr5:74908170 NA 0.39 5.61 0.3 4.34e-8 Age-related disease endophenotypes; CRC cis rs4076764 0.522 rs4265409 chr1:163414559 C/T cg24596788 chr1:163392923 NA -0.54 -8.45 -0.42 9.67e-16 Motion sickness; CRC cis rs6570726 0.599 rs9376951 chr6:145898911 C/T cg23711669 chr6:146136114 FBXO30 0.64 9.49 0.46 4.86e-19 Lobe attachment (rater-scored or self-reported); CRC cis rs4808199 0.895 rs4808194 chr19:19435680 T/G cg03709012 chr19:19516395 GATAD2A 0.99 11.61 0.54 2.39e-26 Nonalcoholic fatty liver disease; CRC cis rs68170813 0.559 rs78888729 chr7:106940957 G/C cg02696742 chr7:106810147 HBP1 -0.57 -6.32 -0.33 8.44e-10 Coronary artery disease; CRC cis rs1797081 0.967 rs780632 chr10:16861400 A/G cg23933602 chr10:16859644 RSU1 -1.08 -24.46 -0.8 5.03e-76 Platelet distribution width; CRC trans rs916888 0.687 rs199456 chr17:44797919 C/T cg10053473 chr17:62856997 LRRC37A3 -0.79 -8.66 -0.43 2.2e-16 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs73198271 0.531 rs17154756 chr8:8652394 C/T cg01851573 chr8:8652454 MFHAS1 0.55 6.84 0.35 3.76e-11 Bone ultrasound measurement (broadband ultrasound attenuation); CRC cis rs4654899 0.714 rs12401630 chr1:21495049 G/A cg02927042 chr1:21476669 EIF4G3 -0.5 -7.85 -0.4 5.72e-14 Superior frontal gyrus grey matter volume; CRC cis rs8177253 1.000 rs3811647 chr3:133484029 G/A cg16262614 chr3:133464971 TF 0.34 6.06 0.32 3.66e-9 Iron status biomarkers; CRC cis rs28386778 0.830 rs6504180 chr17:61813169 T/C cg23090583 chr17:61904693 PSMC5;FTSJ3 1.03 19.77 0.74 6.66e-58 Prudent dietary pattern; CRC cis rs10504229 1.000 rs61998258 chr8:58192284 T/C cg02725872 chr8:58115012 NA -0.38 -6.43 -0.33 4.44e-10 Developmental language disorder (linguistic errors); CRC cis rs13064411 0.627 rs9872168 chr3:113233132 A/C cg10517650 chr3:113235015 CCDC52 -0.41 -7.07 -0.36 9.15e-12 Response to simvastatin treatment (PCSK9 protein level change); CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg27447557 chr1:165796797 UCK2 0.44 6.37 0.33 6.5e-10 Anxiety disorder; CRC cis rs3741404 0.672 rs4980524 chr11:63959259 A/C cg06219103 chr11:63990595 FERMT3 -0.43 -6.78 -0.35 5.6e-11 Platelet count; CRC cis rs1348850 0.914 rs4893823 chr2:178285811 C/T cg02961200 chr2:178257176 LOC100130691;AGPS -0.6 -8.92 -0.44 3.27e-17 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs2013441 1.000 rs2703816 chr17:20118887 A/G cg13482628 chr17:19912719 NA -0.41 -6.46 -0.34 3.67e-10 Obesity-related traits; CRC cis rs250677 0.652 rs168751 chr5:148438264 C/T cg23229984 chr5:148520753 ABLIM3 0.51 6.68 0.35 1.01e-10 Breast cancer; CRC cis rs12586317 0.547 rs2273154 chr14:35433187 C/T cg16230307 chr14:35515116 FAM177A1 0.82 9.52 0.46 3.73e-19 Psoriasis; CRC trans rs7507204 0.530 rs4807470 chr19:3443470 A/T cg08382705 chr11:45687319 CHST1 -0.44 -8.08 -0.41 1.24e-14 Height; CRC cis rs7945705 0.902 rs2012696 chr11:8995818 A/C cg00186954 chr11:8933980 ST5;C11orf17 0.43 6.7 0.35 8.89e-11 Hemoglobin concentration; CRC cis rs116095464 0.558 rs3213838 chr5:223890 G/C cg22496380 chr5:211416 CCDC127 -0.84 -9.73 -0.47 7.72e-20 Breast cancer; CRC cis rs477895 0.653 rs11603212 chr11:63927810 C/T cg19465662 chr11:63993652 NUDT22;TRPT1 -0.72 -8.86 -0.44 5.29e-17 Mean platelet volume; CRC cis rs4555082 0.834 rs2735816 chr14:105721603 C/G cg06808227 chr14:105710500 BRF1 0.63 9.45 0.46 6.58e-19 Mean platelet volume;Platelet distribution width; CRC cis rs13256369 0.802 rs11249887 chr8:8562184 T/C cg00074818 chr8:8560427 CLDN23 0.4 7.1 0.36 7.63e-12 Obesity-related traits; CRC cis rs1878931 0.501 rs4785934 chr16:3419934 G/T cg26668626 chr16:3451006 ZNF174;ZNF434 0.7 9.64 0.47 1.61e-19 Body mass index (adult); CRC cis rs7746199 0.736 rs6904596 chr6:27491299 G/A cg12273811 chr6:28175739 NA 0.69 5.8 0.3 1.53e-8 Gait speed in old age;Autism spectrum disorder or schizophrenia; CRC cis rs1552244 0.572 rs3774208 chr3:10164722 T/G cg13047869 chr3:10149882 C3orf24 0.54 6.49 0.34 3.1e-10 Alzheimer's disease; CRC trans rs867371 0.519 rs1566560 chr15:82524457 C/T cg04831495 chr15:85060580 GOLGA6L5 -0.39 -6.08 -0.32 3.32e-9 Cognitive ability;Cognitive ability (multi-trait analysis); CRC cis rs9311676 0.609 rs1126551 chr3:58416535 C/T cg06643156 chr3:58380774 PXK 0.42 6.43 0.33 4.39e-10 Systemic lupus erythematosus; CRC cis rs6951245 1.000 rs78185558 chr7:1090183 G/C cg18402987 chr7:1209562 NA 0.59 6.44 0.33 4.31e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs780096 0.505 rs12475426 chr2:27599132 G/A cg21248554 chr2:27665150 KRTCAP3 -0.31 -7.18 -0.37 4.7e-12 Total body bone mineral density; CRC cis rs6952808 0.575 rs2056479 chr7:1954273 G/A cg14004847 chr7:1930337 MAD1L1 -0.4 -5.86 -0.31 1.11e-8 Bipolar disorder and schizophrenia; CRC cis rs860295 0.702 rs3851912 chr1:155586444 T/G cg02153340 chr1:155202674 NA -0.51 -6.43 -0.33 4.4e-10 Body mass index; CRC cis rs2797160 0.651 rs1268067 chr6:126036621 T/C cg05901451 chr6:126070800 HEY2 0.5 8.14 0.41 8e-15 Endometrial cancer; CRC cis rs916888 0.773 rs199447 chr17:44812188 C/T cg17911788 chr17:44343683 NA -0.65 -7.56 -0.38 4.17e-13 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs7772486 0.686 rs702305 chr6:145973840 A/G cg13319975 chr6:146136371 FBXO30 0.44 6.68 0.35 1.04e-10 Lobe attachment (rater-scored or self-reported); CRC cis rs7202877 0.706 rs40217 chr16:75480066 C/A cg03315344 chr16:75512273 CHST6 -0.53 -6.13 -0.32 2.55e-9 Type 2 diabetes;Type 1 diabetes; CRC cis rs6076065 0.723 rs6137905 chr20:23340938 G/A cg11657817 chr20:23433608 CST11 0.45 6.57 0.34 2e-10 Facial morphology (factor 15, philtrum width); CRC cis rs6461049 0.800 rs3800913 chr7:2163237 A/G cg21782813 chr7:2030301 MAD1L1 0.49 8.84 0.44 5.75e-17 Schizophrenia; CRC trans rs7395662 0.591 rs4882093 chr11:48530820 G/A cg21153622 chr11:89784906 NA -0.51 -8.52 -0.43 5.87e-16 HDL cholesterol; CRC cis rs1065656 0.589 rs391543 chr16:1915583 T/G cg09830162 chr16:1889614 FAHD1;C16orf73 0.56 8.15 0.41 7.75e-15 Insulin-like growth factors; CRC cis rs2354432 0.556 rs1932979 chr1:146708912 A/G cg25205988 chr1:146714368 CHD1L -1.11 -9.49 -0.46 4.7e-19 Mitochondrial DNA levels; CRC cis rs78707713 0.560 rs12784882 chr10:71230334 C/G cg12610070 chr10:71211762 TSPAN15 -0.43 -7.44 -0.38 8.89e-13 Venous thromboembolism; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg03426840 chr11:118661678 DDX6 0.48 7.66 0.39 2.07e-13 Liver disease severity in Alagille syndrome; CRC cis rs7731657 0.537 rs10076495 chr5:130362953 A/C cg08523029 chr5:130500466 HINT1 -0.47 -6.08 -0.32 3.32e-9 Fasting plasma glucose; CRC trans rs66887589 0.967 rs6844263 chr4:120433807 A/G cg25214090 chr10:38739885 LOC399744 0.41 6.34 0.33 7.8e-10 Diastolic blood pressure; CRC cis rs7949030 0.653 rs17773169 chr11:62318530 G/T cg22862634 chr11:62369728 EML3;MTA2 0.55 10.01 0.48 9.44e-21 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; CRC cis rs9467773 1.000 rs6940188 chr6:26562029 G/C cg09904177 chr6:26538194 HMGN4 0.85 14.73 0.63 4.51e-38 Intelligence (multi-trait analysis); CRC cis rs7945705 0.846 rs11042055 chr11:8756856 G/A cg21881798 chr11:8931708 C11orf17;ST5 0.47 6.69 0.35 9.43e-11 Hemoglobin concentration; CRC cis rs9783347 1.000 rs4150641 chr11:18370739 C/A cg15585147 chr11:18324498 HPS5 0.43 6.09 0.32 3.12e-9 Pancreatic cancer; CRC cis rs6570726 0.599 rs455001 chr6:145854450 A/T cg05347473 chr6:146136440 FBXO30 0.48 7.02 0.36 1.28e-11 Lobe attachment (rater-scored or self-reported); CRC cis rs7618915 0.547 rs3774365 chr3:52642487 T/C cg15147215 chr3:52552868 STAB1 -0.61 -10.15 -0.49 3.01e-21 Bipolar disorder; CRC cis rs4665809 1.000 rs12469163 chr2:26283587 T/C cg04944784 chr2:26401820 FAM59B -0.6 -7.63 -0.39 2.48e-13 Gut microbiome composition (summer); CRC cis rs2832191 0.716 rs2249028 chr21:30365322 G/A cg24692254 chr21:30365293 RNF160 0.85 16.06 0.66 2.81e-43 Dental caries; CRC cis rs6570726 0.875 rs373313 chr6:145857791 T/C cg23711669 chr6:146136114 FBXO30 0.7 12.51 0.57 1.19e-29 Lobe attachment (rater-scored or self-reported); CRC cis rs1862618 0.620 rs2591967 chr5:56233551 C/G cg03609598 chr5:56110824 MAP3K1 0.59 7.89 0.4 4.64e-14 Initial pursuit acceleration; CRC cis rs3862260 0.509 rs10923879 chr1:120163831 A/G cg16322792 chr1:120165303 ZNF697 0.47 8.29 0.42 2.91e-15 Systemic lupus erythematosus; CRC cis rs637571 0.676 rs634534 chr11:65665256 A/G cg04055107 chr11:65626734 MUS81;CFL1 -0.43 -5.87 -0.31 1.04e-8 Eosinophil percentage of white cells; CRC trans rs12599106 0.624 rs2173885 chr16:34992749 G/A cg05064044 chr6:292385 DUSP22 -0.74 -10.54 -0.5 1.45e-22 Menopause (age at onset); CRC cis rs7683537 0.673 rs1401363 chr4:185643862 A/G cg04058563 chr4:185651563 MLF1IP 0.72 9.42 0.46 8.51e-19 Systemic lupus erythematosus; CRC cis rs2408955 0.521 rs11168437 chr12:48566156 C/T cg21466736 chr12:48725269 NA -0.52 -7.89 -0.4 4.64e-14 Glycated hemoglobin levels; CRC cis rs290268 0.838 rs290993 chr9:93559572 G/A cg02608019 chr9:93564028 SYK 0.45 7.07 0.36 9.36e-12 Platelet count; CRC cis rs7208859 0.623 rs11652533 chr17:29060601 A/C cg01831904 chr17:28903510 LRRC37B2 -0.61 -6.29 -0.33 1.03e-9 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs611744 0.647 rs689275 chr8:109241822 T/C cg18478394 chr8:109455254 TTC35 0.38 5.94 0.31 7.24e-9 Dupuytren's disease; CRC cis rs7113874 0.524 rs10769925 chr11:8623585 C/T cg02811074 chr11:8615871 STK33 0.33 5.88 0.31 9.85e-9 Body mass index in physically active individuals;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs2295359 1.000 rs11209007 chr1:67619345 C/G cg03340356 chr1:67600835 NA 0.24 5.78 0.3 1.71e-8 Psoriasis; CRC cis rs12545109 0.800 rs2670028 chr8:57423673 G/A cg09654669 chr8:57350985 NA -0.43 -6.56 -0.34 2.1e-10 Obesity-related traits; CRC cis rs13382862 0.862 rs340595 chr2:20889714 A/G cg09074113 chr2:20870087 GDF7 -0.39 -7.53 -0.38 5.08e-13 Abdominal aortic aneurysm; CRC cis rs10504229 0.906 rs72650894 chr8:58179734 C/T cg05313129 chr8:58192883 C8orf71 -0.47 -6.99 -0.36 1.49e-11 Developmental language disorder (linguistic errors); CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg15738916 chr2:102314495 MAP4K4 -0.53 -6.47 -0.34 3.54e-10 Diisocyanate-induced asthma; CRC cis rs459193 1.000 rs465002 chr5:55808475 C/T cg18302225 chr5:55776401 NA 0.44 6.11 0.32 2.83e-9 Coronary artery disease;Type 2 diabetes;Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);Waist-to-hip ratio adjusted for BMI in non-smokers;Waist-to-hip ratio adjusted for BMI (smoking interaction);Waist-to-hip ratio adjusted for body mass index;Waist-hip ratio;Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction); CRC cis rs9311474 0.659 rs7638808 chr3:52572056 C/T cg05573699 chr3:52720067 GNL3;PBRM1 0.41 6.02 0.32 4.58e-9 Electroencephalogram traits; CRC cis rs60871478 0.685 rs34421533 chr7:816638 A/G cg13844804 chr7:814759 HEATR2 0.68 7.43 0.38 9.32e-13 Cerebrospinal P-tau181p levels; CRC cis rs35306767 0.761 rs12771539 chr10:1050653 A/G cg26597838 chr10:835615 NA 0.95 11.2 0.53 6.98e-25 Eosinophil percentage of granulocytes; CRC cis rs7914558 1.000 rs7920251 chr10:104950197 C/T cg15744005 chr10:104629667 AS3MT -0.33 -6.87 -0.35 3.31e-11 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC trans rs66573146 0.808 rs55942328 chr4:6990960 T/G cg07817883 chr1:32538562 TMEM39B 1.24 11.59 0.54 2.8e-26 Granulocyte percentage of myeloid white cells; CRC cis rs501120 0.564 rs1704231 chr10:44691543 C/T cg09554077 chr10:44749378 NA 0.49 6.29 0.33 1.04e-9 Coronary artery disease;Coronary heart disease; CRC cis rs7937682 0.564 rs1944114 chr11:111366460 T/C cg09085632 chr11:111637200 PPP2R1B 0.49 6.5 0.34 2.95e-10 Primary sclerosing cholangitis; CRC cis rs154659 0.961 rs164739 chr16:89667699 C/G cg01710450 chr16:89662404 CPNE7 -0.49 -6.7 -0.35 8.83e-11 Tanning; CRC cis rs523522 0.962 rs4766968 chr12:120947788 G/C cg12219531 chr12:120966889 COQ5 0.69 9.28 0.46 2.36e-18 High light scatter reticulocyte count; CRC cis rs1499614 0.803 rs1922723 chr7:66175063 C/T cg25985355 chr7:65971099 NA -0.52 -5.92 -0.31 7.91e-9 Gout; CRC cis rs17270561 0.609 rs9366629 chr6:25741216 G/A cg16482183 chr6:26056742 HIST1H1C 0.83 10.69 0.51 4.46e-23 Iron status biomarkers; CRC cis rs7487075 0.780 rs10785620 chr12:46737252 G/C cg22049899 chr12:47219821 SLC38A4 0.33 6.39 0.33 5.57e-10 Itch intensity from mosquito bite; CRC cis rs4689388 0.926 rs4458523 chr4:6289986 G/T cg25554036 chr4:6271136 WFS1 -0.47 -7.61 -0.39 2.9e-13 Type 2 diabetes and other traits;Type 2 diabetes; CRC cis rs1950626 0.623 rs2295657 chr14:101430620 A/C cg02351406 chr14:101447389 SNORD114-20;SNORD114-21 0.74 11.52 0.54 5.13e-26 Pelvic organ prolapse (moderate/severe); CRC cis rs10504229 0.593 rs78459635 chr8:58004995 G/T cg02725872 chr8:58115012 NA -0.52 -7.23 -0.37 3.46e-12 Developmental language disorder (linguistic errors); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg05821866 chr1:167905319 DCAF6;BRP44 0.48 6.8 0.35 5.06e-11 Response to antipsychotic treatment; CRC cis rs11098499 0.818 rs7688802 chr4:120451668 G/A cg24375607 chr4:120327624 NA 0.47 7.05 0.36 1.06e-11 Corneal astigmatism; CRC cis rs4889855 0.556 rs11651818 chr17:78530300 A/G cg16591659 chr17:78472290 NA 0.39 5.69 0.3 2.85e-8 Fractional excretion of uric acid; CRC cis rs11864453 0.826 rs2240243 chr16:72137561 A/G cg23815491 chr16:72088622 HP -0.52 -8.06 -0.41 1.42e-14 Fibrinogen levels; CRC cis rs1912483 0.505 rs11079772 chr17:45393739 A/C cg25173405 chr17:45401733 C17orf57 0.58 8.89 0.44 4.26e-17 Coronary artery disease; CRC cis rs34172651 0.917 rs11642302 chr16:24770856 G/A cg06505273 chr16:24850292 NA 0.41 6.29 0.33 9.86e-10 Intelligence (multi-trait analysis); CRC cis rs8180040 0.620 rs6442055 chr3:47110722 A/G cg27129171 chr3:47204927 SETD2 0.73 11.54 0.54 4.22e-26 Colorectal cancer; CRC cis rs853679 0.517 rs9393886 chr6:28050039 T/G cg06470822 chr6:28175283 NA 0.98 13.34 0.59 9.69e-33 Depression; CRC cis rs7937682 0.924 rs11213968 chr11:111527629 G/C cg19812747 chr11:111475976 SIK2 -0.58 -10.06 -0.49 6.12e-21 Primary sclerosing cholangitis; CRC trans rs9929218 1.000 rs13339591 chr16:68809273 T/C cg04657470 chr2:198365150 HSPE1;HSPD1 -0.82 -11.54 -0.54 4.33e-26 Colorectal cancer; CRC cis rs2257205 0.667 rs8080281 chr17:56938558 A/G cg25885038 chr17:56607967 SEPT4 0.53 5.82 0.31 1.43e-8 Pancreatic cancer; CRC cis rs4253772 0.638 rs6007845 chr22:46718417 A/T cg09491104 chr22:46646882 C22orf40 0.48 6.96 0.36 1.81e-11 LDL cholesterol;Cholesterol, total; CRC cis rs6952808 0.792 rs12531315 chr7:1953650 C/G cg20295408 chr7:1910781 MAD1L1 -0.43 -5.99 -0.31 5.41e-9 Bipolar disorder and schizophrenia; CRC cis rs9807841 0.538 rs892086 chr19:10837677 C/T cg17710535 chr19:10819994 QTRT1 0.47 7.43 0.38 9.7e-13 Inflammatory skin disease; CRC cis rs7208859 0.623 rs7220999 chr17:29149298 C/T cg01831904 chr17:28903510 LRRC37B2 -0.66 -6.7 -0.35 9.13e-11 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs3785574 0.962 rs2584628 chr17:61894578 T/C cg23090583 chr17:61904693 PSMC5;FTSJ3 0.63 8.99 0.44 2.01e-17 Height; CRC trans rs7615952 0.741 rs13314845 chr3:125644782 C/T cg02560186 chr11:3602584 NA -0.46 -6.25 -0.33 1.3e-9 Blood pressure (smoking interaction); CRC cis rs4481887 0.676 rs7520659 chr1:248527586 C/A cg26353448 chr1:248524236 OR2T4 -0.34 -7.04 -0.36 1.1e-11 Common traits (Other); CRC trans rs3960554 0.733 rs59170362 chr7:75629267 G/C cg19862616 chr7:65841803 NCRNA00174 0.71 8.44 0.42 1.03e-15 Eotaxin levels; CRC cis rs2228479 0.850 rs17227064 chr16:89816314 A/G cg19635926 chr16:89946313 TCF25 0.66 5.97 0.31 6.1e-9 Skin colour saturation; CRC cis rs7954584 0.567 rs11612028 chr12:122387872 C/G cg21171335 chr12:122356390 WDR66 0.4 6.14 0.32 2.43e-9 Mean corpuscular volume; CRC cis rs514406 0.825 rs6695819 chr1:53223366 T/C cg25767906 chr1:53392781 SCP2 0.45 7.12 0.37 6.95e-12 Monocyte count; CRC cis rs2404602 0.536 rs11072599 chr15:76774508 T/C cg22467129 chr15:76604101 ETFA -0.44 -7.63 -0.39 2.56e-13 Blood metabolite levels; CRC cis rs6460942 1.000 rs6460936 chr7:12404913 T/C cg20607287 chr7:12443886 VWDE -0.65 -6.65 -0.34 1.25e-10 Coronary artery disease; CRC cis rs11203032 0.614 rs11203025 chr10:90955474 A/C cg16672925 chr10:90967113 CH25H 0.45 5.74 0.3 2.17e-8 Heart failure; CRC cis rs7953508 0.506 rs1316740 chr12:93968288 C/A cg18151635 chr12:93972918 NA -0.8 -11.58 -0.54 2.97e-26 Pubertal anthropometrics; CRC trans rs4263408 0.934 rs9683743 chr4:39703194 A/C cg18864399 chr15:73345368 NEO1 -0.42 -6.23 -0.32 1.41e-9 Plasma amyloid beta peptide concentrations (ABx-40); CRC cis rs28386778 0.799 rs2665836 chr17:61898135 C/A cg06873352 chr17:61820015 STRADA 0.8 15.26 0.64 4.12e-40 Prudent dietary pattern; CRC cis rs1707322 0.721 rs10890333 chr1:46100322 T/C cg03146154 chr1:46216737 IPP 0.67 9.82 0.48 4.04e-20 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs4713118 0.955 rs9468206 chr6:27690453 G/T cg19041857 chr6:27730383 NA -0.43 -6.01 -0.31 4.81e-9 Parkinson's disease; CRC cis rs4727027 0.933 rs1468369 chr7:148839840 G/C cg23583168 chr7:148888333 NA -0.88 -14.83 -0.63 1.87e-38 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC trans rs113835537 0.627 rs4630309 chr11:66333072 A/C cg25131818 chr5:173000177 NA 0.58 6.12 0.32 2.7e-9 Airway imaging phenotypes; CRC cis rs35883536 1.000 rs4907918 chr1:101094609 A/G cg14515779 chr1:101123966 NA 0.44 8.57 0.43 3.97e-16 Monocyte count; CRC cis rs9300255 0.722 rs28458312 chr12:123863265 G/T cg00376283 chr12:123451042 ABCB9 -0.51 -6.54 -0.34 2.32e-10 Neutrophil percentage of white cells; CRC cis rs6701037 0.748 rs11583687 chr1:175132049 A/C cg17845761 chr1:175162550 KIAA0040 0.29 5.99 0.31 5.36e-9 Alcohol dependence; CRC cis rs11628318 0.515 rs2093259 chr14:103145646 T/A cg12046867 chr14:103022105 NA 0.41 5.83 0.31 1.29e-8 Platelet count; CRC cis rs375066 0.623 rs1549959 chr19:44354486 G/A cg19542119 chr19:44331823 ZNF283 0.4 5.61 0.3 4.24e-8 Breast cancer; CRC cis rs6460942 0.915 rs17444044 chr7:12458736 A/G cg06484146 chr7:12443880 VWDE -0.78 -8.1 -0.41 1.11e-14 Coronary artery disease; CRC cis rs597539 0.615 rs583182 chr11:68678634 C/T cg06112835 chr11:68658793 MRPL21 0.48 7.96 0.4 2.74e-14 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC trans rs2303319 0.504 rs2175142 chr2:162450124 T/C cg15664909 chr17:685709 GLOD4;RNMTL1 -0.67 -5.96 -0.31 6.48e-9 Cognitive function; CRC cis rs3087591 0.922 rs2905788 chr17:29480295 C/T cg24425628 chr17:29625626 OMG;NF1 0.86 15.83 0.66 2.29e-42 Hip circumference; CRC cis rs12474201 0.832 rs4952843 chr2:46957845 A/G cg06386533 chr2:46925753 SOCS5 0.79 13.13 0.59 5.83e-32 Height; CRC cis rs449789 0.857 rs606833 chr6:159717776 T/A cg14500486 chr6:159655392 FNDC1 -0.48 -7.29 -0.37 2.38e-12 Pulse pressure; CRC cis rs10751667 0.666 rs7396473 chr11:966181 T/C cg23136738 chr11:925521 AP2A2 -0.42 -7.09 -0.36 8.19e-12 Alzheimer's disease (late onset); CRC cis rs853679 0.517 rs9295761 chr6:28147987 A/G cg02683197 chr6:28174875 NA 0.89 10.93 0.52 6.43e-24 Depression; CRC cis rs1799949 0.929 rs12937015 chr17:41307473 A/C cg01879757 chr17:41196368 BRCA1 -0.44 -6.72 -0.35 8.23e-11 Menopause (age at onset); CRC trans rs2303319 0.504 rs12467625 chr2:162603387 C/A cg22677401 chr17:46026860 NA -0.67 -6.07 -0.32 3.57e-9 Cognitive function; CRC cis rs501120 0.584 rs629213 chr10:44736784 C/T cg09554077 chr10:44749378 NA 0.76 8.38 0.42 1.59e-15 Coronary artery disease;Coronary heart disease; CRC trans rs10982213 0.830 rs2274163 chr9:117188714 C/T cg21192376 chr14:53020168 GPR137C;TXNDC16 0.37 6.15 0.32 2.23e-9 Interleukin-6 levels; CRC cis rs10504229 0.609 rs66477547 chr8:58105763 A/C cg02725872 chr8:58115012 NA -0.65 -11.13 -0.52 1.27e-24 Developmental language disorder (linguistic errors); CRC cis rs3126085 0.935 rs4845736 chr1:152175551 G/A cg09127314 chr1:152161683 NA 0.5 6.36 0.33 6.76e-10 Atopic dermatitis; CRC cis rs904251 0.523 rs2797794 chr6:37480604 T/C cg25019722 chr6:37503610 NA -0.47 -8.66 -0.43 2.1e-16 Cognitive performance; CRC cis rs4711350 0.749 rs7752348 chr6:33718252 C/G cg07979401 chr6:33739406 LEMD2 -0.43 -5.67 -0.3 3.1e-8 Schizophrenia; CRC cis rs908922 0.676 rs2146120 chr1:152504200 A/T cg23254163 chr1:152506842 NA 0.43 8.07 0.41 1.33e-14 Hair morphology; CRC cis rs6502050 0.835 rs4789751 chr17:80092373 G/T cg22110888 chr17:80059540 CCDC57 0.39 6.23 0.32 1.41e-9 Life satisfaction; CRC trans rs11098499 0.615 rs28551750 chr4:120264901 C/T cg25214090 chr10:38739885 LOC399744 0.54 8.57 0.43 4.07e-16 Corneal astigmatism; CRC cis rs344364 0.602 rs2437745 chr16:1908431 G/C cg09830162 chr16:1889614 FAHD1;C16orf73 0.56 8.35 0.42 1.92e-15 Glomerular filtration rate in chronic kidney disease; CRC cis rs7224737 1.000 rs1122326 chr17:40274873 A/C cg20291162 chr17:40259547 DHX58 -0.52 -7.06 -0.36 9.65e-12 Fibrinogen levels; CRC cis rs67311347 1.000 rs11707673 chr3:40450604 C/A cg09455208 chr3:40491958 NA 0.47 9.1 0.45 8.66e-18 Renal cell carcinoma; CRC cis rs875971 0.571 rs160641 chr7:65577346 G/A cg18876405 chr7:65276391 NA -0.44 -6.15 -0.32 2.28e-9 Aortic root size; CRC cis rs853679 0.517 rs6941992 chr6:28106141 T/C cg06470822 chr6:28175283 NA 1.0 13.33 0.59 1.06e-32 Depression; CRC cis rs929354 0.772 rs1182364 chr7:157017912 T/C cg05182265 chr7:156933206 UBE3C 0.77 14.61 0.63 1.28e-37 Body mass index; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg17491185 chr1:23811274 ASAP3 0.39 5.99 0.31 5.41e-9 Liver disease severity in Alagille syndrome; CRC cis rs11764590 0.694 rs10276536 chr7:2086960 C/T cg14004847 chr7:1930337 MAD1L1 -0.44 -6.1 -0.32 2.94e-9 Neuroticism; CRC trans rs9388451 0.903 rs7758115 chr6:126061502 C/T cg05039488 chr6:79577232 IRAK1BP1 -0.56 -8.62 -0.43 2.94e-16 Brugada syndrome; CRC cis rs9733 0.596 rs2175615 chr1:150624101 A/G cg18016565 chr1:150552671 MCL1 0.46 6.74 0.35 6.91e-11 Tonsillectomy; CRC cis rs1552244 1.000 rs113134644 chr3:10086286 G/A cg00166722 chr3:10149974 C3orf24 0.66 9.13 0.45 7.29e-18 Alzheimer's disease; CRC cis rs904251 0.861 rs1757169 chr6:37487076 G/T cg01843034 chr6:37503916 NA -0.48 -8.8 -0.44 7.73e-17 Cognitive performance; CRC trans rs2797160 0.651 rs1343121 chr6:126036184 C/T cg05039488 chr6:79577232 IRAK1BP1 0.56 8.53 0.43 5.29e-16 Endometrial cancer; CRC trans rs11031096 0.702 rs34356743 chr11:4153891 T/C cg22978087 chr8:24814126 NEFL 0.33 6.08 0.32 3.37e-9 Mean corpuscular volume;Mean corpuscular hemoglobin; CRC cis rs3862030 0.810 rs11593710 chr10:104328719 A/C cg11453585 chr10:104263688 ACTR1A;SUFU -0.83 -15.06 -0.64 2.38e-39 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for body mass index; CRC cis rs860295 0.702 rs10908465 chr1:155389688 C/T cg02153340 chr1:155202674 NA -0.57 -6.77 -0.35 5.96e-11 Body mass index; CRC cis rs7224685 0.501 rs2727064 chr17:3934101 A/G cg09695851 chr17:3907499 NA 0.74 13.31 0.59 1.25e-32 Type 2 diabetes; CRC cis rs514406 0.929 rs12354395 chr1:53327663 A/G cg24675658 chr1:53192096 ZYG11B -0.57 -8.48 -0.42 7.78e-16 Monocyte count; CRC cis rs6445967 0.695 rs2292675 chr3:58235727 T/C cg23715586 chr3:58305044 RPP14 0.38 5.89 0.31 9.79e-9 Platelet count; CRC cis rs2404602 0.735 rs2436994 chr15:76801063 G/C cg03037974 chr15:76606532 NA -0.43 -6.61 -0.34 1.51e-10 Blood metabolite levels; CRC cis rs1552244 0.572 rs59132826 chr3:10169725 G/A cg08888203 chr3:10149979 C3orf24 0.71 8.58 0.43 3.91e-16 Alzheimer's disease; CRC cis rs2760061 0.599 rs644794 chr1:228148670 T/C cg02753203 chr1:228287806 NA -0.62 -9.12 -0.45 7.68e-18 Diastolic blood pressure; CRC cis rs1799949 0.965 rs799908 chr17:41278916 A/G cg07153921 chr17:41440717 NA -0.38 -5.74 -0.3 2.13e-8 Menopause (age at onset); CRC cis rs2153535 0.580 rs2183112 chr6:8528212 G/A cg21535247 chr6:8435926 SLC35B3 0.48 7.35 0.38 1.6e-12 Motion sickness; CRC trans rs1814175 0.791 rs10839395 chr11:49846274 G/T cg15704280 chr7:45808275 SEPT13 -0.96 -18.19 -0.71 1.21e-51 Height; CRC cis rs9517320 0.534 rs3858776 chr13:99161457 C/T cg07423050 chr13:99094983 FARP1 -0.5 -7.37 -0.38 1.38e-12 Longevity; CRC cis rs294883 0.821 rs294899 chr6:159672455 C/T cg14500486 chr6:159655392 FNDC1 -0.37 -6.15 -0.32 2.27e-9 Coronary artery disease; CRC cis rs453301 0.686 rs3895823 chr8:8873646 T/C cg08975724 chr8:8085496 FLJ10661 -0.37 -5.62 -0.3 4.06e-8 Joint mobility (Beighton score); CRC cis rs17711722 0.522 rs6957759 chr7:65271785 A/G cg07294406 chr7:64700536 NA 0.37 6.0 0.31 5.1e-9 Calcium levels; CRC cis rs11690935 1.000 rs312925 chr2:172563922 G/A cg13550731 chr2:172543902 DYNC1I2 -1.09 -18.96 -0.72 1.04e-54 Schizophrenia; CRC cis rs243505 0.898 rs243532 chr7:148412371 A/G cg09806900 chr7:148480153 CUL1 -0.43 -5.95 -0.31 7.02e-9 Inflammatory bowel disease;Crohn's disease; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg20237707 chr13:111719772 NA -0.42 -6.66 -0.34 1.15e-10 Myopia (pathological); CRC cis rs2153535 0.580 rs7341383 chr6:8470634 A/C cg21535247 chr6:8435926 SLC35B3 0.5 7.53 0.38 4.89e-13 Motion sickness; CRC cis rs904251 0.523 rs10807184 chr6:37483713 C/T cg01843034 chr6:37503916 NA -0.39 -7.12 -0.37 6.8e-12 Cognitive performance; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg12609600 chr11:1595974 HCCA2;LOC338651 0.36 6.04 0.32 4.25e-9 Liver disease severity in Alagille syndrome; CRC cis rs992157 0.835 rs10932769 chr2:219147245 T/G cg04880052 chr2:219191631 PNKD -0.44 -6.95 -0.36 2e-11 Colorectal cancer; CRC cis rs9359856 0.564 rs17735590 chr6:90330268 G/C cg13799429 chr6:90582589 CASP8AP2 -0.72 -7.85 -0.4 5.97e-14 Bipolar disorder; CRC trans rs2303319 0.504 rs62187646 chr2:162445488 T/C cg12500891 chr11:57225987 NA -0.67 -6.03 -0.32 4.51e-9 Cognitive function; CRC trans rs9747201 0.889 rs4789784 chr17:80179213 G/A cg07393940 chr7:158741817 NA 0.51 7.23 0.37 3.3e-12 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs7264396 0.790 rs6121018 chr20:34249060 C/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.61 -10.31 -0.49 8.99e-22 Total cholesterol levels; CRC cis rs372883 0.869 rs2027605 chr21:30726773 A/G cg24692254 chr21:30365293 RNF160 0.39 5.94 0.31 7.35e-9 Pancreatic cancer; CRC cis rs67311347 0.911 rs6773917 chr3:40469254 G/T cg24209194 chr3:40518798 ZNF619 0.41 6.28 0.33 1.08e-9 Renal cell carcinoma; CRC cis rs10504229 1.000 rs57941207 chr8:58169821 A/G cg02290350 chr8:58132656 NA -0.41 -5.74 -0.3 2.21e-8 Developmental language disorder (linguistic errors); CRC cis rs477895 0.838 rs35090903 chr11:64000598 C/T cg04317338 chr11:64019027 PLCB3 0.7 8.59 0.43 3.49e-16 Mean platelet volume; CRC cis rs7666738 0.830 rs79075162 chr4:98960674 A/T cg05340658 chr4:99064831 C4orf37 0.61 9.54 0.47 3.45e-19 Colonoscopy-negative controls vs population controls; CRC cis rs7312933 0.558 rs11181463 chr12:42763636 C/T cg11827402 chr12:42719852 PPHLN1;ZCRB1 0.66 9.71 0.47 8.87e-20 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CRC trans rs7615952 0.512 rs4234285 chr3:125404477 G/A cg00769240 chr8:12517080 NA -0.74 -10.38 -0.5 5.02e-22 Blood pressure (smoking interaction); CRC cis rs4713118 0.539 rs200988 chr6:27819353 A/C cg20933634 chr6:27740509 NA 0.51 7.28 0.37 2.46e-12 Parkinson's disease; CRC cis rs9372498 0.505 rs56406560 chr6:118991787 G/A cg22561889 chr6:118971681 C6orf204 0.45 5.95 0.31 6.93e-9 Diastolic blood pressure; CRC cis rs2180341 1.000 rs6569486 chr6:127708424 A/C cg24812749 chr6:127587940 RNF146 0.97 13.53 0.6 1.75e-33 Breast cancer; CRC cis rs6761276 0.752 rs12477866 chr2:113835908 C/T cg09040174 chr2:113837401 NA 0.64 10.17 0.49 2.58e-21 Protein quantitative trait loci; CRC cis rs1552244 0.572 rs6785976 chr3:10168647 A/G cg13047869 chr3:10149882 C3orf24 0.53 6.49 0.34 3.21e-10 Alzheimer's disease; CRC cis rs709400 0.930 rs10149249 chr14:104047757 C/T cg24130564 chr14:104152367 KLC1 -0.4 -5.73 -0.3 2.33e-8 Body mass index; CRC cis rs10504229 0.775 rs55825382 chr8:58157605 G/A cg05313129 chr8:58192883 C8orf71 -0.48 -6.18 -0.32 1.9e-9 Developmental language disorder (linguistic errors); CRC cis rs2380220 1.000 rs9400318 chr6:95972381 T/A cg04719120 chr6:96025338 MANEA 0.61 6.99 0.36 1.58e-11 Behavioural disinhibition (generation interaction); CRC cis rs7843479 0.582 rs11135743 chr8:21803008 A/G cg16476235 chr8:21771668 DOK2 0.35 6.0 0.31 5.3e-9 Mean corpuscular volume; CRC cis rs769267 1.000 rs2301669 chr19:19453560 C/A cg02546618 chr19:19431379 KIAA0892;SF4 -0.46 -6.46 -0.34 3.86e-10 Tonsillectomy; CRC cis rs1552244 0.572 rs68013239 chr3:10165711 G/T cg08888203 chr3:10149979 C3orf24 0.71 8.57 0.43 4.18e-16 Alzheimer's disease; CRC cis rs11758351 0.866 rs77205516 chr6:26205356 T/A cg01420254 chr6:26195488 NA 0.8 8.79 0.44 8.31e-17 Gout;Renal underexcretion gout; CRC cis rs9487051 0.676 rs2222392 chr6:109602303 T/C cg12927641 chr6:109611667 NA -0.38 -6.75 -0.35 6.72e-11 Reticulocyte fraction of red cells; CRC cis rs672059 0.967 rs514183 chr1:183163174 A/C ch.1.3577855R chr1:183094577 LAMC1 0.51 7.35 0.38 1.55e-12 Hypertriglyceridemia; CRC cis rs6089584 0.850 rs6142939 chr20:60627729 A/G cg13770153 chr20:60521292 NA -0.6 -9.16 -0.45 5.57e-18 Body mass index; CRC cis rs2153535 0.580 rs9328479 chr6:8519646 A/G cg21535247 chr6:8435926 SLC35B3 0.49 7.48 0.38 6.73e-13 Motion sickness; CRC cis rs28386778 0.897 rs4638645 chr17:61828349 T/C cg22520471 chr17:61851767 DDX42;CCDC47 0.74 11.57 0.54 3.22e-26 Prudent dietary pattern; CRC cis rs4713118 0.662 rs149961 chr6:28015569 A/C cg18032046 chr6:28092343 ZSCAN16 -0.47 -6.02 -0.31 4.75e-9 Parkinson's disease; CRC cis rs9549367 0.713 rs9577211 chr13:113830718 G/C cg24300038 chr13:113819356 PROZ -0.47 -5.89 -0.31 9.4e-9 Platelet distribution width; CRC cis rs17270561 0.609 rs7754296 chr6:25744878 A/G cg17691542 chr6:26056736 HIST1H1C 0.71 8.98 0.44 2.08e-17 Iron status biomarkers; CRC cis rs7998202 0.667 rs282586 chr13:113351474 T/C cg02820901 chr13:113351484 ATP11A 0.71 7.44 0.38 9.05e-13 Glycated hemoglobin levels; CRC cis rs1577917 0.917 rs1579886 chr6:86557191 A/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.51 -6.59 -0.34 1.76e-10 Response to antipsychotic treatment; CRC trans rs2243480 1.000 rs160642 chr7:65558373 C/T cg10756647 chr7:56101905 PSPH 0.69 7.49 0.38 6.21e-13 Diabetic kidney disease; CRC cis rs7493 0.516 rs13233527 chr7:95068795 T/C cg19678392 chr7:94953810 PON1 -0.43 -5.87 -0.31 1.06e-8 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs6752107 1.000 rs2241879 chr2:234183468 G/A cg07618928 chr2:234183455 ATG16L1;SCARNA5 0.67 11.65 0.54 1.73e-26 Crohn's disease;Inflammatory bowel disease; CRC cis rs644799 0.542 rs10831415 chr11:95466159 A/G cg03916912 chr11:95522834 CEP57;FAM76B 0.66 10.15 0.49 2.98e-21 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs965469 0.779 rs1884563 chr20:3335540 T/C cg25506879 chr20:3388711 C20orf194 -0.37 -5.76 -0.3 1.94e-8 IFN-related cytopenia; CRC cis rs7072216 0.763 rs10883090 chr10:100167236 G/C cg26618903 chr10:100175079 PYROXD2 -0.55 -9.26 -0.45 2.73e-18 Metabolite levels; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg20646317 chr12:50794494 LARP4 0.47 6.02 0.31 4.58e-9 Thyroid stimulating hormone; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg00415497 chr22:50329860 NA 0.44 6.2 0.32 1.65e-9 Response to antipsychotic treatment; CRC cis rs10540 1.000 rs12801271 chr11:508720 C/T cg19913688 chr11:428466 ANO9 -0.69 -7.03 -0.36 1.22e-11 Body mass index; CRC trans rs2303319 0.504 rs62187597 chr2:162398263 A/T cg18122310 chr12:50236657 BCDIN3D -0.72 -6.04 -0.32 4.15e-9 Cognitive function; CRC cis rs4654899 1.000 rs10916938 chr1:21446883 A/G cg02927042 chr1:21476669 EIF4G3 -0.47 -7.61 -0.39 2.85e-13 Superior frontal gyrus grey matter volume; CRC cis rs4363385 0.755 rs516198 chr1:153026196 T/C cg25856811 chr1:152973957 SPRR3 -0.27 -7.45 -0.38 8.13e-13 Inflammatory skin disease; CRC trans rs6952808 0.573 rs12668848 chr7:2020995 G/A cg04565464 chr8:145669602 NFKBIL2 0.43 6.55 0.34 2.18e-10 Bipolar disorder and schizophrenia; CRC cis rs7666738 0.830 rs6854919 chr4:98947326 C/T cg03676636 chr4:99064102 C4orf37 0.2 5.81 0.31 1.45e-8 Colonoscopy-negative controls vs population controls; CRC cis rs6963495 0.818 rs73190181 chr7:105162907 A/C cg02135003 chr7:105160482 PUS7 -0.9 -12.2 -0.56 1.71e-28 Bipolar disorder (body mass index interaction); CRC cis rs4689388 0.890 rs1801206 chr4:6302707 C/T cg00701064 chr4:6280414 WFS1 0.78 13.83 0.61 1.26e-34 Type 2 diabetes and other traits;Type 2 diabetes; CRC cis rs4478858 0.735 rs4949384 chr1:31792141 A/G cg00250761 chr1:31883323 NA -0.4 -7.41 -0.38 1.08e-12 Alcohol dependence; CRC cis rs4803480 0.872 rs2058149 chr19:42086665 C/G cg08478046 chr19:42093086 CEACAM21 -0.31 -5.61 -0.3 4.28e-8 Schizophrenia; CRC cis rs58688157 0.660 rs12797496 chr11:583767 C/T cg09218773 chr11:619014 MUPCDH -0.42 -5.93 -0.31 7.54e-9 Systemic lupus erythematosus; CRC cis rs116095464 0.558 rs28635197 chr5:279071 T/C cg22857025 chr5:266934 NA -1.24 -16.6 -0.68 2.3e-45 Breast cancer; CRC cis rs763121 0.853 rs6001173 chr22:39015302 A/G cg06022373 chr22:39101656 GTPBP1 0.81 13.6 0.6 9.75e-34 Menopause (age at onset); CRC cis rs10499694 0.868 rs1470749 chr7:50578023 G/T cg18232548 chr7:50535776 DDC -0.39 -5.9 -0.31 9.13e-9 Body mass index; CRC cis rs4843747 0.605 rs4072779 chr16:88107290 C/T cg03395651 chr16:88107091 BANP 0.6 8.16 0.41 7.06e-15 Menopause (age at onset); CRC cis rs6460942 1.000 rs6460935 chr7:12401317 A/T cg06484146 chr7:12443880 VWDE -0.77 -7.65 -0.39 2.2e-13 Coronary artery disease; CRC cis rs6586163 0.872 rs1926201 chr10:90746360 G/C cg13456138 chr10:90753195 FAS -0.43 -6.44 -0.33 4.19e-10 Chronic lymphocytic leukemia; CRC trans rs61931739 0.500 rs7979240 chr12:34509026 C/T cg26384229 chr12:38710491 ALG10B 0.67 8.79 0.44 8.39e-17 Morning vs. evening chronotype; CRC cis rs780096 0.526 rs1647266 chr2:27693485 T/C cg02592271 chr2:27665507 KRTCAP3 -0.28 -6.58 -0.34 1.83e-10 Total body bone mineral density; CRC cis rs1971762 0.527 rs6580958 chr12:54073483 A/G cg06632207 chr12:54070931 ATP5G2 0.45 7.69 0.39 1.74e-13 Height; CRC cis rs7312774 0.748 rs1861746 chr12:107301518 G/A cg16260113 chr12:107380972 MTERFD3 0.77 7.69 0.39 1.77e-13 Severe influenza A (H1N1) infection; CRC cis rs863345 0.584 rs10797024 chr1:158497163 G/A cg12129480 chr1:158549410 OR10X1 -0.29 -5.95 -0.31 6.94e-9 Pneumococcal bacteremia; CRC cis rs13108904 0.518 rs4974603 chr4:1343168 C/T cg00684032 chr4:1343700 KIAA1530 0.57 8.09 0.41 1.16e-14 Obesity-related traits; CRC trans rs11165623 0.564 rs7523597 chr1:97000989 A/G cg10631902 chr5:14652156 NA -0.4 -6.83 -0.35 4.13e-11 Hip circumference;Waist circumference; CRC cis rs7927592 0.956 rs10896337 chr11:68284236 T/C cg16797656 chr11:68205561 LRP5 0.37 5.91 0.31 8.45e-9 Total body bone mineral density; CRC cis rs2576037 0.899 rs12955429 chr18:44585484 C/T cg24750912 chr18:44543259 TCEB3CL;KATNAL2 -0.29 -5.64 -0.3 3.59e-8 Personality dimensions; CRC cis rs6582630 0.519 rs12578283 chr12:38325349 A/T cg13010199 chr12:38710504 ALG10B 0.46 6.18 0.32 1.88e-9 Drug-induced liver injury (flucloxacillin); CRC cis rs7412746 0.621 rs7518156 chr1:150945794 A/C cg17724175 chr1:150552817 MCL1 0.43 6.55 0.34 2.19e-10 Melanoma; CRC trans rs61931739 0.500 rs10844846 chr12:34394611 C/G cg26384229 chr12:38710491 ALG10B 0.61 9.02 0.45 1.59e-17 Morning vs. evening chronotype; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg07042827 chr14:90849692 NA 0.47 6.62 0.34 1.48e-10 Response to antipsychotic treatment; CRC cis rs3749237 0.595 rs1568661 chr3:49520958 A/G cg07636037 chr3:49044803 WDR6 0.54 7.99 0.4 2.35e-14 Resting heart rate; CRC cis rs1799949 0.896 rs8176086 chr17:41274778 G/A cg25072359 chr17:41440525 NA 0.46 6.9 0.36 2.64e-11 Menopause (age at onset); CRC cis rs9372498 0.536 rs9320660 chr6:118956827 A/T cg18833306 chr6:118973337 C6orf204 0.46 5.88 0.31 1.01e-8 Diastolic blood pressure; CRC cis rs7552404 1.000 rs7516226 chr1:76234257 G/A cg22875332 chr1:76189707 ACADM 0.7 9.45 0.46 6.6e-19 Blood metabolite levels;Acylcarnitine levels; CRC cis rs2204008 0.619 rs11178987 chr12:38201258 C/T cg13010199 chr12:38710504 ALG10B -0.41 -5.98 -0.31 5.88e-9 Bladder cancer; CRC cis rs1451375 0.572 rs745042 chr7:50544138 A/G cg14593290 chr7:50529359 DDC -0.63 -8.31 -0.42 2.63e-15 Malaria; CRC cis rs7781266 0.640 rs62472376 chr7:133100276 T/C cg03336402 chr7:133662267 EXOC4 0.51 5.98 0.31 5.89e-9 Educational attainment (college completion); CRC trans rs10411161 0.752 rs10404812 chr19:52400691 T/C cg22319618 chr22:45562946 NUP50 -0.58 -6.01 -0.31 5.02e-9 Breast cancer; CRC cis rs4969178 0.930 rs2292644 chr17:76394449 C/T cg20026190 chr17:76395443 PGS1 0.4 6.22 0.32 1.53e-9 HDL cholesterol levels; CRC cis rs3736485 0.934 rs2899475 chr15:51883051 C/T cg08986416 chr15:51914746 DMXL2 -0.46 -6.56 -0.34 2.11e-10 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC trans rs1814175 0.645 rs11040535 chr11:49808669 C/T cg21153622 chr11:89784906 NA -0.4 -6.14 -0.32 2.34e-9 Height; CRC cis rs1401999 1.000 rs6804242 chr3:183659463 A/T cg05044414 chr3:183734942 ABCC5 0.48 8.29 0.42 2.89e-15 Anterior chamber depth; CRC trans rs1656966 1.000 rs1656966 chr3:186466252 C/T cg21071989 chr15:31508272 NA 0.42 6.24 0.33 1.36e-9 Myopia (pathological); CRC cis rs2153535 0.580 rs4960411 chr6:8438231 C/G cg21535247 chr6:8435926 SLC35B3 0.48 7.26 0.37 2.78e-12 Motion sickness; CRC cis rs2019137 0.560 rs6707386 chr2:113981022 G/A cg12889195 chr2:113992843 PAX8;LOC440839;LOC654433 0.68 10.34 0.5 7.2e-22 Lymphocyte counts; CRC cis rs6502050 0.761 rs13949 chr17:80059596 T/C cg19223190 chr17:80058835 NA -0.49 -7.8 -0.4 8.33e-14 Life satisfaction; CRC cis rs13191362 0.935 rs34709632 chr6:163048380 A/G cg23758597 chr6:163146217 PARK2 -0.66 -6.48 -0.34 3.28e-10 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs2204008 0.806 rs35534445 chr12:38279093 C/T cg26384229 chr12:38710491 ALG10B 0.67 9.05 0.45 1.29e-17 Bladder cancer; CRC cis rs1499614 1.000 rs2659913 chr7:66157336 T/A cg25985355 chr7:65971099 NA -0.52 -5.92 -0.31 7.91e-9 Gout; CRC cis rs12580194 0.593 rs11171431 chr12:55757609 G/T cg19537932 chr12:55886519 OR6C68 -0.67 -8.83 -0.44 6.47e-17 Cancer; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg07582382 chr10:15001273 MEIG1 0.5 6.9 0.36 2.76e-11 Response to antipsychotic treatment; CRC cis rs6088580 0.634 rs6120642 chr20:33012531 A/G cg24642439 chr20:33292090 TP53INP2 0.37 6.21 0.32 1.55e-9 Glomerular filtration rate (creatinine); CRC cis rs6545883 0.965 rs7421663 chr2:61753786 C/T cg15711740 chr2:61764176 XPO1 -0.51 -7.1 -0.36 7.78e-12 Tuberculosis; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg18462141 chr11:49872414 NA -0.33 -6.06 -0.32 3.71e-9 Liver disease severity in Alagille syndrome; CRC cis rs514406 0.679 rs61768344 chr1:53229274 G/A cg08859206 chr1:53392774 SCP2 0.63 10.05 0.48 6.71e-21 Monocyte count; CRC cis rs17270561 0.562 rs12199626 chr6:26013604 G/A cg16482183 chr6:26056742 HIST1H1C 1.06 12.73 0.57 1.91e-30 Iron status biomarkers; CRC cis rs9768139 0.935 rs10155946 chr7:158122116 C/T cg06219351 chr7:158114137 PTPRN2 0.44 6.51 0.34 2.73e-10 Calcium levels; CRC cis rs9648716 1.000 rs10232600 chr7:140619317 A/C cg10747023 chr7:140774559 NA 0.46 6.03 0.32 4.51e-9 Type 2 diabetes; CRC cis rs11785400 1.000 rs6988393 chr8:143740596 A/G cg24634471 chr8:143751801 JRK 0.53 7.55 0.38 4.46e-13 Schizophrenia; CRC cis rs4964805 0.865 rs3935416 chr12:104206955 C/G cg02344784 chr12:104178138 NT5DC3 0.53 8.07 0.41 1.29e-14 Attention deficit hyperactivity disorder; CRC cis rs11628318 0.614 rs72635192 chr14:103128646 C/T cg08075719 chr14:103021372 NA 0.65 7.55 0.38 4.22e-13 Platelet count; CRC cis rs13118159 0.550 rs2878607 chr4:1353310 G/C cg20887711 chr4:1340912 KIAA1530 0.75 10.96 0.52 4.91e-24 Longevity; CRC cis rs6964587 1.000 rs11772102 chr7:91558326 A/T cg17063962 chr7:91808500 NA -0.77 -12.97 -0.58 2.46e-31 Breast cancer; CRC cis rs763014 0.966 rs7185390 chr16:666382 A/G cg00908189 chr16:619842 PIGQ 0.67 10.93 0.52 6.36e-24 Height; CRC trans rs12699921 0.632 rs2691601 chr7:17875431 C/T cg02066331 chr6:17282778 RBM24 -0.37 -6.41 -0.33 5.08e-10 Fibrinogen levels; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg26814432 chr1:114302134 PHTF1 0.42 6.11 0.32 2.79e-9 Response to antipsychotic treatment; CRC cis rs17376456 0.877 rs9314095 chr5:93425495 T/C cg25358565 chr5:93447407 FAM172A 1.02 10.47 0.5 2.42e-22 Diabetic retinopathy; CRC cis rs16867321 0.507 rs2013577 chr2:181370505 C/T cg23363182 chr2:181467187 NA -0.54 -7.97 -0.4 2.7e-14 Obesity; CRC cis rs754466 0.914 rs4595491 chr10:79685833 G/A cg17075019 chr10:79541650 NA -0.72 -10.09 -0.49 4.82e-21 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs7843479 0.543 rs10866823 chr8:21781629 C/T cg08288130 chr8:21771540 DOK2 0.3 6.04 0.32 4.15e-9 Mean corpuscular volume; CRC cis rs12130219 0.500 rs4845743 chr1:152184149 A/G cg26879891 chr1:152191343 HRNR -0.31 -5.99 -0.31 5.48e-9 Inflammatory skin disease; CRC cis rs514406 0.644 rs7552663 chr1:53204352 C/T cg08859206 chr1:53392774 SCP2 0.41 6.49 0.34 3.21e-10 Monocyte count; CRC cis rs875971 0.862 rs6945775 chr7:65968974 G/A cg18252515 chr7:66147081 NA -0.42 -6.14 -0.32 2.37e-9 Aortic root size; CRC cis rs3741151 0.892 rs76854106 chr11:73027110 G/A cg17517138 chr11:73019481 ARHGEF17 0.99 9.05 0.45 1.26e-17 GIP levels in response to oral glucose tolerance test (120 minutes); CRC cis rs7605827 0.930 rs7578787 chr2:15655119 T/C cg19274914 chr2:15703543 NA 0.4 6.0 0.31 5.16e-9 Educational attainment (years of education); CRC cis rs62229266 0.659 rs2255734 chr21:37411909 T/C cg12218747 chr21:37451666 NA -0.36 -6.21 -0.32 1.63e-9 Mitral valve prolapse; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg12051359 chr8:120886151 DEPDC6 0.44 6.32 0.33 8.41e-10 Intelligence (multi-trait analysis); CRC cis rs7615952 0.641 rs7632497 chr3:125783086 A/C cg05084668 chr3:125655381 ALG1L -0.46 -6.53 -0.34 2.44e-10 Blood pressure (smoking interaction); CRC cis rs2742417 0.603 rs2742455 chr3:45767116 A/G cg04837898 chr3:45731254 SACM1L -0.48 -7.69 -0.39 1.74e-13 Response to anti-depressant treatment in major depressive disorder; CRC trans rs208520 0.874 rs208518 chr6:66948501 C/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.89 11.46 0.53 7.91e-26 Exhaled nitric oxide output; CRC cis rs2949837 0.581 rs2965074 chr7:45983129 G/T cg04727332 chr7:45960243 IGFBP3 0.36 5.73 0.3 2.28e-8 Sitting height ratio; CRC cis rs72781680 0.821 rs72790329 chr2:24129277 A/G cg08917208 chr2:24149416 ATAD2B 0.55 6.73 0.35 7.73e-11 Lymphocyte counts; CRC cis rs2310173 0.612 rs3819369 chr2:102632582 T/A cg20856504 chr2:102616538 IL1R2 0.39 6.18 0.32 1.92e-9 Ankylosing spondylitis;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined);Ulcerative colitis; CRC cis rs9467773 0.572 rs9467737 chr6:26381630 T/C cg09904177 chr6:26538194 HMGN4 -0.43 -5.76 -0.3 1.92e-8 Intelligence (multi-trait analysis); CRC cis rs4665809 0.941 rs1470096 chr2:26311482 T/C cg25036284 chr2:26402008 FAM59B -0.47 -5.81 -0.3 1.5e-8 Gut microbiome composition (summer); CRC cis rs11719291 0.833 rs11713694 chr3:48833615 G/T cg07636037 chr3:49044803 WDR6 -0.82 -6.75 -0.35 6.8e-11 Cognitive function; CRC cis rs11711311 0.955 rs12630833 chr3:113390883 G/T cg15478005 chr3:113465772 ATP6V1A;NAA50 0.47 6.26 0.33 1.19e-9 IgG glycosylation; CRC cis rs3768617 0.706 rs9943067 chr1:182975102 C/T ch.1.3577855R chr1:183094577 LAMC1 0.65 9.94 0.48 1.6e-20 Fuchs's corneal dystrophy; CRC cis rs853679 0.517 rs11552219 chr6:28126834 C/T cg06470822 chr6:28175283 NA 1.03 13.59 0.6 1.04e-33 Depression; CRC cis rs6502050 0.723 rs11650633 chr17:80083807 T/C cg25804541 chr17:80189381 SLC16A3 0.31 6.1 0.32 3.05e-9 Life satisfaction; CRC cis rs2404602 0.583 rs12438741 chr15:76542114 C/A cg23625390 chr15:77176239 SCAPER 0.41 5.9 0.31 9.18e-9 Blood metabolite levels; CRC cis rs7916697 0.540 rs4551651 chr10:70024529 A/G cg06988349 chr10:69991859 ATOH7 0.38 7.1 0.36 7.84e-12 Optic disc area; CRC cis rs9911578 1.000 rs4372750 chr17:57013803 A/C cg05425664 chr17:57184151 TRIM37 0.5 7.91 0.4 3.91e-14 Intelligence (multi-trait analysis); CRC cis rs10256972 0.758 rs7799391 chr7:1082566 C/G cg04025307 chr7:1156635 C7orf50 0.53 8.15 0.41 7.66e-15 Longevity;Endometriosis; CRC trans rs2413583 0.591 rs12483879 chr22:39719148 C/G cg09612413 chr10:12085555 UPF2 -0.55 -6.06 -0.32 3.77e-9 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; CRC trans rs7615952 0.546 rs4428131 chr3:125346479 C/T cg02560186 chr11:3602584 NA -0.56 -6.92 -0.36 2.39e-11 Blood pressure (smoking interaction); CRC cis rs755249 0.567 rs67020650 chr1:39668015 T/C cg18385671 chr1:39797026 MACF1 -0.41 -5.93 -0.31 7.46e-9 Peripheral arterial disease (traffic-related air pollution interaction); CRC trans rs4650994 0.507 rs56229230 chr1:178526563 G/A cg05059571 chr16:84539110 KIAA1609 -0.64 -8.85 -0.44 5.5e-17 HDL cholesterol levels;HDL cholesterol; CRC cis rs758324 0.947 rs10054618 chr5:131195002 C/T cg06307176 chr5:131281290 NA 0.42 6.09 0.32 3.08e-9 Alzheimer's disease in APOE e4- carriers; CRC cis rs877282 0.628 rs11253435 chr10:824169 T/C cg17470449 chr10:769945 NA 0.5 7.06 0.36 9.9e-12 Uric acid levels; CRC cis rs6088590 0.687 rs6088582 chr20:33286798 G/A cg24642439 chr20:33292090 TP53INP2 0.45 7.9 0.4 4.36e-14 Coronary artery disease; CRC cis rs28386778 0.897 rs2584608 chr17:61936710 A/G cg11494091 chr17:61959527 GH2 0.62 10.48 0.5 2.23e-22 Prudent dietary pattern; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg01772115 chr1:90460555 ZNF326;LOC492303 0.46 7.51 0.38 5.56e-13 Liver disease severity in Alagille syndrome; CRC trans rs6788895 0.661 rs1533711 chr3:150469996 C/T cg12790874 chr13:100310405 CLYBL 0.61 6.3 0.33 9.58e-10 Breast cancer; CRC trans rs10504229 0.953 rs57131327 chr8:58171895 T/C cg04077850 chr5:125800366 GRAMD3 0.37 6.27 0.33 1.15e-9 Developmental language disorder (linguistic errors); CRC cis rs6502050 0.799 rs6502089 chr17:80169523 G/A cg25804541 chr17:80189381 SLC16A3 -0.29 -5.62 -0.3 4.11e-8 Life satisfaction; CRC cis rs9916302 0.904 rs587343 chr17:37440603 C/T cg00129232 chr17:37814104 STARD3 0.54 7.84 0.4 6.5e-14 Glomerular filtration rate (creatinine); CRC trans rs1456896 0.835 rs921914 chr7:50310728 T/G cg02134594 chr1:3632713 TP73 0.38 6.27 0.33 1.11e-9 Inflammatory bowel disease;Crohn's disease; CRC cis rs644799 0.932 rs480079 chr11:95643777 A/T cg03916912 chr11:95522834 CEP57;FAM76B -0.88 -15.78 -0.66 3.79e-42 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs8177253 0.829 rs6794945 chr3:133518463 A/G cg11941060 chr3:133502564 NA 0.65 10.76 0.51 2.5e-23 Iron status biomarkers; CRC cis rs4478137 0.931 rs12509756 chr4:164237464 A/T cg06758707 chr4:164254230 NPY1R 0.39 5.95 0.31 6.76e-9 Subjective well-being (multi-trait analysis);Subjective well-being; CRC cis rs13217239 0.646 rs9393789 chr6:27067028 G/T cg12292205 chr6:26970375 C6orf41 -0.53 -8.69 -0.43 1.75e-16 Schizophrenia; CRC cis rs9914988 0.725 rs66531973 chr17:27125993 G/T cg20469991 chr17:27169893 C17orf63 -0.6 -7.26 -0.37 2.78e-12 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs4268898 0.662 rs72793967 chr2:24422902 C/T cg06627628 chr2:24431161 ITSN2 -0.85 -11.72 -0.54 9.36e-27 Asthma; CRC cis rs9322193 0.683 rs113281309 chr6:150108425 T/G cg05861140 chr6:150128134 PCMT1 -0.43 -7.05 -0.36 1.03e-11 Lung cancer; CRC cis rs7208859 0.623 rs8075163 chr17:29106310 A/G cg01831904 chr17:28903510 LRRC37B2 -0.63 -6.45 -0.33 4.07e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC trans rs9291683 0.546 rs4529049 chr4:10045389 C/T cg26043149 chr18:55253948 FECH 0.49 7.42 0.38 9.93e-13 Bone mineral density; CRC cis rs62408225 0.722 rs1319433 chr6:90921988 G/A cg06866423 chr6:90926672 BACH2 0.67 12.55 0.57 8.4000000000000007e-30 Eosinophil counts;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC cis rs2721195 0.549 rs2958492 chr8:145919126 C/T cg15857475 chr8:145742913 RECQL4;LRRC14 0.47 7.23 0.37 3.36e-12 Age at first birth; CRC cis rs4713118 0.868 rs760587 chr6:27740300 C/A cg02683197 chr6:28174875 NA 0.69 7.44 0.38 8.81e-13 Parkinson's disease; CRC cis rs208346 1.000 rs208346 chr7:2799686 G/T cg23627948 chr7:2760692 NA 0.3 5.65 0.3 3.51e-8 Loneliness (linear analysis); CRC cis rs10504229 1.000 rs66672857 chr8:58179817 G/C cg24829409 chr8:58192753 C8orf71 -0.68 -11.34 -0.53 2.27e-25 Developmental language disorder (linguistic errors); CRC cis rs4728302 0.869 rs10155909 chr7:133593036 A/G cg10665199 chr7:133106180 EXOC4 0.39 5.84 0.31 1.25e-8 Intelligence;Intelligence (multi-trait analysis); CRC cis rs11577318 0.853 rs4333841 chr1:26631927 T/C cg00852783 chr1:26633632 UBXN11 0.47 6.83 0.35 4.2e-11 Granulocyte percentage of myeloid white cells; CRC cis rs847577 0.588 rs6946915 chr7:97711340 C/G cg21770322 chr7:97807741 LMTK2 0.82 18.29 0.71 4.59e-52 Breast cancer; CRC cis rs7149337 0.805 rs2999357 chr14:51606001 C/G cg18683604 chr14:51561293 TRIM9 0.29 6.0 0.31 5.11e-9 Cancer; CRC cis rs2404602 0.692 rs34478400 chr15:76923510 C/T cg23625390 chr15:77176239 SCAPER 0.47 6.9 0.36 2.72e-11 Blood metabolite levels; CRC cis rs13108904 0.934 rs13149952 chr4:1308437 C/G cg00684032 chr4:1343700 KIAA1530 0.45 6.52 0.34 2.7e-10 Obesity-related traits; CRC cis rs501120 0.584 rs673354 chr10:44733816 C/A cg09554077 chr10:44749378 NA 0.64 7.06 0.36 9.84e-12 Coronary artery disease;Coronary heart disease; CRC cis rs7726839 0.540 rs4957081 chr5:646418 G/C cg09021430 chr5:549028 NA -0.72 -8.15 -0.41 7.69e-15 Obesity-related traits; CRC cis rs7618915 0.524 rs12488461 chr3:52698417 T/C cg10802521 chr3:52805072 NEK4 -0.58 -8.85 -0.44 5.34e-17 Bipolar disorder; CRC cis rs780096 0.506 rs1262430 chr2:27673798 T/C cg24768116 chr2:27665128 KRTCAP3 -0.36 -8.28 -0.42 3.04e-15 Total body bone mineral density; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg05585758 chr2:43037627 NA 0.4 5.97 0.31 6.21e-9 Intelligence (multi-trait analysis); CRC cis rs853679 0.542 rs2295594 chr6:28053097 G/A cg12273811 chr6:28175739 NA 0.71 9.07 0.45 1.08e-17 Depression; CRC cis rs2070488 0.804 rs13092164 chr3:38458533 G/A cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.79 13.36 0.59 7.69e-33 Electrocardiographic conduction measures; CRC cis rs344364 0.511 rs337284 chr16:1954799 A/C cg03013636 chr16:1946785 NA 0.53 6.56 0.34 2.03e-10 Glomerular filtration rate in chronic kidney disease; CRC cis rs60843830 1.000 rs3828165 chr2:220889 G/A cg00108164 chr2:264199 ACP1;SH3YL1 0.63 9.68 0.47 1.13e-19 Spherical equivalent (joint analysis main effects and education interaction); CRC cis rs4713118 0.621 rs4713133 chr6:28034041 T/C cg18032046 chr6:28092343 ZSCAN16 -0.47 -5.6 -0.3 4.53e-8 Parkinson's disease; CRC cis rs55665837 1.000 rs12792120 chr11:14469443 G/T cg19336497 chr11:14380999 RRAS2 -0.38 -6.38 -0.33 6.11e-10 Vitamin D levels; CRC cis rs9322193 0.884 rs9688794 chr6:149953257 C/T cg00933542 chr6:150070202 PCMT1 0.29 5.97 0.31 6.09e-9 Lung cancer; CRC cis rs6089584 0.816 rs6061411 chr20:60634716 C/A cg23463467 chr20:60627584 TAF4 0.36 6.37 0.33 6.21e-10 Body mass index; CRC cis rs8177253 0.965 rs4854760 chr3:133498741 C/T cg11941060 chr3:133502564 NA 0.55 9.41 0.46 8.65e-19 Iron status biomarkers; CRC cis rs3772130 0.583 rs6767409 chr3:121564989 G/A cg20356878 chr3:121714668 ILDR1 0.37 6.1 0.32 2.91e-9 Cognitive performance; CRC cis rs7618915 0.571 rs7623199 chr3:52605974 C/T cg10802521 chr3:52805072 NEK4 -0.58 -9.01 -0.44 1.68e-17 Bipolar disorder; CRC trans rs7824557 0.603 rs2246606 chr8:11219334 G/A cg06636001 chr8:8085503 FLJ10661 0.43 6.18 0.32 1.89e-9 Retinal vascular caliber; CRC cis rs1552244 0.882 rs13063929 chr3:10010308 T/C cg02579736 chr3:10068473 FANCD2;CIDECP 0.96 12.39 0.56 3.27e-29 Alzheimer's disease; CRC cis rs8072100 0.967 rs11871606 chr17:45732774 G/T cg25173405 chr17:45401733 C17orf57 0.43 6.87 0.35 3.17e-11 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs11190604 1.000 rs2489035 chr10:102319395 C/T cg16342193 chr10:102329863 NA -0.34 -5.79 -0.3 1.67e-8 Palmitoleic acid (16:1n-7) levels; CRC cis rs9583531 0.657 rs9521915 chr13:111384528 C/T cg24331049 chr13:111365604 ING1 0.51 6.78 0.35 5.48e-11 Coronary artery disease; CRC cis rs10992471 0.603 rs10761160 chr9:95208701 A/T cg14631576 chr9:95140430 CENPP -0.4 -7.13 -0.37 6.48e-12 Visceral adipose tissue/subcutaneous adipose tissue ratio; CRC cis rs12142240 0.698 rs6684274 chr1:46810842 A/G cg00530320 chr1:46809349 NSUN4 -0.59 -8.2 -0.41 5.44e-15 Menopause (age at onset); CRC cis rs3812762 0.871 rs2173999 chr11:8778077 G/A cg00186954 chr11:8933980 ST5;C11orf17 0.37 6.09 0.32 3.15e-9 Hypospadias; CRC trans rs7267979 0.966 rs4815425 chr20:25398876 G/C cg17903999 chr18:56338584 MALT1 0.41 6.91 0.36 2.56e-11 Liver enzyme levels (alkaline phosphatase); CRC trans rs916888 0.821 rs199505 chr17:44859410 A/G cg22433210 chr17:43662623 NA -0.82 -9.07 -0.45 1.11e-17 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs1862618 0.853 rs832565 chr5:56150803 T/G cg22800045 chr5:56110881 MAP3K1 0.58 6.39 0.33 5.62e-10 Initial pursuit acceleration; CRC cis rs6424115 0.830 rs1106 chr1:24200772 C/G cg15997130 chr1:24165203 NA 0.73 10.74 0.51 2.79e-23 Immature fraction of reticulocytes; CRC cis rs933688 1.000 rs1035477 chr5:90743325 T/C cg26981201 chr5:90679533 LOC100129716;ARRDC3 0.98 15.01 0.64 3.59e-39 Smoking behavior; CRC cis rs1552244 1.000 rs67852463 chr3:10157205 G/C cg16606324 chr3:10149918 C3orf24 0.75 9.83 0.48 3.62e-20 Alzheimer's disease; CRC cis rs13191362 0.935 rs13212137 chr6:163010261 A/G cg06582575 chr6:163149167 PACRG;PARK2 0.75 10.24 0.49 1.58e-21 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs6089584 0.586 rs1079755 chr20:60615262 G/A cg23463467 chr20:60627584 TAF4 0.39 7.06 0.36 9.79e-12 Body mass index; CRC cis rs2976388 0.609 rs2572904 chr8:143792193 A/C cg12516270 chr8:143859308 LYNX1 0.44 7.79 0.39 8.89e-14 Urinary tract infection frequency; CRC cis rs910187 0.678 rs3818006 chr20:45816328 A/G cg27589058 chr20:45804311 EYA2 -0.39 -7.52 -0.38 5.4e-13 Migraine; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg11866396 chr17:5322940 RPAIN;NUP88 0.41 6.69 0.35 9.33e-11 Liver disease severity in Alagille syndrome; CRC cis rs9322193 0.884 rs7450246 chr6:150023653 C/T cg00933542 chr6:150070202 PCMT1 0.32 6.57 0.34 1.94e-10 Lung cancer; CRC cis rs1550582 1.000 rs76091740 chr8:135514419 C/T cg17885191 chr8:135476712 NA 0.72 8.27 0.41 3.42e-15 Educational attainment; CRC trans rs10504229 1.000 rs113379801 chr8:58173686 C/G cg04077850 chr5:125800366 GRAMD3 0.36 6.13 0.32 2.47e-9 Developmental language disorder (linguistic errors); CRC trans rs11343 0.675 rs7359333 chr16:19262344 A/T cg23438505 chr17:78489298 NA -0.45 -6.3 -0.33 9.8e-10 Parkinson's disease; CRC cis rs868943 0.714 rs4415182 chr6:116382811 G/A cg18764771 chr6:116381957 FRK 0.26 6.36 0.33 6.92e-10 Total cholesterol levels; CRC cis rs262150 0.659 rs2657340 chr7:158796968 C/T cg19418458 chr7:158789849 NA 0.49 8.45 0.42 9.51e-16 Facial morphology (factor 20); CRC cis rs4237845 0.537 rs10877031 chr12:58266695 A/G cg00677455 chr12:58241039 CTDSP2 0.77 11.13 0.52 1.25e-24 Intelligence (multi-trait analysis); CRC trans rs7618501 0.933 rs1128535 chr3:49866392 C/T cg21665057 chr3:196295764 WDR53;FBXO45 0.86 15.99 0.66 5.77e-43 Intelligence (multi-trait analysis); CRC cis rs4953076 0.573 rs6738023 chr2:44405931 T/C cg04920474 chr2:44395004 PPM1B 0.57 7.65 0.39 2.17e-13 Height; CRC cis rs17384381 1.000 rs17388521 chr1:85897904 A/G cg16011679 chr1:85725395 C1orf52 -0.66 -7.01 -0.36 1.4e-11 Lobe attachment (rater-scored or self-reported); CRC cis rs10870270 0.912 rs7079991 chr10:133736130 A/G cg17892150 chr10:133769511 PPP2R2D -0.72 -10.94 -0.52 5.62e-24 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; CRC cis rs2455601 0.882 rs11042115 chr11:8926679 A/C cg21881798 chr11:8931708 C11orf17;ST5 -0.54 -6.08 -0.32 3.3e-9 Schizophrenia; CRC cis rs853679 0.517 rs16893666 chr6:28054707 C/T cg21251018 chr6:28226885 NKAPL -0.48 -6.38 -0.33 6.16e-10 Depression; CRC cis rs9517320 0.534 rs61969451 chr13:99167654 A/T cg20487152 chr13:99095054 FARP1 -0.44 -6.43 -0.33 4.54e-10 Longevity; CRC cis rs10504229 1.000 rs17217082 chr8:58180918 G/A cg24829409 chr8:58192753 C8orf71 -0.68 -11.34 -0.53 2.27e-25 Developmental language disorder (linguistic errors); CRC cis rs3815700 1.000 rs8109990 chr19:33095636 A/G cg02997394 chr19:33096574 ANKRD27 0.73 8.3 0.42 2.81e-15 Eosinophilic esophagitis; CRC cis rs7762018 0.770 rs3823466 chr6:170189926 C/T cg17545662 chr6:170176663 C6orf70 0.48 5.72 0.3 2.37e-8 Thiazide-induced adverse metabolic effects in hypertensive patients; CRC cis rs896854 0.654 rs896846 chr8:95972453 G/A cg23172400 chr8:95962367 TP53INP1 -0.48 -8.19 -0.41 5.98e-15 Type 2 diabetes; CRC cis rs12983728 0.732 rs34003091 chr19:58662254 T/C cg21294424 chr19:58662284 ZNF329 0.85 9.53 0.47 3.54e-19 Cholesterol, total; CRC cis rs2302190 0.882 rs8068135 chr17:56654210 A/C cg25885038 chr17:56607967 SEPT4 -0.51 -7.61 -0.39 2.96e-13 Vitamin D levels; CRC cis rs2073300 0.609 rs6137914 chr20:23358364 C/T cg12062639 chr20:23401060 NAPB 0.71 6.49 0.34 3.11e-10 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs2075371 0.863 rs2075370 chr7:133967812 A/G cg02659138 chr7:134003124 SLC35B4 0.35 6.13 0.32 2.48e-9 Mean platelet volume; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg00881440 chr7:2595255 C7orf27 0.48 7.7 0.39 1.5700000000000001e-13 Liver disease severity in Alagille syndrome; CRC cis rs910316 0.935 rs175448 chr14:75591071 G/A cg08847533 chr14:75593920 NEK9 -0.89 -16.42 -0.67 1.1e-44 Height; CRC trans rs11098499 0.954 rs10518328 chr4:120401779 G/A cg25214090 chr10:38739885 LOC399744 0.64 10.32 0.49 8.44e-22 Corneal astigmatism; CRC cis rs9435341 0.896 rs1730850 chr1:107597988 C/T cg15468180 chr1:107600409 PRMT6 -0.45 -6.73 -0.35 7.76e-11 Facial morphology (factor 21, depth of nasal alae); CRC cis rs7208859 0.614 rs28758251 chr17:29223312 A/T cg14008862 chr17:28927542 LRRC37B2 0.55 5.75 0.3 2.04e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs6662572 0.737 rs9429184 chr1:46524739 G/A cg03123370 chr1:45965343 CCDC163P;MMACHC 0.49 6.37 0.33 6.29e-10 Blood protein levels; CRC trans rs1814175 0.645 rs4625470 chr11:49983769 T/C cg15704280 chr7:45808275 SEPT13 -0.94 -16.88 -0.68 1.75e-46 Height; CRC cis rs28655083 1.000 rs28655083 chr16:77061214 C/G cg01753188 chr16:77233325 SYCE1L;MON1B -0.58 -8.09 -0.41 1.12e-14 Lobe attachment (rater-scored or self-reported); CRC cis rs4481887 0.893 rs4244186 chr1:248493319 A/G cg13385794 chr1:248469461 NA 0.38 6.56 0.34 2.08e-10 Common traits (Other); CRC cis rs6748734 1.000 rs4344931 chr2:241818527 A/C cg04034577 chr2:241836375 C2orf54 -0.42 -8.92 -0.44 3.42e-17 Urinary metabolites; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg01754155 chr3:98620518 DCBLD2 0.39 6.29 0.33 1.03e-9 Liver disease severity in Alagille syndrome; CRC cis rs9303401 0.614 rs3803753 chr17:56540110 G/A cg10487724 chr17:56770010 TEX14;RAD51C 0.77 9.53 0.47 3.55e-19 Cognitive test performance; CRC cis rs1881797 1.000 rs10925069 chr1:247681313 C/T cg05639522 chr1:247681581 NA -0.52 -8.74 -0.43 1.18e-16 Acute lymphoblastic leukemia (childhood); CRC trans rs9378357 0.702 rs4383859 chr6:3280241 C/G cg00226545 chr16:54320225 IRX3 0.76 6.2 0.32 1.72e-9 Obesity-related traits; CRC cis rs875971 0.895 rs4145009 chr7:65726615 T/C cg12463550 chr7:65579703 CRCP -0.51 -7.11 -0.37 7.14e-12 Aortic root size; CRC cis rs12545109 0.775 rs10093388 chr8:57318799 C/T cg09654669 chr8:57350985 NA -0.51 -8.22 -0.41 4.59e-15 Obesity-related traits; CRC cis rs10540 0.915 rs35389167 chr11:460765 A/G cg11503833 chr11:492997 NA 0.56 5.89 0.31 9.64e-9 Body mass index; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg20331612 chr10:3282311 NA 0.4 5.99 0.31 5.48e-9 Response to antipsychotic treatment; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg04402184 chr1:193028837 TROVE2;UCHL5 0.47 6.79 0.35 5.4e-11 Intelligence (multi-trait analysis); CRC cis rs7705042 0.828 rs6580224 chr5:141489306 A/G cg07392085 chr5:141489673 NDFIP1 0.46 7.2 0.37 4.04e-12 Asthma; CRC cis rs9818758 0.556 rs11716614 chr3:49017208 C/G cg01304814 chr3:48885189 PRKAR2A 0.86 6.24 0.33 1.32e-9 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; CRC trans rs11661542 0.967 rs11082043 chr18:20222985 C/G cg20497554 chr1:28908371 SNHG12;SNORA44;SNORA16A -0.45 -6.37 -0.33 6.26e-10 Intracranial aneurysm; CRC cis rs7914558 0.966 rs10883805 chr10:104708251 T/C cg04362960 chr10:104952993 NT5C2 0.61 9.23 0.45 3.48e-18 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs8105895 0.935 rs10420019 chr19:22251905 T/A cg02657401 chr19:22469223 NA -0.34 -5.65 -0.3 3.56e-8 Body mass index (change over time); CRC cis rs73206853 0.764 rs56123836 chr12:110999032 G/A cg12870014 chr12:110450643 ANKRD13A 0.81 9.34 0.46 1.45e-18 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC cis rs60871478 0.947 rs62432239 chr7:794576 C/T cg04727924 chr7:799746 HEATR2 -0.43 -6.41 -0.33 4.99e-10 Cerebrospinal P-tau181p levels; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg03500911 chr18:48556576 SMAD4 0.47 6.45 0.34 4.04e-10 Anxiety disorder; CRC cis rs35883536 1.000 rs12566507 chr1:101089679 T/A cg14515779 chr1:101123966 NA -0.43 -8.39 -0.42 1.49e-15 Monocyte count; CRC trans rs61931739 0.534 rs7310499 chr12:34212112 G/A cg26384229 chr12:38710491 ALG10B 0.54 6.87 0.35 3.29e-11 Morning vs. evening chronotype; CRC cis rs12024301 0.557 rs10911389 chr1:183616805 T/C cg11505048 chr1:183622726 RGL1;APOBEC4 0.81 6.86 0.35 3.41e-11 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs7071206 0.947 rs4979902 chr10:79399946 C/T cg07817648 chr10:79422355 NA 0.79 10.33 0.49 7.59e-22 Bone mineral density; CRC cis rs6120849 0.754 rs6087666 chr20:33640242 G/A cg08999081 chr20:33150536 PIGU 0.44 5.72 0.3 2.39e-8 Protein C levels; CRC cis rs2795502 0.564 rs11239826 chr10:43403097 T/C cg20628663 chr10:43360327 NA 0.55 6.21 0.32 1.59e-9 Blood protein levels; CRC trans rs12478296 0.792 rs6738361 chr2:243014257 C/T cg18288967 chr1:45987694 PRDX1 0.58 6.36 0.33 6.58e-10 Obesity-related traits; CRC cis rs13315871 0.929 rs11130627 chr3:58315749 G/A cg20936604 chr3:58311152 NA -0.76 -7.13 -0.37 6.48e-12 Cholesterol, total; CRC cis rs12143943 1.000 rs12143943 chr1:204572071 G/A cg17419461 chr1:204415978 PIK3C2B 0.37 5.71 0.3 2.59e-8 Cognitive performance; CRC cis rs9359856 0.623 rs1179907 chr6:90324849 A/G cg13799429 chr6:90582589 CASP8AP2 -0.65 -9.44 -0.46 7.16e-19 Bipolar disorder; CRC cis rs4862750 0.872 rs13143414 chr4:187878213 G/A cg10295955 chr4:187884368 NA -1.03 -26.55 -0.83 8.54e-84 Lobe attachment (rater-scored or self-reported); CRC cis rs7301826 0.651 rs4759521 chr12:131297313 C/T cg11011512 chr12:131303247 STX2 0.37 5.62 0.3 4.1e-8 Plasma plasminogen activator levels; CRC cis rs11608355 0.515 rs7955932 chr12:109941303 G/A cg05360138 chr12:110035743 NA 0.76 8.52 0.43 5.88e-16 Neuroticism; CRC cis rs910316 0.763 rs175435 chr14:75612025 A/G cg11812906 chr14:75593930 NEK9 0.56 8.64 0.43 2.53e-16 Height; CRC cis rs6502050 0.799 rs8069827 chr17:80089168 C/T cg02741985 chr17:80059408 CCDC57 0.43 7.13 0.37 6.48e-12 Life satisfaction; CRC cis rs6502050 0.835 rs4641801 chr17:80154021 G/A cg22110888 chr17:80059540 CCDC57 0.39 6.2 0.32 1.71e-9 Life satisfaction; CRC cis rs9611565 0.765 rs132914 chr22:41805749 T/C cg06481639 chr22:41940642 POLR3H 0.51 5.89 0.31 9.38e-9 Vitiligo; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg22537964 chr8:54755419 ATP6V1H 0.41 6.04 0.32 4.15e-9 Intelligence (multi-trait analysis); CRC cis rs6815814 0.950 rs5743580 chr4:38804405 C/T cg06935464 chr4:38784597 TLR10 0.57 5.97 0.31 6.19e-9 Breast cancer; CRC cis rs6502050 0.699 rs9901808 chr17:80107814 C/T cg25804541 chr17:80189381 SLC16A3 -0.3 -5.9 -0.31 9.28e-9 Life satisfaction; CRC cis rs1552244 1.000 rs61052895 chr3:10147516 G/A cg08888203 chr3:10149979 C3orf24 0.71 9.76 0.47 6.26e-20 Alzheimer's disease; CRC cis rs861020 0.630 rs656566 chr1:210006603 C/T cg09163369 chr1:210001066 C1orf107 0.4 5.75 0.3 2.08e-8 Orofacial clefts; CRC cis rs769267 0.930 rs2301784 chr19:19390749 G/A cg02546618 chr19:19431379 KIAA0892;SF4 0.46 6.3 0.33 9.51e-10 Tonsillectomy; CRC cis rs897984 0.806 rs9319588 chr16:30930983 C/T cg02466173 chr16:30829666 NA 0.66 9.94 0.48 1.6e-20 Dementia with Lewy bodies; CRC cis rs1018836 0.886 rs7817954 chr8:91535105 G/A cg16814680 chr8:91681699 NA -0.75 -12.1 -0.55 3.92e-28 Ejection fraction in Tripanosoma cruzi seropositivity; CRC cis rs965469 1.000 rs6051806 chr20:3350319 C/T cg25506879 chr20:3388711 C20orf194 -0.39 -5.63 -0.3 3.97e-8 IFN-related cytopenia; CRC cis rs9287719 0.674 rs12622551 chr2:10720443 G/A cg00105475 chr2:10696890 NA 0.45 7.06 0.36 9.97e-12 Prostate cancer; CRC cis rs834811 0.583 rs10954517 chr7:135871947 T/C cg01726295 chr7:135938950 NA 0.37 6.43 0.33 4.4e-10 Post-traumatic stress disorder; CRC cis rs4481887 0.741 rs4360554 chr1:248553206 C/T cg00666640 chr1:248458726 OR2T12 0.41 7.43 0.38 9.52e-13 Common traits (Other); CRC cis rs5769765 0.955 rs9616394 chr22:50314927 G/C cg22709217 chr22:50311962 ALG12;CRELD2 -1.09 -18.15 -0.71 1.75e-51 Schizophrenia; CRC trans rs1728785 0.901 rs11642189 chr16:68583990 G/A cg04657470 chr2:198365150 HSPE1;HSPD1 0.58 7.07 0.36 9.08e-12 Ulcerative colitis; CRC cis rs7572644 0.608 rs75429814 chr2:27961614 T/C cg27432699 chr2:27873401 GPN1 0.51 5.74 0.3 2.13e-8 Response to carboplatin and paclitaxel in ovarian cancer (Caspase 3/7 EC50); CRC cis rs7119 0.700 rs4886883 chr15:77888924 C/T cg27398640 chr15:77910606 LINGO1 -0.48 -8.88 -0.44 4.28e-17 Type 2 diabetes; CRC cis rs703842 1.000 rs10877015 chr12:58167788 A/G cg00677455 chr12:58241039 CTDSP2 0.68 9.3 0.46 1.98e-18 Multiple sclerosis; CRC cis rs787274 0.718 rs4979170 chr9:115626918 C/G cg13803584 chr9:115635662 SNX30 0.6 5.89 0.31 9.38e-9 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs734999 0.588 rs11585048 chr1:2534087 C/T cg18854424 chr1:2615690 NA 0.4 7.64 0.39 2.32e-13 Ulcerative colitis; CRC trans rs13046373 0.905 rs4816372 chr21:32077414 A/T cg22819135 chr5:41920822 C5orf51 -0.4 -6.02 -0.31 4.53e-9 HDL cholesterol; CRC cis rs4660306 1.000 rs7536557 chr1:45992114 T/C cg03123370 chr1:45965343 CCDC163P;MMACHC -0.53 -7.58 -0.39 3.46e-13 Homocysteine levels; CRC cis rs9303401 0.646 rs9892425 chr17:57241938 C/T cg10487724 chr17:56770010 TEX14;RAD51C 0.4 6.03 0.32 4.39e-9 Cognitive test performance; CRC cis rs2270875 1.000 rs78340057 chr8:132927607 T/G cg24184792 chr8:132919238 EFR3A -0.68 -6.92 -0.36 2.39e-11 Response to cholinesterase inhibitors in Alzheimer's disease; CRC trans rs4263408 0.934 rs9683743 chr4:39703194 A/C cg05655116 chr2:37899435 CDC42EP3 -0.42 -6.16 -0.32 2.14e-9 Plasma amyloid beta peptide concentrations (ABx-40); CRC cis rs561341 0.609 rs4795659 chr17:30187139 C/G cg13647721 chr17:30228624 UTP6 -0.63 -7.22 -0.37 3.53e-12 Hip circumference adjusted for BMI; CRC cis rs2762353 0.505 rs2096386 chr6:25787817 C/T cg17691542 chr6:26056736 HIST1H1C -0.49 -6.81 -0.35 4.74e-11 Blood metabolite levels; CRC cis rs977987 0.705 rs4888377 chr16:75325686 C/G cg03315344 chr16:75512273 CHST6 0.61 9.86 0.48 2.85e-20 Dupuytren's disease; CRC trans rs1005277 0.505 rs719569 chr10:38154415 T/G cg27523141 chr10:43048294 ZNF37B -0.45 -6.59 -0.34 1.7e-10 Extrinsic epigenetic age acceleration; CRC cis rs1552244 0.882 rs113268531 chr3:10167069 A/G cg13047869 chr3:10149882 C3orf24 0.56 7.6 0.39 3.07e-13 Alzheimer's disease; CRC cis rs12410462 0.502 rs78101727 chr1:227732069 C/T cg23173402 chr1:227635558 NA 0.76 6.22 0.32 1.51e-9 Major depressive disorder; CRC trans rs7267979 1.000 rs6050617 chr20:25421648 C/T cg17903999 chr18:56338584 MALT1 -0.42 -6.98 -0.36 1.6e-11 Liver enzyme levels (alkaline phosphatase); CRC cis rs7617773 0.815 rs6793150 chr3:48351560 G/A cg11946769 chr3:48343235 NME6 0.73 9.79 0.47 4.96e-20 Coronary artery disease; CRC cis rs9549328 0.800 rs1317507 chr13:113631780 G/T cg20742385 chr13:113633654 MCF2L -0.69 -12.1 -0.55 4.02e-28 Systolic blood pressure; CRC cis rs9309711 0.922 rs11679058 chr2:3483813 C/G cg10845886 chr2:3471009 TTC15 -0.72 -11.66 -0.54 1.57e-26 Neurofibrillary tangles; CRC cis rs6761276 0.868 rs13386602 chr2:113834820 A/C cg24553058 chr2:113831203 IL1F10 0.4 6.44 0.33 4.26e-10 Protein quantitative trait loci; CRC cis rs4713118 0.586 rs6905522 chr6:28086479 A/C cg18032046 chr6:28092343 ZSCAN16 -0.52 -6.02 -0.31 4.76e-9 Parkinson's disease; CRC cis rs4969178 0.965 rs8071889 chr17:76398101 A/G cg20026190 chr17:76395443 PGS1 0.4 6.14 0.32 2.35e-9 HDL cholesterol levels; CRC cis rs904251 0.504 rs1757188 chr6:37483808 A/G cg25019722 chr6:37503610 NA -0.47 -8.79 -0.44 8.43e-17 Cognitive performance; CRC cis rs11792861 0.591 rs2282206 chr9:111746267 A/G cg14432460 chr9:111696404 IKBKAP;C9orf6 0.53 7.46 0.38 7.74e-13 Menarche (age at onset); CRC cis rs6570726 0.905 rs406799 chr6:145821837 G/C cg23711669 chr6:146136114 FBXO30 0.68 12.16 0.56 2.33e-28 Lobe attachment (rater-scored or self-reported); CRC cis rs10883723 0.773 rs7917402 chr10:104246690 C/T cg11453585 chr10:104263688 ACTR1A;SUFU 0.91 17.37 0.69 2.02e-48 Allergic disease (asthma, hay fever or eczema); CRC cis rs172166 0.543 rs1150691 chr6:28168033 A/G cg12273811 chr6:28175739 NA 0.46 6.63 0.34 1.41e-10 Cardiac Troponin-T levels; CRC trans rs9929218 0.953 rs9939049 chr16:68812301 A/T cg04657470 chr2:198365150 HSPE1;HSPD1 -0.82 -11.5 -0.54 5.89e-26 Colorectal cancer; CRC cis rs919433 0.680 rs4685 chr2:198257795 C/T cg10820045 chr2:198174542 NA -0.39 -6.77 -0.35 5.97e-11 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg13150400 chr6:135819157 C6orf217;AHI1 0.39 6.42 0.33 4.77e-10 Liver disease severity in Alagille syndrome; CRC cis rs10504073 0.584 rs11778863 chr8:49954893 C/T cg00325661 chr8:49890786 NA 0.59 10.66 0.51 5.37e-23 Blood metabolite ratios; CRC cis rs2836974 0.931 rs13625 chr21:40669083 G/T cg17971929 chr21:40555470 PSMG1 0.81 11.47 0.53 7.41e-26 Cognitive function; CRC cis rs4713118 0.824 rs9366702 chr6:27734470 T/C cg12172441 chr6:28176163 NA 0.54 7.02 0.36 1.31e-11 Parkinson's disease; CRC cis rs7615952 0.641 rs7640158 chr3:125808011 G/A cg15145296 chr3:125709740 NA -0.57 -6.72 -0.35 8.16e-11 Blood pressure (smoking interaction); CRC trans rs7395662 0.591 rs10838968 chr11:48595046 A/G cg03929089 chr4:120376271 NA -0.47 -6.62 -0.34 1.44e-10 HDL cholesterol; CRC cis rs11677370 0.561 rs13015012 chr2:3821252 C/G cg17052675 chr2:3827356 NA 0.66 11.4 0.53 1.36e-25 Type 2 diabetes; CRC cis rs11105298 0.891 rs1008764 chr12:89887649 T/C cg08166232 chr12:89918718 WDR51B;GALNT4 -0.61 -7.71 -0.39 1.47e-13 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; CRC cis rs775227 0.574 rs13068107 chr3:113029530 A/C cg18753928 chr3:113234510 CCDC52 -0.53 -6.56 -0.34 2.07e-10 Dental caries; CRC cis rs5750830 0.649 rs4821894 chr22:39809820 G/C cg24399712 chr22:39784796 NA -0.46 -8.72 -0.43 1.45e-16 Intelligence (multi-trait analysis); CRC trans rs1814175 0.746 rs10839429 chr11:49906845 G/A cg21153622 chr11:89784906 NA -0.37 -5.99 -0.31 5.61e-9 Height; CRC cis rs4965006 1.000 rs4965006 chr12:132419533 A/G cg00588090 chr12:132412438 PUS1 -0.51 -6.42 -0.33 4.84e-10 Posterior cortical atrophy and Alzheimer's disease; CRC cis rs2949837 0.581 rs1543270 chr7:46006323 C/T cg21268650 chr7:45961089 IGFBP3 0.38 6.38 0.33 5.94e-10 Sitting height ratio; CRC cis rs6952808 0.782 rs4236271 chr7:1881369 C/T cg20295408 chr7:1910781 MAD1L1 -0.43 -6.43 -0.33 4.51e-10 Bipolar disorder and schizophrenia; CRC cis rs965469 0.744 rs6139093 chr20:3334838 A/G cg25506879 chr20:3388711 C20orf194 -0.37 -5.77 -0.3 1.84e-8 IFN-related cytopenia; CRC cis rs10504229 0.728 rs17804666 chr8:58154473 C/T cg22535103 chr8:58192502 C8orf71 -0.68 -8.37 -0.42 1.72e-15 Developmental language disorder (linguistic errors); CRC cis rs3750082 0.632 rs35165932 chr7:32926260 T/G cg05721444 chr7:32995514 FKBP9 0.52 6.65 0.34 1.22e-10 Glomerular filtration rate (creatinine); CRC cis rs17767392 0.681 rs7146169 chr14:71684656 C/T cg13720639 chr14:72061746 SIPA1L1 -0.52 -6.72 -0.35 7.83e-11 Mitral valve prolapse; CRC cis rs1129187 0.755 rs9471976 chr6:42920549 G/T cg09436375 chr6:42928200 GNMT -0.35 -6.59 -0.34 1.8e-10 Alzheimer's disease in APOE e4+ carriers; CRC trans rs7615952 0.932 rs13314869 chr3:125644669 G/A cg02560186 chr11:3602584 NA -0.46 -6.23 -0.32 1.42e-9 Blood pressure (smoking interaction); CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg05563107 chr19:50528575 VRK3;ZNF473 0.51 6.51 0.34 2.81e-10 Thyroid stimulating hormone; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg01337508 chr17:40540572 STAT3 0.48 6.92 0.36 2.42e-11 Response to antipsychotic treatment; CRC cis rs7843479 0.582 rs11779655 chr8:21794041 A/G cg16476235 chr8:21771668 DOK2 -0.36 -6.02 -0.31 4.76e-9 Mean corpuscular volume; CRC cis rs1728785 0.901 rs11075688 chr16:68655924 A/G cg02972257 chr16:68554789 NA 0.57 6.84 0.35 3.98e-11 Ulcerative colitis; CRC cis rs9467711 0.606 rs9358938 chr6:26387546 C/T cg14345882 chr6:26364793 BTN3A2 0.78 6.31 0.33 8.91e-10 Autism spectrum disorder or schizophrenia; CRC cis rs4631830 0.720 rs113082846 chr10:51502802 G/C cg20129853 chr10:51489980 NA -0.43 -7.21 -0.37 3.76e-12 Prostate-specific antigen levels; CRC cis rs72781680 0.611 rs72797818 chr2:24351107 G/A cg20701182 chr2:24300061 SF3B14 0.66 7.83 0.4 6.69e-14 Lymphocyte counts; CRC cis rs4363385 0.747 rs4314835 chr1:152984901 C/T cg25856811 chr1:152973957 SPRR3 -0.25 -6.91 -0.36 2.54e-11 Inflammatory skin disease; CRC trans rs13090388 1 rs13090388 chr3:49391082 C/T cg21659725 chr3:3221576 CRBN -0.65 -8.93 -0.44 3.03e-17 Intelligence (multi-trait analysis);Educational attainment (years of education); CRC cis rs13191362 0.938 rs13213746 chr6:163167777 T/A cg06582575 chr6:163149167 PACRG;PARK2 0.78 10.66 0.51 5.39e-23 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs2050392 0.517 rs603072 chr10:30755778 C/T cg18806716 chr10:30721971 MAP3K8 0.56 8.02 0.4 1.88e-14 Inflammatory bowel disease; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg00704953 chr11:96123144 CCDC82;JRKL 0.42 6.32 0.33 8.73e-10 Liver disease severity in Alagille syndrome; CRC cis rs9322193 0.884 rs9383865 chr6:150173179 A/G cg05861140 chr6:150128134 PCMT1 -0.43 -6.96 -0.36 1.87e-11 Lung cancer; CRC trans rs10838798 0.504 rs11039632 chr11:48297280 C/T cg15704280 chr7:45808275 SEPT13 -0.48 -6.77 -0.35 5.89e-11 Height; CRC cis rs8072100 0.817 rs7213086 chr17:45752310 C/G cg25173405 chr17:45401733 C17orf57 -0.39 -5.99 -0.31 5.58e-9 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs2180341 0.814 rs9321085 chr6:127735361 T/C cg27446573 chr6:127587934 RNF146 0.69 9.42 0.46 8.11e-19 Breast cancer; CRC cis rs875971 0.660 rs7807930 chr7:66087165 C/T cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.44 -6.53 -0.34 2.43e-10 Aortic root size; CRC cis rs7927771 0.931 rs4752801 chr11:47907641 A/G cg20307385 chr11:47447363 PSMC3 -0.45 -6.25 -0.33 1.3e-9 Subjective well-being; CRC cis rs9300255 0.770 rs28683528 chr12:123845351 C/T cg00376283 chr12:123451042 ABCB9 -0.55 -7.21 -0.37 3.84e-12 Neutrophil percentage of white cells; CRC trans rs7615952 0.599 rs1875683 chr3:125732481 C/G cg07211511 chr3:129823064 LOC729375 -0.78 -10.81 -0.51 1.6e-23 Blood pressure (smoking interaction); CRC cis rs7618915 0.571 rs6805539 chr3:52609710 T/A cg18099408 chr3:52552593 STAB1 -0.44 -7.35 -0.38 1.62e-12 Bipolar disorder; CRC cis rs12762955 0.529 rs2387213 chr10:1051420 C/T cg20503657 chr10:835505 NA 0.49 6.68 0.35 1.02e-10 Response to angiotensin II receptor blocker therapy; CRC cis rs72717009 0.825 rs9427399 chr1:161476533 T/C cg10431340 chr1:161279108 MPZ -0.53 -6.98 -0.36 1.59e-11 Rheumatoid arthritis; CRC cis rs4713118 0.513 rs149878 chr6:27878738 T/G cg25164649 chr6:28176230 NA 0.65 9.43 0.46 7.83e-19 Parkinson's disease; CRC cis rs10423674 0.526 rs11668545 chr19:18829529 C/T cg12034943 chr19:18811790 CRTC1 -0.44 -5.71 -0.3 2.49e-8 Menarche (age at onset); CRC trans rs208515 0.556 rs12214562 chr6:66681011 T/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.94 11.9 0.55 2.04e-27 Exhaled nitric oxide levels; CRC cis rs3768617 0.510 rs1886499 chr1:183095024 C/T ch.1.3577855R chr1:183094577 LAMC1 0.89 15.86 0.66 1.84e-42 Fuchs's corneal dystrophy; CRC cis rs6582630 0.593 rs12816835 chr12:38533304 C/T cg26384229 chr12:38710491 ALG10B -0.53 -7.75 -0.39 1.15e-13 Drug-induced liver injury (flucloxacillin); CRC cis rs9534288 0.700 rs9316178 chr13:46570449 A/G cg15192986 chr13:46630673 CPB2 -0.68 -9.9 -0.48 2.1e-20 Blood protein levels; CRC trans rs916888 0.610 rs199536 chr17:44820425 T/C cg01341218 chr17:43662625 NA -0.59 -7.56 -0.38 4.03e-13 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs56283067 0.847 rs12215181 chr6:44736076 C/T cg18551225 chr6:44695536 NA -0.41 -5.8 -0.3 1.53e-8 Total body bone mineral density; CRC cis rs12190007 0.547 rs3006217 chr6:169862878 A/G cg15038512 chr6:170123185 PHF10 -0.37 -5.76 -0.3 1.9e-8 Obesity-related traits; CRC cis rs10504229 1.000 rs59071610 chr8:58186301 A/C cg24829409 chr8:58192753 C8orf71 -0.68 -11.21 -0.53 6.46e-25 Developmental language disorder (linguistic errors); CRC cis rs35306767 0.903 rs11253493 chr10:936931 T/C cg26597838 chr10:835615 NA 0.95 11.45 0.53 8.78e-26 Eosinophil percentage of granulocytes; CRC cis rs6912958 0.516 rs242278 chr6:88047059 C/T cg12350822 chr6:88032061 C6orf162;GJB7 0.46 9.53 0.47 3.62e-19 Monocyte percentage of white cells; CRC cis rs2797160 0.967 rs1954360 chr6:126001064 A/G cg05901451 chr6:126070800 HEY2 -0.4 -6.25 -0.33 1.26e-9 Endometrial cancer; CRC cis rs589448 0.967 rs634512 chr12:69754012 C/T cg20891283 chr12:69753455 YEATS4 0.99 21.43 0.76 2.12e-64 Cerebrospinal fluid biomarker levels; CRC cis rs514406 0.505 rs856721 chr1:53162156 C/A cg25767906 chr1:53392781 SCP2 -0.39 -5.91 -0.31 8.37e-9 Monocyte count; CRC trans rs6951245 1.000 rs78628466 chr7:1068453 G/C cg13565492 chr6:43139072 SRF -0.71 -7.31 -0.37 2.04e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs7119 0.700 rs57471224 chr15:77888169 A/G cg27398640 chr15:77910606 LINGO1 0.42 8.03 0.4 1.7e-14 Type 2 diabetes; CRC cis rs2562152 0.654 rs216600 chr16:110165 T/C cg02949481 chr16:131562 MPG 0.6 6.77 0.35 5.85e-11 Glioblastoma; CRC cis rs7274811 0.595 rs13045068 chr20:32133484 G/C cg03904042 chr20:32255491 NECAB3;C20orf134 -0.46 -6.26 -0.33 1.23e-9 Height; CRC cis rs7772486 0.686 rs2142983 chr6:146069701 G/C cg05347473 chr6:146136440 FBXO30 -0.37 -5.66 -0.3 3.25e-8 Lobe attachment (rater-scored or self-reported); CRC cis rs10782582 0.593 rs11163904 chr1:76121208 A/G cg10523679 chr1:76189770 ACADM 0.4 5.64 0.3 3.62e-8 Daytime sleep phenotypes; CRC cis rs2204008 0.837 rs4312131 chr12:38181087 G/T cg13010199 chr12:38710504 ALG10B 0.48 6.07 0.32 3.57e-9 Bladder cancer; CRC cis rs3750082 0.780 rs9638884 chr7:32913612 T/C cg05721444 chr7:32995514 FKBP9 0.51 7.87 0.4 5.33e-14 Glomerular filtration rate (creatinine); CRC cis rs780096 0.587 rs10205219 chr2:27568565 T/C cg17158414 chr2:27665306 KRTCAP3 -0.27 -5.76 -0.3 1.93e-8 Total body bone mineral density; CRC cis rs1129187 0.755 rs9471985 chr6:42941324 T/C cg02353165 chr6:42928485 GNMT 0.71 12.08 0.55 4.8e-28 Alzheimer's disease in APOE e4+ carriers; CRC cis rs1218582 0.741 rs11264283 chr1:154869552 A/G cg06221963 chr1:154839813 KCNN3 -0.77 -15.62 -0.65 1.57e-41 Prostate cancer; CRC cis rs1215050 0.755 rs6851840 chr4:98776366 A/G cg05340658 chr4:99064831 C4orf37 0.47 6.96 0.36 1.84e-11 Waist-to-hip ratio adjusted for body mass index; CRC cis rs7666738 0.791 rs7684521 chr4:99071219 A/G cg17366294 chr4:99064904 C4orf37 0.43 7.31 0.37 2.11e-12 Colonoscopy-negative controls vs population controls; CRC cis rs72781680 0.611 rs55788848 chr2:24268721 C/T cg20701182 chr2:24300061 SF3B14 0.59 6.69 0.35 9.34e-11 Lymphocyte counts; CRC cis rs902774 0.530 rs11834907 chr12:53350985 C/T cg25025879 chr12:53359317 NA -0.84 -7.95 -0.4 2.97e-14 Prostate cancer; CRC cis rs10450586 0.863 rs7115157 chr11:27301586 G/A cg10370305 chr11:27303972 NA 0.37 6.08 0.32 3.41e-9 Total body bone mineral density; CRC cis rs1448094 0.512 rs7953318 chr12:86245929 G/A cg19622623 chr12:86230825 RASSF9 -0.41 -6.76 -0.35 6.45e-11 Major depressive disorder; CRC cis rs9788721 0.836 rs7181486 chr15:78741618 C/T cg18825076 chr15:78729989 IREB2 0.49 7.54 0.38 4.75e-13 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio;Emphysema imaging phenotypes;Emphysema distribution in smoking;Local histogram emphysema pattern;Post bronchodilator FEV1/FVC ratio in COPD; CRC cis rs13315871 1.000 rs9869576 chr3:58401262 G/A cg20936604 chr3:58311152 NA -0.75 -7.12 -0.37 6.99e-12 Cholesterol, total; CRC cis rs9325144 0.600 rs1825807 chr12:38737007 T/C cg13010199 chr12:38710504 ALG10B 0.43 6.24 0.33 1.37e-9 Morning vs. evening chronotype; CRC cis rs6961069 0.745 rs3212160 chr7:80273308 A/C cg04458919 chr7:80252533 CD36 0.36 6.29 0.33 1.04e-9 Platelet count; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg09993119 chr22:41601085 L3MBTL2 0.49 6.91 0.36 2.58e-11 Response to antipsychotic treatment; CRC cis rs11585357 0.947 rs11585119 chr1:17605792 C/A cg08277548 chr1:17600880 PADI3 -0.92 -11.36 -0.53 1.94e-25 Hair shape; CRC cis rs1552244 0.882 rs13089863 chr3:10032259 G/T cg02579736 chr3:10068473 FANCD2;CIDECP -0.9 -10.91 -0.52 7.16e-24 Alzheimer's disease; CRC cis rs9905704 0.918 rs11656666 chr17:56929840 A/G cg12560992 chr17:57184187 TRIM37 0.53 7.35 0.38 1.57e-12 Testicular germ cell tumor; CRC cis rs916888 0.773 rs9896243 chr17:44826056 C/G cg15921436 chr17:44337874 NA 0.73 7.74 0.39 1.25e-13 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs10504229 0.610 rs6987118 chr8:58147851 G/T cg02290350 chr8:58132656 NA -0.53 -7.79 -0.39 9.03e-14 Developmental language disorder (linguistic errors); CRC cis rs2777491 1.000 rs11631770 chr15:41737059 T/C cg18705301 chr15:41695430 NDUFAF1 -0.73 -12.42 -0.56 2.69e-29 Ulcerative colitis; CRC cis rs1707322 0.682 rs10890335 chr1:46100394 G/C cg03146154 chr1:46216737 IPP 0.67 9.75 0.47 6.55e-20 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs10256972 0.552 rs2949192 chr7:1203841 C/T cg26608667 chr7:1196370 ZFAND2A 0.45 7.5 0.38 6.02e-13 Longevity;Endometriosis; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg26480543 chr19:55629279 PPP1R12C 0.46 6.64 0.34 1.28e-10 Response to antipsychotic treatment; CRC cis rs9584850 0.834 rs3783005 chr13:99111337 A/T cg20750642 chr13:99100586 FARP1 0.41 5.87 0.31 1.06e-8 Neuroticism; CRC trans rs8073060 0.586 rs9649 chr17:34050934 C/T cg19694781 chr19:47549865 TMEM160 1.08 14.73 0.63 4.38e-38 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; CRC cis rs12701220 0.948 rs12690826 chr7:1081618 A/G cg02733842 chr7:1102375 C7orf50 -0.71 -8.35 -0.42 1.93e-15 Bronchopulmonary dysplasia; CRC cis rs4822044 0.680 rs8138780 chr22:42097462 A/T cg06481639 chr22:41940642 POLR3H 0.52 5.9 0.31 9.19e-9 Cannabis dependence symptom count; CRC cis rs365302 1.000 rs433308 chr6:159619866 A/G cg14500486 chr6:159655392 FNDC1 -0.48 -6.98 -0.36 1.64e-11 Coronary heart disease; CRC cis rs6912958 0.712 rs9444526 chr6:88326402 A/G cg12350822 chr6:88032061 C6orf162;GJB7 -0.32 -6.01 -0.31 5.06e-9 Monocyte percentage of white cells; CRC cis rs4478858 0.746 rs7520439 chr1:31688721 G/C cg00250761 chr1:31883323 NA 0.31 5.82 0.31 1.4e-8 Alcohol dependence; CRC cis rs72945132 0.882 rs7123602 chr11:70181489 C/T cg00319359 chr11:70116639 PPFIA1 0.59 6.7 0.35 9.17e-11 Coronary artery disease; CRC cis rs344364 0.511 rs1742464 chr16:1947335 A/G cg03013636 chr16:1946785 NA -0.59 -7.34 -0.37 1.74e-12 Glomerular filtration rate in chronic kidney disease; CRC cis rs7680126 0.633 rs4697745 chr4:10305081 G/A cg00071950 chr4:10020882 SLC2A9 -0.45 -6.0 -0.31 5.29e-9 Urate levels in lean individuals;Urate levels in overweight individuals;Urate levels in obese individuals; CRC cis rs1348850 0.574 rs11691740 chr2:178445161 A/G cg27490568 chr2:178487706 NA -0.52 -6.7 -0.35 8.81e-11 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs875971 0.522 rs1968127 chr7:66056803 C/T cg18876405 chr7:65276391 NA -0.61 -11.09 -0.52 1.75e-24 Aortic root size; CRC trans rs9929218 0.911 rs4783686 chr16:68834156 C/G cg04657470 chr2:198365150 HSPE1;HSPD1 -0.8 -11.34 -0.53 2.17e-25 Colorectal cancer; CRC cis rs9527 0.590 rs7906754 chr10:104782557 T/C cg15744005 chr10:104629667 AS3MT -0.3 -5.96 -0.31 6.63e-9 Arsenic metabolism; CRC cis rs951366 0.617 rs9438393 chr1:205782718 A/G cg07157834 chr1:205819609 PM20D1 0.96 16.43 0.67 9.94e-45 Menarche (age at onset); CRC cis rs908922 0.676 rs6687126 chr1:152530894 T/G cg23254163 chr1:152506842 NA 0.45 9.15 0.45 6.31e-18 Hair morphology; CRC cis rs9322193 0.923 rs9322209 chr6:150012362 A/G cg00933542 chr6:150070202 PCMT1 0.3 6.19 0.32 1.8e-9 Lung cancer; CRC cis rs6545883 0.894 rs6760075 chr2:61612881 C/A cg15711740 chr2:61764176 XPO1 0.45 5.99 0.31 5.65e-9 Tuberculosis; CRC cis rs7215564 0.908 rs7501659 chr17:78662061 C/T cg09596252 chr17:78655493 RPTOR 0.56 6.03 0.32 4.39e-9 Myopia (pathological); CRC cis rs10504229 0.683 rs6999351 chr8:58127227 C/T cg21724239 chr8:58056113 NA 0.49 6.81 0.35 4.75e-11 Developmental language disorder (linguistic errors); CRC cis rs35123781 0.696 rs10067965 chr5:139071353 T/C cg10513866 chr5:139070639 NA 0.54 8.39 0.42 1.42e-15 Schizophrenia; CRC cis rs9302635 0.513 rs8061459 chr16:72156063 C/T cg23815491 chr16:72088622 HP 0.57 7.32 0.37 1.9e-12 Blood protein levels; CRC cis rs294883 0.739 rs1394236 chr6:159728679 T/G cg14500486 chr6:159655392 FNDC1 -0.34 -5.94 -0.31 7.37e-9 Coronary artery disease; CRC trans rs7647973 0.626 rs1463728 chr3:49647404 T/A cg21665057 chr3:196295764 WDR53;FBXO45 -0.65 -7.07 -0.36 9.12e-12 Menarche (age at onset); CRC cis rs17345786 0.798 rs9817043 chr3:101281852 A/G cg12386194 chr3:101231763 SENP7 0.48 6.68 0.35 1e-10 Colonoscopy-negative controls vs population controls; CRC cis rs7726839 0.574 rs12522955 chr5:639231 C/A cg14541582 chr5:601475 NA -0.36 -7.26 -0.37 2.87e-12 Obesity-related traits; CRC cis rs644799 0.710 rs522536 chr11:95528714 C/T cg25622487 chr11:95524042 FAM76B;CEP57 0.8 13.52 0.6 2.03e-33 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs394563 1.000 rs394563 chr6:149797014 T/G cg11245181 chr6:149772854 ZC3H12D -0.52 -8.69 -0.43 1.79e-16 Dupuytren's disease; CRC cis rs1552244 1.000 rs17032278 chr3:10077955 A/G cg10729496 chr3:10149963 C3orf24 0.55 7.11 0.37 7.07e-12 Alzheimer's disease; CRC cis rs1801251 1.000 rs283479 chr2:233648754 A/G cg25237894 chr2:233734115 C2orf82 0.57 9.23 0.45 3.51e-18 Coronary artery disease; CRC cis rs11122272 0.701 rs2790887 chr1:231523724 G/C cg06096015 chr1:231504339 EGLN1 0.4 5.98 0.31 5.78e-9 Hemoglobin concentration; CRC cis rs877282 0.853 rs11596346 chr10:756673 A/T cg17470449 chr10:769945 NA 0.61 7.96 0.4 2.78e-14 Uric acid levels; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg09469663 chr15:74908191 CLK3 0.4 6.27 0.33 1.12e-9 Liver disease severity in Alagille syndrome; CRC cis rs1552244 0.515 rs67626468 chr3:10161518 C/A cg02579736 chr3:10068473 FANCD2;CIDECP 1.01 11.61 0.54 2.33e-26 Alzheimer's disease; CRC cis rs7223966 0.921 rs2006123 chr17:61958669 G/T cg23903597 chr17:61704154 MAP3K3 -0.44 -6.05 -0.32 3.99e-9 Hip circumference adjusted for BMI;Body mass index; CRC trans rs9388451 0.874 rs3734634 chr6:126111800 G/A cg05039488 chr6:79577232 IRAK1BP1 -0.54 -8.24 -0.41 4.08e-15 Brugada syndrome; CRC cis rs9462846 0.691 rs9462853 chr6:42910666 T/C cg05552183 chr6:42928497 GNMT 0.47 6.58 0.34 1.83e-10 Blood protein levels; CRC cis rs1862618 0.713 rs832549 chr5:56183542 C/T cg20203395 chr5:56204925 C5orf35 -0.72 -8.29 -0.42 2.99e-15 Initial pursuit acceleration; CRC cis rs1760803 0.754 rs9803857 chr1:154191791 A/G cg26808167 chr1:154192205 UBAP2L;C1orf43 0.34 5.89 0.31 9.31e-9 Nicotine dependence; CRC cis rs7618915 0.571 rs12632381 chr3:52607685 G/A cg18099408 chr3:52552593 STAB1 -0.45 -7.39 -0.38 1.23e-12 Bipolar disorder; CRC cis rs10504229 0.815 rs17805008 chr8:58160185 G/T cg02290350 chr8:58132656 NA -0.51 -6.38 -0.33 5.84e-10 Developmental language disorder (linguistic errors); CRC cis rs9928842 0.823 rs8061356 chr16:75294232 G/A cg09066997 chr16:75300724 BCAR1 0.61 6.04 0.32 4.17e-9 Alcoholic chronic pancreatitis; CRC cis rs11212617 0.967 rs371406 chr11:108221482 A/G cg12106634 chr11:108092400 ATM;NPAT 0.39 5.67 0.3 3.21e-8 Response to metformin in type 2 diabetes (glycemic); CRC cis rs2953174 0.786 rs2953146 chr2:241515252 A/G cg07929629 chr2:241523174 NA -0.45 -5.69 -0.3 2.87e-8 Bipolar disorder; CRC cis rs873946 0.586 rs2001426 chr10:134563871 G/A cg26818010 chr10:134567672 INPP5A -0.71 -9.09 -0.45 9.28e-18 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CRC trans rs6561151 0.957 rs3764147 chr13:44457925 C/T cg12856521 chr11:46389249 DGKZ -0.6 -8.89 -0.44 4e-17 Crohn's disease; CRC cis rs4728142 0.604 rs13242262 chr7:128591364 A/T cg06630958 chr7:128577819 IRF5 -0.35 -5.79 -0.3 1.68e-8 Inflammatory bowel disease;Systemic lupus erythematosus;Ulcerative colitis; CRC cis rs11608355 0.545 rs12822974 chr12:109909154 G/T cg05360138 chr12:110035743 NA 0.78 8.75 0.43 1.15e-16 Neuroticism; CRC cis rs3741404 0.791 rs7112960 chr11:63907079 A/G cg18225595 chr11:63971243 STIP1 0.65 10.61 0.5 8.49e-23 Platelet count; CRC trans rs1656966 1.000 rs1656966 chr3:186466252 C/T cg23642001 chr8:67025419 NA 0.4 5.96 0.31 6.42e-9 Myopia (pathological); CRC cis rs7615952 0.641 rs4490307 chr3:125712676 T/G cg05084668 chr3:125655381 ALG1L -0.5 -7.95 -0.4 3.08e-14 Blood pressure (smoking interaction); CRC trans rs1814175 0.817 rs7927373 chr11:49957640 A/C cg11707556 chr5:10655725 ANKRD33B -0.42 -8.01 -0.4 2.02e-14 Height; CRC cis rs172166 0.769 rs149965 chr6:28018689 T/A cg18032046 chr6:28092343 ZSCAN16 -0.42 -5.75 -0.3 2e-8 Cardiac Troponin-T levels; CRC cis rs2797160 1.000 rs6933471 chr6:126017029 T/G cg05901451 chr6:126070800 HEY2 0.39 6.06 0.32 3.66e-9 Endometrial cancer; CRC cis rs1552244 1.000 rs3846177 chr3:10068572 G/T cg08888203 chr3:10149979 C3orf24 0.69 9.69 0.47 1.04e-19 Alzheimer's disease; CRC cis rs1799949 0.896 rs8176098 chr17:41268206 A/C cg25072359 chr17:41440525 NA 0.46 7.0 0.36 1.43e-11 Menopause (age at onset); CRC cis rs9462027 0.606 rs205258 chr6:34564243 T/C cg07306190 chr6:34760872 UHRF1BP1 -0.34 -5.99 -0.31 5.63e-9 Systemic lupus erythematosus; CRC cis rs12024301 0.557 rs10911416 chr1:183665120 T/G cg11505048 chr1:183622726 RGL1;APOBEC4 0.71 6.24 0.33 1.33e-9 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs6674176 0.628 rs3828146 chr1:44428715 C/T cg13606994 chr1:44402422 ARTN -0.34 -5.82 -0.31 1.4e-8 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Cognitive ability; CRC cis rs7727544 0.642 rs7705189 chr5:131623358 C/T cg22638593 chr5:131593259 PDLIM4 -0.32 -5.86 -0.31 1.15e-8 Blood metabolite levels; CRC trans rs264943 0.805 rs4851030 chr2:104160261 G/A cg08628431 chr5:14506972 TRIO 0.42 6.02 0.31 4.63e-9 HIV-1 viral setpoint; CRC cis rs8067545 0.611 rs2526477 chr17:20131193 A/G cg13482628 chr17:19912719 NA -0.47 -7.58 -0.39 3.64e-13 Schizophrenia; CRC trans rs4263408 0.934 rs9683743 chr4:39703194 A/C cg01490821 chr2:170684022 UBR3 -0.43 -6.32 -0.33 8.41e-10 Plasma amyloid beta peptide concentrations (ABx-40); CRC cis rs1451375 1.000 rs6949897 chr7:50621920 C/T cg14593290 chr7:50529359 DDC 0.55 7.7 0.39 1.65e-13 Malaria; CRC cis rs2228479 0.850 rs76075456 chr16:89834270 T/C cg06656553 chr16:89960601 TCF25 -0.7 -5.83 -0.31 1.34e-8 Skin colour saturation; CRC cis rs17152411 1.000 rs61873263 chr10:126589202 G/A cg07906193 chr10:126599966 NA 0.58 6.54 0.34 2.33e-10 Height; CRC cis rs4478858 0.735 rs12734617 chr1:31823446 G/T cg00250761 chr1:31883323 NA -0.41 -7.7 -0.39 1.61e-13 Alcohol dependence; CRC cis rs9443645 0.901 rs56057971 chr6:79607182 G/A cg11833968 chr6:79620685 NA -0.34 -5.97 -0.31 6.09e-9 Intelligence (multi-trait analysis); CRC cis rs2836974 0.932 rs8128734 chr21:40569511 G/A cg17971929 chr21:40555470 PSMG1 0.83 11.94 0.55 1.5e-27 Cognitive function; CRC cis rs1401999 0.628 rs1520195 chr3:183736882 G/A cg01324343 chr3:183735012 ABCC5 0.75 13.61 0.6 8.94e-34 Anterior chamber depth; CRC cis rs4689592 0.513 rs3857177 chr4:7066332 G/A cg26116260 chr4:7069785 GRPEL1 0.98 14.93 0.64 7.78e-39 Monocyte percentage of white cells; CRC cis rs12477438 0.798 rs2309524 chr2:99659510 A/T cg26064155 chr2:99771622 LIPT1;TSGA10 -0.78 -11.13 -0.52 1.21e-24 Chronic sinus infection; CRC cis rs6740322 0.901 rs2163228 chr2:43549246 C/T cg06169590 chr2:43455088 ZFP36L2;LOC100129726 -0.61 -7.05 -0.36 1.06e-11 Coronary artery disease; CRC cis rs8060686 0.641 rs76419201 chr16:68153553 G/A cg26727032 chr16:67993705 SLC12A4 -0.55 -6.3 -0.33 9.82e-10 HDL cholesterol;Metabolic syndrome; CRC cis rs1878931 0.582 rs27225 chr16:3428060 G/A cg26668626 chr16:3451006 ZNF174;ZNF434 -0.56 -6.98 -0.36 1.63e-11 Body mass index (adult); CRC trans rs1005277 0.540 rs2145487 chr10:38010077 A/G cg27523141 chr10:43048294 ZNF37B 0.45 6.46 0.34 3.73e-10 Extrinsic epigenetic age acceleration; CRC cis rs9910055 0.530 rs2269908 chr17:42294198 G/C cg10896456 chr17:42255109 ASB16;C17orf65 0.34 5.88 0.31 1.02e-8 Total body bone mineral density; CRC cis rs7811142 0.943 rs3900792 chr7:100004577 C/G cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.16 17.45 0.69 9.8e-49 Platelet count; CRC cis rs909002 0.800 rs968335 chr1:32085776 G/A cg01639898 chr1:32083012 HCRTR1 0.3 6.07 0.32 3.49e-9 Intelligence (multi-trait analysis); CRC trans rs6951245 0.529 rs10262070 chr7:1141738 C/T cg13565492 chr6:43139072 SRF -0.83 -10.57 -0.5 1.16e-22 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs514406 0.760 rs475969 chr1:53292607 T/A cg27535305 chr1:53392650 SCP2 -0.45 -8.17 -0.41 6.55e-15 Monocyte count; CRC cis rs644799 0.603 rs1255180 chr11:95472134 G/T cg25622487 chr11:95524042 FAM76B;CEP57 0.44 6.33 0.33 8.22e-10 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs2549003 1.000 rs2070731 chr5:131819798 T/C cg02551604 chr5:131831745 NA -0.58 -9.04 -0.45 1.41e-17 Asthma (sex interaction); CRC cis rs2952156 0.959 rs1495101 chr17:37832103 C/A cg00129232 chr17:37814104 STARD3 -0.69 -11.62 -0.54 2.25e-26 Asthma; CRC cis rs861020 0.527 rs614662 chr1:209962419 C/T cg22029157 chr1:209979665 IRF6 -0.52 -8.83 -0.44 6.32e-17 Orofacial clefts; CRC cis rs427941 0.668 rs201438 chr7:101735236 G/A cg06246474 chr7:101738831 CUX1 0.45 7.08 0.36 8.53e-12 Plasma omega-3 polyunsaturated fatty acid level (eicosapentaenoic acid); CRC trans rs4824093 0.535 rs9627797 chr22:50317569 G/A cg09872104 chr7:134855509 C7orf49 -0.75 -6.93 -0.36 2.25e-11 Amyotrophic lateral sclerosis (sporadic); CRC cis rs9322193 0.923 rs9372044 chr6:150102003 G/A cg00933542 chr6:150070202 PCMT1 0.28 5.63 0.3 3.86e-8 Lung cancer; CRC cis rs2463822 1.000 rs72921498 chr11:62113090 C/T cg06239285 chr11:62104954 ASRGL1 -0.95 -10.98 -0.52 4.14e-24 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs1129187 0.755 rs9462856 chr6:42926024 T/C cg09436375 chr6:42928200 GNMT -0.34 -6.24 -0.33 1.36e-9 Alzheimer's disease in APOE e4+ carriers; CRC cis rs7762018 0.556 rs78864023 chr6:170059755 T/A cg24289452 chr6:170231220 NA -0.78 -6.96 -0.36 1.86e-11 Thiazide-induced adverse metabolic effects in hypertensive patients; CRC cis rs13108904 0.870 rs4493483 chr4:1279916 G/A cg05665937 chr4:1216051 CTBP1 0.4 5.78 0.3 1.74e-8 Obesity-related traits; CRC cis rs9303401 0.659 rs9303399 chr17:56672309 C/T cg02118635 chr17:56770003 RAD51C;TEX14 0.77 9.39 0.46 1e-18 Cognitive test performance; CRC trans rs7937682 0.883 rs2212520 chr11:111462096 C/T cg18187862 chr3:45730750 SACM1L 0.43 6.14 0.32 2.38e-9 Primary sclerosing cholangitis; CRC cis rs7618501 1.000 rs34614773 chr3:49753003 T/G cg24308560 chr3:49941425 MST1R 0.45 7.16 0.37 5.47e-12 Intelligence (multi-trait analysis); CRC cis rs10927875 0.541 rs761759 chr1:16342350 A/T cg10494257 chr1:16342123 HSPB7 0.45 6.33 0.33 7.97e-10 Dilated cardiomyopathy; CRC cis rs12760731 0.622 rs12743256 chr1:178576505 T/C cg00404053 chr1:178313656 RASAL2 0.65 6.95 0.36 2.03e-11 Obesity-related traits; CRC trans rs66759488 0.739 rs10851451 chr15:47608991 A/G cg01708711 chr7:75959031 YWHAG -0.44 -6.01 -0.31 4.84e-9 Lung cancer; CRC cis rs6433857 0.594 rs34526919 chr2:181522678 T/A cg23363182 chr2:181467187 NA -0.47 -7.28 -0.37 2.42e-12 Body mass index; CRC cis rs9326248 0.954 rs521171 chr11:117064693 C/G cg26566898 chr11:117069891 TAGLN 0.44 9.44 0.46 6.99e-19 Blood protein levels; CRC cis rs9814567 1.000 rs3846056 chr3:134227292 A/G cg06541857 chr3:134203789 ANAPC13;CEP63 -0.41 -6.22 -0.32 1.48e-9 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs8177253 1.000 rs8177248 chr3:133479626 C/T cg08048268 chr3:133502702 NA -0.35 -6.43 -0.33 4.38e-10 Iron status biomarkers; CRC cis rs7927771 0.839 rs3817334 chr11:47650993 C/T cg05585544 chr11:47624801 NA -0.45 -8.12 -0.41 9.44e-15 Subjective well-being; CRC cis rs2976388 0.609 rs2257796 chr8:143808667 T/C cg22687807 chr8:143858763 LYNX1 0.51 9.11 0.45 8.37e-18 Urinary tract infection frequency; CRC cis rs4665809 0.590 rs962217 chr2:26438276 T/C cg08067268 chr2:26466485 HADHB;HADHA -0.67 -8.57 -0.43 3.98e-16 Gut microbiome composition (summer); CRC cis rs1215050 0.740 rs10025482 chr4:99053277 T/C cg05340658 chr4:99064831 C4orf37 0.48 7.33 0.37 1.82e-12 Waist-to-hip ratio adjusted for body mass index; CRC cis rs4481887 0.504 rs6587432 chr1:248355130 C/T cg00666640 chr1:248458726 OR2T12 0.43 7.05 0.36 1.05e-11 Common traits (Other); CRC cis rs1506636 0.646 rs805789 chr7:123221920 G/T cg03229431 chr7:123269106 ASB15 -0.6 -8.61 -0.43 3.12e-16 Plateletcrit;Platelet count; CRC cis rs2289583 0.642 rs8034281 chr15:75384227 A/G cg14664628 chr15:75095509 CSK -0.44 -6.29 -0.33 1.04e-9 Systemic lupus erythematosus; CRC cis rs4731207 0.596 rs10264210 chr7:124611594 G/C cg23710748 chr7:124431027 NA -0.39 -6.16 -0.32 2.1e-9 Cutaneous malignant melanoma; CRC cis rs10256972 0.685 rs10263665 chr7:1110628 A/G cg07308232 chr7:1071921 C7orf50 -0.44 -6.19 -0.32 1.79e-9 Longevity;Endometriosis; CRC cis rs12594515 1.000 rs11070464 chr15:45984776 C/A cg01629716 chr15:45996671 NA 0.41 8.51 0.42 6.27e-16 Waist circumference;Weight; CRC cis rs2549003 1.000 rs2070725 chr5:131821788 C/T cg21138405 chr5:131827807 IRF1 0.57 11.38 0.53 1.59e-25 Asthma (sex interaction); CRC cis rs57994353 0.600 rs10870172 chr9:139319469 G/A cg14119001 chr9:139324193 INPP5E -0.44 -5.9 -0.31 8.91e-9 Eosinophil counts;Cutaneous squamous cell carcinoma; CRC trans rs11039798 0.920 rs12279378 chr11:48571030 A/C cg03929089 chr4:120376271 NA 0.62 6.09 0.32 3.17e-9 Axial length; CRC cis rs7705042 0.828 rs1036209 chr5:141498632 T/A cg07392085 chr5:141489673 NDFIP1 0.47 7.41 0.38 1.07e-12 Asthma; CRC cis rs7216064 0.636 rs62084696 chr17:66038181 C/G cg12091567 chr17:66097778 LOC651250 0.91 13.9 0.61 6.8000000000000005e-35 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CRC cis rs1448094 0.549 rs10863085 chr12:86236328 G/A cg02569458 chr12:86230093 RASSF9 0.45 7.68 0.39 1.84e-13 Major depressive disorder; CRC cis rs9916302 0.706 rs7503081 chr17:37482673 A/G cg00129232 chr17:37814104 STARD3 0.56 6.98 0.36 1.67e-11 Glomerular filtration rate (creatinine); CRC cis rs2742417 1.000 rs9829631 chr3:45740558 T/C cg04837898 chr3:45731254 SACM1L -0.36 -5.87 -0.31 1.09e-8 Response to anti-depressant treatment in major depressive disorder; CRC cis rs17270561 0.636 rs77343532 chr6:25828828 G/A cg17691542 chr6:26056736 HIST1H1C 0.63 8.53 0.43 5.49e-16 Iron status biomarkers; CRC trans rs9929218 1.000 rs12448448 chr16:68802516 T/G cg04657470 chr2:198365150 HSPE1;HSPD1 -0.84 -11.92 -0.55 1.85e-27 Colorectal cancer; CRC cis rs8062405 0.755 rs4788080 chr16:28558081 C/T cg16576597 chr16:28551801 NUPR1 0.56 8.26 0.41 3.67e-15 Cognitive ability (multi-trait analysis);Cognitive ability; CRC cis rs12540874 0.542 rs4947582 chr7:50566090 C/T cg14593290 chr7:50529359 DDC -0.48 -6.95 -0.36 1.95e-11 Systemic sclerosis; CRC cis rs1957429 0.808 rs6573580 chr14:65331766 C/G cg23373153 chr14:65346875 NA 0.65 6.68 0.35 9.97e-11 Pediatric areal bone mineral density (radius); CRC cis rs2721195 0.967 rs748195 chr8:145682514 T/C cg15320075 chr8:145703422 NA 0.66 10.95 0.52 5.38e-24 Age at first birth; CRC cis rs6499255 0.951 rs12596823 chr16:69634757 A/C cg04110750 chr16:69646130 NFAT5 -0.56 -7.56 -0.38 4.18e-13 IgE levels; CRC cis rs9921222 0.521 rs11649255 chr16:357140 A/G cg08923669 chr16:420230 MRPL28 -0.59 -7.97 -0.4 2.7e-14 Bone mineral density (spine);Bone mineral density; CRC cis rs10504229 0.683 rs11786043 chr8:58133174 T/C cg05313129 chr8:58192883 C8orf71 -0.43 -6.11 -0.32 2.74e-9 Developmental language disorder (linguistic errors); CRC cis rs10193935 0.605 rs10169492 chr2:42401961 G/T cg27598129 chr2:42591480 NA -0.71 -7.96 -0.4 2.76e-14 Colonoscopy-negative controls vs population controls; CRC cis rs7212590 0.655 rs8067568 chr17:57999215 A/G cg10252138 chr17:58120427 NA -0.52 -5.76 -0.3 1.89e-8 Granulocyte percentage of myeloid white cells;Monocyte count;Monocyte percentage of white cells; CRC cis rs427394 0.582 rs274661 chr5:6704848 C/T cg15145174 chr5:6755386 POLS -0.46 -6.43 -0.33 4.4e-10 Menopause (age at onset); CRC cis rs9467773 1.000 rs1078679 chr6:26568741 C/T cg09904177 chr6:26538194 HMGN4 0.86 14.82 0.63 2.06e-38 Intelligence (multi-trait analysis); CRC cis rs35110281 0.782 rs4818856 chr21:45043495 A/G cg04455712 chr21:45112962 RRP1B 0.41 7.96 0.4 2.75e-14 Mean corpuscular volume; CRC cis rs968567 0.817 rs61896141 chr11:61556039 A/C cg07005513 chr11:61595956 FADS2 -0.51 -6.54 -0.34 2.34e-10 Blood metabolite levels;Rheumatoid arthritis;Vitiligo;Glycerophospholipid levels; CRC cis rs2243480 0.711 rs1626926 chr7:65435792 C/T cg12463550 chr7:65579703 CRCP 0.62 5.97 0.31 6.12e-9 Diabetic kidney disease; CRC cis rs7493 1.000 rs17876124 chr7:95045258 C/G cg17330251 chr7:94953956 PON1 -0.56 -7.25 -0.37 3.02e-12 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs9341808 0.714 rs9448911 chr6:80913859 A/G cg08355045 chr6:80787529 NA 0.37 6.23 0.32 1.43e-9 Sitting height ratio; CRC cis rs12760731 0.565 rs12037925 chr1:178160268 C/T cg00404053 chr1:178313656 RASAL2 1.04 10.92 0.52 6.54e-24 Obesity-related traits; CRC cis rs595982 0.559 rs117227130 chr19:49367959 A/G cg15549821 chr19:49342101 PLEKHA4 -0.56 -6.6 -0.34 1.62e-10 Red cell distribution width; CRC cis rs13064411 0.696 rs7619913 chr3:113017503 A/G cg18753928 chr3:113234510 CCDC52 -0.59 -7.72 -0.39 1.43e-13 Response to simvastatin treatment (PCSK9 protein level change); CRC cis rs7224737 1.000 rs7214921 chr17:40294025 T/C cg02450064 chr17:40260053 DHX58 -0.42 -6.13 -0.32 2.54e-9 Fibrinogen levels; CRC cis rs1552244 1.000 rs35220123 chr3:10083169 C/T cg00166722 chr3:10149974 C3orf24 0.71 9.49 0.46 4.86e-19 Alzheimer's disease; CRC cis rs1150668 0.699 rs1736895 chr6:28219826 G/A cg15845792 chr6:28175446 NA 0.5 7.39 0.38 1.22e-12 Pubertal anthropometrics; CRC cis rs4843747 0.605 rs4072779 chr16:88107290 C/T cg07865391 chr16:88106882 BANP 0.46 6.05 0.32 3.86e-9 Menopause (age at onset); CRC cis rs4290604 0.667 rs62183332 chr2:237952535 G/T cg23555395 chr2:238036564 NA 0.64 6.38 0.33 5.96e-10 Asthma; CRC cis rs1218582 0.772 rs4845400 chr1:154872523 C/T cg06221963 chr1:154839813 KCNN3 -0.77 -15.52 -0.65 3.69e-41 Prostate cancer; CRC cis rs17826219 0.568 rs59858012 chr17:29078582 C/T cg01831904 chr17:28903510 LRRC37B2 -0.62 -5.69 -0.3 2.83e-8 Body mass index; CRC cis rs7584330 0.628 rs7591065 chr2:238390739 G/T cg14458575 chr2:238380390 NA 0.57 7.91 0.4 3.84e-14 Prostate cancer; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg08120389 chr17:19881268 AKAP10 0.46 7.38 0.38 1.33e-12 Liver disease severity in Alagille syndrome; CRC cis rs1707322 0.717 rs2991988 chr1:46082431 C/A cg03146154 chr1:46216737 IPP -0.67 -9.51 -0.46 4.3e-19 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs2180341 0.521 rs12189967 chr6:127718058 G/A cg24812749 chr6:127587940 RNF146 0.48 7.07 0.36 9.08e-12 Breast cancer; CRC cis rs7412746 0.658 rs57818453 chr1:150763139 G/A cg15448220 chr1:150897856 SETDB1 0.54 7.59 0.39 3.39e-13 Melanoma; CRC cis rs9487051 0.872 rs9386793 chr6:109610002 C/A cg21918786 chr6:109611834 NA -0.45 -8.29 -0.42 2.86e-15 Reticulocyte fraction of red cells; CRC trans rs2303319 0.504 rs58622044 chr2:162596287 A/G cg06896663 chr8:82754093 SNX16 -0.69 -6.06 -0.32 3.82e-9 Cognitive function; CRC cis rs6502050 0.765 rs55905076 chr17:80105441 G/A cg19223190 chr17:80058835 NA 0.39 6.29 0.33 1e-9 Life satisfaction; CRC cis rs8060686 0.516 rs2290700 chr16:68288983 T/G cg26727032 chr16:67993705 SLC12A4 -0.63 -8.97 -0.44 2.3e-17 HDL cholesterol;Metabolic syndrome; CRC cis rs853679 0.517 rs2275508 chr6:28094731 T/C cg15786705 chr6:28176104 NA 0.74 9.41 0.46 8.75e-19 Depression; CRC cis rs1707322 1.000 rs785497 chr1:46591903 G/C cg03146154 chr1:46216737 IPP -0.59 -8.06 -0.41 1.44e-14 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs4692589 1.000 rs4692785 chr4:170938593 C/T cg19918862 chr4:170955249 NA 0.39 6.29 0.33 9.93e-10 Anxiety disorder; CRC cis rs3764563 1.000 rs1022413 chr19:15741984 G/A cg20725493 chr19:15740067 CYP4F8 -0.73 -7.61 -0.39 2.83e-13 Inflammatory biomarkers; CRC cis rs4604732 0.631 rs11490198 chr1:247625703 A/G cg12758973 chr1:247694275 LOC148824;OR2C3 0.42 6.14 0.32 2.32e-9 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CRC trans rs1728785 0.818 rs11648503 chr16:68598938 G/A cg04657470 chr2:198365150 HSPE1;HSPD1 0.76 9.0 0.44 1.83e-17 Ulcerative colitis; CRC cis rs344364 0.602 rs8044343 chr16:1881145 G/C cg09830162 chr16:1889614 FAHD1;C16orf73 -0.59 -8.47 -0.42 8.15e-16 Glomerular filtration rate in chronic kidney disease; CRC cis rs6570726 0.905 rs421032 chr6:145827771 A/G cg23711669 chr6:146136114 FBXO30 0.68 12.0 0.55 9.22e-28 Lobe attachment (rater-scored or self-reported); CRC cis rs6500395 0.775 rs7185541 chr16:48664681 A/G cg04672837 chr16:48644449 N4BP1 0.44 6.53 0.34 2.53e-10 Response to tocilizumab in rheumatoid arthritis; CRC trans rs6678914 1.000 rs12129456 chr1:202189087 T/G cg19977628 chr5:1262072 TERT 0.43 6.2 0.32 1.65e-9 Breast cancer (estrogen-receptor negative);Breast cancer; CRC cis rs9796 0.870 rs4923890 chr15:41258990 T/C cg18705301 chr15:41695430 NDUFAF1 0.34 5.75 0.3 2.01e-8 Menopause (age at onset); CRC cis rs7727544 0.735 rs270605 chr5:131651811 C/T cg07395648 chr5:131743802 NA -0.41 -6.47 -0.34 3.47e-10 Blood metabolite levels; CRC cis rs13343954 0.518 rs7252086 chr19:33534929 T/C cg17764715 chr19:33622953 WDR88 0.39 5.85 0.31 1.16e-8 Colorectal cancer; CRC cis rs13161895 1.000 rs12656814 chr5:179471556 G/A cg02702477 chr5:179499311 RNF130 0.55 6.26 0.33 1.18e-9 LDL cholesterol; CRC cis rs9467711 0.591 rs9467621 chr6:25851338 G/A cg08501292 chr6:25962987 TRIM38 1.15 9.94 0.48 1.63e-20 Autism spectrum disorder or schizophrenia; CRC cis rs7089973 0.624 rs61867965 chr10:116574794 A/T cg23260525 chr10:116636907 FAM160B1 0.34 7.82 0.4 7.31e-14 Bipolar disorder or attention deficit hyperactivity disorder; CRC cis rs651907 0.557 rs3806653 chr3:101396972 T/C cg11279151 chr3:101281821 RG9MTD1 -0.57 -7.74 -0.39 1.25e-13 Colorectal cancer; CRC cis rs3733585 0.579 rs4235356 chr4:10123106 G/C cg00071950 chr4:10020882 SLC2A9 -0.58 -9.47 -0.46 5.54e-19 Cleft plate (environmental tobacco smoke interaction); CRC cis rs3785574 0.582 rs62072238 chr17:61948841 A/T cg22520471 chr17:61851767 DDX42;CCDC47 0.42 5.8 0.3 1.58e-8 Height; CRC trans rs9814567 0.722 rs13083717 chr3:134348796 G/A cg07838205 chr1:110091179 GNAI3 -0.48 -5.98 -0.31 5.76e-9 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs10504229 0.683 rs57866073 chr8:58139138 A/G cg02290350 chr8:58132656 NA -0.56 -7.55 -0.38 4.44e-13 Developmental language disorder (linguistic errors); CRC cis rs2243480 1.000 rs1039664 chr7:65449716 T/G cg25985355 chr7:65971099 NA -0.47 -5.61 -0.3 4.34e-8 Diabetic kidney disease; CRC cis rs875971 0.929 rs778682 chr7:65837934 A/G cg18876405 chr7:65276391 NA 0.52 9.04 0.45 1.37e-17 Aortic root size; CRC cis rs1165668 0.727 rs2722176 chr12:104313943 T/C cg21863207 chr12:104234989 NT5DC3 0.48 7.16 0.37 5.39e-12 Coronary heart disease (SNP X SNP interaction); CRC cis rs1451375 0.657 rs12665904 chr7:50635399 A/G cg14593290 chr7:50529359 DDC 0.52 7.17 0.37 4.97e-12 Malaria; CRC cis rs853679 0.517 rs9380058 chr6:28127444 T/C cg25164649 chr6:28176230 NA 0.78 9.69 0.47 1.04e-19 Depression; CRC cis rs877426 0.515 rs57506460 chr13:114767789 G/A cg25338242 chr13:114786047 RASA3 0.39 6.05 0.32 4.04e-9 Facial morphology (factor 14, intercanthal width); CRC cis rs763121 0.853 rs5750668 chr22:39079964 T/C cg06544989 chr22:39130855 UNC84B 0.45 6.91 0.36 2.53e-11 Menopause (age at onset); CRC trans rs2727020 0.729 rs2204366 chr11:49349367 A/C cg03929089 chr4:120376271 NA 0.82 14.48 0.62 4.27e-37 Coronary artery disease; CRC cis rs908922 0.676 rs533917 chr1:152518294 A/G cg09873164 chr1:152488093 CRCT1 0.37 6.08 0.32 3.38e-9 Hair morphology; CRC cis rs11212617 1.000 rs7108522 chr11:108281004 A/G cg01991180 chr11:108092276 ATM;NPAT 0.44 6.58 0.34 1.82e-10 Response to metformin in type 2 diabetes (glycemic); CRC cis rs7772486 0.727 rs6941429 chr6:145952283 G/A cg13319975 chr6:146136371 FBXO30 -0.48 -7.05 -0.36 1.07e-11 Lobe attachment (rater-scored or self-reported); CRC cis rs35110281 0.693 rs2838345 chr21:45092715 C/T cg01579765 chr21:45077557 HSF2BP -0.36 -6.89 -0.36 2.78e-11 Mean corpuscular volume; CRC cis rs4268898 0.697 rs6714652 chr2:24383059 C/T cg06627628 chr2:24431161 ITSN2 0.43 6.19 0.32 1.8e-9 Asthma; CRC cis rs2974760 0.606 rs6600143 chr16:201389 A/C cg08400316 chr16:204221 HBZ -0.67 -10.65 -0.51 5.71e-23 Mean corpuscular volume;Mean corpuscular hemoglobin; CRC cis rs514406 0.792 rs481440 chr1:53344976 C/T cg27535305 chr1:53392650 SCP2 -0.42 -7.55 -0.38 4.2e-13 Monocyte count; CRC cis rs9914988 0.943 rs7217547 chr17:27106872 C/G cg19196414 chr17:27188595 MIR451;MIR144 0.4 5.84 0.31 1.28e-8 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs9837602 1.000 rs9873878 chr3:99711816 G/T cg07805332 chr3:99536008 MIR548G;C3orf26 -0.47 -6.2 -0.32 1.65e-9 Breast cancer; CRC cis rs13191362 1.000 rs35818596 chr6:163001874 C/G cg23758597 chr6:163146217 PARK2 -0.55 -6.12 -0.32 2.61e-9 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC trans rs7618501 1.000 rs11130218 chr3:49752372 C/T cg21659725 chr3:3221576 CRBN -0.9 -17.32 -0.69 3.07e-48 Intelligence (multi-trait analysis); CRC cis rs2270875 0.935 rs10505583 chr8:132981421 C/T cg24184792 chr8:132919238 EFR3A -0.65 -6.37 -0.33 6.26e-10 Response to cholinesterase inhibitors in Alzheimer's disease; CRC cis rs17711722 0.727 rs1880555 chr7:65432567 T/C cg02869306 chr7:64672164 INTS4L1 -0.35 -5.87 -0.31 1.04e-8 Calcium levels; CRC trans rs2727020 0.734 rs1164663 chr11:49294723 A/T cg03929089 chr4:120376271 NA 0.62 8.18 0.41 6.13e-15 Coronary artery disease; CRC trans rs17685 0.712 rs2158867 chr7:75815141 C/A cg19862616 chr7:65841803 NCRNA00174 0.96 16.54 0.67 3.79e-45 Coffee consumption;Coffee consumption (cups per day); CRC cis rs7208859 0.623 rs216439 chr17:28927884 T/C cg01831904 chr17:28903510 LRRC37B2 -0.58 -5.94 -0.31 7.45e-9 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs2204008 0.528 rs11503820 chr12:38395379 G/A cg26384229 chr12:38710491 ALG10B -0.51 -7.32 -0.37 1.86e-12 Bladder cancer; CRC cis rs13256369 0.851 rs13267036 chr8:8566685 G/A cg17143192 chr8:8559678 CLDN23 0.49 6.26 0.33 1.22e-9 Obesity-related traits; CRC cis rs780096 0.526 rs7594812 chr2:27611469 A/G cg12000995 chr2:27665139 KRTCAP3 -0.3 -6.17 -0.32 2.03e-9 Total body bone mineral density; CRC cis rs67478160 0.634 rs2144080 chr14:104258761 A/C cg01849466 chr14:104193079 ZFYVE21 -0.54 -10.07 -0.49 5.64e-21 Schizophrenia; CRC cis rs1568889 0.838 rs7131379 chr11:28085789 C/T cg06544937 chr11:28130018 METT5D1;KIF18A 0.92 15.47 0.65 5.89e-41 Bipolar disorder; CRC cis rs2739330 0.760 rs5751761 chr22:24243736 A/G cg11060661 chr22:24314208 DDT;DDTL -0.48 -8.08 -0.41 1.23e-14 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs6089584 0.889 rs6142923 chr20:60596617 C/T cg23262073 chr20:60523788 NA 0.49 7.17 0.37 5.12e-12 Body mass index; CRC cis rs853679 0.517 rs17711801 chr6:28092307 C/G cg18032046 chr6:28092343 ZSCAN16 -0.52 -6.08 -0.32 3.3e-9 Depression; CRC trans rs12478296 1.000 rs6739247 chr2:243039189 C/A cg18288967 chr1:45987694 PRDX1 0.68 7.53 0.38 4.99e-13 Obesity-related traits; CRC cis rs2730245 0.527 rs712197 chr7:158660846 C/G cg24397884 chr7:158709396 WDR60 0.94 11.07 0.52 2e-24 Height; CRC cis rs9287719 0.649 rs6720112 chr2:10725719 T/C cg00105475 chr2:10696890 NA 0.44 7.0 0.36 1.43e-11 Prostate cancer; CRC cis rs4481887 0.927 rs6671702 chr1:248482851 G/A cg00666640 chr1:248458726 OR2T12 0.46 7.97 0.4 2.59e-14 Common traits (Other); CRC cis rs57590327 0.555 rs13084107 chr3:81833577 T/C cg07356753 chr3:81810745 GBE1 -0.65 -8.89 -0.44 4.25e-17 Extraversion; CRC cis rs7605827 0.893 rs1024871 chr2:15626162 C/T cg19274914 chr2:15703543 NA 0.39 5.92 0.31 8.14e-9 Educational attainment (years of education); CRC cis rs501120 0.584 rs11592445 chr10:44732945 G/T cg09554077 chr10:44749378 NA 0.64 7.06 0.36 9.84e-12 Coronary artery disease;Coronary heart disease; CRC cis rs7703744 0.634 rs3797340 chr5:118691737 C/G cg23917399 chr5:118691751 TNFAIP8 0.41 5.67 0.3 3.08e-8 Lobe attachment (rater-scored or self-reported); CRC cis rs910316 1.000 rs2098297 chr14:75619118 G/T cg03030879 chr14:75389066 RPS6KL1 0.43 6.83 0.35 4.03e-11 Height; CRC cis rs3733585 0.783 rs13148371 chr4:10032561 C/T cg00071950 chr4:10020882 SLC2A9 0.67 12.53 0.57 9.97e-30 Cleft plate (environmental tobacco smoke interaction); CRC trans rs916888 0.610 rs199530 chr17:44836653 C/T cg22433210 chr17:43662623 NA -0.59 -7.39 -0.38 1.2e-12 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs231513 0.954 rs231512 chr17:41965831 G/A cg26893861 chr17:41843967 DUSP3 -0.69 -6.32 -0.33 8.59e-10 Cognitive function; CRC cis rs514406 0.679 rs499239 chr1:53310594 A/G cg08859206 chr1:53392774 SCP2 -0.6 -9.66 -0.47 1.3e-19 Monocyte count; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg00331096 chr20:22564947 FOXA2 0.44 6.49 0.34 3.09e-10 Intelligence (multi-trait analysis); CRC cis rs9894429 0.646 rs9904137 chr17:79613925 C/T cg21984481 chr17:79567631 NPLOC4 -0.43 -7.41 -0.38 1.08e-12 Eye color traits; CRC cis rs6866344 0.697 rs11743893 chr5:178125194 C/T cg10224037 chr5:178157518 ZNF354A 0.72 11.04 0.52 2.59e-24 Neutrophil percentage of white cells; CRC trans rs1864585 0.520 rs17776622 chr8:10676497 T/C cg26278703 chr11:58910052 FAM111A 0.54 6.3 0.33 9.29e-10 Neutrophil percentage of white cells;Lymphocyte percentage of white cells; CRC cis rs514406 0.793 rs12402415 chr1:53218539 G/T cg24675658 chr1:53192096 ZYG11B 0.58 9.0 0.44 1.87e-17 Monocyte count; CRC cis rs9467603 0.925 rs1892251 chr6:25769349 T/C cg08501292 chr6:25962987 TRIM38 -0.65 -6.11 -0.32 2.76e-9 Intelligence (multi-trait analysis); CRC trans rs7849782 0.604 rs10121600 chr9:104378003 C/T cg26072213 chr5:52095705 ITGA1;PELO 0.49 6.38 0.33 6.18e-10 Coronary artery aneurysm in Kawasaki disease; CRC cis rs2204008 0.683 rs11519834 chr12:38053575 T/A cg26384229 chr12:38710491 ALG10B 0.69 9.17 0.45 5.4e-18 Bladder cancer; CRC cis rs9303401 0.659 rs12940212 chr17:56674474 T/C cg02118635 chr17:56770003 RAD51C;TEX14 0.81 9.7 0.47 9.7e-20 Cognitive test performance; CRC cis rs926938 0.584 rs2798663 chr1:115363582 G/A cg12756093 chr1:115239321 AMPD1 0.57 8.39 0.42 1.48e-15 Autism; CRC trans rs61931739 0.534 rs7138522 chr12:34039762 G/A cg26384229 chr12:38710491 ALG10B 0.53 6.76 0.35 6.43e-11 Morning vs. evening chronotype; CRC cis rs11764590 0.715 rs62444907 chr7:2083267 C/T cg23378565 chr7:2036160 MAD1L1 -0.43 -5.86 -0.31 1.13e-8 Neuroticism; CRC cis rs8062405 1.000 rs3088215 chr16:28853996 A/C cg16576597 chr16:28551801 NUPR1 0.48 6.83 0.35 4.24e-11 Cognitive ability (multi-trait analysis);Cognitive ability; CRC cis rs4268898 0.636 rs72787371 chr2:24570073 T/A cg06627628 chr2:24431161 ITSN2 -0.81 -11.22 -0.53 5.83e-25 Asthma; CRC trans rs10838798 0.523 rs4752907 chr11:48170581 G/A cg03929089 chr4:120376271 NA -0.48 -6.73 -0.35 7.56e-11 Height; CRC cis rs6456156 0.716 rs6905876 chr6:167521562 C/T cg07513332 chr6:167530253 CCR6 0.36 5.87 0.31 1.05e-8 Primary biliary cholangitis; CRC cis rs4664293 0.669 rs2042778 chr2:160528630 A/G cg08347373 chr2:160653686 CD302 0.39 6.52 0.34 2.67e-10 Monocyte percentage of white cells; CRC cis rs7552404 1.000 rs4949876 chr1:76173377 C/T cg03433033 chr1:76189801 ACADM 0.81 11.14 0.52 1.17e-24 Blood metabolite levels;Acylcarnitine levels; CRC cis rs4727027 0.680 rs6464941 chr7:148826352 A/G cg12479418 chr7:148823350 ZNF425;ZNF398 0.48 6.22 0.32 1.53e-9 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC cis rs12325245 0.536 rs34676074 chr16:58549321 G/C cg01472538 chr16:58549086 SETD6 1.2 7.61 0.39 2.9e-13 Schizophrenia; CRC cis rs9814567 1.000 rs1874883 chr3:134205071 G/T cg06109529 chr3:134205091 CEP63;ANAPC13 -0.81 -12.47 -0.57 1.67e-29 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs1728785 0.818 rs1645984 chr16:68628850 T/C cg02972257 chr16:68554789 NA -0.59 -6.91 -0.36 2.54e-11 Ulcerative colitis; CRC cis rs1552244 1.000 rs12152512 chr3:10143770 C/T cg18598329 chr3:10140678 FANCD2;C3orf24 -0.89 -13.07 -0.58 9.78e-32 Alzheimer's disease; CRC cis rs4332037 0.539 rs11763750 chr7:2080114 G/A cg13880726 chr7:1868755 MAD1L1 -0.45 -5.65 -0.3 3.53e-8 Bipolar disorder; CRC cis rs7705042 0.865 rs2338821 chr5:141509433 A/G cg08523384 chr5:141488047 NDFIP1 -0.32 -5.77 -0.3 1.87e-8 Asthma; CRC cis rs853679 0.517 rs9468286 chr6:28079428 C/T cg12963246 chr6:28129442 ZNF389 0.5 5.8 0.3 1.53e-8 Depression; CRC cis rs977987 0.750 rs4888414 chr16:75447233 A/G cg03315344 chr16:75512273 CHST6 0.54 9.08 0.45 1.04e-17 Dupuytren's disease; CRC cis rs3820068 0.626 rs11580170 chr1:15909744 C/T cg27534772 chr1:16042836 PLEKHM2 0.51 9.33 0.46 1.56e-18 Systolic blood pressure; CRC cis rs2204008 0.775 rs11514370 chr12:38305566 G/A cg26384229 chr12:38710491 ALG10B 0.68 9.69 0.47 1.09e-19 Bladder cancer; CRC cis rs10991814 0.920 rs10512211 chr9:94104260 C/G cg14446406 chr9:93919335 NA 0.56 6.29 0.33 1.03e-9 Neutrophil percentage of granulocytes; CRC cis rs11098499 0.954 rs10005644 chr4:120298477 T/C cg24375607 chr4:120327624 NA 0.51 7.86 0.4 5.5e-14 Corneal astigmatism; CRC cis rs12477438 0.501 rs6727749 chr2:99793590 C/T cg26064155 chr2:99771622 LIPT1;TSGA10 0.77 13.13 0.59 5.79e-32 Chronic sinus infection; CRC cis rs6860806 0.661 rs28472559 chr5:131581611 G/A cg22638593 chr5:131593259 PDLIM4 0.39 7.22 0.37 3.7e-12 Breast cancer; CRC cis rs2836974 0.545 rs3167757 chr21:40714478 C/T cg11644478 chr21:40555479 PSMG1 0.48 7.02 0.36 1.24e-11 Cognitive function; CRC cis rs7618915 0.571 rs7623199 chr3:52605974 C/T cg05573699 chr3:52720067 GNL3;PBRM1 -0.44 -6.23 -0.32 1.44e-9 Bipolar disorder; CRC cis rs9400271 0.632 rs9487020 chr6:109587672 A/G cg01475377 chr6:109611718 NA -0.35 -6.1 -0.32 3e-9 Sum neutrophil eosinophil counts;Sum basophil neutrophil counts;White blood cell count;Neutrophil count;Myeloid white cell count;Granulocyte count; CRC cis rs1865760 0.625 rs9393681 chr6:26008260 A/G cg18357526 chr6:26021779 HIST1H4A 0.41 5.98 0.31 5.92e-9 Height; CRC cis rs6502050 0.698 rs6502076 chr17:80121978 A/G cg09264619 chr17:80180166 NA -0.35 -5.93 -0.31 7.47e-9 Life satisfaction; CRC cis rs6565180 0.926 rs8046445 chr16:30386262 A/G cg17640201 chr16:30407289 ZNF48 -0.83 -15.22 -0.64 5.73e-40 Tonsillectomy; CRC cis rs798554 0.796 rs2158694 chr7:2863443 T/G cg13628971 chr7:2884303 GNA12 0.54 7.3 0.37 2.18e-12 Height; CRC cis rs6964587 0.967 rs6970743 chr7:91744311 C/G cg17063962 chr7:91808500 NA 0.83 14.57 0.63 1.95e-37 Breast cancer; CRC cis rs4975616 0.869 rs31484 chr5:1337906 A/T cg26373071 chr5:1325741 CLPTM1L 0.55 9.97 0.48 1.23e-20 Lung cancer; CRC cis rs11971779 0.680 rs6962366 chr7:139043867 G/A cg23387468 chr7:139079360 LUC7L2 0.41 7.04 0.36 1.14e-11 Diisocyanate-induced asthma; CRC cis rs875971 1.000 rs7783613 chr7:65805261 C/T cg18912574 chr7:65842487 NCRNA00174 -0.36 -6.11 -0.32 2.74e-9 Aortic root size; CRC cis rs2346177 0.580 rs1530628 chr2:46670941 A/G cg26688816 chr2:46740690 ATP6V1E2 -0.58 -10.11 -0.49 4.29e-21 HDL cholesterol; CRC cis rs75804782 0.935 rs61332075 chr2:239316560 G/C cg18131467 chr2:239335373 ASB1 -0.67 -5.71 -0.3 2.57e-8 Morning vs. evening chronotype;Chronotype; CRC cis rs736408 0.812 rs9324 chr3:52825585 T/C cg08222913 chr3:52553049 STAB1 -0.34 -5.97 -0.31 6.24e-9 Bipolar disorder; CRC cis rs651907 0.557 rs62284199 chr3:101478531 T/G cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.58 7.73 0.39 1.3e-13 Colorectal cancer; CRC cis rs77861329 1.000 rs59890038 chr3:52147850 A/G cg08692210 chr3:52188851 WDR51A 0.82 7.44 0.38 8.9e-13 Macrophage inflammatory protein 1b levels; CRC cis rs6089584 0.816 rs744778 chr20:60631365 A/G cg13770153 chr20:60521292 NA -0.61 -9.26 -0.45 2.71e-18 Body mass index; CRC trans rs73162807 0.655 rs73160972 chr3:146422109 C/T cg26896787 chr1:228603707 TRIM17 -0.59 -5.99 -0.31 5.61e-9 Platelet-derived growth factor BB levels; CRC cis rs9427116 1.000 rs9330261 chr1:154634998 T/A cg17218026 chr1:154582156 ADAR 0.43 6.54 0.34 2.39e-10 Blood protein levels; CRC cis rs17253792 0.749 rs45458197 chr14:56145018 A/T cg01858014 chr14:56050164 KTN1 -0.88 -7.22 -0.37 3.55e-12 Putamen volume; CRC cis rs801193 0.569 rs4717315 chr7:66178325 C/T cg00343986 chr7:65444356 GUSB 0.45 6.27 0.33 1.12e-9 Aortic root size; CRC cis rs896543 0.702 rs12692188 chr2:237495929 A/G cg25295825 chr2:237489920 CXCR7 0.47 7.83 0.4 6.92e-14 Alcohol dependence (age at onset); CRC cis rs2860975 1.000 rs12781471 chr10:96765362 T/C cg09036531 chr10:96991505 NA -0.42 -5.79 -0.3 1.65e-8 Immune response to smallpox vaccine (IL-6); CRC cis rs4077468 1.000 rs4077468 chr1:205914757 A/G cg13172432 chr1:205912842 SLC26A9 -0.35 -6.11 -0.32 2.76e-9 Cystic fibrosis-related diabetes; CRC cis rs17532515 0.628 rs6840266 chr4:141479999 T/C cg09181644 chr4:141490428 UCP1 0.32 5.78 0.3 1.71e-8 Select biomarker traits; CRC trans rs3960554 0.808 rs112962015 chr7:75659303 C/T cg19862616 chr7:65841803 NCRNA00174 0.69 8.15 0.41 7.44e-15 Eotaxin levels; CRC cis rs10791323 0.569 rs1119851 chr11:133742842 T/C cg06766960 chr11:133703094 NA -0.35 -6.44 -0.33 4.33e-10 Childhood ear infection; CRC trans rs9341835 0.740 rs9294215 chr6:64151771 C/G cg13657004 chr13:50234944 EBPL -0.36 -6.08 -0.32 3.38e-9 Schizophrenia; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg00516597 chr3:25824837 NGLY1 0.48 6.76 0.35 6.18e-11 Response to antipsychotic treatment; CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg03689054 chr17:81037743 METRNL 0.38 6.0 0.31 5.19e-9 Obesity-related traits; CRC cis rs281302 0.621 rs12591490 chr15:47732441 C/T cg13159054 chr15:47721715 NA -0.43 -6.58 -0.34 1.84e-10 Educational attainment (years of education);Cognitive ability (multi-trait analysis); CRC cis rs2072510 0.593 rs2540499 chr12:96399869 A/C cg09636302 chr12:96389483 HAL 0.5 6.48 0.34 3.42e-10 Metabolite levels (small molecules and protein measures); CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg07628558 chr20:56964831 VAPB -0.5 -6.29 -0.33 1.03e-9 Diisocyanate-induced asthma; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg18959139 chr7:72993101 TBL2 0.41 6.2 0.32 1.7e-9 Intelligence (multi-trait analysis); CRC cis rs1448094 0.512 rs6539933 chr12:86247611 T/C cg18827107 chr12:86230957 RASSF9 -0.45 -7.47 -0.38 7.34e-13 Major depressive disorder; CRC cis rs2976388 1.000 rs2920294 chr8:143765326 C/G cg24046110 chr8:143859143 LYNX1 -0.38 -6.6 -0.34 1.65e-10 Urinary tract infection frequency; CRC cis rs10504229 0.775 rs55825382 chr8:58157605 G/A cg08219700 chr8:58056026 NA 0.46 5.75 0.3 2.05e-8 Developmental language disorder (linguistic errors); CRC cis rs17253792 0.822 rs79291233 chr14:56065302 G/C cg01858014 chr14:56050164 KTN1 -0.85 -6.69 -0.35 9.81e-11 Putamen volume; CRC cis rs11098699 0.821 rs6811630 chr4:124222254 G/A cg09941581 chr4:124220074 SPATA5 0.43 6.39 0.33 5.51e-10 Mosquito bite size; CRC cis rs801193 0.844 rs732465 chr7:65998450 T/C cg05627663 chr7:65219948 SNORA22;CCT6P1 0.43 6.39 0.33 5.66e-10 Aortic root size; CRC cis rs4713118 0.513 rs149878 chr6:27878738 T/G cg02683197 chr6:28174875 NA 0.7 9.9 0.48 2.16e-20 Parkinson's disease; CRC cis rs1322512 1.000 rs2758816 chr6:152968338 A/T cg03415253 chr6:152958462 SYNE1 -0.44 -6.76 -0.35 6.31e-11 Tonometry; CRC cis rs11098499 0.863 rs3822194 chr4:120471648 A/G cg09307838 chr4:120376055 NA 0.67 10.27 0.49 1.24e-21 Corneal astigmatism; CRC cis rs40363 0.951 rs250632 chr16:3523047 C/T cg22508957 chr16:3507546 NAT15 0.9 11.1 0.52 1.6e-24 Tuberculosis; CRC cis rs881375 0.967 rs10739580 chr9:123695282 C/T cg09586646 chr9:123605570 PSMD5;LOC253039 0.47 6.49 0.34 3.18e-10 Rheumatoid arthritis; CRC cis rs58235267 0.591 rs2162014 chr2:63345507 C/A cg17519650 chr2:63277830 OTX1 0.45 6.23 0.32 1.43e-9 Prostate-specific antigen levels (conditioned on lead SNPs); CRC cis rs13256369 1.000 rs12545771 chr8:8567977 C/G cg06636001 chr8:8085503 FLJ10661 0.49 6.2 0.32 1.67e-9 Obesity-related traits; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg10436540 chr17:4047319 ZZEF1;CYB5D2 0.49 7.09 0.36 8.47e-12 Response to antipsychotic treatment; CRC cis rs853679 0.760 rs9468317 chr6:28198456 A/G cg02683197 chr6:28174875 NA 0.6 6.33 0.33 7.97e-10 Depression; CRC cis rs7193541 0.965 rs4402594 chr16:74701360 C/T cg01733217 chr16:74700730 RFWD3 0.85 15.55 0.65 2.87e-41 Multiple myeloma; CRC cis rs2721195 1.000 rs6599530 chr8:145677418 C/G cg17328964 chr8:145687451 CYHR1 0.68 12.22 0.56 1.46e-28 Age at first birth; CRC cis rs7680126 0.633 rs2024280 chr4:10291813 A/G cg11266682 chr4:10021025 SLC2A9 -0.46 -6.8 -0.35 5.03e-11 Urate levels in lean individuals;Urate levels in overweight individuals;Urate levels in obese individuals; CRC cis rs6424115 1.000 rs974698 chr1:24132785 C/T cg15997130 chr1:24165203 NA 0.69 10.77 0.51 2.19e-23 Immature fraction of reticulocytes; CRC cis rs10751667 1.000 rs10902246 chr11:953674 T/C ch.11.42038R chr11:967971 AP2A2 0.68 11.51 0.54 5.56e-26 Alzheimer's disease (late onset); CRC cis rs6540559 1.000 rs1044516 chr1:209959614 G/T cg21951975 chr1:209979733 IRF6 0.47 6.83 0.35 4.12e-11 Cleft lip with or without cleft palate; CRC trans rs7726839 0.540 rs56325086 chr5:640728 G/A cg11887960 chr12:57824829 NA 0.59 6.58 0.34 1.89e-10 Obesity-related traits; CRC cis rs3764400 0.567 rs8071879 chr17:46217457 G/A cg10706073 chr17:46328419 SKAP1 0.59 6.36 0.33 6.7e-10 Body mass index; CRC cis rs4843747 0.671 rs4075998 chr16:88106776 G/A cg17633681 chr16:88106987 BANP 0.87 16.24 0.67 5.81e-44 Menopause (age at onset); CRC cis rs2425143 0.687 rs6119649 chr20:34369596 G/A cg04508476 chr20:34239394 CPNE1;RBM12 0.48 6.08 0.32 3.36e-9 Blood protein levels; CRC cis rs17376456 0.825 rs1470150 chr5:93138654 C/T cg21475434 chr5:93447410 FAM172A -0.61 -6.59 -0.34 1.7e-10 Diabetic retinopathy; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg05300939 chr11:44587523 CD82 0.41 6.24 0.33 1.31e-9 Intelligence (multi-trait analysis); CRC cis rs612683 0.894 rs10875290 chr1:100853755 G/T cg06223162 chr1:101003688 GPR88 0.37 6.69 0.35 9.55e-11 Breast cancer; CRC cis rs2179367 0.920 rs560051 chr6:149666977 G/A cg07828024 chr6:149772892 ZC3H12D -0.38 -6.35 -0.33 7.18e-10 Dupuytren's disease; CRC cis rs13256369 1.000 rs10095733 chr8:8574646 A/G cg06671706 chr8:8559999 CLDN23 0.54 8.05 0.41 1.51e-14 Obesity-related traits; CRC cis rs1832871 0.711 rs9456266 chr6:158714422 A/G cg07165851 chr6:158734300 TULP4 0.62 7.76 0.39 1.11e-13 Height; CRC cis rs8044868 0.530 rs2241411 chr16:72144493 T/C cg23815491 chr16:72088622 HP 0.49 7.09 0.36 8.15e-12 Body mass index (change over time) in cancer or chronic obstructive pulmonary disease;Body mass index (change over time) in cancer; CRC trans rs1005277 0.579 rs2474608 chr10:38457109 C/T cg27523141 chr10:43048294 ZNF37B 0.5 7.32 0.37 1.98e-12 Extrinsic epigenetic age acceleration; CRC cis rs4731207 0.596 rs10081336 chr7:124575945 A/G cg23710748 chr7:124431027 NA -0.44 -6.94 -0.36 2.09e-11 Cutaneous malignant melanoma; CRC cis rs2739330 0.828 rs2154593 chr22:24252085 A/G cg24846343 chr22:24311635 DDTL 0.86 15.05 0.64 2.49e-39 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs7829975 0.501 rs2980769 chr8:8320291 G/A cg08975724 chr8:8085496 FLJ10661 0.46 7.1 0.36 7.8e-12 Mood instability; CRC cis rs28386778 0.897 rs11079510 chr17:61820902 T/C cg06601766 chr17:61851465 DDX42;CCDC47 0.43 5.93 0.31 7.84e-9 Prudent dietary pattern; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg24317988 chr10:33247433 ITGB1 0.42 7.08 0.36 9.04e-12 Liver disease severity in Alagille syndrome; CRC cis rs9486715 1.000 rs11153085 chr6:97066355 A/T cg18709589 chr6:96969512 KIAA0776 -0.47 -6.63 -0.34 1.35e-10 Headache; CRC cis rs10028773 0.600 rs4001390 chr4:120265783 G/C cg09307838 chr4:120376055 NA 0.62 9.69 0.47 1.07e-19 Educational attainment; CRC cis rs6912958 0.559 rs1201409 chr6:88055264 T/C cg08069147 chr6:88032118 GJB7;C6orf162 0.69 11.27 0.53 3.92e-25 Monocyte percentage of white cells; CRC cis rs738322 0.967 rs6001038 chr22:38570585 A/G cg25457927 chr22:38595422 NA -0.35 -7.4 -0.38 1.13e-12 Cutaneous nevi; CRC cis rs2535633 0.631 rs2710313 chr3:52969529 T/A cg15147215 chr3:52552868 STAB1 0.42 6.73 0.35 7.78e-11 Body mass index; CRC cis rs6456156 1.000 rs9457274 chr6:167520865 G/T cg05540913 chr6:167530185 CCR6 0.33 5.83 0.31 1.3e-8 Primary biliary cholangitis; CRC cis rs8044995 0.563 rs55968019 chr16:68398111 G/A cg09835421 chr16:68378352 PRMT7 -0.78 -8.22 -0.41 4.62e-15 Schizophrenia; CRC cis rs28719689 0.541 rs28376074 chr8:1274394 A/T cg22761795 chr8:1265118 NA 0.65 6.68 0.35 1.02e-10 Colonoscopy-negative controls vs population controls; CRC cis rs11866815 0.649 rs56355849 chr16:380641 T/C cg00101154 chr16:420108 MRPL28 0.53 5.71 0.3 2.5e-8 Body mass index; CRC cis rs9549367 0.789 rs3861720 chr13:113906097 A/G cg18105134 chr13:113819100 PROZ -0.74 -10.54 -0.5 1.38e-22 Platelet distribution width; CRC cis rs9303401 1.000 rs6503882 chr17:56915761 T/C cg02118635 chr17:56770003 RAD51C;TEX14 0.55 8.15 0.41 7.56e-15 Cognitive test performance; CRC trans rs877282 0.735 rs111609055 chr10:826539 A/G cg22713356 chr15:30763199 NA 0.8 9.27 0.46 2.53e-18 Uric acid levels; CRC cis rs28386778 0.734 rs7210724 chr17:61799198 T/C cg22520471 chr17:61851767 DDX42;CCDC47 0.73 11.17 0.52 9.08e-25 Prudent dietary pattern; CRC cis rs427941 0.632 rs201502 chr7:101759561 C/T cg06246474 chr7:101738831 CUX1 -0.4 -6.21 -0.32 1.63e-9 Plasma omega-3 polyunsaturated fatty acid level (eicosapentaenoic acid); CRC trans rs2321882 0.834 rs17682784 chr13:59459934 C/T cg04268950 chr11:130298854 ADAMTS8 -0.45 -5.99 -0.31 5.64e-9 Body mass index; CRC cis rs11719291 0.833 rs11715835 chr3:48770732 C/T cg07636037 chr3:49044803 WDR6 -0.82 -6.89 -0.36 2.83e-11 Cognitive function; CRC cis rs997295 0.570 rs7170299 chr15:67872718 A/G cg24247231 chr15:67904302 MAP2K5 -0.33 -5.62 -0.3 4.16e-8 Motion sickness; CRC cis rs875971 0.862 rs2901152 chr7:65765004 G/A cg12463550 chr7:65579703 CRCP -0.49 -6.67 -0.35 1.09e-10 Aortic root size; CRC cis rs1048238 0.935 rs761760 chr1:16342419 A/G cg24140574 chr1:16342155 HSPB7 0.47 6.74 0.35 7.16e-11 Systolic blood pressure; CRC cis rs2836974 0.932 rs8129416 chr21:40617145 C/T cg11644478 chr21:40555479 PSMG1 0.8 12.18 0.56 2.05e-28 Cognitive function; CRC cis rs10504229 0.728 rs17804365 chr8:58151537 C/A cg21724239 chr8:58056113 NA 0.62 8.38 0.42 1.51e-15 Developmental language disorder (linguistic errors); CRC cis rs8067545 0.750 rs888423 chr17:19999409 G/A cg13482628 chr17:19912719 NA 0.44 7.06 0.36 1e-11 Schizophrenia; CRC trans rs2727020 0.521 rs2088526 chr11:49531968 G/A cg03929089 chr4:120376271 NA 0.76 10.12 0.49 3.85e-21 Coronary artery disease; CRC cis rs10751667 0.666 rs7395823 chr11:942701 T/C cg01483505 chr11:975446 AP2A2 0.44 7.24 0.37 3.16e-12 Alzheimer's disease (late onset); CRC cis rs4665809 0.941 rs11126336 chr2:26245931 C/T cg22920501 chr2:26401640 FAM59B -0.54 -7.17 -0.37 4.93e-12 Gut microbiome composition (summer); CRC cis rs6427782 0.602 rs4915390 chr1:199824908 G/C cg07208853 chr1:200005219 NR5A2 0.23 5.94 0.31 7.33e-9 Menarche (age at onset); CRC cis rs7107174 1.000 rs10899452 chr11:77995143 A/C cg02023728 chr11:77925099 USP35 0.46 6.83 0.35 4.11e-11 Testicular germ cell tumor; CRC trans rs7618501 0.966 rs13063621 chr3:49821625 T/C cg21665057 chr3:196295764 WDR53;FBXO45 0.86 15.78 0.66 3.78e-42 Intelligence (multi-trait analysis); CRC cis rs2032447 0.966 rs7756117 chr6:26046565 A/G cg03264133 chr6:25882463 NA 0.41 5.71 0.3 2.58e-8 Intelligence (multi-trait analysis); CRC cis rs2576037 0.526 rs658756 chr18:44431832 A/G cg24750912 chr18:44543259 TCEB3CL;KATNAL2 0.28 5.77 0.3 1.82e-8 Personality dimensions; CRC cis rs753778 0.667 rs6578153 chr8:142209543 C/T cg23750338 chr8:142222470 SLC45A4 0.44 7.51 0.38 5.5e-13 Reticulocyte fraction of red cells;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; CRC cis rs6831352 0.725 rs2602846 chr4:100025151 T/A cg12011299 chr4:100065546 ADH4 0.49 9.27 0.46 2.46e-18 Alcohol dependence; CRC cis rs7208859 0.573 rs8070182 chr17:29135594 A/C cg13385521 chr17:29058706 SUZ12P 0.69 7.91 0.4 4.03e-14 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs2985684 0.948 rs2883437 chr14:50031666 A/G cg23565292 chr14:50234668 KLHDC2 -0.45 -6.34 -0.33 7.51e-10 Carotid intima media thickness; CRC cis rs72634258 0.786 rs4405150 chr1:8173672 T/C cg26816564 chr1:7831052 VAMP3 -0.53 -6.19 -0.32 1.78e-9 Inflammatory bowel disease; CRC cis rs12681287 0.517 rs34596274 chr8:87517679 C/T cg27223183 chr8:87520930 FAM82B -0.58 -7.95 -0.4 2.93e-14 Caudate activity during reward; CRC cis rs2032447 0.714 rs199726 chr6:25953360 G/A cg03264133 chr6:25882463 NA -0.52 -7.34 -0.38 1.67e-12 Intelligence (multi-trait analysis); CRC cis rs7208859 0.673 rs55904046 chr17:29215391 G/A cg01831904 chr17:28903510 LRRC37B2 -0.54 -5.65 -0.3 3.39e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs4363385 0.647 rs1995308 chr1:153014082 A/T cg25856811 chr1:152973957 SPRR3 -0.22 -6.08 -0.32 3.4e-9 Inflammatory skin disease; CRC cis rs2243480 0.708 rs13242216 chr7:65898277 T/C cg18252515 chr7:66147081 NA -1.27 -14.62 -0.63 1.25e-37 Diabetic kidney disease; CRC trans rs4824093 0.610 rs4141437 chr22:50243719 C/G cg09872104 chr7:134855509 C7orf49 0.83 7.42 0.38 9.79e-13 Amyotrophic lateral sclerosis (sporadic); CRC cis rs6860806 0.661 rs334902 chr5:131586559 C/G cg20512303 chr5:131592959 PDLIM4 0.37 6.89 0.36 2.8e-11 Breast cancer; CRC cis rs703842 0.964 rs10431552 chr12:58178148 G/A cg00677455 chr12:58241039 CTDSP2 0.64 8.61 0.43 3.15e-16 Multiple sclerosis; CRC cis rs4713118 0.616 rs9348789 chr6:28025486 C/T cg12273811 chr6:28175739 NA 0.62 8.29 0.42 2.87e-15 Parkinson's disease; CRC cis rs1183201 0.505 rs1165201 chr6:25874823 A/C cg03517284 chr6:25882590 NA -0.8 -12.22 -0.56 1.4e-28 Uric acid levels; CRC cis rs7493 0.760 rs17876092 chr7:95053313 C/A cg21856205 chr7:94953877 PON1 -0.54 -6.77 -0.35 6.07e-11 Yu-Zhi constitution type in type 2 diabetes; CRC trans rs66759488 0.739 rs10851451 chr15:47608991 A/G cg14201387 chr1:221737206 NA -0.44 -6.41 -0.33 4.99e-10 Lung cancer; CRC trans rs58688157 0.705 rs12800061 chr11:587425 C/A cg19188899 chr13:112838565 NA -0.42 -6.31 -0.33 8.84e-10 Systemic lupus erythematosus; CRC cis rs2070488 0.965 rs2051216 chr3:38562288 C/T cg01465620 chr3:38496096 LOC100128640;ACVR2B -0.89 -16.47 -0.67 7.23e-45 Electrocardiographic conduction measures; CRC cis rs7659604 0.539 rs7686084 chr4:122764725 A/C cg06713675 chr4:122721982 EXOSC9 -0.51 -8.3 -0.42 2.69e-15 Type 2 diabetes; CRC cis rs7089973 0.604 rs11196942 chr10:116596872 G/A cg23260525 chr10:116636907 FAM160B1 0.38 8.79 0.44 8.47e-17 Bipolar disorder or attention deficit hyperactivity disorder; CRC cis rs7255436 0.965 rs12981318 chr19:8451430 G/A cg10174797 chr19:8464628 RAB11B 0.44 7.7 0.39 1.62e-13 HDL cholesterol; CRC cis rs7119 0.635 rs867916 chr15:77882860 A/G cg10437265 chr15:77819839 NA -0.48 -8.06 -0.41 1.42e-14 Type 2 diabetes; CRC cis rs34779708 0.733 rs3936502 chr10:35549218 C/T cg03585969 chr10:35415529 CREM 0.52 6.79 0.35 5.37e-11 Inflammatory bowel disease;Crohn's disease; CRC cis rs17092148 1.000 rs62211617 chr20:33400355 C/G cg08999081 chr20:33150536 PIGU -0.42 -5.62 -0.3 4.16e-8 Neuroticism; CRC cis rs904251 0.802 rs2646933 chr6:37402070 C/G cg01843034 chr6:37503916 NA -0.34 -5.62 -0.3 4.05e-8 Cognitive performance; CRC cis rs13392177 0.660 rs12988046 chr2:219073804 A/G cg04731861 chr2:219085781 ARPC2 0.33 6.4 0.33 5.45e-10 Pyoderma gangrenosum in inflammatory bowel disease; CRC cis rs6951245 0.572 rs74791540 chr7:1061913 C/A cg20603222 chr7:1096387 C7orf50;GPR146 -0.7 -5.83 -0.31 1.35e-8 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs1580019 0.885 rs1610141 chr7:32498435 C/T cg14728415 chr7:32535168 LSM5;AVL9 0.44 5.82 0.31 1.36e-8 Cognitive ability; CRC cis rs6076065 0.609 rs3746736 chr20:23424613 T/C cg11657817 chr20:23433608 CST11 0.52 8.55 0.43 4.69e-16 Facial morphology (factor 15, philtrum width); CRC cis rs208520 0.690 rs12192710 chr6:66718137 C/T cg07460842 chr6:66804631 NA 1.06 14.77 0.63 3.26e-38 Exhaled nitric oxide output; CRC cis rs9648716 1.000 rs9648715 chr7:140611845 C/T cg10747023 chr7:140774559 NA 0.47 6.11 0.32 2.74e-9 Type 2 diabetes; CRC cis rs9491140 0.539 rs10872284 chr6:124685928 G/A cg22366943 chr6:124882293 NKAIN2 0.56 8.42 0.42 1.18e-15 Neuroticism; CRC cis rs6502050 0.805 rs56020943 chr17:80105248 C/A cg22110888 chr17:80059540 CCDC57 0.4 6.44 0.33 4.17e-10 Life satisfaction; CRC cis rs1997103 0.798 rs12154964 chr7:55414041 G/A cg17469321 chr7:55412551 NA 0.74 11.54 0.54 4.36e-26 QRS interval (sulfonylurea treatment interaction); CRC cis rs8031584 0.678 rs798127 chr15:31117403 T/C cg08704250 chr15:31115839 NA 0.52 9.32 0.46 1.78e-18 Huntington's disease progression; CRC cis rs35740288 0.539 rs11634553 chr15:86336611 G/A cg20737812 chr15:86336631 KLHL25 -0.43 -7.01 -0.36 1.33e-11 Eosinophil percentage of white cells;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes; CRC cis rs12586317 0.545 rs58342373 chr14:35395269 T/C cg16230307 chr14:35515116 FAM177A1 0.69 8.89 0.44 4.14e-17 Psoriasis; CRC cis rs9914988 0.943 rs2043032 chr17:27136692 A/G cg16670446 chr17:27188758 MIR451;MIR144 0.57 8.02 0.4 1.91e-14 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs1568889 1.000 rs7112860 chr11:28151609 C/A cg06544937 chr11:28130018 METT5D1;KIF18A 0.81 11.56 0.54 3.68e-26 Bipolar disorder; CRC trans rs2303319 0.504 rs58622044 chr2:162596287 A/G cg04551154 chr10:95462393 C10orf4 -0.75 -6.36 -0.33 6.93e-10 Cognitive function; CRC cis rs4713118 0.516 rs7739216 chr6:28079946 G/T cg12963246 chr6:28129442 ZNF389 0.5 5.82 0.31 1.38e-8 Parkinson's disease; CRC cis rs1448094 0.512 rs7313035 chr12:86250100 C/G cg18827107 chr12:86230957 RASSF9 -0.45 -7.49 -0.38 6.6e-13 Major depressive disorder; CRC cis rs763121 0.853 rs5757226 chr22:39070550 T/C cg06022373 chr22:39101656 GTPBP1 0.8 12.62 0.57 4.84e-30 Menopause (age at onset); CRC cis rs1552244 0.882 rs13074282 chr3:10024699 T/G cg16606324 chr3:10149918 C3orf24 0.61 7.98 0.4 2.47e-14 Alzheimer's disease; CRC cis rs10504229 0.906 rs114627636 chr8:58173732 C/T cg02725872 chr8:58115012 NA -0.54 -7.07 -0.36 9.5e-12 Developmental language disorder (linguistic errors); CRC cis rs4332037 0.624 rs11764124 chr7:1891723 C/G cg13880726 chr7:1868755 MAD1L1 -0.43 -5.75 -0.3 2.03e-8 Bipolar disorder; CRC trans rs7615952 0.641 rs2365019 chr3:125808135 T/C cg07211511 chr3:129823064 LOC729375 -0.71 -9.4 -0.46 9.34e-19 Blood pressure (smoking interaction); CRC cis rs140364877 1 rs140364877 chr7:1885178 C/T cg21782813 chr7:2030301 MAD1L1 0.39 6.74 0.35 7.29e-11 Autism spectrum disorder or schizophrenia; CRC cis rs7799006 0.527 rs73039284 chr7:2221583 C/G cg08027265 chr7:2291960 NA -0.37 -5.8 -0.3 1.54e-8 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs17784882 0.524 rs7433300 chr3:47120640 G/A cg27129171 chr3:47204927 SETD2 0.64 9.44 0.46 6.94e-19 QT interval; CRC cis rs9325144 0.555 rs11183215 chr12:38693127 G/A cg26384229 chr12:38710491 ALG10B -0.6 -8.8 -0.44 7.92e-17 Morning vs. evening chronotype; CRC trans rs2303319 0.504 rs58622044 chr2:162596287 A/G cg08132177 chr1:856685 NA -0.68 -6.0 -0.31 5.29e-9 Cognitive function; CRC cis rs1580019 0.844 rs1037322 chr7:32501857 C/T cg06627557 chr7:32535165 LSM5;AVL9 0.84 13.39 0.59 6.1e-33 Cognitive ability; CRC cis rs4728302 0.869 rs7779370 chr7:133595702 T/C cg10665199 chr7:133106180 EXOC4 0.38 5.79 0.3 1.66e-8 Intelligence;Intelligence (multi-trait analysis); CRC cis rs1223397 1.000 rs1223403 chr6:13271812 G/A cg00460589 chr6:13274354 PHACTR1 0.49 6.02 0.31 4.68e-9 Blood pressure; CRC cis rs7517126 1.000 rs7517587 chr1:196840765 A/G cg13682187 chr1:196946512 CFHR5 -0.36 -5.87 -0.31 1.06e-8 Blood protein levels; CRC trans rs7618501 0.602 rs2013208 chr3:50129399 C/T cg21659725 chr3:3221576 CRBN -0.51 -7.77 -0.39 1.01e-13 Intelligence (multi-trait analysis); CRC cis rs4853012 0.838 rs4563249 chr2:74354016 G/T cg20891558 chr2:74357851 NA 0.61 9.6 0.47 2.08e-19 Gestational age at birth (maternal effect); CRC cis rs7666738 0.753 rs7659724 chr4:98944063 C/T cg17366294 chr4:99064904 C4orf37 0.42 7.11 0.36 7.22e-12 Colonoscopy-negative controls vs population controls; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg20385686 chr1:27024451 ARID1A 0.43 7.13 0.37 6.46e-12 Liver disease severity in Alagille syndrome; CRC cis rs13191362 0.935 rs13193473 chr6:162966852 C/A cg23758597 chr6:163146217 PARK2 -0.56 -5.7 -0.3 2.69e-8 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs13161895 0.818 rs114211674 chr5:179484518 A/C cg02702477 chr5:179499311 RNF130 0.69 7.58 0.39 3.54e-13 LDL cholesterol; CRC cis rs1707322 1.000 rs10890359 chr1:46336635 A/G cg06784218 chr1:46089804 CCDC17 0.51 8.92 0.44 3.3e-17 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs8031584 0.560 rs7171208 chr15:31198929 A/G cg19680485 chr15:31195859 MTMR15 0.5 6.95 0.36 1.98e-11 Huntington's disease progression; CRC cis rs6738485 0.552 rs62146770 chr2:106854277 C/T cg15412446 chr2:106886593 NA -0.39 -6.25 -0.33 1.29e-9 Pursuit maintenance gain;Pursuit maintenance gain in psychotic disorders; CRC cis rs9303280 0.776 rs9910826 chr17:38035648 A/G cg00129232 chr17:37814104 STARD3 -0.43 -6.91 -0.36 2.47e-11 Self-reported allergy; CRC cis rs17095355 1.000 rs12570423 chr10:111690942 C/T cg00817464 chr10:111662876 XPNPEP1 -0.6 -7.66 -0.39 2.05e-13 Biliary atresia; CRC cis rs12142240 0.698 rs72677585 chr1:46812374 T/C cg14993813 chr1:46806288 NSUN4 -0.51 -6.48 -0.34 3.28e-10 Menopause (age at onset); CRC cis rs873946 0.586 rs12770021 chr10:134562021 G/A cg18305652 chr10:134549665 INPP5A 0.49 6.18 0.32 1.87e-9 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CRC trans rs3780486 0.801 rs3780495 chr9:33125942 A/C cg04842962 chr6:43655489 MRPS18A 1.15 25.79 0.82 5.51e-81 IgG glycosylation; CRC cis rs7945705 0.902 rs11042152 chr11:9020987 C/T cg14711859 chr11:8959438 ASCL3 -0.42 -6.69 -0.35 9.85e-11 Hemoglobin concentration; CRC cis rs1832871 0.672 rs13437296 chr6:158762819 A/C cg07165851 chr6:158734300 TULP4 0.62 7.89 0.4 4.38e-14 Height; CRC cis rs7618915 0.547 rs13069481 chr3:52666866 C/T cg11645453 chr3:52864694 ITIH4 0.36 6.23 0.32 1.41e-9 Bipolar disorder; CRC cis rs7615952 0.576 rs17523380 chr3:125802874 C/T cg04553112 chr3:125709451 NA -0.49 -6.22 -0.32 1.49e-9 Blood pressure (smoking interaction); CRC cis rs11690935 0.879 rs908671 chr2:172690265 C/G cg13550731 chr2:172543902 DYNC1I2 -1.07 -17.35 -0.69 2.37e-48 Schizophrenia; CRC cis rs1008375 1.000 rs1121090 chr4:17676437 C/G cg04450456 chr4:17643702 FAM184B 0.39 6.22 0.32 1.53e-9 Parasitemia in Tripanosoma cruzi seropositivity; CRC trans rs1814175 0.616 rs1794131 chr11:49904194 A/G cg15704280 chr7:45808275 SEPT13 -0.95 -16.76 -0.68 5.2e-46 Height; CRC cis rs10744422 1.000 rs1587856 chr12:123342229 A/G cg25930673 chr12:123319894 HIP1R -0.6 -6.36 -0.33 6.71e-10 Schizophrenia; CRC cis rs12024301 0.557 rs16828981 chr1:183608658 A/G cg11505048 chr1:183622726 RGL1;APOBEC4 0.81 6.97 0.36 1.75e-11 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs9372498 0.505 rs9489462 chr6:118927855 C/T cg01339444 chr6:118972232 C6orf204 0.52 5.74 0.3 2.11e-8 Diastolic blood pressure; CRC cis rs11628318 0.614 rs3825565 chr14:103060465 G/A cg23461800 chr14:103021989 NA -0.68 -7.83 -0.4 6.62e-14 Platelet count; CRC cis rs208520 0.690 rs1304672 chr6:66847973 A/G cg07460842 chr6:66804631 NA 1.09 14.13 0.61 9.25e-36 Exhaled nitric oxide output; CRC cis rs728616 0.867 rs1983775 chr10:81663575 G/A cg05935833 chr10:81318306 SFTPA2 -0.7 -7.74 -0.39 1.21e-13 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs853679 0.517 rs4711165 chr6:28115184 T/G cg06470822 chr6:28175283 NA 1.03 13.59 0.6 1.04e-33 Depression; CRC cis rs427394 0.664 rs274696 chr5:6732213 A/C cg10857441 chr5:6722123 POLS -0.4 -6.12 -0.32 2.64e-9 Menopause (age at onset); CRC cis rs9487051 0.768 rs2483913 chr6:109521042 G/A cg21918786 chr6:109611834 NA -0.33 -5.72 -0.3 2.33e-8 Reticulocyte fraction of red cells; CRC cis rs4919694 0.572 rs72846714 chr10:104878454 G/A cg04362960 chr10:104952993 NT5C2 0.89 9.29 0.46 2.11e-18 Arsenic metabolism; CRC cis rs7833790 0.963 rs1451997 chr8:82774053 A/T cg17211192 chr8:82754475 SNX16 0.53 6.55 0.34 2.21e-10 Diastolic blood pressure; CRC trans rs208520 0.690 rs12213561 chr6:66705646 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 1.04 14.83 0.63 1.82e-38 Exhaled nitric oxide output; CRC cis rs6570726 0.935 rs366621 chr6:145861275 A/G cg23711669 chr6:146136114 FBXO30 0.7 12.27 0.56 9.25e-29 Lobe attachment (rater-scored or self-reported); CRC cis rs3026101 0.578 rs55747983 chr17:5297742 C/T cg25236894 chr17:5323110 RPAIN;NUP88 0.42 6.79 0.35 5.16e-11 Body mass index; CRC cis rs116095464 0.558 rs12173015 chr5:269967 A/C cg22496380 chr5:211416 CCDC127 0.7 8.71 0.43 1.56e-16 Breast cancer; CRC cis rs9560113 0.597 rs947170 chr13:112241062 G/A cg10483660 chr13:112241077 NA -0.64 -12.89 -0.58 4.84e-31 Menarche (age at onset); CRC cis rs4242434 0.819 rs751680 chr8:22475627 G/A cg03733263 chr8:22462867 KIAA1967 0.91 15.9 0.66 1.21e-42 Exploratory eye movement dysfunction in schizophrenia (cognitive search score); CRC cis rs1215050 0.791 rs165244 chr4:98687889 C/T cg05340658 chr4:99064831 C4orf37 0.45 6.77 0.35 5.98e-11 Waist-to-hip ratio adjusted for body mass index; CRC cis rs1348850 0.632 rs1405718 chr2:178499809 C/T cg02961200 chr2:178257176 LOC100130691;AGPS 0.63 9.19 0.45 4.67e-18 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs7177699 0.557 rs9920493 chr15:79113846 A/C cg15571903 chr15:79123663 NA 0.31 6.13 0.32 2.47e-9 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; CRC cis rs2439831 0.867 rs2614811 chr15:43913487 C/T cg02155558 chr15:43621948 ADAL;LCMT2 0.65 7.25 0.37 3.09e-12 Lung cancer in ever smokers; CRC cis rs66573146 0.572 rs66819208 chr4:6946128 A/G cg00086871 chr4:6988644 TBC1D14 0.84 8.08 0.41 1.22e-14 Granulocyte percentage of myeloid white cells; CRC cis rs2898681 0.519 rs7670068 chr4:53733984 T/G cg26260408 chr4:53727979 RASL11B 0.41 5.74 0.3 2.11e-8 Optic nerve measurement (cup area); CRC cis rs600806 0.821 rs1030522 chr1:109900707 C/G cg23032129 chr1:109941072 SORT1 -0.28 -5.98 -0.31 5.67e-9 Intelligence (multi-trait analysis); CRC cis rs6499129 1.000 rs9922624 chr16:67478976 C/T cg26727032 chr16:67993705 SLC12A4 -0.54 -5.87 -0.31 1.07e-8 Waist-to-hip ratio adjusted for body mass index; CRC cis rs6723226 0.842 rs2754522 chr2:32801257 C/G cg02381751 chr2:32503542 YIPF4 0.61 8.77 0.44 9.63e-17 Intelligence (multi-trait analysis); CRC cis rs12142240 0.698 rs55971480 chr1:46823206 G/T cg14993813 chr1:46806288 NSUN4 -0.49 -6.22 -0.32 1.55e-9 Menopause (age at onset); CRC cis rs889312 0.500 rs832580 chr5:56172646 T/C cg24531977 chr5:56204891 C5orf35 -0.44 -6.69 -0.35 9.73e-11 Breast cancer;Breast cancer (early onset); CRC trans rs8035957 1.000 rs4924273 chr15:38846738 C/G cg02310562 chr12:117348663 FBXW8 -0.5 -6.03 -0.32 4.31e-9 Type 1 diabetes; CRC cis rs7258465 0.931 rs271626 chr19:18627067 C/T cg06462663 chr19:18546047 ISYNA1 -0.5 -7.53 -0.38 4.98e-13 Breast cancer; CRC cis rs6582630 0.555 rs4601853 chr12:38435569 G/A cg26384229 chr12:38710491 ALG10B 0.7 9.79 0.47 5.14e-20 Drug-induced liver injury (flucloxacillin); CRC cis rs6952808 0.760 rs11764960 chr7:1950532 G/A cg00106254 chr7:1943704 MAD1L1 -0.51 -7.32 -0.37 1.87e-12 Bipolar disorder and schizophrenia; CRC cis rs6700896 0.931 rs12021623 chr1:66153586 A/C cg04111102 chr1:66153794 NA 0.35 6.07 0.32 3.47e-9 C-reactive protein;Mean corpuscular volume;Mean corpuscular hemoglobin; CRC cis rs611744 0.647 rs589347 chr8:109253929 T/A cg18478394 chr8:109455254 TTC35 0.39 6.03 0.32 4.51e-9 Dupuytren's disease; CRC trans rs2303319 0.504 rs56009150 chr2:162598582 T/C cg22922770 chr7:98923339 ARPC1A -0.69 -6.19 -0.32 1.77e-9 Cognitive function; CRC cis rs875971 0.545 rs4718348 chr7:65906576 A/G cg11764359 chr7:65958608 NA 0.47 5.9 0.31 9.01e-9 Aortic root size; CRC cis rs10751667 0.643 rs10902238 chr11:944810 G/A ch.11.42038R chr11:967971 AP2A2 0.6 10.27 0.49 1.24e-21 Alzheimer's disease (late onset); CRC cis rs6762 0.748 rs28735718 chr11:839629 A/G cg07691484 chr11:842764 TSPAN4;POLR2L -0.56 -8.33 -0.42 2.21e-15 Mean platelet volume; CRC cis rs2019137 0.936 rs4849169 chr2:113953657 A/C cg07772999 chr2:113993052 PAX8;LOC440839;LOC654433 -0.46 -6.5 -0.34 2.97e-10 Lymphocyte counts; CRC cis rs6558174 0.930 rs1038311 chr8:22489247 T/C cg03733263 chr8:22462867 KIAA1967 0.51 6.79 0.35 5.1e-11 Breast cancer; CRC trans rs7615952 0.546 rs2979350 chr3:125362215 T/C cg21747405 chr11:67723411 NA -0.49 -6.36 -0.33 6.71e-10 Blood pressure (smoking interaction); CRC cis rs7503807 1.000 rs12936076 chr17:78601195 C/T cg09596252 chr17:78655493 RPTOR 0.41 6.33 0.33 7.93e-10 Obesity; CRC cis rs6121246 0.529 rs6060174 chr20:30183538 G/A cg13852791 chr20:30311386 BCL2L1 0.6 8.21 0.41 5.04e-15 Mean corpuscular hemoglobin; CRC cis rs7223966 0.961 rs35844156 chr17:61837568 G/A cg23090583 chr17:61904693 PSMC5;FTSJ3 0.55 6.61 0.34 1.53e-10 Hip circumference adjusted for BMI;Body mass index; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg20014284 chr12:112563241 TRAFD1 0.41 6.02 0.31 4.73e-9 Response to antipsychotic treatment; CRC cis rs2153535 0.504 rs9405393 chr6:8467432 G/T cg21535247 chr6:8435926 SLC35B3 0.5 7.53 0.38 4.89e-13 Motion sickness; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg05454975 chr4:141445769 ELMOD2 0.47 6.6 0.34 1.6e-10 Response to antipsychotic treatment; CRC cis rs9341808 0.683 rs9359409 chr6:80826897 C/G cg08355045 chr6:80787529 NA 0.43 6.9 0.36 2.64e-11 Sitting height ratio; CRC trans rs877282 0.583 rs11253441 chr10:828288 C/T cg22713356 chr15:30763199 NA -0.89 -10.01 -0.48 9.22e-21 Uric acid levels; CRC cis rs6963495 0.818 rs73190187 chr7:105164401 A/T cg02135003 chr7:105160482 PUS7 -0.9 -12.2 -0.56 1.71e-28 Bipolar disorder (body mass index interaction); CRC cis rs6921919 0.609 rs9468365 chr6:28357966 A/T cg21251018 chr6:28226885 NKAPL 0.41 6.24 0.33 1.35e-9 Autism spectrum disorder or schizophrenia; CRC cis rs6738485 0.601 rs7566680 chr2:106851657 G/A cg16099169 chr2:106886729 NA -0.39 -6.7 -0.35 8.85e-11 Pursuit maintenance gain;Pursuit maintenance gain in psychotic disorders; CRC trans rs3780486 0.757 rs10813949 chr9:33123464 G/A cg20290983 chr6:43655470 MRPS18A 1.16 26.82 0.83 8.27e-85 IgG glycosylation; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg09926380 chr3:10052611 LOC401052 0.42 6.34 0.33 7.5e-10 Liver disease severity in Alagille syndrome; CRC cis rs7937682 0.663 rs7116280 chr11:111659111 T/C cg19812747 chr11:111475976 SIK2 0.43 6.11 0.32 2.76e-9 Primary sclerosing cholangitis; CRC cis rs4713118 0.869 rs9461401 chr6:27703291 G/A cg20933634 chr6:27740509 NA 0.58 8.5 0.42 6.74e-16 Parkinson's disease; CRC cis rs2842992 0.958 rs2758318 chr6:160069637 C/G cg11366901 chr6:160182831 ACAT2 0.8 11.44 0.53 9.8e-26 Age-related macular degeneration (geographic atrophy); CRC cis rs875971 0.862 rs2460432 chr7:65554385 C/T cg11764359 chr7:65958608 NA -0.58 -8.85 -0.44 5.59e-17 Aortic root size; CRC cis rs79387448 0.745 rs1403549 chr2:103110745 G/C cg00507830 chr2:103233733 NA 0.51 5.7 0.3 2.73e-8 Gut microbiota (bacterial taxa); CRC cis rs9311474 0.607 rs13076398 chr3:52573096 G/A cg11645453 chr3:52864694 ITIH4 0.33 5.89 0.31 9.65e-9 Electroencephalogram traits; CRC cis rs6951245 1.000 rs80094748 chr7:1103958 G/A cg26224354 chr7:1096374 C7orf50;GPR146 -0.93 -12.07 -0.55 4.89e-28 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs6804368 0.553 rs2888258 chr3:30765115 C/T cg06106510 chr3:30762233 NA 0.37 6.08 0.32 3.4e-9 Blood metabolite levels; CRC cis rs9549367 0.713 rs2480949 chr13:113853149 T/C cg18105134 chr13:113819100 PROZ 0.85 13.44 0.6 3.84e-33 Platelet distribution width; CRC cis rs11252926 0.545 rs11252693 chr10:532139 A/G cg03684893 chr10:554711 DIP2C -0.46 -8.22 -0.41 4.86e-15 Psychosis in Alzheimer's disease; CRC cis rs4588572 0.606 rs4290994 chr5:77742253 C/T cg11547950 chr5:77652471 NA -0.48 -7.03 -0.36 1.17e-11 Triglycerides; CRC cis rs853679 0.760 rs2299029 chr6:28198831 G/A cg15845792 chr6:28175446 NA 0.75 8.1 0.41 1.06e-14 Depression; CRC cis rs6694672 1.000 rs9726778 chr1:197116754 G/C cg13682187 chr1:196946512 CFHR5 0.42 6.65 0.34 1.24e-10 Asthma; CRC cis rs7618915 0.547 rs10865973 chr3:52718154 A/T cg15147215 chr3:52552868 STAB1 -0.62 -10.31 -0.49 8.76e-22 Bipolar disorder; CRC cis rs8105895 0.799 rs10426159 chr19:22267324 G/A cg02657401 chr19:22469223 NA -0.35 -5.75 -0.3 2.05e-8 Body mass index (change over time); CRC cis rs34779708 0.931 rs13377158 chr10:35370465 A/C cg03585969 chr10:35415529 CREM -0.57 -7.65 -0.39 2.22e-13 Inflammatory bowel disease;Crohn's disease; CRC cis rs1153858 1.000 rs12594857 chr15:45667178 A/G cg14582100 chr15:45693742 SPATA5L1 0.28 5.77 0.3 1.88e-8 Homoarginine levels; CRC cis rs1757171 0.542 rs1757186 chr6:37484111 A/G cg01843034 chr6:37503916 NA -0.43 -7.95 -0.4 3.03e-14 Cognitive performance; CRC cis rs2204008 0.811 rs8189445 chr12:38276295 T/C cg26384229 chr12:38710491 ALG10B 0.67 9.01 0.44 1.77e-17 Bladder cancer; CRC cis rs6963495 0.818 rs73190184 chr7:105163736 C/T cg02135003 chr7:105160482 PUS7 -0.9 -12.2 -0.56 1.71e-28 Bipolar disorder (body mass index interaction); CRC cis rs1865760 0.566 rs9467672 chr6:26083904 C/T cg17691542 chr6:26056736 HIST1H1C 0.54 8.16 0.41 7.07e-15 Height; CRC cis rs4563143 0.647 rs117442062 chr19:29256823 A/T cg03161606 chr19:29218774 NA 0.53 6.62 0.34 1.49e-10 Methadone dose in opioid dependence; CRC cis rs4664293 1.000 rs10193402 chr2:160507782 A/G cg08347373 chr2:160653686 CD302 -0.38 -6.24 -0.33 1.38e-9 Monocyte percentage of white cells; CRC cis rs9463078 0.625 rs1360197 chr6:44949630 T/C cg25276700 chr6:44698697 NA -0.23 -5.73 -0.3 2.27e-8 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; CRC cis rs7917772 0.582 rs12779854 chr10:104358474 G/A cg11453585 chr10:104263688 ACTR1A;SUFU -0.83 -14.87 -0.63 1.27e-38 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC cis rs6951245 0.935 rs79067319 chr7:1065548 C/T cg26224354 chr7:1096374 C7orf50;GPR146 -0.86 -10.77 -0.51 2.27e-23 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs6840360 0.517 rs4399967 chr4:152729312 T/A cg09659197 chr4:152720779 NA -0.42 -8.51 -0.42 6.07e-16 Intelligence (multi-trait analysis); CRC cis rs9322193 0.923 rs9322208 chr6:149979683 A/T cg13206674 chr6:150067644 NUP43 0.64 9.53 0.47 3.51e-19 Lung cancer; CRC cis rs9814567 0.727 rs7641798 chr3:134345719 C/T cg06109529 chr3:134205091 CEP63;ANAPC13 -0.62 -8.81 -0.44 7.52e-17 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs10876993 0.928 rs10082911 chr12:58104104 C/A cg18357645 chr12:58087776 OS9 0.6 8.57 0.43 4.21e-16 Celiac disease or Rheumatoid arthritis; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg24666733 chr2:242089739 PPP1R7;PASK 0.44 6.04 0.32 4.1e-9 Anxiety disorder; CRC cis rs1499614 0.901 rs3936 chr7:66126489 C/T cg18252515 chr7:66147081 NA -1.26 -15.13 -0.64 1.25e-39 Gout; CRC cis rs6032067 0.777 rs979641 chr20:43786336 C/T cg10761708 chr20:43804764 PI3 0.48 5.62 0.3 4.06e-8 Blood protein levels; CRC trans rs11039571 0.588 rs10734564 chr11:48160429 A/G cg03929089 chr4:120376271 NA -0.67 -7.27 -0.37 2.56e-12 D-dimer levels; CRC cis rs769267 1.000 rs8103197 chr19:19443466 C/T cg01262667 chr19:19385393 TM6SF2 -0.38 -6.3 -0.33 9.6e-10 Tonsillectomy; CRC cis rs7172809 0.607 rs79590310 chr15:77842095 A/G cg10437265 chr15:77819839 NA -0.36 -5.91 -0.31 8.67e-9 Glucose homeostasis traits; CRC cis rs4972806 0.776 rs2072589 chr2:177042871 C/T cg25347419 chr2:177043501 NA 0.54 8.34 0.42 2e-15 IgG glycosylation; CRC cis rs13394619 1.000 rs2358040 chr2:11731774 G/T cg07314298 chr2:11723111 GREB1 0.49 8.27 0.42 3.25e-15 Endometriosis; CRC cis rs2495707 0.624 rs2489008 chr10:102422934 C/T cg03932441 chr10:102415297 NA -0.33 -5.7 -0.3 2.71e-8 Body mass index; CRC cis rs9487051 0.700 rs7773815 chr6:109602343 A/C cg21918786 chr6:109611834 NA -0.42 -7.4 -0.38 1.13e-12 Reticulocyte fraction of red cells; CRC trans rs7944735 0.671 rs7106731 chr11:48003392 T/G cg03929089 chr4:120376271 NA 0.51 6.74 0.35 6.93e-11 Intraocular pressure; CRC cis rs743757 1.000 rs2073496 chr3:50431142 A/G cg09545109 chr3:50388910 TUSC4;CYB561D2 0.43 6.32 0.33 8.56e-10 Diastolic blood pressure; CRC cis rs6089584 0.888 rs6089623 chr20:60615759 A/G cg12751644 chr20:60527061 NA -0.38 -5.77 -0.3 1.82e-8 Body mass index; CRC cis rs2739330 0.731 rs4822450 chr22:24242887 C/T cg09033563 chr22:24373618 LOC391322 -0.4 -5.63 -0.3 3.79e-8 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs4731207 0.507 rs10954052 chr7:124586811 C/T cg23710748 chr7:124431027 NA -0.39 -6.14 -0.32 2.34e-9 Cutaneous malignant melanoma; CRC trans rs4332037 0.722 rs4719332 chr7:1914681 G/A cg11693508 chr17:37793320 STARD3 0.56 6.95 0.36 2.01e-11 Bipolar disorder; CRC cis rs2440129 0.611 rs1126667 chr17:6902760 C/T cg19536664 chr17:6899085 ALOX12 -0.65 -13.03 -0.58 1.37e-31 Tonsillectomy; CRC cis rs55702914 0.746 rs4850425 chr2:198152786 T/C cg03934865 chr2:198174659 NA -0.44 -7.68 -0.39 1.8e-13 Major depression and alcohol dependence; CRC cis rs597539 0.617 rs686348 chr11:68636996 A/G cg06028808 chr11:68637592 NA 0.41 6.67 0.35 1.07e-10 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs17711722 0.727 rs781151 chr7:65479878 T/C cg11764359 chr7:65958608 NA 0.52 7.67 0.39 2e-13 Calcium levels; CRC cis rs10504229 0.683 rs72649187 chr8:58108320 A/G cg04204079 chr8:58130323 NA -0.46 -5.8 -0.3 1.58e-8 Developmental language disorder (linguistic errors); CRC cis rs6968419 0.755 rs3807981 chr7:115896716 G/A cg02561103 chr7:115862891 TES -0.43 -6.47 -0.34 3.48e-10 Intraocular pressure; CRC cis rs9487051 0.676 rs6929438 chr6:109595506 C/T cg01475377 chr6:109611718 NA -0.37 -6.43 -0.33 4.59e-10 Reticulocyte fraction of red cells; CRC cis rs1223397 0.938 rs35511719 chr6:13282442 T/C cg06879394 chr6:13274151 PHACTR1 0.53 6.32 0.33 8.4e-10 Blood pressure; CRC cis rs853679 0.517 rs9468292 chr6:28095355 G/A cg12963246 chr6:28129442 ZNF389 0.49 5.78 0.3 1.73e-8 Depression; CRC cis rs1018836 0.892 rs1476428 chr8:91555603 G/T cg16814680 chr8:91681699 NA -0.64 -10.45 -0.5 3.03e-22 Ejection fraction in Tripanosoma cruzi seropositivity; CRC cis rs5750830 0.569 rs5750809 chr22:39791491 T/G cg25956985 chr22:39795188 MAP3K7IP1 -0.47 -6.67 -0.35 1.09e-10 Intelligence (multi-trait analysis); CRC cis rs72615157 0.634 rs11762932 chr7:99792666 C/T cg21679810 chr7:100027352 MEPCE;ZCWPW1 -0.59 -6.99 -0.36 1.58e-11 Lung function (FEV1/FVC); CRC cis rs734999 0.545 rs10910105 chr1:2538209 G/A cg18854424 chr1:2615690 NA 0.4 7.67 0.39 2e-13 Ulcerative colitis; CRC cis rs11758351 0.660 rs1997768 chr6:26217728 C/T cg21425842 chr6:26240939 HIST1H4F 0.34 5.73 0.3 2.22e-8 Gout;Renal underexcretion gout; CRC cis rs4954585 0.593 rs12691881 chr2:137029668 A/G cg05194412 chr2:137003533 NA 0.44 6.85 0.35 3.57e-11 Colorectal cancer; CRC trans rs66573146 0.803 rs59809420 chr4:6969928 G/T cg07817883 chr1:32538562 TMEM39B 1.74 14.27 0.62 2.8e-36 Granulocyte percentage of myeloid white cells; CRC cis rs1552244 0.882 rs13099507 chr3:10031603 G/A cg13047869 chr3:10149882 C3orf24 0.51 6.45 0.34 3.96e-10 Alzheimer's disease; CRC cis rs9462846 0.881 rs34498470 chr6:42879551 C/T cg21280719 chr6:42927975 GNMT -0.34 -6.03 -0.32 4.32e-9 Blood protein levels; CRC cis rs13096480 0.583 rs17598137 chr3:49891362 G/T cg01598046 chr3:49894152 TRAIP 0.4 5.92 0.31 8.24e-9 Intelligence (multi-trait analysis); CRC cis rs10751667 0.580 rs10751664 chr11:927077 T/G cg06064525 chr11:970664 AP2A2 -0.33 -6.65 -0.34 1.25e-10 Alzheimer's disease (late onset); CRC cis rs28386778 0.863 rs2727288 chr17:61901197 T/A cg11494091 chr17:61959527 GH2 0.6 10.1 0.49 4.51e-21 Prudent dietary pattern; CRC cis rs11122272 0.735 rs2486728 chr1:231535883 T/G cg06096015 chr1:231504339 EGLN1 0.41 6.11 0.32 2.88e-9 Hemoglobin concentration; CRC cis rs7202877 0.610 rs4536500 chr16:75343197 C/G cg03315344 chr16:75512273 CHST6 -0.49 -5.8 -0.3 1.55e-8 Type 2 diabetes;Type 1 diabetes; CRC cis rs2228479 0.850 rs2302162 chr16:89845287 A/G cg06656553 chr16:89960601 TCF25 -0.71 -5.96 -0.31 6.42e-9 Skin colour saturation; CRC cis rs4919694 1.000 rs11191545 chr10:104829793 C/T cg04362960 chr10:104952993 NT5C2 1.09 10.29 0.49 1.04e-21 Arsenic metabolism; CRC cis rs3820068 0.581 rs6693694 chr1:15980135 G/T cg13390004 chr1:15929781 NA 0.53 7.43 0.38 9.43e-13 Systolic blood pressure; CRC cis rs7044106 0.762 rs4142158 chr9:123410819 C/T cg14255062 chr9:123606675 PSMD5;LOC253039 0.44 6.33 0.33 8.13e-10 Hip circumference adjusted for BMI; CRC cis rs4713118 0.629 rs203887 chr6:28021269 C/T cg03623178 chr6:28175578 NA 0.83 10.78 0.51 2.17e-23 Parkinson's disease; CRC cis rs780096 0.506 rs1647285 chr2:27714511 A/C cg02592271 chr2:27665507 KRTCAP3 -0.3 -7.08 -0.36 8.79e-12 Total body bone mineral density; CRC cis rs9787249 0.957 rs10888958 chr1:40211737 T/C cg19912559 chr1:40204330 PPIE 0.52 7.72 0.39 1.43e-13 Blood protein levels; CRC cis rs3858526 0.834 rs7939099 chr11:5995792 G/A cg13902645 chr11:5959945 NA -0.53 -6.7 -0.35 8.88e-11 DNA methylation (variation); CRC cis rs6912958 0.967 rs6905947 chr6:88161949 C/T cg08069147 chr6:88032118 GJB7;C6orf162 -0.66 -9.98 -0.48 1.17e-20 Monocyte percentage of white cells; CRC cis rs9611565 0.500 rs10775759 chr22:42088158 T/C cg06634786 chr22:41940651 POLR3H 0.49 5.79 0.3 1.64e-8 Vitiligo; CRC cis rs13191362 0.507 rs2849524 chr6:163127070 C/T cg06582575 chr6:163149167 PACRG;PARK2 -0.58 -8.97 -0.44 2.32e-17 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs7312774 0.618 rs7968263 chr12:107330844 C/A cg16260113 chr12:107380972 MTERFD3 0.75 7.51 0.38 5.74e-13 Severe influenza A (H1N1) infection; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg23138817 chr14:105864896 NA 0.39 5.99 0.31 5.4e-9 Intelligence (multi-trait analysis); CRC cis rs763014 0.932 rs2269559 chr16:682297 T/C cg04562611 chr16:615315 C16orf11 0.36 5.98 0.31 5.93e-9 Height; CRC cis rs7618915 0.501 rs7622694 chr3:52663882 G/A cg11645453 chr3:52864694 ITIH4 0.37 6.59 0.34 1.78e-10 Bipolar disorder; CRC cis rs9361491 0.657 rs9343798 chr6:79455282 A/G cg05283184 chr6:79620031 NA -0.38 -5.77 -0.3 1.78e-8 Intelligence (multi-trait analysis); CRC trans rs11088226 0.758 rs2833864 chr21:33888393 A/C cg09050820 chr6:167586206 TCP10L2 0.57 6.31 0.33 8.76e-10 Gastritis; CRC cis rs6502050 0.835 rs66932937 chr17:80116803 G/A cg13198984 chr17:80129470 CCDC57 0.46 8.18 0.41 6.3e-15 Life satisfaction; CRC cis rs910316 1.000 rs2098297 chr14:75619118 G/T cg11812906 chr14:75593930 NEK9 -0.65 -10.62 -0.51 7.32e-23 Height; CRC cis rs4253772 0.513 rs6008700 chr22:46722560 C/T cg24881330 chr22:46731750 TRMU 0.76 9.66 0.47 1.38e-19 LDL cholesterol;Cholesterol, total; CRC cis rs1403694 0.695 rs3821815 chr3:186434262 A/G cg04611788 chr3:186434169 KNG1 -0.61 -9.09 -0.45 9.52e-18 Blood protein levels; CRC trans rs11764590 0.694 rs7797112 chr7:2085165 T/C cg11693508 chr17:37793320 STARD3 0.45 6.1 0.32 2.92e-9 Neuroticism; CRC cis rs2032447 0.531 rs428469 chr6:25898624 G/A cg03264133 chr6:25882463 NA -0.83 -11.41 -0.53 1.19e-25 Intelligence (multi-trait analysis); CRC cis rs13217239 0.646 rs10946888 chr6:26951678 A/G cg12292205 chr6:26970375 C6orf41 0.57 9.4 0.46 9.87e-19 Schizophrenia; CRC trans rs7615952 0.641 rs12495947 chr3:125771698 C/T cg07211511 chr3:129823064 LOC729375 -0.72 -9.7 -0.47 9.79e-20 Blood pressure (smoking interaction); CRC cis rs11758351 0.660 rs1997768 chr6:26217728 C/T cg01420254 chr6:26195488 NA -0.76 -8.77 -0.44 9.69e-17 Gout;Renal underexcretion gout; CRC cis rs6951245 0.638 rs4720486 chr7:1146764 G/A cg20603222 chr7:1096387 C7orf50;GPR146 -0.44 -5.69 -0.3 2.87e-8 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs7429990 0.870 rs13089844 chr3:48140231 G/A cg11946769 chr3:48343235 NME6 -0.44 -5.88 -0.31 1.02e-8 Educational attainment (years of education); CRC trans rs587242 1.000 rs12030271 chr1:96892099 A/G cg10631902 chr5:14652156 NA 0.45 6.9 0.36 2.7e-11 Body mass index (joint analysis main effects and physical activity interaction);Body mass index in physically inactive individuals;Body mass index; CRC cis rs2760061 0.784 rs708116 chr1:228198196 C/A cg01200585 chr1:228362443 C1orf69 0.39 5.73 0.3 2.22e-8 Diastolic blood pressure; CRC trans rs2857891 0.695 rs2468986 chr11:6986027 G/C cg17499358 chr1:24476861 NA 0.3 6.16 0.32 2.07e-9 Response to cytadine analogues (cytosine arabinoside); CRC trans rs11165623 0.792 rs1125358 chr1:96971800 T/C cg10631902 chr5:14652156 NA -0.49 -8.99 -0.44 1.91e-17 Hip circumference;Waist circumference; CRC cis rs1163251 0.837 rs611365 chr1:120242571 C/T cg19096424 chr1:120255104 PHGDH 0.41 5.85 0.31 1.16e-8 Blood metabolite levels; CRC cis rs4665809 0.531 rs12990692 chr2:26464939 C/T cg25036284 chr2:26402008 FAM59B 0.65 8.57 0.43 4.22e-16 Gut microbiome composition (summer); CRC cis rs9488822 0.596 rs13206506 chr6:116324460 A/G cg18764771 chr6:116381957 FRK 0.26 7.07 0.36 9.08e-12 Cholesterol, total;LDL cholesterol; CRC cis rs6840360 0.642 rs2724571 chr4:152376795 T/C cg09659197 chr4:152720779 NA 0.33 6.46 0.34 3.69e-10 Intelligence (multi-trait analysis); CRC cis rs9814567 1.000 rs7427492 chr3:134261654 C/T cg06109529 chr3:134205091 CEP63;ANAPC13 -0.81 -12.36 -0.56 4.47e-29 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs9611565 0.840 rs9607799 chr22:41777558 A/G cg06634786 chr22:41940651 POLR3H -0.64 -7.51 -0.38 5.56e-13 Vitiligo; CRC cis rs933688 1.000 rs2052553 chr5:90729906 C/T cg26981201 chr5:90679533 LOC100129716;ARRDC3 1.06 17.02 0.68 4.77e-47 Smoking behavior; CRC cis rs11785400 0.762 rs7460801 chr8:143730972 C/A cg10596483 chr8:143751796 JRK 0.48 6.49 0.34 3.23e-10 Schizophrenia; CRC cis rs13108904 0.935 rs1620928 chr4:1279124 C/T cg20092199 chr4:1342459 KIAA1530 -0.38 -6.73 -0.35 7.45e-11 Obesity-related traits; CRC cis rs10256972 0.567 rs7782651 chr7:1159895 T/G cg27094323 chr7:1216898 NA -0.37 -5.77 -0.3 1.83e-8 Longevity;Endometriosis; CRC cis rs4665809 0.627 rs7562192 chr2:26469457 C/G cg08067268 chr2:26466485 HADHB;HADHA 0.65 8.56 0.43 4.5e-16 Gut microbiome composition (summer); CRC cis rs7666738 0.830 rs4699574 chr4:98725544 C/T cg05340658 chr4:99064831 C4orf37 0.54 8.0 0.4 2.21e-14 Colonoscopy-negative controls vs population controls; CRC cis rs1862618 0.802 rs4389648 chr5:56103602 A/G cg03609598 chr5:56110824 MAP3K1 -0.83 -10.0 -0.48 9.78e-21 Initial pursuit acceleration; CRC cis rs889398 0.683 rs8047682 chr16:69913446 G/A cg00738113 chr16:70207722 CLEC18C -0.33 -5.7 -0.3 2.68e-8 Body mass index; CRC cis rs798554 0.757 rs1182188 chr7:2869985 T/C cg14863265 chr7:2801509 GNA12 -0.41 -5.78 -0.3 1.78e-8 Height; CRC cis rs951366 0.622 rs11580015 chr1:205676088 G/C cg26354017 chr1:205819088 PM20D1 0.7 10.09 0.49 4.75e-21 Menarche (age at onset); CRC cis rs1552244 0.810 rs4019706 chr3:10112862 G/A cg10729496 chr3:10149963 C3orf24 0.5 6.74 0.35 7.23e-11 Alzheimer's disease; CRC trans rs2303319 0.504 rs56965753 chr2:162597251 A/G cg22988483 chr14:93581567 ITPK1 -0.66 -6.07 -0.32 3.52e-9 Cognitive function; CRC cis rs12477438 0.765 rs13390672 chr2:99589829 C/T cg26064155 chr2:99771622 LIPT1;TSGA10 -0.63 -8.56 -0.43 4.4e-16 Chronic sinus infection; CRC cis rs801193 0.839 rs12534943 chr7:66070520 A/G cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.42 -6.22 -0.32 1.55e-9 Aortic root size; CRC cis rs1983170 0.736 rs12127718 chr1:91997490 A/T cg21854759 chr1:92012499 NA 0.5 5.84 0.31 1.28e-8 Eosinophil percentage of white cells; CRC cis rs116248771 0.549 rs1548013 chr3:158431070 C/T cg16708174 chr3:158430962 RARRES1 0.45 6.05 0.32 4.04e-9 diarrhoeal disease at age 2; CRC cis rs2739330 0.731 rs5751792 chr22:24401542 G/A cg24846343 chr22:24311635 DDTL 0.66 10.84 0.51 1.29e-23 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs7223966 0.960 rs2854222 chr17:61939015 C/T cg23903597 chr17:61704154 MAP3K3 -0.45 -6.22 -0.32 1.48e-9 Hip circumference adjusted for BMI;Body mass index; CRC cis rs597583 0.664 rs10892133 chr11:117383694 C/T cg27161313 chr11:117392002 DSCAML1 -0.45 -5.8 -0.3 1.58e-8 Putamen volume; CRC cis rs4423214 0.625 rs78685409 chr11:71137383 T/C cg05163923 chr11:71159392 DHCR7 -0.66 -7.92 -0.4 3.72e-14 Vitamin D levels; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg24497270 chr17:42401753 SLC25A39 0.46 6.46 0.34 3.75e-10 Anxiety disorder; CRC trans rs11098499 0.657 rs7664458 chr4:120371967 A/G cg25214090 chr10:38739885 LOC399744 0.66 10.47 0.5 2.41e-22 Corneal astigmatism; CRC cis rs6545883 0.894 rs6734628 chr2:61451260 T/C cg15711740 chr2:61764176 XPO1 0.43 5.78 0.3 1.72e-8 Tuberculosis; CRC cis rs7786808 0.741 rs35059736 chr7:158224692 C/T cg15440763 chr7:158190612 PTPRN2 0.41 6.44 0.33 4.16e-10 Obesity-related traits; CRC cis rs4757319 0.515 rs6486237 chr11:15334740 G/A cg03245590 chr11:15329459 NA -0.53 -9.42 -0.46 8.16e-19 Breast cancer; CRC cis rs9322193 0.962 rs9478848 chr6:150146216 G/T cg05861140 chr6:150128134 PCMT1 -0.41 -6.63 -0.34 1.35e-10 Lung cancer; CRC cis rs4561483 0.799 rs33635 chr16:11991944 C/T cg08843971 chr16:11963173 GSPT1 -0.6 -8.96 -0.44 2.5e-17 Testicular germ cell tumor; CRC cis rs2932538 1.000 rs2932538 chr1:113216543 A/G cg22162597 chr1:113214053 CAPZA1 -0.68 -9.67 -0.47 1.26e-19 Systolic blood pressure;Diastolic blood pressure;Hypertension;Blood pressure; CRC trans rs7180079 0.686 rs11071801 chr15:64883884 C/T cg02770814 chr5:137368293 FAM13B -0.6 -6.05 -0.32 4.02e-9 Monocyte count; CRC cis rs734999 0.588 rs4648562 chr1:2535613 C/A cg20673091 chr1:2541236 MMEL1 0.37 6.02 0.31 4.78e-9 Ulcerative colitis; CRC cis rs2011503 1.000 rs34067609 chr19:19653524 G/A cg11584989 chr19:19387371 SF4 0.58 6.39 0.33 5.61e-10 Bipolar disorder; CRC cis rs853679 0.517 rs56364346 chr6:28050762 T/G cg02631126 chr6:28058918 ZSCAN12L1 0.29 6.09 0.32 3.1e-9 Depression; CRC cis rs11122272 0.735 rs2491410 chr1:231532287 C/T cg06096015 chr1:231504339 EGLN1 0.39 5.84 0.31 1.26e-8 Hemoglobin concentration; CRC cis rs9322193 0.923 rs3798761 chr6:150004779 A/G cg05861140 chr6:150128134 PCMT1 -0.36 -5.85 -0.31 1.18e-8 Lung cancer; CRC trans rs6703335 0.870 rs10803142 chr1:243598234 A/G cg14909376 chr20:43588988 TOMM34 0.42 6.01 0.31 4.83e-9 Schizophrenia;Schizophrenia, schizoaffective disorder or bipolar disorder; CRC cis rs2404602 0.669 rs17464903 chr15:77195486 A/G cg22467129 chr15:76604101 ETFA -0.39 -6.2 -0.32 1.65e-9 Blood metabolite levels; CRC cis rs4648845 0.777 rs2477686 chr1:2392648 C/G cg11214544 chr1:2391121 NA -0.48 -7.79 -0.39 8.91e-14 Schizophrenia; CRC cis rs6502050 0.799 rs7502524 chr17:80107261 C/T cg02741985 chr17:80059408 CCDC57 0.43 7.15 0.37 5.66e-12 Life satisfaction; CRC cis rs2180341 0.920 rs9398836 chr6:127576497 T/G cg27446573 chr6:127587934 RNF146 0.98 14.61 0.63 1.29e-37 Breast cancer; CRC cis rs11758351 1.000 rs74363821 chr6:26189524 G/C cg22723502 chr6:26240528 HIST1H4F -0.37 -5.73 -0.3 2.31e-8 Gout;Renal underexcretion gout; CRC cis rs10638925 1 rs10638925 chr3:194119749 C/CCATAAA cg00834899 chr3:194121120 GP5 0.62 10.6 0.5 8.85e-23 Platelet distribution width; CRC cis rs7312933 1.000 rs11181328 chr12:42504679 T/G cg17420585 chr12:42539391 GXYLT1 -0.43 -6.24 -0.33 1.32e-9 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CRC trans rs3960554 0.932 rs11975745 chr7:75843524 T/C cg19862616 chr7:65841803 NCRNA00174 0.71 7.9 0.4 4.14e-14 Eotaxin levels; CRC cis rs9486715 0.867 rs9384602 chr6:96919561 G/A cg18709589 chr6:96969512 KIAA0776 0.48 7.16 0.37 5.32e-12 Headache; CRC cis rs72799341 0.706 rs11865499 chr16:31132250 A/G cg02466173 chr16:30829666 NA -0.42 -5.67 -0.3 3.17e-8 Diastolic blood pressure; CRC cis rs2346177 0.519 rs13003074 chr2:46671420 A/T cg02822958 chr2:46747628 ATP6V1E2 -0.41 -6.09 -0.32 3.18e-9 HDL cholesterol; CRC cis rs728616 0.867 rs17886286 chr10:81703852 C/G cg05935833 chr10:81318306 SFTPA2 -0.72 -7.88 -0.4 4.76e-14 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs9467711 0.606 rs67234939 chr6:26530419 A/G cg16898833 chr6:26189333 HIST1H4D 0.82 7.17 0.37 5.05e-12 Autism spectrum disorder or schizophrenia; CRC cis rs10479542 0.896 rs4701131 chr5:178982446 A/G cg21226059 chr5:178986404 RUFY1 0.42 7.79 0.39 8.85e-14 Lung cancer; CRC cis rs12024301 0.557 rs11804313 chr1:183647803 T/C cg11505048 chr1:183622726 RGL1;APOBEC4 0.71 6.24 0.33 1.33e-9 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs758324 0.812 rs30159 chr5:131306535 T/C cg25547332 chr5:131281432 NA -0.36 -5.78 -0.3 1.74e-8 Alzheimer's disease in APOE e4- carriers; CRC cis rs644799 1.000 rs560854 chr11:95584905 G/A cg03916912 chr11:95522834 CEP57;FAM76B 0.94 17.83 0.7 2.97e-50 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs4481887 0.504 rs4390205 chr1:248358273 C/A cg00666640 chr1:248458726 OR2T12 0.44 7.07 0.36 9.39e-12 Common traits (Other); CRC cis rs28386778 0.897 rs2665844 chr17:61874455 A/G cg06601766 chr17:61851465 DDX42;CCDC47 0.45 6.14 0.32 2.4e-9 Prudent dietary pattern; CRC trans rs637571 0.512 rs660118 chr11:65735174 G/C cg17712092 chr4:129076599 LARP1B 0.73 11.68 0.54 1.33e-26 Eosinophil percentage of white cells; CRC cis rs9457247 0.534 rs4710149 chr6:167386346 T/C cg23791538 chr6:167370224 RNASET2 0.47 7.58 0.39 3.67e-13 Crohn's disease; CRC cis rs870825 0.616 rs12498890 chr4:185636096 C/G cg04058563 chr4:185651563 MLF1IP -0.75 -9.35 -0.46 1.34e-18 Blood protein levels; CRC cis rs4282054 0.631 rs13081155 chr3:52732429 A/G cg11645453 chr3:52864694 ITIH4 0.33 6.01 0.31 4.79e-9 Cognitive function; CRC cis rs2239547 0.657 rs2071040 chr3:52864860 A/G cg11645453 chr3:52864694 ITIH4 0.61 10.32 0.49 8.14e-22 Schizophrenia; CRC cis rs1005277 0.579 rs2474584 chr10:38416389 C/T cg25427524 chr10:38739819 LOC399744 -0.77 -13.56 -0.6 1.36e-33 Extrinsic epigenetic age acceleration; CRC cis rs939584 0.935 rs7579427 chr2:631183 C/A cg03610516 chr2:642275 NA 0.43 5.61 0.3 4.36e-8 Body mass index; CRC cis rs28735056 0.967 rs498541 chr18:77589655 G/A cg20368463 chr18:77673604 PQLC1 -0.54 -8.44 -0.42 9.91e-16 Schizophrenia; CRC cis rs2380220 0.935 rs7748857 chr6:96001887 A/G cg15832292 chr6:96025679 MANEA 0.56 5.73 0.3 2.25e-8 Behavioural disinhibition (generation interaction); CRC cis rs938554 0.779 rs9998811 chr4:9966477 G/A cg00071950 chr4:10020882 SLC2A9 -0.44 -6.04 -0.32 4.26e-9 Blood metabolite levels; CRC trans rs7944735 0.517 rs1827503 chr11:48225115 G/T cg15704280 chr7:45808275 SEPT13 0.68 6.56 0.34 2.07e-10 Intraocular pressure; CRC cis rs372883 0.648 rs1153288 chr21:30686091 A/G cg24692254 chr21:30365293 RNF160 0.58 8.39 0.42 1.44e-15 Pancreatic cancer; CRC cis rs2576037 1.000 rs2576037 chr18:44585420 C/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 -0.51 -8.21 -0.41 5e-15 Personality dimensions; CRC cis rs698833 0.886 rs1056865 chr2:44546741 A/G cg04920474 chr2:44395004 PPM1B 0.41 5.91 0.31 8.49e-9 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; CRC cis rs9796 0.870 rs2306083 chr15:41347658 C/T cg18705301 chr15:41695430 NDUFAF1 -0.34 -5.71 -0.3 2.54e-8 Menopause (age at onset); CRC trans rs459571 0.959 rs460888 chr9:136913123 C/G cg09836344 chr4:1243392 C4orf42;CTBP1 -0.8 -11.1 -0.52 1.61e-24 Platelet distribution width; CRC cis rs11997175 0.549 rs4349945 chr8:33654323 T/C cg04338863 chr8:33670619 NA 0.39 6.88 0.35 2.97e-11 Body mass index; CRC cis rs13191362 1.000 rs13210412 chr6:163019478 T/C cg23758597 chr6:163146217 PARK2 -0.54 -6.18 -0.32 1.93e-9 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs11148252 0.574 rs7139495 chr13:53283318 A/G cg02158880 chr13:53174818 NA 0.54 8.56 0.43 4.31e-16 Lewy body disease; CRC cis rs9660992 0.710 rs1180721 chr1:205232696 T/C cg21643547 chr1:205240462 TMCC2 -0.45 -7.26 -0.37 2.85e-12 Mean corpuscular volume;Mean platelet volume; CRC cis rs644799 1.000 rs1784135 chr11:95531748 G/A cg25622487 chr11:95524042 FAM76B;CEP57 0.76 11.87 0.55 2.74e-27 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs77633900 0.614 rs2585730 chr15:76989344 A/G cg21673338 chr15:77095150 SCAPER -0.73 -7.3 -0.37 2.12e-12 Non-glioblastoma glioma;Glioma; CRC cis rs1348850 0.651 rs1901826 chr2:178225266 G/A cg02961200 chr2:178257176 LOC100130691;AGPS 0.46 6.59 0.34 1.78e-10 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC trans rs12478296 0.681 rs6598999 chr2:242994405 C/A cg18288967 chr1:45987694 PRDX1 0.64 7.81 0.4 7.56e-14 Obesity-related traits; CRC trans rs8002861 0.713 rs7339417 chr13:44413496 A/T cg17145862 chr1:211918768 LPGAT1 0.58 10.01 0.48 9.19e-21 Leprosy; CRC cis rs155076 0.702 rs482731 chr13:21846075 G/A cg21970626 chr13:21893289 NA 0.42 5.62 0.3 4.06e-8 White matter hyperintensity burden; CRC cis rs4664293 0.647 rs1863686 chr2:160504049 C/T cg08347373 chr2:160653686 CD302 -0.38 -6.55 -0.34 2.16e-10 Monocyte percentage of white cells; CRC cis rs1003719 0.713 rs7277150 chr21:38490006 T/C cg10648535 chr21:38446584 PIGP;TTC3 0.53 7.49 0.38 6.44e-13 Eye color traits; CRC trans rs61931739 0.500 rs7965679 chr12:34542494 T/C cg13010199 chr12:38710504 ALG10B 0.45 6.52 0.34 2.65e-10 Morning vs. evening chronotype; CRC trans rs7726839 0.574 rs72707007 chr5:661856 T/C cg11887960 chr12:57824829 NA 0.64 7.14 0.37 5.9e-12 Obesity-related traits; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg22833292 chr11:64126806 RPS6KA4 0.47 6.99 0.36 1.55e-11 Intelligence (multi-trait analysis); CRC cis rs875971 0.628 rs6974355 chr7:65841981 A/G cg00343986 chr7:65444356 GUSB 0.47 6.69 0.35 9.4e-11 Aortic root size; CRC cis rs8067545 0.611 rs6587219 chr17:20034531 T/G cg13482628 chr17:19912719 NA 0.44 6.79 0.35 5.15e-11 Schizophrenia; CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg02065795 chr15:64673455 KIAA0101 -0.51 -6.12 -0.32 2.62e-9 Diisocyanate-induced asthma; CRC cis rs4795419 1 rs4795419 chr17:38166003 G/A cg17344932 chr17:38183730 MED24;SNORD124 -0.45 -7.03 -0.36 1.21e-11 Monocyte percentage of white cells; CRC cis rs873946 0.586 rs12776770 chr10:134564831 T/C cg18305652 chr10:134549665 INPP5A 0.54 7.47 0.38 7.43e-13 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CRC cis rs2495707 0.624 rs2489006 chr10:102419893 G/A cg13834844 chr10:102415320 NA -0.36 -5.96 -0.31 6.6e-9 Body mass index; CRC cis rs35110281 0.627 rs11701746 chr21:44975137 C/T cg04455712 chr21:45112962 RRP1B 0.38 7.17 0.37 5.05e-12 Mean corpuscular volume; CRC cis rs2404602 1.000 rs1117367 chr15:76872330 A/C cg22467129 chr15:76604101 ETFA -0.38 -6.39 -0.33 5.71e-10 Blood metabolite levels; CRC cis rs7552404 0.731 rs2029683 chr1:76341643 T/G cg03433033 chr1:76189801 ACADM -0.66 -8.28 -0.42 3.15e-15 Blood metabolite levels;Acylcarnitine levels; CRC cis rs938554 0.571 rs7696092 chr4:10025320 C/A cg11266682 chr4:10021025 SLC2A9 0.43 7.18 0.37 4.76e-12 Blood metabolite levels; CRC cis rs68170813 0.559 rs1002935 chr7:106832361 G/A cg02696742 chr7:106810147 HBP1 -0.64 -7.24 -0.37 3.29e-12 Coronary artery disease; CRC cis rs4243830 0.737 rs56036909 chr1:6608503 C/T cg05709478 chr1:6581295 PLEKHG5 0.66 7.36 0.38 1.47e-12 Body mass index; CRC cis rs4862750 0.957 rs1030381 chr4:187903568 G/C cg11301795 chr4:187892539 NA -0.89 -19.78 -0.74 6.16e-58 Lobe attachment (rater-scored or self-reported); CRC cis rs4319547 0.695 rs10846699 chr12:122853073 A/G cg23029597 chr12:123009494 RSRC2 0.57 7.4 0.38 1.15e-12 Body mass index; CRC cis rs10140922 0.966 rs10135277 chr14:35823231 A/G cg07166546 chr14:35805898 NA 0.29 5.9 0.31 9.05e-9 Hip circumference adjusted for BMI; CRC cis rs3796352 1.000 rs71301814 chr3:53117663 G/A cg07884673 chr3:53033167 SFMBT1 0.76 6.17 0.32 1.98e-9 Immune reponse to smallpox (secreted IL-2); CRC cis rs4237845 0.537 rs11172367 chr12:58272486 T/G cg00677455 chr12:58241039 CTDSP2 0.78 11.47 0.53 7.55e-26 Intelligence (multi-trait analysis); CRC cis rs7772486 0.846 rs6908063 chr6:146403618 T/C cg13319975 chr6:146136371 FBXO30 -0.39 -6.05 -0.32 3.87e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs3857067 0.772 rs4438731 chr4:95091384 A/G cg11021082 chr4:95130006 SMARCAD1 -0.5 -7.73 -0.39 1.28e-13 QT interval; CRC cis rs9896933 0.561 rs2264375 chr17:80692709 T/A cg15664640 chr17:80829946 TBCD -0.56 -6.11 -0.32 2.87e-9 Bone mineral accretion in asthma (oral corticosteroid dose interaction); CRC cis rs4689592 0.503 rs56099074 chr4:7071259 A/G cg06697600 chr4:7070879 GRPEL1 0.56 7.39 0.38 1.19e-12 Monocyte percentage of white cells; CRC cis rs912057 0.671 rs1294425 chr6:6744292 G/A cg06612196 chr6:6737390 NA 0.54 8.59 0.43 3.49e-16 Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction); CRC cis rs13118159 0.550 rs1137789 chr4:1381798 A/G cg02475777 chr4:1388615 CRIPAK 0.52 6.71 0.35 8.42e-11 Longevity; CRC cis rs10504229 0.683 rs59528137 chr8:58138565 C/T cg21724239 chr8:58056113 NA 0.76 9.41 0.46 8.87e-19 Developmental language disorder (linguistic errors); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg20774722 chr17:19551893 ALDH3A2 0.4 7.05 0.36 1.05e-11 Liver disease severity in Alagille syndrome; CRC cis rs1215050 0.755 rs783958 chr4:98893836 A/T cg05340658 chr4:99064831 C4orf37 -0.48 -7.2 -0.37 4.23e-12 Waist-to-hip ratio adjusted for body mass index; CRC cis rs3106136 0.872 rs2059606 chr4:95255278 C/T cg11021082 chr4:95130006 SMARCAD1 0.39 6.04 0.32 4.2e-9 Capecitabine sensitivity; CRC cis rs2439831 0.850 rs10163054 chr15:44047638 G/T cg02155558 chr15:43621948 ADAL;LCMT2 0.69 7.61 0.39 2.95e-13 Lung cancer in ever smokers; CRC cis rs7412746 0.611 rs4970985 chr1:150887442 C/T cg17724175 chr1:150552817 MCL1 -0.39 -6.01 -0.31 4.94e-9 Melanoma; CRC cis rs11758351 0.925 rs78932312 chr6:26194869 A/G cg01420254 chr6:26195488 NA 0.83 8.68 0.43 1.82e-16 Gout;Renal underexcretion gout; CRC cis rs919433 1.000 rs919433 chr2:198166565 G/A cg20885578 chr2:198174922 NA -0.41 -6.94 -0.36 2.16e-11 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC cis rs11212617 1.000 rs227087 chr11:108244114 T/C cg14761454 chr11:108092087 ATM;NPAT 0.44 6.76 0.35 6.12e-11 Response to metformin in type 2 diabetes (glycemic); CRC cis rs9443645 0.901 rs55755815 chr6:79607121 G/T cg11833968 chr6:79620685 NA -0.37 -6.48 -0.34 3.34e-10 Intelligence (multi-trait analysis); CRC cis rs11785693 0.865 rs7815144 chr8:4970788 G/T cg26367366 chr8:4980734 NA -0.68 -9.02 -0.45 1.63e-17 Neuroticism (multi-trait analysis);Neuroticism; CRC cis rs4803468 1.000 rs11670757 chr19:41913431 G/T cg09537434 chr19:41945824 ATP5SL -0.92 -18.27 -0.71 5.69e-52 Height; CRC cis rs8180040 0.783 rs11710121 chr3:47351501 T/G cg02527881 chr3:46936655 PTH1R 0.33 5.75 0.3 2.04e-8 Colorectal cancer; CRC cis rs6963495 0.556 rs818481 chr7:105158467 G/C cg02135003 chr7:105160482 PUS7 -0.52 -8.11 -0.41 1.01e-14 Bipolar disorder (body mass index interaction); CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg09031165 chr17:17586474 RAI1 0.5 6.42 0.33 4.89e-10 Thyroid stimulating hormone; CRC cis rs4713118 0.621 rs4713133 chr6:28034041 T/C cg06470822 chr6:28175283 NA 0.94 12.8 0.58 1.0500000000000001e-30 Parkinson's disease; CRC trans rs3733585 0.648 rs13125029 chr4:9982029 A/G cg26043149 chr18:55253948 FECH 0.49 7.49 0.38 6.48e-13 Cleft plate (environmental tobacco smoke interaction); CRC cis rs4662945 0.688 rs12993231 chr2:130206377 A/G cg05962382 chr2:130345044 NA -0.33 -5.65 -0.3 3.55e-8 Response to cytidine analogues (gemcitabine); CRC cis rs2243480 1.000 rs1546059 chr7:65654709 C/A cg25985355 chr7:65971099 NA 0.54 6.13 0.32 2.57e-9 Diabetic kidney disease; CRC cis rs11958404 0.860 rs72818114 chr5:157440207 A/C cg05962755 chr5:157440814 NA 0.96 12.14 0.56 2.72e-28 IgG glycosylation; CRC cis rs17376456 0.825 rs10078941 chr5:93279029 C/T cg25358565 chr5:93447407 FAM172A 1.1 10.9 0.52 7.71e-24 Diabetic retinopathy; CRC cis rs4665809 0.818 rs35413760 chr2:26267137 C/A cg04944784 chr2:26401820 FAM59B 0.66 7.29 0.37 2.38e-12 Gut microbiome composition (summer); CRC cis rs12477438 0.798 rs4622780 chr2:99631760 C/G cg26064155 chr2:99771622 LIPT1;TSGA10 -0.73 -10.18 -0.49 2.41e-21 Chronic sinus infection; CRC cis rs11098499 0.954 rs17005535 chr4:120411562 C/T cg09307838 chr4:120376055 NA 0.7 11.02 0.52 2.99e-24 Corneal astigmatism; CRC cis rs11997175 0.624 rs7001604 chr8:33680979 T/C ch.8.33884649F chr8:33765107 NA 0.43 6.12 0.32 2.65e-9 Body mass index; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg10005894 chr3:186649165 ST6GAL1 0.43 5.99 0.31 5.44e-9 Intelligence (multi-trait analysis); CRC cis rs7781266 0.741 rs62469960 chr7:133141695 A/G cg03336402 chr7:133662267 EXOC4 0.49 5.89 0.31 9.55e-9 Educational attainment (college completion); CRC cis rs4423214 0.840 rs1619577 chr11:71181485 C/T cg05163923 chr11:71159392 DHCR7 -0.64 -7.69 -0.39 1.71e-13 Vitamin D levels; CRC cis rs4466137 0.953 rs7735476 chr5:83015140 G/C cg15083037 chr5:83017644 HAPLN1 -0.53 -6.91 -0.36 2.45e-11 Prostate cancer; CRC cis rs9796 0.621 rs537244 chr15:41469313 G/T cg18705301 chr15:41695430 NDUFAF1 0.42 6.88 0.35 2.99e-11 Menopause (age at onset); CRC cis rs7647973 0.677 rs11130211 chr3:49645209 C/T cg13072238 chr3:49761600 GMPPB -0.51 -5.81 -0.3 1.5e-8 Menarche (age at onset); CRC cis rs4481887 0.927 rs7555310 chr1:248487638 A/G cg00666640 chr1:248458726 OR2T12 0.46 7.93 0.4 3.55e-14 Common traits (Other); CRC cis rs2836974 0.897 rs2836944 chr21:40593539 G/A cg11644478 chr21:40555479 PSMG1 0.79 11.99 0.55 1.01e-27 Cognitive function; CRC cis rs7786808 0.530 rs7785656 chr7:158184164 C/G cg15440763 chr7:158190612 PTPRN2 0.47 7.63 0.39 2.52e-13 Obesity-related traits; CRC cis rs116095464 0.558 rs55664502 chr5:270485 T/C cg22496380 chr5:211416 CCDC127 -0.86 -10.25 -0.49 1.41e-21 Breast cancer; CRC cis rs12291225 0.679 rs4757245 chr11:14297872 A/C cg19336497 chr11:14380999 RRAS2 -0.52 -8.62 -0.43 2.96e-16 Sense of smell; CRC cis rs2760061 0.545 rs1636196 chr1:228204030 A/G cg02753203 chr1:228287806 NA 0.88 13.1 0.59 7.43e-32 Diastolic blood pressure; CRC cis rs7580658 0.963 rs2090574 chr2:128131391 C/A cg09760422 chr2:128146352 NA -0.36 -6.9 -0.36 2.6e-11 Protein C levels; CRC cis rs11148252 0.774 rs9536066 chr13:52983981 A/G cg12458913 chr13:53173898 NA 0.56 8.82 0.44 7.02e-17 Lewy body disease; CRC cis rs11628318 0.617 rs11626481 chr14:103086356 A/G cg12046867 chr14:103022105 NA -0.73 -8.67 -0.43 2.07e-16 Platelet count; CRC cis rs796364 0.906 rs281784 chr2:200749749 T/A cg23649088 chr2:200775458 C2orf69 0.53 5.75 0.3 2.01e-8 Schizophrenia; CRC cis rs12545109 0.800 rs1437278 chr8:57357024 T/C cg09654669 chr8:57350985 NA -0.44 -5.93 -0.31 7.85e-9 Obesity-related traits; CRC cis rs1862618 0.754 rs252899 chr5:56188569 G/C cg03609598 chr5:56110824 MAP3K1 -0.87 -10.18 -0.49 2.47e-21 Initial pursuit acceleration; CRC cis rs6951245 0.938 rs112425403 chr7:1071531 A/G cg07217954 chr7:1067459 C7orf50 0.55 5.68 0.3 3.04e-8 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs12476592 0.543 rs2604615 chr2:63898428 T/C cg10828910 chr2:63850056 LOC388955 0.5 6.26 0.33 1.23e-9 Childhood ear infection; CRC cis rs8062405 1.000 rs11861174 chr16:28871989 A/G cg08761264 chr16:28874980 SH2B1 -0.44 -5.83 -0.31 1.33e-8 Cognitive ability (multi-trait analysis);Cognitive ability; CRC cis rs66887589 0.616 rs6843509 chr4:120220196 G/A cg09307838 chr4:120376055 NA 0.55 8.44 0.42 1.06e-15 Diastolic blood pressure; CRC cis rs72634258 0.945 rs12757968 chr1:8106201 A/G cg00042356 chr1:8021962 PARK7 0.67 7.13 0.37 6.42e-12 Inflammatory bowel disease; CRC cis rs4654899 0.758 rs6690574 chr1:21504279 G/A cg02927042 chr1:21476669 EIF4G3 -0.4 -6.38 -0.33 5.86e-10 Superior frontal gyrus grey matter volume; CRC cis rs1371867 0.513 rs1542812 chr8:101207064 G/A cg06002616 chr8:101225028 SPAG1 0.35 6.19 0.32 1.79e-9 Atrioventricular conduction; CRC cis rs6860806 0.531 rs272888 chr5:131665423 T/C cg04518342 chr5:131593106 PDLIM4 0.42 6.88 0.35 3.04e-11 Breast cancer; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg02139671 chr12:123237174 DENR 0.49 6.22 0.32 1.51e-9 Thyroid stimulating hormone; CRC cis rs7312933 0.558 rs55702525 chr12:42814309 T/C cg11827402 chr12:42719852 PPHLN1;ZCRB1 -0.66 -9.76 -0.47 6.03e-20 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg00006032 chr14:66974439 GPHN 0.51 6.64 0.34 1.29e-10 Thyroid stimulating hormone; CRC cis rs6502050 0.835 rs4789731 chr17:80145904 C/T cg22110888 chr17:80059540 CCDC57 0.4 6.32 0.33 8.64e-10 Life satisfaction; CRC cis rs11971779 0.680 rs6963867 chr7:139059964 T/G cg23387468 chr7:139079360 LUC7L2 0.41 7.04 0.36 1.14e-11 Diisocyanate-induced asthma; CRC cis rs6831352 0.959 rs1139490 chr4:100045141 C/T cg12011299 chr4:100065546 ADH4 0.54 11.64 0.54 1.78e-26 Alcohol dependence; CRC cis rs4604732 0.603 rs10802512 chr1:247633730 G/T cg02104434 chr1:247694406 LOC148824;OR2C3 0.41 6.61 0.34 1.56e-10 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CRC cis rs6952808 1.000 rs6957894 chr7:1887362 G/A cg22963979 chr7:1858916 MAD1L1 -0.58 -9.17 -0.45 5.17e-18 Bipolar disorder and schizophrenia; CRC cis rs9894429 0.527 rs7405469 chr17:79566596 G/C cg18240062 chr17:79603768 NPLOC4 -0.42 -5.69 -0.3 2.81e-8 Eye color traits; CRC cis rs7412746 0.634 rs7521592 chr1:150821691 A/C cg10589385 chr1:150898437 SETDB1 0.33 6.79 0.35 5.17e-11 Melanoma; CRC cis rs34779708 0.966 rs35814343 chr10:35427714 G/T cg03585969 chr10:35415529 CREM 0.66 8.68 0.43 1.88e-16 Inflammatory bowel disease;Crohn's disease; CRC cis rs875971 0.862 rs778736 chr7:65813848 C/T cg18252515 chr7:66147081 NA -0.42 -5.93 -0.31 7.79e-9 Aortic root size; CRC cis rs7223966 1.000 rs7222060 chr17:61868279 C/T cg23090583 chr17:61904693 PSMC5;FTSJ3 0.51 6.27 0.33 1.16e-9 Hip circumference adjusted for BMI;Body mass index; CRC cis rs17234274 0.622 rs10833981 chr11:23232602 C/A cg05245346 chr11:23248277 NA 0.36 5.84 0.31 1.23e-8 Cancer; CRC cis rs34172651 0.517 rs11642954 chr16:24824248 G/A cg00339695 chr16:24857497 SLC5A11 0.43 8.85 0.44 5.67e-17 Intelligence (multi-trait analysis); CRC cis rs17376456 0.877 rs66696214 chr5:93424533 G/A cg25358565 chr5:93447407 FAM172A 1.02 10.38 0.5 4.9e-22 Diabetic retinopathy; CRC cis rs9868809 0.881 rs2286652 chr3:48689192 G/A cg00383909 chr3:49044727 WDR6 0.88 8.82 0.44 7.02e-17 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; CRC cis rs853679 0.760 rs11962305 chr6:28199937 G/C cg02683197 chr6:28174875 NA 0.67 6.91 0.36 2.55e-11 Depression; CRC cis rs9914988 0.887 rs12451790 chr17:27112000 C/G cg07195577 chr17:27052828 TLCD1 0.42 6.02 0.32 4.64e-9 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs11711311 1.000 rs11719303 chr3:113494524 A/T cg15478005 chr3:113465772 ATP6V1A;NAA50 0.43 6.03 0.32 4.37e-9 IgG glycosylation; CRC cis rs13256369 1.000 rs13282915 chr8:8570891 T/G cg06636001 chr8:8085503 FLJ10661 0.44 5.7 0.3 2.63e-8 Obesity-related traits; CRC cis rs853679 0.517 rs35193936 chr6:28076270 A/G cg02631126 chr6:28058918 ZSCAN12L1 0.3 6.11 0.32 2.83e-9 Depression; CRC cis rs7937682 0.883 rs1784776 chr11:111472392 C/T cg09085632 chr11:111637200 PPP2R1B -0.97 -18.57 -0.72 3.59e-53 Primary sclerosing cholangitis; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg16186051 chr20:40247245 CHD6 0.49 7.3 0.37 2.13e-12 Intelligence (multi-trait analysis); CRC cis rs6938 0.618 rs11638130 chr15:75183935 G/A cg14664628 chr15:75095509 CSK -0.6 -9.23 -0.45 3.3e-18 Breast cancer; CRC cis rs344364 0.511 rs2982453 chr16:1949520 G/A cg09830162 chr16:1889614 FAHD1;C16orf73 -0.77 -9.36 -0.46 1.32e-18 Glomerular filtration rate in chronic kidney disease; CRC cis rs11191419 1 rs11191419 chr10:104612335 T/A cg15744005 chr10:104629667 AS3MT -0.39 -7.85 -0.4 6.11e-14 Autism spectrum disorder or schizophrenia;Schizophrenia; CRC cis rs7086803 1.000 rs12217440 chr10:114502218 G/A cg03281572 chr10:114502318 VTI1A 0.75 6.34 0.33 7.77e-10 Lung cancer; CRC cis rs3617 0.539 rs9880619 chr3:52953055 G/A cg07507251 chr3:52567010 NT5DC2 -0.39 -6.12 -0.32 2.61e-9 Red blood cell count;Autism spectrum disorder or schizophrenia; CRC cis rs7737355 0.947 rs10073137 chr5:131091089 A/G cg06307176 chr5:131281290 NA 0.43 6.34 0.33 7.7e-10 Life satisfaction; CRC trans rs7267979 0.866 rs437635 chr20:25456888 A/G cg17903999 chr18:56338584 MALT1 -0.41 -6.95 -0.36 1.98e-11 Liver enzyme levels (alkaline phosphatase); CRC cis rs7762018 0.556 rs75659875 chr6:170054800 A/C cg19338460 chr6:170058176 WDR27 -1.18 -10.81 -0.51 1.7e-23 Thiazide-induced adverse metabolic effects in hypertensive patients; CRC cis rs9322193 0.923 rs9767309 chr6:150037943 A/G cg07701084 chr6:150067640 NUP43 0.56 8.29 0.42 2.92e-15 Lung cancer; CRC cis rs3931020 0.530 rs12125889 chr1:75241971 A/G cg21906852 chr1:75198582 TYW3;CRYZ 0.45 6.02 0.32 4.61e-9 Resistin levels; CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg10800280 chr6:36646508 CDKN1A 0.44 7.2 0.37 4.2e-12 Obesity-related traits; CRC trans rs2303319 0.504 rs55841284 chr2:162560011 A/G cg12500891 chr11:57225987 NA -0.66 -6.09 -0.32 3.19e-9 Cognitive function; CRC cis rs6570726 0.818 rs437978 chr6:145809134 A/G cg13319975 chr6:146136371 FBXO30 -0.38 -5.91 -0.31 8.34e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs270601 0.909 rs2569265 chr5:131704519 T/C cg09877947 chr5:131593287 PDLIM4 -0.44 -7.26 -0.37 2.9e-12 Acylcarnitine levels; CRC cis rs1348850 0.958 rs1548067 chr2:178462914 C/T cg02961200 chr2:178257176 LOC100130691;AGPS 0.52 7.57 0.39 3.85e-13 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs8180040 0.966 rs11914795 chr3:47557722 G/A cg27129171 chr3:47204927 SETD2 0.53 8.18 0.41 6.29e-15 Colorectal cancer; CRC cis rs6461049 0.734 rs1558465 chr7:2151398 G/C cg02951883 chr7:2050386 MAD1L1 -0.6 -9.7 -0.47 1.02e-19 Schizophrenia; CRC cis rs870825 0.556 rs6552811 chr4:185653351 T/A cg04058563 chr4:185651563 MLF1IP -0.7 -8.65 -0.43 2.27e-16 Blood protein levels; CRC cis rs6504622 0.935 rs740617 chr17:45028001 C/T cg16759221 chr17:45003025 GOSR2 -0.53 -8.49 -0.42 7.23e-16 Orofacial clefts; CRC cis rs951366 0.617 rs823075 chr1:205774897 C/T cg26354017 chr1:205819088 PM20D1 0.93 16.02 0.66 4.17e-43 Menarche (age at onset); CRC cis rs17023223 0.508 rs12096448 chr1:119683390 G/A cg05756136 chr1:119680316 WARS2 -0.53 -7.21 -0.37 3.87e-12 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for BMI in active individuals; CRC cis rs9487051 0.676 rs6910119 chr6:109599263 A/G cg21918786 chr6:109611834 NA -0.4 -7.13 -0.37 6.28e-12 Reticulocyte fraction of red cells; CRC cis rs1552244 1.000 rs35741213 chr3:10087661 A/G cg10729496 chr3:10149963 C3orf24 0.55 7.26 0.37 2.73e-12 Alzheimer's disease; CRC cis rs796364 0.715 rs78988795 chr2:201095739 G/A cg25936922 chr2:200820526 C2orf60;C2orf47 -0.66 -5.73 -0.3 2.33e-8 Schizophrenia; CRC cis rs9303401 0.625 rs34963822 chr17:56988424 C/A cg10487724 chr17:56770010 TEX14;RAD51C 0.78 9.8 0.48 4.54e-20 Cognitive test performance; CRC cis rs11997175 0.545 rs7818001 chr8:33807682 G/T cg04338863 chr8:33670619 NA 0.41 6.18 0.32 1.86e-9 Body mass index; CRC cis rs9291683 0.588 rs13121211 chr4:9999539 A/G cg11266682 chr4:10021025 SLC2A9 0.49 10.46 0.5 2.64e-22 Bone mineral density; CRC cis rs4660214 0.724 rs10788933 chr1:39695155 A/G cg11070191 chr1:39582205 MACF1 0.36 5.67 0.3 3.09e-8 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs1046896 0.520 rs8074086 chr17:80818460 A/C cg19500275 chr17:80737654 TBCD 0.5 6.85 0.35 3.67e-11 Glycated hemoglobin levels; CRC cis rs2153535 0.580 rs7761937 chr6:8459434 A/T cg21535247 chr6:8435926 SLC35B3 0.51 7.92 0.4 3.77e-14 Motion sickness; CRC trans rs4650994 1.000 rs4511075 chr1:178518636 G/A cg05059571 chr16:84539110 KIAA1609 -0.48 -7.34 -0.38 1.63e-12 HDL cholesterol levels;HDL cholesterol; CRC cis rs798766 1.000 rs798762 chr4:1731150 T/C cg21505886 chr4:1724428 TMEM129;TACC3 -0.39 -5.6 -0.3 4.46e-8 Bladder cancer;Urinary bladder cancer; CRC cis rs1997103 0.765 rs55686950 chr7:55396552 A/C cg17469321 chr7:55412551 NA 0.74 11.38 0.53 1.54e-25 QRS interval (sulfonylurea treatment interaction); CRC trans rs1005277 0.579 rs2008449 chr10:38414204 A/T cg27523141 chr10:43048294 ZNF37B -0.49 -7.35 -0.38 1.61e-12 Extrinsic epigenetic age acceleration; CRC cis rs7208859 0.673 rs9911989 chr17:29237702 A/C cg14008862 chr17:28927542 LRRC37B2 -0.57 -5.97 -0.31 6.08e-9 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs1883415 0.530 rs3765311 chr6:24503862 G/T cg20631270 chr6:24437470 GPLD1 -0.38 -5.83 -0.31 1.32e-8 Liver enzyme levels (alkaline phosphatase); CRC cis rs11971779 0.680 rs10229358 chr7:139052545 C/T cg23387468 chr7:139079360 LUC7L2 -0.42 -7.31 -0.37 2.02e-12 Diisocyanate-induced asthma; CRC cis rs798554 0.660 rs2527692 chr7:2856533 G/A cg04166393 chr7:2884313 GNA12 0.38 5.79 0.3 1.64e-8 Height; CRC cis rs2549003 1.000 rs6873426 chr5:131818631 G/T cg21138405 chr5:131827807 IRF1 0.57 11.33 0.53 2.39e-25 Asthma (sex interaction); CRC cis rs17711722 0.727 rs2658585 chr7:65461941 A/T cg02869306 chr7:64672164 INTS4L1 -0.35 -5.8 -0.3 1.52e-8 Calcium levels; CRC cis rs10504229 0.683 rs6999351 chr8:58127227 C/T cg22535103 chr8:58192502 C8orf71 -0.7 -9.34 -0.46 1.47e-18 Developmental language disorder (linguistic errors); CRC cis rs4716602 0.596 rs34977094 chr7:156160864 C/T cg16983916 chr7:156159713 NA -0.39 -6.9 -0.36 2.65e-11 Anti-saccade response; CRC cis rs10089 1.000 rs10089 chr5:127522543 C/T cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.73 9.42 0.46 8.12e-19 Ileal carcinoids; CRC cis rs8180040 0.966 rs13079098 chr3:47442863 A/G cg27129171 chr3:47204927 SETD2 0.6 9.6 0.47 2.08e-19 Colorectal cancer; CRC cis rs6502050 0.871 rs8072702 chr17:80074280 C/T cg25804541 chr17:80189381 SLC16A3 0.32 6.24 0.33 1.33e-9 Life satisfaction; CRC cis rs28386778 0.830 rs7209321 chr17:61855668 A/C cg25654072 chr17:61904446 PSMC5;FTSJ3 0.72 10.89 0.51 8.67e-24 Prudent dietary pattern; CRC cis rs3741151 1.000 rs7125978 chr11:73039229 G/A cg17517138 chr11:73019481 ARHGEF17 0.63 6.59 0.34 1.71e-10 GIP levels in response to oral glucose tolerance test (120 minutes); CRC cis rs73206853 0.841 rs73206894 chr12:110876328 C/T cg12870014 chr12:110450643 ANKRD13A 0.75 8.18 0.41 6.45e-15 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC cis rs6570726 0.905 rs452770 chr6:145847162 T/C cg05347473 chr6:146136440 FBXO30 0.38 6.09 0.32 3.19e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs6570726 0.791 rs6570694 chr6:145911204 C/G cg13319975 chr6:146136371 FBXO30 -0.44 -6.44 -0.33 4.17e-10 Lobe attachment (rater-scored or self-reported); CRC cis rs10256972 0.552 rs2960831 chr7:1201192 A/T cg07308232 chr7:1071921 C7orf50 -0.42 -5.72 -0.3 2.36e-8 Longevity;Endometriosis; CRC cis rs28386778 0.897 rs2727323 chr17:61921999 G/T cg11494091 chr17:61959527 GH2 0.6 10.33 0.49 7.77e-22 Prudent dietary pattern; CRC trans rs916888 0.821 rs199506 chr17:44859031 A/G cg07870213 chr5:140052090 DND1 -0.86 -10.19 -0.49 2.29e-21 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC trans rs10982213 0.830 rs2274163 chr9:117188714 C/T cg20617676 chr7:123389167 WASL 0.38 6.28 0.33 1.08e-9 Interleukin-6 levels; CRC cis rs2739330 0.760 rs5751760 chr22:24243573 G/A cg04234412 chr22:24373322 LOC391322 -0.78 -12.84 -0.58 7.49e-31 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs6163 0.727 rs284854 chr10:104574562 T/G cg23093090 chr10:104574429 C10orf26 0.35 5.67 0.3 3.15e-8 Waist circumference;Hip circumference; CRC cis rs1215050 0.740 rs783938 chr4:99010336 A/T cg05340658 chr4:99064831 C4orf37 -0.48 -7.28 -0.37 2.43e-12 Waist-to-hip ratio adjusted for body mass index; CRC trans rs904251 0.828 rs1757178 chr6:37486310 C/T cg22586996 chr5:158523907 EBF1 -0.34 -5.97 -0.31 6.02e-9 Cognitive performance; CRC cis rs7772486 0.686 rs9390357 chr6:146129347 A/G cg13319975 chr6:146136371 FBXO30 -0.43 -6.34 -0.33 7.59e-10 Lobe attachment (rater-scored or self-reported); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg05977147 chr6:88182533 SLC35A1 0.41 6.41 0.33 5e-10 Liver disease severity in Alagille syndrome; CRC cis rs642858 1.000 rs9403133 chr6:140301947 A/G cg27524944 chr6:140295369 NA -0.36 -5.97 -0.31 6.17e-9 Type 2 diabetes; CRC cis rs3540 0.553 rs12592611 chr15:91004093 C/T cg22089800 chr15:90895588 ZNF774 0.58 9.65 0.47 1.5e-19 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; CRC cis rs2204008 0.684 rs11514164 chr12:38036494 C/T cg13010199 chr12:38710504 ALG10B 0.46 6.1 0.32 3.03e-9 Bladder cancer; CRC cis rs6860806 0.507 rs274570 chr5:131713226 C/T cg24060327 chr5:131705240 SLC22A5 0.53 7.98 0.4 2.47e-14 Breast cancer; CRC cis rs6500395 1.000 rs9938633 chr16:48682093 G/C cg04672837 chr16:48644449 N4BP1 0.45 6.63 0.34 1.38e-10 Response to tocilizumab in rheumatoid arthritis; CRC cis rs17209837 1.000 rs17149647 chr7:87086931 T/C cg00919237 chr7:87102261 ABCB4 -0.47 -5.8 -0.3 1.54e-8 Gallbladder cancer; CRC cis rs17767392 0.914 rs7147668 chr14:71857427 G/A cg13720639 chr14:72061746 SIPA1L1 -0.55 -6.95 -0.36 1.96e-11 Mitral valve prolapse; CRC cis rs514406 0.621 rs928452 chr1:53195926 G/C cg08859206 chr1:53392774 SCP2 0.42 6.51 0.34 2.76e-10 Monocyte count; CRC cis rs9910055 0.529 rs2523161 chr17:42179405 C/T cg19774624 chr17:42201019 HDAC5 0.54 7.37 0.38 1.37e-12 Total body bone mineral density; CRC cis rs7666738 0.830 rs4699577 chr4:98846513 G/A cg05340658 chr4:99064831 C4orf37 0.58 8.59 0.43 3.46e-16 Colonoscopy-negative controls vs population controls; CRC cis rs6570726 0.935 rs390252 chr6:145856896 A/G cg23711669 chr6:146136114 FBXO30 0.7 12.46 0.57 1.81e-29 Lobe attachment (rater-scored or self-reported); CRC cis rs7762018 0.607 rs75438963 chr6:170047695 G/A cg19338460 chr6:170058176 WDR27 -1.25 -10.26 -0.49 1.27e-21 Thiazide-induced adverse metabolic effects in hypertensive patients; CRC cis rs6496667 0.821 rs4412956 chr15:90885717 G/T cg04176472 chr15:90893244 GABARAPL3 -0.59 -6.93 -0.36 2.2e-11 Rheumatoid arthritis; CRC trans rs1005277 0.602 rs1780141 chr10:38504299 T/C cg27523141 chr10:43048294 ZNF37B 0.47 6.89 0.36 2.87e-11 Extrinsic epigenetic age acceleration; CRC cis rs1799949 0.965 rs12950779 chr17:41306523 C/T cg01879757 chr17:41196368 BRCA1 -0.44 -6.72 -0.35 8.23e-11 Menopause (age at onset); CRC cis rs72802342 0.510 rs12932952 chr16:75365486 C/T cg03315344 chr16:75512273 CHST6 0.48 5.8 0.3 1.59e-8 Advanced age-related macular degeneration; CRC cis rs6693567 0.545 rs11205382 chr1:150442466 G/A cg15654264 chr1:150340011 RPRD2 -0.4 -5.83 -0.31 1.29e-8 Migraine; CRC cis rs1178968 0.901 rs7783232 chr7:72765171 C/G cg25889504 chr7:72793014 NA 0.54 6.17 0.32 2.06e-9 Triglyceride levels; CRC cis rs2011503 1.000 rs2965178 chr19:19482911 T/G cg11584989 chr19:19387371 SF4 -0.45 -5.63 -0.3 3.8e-8 Bipolar disorder; CRC cis rs7246657 0.882 rs28623164 chr19:37913453 G/A cg23950597 chr19:37808831 NA -0.49 -6.09 -0.32 3.18e-9 Coronary artery calcification; CRC cis rs4731207 0.698 rs7799938 chr7:124521391 C/T cg23710748 chr7:124431027 NA -0.38 -6.08 -0.32 3.42e-9 Cutaneous malignant melanoma; CRC cis rs11098499 0.754 rs11724409 chr4:120252361 A/G cg24375607 chr4:120327624 NA 0.47 7.6 0.39 3.06e-13 Corneal astigmatism; CRC cis rs9322193 0.923 rs9689723 chr6:149977071 C/A cg13206674 chr6:150067644 NUP43 0.65 9.8 0.48 4.58e-20 Lung cancer; CRC cis rs919433 0.929 rs10931779 chr2:198166825 A/G cg03934865 chr2:198174659 NA -0.48 -8.92 -0.44 3.26e-17 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC cis rs6424115 1.000 rs34477640 chr1:24154067 T/C cg10978503 chr1:24200527 CNR2 -0.5 -8.8 -0.44 8.16e-17 Immature fraction of reticulocytes; CRC cis rs2415984 0.600 rs61993295 chr14:46932614 T/C cg14871534 chr14:47121158 RPL10L -0.42 -5.97 -0.31 6.01e-9 Number of children ever born; CRC trans rs7615952 0.512 rs2979336 chr3:125357470 G/A cg00769240 chr8:12517080 NA -0.73 -10.15 -0.49 3.08e-21 Blood pressure (smoking interaction); CRC cis rs9368481 0.672 rs3931463 chr6:26939797 G/A cg05192639 chr6:26864778 GUSBL1 0.35 6.44 0.33 4.29e-10 Autism spectrum disorder or schizophrenia; CRC cis rs17345786 1.000 rs3804778 chr3:101294572 C/T cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.58 6.6 0.34 1.63e-10 Colonoscopy-negative controls vs population controls; CRC cis rs3126085 1.000 rs3126092 chr1:152307955 T/A cg09127314 chr1:152161683 NA -0.45 -5.61 -0.3 4.29e-8 Atopic dermatitis; CRC cis rs9915657 0.773 rs9912974 chr17:70095963 C/T cg09344028 chr17:70110421 NA 0.51 8.27 0.41 3.46e-15 Thyroid hormone levels; CRC cis rs9486719 0.843 rs3860231 chr6:97036563 G/A cg06623918 chr6:96969491 KIAA0776 -0.82 -11.38 -0.53 1.57e-25 Migraine;Coronary artery disease; CRC cis rs896854 0.624 rs9297949 chr8:95969445 A/C cg13393036 chr8:95962371 TP53INP1 -0.53 -9.16 -0.45 5.7e-18 Type 2 diabetes; CRC cis rs35146811 0.961 rs1880949 chr7:99722266 A/C cg13334819 chr7:99746414 C7orf59 0.63 8.31 0.42 2.62e-15 Coronary artery disease; CRC cis rs7209700 0.638 rs4629025 chr17:45337435 A/T cg08085267 chr17:45401833 C17orf57 0.48 6.98 0.36 1.59e-11 IgG glycosylation; CRC cis rs6582630 0.638 rs12424222 chr12:38548273 C/T cg26384229 chr12:38710491 ALG10B -0.52 -7.61 -0.39 2.96e-13 Drug-induced liver injury (flucloxacillin); CRC cis rs6951245 0.554 rs35126802 chr7:1134842 C/T cg24642844 chr7:1081250 C7orf50 -0.48 -6.23 -0.32 1.44e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs7772486 0.754 rs864148 chr6:145976675 T/C cg13319975 chr6:146136371 FBXO30 0.45 6.49 0.34 3.23e-10 Lobe attachment (rater-scored or self-reported); CRC trans rs6076960 0.684 rs6054059 chr20:6262472 G/T cg21095983 chr6:86352623 SYNCRIP 0.59 8.48 0.42 7.65e-16 Smooth-surface caries; CRC cis rs2243480 1.000 rs316327 chr7:65609201 G/T cg18252515 chr7:66147081 NA 1.19 14.3 0.62 2.14e-36 Diabetic kidney disease; CRC cis rs4481233 0.528 rs115776655 chr4:10381329 C/T cg11266682 chr4:10021025 SLC2A9 -0.46 -6.72 -0.35 8.09e-11 Metabolic traits; CRC cis rs7044106 0.762 rs10984972 chr9:123409864 T/C cg09586646 chr9:123605570 PSMD5;LOC253039 0.6 8.9 0.44 3.69e-17 Hip circumference adjusted for BMI; CRC cis rs929354 0.772 rs3802125 chr7:156970563 A/C cg05182265 chr7:156933206 UBE3C -0.73 -13.35 -0.59 8.95e-33 Body mass index; CRC cis rs7618915 0.571 rs6778844 chr3:52596398 C/T cg15147215 chr3:52552868 STAB1 0.64 10.59 0.5 9.25e-23 Bipolar disorder; CRC cis rs939658 0.967 rs7171067 chr15:79452727 G/T cg17916960 chr15:79447300 NA 0.46 7.56 0.38 3.99e-13 Refractive error; CRC cis rs6785206 0.527 rs9844706 chr3:128380781 G/A cg16766828 chr3:128327626 NA -0.47 -5.73 -0.3 2.21e-8 Lymphocyte percentage of white cells; CRC cis rs9682041 0.561 rs7616830 chr3:170146445 A/G cg11886554 chr3:170076028 SKIL 0.68 7.65 0.39 2.28e-13 Glomerular filtration rate in non diabetics (creatinine);Glomerular filtration rate (creatinine); CRC cis rs13256369 1.000 rs7004438 chr8:8574379 C/T cg17143192 chr8:8559678 CLDN23 0.47 6.27 0.33 1.11e-9 Obesity-related traits; CRC cis rs1559088 0.948 rs7247748 chr19:33594023 T/C cg27124370 chr19:33622961 WDR88 0.45 6.26 0.33 1.21e-9 Bone ultrasound measurement (broadband ultrasound attenuation); CRC cis rs910316 1.000 rs10149880 chr14:75633008 A/G cg08847533 chr14:75593920 NEK9 -0.97 -18.51 -0.71 6.19e-53 Height; CRC cis rs9311474 0.607 rs11711421 chr3:52561779 C/T cg07507251 chr3:52567010 NT5DC2 0.47 7.27 0.37 2.58e-12 Electroencephalogram traits; CRC cis rs270601 0.770 rs61352298 chr5:131600589 G/C cg12564285 chr5:131593104 PDLIM4 0.54 10.41 0.5 3.98e-22 Acylcarnitine levels; CRC cis rs11148252 0.875 rs9526913 chr13:52975837 T/C cg02158880 chr13:53174818 NA 0.43 6.44 0.33 4.24e-10 Lewy body disease; CRC cis rs1552244 0.882 rs28366039 chr3:10028988 C/A cg00166722 chr3:10149974 C3orf24 0.6 7.33 0.37 1.82e-12 Alzheimer's disease; CRC cis rs10504229 0.953 rs72650891 chr8:58179697 T/G cg05313129 chr8:58192883 C8orf71 -0.47 -6.99 -0.36 1.49e-11 Developmental language disorder (linguistic errors); CRC cis rs519973 0.775 rs12638043 chr3:187635232 C/T cg10168494 chr3:187635183 NA 0.5 8.65 0.43 2.26e-16 Allergic disease (asthma, hay fever or eczema); CRC cis rs7589728 1.000 rs12473740 chr2:88527647 A/G cg07952391 chr2:88470173 THNSL2 0.65 6.63 0.34 1.4e-10 Plasma clusterin levels; CRC cis rs921968 0.643 rs864990 chr2:219494037 G/A cg02176678 chr2:219576539 TTLL4 0.49 7.86 0.4 5.56e-14 Mean corpuscular hemoglobin concentration; CRC cis rs9527 0.545 rs12784384 chr10:104957594 G/C cg04362960 chr10:104952993 NT5C2 0.61 8.51 0.42 6.45e-16 Arsenic metabolism; CRC cis rs1059312 0.500 rs12303338 chr12:129276641 C/T cg09035930 chr12:129282057 SLC15A4 -0.44 -6.59 -0.34 1.77e-10 Systemic lupus erythematosus; CRC cis rs3733585 0.699 rs6449176 chr4:9967843 G/A cg00071950 chr4:10020882 SLC2A9 -0.55 -9.72 -0.47 8.53e-20 Cleft plate (environmental tobacco smoke interaction); CRC cis rs2976388 0.609 rs2585145 chr8:143799457 G/A cg24046110 chr8:143859143 LYNX1 0.48 8.24 0.41 4.26e-15 Urinary tract infection frequency; CRC cis rs11997175 0.574 rs4236733 chr8:33655582 G/A cg04338863 chr8:33670619 NA 0.39 6.84 0.35 3.92e-11 Body mass index; CRC cis rs4727027 0.727 rs3801980 chr7:148878620 T/A cg23583168 chr7:148888333 NA -0.77 -11.51 -0.54 5.29e-26 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC cis rs66569888 0.607 rs11687271 chr2:106727456 G/A cg16099169 chr2:106886729 NA -0.37 -5.67 -0.3 3.16e-8 Facial morphology (factor 23); CRC cis rs79839061 0.562 rs10516158 chr4:942439 A/G cg07828340 chr4:882639 GAK -1.12 -10.69 -0.51 4.43e-23 Intelligence (multi-trait analysis); CRC cis rs10751667 0.621 rs7396049 chr11:1001561 G/A cg23136738 chr11:925521 AP2A2 -0.41 -6.62 -0.34 1.49e-10 Alzheimer's disease (late onset); CRC trans rs10982213 0.830 rs2274163 chr9:117188714 C/T cg09484009 chr8:97274693 MTERFD1;PTDSS1 -0.41 -5.96 -0.31 6.52e-9 Interleukin-6 levels; CRC trans rs11039798 0.588 rs643668 chr11:48413399 C/G cg15704280 chr7:45808275 SEPT13 -0.68 -7.42 -0.38 9.81e-13 Axial length; CRC cis rs7727544 0.735 rs274559 chr5:131720070 A/G cg21138405 chr5:131827807 IRF1 0.32 5.76 0.3 1.91e-8 Blood metabolite levels; CRC cis rs11229555 1.000 rs7102510 chr11:58371283 T/G cg15696309 chr11:58395628 NA -0.95 -13.36 -0.59 7.99e-33 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; CRC cis rs3771570 0.792 rs4675970 chr2:242200406 G/A cg21155796 chr2:242212141 HDLBP 0.58 6.82 0.35 4.34e-11 Prostate cancer; CRC cis rs34779708 0.931 rs4934535 chr10:35432721 G/T cg03585969 chr10:35415529 CREM 0.66 8.68 0.43 1.88e-16 Inflammatory bowel disease;Crohn's disease; CRC cis rs1656402 1.000 rs1656400 chr2:233427783 A/G cg03852847 chr2:233439513 NA -0.34 -6.33 -0.33 8.16e-10 Non-small cell lung cancer (survival); CRC cis rs514406 0.929 rs564273 chr1:53332445 G/C cg25767906 chr1:53392781 SCP2 -0.47 -7.78 -0.39 9.5e-14 Monocyte count; CRC cis rs79349575 0.783 rs55771415 chr17:46999937 C/T cg22482690 chr17:47019901 SNF8 0.48 8.07 0.41 1.33e-14 Type 2 diabetes; CRC cis rs7772486 0.654 rs702321 chr6:146006695 A/G cg13319975 chr6:146136371 FBXO30 0.41 6.18 0.32 1.9e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs10256972 0.552 rs2960837 chr7:1203957 A/G cg16145915 chr7:1198662 ZFAND2A -0.51 -10.71 -0.51 3.59e-23 Longevity;Endometriosis; CRC cis rs10504229 0.906 rs112793785 chr8:58190537 T/C cg02290350 chr8:58132656 NA -0.42 -5.98 -0.31 5.73e-9 Developmental language disorder (linguistic errors); CRC cis rs12541335 0.639 rs11779277 chr8:22200683 C/T cg02463440 chr8:22132932 PIWIL2 0.5 8.67 0.43 2.02e-16 Hypertriglyceridemia; CRC cis rs4700695 0.841 rs417074 chr5:65314894 C/T cg21114390 chr5:65439923 SFRS12 0.64 6.6 0.34 1.61e-10 Facial morphology (factor 19); CRC cis rs11166629 1.000 rs6577713 chr8:135645592 C/A cg27224718 chr8:135614730 ZFAT 0.52 7.62 0.39 2.7e-13 Smoking quantity; CRC cis rs1691799 0.867 rs1168342 chr12:66758734 A/T cg16791601 chr12:66731901 HELB -0.73 -12.82 -0.58 8.7e-31 White blood cell count (basophil); CRC cis rs801193 1.000 rs7783924 chr7:66209057 A/C cg00343986 chr7:65444356 GUSB 0.49 7.26 0.37 2.87e-12 Aortic root size; CRC cis rs2842992 1.000 rs2758322 chr6:160075188 G/T cg19482086 chr6:160211437 TCP1;MRPL18 0.71 9.79 0.47 5.14e-20 Age-related macular degeneration (geographic atrophy); CRC cis rs524281 0.814 rs10896093 chr11:65958411 C/G cg14036092 chr11:66035641 RAB1B -0.47 -5.69 -0.3 2.88e-8 Electroencephalogram traits; CRC cis rs7833790 0.963 rs28823280 chr8:82777716 G/A cg27398817 chr8:82754497 SNX16 0.51 6.21 0.32 1.61e-9 Diastolic blood pressure; CRC cis rs11764590 0.694 rs55860148 chr7:2105594 G/A cg21155852 chr7:2048760 MAD1L1 -0.44 -6.26 -0.33 1.2e-9 Neuroticism; CRC cis rs57221529 0.766 rs12518859 chr5:587432 C/T cg17948913 chr5:572064 NA 0.56 6.29 0.33 1e-9 Lung disease severity in cystic fibrosis; CRC cis rs1552244 0.810 rs7612908 chr3:10089148 A/G cg16606324 chr3:10149918 C3orf24 0.72 9.82 0.48 3.92e-20 Alzheimer's disease; CRC cis rs1003719 0.553 rs1063948 chr21:38574674 C/G cg10648535 chr21:38446584 PIGP;TTC3 -0.45 -6.23 -0.32 1.41e-9 Eye color traits; CRC cis rs8072100 0.905 rs9895274 chr17:45539117 C/T cg25173405 chr17:45401733 C17orf57 -0.51 -8.09 -0.41 1.18e-14 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs1552244 1.000 rs17032277 chr3:10077023 T/C cg10729496 chr3:10149963 C3orf24 0.55 7.11 0.37 7.07e-12 Alzheimer's disease; CRC cis rs3106136 0.934 rs35995707 chr4:95167150 C/G cg11021082 chr4:95130006 SMARCAD1 -0.47 -7.21 -0.37 3.78e-12 Capecitabine sensitivity; CRC cis rs12586317 0.525 rs10144430 chr14:35433682 T/A cg16230307 chr14:35515116 FAM177A1 0.68 8.63 0.43 2.76e-16 Psoriasis; CRC cis rs873946 0.590 rs7071777 chr10:134559976 T/A cg18305652 chr10:134549665 INPP5A 0.47 6.03 0.32 4.46e-9 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CRC cis rs2252521 0.524 rs2529480 chr7:29043120 G/A cg11728747 chr7:29037910 CPVL -0.49 -7.03 -0.36 1.2e-11 Cognitive performance; CRC cis rs5753618 0.509 rs5749224 chr22:31558549 C/T cg22777020 chr22:31556080 RNF185 -0.53 -6.07 -0.32 3.45e-9 Colorectal cancer; CRC cis rs9837602 0.938 rs9823908 chr3:99795507 A/G cg07805332 chr3:99536008 MIR548G;C3orf26 -0.47 -6.17 -0.32 1.98e-9 Breast cancer; CRC cis rs769267 0.896 rs10405625 chr19:19579046 T/G cg01262667 chr19:19385393 TM6SF2 0.36 5.84 0.31 1.25e-8 Tonsillectomy; CRC cis rs597539 0.652 rs660614 chr11:68659488 G/A cg04772025 chr11:68637568 NA 0.48 7.36 0.38 1.51e-12 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC trans rs6561151 1.000 rs6561151 chr13:44484706 G/A cg12856521 chr11:46389249 DGKZ 0.63 9.38 0.46 1.1e-18 Crohn's disease; CRC cis rs7727544 0.904 rs7736102 chr5:131604257 G/A cg22638593 chr5:131593259 PDLIM4 0.36 6.9 0.36 2.73e-11 Blood metabolite levels; CRC cis rs453301 0.686 rs6748 chr8:8890802 C/T cg14979609 chr8:8086686 FLJ10661 0.38 6.25 0.33 1.26e-9 Joint mobility (Beighton score); CRC cis rs10504229 0.906 rs61638902 chr8:58193511 A/C cg24829409 chr8:58192753 C8orf71 -0.58 -10.01 -0.48 9.42e-21 Developmental language disorder (linguistic errors); CRC cis rs4689592 0.554 rs66925245 chr4:7071999 C/T cg26116260 chr4:7069785 GRPEL1 -0.9 -11.33 -0.53 2.46e-25 Monocyte percentage of white cells; CRC cis rs9583531 0.600 rs2119479 chr13:111371181 A/C cg24331049 chr13:111365604 ING1 0.57 7.61 0.39 2.85e-13 Coronary artery disease; CRC cis rs7633770 0.805 rs11130098 chr3:46661926 A/G cg11219411 chr3:46661640 NA -0.74 -13.42 -0.59 4.69e-33 Coronary artery disease; CRC trans rs7726839 0.574 rs11134148 chr5:637107 C/T cg25482853 chr8:67687455 SGK3 1.11 12.99 0.58 2.06e-31 Obesity-related traits; CRC trans rs10411161 1.000 rs2867318 chr19:52363472 T/C cg22319618 chr22:45562946 NUP50 -0.52 -6.03 -0.32 4.4e-9 Breast cancer; CRC cis rs853679 0.517 rs9348797 chr6:28137533 G/C cg25164649 chr6:28176230 NA 0.78 9.66 0.47 1.33e-19 Depression; CRC cis rs4363385 0.747 rs1415960 chr1:152973571 G/T cg25856811 chr1:152973957 SPRR3 -0.25 -6.77 -0.35 5.85e-11 Inflammatory skin disease; CRC cis rs896854 0.818 rs13262110 chr8:95926890 C/T cg16049864 chr8:95962084 TP53INP1 -0.62 -10.84 -0.51 1.34e-23 Type 2 diabetes; CRC cis rs6540559 0.673 rs17015330 chr1:210012795 T/G cg22029157 chr1:209979665 IRF6 0.63 7.36 0.38 1.48e-12 Cleft lip with or without cleft palate; CRC cis rs4253772 0.530 rs9627387 chr22:46684678 A/G cg03482458 chr22:46692211 CN5H6.4;GTSE1 0.58 8.19 0.41 5.88e-15 LDL cholesterol;Cholesterol, total; CRC trans rs208520 0.690 rs1580430 chr6:66715162 T/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 1.0 14.05 0.61 1.94e-35 Exhaled nitric oxide output; CRC cis rs868943 0.714 rs13216178 chr6:116392629 T/G cg26893134 chr6:116381904 FRK 0.27 6.45 0.33 4.07e-10 Total cholesterol levels; CRC cis rs3741151 0.773 rs17244616 chr11:73293112 C/T cg17517138 chr11:73019481 ARHGEF17 0.99 7.81 0.4 7.63e-14 GIP levels in response to oral glucose tolerance test (120 minutes); CRC cis rs2762353 0.595 rs12207270 chr6:25751721 A/G cg03264133 chr6:25882463 NA -0.71 -10.05 -0.48 6.59e-21 Blood metabolite levels; CRC cis rs9611565 0.512 rs5751145 chr22:42133552 C/T cg06481639 chr22:41940642 POLR3H 0.51 5.62 0.3 4.01e-8 Vitiligo; CRC cis rs875971 0.830 rs809025 chr7:65849819 C/G cg18252515 chr7:66147081 NA -0.41 -5.94 -0.31 7.15e-9 Aortic root size; CRC cis rs67478160 0.634 rs7141928 chr14:104219949 C/T cg01849466 chr14:104193079 ZFYVE21 -0.55 -10.35 -0.5 6.21e-22 Schizophrenia; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg01952724 chr19:51611733 CTU1 0.46 6.41 0.33 4.94e-10 Response to antipsychotic treatment; CRC cis rs12580194 0.593 rs66516917 chr12:55749131 T/G cg19537932 chr12:55886519 OR6C68 -0.68 -8.88 -0.44 4.57e-17 Cancer; CRC cis rs11628318 0.713 rs1998419 chr14:103050397 C/G cg08075719 chr14:103021372 NA -0.69 -9.22 -0.45 3.67e-18 Platelet count; CRC cis rs853679 0.546 rs200949 chr6:27835435 A/G cg26587870 chr6:27730563 NA -0.57 -6.27 -0.33 1.12e-9 Depression; CRC cis rs4237845 0.715 rs4760340 chr12:58275176 A/T cg02175503 chr12:58329896 NA 0.52 7.48 0.38 6.61e-13 Intelligence (multi-trait analysis); CRC cis rs7647973 1.000 rs11710434 chr3:49346130 T/C cg20833759 chr3:49053208 WDR6;DALRD3 0.53 8.0 0.4 2.12e-14 Menarche (age at onset); CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg10780647 chr20:3800838 C20orf29 0.42 5.98 0.31 5.9e-9 Anxiety disorder; CRC cis rs1881797 1.000 rs10925069 chr1:247681313 C/T cg21399703 chr1:247681439 NA -0.55 -9.98 -0.48 1.14e-20 Acute lymphoblastic leukemia (childhood); CRC cis rs539096 0.500 rs2527776 chr1:44345292 G/A cg13606994 chr1:44402422 ARTN -0.34 -5.79 -0.3 1.65e-8 Intelligence (multi-trait analysis); CRC cis rs2576037 0.526 rs4258717 chr18:44456954 T/C cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.66 -10.77 -0.51 2.21e-23 Personality dimensions; CRC cis rs9811920 0.666 rs793456 chr3:99525631 G/A cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G -0.43 -6.09 -0.32 3.16e-9 Axial length; CRC cis rs644799 1.000 rs3748256 chr11:95521953 A/G cg03916912 chr11:95522834 CEP57;FAM76B 0.95 18.1 0.71 2.67e-51 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs6502050 0.723 rs8077209 chr17:80163221 A/G cg09264619 chr17:80180166 NA -0.37 -6.32 -0.33 8.43e-10 Life satisfaction; CRC cis rs4728302 0.869 rs12707130 chr7:133616739 G/T cg10665199 chr7:133106180 EXOC4 0.4 6.05 0.32 3.92e-9 Intelligence;Intelligence (multi-trait analysis); CRC cis rs6088580 0.634 rs6142157 chr20:32984172 C/G cg08999081 chr20:33150536 PIGU -0.62 -11.62 -0.54 2.13e-26 Glomerular filtration rate (creatinine); CRC cis rs10946940 0.965 rs6915266 chr6:27528643 G/A cg25164649 chr6:28176230 NA -0.41 -5.79 -0.3 1.63e-8 Systemic lupus erythematosus; CRC cis rs17384381 0.953 rs2076699 chr1:85817295 G/A cg16011679 chr1:85725395 C1orf52 0.67 6.91 0.36 2.58e-11 Lobe attachment (rater-scored or self-reported); CRC cis rs4665809 0.590 rs11552518 chr2:26455127 G/A cg25036284 chr2:26402008 FAM59B 0.62 7.86 0.4 5.64e-14 Gut microbiome composition (summer); CRC cis rs826838 0.967 rs11183514 chr12:38760744 A/T cg26384229 chr12:38710491 ALG10B 0.75 10.56 0.5 1.25e-22 Heart rate; CRC cis rs2249694 0.922 rs8192780 chr10:135354125 T/G cg20169779 chr10:135381914 SYCE1 0.54 8.62 0.43 2.79e-16 Obesity-related traits; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg07835289 chr1:236030215 LYST 0.38 6.05 0.32 3.98e-9 Liver disease severity in Alagille syndrome; CRC trans rs1005277 0.505 rs10827835 chr10:38150709 G/A cg23533926 chr12:111358616 MYL2 0.44 6.54 0.34 2.36e-10 Extrinsic epigenetic age acceleration; CRC cis rs9303401 0.614 rs35308719 chr17:57163501 C/T cg02118635 chr17:56770003 RAD51C;TEX14 0.68 8.42 0.42 1.15e-15 Cognitive test performance; CRC cis rs1059312 0.966 rs12368452 chr12:129277164 C/A cg09035930 chr12:129282057 SLC15A4 0.55 9.2 0.45 4.2e-18 Systemic lupus erythematosus; CRC cis rs9303280 0.806 rs11078928 chr17:38064469 T/C cg11212589 chr17:38028394 ZPBP2 0.41 7.42 0.38 1.03e-12 Self-reported allergy; CRC cis rs7412746 0.658 rs3768015 chr1:150812954 C/T cg17724175 chr1:150552817 MCL1 0.5 7.49 0.38 6.23e-13 Melanoma; CRC cis rs78456975 0.941 rs28913033 chr2:1523194 T/C cg01028140 chr2:1542097 TPO -0.58 -5.71 -0.3 2.54e-8 Placebo response in major depressive disorder (% change in symptom score); CRC cis rs1707322 0.752 rs11211152 chr1:46114157 C/T cg06784218 chr1:46089804 CCDC17 0.64 12.01 0.55 8.66e-28 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs418053 0.648 rs204228 chr6:13680776 A/G cg02206980 chr6:13574034 SIRT5 -0.38 -6.19 -0.32 1.77e-9 Breast cancer; CRC cis rs910316 1.000 rs4903279 chr14:75546583 C/T cg08847533 chr14:75593920 NEK9 0.93 17.75 0.7 6.21e-50 Height; CRC cis rs1568889 0.941 rs35357280 chr11:28322745 A/G cg06544937 chr11:28130018 METT5D1;KIF18A 0.7 7.98 0.4 2.39e-14 Bipolar disorder; CRC cis rs9463078 0.691 rs10948229 chr6:45306371 A/G cg25276700 chr6:44698697 NA 0.25 6.11 0.32 2.89e-9 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; CRC cis rs2806561 0.704 rs856510 chr1:23524407 A/C cg12483005 chr1:23474871 LUZP1 0.49 7.01 0.36 1.33e-11 Height; CRC cis rs7951870 0.645 rs10769205 chr11:46723603 A/G cg19486271 chr11:47235900 DDB2 0.47 7.2 0.37 4.07e-12 Schizophrenia; CRC cis rs7917772 0.502 rs2296584 chr10:104244323 T/A cg11453585 chr10:104263688 ACTR1A;SUFU 0.92 17.05 0.68 3.65e-47 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC cis rs7618915 0.501 rs3852066 chr3:52621839 C/T cg05573699 chr3:52720067 GNL3;PBRM1 -0.47 -6.96 -0.36 1.87e-11 Bipolar disorder; CRC cis rs9487051 0.872 rs9386790 chr6:109608460 G/T cg21918786 chr6:109611834 NA 0.43 7.78 0.39 9.33e-14 Reticulocyte fraction of red cells; CRC cis rs9649213 0.593 rs12704989 chr7:98029438 G/T cg00277769 chr7:97922759 BAIAP2L1 -0.57 -9.69 -0.47 1.05e-19 Prostate cancer (SNP x SNP interaction); CRC cis rs2425143 0.598 rs2425118 chr20:34324098 G/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.49 -6.55 -0.34 2.15e-10 Blood protein levels; CRC cis rs6681460 0.649 rs967325 chr1:67003722 C/T cg02459107 chr1:67143332 SGIP1 0.39 6.06 0.32 3.78e-9 Presence of antiphospholipid antibodies; CRC cis rs6696846 0.905 rs11240349 chr1:205041015 G/A cg03948781 chr1:205179583 DSTYK 0.41 5.84 0.31 1.25e-8 Red blood cell count; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg23141096 chr10:98347050 TM9SF3 0.42 6.22 0.32 1.52e-9 Intelligence (multi-trait analysis); CRC cis rs6429082 0.755 rs291367 chr1:235690800 G/A cg26050004 chr1:235667680 B3GALNT2 0.61 8.92 0.44 3.39e-17 Adiposity; CRC cis rs1577917 0.958 rs4707229 chr6:86546237 C/A cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.51 -6.67 -0.35 1.07e-10 Response to antipsychotic treatment; CRC cis rs12291225 0.645 rs3763950 chr11:14278049 T/A cg05501817 chr11:14380813 RRAS2 -0.46 -6.04 -0.32 4.12e-9 Sense of smell; CRC cis rs7584330 0.657 rs10190310 chr2:238352282 C/T cg11271282 chr2:238384023 NA 0.45 5.7 0.3 2.72e-8 Prostate cancer; CRC cis rs7512552 0.839 rs7523428 chr1:150430472 G/A cg15654264 chr1:150340011 RPRD2 0.58 8.22 0.41 4.63e-15 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); CRC cis rs9814567 0.806 rs4955526 chr3:134317337 A/G cg06109529 chr3:134205091 CEP63;ANAPC13 -0.69 -10.29 -0.49 1e-21 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs847577 0.722 rs7790120 chr7:97712831 C/A cg00277769 chr7:97922759 BAIAP2L1 -0.42 -7.06 -0.36 1.01e-11 Breast cancer; CRC cis rs6740322 0.748 rs13420649 chr2:43463637 T/C cg06169590 chr2:43455088 ZFP36L2;LOC100129726 -0.69 -8.56 -0.43 4.28e-16 Coronary artery disease; CRC cis rs2075371 1.000 rs2058976 chr7:133981379 G/T cg11752832 chr7:134001865 SLC35B4 0.48 7.39 0.38 1.24e-12 Mean platelet volume; CRC cis rs34375054 0.526 rs34764657 chr12:125679639 A/G cg06987292 chr12:125626746 AACS -0.37 -5.76 -0.3 1.95e-8 Post bronchodilator FEV1/FVC ratio; CRC cis rs9488822 0.676 rs3798227 chr6:116324898 A/G cg18764771 chr6:116381957 FRK 0.25 7.0 0.36 1.42e-11 Cholesterol, total;LDL cholesterol; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg17885091 chr1:68299057 GNG12 0.37 6.08 0.32 3.42e-9 Liver disease severity in Alagille syndrome; CRC cis rs12477438 0.520 rs6542863 chr2:99725138 C/T cg14399236 chr2:99771627 LIPT1;TSGA10 0.82 14.36 0.62 1.21e-36 Chronic sinus infection; CRC cis rs853679 0.599 rs188015 chr6:27877446 T/A cg19041857 chr6:27730383 NA -0.59 -5.78 -0.3 1.71e-8 Depression; CRC cis rs34864796 0.547 rs200476 chr6:27768348 A/T cg03623178 chr6:28175578 NA 0.57 6.72 0.35 8.03e-11 Lung function (FEV1);Lung function (FEV1/FVC);Lung function (FVC); CRC cis rs8060686 0.641 rs8060893 chr16:68191608 A/T cg26727032 chr16:67993705 SLC12A4 -0.55 -6.26 -0.33 1.22e-9 HDL cholesterol;Metabolic syndrome; CRC cis rs7705042 0.865 rs6580225 chr5:141489381 G/C cg07392085 chr5:141489673 NDFIP1 0.46 7.2 0.37 4.04e-12 Asthma; CRC cis rs9916302 0.904 rs12952384 chr17:37669536 T/C cg00129232 chr17:37814104 STARD3 -0.54 -8.18 -0.41 6.31e-15 Glomerular filtration rate (creatinine); CRC cis rs4363385 0.747 rs6587716 chr1:152966705 C/T cg25856811 chr1:152973957 SPRR3 -0.26 -7.41 -0.38 1.1e-12 Inflammatory skin disease; CRC cis rs2067615 0.560 rs10861671 chr12:107220927 T/C cg13491945 chr12:107078410 RFX4 0.35 5.92 0.31 7.88e-9 Heart rate; CRC cis rs2880765 0.566 rs11630381 chr15:86012503 A/G cg10818794 chr15:86012489 AKAP13 -0.51 -7.96 -0.4 2.72e-14 Coronary artery disease; CRC trans rs1814175 0.619 rs10769623 chr11:49865926 C/T cg11707556 chr5:10655725 ANKRD33B -0.51 -9.67 -0.47 1.25e-19 Height; CRC cis rs6502050 0.835 rs4789744 chr17:80101506 A/C cg25804541 chr17:80189381 SLC16A3 -0.31 -5.97 -0.31 6.08e-9 Life satisfaction; CRC cis rs2404602 1.000 rs2404602 chr15:77030792 A/G cg23625390 chr15:77176239 SCAPER 0.55 8.4 0.42 1.37e-15 Blood metabolite levels; CRC cis rs2204008 0.614 rs4578492 chr12:38036350 T/C cg26384229 chr12:38710491 ALG10B 0.68 9.03 0.45 1.48e-17 Bladder cancer; CRC trans rs10802346 0.545 rs10924545 chr1:246364592 C/T cg22732515 chr19:44031385 ETHE1 -0.7 -10.8 -0.51 1.76e-23 Fractional exhaled nitric oxide (childhood); CRC cis rs4920343 0.698 rs591009 chr1:19086869 A/G cg19637330 chr1:19110922 NA 0.39 5.82 0.31 1.39e-8 Knee osteoarthritis; CRC cis rs7772486 0.686 rs857877 chr6:145976230 A/C cg13319975 chr6:146136371 FBXO30 0.45 6.75 0.35 6.77e-11 Lobe attachment (rater-scored or self-reported); CRC cis rs4319547 0.585 rs7953007 chr12:122816977 A/C cg23029597 chr12:123009494 RSRC2 -0.51 -6.19 -0.32 1.76e-9 Body mass index; CRC cis rs926938 0.583 rs12401670 chr1:115244337 C/T cg12756093 chr1:115239321 AMPD1 -0.66 -9.21 -0.45 3.82e-18 Autism; CRC cis rs9463078 0.527 rs2040032 chr6:44743009 C/T cg25276700 chr6:44698697 NA 0.3 7.76 0.39 1.09e-13 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; CRC cis rs62064224 0.606 rs61390192 chr17:30837447 C/T cg18200150 chr17:30822561 MYO1D 0.63 11.84 0.55 3.3699999999999996e-27 Schizophrenia; CRC cis rs1865721 0.771 rs7235563 chr18:73139335 C/G cg26385618 chr18:73139727 C18orf62 -0.38 -5.69 -0.3 2.83e-8 Intelligence; CRC cis rs600806 0.850 rs12073497 chr1:109974450 A/C cg23032129 chr1:109941072 SORT1 -0.29 -5.88 -0.31 1.03e-8 Intelligence (multi-trait analysis); CRC cis rs7618915 0.547 rs11130323 chr3:52770277 T/C cg11645453 chr3:52864694 ITIH4 0.35 6.0 0.31 5.2e-9 Bipolar disorder; CRC cis rs10463316 0.894 rs7729216 chr5:150762277 A/G cg03212797 chr5:150827313 SLC36A1 -0.5 -7.78 -0.39 9.41e-14 Metabolite levels (Pyroglutamine); CRC cis rs11105298 0.891 rs10858851 chr12:89830870 C/T cg08166232 chr12:89918718 WDR51B;GALNT4 -0.61 -7.67 -0.39 2.02e-13 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; CRC cis rs12048904 0.505 rs4517368 chr1:101255052 C/T cg16556008 chr1:101360663 SLC30A7;EXTL2 -0.79 -11.85 -0.55 3.23e-27 Multiple sclerosis; CRC cis rs910316 0.967 rs8007539 chr14:75664953 T/C cg03030879 chr14:75389066 RPS6KL1 0.41 6.41 0.33 5.09e-10 Height; CRC cis rs736801 0.780 rs12521868 chr5:131784393 A/C cg12564285 chr5:131593104 PDLIM4 -0.33 -5.76 -0.3 1.9e-8 Breast cancer;Mosquito bite size; CRC cis rs6724607 1.000 rs4321393 chr2:191452899 G/T cg27211696 chr2:191398769 TMEM194B 0.41 6.03 0.32 4.47e-9 Pulse pressure; CRC cis rs12024301 0.557 rs6692924 chr1:183624098 G/T cg11505048 chr1:183622726 RGL1;APOBEC4 0.81 7.0 0.36 1.42e-11 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs3126085 1.000 rs12567463 chr1:152180128 T/A cg09127314 chr1:152161683 NA -0.51 -5.91 -0.31 8.47e-9 Atopic dermatitis; CRC cis rs13191362 1.000 rs13207239 chr6:163008772 A/C cg06582575 chr6:163149167 PACRG;PARK2 0.75 10.22 0.49 1.85e-21 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs6123683 1.000 rs6123683 chr20:55824509 A/G cg13236649 chr20:55835020 BMP7 0.43 6.14 0.32 2.4e-9 Facial morphology (factor 5, width of mouth relative to central midface); CRC cis rs7811142 1.000 rs112317829 chr7:100043173 A/G cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.14 17.63 0.7 1.96e-49 Platelet count; CRC cis rs701145 0.556 rs355756 chr3:154021063 G/A cg16511985 chr3:153974050 SGEF 0.43 5.76 0.3 1.91e-8 Coronary artery disease; CRC cis rs7208859 0.623 rs11657662 chr17:29076347 A/G cg13385521 chr17:29058706 SUZ12P -0.74 -8.44 -0.42 1.05e-15 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs7044106 0.762 rs7024046 chr9:123419178 G/A cg14255062 chr9:123606675 PSMD5;LOC253039 0.44 6.52 0.34 2.61e-10 Hip circumference adjusted for BMI; CRC cis rs992157 0.560 rs1514132 chr2:219084082 C/T cg00012203 chr2:219082015 ARPC2 -0.54 -8.42 -0.42 1.2e-15 Colorectal cancer; CRC cis rs3849570 0.695 rs6809528 chr3:81872048 A/C cg07356753 chr3:81810745 GBE1 -0.44 -5.79 -0.3 1.6e-8 Waist circumference;Body mass index; CRC cis rs6951245 1.000 rs11768761 chr7:1069807 A/G cg21664854 chr7:1097933 C7orf50;GPR146 0.79 8.92 0.44 3.39e-17 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs807029 0.533 rs67692077 chr10:102740271 T/C cg04662943 chr10:102668895 NA 0.65 7.5 0.38 6.11e-13 Ejection fraction in Tripanosoma cruzi seropositivity; CRC cis rs55702914 0.935 rs56116936 chr2:198219217 C/A cg10820045 chr2:198174542 NA 0.36 6.38 0.33 5.99e-10 Major depression and alcohol dependence; CRC cis rs10256972 0.567 rs2960835 chr7:1202963 A/G cg09177884 chr7:1199841 ZFAND2A -0.5 -7.43 -0.38 9.17e-13 Longevity;Endometriosis; CRC cis rs9896933 0.830 rs607544 chr17:80768760 C/G cg15369054 chr17:80825471 TBCD 0.52 6.19 0.32 1.76e-9 Bone mineral accretion in asthma (oral corticosteroid dose interaction); CRC cis rs10504229 0.562 rs2014516 chr8:58128288 C/A cg21724239 chr8:58056113 NA 0.49 6.81 0.35 4.75e-11 Developmental language disorder (linguistic errors); CRC cis rs763121 0.853 rs5995610 chr22:39064681 C/T cg06544989 chr22:39130855 UNC84B 0.46 7.11 0.37 7.19e-12 Menopause (age at onset); CRC cis rs751728 0.687 rs943479 chr6:33752013 A/G cg25922239 chr6:33757077 LEMD2 0.46 6.86 0.35 3.48e-11 Crohn's disease; CRC cis rs2440129 0.611 rs1126667 chr17:6902760 C/T cg21237687 chr17:6899380 ALOX12 -0.61 -11.57 -0.54 3.41e-26 Tonsillectomy; CRC cis rs704795 0.902 rs11887784 chr2:27679919 A/G cg17158414 chr2:27665306 KRTCAP3 -0.29 -6.21 -0.32 1.63e-9 Menopause (age at onset); CRC cis rs10504229 0.683 rs7816733 chr8:58129855 G/A cg04204079 chr8:58130323 NA -0.45 -5.78 -0.3 1.71e-8 Developmental language disorder (linguistic errors); CRC cis rs995000 0.965 rs1979722 chr1:62940097 G/A cg19896129 chr1:63156450 NA 0.4 5.84 0.31 1.28e-8 Triglyceride levels; CRC cis rs7647973 0.626 rs4855846 chr3:49683526 G/A cg13072238 chr3:49761600 GMPPB -0.52 -5.92 -0.31 8.06e-9 Menarche (age at onset); CRC trans rs1167827 1.000 rs1167827 chr7:75163169 A/G cg07504079 chr7:72649617 NCF1B -0.45 -7.01 -0.36 1.39e-11 Body mass index;BMI (adjusted for smoking behaviour);BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs1008375 1.000 rs12648232 chr4:17612537 C/T cg16339924 chr4:17578868 LAP3 -0.47 -6.15 -0.32 2.26e-9 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs898097 0.625 rs6502017 chr17:80891135 C/T cg19046167 chr17:80928561 B3GNTL1 0.44 7.46 0.38 7.74e-13 Breast cancer; CRC cis rs7917772 0.619 rs2251772 chr10:104470918 T/C cg22532475 chr10:104410764 TRIM8 -0.43 -6.91 -0.36 2.54e-11 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC cis rs2486012 0.850 rs2906462 chr1:44332084 G/A cg12908607 chr1:44402522 ARTN -0.42 -5.76 -0.3 1.91e-8 Intelligence (multi-trait analysis); CRC cis rs13108904 0.967 rs11247987 chr4:1294532 G/A cg19318889 chr4:1322082 MAEA 0.4 5.72 0.3 2.39e-8 Obesity-related traits; CRC cis rs11758351 0.866 rs55815656 chr6:26207303 G/A cg10723962 chr6:26240782 HIST1H4F -0.38 -6.28 -0.33 1.05e-9 Gout;Renal underexcretion gout; CRC cis rs10479542 0.583 rs4131080 chr5:179044292 G/A cg14820908 chr5:178986412 RUFY1 0.37 5.92 0.31 8.18e-9 Lung cancer; CRC cis rs367615 0.704 rs4286723 chr5:108835959 G/A cg17395555 chr5:108820864 NA 0.47 9.49 0.46 4.77e-19 Colorectal cancer (SNP x SNP interaction); CRC cis rs6893807 0.667 rs1477290 chr5:87988934 T/C cg09002922 chr5:87956389 LOC645323 -0.43 -5.61 -0.3 4.23e-8 Body mass index; CRC cis rs2976388 0.590 rs10087426 chr8:143814554 G/A cg05569086 chr8:143859399 LYNX1 -0.39 -6.39 -0.33 5.59e-10 Urinary tract infection frequency; CRC cis rs4665809 0.590 rs3806515 chr2:26466975 C/T cg22920501 chr2:26401640 FAM59B 0.83 11.96 0.55 1.28e-27 Gut microbiome composition (summer); CRC cis rs6543140 0.572 rs17027173 chr2:103057043 G/A cg09003973 chr2:102972529 NA 0.53 6.67 0.35 1.1e-10 Blood protein levels; CRC cis rs3768617 0.510 rs10797852 chr1:183101302 C/T ch.1.3577855R chr1:183094577 LAMC1 0.89 15.61 0.65 1.71e-41 Fuchs's corneal dystrophy; CRC cis rs9341808 0.700 rs12215236 chr6:80975058 A/T cg08355045 chr6:80787529 NA 0.39 6.4 0.33 5.2e-10 Sitting height ratio; CRC cis rs9522267 0.535 rs914031 chr13:112240176 C/A cg14352298 chr13:112236639 NA 0.29 6.49 0.34 3.25e-10 Hepatitis; CRC cis rs9457247 1.000 rs422094 chr6:167397033 C/G cg23791538 chr6:167370224 RNASET2 -0.38 -5.97 -0.31 6.14e-9 Crohn's disease; CRC trans rs7395662 0.611 rs7478698 chr11:48549139 T/C cg15704280 chr7:45808275 SEPT13 -0.48 -6.83 -0.35 4.14e-11 HDL cholesterol; CRC cis rs6121246 0.909 rs6060644 chr20:30265652 G/A cg07809909 chr20:30433512 FOXS1 0.35 5.7 0.3 2.6e-8 Mean corpuscular hemoglobin; CRC cis rs644799 0.965 rs10831425 chr11:95500628 T/C cg25622487 chr11:95524042 FAM76B;CEP57 0.75 11.32 0.53 2.57e-25 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs1862618 0.802 rs832547 chr5:56183941 C/G cg18230493 chr5:56204884 C5orf35 -0.75 -9.27 -0.45 2.61e-18 Initial pursuit acceleration; CRC cis rs1267303 0.537 rs59935547 chr1:47001423 A/G cg25110126 chr1:46999211 NA 0.57 8.59 0.43 3.61e-16 Monobrow; CRC cis rs9487051 0.872 rs1111866 chr6:109610846 A/C cg12927641 chr6:109611667 NA 0.37 6.66 0.34 1.17e-10 Reticulocyte fraction of red cells; CRC cis rs2882667 0.898 rs6867343 chr5:138374428 C/T cg04439458 chr5:138467593 SIL1 -0.33 -5.98 -0.31 5.91e-9 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs6662572 0.737 rs6680647 chr1:46345478 C/T cg08644498 chr1:46502608 NA 0.45 7.07 0.36 9.47e-12 Blood protein levels; CRC cis rs10256972 0.577 rs6962809 chr7:1208889 A/G cg03188948 chr7:1209495 NA 0.61 9.26 0.45 2.63e-18 Longevity;Endometriosis; CRC cis rs11677370 0.603 rs10198219 chr2:3854600 T/C cg17052675 chr2:3827356 NA -0.67 -11.12 -0.52 1.34e-24 Type 2 diabetes; CRC cis rs8177253 0.965 rs7638018 chr3:133495461 C/T cg11941060 chr3:133502564 NA 0.57 9.75 0.47 6.71e-20 Iron status biomarkers; CRC cis rs9311474 0.607 rs13076398 chr3:52573096 G/A cg15147215 chr3:52552868 STAB1 -0.68 -12.03 -0.55 7.29e-28 Electroencephalogram traits; CRC cis rs2840044 1.000 rs8073935 chr17:33985849 C/T cg05299278 chr17:33885742 SLFN14 0.41 6.12 0.32 2.7e-9 Response to radiotherapy in cancer (late toxicity); CRC cis rs7727544 0.507 rs11741341 chr5:131570218 A/G cg09877947 chr5:131593287 PDLIM4 0.52 9.52 0.46 3.88e-19 Blood metabolite levels; CRC cis rs6942756 0.774 rs2566876 chr7:128890055 A/G cg02491457 chr7:128862824 NA 0.66 8.97 0.44 2.28e-17 White matter hyperintensity burden; CRC cis rs2404618 0.506 rs12156177 chr8:1493684 C/T cg02903104 chr8:1507517 DLGAP2 0.35 6.13 0.32 2.46e-9 Lung cancer; CRC cis rs6432018 1.000 rs10210225 chr2:9739225 A/G cg12832956 chr2:9616023 IAH1 -0.38 -5.69 -0.3 2.8e-8 Heart rate variability traits; CRC cis rs776905 0.598 rs491098 chr13:113769346 C/G cg09069900 chr13:113776964 F10 0.4 6.52 0.34 2.7e-10 Blood protein levels; CRC cis rs7772486 0.790 rs11760 chr6:146205973 G/T cg23711669 chr6:146136114 FBXO30 0.71 12.49 0.57 1.42e-29 Lobe attachment (rater-scored or self-reported); CRC cis rs7760949 0.889 rs9475806 chr6:13934527 A/G cg27413430 chr6:13925136 RNF182 0.34 5.88 0.31 1.01e-8 Mean corpuscular hemoglobin concentration; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg16467105 chr14:74959227 NPC2;ISCA2 0.48 6.71 0.35 8.41e-11 Thyroid stimulating hormone; CRC cis rs9287719 0.967 rs12995602 chr2:10753542 C/A cg00105475 chr2:10696890 NA 0.45 7.17 0.37 4.85e-12 Prostate cancer; CRC cis rs9372498 0.536 rs17080292 chr6:118850266 A/G cg15382696 chr6:118971807 C6orf204 0.61 8.02 0.4 1.92e-14 Diastolic blood pressure; CRC cis rs365302 0.628 rs409096 chr6:159610904 T/C cg14500486 chr6:159655392 FNDC1 0.59 8.5 0.42 6.63e-16 Coronary heart disease; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg05193570 chr5:893022 TRIP13;BRD9 0.39 6.02 0.31 4.62e-9 Liver disease severity in Alagille syndrome; CRC cis rs7553864 0.518 rs10747341 chr1:87627331 G/A cg02083836 chr1:87617350 LOC339524 0.63 10.98 0.52 4.33e-24 Smoking behavior; CRC cis rs13108904 0.870 rs2291199 chr4:1244267 A/G cg00684032 chr4:1343700 KIAA1530 0.43 6.41 0.33 5.07e-10 Obesity-related traits; CRC cis rs897984 0.683 rs12926237 chr16:30837596 C/T cg00531865 chr16:30841666 NA 0.51 7.43 0.38 9.14e-13 Dementia with Lewy bodies; CRC cis rs2032447 0.839 rs6901039 chr6:26000885 A/C cg26028573 chr6:26043587 HIST1H2BB 0.46 6.94 0.36 2.11e-11 Intelligence (multi-trait analysis); CRC cis rs853679 0.542 rs9380063 chr6:28137853 A/G cg15786705 chr6:28176104 NA 0.78 9.83 0.48 3.57e-20 Depression; CRC cis rs853679 0.542 rs34131763 chr6:28075000 A/C cg21251018 chr6:28226885 NKAPL 0.48 6.26 0.33 1.17e-9 Depression; CRC cis rs72634258 0.836 rs9658012 chr1:7989022 C/T cg00042356 chr1:8021962 PARK7 0.65 6.55 0.34 2.28e-10 Inflammatory bowel disease; CRC cis rs7493 0.853 rs17166879 chr7:95053415 A/G cg01874867 chr7:94954059 PON1 -0.52 -6.46 -0.34 3.79e-10 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs6840360 1.000 rs1877187 chr4:152605621 C/T cg09659197 chr4:152720779 NA 0.5 10.93 0.52 6.33e-24 Intelligence (multi-trait analysis); CRC trans rs7726839 0.718 rs6887972 chr5:597274 C/G cg25482853 chr8:67687455 SGK3 0.71 8.91 0.44 3.53e-17 Obesity-related traits; CRC cis rs9325144 0.555 rs4550281 chr12:38689937 A/G cg26384229 chr12:38710491 ALG10B 0.58 8.54 0.43 5.04e-16 Morning vs. evening chronotype; CRC cis rs11958404 0.932 rs72816584 chr5:157433190 G/A cg05962755 chr5:157440814 NA 1.01 12.88 0.58 5.12e-31 IgG glycosylation; CRC cis rs853679 0.517 rs9295759 chr6:28124469 C/T cg18032046 chr6:28092343 ZSCAN16 -0.51 -5.93 -0.31 7.47e-9 Depression; CRC cis rs11098499 0.569 rs10023641 chr4:120258410 C/G cg24375607 chr4:120327624 NA 0.47 7.66 0.39 2.13e-13 Corneal astigmatism; CRC cis rs6694672 0.867 rs518149 chr1:197188664 A/G cg13682187 chr1:196946512 CFHR5 0.49 6.92 0.36 2.31e-11 Asthma; CRC cis rs28386778 0.829 rs1877317 chr17:61776479 T/C cg06873352 chr17:61820015 STRADA 0.78 14.07 0.61 1.52e-35 Prudent dietary pattern; CRC cis rs9715521 0.900 rs6551646 chr4:59824827 A/G cg11281224 chr4:60001000 NA -0.4 -5.9 -0.31 9.03e-9 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs7586879 0.828 rs1865688 chr2:25108245 C/G cg04586622 chr2:25135609 ADCY3 -0.58 -9.95 -0.48 1.42e-20 Body mass index; CRC cis rs11252926 0.574 rs10904065 chr10:423226 G/T cg18196295 chr10:418757 DIP2C -0.67 -9.32 -0.46 1.7e-18 Psychosis in Alzheimer's disease; CRC cis rs1799949 0.965 rs8176161 chr17:41241390 C/A cg01879757 chr17:41196368 BRCA1 -0.42 -6.33 -0.33 7.99e-10 Menopause (age at onset); CRC trans rs17685 0.587 rs1623759 chr7:75724679 A/T cg19862616 chr7:65841803 NCRNA00174 1.0 18.87 0.72 2.33e-54 Coffee consumption;Coffee consumption (cups per day); CRC cis rs875971 0.522 rs6960048 chr7:65408039 A/G cg18876405 chr7:65276391 NA 0.65 12.06 0.55 5.61e-28 Aortic root size; CRC cis rs2976388 0.609 rs2585144 chr8:143800269 A/T cg04969067 chr8:143858791 LYNX1 0.44 7.43 0.38 9.31e-13 Urinary tract infection frequency; CRC cis rs7659604 1.000 rs10005932 chr4:122664782 T/C cg06713675 chr4:122721982 EXOSC9 -0.38 -6.19 -0.32 1.76e-9 Type 2 diabetes; CRC cis rs2404602 0.647 rs11072631 chr15:77132909 T/C cg23625390 chr15:77176239 SCAPER -0.86 -13.02 -0.58 1.57e-31 Blood metabolite levels; CRC cis rs758324 0.773 rs13174385 chr5:131160187 T/G cg25547332 chr5:131281432 NA 0.37 5.93 0.31 7.56e-9 Alzheimer's disease in APOE e4- carriers; CRC cis rs1218582 0.740 rs1977879 chr1:154879743 G/A cg24250549 chr1:154909240 PMVK 0.65 11.29 0.53 3.2e-25 Prostate cancer; CRC cis rs262150 1.000 rs262149 chr7:158778256 A/G cg12590608 chr7:158785262 NA -0.44 -7.91 -0.4 4e-14 Facial morphology (factor 20); CRC cis rs12477438 0.798 rs10167015 chr2:99570707 C/T cg26064155 chr2:99771622 LIPT1;TSGA10 -0.71 -10.05 -0.48 6.65e-21 Chronic sinus infection; CRC trans rs1005277 0.541 rs1740741 chr10:38515334 C/T cg27523141 chr10:43048294 ZNF37B 0.47 6.9 0.36 2.69e-11 Extrinsic epigenetic age acceleration; CRC cis rs208520 0.690 rs851468 chr6:66825875 G/A cg07460842 chr6:66804631 NA -1.09 -15.06 -0.64 2.3e-39 Exhaled nitric oxide output; CRC cis rs10751667 0.621 rs11246345 chr11:934924 T/C cg23136738 chr11:925521 AP2A2 -0.41 -6.78 -0.35 5.53e-11 Alzheimer's disease (late onset); CRC cis rs9303401 0.573 rs35104446 chr17:57180234 A/C cg10487724 chr17:56770010 TEX14;RAD51C 0.68 8.4 0.42 1.39e-15 Cognitive test performance; CRC trans rs6550704 0.687 rs9865314 chr3:22634337 A/G cg06395988 chr2:242041550 MTERFD2 -0.42 -6.06 -0.32 3.82e-9 Daytime sleep phenotypes; CRC cis rs863345 0.604 rs6670343 chr1:158497258 A/T cg12129480 chr1:158549410 OR10X1 -0.29 -5.95 -0.31 6.94e-9 Pneumococcal bacteremia; CRC cis rs6088580 0.561 rs3761147 chr20:32996689 G/T cg24642439 chr20:33292090 TP53INP2 -0.36 -6.15 -0.32 2.24e-9 Glomerular filtration rate (creatinine); CRC cis rs2839186 0.564 rs4819215 chr21:47623573 G/A cg13126279 chr21:47581558 C21orf56 -0.4 -6.35 -0.33 7.35e-10 Testicular germ cell tumor; CRC cis rs11864453 0.786 rs1050362 chr16:72130815 C/A cg01557791 chr16:72042693 DHODH -0.47 -6.59 -0.34 1.76e-10 Fibrinogen levels; CRC cis rs7827545 1.000 rs4909910 chr8:135565201 T/C cg07299736 chr8:135490787 ZFAT -0.37 -6.19 -0.32 1.81e-9 Hypertension (SNP x SNP interaction); CRC cis rs6540556 0.678 rs11119330 chr1:209889659 A/G cg05527609 chr1:210001259 C1orf107 -0.56 -5.88 -0.31 1.01e-8 Red blood cell count; CRC cis rs6502050 0.835 rs35192339 chr17:80119106 G/A cg09264619 chr17:80180166 NA -0.35 -5.93 -0.31 7.47e-9 Life satisfaction; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg07067904 chr2:74425934 MTHFD2 0.38 6.19 0.32 1.84e-9 Liver disease severity in Alagille syndrome; CRC cis rs6684514 1.000 rs12563631 chr1:156258953 T/C cg16558208 chr1:156270281 VHLL 0.57 8.94 0.44 2.95e-17 Mean corpuscular hemoglobin concentration;Glycated hemoglobin levels; CRC cis rs9399137 0.507 rs7768278 chr6:135274957 T/C cg24558204 chr6:135376177 HBS1L 0.62 9.09 0.45 9.79e-18 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; CRC cis rs514406 0.861 rs12141260 chr1:53300127 C/T cg24675658 chr1:53192096 ZYG11B -0.55 -8.29 -0.42 2.89e-15 Monocyte count; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg13393195 chr12:113659153 TPCN1;IQCD 0.43 6.02 0.31 4.6e-9 Response to antipsychotic treatment; CRC cis rs2842992 0.724 rs15982 chr6:160199687 T/C cg19482086 chr6:160211437 TCP1;MRPL18 0.81 13.22 0.59 2.6e-32 Age-related macular degeneration (geographic atrophy); CRC cis rs6459804 0.588 rs78762416 chr7:157511142 G/A cg15733309 chr7:157513707 PTPRN2 0.42 6.85 0.35 3.69e-11 Bipolar disorder and schizophrenia; CRC cis rs2075371 0.863 rs12672691 chr7:133954431 C/T cg02659138 chr7:134003124 SLC35B4 0.39 6.63 0.34 1.41e-10 Mean platelet volume; CRC cis rs6952808 0.929 rs12667688 chr7:1931030 C/T cg02951883 chr7:2050386 MAD1L1 -0.73 -11.62 -0.54 2.14e-26 Bipolar disorder and schizophrenia; CRC cis rs12545109 0.800 rs2576599 chr8:57388410 G/A cg09654669 chr8:57350985 NA -0.42 -5.9 -0.31 8.98e-9 Obesity-related traits; CRC cis rs10256972 0.630 rs13235747 chr7:1129123 T/C cg16145915 chr7:1198662 ZFAND2A -0.4 -7.9 -0.4 4.23e-14 Longevity;Endometriosis; CRC cis rs875971 0.929 rs778712 chr7:65849978 C/T cg00343986 chr7:65444356 GUSB 0.43 6.3 0.33 9.66e-10 Aortic root size; CRC trans rs45509595 0.841 rs9368531 chr6:27781872 G/C cg16898833 chr6:26189333 HIST1H4D 0.72 6.46 0.34 3.84e-10 Breast cancer; CRC cis rs7940866 0.903 rs10791109 chr11:130850377 A/C cg12179176 chr11:130786555 SNX19 0.56 8.37 0.42 1.68e-15 Schizophrenia; CRC cis rs2033711 0.870 rs7259841 chr19:58951123 T/C cg00825309 chr19:58991885 ZNF446 -0.44 -6.31 -0.33 9.13e-10 Uric acid clearance; CRC cis rs7786877 0.761 rs11772705 chr7:100298904 T/C cg16850897 chr7:100343110 ZAN -0.58 -8.97 -0.44 2.3e-17 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs1552244 1.000 rs35993975 chr3:10067794 A/G cg08888203 chr3:10149979 C3orf24 0.68 8.09 0.41 1.19e-14 Alzheimer's disease; CRC cis rs10504229 0.683 rs903702 chr8:58128557 T/C cg22535103 chr8:58192502 C8orf71 -0.7 -9.34 -0.46 1.47e-18 Developmental language disorder (linguistic errors); CRC trans rs2243480 1.000 rs6958420 chr7:65751171 A/G cg10756647 chr7:56101905 PSPH -0.77 -7.87 -0.4 5.06e-14 Diabetic kidney disease; CRC cis rs9487051 0.714 rs9386797 chr6:109632520 C/A cg12927641 chr6:109611667 NA -0.36 -6.38 -0.33 6.1e-10 Reticulocyte fraction of red cells; CRC cis rs6500602 0.826 rs11076831 chr16:4460133 A/G cg14951292 chr16:4525986 HMOX2;NMRAL1 -0.66 -8.38 -0.42 1.51e-15 Schizophrenia; CRC trans rs7765175 0.547 rs1066296 chr6:113572558 A/C cg10503028 chr9:127615433 WDR38 0.46 6.13 0.32 2.45e-9 Coronary artery calcification; CRC cis rs1448094 0.802 rs11513957 chr12:86435551 C/T cg02569458 chr12:86230093 RASSF9 0.39 6.32 0.33 8.64e-10 Major depressive disorder; CRC trans rs17685 0.753 rs55812043 chr7:75747241 T/C cg19862616 chr7:65841803 NCRNA00174 0.98 17.88 0.7 1.96e-50 Coffee consumption;Coffee consumption (cups per day); CRC cis rs735539 0.645 rs3825444 chr13:21173926 A/G cg27499820 chr13:21296301 IL17D 0.41 5.91 0.31 8.36e-9 Dental caries; CRC cis rs6952808 1.000 rs4719319 chr7:1888094 G/A cg21782813 chr7:2030301 MAD1L1 0.45 7.52 0.38 5.16e-13 Bipolar disorder and schizophrenia; CRC cis rs2479724 0.776 rs2250428 chr6:41832772 T/A cg17623882 chr6:41773611 USP49 -0.52 -8.69 -0.43 1.76e-16 Menarche (age at onset); CRC cis rs896854 0.846 rs2340584 chr8:95916811 A/G cg23172400 chr8:95962367 TP53INP1 -0.45 -7.39 -0.38 1.21e-12 Type 2 diabetes; CRC trans rs17641971 0.862 rs341829 chr8:50005758 T/C cg18784943 chr17:79371681 NA 0.41 6.4 0.33 5.27e-10 Blood metabolite levels; CRC trans rs1997103 1.000 rs6949222 chr7:55411264 C/T cg20935933 chr6:143382018 AIG1 0.51 6.65 0.34 1.25e-10 QRS interval (sulfonylurea treatment interaction); CRC cis rs7223966 1.000 rs8069687 chr17:61883023 C/T cg23090583 chr17:61904693 PSMC5;FTSJ3 -0.52 -6.37 -0.33 6.25e-10 Hip circumference adjusted for BMI;Body mass index; CRC cis rs6860806 0.507 rs272892 chr5:131664349 C/T cg18758796 chr5:131593413 PDLIM4 0.39 6.3 0.33 9.75e-10 Breast cancer; CRC cis rs3749237 0.595 rs7621003 chr3:49411404 T/C cg07636037 chr3:49044803 WDR6 0.55 8.1 0.41 1.08e-14 Resting heart rate; CRC cis rs1451375 0.698 rs11238226 chr7:50645827 A/G cg18232548 chr7:50535776 DDC 0.44 6.33 0.33 8.03e-10 Malaria; CRC trans rs1814175 0.817 rs1988416 chr11:49932324 G/A cg11707556 chr5:10655725 ANKRD33B -0.44 -8.31 -0.42 2.52e-15 Height; CRC cis rs7914558 1.000 rs67908413 chr10:104764989 T/C cg04362960 chr10:104952993 NT5C2 0.6 9.09 0.45 9.25e-18 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs720844 0.748 rs35076661 chr2:149319685 T/G cg09247360 chr2:149335327 NA -0.55 -6.03 -0.32 4.29e-9 Peripheral arterial disease (traffic-related air pollution interaction); CRC trans rs875971 0.545 rs4718364 chr7:66001340 C/A cg02869306 chr7:64672164 INTS4L1 -0.44 -6.39 -0.33 5.78e-10 Aortic root size; CRC cis rs2404602 0.716 rs1125932 chr15:76820540 C/T cg23625390 chr15:77176239 SCAPER 0.48 6.93 0.36 2.28e-11 Blood metabolite levels; CRC cis rs4713118 0.911 rs2394000 chr6:27686991 A/G cg12172441 chr6:28176163 NA 0.49 6.42 0.33 4.77e-10 Parkinson's disease; CRC cis rs995000 0.931 rs1748199 chr1:63057136 T/C cg19896129 chr1:63156450 NA 0.42 6.53 0.34 2.48e-10 Triglyceride levels; CRC cis rs644799 0.965 rs2950522 chr11:95524719 C/T cg03916912 chr11:95522834 CEP57;FAM76B 0.94 17.8 0.7 4.17e-50 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs4332037 0.950 rs62442895 chr7:1936938 G/A cg24505167 chr7:1915268 MAD1L1 -0.43 -6.02 -0.31 4.68e-9 Bipolar disorder; CRC trans rs916888 0.531 rs183211 chr17:44788310 G/A cg10053473 chr17:62856997 LRRC37A3 -0.66 -8.89 -0.44 4.02e-17 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs1707322 1.000 rs4074225 chr1:46392364 G/C cg03146154 chr1:46216737 IPP 0.58 8.14 0.41 8.5e-15 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs1005277 0.579 rs2472176 chr10:38382921 T/C cg00409905 chr10:38381863 ZNF37A -0.68 -11.31 -0.53 2.89e-25 Extrinsic epigenetic age acceleration; CRC cis rs17826219 0.500 rs9891256 chr17:29072692 C/T cg13385521 chr17:29058706 SUZ12P 0.71 8.1 0.41 1.05e-14 Body mass index; CRC cis rs9291683 0.588 rs34501273 chr4:9996996 C/T cg11266682 chr4:10021025 SLC2A9 0.48 10.31 0.49 8.97e-22 Bone mineral density; CRC cis rs7493 0.755 rs2375001 chr7:94964640 A/T cg17330251 chr7:94953956 PON1 -0.5 -6.44 -0.33 4.24e-10 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs11122272 0.701 rs2486725 chr1:231540288 G/C cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.59 -8.84 -0.44 6.02e-17 Hemoglobin concentration; CRC cis rs7811142 1.000 rs7811142 chr7:100065443 A/T cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.17 17.51 0.69 5.94e-49 Platelet count; CRC cis rs4654899 1.000 rs6697555 chr1:21287938 C/T cg02927042 chr1:21476669 EIF4G3 -0.45 -7.23 -0.37 3.33e-12 Superior frontal gyrus grey matter volume; CRC cis rs73206853 0.686 rs73194039 chr12:111179153 C/T cg12870014 chr12:110450643 ANKRD13A 0.66 6.29 0.33 1.01e-9 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC cis rs4713118 0.869 rs9366700 chr6:27696951 C/T cg19041857 chr6:27730383 NA -0.41 -6.0 -0.31 5.3300000000000004e-09 Parkinson's disease; CRC cis rs6952808 0.635 rs12154473 chr7:1982181 A/G cg14004847 chr7:1930337 MAD1L1 0.44 6.35 0.33 7.29e-10 Bipolar disorder and schizophrenia; CRC cis rs28386778 0.897 rs11079510 chr17:61820902 T/C cg11494091 chr17:61959527 GH2 0.6 10.33 0.49 7.37e-22 Prudent dietary pattern; CRC trans rs7618501 1.000 rs2234391 chr3:49842625 A/G cg21582582 chr3:182698605 DCUN1D1 0.53 7.84 0.4 6.34e-14 Intelligence (multi-trait analysis); CRC cis rs12048904 0.505 rs4517368 chr1:101255052 C/T cg00063077 chr1:101360652 SLC30A7;EXTL2 -0.64 -9.02 -0.45 1.57e-17 Multiple sclerosis; CRC cis rs9914988 0.943 rs9915673 chr17:27132893 G/C cg16670446 chr17:27188758 MIR451;MIR144 0.55 8.52 0.43 5.75e-16 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs12586317 0.547 rs74462850 chr14:35500093 G/T cg05294307 chr14:35346193 BAZ1A -0.69 -7.47 -0.38 7.35e-13 Psoriasis; CRC cis rs7777484 0.534 rs2258709 chr7:2832365 C/T cg19717773 chr7:2847554 GNA12 0.47 8.19 0.41 5.8e-15 Height; CRC cis rs4665809 0.887 rs6546716 chr2:26263836 A/G cg27170947 chr2:26402098 FAM59B -0.44 -5.8 -0.3 1.54e-8 Gut microbiome composition (summer); CRC cis rs9733 0.526 rs11204698 chr1:150659545 G/A cg17724175 chr1:150552817 MCL1 0.59 9.61 0.47 2.03e-19 Tonsillectomy; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg00492233 chr7:135242493 NUP205 0.49 6.15 0.32 2.24e-9 Thyroid stimulating hormone; CRC cis rs11608355 0.515 rs2287184 chr12:109970251 T/C cg05360138 chr12:110035743 NA 0.76 8.66 0.43 2.15e-16 Neuroticism; CRC cis rs9902453 0.791 rs2729451 chr17:28131334 T/C cg26525008 chr17:28256777 EFCAB5;SSH2 -0.59 -8.86 -0.44 5.01e-17 Coffee consumption (cups per day); CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg03442064 chr6:41515050 FOXP4 -0.52 -6.2 -0.32 1.7e-9 Diisocyanate-induced asthma; CRC trans rs2567519 0.710 rs2714012 chr17:70783757 C/T cg19856771 chr13:42780042 DGKH -0.39 -5.97 -0.31 6.17e-9 Smoking initiation; CRC cis rs10504229 0.683 rs2318144 chr8:58114743 G/A cg02290350 chr8:58132656 NA -0.6 -7.22 -0.37 3.54e-12 Developmental language disorder (linguistic errors); CRC trans rs4689592 0.554 rs3951346 chr4:7073321 C/T cg07817883 chr1:32538562 TMEM39B -0.59 -7.64 -0.39 2.37e-13 Monocyte percentage of white cells; CRC trans rs66573146 0.831 rs67702333 chr4:6983040 C/G cg07817883 chr1:32538562 TMEM39B 1.33 12.86 0.58 6.21e-31 Granulocyte percentage of myeloid white cells; CRC cis rs7613875 0.620 rs3774734 chr3:50108792 C/A cg24308560 chr3:49941425 MST1R 0.43 6.59 0.34 1.78e-10 Body mass index; CRC cis rs7333181 1.000 rs12866444 chr13:112239743 C/T cg27543320 chr13:112200689 NA 0.49 6.22 0.32 1.51e-9 Menopause (age at onset); CRC cis rs6662572 0.774 rs6696284 chr1:46571684 C/A cg03123370 chr1:45965343 CCDC163P;MMACHC 0.47 6.27 0.33 1.13e-9 Blood protein levels; CRC cis rs1355223 0.583 rs2956074 chr11:34864880 T/C cg11058730 chr11:34937778 PDHX;APIP 0.71 11.49 0.54 6.29e-26 Systemic lupus erythematosus and Systemic sclerosis; CRC cis rs728616 0.867 rs7080405 chr10:81901943 G/C cg11900509 chr10:81946545 ANXA11 -0.68 -6.96 -0.36 1.91e-11 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs10504229 0.512 rs117968470 chr8:58014651 C/G cg24829409 chr8:58192753 C8orf71 -0.54 -6.59 -0.34 1.75e-10 Developmental language disorder (linguistic errors); CRC cis rs2797160 0.967 rs1777224 chr6:126019527 T/C cg05901451 chr6:126070800 HEY2 0.43 6.54 0.34 2.36e-10 Endometrial cancer; CRC trans rs9914544 0.545 rs57035178 chr17:18797767 C/T cg21372672 chr17:16614065 CCDC144A -0.39 -6.12 -0.32 2.7e-9 Educational attainment (years of education); CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg07740911 chr16:8768488 ABAT 0.44 6.27 0.33 1.13e-9 Anxiety disorder; CRC cis rs13256369 1.000 rs4841016 chr8:8572561 C/T cg00074818 chr8:8560427 CLDN23 0.42 7.66 0.39 2.09e-13 Obesity-related traits; CRC cis rs6867032 0.527 rs13153217 chr5:2012788 G/T cg26168224 chr5:2018326 NA -0.74 -12.13 -0.56 3.05e-28 Gut microbiome composition (winter); CRC cis rs2535633 0.631 rs2465101 chr3:52991307 A/T cg05573699 chr3:52720067 GNL3;PBRM1 0.4 5.79 0.3 1.66e-8 Body mass index; CRC cis rs533581 0.866 rs561795 chr16:88970818 A/G cg05579598 chr16:88989069 CBFA2T3 0.36 7.29 0.37 2.39e-12 Social autistic-like traits; CRC cis rs6952808 0.792 rs12531315 chr7:1953650 C/G cg22963979 chr7:1858916 MAD1L1 -0.53 -7.84 -0.4 6.38e-14 Bipolar disorder and schizophrenia; CRC cis rs916888 0.773 rs199445 chr17:44817408 C/T cg01570182 chr17:44337453 NA 1.22 14.45 0.62 5.36e-37 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs736408 0.634 rs11717836 chr3:52807736 A/G cg18099408 chr3:52552593 STAB1 -0.46 -7.34 -0.38 1.65e-12 Bipolar disorder; CRC trans rs1901167 1.000 rs1901167 chr5:40961164 A/G cg07701837 chr2:210516795 MAP2 0.37 5.98 0.31 5.85e-9 Cerebrospinal fluid biomarker levels; CRC cis rs7843479 1.000 rs2054711 chr8:21818060 A/G cg17168535 chr8:21777572 XPO7 0.54 8.87 0.44 4.65e-17 Mean corpuscular volume; CRC trans rs2303319 0.504 rs62189042 chr2:162602320 G/T cg14875682 chr5:52083620 ITGA1;PELO -0.73 -6.16 -0.32 2.11e-9 Cognitive function; CRC cis rs7811142 1.000 rs6962151 chr7:100028484 T/C cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.91 12.61 0.57 5.01e-30 Platelet count; CRC cis rs10751667 0.714 rs7395879 chr11:963855 G/C ch.11.42038R chr11:967971 AP2A2 0.58 9.98 0.48 1.16e-20 Alzheimer's disease (late onset); CRC cis rs2224391 0.911 rs9504368 chr6:5261460 A/C cg09085698 chr6:5261316 LYRM4;FARS2 -0.44 -5.71 -0.3 2.51e-8 Height; CRC cis rs6963495 0.818 rs73190155 chr7:105153535 T/A cg13798780 chr7:105162888 PUS7 0.68 8.08 0.41 1.27e-14 Bipolar disorder (body mass index interaction); CRC cis rs12497850 0.931 rs9311433 chr3:48863835 T/C cg20833759 chr3:49053208 WDR6;DALRD3 0.53 9.22 0.45 3.73e-18 Parkinson's disease; CRC cis rs4713118 0.629 rs172165 chr6:28020814 T/G cg25164649 chr6:28176230 NA 0.64 8.67 0.43 1.95e-16 Parkinson's disease; CRC trans rs1814175 0.645 rs1874969 chr11:49826700 G/A cg03929089 chr4:120376271 NA -0.89 -15.26 -0.64 3.82e-40 Height; CRC cis rs870825 0.616 rs6810635 chr4:185616859 T/C cg04058563 chr4:185651563 MLF1IP 0.72 9.31 0.46 1.84e-18 Blood protein levels; CRC cis rs6951245 1.000 rs80031817 chr7:1096793 T/C cg26224354 chr7:1096374 C7orf50;GPR146 -0.93 -12.11 -0.56 3.59e-28 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC trans rs10435719 0.902 rs6601633 chr8:11805173 C/T cg06636001 chr8:8085503 FLJ10661 -0.49 -7.39 -0.38 1.24e-12 C-reactive protein levels or triglyceride levels (pleiotropy); CRC cis rs9649213 0.593 rs7807455 chr7:97957622 C/A cg21770322 chr7:97807741 LMTK2 0.53 8.59 0.43 3.62e-16 Prostate cancer (SNP x SNP interaction); CRC cis rs2635047 0.811 rs12958943 chr18:44786818 T/C cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.36 5.62 0.3 4.08e-8 Educational attainment; CRC cis rs992157 0.687 rs10206984 chr2:219066980 C/T cg04731861 chr2:219085781 ARPC2 -0.31 -6.74 -0.35 7.21e-11 Colorectal cancer; CRC cis rs6504622 0.905 rs197926 chr17:45012087 A/G cg16759221 chr17:45003025 GOSR2 -0.53 -8.59 -0.43 3.58e-16 Orofacial clefts; CRC cis rs651907 0.557 rs34457525 chr3:101435225 C/T cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.59 7.98 0.4 2.45e-14 Colorectal cancer; CRC cis rs7586879 0.681 rs6756609 chr2:25121125 C/A cg22495460 chr2:25135724 ADCY3 -0.87 -16.98 -0.68 6.95e-47 Body mass index; CRC cis rs6088590 0.561 rs2295444 chr20:33173883 C/T cg24642439 chr20:33292090 TP53INP2 0.4 6.87 0.35 3.32e-11 Coronary artery disease; CRC cis rs6502050 0.799 rs34795957 chr17:80118013 G/A cg13198984 chr17:80129470 CCDC57 0.46 8.24 0.41 4.11e-15 Life satisfaction; CRC cis rs910316 1.000 rs3742780 chr14:75505008 G/C cg08847533 chr14:75593920 NEK9 0.95 18.1 0.71 2.76e-51 Height; CRC cis rs7258465 1.000 rs271624 chr19:18627953 A/G cg06462663 chr19:18546047 ISYNA1 0.51 7.73 0.39 1.32e-13 Breast cancer; CRC cis rs7246657 0.943 rs1559229 chr19:37876197 T/C cg23950597 chr19:37808831 NA -0.47 -5.76 -0.3 1.95e-8 Coronary artery calcification; CRC cis rs875971 0.825 rs66981195 chr7:66079035 C/A cg18252515 chr7:66147081 NA 0.43 6.12 0.32 2.62e-9 Aortic root size; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg04914231 chr16:30006637 INO80E;HIRIP3 0.39 6.24 0.33 1.34e-9 Liver disease severity in Alagille syndrome; CRC cis rs896854 1.000 rs896854 chr8:95960511 T/C cg13393036 chr8:95962371 TP53INP1 -0.53 -8.91 -0.44 3.61e-17 Type 2 diabetes; CRC cis rs2404602 0.662 rs908817 chr15:76639191 G/A cg23625390 chr15:77176239 SCAPER -0.83 -13.08 -0.58 9.46e-32 Blood metabolite levels; CRC cis rs9894429 0.809 rs9889642 chr17:79591762 T/C cg18240062 chr17:79603768 NPLOC4 0.56 9.32 0.46 1.76e-18 Eye color traits; CRC cis rs501120 0.657 rs1704222 chr10:44710465 T/A cg09554077 chr10:44749378 NA 0.65 7.29 0.37 2.37e-12 Coronary artery disease;Coronary heart disease; CRC cis rs801193 1.000 rs2659909 chr7:66160279 G/A cg05627663 chr7:65219948 SNORA22;CCT6P1 0.39 5.74 0.3 2.2e-8 Aortic root size; CRC cis rs7762018 0.943 rs7772889 chr6:170142458 T/C cg19338460 chr6:170058176 WDR27 -0.69 -7.6 -0.39 3.03e-13 Thiazide-induced adverse metabolic effects in hypertensive patients; CRC cis rs11971779 0.680 rs10229249 chr7:139052510 A/T cg23387468 chr7:139079360 LUC7L2 0.41 7.04 0.36 1.14e-11 Diisocyanate-induced asthma; CRC cis rs12926788 0.689 rs34365165 chr16:24856208 G/A cg00339695 chr16:24857497 SLC5A11 0.34 6.42 0.33 4.8e-10 Ejection fraction in Tripanosoma cruzi seropositivity; CRC cis rs1799949 0.930 rs2298861 chr17:41176831 G/A cg05368731 chr17:41323189 NBR1 0.69 10.12 0.49 3.81e-21 Menopause (age at onset); CRC cis rs35883536 0.875 rs1970227 chr1:101140723 G/A cg14515779 chr1:101123966 NA 0.36 6.61 0.34 1.57e-10 Monocyte count; CRC cis rs2228479 0.717 rs12917681 chr16:89810941 C/A cg06558623 chr16:89946397 TCF25 0.85 8.82 0.44 6.92e-17 Skin colour saturation; CRC cis rs8180040 1.000 rs295449 chr3:47375955 G/A cg10298567 chr3:47292165 KIF9 -0.39 -6.59 -0.34 1.74e-10 Colorectal cancer; CRC cis rs2243480 1.000 rs4548056 chr7:65298873 A/G cg18252515 chr7:66147081 NA -1.16 -13.54 -0.6 1.73e-33 Diabetic kidney disease; CRC cis rs1863824 0.595 rs61859067 chr10:88159997 G/A cg07322936 chr10:88137208 NA -0.63 -8.64 -0.43 2.45e-16 Schizophrenia; CRC cis rs7917772 0.503 rs10748825 chr10:104293609 A/G cg11453585 chr10:104263688 ACTR1A;SUFU 0.91 17.49 0.69 6.57e-49 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC cis rs2032447 0.966 rs9358901 chr6:26024436 G/T cg12310025 chr6:25882481 NA -0.44 -6.23 -0.32 1.46e-9 Intelligence (multi-trait analysis); CRC cis rs79839061 0.610 rs34006051 chr4:847445 C/T cg07828340 chr4:882639 GAK 1.12 10.78 0.51 2.04e-23 Intelligence (multi-trait analysis); CRC cis rs6952808 0.595 rs3800916 chr7:2166072 C/T cg02951883 chr7:2050386 MAD1L1 -0.68 -10.61 -0.51 8e-23 Bipolar disorder and schizophrenia; CRC cis rs2797160 1.000 rs1935773 chr6:125996475 A/G cg05901451 chr6:126070800 HEY2 -0.44 -6.74 -0.35 7.18e-11 Endometrial cancer; CRC cis rs7223966 1.000 rs9747164 chr17:61864787 T/C cg23090583 chr17:61904693 PSMC5;FTSJ3 0.54 6.4 0.33 5.46e-10 Hip circumference adjusted for BMI;Body mass index; CRC cis rs2836633 0.931 rs2836635 chr21:40069850 A/G cg05519781 chr21:40033154 ERG 0.58 10.41 0.5 4.15e-22 Coronary artery disease; CRC cis rs5744897 1.000 rs5744897 chr12:133226831 C/T cg26621607 chr12:133180238 NA 0.44 6.13 0.32 2.57e-9 Urate levels in overweight individuals; CRC cis rs4660531 1.000 rs4660532 chr1:41840197 C/T cg00290994 chr1:41848739 NA 0.44 6.35 0.33 7.15e-10 Bipolar disorder; CRC cis rs1577917 1.000 rs13217384 chr6:86720000 C/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.54 -7.07 -0.36 9.19e-12 Response to antipsychotic treatment; CRC trans rs11098499 0.866 rs11098506 chr4:120284971 A/G cg25214090 chr10:38739885 LOC399744 0.6 9.45 0.46 6.59e-19 Corneal astigmatism; CRC cis rs6502050 0.835 rs6502059 chr17:80082886 T/C cg19223190 chr17:80058835 NA -0.39 -6.24 -0.33 1.31e-9 Life satisfaction; CRC cis rs2806561 0.964 rs683052 chr1:23514953 T/C cg19743168 chr1:23544995 NA 0.37 5.78 0.3 1.75e-8 Height; CRC cis rs4713118 0.739 rs2893931 chr6:27748010 G/A cg20933634 chr6:27740509 NA 0.65 9.13 0.45 7.01e-18 Parkinson's disease; CRC cis rs12142240 0.698 rs67276232 chr1:46825484 T/G cg00530320 chr1:46809349 NSUN4 0.59 8.03 0.41 1.69e-14 Menopause (age at onset); CRC cis rs9323205 0.765 rs12232228 chr14:51658072 A/G cg23942311 chr14:51606299 NA 0.57 8.73 0.43 1.33e-16 Cancer; CRC cis rs12908161 1.000 rs17600551 chr15:85319258 A/G cg17507749 chr15:85114479 UBE2QP1 0.61 8.85 0.44 5.43e-17 Schizophrenia; CRC cis rs853679 0.517 rs35512245 chr6:28079953 T/C cg15845792 chr6:28175446 NA 1.0 13.06 0.58 1.11e-31 Depression; CRC cis rs25422 0.938 rs62424176 chr6:118798602 T/C cg01339444 chr6:118972232 C6orf204 0.53 5.92 0.31 8.19e-9 Renal cell carcinoma; CRC cis rs6570726 0.846 rs371186 chr6:145886971 T/C cg13319975 chr6:146136371 FBXO30 -0.39 -5.86 -0.31 1.13e-8 Lobe attachment (rater-scored or self-reported); CRC cis rs10832963 0.847 rs4237722 chr11:18639363 T/C cg20219074 chr11:18656078 SPTY2D1 0.59 8.5 0.42 6.91e-16 Breast cancer; CRC cis rs6951245 0.938 rs112425403 chr7:1071531 A/G cg03188948 chr7:1209495 NA 0.63 6.48 0.34 3.26e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg09021643 chr7:30635214 GARS 0.43 6.08 0.32 3.29e-9 Response to antipsychotic treatment; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg04959837 chr3:145968389 PLSCR4 0.44 6.33 0.33 8.11e-10 Response to antipsychotic treatment; CRC cis rs789859 0.965 rs812583 chr3:194406505 C/G cg21106136 chr3:194405973 FAM43A -0.44 -6.51 -0.34 2.74e-10 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; CRC cis rs172166 0.561 rs149974 chr6:27985096 T/C cg12172441 chr6:28176163 NA 0.44 6.39 0.33 5.72e-10 Cardiac Troponin-T levels; CRC trans rs7819412 0.502 rs4841499 chr8:10988138 A/C cg06636001 chr8:8085503 FLJ10661 -0.46 -6.34 -0.33 7.63e-10 Triglycerides; CRC cis rs4665809 1.000 rs2891490 chr2:26325927 T/C cg25036284 chr2:26402008 FAM59B -0.46 -6.0 -0.31 5.27e-9 Gut microbiome composition (summer); CRC cis rs2949837 0.504 rs2342396 chr7:45968087 C/G cg06713098 chr7:45960367 IGFBP3 0.41 6.54 0.34 2.35e-10 Sitting height ratio; CRC cis rs60871478 0.636 rs56393680 chr7:885696 A/G cg13798912 chr7:905769 UNC84A -0.64 -6.99 -0.36 1.54e-11 Cerebrospinal P-tau181p levels; CRC cis rs3785574 0.962 rs57553639 chr17:61848499 C/T cg22520471 chr17:61851767 DDX42;CCDC47 0.45 6.29 0.33 1.02e-9 Height; CRC cis rs853679 0.550 rs1237875 chr6:28173010 A/G cg15845792 chr6:28175446 NA -1.01 -15.62 -0.65 1.58e-41 Depression; CRC cis rs17376456 0.877 rs10064520 chr5:93427358 T/C cg21475434 chr5:93447410 FAM172A 0.75 7.65 0.39 2.18e-13 Diabetic retinopathy; CRC cis rs7666738 0.830 rs34212748 chr4:99068708 G/A cg05340658 chr4:99064831 C4orf37 0.6 9.33 0.46 1.57e-18 Colonoscopy-negative controls vs population controls; CRC cis rs270601 0.739 rs3900945 chr5:131592870 T/C cg11843238 chr5:131593191 PDLIM4 0.51 9.74 0.47 7.27e-20 Acylcarnitine levels; CRC cis rs9399135 0.967 rs9389251 chr6:135325717 A/G cg22676075 chr6:135203613 NA 0.42 6.51 0.34 2.78e-10 Red blood cell count; CRC cis rs7107174 0.892 rs11601866 chr11:78011153 G/A cg02023728 chr11:77925099 USP35 0.53 7.49 0.38 6.54e-13 Testicular germ cell tumor; CRC trans rs7395662 0.500 rs10838984 chr11:48640485 C/T cg03929089 chr4:120376271 NA -0.47 -6.75 -0.35 6.54e-11 HDL cholesterol; CRC cis rs1552244 0.882 rs56224841 chr3:10044014 A/C cg10729496 chr3:10149963 C3orf24 0.49 6.34 0.33 7.69e-10 Alzheimer's disease; CRC trans rs916888 0.821 rs199507 chr17:44858855 A/G cg22433210 chr17:43662623 NA -0.82 -9.07 -0.45 1.11e-17 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs2274273 0.588 rs2297816 chr14:55833038 A/G cg10130446 chr14:55658398 DLGAP5 -0.44 -6.2 -0.32 1.73e-9 Protein biomarker; CRC cis rs11098499 0.863 rs3822192 chr4:120445720 A/C cg09307838 chr4:120376055 NA 0.7 10.55 0.5 1.34e-22 Corneal astigmatism; CRC cis rs863345 0.564 rs7515245 chr1:158494110 A/G cg12129480 chr1:158549410 OR10X1 -0.29 -5.95 -0.31 7e-9 Pneumococcal bacteremia; CRC cis rs3087591 0.960 rs2905869 chr17:29519016 C/A cg24425628 chr17:29625626 OMG;NF1 0.82 15.8 0.66 3.09e-42 Hip circumference; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg22081084 chr1:89990230 LRRC8B 0.45 6.5 0.34 2.98e-10 Response to antipsychotic treatment; CRC cis rs35995292 0.500 rs6955677 chr7:38933942 C/T cg19327137 chr7:38886074 VPS41 0.62 10.19 0.49 2.31e-21 Subjective well-being (multi-trait analysis); CRC trans rs7647973 0.626 rs1491985 chr3:49739507 G/C cg21659725 chr3:3221576 CRBN -0.66 -7.5 -0.38 5.88e-13 Menarche (age at onset); CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg02360337 chr11:65627185 MUS81;CFL1 0.56 7.13 0.37 6.37e-12 Thyroid stimulating hormone; CRC cis rs6952808 0.929 rs2280548 chr7:1976667 G/T cg22963979 chr7:1858916 MAD1L1 -0.54 -7.66 -0.39 2.11e-13 Bipolar disorder and schizophrenia; CRC trans rs2303319 0.504 rs1006428 chr2:162592559 A/C cg14875682 chr5:52083620 ITGA1;PELO -0.73 -6.16 -0.32 2.11e-9 Cognitive function; CRC cis rs6952808 0.792 rs13224989 chr7:1953766 C/G cg14004847 chr7:1930337 MAD1L1 -0.42 -5.73 -0.3 2.23e-8 Bipolar disorder and schizophrenia; CRC cis rs600231 0.542 rs11227196 chr11:65234922 G/A cg17120908 chr11:65337727 SSSCA1 -0.67 -7.46 -0.38 8.02e-13 Bone mineral density; CRC cis rs2404602 0.647 rs11072626 chr15:77090826 A/G cg23625390 chr15:77176239 SCAPER -0.83 -12.98 -0.58 2.17e-31 Blood metabolite levels; CRC cis rs699 0.583 rs2493150 chr1:230868427 C/T cg07502417 chr1:230849801 AGT 0.31 6.11 0.32 2.86e-9 Coronary artery disease; CRC cis rs231513 0.954 rs11654245 chr17:41992650 T/C cg26893861 chr17:41843967 DUSP3 0.72 6.13 0.32 2.45e-9 Cognitive function; CRC cis rs7572644 0.640 rs34181670 chr2:28019856 T/C cg27432699 chr2:27873401 GPN1 0.45 5.62 0.3 4.03e-8 Response to carboplatin and paclitaxel in ovarian cancer (Caspase 3/7 EC50); CRC cis rs4819052 0.851 rs2838845 chr21:46670812 A/G cg11663144 chr21:46675770 NA -0.83 -14.85 -0.63 1.59e-38 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg21058506 chr12:66524791 LLPH 0.57 8.29 0.42 2.87e-15 Response to antipsychotic treatment; CRC cis rs10426930 0.621 rs72990138 chr19:5018217 T/A cg18473234 chr19:5097819 KDM4B 0.59 6.31 0.33 9.18e-10 Monocyte percentage of white cells; CRC trans rs16846053 0.792 rs62188983 chr2:162513959 G/C cg12500891 chr11:57225987 NA -0.67 -6.12 -0.32 2.62e-9 Blood osmolality (transformed sodium); CRC cis rs208520 0.874 rs208481 chr6:66922636 A/G cg07460842 chr6:66804631 NA -0.94 -12.2 -0.56 1.65e-28 Exhaled nitric oxide output; CRC trans rs57221529 1.000 rs57221529 chr5:586624 A/G cg11887960 chr12:57824829 NA 0.55 6.1 0.32 3.02e-9 Lung disease severity in cystic fibrosis; CRC cis rs7923609 0.967 rs3999089 chr10:65203808 C/T cg08743896 chr10:65200160 JMJD1C 0.43 6.14 0.32 2.41e-9 Educational attainment;Liver enzyme levels (alkaline phosphatase); CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg14029663 chr14:50582909 C14orf138 -0.46 -6.78 -0.35 5.72e-11 Myopia (pathological); CRC cis rs9372498 0.505 rs62422250 chr6:118990182 T/C cg07617317 chr6:118971624 C6orf204 0.53 6.14 0.32 2.33e-9 Diastolic blood pressure; CRC cis rs72634501 0.540 rs16826036 chr1:39757799 G/C cg18385671 chr1:39797026 MACF1 -0.42 -5.98 -0.31 5.94e-9 HDL cholesterol; CRC cis rs877282 1.000 rs11253361 chr10:770387 T/C cg17470449 chr10:769945 NA 0.55 7.78 0.39 9.51e-14 Uric acid levels; CRC cis rs7772486 0.817 rs2748491 chr6:146327759 T/C cg23711669 chr6:146136114 FBXO30 0.62 10.4 0.5 4.48e-22 Lobe attachment (rater-scored or self-reported); CRC cis rs9914988 0.887 rs2070265 chr17:27075423 A/G cg20469991 chr17:27169893 C17orf63 0.57 7.11 0.36 7.42e-12 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs10503871 0.657 rs13248936 chr8:30316162 C/T cg26383811 chr8:30366931 RBPMS -0.48 -7.72 -0.39 1.41e-13 Metabolite levels (X-11787); CRC cis rs9372253 1.000 rs9372253 chr6:110716136 C/T cg01119278 chr6:110721349 DDO -0.37 -6.06 -0.32 3.63e-9 Platelet distribution width; CRC cis rs3741404 0.825 rs7111753 chr11:63942189 A/G cg18225595 chr11:63971243 STIP1 0.67 11.06 0.52 2.13e-24 Platelet count; CRC cis rs12612619 0.732 rs11679681 chr2:27298479 C/A cg00617064 chr2:27272375 NA -0.38 -6.46 -0.34 3.85e-10 Venous thromboembolism adjusted for sickle cell variant rs77121243-T; CRC cis rs8067545 1.000 rs4925066 chr17:19915292 A/G cg13482628 chr17:19912719 NA 0.55 8.76 0.43 1.05e-16 Schizophrenia; CRC cis rs2243480 1.000 rs6460261 chr7:65215580 T/C cg12463550 chr7:65579703 CRCP -0.67 -6.13 -0.32 2.58e-9 Diabetic kidney disease; CRC cis rs4648845 0.579 rs4592207 chr1:2369498 A/G cg02850689 chr1:2391347 NA -0.35 -5.73 -0.3 2.27e-8 Schizophrenia; CRC cis rs6942756 0.531 rs2896415 chr7:128904523 G/A cg02491457 chr7:128862824 NA 0.53 7.73 0.39 1.36e-13 White matter hyperintensity burden; CRC cis rs7666738 0.830 rs4699574 chr4:98725544 C/T cg17366294 chr4:99064904 C4orf37 0.42 6.91 0.36 2.59e-11 Colonoscopy-negative controls vs population controls; CRC cis rs1129187 0.720 rs9471972 chr6:42915021 G/A cg05552183 chr6:42928497 GNMT 0.48 7.15 0.37 5.57e-12 Alzheimer's disease in APOE e4+ carriers; CRC cis rs1018836 0.632 rs2879361 chr8:91481909 C/T cg16814680 chr8:91681699 NA 0.59 9.69 0.47 1.11e-19 Ejection fraction in Tripanosoma cruzi seropositivity; CRC cis rs12476592 0.602 rs1446564 chr2:63731682 A/G cg10828910 chr2:63850056 LOC388955 0.49 6.08 0.32 3.33e-9 Childhood ear infection; CRC cis rs1008375 0.966 rs6839660 chr4:17667987 C/T cg04450456 chr4:17643702 FAM184B 0.39 6.12 0.32 2.59e-9 Parasitemia in Tripanosoma cruzi seropositivity; CRC trans rs916888 0.687 rs199456 chr17:44797919 C/T cg01341218 chr17:43662625 NA 0.97 10.42 0.5 3.8e-22 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs8062405 0.929 rs11864750 chr16:28875204 A/T cg16576597 chr16:28551801 NUPR1 0.48 6.82 0.35 4.39e-11 Cognitive ability (multi-trait analysis);Cognitive ability; CRC cis rs4308124 0.708 rs6749633 chr2:111988016 A/G cg04571233 chr2:111982156 NA 0.55 8.29 0.42 2.97e-15 Vitiligo; CRC trans rs1814175 0.645 rs1851869 chr11:49960552 T/C cg11707556 chr5:10655725 ANKRD33B -0.52 -10.05 -0.48 6.61e-21 Height; CRC cis rs11190604 1.000 rs3793706 chr10:102269085 A/C cg16342193 chr10:102329863 NA 0.34 5.75 0.3 2.04e-8 Palmitoleic acid (16:1n-7) levels; CRC cis rs2153535 0.580 rs1119691 chr6:8460452 C/T cg21535247 chr6:8435926 SLC35B3 0.5 7.55 0.38 4.28e-13 Motion sickness; CRC trans rs2228479 0.717 rs2270460 chr16:89972416 C/A cg21302420 chr1:112162376 RAP1A 0.65 6.53 0.34 2.45e-10 Skin colour saturation; CRC trans rs7824557 0.505 rs2736313 chr8:11086942 C/T cg08071915 chr8:12219732 FAM66A -0.37 -6.64 -0.34 1.32e-10 Retinal vascular caliber; CRC cis rs1046896 0.553 rs8073413 chr17:80836005 G/A cg19500275 chr17:80737654 TBCD 0.53 7.2 0.37 4.19e-12 Glycated hemoglobin levels; CRC cis rs6951245 1.000 rs74369356 chr7:1071711 T/C cg18402987 chr7:1209562 NA 0.64 6.77 0.35 6.03e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs9381040 0.655 rs9381032 chr6:41044986 A/T cg03644281 chr6:41068752 NFYA;LOC221442 -0.46 -6.53 -0.34 2.48e-10 Alzheimer's disease (late onset); CRC cis rs9322193 0.923 rs9322196 chr6:149940781 T/G cg05861140 chr6:150128134 PCMT1 -0.36 -5.85 -0.31 1.17e-8 Lung cancer; CRC cis rs10883723 0.810 rs17782574 chr10:104279394 G/A cg22532475 chr10:104410764 TRIM8 -0.36 -6.62 -0.34 1.45e-10 Allergic disease (asthma, hay fever or eczema); CRC cis rs10504229 0.683 rs2318147 chr8:58114931 C/T cg11062466 chr8:58055876 NA 0.49 6.09 0.32 3.11e-9 Developmental language disorder (linguistic errors); CRC cis rs6951245 1.000 rs78308415 chr7:1072634 G/A cg07217954 chr7:1067459 C7orf50 0.56 5.69 0.3 2.77e-8 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs1448094 0.556 rs11610789 chr12:86169541 A/G cg19622623 chr12:86230825 RASSF9 -0.37 -5.63 -0.3 3.81e-8 Major depressive disorder; CRC cis rs787274 0.850 rs10739378 chr9:115639631 C/T cg13803584 chr9:115635662 SNX30 -0.63 -5.88 -0.31 1.03e-8 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs9287719 0.649 rs10190774 chr2:10718746 T/A cg00105475 chr2:10696890 NA 0.45 7.06 0.36 9.97e-12 Prostate cancer; CRC trans rs9329221 0.662 rs13254942 chr8:10257678 C/T cg06636001 chr8:8085503 FLJ10661 -0.54 -8.42 -0.42 1.22e-15 Neuroticism; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg14806103 chr8:121457329 MTBP;MRPL13 0.4 6.12 0.32 2.67e-9 Liver disease severity in Alagille syndrome; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg19212674 chr4:71571625 RUFY3 0.46 6.05 0.32 4.03e-9 Thyroid stimulating hormone; CRC cis rs3857067 0.967 rs1509942 chr4:95013440 G/T cg11021082 chr4:95130006 SMARCAD1 -0.4 -6.05 -0.32 3.9e-9 QT interval; CRC cis rs7769051 0.711 rs9493437 chr6:133088405 A/T cg07930552 chr6:133119739 C6orf192 0.57 6.78 0.35 5.67e-11 Type 2 diabetes nephropathy; CRC cis rs6570726 0.905 rs442435 chr6:145815559 C/T cg05347473 chr6:146136440 FBXO30 0.37 5.91 0.31 8.46e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs4713118 0.516 rs6931858 chr6:28078411 A/T cg06470822 chr6:28175283 NA 0.92 11.69 0.54 1.26e-26 Parkinson's disease; CRC cis rs6951245 1.000 rs11767527 chr7:1097394 T/C cg20603222 chr7:1096387 C7orf50;GPR146 -0.72 -8.66 -0.43 2.19e-16 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs57221529 0.766 rs1399381 chr5:589853 G/T cg14541582 chr5:601475 NA -0.37 -7.17 -0.37 5.13e-12 Lung disease severity in cystic fibrosis; CRC cis rs734999 0.545 rs6666430 chr1:2698950 G/A cg20673091 chr1:2541236 MMEL1 0.37 5.83 0.31 1.33e-8 Ulcerative colitis; CRC cis rs4713118 0.513 rs149954 chr6:28035246 G/A cg06470822 chr6:28175283 NA 0.8 12.0 0.55 9.29e-28 Parkinson's disease; CRC cis rs17376456 0.825 rs10051878 chr5:93064164 T/G cg25358565 chr5:93447407 FAM172A 1.02 10.15 0.49 3.07e-21 Diabetic retinopathy; CRC cis rs7246967 0.736 rs398945 chr19:22997116 A/T cg23217946 chr19:22817039 ZNF492 -0.4 -5.74 -0.3 2.18e-8 Bronchopulmonary dysplasia; CRC cis rs1863824 0.625 rs12354988 chr10:88155204 G/A cg07322936 chr10:88137208 NA -0.63 -8.76 -0.44 1.03e-16 Schizophrenia; CRC cis rs9914988 0.619 rs34580233 chr17:27317935 A/T cg16670446 chr17:27188758 MIR451;MIR144 0.48 6.63 0.34 1.35e-10 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs9435341 0.965 rs1730862 chr1:107614003 G/A cg15468180 chr1:107600409 PRMT6 -0.42 -6.36 -0.33 6.79e-10 Facial morphology (factor 21, depth of nasal alae); CRC cis rs11764590 0.715 rs62444907 chr7:2083267 C/T cg25834613 chr7:1915315 MAD1L1 -0.45 -6.36 -0.33 6.83e-10 Neuroticism; CRC trans rs2294025 0.899 rs7836457 chr8:134164920 T/C cg19857114 chr3:176741225 TBL1XR1 -0.39 -6.13 -0.32 2.51e-9 Graves' disease; CRC cis rs6502050 0.871 rs9916649 chr17:80075739 G/A cg19223190 chr17:80058835 NA -0.41 -6.56 -0.34 2.07e-10 Life satisfaction; CRC cis rs4481887 0.893 rs28579823 chr1:248506881 C/T cg00666640 chr1:248458726 OR2T12 0.49 9.13 0.45 6.88e-18 Common traits (Other); CRC cis rs17270561 0.609 rs4712970 chr6:25770707 G/A cg17691542 chr6:26056736 HIST1H1C 0.65 8.29 0.42 2.94e-15 Iron status biomarkers; CRC cis rs6570726 0.791 rs4332001 chr6:145934841 T/C cg13319975 chr6:146136371 FBXO30 -0.44 -6.53 -0.34 2.44e-10 Lobe attachment (rater-scored or self-reported); CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg06762403 chr12:56325867 DGKA 0.44 6.03 0.32 4.51e-9 Anxiety disorder; CRC cis rs4819052 0.851 rs7281263 chr21:46695606 T/C cg19498844 chr21:46707878 POFUT2;LOC642852 0.79 11.53 0.54 4.72e-26 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs10779751 1.000 rs7526649 chr1:11278163 C/T cg08854313 chr1:11322531 MTOR 0.68 9.7 0.47 9.65e-20 Body mass index; CRC cis rs4727963 0.792 rs1525469 chr7:122718038 A/G cg03640110 chr7:122635026 TAS2R16 0.35 6.29 0.33 1.04e-9 Adverse response to chemotherapy (neutropenia/leucopenia) (docetaxel); CRC cis rs524281 1.000 rs565198 chr11:65913508 A/T cg16950941 chr11:66035639 RAB1B 0.62 8.65 0.43 2.31e-16 Electroencephalogram traits; CRC cis rs7618915 0.547 rs3774365 chr3:52642487 T/C cg18404041 chr3:52824283 ITIH1 -0.42 -8.6 -0.43 3.38e-16 Bipolar disorder; CRC cis rs6860806 0.507 rs273915 chr5:131660119 G/C cg09877947 chr5:131593287 PDLIM4 0.44 7.14 0.37 5.98e-12 Breast cancer; CRC cis rs7131987 0.903 rs1991114 chr12:29392082 G/T cg09582351 chr12:29534625 ERGIC2 -0.32 -6.82 -0.35 4.28e-11 QT interval; CRC trans rs4785204 1.000 rs4785203 chr16:50096065 C/T cg07960154 chr17:37760198 NEUROD2 -0.64 -6.03 -0.32 4.47e-9 Esophageal cancer (squamous cell); CRC cis rs7618915 0.547 rs4130905 chr3:52709831 A/T cg10802521 chr3:52805072 NEK4 -0.58 -8.85 -0.44 5.34e-17 Bipolar disorder; CRC cis rs9323205 0.723 rs61987304 chr14:51741213 A/G cg23942311 chr14:51606299 NA -0.51 -5.74 -0.3 2.2e-8 Cancer; CRC cis rs172166 0.694 rs1150666 chr6:28123928 T/C cg03623178 chr6:28175578 NA 0.8 11.78 0.54 5.62e-27 Cardiac Troponin-T levels; CRC cis rs4253772 0.678 rs1053332 chr22:46640179 A/G cg09491104 chr22:46646882 C22orf40 -0.45 -7.15 -0.37 5.8e-12 LDL cholesterol;Cholesterol, total; CRC trans rs7324845 0.624 rs7328262 chr13:46708731 C/A cg15277906 chr8:97170364 GDF6 0.59 6.0 0.31 5.3e-9 Non-alcoholic fatty liver disease histology (other); CRC cis rs2180341 1.000 rs9375499 chr6:127618072 T/C cg24812749 chr6:127587940 RNF146 0.94 13.67 0.6 5.36e-34 Breast cancer; CRC cis rs2836974 0.602 rs2037925 chr21:40699931 C/T cg11644478 chr21:40555479 PSMG1 -0.64 -10.15 -0.49 3.19e-21 Cognitive function; CRC cis rs9649213 0.593 rs35535338 chr7:97962319 C/T cg21770322 chr7:97807741 LMTK2 0.52 8.54 0.43 5.11e-16 Prostate cancer (SNP x SNP interaction); CRC cis rs4481887 0.504 rs11204610 chr1:248363324 C/T cg00666640 chr1:248458726 OR2T12 0.44 7.07 0.36 9.39e-12 Common traits (Other); CRC trans rs6956675 0.915 rs4285375 chr7:62650353 C/T cg01314568 chr7:57830625 NA -0.63 -8.94 -0.44 2.87e-17 Obesity-related traits; CRC cis rs11191205 0.686 rs10786640 chr10:103392633 A/T cg15320455 chr10:103880129 LDB1 0.55 6.13 0.32 2.52e-9 Intelligence (multi-trait analysis); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg00347280 chr1:45477834 HECTD3;UROD 0.44 6.32 0.33 8.61e-10 Intelligence (multi-trait analysis); CRC cis rs478304 0.934 rs474483 chr11:65520060 T/G cg27068330 chr11:65405492 SIPA1 0.48 7.0 0.36 1.45e-11 Acne (severe); CRC cis rs2742417 1.000 rs1609554 chr3:45735192 A/G cg04837898 chr3:45731254 SACM1L -0.34 -5.63 -0.3 3.95e-8 Response to anti-depressant treatment in major depressive disorder; CRC cis rs17021463 0.643 rs17311521 chr4:95298060 A/G cg11021082 chr4:95130006 SMARCAD1 -0.42 -6.06 -0.32 3.78e-9 Testicular germ cell tumor; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg11611950 chr6:24667276 ACOT13;TTRAP 0.39 6.09 0.32 3.12e-9 Intelligence (multi-trait analysis); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg19761014 chr17:28927070 LRRC37B2 0.42 6.29 0.33 1.02e-9 Response to antipsychotic treatment; CRC cis rs992157 0.767 rs2382822 chr2:219173327 T/C cg04880052 chr2:219191631 PNKD -0.45 -7.04 -0.36 1.15e-11 Colorectal cancer; CRC cis rs6502050 0.529 rs35585236 chr17:80116641 T/C cg02741985 chr17:80059408 CCDC57 0.43 7.18 0.37 4.68e-12 Life satisfaction; CRC cis rs3733585 0.664 rs17185870 chr4:9958214 C/A cg11266682 chr4:10021025 SLC2A9 -0.47 -9.64 -0.47 1.58e-19 Cleft plate (environmental tobacco smoke interaction); CRC cis rs4478858 0.684 rs12135540 chr1:31764693 G/A cg00250761 chr1:31883323 NA -0.4 -7.65 -0.39 2.23e-13 Alcohol dependence; CRC cis rs7827545 1.000 rs4909909 chr8:135564627 T/C cg13086574 chr8:135490821 ZFAT -0.36 -6.08 -0.32 3.34e-9 Hypertension (SNP x SNP interaction); CRC cis rs380904 0.552 rs10099003 chr8:144645460 C/T cg20583945 chr8:144636462 GSDMD 0.47 5.82 0.31 1.43e-8 Venous thromboembolism (SNP x SNP interaction); CRC cis rs6088580 0.524 rs6088567 chr20:33263872 A/T cg08999081 chr20:33150536 PIGU -0.38 -5.69 -0.3 2.79e-8 Glomerular filtration rate (creatinine); CRC cis rs2762353 0.779 rs1408273 chr6:25840946 C/T cg03264133 chr6:25882463 NA 0.43 6.47 0.34 3.47e-10 Blood metabolite levels; CRC cis rs12580194 0.593 rs7311751 chr12:55748847 A/G cg19537932 chr12:55886519 OR6C68 -0.69 -8.94 -0.44 2.82e-17 Cancer; CRC trans rs9354308 0.933 rs2802064 chr6:66564352 C/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.47 5.99 0.31 5.47e-9 Metabolite levels; CRC cis rs4561483 0.801 rs33623 chr16:12007435 A/G cg08843971 chr16:11963173 GSPT1 0.63 9.8 0.48 4.73e-20 Testicular germ cell tumor; CRC cis rs17767392 0.958 rs12892512 chr14:71983296 G/A cg13720639 chr14:72061746 SIPA1L1 -0.57 -7.26 -0.37 2.77e-12 Mitral valve prolapse; CRC cis rs2836974 0.897 rs1541102 chr21:40628765 C/T cg11644478 chr21:40555479 PSMG1 0.82 13.11 0.59 7.16e-32 Cognitive function; CRC cis rs1670533 1.000 rs7660779 chr4:1075940 A/G cg27284194 chr4:1044797 NA 0.5 6.3 0.33 9.65e-10 Recombination rate (females); CRC cis rs2108622 0.727 rs7256877 chr19:15980683 T/C cg13772218 chr19:15982569 NA 0.48 6.81 0.35 4.67e-11 Circulating phylloquinone levels;Vitamin E levels;Acenocoumarol maintenance dosage;Response to Vitamin E supplementation;Metabolite levels;Warfarin maintenance dose; CRC cis rs10504229 0.683 rs16921808 chr8:58106049 C/T cg02725872 chr8:58115012 NA -0.66 -10.93 -0.52 6.16e-24 Developmental language disorder (linguistic errors); CRC cis rs11190604 1.000 rs2495758 chr10:102321900 C/G cg16342193 chr10:102329863 NA -0.4 -6.48 -0.34 3.33e-10 Palmitoleic acid (16:1n-7) levels; CRC cis rs995000 0.965 rs10889333 chr1:62957030 G/A cg19896129 chr1:63156450 NA 0.4 5.88 0.31 1.01e-8 Triglyceride levels; CRC cis rs2836974 0.666 rs4624474 chr21:40686327 T/C cg17971929 chr21:40555470 PSMG1 -0.64 -9.27 -0.46 2.45e-18 Cognitive function; CRC cis rs12143943 0.866 rs35666383 chr1:204492784 T/C cg17419461 chr1:204415978 PIK3C2B 0.39 6.04 0.32 4.22e-9 Cognitive performance; CRC cis rs2019137 0.560 rs7578633 chr2:113978650 C/T cg09704166 chr2:114031854 PAX8;LOC440839 -0.37 -6.66 -0.34 1.15e-10 Lymphocyte counts; CRC trans rs4745216 0.643 rs1050305 chr9:75775235 A/G cg11926456 chr2:211432972 CPS1 0.56 6.09 0.32 3.14e-9 Blood protein levels; CRC cis rs1552244 0.935 rs28815328 chr3:10062227 G/A cg18598329 chr3:10140678 FANCD2;C3orf24 -0.88 -12.26 -0.56 1.05e-28 Alzheimer's disease; CRC cis rs12545109 0.800 rs1960725 chr8:57411807 C/T cg09654669 chr8:57350985 NA -0.46 -7.45 -0.38 8.25e-13 Obesity-related traits; CRC cis rs7493 1.000 rs6961773 chr7:95037718 T/G cg07404485 chr7:94953653 PON1 -0.47 -6.18 -0.32 1.86e-9 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs1552244 0.882 rs3732967 chr3:10015437 T/C cg18598329 chr3:10140678 FANCD2;C3orf24 -0.81 -10.69 -0.51 4.18e-23 Alzheimer's disease; CRC cis rs367943 1.000 rs348958 chr5:112821137 G/A cg12552261 chr5:112820674 MCC -0.49 -7.59 -0.39 3.23e-13 Type 2 diabetes; CRC cis rs60871478 1.000 rs34761279 chr7:794471 A/G cg05535760 chr7:792225 HEATR2 0.95 11.88 0.55 2.53e-27 Cerebrospinal P-tau181p levels; CRC cis rs3733585 0.673 rs6814664 chr4:9956228 C/T cg11266682 chr4:10021025 SLC2A9 -0.47 -9.69 -0.47 1.05e-19 Cleft plate (environmental tobacco smoke interaction); CRC cis rs4516970 0.826 rs59246098 chr6:160149462 C/CA cg25736982 chr6:160182554 ACAT2 0.56 8.1 0.41 1.11e-14 Iron status biomarkers; CRC trans rs2727020 0.734 rs1164664 chr11:49295542 T/G cg03929089 chr4:120376271 NA 0.62 8.2 0.41 5.52e-15 Coronary artery disease; CRC cis rs1519814 0.956 rs7016388 chr8:121101865 A/G cg22335954 chr8:121166405 COL14A1 -0.51 -6.09 -0.32 3.08e-9 Breast cancer; CRC cis rs798554 0.757 rs1182185 chr7:2872233 A/G cg04166393 chr7:2884313 GNA12 0.46 6.34 0.33 7.42e-10 Height; CRC cis rs1129187 0.818 rs9462858 chr6:42946490 C/A cg02353165 chr6:42928485 GNMT 0.84 15.09 0.64 1.82e-39 Alzheimer's disease in APOE e4+ carriers; CRC cis rs7584330 0.554 rs3751110 chr2:238427142 T/C cg08992911 chr2:238395768 MLPH 0.47 5.75 0.3 2.04e-8 Prostate cancer; CRC cis rs4844614 0.951 rs17049197 chr1:207874704 G/A cg17822947 chr1:207842917 CR1L -0.36 -5.79 -0.3 1.63e-8 LDL cholesterol; CRC cis rs868943 0.511 rs12204724 chr6:116532430 C/T cg18764771 chr6:116381957 FRK 0.23 5.63 0.3 3.89e-8 Total cholesterol levels; CRC cis rs4332037 0.754 rs62436669 chr7:1926636 G/A cg21155852 chr7:2048760 MAD1L1 -0.49 -6.69 -0.35 9.76e-11 Bipolar disorder; CRC cis rs10242455 0.702 rs74552228 chr7:98977046 C/T cg18809830 chr7:99032528 PTCD1 -1.09 -7.78 -0.39 9.4e-14 Blood metabolite levels; CRC cis rs2625529 0.526 rs11634622 chr15:72562327 G/A cg16672083 chr15:72433130 SENP8 0.45 6.88 0.35 2.95e-11 Red blood cell count; CRC cis rs10992471 0.631 rs2296667 chr9:95274338 A/G cg13798575 chr9:95087839 CENPP;NOL8 -0.41 -6.02 -0.31 4.78e-9 Visceral adipose tissue/subcutaneous adipose tissue ratio; CRC trans rs208515 0.556 rs1872309 chr6:66660432 A/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.73 9.35 0.46 1.35e-18 Exhaled nitric oxide levels; CRC trans rs2727020 0.619 rs1829979 chr11:49436875 T/G cg11707556 chr5:10655725 ANKRD33B -0.47 -7.45 -0.38 8.39e-13 Coronary artery disease; CRC cis rs1997103 0.911 rs6945663 chr7:55407011 C/G cg17469321 chr7:55412551 NA 0.72 11.28 0.53 3.48e-25 QRS interval (sulfonylurea treatment interaction); CRC trans rs61931739 0.517 rs4931748 chr12:34140827 C/T cg26384229 chr12:38710491 ALG10B 0.51 6.65 0.34 1.24e-10 Morning vs. evening chronotype; CRC cis rs1868673 1.000 rs16862651 chr3:150157388 C/T cg04908077 chr3:150187338 NA -0.33 -5.64 -0.3 3.58e-8 Waist circumference; CRC cis rs7517126 1.000 rs34673990 chr1:196838757 G/A cg13682187 chr1:196946512 CFHR5 -0.36 -5.91 -0.31 8.52e-9 Blood protein levels; CRC cis rs3018066 0.666 rs4323181 chr4:107029515 A/G cg01869342 chr4:106983673 TBCK 0.45 5.93 0.31 7.73e-9 Cancer; CRC trans rs1814175 0.817 rs7483795 chr11:49704930 G/A cg03929089 chr4:120376271 NA -0.95 -18.15 -0.71 1.64e-51 Height; CRC cis rs4700695 0.925 rs12657113 chr5:65396959 A/C cg21114390 chr5:65439923 SFRS12 -0.49 -6.35 -0.33 7.17e-10 Facial morphology (factor 19); CRC cis rs9649213 0.593 rs6948540 chr7:97960066 A/G cg00277769 chr7:97922759 BAIAP2L1 -0.61 -10.65 -0.51 5.96e-23 Prostate cancer (SNP x SNP interaction); CRC cis rs6840360 0.606 rs2724550 chr4:152358986 C/T cg09659197 chr4:152720779 NA 0.34 6.66 0.34 1.14e-10 Intelligence (multi-trait analysis); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg05671585 chr4:186064123 SLC25A4 0.41 6.6 0.34 1.65e-10 Liver disease severity in Alagille syndrome; CRC cis rs8180040 0.966 rs12636851 chr3:47463567 C/T cg27129171 chr3:47204927 SETD2 0.61 9.47 0.46 5.59e-19 Colorectal cancer; CRC cis rs1799949 0.965 rs2236762 chr17:41226675 A/T cg25072359 chr17:41440525 NA 0.52 8.3 0.42 2.69e-15 Menopause (age at onset); CRC trans rs1728785 1.000 rs12918865 chr16:68566546 G/A cg04657470 chr2:198365150 HSPE1;HSPD1 0.57 6.81 0.35 4.59e-11 Ulcerative colitis; CRC cis rs2067615 0.579 rs7486905 chr12:107160169 G/A cg13491945 chr12:107078410 RFX4 0.34 5.93 0.31 7.87e-9 Heart rate; CRC cis rs9611565 0.921 rs5751077 chr22:41720728 G/C cg03806693 chr22:41940476 POLR3H -0.63 -8.86 -0.44 5.09e-17 Vitiligo; CRC cis rs7904368 0.754 rs7076955 chr10:16852781 G/A cg23933602 chr10:16859644 RSU1 0.54 6.04 0.32 4.22e-9 Ratio of the peak velocity of the mitral E-Wave divided by the peak velocity of the mitral A-wave.; CRC cis rs929354 0.772 rs2301916 chr7:156974127 G/T cg16102536 chr7:156981717 UBE3C 0.4 6.78 0.35 5.54e-11 Body mass index; CRC cis rs7927771 1.000 rs10838748 chr11:47716381 T/G cg18512352 chr11:47633146 NA -0.49 -9.71 -0.47 9.31e-20 Subjective well-being; CRC cis rs9733 0.596 rs1415148 chr1:150705755 G/A cg17724175 chr1:150552817 MCL1 0.56 8.82 0.44 7.03e-17 Tonsillectomy; CRC cis rs28386778 0.897 rs2665797 chr17:61922485 C/G cg07362569 chr17:61921086 SMARCD2 -0.36 -5.64 -0.3 3.63e-8 Prudent dietary pattern; CRC cis rs13108904 0.557 rs1250086 chr4:1248051 G/A cg19318889 chr4:1322082 MAEA -0.65 -9.36 -0.46 1.29e-18 Obesity-related traits; CRC cis rs9911578 0.867 rs72628394 chr17:57121313 C/T cg12560992 chr17:57184187 TRIM37 -0.87 -16.13 -0.66 1.53e-43 Intelligence (multi-trait analysis); CRC cis rs427394 0.664 rs274697 chr5:6731477 A/C cg10857441 chr5:6722123 POLS -0.4 -6.12 -0.32 2.64e-9 Menopause (age at onset); CRC cis rs9372498 0.536 rs9489450 chr6:118904385 G/A cg07617317 chr6:118971624 C6orf204 0.49 6.06 0.32 3.7e-9 Diastolic blood pressure; CRC cis rs2760061 0.819 rs708111 chr1:228191365 G/A cg02753203 chr1:228287806 NA 0.68 10.44 0.5 3.19e-22 Diastolic blood pressure; CRC cis rs7647973 0.826 rs9834535 chr3:49378797 A/T cg20833759 chr3:49053208 WDR6;DALRD3 0.52 7.73 0.39 1.31e-13 Menarche (age at onset); CRC cis rs9435341 0.929 rs1730865 chr1:107605611 A/C cg14671364 chr1:107599128 PRMT6 0.61 8.29 0.42 2.92e-15 Facial morphology (factor 21, depth of nasal alae); CRC cis rs3785574 0.962 rs35448669 chr17:61938923 G/A cg06601766 chr17:61851465 DDX42;CCDC47 0.58 8.11 0.41 9.94e-15 Height; CRC cis rs9381040 0.655 rs4140578 chr6:41041829 A/G cg03644281 chr6:41068752 NFYA;LOC221442 -0.46 -6.52 -0.34 2.6200000000000003e-10 Alzheimer's disease (late onset); CRC cis rs6951245 1.000 rs11763020 chr7:1060288 C/T cg24642844 chr7:1081250 C7orf50 -0.77 -9.27 -0.46 2.46e-18 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs9381040 0.655 rs879491 chr6:41026953 A/G cg25110423 chr6:41068646 NFYA;LOC221442 -0.39 -5.93 -0.31 7.66e-9 Alzheimer's disease (late onset); CRC cis rs10193935 0.892 rs12612372 chr2:42414035 A/G cg27598129 chr2:42591480 NA -0.71 -8.3 -0.42 2.69e-15 Colonoscopy-negative controls vs population controls; CRC cis rs11628318 0.614 rs62007925 chr14:103128288 G/A cg23461800 chr14:103021989 NA 0.68 7.74 0.39 1.23e-13 Platelet count; CRC cis rs6456156 1.000 rs6911766 chr6:167523170 T/G cg07741184 chr6:167504864 NA -0.33 -5.68 -0.3 2.97e-8 Primary biliary cholangitis; CRC cis rs561341 1.000 rs15654 chr17:30326360 A/C cg19193384 chr17:30244184 NA -0.65 -7.57 -0.39 3.82e-13 Hip circumference adjusted for BMI; CRC trans rs6952808 0.692 rs11765549 chr7:2027311 G/T cg04565464 chr8:145669602 NFKBIL2 0.44 6.01 0.31 4.84e-9 Bipolar disorder and schizophrenia; CRC cis rs875971 0.862 rs4368860 chr7:65608482 C/G cg18252515 chr7:66147081 NA 0.4 5.78 0.3 1.72e-8 Aortic root size; CRC cis rs12928939 0.862 rs7197104 chr16:71794061 C/T cg08717414 chr16:71523259 ZNF19 -0.48 -5.89 -0.31 9.38e-9 Post bronchodilator FEV1; CRC cis rs11098499 0.909 rs73842633 chr4:120375464 G/A cg24375607 chr4:120327624 NA 0.51 7.86 0.4 5.59e-14 Corneal astigmatism; CRC cis rs7223966 1.000 rs7209758 chr17:61913621 C/T cg05941027 chr17:61774174 LIMD2 0.34 5.96 0.31 6.36e-9 Hip circumference adjusted for BMI;Body mass index; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg20789954 chr3:132441258 NCRNA00119;NPHP3 0.4 6.46 0.34 3.7e-10 Liver disease severity in Alagille syndrome; CRC cis rs7712401 0.791 rs1870559 chr5:122116706 G/C cg18764291 chr5:122110994 SNX2 0.42 6.8 0.35 4.89e-11 Mean platelet volume; CRC cis rs9311474 0.632 rs6445528 chr3:52572447 C/T cg18404041 chr3:52824283 ITIH1 0.34 7.0 0.36 1.47e-11 Electroencephalogram traits; CRC cis rs9443645 1.000 rs9443645 chr6:79822924 C/T cg09184832 chr6:79620586 NA -0.45 -8.17 -0.41 6.65e-15 Intelligence (multi-trait analysis); CRC cis rs17539620 0.624 rs62432737 chr6:154834772 G/A cg20019720 chr6:154832845 CNKSR3 0.5 8.21 0.41 5.03e-15 Lipoprotein (a) levels; CRC cis rs4665809 1.000 rs12475854 chr2:26267375 G/A cg22920501 chr2:26401640 FAM59B -0.49 -6.83 -0.35 4.12e-11 Gut microbiome composition (summer); CRC cis rs6540556 0.723 rs11487866 chr1:209892046 G/A cg05527609 chr1:210001259 C1orf107 -0.55 -6.03 -0.32 4.39e-9 Red blood cell count; CRC cis rs4862750 0.957 rs4861733 chr4:187903933 C/T cg03647317 chr4:187891568 NA -0.55 -9.85 -0.48 3.04e-20 Lobe attachment (rater-scored or self-reported); CRC cis rs4843747 0.605 rs4072779 chr16:88107290 C/T cg17633681 chr16:88106987 BANP 0.87 16.24 0.67 5.81e-44 Menopause (age at onset); CRC cis rs6456156 0.565 rs12529238 chr6:167465576 G/A cg07741184 chr6:167504864 NA 0.39 6.91 0.36 2.54e-11 Primary biliary cholangitis; CRC cis rs600231 0.508 rs11227202 chr11:65242717 G/A cg17120908 chr11:65337727 SSSCA1 -0.69 -7.71 -0.39 1.54e-13 Bone mineral density; CRC cis rs9611565 0.765 rs132909 chr22:41802031 G/A cg06481639 chr22:41940642 POLR3H 0.49 5.73 0.3 2.32e-8 Vitiligo; CRC cis rs8016982 0.657 rs11625861 chr14:81735001 C/T cg01989461 chr14:81687754 GTF2A1 -0.59 -9.53 -0.47 3.63e-19 Schizophrenia; CRC trans rs17685 0.725 rs6467993 chr7:75719350 G/A cg19862616 chr7:65841803 NCRNA00174 0.98 18.26 0.71 6.01e-52 Coffee consumption;Coffee consumption (cups per day); CRC cis rs763014 1.000 rs2269558 chr16:682250 C/T cg00908189 chr16:619842 PIGQ 0.64 10.3 0.49 9.79e-22 Height; CRC cis rs6952808 0.595 rs3778983 chr7:2166319 T/G cg22963979 chr7:1858916 MAD1L1 -0.46 -6.6 -0.34 1.6e-10 Bipolar disorder and schizophrenia; CRC cis rs896854 0.967 rs10956933 chr8:95967688 C/G cg16049864 chr8:95962084 TP53INP1 -0.68 -12.38 -0.56 3.73e-29 Type 2 diabetes; CRC cis rs11190604 1.000 rs2495755 chr10:102324649 A/C cg16342193 chr10:102329863 NA -0.4 -6.48 -0.34 3.33e-10 Palmitoleic acid (16:1n-7) levels; CRC trans rs587242 1.000 rs61786494 chr1:96905987 A/G cg10631902 chr5:14652156 NA 0.44 6.84 0.35 3.84e-11 Body mass index (joint analysis main effects and physical activity interaction);Body mass index in physically inactive individuals;Body mass index; CRC cis rs4975709 0.589 rs4975747 chr5:1862836 G/A cg12288994 chr5:1860383 NA 0.37 6.51 0.34 2.83e-10 Cardiovascular disease risk factors; CRC cis rs4319547 0.695 rs6488939 chr12:122858250 T/C cg23029597 chr12:123009494 RSRC2 -0.48 -6.17 -0.32 2.01e-9 Body mass index; CRC cis rs7772486 0.754 rs702306 chr6:145991029 T/C cg13319975 chr6:146136371 FBXO30 0.42 6.14 0.32 2.32e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs60871478 0.636 rs4721834 chr7:896142 C/T cg13798912 chr7:905769 UNC84A -0.63 -6.97 -0.36 1.74e-11 Cerebrospinal P-tau181p levels; CRC trans rs1864585 0.520 rs10503409 chr8:10669654 C/G cg26278703 chr11:58910052 FAM111A -0.52 -6.25 -0.33 1.28e-9 Neutrophil percentage of white cells;Lymphocyte percentage of white cells; CRC cis rs16867335 0.625 rs7573877 chr2:181478111 A/G cg23363182 chr2:181467187 NA -0.58 -9.1 -0.45 8.9e-18 Survival in rectal cancer; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg05377417 chr17:59940892 BRIP1 -0.39 -6.18 -0.32 1.86e-9 Liver disease severity in Alagille syndrome; CRC cis rs9443645 0.835 rs1044309 chr6:79646575 A/G cg11833968 chr6:79620685 NA -0.35 -6.12 -0.32 2.69e-9 Intelligence (multi-trait analysis); CRC cis rs7937682 1.000 rs10789843 chr11:111576158 C/T cg09085632 chr11:111637200 PPP2R1B 1.02 19.21 0.73 1.07e-55 Primary sclerosing cholangitis; CRC cis rs6952808 0.893 rs35487994 chr7:1920171 G/A cg21782813 chr7:2030301 MAD1L1 0.47 8.06 0.41 1.46e-14 Bipolar disorder and schizophrenia; CRC cis rs9368481 0.761 rs4358615 chr6:26998567 A/G cg05192639 chr6:26864778 GUSBL1 0.33 6.02 0.32 4.64e-9 Autism spectrum disorder or schizophrenia; CRC cis rs12142240 0.698 rs45449893 chr1:46859024 A/G cg14993813 chr1:46806288 NSUN4 -0.48 -6.03 -0.32 4.47e-9 Menopause (age at onset); CRC cis rs6912958 0.500 rs4707352 chr6:87929705 G/A cg08069147 chr6:88032118 GJB7;C6orf162 -0.74 -11.99 -0.55 9.61e-28 Monocyte percentage of white cells; CRC cis rs910316 1.000 rs12435391 chr14:75601737 A/G cg03030879 chr14:75389066 RPS6KL1 -0.49 -7.71 -0.39 1.51e-13 Height; CRC cis rs2658782 0.789 rs2658776 chr11:93147927 A/G cg15737290 chr11:93063684 CCDC67 0.49 7.07 0.36 9.29e-12 Pulmonary function decline; CRC cis rs7208859 0.573 rs11656278 chr17:29075188 C/T cg01831904 chr17:28903510 LRRC37B2 -0.62 -6.39 -0.33 5.8e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs7647973 0.580 rs7652746 chr3:49262307 C/T cg07690219 chr3:49449608 TCTA;RHOA 0.43 5.67 0.3 3.16e-8 Menarche (age at onset); CRC cis rs2066819 1.000 rs78495928 chr12:56635080 G/C cg26714650 chr12:56694279 CS -1.42 -11.61 -0.54 2.3e-26 Psoriasis vulgaris; CRC trans rs10982213 0.830 rs2274163 chr9:117188714 C/T cg10346511 chr11:30344563 C11orf46 0.38 5.97 0.31 6.11e-9 Interleukin-6 levels; CRC cis rs965469 1.000 rs6051808 chr20:3350697 A/T cg25506879 chr20:3388711 C20orf194 -0.4 -5.83 -0.31 1.35e-8 IFN-related cytopenia; CRC cis rs951366 0.789 rs823130 chr1:205714372 C/T cg11965913 chr1:205819406 PM20D1 0.83 13.17 0.59 4.18e-32 Menarche (age at onset); CRC cis rs7666738 0.830 rs58696666 chr4:99006913 C/T cg17366294 chr4:99064904 C4orf37 0.44 7.39 0.38 1.19e-12 Colonoscopy-negative controls vs population controls; CRC cis rs17376456 0.825 rs35496867 chr5:93220400 T/C cg21475434 chr5:93447410 FAM172A 0.77 7.56 0.38 4.08e-13 Diabetic retinopathy; CRC cis rs10752881 0.967 rs8179361 chr1:182974572 T/C ch.1.3577855R chr1:183094577 LAMC1 0.87 15.17 0.64 8.98e-40 Colorectal cancer; CRC cis rs2836633 1.000 rs2836633 chr21:40067445 C/T cg12884169 chr21:40033163 ERG -0.38 -8.35 -0.42 1.94e-15 Coronary artery disease; CRC cis rs1572438 0.760 rs7740748 chr6:869509 T/C cg13447295 chr6:887704 NA -0.49 -7.11 -0.36 7.39e-12 Aging; CRC cis rs1799949 0.965 rs35954893 chr17:41333786 A/G cg01879757 chr17:41196368 BRCA1 -0.44 -6.69 -0.35 9.41e-11 Menopause (age at onset); CRC trans rs970548 0.688 rs2082111 chr10:45931060 A/C cg14222797 chr10:16859974 RSU1 -0.63 -6.36 -0.33 6.72e-10 Total cholesterol levels;Cholesterol, total;HDL cholesterol;HDL cholesterol levels; CRC cis rs4909189 0.915 rs11773551 chr7:158136146 C/T cg25566285 chr7:158114605 PTPRN2 0.42 5.78 0.3 1.77e-8 Response to amphetamines; CRC cis rs2857891 1.000 rs72845397 chr11:6950903 C/T cg04053776 chr11:6947353 ZNF215 0.52 7.08 0.36 8.52e-12 Response to cytadine analogues (cytosine arabinoside); CRC cis rs7493 1.000 rs3779492 chr7:95044183 C/T cg07404485 chr7:94953653 PON1 -0.45 -5.94 -0.31 7.43e-9 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs7113874 0.544 rs9704807 chr11:8578771 G/C cg02811074 chr11:8615871 STK33 -0.34 -5.86 -0.31 1.14e-8 Body mass index in physically active individuals;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs6988985 0.728 rs10103405 chr8:143968631 T/C cg10324643 chr8:143916377 GML 0.39 6.4 0.33 5.45e-10 Plasma androstenedione levels in resected early stage-receptor positive breast cancer; CRC cis rs3796619 0.924 rs4690209 chr4:1077575 G/A cg11579758 chr4:1086637 RNF212 0.41 6.67 0.34 1.11e-10 Recombination rate (males); CRC cis rs7208859 0.623 rs122898 chr17:28905254 C/T cg13385521 chr17:29058706 SUZ12P -0.57 -6.62 -0.34 1.45e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs9361491 0.580 rs13204088 chr6:79757438 A/C cg09184832 chr6:79620586 NA -0.45 -7.74 -0.39 1.27e-13 Intelligence (multi-trait analysis); CRC cis rs9929218 1.000 rs28660361 chr16:68800838 T/C cg02972257 chr16:68554789 NA 0.44 5.61 0.3 4.28e-8 Colorectal cancer; CRC cis rs67311347 0.577 rs1317217 chr3:40271697 T/G cg09455208 chr3:40491958 NA 0.33 6.66 0.34 1.13e-10 Renal cell carcinoma; CRC cis rs13108904 0.557 rs1680033 chr4:1243404 C/T cg02018176 chr4:1364513 KIAA1530 -0.61 -9.84 -0.48 3.48e-20 Obesity-related traits; CRC cis rs780096 0.565 rs813592 chr2:27721971 T/C cg24768116 chr2:27665128 KRTCAP3 -0.33 -7.69 -0.39 1.7e-13 Total body bone mineral density; CRC cis rs1348850 0.874 rs6742951 chr2:178340766 G/C cg02961200 chr2:178257176 LOC100130691;AGPS 0.64 9.0 0.44 1.86e-17 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs12497850 0.931 rs11920534 chr3:48937761 G/T cg20833759 chr3:49053208 WDR6;DALRD3 0.48 8.18 0.41 6.42e-15 Parkinson's disease; CRC trans rs2303319 0.504 rs62189051 chr2:162622318 G/A cg12500891 chr11:57225987 NA -0.65 -6.05 -0.32 3.87e-9 Cognitive function; CRC trans rs208520 0.690 rs12208310 chr6:66730108 G/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 1.05 14.77 0.63 3.05e-38 Exhaled nitric oxide output; CRC cis rs7085104 0.700 rs10786712 chr10:104596396 A/G cg15744005 chr10:104629667 AS3MT 0.34 7.32 0.37 1.9e-12 Immature fraction of reticulocytes;Schizophrenia; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg03738959 chr9:37904295 MCART1 0.42 6.03 0.32 4.51e-9 Intelligence (multi-trait analysis); CRC cis rs897984 0.806 rs4889571 chr16:30949047 A/G cg00531865 chr16:30841666 NA 0.49 6.86 0.35 3.47e-11 Dementia with Lewy bodies; CRC trans rs208520 0.526 rs9354370 chr6:66808209 C/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 1.15 24.79 0.81 2.88e-77 Exhaled nitric oxide output; CRC cis rs3785574 0.962 rs2665835 chr17:61903258 C/T cg06873352 chr17:61820015 STRADA 0.49 7.77 0.39 1e-13 Height; CRC cis rs977987 0.742 rs34624768 chr16:75331572 G/A cg03315344 chr16:75512273 CHST6 0.54 9.05 0.45 1.24e-17 Dupuytren's disease; CRC cis rs754466 0.606 rs55854323 chr10:79589904 C/T cg26805224 chr10:79626177 DLG5 -0.5 -7.09 -0.36 8.28e-12 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs11098499 1.000 rs11098499 chr4:120187611 C/T cg24375607 chr4:120327624 NA 0.46 7.21 0.37 3.89e-12 Corneal astigmatism; CRC trans rs800082 0.516 rs1178893 chr3:144239246 A/C cg24215973 chr2:240111563 HDAC4 0.45 6.29 0.33 1.01e-9 Smoking behavior; CRC cis rs17345786 0.906 rs12638137 chr3:101150964 C/T cg12386194 chr3:101231763 SENP7 0.52 6.47 0.34 3.54e-10 Colonoscopy-negative controls vs population controls; CRC cis rs7264396 0.887 rs1570841 chr20:34048161 C/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.38 -6.07 -0.32 3.48e-9 Total cholesterol levels; CRC cis rs9462027 0.628 rs2814959 chr6:34705947 C/T cg07306190 chr6:34760872 UHRF1BP1 -0.34 -6.07 -0.32 3.49e-9 Systemic lupus erythematosus; CRC cis rs1008375 0.932 rs10009933 chr4:17670107 A/C cg16339924 chr4:17578868 LAP3 0.48 6.09 0.32 3.2e-9 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs1008375 0.931 rs2315558 chr4:17674558 C/A cg04450456 chr4:17643702 FAM184B 0.39 6.03 0.32 4.37e-9 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs6502050 0.835 rs35131307 chr17:80128439 G/A cg02741985 chr17:80059408 CCDC57 0.44 7.24 0.37 3.25e-12 Life satisfaction; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg16471585 chr12:118199103 KSR2 -0.39 -6.26 -0.33 1.19e-9 Liver disease severity in Alagille syndrome; CRC cis rs989128 0.642 rs7214956 chr17:48627148 G/C cg24438145 chr17:48624694 SPATA20 0.51 7.37 0.38 1.35e-12 Type 2 diabetes; CRC cis rs7258465 0.931 rs76195 chr19:18629830 A/G cg06462663 chr19:18546047 ISYNA1 0.5 7.64 0.39 2.45e-13 Breast cancer; CRC cis rs8013055 0.846 rs8013827 chr14:105970176 C/T cg23356831 chr14:105996513 TMEM121 -0.42 -7.23 -0.37 3.42e-12 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis); CRC cis rs2836974 0.584 rs6517535 chr21:40653352 G/C cg11644478 chr21:40555479 PSMG1 -0.7 -11.4 -0.53 1.35e-25 Cognitive function; CRC cis rs10504229 0.683 rs61241336 chr8:58106585 A/G cg05313129 chr8:58192883 C8orf71 -0.43 -5.87 -0.31 1.09e-8 Developmental language disorder (linguistic errors); CRC cis rs7089973 0.604 rs11196937 chr10:116589500 G/C cg23260525 chr10:116636907 FAM160B1 0.35 8.07 0.41 1.34e-14 Bipolar disorder or attention deficit hyperactivity disorder; CRC cis rs7737355 0.947 rs28720007 chr5:131077709 C/T cg06307176 chr5:131281290 NA 0.41 6.15 0.32 2.22e-9 Life satisfaction; CRC cis rs7208859 0.673 rs11658435 chr17:29228561 A/G cg13385521 chr17:29058706 SUZ12P 0.69 7.93 0.4 3.48e-14 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs9389248 0.737 rs56358308 chr6:135306980 A/T cg24558204 chr6:135376177 HBS1L 0.61 9.23 0.45 3.45e-18 High light scatter reticulocyte percentage of red cells; CRC cis rs7737355 1.000 rs59808242 chr5:130754894 G/A cg06307176 chr5:131281290 NA -0.39 -5.91 -0.31 8.68e-9 Life satisfaction; CRC cis rs7474896 0.526 rs1208716 chr10:38089273 T/A cg25427524 chr10:38739819 LOC399744 -0.66 -8.06 -0.41 1.44e-14 Obesity (extreme); CRC cis rs7772486 0.597 rs9386136 chr6:146158300 A/T cg23711669 chr6:146136114 FBXO30 0.66 9.83 0.48 3.67e-20 Lobe attachment (rater-scored or self-reported); CRC cis rs9896052 0.591 rs11077790 chr17:73464718 G/A cg23244877 chr17:73518230 TSEN54 0.44 6.97 0.36 1.74e-11 Sight-threatening diabetic retinopathy in type 2 diabetes; CRC cis rs1048238 0.935 rs761760 chr1:16342419 A/G cg10494257 chr1:16342123 HSPB7 0.45 6.27 0.33 1.1e-9 Systolic blood pressure; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg00731619 chr6:158981954 TMEM181 0.47 6.96 0.36 1.9e-11 Response to antipsychotic treatment; CRC cis rs7043114 0.507 rs7856204 chr9:95173814 G/C cg14631576 chr9:95140430 CENPP -0.31 -5.89 -0.31 9.31e-9 Height; CRC cis rs6866344 0.697 rs11742808 chr5:178131658 G/A cg10224037 chr5:178157518 ZNF354A 0.76 10.89 0.51 8.67e-24 Neutrophil percentage of white cells; CRC cis rs2282802 0.685 rs12188849 chr5:139621570 G/A cg26211634 chr5:139558579 C5orf32 0.43 7.59 0.39 3.33e-13 Intelligence (multi-trait analysis); CRC cis rs6693567 0.565 rs834238 chr1:150366469 G/T cg15654264 chr1:150340011 RPRD2 0.43 6.42 0.33 4.74e-10 Migraine; CRC cis rs131805 1.000 rs3091397 chr22:50957520 C/T cg05418105 chr22:50981406 NA -0.53 -7.18 -0.37 4.78e-12 Granulocyte percentage of myeloid white cells; CRC cis rs9463078 0.845 rs1329713 chr6:45004028 A/C cg25276700 chr6:44698697 NA -0.28 -6.72 -0.35 8.09e-11 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; CRC cis rs7811142 1.000 rs68116612 chr7:100006493 G/A cg00814883 chr7:100076585 TSC22D4 -0.71 -9.27 -0.45 2.6e-18 Platelet count; CRC cis rs2204008 0.807 rs8186948 chr12:38325101 C/G cg13010199 chr12:38710504 ALG10B 0.46 6.3 0.33 9.4e-10 Bladder cancer; CRC cis rs6089584 0.888 rs6089623 chr20:60615759 A/G cg13770153 chr20:60521292 NA -0.61 -9.17 -0.45 5.16e-18 Body mass index; CRC cis rs13108904 0.517 rs4974551 chr4:1336410 C/A cg24560729 chr4:1342394 KIAA1530 0.38 6.13 0.32 2.53e-9 Obesity-related traits; CRC cis rs4713118 0.629 rs172165 chr6:28020814 T/G cg18032046 chr6:28092343 ZSCAN16 -0.47 -6.07 -0.32 3.49e-9 Parkinson's disease; CRC cis rs4853012 0.838 rs4429500 chr2:74345336 A/G cg05890377 chr2:74357713 NA 0.58 9.8 0.48 4.47e-20 Gestational age at birth (maternal effect); CRC cis rs853679 0.517 rs4713144 chr6:28106790 C/G cg18032046 chr6:28092343 ZSCAN16 -0.52 -6.08 -0.32 3.3e-9 Depression; CRC trans rs7615952 0.546 rs2976733 chr3:125414138 T/C cg03844506 chr4:4109441 NA -0.51 -7.58 -0.39 3.65e-13 Blood pressure (smoking interaction); CRC cis rs1129187 0.755 rs9462856 chr6:42926024 T/C cg02353165 chr6:42928485 GNMT 0.71 11.6 0.54 2.58e-26 Alzheimer's disease in APOE e4+ carriers; CRC cis rs9522267 0.535 rs9515452 chr13:112234553 A/G cg14352298 chr13:112236639 NA 0.29 6.67 0.35 1.06e-10 Hepatitis; CRC cis rs78456975 1.000 rs6730391 chr2:1566838 A/C cg26248373 chr2:1572462 NA -0.72 -8.17 -0.41 6.78e-15 Placebo response in major depressive disorder (% change in symptom score); CRC cis rs1707322 0.752 rs12062535 chr1:46222880 G/A cg06784218 chr1:46089804 CCDC17 0.65 12.16 0.56 2.46e-28 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs7312933 0.703 rs1059360 chr12:42554505 A/G cg11827402 chr12:42719852 PPHLN1;ZCRB1 0.63 8.8 0.44 8.09e-17 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CRC cis rs10499694 0.933 rs11575334 chr7:50597301 G/A cg18232548 chr7:50535776 DDC -0.4 -6.18 -0.32 1.92e-9 Body mass index; CRC trans rs35110281 0.782 rs2838329 chr21:45023329 T/C cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.5 8.25 0.41 3.9e-15 Mean corpuscular volume; CRC cis rs3772130 0.962 rs4311252 chr3:121514161 A/G cg20356878 chr3:121714668 ILDR1 0.5 7.83 0.4 6.85e-14 Cognitive performance; CRC cis rs10504229 0.683 rs7843919 chr8:58130792 T/C cg05313129 chr8:58192883 C8orf71 -0.43 -6.11 -0.32 2.74e-9 Developmental language disorder (linguistic errors); CRC trans rs2553218 0.690 rs8032415 chr15:54851945 A/G cg04062187 chr1:167424664 CD247 0.44 6.04 0.32 4.1e-9 Immune response to smallpox vaccine (IL-6); CRC cis rs7666738 0.830 rs13141752 chr4:98893128 G/A cg17366294 chr4:99064904 C4orf37 0.42 6.91 0.36 2.5e-11 Colonoscopy-negative controls vs population controls; CRC cis rs10791097 0.935 rs4601795 chr11:130729430 T/C cg12179176 chr11:130786555 SNX19 0.59 9.33 0.46 1.66e-18 Autism spectrum disorder or schizophrenia;Schizophrenia; CRC cis rs780096 0.526 rs1406295 chr2:27689700 A/G cg02592271 chr2:27665507 KRTCAP3 -0.28 -6.58 -0.34 1.83e-10 Total body bone mineral density; CRC trans rs61931739 0.517 rs11513519 chr12:34075077 G/A cg26384229 chr12:38710491 ALG10B 0.54 6.86 0.35 3.41e-11 Morning vs. evening chronotype; CRC cis rs10504073 0.669 rs4493917 chr8:50015846 C/T cg00325661 chr8:49890786 NA 0.52 9.3 0.46 1.98e-18 Blood metabolite ratios; CRC cis rs7772486 0.754 rs9399567 chr6:146147295 C/T cg05347473 chr6:146136440 FBXO30 0.38 5.86 0.31 1.15e-8 Lobe attachment (rater-scored or self-reported); CRC cis rs977987 0.806 rs11865004 chr16:75395777 C/T cg03315344 chr16:75512273 CHST6 0.53 8.89 0.44 4.14e-17 Dupuytren's disease; CRC cis rs6988636 1.000 rs6983795 chr8:124185296 T/C cg27053337 chr8:124217698 FAM83A 0.45 6.84 0.35 3.77e-11 Urinary uromodulin levels; CRC cis rs617791 0.508 rs10896074 chr11:65776304 C/T cg09783858 chr11:65769428 EIF1AD;BANF1 0.5 7.45 0.38 8.11e-13 Breast cancer; CRC cis rs644799 0.932 rs572015 chr11:95637416 T/A cg03916912 chr11:95522834 CEP57;FAM76B 0.94 17.63 0.7 1.85e-49 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC trans rs783540 1.000 rs698500 chr15:83237769 T/C cg18393722 chr15:85113863 UBE2QP1 -0.39 -6.53 -0.34 2.5e-10 Schizophrenia; CRC cis rs28386778 0.897 rs2665796 chr17:61923716 G/C cg11494091 chr17:61959527 GH2 0.6 10.33 0.49 7.77e-22 Prudent dietary pattern; CRC cis rs17253792 0.822 rs118027213 chr14:56039076 T/C cg01858014 chr14:56050164 KTN1 -0.88 -6.83 -0.35 4.04e-11 Putamen volume; CRC cis rs9818758 0.607 rs80170003 chr3:48951640 T/C cg07636037 chr3:49044803 WDR6 -0.84 -6.32 -0.33 8.46e-10 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; CRC cis rs7666738 0.830 rs4699590 chr4:98974030 A/C cg05340658 chr4:99064831 C4orf37 0.59 9.17 0.45 5.34e-18 Colonoscopy-negative controls vs population controls; CRC cis rs7605827 0.897 rs7586068 chr2:15596747 T/A cg19274914 chr2:15703543 NA 0.39 5.92 0.31 8.31e-9 Educational attainment (years of education); CRC cis rs6570726 0.935 rs454370 chr6:145846729 T/G cg05347473 chr6:146136440 FBXO30 0.38 6.09 0.32 3.19e-9 Lobe attachment (rater-scored or self-reported); CRC trans rs61931739 0.500 rs11519123 chr12:34436478 A/G cg13010199 chr12:38710504 ALG10B 0.45 6.46 0.34 3.76e-10 Morning vs. evening chronotype; CRC cis rs1448094 0.533 rs10863078 chr12:86152672 C/T cg06740227 chr12:86229804 RASSF9 -0.38 -5.78 -0.3 1.74e-8 Major depressive disorder; CRC cis rs2233152 0.610 rs10405596 chr19:41314720 C/T cg21869046 chr19:41225005 ITPKC 0.37 5.73 0.3 2.21e-8 Kawasaki disease; CRC cis rs13108904 0.935 rs6853002 chr4:1295991 C/T cg02018176 chr4:1364513 KIAA1530 0.43 7.25 0.37 3.07e-12 Obesity-related traits; CRC trans rs11098499 0.722 rs7673476 chr4:120248683 C/T cg25214090 chr10:38739885 LOC399744 0.49 7.56 0.38 4e-13 Corneal astigmatism; CRC cis rs8177253 0.507 rs4241357 chr3:133475563 A/C cg11941060 chr3:133502564 NA 0.43 7.21 0.37 3.81e-12 Iron status biomarkers; CRC cis rs1003719 0.646 rs2835672 chr21:38581234 T/C cg10648535 chr21:38446584 PIGP;TTC3 -0.45 -6.23 -0.32 1.41e-9 Eye color traits; CRC cis rs9527 0.590 rs12415199 chr10:104895536 T/C cg04362960 chr10:104952993 NT5C2 0.6 8.32 0.42 2.32e-15 Arsenic metabolism; CRC cis rs2857891 0.909 rs56026267 chr11:6940211 T/C cg12728517 chr11:6947552 ZNF215 0.55 5.81 0.31 1.48e-8 Response to cytadine analogues (cytosine arabinoside); CRC cis rs394563 0.967 rs420099 chr6:149794290 A/C cg07828024 chr6:149772892 ZC3H12D -0.48 -8.43 -0.42 1.07e-15 Dupuytren's disease; CRC cis rs7224685 0.530 rs7221574 chr17:4007543 T/C cg09597638 chr17:3907349 NA 0.44 5.61 0.3 4.26e-8 Type 2 diabetes; CRC cis rs4713118 0.629 rs149899 chr6:28019979 C/T cg12273811 chr6:28175739 NA 0.61 8.39 0.42 1.45e-15 Parkinson's disease; CRC cis rs6496667 0.697 rs62020725 chr15:90980980 C/T cg04176472 chr15:90893244 GABARAPL3 0.6 6.54 0.34 2.42e-10 Rheumatoid arthritis; CRC cis rs60871478 0.898 rs62432225 chr7:789433 G/A cg13798912 chr7:905769 UNC84A 0.52 6.12 0.32 2.66e-9 Cerebrospinal P-tau181p levels; CRC cis rs17711722 0.522 rs4642526 chr7:65216742 G/T cg02869306 chr7:64672164 INTS4L1 -0.47 -8.14 -0.41 8.41e-15 Calcium levels; CRC cis rs4843747 0.671 rs28671027 chr16:88116323 G/A cg03395651 chr16:88107091 BANP 0.54 7.2 0.37 4.2e-12 Menopause (age at onset); CRC cis rs72781680 0.898 rs72796152 chr2:23933626 G/A cg08917208 chr2:24149416 ATAD2B 0.85 8.14 0.41 8.34e-15 Lymphocyte counts; CRC cis rs17401966 0.800 rs12122029 chr1:10339822 G/A cg19773385 chr1:10388646 KIF1B -0.67 -11.11 -0.52 1.45e-24 Hepatocellular carcinoma; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg24669129 chr7:155089712 INSIG1 0.42 6.65 0.34 1.23e-10 Intelligence (multi-trait analysis); CRC cis rs6835098 0.924 rs12639929 chr4:174156538 C/T cg08422745 chr4:174089978 GALNT7 -0.94 -14.4 -0.62 8.52e-37 Dementia and core Alzheimer's disease neuropathologic changes; CRC cis rs758324 0.947 rs7734536 chr5:131162124 C/T cg06307176 chr5:131281290 NA 0.42 6.23 0.32 1.45e-9 Alzheimer's disease in APOE e4- carriers; CRC cis rs9916302 0.861 rs11078912 chr17:37671490 A/G cg00129232 chr17:37814104 STARD3 -0.54 -7.99 -0.4 2.22e-14 Glomerular filtration rate (creatinine); CRC cis rs6429082 0.667 rs10802800 chr1:235706283 A/G cg26050004 chr1:235667680 B3GALNT2 -0.5 -6.05 -0.32 3.87e-9 Adiposity; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg19545258 chr7:73703601 CLIP2 0.36 6.09 0.32 3.13e-9 Liver disease severity in Alagille syndrome; CRC cis rs6496667 0.779 rs28408607 chr15:90919000 T/C cg04176472 chr15:90893244 GABARAPL3 0.57 7.88 0.4 4.93e-14 Rheumatoid arthritis; CRC cis rs2576037 1.000 rs2576037 chr18:44585420 C/T cg19077165 chr18:44547161 KATNAL2 0.51 8.03 0.41 1.69e-14 Personality dimensions; CRC cis rs6860806 0.507 rs272883 chr5:131668698 A/G cg22638593 chr5:131593259 PDLIM4 0.38 6.24 0.33 1.33e-9 Breast cancer; CRC cis rs1018836 0.923 rs6989123 chr8:91551234 A/T cg16814680 chr8:91681699 NA -0.76 -12.67 -0.57 3.03e-30 Ejection fraction in Tripanosoma cruzi seropositivity; CRC cis rs7216064 1.000 rs60432293 chr17:65860407 T/C cg12091567 chr17:66097778 LOC651250 -0.63 -7.9 -0.4 4.2e-14 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CRC cis rs1799949 0.930 rs4445938 chr17:41337900 A/C cg01879757 chr17:41196368 BRCA1 -0.44 -6.71 -0.35 8.4e-11 Menopause (age at onset); CRC cis rs4988958 0.565 rs1420100 chr2:103037002 C/A cg03938978 chr2:103052716 IL18RAP 0.59 10.13 0.49 3.5e-21 Asthma (childhood onset); CRC trans rs10504229 1.000 rs59383954 chr8:58189689 G/A cg04077850 chr5:125800366 GRAMD3 0.37 6.27 0.33 1.15e-9 Developmental language disorder (linguistic errors); CRC cis rs4713118 0.621 rs4713134 chr6:28034121 T/C cg25164649 chr6:28176230 NA 0.7 8.93 0.44 3.12e-17 Parkinson's disease; CRC cis rs9858542 0.953 rs35261698 chr3:49537839 C/G cg07274523 chr3:49395745 GPX1 0.46 6.23 0.32 1.43e-9 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC trans rs7726839 0.540 rs12517638 chr5:645484 C/T cg11887960 chr12:57824829 NA 0.64 7.2 0.37 4.1e-12 Obesity-related traits; CRC cis rs6754459 0.603 rs11894441 chr2:3701972 A/G cg10645314 chr2:3704589 ALLC 0.5 6.82 0.35 4.37e-11 Response to inhaled corticosteroid treatment in asthma (change in FEV1); CRC cis rs11098499 0.954 rs11098526 chr4:120390359 C/T cg09307838 chr4:120376055 NA 0.7 10.8 0.51 1.74e-23 Corneal astigmatism; CRC cis rs524281 0.861 rs10896085 chr11:65913832 A/T cg14036092 chr11:66035641 RAB1B -0.46 -5.65 -0.3 3.43e-8 Electroencephalogram traits; CRC cis rs4594175 0.962 rs8008182 chr14:51608357 C/T cg23942311 chr14:51606299 NA 0.67 11.13 0.52 1.24e-24 Cancer; CRC cis rs7945705 0.967 rs10840148 chr11:8923528 C/T cg21881798 chr11:8931708 C11orf17;ST5 0.67 10.28 0.49 1.15e-21 Hemoglobin concentration; CRC cis rs7113874 0.569 rs10160430 chr11:8599876 G/T cg17679104 chr11:8615758 STK33 0.36 6.01 0.31 5.06e-9 Body mass index in physically active individuals;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs780096 0.506 rs2288155 chr2:27714526 T/C cg27432699 chr2:27873401 GPN1 -0.62 -9.48 -0.46 5.39e-19 Total body bone mineral density; CRC cis rs12024301 0.557 rs12048457 chr1:183625491 T/G cg11505048 chr1:183622726 RGL1;APOBEC4 0.81 7.0 0.36 1.42e-11 Peripheral arterial disease (traffic-related air pollution interaction); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg04709655 chr2:122513098 TSN 0.46 6.68 0.35 9.97e-11 Intelligence (multi-trait analysis); CRC cis rs7727544 0.582 rs116749111 chr5:131462918 G/T cg02033258 chr5:131593261 PDLIM4 0.32 5.68 0.3 2.99e-8 Blood metabolite levels; CRC cis rs9902453 1.000 rs60967688 chr17:28437052 G/A cg26525008 chr17:28256777 EFCAB5;SSH2 0.61 9.41 0.46 8.68e-19 Coffee consumption (cups per day); CRC cis rs4692589 0.965 rs7657455 chr4:170958843 C/G cg19918862 chr4:170955249 NA 0.39 6.22 0.32 1.5e-9 Anxiety disorder; CRC cis rs9807841 0.592 rs1053007 chr19:10754400 A/G cg17710535 chr19:10819994 QTRT1 0.45 6.56 0.34 2.06e-10 Inflammatory skin disease; CRC cis rs951366 0.764 rs823143 chr1:205743425 A/C cg14893161 chr1:205819251 PM20D1 0.83 13.48 0.6 2.7e-33 Menarche (age at onset); CRC cis rs7809950 0.678 rs7788271 chr7:106985873 A/G cg23024343 chr7:107201750 COG5 -0.75 -10.24 -0.49 1.5e-21 Coronary artery disease; CRC cis rs5769707 0.554 rs10854876 chr22:50010570 T/C cg20744362 chr22:50050164 C22orf34 0.33 5.96 0.31 6.37e-9 Monocyte count;Monocyte percentage of white cells; CRC cis rs2204008 0.529 rs1315350 chr12:38164282 C/A cg26384229 chr12:38710491 ALG10B -0.57 -8.32 -0.42 2.39e-15 Bladder cancer; CRC cis rs11212617 0.837 rs2070661 chr11:108043988 C/T cg01991180 chr11:108092276 ATM;NPAT 0.42 6.23 0.32 1.42e-9 Response to metformin in type 2 diabetes (glycemic); CRC cis rs4629180 0.675 rs6707298 chr2:102089738 A/G cg04415270 chr2:102091202 RFX8 0.35 6.01 0.31 4.82e-9 Chronic rhinosinusitis with nasal polyps; CRC trans rs2303319 0.504 rs62189046 chr2:162612371 C/G cg13490827 chr1:46269305 MAST2 -0.69 -6.0 -0.31 5.24e-9 Cognitive function; CRC cis rs12188164 0.900 rs72717425 chr5:438809 C/T cg21972741 chr5:435613 AHRR 0.5 6.99 0.36 1.51e-11 Cystic fibrosis severity; CRC cis rs7937682 0.632 rs4936800 chr11:111734097 T/A cg19812747 chr11:111475976 SIK2 0.42 6.24 0.33 1.38e-9 Primary sclerosing cholangitis; CRC cis rs10489525 0.583 rs6660550 chr1:115650850 C/G cg01522456 chr1:115632236 TSPAN2 0.66 9.83 0.48 3.8e-20 Autism; CRC cis rs66573146 1.000 rs66573146 chr4:6984464 C/G cg00086871 chr4:6988644 TBC1D14 1.02 7.68 0.39 1.81e-13 Granulocyte percentage of myeloid white cells; CRC trans rs1814175 0.619 rs847644 chr11:49918418 G/A cg11707556 chr5:10655725 ANKRD33B -0.52 -9.95 -0.48 1.49e-20 Height; CRC cis rs7215564 0.730 rs4889877 chr17:78662459 A/C cg09596252 chr17:78655493 RPTOR 0.54 6.08 0.32 3.41e-9 Myopia (pathological); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg22929104 chr3:101396044 ZBTB11;LOC100009676 0.46 6.76 0.35 6.4e-11 Intelligence (multi-trait analysis); CRC cis rs780096 0.526 rs1260341 chr2:27663215 T/A cg02592271 chr2:27665507 KRTCAP3 -0.29 -6.69 -0.35 9.47e-11 Total body bone mineral density; CRC cis rs798554 1.000 rs798559 chr7:2758341 T/C cg14895029 chr7:2775587 GNA12 -0.41 -6.14 -0.32 2.34e-9 Height; CRC cis rs2346177 0.874 rs4953372 chr2:46651624 C/G cg26688816 chr2:46740690 ATP6V1E2 0.5 7.46 0.38 7.86e-13 HDL cholesterol; CRC cis rs40363 0.857 rs55989968 chr16:3530658 C/G cg05754148 chr16:3507555 NAT15 0.75 8.2 0.41 5.31e-15 Tuberculosis; CRC cis rs1862618 0.802 rs4389648 chr5:56103602 A/G cg20203395 chr5:56204925 C5orf35 -0.72 -8.49 -0.42 7.3e-16 Initial pursuit acceleration; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg20592700 chr7:5230083 WIPI2 0.45 7.12 0.37 6.98e-12 Liver disease severity in Alagille syndrome; CRC cis rs8060686 0.858 rs2008173 chr16:67856240 A/G cg26727032 chr16:67993705 SLC12A4 -0.69 -11.2 -0.53 7.17e-25 HDL cholesterol;Metabolic syndrome; CRC cis rs75804782 0.641 rs56396448 chr2:239335234 C/T cg18131467 chr2:239335373 ASB1 -0.7 -6.18 -0.32 1.91e-9 Morning vs. evening chronotype;Chronotype; CRC cis rs79057730 0.527 rs35316052 chr7:802954 C/T cg05729249 chr7:766119 PRKAR1B;HEATR2 0.7 7.16 0.37 5.26e-12 Initial pursuit acceleration; CRC cis rs17345786 1.000 rs17345786 chr3:101318318 A/C cg12386194 chr3:101231763 SENP7 -0.56 -7.32 -0.37 1.93e-12 Colonoscopy-negative controls vs population controls; CRC cis rs1050631 0.564 rs8098627 chr18:33721636 T/G cg25426722 chr18:33708991 SLC39A6;ELP2 0.37 5.69 0.3 2.8e-8 Esophageal squamous cell cancer (length of survival); CRC cis rs9462846 0.887 rs7758576 chr6:42871056 G/A cg21280719 chr6:42927975 GNMT -0.33 -6.47 -0.34 3.65e-10 Blood protein levels; CRC cis rs11098499 0.754 rs1511025 chr4:120240238 T/C cg09307838 chr4:120376055 NA 0.62 9.75 0.47 6.92e-20 Corneal astigmatism; CRC cis rs4423214 0.840 rs1792226 chr11:71176574 C/T cg05163923 chr11:71159392 DHCR7 -0.64 -7.64 -0.39 2.32e-13 Vitamin D levels; CRC cis rs10751667 0.666 rs6597962 chr11:976351 C/T cg01483505 chr11:975446 AP2A2 0.42 6.81 0.35 4.75e-11 Alzheimer's disease (late onset); CRC cis rs7552404 1.000 rs11161510 chr1:76210289 A/G cg22875332 chr1:76189707 ACADM -0.69 -9.33 -0.46 1.64e-18 Blood metabolite levels;Acylcarnitine levels; CRC cis rs34172651 0.517 rs2287783 chr16:24831727 C/T cg06505273 chr16:24850292 NA 0.53 6.93 0.36 2.21e-11 Intelligence (multi-trait analysis); CRC cis rs7829975 0.659 rs4382480 chr8:8721473 C/T cg14979609 chr8:8086686 FLJ10661 -0.36 -5.78 -0.3 1.77e-8 Mood instability; CRC cis rs1552244 1.000 rs9827740 chr3:10120531 T/C cg08888203 chr3:10149979 C3orf24 0.7 10.07 0.49 5.94e-21 Alzheimer's disease; CRC cis rs10463316 0.894 rs3846712 chr5:150759813 C/A cg03212797 chr5:150827313 SLC36A1 -0.5 -7.93 -0.4 3.57e-14 Metabolite levels (Pyroglutamine); CRC cis rs1552244 1.000 rs7628448 chr3:10146828 G/A cg10729496 chr3:10149963 C3orf24 0.57 7.26 0.37 2.75e-12 Alzheimer's disease; CRC cis rs4363385 0.747 rs946097 chr1:152974732 A/G cg25856811 chr1:152973957 SPRR3 -0.26 -7.22 -0.37 3.62e-12 Inflammatory skin disease; CRC cis rs11098699 0.821 rs4833886 chr4:124206263 A/C cg09941581 chr4:124220074 SPATA5 0.4 5.87 0.31 1.08e-8 Mosquito bite size; CRC trans rs7395662 1.000 rs7479498 chr11:48660499 G/A cg21153622 chr11:89784906 NA -0.45 -7.23 -0.37 3.3e-12 HDL cholesterol; CRC cis rs6424115 0.830 rs2502994 chr1:24199363 T/C cg10978503 chr1:24200527 CNR2 0.62 11.34 0.53 2.2e-25 Immature fraction of reticulocytes; CRC cis rs1451375 0.617 rs7790758 chr7:50561544 G/A cg18232548 chr7:50535776 DDC -0.44 -5.73 -0.3 2.27e-8 Malaria; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg07159286 chr12:133779169 ZNF268 -0.42 -6.88 -0.35 2.99e-11 Liver disease severity in Alagille syndrome; CRC trans rs10983614 1.000 rs7867776 chr9:120072627 A/G cg01742826 chr19:47104737 CALM3 0.45 6.06 0.32 3.8e-9 Survival in pancreatic cancer; CRC trans rs1728785 1.000 rs7192341 chr16:68569224 G/C cg04657470 chr2:198365150 HSPE1;HSPD1 0.77 8.93 0.44 3.04e-17 Ulcerative colitis; CRC cis rs6546550 0.900 rs2054047 chr2:70117421 A/C cg02498382 chr2:70120550 SNRNP27 -0.55 -9.19 -0.45 4.63e-18 Prevalent atrial fibrillation; CRC cis rs11758351 0.789 rs2069020 chr6:26205500 C/T cg01420254 chr6:26195488 NA 0.8 8.79 0.44 8.58e-17 Gout;Renal underexcretion gout; CRC cis rs4509693 1.000 rs6584392 chr10:102497166 G/A cg23167259 chr10:102495509 NA -0.46 -6.23 -0.32 1.41e-9 Alzheimer's disease; CRC cis rs9322193 0.923 rs62441303 chr6:150088683 A/G cg00933542 chr6:150070202 PCMT1 0.28 5.69 0.3 2.75e-8 Lung cancer; CRC cis rs11190604 0.725 rs9420796 chr10:102323092 G/C cg16342193 chr10:102329863 NA -0.35 -6.02 -0.31 4.7e-9 Palmitoleic acid (16:1n-7) levels; CRC trans rs2303319 0.504 rs62189055 chr2:162625749 C/A cg25193742 chr10:104614220 C10orf32 -0.76 -6.42 -0.33 4.8e-10 Cognitive function; CRC cis rs7107770 0.663 rs1078531 chr11:125073396 G/A cg27629782 chr11:125073726 PKNOX2 0.51 7.34 0.38 1.66e-12 Photic sneeze reflex; CRC cis rs995000 0.931 rs598253 chr1:62911341 T/C cg19896129 chr1:63156450 NA 0.44 6.8 0.35 4.87e-11 Triglyceride levels; CRC trans rs73162807 0.655 rs73160981 chr3:146428795 C/T cg26896787 chr1:228603707 TRIM17 -0.59 -5.99 -0.31 5.61e-9 Platelet-derived growth factor BB levels; CRC cis rs11190604 1.000 rs28522614 chr10:102323141 T/A cg16342193 chr10:102329863 NA -0.37 -6.11 -0.32 2.82e-9 Palmitoleic acid (16:1n-7) levels; CRC cis rs7945705 0.935 rs2653593 chr11:8877317 G/A cg21881798 chr11:8931708 C11orf17;ST5 -0.74 -12.52 -0.57 1.09e-29 Hemoglobin concentration; CRC trans rs208520 0.545 rs6899712 chr6:66749670 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 1.09 20.55 0.75 6.22e-61 Exhaled nitric oxide output; CRC cis rs6952808 1.000 rs10260585 chr7:1889521 G/A cg21782813 chr7:2030301 MAD1L1 0.45 7.53 0.38 4.87e-13 Bipolar disorder and schizophrenia; CRC cis rs9914988 0.887 rs8078402 chr17:27145124 T/A cg16670446 chr17:27188758 MIR451;MIR144 0.53 8.4 0.42 1.32e-15 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs10751667 0.666 rs7395402 chr11:950293 A/G ch.11.42038R chr11:967971 AP2A2 -0.55 -9.61 -0.47 1.97e-19 Alzheimer's disease (late onset); CRC cis rs2839186 0.588 rs7280110 chr21:47619039 G/A cg13012494 chr21:47604986 C21orf56 -0.48 -7.78 -0.39 9.72e-14 Testicular germ cell tumor; CRC cis rs1707322 1.000 rs11211235 chr1:46440375 G/A cg06784218 chr1:46089804 CCDC17 0.51 8.96 0.44 2.39e-17 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs28386778 0.897 rs2665823 chr17:61885917 G/A cg11494091 chr17:61959527 GH2 0.6 10.13 0.49 3.48e-21 Prudent dietary pattern; CRC cis rs1451375 0.583 rs3807555 chr7:50610569 A/G cg14593290 chr7:50529359 DDC 0.63 8.52 0.43 5.96e-16 Malaria; CRC cis rs4363385 0.720 rs6704498 chr1:152964740 C/A cg25856811 chr1:152973957 SPRR3 -0.26 -7.27 -0.37 2.72e-12 Inflammatory skin disease; CRC cis rs9462027 0.606 rs2395606 chr6:34778486 T/G cg07306190 chr6:34760872 UHRF1BP1 -0.34 -5.95 -0.31 6.95e-9 Systemic lupus erythematosus; CRC cis rs10193935 0.892 rs6744964 chr2:42441088 A/G cg27598129 chr2:42591480 NA -0.67 -7.78 -0.39 9.5e-14 Colonoscopy-negative controls vs population controls; CRC cis rs7843479 0.544 rs11135735 chr8:21791557 C/T cg16476235 chr8:21771668 DOK2 0.39 6.5 0.34 2.94e-10 Mean corpuscular volume; CRC cis rs3820068 0.603 rs6429767 chr1:15963334 G/A cg27534772 chr1:16042836 PLEKHM2 0.55 10.93 0.52 6.22e-24 Systolic blood pressure; CRC cis rs4727963 0.792 rs1525468 chr7:122716911 A/C cg03640110 chr7:122635026 TAS2R16 0.34 6.23 0.32 1.46e-9 Adverse response to chemotherapy (neutropenia/leucopenia) (docetaxel); CRC cis rs6484504 0.532 rs2761589 chr11:31311429 C/G cg14844989 chr11:31128820 NA 0.35 6.19 0.32 1.79e-9 Red blood cell count; CRC trans rs7618501 0.635 rs7635002 chr3:49989155 T/G cg21665057 chr3:196295764 WDR53;FBXO45 0.6 9.36 0.46 1.31e-18 Intelligence (multi-trait analysis); CRC cis rs28386778 0.897 rs8073515 chr17:61795328 A/C cg22520471 chr17:61851767 DDX42;CCDC47 0.72 11.12 0.52 1.36e-24 Prudent dietary pattern; CRC cis rs9457247 0.663 rs2282861 chr6:167440128 C/T cg07741184 chr6:167504864 NA 0.35 6.32 0.33 8.58e-10 Crohn's disease; CRC cis rs9611519 0.894 rs4821998 chr22:41468273 C/G cg03806693 chr22:41940476 POLR3H -0.59 -7.59 -0.39 3.22e-13 Neuroticism; CRC cis rs1552244 0.751 rs12715665 chr3:10021601 C/T cg02579736 chr3:10068473 FANCD2;CIDECP 0.86 11.36 0.53 1.81e-25 Alzheimer's disease; CRC cis rs9309711 0.643 rs4264589 chr2:3481098 G/T cg15506890 chr2:3487001 NA -0.54 -8.7 -0.43 1.58e-16 Neurofibrillary tangles; CRC cis rs612683 0.524 rs584350 chr1:100908324 A/G cg06223162 chr1:101003688 GPR88 0.38 6.95 0.36 1.92e-11 Breast cancer; CRC cis rs1552244 1.000 rs7652935 chr3:10151138 T/C cg02579736 chr3:10068473 FANCD2;CIDECP 1.04 13.81 0.61 1.49e-34 Alzheimer's disease; CRC cis rs870825 1.000 rs870823 chr4:185588195 G/A cg04058563 chr4:185651563 MLF1IP 0.72 7.33 0.37 1.79e-12 Blood protein levels; CRC cis rs2882667 0.929 rs34846849 chr5:138360578 T/C cg04439458 chr5:138467593 SIL1 -0.35 -5.91 -0.31 8.54e-9 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs2243480 0.901 rs58207111 chr7:65486723 C/T cg18252515 chr7:66147081 NA -1.1 -12.3 -0.56 7.15e-29 Diabetic kidney disease; CRC cis rs780096 0.526 rs75855890 chr2:27625005 G/T cg12000995 chr2:27665139 KRTCAP3 -0.3 -6.1 -0.32 3.04e-9 Total body bone mineral density; CRC trans rs2832077 0.689 rs2832055 chr21:30132382 C/G cg14791747 chr16:20752902 THUMPD1 -0.5 -7.16 -0.37 5.23e-12 Cognitive test performance; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg04582424 chr1:203764710 ZC3H11A 0.46 7.25 0.37 3.03e-12 Liver disease severity in Alagille syndrome; CRC cis rs908922 0.676 rs4845780 chr1:152488846 T/G cg09873164 chr1:152488093 CRCT1 0.38 6.24 0.33 1.35e-9 Hair morphology; CRC cis rs7618501 1.000 rs9855505 chr3:49792158 T/G cg24308560 chr3:49941425 MST1R 0.45 7.06 0.36 9.95e-12 Intelligence (multi-trait analysis); CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg03341697 chr11:94277138 FUT4 -0.52 -6.33 -0.33 8.09e-10 Diisocyanate-induced asthma; CRC cis rs200986 1 rs200986 chr6:27824766 G/C cg12273811 chr6:28175739 NA 0.55 7.79 0.39 8.91e-14 Autism spectrum disorder or schizophrenia; CRC cis rs11190604 1.000 rs7905961 chr10:102297391 G/C cg16342193 chr10:102329863 NA -0.34 -5.82 -0.31 1.37e-8 Palmitoleic acid (16:1n-7) levels; CRC cis rs7089973 0.604 rs58587374 chr10:116597572 A/G cg23260525 chr10:116636907 FAM160B1 0.35 8.12 0.41 9.56e-15 Bipolar disorder or attention deficit hyperactivity disorder; CRC cis rs950027 0.620 rs1145084 chr15:45675440 G/A cg21132104 chr15:45694354 SPATA5L1 0.39 5.64 0.3 3.73e-8 Response to fenofibrate (adiponectin levels); CRC cis rs300703 0.872 rs300752 chr2:209292 A/G cg21211680 chr2:198530 NA 0.82 8.04 0.41 1.63e-14 Blood protein levels; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg20840177 chr12:68042558 DYRK2 0.44 6.23 0.32 1.41e-9 Anxiety disorder; CRC cis rs4713118 0.662 rs149969 chr6:27977737 A/G cg21251018 chr6:28226885 NKAPL 0.45 6.8 0.35 4.83e-11 Parkinson's disease; CRC cis rs2836950 0.545 rs2836956 chr21:40623018 C/G cg17971929 chr21:40555470 PSMG1 0.53 7.5 0.38 5.95e-13 Menarche (age at onset); CRC cis rs2075371 0.830 rs12669960 chr7:133931782 A/G cg02659138 chr7:134003124 SLC35B4 0.37 6.21 0.32 1.62e-9 Mean platelet volume; CRC cis rs939658 0.805 rs11634903 chr15:79436192 C/T cg17916960 chr15:79447300 NA 0.47 7.55 0.38 4.39e-13 Refractive error; CRC trans rs9825823 0.617 rs2083264 chr3:61074229 A/G cg21194723 chr11:60681294 TMEM109 0.42 5.99 0.31 5.42e-9 Depressive symptom measurement or major depressive disorder; CRC cis rs703842 0.616 rs4760171 chr12:58225904 A/G cg00677455 chr12:58241039 CTDSP2 0.83 12.57 0.57 7.29e-30 Multiple sclerosis; CRC cis rs743757 1.000 rs6446206 chr3:50455470 G/A cg09545109 chr3:50388910 TUSC4;CYB561D2 0.43 6.13 0.32 2.55e-9 Diastolic blood pressure; CRC cis rs225245 0.755 rs7217565 chr17:34024707 C/A cg05299278 chr17:33885742 SLFN14 0.5 8.12 0.41 9.57e-15 Reticulocyte count;Reticulocyte fraction of red cells;High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells; CRC cis rs3764400 0.567 rs208011 chr17:46258345 A/G cg10706073 chr17:46328419 SKAP1 0.59 6.55 0.34 2.21e-10 Body mass index; CRC cis rs4332037 0.539 rs1533827 chr7:2074290 A/G cg23422044 chr7:1970798 MAD1L1 0.56 6.96 0.36 1.85e-11 Bipolar disorder; CRC cis rs2032447 0.517 rs7767546 chr6:25904067 T/C cg03264133 chr6:25882463 NA -0.74 -10.55 -0.5 1.34e-22 Intelligence (multi-trait analysis); CRC cis rs2739330 0.761 rs5760176 chr22:24402321 A/G cg15242686 chr22:24348715 GSTTP1 -0.55 -9.13 -0.45 7.21e-18 Liver enzyme levels (gamma-glutamyl transferase); CRC trans rs17685 0.753 rs11982200 chr7:75714883 T/C cg19862616 chr7:65841803 NCRNA00174 1.0 18.87 0.72 2.33e-54 Coffee consumption;Coffee consumption (cups per day); CRC cis rs7208859 0.673 rs9915963 chr17:29019643 C/T cg01831904 chr17:28903510 LRRC37B2 -0.53 -5.97 -0.31 6.27e-9 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs2014572 0.967 rs10427146 chr19:57755998 T/C cg24459738 chr19:57751996 ZNF805 -0.53 -8.19 -0.41 5.93e-15 Hyperactive-impulsive symptoms; CRC cis rs2322633 0.515 rs1892474 chr6:80862349 G/A cg08355045 chr6:80787529 NA 0.36 5.74 0.3 2.14e-8 Height; CRC cis rs10791323 0.569 rs1119852 chr11:133743022 C/A cg06766960 chr11:133703094 NA -0.35 -6.44 -0.33 4.33e-10 Childhood ear infection; CRC cis rs8060686 0.641 rs8064114 chr16:68240185 G/A cg08314208 chr16:67682810 RLTPR -0.51 -6.04 -0.32 4.13e-9 HDL cholesterol;Metabolic syndrome; CRC trans rs561341 1.000 rs72823787 chr17:30283809 A/T cg27661571 chr11:113659931 NA -0.96 -11.24 -0.53 5.07e-25 Hip circumference adjusted for BMI; CRC cis rs9457247 0.765 rs1060404 chr6:167429467 A/G cg23791538 chr6:167370224 RNASET2 -0.39 -5.92 -0.31 8.19e-9 Crohn's disease; CRC cis rs11971779 0.680 rs2355788 chr7:139101897 T/C cg07862535 chr7:139043722 LUC7L2 0.57 7.32 0.37 1.92e-12 Diisocyanate-induced asthma; CRC cis rs546131 0.890 rs496558 chr11:34826425 C/T cg24088639 chr11:34937564 PDHX;APIP -0.43 -6.02 -0.32 4.61e-9 Lung disease severity in cystic fibrosis; CRC cis rs3806843 0.735 rs2530240 chr5:140060547 T/C cg19875535 chr5:140030758 IK -0.64 -10.73 -0.51 3.05e-23 Depressive symptoms (multi-trait analysis); CRC cis rs9826463 0.582 rs73238130 chr3:142004004 G/A cg20824294 chr3:142316082 PLS1 0.36 5.72 0.3 2.38e-8 QRS duration in Tripanosoma cruzi seropositivity; CRC cis rs9916302 0.851 rs11870631 chr17:37645129 C/T cg00129232 chr17:37814104 STARD3 -0.55 -8.17 -0.41 6.79e-15 Glomerular filtration rate (creatinine); CRC cis rs9903692 0.505 rs208005 chr17:46239985 A/G cg10706073 chr17:46328419 SKAP1 0.6 6.5 0.34 3.05e-10 Pulse pressure; CRC cis rs344364 0.511 rs2982446 chr16:1947153 C/T cg00046913 chr16:1877150 HAGH;FAHD1 -0.6 -6.22 -0.32 1.53e-9 Glomerular filtration rate in chronic kidney disease; CRC cis rs929354 0.772 rs10230895 chr7:157007038 T/C cg17757837 chr7:157058334 UBE3C 0.74 12.62 0.57 4.92e-30 Body mass index; CRC trans rs2018683 0.707 rs10279610 chr7:28975696 C/G cg19402173 chr7:128379420 CALU 0.44 6.37 0.33 6.53e-10 Response to irinotecan and platinum-based chemotherapy in non-small-cell lung cancer; CRC cis rs6952808 0.692 rs10950473 chr7:1999453 G/A cg02951883 chr7:2050386 MAD1L1 -0.74 -11.81 -0.55 4.43e-27 Bipolar disorder and schizophrenia; CRC cis rs853679 0.517 rs2273564 chr6:28057594 A/T cg06470822 chr6:28175283 NA 1.0 13.31 0.59 1.27e-32 Depression; CRC cis rs8177253 1.000 rs1525892 chr3:133484712 C/T cg16262614 chr3:133464971 TF 0.33 5.84 0.31 1.24e-8 Iron status biomarkers; CRC cis rs9807989 0.839 rs7603730 chr2:102974371 A/C cg03938978 chr2:103052716 IL18RAP 0.38 6.29 0.33 9.85e-10 Asthma; CRC cis rs9488822 0.596 rs6568921 chr6:116373616 C/T cg15226275 chr6:116381976 FRK 0.27 7.27 0.37 2.69e-12 Cholesterol, total;LDL cholesterol; CRC cis rs12449964 0.524 rs4925092 chr17:17568931 A/G cg24612305 chr17:17875800 TOM1L2;LRRC48 0.37 5.62 0.3 4.05e-8 Coronary artery disease or ischemic stroke; CRC trans rs13046373 0.905 rs4816372 chr21:32077414 A/T cg17589124 chr1:6546732 PLEKHG5 -0.39 -6.0 -0.31 5.17e-9 HDL cholesterol; CRC cis rs2153535 0.580 rs9328486 chr6:8528008 T/C cg21535247 chr6:8435926 SLC35B3 0.48 7.35 0.38 1.6e-12 Motion sickness; CRC cis rs3087591 0.708 rs2854320 chr17:29694063 C/A cg24425628 chr17:29625626 OMG;NF1 0.69 12.73 0.57 1.87e-30 Hip circumference; CRC cis rs1163251 0.902 rs514491 chr1:120216743 C/T cg19096424 chr1:120255104 PHGDH 0.46 6.65 0.34 1.2e-10 Blood metabolite levels; CRC cis rs9457247 0.967 rs425039 chr6:167410527 C/T cg23791538 chr6:167370224 RNASET2 -0.39 -6.08 -0.32 3.37e-9 Crohn's disease; CRC cis rs7917772 0.503 rs7893155 chr10:104294228 C/A cg04362960 chr10:104952993 NT5C2 -0.41 -5.79 -0.3 1.62e-8 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC cis rs4481887 0.760 rs4559544 chr1:248412507 T/G cg13385794 chr1:248469461 NA 0.34 5.87 0.31 1.07e-8 Common traits (Other); CRC cis rs9921222 0.597 rs7193109 chr16:413523 T/G cg00101154 chr16:420108 MRPL28 -0.56 -8.03 -0.41 1.7e-14 Bone mineral density (spine);Bone mineral density; CRC cis rs763121 0.853 rs5750627 chr22:38982321 A/G cg06544989 chr22:39130855 UNC84B 0.47 7.58 0.39 3.51e-13 Menopause (age at onset); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg01199328 chr20:5107611 CDS2;PCNA 0.43 6.07 0.32 3.51e-9 Intelligence (multi-trait analysis); CRC cis rs4629180 1.000 rs4851457 chr2:102091220 C/T cg04415270 chr2:102091202 RFX8 0.62 8.71 0.43 1.54e-16 Chronic rhinosinusitis with nasal polyps; CRC cis rs736408 0.812 rs1075653 chr3:52825528 T/C cg11645453 chr3:52864694 ITIH4 0.47 8.38 0.42 1.59e-15 Bipolar disorder; CRC cis rs3126085 0.935 rs4534386 chr1:152251714 A/G cg09127314 chr1:152161683 NA 0.45 5.86 0.31 1.14e-8 Atopic dermatitis; CRC cis rs7647973 0.710 rs1491983 chr3:49639803 G/T cg03060546 chr3:49711283 APEH 0.64 7.54 0.38 4.52e-13 Menarche (age at onset); CRC trans rs3749237 1.000 rs11920900 chr3:49823024 G/C cg21659725 chr3:3221576 CRBN 0.54 7.34 0.38 1.65e-12 Resting heart rate; CRC trans rs2228479 0.850 rs12598276 chr16:89829196 G/C cg24644049 chr4:85504048 CDS1 0.86 6.93 0.36 2.29e-11 Skin colour saturation; CRC cis rs1158570 0.521 rs10089819 chr8:131172968 C/T cg15707833 chr8:131455276 NA -0.38 -5.72 -0.3 2.35e-8 Platelet count; CRC cis rs11148252 0.967 rs4286007 chr13:53022518 A/G cg02158880 chr13:53174818 NA 0.46 6.91 0.36 2.57e-11 Lewy body disease; CRC cis rs28595532 1.000 rs11098451 chr4:119717673 C/T cg14228332 chr4:119757509 SEC24D 0.74 5.67 0.3 3.13e-8 Cannabis dependence symptom count; CRC cis rs853679 0.542 rs9380063 chr6:28137853 A/G cg06470822 chr6:28175283 NA 1.03 13.59 0.6 1.04e-33 Depression; CRC trans rs3794271 0.706 rs9971816 chr12:20826911 C/T cg16402443 chr7:2598526 IQCE 0.43 6.06 0.32 3.65e-9 Response to TNF-alpha inhibitors in rheumatoid arthritis; CRC trans rs6598955 0.671 rs13374173 chr1:26602256 T/G cg07461501 chr17:79650226 HGS;ARL16 -0.52 -6.19 -0.32 1.77e-9 Obesity-related traits; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg26742440 chr11:73472391 RAB6A 0.49 7.17 0.37 5.12e-12 Response to antipsychotic treatment; CRC cis rs7071206 0.947 rs1356090 chr10:79395312 T/C cg07817648 chr10:79422355 NA -0.74 -9.44 -0.46 6.91e-19 Bone mineral density; CRC cis rs11585357 0.793 rs11587669 chr1:17616259 C/T cg08277548 chr1:17600880 PADI3 -0.89 -11.31 -0.53 2.94e-25 Hair shape; CRC cis rs7474896 0.559 rs1208645 chr10:38132087 C/T cg25427524 chr10:38739819 LOC399744 0.65 8.05 0.41 1.58e-14 Obesity (extreme); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg19345165 chr11:47600677 NDUFS3;KBTBD4 0.39 5.98 0.31 5.82e-9 Intelligence (multi-trait analysis); CRC cis rs344364 0.511 rs2917515 chr16:1945271 G/C cg14074117 chr16:1909714 C16orf73 0.49 6.52 0.34 2.59e-10 Glomerular filtration rate in chronic kidney disease; CRC cis rs2120019 0.938 rs13056 chr15:75312187 A/G cg11632617 chr15:75315747 PPCDC -0.57 -7.85 -0.4 5.77e-14 Blood trace element (Zn levels); CRC cis rs9747201 0.925 rs62078748 chr17:80055325 C/T cg02741985 chr17:80059408 CCDC57 -0.44 -5.74 -0.3 2.11e-8 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs7523050 0.643 rs67567504 chr1:109402580 C/A cg08274380 chr1:109419600 GPSM2 0.85 6.65 0.34 1.24e-10 Fat distribution (HIV); CRC cis rs7666738 0.791 rs13111960 chr4:98976851 C/T cg05340658 chr4:99064831 C4orf37 0.57 8.76 0.43 1.05e-16 Colonoscopy-negative controls vs population controls; CRC cis rs754466 0.651 rs10762767 chr10:79645070 C/A cg26805224 chr10:79626177 DLG5 -0.53 -7.91 -0.4 3.92e-14 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs2396545 0.680 rs35467761 chr11:571568 A/G cg07212818 chr11:638076 DRD4 -0.46 -5.85 -0.31 1.19e-8 Systemic lupus erythematosus and Systemic sclerosis; CRC cis rs13191362 0.872 rs13213421 chr6:163203805 A/G cg21926612 chr6:163149169 PACRG;PARK2 0.9 11.77 0.54 6.55e-27 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs992157 0.717 rs3817266 chr2:219142594 C/T cg13835894 chr2:219148914 PNKD;TMBIM1 -0.35 -6.76 -0.35 6.22e-11 Colorectal cancer; CRC cis rs10751667 0.666 rs7105477 chr11:964271 C/G cg01483505 chr11:975446 AP2A2 0.47 7.72 0.39 1.42e-13 Alzheimer's disease (late onset); CRC cis rs10504229 1.000 rs67705655 chr8:58177688 G/A cg02290350 chr8:58132656 NA -0.42 -5.96 -0.31 6.62e-9 Developmental language disorder (linguistic errors); CRC cis rs910316 1.000 rs175443 chr14:75601963 C/T cg08847533 chr14:75593920 NEK9 -0.89 -16.45 -0.67 8.22e-45 Height; CRC cis rs3793683 0.520 rs12769959 chr10:134579026 A/C cg06453172 chr10:134556979 INPP5A -0.58 -7.35 -0.38 1.58e-12 Migraine; CRC trans rs629535 0.814 rs477200 chr8:70059584 A/G cg21567404 chr3:27674614 NA 0.87 15.54 0.65 3.24e-41 Dupuytren's disease; CRC cis rs6460942 1.000 rs112794590 chr7:12319426 G/A cg06484146 chr7:12443880 VWDE -0.76 -7.53 -0.38 4.85e-13 Coronary artery disease; CRC cis rs198813 0.611 rs198823 chr6:26122933 G/T cg18357526 chr6:26021779 HIST1H4A -0.48 -6.84 -0.35 3.93e-11 Intelligence (multi-trait analysis); CRC cis rs12936587 0.569 rs8073683 chr17:17555596 C/T cg24612305 chr17:17875800 TOM1L2;LRRC48 -0.38 -5.82 -0.31 1.37e-8 Hip circumference;Coronary artery disease or large artery stroke;Coronary heart disease;Coronary artery disease; CRC cis rs3749237 0.595 rs4855839 chr3:49507847 G/A cg03060546 chr3:49711283 APEH 0.61 10.39 0.5 4.83e-22 Resting heart rate; CRC cis rs9549367 0.789 rs2302757 chr13:113909339 A/G cg18105134 chr13:113819100 PROZ -0.74 -10.5 -0.5 1.94e-22 Platelet distribution width; CRC cis rs7552404 1.000 rs11161511 chr1:76210477 A/G cg10523679 chr1:76189770 ACADM -0.83 -11.34 -0.53 2.26e-25 Blood metabolite levels;Acylcarnitine levels; CRC cis rs7927592 0.913 rs2236708 chr11:68378045 G/A cg01657329 chr11:68192670 LRP5 -0.46 -6.5 -0.34 2.91e-10 Total body bone mineral density; CRC trans rs10982213 0.830 rs2274163 chr9:117188714 C/T cg06522697 chr10:121356224 TIAL1 0.4 6.01 0.31 4.86e-9 Interleukin-6 levels; CRC trans rs10506458 0.834 rs55966529 chr12:63384114 A/C cg03429785 chr15:59498649 MYO1E;LDHAL6B -1.46 -20.67 -0.75 2.07e-61 Hemostatic factors and hematological phenotypes; CRC cis rs172166 0.637 rs1071893 chr6:28167635 G/C cg15786705 chr6:28176104 NA 0.68 10.33 0.49 7.66e-22 Cardiac Troponin-T levels; CRC cis rs4803468 1.000 rs10409485 chr19:41920765 C/T cg09537434 chr19:41945824 ATP5SL 0.96 18.55 0.71 4.63e-53 Height; CRC cis rs7617773 0.817 rs13072018 chr3:48320332 G/A cg11946769 chr3:48343235 NME6 0.72 9.6 0.47 2.12e-19 Coronary artery disease; CRC cis rs262150 0.574 rs2730273 chr7:158797754 A/C cg19418458 chr7:158789849 NA -0.51 -8.99 -0.44 1.97e-17 Facial morphology (factor 20); CRC trans rs1814175 0.715 rs10839409 chr11:49884647 G/T cg21153622 chr11:89784906 NA -0.38 -6.05 -0.32 3.92e-9 Height; CRC cis rs7572644 0.723 rs12473400 chr2:28024024 G/T cg27432699 chr2:27873401 GPN1 0.45 5.66 0.3 3.27e-8 Response to carboplatin and paclitaxel in ovarian cancer (Caspase 3/7 EC50); CRC trans rs2303319 0.504 rs62189048 chr2:162613494 G/C cg12500891 chr11:57225987 NA -0.65 -6.06 -0.32 3.77e-9 Cognitive function; CRC cis rs6952808 0.692 rs56727870 chr7:2029940 T/C cg02951883 chr7:2050386 MAD1L1 -0.78 -12.8 -0.58 1.04e-30 Bipolar disorder and schizophrenia; CRC cis rs2310173 0.575 rs757918 chr2:102613299 C/T cg20856504 chr2:102616538 IL1R2 0.36 5.69 0.3 2.74e-8 Ankylosing spondylitis;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined);Ulcerative colitis; CRC cis rs483180 0.531 rs539708 chr1:120208503 G/T cg19096424 chr1:120255104 PHGDH -0.45 -6.53 -0.34 2.46e-10 Macular telangiectasia type 2; CRC cis rs11148252 0.557 rs9536223 chr13:53233194 A/T cg02158880 chr13:53174818 NA 0.55 8.7 0.43 1.66e-16 Lewy body disease; CRC cis rs881375 0.967 rs1014529 chr9:123684943 C/G cg14255062 chr9:123606675 PSMD5;LOC253039 0.41 5.9 0.31 9.15e-9 Rheumatoid arthritis; CRC trans rs2228479 0.717 rs1061647 chr16:89806063 G/C cg21302420 chr1:112162376 RAP1A 0.73 5.98 0.31 5.83e-9 Skin colour saturation; CRC cis rs6952808 0.825 rs11761818 chr7:1935273 C/T cg04267008 chr7:1944627 MAD1L1 -0.84 -12.95 -0.58 2.89e-31 Bipolar disorder and schizophrenia; CRC cis rs644799 1.000 rs580255 chr11:95577929 T/C cg25478527 chr11:95522999 CEP57;FAM76B 0.52 7.81 0.4 7.74e-14 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs7781557 1.000 rs11496066 chr7:102486254 T/C cg18108683 chr7:102477205 FBXL13 -0.55 -6.97 -0.36 1.75e-11 Colorectal adenoma (advanced); CRC cis rs7786808 0.579 rs4045391 chr7:158181826 T/C cg01191920 chr7:158217561 PTPRN2 -0.71 -11.38 -0.53 1.57e-25 Obesity-related traits; CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg15045943 chr5:171614719 STK10 -0.54 -6.63 -0.34 1.39e-10 Diisocyanate-induced asthma; CRC cis rs7772486 0.754 rs4566902 chr6:146244128 A/G cg23711669 chr6:146136114 FBXO30 -0.72 -12.64 -0.57 3.92e-30 Lobe attachment (rater-scored or self-reported); CRC cis rs4938330 0.600 rs2239010 chr11:117089006 G/C cg01368799 chr11:117014884 PAFAH1B2 -0.47 -6.04 -0.32 4.26e-9 Blood protein levels; CRC cis rs826838 1.000 rs826889 chr12:39101076 G/A cg13010199 chr12:38710504 ALG10B -0.4 -5.9 -0.31 8.82e-9 Heart rate; CRC cis rs757110 0.803 rs7928810 chr11:17372443 G/T cg15432903 chr11:17409602 KCNJ11 0.77 11.86 0.55 2.99e-27 Type 2 diabetes; CRC cis rs12142240 0.698 rs56358525 chr1:46849520 C/T cg14993813 chr1:46806288 NSUN4 -0.48 -6.08 -0.32 3.39e-9 Menopause (age at onset); CRC cis rs2282802 0.685 rs4913079 chr5:139683029 A/G cg26211634 chr5:139558579 C5orf32 0.44 7.75 0.39 1.18e-13 Intelligence (multi-trait analysis); CRC cis rs17401966 0.838 rs4846209 chr1:10322054 G/A cg19773385 chr1:10388646 KIF1B -0.68 -11.1 -0.52 1.53e-24 Hepatocellular carcinoma; CRC cis rs3862030 0.839 rs2274351 chr10:104264107 C/T cg11453585 chr10:104263688 ACTR1A;SUFU -0.77 -13.34 -0.59 9.15e-33 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for body mass index; CRC cis rs4665809 1.000 rs6546736 chr2:26293878 C/T cg25036284 chr2:26402008 FAM59B 0.46 6.03 0.32 4.29e-9 Gut microbiome composition (summer); CRC cis rs10504229 0.516 rs60398072 chr8:58086559 G/A cg20607798 chr8:58055168 NA 0.42 6.72 0.35 8.02e-11 Developmental language disorder (linguistic errors); CRC cis rs1348850 0.914 rs7565022 chr2:178320222 A/T cg02961200 chr2:178257176 LOC100130691;AGPS 0.58 8.49 0.42 7.34e-16 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs7558233 0.614 rs763456 chr2:23675180 A/G cg00747342 chr2:23700632 KLHL29 0.58 6.08 0.32 3.33e-9 Cannabis use (initiation); CRC cis rs300703 0.935 rs300704 chr2:240255 A/C cg21211680 chr2:198530 NA 0.98 8.49 0.42 7.39e-16 Blood protein levels; CRC cis rs10504229 0.683 rs6984765 chr8:58127124 T/C cg04204079 chr8:58130323 NA -0.45 -5.78 -0.3 1.71e-8 Developmental language disorder (linguistic errors); CRC cis rs28386778 0.897 rs2727295 chr17:61887693 C/T cg06601766 chr17:61851465 DDX42;CCDC47 0.44 6.19 0.32 1.75e-9 Prudent dietary pattern; CRC cis rs801193 0.569 rs2659892 chr7:66200305 A/G cg12463550 chr7:65579703 CRCP 0.45 6.12 0.32 2.72e-9 Aortic root size; CRC cis rs6565681 1.000 rs6565681 chr17:78348494 A/G cg15383979 chr17:78362278 RNF213;LOC100294362 -0.53 -5.98 -0.31 5.92e-9 Moyamoya disease; CRC cis rs7666738 1.000 rs7666738 chr4:98968077 C/T cg17366294 chr4:99064904 C4orf37 0.46 7.4 0.38 1.13e-12 Colonoscopy-negative controls vs population controls; CRC cis rs3806843 1.000 rs3733708 chr5:140181734 A/G cg16607685 chr5:140181889 PCDHA2;PCDHA1;PCDHA3 -0.26 -5.97 -0.31 6.03e-9 Depressive symptoms (multi-trait analysis); CRC cis rs798554 0.757 rs1182178 chr7:2873763 G/A cg19717773 chr7:2847554 GNA12 -0.49 -6.98 -0.36 1.59e-11 Height; CRC cis rs4862750 0.872 rs6811569 chr4:187897988 A/G cg10295955 chr4:187884368 NA 1.06 26.73 0.83 1.79e-84 Lobe attachment (rater-scored or self-reported); CRC cis rs7705042 0.865 rs2043280 chr5:141513691 C/G cg07392085 chr5:141489673 NDFIP1 -0.46 -7.32 -0.37 1.87e-12 Asthma; CRC cis rs4665809 0.878 rs35709953 chr2:26334997 G/A cg25036284 chr2:26402008 FAM59B 0.54 6.41 0.33 5.04e-10 Gut microbiome composition (summer); CRC cis rs514406 0.679 rs960570 chr1:53237763 A/G cg27535305 chr1:53392650 SCP2 0.47 8.53 0.43 5.33e-16 Monocyte count; CRC cis rs4862750 0.837 rs1863404 chr4:187874654 T/C cg22105103 chr4:187893119 NA 0.6 10.88 0.51 9.1e-24 Lobe attachment (rater-scored or self-reported); CRC cis rs9814567 0.865 rs9834981 chr3:134282279 T/G cg06541857 chr3:134203789 ANAPC13;CEP63 -0.4 -6.09 -0.32 3.14e-9 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs6424115 0.594 rs10799802 chr1:24009544 C/T cg15997130 chr1:24165203 NA 0.5 6.7 0.35 9.13e-11 Immature fraction of reticulocytes; CRC cis rs2456568 0.709 rs1354765 chr11:93637776 G/T cg26875233 chr11:93583750 C11orf90 0.3 5.67 0.3 3.1e-8 Response to serotonin reuptake inhibitors in major depressive disorder; CRC cis rs5750830 0.594 rs9611169 chr22:39783027 C/T cg25459000 chr22:39777742 SYNGR1 -0.33 -6.06 -0.32 3.67e-9 Intelligence (multi-trait analysis); CRC cis rs7917772 0.503 rs11191328 chr10:104305185 C/T cg11453585 chr10:104263688 ACTR1A;SUFU 0.9 17.35 0.69 2.41e-48 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC cis rs2760061 0.819 rs1745417 chr1:228204279 C/T cg01200585 chr1:228362443 C1orf69 0.38 5.65 0.3 3.47e-8 Diastolic blood pressure; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg06529459 chr11:67397595 NUDT8 0.37 6.1 0.32 3.06e-9 Liver disease severity in Alagille syndrome; CRC cis rs9311474 1.000 rs1060330 chr3:52288945 T/C cg18099408 chr3:52552593 STAB1 -0.46 -7.81 -0.4 7.84e-14 Electroencephalogram traits; CRC cis rs10078 0.571 rs890973 chr5:471494 T/C cg26072250 chr5:443457 EXOC3;C5orf55 0.58 5.73 0.3 2.25e-8 Fat distribution (HIV); CRC cis rs7264396 0.887 rs224360 chr20:34059675 C/T cg04508476 chr20:34239394 CPNE1;RBM12 0.41 6.76 0.35 6.12e-11 Total cholesterol levels; CRC cis rs11098499 0.618 rs35265692 chr4:120325135 T/C cg24375607 chr4:120327624 NA 0.52 7.82 0.4 7.41e-14 Corneal astigmatism; CRC cis rs4718428 0.705 rs4717331 chr7:66378886 C/T cg18252515 chr7:66147081 NA -0.52 -7.26 -0.37 2.86e-12 Corneal structure; CRC cis rs6951245 0.572 rs75818004 chr7:1047572 C/T cg21664854 chr7:1097933 C7orf50;GPR146 0.73 5.68 0.3 2.91e-8 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs7737355 0.812 rs11750704 chr5:130911578 C/A cg25547332 chr5:131281432 NA 0.37 5.73 0.3 2.28e-8 Life satisfaction; CRC cis rs2857891 0.817 rs1491829 chr11:6968941 T/A cg04053776 chr11:6947353 ZNF215 0.38 5.6 0.3 4.5e-8 Response to cytadine analogues (cytosine arabinoside); CRC cis rs17376456 0.825 rs10072232 chr5:93398890 G/A cg25358565 chr5:93447407 FAM172A 1.02 10.4 0.5 4.25e-22 Diabetic retinopathy; CRC cis rs4862750 0.872 rs6553030 chr4:187899234 T/C cg06074448 chr4:187884817 NA -0.6 -11.3 -0.53 2.95e-25 Lobe attachment (rater-scored or self-reported); CRC cis rs62229266 0.740 rs4817759 chr21:37389559 G/A cg12218747 chr21:37451666 NA -0.41 -7.0 -0.36 1.46e-11 Mitral valve prolapse; CRC cis rs2070488 0.761 rs6807940 chr3:38460062 C/G cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.73 12.3 0.56 7.55e-29 Electrocardiographic conduction measures; CRC cis rs12618769 0.652 rs3820941 chr2:99233781 C/T cg18455616 chr2:99124870 INPP4A 0.36 5.91 0.31 8.32e-9 Bipolar disorder; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg01965872 chr20:33291894 TP53INP2 0.45 5.96 0.31 6.43e-9 Anxiety disorder; CRC cis rs2495707 0.624 rs2489007 chr10:102422046 A/G cg08729031 chr10:102416179 NA 0.43 7.58 0.39 3.6e-13 Body mass index; CRC cis rs9467711 0.606 rs9379855 chr6:26364930 C/T cg16898833 chr6:26189333 HIST1H4D -0.77 -6.56 -0.34 2.03e-10 Autism spectrum disorder or schizophrenia; CRC cis rs1552244 1.000 rs113522867 chr3:10154503 T/C cg08888203 chr3:10149979 C3orf24 0.7 9.49 0.46 4.97e-19 Alzheimer's disease; CRC cis rs875971 0.862 rs1875057 chr7:65731855 A/G cg00343986 chr7:65444356 GUSB -0.45 -6.2 -0.32 1.72e-9 Aortic root size; CRC cis rs9733 0.596 rs6681990 chr1:150695929 A/G cg17724175 chr1:150552817 MCL1 0.57 9.12 0.45 7.76e-18 Tonsillectomy; CRC cis rs600626 0.636 rs10793125 chr11:75452364 C/T cg24262691 chr11:75473276 NA -0.47 -6.92 -0.36 2.33e-11 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CRC cis rs9826463 0.582 rs73238155 chr3:142073145 G/A cg20824294 chr3:142316082 PLS1 0.35 5.7 0.3 2.72e-8 QRS duration in Tripanosoma cruzi seropositivity; CRC cis rs1005277 0.579 rs1780146 chr10:38517874 C/A cg00409905 chr10:38381863 ZNF37A -0.64 -10.5 -0.5 1.92e-22 Extrinsic epigenetic age acceleration; CRC cis rs644799 1.000 rs527899 chr11:95529242 T/G cg25478527 chr11:95522999 CEP57;FAM76B 0.51 7.69 0.39 1.68e-13 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs6952808 0.792 rs4721184 chr7:1950784 T/C cg04267008 chr7:1944627 MAD1L1 -0.84 -12.64 -0.57 4.19e-30 Bipolar disorder and schizophrenia; CRC cis rs4604732 0.642 rs7549312 chr1:247640078 C/G cg02104434 chr1:247694406 LOC148824;OR2C3 0.42 6.69 0.35 9.39e-11 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CRC cis rs73206853 0.841 rs73206883 chr12:110849549 A/G cg12870014 chr12:110450643 ANKRD13A 0.77 8.56 0.43 4.24e-16 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC cis rs9296092 0.538 rs62405953 chr6:33524760 C/T cg13560919 chr6:33536144 NA -0.43 -6.1 -0.32 3.02e-9 Age at smoking initiation in chronic obstructive pulmonary disease; CRC cis rs916888 0.779 rs430685 chr17:44859148 T/C cg01570182 chr17:44337453 NA -1.07 -12.8 -0.58 9.93e-31 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC trans rs7618501 1.000 rs695238 chr3:49869158 A/C cg21659725 chr3:3221576 CRBN 0.91 17.77 0.7 5.22e-50 Intelligence (multi-trait analysis); CRC cis rs16852403 0.583 rs12071903 chr1:178095804 C/T cg00404053 chr1:178313656 RASAL2 0.6 7.55 0.38 4.22e-13 Childhood ear infection; CRC cis rs4713118 0.869 rs6922574 chr6:27693003 A/T cg25164649 chr6:28176230 NA 0.59 8.13 0.41 8.77e-15 Parkinson's disease; CRC cis rs11098499 0.863 rs12508173 chr4:120318526 T/C cg24375607 chr4:120327624 NA 0.5 7.67 0.39 1.93e-13 Corneal astigmatism; CRC cis rs668210 0.793 rs540584 chr11:65765866 C/G cg02202077 chr11:65769826 EIF1AD;BANF1 -0.56 -7.02 -0.36 1.29e-11 Cerebrospinal fluid biomarker levels; CRC cis rs1552244 1.000 rs66797209 chr3:10078526 G/A cg10729496 chr3:10149963 C3orf24 0.55 7.11 0.37 7.07e-12 Alzheimer's disease; CRC cis rs11098499 0.955 rs7684942 chr4:120162201 C/T cg24375607 chr4:120327624 NA 0.43 6.69 0.35 9.56e-11 Corneal astigmatism; CRC cis rs10504229 0.683 rs72649192 chr8:58110490 T/C cg08219700 chr8:58056026 NA 0.56 6.75 0.35 6.57e-11 Developmental language disorder (linguistic errors); CRC cis rs4975709 0.569 rs1684965 chr5:1865248 A/G cg11168104 chr5:1857477 NA -0.37 -6.42 -0.33 4.8e-10 Cardiovascular disease risk factors; CRC cis rs6772849 0.830 rs7633674 chr3:128355026 G/A cg08795948 chr3:128337044 NA 0.36 6.22 0.32 1.53e-9 Monocyte percentage of white cells;Monocyte count; CRC cis rs7208859 0.673 rs73263785 chr17:29214808 C/T cg14008862 chr17:28927542 LRRC37B2 0.54 5.68 0.3 2.91e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs11997175 0.545 rs7388496 chr8:33667898 A/G cg04338863 chr8:33670619 NA 0.39 6.18 0.32 1.88e-9 Body mass index; CRC cis rs7481584 0.624 rs449164 chr11:3053454 C/T cg25174290 chr11:3078921 CARS -0.41 -5.65 -0.3 3.48e-8 Calcium levels; CRC cis rs7799006 0.606 rs12535174 chr7:2310974 C/T cg08027265 chr7:2291960 NA -0.47 -7.91 -0.4 3.92e-14 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs7615952 0.599 rs6779141 chr3:125709995 A/T cg04553112 chr3:125709451 NA -0.51 -5.85 -0.31 1.17e-8 Blood pressure (smoking interaction); CRC cis rs7937682 0.824 rs11213962 chr11:111506027 G/A cg09085632 chr11:111637200 PPP2R1B -0.99 -19.28 -0.73 5.84e-56 Primary sclerosing cholangitis; CRC cis rs875971 0.825 rs10281499 chr7:66048966 A/G cg18252515 chr7:66147081 NA 0.44 6.21 0.32 1.64e-9 Aortic root size; CRC cis rs67311347 1.000 rs11129876 chr3:40401636 C/T cg09455208 chr3:40491958 NA -0.42 -8.49 -0.42 6.95e-16 Renal cell carcinoma; CRC cis rs801193 0.569 rs2659908 chr7:66160822 G/A cg12463550 chr7:65579703 CRCP 0.46 6.2 0.32 1.69e-9 Aortic root size; CRC trans rs7395662 0.819 rs12269855 chr11:48778652 C/G cg21153622 chr11:89784906 NA -0.48 -7.7 -0.39 1.66e-13 HDL cholesterol; CRC cis rs863345 0.604 rs11265010 chr1:158498853 G/A cg12129480 chr1:158549410 OR10X1 -0.3 -6.27 -0.33 1.12e-9 Pneumococcal bacteremia; CRC cis rs8044868 0.548 rs3909541 chr16:72201119 C/T cg23815491 chr16:72088622 HP -0.43 -6.49 -0.34 3.13e-10 Body mass index (change over time) in cancer or chronic obstructive pulmonary disease;Body mass index (change over time) in cancer; CRC cis rs9443645 0.527 rs10943596 chr6:79575292 C/T cg05283184 chr6:79620031 NA -0.45 -6.57 -0.34 2e-10 Intelligence (multi-trait analysis); CRC cis rs3768617 0.510 rs2224933 chr1:183095765 A/G ch.1.3577855R chr1:183094577 LAMC1 0.89 15.86 0.66 1.84e-42 Fuchs's corneal dystrophy; CRC cis rs17234274 0.644 rs1482746 chr11:23225003 T/C cg05245346 chr11:23248277 NA 0.35 5.72 0.3 2.38e-8 Cancer; CRC trans rs116095464 0.558 rs10057674 chr5:266813 C/T cg00938859 chr5:1591904 SDHAP3 0.74 7.95 0.4 3.03e-14 Breast cancer; CRC cis rs9611565 0.694 rs202664 chr22:41813886 C/T cg03806693 chr22:41940476 POLR3H 1.03 12.92 0.58 3.76e-31 Vitiligo; CRC cis rs12541635 0.934 rs10955407 chr8:107020648 G/A cg10147462 chr8:107024639 NA 0.42 6.99 0.36 1.57e-11 Age of smoking initiation; CRC cis rs2070677 0.935 rs4384343 chr10:135422545 G/C cg20169779 chr10:135381914 SYCE1 -0.96 -15.45 -0.65 7.15e-41 Gout; CRC cis rs270601 0.770 rs932019 chr5:131599370 T/C cg18758796 chr5:131593413 PDLIM4 0.49 8.91 0.44 3.52e-17 Acylcarnitine levels; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg09525523 chr12:16064153 DERA 0.44 6.05 0.32 4.04e-9 Anxiety disorder; CRC cis rs11969893 0.737 rs1856131 chr6:101407104 C/G cg12253828 chr6:101329408 ASCC3 0.79 6.47 0.34 3.55e-10 Economic and political preferences (immigration/crime); CRC cis rs736408 0.507 rs6445531 chr3:52717282 T/C cg15147215 chr3:52552868 STAB1 -0.65 -11.12 -0.52 1.31e-24 Bipolar disorder; CRC cis rs2842992 0.830 rs1998365 chr6:160179535 A/T cg16489826 chr6:160211363 TCP1;MRPL18 0.49 6.24 0.33 1.38e-9 Age-related macular degeneration (geographic atrophy); CRC cis rs9611565 0.840 rs3788584 chr22:41779073 T/A cg06481639 chr22:41940642 POLR3H -0.5 -5.66 -0.3 3.31e-8 Vitiligo; CRC cis rs9916302 0.706 rs8182252 chr17:37727950 T/C cg20243544 chr17:37824526 PNMT -0.44 -5.61 -0.3 4.2e-8 Glomerular filtration rate (creatinine); CRC cis rs736801 0.569 rs11748193 chr5:131725329 A/T cg00255919 chr5:131827918 IRF1 -0.34 -5.81 -0.3 1.51e-8 Breast cancer;Mosquito bite size; CRC cis rs7843479 0.601 rs1058486 chr8:21862551 A/G cg16476235 chr8:21771668 DOK2 0.41 7.05 0.36 1.07e-11 Mean corpuscular volume; CRC cis rs7493 0.950 rs12704794 chr7:95036133 A/T cg01874867 chr7:94954059 PON1 -0.49 -6.36 -0.33 6.6e-10 Yu-Zhi constitution type in type 2 diabetes; CRC trans rs2727020 0.729 rs10742932 chr11:49173234 T/C cg21153622 chr11:89784906 NA -0.44 -7.15 -0.37 5.73e-12 Coronary artery disease; CRC cis rs6570726 0.935 rs429306 chr6:145827016 T/C cg23711669 chr6:146136114 FBXO30 0.68 12.16 0.56 2.33e-28 Lobe attachment (rater-scored or self-reported); CRC cis rs11758351 0.517 rs79958315 chr6:26221826 C/T cg22723502 chr6:26240528 HIST1H4F -0.37 -6.05 -0.32 3.93e-9 Gout;Renal underexcretion gout; CRC cis rs1005277 0.579 rs1780133 chr10:38499509 T/C cg17219203 chr10:38645113 HSD17B7P2 -0.42 -5.94 -0.31 7.23e-9 Extrinsic epigenetic age acceleration; CRC cis rs2530545 0.651 rs10261506 chr7:34662042 T/C cg14401837 chr7:34697493 NPSR1 0.42 6.27 0.33 1.14e-9 IgG glycosylation; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg09525994 chr12:48512905 PFKM 0.43 6.67 0.35 1.06e-10 Liver disease severity in Alagille syndrome; CRC cis rs6964587 0.839 rs17731846 chr7:91440342 A/G cg17063962 chr7:91808500 NA 0.67 10.34 0.5 6.87e-22 Breast cancer; CRC cis rs653465 0.621 rs11719250 chr3:27174261 G/T cg02860705 chr3:27208620 NA -0.38 -5.91 -0.31 8.66e-9 Breast cancer (early onset); CRC cis rs12529935 0.609 rs12526057 chr6:90895994 C/G cg06866423 chr6:90926672 BACH2 0.71 6.54 0.34 2.3e-10 Systemic lupus erythematosus; CRC cis rs6495122 0.501 rs12101482 chr15:75344784 A/T cg14664628 chr15:75095509 CSK 0.47 6.97 0.36 1.77e-11 Caffeine consumption;Diastolic blood pressure;Coffee consumption; CRC cis rs6479527 0.625 rs1933667 chr9:96744109 G/C cg14459158 chr9:96720562 NA 0.45 8.28 0.42 3.08e-15 Esophageal adenocarcinoma; CRC cis rs589448 0.902 rs2603089 chr12:69776800 C/T cg14784868 chr12:69753453 YEATS4 -0.9 -17.43 -0.69 1.19e-48 Cerebrospinal fluid biomarker levels; CRC cis rs68170813 0.559 rs1121312 chr7:106927820 C/T cg02696742 chr7:106810147 HBP1 -0.61 -6.71 -0.35 8.63e-11 Coronary artery disease; CRC cis rs9733 0.596 rs11586422 chr1:150679358 C/T cg10589385 chr1:150898437 SETDB1 0.28 5.96 0.31 6.66e-9 Tonsillectomy; CRC trans rs6076960 0.598 rs3905168 chr20:6226752 C/T cg21095983 chr6:86352623 SYNCRIP 0.56 8.07 0.41 1.35e-14 Smooth-surface caries; CRC cis rs597539 0.652 rs584108 chr11:68630282 A/T cg04772025 chr11:68637568 NA -0.5 -7.79 -0.39 8.56e-14 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs10489202 0.632 rs275137 chr1:168051266 A/C cg24449463 chr1:168025552 DCAF6 0.63 9.8 0.48 4.66e-20 Schizophrenia; CRC cis rs2303759 0.709 rs7256363 chr19:49827804 C/T cg24324837 chr19:49891574 CCDC155 0.53 7.0 0.36 1.45e-11 Multiple sclerosis; CRC cis rs854765 0.927 rs12943914 chr17:17980671 A/G cg04398451 chr17:18023971 MYO15A -0.58 -9.72 -0.47 8.63e-20 Total body bone mineral density; CRC cis rs7615952 0.641 rs12491577 chr3:125731131 C/T cg02807482 chr3:125708958 NA -0.45 -5.82 -0.31 1.37e-8 Blood pressure (smoking interaction); CRC cis rs62229266 0.804 rs998383 chr21:37445739 C/G cg12218747 chr21:37451666 NA -0.43 -7.32 -0.37 1.94e-12 Mitral valve prolapse; CRC cis rs2243480 1.000 rs4548056 chr7:65298873 A/G cg12463550 chr7:65579703 CRCP 0.65 5.98 0.31 5.9e-9 Diabetic kidney disease; CRC cis rs9611565 0.512 rs5758465 chr22:42175314 T/C cg03806693 chr22:41940476 POLR3H 1.09 13.47 0.6 3.05e-33 Vitiligo; CRC cis rs11608355 0.573 rs7970666 chr12:109793495 T/G cg19025524 chr12:109796872 NA -0.62 -10.12 -0.49 3.93e-21 Neuroticism; CRC cis rs11098499 0.865 rs3956464 chr4:120256764 T/C cg24375607 chr4:120327624 NA 0.47 7.45 0.38 8.16e-13 Corneal astigmatism; CRC cis rs736801 0.964 rs17622656 chr5:131820997 A/G cg00255919 chr5:131827918 IRF1 0.34 5.67 0.3 3.19e-8 Breast cancer;Mosquito bite size; CRC trans rs11615274 0.527 rs10879550 chr12:73502964 C/T cg06707406 chr2:50570407 NRXN1 0.41 5.96 0.31 6.47e-9 Body mass index and cholesterol (psychopharmacological treatment); CRC cis rs910316 1.000 rs2268617 chr14:75608728 G/A cg08847533 chr14:75593920 NEK9 0.92 17.33 0.69 2.9e-48 Height; CRC cis rs9914988 0.943 rs4795457 chr17:27087929 C/T cg16670446 chr17:27188758 MIR451;MIR144 0.55 8.4 0.42 1.33e-15 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs7591163 1.000 rs4487084 chr2:228713179 G/A cg14329157 chr2:228736135 WDR69 -0.47 -6.53 -0.34 2.48e-10 Blood pressure; CRC cis rs12477438 0.798 rs6732579 chr2:99560239 A/T cg26064155 chr2:99771622 LIPT1;TSGA10 -0.72 -10.04 -0.48 7.33e-21 Chronic sinus infection; CRC cis rs10924970 0.967 rs6688441 chr1:235489184 A/C cg26050004 chr1:235667680 B3GALNT2 -0.4 -6.1 -0.32 2.97e-9 Asthma; CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg11407514 chr10:99094219 FRAT2 -0.53 -6.41 -0.33 4.93e-10 Diisocyanate-induced asthma; CRC cis rs6088813 1.000 rs6088823 chr20:33994265 G/T cg14752227 chr20:34000481 UQCC -0.37 -5.72 -0.3 2.33e-8 Height; CRC cis rs2841277 0.771 rs2819469 chr14:105394859 G/A cg15352829 chr14:105391018 PLD4 0.5 10.68 0.51 4.86e-23 Rheumatoid arthritis; CRC cis rs9611565 0.921 rs3927 chr22:41722864 A/G cg03806693 chr22:41940476 POLR3H -0.83 -10.84 -0.51 1.29e-23 Vitiligo; CRC cis rs2742417 0.603 rs2742457 chr3:45767487 G/A cg10512202 chr3:45649293 LIMD1 0.4 5.82 0.31 1.4e-8 Response to anti-depressant treatment in major depressive disorder; CRC trans rs7604735 0.635 rs1830319 chr2:145821597 C/T cg26010734 chr19:15344046 EPHX3 -0.34 -6.29 -0.33 1.02e-9 Coronary artery disease; CRC cis rs9372498 0.536 rs72952733 chr6:118834452 A/G cg07617317 chr6:118971624 C6orf204 0.46 5.64 0.3 3.6e-8 Diastolic blood pressure; CRC cis rs1707322 0.721 rs11211163 chr1:46153548 C/T cg03146154 chr1:46216737 IPP 0.67 9.82 0.48 3.95e-20 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs6429082 0.764 rs2481095 chr1:235695756 T/C cg26050004 chr1:235667680 B3GALNT2 -0.54 -7.16 -0.37 5.3e-12 Adiposity; CRC cis rs951366 0.617 rs823080 chr1:205789282 G/A cg24503407 chr1:205819492 PM20D1 1.02 18.51 0.71 6.31e-53 Menarche (age at onset); CRC cis rs1153858 1.000 rs10519022 chr15:45663684 C/T cg10760299 chr15:45669010 GATM -0.51 -8.14 -0.41 8.3e-15 Homoarginine levels; CRC cis rs9311474 0.508 rs12637627 chr3:52619962 G/T cg11645453 chr3:52864694 ITIH4 0.36 6.48 0.34 3.42e-10 Electroencephalogram traits; CRC cis rs7208859 0.623 rs9896603 chr17:29078512 C/G cg13385521 chr17:29058706 SUZ12P 0.72 8.24 0.41 4.19e-15 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs68170813 0.559 rs76646886 chr7:107034328 T/C cg02696742 chr7:106810147 HBP1 -0.58 -6.07 -0.32 3.44e-9 Coronary artery disease; CRC cis rs7772486 0.597 rs9285508 chr6:146262697 G/T cg05347473 chr6:146136440 FBXO30 -0.46 -6.03 -0.32 4.47e-9 Lobe attachment (rater-scored or self-reported); CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg05889321 chr10:97416837 ALDH18A1 -0.51 -6.46 -0.34 3.84e-10 Diisocyanate-induced asthma; CRC cis rs7666738 0.830 rs13108422 chr4:99059267 G/A cg05340658 chr4:99064831 C4orf37 0.58 8.8 0.44 7.8e-17 Colonoscopy-negative controls vs population controls; CRC trans rs3942852 0.622 rs6485806 chr11:48102806 A/G cg03929089 chr4:120376271 NA 0.5 6.36 0.33 6.9e-10 Acute lymphoblastic leukemia (childhood); CRC cis rs3741151 1.000 rs79078097 chr11:73049771 G/A cg17517138 chr11:73019481 ARHGEF17 0.78 7.6 0.39 3.03e-13 GIP levels in response to oral glucose tolerance test (120 minutes); CRC cis rs5750830 0.649 rs5750818 chr22:39820885 A/G cg24399712 chr22:39784796 NA -0.49 -9.83 -0.48 3.7799999999999997e-20 Intelligence (multi-trait analysis); CRC cis rs6502050 0.835 rs8080625 chr17:80115447 G/A cg02741985 chr17:80059408 CCDC57 0.43 7.18 0.37 4.56e-12 Life satisfaction; CRC cis rs28386778 0.897 rs8066754 chr17:61816590 T/C cg25654072 chr17:61904446 PSMC5;FTSJ3 0.7 10.84 0.51 1.31e-23 Prudent dietary pattern; CRC cis rs9611519 0.929 rs11090039 chr22:41496800 G/A cg06634786 chr22:41940651 POLR3H -0.51 -6.33 -0.33 7.99e-10 Neuroticism; CRC cis rs6684514 0.961 rs10908501 chr1:156285513 G/T cg16558208 chr1:156270281 VHLL 0.58 8.92 0.44 3.2e-17 Mean corpuscular hemoglobin concentration;Glycated hemoglobin levels; CRC cis rs3820068 0.705 rs16851727 chr1:15857918 C/T cg27534772 chr1:16042836 PLEKHM2 0.43 7.24 0.37 3.13e-12 Systolic blood pressure; CRC cis rs7429990 0.930 rs71323371 chr3:47945817 A/T cg11946769 chr3:48343235 NME6 0.45 5.77 0.3 1.81e-8 Educational attainment (years of education); CRC cis rs3823572 0.542 rs2953636 chr7:133637904 A/G cg03336402 chr7:133662267 EXOC4 0.65 10.11 0.49 4.07e-21 Intelligence (multi-trait analysis); CRC cis rs853679 0.517 rs9368553 chr6:28082265 T/C cg03623178 chr6:28175578 NA 0.95 12.17 0.56 2.13e-28 Depression; CRC cis rs10857712 0.754 rs1052582 chr10:135233840 C/G cg01444801 chr10:135216882 MTG1 -0.55 -7.82 -0.4 7.4e-14 Systemic lupus erythematosus; CRC cis rs34779708 0.966 rs34630580 chr10:35449228 A/G cg03585969 chr10:35415529 CREM 0.63 8.39 0.42 1.42e-15 Inflammatory bowel disease;Crohn's disease; CRC cis rs1865760 0.566 rs7772312 chr6:26049616 G/C cg17691542 chr6:26056736 HIST1H1C 0.55 8.25 0.41 3.86e-15 Height; CRC cis rs7618915 0.547 rs2118540 chr3:52629386 T/C cg11645453 chr3:52864694 ITIH4 0.36 6.33 0.33 8.26e-10 Bipolar disorder; CRC cis rs9467603 0.925 rs6910549 chr6:25780811 A/G cg08501292 chr6:25962987 TRIM38 -0.62 -5.76 -0.3 1.93e-8 Intelligence (multi-trait analysis); CRC cis rs6570726 0.755 rs451699 chr6:145830594 C/G cg13319975 chr6:146136371 FBXO30 -0.44 -6.66 -0.34 1.13e-10 Lobe attachment (rater-scored or self-reported); CRC cis rs77861329 1.000 rs17051977 chr3:52182944 A/G cg08692210 chr3:52188851 WDR51A 0.79 7.63 0.39 2.52e-13 Macrophage inflammatory protein 1b levels; CRC cis rs798554 0.660 rs2644274 chr7:2854380 A/T cg19717773 chr7:2847554 GNA12 -0.47 -8.05 -0.41 1.56e-14 Height; CRC cis rs13082711 0.871 rs13061912 chr3:27495586 A/G cg02860705 chr3:27208620 NA 0.61 8.71 0.43 1.46e-16 Systolic blood pressure;Diastolic blood pressure;Blood pressure; CRC cis rs9368481 0.761 rs4713062 chr6:26948195 A/G cg05192639 chr6:26864778 GUSBL1 -0.34 -6.08 -0.32 3.29e-9 Autism spectrum disorder or schizophrenia; CRC cis rs796364 0.806 rs74938253 chr2:201008386 T/G cg25936922 chr2:200820526 C2orf60;C2orf47 -0.57 -5.67 -0.3 3.07e-8 Schizophrenia; CRC cis rs11997175 0.846 rs11776207 chr8:33765126 G/T ch.8.33884649F chr8:33765107 NA -0.45 -6.55 -0.34 2.25e-10 Body mass index; CRC cis rs9905704 0.881 rs2611774 chr17:56732304 G/A cg12560992 chr17:57184187 TRIM37 0.54 7.35 0.38 1.58e-12 Testicular germ cell tumor; CRC cis rs651907 0.557 rs7629753 chr3:101371922 C/T cg11279151 chr3:101281821 RG9MTD1 0.51 6.93 0.36 2.24e-11 Colorectal cancer; CRC cis rs4332037 0.539 rs868754 chr7:2033780 G/C cg13880726 chr7:1868755 MAD1L1 -0.5 -5.81 -0.31 1.44e-8 Bipolar disorder; CRC cis rs7618915 0.501 rs2159644 chr3:52774530 C/T cg18099408 chr3:52552593 STAB1 -0.47 -7.89 -0.4 4.59e-14 Bipolar disorder; CRC trans rs9329221 0.905 rs4433149 chr8:10249268 A/T cg16141378 chr3:129829833 LOC729375 0.42 6.54 0.34 2.38e-10 Neuroticism; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg18163118 chr11:67250585 AIP -0.4 -6.02 -0.31 4.77e-9 Myopia (pathological); CRC cis rs10751667 0.666 rs6597962 chr11:976351 C/T ch.11.42038R chr11:967971 AP2A2 0.6 10.3 0.49 9.15e-22 Alzheimer's disease (late onset); CRC cis rs6496667 1.000 rs58436485 chr15:90900633 G/A cg04176472 chr15:90893244 GABARAPL3 0.61 8.26 0.41 3.64e-15 Rheumatoid arthritis; CRC cis rs932287 0.540 rs4910442 chr11:9044337 T/C cg14711859 chr11:8959438 ASCL3 -0.37 -5.72 -0.3 2.35e-8 Colonoscopy-negative controls vs population controls; CRC cis rs4563143 0.704 rs16961809 chr19:29226299 C/T cg12667521 chr19:29218732 NA 0.51 8.07 0.41 1.29e-14 Methadone dose in opioid dependence; CRC cis rs6969780 1.000 rs6948297 chr7:27149404 A/G cg26364809 chr7:27145159 NA -0.78 -7.53 -0.38 4.81e-13 Diastolic blood pressure;Blood pressure traits (multi-trait analysis);Systolic blood pressure;Hypertension; CRC trans rs2303319 0.504 rs62189003 chr2:162548104 T/A cg12500891 chr11:57225987 NA -0.67 -6.03 -0.32 4.51e-9 Cognitive function; CRC cis rs6762 0.748 rs7936838 chr11:839093 G/C cg16425592 chr11:842748 TSPAN4;POLR2L -0.55 -8.2 -0.41 5.53e-15 Mean platelet volume; CRC cis rs6445967 1.000 rs12688 chr3:58305079 T/C cg23715586 chr3:58305044 RPP14 0.34 5.75 0.3 2.03e-8 Platelet count; CRC cis rs7811142 1.000 rs7811142 chr7:100065443 A/T cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.63 8.24 0.41 4.27e-15 Platelet count; CRC cis rs6461049 0.800 rs3800909 chr7:2159594 C/G cg02951883 chr7:2050386 MAD1L1 -0.56 -9.06 -0.45 1.21e-17 Schizophrenia; CRC cis rs4880487 0.505 rs4880778 chr10:1205810 C/G cg10055817 chr10:1229050 ADARB2 0.4 6.66 0.34 1.14e-10 Migraine; CRC cis rs9527 0.590 rs10883843 chr10:104947493 C/G cg15744005 chr10:104629667 AS3MT -0.3 -5.82 -0.31 1.37e-8 Arsenic metabolism; CRC cis rs7811142 0.943 rs111493473 chr7:100049742 A/G cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.63 8.51 0.42 6.27e-16 Platelet count; CRC cis rs4689592 0.546 rs10937784 chr4:7060935 G/C cg26116260 chr4:7069785 GRPEL1 0.94 14.66 0.63 8.11e-38 Monocyte percentage of white cells; CRC cis rs951366 0.617 rs823080 chr1:205789282 G/A cg23034840 chr1:205782522 SLC41A1 0.57 8.15 0.41 7.94e-15 Menarche (age at onset); CRC cis rs4665809 0.590 rs7579504 chr2:26439995 T/C cg04944784 chr2:26401820 FAM59B -0.83 -10.74 -0.51 2.96e-23 Gut microbiome composition (summer); CRC cis rs9287719 0.967 rs7570118 chr2:10718007 G/T cg00105475 chr2:10696890 NA 0.45 7.26 0.37 2.84e-12 Prostate cancer; CRC cis rs1670533 1.000 rs10902752 chr4:1056199 C/T cg27284194 chr4:1044797 NA 0.5 6.2 0.32 1.66e-9 Recombination rate (females); CRC cis rs2072499 0.750 rs57056972 chr1:156159064 C/A cg25208724 chr1:156163844 SLC25A44 1.01 16.24 0.67 5.94e-44 Testicular germ cell tumor; CRC cis rs9814567 0.896 rs7642266 chr3:134346025 G/A cg06109529 chr3:134205091 CEP63;ANAPC13 -0.67 -9.59 -0.47 2.35e-19 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs6743226 0.870 rs12624197 chr2:242254737 G/C cg10021735 chr2:242295487 FARP2 0.47 6.9 0.36 2.66e-11 Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI in non-smokers; CRC cis rs916888 0.773 rs199535 chr17:44822662 A/G cg15921436 chr17:44337874 NA 0.8 8.86 0.44 5.11e-17 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs9733 0.519 rs10788792 chr1:150638572 T/G cg10589385 chr1:150898437 SETDB1 0.29 6.2 0.32 1.7e-9 Tonsillectomy; CRC trans rs2014572 0.967 rs8100154 chr19:57765432 A/G cg02674126 chr19:40336878 FBL 0.41 6.61 0.34 1.56e-10 Hyperactive-impulsive symptoms; CRC cis rs6964587 0.773 rs10488514 chr7:91951842 C/A cg17063962 chr7:91808500 NA 0.73 10.82 0.51 1.5e-23 Breast cancer; CRC cis rs561341 1.000 rs548957 chr17:30302411 G/A cg23018236 chr17:30244563 NA -0.67 -8.02 -0.4 1.83e-14 Hip circumference adjusted for BMI; CRC cis rs875971 0.895 rs1833495 chr7:65921595 T/C cg18912574 chr7:65842487 NCRNA00174 0.36 6.1 0.32 2.97e-9 Aortic root size; CRC cis rs2708240 0.666 rs2710117 chr7:147601772 T/A cg02373104 chr7:147601429 MIR548F3;CNTNAP2 -0.44 -6.42 -0.33 4.87e-10 QT interval (drug interaction); CRC cis rs2115630 0.967 rs10438428 chr15:85330745 C/T cg11189052 chr15:85197271 WDR73 -0.6 -9.86 -0.48 3e-20 P wave terminal force; CRC cis rs7552404 1.000 rs12123977 chr1:76209754 A/G cg10523679 chr1:76189770 ACADM -0.83 -11.41 -0.53 1.28e-25 Blood metabolite levels;Acylcarnitine levels; CRC cis rs847577 0.630 rs6967926 chr7:97715088 C/T cg24562669 chr7:97807699 LMTK2 0.76 17.11 0.69 2.17e-47 Breast cancer; CRC cis rs992157 1.000 rs2168704 chr2:219142492 G/A cg00012203 chr2:219082015 ARPC2 0.51 8.37 0.42 1.62e-15 Colorectal cancer; CRC cis rs7493 0.755 rs17166861 chr7:95020602 G/C cg04155289 chr7:94953770 PON1 -0.59 -7.29 -0.37 2.26e-12 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs748404 0.578 rs512628 chr15:43618734 A/G cg15269541 chr15:43626905 ADAL -0.39 -6.0 -0.31 5.1e-9 Lung cancer; CRC cis rs10504229 0.639 rs2318146 chr8:58114873 T/G cg02725872 chr8:58115012 NA -0.65 -11.61 -0.54 2.34e-26 Developmental language disorder (linguistic errors); CRC cis rs13082711 0.555 rs73149363 chr3:27265394 C/A cg02860705 chr3:27208620 NA 0.72 9.31 0.46 1.83e-18 Systolic blood pressure;Diastolic blood pressure;Blood pressure; CRC cis rs738322 0.718 rs2899297 chr22:38594668 A/G cg25457927 chr22:38595422 NA -0.53 -11.96 -0.55 1.24e-27 Cutaneous nevi; CRC cis rs7113874 0.569 rs1446463 chr11:8566329 G/A cg02811074 chr11:8615871 STK33 -0.36 -6.14 -0.32 2.44e-9 Body mass index in physically active individuals;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs3091242 0.902 rs36003018 chr1:25784318 A/G cg23205692 chr1:25664452 TMEM50A -0.4 -5.67 -0.3 3.13e-8 Erythrocyte sedimentation rate; CRC cis rs561341 1.000 rs554078 chr17:30330109 A/C cg23018236 chr17:30244563 NA -0.67 -7.98 -0.4 2.51e-14 Hip circumference adjusted for BMI; CRC cis rs9916302 0.904 rs650106 chr17:37451559 A/G cg15445000 chr17:37608096 MED1 -0.42 -9.22 -0.45 3.61e-18 Glomerular filtration rate (creatinine); CRC cis rs853679 0.517 rs9368550 chr6:28051803 T/A cg03623178 chr6:28175578 NA 0.94 12.29 0.56 7.67e-29 Depression; CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg05445914 chr16:30134068 MAPK3 0.38 6.38 0.33 5.91e-10 Obesity-related traits; CRC cis rs6461049 0.765 rs3800908 chr7:2159437 C/T cg14004847 chr7:1930337 MAD1L1 -0.43 -6.2 -0.32 1.65e-9 Schizophrenia; CRC cis rs9467711 0.659 rs13220261 chr6:26499185 C/T cg16898833 chr6:26189333 HIST1H4D 1.14 8.46 0.42 8.89e-16 Autism spectrum disorder or schizophrenia; CRC cis rs9325144 0.560 rs2387924 chr12:38662883 A/G cg26384229 chr12:38710491 ALG10B -0.49 -7.26 -0.37 2.89e-12 Morning vs. evening chronotype; CRC cis rs4925325 0.741 rs6142886 chr20:60511190 A/G cg13770153 chr20:60521292 NA 0.92 17.34 0.69 2.55e-48 Obesity-related traits; CRC cis rs7493 0.901 rs17879517 chr7:95030646 T/C cg21856205 chr7:94953877 PON1 -0.48 -6.23 -0.32 1.46e-9 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs2033908 0.620 rs1992334 chr11:12851645 C/T cg25843174 chr11:12811716 TEAD1 -0.4 -7.12 -0.37 7.03e-12 Sitting height ratio; CRC trans rs9341835 0.618 rs1779747 chr6:64141100 C/T cg13657004 chr13:50234944 EBPL 0.38 6.63 0.34 1.39e-10 Schizophrenia; CRC cis rs9611565 0.659 rs17367716 chr22:41913844 A/G cg17554472 chr22:41940697 POLR3H -0.55 -5.82 -0.31 1.4e-8 Vitiligo; CRC cis rs13064411 0.518 rs6438160 chr3:113217591 A/C cg18753928 chr3:113234510 CCDC52 -0.48 -7.67 -0.39 2.01e-13 Response to simvastatin treatment (PCSK9 protein level change); CRC cis rs3785574 0.745 rs2854162 chr17:61975610 T/C cg22520471 chr17:61851767 DDX42;CCDC47 -0.48 -6.38 -0.33 5.87e-10 Height; CRC cis rs11252926 0.598 rs4881256 chr10:453831 T/A cg18196295 chr10:418757 DIP2C 0.48 7.47 0.38 7.42e-13 Psychosis in Alzheimer's disease; CRC cis rs2204008 0.775 rs12099736 chr12:38344111 C/G cg26384229 chr12:38710491 ALG10B 0.69 9.71 0.47 9.43e-20 Bladder cancer; CRC cis rs796364 0.806 rs203767 chr2:200902411 G/A cg25936922 chr2:200820526 C2orf60;C2orf47 -0.7 -6.57 -0.34 2.02e-10 Schizophrenia; CRC trans rs1814175 0.669 rs12364577 chr11:49707361 A/C cg03929089 chr4:120376271 NA -0.74 -12.26 -0.56 1.02e-28 Height; CRC cis rs883565 0.568 rs6599004 chr3:39095678 C/T cg01426195 chr3:39028469 NA -0.54 -8.77 -0.44 9.85e-17 Handedness; CRC cis rs7412746 0.611 rs1889741 chr1:150869045 T/C cg10589385 chr1:150898437 SETDB1 0.28 6.07 0.32 3.43e-9 Melanoma; CRC cis rs9811920 0.638 rs1688782 chr3:99630527 C/G cg07805332 chr3:99536008 MIR548G;C3orf26 0.52 8.05 0.41 1.52e-14 Axial length; CRC cis rs62458065 1.000 rs1450868 chr7:32463666 G/A cg20159608 chr7:32802032 NA -0.49 -6.07 -0.32 3.53e-9 Metabolite levels (HVA/MHPG ratio); CRC cis rs1799949 1.000 rs1545764 chr17:41424565 G/A cg01879757 chr17:41196368 BRCA1 -0.41 -6.0 -0.31 5.15e-9 Menopause (age at onset); CRC cis rs1799949 1.000 rs12950607 chr17:41299928 G/C cg05368731 chr17:41323189 NBR1 0.69 10.5 0.5 1.94e-22 Menopause (age at onset); CRC cis rs4664308 1.000 rs17831161 chr2:160909360 A/G cg03641300 chr2:160917029 PLA2R1 -0.75 -12.47 -0.57 1.78e-29 Idiopathic membranous nephropathy; CRC cis rs9814567 0.806 rs6799543 chr3:134216139 G/T cg06109529 chr3:134205091 CEP63;ANAPC13 -0.81 -12.08 -0.55 4.67e-28 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC trans rs797680 0.856 rs6541404 chr1:93743434 A/T cg09807536 chr1:203457686 PRELP 0.43 6.48 0.34 3.36e-10 Eosinophil percentage of white cells;Sum eosinophil basophil counts; CRC cis rs11971779 0.715 rs10265 chr7:139026152 T/G cg07862535 chr7:139043722 LUC7L2 0.54 7.03 0.36 1.18e-11 Diisocyanate-induced asthma; CRC cis rs2836974 0.627 rs9981301 chr21:40686078 G/C cg11644478 chr21:40555479 PSMG1 -0.63 -9.69 -0.47 1.11e-19 Cognitive function; CRC trans rs4140564 0.730 rs7554410 chr1:186767992 T/G cg01619416 chr16:1110991 NA -0.44 -6.02 -0.31 4.59e-9 Knee osteoarthritis; CRC cis rs4843747 0.671 rs74729706 chr16:88104159 C/T cg17633681 chr16:88106987 BANP 0.88 16.15 0.66 1.35e-43 Menopause (age at onset); CRC cis rs7212590 0.748 rs8073489 chr17:57861794 A/C cg10252138 chr17:58120427 NA -0.55 -5.87 -0.31 1.09e-8 Granulocyte percentage of myeloid white cells;Monocyte count;Monocyte percentage of white cells; CRC cis rs4253772 0.513 rs9306512 chr22:46716603 T/C cg09491104 chr22:46646882 C22orf40 -0.46 -7.0 -0.36 1.41e-11 LDL cholesterol;Cholesterol, total; CRC cis rs7208859 0.573 rs8064686 chr17:29134839 C/T cg01831904 chr17:28903510 LRRC37B2 -0.62 -6.41 -0.33 5.13e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs8016982 0.651 rs9806027 chr14:81668707 G/C cg01989461 chr14:81687754 GTF2A1 0.49 7.75 0.39 1.12e-13 Schizophrenia; CRC cis rs6504340 0.600 rs2325946 chr17:46584631 G/C cg04904318 chr17:46607828 HOXB1 0.45 5.95 0.31 6.86e-9 Primary tooth development (number of teeth); CRC cis rs12983728 1.000 rs12983728 chr19:58671267 G/A cg12792011 chr19:58661915 ZNF329 0.72 7.86 0.4 5.5e-14 Cholesterol, total; CRC cis rs9381040 0.610 rs2057002 chr6:41022962 G/T cg25110423 chr6:41068646 NFYA;LOC221442 -0.38 -5.93 -0.31 7.72e-9 Alzheimer's disease (late onset); CRC cis rs6691722 0.503 rs3765432 chr1:24706461 A/G cg18323236 chr1:24743029 NIPAL3 0.39 5.72 0.3 2.37e-8 Response to interferon beta in multiple sclerosis; CRC cis rs6570726 0.935 rs384806 chr6:145814889 C/G cg23711669 chr6:146136114 FBXO30 0.68 12.05 0.55 6.18e-28 Lobe attachment (rater-scored or self-reported); CRC cis rs11997175 0.574 rs4733453 chr8:33650745 A/G cg04338863 chr8:33670619 NA 0.41 6.92 0.36 2.37e-11 Body mass index; CRC cis rs17021463 0.902 rs10516950 chr4:95254730 C/T cg11021082 chr4:95130006 SMARCAD1 0.48 7.38 0.38 1.32e-12 Testicular germ cell tumor; CRC trans rs2727020 0.729 rs685789 chr11:49241228 G/A cg21153622 chr11:89784906 NA 0.39 6.15 0.32 2.2e-9 Coronary artery disease; CRC cis rs1552244 0.572 rs67439440 chr3:10169503 C/T cg02579736 chr3:10068473 FANCD2;CIDECP 1.01 11.62 0.54 2.28e-26 Alzheimer's disease; CRC cis rs1862618 0.671 rs2591966 chr5:56233688 T/G cg18230493 chr5:56204884 C5orf35 0.55 8.26 0.41 3.66e-15 Initial pursuit acceleration; CRC cis rs2239547 0.657 rs12496077 chr3:52886241 G/A cg15147215 chr3:52552868 STAB1 -0.41 -5.78 -0.3 1.77e-8 Schizophrenia; CRC cis rs909002 0.789 rs56074668 chr1:32123801 T/C cg01639898 chr1:32083012 HCRTR1 0.32 6.67 0.35 1.09e-10 Intelligence (multi-trait analysis); CRC cis rs9399135 0.967 rs4896123 chr6:135295410 T/G cg24558204 chr6:135376177 HBS1L 0.47 7.21 0.37 3.8e-12 Red blood cell count; CRC cis rs992157 0.798 rs10193383 chr2:219157692 C/T cg04880052 chr2:219191631 PNKD 0.42 6.76 0.35 6.16e-11 Colorectal cancer; CRC trans rs2235573 0.527 rs139885 chr22:38371039 C/T cg19894588 chr14:64061835 NA 0.5 7.05 0.36 1.06e-11 Glioblastoma;Glioma; CRC cis rs9372498 0.536 rs9489457 chr6:118920285 C/T cg18833306 chr6:118973337 C6orf204 0.44 5.71 0.3 2.54e-8 Diastolic blood pressure; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg10922530 chr12:124457083 CCDC92;ZNF664 0.4 7.51 0.38 5.44e-13 Liver disease severity in Alagille syndrome; CRC cis rs3806843 0.706 rs1089305 chr5:140066306 T/C cg19875535 chr5:140030758 IK -0.63 -10.64 -0.51 6.55e-23 Depressive symptoms (multi-trait analysis); CRC cis rs28386778 0.830 rs2665798 chr17:61921397 C/T cg25654072 chr17:61904446 PSMC5;FTSJ3 0.72 11.16 0.52 9.37e-25 Prudent dietary pattern; CRC cis rs2067615 0.524 rs4275715 chr12:107062246 C/T cg15890332 chr12:107067104 RFX4 0.32 5.64 0.3 3.65e-8 Heart rate; CRC cis rs365302 1.000 rs294923 chr6:159620925 G/A cg14500486 chr6:159655392 FNDC1 0.51 7.53 0.38 4.94e-13 Coronary heart disease; CRC cis rs10504229 0.775 rs17804840 chr8:58157045 C/T cg02290350 chr8:58132656 NA -0.51 -6.39 -0.33 5.68e-10 Developmental language disorder (linguistic errors); CRC cis rs4658101 0.700 rs12048543 chr1:92050356 C/T cg24006770 chr1:92056542 NA 0.46 6.91 0.36 2.56e-11 Optic disc area;Vertical cup-disc ratio; CRC cis rs35110281 0.517 rs11089020 chr21:44939991 C/T cg04455712 chr21:45112962 RRP1B 0.39 7.04 0.36 1.12e-11 Mean corpuscular volume; CRC cis rs713587 0.520 rs493090 chr2:25303772 G/A cg22495460 chr2:25135724 ADCY3 0.44 6.61 0.34 1.54e-10 Body mass index in non-asthmatics; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg10556830 chr5:68462986 CCNB1 0.45 6.44 0.33 4.35e-10 Response to antipsychotic treatment; CRC cis rs9858542 1.000 rs11130213 chr3:49712297 C/T cg07274523 chr3:49395745 GPX1 0.47 5.98 0.31 5.79e-9 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs2742417 0.603 rs2742449 chr3:45764544 T/C cg04837898 chr3:45731254 SACM1L -0.48 -7.69 -0.39 1.74e-13 Response to anti-depressant treatment in major depressive disorder; CRC cis rs7727544 0.618 rs2631367 chr5:131705458 C/G cg02033258 chr5:131593261 PDLIM4 -0.31 -5.75 -0.3 2.08e-8 Blood metabolite levels; CRC cis rs589448 0.902 rs315124 chr12:69771727 G/A cg22834771 chr12:69754056 YEATS4 -0.55 -8.66 -0.43 2.12e-16 Cerebrospinal fluid biomarker levels; CRC cis rs11608355 0.515 rs7311488 chr12:109930905 C/G cg05360138 chr12:110035743 NA -0.78 -8.76 -0.44 1.02e-16 Neuroticism; CRC cis rs7615952 0.599 rs12486459 chr3:125741465 T/G cg15145296 chr3:125709740 NA -0.57 -6.5 -0.34 2.98e-10 Blood pressure (smoking interaction); CRC cis rs28655083 0.843 rs1502433 chr16:77087101 C/T cg01753188 chr16:77233325 SYCE1L;MON1B 0.54 7.76 0.39 1.09e-13 Lobe attachment (rater-scored or self-reported); CRC cis rs28386778 0.933 rs2665801 chr17:61952100 C/T cg25654072 chr17:61904446 PSMC5;FTSJ3 0.72 11.13 0.52 1.23e-24 Prudent dietary pattern; CRC cis rs7178572 0.633 rs7162637 chr15:77843365 A/G cg22256960 chr15:77711686 NA -0.63 -8.87 -0.44 4.77e-17 Type 2 diabetes; CRC cis rs9427116 0.502 rs9427104 chr1:154589232 C/T cg24304309 chr1:154577895 ADAR 0.34 5.69 0.3 2.87e-8 Blood protein levels; CRC cis rs2976388 0.590 rs10110970 chr8:143820410 G/C cg20041105 chr8:143859282 LYNX1 -0.41 -6.78 -0.35 5.61e-11 Urinary tract infection frequency; CRC cis rs17401966 0.931 rs12131441 chr1:10428952 G/A cg19773385 chr1:10388646 KIF1B -0.68 -10.98 -0.52 4.16e-24 Hepatocellular carcinoma; CRC cis rs6495122 0.644 rs11630087 chr15:75261673 G/T cg18612461 chr15:75251733 NA 0.48 7.26 0.37 2.88e-12 Caffeine consumption;Diastolic blood pressure;Coffee consumption; CRC cis rs10883723 0.737 rs7074444 chr10:104249922 A/G cg11453585 chr10:104263688 ACTR1A;SUFU 0.91 17.11 0.69 2.18e-47 Allergic disease (asthma, hay fever or eczema); CRC trans rs7395662 0.591 rs4882093 chr11:48530820 G/A cg15704280 chr7:45808275 SEPT13 -0.48 -6.83 -0.35 4.14e-11 HDL cholesterol; CRC trans rs951252 0.504 rs11734405 chr4:146081096 C/T cg09741240 chr6:3000097 NQO2 0.46 5.96 0.31 6.51e-9 Hip circumference; CRC cis rs13315871 1.000 rs71311855 chr3:58320507 A/G cg20936604 chr3:58311152 NA -0.76 -7.27 -0.37 2.69e-12 Cholesterol, total; CRC cis rs10504229 0.683 rs10504225 chr8:58145121 A/T cg21724239 chr8:58056113 NA 0.48 6.62 0.34 1.45e-10 Developmental language disorder (linguistic errors); CRC cis rs2625529 0.556 rs55679065 chr15:72433395 C/T cg16672083 chr15:72433130 SENP8 0.41 6.26 0.33 1.23e-9 Red blood cell count; CRC cis rs780094 0.564 rs4665978 chr2:27648726 T/C cg21248554 chr2:27665150 KRTCAP3 -0.29 -6.89 -0.35 2.9e-11 Calcium levels;Fasting blood insulin;Metabolic traits;Triglyceride levels;Fasting plasma glucose;Urate levels in overweight individuals;Urate levels in obese individuals;Uric acid levels;Height;Age-related diseases, mortality and associated endophenotypes;Renal underexcretion gout;Fasting blood glucose (BMI interaction);Urate levels;Gondoic acid (20:1n-9) levels;Fasting blood insulin (BMI interaction);Triglycerides;Plasma omega-3 polyunsaturated fatty acid levels (docosapentaenoic acid);Type 2 diabetes;Nonalcoholic fatty liver disease;Hypertriglyceridemia;C-reactive protein;Age-related disease endophenotypes;LDL cholesterol;Metabolic syndrome;Crohn's disease;Alcohol consumption (drinks per week);Homeostasis model assessment of insulin resistance;Alcohol consumption;Red blood cell count;Fasting blood glucose; CRC cis rs17253792 0.731 rs74823888 chr14:56049800 T/C cg01858014 chr14:56050164 KTN1 -0.88 -7.09 -0.36 8.36e-12 Putamen volume; CRC cis rs2072499 1.000 rs2241107 chr1:156182710 C/T cg06970220 chr1:156163860 SLC25A44 -0.49 -7.09 -0.36 8.05e-12 Testicular germ cell tumor; CRC cis rs798554 0.757 rs960273 chr7:2857876 T/C cg19717773 chr7:2847554 GNA12 -0.49 -7.03 -0.36 1.19e-11 Height; CRC cis rs1707322 0.717 rs3014246 chr1:46086077 C/T cg03146154 chr1:46216737 IPP -0.65 -9.2 -0.45 4.11e-18 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs4862750 0.914 rs1991255 chr4:187875340 G/A cg22105103 chr4:187893119 NA 0.63 11.29 0.53 3.27e-25 Lobe attachment (rater-scored or self-reported); CRC cis rs9916302 0.680 rs2271308 chr17:37817482 T/C cg00129232 chr17:37814104 STARD3 -0.68 -11.75 -0.54 7.36e-27 Glomerular filtration rate (creatinine); CRC cis rs8141529 0.636 rs5762799 chr22:29187380 G/T cg15103426 chr22:29168792 CCDC117 0.49 6.01 0.31 5.05e-9 Lymphocyte counts; CRC cis rs3126085 1.000 rs1858482 chr1:152306921 A/G cg09127314 chr1:152161683 NA 0.49 6.02 0.31 4.77e-9 Atopic dermatitis; CRC cis rs6747952 0.899 rs2121404 chr2:239083826 A/G cg17459225 chr2:239074497 NA 0.45 7.7 0.39 1.63e-13 Mean corpuscular hemoglobin concentration; CRC cis rs3796619 1.000 rs12647929 chr4:1092019 G/T cg27284194 chr4:1044797 NA 0.41 6.31 0.33 8.77e-10 Recombination rate (males); CRC cis rs6860806 0.661 rs1588263 chr5:131577158 T/C cg18758796 chr5:131593413 PDLIM4 0.46 8.51 0.42 6.45e-16 Breast cancer; CRC cis rs3008870 1.000 rs3008858 chr1:67390416 G/C cg08660285 chr1:67390436 MIER1;WDR78 1.06 16.12 0.66 1.63e-43 Lymphocyte percentage of white cells; CRC cis rs763014 0.966 rs4247097 chr16:654224 G/A cg08989290 chr16:615782 NHLRC4 0.48 9.48 0.46 5.37e-19 Height; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg08413153 chr17:46185283 SNX11 0.44 6.1 0.32 3e-9 Response to antipsychotic treatment; CRC cis rs3785574 0.962 rs2584614 chr17:61929445 C/T cg23090583 chr17:61904693 PSMC5;FTSJ3 0.62 8.87 0.44 4.89e-17 Height; CRC cis rs9858542 0.953 rs35169793 chr3:49423274 A/G cg07274523 chr3:49395745 GPX1 0.45 6.05 0.32 4.03e-9 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC trans rs2303319 0.504 rs56965753 chr2:162597251 A/G cg22922770 chr7:98923339 ARPC1A -0.67 -5.98 -0.31 5.68e-9 Cognitive function; CRC cis rs8031584 0.541 rs2955777 chr15:31219788 A/C cg14829155 chr15:31115871 NA 0.36 5.76 0.3 1.89e-8 Huntington's disease progression; CRC trans rs9858542 0.953 rs12330269 chr3:49513910 G/A cg21665057 chr3:196295764 WDR53;FBXO45 -0.65 -8.86 -0.44 5.12e-17 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs540254 0.647 rs474918 chr1:160771197 C/T cg20255094 chr1:160771763 LY9 -0.5 -6.52 -0.34 2.64e-10 Blood protein levels; CRC trans rs7819412 0.806 rs6980856 chr8:10938260 A/G cg08975724 chr8:8085496 FLJ10661 0.43 6.39 0.33 5.7e-10 Triglycerides; CRC cis rs10857712 0.754 rs2297031 chr10:135232654 C/T cg01444801 chr10:135216882 MTG1 -0.55 -7.63 -0.39 2.5e-13 Systemic lupus erythematosus; CRC cis rs4380275 1.000 rs6548253 chr2:773655 A/G cg27237671 chr2:676223 TMEM18 -0.43 -6.11 -0.32 2.76e-9 Adverse response to chemotherapy (neutropenia/leucopenia) (doxorubicin); CRC cis rs2836974 0.966 rs7283516 chr21:40690537 A/G cg11890956 chr21:40555474 PSMG1 1.01 16.04 0.66 3.63e-43 Cognitive function; CRC cis rs2243480 1.000 rs13310597 chr7:65598540 A/G cg18252515 chr7:66147081 NA -1.24 -14.68 -0.63 7.09e-38 Diabetic kidney disease; CRC cis rs9326248 0.559 rs573549 chr11:116736679 A/G cg10398005 chr11:117014888 PAFAH1B2 -0.39 -5.84 -0.31 1.27e-8 Blood protein levels; CRC cis rs11212617 0.967 rs227040 chr11:108223391 T/C cg01991180 chr11:108092276 ATM;NPAT 0.43 6.43 0.33 4.52e-10 Response to metformin in type 2 diabetes (glycemic); CRC cis rs6998277 0.830 rs12543008 chr8:103603747 C/T cg10187029 chr8:103597600 NA 0.93 15.04 0.64 2.76e-39 Migraine; CRC cis rs2479724 0.935 rs62396748 chr6:41782007 A/G cg17623882 chr6:41773611 USP49 0.53 8.86 0.44 4.94e-17 Menarche (age at onset); CRC cis rs7617773 0.817 rs13068265 chr3:48301614 A/C cg11946769 chr3:48343235 NME6 0.71 9.55 0.47 3.2e-19 Coronary artery disease; CRC cis rs2832191 0.716 rs9983051 chr21:30371890 C/T cg24692254 chr21:30365293 RNF160 0.85 15.94 0.66 8.64e-43 Dental caries; CRC cis rs7937682 0.774 rs59921976 chr11:111473088 G/A cg19812747 chr11:111475976 SIK2 -0.58 -9.93 -0.48 1.68e-20 Primary sclerosing cholangitis; CRC cis rs3741151 0.773 rs73544767 chr11:73204619 C/T cg17517138 chr11:73019481 ARHGEF17 1.01 8.32 0.42 2.41e-15 GIP levels in response to oral glucose tolerance test (120 minutes); CRC cis rs2032447 0.832 rs10425 chr6:26056549 A/G cg26028573 chr6:26043587 HIST1H2BB 0.45 6.79 0.35 5.32e-11 Intelligence (multi-trait analysis); CRC cis rs12220238 1.000 rs2395077 chr10:75932001 A/G cg19889307 chr10:75911429 ADK;AP3M1 0.61 5.87 0.31 1.08e-8 Soluble interleukin-2 receptor subunit alpha; CRC cis rs7274811 0.744 rs2071054 chr20:32265839 A/G cg07470512 chr20:32255052 NECAB3;C20orf134 -0.44 -5.81 -0.31 1.48e-8 Height; CRC cis rs3818285 0.544 rs7899805 chr10:111671177 G/A cg00817464 chr10:111662876 XPNPEP1 -0.49 -6.78 -0.35 5.63e-11 Superior crus of antihelix expression; CRC cis rs9858542 0.537 rs9873994 chr3:49359943 T/C cg00383909 chr3:49044727 WDR6 0.67 6.96 0.36 1.82e-11 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs8180040 1.000 rs1638676 chr3:47327651 A/G cg02527881 chr3:46936655 PTH1R -0.4 -7.49 -0.38 6.52e-13 Colorectal cancer; CRC cis rs7937682 0.632 rs12785809 chr11:111776055 T/A cg19812747 chr11:111475976 SIK2 0.43 6.3 0.33 9.57e-10 Primary sclerosing cholangitis; CRC cis rs10504229 0.728 rs17215676 chr8:58152915 G/T cg22535103 chr8:58192502 C8orf71 -0.68 -8.37 -0.42 1.72e-15 Developmental language disorder (linguistic errors); CRC cis rs11098499 0.863 rs6858592 chr4:120458692 G/A cg09307838 chr4:120376055 NA 0.69 10.53 0.5 1.56e-22 Corneal astigmatism; CRC cis rs4148883 0.645 rs2851264 chr4:100029715 C/T cg12011299 chr4:100065546 ADH4 0.54 11.96 0.55 1.3e-27 Alcohol dependence; CRC cis rs6951245 0.935 rs79067319 chr7:1065548 C/T cg21664854 chr7:1097933 C7orf50;GPR146 0.76 8.59 0.43 3.47e-16 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs4731207 0.596 rs1600741 chr7:124692292 A/G cg23710748 chr7:124431027 NA -0.39 -6.22 -0.32 1.54e-9 Cutaneous malignant melanoma; CRC trans rs804280 1.000 rs804280 chr8:11612698 G/T cg06636001 chr8:8085503 FLJ10661 0.48 7.16 0.37 5.26e-12 Myopia (pathological); CRC cis rs10193935 0.901 rs222469 chr2:42640235 T/C cg27598129 chr2:42591480 NA -0.67 -7.83 -0.4 6.92e-14 Colonoscopy-negative controls vs population controls; CRC cis rs6502050 0.799 rs8082355 chr17:80120316 A/G cg19223190 chr17:80058835 NA 0.39 6.23 0.32 1.43e-9 Life satisfaction; CRC cis rs7703744 0.634 rs6884061 chr5:118683431 C/T cg23985447 chr5:118691066 TNFAIP8 0.45 6.6 0.34 1.64e-10 Lobe attachment (rater-scored or self-reported); CRC cis rs9309711 0.922 rs13431788 chr2:3482912 G/A cg10845886 chr2:3471009 TTC15 -0.71 -11.5 -0.54 6.13e-26 Neurofibrillary tangles; CRC cis rs6503525 0.628 rs4065985 chr17:38101932 G/C cg17467752 chr17:38218738 THRA 0.4 5.81 0.31 1.45e-8 Asthma; CRC cis rs977987 0.815 rs4887829 chr16:75488935 C/T cg03315344 chr16:75512273 CHST6 0.53 9.08 0.45 1e-17 Dupuytren's disease; CRC cis rs853679 0.517 rs55747925 chr6:28044337 T/C cg06470822 chr6:28175283 NA 0.98 13.17 0.59 4.07e-32 Depression; CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg04260516 chr14:24630327 IRF9 -0.49 -6.1 -0.32 3.04e-9 Diisocyanate-induced asthma; CRC cis rs7312933 0.612 rs10785334 chr12:42620377 A/G cg11827402 chr12:42719852 PPHLN1;ZCRB1 -0.64 -8.76 -0.43 1.03e-16 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CRC cis rs7680126 0.596 rs4698031 chr4:10315921 A/G cg00071950 chr4:10020882 SLC2A9 -0.45 -5.99 -0.31 5.53e-9 Urate levels in lean individuals;Urate levels in overweight individuals;Urate levels in obese individuals; CRC cis rs752010 0.841 rs58737163 chr1:42079821 G/T cg06885757 chr1:42089581 HIVEP3 0.32 5.7 0.3 2.7e-8 Lupus nephritis in systemic lupus erythematosus; CRC cis rs7927771 0.524 rs12362318 chr11:47682671 T/C cg20307385 chr11:47447363 PSMC3 0.46 6.78 0.35 5.48e-11 Subjective well-being; CRC cis rs10504229 0.596 rs6991216 chr8:58115586 T/C cg22535103 chr8:58192502 C8orf71 -0.7 -9.34 -0.46 1.47e-18 Developmental language disorder (linguistic errors); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg01947930 chr5:141016379 RELL2;HDAC3 0.39 6.26 0.33 1.2e-9 Liver disease severity in Alagille syndrome; CRC cis rs644799 0.648 rs1255176 chr11:95471465 A/T cg25622487 chr11:95524042 FAM76B;CEP57 0.48 7.05 0.36 1.09e-11 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs2282526 0.587 rs91424 chr21:44921161 A/G cg04455712 chr21:45112962 RRP1B -0.34 -5.87 -0.31 1.07e-8 Mean corpuscular hemoglobin; CRC cis rs13108904 0.870 rs4974578 chr4:1266072 A/G cg00684032 chr4:1343700 KIAA1530 0.48 7.1 0.36 7.89e-12 Obesity-related traits; CRC cis rs11608355 0.846 rs35393419 chr12:109881809 C/T cg19025524 chr12:109796872 NA -0.47 -5.93 -0.31 7.57e-9 Neuroticism; CRC cis rs798554 0.679 rs2644281 chr7:2886748 A/G cg19717773 chr7:2847554 GNA12 -0.41 -5.84 -0.31 1.22e-8 Height; CRC cis rs8180040 1.000 rs807810 chr3:47403892 G/A cg27129171 chr3:47204927 SETD2 -0.56 -8.85 -0.44 5.59e-17 Colorectal cancer; CRC cis rs4665809 1.000 rs10202478 chr2:26276049 T/C cg04944784 chr2:26401820 FAM59B -0.66 -8.59 -0.43 3.56e-16 Gut microbiome composition (summer); CRC cis rs262150 0.574 rs2730272 chr7:158798622 G/C cg12590608 chr7:158785262 NA 0.35 6.3 0.33 9.45e-10 Facial morphology (factor 20); CRC cis rs60871478 0.898 rs35928069 chr7:823067 G/C cg05535760 chr7:792225 HEATR2 0.79 10.38 0.5 5.05e-22 Cerebrospinal P-tau181p levels; CRC trans rs9858542 0.953 rs1987628 chr3:49399259 G/A cg21665057 chr3:196295764 WDR53;FBXO45 -0.62 -8.52 -0.43 5.85e-16 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs2806561 1.000 rs681753 chr1:23515216 T/C cg19743168 chr1:23544995 NA 0.37 5.78 0.3 1.75e-8 Height; CRC cis rs2213920 0.619 rs4979529 chr9:118197686 T/A cg13918206 chr9:118159781 DEC1 0.62 5.96 0.31 6.67e-9 Docetaxel-induced peripheral neuropathy in metastatic castrate-resistant prostate cancer; CRC cis rs8060686 0.858 rs7198357 chr16:67884619 A/G cg00318322 chr16:67708822 GFOD2 0.32 5.91 0.31 8.34e-9 HDL cholesterol;Metabolic syndrome; CRC trans rs3780486 0.505 rs10813959 chr9:33166234 C/T cg04842962 chr6:43655489 MRPS18A -0.89 -15.97 -0.66 6.36e-43 IgG glycosylation; CRC cis rs2731664 0.792 rs2731662 chr5:176872494 C/T cg23176889 chr5:176863531 GRK6 0.73 16.26 0.67 4.86e-44 Intelligence (multi-trait analysis); CRC cis rs8005677 1.000 rs7155857 chr14:23400059 C/A cg25600027 chr14:23388339 RBM23 -0.51 -7.86 -0.4 5.48e-14 Cognitive ability (multi-trait analysis); CRC cis rs9322193 0.683 rs113281309 chr6:150108425 T/G cg13206674 chr6:150067644 NUP43 0.57 8.14 0.41 8.29e-15 Lung cancer; CRC cis rs11711311 1.000 rs891574 chr3:113537639 C/A cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.49 -6.67 -0.35 1.08e-10 IgG glycosylation; CRC trans rs7142002 0.892 rs8005273 chr14:102364006 G/C cg24202123 chr3:36422093 STAC -0.48 -6.36 -0.33 6.64e-10 Autism; CRC cis rs66887589 0.775 rs6843229 chr4:120424087 T/C cg09307838 chr4:120376055 NA 0.55 8.47 0.42 8.17e-16 Diastolic blood pressure; CRC cis rs6540556 0.954 rs611861 chr1:209937251 C/G cg23920097 chr1:209922102 NA -0.49 -6.17 -0.32 1.98e-9 Red blood cell count; CRC cis rs736408 0.609 rs13095332 chr3:52787242 C/T cg08222913 chr3:52553049 STAB1 -0.34 -6.05 -0.32 3.94e-9 Bipolar disorder; CRC cis rs12762955 0.687 rs4880470 chr10:1077480 G/A cg26597838 chr10:835615 NA -0.49 -7.42 -0.38 1.04e-12 Response to angiotensin II receptor blocker therapy; CRC trans rs853679 0.607 rs34661125 chr6:28281894 G/A cg01620082 chr3:125678407 NA -0.81 -6.31 -0.33 8.98e-10 Depression; CRC cis rs7666738 0.830 rs13140676 chr4:98804978 C/T cg17366294 chr4:99064904 C4orf37 0.42 6.87 0.35 3.3e-11 Colonoscopy-negative controls vs population controls; CRC cis rs733592 0.507 rs7138917 chr12:48455255 G/A cg24011408 chr12:48396354 COL2A1 -0.43 -6.29 -0.33 1.02e-9 Plateletcrit; CRC cis rs514406 0.644 rs6661196 chr1:53203664 A/G cg08859206 chr1:53392774 SCP2 0.41 6.43 0.33 4.46e-10 Monocyte count; CRC cis rs801193 0.569 rs10950050 chr7:66239588 A/C cg18252515 chr7:66147081 NA -0.41 -6.06 -0.32 3.69e-9 Aortic root size; CRC cis rs2386661 0.547 rs11259582 chr10:5646767 C/T cg12223502 chr10:5658492 NA -0.37 -5.89 -0.31 9.57e-9 Breast cancer; CRC cis rs4594175 0.926 rs11624975 chr14:51628347 T/C cg23942311 chr14:51606299 NA 0.61 9.7 0.47 9.55e-20 Cancer; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg13294780 chr4:140005756 ELF2 0.38 6.36 0.33 6.73e-10 Liver disease severity in Alagille syndrome; CRC cis rs1799949 1.000 rs8176202 chr17:41230228 G/A cg01879757 chr17:41196368 BRCA1 -0.39 -5.82 -0.31 1.36e-8 Menopause (age at onset); CRC cis rs7607369 0.536 rs6436089 chr2:219668813 A/G cg02176678 chr2:219576539 TTLL4 -0.37 -5.9 -0.31 8.89e-9 Red blood cell count;Amyotrophic lateral sclerosis; CRC cis rs3749237 0.615 rs6792911 chr3:49429856 C/T cg07636037 chr3:49044803 WDR6 0.55 8.09 0.41 1.14e-14 Resting heart rate; CRC cis rs9467711 0.606 rs9379854 chr6:26362854 T/C cg16898833 chr6:26189333 HIST1H4D 0.75 6.55 0.34 2.26e-10 Autism spectrum disorder or schizophrenia; CRC cis rs1707322 1.000 rs785493 chr1:46584859 A/G cg06784218 chr1:46089804 CCDC17 -0.61 -10.54 -0.5 1.37e-22 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs9443645 0.901 rs4706079 chr6:79615208 G/A cg05283184 chr6:79620031 NA -0.57 -9.14 -0.45 6.4e-18 Intelligence (multi-trait analysis); CRC cis rs9379850 0.528 rs67575965 chr6:26196593 A/G cg01420254 chr6:26195488 NA 0.69 7.54 0.38 4.73e-13 Intelligence (multi-trait analysis); CRC cis rs921968 0.565 rs4674330 chr2:219595710 T/C cg02176678 chr2:219576539 TTLL4 -0.39 -6.19 -0.32 1.76e-9 Mean corpuscular hemoglobin concentration; CRC cis rs1152591 0.562 rs1262242 chr14:64653869 C/T cg21174375 chr14:64681225 SYNE2 0.4 6.48 0.34 3.43e-10 Atrial fibrillation; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg04640194 chr12:56754023 STAT2 0.57 8.3 0.42 2.82e-15 Response to antipsychotic treatment; CRC trans rs11581859 0.950 rs72728532 chr1:99297822 C/A cg12183875 chr3:169587454 LRRC31 0.27 6.27 0.33 1.13e-9 Response to cognitive-behavioural therapy in anxiety disorder; CRC trans rs561341 1.000 rs72821971 chr17:30269343 T/G cg20587970 chr11:113659929 NA -1.43 -20.28 -0.75 6.91e-60 Hip circumference adjusted for BMI; CRC cis rs2882667 0.690 rs7709789 chr5:138274451 C/T cg09476006 chr5:138032270 NA 0.58 9.89 0.48 2.25e-20 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs67517081 1 rs67517081 chr16:30987380 GT/G cg02466173 chr16:30829666 NA 0.56 8.05 0.41 1.57e-14 Mean corpuscular hemoglobin; CRC cis rs7617773 0.817 rs9311421 chr3:48293078 G/A cg11946769 chr3:48343235 NME6 0.62 8.51 0.42 6.44e-16 Coronary artery disease; CRC cis rs6424115 0.708 rs11803575 chr1:24182348 A/T cg10978503 chr1:24200527 CNR2 -0.44 -6.84 -0.35 3.85e-11 Immature fraction of reticulocytes; CRC cis rs992157 0.560 rs10932763 chr2:219085863 G/C cg04880052 chr2:219191631 PNKD -0.42 -6.64 -0.34 1.3100000000000001e-10 Colorectal cancer; CRC cis rs2303745 0.589 rs11882562 chr19:17395055 C/G cg15110403 chr19:17392923 ANKLE1 0.36 5.94 0.31 7.18e-9 Systemic lupus erythematosus; CRC cis rs801193 1.000 rs2003301 chr7:66147656 G/C cg11764359 chr7:65958608 NA -0.54 -8.37 -0.42 1.73e-15 Aortic root size; CRC cis rs6502050 0.731 rs34796376 chr17:80116635 G/T cg11859384 chr17:80120422 CCDC57 -0.38 -6.0 -0.31 5.13e-9 Life satisfaction; CRC cis rs12887734 0.524 rs4906364 chr14:104214342 C/G cg01849466 chr14:104193079 ZFYVE21 -0.43 -6.71 -0.35 8.54e-11 Schizophrenia;Autism spectrum disorder or schizophrenia; CRC cis rs1707322 0.685 rs6690926 chr1:46134978 T/C cg03146154 chr1:46216737 IPP 0.67 9.75 0.47 6.98e-20 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs11055034 0.560 rs2024385 chr12:12888438 A/T cg04607235 chr12:12878440 APOLD1 0.52 7.39 0.38 1.23e-12 Birth weight; CRC cis rs875971 0.862 rs6964437 chr7:65686444 A/G cg18252515 chr7:66147081 NA 0.41 5.76 0.3 1.96e-8 Aortic root size; CRC cis rs9486719 1.000 rs11153067 chr6:97039421 A/T cg06623918 chr6:96969491 KIAA0776 0.78 9.16 0.45 5.52e-18 Migraine;Coronary artery disease; CRC cis rs1223397 0.651 rs2496144 chr6:13311941 A/G cg20827128 chr6:13274284 PHACTR1 0.37 5.66 0.3 3.32e-8 Blood pressure; CRC cis rs4908760 0.965 rs1884352 chr1:8537289 G/A cg20416874 chr1:8611966 RERE -0.46 -6.7 -0.35 8.82e-11 Vitiligo; CRC cis rs9303401 0.646 rs7342863 chr17:57227010 G/A cg10487724 chr17:56770010 TEX14;RAD51C 0.43 6.56 0.34 2.1e-10 Cognitive test performance; CRC cis rs78456975 1.000 rs13416881 chr2:1554808 G/A cg12573674 chr2:1569213 NA -0.76 -7.84 -0.4 6.48e-14 Placebo response in major depressive disorder (% change in symptom score); CRC cis rs904251 0.600 rs11756241 chr6:37445101 C/T cg25019722 chr6:37503610 NA -0.38 -6.77 -0.35 6.05e-11 Cognitive performance; CRC cis rs7666738 0.830 rs10028505 chr4:98962310 C/A cg17366294 chr4:99064904 C4orf37 0.43 7.36 0.38 1.49e-12 Colonoscopy-negative controls vs population controls; CRC cis rs10208940 0.841 rs7581931 chr2:68791641 A/G cg12452813 chr2:68675892 NA 0.47 5.95 0.31 6.88e-9 Urate levels in lean individuals; CRC cis rs7666738 0.925 rs2865952 chr4:99040305 C/T cg05340658 chr4:99064831 C4orf37 0.52 7.42 0.38 1.01e-12 Colonoscopy-negative controls vs population controls; CRC cis rs4363385 0.818 rs558363 chr1:153010431 C/T cg25856811 chr1:152973957 SPRR3 -0.25 -6.99 -0.36 1.51e-11 Inflammatory skin disease; CRC cis rs2952156 0.684 rs881844 chr17:37810218 C/G cg07936489 chr17:37558343 FBXL20 -0.51 -7.52 -0.38 5.22e-13 Asthma; CRC cis rs7493 1.000 rs6968305 chr7:95042529 G/A cg20119798 chr7:94954144 PON1 -0.49 -6.2 -0.32 1.72e-9 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs6541297 0.941 rs6541294 chr1:230278826 A/G cg20703242 chr1:230279135 GALNT2 0.51 8.0 0.4 2.21e-14 Coronary artery disease; CRC cis rs35110281 0.805 rs4818843 chr21:45006607 C/T cg01579765 chr21:45077557 HSF2BP -0.33 -6.3 -0.33 9.52e-10 Mean corpuscular volume; CRC cis rs9381040 1.000 rs2093395 chr6:41155026 C/G cg09580153 chr6:41068724 NFYA;LOC221442 0.51 7.22 0.37 3.57e-12 Alzheimer's disease (late onset); CRC trans rs11165623 0.740 rs12126692 chr1:96889258 C/G cg10631902 chr5:14652156 NA 0.5 9.51 0.46 4.2e-19 Hip circumference;Waist circumference; CRC cis rs2760061 0.626 rs2796057 chr1:228124414 G/C cg18477163 chr1:228402036 OBSCN -0.37 -6.01 -0.31 4.79e-9 Diastolic blood pressure; CRC cis rs2235642 0.750 rs2859310 chr16:1656765 C/T cg26528668 chr16:1614120 IFT140 -0.36 -5.64 -0.3 3.58e-8 Coronary artery disease; CRC cis rs6502050 0.835 rs8070014 chr17:80115247 T/G cg19223190 chr17:80058835 NA 0.39 6.25 0.33 1.27e-9 Life satisfaction; CRC trans rs11039798 1.000 rs6485908 chr11:48652198 C/T cg03929089 chr4:120376271 NA -0.62 -6.14 -0.32 2.33e-9 Axial length; CRC trans rs9858542 0.953 rs11713474 chr3:49611457 A/G cg21659725 chr3:3221576 CRBN -0.75 -10.2 -0.49 2.05e-21 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs10504229 0.683 rs55881798 chr8:58106406 T/C cg02290350 chr8:58132656 NA -0.59 -8.01 -0.4 1.96e-14 Developmental language disorder (linguistic errors); CRC cis rs2070677 0.668 rs7899159 chr10:135431451 C/T cg20169779 chr10:135381914 SYCE1 -0.77 -10.64 -0.51 6.34e-23 Gout; CRC cis rs2920503 1.000 rs2920503 chr3:12324230 C/T cg23514324 chr3:12329213 PPARG 0.57 7.23 0.37 3.34e-12 LDL cholesterol; CRC cis rs11690935 0.571 rs1008151 chr2:172912098 G/A cg13550731 chr2:172543902 DYNC1I2 0.65 9.27 0.46 2.53e-18 Schizophrenia; CRC cis rs2197308 0.565 rs4123923 chr12:37857684 T/C cg26384229 chr12:38710491 ALG10B 0.67 8.78 0.44 9.08e-17 Morning vs. evening chronotype; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg26179948 chr7:28220645 JAZF1 0.42 6.23 0.32 1.41e-9 Response to antipsychotic treatment; CRC cis rs10504229 0.683 rs34804288 chr8:58117570 C/A cg24829409 chr8:58192753 C8orf71 -0.55 -8.03 -0.4 1.71e-14 Developmental language disorder (linguistic errors); CRC trans rs3749237 0.964 rs1799845 chr3:49847623 A/G cg21659725 chr3:3221576 CRBN 0.55 7.6 0.39 3.16e-13 Resting heart rate; CRC cis rs6502050 0.865 rs74480314 chr17:80117716 C/T cg13198984 chr17:80129470 CCDC57 0.46 8.24 0.41 4.11e-15 Life satisfaction; CRC cis rs11155671 0.530 rs7768665 chr6:150208024 G/A cg13206674 chr6:150067644 NUP43 0.48 6.95 0.36 1.93e-11 Testicular germ cell tumor; CRC cis rs2153535 0.580 rs9392223 chr6:8468650 G/A cg21535247 chr6:8435926 SLC35B3 0.5 7.56 0.38 3.95e-13 Motion sickness; CRC cis rs4862750 0.872 rs6830828 chr4:187897472 T/G cg11301795 chr4:187892539 NA -0.87 -19.83 -0.74 4.13e-58 Lobe attachment (rater-scored or self-reported); CRC cis rs2354432 0.607 rs4314933 chr1:146821386 T/C cg25205988 chr1:146714368 CHD1L 1.14 10.04 0.48 7.37e-21 Mitochondrial DNA levels; CRC cis rs763121 0.853 rs4821812 chr22:39075235 G/C cg06022373 chr22:39101656 GTPBP1 0.79 12.36 0.56 4.51e-29 Menopause (age at onset); CRC cis rs12477438 0.798 rs6761570 chr2:99577276 T/G cg14399236 chr2:99771627 LIPT1;TSGA10 -0.7 -9.74 -0.47 7.45e-20 Chronic sinus infection; CRC cis rs9660180 0.839 rs12040826 chr1:1705287 A/C cg03396347 chr1:1875803 NA -0.6 -9.22 -0.45 3.56e-18 Body mass index; CRC cis rs10751667 0.666 rs10794354 chr11:954615 A/T ch.11.42038R chr11:967971 AP2A2 0.57 9.75 0.47 6.98e-20 Alzheimer's disease (late onset); CRC cis rs1003719 0.788 rs2835592 chr21:38464387 G/A cg10648535 chr21:38446584 PIGP;TTC3 0.52 7.41 0.38 1.07e-12 Eye color traits; CRC cis rs526821 0.553 rs519637 chr11:55295935 A/T cg04317927 chr11:55418816 OR4S2 0.41 6.87 0.35 3.14e-11 Pediatric bone mineral density (spine); CRC cis rs3768617 0.811 rs10797828 chr1:183028430 G/A ch.1.3577855R chr1:183094577 LAMC1 0.62 9.07 0.45 1.11e-17 Fuchs's corneal dystrophy; CRC trans rs2243480 1.000 rs34529418 chr7:65403209 A/G cg10756647 chr7:56101905 PSPH 0.73 8.07 0.41 1.36e-14 Diabetic kidney disease; CRC cis rs853679 0.517 rs35227624 chr6:28132726 A/G cg18032046 chr6:28092343 ZSCAN16 -0.51 -5.93 -0.31 7.47e-9 Depression; CRC cis rs6088590 0.931 rs6088617 chr20:33408036 G/A cg24642439 chr20:33292090 TP53INP2 0.59 10.57 0.5 1.15e-22 Coronary artery disease; CRC cis rs4588572 0.644 rs10805920 chr5:77698222 G/A cg11547950 chr5:77652471 NA -0.5 -7.43 -0.38 9.69e-13 Triglycerides; CRC cis rs7927771 1.000 rs11039426 chr11:47863119 G/A cg18512352 chr11:47633146 NA -0.48 -9.36 -0.46 1.29e-18 Subjective well-being; CRC cis rs736408 0.521 rs13074853 chr3:52779801 T/C cg08222913 chr3:52553049 STAB1 -0.33 -6.12 -0.32 2.72e-9 Bipolar disorder; CRC cis rs2836974 0.897 rs2836928 chr21:40543320 C/T cg17971929 chr21:40555470 PSMG1 0.73 9.93 0.48 1.7e-20 Cognitive function; CRC cis rs4689388 0.750 rs10755148 chr4:6295064 A/G cg00701064 chr4:6280414 WFS1 0.62 9.52 0.46 3.85e-19 Type 2 diabetes and other traits;Type 2 diabetes; CRC cis rs1448094 0.511 rs17279338 chr12:86162874 G/A cg02569458 chr12:86230093 RASSF9 0.47 7.78 0.39 9.77e-14 Major depressive disorder; CRC trans rs6557786 0.636 rs17052934 chr8:24840319 A/C cg22103414 chr8:6638082 NA 0.31 6.0 0.31 5.21e-9 Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 2 peripheral neuropathy); CRC cis rs7613875 0.578 rs2624822 chr3:50107219 T/C cg24110177 chr3:50126178 RBM5 0.59 9.22 0.45 3.55e-18 Body mass index; CRC cis rs933688 0.941 rs2887007 chr5:90740531 A/T cg26981201 chr5:90679533 LOC100129716;ARRDC3 1.02 17.16 0.69 1.33e-47 Smoking behavior; CRC cis rs2084637 1.000 rs9633953 chr11:122419642 C/T cg21585512 chr11:122030076 LOC399959 -0.37 -6.62 -0.34 1.5e-10 Stroke; CRC cis rs9309473 0.687 rs6706409 chr2:73606508 G/T cg20560298 chr2:73613845 ALMS1 0.54 7.31 0.37 2.01e-12 Metabolite levels; CRC cis rs2408955 0.561 rs11168365 chr12:48421772 A/G cg00601486 chr12:48723148 H1FNT -0.33 -6.16 -0.32 2.09e-9 Glycated hemoglobin levels; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg08576880 chr16:1359158 UBE2I 0.45 5.97 0.31 6.2e-9 Anxiety disorder; CRC cis rs3824347 0.771 rs10746968 chr9:77579976 A/G cg01251476 chr9:77566080 C9orf40 0.38 5.83 0.31 1.35e-8 Urinary magnesium-to-creatinine ratio; CRC cis rs1552244 0.572 rs3774208 chr3:10164722 T/G cg16606324 chr3:10149918 C3orf24 0.66 7.74 0.39 1.19e-13 Alzheimer's disease; CRC trans rs208520 0.690 rs12213575 chr6:66735989 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 1.05 14.74 0.63 4.18e-38 Exhaled nitric oxide output; CRC cis rs672059 1.000 rs1760621 chr1:183156006 T/G ch.1.3577855R chr1:183094577 LAMC1 0.49 7.13 0.37 6.58e-12 Hypertriglyceridemia; CRC cis rs826838 0.654 rs7977738 chr12:38722460 G/A cg13010199 chr12:38710504 ALG10B 0.4 5.95 0.31 6.89e-9 Heart rate; CRC cis rs6933660 0.720 rs6936936 chr6:151753395 A/G cg14262678 chr6:151773367 RMND1;C6orf211 0.54 8.93 0.44 3.08e-17 Menarche (age at onset); CRC cis rs9649213 0.613 rs2286074 chr7:97952011 G/A cg24562669 chr7:97807699 LMTK2 0.42 7.04 0.36 1.1e-11 Prostate cancer (SNP x SNP interaction); CRC cis rs6973256 0.569 rs9649595 chr7:133385921 G/C cg10665199 chr7:133106180 EXOC4 0.5 7.95 0.4 2.94e-14 Intelligence (multi-trait analysis); CRC cis rs6964587 1.000 rs10281556 chr7:91660053 C/T cg17063962 chr7:91808500 NA -0.79 -14.53 -0.63 2.68e-37 Breast cancer; CRC trans rs10982213 0.830 rs2274163 chr9:117188714 C/T cg05863116 chr5:133562407 PPP2CA 0.39 6.13 0.32 2.49e-9 Interleukin-6 levels; CRC cis rs12745968 0.685 rs11164807 chr1:93234095 G/C cg17283838 chr1:93427260 FAM69A -0.43 -5.8 -0.3 1.58e-8 Bipolar disorder and schizophrenia; CRC cis rs10876993 0.890 rs799575 chr12:58069107 A/G cg18357645 chr12:58087776 OS9 0.6 8.45 0.42 9.37e-16 Celiac disease or Rheumatoid arthritis; CRC cis rs7894051 1.000 rs11101724 chr10:135192153 G/A cg24905316 chr10:135186343 ECHS1 0.59 6.1 0.32 2.98e-9 Lifespan; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg11897279 chr19:13044638 FARSA 0.48 7.11 0.36 7.22e-12 Intelligence (multi-trait analysis); CRC cis rs9362426 0.551 rs6912282 chr6:88103000 C/T cg08069147 chr6:88032118 GJB7;C6orf162 0.5 6.4 0.33 5.4e-10 Depressive episodes in bipolar disorder; CRC cis rs2549003 1.000 rs2549003 chr5:131829297 A/G cg21138405 chr5:131827807 IRF1 0.59 11.9 0.55 2.21e-27 Asthma (sex interaction); CRC cis rs1005277 0.522 rs1208684 chr10:38093936 G/A cg00409905 chr10:38381863 ZNF37A -0.64 -10.52 -0.5 1.73e-22 Extrinsic epigenetic age acceleration; CRC cis rs6496667 0.908 rs8039446 chr15:90853061 A/G cg04176472 chr15:90893244 GABARAPL3 -0.49 -7.1 -0.36 7.91e-12 Rheumatoid arthritis; CRC cis rs12325245 0.536 rs17821543 chr16:58540875 C/T cg26666090 chr16:58549219 SETD6 0.94 6.29 0.33 9.91e-10 Schizophrenia; CRC cis rs55823223 0.564 rs9894009 chr17:73850414 C/T cg10935138 chr17:73851978 WBP2 0.55 6.9 0.36 2.66e-11 Psoriasis; CRC cis rs28386778 0.897 rs6504184 chr17:61842408 A/T cg22520471 chr17:61851767 DDX42;CCDC47 0.74 11.57 0.54 3.22e-26 Prudent dietary pattern; CRC cis rs7949030 0.591 rs35880596 chr11:62369884 C/G cg13298116 chr11:62369859 EML3;MTA2 0.61 10.36 0.5 5.71e-22 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; CRC cis rs703842 0.642 rs11536137 chr12:58056426 C/A cg15848620 chr12:58087721 OS9 0.54 6.3 0.33 9.35e-10 Multiple sclerosis; CRC trans rs1455244 0.700 rs7229302 chr18:11508904 G/T cg11117765 chr4:7044873 CCDC96;TADA2B 0.45 6.91 0.36 2.48e-11 Schizophrenia; CRC cis rs728616 0.510 rs12768957 chr10:82187293 G/A cg05935833 chr10:81318306 SFTPA2 -0.54 -6.33 -0.33 8e-10 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs12913538 0.855 rs11071677 chr15:62896909 T/A cg09983546 chr15:62884068 NA 0.58 8.94 0.44 2.81e-17 Sleep depth; CRC cis rs9322193 0.923 rs9505826 chr6:149955048 A/G cg00933542 chr6:150070202 PCMT1 0.29 6.08 0.32 3.37e-9 Lung cancer; CRC trans rs7613875 0.600 rs2856237 chr3:50158774 A/G cg21659725 chr3:3221576 CRBN -0.45 -6.64 -0.34 1.33e-10 Body mass index; CRC cis rs9291683 0.546 rs13129453 chr4:10044784 T/C cg00071950 chr4:10020882 SLC2A9 0.63 11.19 0.52 7.86e-25 Bone mineral density; CRC cis rs6502050 0.799 rs8082355 chr17:80120316 A/G cg02741985 chr17:80059408 CCDC57 0.43 7.15 0.37 5.59e-12 Life satisfaction; CRC cis rs2274273 0.624 rs7151754 chr14:55788501 C/T cg10130446 chr14:55658398 DLGAP5 -0.41 -5.78 -0.3 1.72e-8 Protein biomarker; CRC cis rs6598955 0.724 rs12096059 chr1:26596709 G/A cg00852783 chr1:26633632 UBXN11 0.43 7.02 0.36 1.31e-11 Obesity-related traits; CRC cis rs2204008 0.837 rs7315255 chr12:37949279 G/A cg26384229 chr12:38710491 ALG10B 0.68 9.08 0.45 1.03e-17 Bladder cancer; CRC trans rs7615952 0.546 rs2922171 chr3:125343193 C/T cg00769240 chr8:12517080 NA -0.65 -7.34 -0.38 1.67e-12 Blood pressure (smoking interaction); CRC cis rs523522 0.962 rs9040 chr12:120900274 C/T cg27279351 chr12:120934652 DYNLL1 0.79 11.49 0.54 6.5e-26 High light scatter reticulocyte count; CRC cis rs6840360 0.550 rs6853955 chr4:152510806 G/A cg09659197 chr4:152720779 NA 0.31 5.69 0.3 2.77e-8 Intelligence (multi-trait analysis); CRC cis rs2046867 0.862 rs2322612 chr3:72830058 A/G cg25664220 chr3:72788482 NA -0.41 -6.06 -0.32 3.74e-9 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; CRC cis rs798554 0.644 rs1639040 chr7:2884116 G/T cg19346786 chr7:2764209 NA -0.38 -6.53 -0.34 2.54e-10 Height; CRC cis rs2072510 0.569 rs7134860 chr12:96390358 C/A cg09636302 chr12:96389483 HAL -0.52 -6.5 -0.34 3.02e-10 Metabolite levels (small molecules and protein measures); CRC cis rs561341 0.714 rs75861674 chr17:30304317 A/G cg23018236 chr17:30244563 NA -0.57 -7.55 -0.38 4.27e-13 Hip circumference adjusted for BMI; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg00586365 chr5:132948251 FSTL4 0.3 6.01 0.31 4.97e-9 Liver disease severity in Alagille syndrome; CRC cis rs12594515 0.874 rs8032878 chr15:45998015 A/G cg01629716 chr15:45996671 NA 0.4 8.3 0.42 2.79e-15 Waist circumference;Weight; CRC cis rs9368481 0.594 rs7768643 chr6:26891919 C/T cg18278486 chr6:26987575 LOC100270746;C6orf41 0.38 5.97 0.31 5.99e-9 Autism spectrum disorder or schizophrenia; CRC cis rs534126 0.778 rs10256011 chr7:142936243 G/A cg04039957 chr7:143013207 CLCN1 0.34 5.7 0.3 2.69e-8 Cancer; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg21054179 chr12:49412581 PRKAG1 0.42 6.03 0.32 4.52e-9 Anxiety disorder; CRC cis rs7772486 0.651 rs1292338 chr6:145967471 A/C cg23711669 chr6:146136114 FBXO30 -0.65 -10.66 -0.51 5.67e-23 Lobe attachment (rater-scored or self-reported); CRC cis rs1448094 0.556 rs61930632 chr12:86168937 A/C cg02569458 chr12:86230093 RASSF9 0.48 7.96 0.4 2.8e-14 Major depressive disorder; CRC trans rs10982213 0.830 rs2274163 chr9:117188714 C/T cg18269826 chr15:101459483 LRRK1 0.37 6.12 0.32 2.6e-9 Interleukin-6 levels; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg23376446 chr14:100752258 NA 0.42 6.13 0.32 2.48e-9 Response to antipsychotic treatment; CRC cis rs1008375 1.000 rs4698199 chr4:17656738 G/C cg02297831 chr4:17616191 MED28 0.44 5.92 0.31 8.12e-9 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs7044106 0.762 rs1158553 chr9:123400974 C/G cg09419670 chr9:123605666 PSMD5;LOC253039 0.69 10.64 0.51 6.45e-23 Hip circumference adjusted for BMI; CRC cis rs2777491 0.915 rs8036498 chr15:41603276 A/G cg18705301 chr15:41695430 NDUFAF1 -0.7 -11.6 -0.54 2.55e-26 Ulcerative colitis; CRC cis rs853679 0.517 rs4713135 chr6:28039586 G/A cg12963246 chr6:28129442 ZNF389 0.48 5.7 0.3 2.72e-8 Depression; CRC cis rs62244186 0.711 rs6778410 chr3:44743993 C/T cg15687855 chr3:44754131 ZNF502 -0.37 -6.19 -0.32 1.79e-9 Depressive symptoms; CRC cis rs453301 0.658 rs9650616 chr8:8869199 T/G cg06636001 chr8:8085503 FLJ10661 -0.48 -7.1 -0.36 7.58e-12 Joint mobility (Beighton score); CRC cis rs1552244 1.000 rs68067759 chr3:10150535 T/C cg10729496 chr3:10149963 C3orf24 0.53 6.92 0.36 2.3e-11 Alzheimer's disease; CRC cis rs6502050 0.740 rs4789748 chr17:80093061 A/C cg25804541 chr17:80189381 SLC16A3 -0.3 -5.88 -0.31 1e-8 Life satisfaction; CRC cis rs9926296 0.624 rs1110331 chr16:89774396 A/G cg03605463 chr16:89740564 NA 0.43 6.87 0.35 3.26e-11 Vitiligo; CRC cis rs7937682 0.824 rs11213962 chr11:111506027 G/A cg19812747 chr11:111475976 SIK2 -0.59 -10.07 -0.49 5.54e-21 Primary sclerosing cholangitis; CRC cis rs933688 0.938 rs6869048 chr5:90664322 G/C cg02339078 chr5:90679543 LOC100129716;ARRDC3 0.91 15.49 0.65 4.88e-41 Smoking behavior; CRC cis rs970548 0.865 rs12246131 chr10:45993782 A/T cg15590007 chr10:45870220 ALOX5 0.48 6.04 0.32 4.24e-9 Total cholesterol levels;Cholesterol, total;HDL cholesterol;HDL cholesterol levels; CRC cis rs11690935 1.000 rs6757773 chr2:172549630 T/A cg13550731 chr2:172543902 DYNC1I2 1.05 18.91 0.72 1.63e-54 Schizophrenia; CRC cis rs9296092 0.560 rs62407569 chr6:33538865 A/G cg13560919 chr6:33536144 NA -0.44 -6.26 -0.33 1.18e-9 Age at smoking initiation in chronic obstructive pulmonary disease; CRC cis rs227584 0.663 rs3180912 chr17:42259463 A/G cg10896456 chr17:42255109 ASB16;C17orf65 0.36 6.09 0.32 3.07e-9 Bone mineral density (hip);Bone mineral density; CRC cis rs76878669 0.561 rs7107191 chr11:66140397 G/A cg18002602 chr11:66138449 SLC29A2 0.28 6.05 0.32 3.98e-9 Educational attainment (years of education); CRC cis rs514406 0.505 rs269292 chr1:53187911 T/C cg24675658 chr1:53192096 ZYG11B -0.67 -10.16 -0.49 2.85e-21 Monocyte count; CRC trans rs12200782 0.649 rs9467742 chr6:26386363 A/G cg25800765 chr12:85673347 ALX1 0.26 5.96 0.31 6.54e-9 Small cell lung carcinoma; CRC cis rs10789491 1.000 rs618505 chr1:47144532 T/C cg15501359 chr1:47185051 KIAA0494 0.62 7.56 0.38 4.02e-13 Response to hepatitis C treatment; CRC cis rs76878669 0.515 rs947978 chr11:66108660 C/T cg24851651 chr11:66362959 CCS -0.38 -6.69 -0.35 9.66e-11 Educational attainment (years of education); CRC cis rs972578 0.837 rs4820496 chr22:43320301 A/G cg01576275 chr22:43409880 NA -0.38 -5.89 -0.31 9.6e-9 Mean platelet volume; CRC cis rs853679 0.517 rs4713137 chr6:28083521 C/G cg12273811 chr6:28175739 NA 0.73 9.18 0.45 4.85e-18 Depression; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg18588052 chr6:111408752 SLC16A10 0.36 6.05 0.32 3.86e-9 Liver disease severity in Alagille syndrome; CRC cis rs394563 0.591 rs6570963 chr6:149691355 T/G cg11245181 chr6:149772854 ZC3H12D 0.52 9.12 0.45 7.83e-18 Dupuytren's disease; CRC cis rs1552244 0.935 rs35515831 chr3:10071362 G/A cg13047869 chr3:10149882 C3orf24 0.52 7.13 0.37 6.56e-12 Alzheimer's disease; CRC cis rs17376456 0.825 rs12188163 chr5:93250608 A/G cg25358565 chr5:93447407 FAM172A -1.08 -10.41 -0.5 4.14e-22 Diabetic retinopathy; CRC cis rs938554 0.513 rs3775946 chr4:9995256 A/G cg00071950 chr4:10020882 SLC2A9 0.45 6.93 0.36 2.26e-11 Blood metabolite levels; CRC cis rs10504229 1.000 rs57186557 chr8:58177277 A/G cg24829409 chr8:58192753 C8orf71 -0.68 -11.34 -0.53 2.27e-25 Developmental language disorder (linguistic errors); CRC cis rs4722166 0.598 rs4722179 chr7:22803861 C/A cg05472934 chr7:22766657 IL6 0.65 10.59 0.5 9.6e-23 Lung cancer; CRC cis rs9462027 0.675 rs13206387 chr6:34696792 T/C cg07306190 chr6:34760872 UHRF1BP1 -0.35 -6.24 -0.33 1.38e-9 Systemic lupus erythematosus; CRC trans rs9329221 0.905 rs4433149 chr8:10249268 A/T cg08975724 chr8:8085496 FLJ10661 -0.45 -7.12 -0.37 6.88e-12 Neuroticism; CRC cis rs67340775 0.541 rs200966 chr6:27862152 T/C cg06470822 chr6:28175283 NA 0.82 8.57 0.43 3.96e-16 Lung cancer in ever smokers; CRC cis rs1018836 0.786 rs4734237 chr8:91533361 A/C cg16814680 chr8:91681699 NA 0.65 10.49 0.5 2.18e-22 Ejection fraction in Tripanosoma cruzi seropositivity; CRC cis rs1218582 0.772 rs6656435 chr1:154876869 G/A cg03351412 chr1:154909251 PMVK 0.54 8.68 0.43 1.92e-16 Prostate cancer; CRC cis rs2354432 1.000 rs6680778 chr1:146747153 T/C cg25205988 chr1:146714368 CHD1L 1.24 18.66 0.72 1.65e-53 Mitochondrial DNA levels; CRC cis rs769267 0.930 rs2301784 chr19:19390749 G/A cg03709012 chr19:19516395 GATAD2A 0.72 10.98 0.52 4.29e-24 Tonsillectomy; CRC cis rs6951245 0.580 rs77101766 chr7:1122438 A/G cg03188948 chr7:1209495 NA 0.55 6.38 0.33 6.15e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs11122272 0.766 rs2790870 chr1:231543823 A/G cg06096015 chr1:231504339 EGLN1 0.38 5.63 0.3 3.81e-8 Hemoglobin concentration; CRC cis rs7927771 0.698 rs34467936 chr11:47915299 A/G cg05585544 chr11:47624801 NA -0.6 -10.53 -0.5 1.5e-22 Subjective well-being; CRC cis rs7129220 0.512 rs1867137 chr11:10228809 G/A cg23875677 chr11:10229755 SBF2 -0.53 -5.97 -0.31 6.29e-9 Systolic blood pressure;Diastolic blood pressure;Blood pressure; CRC cis rs6547741 1.000 rs1919125 chr2:27801403 C/G cg27432699 chr2:27873401 GPN1 0.76 13.58 0.6 1.2e-33 Oral cavity cancer; CRC cis rs612683 0.826 rs7556246 chr1:100828914 A/G cg06223162 chr1:101003688 GPR88 0.38 6.87 0.35 3.3e-11 Breast cancer; CRC cis rs7208859 0.623 rs216423 chr17:28942109 G/C cg19761014 chr17:28927070 LRRC37B2 0.55 6.58 0.34 1.9e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs9733 0.596 rs1336898 chr1:150665050 G/A cg17724175 chr1:150552817 MCL1 0.58 9.4 0.46 9.25e-19 Tonsillectomy; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg02696742 chr7:106810147 HBP1 0.47 7.53 0.38 4.87e-13 Liver disease severity in Alagille syndrome; CRC cis rs7618915 0.547 rs2118540 chr3:52629386 T/C cg18099408 chr3:52552593 STAB1 -0.45 -7.3 -0.37 2.19e-12 Bipolar disorder; CRC cis rs921968 0.509 rs832813 chr2:219354569 T/C cg02176678 chr2:219576539 TTLL4 0.54 8.61 0.43 3.13e-16 Mean corpuscular hemoglobin concentration; CRC cis rs9368481 0.761 rs7775041 chr6:27009512 T/A cg12292205 chr6:26970375 C6orf41 -0.63 -9.71 -0.47 9.35e-20 Autism spectrum disorder or schizophrenia; CRC cis rs71403859 0.570 rs78972826 chr16:71454264 A/G cg08717414 chr16:71523259 ZNF19 -0.74 -8.19 -0.41 5.95e-15 Post bronchodilator FEV1; CRC cis rs9303280 0.837 rs907092 chr17:37922259 A/G cg00129232 chr17:37814104 STARD3 0.5 8.19 0.41 5.85e-15 Self-reported allergy; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg24991452 chr6:35996059 MAPK14 0.43 6.08 0.32 3.4e-9 Response to antipsychotic treatment; CRC cis rs4604732 0.536 rs76191272 chr1:247628055 A/T cg02104434 chr1:247694406 LOC148824;OR2C3 0.54 8.15 0.41 7.85e-15 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CRC cis rs7937682 0.632 rs10891297 chr11:111770150 C/T cg09085632 chr11:111637200 PPP2R1B 0.94 15.0 0.64 4.09e-39 Primary sclerosing cholangitis; CRC trans rs7873102 0.702 rs7028020 chr9:38007747 C/T cg09188016 chr12:64798414 XPOT -0.41 -6.38 -0.33 6.15e-10 Brain structure; CRC cis rs1881797 0.527 rs74227706 chr1:247638315 A/C cg21399703 chr1:247681439 NA 0.51 5.75 0.3 2e-8 Acute lymphoblastic leukemia (childhood); CRC cis rs2228479 0.850 rs17232630 chr16:89851179 C/T cg06656553 chr16:89960601 TCF25 -0.7 -5.81 -0.3 1.51e-8 Skin colour saturation; CRC cis rs6952808 0.760 rs11764960 chr7:1950532 G/A cg21782813 chr7:2030301 MAD1L1 0.44 7.38 0.38 1.3e-12 Bipolar disorder and schizophrenia; CRC cis rs9311474 0.502 rs4687624 chr3:52563572 C/T cg11645453 chr3:52864694 ITIH4 0.33 5.98 0.31 5.72e-9 Electroencephalogram traits; CRC cis rs10256972 0.553 rs4236381 chr7:1165723 A/C cg07092213 chr7:1199455 ZFAND2A -0.46 -6.49 -0.34 3.17e-10 Longevity;Endometriosis; CRC cis rs4662945 0.504 rs35568023 chr2:130251812 A/T cg05962382 chr2:130345044 NA -0.45 -7.72 -0.39 1.38e-13 Response to cytidine analogues (gemcitabine); CRC trans rs6952808 0.582 rs871925 chr7:2047875 G/A cg04565464 chr8:145669602 NFKBIL2 -0.43 -6.58 -0.34 1.82e-10 Bipolar disorder and schizophrenia; CRC cis rs3087591 0.960 rs12942397 chr17:29462498 C/A cg24425628 chr17:29625626 OMG;NF1 0.87 16.65 0.68 1.45e-45 Hip circumference; CRC cis rs9322193 0.962 rs6899661 chr6:150139229 T/C cg07701084 chr6:150067640 NUP43 0.48 6.69 0.35 9.85e-11 Lung cancer; CRC cis rs13108904 0.935 rs3755920 chr4:1243617 T/C cg20092199 chr4:1342459 KIAA1530 0.38 6.67 0.35 1.06e-10 Obesity-related traits; CRC cis rs870825 0.616 rs7678864 chr4:185635158 C/T cg04058563 chr4:185651563 MLF1IP 0.73 9.38 0.46 1.13e-18 Blood protein levels; CRC cis rs1552244 0.816 rs13059144 chr3:10010197 A/C cg08888203 chr3:10149979 C3orf24 0.63 8.39 0.42 1.48e-15 Alzheimer's disease; CRC cis rs7914558 0.966 rs3758543 chr10:104944744 C/G cg04362960 chr10:104952993 NT5C2 0.59 8.59 0.43 3.53e-16 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs7917772 0.582 rs4919663 chr10:104363293 T/C cg11453585 chr10:104263688 ACTR1A;SUFU 0.82 15.29 0.64 3.08e-40 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC cis rs10256972 0.706 rs12701970 chr7:1121958 T/C cg23978390 chr7:1156363 C7orf50 0.55 7.55 0.38 4.35e-13 Longevity;Endometriosis; CRC cis rs898097 0.510 rs10445242 chr17:80891666 G/T cg15664640 chr17:80829946 TBCD 0.47 7.93 0.4 3.37e-14 Breast cancer; CRC cis rs9467603 1.000 rs13200921 chr6:25790378 T/C cg16898833 chr6:26189333 HIST1H4D 0.78 6.46 0.34 3.78e-10 Intelligence (multi-trait analysis); CRC cis rs4972806 0.668 rs2072588 chr2:177042930 G/C cg03152288 chr2:177042942 NA 0.81 13.04 0.58 1.27e-31 IgG glycosylation; CRC cis rs2832191 0.740 rs6516890 chr21:30476812 T/A cg24692254 chr21:30365293 RNF160 0.71 12.56 0.57 7.85e-30 Dental caries; CRC cis rs11148252 0.508 rs11148260 chr13:53162643 A/C cg00495681 chr13:53174319 NA 0.88 16.62 0.68 1.76e-45 Lewy body disease; CRC cis rs79387448 0.745 rs72993720 chr2:103121269 A/T cg09003973 chr2:102972529 NA 0.68 7.56 0.38 3.99e-13 Gut microbiota (bacterial taxa); CRC cis rs951366 0.764 rs823141 chr1:205741426 T/C cg24503407 chr1:205819492 PM20D1 0.83 13.04 0.58 1.3e-31 Menarche (age at onset); CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg24285721 chr7:44046988 SPDYE1;POLR2J4 -0.38 -6.44 -0.33 4.22e-10 Obesity-related traits; CRC cis rs1691799 0.867 rs1168332 chr12:66761548 C/T cg16791601 chr12:66731901 HELB -0.72 -12.56 -0.57 8.2e-30 White blood cell count (basophil); CRC cis rs780096 0.526 rs2010087 chr2:27637235 C/T cg12000995 chr2:27665139 KRTCAP3 -0.3 -6.15 -0.32 2.22e-9 Total body bone mineral density; CRC cis rs4547160 0.821 rs951359 chr12:63482309 G/A cg26727693 chr12:63544175 AVPR1A -0.44 -7.96 -0.4 2.73e-14 Morning vs. evening chronotype; CRC cis rs6088813 1.000 rs4911494 chr20:33971914 C/T cg14752227 chr20:34000481 UQCC -0.36 -5.62 -0.3 3.99e-8 Height; CRC cis rs7224685 0.501 rs6502765 chr17:3901814 A/G cg09695851 chr17:3907499 NA 0.83 16.4 0.67 1.33e-44 Type 2 diabetes; CRC trans rs10155879 0.505 rs12704265 chr7:86142678 A/G cg00300859 chr18:55289375 NARS 0.54 5.96 0.31 6.36e-9 Interleukin-4 levels; CRC cis rs34375054 0.525 rs7133006 chr12:125606123 G/A cg05341575 chr12:125625032 AACS -0.35 -5.74 -0.3 2.18e-8 Post bronchodilator FEV1/FVC ratio; CRC cis rs1552244 0.816 rs17050701 chr3:10041554 A/G cg13047869 chr3:10149882 C3orf24 0.51 6.97 0.36 1.74e-11 Alzheimer's disease; CRC cis rs6860806 0.507 rs183898 chr5:131716902 C/G cg20512303 chr5:131592959 PDLIM4 -0.39 -6.78 -0.35 5.63e-11 Breast cancer; CRC cis rs6088580 0.609 rs6059845 chr20:33036500 G/A cg08999081 chr20:33150536 PIGU 0.61 11.53 0.54 4.57e-26 Glomerular filtration rate (creatinine); CRC cis rs780096 0.565 rs8179252 chr2:27746832 A/C cg17158414 chr2:27665306 KRTCAP3 -0.27 -5.86 -0.31 1.12e-8 Total body bone mineral density; CRC cis rs12024301 0.557 rs10911412 chr1:183662429 T/C cg11505048 chr1:183622726 RGL1;APOBEC4 0.71 6.24 0.33 1.33e-9 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs9649465 0.967 rs768680 chr7:123364127 T/C cg03229431 chr7:123269106 ASB15 -0.36 -5.67 -0.3 3.21e-8 Migraine; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg19514765 chr6:27805693 HIST1H2BN;HIST1H2AK 0.55 7.14 0.37 5.83e-12 Thyroid stimulating hormone; CRC trans rs10983614 1.000 rs7867776 chr9:120072627 A/G cg21790657 chr18:77675478 PQLC1 0.44 6.38 0.33 6.02e-10 Survival in pancreatic cancer; CRC cis rs11676348 0.846 rs4674257 chr2:218988774 A/G cg00012203 chr2:219082015 ARPC2 -0.44 -6.47 -0.34 3.56e-10 Ulcerative colitis; CRC cis rs4478858 0.735 rs7523438 chr1:31788313 C/T cg00250761 chr1:31883323 NA 0.42 7.98 0.4 2.44e-14 Alcohol dependence; CRC cis rs7739232 0.920 rs75728990 chr6:53528375 C/T cg15658676 chr6:53530538 KLHL31 -0.76 -5.9 -0.31 8.9e-9 Hip circumference adjusted for BMI; CRC cis rs4481887 0.504 rs4916110 chr1:248360783 T/C cg00666640 chr1:248458726 OR2T12 0.44 7.07 0.36 9.39e-12 Common traits (Other); CRC cis rs6988985 0.678 rs28491316 chr8:143992661 C/T cg10324643 chr8:143916377 GML 0.35 5.71 0.3 2.57e-8 Plasma androstenedione levels in resected early stage-receptor positive breast cancer; CRC cis rs7044106 0.791 rs10985008 chr9:123492960 G/A cg09419670 chr9:123605666 PSMD5;LOC253039 0.83 14.23 0.62 3.93e-36 Hip circumference adjusted for BMI; CRC cis rs3857067 0.901 rs4693368 chr4:95046907 G/A cg11021082 chr4:95130006 SMARCAD1 -0.38 -5.73 -0.3 2.27e-8 QT interval; CRC cis rs6762 0.719 rs28655651 chr11:837121 G/C cg16425592 chr11:842748 TSPAN4;POLR2L -0.56 -8.28 -0.42 3.15e-15 Mean platelet volume; CRC cis rs1552244 0.882 rs36006511 chr3:10054191 C/T cg13047869 chr3:10149882 C3orf24 0.53 7.05 0.36 1.03e-11 Alzheimer's disease; CRC cis rs922182 0.557 rs7161764 chr15:64202744 C/T cg01859228 chr15:64208452 DAPK2 0.37 5.61 0.3 4.2e-8 Blood protein levels; CRC cis rs1572438 0.811 rs6916756 chr6:880467 G/A cg13447295 chr6:887704 NA 0.55 8.4 0.42 1.4e-15 Aging; CRC cis rs713477 0.967 rs12887653 chr14:55911030 T/A cg13175173 chr14:55914753 NA -0.51 -9.64 -0.47 1.62e-19 Pediatric bone mineral content (femoral neck); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg25535838 chr15:30917991 ARHGAP11B 0.39 6.4 0.33 5.48e-10 Liver disease severity in Alagille syndrome; CRC cis rs6968419 0.747 rs2030977 chr7:115875359 G/C cg02561103 chr7:115862891 TES -0.42 -6.24 -0.33 1.32e-9 Intraocular pressure; CRC cis rs10751667 0.643 rs7479473 chr11:929111 C/T cg23136738 chr11:925521 AP2A2 -0.41 -6.8 -0.35 4.92e-11 Alzheimer's disease (late onset); CRC cis rs60843830 0.964 rs7584915 chr2:264227 G/A cg25945732 chr2:264204 ACP1;SH3YL1 0.72 11.88 0.55 2.54e-27 Spherical equivalent (joint analysis main effects and education interaction); CRC cis rs2576037 0.544 rs629097 chr18:44378097 T/C cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.53 -8.09 -0.41 1.15e-14 Personality dimensions; CRC cis rs9868809 0.881 rs6773261 chr3:48675064 A/G cg07636037 chr3:49044803 WDR6 -0.63 -6.35 -0.33 7.27e-10 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; CRC cis rs2243480 1.000 rs4718315 chr7:65648541 T/C cg25985355 chr7:65971099 NA 0.52 6.01 0.31 4.92e-9 Diabetic kidney disease; CRC cis rs4481887 0.800 rs10788780 chr1:248483598 G/A cg00666640 chr1:248458726 OR2T12 0.47 8.01 0.4 1.96e-14 Common traits (Other); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg07088328 chr8:38089161 DDHD2 0.44 6.77 0.35 5.83e-11 Liver disease severity in Alagille syndrome; CRC cis rs4750440 0.702 rs7917296 chr10:14029639 G/A cg00551146 chr10:14014579 FRMD4A 0.39 6.33 0.33 7.99e-10 Adiponectin levels; CRC trans rs13046373 0.905 rs4816372 chr21:32077414 A/T cg23957850 chr13:103528318 ERCC5 -0.39 -6.23 -0.32 1.47e-9 HDL cholesterol; CRC cis rs6963495 0.818 rs56055535 chr7:105163574 C/A cg13798780 chr7:105162888 PUS7 0.68 8.08 0.41 1.27e-14 Bipolar disorder (body mass index interaction); CRC cis rs875971 0.895 rs7782806 chr7:65657897 C/T cg12463550 chr7:65579703 CRCP -0.54 -7.69 -0.39 1.73e-13 Aortic root size; CRC cis rs3820068 0.603 rs35509554 chr1:15993514 C/T cg13390004 chr1:15929781 NA 0.52 7.01 0.36 1.32e-11 Systolic blood pressure; CRC trans rs587242 0.911 rs80336582 chr1:96901001 G/A cg10631902 chr5:14652156 NA 0.44 6.84 0.35 3.84e-11 Body mass index (joint analysis main effects and physical activity interaction);Body mass index in physically inactive individuals;Body mass index; CRC cis rs477692 0.569 rs1771448 chr10:131296201 A/G cg05714579 chr10:131428358 MGMT -0.53 -7.6 -0.39 3.04e-13 Response to temozolomide; CRC cis rs6032067 0.704 rs35009666 chr20:43786020 C/T cg10761708 chr20:43804764 PI3 0.48 5.62 0.3 4.06e-8 Blood protein levels; CRC cis rs4654899 1.000 rs4654905 chr1:21509558 A/G cg02927042 chr1:21476669 EIF4G3 -0.48 -7.58 -0.39 3.62e-13 Superior frontal gyrus grey matter volume; CRC cis rs501120 0.584 rs11238898 chr10:44679016 T/A cg09554077 chr10:44749378 NA 0.7 7.85 0.4 5.95e-14 Coronary artery disease;Coronary heart disease; CRC cis rs6840360 0.573 rs11099807 chr4:152269228 C/T cg09659197 chr4:152720779 NA 0.33 6.36 0.33 6.58e-10 Intelligence (multi-trait analysis); CRC cis rs9303280 0.806 rs35736272 chr17:38032680 T/C cg17344932 chr17:38183730 MED24;SNORD124 0.37 5.9 0.31 8.85e-9 Self-reported allergy; CRC trans rs12599106 0.770 rs12445057 chr16:34970274 C/G cg03395511 chr6:291903 DUSP22 -0.63 -8.72 -0.43 1.36e-16 Menopause (age at onset); CRC cis rs2282802 0.685 rs1529693 chr5:139678213 A/G cg26211634 chr5:139558579 C5orf32 0.42 7.28 0.37 2.47e-12 Intelligence (multi-trait analysis); CRC cis rs1799949 0.550 rs2343818 chr17:41409774 G/A cg19454999 chr17:41278357 BRCA1;NBR2 0.53 8.06 0.41 1.38e-14 Menopause (age at onset); CRC cis rs9291683 0.679 rs3756225 chr4:10094133 G/C cg00071950 chr4:10020882 SLC2A9 -0.52 -9.07 -0.45 1.1e-17 Bone mineral density; CRC cis rs7932354 0.550 rs10734549 chr11:46822686 C/A cg19486271 chr11:47235900 DDB2 -0.43 -6.48 -0.34 3.3e-10 Bone mineral density (hip);Bone mineral density; CRC cis rs2032447 0.670 rs198850 chr6:26104670 A/C cg03264133 chr6:25882463 NA 0.43 5.89 0.31 9.41e-9 Intelligence (multi-trait analysis); CRC cis rs9560113 0.959 rs9555803 chr13:112179560 G/T cg10483660 chr13:112241077 NA 0.36 5.81 0.3 1.49e-8 Menarche (age at onset); CRC cis rs10256972 0.552 rs6978842 chr7:1204599 A/C cg04025307 chr7:1156635 C7orf50 0.58 9.12 0.45 7.84e-18 Longevity;Endometriosis; CRC cis rs6665290 0.835 rs7549465 chr1:227214399 A/C cg10327440 chr1:227177885 CDC42BPA -0.96 -19.15 -0.73 1.84e-55 Myeloid white cell count; CRC cis rs1005277 0.579 rs1780115 chr10:38524773 C/T cg03665457 chr10:38645376 HSD17B7P2 -0.42 -5.96 -0.31 6.58e-9 Extrinsic epigenetic age acceleration; CRC trans rs13046373 0.905 rs4816372 chr21:32077414 A/T cg06660174 chr16:19892831 GPRC5B -0.41 -6.26 -0.33 1.22e-9 HDL cholesterol; CRC cis rs4713118 0.513 rs149944 chr6:28002818 C/T cg06470822 chr6:28175283 NA 0.79 12.11 0.56 3.54e-28 Parkinson's disease; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg24515799 chr6:149867235 PPIL4 0.41 6.64 0.34 1.28e-10 Liver disease severity in Alagille syndrome; CRC cis rs12995491 0.731 rs55705009 chr2:88500718 T/G cg14558114 chr2:88469736 THNSL2 -0.46 -6.68 -0.35 1.05e-10 Response to metformin (IC50); CRC cis rs807669 0.903 rs1780637 chr22:19178250 A/G cg02655711 chr22:19163373 SLC25A1 0.98 20.12 0.74 2.92e-59 Metabolite levels; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg18720285 chr11:15096341 CALCB 0.36 6.01 0.31 4.86e-9 Liver disease severity in Alagille syndrome; CRC cis rs7666738 0.688 rs4632667 chr4:98748299 A/G cg03676636 chr4:99064102 C4orf37 0.25 5.63 0.3 3.93e-8 Colonoscopy-negative controls vs population controls; CRC cis rs6896969 0.510 rs7730306 chr5:40423257 C/A cg09067459 chr5:40385259 NA 0.46 7.97 0.4 2.69e-14 Multiple sclerosis; CRC cis rs9368481 0.761 rs9357028 chr6:26967224 T/G cg18278486 chr6:26987575 LOC100270746;C6orf41 -0.48 -7.59 -0.39 3.23e-13 Autism spectrum disorder or schizophrenia; CRC cis rs10911251 0.528 rs2182020 chr1:183074964 C/T ch.1.3577855R chr1:183094577 LAMC1 0.87 15.46 0.65 6.33e-41 Colorectal cancer; CRC cis rs10227331 0.846 rs12673606 chr7:157297518 C/G cg06076350 chr7:157294107 NA 0.32 5.78 0.3 1.78e-8 Inattentive symptoms; CRC cis rs7927771 0.965 rs35184771 chr11:47475189 G/T cg20307385 chr11:47447363 PSMC3 -0.59 -8.15 -0.41 7.74e-15 Subjective well-being; CRC trans rs2727020 0.521 rs11039902 chr11:48679467 A/G cg15704280 chr7:45808275 SEPT13 -0.52 -7.5 -0.38 6.03e-13 Coronary artery disease; CRC cis rs1348850 0.914 rs1975544 chr2:178465423 G/A cg22681709 chr2:178499509 PDE11A -0.37 -6.33 -0.33 8.02e-10 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg22846949 chr16:14723829 PARN 0.44 6.17 0.32 2.02e-9 Response to antipsychotic treatment; CRC cis rs12887734 0.524 rs4900599 chr14:104283444 G/T cg01849466 chr14:104193079 ZFYVE21 -0.43 -6.77 -0.35 5.81e-11 Schizophrenia;Autism spectrum disorder or schizophrenia; CRC cis rs881375 0.678 rs10118357 chr9:123680068 C/T cg14255062 chr9:123606675 PSMD5;LOC253039 0.39 6.2 0.32 1.72e-9 Rheumatoid arthritis; CRC cis rs55702914 0.628 rs3849362 chr2:198308260 A/G cg10820045 chr2:198174542 NA -0.33 -5.74 -0.3 2.11e-8 Major depression and alcohol dependence; CRC cis rs2576037 0.526 rs1789152 chr18:44433092 G/T cg24750912 chr18:44543259 TCEB3CL;KATNAL2 0.29 5.92 0.31 7.97e-9 Personality dimensions; CRC cis rs9915657 0.803 rs12449851 chr17:70099002 C/T cg09344028 chr17:70110421 NA -0.53 -8.67 -0.43 2.01e-16 Thyroid hormone levels; CRC cis rs7091068 0.671 rs604489 chr10:95405408 T/C cg20715218 chr10:95462985 C10orf4 -0.47 -5.65 -0.3 3.4e-8 Urinary tract infection frequency; CRC cis rs853679 0.517 rs9393894 chr6:28112562 A/G cg03623178 chr6:28175578 NA 0.98 12.66 0.57 3.31e-30 Depression; CRC cis rs28655083 0.956 rs1485792 chr16:77100439 G/T cg01753188 chr16:77233325 SYCE1L;MON1B -0.58 -8.04 -0.41 1.68e-14 Lobe attachment (rater-scored or self-reported); CRC cis rs4713118 0.547 rs2116981 chr6:28067951 T/G cg15786705 chr6:28176104 NA 0.76 9.6 0.47 2.1e-19 Parkinson's disease; CRC cis rs1129187 0.837 rs3763236 chr6:42902508 C/T cg10862848 chr6:42927986 GNMT 0.36 8.64 0.43 2.49e-16 Alzheimer's disease in APOE e4+ carriers; CRC cis rs7937682 0.883 rs2212520 chr11:111462096 C/T cg09085632 chr11:111637200 PPP2R1B -0.94 -17.74 -0.7 7.01e-50 Primary sclerosing cholangitis; CRC cis rs1552244 0.938 rs67667957 chr3:10167264 G/C cg10729496 chr3:10149963 C3orf24 0.5 6.49 0.34 3.18e-10 Alzheimer's disease; CRC cis rs6121246 0.909 rs6119651 chr20:30259246 G/T cg18721089 chr20:30220636 NA -0.34 -5.71 -0.3 2.5e-8 Mean corpuscular hemoglobin; CRC cis rs4253772 0.591 rs8143066 chr22:46656607 C/T cg24881330 chr22:46731750 TRMU 0.6 7.13 0.37 6.33e-12 LDL cholesterol;Cholesterol, total; CRC cis rs6952808 0.929 rs34145223 chr7:1926237 G/A cg20295408 chr7:1910781 MAD1L1 -0.44 -6.23 -0.32 1.44e-9 Bipolar disorder and schizophrenia; CRC cis rs10752881 0.602 rs9425569 chr1:182942202 C/T ch.1.3577855R chr1:183094577 LAMC1 0.64 9.11 0.45 8.53e-18 Colorectal cancer; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg09317632 chr19:58838370 ZSCAN22 0.4 6.53 0.34 2.54e-10 Liver disease severity in Alagille syndrome; CRC trans rs10504229 0.906 rs58559296 chr8:58171714 T/C cg04077850 chr5:125800366 GRAMD3 0.37 6.27 0.33 1.15e-9 Developmental language disorder (linguistic errors); CRC cis rs6860806 0.661 rs2171247 chr5:131580234 G/T cg20512303 chr5:131592959 PDLIM4 0.34 6.33 0.33 7.86e-10 Breast cancer; CRC cis rs951366 0.789 rs1772148 chr1:205704580 A/T cg14159672 chr1:205819179 PM20D1 0.72 10.48 0.5 2.26e-22 Menarche (age at onset); CRC cis rs910316 0.810 rs77939209 chr14:75670070 A/G cg03030879 chr14:75389066 RPS6KL1 0.42 6.37 0.33 6.2e-10 Height; CRC cis rs713587 0.521 rs35177510 chr2:25089594 C/A cg22495460 chr2:25135724 ADCY3 -0.85 -16.16 -0.67 1.15e-43 Body mass index in non-asthmatics; CRC cis rs55788414 0.651 rs2317121 chr16:81182826 T/G cg06400318 chr16:81190750 PKD1L2 -0.59 -6.82 -0.35 4.38e-11 Left ventricular obstructive tract defect (maternal effect); CRC cis rs2296342 0.652 rs2296338 chr6:33630816 G/A cg14003231 chr6:33640908 ITPR3 0.36 5.91 0.31 8.45e-9 Schizophrenia; CRC cis rs9894429 1.000 rs3935543 chr17:79579874 T/C cg21028142 chr17:79581711 NPLOC4 0.39 8.62 0.43 2.89e-16 Eye color traits; CRC cis rs951366 0.617 rs708727 chr1:205767885 G/A cg06877462 chr1:205807181 PM20D1 0.38 6.0 0.31 5.31e-9 Menarche (age at onset); CRC cis rs62064224 0.675 rs12150479 chr17:30636200 T/A cg09324608 chr17:30823087 MYO1D 0.36 6.31 0.33 9.25e-10 Schizophrenia; CRC cis rs11792861 0.926 rs75128146 chr9:111833791 G/T cg05043794 chr9:111880884 C9orf5 -0.37 -6.63 -0.34 1.36e-10 Menarche (age at onset); CRC cis rs10876993 0.928 rs10877001 chr12:58083077 T/C cg18357645 chr12:58087776 OS9 -0.6 -8.39 -0.42 1.48e-15 Celiac disease or Rheumatoid arthritis; CRC cis rs7639513 0.767 rs2348201 chr3:12711696 A/G cg23032965 chr3:12705835 RAF1 0.64 9.81 0.48 4.32e-20 Itch intensity from mosquito bite; CRC cis rs9491140 0.539 rs980658 chr6:124690371 G/A cg05308643 chr6:124982296 NKAIN2 0.48 6.74 0.35 7.01e-11 Neuroticism; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg23049307 chr1:55353163 DHCR24 0.44 6.96 0.36 1.82e-11 Liver disease severity in Alagille syndrome; CRC cis rs3026101 0.671 rs57774467 chr17:5300205 A/G cg25236894 chr17:5323110 RPAIN;NUP88 0.42 6.9 0.36 2.74e-11 Body mass index; CRC cis rs12476592 0.516 rs6717060 chr2:63568608 G/A cg10828910 chr2:63850056 LOC388955 0.45 5.79 0.3 1.62e-8 Childhood ear infection; CRC cis rs2180341 1.000 rs6569482 chr6:127631371 C/T cg27446573 chr6:127587934 RNF146 0.99 14.65 0.63 8.94e-38 Breast cancer; CRC cis rs3772130 0.962 rs11721291 chr3:121563285 T/C cg20356878 chr3:121714668 ILDR1 0.52 8.21 0.41 5.11e-15 Cognitive performance; CRC cis rs736408 0.716 rs2300149 chr3:52822921 C/T cg08222913 chr3:52553049 STAB1 -0.34 -5.96 -0.31 6.47e-9 Bipolar disorder; CRC cis rs1348850 0.837 rs4243388 chr2:178284604 T/G cg22681709 chr2:178499509 PDE11A -0.4 -7.56 -0.38 4.12e-13 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs4819852 0.958 rs1034564 chr22:19984013 A/G cg07821417 chr22:19972146 ARVCF -0.47 -6.4 -0.33 5.4e-10 Pulse pressure; CRC trans rs6951245 1.000 rs77760339 chr7:1083927 G/T cg13565492 chr6:43139072 SRF -0.71 -7.27 -0.37 2.61e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg25802399 chr20:61847276 YTHDF1 0.39 6.39 0.33 5.65e-10 Liver disease severity in Alagille syndrome; CRC trans rs3780486 0.505 rs959749 chr9:33147858 T/C cg04842962 chr6:43655489 MRPS18A 0.94 16.6 0.68 2.23e-45 IgG glycosylation; CRC cis rs9611565 0.765 rs132907 chr22:41801268 A/C cg03806693 chr22:41940476 POLR3H 1.04 12.91 0.58 3.83e-31 Vitiligo; CRC cis rs6570726 0.837 rs419991 chr6:145864212 C/T cg23711669 chr6:146136114 FBXO30 0.7 12.46 0.57 1.8e-29 Lobe attachment (rater-scored or self-reported); CRC cis rs1997103 1.000 rs6951294 chr7:55400835 C/T cg17469321 chr7:55412551 NA 0.73 11.31 0.53 2.87e-25 QRS interval (sulfonylurea treatment interaction); CRC cis rs7394190 0.748 rs16930909 chr10:75561582 T/C cg07699608 chr10:75541558 CHCHD1 0.59 6.14 0.32 2.38e-9 Incident atrial fibrillation; CRC cis rs4731207 0.596 rs1994023 chr7:124580670 A/C cg23710748 chr7:124431027 NA -0.38 -6.09 -0.32 3.18e-9 Cutaneous malignant melanoma; CRC trans rs17685 0.725 rs7795291 chr7:75725206 C/A cg19862616 chr7:65841803 NCRNA00174 0.98 18.34 0.71 2.87e-52 Coffee consumption;Coffee consumption (cups per day); CRC cis rs9733 0.596 rs6587516 chr1:150623221 C/T cg17724175 chr1:150552817 MCL1 0.58 9.4 0.46 9.25e-19 Tonsillectomy; CRC cis rs1865760 0.516 rs10807007 chr6:26048931 A/C cg16482183 chr6:26056742 HIST1H1C 0.5 7.32 0.37 1.9e-12 Height; CRC cis rs9322193 0.923 rs35967444 chr6:149996724 G/A cg05861140 chr6:150128134 PCMT1 -0.36 -5.82 -0.31 1.42e-8 Lung cancer; CRC cis rs10504229 0.683 rs11781690 chr8:58132931 C/G cg21724239 chr8:58056113 NA 0.49 6.81 0.35 4.75e-11 Developmental language disorder (linguistic errors); CRC cis rs4654899 1.000 rs6426668 chr1:21396596 T/C cg02927042 chr1:21476669 EIF4G3 -0.49 -7.78 -0.39 9.32e-14 Superior frontal gyrus grey matter volume; CRC cis rs9399135 0.935 rs11759999 chr6:135370495 G/T cg24558204 chr6:135376177 HBS1L 0.49 7.74 0.39 1.21e-13 Red blood cell count; CRC cis rs10504229 0.683 rs11774645 chr8:58132921 G/C cg21724239 chr8:58056113 NA 0.74 9.41 0.46 8.98e-19 Developmental language disorder (linguistic errors); CRC cis rs10992471 0.603 rs4743873 chr9:95270781 C/T cg14631576 chr9:95140430 CENPP 0.4 7.07 0.36 9.24e-12 Visceral adipose tissue/subcutaneous adipose tissue ratio; CRC cis rs11809207 0.523 rs2783628 chr1:26501827 A/C cg24519413 chr1:26490540 NA 0.38 6.37 0.33 6.44e-10 Height; CRC cis rs7647973 1.000 rs2140270 chr3:49439440 A/G cg07636037 chr3:49044803 WDR6 -0.65 -7.81 -0.4 7.8e-14 Menarche (age at onset); CRC cis rs754466 0.580 rs1866437 chr10:79526766 A/G cg17075019 chr10:79541650 NA -0.94 -17.12 -0.69 1.97e-47 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs10504229 1.000 rs116444534 chr8:58181915 A/G cg22535103 chr8:58192502 C8orf71 -0.77 -11.67 -0.54 1.49e-26 Developmental language disorder (linguistic errors); CRC cis rs7927771 1.000 rs7120333 chr11:47817441 C/T cg20307385 chr11:47447363 PSMC3 -0.49 -6.56 -0.34 2.04e-10 Subjective well-being; CRC cis rs6424115 0.737 rs10917430 chr1:24170458 C/T cg08896387 chr1:24191740 FUCA1 0.53 7.0 0.36 1.45e-11 Immature fraction of reticulocytes; CRC cis rs12824058 0.831 rs7310433 chr12:130809289 C/T cg26677194 chr12:130822605 PIWIL1 0.45 7.19 0.37 4.42e-12 Menopause (age at onset); CRC cis rs720844 1.000 rs6761549 chr2:149352262 T/A cg09247360 chr2:149335327 NA -0.63 -7.74 -0.39 1.21e-13 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs2839186 0.872 rs2250213 chr21:47674275 G/A cg13126279 chr21:47581558 C21orf56 -0.38 -5.72 -0.3 2.41e-8 Testicular germ cell tumor; CRC cis rs12142240 0.698 rs66575205 chr1:46814092 T/G cg14993813 chr1:46806288 NSUN4 -0.5 -6.42 -0.33 4.75e-10 Menopause (age at onset); CRC cis rs6502050 0.835 rs8065981 chr17:80091393 G/T cg02741985 chr17:80059408 CCDC57 0.43 7.11 0.36 7.33e-12 Life satisfaction; CRC cis rs61776719 0.520 rs12569027 chr1:38449163 C/T cg26398791 chr1:38455867 SF3A3 -0.44 -5.89 -0.31 9.39e-9 Coronary artery disease; CRC cis rs1129187 0.755 rs2274514 chr6:42934500 C/T cg02359409 chr6:42947317 PEX6 -0.7 -11.83 -0.55 3.96e-27 Alzheimer's disease in APOE e4+ carriers; CRC trans rs1814175 0.817 rs4881658 chr11:49941123 G/A cg15704280 chr7:45808275 SEPT13 -0.97 -18.49 -0.71 7.45e-53 Height; CRC cis rs9463078 0.702 rs929614 chr6:44771934 C/A cg25276700 chr6:44698697 NA -0.27 -6.81 -0.35 4.71e-11 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; CRC cis rs1577917 1.000 rs12204365 chr6:86700532 T/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.52 -6.8 -0.35 5.06e-11 Response to antipsychotic treatment; CRC cis rs6089584 0.850 rs6142938 chr20:60627723 A/C cg18761221 chr20:60518478 NA 0.47 7.72 0.39 1.37e-13 Body mass index; CRC cis rs7618915 0.547 rs2118540 chr3:52629386 T/C cg08222913 chr3:52553049 STAB1 -0.34 -6.17 -0.32 1.98e-9 Bipolar disorder; CRC cis rs274567 0.501 rs272855 chr5:131687175 C/T cg18758796 chr5:131593413 PDLIM4 0.4 6.32 0.33 8.41e-10 Blood metabolite levels; CRC cis rs6860806 0.507 rs2631369 chr5:131705266 G/C cg18301423 chr5:131593218 PDLIM4 -0.41 -7.02 -0.36 1.3e-11 Breast cancer; CRC cis rs9287719 0.934 rs6710033 chr2:10757677 C/T cg00105475 chr2:10696890 NA 0.44 7.14 0.37 6.13e-12 Prostate cancer; CRC cis rs12681288 0.578 rs56702775 chr8:968860 G/A cg15309053 chr8:964076 NA 0.48 7.69 0.39 1.76e-13 Schizophrenia; CRC cis rs4713118 0.869 rs6914924 chr6:27711530 C/T cg06470822 chr6:28175283 NA 0.71 10.07 0.49 5.85e-21 Parkinson's disease; CRC cis rs1983170 0.736 rs745731 chr1:92011467 G/T cg21854759 chr1:92012499 NA 0.51 6.07 0.32 3.52e-9 Eosinophil percentage of white cells; CRC cis rs9659323 1.000 rs6700415 chr1:119516174 A/T cg26570165 chr1:119541833 NA -0.38 -6.42 -0.33 4.75e-10 Body mass index; CRC cis rs9287719 0.967 rs12464817 chr2:10707212 A/G cg00105475 chr2:10696890 NA 0.47 7.53 0.38 4.96e-13 Prostate cancer; CRC cis rs9517320 0.515 rs1107379 chr13:99198921 C/T cg20487152 chr13:99095054 FARP1 -0.46 -6.7 -0.35 8.95e-11 Longevity; CRC cis rs3790844 0.613 rs12030331 chr1:200001547 G/A cg13229857 chr1:200006247 NR5A2 0.52 7.48 0.38 6.7e-13 Pancreatic cancer; CRC cis rs875971 0.789 rs28815324 chr7:65565776 A/T cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.62 -7.83 -0.4 6.78e-14 Aortic root size; CRC cis rs2576037 0.526 rs626217 chr18:44429182 T/G cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.54 9.25 0.45 2.87e-18 Personality dimensions; CRC cis rs9486715 0.838 rs9386473 chr6:96873341 C/A cg06623918 chr6:96969491 KIAA0776 0.98 18.05 0.71 4.09e-51 Headache; CRC cis rs4713118 0.527 rs35949862 chr6:28115367 A/G cg12273811 chr6:28175739 NA 0.73 9.16 0.45 5.8e-18 Parkinson's disease; CRC cis rs9393692 0.875 rs9358917 chr6:26284417 T/C cg13736514 chr6:26305472 NA -0.61 -11.46 -0.53 8.56e-26 Educational attainment; CRC cis rs537626 1.000 rs612611 chr11:69307463 A/G cg08353955 chr11:69289746 NA -0.57 -6.12 -0.32 2.72e-9 Breast cancer (early onset); CRC cis rs4713118 0.955 rs9393848 chr6:27688369 C/T cg12273811 chr6:28175739 NA 0.52 7.15 0.37 5.76e-12 Parkinson's disease; CRC cis rs7113874 0.610 rs12576736 chr11:8512281 A/C cg20771178 chr11:8615675 STK33 -0.35 -5.75 -0.3 2.05e-8 Body mass index in physically active individuals;Body mass index (joint analysis main effects and physical activity interaction); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg15395842 chr19:489248 NA 0.44 6.22 0.32 1.49e-9 Response to antipsychotic treatment; CRC cis rs3820068 0.581 rs6692461 chr1:15928449 A/G cg13390004 chr1:15929781 NA 0.5 7.16 0.37 5.45e-12 Systolic blood pressure; CRC cis rs9916302 0.904 rs4794813 chr17:37670994 A/T cg15445000 chr17:37608096 MED1 0.41 8.89 0.44 4.13e-17 Glomerular filtration rate (creatinine); CRC cis rs733592 0.723 rs10875766 chr12:48593580 G/C cg21466736 chr12:48725269 NA -0.49 -7.71 -0.39 1.46e-13 Plateletcrit; CRC cis rs1448094 0.838 rs28509446 chr12:86312584 A/C cg02569458 chr12:86230093 RASSF9 0.35 5.84 0.31 1.25e-8 Major depressive disorder; CRC cis rs9322193 0.884 rs9322210 chr6:150016576 G/A cg07701084 chr6:150067640 NUP43 0.56 8.31 0.42 2.47e-15 Lung cancer; CRC cis rs860295 0.702 rs12047756 chr1:155624944 G/A cg02153340 chr1:155202674 NA -0.57 -6.94 -0.36 2.1e-11 Body mass index; CRC cis rs4713118 0.505 rs276371 chr6:27910708 A/T cg21251018 chr6:28226885 NKAPL 0.55 8.9 0.44 3.96e-17 Parkinson's disease; CRC cis rs561341 0.883 rs1034626 chr17:30219500 C/G cg00745463 chr17:30367425 LRRC37B 0.67 8.05 0.41 1.51e-14 Hip circumference adjusted for BMI; CRC cis rs72781680 0.821 rs2339887 chr2:24198376 G/A cg08917208 chr2:24149416 ATAD2B 0.57 6.87 0.35 3.26e-11 Lymphocyte counts; CRC cis rs3892630 0.878 rs1559177 chr19:33210646 A/G cg22980127 chr19:33182716 NUDT19 0.93 11.07 0.52 1.96e-24 Red blood cell traits; CRC cis rs1707322 1.000 rs785493 chr1:46584859 A/G cg03146154 chr1:46216737 IPP -0.59 -8.06 -0.41 1.44e-14 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs7932354 0.528 rs747650 chr11:47176005 C/T cg03339077 chr11:47165057 C11orf49 -0.46 -6.54 -0.34 2.4e-10 Bone mineral density (hip);Bone mineral density; CRC cis rs2033711 0.870 rs7408188 chr19:58939389 T/G cg00825309 chr19:58991885 ZNF446 -0.45 -6.6 -0.34 1.64e-10 Uric acid clearance; CRC cis rs939584 0.778 rs12992154 chr2:632300 G/T cg03610516 chr2:642275 NA 0.42 5.64 0.3 3.58e-8 Body mass index; CRC cis rs1448094 0.511 rs61930074 chr12:86218759 G/C cg00310523 chr12:86230176 RASSF9 0.38 6.4 0.33 5.44e-10 Major depressive disorder; CRC trans rs7395662 0.929 rs11493665 chr11:48721035 A/G cg21153622 chr11:89784906 NA -0.48 -7.79 -0.39 8.83e-14 HDL cholesterol; CRC trans rs1814175 0.817 rs6486046 chr11:49997017 T/C cg03929089 chr4:120376271 NA -0.94 -17.8 -0.7 4.15e-50 Height; CRC cis rs7216064 1.000 rs9897982 chr17:65879592 G/T cg12091567 chr17:66097778 LOC651250 -0.62 -7.62 -0.39 2.81e-13 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CRC cis rs951366 0.789 rs823110 chr1:205701078 G/C cg26354017 chr1:205819088 PM20D1 0.74 11.12 0.52 1.29e-24 Menarche (age at onset); CRC cis rs734999 0.588 rs2843401 chr1:2528133 T/C cg18854424 chr1:2615690 NA -0.41 -7.81 -0.4 7.67e-14 Ulcerative colitis; CRC trans rs11466653 0.661 rs11466619 chr4:38780431 T/G cg11403706 chr22:49042600 FAM19A5 0.62 6.09 0.32 3.16e-9 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs2404602 0.716 rs12437627 chr15:76845050 T/C cg23625390 chr15:77176239 SCAPER 0.5 7.45 0.38 8.38e-13 Blood metabolite levels; CRC trans rs1455244 0.700 rs7229302 chr18:11508904 G/T cg25834275 chr19:3359809 NFIC 0.44 6.67 0.35 1.11e-10 Schizophrenia; CRC cis rs13118159 0.714 rs6843025 chr4:1334418 C/G cg23123621 chr4:1343375 KIAA1530 0.38 6.89 0.35 2.9e-11 Longevity; CRC cis rs7917772 0.636 rs4919674 chr10:104522226 T/C cg22532475 chr10:104410764 TRIM8 0.33 5.62 0.3 4e-8 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC cis rs6502050 0.805 rs9898507 chr17:80119628 C/T cg22110888 chr17:80059540 CCDC57 0.4 6.38 0.33 5.96e-10 Life satisfaction; CRC cis rs881375 0.967 rs2239658 chr9:123671837 A/G cg09419670 chr9:123605666 PSMD5;LOC253039 0.57 8.46 0.42 9.11e-16 Rheumatoid arthritis; CRC cis rs6496667 0.600 rs3902286 chr15:91075375 A/G cg04176472 chr15:90893244 GABARAPL3 -0.5 -7.51 -0.38 5.47e-13 Rheumatoid arthritis; CRC cis rs6964587 0.967 rs4729015 chr7:91561592 T/G cg17063962 chr7:91808500 NA -0.77 -13.0 -0.58 1.76e-31 Breast cancer; CRC cis rs644799 1.000 rs2508289 chr11:95624669 A/G cg25622487 chr11:95524042 FAM76B;CEP57 0.74 11.28 0.53 3.76e-25 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC trans rs916888 0.610 rs199454 chr17:44800110 G/A cg10053473 chr17:62856997 LRRC37A3 0.61 8.56 0.43 4.26e-16 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs4975616 0.773 rs414965 chr5:1324121 G/A cg26373071 chr5:1325741 CLPTM1L 0.47 8.35 0.42 1.87e-15 Lung cancer; CRC cis rs4713118 0.581 rs200504 chr6:27785820 T/C cg20933634 chr6:27740509 NA 0.59 7.05 0.36 1.05e-11 Parkinson's disease; CRC cis rs6076065 0.683 rs1419010 chr20:23365254 G/C cg11657817 chr20:23433608 CST11 0.47 6.9 0.36 2.64e-11 Facial morphology (factor 15, philtrum width); CRC cis rs10504229 1.000 rs6987435 chr8:58177334 G/A cg24829409 chr8:58192753 C8orf71 -0.67 -11.03 -0.52 2.75e-24 Developmental language disorder (linguistic errors); CRC trans rs7615952 0.932 rs13065725 chr3:125632289 C/A cg07211511 chr3:129823064 LOC729375 -1.2 -18.39 -0.71 1.85e-52 Blood pressure (smoking interaction); CRC cis rs2479724 0.935 rs2254936 chr6:41846569 A/G cg17623882 chr6:41773611 USP49 -0.56 -9.71 -0.47 8.83e-20 Menarche (age at onset); CRC trans rs2727020 0.729 rs588458 chr11:49214048 C/A cg15704280 chr7:45808275 SEPT13 0.86 14.88 0.63 1.18e-38 Coronary artery disease; CRC trans rs4586057 0.812 rs12256605 chr10:92621473 G/C cg26894278 chr13:21016241 CRYL1 0.38 6.29 0.33 9.83e-10 Economic and political preferences (time); CRC cis rs10504229 0.679 rs11786328 chr8:58039269 A/G cg11062466 chr8:58055876 NA 0.52 6.38 0.33 6.02e-10 Developmental language disorder (linguistic errors); CRC cis rs2050392 0.517 rs2480299 chr10:30743197 G/A cg18806716 chr10:30721971 MAP3K8 -0.6 -8.53 -0.43 5.57e-16 Inflammatory bowel disease; CRC cis rs6758955 1.000 rs1558628 chr2:10478422 C/T cg15773312 chr2:10472214 HPCAL1 0.66 8.62 0.43 2.79e-16 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; CRC cis rs270601 0.770 rs61352298 chr5:131600589 G/C cg04518342 chr5:131593106 PDLIM4 0.52 9.66 0.47 1.37e-19 Acylcarnitine levels; CRC cis rs12444156 1 rs12444156 chr16:71841257 C/T cg08717414 chr16:71523259 ZNF19 -0.99 -9.24 -0.45 3.21e-18 Post bronchodilator FEV1; CRC cis rs954108 0.809 rs1792023 chr13:29368502 G/A cg11788234 chr13:29393811 NA -0.42 -6.6 -0.34 1.64e-10 Obesity-related traits; CRC cis rs6912958 0.535 rs1753154 chr6:88032843 G/C cg12350822 chr6:88032061 C6orf162;GJB7 0.49 10.04 0.48 6.97e-21 Monocyte percentage of white cells; CRC cis rs4363385 0.747 rs4845507 chr1:152968414 T/G cg25856811 chr1:152973957 SPRR3 -0.25 -6.99 -0.36 1.58e-11 Inflammatory skin disease; CRC cis rs9902453 0.780 rs62068621 chr17:28170382 A/G cg26525008 chr17:28256777 EFCAB5;SSH2 0.58 8.63 0.43 2.65e-16 Coffee consumption (cups per day); CRC cis rs3857536 0.813 rs6455084 chr6:66935658 A/T cg07460842 chr6:66804631 NA -0.43 -5.81 -0.3 1.48e-8 Blood trace element (Cu levels); CRC cis rs11763147 1 rs11763147 chr7:65326821 C/T cg11764359 chr7:65958608 NA -0.52 -8.27 -0.41 3.34e-15 Corneal structure; CRC cis rs34172651 0.517 rs2547040 chr16:24736408 G/C cg06028605 chr16:24865363 SLC5A11 -0.58 -9.51 -0.46 4.07e-19 Intelligence (multi-trait analysis); CRC cis rs9322193 0.923 rs12205092 chr6:150082511 G/T cg04369109 chr6:150039330 LATS1 -0.46 -6.13 -0.32 2.56e-9 Lung cancer; CRC cis rs10751667 0.666 rs4074235 chr11:977511 C/G ch.11.42038R chr11:967971 AP2A2 0.58 9.98 0.48 1.16e-20 Alzheimer's disease (late onset); CRC cis rs7666738 0.716 rs13108535 chr4:99046324 A/G cg05340658 chr4:99064831 C4orf37 0.6 9.35 0.46 1.4e-18 Colonoscopy-negative controls vs population controls; CRC cis rs10924970 0.578 rs12025973 chr1:235463888 G/A cg09010748 chr1:235293032 TOMM20 -0.43 -5.92 -0.31 8.25e-9 Asthma; CRC cis rs7615952 0.673 rs115942855 chr3:125601960 G/A cg05084668 chr3:125655381 ALG1L -0.76 -8.49 -0.42 7.21e-16 Blood pressure (smoking interaction); CRC cis rs2811415 0.597 rs56380765 chr3:127768878 C/A cg13719885 chr3:127795394 NA -0.37 -5.65 -0.3 3.49e-8 Lung function (FEV1/FVC); CRC cis rs7107174 1.000 rs4944198 chr11:78032605 T/A cg02023728 chr11:77925099 USP35 0.49 8.04 0.41 1.61e-14 Testicular germ cell tumor; CRC cis rs2898681 0.519 rs3811781 chr4:53729166 T/G cg26260408 chr4:53727979 RASL11B 0.41 5.96 0.31 6.67e-9 Optic nerve measurement (cup area); CRC cis rs12824058 0.549 rs4759453 chr12:130824565 C/G cg26677194 chr12:130822605 PIWIL1 0.43 6.91 0.36 2.44e-11 Menopause (age at onset); CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg04875709 chr12:12870463 CDKN1B 0.45 6.14 0.32 2.34e-9 Anxiety disorder; CRC cis rs2046867 0.862 rs75638790 chr3:72830502 C/T cg25664220 chr3:72788482 NA -0.46 -6.4 -0.33 5.37e-10 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; CRC cis rs449789 0.857 rs625284 chr6:159703373 G/T cg14500486 chr6:159655392 FNDC1 -0.48 -7.4 -0.38 1.13e-12 Pulse pressure; CRC cis rs1887596 0.639 rs11149445 chr13:27162727 A/G cg01312412 chr13:27282625 NA 0.43 5.66 0.3 3.29e-8 Facial morphology (factor 3, length of philtrum); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg21210124 chr9:92219187 GADD45G 0.43 6.03 0.32 4.51e-9 Response to antipsychotic treatment; CRC cis rs17666538 0.535 rs7822126 chr8:643810 A/G cg26554054 chr8:600488 NA 0.56 6.26 0.33 1.18e-9 IgG glycosylation; CRC cis rs172166 0.538 rs1150686 chr6:28161271 T/G cg06470822 chr6:28175283 NA 0.67 10.27 0.49 1.2e-21 Cardiac Troponin-T levels; CRC cis rs977987 0.736 rs4888392 chr16:75412262 T/C cg03315344 chr16:75512273 CHST6 0.53 8.85 0.44 5.48e-17 Dupuytren's disease; CRC cis rs10450586 0.863 rs6484283 chr11:27298776 C/G cg10370305 chr11:27303972 NA 0.38 6.23 0.32 1.42e-9 Total body bone mineral density; CRC cis rs3751196 0.808 rs12423889 chr12:104206092 G/A cg02344784 chr12:104178138 NT5DC3 0.7 7.16 0.37 5.43e-12 Sense of smell; CRC cis rs875971 0.895 rs4145009 chr7:65726615 T/C cg18876405 chr7:65276391 NA -0.49 -7.88 -0.4 4.88e-14 Aortic root size; CRC cis rs1129187 0.755 rs28868299 chr6:42921221 T/G cg26304593 chr6:42947056 PEX6 -0.44 -6.25 -0.33 1.26e-9 Alzheimer's disease in APOE e4+ carriers; CRC cis rs1348850 0.958 rs1545364 chr2:178462882 G/T cg02961200 chr2:178257176 LOC100130691;AGPS 0.52 7.51 0.38 5.6e-13 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs7255436 0.928 rs7250870 chr19:8453682 C/T cg16745616 chr19:8428856 ANGPTL4 -0.47 -7.58 -0.39 3.54e-13 HDL cholesterol; CRC cis rs637571 0.654 rs1058068 chr11:65667796 G/A cg04055107 chr11:65626734 MUS81;CFL1 0.51 7.03 0.36 1.21e-11 Eosinophil percentage of white cells; CRC trans rs6833159 0.527 rs10939231 chr4:28829372 A/T cg06994813 chr7:82792357 PCLO -0.39 -6.41 -0.33 4.92e-10 Underweight status; CRC trans rs7142881 0.508 rs7147510 chr14:32115400 G/C cg10453823 chr2:190539512 ANKAR 0.4 5.98 0.31 5.83e-9 Response to iloperidone treatment (QT prolongation); CRC cis rs3204270 0.639 rs62077183 chr17:79658940 C/A cg09655341 chr17:79618100 PDE6G 0.57 6.83 0.35 4.23e-11 Dental caries; CRC cis rs4665809 1.000 rs4665821 chr2:26309949 A/C cg04944784 chr2:26401820 FAM59B -0.6 -7.74 -0.39 1.24e-13 Gut microbiome composition (summer); CRC trans rs9388451 0.626 rs1343116 chr6:126069702 C/A cg05039488 chr6:79577232 IRAK1BP1 -0.74 -12.93 -0.58 3.26e-31 Brugada syndrome; CRC cis rs9322193 0.810 rs62439811 chr6:149961552 C/T cg13206674 chr6:150067644 NUP43 0.67 9.56 0.47 2.97e-19 Lung cancer; CRC cis rs1519814 0.956 rs4133251 chr8:121166993 A/G cg22335954 chr8:121166405 COL14A1 -0.59 -6.84 -0.35 3.81e-11 Breast cancer; CRC cis rs11785693 0.862 rs11774126 chr8:4979583 A/C cg26367366 chr8:4980734 NA 0.78 9.66 0.47 1.3e-19 Neuroticism (multi-trait analysis);Neuroticism; CRC cis rs13108904 0.967 rs12642396 chr4:1293055 C/A cg19318889 chr4:1322082 MAEA 0.41 5.73 0.3 2.28e-8 Obesity-related traits; CRC cis rs2739330 0.760 rs1002286 chr22:24257337 A/G cg09033563 chr22:24373618 LOC391322 0.43 6.32 0.33 8.69e-10 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs17376456 0.877 rs10514380 chr5:93409370 C/T cg09848695 chr5:92956644 FAM172A;MIR2277 0.64 6.26 0.33 1.22e-9 Diabetic retinopathy; CRC cis rs13108904 0.901 rs1316394 chr4:1315820 G/A cg02018176 chr4:1364513 KIAA1530 0.46 7.56 0.38 4.04e-13 Obesity-related traits; CRC cis rs116095464 0.558 rs7710005 chr5:233572 A/G cg22857025 chr5:266934 NA -1.25 -16.79 -0.68 3.81e-46 Breast cancer; CRC cis rs832540 0.931 rs702679 chr5:56221328 A/G cg18230493 chr5:56204884 C5orf35 -0.39 -5.89 -0.31 9.44e-9 Coronary artery disease; CRC cis rs875971 0.862 rs6460293 chr7:65810192 C/A cg18252515 chr7:66147081 NA 0.41 5.76 0.3 1.94e-8 Aortic root size; CRC trans rs9858542 1.000 rs11718165 chr3:49696797 A/G cg21665057 chr3:196295764 WDR53;FBXO45 -0.64 -8.43 -0.42 1.1e-15 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs13256369 0.802 rs1060107 chr8:8561399 G/T cg00074818 chr8:8560427 CLDN23 0.41 7.36 0.38 1.45e-12 Obesity-related traits; CRC cis rs1799949 1.000 rs4793212 chr17:41302750 T/C cg05368731 chr17:41323189 NBR1 0.65 9.59 0.47 2.27e-19 Menopause (age at onset); CRC cis rs720844 0.748 rs16828954 chr2:149330915 T/A cg09247360 chr2:149335327 NA -0.56 -6.04 -0.32 4.27e-9 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs9926296 0.715 rs2115401 chr16:89740609 A/G cg03605463 chr16:89740564 NA -0.57 -9.18 -0.45 5.08e-18 Vitiligo; CRC cis rs1552244 1.000 rs2272123 chr3:10140115 G/A cg08888203 chr3:10149979 C3orf24 0.73 10.15 0.49 3.03e-21 Alzheimer's disease; CRC cis rs9768139 0.611 rs12698211 chr7:158119623 G/A cg25566285 chr7:158114605 PTPRN2 0.47 7.5 0.38 6.01e-13 Calcium levels; CRC cis rs7429990 0.965 rs9854454 chr3:48012797 A/G cg11946769 chr3:48343235 NME6 -0.44 -5.72 -0.3 2.34e-8 Educational attainment (years of education); CRC cis rs8180040 0.701 rs34103310 chr3:47073266 C/T cg10298567 chr3:47292165 KIF9 -0.37 -5.91 -0.31 8.32e-9 Colorectal cancer; CRC cis rs13108904 0.901 rs13119532 chr4:1304505 G/C cg19318889 chr4:1322082 MAEA 0.4 5.71 0.3 2.55e-8 Obesity-related traits; CRC trans rs916888 0.773 rs199445 chr17:44817408 C/T cg01341218 chr17:43662625 NA 0.94 10.28 0.49 1.14e-21 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs929354 0.772 rs3802120 chr7:156977794 C/T cg05182265 chr7:156933206 UBE3C -0.76 -14.51 -0.62 3.13e-37 Body mass index; CRC cis rs1552244 0.572 rs17032426 chr3:10167112 G/A cg02579736 chr3:10068473 FANCD2;CIDECP 1.01 11.58 0.54 2.98e-26 Alzheimer's disease; CRC cis rs1528435 1.000 rs1406256 chr2:181528663 T/C cg23363182 chr2:181467187 NA -0.35 -5.68 -0.3 3e-8 Body mass index; CRC cis rs11212617 0.967 rs6589019 chr11:108324961 T/C cg14761454 chr11:108092087 ATM;NPAT 0.39 5.67 0.3 3.09e-8 Response to metformin in type 2 diabetes (glycemic); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg03428813 chr2:62115351 CCT4 0.5 7.01 0.36 1.34e-11 Response to antipsychotic treatment; CRC cis rs7264396 0.887 rs750487 chr20:34066645 T/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.38 -6.2 -0.32 1.68e-9 Total cholesterol levels; CRC cis rs4700695 0.841 rs251304 chr5:65249700 A/G cg21114390 chr5:65439923 SFRS12 0.57 6.88 0.35 3.05e-11 Facial morphology (factor 19); CRC trans rs944990 0.595 rs10123378 chr9:96375217 C/T cg10554839 chr10:27529782 ACBD5 0.42 6.54 0.34 2.29e-10 Body mass index; CRC cis rs6831352 0.918 rs29001194 chr4:100054844 A/G cg12011299 chr4:100065546 ADH4 -0.49 -9.27 -0.45 2.61e-18 Alcohol dependence; CRC cis rs10484885 0.878 rs72921937 chr6:90579863 T/G cg13799429 chr6:90582589 CASP8AP2 -0.72 -7.69 -0.39 1.76e-13 QRS interval (sulfonylurea treatment interaction); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg02276793 chr3:169685131 LOC100128164;SEC62 0.52 7.47 0.38 7.52e-13 Response to antipsychotic treatment; CRC cis rs7666738 0.678 rs7670805 chr4:99008763 A/G cg05340658 chr4:99064831 C4orf37 0.61 9.46 0.46 6.1e-19 Colonoscopy-negative controls vs population controls; CRC cis rs7811142 0.887 rs111972532 chr7:100069088 T/C cg00814883 chr7:100076585 TSC22D4 -0.78 -9.79 -0.47 5.01e-20 Platelet count; CRC cis rs7811142 1.000 rs11773661 chr7:100073069 G/C cg00814883 chr7:100076585 TSC22D4 -0.77 -9.6 -0.47 2.13e-19 Platelet count; CRC cis rs6951245 1.000 rs77346188 chr7:1114023 C/A cg22907277 chr7:1156413 C7orf50 0.76 8.07 0.41 1.31e-14 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs791888 0.965 rs791877 chr10:89406863 A/G cg13926569 chr10:89418898 PAPSS2 0.44 6.48 0.34 3.26e-10 Magnesium levels; CRC trans rs1455244 0.700 rs7229302 chr18:11508904 G/T cg10988288 chr7:150780510 TMUB1 0.39 6.24 0.33 1.34e-9 Schizophrenia; CRC cis rs801193 1.000 rs62466794 chr7:66191579 G/A cg18876405 chr7:65276391 NA 0.6 10.48 0.5 2.39e-22 Aortic root size; CRC cis rs60871478 1.000 rs4720917 chr7:806998 C/G cg13844804 chr7:814759 HEATR2 0.65 8.51 0.42 6.2e-16 Cerebrospinal P-tau181p levels; CRC cis rs72772090 0.539 rs17481856 chr5:96116808 G/A cg17330273 chr5:96107758 CAST;ERAP1 -0.64 -5.86 -0.31 1.12e-8 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs6502050 0.842 rs62079996 chr17:80076862 A/G cg02741985 chr17:80059408 CCDC57 -0.45 -7.4 -0.38 1.17e-12 Life satisfaction; CRC cis rs1059312 1.000 rs7135854 chr12:129279988 G/C cg09035930 chr12:129282057 SLC15A4 0.54 9.05 0.45 1.24e-17 Systemic lupus erythematosus; CRC cis rs7107356 1 rs7107356 chr11:47676170 A/G cg20307385 chr11:47447363 PSMC3 0.61 9.52 0.46 3.91e-19 Neuroticism;Neuroticism (multi-trait analysis); CRC cis rs6499255 0.951 rs2361838 chr16:69676086 T/C cg15192750 chr16:69999425 NA 0.56 7.54 0.38 4.63e-13 IgE levels; CRC cis rs3733585 0.699 rs12498956 chr4:9950705 G/T cg11266682 chr4:10021025 SLC2A9 -0.47 -9.53 -0.46 3.71e-19 Cleft plate (environmental tobacco smoke interaction); CRC cis rs1552244 1.000 rs722509 chr3:10102377 T/A cg16606324 chr3:10149918 C3orf24 0.72 9.82 0.48 3.92e-20 Alzheimer's disease; CRC cis rs644799 0.544 rs56298021 chr11:95545113 T/G cg25622487 chr11:95524042 FAM76B;CEP57 0.59 8.9 0.44 3.71e-17 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs35306767 0.855 rs55697724 chr10:885622 T/C cg26597838 chr10:835615 NA 1.28 14.87 0.63 1.28e-38 Eosinophil percentage of granulocytes; CRC cis rs7618915 0.547 rs10865973 chr3:52718154 A/T cg05573699 chr3:52720067 GNL3;PBRM1 -0.45 -6.32 -0.33 8.47e-10 Bipolar disorder; CRC cis rs875971 0.545 rs1638735 chr7:66095738 C/T cg03233332 chr7:66118400 NA -0.42 -5.66 -0.3 3.27e-8 Aortic root size; CRC cis rs9463078 0.764 rs3799971 chr6:44819319 G/C cg25276700 chr6:44698697 NA -0.27 -6.48 -0.34 3.43e-10 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; CRC trans rs7618501 1.000 rs7634902 chr3:49762662 G/T cg21665057 chr3:196295764 WDR53;FBXO45 -0.85 -15.74 -0.66 5.05e-42 Intelligence (multi-trait analysis); CRC trans rs564309 0.681 rs1150918 chr1:228608689 T/C cg20905516 chr11:106889364 GUCY1A2 0.58 6.11 0.32 2.8e-9 Hip circumference (psychosocial stress interaction); CRC cis rs9682041 0.696 rs10936626 chr3:170095019 G/A cg11886554 chr3:170076028 SKIL 0.69 8.29 0.42 3.01e-15 Glomerular filtration rate in non diabetics (creatinine);Glomerular filtration rate (creatinine); CRC cis rs9443645 0.810 rs9448607 chr6:79715620 G/A cg09184832 chr6:79620586 NA -0.47 -8.46 -0.42 8.66e-16 Intelligence (multi-trait analysis); CRC cis rs9976767 0.932 rs7283281 chr21:43825519 C/G cg23042151 chr21:43824109 UBASH3A -0.35 -6.31 -0.33 9.26e-10 Type 1 diabetes; CRC cis rs4888262 0.526 rs4887777 chr16:74637821 A/G cg01733217 chr16:74700730 RFWD3 0.8 12.1 0.56 3.83e-28 Testicular germ cell tumor; CRC cis rs9527 0.567 rs11191573 chr10:104896816 T/C cg15744005 chr10:104629667 AS3MT -0.31 -6.1 -0.32 3.03e-9 Arsenic metabolism; CRC cis rs9322193 0.962 rs35443312 chr6:149991761 T/C cg05861140 chr6:150128134 PCMT1 -0.42 -6.92 -0.36 2.32e-11 Lung cancer; CRC cis rs3087591 0.919 rs2953004 chr17:29502723 C/T cg24425628 chr17:29625626 OMG;NF1 0.79 13.32 0.59 1.13e-32 Hip circumference; CRC cis rs926938 0.520 rs4140445 chr1:115291978 T/C cg12756093 chr1:115239321 AMPD1 -0.66 -9.15 -0.45 6.14e-18 Autism; CRC cis rs6952808 0.691 rs2398709 chr7:2112548 C/T cg00106254 chr7:1943704 MAD1L1 -0.44 -6.14 -0.32 2.32e-9 Bipolar disorder and schizophrenia; CRC cis rs67311347 1.000 rs11707673 chr3:40450604 C/A cg24209194 chr3:40518798 ZNF619 0.41 5.74 0.3 2.11e-8 Renal cell carcinoma; CRC cis rs7044106 0.791 rs3904196 chr9:123480369 T/C cg09419670 chr9:123605666 PSMD5;LOC253039 0.75 12.19 0.56 1.79e-28 Hip circumference adjusted for BMI; CRC cis rs4819052 0.765 rs2838868 chr21:46714641 A/G cg02159808 chr21:46707872 POFUT2;LOC642852 -0.55 -6.57 -0.34 2.01e-10 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs6951245 1.000 rs74785791 chr7:1088494 T/C cg24642844 chr7:1081250 C7orf50 -0.79 -9.35 -0.46 1.4e-18 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs7772486 0.764 rs7745696 chr6:146162829 T/C cg23711669 chr6:146136114 FBXO30 0.69 11.68 0.54 1.36e-26 Lobe attachment (rater-scored or self-reported); CRC cis rs6500395 0.735 rs7204345 chr16:48666726 T/C cg04672837 chr16:48644449 N4BP1 0.43 6.38 0.33 6.13e-10 Response to tocilizumab in rheumatoid arthritis; CRC cis rs881375 0.967 rs7046108 chr9:123660339 A/G cg14255062 chr9:123606675 PSMD5;LOC253039 -0.4 -5.69 -0.3 2.74e-8 Rheumatoid arthritis; CRC trans rs475616 0.917 rs866919 chr10:30513283 C/T cg24192786 chr5:122917781 CSNK1G3 0.4 6.04 0.32 4.17e-9 Monocyte count; CRC cis rs2303759 0.918 rs4802597 chr19:49872085 C/T cg22590775 chr19:49891494 CCDC155 0.57 8.23 0.41 4.34e-15 Multiple sclerosis; CRC cis rs7107174 1.000 rs2511168 chr11:77965081 T/G cg02023728 chr11:77925099 USP35 0.52 7.95 0.4 2.98e-14 Testicular germ cell tumor; CRC cis rs1862618 0.671 rs2591964 chr5:56236900 T/G cg18230493 chr5:56204884 C5orf35 0.59 8.69 0.43 1.69e-16 Initial pursuit acceleration; CRC cis rs4604732 0.631 rs34924545 chr1:247626892 G/T cg12754571 chr1:247694271 LOC148824;OR2C3 0.42 5.83 0.31 1.36e-8 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CRC cis rs7940866 0.801 rs10894288 chr11:130808679 T/C cg12179176 chr11:130786555 SNX19 0.65 9.5 0.46 4.63e-19 Schizophrenia; CRC cis rs9914988 0.832 rs34267753 chr17:27157586 T/C cg07195577 chr17:27052828 TLCD1 0.41 5.92 0.31 7.89e-9 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs17818399 0.547 rs7607308 chr2:46759104 T/C cg21681030 chr2:46777652 RHOQ 0.42 5.71 0.3 2.52e-8 Height; CRC cis rs875971 1.000 rs6970030 chr7:65968679 T/C cg00343986 chr7:65444356 GUSB 0.44 6.47 0.34 3.56e-10 Aortic root size; CRC cis rs8105895 0.935 rs10413784 chr19:22246191 A/G cg02657401 chr19:22469223 NA -0.34 -5.65 -0.3 3.56e-8 Body mass index (change over time); CRC trans rs7824557 0.527 rs57629785 chr8:11235150 C/A cg06636001 chr8:8085503 FLJ10661 -0.45 -6.79 -0.35 5.15e-11 Retinal vascular caliber; CRC cis rs317689 0.680 rs315140 chr12:69790780 A/T cg20891283 chr12:69753455 YEATS4 0.63 8.06 0.41 1.4e-14 Response to diuretic therapy; CRC cis rs6748734 1.000 rs4675868 chr2:241828542 A/C cg04034577 chr2:241836375 C2orf54 -0.42 -8.97 -0.44 2.25e-17 Urinary metabolites; CRC cis rs9534288 0.957 rs2404731 chr13:46618384 T/C cg15192986 chr13:46630673 CPB2 -0.74 -10.35 -0.5 6.36e-22 Blood protein levels; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg05617927 chr15:83654886 FAM103A1 0.52 6.66 0.34 1.14e-10 Thyroid stimulating hormone; CRC cis rs9549328 0.670 rs2993344 chr13:113617022 C/T cg17524180 chr13:113633600 MCF2L 0.52 9.51 0.46 4.12e-19 Systolic blood pressure; CRC cis rs6831352 0.918 rs29001194 chr4:100054844 A/G cg13256891 chr4:100009986 ADH5 -0.66 -8.89 -0.44 4.04e-17 Alcohol dependence; CRC cis rs3617 0.573 rs9880978 chr3:52923251 C/G cg11645453 chr3:52864694 ITIH4 0.4 7.85 0.4 6.03e-14 Red blood cell count;Autism spectrum disorder or schizophrenia; CRC cis rs3857067 1.000 rs1585652 chr4:95014313 A/G cg11021082 chr4:95130006 SMARCAD1 -0.4 -6.05 -0.32 3.9e-9 QT interval; CRC cis rs7666738 0.830 rs9998803 chr4:99002519 C/T cg05340658 chr4:99064831 C4orf37 0.61 9.54 0.47 3.44e-19 Colonoscopy-negative controls vs population controls; CRC cis rs6942756 0.747 rs691435 chr7:129097352 C/T cg02491457 chr7:128862824 NA 0.6 8.13 0.41 8.56e-15 White matter hyperintensity burden; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg05800723 chr4:79103126 FRAS1 0.48 8.14 0.41 8.53e-15 Liver disease severity in Alagille syndrome; CRC trans rs4824093 0.610 rs58671506 chr22:50288983 G/A cg09872104 chr7:134855509 C7orf49 -0.82 -7.2 -0.37 4e-12 Amyotrophic lateral sclerosis (sporadic); CRC cis rs6500602 0.727 rs2160567 chr16:4535557 C/T cg08645402 chr16:4508243 NA 0.61 11.04 0.52 2.59e-24 Schizophrenia; CRC cis rs7918232 1.000 rs7918232 chr10:27369162 A/G cg14442939 chr10:27389572 ANKRD26 0.79 9.04 0.45 1.33e-17 Breast cancer; CRC cis rs887829 0.507 rs10929301 chr2:234663649 C/G cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.46 -7.16 -0.37 5.36e-12 Metabolic traits;Bilirubin levels;Cholelithiasis-related traits in sickle cell anemia;Metabolite levels;Total bilirubin levels in HIV-1 infection;Serum metabolite levels;Blood metabolite levels; CRC cis rs10504229 0.654 rs903705 chr8:58128185 T/A cg02290350 chr8:58132656 NA -0.58 -8.16 -0.41 7.29e-15 Developmental language disorder (linguistic errors); CRC cis rs4660306 0.744 rs11211114 chr1:45926243 G/C cg03123370 chr1:45965343 CCDC163P;MMACHC 0.53 7.02 0.36 1.26e-11 Homocysteine levels; CRC trans rs9329221 0.905 rs4841329 chr8:10253098 A/G cg16141378 chr3:129829833 LOC729375 0.43 6.43 0.33 4.6e-10 Neuroticism; CRC cis rs763121 0.853 rs5757196 chr22:39039855 G/C cg06544989 chr22:39130855 UNC84B 0.44 6.84 0.35 3.76e-11 Menopause (age at onset); CRC cis rs9527 0.590 rs6584537 chr10:104778267 C/G cg15744005 chr10:104629667 AS3MT -0.3 -5.95 -0.31 6.96e-9 Arsenic metabolism; CRC cis rs3126085 0.935 rs1496050 chr1:152163549 T/C cg09127314 chr1:152161683 NA 0.49 6.18 0.32 1.88e-9 Atopic dermatitis; CRC cis rs651907 0.557 rs34457525 chr3:101435225 C/T cg12386194 chr3:101231763 SENP7 0.49 7.21 0.37 3.99e-12 Colorectal cancer; CRC cis rs710216 0.536 rs710222 chr1:43413653 A/G cg03128534 chr1:43423976 SLC2A1 0.55 8.26 0.41 3.56e-15 Red cell distribution width; CRC cis rs17376456 0.825 rs10057130 chr5:93282557 C/T cg21475434 chr5:93447410 FAM172A 0.82 7.84 0.4 6.37e-14 Diabetic retinopathy; CRC cis rs826838 0.834 rs826874 chr12:39122599 C/A cg26384229 chr12:38710491 ALG10B -0.54 -7.84 -0.4 6.33e-14 Heart rate; CRC cis rs4242434 0.927 rs10095121 chr8:22538426 A/G cg03733263 chr8:22462867 KIAA1967 0.85 12.68 0.57 2.82e-30 Exploratory eye movement dysfunction in schizophrenia (cognitive search score); CRC cis rs4975709 0.589 rs931508 chr5:1861224 C/G cg15595755 chr5:1867978 NA 0.37 6.21 0.32 1.56e-9 Cardiovascular disease risk factors; CRC cis rs4665809 1.000 rs1470097 chr2:26312840 A/G cg26119090 chr2:26468346 HADHA;HADHB -0.6 -7.89 -0.4 4.37e-14 Gut microbiome composition (summer); CRC cis rs1552244 1.000 rs6793396 chr3:10110927 T/C cg18598329 chr3:10140678 FANCD2;C3orf24 -0.87 -11.82 -0.55 4.24e-27 Alzheimer's disease; CRC cis rs10504229 0.679 rs6995378 chr8:58113933 C/T cg04204079 chr8:58130323 NA -0.45 -5.84 -0.31 1.27e-8 Developmental language disorder (linguistic errors); CRC cis rs6496667 1.000 rs7162175 chr15:90897473 A/G cg04176472 chr15:90893244 GABARAPL3 0.61 8.47 0.42 8.02e-16 Rheumatoid arthritis; CRC cis rs6963495 0.818 rs818621 chr7:105173029 T/C cg02135003 chr7:105160482 PUS7 -0.68 -10.13 -0.49 3.59e-21 Bipolar disorder (body mass index interaction); CRC cis rs1799949 1.000 rs35668327 chr17:41273095 G/A cg23758822 chr17:41437982 NA 0.79 13.38 0.59 6.71e-33 Menopause (age at onset); CRC cis rs2243480 1.000 rs7792391 chr7:65773429 A/G cg12463550 chr7:65579703 CRCP -0.69 -6.18 -0.32 1.85e-9 Diabetic kidney disease; CRC cis rs60871478 0.636 rs7792072 chr7:886239 C/T cg13798912 chr7:905769 UNC84A -0.63 -6.96 -0.36 1.9e-11 Cerebrospinal P-tau181p levels; CRC cis rs2019137 0.560 rs6707386 chr2:113981022 G/A cg02675527 chr2:114030824 PAX8;LOC440839 -0.42 -6.17 -0.32 1.96e-9 Lymphocyte counts; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg07970400 chr15:40650285 DISP2 0.42 6.8 0.35 5.08e-11 Liver disease severity in Alagille syndrome; CRC cis rs8067545 1.000 rs28807825 chr17:19942850 G/A cg13482628 chr17:19912719 NA 0.54 8.59 0.43 3.6e-16 Schizophrenia; CRC cis rs7586879 0.616 rs6545814 chr2:25131316 A/G cg22495460 chr2:25135724 ADCY3 -0.88 -17.4 -0.69 1.56e-48 Body mass index; CRC cis rs2836974 0.644 rs61300849 chr21:40680194 G/A cg06238570 chr21:40685208 BRWD1 -0.82 -13.06 -0.58 1.11e-31 Cognitive function; CRC cis rs60871478 1.000 rs62432899 chr7:826542 G/C cg13844804 chr7:814759 HEATR2 0.68 8.0 0.4 2.15e-14 Cerebrospinal P-tau181p levels; CRC cis rs9611565 0.765 rs132915 chr22:41805782 T/C cg06481639 chr22:41940642 POLR3H 0.51 5.89 0.31 9.38e-9 Vitiligo; CRC cis rs2882667 0.690 rs160401 chr5:138061341 C/T cg09476006 chr5:138032270 NA -0.53 -9.04 -0.45 1.33e-17 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs56104184 1.000 rs56104184 chr19:49370310 C/T cg15549821 chr19:49342101 PLEKHA4 -0.6 -7.51 -0.38 5.57e-13 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; CRC cis rs9894429 0.546 rs9906979 chr17:79608765 A/G cg18240062 chr17:79603768 NPLOC4 0.57 9.64 0.47 1.54e-19 Eye color traits; CRC cis rs4713118 0.586 rs6905516 chr6:28086478 A/G cg15786705 chr6:28176104 NA 0.76 9.47 0.46 5.57e-19 Parkinson's disease; CRC cis rs929354 1.000 rs1182413 chr7:157058557 G/A cg05182265 chr7:156933206 UBE3C 0.67 12.3 0.56 7.37e-29 Body mass index; CRC cis rs7618501 1.000 rs34451146 chr3:49813013 C/T cg24308560 chr3:49941425 MST1R -0.45 -7.01 -0.36 1.33e-11 Intelligence (multi-trait analysis); CRC cis rs4713118 0.662 rs469228 chr6:27970704 A/G cg02683197 chr6:28174875 NA 0.65 9.03 0.45 1.48e-17 Parkinson's disease; CRC cis rs9467711 0.606 rs9393708 chr6:26362643 C/T cg16898833 chr6:26189333 HIST1H4D -0.73 -6.21 -0.32 1.56e-9 Autism spectrum disorder or schizophrenia; CRC cis rs6952808 0.693 rs10950413 chr7:1912988 A/G cg02951883 chr7:2050386 MAD1L1 -0.59 -9.86 -0.48 2.86e-20 Bipolar disorder and schizophrenia; CRC cis rs7412746 0.658 rs6657388 chr1:150748786 A/G cg10589385 chr1:150898437 SETDB1 0.31 6.34 0.33 7.79e-10 Melanoma; CRC cis rs7591163 1.000 rs1039665 chr2:228717392 A/G cg22079747 chr2:228736145 WDR69 -0.44 -5.91 -0.31 8.76e-9 Blood pressure; CRC cis rs11958404 0.932 rs61478293 chr5:157426299 G/A cg05962755 chr5:157440814 NA 0.79 10.82 0.51 1.57e-23 IgG glycosylation; CRC cis rs9462027 0.628 rs9469914 chr6:34827693 A/T cg07306190 chr6:34760872 UHRF1BP1 -0.34 -6.19 -0.32 1.82e-9 Systemic lupus erythematosus; CRC cis rs7666738 0.830 rs10001701 chr4:98918871 G/C cg17366294 chr4:99064904 C4orf37 0.41 6.82 0.35 4.46e-11 Colonoscopy-negative controls vs population controls; CRC cis rs2836950 0.520 rs8133927 chr21:40689961 G/T cg11644478 chr21:40555479 PSMG1 -0.44 -6.53 -0.34 2.56e-10 Menarche (age at onset); CRC cis rs8177253 0.829 rs6794945 chr3:133518463 A/G cg12373951 chr3:133503437 NA -0.26 -6.43 -0.33 4.38e-10 Iron status biomarkers; CRC trans rs7618501 1.000 rs7372730 chr3:49790682 C/G cg21665057 chr3:196295764 WDR53;FBXO45 -0.86 -15.73 -0.66 5.59e-42 Intelligence (multi-trait analysis); CRC cis rs1348850 0.567 rs3821006 chr2:178537694 G/A cg02961200 chr2:178257176 LOC100130691;AGPS 0.59 8.38 0.42 1.6e-15 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC trans rs9291683 0.655 rs35750364 chr4:10049049 T/C cg26043149 chr18:55253948 FECH 0.53 8.27 0.41 3.26e-15 Bone mineral density; CRC cis rs11098499 0.605 rs6833140 chr4:120266822 G/A cg09307838 chr4:120376055 NA 0.62 9.69 0.47 1.07e-19 Corneal astigmatism; CRC cis rs10540 0.686 rs12421266 chr11:537120 C/T cg03352830 chr11:487213 PTDSS2 0.65 7.33 0.37 1.75e-12 Body mass index; CRC cis rs763121 0.651 rs738249 chr22:39037979 T/C cg06544989 chr22:39130855 UNC84B 0.44 6.62 0.34 1.44e-10 Menopause (age at onset); CRC cis rs11098499 0.754 rs878372 chr4:120238780 A/C cg09307838 chr4:120376055 NA 0.62 9.75 0.47 6.92e-20 Corneal astigmatism; CRC cis rs977987 0.735 rs166013 chr16:75434146 C/T cg03315344 chr16:75512273 CHST6 -0.57 -9.23 -0.45 3.35e-18 Dupuytren's disease; CRC trans rs1005277 0.505 rs200939 chr10:38139483 T/C cg23533926 chr12:111358616 MYL2 -0.43 -6.44 -0.33 4.18e-10 Extrinsic epigenetic age acceleration; CRC cis rs7727544 0.836 rs10463892 chr5:131598705 T/C cg12564285 chr5:131593104 PDLIM4 0.38 7.44 0.38 8.85e-13 Blood metabolite levels; CRC cis rs1862618 0.641 rs2591954 chr5:56245044 G/C cg18230493 chr5:56204884 C5orf35 0.6 8.95 0.44 2.64e-17 Initial pursuit acceleration; CRC cis rs912057 0.526 rs201061 chr6:6730512 C/T cg06612196 chr6:6737390 NA -0.63 -10.53 -0.5 1.53e-22 Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction); CRC cis rs67311347 1.000 rs7636719 chr3:40432084 C/T cg09455208 chr3:40491958 NA 0.44 8.95 0.44 2.58e-17 Renal cell carcinoma; CRC cis rs9807989 0.507 rs4851577 chr2:103028921 T/C cg03938978 chr2:103052716 IL18RAP 0.59 10.13 0.49 3.5e-21 Asthma; CRC cis rs9858542 0.953 rs9821311 chr3:49543656 C/T cg00383909 chr3:49044727 WDR6 0.44 5.68 0.3 2.91e-8 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs853679 0.550 rs6901017 chr6:28152583 T/C cg12172441 chr6:28176163 NA 0.67 8.41 0.42 1.25e-15 Depression; CRC cis rs9487051 0.714 rs6903695 chr6:109631422 C/G cg01475377 chr6:109611718 NA 0.36 6.41 0.33 5.02e-10 Reticulocyte fraction of red cells; CRC cis rs853679 0.517 rs9393901 chr6:28136797 A/G cg03623178 chr6:28175578 NA 0.98 12.66 0.57 3.31e-30 Depression; CRC cis rs1448094 0.967 rs2121892 chr12:86324556 G/T cg18827107 chr12:86230957 RASSF9 -0.37 -6.1 -0.32 2.98e-9 Major depressive disorder; CRC cis rs728616 0.867 rs56000427 chr10:81986946 A/G cg05935833 chr10:81318306 SFTPA2 -0.79 -8.12 -0.41 9.2e-15 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs6502050 0.731 rs12150589 chr17:80158233 A/T cg13198984 chr17:80129470 CCDC57 0.42 7.33 0.37 1.77e-12 Life satisfaction; CRC cis rs9916302 0.861 rs33933929 chr17:37426441 A/C cg15445000 chr17:37608096 MED1 0.42 9.06 0.45 1.23e-17 Glomerular filtration rate (creatinine); CRC cis rs9926296 0.607 rs2079672 chr16:89884917 A/G cg04287289 chr16:89883240 FANCA -0.67 -11.45 -0.53 9.28e-26 Vitiligo; CRC cis rs3617 0.625 rs2245647 chr3:52862753 A/G cg11645453 chr3:52864694 ITIH4 0.46 9.25 0.45 2.91e-18 Red blood cell count;Autism spectrum disorder or schizophrenia; CRC cis rs951366 0.764 rs708724 chr1:205743663 A/C cg07157834 chr1:205819609 PM20D1 0.78 12.0 0.55 9.33e-28 Menarche (age at onset); CRC cis rs6499255 1.000 rs4985518 chr16:69787158 T/C cg00738113 chr16:70207722 CLEC18C -0.41 -5.93 -0.31 7.84e-9 IgE levels; CRC trans rs783540 0.846 rs783539 chr15:83254070 A/C cg18393722 chr15:85113863 UBE2QP1 -0.36 -6.14 -0.32 2.31e-9 Schizophrenia; CRC cis rs12893668 0.572 rs12590968 chr14:104136633 G/C cg08213375 chr14:104286397 PPP1R13B 0.43 6.83 0.35 4.21e-11 Reticulocyte count; CRC cis rs7703744 0.634 rs6883657 chr5:118683346 C/G cg02283238 chr5:118691126 TNFAIP8 0.46 6.2 0.32 1.67e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs734999 0.588 rs3748818 chr1:2525660 G/A cg18854424 chr1:2615690 NA 0.4 7.6 0.39 3.18e-13 Ulcerative colitis; CRC cis rs7945718 0.806 rs7480572 chr11:12787048 T/C cg25843174 chr11:12811716 TEAD1 0.47 9.03 0.45 1.52e-17 Educational attainment (years of education); CRC cis rs908922 0.676 rs7545336 chr1:152527863 A/G cg09873164 chr1:152488093 CRCT1 0.36 6.13 0.32 2.48e-9 Hair morphology; CRC cis rs478304 0.934 rs498354 chr11:65528213 A/G cg27068330 chr11:65405492 SIPA1 0.48 7.0 0.36 1.45e-11 Acne (severe); CRC cis rs4973397 0.883 rs4973392 chr2:232286552 G/A cg13347044 chr2:232276743 NA 0.52 7.12 0.37 6.82e-12 Anti-saccade response; CRC cis rs4731207 0.698 rs7796015 chr7:124521146 C/T cg23710748 chr7:124431027 NA -0.38 -6.1 -0.32 2.96e-9 Cutaneous malignant melanoma; CRC cis rs7605827 0.930 rs13002869 chr2:15674389 C/T cg19274914 chr2:15703543 NA 0.39 5.87 0.31 1.07e-8 Educational attainment (years of education); CRC cis rs6701037 0.566 rs10753091 chr1:175134571 T/C cg00321850 chr1:175162397 KIAA0040 0.45 7.54 0.38 4.47e-13 Alcohol dependence; CRC cis rs6921919 0.515 rs1339898 chr6:28395506 C/T cg06470822 chr6:28175283 NA 0.42 5.72 0.3 2.42e-8 Autism spectrum disorder or schizophrenia; CRC cis rs8060686 0.546 rs7188350 chr16:68149316 T/C cg26727032 chr16:67993705 SLC12A4 -0.62 -9.37 -0.46 1.21e-18 HDL cholesterol;Metabolic syndrome; CRC cis rs1801251 1.000 rs12474040 chr2:233615345 T/G cg25237894 chr2:233734115 C2orf82 0.54 8.76 0.44 1.03e-16 Coronary artery disease; CRC cis rs10504229 0.906 rs17805439 chr8:58172400 T/C cg05313129 chr8:58192883 C8orf71 -0.47 -6.99 -0.36 1.49e-11 Developmental language disorder (linguistic errors); CRC cis rs9611565 0.625 rs2076199 chr22:41903743 G/T cg06634786 chr22:41940651 POLR3H -0.43 -5.61 -0.3 4.36e-8 Vitiligo; CRC cis rs11148252 0.904 rs7990581 chr13:53019433 A/G cg12458913 chr13:53173898 NA 0.58 9.27 0.46 2.54e-18 Lewy body disease; CRC cis rs2836950 0.501 rs4818018 chr21:40694072 C/T cg11644478 chr21:40555479 PSMG1 -0.44 -6.49 -0.34 3.07e-10 Menarche (age at onset); CRC cis rs1865760 0.532 rs1061482 chr6:26086699 G/T cg17691542 chr6:26056736 HIST1H1C 0.56 8.49 0.42 6.97e-16 Height; CRC cis rs4665809 1.000 rs7599132 chr2:26279810 A/T cg26119090 chr2:26468346 HADHA;HADHB 0.59 7.61 0.39 2.95e-13 Gut microbiome composition (summer); CRC cis rs972578 1.000 rs972577 chr22:43387645 C/T cg01576275 chr22:43409880 NA -0.49 -7.76 -0.39 1.06e-13 Mean platelet volume; CRC cis rs1862618 0.802 rs194058 chr5:56188977 G/A cg22800045 chr5:56110881 MAP3K1 0.6 6.38 0.33 5.99e-10 Initial pursuit acceleration; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg12564526 chr7:66767603 PMS2L4;STAG3L4 0.54 9.24 0.45 3.11e-18 Liver disease severity in Alagille syndrome; CRC cis rs748404 0.560 rs1060939 chr15:43816917 C/T cg02155558 chr15:43621948 ADAL;LCMT2 0.52 7.32 0.37 1.92e-12 Lung cancer; CRC cis rs6951245 1.000 rs76129108 chr7:1089159 G/A cg04025307 chr7:1156635 C7orf50 0.64 6.66 0.34 1.16e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs13392177 0.684 rs11695527 chr2:219068103 A/G cg04731861 chr2:219085781 ARPC2 -0.33 -6.77 -0.35 5.85e-11 Pyoderma gangrenosum in inflammatory bowel disease; CRC trans rs6011368 0.765 rs7270745 chr20:62892756 C/G cg13869341 chr1:15865 WASH5P -0.4 -6.05 -0.32 3.84e-9 Clozapine-induced cytotoxicity; CRC cis rs950027 0.620 rs1153860 chr15:45636584 A/G cg10760299 chr15:45669010 GATM -0.38 -6.06 -0.32 3.63e-9 Response to fenofibrate (adiponectin levels); CRC trans rs56176327 0.600 rs7628207 chr3:49754970 T/C cg21665057 chr3:196295764 WDR53;FBXO45 -0.61 -6.87 -0.35 3.25e-11 Intelligence (multi-trait analysis); CRC cis rs317689 0.581 rs160829 chr12:69769538 G/C cg19645103 chr12:69753606 YEATS4 -0.43 -5.63 -0.3 3.77e-8 Response to diuretic therapy; CRC cis rs6598955 0.670 rs10902734 chr1:26617923 G/T cg00852783 chr1:26633632 UBXN11 -0.44 -7.13 -0.37 6.54e-12 Obesity-related traits; CRC trans rs7027930 0.524 rs3812527 chr9:608683 A/C cg27061366 chr19:13044373 FARSA 0.48 6.07 0.32 3.45e-9 Pulmonary function decline; CRC cis rs3768617 0.811 rs12138049 chr1:182979546 C/T ch.1.3577855R chr1:183094577 LAMC1 0.61 8.98 0.44 2.15e-17 Fuchs's corneal dystrophy; CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg06666157 chr19:4791552 FEM1A -0.56 -6.9 -0.36 2.68e-11 Diisocyanate-induced asthma; CRC cis rs8105895 0.935 rs10411275 chr19:22259469 A/G cg02657401 chr19:22469223 NA -0.34 -5.65 -0.3 3.56e-8 Body mass index (change over time); CRC cis rs1577917 0.876 rs1582127 chr6:86697204 C/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.51 -6.77 -0.35 5.76e-11 Response to antipsychotic treatment; CRC cis rs1448094 0.511 rs61930579 chr12:86157044 G/A cg18827107 chr12:86230957 RASSF9 -0.41 -6.18 -0.32 1.89e-9 Major depressive disorder; CRC cis rs2658782 1.000 rs2019814 chr11:93168885 A/G cg15737290 chr11:93063684 CCDC67 0.54 7.54 0.38 4.64e-13 Pulmonary function decline; CRC trans rs7937682 0.921 rs34584980 chr11:111441537 G/A cg18187862 chr3:45730750 SACM1L -0.53 -6.87 -0.35 3.25e-11 Primary sclerosing cholangitis; CRC cis rs1862618 0.853 rs2548664 chr5:56133555 G/A cg24531977 chr5:56204891 C5orf35 -0.81 -10.94 -0.52 5.99e-24 Initial pursuit acceleration; CRC cis rs2811415 0.597 rs9882664 chr3:127766058 A/C cg13719885 chr3:127795394 NA 0.4 6.02 0.31 4.69e-9 Lung function (FEV1/FVC); CRC cis rs3087591 0.887 rs2905875 chr17:29541339 A/T cg24425628 chr17:29625626 OMG;NF1 0.78 14.34 0.62 1.47e-36 Hip circumference; CRC cis rs4588572 0.688 rs2115436 chr5:77692617 A/T cg11547950 chr5:77652471 NA -0.5 -7.41 -0.38 1.05e-12 Triglycerides; CRC cis rs6804368 0.553 rs9839109 chr3:30770605 C/T cg06106510 chr3:30762233 NA -0.37 -6.05 -0.32 4.04e-9 Blood metabolite levels; CRC trans rs116095464 0.558 rs6875291 chr5:264192 T/C cg00938859 chr5:1591904 SDHAP3 0.73 7.89 0.4 4.53e-14 Breast cancer; CRC cis rs250677 0.687 rs250667 chr5:148455134 A/G cg23229984 chr5:148520753 ABLIM3 -0.47 -6.5 -0.34 2.93e-10 Breast cancer; CRC cis rs10504229 0.683 rs16921814 chr8:58107421 A/T cg21724239 chr8:58056113 NA 0.57 7.63 0.39 2.49e-13 Developmental language disorder (linguistic errors); CRC cis rs11971779 0.680 rs6467843 chr7:139070523 A/G cg07862535 chr7:139043722 LUC7L2 0.57 7.35 0.38 1.61e-12 Diisocyanate-induced asthma; CRC cis rs10751667 0.666 rs4074235 chr11:977511 C/G cg23136738 chr11:925521 AP2A2 -0.42 -7.09 -0.36 8.19e-12 Alzheimer's disease (late onset); CRC cis rs7503807 0.515 rs12944407 chr17:78691979 C/T cg00549398 chr17:78725201 RPTOR 0.43 5.7 0.3 2.72e-8 Obesity; CRC cis rs8077889 0.917 rs28694735 chr17:41912144 A/G cg26893861 chr17:41843967 DUSP3 0.87 11.62 0.54 2.24e-26 Triglycerides; CRC cis rs2836974 0.568 rs419469 chr21:40537234 C/T cg11890956 chr21:40555474 PSMG1 0.91 16.17 0.67 1.13e-43 Cognitive function; CRC cis rs9291683 0.620 rs4383618 chr4:10125151 T/C cg00071950 chr4:10020882 SLC2A9 -0.48 -8.17 -0.41 6.83e-15 Bone mineral density; CRC cis rs35110281 0.776 rs2838316 chr21:44990036 C/T cg01579765 chr21:45077557 HSF2BP -0.38 -7.45 -0.38 8.12e-13 Mean corpuscular volume; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg00995911 chr19:45004602 ZNF180 0.39 6.18 0.32 1.92e-9 Liver disease severity in Alagille syndrome; CRC cis rs853679 1.000 rs853685 chr6:28288785 C/T cg21251018 chr6:28226885 NKAPL 0.5 5.8 0.3 1.56e-8 Depression; CRC trans rs4915077 0.773 rs12564672 chr1:108287028 A/T cg00331283 chr11:133917072 NA -0.54 -6.07 -0.32 3.52e-9 Hypothyroidism; CRC cis rs6860806 0.507 rs272878 chr5:131671769 C/T cg27615366 chr5:131592974 PDLIM4 -0.34 -6.23 -0.33 1.39e-9 Breast cancer; CRC cis rs11122272 0.766 rs2739511 chr1:231526490 G/C cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.56 -8.56 -0.43 4.41e-16 Hemoglobin concentration; CRC trans rs4650994 1.000 rs35810840 chr1:178522642 G/A cg05059571 chr16:84539110 KIAA1609 -0.45 -6.84 -0.35 3.82e-11 HDL cholesterol levels;HDL cholesterol; CRC cis rs9826463 0.757 rs79576118 chr3:142244645 A/C cg20824294 chr3:142316082 PLS1 0.4 6.69 0.35 9.6e-11 QRS duration in Tripanosoma cruzi seropositivity; CRC cis rs853679 0.599 rs188015 chr6:27877446 T/A cg15845792 chr6:28175446 NA 0.76 6.85 0.35 3.65e-11 Depression; CRC cis rs10504229 1.000 rs72650887 chr8:58177343 G/A cg22535103 chr8:58192502 C8orf71 -0.82 -12.31 -0.56 6.46e-29 Developmental language disorder (linguistic errors); CRC cis rs10256972 0.591 rs11766651 chr7:1161646 A/G cg23708337 chr7:1209742 NA 0.47 6.98 0.36 1.59e-11 Longevity;Endometriosis; CRC cis rs7523050 0.643 rs17563938 chr1:109401654 C/T cg08274380 chr1:109419600 GPSM2 0.85 6.65 0.34 1.24e-10 Fat distribution (HIV); CRC cis rs7542091 0.748 rs2357231 chr1:210028454 A/C cg05527609 chr1:210001259 C1orf107 0.58 8.08 0.41 1.26e-14 Monobrow; CRC cis rs12541335 0.639 rs11135995 chr8:22200148 C/T cg18135555 chr8:22132992 PIWIL2 -0.37 -7.19 -0.37 4.37e-12 Hypertriglyceridemia; CRC cis rs6424115 0.830 rs6680132 chr1:24198804 T/C cg09473613 chr1:24152604 HMGCL 0.34 5.63 0.3 3.83e-8 Immature fraction of reticulocytes; CRC cis rs9914988 0.778 rs35398767 chr17:27122960 A/T cg16670446 chr17:27188758 MIR451;MIR144 0.55 8.52 0.43 5.75e-16 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs7274811 0.652 rs291686 chr20:32010851 T/C cg03904042 chr20:32255491 NECAB3;C20orf134 0.42 6.02 0.32 4.56e-9 Height; CRC cis rs60871478 0.838 rs12530859 chr7:835034 G/A cg13844804 chr7:814759 HEATR2 -0.65 -7.35 -0.38 1.59e-12 Cerebrospinal P-tau181p levels; CRC cis rs9796 0.621 rs12324159 chr15:41462468 G/A cg18705301 chr15:41695430 NDUFAF1 -0.41 -6.72 -0.35 8.03e-11 Menopause (age at onset); CRC cis rs17376456 0.825 rs28645862 chr5:93233128 G/C cg09848695 chr5:92956644 FAM172A;MIR2277 0.66 5.98 0.31 5.9e-9 Diabetic retinopathy; CRC cis rs2842992 0.709 rs1853257 chr6:160212710 C/G cg19482086 chr6:160211437 TCP1;MRPL18 0.73 9.67 0.47 1.21e-19 Age-related macular degeneration (geographic atrophy); CRC cis rs6558530 0.692 rs6558522 chr8:1702370 C/G cg19131313 chr8:1704013 NA 0.5 6.3 0.33 9.38e-10 Systolic blood pressure; CRC cis rs881375 0.900 rs2241003 chr9:123666777 G/C cg09586646 chr9:123605570 PSMD5;LOC253039 0.44 6.22 0.32 1.49e-9 Rheumatoid arthritis; CRC cis rs1218582 0.772 rs4845694 chr1:154911651 C/G cg24250549 chr1:154909240 PMVK 0.64 10.92 0.52 6.61e-24 Prostate cancer; CRC trans rs9291683 0.669 rs887733 chr4:10183108 T/C cg26043149 chr18:55253948 FECH -0.54 -8.2 -0.41 5.38e-15 Bone mineral density; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg21117584 chr1:38019997 SNIP1 0.41 5.97 0.31 6e-9 Intelligence (multi-trait analysis); CRC cis rs13064411 0.866 rs35278902 chr3:113239021 A/G cg18753928 chr3:113234510 CCDC52 -0.58 -6.76 -0.35 6.18e-11 Response to simvastatin treatment (PCSK9 protein level change); CRC trans rs10237067 0.581 rs10271980 chr7:68345599 A/G cg25628286 chr3:111396827 PLCXD2 0.38 5.98 0.31 5.73e-9 Lifetime average cigarettes per day in chronic obstructive pulmonary disease; CRC cis rs853679 0.517 rs9393893 chr6:28109262 T/C cg02631126 chr6:28058918 ZSCAN12L1 0.29 5.91 0.31 8.38e-9 Depression; CRC cis rs1559088 0.948 rs6510346 chr19:33598526 T/A cg27124370 chr19:33622961 WDR88 0.45 6.34 0.33 7.42e-10 Bone ultrasound measurement (broadband ultrasound attenuation); CRC cis rs1559088 1.000 rs7245404 chr19:33550589 C/T cg27124370 chr19:33622961 WDR88 0.41 5.71 0.3 2.49e-8 Bone ultrasound measurement (broadband ultrasound attenuation); CRC trans rs10506458 1.000 rs73128779 chr12:63441852 T/G cg03429785 chr15:59498649 MYO1E;LDHAL6B -1.33 -19.18 -0.73 1.47e-55 Hemostatic factors and hematological phenotypes; CRC cis rs12541635 0.966 rs7839195 chr8:107020193 G/A cg10147462 chr8:107024639 NA 0.41 6.84 0.35 3.94e-11 Age of smoking initiation; CRC cis rs1799949 1.000 rs2271574 chr17:41327648 T/C cg19454999 chr17:41278357 BRCA1;NBR2 0.55 8.62 0.43 2.95e-16 Menopause (age at onset); CRC cis rs11758351 0.660 rs1997768 chr6:26217728 C/T cg10723962 chr6:26240782 HIST1H4F 0.39 6.53 0.34 2.48e-10 Gout;Renal underexcretion gout; CRC cis rs362272 0.545 rs2749782 chr4:3339761 A/G cg20495365 chr4:3371291 RGS12 -0.33 -5.72 -0.3 2.38e-8 Serum sulfate level; CRC cis rs4862750 0.874 rs6553027 chr4:187875777 T/C cg22105103 chr4:187893119 NA 0.64 11.6 0.54 2.48e-26 Lobe attachment (rater-scored or self-reported); CRC cis rs9648716 1.000 rs59055264 chr7:140604873 T/C cg10747023 chr7:140774559 NA 0.45 5.89 0.31 9.29e-9 Type 2 diabetes; CRC cis rs7072216 0.763 rs2274243 chr10:100175267 T/C cg26618903 chr10:100175079 PYROXD2 -0.54 -8.87 -0.44 4.79e-17 Metabolite levels; CRC cis rs9611519 0.780 rs5751072 chr22:41656509 C/T cg06634786 chr22:41940651 POLR3H -0.42 -5.94 -0.31 7.1e-9 Neuroticism; CRC cis rs798554 0.797 rs798487 chr7:2802943 G/A cg17321639 chr7:2759063 NA -0.47 -6.16 -0.32 2.07e-9 Height; CRC cis rs13082711 0.595 rs4973762 chr3:27364789 A/T cg02860705 chr3:27208620 NA 0.86 11.59 0.54 2.89e-26 Systolic blood pressure;Diastolic blood pressure;Blood pressure; CRC trans rs208520 0.874 rs208512 chr6:66943869 C/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.92 -11.92 -0.55 1.77e-27 Exhaled nitric oxide output; CRC cis rs1355223 0.583 rs1553757 chr11:34867089 G/A cg24088639 chr11:34937564 PDHX;APIP -0.57 -8.25 -0.41 3.98e-15 Systemic lupus erythematosus and Systemic sclerosis; CRC cis rs2836950 0.501 rs2056844 chr21:40670460 G/C cg11890956 chr21:40555474 PSMG1 -0.63 -9.33 -0.46 1.66e-18 Menarche (age at onset); CRC cis rs13108904 0.870 rs4974543 chr4:1251222 A/G cg23123621 chr4:1343375 KIAA1530 0.32 5.64 0.3 3.65e-8 Obesity-related traits; CRC trans rs11654801 0.812 rs8080233 chr17:20866854 A/C cg23759823 chr7:139672531 TBXAS1 -0.38 -6.21 -0.32 1.56e-9 Mosquito bite size; CRC cis rs9291683 0.588 rs3796829 chr4:10019138 C/G cg11266682 chr4:10021025 SLC2A9 0.54 11.57 0.54 3.2e-26 Bone mineral density; CRC cis rs798554 0.757 rs1182187 chr7:2870454 T/G cg13628971 chr7:2884303 GNA12 0.49 6.64 0.34 1.26e-10 Height; CRC cis rs921968 0.565 rs3755045 chr2:219609162 T/G cg02176678 chr2:219576539 TTLL4 -0.39 -6.23 -0.32 1.41e-9 Mean corpuscular hemoglobin concentration; CRC cis rs2120019 1.000 rs7175720 chr15:75348962 C/G cg09165964 chr15:75287851 SCAMP5 0.82 12.33 0.56 5.48e-29 Blood trace element (Zn levels); CRC cis rs2179367 0.959 rs537354 chr6:149665937 C/T cg07828024 chr6:149772892 ZC3H12D -0.38 -6.13 -0.32 2.48e-9 Dupuytren's disease; CRC cis rs59918340 0.728 rs4961340 chr8:142232002 G/A cg03316587 chr8:142245164 NA -0.4 -6.02 -0.32 4.58e-9 Immature fraction of reticulocytes; CRC cis rs6963495 0.769 rs11556986 chr7:105177041 A/T cg02135003 chr7:105160482 PUS7 -0.73 -10.37 -0.5 5.48e-22 Bipolar disorder (body mass index interaction); CRC cis rs6582630 0.555 rs10880611 chr12:38509316 C/G cg26384229 chr12:38710491 ALG10B 0.71 10.1 0.49 4.6e-21 Drug-induced liver injury (flucloxacillin); CRC cis rs7917772 0.503 rs6584510 chr10:104299868 T/G cg22532475 chr10:104410764 TRIM8 -0.36 -6.62 -0.34 1.43e-10 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC cis rs2832077 0.527 rs1048546 chr21:30244877 G/T cg08807101 chr21:30365312 RNF160 -0.4 -5.62 -0.3 3.97e-8 Cognitive test performance; CRC cis rs172166 0.637 rs1233708 chr6:28173219 C/T cg15845792 chr6:28175446 NA 0.77 11.52 0.54 5.21e-26 Cardiac Troponin-T levels; CRC cis rs1538970 0.962 rs2298018 chr1:45813441 T/C cg05343316 chr1:45956843 TESK2 0.64 8.98 0.44 2.19e-17 Platelet count; CRC cis rs12451471 0.529 rs2278620 chr17:78083565 G/A cg12100956 chr17:78086420 GAA -0.39 -6.1 -0.32 2.97e-9 Plateletcrit;Mean corpuscular hemoglobin concentration; CRC cis rs13108904 0.901 rs7668661 chr4:1300172 A/G cg20092199 chr4:1342459 KIAA1530 0.41 7.61 0.39 2.85e-13 Obesity-related traits; CRC trans rs561341 0.941 rs17780080 chr17:30343146 G/A cg27661571 chr11:113659931 NA -0.96 -11.16 -0.52 9.58e-25 Hip circumference adjusted for BMI; CRC cis rs727505 0.821 rs73225498 chr7:124704197 C/T cg23710748 chr7:124431027 NA -0.79 -13.9 -0.61 6.97e-35 Lewy body disease; CRC cis rs9768139 0.935 rs6953748 chr7:158121184 G/A cg23298862 chr7:158159286 PTPRN2 -0.5 -8.21 -0.41 4.93e-15 Calcium levels; CRC cis rs853679 0.517 rs36078605 chr6:28078032 A/C cg23161317 chr6:28129485 ZNF389 0.54 6.6 0.34 1.64e-10 Depression; CRC cis rs11098499 0.863 rs10009626 chr4:120470005 T/C cg24375607 chr4:120327624 NA 0.48 7.45 0.38 8.51e-13 Corneal astigmatism; CRC cis rs10883723 0.773 rs11191303 chr10:104255158 T/C cg22532475 chr10:104410764 TRIM8 -0.37 -6.86 -0.35 3.51e-11 Allergic disease (asthma, hay fever or eczema); CRC cis rs6952808 0.825 rs4236277 chr7:1942270 C/T cg21782813 chr7:2030301 MAD1L1 0.46 7.82 0.4 7.07e-14 Bipolar disorder and schizophrenia; CRC cis rs1728785 0.892 rs1170427 chr16:68603852 G/T cg02972257 chr16:68554789 NA -0.6 -7.52 -0.38 5.1e-13 Ulcerative colitis; CRC cis rs2580764 0.678 rs2255112 chr2:55200800 T/G cg09592903 chr2:55203963 RTN4 0.76 12.1 0.55 4.05e-28 Mean platelet volume; CRC cis rs7587476 0.862 rs13001462 chr2:215678346 G/A cg04004882 chr2:215674386 BARD1 0.67 9.35 0.46 1.43e-18 Neuroblastoma; CRC trans rs10139154 0.824 rs229222 chr14:31004351 T/A cg18753625 chr19:36705707 ZNF565;ZNF146 -0.42 -6.01 -0.31 4.93e-9 Amyotrophic lateral sclerosis; CRC cis rs7586673 0.866 rs7579662 chr2:161915810 G/A cg22496339 chr2:162101262 NA 0.48 6.59 0.34 1.7e-10 Intelligence (multi-trait analysis); CRC cis rs477895 0.713 rs67546972 chr11:63962162 G/A cg05016508 chr11:63871570 FLRT1;MACROD1 0.54 6.94 0.36 2.08e-11 Mean platelet volume; CRC trans rs17685 0.712 rs9800948 chr7:75810473 A/G cg19862616 chr7:65841803 NCRNA00174 0.92 16.19 0.67 9.46e-44 Coffee consumption;Coffee consumption (cups per day); CRC cis rs6598955 0.724 rs4659420 chr1:26614333 G/A cg00852783 chr1:26633632 UBXN11 0.42 6.84 0.35 3.87e-11 Obesity-related traits; CRC cis rs1552244 0.554 rs17050704 chr3:10045734 T/C cg00166722 chr3:10149974 C3orf24 0.43 6.37 0.33 6.32e-10 Alzheimer's disease; CRC cis rs6961069 0.745 rs3211839 chr7:80280462 G/A cg04458919 chr7:80252533 CD36 -0.33 -5.68 -0.3 3.03e-8 Platelet count; CRC trans rs1005277 0.579 rs2474563 chr10:38375938 T/C cg23533926 chr12:111358616 MYL2 -0.52 -7.87 -0.4 5.09e-14 Extrinsic epigenetic age acceleration; CRC cis rs12745968 0.653 rs11164791 chr1:93119634 C/T cg17283838 chr1:93427260 FAM69A -0.46 -6.2 -0.32 1.73e-9 Bipolar disorder and schizophrenia; CRC cis rs4780401 0.703 rs8191295 chr16:11766905 A/G cg01061890 chr16:11836724 TXNDC11 -0.42 -5.73 -0.3 2.28e-8 Rheumatoid arthritis; CRC cis rs7835763 0.692 rs2514744 chr8:119104321 A/G cg11592677 chr8:119110466 EXT1 0.38 6.25 0.33 1.29e-9 Autism spectrum disorder; CRC cis rs1799949 0.896 rs35908185 chr17:41255111 A/T cg01879757 chr17:41196368 BRCA1 -0.43 -6.49 -0.34 3.24e-10 Menopause (age at onset); CRC cis rs13191362 0.507 rs7772787 chr6:163190981 C/T cg21926612 chr6:163149169 PACRG;PARK2 0.51 8.33 0.42 2.21e-15 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs12477438 0.501 rs13033012 chr2:99795149 T/C cg26064155 chr2:99771622 LIPT1;TSGA10 0.77 13.13 0.59 5.79e-32 Chronic sinus infection; CRC cis rs7264396 0.790 rs2425160 chr20:34425968 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.61 -10.48 -0.5 2.3e-22 Total cholesterol levels; CRC trans rs57221529 0.766 rs17497684 chr5:558307 T/C cg25482853 chr8:67687455 SGK3 1.24 15.65 0.65 1.15e-41 Lung disease severity in cystic fibrosis; CRC cis rs2836974 0.568 rs2836969 chr21:40648265 G/A cg06238570 chr21:40685208 BRWD1 -0.81 -12.91 -0.58 4.11e-31 Cognitive function; CRC cis rs11098499 0.863 rs11098531 chr4:120465001 G/A cg24375607 chr4:120327624 NA 0.48 7.45 0.38 8.51e-13 Corneal astigmatism; CRC cis rs1129187 0.934 rs9471974 chr6:42918984 T/A cg21280719 chr6:42927975 GNMT -0.44 -9.68 -0.47 1.17e-19 Alzheimer's disease in APOE e4+ carriers; CRC cis rs10504229 1.000 rs67384205 chr8:58180348 C/G cg24829409 chr8:58192753 C8orf71 -0.68 -11.34 -0.53 2.27e-25 Developmental language disorder (linguistic errors); CRC cis rs668210 0.643 rs549334 chr11:65774659 C/G cg02202077 chr11:65769826 EIF1AD;BANF1 0.49 6.45 0.33 4.04e-10 Cerebrospinal fluid biomarker levels; CRC cis rs11190604 1.000 rs11190613 chr10:102313997 C/T cg07080220 chr10:102295463 HIF1AN -0.48 -5.96 -0.31 6.36e-9 Palmitoleic acid (16:1n-7) levels; CRC cis rs1223397 0.938 rs3817741 chr6:13279507 A/G cg06879394 chr6:13274151 PHACTR1 -0.51 -6.38 -0.33 5.86e-10 Blood pressure; CRC cis rs2075371 0.829 rs11770521 chr7:133936251 A/C cg20476274 chr7:133979776 SLC35B4 0.71 11.52 0.54 5.04e-26 Mean platelet volume; CRC cis rs3743162 0.553 rs12900463 chr15:85415386 T/C cg17507749 chr15:85114479 UBE2QP1 0.52 6.89 0.36 2.8e-11 Alzheimer's disease (age of onset); CRC cis rs11148252 0.508 rs6561671 chr13:53182314 G/A cg00495681 chr13:53174319 NA 0.86 15.73 0.66 5.56e-42 Lewy body disease; CRC cis rs2976388 0.647 rs2164307 chr8:143788831 A/T cg04969067 chr8:143858791 LYNX1 0.45 7.67 0.39 1.97e-13 Urinary tract infection frequency; CRC cis rs7072216 0.727 rs3750603 chr10:100175536 A/T cg26618903 chr10:100175079 PYROXD2 -0.54 -8.95 -0.44 2.75e-17 Metabolite levels; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg16342149 chr9:86238535 C9orf103 0.46 6.5 0.34 2.96e-10 Response to antipsychotic treatment; CRC cis rs12586317 0.547 rs112510746 chr14:35491833 T/G cg16230307 chr14:35515116 FAM177A1 0.9 10.55 0.5 1.36e-22 Psoriasis; CRC trans rs61931739 0.500 rs3922568 chr12:34560107 A/C cg26384229 chr12:38710491 ALG10B 0.6 8.84 0.44 5.75e-17 Morning vs. evening chronotype; CRC cis rs2227564 0.649 rs2242258 chr10:75607168 T/C cg16540259 chr10:75572220 NDST2 -0.45 -6.46 -0.34 3.74e-10 Crohn's disease;Inflammatory bowel disease; CRC cis rs9549367 0.713 rs9549357 chr13:113860121 C/T cg00898013 chr13:113819073 PROZ -0.53 -7.08 -0.36 8.6e-12 Platelet distribution width; CRC cis rs28386778 0.897 rs9906247 chr17:61857314 T/C cg11494091 chr17:61959527 GH2 0.63 10.64 0.51 6.2e-23 Prudent dietary pattern; CRC cis rs17095355 0.786 rs58096078 chr10:111734286 C/G cg00817464 chr10:111662876 XPNPEP1 -0.6 -8.28 -0.42 3.2e-15 Biliary atresia; CRC cis rs9487051 0.676 rs9372208 chr6:109596168 A/G cg01475377 chr6:109611718 NA -0.37 -6.58 -0.34 1.85e-10 Reticulocyte fraction of red cells; CRC cis rs2032447 0.802 rs199755 chr6:25990367 G/A cg18357526 chr6:26021779 HIST1H4A 0.76 11.29 0.53 3.32e-25 Intelligence (multi-trait analysis); CRC cis rs4665809 0.590 rs6730317 chr2:26419482 C/T cg26119090 chr2:26468346 HADHA;HADHB -1.0 -13.97 -0.61 3.8e-35 Gut microbiome composition (summer); CRC cis rs2336384 1.000 rs873457 chr1:12046334 C/G cg13216073 chr1:12042593 MFN2 0.48 7.2 0.37 4.14e-12 Platelet count; CRC cis rs3731896 1.000 rs3731896 chr2:220146402 C/T cg00496455 chr2:220118770 TUBA4A;TUBA4B 0.52 6.04 0.32 4.21e-9 Educational attainment; CRC cis rs4363385 0.747 rs11205151 chr1:152961496 G/A cg25856811 chr1:152973957 SPRR3 -0.26 -7.29 -0.37 2.3e-12 Inflammatory skin disease; CRC cis rs6951245 1.000 rs76804143 chr7:1082021 C/T cg21664854 chr7:1097933 C7orf50;GPR146 0.79 8.94 0.44 2.89e-17 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs4975616 0.714 rs27069 chr5:1347128 C/T cg06550200 chr5:1325588 CLPTM1L -0.74 -11.89 -0.55 2.26e-27 Lung cancer; CRC cis rs1552244 1.000 rs35220123 chr3:10083169 C/T cg02579736 chr3:10068473 FANCD2;CIDECP 1.05 14.06 0.61 1.71e-35 Alzheimer's disease; CRC cis rs7927771 0.864 rs4752838 chr11:47466006 G/A cg20307385 chr11:47447363 PSMC3 -0.63 -9.23 -0.45 3.36e-18 Subjective well-being; CRC cis rs6424115 0.931 rs2473377 chr1:24148260 T/C cg15997130 chr1:24165203 NA 0.72 10.96 0.52 4.79e-24 Immature fraction of reticulocytes; CRC cis rs7647973 0.593 rs28535523 chr3:49848414 C/T cg03060546 chr3:49711283 APEH -0.66 -8.04 -0.41 1.68e-14 Menarche (age at onset); CRC cis rs853679 0.760 rs2299029 chr6:28198831 G/A cg06470822 chr6:28175283 NA 0.79 8.6 0.43 3.24e-16 Depression; CRC trans rs459571 0.959 rs410876 chr9:136893867 C/A cg09836344 chr4:1243392 C4orf42;CTBP1 -0.81 -11.28 -0.53 3.57e-25 Platelet distribution width; CRC cis rs9469578 0.681 rs78748610 chr6:33714412 T/C cg18708504 chr6:33715942 IP6K3 0.66 7.56 0.38 4e-13 Phosphorus levels; CRC cis rs3785574 0.962 rs62077483 chr17:61806380 C/T cg23090583 chr17:61904693 PSMC5;FTSJ3 0.64 9.41 0.46 8.67e-19 Height; CRC cis rs1448094 0.512 rs6539932 chr12:86247497 T/C cg19622623 chr12:86230825 RASSF9 -0.41 -6.71 -0.35 8.6e-11 Major depressive disorder; CRC cis rs9467711 0.606 rs68072215 chr6:26377927 T/C cg14345882 chr6:26364793 BTN3A2 0.7 6.03 0.32 4.53e-9 Autism spectrum disorder or schizophrenia; CRC cis rs6460942 0.544 rs17650302 chr7:12143138 C/T cg06484146 chr7:12443880 VWDE -0.56 -6.18 -0.32 1.87e-9 Coronary artery disease; CRC trans rs6550704 0.687 rs9865314 chr3:22634337 A/G cg01398415 chr1:226309536 NA -0.41 -5.97 -0.31 6.24e-9 Daytime sleep phenotypes; CRC cis rs4722166 0.630 rs12537614 chr7:22789551 C/G cg05472934 chr7:22766657 IL6 0.75 12.28 0.56 8.33e-29 Lung cancer; CRC cis rs910187 0.605 rs6063079 chr20:45804275 C/G cg27589058 chr20:45804311 EYA2 -0.42 -8.55 -0.43 4.74e-16 Migraine; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg19281693 chr22:42666674 NA 0.45 6.66 0.34 1.12e-10 Intelligence (multi-trait analysis); CRC cis rs72615157 0.561 rs113401658 chr7:99858505 C/T cg00814883 chr7:100076585 TSC22D4 -0.52 -5.87 -0.31 1.07e-8 Lung function (FEV1/FVC); CRC cis rs1577917 0.559 rs1173418 chr6:86402916 G/A cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A 0.55 7.76 0.39 1.1e-13 Response to antipsychotic treatment; CRC cis rs9916302 0.851 rs2338795 chr17:37399364 T/G cg00129232 chr17:37814104 STARD3 -0.54 -8.03 -0.4 1.72e-14 Glomerular filtration rate (creatinine); CRC cis rs2070488 1.000 rs13074025 chr3:38455704 C/A cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.9 16.19 0.67 9.15e-44 Electrocardiographic conduction measures; CRC trans rs2163503 0.666 rs481940 chr1:71442457 C/T cg23933503 chr22:44255884 SULT4A1 0.37 6.24 0.33 1.38e-9 Intelligence (multi-trait analysis); CRC trans rs2303319 0.504 rs12470590 chr2:162493102 A/G cg10272801 chr16:14013773 ERCC4 -0.69 -6.06 -0.32 3.8e-9 Cognitive function; CRC cis rs892961 0.932 rs7224442 chr17:75413439 A/G cg05865280 chr17:75406074 SEPT9 0.63 14.51 0.62 3.27e-37 Airflow obstruction; CRC cis rs13191362 0.810 rs28360533 chr6:162996742 A/G cg21926612 chr6:163149169 PACRG;PARK2 0.82 11.39 0.53 1.52e-25 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs10504229 0.683 rs11774847 chr8:58140775 T/A cg02725872 chr8:58115012 NA -0.58 -8.11 -0.41 1.03e-14 Developmental language disorder (linguistic errors); CRC cis rs6840360 0.555 rs4554052 chr4:152726610 T/C cg09659197 chr4:152720779 NA -0.44 -8.97 -0.44 2.3e-17 Intelligence (multi-trait analysis); CRC cis rs8180040 1.000 rs1076394 chr3:47322781 G/A cg27129171 chr3:47204927 SETD2 -0.66 -10.09 -0.49 5.03e-21 Colorectal cancer; CRC cis rs9303280 0.743 rs12946510 chr17:37912377 C/T cg20243544 chr17:37824526 PNMT 0.38 5.73 0.3 2.26e-8 Self-reported allergy; CRC cis rs9467711 0.523 rs9379853 chr6:26357635 A/G cg14345882 chr6:26364793 BTN3A2 0.64 5.63 0.3 3.85e-8 Autism spectrum disorder or schizophrenia; CRC cis rs1348850 0.793 rs6736390 chr2:178480314 T/C cg22681709 chr2:178499509 PDE11A -0.4 -7.51 -0.38 5.58e-13 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs11191270 0.554 rs11191253 chr10:104066507 A/T cg15320455 chr10:103880129 LDB1 0.73 6.6 0.34 1.63e-10 Intelligence (multi-trait analysis); CRC cis rs977987 0.843 rs12927562 chr16:75482860 G/A cg03315344 chr16:75512273 CHST6 0.55 9.33 0.46 1.62e-18 Dupuytren's disease; CRC cis rs3806843 0.868 rs2262573 chr5:140123627 T/A cg16607685 chr5:140181889 PCDHA2;PCDHA1;PCDHA3 0.25 5.98 0.31 5.91e-9 Depressive symptoms (multi-trait analysis); CRC cis rs7319311 0.899 rs9521729 chr13:111029970 G/A cg05272587 chr13:111038400 COL4A2 0.41 6.27 0.33 1.11e-9 Bipolar disorder and schizophrenia; CRC trans rs17807624 0.780 rs13277929 chr8:11453030 G/A cg06636001 chr8:8085503 FLJ10661 0.45 6.2 0.32 1.73e-9 Systemic lupus erythematosus; CRC cis rs1552244 0.938 rs7652951 chr3:10063763 A/C cg18598329 chr3:10140678 FANCD2;C3orf24 -0.88 -12.22 -0.56 1.48e-28 Alzheimer's disease; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg25454755 chr9:102584145 NR4A3 0.47 6.01 0.31 4.84e-9 Thyroid stimulating hormone; CRC cis rs2153535 0.601 rs9505451 chr6:8469950 C/T cg07606381 chr6:8435919 SLC35B3 0.67 10.7 0.51 4.01e-23 Motion sickness; CRC cis rs6860806 0.531 rs272888 chr5:131665423 T/C cg24060327 chr5:131705240 SLC22A5 -0.51 -7.65 -0.39 2.28e-13 Breast cancer; CRC cis rs9733 0.596 rs2867300 chr1:150666990 C/G cg18016565 chr1:150552671 MCL1 0.46 6.63 0.34 1.41e-10 Tonsillectomy; CRC cis rs7647973 0.922 rs57273516 chr3:49483074 A/G cg07690219 chr3:49449608 TCTA;RHOA -0.53 -6.13 -0.32 2.56e-9 Menarche (age at onset); CRC trans rs5756813 0.727 rs13055462 chr22:38184685 A/G cg19894588 chr14:64061835 NA -0.57 -7.82 -0.4 7.26e-14 Optic cup area;Vertical cup-disc ratio; CRC cis rs514406 0.861 rs10888755 chr1:53240829 A/G cg24675658 chr1:53192096 ZYG11B 0.53 7.92 0.4 3.7e-14 Monocyte count; CRC cis rs9486715 0.758 rs2971610 chr6:97027380 C/T cg18709589 chr6:96969512 KIAA0776 -0.5 -7.39 -0.38 1.25e-12 Headache; CRC cis rs12477438 0.834 rs11903311 chr2:99701807 T/C cg26064155 chr2:99771622 LIPT1;TSGA10 -0.64 -8.91 -0.44 3.5e-17 Chronic sinus infection; CRC trans rs2228479 0.850 rs2238527 chr16:89840708 C/A cg24644049 chr4:85504048 CDS1 0.92 7.68 0.39 1.79e-13 Skin colour saturation; CRC cis rs2652834 0.904 rs8032506 chr15:63371644 G/A cg05507819 chr15:63340323 TPM1 -0.45 -5.71 -0.3 2.58e-8 HDL cholesterol; CRC cis rs736408 0.609 rs2336545 chr3:52787603 C/T cg08222913 chr3:52553049 STAB1 0.34 6.13 0.32 2.45e-9 Bipolar disorder; CRC cis rs7208859 0.623 rs11651858 chr17:29170718 A/G cg01831904 chr17:28903510 LRRC37B2 -0.55 -5.75 -0.3 2.01e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg16140449 chr1:178511703 C1orf220 0.49 7.06 0.36 1.01e-11 Intelligence (multi-trait analysis); CRC cis rs3806843 1.000 rs1548699 chr5:140164918 T/C cg16607685 chr5:140181889 PCDHA2;PCDHA1;PCDHA3 -0.27 -6.25 -0.33 1.25e-9 Depressive symptoms (multi-trait analysis); CRC cis rs8077889 0.917 rs4793038 chr17:41916761 A/T cg26893861 chr17:41843967 DUSP3 0.87 12.63 0.57 4.37e-30 Triglycerides; CRC cis rs9905704 0.846 rs304267 chr17:56799380 A/G cg12560992 chr17:57184187 TRIM37 0.54 7.92 0.4 3.75e-14 Testicular germ cell tumor; CRC cis rs7647973 0.769 rs6772452 chr3:49040462 A/G cg20833759 chr3:49053208 WDR6;DALRD3 0.63 10.33 0.49 7.54e-22 Menarche (age at onset); CRC trans rs1814175 0.817 rs10839401 chr11:49876144 C/T cg15704280 chr7:45808275 SEPT13 -0.96 -18.48 -0.71 8.12e-53 Height; CRC cis rs2629540 0.847 rs11245342 chr10:126414084 C/T cg08799069 chr10:126477246 METTL10 0.6 7.4 0.38 1.16e-12 Cocaine dependence; CRC cis rs7827545 1.000 rs6578232 chr8:135565690 G/A cg17885191 chr8:135476712 NA 0.54 7.41 0.38 1.06e-12 Hypertension (SNP x SNP interaction); CRC cis rs832540 0.830 rs252907 chr5:56120646 G/A cg20203395 chr5:56204925 C5orf35 -0.41 -5.81 -0.3 1.5e-8 Coronary artery disease; CRC cis rs7927771 0.697 rs11039307 chr11:47611152 C/T cg05585544 chr11:47624801 NA -0.46 -8.12 -0.41 9.43e-15 Subjective well-being; CRC cis rs3772130 0.923 rs28674947 chr3:121529421 C/T cg20356878 chr3:121714668 ILDR1 0.51 8.05 0.41 1.5e-14 Cognitive performance; CRC cis rs4750440 0.670 rs7917314 chr10:14029682 G/A cg00551146 chr10:14014579 FRMD4A 0.36 5.85 0.31 1.19e-8 Adiponectin levels; CRC cis rs6903823 0.508 rs1233660 chr6:28260249 T/A cg21251018 chr6:28226885 NKAPL 0.56 9.68 0.47 1.19e-19 Pulmonary function; CRC cis rs7772486 0.719 rs2206141 chr6:146086192 A/G cg13319975 chr6:146136371 FBXO30 0.49 7.16 0.37 5.24e-12 Lobe attachment (rater-scored or self-reported); CRC cis rs853679 0.882 rs4713139 chr6:28092685 C/T cg15845792 chr6:28175446 NA 0.8 6.52 0.34 2.67e-10 Depression; CRC cis rs67311347 0.956 rs9817233 chr3:40425618 G/T cg24209194 chr3:40518798 ZNF619 0.4 5.62 0.3 4e-8 Renal cell carcinoma; CRC cis rs6543140 0.929 rs11465700 chr2:103057668 G/A cg03938978 chr2:103052716 IL18RAP 0.45 7.03 0.36 1.2e-11 Blood protein levels; CRC cis rs6952808 1.000 rs4721122 chr7:1893311 C/G cg00106254 chr7:1943704 MAD1L1 -0.39 -5.71 -0.3 2.57e-8 Bipolar disorder and schizophrenia; CRC cis rs12472274 0.941 rs12616232 chr2:239080093 C/T cg17459225 chr2:239074497 NA 0.89 15.26 0.64 3.92e-40 Phospholipid levels (plasma); CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg13627451 chr15:52043674 TMOD2;LYSMD2 0.37 6.05 0.32 3.92e-9 Obesity-related traits; CRC trans rs875971 0.545 rs35459055 chr7:65944386 G/A cg02869306 chr7:64672164 INTS4L1 -0.41 -6.01 -0.31 4.91e-9 Aortic root size; CRC cis rs589448 0.902 rs528974 chr12:69765918 A/T cg22834771 chr12:69754056 YEATS4 -0.56 -8.68 -0.43 1.93e-16 Cerebrospinal fluid biomarker levels; CRC cis rs10484885 0.824 rs72919982 chr6:90532600 C/G cg13799429 chr6:90582589 CASP8AP2 -0.72 -7.73 -0.39 1.3e-13 QRS interval (sulfonylurea treatment interaction); CRC cis rs1267303 0.642 rs1267301 chr1:46992853 C/G cg25110126 chr1:46999211 NA -0.59 -8.31 -0.42 2.46e-15 Monobrow; CRC cis rs6570726 0.935 rs369458 chr6:145812809 A/G cg23711669 chr6:146136114 FBXO30 0.67 11.98 0.55 1.13e-27 Lobe attachment (rater-scored or self-reported); CRC cis rs1448094 0.533 rs7307617 chr12:86151317 T/C cg25456477 chr12:86230367 RASSF9 -0.36 -6.14 -0.32 2.31e-9 Major depressive disorder; CRC cis rs10504229 0.595 rs116490935 chr8:58117531 A/G cg22535103 chr8:58192502 C8orf71 -0.7 -9.19 -0.45 4.45e-18 Developmental language disorder (linguistic errors); CRC cis rs17384381 1.000 rs12132677 chr1:85879613 A/C cg16011679 chr1:85725395 C1orf52 0.65 6.68 0.35 1.05e-10 Lobe attachment (rater-scored or self-reported); CRC cis rs490234 0.812 rs13292924 chr9:128409728 C/T cg14078157 chr9:128172775 NA -0.43 -6.71 -0.35 8.71e-11 Mean arterial pressure; CRC cis rs11971779 0.616 rs10269683 chr7:139100868 G/A cg07862535 chr7:139043722 LUC7L2 0.58 7.32 0.37 1.87e-12 Diisocyanate-induced asthma; CRC cis rs11711311 1.000 rs9848993 chr3:113497914 T/G cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.52 -7.03 -0.36 1.17e-11 IgG glycosylation; CRC cis rs7586879 0.828 rs2384056 chr2:25092649 G/A cg04586622 chr2:25135609 ADCY3 -0.55 -9.36 -0.46 1.32e-18 Body mass index; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg04779191 chr16:69166964 CHTF8;CIRH1A 0.5 6.43 0.33 4.51e-10 Thyroid stimulating hormone; CRC cis rs8072100 0.905 rs11651766 chr17:45574931 G/T cg08085267 chr17:45401833 C17orf57 -0.63 -10.0 -0.48 9.58e-21 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs2404602 0.583 rs2176623 chr15:76568579 C/T cg26408565 chr15:76604113 ETFA -0.37 -5.82 -0.31 1.39e-8 Blood metabolite levels; CRC cis rs7044106 0.762 rs966397 chr9:123453312 G/A cg09586646 chr9:123605570 PSMD5;LOC253039 0.6 8.83 0.44 6.35e-17 Hip circumference adjusted for BMI; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg24787081 chr4:184365198 CDKN2AIP 0.47 6.77 0.35 5.8e-11 Response to antipsychotic treatment; CRC cis rs939658 0.805 rs35462901 chr15:79442201 C/T cg17916960 chr15:79447300 NA -0.44 -7.1 -0.36 7.68e-12 Refractive error; CRC cis rs4713118 0.513 rs149955 chr6:28036225 G/C cg23161317 chr6:28129485 ZNF389 0.45 6.42 0.33 4.64e-10 Parkinson's disease; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg10425946 chr17:3571430 TMEM93;TAX1BP3 0.43 6.55 0.34 2.25e-10 Intelligence (multi-trait analysis); CRC cis rs354033 1.000 rs354031 chr7:149285921 A/G cg24335155 chr7:149193227 ZNF746 0.37 5.78 0.3 1.72e-8 Multiple sclerosis; CRC cis rs79349575 0.749 rs2270574 chr17:47022270 C/T cg00947319 chr17:47005597 UBE2Z -0.34 -5.89 -0.31 9.32e-9 Type 2 diabetes; CRC cis rs711245 0.670 rs7560321 chr2:36822318 C/G cg01206211 chr2:36825736 FEZ2 -0.56 -9.9 -0.48 2.19e-20 Height; CRC cis rs10971721 0.822 rs72725374 chr9:33840649 T/C cg13495928 chr9:33750294 PRSS3 0.55 5.9 0.31 9.17e-9 Body mass index; CRC trans rs9914544 0.966 rs1737943 chr17:18841590 A/G cg04702396 chr17:15466718 FAM18B2 -0.44 -6.21 -0.32 1.56e-9 Educational attainment (years of education); CRC cis rs4862750 0.914 rs6553026 chr4:187875648 C/T cg27532560 chr4:187881888 NA -0.55 -9.91 -0.48 1.97e-20 Lobe attachment (rater-scored or self-reported); CRC cis rs11838776 0.522 rs7318424 chr13:111021623 C/G cg06243866 chr13:111019493 COL4A2 0.39 6.2 0.32 1.7e-9 Coronary artery disease; CRC cis rs6539267 0.741 rs7314289 chr12:106686260 A/C cg00173435 chr12:106696525 TCP11L2 0.52 7.01 0.36 1.38e-11 Tourette syndrome; CRC cis rs73200209 0.744 rs17498452 chr12:116538854 C/T cg01776926 chr12:116560359 MED13L 0.6 7.19 0.37 4.29e-12 Total body bone mineral density; CRC cis rs644148 0.836 rs2571112 chr19:45000319 T/A cg15540054 chr19:45004280 ZNF180 -0.59 -8.28 -0.42 3.11e-15 Personality dimensions; CRC cis rs4332037 0.539 rs55790766 chr7:2021248 C/T cg21155852 chr7:2048760 MAD1L1 -0.52 -7.01 -0.36 1.33e-11 Bipolar disorder; CRC cis rs7923609 0.967 rs7085621 chr10:65208926 T/C cg08743896 chr10:65200160 JMJD1C -0.42 -6.12 -0.32 2.65e-9 Educational attainment;Liver enzyme levels (alkaline phosphatase); CRC trans rs2243480 1.000 rs59794892 chr7:65415873 G/A cg10756647 chr7:56101905 PSPH 0.73 8.01 0.4 1.97e-14 Diabetic kidney disease; CRC cis rs951366 0.622 rs11580015 chr1:205676088 G/C cg14159672 chr1:205819179 PM20D1 0.7 9.81 0.48 4.43e-20 Menarche (age at onset); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg11234017 chr17:42767172 CCDC43 0.45 6.45 0.34 4.04e-10 Response to antipsychotic treatment; CRC cis rs7772486 0.719 rs2206141 chr6:146086192 A/G cg23711669 chr6:146136114 FBXO30 -0.78 -13.21 -0.59 3e-32 Lobe attachment (rater-scored or self-reported); CRC cis rs35306767 0.903 rs7074642 chr10:878359 A/G cg26597838 chr10:835615 NA 0.92 11.26 0.53 4.21e-25 Eosinophil percentage of granulocytes; CRC trans rs7819412 0.540 rs11777355 chr8:11044689 A/G cg06636001 chr8:8085503 FLJ10661 -0.45 -6.45 -0.34 4.02e-10 Triglycerides; CRC cis rs7107174 0.901 rs10899473 chr11:78042983 A/C cg02023728 chr11:77925099 USP35 0.52 8.63 0.43 2.73e-16 Testicular germ cell tumor; CRC cis rs1865760 0.865 rs9393678 chr6:25945819 C/T cg17691542 chr6:26056736 HIST1H1C 0.52 7.7 0.39 1.63e-13 Height; CRC cis rs921968 0.643 rs833083 chr2:219336959 A/T cg02176678 chr2:219576539 TTLL4 -0.5 -7.97 -0.4 2.64e-14 Mean corpuscular hemoglobin concentration; CRC cis rs2286885 0.896 rs62578061 chr9:129248219 C/T cg15282417 chr9:129245246 FAM125B 0.46 8.49 0.42 7.01e-16 Intraocular pressure; CRC cis rs12983728 0.732 rs34003091 chr19:58662254 T/C cg24884572 chr19:58661833 ZNF329 0.79 8.67 0.43 1.97e-16 Cholesterol, total; CRC cis rs6586163 0.546 rs12359362 chr10:90753145 G/C cg03111039 chr10:90751583 FAS;ACTA2 0.82 12.56 0.57 7.98e-30 Chronic lymphocytic leukemia; CRC cis rs2742417 0.967 rs9877499 chr3:45734404 G/A cg04837898 chr3:45731254 SACM1L -0.34 -5.69 -0.3 2.81e-8 Response to anti-depressant treatment in major depressive disorder; CRC cis rs4234798 0.933 rs7678751 chr4:7219035 A/G cg18431297 chr4:7219810 SORCS2 0.56 10.06 0.48 6.31e-21 Insulin-like growth factors; CRC trans rs2228479 0.850 rs11641147 chr16:89813589 C/T cg24644049 chr4:85504048 CDS1 0.9 7.46 0.38 7.69e-13 Skin colour saturation; CRC cis rs4972806 0.814 rs1446575 chr2:177047801 A/C cg13092806 chr2:177043255 NA 0.8 13.0 0.58 1.74e-31 IgG glycosylation; CRC cis rs9457247 0.663 rs6456143 chr6:167415440 C/A cg07741184 chr6:167504864 NA 0.35 6.3 0.33 9.33e-10 Crohn's disease; CRC cis rs2243480 1.000 rs73142122 chr7:65311298 C/A cg12463550 chr7:65579703 CRCP 0.71 6.53 0.34 2.52e-10 Diabetic kidney disease; CRC trans rs72991 0.644 rs297486 chr11:121257399 G/A cg27192990 chr6:129479024 LAMA2 -0.36 -5.99 -0.31 5.5e-9 Response to tocilizumab in rheumatoid arthritis; CRC cis rs7309 0.935 rs10930013 chr2:162070325 G/A cg08807892 chr2:162101083 NA 0.45 6.63 0.34 1.35e-10 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Educational attainment; CRC cis rs4660306 1.000 rs10736426 chr1:45984353 A/G cg03123370 chr1:45965343 CCDC163P;MMACHC 0.52 7.56 0.38 4.17e-13 Homocysteine levels; CRC cis rs2857891 0.909 rs56261447 chr11:6939382 A/C cg22096450 chr11:6947773 ZNF215 0.58 6.01 0.31 4.99e-9 Response to cytadine analogues (cytosine arabinoside); CRC cis rs853679 0.517 rs9368554 chr6:28082711 T/C cg02683197 chr6:28174875 NA 0.85 10.27 0.49 1.16e-21 Depression; CRC cis rs3816788 0.792 rs7013323 chr8:21869024 C/G cg17168535 chr8:21777572 XPO7 0.61 10.43 0.5 3.51e-22 Lung cancer in ever smokers; CRC cis rs7769051 1.000 rs9493446 chr6:133125643 C/T cg07930552 chr6:133119739 C6orf192 0.63 7.69 0.39 1.76e-13 Type 2 diabetes nephropathy; CRC cis rs11971779 0.555 rs4728466 chr7:139096365 T/C cg07862535 chr7:139043722 LUC7L2 0.57 7.32 0.37 1.92e-12 Diisocyanate-induced asthma; CRC cis rs877282 0.898 rs36064821 chr10:760952 C/T cg06581033 chr10:766294 NA -0.51 -5.8 -0.3 1.59e-8 Uric acid levels; CRC cis rs589448 1.000 rs589448 chr12:69752200 A/G cg20891283 chr12:69753455 YEATS4 0.99 21.36 0.76 4.12e-64 Cerebrospinal fluid biomarker levels; CRC cis rs2204008 0.837 rs12370891 chr12:37984531 A/G cg26384229 chr12:38710491 ALG10B 0.69 9.14 0.45 6.75e-18 Bladder cancer; CRC trans rs4332037 0.707 rs10268797 chr7:1873756 C/G cg11693508 chr17:37793320 STARD3 -0.63 -8.03 -0.4 1.77e-14 Bipolar disorder; CRC cis rs12618769 0.543 rs2278211 chr2:99149946 G/A cg18455616 chr2:99124870 INPP4A 0.35 5.69 0.3 2.8e-8 Bipolar disorder; CRC cis rs4234798 0.500 rs7661066 chr4:7219878 C/T cg18431297 chr4:7219810 SORCS2 0.75 13.3 0.59 1.39e-32 Insulin-like growth factors; CRC cis rs6714710 0.603 rs11123974 chr2:98605982 A/G cg26665480 chr2:98280029 ACTR1B 0.53 7.3 0.37 2.24e-12 Posterior cortical atrophy and Alzheimer's disease; CRC cis rs1046896 0.594 rs9914570 chr17:80783721 C/T cg19500275 chr17:80737654 TBCD 0.49 6.52 0.34 2.68e-10 Glycated hemoglobin levels; CRC cis rs861020 0.771 rs629150 chr1:209998467 C/T cg09163369 chr1:210001066 C1orf107 0.61 8.0 0.4 2.1e-14 Orofacial clefts; CRC trans rs1973993 0.745 rs6593602 chr1:96951281 G/A cg10631902 chr5:14652156 NA -0.41 -6.82 -0.35 4.39e-11 Weight; CRC cis rs9326248 0.906 rs171052 chr11:117081763 C/G cg10130564 chr11:117069849 TAGLN -0.38 -7.0 -0.36 1.49e-11 Blood protein levels; CRC cis rs7044106 0.791 rs10985000 chr9:123484115 A/G cg09586646 chr9:123605570 PSMD5;LOC253039 0.63 9.36 0.46 1.25e-18 Hip circumference adjusted for BMI; CRC cis rs9303280 0.806 rs4795400 chr17:38067020 C/T cg11212589 chr17:38028394 ZPBP2 0.39 7.02 0.36 1.32e-11 Self-reported allergy; CRC cis rs6570726 0.967 rs373527 chr6:145801861 C/T cg23711669 chr6:146136114 FBXO30 0.63 10.64 0.51 6.56e-23 Lobe attachment (rater-scored or self-reported); CRC cis rs9733 0.596 rs17658705 chr1:150678071 A/C cg15448220 chr1:150897856 SETDB1 -0.45 -6.39 -0.33 5.62e-10 Tonsillectomy; CRC cis rs2762353 0.718 rs1165205 chr6:25870542 A/T cg12310025 chr6:25882481 NA 0.51 7.91 0.4 4.03e-14 Blood metabolite levels; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg11744295 chr1:161283833 SDHC;LOC642502 0.41 6.25 0.33 1.24e-9 Response to antipsychotic treatment; CRC cis rs10256972 0.630 rs13235747 chr7:1129123 T/C cg23708337 chr7:1209742 NA 0.44 6.51 0.34 2.78e-10 Longevity;Endometriosis; CRC cis rs67478160 0.643 rs8003653 chr14:104298836 A/G cg08213375 chr14:104286397 PPP1R13B 0.63 13.29 0.59 1.49e-32 Schizophrenia; CRC cis rs9916302 0.706 rs6503500 chr17:37485925 C/T cg00129232 chr17:37814104 STARD3 -0.55 -6.92 -0.36 2.31e-11 Glomerular filtration rate (creatinine); CRC cis rs67311347 1.000 rs9857824 chr3:40459412 A/G cg24209194 chr3:40518798 ZNF619 0.44 6.46 0.34 3.77e-10 Renal cell carcinoma; CRC trans rs17136627 0.661 rs4705669 chr5:113823916 A/T cg24528350 chr1:77384892 ST6GALNAC5 -0.48 -6.0 -0.31 5.2e-9 Coronary arterial lesions in patients with Kawasaki disease; CRC cis rs2073499 0.935 rs28365992 chr3:50340996 T/C cg09545109 chr3:50388910 TUSC4;CYB561D2 0.62 5.64 0.3 3.66e-8 Schizophrenia; CRC cis rs4862750 0.872 rs10027252 chr4:187873462 T/G cg07414643 chr4:187882934 NA 0.37 6.33 0.33 8.1e-10 Lobe attachment (rater-scored or self-reported); CRC cis rs2952156 0.920 rs1018246 chr17:37835240 C/T cg07936489 chr17:37558343 FBXL20 -0.4 -5.72 -0.3 2.37e-8 Asthma; CRC cis rs1341267 0.529 rs6492720 chr13:95256305 T/C cg18412871 chr13:95254051 GPR180 -0.55 -7.71 -0.39 1.52e-13 Triglyceride levels; CRC cis rs116095464 0.558 rs10068203 chr5:206618 C/T cg22857025 chr5:266934 NA -1.14 -11.87 -0.55 2.78e-27 Breast cancer; CRC cis rs10901296 0.588 rs12003046 chr9:133741626 T/C cg01000188 chr9:133769184 QRFP 0.6 7.43 0.38 9.44e-13 Bilirubin levels; CRC cis rs7587476 0.954 rs3768708 chr2:215645046 C/T cg04004882 chr2:215674386 BARD1 -0.49 -6.63 -0.34 1.39e-10 Neuroblastoma; CRC cis rs9443645 0.869 rs9343827 chr6:79501036 A/G cg09184832 chr6:79620586 NA -0.48 -8.99 -0.44 2.01e-17 Intelligence (multi-trait analysis); CRC cis rs875971 0.522 rs1917563 chr7:65415647 C/T cg11764359 chr7:65958608 NA -0.52 -7.99 -0.4 2.33e-14 Aortic root size; CRC cis rs9527 0.590 rs763914 chr10:104841587 T/C cg04362960 chr10:104952993 NT5C2 0.58 8.11 0.41 1.04e-14 Arsenic metabolism; CRC cis rs6988985 0.728 rs5303 chr8:143955095 A/G cg10324643 chr8:143916377 GML 0.37 6.08 0.32 3.29e-9 Plasma androstenedione levels in resected early stage-receptor positive breast cancer; CRC cis rs929354 1.000 rs1182414 chr7:157058363 G/A cg16102536 chr7:156981717 UBE3C -0.37 -6.26 -0.33 1.21e-9 Body mass index; CRC cis rs826838 0.967 rs1684411 chr12:39128494 C/T cg26384229 chr12:38710491 ALG10B -0.64 -9.71 -0.47 9.26e-20 Heart rate; CRC cis rs1348850 0.831 rs7606235 chr2:178401288 T/C cg22681709 chr2:178499509 PDE11A -0.4 -7.23 -0.37 3.38e-12 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs4665809 1.000 rs2891490 chr2:26325927 T/C cg27170947 chr2:26402098 FAM59B -0.46 -6.11 -0.32 2.85e-9 Gut microbiome composition (summer); CRC cis rs10971721 0.822 rs72727336 chr9:33931793 G/A cg13495928 chr9:33750294 PRSS3 0.56 5.95 0.31 6.96e-9 Body mass index; CRC cis rs8040855 0.579 rs6496797 chr15:85726855 T/C cg04831495 chr15:85060580 GOLGA6L5 0.4 6.19 0.32 1.83e-9 Bulimia nervosa; CRC cis rs4665809 0.941 rs11126336 chr2:26245931 C/T cg25036284 chr2:26402008 FAM59B -0.45 -5.73 -0.3 2.22e-8 Gut microbiome composition (summer); CRC trans rs116095464 0.558 rs10462755 chr5:246748 T/C cg00938859 chr5:1591904 SDHAP3 0.73 7.76 0.39 1.07e-13 Breast cancer; CRC cis rs208520 0.690 rs12213561 chr6:66705646 T/C cg07460842 chr6:66804631 NA 1.04 14.64 0.63 1.04e-37 Exhaled nitric oxide output; CRC cis rs807029 0.533 rs12571302 chr10:102742763 C/A cg04662943 chr10:102668895 NA 0.65 7.45 0.38 8.54e-13 Ejection fraction in Tripanosoma cruzi seropositivity; CRC cis rs11214589 1.000 rs11214589 chr11:113245048 C/T cg14159747 chr11:113255604 NA 0.56 10.82 0.51 1.49e-23 Neuroticism; CRC cis rs60871478 1.000 rs34260834 chr7:822958 A/G cg04727924 chr7:799746 HEATR2 -0.41 -6.17 -0.32 2.02e-9 Cerebrospinal P-tau181p levels; CRC cis rs2075371 1.000 rs2241336 chr7:133979578 A/G cg02659138 chr7:134003124 SLC35B4 0.39 6.85 0.35 3.59e-11 Mean platelet volume; CRC cis rs7537052 0.646 rs6680302 chr1:36653540 C/T cg25304816 chr1:36627734 MAP7D1 0.42 6.71 0.35 8.53e-11 Schizophrenia; CRC cis rs703842 0.560 rs11533604 chr12:58047713 G/A cg15848620 chr12:58087721 OS9 0.53 6.16 0.32 2.08e-9 Multiple sclerosis; CRC cis rs4423214 0.559 rs10898201 chr11:71201527 C/A cg05163923 chr11:71159392 DHCR7 -0.58 -5.9 -0.31 8.93e-9 Vitamin D levels; CRC cis rs2836974 0.965 rs34578707 chr21:40675167 G/A cg17971929 chr21:40555470 PSMG1 0.71 9.7 0.47 9.66e-20 Cognitive function; CRC cis rs7258465 1.000 rs4808801 chr19:18571141 A/G cg06462663 chr19:18546047 ISYNA1 0.45 6.61 0.34 1.53e-10 Breast cancer; CRC cis rs7552404 1.000 rs7518038 chr1:76154430 G/A cg03433033 chr1:76189801 ACADM 0.82 11.35 0.53 2.04e-25 Blood metabolite levels;Acylcarnitine levels; CRC cis rs7584330 0.554 rs74001383 chr2:238424418 T/C cg14458575 chr2:238380390 NA 0.44 6.3 0.33 9.77e-10 Prostate cancer; CRC cis rs2404602 0.692 rs35999717 chr15:77193367 G/C cg22467129 chr15:76604101 ETFA -0.38 -6.06 -0.32 3.76e-9 Blood metabolite levels; CRC cis rs1044826 0.597 rs6803593 chr3:139193987 T/C cg00490450 chr3:139108681 COPB2 0.44 6.59 0.34 1.79e-10 Obesity-related traits; CRC cis rs4862750 0.872 rs9997374 chr4:187877549 T/A cg27532560 chr4:187881888 NA -0.55 -10.12 -0.49 3.82e-21 Lobe attachment (rater-scored or self-reported); CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg07190229 chr8:142377361 GPR20 0.46 6.31 0.33 9.21e-10 Thyroid stimulating hormone; CRC cis rs2842992 0.789 rs4709370 chr6:160210061 A/G cg19482086 chr6:160211437 TCP1;MRPL18 0.74 9.74 0.47 7.25e-20 Age-related macular degeneration (geographic atrophy); CRC cis rs11608355 0.521 rs10850131 chr12:109837052 A/G cg19025524 chr12:109796872 NA 0.57 9.13 0.45 7.16e-18 Neuroticism; CRC cis rs311392 0.554 rs2671798 chr8:55104495 C/T cg06042504 chr8:55087323 NA -0.36 -5.72 -0.3 2.45e-8 Pelvic organ prolapse (moderate/severe); CRC cis rs1552244 0.816 rs17050701 chr3:10041554 A/G cg16606324 chr3:10149918 C3orf24 0.62 8.08 0.41 1.25e-14 Alzheimer's disease; CRC cis rs9733 0.566 rs878471 chr1:150547747 G/A cg18016565 chr1:150552671 MCL1 -0.49 -7.78 -0.39 9.4e-14 Tonsillectomy; CRC trans rs1737890 0.778 rs6119241 chr20:30929095 G/T cg05428433 chr16:3614067 NLRC3 0.39 5.97 0.31 6.08e-9 Chronic obstructive pulmonary disease; CRC trans rs6788895 1.000 rs6769917 chr3:150509604 A/T cg03041920 chr13:100310311 CLYBL 0.62 5.97 0.31 6.12e-9 Breast cancer; CRC cis rs11792861 0.926 rs3750451 chr9:111822866 C/T cg05043794 chr9:111880884 C9orf5 -0.37 -6.71 -0.35 8.64e-11 Menarche (age at onset); CRC trans rs9467711 0.790 rs35162296 chr6:26318262 C/T cg06606381 chr12:133084897 FBRSL1 -0.95 -6.8 -0.35 4.91e-11 Autism spectrum disorder or schizophrenia; CRC cis rs9916302 0.904 rs600010 chr17:37433517 T/C cg07936489 chr17:37558343 FBXL20 -0.79 -11.79 -0.55 5.24e-27 Glomerular filtration rate (creatinine); CRC cis rs2440129 0.632 rs2292353 chr17:6903537 C/T cg03407747 chr17:6899364 ALOX12 0.59 10.72 0.51 3.35e-23 Tonsillectomy; CRC cis rs11148252 0.538 rs2274202 chr13:52722798 C/A cg12458913 chr13:53173898 NA 0.48 7.16 0.37 5.41e-12 Lewy body disease; CRC cis rs7618915 0.547 rs12486847 chr3:52691112 T/C cg11645453 chr3:52864694 ITIH4 0.37 6.41 0.33 4.91e-10 Bipolar disorder; CRC cis rs7618915 1.000 rs3852064 chr3:52349412 G/T cg18099408 chr3:52552593 STAB1 -0.42 -6.41 -0.33 4.95e-10 Bipolar disorder; CRC cis rs6502050 0.814 rs62079997 chr17:80076888 C/T cg22110888 chr17:80059540 CCDC57 -0.42 -6.62 -0.34 1.48e-10 Life satisfaction; CRC cis rs926938 0.527 rs11084 chr1:115537933 A/G cg12756093 chr1:115239321 AMPD1 0.47 6.91 0.36 2.45e-11 Autism; CRC trans rs9354308 0.933 rs2802062 chr6:66561973 C/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.47 5.99 0.31 5.47e-9 Metabolite levels; CRC cis rs1692580 0.840 rs262679 chr1:2169792 C/T cg24578937 chr1:2090814 PRKCZ 0.44 7.83 0.4 6.99e-14 Coronary artery disease; CRC cis rs1862618 0.853 rs1423620 chr5:56100996 G/T cg24531977 chr5:56204891 C5orf35 -0.75 -9.83 -0.48 3.67e-20 Initial pursuit acceleration; CRC cis rs76878669 0.606 rs1785639 chr11:66100430 G/A cg24851651 chr11:66362959 CCS -0.35 -6.03 -0.32 4.45e-9 Educational attainment (years of education); CRC cis rs10256972 0.591 rs6968988 chr7:1169619 A/G cg09177884 chr7:1199841 ZFAND2A -0.42 -6.24 -0.33 1.35e-9 Longevity;Endometriosis; CRC cis rs798554 0.757 rs1713919 chr7:2864706 C/A cg14895029 chr7:2775587 GNA12 -0.44 -6.45 -0.34 3.95e-10 Height; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg10354764 chr16:3285464 ZNF200 0.49 6.4 0.33 5.46e-10 Thyroid stimulating hormone; CRC cis rs4713118 0.513 rs149944 chr6:28002818 C/T cg03623178 chr6:28175578 NA 0.75 11.35 0.53 2.11e-25 Parkinson's disease; CRC cis rs11608355 0.538 rs12228876 chr12:109796799 C/A cg19025524 chr12:109796872 NA -0.62 -10.1 -0.49 4.61e-21 Neuroticism; CRC cis rs10971721 0.822 rs10971755 chr9:33872005 C/T cg13495928 chr9:33750294 PRSS3 0.56 5.95 0.31 6.96e-9 Body mass index; CRC cis rs11212617 0.967 rs11212635 chr11:108310702 T/A cg01991180 chr11:108092276 ATM;NPAT -0.4 -5.77 -0.3 1.8e-8 Response to metformin in type 2 diabetes (glycemic); CRC cis rs17539620 0.624 rs62432739 chr6:154835926 A/G cg20019720 chr6:154832845 CNKSR3 0.5 8.21 0.41 5.03e-15 Lipoprotein (a) levels; CRC cis rs939658 0.805 rs12902831 chr15:79433171 G/A cg17916960 chr15:79447300 NA -0.46 -7.45 -0.38 8.4e-13 Refractive error; CRC cis rs1552244 1.000 rs7615646 chr3:10089773 A/C cg10729496 chr3:10149963 C3orf24 0.55 7.26 0.37 2.73e-12 Alzheimer's disease; CRC cis rs780096 0.546 rs1528533 chr2:27595756 G/C cg12000995 chr2:27665139 KRTCAP3 -0.3 -6.3 -0.33 9.69e-10 Total body bone mineral density; CRC cis rs7615952 0.599 rs6766327 chr3:125723677 C/G cg02807482 chr3:125708958 NA -0.46 -5.95 -0.31 6.78e-9 Blood pressure (smoking interaction); CRC cis rs4750440 0.736 rs4748070 chr10:14031388 G/A cg00551146 chr10:14014579 FRMD4A 0.37 5.96 0.31 6.63e-9 Adiponectin levels; CRC cis rs68170813 0.559 rs77185844 chr7:106812916 A/C cg02696742 chr7:106810147 HBP1 -0.62 -6.83 -0.35 4.17e-11 Coronary artery disease; CRC cis rs7666738 0.927 rs6832373 chr4:99051967 A/G cg05340658 chr4:99064831 C4orf37 0.6 9.15 0.45 6.17e-18 Colonoscopy-negative controls vs population controls; CRC cis rs1816752 0.819 rs4769349 chr13:24982832 A/G cg02811702 chr13:24901961 NA -0.4 -5.63 -0.3 3.86e-8 Obesity-related traits; CRC cis rs7312933 0.576 rs11181364 chr12:42567800 C/T cg19980929 chr12:42632907 YAF2 0.45 6.6 0.34 1.63e-10 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CRC cis rs7772486 0.875 rs7767660 chr6:146436550 T/C cg23711669 chr6:146136114 FBXO30 0.63 10.74 0.51 2.96e-23 Lobe attachment (rater-scored or self-reported); CRC cis rs7973719 1.000 rs12828421 chr12:7335217 C/T cg07052231 chr12:7363540 PEX5 -0.48 -7.82 -0.4 7.42e-14 IgG glycosylation; CRC cis rs9368481 0.761 rs7775041 chr6:27009512 T/A cg05192639 chr6:26864778 GUSBL1 -0.33 -5.77 -0.3 1.82e-8 Autism spectrum disorder or schizophrenia; CRC cis rs9443645 0.901 rs9352669 chr6:79584141 T/G cg11833968 chr6:79620685 NA -0.36 -6.26 -0.33 1.23e-9 Intelligence (multi-trait analysis); CRC cis rs9372498 0.536 rs62424199 chr6:118827252 G/A cg10217327 chr6:118973057 C6orf204 0.52 5.9 0.31 9e-9 Diastolic blood pressure; CRC cis rs7264396 0.563 rs2425086 chr20:34302873 G/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.48 -6.67 -0.35 1.06e-10 Total cholesterol levels; CRC trans rs61931739 0.500 rs7310576 chr12:34474735 T/C cg26384229 chr12:38710491 ALG10B 0.6 8.58 0.43 3.78e-16 Morning vs. evening chronotype; CRC cis rs1046896 0.553 rs3744160 chr17:80828303 G/A cg02711726 chr17:80685570 FN3KRP -0.51 -6.87 -0.35 3.19e-11 Glycated hemoglobin levels; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg05596267 chr15:34331198 CHRM5;AVEN 0.38 6.33 0.33 8.07e-10 Liver disease severity in Alagille syndrome; CRC cis rs524281 0.861 rs10896094 chr11:65959206 C/T cg14036092 chr11:66035641 RAB1B -0.47 -5.71 -0.3 2.54e-8 Electroencephalogram traits; CRC cis rs870825 0.616 rs6552810 chr4:185644143 G/A cg04058563 chr4:185651563 MLF1IP 0.72 9.42 0.46 8.15e-19 Blood protein levels; CRC cis rs2668423 0.922 rs3826942 chr19:1360575 A/G cg02639931 chr19:1387894 NDUFS7 0.69 10.37 0.5 5.49e-22 Nonalcoholic fatty liver disease; CRC cis rs9811920 0.638 rs1688782 chr3:99630527 C/G cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G -0.47 -6.49 -0.34 3.14e-10 Axial length; CRC cis rs3820068 0.581 rs1122386 chr1:15946877 C/T cg13390004 chr1:15929781 NA 0.5 7.11 0.37 7.21e-12 Systolic blood pressure; CRC cis rs2404602 0.647 rs12914196 chr15:76941361 C/T cg03037974 chr15:76606532 NA -0.51 -7.27 -0.37 2.71e-12 Blood metabolite levels; CRC trans rs4853036 0.586 rs7558899 chr2:70010351 T/C cg14633329 chr9:139640053 LCN6 -0.39 -6.44 -0.33 4.31e-10 Colorectal or endometrial cancer; CRC trans rs1005277 0.505 rs13503 chr10:38239843 C/A cg23533926 chr12:111358616 MYL2 0.46 6.67 0.35 1.1e-10 Extrinsic epigenetic age acceleration; CRC cis rs2251381 0.750 rs2255055 chr21:30537045 C/T cg24692254 chr21:30365293 RNF160 0.71 11.88 0.55 2.45e-27 Selective IgA deficiency; CRC cis rs10089 1.000 rs1962291 chr5:127445373 A/G cg25462716 chr5:127418816 SLC12A2;FLJ33630 -0.74 -10.34 -0.5 7.13e-22 Ileal carcinoids; CRC cis rs514406 0.893 rs479569 chr1:53352407 C/T cg27535305 chr1:53392650 SCP2 -0.38 -6.74 -0.35 6.95e-11 Monocyte count; CRC cis rs2576037 0.526 rs2156050 chr18:44455873 A/G cg23996704 chr18:44553084 KATNAL2 -0.35 -7.29 -0.37 2.35e-12 Personality dimensions; CRC cis rs12142240 0.698 rs17357621 chr1:46807697 C/T cg14993813 chr1:46806288 NSUN4 -0.49 -6.22 -0.32 1.5e-9 Menopause (age at onset); CRC cis rs72730918 0.564 rs6493511 chr15:51901605 A/G cg14296394 chr15:51910925 DMXL2 -0.46 -6.0 -0.31 5.18e-9 Intelligence (multi-trait analysis); CRC cis rs995000 0.899 rs1168032 chr1:62967747 A/G cg19896129 chr1:63156450 NA -0.39 -6.08 -0.32 3.29e-9 Triglyceride levels; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg10403048 chr19:15490832 AKAP8 0.49 6.29 0.33 1.01e-9 Thyroid stimulating hormone; CRC cis rs1552244 0.935 rs7618815 chr3:10151045 A/G cg02579736 chr3:10068473 FANCD2;CIDECP 1.04 13.81 0.61 1.49e-34 Alzheimer's disease; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg17408923 chr2:109335769 RANBP2 0.44 6.37 0.33 6.21e-10 Intelligence (multi-trait analysis); CRC cis rs950776 0.684 rs61012457 chr15:78865694 C/G cg06917634 chr15:78832804 PSMA4 0.61 8.87 0.44 4.71e-17 Sudden cardiac arrest; CRC cis rs3858526 0.584 rs10734560 chr11:5864503 G/T cg13902645 chr11:5959945 NA -0.66 -9.34 -0.46 1.53e-18 DNA methylation (variation); CRC cis rs11971779 0.648 rs6467849 chr7:139080512 C/G cg07862535 chr7:139043722 LUC7L2 0.57 7.35 0.38 1.61e-12 Diisocyanate-induced asthma; CRC cis rs7216064 1.000 rs2128792 chr17:65857177 C/T cg12091567 chr17:66097778 LOC651250 -0.68 -7.81 -0.4 7.5e-14 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CRC cis rs2549003 1.000 rs9282761 chr5:131822224 T/C cg00255919 chr5:131827918 IRF1 0.59 11.92 0.55 1.77e-27 Asthma (sex interaction); CRC trans rs2727020 0.894 rs1880438 chr11:49370698 A/G cg03929089 chr4:120376271 NA -0.71 -9.34 -0.46 1.48e-18 Coronary artery disease; CRC cis rs7666738 0.830 rs11722272 chr4:99000839 C/T cg05340658 chr4:99064831 C4orf37 0.61 9.35 0.46 1.36e-18 Colonoscopy-negative controls vs population controls; CRC cis rs10504229 0.861 rs59873610 chr8:58172290 T/A cg02290350 chr8:58132656 NA -0.42 -5.96 -0.31 6.42e-9 Developmental language disorder (linguistic errors); CRC cis rs10504229 0.593 rs78459635 chr8:58004995 G/T cg24829409 chr8:58192753 C8orf71 -0.53 -6.39 -0.33 5.79e-10 Developmental language disorder (linguistic errors); CRC cis rs425277 0.958 rs262687 chr1:2117155 G/A cg24578937 chr1:2090814 PRKCZ 0.66 11.33 0.53 2.44e-25 Height; CRC cis rs6499255 0.904 rs7194753 chr16:69564364 A/G cg15192750 chr16:69999425 NA -0.47 -6.4 -0.33 5.38e-10 IgE levels; CRC cis rs7666738 0.822 rs13110418 chr4:99046963 G/A cg17366294 chr4:99064904 C4orf37 0.45 7.75 0.39 1.16e-13 Colonoscopy-negative controls vs population controls; CRC cis rs2290159 0.800 rs73132351 chr3:12688284 A/G cg23032965 chr3:12705835 RAF1 0.44 6.09 0.32 3.24e-9 Cholesterol, total; CRC cis rs2243480 1.000 rs316315 chr7:65591205 C/T cg18252515 chr7:66147081 NA 0.98 12.83 0.58 7.84e-31 Diabetic kidney disease; CRC cis rs875971 0.862 rs4236208 chr7:65749078 C/T cg18876405 chr7:65276391 NA -0.5 -8.29 -0.42 2.87e-15 Aortic root size; CRC cis rs7772486 0.720 rs4896844 chr6:146075224 T/C cg13319975 chr6:146136371 FBXO30 0.46 6.85 0.35 3.63e-11 Lobe attachment (rater-scored or self-reported); CRC cis rs7904368 0.754 rs7076779 chr10:16852667 C/T cg14835575 chr10:16859367 RSU1 0.48 6.6 0.34 1.65e-10 Ratio of the peak velocity of the mitral E-Wave divided by the peak velocity of the mitral A-wave.; CRC cis rs1865760 0.713 rs7766342 chr6:25990674 C/A cg18357526 chr6:26021779 HIST1H4A 0.41 5.99 0.31 5.36e-9 Height; CRC cis rs4478858 0.735 rs6687819 chr1:31801112 G/A cg00250761 chr1:31883323 NA -0.44 -8.5 -0.42 6.71e-16 Alcohol dependence; CRC cis rs75920871 0.528 rs11216245 chr11:116913202 C/T cg01368799 chr11:117014884 PAFAH1B2 -0.4 -5.74 -0.3 2.18e-8 Subjective well-being; CRC cis rs7666738 0.830 rs60007031 chr4:98824753 G/C cg05340658 chr4:99064831 C4orf37 0.53 7.69 0.39 1.72e-13 Colonoscopy-negative controls vs population controls; CRC cis rs10504073 0.647 rs12546839 chr8:50009020 C/T cg00325661 chr8:49890786 NA 0.53 9.5 0.46 4.66e-19 Blood metabolite ratios; CRC cis rs7618915 0.501 rs2164885 chr3:52731269 T/C cg15147215 chr3:52552868 STAB1 -0.62 -10.5 -0.5 1.96e-22 Bipolar disorder; CRC cis rs34779708 0.750 rs35032841 chr10:35312687 G/A cg03585969 chr10:35415529 CREM 0.65 8.78 0.44 9.01e-17 Inflammatory bowel disease;Crohn's disease; CRC cis rs7666738 0.830 rs62318504 chr4:98935558 T/G cg05340658 chr4:99064831 C4orf37 0.6 9.35 0.46 1.41e-18 Colonoscopy-negative controls vs population controls; CRC cis rs11785400 0.793 rs9774627 chr8:143731267 G/A cg24634471 chr8:143751801 JRK 0.52 7.15 0.37 5.69e-12 Schizophrenia; CRC cis rs4481887 0.893 rs10788763 chr1:248429070 A/T cg13385794 chr1:248469461 NA -0.38 -6.87 -0.35 3.27e-11 Common traits (Other); CRC cis rs12325245 0.536 rs12931124 chr16:58620063 G/A cg26666090 chr16:58549219 SETD6 0.95 6.49 0.34 3.24e-10 Schizophrenia; CRC cis rs2777491 1.000 rs7168177 chr15:41715585 A/G cg18705301 chr15:41695430 NDUFAF1 -0.74 -12.69 -0.57 2.61e-30 Ulcerative colitis; CRC cis rs4713118 0.629 rs203890 chr6:28022248 T/C cg15845792 chr6:28175446 NA 0.95 13.94 0.61 5.13e-35 Parkinson's disease; CRC cis rs7224685 0.501 rs781827 chr17:3962965 G/A cg11204139 chr17:3907470 NA 0.75 14.31 0.62 1.86e-36 Type 2 diabetes; CRC cis rs589448 0.967 rs634512 chr12:69754012 C/T cg14784868 chr12:69753453 YEATS4 0.91 17.74 0.7 6.87e-50 Cerebrospinal fluid biomarker levels; CRC cis rs28386778 0.897 rs2584626 chr17:61903179 A/G cg25654072 chr17:61904446 PSMC5;FTSJ3 0.72 11.25 0.53 4.67e-25 Prudent dietary pattern; CRC cis rs763121 0.626 rs5750643 chr22:39009017 A/G cg06022373 chr22:39101656 GTPBP1 0.8 13.41 0.59 4.99e-33 Menopause (age at onset); CRC cis rs7727544 1.000 rs10076701 chr5:131596419 A/G cg20512303 chr5:131592959 PDLIM4 0.29 5.83 0.31 1.35e-8 Blood metabolite levels; CRC cis rs780096 0.565 rs780104 chr2:27677691 G/A cg17158414 chr2:27665306 KRTCAP3 -0.3 -6.68 -0.35 9.98e-11 Total body bone mineral density; CRC cis rs2243480 1.000 rs34703416 chr7:65300642 A/G cg18252515 chr7:66147081 NA -1.17 -13.55 -0.6 1.59e-33 Diabetic kidney disease; CRC cis rs7089973 0.584 rs758585 chr10:116582560 C/A cg23260525 chr10:116636907 FAM160B1 0.4 9.35 0.46 1.38e-18 Bipolar disorder or attention deficit hyperactivity disorder; CRC cis rs1577917 0.652 rs75593931 chr6:86719539 A/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.53 -6.64 -0.34 1.32e-10 Response to antipsychotic treatment; CRC cis rs3749237 0.595 rs1568661 chr3:49520958 A/G cg02487422 chr3:49467188 NICN1 0.41 6.7 0.35 8.99e-11 Resting heart rate; CRC cis rs4728302 0.869 rs2042455 chr7:133580545 A/G cg03336402 chr7:133662267 EXOC4 -0.43 -6.15 -0.32 2.23e-9 Intelligence;Intelligence (multi-trait analysis); CRC cis rs3771570 0.901 rs35496488 chr2:242434316 G/A cg21155796 chr2:242212141 HDLBP 0.64 6.84 0.35 3.88e-11 Prostate cancer; CRC cis rs2580764 0.678 rs2580765 chr2:55204028 A/C cg09592903 chr2:55203963 RTN4 0.78 12.38 0.56 3.84e-29 Mean platelet volume; CRC cis rs10256972 0.568 rs1133043 chr7:1133305 C/G cg18765753 chr7:1198926 ZFAND2A -0.37 -6.28 -0.33 1.09e-9 Longevity;Endometriosis; CRC cis rs12760731 0.623 rs6688546 chr1:178332511 A/G cg00404053 chr1:178313656 RASAL2 0.75 9.45 0.46 6.51e-19 Obesity-related traits; CRC cis rs10883723 0.810 rs6584508 chr10:104258567 A/G cg22532475 chr10:104410764 TRIM8 -0.36 -6.67 -0.35 1.06e-10 Allergic disease (asthma, hay fever or eczema); CRC cis rs11758351 0.925 rs2183948 chr6:26180332 A/G cg22723502 chr6:26240528 HIST1H4F -0.39 -6.21 -0.32 1.58e-9 Gout;Renal underexcretion gout; CRC cis rs4654899 0.931 rs6661116 chr1:21337155 C/G cg02927042 chr1:21476669 EIF4G3 -0.48 -7.76 -0.39 1.09e-13 Superior frontal gyrus grey matter volume; CRC cis rs6545883 1.000 rs778763 chr2:61785639 C/G cg15711740 chr2:61764176 XPO1 -0.52 -7.16 -0.37 5.28e-12 Tuberculosis; CRC cis rs933688 1.000 rs61612071 chr5:90741470 G/A cg02339078 chr5:90679543 LOC100129716;ARRDC3 0.88 13.58 0.6 1.14e-33 Smoking behavior; CRC cis rs9894429 0.682 rs7406360 chr17:79591545 G/A cg21028142 chr17:79581711 NPLOC4 0.33 6.97 0.36 1.77e-11 Eye color traits; CRC cis rs8180040 0.966 rs13072802 chr3:47346415 G/C cg10298567 chr3:47292165 KIF9 -0.39 -6.59 -0.34 1.73e-10 Colorectal cancer; CRC cis rs709400 0.628 rs6575984 chr14:103876454 A/G cg12935359 chr14:103987150 CKB 0.52 8.4 0.42 1.38e-15 Body mass index; CRC cis rs62408225 0.894 rs62408218 chr6:90931858 C/T cg06866423 chr6:90926672 BACH2 0.45 7.16 0.37 5.23e-12 Eosinophil counts;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC cis rs6429082 0.755 rs291370 chr1:235693041 A/G cg26050004 chr1:235667680 B3GALNT2 0.59 8.74 0.43 1.21e-16 Adiposity; CRC cis rs13108904 0.870 rs13115355 chr4:1261576 G/A cg02018176 chr4:1364513 KIAA1530 0.45 7.43 0.38 9.58e-13 Obesity-related traits; CRC cis rs7937682 0.883 rs529529 chr11:111461128 C/T cg09085632 chr11:111637200 PPP2R1B -0.94 -17.74 -0.7 7.01e-50 Primary sclerosing cholangitis; CRC cis rs537930 0.560 rs2431151 chr5:134348225 G/T cg24576358 chr5:134350122 NA 0.32 5.64 0.3 3.58e-8 Height; CRC cis rs6543140 0.964 rs10200081 chr2:103091556 T/C cg04239558 chr2:103089729 SLC9A4 0.38 6.65 0.34 1.25e-10 Blood protein levels; CRC cis rs2976388 1.000 rs1045605 chr8:143764101 C/G cg04969067 chr8:143858791 LYNX1 -0.36 -6.08 -0.32 3.39e-9 Urinary tract infection frequency; CRC trans rs7618501 0.665 rs7621352 chr3:50070763 A/C cg21665057 chr3:196295764 WDR53;FBXO45 -0.62 -9.8 -0.48 4.62e-20 Intelligence (multi-trait analysis); CRC cis rs6502050 0.835 rs8079389 chr17:80158656 T/G cg02741985 chr17:80059408 CCDC57 0.44 7.24 0.37 3.13e-12 Life satisfaction; CRC trans rs7726839 0.574 rs72707007 chr5:661856 T/C cg25482853 chr8:67687455 SGK3 1.12 13.12 0.59 6.41e-32 Obesity-related traits; CRC cis rs7762018 0.607 rs80106119 chr6:170048309 T/C cg24289452 chr6:170231220 NA -0.94 -7.59 -0.39 3.43e-13 Thiazide-induced adverse metabolic effects in hypertensive patients; CRC cis rs896854 0.516 rs12679044 chr8:95891356 C/A cg13393036 chr8:95962371 TP53INP1 -0.44 -7.0 -0.36 1.49e-11 Type 2 diabetes; CRC cis rs3936840 0.861 rs1044502 chr14:102965897 G/A cg18135206 chr14:102964638 TECPR2 0.53 7.04 0.36 1.15e-11 Plateletcrit; CRC cis rs4478858 0.602 rs4949370 chr1:31723889 G/C cg00250761 chr1:31883323 NA -0.33 -6.14 -0.32 2.4e-9 Alcohol dependence; CRC cis rs3806843 0.966 rs7737424 chr5:140146345 C/T cg16607685 chr5:140181889 PCDHA2;PCDHA1;PCDHA3 -0.26 -5.99 -0.31 5.59e-9 Depressive symptoms (multi-trait analysis); CRC cis rs4780401 0.632 rs8055462 chr16:11834821 T/C cg01061890 chr16:11836724 TXNDC11 -0.62 -9.06 -0.45 1.22e-17 Rheumatoid arthritis; CRC trans rs2163503 0.691 rs847734 chr1:71438092 T/A cg23933503 chr22:44255884 SULT4A1 -0.42 -6.19 -0.32 1.78e-9 Intelligence (multi-trait analysis); CRC cis rs2153535 0.541 rs4637688 chr6:8446501 A/G cg21535247 chr6:8435926 SLC35B3 0.5 7.48 0.38 6.67e-13 Motion sickness; CRC cis rs2857078 0.654 rs4793083 chr17:42312973 C/T cg19774624 chr17:42201019 HDAC5 0.41 5.96 0.31 6.57e-9 Red cell distribution width;Reticulocyte count; CRC cis rs7605827 0.930 rs6749663 chr2:15529705 T/G cg19274914 chr2:15703543 NA 0.38 5.75 0.3 2.01e-8 Educational attainment (years of education); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg06766450 chr1:16766999 NECAP2 0.49 6.94 0.36 2.07e-11 Response to antipsychotic treatment; CRC cis rs12410462 0.579 rs115037090 chr1:227666191 A/G cg04117972 chr1:227635322 NA 0.83 8.32 0.42 2.36e-15 Major depressive disorder; CRC cis rs7666738 0.830 rs62321598 chr4:99014237 C/T cg05340658 chr4:99064831 C4orf37 0.61 9.54 0.47 3.43e-19 Colonoscopy-negative controls vs population controls; CRC cis rs3106136 0.527 rs4235050 chr4:95157156 A/G cg11021082 chr4:95130006 SMARCAD1 -0.6 -9.53 -0.47 3.64e-19 Capecitabine sensitivity; CRC cis rs561341 1.000 rs555629 chr17:30294136 T/C cg23018236 chr17:30244563 NA -0.65 -7.78 -0.39 9.41e-14 Hip circumference adjusted for BMI; CRC cis rs582297 1 rs582297 chr11:108165407 C/G cg12106634 chr11:108092400 ATM;NPAT 0.42 6.07 0.32 3.56e-9 Eosinophil counts;Eosinophil percentage of white cells;Sum eosinophil basophil counts; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg09696331 chr12:510665 CCDC77 0.46 6.91 0.36 2.6e-11 Liver disease severity in Alagille syndrome; CRC cis rs1552244 0.832 rs67145301 chr3:10197314 G/A cg18598329 chr3:10140678 FANCD2;C3orf24 -0.82 -9.19 -0.45 4.55e-18 Alzheimer's disease; CRC cis rs17270561 0.583 rs7749149 chr6:25781139 G/A cg17691542 chr6:26056736 HIST1H1C 0.62 8.17 0.41 6.6e-15 Iron status biomarkers; CRC cis rs2952156 0.684 rs1877031 chr17:37814080 G/A cg15445000 chr17:37608096 MED1 0.27 5.95 0.31 7.05e-9 Asthma; CRC cis rs9292777 0.814 rs6873829 chr5:40418264 T/G cg09067459 chr5:40385259 NA 0.53 9.25 0.45 3.02e-18 Crohn's disease;Multiple sclerosis; CRC cis rs698833 0.859 rs786612 chr2:44600819 G/C cg04920474 chr2:44395004 PPM1B 0.42 6.11 0.32 2.79e-9 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; CRC cis rs2032447 0.765 rs1935235 chr6:26067782 C/G cg12310025 chr6:25882481 NA -0.5 -6.94 -0.36 2.06e-11 Intelligence (multi-trait analysis); CRC trans rs2305707 0.544 rs34080711 chr15:51561456 G/A cg02146857 chr19:18901748 COMP 0.5 5.97 0.31 6.03e-9 Height; CRC trans rs17685 0.623 rs7782808 chr7:75768645 C/T cg19862616 chr7:65841803 NCRNA00174 0.99 18.11 0.71 2.51e-51 Coffee consumption;Coffee consumption (cups per day); CRC cis rs7208859 0.623 rs2035494 chr17:29130393 T/G cg13385521 chr17:29058706 SUZ12P 0.74 8.44 0.42 9.97e-16 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs6693567 0.565 rs1260457 chr1:150347374 G/A cg15654264 chr1:150340011 RPRD2 0.42 6.4 0.33 5.48e-10 Migraine; CRC cis rs9399137 0.507 rs7771310 chr6:135272535 G/A cg24558204 chr6:135376177 HBS1L 0.63 9.09 0.45 9.45e-18 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; CRC cis rs10781543 0.845 rs10781540 chr9:139321836 G/A cg14019695 chr9:139328340 INPP5E 0.42 6.18 0.32 1.91e-9 Monocyte percentage of white cells; CRC cis rs9916302 0.861 rs11078896 chr17:37415544 C/T cg15445000 chr17:37608096 MED1 0.41 8.88 0.44 4.53e-17 Glomerular filtration rate (creatinine); CRC cis rs9826463 0.818 rs9858204 chr3:142299855 C/T cg20824294 chr3:142316082 PLS1 0.32 5.78 0.3 1.71e-8 QRS duration in Tripanosoma cruzi seropositivity; CRC cis rs4285028 0.580 rs1523519 chr3:121631841 C/T cg20356878 chr3:121714668 ILDR1 -0.47 -7.49 -0.38 6.34e-13 Multiple sclerosis; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg18789337 chr6:114180353 MARCKS 0.47 6.76 0.35 6.15e-11 Response to antipsychotic treatment; CRC trans rs11165623 0.715 rs1980769 chr1:96888201 A/T cg10631902 chr5:14652156 NA -0.52 -9.86 -0.48 2.91e-20 Hip circumference;Waist circumference; CRC trans rs10983614 1.000 rs7867776 chr9:120072627 A/G cg02092906 chr6:83903419 PGM3;RWDD2A 0.45 6.15 0.32 2.22e-9 Survival in pancreatic cancer; CRC cis rs2249625 0.526 rs17725666 chr6:72889711 G/A cg18830697 chr6:72922368 RIMS1 0.41 8.25 0.41 3.95e-15 Acute urticaria and angioedema (non-steroidal anti-inflammatory drug-induced); CRC cis rs972578 0.806 rs738397 chr22:43295271 C/T cg01576275 chr22:43409880 NA -0.42 -6.58 -0.34 1.91e-10 Mean platelet volume; CRC cis rs12476592 0.571 rs10865341 chr2:63824050 A/T cg10828910 chr2:63850056 LOC388955 0.48 5.86 0.31 1.15e-8 Childhood ear infection; CRC cis rs651907 0.535 rs61396602 chr3:101509046 T/C cg11279151 chr3:101281821 RG9MTD1 -0.53 -7.04 -0.36 1.14e-11 Colorectal cancer; CRC trans rs4942242 1.000 rs9594987 chr13:44230994 C/T cg19169023 chr15:41853346 TYRO3 0.53 7.96 0.4 2.73e-14 Response to tocilizumab in rheumatoid arthritis; CRC trans rs1814175 0.587 rs7937757 chr11:49978342 G/A cg11707556 chr5:10655725 ANKRD33B -0.52 -10.05 -0.48 6.61e-21 Height; CRC cis rs4936891 0.577 rs12225469 chr11:123902719 G/A cg22125253 chr11:123886957 OR10G4 -0.33 -5.79 -0.3 1.63e-8 Male fertility; CRC cis rs6743376 0.556 rs3820738 chr2:113819439 A/G cg09040174 chr2:113837401 NA 0.38 5.75 0.3 2.02e-8 Inflammatory biomarkers; CRC cis rs9733 0.680 rs3738484 chr1:150552330 G/T cg18016565 chr1:150552671 MCL1 -0.46 -7.06 -0.36 1.01e-11 Tonsillectomy; CRC cis rs6960043 0.818 rs2358158 chr7:15054063 T/C cg19272540 chr7:15055459 NA 0.24 6.53 0.34 2.46e-10 Type 2 diabetes; CRC cis rs2180341 1.000 rs6569483 chr6:127658855 G/A cg27446573 chr6:127587934 RNF146 0.98 14.42 0.62 6.85e-37 Breast cancer; CRC cis rs1055129 0.655 rs8067076 chr17:73837142 G/T cg12407791 chr17:73824354 UNC13D 0.28 6.37 0.33 6.3e-10 White matter hyperintensity burden; CRC cis rs6076065 0.748 rs4815198 chr20:23343491 T/C cg11657817 chr20:23433608 CST11 0.54 9.1 0.45 9e-18 Facial morphology (factor 15, philtrum width); CRC cis rs79349575 0.783 rs4793992 chr17:47008207 A/G cg00947319 chr17:47005597 UBE2Z -0.33 -5.64 -0.3 3.69e-8 Type 2 diabetes; CRC cis rs6694672 1.000 rs9427662 chr1:196946775 T/C cg13682187 chr1:196946512 CFHR5 -0.51 -8.08 -0.41 1.21e-14 Asthma; CRC cis rs4638749 0.677 rs6755078 chr2:108818270 T/C cg25838818 chr2:108905173 SULT1C2 -0.33 -5.6 -0.3 4.47e-8 Blood pressure; CRC cis rs6502050 0.835 rs6502068 chr17:80112223 C/T cg25804541 chr17:80189381 SLC16A3 -0.31 -5.98 -0.31 5.77e-9 Life satisfaction; CRC cis rs9649213 0.593 rs7776638 chr7:97993506 C/T cg21770322 chr7:97807741 LMTK2 0.53 8.62 0.43 2.78e-16 Prostate cancer (SNP x SNP interaction); CRC cis rs1983170 0.735 rs963910 chr1:92014136 T/C cg21854759 chr1:92012499 NA -0.47 -6.68 -0.35 9.97e-11 Eosinophil percentage of white cells; CRC cis rs7224737 1.000 rs7224737 chr17:40289364 A/G cg02228675 chr17:40259724 DHX58 0.44 6.07 0.32 3.45e-9 Fibrinogen levels; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg14032529 chr10:114712217 TCF7L2 -0.41 -6.16 -0.32 2.13e-9 Myopia (pathological); CRC cis rs2463822 0.858 rs2513077 chr11:62105925 A/G cg06239285 chr11:62104954 ASRGL1 -0.93 -10.98 -0.52 4.09e-24 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs2153535 0.541 rs6938688 chr6:8521629 G/T cg07606381 chr6:8435919 SLC35B3 0.64 10.48 0.5 2.35e-22 Motion sickness; CRC cis rs4481887 0.927 rs4537599 chr1:248508741 G/A cg00666640 chr1:248458726 OR2T12 0.57 9.81 0.48 4.2e-20 Common traits (Other); CRC cis rs8180040 0.764 rs4683324 chr3:47251284 T/C cg10298567 chr3:47292165 KIF9 -0.38 -6.22 -0.32 1.47e-9 Colorectal cancer; CRC cis rs924607 0.966 rs1709554 chr5:637443 A/G cg04476341 chr5:669733 TPPP 0.42 6.88 0.35 3.1e-11 Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia; CRC cis rs933688 1.000 rs10041402 chr5:90738948 A/T cg02339078 chr5:90679543 LOC100129716;ARRDC3 0.92 14.84 0.63 1.66e-38 Smoking behavior; CRC cis rs2032447 0.714 rs199734 chr6:25940393 G/C cg12588279 chr6:26043732 HIST1H2BB 0.42 5.86 0.31 1.12e-8 Intelligence (multi-trait analysis); CRC cis rs1577917 0.958 rs2084294 chr6:86565943 A/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.5 -6.61 -0.34 1.52e-10 Response to antipsychotic treatment; CRC cis rs10504229 0.683 rs61364624 chr8:58134339 T/A cg24829409 chr8:58192753 C8orf71 -0.55 -8.03 -0.4 1.71e-14 Developmental language disorder (linguistic errors); CRC cis rs4319547 1.000 rs7307735 chr12:123087442 A/G cg23029597 chr12:123009494 RSRC2 -0.62 -8.05 -0.41 1.56e-14 Body mass index; CRC cis rs477895 0.713 rs67546972 chr11:63962162 G/A cg04317338 chr11:64019027 PLCB3 0.6 7.36 0.38 1.45e-12 Mean platelet volume; CRC cis rs1158570 0.564 rs2791343 chr8:131316030 C/T cg26053073 chr8:131455383 NA 0.4 6.21 0.32 1.59e-9 Platelet count; CRC cis rs1559088 0.600 rs58173463 chr19:33596749 C/T cg17764715 chr19:33622953 WDR88 0.46 6.72 0.35 8.25e-11 Bone ultrasound measurement (broadband ultrasound attenuation); CRC cis rs9733 0.715 rs7534124 chr1:150739073 C/T cg18016565 chr1:150552671 MCL1 -0.39 -5.7 -0.3 2.72e-8 Tonsillectomy; CRC cis rs12474201 0.928 rs34186074 chr2:46965010 T/C cg06386533 chr2:46925753 SOCS5 0.83 13.79 0.61 1.88e-34 Height; CRC cis rs7666738 0.830 rs7694889 chr4:98855596 T/C cg17366294 chr4:99064904 C4orf37 0.4 6.48 0.34 3.45e-10 Colonoscopy-negative controls vs population controls; CRC cis rs7493 1.000 rs17876124 chr7:95045258 C/G cg19678392 chr7:94953810 PON1 -0.56 -7.06 -0.36 9.89e-12 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs9311676 0.632 rs11923181 chr3:58380569 A/C cg06643156 chr3:58380774 PXK 0.41 6.33 0.33 7.82e-10 Systemic lupus erythematosus; CRC cis rs2576037 0.526 rs2051292 chr18:44484372 C/G cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.7 -11.25 -0.53 4.5e-25 Personality dimensions; CRC cis rs727505 0.954 rs1009450 chr7:124628723 C/G cg23710748 chr7:124431027 NA -0.78 -13.69 -0.6 4.3e-34 Lewy body disease; CRC cis rs6690583 0.697 rs4907126 chr1:85523453 C/T cg11262906 chr1:85462892 MCOLN2 0.49 7.01 0.36 1.32e-11 Serum sulfate level; CRC cis rs17767392 0.813 rs36052007 chr14:71984705 G/C cg13720639 chr14:72061746 SIPA1L1 -0.49 -6.4 -0.33 5.31e-10 Mitral valve prolapse; CRC cis rs4689592 0.503 rs11937667 chr4:7057037 C/G cg26116260 chr4:7069785 GRPEL1 -0.86 -10.3 -0.49 9.82e-22 Monocyte percentage of white cells; CRC cis rs2806561 0.765 rs2776815 chr1:23510584 C/T cg12483005 chr1:23474871 LUZP1 -0.49 -7.12 -0.37 6.86e-12 Height; CRC cis rs9747201 0.926 rs8065606 chr17:80063526 G/A cg02741985 chr17:80059408 CCDC57 -0.43 -5.78 -0.3 1.74e-8 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs8060686 0.641 rs8044014 chr16:68209872 T/C cg26727032 chr16:67993705 SLC12A4 -0.57 -7.56 -0.38 4.01e-13 HDL cholesterol;Metabolic syndrome; CRC cis rs1552244 0.872 rs6771931 chr3:10113408 C/G cg16606324 chr3:10149918 C3orf24 0.7 9.64 0.47 1.61e-19 Alzheimer's disease; CRC cis rs9916302 0.861 rs752314 chr17:37410700 C/T cg07936489 chr17:37558343 FBXL20 -0.84 -13.32 -0.59 1.12e-32 Glomerular filtration rate (creatinine); CRC cis rs7666738 0.830 rs10014284 chr4:98681951 G/C cg05340658 chr4:99064831 C4orf37 0.56 8.43 0.42 1.12e-15 Colonoscopy-negative controls vs population controls; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg23151374 chr4:164415611 C4orf43 0.44 6.23 0.32 1.44e-9 Response to antipsychotic treatment; CRC cis rs12760731 0.582 rs4433354 chr1:178532484 C/T cg00404053 chr1:178313656 RASAL2 -0.69 -7.64 -0.39 2.42e-13 Obesity-related traits; CRC cis rs6570726 0.935 rs408723 chr6:145838535 A/G cg05347473 chr6:146136440 FBXO30 0.37 6.0 0.31 5.27e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs6604026 0.671 rs6697543 chr1:93312295 C/A cg17283838 chr1:93427260 FAM69A -0.48 -6.86 -0.35 3.37e-11 Multiple sclerosis; CRC trans rs61931739 0.534 rs1384860 chr12:34045388 T/C cg26384229 chr12:38710491 ALG10B 0.51 6.88 0.35 3.1e-11 Morning vs. evening chronotype; CRC cis rs4862750 0.872 rs9998172 chr4:187898773 T/C cg11301795 chr4:187892539 NA -0.87 -19.96 -0.74 1.28e-58 Lobe attachment (rater-scored or self-reported); CRC cis rs4654899 0.802 rs17416732 chr1:21256368 T/C cg02927042 chr1:21476669 EIF4G3 -0.5 -7.8 -0.4 8.23e-14 Superior frontal gyrus grey matter volume; CRC cis rs7586879 1.000 rs7586879 chr2:25116977 C/T cg22495460 chr2:25135724 ADCY3 -0.72 -11.6 -0.54 2.51e-26 Body mass index; CRC cis rs4740619 0.619 rs4741560 chr9:16043170 C/T cg14451791 chr9:16040625 NA 0.23 5.69 0.3 2.86e-8 Body mass index; CRC cis rs116095464 0.614 rs62344292 chr5:244630 G/A cg22496380 chr5:211416 CCDC127 -0.93 -10.56 -0.5 1.18e-22 Breast cancer; CRC cis rs3862030 0.720 rs7341995 chr10:104223831 G/A cg11453585 chr10:104263688 ACTR1A;SUFU -0.81 -13.96 -0.61 4.09e-35 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for body mass index; CRC cis rs2836950 0.585 rs1029004 chr21:40615343 A/G cg11890956 chr21:40555474 PSMG1 -0.65 -9.73 -0.47 7.99e-20 Menarche (age at onset); CRC cis rs10256972 0.616 rs4998392 chr7:1113344 A/C cg23708337 chr7:1209742 NA 0.39 5.9 0.31 8.79e-9 Longevity;Endometriosis; CRC cis rs853679 0.517 rs12174753 chr6:28042465 C/G cg02683197 chr6:28174875 NA 0.79 9.62 0.47 1.8e-19 Depression; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg26145502 chr1:8939074 ENO1 0.37 6.15 0.32 2.26e-9 Liver disease severity in Alagille syndrome; CRC trans rs7613875 0.620 rs2526747 chr3:50082914 C/G cg21659725 chr3:3221576 CRBN 0.44 6.37 0.33 6.55e-10 Body mass index; CRC trans rs9929218 0.551 rs3785134 chr16:68728938 C/T cg04657470 chr2:198365150 HSPE1;HSPD1 1.06 21.85 0.77 5.07e-66 Colorectal cancer; CRC cis rs12900413 0.687 rs7176981 chr15:90315757 A/G cg24249390 chr15:90295951 MESP1 -0.59 -9.58 -0.47 2.51e-19 Coronary artery aneurysm in Kawasaki disease; CRC cis rs898097 0.510 rs10445242 chr17:80891666 G/T cg03160526 chr17:80928410 B3GNTL1 0.49 8.05 0.41 1.52e-14 Breast cancer; CRC cis rs7193541 0.695 rs7199490 chr16:74716026 G/A cg01733217 chr16:74700730 RFWD3 0.85 13.75 0.6 2.63e-34 Multiple myeloma; CRC cis rs3106136 0.967 rs66581998 chr4:95196901 T/C cg11021082 chr4:95130006 SMARCAD1 -0.47 -7.23 -0.37 3.34e-12 Capecitabine sensitivity; CRC cis rs1018836 0.923 rs4735260 chr8:91617157 C/G cg16814680 chr8:91681699 NA 0.74 11.72 0.54 9.84e-27 Ejection fraction in Tripanosoma cruzi seropositivity; CRC cis rs6693567 0.545 rs7553647 chr1:150472666 C/T cg04165759 chr1:150448943 RPRD2 0.36 5.87 0.31 1.05e-8 Migraine; CRC cis rs769267 0.930 rs1865034 chr19:19605763 C/T cg02546618 chr19:19431379 KIAA0892;SF4 0.45 6.13 0.32 2.57e-9 Tonsillectomy; CRC cis rs2213920 0.516 rs13301972 chr9:118158086 C/T cg13918206 chr9:118159781 DEC1 -0.83 -7.54 -0.38 4.63e-13 Docetaxel-induced peripheral neuropathy in metastatic castrate-resistant prostate cancer; CRC cis rs9296092 0.538 rs5000098 chr6:33519231 T/G cg13560919 chr6:33536144 NA -0.45 -6.25 -0.33 1.27e-9 Age at smoking initiation in chronic obstructive pulmonary disease; CRC cis rs13108904 0.901 rs7673398 chr4:1300077 G/A cg24560729 chr4:1342394 KIAA1530 0.34 6.27 0.33 1.1e-9 Obesity-related traits; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg25671651 chr2:203776787 ALS2CR8;WDR12 0.48 6.29 0.33 1.01e-9 Thyroid stimulating hormone; CRC cis rs727505 0.826 rs11532793 chr7:124747952 A/G cg23710748 chr7:124431027 NA -0.72 -11.95 -0.55 1.45e-27 Lewy body disease; CRC cis rs11583043 1.000 rs6682873 chr1:101470906 C/A cg16556008 chr1:101360663 SLC30A7;EXTL2 0.45 5.68 0.3 3.01e-8 Ulcerative colitis;Inflammatory bowel disease; CRC cis rs1799949 0.965 rs4793204 chr17:41279298 A/G cg19454999 chr17:41278357 BRCA1;NBR2 0.55 8.63 0.43 2.68e-16 Menopause (age at onset); CRC cis rs2739330 0.828 rs4820572 chr22:24250355 T/C cg24846343 chr22:24311635 DDTL 0.81 13.55 0.6 1.51e-33 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs9816226 1.000 rs61587156 chr3:185831583 T/G cg00760338 chr3:185826511 ETV5 -0.77 -7.8 -0.4 8.22e-14 Obesity;Body mass index; CRC cis rs6684514 1.000 rs2277871 chr1:156246742 A/G cg16558208 chr1:156270281 VHLL 0.58 9.08 0.45 1.03e-17 Mean corpuscular hemoglobin concentration;Glycated hemoglobin levels; CRC trans rs5417 0.662 rs8067500 chr17:7172631 A/G cg15655154 chr3:113604241 GRAMD1C 0.56 8.62 0.43 2.78e-16 Diastolic blood pressure; CRC cis rs2985684 0.948 rs12897941 chr14:50016701 G/C cg04989706 chr14:50066350 PPIL5 -0.58 -8.13 -0.41 8.78e-15 Carotid intima media thickness; CRC cis rs67311347 1.000 rs56291770 chr3:40515370 T/C cg24209194 chr3:40518798 ZNF619 0.41 5.72 0.3 2.33e-8 Renal cell carcinoma; CRC cis rs7949030 0.523 rs12223627 chr11:62368557 G/C cg11742103 chr11:62369870 EML3;MTA2 0.57 9.54 0.47 3.41e-19 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; CRC cis rs9329289 0.926 rs9329290 chr10:2542751 G/T cg15501526 chr10:2543763 NA 0.76 16.13 0.66 1.56e-43 Age-related hearing impairment; CRC cis rs3020333 1.000 rs3020333 chr6:152010254 A/G cg22157087 chr6:152012887 ESR1 0.51 7.55 0.38 4.21e-13 Total body bone mineral density; CRC cis rs2836974 0.799 rs13047550 chr21:40515495 T/C cg17971929 chr21:40555470 PSMG1 0.72 9.71 0.47 9.39e-20 Cognitive function; CRC cis rs6952808 0.723 rs11765550 chr7:2027324 G/A cg20295408 chr7:1910781 MAD1L1 -0.41 -5.62 -0.3 4.17e-8 Bipolar disorder and schizophrenia; CRC cis rs7043114 0.525 rs7853859 chr9:95151377 A/G cg14631576 chr9:95140430 CENPP -0.31 -5.98 -0.31 5.9e-9 Height; CRC cis rs2070997 0.756 rs3824400 chr9:133734075 A/G cg01000188 chr9:133769184 QRFP -0.52 -6.13 -0.32 2.53e-9 Response to amphetamines; CRC cis rs7172677 0.501 rs8040061 chr15:75393720 C/A cg14664628 chr15:75095509 CSK 0.44 6.18 0.32 1.9e-9 Systemic lupus erythematosus and Systemic sclerosis; CRC trans rs2832077 0.527 rs9980449 chr21:30224889 G/C cg14791747 chr16:20752902 THUMPD1 0.67 10.83 0.51 1.46e-23 Cognitive test performance; CRC cis rs6502050 0.740 rs4789748 chr17:80093061 A/C cg02741985 chr17:80059408 CCDC57 0.43 7.15 0.37 5.49e-12 Life satisfaction; CRC cis rs2075371 0.933 rs2544191 chr7:133954248 A/G cg11752832 chr7:134001865 SLC35B4 0.44 6.72 0.35 8.13e-11 Mean platelet volume; CRC cis rs1218582 0.774 rs2335409 chr1:154916106 G/A cg06221963 chr1:154839813 KCNN3 -0.77 -14.52 -0.62 3.04e-37 Prostate cancer; CRC cis rs873946 0.648 rs12767126 chr10:134556992 C/T cg26818010 chr10:134567672 INPP5A -0.68 -8.5 -0.42 6.71e-16 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CRC trans rs9858542 0.953 rs9821311 chr3:49543656 C/T cg21665057 chr3:196295764 WDR53;FBXO45 -0.66 -9.1 -0.45 8.6e-18 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs12422267 0.536 rs7976530 chr12:132609140 C/T cg09764611 chr12:132620959 NA -0.62 -8.62 -0.43 2.77e-16 Plasma amyloid beta peptide concentrations (ABx-40); CRC cis rs11971779 0.680 rs6949599 chr7:139054188 A/G cg07862535 chr7:139043722 LUC7L2 0.57 7.35 0.38 1.61e-12 Diisocyanate-induced asthma; CRC cis rs10178094 0.528 rs62175963 chr2:161339964 T/C cg03641300 chr2:160917029 PLA2R1 -0.45 -6.11 -0.32 2.77e-9 White blood cell count; CRC cis rs853679 0.517 rs9380058 chr6:28127444 T/C cg23161317 chr6:28129485 ZNF389 0.54 6.47 0.34 3.49e-10 Depression; CRC cis rs9814567 0.929 rs1863911 chr3:134205231 C/A cg06541857 chr3:134203789 ANAPC13;CEP63 -0.42 -6.43 -0.33 4.42e-10 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs55794721 0.509 rs12027110 chr1:25775682 A/T cg02931644 chr1:25747376 RHCE 0.32 5.68 0.3 2.94e-8 Plateletcrit;Mean corpuscular volume; CRC cis rs4638749 0.677 rs12329189 chr2:108812855 T/C cg25838818 chr2:108905173 SULT1C2 -0.34 -5.71 -0.3 2.53e-8 Blood pressure; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg27054308 chr14:20922865 APEX1;OSGEP 0.49 7.17 0.37 4.91e-12 Response to antipsychotic treatment; CRC cis rs11148252 0.538 rs2408609 chr13:52714043 C/T cg00495681 chr13:53174319 NA 0.62 9.28 0.46 2.26e-18 Lewy body disease; CRC cis rs10504229 0.679 rs12375285 chr8:58040084 G/A cg22535103 chr8:58192502 C8orf71 -0.52 -6.32 -0.33 8.67e-10 Developmental language disorder (linguistic errors); CRC cis rs10782582 0.545 rs111927462 chr1:76195422 A/G cg10523679 chr1:76189770 ACADM -0.44 -6.17 -0.32 2.03e-9 Daytime sleep phenotypes; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg15312298 chr8:127570908 FAM84B 0.41 6.15 0.32 2.28e-9 Intelligence (multi-trait analysis); CRC cis rs7493 1.000 rs6968305 chr7:95042529 G/A cg07404485 chr7:94953653 PON1 -0.45 -5.93 -0.31 7.79e-9 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs514406 0.929 rs12410420 chr1:53323754 T/C cg24675658 chr1:53192096 ZYG11B -0.57 -8.48 -0.42 7.77e-16 Monocyte count; CRC cis rs3733346 0.529 rs6842493 chr4:914638 T/C cg15105011 chr4:940614 TMEM175 0.55 9.11 0.45 8.44e-18 Sjögren's syndrome; CRC cis rs2062225 1.000 rs1157455 chr2:111760081 G/A cg11729679 chr2:111877065 BCL2L11 -0.56 -5.64 -0.3 3.67e-8 Monocyte count; CRC cis rs62064224 0.589 rs9904964 chr17:30662832 A/G cg21839984 chr17:30846986 MYO1D 0.34 5.7 0.3 2.6e-8 Schizophrenia; CRC cis rs2000999 0.691 rs11648003 chr16:72052348 A/G cg01557791 chr16:72042693 DHODH -0.55 -5.9 -0.31 8.98e-9 Total cholesterol levels;Cholesterol, total;Blood protein levels;LDL cholesterol levels;Haptoglobin levels;LDL cholesterol; CRC cis rs7618915 0.571 rs11130307 chr3:52607682 G/A cg05573699 chr3:52720067 GNL3;PBRM1 -0.44 -6.27 -0.33 1.14e-9 Bipolar disorder; CRC cis rs6445525 1.000 rs4416407 chr3:65995747 T/C cg06109867 chr3:66002991 MAGI1 -0.39 -6.41 -0.33 5e-10 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs9381040 0.655 rs9381029 chr6:41026453 G/C cg04346459 chr6:41068666 NFYA;LOC221442 -0.41 -6.15 -0.32 2.19e-9 Alzheimer's disease (late onset); CRC cis rs11690935 0.921 rs10200608 chr2:172597929 G/A cg13550731 chr2:172543902 DYNC1I2 -1.09 -18.38 -0.71 2.03e-52 Schizophrenia; CRC trans rs2727020 0.729 rs1917325 chr11:49370004 G/A cg11707556 chr5:10655725 ANKRD33B -0.36 -6.63 -0.34 1.36e-10 Coronary artery disease; CRC cis rs853679 0.546 rs200490 chr6:27796935 G/T cg03623178 chr6:28175578 NA 0.79 6.96 0.36 1.89e-11 Depression; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg18318636 chr17:56591750 MTMR4 0.46 6.75 0.35 6.68e-11 Response to antipsychotic treatment; CRC cis rs35740288 0.520 rs56183577 chr15:86319706 A/G cg20737812 chr15:86336631 KLHL25 -0.49 -7.34 -0.38 1.66e-12 Eosinophil percentage of white cells;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes; CRC cis rs7481584 0.581 rs406598 chr11:3076285 G/A cg25174290 chr11:3078921 CARS -0.43 -5.94 -0.31 7.07e-9 Calcium levels; CRC cis rs1511802 0.666 rs4862662 chr4:187118662 A/C cg24794857 chr4:187113578 CYP4V2 -0.39 -5.79 -0.3 1.62e-8 Blood protein levels; CRC cis rs8141797 0.901 rs76376425 chr22:24523177 C/T cg20894457 chr22:24584366 SUSD2 0.65 6.83 0.35 4.08e-11 Amyotrophic lateral sclerosis;Coronary artery disease; CRC cis rs1448094 0.512 rs1349063 chr12:86264237 C/T cg18827107 chr12:86230957 RASSF9 -0.45 -7.32 -0.37 1.96e-12 Major depressive disorder; CRC cis rs554111 0.891 rs659046 chr1:21047725 C/T cg08890418 chr1:21044141 KIF17 -0.33 -6.17 -0.32 2.04e-9 Facial morphology (factor 17, height of vermillion upper lip); CRC cis rs6460942 0.730 rs73053536 chr7:12323131 C/G cg06484146 chr7:12443880 VWDE -0.75 -6.47 -0.34 3.48e-10 Coronary artery disease; CRC cis rs1448094 0.511 rs4469976 chr12:86146723 T/C cg00310523 chr12:86230176 RASSF9 -0.36 -5.92 -0.31 8.25e-9 Major depressive disorder; CRC trans rs10983614 1.000 rs7867776 chr9:120072627 A/G cg20782850 chr6:117002205 KPNA5 0.44 5.96 0.31 6.48e-9 Survival in pancreatic cancer; CRC cis rs6429082 0.818 rs704706 chr1:235614378 G/A cg26050004 chr1:235667680 B3GALNT2 0.55 7.34 0.38 1.67e-12 Adiposity; CRC cis rs6089584 0.606 rs2144674 chr20:60576579 G/A cg23262073 chr20:60523788 NA -0.4 -6.88 -0.35 2.98e-11 Body mass index; CRC trans rs3774749 0.565 rs2518795 chr3:50208819 C/T cg21659725 chr3:3221576 CRBN 0.44 6.47 0.34 3.45e-10 Intelligence (multi-trait analysis); CRC cis rs9322817 0.691 rs6907016 chr6:105211360 G/A cg02098413 chr6:105308735 HACE1 -0.44 -8.51 -0.42 6.37e-16 Thyroid stimulating hormone; CRC trans rs11098499 0.913 rs67073020 chr4:120152557 C/T cg25214090 chr10:38739885 LOC399744 0.54 8.09 0.41 1.14e-14 Corneal astigmatism; CRC cis rs2859741 0.565 rs12023397 chr1:37507739 G/A cg09363841 chr1:37513479 NA -0.48 -7.46 -0.38 7.6e-13 Forced expiratory volume in 1 second (environmental tobacco smoke interaction); CRC cis rs17270561 0.639 rs9356989 chr6:25781950 A/G cg16482183 chr6:26056742 HIST1H1C 0.82 9.94 0.48 1.53e-20 Iron status biomarkers; CRC cis rs34779708 0.931 rs35886556 chr10:35334985 C/T cg03585969 chr10:35415529 CREM 0.65 8.64 0.43 2.46e-16 Inflammatory bowel disease;Crohn's disease; CRC cis rs10504229 1.000 rs17805656 chr8:58180318 T/C cg02290350 chr8:58132656 NA -0.42 -5.96 -0.31 6.62e-9 Developmental language disorder (linguistic errors); CRC cis rs1832871 0.643 rs112195967 chr6:158775695 C/T cg07165851 chr6:158734300 TULP4 0.61 7.76 0.39 1.11e-13 Height; CRC cis rs9925964 0.967 rs889548 chr16:31137712 A/G cg10396673 chr16:31104726 VKORC1 -0.34 -5.61 -0.3 4.24e-8 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs7264396 0.561 rs2064725 chr20:34569142 G/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.59 -7.84 -0.4 6.24e-14 Total cholesterol levels; CRC cis rs25422 0.938 rs9489443 chr6:118886163 T/A cg22561889 chr6:118971681 C6orf204 0.51 6.58 0.34 1.84e-10 Renal cell carcinoma; CRC cis rs12135062 0.851 rs2651925 chr1:3101863 C/G cg25382214 chr1:3105252 PRDM16 0.42 6.85 0.35 3.74e-11 Migraine; CRC cis rs6089584 0.888 rs6061405 chr20:60617033 A/G cg06108461 chr20:60628389 TAF4 -0.86 -14.45 -0.62 5.68e-37 Body mass index; CRC cis rs9308731 0.644 rs3789061 chr2:111918230 T/C cg04202892 chr2:111875749 ACOXL 0.48 7.88 0.4 4.69e-14 Chronic lymphocytic leukemia; CRC cis rs1707322 0.721 rs6665808 chr1:46162283 C/T cg03146154 chr1:46216737 IPP 0.63 9.22 0.45 3.58e-18 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs2985684 0.894 rs4581611 chr14:50043520 A/T cg23565292 chr14:50234668 KLHDC2 -0.43 -6.16 -0.32 2.14e-9 Carotid intima media thickness; CRC trans rs12599106 0.754 rs11640596 chr16:34347277 T/C cg07332563 chr6:291687 DUSP22 -0.49 -6.99 -0.36 1.57e-11 Menopause (age at onset); CRC trans rs9747201 1.000 rs3922470 chr17:80110159 C/T cg07393940 chr7:158741817 NA -0.52 -7.43 -0.38 9.26e-13 Peripheral arterial disease (traffic-related air pollution interaction); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg24677674 chr10:113943468 GPAM 0.45 6.24 0.33 1.31e-9 Response to antipsychotic treatment; CRC cis rs6502050 0.835 rs9911379 chr17:80114529 A/G cg09264619 chr17:80180166 NA -0.34 -5.79 -0.3 1.65e-8 Life satisfaction; CRC cis rs344364 0.602 rs7188401 chr16:1876949 G/C cg14074117 chr16:1909714 C16orf73 0.35 6.02 0.32 4.53e-9 Glomerular filtration rate in chronic kidney disease; CRC cis rs7618915 0.547 rs10780035 chr3:52764624 C/T cg15147215 chr3:52552868 STAB1 -0.61 -10.04 -0.48 7.46e-21 Bipolar disorder; CRC cis rs10504229 1.000 rs72650892 chr8:58179714 A/G cg02725872 chr8:58115012 NA -0.38 -6.43 -0.33 4.44e-10 Developmental language disorder (linguistic errors); CRC cis rs1707322 1.000 rs10890376 chr1:46406582 C/T cg03146154 chr1:46216737 IPP 0.58 8.18 0.41 6.07e-15 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs597539 0.652 rs507520 chr11:68666054 C/T cg06112835 chr11:68658793 MRPL21 0.48 7.64 0.39 2.37e-13 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs11190604 0.767 rs10883489 chr10:102194532 T/C cg07080220 chr10:102295463 HIF1AN 0.5 6.32 0.33 8.69e-10 Palmitoleic acid (16:1n-7) levels; CRC cis rs8060686 0.623 rs255049 chr16:68013471 T/C cg26727032 chr16:67993705 SLC12A4 -0.68 -10.45 -0.5 2.85e-22 HDL cholesterol;Metabolic syndrome; CRC cis rs10174077 0.687 rs10172023 chr2:152476028 C/G cg19508488 chr2:152266495 RIF1 0.49 6.2 0.32 1.68e-9 Squamous cell lung carcinoma; CRC cis rs7044106 0.664 rs7861679 chr9:123375589 A/G cg09586646 chr9:123605570 PSMD5;LOC253039 -0.55 -8.22 -0.41 4.78e-15 Hip circumference adjusted for BMI; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg24218995 chr18:67873134 RTTN 0.41 6.07 0.32 3.52e-9 Response to antipsychotic treatment; CRC cis rs4665809 0.590 rs1049987 chr2:26413817 C/T cg25036284 chr2:26402008 FAM59B 0.62 7.76 0.39 1.12e-13 Gut microbiome composition (summer); CRC cis rs57590327 0.503 rs11706976 chr3:81899653 C/T cg07356753 chr3:81810745 GBE1 -0.63 -8.54 -0.43 4.95e-16 Extraversion; CRC trans rs2303319 0.582 rs12464282 chr2:162448855 C/T cg18122310 chr12:50236657 BCDIN3D -0.72 -6.17 -0.32 2.06e-9 Cognitive function; CRC cis rs78456975 1.000 rs13414537 chr2:1556330 C/T cg26248373 chr2:1572462 NA -0.67 -7.14 -0.37 6.12e-12 Placebo response in major depressive disorder (% change in symptom score); CRC cis rs1153858 1.000 rs66714503 chr15:45648038 G/C cg10760299 chr15:45669010 GATM 0.49 7.79 0.39 8.71e-14 Homoarginine levels; CRC cis rs1336900 0.637 rs35967040 chr1:150555588 A/C cg15448220 chr1:150897856 SETDB1 -0.44 -6.29 -0.33 1.04e-9 Blood protein levels; CRC cis rs9486719 0.741 rs976356 chr6:96849437 T/A cg06623918 chr6:96969491 KIAA0776 0.79 8.48 0.42 7.89e-16 Migraine;Coronary artery disease; CRC cis rs10504229 0.775 rs56082079 chr8:58163732 T/C cg02290350 chr8:58132656 NA -0.5 -6.18 -0.32 1.95e-9 Developmental language disorder (linguistic errors); CRC cis rs11577318 0.579 rs11247936 chr1:26698884 A/G cg00852783 chr1:26633632 UBXN11 -0.45 -5.89 -0.31 9.65e-9 Granulocyte percentage of myeloid white cells; CRC cis rs12760731 0.920 rs9658883 chr1:178480315 A/G cg00404053 chr1:178313656 RASAL2 0.57 6.85 0.35 3.65e-11 Obesity-related traits; CRC cis rs1862618 0.853 rs33325 chr5:56142547 G/C cg20203395 chr5:56204925 C5orf35 -0.69 -8.26 -0.41 3.72e-15 Initial pursuit acceleration; CRC cis rs60871478 0.730 rs62432226 chr7:792973 T/C cg05535760 chr7:792225 HEATR2 0.99 12.45 0.57 1.96e-29 Cerebrospinal P-tau181p levels; CRC trans rs9329221 0.868 rs7831557 chr8:10280228 C/T cg16141378 chr3:129829833 LOC729375 0.49 7.48 0.38 6.65e-13 Neuroticism; CRC cis rs6089584 0.888 rs6061979 chr20:60617141 C/G cg13770153 chr20:60521292 NA -0.58 -8.79 -0.44 8.58e-17 Body mass index; CRC cis rs10504229 0.775 rs55734109 chr8:58162322 G/A cg21724239 chr8:58056113 NA 0.63 7.89 0.4 4.52e-14 Developmental language disorder (linguistic errors); CRC cis rs11122272 0.735 rs2486737 chr1:231520523 T/C cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.54 -8.09 -0.41 1.18e-14 Hemoglobin concentration; CRC trans rs1005277 0.579 rs1985707 chr10:38434098 C/T cg17830980 chr10:43048298 ZNF37B -0.59 -9.89 -0.48 2.23e-20 Extrinsic epigenetic age acceleration; CRC cis rs727505 1.000 rs7790856 chr7:124459852 C/T cg23710748 chr7:124431027 NA -0.68 -12.18 -0.56 1.93e-28 Lewy body disease; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg26301297 chr10:123734889 NSMCE4A 0.51 7.52 0.38 5.35e-13 Response to antipsychotic treatment; CRC trans rs2228479 0.867 rs2270459 chr16:89979851 A/C cg24644049 chr4:85504048 CDS1 -0.68 -7.04 -0.36 1.16e-11 Skin colour saturation; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg10243787 chr22:19419481 HIRA;MRPL40 0.45 6.47 0.34 3.63e-10 Intelligence (multi-trait analysis); CRC cis rs10504229 0.593 rs17192845 chr8:58053339 C/T cg08219700 chr8:58056026 NA 0.58 6.69 0.35 9.52e-11 Developmental language disorder (linguistic errors); CRC cis rs853679 0.517 rs9393895 chr6:28127621 T/C cg12273811 chr6:28175739 NA 0.7 8.79 0.44 8.29e-17 Depression; CRC cis rs3749237 0.595 rs1464566 chr3:49459376 T/C cg03060546 chr3:49711283 APEH 0.61 10.33 0.49 7.69e-22 Resting heart rate; CRC cis rs4604732 0.631 rs7546720 chr1:247627229 G/A cg02104434 chr1:247694406 LOC148824;OR2C3 0.6 8.82 0.44 6.67e-17 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CRC cis rs72772090 0.539 rs11742261 chr5:96167608 C/T cg17330273 chr5:96107758 CAST;ERAP1 -0.6 -5.88 -0.31 1.01e-8 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs10991814 0.844 rs58307373 chr9:94070782 T/C cg14446406 chr9:93919335 NA 0.5 5.94 0.31 7.43e-9 Neutrophil percentage of granulocytes; CRC cis rs9322193 0.962 rs11155685 chr6:150102785 A/C cg00933542 chr6:150070202 PCMT1 0.28 5.63 0.3 3.86e-8 Lung cancer; CRC cis rs8060686 0.545 rs12600062 chr16:68287544 C/A cg26727032 chr16:67993705 SLC12A4 -0.63 -6.45 -0.34 3.95e-10 HDL cholesterol;Metabolic syndrome; CRC cis rs950169 0.881 rs34591918 chr15:84950833 C/T cg11189052 chr15:85197271 WDR73 0.63 8.8 0.44 7.65e-17 Schizophrenia; CRC cis rs853679 0.550 rs9295762 chr6:28155418 C/T cg23161317 chr6:28129485 ZNF389 -0.46 -6.03 -0.32 4.44e-9 Depression; CRC cis rs35146811 0.735 rs858505 chr7:99819577 G/A cg00553149 chr7:99775558 STAG3;GPC2 -0.25 -5.72 -0.3 2.38e-8 Coronary artery disease; CRC cis rs3806843 0.966 rs3756341 chr5:140171194 C/T cg16607685 chr5:140181889 PCDHA2;PCDHA1;PCDHA3 -0.25 -5.84 -0.31 1.25e-8 Depressive symptoms (multi-trait analysis); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg07833644 chr2:27440142 CAD 0.46 6.64 0.34 1.3e-10 Response to antipsychotic treatment; CRC cis rs10504229 0.906 rs113823909 chr8:58170635 A/G cg24829409 chr8:58192753 C8orf71 -0.68 -11.23 -0.53 5.45e-25 Developmental language disorder (linguistic errors); CRC trans rs208515 0.525 rs12204452 chr6:66680325 C/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.94 11.9 0.55 2.04e-27 Exhaled nitric oxide levels; CRC cis rs16936870 0.571 rs7003804 chr8:71089631 T/C cg14232793 chr8:71155543 NCOA2 -0.47 -5.64 -0.3 3.76e-8 QT interval; CRC cis rs11190604 1.000 rs11190552 chr10:102206607 G/A cg16342193 chr10:102329863 NA -0.37 -6.17 -0.32 2.02e-9 Palmitoleic acid (16:1n-7) levels; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg25533220 chr19:2328480 SPPL2B;LSM7 0.48 6.18 0.32 1.94e-9 Thyroid stimulating hormone; CRC cis rs1448094 0.511 rs6539921 chr12:86164163 G/A cg19622623 chr12:86230825 RASSF9 -0.37 -5.73 -0.3 2.33e-8 Major depressive disorder; CRC cis rs11583043 0.874 rs11578366 chr1:101396852 T/A cg00063077 chr1:101360652 SLC30A7;EXTL2 0.5 6.75 0.35 6.87e-11 Ulcerative colitis;Inflammatory bowel disease; CRC cis rs9611565 0.512 rs715498 chr22:42148467 G/A cg03806693 chr22:41940476 POLR3H 1.09 13.49 0.6 2.65e-33 Vitiligo; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg07394347 chr3:37285773 GOLGA4 0.45 6.68 0.35 9.92e-11 Intelligence (multi-trait analysis); CRC cis rs12188164 0.762 rs11745923 chr5:475408 T/G cg26850624 chr5:429559 AHRR -0.77 -12.55 -0.57 8.53e-30 Cystic fibrosis severity; CRC cis rs7811142 0.830 rs11761253 chr7:99939321 C/T cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.67 8.8 0.44 7.66e-17 Platelet count; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg00242285 chr3:124480225 NA 0.45 6.62 0.34 1.43e-10 Response to antipsychotic treatment; CRC cis rs514406 0.689 rs7548389 chr1:53404211 C/T cg24675658 chr1:53192096 ZYG11B -0.63 -9.42 -0.46 8.15e-19 Monocyte count; CRC cis rs7666738 0.830 rs7679961 chr4:99000202 C/T cg05340658 chr4:99064831 C4orf37 0.61 9.54 0.47 3.44e-19 Colonoscopy-negative controls vs population controls; CRC cis rs4481887 0.861 rs1339989 chr1:248511624 C/G cg00666640 chr1:248458726 OR2T12 0.48 8.9 0.44 3.69e-17 Common traits (Other); CRC cis rs11719291 0.833 rs13074318 chr3:48816725 C/T cg00383909 chr3:49044727 WDR6 1.36 12.67 0.57 3e-30 Cognitive function; CRC cis rs4919694 1.000 rs17881215 chr10:104629236 G/C cg04362960 chr10:104952993 NT5C2 0.89 8.7 0.43 1.67e-16 Arsenic metabolism; CRC cis rs28386778 0.897 rs2584639 chr17:61863732 C/T cg07362569 chr17:61921086 SMARCD2 0.39 5.96 0.31 6.34e-9 Prudent dietary pattern; CRC cis rs6831352 0.918 rs13133633 chr4:100058697 C/G cg13256891 chr4:100009986 ADH5 -0.66 -8.89 -0.44 4.04e-17 Alcohol dependence; CRC cis rs950169 0.649 rs12911612 chr15:84691014 T/C cg11189052 chr15:85197271 WDR73 0.58 7.58 0.39 3.65e-13 Schizophrenia; CRC cis rs11583043 0.546 rs35363849 chr1:101591293 A/G cg16556008 chr1:101360663 SLC30A7;EXTL2 0.45 5.79 0.3 1.68e-8 Ulcerative colitis;Inflammatory bowel disease; CRC cis rs282587 0.569 rs390657 chr13:113415085 A/G cg04656015 chr13:113407548 ATP11A 0.59 7.56 0.38 3.96e-13 Glycated hemoglobin levels; CRC cis rs3857067 0.934 rs2865336 chr4:95029357 G/A cg11021082 chr4:95130006 SMARCAD1 -0.38 -5.66 -0.3 3.27e-8 QT interval; CRC cis rs55794721 0.509 rs7554255 chr1:25778106 C/T cg27572855 chr1:25598939 RHD 0.37 6.58 0.34 1.86e-10 Plateletcrit;Mean corpuscular volume; CRC cis rs9649465 0.806 rs6971297 chr7:123293342 A/T cg03229431 chr7:123269106 ASB15 -0.38 -5.77 -0.3 1.86e-8 Migraine; CRC cis rs7191439 0.589 rs11076699 chr16:88756812 A/C cg27087555 chr16:88793112 FAM38A 0.95 7.08 0.36 8.73e-12 Plateletcrit; CRC cis rs4862750 0.914 rs6837117 chr4:187872379 C/T cg06074448 chr4:187884817 NA -0.59 -10.72 -0.51 3.34e-23 Lobe attachment (rater-scored or self-reported); CRC cis rs739401 0.611 rs391188 chr11:3047634 G/A cg05729581 chr11:3078854 CARS -0.56 -8.18 -0.41 6.15e-15 Longevity; CRC cis rs12681288 0.792 rs12678495 chr8:1000858 C/G cg08648136 chr8:956695 NA 0.3 6.03 0.32 4.3e-9 Schizophrenia; CRC cis rs25422 0.887 rs9481844 chr6:118990941 G/A cg10217327 chr6:118973057 C6orf204 0.46 5.66 0.3 3.34e-8 Renal cell carcinoma; CRC cis rs6430585 0.793 rs11684545 chr2:136539122 G/T cg15123519 chr2:136567270 LCT 0.3 5.74 0.3 2.12e-8 Corneal structure; CRC cis rs9487051 0.676 rs9398196 chr6:109601554 A/G cg01475377 chr6:109611718 NA -0.38 -6.53 -0.34 2.44e-10 Reticulocyte fraction of red cells; CRC cis rs4148883 0.645 rs1154404 chr4:100009004 A/T cg12011299 chr4:100065546 ADH4 0.53 11.5 0.54 5.83e-26 Alcohol dependence; CRC cis rs2073300 0.609 rs2281428 chr20:23400050 C/T cg12062639 chr20:23401060 NAPB 0.84 7.63 0.39 2.54e-13 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs3820068 0.581 rs72645864 chr1:15921153 C/T cg27534772 chr1:16042836 PLEKHM2 0.53 10.04 0.48 7.27e-21 Systolic blood pressure; CRC cis rs17376456 0.542 rs2084916 chr5:93194961 A/T cg25358565 chr5:93447407 FAM172A -0.65 -7.6 -0.39 3.09e-13 Diabetic retinopathy; CRC cis rs561341 1.000 rs576985 chr17:30323323 C/T cg00745463 chr17:30367425 LRRC37B -0.88 -9.71 -0.47 9.33e-20 Hip circumference adjusted for BMI; CRC cis rs2549003 1.000 rs2070728 chr5:131819977 C/T cg00255919 chr5:131827918 IRF1 0.59 11.92 0.55 1.77e-27 Asthma (sex interaction); CRC cis rs11098499 0.535 rs7671759 chr4:120248094 A/C cg24375607 chr4:120327624 NA 0.49 7.83 0.4 6.9e-14 Corneal astigmatism; CRC cis rs748404 0.631 rs7167882 chr15:43678663 A/C cg02155558 chr15:43621948 ADAL;LCMT2 0.52 7.4 0.38 1.15e-12 Lung cancer; CRC cis rs11122272 0.735 rs2749699 chr1:231520279 A/C cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.54 -8.09 -0.41 1.18e-14 Hemoglobin concentration; CRC cis rs7647973 0.667 rs6446286 chr3:49681704 A/G cg13072238 chr3:49761600 GMPPB -0.52 -5.92 -0.31 8.06e-9 Menarche (age at onset); CRC trans rs2303319 0.504 rs1449641 chr2:162619567 T/C cg11326919 chr17:43324904 LOC100133991 -0.64 -5.99 -0.31 5.65e-9 Cognitive function; CRC cis rs17767392 0.881 rs7152674 chr14:72016613 G/T cg13720639 chr14:72061746 SIPA1L1 0.51 6.64 0.34 1.3100000000000001e-10 Mitral valve prolapse; CRC cis rs2455601 0.608 rs10840137 chr11:8890079 G/A cg21881798 chr11:8931708 C11orf17;ST5 -0.51 -6.73 -0.35 7.37e-11 Schizophrenia; CRC cis rs9660180 0.836 rs72634845 chr1:1704899 G/A cg03396347 chr1:1875803 NA -0.59 -9.09 -0.45 9.28e-18 Body mass index; CRC cis rs728616 0.764 rs75385771 chr10:81692779 T/C cg05935833 chr10:81318306 SFTPA2 -0.72 -8.19 -0.41 5.66e-15 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs7937682 0.855 rs10891285 chr11:111527775 T/C cg09085632 chr11:111637200 PPP2R1B -1.02 -20.96 -0.76 1.47e-62 Primary sclerosing cholangitis; CRC cis rs7809950 0.953 rs2520267 chr7:107187497 T/C cg23024343 chr7:107201750 COG5 -0.61 -8.69 -0.43 1.72e-16 Coronary artery disease; CRC cis rs11098499 0.863 rs3775848 chr4:120447724 C/T cg24375607 chr4:120327624 NA 0.46 6.98 0.36 1.64e-11 Corneal astigmatism; CRC cis rs847577 0.715 rs4729402 chr7:97707731 A/G cg21770322 chr7:97807741 LMTK2 0.68 12.1 0.55 3.94e-28 Breast cancer; CRC cis rs6866344 0.570 rs56236920 chr5:178144617 C/T cg10224037 chr5:178157518 ZNF354A 0.78 11.44 0.53 9.89e-26 Neutrophil percentage of white cells; CRC cis rs11098499 0.754 rs7672594 chr4:120248543 A/C cg24375607 chr4:120327624 NA 0.48 7.61 0.39 2.87e-13 Corneal astigmatism; CRC cis rs13191362 1.000 rs67094146 chr6:163145412 G/C cg14584255 chr6:163149320 PACRG;PARK2 0.38 6.1 0.32 2.91e-9 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs10504229 0.683 rs11785260 chr8:58132906 A/G cg21724239 chr8:58056113 NA 0.49 6.81 0.35 4.75e-11 Developmental language disorder (linguistic errors); CRC cis rs7843479 0.601 rs11785043 chr8:21810377 C/T cg16476235 chr8:21771668 DOK2 0.37 6.25 0.33 1.29e-9 Mean corpuscular volume; CRC trans rs10789207 0.531 rs20354 chr1:67071356 G/T cg12612336 chr17:74350433 PRPSAP1 0.59 5.96 0.31 6.5e-9 Resting heart rate; CRC cis rs8177253 0.665 rs11921527 chr3:133441167 G/A cg01448562 chr3:133502909 NA -0.37 -5.94 -0.31 7.1e-9 Iron status biomarkers; CRC cis rs7552404 0.924 rs2153126 chr1:76199345 C/G cg03433033 chr1:76189801 ACADM 0.91 14.15 0.62 7.73e-36 Blood metabolite levels;Acylcarnitine levels; CRC cis rs4423214 0.840 rs1792235 chr11:71181473 C/T cg13043300 chr11:71146211 DHCR7 -0.43 -5.82 -0.31 1.36e-8 Vitamin D levels; CRC cis rs12497850 0.931 rs7621015 chr3:49016056 A/G cg20833759 chr3:49053208 WDR6;DALRD3 0.54 9.42 0.46 8.44e-19 Parkinson's disease; CRC cis rs1150668 0.745 rs213238 chr6:28321993 T/C cg15845792 chr6:28175446 NA 0.54 7.78 0.39 9.25e-14 Pubertal anthropometrics; CRC cis rs12188164 0.515 rs11745246 chr5:410943 A/G cg21972741 chr5:435613 AHRR 0.46 6.1 0.32 3.01e-9 Cystic fibrosis severity; CRC cis rs3796352 1.000 rs13072457 chr3:53102389 G/A cg07884673 chr3:53033167 SFMBT1 0.76 6.13 0.32 2.45e-9 Immune reponse to smallpox (secreted IL-2); CRC cis rs9322193 0.886 rs4870055 chr6:150169569 C/T cg07701084 chr6:150067640 NUP43 0.47 6.7 0.35 8.89e-11 Lung cancer; CRC cis rs1691799 0.899 rs4762091 chr12:66747863 A/G cg16791601 chr12:66731901 HELB -0.72 -12.91 -0.58 3.97e-31 White blood cell count (basophil); CRC cis rs10971721 0.749 rs72725375 chr9:33840704 A/G cg13495928 chr9:33750294 PRSS3 0.55 5.9 0.31 9.17e-9 Body mass index; CRC trans rs9956878 0.555 rs8085188 chr18:73544676 A/G cg09300324 chr12:132568690 EP400NL -0.37 -6.12 -0.32 2.72e-9 Obesity-related traits; CRC trans rs11039798 1.000 rs12223271 chr11:48417420 G/C cg03929089 chr4:120376271 NA 0.63 6.15 0.32 2.29e-9 Axial length; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg08263226 chr1:23881409 NA 0.39 6.22 0.32 1.54e-9 Liver disease severity in Alagille syndrome; CRC cis rs10504229 0.728 rs72650856 chr8:58152695 C/T cg05313129 chr8:58192883 C8orf71 -0.47 -6.18 -0.32 1.94e-9 Developmental language disorder (linguistic errors); CRC cis rs7216064 1.000 rs12452511 chr17:65832576 A/G cg12091567 chr17:66097778 LOC651250 -0.67 -7.7 -0.39 1.65e-13 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CRC cis rs294883 0.826 rs447615 chr6:159698751 G/T cg14500486 chr6:159655392 FNDC1 -0.36 -5.82 -0.31 1.4e-8 Coronary artery disease; CRC trans rs7618501 0.669 rs7634084 chr3:49949834 A/T cg21659725 chr3:3221576 CRBN 0.54 8.39 0.42 1.5e-15 Intelligence (multi-trait analysis); CRC cis rs2576037 0.623 rs2571000 chr18:44580347 G/A cg23996704 chr18:44553084 KATNAL2 0.41 7.85 0.4 5.84e-14 Personality dimensions; CRC cis rs6502050 0.835 rs4789744 chr17:80101506 A/C cg02741985 chr17:80059408 CCDC57 0.43 7.15 0.37 5.66e-12 Life satisfaction; CRC cis rs10028773 0.546 rs13117947 chr4:120257060 A/G cg09307838 chr4:120376055 NA 0.53 8.01 0.4 1.99e-14 Educational attainment; CRC cis rs35110281 0.591 rs230642 chr21:44915533 A/C cg04455712 chr21:45112962 RRP1B -0.37 -6.97 -0.36 1.73e-11 Mean corpuscular volume; CRC cis rs7119 0.717 rs12916822 chr15:77818548 G/T cg10437265 chr15:77819839 NA 0.69 12.74 0.57 1.76e-30 Type 2 diabetes; CRC cis rs8072100 0.875 rs7208530 chr17:45544107 C/T cg25173405 chr17:45401733 C17orf57 -0.43 -6.57 -0.34 1.99e-10 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs4819052 1.000 rs28628220 chr21:46663741 G/C cg11663144 chr21:46675770 NA -0.8 -11.79 -0.54 5.51e-27 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs13256369 0.774 rs11777719 chr8:8581038 A/G cg06636001 chr8:8085503 FLJ10661 0.53 7.03 0.36 1.19e-11 Obesity-related traits; CRC trans rs6956675 1.000 rs10231112 chr7:62601257 A/G cg01314568 chr7:57830625 NA -0.7 -9.59 -0.47 2.31e-19 Obesity-related traits; CRC trans rs62103177 0.810 rs62103194 chr18:77629482 G/A cg05926928 chr17:57297772 GDPD1 1.06 9.98 0.48 1.12e-20 Opioid sensitivity; CRC cis rs2404602 0.716 rs56351018 chr15:76824591 T/C cg00316803 chr15:76480434 C15orf27 -0.36 -5.82 -0.31 1.39e-8 Blood metabolite levels; CRC cis rs12188164 0.965 rs11745789 chr5:450777 T/C cg17553881 chr5:443987 EXOC3;C5orf55 -0.37 -7.9 -0.4 4.09e-14 Cystic fibrosis severity; CRC cis rs7811142 0.943 rs67483801 chr7:100031758 G/T cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.62 8.34 0.42 2.09e-15 Platelet count; CRC cis rs743757 0.878 rs6786523 chr3:50524221 A/G cg08207895 chr3:50388901 TUSC4;CYB561D2 -0.42 -5.89 -0.31 9.39e-9 Diastolic blood pressure; CRC cis rs6496667 0.779 rs7163632 chr15:91039020 C/T cg04176472 chr15:90893244 GABARAPL3 0.53 7.64 0.39 2.33e-13 Rheumatoid arthritis; CRC cis rs55882075 0.750 rs13184690 chr5:179146993 T/C cg14593053 chr5:179126677 CANX 0.49 7.69 0.39 1.73e-13 Monocyte percentage of white cells; CRC cis rs10504229 0.906 rs903718 chr8:58167726 A/G cg05313129 chr8:58192883 C8orf71 -0.45 -7.41 -0.38 1.1e-12 Developmental language disorder (linguistic errors); CRC cis rs1448094 0.511 rs61930581 chr12:86157241 G/A cg25456477 chr12:86230367 RASSF9 0.39 6.45 0.34 3.89e-10 Major depressive disorder; CRC cis rs9583531 0.891 rs61969072 chr13:111380701 T/G cg24331049 chr13:111365604 ING1 -0.57 -6.24 -0.33 1.33e-9 Coronary artery disease; CRC cis rs62064224 0.902 rs17732573 chr17:30627664 C/T cg25809561 chr17:30822961 MYO1D -0.61 -10.98 -0.52 4.01e-24 Schizophrenia; CRC cis rs6502050 0.835 rs4789751 chr17:80092373 G/T cg09264619 chr17:80180166 NA -0.36 -5.99 -0.31 5.51e-9 Life satisfaction; CRC cis rs2276314 1.000 rs58054756 chr18:33554053 G/C cg05985134 chr18:33552581 C18orf21 0.47 6.51 0.34 2.78e-10 Endometriosis;Drug-induced torsades de pointes; CRC cis rs9733 0.744 rs11204725 chr1:150742700 T/C cg17724175 chr1:150552817 MCL1 -0.38 -5.77 -0.3 1.8e-8 Tonsillectomy; CRC cis rs6933660 0.646 rs6915598 chr6:151778664 T/C cg14416726 chr6:151773293 C6orf211;RMND1 -0.61 -8.22 -0.41 4.74e-15 Menarche (age at onset); CRC cis rs12291225 0.585 rs34171876 chr11:14353957 G/C cg05501817 chr11:14380813 RRAS2 -0.43 -5.84 -0.31 1.28e-8 Sense of smell; CRC cis rs561341 1.000 rs55736640 chr17:30333848 G/A cg00745463 chr17:30367425 LRRC37B -0.87 -9.55 -0.47 3.07e-19 Hip circumference adjusted for BMI; CRC cis rs9911578 1.000 rs304299 chr17:56838472 C/G cg12560992 chr17:57184187 TRIM37 0.9 16.65 0.68 1.38e-45 Intelligence (multi-trait analysis); CRC cis rs422249 0.547 rs174536 chr11:61551927 A/C cg06781209 chr11:61594997 FADS2 -0.38 -5.7 -0.3 2.61e-8 Trans fatty acid levels; CRC cis rs7772486 0.754 rs1415746 chr6:146077107 A/G cg23711669 chr6:146136114 FBXO30 -0.76 -13.29 -0.59 1.49e-32 Lobe attachment (rater-scored or self-reported); CRC cis rs950169 0.580 rs17598114 chr15:85171317 C/T cg11189052 chr15:85197271 WDR73 0.64 9.3 0.46 1.97e-18 Schizophrenia; CRC trans rs2303319 0.504 rs1006428 chr2:162592559 A/C cg10272801 chr16:14013773 ERCC4 -0.68 -6.07 -0.32 3.49e-9 Cognitive function; CRC cis rs7202877 0.610 rs468079 chr16:75428474 G/A cg03315344 chr16:75512273 CHST6 -0.5 -6.05 -0.32 3.99e-9 Type 2 diabetes;Type 1 diabetes; CRC cis rs9467711 0.659 rs35555795 chr6:26509382 C/T cg12315302 chr6:26189340 HIST1H4D 0.99 6.93 0.36 2.22e-11 Autism spectrum disorder or schizophrenia; CRC cis rs3858526 0.523 rs10769289 chr11:5886607 C/T cg05234568 chr11:5960015 NA -0.66 -9.72 -0.47 8.53e-20 DNA methylation (variation); CRC cis rs6570726 0.935 rs434298 chr6:145846873 G/A cg05347473 chr6:146136440 FBXO30 0.39 6.24 0.33 1.32e-9 Lobe attachment (rater-scored or self-reported); CRC trans rs2235573 0.594 rs12157609 chr22:38432277 C/T cg19894588 chr14:64061835 NA 0.41 5.99 0.31 5.52e-9 Glioblastoma;Glioma; CRC trans rs8073060 0.586 rs72829923 chr17:34045089 T/A cg19694781 chr19:47549865 TMEM160 1.08 14.73 0.63 4.38e-38 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; CRC cis rs6540556 0.724 rs6679631 chr1:209935491 C/A cg23920097 chr1:209922102 NA -0.52 -6.59 -0.34 1.72e-10 Red blood cell count; CRC cis rs4731207 0.735 rs720616 chr7:124452961 A/G cg23710748 chr7:124431027 NA 0.38 6.08 0.32 3.42e-9 Cutaneous malignant melanoma; CRC cis rs669446 0.533 rs7543520 chr1:44243866 T/C cg12908607 chr1:44402522 ARTN -0.35 -5.99 -0.31 5.56e-9 Amyotrophic lateral sclerosis (age of onset); CRC cis rs875971 0.505 rs1167386 chr7:65513096 G/A cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.51 -7.67 -0.39 1.98e-13 Aortic root size; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg12982440 chr20:36661586 RPRD1B;KIAA0406 0.5 6.48 0.34 3.27e-10 Thyroid stimulating hormone; CRC cis rs7666738 0.800 rs10008654 chr4:98820498 C/A cg17366294 chr4:99064904 C4orf37 0.43 6.89 0.36 2.79e-11 Colonoscopy-negative controls vs population controls; CRC cis rs9463078 0.838 rs9357470 chr6:45065613 C/T cg25276700 chr6:44698697 NA -0.29 -6.99 -0.36 1.55e-11 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; CRC cis rs9372498 0.536 rs9489457 chr6:118920285 C/T cg15382696 chr6:118971807 C6orf204 0.6 7.72 0.39 1.38e-13 Diastolic blood pressure; CRC cis rs2153535 0.580 rs1932276 chr6:8442593 G/A cg21535247 chr6:8435926 SLC35B3 0.48 7.24 0.37 3.19e-12 Motion sickness; CRC cis rs728616 1.000 rs728615 chr10:81848089 G/A cg05935833 chr10:81318306 SFTPA2 -0.55 -6.55 -0.34 2.18e-10 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs394563 0.589 rs1900300 chr6:149641627 T/C cg16235748 chr6:149772707 ZC3H12D 0.35 6.23 0.33 1.39e-9 Dupuytren's disease; CRC cis rs733592 0.560 rs61918773 chr12:48421774 G/A cg21466736 chr12:48725269 NA 0.45 6.99 0.36 1.54e-11 Plateletcrit; CRC trans rs7267979 1.000 rs2027004 chr20:25350618 C/T cg17903999 chr18:56338584 MALT1 0.41 6.66 0.34 1.14e-10 Liver enzyme levels (alkaline phosphatase); CRC cis rs738322 0.600 rs7286105 chr22:38557821 A/G cg25457927 chr22:38595422 NA -0.32 -6.6 -0.34 1.6e-10 Cutaneous nevi; CRC cis rs76419734 0.510 rs2553446 chr4:106696476 G/A cg24545054 chr4:106630052 GSTCD;INTS12 -0.55 -6.28 -0.33 1.07e-9 Post bronchodilator FEV1; CRC cis rs9311474 0.629 rs7639267 chr3:52568805 G/T cg17372223 chr3:52568218 NT5DC2 0.41 6.37 0.33 6.34e-10 Electroencephalogram traits; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg02273166 chr14:105487914 CDCA4 0.43 6.15 0.32 2.22e-9 Intelligence (multi-trait analysis); CRC cis rs6964587 0.869 rs6975243 chr7:91514672 G/A cg17063962 chr7:91808500 NA -0.72 -11.79 -0.54 5.33e-27 Breast cancer; CRC trans rs2303319 0.582 rs62187614 chr2:162436285 C/G cg09481857 chr22:21368659 P2RX6;MGC16703 -0.65 -6.0 -0.31 5.13e-9 Cognitive function; CRC cis rs9467711 0.651 rs16891264 chr6:26072445 C/T cg19084075 chr6:26124329 HIST1H2AC;HIST1H2BC -0.76 -6.72 -0.35 8.2e-11 Autism spectrum disorder or schizophrenia; CRC cis rs11212617 0.935 rs227055 chr11:108261261 G/A cg01991180 chr11:108092276 ATM;NPAT 0.43 6.33 0.33 7.86e-10 Response to metformin in type 2 diabetes (glycemic); CRC cis rs7149337 0.773 rs3007067 chr14:51596420 G/A cg23942311 chr14:51606299 NA 0.84 17.26 0.69 5.3e-48 Cancer; CRC cis rs7674212 0.539 rs6533056 chr4:104120997 T/C cg16532752 chr4:104119610 CENPE -0.41 -5.78 -0.3 1.77e-8 Type 2 diabetes; CRC cis rs6582630 0.555 rs11613249 chr12:38519339 T/C cg26384229 chr12:38710491 ALG10B 0.71 10.06 0.48 6.25e-21 Drug-induced liver injury (flucloxacillin); CRC cis rs3785574 0.962 rs2247435 chr17:61892862 G/A cg22520471 chr17:61851767 DDX42;CCDC47 0.47 6.37 0.33 6.35e-10 Height; CRC cis rs16852403 0.517 rs12733805 chr1:178249853 C/A cg00404053 chr1:178313656 RASAL2 0.48 6.12 0.32 2.7e-9 Childhood ear infection; CRC cis rs7412746 0.658 rs1027699 chr1:150811712 T/C cg10589385 chr1:150898437 SETDB1 0.31 6.47 0.34 3.52e-10 Melanoma; CRC cis rs12142240 0.698 rs6429599 chr1:46827871 G/A cg00530320 chr1:46809349 NSUN4 0.59 8.1 0.41 1.06e-14 Menopause (age at onset); CRC cis rs6570726 0.935 rs401888 chr6:145831535 A/G cg05347473 chr6:146136440 FBXO30 0.37 6.0 0.31 5.27e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs780096 0.546 rs4665976 chr2:27640325 A/G cg21248554 chr2:27665150 KRTCAP3 -0.31 -7.35 -0.38 1.59e-12 Total body bone mineral density; CRC cis rs10140922 0.966 rs10132397 chr14:35822447 G/T cg07166546 chr14:35805898 NA -0.3 -6.04 -0.32 4.1e-9 Hip circumference adjusted for BMI; CRC cis rs1862618 0.525 rs2662021 chr5:56261691 C/T cg03609598 chr5:56110824 MAP3K1 0.67 7.88 0.4 4.91e-14 Initial pursuit acceleration; CRC cis rs7917772 0.582 rs10786684 chr10:104323028 A/C cg11453585 chr10:104263688 ACTR1A;SUFU -0.8 -14.37 -0.62 1.14e-36 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC cis rs9583531 0.689 rs9521913 chr13:111382058 C/T cg24331049 chr13:111365604 ING1 -0.52 -6.83 -0.35 4.13e-11 Coronary artery disease; CRC cis rs72634258 0.945 rs12735338 chr1:8078569 T/C cg00042356 chr1:8021962 PARK7 0.67 7.4 0.38 1.18e-12 Inflammatory bowel disease; CRC trans rs2303319 0.504 rs62189048 chr2:162613494 G/C cg04551154 chr10:95462393 C10orf4 -0.75 -6.37 -0.33 6.43e-10 Cognitive function; CRC cis rs780096 0.526 rs780117 chr2:27698343 C/G cg27432699 chr2:27873401 GPN1 -0.52 -7.96 -0.4 2.91e-14 Total body bone mineral density; CRC cis rs2257205 0.667 rs7211439 chr17:56847832 A/T cg25885038 chr17:56607967 SEPT4 -0.53 -5.75 -0.3 2.07e-8 Pancreatic cancer; CRC cis rs796364 0.951 rs59695400 chr2:201021325 C/T cg12253985 chr2:200820533 C2orf60;C2orf47 -0.52 -5.76 -0.3 1.96e-8 Schizophrenia; CRC cis rs6933660 0.800 rs13201167 chr6:151773504 T/C cg14262678 chr6:151773367 RMND1;C6orf211 0.55 9.08 0.45 1.04e-17 Menarche (age at onset); CRC cis rs10751667 0.666 rs7395823 chr11:942701 T/C cg23136738 chr11:925521 AP2A2 -0.42 -6.98 -0.36 1.65e-11 Alzheimer's disease (late onset); CRC cis rs4664293 0.867 rs13415025 chr2:160586310 C/T cg08347373 chr2:160653686 CD302 -0.47 -7.52 -0.38 5.31e-13 Monocyte percentage of white cells; CRC cis rs11758351 1.000 rs76329209 chr6:26196430 A/G cg01420254 chr6:26195488 NA 0.83 8.68 0.43 1.82e-16 Gout;Renal underexcretion gout; CRC cis rs883565 0.502 rs4374473 chr3:38942618 C/T cg01426195 chr3:39028469 NA 0.38 6.37 0.33 6.34e-10 Handedness; CRC cis rs11122272 0.701 rs743120 chr1:231531232 C/T cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.58 -8.72 -0.43 1.37e-16 Hemoglobin concentration; CRC cis rs11864453 0.680 rs8047377 chr16:72148339 T/C cg23815491 chr16:72088622 HP 0.51 7.9 0.4 4.32e-14 Fibrinogen levels; CRC cis rs6952808 0.689 rs4719391 chr7:2048136 T/C cg22963979 chr7:1858916 MAD1L1 -0.48 -7.08 -0.36 8.88e-12 Bipolar disorder and schizophrenia; CRC cis rs1577917 0.917 rs35738006 chr6:86646309 C/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.52 -6.47 -0.34 3.52e-10 Response to antipsychotic treatment; CRC cis rs7208859 0.725 rs9915802 chr17:29173058 T/C cg14008862 chr17:28927542 LRRC37B2 0.5 6.08 0.32 3.32e-9 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg07822143 chr4:146019674 ABCE1;ANAPC10 0.42 6.16 0.32 2.16e-9 Intelligence (multi-trait analysis); CRC cis rs2688608 0.592 rs7923045 chr10:75487498 A/T cg23231163 chr10:75533350 FUT11 -0.37 -5.84 -0.31 1.26e-8 Inflammatory bowel disease; CRC cis rs1552244 0.882 rs113268531 chr3:10167069 A/G cg02579736 chr3:10068473 FANCD2;CIDECP 1.01 13.32 0.59 1.17e-32 Alzheimer's disease; CRC cis rs2243480 1.000 rs2961102 chr7:65424658 A/G cg25985355 chr7:65971099 NA -0.49 -5.87 -0.31 1.05e-8 Diabetic kidney disease; CRC cis rs977987 0.835 rs3851733 chr16:75370263 G/C cg03315344 chr16:75512273 CHST6 0.51 8.65 0.43 2.36e-16 Dupuytren's disease; CRC cis rs9303401 0.538 rs2240258 chr17:56458183 C/A cg10487724 chr17:56770010 TEX14;RAD51C 0.7 8.06 0.41 1.44e-14 Cognitive test performance; CRC trans rs1814175 0.817 rs7109440 chr11:49966296 C/T cg15704280 chr7:45808275 SEPT13 -0.97 -18.48 -0.71 8.63e-53 Height; CRC cis rs2354432 0.607 rs7523812 chr1:146673489 A/G cg25205988 chr1:146714368 CHD1L -1.08 -9.67 -0.47 1.28e-19 Mitochondrial DNA levels; CRC cis rs4665809 1.000 rs750452 chr2:26324995 G/A cg04944784 chr2:26401820 FAM59B -0.6 -7.67 -0.39 1.98e-13 Gut microbiome composition (summer); CRC cis rs7769051 1.000 rs3813347 chr6:133119778 G/A cg07930552 chr6:133119739 C6orf192 0.72 8.69 0.43 1.76e-16 Type 2 diabetes nephropathy; CRC cis rs3812111 0.524 rs12193094 chr6:116540395 C/T cg18764771 chr6:116381957 FRK 0.25 5.89 0.31 9.61e-9 Age-related macular degeneration; CRC cis rs6951245 0.638 rs74976697 chr7:1160505 C/T cg04025307 chr7:1156635 C7orf50 0.66 7.56 0.38 4.01e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs1728785 1.000 rs1728785 chr16:68591230 G/T cg02972257 chr16:68554789 NA 0.65 7.68 0.39 1.79e-13 Ulcerative colitis; CRC cis rs172166 0.694 rs1631552 chr6:28089699 C/A cg20615401 chr6:28092323 ZSCAN16 0.46 6.07 0.32 3.55e-9 Cardiac Troponin-T levels; CRC cis rs10751667 0.961 rs7395928 chr11:952605 T/G ch.11.42038R chr11:967971 AP2A2 0.69 11.56 0.54 3.73e-26 Alzheimer's disease (late onset); CRC cis rs8180040 0.934 rs12630641 chr3:47534836 G/T cg10298567 chr3:47292165 KIF9 -0.36 -5.91 -0.31 8.73e-9 Colorectal cancer; CRC cis rs4819052 0.851 rs2838849 chr21:46671027 A/G cg11663144 chr21:46675770 NA -0.86 -15.13 -0.64 1.24e-39 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs7824557 0.564 rs2736288 chr8:11228100 G/A cg20542592 chr8:11973495 FAM66D 0.33 5.79 0.3 1.6e-8 Retinal vascular caliber; CRC cis rs7917772 0.715 rs7077678 chr10:104438565 C/T cg11453585 chr10:104263688 ACTR1A;SUFU 0.54 7.71 0.39 1.55e-13 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC cis rs7587476 1.000 rs3768707 chr2:215645135 C/T cg04004882 chr2:215674386 BARD1 0.48 6.31 0.33 9.24e-10 Neuroblastoma; CRC cis rs1008375 1.000 rs4235388 chr4:17682030 G/A cg04450456 chr4:17643702 FAM184B 0.41 6.52 0.34 2.6e-10 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs9399137 0.507 rs10484496 chr6:135299682 T/C cg24558204 chr6:135376177 HBS1L 0.61 9.23 0.45 3.43e-18 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; CRC trans rs2727020 0.729 rs4980439 chr11:49342246 G/C cg11707556 chr5:10655725 ANKRD33B -0.35 -6.69 -0.35 9.81e-11 Coronary artery disease; CRC trans rs10982213 0.830 rs2274163 chr9:117188714 C/T cg12277888 chr11:35723985 TRIM44 -0.42 -6.88 -0.35 2.95e-11 Interleukin-6 levels; CRC cis rs9902453 0.933 rs7224199 chr17:28523726 G/T cg26525008 chr17:28256777 EFCAB5;SSH2 0.6 8.82 0.44 6.72e-17 Coffee consumption (cups per day); CRC cis rs7843479 0.601 rs10866837 chr8:21861663 G/C cg17168535 chr8:21777572 XPO7 0.59 9.84 0.48 3.36e-20 Mean corpuscular volume; CRC cis rs731174 1.000 rs731174 chr1:38196841 C/T cg06917450 chr1:38156652 C1orf109 0.46 6.67 0.35 1.06e-10 Prostate cancer (SNP x SNP interaction); CRC cis rs7412746 0.566 rs2864871 chr1:150766964 T/C cg10589385 chr1:150898437 SETDB1 0.31 6.31 0.33 9.16e-10 Melanoma; CRC trans rs61931739 0.517 rs4931771 chr12:34044557 G/A cg26384229 chr12:38710491 ALG10B 0.53 6.76 0.35 6.43e-11 Morning vs. evening chronotype; CRC cis rs57221529 0.766 rs58015612 chr5:580665 A/T cg14541582 chr5:601475 NA -0.37 -7.19 -0.37 4.49e-12 Lung disease severity in cystic fibrosis; CRC cis rs9649213 0.574 rs13238610 chr7:97909277 T/C cg24562669 chr7:97807699 LMTK2 0.45 7.63 0.39 2.6e-13 Prostate cancer (SNP x SNP interaction); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T ch.1.4829111R chr1:242658279 PLD5 0.4 5.97 0.31 6.28e-9 Intelligence (multi-trait analysis); CRC cis rs8062405 0.755 rs111693583 chr16:28583610 C/T cg16576597 chr16:28551801 NUPR1 0.55 8.11 0.41 1.05e-14 Cognitive ability (multi-trait analysis);Cognitive ability; CRC cis rs2303745 0.544 rs6512180 chr19:17399153 C/T cg02221750 chr19:17393354 ANKLE1 -0.45 -6.74 -0.35 7.17e-11 Systemic lupus erythematosus; CRC cis rs853679 0.517 rs9380062 chr6:28137569 G/A cg06470822 chr6:28175283 NA 1.03 13.59 0.6 1.04e-33 Depression; CRC cis rs3617 0.573 rs9825230 chr3:52901974 G/A cg07507251 chr3:52567010 NT5DC2 0.39 5.73 0.3 2.31e-8 Red blood cell count;Autism spectrum disorder or schizophrenia; CRC cis rs13191362 1.000 rs34714518 chr6:163080778 G/A cg23758597 chr6:163146217 PARK2 -0.65 -6.52 -0.34 2.68e-10 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs9467711 0.591 rs13203673 chr6:25979122 T/C cg08501292 chr6:25962987 TRIM38 1.08 9.05 0.45 1.3e-17 Autism spectrum disorder or schizophrenia; CRC cis rs55665837 1.000 rs10832256 chr11:14442875 G/A cg19336497 chr11:14380999 RRAS2 -0.39 -6.61 -0.34 1.58e-10 Vitamin D levels; CRC cis rs1552244 1.000 rs6442148 chr3:10078289 G/C cg13047869 chr3:10149882 C3orf24 0.53 7.61 0.39 2.93e-13 Alzheimer's disease; CRC cis rs6589219 0.908 rs7103178 chr11:111165009 C/T cg25129781 chr11:111156908 C11orf53 -0.31 -5.82 -0.31 1.41e-8 Colorectal cancer; CRC cis rs7666738 0.830 rs1426662 chr4:98990319 C/T cg17366294 chr4:99064904 C4orf37 0.43 7.27 0.37 2.64e-12 Colonoscopy-negative controls vs population controls; CRC cis rs2239547 0.562 rs35380116 chr3:52979178 A/G cg11645453 chr3:52864694 ITIH4 -0.52 -9.73 -0.47 8.06e-20 Schizophrenia; CRC trans rs7267979 1.000 rs4815409 chr20:25346697 C/A cg17903999 chr18:56338584 MALT1 0.42 7.01 0.36 1.37e-11 Liver enzyme levels (alkaline phosphatase); CRC cis rs7085104 0.552 rs11191414 chr10:104601565 A/T cg15744005 chr10:104629667 AS3MT -0.35 -7.34 -0.38 1.7e-12 Immature fraction of reticulocytes;Schizophrenia; CRC cis rs12286929 0.780 rs2187986 chr11:115001410 C/T cg04055981 chr11:115044050 NA 0.37 5.8 0.3 1.54e-8 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC trans rs10982213 0.830 rs2274163 chr9:117188714 C/T cg13540147 chr9:140131233 NA 0.41 6.02 0.31 4.56e-9 Interleukin-6 levels; CRC cis rs951366 0.789 rs1772148 chr1:205704580 A/T cg14893161 chr1:205819251 PM20D1 0.82 13.01 0.58 1.61e-31 Menarche (age at onset); CRC cis rs7605827 0.930 rs10929375 chr2:15684483 A/G cg19274914 chr2:15703543 NA 0.39 5.82 0.31 1.4e-8 Educational attainment (years of education); CRC cis rs823143 0.570 rs823082 chr1:205786935 C/T cg23034840 chr1:205782522 SLC41A1 -0.65 -10.41 -0.5 3.86e-22 Monocyte percentage of white cells; CRC cis rs10256972 0.706 rs12701970 chr7:1121958 T/C cg09177884 chr7:1199841 ZFAND2A -0.42 -5.92 -0.31 8.23e-9 Longevity;Endometriosis; CRC cis rs9788721 0.836 rs1504550 chr15:78766250 A/G cg18825076 chr15:78729989 IREB2 -0.48 -7.03 -0.36 1.23e-11 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio;Emphysema imaging phenotypes;Emphysema distribution in smoking;Local histogram emphysema pattern;Post bronchodilator FEV1/FVC ratio in COPD; CRC cis rs10540 1.000 rs61876342 chr11:496193 T/G cg08200582 chr11:442649 ANO9 -0.71 -7.42 -0.38 9.82e-13 Body mass index; CRC cis rs7274811 0.744 rs2071054 chr20:32265839 A/G cg03904042 chr20:32255491 NECAB3;C20orf134 -0.48 -6.77 -0.35 6.05e-11 Height; CRC cis rs250677 0.687 rs40149 chr5:148444275 A/T cg23229984 chr5:148520753 ABLIM3 0.5 6.83 0.35 4.04e-11 Breast cancer; CRC cis rs28493229 0.708 rs111410535 chr19:41158441 C/T cg21869046 chr19:41225005 ITPKC 0.42 6.39 0.33 5.78e-10 Kawasaki disease; CRC cis rs6763159 0.566 rs9876719 chr3:59654569 G/A cg07069742 chr3:59644285 NA -0.46 -8.63 -0.43 2.65e-16 Conotruncal heart defects; CRC trans rs877282 0.853 rs7079299 chr10:756455 A/G cg22713356 chr15:30763199 NA 1.19 13.88 0.61 8.17e-35 Uric acid levels; CRC cis rs7249142 0.562 rs1050544 chr19:19287901 A/G cg08207377 chr19:19281140 LOC729991-MEF2B;MEF2B -0.36 -5.91 -0.31 8.49e-9 IgG glycosylation; CRC cis rs3932549 1 rs3932549 chr9:97073588 A/C cg04523069 chr9:97136363 HIATL1 -0.37 -5.63 -0.3 3.95e-8 Body mass index; CRC trans rs2470578 0.716 rs2733514 chr3:17323931 A/G cg01842685 chr12:56123602 CD63 -0.45 -6.42 -0.33 4.87e-10 Schizophrenia; CRC cis rs17023223 0.581 rs11811859 chr1:119707680 A/G cg05756136 chr1:119680316 WARS2 -0.52 -7.14 -0.37 6e-12 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for BMI in active individuals; CRC cis rs951366 0.789 rs7536483 chr1:205718858 A/T cg23034840 chr1:205782522 SLC41A1 0.47 6.43 0.33 4.37e-10 Menarche (age at onset); CRC cis rs6089584 0.816 rs6061410 chr20:60625329 A/G cg23463467 chr20:60627584 TAF4 0.36 6.4 0.33 5.45e-10 Body mass index; CRC cis rs7408868 1.000 rs7250232 chr19:15277199 C/T cg14696996 chr19:15285081 NOTCH3 0.94 8.79 0.44 8.6e-17 Pulse pressure; CRC trans rs701145 0.617 rs7426835 chr3:154049539 C/T cg22545385 chr10:131989303 NA -0.43 -6.3 -0.33 9.34e-10 Coronary artery disease; CRC cis rs72781680 0.851 rs72796397 chr2:24178211 T/A cg08917208 chr2:24149416 ATAD2B 0.9 9.17 0.45 5.14e-18 Lymphocyte counts; CRC cis rs3790844 0.613 rs12030331 chr1:200001547 G/A cg07208853 chr1:200005219 NR5A2 0.35 8.82 0.44 6.67e-17 Pancreatic cancer; CRC cis rs968567 0.817 rs61896141 chr11:61556039 A/C cg00603274 chr11:61596626 FADS2 -0.86 -10.31 -0.49 9.08e-22 Blood metabolite levels;Rheumatoid arthritis;Vitiligo;Glycerophospholipid levels; CRC cis rs62432291 0.681 rs404435 chr6:159654487 G/T cg14500486 chr6:159655392 FNDC1 -0.77 -10.45 -0.5 3.02e-22 Joint mobility (Beighton score); CRC cis rs6502050 0.871 rs9916649 chr17:80075739 G/A cg09264619 chr17:80180166 NA 0.36 5.92 0.31 8.22e-9 Life satisfaction; CRC cis rs3617 0.573 rs9825230 chr3:52901974 G/A cg05573699 chr3:52720067 GNL3;PBRM1 -0.42 -6.17 -0.32 2.01e-9 Red blood cell count;Autism spectrum disorder or schizophrenia; CRC cis rs4731207 0.596 rs10256218 chr7:124609982 C/G cg23710748 chr7:124431027 NA -0.39 -6.25 -0.33 1.29e-9 Cutaneous malignant melanoma; CRC cis rs270601 0.955 rs273911 chr5:131661526 C/G cg09877947 chr5:131593287 PDLIM4 0.44 7.22 0.37 3.68e-12 Acylcarnitine levels; CRC cis rs477895 0.713 rs882146 chr11:63976699 G/A cg23719950 chr11:63933701 MACROD1 -0.68 -8.56 -0.43 4.35e-16 Mean platelet volume; CRC cis rs1448094 0.621 rs7315084 chr12:86283817 A/G cg02569458 chr12:86230093 RASSF9 0.36 6.09 0.32 3.1e-9 Major depressive disorder; CRC cis rs8060686 0.858 rs7187289 chr16:67967878 A/C cg01951491 chr16:67709440 GFOD2 -0.45 -5.66 -0.3 3.36e-8 HDL cholesterol;Metabolic syndrome; CRC cis rs9322193 0.962 rs9505974 chr6:150100430 C/T cg13206674 chr6:150067644 NUP43 0.54 7.76 0.39 1.11e-13 Lung cancer; CRC cis rs10746514 0.804 rs1854822 chr1:232262270 G/C cg09506761 chr1:232265262 NA -0.46 -6.67 -0.34 1.11e-10 Response to statin therapy; CRC cis rs7932354 0.528 rs4752957 chr11:47125632 T/G cg03339077 chr11:47165057 C11orf49 0.45 6.31 0.33 8.83e-10 Bone mineral density (hip);Bone mineral density; CRC cis rs10504073 0.647 rs4873096 chr8:49995201 A/G cg00325661 chr8:49890786 NA 0.52 9.27 0.45 2.57e-18 Blood metabolite ratios; CRC trans rs7395662 1.000 rs7481880 chr11:48609347 C/T cg21153622 chr11:89784906 NA -0.45 -7.21 -0.37 3.98e-12 HDL cholesterol; CRC cis rs9326248 0.559 rs476399 chr11:116733728 T/C cg26566898 chr11:117069891 TAGLN 0.27 5.85 0.31 1.2e-8 Blood protein levels; CRC trans rs703108 0.731 rs7898954 chr10:22323646 A/G cg24910938 chr20:47835804 DDX27 -0.48 -6.56 -0.34 2.13e-10 Monocyte percentage of white cells; CRC cis rs959260 0.528 rs9909443 chr17:73308346 C/T cg14668889 chr17:73230827 NUP85 0.66 9.15 0.45 6.11e-18 Systemic lupus erythematosus; CRC trans rs1814175 0.615 rs12417290 chr11:49876951 G/A cg11707556 chr5:10655725 ANKRD33B -0.52 -10.01 -0.48 9.28e-21 Height; CRC cis rs6951245 0.872 rs77434655 chr7:1098405 G/A cg22907277 chr7:1156413 C7orf50 0.73 7.68 0.39 1.78e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs9389248 0.690 rs6939543 chr6:135255143 A/G cg24558204 chr6:135376177 HBS1L -0.54 -7.95 -0.4 3.04e-14 High light scatter reticulocyte percentage of red cells; CRC cis rs7617773 0.539 rs11130165 chr3:48384721 G/T cg11946769 chr3:48343235 NME6 0.61 8.23 0.41 4.33e-15 Coronary artery disease; CRC cis rs6912958 0.559 rs242279 chr6:88048191 A/G cg08069147 chr6:88032118 GJB7;C6orf162 0.69 11.1 0.52 1.55e-24 Monocyte percentage of white cells; CRC cis rs9399137 0.507 rs6569986 chr6:135311641 T/C cg22676075 chr6:135203613 NA 0.59 9.01 0.45 1.66e-17 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; CRC cis rs7208859 0.623 rs59029591 chr17:29235746 A/C cg14008862 chr17:28927542 LRRC37B2 0.56 5.8 0.3 1.6e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs10504229 0.683 rs11786074 chr8:58133532 A/G cg02290350 chr8:58132656 NA -0.58 -8.16 -0.41 7.29e-15 Developmental language disorder (linguistic errors); CRC cis rs9925964 0.933 rs749671 chr16:31088347 G/A cg03418659 chr16:31128414 MYST1 0.5 6.94 0.36 2.07e-11 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs4903604 0.581 rs12879719 chr14:78035253 C/A cg18872420 chr14:78023429 SPTLC2 0.34 5.92 0.31 7.9e-9 Gut microbiome composition (winter); CRC cis rs10464366 0.912 rs6979668 chr7:39104228 G/A cg15212455 chr7:39170539 POU6F2 0.45 5.69 0.3 2.82e-8 IgG glycosylation; CRC cis rs6952808 0.724 rs7792631 chr7:1982779 C/T cg00106254 chr7:1943704 MAD1L1 -0.5 -7.02 -0.36 1.25e-11 Bipolar disorder and schizophrenia; CRC cis rs4930103 0.904 rs4929984 chr11:2024683 A/C cg06197492 chr11:2016605 H19 -0.38 -5.69 -0.3 2.85e-8 DNA methylation (parent-of-origin);DNA methylation (variation); CRC trans rs4714291 0.775 rs2949019 chr6:40051200 C/T cg02267698 chr19:7991119 CTXN1 -0.51 -7.05 -0.36 1.05e-11 Strep throat; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg15665968 chr21:44527764 U2AF1 0.46 6.49 0.34 3.21e-10 Anxiety disorder; CRC cis rs9916302 0.706 rs9909304 chr17:37500508 G/T cg15445000 chr17:37608096 MED1 -0.36 -6.33 -0.33 7.84e-10 Glomerular filtration rate (creatinine); CRC cis rs5758659 0.652 rs133347 chr22:42423645 A/T cg04733989 chr22:42467013 NAGA 0.41 5.69 0.3 2.86e-8 Cognitive function; CRC cis rs7618915 0.547 rs7642198 chr3:52677960 T/C cg11645453 chr3:52864694 ITIH4 0.36 6.25 0.33 1.29e-9 Bipolar disorder; CRC cis rs1552244 0.816 rs56271597 chr3:10042790 C/T cg13047869 chr3:10149882 C3orf24 0.53 7.15 0.37 5.67e-12 Alzheimer's disease; CRC cis rs4713118 0.911 rs9295746 chr6:27730064 T/C cg12172441 chr6:28176163 NA 0.55 6.55 0.34 2.16e-10 Parkinson's disease; CRC cis rs870825 0.929 rs1405940 chr4:185591481 A/G cg04058563 chr4:185651563 MLF1IP 0.69 7.2 0.37 4.09e-12 Blood protein levels; CRC cis rs2239547 0.657 rs7620706 chr3:52891756 A/T cg10802521 chr3:52805072 NEK4 -0.47 -6.25 -0.33 1.28e-9 Schizophrenia; CRC cis rs1552244 0.872 rs35988239 chr3:10074145 G/T cg18598329 chr3:10140678 FANCD2;C3orf24 -0.94 -10.94 -0.52 5.89e-24 Alzheimer's disease; CRC cis rs7552404 0.690 rs12723575 chr1:76335203 T/C cg10523679 chr1:76189770 ACADM -0.67 -8.76 -0.43 1.05e-16 Blood metabolite levels;Acylcarnitine levels; CRC cis rs7640424 0.620 rs71321252 chr3:107813107 A/C cg09227934 chr3:107805635 CD47 -0.51 -6.43 -0.33 4.53e-10 Body mass index; CRC cis rs172166 0.694 rs203884 chr6:28077374 G/T cg23161317 chr6:28129485 ZNF389 0.43 6.06 0.32 3.76e-9 Cardiac Troponin-T levels; CRC cis rs2204008 0.837 rs7301679 chr12:37989629 T/C cg13010199 chr12:38710504 ALG10B -0.49 -7.25 -0.37 3.03e-12 Bladder cancer; CRC cis rs501120 0.564 rs2802482 chr10:44675851 A/G cg09554077 chr10:44749378 NA 0.5 6.91 0.36 2.6e-11 Coronary artery disease;Coronary heart disease; CRC cis rs9296092 0.521 rs9461886 chr6:33526770 T/C cg13560919 chr6:33536144 NA -0.44 -6.28 -0.33 1.09e-9 Age at smoking initiation in chronic obstructive pulmonary disease; CRC cis rs6502050 0.761 rs13949 chr17:80059596 T/C cg02741985 chr17:80059408 CCDC57 -0.45 -7.18 -0.37 4.55e-12 Life satisfaction; CRC cis rs7666738 0.753 rs9991512 chr4:99007205 T/C cg05340658 chr4:99064831 C4orf37 0.61 9.54 0.47 3.44e-19 Colonoscopy-negative controls vs population controls; CRC trans rs6703335 0.870 rs10803142 chr1:243598234 A/G cg25962774 chr5:176831364 F12 0.42 5.99 0.31 5.61e-9 Schizophrenia;Schizophrenia, schizoaffective disorder or bipolar disorder; CRC cis rs9611565 0.694 rs202656 chr22:41842203 T/A cg06481639 chr22:41940642 POLR3H 0.53 5.74 0.3 2.2e-8 Vitiligo; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg01525597 chr12:1739061 WNT5B 0.47 6.9 0.36 2.61e-11 Intelligence (multi-trait analysis); CRC trans rs1814175 0.684 rs1827015 chr11:49585241 A/G cg03929089 chr4:120376271 NA -0.81 -13.15 -0.59 4.86e-32 Height; CRC cis rs8067545 0.750 rs36077949 chr17:19985782 C/T cg13482628 chr17:19912719 NA 0.47 7.65 0.39 2.24e-13 Schizophrenia; CRC cis rs7508679 1.000 rs10401485 chr19:7222234 T/C cg09779027 chr19:7224513 INSR 1.0 21.42 0.76 2.46e-64 Hypothyroidism; CRC cis rs28386778 0.897 rs2597634 chr17:61878144 G/A cg11494091 chr17:61959527 GH2 0.62 10.57 0.5 1.13e-22 Prudent dietary pattern; CRC cis rs7635838 0.503 rs9853547 chr3:11396101 C/G cg00170343 chr3:11313890 ATG7 0.44 6.68 0.35 1.05e-10 HDL cholesterol; CRC cis rs8064299 0.967 rs878906 chr17:72769334 T/C cg25054828 chr17:72772726 NAT9;TMEM104 0.63 10.06 0.49 6.18e-21 Monocyte count; CRC cis rs7224737 1.000 rs2014521 chr17:40283413 C/G cg02228675 chr17:40259724 DHX58 -0.5 -7.01 -0.36 1.38e-11 Fibrinogen levels; CRC cis rs1577917 0.637 rs1838957 chr6:86565056 T/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.44 -5.78 -0.3 1.75e-8 Response to antipsychotic treatment; CRC cis rs7493 0.755 rs116306774 chr7:95016976 G/A cg07404485 chr7:94953653 PON1 -0.43 -5.64 -0.3 3.62e-8 Yu-Zhi constitution type in type 2 diabetes; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg06880365 chr19:36870044 NA 0.4 6.57 0.34 1.93e-10 Liver disease severity in Alagille syndrome; CRC cis rs597539 0.652 rs559032 chr11:68710847 G/T cg21963583 chr11:68658836 MRPL21 0.59 10.5 0.5 1.88e-22 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC trans rs66887589 0.592 rs62320740 chr4:120279486 C/A cg25214090 chr10:38739885 LOC399744 0.4 6.06 0.32 3.72e-9 Diastolic blood pressure; CRC cis rs524281 0.773 rs11227448 chr11:66048491 G/A cg16950941 chr11:66035639 RAB1B -0.73 -8.15 -0.41 7.81e-15 Electroencephalogram traits; CRC cis rs1552244 1.000 rs2160869 chr3:10079255 G/A cg13047869 chr3:10149882 C3orf24 0.53 7.61 0.39 2.93e-13 Alzheimer's disease; CRC cis rs7666738 0.830 rs35235971 chr4:98999833 G/T cg05340658 chr4:99064831 C4orf37 0.61 9.54 0.47 3.44e-19 Colonoscopy-negative controls vs population controls; CRC cis rs12500482 0.935 rs2239736 chr4:2438929 T/C cg26605046 chr4:2439731 NA -0.41 -7.28 -0.37 2.49e-12 Cognitive function; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg03132935 chr11:118901768 SLC37A4 0.45 6.3 0.33 9.6e-10 Response to antipsychotic treatment; CRC cis rs7937682 0.737 rs682239 chr11:111425105 A/G cg19812747 chr11:111475976 SIK2 0.49 8.28 0.42 3.03e-15 Primary sclerosing cholangitis; CRC trans rs57221529 0.709 rs72707024 chr5:667915 G/A cg25482853 chr8:67687455 SGK3 1.01 10.95 0.52 5.47e-24 Lung disease severity in cystic fibrosis; CRC cis rs853679 0.517 rs6922063 chr6:28094366 G/A cg12273811 chr6:28175739 NA 0.71 9.14 0.45 6.45e-18 Depression; CRC cis rs1545257 0.505 rs7595372 chr2:24632122 A/C cg06627628 chr2:24431161 ITSN2 -0.43 -6.37 -0.33 6.52e-10 Sjögren's syndrome; CRC cis rs2576037 0.583 rs8098948 chr18:44512332 C/A cg19077165 chr18:44547161 KATNAL2 -0.71 -12.05 -0.55 5.95e-28 Personality dimensions; CRC cis rs2239547 0.657 rs3755803 chr3:52866157 C/G cg10802521 chr3:52805072 NEK4 -0.45 -6.1 -0.32 3.05e-9 Schizophrenia; CRC cis rs739401 0.572 rs7111857 chr11:3068106 A/G cg05729581 chr11:3078854 CARS 0.6 8.8 0.44 7.87e-17 Longevity; CRC cis rs4743820 0.651 rs10739912 chr9:93929115 A/G cg14446406 chr9:93919335 NA -0.76 -13.62 -0.6 8.32e-34 Ulcerative colitis;Inflammatory bowel disease; CRC cis rs1008375 1.000 rs56308330 chr4:17643050 G/A cg04450456 chr4:17643702 FAM184B 0.4 6.51 0.34 2.8e-10 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs2243480 1.000 rs13237037 chr7:65997882 T/C cg25985355 chr7:65971099 NA -0.52 -5.98 -0.31 5.68e-9 Diabetic kidney disease; CRC cis rs483180 0.512 rs677277 chr1:120202298 C/T cg19096424 chr1:120255104 PHGDH -0.43 -6.04 -0.32 4.12e-9 Macular telangiectasia type 2; CRC cis rs8031584 0.678 rs36047941 chr15:31159235 A/G cg14829155 chr15:31115871 NA -0.66 -10.21 -0.49 1.9e-21 Huntington's disease progression; CRC trans rs1814175 0.817 rs12287396 chr11:49819798 G/C cg03929089 chr4:120376271 NA -0.96 -18.34 -0.71 3.01e-52 Height; CRC cis rs12142240 0.698 rs56344958 chr1:46814518 G/A cg00530320 chr1:46809349 NSUN4 0.57 7.75 0.39 1.19e-13 Menopause (age at onset); CRC cis rs3733585 0.699 rs62294332 chr4:9959989 T/C cg00071950 chr4:10020882 SLC2A9 -0.54 -9.65 -0.47 1.42e-19 Cleft plate (environmental tobacco smoke interaction); CRC cis rs67478160 0.643 rs3742369 chr14:104251276 T/C cg01849466 chr14:104193079 ZFYVE21 -0.48 -8.31 -0.42 2.58e-15 Schizophrenia; CRC cis rs6860806 0.661 rs334902 chr5:131586559 C/G cg02033258 chr5:131593261 PDLIM4 0.41 7.78 0.39 9.25e-14 Breast cancer; CRC cis rs1799949 1.000 rs34534709 chr17:41302940 C/G cg25072359 chr17:41440525 NA 0.44 6.42 0.33 4.86e-10 Menopause (age at onset); CRC cis rs9311474 0.607 rs13076398 chr3:52573096 G/A cg08222913 chr3:52553049 STAB1 -0.37 -7.14 -0.37 6.08e-12 Electroencephalogram traits; CRC cis rs10992471 0.580 rs7030920 chr9:95122952 A/G cg14631576 chr9:95140430 CENPP -0.4 -7.12 -0.37 6.66e-12 Visceral adipose tissue/subcutaneous adipose tissue ratio; CRC cis rs1355223 0.583 rs2915238 chr11:34884405 C/A cg11058730 chr11:34937778 PDHX;APIP 0.74 12.06 0.55 5.41e-28 Systemic lupus erythematosus and Systemic sclerosis; CRC cis rs67340775 0.541 rs200975 chr6:27855625 G/T cg15845792 chr6:28175446 NA 0.85 8.72 0.43 1.38e-16 Lung cancer in ever smokers; CRC cis rs2204008 0.777 rs2387813 chr12:38382091 A/C cg26384229 chr12:38710491 ALG10B 0.68 9.75 0.47 6.92e-20 Bladder cancer; CRC cis rs1545257 0.514 rs2584940 chr2:24641639 A/C cg06627628 chr2:24431161 ITSN2 -0.43 -6.41 -0.33 5.05e-10 Sjögren's syndrome; CRC cis rs9399135 0.967 rs6909975 chr6:135315570 C/T cg24558204 chr6:135376177 HBS1L 0.49 7.55 0.38 4.23e-13 Red blood cell count; CRC cis rs910316 1.000 rs28626045 chr14:75589195 G/C cg11812906 chr14:75593930 NEK9 0.63 10.14 0.49 3.31e-21 Height; CRC trans rs11976180 0.569 rs12703565 chr7:143754401 C/T cg00397059 chr6:132031294 CTAGE9;ENPP3 -0.86 -9.43 -0.46 7.7e-19 Obesity-related traits; CRC cis rs12484776 0.786 rs17323591 chr22:40534211 T/A cg21771250 chr22:40406049 FAM83F 0.34 6.18 0.32 1.87e-9 Uterine fibroids; CRC cis rs6964587 0.626 rs12704631 chr7:91523525 T/C cg17063962 chr7:91808500 NA -0.58 -9.14 -0.45 6.77e-18 Breast cancer; CRC cis rs514406 0.893 rs522287 chr1:53365493 C/T cg24675658 chr1:53192096 ZYG11B -0.58 -8.46 -0.42 8.86e-16 Monocyte count; CRC cis rs3820068 0.581 rs111699992 chr1:15927158 G/A cg13390004 chr1:15929781 NA 0.51 7.2 0.37 4.22e-12 Systolic blood pressure; CRC cis rs79839061 0.610 rs11248051 chr4:858332 C/T cg07828340 chr4:882639 GAK 1.13 10.98 0.52 4.02e-24 Intelligence (multi-trait analysis); CRC cis rs9381040 0.610 rs4140579 chr6:41041752 G/A cg03644281 chr6:41068752 NFYA;LOC221442 -0.43 -6.01 -0.31 4.86e-9 Alzheimer's disease (late onset); CRC cis rs875971 0.540 rs4717275 chr7:65265180 C/T cg00343986 chr7:65444356 GUSB -0.57 -8.55 -0.43 4.8e-16 Aortic root size; CRC cis rs877282 0.733 rs7092976 chr10:756358 G/A cg17470449 chr10:769945 NA 0.61 7.96 0.4 2.78e-14 Uric acid levels; CRC cis rs9896933 0.830 rs607544 chr17:80768760 C/G cg20578329 chr17:80767326 TBCD -0.76 -9.45 -0.46 6.53e-19 Bone mineral accretion in asthma (oral corticosteroid dose interaction); CRC cis rs11997175 0.574 rs4389890 chr8:33658018 C/T ch.8.33884649F chr8:33765107 NA 0.51 8.22 0.41 4.77e-15 Body mass index; CRC cis rs2075671 0.903 rs62483570 chr7:100300649 C/T cg20848291 chr7:100343083 ZAN -0.69 -10.32 -0.49 8.04e-22 Other erythrocyte phenotypes; CRC cis rs9990333 0.687 rs62285383 chr3:195813923 T/G cg01351295 chr3:195700735 SDHAP1 -0.4 -5.65 -0.3 3.48e-8 Iron status biomarkers (transferrin levels);Iron status biomarkers (transferrin saturation); CRC cis rs9303401 0.659 rs17222691 chr17:56771096 C/T cg02118635 chr17:56770003 RAD51C;TEX14 0.81 9.93 0.48 1.65e-20 Cognitive test performance; CRC cis rs9814567 1.000 rs9850015 chr3:134269541 G/C cg06541857 chr3:134203789 ANAPC13;CEP63 -0.41 -6.27 -0.33 1.16e-9 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs9457247 1.000 rs448060 chr6:167382622 A/G cg23791538 chr6:167370224 RNASET2 -0.38 -5.97 -0.31 6.08e-9 Crohn's disease; CRC cis rs13108904 0.870 rs4974577 chr4:1266046 G/A cg05665937 chr4:1216051 CTBP1 0.41 5.91 0.31 8.46e-9 Obesity-related traits; CRC cis rs16924133 0.793 rs16923839 chr11:33142361 T/C cg05567920 chr11:33183001 CSTF3 -0.78 -5.92 -0.31 7.95e-9 Anger; CRC cis rs12200782 0.505 rs7765920 chr6:26514771 C/T cg09904177 chr6:26538194 HMGN4 0.55 6.57 0.34 1.95e-10 Small cell lung carcinoma; CRC cis rs4268898 0.679 rs2543666 chr2:24446042 C/T cg06627628 chr2:24431161 ITSN2 0.65 8.88 0.44 4.57e-17 Asthma; CRC cis rs2153535 0.580 rs1414340 chr6:8491139 G/A cg21535247 chr6:8435926 SLC35B3 0.5 7.54 0.38 4.72e-13 Motion sickness; CRC cis rs10089 0.953 rs10463839 chr5:127519675 T/A cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.67 8.62 0.43 2.77e-16 Ileal carcinoids; CRC cis rs11122272 0.735 rs2486729 chr1:231535584 C/T cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.57 -8.56 -0.43 4.51e-16 Hemoglobin concentration; CRC cis rs9814567 0.752 rs13075117 chr3:134329535 G/A cg06109529 chr3:134205091 CEP63;ANAPC13 0.68 9.82 0.48 3.92e-20 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC trans rs10982213 0.830 rs2274163 chr9:117188714 C/T cg23588161 chr11:65729143 SART1 0.39 5.98 0.31 5.77e-9 Interleukin-6 levels; CRC trans rs11165623 0.543 rs6656866 chr1:97002238 T/C cg10631902 chr5:14652156 NA -0.39 -6.62 -0.34 1.42e-10 Hip circumference;Waist circumference; CRC cis rs365302 1.000 rs374973 chr6:159645562 A/C cg14500486 chr6:159655392 FNDC1 0.43 6.6 0.34 1.68e-10 Coronary heart disease; CRC cis rs17270561 0.666 rs1937129 chr6:25789132 A/G cg16482183 chr6:26056742 HIST1H1C 0.71 9.29 0.46 2.11e-18 Iron status biomarkers; CRC cis rs2836974 0.932 rs11910151 chr21:40560262 T/C cg11644478 chr21:40555479 PSMG1 0.83 13.31 0.59 1.29e-32 Cognitive function; CRC cis rs7584330 0.744 rs58223447 chr2:238378644 G/C cg16989719 chr2:238392110 NA -0.44 -7.56 -0.38 4.12e-13 Prostate cancer; CRC cis rs8044868 0.530 rs7201866 chr16:72086534 A/T cg23815491 chr16:72088622 HP 0.47 6.63 0.34 1.39e-10 Body mass index (change over time) in cancer or chronic obstructive pulmonary disease;Body mass index (change over time) in cancer; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg06467769 chr19:37808668 NA 0.36 5.99 0.31 5.65e-9 Liver disease severity in Alagille syndrome; CRC cis rs4713118 0.911 rs9461406 chr6:27719764 C/T cg15845792 chr6:28175446 NA -0.64 -7.78 -0.39 9.73e-14 Parkinson's disease; CRC cis rs10751667 0.600 rs11246376 chr11:999622 C/T cg23136738 chr11:925521 AP2A2 -0.4 -6.12 -0.32 2.62e-9 Alzheimer's disease (late onset); CRC cis rs12476592 0.543 rs1900303 chr2:63897260 C/T cg10828910 chr2:63850056 LOC388955 0.5 6.26 0.33 1.23e-9 Childhood ear infection; CRC cis rs2077654 0.556 rs2299640 chr11:17441228 A/G cg25308976 chr11:17434268 ABCC8 0.62 6.85 0.35 3.74e-11 Gout; CRC cis rs1568889 1.000 rs12794100 chr11:28332785 A/T cg06544937 chr11:28130018 METT5D1;KIF18A 0.79 10.95 0.52 5.53e-24 Bipolar disorder; CRC cis rs950169 1.000 rs950169 chr15:84706461 C/T cg11189052 chr15:85197271 WDR73 0.61 8.85 0.44 5.62e-17 Schizophrenia; CRC cis rs11608355 0.515 rs56244055 chr12:109936211 G/A cg05360138 chr12:110035743 NA 0.76 8.5 0.42 6.78e-16 Neuroticism; CRC cis rs568617 0.768 rs12225345 chr11:65647105 A/G cg26695010 chr11:65641043 EFEMP2 -0.54 -5.67 -0.3 3.13e-8 Crohn's disease; CRC cis rs6460942 0.908 rs112049544 chr7:12242551 A/G cg06484146 chr7:12443880 VWDE -0.68 -6.58 -0.34 1.82e-10 Coronary artery disease; CRC cis rs2228479 0.850 rs17226498 chr16:89840631 T/C cg06656553 chr16:89960601 TCF25 -0.71 -5.96 -0.31 6.42e-9 Skin colour saturation; CRC cis rs10788264 0.504 rs7069328 chr10:124030741 G/C cg09507567 chr10:124027408 NA 0.37 8.17 0.41 6.71e-15 Total body bone mineral density; CRC cis rs7178572 0.524 rs1473922 chr15:77656798 G/T cg22256960 chr15:77711686 NA -0.64 -9.4 -0.46 9.62e-19 Type 2 diabetes; CRC cis rs8062405 0.755 rs2077031 chr16:28603168 T/A cg16576597 chr16:28551801 NUPR1 0.55 8.06 0.41 1.39e-14 Cognitive ability (multi-trait analysis);Cognitive ability; CRC cis rs4268898 0.722 rs11691212 chr2:24404733 A/G cg06627628 chr2:24431161 ITSN2 0.46 6.75 0.35 6.52e-11 Asthma; CRC trans rs6951245 1.000 rs78158942 chr7:1090440 G/T cg13565492 chr6:43139072 SRF -0.7 -7.11 -0.36 7.37e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs881375 0.967 rs1008382 chr9:123681255 C/G cg09419670 chr9:123605666 PSMD5;LOC253039 0.59 8.83 0.44 6.2e-17 Rheumatoid arthritis; CRC cis rs919433 1.000 rs1429414 chr2:198162430 C/T cg20885578 chr2:198174922 NA -0.37 -6.43 -0.33 4.61e-10 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC cis rs9322817 0.691 rs4946648 chr6:105329422 G/T cg02098413 chr6:105308735 HACE1 0.43 8.49 0.42 7.27e-16 Thyroid stimulating hormone; CRC cis rs1545257 0.537 rs2249387 chr2:24649801 C/G cg06627628 chr2:24431161 ITSN2 0.45 6.63 0.34 1.37e-10 Sjögren's syndrome; CRC cis rs853679 1.000 rs2799079 chr6:28235176 A/C cg03623178 chr6:28175578 NA 0.68 7.32 0.37 1.98e-12 Depression; CRC cis rs1552244 0.882 rs13063098 chr3:10009919 G/A cg16606324 chr3:10149918 C3orf24 0.64 8.37 0.42 1.67e-15 Alzheimer's disease; CRC cis rs1816752 0.870 rs9581025 chr13:24997825 T/C cg02811702 chr13:24901961 NA 0.43 5.97 0.31 5.99e-9 Obesity-related traits; CRC cis rs7107174 0.901 rs4945275 chr11:78119822 G/A cg02023728 chr11:77925099 USP35 0.4 7.14 0.37 5.98e-12 Testicular germ cell tumor; CRC cis rs1552244 0.882 rs68080705 chr3:10025743 C/T cg00166722 chr3:10149974 C3orf24 0.59 7.68 0.39 1.87e-13 Alzheimer's disease; CRC cis rs11190604 1.000 rs7071271 chr10:102264824 G/A cg16342193 chr10:102329863 NA -0.37 -6.12 -0.32 2.69e-9 Palmitoleic acid (16:1n-7) levels; CRC cis rs7493 1.000 rs2040993 chr7:95047300 T/A cg21856205 chr7:94953877 PON1 -0.48 -6.28 -0.33 1.1e-9 Yu-Zhi constitution type in type 2 diabetes; CRC trans rs1814175 0.541 rs12287397 chr11:49819799 G/A cg15704280 chr7:45808275 SEPT13 -0.97 -18.71 -0.72 1.05e-53 Height; CRC trans rs11148252 0.819 rs7336679 chr13:53043333 G/A cg18335740 chr13:41363409 SLC25A15 0.54 8.25 0.41 3.96e-15 Lewy body disease; CRC cis rs2153535 0.580 rs2327062 chr6:8453858 G/A cg21535247 chr6:8435926 SLC35B3 0.5 7.46 0.38 7.85e-13 Motion sickness; CRC trans rs56176327 0.532 rs9849038 chr3:49771990 A/G cg21665057 chr3:196295764 WDR53;FBXO45 -0.61 -6.87 -0.35 3.25e-11 Intelligence (multi-trait analysis); CRC trans rs66759488 0.739 rs10851451 chr15:47608991 A/G cg18950002 chr17:79673969 MRPL12 -0.48 -6.64 -0.34 1.33e-10 Lung cancer; CRC cis rs4474465 0.646 rs4945301 chr11:78283362 A/G cg27205649 chr11:78285834 NARS2 0.53 6.85 0.35 3.63e-11 Alzheimer's disease (survival time); CRC cis rs6860806 0.507 rs270608 chr5:131648406 C/T cg09877947 chr5:131593287 PDLIM4 0.47 7.62 0.39 2.72e-13 Breast cancer; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg08424427 chr5:180670815 SNORD95;GNB2L1 0.39 6.52 0.34 2.64e-10 Liver disease severity in Alagille syndrome; CRC cis rs6582630 0.512 rs11182667 chr12:38588392 C/A cg13010199 chr12:38710504 ALG10B -0.43 -6.23 -0.32 1.4e-9 Drug-induced liver injury (flucloxacillin); CRC cis rs6831352 1.000 rs6822348 chr4:100053894 A/T cg13256891 chr4:100009986 ADH5 0.6 8.44 0.42 1.05e-15 Alcohol dependence; CRC cis rs7918232 0.941 rs10741128 chr10:27411509 G/A cg14240646 chr10:27532245 ACBD5 -0.85 -9.81 -0.48 4.13e-20 Breast cancer; CRC cis rs9733 0.596 rs1415148 chr1:150705755 G/A cg18016565 chr1:150552671 MCL1 0.44 6.3 0.33 9.53e-10 Tonsillectomy; CRC cis rs13336428 0.730 rs3946124 chr16:1525779 A/G cg08008072 chr16:1524255 CLCN7 0.67 13.38 0.59 6.78e-33 Bone mineral density; CRC cis rs13031619 0.517 rs10183413 chr2:3684342 T/C cg01268866 chr2:3683757 COLEC11 -0.58 -8.12 -0.41 9.51e-15 Response to inhaled corticosteroid treatment in asthma (change in FEV1); CRC cis rs951366 0.646 rs1772159 chr1:205759195 G/A cg24739457 chr1:205821442 NA 0.42 5.89 0.31 9.53e-9 Menarche (age at onset); CRC trans rs7507204 0.530 rs4807469 chr19:3443382 G/C cg08382705 chr11:45687319 CHST1 -0.43 -7.96 -0.4 2.91e-14 Height; CRC cis rs6582630 0.537 rs11611326 chr12:38547958 C/A cg26384229 chr12:38710491 ALG10B 0.72 9.66 0.47 1.31e-19 Drug-induced liver injury (flucloxacillin); CRC cis rs10512697 1.000 rs34988275 chr5:3549238 C/T cg19473799 chr5:3511975 NA -0.72 -5.66 -0.3 3.22e-8 Immune response to smallpox vaccine (IL-6); CRC cis rs17376456 0.825 rs34967135 chr5:93221785 G/A cg21475434 chr5:93447410 FAM172A 0.75 7.47 0.38 7.27e-13 Diabetic retinopathy; CRC cis rs12936587 0.601 rs8068296 chr17:17554563 A/C cg04398451 chr17:18023971 MYO15A 0.36 6.05 0.32 3.93e-9 Hip circumference;Coronary artery disease or large artery stroke;Coronary heart disease;Coronary artery disease; CRC cis rs4819052 0.851 rs9974891 chr21:46680767 T/A cg19498844 chr21:46707878 POFUT2;LOC642852 0.7 10.15 0.49 3.01e-21 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs10256972 0.684 rs2363279 chr7:1096143 A/G cg18402987 chr7:1209562 NA 0.44 6.56 0.34 2.07e-10 Longevity;Endometriosis; CRC cis rs7799006 0.782 rs2159044 chr7:2262941 C/A cg08027265 chr7:2291960 NA -0.34 -5.74 -0.3 2.1e-8 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs9381040 0.610 rs9394758 chr6:41017821 C/T cg09580153 chr6:41068724 NFYA;LOC221442 -0.42 -6.17 -0.32 1.96e-9 Alzheimer's disease (late onset); CRC trans rs12495832 0.778 rs12633861 chr3:147919557 C/T cg10221266 chr7:153579447 NA 0.56 6.13 0.32 2.54e-9 Chin dimples; CRC cis rs12188164 0.965 rs72717430 chr5:444502 T/C cg17553881 chr5:443987 EXOC3;C5orf55 -0.37 -7.81 -0.4 7.64e-14 Cystic fibrosis severity; CRC cis rs6714710 0.603 rs11684749 chr2:98420142 G/C cg26665480 chr2:98280029 ACTR1B 0.52 7.18 0.37 4.53e-12 Posterior cortical atrophy and Alzheimer's disease; CRC cis rs2895526 0.580 rs11257930 chr10:12696120 A/G cg00115178 chr10:12648176 CAMK1D 0.36 5.91 0.31 8.66e-9 Headache; CRC cis rs7659604 1.000 rs6816071 chr4:122665185 G/A cg20573242 chr4:122745356 CCNA2 0.42 6.27 0.33 1.12e-9 Type 2 diabetes; CRC cis rs79387448 0.745 rs59694233 chr2:103116521 G/A cg09003973 chr2:102972529 NA 0.68 7.54 0.38 4.74e-13 Gut microbiota (bacterial taxa); CRC trans rs2303319 0.504 rs35304298 chr2:162617185 G/T cg22627826 chr19:1240265 ATP5D -0.72 -6.24 -0.33 1.37e-9 Cognitive function; CRC cis rs1799949 1.000 rs4793197 chr17:41231902 C/T cg19454999 chr17:41278357 BRCA1;NBR2 0.55 8.46 0.42 9.06e-16 Menopause (age at onset); CRC cis rs59104589 0.920 rs59916403 chr2:242370751 G/T cg10021735 chr2:242295487 FARP2 0.47 6.58 0.34 1.89e-10 Fibrinogen levels; CRC cis rs11098499 0.754 rs878376 chr4:120237702 G/A cg09307838 chr4:120376055 NA 0.61 9.61 0.47 1.93e-19 Corneal astigmatism; CRC cis rs6500602 0.592 rs7206782 chr16:4515145 A/C cg14951292 chr16:4525986 HMOX2;NMRAL1 0.61 8.45 0.42 9.86e-16 Schizophrenia; CRC cis rs344364 0.511 rs911391 chr16:1947016 C/A cg03013636 chr16:1946785 NA 0.59 7.18 0.37 4.7e-12 Glomerular filtration rate in chronic kidney disease; CRC cis rs7264396 1.000 rs6088881 chr20:34165609 C/T cg04508476 chr20:34239394 CPNE1;RBM12 0.45 7.54 0.38 4.51e-13 Total cholesterol levels; CRC cis rs1865760 0.827 rs9295681 chr6:25944117 T/G cg16482183 chr6:26056742 HIST1H1C 0.51 7.34 0.37 1.72e-12 Height; CRC cis rs6960043 0.782 rs10228456 chr7:15063926 C/T cg19272540 chr7:15055459 NA -0.22 -5.89 -0.31 9.29e-9 Type 2 diabetes; CRC trans rs7267979 1.000 rs4815407 chr20:25341478 G/C cg17903999 chr18:56338584 MALT1 0.41 6.83 0.35 4.19e-11 Liver enzyme levels (alkaline phosphatase); CRC cis rs1465370 0.760 rs10263705 chr7:130027633 C/T cg03229158 chr7:130009420 NA -0.46 -6.66 -0.34 1.14e-10 Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction);Waist circumference adjusted for BMI in active individuals;Waist circumference adjusted for body mass index; CRC cis rs4237845 0.611 rs4272820 chr12:58330541 G/A cg00677455 chr12:58241039 CTDSP2 0.4 5.71 0.3 2.51e-8 Intelligence (multi-trait analysis); CRC cis rs10504229 0.679 rs56040464 chr8:58131603 G/A cg24829409 chr8:58192753 C8orf71 -0.55 -8.03 -0.4 1.71e-14 Developmental language disorder (linguistic errors); CRC trans rs877282 1.000 rs11253370 chr10:773712 G/A cg22713356 chr15:30763199 NA 1.14 14.67 0.63 7.68e-38 Uric acid levels; CRC cis rs1949733 1.000 rs3103072 chr4:8508431 C/T cg11789530 chr4:8429930 ACOX3 -0.87 -12.88 -0.58 5.33e-31 Response to antineoplastic agents; CRC cis rs9549260 0.755 rs2721067 chr13:41156708 C/T cg21288729 chr13:41239152 FOXO1 0.38 5.84 0.31 1.25e-8 Red blood cell count; CRC cis rs938554 0.735 rs11942223 chr4:9962765 T/C cg11266682 chr4:10021025 SLC2A9 -0.36 -5.63 -0.3 3.82e-8 Blood metabolite levels; CRC cis rs9549367 0.707 rs9549353 chr13:113843427 G/A cg00898013 chr13:113819073 PROZ -0.57 -8.03 -0.41 1.69e-14 Platelet distribution width; CRC cis rs4148883 0.651 rs4147547 chr4:100127311 G/T cg12011299 chr4:100065546 ADH4 0.5 10.92 0.52 6.7e-24 Alcohol dependence; CRC cis rs6502050 0.835 rs7502078 chr17:80131879 C/A cg25804541 chr17:80189381 SLC16A3 -0.3 -5.85 -0.31 1.17e-8 Life satisfaction; CRC cis rs3733585 0.746 rs4318650 chr4:10016868 T/C cg00071950 chr4:10020882 SLC2A9 0.62 11.19 0.53 7.45e-25 Cleft plate (environmental tobacco smoke interaction); CRC cis rs4555082 0.834 rs2816631 chr14:105739477 G/A cg10792982 chr14:105748885 BRF1 0.35 5.67 0.3 3.08e-8 Mean platelet volume;Platelet distribution width; CRC cis rs3785574 0.962 rs7219920 chr17:61811642 C/G cg22520471 chr17:61851767 DDX42;CCDC47 0.44 6.13 0.32 2.55e-9 Height; CRC cis rs5769765 0.862 rs9616392 chr22:50314705 G/A cg26441486 chr22:50317300 CRELD2 0.32 5.61 0.3 4.31e-8 Schizophrenia; CRC trans rs116095464 0.558 rs7356561 chr5:284381 G/C cg00938859 chr5:1591904 SDHAP3 0.71 7.58 0.39 3.45e-13 Breast cancer; CRC cis rs2294693 0.947 rs10155663 chr6:40994301 T/G cg14769373 chr6:40998127 UNC5CL -0.5 -6.76 -0.35 6.15e-11 Gastric cancer;Non-cardia gastric cancer; CRC cis rs56313388 0.751 rs8057553 chr16:56334990 A/G cg02433656 chr16:56322654 GNAO1 0.52 7.84 0.4 6.43e-14 Pulse pressure; CRC cis rs2565722 0.609 rs9365227 chr6:161297925 G/T cg03159191 chr6:161285451 NA -0.46 -6.4 -0.33 5.47e-10 Blood protein levels; CRC cis rs62103177 0.810 rs62103188 chr18:77627661 G/A cg12964065 chr18:77638022 KCNG2 0.66 6.69 0.35 9.58e-11 Opioid sensitivity; CRC cis rs67311347 1.000 rs1466237 chr3:40462026 C/G cg24209194 chr3:40518798 ZNF619 0.42 6.36 0.33 6.56e-10 Renal cell carcinoma; CRC trans rs8002861 0.765 rs12868462 chr13:44453480 C/T cg12856521 chr11:46389249 DGKZ -0.43 -6.78 -0.35 5.53e-11 Leprosy; CRC cis rs6460942 1.000 rs62448565 chr7:12400458 G/A cg06484146 chr7:12443880 VWDE -0.76 -7.53 -0.38 4.86e-13 Coronary artery disease; CRC cis rs1448094 0.842 rs10779231 chr12:86462237 T/C cg18827107 chr12:86230957 RASSF9 0.36 5.69 0.3 2.79e-8 Major depressive disorder; CRC cis rs2302190 0.882 rs3803751 chr17:56650356 A/G cg25885038 chr17:56607967 SEPT4 -0.51 -7.61 -0.39 2.96e-13 Vitamin D levels; CRC trans rs587242 1.000 rs1830868 chr1:96895906 G/A cg10631902 chr5:14652156 NA 0.44 6.81 0.35 4.51e-11 Body mass index (joint analysis main effects and physical activity interaction);Body mass index in physically inactive individuals;Body mass index; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg13784889 chr4:89513377 HERC3 0.46 6.64 0.34 1.26e-10 Response to antipsychotic treatment; CRC cis rs1865760 0.516 rs9393683 chr6:26066198 A/G cg16482183 chr6:26056742 HIST1H1C 0.51 7.39 0.38 1.24e-12 Height; CRC cis rs1018836 0.923 rs2105965 chr8:91537690 T/C cg16814680 chr8:91681699 NA -0.76 -12.32 -0.56 6.03e-29 Ejection fraction in Tripanosoma cruzi seropositivity; CRC cis rs875971 0.798 rs6460304 chr7:65964728 G/A cg11764359 chr7:65958608 NA 0.61 9.57 0.47 2.61e-19 Aortic root size; CRC cis rs2576037 0.583 rs9304336 chr18:44461687 T/C cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.57 -8.88 -0.44 4.47e-17 Personality dimensions; CRC cis rs11608355 0.515 rs34038572 chr12:109901657 A/G cg05360138 chr12:110035743 NA 0.77 8.7 0.43 1.65e-16 Neuroticism; CRC cis rs7811142 0.830 rs7792525 chr7:99972122 A/G cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.6 7.74 0.39 1.26e-13 Platelet count; CRC cis rs4718428 0.672 rs36038499 chr7:66289615 A/G cg18252515 chr7:66147081 NA -0.54 -7.48 -0.38 6.94e-13 Corneal structure; CRC cis rs12760731 0.582 rs35302804 chr1:178513342 G/A cg00404053 chr1:178313656 RASAL2 0.71 7.82 0.4 7.09e-14 Obesity-related traits; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg04886448 chr17:27224035 FLOT2 0.41 5.98 0.31 5.81e-9 Liver disease severity in Alagille syndrome; CRC cis rs1050631 0.564 rs1785934 chr18:33718326 A/C cg25426722 chr18:33708991 SLC39A6;ELP2 0.37 5.69 0.3 2.8e-8 Esophageal squamous cell cancer (length of survival); CRC cis rs6665290 0.935 rs1929862 chr1:227199718 G/A cg10327440 chr1:227177885 CDC42BPA -1.01 -21.75 -0.77 1.22e-65 Myeloid white cell count; CRC cis rs3785574 0.962 rs7215915 chr17:61828385 C/T cg06601766 chr17:61851465 DDX42;CCDC47 0.58 8.34 0.42 2.13e-15 Height; CRC cis rs35306767 0.904 rs10904584 chr10:983747 A/T cg20503657 chr10:835505 NA 0.77 9.75 0.47 6.59e-20 Eosinophil percentage of granulocytes; CRC cis rs11212617 1.000 rs600931 chr11:108117335 C/T cg12106634 chr11:108092400 ATM;NPAT 0.43 6.26 0.33 1.22e-9 Response to metformin in type 2 diabetes (glycemic); CRC cis rs3790844 0.667 rs3790843 chr1:200010824 A/G cg07208853 chr1:200005219 NR5A2 -0.34 -8.67 -0.43 2.06e-16 Pancreatic cancer; CRC cis rs9341808 0.667 rs2490251 chr6:80895164 A/G cg08355045 chr6:80787529 NA 0.33 5.65 0.3 3.52e-8 Sitting height ratio; CRC cis rs853679 0.517 rs35512245 chr6:28079953 T/C cg02631126 chr6:28058918 ZSCAN12L1 0.29 5.88 0.31 1.01e-8 Depression; CRC cis rs860295 0.702 rs12067371 chr1:155437669 C/T cg02153340 chr1:155202674 NA -0.53 -6.97 -0.36 1.73e-11 Body mass index; CRC cis rs6831352 0.918 rs2851251 chr4:100044111 A/G cg13256891 chr4:100009986 ADH5 0.65 8.7 0.43 1.65e-16 Alcohol dependence; CRC cis rs7618915 0.501 rs35526119 chr3:52749334 C/T cg05573699 chr3:52720067 GNL3;PBRM1 -0.48 -6.95 -0.36 2.01e-11 Bipolar disorder; CRC trans rs1005277 0.563 rs2800550 chr10:38482929 T/C cg27523141 chr10:43048294 ZNF37B 0.47 6.74 0.35 7.02e-11 Extrinsic epigenetic age acceleration; CRC cis rs6540559 1.000 rs4844895 chr1:209958580 T/C cg23283495 chr1:209979779 IRF6 0.45 6.89 0.35 2.9e-11 Cleft lip with or without cleft palate; CRC cis rs12325245 0.536 rs71389028 chr16:58663260 G/A cg02549819 chr16:58548995 SETD6 1.2 7.97 0.4 2.72e-14 Schizophrenia; CRC cis rs9322817 0.583 rs10782363 chr6:105149713 C/G cg02098413 chr6:105308735 HACE1 0.43 8.51 0.42 6.15e-16 Thyroid stimulating hormone; CRC cis rs514406 0.505 rs269292 chr1:53187911 T/C cg27535305 chr1:53392650 SCP2 -0.34 -6.08 -0.32 3.26e-9 Monocyte count; CRC cis rs6502050 0.637 rs74765203 chr17:80118223 A/G cg25804541 chr17:80189381 SLC16A3 -0.32 -6.1 -0.32 2.93e-9 Life satisfaction; CRC cis rs28386778 0.831 rs2584618 chr17:61923611 T/C cg23090583 chr17:61904693 PSMC5;FTSJ3 1.04 19.76 0.74 7.57e-58 Prudent dietary pattern; CRC cis rs9311474 0.508 rs6805156 chr3:52609362 T/C cg05573699 chr3:52720067 GNL3;PBRM1 -0.47 -6.96 -0.36 1.9e-11 Electroencephalogram traits; CRC trans rs10504229 0.953 rs78089850 chr8:58171557 A/G cg04077850 chr5:125800366 GRAMD3 0.38 6.2 0.32 1.73e-9 Developmental language disorder (linguistic errors); CRC cis rs17021463 0.872 rs34181160 chr4:95275157 T/G cg11021082 chr4:95130006 SMARCAD1 0.48 7.21 0.37 3.85e-12 Testicular germ cell tumor; CRC cis rs4665809 0.590 rs1368902 chr2:26440576 T/C cg26119090 chr2:26468346 HADHA;HADHB -1.06 -15.5 -0.65 4.69e-41 Gut microbiome composition (summer); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg10446143 chr21:44394730 PKNOX1 0.48 6.83 0.35 4.17e-11 Response to antipsychotic treatment; CRC cis rs28386778 0.701 rs2727337 chr17:61991966 G/A cg25654072 chr17:61904446 PSMC5;FTSJ3 -0.6 -8.98 -0.44 2.18e-17 Prudent dietary pattern; CRC cis rs9522267 0.535 rs2039916 chr13:112238863 A/C cg26182253 chr13:112236782 NA 0.31 6.24 0.33 1.35e-9 Hepatitis; CRC trans rs8073060 0.544 rs225268 chr17:33966224 A/C cg19694781 chr19:47549865 TMEM160 -1.05 -14.7 -0.63 5.76e-38 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; CRC cis rs4713118 0.516 rs4713142 chr6:28106347 T/G cg02683197 chr6:28174875 NA 0.85 10.52 0.5 1.71e-22 Parkinson's disease; CRC cis rs61008539 0.893 rs4721502 chr7:862186 A/G cg00475322 chr7:917719 C7orf20 0.43 7.7 0.39 1.56e-13 Perceived unattractiveness to mosquitoes; CRC cis rs2645694 0.603 rs2703123 chr4:77821154 C/T cg18351406 chr4:77819688 ANKRD56 0.5 7.53 0.38 5e-13 Emphysema distribution in smoking; CRC cis rs875971 0.862 rs7783779 chr7:65796626 A/G cg18876405 chr7:65276391 NA -0.54 -8.57 -0.43 4.1e-16 Aortic root size; CRC trans rs28735056 0.509 rs4799094 chr18:77621727 T/C cg08586216 chr6:35612351 FKBP5 0.4 6.22 0.32 1.52e-9 Schizophrenia; CRC cis rs7223966 0.883 rs2955250 chr17:61959740 C/T cg23903597 chr17:61704154 MAP3K3 -0.44 -6.0 -0.31 5.31e-9 Hip circumference adjusted for BMI;Body mass index; CRC cis rs7615952 0.641 rs12491577 chr3:125731131 C/T cg06494592 chr3:125709126 NA -0.54 -6.42 -0.33 4.71e-10 Blood pressure (smoking interaction); CRC cis rs2952156 0.920 rs14050 chr17:37828072 C/T cg20243544 chr17:37824526 PNMT 0.58 9.05 0.45 1.28e-17 Asthma; CRC cis rs2952156 0.920 rs907090 chr17:37833632 T/C cg20243544 chr17:37824526 PNMT 0.55 8.95 0.44 2.66e-17 Asthma; CRC trans rs2303319 0.504 rs12470743 chr2:162611202 G/A cg13490827 chr1:46269305 MAST2 -0.69 -6.0 -0.31 5.24e-9 Cognitive function; CRC cis rs7107174 1.000 rs72931639 chr11:78036703 C/T cg02023728 chr11:77925099 USP35 0.48 7.33 0.37 1.79e-12 Testicular germ cell tumor; CRC cis rs3820068 0.554 rs60233444 chr1:15921330 A/C cg24675056 chr1:15929824 NA 0.47 6.24 0.33 1.33e-9 Systolic blood pressure; CRC cis rs10512697 0.655 rs13156164 chr5:3509083 C/T cg19473799 chr5:3511975 NA -0.83 -6.35 -0.33 7.32e-10 Immune response to smallpox vaccine (IL-6); CRC cis rs449789 0.857 rs578714 chr6:159715118 G/T cg14500486 chr6:159655392 FNDC1 -0.48 -7.29 -0.37 2.38e-12 Pulse pressure; CRC trans rs9858542 1.000 rs11718165 chr3:49696797 A/G cg21582582 chr3:182698605 DCUN1D1 -0.56 -6.87 -0.35 3.31e-11 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs1552244 0.935 rs11926481 chr3:10142102 G/T cg08888203 chr3:10149979 C3orf24 0.69 9.78 0.47 5.55e-20 Alzheimer's disease; CRC cis rs6543140 0.964 rs6734203 chr2:103080066 G/C cg04239558 chr2:103089729 SLC9A4 0.37 6.59 0.34 1.72e-10 Blood protein levels; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg16565161 chr1:155292726 RUSC1;C1orf104 0.42 6.06 0.32 3.78e-9 Intelligence (multi-trait analysis); CRC cis rs1008375 0.931 rs2098151 chr4:17577490 T/C cg16339924 chr4:17578868 LAP3 0.6 7.94 0.4 3.25e-14 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs853679 0.517 rs9368553 chr6:28082265 T/C cg12273811 chr6:28175739 NA 0.73 9.18 0.45 4.85e-18 Depression; CRC cis rs10479542 0.784 rs7702303 chr5:178986436 G/A cg09060608 chr5:178986726 RUFY1 0.55 9.68 0.47 1.19e-19 Lung cancer; CRC cis rs11212617 0.935 rs1607476 chr11:108075161 A/C cg01991180 chr11:108092276 ATM;NPAT 0.41 6.03 0.32 4.37e-9 Response to metformin in type 2 diabetes (glycemic); CRC cis rs6860806 0.695 rs6867282 chr5:131583120 G/C cg18301423 chr5:131593218 PDLIM4 0.37 6.87 0.35 3.16e-11 Breast cancer; CRC trans rs11098499 0.955 rs7684942 chr4:120162201 C/T cg25214090 chr10:38739885 LOC399744 0.52 8.02 0.4 1.94e-14 Corneal astigmatism; CRC cis rs10504229 0.683 rs66893068 chr8:58144238 A/G cg02290350 chr8:58132656 NA -0.58 -8.21 -0.41 5.01e-15 Developmental language disorder (linguistic errors); CRC cis rs4713118 0.513 rs149897 chr6:28006650 A/G cg20615401 chr6:28092323 ZSCAN16 0.46 6.23 0.32 1.45e-9 Parkinson's disease; CRC cis rs6988985 0.765 rs7011830 chr8:143982392 G/T cg10324643 chr8:143916377 GML -0.37 -6.15 -0.32 2.25e-9 Plasma androstenedione levels in resected early stage-receptor positive breast cancer; CRC cis rs769267 0.929 rs2905424 chr19:19473445 T/C cg01262667 chr19:19385393 TM6SF2 -0.37 -5.99 -0.31 5.56e-9 Tonsillectomy; CRC trans rs7618501 0.601 rs2624825 chr3:50154989 G/A cg21659725 chr3:3221576 CRBN -0.55 -8.77 -0.44 9.89e-17 Intelligence (multi-trait analysis); CRC cis rs1865760 0.865 rs9467647 chr6:25957642 A/G cg16482183 chr6:26056742 HIST1H1C 0.55 8.06 0.41 1.44e-14 Height; CRC cis rs2197308 0.667 rs11181073 chr12:37898543 A/G cg13010199 chr12:38710504 ALG10B 0.45 6.0 0.31 5.12e-9 Morning vs. evening chronotype; CRC cis rs780096 0.546 rs4665976 chr2:27640325 A/G cg27432699 chr2:27873401 GPN1 -0.5 -7.77 -0.39 1.02e-13 Total body bone mineral density; CRC cis rs6570726 0.846 rs446031 chr6:145885592 C/T cg23711669 chr6:146136114 FBXO30 0.67 11.2 0.53 7.19e-25 Lobe attachment (rater-scored or self-reported); CRC cis rs8060686 0.565 rs36046686 chr16:68122269 T/C cg08314208 chr16:67682810 RLTPR -0.55 -5.96 -0.31 6.57e-9 HDL cholesterol;Metabolic syndrome; CRC cis rs35146811 0.735 rs1043915 chr7:99799845 T/A cg00553149 chr7:99775558 STAG3;GPC2 0.24 5.62 0.3 4.14e-8 Coronary artery disease; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg04219625 chr11:66247798 DPP3 0.45 6.0 0.31 5.08e-9 Anxiety disorder; CRC trans rs6539288 0.803 rs10778517 chr12:107341664 G/T cg02152992 chr13:48877591 RB1 -0.43 -6.11 -0.32 2.89e-9 Total body bone mineral density; CRC cis rs13108904 0.967 rs4974582 chr4:1279687 C/T cg19318889 chr4:1322082 MAEA 0.4 5.71 0.3 2.57e-8 Obesity-related traits; CRC cis rs6545883 0.894 rs2177962 chr2:61588070 T/A cg15711740 chr2:61764176 XPO1 0.43 5.68 0.3 2.92e-8 Tuberculosis; CRC cis rs12142240 0.698 rs72890727 chr1:46860237 G/A cg14993813 chr1:46806288 NSUN4 -0.48 -6.03 -0.32 4.47e-9 Menopause (age at onset); CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg03437924 chr16:25123326 LCMT1 0.39 6.16 0.32 2.18e-9 Obesity-related traits; CRC cis rs35146811 0.807 rs10228764 chr7:99608029 A/G cg13334819 chr7:99746414 C7orf59 -0.56 -7.61 -0.39 2.85e-13 Coronary artery disease; CRC cis rs6961069 0.806 rs1761665 chr7:80242079 A/G cg04458919 chr7:80252533 CD36 -0.35 -6.34 -0.33 7.45e-10 Platelet count; CRC cis rs2032447 0.507 rs199741 chr6:25931577 A/G cg26028573 chr6:26043587 HIST1H2BB 0.43 5.67 0.3 3.12e-8 Intelligence (multi-trait analysis); CRC cis rs2985684 0.901 rs7146248 chr14:50112067 C/T cg04989706 chr14:50066350 PPIL5 -0.56 -7.71 -0.39 1.48e-13 Carotid intima media thickness; CRC cis rs1799949 0.628 rs4474733 chr17:41433660 G/T cg23758822 chr17:41437982 NA 0.76 11.19 0.52 7.79e-25 Menopause (age at onset); CRC cis rs568617 0.768 rs12225345 chr11:65647105 A/G cg19792802 chr11:65647270 CTSW 0.61 7.34 0.38 1.66e-12 Crohn's disease; CRC cis rs11252926 0.537 rs4881274 chr10:459940 G/A cg16386425 chr10:429943 DIP2C -0.44 -6.73 -0.35 7.45e-11 Psychosis in Alzheimer's disease; CRC cis rs6089584 0.816 rs744778 chr20:60631365 A/G cg23262073 chr20:60523788 NA -0.48 -7.6 -0.39 3.15e-13 Body mass index; CRC cis rs34779708 0.931 rs4934693 chr10:35271844 G/A cg03585969 chr10:35415529 CREM 0.66 8.76 0.43 1.09e-16 Inflammatory bowel disease;Crohn's disease; CRC cis rs10463316 0.928 rs10060441 chr5:150750006 A/G cg03212797 chr5:150827313 SLC36A1 -0.51 -8.08 -0.41 1.26e-14 Metabolite levels (Pyroglutamine); CRC cis rs10256972 0.552 rs7805591 chr7:1210745 A/G cg07308232 chr7:1071921 C7orf50 -0.44 -6.02 -0.32 4.57e-9 Longevity;Endometriosis; CRC cis rs78456975 0.739 rs11891867 chr2:1517894 C/T cg26248373 chr2:1572462 NA -0.68 -8.52 -0.43 5.83e-16 Placebo response in major depressive disorder (% change in symptom score); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg03804568 chr22:39548919 CBX7 0.41 6.06 0.32 3.68e-9 Intelligence (multi-trait analysis); CRC cis rs561341 0.941 rs501773 chr17:30314435 T/G cg12193833 chr17:30244370 NA -0.62 -8.01 -0.4 2e-14 Hip circumference adjusted for BMI; CRC cis rs76878669 0.561 rs3177514 chr11:66130358 T/G cg24851651 chr11:66362959 CCS -0.37 -6.41 -0.33 5.18e-10 Educational attainment (years of education); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg01086389 chr3:150321178 SELT 0.42 6.02 0.31 4.68e-9 Intelligence (multi-trait analysis); CRC cis rs9747201 0.890 rs12946944 chr17:80061748 C/T cg09264619 chr17:80180166 NA 0.52 7.28 0.37 2.55e-12 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs9303401 0.659 rs12946397 chr17:56769979 C/T cg10487724 chr17:56770010 TEX14;RAD51C 0.79 10.0 0.48 1.01e-20 Cognitive test performance; CRC cis rs12477438 0.748 rs10200974 chr2:99675227 A/G cg14399236 chr2:99771627 LIPT1;TSGA10 -0.6 -8.19 -0.41 6.03e-15 Chronic sinus infection; CRC cis rs921968 0.565 rs6708192 chr2:219592227 A/G cg02176678 chr2:219576539 TTLL4 -0.4 -6.29 -0.33 9.87e-10 Mean corpuscular hemoglobin concentration; CRC cis rs6840360 1.000 rs7439465 chr4:152594814 C/T cg09659197 chr4:152720779 NA -0.52 -10.87 -0.51 1.02e-23 Intelligence (multi-trait analysis); CRC cis rs41005 0.967 rs1974696 chr2:8115782 A/G cg03155496 chr2:8117019 LOC339788 0.4 7.25 0.37 3.02e-12 Response to anti-TNF therapy in rheumatoid arthritis; CRC cis rs9291683 0.595 rs11722930 chr4:10035454 G/A cg00071950 chr4:10020882 SLC2A9 0.67 12.67 0.57 3.05e-30 Bone mineral density; CRC cis rs9467773 0.587 rs10946812 chr6:26344975 G/C cg14345882 chr6:26364793 BTN3A2 0.4 6.23 0.32 1.42e-9 Intelligence (multi-trait analysis); CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg04554905 chr3:172428857 NCEH1 -0.51 -6.09 -0.32 3.1e-9 Diisocyanate-induced asthma; CRC cis rs916888 0.821 rs199505 chr17:44859410 A/G cg15921436 chr17:44337874 NA -0.68 -7.81 -0.4 7.78e-14 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs9611565 0.765 rs132905 chr22:41799106 C/A cg06634786 chr22:41940651 POLR3H 0.62 7.22 0.37 3.61e-12 Vitiligo; CRC cis rs3806843 0.521 rs246061 chr5:140324656 C/A cg19875535 chr5:140030758 IK 0.39 6.02 0.31 4.67e-9 Depressive symptoms (multi-trait analysis); CRC cis rs6951245 0.872 rs76713558 chr7:1095866 A/G cg03188948 chr7:1209495 NA 0.66 6.94 0.36 2.04e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs9322193 0.923 rs9371207 chr6:150179223 A/G cg13206674 chr6:150067644 NUP43 0.64 8.98 0.44 2.09e-17 Lung cancer; CRC cis rs853679 0.517 rs17711801 chr6:28092307 C/G cg02631126 chr6:28058918 ZSCAN12L1 0.29 5.89 0.31 9.41e-9 Depression; CRC cis rs6674176 0.569 rs11210935 chr1:44369444 G/A cg12908607 chr1:44402522 ARTN -0.47 -8.34 -0.42 2.04e-15 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Cognitive ability; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg09626274 chr15:77224230 RCN2 0.42 6.51 0.34 2.85e-10 Liver disease severity in Alagille syndrome; CRC cis rs7615952 0.641 rs4490307 chr3:125712676 T/G cg15145296 chr3:125709740 NA -0.57 -7.35 -0.38 1.59e-12 Blood pressure (smoking interaction); CRC trans rs9467711 0.559 rs9348721 chr6:26485573 A/G cg06606381 chr12:133084897 FBRSL1 -0.79 -6.26 -0.33 1.22e-9 Autism spectrum disorder or schizophrenia; CRC cis rs6570726 0.577 rs406868 chr6:145809983 C/T cg05347473 chr6:146136440 FBXO30 0.47 6.77 0.35 5.88e-11 Lobe attachment (rater-scored or self-reported); CRC cis rs938554 0.737 rs10939637 chr4:9977577 A/G cg11266682 chr4:10021025 SLC2A9 0.35 5.64 0.3 3.62e-8 Blood metabolite levels; CRC cis rs7223966 1.000 rs78172786 chr17:61847114 A/C cg05941027 chr17:61774174 LIMD2 0.34 5.74 0.3 2.2e-8 Hip circumference adjusted for BMI;Body mass index; CRC cis rs2070488 0.775 rs2300669 chr3:38541318 C/A cg01465620 chr3:38496096 LOC100128640;ACVR2B -0.69 -11.42 -0.53 1.16e-25 Electrocardiographic conduction measures; CRC trans rs3733585 0.598 rs28677023 chr4:9958326 C/A cg26043149 chr18:55253948 FECH -0.5 -7.62 -0.39 2.81e-13 Cleft plate (environmental tobacco smoke interaction); CRC cis rs2624839 0.704 rs13067082 chr3:50221715 A/G cg05623727 chr3:50126028 RBM5 -0.4 -6.08 -0.32 3.36e-9 Intelligence (multi-trait analysis); CRC trans rs10504229 1.000 rs73609762 chr8:58192695 A/G cg04077850 chr5:125800366 GRAMD3 0.37 6.27 0.33 1.15e-9 Developmental language disorder (linguistic errors); CRC cis rs9905704 0.918 rs430973 chr17:56709206 T/G cg12560992 chr17:57184187 TRIM37 0.56 7.63 0.39 2.5e-13 Testicular germ cell tumor; CRC cis rs9527 0.590 rs10883820 chr10:104764661 A/C cg15744005 chr10:104629667 AS3MT 0.31 6.18 0.32 1.86e-9 Arsenic metabolism; CRC trans rs4942242 1.000 rs7335094 chr13:44223936 T/C cg19169023 chr15:41853346 TYRO3 -0.51 -7.77 -0.39 1.04e-13 Response to tocilizumab in rheumatoid arthritis; CRC cis rs453301 0.682 rs2929451 chr8:9085295 A/T cg06636001 chr8:8085503 FLJ10661 0.58 9.34 0.46 1.49e-18 Joint mobility (Beighton score); CRC cis rs11098499 0.738 rs34566984 chr4:120361270 G/A cg09307838 chr4:120376055 NA 0.72 11.14 0.52 1.1e-24 Corneal astigmatism; CRC cis rs9303401 0.614 rs3803752 chr17:56540267 C/T cg02118635 chr17:56770003 RAD51C;TEX14 0.8 9.4 0.46 9.71e-19 Cognitive test performance; CRC trans rs875971 0.660 rs2191268 chr7:66110224 C/T cg07203134 chr3:171178176 TNIK -0.45 -6.92 -0.36 2.44e-11 Aortic root size; CRC cis rs9648716 1.000 rs10261732 chr7:140570145 C/T cg10747023 chr7:140774559 NA 0.44 5.62 0.3 4.04e-8 Type 2 diabetes; CRC trans rs4843747 0.671 rs4072871 chr16:88106614 C/T cg26811252 chr16:29126840 RRN3P2 0.62 8.46 0.42 8.62e-16 Menopause (age at onset); CRC cis rs10540 1.000 rs10540 chr11:494662 G/A cg19913688 chr11:428466 ANO9 -0.7 -7.21 -0.37 3.76e-12 Body mass index; CRC cis rs6502050 0.835 rs4789672 chr17:80126603 T/C cg11859384 chr17:80120422 CCDC57 -0.36 -5.6 -0.3 4.51e-8 Life satisfaction; CRC cis rs6952808 0.636 rs6964522 chr7:1953523 C/T cg04267008 chr7:1944627 MAD1L1 -0.67 -10.49 -0.5 2.14e-22 Bipolar disorder and schizophrenia; CRC cis rs3204270 0.759 rs8066217 chr17:79672615 C/G cg18367735 chr17:79674897 NA 0.51 5.89 0.31 9.43e-9 Dental caries; CRC cis rs7591163 0.959 rs2396497 chr2:228724139 T/C cg14329157 chr2:228736135 WDR69 -0.45 -6.22 -0.32 1.52e-9 Blood pressure; CRC cis rs9322817 0.691 rs2400072 chr6:105344116 C/T cg02098413 chr6:105308735 HACE1 0.46 9.14 0.45 6.64e-18 Thyroid stimulating hormone; CRC cis rs1997103 1.000 rs6958664 chr7:55404958 T/G cg17469321 chr7:55412551 NA 0.72 11.3 0.53 3.17e-25 QRS interval (sulfonylurea treatment interaction); CRC cis rs10911232 0.507 rs4483371 chr1:182988352 G/A ch.1.3577855R chr1:183094577 LAMC1 0.86 15.22 0.64 5.91e-40 Hypertriglyceridemia; CRC cis rs1799949 0.965 rs6503727 chr17:41312859 C/T cg05368731 chr17:41323189 NBR1 0.57 8.55 0.43 4.79e-16 Menopause (age at onset); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg24327803 chr21:27108210 ATP5J;GABPA 0.46 6.41 0.33 4.96e-10 Response to antipsychotic treatment; CRC cis rs2019137 0.539 rs11123170 chr2:113978940 C/G cg07594247 chr2:113993304 PAX8;LOC440839;LOC654433 0.5 7.51 0.38 5.7e-13 Lymphocyte counts; CRC cis rs9322193 0.923 rs55993747 chr6:149943152 A/G cg13206674 chr6:150067644 NUP43 0.67 10.12 0.49 4.01e-21 Lung cancer; CRC cis rs17270561 0.636 rs6456697 chr6:25741434 A/G cg16482183 chr6:26056742 HIST1H1C 0.83 10.69 0.51 4.46e-23 Iron status biomarkers; CRC cis rs2070488 0.662 rs6599203 chr3:38487802 G/A cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.58 8.55 0.43 4.65e-16 Electrocardiographic conduction measures; CRC cis rs3617 0.539 rs12629687 chr3:52950659 T/C cg15147215 chr3:52552868 STAB1 0.45 7.5 0.38 6.17e-13 Red blood cell count;Autism spectrum disorder or schizophrenia; CRC cis rs6964587 0.904 rs6465339 chr7:91570790 T/A cg17063962 chr7:91808500 NA -0.82 -14.36 -0.62 1.23e-36 Breast cancer; CRC cis rs6121246 0.821 rs7265413 chr20:30317923 G/A cg18721089 chr20:30220636 NA -0.34 -5.63 -0.3 3.77e-8 Mean corpuscular hemoglobin; CRC trans rs10982213 0.830 rs2274163 chr9:117188714 C/T cg09305948 chr7:5254072 WIPI2 -0.37 -6.06 -0.32 3.82e-9 Interleukin-6 levels; CRC cis rs972578 0.806 rs5759008 chr22:43274367 A/T cg01576275 chr22:43409880 NA -0.41 -6.45 -0.33 4.05e-10 Mean platelet volume; CRC cis rs4557101 0.526 rs7627890 chr3:73532069 C/T cg24173753 chr3:73529447 PDZRN3 -0.36 -5.78 -0.3 1.73e-8 QT interval; CRC cis rs7737355 0.947 rs739952 chr5:130796568 A/T cg06307176 chr5:131281290 NA -0.43 -6.43 -0.33 4.55e-10 Life satisfaction; CRC cis rs12024301 0.557 rs4325101 chr1:183644070 C/A cg11505048 chr1:183622726 RGL1;APOBEC4 0.78 6.99 0.36 1.52e-11 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs7666738 0.830 rs35213297 chr4:98984049 T/C cg17366294 chr4:99064904 C4orf37 0.43 7.21 0.37 3.91e-12 Colonoscopy-negative controls vs population controls; CRC cis rs7615952 0.599 rs6766327 chr3:125723677 C/G cg06494592 chr3:125709126 NA -0.55 -6.58 -0.34 1.88e-10 Blood pressure (smoking interaction); CRC cis rs6952808 0.692 rs12666575 chr7:2004421 C/T cg00106254 chr7:1943704 MAD1L1 -0.52 -7.51 -0.38 5.46e-13 Bipolar disorder and schizophrenia; CRC cis rs425277 0.583 rs12059660 chr1:2041461 C/T cg12639453 chr1:2035780 PRKCZ -0.38 -7.31 -0.37 2e-12 Height; CRC cis rs514406 0.708 rs514881 chr1:53336737 A/G cg27535305 chr1:53392650 SCP2 0.42 7.73 0.39 1.34e-13 Monocyte count; CRC cis rs6840360 0.533 rs13147021 chr4:152722688 A/C cg09659197 chr4:152720779 NA -0.42 -8.69 -0.43 1.79e-16 Intelligence (multi-trait analysis); CRC trans rs4902562 0.838 rs6573823 chr14:68733632 A/G cg00520622 chr21:27107799 ATP5J;GABPA 0.47 6.01 0.31 4.82e-9 Systemic lupus erythematosus; CRC cis rs561341 1.000 rs546519 chr17:30297682 T/G cg23018236 chr17:30244563 NA -0.57 -7.48 -0.38 6.78e-13 Hip circumference adjusted for BMI; CRC cis rs8060686 0.920 rs73591976 chr16:67811590 C/A cg10544611 chr16:67998164 SLC12A4 -0.53 -5.64 -0.3 3.66e-8 HDL cholesterol;Metabolic syndrome; CRC cis rs3736485 0.609 rs744039 chr15:51973373 T/C cg08986416 chr15:51914746 DMXL2 -0.39 -5.65 -0.3 3.54e-8 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs8060686 0.641 rs28548264 chr16:68211321 A/G cg08314208 chr16:67682810 RLTPR -0.49 -5.88 -0.31 9.81e-9 HDL cholesterol;Metabolic syndrome; CRC cis rs8067545 0.611 rs7216599 chr17:20015600 G/C cg13482628 chr17:19912719 NA 0.45 7.05 0.36 1.07e-11 Schizophrenia; CRC cis rs3785574 0.962 rs8079161 chr17:61808561 C/G cg22520471 chr17:61851767 DDX42;CCDC47 0.44 6.13 0.32 2.56e-9 Height; CRC cis rs73200209 0.744 rs55837280 chr12:116645483 A/G cg01776926 chr12:116560359 MED13L -0.61 -7.08 -0.36 8.97e-12 Total body bone mineral density; CRC cis rs9372498 0.536 rs72954806 chr6:118899965 C/G cg01339444 chr6:118972232 C6orf204 0.53 5.94 0.31 7.25e-9 Diastolic blood pressure; CRC cis rs7727544 0.507 rs11741341 chr5:131570218 A/G cg04518342 chr5:131593106 PDLIM4 0.51 9.27 0.46 2.44e-18 Blood metabolite levels; CRC cis rs4689388 0.890 rs4688991 chr4:6302220 C/G cg14416269 chr4:6271139 WFS1 0.39 6.38 0.33 5.88e-10 Type 2 diabetes and other traits;Type 2 diabetes; CRC cis rs9488822 0.636 rs10872142 chr6:116369052 C/A cg05304507 chr6:116381966 FRK 0.3 8.06 0.41 1.45e-14 Cholesterol, total;LDL cholesterol; CRC cis rs597539 0.652 rs496616 chr11:68672800 G/C cg21963583 chr11:68658836 MRPL21 0.62 11.35 0.53 2.04e-25 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs394563 0.775 rs448420 chr6:149785802 T/C cg16235748 chr6:149772707 ZC3H12D -0.38 -6.53 -0.34 2.56e-10 Dupuytren's disease; CRC cis rs3741151 1.000 rs75007932 chr11:73080336 G/A cg17517138 chr11:73019481 ARHGEF17 1.11 9.39 0.46 1.06e-18 GIP levels in response to oral glucose tolerance test (120 minutes); CRC trans rs916888 0.821 rs199525 chr17:44847834 T/G cg13957321 chr17:43675089 NA 0.53 6.32 0.33 8.34e-10 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs780096 0.546 rs1647284 chr2:27608115 C/T cg12648201 chr2:27665141 KRTCAP3 -0.29 -5.75 -0.3 1.99e-8 Total body bone mineral density; CRC cis rs11997175 0.574 rs4520125 chr8:33648628 C/T cg04338863 chr8:33670619 NA 0.4 6.84 0.35 3.8e-11 Body mass index; CRC cis rs58688157 0.705 rs36060383 chr11:598723 A/C cg16486109 chr11:613632 IRF7 0.73 12.46 0.57 1.94e-29 Systemic lupus erythematosus; CRC cis rs1790761 0.587 rs4930430 chr11:67294198 A/G cg00290607 chr11:67383545 NA 0.33 5.71 0.3 2.48e-8 Mean corpuscular volume; CRC cis rs9908102 0.740 rs8079600 chr17:12910706 T/C cg26162695 chr17:12921313 ELAC2 0.43 5.85 0.31 1.17e-8 Schizophrenia; CRC cis rs11098499 0.863 rs36040693 chr4:120477616 A/G cg09307838 chr4:120376055 NA 0.67 10.02 0.48 8.25e-21 Corneal astigmatism; CRC cis rs113835537 0.529 rs57724777 chr11:66236431 G/A cg22134325 chr11:66188745 NPAS4 0.28 5.65 0.3 3.39e-8 Airway imaging phenotypes; CRC cis rs7246967 0.551 rs8103204 chr19:22936517 T/A cg08271804 chr19:22816896 ZNF492 0.38 5.86 0.31 1.11e-8 Bronchopulmonary dysplasia; CRC cis rs7804356 1.000 rs10272190 chr7:26887942 T/A cg03456212 chr7:26904342 SKAP2 -0.49 -5.63 -0.3 3.89e-8 Type 1 diabetes; CRC trans rs7726839 0.561 rs56410216 chr5:583216 C/A cg25482853 chr8:67687455 SGK3 1.01 12.23 0.56 1.32e-28 Obesity-related traits; CRC cis rs7113874 0.550 rs4929949 chr11:8604593 T/C cg17679104 chr11:8615758 STK33 0.36 6.02 0.32 4.6e-9 Body mass index in physically active individuals;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs6570726 0.935 rs430561 chr6:145813140 C/T cg23711669 chr6:146136114 FBXO30 0.68 12.17 0.56 2.25e-28 Lobe attachment (rater-scored or self-reported); CRC cis rs11711311 1.000 rs11719303 chr3:113494524 A/T cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.52 -7.1 -0.36 7.56e-12 IgG glycosylation; CRC cis rs972578 1.000 rs4822244 chr22:43389028 C/T cg01576275 chr22:43409880 NA -0.49 -7.91 -0.4 3.96e-14 Mean platelet volume; CRC cis rs1545257 0.514 rs7581577 chr2:24638107 C/T cg06627628 chr2:24431161 ITSN2 -0.47 -7.02 -0.36 1.27e-11 Sjögren's syndrome; CRC cis rs12995491 0.843 rs1878809 chr2:88518315 C/T cg14558114 chr2:88469736 THNSL2 -0.39 -6.03 -0.32 4.46e-9 Response to metformin (IC50); CRC cis rs1538970 1.000 rs1417578 chr1:45850590 A/G cg05343316 chr1:45956843 TESK2 0.61 8.45 0.42 9.8e-16 Platelet count; CRC cis rs4665809 1.000 rs11126364 chr2:26314515 A/G cg25036284 chr2:26402008 FAM59B -0.46 -6.03 -0.32 4.3e-9 Gut microbiome composition (summer); CRC cis rs11758351 0.660 rs55643278 chr6:26222888 C/A cg01420254 chr6:26195488 NA 0.76 8.36 0.42 1.81e-15 Gout;Renal underexcretion gout; CRC cis rs10771431 0.967 rs7137443 chr12:9372029 C/T cg08997352 chr12:9597637 DDX12 -0.41 -6.08 -0.32 3.4e-9 Breast size; CRC cis rs939574 1.000 rs2071385 chr2:220118782 T/G cg00496455 chr2:220118770 TUBA4A;TUBA4B 0.89 9.38 0.46 1.13e-18 Platelet distribution width; CRC cis rs853679 0.517 rs16893666 chr6:28054707 C/T cg12172441 chr6:28176163 NA -0.61 -7.31 -0.37 2.1e-12 Depression; CRC cis rs9381040 0.655 rs9381032 chr6:41044986 A/T cg04346459 chr6:41068666 NFYA;LOC221442 -0.42 -6.22 -0.32 1.49e-9 Alzheimer's disease (late onset); CRC cis rs11148252 0.538 rs9535880 chr13:52706143 G/A cg12458913 chr13:53173898 NA 0.45 6.55 0.34 2.19e-10 Lewy body disease; CRC cis rs7666738 0.830 rs4699588 chr4:98973789 A/G cg05340658 chr4:99064831 C4orf37 0.6 9.35 0.46 1.41e-18 Colonoscopy-negative controls vs population controls; CRC cis rs9443189 1.000 rs1280044 chr6:76522602 A/G cg01950844 chr6:76311363 SENP6 -0.54 -6.4 -0.33 5.34e-10 Prostate cancer; CRC cis rs7940866 0.874 rs11222406 chr11:130814093 A/G cg12179176 chr11:130786555 SNX19 0.6 8.82 0.44 6.9e-17 Schizophrenia; CRC cis rs6500395 0.926 rs11643272 chr16:48639723 T/C cg04672837 chr16:48644449 N4BP1 0.44 6.4 0.33 5.42e-10 Response to tocilizumab in rheumatoid arthritis; CRC cis rs3106136 0.872 rs10030713 chr4:95238536 C/G cg11021082 chr4:95130006 SMARCAD1 -0.44 -6.6 -0.34 1.63e-10 Capecitabine sensitivity; CRC cis rs12908161 0.920 rs35758837 chr15:85311382 C/T cg11189052 chr15:85197271 WDR73 0.58 8.43 0.42 1.1e-15 Schizophrenia; CRC cis rs798554 0.757 rs2644312 chr7:2841164 G/A cg19717773 chr7:2847554 GNA12 -0.48 -7.06 -0.36 9.65e-12 Height; CRC cis rs7447593 0.666 rs10866705 chr5:176801131 G/T cg06060754 chr5:176797920 RGS14 -0.65 -10.4 -0.5 4.43e-22 Urinary electrolytes (magnesium/calcium ratio); CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg05421101 chr16:23568813 UBFD1;EARS2 0.47 6.5 0.34 2.99e-10 Anxiety disorder; CRC cis rs7647973 1.000 rs8897 chr3:49460407 A/G cg20833759 chr3:49053208 WDR6;DALRD3 0.5 7.71 0.39 1.51e-13 Menarche (age at onset); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg16703956 chr5:1446217 SLC6A3 0.21 6.06 0.32 3.68e-9 Liver disease severity in Alagille syndrome; CRC cis rs908922 0.676 rs4845780 chr1:152488846 T/G cg23254163 chr1:152506842 NA 0.5 10.05 0.48 6.51e-21 Hair morphology; CRC cis rs9467773 0.587 rs10946813 chr6:26345141 A/G cg14345882 chr6:26364793 BTN3A2 -0.38 -6.1 -0.32 3.03e-9 Intelligence (multi-trait analysis); CRC cis rs9527 0.590 rs7073323 chr10:104797423 A/C cg04362960 chr10:104952993 NT5C2 0.58 8.22 0.41 4.66e-15 Arsenic metabolism; CRC cis rs6951245 0.529 rs76001997 chr7:1152615 C/T cg24642844 chr7:1081250 C7orf50 -0.46 -6.0 -0.31 5.3e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs28386778 0.897 rs57108948 chr17:61802378 T/C cg25654072 chr17:61904446 PSMC5;FTSJ3 0.72 11.05 0.52 2.36e-24 Prudent dietary pattern; CRC cis rs4148883 0.675 rs28762430 chr4:100119257 C/A cg12011299 chr4:100065546 ADH4 0.5 10.93 0.52 6.28e-24 Alcohol dependence; CRC trans rs1455244 0.700 rs7229302 chr18:11508904 G/T cg26125625 chr3:124860871 SLC12A8 0.2 6.06 0.32 3.82e-9 Schizophrenia; CRC cis rs9303401 0.614 rs62084384 chr17:57126842 G/A cg10487724 chr17:56770010 TEX14;RAD51C 0.76 8.96 0.44 2.45e-17 Cognitive test performance; CRC cis rs11098499 0.954 rs12502423 chr4:120424172 A/C cg09307838 chr4:120376055 NA 0.73 11.23 0.53 5.33e-25 Corneal astigmatism; CRC trans rs2797160 0.651 rs1268066 chr6:126035041 C/T cg05039488 chr6:79577232 IRAK1BP1 0.56 8.53 0.43 5.29e-16 Endometrial cancer; CRC cis rs35306767 0.953 rs11253509 chr10:964306 C/T cg26597838 chr10:835615 NA 0.82 10.26 0.49 1.31e-21 Eosinophil percentage of granulocytes; CRC trans rs9929218 0.954 rs12924033 chr16:68822599 G/A cg04657470 chr2:198365150 HSPE1;HSPD1 -0.73 -10.55 -0.5 1.37e-22 Colorectal cancer; CRC cis rs4660306 0.677 rs6429566 chr1:45941852 T/C cg03123370 chr1:45965343 CCDC163P;MMACHC -0.51 -6.73 -0.35 7.76e-11 Homocysteine levels; CRC trans rs12599106 0.792 rs76039834 chr16:34598453 G/A cg15383120 chr6:291909 DUSP22 -0.51 -7.27 -0.37 2.71e-12 Menopause (age at onset); CRC cis rs17001868 0.568 rs12484697 chr22:40736472 A/G cg07138101 chr22:40742427 ADSL -0.58 -7.78 -0.39 9.14e-14 Mammographic density (dense area); CRC cis rs10504229 1.000 rs9650139 chr8:58190508 G/T cg01721255 chr8:58191610 C8orf71 0.49 6.14 0.32 2.4e-9 Developmental language disorder (linguistic errors); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg25291941 chr8:99129319 POP1;HRSP12 0.51 8.37 0.42 1.72e-15 Liver disease severity in Alagille syndrome; CRC trans rs62103177 0.810 rs62103191 chr18:77628769 C/G cg05926928 chr17:57297772 GDPD1 1.06 9.98 0.48 1.12e-20 Opioid sensitivity; CRC cis rs72945132 0.882 rs7118156 chr11:70142922 T/C cg00319359 chr11:70116639 PPFIA1 0.68 7.51 0.38 5.61e-13 Coronary artery disease; CRC cis rs3015497 0.586 rs12587842 chr14:51092562 A/G cg09863266 chr14:51125203 SAV1 -0.3 -5.76 -0.3 1.92e-8 Mean platelet volume; CRC cis rs11191205 0.686 rs11191091 chr10:103448649 C/A cg15320455 chr10:103880129 LDB1 0.57 6.21 0.32 1.56e-9 Intelligence (multi-trait analysis); CRC cis rs4665809 1.000 rs11126364 chr2:26314515 A/G cg27170947 chr2:26402098 FAM59B -0.45 -6.06 -0.32 3.68e-9 Gut microbiome composition (summer); CRC cis rs1862618 0.853 rs6450409 chr5:56101399 A/G cg03609598 chr5:56110824 MAP3K1 -0.8 -9.78 -0.47 5.31e-20 Initial pursuit acceleration; CRC cis rs875971 0.862 rs6955837 chr7:66043142 C/T cg11764359 chr7:65958608 NA -0.59 -8.75 -0.43 1.12e-16 Aortic root size; CRC trans rs3942852 0.524 rs7118665 chr11:48078427 C/A cg03929089 chr4:120376271 NA 0.56 7.75 0.39 1.17e-13 Acute lymphoblastic leukemia (childhood); CRC cis rs7044106 0.762 rs10760107 chr9:123383630 T/C cg09586646 chr9:123605570 PSMD5;LOC253039 0.62 8.78 0.44 8.78e-17 Hip circumference adjusted for BMI; CRC cis rs7845219 0.597 rs7002058 chr8:95873993 G/C cg09323728 chr8:95962352 TP53INP1 -0.37 -6.01 -0.31 4.9e-9 Type 2 diabetes; CRC cis rs919433 0.783 rs787980 chr2:198239225 C/T cg03934865 chr2:198174659 NA 0.36 5.81 0.31 1.44e-8 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC cis rs9611519 0.780 rs2235849 chr22:41653540 T/G cg03806693 chr22:41940476 POLR3H -0.58 -8.34 -0.42 2e-15 Neuroticism; CRC trans rs2727020 0.638 rs1164668 chr11:49330627 A/C cg21153622 chr11:89784906 NA 0.44 7.19 0.37 4.26e-12 Coronary artery disease; CRC cis rs11969893 0.850 rs9498409 chr6:101299966 G/A cg12253828 chr6:101329408 ASCC3 1.19 9.37 0.46 1.17e-18 Economic and political preferences (immigration/crime); CRC cis rs7216064 0.911 rs6504551 chr17:65903326 T/G cg12091567 chr17:66097778 LOC651250 -0.67 -8.98 -0.44 2.15e-17 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CRC cis rs2836974 0.932 rs11910151 chr21:40560262 T/C cg17971929 chr21:40555470 PSMG1 0.85 12.8 0.58 9.97e-31 Cognitive function; CRC cis rs6502050 0.871 rs8082577 chr17:80070581 T/C cg22110888 chr17:80059540 CCDC57 -0.42 -6.54 -0.34 2.38e-10 Life satisfaction; CRC cis rs763121 0.853 rs1569492 chr22:38975511 A/G cg06544989 chr22:39130855 UNC84B -0.47 -7.65 -0.39 2.31e-13 Menopause (age at onset); CRC cis rs2760061 0.659 rs708107 chr1:228189495 C/T cg02753203 chr1:228287806 NA 0.67 9.98 0.48 1.19e-20 Diastolic blood pressure; CRC trans rs11165623 0.740 rs11165638 chr1:96921357 C/A cg10631902 chr5:14652156 NA -0.53 -10.0 -0.48 9.74e-21 Hip circumference;Waist circumference; CRC cis rs8038465 0.622 rs710086 chr15:73877001 C/T cg15420318 chr15:73925796 NPTN 0.44 6.93 0.36 2.28e-11 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs4665809 0.878 rs6720312 chr2:26364934 A/G cg04944784 chr2:26401820 FAM59B 0.65 7.73 0.39 1.28e-13 Gut microbiome composition (summer); CRC trans rs9467711 0.606 rs2235251 chr6:26431982 C/T cg06606381 chr12:133084897 FBRSL1 -0.85 -6.39 -0.33 5.62e-10 Autism spectrum disorder or schizophrenia; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg11688275 chr8:128750871 MYC 0.41 5.99 0.31 5.35e-9 Response to antipsychotic treatment; CRC cis rs3751196 0.808 rs74503365 chr12:104212665 G/A cg02344784 chr12:104178138 NT5DC3 0.71 7.54 0.38 4.58e-13 Sense of smell; CRC cis rs2692947 0.667 rs4144055 chr2:96647856 G/T cg23100626 chr2:96804247 ASTL 0.26 6.95 0.36 2.01e-11 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; CRC trans rs10504229 1.000 rs3814486 chr8:58191226 A/T cg04077850 chr5:125800366 GRAMD3 0.37 6.27 0.33 1.15e-9 Developmental language disorder (linguistic errors); CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg24859228 chr10:12391835 CAMK1D -0.51 -6.09 -0.32 3.23e-9 Diisocyanate-induced asthma; CRC cis rs17152411 0.895 rs7914206 chr10:126585397 G/A cg07906193 chr10:126599966 NA 0.57 6.28 0.33 1.06e-9 Height; CRC trans rs634534 0.532 rs12794370 chr11:65770413 G/A cg17712092 chr4:129076599 LARP1B 0.67 11.08 0.52 1.89e-24 Sum eosinophil basophil counts;Eosinophil counts; CRC cis rs2735413 0.881 rs12918547 chr16:78082746 G/A cg04733911 chr16:78082701 NA -0.45 -7.41 -0.38 1.11e-12 Systolic blood pressure (alcohol consumption interaction); CRC cis rs9814567 0.929 rs9838834 chr3:134207077 G/A cg06109529 chr3:134205091 CEP63;ANAPC13 -0.82 -12.25 -0.56 1.09e-28 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs10924970 0.625 rs10802624 chr1:235494971 A/G cg09010748 chr1:235293032 TOMM20 -0.46 -6.27 -0.33 1.15e-9 Asthma; CRC cis rs9534288 0.797 rs1134071 chr13:46562935 A/G cg15192986 chr13:46630673 CPB2 -0.68 -9.88 -0.48 2.52e-20 Blood protein levels; CRC cis rs1799949 0.930 rs33968979 chr17:41297992 G/T cg25072359 chr17:41440525 NA 0.46 6.97 0.36 1.79e-11 Menopause (age at onset); CRC cis rs6502050 0.805 rs6502057 chr17:80082060 A/G cg13198984 chr17:80129470 CCDC57 -0.5 -8.77 -0.44 1.01e-16 Life satisfaction; CRC cis rs35110281 0.667 rs2070533 chr21:45122753 G/A cg21573476 chr21:45109991 RRP1B -0.39 -5.77 -0.3 1.79e-8 Mean corpuscular volume; CRC cis rs1005277 0.522 rs200943 chr10:38148730 A/G cg25427524 chr10:38739819 LOC399744 -0.75 -13.13 -0.59 5.84e-32 Extrinsic epigenetic age acceleration; CRC cis rs9487051 0.837 rs9480920 chr6:109605322 C/A cg12927641 chr6:109611667 NA -0.38 -6.77 -0.35 6.05e-11 Reticulocyte fraction of red cells; CRC cis rs473651 0.904 rs551859 chr2:239371836 T/C cg21699342 chr2:239360505 ASB1 0.54 9.56 0.47 2.85e-19 Multiple system atrophy; CRC cis rs3736485 0.932 rs4775966 chr15:51913788 A/G cg08986416 chr15:51914746 DMXL2 -0.44 -6.27 -0.33 1.12e-9 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs4862750 0.874 rs6822062 chr4:187895553 T/C cg10295955 chr4:187884368 NA -1.07 -28.34 -0.84 2.74e-90 Lobe attachment (rater-scored or self-reported); CRC cis rs2462686 0.932 rs2471557 chr7:46000595 G/C cg23193639 chr7:45961078 IGFBP3 -0.38 -5.86 -0.31 1.14e-8 Major depressive disorder; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg23186422 chr6:139013826 NA 0.47 6.71 0.35 8.41e-11 Anxiety disorder; CRC cis rs2160860 0.736 rs10958573 chr8:39797955 G/A cg11363097 chr8:39792086 IDO2 -0.42 -7.24 -0.37 3.23e-12 Blood metabolite levels; CRC cis rs155076 0.666 rs9509640 chr13:21872880 T/C cg06138931 chr13:21896616 NA 0.52 6.39 0.33 5.69e-10 White matter hyperintensity burden; CRC cis rs2976388 0.587 rs2717606 chr8:143799496 G/A cg24046110 chr8:143859143 LYNX1 0.48 8.34 0.42 2.11e-15 Urinary tract infection frequency; CRC cis rs5769765 0.773 rs7290751 chr22:50318312 T/C cg22709217 chr22:50311962 ALG12;CRELD2 -1.06 -15.43 -0.65 8.48e-41 Schizophrenia; CRC cis rs311392 0.966 rs425548 chr8:55087468 C/T cg06042504 chr8:55087323 NA -0.42 -6.5 -0.34 2.97e-10 Pelvic organ prolapse (moderate/severe); CRC cis rs1552244 1.000 rs67569278 chr3:10149893 T/C cg02579736 chr3:10068473 FANCD2;CIDECP 1.01 12.99 0.58 1.9e-31 Alzheimer's disease; CRC trans rs9467711 0.606 rs35076545 chr6:26603924 C/A cg06606381 chr12:133084897 FBRSL1 -1.07 -7.41 -0.38 1.09e-12 Autism spectrum disorder or schizophrenia; CRC cis rs7647973 0.593 rs7620848 chr3:49828021 G/C cg03060546 chr3:49711283 APEH -0.65 -7.89 -0.4 4.42e-14 Menarche (age at onset); CRC cis rs3820068 0.581 rs16851841 chr1:15922713 A/G cg27534772 chr1:16042836 PLEKHM2 0.54 10.43 0.5 3.54e-22 Systolic blood pressure; CRC cis rs2549003 1.000 rs2549002 chr5:131829578 C/A cg21138405 chr5:131827807 IRF1 -0.61 -12.15 -0.56 2.6e-28 Asthma (sex interaction); CRC cis rs6479527 0.904 rs1418251 chr9:96848077 T/C cg13460858 chr9:96720652 NA 0.31 5.7 0.3 2.62e-8 Esophageal adenocarcinoma; CRC cis rs9525927 0.625 rs4941488 chr13:44817758 T/C cg19190762 chr13:44806055 NA 0.54 6.37 0.33 6.22e-10 Dupuytren's disease; CRC cis rs2949837 0.581 rs1852210 chr7:45994256 C/T cg06713098 chr7:45960367 IGFBP3 0.42 6.67 0.35 1.05e-10 Sitting height ratio; CRC cis rs853679 0.517 rs1340004 chr6:28103691 C/T cg06470822 chr6:28175283 NA 1.02 13.67 0.6 5.35e-34 Depression; CRC cis rs728616 0.867 rs41302709 chr10:81807278 G/A cg05935833 chr10:81318306 SFTPA2 -0.47 -5.88 -0.31 9.99e-9 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs995000 0.931 rs1781195 chr1:62988972 T/C cg19896129 chr1:63156450 NA -0.45 -6.99 -0.36 1.56e-11 Triglyceride levels; CRC cis rs12477438 0.520 rs2632277 chr2:99778985 A/G cg26064155 chr2:99771622 LIPT1;TSGA10 0.87 16.03 0.66 3.98e-43 Chronic sinus infection; CRC cis rs9926296 0.546 rs6500442 chr16:89828862 T/C cg27121462 chr16:89883253 FANCA 0.56 8.82 0.44 6.8e-17 Vitiligo; CRC cis rs6429082 0.811 rs291348 chr1:235667690 A/G cg26050004 chr1:235667680 B3GALNT2 0.76 12.85 0.58 6.69e-31 Adiposity; CRC trans rs2303319 0.504 rs62189046 chr2:162612371 C/G cg22988483 chr14:93581567 ITPK1 -0.66 -6.07 -0.32 3.52e-9 Cognitive function; CRC cis rs2732480 0.538 rs2468943 chr12:48747249 G/T cg24011408 chr12:48396354 COL2A1 -0.42 -5.72 -0.3 2.36e-8 Hemoglobin concentration;Red blood cell count;Hematocrit; CRC cis rs28374715 0.662 rs72737792 chr15:41515589 G/C cg18705301 chr15:41695430 NDUFAF1 -0.88 -13.33 -0.59 1.08e-32 Ulcerative colitis; CRC cis rs853679 0.517 rs9380050 chr6:28048538 A/G cg25164649 chr6:28176230 NA 0.72 9.1 0.45 9.16e-18 Depression; CRC cis rs9393692 0.846 rs9366651 chr6:26336696 G/T cg05868516 chr6:26286170 HIST1H4H 0.39 5.66 0.3 3.31e-8 Educational attainment; CRC cis rs4268898 0.662 rs9917355 chr2:24433400 C/T cg06627628 chr2:24431161 ITSN2 -0.85 -11.58 -0.54 3.01e-26 Asthma; CRC cis rs62229266 0.804 rs880221 chr21:37420785 C/T cg08632701 chr21:37451849 NA -0.45 -7.09 -0.36 8.4e-12 Mitral valve prolapse; CRC cis rs853679 0.517 rs3757185 chr6:28107776 T/A cg25164649 chr6:28176230 NA 0.76 9.53 0.46 3.71e-19 Depression; CRC cis rs7224737 1.000 rs12603330 chr17:40290589 T/A cg00647820 chr17:40259828 DHX58 -0.46 -6.5 -0.34 3.04e-10 Fibrinogen levels; CRC trans rs6937795 0.898 rs6913178 chr6:137294204 G/A cg04282530 chr11:128530479 NA -0.39 -5.96 -0.31 6.44e-9 Type 2 diabetes; CRC cis rs9527 0.521 rs12259163 chr10:104961477 A/G cg04362960 chr10:104952993 NT5C2 0.61 8.37 0.42 1.71e-15 Arsenic metabolism; CRC trans rs703108 0.731 rs7898954 chr10:22323646 A/G cg00632778 chr13:50422122 NA -0.46 -6.09 -0.32 3.22e-9 Monocyte percentage of white cells; CRC cis rs9467711 0.606 rs9358937 chr6:26374274 C/G cg16898833 chr6:26189333 HIST1H4D 0.75 6.55 0.34 2.26e-10 Autism spectrum disorder or schizophrenia; CRC trans rs208515 0.525 rs12193034 chr6:66677866 C/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.93 11.75 0.54 7.28e-27 Exhaled nitric oxide levels; CRC cis rs28386778 0.897 rs2854214 chr17:61945449 C/G cg22520471 chr17:61851767 DDX42;CCDC47 -0.74 -11.38 -0.53 1.55e-25 Prudent dietary pattern; CRC cis rs9814567 1.000 rs9850015 chr3:134269541 G/C cg06109529 chr3:134205091 CEP63;ANAPC13 -0.81 -12.36 -0.56 4.47e-29 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs12220238 1.000 rs11000894 chr10:75906598 G/A cg19889307 chr10:75911429 ADK;AP3M1 0.61 5.72 0.3 2.37e-8 Soluble interleukin-2 receptor subunit alpha; CRC cis rs9399135 0.660 rs4472368 chr6:135274232 A/G cg24558204 chr6:135376177 HBS1L 0.51 7.74 0.39 1.21e-13 Red blood cell count; CRC cis rs77861329 0.800 rs6777340 chr3:52188308 T/C cg08692210 chr3:52188851 WDR51A 0.5 5.91 0.31 8.42e-9 Macrophage inflammatory protein 1b levels; CRC cis rs9916302 0.861 rs11078912 chr17:37671490 A/G cg07936489 chr17:37558343 FBXL20 -0.78 -11.57 -0.54 3.32e-26 Glomerular filtration rate (creatinine); CRC cis rs6831352 0.703 rs4235435 chr4:100039578 C/T cg12011299 chr4:100065546 ADH4 0.45 8.75 0.43 1.1e-16 Alcohol dependence; CRC cis rs9487051 0.676 rs7773213 chr6:109601885 C/T cg01475377 chr6:109611718 NA -0.39 -6.72 -0.35 8.04e-11 Reticulocyte fraction of red cells; CRC cis rs8020095 0.571 rs7156852 chr14:67340549 T/G cg00791868 chr14:66963628 C14orf53 0.45 5.75 0.3 2.09e-8 Depression (quantitative trait); CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg08857478 chr17:74722826 JMJD6;C17orf95 0.53 6.76 0.35 6.14e-11 Thyroid stimulating hormone; CRC cis rs2288073 0.965 rs10192600 chr2:24396680 A/G cg06627628 chr2:24431161 ITSN2 -0.73 -9.83 -0.48 3.62e-20 Venous thromboembolism (SNP x SNP interaction); CRC cis rs9894429 0.646 rs7406825 chr17:79619188 C/T cg18240062 chr17:79603768 NPLOC4 0.46 7.15 0.37 5.82e-12 Eye color traits; CRC cis rs853679 0.517 rs9393886 chr6:28050039 T/G cg02631126 chr6:28058918 ZSCAN12L1 0.29 5.95 0.31 7.04e-9 Depression; CRC cis rs457287 0.772 rs415719 chr9:4823007 G/T cg14182974 chr9:4791918 RCL1 0.4 6.21 0.32 1.55e-9 Platelet count; CRC cis rs864537 0.676 rs2056626 chr1:167420425 T/G cg09179987 chr1:167433047 CD247 0.49 7.68 0.39 1.85e-13 Celiac disease or Rheumatoid arthritis;Celiac disease; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg17851730 chr1:19229128 ALDH4A1 0.47 6.56 0.34 2.05e-10 Response to antipsychotic treatment; CRC cis rs11212617 0.967 rs186594 chr11:108265854 A/T cg12106634 chr11:108092400 ATM;NPAT 0.43 6.5 0.34 3.04e-10 Response to metformin in type 2 diabetes (glycemic); CRC cis rs758324 0.898 rs6877358 chr5:131111360 G/A cg06307176 chr5:131281290 NA 0.43 6.35 0.33 7.09e-10 Alzheimer's disease in APOE e4- carriers; CRC cis rs611744 0.604 rs6469170 chr8:109305277 T/C cg21045802 chr8:109455806 TTC35 0.46 7.03 0.36 1.22e-11 Dupuytren's disease; CRC cis rs9467773 0.869 rs1796520 chr6:26410800 C/T cg09904177 chr6:26538194 HMGN4 -0.67 -9.88 -0.48 2.58e-20 Intelligence (multi-trait analysis); CRC cis rs7727544 0.571 rs12521097 chr5:131575338 G/A cg00255919 chr5:131827918 IRF1 -0.31 -5.66 -0.3 3.37e-8 Blood metabolite levels; CRC cis rs832540 0.898 rs331497 chr5:56251660 G/T cg20203395 chr5:56204925 C5orf35 0.41 5.98 0.31 5.81e-9 Coronary artery disease; CRC cis rs780096 0.526 rs75855890 chr2:27625005 G/T cg02592271 chr2:27665507 KRTCAP3 -0.27 -5.85 -0.31 1.18e-8 Total body bone mineral density; CRC cis rs12908161 0.959 rs34784022 chr15:85231906 T/C cg11189052 chr15:85197271 WDR73 0.62 8.86 0.44 4.93e-17 Schizophrenia; CRC cis rs6942756 1.000 rs2718084 chr7:128897342 T/C cg02491457 chr7:128862824 NA 0.66 8.93 0.44 3.13e-17 White matter hyperintensity burden; CRC cis rs755249 0.567 rs16826009 chr1:39716902 A/G cg18385671 chr1:39797026 MACF1 -0.42 -5.99 -0.31 5.5e-9 Peripheral arterial disease (traffic-related air pollution interaction); CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg18520411 chr19:19516967 GATAD2A 0.47 6.08 0.32 3.31e-9 Thyroid stimulating hormone; CRC cis rs2836950 0.565 rs3171465 chr21:40552307 A/G cg11890956 chr21:40555474 PSMG1 -0.64 -9.58 -0.47 2.44e-19 Menarche (age at onset); CRC cis rs933688 0.877 rs10474352 chr5:90732225 C/T cg02339078 chr5:90679543 LOC100129716;ARRDC3 0.89 13.5 0.6 2.43e-33 Smoking behavior; CRC cis rs7959452 0.605 rs12819406 chr12:69696400 G/T cg14784868 chr12:69753453 YEATS4 0.75 12.12 0.56 3.32e-28 Blood protein levels; CRC trans rs561341 0.714 rs473535 chr17:30312365 A/G cg27661571 chr11:113659931 NA -0.95 -11.06 -0.52 2.1e-24 Hip circumference adjusted for BMI; CRC cis rs798554 0.836 rs2260230 chr7:2822986 T/A cg13628971 chr7:2884303 GNA12 0.54 7.33 0.37 1.81e-12 Height; CRC cis rs738322 0.600 rs6001031 chr22:38556260 G/T cg25457927 chr22:38595422 NA 0.31 6.35 0.33 7.18e-10 Cutaneous nevi; CRC trans rs2832077 0.527 rs9981922 chr21:30212718 A/G cg14791747 chr16:20752902 THUMPD1 0.68 11.03 0.52 2.88e-24 Cognitive test performance; CRC cis rs12188164 0.965 rs1056465 chr5:442438 T/A cg17553881 chr5:443987 EXOC3;C5orf55 -0.37 -7.65 -0.39 2.3e-13 Cystic fibrosis severity; CRC cis rs501120 0.584 rs617019 chr10:44737246 A/G cg09554077 chr10:44749378 NA -0.7 -7.83 -0.4 6.87e-14 Coronary artery disease;Coronary heart disease; CRC cis rs11155671 0.530 rs9397420 chr6:150206781 C/T cg13206674 chr6:150067644 NUP43 -0.48 -6.99 -0.36 1.52e-11 Testicular germ cell tumor; CRC cis rs4665809 0.590 rs1865324 chr2:26417533 C/A cg08067268 chr2:26466485 HADHB;HADHA -0.66 -8.45 -0.42 9.58e-16 Gut microbiome composition (summer); CRC cis rs10905065 0.965 rs10752110 chr10:5837038 T/C cg25171089 chr10:5708825 ASB13 0.41 5.75 0.3 2.04e-8 Menopause (age at onset); CRC cis rs6952808 0.825 rs34922657 chr7:1938655 C/T cg21782813 chr7:2030301 MAD1L1 0.46 7.76 0.39 1.08e-13 Bipolar disorder and schizophrenia; CRC cis rs12477438 0.501 rs11683107 chr2:99759235 T/A cg14399236 chr2:99771627 LIPT1;TSGA10 0.73 12.36 0.56 4.4e-29 Chronic sinus infection; CRC cis rs801193 0.569 rs6951302 chr7:66132512 T/C cg11764359 chr7:65958608 NA -0.59 -8.69 -0.43 1.7e-16 Aortic root size; CRC cis rs1799949 0.965 rs8176087 chr17:41270666 C/A cg25072359 chr17:41440525 NA 0.43 6.34 0.33 7.37e-10 Menopause (age at onset); CRC cis rs2288073 0.965 rs10173173 chr2:24415461 G/T cg06627628 chr2:24431161 ITSN2 0.69 9.61 0.47 1.9e-19 Venous thromboembolism (SNP x SNP interaction); CRC cis rs28374715 0.532 rs28477406 chr15:41642036 C/G cg18705301 chr15:41695430 NDUFAF1 -1.12 -18.23 -0.71 8.31e-52 Ulcerative colitis; CRC cis rs1008375 0.932 rs11935124 chr4:17668200 G/A cg16339924 chr4:17578868 LAP3 -0.51 -6.34 -0.33 7.51e-10 Parasitemia in Tripanosoma cruzi seropositivity; CRC trans rs4650994 1.000 rs10913570 chr1:178523126 A/C cg05059571 chr16:84539110 KIAA1609 -0.45 -6.84 -0.35 3.91e-11 HDL cholesterol levels;HDL cholesterol; CRC cis rs4964805 0.657 rs4964813 chr12:104189554 T/C cg02344784 chr12:104178138 NT5DC3 0.79 14.97 0.64 5.11e-39 Attention deficit hyperactivity disorder; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg02852436 chr20:2821472 FAM113A;VPS16 0.37 5.97 0.31 6.04e-9 Liver disease severity in Alagille syndrome; CRC cis rs4836694 0.574 rs3780712 chr9:132943082 A/G cg13414629 chr9:132935646 FREQ 0.44 6.35 0.33 7.06e-10 Alzheimer's disease (cognitive decline); CRC cis rs2944591 0.505 rs747462 chr2:233790171 A/C cg11972305 chr2:233791962 NGEF -0.39 -6.03 -0.32 4.41e-9 Autism spectrum disorder or schizophrenia; CRC cis rs11758351 0.660 rs1997768 chr6:26217728 C/T cg22723502 chr6:26240528 HIST1H4F 0.36 5.99 0.31 5.43e-9 Gout;Renal underexcretion gout; CRC cis rs2227564 0.794 rs2633320 chr10:75693306 A/G cg00564723 chr10:75632066 CAMK2G -0.28 -6.54 -0.34 2.39e-10 Crohn's disease;Inflammatory bowel disease; CRC cis rs2294693 0.947 rs742492 chr6:40996381 G/A cg14769373 chr6:40998127 UNC5CL -0.56 -7.46 -0.38 7.65e-13 Gastric cancer;Non-cardia gastric cancer; CRC cis rs10493773 0.618 rs34746573 chr1:86075360 G/A cg17807903 chr1:86174739 ZNHIT6 -0.45 -8.2 -0.41 5.37e-15 Urate levels in overweight individuals; CRC cis rs6120849 0.754 rs6120788 chr20:33583716 C/T cg08999081 chr20:33150536 PIGU 0.46 5.8 0.3 1.58e-8 Protein C levels; CRC cis rs17001868 0.568 rs9611328 chr22:40791972 C/T cg07138101 chr22:40742427 ADSL 0.54 7.14 0.37 6.03e-12 Mammographic density (dense area); CRC cis rs798554 0.959 rs798528 chr7:2772431 A/C cg13628971 chr7:2884303 GNA12 0.54 7.32 0.37 1.93e-12 Height; CRC cis rs6933660 0.721 rs2128945 chr6:151767907 A/G cg14416726 chr6:151773293 C6orf211;RMND1 -0.64 -9.68 -0.47 1.18e-19 Menarche (age at onset); CRC cis rs67311347 1.000 rs6801859 chr3:40493218 G/T cg09455208 chr3:40491958 NA -0.39 -8.05 -0.41 1.53e-14 Renal cell carcinoma; CRC cis rs2455601 0.882 rs11042116 chr11:8928472 G/C cg09997546 chr11:8931473 C11orf17;ST5 -0.51 -6.72 -0.35 8.25e-11 Schizophrenia; CRC cis rs6752107 0.967 rs11694081 chr2:234148586 A/T cg07618928 chr2:234183455 ATG16L1;SCARNA5 0.56 8.9 0.44 3.77e-17 Crohn's disease;Inflammatory bowel disease; CRC cis rs7772486 0.754 rs702324 chr6:146008793 A/G cg23711669 chr6:146136114 FBXO30 -0.7 -10.98 -0.52 4.09e-24 Lobe attachment (rater-scored or self-reported); CRC cis rs6933660 0.745 rs3800272 chr6:151744283 A/G cg17179660 chr6:151773299 C6orf211;RMND1 0.38 5.69 0.3 2.79e-8 Menarche (age at onset); CRC cis rs11098499 0.779 rs7674500 chr4:120303593 C/T cg09307838 chr4:120376055 NA 0.71 10.93 0.52 6.41e-24 Corneal astigmatism; CRC cis rs10464366 0.544 rs12668821 chr7:39167846 T/A cg20302533 chr7:39170763 POU6F2 0.42 5.7 0.3 2.74e-8 IgG glycosylation; CRC cis rs6912958 0.516 rs242278 chr6:88047059 C/T cg04972856 chr6:88032051 C6orf162;GJB7 0.31 5.94 0.31 7.07e-9 Monocyte percentage of white cells; CRC cis rs9393692 0.620 rs9358918 chr6:26286744 C/T cg00631329 chr6:26305371 NA -0.53 -9.1 -0.45 8.92e-18 Educational attainment; CRC cis rs6952808 0.825 rs4236277 chr7:1942270 C/T cg20295408 chr7:1910781 MAD1L1 -0.42 -5.98 -0.31 5.97e-9 Bipolar disorder and schizophrenia; CRC cis rs478304 0.934 rs537786 chr11:65494987 C/T cg08755490 chr11:65554678 OVOL1 0.4 5.85 0.31 1.19e-8 Acne (severe); CRC cis rs7769051 0.522 rs6934190 chr6:133116664 G/A cg07930552 chr6:133119739 C6orf192 0.87 7.24 0.37 3.25e-12 Type 2 diabetes nephropathy; CRC cis rs1223397 0.651 rs2458314 chr6:13309224 C/T cg00460589 chr6:13274354 PHACTR1 0.38 6.08 0.32 3.26e-9 Blood pressure; CRC cis rs11098499 0.863 rs7678400 chr4:120461957 G/A cg09307838 chr4:120376055 NA 0.67 10.34 0.5 6.89e-22 Corneal astigmatism; CRC cis rs17253792 0.822 rs12323476 chr14:56172722 C/T cg01858014 chr14:56050164 KTN1 0.6 6.17 0.32 2.03e-9 Putamen volume; CRC cis rs9325144 0.510 rs6582599 chr12:38715965 T/G cg13010199 chr12:38710504 ALG10B 0.43 6.26 0.33 1.19e-9 Morning vs. evening chronotype; CRC cis rs3749237 0.595 rs35701831 chr3:49515000 A/C cg02487422 chr3:49467188 NICN1 0.43 6.96 0.36 1.86e-11 Resting heart rate; CRC cis rs7224685 0.501 rs781827 chr17:3962965 G/A cg10724054 chr17:3904396 NA -0.47 -7.96 -0.4 2.75e-14 Type 2 diabetes; CRC trans rs12478296 0.818 rs57194240 chr2:243011545 A/G cg18288967 chr1:45987694 PRDX1 0.6 7.0 0.36 1.46e-11 Obesity-related traits; CRC cis rs12995491 0.731 rs17435439 chr2:88511391 A/G cg04511125 chr2:88470314 THNSL2 -0.4 -5.83 -0.31 1.29e-8 Response to metformin (IC50); CRC cis rs6743376 0.556 rs2515401 chr2:113820476 C/T cg24553058 chr2:113831203 IL1F10 -0.42 -6.89 -0.35 2.92e-11 Inflammatory biomarkers; CRC cis rs709400 0.628 rs12879085 chr14:103874420 G/A cg12935359 chr14:103987150 CKB 0.52 8.46 0.42 8.72e-16 Body mass index; CRC cis rs7589728 0.858 rs1914734 chr2:88529509 T/C cg18490616 chr2:88469792 THNSL2 0.5 5.66 0.3 3.24e-8 Plasma clusterin levels; CRC cis rs7726839 0.540 rs7434 chr5:660804 A/G cg16447950 chr5:562315 NA 0.78 10.6 0.5 9.08e-23 Obesity-related traits; CRC cis rs17711722 0.528 rs73138179 chr7:65294482 G/T cg02869306 chr7:64672164 INTS4L1 -0.43 -6.9 -0.36 2.69e-11 Calcium levels; CRC cis rs5753618 0.561 rs1858821 chr22:31676454 T/C cg22777020 chr22:31556080 RNF185 -0.51 -5.82 -0.31 1.42e-8 Colorectal cancer; CRC cis rs1448094 0.817 rs12370270 chr12:86343303 T/G cg00310523 chr12:86230176 RASSF9 0.43 7.22 0.37 3.68e-12 Major depressive disorder; CRC cis rs10751667 0.666 rs10794347 chr11:939863 G/A cg23136738 chr11:925521 AP2A2 -0.42 -6.98 -0.36 1.65e-11 Alzheimer's disease (late onset); CRC cis rs7552404 0.727 rs2172508 chr1:76320215 A/G cg22875332 chr1:76189707 ACADM 0.56 7.12 0.37 6.82e-12 Blood metabolite levels;Acylcarnitine levels; CRC cis rs524281 0.861 rs7929909 chr11:65951698 C/T cg14036092 chr11:66035641 RAB1B -0.47 -5.71 -0.3 2.54e-8 Electroencephalogram traits; CRC cis rs7255436 0.931 rs7249520 chr19:8446056 G/A cg16745616 chr19:8428856 ANGPTL4 -0.44 -6.94 -0.36 2.04e-11 HDL cholesterol; CRC cis rs9811920 0.638 rs793440 chr3:99643176 C/T cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G 0.45 6.1 0.32 3.04e-9 Axial length; CRC cis rs7647973 0.626 rs62260720 chr3:49853796 T/A cg03060546 chr3:49711283 APEH -0.66 -8.02 -0.4 1.89e-14 Menarche (age at onset); CRC cis rs9488822 0.676 rs13194714 chr6:116394819 T/A cg15226275 chr6:116381976 FRK 0.3 8.43 0.42 1.08e-15 Cholesterol, total;LDL cholesterol; CRC cis rs3093024 0.874 rs3093018 chr6:167539805 C/T cg05540913 chr6:167530185 CCR6 -0.35 -6.41 -0.33 5.17e-10 Rheumatoid arthritis; CRC cis rs7932354 0.528 rs2018527 chr11:47175809 A/G cg03339077 chr11:47165057 C11orf49 -0.48 -6.8 -0.35 5.08e-11 Bone mineral density (hip);Bone mineral density; CRC cis rs1997103 0.863 rs4480062 chr7:55401299 T/C cg17469321 chr7:55412551 NA 0.73 11.31 0.53 2.87e-25 QRS interval (sulfonylurea treatment interaction); CRC cis rs56114371 0.777 rs200481 chr6:27773832 A/T cg03623178 chr6:28175578 NA 0.7 6.28 0.33 1.08e-9 Breast cancer; CRC cis rs736801 0.836 rs2522052 chr5:131798487 C/T cg14196790 chr5:131705035 SLC22A5 -0.35 -5.62 -0.3 3.98e-8 Breast cancer;Mosquito bite size; CRC trans rs116095464 0.614 rs78905930 chr5:246560 G/A cg00938859 chr5:1591904 SDHAP3 0.73 7.76 0.39 1.05e-13 Breast cancer; CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg17157516 chr1:35332203 DLGAP3 -0.52 -6.45 -0.34 3.96e-10 Diisocyanate-induced asthma; CRC cis rs172166 0.694 rs203892 chr6:28067196 T/C cg26587870 chr6:27730563 NA -0.37 -5.64 -0.3 3.62e-8 Cardiac Troponin-T levels; CRC cis rs9811920 0.638 rs793461 chr3:99615758 C/T cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G 0.46 6.18 0.32 1.87e-9 Axial length; CRC cis rs644799 1.000 rs509720 chr11:95562771 T/C cg25478527 chr11:95522999 CEP57;FAM76B 0.52 7.86 0.4 5.6e-14 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs875971 0.545 rs13311962 chr7:66068129 C/T cg18876405 chr7:65276391 NA -0.46 -6.33 -0.33 8.06e-10 Aortic root size; CRC cis rs4790333 0.813 rs2005029 chr17:2255138 G/T cg02569219 chr17:2266849 SGSM2 -0.52 -9.04 -0.45 1.37e-17 Proinsulin levels; CRC cis rs4862750 0.872 rs11947595 chr4:187899827 C/T cg03452623 chr4:187889614 NA -0.92 -22.45 -0.78 2.37e-68 Lobe attachment (rater-scored or self-reported); CRC cis rs9462846 0.841 rs13206802 chr6:42871148 G/A cg21280719 chr6:42927975 GNMT -0.33 -6.47 -0.34 3.65e-10 Blood protein levels; CRC cis rs9303401 0.659 rs72828726 chr17:56951217 C/G cg10487724 chr17:56770010 TEX14;RAD51C 0.76 9.44 0.46 6.89e-19 Cognitive test performance; CRC cis rs2112347 0.502 rs34339 chr5:74931333 G/T cg19683494 chr5:74908142 NA -0.54 -5.88 -0.31 9.87e-9 Body mass index (joint analysis main effects and smoking interaction);Waist circumference;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Hip circumference;Body mass index;Body mass index in physically active individuals;Obesity; CRC cis rs4862750 0.872 rs6811837 chr4:187898162 G/A cg27532560 chr4:187881888 NA -0.56 -10.22 -0.49 1.79e-21 Lobe attachment (rater-scored or self-reported); CRC cis rs10782582 0.593 rs6664254 chr1:76235084 G/T cg10523679 chr1:76189770 ACADM -0.44 -6.18 -0.32 1.9e-9 Daytime sleep phenotypes; CRC cis rs4665809 1.000 rs4665308 chr2:26330514 C/A cg04944784 chr2:26401820 FAM59B -0.6 -7.67 -0.39 1.98e-13 Gut microbiome composition (summer); CRC cis rs9648716 0.580 rs801098 chr7:140655727 A/G cg10747023 chr7:140774559 NA 0.42 5.79 0.3 1.67e-8 Type 2 diabetes; CRC cis rs10486722 0.624 rs10224857 chr7:41765978 T/G cg22138096 chr7:41772439 LOC285954 0.38 5.64 0.3 3.57e-8 Pit-and-Fissure caries; CRC cis rs611744 0.647 rs587340 chr8:109246032 C/A cg21045802 chr8:109455806 TTC35 0.42 6.64 0.34 1.3100000000000001e-10 Dupuytren's disease; CRC cis rs7666738 0.830 rs4699603 chr4:99056172 T/C cg05340658 chr4:99064831 C4orf37 0.6 9.31 0.46 1.85e-18 Colonoscopy-negative controls vs population controls; CRC cis rs12200560 0.505 rs4240555 chr6:97076274 T/C cg06623918 chr6:96969491 KIAA0776 0.52 7.76 0.39 1.08e-13 Coronary heart disease; CRC cis rs6912958 0.559 rs242279 chr6:88048191 A/G cg04972856 chr6:88032051 C6orf162;GJB7 0.31 5.92 0.31 8.07e-9 Monocyte percentage of white cells; CRC cis rs7129556 1.000 rs7129556 chr11:77300048 A/G cg12586386 chr11:77299805 AQP11 -0.42 -5.89 -0.31 9.66e-9 Weight loss (gastric bypass surgery); CRC cis rs868943 0.743 rs13192924 chr6:116352332 T/C cg15226275 chr6:116381976 FRK 0.31 7.36 0.38 1.45e-12 Total cholesterol levels; CRC cis rs4713118 0.513 rs149962 chr6:28015918 G/A cg10876282 chr6:28092338 ZSCAN16 0.48 6.55 0.34 2.21e-10 Parkinson's disease; CRC cis rs6541297 1.000 rs6541297 chr1:230283506 G/A cg05784532 chr1:230284198 GALNT2 0.42 5.87 0.31 1.08e-8 Coronary artery disease; CRC cis rs4076764 0.958 rs11584957 chr1:163392937 C/T cg24596788 chr1:163392923 NA -0.68 -10.91 -0.52 7.49e-24 Motion sickness; CRC cis rs1223397 0.938 rs35511719 chr6:13282442 T/C cg20827128 chr6:13274284 PHACTR1 0.55 6.55 0.34 2.27e-10 Blood pressure; CRC cis rs1697139 0.604 rs874550 chr5:66530945 C/T cg16691251 chr5:66510806 NA -0.44 -7.88 -0.4 4.84e-14 Breast cancer; CRC cis rs875971 1.000 rs4717300 chr7:65947380 T/C cg11764359 chr7:65958608 NA 0.63 10.13 0.49 3.68e-21 Aortic root size; CRC cis rs2153535 0.580 rs9393033 chr6:8521446 G/A cg21535247 chr6:8435926 SLC35B3 0.47 7.33 0.37 1.83e-12 Motion sickness; CRC cis rs7666738 0.830 rs11947578 chr4:98930462 T/G cg05340658 chr4:99064831 C4orf37 0.6 9.35 0.46 1.41e-18 Colonoscopy-negative controls vs population controls; CRC cis rs40363 0.645 rs1690447 chr16:3519211 T/C cg05754148 chr16:3507555 NAT15 0.54 7.36 0.38 1.44e-12 Tuberculosis; CRC cis rs947211 0.950 rs885224 chr1:205753097 A/G cg11965913 chr1:205819406 PM20D1 0.46 6.42 0.33 4.79e-10 Parkinson's disease; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg08300164 chr4:56815263 CEP135 0.48 6.64 0.34 1.29e-10 Response to antipsychotic treatment; CRC cis rs372883 0.600 rs2832298 chr21:30743863 C/G cg24692254 chr21:30365293 RNF160 0.63 9.72 0.47 8.42e-20 Pancreatic cancer; CRC cis rs13315871 1.000 rs36037390 chr3:58321954 C/T cg20936604 chr3:58311152 NA -0.76 -7.27 -0.37 2.69e-12 Cholesterol, total; CRC cis rs10751667 0.666 rs4074233 chr11:977685 G/A cg23136738 chr11:925521 AP2A2 -0.42 -7.09 -0.36 8.19e-12 Alzheimer's disease (late onset); CRC cis rs2839186 0.500 rs13049893 chr21:47707054 C/T cg00612595 chr21:47717864 NA -0.39 -6.25 -0.33 1.28e-9 Testicular germ cell tumor; CRC trans rs1728785 1.000 rs1728801 chr16:68571457 A/C cg04657470 chr2:198365150 HSPE1;HSPD1 0.58 6.97 0.36 1.72e-11 Ulcerative colitis; CRC cis rs7527798 0.592 rs4097398 chr1:207857760 C/T cg09232269 chr1:207846808 CR1L -0.45 -7.33 -0.37 1.84e-12 Erythrocyte sedimentation rate; CRC cis rs6502050 0.764 rs7215277 chr17:80159283 C/A cg22110888 chr17:80059540 CCDC57 0.38 6.07 0.32 3.61e-9 Life satisfaction; CRC cis rs7914558 1.000 rs11191541 chr10:104824199 A/G cg15744005 chr10:104629667 AS3MT -0.33 -7.06 -0.36 9.89e-12 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs9462027 0.628 rs7739771 chr6:34779801 C/A cg07306190 chr6:34760872 UHRF1BP1 -0.34 -5.95 -0.31 6.95e-9 Systemic lupus erythematosus; CRC trans rs4879656 0.525 rs10971406 chr9:33099668 A/G cg22174844 chr1:39570747 MACF1 -0.46 -6.28 -0.33 1.06e-9 Menopause (age at onset); CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg03193417 chr12:56583536 SMARCC2 0.49 6.19 0.32 1.83e-9 Thyroid stimulating hormone; CRC cis rs2976388 0.590 rs13254346 chr8:143823863 G/C cg04969067 chr8:143858791 LYNX1 -0.42 -6.64 -0.34 1.28e-10 Urinary tract infection frequency; CRC cis rs9916302 0.851 rs6503502 chr17:37501855 A/G cg07936489 chr17:37558343 FBXL20 0.79 11.88 0.55 2.48e-27 Glomerular filtration rate (creatinine); CRC cis rs853679 0.517 rs9393891 chr6:28079160 C/T cg12172441 chr6:28176163 NA 0.62 7.27 0.37 2.56e-12 Depression; CRC cis rs8177253 0.896 rs34252038 chr3:133490621 G/T cg08048268 chr3:133502702 NA -0.39 -7.37 -0.38 1.37e-12 Iron status biomarkers; CRC cis rs11792861 0.926 rs118011482 chr9:111770626 G/C cg05043794 chr9:111880884 C9orf5 -0.34 -5.96 -0.31 6.56e-9 Menarche (age at onset); CRC cis rs4481887 1.000 rs4916128 chr1:248466706 G/A cg00666640 chr1:248458726 OR2T12 0.52 9.22 0.45 3.57e-18 Common traits (Other); CRC cis rs995000 0.965 rs4587594 chr1:63133930 G/A cg19896129 chr1:63156450 NA 0.4 5.94 0.31 7.29e-9 Triglyceride levels; CRC cis rs2976388 0.609 rs2717603 chr8:143803193 T/C cg04969067 chr8:143858791 LYNX1 0.44 7.47 0.38 7.38e-13 Urinary tract infection frequency; CRC cis rs769267 0.965 rs2905425 chr19:19475717 G/C cg02546618 chr19:19431379 KIAA0892;SF4 -0.47 -6.45 -0.34 3.9e-10 Tonsillectomy; CRC cis rs11583043 0.874 rs6577219 chr1:101415707 A/G cg00063077 chr1:101360652 SLC30A7;EXTL2 0.48 6.48 0.34 3.35e-10 Ulcerative colitis;Inflammatory bowel disease; CRC cis rs853679 0.517 rs9380061 chr6:28132803 T/C cg02683197 chr6:28174875 NA 0.87 10.73 0.51 3.25e-23 Depression; CRC cis rs12900413 0.687 rs12906905 chr15:90315399 A/G cg24249390 chr15:90295951 MESP1 -0.59 -9.61 -0.47 1.93e-19 Coronary artery aneurysm in Kawasaki disease; CRC cis rs11190604 1.000 rs10883492 chr10:102206089 G/A cg16342193 chr10:102329863 NA -0.35 -5.83 -0.31 1.29e-8 Palmitoleic acid (16:1n-7) levels; CRC cis rs9660180 0.620 rs34298494 chr1:1663402 A/C cg23982607 chr1:1823379 GNB1 0.41 5.78 0.3 1.72e-8 Body mass index; CRC cis rs17253792 0.598 rs35830444 chr14:56017350 T/C cg01858014 chr14:56050164 KTN1 -0.86 -6.64 -0.34 1.27e-10 Putamen volume; CRC trans rs7690467 0.794 rs1875024 chr4:133395895 C/T cg19296258 chr17:78878799 RPTOR -0.49 -6.61 -0.34 1.51e-10 Eating disorders; CRC cis rs1707322 0.752 rs7541962 chr1:46235117 G/A cg03146154 chr1:46216737 IPP 0.66 9.42 0.46 8.32e-19 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs7487075 0.619 rs2408498 chr12:46796900 G/A cg22049899 chr12:47219821 SLC38A4 0.32 5.88 0.31 9.88e-9 Itch intensity from mosquito bite; CRC cis rs6502050 0.835 rs3935403 chr17:80114145 C/T cg19223190 chr17:80058835 NA 0.38 6.18 0.32 1.94e-9 Life satisfaction; CRC cis rs4665809 1.000 rs12471809 chr2:26307140 A/G cg26119090 chr2:26468346 HADHA;HADHB -0.62 -7.88 -0.4 4.76e-14 Gut microbiome composition (summer); CRC cis rs9534288 0.956 rs962694 chr13:46619026 T/C cg15192986 chr13:46630673 CPB2 -0.74 -10.36 -0.5 5.94e-22 Blood protein levels; CRC cis rs172166 0.637 rs1233691 chr6:28153897 T/G cg10876282 chr6:28092338 ZSCAN16 0.49 6.71 0.35 8.48e-11 Cardiac Troponin-T levels; CRC cis rs6499255 1.000 rs73579497 chr16:69824150 C/G cg04110750 chr16:69646130 NFAT5 -0.52 -6.92 -0.36 2.3e-11 IgE levels; CRC cis rs72781680 1.000 rs72781649 chr2:24210864 A/G cg08917208 chr2:24149416 ATAD2B 0.9 9.13 0.45 6.93e-18 Lymphocyte counts; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg12570787 chr5:219185 SDHA;CCDC127 0.4 6.07 0.32 3.5e-9 Liver disease severity in Alagille syndrome; CRC cis rs4731207 0.698 rs6466954 chr7:124515346 T/C cg23710748 chr7:124431027 NA -0.38 -6.08 -0.32 3.42e-9 Cutaneous malignant melanoma; CRC cis rs7927771 0.524 rs9633830 chr11:47849470 T/G cg20307385 chr11:47447363 PSMC3 0.45 6.62 0.34 1.48e-10 Subjective well-being; CRC cis rs10504229 1.000 rs74546828 chr8:58171678 A/G cg05313129 chr8:58192883 C8orf71 -0.47 -6.99 -0.36 1.49e-11 Developmental language disorder (linguistic errors); CRC cis rs4638749 0.734 rs6542756 chr2:108865629 C/G cg25838818 chr2:108905173 SULT1C2 -0.34 -5.78 -0.3 1.71e-8 Blood pressure; CRC cis rs2404602 0.684 rs10851888 chr15:76902506 C/T cg03037974 chr15:76606532 NA -0.5 -7.1 -0.36 7.9e-12 Blood metabolite levels; CRC cis rs977987 0.806 rs7202596 chr16:75491072 G/T cg03315344 chr16:75512273 CHST6 0.56 9.51 0.46 4.26e-19 Dupuytren's disease; CRC cis rs5769765 0.908 rs4074304 chr22:50309446 G/A cg02269571 chr22:50332266 NA -0.58 -7.57 -0.39 3.69e-13 Schizophrenia; CRC cis rs6460942 0.915 rs62448619 chr7:12457743 C/T cg20607287 chr7:12443886 VWDE -0.66 -6.93 -0.36 2.17e-11 Coronary artery disease; CRC cis rs995000 0.931 rs1168015 chr1:62996046 C/G cg19896129 chr1:63156450 NA -0.45 -6.97 -0.36 1.75e-11 Triglyceride levels; CRC trans rs1814175 0.817 rs7924619 chr11:49620632 G/A cg15704280 chr7:45808275 SEPT13 -0.98 -18.83 -0.72 3.41e-54 Height; CRC cis rs4665809 0.887 rs28699126 chr2:26357294 C/T cg04944784 chr2:26401820 FAM59B -0.61 -8.05 -0.41 1.57e-14 Gut microbiome composition (summer); CRC cis rs806215 0.906 rs806195 chr7:127249178 A/G cg25922125 chr7:127225783 GCC1 0.58 6.37 0.33 6.52e-10 Type 2 diabetes; CRC cis rs7811142 1.000 rs73161759 chr7:100009994 T/C cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.18 17.67 0.7 1.31e-49 Platelet count; CRC trans rs11098499 0.954 rs10008392 chr4:120318839 G/A cg25214090 chr10:38739885 LOC399744 0.65 10.24 0.49 1.56e-21 Corneal astigmatism; CRC cis rs40363 0.723 rs4785936 chr16:3535116 A/G cg21433313 chr16:3507492 NAT15 -0.6 -6.09 -0.32 3.2e-9 Tuberculosis; CRC trans rs1455244 0.700 rs7229302 chr18:11508904 G/T cg18088653 chr15:71407757 CT62 0.39 6.15 0.32 2.19e-9 Schizophrenia; CRC cis rs3771570 0.901 rs56129392 chr2:242242439 C/T cg21155796 chr2:242212141 HDLBP 0.64 7.0 0.36 1.48e-11 Prostate cancer; CRC cis rs3096299 0.685 rs4785571 chr16:89565169 A/G cg00750074 chr16:89608354 SPG7 -0.44 -6.7 -0.35 9.29e-11 Multiple myeloma (IgH translocation); CRC cis rs4862750 0.914 rs6837117 chr4:187872379 C/T cg22105103 chr4:187893119 NA 0.63 11.4 0.53 1.32e-25 Lobe attachment (rater-scored or self-reported); CRC cis rs12711979 0.509 rs10195488 chr2:3824135 T/C cg17052675 chr2:3827356 NA -0.86 -21.11 -0.76 3.77e-63 Itch intensity from mosquito bite adjusted by bite size; CRC cis rs853679 0.517 rs9357065 chr6:28129580 T/C cg15786705 chr6:28176104 NA 0.78 9.63 0.47 1.65e-19 Depression; CRC cis rs9925964 0.933 rs9929899 chr16:31062701 C/A cg03418659 chr16:31128414 MYST1 0.46 6.83 0.35 4.23e-11 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs644799 0.710 rs523153 chr11:95570961 G/A cg25478527 chr11:95522999 CEP57;FAM76B 0.48 7.39 0.38 1.24e-12 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs644799 0.562 rs654345 chr11:95581865 T/C cg25622487 chr11:95524042 FAM76B;CEP57 0.57 8.53 0.43 5.53e-16 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs995000 0.931 rs2479464 chr1:63130991 G/A cg19896129 chr1:63156450 NA -0.42 -6.45 -0.34 3.99e-10 Triglyceride levels; CRC cis rs7932354 0.528 rs7103581 chr11:47072805 G/T cg03339077 chr11:47165057 C11orf49 0.44 6.23 0.32 1.44e-9 Bone mineral density (hip);Bone mineral density; CRC trans rs2303319 0.504 rs62187609 chr2:162431500 C/T cg12500891 chr11:57225987 NA -0.69 -6.06 -0.32 3.82e-9 Cognitive function; CRC cis rs9381040 0.674 rs3747742 chr6:41162518 C/T cg09580153 chr6:41068724 NFYA;LOC221442 0.52 7.51 0.38 5.64e-13 Alzheimer's disease (late onset); CRC cis rs295137 0.752 rs10931892 chr2:201104997 C/T cg23649088 chr2:200775458 C2orf69 -0.4 -5.77 -0.3 1.85e-8 Asthma (bronchodilator response); CRC cis rs1707322 0.785 rs10890348 chr1:46242423 G/T cg06784218 chr1:46089804 CCDC17 0.61 11.04 0.52 2.48e-24 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg19590290 chr4:104119639 CENPE 0.44 6.17 0.32 2.03e-9 Anxiety disorder; CRC trans rs877282 0.947 rs7904978 chr10:768078 C/T cg22713356 chr15:30763199 NA 1.33 16.07 0.66 2.6e-43 Uric acid levels; CRC cis rs2739330 0.796 rs1006771 chr22:24314006 G/T cg10150615 chr22:24372951 LOC391322 -0.59 -9.06 -0.45 1.17e-17 Liver enzyme levels (gamma-glutamyl transferase); CRC trans rs11148252 0.740 rs9596648 chr13:52934569 A/T cg18335740 chr13:41363409 SLC25A15 -0.52 -7.78 -0.39 9.41e-14 Lewy body disease; CRC cis rs172166 0.694 rs203876 chr6:28046673 T/C cg21251018 chr6:28226885 NKAPL 0.46 7.14 0.37 6.07e-12 Cardiac Troponin-T levels; CRC cis rs77633900 0.772 rs157768 chr15:76833779 C/T cg21673338 chr15:77095150 SCAPER -0.78 -7.42 -0.38 9.94e-13 Non-glioblastoma glioma;Glioma; CRC cis rs72627123 0.867 rs73301477 chr14:74463560 C/T cg12022184 chr14:74485813 ENTPD5;C14orf45 0.72 6.0 0.31 5.3300000000000004e-09 Morning vs. evening chronotype; CRC cis rs853679 0.517 rs9295761 chr6:28147987 A/G cg23161317 chr6:28129485 ZNF389 0.54 6.52 0.34 2.61e-10 Depression; CRC cis rs3736594 0.546 rs7571558 chr2:27839832 C/G cg27432699 chr2:27873401 GPN1 0.61 8.05 0.41 1.53e-14 Fasting blood glucose;Fasting blood glucose (BMI interaction); CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg00402069 chr5:89770788 POLR3G;MBLAC2 0.42 6.53 0.34 2.46e-10 Obesity-related traits; CRC cis rs2456568 0.900 rs2456559 chr11:93668858 A/T cg26875233 chr11:93583750 C11orf90 -0.33 -6.48 -0.34 3.36e-10 Response to serotonin reuptake inhibitors in major depressive disorder; CRC cis rs10791097 0.765 rs10894269 chr11:130722789 C/T cg12179176 chr11:130786555 SNX19 0.72 11.15 0.52 1.02e-24 Autism spectrum disorder or schizophrenia;Schizophrenia; CRC trans rs35110281 0.782 rs6518302 chr21:45018478 A/G cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.51 8.59 0.43 3.61e-16 Mean corpuscular volume; CRC trans rs473651 0.837 rs563458 chr2:239345613 T/A cg13521940 chr21:36262239 RUNX1 -0.4 -5.97 -0.31 6.29e-9 Multiple system atrophy; CRC cis rs514406 0.861 rs2448792 chr1:53268313 T/C cg08859206 chr1:53392774 SCP2 0.45 6.94 0.36 2.08e-11 Monocyte count; CRC cis rs6604026 0.740 rs10874747 chr1:93352491 A/G cg17283838 chr1:93427260 FAM69A -0.5 -6.89 -0.35 2.9e-11 Multiple sclerosis; CRC cis rs2404602 0.622 rs2003344 chr15:76632301 T/C cg03037974 chr15:76606532 NA -0.44 -6.19 -0.32 1.76e-9 Blood metabolite levels; CRC cis rs7762018 1.000 rs41265383 chr6:170068025 T/C cg17545662 chr6:170176663 C6orf70 0.53 5.82 0.31 1.39e-8 Thiazide-induced adverse metabolic effects in hypertensive patients; CRC cis rs769267 0.896 rs11882123 chr19:19386339 A/G cg01262667 chr19:19385393 TM6SF2 0.36 5.87 0.31 1.06e-8 Tonsillectomy; CRC cis rs863345 0.604 rs6699473 chr1:158495209 C/T cg12129480 chr1:158549410 OR10X1 -0.29 -5.95 -0.31 6.94e-9 Pneumococcal bacteremia; CRC cis rs7647973 0.621 rs3774800 chr3:49334768 A/G cg07636037 chr3:49044803 WDR6 -0.77 -11.18 -0.52 8.1e-25 Menarche (age at onset); CRC cis rs9326248 0.520 rs74830 chr11:117090558 C/T cg20608306 chr11:116969690 SIK3 -0.29 -5.82 -0.31 1.38e-8 Blood protein levels; CRC cis rs965469 1.000 rs6051712 chr20:3265029 T/A cg25506879 chr20:3388711 C20orf194 -0.38 -5.62 -0.3 4.11e-8 IFN-related cytopenia; CRC cis rs13108904 0.901 rs12509700 chr4:1296321 A/G cg21620606 chr4:1342894 KIAA1530 0.4 7.22 0.37 3.59e-12 Obesity-related traits; CRC cis rs68170813 0.559 rs3801963 chr7:106898036 C/T cg02696742 chr7:106810147 HBP1 -0.53 -6.01 -0.31 4.84e-9 Coronary artery disease; CRC trans rs3733585 0.781 rs4292328 chr4:9970962 C/T cg26043149 chr18:55253948 FECH -0.53 -8.2 -0.41 5.61e-15 Cleft plate (environmental tobacco smoke interaction); CRC cis rs7927771 0.524 rs11039392 chr11:47798753 A/G cg20307385 chr11:47447363 PSMC3 0.46 6.61 0.34 1.52e-10 Subjective well-being; CRC cis rs597539 0.652 rs604524 chr11:68629929 G/A cg04772025 chr11:68637568 NA 0.51 8.13 0.41 8.98e-15 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs4481887 0.927 rs4279879 chr1:248486475 A/G cg13385794 chr1:248469461 NA 0.38 6.66 0.34 1.14e-10 Common traits (Other); CRC cis rs7659604 1.000 rs6814995 chr4:122664963 A/T cg19748678 chr4:122722346 EXOSC9 -0.56 -8.76 -0.43 1.06e-16 Type 2 diabetes; CRC cis rs9443645 0.901 rs9448588 chr6:79590061 T/G cg11833968 chr6:79620685 NA -0.36 -6.26 -0.33 1.23e-9 Intelligence (multi-trait analysis); CRC cis rs2073300 0.536 rs6137947 chr20:23414630 C/A cg12062639 chr20:23401060 NAPB 0.84 7.67 0.39 2.02e-13 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs2949837 0.581 rs2965068 chr7:45974375 T/C cg23193639 chr7:45961078 IGFBP3 0.38 6.52 0.34 2.73e-10 Sitting height ratio; CRC cis rs6495367 1.000 rs13380104 chr15:79378821 C/T cg17916960 chr15:79447300 NA 0.42 6.74 0.35 7.19e-11 Spherical equivalent (joint analysis main effects and education interaction); CRC cis rs6951245 0.935 rs11763765 chr7:1060510 C/T cg07217954 chr7:1067459 C7orf50 0.55 5.73 0.3 2.26e-8 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg25752527 chr2:136499146 UBXN4 0.43 6.38 0.33 6.1e-10 Intelligence (multi-trait analysis); CRC cis rs1707322 0.964 rs7546237 chr1:46285610 A/C cg06784218 chr1:46089804 CCDC17 0.5 8.91 0.44 3.64e-17 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs9303280 0.773 rs12949100 chr17:38057189 G/A cg11212589 chr17:38028394 ZPBP2 0.42 7.55 0.38 4.22e-13 Self-reported allergy; CRC trans rs56052703 0.702 rs76893841 chr19:13432778 G/A cg07875759 chr21:43639080 ABCG1 -0.49 -6.08 -0.32 3.33e-9 Proteinuria and chronic kidney disease; CRC cis rs4713118 0.869 rs4713121 chr6:27722064 T/C cg12172441 chr6:28176163 NA 0.59 7.37 0.38 1.43e-12 Parkinson's disease; CRC cis rs10992471 0.729 rs1022844 chr9:95553464 A/T cg14631576 chr9:95140430 CENPP -0.33 -5.97 -0.31 6.26e-9 Visceral adipose tissue/subcutaneous adipose tissue ratio; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg18247177 chr17:7745472 KDM6B 0.42 6.02 0.31 4.77e-9 Response to antipsychotic treatment; CRC trans rs7613875 0.600 rs1061474 chr3:50144951 T/C cg21665057 chr3:196295764 WDR53;FBXO45 -0.44 -6.32 -0.33 8.67e-10 Body mass index; CRC cis rs10504073 0.669 rs341809 chr8:50042557 C/T cg00325661 chr8:49890786 NA 0.48 8.47 0.42 8.2e-16 Blood metabolite ratios; CRC cis rs10504229 0.683 rs55881798 chr8:58106406 T/C cg22535103 chr8:58192502 C8orf71 -0.7 -8.98 -0.44 2.21e-17 Developmental language disorder (linguistic errors); CRC cis rs6424115 0.830 rs3123554 chr1:24196401 C/T cg10978503 chr1:24200527 CNR2 -0.61 -11.25 -0.53 4.46e-25 Immature fraction of reticulocytes; CRC cis rs10883723 0.810 rs7092622 chr10:104249919 T/G cg04362960 chr10:104952993 NT5C2 -0.41 -5.7 -0.3 2.64e-8 Allergic disease (asthma, hay fever or eczema); CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg26790897 chr7:56147772 SUMF2 0.37 6.08 0.32 3.29e-9 Myopia (pathological); CRC trans rs8002861 0.846 rs56408817 chr13:44471983 A/G cg12856521 chr11:46389249 DGKZ -0.44 -6.98 -0.36 1.67e-11 Leprosy; CRC cis rs3750965 0.734 rs11604251 chr11:68820429 A/G cg06818126 chr11:68850279 TPCN2 0.43 5.85 0.31 1.18e-8 Hair color; CRC trans rs7615952 0.799 rs13315434 chr3:125641394 T/G cg07211511 chr3:129823064 LOC729375 -1.12 -19.3 -0.73 5.07e-56 Blood pressure (smoking interaction); CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg12557235 chr12:122242600 SETD1B;LOC338799 0.45 6.22 0.32 1.48e-9 Anxiety disorder; CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg23713156 chr17:80606235 WDR45L 0.38 6.05 0.32 3.84e-9 Obesity-related traits; CRC cis rs6933660 0.760 rs6904364 chr6:151754273 T/C cg14416726 chr6:151773293 C6orf211;RMND1 -0.53 -7.75 -0.39 1.16e-13 Menarche (age at onset); CRC cis rs13191362 0.935 rs116735807 chr6:163010615 A/G cg06582575 chr6:163149167 PACRG;PARK2 0.76 10.41 0.5 4.01e-22 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC trans rs9914544 0.545 rs9914914 chr17:18787780 G/A cg21372672 chr17:16614065 CCDC144A -0.39 -6.1 -0.32 2.93e-9 Educational attainment (years of education); CRC cis rs2120019 0.938 rs2304903 chr15:75315778 A/G cg11632617 chr15:75315747 PPCDC -0.56 -7.74 -0.39 1.23e-13 Blood trace element (Zn levels); CRC cis rs812925 0.519 rs1186706 chr2:61673394 G/T cg10580144 chr2:61372316 C2orf74 0.31 6.71 0.35 8.71e-11 Immature fraction of reticulocytes; CRC cis rs7727544 0.654 rs4705849 chr5:131559199 T/A cg18758796 chr5:131593413 PDLIM4 0.35 6.36 0.33 6.6e-10 Blood metabolite levels; CRC cis rs2011503 0.891 rs2965186 chr19:19497195 T/G cg11584989 chr19:19387371 SF4 -0.55 -6.36 -0.33 6.6e-10 Bipolar disorder; CRC cis rs7100689 0.784 rs1870142 chr10:82182296 G/A cg00277334 chr10:82204260 NA -0.46 -6.04 -0.32 4.13e-9 Post bronchodilator FEV1; CRC cis rs9311474 0.508 rs11714565 chr3:52606292 C/T cg05573699 chr3:52720067 GNL3;PBRM1 -0.43 -6.34 -0.33 7.56e-10 Electroencephalogram traits; CRC cis rs10992471 0.756 rs10992319 chr9:95127895 G/A cg14631576 chr9:95140430 CENPP -0.4 -7.42 -0.38 1.01e-12 Visceral adipose tissue/subcutaneous adipose tissue ratio; CRC cis rs1448094 0.817 rs73176252 chr12:86347649 T/A cg02569458 chr12:86230093 RASSF9 0.48 8.01 0.4 2.05e-14 Major depressive disorder; CRC cis rs6500395 0.962 rs9923371 chr16:48628015 C/T cg04672837 chr16:48644449 N4BP1 0.45 6.75 0.35 6.7e-11 Response to tocilizumab in rheumatoid arthritis; CRC cis rs9308731 0.505 rs10169613 chr2:111934977 C/T cg04202892 chr2:111875749 ACOXL 0.35 5.68 0.3 3.01e-8 Chronic lymphocytic leukemia; CRC cis rs1800978 0.925 rs2244278 chr9:107661129 C/A cg14313833 chr9:107666037 ABCA1 -0.58 -5.96 -0.31 6.33e-9 Coronary artery disease; CRC cis rs8177253 0.761 rs1830083 chr3:133508551 G/A cg01448562 chr3:133502909 NA -0.72 -13.08 -0.58 9.07e-32 Iron status biomarkers; CRC cis rs1355223 0.583 rs1396881 chr11:34870506 G/T cg11058730 chr11:34937778 PDHX;APIP 0.71 11.55 0.54 3.78e-26 Systemic lupus erythematosus and Systemic sclerosis; CRC cis rs9560113 0.919 rs11069896 chr13:112178887 C/T cg10483660 chr13:112241077 NA 0.36 5.82 0.31 1.39e-8 Menarche (age at onset); CRC cis rs999943 0.846 rs10947420 chr6:33611061 C/G cg14003231 chr6:33640908 ITPR3 0.88 15.8 0.66 3.14e-42 Obesity (extreme); CRC cis rs3859192 0.599 rs34933056 chr17:38162983 G/A cg17467752 chr17:38218738 THRA -0.5 -7.22 -0.37 3.55e-12 White blood cell count; CRC cis rs394563 0.934 rs384334 chr6:149796172 C/G cg16235748 chr6:149772707 ZC3H12D -0.37 -6.37 -0.33 6.52e-10 Dupuytren's disease; CRC cis rs826838 1.000 rs11183196 chr12:38685915 G/T cg13010199 chr12:38710504 ALG10B 0.48 6.28 0.33 1.04e-9 Heart rate; CRC cis rs60871478 0.947 rs62432862 chr7:807719 G/C cg04727924 chr7:799746 HEATR2 -0.44 -6.38 -0.33 6.11e-10 Cerebrospinal P-tau181p levels; CRC trans rs11098499 0.863 rs3822195 chr4:120471660 C/T cg25214090 chr10:38739885 LOC399744 0.65 10.21 0.49 1.9e-21 Corneal astigmatism; CRC cis rs9341808 0.628 rs9294172 chr6:80918561 G/A cg08355045 chr6:80787529 NA 0.38 6.4 0.33 5.43e-10 Sitting height ratio; CRC cis rs4862750 0.872 rs7679956 chr4:187900229 C/T cg27532560 chr4:187881888 NA -0.6 -11.3 -0.53 3.13e-25 Lobe attachment (rater-scored or self-reported); CRC cis rs738322 0.553 rs28718653 chr22:38570698 C/A cg25457927 chr22:38595422 NA -0.31 -5.91 -0.31 8.55e-9 Cutaneous nevi; CRC cis rs875971 0.929 rs34406470 chr7:65929956 A/G cg00343986 chr7:65444356 GUSB 0.44 6.34 0.33 7.54e-10 Aortic root size; CRC cis rs12477438 0.501 rs6542868 chr2:99782848 A/C cg26064155 chr2:99771622 LIPT1;TSGA10 0.77 13.13 0.59 5.79e-32 Chronic sinus infection; CRC cis rs2979489 0.891 rs7822839 chr8:30354453 A/G cg26383811 chr8:30366931 RBPMS 0.7 9.94 0.48 1.62e-20 Mean corpuscular hemoglobin;Plateletcrit;Neutrophil count;Granulocyte count;Sum basophil neutrophil counts;Mean corpuscular volume;Myeloid white cell count;Sum neutrophil eosinophil counts; CRC cis rs7804356 1.000 rs73069510 chr7:26877567 T/C cg03456212 chr7:26904342 SKAP2 -0.49 -5.62 -0.3 4.1e-8 Type 1 diabetes; CRC cis rs72781680 1.000 rs72796329 chr2:24141912 G/A cg08917208 chr2:24149416 ATAD2B 0.91 9.24 0.45 3.06e-18 Lymphocyte counts; CRC cis rs9549260 0.640 rs4943796 chr13:41196016 C/T cg21288729 chr13:41239152 FOXO1 0.42 6.59 0.34 1.8e-10 Red blood cell count; CRC cis rs4880487 0.888 rs35341304 chr10:1252526 T/C cg03183215 chr10:1252341 ADARB2 -0.3 -6.32 -0.33 8.35e-10 Migraine; CRC cis rs6500602 0.727 rs4786515 chr16:4578133 T/A cg08645402 chr16:4508243 NA 0.63 11.1 0.52 1.63e-24 Schizophrenia; CRC cis rs4862750 0.872 rs9997374 chr4:187877549 T/A cg11301795 chr4:187892539 NA -0.86 -19.5 -0.73 8.09e-57 Lobe attachment (rater-scored or self-reported); CRC cis rs4713118 0.513 rs149878 chr6:27878738 T/G cg12172441 chr6:28176163 NA 0.57 7.93 0.4 3.39e-14 Parkinson's disease; CRC cis rs7586879 0.593 rs11689543 chr2:25130440 A/T cg22495460 chr2:25135724 ADCY3 -0.87 -17.43 -0.69 1.16e-48 Body mass index; CRC cis rs13226913 0.643 rs7780273 chr7:7250449 A/C cg04827551 chr7:7268805 C1GALT1 -0.4 -6.08 -0.32 3.33e-9 Serum galactose-deficient IgA1 levels; CRC cis rs9649213 0.593 rs6963210 chr7:97944986 G/A cg21770322 chr7:97807741 LMTK2 0.51 8.32 0.42 2.38e-15 Prostate cancer (SNP x SNP interaction); CRC cis rs6502050 0.865 rs74480314 chr17:80117716 C/T cg09264619 chr17:80180166 NA -0.35 -5.93 -0.31 7.76e-9 Life satisfaction; CRC cis rs10504229 0.593 rs17192845 chr8:58053339 C/T cg02725872 chr8:58115012 NA -0.56 -7.63 -0.39 2.61e-13 Developmental language disorder (linguistic errors); CRC cis rs12824058 0.831 rs12300308 chr12:130813825 G/A cg24838063 chr12:130822603 PIWIL1 0.58 9.7 0.47 9.81e-20 Menopause (age at onset); CRC cis rs4665809 0.590 rs2289019 chr2:26420809 G/C cg08067268 chr2:26466485 HADHB;HADHA -0.66 -8.45 -0.42 9.58e-16 Gut microbiome composition (summer); CRC cis rs7614311 0.731 rs73130544 chr3:63868596 G/A cg22134162 chr3:63841271 THOC7 -0.58 -6.03 -0.32 4.43e-9 Lung function (FVC);Lung function (FEV1); CRC trans rs1005277 0.579 rs1740745 chr10:38520056 T/C cg23533926 chr12:111358616 MYL2 -0.56 -8.67 -0.43 2e-16 Extrinsic epigenetic age acceleration; CRC cis rs875971 0.660 rs7807944 chr7:66087195 C/G cg25985355 chr7:65971099 NA 0.32 5.69 0.3 2.81e-8 Aortic root size; CRC cis rs6674176 0.660 rs6801 chr1:44396646 C/G cg13606994 chr1:44402422 ARTN 0.37 6.23 0.32 1.45e-9 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Cognitive ability; CRC cis rs9447004 0.584 rs56093139 chr6:74432923 C/T cg03006477 chr6:74432658 CD109 0.36 6.31 0.33 9.1e-10 Blood protein levels;Calcium levels; CRC cis rs2882667 0.858 rs13170388 chr5:138436865 A/G cg04439458 chr5:138467593 SIL1 -0.35 -5.98 -0.31 5.95e-9 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs9322193 0.566 rs12528243 chr6:150219627 G/A cg13206674 chr6:150067644 NUP43 0.45 5.69 0.3 2.85e-8 Lung cancer; CRC cis rs13108904 0.901 rs1680073 chr4:1280337 G/A cg05665937 chr4:1216051 CTBP1 -0.39 -5.99 -0.31 5.58e-9 Obesity-related traits; CRC cis rs4790333 0.967 rs2002863 chr17:2269769 C/T cg02569219 chr17:2266849 SGSM2 0.6 9.36 0.46 1.32e-18 Proinsulin levels; CRC cis rs4862750 0.872 rs13143414 chr4:187878213 G/A cg24874828 chr4:187887005 NA -0.34 -5.92 -0.31 8.26e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs12824058 0.549 rs4759453 chr12:130824565 C/G cg24838063 chr12:130822603 PIWIL1 0.56 9.39 0.46 1.03e-18 Menopause (age at onset); CRC cis rs17125944 0.505 rs2295826 chr14:53174923 C/T cg00686598 chr14:53173677 PSMC6 -1.04 -9.95 -0.48 1.45e-20 Alzheimer's disease (late onset); CRC cis rs1552244 0.938 rs67667957 chr3:10167264 G/C cg16606324 chr3:10149918 C3orf24 0.71 9.42 0.46 7.95e-19 Alzheimer's disease; CRC cis rs6456156 1.000 rs7761159 chr6:167519907 T/A cg07513332 chr6:167530253 CCR6 0.43 7.76 0.39 1.08e-13 Primary biliary cholangitis; CRC cis rs7618915 0.547 rs4130905 chr3:52709831 A/T cg05573699 chr3:52720067 GNL3;PBRM1 -0.45 -6.32 -0.33 8.47e-10 Bipolar disorder; CRC trans rs800082 0.516 rs1178896 chr3:144240689 A/T cg24215973 chr2:240111563 HDAC4 0.45 6.36 0.33 6.88e-10 Smoking behavior; CRC cis rs11098499 0.865 rs9994730 chr4:120381564 A/C cg09307838 chr4:120376055 NA 0.7 10.79 0.51 1.95e-23 Corneal astigmatism; CRC trans rs1656966 1.000 rs1656966 chr3:186466252 C/T cg07355693 chr12:125667907 NA 0.42 6.44 0.33 4.15e-10 Myopia (pathological); CRC cis rs6459804 0.844 rs76501205 chr7:157508941 A/T cg05585630 chr7:157510462 PTPRN2 -0.43 -6.86 -0.35 3.39e-11 Bipolar disorder and schizophrenia; CRC cis rs9926296 0.744 rs164746 chr16:89709019 C/T cg03605463 chr16:89740564 NA 0.5 7.24 0.37 3.16e-12 Vitiligo; CRC cis rs34779708 0.702 rs4007272 chr10:35546859 T/G cg03585969 chr10:35415529 CREM 0.52 6.79 0.35 5.37e-11 Inflammatory bowel disease;Crohn's disease; CRC cis rs909341 0.710 rs6089953 chr20:62291008 C/T cg16989086 chr20:62203971 PRIC285 0.52 6.75 0.35 6.8e-11 Atopic dermatitis; CRC cis rs1862618 0.853 rs863840 chr5:56128999 C/G cg03609598 chr5:56110824 MAP3K1 -0.76 -9.26 -0.45 2.65e-18 Initial pursuit acceleration; CRC cis rs2576037 0.796 rs2247221 chr18:44580082 C/T cg07416455 chr18:44543612 TCEB3CL;KATNAL2 0.41 6.04 0.32 4.12e-9 Personality dimensions; CRC cis rs6951245 0.938 rs78351779 chr7:1097023 G/C cg21664854 chr7:1097933 C7orf50;GPR146 0.78 8.81 0.44 7.57e-17 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs7809950 1.000 rs10274041 chr7:107261556 C/T cg23024343 chr7:107201750 COG5 0.58 8.32 0.42 2.39e-15 Coronary artery disease; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg04767442 chr6:49817519 CRISP1 0.39 5.97 0.31 6.17e-9 Response to antipsychotic treatment; CRC trans rs4650994 1.000 rs4650993 chr1:178515187 A/G cg05059571 chr16:84539110 KIAA1609 -0.48 -7.34 -0.38 1.63e-12 HDL cholesterol levels;HDL cholesterol; CRC cis rs2153535 0.580 rs9392220 chr6:8457946 G/A cg21535247 chr6:8435926 SLC35B3 0.51 7.9 0.4 4.36e-14 Motion sickness; CRC trans rs12495832 0.778 rs76846626 chr3:147907283 C/T cg10221266 chr7:153579447 NA 0.56 6.13 0.32 2.54e-9 Chin dimples; CRC cis rs116095464 0.614 rs4371799 chr5:268192 C/A cg22857025 chr5:266934 NA -1.19 -16.52 -0.67 4.72e-45 Breast cancer; CRC cis rs1997103 1.000 rs2877284 chr7:55408778 A/G cg17469321 chr7:55412551 NA 0.72 11.28 0.53 3.48e-25 QRS interval (sulfonylurea treatment interaction); CRC cis rs4665809 0.556 rs6730311 chr2:26419474 C/T cg04944784 chr2:26401820 FAM59B -0.84 -11.03 -0.52 2.86e-24 Gut microbiome composition (summer); CRC trans rs1814175 0.817 rs1851858 chr11:49855638 G/A cg21153622 chr11:89784906 NA -0.38 -6.14 -0.32 2.37e-9 Height; CRC cis rs55788414 0.932 rs12102728 chr16:81181436 C/T cg06400318 chr16:81190750 PKD1L2 -0.62 -7.02 -0.36 1.27e-11 Left ventricular obstructive tract defect (maternal effect); CRC cis rs7259376 0.902 rs12610462 chr19:22551462 C/T cg02657401 chr19:22469223 NA -0.32 -7.0 -0.36 1.44e-11 Menopause (age at onset); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg03145124 chr4:76649546 USO1 0.54 7.6 0.39 3.19e-13 Response to antipsychotic treatment; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg20760063 chr17:41277580 NBR2;BRCA1 0.42 6.3 0.33 9.67e-10 Liver disease severity in Alagille syndrome; CRC cis rs72781680 0.948 rs72796319 chr2:24133027 T/C cg08917208 chr2:24149416 ATAD2B 0.91 9.28 0.46 2.41e-18 Lymphocyte counts; CRC cis rs6582630 0.615 rs10880642 chr12:38554152 A/G cg26384229 chr12:38710491 ALG10B -0.43 -6.28 -0.33 1.06e-9 Drug-induced liver injury (flucloxacillin); CRC cis rs734999 0.505 rs10910108 chr1:2539532 A/G cg18854424 chr1:2615690 NA 0.5 10.11 0.49 4.27e-21 Ulcerative colitis; CRC cis rs754466 0.606 rs11002306 chr10:79591519 A/T cg26805224 chr10:79626177 DLG5 -0.48 -6.93 -0.36 2.18e-11 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs7191439 0.858 rs8050715 chr16:88780923 C/G cg02389323 chr16:88786976 FAM38A 0.87 8.08 0.41 1.23e-14 Plateletcrit; CRC cis rs4665809 1.000 rs1030730 chr2:26284143 T/C cg04944784 chr2:26401820 FAM59B -0.65 -8.02 -0.4 1.93e-14 Gut microbiome composition (summer); CRC trans rs2303319 0.504 rs961421 chr2:162626099 G/C cg27342122 chr8:133787442 PHF20L1 -0.72 -6.09 -0.32 3.2e-9 Cognitive function; CRC cis rs4711336 0.935 rs3818529 chr6:33661106 T/C cg14003231 chr6:33640908 ITPR3 0.43 7.04 0.36 1.16e-11 Height; CRC cis rs4253772 0.637 rs6008339 chr22:46650846 C/T cg24881330 chr22:46731750 TRMU 0.56 6.6 0.34 1.61e-10 LDL cholesterol;Cholesterol, total; CRC cis rs11711311 1.000 rs62268168 chr3:113489447 A/T cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.53 -7.24 -0.37 3.24e-12 IgG glycosylation; CRC trans rs4263408 0.934 rs9683743 chr4:39703194 A/C cg14577476 chr17:49337432 MBTD1;UTP18 -0.37 -6.07 -0.32 3.57e-9 Plasma amyloid beta peptide concentrations (ABx-40); CRC trans rs617791 0.508 rs747526 chr11:65776071 C/A cg17712092 chr4:129076599 LARP1B -0.47 -6.75 -0.35 6.52e-11 Breast cancer; CRC cis rs3741151 0.892 rs2027760 chr11:73036481 G/A cg17517138 chr11:73019481 ARHGEF17 0.63 6.62 0.34 1.43e-10 GIP levels in response to oral glucose tolerance test (120 minutes); CRC cis rs9398803 0.865 rs7738135 chr6:126829981 G/A cg19875578 chr6:126661172 C6orf173 0.42 5.86 0.31 1.15e-8 Male-pattern baldness; CRC trans rs1814175 0.645 rs1722000 chr11:49917928 A/C cg15704280 chr7:45808275 SEPT13 -0.95 -16.82 -0.68 3.11e-46 Height; CRC cis rs7666738 0.861 rs5014702 chr4:99052102 C/A cg05340658 chr4:99064831 C4orf37 0.62 9.61 0.47 1.96e-19 Colonoscopy-negative controls vs population controls; CRC cis rs12550646 0.600 rs10110994 chr8:41671503 A/G cg12180191 chr8:41686706 ANK1 -0.48 -7.08 -0.36 8.59e-12 Reticulocyte fraction of red cells;Reticulocyte count; CRC cis rs3924048 0.559 rs6541039 chr1:12626261 T/C cg23650765 chr1:12612165 NA 0.3 5.75 0.3 2.03e-8 Optic cup area; CRC cis rs2404602 0.647 rs12898810 chr15:76904738 T/C cg03037974 chr15:76606532 NA -0.5 -7.07 -0.36 9.6e-12 Blood metabolite levels; CRC cis rs7617773 0.817 rs9830016 chr3:48282494 A/G cg11946769 chr3:48343235 NME6 0.61 8.47 0.42 8.03e-16 Coronary artery disease; CRC cis rs736408 0.609 rs13082208 chr3:52781539 T/G cg18404041 chr3:52824283 ITIH1 -0.44 -9.1 -0.45 8.91e-18 Bipolar disorder; CRC cis rs1200821 0.535 rs1208783 chr10:37767467 A/G cg00409905 chr10:38381863 ZNF37A -0.48 -7.14 -0.37 5.95e-12 Hemostatic factors and hematological phenotypes; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg12128893 chr10:75255807 PPP3CB 0.5 6.69 0.35 9.6e-11 Thyroid stimulating hormone; CRC cis rs7493 1.000 rs2299265 chr7:95048870 C/G cg04155289 chr7:94953770 PON1 -0.62 -7.74 -0.39 1.23e-13 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs6547741 1.000 rs6718128 chr2:27833752 A/G cg27432699 chr2:27873401 GPN1 -0.73 -13.14 -0.59 5.49e-32 Oral cavity cancer; CRC cis rs10504229 0.609 rs56289889 chr8:58116276 G/C cg21724239 chr8:58056113 NA 0.49 6.81 0.35 4.75e-11 Developmental language disorder (linguistic errors); CRC cis rs6964587 1.000 rs2299238 chr7:91654517 G/A cg17063962 chr7:91808500 NA 0.8 14.2 0.62 5.1e-36 Breast cancer; CRC cis rs798554 0.548 rs1639064 chr7:2896544 G/A cg13628971 chr7:2884303 GNA12 0.41 6.12 0.32 2.61e-9 Height; CRC trans rs2303319 0.504 rs62189003 chr2:162548104 T/A cg18122310 chr12:50236657 BCDIN3D -0.74 -6.19 -0.32 1.81e-9 Cognitive function; CRC cis rs3806843 0.966 rs7710380 chr5:140156264 T/C cg16607685 chr5:140181889 PCDHA2;PCDHA1;PCDHA3 -0.26 -5.95 -0.31 6.8e-9 Depressive symptoms (multi-trait analysis); CRC cis rs968567 0.638 rs7943728 chr11:61547068 G/A cg00603274 chr11:61596626 FADS2 -0.82 -9.73 -0.47 7.78e-20 Blood metabolite levels;Rheumatoid arthritis;Vitiligo;Glycerophospholipid levels; CRC cis rs16937 0.662 rs11240376 chr1:205146460 A/G cg00857998 chr1:205179979 DSTYK 0.41 5.68 0.3 2.94e-8 Schizophrenia; CRC cis rs2230307 0.536 rs581097 chr1:100515920 C/T cg24955406 chr1:100503596 HIAT1 0.61 7.32 0.37 1.88e-12 Carotid intima media thickness; CRC cis rs765787 0.530 rs2413785 chr15:45530381 T/C cg24006582 chr15:45444508 DUOX1 -0.57 -8.74 -0.43 1.19e-16 Uric acid levels; CRC cis rs2857891 0.695 rs1907609 chr11:6991389 G/A cg04053776 chr11:6947353 ZNF215 0.43 6.68 0.35 1.03e-10 Response to cytadine analogues (cytosine arabinoside); CRC cis rs2692947 0.644 rs772154 chr2:97021664 G/T cg23100626 chr2:96804247 ASTL 0.28 7.08 0.36 8.68e-12 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; CRC cis rs9517320 0.967 rs6491430 chr13:99178276 G/A cg07423050 chr13:99094983 FARP1 0.43 6.54 0.34 2.41e-10 Longevity; CRC cis rs910316 0.737 rs175065 chr14:75494983 T/C cg11812906 chr14:75593930 NEK9 -0.57 -8.81 -0.44 7.2e-17 Height; CRC cis rs72781680 0.611 rs72783625 chr2:24315540 C/T cg20701182 chr2:24300061 SF3B14 0.61 7.18 0.37 4.57e-12 Lymphocyte counts; CRC cis rs8180040 0.764 rs13061071 chr3:47138708 G/A cg02527881 chr3:46936655 PTH1R -0.39 -7.29 -0.37 2.31e-12 Colorectal cancer; CRC cis rs55823223 0.618 rs11867339 chr17:73862093 A/G cg10935138 chr17:73851978 WBP2 0.64 7.49 0.38 6.19e-13 Psoriasis; CRC cis rs11958404 0.932 rs72816574 chr5:157429882 T/C cg05962755 chr5:157440814 NA 1.01 12.88 0.58 5.12e-31 IgG glycosylation; CRC cis rs1843834 0.574 rs6436499 chr2:225456551 A/T cg22455342 chr2:225449267 CUL3 0.63 8.26 0.41 3.61e-15 IgE levels in asthmatics (D.p. specific); CRC cis rs2404602 0.655 rs4886824 chr15:76969256 A/G cg03037974 chr15:76606532 NA 0.69 12.34 0.56 5.33e-29 Blood metabolite levels; CRC cis rs1552244 1.000 rs6764168 chr3:10123805 A/G cg16606324 chr3:10149918 C3orf24 0.73 9.87 0.48 2.75e-20 Alzheimer's disease; CRC cis rs1008375 0.931 rs6813374 chr4:17649494 T/C cg02297831 chr4:17616191 MED28 0.5 6.71 0.35 8.74e-11 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs57590327 0.508 rs7621968 chr3:81951460 A/G cg07356753 chr3:81810745 GBE1 -0.55 -7.49 -0.38 6.2800000000000005e-13 Extraversion; CRC cis rs9549328 0.731 rs7983602 chr13:113620482 A/G cg17524180 chr13:113633600 MCF2L -0.64 -12.22 -0.56 1.49e-28 Systolic blood pressure; CRC cis rs12908161 1.000 rs56864281 chr15:85357649 C/A cg11189052 chr15:85197271 WDR73 0.56 7.53 0.38 5.02e-13 Schizophrenia; CRC cis rs1552244 0.882 rs61429272 chr3:10037320 G/C cg00166722 chr3:10149974 C3orf24 0.61 8.0 0.4 2.17e-14 Alzheimer's disease; CRC cis rs514406 0.861 rs1749907 chr1:53259658 C/T cg27535305 chr1:53392650 SCP2 0.39 6.97 0.36 1.72e-11 Monocyte count; CRC cis rs6762 0.719 rs1130698 chr11:838542 C/T cg03885332 chr11:832357 CD151 -0.42 -6.18 -0.32 1.88e-9 Mean platelet volume; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg08951903 chr10:44070173 ZNF239 0.4 5.97 0.31 6.31e-9 Liver disease severity in Alagille syndrome; CRC cis rs2032447 0.802 rs198853 chr6:26104096 T/C cg26028573 chr6:26043587 HIST1H2BB -0.44 -6.37 -0.33 6.25e-10 Intelligence (multi-trait analysis); CRC cis rs9911578 1.000 rs4793952 chr17:56608465 C/T cg05425664 chr17:57184151 TRIM37 0.52 8.16 0.41 7.11e-15 Intelligence (multi-trait analysis); CRC cis rs7119 0.635 rs59745219 chr15:77884130 A/G cg27398640 chr15:77910606 LINGO1 0.38 6.9 0.36 2.66e-11 Type 2 diabetes; CRC trans rs10983614 1.000 rs7867776 chr9:120072627 A/G cg12958836 chr12:8185024 FOXJ2 0.49 6.77 0.35 5.88e-11 Survival in pancreatic cancer; CRC cis rs561341 0.941 rs17780080 chr17:30343146 G/A cg12193833 chr17:30244370 NA -0.75 -8.76 -0.44 1.01e-16 Hip circumference adjusted for BMI; CRC cis rs13315871 0.929 rs9854438 chr3:58277327 G/A cg20936604 chr3:58311152 NA -0.61 -5.83 -0.31 1.35e-8 Cholesterol, total; CRC cis rs7772486 0.692 rs1577916 chr6:146069789 G/A cg23711669 chr6:146136114 FBXO30 -0.75 -12.66 -0.57 3.45e-30 Lobe attachment (rater-scored or self-reported); CRC cis rs4423214 0.879 rs1792282 chr11:71135166 G/A cg05163923 chr11:71159392 DHCR7 -0.63 -7.74 -0.39 1.2e-13 Vitamin D levels; CRC cis rs10256972 0.641 rs12702017 chr7:1129413 C/T cg16145915 chr7:1198662 ZFAND2A -0.4 -7.9 -0.4 4.33e-14 Longevity;Endometriosis; CRC cis rs6500602 0.727 rs3761681 chr16:4566857 C/T cg08645402 chr16:4508243 NA 0.63 11.28 0.53 3.55e-25 Schizophrenia; CRC cis rs2249625 0.526 rs17781511 chr6:72845455 C/T cg18830697 chr6:72922368 RIMS1 0.4 7.69 0.39 1.7e-13 Acute urticaria and angioedema (non-steroidal anti-inflammatory drug-induced); CRC cis rs7572644 0.699 rs7577342 chr2:28205581 A/G cg27432699 chr2:27873401 GPN1 0.41 5.67 0.3 3.12e-8 Response to carboplatin and paclitaxel in ovarian cancer (Caspase 3/7 EC50); CRC cis rs1801251 1.000 rs12478564 chr2:233598340 C/T cg25237894 chr2:233734115 C2orf82 0.54 8.77 0.44 9.91e-17 Coronary artery disease; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg19793034 chr4:1284190 MAEA 0.49 6.34 0.33 7.42e-10 Thyroid stimulating hormone; CRC cis rs7113874 0.610 rs10840055 chr11:8494345 C/T cg20771178 chr11:8615675 STK33 0.34 5.67 0.3 3.07e-8 Body mass index in physically active individuals;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs2949837 0.581 rs2960437 chr7:45977352 G/A cg15898840 chr7:45960834 IGFBP3 0.45 7.4 0.38 1.14e-12 Sitting height ratio; CRC cis rs9611565 0.580 rs5758449 chr22:42140160 C/T cg03806693 chr22:41940476 POLR3H 0.66 9.24 0.45 3.06e-18 Vitiligo; CRC cis rs7607369 0.526 rs4674322 chr2:219513782 C/T cg02176678 chr2:219576539 TTLL4 0.55 7.04 0.36 1.1e-11 Red blood cell count;Amyotrophic lateral sclerosis; CRC cis rs2742417 0.603 rs1019129 chr3:45780780 T/C cg04837898 chr3:45731254 SACM1L -0.45 -7.28 -0.37 2.49e-12 Response to anti-depressant treatment in major depressive disorder; CRC cis rs473651 0.716 rs548179 chr2:239320505 G/A cg08773314 chr2:239334832 ASB1 0.36 8.17 0.41 6.49e-15 Multiple system atrophy; CRC cis rs6951245 0.554 rs76243429 chr7:1152543 C/T cg03188948 chr7:1209495 NA 0.56 6.65 0.34 1.25e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs7086627 0.515 rs10887894 chr10:82209952 A/G cg09626299 chr10:82213104 TSPAN14 -0.37 -6.23 -0.33 1.39e-9 Post bronchodilator FEV1; CRC cis rs11098699 0.821 rs6811839 chr4:124222326 G/A cg09941581 chr4:124220074 SPATA5 0.43 6.39 0.33 5.51e-10 Mosquito bite size; CRC cis rs9549260 0.651 rs9549251 chr13:41228650 A/G cg21288729 chr13:41239152 FOXO1 0.48 7.56 0.38 3.94e-13 Red blood cell count; CRC cis rs4819052 0.851 rs13052344 chr21:46676101 C/T cg02159808 chr21:46707872 POFUT2;LOC642852 0.53 6.94 0.36 2.15e-11 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs7772486 0.764 rs7762562 chr6:146158994 T/C cg13319975 chr6:146136371 FBXO30 -0.44 -6.53 -0.34 2.49e-10 Lobe attachment (rater-scored or self-reported); CRC cis rs881375 0.967 rs1008381 chr9:123681116 T/C cg09419670 chr9:123605666 PSMD5;LOC253039 0.59 8.6 0.43 3.34e-16 Rheumatoid arthritis; CRC cis rs79387448 0.745 rs72995658 chr2:103176773 A/G cg09003973 chr2:102972529 NA 0.72 7.95 0.4 2.96e-14 Gut microbiota (bacterial taxa); CRC cis rs9457247 1.000 rs2757047 chr6:167374489 C/T cg23791538 chr6:167370224 RNASET2 0.39 6.07 0.32 3.46e-9 Crohn's disease; CRC cis rs1218582 0.741 rs4339857 chr1:154888962 A/G cg09359103 chr1:154839909 KCNN3 -0.71 -12.61 -0.57 5.17e-30 Prostate cancer; CRC cis rs13118159 0.801 rs7664474 chr4:1329116 T/A cg21620606 chr4:1342894 KIAA1530 0.53 9.54 0.47 3.33e-19 Longevity; CRC cis rs11723261 0.582 rs11735742 chr4:142550 C/T cg12746427 chr4:53362 ZNF718;ZNF595 -0.46 -6.45 -0.34 4.01e-10 Immune response to smallpox vaccine (IL-6); CRC cis rs7552404 1.000 rs11161515 chr1:76212559 C/T cg22875332 chr1:76189707 ACADM 0.7 9.46 0.46 5.93e-19 Blood metabolite levels;Acylcarnitine levels; CRC cis rs34779708 0.931 rs67976880 chr10:35372261 G/C cg03585969 chr10:35415529 CREM 0.67 8.87 0.44 4.78e-17 Inflammatory bowel disease;Crohn's disease; CRC cis rs9341808 0.754 rs1015158 chr6:80945745 C/T cg08355045 chr6:80787529 NA 0.42 6.81 0.35 4.67e-11 Sitting height ratio; CRC cis rs10791323 0.628 rs1893850 chr11:133705356 T/C cg00579200 chr11:133705235 NA -0.41 -5.96 -0.31 6.32e-9 Childhood ear infection; CRC cis rs1552244 0.554 rs58020561 chr3:10054682 A/G cg08888203 chr3:10149979 C3orf24 0.48 7.18 0.37 4.64e-12 Alzheimer's disease; CRC cis rs172166 0.637 rs1225595 chr6:28151340 A/T cg21251018 chr6:28226885 NKAPL 0.47 7.36 0.38 1.44e-12 Cardiac Troponin-T levels; CRC cis rs13031619 0.660 rs35668314 chr2:3702673 C/T cg19825600 chr2:3704501 ALLC -0.53 -6.37 -0.33 6.52e-10 Response to inhaled corticosteroid treatment in asthma (change in FEV1); CRC cis rs7894051 1.000 rs2185746 chr10:135195332 A/G cg20534287 chr10:135191450 PAOX -0.68 -6.53 -0.34 2.43e-10 Lifespan; CRC cis rs1865760 0.532 rs2794719 chr6:26088890 T/G cg16482183 chr6:26056742 HIST1H1C 0.51 7.31 0.37 2.02e-12 Height; CRC trans rs2727020 0.658 rs7120136 chr11:49384358 A/C cg11707556 chr5:10655725 ANKRD33B -0.38 -7.21 -0.37 3.97e-12 Coronary artery disease; CRC cis rs73200209 0.704 rs56258518 chr12:116596371 G/A cg01776926 chr12:116560359 MED13L -0.62 -7.21 -0.37 3.98e-12 Total body bone mineral density; CRC cis rs13191362 1.000 rs35723993 chr6:163008197 C/T cg21926612 chr6:163149169 PACRG;PARK2 0.78 10.8 0.51 1.77e-23 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs7615952 0.599 rs7631268 chr3:125755664 T/A cg18479299 chr3:125709523 NA -0.54 -6.28 -0.33 1.04e-9 Blood pressure (smoking interaction); CRC trans rs7819412 0.521 rs10110684 chr8:11039159 G/C cg06636001 chr8:8085503 FLJ10661 -0.45 -6.5 -0.34 2.94e-10 Triglycerides; CRC cis rs1387259 0.698 rs4579969 chr12:48779562 C/T cg21466736 chr12:48725269 NA 0.38 5.85 0.31 1.22e-8 Obstructive sleep apnea trait (apnea hypopnea index); CRC cis rs870825 0.929 rs55746424 chr4:185589603 C/T cg07424746 chr4:185654737 MLF1IP -0.63 -5.97 -0.31 6.28e-9 Blood protein levels; CRC cis rs4843747 0.619 rs66508972 chr16:88086385 C/G cg17633681 chr16:88106987 BANP 0.81 13.65 0.6 6.22e-34 Menopause (age at onset); CRC cis rs7615952 0.512 rs2979334 chr3:125358824 G/A cg11143507 chr3:125485238 NA -0.58 -7.46 -0.38 7.69e-13 Blood pressure (smoking interaction); CRC cis rs9549328 0.800 rs1317507 chr13:113631780 G/T cg16822035 chr13:113633379 MCF2L -0.29 -6.07 -0.32 3.61e-9 Systolic blood pressure; CRC cis rs2969070 0.831 rs7799266 chr7:2506595 G/A cg03277898 chr7:2518824 NA -0.43 -6.16 -0.32 2.13e-9 Diastolic blood pressure; CRC cis rs2976388 0.609 rs2585144 chr8:143800269 A/T cg22687807 chr8:143858763 LYNX1 0.51 8.97 0.44 2.24e-17 Urinary tract infection frequency; CRC trans rs7615952 0.512 rs11921452 chr3:125359750 A/G cg02560186 chr11:3602584 NA -0.63 -9.54 -0.47 3.23e-19 Blood pressure (smoking interaction); CRC cis rs748404 0.697 rs574065 chr15:43550655 A/G cg02155558 chr15:43621948 ADAL;LCMT2 -0.4 -5.93 -0.31 7.5e-9 Lung cancer; CRC trans rs2243480 1.000 rs4718269 chr7:65200778 C/G cg10756647 chr7:56101905 PSPH -0.7 -7.52 -0.38 5.25e-13 Diabetic kidney disease; CRC cis rs9911578 1.000 rs10401050 chr17:56953786 A/C cg05425664 chr17:57184151 TRIM37 -0.49 -7.77 -0.39 9.89e-14 Intelligence (multi-trait analysis); CRC cis rs10883723 0.810 rs12265877 chr10:104247247 C/G cg22532475 chr10:104410764 TRIM8 -0.36 -6.66 -0.34 1.18e-10 Allergic disease (asthma, hay fever or eczema); CRC cis rs1401999 0.606 rs7644687 chr3:183753353 A/G cg01324343 chr3:183735012 ABCC5 0.74 11.65 0.54 1.64e-26 Anterior chamber depth; CRC cis rs7811142 0.830 rs6945952 chr7:99981775 A/G cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.15 16.66 0.68 1.34e-45 Platelet count; CRC cis rs1707322 0.893 rs9919275 chr1:46441360 A/C cg03146154 chr1:46216737 IPP 0.51 7.06 0.36 1.01e-11 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg05317630 chr4:184366047 CDKN2AIP 0.45 6.08 0.32 3.34e-9 Anxiety disorder; CRC cis rs3849570 0.643 rs11705789 chr3:81969196 G/T cg07356753 chr3:81810745 GBE1 -0.59 -8.25 -0.41 3.8e-15 Waist circumference;Body mass index; CRC trans rs7873102 0.702 rs7028020 chr9:38007747 C/T cg24311251 chr13:44453387 CCDC122;C13orf31 -0.42 -6.68 -0.35 1.02e-10 Brain structure; CRC cis rs3771570 0.901 rs4675944 chr2:242430170 C/T cg21155796 chr2:242212141 HDLBP 0.59 6.69 0.35 9.74e-11 Prostate cancer; CRC cis rs600806 0.821 rs10127790 chr1:109891133 C/T cg23032129 chr1:109941072 SORT1 -0.27 -5.79 -0.3 1.65e-8 Intelligence (multi-trait analysis); CRC trans rs931812 0.757 rs35569317 chr8:101907971 T/C cg20993868 chr7:22813445 NA 0.45 8.99 0.44 1.99e-17 Attention deficit hyperactivity disorder and conduct disorder; CRC cis rs61160187 0.582 rs1021005 chr5:60191460 A/G cg16298547 chr5:60138761 ELOVL7 -0.28 -5.93 -0.31 7.59e-9 Educational attainment (years of education);Educational attainment (college completion); CRC cis rs457287 0.892 rs461130 chr9:4834597 C/T cg14182974 chr9:4791918 RCL1 0.37 6.02 0.32 4.54e-9 Platelet count; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg09378497 chr16:1525169 CLCN7 0.45 6.4 0.33 5.32e-10 Anxiety disorder; CRC cis rs12928939 0.862 rs7197104 chr16:71794061 C/T cg03805757 chr16:71968109 PKD1L3 -0.47 -5.95 -0.31 6.74e-9 Post bronchodilator FEV1; CRC cis rs4380275 1.000 rs73143802 chr2:773826 T/C cg27237671 chr2:676223 TMEM18 -0.43 -6.11 -0.32 2.76e-9 Adverse response to chemotherapy (neutropenia/leucopenia) (doxorubicin); CRC cis rs7811142 1.000 rs4472444 chr7:100070758 T/C cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.91 12.27 0.56 9.02e-29 Platelet count; CRC cis rs17826219 0.636 rs2449770 chr17:29101064 G/T cg13385521 chr17:29058706 SUZ12P 0.73 8.33 0.42 2.14e-15 Body mass index; CRC cis rs9916302 0.904 rs55689507 chr17:37404436 G/C cg15445000 chr17:37608096 MED1 0.41 8.93 0.44 2.96e-17 Glomerular filtration rate (creatinine); CRC cis rs7312933 1.000 rs12372597 chr12:42412850 C/T cg17420585 chr12:42539391 GXYLT1 -0.44 -6.37 -0.33 6.27e-10 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CRC cis rs9488822 0.702 rs12196154 chr6:116327471 T/G cg18764771 chr6:116381957 FRK 0.25 7.0 0.36 1.42e-11 Cholesterol, total;LDL cholesterol; CRC cis rs6674176 0.628 rs2240447 chr1:44415415 C/T cg13606994 chr1:44402422 ARTN -0.37 -6.12 -0.32 2.63e-9 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Cognitive ability; CRC cis rs796364 0.806 rs11688168 chr2:200916004 G/A cg25936922 chr2:200820526 C2orf60;C2orf47 -0.7 -6.57 -0.34 2.02e-10 Schizophrenia; CRC cis rs6952808 0.608 rs58120505 chr7:2029867 T/C cg02951883 chr7:2050386 MAD1L1 -0.66 -10.91 -0.52 7.62e-24 Bipolar disorder and schizophrenia; CRC cis rs11148252 0.532 rs9526975 chr13:53255804 C/T cg00495681 chr13:53174319 NA 1.03 20.74 0.75 1.06e-61 Lewy body disease; CRC cis rs12044355 0.929 rs1954175 chr1:231855410 T/C cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX 0.45 6.03 0.32 4.5e-9 Alzheimer's disease; CRC cis rs4713118 0.699 rs200978 chr6:27853168 C/G cg21251018 chr6:28226885 NKAPL 0.48 6.64 0.34 1.29e-10 Parkinson's disease; CRC cis rs116095464 0.558 rs62347678 chr5:227496 A/G cg22857025 chr5:266934 NA -1.16 -16.31 -0.67 2.94e-44 Breast cancer; CRC trans rs459571 0.959 rs456205 chr9:136911146 G/A cg09836344 chr4:1243392 C4orf42;CTBP1 -0.82 -11.49 -0.54 6.46e-26 Platelet distribution width; CRC cis rs2836633 1.000 rs2836634 chr21:40068230 T/A cg12884169 chr21:40033163 ERG 0.34 7.54 0.38 4.71e-13 Coronary artery disease; CRC trans rs2078087 1.000 rs11577151 chr1:183381795 A/G cg01099024 chr14:70347833 SMOC1 -0.48 -6.1 -0.32 2.98e-9 Obesity-related traits; CRC cis rs6089584 0.888 rs6089624 chr20:60619907 C/G cg06108461 chr20:60628389 TAF4 -0.92 -15.9 -0.66 1.28e-42 Body mass index; CRC trans rs7615952 0.866 rs6438949 chr3:125650064 G/C cg16558177 chr4:4109446 NA -0.47 -6.09 -0.32 3.21e-9 Blood pressure (smoking interaction); CRC cis rs3820068 0.581 rs34453754 chr1:15993208 G/C cg13390004 chr1:15929781 NA 0.52 7.25 0.37 2.93e-12 Systolic blood pressure; CRC cis rs4555082 0.872 rs7153832 chr14:105730563 G/T cg10792982 chr14:105748885 BRF1 0.36 6.17 0.32 2.04e-9 Mean platelet volume;Platelet distribution width; CRC cis rs9916302 0.706 rs4287601 chr17:37513852 T/C cg15445000 chr17:37608096 MED1 -0.35 -6.12 -0.32 2.59e-9 Glomerular filtration rate (creatinine); CRC cis rs6570726 0.902 rs396681 chr6:145853603 T/C cg23711669 chr6:146136114 FBXO30 0.72 12.82 0.58 8.71e-31 Lobe attachment (rater-scored or self-reported); CRC cis rs11122272 0.735 rs2749723 chr1:231493302 A/G cg06096015 chr1:231504339 EGLN1 0.38 5.71 0.3 2.56e-8 Hemoglobin concentration; CRC cis rs2836974 0.897 rs2026267 chr21:40711477 C/A cg11644478 chr21:40555479 PSMG1 0.73 10.47 0.5 2.51e-22 Cognitive function; CRC cis rs6500602 0.648 rs7702 chr16:4560929 G/C cg14951292 chr16:4525986 HMOX2;NMRAL1 0.74 10.51 0.5 1.78e-22 Schizophrenia; CRC cis rs55894132 1 rs55894132 chr14:23408837 C/G cg25600027 chr14:23388339 RBM23 -0.43 -6.38 -0.33 5.84e-10 Intelligence (multi-trait analysis); CRC cis rs9858542 1.000 rs4283605 chr3:49678651 A/G cg07274523 chr3:49395745 GPX1 0.47 6.02 0.31 4.71e-9 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC trans rs7618501 0.633 rs2252833 chr3:50004209 C/T cg21665057 chr3:196295764 WDR53;FBXO45 0.57 8.96 0.44 2.49e-17 Intelligence (multi-trait analysis); CRC cis rs892961 0.836 rs35077273 chr17:75412415 T/C cg05865280 chr17:75406074 SEPT9 0.63 14.51 0.62 3.27e-37 Airflow obstruction; CRC trans rs2303319 0.504 rs12469302 chr2:162433831 G/T cg10498984 chr16:28874827 SH2B1 -0.73 -5.99 -0.31 5.54e-9 Cognitive function; CRC cis rs9733 0.596 rs34600506 chr1:150687808 C/G cg18016565 chr1:150552671 MCL1 0.45 6.52 0.34 2.57e-10 Tonsillectomy; CRC cis rs1348850 0.608 rs10176632 chr2:178225934 G/T cg22681709 chr2:178499509 PDE11A -0.31 -5.64 -0.3 3.64e-8 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs7666738 0.822 rs9992360 chr4:98937123 T/C cg05340658 chr4:99064831 C4orf37 0.6 9.35 0.46 1.41e-18 Colonoscopy-negative controls vs population controls; CRC cis rs6921919 0.583 rs9461459 chr6:28361916 T/C cg21251018 chr6:28226885 NKAPL 0.4 6.06 0.32 3.66e-9 Autism spectrum disorder or schizophrenia; CRC cis rs4665809 0.878 rs6748745 chr2:26364190 C/T cg27170947 chr2:26402098 FAM59B -0.47 -5.79 -0.3 1.62e-8 Gut microbiome composition (summer); CRC trans rs204595 0.896 rs28579261 chr7:20896148 C/G cg02372745 chr13:50365574 KPNA3 -0.45 -5.97 -0.31 6.04e-9 Depressive symptoms (stressful life events interaction); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg02113521 chr15:22892956 CYFIP1 0.43 7.16 0.37 5.43e-12 Liver disease severity in Alagille syndrome; CRC cis rs1878931 0.535 rs10852706 chr16:3412582 G/C cg26668626 chr16:3451006 ZNF174;ZNF434 0.49 6.09 0.32 3.14e-9 Body mass index (adult); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg12600378 chr5:52405361 MOCS2 0.41 6.39 0.33 5.52e-10 Liver disease severity in Alagille syndrome; CRC trans rs7647973 0.626 rs9824435 chr3:49674343 A/G cg21659725 chr3:3221576 CRBN 0.66 6.72 0.35 8.1e-11 Menarche (age at onset); CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg26726589 chr20:306364 SOX12 0.38 6.31 0.33 8.86e-10 Obesity-related traits; CRC cis rs4925386 0.840 rs6143036 chr20:60921721 C/A cg06026331 chr20:60912101 LAMA5 0.39 5.63 0.3 3.8e-8 Colorectal cancer;Colorectal cancer (SNP x SNP interaction); CRC cis rs7833986 0.501 rs2719226 chr8:57044066 A/G cg23139584 chr8:56987506 RPS20;SNORD54 0.93 12.59 0.57 6e-30 Height; CRC cis rs561341 0.883 rs4795661 chr17:30201774 T/A cg12193833 chr17:30244370 NA 0.55 6.82 0.35 4.32e-11 Hip circumference adjusted for BMI; CRC cis rs477692 0.692 rs7905095 chr10:131448143 C/T cg05714579 chr10:131428358 MGMT -0.71 -10.88 -0.51 9.71e-24 Response to temozolomide; CRC cis rs898097 0.737 rs3785521 chr17:80895769 A/G cg15369054 chr17:80825471 TBCD -0.52 -8.23 -0.41 4.34e-15 Breast cancer; CRC cis rs117623576 0.941 rs111864818 chr10:32426613 G/A cg03047570 chr10:32398778 NA -0.7 -6.99 -0.36 1.57e-11 Anti-saccade response; CRC cis rs929354 0.742 rs886677 chr7:157003782 T/A cg16102536 chr7:156981717 UBE3C 0.4 6.77 0.35 5.75e-11 Body mass index; CRC cis rs704795 0.902 rs11887784 chr2:27679919 A/G cg21248554 chr2:27665150 KRTCAP3 -0.33 -7.38 -0.38 1.27e-12 Menopause (age at onset); CRC cis rs67311347 0.549 rs60249586 chr3:40246659 G/A cg09455208 chr3:40491958 NA 0.32 6.65 0.34 1.24e-10 Renal cell carcinoma; CRC cis rs11098499 0.909 rs28555550 chr4:120211040 C/G cg24375607 chr4:120327624 NA 0.47 7.22 0.37 3.65e-12 Corneal astigmatism; CRC cis rs35306767 0.903 rs4522091 chr10:874116 G/T cg26597838 chr10:835615 NA 0.93 11.02 0.52 3.11e-24 Eosinophil percentage of granulocytes; CRC cis rs1552244 0.515 rs67342818 chr3:10166406 G/A cg08888203 chr3:10149979 C3orf24 0.71 8.57 0.43 4.18e-16 Alzheimer's disease; CRC cis rs8044995 0.501 rs55793998 chr16:68378985 G/T cg09835421 chr16:68378352 PRMT7 -0.76 -8.1 -0.41 1.12e-14 Schizophrenia; CRC cis rs4363385 0.669 rs2937264 chr1:153011026 C/T cg25856811 chr1:152973957 SPRR3 -0.25 -6.99 -0.36 1.51e-11 Inflammatory skin disease; CRC cis rs12024301 0.557 rs16861451 chr1:183646306 G/C cg11505048 chr1:183622726 RGL1;APOBEC4 0.73 6.43 0.33 4.43e-10 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs10992471 0.627 rs4744138 chr9:95291909 A/G cg14631576 chr9:95140430 CENPP -0.4 -6.81 -0.35 4.6e-11 Visceral adipose tissue/subcutaneous adipose tissue ratio; CRC cis rs863345 0.604 rs12078065 chr1:158465063 T/C cg12129480 chr1:158549410 OR10X1 -0.3 -6.35 -0.33 7.19e-10 Pneumococcal bacteremia; CRC cis rs11785693 0.862 rs6995565 chr8:4990461 C/T cg26367366 chr8:4980734 NA -0.66 -7.85 -0.4 5.91e-14 Neuroticism (multi-trait analysis);Neuroticism; CRC cis rs8067545 0.611 rs2703776 chr17:20137709 C/A cg13482628 chr17:19912719 NA -0.46 -7.33 -0.37 1.79e-12 Schizophrenia; CRC cis rs9467773 1.000 rs10946835 chr6:26533757 C/T cg09904177 chr6:26538194 HMGN4 0.86 14.9 0.63 9.92e-39 Intelligence (multi-trait analysis); CRC cis rs7493 0.950 rs7785705 chr7:95033803 A/T cg17330251 chr7:94953956 PON1 -0.59 -7.65 -0.39 2.27e-13 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs13191362 0.507 rs2803083 chr6:163111199 A/C cg21926612 chr6:163149169 PACRG;PARK2 0.6 9.38 0.46 1.12e-18 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs2929278 0.617 rs524908 chr15:44187991 G/T cg02155558 chr15:43621948 ADAL;LCMT2 -0.45 -6.14 -0.32 2.39e-9 Schizophrenia; CRC cis rs2839186 0.647 rs9976233 chr21:47616913 G/A cg26721908 chr21:47610096 LSS 0.45 7.39 0.38 1.21e-12 Testicular germ cell tumor; CRC cis rs35306767 0.953 rs34405399 chr10:981015 G/A cg20503657 chr10:835505 NA 0.77 9.75 0.47 6.59e-20 Eosinophil percentage of granulocytes; CRC trans rs11039798 0.699 rs7120775 chr11:48266736 C/G cg03929089 chr4:120376271 NA 0.66 6.31 0.33 9.22e-10 Axial length; CRC cis rs2530545 0.851 rs10276755 chr7:34679959 C/T cg14401837 chr7:34697493 NPSR1 0.41 5.68 0.3 2.96e-8 IgG glycosylation; CRC cis rs11958404 0.932 rs72816580 chr5:157432221 A/T cg05962755 chr5:157440814 NA 1.01 12.88 0.58 5.12e-31 IgG glycosylation; CRC cis rs887829 0.641 rs7586110 chr2:234590527 T/G cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.42 -6.32 -0.33 8.45e-10 Metabolic traits;Bilirubin levels;Cholelithiasis-related traits in sickle cell anemia;Metabolite levels;Total bilirubin levels in HIV-1 infection;Serum metabolite levels;Blood metabolite levels; CRC cis rs992157 0.798 rs12053514 chr2:219167965 C/T cg04731861 chr2:219085781 ARPC2 0.31 6.36 0.33 6.94e-10 Colorectal cancer; CRC cis rs11583043 0.874 rs72734253 chr1:101380718 A/C cg16556008 chr1:101360663 SLC30A7;EXTL2 0.56 7.58 0.39 3.49e-13 Ulcerative colitis;Inflammatory bowel disease; CRC cis rs1862618 0.671 rs2591961 chr5:56238597 A/G cg12311346 chr5:56204834 C5orf35 0.63 9.82 0.48 3.9e-20 Initial pursuit acceleration; CRC trans rs11764590 0.694 rs56072378 chr7:2104364 A/G cg11693508 chr17:37793320 STARD3 0.51 6.74 0.35 6.9e-11 Neuroticism; CRC cis rs13191362 1.000 rs36113695 chr6:163004733 T/A cg06582575 chr6:163149167 PACRG;PARK2 0.77 10.59 0.5 9.54e-23 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs3768617 0.510 rs2093984 chr1:183094314 T/C ch.1.3577855R chr1:183094577 LAMC1 0.85 14.6 0.63 1.48e-37 Fuchs's corneal dystrophy; CRC cis rs4731207 0.596 rs7790975 chr7:124577944 A/T cg23710748 chr7:124431027 NA -0.39 -6.12 -0.32 2.67e-9 Cutaneous malignant melanoma; CRC cis rs600806 0.815 rs10858088 chr1:109923586 C/T cg23032129 chr1:109941072 SORT1 -0.28 -6.06 -0.32 3.68e-9 Intelligence (multi-trait analysis); CRC cis rs12325245 0.536 rs12709002 chr16:58614337 A/C cg19824325 chr16:58548873 SETD6 0.87 5.81 0.31 1.44e-8 Schizophrenia; CRC cis rs13108904 0.935 rs4974575 chr4:1252028 A/G cg00684032 chr4:1343700 KIAA1530 0.39 5.81 0.31 1.47e-8 Obesity-related traits; CRC cis rs5753618 0.509 rs5749229 chr22:31587218 T/C cg22777020 chr22:31556080 RNF185 -0.53 -6.2 -0.32 1.72e-9 Colorectal cancer; CRC cis rs10864907 0.614 rs12711745 chr2:113700355 T/C cg06156847 chr2:113672199 IL1F7 -0.45 -6.78 -0.35 5.59e-11 Pulmonary function; CRC cis rs2380220 0.541 rs9285413 chr6:96023439 G/A cg23517279 chr6:96025343 MANEA 0.55 6.38 0.33 6.07e-10 Behavioural disinhibition (generation interaction); CRC cis rs1003719 0.715 rs6579 chr21:38568308 C/T cg10648535 chr21:38446584 PIGP;TTC3 -0.45 -6.34 -0.33 7.37e-10 Eye color traits; CRC cis rs7937682 0.855 rs527078 chr11:111479713 T/C cg19812747 chr11:111475976 SIK2 -0.57 -9.79 -0.47 5.04e-20 Primary sclerosing cholangitis; CRC cis rs3106136 0.967 rs11097409 chr4:95168515 C/A cg11021082 chr4:95130006 SMARCAD1 -0.46 -7.13 -0.37 6.34e-12 Capecitabine sensitivity; CRC cis rs1448094 0.511 rs6539921 chr12:86164163 G/A cg02569458 chr12:86230093 RASSF9 0.47 7.72 0.39 1.42e-13 Major depressive disorder; CRC cis rs6988985 0.560 rs2078674 chr8:143928233 G/T cg10324643 chr8:143916377 GML 0.37 6.23 0.32 1.45e-9 Plasma androstenedione levels in resected early stage-receptor positive breast cancer; CRC cis rs1707322 1.000 rs11211204 chr1:46317864 A/G cg06784218 chr1:46089804 CCDC17 0.51 9.03 0.45 1.45e-17 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs6933660 0.800 rs9383893 chr6:151757327 T/C cg14262678 chr6:151773367 RMND1;C6orf211 0.53 8.73 0.43 1.3e-16 Menarche (age at onset); CRC cis rs12477438 0.798 rs6705821 chr2:99602832 T/C cg26064155 chr2:99771622 LIPT1;TSGA10 -0.79 -11.26 -0.53 4.44e-25 Chronic sinus infection; CRC cis rs4423214 0.592 rs10898191 chr11:71194601 G/A cg05163923 chr11:71159392 DHCR7 -0.53 -5.61 -0.3 4.28e-8 Vitamin D levels; CRC trans rs61931739 0.534 rs11052986 chr12:34052578 T/C cg26384229 chr12:38710491 ALG10B 0.48 6.58 0.34 1.83e-10 Morning vs. evening chronotype; CRC cis rs1218582 0.772 rs6683557 chr1:154852307 C/G cg06221963 chr1:154839813 KCNN3 -0.78 -15.94 -0.66 8.46e-43 Prostate cancer; CRC cis rs116095464 0.558 rs7731089 chr5:290422 A/C cg22857025 chr5:266934 NA -1.24 -16.52 -0.67 4.4e-45 Breast cancer; CRC cis rs904251 0.523 rs2776872 chr6:37482787 C/G cg01843034 chr6:37503916 NA -0.43 -8.08 -0.41 1.21e-14 Cognitive performance; CRC cis rs7208859 0.573 rs216442 chr17:28931197 T/G cg19761014 chr17:28927070 LRRC37B2 0.56 5.68 0.3 2.94e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs853679 0.517 rs2275508 chr6:28094731 T/C cg03623178 chr6:28175578 NA 0.94 12.33 0.56 5.52e-29 Depression; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg05504270 chr16:72130759 DHX38 -0.38 -6.3 -0.33 9.33e-10 Liver disease severity in Alagille syndrome; CRC cis rs4604732 0.527 rs7539082 chr1:247627260 T/C cg12758973 chr1:247694275 LOC148824;OR2C3 0.42 6.1 0.32 2.98e-9 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CRC cis rs1950626 0.750 rs34061904 chr14:101435974 A/G cg02351406 chr14:101447389 SNORD114-20;SNORD114-21 0.96 15.57 0.65 2.37e-41 Pelvic organ prolapse (moderate/severe); CRC cis rs6951245 0.706 rs28483034 chr7:1170171 C/A cg26224354 chr7:1096374 C7orf50;GPR146 -0.82 -10.92 -0.52 6.85e-24 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs2692947 0.795 rs2252697 chr2:96778190 G/C cg23100626 chr2:96804247 ASTL -0.28 -7.76 -0.39 1.09e-13 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; CRC cis rs995000 0.868 rs9787151 chr1:63179138 C/T cg19896129 chr1:63156450 NA -0.43 -6.52 -0.34 2.67e-10 Triglyceride levels; CRC cis rs12410462 0.681 rs76191945 chr1:227673919 A/G cg04117972 chr1:227635322 NA 0.79 7.84 0.4 6.36e-14 Major depressive disorder; CRC cis rs56114371 0.568 rs200468 chr6:27757855 C/G cg20933634 chr6:27740509 NA 0.62 8.02 0.4 1.86e-14 Breast cancer; CRC cis rs2000999 0.725 rs12924886 chr16:72075593 A/T cg23815491 chr16:72088622 HP 0.58 6.2 0.32 1.73e-9 Total cholesterol levels;Cholesterol, total;Blood protein levels;LDL cholesterol levels;Haptoglobin levels;LDL cholesterol; CRC cis rs548181 0.545 rs1054997 chr11:125618813 G/A cg03464685 chr11:125439445 EI24 -1.02 -11.01 -0.52 3.24e-24 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs11122272 0.735 rs2790892 chr1:231512771 G/A cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.54 -8.11 -0.41 1.04e-14 Hemoglobin concentration; CRC cis rs9916302 0.904 rs8079303 chr17:37530755 G/C cg00129232 chr17:37814104 STARD3 0.53 7.96 0.4 2.76e-14 Glomerular filtration rate (creatinine); CRC cis rs801193 0.660 rs10950049 chr7:66230860 T/C cg00343986 chr7:65444356 GUSB 0.44 6.24 0.33 1.37e-9 Aortic root size; CRC cis rs7131987 0.650 rs7301188 chr12:29455391 C/T cg09582351 chr12:29534625 ERGIC2 -0.33 -7.11 -0.37 7.16e-12 QT interval; CRC cis rs600806 0.854 rs10745353 chr1:109877506 A/G cg23032129 chr1:109941072 SORT1 -0.28 -5.82 -0.31 1.37e-8 Intelligence (multi-trait analysis); CRC cis rs2769264 0.593 rs4971040 chr1:151366494 A/C cg18801370 chr1:151430492 POGZ 0.52 5.95 0.31 6.72e-9 Blood trace element (Cu levels); CRC cis rs6500395 0.963 rs2883642 chr16:48685146 C/T cg04672837 chr16:48644449 N4BP1 -0.45 -6.63 -0.34 1.38e-10 Response to tocilizumab in rheumatoid arthritis; CRC cis rs4481887 0.676 rs7527991 chr1:248527649 T/A cg26353448 chr1:248524236 OR2T4 -0.34 -6.9 -0.36 2.75e-11 Common traits (Other); CRC trans rs10155879 0.505 rs12704265 chr7:86142678 A/G cg26761047 chr1:15944228 DDI2 0.56 6.12 0.32 2.72e-9 Interleukin-4 levels; CRC cis rs853679 0.517 rs4713144 chr6:28106790 C/G cg15786705 chr6:28176104 NA 0.77 9.75 0.47 6.92e-20 Depression; CRC trans rs9858542 0.953 rs3811697 chr3:49590770 C/T cg21659725 chr3:3221576 CRBN -0.7 -9.64 -0.47 1.56e-19 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg25397718 chr9:140317786 EXD3;NOXA1 0.45 6.17 0.32 1.99e-9 Response to antipsychotic treatment; CRC trans rs1864585 0.520 rs73208781 chr8:10677498 A/C cg26278703 chr11:58910052 FAM111A 0.55 6.35 0.33 7.34e-10 Neutrophil percentage of white cells;Lymphocyte percentage of white cells; CRC cis rs763014 0.932 rs2269559 chr16:682297 T/C cg03804128 chr16:635623 NA 0.31 7.12 0.37 6.91e-12 Height; CRC cis rs1862618 0.802 rs33327 chr5:56142693 T/G cg24531977 chr5:56204891 C5orf35 -0.82 -10.96 -0.52 4.91e-24 Initial pursuit acceleration; CRC trans rs208520 0.690 rs207096 chr6:66797287 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.07 -15.42 -0.65 9.24e-41 Exhaled nitric oxide output; CRC cis rs9926296 0.542 rs12599531 chr16:89909401 C/T cg27121462 chr16:89883253 FANCA -0.39 -5.71 -0.3 2.55e-8 Vitiligo; CRC cis rs9549328 0.616 rs35086993 chr13:113617305 G/A cg20742385 chr13:113633654 MCF2L 0.56 9.53 0.46 3.7e-19 Systolic blood pressure; CRC cis rs2677744 0.626 rs11207 chr15:91497239 C/T cg23684204 chr15:91497937 RCCD1 0.43 6.49 0.34 3.13e-10 Attention deficit hyperactivity disorder; CRC cis rs514406 0.798 rs575138 chr1:53328394 C/G cg24675658 chr1:53192096 ZYG11B -0.65 -9.8 -0.48 4.44e-20 Monocyte count; CRC cis rs7100689 0.542 rs10887869 chr10:82194689 A/G cg00277334 chr10:82204260 NA -0.65 -10.46 -0.5 2.71e-22 Post bronchodilator FEV1; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg12933314 chr7:4815160 KIAA0415 0.45 6.4 0.33 5.29e-10 Response to antipsychotic treatment; CRC cis rs12711979 0.509 rs13005405 chr2:3826324 C/T cg17052675 chr2:3827356 NA -0.85 -20.99 -0.76 1.09e-62 Itch intensity from mosquito bite adjusted by bite size; CRC cis rs3849570 0.555 rs6790351 chr3:82008988 C/T cg07356753 chr3:81810745 GBE1 -0.49 -6.92 -0.36 2.39e-11 Waist circumference;Body mass index; CRC cis rs9443645 0.527 rs36128361 chr6:79684340 C/G cg09184832 chr6:79620586 NA -0.45 -7.7 -0.39 1.58e-13 Intelligence (multi-trait analysis); CRC cis rs1451375 0.669 rs59086818 chr7:50653830 G/A cg14593290 chr7:50529359 DDC 0.53 7.37 0.38 1.36e-12 Malaria; CRC cis rs501120 0.584 rs61855740 chr10:44679810 A/G cg09554077 chr10:44749378 NA 0.7 7.85 0.4 5.95e-14 Coronary artery disease;Coronary heart disease; CRC cis rs4862750 0.872 rs7679956 chr4:187900229 C/T cg22105103 chr4:187893119 NA 0.6 10.74 0.51 2.85e-23 Lobe attachment (rater-scored or self-reported); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg23679662 chr1:26633288 UBXN11 0.38 6.0 0.31 5.31e-9 Liver disease severity in Alagille syndrome; CRC cis rs11098699 0.718 rs13116874 chr4:124212211 T/C cg09941581 chr4:124220074 SPATA5 0.4 5.78 0.3 1.75e-8 Mosquito bite size; CRC trans rs2303319 0.504 rs12470743 chr2:162611202 G/A cg22627826 chr19:1240265 ATP5D -0.72 -6.24 -0.33 1.32e-9 Cognitive function; CRC cis rs1552244 0.935 rs6805869 chr3:10119917 T/C cg08888203 chr3:10149979 C3orf24 0.7 10.07 0.49 5.94e-21 Alzheimer's disease; CRC cis rs2075371 0.796 rs1646645 chr7:134012232 G/T cg11752832 chr7:134001865 SLC35B4 -0.46 -7.02 -0.36 1.26e-11 Mean platelet volume; CRC cis rs7552404 1.000 rs4646961 chr1:76217169 G/A cg22875332 chr1:76189707 ACADM 0.7 9.43 0.46 7.56e-19 Blood metabolite levels;Acylcarnitine levels; CRC cis rs611744 0.608 rs1448152 chr8:109278249 C/T cg21045802 chr8:109455806 TTC35 0.43 6.86 0.35 3.49e-11 Dupuytren's disease; CRC cis rs798554 0.660 rs798480 chr7:2805597 G/T cg17321639 chr7:2759063 NA -0.39 -5.6 -0.3 4.49e-8 Height; CRC cis rs7666738 0.830 rs2903154 chr4:99048151 A/G cg17366294 chr4:99064904 C4orf37 0.44 7.41 0.38 1.08e-12 Colonoscopy-negative controls vs population controls; CRC cis rs1451375 0.642 rs6963996 chr7:50559300 T/C cg14593290 chr7:50529359 DDC -0.64 -8.58 -0.43 3.92e-16 Malaria; CRC cis rs3096299 0.685 rs12446145 chr16:89542695 C/T cg01788221 chr16:89496183 ANKRD11 -0.39 -5.72 -0.3 2.44e-8 Multiple myeloma (IgH translocation); CRC cis rs56176327 0.583 rs7613603 chr3:49812866 C/T cg03060546 chr3:49711283 APEH -0.65 -7.89 -0.4 4.42e-14 Intelligence (multi-trait analysis); CRC cis rs1218582 0.688 rs2135219 chr1:154857217 G/A cg03351412 chr1:154909251 PMVK 0.5 7.1 0.36 7.98e-12 Prostate cancer; CRC cis rs6500395 1.000 rs3848322 chr16:48620964 C/A cg04672837 chr16:48644449 N4BP1 0.44 6.53 0.34 2.51e-10 Response to tocilizumab in rheumatoid arthritis; CRC cis rs734999 0.545 rs12752515 chr1:2564465 T/C cg18854424 chr1:2615690 NA -0.4 -7.52 -0.38 5.37e-13 Ulcerative colitis; CRC cis rs9303401 0.704 rs7359501 chr17:56641200 C/T cg12560992 chr17:57184187 TRIM37 0.57 8.41 0.42 1.23e-15 Cognitive test performance; CRC cis rs10504229 0.683 rs72650847 chr8:58136825 C/T cg02290350 chr8:58132656 NA -0.59 -6.84 -0.35 3.91e-11 Developmental language disorder (linguistic errors); CRC cis rs35264875 1.000 rs72928644 chr11:68849845 A/G cg03469862 chr11:68924853 NA 0.46 5.91 0.31 8.56e-9 Blond vs. brown hair color; CRC cis rs6912958 0.781 rs7761814 chr6:88188309 G/A cg08069147 chr6:88032118 GJB7;C6orf162 -0.55 -8.25 -0.41 3.93e-15 Monocyte percentage of white cells; CRC cis rs7312933 0.558 rs1796381 chr12:42842475 C/T cg19980929 chr12:42632907 YAF2 0.38 5.92 0.31 8e-9 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg09010904 chr3:51573036 NA 0.4 6.19 0.32 1.83e-9 Obesity-related traits; CRC cis rs7666738 0.830 rs13129503 chr4:98987892 T/C cg17366294 chr4:99064904 C4orf37 0.43 7.33 0.37 1.76e-12 Colonoscopy-negative controls vs population controls; CRC cis rs2243480 1.000 rs316332 chr7:65604299 A/G cg25985355 chr7:65971099 NA -0.52 -6.0 -0.31 5.15e-9 Diabetic kidney disease; CRC cis rs200986 1 rs200986 chr6:27824766 G/C cg12172441 chr6:28176163 NA 0.52 7.1 0.36 7.87e-12 Autism spectrum disorder or schizophrenia; CRC cis rs8060686 0.565 rs11555011 chr16:68088485 A/G cg26727032 chr16:67993705 SLC12A4 -0.59 -6.7 -0.35 9.01e-11 HDL cholesterol;Metabolic syndrome; CRC cis rs4713118 0.586 rs9468290 chr6:28087674 C/T cg12273811 chr6:28175739 NA 0.73 9.18 0.45 4.85e-18 Parkinson's disease; CRC cis rs853679 0.506 rs1150693 chr6:28174590 T/C cg02683197 chr6:28174875 NA 0.83 11.13 0.52 1.19e-24 Depression; CRC cis rs9311474 0.502 rs4687624 chr3:52563572 C/T cg15147215 chr3:52552868 STAB1 -0.65 -11.41 -0.53 1.28e-25 Electroencephalogram traits; CRC cis rs6502050 0.835 rs34620191 chr17:80149532 G/A cg25804541 chr17:80189381 SLC16A3 -0.31 -5.9 -0.31 8.81e-9 Life satisfaction; CRC cis rs9487051 0.933 rs5005289 chr6:109617673 C/G cg12927641 chr6:109611667 NA -0.32 -5.62 -0.3 3.97e-8 Reticulocyte fraction of red cells; CRC cis rs950776 0.518 rs12914694 chr15:78814444 G/A cg06917634 chr15:78832804 PSMA4 0.65 10.21 0.49 1.97e-21 Sudden cardiac arrest; CRC cis rs28386778 0.897 rs6504185 chr17:61848792 A/G cg22520471 chr17:61851767 DDX42;CCDC47 0.74 11.57 0.54 3.22e-26 Prudent dietary pattern; CRC cis rs875971 0.638 rs6460305 chr7:66060408 G/A cg18876405 chr7:65276391 NA -0.61 -11.07 -0.52 1.96e-24 Aortic root size; CRC cis rs6933660 0.665 rs6921042 chr6:151732385 T/C cg14416726 chr6:151773293 C6orf211;RMND1 -0.58 -8.85 -0.44 5.66e-17 Menarche (age at onset); CRC cis rs6674176 0.660 rs2108202 chr1:44395786 A/G cg12908607 chr1:44402522 ARTN 0.61 11.12 0.52 1.31e-24 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Cognitive ability; CRC cis rs6662572 0.737 rs56047133 chr1:46517228 C/T cg08644498 chr1:46502608 NA 0.47 7.43 0.38 9.19e-13 Blood protein levels; CRC cis rs7527798 0.501 rs12125256 chr1:207851361 C/T cg09232269 chr1:207846808 CR1L -0.47 -7.66 -0.39 2.12e-13 Erythrocyte sedimentation rate; CRC cis rs2273669 0.915 rs10872028 chr6:109313728 A/G cg05315195 chr6:109294784 ARMC2 0.49 5.65 0.3 3.55e-8 Prostate cancer; CRC cis rs2346177 0.638 rs34186951 chr2:46657659 A/G cg26688816 chr2:46740690 ATP6V1E2 -0.6 -9.8 -0.48 4.66e-20 HDL cholesterol; CRC trans rs5756813 0.635 rs12160750 chr22:38199054 A/G cg19894588 chr14:64061835 NA -0.62 -8.41 -0.42 1.3e-15 Optic cup area;Vertical cup-disc ratio; CRC cis rs728616 0.867 rs55666905 chr10:81953639 C/T cg11900509 chr10:81946545 ANXA11 -0.76 -7.36 -0.38 1.46e-12 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs2303745 0.589 rs6512182 chr19:17399476 G/T cg15110403 chr19:17392923 ANKLE1 -0.36 -5.75 -0.3 1.99e-8 Systemic lupus erythematosus; CRC cis rs1153858 1.000 rs60476496 chr15:45713801 C/T cg21132104 chr15:45694354 SPATA5L1 0.6 8.47 0.42 8.52e-16 Homoarginine levels; CRC cis rs2070488 1.000 rs2276540 chr3:38512507 G/A cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.91 17.03 0.68 4.35e-47 Electrocardiographic conduction measures; CRC cis rs977987 0.835 rs4888380 chr16:75347690 T/C cg03315344 chr16:75512273 CHST6 0.52 8.8 0.44 7.76e-17 Dupuytren's disease; CRC trans rs8073060 0.518 rs225285 chr17:33931084 G/C cg19694781 chr19:47549865 TMEM160 -0.72 -10.71 -0.51 3.76e-23 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; CRC cis rs1218582 0.600 rs72702224 chr1:154911689 G/A cg06221963 chr1:154839813 KCNN3 -0.78 -13.78 -0.61 1.99e-34 Prostate cancer; CRC cis rs9393777 0.841 rs67092078 chr6:27054772 G/A cg16898833 chr6:26189333 HIST1H4D 0.91 6.45 0.34 4e-10 Intelligence (multi-trait analysis); CRC cis rs4713118 0.513 rs156738 chr6:28014025 G/C cg06470822 chr6:28175283 NA 0.8 11.94 0.55 1.56e-27 Parkinson's disease; CRC cis rs6089584 0.888 rs6061981 chr20:60618973 T/C cg23463467 chr20:60627584 TAF4 0.33 5.71 0.3 2.53e-8 Body mass index; CRC cis rs2840044 1.000 rs1671656 chr17:33939661 C/T cg05299278 chr17:33885742 SLFN14 0.4 6.06 0.32 3.73e-9 Response to radiotherapy in cancer (late toxicity); CRC cis rs514406 0.825 rs487453 chr1:53271225 T/C cg25767906 chr1:53392781 SCP2 0.41 6.75 0.35 6.6e-11 Monocyte count; CRC cis rs9911578 1.000 rs302859 chr17:56693132 C/T cg05425664 chr17:57184151 TRIM37 -0.5 -7.92 -0.4 3.69e-14 Intelligence (multi-trait analysis); CRC cis rs55823223 0.564 rs936396 chr17:73846829 C/G cg08125733 chr17:73851984 WBP2 0.73 9.39 0.46 1.04e-18 Psoriasis; CRC cis rs5753618 0.561 rs2283881 chr22:31638932 G/A cg07713946 chr22:31675144 LIMK2 -0.39 -5.6 -0.3 4.42e-8 Colorectal cancer; CRC cis rs711245 0.518 rs11886145 chr2:36825716 C/G cg15105969 chr2:36825350 FEZ2 0.57 8.04 0.41 1.6e-14 Height; CRC cis rs6502050 0.764 rs35416122 chr17:80119006 A/G cg25804541 chr17:80189381 SLC16A3 -0.31 -5.95 -0.31 6.84e-9 Life satisfaction; CRC cis rs514406 0.861 rs2448792 chr1:53268313 T/C cg27535305 chr1:53392650 SCP2 0.39 7.01 0.36 1.34e-11 Monocyte count; CRC cis rs1451375 0.550 rs10239830 chr7:50603829 A/G cg18232548 chr7:50535776 DDC 0.47 6.1 0.32 3e-9 Malaria; CRC cis rs763121 0.853 rs4821808 chr22:39065739 A/G cg06544989 chr22:39130855 UNC84B 0.46 7.17 0.37 5.11e-12 Menopause (age at onset); CRC cis rs10744422 0.920 rs897393 chr12:123312051 A/G cg25930673 chr12:123319894 HIP1R 0.52 5.71 0.3 2.54e-8 Schizophrenia; CRC cis rs2012796 0.957 rs8009083 chr14:81818289 A/G cg02996355 chr14:81879375 NA 0.5 7.54 0.38 4.52e-13 Night sleep phenotypes; CRC cis rs2204008 0.640 rs11520199 chr12:38211026 T/C cg26384229 chr12:38710491 ALG10B 0.69 9.26 0.45 2.81e-18 Bladder cancer; CRC cis rs870825 0.929 rs55635512 chr4:185589982 G/T cg04058563 chr4:185651563 MLF1IP 0.58 6.08 0.32 3.27e-9 Blood protein levels; CRC cis rs6424115 1.000 rs12116511 chr1:24162662 A/G cg10978503 chr1:24200527 CNR2 -0.51 -9.08 -0.45 9.99e-18 Immature fraction of reticulocytes; CRC cis rs2463822 0.583 rs17709552 chr11:62040519 A/G cg06239285 chr11:62104954 ASRGL1 -0.73 -7.66 -0.39 2.04e-13 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs17376456 0.825 rs74825443 chr5:93254973 T/C cg21475434 chr5:93447410 FAM172A 0.83 8.24 0.41 4.04e-15 Diabetic retinopathy; CRC cis rs2243480 1.000 rs13235972 chr7:65883605 C/T cg12463550 chr7:65579703 CRCP 0.7 6.26 0.33 1.22e-9 Diabetic kidney disease; CRC cis rs2120019 0.938 rs8028632 chr15:75321262 T/C cg11632617 chr15:75315747 PPCDC -0.57 -7.79 -0.39 8.82e-14 Blood trace element (Zn levels); CRC cis rs62064224 0.714 rs11653974 chr17:30635002 T/C cg21839984 chr17:30846986 MYO1D -0.34 -5.89 -0.31 9.69e-9 Schizophrenia; CRC cis rs3820068 0.603 rs67349836 chr1:15966176 T/C cg13390004 chr1:15929781 NA 0.45 6.47 0.34 3.61e-10 Systolic blood pressure; CRC cis rs9811920 0.609 rs6440938 chr3:99652092 T/C cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G -0.46 -6.18 -0.32 1.87e-9 Axial length; CRC cis rs7927592 0.912 rs55767696 chr11:68375120 C/G cg01657329 chr11:68192670 LRP5 -0.48 -7.02 -0.36 1.28e-11 Total body bone mineral density; CRC cis rs9372498 0.536 rs9489436 chr6:118873817 A/C cg18833306 chr6:118973337 C6orf204 0.45 5.95 0.31 6.95e-9 Diastolic blood pressure; CRC cis rs2249694 0.919 rs11101867 chr10:135400250 C/T cg20169779 chr10:135381914 SYCE1 -0.62 -10.38 -0.5 4.87e-22 Obesity-related traits; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg26307797 chr11:130446613 NA 0.38 6.14 0.32 2.36e-9 Liver disease severity in Alagille syndrome; CRC cis rs2274273 0.638 rs67416413 chr14:55702263 A/G cg10130446 chr14:55658398 DLGAP5 -0.44 -5.87 -0.31 1.06e-8 Protein biomarker; CRC cis rs853679 0.517 rs9283884 chr6:28135660 C/G cg21251018 chr6:28226885 NKAPL -0.46 -5.85 -0.31 1.19e-8 Depression; CRC cis rs2576037 0.526 rs605487 chr18:44444778 G/C cg19077165 chr18:44547161 KATNAL2 -0.6 -10.06 -0.49 6.09e-21 Personality dimensions; CRC cis rs9818941 1.000 rs7429574 chr3:157703589 G/A cg08654915 chr3:157813417 NA -0.32 -5.98 -0.31 5.73e-9 Height; CRC cis rs17376456 0.504 rs6898507 chr5:93082343 C/T cg25358565 chr5:93447407 FAM172A 0.62 7.23 0.37 3.4e-12 Diabetic retinopathy; CRC cis rs10512697 0.655 rs35573920 chr5:3486281 C/T cg19473799 chr5:3511975 NA -0.83 -6.35 -0.33 7.32e-10 Immune response to smallpox vaccine (IL-6); CRC cis rs1992660 0.528 rs12655827 chr5:40412335 C/T cg09067459 chr5:40385259 NA -0.42 -7.09 -0.36 8.27e-12 Crohn's disease; CRC cis rs6121246 0.559 rs6060599 chr20:30257754 T/G cg13852791 chr20:30311386 BCL2L1 0.71 13.57 0.6 1.23e-33 Mean corpuscular hemoglobin; CRC cis rs896854 0.967 rs10808671 chr8:95967372 A/G cg09323728 chr8:95962352 TP53INP1 -0.44 -7.26 -0.37 2.89e-12 Type 2 diabetes; CRC cis rs10888329 0.819 rs7521717 chr1:248370463 T/A cg00666640 chr1:248458726 OR2T12 0.43 6.83 0.35 4e-11 Autism spectrum disorder; CRC cis rs7215564 0.730 rs76584516 chr17:78549237 A/G cg09596252 chr17:78655493 RPTOR 0.61 5.79 0.3 1.68e-8 Myopia (pathological); CRC cis rs11098499 0.754 rs34425882 chr4:120253177 G/A cg09307838 chr4:120376055 NA 0.61 9.59 0.47 2.22e-19 Corneal astigmatism; CRC cis rs853679 0.517 rs9380055 chr6:28081629 A/G cg02683197 chr6:28174875 NA 0.85 10.27 0.49 1.16e-21 Depression; CRC cis rs7274811 0.723 rs6120329 chr20:32210238 T/G cg03904042 chr20:32255491 NECAB3;C20orf134 -0.45 -6.24 -0.33 1.33e-9 Height; CRC cis rs2836950 0.520 rs1980407 chr21:40543961 T/C cg17971929 chr21:40555470 PSMG1 -0.6 -8.81 -0.44 7.55e-17 Menarche (age at onset); CRC cis rs11690935 0.851 rs7581072 chr2:172859849 C/T cg13550731 chr2:172543902 DYNC1I2 -0.99 -15.34 -0.65 1.9e-40 Schizophrenia; CRC cis rs554111 0.891 rs604645 chr1:21043926 T/C cg08890418 chr1:21044141 KIF17 0.33 5.91 0.31 8.65e-9 Facial morphology (factor 17, height of vermillion upper lip); CRC cis rs7666738 0.830 rs9994346 chr4:99037986 A/G cg17366294 chr4:99064904 C4orf37 0.44 7.39 0.38 1.24e-12 Colonoscopy-negative controls vs population controls; CRC cis rs1448094 0.872 rs7305869 chr12:86440114 A/G cg18827107 chr12:86230957 RASSF9 -0.37 -5.88 -0.31 1.01e-8 Major depressive disorder; CRC cis rs585510 1 rs585510 chr12:121000133 A/G cg12219531 chr12:120966889 COQ5 0.69 9.18 0.45 4.98e-18 Reticulocyte fraction of red cells; CRC cis rs17095355 1.000 rs12570607 chr10:111696704 C/A cg00817464 chr10:111662876 XPNPEP1 -0.61 -8.24 -0.41 4.12e-15 Biliary atresia; CRC cis rs1448094 0.533 rs10863078 chr12:86152672 C/T cg19622623 chr12:86230825 RASSF9 0.38 5.81 0.31 1.46e-8 Major depressive disorder; CRC cis rs9291683 0.595 rs3733585 chr4:10036339 A/G cg11266682 chr4:10021025 SLC2A9 0.53 11.09 0.52 1.78e-24 Bone mineral density; CRC cis rs4970988 0.787 rs1532770 chr1:150725335 G/T cg17724175 chr1:150552817 MCL1 0.49 7.15 0.37 5.51e-12 Urate levels; CRC cis rs10504229 1.000 rs67105789 chr8:58192002 G/T cg01721255 chr8:58191610 C8orf71 0.49 6.17 0.32 2e-9 Developmental language disorder (linguistic errors); CRC cis rs4819052 0.819 rs8134084 chr21:46693295 G/A cg19498844 chr21:46707878 POFUT2;LOC642852 0.79 11.53 0.54 4.72e-26 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs2635047 0.935 rs2461247 chr18:44698537 T/G cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.42 6.72 0.35 8.03e-11 Educational attainment; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg09485063 chr2:75107440 HK2 -0.37 -5.98 -0.31 5.91e-9 Liver disease severity in Alagille syndrome; CRC trans rs853679 0.546 rs200995 chr6:27813694 C/T cg06606381 chr12:133084897 FBRSL1 0.75 6.49 0.34 3.15e-10 Depression; CRC cis rs7777484 0.571 rs2527686 chr7:2834413 G/A cg19717773 chr7:2847554 GNA12 -0.48 -8.46 -0.42 9.03e-16 Height; CRC cis rs2243480 1.000 rs2961102 chr7:65424658 A/G cg12463550 chr7:65579703 CRCP 0.66 6.26 0.33 1.2e-9 Diabetic kidney disease; CRC cis rs10971721 0.822 rs10971794 chr9:33924312 G/A cg13495928 chr9:33750294 PRSS3 0.56 5.97 0.31 6.15e-9 Body mass index; CRC cis rs4727027 0.866 rs35599790 chr7:148806012 C/T cg23583168 chr7:148888333 NA -0.89 -14.85 -0.63 1.6e-38 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC cis rs2952156 0.920 rs8078228 chr17:37834998 C/T cg11212589 chr17:38028394 ZPBP2 0.35 6.15 0.32 2.26e-9 Asthma; CRC cis rs72615157 0.595 rs112241539 chr7:99847237 C/T cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.59 6.6 0.34 1.64e-10 Lung function (FEV1/FVC); CRC cis rs9733 0.596 rs12063547 chr1:150674053 G/T cg10589385 chr1:150898437 SETDB1 -0.29 -6.16 -0.32 2.18e-9 Tonsillectomy; CRC cis rs11166629 1.000 rs6992668 chr8:135645129 T/C cg27224718 chr8:135614730 ZFAT 0.53 7.77 0.39 1.02e-13 Smoking quantity; CRC cis rs4319547 0.656 rs7294559 chr12:122837564 C/A cg05707623 chr12:122985044 ZCCHC8 -0.72 -8.76 -0.43 1.07e-16 Body mass index; CRC cis rs10870270 1.000 rs72636963 chr10:133771271 C/T cg08754478 chr10:133766260 PPP2R2D -0.67 -9.29 -0.46 2.24e-18 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; CRC cis rs7959452 0.530 rs12811632 chr12:69755003 G/A cg22834771 chr12:69754056 YEATS4 -0.5 -7.34 -0.38 1.68e-12 Blood protein levels; CRC cis rs7552404 0.727 rs6678348 chr1:76332463 C/T cg05598546 chr1:76251766 SNORD45C;RABGGTB 0.52 5.79 0.3 1.69e-8 Blood metabolite levels;Acylcarnitine levels; CRC cis rs1577917 0.682 rs1173419 chr6:86402163 A/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.6 -8.38 -0.42 1.6e-15 Response to antipsychotic treatment; CRC cis rs2762353 0.595 rs13194155 chr6:25755508 C/T cg07061783 chr6:25882402 NA 0.5 6.39 0.33 5.67e-10 Blood metabolite levels; CRC cis rs1572438 0.862 rs9406075 chr6:856361 A/G cg13447295 chr6:887704 NA -0.42 -6.12 -0.32 2.6e-9 Aging; CRC cis rs7618501 0.633 rs9861216 chr3:50059339 A/G cg24110177 chr3:50126178 RBM5 0.51 7.89 0.4 4.64e-14 Intelligence (multi-trait analysis); CRC trans rs637571 0.584 rs594689 chr11:65635559 G/A cg17712092 chr4:129076599 LARP1B -0.58 -9.03 -0.45 1.52e-17 Eosinophil percentage of white cells; CRC cis rs870825 0.655 rs28661636 chr4:185634218 A/C cg04058563 chr4:185651563 MLF1IP 0.73 9.38 0.46 1.13e-18 Blood protein levels; CRC cis rs6546324 0.625 rs6730286 chr2:67848054 C/T cg15745817 chr2:67799979 NA -0.55 -9.5 -0.46 4.36e-19 Endometriosis; CRC cis rs17152411 0.947 rs55674450 chr10:126592153 G/T cg07906193 chr10:126599966 NA 0.59 6.74 0.35 6.98e-11 Height; CRC cis rs394563 0.591 rs11155641 chr6:149648595 G/A cg03678062 chr6:149772716 ZC3H12D 0.35 6.34 0.33 7.43e-10 Dupuytren's disease; CRC cis rs1448094 0.781 rs7959093 chr12:86335502 C/A cg25456477 chr12:86230367 RASSF9 0.34 5.71 0.3 2.5e-8 Major depressive disorder; CRC cis rs12477438 0.666 rs10179910 chr2:99658503 A/C cg14399236 chr2:99771627 LIPT1;TSGA10 -0.56 -7.42 -0.38 1.01e-12 Chronic sinus infection; CRC cis rs13191362 1.000 rs2156257 chr6:163100710 G/T cg06582575 chr6:163149167 PACRG;PARK2 0.93 11.85 0.55 3.25e-27 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs897984 0.806 rs12928852 chr16:30943988 C/T cg02466173 chr16:30829666 NA 0.66 10.0 0.48 1.02e-20 Dementia with Lewy bodies; CRC cis rs1005224 0.819 rs10147492 chr14:76155309 T/G cg04684003 chr14:76127793 TTLL5;C14orf1 -0.48 -6.94 -0.36 2.13e-11 Large artery stroke; CRC cis rs10208940 0.920 rs10211211 chr2:68718191 G/C cg12452813 chr2:68675892 NA 0.51 6.35 0.33 7.33e-10 Urate levels in lean individuals; CRC cis rs514406 0.929 rs12354395 chr1:53327663 A/G cg27535305 chr1:53392650 SCP2 -0.37 -6.77 -0.35 5.99e-11 Monocyte count; CRC trans rs2303319 0.582 rs62187614 chr2:162436285 C/G cg14875682 chr5:52083620 ITGA1;PELO -0.75 -6.01 -0.31 5.03e-9 Cognitive function; CRC cis rs73206853 0.764 rs73194012 chr12:111100627 T/C cg12870014 chr12:110450643 ANKRD13A 0.87 10.08 0.49 5.28e-21 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC cis rs62432291 0.681 rs436277 chr6:159634142 G/A cg14500486 chr6:159655392 FNDC1 0.8 10.62 0.51 7.3e-23 Joint mobility (Beighton score); CRC cis rs684232 0.602 rs2543775 chr17:557123 G/A cg15660573 chr17:549704 VPS53 -0.87 -15.78 -0.66 3.72e-42 Prostate cancer; CRC cis rs3857536 0.776 rs9294687 chr6:66942919 C/T cg07460842 chr6:66804631 NA -0.43 -5.78 -0.3 1.72e-8 Blood trace element (Cu levels); CRC cis rs929354 1.000 rs1182385 chr7:157040583 C/T cg17757837 chr7:157058334 UBE3C -0.8 -14.82 -0.63 1.98e-38 Body mass index; CRC trans rs561341 0.700 rs8079471 chr17:30218317 A/G cg20587970 chr11:113659929 NA -0.52 -7.06 -0.36 9.84e-12 Hip circumference adjusted for BMI; CRC cis rs6121246 0.559 rs10439608 chr20:30258814 T/C cg13852791 chr20:30311386 BCL2L1 0.74 14.67 0.63 7.5e-38 Mean corpuscular hemoglobin; CRC cis rs7937682 0.921 rs7130753 chr11:111470567 C/T cg09085632 chr11:111637200 PPP2R1B 1.01 15.86 0.66 1.73e-42 Primary sclerosing cholangitis; CRC cis rs1018836 0.847 rs4735225 chr8:91569100 G/C cg16814680 chr8:91681699 NA -0.74 -11.74 -0.54 8.38e-27 Ejection fraction in Tripanosoma cruzi seropositivity; CRC cis rs2688608 0.901 rs2633312 chr10:75631755 T/A cg00564723 chr10:75632066 CAMK2G -0.22 -5.66 -0.3 3.32e-8 Inflammatory bowel disease; CRC cis rs10046574 0.561 rs13438700 chr7:135207626 C/A cg27474649 chr7:135195673 CNOT4 0.61 5.95 0.31 7.03e-9 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs3785574 0.962 rs2665842 chr17:61878535 G/A cg23090583 chr17:61904693 PSMC5;FTSJ3 0.66 9.59 0.47 2.2e-19 Height; CRC cis rs11690935 0.550 rs55653103 chr2:172861816 T/C cg13550731 chr2:172543902 DYNC1I2 0.65 9.35 0.46 1.42e-18 Schizophrenia; CRC cis rs10504229 1.000 rs67388517 chr8:58176617 C/A cg24829409 chr8:58192753 C8orf71 -0.68 -11.34 -0.53 2.27e-25 Developmental language disorder (linguistic errors); CRC cis rs1472360 0.505 rs1496527 chr8:86273696 G/A cg21346043 chr8:86351067 CA3 -0.38 -6.28 -0.33 1.1e-9 Mean corpuscular hemoglobin concentration; CRC cis rs7666738 0.618 rs10856932 chr4:98819992 C/T cg17366294 chr4:99064904 C4orf37 0.43 6.94 0.36 2.11e-11 Colonoscopy-negative controls vs population controls; CRC cis rs4713118 0.824 rs13211701 chr6:27750079 T/C cg08798685 chr6:27730294 NA -0.48 -6.66 -0.34 1.12e-10 Parkinson's disease; CRC cis rs17065868 0.764 rs41425048 chr13:45026729 C/T cg10246903 chr13:45222710 NA -0.54 -5.81 -0.3 1.51e-8 Antineutrophil cytoplasmic antibody-associated vasculitis; CRC cis rs2227564 0.620 rs10740418 chr10:75519322 T/C cg16540259 chr10:75572220 NDST2 0.51 7.81 0.4 7.58e-14 Crohn's disease;Inflammatory bowel disease; CRC cis rs4920343 0.698 rs573966 chr1:19087828 A/G cg19637330 chr1:19110922 NA 0.39 5.85 0.31 1.21e-8 Knee osteoarthritis; CRC cis rs1153858 0.943 rs8038342 chr15:45651537 T/C cg10760299 chr15:45669010 GATM 0.52 8.29 0.42 2.96e-15 Homoarginine levels; CRC cis rs34330 0.562 rs11055023 chr12:12853197 A/G cg04607235 chr12:12878440 APOLD1 -0.71 -7.19 -0.37 4.26e-12 Systemic lupus erythematosus; CRC cis rs4689388 0.889 rs4629534 chr4:6294124 G/T cg14416269 chr4:6271139 WFS1 0.4 6.6 0.34 1.62e-10 Type 2 diabetes and other traits;Type 2 diabetes; CRC cis rs67340775 0.541 rs200974 chr6:27855845 A/G cg12273811 chr6:28175739 NA 0.58 5.98 0.31 5.69e-9 Lung cancer in ever smokers; CRC cis rs35995292 0.534 rs10274968 chr7:38939254 C/T cg19327137 chr7:38886074 VPS41 0.68 11.62 0.54 2.22e-26 Subjective well-being (multi-trait analysis); CRC cis rs9911578 1.000 rs1472288 chr17:56910720 G/A cg05425664 chr17:57184151 TRIM37 -0.49 -7.72 -0.39 1.45e-13 Intelligence (multi-trait analysis); CRC cis rs12410462 0.901 rs1120000 chr1:227659615 T/C cg23173402 chr1:227635558 NA 0.61 7.19 0.37 4.29e-12 Major depressive disorder; CRC cis rs637571 0.522 rs3016868 chr11:65764383 C/T cg26695010 chr11:65641043 EFEMP2 -0.4 -6.05 -0.32 4.05e-9 Eosinophil percentage of white cells; CRC cis rs524281 0.773 rs10750781 chr11:66037270 A/G cg14036092 chr11:66035641 RAB1B -0.56 -6.13 -0.32 2.56e-9 Electroencephalogram traits; CRC cis rs6952808 0.723 rs4721264 chr7:2012997 G/A cg04267008 chr7:1944627 MAD1L1 -0.77 -11.01 -0.52 3.24e-24 Bipolar disorder and schizophrenia; CRC cis rs13191362 0.938 rs13192618 chr6:163132822 T/C cg23758597 chr6:163146217 PARK2 -0.65 -6.74 -0.35 6.95e-11 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs2688608 0.592 rs12253429 chr10:75496161 C/G cg16540259 chr10:75572220 NDST2 0.38 5.91 0.31 8.5e-9 Inflammatory bowel disease; CRC cis rs9768139 0.733 rs34173461 chr7:158122175 C/G cg24154853 chr7:158122151 PTPRN2 0.65 10.75 0.51 2.67e-23 Calcium levels; CRC cis rs7312933 0.524 rs11181465 chr12:42765098 T/G cg11827402 chr12:42719852 PPHLN1;ZCRB1 0.67 9.79 0.48 4.91e-20 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CRC cis rs7666738 0.830 rs28451001 chr4:98924544 T/A cg05340658 chr4:99064831 C4orf37 0.6 9.35 0.46 1.41e-18 Colonoscopy-negative controls vs population controls; CRC cis rs6089584 0.830 rs4925331 chr20:60580174 T/C cg23262073 chr20:60523788 NA -0.41 -6.91 -0.36 2.47e-11 Body mass index; CRC cis rs812925 0.502 rs6545868 chr2:61655365 T/C cg10580144 chr2:61372316 C2orf74 -0.31 -6.59 -0.34 1.73e-10 Immature fraction of reticulocytes; CRC cis rs1552244 0.882 rs67895180 chr3:10026079 T/C cg10729496 chr3:10149963 C3orf24 0.48 6.25 0.33 1.25e-9 Alzheimer's disease; CRC trans rs1814175 0.817 rs3974439 chr11:50022607 G/A cg11707556 chr5:10655725 ANKRD33B -0.43 -8.45 -0.42 9.43e-16 Height; CRC cis rs294883 0.739 rs62438586 chr6:159730272 C/T cg14500486 chr6:159655392 FNDC1 -0.36 -6.19 -0.32 1.81e-9 Coronary artery disease; CRC cis rs853679 0.517 rs9380049 chr6:28048535 A/G cg23161317 chr6:28129485 ZNF389 0.52 6.4 0.33 5.21e-10 Depression; CRC trans rs4087296 0.502 rs2906804 chr16:82335001 C/T cg09652807 chr17:2652918 MIR1253 0.54 5.99 0.31 5.51e-9 Bone mineral density; CRC cis rs1178968 0.901 rs1178970 chr7:72750345 G/A cg25889504 chr7:72793014 NA 0.51 5.93 0.31 7.62e-9 Triglyceride levels; CRC cis rs9926296 0.572 rs2079671 chr16:89884981 T/C cg03605463 chr16:89740564 NA -0.42 -6.24 -0.33 1.31e-9 Vitiligo; CRC cis rs7666738 0.830 rs13112037 chr4:98976986 A/T cg05340658 chr4:99064831 C4orf37 0.6 9.35 0.46 1.41e-18 Colonoscopy-negative controls vs population controls; CRC trans rs11212617 0.805 rs10890821 chr11:108022061 A/T cg01883757 chr16:56815826 NUP93 0.39 6.11 0.32 2.87e-9 Response to metformin in type 2 diabetes (glycemic); CRC cis rs12900413 0.687 rs12913409 chr15:90319251 T/A cg24249390 chr15:90295951 MESP1 -0.6 -9.49 -0.46 4.94e-19 Coronary artery aneurysm in Kawasaki disease; CRC trans rs1997103 0.863 rs4480062 chr7:55401299 T/C cg20935933 chr6:143382018 AIG1 0.52 6.72 0.35 7.8e-11 QRS interval (sulfonylurea treatment interaction); CRC cis rs6089584 0.566 rs2181589 chr20:60622817 C/T cg06108461 chr20:60628389 TAF4 0.73 12.88 0.58 5.32e-31 Body mass index; CRC cis rs853679 1.000 rs9986596 chr6:28219661 G/A cg06470822 chr6:28175283 NA 0.72 6.95 0.36 1.92e-11 Depression; CRC cis rs7249142 0.549 rs12975253 chr19:19279745 A/C cg08207377 chr19:19281140 LOC729991-MEF2B;MEF2B -0.38 -6.2 -0.32 1.71e-9 IgG glycosylation; CRC cis rs6088590 0.561 rs6087600 chr20:33157217 T/C cg24642439 chr20:33292090 TP53INP2 0.4 6.89 0.36 2.77e-11 Coronary artery disease; CRC cis rs7493 0.950 rs12704794 chr7:95036133 A/T cg19678392 chr7:94953810 PON1 -0.57 -7.2 -0.37 4.21e-12 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs589448 0.967 rs2617835 chr12:69753420 C/A cg14784868 chr12:69753453 YEATS4 0.91 17.35 0.69 2.44e-48 Cerebrospinal fluid biomarker levels; CRC cis rs875971 0.964 rs1643388 chr7:65844562 T/C cg00343986 chr7:65444356 GUSB 0.43 6.3 0.33 9.66e-10 Aortic root size; CRC cis rs7766641 1 rs7766641 chr6:26184102 G/A cg00631329 chr6:26305371 NA -0.48 -7.56 -0.38 4.03e-13 Height; CRC cis rs3796352 1.000 rs11718834 chr3:52963668 A/C cg27565382 chr3:53032988 SFMBT1 0.67 5.97 0.31 6.2e-9 Immune reponse to smallpox (secreted IL-2); CRC cis rs10504229 0.861 rs116923397 chr8:58185162 T/G cg24829409 chr8:58192753 C8orf71 -0.68 -11.28 -0.53 3.63e-25 Developmental language disorder (linguistic errors); CRC cis rs2180341 0.814 rs6569488 chr6:127726256 C/T cg24812749 chr6:127587940 RNF146 0.67 9.13 0.45 7.3e-18 Breast cancer; CRC cis rs8180040 0.620 rs2278963 chr3:47054869 G/T cg02527881 chr3:46936655 PTH1R 0.34 5.88 0.31 1.03e-8 Colorectal cancer; CRC trans rs7395662 1.000 rs11039779 chr11:48517895 G/A cg21153622 chr11:89784906 NA -0.44 -7.1 -0.36 7.5e-12 HDL cholesterol; CRC cis rs6540556 0.679 rs11808690 chr1:209891450 T/G cg05527609 chr1:210001259 C1orf107 -0.55 -6.0 -0.31 5.1e-9 Red blood cell count; CRC cis rs17345786 0.861 rs17402964 chr3:101067945 C/T cg11279151 chr3:101281821 RG9MTD1 -0.66 -8.12 -0.41 9.74e-15 Colonoscopy-negative controls vs population controls; CRC cis rs847649 0.699 rs10271157 chr7:102527591 A/G cg18108683 chr7:102477205 FBXL13 -0.63 -11.01 -0.52 3.37e-24 Morning vs. evening chronotype; CRC cis rs968567 0.528 rs174582 chr11:61607168 A/G cg19610905 chr11:61596333 FADS2 -0.44 -5.69 -0.3 2.84e-8 Blood metabolite levels;Rheumatoid arthritis;Vitiligo;Glycerophospholipid levels; CRC cis rs681343 1.000 rs681343 chr19:49206462 C/T cg01656853 chr19:49199172 FUT2 0.23 5.68 0.3 2.89e-8 Lung adenocarcinoma;Primary sclerosing cholangitis;Childhood ear infection; CRC cis rs10896135 0.554 rs3741364 chr11:66451178 C/T cg24851651 chr11:66362959 CCS 0.42 5.85 0.31 1.2e-8 Bipolar disorder; CRC cis rs9847710 0.733 rs9818819 chr3:53076755 T/G cg18099408 chr3:52552593 STAB1 0.39 5.83 0.31 1.3e-8 Ulcerative colitis; CRC cis rs514406 0.861 rs2065477 chr1:53250213 C/T cg24675658 chr1:53192096 ZYG11B -0.56 -8.09 -0.41 1.17e-14 Monocyte count; CRC cis rs17376456 0.825 rs17314797 chr5:93234845 T/A cg21475434 chr5:93447410 FAM172A 0.78 7.82 0.4 7.47e-14 Diabetic retinopathy; CRC cis rs1348850 0.632 rs12616288 chr2:178503813 G/T cg02961200 chr2:178257176 LOC100130691;AGPS 0.62 8.66 0.43 2.19e-16 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs9814567 1.000 rs6785027 chr3:134211649 A/G cg06109529 chr3:134205091 CEP63;ANAPC13 0.8 12.29 0.56 7.8e-29 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs9488822 0.636 rs1544155 chr6:116346394 C/A cg18764771 chr6:116381957 FRK 0.26 7.44 0.38 8.76e-13 Cholesterol, total;LDL cholesterol; CRC cis rs7300001 0.538 rs7968848 chr12:110941059 T/A cg12870014 chr12:110450643 ANKRD13A 0.84 9.83 0.48 3.66e-20 Headache; CRC cis rs875971 1.000 rs11974264 chr7:65647582 C/G cg18876405 chr7:65276391 NA -0.53 -9.17 -0.45 5.48e-18 Aortic root size; CRC trans rs10504229 0.906 rs113745779 chr8:58191301 C/G cg04077850 chr5:125800366 GRAMD3 0.37 6.27 0.33 1.15e-9 Developmental language disorder (linguistic errors); CRC cis rs912057 0.601 rs1294405 chr6:6737591 A/G cg06612196 chr6:6737390 NA 0.63 10.68 0.51 4.75e-23 Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg09116932 chr22:31477245 SMTN 0.41 6.21 0.32 1.56e-9 Intelligence (multi-trait analysis); CRC cis rs79839061 0.610 rs62297062 chr4:869698 C/T cg14530993 chr4:882597 GAK 0.82 7.82 0.4 7.42e-14 Intelligence (multi-trait analysis); CRC cis rs11098499 0.629 rs28369518 chr4:120271630 T/C cg24375607 chr4:120327624 NA 0.45 7.28 0.37 2.53e-12 Corneal astigmatism; CRC cis rs6540559 1.000 rs1044516 chr1:209959614 G/T cg23283495 chr1:209979779 IRF6 0.46 7.02 0.36 1.28e-11 Cleft lip with or without cleft palate; CRC cis rs1552244 0.935 rs28815328 chr3:10062227 G/A cg13047869 chr3:10149882 C3orf24 0.51 6.97 0.36 1.72e-11 Alzheimer's disease; CRC cis rs7914558 0.966 rs10786745 chr10:104956827 A/G cg04362960 chr10:104952993 NT5C2 0.59 8.7 0.43 1.67e-16 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs5750830 0.594 rs1010169 chr22:39778167 C/T cg25956985 chr22:39795188 MAP3K7IP1 0.44 6.33 0.33 8.02e-10 Intelligence (multi-trait analysis); CRC cis rs35520189 0.591 rs12465526 chr2:113699981 A/G cg12858261 chr2:113808755 IL1F8 0.49 6.87 0.35 3.29e-11 Obstructive sleep apnea trait (apnea hypopnea index); CRC cis rs6502050 0.835 rs7406220 chr17:80077850 T/C cg19223190 chr17:80058835 NA -0.39 -6.09 -0.32 3.17e-9 Life satisfaction; CRC cis rs1008375 1.000 rs7671752 chr4:17661398 C/T cg04450456 chr4:17643702 FAM184B 0.42 6.72 0.35 8.18e-11 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs2535633 0.631 rs2581819 chr3:53016552 C/A cg15147215 chr3:52552868 STAB1 0.4 6.27 0.33 1.13e-9 Body mass index; CRC cis rs1555895 0.576 rs748112 chr10:862889 C/T cg10556349 chr10:835070 NA -0.36 -6.67 -0.35 1.07e-10 Survival in rectal cancer; CRC cis rs7727544 0.716 rs10058655 chr5:131570896 A/T cg04518342 chr5:131593106 PDLIM4 0.37 6.79 0.35 5.38e-11 Blood metabolite levels; CRC cis rs523522 0.885 rs524735 chr12:121022099 T/C cg27279351 chr12:120934652 DYNLL1 0.75 10.75 0.51 2.72e-23 High light scatter reticulocyte count; CRC cis rs7737355 0.947 rs31253 chr5:130833011 A/C cg06307176 chr5:131281290 NA 0.42 6.08 0.32 3.35e-9 Life satisfaction; CRC cis rs1448094 0.506 rs61930640 chr12:86173333 T/C cg25456477 chr12:86230367 RASSF9 0.4 6.78 0.35 5.42e-11 Major depressive disorder; CRC cis rs12586317 0.531 rs57856432 chr14:35719708 G/T cg07166546 chr14:35805898 NA -0.3 -5.84 -0.31 1.27e-8 Psoriasis; CRC cis rs4654899 0.897 rs6679753 chr1:21066634 G/C cg02927042 chr1:21476669 EIF4G3 -0.43 -6.8 -0.35 5.08e-11 Superior frontal gyrus grey matter volume; CRC cis rs929596 0.785 rs11695484 chr2:234654449 A/G cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.76 -11.19 -0.52 7.71e-25 Total bilirubin levels in HIV-1 infection; CRC cis rs13315871 0.858 rs13090428 chr3:58314412 A/G cg20936604 chr3:58311152 NA -0.75 -7.68 -0.39 1.83e-13 Cholesterol, total; CRC cis rs6665290 0.904 rs10916075 chr1:227184074 G/A cg10327440 chr1:227177885 CDC42BPA -1.04 -22.87 -0.78 5.86e-70 Myeloid white cell count; CRC cis rs853679 0.517 rs4713137 chr6:28083521 C/G cg25164649 chr6:28176230 NA 0.77 9.5 0.46 4.6e-19 Depression; CRC cis rs7224685 0.501 rs4790169 chr17:4022665 G/A cg05562828 chr17:3906858 NA -0.67 -11.74 -0.54 8.03e-27 Type 2 diabetes; CRC cis rs12325245 0.536 rs17821543 chr16:58540875 C/T cg02549819 chr16:58548995 SETD6 1.22 7.92 0.4 3.82e-14 Schizophrenia; CRC cis rs56283067 0.847 rs56300373 chr6:44690904 C/T cg18551225 chr6:44695536 NA -0.41 -5.96 -0.31 6.36e-9 Total body bone mineral density; CRC cis rs10782582 0.593 rs6673786 chr1:76149637 C/T cg10523679 chr1:76189770 ACADM -0.41 -5.78 -0.3 1.72e-8 Daytime sleep phenotypes; CRC trans rs7615952 0.866 rs13063119 chr3:125643847 G/A cg02007433 chr3:129722099 NA -0.46 -6.0 -0.31 5.27e-9 Blood pressure (smoking interaction); CRC cis rs4481887 0.888 rs12042602 chr1:248482053 C/T cg13385794 chr1:248469461 NA 0.38 6.68 0.35 1.01e-10 Common traits (Other); CRC cis rs8180040 0.620 rs2278963 chr3:47054869 G/T cg10298567 chr3:47292165 KIF9 0.41 6.3 0.33 9.73e-10 Colorectal cancer; CRC cis rs9650657 0.644 rs4395858 chr8:10521021 C/T cg27411982 chr8:10470053 RP1L1 0.36 5.65 0.3 3.56e-8 Neuroticism; CRC cis rs7208859 0.673 rs9889968 chr17:29220128 C/A cg13385521 chr17:29058706 SUZ12P 0.69 7.93 0.4 3.48e-14 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs6860806 0.507 rs273915 chr5:131660119 G/C cg04518342 chr5:131593106 PDLIM4 0.43 6.96 0.36 1.81e-11 Breast cancer; CRC cis rs2051211 1.000 rs2051211 chr3:38559749 A/G cg01465620 chr3:38496096 LOC100128640;ACVR2B -0.49 -6.5 -0.34 3.02e-10 QRS duration; CRC cis rs7615952 0.641 rs4422257 chr3:125774363 A/G cg15145296 chr3:125709740 NA -0.57 -6.75 -0.35 6.67e-11 Blood pressure (smoking interaction); CRC cis rs9783347 0.961 rs4150653 chr11:18374782 G/A cg15585147 chr11:18324498 HPS5 0.44 6.13 0.32 2.51e-9 Pancreatic cancer; CRC cis rs12971120 0.891 rs3764510 chr18:72166846 A/G cg25817165 chr18:72167213 CNDP2 -0.64 -8.68 -0.43 1.81e-16 Refractive error; CRC cis rs4664308 0.837 rs56172865 chr2:160967333 C/T cg03641300 chr2:160917029 PLA2R1 -0.71 -12.1 -0.55 3.99e-28 Idiopathic membranous nephropathy; CRC cis rs6961069 0.935 rs819435 chr7:80224372 T/G cg04458919 chr7:80252533 CD36 -0.33 -5.88 -0.31 1e-8 Platelet count; CRC cis rs28386778 0.863 rs3760254 chr17:61851751 T/G cg22520471 chr17:61851767 DDX42;CCDC47 0.74 11.55 0.54 3.91e-26 Prudent dietary pattern; CRC cis rs3772130 1.000 rs34086988 chr3:121352745 G/C cg20356878 chr3:121714668 ILDR1 0.49 7.59 0.39 3.23e-13 Cognitive performance; CRC cis rs11212617 1.000 rs641605 chr11:108101919 C/T cg12106634 chr11:108092400 ATM;NPAT 0.42 6.21 0.32 1.57e-9 Response to metformin in type 2 diabetes (glycemic); CRC cis rs758324 0.947 rs1948704 chr5:131171653 A/G cg06307176 chr5:131281290 NA 0.43 6.4 0.33 5.5e-10 Alzheimer's disease in APOE e4- carriers; CRC cis rs11792861 0.781 rs72607159 chr9:111764270 C/T cg05043794 chr9:111880884 C9orf5 -0.33 -5.75 -0.3 2.08e-8 Menarche (age at onset); CRC cis rs7666738 0.830 rs13130923 chr4:99046281 T/C cg17366294 chr4:99064904 C4orf37 0.45 7.75 0.39 1.16e-13 Colonoscopy-negative controls vs population controls; CRC trans rs2303319 0.504 rs1006428 chr2:162592559 A/C cg22627826 chr19:1240265 ATP5D -0.72 -6.24 -0.33 1.32e-9 Cognitive function; CRC cis rs1707322 0.721 rs4415615 chr1:46132109 C/T cg06784218 chr1:46089804 CCDC17 0.65 12.18 0.56 2e-28 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs9515201 0.818 rs9521733 chr13:111034542 C/T cg06243866 chr13:111019493 COL4A2 0.36 5.68 0.3 2.97e-8 White matter hyperintensity burden; CRC cis rs6952808 0.771 rs10950415 chr7:1914477 A/G cg21782813 chr7:2030301 MAD1L1 0.39 7.05 0.36 1.06e-11 Bipolar disorder and schizophrenia; CRC cis rs7173389 0.551 rs11638264 chr15:73656307 G/A cg01796676 chr15:73680284 NA 0.62 5.9 0.31 8.94e-9 Resting heart rate; CRC cis rs10504229 1.000 rs1961778 chr8:58168756 G/A cg05313129 chr8:58192883 C8orf71 -0.47 -7.26 -0.37 2.8e-12 Developmental language disorder (linguistic errors); CRC trans rs2727020 0.729 rs4315497 chr11:49214499 G/A cg03929089 chr4:120376271 NA 0.82 13.72 0.6 3.47e-34 Coronary artery disease; CRC cis rs172166 0.516 rs1225710 chr6:28100640 C/T cg25164649 chr6:28176230 NA -0.47 -6.86 -0.35 3.53e-11 Cardiac Troponin-T levels; CRC cis rs10170846 0.861 rs7571732 chr2:223538316 A/C cg25565276 chr2:223520875 FARSB -0.46 -6.18 -0.32 1.88e-9 Schizophrenia (inflammation and infection response interaction); CRC cis rs7264396 1.000 rs224418 chr20:34142527 T/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.43 -7.14 -0.37 5.93e-12 Total cholesterol levels; CRC cis rs11514810 1.000 rs9648620 chr7:1427980 T/C cg24899294 chr7:1481343 MICALL2 -0.67 -6.92 -0.36 2.43e-11 Executive inhibition (Stroop WIT and CIT) in attention deficit hyperactivity disorder; CRC cis rs7762018 0.891 rs7740218 chr6:170141552 G/A cg24289452 chr6:170231220 NA -0.54 -6.01 -0.31 5.05e-9 Thiazide-induced adverse metabolic effects in hypertensive patients; CRC cis rs17666538 0.710 rs7834337 chr8:655828 A/G cg02524346 chr8:600233 NA 0.79 7.99 0.4 2.36e-14 IgG glycosylation; CRC cis rs9583531 0.600 rs6492305 chr13:111361400 C/T cg24331049 chr13:111365604 ING1 0.57 7.92 0.4 3.6e-14 Coronary artery disease; CRC cis rs17767392 0.781 rs14030 chr14:71956141 A/C cg13720639 chr14:72061746 SIPA1L1 -0.46 -6.08 -0.32 3.38e-9 Mitral valve prolapse; CRC trans rs1005277 0.505 rs13503 chr10:38239843 C/A cg27523141 chr10:43048294 ZNF37B -0.45 -6.47 -0.34 3.49e-10 Extrinsic epigenetic age acceleration; CRC cis rs1129187 0.755 rs9471976 chr6:42920549 G/T cg03790207 chr6:42947109 PEX6 -0.52 -7.66 -0.39 2.06e-13 Alzheimer's disease in APOE e4+ carriers; CRC cis rs7618915 0.524 rs2028216 chr3:52680823 C/T cg18099408 chr3:52552593 STAB1 -0.44 -7.16 -0.37 5.27e-12 Bipolar disorder; CRC cis rs72717009 0.825 rs7529425 chr1:161479599 G/A cg10431340 chr1:161279108 MPZ -0.52 -7.02 -0.36 1.28e-11 Rheumatoid arthritis; CRC cis rs870825 0.655 rs10033035 chr4:185630880 T/C cg04058563 chr4:185651563 MLF1IP 0.72 9.1 0.45 8.81e-18 Blood protein levels; CRC cis rs9359856 0.518 rs10485242 chr6:90183389 C/T cg13799429 chr6:90582589 CASP8AP2 -0.51 -5.62 -0.3 4.04e-8 Bipolar disorder; CRC cis rs7726839 0.526 rs11960159 chr5:568685 C/T cg17948913 chr5:572064 NA 0.46 5.72 0.3 2.46e-8 Obesity-related traits; CRC cis rs7429990 0.965 rs184388 chr3:47939626 G/A cg11946769 chr3:48343235 NME6 0.46 5.9 0.31 8.99e-9 Educational attainment (years of education); CRC cis rs3091242 0.933 rs9438905 chr1:25764177 A/G cg20684491 chr1:25596433 NA 0.42 7.23 0.37 3.41e-12 Erythrocyte sedimentation rate; CRC cis rs17713451 0.593 rs79994029 chr7:151268774 A/G cg18404559 chr7:151322523 PRKAG2 -0.57 -6.41 -0.33 5.12e-10 Interleukin-4 levels; CRC cis rs3806843 0.966 rs3756338 chr5:140180561 A/G cg16607685 chr5:140181889 PCDHA2;PCDHA1;PCDHA3 -0.27 -6.22 -0.32 1.5e-9 Depressive symptoms (multi-trait analysis); CRC cis rs12760731 0.720 rs10913535 chr1:178302914 C/A cg00404053 chr1:178313656 RASAL2 0.92 9.63 0.47 1.74e-19 Obesity-related traits; CRC cis rs1387259 0.929 rs11168484 chr12:48633589 A/C cg04545296 chr12:48745243 ZNF641 0.35 6.1 0.32 2.96e-9 Obstructive sleep apnea trait (apnea hypopnea index); CRC cis rs7927771 0.826 rs2293578 chr11:47437403 C/T cg05585544 chr11:47624801 NA -0.57 -10.26 -0.49 1.31e-21 Subjective well-being; CRC cis rs3820068 0.581 rs59684759 chr1:15919893 A/G cg13390004 chr1:15929781 NA 0.5 6.93 0.36 2.16e-11 Systolic blood pressure; CRC cis rs6663390 0.510 rs1932819 chr1:208078238 C/T cg03990033 chr1:208084030 CD34 0.44 6.26 0.33 1.21e-9 Facial morphology (factor 18); CRC cis rs6570726 0.764 rs9403731 chr6:145907937 G/A cg13319975 chr6:146136371 FBXO30 -0.43 -6.27 -0.33 1.12e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs11098499 0.954 rs11098526 chr4:120390359 C/T cg24375607 chr4:120327624 NA 0.5 7.63 0.39 2.59e-13 Corneal astigmatism; CRC trans rs6951245 0.678 rs28600085 chr7:1169636 C/T cg13565492 chr6:43139072 SRF -0.73 -8.14 -0.41 8.25e-15 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC trans rs916888 0.821 rs70602 chr17:44859715 T/C cg22433210 chr17:43662623 NA -0.82 -9.07 -0.45 1.11e-17 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs4970988 0.556 rs6681426 chr1:150586971 G/A cg15448220 chr1:150897856 SETDB1 -0.48 -6.76 -0.35 6.35e-11 Urate levels; CRC cis rs6687430 0.526 rs12120962 chr1:10609505 G/A cg17425144 chr1:10567563 PEX14 0.49 9.94 0.48 1.58e-20 Hand grip strength; CRC cis rs4970988 0.556 rs2280078 chr1:150600181 C/T cg10589385 chr1:150898437 SETDB1 -0.32 -6.82 -0.35 4.43e-11 Urate levels; CRC trans rs9329221 0.521 rs17693945 chr8:10106010 C/T cg16141378 chr3:129829833 LOC729375 0.43 5.97 0.31 6.28e-9 Neuroticism; CRC trans rs12249377 0.748 rs10881834 chr10:92581244 G/A cg26894278 chr13:21016241 CRYL1 0.4 5.98 0.31 5.89e-9 White matter microstructure (global fractional anisotropy); CRC cis rs9399135 0.967 rs9402676 chr6:135355507 C/T cg22676075 chr6:135203613 NA 0.41 6.39 0.33 5.63e-10 Red blood cell count; CRC cis rs6912958 0.781 rs3934838 chr6:88284699 T/C cg08069147 chr6:88032118 GJB7;C6orf162 -0.57 -8.57 -0.43 4.19e-16 Monocyte percentage of white cells; CRC cis rs11676855 0.924 rs11680626 chr2:235927511 A/T cg14917874 chr2:235941519 SH3BP4 -0.51 -6.83 -0.35 4.16e-11 Dialysis-related mortality; CRC cis rs11758351 0.866 rs11757394 chr6:26206694 G/C cg01420254 chr6:26195488 NA 0.8 8.79 0.44 8.31e-17 Gout;Renal underexcretion gout; CRC cis rs2404602 0.669 rs12148877 chr15:76919959 T/G cg03037974 chr15:76606532 NA 0.69 12.16 0.56 2.4e-28 Blood metabolite levels; CRC cis rs7666738 0.830 rs17558151 chr4:99048699 T/C cg17366294 chr4:99064904 C4orf37 0.44 7.41 0.38 1.08e-12 Colonoscopy-negative controls vs population controls; CRC cis rs854572 0.600 rs705382 chr7:94955221 C/G cg07404485 chr7:94953653 PON1 -0.55 -9.37 -0.46 1.18e-18 Paraoxonase activity; CRC cis rs2245008 0.671 rs907036 chr16:83989850 A/T cg27171569 chr16:83987465 OSGIN1 0.56 10.91 0.52 7.29e-24 Pursuit maintenance gain; CRC trans rs9858542 0.953 rs9858280 chr3:49597737 T/C cg21659725 chr3:3221576 CRBN -0.7 -9.64 -0.47 1.56e-19 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs523522 0.962 rs10849757 chr12:120964014 G/A cg12219531 chr12:120966889 COQ5 0.69 9.28 0.46 2.36e-18 High light scatter reticulocyte count; CRC cis rs12477438 0.501 rs6751927 chr2:99740175 T/C cg14399236 chr2:99771627 LIPT1;TSGA10 0.83 14.67 0.63 7.94e-38 Chronic sinus infection; CRC cis rs1577917 0.771 rs9362232 chr6:86353622 A/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.51 -7.08 -0.36 8.81e-12 Response to antipsychotic treatment; CRC cis rs1322512 1.000 rs7765586 chr6:152949109 C/T cg03415253 chr6:152958462 SYNE1 0.42 6.41 0.33 5.06e-10 Tonometry; CRC cis rs2836974 0.644 rs2410123 chr21:40700093 C/T cg11644478 chr21:40555479 PSMG1 -0.63 -9.8 -0.48 4.73e-20 Cognitive function; CRC trans rs9581094 1.000 rs73154395 chr13:25081803 T/G ch.10.2420334F chr10:115122200 NA 0.62 6.08 0.32 3.24e-9 Sudden cardiac arrest; CRC cis rs1218582 0.774 rs4845679 chr1:154861187 G/T cg16680214 chr1:154839983 KCNN3 -0.5 -9.89 -0.48 2.36e-20 Prostate cancer; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg25934771 chr12:66696354 HELB 0.43 6.27 0.33 1.14e-9 Intelligence (multi-trait analysis); CRC cis rs440932 0.747 rs330946 chr8:9022177 A/C cg06636001 chr8:8085503 FLJ10661 0.61 8.67 0.43 2e-16 High light scatter reticulocyte percentage of red cells; CRC cis rs3733585 0.673 rs4467563 chr4:9953460 A/T cg00071950 chr4:10020882 SLC2A9 -0.55 -9.74 -0.47 7.09e-20 Cleft plate (environmental tobacco smoke interaction); CRC cis rs7769051 0.803 rs12193474 chr6:133186168 T/C cg07930552 chr6:133119739 C6orf192 0.63 7.18 0.37 4.79e-12 Type 2 diabetes nephropathy; CRC cis rs4423214 0.840 rs1792224 chr11:71176141 C/T cg13043300 chr11:71146211 DHCR7 -0.44 -5.91 -0.31 8.58e-9 Vitamin D levels; CRC cis rs9911578 1.000 rs1267545 chr17:56646909 A/G cg12560992 chr17:57184187 TRIM37 0.92 17.44 0.69 1.05e-48 Intelligence (multi-trait analysis); CRC cis rs1568889 1.000 rs34337978 chr11:28136746 A/G cg06544937 chr11:28130018 METT5D1;KIF18A 0.79 11.03 0.52 2.83e-24 Bipolar disorder; CRC cis rs9322193 0.923 rs7740278 chr6:149961252 C/T cg07701084 chr6:150067640 NUP43 0.55 8.04 0.41 1.58e-14 Lung cancer; CRC cis rs7246865 0.724 rs10424674 chr19:17183185 G/A cg19418318 chr19:17219073 MYO9B 0.44 7.0 0.36 1.45e-11 Reticulocyte fraction of red cells; CRC cis rs909002 0.800 rs4949454 chr1:32099041 A/G cg13919466 chr1:32135498 COL16A1 0.3 5.68 0.3 2.94e-8 Intelligence (multi-trait analysis); CRC cis rs501120 0.584 rs11238894 chr10:44671851 T/C cg09554077 chr10:44749378 NA 0.74 8.38 0.42 1.58e-15 Coronary artery disease;Coronary heart disease; CRC cis rs9322193 0.923 rs9800871 chr6:149965676 A/G cg13206674 chr6:150067644 NUP43 0.67 10.05 0.48 6.96e-21 Lung cancer; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg26434988 chr14:50999636 MAP4K5;ATL1 0.43 6.2 0.32 1.71e-9 Response to antipsychotic treatment; CRC cis rs727505 0.954 rs28638102 chr7:124499480 A/C cg23710748 chr7:124431027 NA -0.8 -14.18 -0.62 6.24e-36 Lewy body disease; CRC cis rs1065852 0.526 rs8138080 chr22:42396371 A/G cg22189786 chr22:42395067 WBP2NL -0.42 -5.96 -0.31 6.37e-9 Response to serotonin reuptake inhibitors in major depressive disorder (plasma drug and metabolite levels); CRC cis rs875971 1.000 rs35149210 chr7:65929925 T/C cg11764359 chr7:65958608 NA 0.62 9.91 0.48 1.96e-20 Aortic root size; CRC cis rs1799949 1.000 rs35070007 chr17:41316747 C/G cg19454999 chr17:41278357 BRCA1;NBR2 -0.41 -6.25 -0.33 1.29e-9 Menopause (age at onset); CRC cis rs1862618 0.671 rs252897 chr5:56223000 G/A cg12311346 chr5:56204834 C5orf35 -0.66 -9.94 -0.48 1.6e-20 Initial pursuit acceleration; CRC trans rs2303319 0.582 rs62187608 chr2:162431138 T/G cg18122310 chr12:50236657 BCDIN3D -0.75 -6.19 -0.32 1.77e-9 Cognitive function; CRC cis rs8016982 0.617 rs2241621 chr14:81737076 G/T cg01989461 chr14:81687754 GTF2A1 -0.49 -7.64 -0.39 2.46e-13 Schizophrenia; CRC cis rs1223397 0.702 rs13191897 chr6:13288428 G/A cg21538684 chr6:13274180 PHACTR1 0.48 5.66 0.3 3.3e-8 Blood pressure; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg24658452 chr6:133134754 RPS12 0.38 6.07 0.32 3.5e-9 Liver disease severity in Alagille syndrome; CRC cis rs9847710 1.000 rs6770152 chr3:53100214 A/C cg04503182 chr3:53078218 SFMBT1 0.4 6.17 0.32 2.04e-9 Ulcerative colitis; CRC cis rs72781680 0.898 rs72786277 chr2:24062818 T/G cg08917208 chr2:24149416 ATAD2B 0.93 9.27 0.45 2.59e-18 Lymphocyte counts; CRC cis rs6834538 1.000 rs2171280 chr4:113472637 A/G cg10021238 chr4:113569128 MIR367;LARP7 0.42 6.04 0.32 4.12e-9 Free thyroxine concentration; CRC cis rs9916302 0.706 rs6503504 chr17:37514412 A/G cg00129232 chr17:37814104 STARD3 0.58 7.09 0.36 8.09e-12 Glomerular filtration rate (creatinine); CRC cis rs7918232 0.662 rs10741125 chr10:27288925 G/A cg14442939 chr10:27389572 ANKRD26 0.65 6.98 0.36 1.59e-11 Breast cancer; CRC cis rs3741151 0.773 rs73544720 chr11:73173496 A/G cg17517138 chr11:73019481 ARHGEF17 1.04 8.44 0.42 1.01e-15 GIP levels in response to oral glucose tolerance test (120 minutes); CRC trans rs561341 0.883 rs7406056 chr17:30220224 C/T cg20587970 chr11:113659929 NA -0.95 -11.38 -0.53 1.64e-25 Hip circumference adjusted for BMI; CRC cis rs2777491 0.957 rs7181911 chr15:41674060 T/C cg18705301 chr15:41695430 NDUFAF1 -0.69 -11.18 -0.52 8.22e-25 Ulcerative colitis; CRC cis rs11098499 0.710 rs6851130 chr4:120133712 G/A cg24375607 chr4:120327624 NA -0.47 -7.77 -0.39 1.02e-13 Corneal astigmatism; CRC cis rs951366 0.789 rs823097 chr1:205681370 G/A cg07157834 chr1:205819609 PM20D1 0.77 11.28 0.53 3.66e-25 Menarche (age at onset); CRC cis rs9649213 0.593 rs1468340 chr7:97987676 T/G cg24562669 chr7:97807699 LMTK2 0.44 7.27 0.37 2.71e-12 Prostate cancer (SNP x SNP interaction); CRC cis rs7662987 0.517 rs2851277 chr4:100022910 G/T cg13256891 chr4:100009986 ADH5 0.63 8.56 0.43 4.54e-16 Smoking initiation; CRC cis rs6893807 1.000 rs13163336 chr5:87943710 C/A cg09002922 chr5:87956389 LOC645323 -0.42 -6.05 -0.32 3.83e-9 Body mass index; CRC cis rs11190604 0.945 rs11190573 chr10:102233172 T/C cg07080220 chr10:102295463 HIF1AN 0.47 5.68 0.3 2.92e-8 Palmitoleic acid (16:1n-7) levels; CRC cis rs12701220 0.522 rs12334290 chr7:1054517 A/G cg26769984 chr7:1090371 C7orf50 0.48 7.7 0.39 1.58e-13 Bronchopulmonary dysplasia; CRC cis rs10504229 0.728 rs17215753 chr8:58153764 A/G cg02290350 chr8:58132656 NA -0.51 -6.57 -0.34 1.98e-10 Developmental language disorder (linguistic errors); CRC cis rs17711722 0.727 rs2658585 chr7:65461941 A/T cg18912574 chr7:65842487 NCRNA00174 0.33 5.62 0.3 4.16e-8 Calcium levels; CRC cis rs6700896 0.931 rs4420065 chr1:66161461 T/C cg04111102 chr1:66153794 NA -0.33 -5.75 -0.3 2.01e-8 C-reactive protein;Mean corpuscular volume;Mean corpuscular hemoglobin; CRC cis rs561341 0.739 rs7213369 chr17:30211878 G/A cg12193833 chr17:30244370 NA 0.44 6.14 0.32 2.35e-9 Hip circumference adjusted for BMI; CRC cis rs1552244 0.816 rs56387520 chr3:10042782 C/T cg10729496 chr3:10149963 C3orf24 0.49 6.34 0.33 7.69e-10 Alzheimer's disease; CRC cis rs7312933 0.607 rs7965392 chr12:42540280 G/A cg11827402 chr12:42719852 PPHLN1;ZCRB1 0.65 8.93 0.44 3.03e-17 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CRC cis rs4332037 0.802 rs12113633 chr7:1932936 G/A cg02421172 chr7:1938701 MAD1L1 0.44 6.03 0.32 4.46e-9 Bipolar disorder; CRC cis rs3741151 0.686 rs11823913 chr11:73141627 C/G cg17517138 chr11:73019481 ARHGEF17 0.57 6.04 0.32 4.18e-9 GIP levels in response to oral glucose tolerance test (120 minutes); CRC cis rs2204008 0.905 rs8189449 chr12:38437377 C/A cg26384229 chr12:38710491 ALG10B 0.64 8.86 0.44 5.13e-17 Bladder cancer; CRC cis rs7731783 1 rs7731783 chr5:177060312 T/C cg03428951 chr5:177434336 FAM153C -0.4 -6.46 -0.34 3.7e-10 Methadone dose in opioid dependence; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg09741240 chr6:3000097 NQO2 0.39 6.03 0.32 4.48e-9 Liver disease severity in Alagille syndrome; CRC cis rs2880765 0.835 rs12910373 chr15:86046802 G/C cg17133734 chr15:86042851 AKAP13 0.42 6.76 0.35 6.41e-11 Coronary artery disease; CRC cis rs9322193 0.962 rs7818 chr6:150132092 A/G cg05861140 chr6:150128134 PCMT1 -0.43 -7.04 -0.36 1.12e-11 Lung cancer; CRC cis rs7847628 0.550 rs12343516 chr9:123603469 A/C cg09586646 chr9:123605570 PSMD5;LOC253039 0.79 13.75 0.6 2.71e-34 Birth weight; CRC cis rs875971 0.964 rs697969 chr7:65558478 C/A cg11764359 chr7:65958608 NA -0.6 -9.59 -0.47 2.34e-19 Aortic root size; CRC cis rs2839186 0.732 rs8131458 chr21:47694712 G/A cg12516959 chr21:47718080 NA -0.4 -6.7 -0.35 9.32e-11 Testicular germ cell tumor; CRC cis rs34172651 0.917 rs200533 chr16:24754771 C/T cg06028605 chr16:24865363 SLC5A11 -0.37 -7.08 -0.36 8.66e-12 Intelligence (multi-trait analysis); CRC cis rs344364 0.511 rs2906912 chr16:1953151 G/A cg03013636 chr16:1946785 NA 0.54 6.79 0.35 5.4e-11 Glomerular filtration rate in chronic kidney disease; CRC trans rs1814175 0.588 rs1794144 chr11:49918233 A/G cg11707556 chr5:10655725 ANKRD33B -0.52 -9.92 -0.48 1.85e-20 Height; CRC cis rs4665809 1.000 rs10048648 chr2:26320315 T/C cg22920501 chr2:26401640 FAM59B -0.5 -7.0 -0.36 1.45e-11 Gut microbiome composition (summer); CRC cis rs11785693 0.862 rs11784262 chr8:4996942 G/A cg26367366 chr8:4980734 NA 0.71 8.75 0.43 1.16e-16 Neuroticism (multi-trait analysis);Neuroticism; CRC trans rs11039798 0.588 rs12294395 chr11:48476860 C/T cg03929089 chr4:120376271 NA 0.65 6.72 0.35 8.14e-11 Axial length; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg15739944 chr9:99212660 HABP4 0.44 6.34 0.33 7.62e-10 Response to antipsychotic treatment; CRC cis rs5753618 0.583 rs7285619 chr22:31842554 C/T cg07713946 chr22:31675144 LIMK2 0.38 5.84 0.31 1.23e-8 Colorectal cancer; CRC cis rs5769765 0.773 rs11090920 chr22:50320105 A/G cg02269571 chr22:50332266 NA -0.66 -8.21 -0.41 4.94e-15 Schizophrenia; CRC cis rs28386778 0.966 rs2854206 chr17:61947203 G/A cg06601766 chr17:61851465 DDX42;CCDC47 0.44 6.02 0.32 4.62e-9 Prudent dietary pattern; CRC cis rs4727027 0.870 rs62507509 chr7:148795522 C/T cg23583168 chr7:148888333 NA -0.88 -14.62 -0.63 1.25e-37 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC cis rs7552404 0.727 rs6683437 chr1:76316619 G/A cg10523679 chr1:76189770 ACADM 0.7 8.86 0.44 5.04e-17 Blood metabolite levels;Acylcarnitine levels; CRC cis rs3857536 0.776 rs9342535 chr6:66932963 C/T cg07460842 chr6:66804631 NA -0.42 -5.7 -0.3 2.64e-8 Blood trace element (Cu levels); CRC cis rs736408 0.527 rs2336147 chr3:52626443 T/C cg10802521 chr3:52805072 NEK4 -0.49 -7.72 -0.39 1.44e-13 Bipolar disorder; CRC cis rs870825 0.929 rs72689263 chr4:185590961 C/T cg07424746 chr4:185654737 MLF1IP -0.59 -5.82 -0.31 1.4e-8 Blood protein levels; CRC cis rs7772486 0.875 rs10872583 chr6:146396699 G/T cg23711669 chr6:146136114 FBXO30 -0.65 -11.04 -0.52 2.59e-24 Lobe attachment (rater-scored or self-reported); CRC cis rs2032447 0.802 rs199755 chr6:25990367 G/A cg03517284 chr6:25882590 NA -0.55 -7.55 -0.38 4.41e-13 Intelligence (multi-trait analysis); CRC cis rs9894429 0.789 rs35887231 chr17:79587126 G/A cg21984481 chr17:79567631 NPLOC4 -0.58 -11.19 -0.53 7.42e-25 Eye color traits; CRC cis rs10504229 0.679 rs16920056 chr8:58106218 C/A cg21724239 chr8:58056113 NA 0.52 6.99 0.36 1.58e-11 Developmental language disorder (linguistic errors); CRC cis rs8180040 0.587 rs1466741 chr3:47247214 C/T cg02527881 chr3:46936655 PTH1R 0.35 6.16 0.32 2.11e-9 Colorectal cancer; CRC cis rs6835098 0.961 rs17322893 chr4:174122556 A/G cg08422745 chr4:174089978 GALNT7 0.94 14.04 0.61 2.01e-35 Dementia and core Alzheimer's disease neuropathologic changes; CRC cis rs1862618 0.853 rs6885541 chr5:56110857 G/C cg03609598 chr5:56110824 MAP3K1 -0.81 -9.7 -0.47 9.66e-20 Initial pursuit acceleration; CRC cis rs769267 0.965 rs13964 chr19:19468710 C/G cg02546618 chr19:19431379 KIAA0892;SF4 -0.48 -6.54 -0.34 2.37e-10 Tonsillectomy; CRC cis rs6951245 1.000 rs11761941 chr7:1097183 G/A cg03188948 chr7:1209495 NA 0.65 6.84 0.35 3.8e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs4664293 0.625 rs11903816 chr2:160531858 T/C cg08347373 chr2:160653686 CD302 0.39 6.52 0.34 2.67e-10 Monocyte percentage of white cells; CRC cis rs11098499 0.754 rs66900435 chr4:120249425 C/A cg09307838 chr4:120376055 NA 0.62 9.59 0.47 2.31e-19 Corneal astigmatism; CRC cis rs6546324 0.625 rs1430792 chr2:67864744 A/C cg15745817 chr2:67799979 NA -0.53 -9.25 -0.45 2.87e-18 Endometriosis; CRC cis rs713587 0.713 rs12618252 chr2:25207950 G/A cg22495460 chr2:25135724 ADCY3 0.67 11.12 0.52 1.38e-24 Body mass index in non-asthmatics; CRC cis rs2976388 0.556 rs4736323 chr8:143830359 C/T cg05569086 chr8:143859399 LYNX1 -0.38 -5.85 -0.31 1.17e-8 Urinary tract infection frequency; CRC cis rs13256369 0.950 rs12548792 chr8:8568031 T/C cg17143192 chr8:8559678 CLDN23 0.48 6.2 0.32 1.73e-9 Obesity-related traits; CRC cis rs6460942 0.630 rs17670901 chr7:12386622 G/A cg06484146 chr7:12443880 VWDE -0.64 -6.75 -0.35 6.64e-11 Coronary artery disease; CRC cis rs4731207 0.698 rs4463363 chr7:124513770 A/G cg23710748 chr7:124431027 NA -0.38 -6.08 -0.32 3.42e-9 Cutaneous malignant melanoma; CRC cis rs7605827 0.930 rs6710456 chr2:15669939 C/T cg19274914 chr2:15703543 NA -0.37 -5.66 -0.3 3.27e-8 Educational attainment (years of education); CRC cis rs2637266 0.538 rs11001787 chr10:78221963 A/T cg18941641 chr10:78392320 NA -0.36 -6.23 -0.32 1.41e-9 Pulmonary function; CRC cis rs6860806 0.507 rs2631362 chr5:131707293 A/G cg18758796 chr5:131593413 PDLIM4 -0.42 -6.79 -0.35 5.4e-11 Breast cancer; CRC cis rs6912958 0.559 rs6921504 chr6:88058972 A/G cg12350822 chr6:88032061 C6orf162;GJB7 0.44 9.07 0.45 1.14e-17 Monocyte percentage of white cells; CRC cis rs10751667 1.000 rs4074232 chr11:977682 C/G ch.11.42038R chr11:967971 AP2A2 0.68 11.57 0.54 3.22e-26 Alzheimer's disease (late onset); CRC cis rs4308124 0.708 rs2137168 chr2:111986509 C/T cg04571233 chr2:111982156 NA -0.56 -7.96 -0.4 2.81e-14 Vitiligo; CRC cis rs6598955 0.543 rs3795687 chr1:26560745 G/A cg04990556 chr1:26633338 UBXN11 0.83 10.52 0.5 1.73e-22 Obesity-related traits; CRC cis rs2836974 0.666 rs4624474 chr21:40686327 T/C cg22974920 chr21:40686053 BRWD1 -0.42 -5.69 -0.3 2.81e-8 Cognitive function; CRC cis rs7615952 0.599 rs6766327 chr3:125723677 C/G cg04553112 chr3:125709451 NA -0.52 -5.97 -0.31 6.27e-9 Blood pressure (smoking interaction); CRC cis rs7680126 0.596 rs74778870 chr4:10298583 A/G cg00071950 chr4:10020882 SLC2A9 -0.43 -5.78 -0.3 1.71e-8 Urate levels in lean individuals;Urate levels in overweight individuals;Urate levels in obese individuals; CRC cis rs7086627 0.515 rs11202963 chr10:82210392 A/G cg00277334 chr10:82204260 NA -0.84 -16.95 -0.68 9.58e-47 Post bronchodilator FEV1; CRC cis rs561341 0.941 rs8066156 chr17:30361629 A/G cg12193833 chr17:30244370 NA -0.56 -7.4 -0.38 1.15e-12 Hip circumference adjusted for BMI; CRC cis rs1129187 0.755 rs3293 chr6:42938377 G/T cg09436375 chr6:42928200 GNMT -0.35 -6.49 -0.34 3.23e-10 Alzheimer's disease in APOE e4+ carriers; CRC cis rs3768617 0.510 rs10797849 chr1:183088988 A/G ch.1.3577855R chr1:183094577 LAMC1 0.85 14.6 0.63 1.48e-37 Fuchs's corneal dystrophy; CRC cis rs2228479 0.850 rs17232630 chr16:89851179 C/T cg06558623 chr16:89946397 TCF25 1.12 10.46 0.5 2.76e-22 Skin colour saturation; CRC cis rs921968 0.541 rs58650092 chr2:219304851 C/A cg02176678 chr2:219576539 TTLL4 -0.54 -8.71 -0.43 1.5e-16 Mean corpuscular hemoglobin concentration; CRC cis rs2290159 0.800 rs3730269 chr3:12653233 G/T cg23032965 chr3:12705835 RAF1 0.47 6.31 0.33 8.78e-10 Cholesterol, total; CRC cis rs3790844 0.746 rs3790850 chr1:200005193 C/G cg13229857 chr1:200006247 NR5A2 0.54 7.61 0.39 2.83e-13 Pancreatic cancer; CRC cis rs10782582 0.593 rs4646960 chr1:76211103 C/A cg03433033 chr1:76189801 ACADM -0.46 -6.66 -0.34 1.18e-10 Daytime sleep phenotypes; CRC cis rs10504229 0.953 rs72650891 chr8:58179697 T/G cg01721255 chr8:58191610 C8orf71 0.49 6.17 0.32 2e-9 Developmental language disorder (linguistic errors); CRC cis rs12630931 1.000 rs35133414 chr3:31974182 G/C cg21375017 chr3:31988082 OSBPL10 0.43 5.97 0.31 6.2e-9 Periodontal disease-related phenotypes; CRC trans rs1814175 0.740 rs10839439 chr11:49918240 C/T cg03929089 chr4:120376271 NA -0.94 -17.85 -0.7 2.65e-50 Height; CRC cis rs11628318 0.515 rs7152144 chr14:103126101 C/T cg12046867 chr14:103022105 NA 0.42 6.13 0.32 2.54e-9 Platelet count; CRC cis rs929354 1.000 rs1182452 chr7:157053618 G/A cg16102536 chr7:156981717 UBE3C -0.37 -6.32 -0.33 8.36e-10 Body mass index; CRC cis rs12142240 0.698 rs17413694 chr1:46818416 A/C cg00530320 chr1:46809349 NSUN4 0.58 7.93 0.4 3.43e-14 Menopause (age at onset); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg21525449 chr1:156571403 GPATCH4 0.43 6.03 0.32 4.36e-9 Response to antipsychotic treatment; CRC trans rs10411161 0.702 rs10424202 chr19:52387297 G/A cg22319618 chr22:45562946 NUP50 -0.66 -7.28 -0.37 2.41e-12 Breast cancer; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg06604058 chr11:63448992 RTN3 0.42 6.43 0.33 4.45e-10 Intelligence (multi-trait analysis); CRC cis rs2811415 0.597 rs55662362 chr3:127774723 A/C cg13719885 chr3:127795394 NA -0.36 -5.62 -0.3 4.17e-8 Lung function (FEV1/FVC); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg19980912 chr5:133304180 C5orf15 0.42 6.94 0.36 2.04e-11 Liver disease severity in Alagille syndrome; CRC cis rs875971 0.862 rs10240949 chr7:65804417 A/G cg18876405 chr7:65276391 NA -0.52 -8.56 -0.43 4.45e-16 Aortic root size; CRC cis rs13118159 0.505 rs1250128 chr4:1257311 T/C cg21620606 chr4:1342894 KIAA1530 -0.38 -5.89 -0.31 9.75e-9 Longevity; CRC trans rs1814175 0.817 rs11518158 chr11:49985633 G/T cg03929089 chr4:120376271 NA -0.94 -17.92 -0.7 1.32e-50 Height; CRC cis rs1552244 1.000 rs17032278 chr3:10077955 A/G cg08888203 chr3:10149979 C3orf24 0.73 10.08 0.49 5.45e-21 Alzheimer's disease; CRC cis rs10504229 0.911 rs77203035 chr8:58175458 C/A cg22535103 chr8:58192502 C8orf71 -0.82 -12.27 -0.56 9.63e-29 Developmental language disorder (linguistic errors); CRC cis rs1707322 0.963 rs12145287 chr1:46325002 C/G cg03146154 chr1:46216737 IPP 0.57 7.93 0.4 3.45e-14 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs514406 0.708 rs546334 chr1:53326210 T/C cg25767906 chr1:53392781 SCP2 -0.54 -8.63 -0.43 2.62e-16 Monocyte count; CRC cis rs12701220 0.500 rs6463224 chr7:1140418 C/A cg04025307 chr7:1156635 C7orf50 0.48 6.01 0.31 4.85e-9 Bronchopulmonary dysplasia; CRC cis rs875971 0.862 rs1167399 chr7:65561877 G/A cg11764359 chr7:65958608 NA -0.58 -8.83 -0.44 6.38e-17 Aortic root size; CRC cis rs7666738 1.000 rs7666738 chr4:98968077 C/T cg03676636 chr4:99064102 C4orf37 0.24 6.77 0.35 6.11e-11 Colonoscopy-negative controls vs population controls; CRC cis rs1005277 0.579 rs2474595 chr10:38426782 C/G cg17219203 chr10:38645113 HSD17B7P2 0.41 5.72 0.3 2.39e-8 Extrinsic epigenetic age acceleration; CRC cis rs9463078 0.754 rs9349309 chr6:45025814 G/T cg25276700 chr6:44698697 NA -0.24 -5.79 -0.3 1.63e-8 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; CRC trans rs561341 1.000 rs56903735 chr17:30254393 T/A cg27661571 chr11:113659931 NA -0.69 -8.61 -0.43 3.11e-16 Hip circumference adjusted for BMI; CRC cis rs17376456 0.877 rs10476601 chr5:93402522 G/A cg25358565 chr5:93447407 FAM172A 1.02 10.4 0.5 4.25e-22 Diabetic retinopathy; CRC cis rs9443645 0.869 rs1567168 chr6:79536455 G/T cg11833968 chr6:79620685 NA -0.35 -6.21 -0.32 1.56e-9 Intelligence (multi-trait analysis); CRC cis rs9311474 1.000 rs6445358 chr3:52308845 C/G cg15147215 chr3:52552868 STAB1 -0.62 -10.25 -0.49 1.43e-21 Electroencephalogram traits; CRC cis rs34375054 0.525 rs7133006 chr12:125606123 G/A cg02766259 chr12:125626809 AACS -0.45 -8.51 -0.42 6.05e-16 Post bronchodilator FEV1/FVC ratio; CRC cis rs9322817 0.902 rs7773123 chr6:105173726 A/G cg02098413 chr6:105308735 HACE1 0.37 6.81 0.35 4.67e-11 Thyroid stimulating hormone; CRC cis rs2153535 0.580 rs7741456 chr6:8452424 G/A cg21535247 chr6:8435926 SLC35B3 0.5 7.45 0.38 8.15e-13 Motion sickness; CRC cis rs2304069 0.779 rs245050 chr5:149346960 C/G cg22760475 chr5:149380129 HMGXB3;TIGD6 -0.57 -6.82 -0.35 4.37e-11 HIV-1 control; CRC cis rs9660180 0.868 rs12567685 chr1:1806647 T/C cg05132306 chr1:1846340 CALML6 -0.5 -7.74 -0.39 1.22e-13 Body mass index; CRC cis rs1552244 0.882 rs68153882 chr3:10013110 T/C cg10729496 chr3:10149963 C3orf24 0.49 6.38 0.33 5.96e-10 Alzheimer's disease; CRC cis rs992157 0.835 rs2292555 chr2:219146882 G/C cg00012203 chr2:219082015 ARPC2 -0.47 -7.13 -0.37 6.31e-12 Colorectal cancer; CRC cis rs477895 0.713 rs1059440 chr11:63991801 C/T cg18225595 chr11:63971243 STIP1 -0.58 -7.7 -0.39 1.61e-13 Mean platelet volume; CRC cis rs12681287 0.640 rs7461413 chr8:87470978 C/G cg27223183 chr8:87520930 FAM82B -0.52 -7.47 -0.38 7.07e-13 Caudate activity during reward; CRC cis rs9322193 0.923 rs4354168 chr6:150017778 C/T cg13206674 chr6:150067644 NUP43 0.65 9.75 0.47 6.68e-20 Lung cancer; CRC cis rs4757319 0.532 rs6486245 chr11:15438256 G/A cg03245590 chr11:15329459 NA 0.43 7.34 0.38 1.7e-12 Breast cancer; CRC trans rs1814175 0.935 rs10839317 chr11:49657228 A/C cg11707556 chr5:10655725 ANKRD33B -0.42 -7.73 -0.39 1.35e-13 Height; CRC cis rs7044106 0.791 rs2416798 chr9:123480603 C/T cg14255062 chr9:123606675 PSMD5;LOC253039 0.46 6.72 0.35 8.06e-11 Hip circumference adjusted for BMI; CRC cis rs28386778 0.830 rs2597637 chr17:61875066 T/G cg23090583 chr17:61904693 PSMC5;FTSJ3 1.05 20.15 0.74 2.13e-59 Prudent dietary pattern; CRC cis rs4730250 0.707 rs257372 chr7:106796977 T/G cg02696742 chr7:106810147 HBP1 -0.59 -6.66 -0.34 1.14e-10 Osteoarthritis; CRC cis rs11077998 0.844 rs8064433 chr17:80501046 A/T cg10255544 chr17:80519551 FOXK2 0.38 5.94 0.31 7.06e-9 Reticulocyte fraction of red cells; CRC cis rs853679 0.517 rs9380059 chr6:28132358 A/C cg23161317 chr6:28129485 ZNF389 0.53 6.43 0.33 4.52e-10 Depression; CRC trans rs1814175 0.791 rs11040472 chr11:49703116 C/T cg11707556 chr5:10655725 ANKRD33B -0.43 -8.1 -0.41 1.1e-14 Height; CRC cis rs7493 1.000 rs12026 chr7:95041016 G/C cg07404485 chr7:94953653 PON1 -0.45 -5.92 -0.31 7.97e-9 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs11229555 0.645 rs11229443 chr11:58197188 G/C cg15696309 chr11:58395628 NA -0.82 -10.45 -0.5 2.81e-22 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; CRC cis rs1383484 0.606 rs9329364 chr15:84643242 G/A cg11189052 chr15:85197271 WDR73 -0.48 -6.03 -0.32 4.4e-9 Height; CRC cis rs1572438 0.811 rs9379179 chr6:879853 A/C cg27050936 chr6:887821 NA 0.34 5.61 0.3 4.29e-8 Aging; CRC cis rs4819052 0.851 rs1999334 chr21:46670457 A/G cg11663144 chr21:46675770 NA -0.7 -11.86 -0.55 3.01e-27 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs17818399 0.502 rs1451152 chr2:46800150 C/T cg26688816 chr2:46740690 ATP6V1E2 -0.51 -7.62 -0.39 2.8e-13 Height; CRC cis rs3106136 0.967 rs2087170 chr4:95162960 A/C cg11021082 chr4:95130006 SMARCAD1 -0.47 -7.34 -0.38 1.68e-12 Capecitabine sensitivity; CRC cis rs2949837 0.581 rs1117457 chr7:45970037 G/A cg04727332 chr7:45960243 IGFBP3 0.36 5.74 0.3 2.18e-8 Sitting height ratio; CRC cis rs7737355 0.947 rs6883034 chr5:130920415 T/C cg25547332 chr5:131281432 NA 0.4 5.65 0.3 3.41e-8 Life satisfaction; CRC trans rs2303319 0.504 rs62188960 chr2:162492578 A/C cg13490827 chr1:46269305 MAST2 -0.72 -6.21 -0.32 1.56e-9 Cognitive function; CRC cis rs4654899 0.758 rs6689852 chr1:21341051 T/C cg02927042 chr1:21476669 EIF4G3 -0.4 -6.34 -0.33 7.6e-10 Superior frontal gyrus grey matter volume; CRC cis rs9921222 0.632 rs11649268 chr16:398643 A/C cg26913058 chr16:419975 MRPL28 -0.45 -6.78 -0.35 5.65e-11 Bone mineral density (spine);Bone mineral density; CRC trans rs875971 0.660 rs2191268 chr7:66110224 C/T cg23237339 chr1:171283153 FMO4 -0.38 -6.12 -0.32 2.71e-9 Aortic root size; CRC cis rs11676348 0.729 rs13013361 chr2:218947515 A/T cg00012203 chr2:219082015 ARPC2 -0.38 -5.76 -0.3 1.96e-8 Ulcerative colitis; CRC cis rs9326248 1.000 rs10790175 chr11:117034729 A/G cg26566898 chr11:117069891 TAGLN 0.42 9.3 0.46 2.03e-18 Blood protein levels; CRC trans rs7618501 0.933 rs6809431 chr3:49804119 A/G cg21582582 chr3:182698605 DCUN1D1 0.55 8.02 0.4 1.84e-14 Intelligence (multi-trait analysis); CRC cis rs10751667 0.666 rs7394958 chr11:965944 C/G cg23136738 chr11:925521 AP2A2 -0.42 -7.09 -0.36 8.19e-12 Alzheimer's disease (late onset); CRC cis rs1046896 0.553 rs56775875 chr17:80831291 G/T cg02711726 chr17:80685570 FN3KRP -0.53 -7.15 -0.37 5.58e-12 Glycated hemoglobin levels; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg22911074 chr5:6632973 NSUN2;SRD5A1 0.39 6.68 0.35 1.04e-10 Liver disease severity in Alagille syndrome; CRC cis rs9894429 0.505 rs35570626 chr17:79611084 A/G cg09655341 chr17:79618100 PDE6G -0.36 -6.13 -0.32 2.53e-9 Eye color traits; CRC cis rs853679 0.517 rs6932109 chr6:28078303 A/G cg03623178 chr6:28175578 NA -0.94 -12.89 -0.58 4.59e-31 Depression; CRC cis rs2013441 1.000 rs2526460 chr17:20086352 G/A cg13482628 chr17:19912719 NA -0.39 -5.96 -0.31 6.54e-9 Obesity-related traits; CRC cis rs35362007 0.530 rs17835086 chr14:96012465 A/G cg13511115 chr14:96000878 GLRX5;SNHG10;SCARNA13 0.64 5.81 0.31 1.44e-8 Mean corpuscular volume;Mean corpuscular hemoglobin; CRC cis rs7618915 0.570 rs13068293 chr3:52672167 C/A cg05573699 chr3:52720067 GNL3;PBRM1 -0.47 -6.68 -0.35 1.02e-10 Bipolar disorder; CRC cis rs909002 0.925 rs10798882 chr1:32108547 C/G cg13919466 chr1:32135498 COL16A1 0.3 5.76 0.3 1.91e-8 Intelligence (multi-trait analysis); CRC cis rs6921919 0.583 rs1416918 chr6:28358335 G/C cg21251018 chr6:28226885 NKAPL 0.41 6.24 0.33 1.35e-9 Autism spectrum disorder or schizophrenia; CRC cis rs11971779 0.553 rs10269108 chr7:139106332 G/A cg07862535 chr7:139043722 LUC7L2 0.57 7.32 0.37 1.92e-12 Diisocyanate-induced asthma; CRC cis rs7737355 0.773 rs31589 chr5:131004646 G/A cg25547332 chr5:131281432 NA 0.36 5.63 0.3 3.82e-8 Life satisfaction; CRC cis rs1005277 0.579 rs2474575 chr10:38387901 C/T cg25517755 chr10:38738941 LOC399744 -0.44 -6.41 -0.33 5.05e-10 Extrinsic epigenetic age acceleration; CRC cis rs7666738 0.800 rs10028921 chr4:98962630 G/T cg17366294 chr4:99064904 C4orf37 0.43 7.3 0.37 2.16e-12 Colonoscopy-negative controls vs population controls; CRC cis rs6952808 1.000 rs10260585 chr7:1889521 G/A cg02951883 chr7:2050386 MAD1L1 -0.73 -11.53 -0.54 4.56e-26 Bipolar disorder and schizophrenia; CRC cis rs6772849 0.896 rs4857859 chr3:128348014 G/T cg08795948 chr3:128337044 NA 0.35 6.01 0.31 5e-9 Monocyte percentage of white cells;Monocyte count; CRC cis rs6724607 1.000 rs4853513 chr2:191479455 C/T cg10560079 chr2:191398806 TMEM194B -0.48 -7.05 -0.36 1.07e-11 Pulse pressure; CRC cis rs9549328 0.565 rs36145949 chr13:113616608 T/C cg08614441 chr13:113633676 MCF2L 0.4 6.97 0.36 1.69e-11 Systolic blood pressure; CRC cis rs4689388 0.926 rs4458523 chr4:6289986 G/T cg00701064 chr4:6280414 WFS1 -0.74 -12.92 -0.58 3.58e-31 Type 2 diabetes and other traits;Type 2 diabetes; CRC cis rs7772486 0.875 rs1331645 chr6:146398407 C/G cg13319975 chr6:146136371 FBXO30 -0.43 -6.61 -0.34 1.51e-10 Lobe attachment (rater-scored or self-reported); CRC cis rs12701220 0.655 rs6955290 chr7:1151066 A/G cg00990874 chr7:1149470 C7orf50 0.65 8.95 0.44 2.6e-17 Bronchopulmonary dysplasia; CRC cis rs9435341 0.930 rs12408634 chr1:107579540 G/A cg09367891 chr1:107599246 PRMT6 0.69 10.12 0.49 3.9e-21 Facial morphology (factor 21, depth of nasal alae); CRC cis rs7215564 0.818 rs4889878 chr17:78662479 G/T cg09596252 chr17:78655493 RPTOR 0.54 6.09 0.32 3.17e-9 Myopia (pathological); CRC cis rs4588572 0.537 rs7705718 chr5:77730349 T/C cg11446398 chr5:77624930 NA 0.41 5.89 0.31 9.63e-9 Triglycerides; CRC trans rs11098499 0.697 rs10020027 chr4:120381879 G/C cg25214090 chr10:38739885 LOC399744 0.66 10.56 0.5 1.18e-22 Corneal astigmatism; CRC cis rs4481887 0.927 rs4586010 chr1:248437568 G/A cg00666640 chr1:248458726 OR2T12 0.53 9.6 0.47 2.06e-19 Common traits (Other); CRC cis rs4713118 0.786 rs200502 chr6:27788062 C/T cg06470822 chr6:28175283 NA 0.79 10.17 0.49 2.72e-21 Parkinson's disease; CRC cis rs11105298 0.891 rs11105318 chr12:89926658 C/T cg08166232 chr12:89918718 WDR51B;GALNT4 -0.67 -7.87 -0.4 5.12e-14 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; CRC cis rs2832191 0.791 rs2832197 chr21:30497790 T/C cg08807101 chr21:30365312 RNF160 -0.62 -9.68 -0.47 1.16e-19 Dental caries; CRC cis rs7224685 0.501 rs781850 chr17:3957124 C/T cg21851534 chr17:3907994 ZZEF1 -0.35 -5.93 -0.31 7.85e-9 Type 2 diabetes; CRC cis rs11190604 1.000 rs1106565 chr10:102211613 T/C cg07570687 chr10:102243282 WNT8B 0.44 5.64 0.3 3.61e-8 Palmitoleic acid (16:1n-7) levels; CRC cis rs2797160 1.000 rs1739378 chr6:126012262 C/A cg05901451 chr6:126070800 HEY2 0.39 6.09 0.32 3.17e-9 Endometrial cancer; CRC cis rs3857067 1.000 rs899134 chr4:95019675 C/G cg11021082 chr4:95130006 SMARCAD1 -0.4 -6.05 -0.32 3.9e-9 QT interval; CRC cis rs62064224 0.902 rs35830939 chr17:30627564 A/C cg12855166 chr17:30846586 MYO1D -0.37 -5.88 -0.31 9.92e-9 Schizophrenia; CRC cis rs9462027 0.628 rs2814992 chr6:34617144 A/G cg07306190 chr6:34760872 UHRF1BP1 -0.35 -6.29 -0.33 1e-9 Systemic lupus erythematosus; CRC cis rs12580194 0.593 rs60774348 chr12:55757717 A/G cg19537932 chr12:55886519 OR6C68 -0.72 -9.07 -0.45 1.12e-17 Cancer; CRC cis rs853679 0.517 rs9380061 chr6:28132803 T/C cg12963246 chr6:28129442 ZNF389 0.49 5.7 0.3 2.71e-8 Depression; CRC cis rs8060686 0.623 rs6499163 chr16:68243486 G/T cg26727032 chr16:67993705 SLC12A4 -0.62 -9.55 -0.47 3.11e-19 HDL cholesterol;Metabolic syndrome; CRC cis rs12325245 0.536 rs35908812 chr16:58587426 T/C cg26666090 chr16:58549219 SETD6 0.92 6.25 0.33 1.26e-9 Schizophrenia; CRC cis rs2228479 0.867 rs11645970 chr16:89958118 G/A cg19635926 chr16:89946313 TCF25 0.69 6.92 0.36 2.41e-11 Skin colour saturation; CRC cis rs9463078 0.845 rs1023090 chr6:45012381 T/C cg25276700 chr6:44698697 NA -0.28 -6.73 -0.35 7.76e-11 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; CRC cis rs2841277 0.802 rs2841269 chr14:105386149 C/G cg15352829 chr14:105391018 PLD4 -0.48 -10.06 -0.48 6.45e-21 Rheumatoid arthritis; CRC cis rs1552244 1.000 rs113771705 chr3:10075983 T/C cg02579736 chr3:10068473 FANCD2;CIDECP 1.05 14.06 0.61 1.71e-35 Alzheimer's disease; CRC cis rs2243480 1.000 rs1723270 chr7:65469830 T/G cg12463550 chr7:65579703 CRCP 0.67 6.4 0.33 5.29e-10 Diabetic kidney disease; CRC cis rs4474465 0.790 rs6592790 chr11:78262618 T/C cg27205649 chr11:78285834 NARS2 0.49 6.39 0.33 5.8e-10 Alzheimer's disease (survival time); CRC cis rs6570726 0.846 rs426874 chr6:145880630 A/C cg13319975 chr6:146136371 FBXO30 -0.4 -5.95 -0.31 6.85e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs13108904 0.967 rs4428235 chr4:1278891 C/T cg05665937 chr4:1216051 CTBP1 0.4 5.88 0.31 9.81e-9 Obesity-related traits; CRC cis rs1005277 0.579 rs2749616 chr10:38510993 A/T cg17219203 chr10:38645113 HSD17B7P2 -0.41 -5.69 -0.3 2.75e-8 Extrinsic epigenetic age acceleration; CRC cis rs3824347 0.839 rs10781258 chr9:77618438 C/A cg01251476 chr9:77566080 C9orf40 0.36 5.67 0.3 3.21e-8 Urinary magnesium-to-creatinine ratio; CRC cis rs6860806 0.661 rs2136188 chr5:131577514 A/G cg22638593 chr5:131593259 PDLIM4 -0.41 -7.7 -0.39 1.66e-13 Breast cancer; CRC cis rs7572733 0.592 rs17731449 chr2:198465840 T/C cg10820045 chr2:198174542 NA 0.35 6.29 0.33 1.01e-9 Dermatomyositis; CRC cis rs7085104 0.572 rs284858 chr10:104573936 T/C cg04362960 chr10:104952993 NT5C2 -0.54 -7.91 -0.4 3.95e-14 Immature fraction of reticulocytes;Schizophrenia; CRC cis rs208515 0.525 rs12193034 chr6:66677866 C/T cg07460842 chr6:66804631 NA 0.94 11.85 0.55 3.1e-27 Exhaled nitric oxide levels; CRC trans rs11098499 1.000 rs11726229 chr4:120211580 C/T cg25214090 chr10:38739885 LOC399744 0.52 7.86 0.4 5.44e-14 Corneal astigmatism; CRC cis rs4718428 0.672 rs4718412 chr7:66286867 C/T cg12165864 chr7:66369176 NA 0.41 5.75 0.3 2.03e-8 Corneal structure; CRC cis rs4478858 0.602 rs7515867 chr1:31724744 C/T cg00250761 chr1:31883323 NA 0.32 5.95 0.31 6.84e-9 Alcohol dependence; CRC cis rs2067615 0.579 rs10778509 chr12:107162918 G/A cg13491945 chr12:107078410 RFX4 0.34 5.84 0.31 1.26e-8 Heart rate; CRC trans rs11148252 0.508 rs1886542 chr13:52706281 A/C cg18335740 chr13:41363409 SLC25A15 0.53 7.89 0.4 4.58e-14 Lewy body disease; CRC cis rs62408225 1.000 rs905670 chr6:90958502 G/A cg06866423 chr6:90926672 BACH2 0.49 8.06 0.41 1.42e-14 Eosinophil counts;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC cis rs4076764 1.000 rs6683181 chr1:163417077 C/T cg24596788 chr1:163392923 NA -0.66 -10.65 -0.51 6.15e-23 Motion sickness; CRC cis rs1552244 1.000 rs67852463 chr3:10157205 G/C cg10729496 chr3:10149963 C3orf24 0.56 7.26 0.37 2.89e-12 Alzheimer's disease; CRC cis rs2652834 1.000 rs36116701 chr15:63397494 T/C cg05507819 chr15:63340323 TPM1 0.46 6.05 0.32 3.88e-9 HDL cholesterol; CRC cis rs11971779 0.680 rs111461944 chr7:139077903 G/C cg07862535 chr7:139043722 LUC7L2 0.57 7.35 0.38 1.61e-12 Diisocyanate-induced asthma; CRC cis rs6582630 0.638 rs12231073 chr12:38526901 T/G cg13010199 chr12:38710504 ALG10B -0.44 -6.33 -0.33 8.13e-10 Drug-induced liver injury (flucloxacillin); CRC cis rs4713118 0.824 rs2179095 chr6:27750858 A/G cg06470822 chr6:28175283 NA -0.74 -9.99 -0.48 1.07e-20 Parkinson's disease; CRC cis rs7677751 0.806 rs7673027 chr4:55096180 T/A cg13615338 chr4:55094005 PDGFRA 0.4 5.81 0.3 1.5e-8 Corneal astigmatism; CRC cis rs2658782 0.789 rs56091149 chr11:93073640 A/C cg15737290 chr11:93063684 CCDC67 -0.64 -8.93 -0.44 3.18e-17 Pulmonary function decline; CRC cis rs7811142 0.830 rs78256546 chr7:99952970 A/G cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.94 12.7 0.57 2.49e-30 Platelet count; CRC cis rs6741819 0.740 rs700943 chr2:7126569 G/A cg27144453 chr2:7172511 RNF144A -0.41 -5.88 -0.31 9.83e-9 Response to antipsychotic treatment; CRC cis rs1129187 0.755 rs9462856 chr6:42926024 T/C cg03790207 chr6:42947109 PEX6 -0.49 -6.91 -0.36 2.51e-11 Alzheimer's disease in APOE e4+ carriers; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg03437924 chr16:25123326 LCMT1 0.47 7.62 0.39 2.67e-13 Liver disease severity in Alagille syndrome; CRC cis rs28386778 0.897 rs9906247 chr17:61857314 T/C cg06873352 chr17:61820015 STRADA 0.8 15.25 0.64 4.41e-40 Prudent dietary pattern; CRC cis rs4409675 0.576 rs2295367 chr1:28224312 C/T cg23691781 chr1:28212827 C1orf38 0.32 7.34 0.37 1.73e-12 Corneal astigmatism; CRC cis rs6951245 0.935 rs79067319 chr7:1065548 C/T cg03188948 chr7:1209495 NA 0.62 6.47 0.34 3.63e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs951366 0.617 rs9438393 chr1:205782718 A/G cg06877462 chr1:205807181 PM20D1 0.38 5.91 0.31 8.48e-9 Menarche (age at onset); CRC cis rs7208859 0.623 rs11658022 chr17:29085359 A/T cg13385521 chr17:29058706 SUZ12P 0.74 8.34 0.42 2.11e-15 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg08817171 chr15:69706672 KIF23 0.52 7.77 0.39 1.03e-13 Intelligence (multi-trait analysis); CRC cis rs6502050 0.835 rs8077772 chr17:80117220 A/G cg19223190 chr17:80058835 NA -0.38 -6.04 -0.32 4.07e-9 Life satisfaction; CRC cis rs2576037 0.583 rs2187091 chr18:44520048 T/C cg07643061 chr18:44555308 TCEB3C;TCEB3CL;KATNAL2 -0.35 -5.91 -0.31 8.79e-9 Personality dimensions; CRC cis rs28386778 0.897 rs2584615 chr17:61927774 T/C cg23090583 chr17:61904693 PSMC5;FTSJ3 1.03 19.93 0.74 1.63e-58 Prudent dietary pattern; CRC cis rs11599315 0.507 rs12218307 chr10:1341914 G/A cg09624528 chr10:1369823 ADARB2 0.39 5.87 0.31 1.04e-8 Thiazide-induced adverse metabolic effects in hypertensive patients; CRC cis rs10256972 0.758 rs2280724 chr7:1064720 A/G cg22907277 chr7:1156413 C7orf50 0.46 6.66 0.34 1.14e-10 Longevity;Endometriosis; CRC cis rs853679 0.760 rs9468317 chr6:28198456 A/G cg06470822 chr6:28175283 NA 0.75 8.32 0.42 2.38e-15 Depression; CRC cis rs7605827 0.930 rs2052439 chr2:15702029 C/G cg19274914 chr2:15703543 NA 0.39 5.8 0.3 1.57e-8 Educational attainment (years of education); CRC cis rs6502050 0.799 rs12940433 chr17:80120826 C/T cg22110888 chr17:80059540 CCDC57 0.4 6.38 0.33 5.96e-10 Life satisfaction; CRC cis rs4654899 0.758 rs7521711 chr1:21400218 A/G cg02927042 chr1:21476669 EIF4G3 -0.39 -6.16 -0.32 2.09e-9 Superior frontal gyrus grey matter volume; CRC cis rs2898681 0.642 rs11538878 chr4:53728524 T/C cg00338735 chr4:53728038 RASL11B 0.41 6.49 0.34 3.2e-10 Optic nerve measurement (cup area); CRC cis rs951366 1.000 rs951366 chr1:205685352 C/T cg14159672 chr1:205819179 PM20D1 0.42 5.89 0.31 9.71e-9 Menarche (age at onset); CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg00012762 chr17:72744649 SLC9A3R1 -0.42 -6.34 -0.33 7.76e-10 Myopia (pathological); CRC cis rs2180341 0.920 rs9401951 chr6:127671632 A/C cg24812749 chr6:127587940 RNF146 0.95 13.32 0.59 1.16e-32 Breast cancer; CRC cis rs364477 0.818 rs279886 chr9:979585 G/T cg13952963 chr9:998547 NA 0.5 6.25 0.33 1.29e-9 Major depressive disorder; CRC cis rs950169 0.579 rs12913054 chr15:84664456 A/G cg24253500 chr15:84953950 NA 0.4 6.3 0.33 9.53e-10 Schizophrenia; CRC cis rs6674176 1.000 rs6674176 chr1:44379957 G/A cg12908607 chr1:44402522 ARTN -0.54 -9.35 -0.46 1.44e-18 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Cognitive ability; CRC cis rs10256972 0.567 rs2949185 chr7:1209013 A/G cg03188948 chr7:1209495 NA 0.57 8.37 0.42 1.69e-15 Longevity;Endometriosis; CRC cis rs7605827 0.930 rs4133515 chr2:15696655 A/G cg19274914 chr2:15703543 NA 0.39 5.8 0.3 1.57e-8 Educational attainment (years of education); CRC cis rs10751667 0.643 rs12278229 chr11:946985 A/G ch.11.42038R chr11:967971 AP2A2 0.59 10.02 0.48 8.39e-21 Alzheimer's disease (late onset); CRC cis rs7408868 1.000 rs7254735 chr19:15263385 A/G cg14696996 chr19:15285081 NOTCH3 0.75 7.5 0.38 5.89e-13 Pulse pressure; CRC cis rs6089584 0.507 rs28545731 chr20:60634102 C/T cg23262073 chr20:60523788 NA -0.37 -5.7 -0.3 2.65e-8 Body mass index; CRC cis rs7113874 0.589 rs6578968 chr11:8480719 G/T cg17679104 chr11:8615758 STK33 -0.34 -5.67 -0.3 3.1e-8 Body mass index in physically active individuals;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs2153535 0.601 rs4140584 chr6:8540614 C/G cg21535247 chr6:8435926 SLC35B3 -0.5 -7.54 -0.38 4.66e-13 Motion sickness; CRC cis rs7493 1.000 rs2040993 chr7:95047300 T/A cg07404485 chr7:94953653 PON1 -0.45 -5.94 -0.31 7.43e-9 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs12824058 0.799 rs4759656 chr12:130815804 G/A cg24838063 chr12:130822603 PIWIL1 0.59 9.98 0.48 1.13e-20 Menopause (age at onset); CRC trans rs916888 0.773 rs199534 chr17:44824213 T/G cg23590916 chr17:43697445 MGC57346 0.69 6.65 0.34 1.2e-10 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs2180341 0.920 rs1073932 chr6:127682009 G/T cg27446573 chr6:127587934 RNF146 0.92 13.23 0.59 2.47e-32 Breast cancer; CRC cis rs9462027 0.539 rs9469883 chr6:34758627 G/A cg07306190 chr6:34760872 UHRF1BP1 -0.34 -6.1 -0.32 3.05e-9 Systemic lupus erythematosus; CRC cis rs4713118 0.629 rs203887 chr6:28021269 C/T cg02683197 chr6:28174875 NA 0.66 7.99 0.4 2.37e-14 Parkinson's disease; CRC cis rs7131987 0.683 rs12366505 chr12:29474110 C/T cg09582351 chr12:29534625 ERGIC2 -0.34 -7.19 -0.37 4.36e-12 QT interval; CRC cis rs763014 0.966 rs4984677 chr16:671682 A/G cg04562611 chr16:615315 C16orf11 0.38 6.47 0.34 3.56e-10 Height; CRC cis rs911555 0.655 rs10149470 chr14:104017953 A/G cg12935359 chr14:103987150 CKB -0.53 -9.18 -0.45 4.97e-18 Intelligence (multi-trait analysis); CRC cis rs1023500 0.505 rs134874 chr22:42661144 A/G cg04733989 chr22:42467013 NAGA 0.47 6.92 0.36 2.33e-11 Schizophrenia; CRC cis rs10504229 0.683 rs73603874 chr8:58108340 G/A cg22535103 chr8:58192502 C8orf71 -0.68 -8.76 -0.43 1.08e-16 Developmental language disorder (linguistic errors); CRC cis rs17490626 0.568 rs12413525 chr10:71211721 C/A cg12610070 chr10:71211762 TSPAN15 -0.42 -7.63 -0.39 2.6e-13 Thrombosis; CRC cis rs1580019 0.844 rs1376290 chr7:32486922 C/T cg07520158 chr7:32535189 LSM5;AVL9 0.49 6.49 0.34 3.18e-10 Cognitive ability; CRC cis rs7312933 0.533 rs11181499 chr12:42818761 A/G cg19980929 chr12:42632907 YAF2 0.41 6.27 0.33 1.11e-9 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CRC cis rs35110281 0.837 rs2838341 chr21:45076443 A/G cg01579765 chr21:45077557 HSF2BP -0.38 -7.29 -0.37 2.26e-12 Mean corpuscular volume; CRC cis rs7208859 0.623 rs80355557 chr17:29154421 C/T cg01831904 chr17:28903510 LRRC37B2 -0.62 -6.5 -0.34 2.9e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs7618915 0.547 rs11177 chr3:52721305 G/A cg11645453 chr3:52864694 ITIH4 0.37 6.4 0.33 5.48e-10 Bipolar disorder; CRC cis rs780096 0.546 rs1060525 chr2:27635582 A/G cg02592271 chr2:27665507 KRTCAP3 -0.25 -5.74 -0.3 2.2e-8 Total body bone mineral density; CRC cis rs7089973 0.836 rs1966384 chr10:116627910 G/T cg03647239 chr10:116582469 FAM160B1 0.41 5.66 0.3 3.36e-8 Bipolar disorder or attention deficit hyperactivity disorder; CRC cis rs611744 0.647 rs587340 chr8:109246032 C/A cg18478394 chr8:109455254 TTC35 0.38 5.83 0.31 1.31e-8 Dupuytren's disease; CRC cis rs3768617 0.706 rs11588675 chr1:182988052 C/T ch.1.3577855R chr1:183094577 LAMC1 0.64 9.69 0.47 1.09e-19 Fuchs's corneal dystrophy; CRC cis rs7618915 0.501 rs2159644 chr3:52774530 C/T cg15147215 chr3:52552868 STAB1 -0.63 -10.74 -0.51 2.95e-23 Bipolar disorder; CRC cis rs4713118 0.955 rs9468203 chr6:27688667 A/G cg03623178 chr6:28175578 NA 0.6 7.82 0.4 7.2e-14 Parkinson's disease; CRC cis rs11628318 0.614 rs7154538 chr14:103068112 A/G cg23461800 chr14:103021989 NA -0.64 -7.41 -0.38 1.07e-12 Platelet count; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg20779414 chr12:57505882 STAT6 0.43 6.05 0.32 4.05e-9 Response to antipsychotic treatment; CRC cis rs908922 0.676 rs525960 chr1:152497866 T/A cg23254163 chr1:152506842 NA 0.5 10.11 0.49 4.05e-21 Hair morphology; CRC cis rs12893668 0.638 rs11851616 chr14:104065600 G/A cg08213375 chr14:104286397 PPP1R13B 0.4 6.34 0.33 7.5e-10 Reticulocyte count; CRC cis rs1799949 1.000 rs8176212 chr17:41226601 G/C cg01879757 chr17:41196368 BRCA1 -0.42 -6.29 -0.33 1.02e-9 Menopause (age at onset); CRC cis rs9488822 0.636 rs1544155 chr6:116346394 C/A cg15226275 chr6:116381976 FRK 0.3 8.47 0.42 8.36e-16 Cholesterol, total;LDL cholesterol; CRC trans rs1933755 0.541 rs11154595 chr6:130916665 C/T cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 0.88 6.55 0.34 2.16e-10 Colorectal cancer (calcium intake interaction); CRC cis rs1448094 0.617 rs1502799 chr12:86474921 T/C cg02569458 chr12:86230093 RASSF9 -0.42 -7.12 -0.37 6.98e-12 Major depressive disorder; CRC cis rs7917772 0.636 rs2249850 chr10:104512006 A/G cg22532475 chr10:104410764 TRIM8 -0.39 -6.25 -0.33 1.3e-9 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC cis rs9420 0.961 rs12805841 chr11:57443842 G/A cg23127183 chr11:57508653 C11orf31 -0.52 -7.04 -0.36 1.12e-11 Schizophrenia; CRC cis rs6502050 0.634 rs11077973 chr17:80095191 C/T cg25804541 chr17:80189381 SLC16A3 -0.31 -5.97 -0.31 6.08e-9 Life satisfaction; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg15539395 chr19:59086703 MGC2752 0.47 6.63 0.34 1.38e-10 Response to antipsychotic treatment; CRC cis rs9911578 1.000 rs11079365 chr17:56945430 T/C cg12560992 chr17:57184187 TRIM37 0.92 17.0 0.68 6.03e-47 Intelligence (multi-trait analysis); CRC cis rs11252926 0.565 rs60553947 chr10:474284 T/C cg03684893 chr10:554711 DIP2C 0.34 5.67 0.3 3.16e-8 Psychosis in Alzheimer's disease; CRC cis rs4638749 0.953 rs12475415 chr2:108860477 G/A cg25838818 chr2:108905173 SULT1C2 -0.37 -5.98 -0.31 5.88e-9 Blood pressure; CRC trans rs3851050 0.757 rs12778754 chr10:81869642 G/A cg04055819 chr10:13749602 FRMD4A 0.44 6.04 0.32 4.22e-9 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs4319547 0.661 rs10846830 chr12:122897220 C/G cg05707623 chr12:122985044 ZCCHC8 -0.74 -9.21 -0.45 3.91e-18 Body mass index; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg25522312 chr4:120988417 MAD2L1 0.46 6.8 0.35 4.88e-11 Intelligence (multi-trait analysis); CRC trans rs2189609 0.521 rs2526066 chr16:74037837 A/C cg20047235 chr7:150755417 CDK5;SLC4A2 -0.46 -6.22 -0.32 1.52e-9 Energy expenditure (24h); CRC cis rs17270561 0.609 rs1165156 chr6:25792978 T/C cg16482183 chr6:26056742 HIST1H1C 0.6 8.12 0.41 9.28e-15 Iron status biomarkers; CRC cis rs4713118 0.513 rs149941 chr6:28001033 T/C cg25164649 chr6:28176230 NA 0.62 8.95 0.44 2.58e-17 Parkinson's disease; CRC cis rs55823223 0.648 rs936394 chr17:73852008 C/A cg14829360 chr17:73884958 NA -0.46 -6.95 -0.36 2.03e-11 Psoriasis; CRC cis rs1555895 0.576 rs4229 chr10:856918 A/T cg10556349 chr10:835070 NA -0.38 -7.52 -0.38 5.43e-13 Survival in rectal cancer; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg07923305 chr1:46598507 PIK3R3 0.56 7.59 0.39 3.23e-13 Thyroid stimulating hormone; CRC cis rs9948 0.655 rs62156210 chr2:97393736 A/T cg20312557 chr2:97357134 FER1L5 -0.6 -5.61 -0.3 4.38e-8 Erectile dysfunction and prostate cancer treatment; CRC cis rs755249 0.567 rs2036464 chr1:39688242 A/G cg18385671 chr1:39797026 MACF1 -0.43 -6.13 -0.32 2.48e-9 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs7584330 0.737 rs7568588 chr2:238364342 G/T cg11271282 chr2:238384023 NA 0.43 5.88 0.31 9.83e-9 Prostate cancer; CRC cis rs6912958 0.559 rs451829 chr6:88041919 A/G cg04972856 chr6:88032051 C6orf162;GJB7 0.33 6.3 0.33 9.59e-10 Monocyte percentage of white cells; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg21144587 chr2:27851409 GPN1;CCDC121 0.44 7.05 0.36 1.08e-11 Intelligence (multi-trait analysis); CRC cis rs7591163 1.000 rs2056566 chr2:228713241 G/A cg21577049 chr2:228736449 WDR69 -0.47 -6.22 -0.32 1.5e-9 Blood pressure; CRC cis rs6502050 0.814 rs9894554 chr17:80073423 C/G cg25804541 chr17:80189381 SLC16A3 0.33 6.29 0.33 1.02e-9 Life satisfaction; CRC cis rs2303745 0.589 rs6512182 chr19:17399476 G/T cg02221750 chr19:17393354 ANKLE1 -0.46 -6.8 -0.35 5.03e-11 Systemic lupus erythematosus; CRC cis rs896854 0.812 rs2340586 chr8:95969261 G/A cg23172400 chr8:95962367 TP53INP1 -0.48 -8.14 -0.41 8.48e-15 Type 2 diabetes; CRC cis rs3733585 0.683 rs6449140 chr4:9936437 G/C cg00071950 chr4:10020882 SLC2A9 -0.64 -11.38 -0.53 1.54e-25 Cleft plate (environmental tobacco smoke interaction); CRC cis rs7264396 1.000 rs224434 chr20:34153856 A/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.43 -7.04 -0.36 1.15e-11 Total cholesterol levels; CRC cis rs9826463 0.582 rs73238140 chr3:142046665 T/G cg20824294 chr3:142316082 PLS1 0.35 5.72 0.3 2.41e-8 QRS duration in Tripanosoma cruzi seropositivity; CRC cis rs2456568 0.771 rs2102333 chr11:93634749 G/A cg26875233 chr11:93583750 C11orf90 -0.32 -6.27 -0.33 1.11e-9 Response to serotonin reuptake inhibitors in major depressive disorder; CRC cis rs9402673 0.517 rs978036 chr6:135342903 C/T cg22676075 chr6:135203613 NA 0.4 6.25 0.33 1.27e-9 Reticulocyte count;High light scatter reticulocyte count; CRC cis rs10540 1.000 rs61876336 chr11:489537 C/T cg03352830 chr11:487213 PTDSS2 0.65 7.33 0.37 1.83e-12 Body mass index; CRC cis rs34172651 0.517 rs189919 chr16:24737741 G/A cg06505273 chr16:24850292 NA -0.48 -5.81 -0.31 1.48e-8 Intelligence (multi-trait analysis); CRC cis rs1950626 0.827 rs35829821 chr14:101409763 A/G cg02351406 chr14:101447389 SNORD114-20;SNORD114-21 0.95 15.98 0.66 6.18e-43 Pelvic organ prolapse (moderate/severe); CRC cis rs7113874 0.524 rs4612809 chr11:8620038 T/C cg02811074 chr11:8615871 STK33 0.33 5.88 0.31 9.85e-9 Body mass index in physically active individuals;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs3018066 0.666 rs75318236 chr4:106960346 T/A cg01869342 chr4:106983673 TBCK 0.5 6.44 0.33 4.28e-10 Cancer; CRC cis rs282587 0.569 rs432522 chr13:113400015 A/G cg04656015 chr13:113407548 ATP11A 0.62 7.97 0.4 2.63e-14 Glycated hemoglobin levels; CRC cis rs2732480 0.538 rs1387260 chr12:48703091 A/C cg21466736 chr12:48725269 NA -0.58 -8.59 -0.43 3.46e-16 Hemoglobin concentration;Red blood cell count;Hematocrit; CRC cis rs35883536 1.000 rs2282253 chr1:101094383 C/G cg14515779 chr1:101123966 NA -0.43 -8.39 -0.42 1.49e-15 Monocyte count; CRC cis rs4713118 0.866 rs9468217 chr6:27726467 G/A cg20933634 chr6:27740509 NA 0.53 6.54 0.34 2.38e-10 Parkinson's disease; CRC trans rs916888 0.773 rs9896243 chr17:44826056 C/G cg07870213 chr5:140052090 DND1 0.91 10.01 0.48 9.31e-21 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs35146811 0.735 rs6465766 chr7:99785671 A/G cg00553149 chr7:99775558 STAG3;GPC2 0.25 5.97 0.31 6.07e-9 Coronary artery disease; CRC cis rs6968419 0.650 rs1881287 chr7:115866354 A/G cg02561103 chr7:115862891 TES -0.43 -6.45 -0.33 4.1e-10 Intraocular pressure; CRC cis rs10504229 0.683 rs11784908 chr8:58131472 T/C cg05313129 chr8:58192883 C8orf71 -0.43 -6.11 -0.32 2.74e-9 Developmental language disorder (linguistic errors); CRC cis rs11098699 0.821 rs2083935 chr4:124214338 A/C cg09941581 chr4:124220074 SPATA5 0.42 6.28 0.33 1.05e-9 Mosquito bite size; CRC cis rs6951245 1.000 rs11768761 chr7:1069807 A/G cg18402987 chr7:1209562 NA 0.64 6.77 0.35 6.03e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs9911578 0.835 rs9889419 chr17:56473259 C/T cg12560992 chr17:57184187 TRIM37 0.84 14.44 0.62 5.8e-37 Intelligence (multi-trait analysis); CRC cis rs9443645 0.527 rs9350792 chr6:79587173 A/G cg05283184 chr6:79620031 NA -0.45 -6.59 -0.34 1.72e-10 Intelligence (multi-trait analysis); CRC cis rs875971 1.000 rs12698523 chr7:65968113 C/G cg12463550 chr7:65579703 CRCP 0.47 6.79 0.35 5.17e-11 Aortic root size; CRC trans rs11088226 0.681 rs2833906 chr21:33945521 G/T cg09050820 chr6:167586206 TCP10L2 0.85 9.13 0.45 7.32e-18 Gastritis; CRC cis rs2249694 1.000 rs8192781 chr10:135354251 T/G cg20169779 chr10:135381914 SYCE1 0.54 8.63 0.43 2.68e-16 Obesity-related traits; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg25759457 chr1:172502420 C1orf9 0.46 5.98 0.31 5.81e-9 Thyroid stimulating hormone; CRC cis rs877282 0.583 rs11253425 chr10:815173 G/A cg17470449 chr10:769945 NA 0.57 8.02 0.4 1.89e-14 Uric acid levels; CRC cis rs2439831 0.850 rs28524541 chr15:44124831 A/G cg02155558 chr15:43621948 ADAL;LCMT2 0.67 7.41 0.38 1.08e-12 Lung cancer in ever smokers; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg14729455 chr14:53019147 TXNDC16;GPR137C 0.47 6.71 0.35 8.52e-11 Response to antipsychotic treatment; CRC cis rs2979489 0.891 rs17551512 chr8:30330109 A/G cg26383811 chr8:30366931 RBPMS -0.7 -9.77 -0.47 5.95e-20 Mean corpuscular hemoglobin;Plateletcrit;Neutrophil count;Granulocyte count;Sum basophil neutrophil counts;Mean corpuscular volume;Myeloid white cell count;Sum neutrophil eosinophil counts; CRC cis rs8044995 0.563 rs56220628 chr16:68384837 G/A cg05110241 chr16:68378359 PRMT7 -0.7 -7.62 -0.39 2.82e-13 Schizophrenia; CRC cis rs4654899 1.000 rs6702110 chr1:21515906 A/G cg02927042 chr1:21476669 EIF4G3 -0.44 -6.98 -0.36 1.6e-11 Superior frontal gyrus grey matter volume; CRC trans rs6550704 0.687 rs9865314 chr3:22634337 A/G cg00894870 chr1:19578612 MRTO4;KIAA0090 -0.41 -6.04 -0.32 4.18e-9 Daytime sleep phenotypes; CRC cis rs7771547 0.573 rs664370 chr6:36393816 A/G cg07856975 chr6:36356162 ETV7 0.41 5.99 0.31 5.39e-9 Platelet distribution width; CRC trans rs2832077 1.000 rs9983229 chr21:30137674 A/G cg14791747 chr16:20752902 THUMPD1 -0.53 -6.52 -0.34 2.68e-10 Cognitive test performance; CRC cis rs4713118 0.869 rs7773070 chr6:27728827 T/C cg08798685 chr6:27730294 NA -0.42 -6.04 -0.32 4.07e-9 Parkinson's disease; CRC cis rs7666738 0.830 rs7680909 chr4:98934604 A/G cg17366294 chr4:99064904 C4orf37 0.43 7.32 0.37 1.95e-12 Colonoscopy-negative controls vs population controls; CRC cis rs9291683 0.546 rs10939672 chr4:10052136 A/G cg00071950 chr4:10020882 SLC2A9 0.64 11.56 0.54 3.74e-26 Bone mineral density; CRC cis rs9303401 0.659 rs61291849 chr17:56909867 T/C cg10487724 chr17:56770010 TEX14;RAD51C 0.76 9.58 0.47 2.51e-19 Cognitive test performance; CRC cis rs2811415 0.597 rs9834124 chr3:127741260 C/G cg13719885 chr3:127795394 NA -0.39 -5.99 -0.31 5.56e-9 Lung function (FEV1/FVC); CRC cis rs4662945 0.603 rs13002385 chr2:130276865 T/C cg05962382 chr2:130345044 NA -0.49 -8.54 -0.43 5.08e-16 Response to cytidine analogues (gemcitabine); CRC cis rs12580194 0.593 rs7959124 chr12:55726957 A/G cg23425280 chr12:56401806 NA 0.48 5.93 0.31 7.76e-9 Cancer; CRC cis rs1552244 1.000 rs9875081 chr3:10083935 G/A cg02579736 chr3:10068473 FANCD2;CIDECP 0.97 13.13 0.59 6.13e-32 Alzheimer's disease; CRC cis rs7044106 0.615 rs10818470 chr9:123359204 A/C cg14255062 chr9:123606675 PSMD5;LOC253039 0.39 5.9 0.31 8.8e-9 Hip circumference adjusted for BMI; CRC cis rs501120 0.584 rs1704226 chr10:44678387 C/A cg09554077 chr10:44749378 NA 0.7 7.85 0.4 5.95e-14 Coronary artery disease;Coronary heart disease; CRC cis rs826838 0.967 rs7970069 chr12:38810631 T/C cg26384229 chr12:38710491 ALG10B 0.75 10.46 0.5 2.69e-22 Heart rate; CRC cis rs11785693 0.862 rs62491191 chr8:4993460 G/A cg26367366 chr8:4980734 NA 0.8 9.87 0.48 2.64e-20 Neuroticism (multi-trait analysis);Neuroticism; CRC cis rs4601821 0.858 rs4938012 chr11:113259654 A/G cg14159747 chr11:113255604 NA 0.52 9.67 0.47 1.28e-19 Alcoholic chronic pancreatitis; CRC cis rs7666738 0.830 rs7657982 chr4:99044015 G/A cg17366294 chr4:99064904 C4orf37 0.45 7.71 0.39 1.48e-13 Colonoscopy-negative controls vs population controls; CRC cis rs10504229 0.906 rs66480865 chr8:58187100 C/T cg02725872 chr8:58115012 NA -0.38 -6.43 -0.33 4.44e-10 Developmental language disorder (linguistic errors); CRC cis rs870825 0.860 rs72689295 chr4:185600930 T/C cg04058563 chr4:185651563 MLF1IP 0.63 6.52 0.34 2.71e-10 Blood protein levels; CRC cis rs9660180 0.967 rs12034740 chr1:1728969 C/A cg13866156 chr1:1669148 SLC35E2 -0.6 -9.34 -0.46 1.54e-18 Body mass index; CRC cis rs12681288 0.792 rs4735972 chr8:998618 A/C cg15309053 chr8:964076 NA 0.41 7.93 0.4 3.36e-14 Schizophrenia; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg07355551 chr20:2489285 ZNF343 0.41 6.01 0.31 4.88e-9 Intelligence (multi-trait analysis); CRC cis rs7772486 0.754 rs857881 chr6:145970793 C/A cg05347473 chr6:146136440 FBXO30 -0.38 -5.7 -0.3 2.64e-8 Lobe attachment (rater-scored or self-reported); CRC cis rs11148252 0.744 rs4884354 chr13:53017474 T/C cg12458913 chr13:53173898 NA 0.52 7.93 0.4 3.56e-14 Lewy body disease; CRC cis rs1005277 0.505 rs719569 chr10:38154415 T/G cg25517755 chr10:38738941 LOC399744 0.45 6.6 0.34 1.62e-10 Extrinsic epigenetic age acceleration; CRC cis rs4713118 0.869 rs7773070 chr6:27728827 T/C cg03623178 chr6:28175578 NA 0.7 9.8 0.48 4.67e-20 Parkinson's disease; CRC trans rs634534 0.622 rs624273 chr11:65712413 A/G cg17712092 chr4:129076599 LARP1B 0.54 8.24 0.41 4.1e-15 Sum eosinophil basophil counts;Eosinophil counts; CRC cis rs1847505 0.609 rs9317154 chr13:61560533 A/G cg14094164 chr13:61491000 NA 0.33 6.22 0.32 1.47e-9 Polychlorinated biphenyl levels; CRC cis rs593982 0.920 rs1151500 chr11:65481166 T/C cg08755490 chr11:65554678 OVOL1 0.95 10.52 0.5 1.72e-22 Atopic dermatitis; CRC cis rs12594515 0.967 rs11070466 chr15:45984955 C/T cg22117107 chr15:45993392 NA -0.44 -8.91 -0.44 3.43e-17 Waist circumference;Weight; CRC trans rs7937682 0.889 rs542424 chr11:111477698 T/C cg18187862 chr3:45730750 SACM1L 0.47 6.78 0.35 5.68e-11 Primary sclerosing cholangitis; CRC trans rs728616 0.681 rs35014047 chr10:81912397 A/C cg18543242 chr14:23290393 SLC7A7 0.43 5.98 0.31 5.79e-9 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs6074578 0.902 rs6033484 chr20:185926 A/G cg16931068 chr20:139680 DEFB127 -0.29 -5.63 -0.3 3.8e-8 Hirschsprung disease; CRC cis rs9467711 0.559 rs6920256 chr6:26537801 G/A cg16898833 chr6:26189333 HIST1H4D 0.83 7.12 0.37 6.74e-12 Autism spectrum disorder or schizophrenia; CRC cis rs1552244 0.938 rs67667957 chr3:10167264 G/C cg00166722 chr3:10149974 C3orf24 0.67 8.87 0.44 4.81e-17 Alzheimer's disease; CRC cis rs6951245 0.572 rs74791540 chr7:1061913 C/A cg26224354 chr7:1096374 C7orf50;GPR146 -0.91 -7.81 -0.4 7.97e-14 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg06377221 chr19:18111739 ARRDC2 0.47 6.3 0.33 9.78e-10 Thyroid stimulating hormone; CRC cis rs3749237 0.964 rs11714957 chr3:49776178 C/T cg03060546 chr3:49711283 APEH 0.52 7.78 0.39 9.18e-14 Resting heart rate; CRC cis rs2832191 0.716 rs2249028 chr21:30365322 G/A cg08807101 chr21:30365312 RNF160 0.72 11.53 0.54 4.64e-26 Dental caries; CRC cis rs644799 0.965 rs11021313 chr11:95506907 G/C cg25622487 chr11:95524042 FAM76B;CEP57 0.75 11.51 0.54 5.3e-26 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs9393692 1.000 rs2393593 chr6:26285683 T/C cg00631329 chr6:26305371 NA -0.72 -13.42 -0.59 4.73e-33 Educational attainment; CRC cis rs8180040 0.966 rs7628631 chr3:47560863 C/T cg02527881 chr3:46936655 PTH1R 0.37 6.79 0.35 5.21e-11 Colorectal cancer; CRC cis rs4713118 0.568 rs9468213 chr6:27706180 G/A cg21251018 chr6:28226885 NKAPL 0.38 5.83 0.31 1.35e-8 Parkinson's disease; CRC cis rs117623576 0.941 rs72778716 chr10:32370541 G/A cg03047570 chr10:32398778 NA -0.74 -7.11 -0.37 7.1e-12 Anti-saccade response; CRC trans rs1814175 0.558 rs5025146 chr11:49795724 C/G cg03929089 chr4:120376271 NA -0.91 -15.65 -0.65 1.2e-41 Height; CRC cis rs8031584 0.560 rs7171208 chr15:31198929 A/G cg08704250 chr15:31115839 NA 0.33 6.0 0.31 5.24e-9 Huntington's disease progression; CRC cis rs6502050 0.871 rs62079994 chr17:80076516 T/C cg19223190 chr17:80058835 NA -0.41 -6.56 -0.34 2.07e-10 Life satisfaction; CRC trans rs2303319 0.504 rs12470830 chr2:162429996 C/T cg03757145 chr4:76555832 CDKL2 -0.68 -6.04 -0.32 4.06e-9 Cognitive function; CRC cis rs2739330 0.760 rs1007888 chr22:24241101 C/T cg10819733 chr22:24237672 NA -0.37 -6.39 -0.33 5.62e-10 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs1552244 0.572 rs67227131 chr3:10172744 G/A cg02579736 chr3:10068473 FANCD2;CIDECP 1.06 10.77 0.51 2.23e-23 Alzheimer's disease; CRC cis rs7224685 0.501 rs781823 chr17:3966280 G/C cg11204139 chr17:3907470 NA 0.75 14.23 0.62 3.77e-36 Type 2 diabetes; CRC cis rs4711336 0.638 rs4713664 chr6:33674198 A/G cg14003231 chr6:33640908 ITPR3 0.49 7.81 0.4 7.84e-14 Height; CRC cis rs9462846 0.919 rs9462851 chr6:42890602 A/G cg02353165 chr6:42928485 GNMT 0.47 6.42 0.33 4.81e-10 Blood protein levels; CRC cis rs9818758 0.545 rs55921200 chr3:49189316 T/C cg00383909 chr3:49044727 WDR6 1.38 11.14 0.52 1.16e-24 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg19318450 chr21:34852305 TMEM50B 0.41 7.17 0.37 5.12e-12 Liver disease severity in Alagille syndrome; CRC cis rs7666738 0.612 rs6830172 chr4:99093947 G/A cg05340658 chr4:99064831 C4orf37 0.51 7.51 0.38 5.58e-13 Colonoscopy-negative controls vs population controls; CRC cis rs853679 0.517 rs9468286 chr6:28079428 C/T cg12273811 chr6:28175739 NA 0.73 9.18 0.45 4.85e-18 Depression; CRC cis rs9467711 0.606 rs9366656 chr6:26434630 T/C cg14345882 chr6:26364793 BTN3A2 0.7 5.67 0.3 3.1e-8 Autism spectrum disorder or schizophrenia; CRC cis rs4253772 0.550 rs6007823 chr22:46706249 C/T cg03482458 chr22:46692211 CN5H6.4;GTSE1 0.48 6.15 0.32 2.26e-9 LDL cholesterol;Cholesterol, total; CRC cis rs7523050 0.730 rs34182354 chr1:109416340 C/T cg08274380 chr1:109419600 GPSM2 0.85 7.07 0.36 9.24e-12 Fat distribution (HIV); CRC cis rs35146811 0.961 rs11771139 chr7:99736059 C/T cg03265037 chr7:99691720 MIR25;MCM7;MIR106B;MIR93 0.46 5.9 0.31 8.88e-9 Coronary artery disease; CRC cis rs4930103 0.935 rs2071094 chr11:2021164 G/T cg23202291 chr11:1979235 NA 0.48 6.73 0.35 7.48e-11 DNA methylation (parent-of-origin);DNA methylation (variation); CRC cis rs2573652 1.000 rs11634977 chr15:100516472 G/A cg00587665 chr15:100533223 ADAMTS17 -0.39 -6.64 -0.34 1.26e-10 Height; CRC cis rs4474465 0.736 rs10899542 chr11:78246572 T/G cg02023728 chr11:77925099 USP35 -0.37 -6.27 -0.33 1.15e-9 Alzheimer's disease (survival time); CRC cis rs6912958 0.781 rs2207146 chr6:88180641 A/G cg08069147 chr6:88032118 GJB7;C6orf162 -0.54 -7.97 -0.4 2.68e-14 Monocyte percentage of white cells; CRC cis rs365302 1.000 rs2782552 chr6:159643696 G/T cg14500486 chr6:159655392 FNDC1 0.44 6.61 0.34 1.54e-10 Coronary heart disease; CRC cis rs965469 1.000 rs6051762 chr20:3321590 T/C cg25506879 chr20:3388711 C20orf194 -0.4 -5.74 -0.3 2.17e-8 IFN-related cytopenia; CRC cis rs2243480 1.000 rs313813 chr7:65503500 C/T cg12463550 chr7:65579703 CRCP 0.68 6.15 0.32 2.3e-9 Diabetic kidney disease; CRC cis rs1577917 0.958 rs11754330 chr6:86455070 G/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.61 -7.81 -0.4 7.86e-14 Response to antipsychotic treatment; CRC cis rs4363385 0.510 rs11488175 chr1:153039778 A/G cg25856811 chr1:152973957 SPRR3 0.23 6.29 0.33 1.04e-9 Inflammatory skin disease; CRC cis rs10045504 0.502 rs17456635 chr5:38745456 G/A cg15396434 chr5:38725168 NA -0.6 -6.01 -0.31 4.86e-9 Night sleep phenotypes; CRC cis rs10779751 0.960 rs1883965 chr1:11322156 A/G cg08854313 chr1:11322531 MTOR 0.67 9.49 0.46 4.9e-19 Body mass index; CRC cis rs2075371 1.000 rs447266 chr7:133989543 A/G cg20476274 chr7:133979776 SLC35B4 0.78 14.0 0.61 2.81e-35 Mean platelet volume; CRC cis rs2228479 0.850 rs17227057 chr16:89816333 C/T cg06656553 chr16:89960601 TCF25 -0.69 -5.74 -0.3 2.15e-8 Skin colour saturation; CRC trans rs7944735 1.000 rs7944735 chr11:47955608 G/C cg03929089 chr4:120376271 NA 0.56 6.51 0.34 2.73e-10 Intraocular pressure; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg01855760 chr4:68567075 LOC550112;UBA6 0.47 6.05 0.32 3.92e-9 Thyroid stimulating hormone; CRC cis rs889312 0.500 rs832585 chr5:56125904 T/C cg03609598 chr5:56110824 MAP3K1 -0.43 -6.04 -0.32 4.21e-9 Breast cancer;Breast cancer (early onset); CRC cis rs66782572 1 rs66782572 chr3:52567617 A/G cg08365687 chr3:52569147 NT5DC2;LOC440957 0.35 5.84 0.31 1.22e-8 Hemoglobin concentration; CRC trans rs8002861 0.641 rs4942252 chr13:44443039 C/T cg12856521 chr11:46389249 DGKZ 0.44 7.23 0.37 3.31e-12 Leprosy; CRC cis rs4132509 0.895 rs6674314 chr1:243920895 A/G cg21452805 chr1:244014465 NA 0.48 6.62 0.34 1.48e-10 RR interval (heart rate); CRC cis rs3087591 0.683 rs2525564 chr17:29652531 A/G cg24425628 chr17:29625626 OMG;NF1 0.74 13.21 0.59 2.86e-32 Hip circumference; CRC cis rs10504229 0.769 rs17804383 chr8:58151830 A/G cg21724239 chr8:58056113 NA 0.62 8.38 0.42 1.51e-15 Developmental language disorder (linguistic errors); CRC cis rs9611565 0.659 rs9607812 chr22:41941243 G/A cg06634786 chr22:41940651 POLR3H -0.66 -7.69 -0.39 1.77e-13 Vitiligo; CRC trans rs9825823 0.617 rs2083264 chr3:61074229 A/G cg14587446 chr7:150672364 KCNH2 0.39 6.26 0.33 1.17e-9 Depressive symptom measurement or major depressive disorder; CRC cis rs6963495 0.818 rs117887993 chr7:105193837 T/G cg13798780 chr7:105162888 PUS7 0.65 7.41 0.38 1.1e-12 Bipolar disorder (body mass index interaction); CRC cis rs6860806 1.000 rs6860806 chr5:131640536 C/T cg18758796 chr5:131593413 PDLIM4 -0.34 -6.2 -0.32 1.73e-9 Breast cancer; CRC cis rs9611565 0.918 rs9611566 chr22:41768625 A/G cg03806693 chr22:41940476 POLR3H 1.01 13.45 0.6 3.76e-33 Vitiligo; CRC cis rs10504229 1.000 rs115548028 chr8:58170672 T/C cg24829409 chr8:58192753 C8orf71 -0.68 -11.34 -0.53 2.27e-25 Developmental language disorder (linguistic errors); CRC cis rs2354432 0.714 rs7531962 chr1:146746023 G/A cg25205988 chr1:146714368 CHD1L -1.17 -14.11 -0.61 1.14e-35 Mitochondrial DNA levels; CRC cis rs6866344 0.561 rs55974982 chr5:178141421 G/A cg03877680 chr5:178157825 ZNF354A 0.77 11.07 0.52 2.09e-24 Neutrophil percentage of white cells; CRC cis rs9992667 0.955 rs60029573 chr4:38663863 T/C cg19726192 chr4:38663646 FLJ13197 -0.71 -9.02 -0.45 1.62e-17 Eosinophil percentage of granulocytes; CRC cis rs3764400 0.567 rs3897789 chr17:46312777 C/T cg10706073 chr17:46328419 SKAP1 -0.61 -6.65 -0.34 1.23e-10 Body mass index; CRC cis rs6456156 0.774 rs6456158 chr6:167528032 A/C cg19688584 chr6:167529678 CCR6 0.33 6.13 0.32 2.56e-9 Primary biliary cholangitis; CRC cis rs28386778 0.863 rs9207 chr17:61823899 C/T cg06601766 chr17:61851465 DDX42;CCDC47 0.44 5.98 0.31 5.83e-9 Prudent dietary pattern; CRC cis rs9649213 0.511 rs6950994 chr7:97887872 G/A cg00277769 chr7:97922759 BAIAP2L1 -0.58 -9.83 -0.48 3.71e-20 Prostate cancer (SNP x SNP interaction); CRC cis rs782590 0.774 rs782632 chr2:55898290 C/G cg18811423 chr2:55921094 PNPT1 0.85 16.24 0.67 6e-44 Metabolic syndrome; CRC cis rs6951245 1.000 rs78308415 chr7:1072634 G/A cg26224354 chr7:1096374 C7orf50;GPR146 -0.9 -11.26 -0.53 4.42e-25 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs8062405 0.722 rs3785354 chr16:28550667 C/T cg16576597 chr16:28551801 NUPR1 0.55 8.26 0.41 3.49e-15 Cognitive ability (multi-trait analysis);Cognitive ability; CRC cis rs7584330 0.554 rs77194105 chr2:238436463 T/C cg14458575 chr2:238380390 NA 0.8 10.05 0.48 6.61e-21 Prostate cancer; CRC cis rs9658691 0.920 rs2234768 chr10:90749943 T/C cg03111039 chr10:90751583 FAS;ACTA2 -0.87 -6.3 -0.33 9.41e-10 Mosquito bite size; CRC cis rs9291683 0.620 rs7699512 chr4:10125808 C/T cg00071950 chr4:10020882 SLC2A9 -0.48 -8.12 -0.41 9.38e-15 Bone mineral density; CRC cis rs262150 1.000 rs262150 chr7:158777934 G/A cg19418458 chr7:158789849 NA -0.44 -7.36 -0.38 1.46e-12 Facial morphology (factor 20); CRC cis rs9322193 0.923 rs9689084 chr6:149960784 G/A cg00933542 chr6:150070202 PCMT1 0.28 5.78 0.3 1.74e-8 Lung cancer; CRC cis rs7647973 0.626 rs9835157 chr3:49797769 G/A cg13072238 chr3:49761600 GMPPB 0.48 5.63 0.3 3.86e-8 Menarche (age at onset); CRC cis rs765787 0.530 rs28524974 chr15:45543528 C/T cg24006582 chr15:45444508 DUOX1 -0.52 -8.08 -0.41 1.26e-14 Uric acid levels; CRC trans rs11098499 0.955 rs56386062 chr4:120155135 T/C cg25214090 chr10:38739885 LOC399744 0.51 7.84 0.4 6.42e-14 Corneal astigmatism; CRC cis rs9902453 0.740 rs2628189 chr17:28088813 G/A cg26525008 chr17:28256777 EFCAB5;SSH2 -0.72 -12.08 -0.55 4.63e-28 Coffee consumption (cups per day); CRC cis rs13256369 1.000 rs7004438 chr8:8574379 C/T cg18904891 chr8:8559673 CLDN23 0.51 7.06 0.36 1.01e-11 Obesity-related traits; CRC cis rs9291683 0.609 rs4622999 chr4:10003395 C/G cg00071950 chr4:10020882 SLC2A9 0.66 12.54 0.57 9.6e-30 Bone mineral density; CRC cis rs10504229 0.728 rs17804750 chr8:58155751 T/C cg24829409 chr8:58192753 C8orf71 -0.58 -7.96 -0.4 2.86e-14 Developmental language disorder (linguistic errors); CRC cis rs9814567 1.000 rs4535272 chr3:134299916 A/G cg06109529 chr3:134205091 CEP63;ANAPC13 0.82 12.04 0.55 6.69e-28 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg16975973 chr12:77459865 E2F7 0.47 6.94 0.36 2.04e-11 Intelligence (multi-trait analysis); CRC cis rs9534288 0.830 rs7987953 chr13:46634395 C/T cg15192986 chr13:46630673 CPB2 -0.78 -10.96 -0.52 5.02e-24 Blood protein levels; CRC cis rs7412746 0.658 rs2272214 chr1:150931462 C/T cg17724175 chr1:150552817 MCL1 0.45 6.93 0.36 2.17e-11 Melanoma; CRC cis rs1878931 0.501 rs17136359 chr16:3420814 C/T cg26668626 chr16:3451006 ZNF174;ZNF434 -0.67 -9.04 -0.45 1.33e-17 Body mass index (adult); CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg26379672 chr3:4534954 ITPR1 0.46 6.06 0.32 3.7e-9 Anxiety disorder; CRC cis rs1448094 0.511 rs4462416 chr12:86150966 T/C cg25456477 chr12:86230367 RASSF9 -0.35 -5.9 -0.31 8.88e-9 Major depressive disorder; CRC cis rs3540 0.512 rs3862437 chr15:91084632 A/G cg22089800 chr15:90895588 ZNF774 -0.58 -9.5 -0.46 4.46e-19 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; CRC cis rs875971 1.000 rs2042133 chr7:65931922 A/G cg00343986 chr7:65444356 GUSB 0.43 6.29 0.33 1.03e-9 Aortic root size; CRC cis rs72634258 0.945 rs12736494 chr1:8136016 G/A cg00042356 chr1:8021962 PARK7 0.73 7.64 0.39 2.36e-13 Inflammatory bowel disease; CRC cis rs6879260 1.000 rs7706951 chr5:179733407 C/T cg23221052 chr5:179740743 GFPT2 -0.61 -9.36 -0.46 1.25e-18 Height; CRC cis rs11098499 0.954 rs1546505 chr4:120241224 A/G cg24375607 chr4:120327624 NA 0.5 7.61 0.39 2.84e-13 Corneal astigmatism; CRC cis rs703970 0.560 rs2802361 chr10:80971640 G/C cg20744163 chr10:80999841 ZMIZ1 -0.37 -6.04 -0.32 4.12e-9 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs4713118 0.591 rs2056924 chr6:27690174 G/A cg12273811 chr6:28175739 NA 0.45 6.56 0.34 2.06e-10 Parkinson's disease; CRC cis rs6860806 0.507 rs270608 chr5:131648406 C/T cg12564285 chr5:131593104 PDLIM4 0.48 7.98 0.4 2.45e-14 Breast cancer; CRC trans rs12599106 0.709 rs1501462 chr16:34964515 A/T cg03395511 chr6:291903 DUSP22 -0.64 -8.99 -0.44 1.97e-17 Menopause (age at onset); CRC cis rs172166 0.694 rs1770131 chr6:28086413 C/T cg06470822 chr6:28175283 NA 0.81 11.77 0.54 6.35e-27 Cardiac Troponin-T levels; CRC cis rs35110281 0.837 rs12627667 chr21:45071396 A/C cg01579765 chr21:45077557 HSF2BP -0.39 -7.48 -0.38 6.64e-13 Mean corpuscular volume; CRC trans rs507080 0.922 rs654792 chr11:118552996 A/C cg17272795 chr10:38382849 ZNF37A 0.41 5.97 0.31 6.08e-9 Serum metabolite levels; CRC cis rs17065868 1.000 rs9533920 chr13:45157394 G/A cg10246903 chr13:45222710 NA 0.53 5.95 0.31 6.84e-9 Antineutrophil cytoplasmic antibody-associated vasculitis; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg06717492 chr7:65447339 GUSB 0.42 6.89 0.36 2.9100000000000002e-11 Liver disease severity in Alagille syndrome; CRC cis rs2243480 1.000 rs6958420 chr7:65751171 A/G cg12463550 chr7:65579703 CRCP -0.68 -6.07 -0.32 3.43e-9 Diabetic kidney disease; CRC cis rs10504229 0.683 rs17802743 chr8:58105897 C/T cg08219700 chr8:58056026 NA 0.6 7.09 0.36 8.33e-12 Developmental language disorder (linguistic errors); CRC cis rs9443645 0.803 rs1547731 chr6:79776104 A/G cg09184832 chr6:79620586 NA -0.5 -9.12 -0.45 7.86e-18 Intelligence (multi-trait analysis); CRC cis rs751728 0.626 rs6457741 chr6:33756026 C/T cg25922239 chr6:33757077 LEMD2 0.46 6.86 0.35 3.49e-11 Crohn's disease; CRC cis rs826838 1.000 rs11168217 chr12:38884278 T/C cg13010199 chr12:38710504 ALG10B 0.46 6.01 0.31 4.91e-9 Heart rate; CRC cis rs637571 0.522 rs12792888 chr11:65761446 C/T cg17985854 chr11:65770987 BANF1;EIF1AD 0.52 8.61 0.43 3.02e-16 Eosinophil percentage of white cells; CRC cis rs4819052 0.808 rs2246697 chr21:46689999 G/A cg19498844 chr21:46707878 POFUT2;LOC642852 0.79 11.53 0.54 4.72e-26 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs1348850 0.519 rs13034781 chr2:178523550 C/A cg02961200 chr2:178257176 LOC100130691;AGPS 0.52 7.25 0.37 2.95e-12 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC trans rs10982213 0.830 rs2274163 chr9:117188714 C/T cg16856342 chr1:67895909 SERBP1 0.4 6.57 0.34 1.98e-10 Interleukin-6 levels; CRC cis rs7385804 0.761 rs507392 chr7:100319936 G/A cg16850897 chr7:100343110 ZAN 0.45 6.72 0.35 7.97e-11 Iron status biomarkers;Mean corpuscular hemoglobin;Hematocrit;Iron status biomarkers (transferrin saturation);Red blood cell count;Iron status biomarkers (iron levels);Mean corpuscular volume;Hematological parameters; CRC cis rs736801 0.808 rs72797303 chr5:131796163 T/C cg14196790 chr5:131705035 SLC22A5 0.35 5.61 0.3 4.37e-8 Breast cancer;Mosquito bite size; CRC cis rs7666738 0.830 rs10010698 chr4:98981594 C/T cg05340658 chr4:99064831 C4orf37 0.58 8.82 0.44 6.61e-17 Colonoscopy-negative controls vs population controls; CRC cis rs3733585 0.673 rs7375587 chr4:9954758 A/T cg11266682 chr4:10021025 SLC2A9 0.46 9.53 0.47 3.52e-19 Cleft plate (environmental tobacco smoke interaction); CRC cis rs9649213 0.593 rs6969234 chr7:97987986 T/C cg08684580 chr7:98029266 BAIAP2L1 -0.32 -5.67 -0.3 3.09e-8 Prostate cancer (SNP x SNP interaction); CRC cis rs2354432 0.607 rs7553584 chr1:146693429 A/G cg25205988 chr1:146714368 CHD1L -0.92 -8.27 -0.41 3.43e-15 Mitochondrial DNA levels; CRC cis rs1552244 0.882 rs17050672 chr3:10025463 G/A cg13047869 chr3:10149882 C3orf24 0.51 6.39 0.33 5.63e-10 Alzheimer's disease; CRC cis rs10504229 1.000 rs59383954 chr8:58189689 G/A cg01721255 chr8:58191610 C8orf71 0.49 6.17 0.32 2e-9 Developmental language disorder (linguistic errors); CRC trans rs1997103 1.000 rs1997098 chr7:55405594 G/T cg20935933 chr6:143382018 AIG1 0.51 6.64 0.34 1.3e-10 QRS interval (sulfonylurea treatment interaction); CRC cis rs478304 0.654 rs6591187 chr11:65460086 C/G cg27068330 chr11:65405492 SIPA1 -0.67 -9.92 -0.48 1.81e-20 Acne (severe); CRC cis rs3825932 0.961 rs2870085 chr15:79234268 T/C cg25744700 chr15:79237217 CTSH 0.39 6.08 0.32 3.42e-9 Type 1 diabetes; CRC cis rs7296418 0.961 rs4148862 chr12:123568619 A/C cg00376283 chr12:123451042 ABCB9 0.64 9.8 0.48 4.75e-20 Platelet count; CRC cis rs7781266 0.847 rs889824 chr7:133596581 A/G cg03336402 chr7:133662267 EXOC4 -0.59 -7.76 -0.39 1.08e-13 Educational attainment (college completion); CRC cis rs6952808 0.656 rs11764212 chr7:2067593 C/A cg21782813 chr7:2030301 MAD1L1 0.56 9.43 0.46 7.82e-19 Bipolar disorder and schizophrenia; CRC cis rs28386778 0.830 rs2854210 chr17:61946338 C/A cg11494091 chr17:61959527 GH2 0.6 10.1 0.49 4.69e-21 Prudent dietary pattern; CRC cis rs67478160 0.595 rs8022783 chr14:104245573 T/C cg08213375 chr14:104286397 PPP1R13B 0.65 13.73 0.6 3.2e-34 Schizophrenia; CRC cis rs561341 1.000 rs560132 chr17:30320019 C/T cg12193833 chr17:30244370 NA -0.74 -8.7 -0.43 1.61e-16 Hip circumference adjusted for BMI; CRC cis rs9611565 0.659 rs1810460 chr22:41927700 C/T cg17554472 chr22:41940697 POLR3H -0.52 -5.6 -0.3 4.42e-8 Vitiligo; CRC cis rs11971779 0.941 rs7800795 chr7:139080348 A/G cg07862535 chr7:139043722 LUC7L2 1.05 12.55 0.57 8.75e-30 Diisocyanate-induced asthma; CRC cis rs13108904 0.846 rs3775100 chr4:1225106 T/C cg20887711 chr4:1340912 KIAA1530 0.42 6.14 0.32 2.4e-9 Obesity-related traits; CRC cis rs68170813 0.641 rs77397573 chr7:107006892 G/A cg02696742 chr7:106810147 HBP1 -0.57 -6.36 -0.33 6.71e-10 Coronary artery disease; CRC cis rs4742903 0.967 rs10512325 chr9:106861191 C/T cg21169611 chr9:106856078 SMC2 0.42 5.83 0.31 1.31e-8 High-grade serous ovarian cancer;Breast cancer; CRC cis rs13256369 0.901 rs12679831 chr8:8566411 T/G cg18904891 chr8:8559673 CLDN23 0.54 7.06 0.36 1.03e-11 Obesity-related traits; CRC cis rs7666738 0.830 rs1813972 chr4:98886828 C/A cg05340658 chr4:99064831 C4orf37 0.56 8.41 0.42 1.28e-15 Colonoscopy-negative controls vs population controls; CRC cis rs9916302 0.851 rs9909064 chr17:37500434 G/T cg07936489 chr17:37558343 FBXL20 0.79 11.88 0.55 2.48e-27 Glomerular filtration rate (creatinine); CRC cis rs6540556 0.769 rs17389198 chr1:209922058 G/A cg05527609 chr1:210001259 C1orf107 -0.57 -6.38 -0.33 6.07e-10 Red blood cell count; CRC cis rs35306767 0.633 rs17221491 chr10:1065191 A/G cg26597838 chr10:835615 NA 0.85 9.64 0.47 1.51e-19 Eosinophil percentage of granulocytes; CRC cis rs763121 0.853 rs5757141 chr22:38957483 G/A cg06544989 chr22:39130855 UNC84B 0.42 6.17 0.32 2.03e-9 Menopause (age at onset); CRC cis rs763014 0.966 rs15564 chr16:677854 G/T cg08989290 chr16:615782 NHLRC4 0.5 9.9 0.48 2.1e-20 Height; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg26329349 chr8:67974458 COPS5 0.42 5.96 0.31 6.48e-9 Response to antipsychotic treatment; CRC cis rs112158604 1 rs112158604 chr1:150696792 TCTTCTGCAG/T cg18016565 chr1:150552671 MCL1 -0.42 -6.26 -0.33 1.22e-9 Lymphocyte counts; CRC cis rs6762 0.719 rs28620453 chr11:836971 G/C cg03116740 chr11:841335 TSPAN4;POLR2L -0.42 -7.22 -0.37 3.58e-12 Mean platelet volume; CRC cis rs3791556 0.898 rs3791549 chr2:240109024 A/G cg03281426 chr2:240109471 HDAC4 -0.72 -9.22 -0.45 3.61e-18 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs1865760 0.566 rs9358902 chr6:26058570 C/G cg17691542 chr6:26056736 HIST1H1C 0.55 8.26 0.41 3.61e-15 Height; CRC cis rs875971 0.638 rs801216 chr7:66011667 T/C cg11764359 chr7:65958608 NA -0.55 -8.6 -0.43 3.21e-16 Aortic root size; CRC cis rs769267 0.929 rs34538000 chr19:19481379 G/T cg01262667 chr19:19385393 TM6SF2 -0.38 -6.33 -0.33 7.89e-10 Tonsillectomy; CRC cis rs9325144 0.560 rs7980358 chr12:38640396 C/G cg26384229 chr12:38710491 ALG10B 0.55 8.22 0.41 4.61e-15 Morning vs. evening chronotype; CRC cis rs9291683 0.609 rs7678012 chr4:9993772 T/C cg00071950 chr4:10020882 SLC2A9 0.6 11.29 0.53 3.36e-25 Bone mineral density; CRC cis rs41005 1.000 rs41008 chr2:8108588 G/T cg03155496 chr2:8117019 LOC339788 0.42 7.45 0.38 8.06e-13 Response to anti-TNF therapy in rheumatoid arthritis; CRC cis rs4664293 0.867 rs10204867 chr2:160589185 C/A cg08347373 chr2:160653686 CD302 -0.47 -7.43 -0.38 9.32e-13 Monocyte percentage of white cells; CRC cis rs4722166 0.630 rs4722169 chr7:22785419 C/T cg26061582 chr7:22766209 IL6 0.55 8.34 0.42 2.03e-15 Lung cancer; CRC cis rs4713118 0.621 rs9368548 chr6:28034737 A/G cg03623178 chr6:28175578 NA 0.89 11.72 0.54 9.49e-27 Parkinson's disease; CRC trans rs6703335 0.870 rs10803142 chr1:243598234 A/G cg24268822 chr3:49059985 NDUFAF3 0.44 6.19 0.32 1.77e-9 Schizophrenia;Schizophrenia, schizoaffective disorder or bipolar disorder; CRC trans rs561341 0.769 rs559228 chr17:30294527 T/C cg27661571 chr11:113659931 NA -0.95 -11.08 -0.52 1.91e-24 Hip circumference adjusted for BMI; CRC cis rs7666738 0.791 rs10005118 chr4:99038196 A/C cg05340658 chr4:99064831 C4orf37 0.61 9.47 0.46 5.78e-19 Colonoscopy-negative controls vs population controls; CRC cis rs2223471 0.905 rs2817414 chr6:50748813 G/A cg03432817 chr6:50765336 NA 0.37 5.8 0.3 1.52e-8 Subcutaneous adipose tissue; CRC cis rs2735413 0.846 rs12923626 chr16:78080139 A/C cg04733911 chr16:78082701 NA -0.45 -7.44 -0.38 8.84e-13 Systolic blood pressure (alcohol consumption interaction); CRC cis rs7666738 1.000 rs13106934 chr4:99028685 C/T cg05340658 chr4:99064831 C4orf37 0.52 7.32 0.37 1.86e-12 Colonoscopy-negative controls vs population controls; CRC cis rs2842992 0.724 rs1128670 chr6:160211636 G/A cg11366901 chr6:160182831 ACAT2 0.73 10.92 0.52 6.54e-24 Age-related macular degeneration (geographic atrophy); CRC cis rs6500602 0.701 rs8053770 chr16:4539030 T/A cg08645402 chr16:4508243 NA 0.59 9.45 0.46 6.76e-19 Schizophrenia; CRC cis rs1355223 0.506 rs7130774 chr11:34869267 A/G cg11058730 chr11:34937778 PDHX;APIP -0.43 -6.03 -0.32 4.46e-9 Systemic lupus erythematosus and Systemic sclerosis; CRC cis rs13108904 0.901 rs6851528 chr4:1296009 G/A cg20887711 chr4:1340912 KIAA1530 0.43 6.25 0.33 1.28e-9 Obesity-related traits; CRC cis rs9486719 0.948 rs6920913 chr6:96874297 A/G cg06623918 chr6:96969491 KIAA0776 0.81 10.27 0.49 1.2e-21 Migraine;Coronary artery disease; CRC cis rs12497850 0.864 rs4955410 chr3:49181218 A/G cg20833759 chr3:49053208 WDR6;DALRD3 0.42 6.8 0.35 5.07e-11 Parkinson's disease; CRC trans rs1814175 0.645 rs4598671 chr11:50003191 C/A cg11707556 chr5:10655725 ANKRD33B -0.52 -10.25 -0.49 1.36e-21 Height; CRC cis rs17209837 0.607 rs1558375 chr7:87079069 T/C cg00919237 chr7:87102261 ABCB4 -0.53 -7.07 -0.36 9.33e-12 Gallbladder cancer; CRC trans rs2303319 0.504 rs62189051 chr2:162622318 G/A cg14875682 chr5:52083620 ITGA1;PELO -0.73 -6.12 -0.32 2.59e-9 Cognitive function; CRC cis rs4499344 0.633 rs259260 chr19:33153261 G/A cg08127369 chr19:33164662 ANKRD27 0.39 5.95 0.31 6.82e-9 Mean platelet volume; CRC cis rs7772486 0.727 rs11155442 chr6:146140725 T/C cg05347473 chr6:146136440 FBXO30 0.4 6.04 0.32 4.13e-9 Lobe attachment (rater-scored or self-reported); CRC trans rs11098499 0.754 rs10518300 chr4:120249499 G/T cg25214090 chr10:38739885 LOC399744 -0.54 -8.65 -0.43 2.26e-16 Corneal astigmatism; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg08039281 chr14:35761689 PSMA6 0.47 6.05 0.32 3.88e-9 Thyroid stimulating hormone; CRC cis rs875971 1.000 rs937495 chr7:65779798 A/G cg11764359 chr7:65958608 NA -0.63 -10.05 -0.48 6.6e-21 Aortic root size; CRC cis rs853679 1.000 rs1679732 chr6:28221264 G/A cg15786705 chr6:28176104 NA -0.58 -5.96 -0.31 6.43e-9 Depression; CRC cis rs1005277 0.579 rs2472181 chr10:38386764 T/C cg25427524 chr10:38739819 LOC399744 -0.77 -13.64 -0.6 6.85e-34 Extrinsic epigenetic age acceleration; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg20652235 chr19:47747597 NA 0.46 6.16 0.32 2.1e-9 Anxiety disorder; CRC cis rs6662572 0.542 rs72677553 chr1:46592278 C/T cg08644498 chr1:46502608 NA 0.46 7.31 0.37 2.11e-12 Blood protein levels; CRC trans rs11098499 0.909 rs28571712 chr4:120375980 G/A cg25214090 chr10:38739885 LOC399744 0.66 10.45 0.5 2.84e-22 Corneal astigmatism; CRC cis rs1555895 0.576 rs12413228 chr10:849230 G/T cg10556349 chr10:835070 NA -0.38 -7.44 -0.38 8.7e-13 Survival in rectal cancer; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg01581637 chr12:49463804 RHEBL1 0.47 6.69 0.35 9.83e-11 Anxiety disorder; CRC cis rs375066 0.623 rs6509120 chr19:44350205 C/T cg19542119 chr19:44331823 ZNF283 0.4 5.61 0.3 4.24e-8 Breast cancer; CRC cis rs73195822 0.614 rs73194061 chr12:111221941 T/C cg12870014 chr12:110450643 ANKRD13A 0.63 6.98 0.36 1.61e-11 Itch intensity from mosquito bite; CRC cis rs737008 0.922 rs2550475 chr16:11371986 C/T cg00044050 chr16:11439710 C16orf75 0.51 6.76 0.35 6.4e-11 Obesity-related traits; CRC cis rs798554 0.679 rs1639066 chr7:2892972 A/G cg04166393 chr7:2884313 GNA12 0.55 7.53 0.38 4.84e-13 Height; CRC trans rs7819412 0.691 rs73198970 chr8:11040216 T/C cg16141378 chr3:129829833 LOC729375 0.41 6.35 0.33 7.24e-10 Triglycerides; CRC cis rs9287719 0.934 rs4622695 chr2:10744327 C/T cg00105475 chr2:10696890 NA 0.45 7.3 0.37 2.2e-12 Prostate cancer; CRC cis rs6120849 0.754 rs6088678 chr20:33607551 A/G cg24642439 chr20:33292090 TP53INP2 -0.43 -5.65 -0.3 3.56e-8 Protein C levels; CRC cis rs9435341 0.965 rs1335055 chr1:107624563 A/G cg14671364 chr1:107599128 PRMT6 0.48 6.81 0.35 4.79e-11 Facial morphology (factor 21, depth of nasal alae); CRC cis rs9462027 0.606 rs7768759 chr6:34795685 A/T cg07306190 chr6:34760872 UHRF1BP1 -0.35 -6.13 -0.32 2.45e-9 Systemic lupus erythematosus; CRC cis rs7772486 0.754 rs1415747 chr6:146077249 A/G cg05347473 chr6:146136440 FBXO30 0.39 5.81 0.3 1.5e-8 Lobe attachment (rater-scored or self-reported); CRC trans rs1814175 0.527 rs3974435 chr11:49619533 G/A cg03929089 chr4:120376271 NA -0.75 -10.27 -0.49 1.17e-21 Height; CRC cis rs2463822 1.000 rs2513747 chr11:62098735 T/C cg06239285 chr11:62104954 ASRGL1 0.98 11.6 0.54 2.54e-26 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs10504229 0.815 rs17805008 chr8:58160185 G/T cg21724239 chr8:58056113 NA 0.64 8.39 0.42 1.46e-15 Developmental language disorder (linguistic errors); CRC cis rs6938 0.618 rs11857695 chr15:75165751 G/T cg05627522 chr15:75251581 NA 0.37 5.71 0.3 2.55e-8 Breast cancer; CRC cis rs9894429 0.646 rs7406825 chr17:79619188 C/T cg09655341 chr17:79618100 PDE6G -0.36 -6.16 -0.32 2.15e-9 Eye color traits; CRC cis rs7086627 0.515 rs11202959 chr10:82209672 A/G cg09626299 chr10:82213104 TSPAN14 -0.37 -6.23 -0.33 1.39e-9 Post bronchodilator FEV1; CRC cis rs2032447 0.802 rs199755 chr6:25990367 G/A cg04800585 chr6:26043546 HIST1H2BB 0.58 8.57 0.43 4.07e-16 Intelligence (multi-trait analysis); CRC trans rs12599106 0.770 rs12445057 chr16:34970274 C/G cg18110333 chr6:292329 DUSP22 -0.68 -9.93 -0.48 1.69e-20 Menopause (age at onset); CRC cis rs6500602 0.648 rs7702 chr16:4560929 G/C cg13763550 chr16:4524223 NMRAL1;HMOX2 0.48 6.13 0.32 2.58e-9 Schizophrenia; CRC cis rs4423214 1.000 rs2040323 chr11:71172783 A/C cg05163923 chr11:71159392 DHCR7 0.65 9.22 0.45 3.53e-18 Vitamin D levels; CRC cis rs67981189 0.529 rs17108808 chr14:71441552 T/C cg15910301 chr14:71632612 NA 0.28 5.67 0.3 3.11e-8 Schizophrenia; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg03113121 chr19:46366686 FOXA3;SYMPK 0.47 6.84 0.35 3.97e-11 Intelligence (multi-trait analysis); CRC cis rs4727027 0.801 rs12666337 chr7:148796253 C/T cg12479418 chr7:148823350 ZNF425;ZNF398 0.46 6.29 0.33 1.03e-9 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC cis rs2455826 0.500 rs2455852 chr3:15688688 C/T cg16303742 chr3:15540471 COLQ -0.38 -5.97 -0.31 6.23e-9 Inflammatory skin disease; CRC cis rs9463078 0.605 rs9472407 chr6:44908800 T/C cg25276700 chr6:44698697 NA 0.25 6.06 0.32 3.74e-9 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; CRC cis rs7481584 0.624 rs397919 chr11:3063094 A/C cg25174290 chr11:3078921 CARS -0.43 -6.03 -0.32 4.49e-9 Calcium levels; CRC trans rs2898290 0.540 rs35005793 chr8:11450472 G/A cg06636001 chr8:8085503 FLJ10661 0.54 7.61 0.39 2.99e-13 Systolic blood pressure; CRC cis rs7666738 0.791 rs10005118 chr4:99038196 A/C cg17366294 chr4:99064904 C4orf37 0.44 7.43 0.38 9.65e-13 Colonoscopy-negative controls vs population controls; CRC cis rs11809207 0.574 rs2783630 chr1:26504741 G/A cg00147160 chr1:26503991 CNKSR1 0.3 6.24 0.33 1.35e-9 Height; CRC cis rs7119 0.717 rs8042307 chr15:77804013 A/G cg27398640 chr15:77910606 LINGO1 -0.44 -7.66 -0.39 2.12e-13 Type 2 diabetes; CRC cis rs1552244 1.000 rs6786638 chr3:10118075 G/C cg08888203 chr3:10149979 C3orf24 0.73 10.16 0.49 2.86e-21 Alzheimer's disease; CRC cis rs1348850 0.574 rs4893834 chr2:178442288 C/T cg27490568 chr2:178487706 NA -0.51 -6.63 -0.34 1.39e-10 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs11997175 0.574 rs58858314 chr8:33658221 T/C ch.8.33884649F chr8:33765107 NA 0.5 8.04 0.41 1.65e-14 Body mass index; CRC cis rs10751667 0.643 rs6597970 chr11:928669 C/A cg23136738 chr11:925521 AP2A2 -0.41 -6.72 -0.35 8.1e-11 Alzheimer's disease (late onset); CRC cis rs2842992 0.830 rs1475123 chr6:160178007 A/G cg16489826 chr6:160211363 TCP1;MRPL18 0.45 5.86 0.31 1.15e-8 Age-related macular degeneration (geographic atrophy); CRC cis rs9303401 1.000 rs1390006 chr17:56890663 C/T cg10487724 chr17:56770010 TEX14;RAD51C -0.55 -8.02 -0.4 1.84e-14 Cognitive test performance; CRC cis rs4664293 0.867 rs12623283 chr2:160593470 A/G cg08347373 chr2:160653686 CD302 -0.47 -7.43 -0.38 9.32e-13 Monocyte percentage of white cells; CRC cis rs2228479 0.850 rs11641147 chr16:89813589 C/T cg06656553 chr16:89960601 TCF25 -0.69 -5.74 -0.3 2.15e-8 Skin colour saturation; CRC cis rs1552244 0.935 rs6805869 chr3:10119917 T/C cg13047869 chr3:10149882 C3orf24 0.53 7.53 0.38 5e-13 Alzheimer's disease; CRC cis rs1153858 0.621 rs12913645 chr15:45555066 G/A cg21132104 chr15:45694354 SPATA5L1 -0.54 -7.05 -0.36 1.04e-11 Homoarginine levels; CRC cis rs910316 0.763 rs175016 chr14:75459633 C/T cg08847533 chr14:75593920 NEK9 -0.85 -14.44 -0.62 6.1e-37 Height; CRC cis rs295137 0.836 rs1217429 chr2:201094151 G/T cg23649088 chr2:200775458 C2orf69 0.39 5.63 0.3 3.83e-8 Asthma (bronchodilator response); CRC cis rs977987 0.800 rs11645329 chr16:75336679 C/G cg03315344 chr16:75512273 CHST6 0.54 9.02 0.45 1.65e-17 Dupuytren's disease; CRC cis rs1008375 0.872 rs6831115 chr4:17640463 A/G cg04450456 chr4:17643702 FAM184B 0.4 6.51 0.34 2.81e-10 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs2411233 1.000 rs8026431 chr15:39274261 C/A cg23129342 chr15:39283510 NA 0.32 5.91 0.31 8.53e-9 Platelet count; CRC cis rs9858542 1.000 rs9812791 chr3:49682311 G/A cg00383909 chr3:49044727 WDR6 0.47 5.89 0.31 9.58e-9 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs13191362 0.810 rs13209784 chr6:162961274 T/C cg06582575 chr6:163149167 PACRG;PARK2 0.81 10.05 0.48 6.91e-21 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs4332037 0.510 rs11762803 chr7:1886805 A/G cg23378565 chr7:2036160 MAD1L1 -0.36 -6.13 -0.32 2.57e-9 Bipolar disorder; CRC cis rs7937682 1.000 rs7121011 chr11:111568681 C/T cg19812747 chr11:111475976 SIK2 0.54 8.54 0.43 5.03e-16 Primary sclerosing cholangitis; CRC cis rs11864453 0.927 rs1035560 chr16:72032730 T/C cg23815491 chr16:72088622 HP 0.55 8.17 0.41 6.61e-15 Fibrinogen levels; CRC cis rs1862618 0.671 rs2591970 chr5:56232595 T/C cg18230493 chr5:56204884 C5orf35 0.6 8.72 0.43 1.39e-16 Initial pursuit acceleration; CRC cis rs8044995 0.563 rs2279540 chr16:68395061 T/C cg09835421 chr16:68378352 PRMT7 -0.78 -8.1 -0.41 1.12e-14 Schizophrenia; CRC cis rs9394438 0.628 rs4714080 chr6:37544618 A/G cg00985040 chr6:37553208 NA 0.37 6.23 0.33 1.39e-9 IgG glycosylation; CRC cis rs314370 0.855 rs76181418 chr7:100494960 G/T cg10426581 chr7:100472382 SRRT 0.62 7.11 0.36 7.24e-12 Resting heart rate; CRC cis rs4713118 0.615 rs57252182 chr6:27720249 C/A cg12172441 chr6:28176163 NA 0.47 6.53 0.34 2.44e-10 Parkinson's disease; CRC cis rs13082711 0.906 rs34775440 chr3:27447333 G/T cg02860705 chr3:27208620 NA 0.62 8.74 0.43 1.17e-16 Systolic blood pressure;Diastolic blood pressure;Blood pressure; CRC cis rs10840133 1 rs10840133 chr11:8846369 G/A cg21881798 chr11:8931708 C11orf17;ST5 0.46 6.83 0.35 4.15e-11 Reticulocyte fraction of red cells; CRC cis rs875971 0.862 rs35378740 chr7:65987712 C/A cg12463550 chr7:65579703 CRCP 0.47 6.45 0.33 4.03e-10 Aortic root size; CRC cis rs4700695 0.841 rs251300 chr5:65299715 C/G cg21114390 chr5:65439923 SFRS12 -0.57 -7.02 -0.36 1.28e-11 Facial morphology (factor 19); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg00090800 chr16:27325237 IL4R 0.38 6.06 0.32 3.64e-9 Liver disease severity in Alagille syndrome; CRC cis rs4970988 0.556 rs2280078 chr1:150600181 C/T cg15448220 chr1:150897856 SETDB1 -0.44 -6.24 -0.33 1.34e-9 Urate levels; CRC cis rs1681630 0.545 rs12790666 chr11:47983477 G/A cg05585544 chr11:47624801 NA -0.43 -7.24 -0.37 3.27e-12 Height; CRC cis rs5769765 0.955 rs9616367 chr22:50303515 A/C cg02269571 chr22:50332266 NA -0.56 -7.53 -0.38 4.95e-13 Schizophrenia; CRC cis rs2412819 0.597 rs78282429 chr15:43922003 C/T cg02155558 chr15:43621948 ADAL;LCMT2 0.48 6.87 0.35 3.28e-11 Lung cancer; CRC cis rs1862618 0.511 rs2591952 chr5:56120769 T/A cg18230493 chr5:56204884 C5orf35 -0.69 -8.9 -0.44 3.93e-17 Initial pursuit acceleration; CRC cis rs3768617 0.782 rs10752893 chr1:183046261 C/T ch.1.3577855R chr1:183094577 LAMC1 0.64 9.41 0.46 8.79e-19 Fuchs's corneal dystrophy; CRC cis rs9868809 0.881 rs13324142 chr3:48669447 C/T cg00383909 chr3:49044727 WDR6 0.67 6.81 0.35 4.78e-11 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; CRC cis rs10504229 0.683 rs55868006 chr8:58135703 C/T cg22535103 chr8:58192502 C8orf71 -0.7 -9.34 -0.46 1.47e-18 Developmental language disorder (linguistic errors); CRC trans rs4650994 1.000 rs10913572 chr1:178526718 C/T cg05059571 chr16:84539110 KIAA1609 -0.45 -6.82 -0.35 4.36e-11 HDL cholesterol levels;HDL cholesterol; CRC cis rs11122272 0.735 rs2739509 chr1:231526765 C/T cg06096015 chr1:231504339 EGLN1 0.4 6.04 0.32 4.26e-9 Hemoglobin concentration; CRC cis rs4731207 0.564 rs6960622 chr7:124654080 G/A cg23710748 chr7:124431027 NA -0.39 -6.24 -0.33 1.35e-9 Cutaneous malignant melanoma; CRC cis rs7927592 1.000 rs7927592 chr11:68369960 G/A cg01657329 chr11:68192670 LRP5 -0.49 -7.03 -0.36 1.19e-11 Total body bone mineral density; CRC cis rs3617 0.625 rs2535633 chr3:52859630 C/G cg15147215 chr3:52552868 STAB1 0.54 9.47 0.46 5.65e-19 Red blood cell count;Autism spectrum disorder or schizophrenia; CRC cis rs924607 1.000 rs4045344 chr5:595870 G/T cg24163568 chr5:669837 TPPP -0.42 -6.71 -0.35 8.41e-11 Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia; CRC cis rs11212617 0.934 rs609557 chr11:108084513 G/T cg12106634 chr11:108092400 ATM;NPAT 0.4 6.15 0.32 2.2e-9 Response to metformin in type 2 diabetes (glycemic); CRC cis rs9487051 0.872 rs1521908 chr6:109613986 T/C cg12927641 chr6:109611667 NA -0.37 -6.72 -0.35 7.95e-11 Reticulocyte fraction of red cells; CRC cis rs9372498 0.505 rs17080456 chr6:118985938 G/C cg24463073 chr6:118973353 C6orf204 0.5 6.41 0.33 4.91e-10 Diastolic blood pressure; CRC cis rs3091242 0.900 rs1811832 chr1:25753565 G/A cg20684491 chr1:25596433 NA 0.42 7.54 0.38 4.7e-13 Erythrocyte sedimentation rate; CRC cis rs1448094 0.512 rs7313035 chr12:86250100 C/G cg19622623 chr12:86230825 RASSF9 -0.41 -6.76 -0.35 6.45e-11 Major depressive disorder; CRC cis rs7259376 0.905 rs7258446 chr19:22550341 A/T cg02657401 chr19:22469223 NA -0.33 -7.19 -0.37 4.28e-12 Menopause (age at onset); CRC cis rs9517320 0.967 rs7997785 chr13:99127985 T/A cg07423050 chr13:99094983 FARP1 0.41 6.57 0.34 1.93e-10 Longevity; CRC cis rs6502050 0.835 rs8078795 chr17:80126320 C/T cg19223190 chr17:80058835 NA 0.39 6.21 0.32 1.63e-9 Life satisfaction; CRC cis rs611744 0.647 rs2859813 chr8:109263497 G/A cg18478394 chr8:109455254 TTC35 0.38 5.81 0.31 1.46e-8 Dupuytren's disease; CRC cis rs3750965 0.920 rs10896421 chr11:68863048 T/C cg06818126 chr11:68850279 TPCN2 -0.47 -6.64 -0.34 1.26e-10 Hair color; CRC cis rs4713118 0.955 rs9368528 chr6:27683798 G/A cg15845792 chr6:28175446 NA 0.6 7.95 0.4 3.01e-14 Parkinson's disease; CRC cis rs892961 0.867 rs312909 chr17:75413954 T/C cg05865280 chr17:75406074 SEPT9 0.62 14.21 0.62 4.69e-36 Airflow obstruction; CRC cis rs853679 0.550 rs1233701 chr6:28168726 C/G cg12273811 chr6:28175739 NA -0.76 -11.04 -0.52 2.59e-24 Depression; CRC cis rs2180341 0.960 rs7766942 chr6:127691323 G/T cg27446573 chr6:127587934 RNF146 0.94 13.54 0.6 1.62e-33 Breast cancer; CRC cis rs58688157 0.705 rs2396545 chr11:601785 T/C cg09218773 chr11:619014 MUPCDH -0.41 -6.16 -0.32 2.16e-9 Systemic lupus erythematosus; CRC cis rs3862030 0.720 rs11593583 chr10:104228149 A/G cg11453585 chr10:104263688 ACTR1A;SUFU 0.76 12.94 0.58 3.18e-31 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for body mass index; CRC cis rs34172651 0.917 rs12599173 chr16:24823619 T/C cg06028605 chr16:24865363 SLC5A11 0.37 6.87 0.35 3.21e-11 Intelligence (multi-trait analysis); CRC cis rs4728302 0.869 rs10224575 chr7:133590875 G/A cg03336402 chr7:133662267 EXOC4 -0.44 -6.41 -0.33 4.91e-10 Intelligence;Intelligence (multi-trait analysis); CRC cis rs972578 1.000 rs972578 chr22:43387695 G/T cg01576275 chr22:43409880 NA -0.49 -7.89 -0.4 4.45e-14 Mean platelet volume; CRC cis rs7493 1.000 rs2299263 chr7:95040411 A/G cg04155289 chr7:94953770 PON1 0.6 7.55 0.38 4.39e-13 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs9875589 0.509 rs2733556 chr3:14100172 A/T cg14375111 chr3:14165186 TMEM43;CHCHD4 0.41 6.04 0.32 4.19e-9 Ovarian reserve; CRC cis rs9549328 0.564 rs34556022 chr13:113617437 G/A cg25790453 chr13:113633590 MCF2L 0.44 7.62 0.39 2.7e-13 Systolic blood pressure; CRC cis rs57994353 0.897 rs11999609 chr9:139363539 C/T cg14119001 chr9:139324193 INPP5E -0.44 -6.19 -0.32 1.75e-9 Eosinophil counts;Cutaneous squamous cell carcinoma; CRC cis rs6840360 0.718 rs2136960 chr4:152746189 A/G cg09659197 chr4:152720779 NA -0.41 -8.78 -0.44 9.31e-17 Intelligence (multi-trait analysis); CRC cis rs473651 0.935 rs10170056 chr2:239339291 G/C cg08773314 chr2:239334832 ASB1 0.37 7.76 0.39 1.11e-13 Multiple system atrophy; CRC cis rs6951245 1.000 rs11763793 chr7:1094342 A/G cg22907277 chr7:1156413 C7orf50 0.73 7.69 0.39 1.75e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs1997103 1.000 rs9649857 chr7:55411777 C/T cg17469321 chr7:55412551 NA 0.72 11.16 0.52 9.35e-25 QRS interval (sulfonylurea treatment interaction); CRC cis rs78456975 0.941 rs13423300 chr2:1553809 C/A cg01028140 chr2:1542097 TPO -0.55 -5.7 -0.3 2.72e-8 Placebo response in major depressive disorder (% change in symptom score); CRC cis rs9911578 0.967 rs3826353 chr17:57075299 C/T cg12560992 chr17:57184187 TRIM37 0.92 16.75 0.68 5.53e-46 Intelligence (multi-trait analysis); CRC cis rs734999 0.545 rs10910105 chr1:2538209 G/A cg20673091 chr1:2541236 MMEL1 0.37 5.91 0.31 8.45e-9 Ulcerative colitis; CRC cis rs736408 0.511 rs12637632 chr3:52708073 A/T cg18404041 chr3:52824283 ITIH1 -0.43 -8.83 -0.44 6.13e-17 Bipolar disorder; CRC cis rs3008870 0.583 rs2031495 chr1:67421714 G/T cg08660285 chr1:67390436 MIER1;WDR78 1.01 12.36 0.56 4.47e-29 Lymphocyte percentage of white cells; CRC cis rs4731207 0.596 rs10247349 chr7:124607495 C/T cg23710748 chr7:124431027 NA -0.43 -6.81 -0.35 4.56e-11 Cutaneous malignant melanoma; CRC cis rs17234274 0.644 rs7949855 chr11:23222449 C/T cg05245346 chr11:23248277 NA 0.35 5.75 0.3 2.02e-8 Cancer; CRC cis rs7781557 1.000 rs2041094 chr7:102495434 C/T cg18108683 chr7:102477205 FBXL13 -0.54 -6.86 -0.35 3.43e-11 Colorectal adenoma (advanced); CRC cis rs2032447 0.901 rs2213284 chr6:26031868 G/A cg03264133 chr6:25882463 NA -0.51 -6.94 -0.36 2.16e-11 Intelligence (multi-trait analysis); CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg26126750 chr3:195809198 TFRC 0.43 6.11 0.32 2.77e-9 Anxiety disorder; CRC cis rs10883723 0.810 rs2296582 chr10:104244139 G/T cg04362960 chr10:104952993 NT5C2 -0.43 -5.9 -0.31 8.86e-9 Allergic disease (asthma, hay fever or eczema); CRC cis rs35000415 0.745 rs117944677 chr7:128698185 A/T cg19972273 chr7:128594194 NA 0.71 6.15 0.32 2.2e-9 Systemic lupus erythematosus; CRC trans rs6951245 0.935 rs11766669 chr7:1063593 C/T cg13565492 chr6:43139072 SRF -0.69 -7.13 -0.37 6.32e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs25422 0.887 rs9320666 chr6:118989181 C/T cg15382696 chr6:118971807 C6orf204 0.47 6.51 0.34 2.88e-10 Renal cell carcinoma; CRC cis rs4555082 0.718 rs28513571 chr14:105709592 C/A cg06808227 chr14:105710500 BRF1 -0.63 -9.34 -0.46 1.51e-18 Mean platelet volume;Platelet distribution width; CRC cis rs2067615 0.524 rs10778504 chr12:107120424 C/T cg13491945 chr12:107078410 RFX4 0.36 6.23 0.32 1.42e-9 Heart rate; CRC cis rs1448094 0.549 rs57614821 chr12:86235361 A/C cg02569458 chr12:86230093 RASSF9 0.45 7.47 0.38 7.14e-13 Major depressive disorder; CRC cis rs1059312 0.966 rs7135968 chr12:129280066 G/A cg09035930 chr12:129282057 SLC15A4 0.54 9.06 0.45 1.19e-17 Systemic lupus erythematosus; CRC cis rs514406 0.505 rs269290 chr1:53167027 A/T cg24675658 chr1:53192096 ZYG11B -0.69 -10.7 -0.51 4.12e-23 Monocyte count; CRC cis rs4665809 0.941 rs41285975 chr2:26351144 T/C cg26119090 chr2:26468346 HADHA;HADHB -0.61 -7.88 -0.4 4.97e-14 Gut microbiome composition (summer); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg18642567 chr14:21755798 RPGRIP1 -0.42 -7.07 -0.36 9.05e-12 Liver disease severity in Alagille syndrome; CRC trans rs6598955 0.671 rs11247893 chr1:26597086 A/C cg07461501 chr17:79650226 HGS;ARL16 0.54 6.43 0.33 4.45e-10 Obesity-related traits; CRC cis rs9368481 0.569 rs6907403 chr6:26877297 A/C cg18278486 chr6:26987575 LOC100270746;C6orf41 0.39 6.06 0.32 3.76e-9 Autism spectrum disorder or schizophrenia; CRC cis rs13315871 1.000 rs13063504 chr3:58409854 A/G cg20936604 chr3:58311152 NA -0.75 -7.12 -0.37 6.99e-12 Cholesterol, total; CRC cis rs832540 0.830 rs252907 chr5:56120646 G/A cg12311346 chr5:56204834 C5orf35 -0.46 -7.04 -0.36 1.16e-11 Coronary artery disease; CRC cis rs8017423 0.586 rs2896134 chr14:90831293 G/A cg14092571 chr14:90743983 NA 0.38 5.8 0.3 1.6e-8 Mortality in heart failure; CRC cis rs10221833 0.602 rs355886 chr2:165634156 G/A cg03182029 chr2:165697222 COBLL1 0.48 5.66 0.3 3.26e-8 Response to statin therapy; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg04053862 chr2:179345017 MIR548N;PLEKHA3 0.42 5.99 0.31 5.53e-9 Intelligence (multi-trait analysis); CRC cis rs7811142 0.779 rs111312383 chr7:99905325 C/T cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.06 14.14 0.61 8.29e-36 Platelet count; CRC cis rs6952808 0.760 rs11764960 chr7:1950532 G/A cg02951883 chr7:2050386 MAD1L1 -0.69 -10.8 -0.51 1.81e-23 Bipolar disorder and schizophrenia; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg03398387 chr6:160114178 SOD2 0.45 6.29 0.33 9.86e-10 Response to antipsychotic treatment; CRC cis rs7737355 0.898 rs13164236 chr5:131079808 C/T cg06307176 chr5:131281290 NA 0.41 6.15 0.32 2.22e-9 Life satisfaction; CRC cis rs791888 0.858 rs1555434 chr10:89419143 G/C cg13926569 chr10:89418898 PAPSS2 -0.5 -7.31 -0.37 2.11e-12 Magnesium levels; CRC cis rs6860806 0.507 rs156322 chr5:131653925 C/T cg22638593 chr5:131593259 PDLIM4 0.36 5.76 0.3 1.89e-8 Breast cancer; CRC cis rs2075371 1.000 rs2598294 chr7:133991690 C/T cg20476274 chr7:133979776 SLC35B4 0.82 15.1 0.64 1.64e-39 Mean platelet volume; CRC cis rs9894429 0.646 rs9904137 chr17:79613925 C/T cg09655341 chr17:79618100 PDE6G -0.35 -6.03 -0.32 4.46e-9 Eye color traits; CRC cis rs13108904 0.935 rs6853002 chr4:1295991 C/T cg23123621 chr4:1343375 KIAA1530 0.32 5.69 0.3 2.84e-8 Obesity-related traits; CRC cis rs79387448 0.745 rs72993760 chr2:103151704 G/A cg09003973 chr2:102972529 NA 0.73 8.14 0.41 8.53e-15 Gut microbiota (bacterial taxa); CRC cis rs9858542 1.000 rs13316695 chr3:49684917 C/G cg07274523 chr3:49395745 GPX1 0.46 6.02 0.31 4.74e-9 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs75920871 0.528 rs10466590 chr11:116894413 C/G cg20608306 chr11:116969690 SIK3 -0.33 -6.4 -0.33 5.32e-10 Subjective well-being; CRC cis rs10979 0.597 rs9496687 chr6:143908815 A/G cg25407410 chr6:143891975 LOC285740 -0.67 -8.78 -0.44 9.1e-17 Hypospadias; CRC cis rs9787249 0.957 rs7547787 chr1:40220806 C/T cg19912559 chr1:40204330 PPIE 0.52 7.8 0.4 8.17e-14 Blood protein levels; CRC trans rs1455244 0.700 rs7229302 chr18:11508904 G/T cg17910969 chr17:73521755 LLGL2 0.44 6.77 0.35 5.9e-11 Schizophrenia; CRC cis rs453301 0.686 rs28665409 chr8:8869277 G/A cg20400248 chr8:9005257 PPP1R3B -0.37 -5.82 -0.31 1.4e-8 Joint mobility (Beighton score); CRC cis rs853679 0.550 rs1225598 chr6:28160799 T/G cg15786705 chr6:28176104 NA 0.81 11.69 0.54 1.25e-26 Depression; CRC cis rs4713118 0.662 rs149901 chr6:27965503 C/T cg03623178 chr6:28175578 NA 0.83 12.47 0.57 1.76e-29 Parkinson's disease; CRC cis rs17681684 0.565 rs12150149 chr17:9764039 A/C cg26853458 chr17:9805074 RCVRN -0.5 -9.04 -0.45 1.38e-17 GIP levels in response to oral glucose tolerance test (fasting); CRC cis rs6456156 0.742 rs3093026 chr6:167532690 A/G cg07741184 chr6:167504864 NA 0.33 5.94 0.31 7.32e-9 Primary biliary cholangitis; CRC cis rs6502050 0.835 rs4789737 chr17:80123269 G/A cg25804541 chr17:80189381 SLC16A3 -0.31 -5.95 -0.31 6.84e-9 Life satisfaction; CRC cis rs56235845 0.964 rs11746443 chr5:176798306 G/A cg25922969 chr5:176793941 RGS14 0.39 5.76 0.3 1.93e-8 Hemoglobin concentration;Hematocrit; CRC trans rs7613875 0.600 rs7061 chr3:50114515 C/T cg21665057 chr3:196295764 WDR53;FBXO45 -0.43 -6.27 -0.33 1.13e-9 Body mass index; CRC cis rs11997175 0.646 rs4593495 chr8:33692649 C/T ch.8.33884649F chr8:33765107 NA 0.46 6.68 0.35 1.01e-10 Body mass index; CRC cis rs7605827 0.930 rs3954894 chr2:15517656 T/C cg19274914 chr2:15703543 NA 0.38 5.66 0.3 3.29e-8 Educational attainment (years of education); CRC cis rs61160187 0.582 rs4642318 chr5:60292758 A/G cg16298547 chr5:60138761 ELOVL7 -0.27 -5.76 -0.3 1.95e-8 Educational attainment (years of education);Educational attainment (college completion); CRC cis rs2878628 0.650 rs56098033 chr3:52758571 T/A cg10802521 chr3:52805072 NEK4 -0.58 -9.14 -0.45 6.43e-18 Intelligence (multi-trait analysis); CRC cis rs807669 0.869 rs1061325 chr22:19184095 T/C cg02655711 chr22:19163373 SLC25A1 0.64 11.05 0.52 2.38e-24 Metabolite levels; CRC cis rs995000 0.899 rs1002687 chr1:62963737 G/A cg19896129 chr1:63156450 NA -0.39 -6.01 -0.31 4.99e-9 Triglyceride levels; CRC cis rs4665809 0.590 rs10495756 chr2:26485586 A/G cg27170947 chr2:26402098 FAM59B 0.6 7.82 0.4 7.45e-14 Gut microbiome composition (summer); CRC cis rs2386661 0.523 rs61832677 chr10:5652477 A/G cg26603656 chr10:5671107 NA 0.4 7.28 0.37 2.47e-12 Breast cancer; CRC trans rs10982213 0.830 rs2274163 chr9:117188714 C/T cg14780845 chr17:41323115 NBR1 0.38 6.0 0.31 5.31e-9 Interleukin-6 levels; CRC cis rs172166 0.637 rs1233708 chr6:28173219 C/T cg25164649 chr6:28176230 NA 0.61 8.85 0.44 5.43e-17 Cardiac Troponin-T levels; CRC cis rs67311347 0.868 rs10865895 chr3:40378677 C/T cg24209194 chr3:40518798 ZNF619 0.41 6.1 0.32 2.94e-9 Renal cell carcinoma; CRC cis rs9372498 0.764 rs9489369 chr6:118720704 A/C cg18833306 chr6:118973337 C6orf204 -0.5 -6.41 -0.33 5.15e-10 Diastolic blood pressure; CRC cis rs2762353 0.779 rs9393672 chr6:25842605 T/G cg12310025 chr6:25882481 NA -0.46 -6.97 -0.36 1.76e-11 Blood metabolite levels; CRC trans rs6545883 0.965 rs2305156 chr2:61729268 T/C cg11704114 chr12:21509398 SLCO1A2 -0.32 -6.19 -0.32 1.79e-9 Tuberculosis; CRC cis rs13392177 0.684 rs62185965 chr2:219073779 T/C cg04731861 chr2:219085781 ARPC2 0.32 6.5 0.34 2.93e-10 Pyoderma gangrenosum in inflammatory bowel disease; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg26964202 chr12:63328896 PPM1H 0.45 6.41 0.33 5.02e-10 Anxiety disorder; CRC cis rs736408 0.509 rs2590838 chr3:52622086 G/A cg18404041 chr3:52824283 ITIH1 -0.3 -6.28 -0.33 1.1e-9 Bipolar disorder; CRC trans rs6951245 0.938 rs11764937 chr7:1092074 C/T cg13565492 chr6:43139072 SRF -0.65 -6.68 -0.35 1.02e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs10028773 0.515 rs9994651 chr4:120587803 C/T cg09307838 chr4:120376055 NA 0.57 8.79 0.44 8.78e-17 Educational attainment; CRC cis rs66573146 0.831 rs66645969 chr4:6985614 G/A cg00086871 chr4:6988644 TBC1D14 1.02 8.54 0.43 4.99e-16 Granulocyte percentage of myeloid white cells; CRC cis rs35146811 0.695 rs1727132 chr7:99812297 T/C cg00553149 chr7:99775558 STAG3;GPC2 -0.24 -5.61 -0.3 4.38e-8 Coronary artery disease; CRC cis rs2072499 1.000 rs2241108 chr1:156181007 C/G cg06970220 chr1:156163860 SLC25A44 0.49 7.16 0.37 5.18e-12 Testicular germ cell tumor; CRC cis rs950169 0.922 rs12911223 chr15:84831671 G/A cg11189052 chr15:85197271 WDR73 -0.63 -8.95 -0.44 2.7e-17 Schizophrenia; CRC cis rs17270561 0.666 rs12209856 chr6:25793673 G/A cg17691542 chr6:26056736 HIST1H1C 0.62 7.93 0.4 3.57e-14 Iron status biomarkers; CRC cis rs10256972 0.758 rs2280724 chr7:1064720 A/G cg18402987 chr7:1209562 NA 0.43 6.32 0.33 8.37e-10 Longevity;Endometriosis; CRC cis rs6662572 1.000 rs7517111 chr1:46122140 A/G cg08644498 chr1:46502608 NA 0.48 7.04 0.36 1.13e-11 Blood protein levels; CRC cis rs1395 0.744 rs11126936 chr2:27483101 A/C cg14242246 chr2:27434262 C2orf28;SLC5A6 -0.31 -6.09 -0.32 3.15e-9 Blood metabolite levels; CRC cis rs9916302 0.861 rs11078912 chr17:37671490 A/G cg15445000 chr17:37608096 MED1 0.41 8.95 0.44 2.73e-17 Glomerular filtration rate (creatinine); CRC cis rs501120 0.564 rs2246891 chr10:44680591 A/G cg09554077 chr10:44749378 NA 0.5 6.98 0.36 1.62e-11 Coronary artery disease;Coronary heart disease; CRC cis rs12143943 0.966 rs4951410 chr1:204563817 G/A cg17419461 chr1:204415978 PIK3C2B 0.4 6.04 0.32 4.28e-9 Cognitive performance; CRC trans rs783540 0.656 rs783524 chr15:83284144 A/C cg18393722 chr15:85113863 UBE2QP1 -0.39 -6.13 -0.32 2.46e-9 Schizophrenia; CRC cis rs9309473 1.000 rs6755217 chr2:73641285 C/T cg20560298 chr2:73613845 ALMS1 -0.54 -6.27 -0.33 1.16e-9 Metabolite levels; CRC cis rs1448094 0.511 rs7139088 chr12:86147878 T/C cg19622623 chr12:86230825 RASSF9 0.4 6.15 0.32 2.22e-9 Major depressive disorder; CRC cis rs6951245 0.554 rs11544331 chr7:1131411 C/T cg03188948 chr7:1209495 NA 0.54 6.28 0.33 1.1e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC trans rs1814175 0.817 rs1818890 chr11:49856882 T/C cg15704280 chr7:45808275 SEPT13 -0.96 -18.34 -0.71 3.01e-52 Height; CRC cis rs6951245 0.580 rs78894484 chr7:1138721 T/G cg18297960 chr7:1142765 C7orf50 -0.43 -5.79 -0.3 1.66e-8 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs514406 0.505 rs835609 chr1:53170494 T/C cg08859206 chr1:53392774 SCP2 -0.39 -6.05 -0.32 3.96e-9 Monocyte count; CRC cis rs875971 0.862 rs6960446 chr7:65733259 A/G cg11764359 chr7:65958608 NA -0.58 -8.61 -0.43 3.09e-16 Aortic root size; CRC cis rs10489202 0.612 rs3820401 chr1:168074753 T/C cg24449463 chr1:168025552 DCAF6 -0.52 -7.55 -0.38 4.39e-13 Schizophrenia; CRC cis rs4731207 0.596 rs11763920 chr7:124640880 G/A cg23710748 chr7:124431027 NA -0.39 -6.25 -0.33 1.24e-9 Cutaneous malignant melanoma; CRC cis rs875971 0.862 rs13536 chr7:66019190 G/A cg18876405 chr7:65276391 NA -0.52 -8.38 -0.42 1.6e-15 Aortic root size; CRC cis rs28386778 1.000 rs3020613 chr17:61955983 A/G cg06873352 chr17:61820015 STRADA 0.75 14.08 0.61 1.43e-35 Prudent dietary pattern; CRC cis rs7666738 0.830 rs62318906 chr4:99037110 C/T cg05340658 chr4:99064831 C4orf37 0.61 9.43 0.46 7.65e-19 Colonoscopy-negative controls vs population controls; CRC cis rs853679 0.517 rs9380052 chr6:28064623 A/G cg02631126 chr6:28058918 ZSCAN12L1 0.28 5.67 0.3 3.18e-8 Depression; CRC cis rs6495122 0.501 rs6495144 chr15:75343438 T/C cg09165964 chr15:75287851 SCAMP5 -0.51 -7.82 -0.4 7.28e-14 Caffeine consumption;Diastolic blood pressure;Coffee consumption; CRC cis rs910316 0.935 rs2268620 chr14:75640403 G/A cg08847533 chr14:75593920 NEK9 -0.94 -17.43 -0.69 1.23e-48 Height; CRC cis rs9467160 0.871 rs9467168 chr6:24449036 A/G cg20631270 chr6:24437470 GPLD1 0.48 6.66 0.34 1.16e-10 Liver enzyme levels; CRC cis rs4653767 1.000 rs708774 chr1:226921530 C/G cg05049329 chr1:226924846 ITPKB 0.39 8.71 0.43 1.46e-16 Parkinson's disease; CRC cis rs2933343 1.000 rs1683811 chr3:128612113 A/C cg11901034 chr3:128598214 ACAD9 -0.5 -6.23 -0.32 1.44e-9 IgG glycosylation; CRC cis rs2282802 0.635 rs397463 chr5:139584275 C/G cg26211634 chr5:139558579 C5orf32 -0.45 -7.91 -0.4 3.99e-14 Intelligence (multi-trait analysis); CRC cis rs10504229 1.000 rs17816781 chr8:58186161 A/T cg02725872 chr8:58115012 NA -0.38 -6.43 -0.33 4.44e-10 Developmental language disorder (linguistic errors); CRC cis rs12580194 0.593 rs115471673 chr12:55766516 A/G cg19537932 chr12:55886519 OR6C68 -0.73 -9.2 -0.45 4.32e-18 Cancer; CRC cis rs881375 0.933 rs7859805 chr9:123664123 A/G cg09586646 chr9:123605570 PSMD5;LOC253039 0.53 7.17 0.37 5.01e-12 Rheumatoid arthritis; CRC trans rs7819412 0.775 rs2898257 chr8:10935368 A/C cg06636001 chr8:8085503 FLJ10661 -0.61 -9.06 -0.45 1.19e-17 Triglycerides; CRC cis rs1403694 0.695 rs11924390 chr3:186433099 T/C cg04611788 chr3:186434169 KNG1 -0.59 -8.81 -0.44 7.08e-17 Blood protein levels; CRC cis rs2180341 0.695 rs6569487 chr6:127726196 C/T cg24812749 chr6:127587940 RNF146 -0.58 -8.29 -0.42 2.84e-15 Breast cancer; CRC cis rs250677 0.687 rs250678 chr5:148434830 C/T cg23229984 chr5:148520753 ABLIM3 0.48 6.59 0.34 1.79e-10 Breast cancer; CRC cis rs4824093 0.610 rs9627799 chr22:50317989 C/T cg22709217 chr22:50311962 ALG12;CRELD2 -0.94 -8.7 -0.43 1.57e-16 Amyotrophic lateral sclerosis (sporadic); CRC cis rs4713118 0.662 rs149970 chr6:27980220 C/T cg21251018 chr6:28226885 NKAPL 0.49 7.16 0.37 5.42e-12 Parkinson's disease; CRC cis rs875971 0.964 rs6945032 chr7:65922486 C/T cg00343986 chr7:65444356 GUSB 0.43 6.29 0.33 1.03e-9 Aortic root size; CRC cis rs4290604 0.748 rs4549025 chr2:238052911 C/T cg23555395 chr2:238036564 NA 0.63 6.53 0.34 2.51e-10 Asthma; CRC cis rs3996993 0.809 rs72938170 chr6:52736385 C/T cg20803780 chr6:52668592 GSTA1 0.37 6.85 0.35 3.6e-11 Hemoglobin concentration; CRC cis rs7131987 0.903 rs1035604 chr12:29393102 G/A cg09582351 chr12:29534625 ERGIC2 -0.33 -6.92 -0.36 2.38e-11 QT interval; CRC cis rs9467773 1.000 rs10214634 chr6:26564582 T/A cg09904177 chr6:26538194 HMGN4 0.85 14.77 0.63 3.2e-38 Intelligence (multi-trait analysis); CRC cis rs13108904 0.870 rs13124876 chr4:1247955 T/C cg20092199 chr4:1342459 KIAA1530 0.34 5.95 0.31 6.85e-9 Obesity-related traits; CRC cis rs28386778 0.966 rs2008053 chr17:61954918 G/C cg25654072 chr17:61904446 PSMC5;FTSJ3 0.68 10.73 0.51 3.21e-23 Prudent dietary pattern; CRC cis rs611744 0.647 rs10106246 chr8:109268710 T/C cg18478394 chr8:109455254 TTC35 0.39 6.0 0.31 5.12e-9 Dupuytren's disease; CRC cis rs2739330 0.760 rs5760095 chr22:24247293 A/G cg16132339 chr22:24313637 DDTL;DDT 0.6 9.4 0.46 9.3e-19 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs1008375 0.932 rs10029173 chr4:17659598 C/T cg02297831 chr4:17616191 MED28 -0.47 -6.24 -0.33 1.33e-9 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs6912958 0.781 rs9450738 chr6:88267314 A/G cg12350822 chr6:88032061 C6orf162;GJB7 -0.33 -6.21 -0.32 1.6e-9 Monocyte percentage of white cells; CRC cis rs9487051 0.646 rs11153165 chr6:109622159 G/A cg01475377 chr6:109611718 NA -0.36 -5.65 -0.3 3.45e-8 Reticulocyte fraction of red cells; CRC trans rs10028773 0.632 rs34481394 chr4:120248374 C/T cg25214090 chr10:38739885 LOC399744 0.54 8.16 0.41 7.12e-15 Educational attainment; CRC cis rs12541335 0.639 rs4871994 chr8:22206038 G/A cg02463440 chr8:22132932 PIWIL2 0.51 8.74 0.43 1.23e-16 Hypertriglyceridemia; CRC cis rs9467711 0.659 rs66941101 chr6:26530376 C/T cg16898833 chr6:26189333 HIST1H4D 1.14 8.46 0.42 8.89e-16 Autism spectrum disorder or schizophrenia; CRC cis rs4689388 0.890 rs6446481 chr4:6295583 C/A cg14416269 chr4:6271139 WFS1 0.41 6.74 0.35 7.28e-11 Type 2 diabetes and other traits;Type 2 diabetes; CRC cis rs9910055 0.540 rs609292 chr17:42180436 G/A cg09913183 chr17:42254507 C17orf65;ASB16 -0.5 -6.88 -0.35 2.98e-11 Total body bone mineral density; CRC cis rs6963495 0.818 rs73192143 chr7:105202415 A/G cg13798780 chr7:105162888 PUS7 0.66 7.39 0.38 1.19e-12 Bipolar disorder (body mass index interaction); CRC cis rs2439831 0.867 rs2927072 chr15:43922398 T/C cg02155558 chr15:43621948 ADAL;LCMT2 0.67 7.51 0.38 5.67e-13 Lung cancer in ever smokers; CRC cis rs7998202 0.668 rs2774422 chr13:113352392 C/T cg02820901 chr13:113351484 ATP11A 0.64 7.02 0.36 1.3e-11 Glycated hemoglobin levels; CRC cis rs72717009 0.825 rs11810143 chr1:161480649 A/G cg23840854 chr1:161414152 NA -0.67 -7.85 -0.4 5.96e-14 Rheumatoid arthritis; CRC cis rs9303280 0.773 rs4795397 chr17:38023745 A/G cg00129232 chr17:37814104 STARD3 -0.45 -7.21 -0.37 3.98e-12 Self-reported allergy; CRC cis rs9910055 0.664 rs433610 chr17:42197281 A/G cg09913183 chr17:42254507 C17orf65;ASB16 -0.55 -7.86 -0.4 5.4e-14 Total body bone mineral density; CRC cis rs9372498 0.536 rs724868 chr6:118795152 C/T cg15382696 chr6:118971807 C6orf204 0.57 7.06 0.36 1.02e-11 Diastolic blood pressure; CRC cis rs7659604 0.539 rs11731917 chr4:122783233 G/A cg06713675 chr4:122721982 EXOSC9 -0.51 -8.29 -0.42 2.97e-15 Type 2 diabetes; CRC cis rs1577917 0.917 rs13213603 chr6:86534758 T/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.49 -6.58 -0.34 1.82e-10 Response to antipsychotic treatment; CRC trans rs2840044 1.000 rs11080357 chr17:33898933 G/A cg19694781 chr19:47549865 TMEM160 0.44 6.94 0.36 2.1e-11 Response to radiotherapy in cancer (late toxicity); CRC cis rs4970988 0.640 rs7524734 chr1:150655686 C/T cg18016565 chr1:150552671 MCL1 0.46 6.74 0.35 6.91e-11 Urate levels; CRC cis rs6570726 0.935 rs413916 chr6:145831400 T/C cg05347473 chr6:146136440 FBXO30 0.38 6.06 0.32 3.8e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs875971 1.000 rs1144894 chr7:65542894 A/G cg18876405 chr7:65276391 NA -0.52 -8.8 -0.44 7.65e-17 Aortic root size; CRC trans rs561341 0.830 rs7218801 chr17:30217778 A/G cg27661571 chr11:113659931 NA 0.62 7.33 0.37 1.75e-12 Hip circumference adjusted for BMI; CRC cis rs875971 0.862 rs7809814 chr7:65615397 G/A cg18876405 chr7:65276391 NA -0.51 -8.38 -0.42 1.55e-15 Aortic root size; CRC trans rs2547917 0.947 rs2702376 chr5:58707592 C/G cg15920655 chr2:129025795 HS6ST1 0.58 6.19 0.32 1.82e-9 Adverse response to chemotherapy (neutropenia/leucopenia) (gemcitabine); CRC cis rs7666738 0.830 rs13121558 chr4:99002848 G/A cg17366294 chr4:99064904 C4orf37 0.44 7.39 0.38 1.19e-12 Colonoscopy-negative controls vs population controls; CRC cis rs6860806 0.507 rs169256 chr5:131688533 A/G cg11843238 chr5:131593191 PDLIM4 0.42 6.16 0.32 2.13e-9 Breast cancer; CRC cis rs6570726 0.935 rs409121 chr6:145839793 G/A cg05347473 chr6:146136440 FBXO30 0.37 6.0 0.31 5.27e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs11971779 0.680 rs28579232 chr7:139073116 C/G cg07862535 chr7:139043722 LUC7L2 0.57 7.35 0.38 1.61e-12 Diisocyanate-induced asthma; CRC cis rs720844 1.000 rs4972383 chr2:149345062 G/A cg09247360 chr2:149335327 NA -0.62 -7.8 -0.39 8.45e-14 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs4975709 0.610 rs4975706 chr5:1860365 G/T cg15595755 chr5:1867978 NA 0.37 6.14 0.32 2.38e-9 Cardiovascular disease risk factors; CRC cis rs2032447 0.702 rs199753 chr6:26001888 G/A cg27635394 chr6:26043820 HIST1H2BB 0.46 6.56 0.34 2.14e-10 Intelligence (multi-trait analysis); CRC trans rs7762018 0.769 rs4716385 chr6:170127608 G/T cg06875740 chr19:51307921 C19orf48 -0.66 -6.03 -0.32 4.5e-9 Thiazide-induced adverse metabolic effects in hypertensive patients; CRC cis rs2836974 0.897 rs13049280 chr21:40594656 C/G cg11644478 chr21:40555479 PSMG1 0.71 10.14 0.49 3.35e-21 Cognitive function; CRC cis rs200986 1 rs200986 chr6:27824766 G/C cg26587870 chr6:27730563 NA -0.43 -6.69 -0.35 9.86e-11 Autism spectrum disorder or schizophrenia; CRC cis rs9640161 0.659 rs7806429 chr7:150013393 A/G cg13722127 chr7:150037890 RARRES2 0.47 7.94 0.4 3.32e-14 Blood protein levels;Circulating chemerin levels; CRC trans rs7937682 0.824 rs539524 chr11:111477325 A/G cg18187862 chr3:45730750 SACM1L 0.47 6.78 0.35 5.68e-11 Primary sclerosing cholangitis; CRC cis rs10911232 0.507 rs4652767 chr1:183002483 G/C ch.1.3577855R chr1:183094577 LAMC1 0.86 14.9 0.63 1.01e-38 Hypertriglyceridemia; CRC trans rs9929218 0.906 rs10852450 chr16:68749529 G/A cg04657470 chr2:198365150 HSPE1;HSPD1 -0.97 -14.39 -0.62 9.26e-37 Colorectal cancer; CRC cis rs9814567 0.896 rs2177602 chr3:134245866 A/G cg06109529 chr3:134205091 CEP63;ANAPC13 -0.81 -12.19 -0.56 1.92e-28 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs2303745 0.589 rs1864115 chr19:17393327 G/C cg04248312 chr19:17393744 ANKLE1 -0.93 -14.35 -0.62 1.31e-36 Systemic lupus erythematosus; CRC cis rs9303280 0.719 rs56750287 chr17:38062944 A/C cg00129232 chr17:37814104 STARD3 -0.49 -7.65 -0.39 2.22e-13 Self-reported allergy; CRC cis rs875971 1.000 rs778722 chr7:65844828 T/C cg11764359 chr7:65958608 NA 0.61 9.95 0.48 1.41e-20 Aortic root size; CRC cis rs5753037 0.547 rs140140 chr22:30166437 G/A cg01021169 chr22:30184971 ASCC2 -0.39 -5.94 -0.31 7.22e-9 Type 1 diabetes; CRC cis rs7493 0.755 rs13223537 chr7:94966167 C/T cg04155289 chr7:94953770 PON1 0.56 7.15 0.37 5.69e-12 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs2160860 0.773 rs10755980 chr8:39798322 C/G cg11363097 chr8:39792086 IDO2 -0.42 -7.24 -0.37 3.23e-12 Blood metabolite levels; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg00531750 chr3:66551802 LRIG1 0.43 6.12 0.32 2.7e-9 Intelligence (multi-trait analysis); CRC cis rs6141769 0.518 rs28378056 chr20:31298317 G/C cg13636640 chr20:31349939 DNMT3B -0.4 -6.14 -0.32 2.43e-9 Subjective well-being; CRC cis rs6743376 0.556 rs4849146 chr2:113824840 A/T cg09040174 chr2:113837401 NA 0.4 5.86 0.31 1.13e-8 Inflammatory biomarkers; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg03480535 chr4:87856849 AFF1 0.53 7.1 0.36 7.81e-12 Thyroid stimulating hormone; CRC cis rs889398 0.617 rs4985450 chr16:69901106 A/T cg00738113 chr16:70207722 CLEC18C 0.37 6.56 0.34 2.15e-10 Body mass index; CRC cis rs875971 1.000 rs1167612 chr7:65567976 C/A cg00343986 chr7:65444356 GUSB -0.45 -6.72 -0.35 8.03e-11 Aortic root size; CRC cis rs11229555 0.645 rs11229442 chr11:58196790 C/T cg15696309 chr11:58395628 NA -0.82 -10.31 -0.49 8.59e-22 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; CRC cis rs12682352 0.602 rs6993494 chr8:8667444 C/T cg06636001 chr8:8085503 FLJ10661 0.55 8.62 0.43 2.89e-16 Neuroticism; CRC cis rs6496667 0.514 rs62019353 chr15:90933683 T/C cg22089800 chr15:90895588 ZNF774 0.47 5.93 0.31 7.56e-9 Rheumatoid arthritis; CRC cis rs8031584 0.678 rs8035703 chr15:31168472 T/C cg08704250 chr15:31115839 NA -0.56 -9.87 -0.48 2.65e-20 Huntington's disease progression; CRC cis rs10791097 0.694 rs2155751 chr11:130755240 G/A cg12179176 chr11:130786555 SNX19 0.75 12.57 0.57 7.16e-30 Autism spectrum disorder or schizophrenia;Schizophrenia; CRC cis rs62064224 0.530 rs8073708 chr17:30680493 T/C cg25809561 chr17:30822961 MYO1D 0.52 9.2 0.45 4.24e-18 Schizophrenia; CRC cis rs3785574 0.962 rs2584621 chr17:61912436 G/A cg25654072 chr17:61904446 PSMC5;FTSJ3 0.44 6.01 0.31 4.93e-9 Height; CRC cis rs1448094 0.802 rs7487591 chr12:86434112 T/C cg18827107 chr12:86230957 RASSF9 -0.36 -5.67 -0.3 3.05e-8 Major depressive disorder; CRC cis rs2732480 0.523 rs34286639 chr12:48629044 C/T cg24011408 chr12:48396354 COL2A1 0.46 6.35 0.33 7.23e-10 Hemoglobin concentration;Red blood cell count;Hematocrit; CRC cis rs17826219 0.706 rs55764512 chr17:29085758 G/A cg13385521 chr17:29058706 SUZ12P 0.73 8.33 0.42 2.14e-15 Body mass index; CRC trans rs3942852 0.774 rs2270990 chr11:48184983 G/T cg15704280 chr7:45808275 SEPT13 -0.75 -9.35 -0.46 1.43e-18 Acute lymphoblastic leukemia (childhood); CRC cis rs11758351 1.000 rs1341759 chr6:26195502 G/A cg01420254 chr6:26195488 NA 0.83 8.68 0.43 1.82e-16 Gout;Renal underexcretion gout; CRC cis rs17023223 0.537 rs12083510 chr1:119746620 T/G cg05756136 chr1:119680316 WARS2 -0.52 -7.03 -0.36 1.19e-11 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for BMI in active individuals; CRC cis rs1552244 0.766 rs34232505 chr3:10186216 T/A cg18598329 chr3:10140678 FANCD2;C3orf24 -0.81 -10.46 -0.5 2.59e-22 Alzheimer's disease; CRC cis rs477895 0.713 rs3802933 chr11:63988102 C/T cg04317338 chr11:64019027 PLCB3 0.61 7.55 0.38 4.37e-13 Mean platelet volume; CRC cis rs526821 0.595 rs2926309 chr11:55314219 G/A cg04317927 chr11:55418816 OR4S2 0.38 6.49 0.34 3.24e-10 Pediatric bone mineral density (spine); CRC cis rs6089584 0.888 rs2892060 chr20:60617955 G/T cg13770153 chr20:60521292 NA -0.58 -8.81 -0.44 7.37e-17 Body mass index; CRC cis rs834811 0.863 rs834821 chr7:135895713 A/T cg01726295 chr7:135938950 NA 0.4 6.92 0.36 2.31e-11 Post-traumatic stress disorder; CRC cis rs597539 0.652 rs627731 chr11:68698663 A/C cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.86 14.36 0.62 1.24e-36 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC trans rs7395662 0.553 rs4882155 chr11:48705801 T/C cg21153622 chr11:89784906 NA -0.52 -8.77 -0.44 9.87e-17 HDL cholesterol; CRC cis rs4689592 0.546 rs10937782 chr4:7057106 G/C cg26116260 chr4:7069785 GRPEL1 0.94 14.42 0.62 6.86e-37 Monocyte percentage of white cells; CRC cis rs7737355 0.842 rs7731001 chr5:130781338 T/C cg25547332 chr5:131281432 NA -0.36 -5.74 -0.3 2.11e-8 Life satisfaction; CRC cis rs4780355 0.918 rs243318 chr16:11358018 G/A cg00044050 chr16:11439710 C16orf75 0.42 5.97 0.31 6.09e-9 Crohn's disease and psoriasis; CRC cis rs12701220 0.894 rs13224488 chr7:1052353 C/A cg26769984 chr7:1090371 C7orf50 0.69 9.16 0.45 5.52e-18 Bronchopulmonary dysplasia; CRC cis rs2354432 0.607 rs11587707 chr1:146707186 T/C cg25205988 chr1:146714368 CHD1L -1.16 -9.44 -0.46 7.24e-19 Mitochondrial DNA levels; CRC trans rs67073037 0.955 rs12465258 chr2:29162904 G/T cg13899017 chr1:159158444 CADM3 -0.37 -6.14 -0.32 2.4e-9 Breast cancer;Breast cancer (estrogen-receptor negative); CRC trans rs9914544 0.505 rs7503678 chr17:18776020 A/T cg21372672 chr17:16614065 CCDC144A -0.38 -6.02 -0.31 4.6e-9 Educational attainment (years of education); CRC cis rs7212590 0.748 rs73315252 chr17:57854855 A/G cg10252138 chr17:58120427 NA -0.55 -5.87 -0.31 1.09e-8 Granulocyte percentage of myeloid white cells;Monocyte count;Monocyte percentage of white cells; CRC cis rs897984 0.683 rs9932572 chr16:30841642 A/G cg02466173 chr16:30829666 NA -0.87 -16.16 -0.67 1.17e-43 Dementia with Lewy bodies; CRC cis rs72945132 0.714 rs117232799 chr11:70157182 G/A cg00319359 chr11:70116639 PPFIA1 0.71 6.65 0.34 1.23e-10 Coronary artery disease; CRC cis rs743757 1.000 rs2236955 chr3:50429876 G/A cg09545109 chr3:50388910 TUSC4;CYB561D2 0.44 5.84 0.31 1.24e-8 Diastolic blood pressure; CRC cis rs2836974 0.932 rs2234543 chr21:40572072 G/A cg11890956 chr21:40555474 PSMG1 1.09 18.67 0.72 1.44e-53 Cognitive function; CRC cis rs6951245 1.000 rs76833820 chr7:1070278 A/T cg21664854 chr7:1097933 C7orf50;GPR146 0.79 8.92 0.44 3.39e-17 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs950027 0.620 rs1145093 chr15:45649813 C/A cg10760299 chr15:45669010 GATM 0.35 5.62 0.3 4.17e-8 Response to fenofibrate (adiponectin levels); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg21789229 chr4:54232186 SCFD2 0.39 6.23 0.32 1.42e-9 Liver disease severity in Alagille syndrome; CRC cis rs8141529 0.843 rs1065497 chr22:29279991 C/T cg02153584 chr22:29168773 CCDC117 0.41 5.62 0.3 4.12e-8 Lymphocyte counts; CRC cis rs7666738 0.830 rs1120708 chr4:98931260 G/C cg17366294 chr4:99064904 C4orf37 0.43 7.32 0.37 1.95e-12 Colonoscopy-negative controls vs population controls; CRC cis rs17023223 0.537 rs2645302 chr1:119590398 A/C cg05756136 chr1:119680316 WARS2 -0.46 -6.21 -0.32 1.61e-9 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for BMI in active individuals; CRC cis rs9303401 0.659 rs35564417 chr17:56718286 G/T cg02118635 chr17:56770003 RAD51C;TEX14 0.79 9.9 0.48 2.16e-20 Cognitive test performance; CRC cis rs2976388 0.609 rs2572909 chr8:143806464 C/G cg04969067 chr8:143858791 LYNX1 0.44 7.47 0.38 7.38e-13 Urinary tract infection frequency; CRC cis rs7927592 0.956 rs10896337 chr11:68284236 T/C cg01657329 chr11:68192670 LRP5 -0.47 -6.87 -0.35 3.29e-11 Total body bone mineral density; CRC cis rs10504229 0.728 rs72650861 chr8:58153273 T/C cg08219700 chr8:58056026 NA 0.45 5.74 0.3 2.11e-8 Developmental language disorder (linguistic errors); CRC cis rs738321 0.694 rs4821749 chr22:38542074 A/G cg25457927 chr22:38595422 NA -0.3 -5.98 -0.31 5.92e-9 Breast cancer; CRC trans rs3942852 0.806 rs10734562 chr11:48128189 A/T cg03929089 chr4:120376271 NA 0.57 7.16 0.37 5.41e-12 Acute lymphoblastic leukemia (childhood); CRC cis rs2549003 0.966 rs2706386 chr5:131832687 C/T cg00255919 chr5:131827918 IRF1 -0.6 -11.93 -0.55 1.7e-27 Asthma (sex interaction); CRC cis rs1107366 1.000 rs9874508 chr3:125902417 A/G cg21601837 chr3:125900065 ALDH1L1 0.35 5.77 0.3 1.86e-8 Metabolite levels; CRC cis rs728616 0.558 rs12772945 chr10:82154496 C/T cg11900509 chr10:81946545 ANXA11 -0.56 -6.24 -0.33 1.32e-9 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs11696845 0.626 rs6073537 chr20:43378270 A/G cg25301532 chr20:43378953 KCNK15 -0.38 -6.81 -0.35 4.75e-11 Obesity-related traits; CRC cis rs938554 0.612 rs7669607 chr4:9997801 C/T cg00071950 chr4:10020882 SLC2A9 -0.47 -6.44 -0.33 4.29e-10 Blood metabolite levels; CRC cis rs1448094 0.556 rs11611968 chr12:86168022 G/A cg25456477 chr12:86230367 RASSF9 0.4 6.76 0.35 6.23e-11 Major depressive disorder; CRC trans rs1814175 0.586 rs10769603 chr11:49688837 T/C cg03929089 chr4:120376271 NA -0.84 -13.81 -0.61 1.5e-34 Height; CRC cis rs9354308 0.834 rs12212376 chr6:66598879 T/C cg07460842 chr6:66804631 NA 0.45 5.68 0.3 3e-8 Metabolite levels; CRC cis rs1499614 1.000 rs2707832 chr7:66136549 C/T cg25985355 chr7:65971099 NA -0.5 -5.87 -0.31 1.04e-8 Gout; CRC cis rs4713118 0.513 rs149897 chr6:28006650 A/G cg10876282 chr6:28092338 ZSCAN16 0.47 6.41 0.33 5.18e-10 Parkinson's disease; CRC cis rs3749237 1.000 rs6804655 chr3:49738945 C/T cg03060546 chr3:49711283 APEH 0.52 7.76 0.39 1.11e-13 Resting heart rate; CRC cis rs4853012 0.838 rs12619982 chr2:74356022 G/A cg05890377 chr2:74357713 NA 0.66 10.35 0.5 6.58e-22 Gestational age at birth (maternal effect); CRC cis rs9303280 0.806 rs9909593 chr17:37970149 C/T cg00129232 chr17:37814104 STARD3 0.46 7.44 0.38 8.92e-13 Self-reported allergy; CRC trans rs8073060 0.586 rs9303690 chr17:34005513 C/T cg19694781 chr19:47549865 TMEM160 -1.1 -15.25 -0.64 4.44e-40 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; CRC cis rs2836974 0.931 rs2776307 chr21:40713833 C/G cg06238570 chr21:40685208 BRWD1 -0.67 -9.01 -0.44 1.76e-17 Cognitive function; CRC cis rs2795502 0.630 rs2282443 chr10:43474169 A/G cg08461752 chr10:43522343 NA -0.85 -7.59 -0.39 3.41e-13 Blood protein levels; CRC cis rs6088590 0.735 rs6088618 chr20:33409350 G/A cg24642439 chr20:33292090 TP53INP2 0.46 8.08 0.41 1.23e-14 Coronary artery disease; CRC cis rs116161686 0.500 rs55871867 chr1:210051029 A/G cg22029157 chr1:209979665 IRF6 0.59 6.94 0.36 2.1e-11 Coronary artery disease; CRC cis rs2227564 0.597 rs2271271 chr10:75558867 G/A cg00564723 chr10:75632066 CAMK2G -0.31 -7.56 -0.38 4.02e-13 Crohn's disease;Inflammatory bowel disease; CRC cis rs6912958 0.712 rs2754262 chr6:88405585 A/G cg12350822 chr6:88032061 C6orf162;GJB7 -0.32 -6.05 -0.32 4.04e-9 Monocyte percentage of white cells; CRC cis rs10206020 0.885 rs6720923 chr2:1574197 T/C cg26248373 chr2:1572462 NA -0.83 -12.5 -0.57 1.34e-29 IgG glycosylation; CRC cis rs2243480 1.000 rs56016656 chr7:65383481 C/T cg25985355 chr7:65971099 NA -0.5 -5.79 -0.3 1.67e-8 Diabetic kidney disease; CRC trans rs7615952 0.673 rs115942855 chr3:125601960 G/A cg07211511 chr3:129823064 LOC729375 -1.09 -11.5 -0.54 6.13e-26 Blood pressure (smoking interaction); CRC cis rs847577 0.832 rs1799068 chr7:97707069 G/T cg24562669 chr7:97807699 LMTK2 -0.64 -11.97 -0.55 1.23e-27 Breast cancer; CRC cis rs1707322 0.721 rs6429575 chr1:46134216 G/C cg06784218 chr1:46089804 CCDC17 0.66 12.35 0.56 4.77e-29 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs427941 0.655 rs2529095 chr7:101749663 C/T cg06246474 chr7:101738831 CUX1 0.44 6.72 0.35 8.09e-11 Plasma omega-3 polyunsaturated fatty acid level (eicosapentaenoic acid); CRC cis rs699 0.698 rs2478527 chr1:230863398 A/C cg07502417 chr1:230849801 AGT 0.29 5.94 0.31 7.11e-9 Coronary artery disease; CRC cis rs6952808 0.691 rs2398709 chr7:2112548 C/T cg04267008 chr7:1944627 MAD1L1 -0.72 -9.92 -0.48 1.82e-20 Bipolar disorder and schizophrenia; CRC cis rs12410462 0.681 rs4131980 chr1:227572123 A/G cg04117972 chr1:227635322 NA 0.65 6.07 0.32 3.57e-9 Major depressive disorder; CRC cis rs11098499 1.000 rs13116504 chr4:120209412 A/C cg24375607 chr4:120327624 NA 0.43 6.64 0.34 1.28e-10 Corneal astigmatism; CRC cis rs853679 0.550 rs1225599 chr6:28165190 C/T cg15845792 chr6:28175446 NA 1.02 15.66 0.65 1.12e-41 Depression; CRC trans rs2243480 1.000 rs1715235 chr7:65488394 T/C cg10756647 chr7:56101905 PSPH 0.77 8.22 0.41 4.72e-15 Diabetic kidney disease; CRC cis rs9322193 0.923 rs10782314 chr6:150056663 C/T cg13206674 chr6:150067644 NUP43 0.67 9.79 0.48 4.89e-20 Lung cancer; CRC cis rs6860806 0.661 rs1588263 chr5:131577158 T/C cg22638593 chr5:131593259 PDLIM4 0.42 7.8 0.4 8.11e-14 Breast cancer; CRC cis rs877282 1.000 rs2004479 chr10:770854 G/A cg17470449 chr10:769945 NA 0.63 8.98 0.44 2.18e-17 Uric acid levels; CRC cis rs2769264 0.546 rs12071705 chr1:151430504 G/C cg18801370 chr1:151430492 POGZ 0.59 6.86 0.35 3.34e-11 Blood trace element (Cu levels); CRC cis rs4713118 0.955 rs9393847 chr6:27687973 G/A cg03623178 chr6:28175578 NA 0.64 8.51 0.42 6.36e-16 Parkinson's disease; CRC cis rs514406 0.644 rs6662414 chr1:53198893 A/G cg08859206 chr1:53392774 SCP2 0.42 6.56 0.34 2.14e-10 Monocyte count; CRC cis rs4727027 0.933 rs12532104 chr7:148864233 A/C cg12479418 chr7:148823350 ZNF425;ZNF398 0.42 5.76 0.3 1.91e-8 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC cis rs7705042 0.686 rs62381975 chr5:141513018 G/A cg07392085 chr5:141489673 NDFIP1 -0.41 -5.96 -0.31 6.36e-9 Asthma; CRC trans rs12257178 0.532 rs12263857 chr10:113006704 A/G cg02683314 chr19:4182606 SIRT6;ANKRD24 -0.47 -6.73 -0.35 7.52e-11 Longitudinal alcohol consumption; CRC cis rs7394190 0.748 rs4082339 chr10:75539812 C/T cg07699608 chr10:75541558 CHCHD1 -0.64 -6.71 -0.35 8.65e-11 Incident atrial fibrillation; CRC cis rs6701037 0.566 rs4344281 chr1:175135376 C/T cg14847009 chr1:175162515 KIAA0040 0.29 6.46 0.34 3.67e-10 Alcohol dependence; CRC trans rs7618501 0.573 rs2624824 chr3:50088266 T/C cg21665057 chr3:196295764 WDR53;FBXO45 -0.56 -8.89 -0.44 4.07e-17 Intelligence (multi-trait analysis); CRC trans rs800082 0.531 rs2204603 chr3:144258720 T/A cg24215973 chr2:240111563 HDAC4 0.44 6.19 0.32 1.82e-9 Smoking behavior; CRC cis rs875971 0.862 rs1983372 chr7:65611351 C/T cg18876405 chr7:65276391 NA -0.52 -8.61 -0.43 3.1e-16 Aortic root size; CRC trans rs11098499 0.691 rs12502524 chr4:120271414 G/A cg25214090 chr10:38739885 LOC399744 0.53 8.51 0.42 6.28e-16 Corneal astigmatism; CRC cis rs12586317 0.620 rs17103042 chr14:35575428 T/C cg05294307 chr14:35346193 BAZ1A -0.67 -7.69 -0.39 1.77e-13 Psoriasis; CRC cis rs8038465 0.622 rs62004587 chr15:73859016 A/C cg15420318 chr15:73925796 NPTN 0.43 6.79 0.35 5.35e-11 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs3823572 0.526 rs2971967 chr7:133642595 A/G cg03336402 chr7:133662267 EXOC4 -0.68 -10.48 -0.5 2.23e-22 Intelligence (multi-trait analysis); CRC cis rs896854 0.684 rs2340534 chr8:95992330 G/A cg13393036 chr8:95962371 TP53INP1 -0.51 -8.71 -0.43 1.55e-16 Type 2 diabetes; CRC cis rs274567 0.501 rs581968 chr5:131710202 G/A cg22638593 chr5:131593259 PDLIM4 -0.38 -6.32 -0.33 8.61e-10 Blood metabolite levels; CRC cis rs3790844 0.876 rs3790847 chr1:200006217 G/T cg13229857 chr1:200006247 NR5A2 0.54 7.6 0.39 3.04e-13 Pancreatic cancer; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg01920373 chr16:66968627 FAM96B;CES2 0.41 6.2 0.32 1.7e-9 Intelligence (multi-trait analysis); CRC cis rs2290405 0.593 rs12499663 chr4:888170 G/A cg20916646 chr4:852691 GAK 0.4 5.92 0.31 8.25e-9 Systemic sclerosis; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg25504222 chr19:4639508 TNFAIP8L1 0.43 6.29 0.33 1.03e-9 Response to antipsychotic treatment; CRC cis rs9486719 1.000 rs12193732 chr6:96942609 G/A cg06623918 chr6:96969491 KIAA0776 -0.79 -9.12 -0.45 7.75e-18 Migraine;Coronary artery disease; CRC cis rs4332037 0.510 rs11764040 chr7:1884830 G/C cg24505167 chr7:1915268 MAD1L1 -0.34 -5.6 -0.3 4.45e-8 Bipolar disorder; CRC cis rs1355223 0.583 rs2941058 chr11:34880245 C/G cg24088639 chr11:34937564 PDHX;APIP -0.54 -7.78 -0.39 9.55e-14 Systemic lupus erythematosus and Systemic sclerosis; CRC cis rs427941 0.703 rs201452 chr7:101739663 C/T cg06246474 chr7:101738831 CUX1 0.46 7.23 0.37 3.35e-12 Plasma omega-3 polyunsaturated fatty acid level (eicosapentaenoic acid); CRC cis rs6840360 1.000 rs6535819 chr4:152651503 A/G cg09659197 chr4:152720779 NA 0.52 11.28 0.53 3.6e-25 Intelligence (multi-trait analysis); CRC cis rs798554 0.679 rs1636253 chr7:2885123 A/G cg19346786 chr7:2764209 NA -0.38 -6.53 -0.34 2.54e-10 Height; CRC cis rs8177253 0.574 rs6775042 chr3:133442245 G/T cg11941060 chr3:133502564 NA -0.41 -6.79 -0.35 5.25e-11 Iron status biomarkers; CRC cis rs9733 0.519 rs11204717 chr1:150709129 T/A cg10589385 chr1:150898437 SETDB1 0.29 6.13 0.32 2.47e-9 Tonsillectomy; CRC cis rs1568889 0.592 rs17652117 chr11:28483645 C/T cg06544937 chr11:28130018 METT5D1;KIF18A -0.61 -7.13 -0.37 6.51e-12 Bipolar disorder; CRC cis rs12541635 0.902 rs59123253 chr8:107006365 C/T cg10147462 chr8:107024639 NA 0.42 6.94 0.36 2.09e-11 Age of smoking initiation; CRC cis rs637571 0.522 rs28578718 chr11:65748400 C/A cg02427764 chr11:65769310 BANF1;EIF1AD 0.4 5.77 0.3 1.79e-8 Eosinophil percentage of white cells; CRC cis rs9858542 0.953 rs7648841 chr3:49416825 G/A cg07274523 chr3:49395745 GPX1 0.46 6.23 0.32 1.46e-9 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs12497850 0.897 rs9681717 chr3:48872998 A/G cg20833759 chr3:49053208 WDR6;DALRD3 0.53 9.04 0.45 1.36e-17 Parkinson's disease; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg23387220 chr4:53578496 SNORA26;KIAA0114 0.42 6.35 0.33 7.05e-10 Liver disease severity in Alagille syndrome; CRC cis rs2075371 0.611 rs13235296 chr7:134019192 A/G cg20476274 chr7:133979776 SLC35B4 -0.52 -7.71 -0.39 1.52e-13 Mean platelet volume; CRC cis rs1799949 0.965 rs6503727 chr17:41312859 C/T cg23758822 chr17:41437982 NA 0.92 18.8 0.72 4.57e-54 Menopause (age at onset); CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg24689099 chr15:66084495 DENND4A 0.46 6.29 0.33 1.02e-9 Anxiety disorder; CRC cis rs2019137 0.560 rs6707386 chr2:113981022 G/A cg07594247 chr2:113993304 PAX8;LOC440839;LOC654433 0.5 7.58 0.39 3.5e-13 Lymphocyte counts; CRC cis rs875971 0.545 rs67397473 chr7:65633305 A/G cg11764359 chr7:65958608 NA 0.47 6.13 0.32 2.47e-9 Aortic root size; CRC cis rs7412746 0.658 rs10305711 chr1:150802996 T/C cg17724175 chr1:150552817 MCL1 0.49 7.34 0.38 1.7e-12 Melanoma; CRC cis rs12410462 0.502 rs77615958 chr1:227806083 T/C cg23173402 chr1:227635558 NA 0.69 5.78 0.3 1.78e-8 Major depressive disorder; CRC cis rs6062302 0.522 rs2297427 chr20:62221364 G/A cg09650180 chr20:62225654 GMEB2 -0.5 -6.7 -0.35 9.27e-11 Glioblastoma; CRC cis rs2120019 0.938 rs8033925 chr15:75311959 A/G cg09165964 chr15:75287851 SCAMP5 -0.86 -13.46 -0.6 3.28e-33 Blood trace element (Zn levels); CRC cis rs17001868 0.568 rs9611311 chr22:40733951 T/C cg07138101 chr22:40742427 ADSL 0.59 7.86 0.4 5.36e-14 Mammographic density (dense area); CRC cis rs2976388 0.647 rs2585136 chr8:143812141 A/G cg22687807 chr8:143858763 LYNX1 0.52 9.2 0.45 4.34e-18 Urinary tract infection frequency; CRC trans rs17126268 0.502 rs1340395 chr1:102890127 C/T cg18468354 chr14:36993517 NA 0.38 6.12 0.32 2.65e-9 Glomerular filtration rate; CRC cis rs6743376 0.509 rs3180234 chr2:113820655 A/T cg09040174 chr2:113837401 NA 0.4 5.84 0.31 1.22e-8 Inflammatory biomarkers; CRC cis rs76878669 0.561 rs4930177 chr11:66120784 T/C cg18002602 chr11:66138449 SLC29A2 0.28 6.14 0.32 2.43e-9 Educational attainment (years of education); CRC cis rs4742903 0.967 rs10820605 chr9:106881402 C/T cg21169611 chr9:106856078 SMC2 0.4 5.66 0.3 3.22e-8 High-grade serous ovarian cancer;Breast cancer; CRC cis rs2153535 0.560 rs2210798 chr6:8481522 C/T cg07606381 chr6:8435919 SLC35B3 0.68 10.89 0.51 8.84e-24 Motion sickness; CRC cis rs2836974 0.831 rs34294410 chr21:40555160 C/G cg11890956 chr21:40555474 PSMG1 1.09 18.57 0.72 3.71e-53 Cognitive function; CRC cis rs6879260 0.963 rs1035412 chr5:179729328 C/T cg23248424 chr5:179741104 GFPT2 -0.64 -9.88 -0.48 2.57e-20 Height; CRC cis rs832540 0.552 rs252924 chr5:56205643 A/G cg18230493 chr5:56204884 C5orf35 -0.46 -6.69 -0.35 9.61e-11 Coronary artery disease; CRC cis rs6502050 0.835 rs9901076 chr17:80170020 G/A cg19223190 chr17:80058835 NA 0.42 6.77 0.35 5.88e-11 Life satisfaction; CRC trans rs11165623 0.765 rs11807955 chr1:96891623 C/T cg10631902 chr5:14652156 NA -0.5 -9.44 -0.46 7.1e-19 Hip circumference;Waist circumference; CRC cis rs72848980 0.512 rs12359556 chr10:105390677 C/T cg00126946 chr10:105363258 SH3PXD2A 0.5 6.33 0.33 7.93e-10 White matter hyperintensity burden; CRC cis rs1005277 0.579 rs2474594 chr10:38426661 G/C cg25427524 chr10:38739819 LOC399744 -0.77 -13.58 -0.6 1.19e-33 Extrinsic epigenetic age acceleration; CRC cis rs910316 0.763 rs2080201 chr14:75629972 C/T cg11812906 chr14:75593930 NEK9 -0.56 -8.54 -0.43 4.98e-16 Height; CRC cis rs10242455 0.702 rs78218664 chr7:99154381 C/A cg18809830 chr7:99032528 PTCD1 -1.32 -9.14 -0.45 6.74e-18 Blood metabolite levels; CRC cis rs709400 1.000 rs10135248 chr14:104122310 T/C cg24130564 chr14:104152367 KLC1 -0.47 -7.16 -0.37 5.18e-12 Body mass index; CRC cis rs798554 0.759 rs798495 chr7:2797267 T/C cg13628971 chr7:2884303 GNA12 0.53 7.16 0.37 5.37e-12 Height; CRC cis rs7666738 0.830 rs2114426 chr4:98933130 C/T cg05340658 chr4:99064831 C4orf37 0.6 9.35 0.46 1.41e-18 Colonoscopy-negative controls vs population controls; CRC cis rs6496667 0.865 rs12594934 chr15:90887750 G/T cg04176472 chr15:90893244 GABARAPL3 0.58 6.84 0.35 3.94e-11 Rheumatoid arthritis; CRC cis rs10463316 0.894 rs7709994 chr5:150753597 A/T cg03212797 chr5:150827313 SLC36A1 -0.54 -8.57 -0.43 4.1e-16 Metabolite levels (Pyroglutamine); CRC cis rs3820928 0.904 rs2217359 chr2:227759892 C/T cg11843606 chr2:227700838 RHBDD1 -0.39 -5.68 -0.3 2.92e-8 Pulmonary function; CRC cis rs2857891 1.000 rs1388527 chr11:6948441 C/T cg12728517 chr11:6947552 ZNF215 0.57 6.14 0.32 2.38e-9 Response to cytadine analogues (cytosine arabinoside); CRC cis rs10504229 0.683 rs2318148 chr8:58114955 G/A cg24829409 chr8:58192753 C8orf71 -0.54 -7.94 -0.4 3.33e-14 Developmental language disorder (linguistic errors); CRC cis rs643506 1.000 rs4936675 chr11:111623088 T/A cg09085632 chr11:111637200 PPP2R1B 0.5 6.51 0.34 2.88e-10 Breast cancer; CRC cis rs4713118 0.540 rs469227 chr6:27970705 A/C cg12273811 chr6:28175739 NA 0.6 8.82 0.44 7e-17 Parkinson's disease; CRC cis rs7020830 0.867 rs55845273 chr9:37362219 C/T cg14294708 chr9:37120828 ZCCHC7 1.19 27.0 0.83 1.83e-85 Schizophrenia; CRC cis rs12701220 0.895 rs12534778 chr7:1065861 C/T cg00990874 chr7:1149470 C7orf50 0.58 6.64 0.34 1.29e-10 Bronchopulmonary dysplasia; CRC cis rs7909074 1.000 rs10751361 chr10:45398186 C/A cg04218760 chr10:45406644 TMEM72 -0.34 -9.55 -0.47 3.04e-19 Mean corpuscular volume; CRC cis rs4660214 0.724 rs11205695 chr1:39620957 A/C cg11070191 chr1:39582205 MACF1 0.35 5.69 0.3 2.82e-8 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs1728785 1.000 rs1170434 chr16:68606590 A/G cg02972257 chr16:68554789 NA -0.66 -7.89 -0.4 4.55e-14 Ulcerative colitis; CRC cis rs4237845 0.611 rs10877036 chr12:58321650 A/G cg02175503 chr12:58329896 NA -0.78 -12.85 -0.58 6.42e-31 Intelligence (multi-trait analysis); CRC cis rs2415984 0.538 rs4595715 chr14:46967541 C/T cg14871534 chr14:47121158 RPL10L -0.43 -6.26 -0.33 1.21e-9 Number of children ever born; CRC trans rs35110281 0.782 rs9981790 chr21:45045052 G/C cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.42 6.73 0.35 7.5e-11 Mean corpuscular volume; CRC trans rs7546 0.504 rs2075636 chr16:4938321 A/T cg19252218 chr17:41477271 ARL4D -0.44 -6.52 -0.34 2.71e-10 Cancer; CRC cis rs9916302 0.861 rs644173 chr17:37430519 T/C cg03013999 chr17:37608204 MED1 0.48 7.33 0.37 1.79e-12 Glomerular filtration rate (creatinine); CRC cis rs375066 0.623 rs2217669 chr19:44353080 T/C cg19542119 chr19:44331823 ZNF283 0.4 5.61 0.3 4.24e-8 Breast cancer; CRC cis rs1003719 0.715 rs7282195 chr21:38508619 C/T cg10648535 chr21:38446584 PIGP;TTC3 -0.48 -6.65 -0.34 1.23e-10 Eye color traits; CRC cis rs908922 0.676 rs569032 chr1:152508615 C/T cg23254163 chr1:152506842 NA 0.47 9.11 0.45 8.35e-18 Hair morphology; CRC cis rs736408 0.677 rs1042779 chr3:52821011 A/G cg11645453 chr3:52864694 ITIH4 0.38 6.83 0.35 4.05e-11 Bipolar disorder; CRC cis rs73206853 1.000 rs73206853 chr12:110708746 A/C cg12870014 chr12:110450643 ANKRD13A 0.56 6.53 0.34 2.54e-10 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg00979634 chr1:16011290 PLEKHM2 0.48 6.82 0.35 4.27e-11 Response to antipsychotic treatment; CRC cis rs9788721 0.802 rs56219465 chr15:78742579 A/G cg18825076 chr15:78729989 IREB2 -0.47 -7.16 -0.37 5.31e-12 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio;Emphysema imaging phenotypes;Emphysema distribution in smoking;Local histogram emphysema pattern;Post bronchodilator FEV1/FVC ratio in COPD; CRC cis rs1862618 0.671 rs173763 chr5:56225418 G/A cg20203395 chr5:56204925 C5orf35 -0.59 -7.99 -0.4 2.32e-14 Initial pursuit acceleration; CRC cis rs4972806 0.849 rs1542180 chr2:177028767 C/T cg13092806 chr2:177043255 NA 0.79 12.4 0.56 3.04e-29 IgG glycosylation; CRC cis rs6968419 0.674 rs1918911 chr7:115906748 G/T cg02561103 chr7:115862891 TES -0.44 -6.64 -0.34 1.3e-10 Intraocular pressure; CRC cis rs7772486 0.790 rs6570724 chr6:146151283 T/C cg23711669 chr6:146136114 FBXO30 0.67 11.46 0.53 7.99e-26 Lobe attachment (rater-scored or self-reported); CRC cis rs4819052 0.840 rs914217 chr21:46698299 A/G cg02159808 chr21:46707872 POFUT2;LOC642852 0.64 7.67 0.39 1.96e-13 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs10504229 0.906 rs7006539 chr8:58178799 A/T cg05313129 chr8:58192883 C8orf71 -0.47 -6.83 -0.35 4.01e-11 Developmental language disorder (linguistic errors); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg23679333 chr2:53995338 LOC100302652;ASB3;CHAC2 0.42 6.12 0.32 2.69e-9 Intelligence (multi-trait analysis); CRC cis rs4727027 0.870 rs11524138 chr7:148799125 G/A cg12479418 chr7:148823350 ZNF425;ZNF398 0.45 6.04 0.32 4.15e-9 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC cis rs2032447 0.966 rs3752416 chr6:26045929 T/C cg03264133 chr6:25882463 NA -0.43 -6.02 -0.32 4.59e-9 Intelligence (multi-trait analysis); CRC cis rs28386778 0.897 rs7207005 chr17:61860355 A/G cg11494091 chr17:61959527 GH2 0.62 10.57 0.5 1.11e-22 Prudent dietary pattern; CRC cis rs9517320 0.935 rs1886089 chr13:99124356 C/T cg07423050 chr13:99094983 FARP1 0.4 6.35 0.33 7.27e-10 Longevity; CRC cis rs79149102 0.579 rs7342601 chr15:75306795 G/T cg15902774 chr15:75289873 SCAMP5 -0.49 -5.8 -0.3 1.55e-8 Lung cancer; CRC trans rs7267979 1.000 rs6050573 chr20:25366065 C/G cg17903999 chr18:56338584 MALT1 -0.43 -7.26 -0.37 2.86e-12 Liver enzyme levels (alkaline phosphatase); CRC cis rs12908161 1.000 rs35960805 chr15:85343980 T/G cg11189052 chr15:85197271 WDR73 0.57 8.17 0.41 6.61e-15 Schizophrenia; CRC trans rs1814175 0.645 rs7928714 chr11:49887622 G/A cg21153622 chr11:89784906 NA -0.39 -6.17 -0.32 2.04e-9 Height; CRC cis rs853679 0.550 rs34477097 chr6:28197186 C/T cg12273811 chr6:28175739 NA 0.59 7.68 0.39 1.8e-13 Depression; CRC cis rs1799949 0.896 rs8176086 chr17:41274778 G/A cg19454999 chr17:41278357 BRCA1;NBR2 0.54 8.58 0.43 3.79e-16 Menopause (age at onset); CRC trans rs1814175 0.817 rs10839358 chr11:49770972 G/A cg11707556 chr5:10655725 ANKRD33B -0.42 -8.05 -0.41 1.5e-14 Height; CRC cis rs3204270 0.639 rs7216239 chr17:79660187 C/T cg09655341 chr17:79618100 PDE6G 0.59 6.92 0.36 2.37e-11 Dental caries; CRC cis rs6831352 0.918 rs13138294 chr4:100062675 T/G cg13256891 chr4:100009986 ADH5 -0.65 -8.88 -0.44 4.51e-17 Alcohol dependence; CRC cis rs4719841 0.662 rs9639523 chr7:25991977 A/C cg24254488 chr7:25991654 NA 0.3 6.32 0.33 8.48e-10 Triglyceride levels; CRC cis rs2486012 1.000 rs1766968 chr1:44403042 T/C cg12908607 chr1:44402522 ARTN 0.46 5.91 0.31 8.59e-9 Intelligence (multi-trait analysis); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg18880390 chr1:175162128 KIAA0040 0.47 6.67 0.35 1.11e-10 Response to antipsychotic treatment; CRC cis rs9916302 0.904 rs7503705 chr17:37669704 A/G cg00129232 chr17:37814104 STARD3 -0.54 -8.18 -0.41 6.31e-15 Glomerular filtration rate (creatinine); CRC cis rs1552244 1.000 rs9849434 chr3:10133710 A/G cg16606324 chr3:10149918 C3orf24 -0.69 -9.68 -0.47 1.11e-19 Alzheimer's disease; CRC cis rs853679 0.517 rs4713137 chr6:28083521 C/G cg12172441 chr6:28176163 NA 0.62 7.27 0.37 2.56e-12 Depression; CRC cis rs7666738 0.830 rs11947578 chr4:98930462 T/G cg17366294 chr4:99064904 C4orf37 0.43 7.32 0.37 1.95e-12 Colonoscopy-negative controls vs population controls; CRC cis rs11577318 0.853 rs11247913 chr1:26648551 G/C cg00852783 chr1:26633632 UBXN11 0.48 6.89 0.35 2.89e-11 Granulocyte percentage of myeloid white cells; CRC trans rs6956675 0.915 rs7795023 chr7:62652291 C/T cg01314568 chr7:57830625 NA -0.63 -8.98 -0.44 2.13e-17 Obesity-related traits; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg18622001 chr10:126150304 LHPP 0.4 6.52 0.34 2.59e-10 Liver disease severity in Alagille syndrome; CRC cis rs1153858 1.000 rs2066090 chr15:45650018 T/C cg21132104 chr15:45694354 SPATA5L1 0.58 8.74 0.43 1.23e-16 Homoarginine levels; CRC cis rs875971 0.862 rs9791712 chr7:66105163 C/G cg12463550 chr7:65579703 CRCP -0.45 -6.1 -0.32 3e-9 Aortic root size; CRC trans rs1814175 0.566 rs1811673 chr11:49602134 A/G cg15704280 chr7:45808275 SEPT13 -0.77 -10.37 -0.5 5.36e-22 Height; CRC cis rs1707322 0.964 rs785509 chr1:46527300 G/A cg03146154 chr1:46216737 IPP -0.52 -7.0 -0.36 1.42e-11 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs3820068 0.581 rs72645893 chr1:15930943 C/G cg27534772 chr1:16042836 PLEKHM2 0.54 10.46 0.5 2.7e-22 Systolic blood pressure; CRC cis rs798554 0.679 rs7784066 chr7:2819727 T/A cg04166393 chr7:2884313 GNA12 0.49 7.1 0.36 7.93e-12 Height; CRC cis rs172166 0.694 rs1770131 chr6:28086413 C/T cg10876282 chr6:28092338 ZSCAN16 0.5 6.6 0.34 1.61e-10 Cardiac Troponin-T levels; CRC cis rs67311347 1.000 rs11539046 chr3:40503809 G/A cg09455208 chr3:40491958 NA -0.48 -9.49 -0.46 4.71e-19 Renal cell carcinoma; CRC cis rs6867032 0.527 rs4371796 chr5:1977785 C/T cg26168224 chr5:2018326 NA -0.79 -9.92 -0.48 1.81e-20 Gut microbiome composition (winter); CRC cis rs4563143 0.514 rs112540771 chr19:29316100 C/T cg14983838 chr19:29218262 NA 0.47 6.29 0.33 9.85e-10 Methadone dose in opioid dependence; CRC cis rs6951245 1.000 rs74366004 chr7:1088630 A/C cg03188948 chr7:1209495 NA 0.64 6.46 0.34 3.71e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs2228479 0.717 rs2286392 chr16:89809549 A/G cg19635926 chr16:89946313 TCF25 0.57 5.94 0.31 7.24e-9 Skin colour saturation; CRC cis rs1178968 0.818 rs2262777 chr7:72786490 A/T cg25889504 chr7:72793014 NA 0.52 5.9 0.31 9.14e-9 Triglyceride levels; CRC cis rs17270561 0.609 rs9358884 chr6:25756592 A/G cg16482183 chr6:26056742 HIST1H1C 0.83 10.58 0.5 1e-22 Iron status biomarkers; CRC cis rs1534166 0.647 rs1464937 chr3:133536655 C/G cg27366882 chr3:133540807 NA -0.6 -9.04 -0.45 1.4e-17 Alcohol consumption (transferrin glycosylation); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg17080073 chr3:39447926 RPSA 0.41 5.97 0.31 6.24e-9 Intelligence (multi-trait analysis); CRC cis rs7249142 0.549 rs10854012 chr19:19295719 C/T cg26504305 chr19:19281019 LOC729991-MEF2B;MEF2B -0.44 -8.84 -0.44 6.01e-17 IgG glycosylation; CRC cis rs1799949 0.965 rs35521261 chr17:41313612 A/G cg25072359 chr17:41440525 NA 0.46 6.98 0.36 1.67e-11 Menopause (age at onset); CRC cis rs2836974 0.602 rs2836987 chr21:40706594 C/T cg06238570 chr21:40685208 BRWD1 -0.82 -12.54 -0.57 9.86e-30 Cognitive function; CRC cis rs7705042 0.828 rs1835966 chr5:141501508 C/T cg08523384 chr5:141488047 NDFIP1 -0.35 -6.09 -0.32 3.17e-9 Asthma; CRC cis rs780096 0.526 rs780112 chr2:27665361 C/G cg21248554 chr2:27665150 KRTCAP3 -0.34 -7.97 -0.4 2.71e-14 Total body bone mineral density; CRC cis rs755249 0.567 rs3818806 chr1:39748271 G/A cg18385671 chr1:39797026 MACF1 -0.42 -5.85 -0.31 1.2e-8 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs9649465 0.542 rs616297 chr7:123426949 A/G cg03229431 chr7:123269106 ASB15 0.6 9.67 0.47 1.21e-19 Migraine; CRC cis rs2204008 0.745 rs8189516 chr12:38239084 C/T cg26384229 chr12:38710491 ALG10B 0.68 9.09 0.45 9.67e-18 Bladder cancer; CRC cis rs9611565 0.625 rs9611606 chr22:41931074 A/G cg06481639 chr22:41940642 POLR3H -0.52 -5.97 -0.31 6.25e-9 Vitiligo; CRC cis rs798554 0.757 rs1182187 chr7:2870454 T/G cg04166393 chr7:2884313 GNA12 0.48 6.43 0.33 4.48e-10 Height; CRC cis rs1347297 0.774 rs9973732 chr2:179281435 A/G cg03991736 chr2:179345203 MIR548N;PLEKHA3 -0.4 -5.76 -0.3 1.93e-8 Alzheimer disease and age of onset; CRC cis rs7666738 0.830 rs7696686 chr4:98938445 T/C cg05340658 chr4:99064831 C4orf37 0.6 9.35 0.46 1.41e-18 Colonoscopy-negative controls vs population controls; CRC cis rs10504229 0.683 rs73603874 chr8:58108340 G/A cg05313129 chr8:58192883 C8orf71 -0.43 -5.83 -0.31 1.36e-8 Developmental language disorder (linguistic errors); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg26684574 chr20:48532295 SPATA2 0.42 6.61 0.34 1.55e-10 Liver disease severity in Alagille syndrome; CRC trans rs2228479 0.850 rs12599473 chr16:89827435 A/C cg24644049 chr4:85504048 CDS1 0.86 6.93 0.36 2.29e-11 Skin colour saturation; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg26770187 chr3:14693171 C3orf19 0.5 6.5 0.34 3.02e-10 Thyroid stimulating hormone; CRC cis rs2797160 1.000 rs2211420 chr6:125995549 A/G cg05901451 chr6:126070800 HEY2 -0.38 -5.81 -0.31 1.45e-8 Endometrial cancer; CRC cis rs1065852 0.526 rs4822079 chr22:42394612 G/C cg22189786 chr22:42395067 WBP2NL 0.43 6.23 0.33 1.4e-9 Response to serotonin reuptake inhibitors in major depressive disorder (plasma drug and metabolite levels); CRC cis rs10504229 0.906 rs114627636 chr8:58173732 C/T cg20607798 chr8:58055168 NA 0.52 5.67 0.3 3.12e-8 Developmental language disorder (linguistic errors); CRC cis rs7255436 0.965 rs7254882 chr19:8453822 A/G cg16745616 chr19:8428856 ANGPTL4 -0.48 -7.65 -0.39 2.24e-13 HDL cholesterol; CRC cis rs9648716 0.577 rs11769042 chr7:140460169 T/C cg10747023 chr7:140774559 NA 0.42 5.68 0.3 3.01e-8 Type 2 diabetes; CRC cis rs754466 0.580 rs10824571 chr10:79531931 G/A cg26805224 chr10:79626177 DLG5 -0.5 -7.36 -0.38 1.44e-12 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs17401966 0.838 rs61775885 chr1:10281445 T/C cg19773385 chr1:10388646 KIF1B -0.63 -9.66 -0.47 1.37e-19 Hepatocellular carcinoma; CRC cis rs2760061 0.626 rs594916 chr1:228133544 C/A cg02753203 chr1:228287806 NA -0.62 -9.2 -0.45 4.33e-18 Diastolic blood pressure; CRC cis rs10504229 0.683 rs16921808 chr8:58106049 C/T cg02290350 chr8:58132656 NA -0.56 -7.32 -0.37 1.93e-12 Developmental language disorder (linguistic errors); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg21556389 chr17:1957370 HIC1 0.35 6.47 0.34 3.48e-10 Liver disease severity in Alagille syndrome; CRC cis rs7618915 1.000 rs3852064 chr3:52349412 G/T cg15147215 chr3:52552868 STAB1 -0.53 -7.92 -0.4 3.81e-14 Bipolar disorder; CRC cis rs9747201 0.962 rs62078313 chr17:80116708 A/C cg14673194 chr17:80132900 CCDC57 0.49 6.3 0.33 9.59e-10 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs1552244 0.872 rs35988239 chr3:10074145 G/T cg08888203 chr3:10149979 C3orf24 0.73 8.59 0.43 3.52e-16 Alzheimer's disease; CRC cis rs2408955 0.504 rs11168441 chr12:48576054 G/A cg24011408 chr12:48396354 COL2A1 0.46 6.49 0.34 3.13e-10 Glycated hemoglobin levels; CRC cis rs116095464 0.558 rs9312978 chr5:221930 C/G cg22496380 chr5:211416 CCDC127 -0.95 -9.42 -0.46 8.46e-19 Breast cancer; CRC cis rs4974559 0.690 rs28641665 chr4:1288781 G/T cg02980000 chr4:1222292 CTBP1 0.71 7.97 0.4 2.59e-14 Systolic blood pressure; CRC cis rs4731207 0.570 rs7784614 chr7:124677191 C/G cg23710748 chr7:124431027 NA -0.39 -6.11 -0.32 2.83e-9 Cutaneous malignant melanoma; CRC trans rs1997103 1.000 rs2331063 chr7:55408914 A/G cg20935933 chr6:143382018 AIG1 0.51 6.65 0.34 1.25e-10 QRS interval (sulfonylurea treatment interaction); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg01098771 chr19:4969087 KDM4B 0.4 6.21 0.32 1.63e-9 Intelligence (multi-trait analysis); CRC trans rs2727020 0.521 rs7946190 chr11:49521964 T/A cg15704280 chr7:45808275 SEPT13 0.76 10.03 0.48 7.78e-21 Coronary artery disease; CRC cis rs875971 0.508 rs10258739 chr7:66062935 A/T cg00343986 chr7:65444356 GUSB -0.47 -7.02 -0.36 1.26e-11 Aortic root size; CRC cis rs10512697 0.803 rs62333968 chr5:3579447 A/C cg19473799 chr5:3511975 NA -0.72 -5.67 -0.3 3.1e-8 Immune response to smallpox vaccine (IL-6); CRC cis rs123509 0.687 rs73077208 chr3:42835205 G/A cg12982090 chr3:42733453 KBTBD5 -0.56 -6.83 -0.35 4.18e-11 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs7258465 1.000 rs10425982 chr19:18586519 T/A cg10790698 chr19:18539756 SSBP4 -0.45 -8.71 -0.43 1.5e-16 Breast cancer; CRC cis rs4819052 0.851 rs4819042 chr21:46660072 A/G cg02159808 chr21:46707872 POFUT2;LOC642852 0.49 6.41 0.33 5.19e-10 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC trans rs1814175 0.765 rs1794141 chr11:49914135 G/C cg11707556 chr5:10655725 ANKRD33B -0.44 -8.31 -0.42 2.52e-15 Height; CRC cis rs6432018 0.964 rs7565646 chr2:9728879 A/G cg12832956 chr2:9616023 IAH1 -0.38 -5.64 -0.3 3.73e-8 Heart rate variability traits; CRC cis rs2072499 0.750 rs55675376 chr1:156165881 C/T cg25208724 chr1:156163844 SLC25A44 1.01 16.32 0.67 2.7e-44 Testicular germ cell tumor; CRC trans rs9929218 0.551 rs4783663 chr16:68720271 T/C cg04657470 chr2:198365150 HSPE1;HSPD1 1.22 30.69 0.86 1.43e-98 Colorectal cancer; CRC cis rs2033711 0.870 rs7259841 chr19:58951123 T/C cg13877915 chr19:58951672 ZNF132 0.51 8.18 0.41 6.32e-15 Uric acid clearance; CRC cis rs10946940 0.864 rs13201411 chr6:27498217 G/C cg06470822 chr6:28175283 NA -0.52 -7.08 -0.36 8.63e-12 Systemic lupus erythematosus; CRC cis rs10504229 0.683 rs67492041 chr8:58140077 G/A cg22535103 chr8:58192502 C8orf71 -0.7 -9.34 -0.46 1.47e-18 Developmental language disorder (linguistic errors); CRC cis rs6089584 0.888 rs6061981 chr20:60618973 T/C cg23262073 chr20:60523788 NA -0.46 -7.24 -0.37 3.25e-12 Body mass index; CRC cis rs9467711 0.606 rs2072806 chr6:26385093 C/G cg12315302 chr6:26189340 HIST1H4D 0.85 6.61 0.34 1.59e-10 Autism spectrum disorder or schizophrenia; CRC cis rs6502050 0.777 rs7406162 chr17:80086386 C/T cg11859384 chr17:80120422 CCDC57 0.37 5.83 0.31 1.36e-8 Life satisfaction; CRC cis rs394563 0.619 rs4895787 chr6:149646500 G/A cg11245181 chr6:149772854 ZC3H12D 0.53 9.22 0.45 3.64e-18 Dupuytren's disease; CRC cis rs7829975 0.593 rs2921051 chr8:8320104 C/A cg06636001 chr8:8085503 FLJ10661 0.58 9.03 0.45 1.49e-17 Mood instability; CRC cis rs4604732 0.631 rs1106720 chr1:247624681 T/C cg12758973 chr1:247694275 LOC148824;OR2C3 0.42 6.19 0.32 1.78e-9 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CRC cis rs344364 0.602 rs7188401 chr16:1876949 G/C cg03013636 chr16:1946785 NA 0.4 5.75 0.3 2.09e-8 Glomerular filtration rate in chronic kidney disease; CRC cis rs6502050 0.635 rs9889327 chr17:80087839 G/A cg11859384 chr17:80120422 CCDC57 -0.37 -5.92 -0.31 7.94e-9 Life satisfaction; CRC cis rs875971 1.000 rs6946143 chr7:65579722 A/C cg18912574 chr7:65842487 NCRNA00174 0.32 5.63 0.3 3.78e-8 Aortic root size; CRC cis rs172166 0.694 rs203884 chr6:28077374 G/T cg20615401 chr6:28092323 ZSCAN16 0.43 5.66 0.3 3.35e-8 Cardiac Troponin-T levels; CRC cis rs3806843 1.000 rs10477033 chr5:140169603 G/C cg19875535 chr5:140030758 IK 0.55 8.7 0.43 1.58e-16 Depressive symptoms (multi-trait analysis); CRC cis rs10078 0.571 rs2561664 chr5:459793 T/C cg24955955 chr5:415729 AHRR 0.66 6.46 0.34 3.75e-10 Fat distribution (HIV); CRC cis rs6570726 0.791 rs425999 chr6:145819370 C/A cg23711669 chr6:146136114 FBXO30 0.74 12.97 0.58 2.27e-31 Lobe attachment (rater-scored or self-reported); CRC cis rs2307022 0.586 rs4783557 chr16:68403945 T/C cg02226672 chr16:68398533 SMPD3 0.29 5.68 0.3 2.98e-8 Body mass index; CRC cis rs4713118 0.662 rs149946 chr6:27970031 A/C cg15786705 chr6:28176104 NA -0.68 -9.6 -0.47 2.11e-19 Parkinson's disease; CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg25998860 chr5:126853954 PRRC1 -0.55 -6.72 -0.35 7.89e-11 Diisocyanate-induced asthma; CRC trans rs61931739 0.500 rs6488218 chr12:34452587 T/C cg13010199 chr12:38710504 ALG10B 0.43 6.05 0.32 3.86e-9 Morning vs. evening chronotype; CRC cis rs4660214 0.666 rs7538300 chr1:39652764 C/A cg11070191 chr1:39582205 MACF1 0.36 5.76 0.3 1.9e-8 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs12476592 0.571 rs262518 chr2:63891335 A/G cg10828910 chr2:63850056 LOC388955 0.51 6.44 0.33 4.22e-10 Childhood ear infection; CRC cis rs1552244 0.882 rs7633769 chr3:10020622 C/T cg18598329 chr3:10140678 FANCD2;C3orf24 -0.83 -11.7 -0.54 1.11e-26 Alzheimer's disease; CRC cis rs3741404 0.609 rs641430 chr11:63869531 C/T cg19465662 chr11:63993652 NUDT22;TRPT1 -0.6 -9.26 -0.45 2.74e-18 Platelet count; CRC cis rs847649 0.731 rs10808120 chr7:102672234 A/G cg18108683 chr7:102477205 FBXL13 -0.5 -7.83 -0.4 6.81e-14 Morning vs. evening chronotype; CRC cis rs875971 0.545 rs6460281 chr7:65681115 A/C cg11764359 chr7:65958608 NA 0.44 5.6 0.3 4.49e-8 Aortic root size; CRC cis rs7727544 0.709 rs272852 chr5:131688767 G/A cg12564285 chr5:131593104 PDLIM4 0.34 6.07 0.32 3.61e-9 Blood metabolite levels; CRC cis rs7615952 0.641 rs7618515 chr3:125790578 C/T cg04553112 chr3:125709451 NA -0.51 -6.0 -0.31 5.07e-9 Blood pressure (smoking interaction); CRC cis rs2019137 0.868 rs6755639 chr2:113981810 A/G cg01577475 chr2:114033581 PAX8;LOC440839 -0.24 -5.98 -0.31 5.96e-9 Lymphocyte counts; CRC cis rs3741151 0.686 rs7114376 chr11:73227361 T/C cg17517138 chr11:73019481 ARHGEF17 0.56 6.0 0.31 5.35e-9 GIP levels in response to oral glucose tolerance test (120 minutes); CRC cis rs17270561 0.636 rs4145218 chr6:25746083 G/A cg17691542 chr6:26056736 HIST1H1C 0.69 8.63 0.43 2.57e-16 Iron status biomarkers; CRC cis rs7107174 1.000 rs2373115 chr11:78091150 G/T cg02023728 chr11:77925099 USP35 0.45 7.64 0.39 2.4e-13 Testicular germ cell tumor; CRC cis rs4722166 0.630 rs2091115 chr7:22810166 G/T cg05472934 chr7:22766657 IL6 0.81 13.71 0.6 3.69e-34 Lung cancer; CRC cis rs798554 0.757 rs1182188 chr7:2869985 T/C cg04166393 chr7:2884313 GNA12 0.48 6.45 0.34 3.9e-10 Height; CRC cis rs140364877 1 rs140364877 chr7:1885178 C/T cg22963979 chr7:1858916 MAD1L1 -0.57 -8.93 -0.44 3.16e-17 Autism spectrum disorder or schizophrenia; CRC cis rs6089584 0.507 rs6061989 chr20:60627893 C/T cg06108461 chr20:60628389 TAF4 -0.74 -11.99 -0.55 1.01e-27 Body mass index; CRC cis rs72634258 0.786 rs4268374 chr1:8174083 G/T cg26816564 chr1:7831052 VAMP3 -0.46 -5.63 -0.3 3.89e-8 Inflammatory bowel disease; CRC cis rs1348850 0.914 rs7604673 chr2:178392346 A/G cg02961200 chr2:178257176 LOC100130691;AGPS 0.61 8.67 0.43 2.04e-16 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs1559088 0.948 rs10410778 chr19:33592301 C/A cg27124370 chr19:33622961 WDR88 0.45 6.3 0.33 9.74e-10 Bone ultrasound measurement (broadband ultrasound attenuation); CRC trans rs11885103 0.543 rs2724925 chr2:562458 G/A cg12228919 chr15:44955936 SPG11 -0.46 -6.84 -0.35 3.98e-11 Heschl's gyrus morphology; CRC cis rs4853012 0.838 rs12619982 chr2:74356022 G/A cg20891558 chr2:74357851 NA 0.68 10.31 0.49 8.56e-22 Gestational age at birth (maternal effect); CRC cis rs7666738 0.830 rs28887893 chr4:98963006 G/A cg17366294 chr4:99064904 C4orf37 0.43 7.36 0.38 1.49e-12 Colonoscopy-negative controls vs population controls; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg25598908 chr1:100731592 RTCD1 0.4 5.98 0.31 5.76e-9 Intelligence (multi-trait analysis); CRC cis rs6951245 0.529 rs10262070 chr7:1141738 C/T cg21664854 chr7:1097933 C7orf50;GPR146 0.58 7.35 0.38 1.59e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC trans rs1997103 1.000 rs7779040 chr7:55412947 T/C cg20935933 chr6:143382018 AIG1 0.5 6.46 0.34 3.66e-10 QRS interval (sulfonylurea treatment interaction); CRC cis rs4566357 0.615 rs6436644 chr2:227914275 T/A cg11843606 chr2:227700838 RHBDD1 -0.44 -6.86 -0.35 3.42e-11 Coronary artery disease; CRC cis rs1862618 0.853 rs1423621 chr5:56101035 G/T cg24531977 chr5:56204891 C5orf35 -0.78 -10.3 -0.49 9.48e-22 Initial pursuit acceleration; CRC cis rs4144743 0.941 rs7211563 chr17:45324061 T/C cg18085866 chr17:45331354 ITGB3 -0.59 -8.11 -0.41 1.02e-14 Body mass index; CRC cis rs6674176 0.628 rs12145999 chr1:44428632 C/T cg13606994 chr1:44402422 ARTN -0.36 -6.05 -0.32 3.84e-9 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Cognitive ability; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg11602459 chr20:39765965 PLCG1 0.46 6.65 0.34 1.21e-10 Anxiety disorder; CRC cis rs9467711 0.584 rs34244947 chr6:26761745 T/C cg12315302 chr6:26189340 HIST1H4D 0.96 6.62 0.34 1.43e-10 Autism spectrum disorder or schizophrenia; CRC cis rs4654899 0.680 rs2305463 chr1:21180181 C/T cg02927042 chr1:21476669 EIF4G3 0.36 5.61 0.3 4.39e-8 Superior frontal gyrus grey matter volume; CRC cis rs875971 0.660 rs79009421 chr7:66068509 G/C cg18876405 chr7:65276391 NA -0.62 -11.14 -0.52 1.17e-24 Aortic root size; CRC cis rs798554 1.000 rs798548 chr7:2760935 A/G cg19346786 chr7:2764209 NA -0.41 -7.56 -0.38 3.95e-13 Height; CRC cis rs7113874 0.524 rs10840083 chr11:8608636 C/T cg02811074 chr11:8615871 STK33 0.34 5.88 0.31 1.02e-8 Body mass index in physically active individuals;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs2295359 0.824 rs4655679 chr1:67599657 A/G cg17031739 chr1:67600172 NA -0.51 -8.03 -0.4 1.7e-14 Psoriasis; CRC cis rs7647973 1.000 rs12583 chr3:49571462 G/T cg07690219 chr3:49449608 TCTA;RHOA 0.54 6.12 0.32 2.6e-9 Menarche (age at onset); CRC cis rs10746514 0.833 rs12039526 chr1:232272599 C/T cg09506761 chr1:232265262 NA -0.45 -6.39 -0.33 5.68e-10 Response to statin therapy; CRC cis rs362272 0.545 rs2749782 chr4:3339761 A/G cg01612440 chr4:3296283 NA 0.41 5.93 0.31 7.47e-9 Serum sulfate level; CRC cis rs17401966 0.931 rs12753426 chr1:10372110 T/C cg19773385 chr1:10388646 KIF1B -0.62 -9.57 -0.47 2.56e-19 Hepatocellular carcinoma; CRC trans rs6430538 0.646 rs6734820 chr2:135536808 A/G cg14471455 chr9:80332956 NA -0.39 -6.2 -0.32 1.64e-9 Parkinson's disease; CRC cis rs2243480 1.000 rs937108 chr7:65428452 G/A cg12463550 chr7:65579703 CRCP 0.63 6.11 0.32 2.82e-9 Diabetic kidney disease; CRC cis rs7552404 0.727 rs1159214 chr1:76317910 G/T cg05598546 chr1:76251766 SNORD45C;RABGGTB -0.5 -5.73 -0.3 2.21e-8 Blood metabolite levels;Acylcarnitine levels; CRC cis rs2303759 0.709 rs10414921 chr19:49823047 C/T cg22307029 chr19:49891270 CCDC155 0.68 9.05 0.45 1.32e-17 Multiple sclerosis; CRC cis rs5769707 0.933 rs2157444 chr22:49994292 A/G cg20744362 chr22:50050164 C22orf34 0.31 6.31 0.33 8.83e-10 Monocyte count;Monocyte percentage of white cells; CRC cis rs9814567 1.000 rs4955555 chr3:134286427 C/T cg06109529 chr3:134205091 CEP63;ANAPC13 -0.82 -12.35 -0.56 4.64e-29 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs1552244 0.572 rs17032440 chr3:10169819 A/C cg16606324 chr3:10149918 C3orf24 -0.68 -8.05 -0.41 1.5e-14 Alzheimer's disease; CRC cis rs17092148 0.945 rs6060042 chr20:33361721 A/G cg08999081 chr20:33150536 PIGU 0.47 5.83 0.31 1.33e-8 Neuroticism; CRC trans rs11039798 0.588 rs7946443 chr11:48545504 G/A cg15704280 chr7:45808275 SEPT13 0.65 6.72 0.35 8.06e-11 Axial length; CRC cis rs2153535 0.580 rs9406169 chr6:8509470 A/T cg21535247 chr6:8435926 SLC35B3 0.49 7.51 0.38 5.59e-13 Motion sickness; CRC cis rs9787249 0.957 rs7547787 chr1:40220806 C/T cg24920358 chr1:40204285 PPIE 0.59 9.12 0.45 7.77e-18 Blood protein levels; CRC cis rs7119 0.651 rs35577135 chr15:77840074 C/T cg27398640 chr15:77910606 LINGO1 -0.42 -6.85 -0.35 3.62e-11 Type 2 diabetes; CRC cis rs11122272 0.735 rs2749707 chr1:231527316 C/T cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.55 -8.11 -0.41 1.01e-14 Hemoglobin concentration; CRC cis rs10078 0.571 rs890973 chr5:471494 T/C cg24955955 chr5:415729 AHRR 0.64 6.18 0.32 1.86e-9 Fat distribution (HIV); CRC cis rs9463078 0.764 rs6923519 chr6:44864152 A/G cg25276700 chr6:44698697 NA -0.27 -6.59 -0.34 1.71e-10 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; CRC cis rs4728302 0.869 rs10954434 chr7:133597864 A/G cg03336402 chr7:133662267 EXOC4 -0.45 -6.5 -0.34 2.97e-10 Intelligence;Intelligence (multi-trait analysis); CRC cis rs8099014 0.814 rs9966765 chr18:56116790 C/G cg12907477 chr18:56117327 MIR122 0.48 5.86 0.31 1.1e-8 Platelet count; CRC cis rs4478858 0.735 rs6679360 chr1:31817936 G/T cg00250761 chr1:31883323 NA -0.4 -7.53 -0.38 4.98e-13 Alcohol dependence; CRC cis rs7264396 0.887 rs224344 chr20:34036865 G/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.43 -6.98 -0.36 1.63e-11 Total cholesterol levels; CRC cis rs7647973 1.000 rs11928090 chr3:49604904 G/A cg20833759 chr3:49053208 WDR6;DALRD3 0.54 8.13 0.41 9.02e-15 Menarche (age at onset); CRC cis rs6921919 0.583 rs740622 chr6:28398291 T/C cg21251018 chr6:28226885 NKAPL 0.4 6.11 0.32 2.88e-9 Autism spectrum disorder or schizophrenia; CRC cis rs7772486 0.790 rs2253307 chr6:146196181 T/G cg23711669 chr6:146136114 FBXO30 0.75 12.95 0.58 2.77e-31 Lobe attachment (rater-scored or self-reported); CRC trans rs7726839 0.540 rs3762951 chr5:662613 C/G cg11887960 chr12:57824829 NA 0.65 7.31 0.37 2.02e-12 Obesity-related traits; CRC cis rs9467711 0.606 rs9393710 chr6:26367833 A/G cg16898833 chr6:26189333 HIST1H4D 0.76 6.58 0.34 1.88e-10 Autism spectrum disorder or schizophrenia; CRC cis rs5753618 0.509 rs4820951 chr22:31586248 G/A cg07713946 chr22:31675144 LIMK2 -0.39 -5.62 -0.3 4e-8 Colorectal cancer; CRC cis rs4555082 0.834 rs2975217 chr14:105710238 A/C cg13114125 chr14:105738426 BRF1 -0.76 -11.02 -0.52 2.95e-24 Mean platelet volume;Platelet distribution width; CRC cis rs8044995 0.563 rs73615919 chr16:68398862 C/T cg05110241 chr16:68378359 PRMT7 -0.7 -7.6 -0.39 3.08e-13 Schizophrenia; CRC cis rs2274273 0.710 rs67395212 chr14:55591939 T/A cg10130446 chr14:55658398 DLGAP5 -0.42 -5.71 -0.3 2.58e-8 Protein biomarker; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg06552368 chr11:118972898 DPAGT1 0.44 6.46 0.34 3.71e-10 Liver disease severity in Alagille syndrome; CRC cis rs6445525 1.000 rs4688259 chr3:65995266 T/C cg06109867 chr3:66002991 MAGI1 -0.39 -6.46 -0.34 3.66e-10 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs35123781 1.000 rs34510678 chr5:139064835 C/T cg10513866 chr5:139070639 NA 0.45 7.19 0.37 4.27e-12 Schizophrenia; CRC cis rs7274811 0.681 rs210074 chr20:31949756 A/T cg03904042 chr20:32255491 NECAB3;C20orf134 0.41 5.89 0.31 9.73e-9 Height; CRC cis rs597539 0.617 rs672853 chr11:68636362 G/A cg04772025 chr11:68637568 NA 0.49 7.18 0.37 4.8e-12 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs68170813 0.559 rs75932578 chr7:106844694 C/T cg02696742 chr7:106810147 HBP1 -0.6 -6.41 -0.33 5.17e-10 Coronary artery disease; CRC cis rs7833986 0.501 rs2953911 chr8:56948009 G/A cg23139584 chr8:56987506 RPS20;SNORD54 0.91 12.65 0.57 3.7e-30 Height; CRC cis rs1033849 0.507 rs9507259 chr13:24722809 C/G cg14860438 chr13:24731302 NA -0.36 -6.04 -0.32 4.27e-9 Cerebrospinal fluid biomarker levels; CRC cis rs4862750 0.881 rs6813866 chr4:187872161 T/G cg24874828 chr4:187887005 NA -0.33 -5.66 -0.3 3.26e-8 Lobe attachment (rater-scored or self-reported); CRC trans rs9929218 0.953 rs3118235 chr16:68732977 A/G cg04657470 chr2:198365150 HSPE1;HSPD1 0.93 13.42 0.59 4.92e-33 Colorectal cancer; CRC cis rs2228479 0.557 rs62054639 chr16:89821489 C/T cg06558623 chr16:89946397 TCF25 1.13 10.45 0.5 2.85e-22 Skin colour saturation; CRC cis rs6942756 1.000 rs6467233 chr7:128868656 C/T cg02491457 chr7:128862824 NA -0.77 -10.55 -0.5 1.34e-22 White matter hyperintensity burden; CRC cis rs2153535 0.580 rs1414345 chr6:8471537 T/G cg21535247 chr6:8435926 SLC35B3 0.5 7.51 0.38 5.54e-13 Motion sickness; CRC cis rs41271473 0.526 rs942852 chr1:228730748 A/G cg16512390 chr1:228756714 NA 0.64 6.79 0.35 5.19e-11 Chronic lymphocytic leukemia; CRC cis rs6456156 0.526 rs1854853 chr6:167533062 A/G cg05540913 chr6:167530185 CCR6 -0.34 -6.22 -0.32 1.51e-9 Primary biliary cholangitis; CRC cis rs7918232 0.830 rs7087033 chr10:27392522 A/G cg14442939 chr10:27389572 ANKRD26 0.84 9.07 0.45 1.07e-17 Breast cancer; CRC cis rs7224685 0.906 rs9915922 chr17:4083242 T/C cg11204139 chr17:3907470 NA 0.42 5.88 0.31 1.01e-8 Type 2 diabetes; CRC cis rs600806 0.850 rs4970752 chr1:109930852 C/T cg23032129 chr1:109941072 SORT1 -0.28 -6.11 -0.32 2.88e-9 Intelligence (multi-trait analysis); CRC cis rs9811920 0.569 rs793445 chr3:99576644 T/A cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G -0.47 -6.19 -0.32 1.76e-9 Axial length; CRC cis rs780096 0.506 rs2303369 chr2:27715416 C/T cg21248554 chr2:27665150 KRTCAP3 -0.33 -7.3 -0.37 2.24e-12 Total body bone mineral density; CRC cis rs12956009 0.518 rs10164267 chr18:44820032 C/T cg19077165 chr18:44547161 KATNAL2 0.38 5.71 0.3 2.54e-8 Educational attainment (years of education); CRC cis rs853679 0.517 rs4711164 chr6:28115156 C/T cg03623178 chr6:28175578 NA 0.98 12.66 0.57 3.31e-30 Depression; CRC cis rs7666738 0.830 rs7663661 chr4:99014761 A/G cg05340658 chr4:99064831 C4orf37 0.62 9.64 0.47 1.5700000000000001e-19 Colonoscopy-negative controls vs population controls; CRC cis rs4713118 0.621 rs4713132 chr6:28034035 A/G cg03623178 chr6:28175578 NA 0.89 11.83 0.55 3.94e-27 Parkinson's disease; CRC cis rs6504622 0.537 rs197919 chr17:45003675 C/T cg16759221 chr17:45003025 GOSR2 -0.64 -10.57 -0.5 1.15e-22 Orofacial clefts; CRC trans rs7395662 1.000 rs115224187 chr11:48757499 G/A cg21153622 chr11:89784906 NA 0.44 7.09 0.36 8.08e-12 HDL cholesterol; CRC cis rs919433 0.963 rs1896854 chr2:198147776 G/T cg10820045 chr2:198174542 NA -0.52 -10.23 -0.49 1.68e-21 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC cis rs17270561 0.609 rs9393665 chr6:25744284 G/A cg16482183 chr6:26056742 HIST1H1C 0.83 10.69 0.51 4.46e-23 Iron status biomarkers; CRC cis rs11971779 0.553 rs10269108 chr7:139106332 G/A cg23387468 chr7:139079360 LUC7L2 0.41 7.05 0.36 1.04e-11 Diisocyanate-induced asthma; CRC cis rs3733585 0.654 rs4447863 chr4:9938969 T/C cg11266682 chr4:10021025 SLC2A9 -0.52 -10.53 -0.5 1.5e-22 Cleft plate (environmental tobacco smoke interaction); CRC cis rs9911578 0.935 rs12948039 chr17:57045184 C/T cg12560992 chr17:57184187 TRIM37 0.83 14.8 0.63 2.43e-38 Intelligence (multi-trait analysis); CRC cis rs12137294 0.866 rs1172156 chr1:205220087 C/T cg24159697 chr1:205181237 DSTYK -0.34 -6.29 -0.33 1e-9 Red cell distribution width; CRC cis rs801193 0.839 rs12534943 chr7:66070520 A/G cg00343986 chr7:65444356 GUSB -0.48 -7.11 -0.36 7.48e-12 Aortic root size; CRC cis rs7666738 0.830 rs9992391 chr4:98916052 G/A cg17366294 chr4:99064904 C4orf37 0.42 6.93 0.36 2.24e-11 Colonoscopy-negative controls vs population controls; CRC cis rs10865541 0.902 rs13399186 chr2:3423201 G/T cg22182287 chr2:3452347 TTC15 0.38 6.06 0.32 3.71e-9 Obesity-related traits; CRC cis rs1552244 0.572 rs6442154 chr3:10168785 A/G cg08888203 chr3:10149979 C3orf24 0.71 8.57 0.43 4.18e-16 Alzheimer's disease; CRC cis rs9894429 0.646 rs7210026 chr17:79612382 T/C cg21984481 chr17:79567631 NPLOC4 -0.44 -7.57 -0.39 3.77e-13 Eye color traits; CRC cis rs3087591 0.708 rs2854307 chr17:29652147 G/A cg24425628 chr17:29625626 OMG;NF1 0.71 13.05 0.58 1.15e-31 Hip circumference; CRC cis rs514406 0.825 rs6693210 chr1:53223398 A/G cg27535305 chr1:53392650 SCP2 0.38 6.97 0.36 1.77e-11 Monocyte count; CRC cis rs853679 0.546 rs200952 chr6:27836976 C/T cg26587870 chr6:27730563 NA -0.6 -5.91 -0.31 8.73e-9 Depression; CRC cis rs10504229 0.775 rs56155911 chr8:58163247 C/T cg05313129 chr8:58192883 C8orf71 -0.49 -6.22 -0.32 1.49e-9 Developmental language disorder (linguistic errors); CRC cis rs2120019 0.567 rs8029351 chr15:75177237 A/C cg09165964 chr15:75287851 SCAMP5 -0.63 -7.61 -0.39 2.98e-13 Blood trace element (Zn levels); CRC cis rs9837602 0.507 rs793448 chr3:99532949 G/C cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G -0.49 -6.51 -0.34 2.88e-10 Breast cancer; CRC cis rs6570726 0.935 rs419850 chr6:145827281 A/G cg23711669 chr6:146136114 FBXO30 0.68 12.04 0.55 6.41e-28 Lobe attachment (rater-scored or self-reported); CRC cis rs2836974 0.526 rs418359 chr21:40536734 T/C cg11890956 chr21:40555474 PSMG1 -0.92 -16.25 -0.67 5.39e-44 Cognitive function; CRC cis rs968567 1.000 rs968567 chr11:61595564 C/T cg10868875 chr11:61596307 FADS2 -0.49 -6.09 -0.32 3.13e-9 Blood metabolite levels;Rheumatoid arthritis;Vitiligo;Glycerophospholipid levels; CRC cis rs17401966 0.518 rs10864453 chr1:10407169 T/G cg19773385 chr1:10388646 KIF1B -0.48 -7.44 -0.38 8.95e-13 Hepatocellular carcinoma; CRC cis rs28386778 0.797 rs4968664 chr17:61851366 C/G cg06601766 chr17:61851465 DDX42;CCDC47 0.43 5.92 0.31 7.91e-9 Prudent dietary pattern; CRC cis rs17095355 1.000 rs11194924 chr10:111695773 G/C cg00817464 chr10:111662876 XPNPEP1 -0.59 -7.82 -0.4 7.14e-14 Biliary atresia; CRC cis rs736408 0.716 rs2300149 chr3:52822921 C/T cg11645453 chr3:52864694 ITIH4 0.36 6.12 0.32 2.71e-9 Bipolar disorder; CRC cis rs78456975 1.000 rs13413096 chr2:1553588 G/A cg26248373 chr2:1572462 NA -0.65 -7.15 -0.37 5.76e-12 Placebo response in major depressive disorder (% change in symptom score); CRC cis rs919433 0.927 rs7592748 chr2:198170688 G/A cg10820045 chr2:198174542 NA -0.55 -9.25 -0.45 2.82e-18 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC cis rs6546550 0.901 rs6725425 chr2:70150674 T/C cg02498382 chr2:70120550 SNRNP27 -0.56 -9.52 -0.46 3.78e-19 Prevalent atrial fibrillation; CRC cis rs4728302 0.583 rs12707091 chr7:133185749 A/G cg10665199 chr7:133106180 EXOC4 0.63 9.67 0.47 1.23e-19 Intelligence;Intelligence (multi-trait analysis); CRC cis rs2952156 0.920 rs1018246 chr17:37835240 C/T cg00129232 chr17:37814104 STARD3 -0.69 -12.17 -0.56 2.27e-28 Asthma; CRC cis rs877282 0.945 rs11599043 chr10:777972 C/T cg17470449 chr10:769945 NA 0.55 7.52 0.38 5.38e-13 Uric acid levels; CRC cis rs7769051 0.522 rs6911773 chr6:133128848 T/C cg07930552 chr6:133119739 C6orf192 0.92 7.35 0.38 1.59e-12 Type 2 diabetes nephropathy; CRC cis rs6582630 0.563 rs923281 chr12:38590241 G/A cg13010199 chr12:38710504 ALG10B -0.41 -5.88 -0.31 1.03e-8 Drug-induced liver injury (flucloxacillin); CRC cis rs11958404 0.932 rs113494689 chr5:157428078 G/T cg05962755 chr5:157440814 NA 0.83 11.03 0.52 2.88e-24 IgG glycosylation; CRC cis rs72627123 1.000 rs45559033 chr14:74341124 G/A cg19860245 chr14:74300557 NA -0.51 -5.63 -0.3 3.82e-8 Morning vs. evening chronotype; CRC cis rs7666738 0.791 rs10013680 chr4:99023030 G/C cg17366294 chr4:99064904 C4orf37 0.44 7.19 0.37 4.26e-12 Colonoscopy-negative controls vs population controls; CRC cis rs73200209 0.744 rs11615595 chr12:116470876 T/C cg01776926 chr12:116560359 MED13L -0.64 -7.57 -0.39 3.78e-13 Total body bone mineral density; CRC trans rs7615952 0.512 rs34651730 chr3:125358640 T/C cg08546805 chr12:8549446 NA -0.43 -6.55 -0.34 2.26e-10 Blood pressure (smoking interaction); CRC cis rs911555 0.511 rs2296483 chr14:104029792 G/A cg12935359 chr14:103987150 CKB -0.49 -7.99 -0.4 2.27e-14 Intelligence (multi-trait analysis); CRC cis rs7725052 0.609 rs10043846 chr5:40442902 A/G cg09067459 chr5:40385259 NA 0.39 6.41 0.33 4.92e-10 Pediatric autoimmune diseases; CRC trans rs3808502 0.574 rs4841559 chr8:11416885 C/T cg16141378 chr3:129829833 LOC729375 0.47 7.33 0.37 1.79e-12 Neuroticism; CRC cis rs10986311 0.832 rs10123514 chr9:127142878 T/C cg14243010 chr9:127117328 LOC100129034;PSMB7 -0.39 -5.67 -0.3 3.16e-8 Vitiligo; CRC trans rs7395662 0.526 rs4882001 chr11:48546675 A/G cg21153622 chr11:89784906 NA -0.49 -8.16 -0.41 7.26e-15 HDL cholesterol; CRC cis rs10540 1.000 rs117339389 chr11:505025 T/A cg19913688 chr11:428466 ANO9 -0.68 -6.93 -0.36 2.17e-11 Body mass index; CRC cis rs769267 1.000 rs7247309 chr19:19439631 A/T cg01262667 chr19:19385393 TM6SF2 -0.37 -6.22 -0.32 1.51e-9 Tonsillectomy; CRC cis rs2032447 0.714 rs129129 chr6:25961029 A/G cg03517284 chr6:25882590 NA -0.53 -7.52 -0.38 5.11e-13 Intelligence (multi-trait analysis); CRC cis rs4604732 0.588 rs12045675 chr1:247623915 C/A cg02104434 chr1:247694406 LOC148824;OR2C3 0.61 9.18 0.45 4.79e-18 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CRC cis rs7772486 0.597 rs6912351 chr6:146264071 T/C cg05347473 chr6:146136440 FBXO30 -0.48 -6.96 -0.36 1.86e-11 Lobe attachment (rater-scored or self-reported); CRC cis rs12681288 0.862 rs2004701 chr8:1022287 A/G cg08648136 chr8:956695 NA 0.31 6.02 0.31 4.66e-9 Schizophrenia; CRC trans rs10411161 1.000 rs6509581 chr19:52363882 T/C cg22319618 chr22:45562946 NUP50 -0.52 -6.03 -0.32 4.4e-9 Breast cancer; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg25215340 chr11:2907127 CDKN1C 0.46 5.97 0.31 5.98e-9 Thyroid stimulating hormone; CRC cis rs6831352 0.918 rs6813415 chr4:100048509 T/C cg12011299 chr4:100065546 ADH4 -0.49 -9.27 -0.45 2.61e-18 Alcohol dependence; CRC cis rs2404602 0.684 rs1011084 chr15:77007480 C/G cg23625390 chr15:77176239 SCAPER -0.84 -12.98 -0.58 2.21e-31 Blood metabolite levels; CRC cis rs7412746 0.658 rs2272214 chr1:150931462 C/T cg18016565 chr1:150552671 MCL1 0.44 6.29 0.33 1.01e-9 Melanoma; CRC cis rs1003719 0.715 rs2252893 chr21:38507572 T/C cg10648535 chr21:38446584 PIGP;TTC3 -0.48 -6.7 -0.35 8.99e-11 Eye color traits; CRC cis rs3751196 0.808 rs56123042 chr12:104220257 C/T cg02344784 chr12:104178138 NT5DC3 0.71 7.25 0.37 3.05e-12 Sense of smell; CRC cis rs6912958 0.559 rs173333 chr6:88047754 T/G cg12350822 chr6:88032061 C6orf162;GJB7 0.46 9.42 0.46 8.43e-19 Monocyte percentage of white cells; CRC trans rs7615952 0.641 rs12488180 chr3:125782236 C/T cg07211511 chr3:129823064 LOC729375 -0.72 -9.73 -0.47 7.79e-20 Blood pressure (smoking interaction); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg17913451 chr14:58619030 C14orf37 0.49 7.21 0.37 3.8e-12 Response to antipsychotic treatment; CRC cis rs853679 0.517 rs9393897 chr6:28127710 G/T cg18032046 chr6:28092343 ZSCAN16 -0.51 -5.93 -0.31 7.47e-9 Depression; CRC cis rs4363385 0.747 rs3964619 chr1:152972811 A/C cg25856811 chr1:152973957 SPRR3 -0.26 -7.22 -0.37 3.62e-12 Inflammatory skin disease; CRC cis rs2290159 0.800 rs5746214 chr3:12644753 A/G cg23032965 chr3:12705835 RAF1 0.48 6.21 0.32 1.56e-9 Cholesterol, total; CRC cis rs7493 0.853 rs11770901 chr7:95054480 T/C cg17330251 chr7:94953956 PON1 -0.6 -7.52 -0.38 5.11e-13 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs7918232 0.782 rs7910168 chr10:27465296 G/A cg14240646 chr10:27532245 ACBD5 -0.86 -9.85 -0.48 3.16e-20 Breast cancer; CRC trans rs473651 0.904 rs508274 chr2:239337723 G/A cg13521940 chr21:36262239 RUNX1 -0.41 -6.18 -0.32 1.94e-9 Multiple system atrophy; CRC cis rs4780401 0.632 rs8059262 chr16:11784129 G/T cg01061890 chr16:11836724 TXNDC11 -0.41 -5.72 -0.3 2.4e-8 Rheumatoid arthritis; CRC cis rs9640161 0.636 rs56190213 chr7:150025720 T/C cg13722127 chr7:150037890 RARRES2 0.53 7.89 0.4 4.48e-14 Blood protein levels;Circulating chemerin levels; CRC cis rs909002 0.800 rs2176807 chr1:32092735 T/G cg13919466 chr1:32135498 COL16A1 -0.31 -5.88 -0.31 9.98e-9 Intelligence (multi-trait analysis); CRC cis rs1707322 1.000 rs1707322 chr1:46505147 C/T cg03146154 chr1:46216737 IPP 0.53 7.43 0.38 9.5e-13 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs11148252 0.846 rs7323666 chr13:53006058 T/C cg02158880 chr13:53174818 NA 0.5 7.51 0.38 5.74e-13 Lewy body disease; CRC cis rs2839186 0.564 rs4819215 chr21:47623573 G/A cg26721908 chr21:47610096 LSS -0.45 -7.21 -0.37 3.84e-12 Testicular germ cell tumor; CRC cis rs17152411 1.000 rs7083336 chr10:126590771 T/C cg07906193 chr10:126599966 NA 0.58 6.52 0.34 2.69e-10 Height; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg08273200 chr1:39338480 MYCBP 0.44 6.13 0.32 2.5e-9 Response to antipsychotic treatment; CRC cis rs853679 0.517 rs9368557 chr6:28131537 T/C cg02631126 chr6:28058918 ZSCAN12L1 0.29 5.91 0.31 8.38e-9 Depression; CRC cis rs1401999 0.966 rs4148585 chr3:183670642 A/G cg05044414 chr3:183734942 ABCC5 0.48 8.28 0.42 3.17e-15 Anterior chamber depth; CRC cis rs6840360 1.000 rs3749563 chr4:152596508 T/C cg09659197 chr4:152720779 NA 0.52 11.29 0.53 3.31e-25 Intelligence (multi-trait analysis); CRC cis rs10206020 0.885 rs6720797 chr2:1574340 T/C cg26248373 chr2:1572462 NA -0.83 -12.5 -0.57 1.34e-29 IgG glycosylation; CRC cis rs6088590 1.000 rs6120708 chr20:33335526 G/A cg24642439 chr20:33292090 TP53INP2 0.59 10.68 0.51 4.59e-23 Coronary artery disease; CRC cis rs6460942 0.591 rs6942432 chr7:12338393 A/G cg06484146 chr7:12443880 VWDE -0.6 -6.65 -0.34 1.22e-10 Coronary artery disease; CRC cis rs4731207 0.698 rs2402753 chr7:124448259 A/G cg23710748 chr7:124431027 NA 0.37 5.96 0.31 6.53e-9 Cutaneous malignant melanoma; CRC cis rs28386778 0.897 rs2236736 chr17:61938248 G/T cg06873352 chr17:61820015 STRADA 0.73 13.55 0.6 1.55e-33 Prudent dietary pattern; CRC cis rs11719291 0.915 rs1048940 chr3:48725707 C/T cg07636037 chr3:49044803 WDR6 -0.81 -5.9 -0.31 8.87e-9 Cognitive function; CRC cis rs773506 0.602 rs10761110 chr9:93929884 A/G cg14446406 chr9:93919335 NA -0.47 -8.15 -0.41 7.53e-15 Type 2 diabetes nephropathy; CRC cis rs9303401 0.659 rs35797125 chr17:56736547 G/A cg02118635 chr17:56770003 RAD51C;TEX14 0.78 9.75 0.47 6.87e-20 Cognitive test performance; CRC cis rs981844 0.740 rs10024619 chr4:154684441 A/T cg10279832 chr4:154682576 RNF175 0.38 5.79 0.3 1.65e-8 Response to statins (LDL cholesterol change); CRC cis rs7618915 0.571 rs33964154 chr3:52596914 A/G cg18404041 chr3:52824283 ITIH1 -0.42 -8.75 -0.43 1.13e-16 Bipolar disorder; CRC cis rs4242434 0.819 rs6558173 chr8:22492103 A/C cg03733263 chr8:22462867 KIAA1967 -0.87 -15.08 -0.64 1.97e-39 Exploratory eye movement dysfunction in schizophrenia (cognitive search score); CRC cis rs4713118 0.955 rs9393847 chr6:27687973 G/A cg20933634 chr6:27740509 NA 0.57 7.9 0.4 4.13e-14 Parkinson's disease; CRC cis rs9926296 0.687 rs258317 chr16:89732238 C/T cg01097406 chr16:89675127 NA 0.52 9.55 0.47 3.07e-19 Vitiligo; CRC trans rs1814175 0.817 rs2866863 chr11:49953242 C/T cg03929089 chr4:120376271 NA -0.96 -18.56 -0.72 3.92e-53 Height; CRC cis rs12477438 0.765 rs6722164 chr2:99561527 C/T cg26064155 chr2:99771622 LIPT1;TSGA10 -0.61 -8.42 -0.42 1.14e-15 Chronic sinus infection; CRC cis rs4076764 0.830 rs10917770 chr1:163442214 G/C cg24596788 chr1:163392923 NA -0.63 -9.96 -0.48 1.36e-20 Motion sickness; CRC cis rs853679 0.527 rs853690 chr6:28285482 G/A cg15845792 chr6:28175446 NA 0.47 6.43 0.33 4.4e-10 Depression; CRC trans rs7726839 0.540 rs72705102 chr5:659437 T/C cg11887960 chr12:57824829 NA 0.64 7.18 0.37 4.66e-12 Obesity-related traits; CRC cis rs9818758 0.607 rs9847839 chr3:49289003 T/C cg00383909 chr3:49044727 WDR6 1.14 11.5 0.54 5.77e-26 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; CRC cis rs3820068 0.603 rs6696286 chr1:15968770 C/T cg24675056 chr1:15929824 NA 0.49 6.76 0.35 6.2e-11 Systolic blood pressure; CRC cis rs6500602 0.826 rs9925719 chr16:4461861 A/G cg14951292 chr16:4525986 HMOX2;NMRAL1 0.66 8.34 0.42 2.13e-15 Schizophrenia; CRC cis rs9303280 0.806 rs2305480 chr17:38062196 G/A cg20243544 chr17:37824526 PNMT 0.39 5.84 0.31 1.24e-8 Self-reported allergy; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg19336883 chr11:64085465 PRDX5;TRMT112 0.41 6.44 0.33 4.21e-10 Liver disease severity in Alagille syndrome; CRC cis rs6691722 0.506 rs11587667 chr1:24715435 C/G cg02336364 chr1:24764700 NIPAL3 0.44 7.42 0.38 1.01e-12 Response to interferon beta in multiple sclerosis; CRC cis rs262150 0.659 rs2657340 chr7:158796968 C/T cg10570241 chr7:158785291 NA -0.41 -6.96 -0.36 1.9e-11 Facial morphology (factor 20); CRC cis rs9322193 0.923 rs12195866 chr6:150014470 A/G cg13206674 chr6:150067644 NUP43 0.57 8.27 0.41 3.37e-15 Lung cancer; CRC cis rs847577 0.630 rs13221758 chr7:97719806 A/C cg00277769 chr7:97922759 BAIAP2L1 -0.4 -6.8 -0.35 4.92e-11 Breast cancer; CRC cis rs17023223 0.537 rs12086 chr1:119573860 T/C cg05756136 chr1:119680316 WARS2 -0.52 -6.4 -0.33 5.35e-10 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for BMI in active individuals; CRC cis rs9914988 0.887 rs28873200 chr17:27149512 A/G cg12682573 chr17:27188876 MIR451;MIR144 0.57 7.99 0.4 2.37e-14 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs7666738 0.830 rs6839277 chr4:99015563 C/T cg05340658 chr4:99064831 C4orf37 0.62 9.64 0.47 1.5700000000000001e-19 Colonoscopy-negative controls vs population controls; CRC cis rs734999 0.545 rs4648565 chr1:2570023 A/G cg20673091 chr1:2541236 MMEL1 -0.38 -5.85 -0.31 1.16e-8 Ulcerative colitis; CRC cis rs10924970 0.625 rs12757645 chr1:235497804 T/C cg09010748 chr1:235293032 TOMM20 -0.41 -5.76 -0.3 1.98e-8 Asthma; CRC cis rs6547741 1.000 rs6547740 chr2:27854369 C/T cg27432699 chr2:27873401 GPN1 0.74 13.18 0.59 3.7e-32 Oral cavity cancer; CRC cis rs6502050 0.835 rs8071425 chr17:80117335 C/T cg25804541 chr17:80189381 SLC16A3 0.31 5.98 0.31 5.71e-9 Life satisfaction; CRC cis rs172166 0.561 rs149976 chr6:27987776 C/T cg23161317 chr6:28129485 ZNF389 -0.38 -5.7 -0.3 2.6e-8 Cardiac Troponin-T levels; CRC cis rs9389248 0.500 rs116273677 chr6:135339135 A/C cg22676075 chr6:135203613 NA 0.45 6.94 0.36 2.09e-11 High light scatter reticulocyte percentage of red cells; CRC trans rs877282 1.000 rs112522746 chr10:772288 T/C cg22713356 chr15:30763199 NA 1.15 14.73 0.63 4.62e-38 Uric acid levels; CRC cis rs7737355 0.947 rs10477736 chr5:130922125 T/C cg25547332 chr5:131281432 NA 0.41 5.72 0.3 2.42e-8 Life satisfaction; CRC cis rs11098499 0.739 rs9884728 chr4:120127079 C/T cg24375607 chr4:120327624 NA -0.47 -7.69 -0.39 1.67e-13 Corneal astigmatism; CRC cis rs4713118 0.824 rs9468223 chr6:27740666 C/T cg03623178 chr6:28175578 NA 0.73 9.66 0.47 1.31e-19 Parkinson's disease; CRC cis rs6831352 1.000 rs10017466 chr4:100055800 C/T cg12011299 chr4:100065546 ADH4 0.53 11.35 0.53 2.08e-25 Alcohol dependence; CRC cis rs11123610 0.520 rs35752035 chr2:3721353 G/C cg19052272 chr2:3704530 ALLC -0.62 -7.65 -0.39 2.28e-13 Response to inhaled corticosteroid treatment in asthma (change in FEV1); CRC trans rs2303319 0.504 rs62189047 chr2:162613314 T/A cg09481857 chr22:21368659 P2RX6;MGC16703 -0.65 -6.31 -0.33 9.13e-10 Cognitive function; CRC cis rs514406 0.825 rs9661082 chr1:53245472 A/T cg24675658 chr1:53192096 ZYG11B 0.56 8.12 0.41 9.29e-15 Monocyte count; CRC cis rs6665290 0.935 rs12409755 chr1:227196949 A/T cg10327440 chr1:227177885 CDC42BPA -1.05 -23.43 -0.79 4.22e-72 Myeloid white cell count; CRC cis rs561341 1.000 rs554078 chr17:30330109 A/C cg00745463 chr17:30367425 LRRC37B -0.87 -9.52 -0.46 3.79e-19 Hip circumference adjusted for BMI; CRC cis rs2836974 0.644 rs2410123 chr21:40700093 C/T cg06238570 chr21:40685208 BRWD1 -0.81 -12.83 -0.58 7.91e-31 Cognitive function; CRC cis rs9891119 0.896 rs35950888 chr17:40499198 A/G cg06270615 chr17:40516068 STAT3 -0.27 -5.94 -0.31 7.32e-9 Multiple sclerosis;Crohn's disease; CRC cis rs11212617 1.000 rs2356801 chr11:108281999 G/A cg12106634 chr11:108092400 ATM;NPAT 0.42 6.2 0.32 1.66e-9 Response to metformin in type 2 diabetes (glycemic); CRC cis rs3751196 0.808 rs79928071 chr12:104220071 T/C cg02344784 chr12:104178138 NT5DC3 0.71 7.25 0.37 3.05e-12 Sense of smell; CRC cis rs9399135 0.967 rs2150681 chr6:135375232 A/G cg24558204 chr6:135376177 HBS1L -0.49 -7.79 -0.39 8.6e-14 Red blood cell count; CRC cis rs4665630 0.522 rs114382704 chr2:23951810 G/T cg08063864 chr2:24346004 PFN4;LOC375190 0.96 7.52 0.38 5.32e-13 Hypertension; CRC cis rs2629540 0.889 rs7476729 chr10:126428174 C/G cg08799069 chr10:126477246 METTL10 -0.64 -8.6 -0.43 3.35e-16 Cocaine dependence; CRC cis rs4713118 0.597 rs172166 chr6:28020820 C/G cg21251018 chr6:28226885 NKAPL 0.45 6.51 0.34 2.73e-10 Parkinson's disease; CRC cis rs1008375 1.000 rs6846238 chr4:17629939 A/G cg04450456 chr4:17643702 FAM184B 0.35 5.66 0.3 3.35e-8 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs853679 0.517 rs34716816 chr6:28046169 C/A cg06470822 chr6:28175283 NA 0.98 13.17 0.59 4.07e-32 Depression; CRC cis rs6952808 0.531 rs1107351 chr7:2177093 G/A cg22963979 chr7:1858916 MAD1L1 -0.41 -5.73 -0.3 2.27e-8 Bipolar disorder and schizophrenia; CRC cis rs427941 0.703 rs201435 chr7:101732865 G/C cg06246474 chr7:101738831 CUX1 0.46 7.13 0.37 6.52e-12 Plasma omega-3 polyunsaturated fatty acid level (eicosapentaenoic acid); CRC cis rs6500395 1.000 rs9933329 chr16:48646572 T/C cg04672837 chr16:48644449 N4BP1 0.44 6.4 0.33 5.42e-10 Response to tocilizumab in rheumatoid arthritis; CRC cis rs12477438 0.765 rs2309454 chr2:99595418 G/A cg14399236 chr2:99771627 LIPT1;TSGA10 -0.6 -8.21 -0.41 5.18e-15 Chronic sinus infection; CRC cis rs713587 0.776 rs3731623 chr2:25163783 T/C cg22495460 chr2:25135724 ADCY3 -0.66 -11.1 -0.52 1.62e-24 Body mass index in non-asthmatics; CRC cis rs4819052 1.000 rs13047688 chr21:46669290 G/A cg11663144 chr21:46675770 NA -0.8 -11.92 -0.55 1.75e-27 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs2408955 0.521 rs11168437 chr12:48566156 C/T cg24011408 chr12:48396354 COL2A1 0.45 6.39 0.33 5.56e-10 Glycated hemoglobin levels; CRC cis rs6461049 0.800 rs1860831 chr7:2160931 T/C cg02951883 chr7:2050386 MAD1L1 -0.62 -10.07 -0.49 5.67e-21 Schizophrenia; CRC cis rs3812762 0.833 rs10500707 chr11:8817580 C/T cg00186954 chr11:8933980 ST5;C11orf17 0.4 6.53 0.34 2.43e-10 Hypospadias; CRC cis rs10504229 0.683 rs55986917 chr8:58137210 C/T cg04204079 chr8:58130323 NA -0.45 -5.78 -0.3 1.71e-8 Developmental language disorder (linguistic errors); CRC cis rs7618915 0.501 rs3733045 chr3:52643307 A/G cg05573699 chr3:52720067 GNL3;PBRM1 -0.49 -7.13 -0.37 6.47e-12 Bipolar disorder; CRC cis rs2303759 0.709 rs8102658 chr19:49828855 C/T cg22307029 chr19:49891270 CCDC155 0.68 8.94 0.44 2.78e-17 Multiple sclerosis; CRC trans rs7618501 0.602 rs2624816 chr3:50117312 T/G cg21659725 chr3:3221576 CRBN -0.55 -8.7 -0.43 1.64e-16 Intelligence (multi-trait analysis); CRC cis rs17345786 1.000 rs17345528 chr3:101294830 A/C cg12386194 chr3:101231763 SENP7 -0.54 -7.23 -0.37 3.4e-12 Colonoscopy-negative controls vs population controls; CRC cis rs2880765 0.546 rs11639291 chr15:86064130 G/A cg10818794 chr15:86012489 AKAP13 -0.45 -6.58 -0.34 1.81e-10 Coronary artery disease; CRC cis rs9326248 1.000 rs4938354 chr11:117051165 A/G cg15534755 chr11:117069859 TAGLN 0.35 6.64 0.34 1.32e-10 Blood protein levels; CRC cis rs501120 1.000 rs504799 chr10:44753456 C/T cg09554077 chr10:44749378 NA 0.89 13.32 0.59 1.14e-32 Coronary artery disease;Coronary heart disease; CRC trans rs944990 0.595 rs10123378 chr9:96375217 C/T cg10190698 chr14:50154770 POLE2 0.43 6.42 0.33 4.64e-10 Body mass index; CRC cis rs6088813 1.000 rs6141548 chr20:33971085 A/G cg14752227 chr20:34000481 UQCC -0.36 -5.62 -0.3 3.99e-8 Height; CRC cis rs2836974 0.644 rs1882779 chr21:40690938 T/C cg11644478 chr21:40555479 PSMG1 -0.61 -9.27 -0.45 2.56e-18 Cognitive function; CRC trans rs11098499 0.604 rs2389882 chr4:120566733 A/C cg25214090 chr10:38739885 LOC399744 0.56 8.41 0.42 1.22e-15 Corneal astigmatism; CRC cis rs7552404 0.924 rs1694419 chr1:76219801 C/T cg03433033 chr1:76189801 ACADM 0.72 11.22 0.53 5.76e-25 Blood metabolite levels;Acylcarnitine levels; CRC cis rs7618915 0.571 rs7623199 chr3:52605974 C/T cg07507251 chr3:52567010 NT5DC2 0.46 6.73 0.35 7.48e-11 Bipolar disorder; CRC cis rs6502050 0.835 rs4789678 chr17:80101078 C/T cg25804541 chr17:80189381 SLC16A3 -0.31 -6.08 -0.32 3.24e-9 Life satisfaction; CRC cis rs9911578 1.000 rs11870671 chr17:56605360 A/G cg12560992 chr17:57184187 TRIM37 -0.91 -17.1 -0.69 2.31e-47 Intelligence (multi-trait analysis); CRC cis rs10782582 0.593 rs11164042 chr1:76178440 G/A cg05598546 chr1:76251766 SNORD45C;RABGGTB 0.44 5.73 0.3 2.31e-8 Daytime sleep phenotypes; CRC cis rs796364 0.813 rs7565417 chr2:201057491 G/A cg12253985 chr2:200820533 C2orf60;C2orf47 0.52 6.03 0.32 4.35e-9 Schizophrenia; CRC cis rs12711979 0.509 rs10178286 chr2:3823821 A/G cg17052675 chr2:3827356 NA 0.85 20.71 0.75 1.39e-61 Itch intensity from mosquito bite adjusted by bite size; CRC cis rs12325245 0.536 rs12925676 chr16:58625326 C/T cg01472538 chr16:58549086 SETD6 1.12 7.38 0.38 1.28e-12 Schizophrenia; CRC cis rs883565 0.542 rs6802490 chr3:39033907 T/A cg01426195 chr3:39028469 NA -0.45 -7.57 -0.39 3.81e-13 Handedness; CRC cis rs875971 0.862 rs778736 chr7:65813848 C/T cg00343986 chr7:65444356 GUSB 0.45 6.17 0.32 2.05e-9 Aortic root size; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg19626500 chr19:17445531 ANO8 0.42 6.03 0.32 4.41e-9 Anxiety disorder; CRC cis rs6089584 0.528 rs4925334 chr20:60626769 C/T cg23463467 chr20:60627584 TAF4 0.44 8.31 0.42 2.47e-15 Body mass index; CRC cis rs10089 0.904 rs2228112 chr5:127469859 A/G cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.73 10.28 0.49 1.15e-21 Ileal carcinoids; CRC cis rs9911578 0.933 rs2531725 chr17:56517962 G/A cg05425664 chr17:57184151 TRIM37 -0.51 -7.95 -0.4 3.07e-14 Intelligence (multi-trait analysis); CRC cis rs6951245 0.554 rs4724294 chr7:1139695 G/A cg04025307 chr7:1156635 C7orf50 0.67 8.49 0.42 7.21e-16 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs9463078 0.739 rs1293457 chr6:44758098 T/C cg25276700 chr6:44698697 NA 0.29 7.03 0.36 1.23e-11 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg11976233 chr4:56719715 EXOC1 0.41 7.11 0.36 7.18e-12 Liver disease severity in Alagille syndrome; CRC cis rs8031584 0.697 rs8036176 chr15:31175269 A/G cg08704250 chr15:31115839 NA -0.49 -8.35 -0.42 1.95e-15 Huntington's disease progression; CRC cis rs1448094 0.512 rs12305828 chr12:86249153 C/G cg18827107 chr12:86230957 RASSF9 -0.45 -7.49 -0.38 6.6e-13 Major depressive disorder; CRC trans rs12599106 0.792 rs11648801 chr16:34360980 C/T cg01171360 chr6:293285 DUSP22 -0.48 -6.72 -0.35 7.85e-11 Menopause (age at onset); CRC cis rs8062405 0.720 rs9926245 chr16:28555706 T/A cg16576597 chr16:28551801 NUPR1 0.46 7.11 0.36 7.38e-12 Cognitive ability (multi-trait analysis);Cognitive ability; CRC cis rs13108904 0.967 rs4428235 chr4:1278891 C/T cg00684032 chr4:1343700 KIAA1530 0.48 7.09 0.36 8.27e-12 Obesity-related traits; CRC cis rs1816752 0.905 rs1348110 chr13:24980675 C/T cg02811702 chr13:24901961 NA 0.43 6.0 0.31 5.17e-9 Obesity-related traits; CRC cis rs908922 0.651 rs1988805 chr1:152531495 T/G cg23254163 chr1:152506842 NA 0.45 9.15 0.45 6.31e-18 Hair morphology; CRC cis rs875971 0.660 rs3857686 chr7:66036191 C/T cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.43 -6.31 -0.33 9.14e-10 Aortic root size; CRC cis rs4737010 0.530 rs4026 chr8:41645710 C/T cg17182837 chr8:41585554 ANK1 -0.56 -7.82 -0.4 7.46e-14 Lymphocyte counts;High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Reticulocyte count;Reticulocyte fraction of red cells;Mean corpuscular volume;Immature fraction of reticulocytes;Mean corpuscular hemoglobin concentration; CRC cis rs3924048 0.559 rs4580 chr1:12628188 T/C cg00291366 chr1:12616550 NA 0.52 8.92 0.44 3.21e-17 Optic cup area; CRC cis rs1949733 0.958 rs2631731 chr4:8429817 A/G cg11789530 chr4:8429930 ACOX3 0.81 11.92 0.55 1.84e-27 Response to antineoplastic agents; CRC cis rs4073582 0.595 rs3016319 chr11:65981846 C/T cg16950941 chr11:66035639 RAB1B 0.71 11.97 0.55 1.22e-27 Gout; CRC cis rs10751667 0.666 rs7395823 chr11:942701 T/C ch.11.42038R chr11:967971 AP2A2 0.58 9.85 0.48 3.1e-20 Alzheimer's disease (late onset); CRC cis rs9916302 0.904 rs11654018 chr17:37703740 C/T cg00129232 chr17:37814104 STARD3 0.53 7.93 0.4 3.54e-14 Glomerular filtration rate (creatinine); CRC cis rs6942756 0.713 rs691807 chr7:129076203 G/C cg02491457 chr7:128862824 NA -0.62 -8.27 -0.41 3.47e-15 White matter hyperintensity burden; CRC cis rs1552244 1.000 rs6782602 chr3:10116541 G/T cg08888203 chr3:10149979 C3orf24 0.7 10.01 0.48 8.99e-21 Alzheimer's disease; CRC cis rs9649213 0.593 rs7781916 chr7:97929738 A/G cg00277769 chr7:97922759 BAIAP2L1 -0.61 -10.74 -0.51 2.85e-23 Prostate cancer (SNP x SNP interaction); CRC cis rs17127169 0.536 rs112625995 chr1:65496627 A/G cg13853591 chr1:65468921 NA 0.81 5.67 0.3 3.06e-8 Sitting height ratio; CRC cis rs2153535 0.580 rs7767780 chr6:8453462 A/G cg21535247 chr6:8435926 SLC35B3 0.5 7.52 0.38 5.42e-13 Motion sickness; CRC cis rs921968 0.565 rs6745700 chr2:219639862 T/C cg02176678 chr2:219576539 TTLL4 -0.4 -6.52 -0.34 2.67e-10 Mean corpuscular hemoglobin concentration; CRC cis rs1862618 0.756 rs832548 chr5:56183637 G/C cg12311346 chr5:56204834 C5orf35 -0.79 -10.04 -0.48 7.48e-21 Initial pursuit acceleration; CRC cis rs9287719 0.967 rs6432118 chr2:10749441 C/T cg00105475 chr2:10696890 NA 0.45 7.17 0.37 4.87e-12 Prostate cancer; CRC cis rs8180040 0.620 rs2278963 chr3:47054869 G/T cg27129171 chr3:47204927 SETD2 -0.72 -11.12 -0.52 1.36e-24 Colorectal cancer; CRC cis rs875971 0.862 rs2460432 chr7:65554385 C/T cg18876405 chr7:65276391 NA -0.51 -8.39 -0.42 1.44e-15 Aortic root size; CRC cis rs2239547 0.618 rs13083728 chr3:52868445 G/A cg11645453 chr3:52864694 ITIH4 0.61 10.87 0.51 1e-23 Schizophrenia; CRC cis rs3996993 0.809 rs55815585 chr6:52697601 T/G cg20803780 chr6:52668592 GSTA1 0.36 6.56 0.34 2.07e-10 Hemoglobin concentration; CRC cis rs8180040 0.800 rs6768221 chr3:47296899 C/G cg27129171 chr3:47204927 SETD2 -0.66 -9.98 -0.48 1.13e-20 Colorectal cancer; CRC cis rs13108904 0.935 rs1732102 chr4:1277924 T/C cg21620606 chr4:1342894 KIAA1530 -0.4 -7.2 -0.37 4.07e-12 Obesity-related traits; CRC cis rs6662572 1.000 rs28433203 chr1:46196813 G/T cg03123370 chr1:45965343 CCDC163P;MMACHC 0.51 5.92 0.31 8.32e-9 Blood protein levels; CRC cis rs9814567 1.000 rs9834755 chr3:134206845 G/A cg06109529 chr3:134205091 CEP63;ANAPC13 -0.82 -12.47 -0.57 1.6800000000000001e-29 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs7618915 0.547 rs6976 chr3:52728804 C/T cg10802521 chr3:52805072 NEK4 -0.58 -8.63 -0.43 2.76e-16 Bipolar disorder; CRC cis rs7632954 0.605 rs6790631 chr3:8521605 G/T cg03495237 chr3:8533978 NA 0.37 6.76 0.35 6.14e-11 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs2075371 1.000 rs2244700 chr7:133987374 A/G cg11752832 chr7:134001865 SLC35B4 0.49 7.69 0.39 1.75e-13 Mean platelet volume; CRC cis rs28386778 0.897 rs2665833 chr17:61906846 T/C cg06601766 chr17:61851465 DDX42;CCDC47 0.44 5.94 0.31 7.14e-9 Prudent dietary pattern; CRC cis rs17253792 0.545 rs3742571 chr14:56016704 A/G cg01858014 chr14:56050164 KTN1 -0.88 -6.45 -0.33 4.09e-10 Putamen volume; CRC trans rs57221529 0.766 rs58015612 chr5:580665 A/T cg11887960 chr12:57824829 NA 0.63 6.79 0.35 5.32e-11 Lung disease severity in cystic fibrosis; CRC cis rs12142240 0.698 rs72677589 chr1:46817770 T/C cg00530320 chr1:46809349 NSUN4 0.58 7.96 0.4 2.82e-14 Menopause (age at onset); CRC cis rs1997103 1.000 rs2177803 chr7:55410773 A/G cg17469321 chr7:55412551 NA 0.72 11.28 0.53 3.48e-25 QRS interval (sulfonylurea treatment interaction); CRC cis rs6088590 0.542 rs6059956 chr20:33220070 A/G cg24642439 chr20:33292090 TP53INP2 0.39 6.92 0.36 2.38e-11 Coronary artery disease; CRC trans rs35110281 0.837 rs2838336 chr21:45071741 A/G cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO -0.42 -6.68 -0.35 1.02e-10 Mean corpuscular volume; CRC cis rs6831352 0.734 rs12502237 chr4:100015675 G/A cg13256891 chr4:100009986 ADH5 0.58 8.1 0.41 1.11e-14 Alcohol dependence; CRC cis rs12477438 0.666 rs10179910 chr2:99658503 A/C cg26064155 chr2:99771622 LIPT1;TSGA10 -0.57 -7.44 -0.38 9.09e-13 Chronic sinus infection; CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg17808901 chr3:39093368 WDR48 -0.5 -6.34 -0.33 7.76e-10 Diisocyanate-induced asthma; CRC cis rs875971 0.862 rs1968126 chr7:66057004 A/G cg18252515 chr7:66147081 NA 0.43 6.14 0.32 2.42e-9 Aortic root size; CRC cis rs72615157 0.561 rs113401658 chr7:99858505 C/T cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.6 6.81 0.35 4.75e-11 Lung function (FEV1/FVC); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg11809094 chr4:159593519 ETFDH;C4orf46 0.46 6.67 0.35 1.07e-10 Intelligence (multi-trait analysis); CRC cis rs6700896 0.931 rs4655743 chr1:66087301 G/C cg04111102 chr1:66153794 NA 0.33 5.94 0.31 7.41e-9 C-reactive protein;Mean corpuscular volume;Mean corpuscular hemoglobin; CRC cis rs9912789 0.744 rs9893755 chr17:79187432 C/T cg25342872 chr17:79175132 AZI1 0.44 7.89 0.4 4.61e-14 Frontotemporal dementia; CRC cis rs7811142 0.830 rs11761253 chr7:99939321 C/T cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.07 14.71 0.63 5.4e-38 Platelet count; CRC cis rs35306767 0.903 rs13377166 chr10:886259 G/A cg26597838 chr10:835615 NA 0.94 11.22 0.53 6.04e-25 Eosinophil percentage of granulocytes; CRC cis rs72634258 1.000 rs72634258 chr1:8150638 T/C cg00042356 chr1:8021962 PARK7 0.72 7.51 0.38 5.59e-13 Inflammatory bowel disease; CRC cis rs457287 0.685 rs466547 chr9:4834034 C/T cg14182974 chr9:4791918 RCL1 -0.41 -6.24 -0.33 1.35e-9 Platelet count; CRC cis rs2180341 0.842 rs6569476 chr6:127553539 G/A cg27446573 chr6:127587934 RNF146 0.87 10.75 0.51 2.69e-23 Breast cancer; CRC cis rs11583043 1.000 rs17100939 chr1:101443701 A/G cg16556008 chr1:101360663 SLC30A7;EXTL2 0.44 5.65 0.3 3.44e-8 Ulcerative colitis;Inflammatory bowel disease; CRC cis rs2742417 0.603 rs1468542 chr3:45779136 A/T cg04837898 chr3:45731254 SACM1L 0.47 7.76 0.39 1.06e-13 Response to anti-depressant treatment in major depressive disorder; CRC cis rs9368481 0.729 rs9379950 chr6:26961548 T/C cg12292205 chr6:26970375 C6orf41 -0.74 -11.92 -0.55 1.85e-27 Autism spectrum disorder or schizophrenia; CRC cis rs68170813 0.559 rs17349904 chr7:106897237 A/C cg02696742 chr7:106810147 HBP1 -0.58 -6.49 -0.34 3.2e-10 Coronary artery disease; CRC cis rs7223966 1.000 rs9909992 chr17:61731931 G/A cg23090583 chr17:61904693 PSMC5;FTSJ3 0.49 6.1 0.32 2.95e-9 Hip circumference adjusted for BMI;Body mass index; CRC trans rs4276421 0.837 rs6451807 chr5:45534423 C/G cg04793272 chr11:119020941 ABCG4 -0.37 -6.07 -0.32 3.48e-9 P wave duration; CRC cis rs10504229 0.728 rs72650860 chr8:58153111 A/G cg22535103 chr8:58192502 C8orf71 -0.68 -8.37 -0.42 1.72e-15 Developmental language disorder (linguistic errors); CRC cis rs300703 0.816 rs449725 chr2:202993 C/G cg21211680 chr2:198530 NA -0.9 -9.45 -0.46 6.64e-19 Blood protein levels; CRC cis rs2346177 0.542 rs1900591 chr2:46697968 C/T cg02822958 chr2:46747628 ATP6V1E2 0.4 5.76 0.3 1.91e-8 HDL cholesterol; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg14360659 chr9:137029702 RNU6ATAC 0.44 6.09 0.32 3.14e-9 Response to antipsychotic treatment; CRC cis rs2204008 0.547 rs12318267 chr12:38250905 T/G cg26384229 chr12:38710491 ALG10B -0.52 -7.49 -0.38 6.21e-13 Bladder cancer; CRC cis rs6662572 0.686 rs72692639 chr1:46446096 A/G cg03123370 chr1:45965343 CCDC163P;MMACHC 0.45 5.64 0.3 3.59e-8 Blood protein levels; CRC cis rs2153535 0.601 rs330105 chr6:8543981 A/C cg21535247 chr6:8435926 SLC35B3 0.51 7.84 0.4 6.25e-14 Motion sickness; CRC cis rs2404602 0.569 rs283793 chr15:76774752 G/A cg03037974 chr15:76606532 NA 0.54 8.05 0.41 1.54e-14 Blood metabolite levels; CRC cis rs6700896 0.966 rs11208689 chr1:66083197 G/A cg04111102 chr1:66153794 NA 0.35 6.21 0.32 1.56e-9 C-reactive protein;Mean corpuscular volume;Mean corpuscular hemoglobin; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg11992992 chr3:71633216 FOXP1 0.45 6.78 0.35 5.61e-11 Liver disease severity in Alagille syndrome; CRC cis rs9354308 0.933 rs12194424 chr6:66574007 T/C cg07460842 chr6:66804631 NA 0.46 5.8 0.3 1.55e-8 Metabolite levels; CRC cis rs1059312 0.808 rs2170989 chr12:129291317 T/C cg23521905 chr12:129298690 SLC15A4;MGC16384 -0.38 -6.57 -0.34 1.97e-10 Systemic lupus erythematosus; CRC cis rs1050631 0.564 rs1785931 chr18:33722107 T/C cg25426722 chr18:33708991 SLC39A6;ELP2 0.37 5.68 0.3 2.96e-8 Esophageal squamous cell cancer (length of survival); CRC cis rs4805272 0.626 rs6509072 chr19:29331703 C/G cg12756686 chr19:29218302 NA 0.47 6.61 0.34 1.51e-10 Plasma omega-3 polyunsaturated fatty acid levels (docosahexaenoic acid); CRC cis rs294883 0.858 rs4709289 chr6:159720529 C/T cg14500486 chr6:159655392 FNDC1 -0.34 -5.63 -0.3 3.89e-8 Coronary artery disease; CRC cis rs2072499 0.695 rs112223391 chr1:156156094 G/A cg24450063 chr1:156163899 SLC25A44 1.05 16.19 0.67 8.71e-44 Testicular germ cell tumor; CRC trans rs783540 0.746 rs7165125 chr15:83297936 C/G cg18393722 chr15:85113863 UBE2QP1 -0.34 -5.97 -0.31 6.24e-9 Schizophrenia; CRC cis rs1552244 1.000 rs56270432 chr3:10087517 G/C cg00166722 chr3:10149974 C3orf24 0.66 9.0 0.44 1.85e-17 Alzheimer's disease; CRC cis rs9322193 0.886 rs2065663 chr6:150081467 A/G cg04369109 chr6:150039330 LATS1 -0.46 -6.13 -0.32 2.56e-9 Lung cancer; CRC cis rs6496667 0.779 rs113212493 chr15:90960293 T/A cg04176472 chr15:90893244 GABARAPL3 0.67 8.31 0.42 2.47e-15 Rheumatoid arthritis; CRC cis rs2279817 1.000 rs1339800 chr1:18020201 C/G cg21791023 chr1:18019539 ARHGEF10L -0.46 -5.89 -0.31 9.51e-9 Neuroticism; CRC cis rs933688 1.000 rs12654787 chr5:90713259 C/T cg26981201 chr5:90679533 LOC100129716;ARRDC3 1.02 15.59 0.65 1.97e-41 Smoking behavior; CRC cis rs11227306 0.934 rs2303385 chr11:65640562 G/A cg26695010 chr11:65641043 EFEMP2 0.44 6.28 0.33 1.05e-9 DNA methylation (variation); CRC cis rs7208859 0.623 rs9914242 chr17:29216245 G/T cg01831904 chr17:28903510 LRRC37B2 -0.6 -5.94 -0.31 7.2e-9 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs780096 0.546 rs1647284 chr2:27608115 C/T cg21248554 chr2:27665150 KRTCAP3 -0.31 -7.14 -0.37 5.9e-12 Total body bone mineral density; CRC cis rs950169 0.920 rs11637666 chr15:84703874 A/G cg17507749 chr15:85114479 UBE2QP1 0.75 10.72 0.51 3.44e-23 Schizophrenia; CRC trans rs7618501 0.966 rs2352974 chr3:49890613 C/T cg21665057 chr3:196295764 WDR53;FBXO45 0.81 14.69 0.63 6.34e-38 Intelligence (multi-trait analysis); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg12820999 chr7:5821320 RNF216 0.45 6.5 0.34 2.94e-10 Response to antipsychotic treatment; CRC cis rs2811415 0.531 rs2116674 chr3:127759664 C/A cg13719885 chr3:127795394 NA -0.36 -5.62 -0.3 4.1e-8 Lung function (FEV1/FVC); CRC cis rs7202877 0.706 rs1540 chr16:75481185 G/C cg03315344 chr16:75512273 CHST6 -0.55 -6.38 -0.33 6.16e-10 Type 2 diabetes;Type 1 diabetes; CRC cis rs9462027 0.628 rs9296129 chr6:34774414 C/G cg07306190 chr6:34760872 UHRF1BP1 0.34 6.19 0.32 1.83e-9 Systemic lupus erythematosus; CRC trans rs7395662 0.500 rs7951327 chr11:48925359 C/T cg15704280 chr7:45808275 SEPT13 -0.52 -7.51 -0.38 5.7e-13 HDL cholesterol; CRC trans rs1005277 0.579 rs2474584 chr10:38416389 C/T cg17830980 chr10:43048298 ZNF37B -0.59 -9.84 -0.48 3.38e-20 Extrinsic epigenetic age acceleration; CRC cis rs1506636 1.000 rs2429619 chr7:123425599 C/G cg03229431 chr7:123269106 ASB15 0.73 11.54 0.54 4.4e-26 Plateletcrit;Platelet count; CRC cis rs11123170 0.640 rs1015754 chr2:113967990 T/C cg21550016 chr2:113992930 PAX8;LOC440839;LOC654433 -0.58 -7.86 -0.4 5.46e-14 Renal function-related traits (BUN); CRC cis rs11711311 0.955 rs67550112 chr3:113401988 C/T cg15478005 chr3:113465772 ATP6V1A;NAA50 0.46 6.24 0.33 1.35e-9 IgG glycosylation; CRC cis rs6748734 0.817 rs10182575 chr2:241806690 C/T cg04034577 chr2:241836375 C2orf54 -0.35 -7.4 -0.38 1.12e-12 Urinary metabolites; CRC cis rs2760061 0.819 rs3094914 chr1:228206934 C/T cg18477163 chr1:228402036 OBSCN 0.42 7.04 0.36 1.13e-11 Diastolic blood pressure; CRC cis rs7666738 0.791 rs34088022 chr4:99001508 G/T cg17366294 chr4:99064904 C4orf37 0.44 7.39 0.38 1.19e-12 Colonoscopy-negative controls vs population controls; CRC cis rs9911578 1.000 rs2531729 chr17:56539890 C/T cg12560992 chr17:57184187 TRIM37 0.9 16.49 0.67 5.75e-45 Intelligence (multi-trait analysis); CRC cis rs9291683 0.530 rs998675 chr4:9948829 A/G cg00071950 chr4:10020882 SLC2A9 0.63 11.25 0.53 4.73e-25 Bone mineral density; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg03901462 chr11:62572874 NXF1 0.46 7.46 0.38 7.7e-13 Liver disease severity in Alagille syndrome; CRC cis rs6461049 0.765 rs3800908 chr7:2159437 C/T cg19897017 chr7:2163380 MAD1L1 0.38 5.74 0.3 2.09e-8 Schizophrenia; CRC cis rs7762018 1.000 rs6904601 chr6:170131905 T/G cg17545662 chr6:170176663 C6orf70 0.57 6.55 0.34 2.26e-10 Thiazide-induced adverse metabolic effects in hypertensive patients; CRC cis rs61008539 0.893 rs4721502 chr7:862186 A/G cg07138768 chr7:917805 C7orf20 0.3 5.81 0.31 1.45e-8 Perceived unattractiveness to mosquitoes; CRC cis rs7208859 0.673 rs9896095 chr17:29187497 A/G cg13385521 chr17:29058706 SUZ12P 0.65 7.73 0.39 1.31e-13 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs2836950 0.501 rs2836983 chr21:40689336 G/A cg17971929 chr21:40555470 PSMG1 -0.52 -7.38 -0.38 1.34e-12 Menarche (age at onset); CRC cis rs514406 0.861 rs35581164 chr1:53271373 C/G cg25767906 chr1:53392781 SCP2 -0.44 -6.89 -0.35 2.9100000000000002e-11 Monocyte count; CRC cis rs7937682 0.855 rs7109592 chr11:111533105 C/A cg19812747 chr11:111475976 SIK2 -0.57 -9.89 -0.48 2.34e-20 Primary sclerosing cholangitis; CRC cis rs2032447 0.839 rs199750 chr6:26016462 A/G cg03517284 chr6:25882590 NA 0.51 7.05 0.36 1.07e-11 Intelligence (multi-trait analysis); CRC cis rs4988958 0.548 rs6543127 chr2:103028301 A/C cg03938978 chr2:103052716 IL18RAP 0.59 10.14 0.49 3.34e-21 Asthma (childhood onset); CRC cis rs1559088 0.948 rs12460195 chr19:33584479 G/A cg27124370 chr19:33622961 WDR88 0.45 6.31 0.33 9.08e-10 Bone ultrasound measurement (broadband ultrasound attenuation); CRC cis rs7666738 0.830 rs13133619 chr4:99067312 C/G cg17366294 chr4:99064904 C4orf37 -0.43 -7.25 -0.37 2.95e-12 Colonoscopy-negative controls vs population controls; CRC trans rs10504229 0.906 rs73607869 chr8:58172665 G/T cg04077850 chr5:125800366 GRAMD3 0.37 6.27 0.33 1.15e-9 Developmental language disorder (linguistic errors); CRC cis rs9326248 0.953 rs634960 chr11:117072963 T/C cg20608306 chr11:116969690 SIK3 -0.3 -5.61 -0.3 4.26e-8 Blood protein levels; CRC cis rs2228479 0.850 rs12598276 chr16:89829196 G/C cg06558623 chr16:89946397 TCF25 1.13 10.45 0.5 2.85e-22 Skin colour saturation; CRC cis rs12824058 0.831 rs4759451 chr12:130812739 G/A cg26677194 chr12:130822605 PIWIL1 0.45 7.18 0.37 4.53e-12 Menopause (age at onset); CRC cis rs4713118 0.513 rs149958 chr6:28013617 A/C cg18032046 chr6:28092343 ZSCAN16 -0.44 -5.94 -0.31 7.37e-9 Parkinson's disease; CRC cis rs201673768 1 rs201673768 chr12:48699606 TGTTTTGTTTTG/T cg21466736 chr12:48725269 NA -0.52 -8.08 -0.41 1.23e-14 Platelet count; CRC cis rs34779708 0.931 rs10466072 chr10:35402756 C/T cg03585969 chr10:35415529 CREM 0.59 7.97 0.4 2.56e-14 Inflammatory bowel disease;Crohn's disease; CRC cis rs6089584 0.830 rs4925331 chr20:60580174 T/C cg18761221 chr20:60518478 NA 0.39 6.87 0.35 3.19e-11 Body mass index; CRC cis rs9491140 0.539 rs10872284 chr6:124685928 G/A cg05308643 chr6:124982296 NKAIN2 0.48 6.64 0.34 1.26e-10 Neuroticism; CRC cis rs4363385 0.818 rs435633 chr1:153011811 A/G cg25856811 chr1:152973957 SPRR3 -0.25 -6.99 -0.36 1.51e-11 Inflammatory skin disease; CRC cis rs2108225 0.900 rs4518594 chr7:107451060 G/C cg18560240 chr7:107437656 SLC26A3 -0.6 -9.42 -0.46 8.47e-19 Ulcerative colitis; CRC cis rs453301 0.658 rs9329175 chr8:8866661 C/T cg14979609 chr8:8086686 FLJ10661 0.35 5.7 0.3 2.68e-8 Joint mobility (Beighton score); CRC cis rs13256369 1.000 rs13282915 chr8:8570891 T/G cg18904891 chr8:8559673 CLDN23 0.51 6.85 0.35 3.65e-11 Obesity-related traits; CRC cis rs10540 1.000 rs116101630 chr11:506826 G/C cg03352830 chr11:487213 PTDSS2 0.63 7.24 0.37 3.25e-12 Body mass index; CRC cis rs754466 0.580 rs11002301 chr10:79574078 G/A cg26805224 chr10:79626177 DLG5 -0.49 -7.29 -0.37 2.37e-12 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs3858526 0.796 rs9645652 chr11:5944264 C/T cg05234568 chr11:5960015 NA -0.53 -7.24 -0.37 3.19e-12 DNA methylation (variation); CRC cis rs9527 0.590 rs1046411 chr10:104837816 G/A cg15744005 chr10:104629667 AS3MT -0.29 -5.8 -0.3 1.55e-8 Arsenic metabolism; CRC cis rs6964587 0.541 rs6947170 chr7:91451471 A/G cg17063962 chr7:91808500 NA 0.57 8.83 0.44 6.39e-17 Breast cancer; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg01623627 chr12:56473229 ERBB3 0.39 6.25 0.33 1.3e-9 Liver disease severity in Alagille syndrome; CRC cis rs881375 0.967 rs7848332 chr9:123669496 T/C cg00246817 chr9:123691163 NA -0.47 -6.04 -0.32 4.11e-9 Rheumatoid arthritis; CRC cis rs7618915 0.524 rs10433615 chr3:52638482 C/T cg10802521 chr3:52805072 NEK4 -0.59 -9.1 -0.45 8.89e-18 Bipolar disorder; CRC cis rs6089584 0.566 rs7274240 chr20:60622004 C/T cg23262073 chr20:60523788 NA -0.39 -6.34 -0.33 7.37e-10 Body mass index; CRC cis rs1707322 0.717 rs28752166 chr1:46213309 G/A cg03146154 chr1:46216737 IPP 0.68 9.85 0.48 3.13e-20 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg16909824 chr1:151299438 PI4KB 0.48 6.8 0.35 4.87e-11 Response to antipsychotic treatment; CRC cis rs6951245 1.000 rs11768761 chr7:1069807 A/G cg26224354 chr7:1096374 C7orf50;GPR146 -0.88 -11.08 -0.52 1.89e-24 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs7224685 0.501 rs781850 chr17:3957124 C/T cg09695851 chr17:3907499 NA -0.78 -14.33 -0.62 1.65e-36 Type 2 diabetes; CRC cis rs13256369 1.000 rs883648 chr8:8569521 A/G cg00074818 chr8:8560427 CLDN23 0.41 7.54 0.38 4.61e-13 Obesity-related traits; CRC cis rs7914558 1.000 rs943038 chr10:104826261 T/C cg15744005 chr10:104629667 AS3MT -0.33 -7.11 -0.36 7.49e-12 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs7615952 0.641 rs2365019 chr3:125808135 T/C cg02772935 chr3:125709198 NA -0.5 -5.81 -0.3 1.5e-8 Blood pressure (smoking interaction); CRC cis rs875971 0.545 rs73148639 chr7:65855329 A/T cg18876405 chr7:65276391 NA 0.45 6.35 0.33 7.13e-10 Aortic root size; CRC cis rs6951245 1.000 rs11767527 chr7:1097394 T/C cg22907277 chr7:1156413 C7orf50 0.73 7.68 0.39 1.78e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs8062405 1.000 rs62036626 chr16:28844284 A/G cg16576597 chr16:28551801 NUPR1 0.48 6.9 0.36 2.65e-11 Cognitive ability (multi-trait analysis);Cognitive ability; CRC cis rs7178572 0.633 rs4886875 chr15:77838419 C/T cg22256960 chr15:77711686 NA 0.64 9.39 0.46 1.04e-18 Type 2 diabetes; CRC cis rs2635047 0.967 rs2684843 chr18:44726260 T/A cg19077165 chr18:44547161 KATNAL2 -0.46 -7.49 -0.38 6.6e-13 Educational attainment; CRC cis rs1707322 0.721 rs10890341 chr1:46147240 C/A cg06784218 chr1:46089804 CCDC17 0.65 12.18 0.56 2e-28 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs9902453 0.967 rs4533341 chr17:28495672 T/G cg26525008 chr17:28256777 EFCAB5;SSH2 0.55 8.3 0.42 2.76e-15 Coffee consumption (cups per day); CRC cis rs4728302 0.574 rs7804463 chr7:133447651 T/C cg10665199 chr7:133106180 EXOC4 0.44 6.92 0.36 2.35e-11 Intelligence;Intelligence (multi-trait analysis); CRC cis rs7937682 0.883 rs542831 chr11:111471392 T/A cg19812747 chr11:111475976 SIK2 -0.57 -9.63 -0.47 1.69e-19 Primary sclerosing cholangitis; CRC cis rs7647973 0.516 rs4955419 chr3:49200692 T/A cg07636037 chr3:49044803 WDR6 0.84 13.11 0.59 7.23e-32 Menarche (age at onset); CRC cis rs9308731 0.623 rs11674517 chr2:111903832 C/T cg18646521 chr2:111875858 NA 0.4 6.36 0.33 6.66e-10 Chronic lymphocytic leukemia; CRC cis rs796364 1.000 rs281785 chr2:200749566 A/G cg12253985 chr2:200820533 C2orf60;C2orf47 0.6 6.68 0.35 1.02e-10 Schizophrenia; CRC cis rs12893668 0.542 rs12884809 chr14:104095320 G/A cg24130564 chr14:104152367 KLC1 -0.47 -6.45 -0.34 3.88e-10 Reticulocyte count; CRC cis rs6951245 0.572 rs73264010 chr7:1040477 T/C cg26224354 chr7:1096374 C7orf50;GPR146 -0.83 -7.87 -0.4 5.31e-14 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs9462027 0.606 rs7759227 chr6:34728230 C/G cg07306190 chr6:34760872 UHRF1BP1 -0.35 -6.24 -0.33 1.36e-9 Systemic lupus erythematosus; CRC trans rs11098499 0.955 rs13129661 chr4:120152909 C/G cg25214090 chr10:38739885 LOC399744 0.5 7.64 0.39 2.38e-13 Corneal astigmatism; CRC trans rs208520 0.690 rs851464 chr6:66839802 C/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.08 -14.9 -0.63 9.49e-39 Exhaled nitric oxide output; CRC cis rs758324 0.947 rs72793241 chr5:131240885 C/T cg06307176 chr5:131281290 NA -0.41 -6.02 -0.32 4.64e-9 Alzheimer's disease in APOE e4- carriers; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg19183932 chr6:27791712 HIST1H4J 0.48 7.46 0.38 7.74e-13 Liver disease severity in Alagille syndrome; CRC cis rs3768617 0.811 rs6424883 chr1:183037695 T/C ch.1.3577855R chr1:183094577 LAMC1 0.64 9.41 0.46 8.79e-19 Fuchs's corneal dystrophy; CRC cis rs1005277 0.579 rs176886 chr10:38403974 C/T cg25427524 chr10:38739819 LOC399744 -0.77 -13.65 -0.6 6.24e-34 Extrinsic epigenetic age acceleration; CRC cis rs35110281 0.744 rs230646 chr21:44918788 A/G cg04455712 chr21:45112962 RRP1B 0.4 7.52 0.38 5.22e-13 Mean corpuscular volume; CRC cis rs9400239 0.584 rs1268174 chr6:109018859 A/G cg11073813 chr6:109029018 NA -0.38 -5.99 -0.31 5.61e-9 Waist circumference;Body mass index;BMI (adjusted for smoking behaviour); CRC trans rs6550704 0.687 rs9865314 chr3:22634337 A/G cg14616479 chr3:155588124 GMPS -0.41 -6.01 -0.31 5e-9 Daytime sleep phenotypes; CRC cis rs8180040 0.653 rs6808742 chr3:47051512 G/A cg27129171 chr3:47204927 SETD2 0.69 11.11 0.52 1.49e-24 Colorectal cancer; CRC cis rs6502050 0.799 rs9675196 chr17:80096655 C/T cg13198984 chr17:80129470 CCDC57 0.48 8.45 0.42 9.35e-16 Life satisfaction; CRC cis rs2120019 1.000 rs12903201 chr15:75370776 A/C cg17294928 chr15:75287854 SCAMP5 -0.73 -10.92 -0.52 6.61e-24 Blood trace element (Zn levels); CRC cis rs7224685 0.648 rs12453576 chr17:3881293 C/T cg05562828 chr17:3906858 NA 0.49 6.18 0.32 1.92e-9 Type 2 diabetes; CRC cis rs2153535 0.580 rs2184582 chr6:8447793 G/A cg21535247 chr6:8435926 SLC35B3 0.5 7.5 0.38 6.06e-13 Motion sickness; CRC cis rs7811142 1.000 rs7811142 chr7:100065443 A/T cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.19 17.58 0.7 2.92e-49 Platelet count; CRC cis rs1448094 0.511 rs61930582 chr12:86157387 T/C cg25456477 chr12:86230367 RASSF9 0.39 6.45 0.34 3.89e-10 Major depressive disorder; CRC cis rs2019137 0.560 rs7421852 chr2:113990261 G/A cg09704166 chr2:114031854 PAX8;LOC440839 -0.38 -7.11 -0.36 7.47e-12 Lymphocyte counts; CRC cis rs13064411 0.696 rs36054418 chr3:113204762 G/T cg18753928 chr3:113234510 CCDC52 -0.7 -10.83 -0.51 1.45e-23 Response to simvastatin treatment (PCSK9 protein level change); CRC cis rs10888329 0.819 rs4546956 chr1:248358953 G/A cg00666640 chr1:248458726 OR2T12 0.44 7.07 0.36 9.39e-12 Autism spectrum disorder; CRC cis rs728616 0.681 rs35014047 chr10:81912397 A/C cg11900509 chr10:81946545 ANXA11 -0.72 -8.54 -0.43 4.91e-16 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs7539542 0.556 rs1539357 chr1:202878454 T/A cg19681188 chr1:202830198 LOC148709 0.46 6.55 0.34 2.18e-10 Mean platelet volume; CRC cis rs1975031 1 rs1975031 chr19:7217601 G/A cg00428638 chr19:7224713 INSR -0.79 -9.94 -0.48 1.62e-20 Perceived unattractiveness to mosquitoes; CRC cis rs7659604 1.000 rs6816071 chr4:122665185 G/A cg06713675 chr4:122721982 EXOSC9 -0.39 -6.38 -0.33 6.01e-10 Type 2 diabetes; CRC cis rs3733585 0.699 rs6449176 chr4:9967843 G/A cg11266682 chr4:10021025 SLC2A9 -0.47 -9.55 -0.47 3.01e-19 Cleft plate (environmental tobacco smoke interaction); CRC cis rs1881797 0.872 rs12408686 chr1:247691141 C/T cg11166453 chr1:247681781 NA 0.44 7.04 0.36 1.1e-11 Acute lymphoblastic leukemia (childhood); CRC trans rs1814175 0.935 rs11040462 chr11:49683158 G/A cg03929089 chr4:120376271 NA -0.94 -17.19 -0.69 1.07e-47 Height; CRC cis rs67311347 1.000 rs6599094 chr3:40399593 A/G cg09455208 chr3:40491958 NA 0.43 8.67 0.43 2.01e-16 Renal cell carcinoma; CRC trans rs17685 0.632 rs1859793 chr7:75821283 G/A cg19862616 chr7:65841803 NCRNA00174 0.92 15.72 0.65 6.46e-42 Coffee consumption;Coffee consumption (cups per day); CRC cis rs10992471 0.535 rs10117041 chr9:95282331 A/G cg14631576 chr9:95140430 CENPP -0.39 -6.77 -0.35 5.99e-11 Visceral adipose tissue/subcutaneous adipose tissue ratio; CRC cis rs6942756 1.000 rs6974155 chr7:128914545 C/G cg02491457 chr7:128862824 NA -0.76 -10.29 -0.49 1.06e-21 White matter hyperintensity burden; CRC cis rs9611565 0.694 rs7285041 chr22:41829149 G/T cg06634786 chr22:41940651 POLR3H 0.72 8.0 0.4 2.21e-14 Vitiligo; CRC cis rs6938 0.534 rs1133322 chr15:75212357 A/G cg18612461 chr15:75251733 NA 0.38 5.92 0.31 7.95e-9 Breast cancer; CRC cis rs7677751 0.806 rs67432867 chr4:55104454 A/T cg00691999 chr4:55094011 PDGFRA 0.4 5.93 0.31 7.46e-9 Corneal astigmatism; CRC cis rs2075371 0.931 rs1646697 chr7:133999930 G/A cg11752832 chr7:134001865 SLC35B4 0.5 7.63 0.39 2.52e-13 Mean platelet volume; CRC cis rs57221529 0.713 rs72703072 chr5:590626 A/G cg14541582 chr5:601475 NA -0.36 -7.11 -0.36 7.3e-12 Lung disease severity in cystic fibrosis; CRC cis rs950169 0.580 rs11630887 chr15:85193015 A/T cg11189052 chr15:85197271 WDR73 0.65 9.53 0.47 3.47e-19 Schizophrenia; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg06417831 chr6:43596987 MAD2L1BP;GTPBP2 0.45 6.01 0.31 5.04e-9 Anxiety disorder; CRC cis rs875971 0.545 rs316323 chr7:65610989 C/T cg03233332 chr7:66118400 NA 0.45 6.24 0.33 1.36e-9 Aortic root size; CRC cis rs13082711 0.911 rs997680 chr3:27443638 G/A cg02860705 chr3:27208620 NA 0.59 8.48 0.42 7.66e-16 Systolic blood pressure;Diastolic blood pressure;Blood pressure; CRC cis rs7927771 0.894 rs12798346 chr11:47583121 C/T cg20307385 chr11:47447363 PSMC3 -0.55 -7.75 -0.39 1.19e-13 Subjective well-being; CRC cis rs1757171 0.534 rs2797793 chr6:37477262 C/T cg01843034 chr6:37503916 NA 0.38 6.31 0.33 9.05e-10 Cognitive performance; CRC cis rs2180341 0.883 rs9388568 chr6:127690694 C/A cg27446573 chr6:127587934 RNF146 0.94 13.54 0.6 1.62e-33 Breast cancer; CRC cis rs853679 1.000 rs10456362 chr6:28221816 A/G cg15786705 chr6:28176104 NA -0.56 -6.08 -0.32 3.38e-9 Depression; CRC cis rs11098499 0.955 rs13114751 chr4:120156617 G/A cg24375607 chr4:120327624 NA 0.44 6.83 0.35 4.17e-11 Corneal astigmatism; CRC trans rs4942242 0.640 rs17538959 chr13:44229911 T/G cg19169023 chr15:41853346 TYRO3 -0.64 -9.05 -0.45 1.24e-17 Response to tocilizumab in rheumatoid arthritis; CRC cis rs2153535 0.580 rs9393023 chr6:8469994 T/G cg21535247 chr6:8435926 SLC35B3 0.49 7.4 0.38 1.14e-12 Motion sickness; CRC cis rs7119 0.689 rs8040318 chr15:77803660 A/C cg10437265 chr15:77819839 NA 0.6 10.69 0.51 4.18e-23 Type 2 diabetes; CRC cis rs7726839 0.794 rs10474792 chr5:600058 G/A cg16035780 chr5:759353 NA 0.36 5.75 0.3 2.03e-8 Obesity-related traits; CRC cis rs6500395 0.735 rs16946340 chr16:48667717 G/A cg04672837 chr16:48644449 N4BP1 0.43 6.26 0.33 1.18e-9 Response to tocilizumab in rheumatoid arthritis; CRC cis rs6968419 0.674 rs17138528 chr7:115907289 T/C cg02561103 chr7:115862891 TES -0.42 -6.22 -0.32 1.48e-9 Intraocular pressure; CRC cis rs11122272 0.735 rs2572252 chr1:231513653 T/C cg06096015 chr1:231504339 EGLN1 0.4 5.95 0.31 6.7e-9 Hemoglobin concentration; CRC cis rs362272 0.505 rs13104157 chr4:3366950 T/C cg01612440 chr4:3296283 NA 0.43 6.03 0.32 4.4e-9 Serum sulfate level; CRC cis rs7849270 0.851 rs7861663 chr9:131880946 G/A cg13538475 chr9:131942899 NA -0.29 -5.89 -0.31 9.75e-9 Blood metabolite ratios; CRC cis rs10256972 0.521 rs7457418 chr7:1110255 C/T cg04025307 chr7:1156635 C7orf50 0.46 6.87 0.35 3.17e-11 Longevity;Endometriosis; CRC cis rs6545883 0.965 rs10186325 chr2:61757721 G/T cg15711740 chr2:61764176 XPO1 -0.53 -7.26 -0.37 2.88e-12 Tuberculosis; CRC cis rs9463078 0.790 rs1324531 chr6:45136224 T/C cg25276700 chr6:44698697 NA -0.28 -6.71 -0.35 8.36e-11 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; CRC cis rs1048238 0.506 rs848209 chr1:16256007 T/C cg21385522 chr1:16154831 NA -0.63 -9.07 -0.45 1.08e-17 Systolic blood pressure; CRC cis rs9462027 0.628 rs2395604 chr6:34787976 A/C cg07306190 chr6:34760872 UHRF1BP1 -0.35 -6.17 -0.32 2e-9 Systemic lupus erythematosus; CRC trans rs1973993 0.967 rs6679458 chr1:96946253 G/T cg10631902 chr5:14652156 NA 0.49 8.59 0.43 3.6e-16 Weight; CRC cis rs921968 0.565 rs6733892 chr2:219616002 C/A cg02176678 chr2:219576539 TTLL4 -0.44 -7.34 -0.37 1.73e-12 Mean corpuscular hemoglobin concentration; CRC cis rs2976388 0.566 rs2585146 chr8:143798641 A/C cg04969067 chr8:143858791 LYNX1 0.43 6.58 0.34 1.84e-10 Urinary tract infection frequency; CRC cis rs10504229 1.000 rs67630725 chr8:58185580 G/A cg24829409 chr8:58192753 C8orf71 -0.68 -11.34 -0.53 2.27e-25 Developmental language disorder (linguistic errors); CRC trans rs11098499 0.909 rs11723839 chr4:120299673 G/A cg25214090 chr10:38739885 LOC399744 0.63 9.85 0.48 3.18e-20 Corneal astigmatism; CRC cis rs425277 1.000 rs1401138 chr1:2063149 C/T cg24578937 chr1:2090814 PRKCZ 0.67 11.83 0.55 3.91e-27 Height; CRC trans rs2407314 0.595 rs10094300 chr8:4087295 C/T cg01356198 chr3:187929513 LPP -0.39 -6.08 -0.32 3.33e-9 Insulin resistance/response; CRC trans rs1656966 1.000 rs1656966 chr3:186466252 C/T cg13791713 chr21:40720916 HMGN1 0.41 6.25 0.33 1.28e-9 Myopia (pathological); CRC cis rs2932538 0.885 rs6691025 chr1:113177070 G/T cg22162597 chr1:113214053 CAPZA1 -0.74 -10.46 -0.5 2.76e-22 Systolic blood pressure;Diastolic blood pressure;Hypertension;Blood pressure; CRC cis rs2153535 0.580 rs4140586 chr6:8503192 A/G cg21535247 chr6:8435926 SLC35B3 0.48 7.36 0.38 1.49e-12 Motion sickness; CRC cis rs1580019 0.587 rs6968990 chr7:32552159 C/T cg06627557 chr7:32535165 LSM5;AVL9 -0.92 -17.68 -0.7 1.24e-49 Cognitive ability; CRC cis rs6460942 1.000 rs62448565 chr7:12400458 G/A cg20607287 chr7:12443886 VWDE -0.67 -6.68 -0.35 1.01e-10 Coronary artery disease; CRC cis rs7246657 1.000 rs6508710 chr19:37749886 A/G cg23950597 chr19:37808831 NA -0.48 -5.78 -0.3 1.77e-8 Coronary artery calcification; CRC cis rs2971970 0.519 rs2346272 chr7:133654830 T/C cg03336402 chr7:133662267 EXOC4 -0.67 -10.43 -0.5 3.51e-22 Intelligence (multi-trait analysis); CRC cis rs597539 0.652 rs482172 chr11:68668437 C/A cg06112835 chr11:68658793 MRPL21 0.48 7.67 0.39 2e-13 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC trans rs12310956 0.532 rs11052954 chr12:33993512 C/G cg26384229 chr12:38710491 ALG10B 0.47 6.22 0.32 1.47e-9 Morning vs. evening chronotype; CRC cis rs477692 0.789 rs568166 chr10:131400088 G/A cg05714579 chr10:131428358 MGMT 0.54 7.6 0.39 3.15e-13 Response to temozolomide; CRC cis rs524281 0.817 rs10791859 chr11:65978453 C/T cg16950941 chr11:66035639 RAB1B -0.66 -7.87 -0.4 5.28e-14 Electroencephalogram traits; CRC cis rs853679 1.000 rs853679 chr6:28296863 C/A cg06470822 chr6:28175283 NA 0.59 6.14 0.32 2.39e-9 Depression; CRC cis rs13118159 0.550 rs4974611 chr4:1358449 T/C cg20887711 chr4:1340912 KIAA1530 0.75 10.86 0.51 1.12e-23 Longevity; CRC cis rs2070488 0.965 rs13079145 chr3:38517992 T/G cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.92 17.17 0.69 1.2e-47 Electrocardiographic conduction measures; CRC cis rs2019137 0.967 rs895412 chr2:113973964 T/C cg21482265 chr2:113992762 PAX8;LOC440839;LOC654433 -0.47 -6.67 -0.35 1.07e-10 Lymphocyte counts; CRC cis rs9443645 0.775 rs9359359 chr6:79700980 T/C cg05283184 chr6:79620031 NA -0.56 -8.6 -0.43 3.34e-16 Intelligence (multi-trait analysis); CRC cis rs2832077 0.527 rs59730679 chr21:30226244 T/C cg24692254 chr21:30365293 RNF160 -0.45 -6.7 -0.35 9.28e-11 Cognitive test performance; CRC cis rs7666738 0.927 rs11736876 chr4:98987206 A/G cg05340658 chr4:99064831 C4orf37 0.51 7.22 0.37 3.6e-12 Colonoscopy-negative controls vs population controls; CRC cis rs1862618 0.853 rs252915 chr5:56121754 C/T cg12311346 chr5:56204834 C5orf35 0.7 9.33 0.46 1.65e-18 Initial pursuit acceleration; CRC cis rs2929278 0.617 rs663214 chr15:44113782 T/G cg02155558 chr15:43621948 ADAL;LCMT2 -0.48 -6.85 -0.35 3.57e-11 Schizophrenia; CRC cis rs7605827 0.626 rs2031011 chr2:15548390 A/G cg19274914 chr2:15703543 NA 0.38 5.65 0.3 3.56e-8 Educational attainment (years of education); CRC cis rs6909279 0.648 rs6919923 chr6:151849670 T/C cg10883421 chr6:151773342 RMND1;C6orf211 -0.44 -6.69 -0.35 9.69e-11 Bone mineral density; CRC cis rs6835098 0.828 rs28612521 chr4:174085294 G/A cg08422745 chr4:174089978 GALNT7 -0.96 -16.27 -0.67 4.46e-44 Dementia and core Alzheimer's disease neuropathologic changes; CRC cis rs6952808 0.723 rs60432611 chr7:2029629 G/C cg04267008 chr7:1944627 MAD1L1 -0.78 -11.33 -0.53 2.45e-25 Bipolar disorder and schizophrenia; CRC cis rs274567 0.501 rs2631368 chr5:131705297 T/G cg02033258 chr5:131593261 PDLIM4 -0.39 -6.76 -0.35 6.12e-11 Blood metabolite levels; CRC cis rs13108904 0.967 rs4642180 chr4:1278914 T/C cg19318889 chr4:1322082 MAEA 0.4 5.65 0.3 3.41e-8 Obesity-related traits; CRC cis rs7618501 0.521 rs2883059 chr3:49902160 C/T cg21467203 chr3:49911342 NA 0.24 5.93 0.31 7.77e-9 Intelligence (multi-trait analysis); CRC cis rs7843479 0.601 rs10866827 chr8:21801141 G/A cg16476235 chr8:21771668 DOK2 0.37 6.22 0.32 1.48e-9 Mean corpuscular volume; CRC cis rs4713118 0.955 rs9468201 chr6:27687035 C/T cg06470822 chr6:28175283 NA 0.67 9.13 0.45 6.85e-18 Parkinson's disease; CRC cis rs12497850 0.931 rs9835307 chr3:48857805 T/C cg07636037 chr3:49044803 WDR6 1.03 18.15 0.71 1.69e-51 Parkinson's disease; CRC cis rs2477686 0.526 rs1998759 chr1:2397174 C/T cg02850689 chr1:2391347 NA -0.39 -6.4 -0.33 5.22e-10 Non-obstructive azoospermia; CRC cis rs753778 0.570 rs4961335 chr8:142209142 A/G cg18755752 chr8:142205143 DENND3 -0.61 -10.29 -0.49 1.06e-21 Reticulocyte fraction of red cells;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; CRC cis rs11229555 0.645 rs11229431 chr11:58181253 A/G cg15696309 chr11:58395628 NA -0.81 -10.31 -0.49 8.83e-22 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; CRC cis rs2180341 0.960 rs7766942 chr6:127691323 G/T cg24812749 chr6:127587940 RNF146 0.92 13.17 0.59 4.28e-32 Breast cancer; CRC cis rs780096 0.546 rs1060525 chr2:27635582 A/G cg12000995 chr2:27665139 KRTCAP3 -0.29 -6.19 -0.32 1.81e-9 Total body bone mineral density; CRC cis rs4665809 0.549 rs62130460 chr2:26472718 T/C cg25036284 chr2:26402008 FAM59B 0.68 8.3 0.42 2.76e-15 Gut microbiome composition (summer); CRC cis rs637571 0.676 rs634534 chr11:65665256 A/G cg26695010 chr11:65641043 EFEMP2 0.46 6.82 0.35 4.43e-11 Eosinophil percentage of white cells; CRC cis rs6951245 1.000 rs80094748 chr7:1103958 G/A cg20603222 chr7:1096387 C7orf50;GPR146 -0.73 -8.7 -0.43 1.62e-16 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs1862618 0.853 rs861283 chr5:56184610 C/T cg12311346 chr5:56204834 C5orf35 -0.79 -10.04 -0.48 7.48e-21 Initial pursuit acceleration; CRC cis rs9818758 0.607 rs9880088 chr3:49178990 G/A cg07636037 chr3:49044803 WDR6 -0.7 -5.91 -0.31 8.32e-9 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; CRC cis rs875971 1.000 rs7783613 chr7:65805261 C/T cg12463550 chr7:65579703 CRCP -0.5 -7.21 -0.37 3.91e-12 Aortic root size; CRC cis rs10464366 0.544 rs4540324 chr7:39185299 G/C cg20302533 chr7:39170763 POU6F2 0.41 5.66 0.3 3.38e-8 IgG glycosylation; CRC cis rs977987 0.806 rs4888383 chr16:75386349 C/T cg03315344 chr16:75512273 CHST6 0.52 8.8 0.44 7.68e-17 Dupuytren's disease; CRC cis rs9948 0.655 rs62156213 chr2:97399100 T/C cg20312557 chr2:97357134 FER1L5 -0.6 -5.61 -0.3 4.38e-8 Erectile dysfunction and prostate cancer treatment; CRC cis rs7605827 0.930 rs4668925 chr2:15703576 C/T cg19274914 chr2:15703543 NA 0.39 5.95 0.31 6.79e-9 Educational attainment (years of education); CRC cis rs875971 1.000 rs1363055 chr7:65943275 A/G cg18876405 chr7:65276391 NA 0.52 8.85 0.44 5.32e-17 Aortic root size; CRC cis rs6570726 0.577 rs399502 chr6:145805874 A/G cg23711669 chr6:146136114 FBXO30 0.61 9.1 0.45 8.91e-18 Lobe attachment (rater-scored or self-reported); CRC cis rs1403694 0.695 rs1851665 chr3:186436398 A/G cg04611788 chr3:186434169 KNG1 -0.59 -8.78 -0.44 8.92e-17 Blood protein levels; CRC cis rs12476592 0.602 rs1255 chr2:63825934 T/C cg10828910 chr2:63850056 LOC388955 0.5 6.13 0.32 2.54e-9 Childhood ear infection; CRC cis rs7607369 0.580 rs7594289 chr2:219652286 A/G cg02176678 chr2:219576539 TTLL4 -0.56 -9.01 -0.44 1.76e-17 Red blood cell count;Amyotrophic lateral sclerosis; CRC cis rs6502050 0.765 rs6502075 chr17:80121813 G/A cg25804541 chr17:80189381 SLC16A3 -0.31 -5.95 -0.31 6.83e-9 Life satisfaction; CRC cis rs17401966 0.838 rs12127604 chr1:10352800 T/G cg19773385 chr1:10388646 KIF1B -0.67 -10.99 -0.52 3.83e-24 Hepatocellular carcinoma; CRC cis rs7192380 0.893 rs12921782 chr16:69780022 C/T cg00738113 chr16:70207722 CLEC18C 0.37 6.43 0.33 4.4e-10 Sjögren's syndrome; CRC cis rs891088 0.622 rs11670932 chr19:7206790 A/G cg09779027 chr19:7224513 INSR -0.62 -7.54 -0.38 4.72e-13 Hip circumference adjusted for BMI;Height; CRC cis rs1005277 0.522 rs11011343 chr10:38002698 A/G cg00409905 chr10:38381863 ZNF37A -0.64 -10.52 -0.5 1.73e-22 Extrinsic epigenetic age acceleration; CRC trans rs1590305 0.786 rs61946576 chr13:38060134 T/C cg03965764 chr11:45248109 NA -0.6 -6.15 -0.32 2.31e-9 Hip geometry; CRC cis rs6062302 0.522 rs13043255 chr20:62218916 C/G cg09650180 chr20:62225654 GMEB2 -0.52 -6.91 -0.36 2.51e-11 Glioblastoma; CRC trans rs10504390 0.656 rs17394294 chr8:66512767 T/C cg26403416 chr21:43771339 TFF2 0.6 6.22 0.32 1.47e-9 IgG glycosylation; CRC cis rs9322193 0.962 rs3805749 chr6:150093682 C/T cg07701084 chr6:150067640 NUP43 0.58 7.94 0.4 3.29e-14 Lung cancer; CRC cis rs4363385 0.818 rs426360 chr1:153014710 C/T cg25856811 chr1:152973957 SPRR3 -0.26 -7.17 -0.37 4.93e-12 Inflammatory skin disease; CRC cis rs2625529 0.689 rs8178 chr15:72114747 G/A cg16672083 chr15:72433130 SENP8 -0.45 -6.54 -0.34 2.38e-10 Red blood cell count; CRC cis rs16852403 0.517 rs1319918 chr1:178243524 A/G cg00404053 chr1:178313656 RASAL2 0.48 6.12 0.32 2.7e-9 Childhood ear infection; CRC cis rs8114671 0.551 rs4911162 chr20:33411425 G/C cg24642439 chr20:33292090 TP53INP2 0.36 5.88 0.31 1.03e-8 Height; CRC cis rs1862618 0.853 rs6450409 chr5:56101399 A/G cg20203395 chr5:56204925 C5orf35 -0.58 -6.86 -0.35 3.42e-11 Initial pursuit acceleration; CRC trans rs11098499 0.754 rs12711071 chr4:120240934 A/G cg25214090 chr10:38739885 LOC399744 0.55 8.5 0.42 6.5e-16 Corneal astigmatism; CRC cis rs9457247 1.000 rs385863 chr6:167386615 C/G cg23791538 chr6:167370224 RNASET2 -0.38 -5.97 -0.31 6.08e-9 Crohn's disease; CRC cis rs13256369 1.000 rs12550762 chr8:8576535 T/A cg06636001 chr8:8085503 FLJ10661 0.44 5.77 0.3 1.86e-8 Obesity-related traits; CRC cis rs2439831 0.867 rs11856184 chr15:43919162 A/C cg02155558 chr15:43621948 ADAL;LCMT2 0.67 7.51 0.38 5.67e-13 Lung cancer in ever smokers; CRC cis rs10256972 0.553 rs4236381 chr7:1165723 A/C cg07308232 chr7:1071921 C7orf50 -0.47 -6.26 -0.33 1.22e-9 Longevity;Endometriosis; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg07754938 chr3:48885314 PRKAR2A 0.42 6.19 0.32 1.77e-9 Intelligence (multi-trait analysis); CRC cis rs780096 0.526 rs809058 chr2:27616790 T/C cg22903471 chr2:27725779 GCKR -0.37 -6.09 -0.32 3.1e-9 Total body bone mineral density; CRC cis rs3733585 0.638 rs7377625 chr4:9953099 T/C cg00071950 chr4:10020882 SLC2A9 -0.55 -9.83 -0.48 3.67e-20 Cleft plate (environmental tobacco smoke interaction); CRC cis rs4713118 0.869 rs2056925 chr6:27690905 A/G cg25164649 chr6:28176230 NA 0.58 8.04 0.41 1.65e-14 Parkinson's disease; CRC trans rs7819412 0.645 rs10156356 chr8:11046209 T/C cg06636001 chr8:8085503 FLJ10661 -0.51 -7.76 -0.39 1.08e-13 Triglycerides; CRC cis rs6988985 0.728 rs56400819 chr8:143925374 A/G cg10324643 chr8:143916377 GML 0.35 5.67 0.3 3.16e-8 Plasma androstenedione levels in resected early stage-receptor positive breast cancer; CRC cis rs2070488 0.930 rs928813 chr3:38528537 G/T cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.93 17.32 0.69 3.19e-48 Electrocardiographic conduction measures; CRC cis rs7202877 0.706 rs37599 chr16:75502132 C/T cg03315344 chr16:75512273 CHST6 -0.56 -6.64 -0.34 1.3100000000000001e-10 Type 2 diabetes;Type 1 diabetes; CRC cis rs2806561 0.704 rs1757039 chr1:23508657 A/G cg12483005 chr1:23474871 LUZP1 0.5 7.27 0.37 2.58e-12 Height; CRC cis rs798554 0.567 rs1182192 chr7:2869274 G/A cg13628971 chr7:2884303 GNA12 0.4 6.27 0.33 1.14e-9 Height; CRC cis rs727479 0.502 rs2899471 chr15:51506553 G/A cg19946085 chr15:51559439 CYP19A1 -0.3 -6.08 -0.32 3.36e-9 Estradiol levels; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg25946952 chr7:143059218 FAM131B 0.38 6.39 0.33 5.65e-10 Liver disease severity in Alagille syndrome; CRC cis rs1008375 1.000 rs7659718 chr4:17638020 A/C cg04450456 chr4:17643702 FAM184B 0.36 5.69 0.3 2.82e-8 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs9611565 0.559 rs739136 chr22:42100275 C/T cg06481639 chr22:41940642 POLR3H -0.55 -6.27 -0.33 1.15e-9 Vitiligo; CRC cis rs7605827 0.930 rs7580672 chr2:15586646 A/G cg19274914 chr2:15703543 NA 0.39 5.9 0.31 8.89e-9 Educational attainment (years of education); CRC cis rs10857712 0.754 rs2297031 chr10:135232654 C/T cg19904058 chr10:135279010 LOC619207 -0.38 -7.25 -0.37 2.94e-12 Systemic lupus erythematosus; CRC cis rs798554 0.757 rs1182185 chr7:2872233 A/G cg13628971 chr7:2884303 GNA12 0.48 6.75 0.35 6.68e-11 Height; CRC cis rs11650494 0.908 rs111834333 chr17:47411814 C/T cg08112188 chr17:47440006 ZNF652 1.17 11.08 0.52 1.78e-24 Prostate cancer; CRC cis rs7107174 0.688 rs11237489 chr11:78130325 G/A cg02023728 chr11:77925099 USP35 0.39 6.05 0.32 3.83e-9 Testicular germ cell tumor; CRC cis rs2617583 0.509 rs2937650 chr5:1458018 C/T cg07148919 chr5:1466943 LPCAT1 0.45 6.02 0.31 4.69e-9 Breast cancer; CRC cis rs4843747 0.671 rs72818540 chr16:88078988 C/T cg03395651 chr16:88107091 BANP 0.53 6.91 0.36 2.53e-11 Menopause (age at onset); CRC cis rs597539 0.615 rs629426 chr11:68671104 A/G cg21963583 chr11:68658836 MRPL21 0.62 11.31 0.53 2.92e-25 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs4920343 0.698 rs578988 chr1:19077291 T/C cg26220594 chr1:19110978 NA 0.36 5.63 0.3 3.85e-8 Knee osteoarthritis; CRC cis rs4363385 0.720 rs1338179 chr1:152981548 T/C cg25856811 chr1:152973957 SPRR3 -0.25 -6.95 -0.36 1.97e-11 Inflammatory skin disease; CRC cis rs7944584 0.588 rs2697923 chr11:47363215 G/T cg20307385 chr11:47447363 PSMC3 -0.68 -9.39 -0.46 1.02e-18 Fasting blood glucose;Fasting blood glucose (BMI interaction); CRC cis rs270601 0.770 rs4361510 chr5:131599647 C/T cg12564285 chr5:131593104 PDLIM4 0.54 10.41 0.5 3.98e-22 Acylcarnitine levels; CRC cis rs6912958 0.559 rs242270 chr6:88062190 C/G cg12350822 chr6:88032061 C6orf162;GJB7 -0.44 -8.98 -0.44 2.14e-17 Monocyte percentage of white cells; CRC cis rs11711311 0.910 rs62265549 chr3:113396234 C/T cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.51 -6.68 -0.35 1.02e-10 IgG glycosylation; CRC cis rs1403694 0.966 rs9869244 chr3:186437554 A/T cg04611788 chr3:186434169 KNG1 -0.45 -6.96 -0.36 1.84e-11 Blood protein levels; CRC cis rs10832963 1.000 rs10128711 chr11:18632984 A/G cg20219074 chr11:18656078 SPTY2D1 0.59 8.45 0.42 9.59e-16 Breast cancer; CRC cis rs6952808 0.608 rs58120505 chr7:2029867 T/C cg21782813 chr7:2030301 MAD1L1 0.52 9.44 0.46 7.03e-19 Bipolar disorder and schizophrenia; CRC cis rs1472147 1.000 rs6970221 chr7:128511024 A/G cg00260937 chr7:128520193 KCP 0.48 7.26 0.37 2.77e-12 Calcium levels; CRC cis rs17767392 0.813 rs61991243 chr14:71847117 A/G cg13720639 chr14:72061746 SIPA1L1 -0.44 -5.71 -0.3 2.53e-8 Mitral valve prolapse; CRC cis rs875971 0.756 rs4718328 chr7:65693337 A/G cg18252515 chr7:66147081 NA 0.39 5.68 0.3 2.99e-8 Aortic root size; CRC cis rs965469 0.901 rs6037563 chr20:3326568 G/A cg25506879 chr20:3388711 C20orf194 -0.37 -5.6 -0.3 4.41e-8 IFN-related cytopenia; CRC cis rs17234274 0.622 rs10767021 chr11:23238782 G/T cg05245346 chr11:23248277 NA 0.34 5.63 0.3 3.79e-8 Cancer; CRC cis rs7072216 0.727 rs10748728 chr10:100171198 C/T cg26618903 chr10:100175079 PYROXD2 -0.55 -8.99 -0.44 2.03e-17 Metabolite levels; CRC cis rs11608355 0.810 rs2217972 chr12:109857612 C/T cg19025524 chr12:109796872 NA -0.46 -6.17 -0.32 2.01e-9 Neuroticism; CRC cis rs1639906 1.000 rs1639906 chr7:2219966 T/C cg19897017 chr7:2163380 MAD1L1 0.43 6.63 0.34 1.4e-10 Colonoscopy-negative controls vs population controls; CRC cis rs13108904 0.557 rs1680033 chr4:1243404 C/T cg16405210 chr4:1374714 KIAA1530 0.74 10.59 0.5 9.5e-23 Obesity-related traits; CRC cis rs2456568 0.900 rs2511399 chr11:93682156 C/T cg26875233 chr11:93583750 C11orf90 0.35 6.9 0.36 2.67e-11 Response to serotonin reuptake inhibitors in major depressive disorder; CRC trans rs7615952 0.733 rs13314847 chr3:125644788 C/T cg16558177 chr4:4109446 NA -0.48 -6.22 -0.32 1.48e-9 Blood pressure (smoking interaction); CRC cis rs9341808 0.652 rs2505940 chr6:80851191 T/C cg08355045 chr6:80787529 NA 0.34 5.82 0.31 1.36e-8 Sitting height ratio; CRC cis rs1552244 1.000 rs17032277 chr3:10077023 T/C cg02579736 chr3:10068473 FANCD2;CIDECP 1.05 14.06 0.61 1.71e-35 Alzheimer's disease; CRC cis rs950776 0.518 rs12906284 chr15:78825105 C/T cg06917634 chr15:78832804 PSMA4 0.66 10.42 0.5 3.55e-22 Sudden cardiac arrest; CRC cis rs9443645 0.901 rs1354831 chr6:79613576 T/C cg11833968 chr6:79620685 NA -0.37 -6.4 -0.33 5.4e-10 Intelligence (multi-trait analysis); CRC cis rs8072100 0.777 rs9914653 chr17:45537395 T/C cg08085267 chr17:45401833 C17orf57 -0.66 -10.87 -0.51 1.03e-23 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs4808199 0.948 rs2023883 chr19:19405480 G/A cg03709012 chr19:19516395 GATAD2A 0.99 11.84 0.55 3.55e-27 Nonalcoholic fatty liver disease; CRC cis rs6504950 0.566 rs7226272 chr17:53046447 G/A cg19360675 chr17:53046073 COX11;STXBP4 0.46 6.87 0.35 3.32e-11 Breast cancer; CRC cis rs1577917 1.000 rs13194429 chr6:86646705 A/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.53 -6.61 -0.34 1.53e-10 Response to antipsychotic treatment; CRC cis rs12144309 0.608 rs1217408 chr1:114396280 T/C cg03325407 chr1:114423726 BCL2L15 0.35 6.54 0.34 2.3e-10 Coronary artery disease; CRC cis rs727563 0.562 rs5758458 chr22:42154132 G/A cg06634786 chr22:41940651 POLR3H 0.66 7.29 0.37 2.28e-12 Crohn's disease;Inflammatory bowel disease; CRC cis rs910316 1.000 rs10143132 chr14:75525850 G/A cg08847533 chr14:75593920 NEK9 0.95 18.13 0.71 2.1e-51 Height; CRC cis rs10256972 0.552 rs2949195 chr7:1202705 G/A cg03923535 chr7:1197113 ZFAND2A 0.74 11.26 0.53 4.14e-25 Longevity;Endometriosis; CRC cis rs4665809 1.000 rs4665816 chr2:26305094 G/C cg04944784 chr2:26401820 FAM59B -0.58 -7.65 -0.39 2.29e-13 Gut microbiome composition (summer); CRC cis rs2839186 0.560 rs9975345 chr21:47843004 T/C cg13012494 chr21:47604986 C21orf56 -0.41 -6.64 -0.34 1.28e-10 Testicular germ cell tumor; CRC cis rs6502050 0.835 rs8078087 chr17:80113322 T/G cg22110888 chr17:80059540 CCDC57 0.4 6.44 0.33 4.17e-10 Life satisfaction; CRC cis rs7107174 0.892 rs2090095 chr11:78034020 G/A cg02023728 chr11:77925099 USP35 0.49 8.81 0.44 7.36e-17 Testicular germ cell tumor; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg23963351 chr1:43834180 ELOVL1 0.45 6.31 0.33 9.11e-10 Response to antipsychotic treatment; CRC cis rs7937682 0.883 rs549143 chr11:111463779 C/T cg09085632 chr11:111637200 PPP2R1B -0.94 -17.74 -0.7 7.01e-50 Primary sclerosing cholangitis; CRC cis rs9902453 0.845 rs7209622 chr17:28256807 C/G cg26525008 chr17:28256777 EFCAB5;SSH2 0.75 12.7 0.57 2.34e-30 Coffee consumption (cups per day); CRC cis rs4713118 0.621 rs10484403 chr6:28033523 A/G cg23161317 chr6:28129485 ZNF389 0.52 6.57 0.34 1.92e-10 Parkinson's disease; CRC cis rs629535 0.767 rs72654070 chr8:70079369 G/A cg26132723 chr8:70041827 NA -0.35 -5.63 -0.3 3.87e-8 Dupuytren's disease; CRC cis rs28386778 0.863 rs2584637 chr17:61942952 T/C cg06873352 chr17:61820015 STRADA 0.76 14.26 0.62 2.86e-36 Prudent dietary pattern; CRC cis rs12762955 0.561 rs10752022 chr10:1043798 C/T cg19847866 chr10:1019161 NA 0.4 5.82 0.31 1.43e-8 Response to angiotensin II receptor blocker therapy; CRC cis rs3931020 0.548 rs17618340 chr1:75247617 G/A cg00121533 chr1:75199117 CRYZ;TYW3 0.48 6.43 0.33 4.56e-10 Resistin levels; CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg05886006 chr1:161359784 NA -0.49 -5.96 -0.31 6.47e-9 Diisocyanate-induced asthma; CRC cis rs6831352 0.918 rs13110764 chr4:100062466 C/T cg12011299 chr4:100065546 ADH4 -0.5 -9.63 -0.47 1.7e-19 Alcohol dependence; CRC trans rs9388451 0.839 rs4897157 chr6:126102981 A/T cg05039488 chr6:79577232 IRAK1BP1 -0.55 -8.28 -0.42 3.05e-15 Brugada syndrome; CRC cis rs2404602 0.716 rs56216512 chr15:76686936 T/C cg23625390 chr15:77176239 SCAPER 0.51 7.43 0.38 9.65e-13 Blood metabolite levels; CRC cis rs2243480 1.000 rs1796228 chr7:66033084 G/A cg18252515 chr7:66147081 NA -1.28 -15.37 -0.65 1.5e-40 Diabetic kidney disease; CRC cis rs9611519 0.929 rs2064560 chr22:41530040 A/G cg06634786 chr22:41940651 POLR3H -0.46 -5.88 -0.31 1.02e-8 Neuroticism; CRC cis rs10504229 0.679 rs17800895 chr8:58050085 A/G cg02290350 chr8:58132656 NA -0.54 -6.4 -0.33 5.38e-10 Developmental language disorder (linguistic errors); CRC cis rs8177253 0.665 rs9831392 chr3:133451473 A/T cg17775713 chr3:133465469 TF 0.33 5.85 0.31 1.19e-8 Iron status biomarkers; CRC cis rs7772486 0.790 rs2247666 chr6:146220409 C/A cg13319975 chr6:146136371 FBXO30 -0.43 -6.53 -0.34 2.56e-10 Lobe attachment (rater-scored or self-reported); CRC cis rs10504229 0.683 rs66730544 chr8:58127280 A/T cg22535103 chr8:58192502 C8orf71 -0.7 -9.34 -0.46 1.47e-18 Developmental language disorder (linguistic errors); CRC cis rs9611565 0.649 rs79009 chr22:41860864 C/A cg17554472 chr22:41940697 POLR3H 0.52 5.62 0.3 4.16e-8 Vitiligo; CRC cis rs7760949 0.889 rs9382688 chr6:13926746 A/T cg27413430 chr6:13925136 RNF182 0.34 5.88 0.31 1.01e-8 Mean corpuscular hemoglobin concentration; CRC cis rs881375 0.669 rs73541868 chr9:123639264 G/A cg09419670 chr9:123605666 PSMD5;LOC253039 0.46 7.13 0.37 6.46e-12 Rheumatoid arthritis; CRC cis rs11792861 0.926 rs17729523 chr9:111773317 T/C cg05043794 chr9:111880884 C9orf5 -0.34 -6.03 -0.32 4.31e-9 Menarche (age at onset); CRC cis rs216303 0.570 rs216339 chr12:6149284 T/C cg19878637 chr12:6148451 VWF -0.6 -5.94 -0.31 7.1e-9 Low vWF levels; CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg08077726 chr17:74734280 SFRS2;MFSD11 -0.52 -6.09 -0.32 3.07e-9 Diisocyanate-induced asthma; CRC cis rs2077654 0.908 rs7926934 chr11:17433088 A/C cg25308976 chr11:17434268 ABCC8 0.8 8.33 0.42 2.26e-15 Gout; CRC trans rs11148252 0.846 rs7333451 chr13:53047709 G/A cg18335740 chr13:41363409 SLC25A15 0.54 8.42 0.42 1.14e-15 Lewy body disease; CRC cis rs6502050 0.835 rs7502548 chr17:80087569 T/C cg19223190 chr17:80058835 NA -0.39 -6.09 -0.32 3.08e-9 Life satisfaction; CRC cis rs2249694 0.803 rs3020501 chr10:135381592 C/G cg20169779 chr10:135381914 SYCE1 0.63 10.42 0.5 3.72e-22 Obesity-related traits; CRC cis rs3018066 0.836 rs13114479 chr4:107172679 C/T cg01869342 chr4:106983673 TBCK -0.36 -5.63 -0.3 3.82e-8 Cancer; CRC cis rs4665809 0.531 rs3892649 chr2:26457267 T/G cg25036284 chr2:26402008 FAM59B 0.62 7.86 0.4 5.64e-14 Gut microbiome composition (summer); CRC cis rs2840044 1.000 rs10068 chr17:33901965 C/G cg05299278 chr17:33885742 SLFN14 -0.41 -6.26 -0.33 1.22e-9 Response to radiotherapy in cancer (late toxicity); CRC cis rs59918340 0.728 rs6987335 chr8:142235358 T/G cg17298326 chr8:142245477 NA 0.42 6.28 0.33 1.04e-9 Immature fraction of reticulocytes; CRC cis rs1153858 1.000 rs7402650 chr15:45701895 C/T cg10760299 chr15:45669010 GATM 0.52 7.85 0.4 6.09e-14 Homoarginine levels; CRC cis rs2179367 0.959 rs628488 chr6:149719400 G/A cg11245181 chr6:149772854 ZC3H12D -0.41 -6.18 -0.32 1.93e-9 Dupuytren's disease; CRC cis rs344364 0.511 rs337284 chr16:1954799 A/C cg09830162 chr16:1889614 FAHD1;C16orf73 -0.74 -9.25 -0.45 2.97e-18 Glomerular filtration rate in chronic kidney disease; CRC cis rs7772486 0.713 rs79248977 chr6:146319388 C/A cg23711669 chr6:146136114 FBXO30 0.68 11.27 0.53 4.04e-25 Lobe attachment (rater-scored or self-reported); CRC cis rs1401999 1.000 rs4148571 chr3:183720576 A/C cg01324343 chr3:183735012 ABCC5 0.8 14.58 0.63 1.67e-37 Anterior chamber depth; CRC cis rs597539 0.652 rs602805 chr11:68662076 A/T cg06028808 chr11:68637592 NA 0.42 6.66 0.34 1.12e-10 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs12155623 1.000 rs12155623 chr8:49812201 A/T cg00325661 chr8:49890786 NA -0.35 -6.0 -0.31 5.25e-9 Sudden cardiac arrest; CRC cis rs4889911 0.544 rs1285273 chr17:77830885 A/G cg00646381 chr17:77835854 NA 0.42 6.63 0.34 1.39e-10 Electroencephalogram traits; CRC cis rs929354 0.709 rs1182363 chr7:157019151 A/G cg17757837 chr7:157058334 UBE3C -0.76 -12.9 -0.58 4.36e-31 Body mass index; CRC cis rs7224685 0.501 rs1377806 chr17:4019966 A/G cg10724054 chr17:3904396 NA -0.45 -7.54 -0.38 4.61e-13 Type 2 diabetes; CRC cis rs7493 0.950 rs12704794 chr7:95036133 A/T cg07404485 chr7:94953653 PON1 -0.45 -6.04 -0.32 4.26e-9 Yu-Zhi constitution type in type 2 diabetes; CRC trans rs11098499 0.954 rs12507964 chr4:120413061 T/A cg25214090 chr10:38739885 LOC399744 0.66 10.54 0.5 1.46e-22 Corneal astigmatism; CRC trans rs1161463 0.789 rs1027416 chr13:29429051 T/G cg16311697 chr3:124249497 KALRN -0.45 -6.12 -0.32 2.6e-9 Attention deficit hyperactivity disorder symptoms (maternal expressed emotions interaction); CRC cis rs597539 0.652 rs546382 chr11:68704264 C/T cg21963583 chr11:68658836 MRPL21 0.58 10.42 0.5 3.71e-22 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs7618915 0.501 rs3733039 chr3:52719088 C/T cg18404041 chr3:52824283 ITIH1 -0.4 -8.46 -0.42 8.81e-16 Bipolar disorder; CRC cis rs1215050 0.791 rs503863 chr4:98707663 T/C cg05340658 chr4:99064831 C4orf37 0.48 7.09 0.36 8.48e-12 Waist-to-hip ratio adjusted for body mass index; CRC cis rs4481887 0.636 rs10788761 chr1:248410663 C/T cg00666640 chr1:248458726 OR2T12 0.48 7.78 0.39 9.44e-14 Common traits (Other); CRC cis rs2115536 0.967 rs3826008 chr15:80189805 G/T cg00225070 chr15:80189496 MTHFS 0.51 8.11 0.41 9.81e-15 Eosinophil counts;Eosinophil percentage of white cells;Sum eosinophil basophil counts;Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; CRC cis rs1862618 0.802 rs986049 chr5:56110233 G/A cg22800045 chr5:56110881 MAP3K1 0.54 5.89 0.31 9.47e-9 Initial pursuit acceleration; CRC cis rs1448094 0.511 rs59668915 chr12:86197170 C/T cg19622623 chr12:86230825 RASSF9 -0.37 -5.93 -0.31 7.48e-9 Major depressive disorder; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg26182254 chr15:57210406 LOC145783;TCF12 0.38 6.2 0.32 1.72e-9 Intelligence (multi-trait analysis); CRC cis rs1983891 1.000 rs1983891 chr6:41536427 A/G cg20194872 chr6:41519635 FOXP4 -0.39 -5.68 -0.3 3.01e-8 Prostate cancer; CRC cis rs951366 0.617 rs823074 chr1:205774839 T/C cg11965913 chr1:205819406 PM20D1 1.03 19.83 0.74 3.98e-58 Menarche (age at onset); CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg12393716 chr11:62495049 TTC9C;HNRNPUL2 -0.52 -6.3 -0.33 9.41e-10 Diisocyanate-induced asthma; CRC cis rs6964587 0.967 rs17164315 chr7:91659150 C/G cg17063962 chr7:91808500 NA 0.8 14.35 0.62 1.28e-36 Breast cancer; CRC cis rs992157 0.835 rs10932768 chr2:219146199 T/A cg13835894 chr2:219148914 PNKD;TMBIM1 -0.36 -6.82 -0.35 4.44e-11 Colorectal cancer; CRC cis rs9807841 0.592 rs3810155 chr19:10764867 C/G cg17710535 chr19:10819994 QTRT1 0.44 6.54 0.34 2.3e-10 Inflammatory skin disease; CRC cis rs995000 0.931 rs634341 chr1:62921422 T/C cg19896129 chr1:63156450 NA 0.44 6.78 0.35 5.59e-11 Triglyceride levels; CRC cis rs6540559 0.673 rs58637469 chr1:209971480 T/A cg22029157 chr1:209979665 IRF6 0.73 9.57 0.47 2.65e-19 Cleft lip with or without cleft palate; CRC cis rs1552244 0.938 rs56274701 chr3:10167790 G/A cg00166722 chr3:10149974 C3orf24 0.67 8.87 0.44 4.81e-17 Alzheimer's disease; CRC cis rs7772486 0.603 rs2223411 chr6:146028767 T/C cg23711669 chr6:146136114 FBXO30 -0.62 -9.16 -0.45 5.63e-18 Lobe attachment (rater-scored or self-reported); CRC trans rs877282 0.682 rs2265092 chr10:780293 C/T cg22713356 chr15:30763199 NA -0.8 -11.2 -0.53 6.83e-25 Uric acid levels; CRC cis rs4803468 1.000 rs11670668 chr19:41920454 G/C cg09537434 chr19:41945824 ATP5SL -0.97 -18.81 -0.72 4.3e-54 Height; CRC cis rs4901869 0.966 rs12878614 chr14:59339477 A/C cg02291164 chr14:59296302 NA 0.35 6.53 0.34 2.49e-10 Panic disorder; CRC cis rs3026101 0.624 rs60116755 chr17:5303215 G/A cg25236894 chr17:5323110 RPAIN;NUP88 0.43 6.93 0.36 2.22e-11 Body mass index; CRC trans rs2243480 0.901 rs35256305 chr7:65306405 T/C cg10756647 chr7:56101905 PSPH 0.73 7.72 0.39 1.46e-13 Diabetic kidney disease; CRC cis rs9486715 0.838 rs9486275 chr6:96901187 C/T cg06623918 chr6:96969491 KIAA0776 1.01 20.28 0.75 6.6e-60 Headache; CRC cis rs1008375 0.966 rs4698642 chr4:17679174 A/T cg16339924 chr4:17578868 LAP3 0.51 6.67 0.35 1.09e-10 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs2075371 1.000 rs1421484 chr7:133979795 T/C cg02659138 chr7:134003124 SLC35B4 0.37 6.38 0.33 6e-10 Mean platelet volume; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg10030417 chr3:11102607 NA 0.45 6.05 0.32 3.88e-9 Anxiety disorder; CRC cis rs9443645 0.901 rs9361480 chr6:79724429 C/T cg09184832 chr6:79620586 NA -0.47 -8.48 -0.42 7.49e-16 Intelligence (multi-trait analysis); CRC cis rs394563 0.591 rs6570964 chr6:149691859 G/A cg11245181 chr6:149772854 ZC3H12D 0.52 9.12 0.45 7.83e-18 Dupuytren's disease; CRC cis rs10504229 0.953 rs59265461 chr8:58189701 A/T cg02290350 chr8:58132656 NA -0.42 -5.96 -0.31 6.62e-9 Developmental language disorder (linguistic errors); CRC cis rs9463078 0.753 rs3778507 chr6:44896803 G/A cg25276700 chr6:44698697 NA -0.28 -6.73 -0.35 7.44e-11 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; CRC cis rs995000 0.931 rs116405518 chr1:63036807 G/A cg19896129 chr1:63156450 NA -0.44 -6.85 -0.35 3.55e-11 Triglyceride levels; CRC cis rs10924970 0.874 rs6681842 chr1:235332555 G/T cg26050004 chr1:235667680 B3GALNT2 0.4 5.8 0.3 1.58e-8 Asthma; CRC cis rs2124969 0.548 rs62175384 chr2:161011128 C/T cg03641300 chr2:160917029 PLA2R1 -0.66 -8.36 -0.42 1.81e-15 Waist circumference adjusted for body mass index; CRC cis rs2380220 0.606 rs4559095 chr6:95994154 A/C cg15832292 chr6:96025679 MANEA 0.57 6.39 0.33 5.75e-10 Behavioural disinhibition (generation interaction); CRC cis rs7904368 0.754 rs11254231 chr10:16870246 A/G cg14835575 chr10:16859367 RSU1 0.44 6.13 0.32 2.53e-9 Ratio of the peak velocity of the mitral E-Wave divided by the peak velocity of the mitral A-wave.; CRC cis rs59918340 0.728 rs2304279 chr8:142229891 A/G cg17298326 chr8:142245477 NA -0.37 -5.63 -0.3 3.96e-8 Immature fraction of reticulocytes; CRC cis rs11958404 0.860 rs11135023 chr5:157420082 G/T cg05962755 chr5:157440814 NA 0.77 11.37 0.53 1.74e-25 IgG glycosylation; CRC cis rs2425143 0.822 rs6060677 chr20:34499368 A/G cg04508476 chr20:34239394 CPNE1;RBM12 0.53 6.15 0.32 2.21e-9 Blood protein levels; CRC cis rs11098499 0.954 rs12510138 chr4:120423935 C/G cg09307838 chr4:120376055 NA 0.71 10.9 0.51 8.17e-24 Corneal astigmatism; CRC cis rs7289126 0.966 rs4820329 chr22:38646063 G/A cg25457927 chr22:38595422 NA -0.32 -6.25 -0.33 1.28e-9 Mammographic density (dense area);Percent mammographic density; CRC cis rs9916302 0.706 rs3744349 chr17:37414842 C/T cg15445000 chr17:37608096 MED1 0.32 5.67 0.3 3.06e-8 Glomerular filtration rate (creatinine); CRC cis rs4664293 0.867 rs34795915 chr2:160588931 A/T cg08347373 chr2:160653686 CD302 -0.47 -7.43 -0.38 9.32e-13 Monocyte percentage of white cells; CRC cis rs10771431 0.597 rs10843142 chr12:9357502 A/G cg22349387 chr12:9600060 DDX12 -0.36 -5.66 -0.3 3.26e-8 Breast size; CRC cis rs9308731 0.644 rs56952027 chr2:111877104 C/T cg18646521 chr2:111875858 NA 0.37 5.85 0.31 1.19e-8 Chronic lymphocytic leukemia; CRC cis rs72717009 0.825 rs11810143 chr1:161480649 A/G cg10431340 chr1:161279108 MPZ -0.52 -6.78 -0.35 5.55e-11 Rheumatoid arthritis; CRC cis rs10504229 1.000 rs17805332 chr8:58169798 A/G cg22535103 chr8:58192502 C8orf71 -0.8 -12.24 -0.56 1.17e-28 Developmental language disorder (linguistic errors); CRC trans rs7615952 0.546 rs2922171 chr3:125343193 C/T cg21747405 chr11:67723411 NA -0.49 -6.32 -0.33 8.59e-10 Blood pressure (smoking interaction); CRC cis rs13064411 0.542 rs7631335 chr3:113209166 C/T cg18753928 chr3:113234510 CCDC52 -0.53 -8.2 -0.41 5.32e-15 Response to simvastatin treatment (PCSK9 protein level change); CRC trans rs10506458 0.915 rs60094497 chr12:63394838 T/G cg22491629 chr6:157744540 C6orf35 -0.77 -9.05 -0.45 1.31e-17 Hemostatic factors and hematological phenotypes; CRC cis rs2762353 0.595 rs13194155 chr6:25755508 C/T cg12310025 chr6:25882481 NA 0.74 10.47 0.5 2.54e-22 Blood metabolite levels; CRC cis rs8078723 1.000 rs3213762 chr17:38178627 A/G cg17467752 chr17:38218738 THRA 0.76 12.12 0.56 3.36e-28 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); CRC cis rs9435341 0.965 rs6669831 chr1:107608607 G/A cg15468180 chr1:107600409 PRMT6 -0.38 -5.99 -0.31 5.44e-9 Facial morphology (factor 21, depth of nasal alae); CRC trans rs1005277 0.579 rs2504140 chr10:38387579 T/G cg27523141 chr10:43048294 ZNF37B 0.49 7.21 0.37 3.88e-12 Extrinsic epigenetic age acceleration; CRC cis rs2153535 0.563 rs6942177 chr6:8534460 A/G cg07606381 chr6:8435919 SLC35B3 -0.67 -10.9 -0.51 8.16e-24 Motion sickness; CRC cis rs6921919 0.583 rs6899389 chr6:28381140 C/A cg21251018 chr6:28226885 NKAPL 0.39 5.93 0.31 7.61e-9 Autism spectrum disorder or schizophrenia; CRC cis rs1572438 0.811 rs6916756 chr6:880467 G/A cg21062780 chr6:887772 NA 0.41 6.67 0.35 1.09e-10 Aging; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg21126573 chr17:7755257 KDM6B 0.44 6.15 0.32 2.25e-9 Response to antipsychotic treatment; CRC cis rs68170813 0.559 rs12540475 chr7:106886295 C/T cg02696742 chr7:106810147 HBP1 -0.6 -6.5 -0.34 3.05e-10 Coronary artery disease; CRC cis rs172166 0.516 rs2622322 chr6:28117443 C/G cg12172441 chr6:28176163 NA 0.45 6.55 0.34 2.16e-10 Cardiac Troponin-T levels; CRC cis rs10503871 0.967 rs2294085 chr8:30436779 C/T cg26383811 chr8:30366931 RBPMS 0.45 7.39 0.38 1.24e-12 Metabolite levels (X-11787); CRC trans rs2303319 0.504 rs16846047 chr2:162561946 T/C cg18122310 chr12:50236657 BCDIN3D -0.74 -6.19 -0.32 1.81e-9 Cognitive function; CRC cis rs877282 0.838 rs11253374 chr10:774961 C/T cg17470449 chr10:769945 NA 0.64 8.83 0.44 6.42e-17 Uric acid levels; CRC cis rs4713118 0.527 rs36042294 chr6:27720712 C/G cg15786705 chr6:28176104 NA 0.49 7.03 0.36 1.18e-11 Parkinson's disease; CRC cis rs2179367 0.959 rs237034 chr6:149711862 A/C cg07828024 chr6:149772892 ZC3H12D -0.38 -6.0 -0.31 5.23e-9 Dupuytren's disease; CRC cis rs41271951 0.512 rs12058128 chr1:151106113 C/T cg11822372 chr1:151115635 SEMA6C -0.72 -5.81 -0.31 1.46e-8 Blood protein levels; CRC cis rs796364 0.806 rs11679658 chr2:200923081 A/G cg25936922 chr2:200820526 C2orf60;C2orf47 -0.7 -6.62 -0.34 1.47e-10 Schizophrenia; CRC cis rs3008870 0.727 rs2862729 chr1:67500828 T/C cg08660285 chr1:67390436 MIER1;WDR78 0.54 7.31 0.37 2.07e-12 Lymphocyte percentage of white cells; CRC cis rs1448094 0.512 rs7299285 chr12:86244959 A/T cg25456477 chr12:86230367 RASSF9 0.32 5.63 0.3 3.86e-8 Major depressive disorder; CRC cis rs10504229 0.679 rs72649115 chr8:58037631 T/G cg08219700 chr8:58056026 NA 0.53 6.09 0.32 3.21e-9 Developmental language disorder (linguistic errors); CRC cis rs7243821 0.847 rs2187412 chr18:52704561 C/T cg16669619 chr18:52630472 NA -0.43 -6.4 -0.33 5.2e-10 Chin dimples; CRC cis rs116095464 0.558 rs6874745 chr5:264527 A/G cg22496380 chr5:211416 CCDC127 -0.91 -10.46 -0.5 2.65e-22 Breast cancer; CRC trans rs4276421 0.806 rs6414906 chr5:45406321 T/C cg04793272 chr11:119020941 ABCG4 -0.37 -6.03 -0.32 4.31e-9 P wave duration; CRC cis rs13191362 0.935 rs67337490 chr6:162953961 G/A cg21926612 chr6:163149169 PACRG;PARK2 0.82 10.27 0.49 1.24e-21 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs1865760 0.865 rs1115920 chr6:25954027 A/G cg16482183 chr6:26056742 HIST1H1C 0.54 7.94 0.4 3.26e-14 Height; CRC cis rs1355223 0.507 rs11032903 chr11:34876176 C/T cg11058730 chr11:34937778 PDHX;APIP -0.43 -6.07 -0.32 3.51e-9 Systemic lupus erythematosus and Systemic sclerosis; CRC cis rs7914558 0.966 rs4917997 chr10:104945213 A/G cg15744005 chr10:104629667 AS3MT -0.34 -7.2 -0.37 4.18e-12 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs534126 0.813 rs526867 chr7:142904427 G/A cg04039957 chr7:143013207 CLCN1 0.35 6.07 0.32 3.58e-9 Cancer; CRC cis rs9308731 0.644 rs3789064 chr2:111915322 T/C cg18646521 chr2:111875858 NA 0.38 5.99 0.31 5.36e-9 Chronic lymphocytic leukemia; CRC cis rs9399135 0.967 rs1014020 chr6:135334426 C/A cg24558204 chr6:135376177 HBS1L 0.51 8.11 0.41 1.01e-14 Red blood cell count; CRC cis rs60843830 1.000 rs3791224 chr2:221981 C/T cg25945732 chr2:264204 ACP1;SH3YL1 0.72 11.7 0.54 1.16e-26 Spherical equivalent (joint analysis main effects and education interaction); CRC cis rs172166 0.561 rs149974 chr6:27985096 T/C cg15786705 chr6:28176104 NA 0.47 6.9 0.36 2.66e-11 Cardiac Troponin-T levels; CRC cis rs9611565 0.659 rs1569516 chr22:41910244 C/T cg06481639 chr22:41940642 POLR3H -0.57 -6.62 -0.34 1.5e-10 Vitiligo; CRC cis rs826838 0.559 rs1843891 chr12:38617018 T/C cg26384229 chr12:38710491 ALG10B 0.43 6.25 0.33 1.26e-9 Heart rate; CRC cis rs8067545 0.750 rs11869616 chr17:19992713 G/A cg13482628 chr17:19912719 NA 0.46 7.55 0.38 4.46e-13 Schizophrenia; CRC cis rs7618915 0.571 rs12487445 chr3:52618319 A/C cg08222913 chr3:52553049 STAB1 -0.34 -6.12 -0.32 2.59e-9 Bipolar disorder; CRC cis rs853679 0.550 rs1225598 chr6:28160799 T/G cg25164649 chr6:28176230 NA 0.79 11.08 0.52 1.9e-24 Depression; CRC cis rs2013441 0.866 rs12947950 chr17:20045176 C/T cg13482628 chr17:19912719 NA 0.4 5.76 0.3 1.92e-8 Obesity-related traits; CRC cis rs6732160 0.588 rs1430344 chr2:73373344 G/A cg01422370 chr2:73384389 NA 0.37 5.8 0.3 1.57e-8 Intelligence (multi-trait analysis); CRC cis rs9467711 0.606 rs2076030 chr6:26426856 G/A cg08501292 chr6:25962987 TRIM38 0.79 6.17 0.32 2e-9 Autism spectrum disorder or schizophrenia; CRC cis rs6761276 0.649 rs10181720 chr2:113838608 A/G cg09040174 chr2:113837401 NA 0.6 9.43 0.46 7.69e-19 Protein quantitative trait loci; CRC cis rs7932354 0.537 rs3816614 chr11:46890165 C/T cg19486271 chr11:47235900 DDB2 -0.42 -6.34 -0.33 7.49e-10 Bone mineral density (hip);Bone mineral density; CRC cis rs9891119 0.602 rs1905340 chr17:40520390 C/A cg06270615 chr17:40516068 STAT3 -0.34 -7.18 -0.37 4.65e-12 Multiple sclerosis;Crohn's disease; CRC cis rs597539 0.616 rs72945243 chr11:68633358 T/C cg06028808 chr11:68637592 NA 0.41 6.75 0.35 6.67e-11 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs55871839 0.708 rs4738731 chr8:59809840 C/G cg07426533 chr8:59803705 TOX -0.32 -5.62 -0.3 4.17e-8 Pneumonia; CRC trans rs1814175 0.935 rs11040462 chr11:49683158 G/A cg15704280 chr7:45808275 SEPT13 -0.97 -18.13 -0.71 2e-51 Height; CRC cis rs798554 1.000 rs798544 chr7:2763102 A/G cg13628971 chr7:2884303 GNA12 -0.47 -6.59 -0.34 1.73e-10 Height; CRC cis rs853679 0.517 rs9380049 chr6:28048535 A/G cg15845792 chr6:28175446 NA 0.97 13.03 0.58 1.43e-31 Depression; CRC cis rs9787249 0.957 rs56064244 chr1:40213890 C/T cg01941586 chr1:40203715 PPIE -0.45 -6.21 -0.32 1.59e-9 Blood protein levels; CRC cis rs875971 0.893 rs62465470 chr7:65601218 T/C cg11764359 chr7:65958608 NA -0.59 -8.97 -0.44 2.35e-17 Aortic root size; CRC cis rs62432291 0.614 rs452112 chr6:159658028 A/G cg14500486 chr6:159655392 FNDC1 -0.75 -10.12 -0.49 3.83e-21 Joint mobility (Beighton score); CRC cis rs3087591 0.708 rs2525569 chr17:29675971 T/A cg24425628 chr17:29625626 OMG;NF1 0.71 13.19 0.59 3.46e-32 Hip circumference; CRC cis rs9611565 0.569 rs188057 chr22:41822305 T/G cg06481639 chr22:41940642 POLR3H 0.51 5.63 0.3 3.96e-8 Vitiligo; CRC trans rs12599106 0.792 rs12597352 chr16:34638507 A/T cg15383120 chr6:291909 DUSP22 -0.5 -7.04 -0.36 1.15e-11 Menopause (age at onset); CRC cis rs720844 0.748 rs6746352 chr2:149352353 A/G cg09247360 chr2:149335327 NA 0.57 6.42 0.33 4.65e-10 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs7927771 0.864 rs2868459 chr11:47454972 C/G cg05585544 chr11:47624801 NA -0.53 -9.45 -0.46 6.77e-19 Subjective well-being; CRC cis rs7246865 0.954 rs10427132 chr19:17207156 T/G cg19418318 chr19:17219073 MYO9B 0.51 8.79 0.44 8.54e-17 Reticulocyte fraction of red cells; CRC cis rs4434138 0.594 rs7653028 chr3:52763000 A/T cg15147215 chr3:52552868 STAB1 -0.62 -10.72 -0.51 3.45e-23 Intelligence (multi-trait analysis); CRC cis rs926938 0.557 rs6667218 chr1:115238982 G/A cg12756093 chr1:115239321 AMPD1 -0.67 -9.77 -0.47 5.62e-20 Autism; CRC cis rs9611519 1.000 rs9611520 chr22:41613303 C/T cg03806693 chr22:41940476 POLR3H -0.59 -7.62 -0.39 2.82e-13 Neuroticism; CRC cis rs3824347 0.839 rs7857510 chr9:77625711 A/G cg01251476 chr9:77566080 C9orf40 0.36 5.61 0.3 4.25e-8 Urinary magnesium-to-creatinine ratio; CRC cis rs7707921 0.881 rs2407153 chr5:81555328 T/G cg17942617 chr5:81327376 ATG10 -0.38 -5.71 -0.3 2.55e-8 Breast cancer; CRC cis rs514406 0.825 rs6695819 chr1:53223366 T/C cg27535305 chr1:53392650 SCP2 0.38 6.97 0.36 1.77e-11 Monocyte count; CRC cis rs1003719 0.680 rs7275984 chr21:38505696 C/A cg10648535 chr21:38446584 PIGP;TTC3 -0.48 -6.7 -0.35 8.99e-11 Eye color traits; CRC trans rs7937682 1.000 rs2186839 chr11:111534442 T/G cg18187862 chr3:45730750 SACM1L 0.51 7.38 0.38 1.32e-12 Primary sclerosing cholangitis; CRC trans rs801193 0.761 rs2659888 chr7:66230171 T/G cg05627663 chr7:65219948 SNORA22;CCT6P1 0.41 5.98 0.31 5.94e-9 Aortic root size; CRC cis rs1670533 1.000 rs13135215 chr4:1054364 A/G cg27284194 chr4:1044797 NA 0.5 6.2 0.32 1.66e-9 Recombination rate (females); CRC cis rs4975709 0.589 rs1684967 chr5:1863055 G/C cg20790798 chr5:1857306 NA -0.38 -5.84 -0.31 1.27e-8 Cardiovascular disease risk factors; CRC cis rs896854 0.902 rs896852 chr8:95960886 G/T cg09323728 chr8:95962352 TP53INP1 -0.42 -6.79 -0.35 5.16e-11 Type 2 diabetes; CRC trans rs11039798 0.588 rs589834 chr11:48419382 C/G cg15704280 chr7:45808275 SEPT13 -0.68 -7.45 -0.38 8.34e-13 Axial length; CRC trans rs10983614 1.000 rs7867776 chr9:120072627 A/G cg19483816 chr5:180670343 GNB2L1;SNORD95;SNORD96A 0.43 5.97 0.31 6.23e-9 Survival in pancreatic cancer; CRC cis rs1005277 0.602 rs1740743 chr10:38519222 C/T cg03665457 chr10:38645376 HSD17B7P2 -0.42 -5.96 -0.31 6.58e-9 Extrinsic epigenetic age acceleration; CRC cis rs908922 0.676 rs945788 chr1:152512762 A/G cg09873164 chr1:152488093 CRCT1 0.37 6.15 0.32 2.19e-9 Hair morphology; CRC cis rs780096 0.506 rs1728922 chr2:27644464 A/C cg24768116 chr2:27665128 KRTCAP3 -0.35 -7.99 -0.4 2.25e-14 Total body bone mineral density; CRC cis rs853679 0.550 rs1225598 chr6:28160799 T/G cg02683197 chr6:28174875 NA 0.88 12.35 0.56 4.59e-29 Depression; CRC cis rs6502050 0.835 rs3924781 chr17:80113130 T/C cg02741985 chr17:80059408 CCDC57 0.44 7.17 0.37 5.01e-12 Life satisfaction; CRC cis rs1577917 0.739 rs9450318 chr6:86427177 G/A cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A 0.58 8.25 0.41 3.96e-15 Response to antipsychotic treatment; CRC cis rs4665809 1.000 rs2053367 chr2:26293413 T/C cg26119090 chr2:26468346 HADHA;HADHB -0.61 -7.82 -0.4 7.04e-14 Gut microbiome composition (summer); CRC cis rs7811142 0.943 rs67196635 chr7:100025564 T/C cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.91 12.61 0.57 5.01e-30 Platelet count; CRC cis rs2976388 0.609 rs2585149 chr8:143793320 T/C cg22687807 chr8:143858763 LYNX1 0.51 9.17 0.45 5.35e-18 Urinary tract infection frequency; CRC cis rs12701220 0.604 rs12702122 chr7:1149494 C/G cg26769984 chr7:1090371 C7orf50 0.55 7.6 0.39 3.08e-13 Bronchopulmonary dysplasia; CRC trans rs1005277 0.557 rs176887 chr10:38406094 T/C cg23533926 chr12:111358616 MYL2 -0.52 -7.83 -0.4 6.66e-14 Extrinsic epigenetic age acceleration; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg14287603 chr2:120771169 EPB41L5 0.44 6.58 0.34 1.83e-10 Response to antipsychotic treatment; CRC cis rs2303759 0.666 rs66967196 chr19:49808894 G/A cg22590775 chr19:49891494 CCDC155 0.58 7.57 0.39 3.82e-13 Multiple sclerosis; CRC trans rs1005277 0.528 rs2057228 chr10:38515766 T/C cg11292332 chr7:45801988 SEPT13 -0.39 -7.05 -0.36 1.05e-11 Extrinsic epigenetic age acceleration; CRC cis rs7584330 0.554 rs3751111 chr2:238426953 G/T cg14458575 chr2:238380390 NA 0.46 6.53 0.34 2.47e-10 Prostate cancer; CRC cis rs2857891 0.909 rs56261447 chr11:6939382 A/C cg06872519 chr11:6947619 ZNF215 0.58 5.79 0.3 1.68e-8 Response to cytadine analogues (cytosine arabinoside); CRC cis rs734999 0.588 rs2843404 chr1:2530558 T/C cg18854424 chr1:2615690 NA -0.42 -8.07 -0.41 1.3e-14 Ulcerative colitis; CRC cis rs9787249 0.957 rs7548120 chr1:40204424 A/T cg19912559 chr1:40204330 PPIE 0.51 7.43 0.38 9.67e-13 Blood protein levels; CRC cis rs432925 0.600 rs214249 chr16:348687 T/G cg08823186 chr16:347294 AXIN1 0.49 7.57 0.39 3.72e-13 Morning vs. evening chronotype; CRC cis rs1065852 0.526 rs1062753 chr22:42392811 G/A cg00645731 chr22:42541494 CYP2D7P1 0.4 6.85 0.35 3.61e-11 Response to serotonin reuptake inhibitors in major depressive disorder (plasma drug and metabolite levels); CRC cis rs6696846 0.765 rs2836 chr1:205111761 G/T cg00857998 chr1:205179979 DSTYK -0.46 -6.34 -0.33 7.78e-10 Red blood cell count; CRC cis rs2197308 0.765 rs12230545 chr12:37927114 C/T cg13010199 chr12:38710504 ALG10B -0.47 -6.9 -0.36 2.69e-11 Morning vs. evening chronotype; CRC cis rs2153535 0.580 rs9378556 chr6:8514695 A/G cg07606381 chr6:8435919 SLC35B3 0.66 10.72 0.51 3.48e-23 Motion sickness; CRC cis rs7127900 0.583 rs11043147 chr11:2234169 C/G cg25635251 chr11:2234043 NA 0.33 6.64 0.34 1.29e-10 Prostate cancer;Prostate cancer (SNP x SNP interaction);Prostate cancer (early onset); CRC trans rs17270561 0.609 rs1165156 chr6:25792978 T/C cg02936872 chr9:99801550 CTSL2 0.48 6.18 0.32 1.85e-9 Iron status biomarkers; CRC cis rs6502050 0.712 rs8077079 chr17:80059011 C/T cg02741985 chr17:80059408 CCDC57 -0.44 -7.09 -0.36 8.06e-12 Life satisfaction; CRC cis rs1124376 1.000 rs9828701 chr3:20149203 A/G cg05072819 chr3:20081367 KAT2B 0.48 5.8 0.3 1.57e-8 Bipolar disorder and schizophrenia; CRC cis rs12477438 0.798 rs7606635 chr2:99644782 G/A cg26064155 chr2:99771622 LIPT1;TSGA10 -0.63 -8.55 -0.43 4.57e-16 Chronic sinus infection; CRC trans rs61931739 0.500 rs11053199 chr12:34450534 C/T cg13010199 chr12:38710504 ALG10B -0.45 -6.45 -0.34 3.88e-10 Morning vs. evening chronotype; CRC cis rs908922 0.676 rs498184 chr1:152501423 G/C cg09873164 chr1:152488093 CRCT1 0.37 6.04 0.32 4.17e-9 Hair morphology; CRC cis rs9549367 0.789 rs34568744 chr13:113894564 G/T cg00898013 chr13:113819073 PROZ -0.45 -6.37 -0.33 6.54e-10 Platelet distribution width; CRC cis rs9682041 0.877 rs10804841 chr3:170072031 T/A cg11886554 chr3:170076028 SKIL 0.63 7.62 0.39 2.71e-13 Glomerular filtration rate in non diabetics (creatinine);Glomerular filtration rate (creatinine); CRC cis rs17270561 0.609 rs4711095 chr6:25726774 A/C cg16482183 chr6:26056742 HIST1H1C 0.83 10.59 0.5 9.49e-23 Iron status biomarkers; CRC cis rs10870270 1.000 rs4880246 chr10:133764064 C/T cg17892150 chr10:133769511 PPP2R2D -0.74 -10.95 -0.52 5.2e-24 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; CRC cis rs4713118 0.629 rs172165 chr6:28020814 T/G cg12172441 chr6:28176163 NA 0.54 6.99 0.36 1.58e-11 Parkinson's disease; CRC cis rs7705042 0.865 rs12655465 chr5:141522213 C/T cg08523384 chr5:141488047 NDFIP1 -0.31 -5.66 -0.3 3.27e-8 Asthma; CRC cis rs4713118 0.513 rs149975 chr6:27986340 G/A cg15786705 chr6:28176104 NA 0.62 8.87 0.44 4.89e-17 Parkinson's disease; CRC cis rs311392 0.967 rs4463399 chr8:55089449 T/C cg20636351 chr8:55087400 NA -0.33 -5.86 -0.31 1.11e-8 Pelvic organ prolapse (moderate/severe); CRC cis rs6951245 0.872 rs76713558 chr7:1095866 A/G cg21664854 chr7:1097933 C7orf50;GPR146 0.78 8.81 0.44 7.57e-17 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs7927771 1.000 rs12418852 chr11:47868853 C/G cg05585544 chr11:47624801 NA -0.61 -10.85 -0.51 1.22e-23 Subjective well-being; CRC cis rs427394 0.664 rs274701 chr5:6728707 C/A cg10857441 chr5:6722123 POLS -0.4 -6.18 -0.32 1.86e-9 Menopause (age at onset); CRC trans rs615632 0.570 rs17734541 chr8:9708433 A/G cg08975724 chr8:8085496 FLJ10661 0.42 6.53 0.34 2.45e-10 Neuroticism; CRC cis rs919433 0.857 rs36071109 chr2:198183191 C/A cg20885578 chr2:198174922 NA -0.39 -6.28 -0.33 1.09e-9 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC cis rs2415984 0.622 rs61993294 chr14:46932466 C/G cg14871534 chr14:47121158 RPL10L -0.43 -6.15 -0.32 2.22e-9 Number of children ever born; CRC cis rs10751667 0.666 rs10902242 chr11:949700 G/A cg06064525 chr11:970664 AP2A2 -0.31 -6.2 -0.32 1.68e-9 Alzheimer's disease (late onset); CRC cis rs1348850 0.526 rs10497504 chr2:178370040 T/C cg27490568 chr2:178487706 NA 0.62 7.6 0.39 3.21e-13 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs2019137 0.936 rs902696 chr2:113954879 G/T cg21550016 chr2:113992930 PAX8;LOC440839;LOC654433 0.5 7.15 0.37 5.79e-12 Lymphocyte counts; CRC cis rs9322193 0.923 rs9371199 chr6:150138662 A/T cg07701084 chr6:150067640 NUP43 0.59 8.09 0.41 1.16e-14 Lung cancer; CRC cis rs2282802 0.685 rs6580515 chr5:139698110 A/C cg26211634 chr5:139558579 C5orf32 -0.43 -7.11 -0.36 7.38e-12 Intelligence (multi-trait analysis); CRC cis rs6933660 0.800 rs6931104 chr6:151786177 C/T cg10883421 chr6:151773342 RMND1;C6orf211 0.76 13.54 0.6 1.63e-33 Menarche (age at onset); CRC cis rs2625529 0.775 rs16956273 chr15:72117102 C/T cg16672083 chr15:72433130 SENP8 -0.44 -6.32 -0.33 8.57e-10 Red blood cell count; CRC trans rs9929218 0.551 rs3785133 chr16:68728611 C/T cg04657470 chr2:198365150 HSPE1;HSPD1 1.06 21.5 0.76 1.18e-64 Colorectal cancer; CRC cis rs2153535 0.580 rs2143354 chr6:8517907 G/A cg07606381 chr6:8435919 SLC35B3 0.66 10.74 0.51 2.78e-23 Motion sickness; CRC cis rs883565 0.684 rs811971 chr3:39168283 C/T cg01426195 chr3:39028469 NA -0.4 -5.94 -0.31 7.06e-9 Handedness; CRC cis rs10504229 0.683 rs17194487 chr8:58104912 C/T cg24829409 chr8:58192753 C8orf71 -0.68 -8.48 -0.42 7.63e-16 Developmental language disorder (linguistic errors); CRC trans rs11039798 0.588 rs6485891 chr11:48612024 T/A cg03929089 chr4:120376271 NA 0.68 7.24 0.37 3.18e-12 Axial length; CRC cis rs6088580 0.634 rs4911418 chr20:32994257 G/A cg08999081 chr20:33150536 PIGU -0.61 -11.54 -0.54 4.11e-26 Glomerular filtration rate (creatinine); CRC cis rs3096299 0.642 rs12934829 chr16:89523349 T/A cg02187348 chr16:89574699 SPG7 0.39 5.75 0.3 2.01e-8 Multiple myeloma (IgH translocation); CRC cis rs59104589 0.617 rs62186409 chr2:242235710 C/A cg19488206 chr2:242435732 STK25 0.47 6.43 0.33 4.43e-10 Fibrinogen levels; CRC cis rs282587 0.569 rs282601 chr13:113392619 A/G cg04656015 chr13:113407548 ATP11A 0.63 7.79 0.39 8.78e-14 Glycated hemoglobin levels; CRC cis rs73206853 0.841 rs73206845 chr12:110660556 T/C cg12870014 chr12:110450643 ANKRD13A 0.8 7.8 0.39 8.42e-14 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC cis rs751728 0.687 rs4711355 chr6:33759906 G/T cg25922239 chr6:33757077 LEMD2 0.46 6.8 0.35 4.81e-11 Crohn's disease; CRC cis rs6121246 0.821 rs6119718 chr20:30331074 A/G cg13852791 chr20:30311386 BCL2L1 0.67 10.95 0.52 5.48e-24 Mean corpuscular hemoglobin; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg04529602 chr19:14228303 PRKACA 0.43 6.21 0.32 1.58e-9 Intelligence (multi-trait analysis); CRC cis rs11997175 0.624 rs4526317 chr8:33682936 T/A ch.8.33884649F chr8:33765107 NA 0.43 6.19 0.32 1.79e-9 Body mass index; CRC cis rs9311676 0.656 rs4399910 chr3:58389809 A/G cg06643156 chr3:58380774 PXK 0.41 6.33 0.33 7.82e-10 Systemic lupus erythematosus; CRC cis rs4481887 1.000 rs4579792 chr1:248463742 C/T cg13385794 chr1:248469461 NA -0.34 -5.84 -0.31 1.24e-8 Common traits (Other); CRC cis rs2708240 0.689 rs2710114 chr7:147598021 A/G cg02373104 chr7:147601429 MIR548F3;CNTNAP2 -0.41 -5.99 -0.31 5.52e-9 QT interval (drug interaction); CRC cis rs7149337 0.752 rs8021773 chr14:51691528 C/T cg23942311 chr14:51606299 NA 0.7 12.13 0.56 3.16e-28 Cancer; CRC cis rs3008870 1.000 rs2985795 chr1:67426223 A/G cg08660285 chr1:67390436 MIER1;WDR78 1.01 14.84 0.63 1.66e-38 Lymphocyte percentage of white cells; CRC trans rs7618501 0.602 rs9311446 chr3:50092226 G/A cg21665057 chr3:196295764 WDR53;FBXO45 -0.61 -9.68 -0.47 1.13e-19 Intelligence (multi-trait analysis); CRC trans rs747782 0.585 rs1604655 chr11:48274778 G/A cg27395922 chr11:50257633 LOC441601 0.48 6.15 0.32 2.26e-9 Intraocular pressure; CRC cis rs3924048 0.559 rs6541037 chr1:12626155 A/G cg23650765 chr1:12612165 NA 0.31 5.95 0.31 6.91e-9 Optic cup area; CRC trans rs7267979 0.966 rs2261785 chr20:25262403 C/T cg17903999 chr18:56338584 MALT1 -0.4 -6.69 -0.35 9.69e-11 Liver enzyme levels (alkaline phosphatase); CRC cis rs589448 0.933 rs523398 chr12:69752775 C/T cg20891283 chr12:69753455 YEATS4 0.99 21.36 0.76 4.12e-64 Cerebrospinal fluid biomarker levels; CRC cis rs7474896 0.616 rs1985260 chr10:38434090 C/T cg25427524 chr10:38739819 LOC399744 -0.52 -5.67 -0.3 3.16e-8 Obesity (extreme); CRC cis rs870825 0.929 rs72689262 chr4:185590950 C/G cg04058563 chr4:185651563 MLF1IP 0.56 5.89 0.31 9.54e-9 Blood protein levels; CRC cis rs738322 0.600 rs4821751 chr22:38564457 T/C cg25457927 chr22:38595422 NA -0.34 -6.92 -0.36 2.4e-11 Cutaneous nevi; CRC trans rs3733585 0.605 rs4235355 chr4:10123078 C/A cg26043149 chr18:55253948 FECH -0.55 -7.79 -0.39 8.98e-14 Cleft plate (environmental tobacco smoke interaction); CRC trans rs10411161 1.000 rs8108477 chr19:52364902 C/T cg22319618 chr22:45562946 NUP50 -0.52 -6.05 -0.32 3.84e-9 Breast cancer; CRC cis rs2303759 0.918 rs8107548 chr19:49870643 T/C cg22133161 chr19:49891603 CCDC155 0.53 7.17 0.37 4.85e-12 Multiple sclerosis; CRC cis rs6762477 0.748 rs2073726 chr3:50223593 T/A cg24110177 chr3:50126178 RBM5 0.43 6.52 0.34 2.58e-10 Menarche (age at onset); CRC cis rs10504229 0.683 rs56208052 chr8:58130207 A/T cg02725872 chr8:58115012 NA -0.64 -11.55 -0.54 3.85e-26 Developmental language disorder (linguistic errors); CRC cis rs72634258 0.842 rs4325151 chr1:8168917 T/A cg00042356 chr1:8021962 PARK7 -0.53 -6.21 -0.32 1.63e-9 Inflammatory bowel disease; CRC cis rs6860806 0.507 rs273917 chr5:131659618 A/G cg20512303 chr5:131592959 PDLIM4 0.42 7.23 0.37 3.37e-12 Breast cancer; CRC cis rs921968 0.643 rs2556386 chr2:219534530 C/T cg02176678 chr2:219576539 TTLL4 -0.48 -7.68 -0.39 1.89e-13 Mean corpuscular hemoglobin concentration; CRC cis rs72781680 0.898 rs116113042 chr2:23960194 G/T cg08917208 chr2:24149416 ATAD2B 0.86 8.45 0.42 9.69e-16 Lymphocyte counts; CRC cis rs769267 0.895 rs1000237 chr19:19518316 T/A cg02546618 chr19:19431379 KIAA0892;SF4 0.45 6.31 0.33 9.14e-10 Tonsillectomy; CRC cis rs76878669 0.561 rs2279862 chr11:66135179 C/T cg18002602 chr11:66138449 SLC29A2 0.28 6.07 0.32 3.46e-9 Educational attainment (years of education); CRC cis rs60843830 0.661 rs62116682 chr2:104618 C/T cg00108164 chr2:264199 ACP1;SH3YL1 0.41 5.75 0.3 2.08e-8 Spherical equivalent (joint analysis main effects and education interaction); CRC cis rs7904368 0.806 rs12242261 chr10:16872929 T/C cg14835575 chr10:16859367 RSU1 0.5 6.64 0.34 1.29e-10 Ratio of the peak velocity of the mitral E-Wave divided by the peak velocity of the mitral A-wave.; CRC cis rs11123170 0.529 rs1015755 chr2:113968307 G/A cg11763394 chr2:113992921 PAX8;LOC440839;LOC654433 0.51 5.95 0.31 6.86e-9 Renal function-related traits (BUN); CRC cis rs875971 0.895 rs12698520 chr7:65918707 C/A cg18876405 chr7:65276391 NA 0.52 8.85 0.44 5.68e-17 Aortic root size; CRC trans rs57221529 0.600 rs11750269 chr5:666270 G/A cg11887960 chr12:57824829 NA 0.68 7.14 0.37 6.05e-12 Lung disease severity in cystic fibrosis; CRC cis rs933688 1.000 rs6866191 chr5:90746852 G/A cg02339078 chr5:90679543 LOC100129716;ARRDC3 0.89 13.76 0.6 2.48e-34 Smoking behavior; CRC cis rs9322193 0.884 rs880245 chr6:150167398 A/G cg00933542 chr6:150070202 PCMT1 -0.32 -6.18 -0.32 1.94e-9 Lung cancer; CRC cis rs9902453 0.704 rs1972305 chr17:28533880 T/C cg26525008 chr17:28256777 EFCAB5;SSH2 0.51 7.48 0.38 6.8e-13 Coffee consumption (cups per day); CRC cis rs7552404 0.727 rs11161626 chr1:76260837 C/T cg03433033 chr1:76189801 ACADM 0.69 9.01 0.44 1.75e-17 Blood metabolite levels;Acylcarnitine levels; CRC cis rs742320 0.756 rs4984925 chr16:839996 T/C cg02106180 chr16:845767 CHTF18 0.57 9.13 0.45 7.36e-18 Mean corpuscular volume; CRC cis rs3768617 0.706 rs4129858 chr1:183004334 A/G ch.1.3577855R chr1:183094577 LAMC1 0.63 9.6 0.47 2.17e-19 Fuchs's corneal dystrophy; CRC cis rs929354 0.772 rs1182441 chr7:157026650 A/G cg16102536 chr7:156981717 UBE3C -0.4 -6.8 -0.35 4.8e-11 Body mass index; CRC cis rs2276314 0.857 rs7237599 chr18:33639396 T/C cg05985134 chr18:33552581 C18orf21 0.52 7.47 0.38 7.14e-13 Endometriosis;Drug-induced torsades de pointes; CRC cis rs55788414 0.932 rs9921748 chr16:81181783 T/C cg06400318 chr16:81190750 PKD1L2 -0.59 -6.78 -0.35 5.73e-11 Left ventricular obstructive tract defect (maternal effect); CRC cis rs2292864 0.764 rs1969269 chr17:45335537 C/A cg18085866 chr17:45331354 ITGB3 -0.64 -6.08 -0.32 3.3e-9 Left atrial antero-posterior diameter; CRC cis rs6582630 0.502 rs11520261 chr12:38332019 T/G cg26384229 chr12:38710491 ALG10B 0.67 9.78 0.47 5.53e-20 Drug-induced liver injury (flucloxacillin); CRC trans rs11039798 0.614 rs11039954 chr11:48741818 A/G cg03929089 chr4:120376271 NA 0.63 6.06 0.32 3.73e-9 Axial length; CRC cis rs9733 0.621 rs932054 chr1:150539867 C/G cg18016565 chr1:150552671 MCL1 -0.47 -7.2 -0.37 4.11e-12 Tonsillectomy; CRC cis rs10504229 0.593 rs78459635 chr8:58004995 G/T cg20607798 chr8:58055168 NA 0.5 5.77 0.3 1.84e-8 Developmental language disorder (linguistic errors); CRC cis rs28386778 0.897 rs968719 chr17:61908271 C/T cg11494091 chr17:61959527 GH2 0.68 11.07 0.52 1.95e-24 Prudent dietary pattern; CRC cis rs2522056 1.000 rs2057655 chr5:131807624 A/G cg11843238 chr5:131593191 PDLIM4 0.35 5.61 0.3 4.3e-8 Lymphocyte counts;Fibrinogen; CRC cis rs644799 1.000 rs557079 chr11:95530125 C/G cg03916912 chr11:95522834 CEP57;FAM76B 0.95 18.07 0.71 3.39e-51 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs3858526 0.727 rs10769353 chr11:5954809 C/T cg26762873 chr11:5879799 OR52E8 0.38 6.1 0.32 2.91e-9 DNA methylation (variation); CRC cis rs68170813 0.523 rs4730241 chr7:107057361 G/A cg02696742 chr7:106810147 HBP1 -0.6 -6.4 -0.33 5.25e-10 Coronary artery disease; CRC cis rs2860975 0.501 rs602941 chr10:96961184 G/A cg09036531 chr10:96991505 NA -0.73 -10.84 -0.51 1.26e-23 Immune response to smallpox vaccine (IL-6); CRC cis rs3749237 0.595 rs10865955 chr3:49499829 G/A cg02487422 chr3:49467188 NICN1 0.43 6.87 0.35 3.18e-11 Resting heart rate; CRC cis rs8031584 0.918 rs61997138 chr15:31270776 C/T cg08109568 chr15:31115862 NA -0.53 -8.62 -0.43 2.95e-16 Huntington's disease progression; CRC trans rs79976124 0.879 rs10944856 chr6:66636960 G/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.77 9.59 0.47 2.32e-19 Type 2 diabetes; CRC cis rs7959452 0.590 rs11177643 chr12:69785712 T/G cg22834771 chr12:69754056 YEATS4 -0.54 -8.12 -0.41 9.54e-15 Blood protein levels; CRC cis rs6735179 0.688 rs2382564 chr2:1763701 A/G cg19300414 chr2:1746591 PXDN 0.35 6.15 0.32 2.22e-9 Response to antipsychotic treatment; CRC cis rs780096 0.506 rs2950834 chr2:27627366 G/A cg12000995 chr2:27665139 KRTCAP3 -0.3 -6.34 -0.33 7.78e-10 Total body bone mineral density; CRC cis rs9487051 0.836 rs9487036 chr6:109607449 C/T cg01475377 chr6:109611718 NA -0.49 -9.29 -0.46 2.13e-18 Reticulocyte fraction of red cells; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg00006032 chr14:66974439 GPHN 0.44 6.25 0.33 1.29e-9 Response to antipsychotic treatment; CRC cis rs763014 1.000 rs763014 chr16:675680 T/C cg08989290 chr16:615782 NHLRC4 0.48 9.21 0.45 3.88e-18 Height; CRC cis rs13191362 1.000 rs13215491 chr6:163010325 T/C cg23758597 chr6:163146217 PARK2 -0.55 -6.12 -0.32 2.7e-9 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs9611565 0.918 rs9538 chr22:41755857 G/T cg03806693 chr22:41940476 POLR3H -1.02 -13.01 -0.58 1.61e-31 Vitiligo; CRC cis rs2882667 0.754 rs11746434 chr5:138435303 A/G cg09476006 chr5:138032270 NA 0.43 6.5 0.34 3.03e-10 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs11212617 0.905 rs425538 chr11:108219339 C/A cg01991180 chr11:108092276 ATM;NPAT 0.41 5.92 0.31 8.19e-9 Response to metformin in type 2 diabetes (glycemic); CRC cis rs802075 1.000 rs802070 chr6:49656358 A/G cg20364632 chr6:49636226 NA -0.37 -5.95 -0.31 6.7e-9 Bone mineral density (hip) and age at menarche; CRC cis rs45509595 0.841 rs200501 chr6:27788942 C/T cg26587870 chr6:27730563 NA -0.6 -5.98 -0.31 5.78e-9 Breast cancer; CRC cis rs10992471 0.580 rs10992304 chr9:95085365 G/A cg14631576 chr9:95140430 CENPP -0.4 -7.2 -0.37 4.1e-12 Visceral adipose tissue/subcutaneous adipose tissue ratio; CRC cis rs6951245 1.000 rs76833820 chr7:1070278 A/T cg20603222 chr7:1096387 C7orf50;GPR146 -0.69 -8.1 -0.41 1.07e-14 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs6582630 0.599 rs11181807 chr12:38403763 G/A cg13010199 chr12:38710504 ALG10B -0.4 -5.65 -0.3 3.44e-8 Drug-induced liver injury (flucloxacillin); CRC cis rs1881396 0.891 rs62131879 chr2:27755112 T/G cg27432699 chr2:27873401 GPN1 0.65 8.29 0.42 2.83e-15 Nonalcoholic fatty liver disease; CRC cis rs6121246 0.559 rs6060933 chr20:30351903 C/T cg13852791 chr20:30311386 BCL2L1 0.78 15.31 0.65 2.51e-40 Mean corpuscular hemoglobin; CRC cis rs10256972 0.553 rs4236381 chr7:1165723 A/C cg16145915 chr7:1198662 ZFAND2A -0.48 -9.42 -0.46 8.17e-19 Longevity;Endometriosis; CRC cis rs9388451 0.839 rs3799711 chr6:126075313 C/T cg05901451 chr6:126070800 HEY2 0.66 11.38 0.53 1.62e-25 Brugada syndrome; CRC cis rs4363385 0.747 rs1611759 chr1:152957439 T/G cg25856811 chr1:152973957 SPRR3 -0.28 -7.65 -0.39 2.18e-13 Inflammatory skin disease; CRC trans rs61931739 0.500 rs11053277 chr12:34553835 T/A cg26384229 chr12:38710491 ALG10B 0.6 8.84 0.44 5.75e-17 Morning vs. evening chronotype; CRC cis rs12477438 0.798 rs12477754 chr2:99628073 G/A cg14399236 chr2:99771627 LIPT1;TSGA10 -0.74 -10.42 -0.5 3.73e-22 Chronic sinus infection; CRC cis rs35000415 0.938 rs12539476 chr7:128657483 T/C cg19972273 chr7:128594194 NA 0.68 6.32 0.33 8.52e-10 Systemic lupus erythematosus; CRC cis rs694739 0.734 rs663743 chr11:64107735 G/A cg02228329 chr11:64053129 BAD;GPR137 0.61 9.04 0.45 1.41e-17 Alopecia areata;Crohn's disease;Psoriasis vulgaris; CRC cis rs4803468 1.000 rs878082 chr19:41897674 G/A cg09537434 chr19:41945824 ATP5SL -0.91 -18.14 -0.71 1.81e-51 Height; CRC cis rs7662987 0.517 rs2034696 chr4:100024322 C/G cg12011299 chr4:100065546 ADH4 0.49 9.27 0.46 2.46e-18 Smoking initiation; CRC cis rs7584330 0.554 rs13392410 chr2:238430273 G/A cg14458575 chr2:238380390 NA 0.54 7.09 0.36 8.5e-12 Prostate cancer; CRC cis rs11212617 0.967 rs4237579 chr11:108279201 A/G cg14761454 chr11:108092087 ATM;NPAT 0.44 6.67 0.35 1.07e-10 Response to metformin in type 2 diabetes (glycemic); CRC cis rs1577917 1.000 rs6914463 chr6:86653415 A/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.51 -6.89 -0.36 2.82e-11 Response to antipsychotic treatment; CRC cis rs7772486 0.875 rs1331645 chr6:146398407 C/G cg23711669 chr6:146136114 FBXO30 0.63 10.79 0.51 1.96e-23 Lobe attachment (rater-scored or self-reported); CRC cis rs8060686 0.641 rs113896227 chr16:68101480 C/T cg26727032 chr16:67993705 SLC12A4 -0.57 -6.39 -0.33 5.58e-10 HDL cholesterol;Metabolic syndrome; CRC cis rs951366 0.789 rs7536483 chr1:205718858 A/T cg17178900 chr1:205818956 PM20D1 0.67 9.7 0.47 9.69e-20 Menarche (age at onset); CRC cis rs6564851 0.545 rs12149068 chr16:81252903 T/G cg00908271 chr16:81254010 PKD1L2 -0.37 -5.96 -0.31 6.32e-9 Carotenoid and tocopherol levels; CRC cis rs9462027 0.628 rs1125340 chr6:34786408 A/G cg07306190 chr6:34760872 UHRF1BP1 -0.34 -6.09 -0.32 3.16e-9 Systemic lupus erythematosus; CRC cis rs3008870 0.959 rs2985810 chr1:67376162 T/C cg08660285 chr1:67390436 MIER1;WDR78 1.06 16.4 0.67 1.4e-44 Lymphocyte percentage of white cells; CRC cis rs1552244 1.000 rs113134644 chr3:10086286 G/A cg18598329 chr3:10140678 FANCD2;C3orf24 -0.9 -12.79 -0.58 1.13e-30 Alzheimer's disease; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg21411757 chr12:93771484 NUDT4;NUDT4P1 0.48 6.17 0.32 1.99e-9 Thyroid stimulating hormone; CRC trans rs10242455 0.571 rs45532337 chr7:99310319 A/G cg09045935 chr12:6379348 NA 0.78 6.48 0.34 3.42e-10 Blood metabolite levels; CRC cis rs1570884 0.516 rs7334387 chr13:50172133 T/A cg03651054 chr13:50194643 NA 0.35 7.08 0.36 8.53e-12 Sum basophil neutrophil counts;Sum neutrophil eosinophil counts;Neutrophil count;Myeloid white cell count;Granulocyte count; CRC cis rs7762018 0.891 rs73242950 chr6:170144737 C/T cg24289452 chr6:170231220 NA -0.57 -6.39 -0.33 5.75e-10 Thiazide-induced adverse metabolic effects in hypertensive patients; CRC cis rs7959452 0.535 rs7308481 chr12:69659299 A/G cg22834771 chr12:69754056 YEATS4 -0.41 -5.9 -0.31 9.25e-9 Blood protein levels; CRC cis rs7524258 1.000 rs7524258 chr1:7292229 T/C cg07173049 chr1:7289937 CAMTA1 0.53 8.51 0.42 6.44e-16 Tourette's syndrome or obsessive-compulsive disorder; CRC cis rs7811142 0.830 rs11761426 chr7:99956893 A/T cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.61 7.95 0.4 3e-14 Platelet count; CRC cis rs4713118 0.629 rs203889 chr6:28021775 T/G cg12273811 chr6:28175739 NA 0.63 8.63 0.43 2.64e-16 Parkinson's disease; CRC trans rs7613875 0.600 rs2624848 chr3:50165101 T/C cg21665057 chr3:196295764 WDR53;FBXO45 -0.47 -6.89 -0.36 2.92e-11 Body mass index; CRC cis rs12044355 0.927 rs17748239 chr1:231834901 A/G cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.5 -6.81 -0.35 4.68e-11 Alzheimer's disease; CRC trans rs875971 0.545 rs7810213 chr7:65946579 G/C cg02869306 chr7:64672164 INTS4L1 -0.43 -6.11 -0.32 2.88e-9 Aortic root size; CRC cis rs4665809 1.000 rs4665305 chr2:26313524 C/T cg27170947 chr2:26402098 FAM59B -0.45 -6.16 -0.32 2.13e-9 Gut microbiome composition (summer); CRC cis rs910187 0.678 rs3818008 chr20:45816488 C/T cg27589058 chr20:45804311 EYA2 -0.37 -7.12 -0.37 6.7e-12 Migraine; CRC cis rs4713118 0.868 rs35069907 chr6:27746692 T/C cg25164649 chr6:28176230 NA 0.67 7.56 0.38 4.17e-13 Parkinson's disease; CRC trans rs9467711 0.606 rs34104395 chr6:26478252 C/T cg06606381 chr12:133084897 FBRSL1 -1.08 -7.35 -0.38 1.62e-12 Autism spectrum disorder or schizophrenia; CRC cis rs9467773 0.935 rs1056668 chr6:26510605 C/T cg09904177 chr6:26538194 HMGN4 0.73 11.26 0.53 4.43e-25 Intelligence (multi-trait analysis); CRC cis rs2257205 0.667 rs8070007 chr17:56709169 A/G cg25885038 chr17:56607967 SEPT4 -0.53 -5.79 -0.3 1.62e-8 Pancreatic cancer; CRC cis rs7680126 0.633 rs2868937 chr4:10303081 C/T cg00071950 chr4:10020882 SLC2A9 -0.51 -6.58 -0.34 1.82e-10 Urate levels in lean individuals;Urate levels in overweight individuals;Urate levels in obese individuals; CRC cis rs600806 0.850 rs11102976 chr1:109917540 G/C cg23032129 chr1:109941072 SORT1 -0.27 -5.84 -0.31 1.24e-8 Intelligence (multi-trait analysis); CRC cis rs3741404 0.825 rs2515241 chr11:63975331 C/T cg19465662 chr11:63993652 NUDT22;TRPT1 0.83 13.81 0.61 1.55e-34 Platelet count; CRC trans rs7615952 0.512 rs1077621 chr3:125819799 A/G cg07211511 chr3:129823064 LOC729375 -0.69 -9.02 -0.45 1.65e-17 Blood pressure (smoking interaction); CRC trans rs4869931 0.929 rs59466561 chr6:151005119 C/T cg01367992 chr1:160766535 LY9 0.37 6.03 0.32 4.38e-9 Systolic blood pressure in sickle cell anemia; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg05002732 chr11:19262474 E2F8 0.42 6.03 0.32 4.5e-9 Intelligence (multi-trait analysis); CRC cis rs1707322 1.000 rs6429588 chr1:46454058 T/G cg06784218 chr1:46089804 CCDC17 0.52 9.19 0.45 4.43e-18 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC trans rs916888 0.773 rs199447 chr17:44812188 C/T cg22968622 chr17:43663579 NA 1.45 19.88 0.74 2.43e-58 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs9322193 0.923 rs17745062 chr6:150042215 T/A cg05861140 chr6:150128134 PCMT1 -0.37 -5.96 -0.31 6.32e-9 Lung cancer; CRC cis rs3796619 0.503 rs1466216 chr4:1071907 C/T cg13468214 chr4:1046988 NA 0.34 5.78 0.3 1.72e-8 Recombination rate (males); CRC cis rs13064447 0.817 rs73022939 chr3:12762264 G/A cg07775309 chr3:12595852 NA 0.37 5.94 0.31 7.18e-9 Major depression and alcohol dependence; CRC cis rs7811142 0.830 rs7792959 chr7:99972403 C/T cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.61 8.02 0.4 1.83e-14 Platelet count; CRC cis rs72781680 0.848 rs56371415 chr2:23932603 C/G cg08917208 chr2:24149416 ATAD2B 0.96 8.95 0.44 2.58e-17 Lymphocyte counts; CRC cis rs9487051 0.836 rs9487036 chr6:109607449 C/T cg21918786 chr6:109611834 NA -0.45 -8.24 -0.41 4.21e-15 Reticulocyte fraction of red cells; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg13906749 chr12:120933893 DYNLL1 -0.42 -6.31 -0.33 8.95e-10 Myopia (pathological); CRC cis rs172166 0.637 rs1225595 chr6:28151340 A/T cg02683197 chr6:28174875 NA 0.75 11.02 0.52 3.04e-24 Cardiac Troponin-T levels; CRC cis rs6963495 0.745 rs2392749 chr7:105182605 A/G cg13798780 chr7:105162888 PUS7 0.42 5.67 0.3 3.15e-8 Bipolar disorder (body mass index interaction); CRC cis rs7617773 0.780 rs36121690 chr3:48345511 C/T cg11946769 chr3:48343235 NME6 0.73 9.69 0.47 1.03e-19 Coronary artery disease; CRC cis rs2180341 0.924 rs877661 chr6:127587915 T/G cg24812749 chr6:127587940 RNF146 0.93 13.32 0.59 1.11e-32 Breast cancer; CRC cis rs7412746 0.634 rs12409208 chr1:150860055 A/G cg15448220 chr1:150897856 SETDB1 0.56 8.02 0.4 1.87e-14 Melanoma; CRC cis rs9443645 0.527 rs9361479 chr6:79723755 T/A cg05283184 chr6:79620031 NA -0.45 -6.43 -0.33 4.49e-10 Intelligence (multi-trait analysis); CRC cis rs873946 0.648 rs12766050 chr10:134549108 G/A cg26818010 chr10:134567672 INPP5A -0.65 -8.41 -0.42 1.28e-15 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CRC cis rs10504229 0.906 rs116341227 chr8:58190532 G/C cg02290350 chr8:58132656 NA -0.42 -5.98 -0.31 5.73e-9 Developmental language disorder (linguistic errors); CRC cis rs6973256 0.637 rs1362739 chr7:133430934 C/A cg10665199 chr7:133106180 EXOC4 0.45 7.09 0.36 8.05e-12 Intelligence (multi-trait analysis); CRC cis rs2180341 0.814 rs9385424 chr6:127726796 A/G cg24812749 chr6:127587940 RNF146 0.67 9.13 0.45 7.3e-18 Breast cancer; CRC cis rs2153535 0.580 rs4960422 chr6:8459309 T/C cg07606381 chr6:8435919 SLC35B3 0.69 11.15 0.52 1.04e-24 Motion sickness; CRC cis rs787274 0.543 rs62576453 chr9:115629921 C/T cg13803584 chr9:115635662 SNX30 -0.64 -6.57 -0.34 1.97e-10 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs798554 0.796 rs2533884 chr7:2836848 T/G cg17321639 chr7:2759063 NA -0.51 -6.7 -0.35 9.26e-11 Height; CRC cis rs4588572 0.643 rs7700390 chr5:77789532 T/C cg11547950 chr5:77652471 NA -0.57 -8.06 -0.41 1.43e-14 Triglycerides; CRC cis rs6952808 0.693 rs10950413 chr7:1912988 A/G cg20295408 chr7:1910781 MAD1L1 -0.37 -5.62 -0.3 3.99e-8 Bipolar disorder and schizophrenia; CRC cis rs8060686 0.920 rs2292318 chr16:67985706 C/T cg08314208 chr16:67682810 RLTPR -0.69 -7.43 -0.38 9.17e-13 HDL cholesterol;Metabolic syndrome; CRC cis rs1448094 0.511 rs10779207 chr12:86152913 A/G cg02569458 chr12:86230093 RASSF9 -0.48 -7.92 -0.4 3.61e-14 Major depressive disorder; CRC cis rs853679 0.517 rs4711165 chr6:28115184 T/G cg12172441 chr6:28176163 NA 0.64 7.53 0.38 5.03e-13 Depression; CRC cis rs904251 0.861 rs1757180 chr6:37486145 T/C cg01843034 chr6:37503916 NA -0.46 -8.54 -0.43 4.93e-16 Cognitive performance; CRC cis rs34779708 0.931 rs11010077 chr10:35328088 C/T cg03585969 chr10:35415529 CREM -0.57 -7.86 -0.4 5.37e-14 Inflammatory bowel disease;Crohn's disease; CRC cis rs34311866 0.808 rs3755958 chr4:963042 C/A cg14530993 chr4:882597 GAK 0.75 6.88 0.35 3.02e-11 Parkinson's disease; CRC cis rs1865760 0.613 rs9295674 chr6:25912342 A/G cg03264133 chr6:25882463 NA -0.49 -7.33 -0.37 1.81e-12 Height; CRC cis rs883565 0.569 rs7638329 chr3:39020408 T/C cg01426195 chr3:39028469 NA -0.44 -7.27 -0.37 2.58e-12 Handedness; CRC cis rs2559856 1.000 rs2251187 chr12:102081889 G/A cg12924262 chr12:102091054 CHPT1 0.56 8.35 0.42 1.97e-15 Blood protein levels; CRC cis rs2839186 0.587 rs35679325 chr21:47640980 A/G cg11766577 chr21:47581405 C21orf56 0.39 5.88 0.31 1.03e-8 Testicular germ cell tumor; CRC cis rs708547 0.575 rs6847086 chr4:57791864 A/G cg25525207 chr4:57843836 C4orf14;POLR2B 0.43 5.93 0.31 7.58e-9 Response to bleomycin (chromatid breaks); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg19875216 chr3:133524841 SRPRB 0.49 6.9 0.36 2.61e-11 Response to antipsychotic treatment; CRC cis rs2228479 1.000 rs12596492 chr16:89957169 T/G cg19635926 chr16:89946313 TCF25 0.65 6.21 0.32 1.55e-9 Skin colour saturation; CRC cis rs524281 0.731 rs10791838 chr11:65789854 T/G cg16950941 chr11:66035639 RAB1B -0.54 -5.96 -0.31 6.59e-9 Electroencephalogram traits; CRC cis rs9894429 0.809 rs9889642 chr17:79591762 T/C cg21984481 chr17:79567631 NPLOC4 -0.53 -9.8 -0.48 4.61e-20 Eye color traits; CRC cis rs265548 0.646 rs36689 chr19:17910639 A/G cg16744531 chr19:17905626 B3GNT3 0.57 9.61 0.47 2.02e-19 Tumor biomarkers; CRC cis rs13315871 0.722 rs3952239 chr3:58312057 G/T cg20936604 chr3:58311152 NA -0.75 -7.68 -0.39 1.83e-13 Cholesterol, total; CRC cis rs2439831 0.850 rs68079546 chr15:44136957 G/T cg15269541 chr15:43626905 ADAL -0.49 -5.9 -0.31 9.27e-9 Lung cancer in ever smokers; CRC cis rs936229 0.861 rs3935077 chr15:75120211 C/G cg10253484 chr15:75165896 SCAMP2 -0.41 -5.93 -0.31 7.78e-9 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); CRC cis rs7607369 0.500 rs6712856 chr2:219658617 A/T cg02176678 chr2:219576539 TTLL4 -0.45 -7.13 -0.37 6.43e-12 Red blood cell count;Amyotrophic lateral sclerosis; CRC cis rs9916302 0.904 rs12452509 chr17:37574722 G/A cg07936489 chr17:37558343 FBXL20 -0.85 -13.38 -0.59 6.93e-33 Glomerular filtration rate (creatinine); CRC cis rs60871478 1.000 rs62432251 chr7:801855 T/G cg04727924 chr7:799746 HEATR2 -0.44 -6.32 -0.33 8.53e-10 Cerebrospinal P-tau181p levels; CRC cis rs2982552 0.844 rs3020343 chr6:152054363 C/T cg22157087 chr6:152012887 ESR1 0.38 5.86 0.31 1.15e-8 Bone properties (heel); CRC cis rs13191362 1.000 rs35449999 chr6:163023465 A/G cg21926612 chr6:163149169 PACRG;PARK2 0.78 10.45 0.5 2.86e-22 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs7772486 0.686 rs4896828 chr6:145953339 A/C cg13319975 chr6:146136371 FBXO30 -0.44 -6.65 -0.34 1.26e-10 Lobe attachment (rater-scored or self-reported); CRC cis rs34172651 0.917 rs2112786 chr16:24778944 C/T cg06028605 chr16:24865363 SLC5A11 0.4 7.69 0.39 1.71e-13 Intelligence (multi-trait analysis); CRC trans rs459571 0.635 rs379471 chr9:136890649 G/A cg15028160 chr19:49622717 PPFIA3;C19orf73 -0.58 -7.34 -0.38 1.7e-12 Platelet distribution width; CRC cis rs9443645 0.901 rs1538233 chr6:79743735 G/T cg09184832 chr6:79620586 NA -0.5 -9.15 -0.45 6.08e-18 Intelligence (multi-trait analysis); CRC cis rs9372498 0.536 rs72952793 chr6:118892979 T/A cg18833306 chr6:118973337 C6orf204 0.44 5.66 0.3 3.38e-8 Diastolic blood pressure; CRC cis rs9359856 0.957 rs9362666 chr6:90310345 T/C cg13799429 chr6:90582589 CASP8AP2 0.42 6.01 0.31 5.04e-9 Bipolar disorder; CRC cis rs1862618 0.573 rs185220 chr5:56205357 A/G cg03609598 chr5:56110824 MAP3K1 -0.76 -8.73 -0.43 1.31e-16 Initial pursuit acceleration; CRC cis rs875971 1.000 rs4718344 chr7:65874381 C/A cg00343986 chr7:65444356 GUSB 0.43 6.3 0.33 9.66e-10 Aortic root size; CRC cis rs769267 0.895 rs2905435 chr19:19495954 G/A cg03709012 chr19:19516395 GATAD2A -0.72 -11.45 -0.53 8.76e-26 Tonsillectomy; CRC cis rs2032447 0.966 rs3752416 chr6:26045929 T/C cg12588279 chr6:26043732 HIST1H2BB 0.45 6.77 0.35 5.78e-11 Intelligence (multi-trait analysis); CRC cis rs7618915 0.524 rs2028216 chr3:52680823 C/T cg11645453 chr3:52864694 ITIH4 0.37 6.41 0.33 4.91e-10 Bipolar disorder; CRC cis rs853679 0.760 rs11967137 chr6:28199764 A/G cg06470822 chr6:28175283 NA 0.77 8.09 0.41 1.18e-14 Depression; CRC cis rs3617 0.625 rs2245647 chr3:52862753 A/G cg07507251 chr3:52567010 NT5DC2 0.4 6.22 0.32 1.53e-9 Red blood cell count;Autism spectrum disorder or schizophrenia; CRC cis rs2933343 0.679 rs789229 chr3:128602526 C/T cg25356066 chr3:128598488 ACAD9 0.39 5.69 0.3 2.82e-8 IgG glycosylation; CRC cis rs172166 0.637 rs1225592 chr6:28150242 G/A cg12273811 chr6:28175739 NA 0.67 10.11 0.49 4.27e-21 Cardiac Troponin-T levels; CRC cis rs910316 1.000 rs13099 chr14:75599155 G/A cg08847533 chr14:75593920 NEK9 -0.89 -16.27 -0.67 4.42e-44 Height; CRC cis rs8177253 0.665 rs7646118 chr3:133450039 C/T cg11941060 chr3:133502564 NA -0.47 -7.66 -0.39 2.05e-13 Iron status biomarkers; CRC cis rs6840360 0.571 rs11944139 chr4:152505291 T/C cg09659197 chr4:152720779 NA 0.35 6.19 0.32 1.76e-9 Intelligence (multi-trait analysis); CRC cis rs7615952 0.512 rs1077621 chr3:125819799 A/G cg06494592 chr3:125709126 NA -0.57 -6.67 -0.35 1.08e-10 Blood pressure (smoking interaction); CRC cis rs727563 0.562 rs5758458 chr22:42154132 G/A cg03806693 chr22:41940476 POLR3H 1.09 13.45 0.6 3.5e-33 Crohn's disease;Inflammatory bowel disease; CRC cis rs1448094 0.967 rs10779222 chr12:86330775 G/A cg19622623 chr12:86230825 RASSF9 -0.35 -5.69 -0.3 2.8e-8 Major depressive disorder; CRC cis rs9486715 0.929 rs7775721 chr6:97056979 C/T cg06623918 chr6:96969491 KIAA0776 -1.04 -20.43 -0.75 1.71e-60 Headache; CRC cis rs12926788 0.546 rs200537 chr16:24747787 G/C cg06505273 chr16:24850292 NA -0.52 -6.68 -0.35 1.01e-10 Ejection fraction in Tripanosoma cruzi seropositivity; CRC cis rs513349 0.964 rs210139 chr6:33543409 A/C cg24505687 chr6:33548425 BAK1 0.3 5.91 0.31 8.73e-9 Platelet count; CRC cis rs2153535 0.580 rs1414346 chr6:8471574 A/G cg21535247 chr6:8435926 SLC35B3 0.49 7.4 0.38 1.14e-12 Motion sickness; CRC cis rs4728302 0.594 rs12533206 chr7:133700251 C/T cg03336402 chr7:133662267 EXOC4 -0.51 -8.06 -0.41 1.44e-14 Intelligence;Intelligence (multi-trait analysis); CRC cis rs4718428 0.705 rs28648401 chr7:66367132 T/C cg18252515 chr7:66147081 NA -0.55 -7.66 -0.39 2.1e-13 Corneal structure; CRC cis rs7666738 0.830 rs62321598 chr4:99014237 C/T cg17366294 chr4:99064904 C4orf37 0.44 7.36 0.38 1.5e-12 Colonoscopy-negative controls vs population controls; CRC cis rs10256972 0.591 rs11766651 chr7:1161646 A/G cg23978390 chr7:1156363 C7orf50 0.55 7.59 0.39 3.25e-13 Longevity;Endometriosis; CRC cis rs6500395 0.962 rs9927888 chr16:48557764 A/T cg04672837 chr16:48644449 N4BP1 0.42 6.06 0.32 3.66e-9 Response to tocilizumab in rheumatoid arthritis; CRC cis rs8062405 1.000 rs11861174 chr16:28871989 A/G cg16576597 chr16:28551801 NUPR1 0.48 6.82 0.35 4.39e-11 Cognitive ability (multi-trait analysis);Cognitive ability; CRC cis rs13108904 0.967 rs900028 chr4:1279162 A/T cg02018176 chr4:1364513 KIAA1530 0.47 7.68 0.39 1.78e-13 Obesity-related traits; CRC cis rs28386778 0.897 rs894407 chr17:61901641 T/C cg22520471 chr17:61851767 DDX42;CCDC47 0.75 11.75 0.54 7.35e-27 Prudent dietary pattern; CRC cis rs801193 0.569 rs13242290 chr7:66121885 G/A cg11764359 chr7:65958608 NA -0.59 -8.68 -0.43 1.85e-16 Aortic root size; CRC cis rs7945718 0.622 rs4643058 chr11:12689454 C/T cg25843174 chr11:12811716 TEAD1 0.39 7.17 0.37 4.95e-12 Educational attainment (years of education); CRC cis rs4819052 0.819 rs7279136 chr21:46692287 C/T cg19498844 chr21:46707878 POFUT2;LOC642852 0.79 11.53 0.54 4.61e-26 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC trans rs11148252 1.000 rs4886018 chr13:52990717 C/T cg18335740 chr13:41363409 SLC25A15 0.52 8.35 0.42 1.93e-15 Lewy body disease; CRC cis rs514406 0.722 rs7552139 chr1:53387379 G/C cg24675658 chr1:53192096 ZYG11B -0.57 -8.4 -0.42 1.33e-15 Monocyte count; CRC cis rs951366 0.589 rs823099 chr1:205669322 C/A cg14159672 chr1:205819179 PM20D1 0.7 9.56 0.47 2.77e-19 Menarche (age at onset); CRC cis rs4555082 0.718 rs28513571 chr14:105709592 C/A cg18132624 chr14:105716052 BTBD6;BRF1 -0.48 -7.91 -0.4 3.85e-14 Mean platelet volume;Platelet distribution width; CRC cis rs7618501 0.571 rs2240329 chr3:50107512 G/A cg05623727 chr3:50126028 RBM5 -0.44 -7.39 -0.38 1.23e-12 Intelligence (multi-trait analysis); CRC cis rs2749592 0.513 rs9417249 chr10:37837155 C/T cg25427524 chr10:38739819 LOC399744 0.61 9.79 0.48 4.91e-20 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs4523957 0.819 rs12450354 chr17:2159982 C/T cg16513277 chr17:2031491 SMG6 0.53 8.76 0.43 1.07e-16 Autism spectrum disorder or schizophrenia;Schizophrenia; CRC cis rs514406 0.823 rs501006 chr1:53368292 T/A cg25767906 chr1:53392781 SCP2 -0.49 -7.85 -0.4 6e-14 Monocyte count; CRC cis rs970548 0.955 rs10900223 chr10:46021631 T/C cg15590007 chr10:45870220 ALOX5 0.5 6.38 0.33 6.07e-10 Total cholesterol levels;Cholesterol, total;HDL cholesterol;HDL cholesterol levels; CRC cis rs2857891 0.909 rs56261447 chr11:6939382 A/C cg26870460 chr11:6947759 ZNF215 0.58 6.05 0.32 3.85e-9 Response to cytadine analogues (cytosine arabinoside); CRC cis rs546131 0.928 rs535719 chr11:34853382 A/G cg24088639 chr11:34937564 PDHX;APIP -0.48 -6.74 -0.35 7.05e-11 Lung disease severity in cystic fibrosis; CRC cis rs7940866 0.903 rs7940465 chr11:130861339 C/T cg12179176 chr11:130786555 SNX19 0.56 8.27 0.41 3.46e-15 Schizophrenia; CRC cis rs910316 1.000 rs10140851 chr14:75512612 G/A cg03030879 chr14:75389066 RPS6KL1 -0.49 -7.52 -0.38 5.33e-13 Height; CRC cis rs533581 0.866 rs561795 chr16:88970818 A/G cg09141835 chr16:88988174 CBFA2T3 -0.27 -5.9 -0.31 8.91e-9 Social autistic-like traits; CRC cis rs12983728 0.831 rs79222418 chr19:58664418 T/C cg06882758 chr19:58662330 ZNF329 0.74 7.78 0.39 9.17e-14 Cholesterol, total; CRC cis rs9910055 0.664 rs433610 chr17:42197281 A/G cg10896456 chr17:42255109 ASB16;C17orf65 -0.47 -7.72 -0.39 1.43e-13 Total body bone mineral density; CRC cis rs7246967 0.673 rs7247191 chr19:22899585 C/T cg08271804 chr19:22816896 ZNF492 0.36 5.66 0.3 3.23e-8 Bronchopulmonary dysplasia; CRC cis rs4665809 1.000 rs6729080 chr2:26301282 G/A cg22920501 chr2:26401640 FAM59B -0.53 -7.23 -0.37 3.4e-12 Gut microbiome composition (summer); CRC cis rs1046896 0.561 rs8076476 chr17:80861017 A/C cg19046167 chr17:80928561 B3GNTL1 0.48 6.75 0.35 6.84e-11 Glycated hemoglobin levels; CRC cis rs936229 0.813 rs2301249 chr15:75092384 T/C cg10253484 chr15:75165896 SCAMP2 -0.4 -5.82 -0.31 1.4e-8 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); CRC cis rs8010715 0.804 rs1134334 chr14:24594114 A/G cg23112188 chr14:24563095 PCK2 -0.36 -7.02 -0.36 1.29e-11 IgG glycosylation; CRC cis rs10795061 0.576 rs12219804 chr10:3710626 C/T cg22632523 chr10:3711048 NA 0.45 6.24 0.33 1.35e-9 Subjective well-being; CRC cis rs7249142 0.526 rs7256811 chr19:19283551 A/G cg08207377 chr19:19281140 LOC729991-MEF2B;MEF2B -0.38 -6.18 -0.32 1.92e-9 IgG glycosylation; CRC cis rs300703 0.542 rs189762 chr2:180079 A/T cg21211680 chr2:198530 NA -0.75 -9.37 -0.46 1.18e-18 Blood protein levels; CRC cis rs7605378 1.000 rs769957 chr2:200695524 A/C cg23649088 chr2:200775458 C2orf69 0.59 8.33 0.42 2.27e-15 Osteoporosis; CRC cis rs4727027 0.901 rs1137432 chr7:148801658 C/T cg23583168 chr7:148888333 NA -0.88 -14.91 -0.63 9.26e-39 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC trans rs6600671 1.000 rs7532615 chr1:121172840 G/T cg00646200 chr1:148855367 NA -0.35 -6.38 -0.33 5.95e-10 Hip geometry; CRC cis rs1008375 0.966 rs2315553 chr4:17627332 T/C cg16339924 chr4:17578868 LAP3 0.55 7.3 0.37 2.17e-12 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs7618915 0.501 rs35526119 chr3:52749334 C/T cg11645453 chr3:52864694 ITIH4 0.37 6.53 0.34 2.57e-10 Bipolar disorder; CRC cis rs3785574 0.962 rs2665840 chr17:61873307 C/T cg06601766 chr17:61851465 DDX42;CCDC47 -0.58 -8.26 -0.41 3.67e-15 Height; CRC cis rs7618501 0.602 rs2071206 chr3:50160109 G/A cg24110177 chr3:50126178 RBM5 0.51 7.92 0.4 3.71e-14 Intelligence (multi-trait analysis); CRC cis rs1552244 0.572 rs113406084 chr3:10170190 T/C cg08888203 chr3:10149979 C3orf24 0.71 8.58 0.43 3.91e-16 Alzheimer's disease; CRC cis rs2046867 0.818 rs6786469 chr3:72873809 A/G cg25664220 chr3:72788482 NA -0.43 -6.33 -0.33 7.96e-10 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; CRC cis rs2732480 0.577 rs2732481 chr12:48736985 T/G cg04545296 chr12:48745243 ZNF641 0.36 6.19 0.32 1.81e-9 Hemoglobin concentration;Red blood cell count;Hematocrit; CRC cis rs11785400 0.928 rs10100287 chr8:143734836 C/T cg24634471 chr8:143751801 JRK 0.5 7.09 0.36 8.42e-12 Schizophrenia; CRC trans rs7267979 0.932 rs6138600 chr20:25521346 A/T cg17903999 chr18:56338584 MALT1 -0.42 -6.87 -0.35 3.17e-11 Liver enzyme levels (alkaline phosphatase); CRC cis rs7208859 0.623 rs3752021 chr17:29111043 G/C cg13385521 chr17:29058706 SUZ12P 0.73 8.33 0.42 2.14e-15 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs6123683 0.702 rs1998190 chr20:55822649 A/C cg13236649 chr20:55835020 BMP7 -0.45 -7.05 -0.36 1.08e-11 Facial morphology (factor 5, width of mouth relative to central midface); CRC cis rs8060686 0.920 rs58588228 chr16:67802010 C/T cg26727032 chr16:67993705 SLC12A4 -0.6 -6.97 -0.36 1.69e-11 HDL cholesterol;Metabolic syndrome; CRC trans rs1814175 0.817 rs10839465 chr11:49981554 C/A cg03929089 chr4:120376271 NA -0.98 -19.36 -0.73 2.81e-56 Height; CRC cis rs4988958 0.565 rs885088 chr2:103039044 A/G cg03938978 chr2:103052716 IL18RAP 0.6 10.39 0.5 4.55e-22 Asthma (childhood onset); CRC cis rs79349575 0.783 rs318090 chr17:46991752 G/A cg00947319 chr17:47005597 UBE2Z -0.34 -5.87 -0.31 1.07e-8 Type 2 diabetes; CRC cis rs3096299 0.685 rs4785675 chr16:89539974 T/C cg08392591 chr16:89556376 ANKRD11 0.43 5.93 0.31 7.62e-9 Multiple myeloma (IgH translocation); CRC cis rs10191773 0.589 rs72831639 chr2:112949291 A/G cg24977338 chr2:113188963 RGPD8;RGPD5 -0.67 -5.74 -0.3 2.17e-8 Yeast infection; CRC cis rs769267 0.965 rs2965191 chr19:19453521 T/G cg02546618 chr19:19431379 KIAA0892;SF4 -0.46 -6.46 -0.34 3.86e-10 Tonsillectomy; CRC cis rs780096 0.545 rs2280737 chr2:27589810 A/G cg27432699 chr2:27873401 GPN1 -0.5 -7.67 -0.39 2e-13 Total body bone mineral density; CRC cis rs2380220 0.606 rs9488080 chr6:96006973 A/G cg15832292 chr6:96025679 MANEA 0.65 7.81 0.4 7.91e-14 Behavioural disinhibition (generation interaction); CRC cis rs9814567 0.752 rs7633868 chr3:134331048 A/G cg06109529 chr3:134205091 CEP63;ANAPC13 -0.67 -9.64 -0.47 1.61e-19 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs3806843 1.000 rs10057161 chr5:140156831 C/T cg16607685 chr5:140181889 PCDHA2;PCDHA1;PCDHA3 -0.25 -5.83 -0.31 1.32e-8 Depressive symptoms (multi-trait analysis); CRC trans rs11764590 0.666 rs3996325 chr7:2053747 T/C cg11693508 chr17:37793320 STARD3 0.54 7.06 0.36 1.02e-11 Neuroticism; CRC cis rs941873 0.868 rs2181080 chr10:81121960 A/G cg09469691 chr10:81107165 PPIF 0.57 9.15 0.45 6.06e-18 Height; CRC cis rs4664293 0.867 rs3863924 chr2:160614758 A/T cg08347373 chr2:160653686 CD302 -0.47 -7.43 -0.38 9.32e-13 Monocyte percentage of white cells; CRC trans rs12699921 0.632 rs2723572 chr7:17888587 T/C cg15753394 chr6:17282781 RBM24 -0.37 -6.17 -0.32 1.96e-9 Fibrinogen levels; CRC cis rs6963495 0.818 rs73192107 chr7:105168095 G/A cg13798780 chr7:105162888 PUS7 0.68 8.04 0.41 1.59e-14 Bipolar disorder (body mass index interaction); CRC cis rs35146811 0.961 rs11771139 chr7:99736059 C/T cg00553149 chr7:99775558 STAG3;GPC2 0.25 5.89 0.31 9.29e-9 Coronary artery disease; CRC cis rs10208940 0.764 rs7583649 chr2:68830939 T/C cg12452813 chr2:68675892 NA 0.49 6.09 0.32 3.2e-9 Urate levels in lean individuals; CRC cis rs763014 0.932 rs2384974 chr16:651279 C/G cg02475695 chr16:616220 NHLRC4 0.47 7.87 0.4 5.3e-14 Height; CRC cis rs7666738 0.830 rs1025203 chr4:99023073 G/A cg05340658 chr4:99064831 C4orf37 0.6 9.18 0.45 5.08e-18 Colonoscopy-negative controls vs population controls; CRC cis rs1218582 0.741 rs10908444 chr1:154840287 G/A cg09359103 chr1:154839909 KCNN3 -0.75 -13.79 -0.61 1.84e-34 Prostate cancer; CRC cis rs9534288 0.797 rs4142548 chr13:46535350 A/G cg15192986 chr13:46630673 CPB2 -0.64 -9.35 -0.46 1.38e-18 Blood protein levels; CRC cis rs55871839 0.684 rs9298002 chr8:59815118 T/C cg07426533 chr8:59803705 TOX -0.34 -5.86 -0.31 1.13e-8 Pneumonia; CRC cis rs77633900 0.614 rs2439989 chr15:76883862 G/C cg21673338 chr15:77095150 SCAPER -0.72 -7.05 -0.36 1.07e-11 Non-glioblastoma glioma;Glioma; CRC cis rs7937682 0.847 rs500163 chr11:111462649 T/G cg09085632 chr11:111637200 PPP2R1B -0.94 -17.74 -0.7 7.01e-50 Primary sclerosing cholangitis; CRC cis rs56114371 0.530 rs169262 chr6:27770890 C/T cg26587870 chr6:27730563 NA -0.5 -6.87 -0.35 3.14e-11 Breast cancer; CRC cis rs11229555 0.645 rs12226725 chr11:58246332 G/A cg15696309 chr11:58395628 NA -0.89 -11.6 -0.54 2.61e-26 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; CRC cis rs6681460 1.000 rs10789210 chr1:67066030 G/A cg02459107 chr1:67143332 SGIP1 0.47 8.18 0.41 6.4e-15 Presence of antiphospholipid antibodies; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg17517709 chr10:18999145 NA 0.44 7.0 0.36 1.47e-11 Liver disease severity in Alagille syndrome; CRC cis rs6546550 0.901 rs7573442 chr2:70154037 G/A cg02498382 chr2:70120550 SNRNP27 -0.55 -9.39 -0.46 1.02e-18 Prevalent atrial fibrillation; CRC cis rs807669 0.903 rs756651 chr22:19179367 T/C cg02655711 chr22:19163373 SLC25A1 0.98 19.99 0.74 9.58e-59 Metabolite levels; CRC cis rs8014204 1.000 rs8014204 chr14:75322794 A/G cg03030879 chr14:75389066 RPS6KL1 -0.52 -8.36 -0.42 1.78e-15 Caffeine consumption; CRC cis rs4713118 0.869 rs9393851 chr6:27699581 A/T cg12172441 chr6:28176163 NA 0.52 7.19 0.37 4.51e-12 Parkinson's disease; CRC cis rs6089584 0.546 rs6061978 chr20:60615604 C/T cg13770153 chr20:60521292 NA -0.41 -6.17 -0.32 2.04e-9 Body mass index; CRC cis rs2739330 0.828 rs4822454 chr22:24255208 G/A cg10819733 chr22:24237672 NA -0.35 -6.12 -0.32 2.63e-9 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs7647973 0.600 rs11920267 chr3:49275964 G/A cg03060546 chr3:49711283 APEH 0.46 6.68 0.35 1.02e-10 Menarche (age at onset); CRC cis rs13315871 0.929 rs35007301 chr3:58230352 G/A cg20936604 chr3:58311152 NA -0.68 -6.59 -0.34 1.75e-10 Cholesterol, total; CRC cis rs172166 0.561 rs149974 chr6:27985096 T/C cg02683197 chr6:28174875 NA 0.46 6.38 0.33 6.1e-10 Cardiac Troponin-T levels; CRC cis rs35306767 0.903 rs35637113 chr10:874149 G/C cg20503657 chr10:835505 NA 0.94 11.39 0.53 1.51e-25 Eosinophil percentage of granulocytes; CRC cis rs9807841 0.592 rs3810154 chr19:10764914 G/A cg17710535 chr19:10819994 QTRT1 0.44 6.54 0.34 2.3e-10 Inflammatory skin disease; CRC cis rs4453791 0.769 rs4676585 chr3:38951040 A/T cg02254461 chr3:39195904 CSRNP1 0.45 5.74 0.3 2.16e-8 Social communication problems; CRC cis rs360798 0.512 rs2710642 chr2:63149557 G/A cg17519650 chr2:63277830 OTX1 0.49 6.85 0.35 3.61e-11 Coronary artery disease; CRC trans rs9929218 0.551 rs8051095 chr16:68722049 G/A cg04657470 chr2:198365150 HSPE1;HSPD1 1.22 32.66 0.87 3.02e-105 Colorectal cancer; CRC cis rs16852403 0.583 rs964993 chr1:178062359 G/A cg00404053 chr1:178313656 RASAL2 0.62 7.93 0.4 3.56e-14 Childhood ear infection; CRC cis rs7586879 0.593 rs6733224 chr2:25130907 C/T cg04586622 chr2:25135609 ADCY3 0.55 10.34 0.5 6.73e-22 Body mass index; CRC cis rs7618501 0.633 rs11130228 chr3:50003246 C/T cg05623727 chr3:50126028 RBM5 0.45 7.6 0.39 3.11e-13 Intelligence (multi-trait analysis); CRC cis rs2836974 0.897 rs4817996 chr21:40525759 G/C cg06238570 chr21:40685208 BRWD1 0.71 10.1 0.49 4.5e-21 Cognitive function; CRC cis rs1552244 1.000 rs12152512 chr3:10143770 C/T cg13047869 chr3:10149882 C3orf24 0.52 7.37 0.38 1.35e-12 Alzheimer's disease; CRC cis rs853679 0.882 rs9380064 chr6:28143118 A/G cg03623178 chr6:28175578 NA 0.79 6.36 0.33 6.62e-10 Depression; CRC cis rs524281 0.817 rs7115081 chr11:65853541 A/G cg14036092 chr11:66035641 RAB1B -0.47 -5.75 -0.3 2.01e-8 Electroencephalogram traits; CRC cis rs2153535 0.562 rs10458225 chr6:8386004 G/A cg21535247 chr6:8435926 SLC35B3 -0.41 -5.95 -0.31 6.76e-9 Motion sickness; CRC cis rs3785574 0.924 rs2727292 chr17:61893747 A/G cg11494091 chr17:61959527 GH2 0.37 5.66 0.3 3.34e-8 Height; CRC cis rs28830936 1.000 rs17676742 chr15:41903048 A/G cg17847044 chr15:42102381 MAPKBP1 -0.29 -6.08 -0.32 3.42e-9 Diastolic blood pressure; CRC cis rs6582630 0.519 rs12372510 chr12:38293074 T/C cg26384229 chr12:38710491 ALG10B 0.69 9.82 0.48 3.87e-20 Drug-induced liver injury (flucloxacillin); CRC cis rs13315871 1.000 rs9844128 chr3:58391127 C/T cg20936604 chr3:58311152 NA -0.73 -7.0 -0.36 1.46e-11 Cholesterol, total; CRC trans rs453301 0.571 rs2929452 chr8:9084465 G/A cg16141378 chr3:129829833 LOC729375 0.4 6.09 0.32 3.07e-9 Joint mobility (Beighton score); CRC cis rs12928939 0.911 rs12919271 chr16:71792696 C/A cg03805757 chr16:71968109 PKD1L3 -0.47 -5.97 -0.31 6.25e-9 Post bronchodilator FEV1; CRC cis rs5167 0.504 rs7248162 chr19:45454686 T/C cg13119609 chr19:45449297 APOC2 0.31 5.81 0.3 1.5e-8 Blood protein levels; CRC cis rs1552244 0.882 rs112621205 chr3:10017916 G/A cg18598329 chr3:10140678 FANCD2;C3orf24 -0.81 -10.69 -0.51 4.18e-23 Alzheimer's disease; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg16400469 chr20:62339231 ARFRP1;ZGPAT 0.46 6.43 0.33 4.41e-10 Anxiety disorder; CRC cis rs9943753 0.525 rs6606708 chr12:109833146 T/C cg19025524 chr12:109796872 NA -0.53 -8.05 -0.41 1.56e-14 HDL cholesterol; CRC cis rs11628318 0.591 rs8010679 chr14:103155637 T/G cg12046867 chr14:103022105 NA 0.42 6.16 0.32 2.16e-9 Platelet count; CRC cis rs10751667 0.580 rs10751664 chr11:927077 T/G ch.11.42038R chr11:967971 AP2A2 0.6 10.22 0.49 1.74e-21 Alzheimer's disease (late onset); CRC cis rs11098499 0.909 rs10020034 chr4:120294331 A/G cg09307838 chr4:120376055 NA 0.71 10.91 0.52 7.37e-24 Corneal astigmatism; CRC cis rs9393777 0.513 rs13190754 chr6:26587406 G/A cg12292205 chr6:26970375 C6orf41 -0.61 -6.9 -0.36 2.75e-11 Intelligence (multi-trait analysis); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg23812393 chr1:92949959 GFI1 0.39 6.29 0.33 1e-9 Intelligence (multi-trait analysis); CRC cis rs877282 0.838 rs11253408 chr10:796374 T/C cg17470449 chr10:769945 NA 0.68 9.03 0.45 1.48e-17 Uric acid levels; CRC cis rs7945705 0.967 rs10769970 chr11:8917937 A/G cg12365402 chr11:9010492 NRIP3 0.49 7.95 0.4 3.07e-14 Hemoglobin concentration; CRC cis rs6534441 0.727 rs77899971 chr4:125419177 C/G cg21609808 chr4:125404261 NA 0.45 6.38 0.33 6.04e-10 Major depressive disorder; CRC cis rs6662572 0.737 rs56140667 chr1:46411715 T/C cg08644498 chr1:46502608 NA 0.43 6.76 0.35 6.27e-11 Blood protein levels; CRC cis rs11711311 0.911 rs28577577 chr3:113447276 A/G cg15478005 chr3:113465772 ATP6V1A;NAA50 0.45 6.15 0.32 2.19e-9 IgG glycosylation; CRC cis rs6951245 1.000 rs111899361 chr7:1112348 C/T cg04025307 chr7:1156635 C7orf50 0.67 7.14 0.37 5.93e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs881375 0.967 rs7046108 chr9:123660339 A/G cg00246817 chr9:123691163 NA 0.49 6.23 0.32 1.45e-9 Rheumatoid arthritis; CRC cis rs4434138 0.683 rs13063160 chr3:52602274 T/C cg08222913 chr3:52553049 STAB1 -0.34 -6.42 -0.33 4.81e-10 Intelligence (multi-trait analysis); CRC cis rs9291683 0.530 rs4697698 chr4:9942577 C/T cg00071950 chr4:10020882 SLC2A9 0.64 11.85 0.55 3.29e-27 Bone mineral density; CRC trans rs2303319 0.504 rs62189055 chr2:162625749 C/A cg18122310 chr12:50236657 BCDIN3D -0.73 -6.29 -0.33 1.02e-9 Cognitive function; CRC cis rs1862618 0.853 rs252915 chr5:56121754 C/T cg18230493 chr5:56204884 C5orf35 0.66 8.76 0.43 1.08e-16 Initial pursuit acceleration; CRC cis rs10504229 0.953 rs72650891 chr8:58179697 T/G cg22535103 chr8:58192502 C8orf71 -0.82 -12.27 -0.56 9.63e-29 Developmental language disorder (linguistic errors); CRC cis rs12594515 1.000 rs12595137 chr15:45986105 G/T cg01629716 chr15:45996671 NA 0.4 8.25 0.41 3.97e-15 Waist circumference;Weight; CRC cis rs2243480 1.000 rs6460260 chr7:65215455 T/C cg25985355 chr7:65971099 NA 0.5 5.84 0.31 1.28e-8 Diabetic kidney disease; CRC cis rs11123170 0.543 rs4849180 chr2:113985186 C/G cg21482265 chr2:113992762 PAX8;LOC440839;LOC654433 0.51 6.05 0.32 3.84e-9 Renal function-related traits (BUN); CRC cis rs17818399 0.890 rs34544165 chr2:46836906 A/G cg26688816 chr2:46740690 ATP6V1E2 -0.41 -5.62 -0.3 3.99e-8 Height; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg09936566 chr1:163292020 NUF2 0.45 6.29 0.33 1.01e-9 Response to antipsychotic treatment; CRC cis rs270601 0.770 rs932019 chr5:131599370 T/C cg18301423 chr5:131593218 PDLIM4 0.45 8.33 0.42 2.22e-15 Acylcarnitine levels; CRC cis rs2295359 0.892 rs10889657 chr1:67615487 A/G cg03340356 chr1:67600835 NA 0.29 6.53 0.34 2.56e-10 Psoriasis; CRC cis rs10170846 0.530 rs56353541 chr2:223421187 G/C cg25565276 chr2:223520875 FARSB 0.55 7.51 0.38 5.44e-13 Schizophrenia (inflammation and infection response interaction); CRC cis rs9733 0.596 rs6686525 chr1:150635811 C/T cg18016565 chr1:150552671 MCL1 0.47 6.81 0.35 4.55e-11 Tonsillectomy; CRC trans rs7267979 0.966 rs2482918 chr20:25412135 C/T cg17903999 chr18:56338584 MALT1 0.42 6.9 0.36 2.74e-11 Liver enzyme levels (alkaline phosphatase); CRC cis rs7927771 0.524 rs7123952 chr11:47852057 T/C cg20307385 chr11:47447363 PSMC3 0.46 6.66 0.34 1.18e-10 Subjective well-being; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg15598511 chr20:1447287 NSFL1C 0.43 6.0 0.31 5.14e-9 Anxiety disorder; CRC cis rs12403795 0.527 rs17648533 chr1:150316576 A/G cg17724175 chr1:150552817 MCL1 0.63 5.96 0.31 6.5e-9 Illicit drug use; CRC cis rs9325144 0.560 rs13377717 chr12:38639474 T/A cg26384229 chr12:38710491 ALG10B -0.48 -7.16 -0.37 5.17e-12 Morning vs. evening chronotype; CRC trans rs11039571 0.588 rs10734564 chr11:48160429 A/G cg15704280 chr7:45808275 SEPT13 -0.73 -8.02 -0.4 1.91e-14 D-dimer levels; CRC cis rs17376456 0.877 rs17316137 chr5:93456577 C/T cg09848695 chr5:92956644 FAM172A;MIR2277 0.67 6.38 0.33 6.13e-10 Diabetic retinopathy; CRC cis rs1552244 0.572 rs66514627 chr3:10166632 A/C cg13047869 chr3:10149882 C3orf24 0.54 6.49 0.34 3.1e-10 Alzheimer's disease; CRC cis rs992157 1.000 rs13429408 chr2:219142860 C/A cg04731861 chr2:219085781 ARPC2 -0.27 -5.81 -0.31 1.47e-8 Colorectal cancer; CRC cis rs1008375 0.932 rs6857678 chr4:17696964 A/T cg16339924 chr4:17578868 LAP3 0.49 6.63 0.34 1.39e-10 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs1801251 1.000 rs283468 chr2:233658309 C/T cg25237894 chr2:233734115 C2orf82 0.56 9.04 0.45 1.33e-17 Coronary artery disease; CRC cis rs4663969 0.733 rs6741669 chr2:234653192 A/G cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.46 -7.22 -0.37 3.72e-12 Total bilirubin levels in HIV-1 infection; CRC cis rs748404 0.578 rs512628 chr15:43618734 A/G cg02155558 chr15:43621948 ADAL;LCMT2 0.51 7.31 0.37 2.08e-12 Lung cancer; CRC cis rs11098499 0.908 rs71614449 chr4:120387055 C/T cg09307838 chr4:120376055 NA 0.71 10.92 0.52 6.75e-24 Corneal astigmatism; CRC cis rs10191773 0.535 rs11123133 chr2:112965023 G/A cg23609528 chr2:113191194 RGPD5;RGPD8 0.63 5.62 0.3 4.01e-8 Yeast infection; CRC cis rs9303280 0.806 rs9303279 chr17:38073968 G/C cg17344932 chr17:38183730 MED24;SNORD124 -0.39 -6.17 -0.32 1.96e-9 Self-reported allergy; CRC cis rs9682041 0.627 rs34392658 chr3:170091584 C/T cg11886554 chr3:170076028 SKIL 0.63 7.83 0.4 6.75e-14 Glomerular filtration rate in non diabetics (creatinine);Glomerular filtration rate (creatinine); CRC cis rs728616 0.717 rs116884206 chr10:81990546 A/G cg05935833 chr10:81318306 SFTPA2 -0.78 -7.86 -0.4 5.42e-14 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs6952808 0.575 rs6950330 chr7:1953606 T/C cg22963979 chr7:1858916 MAD1L1 -0.43 -6.83 -0.35 4.07e-11 Bipolar disorder and schizophrenia; CRC cis rs11190604 0.943 rs11190588 chr10:102273565 C/T cg16342193 chr10:102329863 NA -0.39 -6.24 -0.33 1.32e-9 Palmitoleic acid (16:1n-7) levels; CRC cis rs1865760 0.964 rs9379802 chr6:25933898 T/A cg16482183 chr6:26056742 HIST1H1C 0.49 6.93 0.36 2.18e-11 Height; CRC cis rs853679 0.550 rs1233701 chr6:28168726 C/G cg23161317 chr6:28129485 ZNF389 -0.44 -5.82 -0.31 1.38e-8 Depression; CRC cis rs9648716 0.766 rs801158 chr7:140780955 A/G cg10747023 chr7:140774559 NA -0.46 -6.09 -0.32 3.1e-9 Type 2 diabetes; CRC cis rs765787 0.530 rs7167389 chr15:45535683 A/G cg24006582 chr15:45444508 DUOX1 -0.58 -8.91 -0.44 3.55e-17 Uric acid levels; CRC cis rs1153858 1.000 rs10519022 chr15:45663684 C/T cg14582100 chr15:45693742 SPATA5L1 -0.29 -6.06 -0.32 3.63e-9 Homoarginine levels; CRC cis rs11098499 0.575 rs907204 chr4:120238654 G/A cg09307838 chr4:120376055 NA 0.62 9.75 0.47 6.92e-20 Corneal astigmatism; CRC cis rs5769765 0.862 rs138856 chr22:50199378 G/T cg08270630 chr22:50330655 NA -0.41 -5.98 -0.31 5.85e-9 Schizophrenia; CRC trans rs208520 1.000 rs9453663 chr6:66976077 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.84 10.38 0.5 4.9e-22 Exhaled nitric oxide output; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg11297934 chr3:12705869 RAF1 -0.42 -6.33 -0.33 8.01e-10 Myopia (pathological); CRC cis rs372883 0.648 rs2832297 chr21:30742996 A/C cg24692254 chr21:30365293 RNF160 0.62 9.36 0.46 1.28e-18 Pancreatic cancer; CRC cis rs9660180 0.934 rs34849348 chr1:1762757 C/T cg23982607 chr1:1823379 GNB1 -0.88 -15.57 -0.65 2.54e-41 Body mass index; CRC cis rs6831352 0.918 rs29001199 chr4:100053891 A/G cg12011299 chr4:100065546 ADH4 -0.49 -9.17 -0.45 5.32e-18 Alcohol dependence; CRC cis rs10208712 0.505 rs4553834 chr2:4048065 A/G cg00217080 chr2:4050767 NA 0.26 6.48 0.34 3.44e-10 Restless legs syndrome; CRC cis rs1475911 1.000 rs55645900 chr21:43515728 G/T cg14562523 chr21:43528734 C21orf128;UMODL1 -0.5 -6.71 -0.35 8.75e-11 IgG glycosylation; CRC cis rs6502050 0.835 rs9898697 chr17:80100498 A/G cg13198984 chr17:80129470 CCDC57 0.43 7.61 0.39 2.95e-13 Life satisfaction; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg06913287 chr2:18742029 RDH14 0.4 6.27 0.33 1.11e-9 Liver disease severity in Alagille syndrome; CRC cis rs769267 0.930 rs4808965 chr19:19631655 A/G cg03709012 chr19:19516395 GATAD2A 0.72 11.18 0.52 7.91e-25 Tonsillectomy; CRC cis rs4713118 0.869 rs9393851 chr6:27699581 A/T cg15786705 chr6:28176104 NA 0.54 7.62 0.39 2.72e-13 Parkinson's disease; CRC cis rs514406 0.607 rs6696940 chr1:53203427 C/T cg27535305 chr1:53392650 SCP2 0.36 6.47 0.34 3.52e-10 Monocyte count; CRC cis rs7666738 0.830 rs35951881 chr4:98999474 A/C cg05340658 chr4:99064831 C4orf37 0.61 9.54 0.47 3.44e-19 Colonoscopy-negative controls vs population controls; CRC cis rs7131987 0.903 rs2216853 chr12:29413248 C/G cg09582351 chr12:29534625 ERGIC2 -0.29 -6.01 -0.31 4.81e-9 QT interval; CRC cis rs8180040 0.874 rs11130123 chr3:47285912 A/G cg02527881 chr3:46936655 PTH1R -0.4 -7.52 -0.38 5.24e-13 Colorectal cancer; CRC cis rs6960043 0.818 rs10267273 chr7:15053589 A/G cg19272540 chr7:15055459 NA -0.22 -5.92 -0.31 7.94e-9 Type 2 diabetes; CRC cis rs4728302 0.869 rs10253633 chr7:133590869 A/G cg03336402 chr7:133662267 EXOC4 -0.44 -6.41 -0.33 4.91e-10 Intelligence;Intelligence (multi-trait analysis); CRC cis rs7804356 1.000 rs3801816 chr7:26881177 G/A cg03456212 chr7:26904342 SKAP2 -0.49 -5.62 -0.3 4.1e-8 Type 1 diabetes; CRC cis rs4750440 0.637 rs2447010 chr10:14032115 T/C cg00551146 chr10:14014579 FRMD4A 0.45 8.06 0.41 1.4e-14 Adiponectin levels; CRC cis rs35306767 0.761 rs12770173 chr10:1027108 A/C cg26597838 chr10:835615 NA 0.95 10.61 0.5 8.04e-23 Eosinophil percentage of granulocytes; CRC cis rs28386778 0.669 rs12603821 chr17:62006432 G/A cg06873352 chr17:61820015 STRADA -0.54 -8.98 -0.44 2.2e-17 Prudent dietary pattern; CRC cis rs2204008 0.744 rs8189486 chr12:38244968 C/T cg26384229 chr12:38710491 ALG10B 0.69 9.22 0.45 3.69e-18 Bladder cancer; CRC cis rs2404602 0.583 rs2469542 chr15:76557476 A/G cg22467129 chr15:76604101 ETFA 0.48 8.51 0.42 6.09e-16 Blood metabolite levels; CRC cis rs12451471 0.559 rs12452263 chr17:78079310 T/C cg12326244 chr17:78078995 GAA -0.38 -5.77 -0.3 1.87e-8 Plateletcrit;Mean corpuscular hemoglobin concentration; CRC trans rs2303319 0.504 rs62189051 chr2:162622318 G/A cg09481857 chr22:21368659 P2RX6;MGC16703 -0.64 -6.28 -0.33 1.08e-9 Cognitive function; CRC cis rs12200560 0.505 rs9400167 chr6:97077192 G/T cg06623918 chr6:96969491 KIAA0776 0.52 7.77 0.39 1.02e-13 Coronary heart disease; CRC cis rs9463078 0.715 rs9357459 chr6:44782562 C/T cg25276700 chr6:44698697 NA -0.27 -6.4 -0.33 5.22e-10 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; CRC cis rs2398893 0.924 rs1539282 chr9:96827424 T/C cg14459158 chr9:96720562 NA 0.43 7.18 0.37 4.71e-12 Waist-hip ratio;Waist-to-hip ratio adjusted for body mass index; CRC cis rs11098499 0.908 rs12504149 chr4:120318577 G/A cg09307838 chr4:120376055 NA 0.7 10.81 0.51 1.71e-23 Corneal astigmatism; CRC cis rs875971 0.862 rs778734 chr7:65814849 C/G cg18876405 chr7:65276391 NA 0.52 8.55 0.43 4.66e-16 Aortic root size; CRC cis rs7178572 0.568 rs4886850 chr15:77404160 G/C cg22256960 chr15:77711686 NA -0.63 -8.81 -0.44 7.29e-17 Type 2 diabetes; CRC cis rs992157 0.798 rs10193383 chr2:219157692 C/T cg04731861 chr2:219085781 ARPC2 -0.3 -6.22 -0.32 1.47e-9 Colorectal cancer; CRC cis rs2836974 0.568 rs371625 chr21:40535271 A/G cg11890956 chr21:40555474 PSMG1 -0.92 -16.78 -0.68 4.34e-46 Cognitive function; CRC cis rs9443645 0.869 rs9448591 chr6:79606490 C/T cg09184832 chr6:79620586 NA -0.52 -9.73 -0.47 8.04e-20 Intelligence (multi-trait analysis); CRC cis rs9900062 1.000 rs2521879 chr17:62742678 A/G cg02097616 chr17:62675921 NA 0.47 5.74 0.3 2.18e-8 QT interval; CRC cis rs12936587 0.777 rs12951347 chr17:17534513 C/G cg09796270 chr17:17721594 SREBF1 -0.42 -5.97 -0.31 6.09e-9 Hip circumference;Coronary artery disease or large artery stroke;Coronary heart disease;Coronary artery disease; CRC cis rs4481887 0.962 rs4244177 chr1:248468279 C/T cg13385794 chr1:248469461 NA 0.38 6.8 0.35 5.07e-11 Common traits (Other); CRC cis rs10911251 0.546 rs1051473 chr1:183114146 T/C ch.1.3577855R chr1:183094577 LAMC1 0.8 13.6 0.6 9.52e-34 Colorectal cancer; CRC cis rs2153535 0.580 rs2327051 chr6:8441150 A/G cg21535247 chr6:8435926 SLC35B3 -0.48 -7.15 -0.37 5.52e-12 Motion sickness; CRC cis rs7927592 0.513 rs608343 chr11:68196830 T/C cg16797656 chr11:68205561 LRP5 0.57 10.33 0.49 7.36e-22 Total body bone mineral density; CRC cis rs7605827 0.930 rs2111458 chr2:15598039 T/A cg19274914 chr2:15703543 NA 0.4 5.97 0.31 6.3e-9 Educational attainment (years of education); CRC trans rs1997103 1.000 rs4628219 chr7:55410449 A/G cg20935933 chr6:143382018 AIG1 0.51 6.65 0.34 1.25e-10 QRS interval (sulfonylurea treatment interaction); CRC cis rs4478858 0.660 rs10798844 chr1:31819128 A/G cg00250761 chr1:31883323 NA -0.44 -8.12 -0.41 9.21e-15 Alcohol dependence; CRC trans rs4332037 0.802 rs73048106 chr7:1929019 G/T cg11693508 chr17:37793320 STARD3 0.71 8.51 0.42 6.03e-16 Bipolar disorder; CRC cis rs1528435 1.000 rs6727573 chr2:181522783 T/C cg23363182 chr2:181467187 NA -0.35 -5.66 -0.3 3.22e-8 Body mass index; CRC cis rs7618915 0.571 rs1961958 chr3:52585990 A/G cg15147215 chr3:52552868 STAB1 -0.63 -10.61 -0.5 8.25e-23 Bipolar disorder; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg17094688 chr17:17380209 MED9 0.39 7.03 0.36 1.23e-11 Liver disease severity in Alagille syndrome; CRC cis rs10504229 0.679 rs11781858 chr8:58038406 C/T cg11062466 chr8:58055876 NA 0.52 6.31 0.33 8.8e-10 Developmental language disorder (linguistic errors); CRC cis rs7249142 0.549 rs2283623 chr19:19283027 G/C cg26504305 chr19:19281019 LOC729991-MEF2B;MEF2B -0.4 -7.99 -0.4 2.38e-14 IgG glycosylation; CRC cis rs875971 0.638 rs7793569 chr7:66116633 T/G cg18876405 chr7:65276391 NA -0.61 -10.75 -0.51 2.66e-23 Aortic root size; CRC cis rs3858526 0.584 rs10769271 chr11:5860572 T/C cg13902645 chr11:5959945 NA -0.66 -9.18 -0.45 4.99e-18 DNA methylation (variation); CRC cis rs9311474 0.713 rs352168 chr3:52237970 C/T cg15147215 chr3:52552868 STAB1 -0.51 -8.24 -0.41 4.04e-15 Electroencephalogram traits; CRC cis rs501120 0.925 rs1746049 chr10:44776310 C/T cg09554077 chr10:44749378 NA 0.74 11.02 0.52 2.91e-24 Coronary artery disease;Coronary heart disease; CRC cis rs10504229 0.639 rs2318146 chr8:58114873 T/G cg24829409 chr8:58192753 C8orf71 -0.54 -7.88 -0.4 4.9e-14 Developmental language disorder (linguistic errors); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg04763192 chr1:111889241 C1orf88 0.4 6.31 0.33 9e-10 Intelligence (multi-trait analysis); CRC cis rs67478160 0.655 rs4900598 chr14:104281541 T/C cg01849466 chr14:104193079 ZFYVE21 -0.46 -8.15 -0.41 7.95e-15 Schizophrenia; CRC trans rs10982213 0.830 rs2274163 chr9:117188714 C/T cg15560884 chr1:710097 NA -0.38 -6.8 -0.35 4.91e-11 Interleukin-6 levels; CRC trans rs6598955 0.617 rs11247895 chr1:26599542 G/A cg07461501 chr17:79650226 HGS;ARL16 -0.52 -6.19 -0.32 1.77e-9 Obesity-related traits; CRC cis rs4523957 0.786 rs216213 chr17:2134225 G/A cg16513277 chr17:2031491 SMG6 0.52 8.69 0.43 1.7e-16 Autism spectrum disorder or schizophrenia;Schizophrenia; CRC cis rs1065656 0.619 rs2492883 chr16:1902105 C/T cg14074117 chr16:1909714 C16orf73 0.36 6.2 0.32 1.65e-9 Insulin-like growth factors; CRC cis rs2075671 0.903 rs62482252 chr7:100274063 C/A cg20848291 chr7:100343083 ZAN -0.71 -10.15 -0.49 3.02e-21 Other erythrocyte phenotypes; CRC cis rs763014 0.593 rs28455838 chr16:681966 T/C cg00908189 chr16:619842 PIGQ 0.65 10.53 0.5 1.5e-22 Height; CRC cis rs5750830 0.595 rs4821892 chr22:39795683 G/C cg25956985 chr22:39795188 MAP3K7IP1 -0.47 -6.61 -0.34 1.51e-10 Intelligence (multi-trait analysis); CRC cis rs8177253 0.965 rs4854760 chr3:133498741 C/T cg01448562 chr3:133502909 NA 0.52 8.96 0.44 2.51e-17 Iron status biomarkers; CRC cis rs7917772 0.503 rs11191328 chr10:104305185 C/T cg04362960 chr10:104952993 NT5C2 -0.41 -5.78 -0.3 1.77e-8 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC cis rs9381040 0.655 rs9381029 chr6:41026453 G/C cg09580153 chr6:41068724 NFYA;LOC221442 -0.42 -6.13 -0.32 2.52e-9 Alzheimer's disease (late onset); CRC cis rs2013441 1.000 rs8079701 chr17:20216565 G/A cg13482628 chr17:19912719 NA -0.41 -6.38 -0.33 5.99e-10 Obesity-related traits; CRC cis rs34779708 0.966 rs12775759 chr10:35400183 G/T cg03585969 chr10:35415529 CREM 0.66 8.73 0.43 1.33e-16 Inflammatory bowel disease;Crohn's disease; CRC cis rs2228479 0.702 rs3819574 chr16:89826630 G/A cg06656553 chr16:89960601 TCF25 -0.7 -5.76 -0.3 1.93e-8 Skin colour saturation; CRC cis rs35110281 0.720 rs162372 chr21:44928863 C/T cg04455712 chr21:45112962 RRP1B -0.42 -8.02 -0.4 1.89e-14 Mean corpuscular volume; CRC cis rs1865760 0.713 rs9461229 chr6:25992279 G/T cg17691542 chr6:26056736 HIST1H1C 0.56 8.79 0.44 8.4e-17 Height; CRC cis rs7193541 0.694 rs3896277 chr16:74480694 A/T cg01733217 chr16:74700730 RFWD3 0.78 13.78 0.6 2.06e-34 Multiple myeloma; CRC cis rs6867913 0.951 rs4912799 chr5:141453720 G/C cg08523384 chr5:141488047 NDFIP1 0.45 6.47 0.34 3.55e-10 Asthma; CRC cis rs2976388 0.578 rs13254358 chr8:143823876 G/A cg04969067 chr8:143858791 LYNX1 -0.41 -6.18 -0.32 1.9e-9 Urinary tract infection frequency; CRC cis rs1799949 1.000 rs8176133 chr17:41257458 A/C cg25072359 chr17:41440525 NA 0.44 6.5 0.34 2.96e-10 Menopause (age at onset); CRC cis rs7647973 0.593 rs59684465 chr3:49874246 C/T cg03060546 chr3:49711283 APEH -0.67 -8.03 -0.4 1.7e-14 Menarche (age at onset); CRC trans rs1814175 0.817 rs7947286 chr11:49874657 C/T cg03929089 chr4:120376271 NA -0.97 -19.07 -0.72 3.93e-55 Height; CRC cis rs1552244 0.832 rs61056817 chr3:10027641 C/T cg08888203 chr3:10149979 C3orf24 0.55 6.75 0.35 6.79e-11 Alzheimer's disease; CRC cis rs61996546 0.622 rs12900771 chr15:26835235 G/A cg15066197 chr15:26874202 GABRB3 -0.41 -6.16 -0.32 2.07e-9 Response to methotrexate in juvenile idiopathic arthritis; CRC cis rs1322639 0.571 rs13204417 chr6:169575355 G/A cg04662567 chr6:169592167 NA 0.32 5.91 0.31 8.45e-9 Pulse pressure; CRC cis rs875971 0.508 rs10950045 chr7:66066373 T/C cg11764359 chr7:65958608 NA -0.5 -7.63 -0.39 2.51e-13 Aortic root size; CRC cis rs10751667 0.677 rs11246386 chr11:1044938 C/T ch.11.42038R chr11:967971 AP2A2 -0.51 -6.72 -0.35 7.96e-11 Alzheimer's disease (late onset); CRC cis rs1448094 0.512 rs10779216 chr12:86240315 A/G cg18827107 chr12:86230957 RASSF9 0.45 7.41 0.38 1.06e-12 Major depressive disorder; CRC cis rs5769765 0.908 rs4074304 chr22:50309446 G/A cg22709217 chr22:50311962 ALG12;CRELD2 -1.13 -18.9 -0.72 1.86e-54 Schizophrenia; CRC cis rs60733400 0.500 rs72644697 chr1:2533605 G/A cg20673091 chr1:2541236 MMEL1 0.37 5.91 0.31 8.76e-9 Multiple sclerosis; CRC cis rs13064411 0.735 rs7631138 chr3:113231925 A/T cg18753928 chr3:113234510 CCDC52 -0.69 -10.64 -0.51 6.41e-23 Response to simvastatin treatment (PCSK9 protein level change); CRC cis rs11785400 0.793 rs4430070 chr8:143729184 G/C cg24634471 chr8:143751801 JRK 0.52 7.14 0.37 6.06e-12 Schizophrenia; CRC cis rs6502050 0.835 rs9900128 chr17:80087920 A/T cg25804541 chr17:80189381 SLC16A3 -0.3 -5.84 -0.31 1.24e-8 Life satisfaction; CRC cis rs9486719 0.857 rs9285393 chr6:97020917 C/A cg06623918 chr6:96969491 KIAA0776 -0.75 -9.75 -0.47 6.74e-20 Migraine;Coronary artery disease; CRC cis rs6988985 0.626 rs6392 chr8:143956925 T/C cg10324643 chr8:143916377 GML 0.4 6.62 0.34 1.46e-10 Plasma androstenedione levels in resected early stage-receptor positive breast cancer; CRC cis rs6502050 0.799 rs8066370 chr17:80102105 T/C cg02741985 chr17:80059408 CCDC57 0.43 7.15 0.37 5.66e-12 Life satisfaction; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg03792199 chr7:27702785 HIBADH 0.44 6.25 0.33 1.31e-9 Response to antipsychotic treatment; CRC cis rs1355223 0.545 rs7111695 chr11:34874906 T/G cg11058730 chr11:34937778 PDHX;APIP -0.43 -6.07 -0.32 3.51e-9 Systemic lupus erythematosus and Systemic sclerosis; CRC cis rs9768139 0.634 rs56389048 chr7:158121368 T/A cg25566285 chr7:158114605 PTPRN2 0.47 7.37 0.38 1.39e-12 Calcium levels; CRC cis rs7208859 0.623 rs8082537 chr17:29015932 T/C cg13385521 chr17:29058706 SUZ12P 0.6 7.26 0.37 2.73e-12 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg11904759 chr17:80656664 RAB40B 0.47 6.92 0.36 2.36e-11 Response to antipsychotic treatment; CRC cis rs9427116 0.740 rs11264230 chr1:154608418 G/T cg17218026 chr1:154582156 ADAR 0.63 10.22 0.49 1.74e-21 Blood protein levels; CRC cis rs1005277 0.528 rs2057228 chr10:38515766 T/C cg00409905 chr10:38381863 ZNF37A -0.62 -10.29 -0.49 1.04e-21 Extrinsic epigenetic age acceleration; CRC cis rs9467773 1.000 rs6925895 chr6:26572165 G/T cg09904177 chr6:26538194 HMGN4 0.86 14.82 0.63 2.06e-38 Intelligence (multi-trait analysis); CRC cis rs11098499 0.955 rs13129661 chr4:120152909 C/G cg09307838 chr4:120376055 NA 0.62 9.42 0.46 8.45e-19 Corneal astigmatism; CRC cis rs2842992 0.789 rs2295901 chr6:160201295 C/A cg19482086 chr6:160211437 TCP1;MRPL18 0.73 9.65 0.47 1.4e-19 Age-related macular degeneration (geographic atrophy); CRC cis rs7089973 0.872 rs41284358 chr10:116622339 A/G cg03647239 chr10:116582469 FAM160B1 0.41 5.79 0.3 1.67e-8 Bipolar disorder or attention deficit hyperactivity disorder; CRC cis rs1008375 1.000 rs28545485 chr4:17645376 C/T cg02297831 chr4:17616191 MED28 0.44 5.83 0.31 1.29e-8 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs9303401 0.614 rs35057477 chr17:57097064 G/A cg02118635 chr17:56770003 RAD51C;TEX14 0.77 9.44 0.46 7.12e-19 Cognitive test performance; CRC cis rs10504229 0.683 rs17194792 chr8:58107195 A/C cg24829409 chr8:58192753 C8orf71 -0.69 -8.31 -0.42 2.49e-15 Developmental language disorder (linguistic errors); CRC cis rs8072100 0.713 rs4968228 chr17:45497548 T/C cg25173405 chr17:45401733 C17orf57 -0.42 -6.22 -0.32 1.5e-9 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC trans rs2797160 0.651 rs6569437 chr6:126034540 T/G cg05039488 chr6:79577232 IRAK1BP1 0.56 8.7 0.43 1.6e-16 Endometrial cancer; CRC cis rs9925964 0.933 rs2359612 chr16:31103796 A/G cg02466173 chr16:30829666 NA -0.42 -5.75 -0.3 2.07e-8 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs11098699 0.821 rs13120866 chr4:124199293 A/G cg09941581 chr4:124220074 SPATA5 0.41 5.95 0.31 6.87e-9 Mosquito bite size; CRC cis rs561341 0.830 rs7218801 chr17:30217778 A/G cg00745463 chr17:30367425 LRRC37B 0.69 8.13 0.41 9.09e-15 Hip circumference adjusted for BMI; CRC cis rs2153535 0.580 rs6938071 chr6:8464845 A/T cg07606381 chr6:8435919 SLC35B3 0.67 10.82 0.51 1.51e-23 Motion sickness; CRC cis rs3820068 0.603 rs7536654 chr1:15989141 C/G cg27534772 chr1:16042836 PLEKHM2 0.52 10.5 0.5 2e-22 Systolic blood pressure; CRC cis rs875971 0.965 rs7794930 chr7:65778546 A/C cg00343986 chr7:65444356 GUSB -0.44 -6.4 -0.33 5.29e-10 Aortic root size; CRC cis rs7831492 0.564 rs11787479 chr8:41613496 A/G cg17182837 chr8:41585554 ANK1 -0.62 -10.51 -0.5 1.88e-22 Colorectal cancer; CRC cis rs4478858 0.735 rs6425737 chr1:31790288 T/C cg00250761 chr1:31883323 NA -0.44 -8.36 -0.42 1.75e-15 Alcohol dependence; CRC cis rs780096 0.526 rs1647276 chr2:27688601 C/T cg27432699 chr2:27873401 GPN1 -0.52 -7.96 -0.4 2.91e-14 Total body bone mineral density; CRC cis rs753778 0.570 rs4961335 chr8:142209142 A/G cg23750338 chr8:142222470 SLC45A4 0.36 6.05 0.32 4.03e-9 Reticulocyte fraction of red cells;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; CRC cis rs7215564 0.908 rs35918698 chr17:78683533 G/A cg09596252 chr17:78655493 RPTOR 0.56 6.15 0.32 2.26e-9 Myopia (pathological); CRC trans rs6788895 0.661 rs1533711 chr3:150469996 C/T cg03041920 chr13:100310311 CLYBL 0.6 6.12 0.32 2.63e-9 Breast cancer; CRC cis rs644799 0.965 rs607039 chr11:95547086 G/A cg25622487 chr11:95524042 FAM76B;CEP57 0.76 11.87 0.55 2.62e-27 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs875971 0.862 rs1981799 chr7:65955559 T/C cg12463550 chr7:65579703 CRCP 0.47 6.71 0.35 8.61e-11 Aortic root size; CRC cis rs7208859 0.673 rs9891179 chr17:29208160 G/T cg13385521 chr17:29058706 SUZ12P 0.69 8.01 0.4 2.02e-14 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC trans rs2243480 1.000 rs186378 chr7:65582058 A/C cg10756647 chr7:56101905 PSPH 0.73 7.68 0.39 1.79e-13 Diabetic kidney disease; CRC cis rs11628318 0.660 rs4906242 chr14:103085063 G/A cg23461800 chr14:103021989 NA -0.7 -8.05 -0.41 1.57e-14 Platelet count; CRC trans rs35110281 0.782 rs7282933 chr21:45046988 A/G cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.51 8.63 0.43 2.76e-16 Mean corpuscular volume; CRC cis rs1153858 1.000 rs4774578 chr15:45646051 G/A cg14582100 chr15:45693742 SPATA5L1 0.28 5.91 0.31 8.44e-9 Homoarginine levels; CRC cis rs4604732 0.578 rs12038656 chr1:247623816 A/G cg02104434 chr1:247694406 LOC148824;OR2C3 0.62 9.32 0.46 1.75e-18 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CRC cis rs1153858 1.000 rs66714503 chr15:45648038 G/C cg14582100 chr15:45693742 SPATA5L1 0.28 5.91 0.31 8.44e-9 Homoarginine levels; CRC cis rs35520189 0.591 rs6705432 chr2:113701824 C/T cg12858261 chr2:113808755 IL1F8 0.49 6.87 0.35 3.29e-11 Obstructive sleep apnea trait (apnea hypopnea index); CRC cis rs12908161 1.000 rs35316992 chr15:85248133 A/G cg17507749 chr15:85114479 UBE2QP1 0.63 8.87 0.44 4.91e-17 Schizophrenia; CRC cis rs1580019 0.587 rs6951955 chr7:32548761 A/T cg14728415 chr7:32535168 LSM5;AVL9 0.45 6.48 0.34 3.28e-10 Cognitive ability; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg21783428 chr6:3118692 BPHL 0.41 6.64 0.34 1.34e-10 Liver disease severity in Alagille syndrome; CRC cis rs7512552 0.724 rs7002 chr1:150445819 A/G cg15654264 chr1:150340011 RPRD2 0.59 8.11 0.41 9.88e-15 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); CRC cis rs9649465 0.902 rs10253850 chr7:123273095 T/C cg03229431 chr7:123269106 ASB15 -0.43 -6.59 -0.34 1.72e-10 Migraine; CRC cis rs8008758 1.000 rs12432879 chr14:101688977 A/G cg26224664 chr14:101693935 NA 0.42 6.54 0.34 2.34e-10 Body mass index (alcohol intake interaction); CRC cis rs3008870 1.000 rs2755250 chr1:67495283 A/G cg08660285 chr1:67390436 MIER1;WDR78 1.01 14.69 0.63 6.23e-38 Lymphocyte percentage of white cells; CRC cis rs834811 1.000 rs834811 chr7:135884571 A/G cg01726295 chr7:135938950 NA 0.4 6.85 0.35 3.55e-11 Post-traumatic stress disorder; CRC cis rs875971 0.964 rs6945019 chr7:65922458 C/G cg00343986 chr7:65444356 GUSB 0.43 6.26 0.33 1.21e-9 Aortic root size; CRC cis rs2067615 0.579 rs10861665 chr12:107193836 T/C cg15890332 chr12:107067104 RFX4 0.32 5.63 0.3 3.78e-8 Heart rate; CRC cis rs853679 0.574 rs1233705 chr6:28166447 C/G cg12172441 chr6:28176163 NA 0.69 9.19 0.45 4.69e-18 Depression; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg03634887 chr16:66730948 CMTM4 0.49 6.85 0.35 3.75e-11 Response to antipsychotic treatment; CRC cis rs853679 0.517 rs9380052 chr6:28064623 A/G cg15845792 chr6:28175446 NA 1.0 13.28 0.59 1.67e-32 Depression; CRC cis rs10046574 0.831 rs10227931 chr7:135084601 C/T cg27474649 chr7:135195673 CNOT4 0.69 5.71 0.3 2.58e-8 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs1003719 0.680 rs2835619 chr21:38505380 C/T cg10648535 chr21:38446584 PIGP;TTC3 -0.48 -6.65 -0.34 1.23e-10 Eye color traits; CRC cis rs2070677 1.000 rs743534 chr10:135349226 G/T cg20169779 chr10:135381914 SYCE1 0.78 11.13 0.52 1.26e-24 Gout; CRC cis rs12476592 1.000 rs12476592 chr2:63850098 G/C cg10828910 chr2:63850056 LOC388955 -0.54 -6.26 -0.33 1.19e-9 Childhood ear infection; CRC cis rs926938 0.563 rs360655 chr1:115447867 T/C cg12756093 chr1:115239321 AMPD1 0.56 8.32 0.42 2.42e-15 Autism; CRC cis rs7246760 1.000 rs67509260 chr19:9864321 C/T cg16876255 chr19:9731953 ZNF561 0.68 5.71 0.3 2.5e-8 Pursuit maintenance gain; CRC cis rs10197940 0.578 rs2432946 chr2:152306897 G/T cg19508488 chr2:152266495 RIF1 -0.46 -6.66 -0.34 1.17e-10 Lung cancer; CRC cis rs8177253 0.896 rs34252038 chr3:133490621 G/T cg16262614 chr3:133464971 TF 0.34 6.0 0.31 5.15e-9 Iron status biomarkers; CRC cis rs1448094 0.511 rs10506923 chr12:86152595 C/T cg25456477 chr12:86230367 RASSF9 -0.39 -6.54 -0.34 2.36e-10 Major depressive disorder; CRC cis rs9326248 0.861 rs7120449 chr11:117042899 T/C cg26566898 chr11:117069891 TAGLN 0.39 6.99 0.36 1.51e-11 Blood protein levels; CRC cis rs10504229 1.000 rs17217033 chr8:58180061 G/T cg05313129 chr8:58192883 C8orf71 -0.47 -6.99 -0.36 1.49e-11 Developmental language disorder (linguistic errors); CRC cis rs2439831 0.850 rs8042868 chr15:43939642 C/T cg15269541 chr15:43626905 ADAL -0.53 -5.8 -0.3 1.59e-8 Lung cancer in ever smokers; CRC cis rs55692411 0.537 rs62262118 chr3:50003586 G/A cg05623727 chr3:50126028 RBM5 0.52 6.81 0.35 4.67e-11 Intelligence (multi-trait analysis); CRC cis rs10193935 0.901 rs12619348 chr2:42625586 C/T cg27598129 chr2:42591480 NA -0.67 -7.47 -0.38 7.12e-13 Colonoscopy-negative controls vs population controls; CRC cis rs7927592 0.913 rs7116994 chr11:68254627 C/T cg01657329 chr11:68192670 LRP5 -0.46 -6.71 -0.35 8.37e-11 Total body bone mineral density; CRC cis rs7772486 0.686 rs1045820 chr6:145947080 C/T cg23711669 chr6:146136114 FBXO30 0.66 10.91 0.52 7.27e-24 Lobe attachment (rater-scored or self-reported); CRC cis rs477895 0.653 rs11602181 chr11:63896591 C/G cg05016508 chr11:63871570 FLRT1;MACROD1 0.54 7.02 0.36 1.3e-11 Mean platelet volume; CRC trans rs1728785 0.901 rs1170444 chr16:68573287 T/C cg04657470 chr2:198365150 HSPE1;HSPD1 0.56 6.67 0.35 1.1e-10 Ulcerative colitis; CRC cis rs977987 0.806 rs4888411 chr16:75443183 T/A cg03315344 chr16:75512273 CHST6 0.54 9.08 0.45 1.01e-17 Dupuytren's disease; CRC cis rs1008375 0.966 rs2872957 chr4:17651757 C/A cg16339924 chr4:17578868 LAP3 0.55 7.28 0.37 2.41e-12 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs801193 0.569 rs7800620 chr7:66223688 T/C cg12463550 chr7:65579703 CRCP 0.45 6.04 0.32 4.14e-9 Aortic root size; CRC cis rs28386778 0.687 rs59596917 chr17:61806264 T/A cg11494091 chr17:61959527 GH2 0.61 10.2 0.49 2.05e-21 Prudent dietary pattern; CRC cis rs4862750 0.957 rs1030381 chr4:187903568 G/C cg03647317 chr4:187891568 NA -0.53 -9.62 -0.47 1.82e-19 Lobe attachment (rater-scored or self-reported); CRC cis rs12594515 1.000 rs6493172 chr15:45987213 T/G cg01629716 chr15:45996671 NA 0.41 8.46 0.42 9.1e-16 Waist circumference;Weight; CRC cis rs8180040 0.966 rs2062278 chr3:47416761 C/T cg27129171 chr3:47204927 SETD2 0.58 8.96 0.44 2.52e-17 Colorectal cancer; CRC cis rs9381040 0.610 rs9381028 chr6:41025081 C/A cg25110423 chr6:41068646 NFYA;LOC221442 -0.38 -5.77 -0.3 1.79e-8 Alzheimer's disease (late onset); CRC trans rs877282 1.000 rs10904552 chr10:774326 A/G cg22713356 chr15:30763199 NA 1.13 14.52 0.62 2.9e-37 Uric acid levels; CRC cis rs4901869 0.966 rs12148052 chr14:59338970 C/T cg02291164 chr14:59296302 NA 0.36 6.67 0.35 1.09e-10 Panic disorder; CRC cis rs478304 0.593 rs9666878 chr11:65475816 A/C cg27068330 chr11:65405492 SIPA1 0.61 9.13 0.45 7.15e-18 Acne (severe); CRC cis rs7618501 0.633 rs4688757 chr3:50035323 T/C cg05623727 chr3:50126028 RBM5 0.45 7.52 0.38 5.18e-13 Intelligence (multi-trait analysis); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg03734322 chr17:1532856 SLC43A2 0.44 6.19 0.32 1.8e-9 Response to antipsychotic treatment; CRC cis rs78456975 0.941 rs13423300 chr2:1553809 C/A cg12573674 chr2:1569213 NA -0.77 -8.03 -0.4 1.78e-14 Placebo response in major depressive disorder (% change in symptom score); CRC trans rs4942242 0.626 rs7986998 chr13:44209916 G/A cg19169023 chr15:41853346 TYRO3 0.58 8.03 0.4 1.72e-14 Response to tocilizumab in rheumatoid arthritis; CRC cis rs4722166 0.604 rs2390715 chr7:22783878 A/C cg26061582 chr7:22766209 IL6 0.54 8.29 0.42 2.92e-15 Lung cancer; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg18231159 chr7:99214508 ZNF498 -0.4 -6.01 -0.31 4.87e-9 Myopia (pathological); CRC cis rs950169 1.000 rs12915234 chr15:84758301 G/A cg24253500 chr15:84953950 NA 0.38 6.44 0.33 4.32e-10 Schizophrenia; CRC cis rs9549328 0.643 rs4907567 chr13:113617533 C/T cg17524180 chr13:113633600 MCF2L 0.52 9.5 0.46 4.44e-19 Systolic blood pressure; CRC cis rs1552172 0.853 rs9728345 chr1:145597417 C/A cg11743829 chr1:145714124 CD160 -0.4 -5.9 -0.31 9.1e-9 Breast cancer; CRC cis rs853679 0.598 rs9380054 chr6:28067537 G/A cg12273811 chr6:28175739 NA 0.73 9.31 0.46 1.82e-18 Depression; CRC cis rs6484504 0.576 rs158136 chr11:31220712 C/T cg14844989 chr11:31128820 NA -0.34 -6.04 -0.32 4.26e-9 Red blood cell count; CRC cis rs6942756 0.513 rs10954224 chr7:128893513 T/A cg02491457 chr7:128862824 NA 0.52 7.55 0.38 4.27e-13 White matter hyperintensity burden; CRC cis rs597539 0.652 rs516425 chr11:68715675 G/A cg21963583 chr11:68658836 MRPL21 0.55 9.8 0.48 4.7e-20 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs9323205 0.765 rs2999386 chr14:51652628 G/T cg23942311 chr14:51606299 NA 0.62 9.92 0.48 1.79e-20 Cancer; CRC trans rs7395662 0.591 rs10838972 chr11:48611400 A/G cg15704280 chr7:45808275 SEPT13 -0.49 -6.85 -0.35 3.64e-11 HDL cholesterol; CRC cis rs2404602 0.655 rs4886507 chr15:77209694 T/C cg22467129 chr15:76604101 ETFA -0.38 -6.07 -0.32 3.49e-9 Blood metabolite levels; CRC cis rs4713118 0.513 rs149962 chr6:28015918 G/A cg06470822 chr6:28175283 NA 0.8 11.88 0.55 2.48e-27 Parkinson's disease; CRC cis rs2625529 0.618 rs6494992 chr15:72420750 G/C cg16672083 chr15:72433130 SENP8 0.44 6.77 0.35 6.03e-11 Red blood cell count; CRC cis rs1448094 0.967 rs10779222 chr12:86330775 G/A cg18827107 chr12:86230957 RASSF9 -0.37 -6.1 -0.32 2.98e-9 Major depressive disorder; CRC cis rs972578 0.967 rs9623737 chr22:43406680 G/T cg01576275 chr22:43409880 NA -0.5 -8.19 -0.41 5.69e-15 Mean platelet volume; CRC cis rs4862750 0.832 rs6836076 chr4:187899660 A/C cg27532560 chr4:187881888 NA -0.57 -10.58 -0.5 1.04e-22 Lobe attachment (rater-scored or self-reported); CRC cis rs17376456 0.825 rs55947981 chr5:93278104 G/T cg25358565 chr5:93447407 FAM172A 1.11 10.62 0.51 7.72e-23 Diabetic retinopathy; CRC cis rs9372498 0.536 rs9489399 chr6:118767147 C/A cg15382696 chr6:118971807 C6orf204 0.59 7.63 0.39 2.54e-13 Diastolic blood pressure; CRC cis rs11098499 0.863 rs11933966 chr4:120476715 G/A cg24375607 chr4:120327624 NA 0.48 7.19 0.37 4.29e-12 Corneal astigmatism; CRC cis rs853679 0.760 rs967005 chr6:28210688 C/T cg15845792 chr6:28175446 NA 0.74 7.78 0.39 9.45e-14 Depression; CRC cis rs7937682 0.632 rs4441050 chr11:111772506 C/T cg19812747 chr11:111475976 SIK2 0.43 6.3 0.33 9.57e-10 Primary sclerosing cholangitis; CRC cis rs17270561 0.609 rs7754733 chr6:25745049 C/G cg16482183 chr6:26056742 HIST1H1C 0.83 10.69 0.51 4.46e-23 Iron status biomarkers; CRC cis rs6963495 0.818 rs55794529 chr7:105165747 T/C cg02135003 chr7:105160482 PUS7 -0.91 -12.41 -0.56 2.87e-29 Bipolar disorder (body mass index interaction); CRC cis rs4604732 0.631 rs4411161 chr1:247632374 G/A cg12758973 chr1:247694275 LOC148824;OR2C3 0.39 5.73 0.3 2.21e-8 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CRC cis rs6665290 0.935 rs6693535 chr1:227197685 G/A cg10327440 chr1:227177885 CDC42BPA -1.05 -23.43 -0.79 4.22e-72 Myeloid white cell count; CRC cis rs10504229 0.645 rs35142596 chr8:58128151 C/T cg02290350 chr8:58132656 NA -0.58 -8.16 -0.41 7.29e-15 Developmental language disorder (linguistic errors); CRC cis rs6860806 0.507 rs272882 chr5:131669161 G/T cg18301423 chr5:131593218 PDLIM4 0.37 6.25 0.33 1.27e-9 Breast cancer; CRC cis rs853679 0.517 rs56364346 chr6:28050762 T/G cg02683197 chr6:28174875 NA 0.81 9.98 0.48 1.15e-20 Depression; CRC cis rs832540 0.898 rs331498 chr5:56249842 C/G cg18230493 chr5:56204884 C5orf35 0.42 6.27 0.33 1.15e-9 Coronary artery disease; CRC cis rs2072510 0.569 rs17677343 chr12:96397081 T/A cg15438951 chr12:96389694 HAL -0.49 -5.94 -0.31 7.38e-9 Metabolite levels (small molecules and protein measures); CRC trans rs800082 0.966 rs2575192 chr3:144281170 C/T cg24215973 chr2:240111563 HDAC4 0.52 6.94 0.36 2.1e-11 Smoking behavior; CRC cis rs9814567 0.806 rs4535271 chr3:134321669 T/A cg06109529 chr3:134205091 CEP63;ANAPC13 -0.7 -10.55 -0.5 1.36e-22 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs3733585 0.699 rs7699609 chr4:9961059 A/G cg00071950 chr4:10020882 SLC2A9 -0.54 -9.65 -0.47 1.42e-19 Cleft plate (environmental tobacco smoke interaction); CRC cis rs34375054 0.624 rs4073534 chr12:125671800 C/T cg05341575 chr12:125625032 AACS -0.4 -5.81 -0.31 1.47e-8 Post bronchodilator FEV1/FVC ratio; CRC cis rs7119 0.717 rs12898281 chr15:77786903 C/T cg17802220 chr15:77601643 NA 0.47 6.81 0.35 4.62e-11 Type 2 diabetes; CRC cis rs7107174 1.000 rs1318241 chr11:77930792 C/T cg02023728 chr11:77925099 USP35 0.49 7.24 0.37 3.29e-12 Testicular germ cell tumor; CRC trans rs10982213 0.830 rs2274163 chr9:117188714 C/T cg07682937 chr12:56546305 MYL6B 0.42 6.35 0.33 7.02e-10 Interleukin-6 levels; CRC cis rs3892630 0.817 rs12609866 chr19:33184412 C/T cg22980127 chr19:33182716 NUDT19 0.91 10.96 0.52 4.95e-24 Red blood cell traits; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg06476606 chr10:91061728 IFIT2 0.41 6.0 0.31 5.07e-9 Intelligence (multi-trait analysis); CRC trans rs3942852 0.696 rs4597030 chr11:48176573 G/A cg03929089 chr4:120376271 NA -0.72 -9.05 -0.45 1.27e-17 Acute lymphoblastic leukemia (childhood); CRC cis rs853679 0.517 rs9393898 chr6:28130376 G/T cg12273811 chr6:28175739 NA 0.72 9.03 0.45 1.47e-17 Depression; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg02853322 chr7:39989723 CDK13 0.38 5.98 0.31 5.9e-9 Intelligence (multi-trait analysis); CRC trans rs11031096 0.677 rs11031043 chr11:4145385 G/T cg22978087 chr8:24814126 NEFL 0.33 6.08 0.32 3.36e-9 Mean corpuscular volume;Mean corpuscular hemoglobin; CRC cis rs3087591 0.573 rs731758 chr17:29723000 C/G cg24425628 chr17:29625626 OMG;NF1 0.6 10.24 0.49 1.56e-21 Hip circumference; CRC trans rs6940638 0.956 rs72838268 chr6:27021173 A/G cg06606381 chr12:133084897 FBRSL1 -0.61 -6.41 -0.33 5.09e-10 Intelligence (multi-trait analysis); CRC cis rs6459804 0.566 rs76186270 chr7:157512420 C/T cg15733309 chr7:157513707 PTPRN2 0.4 6.57 0.34 1.96e-10 Bipolar disorder and schizophrenia; CRC cis rs7811142 1.000 rs7783550 chr7:99987805 A/G cg23667466 chr7:100026434 MEPCE;ZCWPW1 -0.7 -9.75 -0.47 6.64e-20 Platelet count; CRC cis rs10089 1.000 rs6887847 chr5:127473807 A/G cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.76 10.68 0.51 4.61e-23 Ileal carcinoids; CRC cis rs9487051 0.676 rs1829694 chr6:109593860 G/T cg21918786 chr6:109611834 NA -0.41 -7.17 -0.37 4.84e-12 Reticulocyte fraction of red cells; CRC cis rs2180341 0.960 rs7745944 chr6:127709574 A/G cg24812749 chr6:127587940 RNF146 0.96 13.46 0.6 3.28e-33 Breast cancer; CRC cis rs9914988 0.943 rs12453504 chr17:27119524 C/A cg07195577 chr17:27052828 TLCD1 0.42 6.02 0.32 4.64e-9 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs7809950 0.784 rs7803102 chr7:107248929 T/G cg23024343 chr7:107201750 COG5 0.64 9.16 0.45 5.72e-18 Coronary artery disease; CRC cis rs9457247 1.000 rs376574 chr6:167389956 A/T cg23791538 chr6:167370224 RNASET2 -0.38 -5.97 -0.31 6.08e-9 Crohn's disease; CRC cis rs919433 0.680 rs8539 chr2:198362018 A/G cg10820045 chr2:198174542 NA 0.4 6.64 0.34 1.3e-10 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC cis rs12791968 0.527 rs4755300 chr11:45013421 C/T cg11846598 chr11:44996168 LOC221122 0.48 6.15 0.32 2.28e-9 Inhibitory control; CRC cis rs11098499 0.863 rs7669520 chr4:120515278 T/C cg24375607 chr4:120327624 NA 0.49 7.38 0.38 1.32e-12 Corneal astigmatism; CRC cis rs4332037 0.586 rs62442944 chr7:2015047 T/G cg23378565 chr7:2036160 MAD1L1 -0.49 -6.96 -0.36 1.8e-11 Bipolar disorder; CRC cis rs921968 0.565 rs62191658 chr2:219630294 A/G cg02176678 chr2:219576539 TTLL4 -0.39 -6.31 -0.33 8.79e-10 Mean corpuscular hemoglobin concentration; CRC cis rs6502050 0.635 rs11867440 chr17:80147185 A/T cg19223190 chr17:80058835 NA 0.39 6.21 0.32 1.62e-9 Life satisfaction; CRC cis rs738322 0.967 rs4383 chr22:38570927 C/G cg17652424 chr22:38574118 PLA2G6 -0.22 -6.73 -0.35 7.71e-11 Cutaneous nevi; CRC cis rs3736485 0.934 rs17609666 chr15:51858038 G/T cg08986416 chr15:51914746 DMXL2 -0.45 -6.56 -0.34 2.12e-10 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs7618501 0.633 rs6446189 chr3:50008566 A/G cg24308560 chr3:49941425 MST1R -0.51 -8.36 -0.42 1.83e-15 Intelligence (multi-trait analysis); CRC cis rs344364 0.511 rs1742462 chr16:1946062 A/C cg09830162 chr16:1889614 FAHD1;C16orf73 -0.74 -9.05 -0.45 1.3e-17 Glomerular filtration rate in chronic kidney disease; CRC cis rs4819052 0.851 rs13047104 chr21:46673562 T/G cg19498844 chr21:46707878 POFUT2;LOC642852 0.78 11.28 0.53 3.77e-25 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs5758659 0.652 rs133347 chr22:42423645 A/T cg15557168 chr22:42548783 NA -0.34 -5.68 -0.3 2.9e-8 Cognitive function; CRC cis rs11608355 0.597 rs2304548 chr12:109795166 T/G cg19025524 chr12:109796872 NA -0.61 -10.02 -0.48 8.4e-21 Neuroticism; CRC cis rs6879260 1.000 rs7725605 chr5:179732678 T/G cg13944838 chr5:179740914 GFPT2 -0.72 -11.85 -0.55 3.15e-27 Height; CRC cis rs7107174 1.000 rs4492844 chr11:78026516 A/G cg02023728 chr11:77925099 USP35 0.5 7.07 0.36 9.63e-12 Testicular germ cell tumor; CRC cis rs4474465 1.000 rs7128417 chr11:78205974 C/G cg27205649 chr11:78285834 NARS2 0.47 5.79 0.3 1.61e-8 Alzheimer's disease (survival time); CRC cis rs10464366 0.571 rs4723825 chr7:39157627 G/C cg15212455 chr7:39170539 POU6F2 0.5 6.65 0.34 1.21e-10 IgG glycosylation; CRC cis rs3733585 0.631 rs4697924 chr4:10124239 A/G cg00071950 chr4:10020882 SLC2A9 -0.5 -7.71 -0.39 1.54e-13 Cleft plate (environmental tobacco smoke interaction); CRC cis rs9916302 0.904 rs7223331 chr17:37482930 A/G cg00129232 chr17:37814104 STARD3 0.53 7.91 0.4 3.96e-14 Glomerular filtration rate (creatinine); CRC trans rs10021731 0.718 rs1460772 chr4:115408184 C/T cg25927708 chr2:119603813 EN1 -0.32 -6.05 -0.32 3.96e-9 Optic disc area; CRC cis rs6662572 0.737 rs72677530 chr1:46529677 G/A cg08644498 chr1:46502608 NA 0.45 7.25 0.37 3.09e-12 Blood protein levels; CRC cis rs4555082 0.874 rs113291192 chr14:105738181 C/T cg13114125 chr14:105738426 BRF1 -0.81 -11.89 -0.55 2.37e-27 Mean platelet volume;Platelet distribution width; CRC cis rs853679 0.517 rs9380056 chr6:28104476 C/T cg12273811 chr6:28175739 NA 0.73 9.36 0.46 1.34e-18 Depression; CRC trans rs11722228 0.508 rs3822246 chr4:10094698 G/A cg26043149 chr18:55253948 FECH 1.13 17.37 0.69 1.99e-48 Gout;Urate levels;Serum uric acid levels; CRC cis rs1218582 0.600 rs72702224 chr1:154911689 G/A cg09359103 chr1:154839909 KCNN3 -0.72 -11.24 -0.53 5.05e-25 Prostate cancer; CRC cis rs7659604 0.539 rs56159666 chr4:122782879 G/A cg06713675 chr4:122721982 EXOSC9 -0.51 -8.29 -0.42 2.97e-15 Type 2 diabetes; CRC cis rs3764563 1.000 rs3764563 chr19:15724203 A/G cg20725493 chr19:15740067 CYP4F8 -0.68 -6.63 -0.34 1.36e-10 Inflammatory biomarkers; CRC trans rs7615952 0.599 rs16834938 chr3:125706046 C/T cg07211511 chr3:129823064 LOC729375 -0.75 -10.67 -0.51 5.19e-23 Blood pressure (smoking interaction); CRC cis rs853679 0.882 rs9366717 chr6:28191057 C/T cg03623178 chr6:28175578 NA 0.9 7.35 0.38 1.55e-12 Depression; CRC cis rs1003719 0.680 rs3737540 chr21:38523266 C/A cg10648535 chr21:38446584 PIGP;TTC3 -0.46 -6.38 -0.33 5.93e-10 Eye color traits; CRC cis rs79349575 0.749 rs1057902 chr17:47005588 C/T cg22482690 chr17:47019901 SNF8 0.46 7.65 0.39 2.26e-13 Type 2 diabetes; CRC trans rs66887589 0.560 rs9684327 chr4:120365441 A/G cg25214090 chr10:38739885 LOC399744 0.42 6.57 0.34 1.97e-10 Diastolic blood pressure; CRC cis rs4819052 1.000 rs3746980 chr21:46711580 C/T cg19498844 chr21:46707878 POFUT2;LOC642852 0.86 11.4 0.53 1.31e-25 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs6502050 0.835 rs6502069 chr17:80112599 G/T cg13198984 chr17:80129470 CCDC57 0.46 8.16 0.41 6.94e-15 Life satisfaction; CRC cis rs3815700 1.000 rs7248273 chr19:33096816 C/T cg02997394 chr19:33096574 ANKRD27 0.69 7.51 0.38 5.74e-13 Eosinophilic esophagitis; CRC trans rs1814175 0.585 rs4881661 chr11:50000117 A/G cg15704280 chr7:45808275 SEPT13 -0.92 -16.92 -0.68 1.2e-46 Height; CRC cis rs2075371 0.547 rs12666682 chr7:134021784 C/A cg20476274 chr7:133979776 SLC35B4 0.51 7.55 0.38 4.29e-13 Mean platelet volume; CRC cis rs4654899 1.000 rs6689819 chr1:21472395 A/T cg02927042 chr1:21476669 EIF4G3 -0.47 -7.57 -0.39 3.77e-13 Superior frontal gyrus grey matter volume; CRC cis rs1971762 0.527 rs7952858 chr12:54039692 C/G cg06632207 chr12:54070931 ATP5G2 0.46 7.82 0.4 7.18e-14 Height; CRC cis rs2839186 0.500 rs13052701 chr21:47660045 A/T cg02776659 chr21:47717406 C21orf57 -0.38 -6.17 -0.32 1.99e-9 Testicular germ cell tumor; CRC cis rs4604732 0.536 rs61184655 chr1:247651342 T/C cg12758973 chr1:247694275 LOC148824;OR2C3 0.45 6.93 0.36 2.29e-11 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CRC cis rs2075371 0.579 rs11766422 chr7:134018160 T/C cg02659138 chr7:134003124 SLC35B4 0.36 5.74 0.3 2.16e-8 Mean platelet volume; CRC cis rs73206853 0.841 rs56379265 chr12:110956370 G/A cg12870014 chr12:110450643 ANKRD13A 0.71 7.68 0.39 1.86e-13 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC cis rs2227564 0.620 rs3812637 chr10:75568846 C/T cg00564723 chr10:75632066 CAMK2G -0.31 -7.73 -0.39 1.3e-13 Crohn's disease;Inflammatory bowel disease; CRC cis rs7777484 0.500 rs757787 chr7:2836355 G/A cg19717773 chr7:2847554 GNA12 -0.51 -8.8 -0.44 7.93e-17 Height; CRC cis rs6429082 0.818 rs291344 chr1:235663860 C/G cg26050004 chr1:235667680 B3GALNT2 -0.59 -8.08 -0.41 1.21e-14 Adiposity; CRC cis rs7811142 0.830 rs11769057 chr7:99964661 A/G cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.94 12.66 0.57 3.42e-30 Platelet count; CRC cis rs4434138 0.683 rs13063160 chr3:52602274 T/C cg10802521 chr3:52805072 NEK4 -0.57 -9.13 -0.45 6.95e-18 Intelligence (multi-trait analysis); CRC trans rs12599106 0.629 rs1391904 chr16:34548934 C/T cg21548813 chr6:291882 DUSP22 -0.52 -7.24 -0.37 3.21e-12 Menopause (age at onset); CRC trans rs35110281 0.782 rs1454650 chr21:45012353 C/T cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.49 8.2 0.41 5.33e-15 Mean corpuscular volume; CRC cis rs6500395 0.962 rs9972682 chr16:48686644 T/G cg04672837 chr16:48644449 N4BP1 0.42 6.0 0.31 5.26e-9 Response to tocilizumab in rheumatoid arthritis; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg20488697 chr17:79885644 LOC92659;MAFG 0.43 6.0 0.31 5.15e-9 Response to antipsychotic treatment; CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg06458679 chr21:46974866 NA 0.38 6.05 0.32 4.02e-9 Obesity-related traits; CRC cis rs9443645 0.869 rs1507154 chr6:79503700 C/T cg11833968 chr6:79620685 NA -0.35 -6.24 -0.33 1.38e-9 Intelligence (multi-trait analysis); CRC cis rs7843479 0.965 rs11785657 chr8:21859485 G/A cg17168535 chr8:21777572 XPO7 0.55 8.77 0.44 9.97e-17 Mean corpuscular volume; CRC cis rs7703744 0.597 rs73237297 chr5:118691121 G/T cg02283238 chr5:118691126 TNFAIP8 0.46 6.49 0.34 3.07e-10 Lobe attachment (rater-scored or self-reported); CRC cis rs13064411 0.518 rs1471884 chr3:113212041 G/A cg18753928 chr3:113234510 CCDC52 -0.48 -7.67 -0.39 2.01e-13 Response to simvastatin treatment (PCSK9 protein level change); CRC trans rs4942242 1.000 rs9562501 chr13:44205683 C/T cg19169023 chr15:41853346 TYRO3 -0.5 -7.73 -0.39 1.36e-13 Response to tocilizumab in rheumatoid arthritis; CRC cis rs76878669 0.561 rs3177514 chr11:66130358 T/G cg18002602 chr11:66138449 SLC29A2 0.28 6.05 0.32 3.93e-9 Educational attainment (years of education); CRC cis rs2836974 0.931 rs2836972 chr21:40652142 G/A cg06238570 chr21:40685208 BRWD1 0.79 10.86 0.51 1.11e-23 Cognitive function; CRC cis rs6951245 0.744 rs10265758 chr7:1172518 C/T cg24642844 chr7:1081250 C7orf50 -0.66 -8.5 -0.42 6.91e-16 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs4731207 0.698 rs9886177 chr7:124513450 C/T cg23710748 chr7:124431027 NA -0.38 -6.08 -0.32 3.42e-9 Cutaneous malignant melanoma; CRC cis rs4746091 1.000 rs61463062 chr10:73398844 G/A cg22763136 chr10:73395000 CDH23 0.4 5.74 0.3 2.11e-8 Selective IgA deficiency; CRC cis rs9583531 0.600 rs6492306 chr13:111361693 G/A cg24331049 chr13:111365604 ING1 0.56 7.78 0.39 9.7e-14 Coronary artery disease; CRC cis rs1552244 1.000 rs6442150 chr3:10122575 T/C cg02579736 chr3:10068473 FANCD2;CIDECP 1.02 13.77 0.6 2.25e-34 Alzheimer's disease; CRC cis rs7937682 0.924 rs1784782 chr11:111525764 A/C cg19812747 chr11:111475976 SIK2 -0.59 -10.07 -0.49 5.54e-21 Primary sclerosing cholangitis; CRC cis rs6860806 0.661 rs4705929 chr5:131584178 G/T cg11843238 chr5:131593191 PDLIM4 0.43 8.18 0.41 6.34e-15 Breast cancer; CRC trans rs1814175 0.676 rs1851859 chr11:49860405 A/T cg15704280 chr7:45808275 SEPT13 -0.94 -16.68 -0.68 1.07e-45 Height; CRC cis rs9649213 0.593 rs35983874 chr7:97916461 C/T cg24562669 chr7:97807699 LMTK2 0.44 7.5 0.38 6.18e-13 Prostate cancer (SNP x SNP interaction); CRC cis rs1401999 0.864 rs4148563 chr3:183725999 T/C cg20387954 chr3:183756860 HTR3D 0.46 7.91 0.4 3.89e-14 Anterior chamber depth; CRC cis rs1881797 1.000 rs1881797 chr1:247689532 A/G cg11166453 chr1:247681781 NA 0.5 9.45 0.46 6.59e-19 Acute lymphoblastic leukemia (childhood); CRC cis rs9368481 0.700 rs6911401 chr6:26913214 C/G cg18278486 chr6:26987575 LOC100270746;C6orf41 0.41 6.61 0.34 1.55e-10 Autism spectrum disorder or schizophrenia; CRC cis rs763121 0.853 rs5750664 chr22:39072769 C/T cg06544989 chr22:39130855 UNC84B 0.45 6.9 0.36 2.7e-11 Menopause (age at onset); CRC trans rs2018683 1.000 rs740252 chr7:28997765 C/G cg19402173 chr7:128379420 CALU -0.61 -9.72 -0.47 8.35e-20 Response to irinotecan and platinum-based chemotherapy in non-small-cell lung cancer; CRC cis rs947211 0.950 rs1775145 chr1:205756143 C/A cg07157834 chr1:205819609 PM20D1 0.43 5.82 0.31 1.41e-8 Parkinson's disease; CRC trans rs9858542 0.953 rs9837027 chr3:49597013 C/T cg21582582 chr3:182698605 DCUN1D1 -0.54 -6.86 -0.35 3.51e-11 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs7633770 0.786 rs4234464 chr3:46679675 C/T cg11219411 chr3:46661640 NA -0.51 -8.09 -0.41 1.13e-14 Coronary artery disease; CRC cis rs73200209 0.744 rs17498543 chr12:116581796 T/C cg01776926 chr12:116560359 MED13L -0.62 -7.21 -0.37 3.98e-12 Total body bone mineral density; CRC cis rs6076065 0.723 rs2253924 chr20:23388020 G/A cg11657817 chr20:23433608 CST11 0.43 6.42 0.33 4.86e-10 Facial morphology (factor 15, philtrum width); CRC cis rs7618915 0.547 rs33967311 chr3:52683864 G/T cg11645453 chr3:52864694 ITIH4 0.35 6.15 0.32 2.25e-9 Bipolar disorder; CRC cis rs12586317 0.586 rs74243590 chr14:35513246 G/A cg16230307 chr14:35515116 FAM177A1 0.92 10.74 0.51 2.95e-23 Psoriasis; CRC cis rs10883723 0.773 rs2296578 chr10:104240974 C/G cg04362960 chr10:104952993 NT5C2 -0.41 -5.62 -0.3 4.05e-8 Allergic disease (asthma, hay fever or eczema); CRC trans rs2243480 1.000 rs2533288 chr7:66056711 C/G cg10756647 chr7:56101905 PSPH 0.76 7.88 0.4 4.86e-14 Diabetic kidney disease; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg03087334 chr18:33077969 INO80C 0.49 6.96 0.36 1.83e-11 Response to antipsychotic treatment; CRC cis rs10504229 0.683 rs6999131 chr8:58127052 C/A cg11062466 chr8:58055876 NA 0.54 6.94 0.36 2.04e-11 Developmental language disorder (linguistic errors); CRC cis rs7940866 0.801 rs2113928 chr11:130835975 A/G cg12179176 chr11:130786555 SNX19 0.58 8.74 0.43 1.21e-16 Schizophrenia; CRC cis rs929354 0.772 rs1182448 chr7:157021415 G/A cg17757837 chr7:157058334 UBE3C -0.75 -12.98 -0.58 2.18e-31 Body mass index; CRC cis rs7503807 0.515 rs12945216 chr17:78670642 C/T cg00549398 chr17:78725201 RPTOR 0.43 5.65 0.3 3.41e-8 Obesity; CRC cis rs4713118 0.824 rs2179095 chr6:27750858 A/G cg19041857 chr6:27730383 NA 0.48 6.62 0.34 1.46e-10 Parkinson's disease; CRC cis rs763014 1.000 rs2269558 chr16:682250 C/T cg00802000 chr16:706648 WDR90 -0.42 -6.01 -0.31 4.83e-9 Height; CRC cis rs172166 0.637 rs1071893 chr6:28167635 G/C cg23161317 chr6:28129485 ZNF389 0.47 6.84 0.35 3.86e-11 Cardiac Troponin-T levels; CRC cis rs13108904 0.967 rs62293658 chr4:1276416 T/C cg20887711 chr4:1340912 KIAA1530 -0.47 -7.21 -0.37 3.91e-12 Obesity-related traits; CRC cis rs2949837 0.504 rs2342396 chr7:45968087 C/G cg23193639 chr7:45961078 IGFBP3 0.37 6.31 0.33 9.19e-10 Sitting height ratio; CRC cis rs9443645 0.527 rs10943596 chr6:79575292 C/T cg09184832 chr6:79620586 NA -0.47 -8.22 -0.41 4.67e-15 Intelligence (multi-trait analysis); CRC cis rs7727544 0.660 rs272886 chr5:131665840 T/C cg07395648 chr5:131743802 NA -0.39 -6.15 -0.32 2.28e-9 Blood metabolite levels; CRC cis rs66569888 0.507 rs11673736 chr2:106886935 T/C cg16099169 chr2:106886729 NA -0.6 -10.89 -0.51 8.91e-24 Facial morphology (factor 23); CRC cis rs11676348 0.755 rs1008562 chr2:219026972 G/C cg00012203 chr2:219082015 ARPC2 0.44 6.59 0.34 1.77e-10 Ulcerative colitis; CRC cis rs9549367 0.713 rs556990 chr13:113845059 T/C cg00898013 chr13:113819073 PROZ 0.5 7.43 0.38 9.39e-13 Platelet distribution width; CRC cis rs11155671 0.530 rs7774787 chr6:150209432 G/A cg13206674 chr6:150067644 NUP43 0.49 7.03 0.36 1.22e-11 Testicular germ cell tumor; CRC cis rs2073499 1.000 rs3806708 chr3:50306249 T/C cg09545109 chr3:50388910 TUSC4;CYB561D2 0.63 5.94 0.31 7.12e-9 Schizophrenia; CRC cis rs1451375 0.617 rs10267323 chr7:50591424 A/G cg14593290 chr7:50529359 DDC 0.64 8.51 0.42 6.25e-16 Malaria; CRC cis rs9926296 0.605 rs12448860 chr16:89849629 T/A cg04287289 chr16:89883240 FANCA 0.83 15.03 0.64 3.12e-39 Vitiligo; CRC cis rs2732480 0.523 rs34286639 chr12:48629044 C/T cg21466736 chr12:48725269 NA -0.56 -8.32 -0.42 2.36e-15 Hemoglobin concentration;Red blood cell count;Hematocrit; CRC cis rs1448094 0.511 rs59668915 chr12:86197170 C/T cg00310523 chr12:86230176 RASSF9 0.35 6.0 0.31 5.08e-9 Major depressive disorder; CRC cis rs1348850 0.567 rs7605493 chr2:178534983 C/G cg22681709 chr2:178499509 PDE11A -0.43 -7.92 -0.4 3.58e-14 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs9527 0.590 rs11191572 chr10:104893137 A/G cg04362960 chr10:104952993 NT5C2 0.6 8.32 0.42 2.32e-15 Arsenic metabolism; CRC cis rs4689592 0.622 rs2276968 chr4:7070118 T/G cg26116260 chr4:7069785 GRPEL1 0.92 12.42 0.56 2.67e-29 Monocyte percentage of white cells; CRC trans rs2303319 0.504 rs62190168 chr2:162322012 A/G cg19471553 chr17:41393123 NA -0.7 -6.07 -0.32 3.48e-9 Cognitive function; CRC trans rs2727020 0.521 rs7114564 chr11:49571231 C/T cg15704280 chr7:45808275 SEPT13 0.74 10.15 0.49 3.08e-21 Coronary artery disease; CRC cis rs12701220 0.895 rs10262866 chr7:1019536 G/A cg26769984 chr7:1090371 C7orf50 0.58 7.38 0.38 1.31e-12 Bronchopulmonary dysplasia; CRC cis rs4900538 0.927 rs1190547 chr14:102905087 G/C cg18135206 chr14:102964638 TECPR2 -0.97 -19.43 -0.73 1.47e-56 Mean corpuscular volume;Mean corpuscular hemoglobin; CRC cis rs290268 0.838 rs290987 chr9:93563267 T/A cg02608019 chr9:93564028 SYK 0.46 7.24 0.37 3.27e-12 Platelet count; CRC cis rs35000415 0.938 rs35188261 chr7:128683539 G/A cg19972273 chr7:128594194 NA 0.69 6.28 0.33 1.05e-9 Systemic lupus erythematosus; CRC trans rs9858542 0.951 rs1800668 chr3:49395757 G/A cg21659725 chr3:3221576 CRBN -0.63 -8.62 -0.43 2.85e-16 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs11212617 1.000 rs2884030 chr11:108281903 C/T cg14761454 chr11:108092087 ATM;NPAT 0.45 6.89 0.36 2.79e-11 Response to metformin in type 2 diabetes (glycemic); CRC cis rs539514 0.516 rs2273996 chr13:76410725 A/G cg04757411 chr13:76259545 LMO7 0.34 5.68 0.3 3e-8 Type 1 diabetes; CRC cis rs78456975 0.941 rs11886649 chr2:1567757 A/G cg12573674 chr2:1569213 NA -0.74 -7.89 -0.4 4.59e-14 Placebo response in major depressive disorder (% change in symptom score); CRC trans rs10504390 0.585 rs80151640 chr8:66537841 C/T cg26403416 chr21:43771339 TFF2 0.6 6.14 0.32 2.38e-9 IgG glycosylation; CRC cis rs9372498 0.536 rs9489477 chr6:118946192 T/G cg07617317 chr6:118971624 C6orf204 0.47 5.68 0.3 2.91e-8 Diastolic blood pressure; CRC cis rs873946 0.564 rs35831787 chr10:134546346 T/C cg18305652 chr10:134549665 INPP5A 0.51 7.31 0.37 2.06e-12 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CRC cis rs2204008 0.713 rs2320522 chr12:38251438 C/T cg13010199 chr12:38710504 ALG10B 0.45 5.75 0.3 2.07e-8 Bladder cancer; CRC cis rs9649213 0.593 rs56286037 chr7:98019522 C/T cg08684580 chr7:98029266 BAIAP2L1 -0.31 -5.6 -0.3 4.43e-8 Prostate cancer (SNP x SNP interaction); CRC cis rs6502050 0.835 rs34867501 chr17:80121358 T/C cg02741985 chr17:80059408 CCDC57 0.43 7.15 0.37 5.59e-12 Life satisfaction; CRC cis rs2019137 0.936 rs2305133 chr2:113956821 C/G cg12889195 chr2:113992843 PAX8;LOC440839;LOC654433 -0.51 -7.23 -0.37 3.32e-12 Lymphocyte counts; CRC cis rs9467773 1.000 rs1321479 chr6:26501897 C/T cg09904177 chr6:26538194 HMGN4 -0.82 -14.07 -0.61 1.56e-35 Intelligence (multi-trait analysis); CRC cis rs9549260 0.755 rs2755214 chr13:41149345 T/G cg21288729 chr13:41239152 FOXO1 0.39 5.97 0.31 6.09e-9 Red blood cell count; CRC cis rs2014572 1.000 rs2014572 chr19:57760018 G/A cg24459738 chr19:57751996 ZNF805 -0.58 -9.16 -0.45 5.88e-18 Hyperactive-impulsive symptoms; CRC cis rs10504229 0.683 rs11774697 chr8:58133119 G/A cg24829409 chr8:58192753 C8orf71 -0.63 -8.01 -0.4 1.96e-14 Developmental language disorder (linguistic errors); CRC cis rs747650 0.532 rs3922684 chr11:47121176 T/C cg19486271 chr11:47235900 DDB2 0.44 5.89 0.31 9.76e-9 Acne (severe); CRC cis rs6570726 0.764 rs9386125 chr6:145911677 C/T cg23711669 chr6:146136114 FBXO30 0.68 11.28 0.53 3.51e-25 Lobe attachment (rater-scored or self-reported); CRC cis rs2228479 0.702 rs11646374 chr16:89857935 G/A cg19635926 chr16:89946313 TCF25 0.65 6.09 0.32 3.17e-9 Skin colour saturation; CRC cis rs611744 0.647 rs13280487 chr8:109270263 G/C cg18478394 chr8:109455254 TTC35 0.4 6.24 0.33 1.34e-9 Dupuytren's disease; CRC cis rs9359856 0.564 rs72917989 chr6:90470385 A/T cg13799429 chr6:90582589 CASP8AP2 -0.75 -7.58 -0.39 3.44e-13 Bipolar disorder; CRC cis rs8105895 0.935 rs7252547 chr19:22305481 T/C cg02912127 chr19:22235281 ZNF257 -0.42 -5.74 -0.3 2.21e-8 Body mass index (change over time); CRC cis rs11190604 1.000 rs10883499 chr10:102232188 T/A cg16342193 chr10:102329863 NA -0.36 -5.91 -0.31 8.37e-9 Palmitoleic acid (16:1n-7) levels; CRC cis rs4665809 0.590 rs1865324 chr2:26417533 C/A cg27170947 chr2:26402098 FAM59B -0.59 -7.62 -0.39 2.79e-13 Gut microbiome composition (summer); CRC cis rs875971 0.862 rs57866200 chr7:65565392 A/G cg18876405 chr7:65276391 NA -0.51 -8.49 -0.42 6.96e-16 Aortic root size; CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg07151637 chr22:32149913 DEPDC5 0.36 6.32 0.33 8.61e-10 Obesity-related traits; CRC cis rs4481887 0.893 rs4297335 chr1:248473421 C/T cg00666640 chr1:248458726 OR2T12 0.48 8.14 0.41 7.98e-15 Common traits (Other); CRC trans rs208520 0.802 rs208499 chr6:66932146 C/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.92 -11.96 -0.55 1.28e-27 Exhaled nitric oxide output; CRC cis rs7107174 0.901 rs2450133 chr11:77925759 A/C cg02023728 chr11:77925099 USP35 0.54 8.2 0.41 5.55e-15 Testicular germ cell tumor; CRC cis rs28386778 0.897 rs6504184 chr17:61842408 A/T cg11494091 chr17:61959527 GH2 0.63 10.73 0.51 3.01e-23 Prudent dietary pattern; CRC cis rs6565180 0.926 rs4787643 chr16:30393660 G/A cg17640201 chr16:30407289 ZNF48 0.84 13.94 0.61 4.86e-35 Tonsillectomy; CRC cis rs4819852 1.000 rs4819852 chr22:19988167 G/A cg07821417 chr22:19972146 ARVCF 0.45 5.82 0.31 1.38e-8 Pulse pressure; CRC cis rs11105298 0.891 rs10506972 chr12:89861529 T/C cg08166232 chr12:89918718 WDR51B;GALNT4 -0.61 -7.77 -0.39 1.01e-13 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; CRC cis rs262150 0.659 rs2527236 chr7:158796644 C/T cg10570241 chr7:158785291 NA 0.45 7.75 0.39 1.16e-13 Facial morphology (factor 20); CRC cis rs9894429 1.000 rs7406003 chr17:79597597 C/T cg18240062 chr17:79603768 NPLOC4 0.56 9.43 0.46 7.75e-19 Eye color traits; CRC cis rs16975963 0.793 rs56672492 chr19:38448231 T/C cg15135657 chr19:38346511 NA -0.42 -5.65 -0.3 3.55e-8 Longevity; CRC cis rs1862618 0.853 rs2548665 chr5:56131805 T/A cg03609598 chr5:56110824 MAP3K1 -0.81 -10.01 -0.48 8.99e-21 Initial pursuit acceleration; CRC cis rs2976388 1.000 rs2978982 chr8:143763490 T/C cg20041105 chr8:143859282 LYNX1 -0.32 -5.66 -0.3 3.28e-8 Urinary tract infection frequency; CRC cis rs10256972 0.591 rs6950319 chr7:1161324 A/G cg16145915 chr7:1198662 ZFAND2A -0.43 -8.38 -0.42 1.52e-15 Longevity;Endometriosis; CRC cis rs16852403 0.548 rs543452 chr1:178220878 A/G cg00404053 chr1:178313656 RASAL2 -0.5 -6.49 -0.34 3.08e-10 Childhood ear infection; CRC cis rs10504229 1.000 rs78953746 chr8:58170608 A/G cg01721255 chr8:58191610 C8orf71 0.5 6.18 0.32 1.87e-9 Developmental language disorder (linguistic errors); CRC cis rs7833986 0.501 rs2953897 chr8:56980569 C/T cg23139584 chr8:56987506 RPS20;SNORD54 0.91 12.57 0.57 7.49e-30 Height; CRC cis rs4563143 0.647 rs73029014 chr19:29257655 G/C cg03161606 chr19:29218774 NA 0.52 6.52 0.34 2.68e-10 Methadone dose in opioid dependence; CRC cis rs10504229 1.000 rs67546820 chr8:58168567 G/A cg24829409 chr8:58192753 C8orf71 -0.65 -11.09 -0.52 1.74e-24 Developmental language disorder (linguistic errors); CRC cis rs10426930 0.700 rs8106479 chr19:5003940 G/C cg25246084 chr19:4971487 KDM4B -0.34 -5.77 -0.3 1.81e-8 Monocyte percentage of white cells; CRC cis rs881375 0.967 rs7864019 chr9:123692868 A/T cg14255062 chr9:123606675 PSMD5;LOC253039 0.4 5.81 0.31 1.47e-8 Rheumatoid arthritis; CRC cis rs9894429 0.646 rs6565609 chr17:79592267 G/A cg21984481 chr17:79567631 NPLOC4 -0.45 -7.79 -0.39 8.81e-14 Eye color traits; CRC cis rs911555 0.755 rs17841064 chr14:103900609 A/G cg12935359 chr14:103987150 CKB -0.54 -8.68 -0.43 1.81e-16 Intelligence (multi-trait analysis); CRC cis rs9611519 0.929 rs73174660 chr22:41437304 T/C cg03806693 chr22:41940476 POLR3H -0.58 -7.41 -0.38 1.1e-12 Neuroticism; CRC cis rs735396 0.595 rs1169279 chr12:121455873 C/T cg25281562 chr12:121454272 C12orf43 0.43 6.03 0.32 4.41e-9 N-glycan levels; CRC cis rs6540559 0.546 rs57315825 chr1:210030197 C/T cg25204440 chr1:209979598 IRF6 0.47 5.79 0.3 1.62e-8 Cleft lip with or without cleft palate; CRC cis rs7208859 0.673 rs11653955 chr17:29033292 C/A cg13385521 chr17:29058706 SUZ12P 0.69 7.68 0.39 1.79e-13 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs2303745 0.589 rs891018 chr19:17396761 C/T cg15110403 chr19:17392923 ANKLE1 0.36 5.85 0.31 1.21e-8 Systemic lupus erythematosus; CRC cis rs7746199 0.668 rs7749305 chr6:27446566 T/C cg19041857 chr6:27730383 NA -0.77 -6.87 -0.35 3.3e-11 Gait speed in old age;Autism spectrum disorder or schizophrenia; CRC cis rs7043114 0.525 rs10739927 chr9:95052081 G/T cg14631576 chr9:95140430 CENPP -0.3 -5.76 -0.3 1.92e-8 Height; CRC cis rs12586317 0.547 rs28577270 chr14:35498443 G/A cg05294307 chr14:35346193 BAZ1A -0.69 -7.47 -0.38 7.35e-13 Psoriasis; CRC trans rs11098499 0.909 rs78332141 chr4:120375782 C/T cg25214090 chr10:38739885 LOC399744 0.64 9.77 0.47 5.94e-20 Corneal astigmatism; CRC cis rs1448094 0.547 rs7954472 chr12:86166258 T/C cg00310523 chr12:86230176 RASSF9 0.38 6.11 0.32 2.84e-9 Major depressive disorder; CRC cis rs2710642 0.925 rs72807578 chr2:63008044 G/A cg17519650 chr2:63277830 OTX1 -0.49 -6.59 -0.34 1.75e-10 LDL cholesterol levels;LDL cholesterol; CRC cis rs7927771 0.524 rs7101597 chr11:47797917 A/T cg20307385 chr11:47447363 PSMC3 0.46 6.61 0.34 1.52e-10 Subjective well-being; CRC cis rs7493 0.950 rs56265549 chr7:95047155 G/A cg20119798 chr7:94954144 PON1 -0.49 -6.26 -0.33 1.21e-9 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs300703 1.000 rs300703 chr2:239416 C/T cg21211680 chr2:198530 NA 0.98 8.39 0.42 1.44e-15 Blood protein levels; CRC cis rs7666738 0.830 rs1534319 chr4:98964804 T/C cg05340658 chr4:99064831 C4orf37 0.61 9.45 0.46 6.55e-19 Colonoscopy-negative controls vs population controls; CRC trans rs2303319 0.504 rs62189048 chr2:162613494 G/C cg18122310 chr12:50236657 BCDIN3D -0.73 -6.35 -0.33 7.23e-10 Cognitive function; CRC cis rs798554 0.644 rs1639040 chr7:2884116 G/T cg04166393 chr7:2884313 GNA12 0.53 7.25 0.37 3.02e-12 Height; CRC cis rs10751667 1.000 rs10902246 chr11:953674 T/C cg01483505 chr11:975446 AP2A2 0.4 6.02 0.31 4.71e-9 Alzheimer's disease (late onset); CRC cis rs3749237 1.000 rs2307021 chr3:49765483 C/G cg05072774 chr3:49840536 C3orf54 -0.44 -5.68 -0.3 2.95e-8 Resting heart rate; CRC cis rs17818399 0.533 rs13420857 chr2:46798005 C/G cg26688816 chr2:46740690 ATP6V1E2 0.49 7.42 0.38 1.01e-12 Height; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg21721210 chr19:39574878 PAPL 0.33 6.42 0.33 4.69e-10 Liver disease severity in Alagille syndrome; CRC cis rs2836950 0.565 rs2836942 chr21:40591381 A/G cg06238570 chr21:40685208 BRWD1 -0.6 -8.78 -0.44 8.92e-17 Menarche (age at onset); CRC cis rs9325144 0.560 rs11183150 chr12:38674698 A/G cg13010199 chr12:38710504 ALG10B -0.42 -6.16 -0.32 2.09e-9 Morning vs. evening chronotype; CRC cis rs2013441 1.000 rs4924809 chr17:20044673 C/T cg13482628 chr17:19912719 NA 0.41 6.33 0.33 7.87e-10 Obesity-related traits; CRC cis rs9733 0.525 rs11584184 chr1:150695689 A/T cg10589385 chr1:150898437 SETDB1 0.28 5.96 0.31 6.66e-9 Tonsillectomy; CRC cis rs2228479 0.702 rs2074903 chr16:89811663 T/C cg19635926 chr16:89946313 TCF25 0.66 5.97 0.31 6.1e-9 Skin colour saturation; CRC cis rs7786808 0.552 rs2878456 chr7:158182129 A/T cg15440763 chr7:158190612 PTPRN2 0.53 8.42 0.42 1.14e-15 Obesity-related traits; CRC cis rs7772486 0.686 rs857883 chr6:145969214 G/T cg13319975 chr6:146136371 FBXO30 0.45 6.75 0.35 6.77e-11 Lobe attachment (rater-scored or self-reported); CRC cis rs11229555 0.645 rs7116847 chr11:58178478 C/A cg15696309 chr11:58395628 NA -0.81 -10.45 -0.5 2.9e-22 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; CRC cis rs7618915 0.547 rs11720432 chr3:52672742 T/C cg10802521 chr3:52805072 NEK4 -0.58 -8.85 -0.44 5.39e-17 Bipolar disorder; CRC cis rs12200560 0.505 rs59296768 chr6:97075535 C/T cg06623918 chr6:96969491 KIAA0776 0.52 7.76 0.39 1.08e-13 Coronary heart disease; CRC cis rs951366 0.528 rs1172198 chr1:205662718 C/T cg14159672 chr1:205819179 PM20D1 0.65 8.91 0.44 3.55e-17 Menarche (age at onset); CRC cis rs11252926 0.507 rs4881199 chr10:428090 C/G cg18196295 chr10:418757 DIP2C 0.52 8.3 0.42 2.66e-15 Psychosis in Alzheimer's disease; CRC cis rs2952156 0.920 rs2941506 chr17:37833035 A/G cg00129232 chr17:37814104 STARD3 -0.67 -11.66 -0.54 1.52e-26 Asthma; CRC cis rs11677370 0.561 rs4849990 chr2:3819558 A/G cg17052675 chr2:3827356 NA -0.65 -10.84 -0.51 1.31e-23 Type 2 diabetes; CRC cis rs3764400 0.508 rs55696440 chr17:46271146 G/A cg10706073 chr17:46328419 SKAP1 -0.64 -6.83 -0.35 4.21e-11 Body mass index; CRC cis rs798554 0.721 rs2527680 chr7:2892361 C/T cg19346786 chr7:2764209 NA -0.42 -7.0 -0.36 1.47e-11 Height; CRC cis rs4713118 0.513 rs183244 chr6:28031838 C/A cg03623178 chr6:28175578 NA 0.79 11.55 0.54 3.91e-26 Parkinson's disease; CRC cis rs9517320 1.000 rs9584856 chr13:99126551 G/T cg20487152 chr13:99095054 FARP1 0.35 5.93 0.31 7.59e-9 Longevity; CRC trans rs2303319 0.504 rs56407015 chr2:162455625 G/A cg27113153 chr11:123612418 ZNF202 -0.7 -6.15 -0.32 2.28e-9 Cognitive function; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg06884548 chr6:34856897 ANKS1A;TAF11 0.43 6.19 0.32 1.74e-9 Intelligence (multi-trait analysis); CRC cis rs2933343 1.000 rs1680784 chr3:128644458 A/G cg11901034 chr3:128598214 ACAD9 -0.52 -6.27 -0.33 1.13e-9 IgG glycosylation; CRC cis rs7224685 0.501 rs781823 chr17:3966280 G/C cg21851534 chr17:3907994 ZZEF1 0.37 6.41 0.33 5.16e-10 Type 2 diabetes; CRC cis rs1555322 0.530 rs7004 chr20:33866753 G/C cg07134254 chr20:33865797 NA 0.45 5.73 0.3 2.32e-8 Attention deficit hyperactivity disorder; CRC cis rs12681287 0.547 rs13267858 chr8:87510871 G/A cg27223183 chr8:87520930 FAM82B -0.52 -7.41 -0.38 1.05e-12 Caudate activity during reward; CRC cis rs739401 0.611 rs12284275 chr11:3024384 T/C cg25174290 chr11:3078921 CARS 0.48 7.39 0.38 1.26e-12 Longevity; CRC cis rs12760731 0.720 rs12022185 chr1:178279653 A/G cg00404053 chr1:178313656 RASAL2 1.13 11.48 0.53 6.77e-26 Obesity-related traits; CRC cis rs7640424 0.754 rs182736 chr3:107838891 C/A cg09227934 chr3:107805635 CD47 0.44 6.53 0.34 2.44e-10 Body mass index; CRC cis rs9611519 0.929 rs9611509 chr22:41565827 A/G cg06634786 chr22:41940651 POLR3H -0.47 -6.13 -0.32 2.44e-9 Neuroticism; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg05798107 chr17:40761563 FAM134C;TUBG1 0.46 6.89 0.36 2.84e-11 Intelligence (multi-trait analysis); CRC cis rs68170813 0.559 rs1018946 chr7:106851754 T/C cg02696742 chr7:106810147 HBP1 -0.6 -6.58 -0.34 1.83e-10 Coronary artery disease; CRC cis rs11792861 0.589 rs2176692 chr9:111927723 G/A cg05043794 chr9:111880884 C9orf5 -0.35 -6.49 -0.34 3.25e-10 Menarche (age at onset); CRC cis rs9400239 0.622 rs1268164 chr6:109008416 C/T cg11073813 chr6:109029018 NA 0.4 6.44 0.33 4.23e-10 Waist circumference;Body mass index;BMI (adjusted for smoking behaviour); CRC cis rs4819052 0.724 rs9753987 chr21:46661389 C/T cg19498844 chr21:46707878 POFUT2;LOC642852 0.77 10.99 0.52 3.97e-24 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs8070740 0.898 rs9896735 chr17:5325808 G/T cg25236894 chr17:5323110 RPAIN;NUP88 -0.43 -6.85 -0.35 3.54e-11 Menopause (age at onset); CRC cis rs10905065 0.965 rs2890365 chr10:5773876 C/A cg11519256 chr10:5708881 ASB13 -0.5 -7.48 -0.38 6.68e-13 Menopause (age at onset); CRC trans rs6819266 0.636 rs13148734 chr4:63330858 A/G cg12564526 chr7:66767603 PMS2L4;STAG3L4 0.38 6.08 0.32 3.28e-9 Age-related macular degeneration; CRC trans rs459571 0.959 rs2520100 chr9:136918137 A/T cg15028160 chr19:49622717 PPFIA3;C19orf73 -0.55 -6.94 -0.36 2.05e-11 Platelet distribution width; CRC cis rs4728302 0.869 rs6955707 chr7:133612188 G/A cg03336402 chr7:133662267 EXOC4 -0.43 -6.3 -0.33 9.56e-10 Intelligence;Intelligence (multi-trait analysis); CRC cis rs7539542 0.556 rs10753928 chr1:202891045 A/C cg19681188 chr1:202830198 LOC148709 -0.43 -6.31 -0.33 9.14e-10 Mean platelet volume; CRC cis rs523516 0.645 rs520054 chr17:37321538 G/A cg20555674 chr17:37321631 ARL5C 0.39 7.98 0.4 2.44e-14 IgG glycosylation; CRC cis rs2252790 0.548 rs114094955 chr6:116521164 G/T cg26893134 chr6:116381904 FRK 0.25 5.74 0.3 2.16e-8 Fast beta electroencephalogram; CRC cis rs780096 0.506 rs2288155 chr2:27714526 T/C cg12648201 chr2:27665141 KRTCAP3 -0.32 -6.09 -0.32 3.23e-9 Total body bone mineral density; CRC cis rs11645898 0.935 rs11641721 chr16:72155241 G/A cg14768367 chr16:72042858 DHODH -0.58 -6.54 -0.34 2.39e-10 Blood protein levels; CRC cis rs853679 0.517 rs4713135 chr6:28039586 G/A cg02683197 chr6:28174875 NA 0.78 9.5 0.46 4.55e-19 Depression; CRC cis rs6938 0.575 rs12902515 chr15:75160998 G/C cg17294928 chr15:75287854 SCAMP5 0.5 7.69 0.39 1.76e-13 Breast cancer; CRC cis rs2243480 1.000 rs78803505 chr7:65382572 A/T cg18252515 chr7:66147081 NA -1.08 -12.66 -0.57 3.44e-30 Diabetic kidney disease; CRC cis rs35110281 0.712 rs162345 chr21:44954155 T/G cg04455712 chr21:45112962 RRP1B 0.41 7.83 0.4 6.79e-14 Mean corpuscular volume; CRC cis rs7659604 0.846 rs60340409 chr4:122666355 G/C cg06713675 chr4:122721982 EXOSC9 -0.4 -6.49 -0.34 3.2e-10 Type 2 diabetes; CRC trans rs2797160 1.000 rs61299898 chr6:126007651 G/C cg05039488 chr6:79577232 IRAK1BP1 0.49 7.3 0.37 2.11e-12 Endometrial cancer; CRC cis rs9768139 0.733 rs34173461 chr7:158122175 C/G cg23298862 chr7:158159286 PTPRN2 0.38 5.92 0.31 7.95e-9 Calcium levels; CRC cis rs9611565 0.659 rs1810460 chr22:41927700 C/T cg03806693 chr22:41940476 POLR3H -1.11 -14.93 -0.64 7.75e-39 Vitiligo; CRC cis rs6860806 0.661 rs6871350 chr5:131580220 A/G cg18758796 chr5:131593413 PDLIM4 0.44 8.09 0.41 1.19e-14 Breast cancer; CRC cis rs727505 1.000 rs67084428 chr7:124499388 G/T cg23710748 chr7:124431027 NA -0.8 -14.18 -0.62 6.24e-36 Lewy body disease; CRC cis rs853679 0.546 rs175597 chr6:27810626 T/C cg15845792 chr6:28175446 NA 0.72 6.19 0.32 1.8e-9 Depression; CRC cis rs11626933 0.885 rs28517514 chr14:90788709 G/A cg14092571 chr14:90743983 NA -0.74 -12.26 -0.56 1.05e-28 Gut microbiota (bacterial taxa); CRC cis rs4862750 0.624 rs34414639 chr4:187873417 C/A cg10295955 chr4:187884368 NA -0.98 -21.93 -0.77 2.58e-66 Lobe attachment (rater-scored or self-reported); CRC trans rs2303319 0.504 rs961421 chr2:162626099 G/C cg20024234 chr21:43431083 ZNF295 -0.66 -5.96 -0.31 6.5e-9 Cognitive function; CRC cis rs1799949 1.000 rs4793192 chr17:41204390 T/C cg05368731 chr17:41323189 NBR1 0.68 10.3 0.49 9.6e-22 Menopause (age at onset); CRC cis rs9747201 1.000 rs3922470 chr17:80110159 C/T cg14673194 chr17:80132900 CCDC57 0.49 6.35 0.33 7.1e-10 Peripheral arterial disease (traffic-related air pollution interaction); CRC trans rs1997103 1.000 rs12532070 chr7:55407698 A/G cg20935933 chr6:143382018 AIG1 0.51 6.65 0.34 1.25e-10 QRS interval (sulfonylurea treatment interaction); CRC cis rs7909074 0.898 rs10793565 chr10:45388231 G/C cg04218760 chr10:45406644 TMEM72 -0.34 -9.79 -0.48 4.92e-20 Mean corpuscular volume; CRC cis rs7224685 0.501 rs781847 chr17:3958194 G/A cg21851534 chr17:3907994 ZZEF1 0.38 6.49 0.34 3.19e-10 Type 2 diabetes; CRC cis rs7727544 0.642 rs7705189 chr5:131623358 C/T cg12564285 chr5:131593104 PDLIM4 -0.36 -6.67 -0.35 1.09e-10 Blood metabolite levels; CRC cis rs1008375 0.966 rs10489036 chr4:17697687 A/G cg16339924 chr4:17578868 LAP3 0.47 6.02 0.32 4.56e-9 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs2882667 0.898 rs2116789 chr5:138394262 G/T cg04439458 chr5:138467593 SIL1 -0.33 -6.11 -0.32 2.77e-9 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs9733 0.596 rs11807058 chr1:150640475 G/A cg15448220 chr1:150897856 SETDB1 0.45 6.43 0.33 4.42e-10 Tonsillectomy; CRC cis rs9649213 0.593 rs6948540 chr7:97960066 A/G cg08684580 chr7:98029266 BAIAP2L1 -0.31 -5.62 -0.3 4.05e-8 Prostate cancer (SNP x SNP interaction); CRC cis rs3796619 1.000 rs4045481 chr4:1090625 C/T cg11579758 chr4:1086637 RNF212 0.42 6.96 0.36 1.9e-11 Recombination rate (males); CRC cis rs1552244 0.554 rs6762594 chr3:9995516 G/A cg16606324 chr3:10149918 C3orf24 0.45 6.82 0.35 4.25e-11 Alzheimer's disease; CRC cis rs853679 0.517 rs17711344 chr6:28077602 A/G cg03623178 chr6:28175578 NA -0.96 -12.59 -0.57 5.92e-30 Depression; CRC trans rs7267979 0.932 rs367666 chr20:25449818 T/C cg17903999 chr18:56338584 MALT1 -0.42 -7.02 -0.36 1.3e-11 Liver enzyme levels (alkaline phosphatase); CRC cis rs642803 0.551 rs1308020 chr11:65497558 G/A cg27068330 chr11:65405492 SIPA1 0.44 5.79 0.3 1.63e-8 Urate levels; CRC cis rs892085 0.681 rs7246673 chr19:10876841 T/G cg17710535 chr19:10819994 QTRT1 0.38 5.86 0.31 1.11e-8 Psoriasis vulgaris;Psoriasis; CRC cis rs4566357 0.557 rs2272201 chr2:227912551 T/A cg11843606 chr2:227700838 RHBDD1 -0.44 -6.79 -0.35 5.1e-11 Coronary artery disease; CRC cis rs4665809 0.590 rs62128455 chr2:26466530 G/A cg27170947 chr2:26402098 FAM59B 0.59 7.71 0.39 1.53e-13 Gut microbiome composition (summer); CRC trans rs7613875 0.620 rs34312088 chr3:50032133 C/T cg21665057 chr3:196295764 WDR53;FBXO45 0.44 6.35 0.33 6.99e-10 Body mass index; CRC cis rs290268 0.838 rs290989 chr9:93561836 T/C cg02608019 chr9:93564028 SYK 0.46 7.24 0.37 3.27e-12 Platelet count; CRC cis rs72634258 0.554 rs12745962 chr1:7919825 C/T cg26816564 chr1:7831052 VAMP3 0.75 8.73 0.43 1.31e-16 Inflammatory bowel disease; CRC cis rs1943345 0.556 rs528703 chr11:82926035 G/A cg07047830 chr11:82868014 PCF11 0.45 6.42 0.33 4.74e-10 Obesity-related traits; CRC cis rs12936587 0.535 rs6502615 chr17:17612023 C/T cg09796270 chr17:17721594 SREBF1 -0.4 -6.41 -0.33 5.18e-10 Hip circumference;Coronary artery disease or large artery stroke;Coronary heart disease;Coronary artery disease; CRC cis rs709400 1.000 rs10135248 chr14:104122310 T/C cg12935359 chr14:103987150 CKB -0.36 -6.02 -0.31 4.75e-9 Body mass index; CRC cis rs7493 0.755 rs116306774 chr7:95016976 G/A cg21856205 chr7:94953877 PON1 -0.47 -5.99 -0.31 5.45e-9 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs597539 0.652 rs646586 chr11:68681653 C/T cg06112835 chr11:68658793 MRPL21 -0.39 -6.27 -0.33 1.15e-9 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs561341 0.714 rs547473 chr17:30297560 T/G cg23018236 chr17:30244563 NA -0.57 -7.48 -0.38 6.78e-13 Hip circumference adjusted for BMI; CRC cis rs12476592 0.602 rs7608470 chr2:63691478 T/C cg10828910 chr2:63850056 LOC388955 0.46 5.64 0.3 3.64e-8 Childhood ear infection; CRC cis rs78707713 0.560 rs2394563 chr10:71238618 G/A cg12610070 chr10:71211762 TSPAN15 -0.43 -7.51 -0.38 5.75e-13 Venous thromboembolism; CRC trans rs12048904 0.504 rs12039319 chr1:101340134 C/T cg01303055 chr11:11265429 NA -0.36 -6.0 -0.31 5.21e-9 Multiple sclerosis; CRC cis rs2836974 0.932 rs8128734 chr21:40569511 G/A cg11644478 chr21:40555479 PSMG1 0.81 12.33 0.56 5.83e-29 Cognitive function; CRC cis rs7781557 1.000 rs12113073 chr7:102482527 T/C cg18108683 chr7:102477205 FBXL13 -0.57 -7.22 -0.37 3.61e-12 Colorectal adenoma (advanced); CRC cis rs6585424 0.850 rs75804987 chr10:81932509 C/T cg11900509 chr10:81946545 ANXA11 -0.76 -9.32 -0.46 1.78e-18 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs10256972 0.577 rs2949179 chr7:1209885 C/G cg03188948 chr7:1209495 NA 0.6 9.13 0.45 7.26e-18 Longevity;Endometriosis; CRC cis rs7493 1.000 rs3779492 chr7:95044183 C/T cg17330251 chr7:94953956 PON1 -0.56 -7.25 -0.37 3.02e-12 Yu-Zhi constitution type in type 2 diabetes; CRC trans rs149866169 1 rs149866169 chr6:27441723 T/A cg06606381 chr12:133084897 FBRSL1 -0.88 -7.08 -0.36 8.82e-12 Neuroticism (multi-trait analysis);Lung cancer in ever smokers;Subjective well-being (multi-trait analysis);Lung cancer;Squamous cell lung carcinoma; CRC cis rs7618915 0.547 rs12486847 chr3:52691112 T/C cg08222913 chr3:52553049 STAB1 -0.34 -6.12 -0.32 2.7e-9 Bipolar disorder; CRC cis rs1048238 0.846 rs945420 chr1:16345208 G/A cg22431228 chr1:16359049 CLCNKA -0.43 -8.33 -0.42 2.18e-15 Systolic blood pressure; CRC cis rs7824557 0.564 rs2736288 chr8:11228100 G/A cg08071915 chr8:12219732 FAM66A 0.33 6.03 0.32 4.3e-9 Retinal vascular caliber; CRC cis rs11098499 0.739 rs4833612 chr4:120147596 A/C cg24375607 chr4:120327624 NA -0.46 -7.73 -0.39 1.31e-13 Corneal astigmatism; CRC cis rs9311474 0.713 rs352170 chr3:52236077 A/G cg08222913 chr3:52553049 STAB1 -0.35 -6.53 -0.34 2.49e-10 Electroencephalogram traits; CRC trans rs6472235 0.837 rs11997658 chr8:66920756 C/T cg07884673 chr3:53033167 SFMBT1 -0.45 -6.07 -0.32 3.54e-9 Myopia (pathological);Plateletcrit; CRC cis rs11645898 0.574 rs17604349 chr16:72210865 C/T cg14768367 chr16:72042858 DHODH -0.52 -6.15 -0.32 2.23e-9 Blood protein levels; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg22081084 chr1:89990230 LRRC8B 0.49 6.61 0.34 1.58e-10 Thyroid stimulating hormone; CRC cis rs1008375 1.000 rs1006722 chr4:17618713 A/G cg16339924 chr4:17578868 LAP3 -0.52 -6.81 -0.35 4.76e-11 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs2120019 1.000 rs12903201 chr15:75370776 A/C cg09165964 chr15:75287851 SCAMP5 -0.8 -12.62 -0.57 4.92e-30 Blood trace element (Zn levels); CRC cis rs807669 0.903 rs1771540 chr22:19173933 T/A cg02655711 chr22:19163373 SLC25A1 0.98 20.12 0.74 2.92e-59 Metabolite levels; CRC cis rs6089584 0.706 rs6089625 chr20:60620622 T/C cg23262073 chr20:60523788 NA -0.45 -6.99 -0.36 1.52e-11 Body mass index; CRC cis rs875971 0.862 rs28491091 chr7:65669064 G/T cg00343986 chr7:65444356 GUSB -0.47 -6.52 -0.34 2.69e-10 Aortic root size; CRC trans rs1602565 1.000 rs1907605 chr11:29158507 A/G cg10961700 chr1:150898620 SETDB1 -0.59 -6.07 -0.32 3.61e-9 Schizophrenia; CRC cis rs9911578 0.835 rs58647683 chr17:56483194 T/C cg12560992 chr17:57184187 TRIM37 -0.82 -14.08 -0.61 1.44e-35 Intelligence (multi-trait analysis); CRC cis rs1552244 0.572 rs2054478 chr3:10172211 C/T cg02579736 chr3:10068473 FANCD2;CIDECP 1.04 11.89 0.55 2.36e-27 Alzheimer's disease; CRC cis rs8040855 0.644 rs2342120 chr15:85728820 G/T cg10818794 chr15:86012489 AKAP13 0.41 6.4 0.33 5.3e-10 Bulimia nervosa; CRC cis rs1707322 0.721 rs4559551 chr1:46167533 T/C cg06784218 chr1:46089804 CCDC17 0.66 12.43 0.57 2.44e-29 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs908922 0.676 rs10888494 chr1:152514709 T/C cg09873164 chr1:152488093 CRCT1 0.39 6.58 0.34 1.84e-10 Hair morphology; CRC cis rs7666738 0.830 rs7694889 chr4:98855596 T/C cg05340658 chr4:99064831 C4orf37 0.57 8.45 0.42 9.23e-16 Colonoscopy-negative controls vs population controls; CRC cis rs2262909 0.962 rs401424 chr19:22232023 A/G cg11619707 chr19:22235551 ZNF257 -0.28 -5.82 -0.31 1.36e-8 Chagas cardiomyopathy in Tripanosoma cruzi seropositivity; CRC cis rs8062405 0.964 rs11864107 chr16:28885931 T/C cg16576597 chr16:28551801 NUPR1 0.48 6.82 0.35 4.39e-11 Cognitive ability (multi-trait analysis);Cognitive ability; CRC cis rs6952808 0.862 rs4721167 chr7:1933224 C/T cg04267008 chr7:1944627 MAD1L1 -0.83 -12.77 -0.58 1.27e-30 Bipolar disorder and schizophrenia; CRC trans rs1814175 0.817 rs10839401 chr11:49876144 C/T cg11707556 chr5:10655725 ANKRD33B -0.42 -8.05 -0.41 1.48e-14 Height; CRC cis rs875971 0.545 rs66594357 chr7:65792784 G/A cg05627663 chr7:65219948 SNORA22;CCT6P1 0.56 7.38 0.38 1.31e-12 Aortic root size; CRC cis rs1862618 0.853 rs861283 chr5:56184610 C/T cg24531977 chr5:56204891 C5orf35 -0.84 -10.92 -0.52 6.54e-24 Initial pursuit acceleration; CRC cis rs7829975 0.846 rs7005216 chr8:8547110 C/G cg06636001 chr8:8085503 FLJ10661 -0.56 -9.0 -0.44 1.88e-17 Mood instability; CRC cis rs10256972 0.621 rs2280725 chr7:1087426 G/T cg22907277 chr7:1156413 C7orf50 0.47 7.01 0.36 1.32e-11 Longevity;Endometriosis; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg25552655 chr19:33864476 CEBPG 0.5 6.97 0.36 1.75e-11 Anxiety disorder; CRC cis rs7552404 0.731 rs11161857 chr1:76370228 G/C cg10523679 chr1:76189770 ACADM 0.74 8.89 0.44 4.07e-17 Blood metabolite levels;Acylcarnitine levels; CRC cis rs2836974 0.568 rs2183573 chr21:40574305 A/G cg06238570 chr21:40685208 BRWD1 -0.8 -12.82 -0.58 8.45e-31 Cognitive function; CRC cis rs9807989 0.839 rs9308857 chr2:102979624 G/A cg03938978 chr2:103052716 IL18RAP 0.37 6.1 0.32 3.01e-9 Asthma; CRC cis rs875971 1.000 rs6460292 chr7:65810075 G/A cg18912574 chr7:65842487 NCRNA00174 -0.36 -6.23 -0.32 1.44e-9 Aortic root size; CRC cis rs1552244 1.000 rs17032299 chr3:10087638 C/T cg08888203 chr3:10149979 C3orf24 0.73 10.41 0.5 3.88e-22 Alzheimer's disease; CRC cis rs875971 0.862 rs2024192 chr7:66041447 G/T cg18252515 chr7:66147081 NA 0.43 6.18 0.32 1.9e-9 Aortic root size; CRC trans rs10982213 0.830 rs2274163 chr9:117188714 C/T cg21866596 chr11:93474724 C11orf54;TAF1D 0.39 6.07 0.32 3.49e-9 Interleukin-6 levels; CRC cis rs56307353 0.753 rs62129495 chr19:1962789 T/C cg08800497 chr19:1970008 CSNK1G2 0.57 8.96 0.44 2.53e-17 Coronary artery disease; CRC cis rs1008375 1.000 rs4698200 chr4:17657051 G/A cg02297831 chr4:17616191 MED28 0.43 5.7 0.3 2.73e-8 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs7412746 0.611 rs12085336 chr1:150775780 A/T cg18016565 chr1:150552671 MCL1 0.42 6.0 0.31 5.18e-9 Melanoma; CRC cis rs853679 0.517 rs9295761 chr6:28147987 A/G cg25164649 chr6:28176230 NA 0.8 9.96 0.48 1.34e-20 Depression; CRC cis rs7945705 0.782 rs2742545 chr11:8884308 C/G cg21881798 chr11:8931708 C11orf17;ST5 -0.73 -12.88 -0.58 5.02e-31 Hemoglobin concentration; CRC trans rs3733585 0.699 rs1079128 chr4:9951221 T/C cg26043149 chr18:55253948 FECH -0.46 -6.94 -0.36 2.07e-11 Cleft plate (environmental tobacco smoke interaction); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg16944820 chr13:45492071 NA 0.41 6.17 0.32 1.97e-9 Intelligence (multi-trait analysis); CRC cis rs17401966 0.931 rs912961 chr1:10356848 A/G cg19773385 chr1:10388646 KIF1B -0.7 -11.46 -0.53 8.13e-26 Hepatocellular carcinoma; CRC cis rs9486715 0.758 rs9386528 chr6:96928514 G/A cg18709589 chr6:96969512 KIAA0776 -0.5 -6.86 -0.35 3.4e-11 Headache; CRC trans rs1325195 0.507 rs10798652 chr1:179061427 A/G cg11624085 chr17:8464688 MYH10 0.41 6.18 0.32 1.92e-9 IgE grass sensitization; CRC trans rs9409565 0.826 rs9409556 chr9:97239268 T/C cg05679027 chr9:99775184 HIATL2 -0.4 -6.05 -0.32 3.91e-9 Colorectal cancer (alcohol consumption interaction); CRC cis rs10911232 0.507 rs4642853 chr1:182996242 C/T ch.1.3577855R chr1:183094577 LAMC1 0.87 15.19 0.64 7.56e-40 Hypertriglyceridemia; CRC cis rs875971 0.862 rs6460279 chr7:65662761 T/C cg18876405 chr7:65276391 NA -0.54 -8.74 -0.43 1.21e-16 Aortic root size; CRC cis rs11098499 0.866 rs13125526 chr4:120288019 G/A cg09307838 chr4:120376055 NA 0.68 10.53 0.5 1.51e-22 Corneal astigmatism; CRC cis rs2727020 0.619 rs11040300 chr11:49269984 C/A cg27395922 chr11:50257633 LOC441601 0.35 5.71 0.3 2.58e-8 Coronary artery disease; CRC cis rs6088590 1.000 rs6088595 chr20:33358499 T/A cg08999081 chr20:33150536 PIGU 0.49 7.61 0.39 2.99e-13 Coronary artery disease; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg11744777 chr6:27799370 HIST1H4K 0.47 7.24 0.37 3.28e-12 Liver disease severity in Alagille syndrome; CRC cis rs7208859 0.725 rs7342938 chr17:29189830 A/G cg13385521 chr17:29058706 SUZ12P 0.55 7.36 0.38 1.53e-12 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs9814567 1.000 rs35718987 chr3:134272783 C/T cg06109529 chr3:134205091 CEP63;ANAPC13 0.82 12.06 0.55 5.69e-28 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs826838 0.802 rs10785619 chr12:38742897 T/A cg13010199 chr12:38710504 ALG10B 0.48 6.92 0.36 2.36e-11 Heart rate; CRC cis rs61008539 0.893 rs4719460 chr7:859610 C/T cg15782153 chr7:917662 C7orf20 -0.48 -7.82 -0.4 7.46e-14 Perceived unattractiveness to mosquitoes; CRC cis rs1865760 1.000 rs9467636 chr6:25919549 A/C cg17691542 chr6:26056736 HIST1H1C 0.56 8.43 0.42 1.08e-15 Height; CRC cis rs9322193 0.923 rs9766004 chr6:150075499 C/T cg13206674 chr6:150067644 NUP43 0.65 9.92 0.48 1.84e-20 Lung cancer; CRC cis rs4727027 0.866 rs12666477 chr7:148812322 A/G cg23583168 chr7:148888333 NA -0.83 -13.36 -0.59 8.28e-33 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC trans rs6561151 0.681 rs17653353 chr13:44421746 A/G cg17145862 chr1:211918768 LPGAT1 0.49 6.31 0.33 8.95e-10 Crohn's disease; CRC cis rs2952156 0.684 rs931992 chr17:37821435 G/T cg15445000 chr17:37608096 MED1 0.27 5.98 0.31 5.91e-9 Asthma; CRC cis rs10256972 0.616 rs4585652 chr7:1145396 A/G cg18765753 chr7:1198926 ZFAND2A -0.36 -6.05 -0.32 3.84e-9 Longevity;Endometriosis; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg26084319 chr14:21905280 CHD8 0.47 6.17 0.32 2.02e-9 Thyroid stimulating hormone; CRC cis rs73206853 0.764 rs55887805 chr12:110597246 T/C cg12870014 chr12:110450643 ANKRD13A 0.83 10.65 0.51 5.74e-23 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC cis rs67478160 0.643 rs1535098 chr14:104216513 T/A cg08213375 chr14:104286397 PPP1R13B 0.65 13.79 0.61 1.92e-34 Schizophrenia; CRC cis rs6502050 0.835 rs7502676 chr17:80093433 C/G cg13198984 chr17:80129470 CCDC57 0.43 7.68 0.39 1.89e-13 Life satisfaction; CRC cis rs17401966 0.838 rs12125535 chr1:10350849 T/A cg19773385 chr1:10388646 KIF1B -0.67 -11.02 -0.52 3.09e-24 Hepatocellular carcinoma; CRC cis rs7666738 0.791 rs7660866 chr4:98961335 G/A cg17366294 chr4:99064904 C4orf37 0.43 7.36 0.38 1.49e-12 Colonoscopy-negative controls vs population controls; CRC cis rs6502050 0.835 rs34620191 chr17:80149532 G/A cg02741985 chr17:80059408 CCDC57 0.44 7.18 0.37 4.6e-12 Life satisfaction; CRC trans rs2243480 1.000 rs316327 chr7:65609201 G/T cg10756647 chr7:56101905 PSPH -0.75 -8.14 -0.41 8.07e-15 Diabetic kidney disease; CRC cis rs2976388 1.000 rs1045574 chr8:143763958 C/T cg05569086 chr8:143859399 LYNX1 -0.32 -5.63 -0.3 3.93e-8 Urinary tract infection frequency; CRC cis rs875971 0.862 rs709596 chr7:65825913 A/G cg18252515 chr7:66147081 NA -0.38 -5.63 -0.3 3.94e-8 Aortic root size; CRC cis rs1847505 0.609 rs9539004 chr13:61587049 T/C cg14094164 chr13:61491000 NA 0.31 5.94 0.31 7.19e-9 Polychlorinated biphenyl levels; CRC cis rs6951245 0.872 rs75398423 chr7:1098414 T/G cg03188948 chr7:1209495 NA 0.65 6.84 0.35 3.8e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs4919087 1.000 rs11189122 chr10:99072595 G/A cg25902810 chr10:99078978 FRAT1 0.39 5.98 0.31 5.67e-9 Monocyte count; CRC cis rs6860806 0.507 rs273901 chr5:131694360 G/T cg27615366 chr5:131592974 PDLIM4 0.33 5.78 0.3 1.7e-8 Breast cancer; CRC cis rs57221529 0.766 rs56216231 chr5:581193 G/A cg14541582 chr5:601475 NA -0.37 -7.19 -0.37 4.49e-12 Lung disease severity in cystic fibrosis; CRC trans rs916888 0.610 rs199452 chr17:44801340 C/T cg22433210 chr17:43662623 NA 0.61 7.75 0.39 1.13e-13 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC trans rs9326248 1.000 rs585849 chr11:117069061 A/G cg18755114 chr2:209119030 IDH1 -0.4 -6.17 -0.32 2.05e-9 Blood protein levels; CRC cis rs6500602 0.701 rs11643057 chr16:4544505 C/T cg14951292 chr16:4525986 HMOX2;NMRAL1 0.57 8.38 0.42 1.58e-15 Schizophrenia; CRC cis rs35995292 0.500 rs2392606 chr7:38926955 C/A cg19327137 chr7:38886074 VPS41 0.62 10.13 0.49 3.53e-21 Subjective well-being (multi-trait analysis); CRC cis rs34779708 0.966 rs17591781 chr10:35498538 G/A cg03585969 chr10:35415529 CREM 0.55 7.4 0.38 1.17e-12 Inflammatory bowel disease;Crohn's disease; CRC cis rs1552244 1.000 rs6442150 chr3:10122575 T/C cg13047869 chr3:10149882 C3orf24 0.57 7.8 0.4 8.27e-14 Alzheimer's disease; CRC cis rs1862618 0.573 rs2591962 chr5:56237155 G/A cg03609598 chr5:56110824 MAP3K1 0.75 8.73 0.43 1.31e-16 Initial pursuit acceleration; CRC cis rs10883723 0.810 rs6584508 chr10:104258567 A/G cg04362960 chr10:104952993 NT5C2 -0.43 -6.11 -0.32 2.8e-9 Allergic disease (asthma, hay fever or eczema); CRC cis rs7666738 0.830 rs1869897 chr4:98730997 C/T cg05340658 chr4:99064831 C4orf37 0.54 8.0 0.4 2.21e-14 Colonoscopy-negative controls vs population controls; CRC cis rs4654899 0.609 rs12128470 chr1:21534055 T/C cg02927042 chr1:21476669 EIF4G3 -0.46 -7.16 -0.37 5.25e-12 Superior frontal gyrus grey matter volume; CRC cis rs9419702 0.639 rs9419624 chr10:133534822 G/A cg04492858 chr10:133558786 NA 0.35 5.62 0.3 4.12e-8 Survival in rectal cancer; CRC cis rs883565 0.655 rs6778963 chr3:39091812 T/G cg01426195 chr3:39028469 NA -0.54 -8.77 -0.44 9.85e-17 Handedness; CRC cis rs9926296 0.529 rs7195906 chr16:89806347 A/T cg04287289 chr16:89883240 FANCA 0.79 14.03 0.61 2.24e-35 Vitiligo; CRC cis rs10504229 0.815 rs55855654 chr8:58164299 T/G cg22535103 chr8:58192502 C8orf71 -0.73 -8.63 -0.43 2.64e-16 Developmental language disorder (linguistic errors); CRC cis rs1448094 0.512 rs7313035 chr12:86250100 C/G cg02569458 chr12:86230093 RASSF9 0.43 7.41 0.38 1.06e-12 Major depressive disorder; CRC cis rs10870270 0.912 rs7079991 chr10:133736130 A/G cg08754478 chr10:133766260 PPP2R2D -0.65 -9.43 -0.46 7.78e-19 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; CRC cis rs6499255 0.638 rs57824734 chr16:69811995 C/T cg04110750 chr16:69646130 NFAT5 -0.46 -6.21 -0.32 1.57e-9 IgE levels; CRC cis rs6952808 0.782 rs4236271 chr7:1881369 C/T cg22963979 chr7:1858916 MAD1L1 -0.54 -8.68 -0.43 1.91e-16 Bipolar disorder and schizophrenia; CRC trans rs61931739 0.500 rs9919726 chr12:34510783 A/G cg13010199 chr12:38710504 ALG10B 0.45 6.51 0.34 2.88e-10 Morning vs. evening chronotype; CRC cis rs4332037 0.539 rs11762545 chr7:2060775 C/T cg23422044 chr7:1970798 MAD1L1 -0.55 -6.68 -0.35 1.04e-10 Bipolar disorder; CRC cis rs921968 0.541 rs7574429 chr2:219498759 T/G cg02176678 chr2:219576539 TTLL4 0.57 8.92 0.44 3.29e-17 Mean corpuscular hemoglobin concentration; CRC cis rs12291225 0.679 rs1043237 chr11:14289053 A/T cg05501817 chr11:14380813 RRAS2 -0.45 -5.96 -0.31 6.67e-9 Sense of smell; CRC cis rs3204270 0.684 rs62080212 chr17:79642500 G/A cg09655341 chr17:79618100 PDE6G 0.58 6.92 0.36 2.44e-11 Dental caries; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg06643102 chr19:8455567 RAB11B 0.46 7.51 0.38 5.72e-13 Liver disease severity in Alagille syndrome; CRC trans rs4942242 0.640 rs9533563 chr13:44212127 A/G cg26741380 chr15:41871084 TYRO3 -0.48 -6.75 -0.35 6.5500000000000006e-11 Response to tocilizumab in rheumatoid arthritis; CRC cis rs2075371 0.933 rs1868784 chr7:133945932 A/G cg11752832 chr7:134001865 SLC35B4 0.42 6.35 0.33 6.97e-10 Mean platelet volume; CRC cis rs875971 0.638 rs7793569 chr7:66116633 T/G cg11764359 chr7:65958608 NA -0.54 -8.3 -0.42 2.71e-15 Aortic root size; CRC cis rs8177253 0.829 rs6794945 chr3:133518463 A/G cg08048268 chr3:133502702 NA 0.4 7.16 0.37 5.37e-12 Iron status biomarkers; CRC cis rs12479064 0.604 rs11893359 chr2:99954608 A/G cg14399236 chr2:99771627 LIPT1;TSGA10 -0.63 -7.84 -0.4 6.15e-14 Chronic sinus infection; CRC cis rs1670533 1.000 rs4690215 chr4:1054619 G/C cg27284194 chr4:1044797 NA 0.5 6.2 0.32 1.66e-9 Recombination rate (females); CRC cis rs10504229 1.000 rs61212428 chr8:58173963 G/A cg02290350 chr8:58132656 NA -0.42 -5.96 -0.31 6.62e-9 Developmental language disorder (linguistic errors); CRC cis rs9487051 0.872 rs9400269 chr6:109606065 C/G cg12927641 chr6:109611667 NA -0.37 -6.75 -0.35 6.71e-11 Reticulocyte fraction of red cells; CRC cis rs7949030 0.626 rs11231141 chr11:62326265 T/C cg13298116 chr11:62369859 EML3;MTA2 0.62 11.01 0.52 3.36e-24 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; CRC trans rs10842750 1.000 rs10842750 chr12:26690565 G/T cg05968270 chr1:65533502 NA 0.57 6.82 0.35 4.47e-11 Kashin-Beck disease; CRC cis rs11602339 1 rs11602339 chr11:47761471 C/T cg20307385 chr11:47447363 PSMC3 -0.5 -6.64 -0.34 1.29e-10 Body mass index; CRC cis rs1152591 0.562 rs872227 chr14:64656165 T/C cg21174375 chr14:64681225 SYNE2 0.41 6.53 0.34 2.54e-10 Atrial fibrillation; CRC cis rs4862750 0.914 rs1991255 chr4:187875340 G/A cg07414643 chr4:187882934 NA 0.37 6.48 0.34 3.29e-10 Lobe attachment (rater-scored or self-reported); CRC trans rs2018683 0.711 rs2158788 chr7:28971958 G/A cg19402173 chr7:128379420 CALU -0.44 -6.32 -0.33 8.55e-10 Response to irinotecan and platinum-based chemotherapy in non-small-cell lung cancer; CRC cis rs7584330 0.554 rs3751107 chr2:238427251 G/A cg14458575 chr2:238380390 NA 0.46 6.53 0.34 2.47e-10 Prostate cancer; CRC cis rs72627123 0.867 rs113768127 chr14:74467839 T/C cg12022184 chr14:74485813 ENTPD5;C14orf45 0.71 5.92 0.31 8.3e-9 Morning vs. evening chronotype; CRC cis rs4713118 0.662 rs149969 chr6:27977737 A/G cg12273811 chr6:28175739 NA 0.61 8.68 0.43 1.89e-16 Parkinson's disease; CRC cis rs644799 1.000 rs494829 chr11:95571750 C/A cg25478527 chr11:95522999 CEP57;FAM76B 0.52 7.81 0.4 7.95e-14 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs7147624 1.000 rs7147624 chr14:65865625 G/T cg03016385 chr14:66212404 NA 0.95 10.15 0.49 3.16e-21 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs7937682 0.883 rs2212520 chr11:111462096 C/T cg19812747 chr11:111475976 SIK2 -0.57 -9.72 -0.47 8.51e-20 Primary sclerosing cholangitis; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg05137146 chr16:30103511 TBX6 0.4 6.36 0.33 6.78e-10 Liver disease severity in Alagille syndrome; CRC cis rs10193935 0.792 rs2053349 chr2:42516205 G/A cg27598129 chr2:42591480 NA -0.54 -6.7 -0.35 8.85e-11 Colonoscopy-negative controls vs population controls; CRC cis rs17067123 0.614 rs56749262 chr4:180067592 C/A cg26610307 chr4:180072759 NA -0.56 -6.74 -0.35 6.94e-11 Response to hepatitis C treatment; CRC cis rs8014204 0.762 rs10148293 chr14:75296831 C/T cg03030879 chr14:75389066 RPS6KL1 0.41 6.66 0.34 1.18e-10 Caffeine consumption; CRC cis rs2204008 0.748 rs7312204 chr12:38334909 T/C cg26384229 chr12:38710491 ALG10B 0.67 9.76 0.47 6.42e-20 Bladder cancer; CRC cis rs10189230 0.967 rs7573758 chr2:222357326 G/T cg14652038 chr2:222343519 EPHA4 0.53 10.29 0.49 1.03e-21 Urate levels in lean individuals; CRC cis rs9309473 0.583 rs6709853 chr2:73576065 T/A cg20560298 chr2:73613845 ALMS1 -0.48 -6.51 -0.34 2.76e-10 Metabolite levels; CRC cis rs7487075 0.859 rs7960147 chr12:46751454 C/T cg22049899 chr12:47219821 SLC38A4 0.32 5.88 0.31 1.03e-8 Itch intensity from mosquito bite; CRC trans rs2727020 0.796 rs7131672 chr11:49274421 A/C cg11707556 chr5:10655725 ANKRD33B 0.39 6.32 0.33 8.46e-10 Coronary artery disease; CRC trans rs875971 0.660 rs2191268 chr7:66110224 C/T cg07225547 chr2:211035530 C2orf67 -0.43 -6.54 -0.34 2.29e-10 Aortic root size; CRC cis rs7089973 0.604 rs2420067 chr10:116590348 A/G cg23260525 chr10:116636907 FAM160B1 0.35 8.07 0.41 1.34e-14 Bipolar disorder or attention deficit hyperactivity disorder; CRC cis rs4253772 0.591 rs6008546 chr22:46686377 T/G cg03482458 chr22:46692211 CN5H6.4;GTSE1 0.55 7.35 0.38 1.6e-12 LDL cholesterol;Cholesterol, total; CRC cis rs9303280 0.901 rs883770 chr17:38063381 C/T cg00129232 chr17:37814104 STARD3 -0.52 -8.33 -0.42 2.15e-15 Self-reported allergy; CRC cis rs4588572 0.644 rs10942856 chr5:77746199 A/G cg11547950 chr5:77652471 NA 0.49 7.24 0.37 3.1e-12 Triglycerides; CRC cis rs6582630 0.519 rs4002438 chr12:38484880 C/T cg26384229 chr12:38710491 ALG10B 0.72 10.11 0.49 4.19e-21 Drug-induced liver injury (flucloxacillin); CRC cis rs6952808 0.756 rs4719311 chr7:1881813 C/T cg14004847 chr7:1930337 MAD1L1 -0.44 -6.23 -0.33 1.4e-9 Bipolar disorder and schizophrenia; CRC cis rs1395 0.710 rs1992291 chr2:27504312 A/G cg23587288 chr2:27483067 SLC30A3 -0.39 -6.36 -0.33 6.58e-10 Blood metabolite levels; CRC cis rs8077889 0.956 rs17742347 chr17:41846468 A/G cg25876840 chr17:41920477 NA -0.52 -7.02 -0.36 1.24e-11 Triglycerides; CRC trans rs35110281 0.633 rs2329593 chr21:45121987 T/C cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.44 7.11 0.36 7.27e-12 Mean corpuscular volume; CRC cis rs2180341 1.000 rs6569480 chr6:127621748 A/G cg24812749 chr6:127587940 RNF146 0.94 13.59 0.6 1.08e-33 Breast cancer; CRC trans rs9467711 1.000 rs9467701 chr6:26312170 G/C cg15845792 chr6:28175446 NA 0.67 6.48 0.34 3.34e-10 Autism spectrum disorder or schizophrenia; CRC cis rs780096 0.526 rs11126999 chr2:27670307 G/A cg17158414 chr2:27665306 KRTCAP3 -0.3 -6.23 -0.32 1.42e-9 Total body bone mineral density; CRC cis rs9487051 0.646 rs11153167 chr6:109622582 A/T cg01475377 chr6:109611718 NA 0.37 5.92 0.31 8.07e-9 Reticulocyte fraction of red cells; CRC cis rs2228479 0.717 rs17233678 chr16:89809962 T/C cg06656553 chr16:89960601 TCF25 -0.68 -5.71 -0.3 2.55e-8 Skin colour saturation; CRC cis rs7474896 0.537 rs2749589 chr10:38266870 C/T cg25427524 chr10:38739819 LOC399744 0.5 6.2 0.32 1.73e-9 Obesity (extreme); CRC cis rs17001868 0.614 rs5995849 chr22:40777072 C/G cg07138101 chr22:40742427 ADSL -0.47 -6.66 -0.34 1.17e-10 Mammographic density (dense area); CRC cis rs11722228 1.000 rs6823877 chr4:9921931 T/C cg00071950 chr4:10020882 SLC2A9 -0.49 -7.29 -0.37 2.28e-12 Gout;Urate levels;Serum uric acid levels; CRC trans rs7267979 0.932 rs449370 chr20:25451180 A/G cg17903999 chr18:56338584 MALT1 0.41 6.92 0.36 2.41e-11 Liver enzyme levels (alkaline phosphatase); CRC cis rs921968 0.541 rs12617603 chr2:219369288 A/G cg02176678 chr2:219576539 TTLL4 -0.57 -9.18 -0.45 4.97e-18 Mean corpuscular hemoglobin concentration; CRC cis rs6960043 0.738 rs7798360 chr7:15055972 A/G cg19272540 chr7:15055459 NA 0.23 6.15 0.32 2.26e-9 Type 2 diabetes; CRC cis rs12580194 0.593 rs7313465 chr12:55736863 C/T cg19537932 chr12:55886519 OR6C68 -0.65 -8.42 -0.42 1.16e-15 Cancer; CRC cis rs7647973 1.000 rs6446275 chr3:49466871 A/G cg07690219 chr3:49449608 TCTA;RHOA 0.5 5.63 0.3 3.89e-8 Menarche (age at onset); CRC cis rs2120019 0.935 rs34913788 chr15:75372617 A/C cg11632617 chr15:75315747 PPCDC -0.55 -7.91 -0.4 4e-14 Blood trace element (Zn levels); CRC cis rs8031584 0.541 rs2955777 chr15:31219788 A/C cg19680485 chr15:31195859 MTMR15 0.47 6.6 0.34 1.68e-10 Huntington's disease progression; CRC cis rs2836974 0.897 rs8133146 chr21:40614298 T/C cg17971929 chr21:40555470 PSMG1 0.82 11.71 0.54 1.08e-26 Cognitive function; CRC cis rs1218582 0.772 rs2174507 chr1:154887949 C/T cg06221963 chr1:154839813 KCNN3 -0.77 -15.56 -0.65 2.56e-41 Prostate cancer; CRC cis rs10504229 1.000 rs112272435 chr8:58170371 A/G cg22535103 chr8:58192502 C8orf71 -0.82 -12.27 -0.56 9.63e-29 Developmental language disorder (linguistic errors); CRC cis rs478304 0.619 rs10896028 chr11:65432187 A/T cg27068330 chr11:65405492 SIPA1 -0.7 -10.64 -0.51 6.45e-23 Acne (severe); CRC cis rs1577917 1.000 rs6933377 chr6:86705255 C/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A 0.46 6.28 0.33 1.08e-9 Response to antipsychotic treatment; CRC cis rs4727027 0.800 rs12530946 chr7:148887942 A/G cg23583168 chr7:148888333 NA -0.91 -17.78 -0.7 5.08e-50 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC cis rs17666538 0.792 rs1703912 chr8:600643 A/G cg07234876 chr8:600039 NA 0.99 9.35 0.46 1.37e-18 IgG glycosylation; CRC cis rs6570726 0.902 rs396681 chr6:145853603 T/C cg05347473 chr6:146136440 FBXO30 0.39 6.17 0.32 2e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs6951245 0.744 rs10265758 chr7:1172518 C/T cg22907277 chr7:1156413 C7orf50 0.76 8.87 0.44 4.84e-17 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs2072499 0.966 rs2253677 chr1:156171296 C/G cg24450063 chr1:156163899 SLC25A44 -1.16 -28.76 -0.85 8.51e-92 Testicular germ cell tumor; CRC cis rs7927592 0.763 rs596494 chr11:68251054 T/G cg01657329 chr11:68192670 LRP5 -0.54 -8.95 -0.44 2.57e-17 Total body bone mineral density; CRC cis rs6540559 1.000 rs12070337 chr1:209992127 G/A cg22029157 chr1:209979665 IRF6 0.7 9.73 0.47 8.02e-20 Cleft lip with or without cleft palate; CRC cis rs7264396 0.790 rs6121026 chr20:34266883 A/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.62 -10.41 -0.5 3.93e-22 Total cholesterol levels; CRC cis rs9467711 0.591 rs13207673 chr6:25901133 C/T cg08501292 chr6:25962987 TRIM38 1.11 9.98 0.48 1.13e-20 Autism spectrum disorder or schizophrenia; CRC cis rs7113874 0.569 rs9737401 chr11:8595652 C/T cg20771178 chr11:8615675 STK33 -0.35 -5.72 -0.3 2.42e-8 Body mass index in physically active individuals;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs7301826 0.651 rs10848206 chr12:131281471 G/C cg11011512 chr12:131303247 STX2 0.38 5.73 0.3 2.25e-8 Plasma plasminogen activator levels; CRC cis rs9303401 0.625 rs66508449 chr17:56691034 T/C cg10487724 chr17:56770010 TEX14;RAD51C 0.75 9.29 0.46 2.18e-18 Cognitive test performance; CRC cis rs6424115 1.000 rs4237 chr1:24114129 C/T cg15997130 chr1:24165203 NA 0.71 10.87 0.51 1.04e-23 Immature fraction of reticulocytes; CRC cis rs875971 0.895 rs1974769 chr7:65950614 G/A cg11764359 chr7:65958608 NA 0.63 10.13 0.49 3.71e-21 Aortic root size; CRC cis rs2991971 0.810 rs998199 chr1:45912898 A/C cg15605315 chr1:45957053 TESK2 -0.35 -5.68 -0.3 3e-8 High light scatter reticulocyte count; CRC cis rs4332037 0.539 rs11762545 chr7:2060775 C/T cg23378565 chr7:2036160 MAD1L1 -0.43 -6.09 -0.32 3.14e-9 Bipolar disorder; CRC cis rs6700896 0.866 rs6588158 chr1:66160621 T/C cg04111102 chr1:66153794 NA -0.34 -5.89 -0.31 9.43e-9 C-reactive protein;Mean corpuscular volume;Mean corpuscular hemoglobin; CRC cis rs6951245 1.000 rs78861357 chr7:1095418 C/T cg26224354 chr7:1096374 C7orf50;GPR146 -0.93 -12.11 -0.56 3.59e-28 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs853679 0.517 rs4713141 chr6:28101678 G/C cg15786705 chr6:28176104 NA 0.77 9.75 0.47 6.92e-20 Depression; CRC cis rs7666738 0.830 rs4619898 chr4:98959646 G/A cg17366294 chr4:99064904 C4orf37 0.43 7.34 0.38 1.69e-12 Colonoscopy-negative controls vs population controls; CRC cis rs1799949 0.965 rs8176130 chr17:41258043 C/T cg05368731 chr17:41323189 NBR1 0.69 10.42 0.5 3.83e-22 Menopause (age at onset); CRC cis rs2243480 1.000 rs6970243 chr7:65388490 C/A cg18252515 chr7:66147081 NA -1.08 -12.66 -0.57 3.44e-30 Diabetic kidney disease; CRC cis rs801193 1.000 rs7785213 chr7:66138978 A/C cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.43 -6.24 -0.33 1.31e-9 Aortic root size; CRC cis rs12760731 0.623 rs10913536 chr1:178315257 G/A cg00404053 chr1:178313656 RASAL2 0.74 9.2 0.45 4.23e-18 Obesity-related traits; CRC cis rs9467711 0.516 rs1165163 chr6:25863487 G/C cg08501292 chr6:25962987 TRIM38 0.64 6.69 0.35 9.65e-11 Autism spectrum disorder or schizophrenia; CRC cis rs4862750 0.872 rs13101408 chr4:187894777 G/A cg03452623 chr4:187889614 NA -0.92 -21.53 -0.76 8.7e-65 Lobe attachment (rater-scored or self-reported); CRC cis rs2982552 0.967 rs2982558 chr6:152056146 A/G cg22157087 chr6:152012887 ESR1 0.4 6.25 0.33 1.29e-9 Bone properties (heel); CRC cis rs875971 0.862 rs4149461 chr7:65744732 T/C cg00343986 chr7:65444356 GUSB -0.4 -5.68 -0.3 2.97e-8 Aortic root size; CRC cis rs9549367 0.789 rs7338235 chr13:113888687 T/C cg18105134 chr13:113819100 PROZ -0.71 -10.7 -0.51 3.98e-23 Platelet distribution width; CRC cis rs2440129 0.611 rs1126667 chr17:6902760 C/T cg03760483 chr17:6899297 ALOX12 -0.61 -11.25 -0.53 4.57e-25 Tonsillectomy; CRC cis rs1538970 0.504 rs3790585 chr1:46023356 A/T cg03146154 chr1:46216737 IPP 0.56 5.75 0.3 2.07e-8 Platelet count; CRC cis rs2486012 0.826 rs3011229 chr1:44328017 A/G cg12908607 chr1:44402522 ARTN -0.41 -5.65 -0.3 3.48e-8 Intelligence (multi-trait analysis); CRC cis rs780096 0.565 rs780104 chr2:27677691 G/A cg27432699 chr2:27873401 GPN1 -0.52 -7.96 -0.4 2.91e-14 Total body bone mineral density; CRC cis rs3743162 0.553 rs12915656 chr15:85415580 G/C cg17507749 chr15:85114479 UBE2QP1 0.53 7.07 0.36 9.07e-12 Alzheimer's disease (age of onset); CRC cis rs10504229 0.813 rs6999878 chr8:58197243 C/G cg02725872 chr8:58115012 NA -0.4 -6.62 -0.34 1.49e-10 Developmental language disorder (linguistic errors); CRC cis rs739401 0.611 rs3782069 chr11:3033275 G/A cg05729581 chr11:3078854 CARS -0.58 -8.47 -0.42 8.41e-16 Longevity; CRC cis rs889398 0.802 rs12919094 chr16:69843357 A/G cg00738113 chr16:70207722 CLEC18C 0.36 6.17 0.32 2.04e-9 Body mass index; CRC cis rs12148488 0.966 rs1867148 chr15:75339985 T/C cg09165964 chr15:75287851 SCAMP5 -0.5 -7.6 -0.39 3.08e-13 Caffeine consumption; CRC cis rs9372498 0.536 rs62422235 chr6:118971913 G/A cg01339444 chr6:118972232 C6orf204 0.58 6.22 0.32 1.48e-9 Diastolic blood pressure; CRC cis rs7584330 0.744 rs72620822 chr2:238379582 C/T cg16989719 chr2:238392110 NA -0.45 -7.68 -0.39 1.81e-13 Prostate cancer; CRC cis rs1799949 0.773 rs2137990 chr17:41317896 T/A cg19454999 chr17:41278357 BRCA1;NBR2 -0.42 -6.47 -0.34 3.54e-10 Menopause (age at onset); CRC cis rs2228479 0.717 rs11644967 chr16:89806614 T/A cg06558623 chr16:89946397 TCF25 0.94 9.67 0.47 1.24e-19 Skin colour saturation; CRC cis rs9525927 0.521 rs4942298 chr13:44798622 G/A cg19190762 chr13:44806055 NA 0.52 6.56 0.34 2.05e-10 Dupuytren's disease; CRC cis rs6087990 0.735 rs1040554 chr20:31380073 C/T cg13636640 chr20:31349939 DNMT3B 0.75 14.08 0.61 1.45e-35 Ulcerative colitis; CRC cis rs13108904 0.870 rs12642797 chr4:1245990 G/A cg20092199 chr4:1342459 KIAA1530 0.35 6.0 0.31 5.12e-9 Obesity-related traits; CRC cis rs2976388 0.609 rs2263092 chr8:143789966 A/G cg24046110 chr8:143859143 LYNX1 0.49 8.65 0.43 2.37e-16 Urinary tract infection frequency; CRC trans rs2303319 1.000 rs12471336 chr2:162265189 A/C cg11875773 chr22:50468633 TTLL8 0.72 6.04 0.32 4.16e-9 Cognitive function; CRC cis rs6463523 0.815 rs66886645 chr7:763853 C/A cg06242242 chr7:766104 PRKAR1B;HEATR2 0.9 16.13 0.66 1.56e-43 Subjective well-being; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg15650240 chr1:15736530 EFHD2 0.37 6.09 0.32 3.13e-9 Liver disease severity in Alagille syndrome; CRC cis rs6906287 0.647 rs12197337 chr6:118884092 C/T cg15382696 chr6:118971807 C6orf204 -0.33 -5.61 -0.3 4.31e-8 Electrocardiographic conduction measures; CRC cis rs853679 0.542 rs34131763 chr6:28075000 A/C cg12273811 chr6:28175739 NA 0.73 9.31 0.46 1.82e-18 Depression; CRC trans rs12960119 0.764 rs2169000 chr18:23605526 A/G cg14546394 chr8:72756863 MSC -0.32 -5.97 -0.31 5.99e-9 Rhegmatogenous retinal detachment; CRC cis rs9488822 0.676 rs12154016 chr6:116355188 C/T cg26893134 chr6:116381904 FRK 0.26 7.72 0.39 1.39e-13 Cholesterol, total;LDL cholesterol; CRC cis rs9868809 0.505 rs73080312 chr3:48737847 C/T cg07636037 chr3:49044803 WDR6 -0.84 -6.09 -0.32 3.22e-9 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; CRC cis rs6761276 0.727 rs6743376 chr2:113832333 C/A cg24553058 chr2:113831203 IL1F10 0.42 6.42 0.33 4.87e-10 Protein quantitative trait loci; CRC cis rs2439831 0.850 rs9944216 chr15:44160773 C/G cg02155558 chr15:43621948 ADAL;LCMT2 -0.67 -7.2 -0.37 4.1e-12 Lung cancer in ever smokers; CRC cis rs7918232 0.830 rs9833 chr10:27400861 G/A cg14240646 chr10:27532245 ACBD5 -0.82 -9.18 -0.45 5.02e-18 Breast cancer; CRC cis rs7927592 0.913 rs12272917 chr11:68263370 T/C cg01657329 chr11:68192670 LRP5 -0.46 -6.5 -0.34 2.97e-10 Total body bone mineral density; CRC cis rs889398 0.594 rs7202233 chr16:69894432 A/G cg00738113 chr16:70207722 CLEC18C -0.34 -5.9 -0.31 8.8e-9 Body mass index; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg17256253 chr4:968603 DGKQ -0.37 -6.37 -0.33 6.5e-10 Liver disease severity in Alagille syndrome; CRC cis rs6714710 0.603 rs35424768 chr2:98395653 A/C cg26665480 chr2:98280029 ACTR1B 0.52 7.2 0.37 4.06e-12 Posterior cortical atrophy and Alzheimer's disease; CRC cis rs1832871 0.672 rs62437159 chr6:158697705 C/T cg07165851 chr6:158734300 TULP4 0.6 7.59 0.39 3.38e-13 Height; CRC cis rs9527 0.590 rs1926029 chr10:104855670 C/T cg04362960 chr10:104952993 NT5C2 0.64 9.22 0.45 3.69e-18 Arsenic metabolism; CRC cis rs7412746 0.658 rs11204750 chr1:150939744 C/A cg15448220 chr1:150897856 SETDB1 0.55 8.02 0.4 1.89e-14 Melanoma; CRC cis rs10411161 0.702 rs6509592 chr19:52393150 G/A cg23010048 chr19:52391257 ZNF577 0.49 5.88 0.31 1.03e-8 Breast cancer; CRC cis rs677665 0.918 rs11590326 chr1:9339205 A/G cg25755851 chr1:9335794 NA -0.6 -8.31 -0.42 2.48e-15 Eosinophil percentage of white cells; CRC cis rs11958404 0.932 rs72818104 chr5:157437632 T/C cg05962755 chr5:157440814 NA 1.01 12.88 0.58 5.12e-31 IgG glycosylation; CRC cis rs763121 0.853 rs9622833 chr22:39000397 G/A cg06544989 chr22:39130855 UNC84B 0.42 6.23 0.32 1.44e-9 Menopause (age at onset); CRC cis rs6460942 0.915 rs17541464 chr7:12462675 A/G cg06484146 chr7:12443880 VWDE -0.69 -8.55 -0.43 4.81e-16 Coronary artery disease; CRC cis rs9733 0.596 rs12089731 chr1:150647798 T/C cg10589385 chr1:150898437 SETDB1 0.28 5.98 0.31 5.86e-9 Tonsillectomy; CRC cis rs9311676 0.656 rs68021431 chr3:58403136 A/G cg06643156 chr3:58380774 PXK 0.42 6.39 0.33 5.71e-10 Systemic lupus erythematosus; CRC cis rs6499129 1.000 rs55966046 chr16:67466726 C/A cg26727032 chr16:67993705 SLC12A4 -0.54 -5.87 -0.31 1.07e-8 Waist-to-hip ratio adjusted for body mass index; CRC cis rs6831352 0.879 rs1230154 chr4:99988659 C/T cg13256891 chr4:100009986 ADH5 0.56 7.78 0.39 9.2e-14 Alcohol dependence; CRC cis rs67478160 0.644 rs7159810 chr14:104294117 T/G cg08213375 chr14:104286397 PPP1R13B 0.64 13.04 0.58 1.3e-31 Schizophrenia; CRC cis rs478304 0.903 rs12293022 chr11:65531698 C/T cg27068330 chr11:65405492 SIPA1 0.44 6.55 0.34 2.26e-10 Acne (severe); CRC cis rs7705042 0.659 rs11743029 chr5:141509282 G/A cg07392085 chr5:141489673 NDFIP1 -0.41 -5.94 -0.31 7.23e-9 Asthma; CRC cis rs28374715 0.662 rs513280 chr15:41482800 T/C cg18705301 chr15:41695430 NDUFAF1 0.87 13.27 0.59 1.74e-32 Ulcerative colitis; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg25745773 chr20:33264905 PIGU 0.45 6.36 0.33 6.89e-10 Anxiety disorder; CRC cis rs3096299 0.719 rs2965817 chr16:89513234 C/T cg00750074 chr16:89608354 SPG7 -0.51 -7.96 -0.4 2.81e-14 Multiple myeloma (IgH translocation); CRC trans rs8002861 0.870 rs9525855 chr13:44431660 A/G cg17145862 chr1:211918768 LPGAT1 0.72 14.34 0.62 1.46e-36 Leprosy; CRC cis rs6764363 0.504 rs4684333 chr3:278661 A/C cg02057681 chr3:285234 CHL1 0.41 6.89 0.36 2.79e-11 Sudden cardiac arrest; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg01368133 chr4:89513561 HERC3 0.48 6.4 0.33 5.31e-10 Anxiety disorder; CRC cis rs2404602 1.000 rs6495206 chr15:76870963 C/T cg23625390 chr15:77176239 SCAPER 0.57 8.71 0.43 1.47e-16 Blood metabolite levels; CRC trans rs10982213 0.830 rs2274163 chr9:117188714 C/T cg25580254 chr12:8088937 SLC2A3 -0.49 -7.5 -0.38 6.11e-13 Interleukin-6 levels; CRC cis rs11190604 0.943 rs11190568 chr10:102224277 C/T cg16342193 chr10:102329863 NA -0.4 -6.45 -0.34 3.91e-10 Palmitoleic acid (16:1n-7) levels; CRC trans rs1814175 0.817 rs10839318 chr11:49657511 G/C cg15704280 chr7:45808275 SEPT13 -0.98 -19.1 -0.73 2.9e-55 Height; CRC cis rs11245387 0.633 rs2086945 chr10:126543993 C/T cg03572133 chr10:126482885 NA -0.38 -5.98 -0.31 5.7e-9 Response to bronchodilator in chronic obstructive pulmonary disease (change in FEV1); CRC cis rs3617 0.573 rs2336668 chr3:52919096 G/T cg18099408 chr3:52552593 STAB1 0.34 5.76 0.3 1.95e-8 Red blood cell count;Autism spectrum disorder or schizophrenia; CRC cis rs9488822 0.676 rs12196579 chr6:116351724 G/T cg18764771 chr6:116381957 FRK 0.27 7.7 0.39 1.61e-13 Cholesterol, total;LDL cholesterol; CRC cis rs9733 0.519 rs10788792 chr1:150638572 T/G cg18016565 chr1:150552671 MCL1 0.47 6.82 0.35 4.33e-11 Tonsillectomy; CRC cis rs2735413 0.958 rs7192416 chr16:78063143 C/T cg04733911 chr16:78082701 NA -0.36 -6.01 -0.31 4.97e-9 Systolic blood pressure (alcohol consumption interaction); CRC cis rs8180040 0.764 rs11712716 chr3:47193432 T/C cg02527881 chr3:46936655 PTH1R -0.4 -7.44 -0.38 8.8e-13 Colorectal cancer; CRC cis rs3816788 0.837 rs6557640 chr8:21771731 A/T cg17168535 chr8:21777572 XPO7 0.6 9.96 0.48 1.33e-20 Lung cancer in ever smokers; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg12314527 chr22:19110193 DGCR2 0.39 6.93 0.36 2.19e-11 Liver disease severity in Alagille syndrome; CRC cis rs9326248 0.768 rs4936366 chr11:117026885 G/A cg11861562 chr11:117069780 TAGLN 0.35 6.47 0.34 3.57e-10 Blood protein levels; CRC cis rs6964587 1.000 rs28735847 chr7:91592755 T/C cg17063962 chr7:91808500 NA 0.81 14.19 0.62 5.71e-36 Breast cancer; CRC cis rs7677751 0.806 rs7698425 chr4:55090656 C/T cg17187183 chr4:55093834 PDGFRA 0.52 7.53 0.38 4.78e-13 Corneal astigmatism; CRC cis rs739401 0.572 rs739400 chr11:3016520 G/A cg05729581 chr11:3078854 CARS -0.56 -8.3 -0.42 2.77e-15 Longevity; CRC cis rs13256369 1.000 rs12550458 chr8:8567832 G/A cg17143192 chr8:8559678 CLDN23 0.48 6.14 0.32 2.41e-9 Obesity-related traits; CRC cis rs1215050 0.791 rs165247 chr4:98692399 A/G cg05340658 chr4:99064831 C4orf37 0.48 7.12 0.37 6.81e-12 Waist-to-hip ratio adjusted for body mass index; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg26630792 chr5:137515009 BRD8;KIF20A 0.45 6.23 0.32 1.41e-9 Response to antipsychotic treatment; CRC cis rs9549367 0.713 rs1323315 chr13:113859658 T/C cg24300038 chr13:113819356 PROZ 0.5 6.61 0.34 1.52e-10 Platelet distribution width; CRC cis rs9807989 0.507 rs7584093 chr2:102997721 C/T cg03938978 chr2:103052716 IL18RAP 0.59 10.12 0.49 3.77e-21 Asthma; CRC cis rs1572438 0.831 rs4960373 chr6:855764 A/C cg13447295 chr6:887704 NA -0.43 -6.52 -0.34 2.71e-10 Aging; CRC cis rs17666538 0.535 rs7822126 chr8:643810 A/G cg07234876 chr8:600039 NA 0.73 7.64 0.39 2.37e-13 IgG glycosylation; CRC cis rs3736485 0.844 rs28680710 chr15:51788991 G/C cg08986416 chr15:51914746 DMXL2 -0.44 -6.21 -0.32 1.61e-9 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs11105298 0.891 rs10858864 chr12:89846230 C/T cg00757033 chr12:89920650 WDR51B 0.37 6.19 0.32 1.8e-9 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; CRC cis rs9640161 0.789 rs1464752 chr7:150021284 C/T cg13722127 chr7:150037890 RARRES2 0.49 7.68 0.39 1.82e-13 Blood protein levels;Circulating chemerin levels; CRC cis rs1784581 0.588 rs9295178 chr6:162419226 T/A cg17173639 chr6:162384350 PARK2 0.6 9.72 0.47 8.36e-20 Itch intensity from mosquito bite; CRC trans rs1005277 0.522 rs289650 chr10:37975505 G/T cg23533926 chr12:111358616 MYL2 -0.42 -6.25 -0.33 1.27e-9 Extrinsic epigenetic age acceleration; CRC cis rs9325144 0.505 rs7138977 chr12:38642109 G/A cg26384229 chr12:38710491 ALG10B 0.53 7.85 0.4 5.81e-14 Morning vs. evening chronotype; CRC cis rs2280630 0.529 rs784505 chr3:39168757 G/A cg01426195 chr3:39028469 NA 0.42 7.12 0.37 6.89e-12 Verbal declarative memory; CRC cis rs6951245 1.000 rs78896566 chr7:1080182 C/G cg03188948 chr7:1209495 NA 0.63 6.54 0.34 2.29e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs1983170 1.000 rs10874785 chr1:92015243 G/A cg02896835 chr1:92012615 NA 0.43 5.9 0.31 8.97e-9 Eosinophil percentage of white cells; CRC cis rs4727027 0.866 rs2373437 chr7:148779032 T/C cg23583168 chr7:148888333 NA -0.86 -14.36 -0.62 1.23e-36 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC cis rs1129187 0.935 rs4987173 chr6:42931224 G/A cg26304593 chr6:42947056 PEX6 -0.41 -5.87 -0.31 1.08e-8 Alzheimer's disease in APOE e4+ carriers; CRC cis rs2115630 1.000 rs8037423 chr15:85355494 C/T cg11189052 chr15:85197271 WDR73 -0.57 -9.12 -0.45 7.48e-18 P wave terminal force; CRC cis rs1129187 0.818 rs9462858 chr6:42946490 C/A cg27588902 chr6:42928151 GNMT -0.37 -6.59 -0.34 1.71e-10 Alzheimer's disease in APOE e4+ carriers; CRC cis rs6456156 0.586 rs2001115 chr6:167486218 A/C cg07741184 chr6:167504864 NA 0.38 6.65 0.34 1.21e-10 Primary biliary cholangitis; CRC cis rs11098499 0.644 rs7676296 chr4:120555687 A/G cg24375607 chr4:120327624 NA 0.48 7.49 0.38 6.31e-13 Corneal astigmatism; CRC trans rs6951245 0.572 rs75818004 chr7:1047572 C/T cg13565492 chr6:43139072 SRF -0.86 -6.3 -0.33 9.6e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs11098499 0.954 rs10518328 chr4:120401779 G/A cg24375607 chr4:120327624 NA 0.49 7.69 0.39 1.77e-13 Corneal astigmatism; CRC cis rs703842 1.000 rs4646536 chr12:58157988 A/G cg04478727 chr12:58166393 METTL1;FAM119B 0.41 5.67 0.3 3.2e-8 Multiple sclerosis; CRC cis rs8177253 1.000 rs6439439 chr3:133481498 G/T cg11941060 chr3:133502564 NA -0.59 -10.2 -0.49 2.16e-21 Iron status biomarkers; CRC cis rs2404602 0.669 rs17464903 chr15:77195486 A/G cg23625390 chr15:77176239 SCAPER 0.47 6.66 0.34 1.17e-10 Blood metabolite levels; CRC cis rs6724607 1.000 rs13410230 chr2:191446252 A/G cg27211696 chr2:191398769 TMEM194B 0.39 5.89 0.31 9.46e-9 Pulse pressure; CRC cis rs9911578 0.839 rs7208505 chr17:57187729 C/T cg12560992 chr17:57184187 TRIM37 0.92 17.24 0.69 6.7e-48 Intelligence (multi-trait analysis); CRC trans rs10242455 0.557 rs2404487 chr7:99038057 G/A cg09045935 chr12:6379348 NA 1.13 9.23 0.45 3.42e-18 Blood metabolite levels; CRC trans rs3780486 0.874 rs10813955 chr9:33141791 C/T cg04842962 chr6:43655489 MRPS18A 1.15 23.79 0.8 1.82e-73 IgG glycosylation; CRC cis rs600806 0.821 rs3879451 chr1:109909269 C/T cg23032129 chr1:109941072 SORT1 -0.28 -6.0 -0.31 5.26e-9 Intelligence (multi-trait analysis); CRC cis rs7917772 0.503 rs7093285 chr10:104374815 G/C cg11453585 chr10:104263688 ACTR1A;SUFU 0.87 15.72 0.65 6.34e-42 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC cis rs8067545 0.717 rs34401389 chr17:19989436 A/T cg13482628 chr17:19912719 NA 0.48 7.75 0.39 1.18e-13 Schizophrenia; CRC cis rs6504622 1.000 rs2003539 chr17:45025319 A/G cg16759221 chr17:45003025 GOSR2 0.44 6.93 0.36 2.27e-11 Orofacial clefts; CRC cis rs12295403 0.723 rs12787397 chr11:18687025 C/T cg07538406 chr11:18686895 NA -0.47 -5.93 -0.31 7.61e-9 Ovarian reserve; CRC cis rs7843479 0.898 rs4311656 chr8:21802276 T/G cg17168535 chr8:21777572 XPO7 0.58 9.45 0.46 6.48e-19 Mean corpuscular volume; CRC cis rs7727544 0.716 rs11955347 chr5:131567924 G/A cg18758796 chr5:131593413 PDLIM4 0.36 6.63 0.34 1.37e-10 Blood metabolite levels; CRC cis rs1448094 0.817 rs73176252 chr12:86347649 T/A cg18827107 chr12:86230957 RASSF9 -0.43 -6.85 -0.35 3.64e-11 Major depressive disorder; CRC cis rs4803468 1.000 rs3213861 chr19:41919944 A/C cg09537434 chr19:41945824 ATP5SL -0.97 -18.81 -0.72 4.3e-54 Height; CRC cis rs3789045 0.837 rs57450685 chr1:204580832 A/T cg17419461 chr1:204415978 PIK3C2B -0.52 -7.43 -0.38 9.72e-13 Educational attainment (college completion); CRC cis rs2204008 0.744 rs11180504 chr12:38236313 C/T cg13010199 chr12:38710504 ALG10B 0.45 5.82 0.31 1.39e-8 Bladder cancer; CRC cis rs3733585 0.699 rs7694997 chr4:9947811 A/G cg11266682 chr4:10021025 SLC2A9 -0.46 -9.18 -0.45 4.77e-18 Cleft plate (environmental tobacco smoke interaction); CRC cis rs10782582 0.609 rs11584577 chr1:76242378 A/G cg03433033 chr1:76189801 ACADM -0.4 -5.77 -0.3 1.88e-8 Daytime sleep phenotypes; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg23191292 chr6:157099924 ARID1B 0.47 6.57 0.34 2.01e-10 Response to antipsychotic treatment; CRC cis rs1348850 0.914 rs2121430 chr2:178318375 A/G cg22681709 chr2:178499509 PDE11A -0.35 -6.38 -0.33 6.15e-10 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs6570726 0.967 rs9497316 chr6:145792387 G/T cg23711669 chr6:146136114 FBXO30 -0.62 -10.38 -0.5 5.18e-22 Lobe attachment (rater-scored or self-reported); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg10891025 chr15:44828937 EIF3J 0.42 6.09 0.32 3.18e-9 Intelligence (multi-trait analysis); CRC cis rs2836754 1.000 rs2836754 chr21:40291740 C/T cg02119577 chr21:40195074 ETS2 0.36 6.33 0.33 8.23e-10 Crohn's disease;Body mass index; CRC trans rs61101201 0.962 rs10835790 chr11:31610022 C/T cg07245980 chr10:52390973 NA -0.58 -6.59 -0.34 1.78e-10 Optic disc area; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg23729963 chr8:94753249 RBM12B 0.44 6.64 0.34 1.28e-10 Intelligence (multi-trait analysis); CRC cis rs875971 0.545 rs6460298 chr7:65907770 T/C cg18876405 chr7:65276391 NA 0.46 6.42 0.33 4.74e-10 Aortic root size; CRC cis rs28386778 0.897 rs1877318 chr17:61819960 G/A cg23090583 chr17:61904693 PSMC5;FTSJ3 1.03 19.53 0.73 5.78e-57 Prudent dietary pattern; CRC cis rs11792861 0.591 rs2275641 chr9:111696389 G/C cg14432460 chr9:111696404 IKBKAP;C9orf6 0.51 7.27 0.37 2.64e-12 Menarche (age at onset); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg11970458 chr16:31213481 PYCARD 0.48 6.9 0.36 2.65e-11 Response to antipsychotic treatment; CRC cis rs17384381 1.000 rs12758237 chr1:85870783 G/A cg16011679 chr1:85725395 C1orf52 0.64 6.56 0.34 2.11e-10 Lobe attachment (rater-scored or self-reported); CRC cis rs9362426 0.708 rs6907825 chr6:88102822 C/T cg08069147 chr6:88032118 GJB7;C6orf162 0.48 6.4 0.33 5.42e-10 Depressive episodes in bipolar disorder; CRC cis rs2976388 0.556 rs4736321 chr8:143822194 C/T cg04969067 chr8:143858791 LYNX1 -0.41 -6.12 -0.32 2.64e-9 Urinary tract infection frequency; CRC cis rs754466 0.580 rs10824573 chr10:79540969 T/C cg26805224 chr10:79626177 DLG5 -0.49 -7.3 -0.37 2.13e-12 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs896854 0.517 rs1011795 chr8:95951073 G/A cg16049864 chr8:95962084 TP53INP1 -0.47 -7.42 -0.38 9.88e-13 Type 2 diabetes; CRC cis rs9486719 1.000 rs12214469 chr6:97019471 G/T cg18709589 chr6:96969512 KIAA0776 -0.52 -5.85 -0.31 1.21e-8 Migraine;Coronary artery disease; CRC cis rs6502050 0.635 rs9889327 chr17:80087839 G/A cg25804541 chr17:80189381 SLC16A3 -0.3 -5.84 -0.31 1.24e-8 Life satisfaction; CRC cis rs11971779 0.680 rs11760420 chr7:139114768 C/T cg07862535 chr7:139043722 LUC7L2 0.57 7.35 0.38 1.61e-12 Diisocyanate-induced asthma; CRC cis rs116095464 0.558 rs10068203 chr5:206618 C/T cg22496380 chr5:211416 CCDC127 -0.95 -9.33 -0.46 1.66e-18 Breast cancer; CRC cis rs736408 0.522 rs998909 chr3:52805093 A/G cg05573699 chr3:52720067 GNL3;PBRM1 -0.47 -6.84 -0.35 3.87e-11 Bipolar disorder; CRC cis rs1023500 0.573 rs4822088 chr22:42470589 G/C cg25452165 chr22:42524984 CYP2D6 0.4 6.04 0.32 4.11e-9 Schizophrenia; CRC cis rs916888 0.821 rs70602 chr17:44859715 T/C cg17911788 chr17:44343683 NA 0.56 6.86 0.35 3.4e-11 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs79349575 0.783 rs61576918 chr17:46985593 A/C cg22482690 chr17:47019901 SNF8 0.49 8.2 0.41 5.33e-15 Type 2 diabetes; CRC cis rs9549367 0.713 rs553316 chr13:113838015 A/G cg18105134 chr13:113819100 PROZ 0.85 13.44 0.6 3.84e-33 Platelet distribution width; CRC cis rs9560113 1.000 rs4773379 chr13:112176088 G/C cg10483660 chr13:112241077 NA 0.36 5.78 0.3 1.74e-8 Menarche (age at onset); CRC cis rs12530845 0.943 rs60858457 chr7:135336918 T/C cg23117316 chr7:135346802 PL-5283 -0.41 -5.82 -0.31 1.37e-8 Red blood cell traits; CRC cis rs172166 0.694 rs203876 chr6:28046673 T/C cg12273811 chr6:28175739 NA 0.59 8.64 0.43 2.56e-16 Cardiac Troponin-T levels; CRC cis rs908922 0.676 rs7529136 chr1:152516389 T/C cg23254163 chr1:152506842 NA 0.44 8.57 0.43 4.11e-16 Hair morphology; CRC cis rs4974559 0.739 rs59810282 chr4:1320968 A/G cg02980000 chr4:1222292 CTBP1 0.72 8.01 0.4 1.94e-14 Systolic blood pressure; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg13524873 chr10:104953185 NT5C2 0.38 6.19 0.32 1.81e-9 Liver disease severity in Alagille syndrome; CRC trans rs7395662 0.791 rs4347396 chr11:48895929 T/C cg21153622 chr11:89784906 NA 0.47 7.44 0.38 8.86e-13 HDL cholesterol; CRC cis rs2153535 0.526 rs9406179 chr6:8538224 G/A cg07606381 chr6:8435919 SLC35B3 0.68 11.12 0.52 1.37e-24 Motion sickness; CRC cis rs875971 0.545 rs7811204 chr7:65852200 G/A cg03233332 chr7:66118400 NA -0.43 -5.87 -0.31 1.05e-8 Aortic root size; CRC cis rs3858526 0.523 rs10838750 chr11:5886246 C/T cg05234568 chr11:5960015 NA 0.67 9.76 0.47 6.49e-20 DNA methylation (variation); CRC cis rs5750830 0.569 rs5750809 chr22:39791491 T/G cg24399712 chr22:39784796 NA -0.48 -9.1 -0.45 8.71e-18 Intelligence (multi-trait analysis); CRC cis rs13118159 0.509 rs7688922 chr4:1361011 T/C cg05025164 chr4:1340916 KIAA1530 0.59 8.37 0.42 1.66e-15 Longevity; CRC cis rs737337 0.623 rs12974173 chr19:11333359 A/T cg00586551 chr19:11347513 LOC55908;DOCK6 0.8 8.84 0.44 5.7e-17 HDL cholesterol;HDL cholesterol levels; CRC cis rs6460942 0.915 rs10488158 chr7:12508894 C/T cg06484146 chr7:12443880 VWDE -0.75 -7.42 -0.38 9.99e-13 Coronary artery disease; CRC trans rs79976124 0.719 rs34488909 chr6:66637850 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.72 9.09 0.45 9.43e-18 Type 2 diabetes; CRC trans rs3960554 0.673 rs57358338 chr7:75732923 T/C cg19862616 chr7:65841803 NCRNA00174 0.65 7.87 0.4 5.09e-14 Eotaxin levels; CRC cis rs7945705 0.818 rs2742552 chr11:8876852 C/T cg21881798 chr11:8931708 C11orf17;ST5 -0.71 -12.41 -0.56 2.75e-29 Hemoglobin concentration; CRC trans rs6678914 1.000 rs12132085 chr1:202188932 A/G cg19977628 chr5:1262072 TERT 0.43 6.2 0.32 1.65e-9 Breast cancer (estrogen-receptor negative);Breast cancer; CRC cis rs870825 0.929 rs72689266 chr4:185591053 T/C cg07424746 chr4:185654737 MLF1IP -0.59 -5.82 -0.31 1.4e-8 Blood protein levels; CRC cis rs3764563 0.877 rs4019751 chr19:15740716 T/G cg20725493 chr19:15740067 CYP4F8 -0.73 -7.59 -0.39 3.41e-13 Inflammatory biomarkers; CRC cis rs877282 0.945 rs12776447 chr10:790625 A/G cg17470449 chr10:769945 NA 0.68 9.03 0.45 1.48e-17 Uric acid levels; CRC cis rs8044995 0.563 rs56899435 chr16:68395675 G/A cg09835421 chr16:68378352 PRMT7 -0.78 -8.17 -0.41 6.92e-15 Schizophrenia; CRC trans rs12599106 0.709 rs1501462 chr16:34964515 A/T cg18110333 chr6:292329 DUSP22 -0.68 -10.05 -0.48 6.7e-21 Menopause (age at onset); CRC trans rs2727020 0.576 rs10839305 chr11:49598733 T/C cg15704280 chr7:45808275 SEPT13 -0.94 -18.06 -0.71 3.66e-51 Coronary artery disease; CRC cis rs654950 0.774 rs941972 chr1:42040740 T/C cg06885757 chr1:42089581 HIVEP3 -0.47 -7.96 -0.4 2.84e-14 Airway imaging phenotypes; CRC cis rs6502050 0.634 rs11077973 chr17:80095191 C/T cg19223190 chr17:80058835 NA 0.4 6.36 0.33 6.88e-10 Life satisfaction; CRC cis rs7914558 1.000 rs1890184 chr10:104748459 A/C cg04362960 chr10:104952993 NT5C2 0.62 9.49 0.46 4.92e-19 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs6694672 0.867 rs7554802 chr1:197148599 T/C cg13682187 chr1:196946512 CFHR5 0.43 6.97 0.36 1.73e-11 Asthma; CRC cis rs9303542 0.625 rs8073963 chr17:46609918 G/A cg04904318 chr17:46607828 HOXB1 0.44 5.9 0.31 8.83e-9 Ovarian cancer;Epithelial ovarian cancer; CRC cis rs4363385 0.818 rs2787629 chr1:153011966 A/G cg25856811 chr1:152973957 SPRR3 -0.25 -6.99 -0.36 1.51e-11 Inflammatory skin disease; CRC cis rs7208859 0.623 rs9890558 chr17:29110355 T/C cg01831904 chr17:28903510 LRRC37B2 -0.63 -6.45 -0.33 4.07e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs9287719 0.967 rs1541573 chr2:10773385 T/G cg00105475 chr2:10696890 NA 0.45 7.19 0.37 4.48e-12 Prostate cancer; CRC trans rs17607347 0.738 rs17669912 chr16:72346595 T/C cg27230510 chr3:50404023 CACNA2D2 -0.53 -6.11 -0.32 2.76e-9 Intelligence (multi-trait analysis); CRC cis rs6963495 0.818 rs6956249 chr7:105149743 A/T cg13798780 chr7:105162888 PUS7 0.66 8.06 0.41 1.39e-14 Bipolar disorder (body mass index interaction); CRC cis rs1670533 1.000 rs6822863 chr4:1055606 G/A cg27284194 chr4:1044797 NA 0.51 6.48 0.34 3.41e-10 Recombination rate (females); CRC cis rs6500602 0.702 rs4786511 chr16:4571645 C/T cg08645402 chr16:4508243 NA 0.64 11.48 0.53 7.03e-26 Schizophrenia; CRC trans rs6598955 0.671 rs10902732 chr1:26606174 A/C cg07461501 chr17:79650226 HGS;ARL16 -0.52 -6.19 -0.32 1.77e-9 Obesity-related traits; CRC cis rs1552244 1.000 rs13319597 chr3:10126312 A/C cg16606324 chr3:10149918 C3orf24 -0.73 -10.16 -0.49 2.82e-21 Alzheimer's disease; CRC cis rs365302 1.000 rs449385 chr6:159644318 A/G cg14500486 chr6:159655392 FNDC1 0.44 6.61 0.34 1.59e-10 Coronary heart disease; CRC cis rs2073300 0.609 rs3736755 chr20:23377642 C/T cg12062639 chr20:23401060 NAPB 0.72 6.79 0.35 5.36e-11 Peripheral arterial disease (traffic-related air pollution interaction); CRC trans rs9956878 0.555 rs8085188 chr18:73544676 A/G cg05607246 chr6:139695661 CITED2 -0.41 -6.47 -0.34 3.55e-10 Obesity-related traits; CRC cis rs17711722 0.727 rs35850374 chr7:65357776 A/G cg05627663 chr7:65219948 SNORA22;CCT6P1 0.5 7.48 0.38 6.79e-13 Calcium levels; CRC cis rs17125944 0.505 rs28568967 chr14:53223060 A/G cg00686598 chr14:53173677 PSMC6 1.17 10.87 0.51 1.05e-23 Alzheimer's disease (late onset); CRC cis rs6432018 1.000 rs6745213 chr2:9741546 A/G cg12832956 chr2:9616023 IAH1 -0.37 -5.65 -0.3 3.48e-8 Heart rate variability traits; CRC cis rs1609391 0.561 rs9817967 chr3:136629490 G/A cg15507776 chr3:136538369 TMEM22 0.34 6.19 0.32 1.83e-9 Neuroticism; CRC cis rs780094 0.544 rs2303370 chr2:27651375 C/T cg02592271 chr2:27665507 KRTCAP3 -0.25 -5.75 -0.3 2e-8 Calcium levels;Fasting blood insulin;Metabolic traits;Triglyceride levels;Fasting plasma glucose;Urate levels in overweight individuals;Urate levels in obese individuals;Uric acid levels;Height;Age-related diseases, mortality and associated endophenotypes;Renal underexcretion gout;Fasting blood glucose (BMI interaction);Urate levels;Gondoic acid (20:1n-9) levels;Fasting blood insulin (BMI interaction);Triglycerides;Plasma omega-3 polyunsaturated fatty acid levels (docosapentaenoic acid);Type 2 diabetes;Nonalcoholic fatty liver disease;Hypertriglyceridemia;C-reactive protein;Age-related disease endophenotypes;LDL cholesterol;Metabolic syndrome;Crohn's disease;Alcohol consumption (drinks per week);Homeostasis model assessment of insulin resistance;Alcohol consumption;Red blood cell count;Fasting blood glucose; CRC cis rs4973397 0.810 rs12993290 chr2:232279687 G/A cg13347044 chr2:232276743 NA 0.5 7.1 0.36 7.82e-12 Anti-saccade response; CRC cis rs1971762 0.522 rs10747680 chr12:54077776 T/G cg06632207 chr12:54070931 ATP5G2 0.41 7.07 0.36 9.17e-12 Height; CRC cis rs7811142 0.830 rs77861211 chr7:99962096 T/C cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.94 12.66 0.57 3.42e-30 Platelet count; CRC cis rs2019137 0.560 rs7421852 chr2:113990261 G/A cg19083407 chr2:113993142 PAX8;LOC440839;LOC654433 0.57 8.34 0.42 2.07e-15 Lymphocyte counts; CRC trans rs8002861 0.658 rs9533635 chr13:44397921 C/A cg17145862 chr1:211918768 LPGAT1 -0.51 -8.49 -0.42 7.05e-16 Leprosy; CRC cis rs9487051 0.768 rs461487 chr6:109525504 A/G cg21918786 chr6:109611834 NA -0.33 -5.7 -0.3 2.65e-8 Reticulocyte fraction of red cells; CRC cis rs4819052 0.885 rs9980676 chr21:46665430 A/G cg02159808 chr21:46707872 POFUT2;LOC642852 0.5 6.61 0.34 1.57e-10 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs10924970 0.649 rs4659656 chr1:235384114 A/G cg09010748 chr1:235293032 TOMM20 -0.4 -5.82 -0.31 1.39e-8 Asthma; CRC cis rs9910055 0.747 rs2905981 chr17:42238625 C/T cg09913183 chr17:42254507 C17orf65;ASB16 0.58 8.49 0.42 7.43e-16 Total body bone mineral density; CRC cis rs270601 0.661 rs10036208 chr5:131571323 T/C cg09877947 chr5:131593287 PDLIM4 0.58 10.21 0.49 1.93e-21 Acylcarnitine levels; CRC trans rs11039798 0.591 rs74992349 chr11:49019252 G/A cg03929089 chr4:120376271 NA 0.64 6.46 0.34 3.68e-10 Axial length; CRC cis rs12594515 1.000 rs8039974 chr15:45986665 A/G cg01629716 chr15:45996671 NA 0.41 8.41 0.42 1.29e-15 Waist circumference;Weight; CRC cis rs1048238 0.506 rs848212 chr1:16263452 A/G cg21385522 chr1:16154831 NA -0.61 -8.95 -0.44 2.72e-17 Systolic blood pressure; CRC cis rs4713118 0.662 rs9380045 chr6:28025279 A/G cg02683197 chr6:28174875 NA 0.75 9.8 0.48 4.46e-20 Parkinson's disease; CRC cis rs11148252 0.574 rs9536247 chr13:53279542 T/C cg12458913 chr13:53173898 NA 0.8 14.88 0.63 1.15e-38 Lewy body disease; CRC cis rs4891159 0.824 rs17059362 chr18:74144307 G/A cg24786174 chr18:74118243 ZNF516 -0.85 -14.62 -0.63 1.17e-37 Longevity; CRC cis rs6504622 0.935 rs62075889 chr17:45028037 A/T cg16759221 chr17:45003025 GOSR2 0.45 7.17 0.37 4.83e-12 Orofacial clefts; CRC cis rs6840360 1.000 rs6849050 chr4:152599902 C/T cg09659197 chr4:152720779 NA 0.52 11.28 0.53 3.52e-25 Intelligence (multi-trait analysis); CRC cis rs12477438 0.871 rs62156364 chr2:99695097 A/G cg14399236 chr2:99771627 LIPT1;TSGA10 -0.65 -7.97 -0.4 2.62e-14 Chronic sinus infection; CRC cis rs10512697 0.803 rs11739180 chr5:3580077 C/A cg19473799 chr5:3511975 NA -0.72 -5.69 -0.3 2.81e-8 Immune response to smallpox vaccine (IL-6); CRC cis rs57221529 0.766 rs72706606 chr5:558609 T/C cg16447950 chr5:562315 NA -0.84 -11.5 -0.54 6.14e-26 Lung disease severity in cystic fibrosis; CRC trans rs8073060 0.586 rs225250 chr17:33941963 A/G cg19694781 chr19:47549865 TMEM160 -1.07 -15.45 -0.65 6.9e-41 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; CRC cis rs35306767 0.855 rs61830932 chr10:934183 T/C cg20503657 chr10:835505 NA 0.96 11.85 0.55 3.3e-27 Eosinophil percentage of granulocytes; CRC cis rs3785574 0.962 rs58131426 chr17:61854375 T/C cg06873352 chr17:61820015 STRADA 0.5 8.06 0.41 1.45e-14 Height; CRC cis rs60871478 0.786 rs55899111 chr7:827843 C/G cg05535760 chr7:792225 HEATR2 -1.04 -13.4 -0.59 5.46e-33 Cerebrospinal P-tau181p levels; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg02700172 chr2:241377874 GPC1 0.41 6.01 0.31 5.04e-9 Intelligence (multi-trait analysis); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg15015892 chr1:151810887 C2CD4D;LOC100132111 0.2 6.02 0.31 4.55e-9 Liver disease severity in Alagille syndrome; CRC cis rs10888329 0.744 rs6587433 chr1:248355279 G/A cg00666640 chr1:248458726 OR2T12 0.43 7.05 0.36 1.05e-11 Autism spectrum disorder; CRC cis rs951366 0.559 rs823101 chr1:205667006 T/C cg24503407 chr1:205819492 PM20D1 0.75 10.69 0.51 4.33e-23 Menarche (age at onset); CRC cis rs1448094 0.765 rs4919773 chr12:86337559 C/T cg25456477 chr12:86230367 RASSF9 0.33 5.69 0.3 2.82e-8 Major depressive disorder; CRC cis rs1552244 0.554 rs58020561 chr3:10054682 A/G cg18598329 chr3:10140678 FANCD2;C3orf24 -0.53 -7.51 -0.38 5.61e-13 Alzheimer's disease; CRC cis rs863345 0.604 rs1894038 chr1:158455947 T/C cg12129480 chr1:158549410 OR10X1 -0.29 -6.07 -0.32 3.47e-9 Pneumococcal bacteremia; CRC cis rs597539 0.652 rs544370 chr11:68653232 C/T cg21963583 chr11:68658836 MRPL21 0.6 11.31 0.53 2.93e-25 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs11626933 0.959 rs8005973 chr14:90774951 C/T cg14092571 chr14:90743983 NA -0.89 -15.02 -0.64 3.48e-39 Gut microbiota (bacterial taxa); CRC cis rs2243480 1.000 rs1873494 chr7:65649899 T/C cg25985355 chr7:65971099 NA 0.52 6.01 0.31 4.92e-9 Diabetic kidney disease; CRC trans rs9329221 0.527 rs10903328 chr8:10332167 G/C cg06636001 chr8:8085503 FLJ10661 0.51 7.51 0.38 5.7e-13 Neuroticism; CRC cis rs1799949 0.965 rs799908 chr17:41278916 A/G cg25072359 chr17:41440525 NA 0.52 8.33 0.42 2.24e-15 Menopause (age at onset); CRC cis rs1448094 0.935 rs11117119 chr12:86336432 A/T cg02569458 chr12:86230093 RASSF9 0.38 6.57 0.34 1.99e-10 Major depressive disorder; CRC cis rs13392177 0.672 rs4674270 chr2:219053141 G/T cg00012203 chr2:219082015 ARPC2 -0.49 -7.43 -0.38 9.24e-13 Pyoderma gangrenosum in inflammatory bowel disease; CRC cis rs67311347 1.000 rs1004655 chr3:40490009 G/A cg24209194 chr3:40518798 ZNF619 0.42 5.93 0.31 7.86e-9 Renal cell carcinoma; CRC cis rs2549003 0.933 rs7719499 chr5:131814091 C/G cg21138405 chr5:131827807 IRF1 0.56 10.73 0.51 3.25e-23 Asthma (sex interaction); CRC cis rs561341 0.941 rs2428338 chr17:30299629 T/C cg12193833 chr17:30244370 NA -0.63 -8.23 -0.41 4.38e-15 Hip circumference adjusted for BMI; CRC cis rs11758351 0.866 rs56186759 chr6:26207181 C/T cg08260959 chr6:26240920 HIST1H4F -0.34 -5.66 -0.3 3.31e-8 Gout;Renal underexcretion gout; CRC trans rs7615952 0.932 rs13086087 chr3:125646281 A/C cg21747405 chr11:67723411 NA -0.44 -6.21 -0.32 1.6e-9 Blood pressure (smoking interaction); CRC cis rs6952808 0.531 rs4721441 chr7:2184060 A/G cg21782813 chr7:2030301 MAD1L1 0.44 7.54 0.38 4.76e-13 Bipolar disorder and schizophrenia; CRC cis rs7412746 0.658 rs12090215 chr1:150893660 C/A cg18016565 chr1:150552671 MCL1 0.42 6.02 0.31 4.66e-9 Melanoma; CRC cis rs477692 0.569 rs10764884 chr10:131308370 G/C cg05714579 chr10:131428358 MGMT 0.53 7.71 0.39 1.49e-13 Response to temozolomide; CRC cis rs9527 0.545 rs7894588 chr10:104756030 A/T cg04362960 chr10:104952993 NT5C2 0.58 7.67 0.39 1.97e-13 Arsenic metabolism; CRC cis rs892961 0.932 rs7208671 chr17:75413129 T/C cg05865280 chr17:75406074 SEPT9 0.63 14.51 0.62 3.27e-37 Airflow obstruction; CRC cis rs6952808 0.929 rs1801368 chr7:1976457 C/T cg00106254 chr7:1943704 MAD1L1 -0.47 -6.49 -0.34 3.21e-10 Bipolar disorder and schizophrenia; CRC cis rs2996428 0.536 rs12126653 chr1:3773815 C/G cg13057898 chr1:3703894 LRRC47 0.43 5.83 0.31 1.35e-8 Red cell distribution width; CRC cis rs35110281 0.776 rs62226866 chr21:45024186 T/C cg01579765 chr21:45077557 HSF2BP -0.39 -7.57 -0.39 3.84e-13 Mean corpuscular volume; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg13265914 chr8:21999630 REEP4 0.51 7.58 0.39 3.48e-13 Response to antipsychotic treatment; CRC trans rs1997103 1.000 rs10270618 chr7:55396712 T/A cg20935933 chr6:143382018 AIG1 0.52 6.73 0.35 7.57e-11 QRS interval (sulfonylurea treatment interaction); CRC cis rs9517320 0.515 rs61969456 chr13:99174799 C/G cg20487152 chr13:99095054 FARP1 -0.45 -6.71 -0.35 8.71e-11 Longevity; CRC cis rs9303401 1.000 rs9303401 chr17:56847945 C/T cg10487724 chr17:56770010 TEX14;RAD51C 0.56 8.2 0.41 5.52e-15 Cognitive test performance; CRC cis rs1707322 0.963 rs12076580 chr1:46258159 G/A cg03146154 chr1:46216737 IPP 0.61 8.53 0.43 5.32e-16 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs7618501 0.735 rs9876508 chr3:49780844 G/A cg24308560 chr3:49941425 MST1R 0.45 7.01 0.36 1.32e-11 Intelligence (multi-trait analysis); CRC cis rs7512552 0.839 rs12045304 chr1:150399818 G/A cg15654264 chr1:150340011 RPRD2 0.6 8.58 0.43 3.83e-16 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); CRC cis rs651907 0.535 rs13094911 chr3:101519021 T/C cg12386194 chr3:101231763 SENP7 0.52 7.45 0.38 8.46e-13 Colorectal cancer; CRC cis rs2346177 0.542 rs1900591 chr2:46697968 C/T cg26688816 chr2:46740690 ATP6V1E2 -0.62 -9.35 -0.46 1.39e-18 HDL cholesterol; CRC cis rs897984 0.609 rs57576577 chr16:31036367 G/A cg02466173 chr16:30829666 NA -0.65 -9.98 -0.48 1.2e-20 Dementia with Lewy bodies; CRC cis rs6665290 0.582 rs72764213 chr1:227207391 C/T cg10327440 chr1:227177885 CDC42BPA -0.96 -18.43 -0.71 1.31e-52 Myeloid white cell count; CRC cis rs9969804 0.905 rs1111047 chr9:95397418 C/G cg14631576 chr9:95140430 CENPP -0.32 -5.85 -0.31 1.19e-8 Height; CRC trans rs12478296 0.901 rs59191623 chr2:243028595 G/A cg18288967 chr1:45987694 PRDX1 0.66 7.7 0.39 1.64e-13 Obesity-related traits; CRC cis rs9291683 0.632 rs13137074 chr4:10042842 C/T cg11266682 chr4:10021025 SLC2A9 0.53 11.09 0.52 1.76e-24 Bone mineral density; CRC cis rs4642101 0.662 rs9840766 chr3:12821870 G/A cg24848339 chr3:12840334 CAND2 0.31 5.7 0.3 2.7e-8 QRS complex (12-leadsum); CRC cis rs769267 0.930 rs7254927 chr19:19404786 C/G cg20644253 chr19:19431407 KIAA0892;SF4 0.42 5.88 0.31 1.01e-8 Tonsillectomy; CRC cis rs6500395 1.000 rs2080508 chr16:48690665 G/C cg04672837 chr16:48644449 N4BP1 -0.45 -6.62 -0.34 1.47e-10 Response to tocilizumab in rheumatoid arthritis; CRC cis rs9467711 0.606 rs2072803 chr6:26392515 G/C cg16898833 chr6:26189333 HIST1H4D 0.97 7.92 0.4 3.81e-14 Autism spectrum disorder or schizophrenia; CRC cis rs77861329 0.748 rs731684 chr3:52109841 T/C cg08692210 chr3:52188851 WDR51A 0.51 5.77 0.3 1.85e-8 Macrophage inflammatory protein 1b levels; CRC cis rs6445967 0.689 rs11714574 chr3:58380465 A/T cg23715586 chr3:58305044 RPP14 0.34 6.12 0.32 2.64e-9 Platelet count; CRC cis rs4555082 0.874 rs2245329 chr14:105719181 T/C cg06808227 chr14:105710500 BRF1 -0.63 -9.31 -0.46 1.84e-18 Mean platelet volume;Platelet distribution width; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg04799181 chr3:46037014 FYCO1 0.45 6.15 0.32 2.19e-9 Response to antipsychotic treatment; CRC cis rs1799949 0.930 rs33968979 chr17:41297992 G/T cg23758822 chr17:41437982 NA 0.79 13.45 0.6 3.6e-33 Menopause (age at onset); CRC cis rs881375 0.967 rs2270231 chr9:123650982 C/G cg09586646 chr9:123605570 PSMD5;LOC253039 0.53 7.17 0.37 5.09e-12 Rheumatoid arthritis; CRC cis rs11123170 0.529 rs112692022 chr2:113970182 C/T cg11763394 chr2:113992921 PAX8;LOC440839;LOC654433 0.49 5.85 0.31 1.16e-8 Renal function-related traits (BUN); CRC cis rs2204008 0.818 rs1589389 chr12:38416041 G/A cg13010199 chr12:38710504 ALG10B -0.46 -6.52 -0.34 2.64e-10 Bladder cancer; CRC cis rs12760731 0.720 rs10798607 chr1:178373110 C/T cg00404053 chr1:178313656 RASAL2 1.16 11.74 0.54 8.13e-27 Obesity-related traits; CRC cis rs9910055 0.747 rs2905981 chr17:42238625 C/T cg10896456 chr17:42255109 ASB16;C17orf65 0.45 7.37 0.38 1.43e-12 Total body bone mineral density; CRC cis rs2739330 0.796 rs1006771 chr22:24314006 G/T cg04234412 chr22:24373322 LOC391322 -0.57 -8.87 -0.44 4.74e-17 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs7072216 0.555 rs2296433 chr10:100184062 C/A cg26618903 chr10:100175079 PYROXD2 -0.49 -7.34 -0.38 1.67e-12 Metabolite levels; CRC cis rs2976388 0.590 rs10110970 chr8:143820410 G/C cg24634471 chr8:143751801 JRK -0.45 -6.38 -0.33 5.86e-10 Urinary tract infection frequency; CRC cis rs4150161 0.591 rs1056616 chr16:84211718 C/T cg10106505 chr16:84220380 TAF1C -0.66 -6.61 -0.34 1.56e-10 Systolic blood pressure response to hydrochlorothiazide in hypertension; CRC cis rs9381040 0.655 rs2268190 chr6:41030226 C/T cg04346459 chr6:41068666 NFYA;LOC221442 -0.42 -6.28 -0.33 1.09e-9 Alzheimer's disease (late onset); CRC cis rs7552404 0.961 rs448710 chr1:76116554 T/C cg10523679 chr1:76189770 ACADM -0.84 -11.5 -0.54 6.02e-26 Blood metabolite levels;Acylcarnitine levels; CRC cis rs1348850 0.519 rs1527406 chr2:178525655 C/T cg22681709 chr2:178499509 PDE11A -0.41 -7.49 -0.38 6.57e-13 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs35123781 1.000 rs2336880 chr5:139063728 A/G cg10513866 chr5:139070639 NA -0.44 -7.13 -0.37 6.36e-12 Schizophrenia; CRC cis rs9747201 1.000 rs58119191 chr17:80155329 T/C cg14673194 chr17:80132900 CCDC57 -0.5 -6.59 -0.34 1.7e-10 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs4900538 0.855 rs12590993 chr14:102844064 A/G cg18135206 chr14:102964638 TECPR2 -0.99 -17.95 -0.7 1.05e-50 Mean corpuscular volume;Mean corpuscular hemoglobin; CRC cis rs3018066 0.748 rs12509366 chr4:107003343 A/G cg01869342 chr4:106983673 TBCK 0.46 6.79 0.35 5.15e-11 Cancer; CRC cis rs1619661 0.591 rs605414 chr10:44744110 C/T cg09554077 chr10:44749378 NA 0.83 10.78 0.51 2.11e-23 QT interval (ambient particulate matter interaction); CRC trans rs10411161 0.702 rs7251755 chr19:52388948 G/A cg22319618 chr22:45562946 NUP50 -0.65 -7.22 -0.37 3.63e-12 Breast cancer; CRC cis rs7584330 0.740 rs12471291 chr2:238441751 T/G cg16989719 chr2:238392110 NA -0.4 -7.86 -0.4 5.57e-14 Prostate cancer; CRC cis rs561341 1.000 rs8069199 chr17:30281845 A/G cg00745463 chr17:30367425 LRRC37B -0.75 -9.09 -0.45 9.8e-18 Hip circumference adjusted for BMI; CRC cis rs7683537 0.501 rs2171838 chr4:185667404 A/G cg04058563 chr4:185651563 MLF1IP -0.48 -5.93 -0.31 7.63e-9 Systemic lupus erythematosus; CRC cis rs1005277 0.603 rs1998062 chr10:38457652 G/C cg17219203 chr10:38645113 HSD17B7P2 -0.4 -5.65 -0.3 3.39e-8 Extrinsic epigenetic age acceleration; CRC cis rs7772486 0.686 rs1292337 chr6:145967807 A/G cg13319975 chr6:146136371 FBXO30 0.43 6.39 0.33 5.68e-10 Lobe attachment (rater-scored or self-reported); CRC cis rs6534441 0.727 rs56149912 chr4:125440131 G/A cg21609808 chr4:125404261 NA 0.39 5.63 0.3 3.77e-8 Major depressive disorder; CRC cis rs6752107 0.936 rs1045100 chr2:234203597 T/C cg07618928 chr2:234183455 ATG16L1;SCARNA5 0.59 9.79 0.47 5.06e-20 Crohn's disease;Inflammatory bowel disease; CRC cis rs11764590 0.694 rs3996323 chr7:2079428 G/T cg23422044 chr7:1970798 MAD1L1 -0.44 -6.22 -0.32 1.55e-9 Neuroticism; CRC cis rs2404602 0.618 rs12442266 chr15:76567142 T/C cg23625390 chr15:77176239 SCAPER 0.4 5.94 0.31 7.34e-9 Blood metabolite levels; CRC cis rs274567 0.602 rs272853 chr5:131688561 A/G cg04518342 chr5:131593106 PDLIM4 0.41 6.88 0.35 3.03e-11 Blood metabolite levels; CRC cis rs727505 0.607 rs67673811 chr7:124802694 C/G cg23710748 chr7:124431027 NA -0.63 -10.25 -0.49 1.4e-21 Lewy body disease; CRC cis rs6684514 1.000 rs2277870 chr1:156246792 C/T cg16558208 chr1:156270281 VHLL 0.58 9.08 0.45 1.03e-17 Mean corpuscular hemoglobin concentration;Glycated hemoglobin levels; CRC cis rs7113874 0.524 rs10769926 chr11:8623674 C/A cg02811074 chr11:8615871 STK33 0.33 5.88 0.31 9.85e-9 Body mass index in physically active individuals;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs2153535 0.580 rs7341383 chr6:8470634 A/C cg07606381 chr6:8435919 SLC35B3 0.68 10.9 0.51 8.26e-24 Motion sickness; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg14599714 chr12:31226825 DDX11 0.43 5.99 0.31 5.63e-9 Response to antipsychotic treatment; CRC cis rs7666738 0.830 rs13112131 chr4:98976784 G/A cg17366294 chr4:99064904 C4orf37 0.44 7.44 0.38 8.98e-13 Colonoscopy-negative controls vs population controls; CRC cis rs6460942 0.591 rs62448727 chr7:12332362 G/C cg20607287 chr7:12443886 VWDE -0.56 -6.15 -0.32 2.21e-9 Coronary artery disease; CRC cis rs28386778 0.863 rs11649912 chr17:61797515 T/A cg06601766 chr17:61851465 DDX42;CCDC47 0.43 5.88 0.31 9.94e-9 Prudent dietary pattern; CRC cis rs1355223 0.552 rs2421743 chr11:34882840 C/T cg24088639 chr11:34937564 PDHX;APIP -0.58 -8.51 -0.42 6.2e-16 Systemic lupus erythematosus and Systemic sclerosis; CRC cis rs7503807 0.515 rs12452916 chr17:78664655 C/T cg00549398 chr17:78725201 RPTOR 0.43 5.61 0.3 4.29e-8 Obesity; CRC cis rs3818285 0.556 rs944966 chr10:111658334 C/G cg00817464 chr10:111662876 XPNPEP1 -0.47 -6.56 -0.34 2.04e-10 Superior crus of antihelix expression; CRC cis rs9584850 0.834 rs745639 chr13:99119279 C/T cg20487152 chr13:99095054 FARP1 0.41 6.08 0.32 3.34e-9 Neuroticism; CRC trans rs916888 0.821 rs199513 chr17:44856932 A/G cg10053473 chr17:62856997 LRRC37A3 0.58 6.84 0.35 3.77e-11 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg07681084 chr7:156685826 LMBR1 0.39 6.0 0.31 5.29e-9 Intelligence (multi-trait analysis); CRC cis rs731174 0.759 rs497705 chr1:38162760 C/G cg06917450 chr1:38156652 C1orf109 -0.51 -7.27 -0.37 2.69e-12 Prostate cancer (SNP x SNP interaction); CRC cis rs6988636 1.000 rs57902736 chr8:124189893 G/A cg27053337 chr8:124217698 FAM83A 0.48 7.1 0.36 7.74e-12 Urinary uromodulin levels; CRC cis rs11971779 1.000 rs75919582 chr7:139054919 G/A cg07862535 chr7:139043722 LUC7L2 1.0 11.4 0.53 1.34e-25 Diisocyanate-induced asthma; CRC cis rs8180040 0.966 rs11719877 chr3:47425473 C/T cg02527881 chr3:46936655 PTH1R -0.39 -7.47 -0.38 7.42e-13 Colorectal cancer; CRC cis rs9796 0.804 rs28688742 chr15:41403638 G/A cg18705301 chr15:41695430 NDUFAF1 -0.41 -6.87 -0.35 3.14e-11 Menopause (age at onset); CRC cis rs17270561 0.609 rs3922842 chr6:25736564 T/C cg17691542 chr6:26056736 HIST1H1C 0.73 9.26 0.45 2.71e-18 Iron status biomarkers; CRC cis rs7572644 0.509 rs13001060 chr2:28025061 T/C cg27432699 chr2:27873401 GPN1 0.45 5.73 0.3 2.24e-8 Response to carboplatin and paclitaxel in ovarian cancer (Caspase 3/7 EC50); CRC cis rs3768617 0.811 rs61808068 chr1:182979377 T/A ch.1.3577855R chr1:183094577 LAMC1 0.61 8.98 0.44 2.15e-17 Fuchs's corneal dystrophy; CRC trans rs1455244 0.700 rs7229302 chr18:11508904 G/T cg25111554 chr5:74348903 NA 0.4 6.54 0.34 2.34e-10 Schizophrenia; CRC cis rs12802200 0.561 rs7937217 chr11:571967 T/C cg01842473 chr11:617407 IRF7;MUPCDH -0.49 -6.48 -0.34 3.42e-10 Systemic lupus erythematosus; CRC cis rs9467711 0.591 rs13220488 chr6:25896907 A/G cg16898833 chr6:26189333 HIST1H4D 0.87 7.3 0.37 2.2e-12 Autism spectrum disorder or schizophrenia; CRC cis rs7647973 0.696 rs3087866 chr3:49054692 A/G cg07636037 chr3:49044803 WDR6 0.86 10.37 0.5 5.69e-22 Menarche (age at onset); CRC trans rs1346081 0.786 rs1425645 chr4:68028175 C/T cg04493422 chr21:48055366 PRMT2 0.5 6.01 0.31 5.05e-9 Intelligence (multi-trait analysis); CRC cis rs4728302 0.869 rs6969899 chr7:133597490 A/G cg03336402 chr7:133662267 EXOC4 -0.44 -6.42 -0.33 4.78e-10 Intelligence;Intelligence (multi-trait analysis); CRC cis rs2180341 1.000 rs6937287 chr6:127645719 T/A cg27446573 chr6:127587934 RNF146 0.99 14.36 0.62 1.17e-36 Breast cancer; CRC cis rs7927771 0.826 rs2293578 chr11:47437403 C/T cg20307385 chr11:47447363 PSMC3 -0.6 -8.61 -0.43 3.1e-16 Subjective well-being; CRC cis rs9611565 0.568 rs2413656 chr22:42129357 G/T cg03806693 chr22:41940476 POLR3H 0.67 9.5 0.46 4.55e-19 Vitiligo; CRC cis rs9549367 0.636 rs486407 chr13:113833499 G/A cg18105134 chr13:113819100 PROZ 0.85 13.44 0.6 3.84e-33 Platelet distribution width; CRC trans rs9388451 0.807 rs1268070 chr6:126041164 A/G cg05039488 chr6:79577232 IRAK1BP1 -0.54 -8.06 -0.41 1.44e-14 Brugada syndrome; CRC cis rs875971 0.862 rs1695820 chr7:65844563 G/A cg12463550 chr7:65579703 CRCP 0.5 6.98 0.36 1.65e-11 Aortic root size; CRC cis rs561341 0.783 rs512698 chr17:30292507 G/T cg00745463 chr17:30367425 LRRC37B -0.9 -9.89 -0.48 2.27e-20 Hip circumference adjusted for BMI; CRC cis rs904251 0.686 rs2776911 chr6:37439950 T/A cg25019722 chr6:37503610 NA -0.42 -6.09 -0.32 3.12e-9 Cognitive performance; CRC cis rs9814567 1.000 rs6439484 chr3:134249899 A/G cg06541857 chr3:134203789 ANAPC13;CEP63 -0.41 -6.14 -0.32 2.42e-9 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs6933660 0.800 rs13201167 chr6:151773504 T/C cg14416726 chr6:151773293 C6orf211;RMND1 -0.64 -10.01 -0.48 9.09e-21 Menarche (age at onset); CRC cis rs6460942 0.915 rs62448594 chr7:12442229 C/G cg06484146 chr7:12443880 VWDE -0.81 -8.56 -0.43 4.49e-16 Coronary artery disease; CRC cis rs2019137 0.560 rs11123172 chr2:113984303 C/T cg12889195 chr2:113992843 PAX8;LOC440839;LOC654433 -0.64 -10.04 -0.48 7.15e-21 Lymphocyte counts; CRC cis rs9733 0.596 rs3087960 chr1:150620569 C/G cg10589385 chr1:150898437 SETDB1 0.28 5.97 0.31 6.08e-9 Tonsillectomy; CRC cis rs11098499 0.675 rs11098534 chr4:120556772 T/G cg09307838 chr4:120376055 NA 0.62 9.5 0.46 4.43e-19 Corneal astigmatism; CRC trans rs6544773 0.529 rs341588 chr2:45047870 T/C cg10208897 chr5:178548229 ADAMTS2 0.34 6.07 0.32 3.62e-9 Mosquito bite size; CRC trans rs1005277 0.540 rs289638 chr10:37923731 G/A cg17830980 chr10:43048298 ZNF37B -0.44 -6.95 -0.36 1.91e-11 Extrinsic epigenetic age acceleration; CRC cis rs17376456 0.877 rs2085960 chr5:93399934 A/G cg21475434 chr5:93447410 FAM172A 0.74 7.56 0.38 4.17e-13 Diabetic retinopathy; CRC cis rs76419734 0.510 rs12511885 chr4:106662118 G/A cg24545054 chr4:106630052 GSTCD;INTS12 0.61 7.51 0.38 5.72e-13 Post bronchodilator FEV1; CRC trans rs459571 0.635 rs379471 chr9:136890649 G/A cg09836344 chr4:1243392 C4orf42;CTBP1 -0.81 -11.36 -0.53 1.89e-25 Platelet distribution width; CRC cis rs57221529 0.766 rs56278696 chr5:582669 A/G cg09021430 chr5:549028 NA -0.72 -7.85 -0.4 5.75e-14 Lung disease severity in cystic fibrosis; CRC cis rs13191362 1.000 rs73016459 chr6:163066323 C/A cg06582575 chr6:163149167 PACRG;PARK2 0.93 11.9 0.55 2.04e-27 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs875971 0.862 rs778720 chr7:65846275 A/C cg00343986 chr7:65444356 GUSB -0.42 -6.07 -0.32 3.51e-9 Aortic root size; CRC cis rs6545883 0.965 rs766447 chr2:61735569 C/T cg15711740 chr2:61764176 XPO1 -0.52 -7.17 -0.37 4.83e-12 Tuberculosis; CRC cis rs7584330 0.826 rs72620824 chr2:238381083 G/A cg16989719 chr2:238392110 NA -0.46 -7.88 -0.4 4.73e-14 Prostate cancer; CRC cis rs694739 0.628 rs617051 chr11:64133638 C/A cg02228329 chr11:64053129 BAD;GPR137 0.49 6.68 0.35 1.04e-10 Alopecia areata;Crohn's disease;Psoriasis vulgaris; CRC cis rs6840360 0.571 rs62327270 chr4:152533618 C/T cg09659197 chr4:152720779 NA 0.31 5.66 0.3 3.23e-8 Intelligence (multi-trait analysis); CRC cis rs3785574 0.962 rs2584633 chr17:61879501 T/C cg11494091 chr17:61959527 GH2 0.38 5.95 0.31 6.73e-9 Height; CRC cis rs10504229 0.683 rs56192850 chr8:58135356 A/G cg22535103 chr8:58192502 C8orf71 -0.7 -9.34 -0.46 1.47e-18 Developmental language disorder (linguistic errors); CRC cis rs1046896 0.739 rs2379358 chr17:80741612 G/A cg17346650 chr17:80929145 B3GNTL1 0.39 5.82 0.31 1.42e-8 Glycated hemoglobin levels; CRC cis rs17376456 0.877 rs10055741 chr5:93297187 C/T cg25358565 chr5:93447407 FAM172A 1.06 10.59 0.5 9.22e-23 Diabetic retinopathy; CRC cis rs514406 0.644 rs928451 chr1:53195800 A/G cg08859206 chr1:53392774 SCP2 0.42 6.51 0.34 2.76e-10 Monocyte count; CRC cis rs9467773 0.595 rs2172007 chr6:26639777 A/C cg09904177 chr6:26538194 HMGN4 0.64 9.39 0.46 1.01e-18 Intelligence (multi-trait analysis); CRC cis rs881375 0.967 rs1860824 chr9:123659339 G/T cg09419670 chr9:123605666 PSMD5;LOC253039 0.6 8.83 0.44 6.45e-17 Rheumatoid arthritis; CRC trans rs2303319 0.504 rs12470743 chr2:162611202 G/A cg11326919 chr17:43324904 LOC100133991 -0.64 -5.97 -0.31 5.99e-9 Cognitive function; CRC cis rs7918232 0.825 rs4749233 chr10:27467967 G/A cg14442939 chr10:27389572 ANKRD26 0.82 9.11 0.45 8.01e-18 Breast cancer; CRC trans rs3733585 0.638 rs6449155 chr4:9956547 T/G cg26043149 chr18:55253948 FECH -0.5 -7.65 -0.39 2.23e-13 Cleft plate (environmental tobacco smoke interaction); CRC cis rs769267 0.965 rs8103496 chr19:19386015 A/G cg03709012 chr19:19516395 GATAD2A 0.72 10.98 0.52 4.29e-24 Tonsillectomy; CRC cis rs5753618 0.539 rs5997933 chr22:31672752 A/C cg07713946 chr22:31675144 LIMK2 -0.39 -5.62 -0.3 4.12e-8 Colorectal cancer; CRC cis rs11098499 0.789 rs9991166 chr4:120237851 G/A cg24375607 chr4:120327624 NA 0.48 7.64 0.39 2.32e-13 Corneal astigmatism; CRC cis rs4689388 0.926 rs10937718 chr4:6295217 T/C cg14416269 chr4:6271139 WFS1 0.4 6.59 0.34 1.72e-10 Type 2 diabetes and other traits;Type 2 diabetes; CRC cis rs798554 0.759 rs1636255 chr7:2892804 A/C cg09658497 chr7:2847517 GNA12 0.41 5.65 0.3 3.48e-8 Height; CRC cis rs11190604 0.767 rs10509743 chr10:102190406 C/T cg16342193 chr10:102329863 NA -0.37 -6.0 -0.31 5.3300000000000004e-09 Palmitoleic acid (16:1n-7) levels; CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg06745235 chr1:180471494 ACBD6 -0.5 -6.0 -0.31 5.25e-9 Diisocyanate-induced asthma; CRC cis rs11711311 0.911 rs28577577 chr3:113447276 A/G cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.52 -7.0 -0.36 1.47e-11 IgG glycosylation; CRC cis rs1005277 0.579 rs2008449 chr10:38414204 A/T cg00409905 chr10:38381863 ZNF37A 0.66 11.27 0.53 3.8e-25 Extrinsic epigenetic age acceleration; CRC cis rs7618915 0.501 rs2164885 chr3:52731269 T/C cg05573699 chr3:52720067 GNL3;PBRM1 -0.48 -7.0 -0.36 1.47e-11 Bipolar disorder; CRC cis rs4803455 0.565 rs11670143 chr19:41864971 A/G cg09537434 chr19:41945824 ATP5SL -0.57 -8.44 -0.42 1.01e-15 Migraine;Coronary artery disease; CRC cis rs8180040 0.764 rs2132173 chr3:47247060 C/T cg02527881 chr3:46936655 PTH1R 0.39 7.41 0.38 1.08e-12 Colorectal cancer; CRC cis rs6061231 0.793 rs6061512 chr20:60976929 G/A cg22601191 chr20:60968625 CABLES2 0.54 8.83 0.44 6.51e-17 Colorectal cancer; CRC cis rs7731657 0.537 rs10066004 chr5:130304689 G/A cg08523029 chr5:130500466 HINT1 -0.48 -6.15 -0.32 2.2e-9 Fasting plasma glucose; CRC cis rs4319547 0.956 rs9988963 chr12:122991478 C/G cg05707623 chr12:122985044 ZCCHC8 -0.74 -9.34 -0.46 1.45e-18 Body mass index; CRC cis rs1401999 0.714 rs7646621 chr3:183640865 A/C cg01324343 chr3:183735012 ABCC5 -0.6 -9.69 -0.47 1.03e-19 Anterior chamber depth; CRC cis rs1552244 0.882 rs13062917 chr3:10017032 T/A cg16606324 chr3:10149918 C3orf24 0.61 7.98 0.4 2.47e-14 Alzheimer's disease; CRC cis rs7224685 0.501 rs781839 chr17:3961489 C/T cg21851534 chr17:3907994 ZZEF1 0.36 6.34 0.33 7.65e-10 Type 2 diabetes; CRC cis rs1005277 0.683 rs7923868 chr10:37989766 T/C cg25427524 chr10:38739819 LOC399744 -0.72 -12.44 -0.57 2.25e-29 Extrinsic epigenetic age acceleration; CRC trans rs1814175 0.607 rs11493324 chr11:50011304 T/C cg21153622 chr11:89784906 NA -0.43 -7.04 -0.36 1.15e-11 Height; CRC trans rs11098499 0.820 rs6534140 chr4:120455311 C/T cg25214090 chr10:38739885 LOC399744 0.65 10.07 0.49 5.96e-21 Corneal astigmatism; CRC cis rs6748734 1.000 rs7604393 chr2:241825034 T/G cg07537917 chr2:241836409 C2orf54 -0.22 -6.17 -0.32 2.05e-9 Urinary metabolites; CRC cis rs3204270 0.639 rs6565620 chr17:79658100 C/T cg09655341 chr17:79618100 PDE6G 0.54 6.56 0.34 2.05e-10 Dental caries; CRC trans rs1814175 0.817 rs4881648 chr11:49812901 A/G cg03929089 chr4:120376271 NA -0.96 -18.51 -0.71 6.54e-53 Height; CRC cis rs6121246 0.528 rs6060252 chr20:30191084 A/G cg13852791 chr20:30311386 BCL2L1 0.6 8.21 0.41 5.04e-15 Mean corpuscular hemoglobin; CRC cis rs10504229 0.683 rs1495865 chr8:58141160 T/G cg02725872 chr8:58115012 NA -0.64 -11.55 -0.54 3.85e-26 Developmental language disorder (linguistic errors); CRC cis rs4363385 0.818 rs6661791 chr1:152994113 G/A cg25856811 chr1:152973957 SPRR3 -0.24 -6.71 -0.35 8.61e-11 Inflammatory skin disease; CRC cis rs9911578 1.000 rs8067571 chr17:56868856 C/T cg12560992 chr17:57184187 TRIM37 0.9 16.6 0.68 2.13e-45 Intelligence (multi-trait analysis); CRC cis rs11628318 0.853 rs10151896 chr14:103039936 G/C cg12046867 chr14:103022105 NA -0.82 -11.79 -0.55 5.13e-27 Platelet count; CRC cis rs13191362 1.000 rs2156257 chr6:163100710 G/T cg21926612 chr6:163149169 PACRG;PARK2 0.98 12.74 0.57 1.73e-30 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC trans rs62103177 0.810 rs62103189 chr18:77627815 G/A cg05926928 chr17:57297772 GDPD1 1.06 9.98 0.48 1.12e-20 Opioid sensitivity; CRC cis rs9463078 0.774 rs9296457 chr6:45264687 A/G cg25276700 chr6:44698697 NA -0.28 -6.72 -0.35 8.12e-11 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; CRC cis rs1799949 0.894 rs8176160 chr17:41241503 T/C cg01879757 chr17:41196368 BRCA1 -0.42 -6.33 -0.33 7.99e-10 Menopause (age at onset); CRC cis rs798554 0.679 rs2644300 chr7:2883071 G/A cg19346786 chr7:2764209 NA -0.36 -6.25 -0.33 1.25e-9 Height; CRC cis rs2075371 0.933 rs1421480 chr7:133958114 A/C cg02659138 chr7:134003124 SLC35B4 0.36 6.24 0.33 1.33e-9 Mean platelet volume; CRC cis rs7394190 0.748 rs11541237 chr10:75530962 C/T cg07699608 chr10:75541558 CHCHD1 0.61 6.37 0.33 6.53e-10 Incident atrial fibrillation; CRC cis rs6460942 0.915 rs1595800 chr7:12439816 G/A cg20607287 chr7:12443886 VWDE -0.68 -7.33 -0.37 1.84e-12 Coronary artery disease; CRC cis rs4713118 0.513 rs149945 chr6:28002853 T/C cg12172441 chr6:28176163 NA 0.52 7.34 0.38 1.64e-12 Parkinson's disease; CRC cis rs2227564 0.533 rs3870402 chr10:75473787 A/C cg16540259 chr10:75572220 NDST2 0.52 7.65 0.39 2.22e-13 Crohn's disease;Inflammatory bowel disease; CRC cis rs7300001 0.504 rs12318462 chr12:110504717 C/A cg12870014 chr12:110450643 ANKRD13A 0.89 7.48 0.38 6.96e-13 Headache; CRC cis rs8072100 0.967 rs11079784 chr17:45702280 A/G cg08085267 chr17:45401833 C17orf57 0.65 10.13 0.49 3.5e-21 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs4629710 0.592 rs11154622 chr6:131547578 C/T cg12606694 chr6:131520996 AKAP7 0.56 8.39 0.42 1.41e-15 Multiple myeloma (IgH translocation); CRC cis rs9926296 0.605 rs886952 chr16:89836781 G/A cg04287289 chr16:89883240 FANCA 0.81 14.44 0.62 5.85e-37 Vitiligo; CRC cis rs4731207 0.596 rs1013754 chr7:124642047 T/C cg23710748 chr7:124431027 NA -0.38 -6.08 -0.32 3.27e-9 Cutaneous malignant melanoma; CRC cis rs16867335 1.000 rs16867335 chr2:181458934 C/T cg23363182 chr2:181467187 NA -0.49 -6.62 -0.34 1.45e-10 Survival in rectal cancer; CRC cis rs9549328 0.700 rs3011474 chr13:113617865 T/C cg08614441 chr13:113633676 MCF2L 0.4 7.04 0.36 1.13e-11 Systolic blood pressure; CRC trans rs8002861 0.619 rs9567289 chr13:44437104 C/T cg12856521 chr11:46389249 DGKZ 0.44 7.26 0.37 2.78e-12 Leprosy; CRC trans rs11654801 0.947 rs11656662 chr17:20921837 G/C cg23759823 chr7:139672531 TBXAS1 -0.45 -6.42 -0.33 4.71e-10 Mosquito bite size; CRC cis rs3741404 0.560 rs17699798 chr11:63898806 C/G cg05016508 chr11:63871570 FLRT1;MACROD1 -0.37 -5.77 -0.3 1.87e-8 Platelet count; CRC cis rs1153858 1.000 rs1980288 chr15:45620612 T/C cg21132104 chr15:45694354 SPATA5L1 0.58 8.35 0.42 1.89e-15 Homoarginine levels; CRC cis rs9398803 0.965 rs17754780 chr6:126664333 C/T cg19875578 chr6:126661172 C6orf173 0.4 5.63 0.3 3.94e-8 Male-pattern baldness; CRC cis rs17376456 0.690 rs6892055 chr5:93113023 A/T cg21475434 chr5:93447410 FAM172A 0.64 6.33 0.33 7.87e-10 Diabetic retinopathy; CRC cis rs4713118 0.629 rs203887 chr6:28021269 C/T cg12273811 chr6:28175739 NA 0.58 7.29 0.37 2.36e-12 Parkinson's disease; CRC cis rs826838 0.967 rs73096706 chr12:38860563 G/A cg13010199 chr12:38710504 ALG10B 0.49 6.28 0.33 1.05e-9 Heart rate; CRC cis rs6502050 0.871 rs62079994 chr17:80076516 T/C cg25804541 chr17:80189381 SLC16A3 0.32 6.13 0.32 2.51e-9 Life satisfaction; CRC cis rs12325245 0.536 rs34737210 chr16:58549262 T/C cg02549819 chr16:58548995 SETD6 1.29 8.25 0.41 3.97e-15 Schizophrenia; CRC cis rs6502050 0.799 rs58538819 chr17:80107153 G/C cg02741985 chr17:80059408 CCDC57 0.44 7.03 0.36 1.17e-11 Life satisfaction; CRC cis rs5769765 0.955 rs9616394 chr22:50314927 G/C cg26441486 chr22:50317300 CRELD2 0.33 5.67 0.3 3.18e-8 Schizophrenia; CRC cis rs7249142 0.562 rs10418053 chr19:19287164 A/G cg26504305 chr19:19281019 LOC729991-MEF2B;MEF2B -0.41 -8.07 -0.41 1.33e-14 IgG glycosylation; CRC cis rs10883723 0.773 rs7917402 chr10:104246690 C/T cg22532475 chr10:104410764 TRIM8 -0.36 -6.66 -0.34 1.18e-10 Allergic disease (asthma, hay fever or eczema); CRC cis rs422249 0.512 rs174568 chr11:61593816 C/T cg00603274 chr11:61596626 FADS2 -0.43 -6.3 -0.33 9.63e-10 Trans fatty acid levels; CRC trans rs12599106 0.839 rs3853177 chr16:34498532 A/G cg01171360 chr6:293285 DUSP22 -0.47 -6.66 -0.34 1.16e-10 Menopause (age at onset); CRC cis rs17376456 0.825 rs28412976 chr5:93248377 T/C cg25358565 chr5:93447407 FAM172A 1.12 10.36 0.5 5.96e-22 Diabetic retinopathy; CRC cis rs9311474 0.607 rs4687625 chr3:52563718 C/T cg10802521 chr3:52805072 NEK4 -0.53 -8.33 -0.42 2.28e-15 Electroencephalogram traits; CRC cis rs11212617 1.000 rs11212579 chr11:108150664 A/T cg01991180 chr11:108092276 ATM;NPAT 0.42 6.14 0.32 2.42e-9 Response to metformin in type 2 diabetes (glycemic); CRC cis rs40363 0.723 rs2379831 chr16:3538927 T/C cg21433313 chr16:3507492 NAT15 -0.66 -6.2 -0.32 1.68e-9 Tuberculosis; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg00301775 chr5:40798454 PRKAA1 -0.43 -6.5 -0.34 2.94e-10 Liver disease severity in Alagille syndrome; CRC cis rs10540 1.000 rs10540 chr11:494662 G/A cg03576123 chr11:487126 PTDSS2 -1.04 -10.79 -0.51 1.91e-23 Body mass index; CRC cis rs12325245 0.536 rs17821549 chr16:58554780 C/T cg19824325 chr16:58548873 SETD6 0.98 6.47 0.34 3.47e-10 Schizophrenia; CRC cis rs11676348 0.811 rs4674255 chr2:218987325 C/T cg00012203 chr2:219082015 ARPC2 -0.43 -6.43 -0.33 4.49e-10 Ulcerative colitis; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg04616222 chr10:99078965 FRAT1 0.44 5.97 0.31 6.31e-9 Anxiety disorder; CRC cis rs10871290 1.000 rs10871290 chr16:74472696 C/T cg01733217 chr16:74700730 RFWD3 -0.65 -10.3 -0.49 9.19e-22 Breast cancer; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg22066877 chr1:160175701 PEA15 0.43 6.29 0.33 9.95e-10 Response to antipsychotic treatment; CRC cis rs853679 0.517 rs4711165 chr6:28115184 T/G cg21251018 chr6:28226885 NKAPL 0.48 6.17 0.32 2.02e-9 Depression; CRC cis rs4481887 0.927 rs9651177 chr1:248445702 A/G cg00666640 chr1:248458726 OR2T12 0.46 8.34 0.42 2.05e-15 Common traits (Other); CRC cis rs9463078 0.653 rs6899378 chr6:45080368 C/T cg25276700 chr6:44698697 NA -0.24 -5.8 -0.3 1.6e-8 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; CRC cis rs6952808 0.693 rs10950413 chr7:1912988 A/G cg14004847 chr7:1930337 MAD1L1 -0.48 -7.09 -0.36 8.36e-12 Bipolar disorder and schizophrenia; CRC cis rs7147624 1.000 rs10083363 chr14:66200768 G/A cg03016385 chr14:66212404 NA -1.03 -10.36 -0.5 5.94e-22 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs801193 1.000 rs2659889 chr7:66217112 A/G cg18876405 chr7:65276391 NA 0.6 10.69 0.51 4.26e-23 Aortic root size; CRC cis rs6964587 0.692 rs2027950 chr7:91863700 C/G cg17063962 chr7:91808500 NA -0.62 -10.29 -0.49 1.01e-21 Breast cancer; CRC cis rs10504229 0.728 rs59266065 chr8:58156236 A/G cg08219700 chr8:58056026 NA 0.45 5.66 0.3 3.37e-8 Developmental language disorder (linguistic errors); CRC trans rs2518564 0.541 rs2814764 chr1:159064568 A/T cg03710481 chr6:122931605 PKIB 0.52 6.11 0.32 2.79e-9 White blood cell count; CRC cis rs1577917 0.958 rs10944144 chr6:86537755 C/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.59 -7.34 -0.38 1.68e-12 Response to antipsychotic treatment; CRC cis rs6570726 0.791 rs6902410 chr6:145905261 G/A cg23711669 chr6:146136114 FBXO30 0.68 11.35 0.53 2.09e-25 Lobe attachment (rater-scored or self-reported); CRC cis rs11123610 0.520 rs7576701 chr2:3718227 T/C cg00999904 chr2:3704751 ALLC -0.53 -6.7 -0.35 9.16e-11 Response to inhaled corticosteroid treatment in asthma (change in FEV1); CRC cis rs9549367 0.826 rs2287249 chr13:113889355 A/G cg18105134 chr13:113819100 PROZ -0.72 -10.84 -0.51 1.32e-23 Platelet distribution width; CRC cis rs11098499 0.954 rs10006706 chr4:120409152 A/G cg09307838 chr4:120376055 NA 0.68 10.49 0.5 2.06e-22 Corneal astigmatism; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg12045430 chr1:29407 WASH5P 0.37 7.28 0.37 2.45e-12 Liver disease severity in Alagille syndrome; CRC cis rs708547 0.836 rs1713997 chr4:57843863 G/C cg25525207 chr4:57843836 C4orf14;POLR2B -0.6 -8.82 -0.44 6.62e-17 Response to bleomycin (chromatid breaks); CRC cis rs10905065 1.000 rs10795488 chr10:5755207 C/A cg11519256 chr10:5708881 ASB13 0.44 6.19 0.32 1.77e-9 Menopause (age at onset); CRC cis rs9611565 0.512 rs2050033 chr22:42159229 G/T cg06481639 chr22:41940642 POLR3H 0.56 6.16 0.32 2.09e-9 Vitiligo; CRC cis rs600806 0.850 rs10858086 chr1:109915075 C/A cg23032129 chr1:109941072 SORT1 -0.27 -5.84 -0.31 1.24e-8 Intelligence (multi-trait analysis); CRC cis rs34779708 0.897 rs4934716 chr10:35369299 A/G cg03585969 chr10:35415529 CREM 0.56 7.47 0.38 7.35e-13 Inflammatory bowel disease;Crohn's disease; CRC cis rs17376456 0.825 rs28705226 chr5:93233135 T/C cg21475434 chr5:93447410 FAM172A 0.79 8.19 0.41 5.73e-15 Diabetic retinopathy; CRC cis rs1707322 0.721 rs10890343 chr1:46157922 C/T cg06784218 chr1:46089804 CCDC17 0.63 11.7 0.54 1.12e-26 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs4822044 0.560 rs7284839 chr22:42010902 C/T cg06634786 chr22:41940651 POLR3H 0.65 7.08 0.36 8.92e-12 Cannabis dependence symptom count; CRC cis rs12291225 0.535 rs12806025 chr11:14413817 G/A cg05501817 chr11:14380813 RRAS2 -0.42 -5.85 -0.31 1.2e-8 Sense of smell; CRC cis rs35110281 0.591 rs86138 chr21:44932398 G/A cg01579765 chr21:45077557 HSF2BP -0.38 -7.24 -0.37 3.29e-12 Mean corpuscular volume; CRC cis rs28386778 0.897 rs894408 chr17:61896814 C/T cg25654072 chr17:61904446 PSMC5;FTSJ3 0.72 11.25 0.53 4.67e-25 Prudent dietary pattern; CRC cis rs9649213 0.593 rs12704989 chr7:98029438 G/T cg21770322 chr7:97807741 LMTK2 0.52 8.48 0.42 7.61e-16 Prostate cancer (SNP x SNP interaction); CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg03432641 chr12:49760606 SPATS2 0.44 6.1 0.32 2.91e-9 Anxiety disorder; CRC cis rs9303401 0.659 rs3809724 chr17:57061238 G/A cg10487724 chr17:56770010 TEX14;RAD51C 0.8 9.22 0.45 3.69e-18 Cognitive test performance; CRC cis rs6701037 0.512 rs4650716 chr1:175128711 C/A cg00321850 chr1:175162397 KIAA0040 0.44 7.54 0.38 4.6e-13 Alcohol dependence; CRC cis rs11105298 0.891 rs6538189 chr12:89885923 C/A cg08166232 chr12:89918718 WDR51B;GALNT4 -0.61 -7.81 -0.4 7.9e-14 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; CRC cis rs1129187 1.000 rs1129187 chr6:42932200 G/T cg09436375 chr6:42928200 GNMT -0.31 -5.75 -0.3 2.01e-8 Alzheimer's disease in APOE e4+ carriers; CRC cis rs754466 0.580 rs10430530 chr10:79582812 T/C cg17075019 chr10:79541650 NA -0.96 -17.86 -0.7 2.34e-50 Liver enzyme levels (gamma-glutamyl transferase); CRC trans rs11252926 0.801 rs12358553 chr10:558014 C/T cg00953403 chr17:74099816 EXOC7 -0.46 -6.25 -0.33 1.26e-9 Psychosis in Alzheimer's disease; CRC cis rs2303759 0.709 rs2278405 chr19:49812403 A/C cg24324837 chr19:49891574 CCDC155 -0.52 -6.8 -0.35 4.8e-11 Multiple sclerosis; CRC cis rs9814567 1.000 rs2887797 chr3:134202506 T/G cg06109529 chr3:134205091 CEP63;ANAPC13 -0.83 -12.65 -0.57 3.69e-30 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs8044868 0.586 rs2070937 chr16:72089740 A/G cg23815491 chr16:72088622 HP 0.5 7.33 0.37 1.77e-12 Body mass index (change over time) in cancer or chronic obstructive pulmonary disease;Body mass index (change over time) in cancer; CRC cis rs11212617 1.000 rs599558 chr11:108177538 C/T cg12106634 chr11:108092400 ATM;NPAT 0.42 6.21 0.32 1.59e-9 Response to metformin in type 2 diabetes (glycemic); CRC cis rs6502050 0.769 rs9898292 chr17:80100345 A/T cg09264619 chr17:80180166 NA -0.34 -5.81 -0.3 1.5e-8 Life satisfaction; CRC trans rs931812 0.895 rs13251731 chr8:101902528 C/G cg20993868 chr7:22813445 NA 0.53 9.93 0.48 1.64e-20 Attention deficit hyperactivity disorder and conduct disorder; CRC cis rs7301016 0.846 rs12367878 chr12:63027483 C/T cg11441379 chr12:63026424 NA 0.54 5.67 0.3 3.09e-8 IgG glycosylation; CRC cis rs1799949 0.930 rs3092987 chr17:41222723 T/C cg25072359 chr17:41440525 NA 0.45 6.63 0.34 1.4e-10 Menopause (age at onset); CRC cis rs13108904 0.518 rs4974603 chr4:1343168 C/T cg20092199 chr4:1342459 KIAA1530 0.49 8.22 0.41 4.68e-15 Obesity-related traits; CRC cis rs2033711 0.870 rs11669741 chr19:58960481 C/T cg00825309 chr19:58991885 ZNF446 0.46 6.86 0.35 3.39e-11 Uric acid clearance; CRC cis rs9372498 0.536 rs9489447 chr6:118900846 G/A cg10217327 chr6:118973057 C6orf204 0.52 5.94 0.31 7.42e-9 Diastolic blood pressure; CRC cis rs7618915 0.547 rs11130313 chr3:52676190 A/C cg11645453 chr3:52864694 ITIH4 0.36 6.25 0.33 1.29e-9 Bipolar disorder; CRC cis rs478304 0.651 rs7110576 chr11:65512057 T/G cg27068330 chr11:65405492 SIPA1 -0.63 -9.46 -0.46 5.9e-19 Acne (severe); CRC cis rs67478160 0.625 rs7141473 chr14:104316055 A/C cg08213375 chr14:104286397 PPP1R13B -0.64 -13.26 -0.59 1.86e-32 Schizophrenia; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg03205495 chr19:14640249 TECR;MIR639 0.45 6.11 0.32 2.79e-9 Response to antipsychotic treatment; CRC cis rs2067615 0.524 rs10861645 chr12:107071130 C/T cg15890332 chr12:107067104 RFX4 0.32 5.71 0.3 2.58e-8 Heart rate; CRC cis rs6738825 0.547 rs67616109 chr2:198409490 G/A cg10820045 chr2:198174542 NA 0.34 6.06 0.32 3.83e-9 Crohn's disease; CRC cis rs1784581 0.588 rs1784583 chr6:162410132 C/T cg17173639 chr6:162384350 PARK2 -0.6 -9.69 -0.47 1.09e-19 Itch intensity from mosquito bite; CRC cis rs11077998 0.844 rs12185254 chr17:80498972 C/T cg10255544 chr17:80519551 FOXK2 0.38 5.98 0.31 5.72e-9 Reticulocyte fraction of red cells; CRC cis rs853679 0.550 rs34477097 chr6:28197186 C/T cg21251018 chr6:28226885 NKAPL 0.52 7.36 0.38 1.52e-12 Depression; CRC cis rs35306767 0.714 rs12783621 chr10:1083304 C/T cg20503657 chr10:835505 NA 0.66 8.82 0.44 6.86e-17 Eosinophil percentage of granulocytes; CRC cis rs4561483 0.864 rs190461 chr16:12005745 A/G cg08843971 chr16:11963173 GSPT1 -0.61 -8.79 -0.44 8.67e-17 Testicular germ cell tumor; CRC trans rs8005745 0.505 rs710047 chr14:62118819 C/G cg09325506 chr2:243030735 LOC728323 -0.44 -6.0 -0.31 5.28e-9 Select biomarker traits; CRC cis rs9517320 1.000 rs7996629 chr13:99128037 C/T cg20487152 chr13:99095054 FARP1 0.36 5.93 0.31 7.65e-9 Longevity; CRC cis rs1552244 1.000 rs9820598 chr3:10117912 C/G cg18598329 chr3:10140678 FANCD2;C3orf24 -0.9 -12.84 -0.58 7.52e-31 Alzheimer's disease; CRC cis rs11098499 0.954 rs3733519 chr4:120423448 A/G cg24375607 chr4:120327624 NA 0.51 7.69 0.39 1.75e-13 Corneal astigmatism; CRC trans rs3733585 0.699 rs6449202 chr4:9974043 T/C cg26043149 chr18:55253948 FECH -0.48 -7.48 -0.38 6.96e-13 Cleft plate (environmental tobacco smoke interaction); CRC cis rs3996993 0.597 rs12529923 chr6:52736056 C/T cg20803780 chr6:52668592 GSTA1 0.39 6.61 0.34 1.57e-10 Hemoglobin concentration; CRC cis rs2836974 0.644 rs2836981 chr21:40688365 C/T cg17971929 chr21:40555470 PSMG1 -0.63 -9.28 -0.46 2.33e-18 Cognitive function; CRC trans rs11039798 0.925 rs6485831 chr11:48455031 A/T cg15704280 chr7:45808275 SEPT13 0.65 6.22 0.32 1.49e-9 Axial length; CRC cis rs40363 0.729 rs6501176 chr16:3522197 A/G cg21433313 chr16:3507492 NAT15 -0.58 -6.97 -0.36 1.78e-11 Tuberculosis; CRC cis rs7959452 0.535 rs7135092 chr12:69658330 T/C cg22834771 chr12:69754056 YEATS4 -0.41 -5.9 -0.31 9.25e-9 Blood protein levels; CRC cis rs11676348 0.935 rs13007992 chr2:218964051 G/T cg04731861 chr2:219085781 ARPC2 0.29 6.01 0.31 4.97e-9 Ulcerative colitis; CRC cis rs561341 1.000 rs473356 chr17:30321762 G/C cg23018236 chr17:30244563 NA -0.67 -8.03 -0.4 1.78e-14 Hip circumference adjusted for BMI; CRC cis rs11123610 0.520 rs59726279 chr2:3718655 A/G cg00999904 chr2:3704751 ALLC -0.53 -6.7 -0.35 9.16e-11 Response to inhaled corticosteroid treatment in asthma (change in FEV1); CRC cis rs9916302 0.706 rs4795358 chr17:37573065 A/C cg00129232 chr17:37814104 STARD3 -0.58 -7.18 -0.37 4.56e-12 Glomerular filtration rate (creatinine); CRC cis rs10504229 1.000 rs9650139 chr8:58190508 G/T cg02290350 chr8:58132656 NA -0.42 -5.98 -0.31 5.73e-9 Developmental language disorder (linguistic errors); CRC cis rs909002 0.800 rs3753612 chr1:32082410 C/G cg01639898 chr1:32083012 HCRTR1 0.29 5.93 0.31 7.58e-9 Intelligence (multi-trait analysis); CRC cis rs939584 1.000 rs7559018 chr2:645203 C/T cg03610516 chr2:642275 NA 0.42 5.88 0.31 9.94e-9 Body mass index; CRC cis rs7618915 0.501 rs3852066 chr3:52621839 C/T cg18404041 chr3:52824283 ITIH1 -0.41 -8.61 -0.43 3.02e-16 Bipolar disorder; CRC cis rs4319547 0.794 rs61954972 chr12:123074167 T/G cg05707623 chr12:122985044 ZCCHC8 -0.75 -9.4 -0.46 9.56e-19 Body mass index; CRC cis rs561341 1.000 rs555629 chr17:30294136 T/C cg19193384 chr17:30244184 NA -0.65 -7.48 -0.38 6.75e-13 Hip circumference adjusted for BMI; CRC cis rs6502050 0.835 rs66932937 chr17:80116803 G/A cg09264619 chr17:80180166 NA -0.35 -5.97 -0.31 5.98e-9 Life satisfaction; CRC cis rs6502050 0.835 rs8066284 chr17:80127825 C/T cg09264619 chr17:80180166 NA -0.34 -5.76 -0.3 1.93e-8 Life satisfaction; CRC cis rs1552244 1.000 rs722509 chr3:10102377 T/A cg18598329 chr3:10140678 FANCD2;C3orf24 -0.87 -11.82 -0.55 4.24e-27 Alzheimer's disease; CRC cis rs6502050 0.805 rs9898507 chr17:80119628 C/T cg11859384 chr17:80120422 CCDC57 -0.36 -5.75 -0.3 2.06e-8 Life satisfaction; CRC cis rs736408 0.511 rs12637632 chr3:52708073 A/T cg08222913 chr3:52553049 STAB1 -0.34 -6.24 -0.33 1.36e-9 Bipolar disorder; CRC cis rs453301 0.686 rs6987107 chr8:8893581 A/G cg06636001 chr8:8085503 FLJ10661 -0.47 -7.1 -0.36 7.58e-12 Joint mobility (Beighton score); CRC cis rs3796619 1.000 rs11939380 chr4:1086871 C/T cg11579758 chr4:1086637 RNF212 -0.4 -6.59 -0.34 1.77e-10 Recombination rate (males); CRC cis rs6502050 0.749 rs7406163 chr17:80086389 C/T cg19223190 chr17:80058835 NA -0.39 -6.22 -0.32 1.52e-9 Life satisfaction; CRC cis rs9393777 0.920 rs34150729 chr6:27388754 T/C cg15845792 chr6:28175446 NA 0.89 5.71 0.3 2.56e-8 Intelligence (multi-trait analysis); CRC cis rs9398803 0.865 rs9375441 chr6:126778600 G/A cg19875578 chr6:126661172 C6orf173 0.43 5.87 0.31 1.09e-8 Male-pattern baldness; CRC cis rs11785400 1.000 rs6995314 chr8:143749718 A/G cg24634471 chr8:143751801 JRK -0.47 -6.6 -0.34 1.68e-10 Schizophrenia; CRC cis rs78456975 0.941 rs28913033 chr2:1523194 T/C cg12573674 chr2:1569213 NA -0.74 -7.3 -0.37 2.21e-12 Placebo response in major depressive disorder (% change in symptom score); CRC cis rs2239547 0.657 rs3755803 chr3:52866157 C/G cg11645453 chr3:52864694 ITIH4 0.61 10.87 0.51 1e-23 Schizophrenia; CRC cis rs597539 0.652 rs660614 chr11:68659488 G/A cg21963583 chr11:68658836 MRPL21 0.63 11.52 0.54 5.02e-26 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC trans rs1455244 0.700 rs7229302 chr18:11508904 G/T cg17914881 chr12:121838395 RNF34 0.42 6.44 0.33 4.32e-10 Schizophrenia; CRC cis rs10924970 0.649 rs4659492 chr1:235482207 T/G cg09010748 chr1:235293032 TOMM20 -0.4 -5.65 -0.3 3.57e-8 Asthma; CRC cis rs6662572 0.737 rs75490316 chr1:46553785 G/A cg03123370 chr1:45965343 CCDC163P;MMACHC 0.47 5.96 0.31 6.59e-9 Blood protein levels; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg23508591 chr15:75871807 PTPN9 0.42 6.85 0.35 3.59e-11 Liver disease severity in Alagille syndrome; CRC cis rs9325144 0.600 rs10880934 chr12:38730455 C/T cg26384229 chr12:38710491 ALG10B -0.57 -8.31 -0.42 2.53e-15 Morning vs. evening chronotype; CRC cis rs6952808 1.000 rs6953693 chr7:1886388 C/G cg02951883 chr7:2050386 MAD1L1 -0.65 -10.39 -0.5 4.64e-22 Bipolar disorder and schizophrenia; CRC cis rs672059 1.000 rs660602 chr1:183162774 T/G ch.1.3577855R chr1:183094577 LAMC1 0.48 6.88 0.35 3.1e-11 Hypertriglyceridemia; CRC cis rs6502050 0.835 rs4789676 chr17:80123078 C/T cg25804541 chr17:80189381 SLC16A3 -0.31 -5.95 -0.31 6.84e-9 Life satisfaction; CRC cis rs4660306 0.614 rs1007859 chr1:45911906 C/T cg03123370 chr1:45965343 CCDC163P;MMACHC 0.5 6.64 0.34 1.32e-10 Homocysteine levels; CRC cis rs9488822 0.676 rs4354188 chr6:116327936 T/C cg05304507 chr6:116381966 FRK 0.3 8.24 0.41 4.08e-15 Cholesterol, total;LDL cholesterol; CRC cis rs9768139 0.733 rs13309408 chr7:158122261 C/T cg23298862 chr7:158159286 PTPRN2 0.39 5.99 0.31 5.39e-9 Calcium levels; CRC cis rs2836974 0.545 rs8128901 chr21:40710419 G/A cg11644478 chr21:40555479 PSMG1 0.46 6.69 0.35 9.68e-11 Cognitive function; CRC cis rs801193 0.569 rs2659893 chr7:66199993 G/A cg00343986 chr7:65444356 GUSB 0.44 6.15 0.32 2.21e-9 Aortic root size; CRC cis rs6712932 0.962 rs10496390 chr2:105838791 C/T cg22878388 chr2:105853796 NA -0.34 -6.54 -0.34 2.41e-10 Type 2 diabetes; CRC cis rs7615952 0.599 rs6438955 chr3:125730333 C/A cg15145296 chr3:125709740 NA -0.56 -7.12 -0.37 6.68e-12 Blood pressure (smoking interaction); CRC cis rs4654899 0.802 rs1530946 chr1:21182540 A/G cg02927042 chr1:21476669 EIF4G3 0.45 7.22 0.37 3.68e-12 Superior frontal gyrus grey matter volume; CRC cis rs7072216 0.666 rs11598689 chr10:100156027 G/T cg26618903 chr10:100175079 PYROXD2 -0.42 -6.42 -0.33 4.89e-10 Metabolite levels; CRC cis rs2050392 0.557 rs306588 chr10:30723593 G/A cg25182066 chr10:30743637 MAP3K8 -0.46 -6.09 -0.32 3.14e-9 Inflammatory bowel disease; CRC cis rs28386778 0.863 rs6504178 chr17:61812733 A/G cg22520471 chr17:61851767 DDX42;CCDC47 -0.73 -11.31 -0.53 2.88e-25 Prudent dietary pattern; CRC cis rs853679 0.517 rs3757185 chr6:28107776 T/A cg23161317 chr6:28129485 ZNF389 0.53 6.54 0.34 2.37e-10 Depression; CRC trans rs2243480 1.000 rs6970243 chr7:65388490 C/A cg10756647 chr7:56101905 PSPH 0.73 8.07 0.41 1.36e-14 Diabetic kidney disease; CRC trans rs35110281 0.622 rs9977258 chr21:44976485 G/T cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.55 9.27 0.46 2.55e-18 Mean corpuscular volume; CRC cis rs7827545 1.000 rs7827545 chr8:135566567 C/T cg13086574 chr8:135490821 ZFAT -0.35 -6.06 -0.32 3.63e-9 Hypertension (SNP x SNP interaction); CRC cis rs910187 0.641 rs6018327 chr20:45813126 C/T cg27589058 chr20:45804311 EYA2 -0.39 -7.36 -0.38 1.49e-12 Migraine; CRC cis rs7264396 0.943 rs6060448 chr20:34112192 C/G cg04508476 chr20:34239394 CPNE1;RBM12 0.43 7.23 0.37 3.5e-12 Total cholesterol levels; CRC cis rs10971721 0.822 rs41314578 chr9:33933941 T/A cg13495928 chr9:33750294 PRSS3 0.56 5.95 0.31 6.96e-9 Body mass index; CRC cis rs12711979 0.729 rs6714956 chr2:3820454 T/C cg17052675 chr2:3827356 NA -0.57 -10.77 -0.51 2.23e-23 Itch intensity from mosquito bite adjusted by bite size; CRC trans rs1493916 0.905 rs9956315 chr18:31405546 G/C cg27147174 chr7:100797783 AP1S1 -0.47 -7.91 -0.4 3.83e-14 Life satisfaction; CRC cis rs7584330 0.554 rs10208231 chr2:238433225 C/T cg14458575 chr2:238380390 NA 0.53 7.01 0.36 1.36e-11 Prostate cancer; CRC trans rs561341 1.000 rs550264 chr17:30317540 G/T cg27661571 chr11:113659931 NA -0.95 -10.99 -0.52 3.76e-24 Hip circumference adjusted for BMI; CRC cis rs34172651 0.545 rs7185291 chr16:24714679 C/T cg06028605 chr16:24865363 SLC5A11 -0.33 -6.35 -0.33 7.09e-10 Intelligence (multi-trait analysis); CRC cis rs12477438 0.520 rs6542863 chr2:99725138 C/T cg26064155 chr2:99771622 LIPT1;TSGA10 0.88 16.24 0.67 5.52e-44 Chronic sinus infection; CRC cis rs936229 0.705 rs936227 chr15:75131959 A/G cg10253484 chr15:75165896 SCAMP2 -0.37 -5.84 -0.31 1.23e-8 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); CRC cis rs853679 0.517 rs4713135 chr6:28039586 G/A cg15786705 chr6:28176104 NA 0.74 9.35 0.46 1.41e-18 Depression; CRC cis rs9303401 0.659 rs66514313 chr17:56714057 C/T cg10487724 chr17:56770010 TEX14;RAD51C 0.78 9.69 0.47 1.07e-19 Cognitive test performance; CRC cis rs4713118 0.629 rs149899 chr6:28019979 C/T cg21251018 chr6:28226885 NKAPL 0.45 6.51 0.34 2.73e-10 Parkinson's disease; CRC cis rs7192750 0.535 rs152826 chr16:72126180 A/G cg14768367 chr16:72042858 DHODH 0.85 6.44 0.33 4.18e-10 LDL cholesterol levels;Total cholesterol levels; CRC cis rs4731207 0.623 rs1600744 chr7:124585960 T/C cg23710748 chr7:124431027 NA -0.38 -6.08 -0.32 3.35e-9 Cutaneous malignant melanoma; CRC cis rs860295 0.702 rs10908479 chr1:155643403 C/T cg02153340 chr1:155202674 NA -0.53 -6.88 -0.35 3.1e-11 Body mass index; CRC cis rs1552244 0.882 rs6443279 chr3:10053599 C/A cg10729496 chr3:10149963 C3orf24 0.51 6.6 0.34 1.68e-10 Alzheimer's disease; CRC cis rs7107770 0.663 rs6590135 chr11:125073667 A/G cg27629782 chr11:125073726 PKNOX2 0.5 7.18 0.37 4.78e-12 Photic sneeze reflex; CRC cis rs4076764 0.846 rs12036398 chr1:163422204 C/T cg24596788 chr1:163392923 NA 0.55 8.63 0.43 2.71e-16 Motion sickness; CRC cis rs4731207 0.671 rs6466949 chr7:124444900 T/C cg23710748 chr7:124431027 NA 0.37 5.96 0.31 6.53e-9 Cutaneous malignant melanoma; CRC cis rs3820068 0.532 rs1547034 chr1:15919049 T/A cg24675056 chr1:15929824 NA 0.46 6.32 0.33 8.53e-10 Systolic blood pressure; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg25937884 chr5:180674133 NA 0.4 5.98 0.31 5.96e-9 Response to antipsychotic treatment; CRC trans rs1455244 0.700 rs7229302 chr18:11508904 G/T cg01481784 chr1:161369725 NA 0.4 6.17 0.32 2e-9 Schizophrenia; CRC cis rs10229583 0.527 rs6943385 chr7:127308428 C/G cg01233922 chr7:127693937 SND1 0.45 6.72 0.35 7.86e-11 Type 2 diabetes; CRC trans rs9858542 0.953 rs1801143 chr3:49570200 C/T cg21582582 chr3:182698605 DCUN1D1 -0.54 -6.8 -0.35 4.85e-11 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs10504229 0.645 rs6995814 chr8:58114159 C/T cg22535103 chr8:58192502 C8orf71 -0.69 -9.23 -0.45 3.37e-18 Developmental language disorder (linguistic errors); CRC cis rs2739330 0.760 rs1002286 chr22:24257337 A/G cg04234412 chr22:24373322 LOC391322 0.79 13.98 0.61 3.42e-35 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs765787 0.530 rs4775831 chr15:45534722 A/C cg24006582 chr15:45444508 DUOX1 -0.57 -8.79 -0.44 8.5e-17 Uric acid levels; CRC cis rs28386778 0.897 rs1062790 chr17:61896455 A/G cg22520471 chr17:61851767 DDX42;CCDC47 0.75 11.75 0.54 7.35e-27 Prudent dietary pattern; CRC cis rs3857536 0.741 rs9363556 chr6:66934399 T/C cg07460842 chr6:66804631 NA -0.42 -5.71 -0.3 2.5e-8 Blood trace element (Cu levels); CRC cis rs2228479 0.850 rs11646766 chr16:89838578 A/T cg06656553 chr16:89960601 TCF25 -0.69 -5.74 -0.3 2.17e-8 Skin colour saturation; CRC cis rs3751196 0.711 rs78345851 chr12:104226206 C/T cg02344784 chr12:104178138 NT5DC3 0.7 7.16 0.37 5.32e-12 Sense of smell; CRC cis rs9868809 0.505 rs35064573 chr3:48740280 C/A cg07636037 chr3:49044803 WDR6 -0.68 -6.53 -0.34 2.57e-10 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; CRC cis rs2019137 0.560 rs10206269 chr2:113990393 C/A cg12889195 chr2:113992843 PAX8;LOC440839;LOC654433 0.63 9.51 0.46 4.05e-19 Lymphocyte counts; CRC cis rs1799949 1.000 rs4793231 chr17:41427469 A/G cg01879757 chr17:41196368 BRCA1 -0.41 -6.06 -0.32 3.67e-9 Menopause (age at onset); CRC cis rs4588572 0.606 rs6859161 chr5:77742776 A/G cg11547950 chr5:77652471 NA -0.48 -7.03 -0.36 1.19e-11 Triglycerides; CRC trans rs7179994 0.579 rs111884664 chr15:28300834 C/A cg05237436 chr5:138533428 SIL1 0.71 6.29 0.33 1.03e-9 Shingles; CRC cis rs1355223 0.583 rs2941060 chr11:34879154 G/A cg11058730 chr11:34937778 PDHX;APIP 0.72 11.63 0.54 2.02e-26 Systemic lupus erythematosus and Systemic sclerosis; CRC cis rs8017423 0.647 rs12589952 chr14:90821364 T/C cg14092571 chr14:90743983 NA 0.38 5.89 0.31 9.61e-9 Mortality in heart failure; CRC cis rs6938 0.575 rs12909335 chr15:75214789 T/G cg17294928 chr15:75287854 SCAMP5 0.56 8.6 0.43 3.21e-16 Breast cancer; CRC cis rs13108904 0.967 rs11730939 chr4:1285560 G/A cg00684032 chr4:1343700 KIAA1530 0.47 6.82 0.35 4.46e-11 Obesity-related traits; CRC cis rs6840360 0.571 rs7664663 chr4:152508014 G/C cg09659197 chr4:152720779 NA 0.32 5.75 0.3 2.09e-8 Intelligence (multi-trait analysis); CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg14264380 chr17:79651103 ARL16;HGS 0.44 6.31 0.33 8.93e-10 Anxiety disorder; CRC cis rs17253792 0.822 rs10483645 chr14:56103766 G/T cg24579896 chr14:56047964 C14orf33;KTN1 0.71 5.67 0.3 3.16e-8 Putamen volume; CRC cis rs9308731 0.688 rs4302219 chr2:111880284 G/T cg18646521 chr2:111875858 NA 0.39 6.2 0.32 1.64e-9 Chronic lymphocytic leukemia; CRC cis rs12893668 0.572 rs2273175 chr14:104160141 T/C cg01849466 chr14:104193079 ZFYVE21 -0.41 -6.19 -0.32 1.74e-9 Reticulocyte count; CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg22478328 chr22:32340140 C22orf24;YWHAH -0.53 -6.43 -0.33 4.39e-10 Diisocyanate-induced asthma; CRC cis rs8180040 0.966 rs4858868 chr3:47455086 G/A cg02527881 chr3:46936655 PTH1R -0.39 -7.47 -0.38 7.17e-13 Colorectal cancer; CRC cis rs1005277 0.579 rs1780137 chr10:38501475 C/G cg25427524 chr10:38739819 LOC399744 -0.76 -13.29 -0.59 1.49e-32 Extrinsic epigenetic age acceleration; CRC trans rs8002861 0.658 rs9533635 chr13:44397921 C/A cg12856521 chr11:46389249 DGKZ -0.5 -8.27 -0.41 3.26e-15 Leprosy; CRC trans rs587242 1.000 rs12758621 chr1:96898421 C/T cg10631902 chr5:14652156 NA 0.44 6.83 0.35 4.06e-11 Body mass index (joint analysis main effects and physical activity interaction);Body mass index in physically inactive individuals;Body mass index; CRC cis rs4727027 0.933 rs7788925 chr7:148831621 A/G cg23583168 chr7:148888333 NA -0.88 -14.83 -0.63 1.87e-38 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC cis rs9463078 0.547 rs4449629 chr6:44717808 T/C cg25276700 chr6:44698697 NA 0.32 8.07 0.41 1.31e-14 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; CRC cis rs3858145 0.588 rs61854831 chr10:70035837 C/T cg06988349 chr10:69991859 ATOH7 0.36 5.71 0.3 2.59e-8 Optic nerve measurement (disc area);Optic cup area;Optic nerve measurement (cup area); CRC cis rs67311347 0.956 rs4974029 chr3:40521318 C/G cg24209194 chr3:40518798 ZNF619 0.42 6.18 0.32 1.85e-9 Renal cell carcinoma; CRC trans rs3743266 0.613 rs2414669 chr15:60708824 A/G cg19296258 chr17:78878799 RPTOR 0.4 6.05 0.32 3.87e-9 Menarche (age at onset); CRC cis rs7512552 0.966 rs1122967 chr1:150258838 C/G cg15654264 chr1:150340011 RPRD2 -0.55 -8.12 -0.41 9.58e-15 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); CRC trans rs8141529 0.507 rs5762936 chr22:29381377 A/G cg25408707 chr6:160393049 IGF2R -0.55 -6.1 -0.32 2.94e-9 Lymphocyte counts; CRC trans rs2243480 1.000 rs313807 chr7:65499481 C/T cg10756647 chr7:56101905 PSPH 0.78 8.32 0.42 2.42e-15 Diabetic kidney disease; CRC cis rs7264396 0.513 rs3787169 chr20:34419884 G/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.47 -6.75 -0.35 6.82e-11 Total cholesterol levels; CRC cis rs7589728 1.000 rs7589728 chr2:88518440 G/A cg04511125 chr2:88470314 THNSL2 0.68 6.91 0.36 2.53e-11 Plasma clusterin levels; CRC cis rs10504229 0.683 rs113492050 chr8:58130046 A/G cg24829409 chr8:58192753 C8orf71 -0.55 -8.03 -0.4 1.71e-14 Developmental language disorder (linguistic errors); CRC cis rs4972806 0.776 rs2072589 chr2:177042871 C/T cg13092806 chr2:177043255 NA 0.77 12.53 0.57 1.03e-29 IgG glycosylation; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg00408597 chr11:9685941 SWAP70 0.39 5.98 0.31 5.69e-9 Liver disease severity in Alagille syndrome; CRC cis rs6951245 0.935 rs118132455 chr7:1068232 C/A cg03188948 chr7:1209495 NA 0.63 6.52 0.34 2.64e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg01334186 chr1:151372572 PSMB4 -0.5 -6.18 -0.32 1.88e-9 Diisocyanate-induced asthma; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg22522509 chr21:16436121 NRIP1 0.39 6.32 0.33 8.66e-10 Liver disease severity in Alagille syndrome; CRC cis rs2295359 1.000 rs10889664 chr1:67635475 C/T cg03340356 chr1:67600835 NA 0.26 5.87 0.31 1.09e-8 Psoriasis; CRC cis rs8105895 0.935 rs9653142 chr19:22249596 A/G cg02657401 chr19:22469223 NA -0.34 -5.65 -0.3 3.56e-8 Body mass index (change over time); CRC cis rs67311347 0.955 rs4973999 chr3:40460383 G/A cg09455208 chr3:40491958 NA 0.46 9.49 0.46 4.98e-19 Renal cell carcinoma; CRC cis rs2032447 0.507 rs199748 chr6:25909045 C/G cg03517284 chr6:25882590 NA -0.79 -11.34 -0.53 2.19e-25 Intelligence (multi-trait analysis); CRC cis rs7618915 0.547 rs13085895 chr3:52678270 G/C cg08222913 chr3:52553049 STAB1 -0.34 -6.14 -0.32 2.4e-9 Bipolar disorder; CRC cis rs2204008 0.715 rs3899385 chr12:38169880 C/G cg26384229 chr12:38710491 ALG10B 0.67 8.93 0.44 3.04e-17 Bladder cancer; CRC cis rs4664308 0.806 rs4665162 chr2:161060184 A/G cg03641300 chr2:160917029 PLA2R1 -0.72 -11.84 -0.55 3.54e-27 Idiopathic membranous nephropathy; CRC trans rs3749237 1.000 rs11710675 chr3:49751900 C/A cg21665057 chr3:196295764 WDR53;FBXO45 0.57 8.19 0.41 5.91e-15 Resting heart rate; CRC cis rs754466 0.580 rs2289308 chr10:79579251 G/A cg26805224 chr10:79626177 DLG5 -0.5 -7.34 -0.38 1.68e-12 Liver enzyme levels (gamma-glutamyl transferase); CRC trans rs875971 0.660 rs2191268 chr7:66110224 C/T cg04483163 chr1:147806437 NA -0.41 -6.59 -0.34 1.75e-10 Aortic root size; CRC cis rs11098499 0.754 rs12506610 chr4:120241659 T/C cg09307838 chr4:120376055 NA 0.62 9.71 0.47 9.4e-20 Corneal astigmatism; CRC cis rs2797160 0.935 rs926855 chr6:126021782 A/G cg05901451 chr6:126070800 HEY2 0.4 6.12 0.32 2.62e-9 Endometrial cancer; CRC cis rs798554 0.686 rs2644298 chr7:2858448 G/C cg17321639 chr7:2759063 NA -0.4 -6.07 -0.32 3.5e-9 Height; CRC cis rs11971779 0.680 rs6467848 chr7:139080205 T/A cg07862535 chr7:139043722 LUC7L2 0.58 7.38 0.38 1.3e-12 Diisocyanate-induced asthma; CRC cis rs3768617 0.510 rs7414273 chr1:183075017 T/C ch.1.3577855R chr1:183094577 LAMC1 0.87 15.46 0.65 6.33e-41 Fuchs's corneal dystrophy; CRC cis rs8072100 0.967 rs4794001 chr17:45720849 T/C cg25173405 chr17:45401733 C17orf57 -0.44 -6.82 -0.35 4.28e-11 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs10170846 0.861 rs12694582 chr2:223521955 G/C cg25565276 chr2:223520875 FARSB 0.46 6.17 0.32 1.96e-9 Schizophrenia (inflammation and infection response interaction); CRC cis rs727479 0.543 rs8023263 chr15:51517597 G/T cg19946085 chr15:51559439 CYP19A1 -0.3 -6.06 -0.32 3.76e-9 Estradiol levels; CRC cis rs941408 0.515 rs4624312 chr19:2774460 T/C cg17333051 chr19:2783644 SGTA 0.47 6.9 0.36 2.69e-11 Total cholesterol levels; CRC cis rs10791323 0.569 rs2282602 chr11:133714522 G/A cg15485101 chr11:133734466 NA 0.44 7.52 0.38 5.43e-13 Childhood ear infection; CRC cis rs9463078 0.803 rs2396380 chr6:45043557 T/A cg25276700 chr6:44698697 NA -0.28 -6.71 -0.35 8.49e-11 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; CRC cis rs9322193 0.962 rs3805753 chr6:150116798 C/T cg00933542 chr6:150070202 PCMT1 0.28 5.63 0.3 3.86e-8 Lung cancer; CRC cis rs3741151 0.686 rs7114009 chr11:73115314 C/T cg17517138 chr11:73019481 ARHGEF17 -0.5 -5.61 -0.3 4.27e-8 GIP levels in response to oral glucose tolerance test (120 minutes); CRC cis rs9300255 0.664 rs7306755 chr12:123767929 G/A cg00376283 chr12:123451042 ABCB9 -0.54 -6.14 -0.32 2.42e-9 Neutrophil percentage of white cells; CRC cis rs992157 0.798 rs7587220 chr2:219160864 C/A cg04731861 chr2:219085781 ARPC2 0.31 6.36 0.33 6.89e-10 Colorectal cancer; CRC cis rs2180341 0.960 rs7753913 chr6:127671296 A/G cg24812749 chr6:127587940 RNF146 0.95 13.32 0.59 1.16e-32 Breast cancer; CRC cis rs2836974 0.583 rs9636957 chr21:40705847 G/A cg17971929 chr21:40555470 PSMG1 -0.65 -9.59 -0.47 2.22e-19 Cognitive function; CRC cis rs7618915 0.501 rs1468638 chr3:52748058 T/C cg18404041 chr3:52824283 ITIH1 -0.4 -8.28 -0.42 3.21e-15 Bipolar disorder; CRC trans rs12663356 0.528 rs9350359 chr6:21462624 C/T cg09844983 chr1:28240714 RPA2 0.4 6.02 0.31 4.62e-9 Crohn's disease; CRC cis rs7917772 0.560 rs4919664 chr10:104363408 A/C cg11453585 chr10:104263688 ACTR1A;SUFU 0.82 15.29 0.64 3.08e-40 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC trans rs853679 0.769 rs17720293 chr6:28214698 C/T cg01620082 chr3:125678407 NA -0.74 -6.23 -0.32 1.47e-9 Depression; CRC cis rs704795 0.836 rs1083865 chr2:27620827 A/G cg12648201 chr2:27665141 KRTCAP3 -0.3 -5.94 -0.31 7.33e-9 Menopause (age at onset); CRC cis rs727505 0.909 rs1031958 chr7:124627309 C/T cg23710748 chr7:124431027 NA -0.81 -14.15 -0.62 7.86e-36 Lewy body disease; CRC cis rs10883723 0.810 rs7917525 chr10:104246755 C/G cg11453585 chr10:104263688 ACTR1A;SUFU 0.91 17.37 0.69 2.02e-48 Allergic disease (asthma, hay fever or eczema); CRC cis rs10504229 0.554 rs17802082 chr8:58095867 C/T cg21724239 chr8:58056113 NA 0.62 8.41 0.42 1.3e-15 Developmental language disorder (linguistic errors); CRC cis rs12142240 0.667 rs45524035 chr1:46862780 C/T cg14993813 chr1:46806288 NSUN4 -0.48 -6.08 -0.32 3.39e-9 Menopause (age at onset); CRC cis rs965469 0.947 rs6037578 chr20:3345911 T/C cg25506879 chr20:3388711 C20orf194 -0.4 -5.77 -0.3 1.81e-8 IFN-related cytopenia; CRC cis rs6988985 0.765 rs4736317 chr8:143982753 A/G cg10324643 chr8:143916377 GML 0.38 6.17 0.32 2.01e-9 Plasma androstenedione levels in resected early stage-receptor positive breast cancer; CRC cis rs10924970 0.649 rs1933247 chr1:235432767 A/G cg09010748 chr1:235293032 TOMM20 -0.42 -5.77 -0.3 1.8e-8 Asthma; CRC cis rs2425143 0.730 rs6060624 chr20:34413663 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.5 -6.18 -0.32 1.93e-9 Blood protein levels; CRC cis rs10504229 0.683 rs61201557 chr8:58138370 T/C cg05313129 chr8:58192883 C8orf71 -0.43 -6.11 -0.32 2.74e-9 Developmental language disorder (linguistic errors); CRC cis rs8060686 0.858 rs1109166 chr16:67977382 T/C cg26727032 chr16:67993705 SLC12A4 -0.69 -10.53 -0.5 1.57e-22 HDL cholesterol;Metabolic syndrome; CRC cis rs6762 0.748 rs5030780 chr11:838110 C/T cg11173246 chr11:841376 TSPAN4;POLR2L -0.35 -5.88 -0.31 9.96e-9 Mean platelet volume; CRC cis rs17666538 0.585 rs1669733 chr8:606696 C/T cg27048067 chr8:674560 ERICH1 -0.53 -5.84 -0.31 1.26e-8 IgG glycosylation; CRC cis rs10540 1.000 rs35996687 chr11:458595 G/A cg08200582 chr11:442649 ANO9 -0.66 -6.33 -0.33 7.93e-10 Body mass index; CRC cis rs1355223 1.000 rs1355221 chr11:34758609 G/A cg11058730 chr11:34937778 PDHX;APIP -0.41 -5.67 -0.3 3.17e-8 Systemic lupus erythematosus and Systemic sclerosis; CRC cis rs6547741 0.844 rs9678851 chr2:27887034 C/A cg22903471 chr2:27725779 GCKR -0.34 -5.63 -0.3 3.91e-8 Oral cavity cancer; CRC cis rs1448094 0.512 rs60986162 chr12:86247054 T/G cg25456477 chr12:86230367 RASSF9 0.34 5.99 0.31 5.54e-9 Major depressive disorder; CRC cis rs4478858 0.684 rs12403136 chr1:31728920 A/G cg00250761 chr1:31883323 NA -0.41 -7.84 -0.4 6.13e-14 Alcohol dependence; CRC trans rs7267979 0.780 rs2500413 chr20:25241155 T/C cg17903999 chr18:56338584 MALT1 -0.42 -6.59 -0.34 1.73e-10 Liver enzyme levels (alkaline phosphatase); CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg06866400 chr6:143771904 ADAT2;PEX3 0.38 6.0 0.31 5.23e-9 Obesity-related traits; CRC trans rs11227306 0.934 rs7102454 chr11:65594820 C/T cg17712092 chr4:129076599 LARP1B -0.52 -7.11 -0.36 7.28e-12 DNA methylation (variation); CRC cis rs1552244 1.000 rs113771705 chr3:10075983 T/C cg16606324 chr3:10149918 C3orf24 0.73 9.77 0.47 5.73e-20 Alzheimer's disease; CRC trans rs7395662 0.571 rs10838947 chr11:48568693 G/T cg21153622 chr11:89784906 NA -0.51 -8.48 -0.42 7.88e-16 HDL cholesterol; CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg05360402 chr5:110848191 STARD4 -0.52 -6.33 -0.33 7.9e-10 Diisocyanate-induced asthma; CRC trans rs10983614 1.000 rs7867776 chr9:120072627 A/G cg14331148 chr19:47551893 TMEM160 0.44 6.27 0.33 1.12e-9 Survival in pancreatic cancer; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg13237843 chr11:6640720 TPP1 0.47 6.7 0.35 8.85e-11 Response to antipsychotic treatment; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg21889078 chr8:56675203 TMEM68 -0.39 -6.56 -0.34 2.1e-10 Liver disease severity in Alagille syndrome; CRC cis rs6445525 0.935 rs6806075 chr3:66000650 G/T cg06109867 chr3:66002991 MAGI1 -0.4 -6.55 -0.34 2.21e-10 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg26618056 chr16:25043323 NA 0.4 6.64 0.34 1.28e-10 Liver disease severity in Alagille syndrome; CRC cis rs7666738 0.830 rs1813251 chr4:98921170 A/G cg17366294 chr4:99064904 C4orf37 0.43 7.25 0.37 2.97e-12 Colonoscopy-negative controls vs population controls; CRC cis rs4919694 0.572 rs12255989 chr10:104867206 C/T cg04362960 chr10:104952993 NT5C2 0.9 9.49 0.46 4.71e-19 Arsenic metabolism; CRC cis rs6076065 0.723 rs1419009 chr20:23365094 G/A cg11657817 chr20:23433608 CST11 0.47 6.9 0.36 2.64e-11 Facial morphology (factor 15, philtrum width); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg18141918 chr10:89622539 PTEN;KILLIN 0.38 6.07 0.32 3.5e-9 Liver disease severity in Alagille syndrome; CRC cis rs548181 0.611 rs1293672 chr11:125461034 A/G cg03464685 chr11:125439445 EI24 1.28 13.03 0.58 1.36e-31 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg18462168 chr15:22892545 CYFIP1 0.45 6.34 0.33 7.52e-10 Response to antipsychotic treatment; CRC cis rs9549367 0.756 rs9603814 chr13:113900782 C/T cg24300038 chr13:113819356 PROZ 0.42 5.73 0.3 2.28e-8 Platelet distribution width; CRC cis rs10504229 1.000 rs58947041 chr8:58188934 G/A cg22535103 chr8:58192502 C8orf71 -0.81 -12.25 -0.56 1.07e-28 Developmental language disorder (linguistic errors); CRC cis rs57590327 0.508 rs9820349 chr3:81958587 A/G cg07356753 chr3:81810745 GBE1 -0.59 -7.95 -0.4 3.06e-14 Extraversion; CRC cis rs4665809 0.887 rs4665814 chr2:26273687 G/T cg04944784 chr2:26401820 FAM59B -0.57 -7.52 -0.38 5.3e-13 Gut microbiome composition (summer); CRC cis rs10504229 0.683 rs17194487 chr8:58104912 C/T cg22535103 chr8:58192502 C8orf71 -0.77 -8.61 -0.43 3.04e-16 Developmental language disorder (linguistic errors); CRC cis rs9549260 0.564 rs12184871 chr13:41291928 C/A cg21288729 chr13:41239152 FOXO1 0.43 6.73 0.35 7.66e-11 Red blood cell count; CRC cis rs9457247 0.765 rs12212247 chr6:167413539 T/C cg07741184 chr6:167504864 NA 0.39 6.66 0.34 1.17e-10 Crohn's disease; CRC cis rs4716602 0.633 rs10249382 chr7:156159349 G/T cg16983916 chr7:156159713 NA -0.41 -7.2 -0.37 4.03e-12 Anti-saccade response; CRC cis rs6860806 0.507 rs272891 chr5:131664394 G/T cg09877947 chr5:131593287 PDLIM4 0.44 7.14 0.37 5.89e-12 Breast cancer; CRC cis rs1401999 1.000 rs869417 chr3:183689138 T/C cg20387954 chr3:183756860 HTR3D 0.44 7.55 0.38 4.43e-13 Anterior chamber depth; CRC cis rs3823572 0.542 rs2971974 chr7:133644598 C/T cg03336402 chr7:133662267 EXOC4 0.68 10.57 0.5 1.1e-22 Intelligence (multi-trait analysis); CRC cis rs1448094 0.511 rs10863080 chr12:86153149 C/T cg06740227 chr12:86229804 RASSF9 -0.38 -5.78 -0.3 1.74e-8 Major depressive disorder; CRC cis rs11148252 0.508 rs1886542 chr13:52706281 A/C cg00495681 chr13:53174319 NA 0.62 9.28 0.46 2.27e-18 Lewy body disease; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg00660251 chr1:89991016 LRRC8B 0.4 6.28 0.33 1.05e-9 Liver disease severity in Alagille syndrome; CRC cis rs9649213 0.593 rs7458551 chr7:97952167 G/C cg00277769 chr7:97922759 BAIAP2L1 -0.61 -10.65 -0.51 5.96e-23 Prostate cancer (SNP x SNP interaction); CRC cis rs9910055 0.529 rs368328 chr17:42170289 G/A cg10896456 chr17:42255109 ASB16;C17orf65 -0.38 -5.92 -0.31 7.92e-9 Total body bone mineral density; CRC cis rs7209700 0.889 rs16941801 chr17:45354543 G/C cg17185639 chr17:45330862 ITGB3 0.35 5.84 0.31 1.27e-8 IgG glycosylation; CRC cis rs11155671 0.530 rs2342769 chr6:150216507 T/C cg13206674 chr6:150067644 NUP43 0.52 7.22 0.37 3.67e-12 Testicular germ cell tumor; CRC cis rs3741151 0.764 rs79892955 chr11:73096280 G/T cg17517138 chr11:73019481 ARHGEF17 0.88 7.43 0.38 9.29e-13 GIP levels in response to oral glucose tolerance test (120 minutes); CRC cis rs775227 0.574 rs13067967 chr3:113265215 C/G cg10517650 chr3:113235015 CCDC52 -0.39 -5.63 -0.3 3.88e-8 Dental caries; CRC cis rs2976388 0.556 rs4736300 chr8:143829269 C/T cg10596483 chr8:143751796 JRK -0.49 -6.84 -0.35 3.88e-11 Urinary tract infection frequency; CRC cis rs2070488 0.965 rs3749386 chr3:38496065 C/T cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.92 17.41 0.69 1.38e-48 Electrocardiographic conduction measures; CRC cis rs73200209 0.912 rs2288134 chr12:116441395 G/T cg01776926 chr12:116560359 MED13L -0.53 -6.47 -0.34 3.58e-10 Total body bone mineral density; CRC cis rs6582630 0.560 rs4882325 chr12:38510037 C/T cg26384229 chr12:38710491 ALG10B -0.54 -7.79 -0.39 8.63e-14 Drug-induced liver injury (flucloxacillin); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg04720665 chr1:245028075 HNRNPU 0.48 6.86 0.35 3.33e-11 Response to antipsychotic treatment; CRC trans rs728616 0.681 rs34816332 chr10:81907967 G/A cg18543242 chr14:23290393 SLC7A7 0.48 6.47 0.34 3.58e-10 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs1572438 0.896 rs9405366 chr6:858296 A/C cg13447295 chr6:887704 NA -0.55 -7.39 -0.38 1.22e-12 Aging; CRC cis rs853679 0.760 rs967005 chr6:28210688 C/T cg02683197 chr6:28174875 NA 0.64 6.54 0.34 2.37e-10 Depression; CRC cis rs968567 0.906 rs61897793 chr11:61599347 G/A cg00614641 chr11:61596405 FADS2 -0.57 -6.6 -0.34 1.63e-10 Blood metabolite levels;Rheumatoid arthritis;Vitiligo;Glycerophospholipid levels; CRC cis rs853679 0.550 rs1150689 chr6:28165099 T/C cg21251018 chr6:28226885 NKAPL 0.46 6.57 0.34 1.97e-10 Depression; CRC trans rs7594321 0.931 rs4973193 chr2:230230104 A/G ch.3.5198520F chr3:5223520 NA 0.41 5.96 0.31 6.54e-9 Pulmonary function (smoking interaction); CRC cis rs6502050 0.835 rs4789677 chr17:80119842 A/G cg25804541 chr17:80189381 SLC16A3 -0.31 -5.95 -0.31 6.84e-9 Life satisfaction; CRC cis rs317689 0.513 rs317659 chr12:69686132 T/A cg14784868 chr12:69753453 YEATS4 0.63 9.74 0.47 7.22e-20 Response to diuretic therapy; CRC cis rs6426558 0.537 rs4500279 chr1:227484482 G/A cg10327440 chr1:227177885 CDC42BPA 0.42 6.35 0.33 7.28e-10 Neutrophil percentage of white cells; CRC cis rs7523050 0.558 rs35926243 chr1:109407712 T/A cg08274380 chr1:109419600 GPSM2 0.9 6.76 0.35 6.12e-11 Fat distribution (HIV); CRC cis rs9322193 0.923 rs12175504 chr6:149985215 T/G cg05861140 chr6:150128134 PCMT1 -0.43 -6.93 -0.36 2.17e-11 Lung cancer; CRC cis rs3820068 0.581 rs72645888 chr1:15929922 C/A cg27534772 chr1:16042836 PLEKHM2 0.54 10.46 0.5 2.7e-22 Systolic blood pressure; CRC cis rs172166 0.611 rs203883 chr6:28078356 A/G cg15786705 chr6:28176104 NA 0.62 8.75 0.43 1.12e-16 Cardiac Troponin-T levels; CRC cis rs7020830 0.898 rs308523 chr9:37338785 C/T cg14294708 chr9:37120828 ZCCHC7 0.99 18.28 0.71 5.27e-52 Schizophrenia; CRC cis rs4665809 1.000 rs1550382 chr2:26266877 T/G cg27170947 chr2:26402098 FAM59B -0.44 -5.81 -0.3 1.51e-8 Gut microbiome composition (summer); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg15045943 chr5:171614719 STK10 0.47 6.69 0.35 9.9e-11 Response to antipsychotic treatment; CRC cis rs1005277 0.522 rs9417256 chr10:37976990 A/G cg25427524 chr10:38739819 LOC399744 -0.74 -12.96 -0.58 2.57e-31 Extrinsic epigenetic age acceleration; CRC cis rs4665809 1.000 rs11678157 chr2:26321526 T/C cg25036284 chr2:26402008 FAM59B -0.44 -5.9 -0.31 8.98e-9 Gut microbiome composition (summer); CRC cis rs10504229 0.815 rs72650877 chr8:58164510 T/C cg02290350 chr8:58132656 NA -0.5 -6.19 -0.32 1.75e-9 Developmental language disorder (linguistic errors); CRC cis rs1552244 1.000 rs9849434 chr3:10133710 A/G cg18598329 chr3:10140678 FANCD2;C3orf24 0.92 13.49 0.6 2.49e-33 Alzheimer's disease; CRC cis rs10876993 0.890 rs774888 chr12:58036506 A/G cg18357645 chr12:58087776 OS9 0.53 7.19 0.37 4.35e-12 Celiac disease or Rheumatoid arthritis; CRC cis rs13256369 1.000 rs9329166 chr8:8576655 C/T cg18904891 chr8:8559673 CLDN23 0.54 6.9 0.36 2.74e-11 Obesity-related traits; CRC trans rs1916521 0.519 rs7914545 chr10:57420576 C/A cg16731318 chr1:94313343 NA -0.43 -6.01 -0.31 4.85e-9 Cardiac hypertrophy; CRC cis rs10504229 0.683 rs16921808 chr8:58106049 C/T cg24829409 chr8:58192753 C8orf71 -0.58 -7.94 -0.4 3.24e-14 Developmental language disorder (linguistic errors); CRC cis rs2032447 0.714 rs175319 chr6:25956172 A/G cg03517284 chr6:25882590 NA -0.61 -8.53 -0.43 5.28e-16 Intelligence (multi-trait analysis); CRC cis rs6460942 0.915 rs62448620 chr7:12458170 C/T cg06484146 chr7:12443880 VWDE -0.78 -8.1 -0.41 1.11e-14 Coronary artery disease; CRC trans rs4843747 0.671 rs28679286 chr16:88106307 C/T cg26811252 chr16:29126840 RRN3P2 0.61 8.31 0.42 2.62e-15 Menopause (age at onset); CRC cis rs35146811 0.735 rs1727139 chr7:99815367 C/T cg13334819 chr7:99746414 C7orf59 0.52 6.74 0.35 7.02e-11 Coronary artery disease; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg04139300 chr20:40247070 CHD6 0.5 6.68 0.35 1.01e-10 Thyroid stimulating hormone; CRC cis rs7666738 0.830 rs1967979 chr4:98966201 G/T cg05340658 chr4:99064831 C4orf37 0.61 9.45 0.46 6.55e-19 Colonoscopy-negative controls vs population controls; CRC cis rs2404602 0.684 rs4886816 chr15:76874707 A/C cg03037974 chr15:76606532 NA -0.5 -7.46 -0.38 7.86e-13 Blood metabolite levels; CRC cis rs6540559 0.673 rs6540560 chr1:209982073 A/G cg22029157 chr1:209979665 IRF6 -0.68 -9.22 -0.45 3.53e-18 Cleft lip with or without cleft palate; CRC cis rs11792861 0.962 rs72607161 chr9:111792640 T/C cg05043794 chr9:111880884 C9orf5 -0.35 -6.34 -0.33 7.45e-10 Menarche (age at onset); CRC cis rs2976388 0.506 rs2572902 chr8:143791387 A/G cg24046110 chr8:143859143 LYNX1 0.49 8.61 0.43 3.15e-16 Urinary tract infection frequency; CRC cis rs9311474 0.967 rs11717383 chr3:52287468 G/T cg15147215 chr3:52552868 STAB1 -0.65 -11.31 -0.53 2.8e-25 Electroencephalogram traits; CRC cis rs7178572 1.000 rs34591043 chr15:77713586 A/G cg22256960 chr15:77711686 NA -0.69 -10.65 -0.51 5.92e-23 Type 2 diabetes; CRC cis rs9611565 0.918 rs9611562 chr22:41760172 T/G cg06634786 chr22:41940651 POLR3H -0.65 -7.54 -0.38 4.59e-13 Vitiligo; CRC trans rs57590327 0.503 rs1461611 chr3:81512061 C/A cg23387109 chr10:94051229 MARCH5;CPEB3 -0.44 -6.0 -0.31 5.25e-9 Extraversion; CRC cis rs10540 1.000 rs61876340 chr11:495699 A/C cg19913688 chr11:428466 ANO9 -0.7 -7.21 -0.37 3.76e-12 Body mass index; CRC cis rs3857067 0.806 rs7676797 chr4:95099194 G/A cg11021082 chr4:95130006 SMARCAD1 -0.41 -6.18 -0.32 1.89e-9 QT interval; CRC cis rs728616 0.867 rs28365998 chr10:81965436 C/A cg11900509 chr10:81946545 ANXA11 -0.77 -7.17 -0.37 5.08e-12 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs2304069 0.545 rs7728248 chr5:149394965 A/G cg12661370 chr5:149340060 SLC26A2 0.43 6.21 0.32 1.62e-9 HIV-1 control; CRC cis rs11608355 0.521 rs7976839 chr12:109830534 C/A cg19025524 chr12:109796872 NA -0.56 -9.01 -0.44 1.74e-17 Neuroticism; CRC cis rs9309413 0.679 rs6717329 chr2:68555700 C/T cg21581504 chr2:68545960 CNRIP1 -0.33 -6.09 -0.32 3.13e-9 Metabolite levels; CRC cis rs11191419 1 rs11191419 chr10:104612335 T/A cg08772003 chr10:104629869 AS3MT -0.4 -6.7 -0.35 9.14e-11 Autism spectrum disorder or schizophrenia;Schizophrenia; CRC cis rs7927771 1.000 rs12361031 chr11:47783076 G/A cg05585544 chr11:47624801 NA -0.62 -10.82 -0.51 1.47e-23 Subjective well-being; CRC cis rs10751667 0.577 rs7946461 chr11:974035 A/G cg01483505 chr11:975446 AP2A2 0.46 7.59 0.39 3.23e-13 Alzheimer's disease (late onset); CRC cis rs9902453 0.542 rs3809789 chr17:27955761 A/G cg26525008 chr17:28256777 EFCAB5;SSH2 0.53 8.01 0.4 2.01e-14 Coffee consumption (cups per day); CRC cis rs709400 1.000 rs55885592 chr14:104126024 C/T cg12935359 chr14:103987150 CKB -0.37 -6.19 -0.32 1.83e-9 Body mass index; CRC cis rs25422 0.878 rs55894300 chr6:118982076 T/A cg07617317 chr6:118971624 C6orf204 0.51 5.88 0.31 1.02e-8 Renal cell carcinoma; CRC trans rs6546324 0.625 rs2861695 chr2:67846727 A/G cg00907274 chr3:27498161 SLC4A7 -0.49 -6.14 -0.32 2.38e-9 Endometriosis; CRC cis rs2573652 0.722 rs12914180 chr15:100544416 T/C cg00587665 chr15:100533223 ADAMTS17 -0.34 -5.88 -0.31 9.84e-9 Height; CRC cis rs13082711 0.911 rs11719386 chr3:27505636 G/C cg02860705 chr3:27208620 NA 0.62 8.6 0.43 3.36e-16 Systolic blood pressure;Diastolic blood pressure;Blood pressure; CRC cis rs8072100 0.640 rs3851808 chr17:45425144 C/T cg08085267 chr17:45401833 C17orf57 -0.6 -9.44 -0.46 7.22e-19 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs950776 0.518 rs12910978 chr15:78810017 A/G cg06917634 chr15:78832804 PSMA4 0.67 10.62 0.51 7.51e-23 Sudden cardiac arrest; CRC cis rs10504229 0.639 rs56066782 chr8:58105857 A/G cg05313129 chr8:58192883 C8orf71 -0.43 -5.87 -0.31 1.09e-8 Developmental language disorder (linguistic errors); CRC cis rs449789 0.857 rs687314 chr6:159716262 G/C cg14500486 chr6:159655392 FNDC1 -0.48 -7.29 -0.37 2.38e-12 Pulse pressure; CRC cis rs12701220 0.847 rs10272002 chr7:1047615 A/G cg26769984 chr7:1090371 C7orf50 0.68 9.02 0.45 1.57e-17 Bronchopulmonary dysplasia; CRC cis rs4332037 0.522 rs4721098 chr7:1881527 G/C cg21155852 chr7:2048760 MAD1L1 0.42 6.1 0.32 3.02e-9 Bipolar disorder; CRC cis rs4466137 0.953 rs1420654 chr5:82975793 G/A cg16102102 chr5:83017553 HAPLN1 -0.54 -7.63 -0.39 2.52e-13 Prostate cancer; CRC cis rs4665809 0.590 rs6749046 chr2:26429451 C/G cg25036284 chr2:26402008 FAM59B 0.62 7.95 0.4 2.92e-14 Gut microbiome composition (summer); CRC cis rs10256972 0.681 rs6979076 chr7:1116247 C/T cg23708337 chr7:1209742 NA -0.42 -6.33 -0.33 7.88e-10 Longevity;Endometriosis; CRC cis rs2777491 0.957 rs316614 chr15:41746625 A/G cg18705301 chr15:41695430 NDUFAF1 -0.74 -12.82 -0.58 8.34e-31 Ulcerative colitis; CRC cis rs274567 0.501 rs272856 chr5:131687081 G/C cg04518342 chr5:131593106 PDLIM4 0.43 6.82 0.35 4.33e-11 Blood metabolite levels; CRC cis rs870825 0.929 rs871254 chr4:185589226 G/C cg07424746 chr4:185654737 MLF1IP -0.59 -5.7 -0.3 2.61e-8 Blood protein levels; CRC cis rs9287719 0.781 rs6714795 chr2:10759134 C/T cg00105475 chr2:10696890 NA 0.45 7.12 0.37 6.81e-12 Prostate cancer; CRC cis rs25422 0.938 rs114309775 chr6:118838782 G/A cg10217327 chr6:118973057 C6orf204 0.51 5.81 0.3 1.5e-8 Renal cell carcinoma; CRC trans rs11039798 1.000 rs8188963 chr11:48685693 C/A cg03929089 chr4:120376271 NA 0.63 6.06 0.32 3.73e-9 Axial length; CRC cis rs7726839 0.540 rs3749618 chr5:602650 A/G cg17948913 chr5:572064 NA 0.51 5.87 0.31 1.07e-8 Obesity-related traits; CRC cis rs7726839 0.540 rs3749615 chr5:601485 C/T cg09021430 chr5:549028 NA -0.74 -8.39 -0.42 1.42e-15 Obesity-related traits; CRC cis rs17826219 0.706 rs9893922 chr17:29068425 T/C cg13385521 chr17:29058706 SUZ12P 0.71 8.1 0.41 1.05e-14 Body mass index; CRC cis rs1865760 0.555 rs2051541 chr6:25945211 C/T cg12310025 chr6:25882481 NA 0.4 5.97 0.31 6.29e-9 Height; CRC cis rs780096 0.526 rs1260341 chr2:27663215 T/A cg17158414 chr2:27665306 KRTCAP3 -0.31 -6.75 -0.35 6.85e-11 Total body bone mineral density; CRC cis rs7412746 0.658 rs12097963 chr1:150870450 T/C cg15448220 chr1:150897856 SETDB1 0.56 8.19 0.41 6.03e-15 Melanoma; CRC trans rs728616 0.681 rs35420115 chr10:81908188 A/G cg18543242 chr14:23290393 SLC7A7 0.48 6.52 0.34 2.67e-10 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs2032447 0.765 rs1935235 chr6:26067782 C/G cg12588279 chr6:26043732 HIST1H2BB 0.43 6.09 0.32 3.07e-9 Intelligence (multi-trait analysis); CRC cis rs9462846 0.853 rs2395940 chr6:42860467 C/G cg21280719 chr6:42927975 GNMT -0.34 -6.53 -0.34 2.49e-10 Blood protein levels; CRC cis rs2479724 0.905 rs2274578 chr6:41888827 C/G cg17623882 chr6:41773611 USP49 -0.57 -9.61 -0.47 1.97e-19 Menarche (age at onset); CRC cis rs1865760 0.865 rs9393678 chr6:25945819 C/T cg16482183 chr6:26056742 HIST1H1C 0.52 7.37 0.38 1.41e-12 Height; CRC cis rs1799949 0.602 rs4600503 chr17:41414324 C/G cg05368731 chr17:41323189 NBR1 0.67 10.08 0.49 5.26e-21 Menopause (age at onset); CRC cis rs9467773 0.572 rs3846846 chr6:26445039 A/G cg09904177 chr6:26538194 HMGN4 -0.45 -6.28 -0.33 1.07e-9 Intelligence (multi-trait analysis); CRC cis rs9467773 0.967 rs1056347 chr6:26527524 G/C cg09904177 chr6:26538194 HMGN4 0.85 14.48 0.62 4.06e-37 Intelligence (multi-trait analysis); CRC cis rs9549367 0.789 rs9549711 chr13:113900557 C/T cg18105134 chr13:113819100 PROZ -0.74 -10.65 -0.51 6.16e-23 Platelet distribution width; CRC cis rs1218582 0.711 rs4845677 chr1:154838050 C/T cg24250549 chr1:154909240 PMVK 0.57 9.64 0.47 1.54e-19 Prostate cancer; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg15761814 chr2:109403565 CCDC138 0.42 6.09 0.32 3.07e-9 Intelligence (multi-trait analysis); CRC cis rs1799949 1.000 rs1545764 chr17:41424565 G/A cg05368731 chr17:41323189 NBR1 0.64 9.32 0.46 1.76e-18 Menopause (age at onset); CRC cis rs7827545 1.000 rs4909481 chr8:135564555 A/G cg07299736 chr8:135490787 ZFAT -0.37 -6.2 -0.32 1.73e-9 Hypertension (SNP x SNP interaction); CRC cis rs9372498 0.536 rs17424234 chr6:118808521 A/G cg07617317 chr6:118971624 C6orf204 0.47 5.66 0.3 3.25e-8 Diastolic blood pressure; CRC cis rs929354 0.806 rs28446734 chr7:156996775 T/C cg16102536 chr7:156981717 UBE3C 0.4 6.78 0.35 5.54e-11 Body mass index; CRC cis rs7811142 0.830 rs11765869 chr7:99964789 T/G cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.56 6.87 0.35 3.18e-11 Platelet count; CRC cis rs1707322 0.721 rs6699418 chr1:46100181 G/A cg06784218 chr1:46089804 CCDC17 0.63 11.78 0.54 5.67e-27 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs1153858 1.000 rs1554521 chr15:45664189 A/T cg14582100 chr15:45693742 SPATA5L1 -0.27 -5.62 -0.3 4.05e-8 Homoarginine levels; CRC cis rs6502050 0.835 rs8065556 chr17:80091176 G/C cg22110888 chr17:80059540 CCDC57 0.4 6.36 0.33 6.76e-10 Life satisfaction; CRC cis rs7923452 0.507 rs103441 chr10:30778184 C/T cg25182066 chr10:30743637 MAP3K8 -0.52 -6.77 -0.35 5.84e-11 Itch intensity from mosquito bite; CRC cis rs1218582 0.804 rs4845678 chr1:154853295 A/G cg06221963 chr1:154839813 KCNN3 -0.76 -15.58 -0.65 2.19e-41 Prostate cancer; CRC cis rs6479527 0.875 rs10429603 chr9:96805627 A/G cg14459158 chr9:96720562 NA 0.39 6.95 0.36 1.96e-11 Esophageal adenocarcinoma; CRC cis rs9902453 0.933 rs8080343 chr17:28456758 C/T cg26525008 chr17:28256777 EFCAB5;SSH2 0.6 9.56 0.47 2.92e-19 Coffee consumption (cups per day); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg18822411 chr15:40075102 FSIP1 0.36 5.98 0.31 5.8e-9 Liver disease severity in Alagille syndrome; CRC cis rs2839186 0.500 rs13052701 chr21:47660045 A/T cg00612595 chr21:47717864 NA -0.4 -6.36 -0.33 6.91e-10 Testicular germ cell tumor; CRC cis rs7666738 0.830 rs60007031 chr4:98824753 G/C cg17366294 chr4:99064904 C4orf37 0.43 6.89 0.36 2.79e-11 Colonoscopy-negative controls vs population controls; CRC trans rs2727020 0.734 rs1164664 chr11:49295542 T/G cg15704280 chr7:45808275 SEPT13 0.67 8.9 0.44 3.94e-17 Coronary artery disease; CRC cis rs10540 1.000 rs12421457 chr11:505780 T/C cg21784768 chr11:537496 LRRC56 -0.69 -6.56 -0.34 2.11e-10 Body mass index; CRC cis rs7224685 0.501 rs7211478 chr17:3897178 C/T cg09597638 chr17:3907349 NA 0.71 13.27 0.59 1.72e-32 Type 2 diabetes; CRC cis rs4862750 0.914 rs1863405 chr4:187874528 G/T cg22105103 chr4:187893119 NA -0.6 -10.94 -0.52 5.67e-24 Lobe attachment (rater-scored or self-reported); CRC cis rs7772486 0.558 rs702322 chr6:146007166 G/A cg05347473 chr6:146136440 FBXO30 -0.48 -6.9 -0.36 2.61e-11 Lobe attachment (rater-scored or self-reported); CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg00399650 chr7:141402322 KIAA1147 0.49 6.22 0.32 1.53e-9 Thyroid stimulating hormone; CRC cis rs1865760 1.000 rs6905887 chr6:25912103 T/C cg16482183 chr6:26056742 HIST1H1C 0.55 8.06 0.41 1.46e-14 Height; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg15057251 chr18:32621312 MAPRE2 0.4 6.05 0.32 3.91e-9 Intelligence (multi-trait analysis); CRC cis rs919433 0.680 rs788023 chr2:198283305 T/C cg10820045 chr2:198174542 NA 0.39 6.41 0.33 4.94e-10 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC cis rs908922 0.742 rs499913 chr1:152476743 T/A cg23254163 chr1:152506842 NA 0.39 6.65 0.34 1.21e-10 Hair morphology; CRC cis rs875971 1.000 rs12532998 chr7:65967459 A/C cg00343986 chr7:65444356 GUSB 0.44 6.48 0.34 3.42e-10 Aortic root size; CRC cis rs6681460 0.932 rs659291 chr1:67180746 A/C cg02459107 chr1:67143332 SGIP1 0.35 6.1 0.32 2.94e-9 Presence of antiphospholipid antibodies; CRC cis rs8014204 0.935 rs10141438 chr14:75354600 A/G cg03030879 chr14:75389066 RPS6KL1 0.54 8.83 0.44 6.45e-17 Caffeine consumption; CRC cis rs4862750 0.914 rs6553028 chr4:187876046 T/C cg22105103 chr4:187893119 NA 0.65 11.79 0.54 5.52e-27 Lobe attachment (rater-scored or self-reported); CRC cis rs8177253 0.965 rs3811658 chr3:133476852 C/T cg08048268 chr3:133502702 NA -0.36 -6.74 -0.35 7.31e-11 Iron status biomarkers; CRC cis rs1005277 0.579 rs9418322 chr10:38377296 G/T cg00409905 chr10:38381863 ZNF37A -0.67 -11.21 -0.53 6.28e-25 Extrinsic epigenetic age acceleration; CRC cis rs362272 0.545 rs2749785 chr4:3325179 G/C cg01612440 chr4:3296283 NA 0.4 5.62 0.3 4.11e-8 Serum sulfate level; CRC cis rs7552404 1.000 rs11163924 chr1:76132070 A/C cg10523679 chr1:76189770 ACADM -0.82 -11.21 -0.53 6.68e-25 Blood metabolite levels;Acylcarnitine levels; CRC cis rs9372498 0.536 rs17080292 chr6:118850266 A/G cg24463073 chr6:118973353 C6orf204 0.51 6.9 0.36 2.68e-11 Diastolic blood pressure; CRC cis rs11190604 1.000 rs10883504 chr10:102280687 G/A cg16342193 chr10:102329863 NA -0.38 -6.2 -0.32 1.66e-9 Palmitoleic acid (16:1n-7) levels; CRC cis rs9910055 0.676 rs11079983 chr17:42198170 C/T cg09913183 chr17:42254507 C17orf65;ASB16 0.57 8.25 0.41 3.79e-15 Total body bone mineral density; CRC cis rs11122272 0.735 rs2739515 chr1:231514681 G/A cg06096015 chr1:231504339 EGLN1 0.4 5.95 0.31 6.7e-9 Hemoglobin concentration; CRC cis rs3751196 0.808 rs56403068 chr12:104220743 T/C cg02344784 chr12:104178138 NT5DC3 0.71 7.28 0.37 2.55e-12 Sense of smell; CRC cis rs73206853 0.841 rs17187412 chr12:110766767 C/T cg12870014 chr12:110450643 ANKRD13A -0.8 -7.95 -0.4 3.1e-14 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC cis rs11122272 0.614 rs78172021 chr1:231525160 A/T cg06096015 chr1:231504339 EGLN1 0.4 5.98 0.31 5.78e-9 Hemoglobin concentration; CRC cis rs7845219 0.539 rs713113 chr8:95877787 C/T cg16049864 chr8:95962084 TP53INP1 0.52 8.65 0.43 2.34e-16 Type 2 diabetes; CRC cis rs11098499 0.863 rs6534139 chr4:120449456 A/G cg24375607 chr4:120327624 NA -0.45 -6.75 -0.35 6.79e-11 Corneal astigmatism; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg22302626 chr19:10196930 C19orf66 0.46 7.44 0.38 9.07e-13 Liver disease severity in Alagille syndrome; CRC cis rs7727544 0.904 rs6897575 chr5:131604535 C/T cg11843238 chr5:131593191 PDLIM4 0.34 6.6 0.34 1.68e-10 Blood metabolite levels; CRC cis rs2404602 0.679 rs12899871 chr15:76757347 T/C cg23625390 chr15:77176239 SCAPER 0.5 7.38 0.38 1.29e-12 Blood metabolite levels; CRC cis rs6502050 0.761 rs9908277 chr17:80060829 T/C cg22110888 chr17:80059540 CCDC57 -0.42 -6.57 -0.34 1.94e-10 Life satisfaction; CRC cis rs75422866 0.541 rs12425816 chr12:48125202 G/T cg14736327 chr12:48174669 SLC48A1 -0.77 -6.26 -0.33 1.22e-9 Pneumonia; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg03552472 chr10:51623769 TIMM23 0.37 6.18 0.32 1.86e-9 Liver disease severity in Alagille syndrome; CRC cis rs12594515 0.904 rs8032875 chr15:45998010 A/C cg06207120 chr15:45996521 NA 0.31 7.54 0.38 4.48e-13 Waist circumference;Weight; CRC cis rs1552244 1.000 rs6764168 chr3:10123805 A/G cg10729496 chr3:10149963 C3orf24 0.55 7.32 0.37 1.98e-12 Alzheimer's disease; CRC cis rs7647973 0.925 rs4955439 chr3:49245645 G/T cg07636037 chr3:49044803 WDR6 -0.56 -6.64 -0.34 1.33e-10 Menarche (age at onset); CRC cis rs6502050 0.835 rs7219138 chr17:80079896 C/T cg11859384 chr17:80120422 CCDC57 0.37 5.77 0.3 1.85e-8 Life satisfaction; CRC trans rs11098499 0.530 rs114866537 chr4:120258608 A/T cg25214090 chr10:38739885 LOC399744 0.55 9.0 0.44 1.84e-17 Corneal astigmatism; CRC cis rs2425143 0.643 rs6058324 chr20:34388789 G/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.49 -5.81 -0.3 1.51e-8 Blood protein levels; CRC cis rs3126085 0.877 rs6662450 chr1:152191709 C/G cg09127314 chr1:152161683 NA 0.52 6.81 0.35 4.79e-11 Atopic dermatitis; CRC cis rs35520189 0.591 rs6733003 chr2:113701452 G/A cg12858261 chr2:113808755 IL1F8 0.49 6.87 0.35 3.29e-11 Obstructive sleep apnea trait (apnea hypopnea index); CRC cis rs4481887 1.000 rs4474293 chr1:248470438 T/C cg00666640 chr1:248458726 OR2T12 0.52 9.2 0.45 4.1e-18 Common traits (Other); CRC cis rs1448094 0.511 rs7976647 chr12:86158766 A/G cg19622623 chr12:86230825 RASSF9 -0.37 -5.73 -0.3 2.24e-8 Major depressive disorder; CRC cis rs3096299 0.685 rs4329923 chr16:89560178 C/T cg00750074 chr16:89608354 SPG7 -0.48 -7.26 -0.37 2.83e-12 Multiple myeloma (IgH translocation); CRC cis rs4728302 0.869 rs6467510 chr7:133607968 A/G cg03336402 chr7:133662267 EXOC4 -0.44 -6.35 -0.33 7.31e-10 Intelligence;Intelligence (multi-trait analysis); CRC trans rs3780486 0.846 rs73484568 chr9:33132492 G/A cg20290983 chr6:43655470 MRPS18A 1.17 27.42 0.83 5.34e-87 IgG glycosylation; CRC cis rs501120 0.657 rs10899998 chr10:44688524 G/C cg09554077 chr10:44749378 NA 0.57 6.55 0.34 2.2e-10 Coronary artery disease;Coronary heart disease; CRC cis rs2836974 0.897 rs1571709 chr21:40553980 T/C cg11644478 chr21:40555479 PSMG1 0.84 13.43 0.6 4.32e-33 Cognitive function; CRC cis rs9322193 0.961 rs9027 chr6:149916057 T/A cg05861140 chr6:150128134 PCMT1 -0.41 -6.65 -0.34 1.21e-10 Lung cancer; CRC cis rs9911578 1.000 rs304270 chr17:56802141 A/G cg12560992 chr17:57184187 TRIM37 -0.9 -16.84 -0.68 2.61e-46 Intelligence (multi-trait analysis); CRC cis rs6502050 0.698 rs6502076 chr17:80121978 A/G cg02741985 chr17:80059408 CCDC57 0.43 7.15 0.37 5.59e-12 Life satisfaction; CRC cis rs17376456 0.825 rs34967135 chr5:93221785 G/A cg25358565 chr5:93447407 FAM172A 1.05 10.39 0.5 4.7e-22 Diabetic retinopathy; CRC cis rs5769765 0.773 rs9616206 chr22:50310847 G/T cg22709217 chr22:50311962 ALG12;CRELD2 -1.11 -18.13 -0.71 2.01e-51 Schizophrenia; CRC cis rs6502050 0.835 rs11658335 chr17:80084821 C/T cg11859384 chr17:80120422 CCDC57 0.37 5.82 0.31 1.36e-8 Life satisfaction; CRC cis rs1577917 0.958 rs2660576 chr6:86651603 T/A cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.51 -6.88 -0.35 3.08e-11 Response to antipsychotic treatment; CRC cis rs6969780 1.000 rs6969780 chr7:27159136 G/C cg26364809 chr7:27145159 NA -0.72 -6.69 -0.35 9.6e-11 Diastolic blood pressure;Blood pressure traits (multi-trait analysis);Systolic blood pressure;Hypertension; CRC cis rs1448094 0.556 rs17345522 chr12:86169929 T/C cg02569458 chr12:86230093 RASSF9 0.5 8.22 0.41 4.69e-15 Major depressive disorder; CRC cis rs10193935 0.901 rs9789740 chr2:42486799 A/G cg27598129 chr2:42591480 NA -0.7 -7.95 -0.4 2.96e-14 Colonoscopy-negative controls vs population controls; CRC cis rs9398803 0.865 rs9401883 chr6:126797111 A/G cg19875578 chr6:126661172 C6orf173 0.43 5.97 0.31 6.11e-9 Male-pattern baldness; CRC cis rs9911578 0.967 rs11079354 chr17:56594460 G/A cg12560992 chr17:57184187 TRIM37 -0.91 -17.1 -0.69 2.31e-47 Intelligence (multi-trait analysis); CRC cis rs853679 0.550 rs1150689 chr6:28165099 T/C cg15845792 chr6:28175446 NA 1.02 15.66 0.65 1.12e-41 Depression; CRC cis rs317689 0.690 rs604168 chr12:69671158 C/T cg14784868 chr12:69753453 YEATS4 0.44 5.71 0.3 2.54e-8 Response to diuretic therapy; CRC cis rs921968 0.509 rs626432 chr2:219355658 C/A cg02176678 chr2:219576539 TTLL4 0.54 8.69 0.43 1.78e-16 Mean corpuscular hemoglobin concentration; CRC cis rs10876993 0.928 rs1689592 chr12:58057773 C/T cg18357645 chr12:58087776 OS9 0.58 8.25 0.41 3.97e-15 Celiac disease or Rheumatoid arthritis; CRC cis rs7224685 0.501 rs1377806 chr17:4019966 A/G cg05562828 chr17:3906858 NA 0.63 11.4 0.53 1.4e-25 Type 2 diabetes; CRC cis rs225245 1.000 rs225245 chr17:33946107 A/G cg05299278 chr17:33885742 SLFN14 0.44 7.07 0.36 9.33e-12 Reticulocyte count;Reticulocyte fraction of red cells;High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells; CRC cis rs861020 0.771 rs654470 chr1:210014093 A/T cg09163369 chr1:210001066 C1orf107 0.63 8.34 0.42 2.12e-15 Orofacial clefts; CRC cis rs6445525 1.000 rs6805139 chr3:66005660 G/A cg06109867 chr3:66002991 MAGI1 -0.4 -6.49 -0.34 3.23e-10 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs763121 0.853 rs2267394 chr22:39101633 T/C cg06544989 chr22:39130855 UNC84B 0.48 7.6 0.39 3.18e-13 Menopause (age at onset); CRC cis rs1552244 0.572 rs113406084 chr3:10170190 T/C cg16606324 chr3:10149918 C3orf24 0.66 7.77 0.39 9.99e-14 Alzheimer's disease; CRC cis rs11148252 0.840 rs56304200 chr13:52781763 T/A cg00495681 chr13:53174319 NA 0.59 8.92 0.44 3.42e-17 Lewy body disease; CRC cis rs7927771 0.542 rs10769300 chr11:47865560 C/T cg20307385 chr11:47447363 PSMC3 0.45 6.62 0.34 1.48e-10 Subjective well-being; CRC cis rs10208940 0.920 rs35002937 chr2:68753240 T/A cg12452813 chr2:68675892 NA 0.48 6.05 0.32 4.01e-9 Urate levels in lean individuals; CRC cis rs8170 0.603 rs7249329 chr19:17423373 G/T cg14325436 chr19:17404977 ABHD8 -0.35 -5.7 -0.3 2.69e-8 Breast cancer (estrogen-receptor negative);Breast Cancer in BRCA1 mutation carriers;Ovarian cancer;Breast cancer;Epithelial ovarian cancer; CRC cis rs1559088 0.842 rs12977993 chr19:33580453 T/A cg03563238 chr19:33554763 RHPN2 -0.31 -5.63 -0.3 3.87e-8 Bone ultrasound measurement (broadband ultrasound attenuation); CRC cis rs3768617 1.000 rs12026314 chr1:183104527 A/G ch.1.3577855R chr1:183094577 LAMC1 0.62 9.7 0.47 9.55e-20 Fuchs's corneal dystrophy; CRC cis rs947211 1.000 rs823144 chr1:205744546 C/A cg07167872 chr1:205819463 PM20D1 0.42 5.83 0.31 1.34e-8 Parkinson's disease; CRC cis rs548181 0.668 rs540555 chr11:125486848 T/C cg03464685 chr11:125439445 EI24 1.08 11.38 0.53 1.56e-25 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs8177179 0.967 rs6782434 chr3:133438834 C/G cg17775713 chr3:133465469 TF 0.37 6.67 0.35 1.09e-10 Iron status biomarkers (transferrin levels); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg00677811 chr7:45040321 CCM2 0.45 6.17 0.32 2e-9 Response to antipsychotic treatment; CRC cis rs9348729 1 rs9348729 chr6:26664268 T/C cg12292205 chr6:26970375 C6orf41 -0.65 -7.64 -0.39 2.46e-13 Intelligence (multi-trait analysis); CRC cis rs6879260 0.963 rs1035412 chr5:179729328 C/T cg26918954 chr5:179728553 GFPT2 -0.42 -6.88 -0.35 2.95e-11 Height; CRC cis rs9522267 0.535 rs9522305 chr13:112237550 A/G cg14352298 chr13:112236639 NA 0.29 6.59 0.34 1.74e-10 Hepatitis; CRC trans rs10802346 0.545 rs1770012 chr1:246426405 A/G cg13514129 chr1:39547527 MACF1 0.68 10.35 0.5 6.3e-22 Fractional exhaled nitric oxide (childhood); CRC cis rs7255436 1.000 rs7255436 chr19:8433196 C/A cg16745616 chr19:8428856 ANGPTL4 -0.45 -6.94 -0.36 2.1e-11 HDL cholesterol; CRC cis rs2075371 0.674 rs11771785 chr7:134013249 A/G cg20476274 chr7:133979776 SLC35B4 -0.58 -8.73 -0.43 1.29e-16 Mean platelet volume; CRC cis rs10504229 0.683 rs7459925 chr8:58111771 G/A cg22535103 chr8:58192502 C8orf71 -0.7 -9.2 -0.45 4.33e-18 Developmental language disorder (linguistic errors); CRC cis rs10540 0.570 rs8176330 chr11:535798 G/A cg03352830 chr11:487213 PTDSS2 0.65 7.33 0.37 1.75e-12 Body mass index; CRC trans rs929596 0.517 rs1875263 chr2:234625622 C/T cg14520829 chr3:18390388 SATB1 0.44 6.67 0.35 1.11e-10 Total bilirubin levels in HIV-1 infection; CRC cis rs4664293 0.967 rs7597488 chr2:160547096 T/G cg08347373 chr2:160653686 CD302 -0.38 -6.18 -0.32 1.9e-9 Monocyte percentage of white cells; CRC cis rs881375 0.967 rs7034653 chr9:123687372 G/A cg14255062 chr9:123606675 PSMD5;LOC253039 0.4 5.89 0.31 9.38e-9 Rheumatoid arthritis; CRC cis rs11212617 0.967 rs172895 chr11:108265876 C/G cg01991180 chr11:108092276 ATM;NPAT 0.41 6.07 0.32 3.46e-9 Response to metformin in type 2 diabetes (glycemic); CRC cis rs9322193 0.884 rs880245 chr6:150167398 A/G cg13206674 chr6:150067644 NUP43 -0.65 -9.12 -0.45 7.85e-18 Lung cancer; CRC cis rs394563 0.591 rs6570963 chr6:149691355 T/G cg03678062 chr6:149772716 ZC3H12D 0.34 6.21 0.32 1.64e-9 Dupuytren's disease; CRC cis rs6502050 0.835 rs7503111 chr17:80101587 A/T cg09264619 chr17:80180166 NA -0.34 -5.81 -0.3 1.5e-8 Life satisfaction; CRC cis rs4076764 0.522 rs10799914 chr1:163353205 A/G cg06092702 chr1:163392909 NA -0.39 -6.01 -0.31 4.84e-9 Motion sickness; CRC cis rs1971762 0.583 rs1864448 chr12:54087856 T/G cg06632207 chr12:54070931 ATP5G2 0.39 6.59 0.34 1.75e-10 Height; CRC cis rs875971 0.830 rs6976714 chr7:65891461 G/A cg00343986 chr7:65444356 GUSB 0.42 5.84 0.31 1.26e-8 Aortic root size; CRC trans rs10875746 0.855 rs12296244 chr12:48441479 C/G cg08231274 chr14:57735852 MUDENG;EXOC5 -0.58 -6.07 -0.32 3.52e-9 Longevity (90 years and older); CRC cis rs4654899 0.643 rs589755 chr1:21099846 A/G cg02927042 chr1:21476669 EIF4G3 -0.38 -5.9 -0.31 8.85e-9 Superior frontal gyrus grey matter volume; CRC cis rs897984 0.542 rs6565217 chr16:31083324 C/T cg02466173 chr16:30829666 NA -0.64 -10.21 -0.49 1.95e-21 Dementia with Lewy bodies; CRC cis rs4819052 0.851 rs28501512 chr21:46676702 C/T cg19498844 chr21:46707878 POFUT2;LOC642852 0.77 11.19 0.52 7.85e-25 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs1853665 0.580 rs12524576 chr6:150271944 G/A cg16301758 chr6:150275521 NA -0.39 -5.77 -0.3 1.85e-8 Radiation response; CRC cis rs1008375 1.000 rs4698199 chr4:17656738 G/C cg04450456 chr4:17643702 FAM184B 0.41 6.59 0.34 1.79e-10 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs4268898 0.662 rs2891382 chr2:24511491 C/G cg06627628 chr2:24431161 ITSN2 -0.81 -11.3 -0.53 3.02e-25 Asthma; CRC cis rs12477438 0.520 rs12621007 chr2:99791946 G/C cg14399236 chr2:99771627 LIPT1;TSGA10 0.82 14.55 0.63 2.26e-37 Chronic sinus infection; CRC trans rs11712655 0.961 rs3937966 chr3:135226700 C/T cg14625040 chr2:6214447 NA -0.41 -6.09 -0.32 3.21e-9 Visceral adipose tissue/subcutaneous adipose tissue ratio; CRC cis rs7086627 0.515 rs2125040 chr10:82208422 G/C cg00277334 chr10:82204260 NA -0.84 -16.96 -0.68 8.63e-47 Post bronchodilator FEV1; CRC cis rs7618915 0.547 rs34610142 chr3:52708429 G/A cg08222913 chr3:52553049 STAB1 -0.34 -6.12 -0.32 2.7e-9 Bipolar disorder; CRC cis rs2882667 0.690 rs288040 chr5:138204894 A/T cg09476006 chr5:138032270 NA 0.54 8.92 0.44 3.21e-17 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs1355223 0.583 rs2915177 chr11:34880266 A/G cg24088639 chr11:34937564 PDHX;APIP -0.59 -8.59 -0.43 3.52e-16 Systemic lupus erythematosus and Systemic sclerosis; CRC cis rs7894051 1.000 rs7074435 chr10:135190570 G/T cg20534287 chr10:135191450 PAOX 0.69 6.19 0.32 1.78e-9 Lifespan; CRC cis rs709400 0.663 rs17617941 chr14:103953032 T/C cg12935359 chr14:103987150 CKB -0.53 -8.22 -0.41 4.75e-15 Body mass index; CRC cis rs9976767 0.932 rs9978717 chr21:43827765 A/G cg23042151 chr21:43824109 UBASH3A -0.37 -6.41 -0.33 4.98e-10 Type 1 diabetes; CRC cis rs12802200 0.535 rs35541591 chr11:570538 C/A cg16486109 chr11:613632 IRF7 0.59 10.42 0.5 3.57e-22 Systemic lupus erythematosus; CRC trans rs2727020 0.521 rs11039902 chr11:48679467 A/G cg21153622 chr11:89784906 NA -0.52 -8.67 -0.43 2.07e-16 Coronary artery disease; CRC cis rs9921222 0.500 rs11645742 chr16:367516 C/T cg12437481 chr16:420112 MRPL28 -0.62 -7.97 -0.4 2.61e-14 Bone mineral density (spine);Bone mineral density; CRC cis rs514406 0.861 rs7524476 chr1:53240212 C/T cg24675658 chr1:53192096 ZYG11B 0.56 8.12 0.41 9.27e-15 Monocyte count; CRC cis rs4363385 0.818 rs679378 chr1:153011716 G/A cg25856811 chr1:152973957 SPRR3 -0.25 -6.81 -0.35 4.67e-11 Inflammatory skin disease; CRC cis rs10504229 0.728 rs17215851 chr8:58154160 A/C cg11062466 chr8:58055876 NA 0.45 6.11 0.32 2.74e-9 Developmental language disorder (linguistic errors); CRC cis rs9826463 0.582 rs114066728 chr3:142022265 T/C cg20824294 chr3:142316082 PLS1 0.36 5.72 0.3 2.38e-8 QRS duration in Tripanosoma cruzi seropositivity; CRC cis rs7613875 0.600 rs2247510 chr3:50126215 A/C cg05623727 chr3:50126028 RBM5 0.59 10.14 0.49 3.45e-21 Body mass index; CRC cis rs1760803 0.754 rs12062977 chr1:154211516 C/T cg26808167 chr1:154192205 UBAP2L;C1orf43 -0.34 -5.94 -0.31 7.2e-9 Nicotine dependence; CRC cis rs6604026 0.740 rs10782946 chr1:93352669 G/A cg17283838 chr1:93427260 FAM69A -0.5 -6.89 -0.35 2.9e-11 Multiple sclerosis; CRC cis rs8005677 0.828 rs8016027 chr14:23420153 T/C cg25600027 chr14:23388339 RBM23 -0.42 -6.2 -0.32 1.7e-9 Cognitive ability (multi-trait analysis); CRC cis rs281302 0.621 rs406196 chr15:47731245 A/G cg13159054 chr15:47721715 NA -0.43 -6.45 -0.34 3.93e-10 Educational attainment (years of education);Cognitive ability (multi-trait analysis); CRC cis rs4889855 0.530 rs8072592 chr17:78615361 A/C cg16591659 chr17:78472290 NA 0.42 6.12 0.32 2.64e-9 Fractional excretion of uric acid; CRC cis rs7487075 0.786 rs12298619 chr12:46673501 G/A cg22049899 chr12:47219821 SLC38A4 0.32 5.77 0.3 1.84e-8 Itch intensity from mosquito bite; CRC cis rs853679 0.517 rs17711344 chr6:28077602 A/G cg12273811 chr6:28175739 NA -0.72 -9.19 -0.45 4.49e-18 Depression; CRC cis rs1048238 0.846 rs945422 chr1:16345619 T/C cg24140574 chr1:16342155 HSPB7 0.44 6.31 0.33 9.2e-10 Systolic blood pressure; CRC cis rs6997458 0.742 rs10111039 chr8:86396656 G/A cg21346043 chr8:86351067 CA3 -0.28 -6.14 -0.32 2.43e-9 Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; CRC cis rs6674970 0.933 rs11204772 chr1:151056305 C/T cg03258749 chr1:151040405 MLLT11 -0.47 -7.28 -0.37 2.55e-12 Childhood ear infection; CRC cis rs3862260 0.509 rs3795662 chr1:120165135 G/T cg16322792 chr1:120165303 ZNF697 0.47 8.16 0.41 7.34e-15 Systemic lupus erythematosus; CRC trans rs6703335 0.870 rs10803142 chr1:243598234 A/G cg16794633 chr3:143690145 C3orf58 0.45 6.38 0.33 5.96e-10 Schizophrenia;Schizophrenia, schizoaffective disorder or bipolar disorder; CRC trans rs2228479 0.850 rs11640209 chr16:89807828 C/A cg24644049 chr4:85504048 CDS1 0.9 7.41 0.38 1.05e-12 Skin colour saturation; CRC cis rs1448094 0.845 rs17354637 chr12:86347752 A/G cg25456477 chr12:86230367 RASSF9 0.34 5.81 0.31 1.48e-8 Major depressive disorder; CRC cis rs669446 0.562 rs4660260 chr1:44195353 A/G cg12908607 chr1:44402522 ARTN -0.33 -5.79 -0.3 1.61e-8 Amyotrophic lateral sclerosis (age of onset); CRC cis rs4713118 0.588 rs200994 chr6:27813813 A/C cg20933634 chr6:27740509 NA -0.63 -8.56 -0.43 4.35e-16 Parkinson's disease; CRC cis rs939574 0.512 rs10194278 chr2:220138408 C/T cg00496455 chr2:220118770 TUBA4A;TUBA4B 0.48 5.69 0.3 2.75e-8 Platelet distribution width; CRC cis rs10504229 1.000 rs56740825 chr8:58175617 A/G cg01721255 chr8:58191610 C8orf71 0.49 6.17 0.32 2e-9 Developmental language disorder (linguistic errors); CRC cis rs6088813 1.000 rs6087703 chr20:33996433 T/C cg14752227 chr20:34000481 UQCC -0.37 -5.66 -0.3 3.23e-8 Height; CRC cis rs11148252 0.740 rs9536052 chr13:52960709 C/G cg00495681 chr13:53174319 NA -0.52 -7.75 -0.39 1.13e-13 Lewy body disease; CRC cis rs12908161 0.683 rs12903256 chr15:85308141 G/T cg17507749 chr15:85114479 UBE2QP1 0.53 7.76 0.39 1.06e-13 Schizophrenia; CRC cis rs2278034 0.502 rs3747672 chr3:195612034 T/C cg01181863 chr3:195395398 SDHAP2 -0.69 -9.96 -0.48 1.32e-20 Bronchopulmonary dysplasia; CRC cis rs7917772 0.503 rs11191347 chr10:104351617 C/T cg22532475 chr10:104410764 TRIM8 -0.36 -6.65 -0.34 1.25e-10 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC cis rs727505 1.000 rs10228201 chr7:124449895 A/G cg14311320 chr7:124405732 GPR37 -0.38 -5.65 -0.3 3.56e-8 Lewy body disease; CRC cis rs10504229 0.636 rs77753517 chr8:58115897 C/T cg02725872 chr8:58115012 NA -0.64 -11.55 -0.54 3.85e-26 Developmental language disorder (linguistic errors); CRC trans rs7267979 0.932 rs6138588 chr20:25487523 C/T cg17903999 chr18:56338584 MALT1 -0.41 -6.82 -0.35 4.3e-11 Liver enzyme levels (alkaline phosphatase); CRC cis rs4731207 0.698 rs4311608 chr7:124519707 T/C cg23710748 chr7:124431027 NA -0.38 -6.08 -0.32 3.42e-9 Cutaneous malignant melanoma; CRC cis rs9837602 0.507 rs793448 chr3:99532949 G/C cg07805332 chr3:99536008 MIR548G;C3orf26 0.52 7.77 0.39 1.01e-13 Breast cancer; CRC cis rs1580019 0.961 rs1868777 chr7:32494076 C/T cg07520158 chr7:32535189 LSM5;AVL9 0.4 5.86 0.31 1.12e-8 Cognitive ability; CRC trans rs2270927 0.510 rs35966882 chr5:75577716 A/G cg13563193 chr19:33072644 PDCD5 0.73 6.82 0.35 4.32e-11 Mean corpuscular volume; CRC cis rs9393692 0.905 rs7761298 chr6:26278436 C/T cg00631329 chr6:26305371 NA -0.68 -13.44 -0.6 3.92e-33 Educational attainment; CRC cis rs4901869 0.897 rs12878587 chr14:59339378 C/G cg02291164 chr14:59296302 NA 0.36 6.67 0.35 1.09e-10 Panic disorder; CRC cis rs514406 0.895 rs1925673 chr1:53326984 T/G cg27535305 chr1:53392650 SCP2 -0.37 -6.77 -0.35 5.99e-11 Monocyte count; CRC cis rs1153858 1.000 rs2056493 chr15:45648272 A/G cg10760299 chr15:45669010 GATM 0.51 8.16 0.41 7.22e-15 Homoarginine levels; CRC cis rs916888 0.773 rs199534 chr17:44824213 T/G cg15921436 chr17:44337874 NA 0.81 8.3 0.42 2.64e-15 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs7517126 1.000 rs7547477 chr1:196839292 C/T cg13682187 chr1:196946512 CFHR5 -0.36 -5.92 -0.31 7.89e-9 Blood protein levels; CRC cis rs7098414 0.511 rs7907575 chr10:82152675 T/G cg00277334 chr10:82204260 NA -0.48 -7.74 -0.39 1.23e-13 Post bronchodilator FEV1; CRC cis rs798554 0.836 rs13243214 chr7:2817455 G/T cg04166393 chr7:2884313 GNA12 0.5 6.62 0.34 1.5e-10 Height; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg26634140 chr19:9938264 UBL5 0.43 5.98 0.31 5.73e-9 Response to antipsychotic treatment; CRC cis rs13217239 0.646 rs11756275 chr6:27007113 A/C cg12292205 chr6:26970375 C6orf41 -0.52 -8.5 -0.42 6.54e-16 Schizophrenia; CRC cis rs2072499 0.931 rs1052053 chr1:156202173 A/G cg25208724 chr1:156163844 SLC25A44 0.98 20.92 0.76 2.16e-62 Testicular germ cell tumor; CRC cis rs1799949 1.000 rs2175957 chr17:41286822 T/G cg23758822 chr17:41437982 NA 0.8 13.67 0.6 5.4400000000000004e-34 Menopause (age at onset); CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg10651300 chr12:53661859 ESPL1 0.55 7.24 0.37 3.16e-12 Thyroid stimulating hormone; CRC cis rs12142240 0.698 rs72677587 chr1:46813982 G/A cg00530320 chr1:46809349 NSUN4 0.58 7.81 0.4 7.54e-14 Menopause (age at onset); CRC trans rs1005277 0.522 rs200943 chr10:38148730 A/G cg27523141 chr10:43048294 ZNF37B 0.45 6.59 0.34 1.7e-10 Extrinsic epigenetic age acceleration; CRC cis rs7208859 0.623 rs7220999 chr17:29149298 C/T cg19761014 chr17:28927070 LRRC37B2 0.58 5.85 0.31 1.16e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs877282 0.853 rs12763400 chr10:763617 C/T cg17470449 chr10:769945 NA 0.65 8.51 0.42 6.25e-16 Uric acid levels; CRC cis rs853679 0.546 rs34295134 chr6:27828151 T/A cg19041857 chr6:27730383 NA -0.71 -6.81 -0.35 4.66e-11 Depression; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg09667226 chr13:73632762 KLF5 0.43 6.26 0.33 1.18e-9 Response to antipsychotic treatment; CRC cis rs2762353 0.779 rs1408273 chr6:25840946 C/T cg12310025 chr6:25882481 NA 0.44 6.72 0.35 7.92e-11 Blood metabolite levels; CRC cis rs13082711 0.911 rs3736312 chr3:27442336 G/A cg02860705 chr3:27208620 NA 0.61 8.64 0.43 2.43e-16 Systolic blood pressure;Diastolic blood pressure;Blood pressure; CRC cis rs7772486 0.720 rs4896844 chr6:146075224 T/C cg05347473 chr6:146136440 FBXO30 -0.39 -5.84 -0.31 1.26e-8 Lobe attachment (rater-scored or self-reported); CRC cis rs3093024 0.904 rs3093019 chr6:167539655 C/G cg07513332 chr6:167530253 CCR6 -0.44 -8.11 -0.41 1.04e-14 Rheumatoid arthritis; CRC cis rs524281 0.861 rs10896087 chr11:65924549 A/G cg16950941 chr11:66035639 RAB1B -0.6 -7.43 -0.38 9.29e-13 Electroencephalogram traits; CRC cis rs10191773 0.589 rs11676628 chr2:112953355 A/G cg24977338 chr2:113188963 RGPD8;RGPD5 0.58 5.82 0.31 1.42e-8 Yeast infection; CRC cis rs34172651 0.917 rs1465422 chr16:24772486 C/T cg06505273 chr16:24850292 NA 0.39 6.01 0.31 5.04e-9 Intelligence (multi-trait analysis); CRC cis rs9926296 0.605 rs12448860 chr16:89849629 T/A cg27121462 chr16:89883253 FANCA 0.58 9.32 0.46 1.8e-18 Vitiligo; CRC cis rs6061231 0.798 rs2427308 chr20:60969451 C/T cg24112000 chr20:60950667 NA -0.59 -9.01 -0.44 1.74e-17 Colorectal cancer; CRC cis rs6961069 0.837 rs1722505 chr7:80240689 T/C cg04458919 chr7:80252533 CD36 -0.36 -6.4 -0.33 5.28e-10 Platelet count; CRC cis rs977987 0.806 rs11641587 chr16:75464419 G/T cg03315344 chr16:75512273 CHST6 0.55 9.12 0.45 7.56e-18 Dupuytren's disease; CRC cis rs875971 0.862 rs6962717 chr7:65883735 G/A cg00343986 chr7:65444356 GUSB 0.41 5.87 0.31 1.09e-8 Aortic root size; CRC cis rs3820068 0.581 rs72645874 chr1:15926238 C/G cg13390004 chr1:15929781 NA 0.5 7.09 0.36 8.36e-12 Systolic blood pressure; CRC cis rs12024301 0.557 rs2231240 chr1:183599638 C/T cg11505048 chr1:183622726 RGL1;APOBEC4 0.76 6.93 0.36 2.16e-11 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs875971 0.964 rs778721 chr7:65845397 C/G cg18912574 chr7:65842487 NCRNA00174 0.36 6.18 0.32 1.88e-9 Aortic root size; CRC cis rs17376456 0.825 rs17372725 chr5:93135588 C/A cg25358565 chr5:93447407 FAM172A 1.01 10.23 0.49 1.67e-21 Diabetic retinopathy; CRC cis rs932541 0.955 rs6105611 chr20:16457351 C/T cg17003395 chr20:16555519 KIF16B 0.41 5.63 0.3 3.82e-8 Intelligence; CRC cis rs2019137 0.539 rs4849177 chr2:113982584 T/C cg21550016 chr2:113992930 PAX8;LOC440839;LOC654433 0.66 10.17 0.49 2.56e-21 Lymphocyte counts; CRC cis rs9910055 0.509 rs9916444 chr17:42313512 C/G cg10896456 chr17:42255109 ASB16;C17orf65 0.33 5.71 0.3 2.48e-8 Total body bone mineral density; CRC cis rs35146811 0.735 rs2272345 chr7:99797031 C/G cg00553149 chr7:99775558 STAG3;GPC2 0.24 5.77 0.3 1.82e-8 Coronary artery disease; CRC cis rs9322193 0.962 rs7740784 chr6:150154500 C/T cg04369109 chr6:150039330 LATS1 -0.44 -5.67 -0.3 3.17e-8 Lung cancer; CRC trans rs1814175 0.935 rs7479914 chr11:49661351 T/C cg15704280 chr7:45808275 SEPT13 -0.98 -18.37 -0.71 2.25e-52 Height; CRC cis rs6484504 0.576 rs11031320 chr11:31242545 C/T cg14844989 chr11:31128820 NA -0.34 -6.0 -0.31 5.16e-9 Red blood cell count; CRC cis rs7208859 0.673 rs8077116 chr17:29140162 A/G cg01831904 chr17:28903510 LRRC37B2 -0.62 -6.41 -0.33 5.13e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs7224685 0.501 rs781845 chr17:3958341 A/G cg21851534 chr17:3907994 ZZEF1 -0.38 -6.57 -0.34 1.93e-10 Type 2 diabetes; CRC cis rs897984 0.762 rs4889599 chr16:30968589 C/T cg00531865 chr16:30841666 NA 0.47 6.77 0.35 5.97e-11 Dementia with Lewy bodies; CRC cis rs875971 0.862 rs28470208 chr7:65584700 A/G cg00343986 chr7:65444356 GUSB -0.41 -5.87 -0.31 1.06e-8 Aortic root size; CRC cis rs2228479 0.702 rs17177891 chr16:89799950 C/T cg19635926 chr16:89946313 TCF25 0.68 6.13 0.32 2.57e-9 Skin colour saturation; CRC cis rs727505 1.000 rs56356267 chr7:124557549 A/G cg23710748 chr7:124431027 NA -0.8 -14.11 -0.61 1.15e-35 Lewy body disease; CRC cis rs698813 0.724 rs1067364 chr2:44655734 A/G cg04920474 chr2:44395004 PPM1B 0.44 6.03 0.32 4.29e-9 Adverse response to chemotherapy in breast cancer (alopecia) (paclitaxel); CRC trans rs12566888 1 rs12566888 chr1:156869047 G/T cg00735843 chr14:57735967 MUDENG;EXOC5 0.54 5.97 0.31 6.31e-9 Platelet aggregation; CRC cis rs898097 0.841 rs9896263 chr17:80902741 A/G cg03160526 chr17:80928410 B3GNTL1 0.45 6.62 0.34 1.45e-10 Breast cancer; CRC cis rs9292777 0.720 rs4957286 chr5:40418521 A/G cg09067459 chr5:40385259 NA -0.55 -8.93 -0.44 3.12e-17 Crohn's disease;Multiple sclerosis; CRC cis rs832540 0.806 rs10039322 chr5:56260259 A/C cg12311346 chr5:56204834 C5orf35 -0.44 -6.86 -0.35 3.47e-11 Coronary artery disease; CRC cis rs863345 0.535 rs12064570 chr1:158499631 T/C cg12129480 chr1:158549410 OR10X1 -0.3 -6.18 -0.32 1.88e-9 Pneumococcal bacteremia; CRC cis rs4722166 0.532 rs1880242 chr7:22759607 A/C cg05472934 chr7:22766657 IL6 -0.64 -10.01 -0.48 9.1e-21 Lung cancer; CRC cis rs7927771 0.864 rs755553 chr11:47432303 G/A cg20307385 chr11:47447363 PSMC3 0.6 8.99 0.44 2.05e-17 Subjective well-being; CRC trans rs4386084 1.000 rs62020967 chr15:50256059 T/C cg02453146 chr1:53068587 GPX7 -0.34 -5.97 -0.31 6.13e-9 Basophil percentage of white cells;Basophil percentage of granulocytes; CRC cis rs1256061 0.624 rs7229 chr14:64692825 G/A cg23250157 chr14:64679961 SYNE2 0.45 7.04 0.36 1.14e-11 Hemoglobin concentration;Red blood cell count;Hematocrit; CRC cis rs11958404 0.932 rs55943686 chr5:157439591 G/C cg05962755 chr5:157440814 NA 1.01 12.88 0.58 5.12e-31 IgG glycosylation; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg08151832 chr16:66835414 CCDC79 -0.37 -6.2 -0.32 1.67e-9 Liver disease severity in Alagille syndrome; CRC cis rs853679 0.517 rs1853097 chr6:28058635 A/G cg23161317 chr6:28129485 ZNF389 0.52 6.35 0.33 6.97e-10 Depression; CRC cis rs561341 1.000 rs72823789 chr17:30284084 G/A cg23018236 chr17:30244563 NA -0.65 -7.74 -0.39 1.21e-13 Hip circumference adjusted for BMI; CRC cis rs883565 0.527 rs11715262 chr3:39003853 A/T cg01426195 chr3:39028469 NA -0.41 -6.87 -0.35 3.31e-11 Handedness; CRC cis rs2882667 0.894 rs10054478 chr5:138354075 G/A cg09476006 chr5:138032270 NA 0.41 6.86 0.35 3.4e-11 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs2692947 0.589 rs810057 chr2:97015073 T/C cg23100626 chr2:96804247 ASTL 0.28 7.1 0.36 7.68e-12 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; CRC cis rs2882667 0.627 rs1549203 chr5:138468344 A/G cg04439458 chr5:138467593 SIL1 0.35 6.44 0.33 4.13e-10 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs877282 0.947 rs4133015 chr10:774131 T/C cg17470449 chr10:769945 NA 0.6 8.7 0.43 1.64e-16 Uric acid levels; CRC cis rs9346649 0.630 rs4235913 chr6:168491697 T/C cg02770688 chr6:168491649 NA 0.62 9.14 0.45 6.49e-18 Venous thromboembolism adjusted for sickle cell variant rs77121243-T; CRC cis rs9910055 1.000 rs9895423 chr17:42285740 T/C cg09913183 chr17:42254507 C17orf65;ASB16 0.53 7.61 0.39 2.93e-13 Total body bone mineral density; CRC cis rs12142240 0.698 rs41294456 chr1:46809782 T/C cg14993813 chr1:46806288 NSUN4 -0.49 -6.22 -0.32 1.5e-9 Menopause (age at onset); CRC cis rs1348850 0.567 rs880899 chr2:178532416 A/G cg02961200 chr2:178257176 LOC100130691;AGPS 0.58 8.28 0.42 3.05e-15 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs2816062 0.813 rs2816044 chr1:18892826 A/G cg18795169 chr1:18902165 NA -0.92 -18.74 -0.72 7.88e-54 Urate levels in lean individuals; CRC trans rs877282 1.000 rs12219807 chr10:772870 A/C cg22713356 chr15:30763199 NA 1.16 14.75 0.63 3.65e-38 Uric acid levels; CRC cis rs11628318 0.570 rs2896450 chr14:103076595 T/C cg23461800 chr14:103021989 NA -0.7 -7.99 -0.4 2.27e-14 Platelet count; CRC cis rs780096 0.546 rs7563162 chr2:27631191 C/T cg24768116 chr2:27665128 KRTCAP3 -0.36 -8.13 -0.41 9.08e-15 Total body bone mineral density; CRC cis rs6088590 1.000 rs6120705 chr20:33313740 T/C cg08999081 chr20:33150536 PIGU 0.5 8.49 0.42 7.27e-16 Coronary artery disease; CRC cis rs2842992 0.872 rs1570318 chr6:160111473 C/T cg19482086 chr6:160211437 TCP1;MRPL18 0.69 8.6 0.43 3.33e-16 Age-related macular degeneration (geographic atrophy); CRC trans rs7395662 0.517 rs10454483 chr11:48754997 A/G cg00717180 chr2:96193071 NA -0.39 -6.42 -0.33 4.67e-10 HDL cholesterol; CRC cis rs4969178 0.930 rs7208596 chr17:76396528 C/G cg20026190 chr17:76395443 PGS1 0.4 6.2 0.32 1.73e-9 HDL cholesterol levels; CRC cis rs6724607 1.000 rs28452331 chr2:191471847 C/T cg10560079 chr2:191398806 TMEM194B -0.5 -7.21 -0.37 3.96e-12 Pulse pressure; CRC cis rs9928842 0.823 rs11149811 chr16:75300708 C/G cg09066997 chr16:75300724 BCAR1 0.64 5.91 0.31 8.68e-9 Alcoholic chronic pancreatitis; CRC cis rs1344694 0.566 rs4672790 chr2:216892446 C/T cg25588852 chr2:216877276 MREG -0.35 -6.86 -0.35 3.45e-11 Alcohol dependence; CRC cis rs4268898 0.662 rs9784114 chr2:24437517 C/T cg06627628 chr2:24431161 ITSN2 -0.85 -11.56 -0.54 3.46e-26 Asthma; CRC cis rs12630931 1.000 rs12630931 chr3:31981767 T/C cg21375017 chr3:31988082 OSBPL10 0.42 5.8 0.3 1.52e-8 Periodontal disease-related phenotypes; CRC cis rs875971 0.862 rs4718377 chr7:66049678 C/T cg18252515 chr7:66147081 NA 0.43 6.18 0.32 1.85e-9 Aortic root size; CRC cis rs2050392 0.792 rs303434 chr10:30714440 G/A cg18806716 chr10:30721971 MAP3K8 -0.49 -7.44 -0.38 8.6e-13 Inflammatory bowel disease; CRC cis rs832540 0.552 rs702681 chr5:56218029 C/T cg20203395 chr5:56204925 C5orf35 -0.44 -5.98 -0.31 5.78e-9 Coronary artery disease; CRC cis rs7666738 0.830 rs10028692 chr4:98962585 C/T cg05340658 chr4:99064831 C4orf37 0.61 9.45 0.46 6.55e-19 Colonoscopy-negative controls vs population controls; CRC cis rs3087591 0.922 rs12950506 chr17:29598392 A/G cg24425628 chr17:29625626 OMG;NF1 0.88 17.21 0.69 8.34e-48 Hip circumference; CRC cis rs11581903 0.568 rs11590859 chr1:53073838 G/T cg19751897 chr1:52520827 TXNDC12;BTF3L4 0.71 5.65 0.3 3.42e-8 Joint mobility (Beighton score); CRC cis rs7932354 0.583 rs7101374 chr11:46824241 G/A cg19486271 chr11:47235900 DDB2 -0.44 -6.53 -0.34 2.54e-10 Bone mineral density (hip);Bone mineral density; CRC cis rs2072499 0.966 rs2842865 chr1:156159532 G/A cg24450063 chr1:156163899 SLC25A44 1.15 27.61 0.84 1.1e-87 Testicular germ cell tumor; CRC cis rs853679 0.517 rs2281588 chr6:28072602 G/A cg25164649 chr6:28176230 NA 0.75 9.36 0.46 1.32e-18 Depression; CRC cis rs6460942 1.000 rs7791634 chr7:12401482 A/T cg06484146 chr7:12443880 VWDE -0.77 -7.65 -0.39 2.2e-13 Coronary artery disease; CRC cis rs7959452 0.640 rs12370042 chr12:69692420 C/G cg20891283 chr12:69753455 YEATS4 0.79 13.29 0.59 1.53e-32 Blood protein levels; CRC cis rs6933660 0.745 rs3778608 chr6:151738131 A/G cg10883421 chr6:151773342 RMND1;C6orf211 0.71 12.45 0.57 2.06e-29 Menarche (age at onset); CRC cis rs747650 0.892 rs7111764 chr11:47233209 G/A cg19486271 chr11:47235900 DDB2 -0.51 -7.79 -0.39 8.91e-14 Acne (severe); CRC cis rs367943 1.000 rs168366 chr5:112818587 C/T cg12552261 chr5:112820674 MCC 0.49 7.63 0.39 2.49e-13 Type 2 diabetes; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg10522587 chr1:120166026 ZNF697 -0.4 -6.58 -0.34 1.81e-10 Liver disease severity in Alagille syndrome; CRC cis rs769267 1.000 rs12985655 chr19:19442434 G/A cg20644253 chr19:19431407 KIAA0892;SF4 -0.41 -5.69 -0.3 2.78e-8 Tonsillectomy; CRC cis rs9462027 0.583 rs912716 chr6:34715761 A/G cg07306190 chr6:34760872 UHRF1BP1 -0.35 -6.24 -0.33 1.36e-9 Systemic lupus erythematosus; CRC cis rs7662987 0.517 rs1377689 chr4:100021787 A/G cg12011299 chr4:100065546 ADH4 0.49 9.27 0.46 2.46e-18 Smoking initiation; CRC cis rs9487051 0.735 rs396000 chr6:109519611 A/G cg21918786 chr6:109611834 NA 0.33 5.78 0.3 1.69e-8 Reticulocyte fraction of red cells; CRC trans rs75804782 0.641 rs56000747 chr2:239318541 T/G cg01134436 chr17:81009848 B3GNTL1 0.77 6.98 0.36 1.63e-11 Morning vs. evening chronotype;Chronotype; CRC cis rs13108904 0.870 rs12499546 chr4:1255194 C/T cg19318889 chr4:1322082 MAEA 0.41 5.95 0.31 6.97e-9 Obesity-related traits; CRC cis rs67311347 0.869 rs7646899 chr3:40366982 A/G cg09455208 chr3:40491958 NA 0.4 7.71 0.39 1.49e-13 Renal cell carcinoma; CRC cis rs7927592 0.956 rs11228277 chr11:68308324 G/A cg01657329 chr11:68192670 LRP5 -0.5 -7.66 -0.39 2.13e-13 Total body bone mineral density; CRC cis rs6088580 0.608 rs1205342 chr20:32921842 C/T cg08999081 chr20:33150536 PIGU -0.64 -12.0 -0.55 9.29e-28 Glomerular filtration rate (creatinine); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg07068998 chr1:115259668 NRAS;CSDE1 0.47 7.56 0.38 4.01e-13 Liver disease severity in Alagille syndrome; CRC trans rs12478296 1.000 rs7603984 chr2:243047294 A/G cg18288967 chr1:45987694 PRDX1 0.65 6.99 0.36 1.57e-11 Obesity-related traits; CRC cis rs9388451 0.531 rs9321057 chr6:126156943 G/A cg05901451 chr6:126070800 HEY2 -0.4 -5.86 -0.31 1.1e-8 Brugada syndrome; CRC cis rs3820928 0.605 rs10186145 chr2:227781150 A/G cg11843606 chr2:227700838 RHBDD1 -0.47 -7.26 -0.37 2.84e-12 Pulmonary function; CRC cis rs801193 0.935 rs2286683 chr7:66129843 G/A cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.44 -6.46 -0.34 3.75e-10 Aortic root size; CRC cis rs17376456 0.877 rs7734897 chr5:93305402 G/A cg09848695 chr5:92956644 FAM172A;MIR2277 0.64 5.92 0.31 8.24e-9 Diabetic retinopathy; CRC cis rs6540559 1.000 rs2073485 chr1:209962794 G/A cg22029157 chr1:209979665 IRF6 0.71 9.99 0.48 1.04e-20 Cleft lip with or without cleft palate; CRC cis rs62229266 0.804 rs2835231 chr21:37390598 C/T cg12218747 chr21:37451666 NA -0.43 -7.44 -0.38 8.61e-13 Mitral valve prolapse; CRC cis rs4665809 0.627 rs1465720 chr2:26412638 G/T cg08067268 chr2:26466485 HADHB;HADHA -0.67 -8.49 -0.42 7.3e-16 Gut microbiome composition (summer); CRC cis rs10503871 0.545 rs6468436 chr8:30469293 T/A cg26383811 chr8:30366931 RBPMS 0.39 5.62 0.3 4.05e-8 Metabolite levels (X-11787); CRC cis rs9733 0.565 rs11804276 chr1:150685761 T/A cg10589385 chr1:150898437 SETDB1 0.28 5.96 0.31 6.66e-9 Tonsillectomy; CRC cis rs7586879 0.796 rs916486 chr2:25082629 C/A cg22495460 chr2:25135724 ADCY3 -0.81 -13.5 -0.6 2.36e-33 Body mass index; CRC cis rs801193 0.569 rs2659908 chr7:66160822 G/A cg00343986 chr7:65444356 GUSB 0.45 6.21 0.32 1.56e-9 Aortic root size; CRC cis rs644799 1.000 rs693597 chr11:95589629 T/C cg03916912 chr11:95522834 CEP57;FAM76B 0.97 18.49 0.71 7.66e-53 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs73200209 0.744 rs41452748 chr12:116509432 A/T cg01776926 chr12:116560359 MED13L -0.67 -7.77 -0.39 1.03e-13 Total body bone mineral density; CRC cis rs1008375 1.000 rs2286771 chr4:17643848 G/A cg16339924 chr4:17578868 LAP3 0.58 7.9 0.4 4.3e-14 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs4665809 0.838 rs6546780 chr2:26352857 T/C cg26119090 chr2:26468346 HADHA;HADHB -0.6 -7.66 -0.39 2.05e-13 Gut microbiome composition (summer); CRC cis rs9435341 0.965 rs2335104 chr1:107583641 A/T cg09367891 chr1:107599246 PRMT6 0.63 9.78 0.47 5.41e-20 Facial morphology (factor 21, depth of nasal alae); CRC cis rs9467711 0.591 rs9467635 chr6:25909166 A/C cg08501292 chr6:25962987 TRIM38 1.0 9.67 0.47 1.2e-19 Autism spectrum disorder or schizophrenia; CRC cis rs6502050 0.805 rs7406858 chr17:80080623 G/A cg02741985 chr17:80059408 CCDC57 -0.44 -7.17 -0.37 4.96e-12 Life satisfaction; CRC cis rs3091242 0.933 rs926438 chr1:25753638 C/T cg27572855 chr1:25598939 RHD 0.32 5.71 0.3 2.52e-8 Erythrocyte sedimentation rate; CRC cis rs12431939 0.626 rs3924306 chr14:51715566 C/A cg23942311 chr14:51606299 NA 0.48 6.29 0.33 1.02e-9 Cancer; CRC cis rs720844 0.554 rs16828790 chr2:149296762 G/A cg09247360 chr2:149335327 NA -0.42 -5.7 -0.3 2.62e-8 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs4819052 0.679 rs4819053 chr21:46711357 C/T cg02159808 chr21:46707872 POFUT2;LOC642852 -0.44 -6.17 -0.32 2e-9 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs6831352 0.589 rs2924584 chr4:99988208 A/G cg13256891 chr4:100009986 ADH5 0.49 7.17 0.37 4.88e-12 Alcohol dependence; CRC cis rs35110281 0.693 rs11089093 chr21:45121161 C/T cg21573476 chr21:45109991 RRP1B -0.39 -5.93 -0.31 7.76e-9 Mean corpuscular volume; CRC cis rs10463316 0.894 rs13361316 chr5:150765593 T/C cg03212797 chr5:150827313 SLC36A1 -0.49 -7.7 -0.39 1.6e-13 Metabolite levels (Pyroglutamine); CRC cis rs6089584 0.566 rs6061972 chr20:60610245 C/T cg23463467 chr20:60627584 TAF4 0.42 7.74 0.39 1.25e-13 Body mass index; CRC cis rs1568889 0.838 rs7933991 chr11:28059761 T/C cg06544937 chr11:28130018 METT5D1;KIF18A 0.9 15.08 0.64 1.92e-39 Bipolar disorder; CRC cis rs274567 0.501 rs274571 chr5:131712125 A/G cg18758796 chr5:131593413 PDLIM4 -0.41 -6.61 -0.34 1.53e-10 Blood metabolite levels; CRC cis rs6723226 0.881 rs10181198 chr2:32686582 A/G cg02381751 chr2:32503542 YIPF4 0.6 8.49 0.42 7.42e-16 Intelligence (multi-trait analysis); CRC cis rs11229555 0.645 rs61905183 chr11:58228463 T/A cg15696309 chr11:58395628 NA -0.91 -11.54 -0.54 4.09e-26 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; CRC cis rs7552404 0.731 rs1770885 chr1:76402212 C/T cg10523679 chr1:76189770 ACADM -0.62 -7.8 -0.39 8.5e-14 Blood metabolite levels;Acylcarnitine levels; CRC cis rs10971721 0.822 rs117687546 chr9:33864929 G/A cg13495928 chr9:33750294 PRSS3 0.56 5.95 0.31 6.96e-9 Body mass index; CRC cis rs863345 0.967 rs10908685 chr1:158524436 T/A cg12129480 chr1:158549410 OR10X1 -0.26 -5.68 -0.3 2.9e-8 Pneumococcal bacteremia; CRC cis rs4803468 1.000 rs4674 chr19:41930396 A/G cg09537434 chr19:41945824 ATP5SL -0.97 -18.39 -0.71 1.96e-52 Height; CRC cis rs4731207 0.698 rs720615 chr7:124452706 C/T cg23710748 chr7:124431027 NA 0.38 6.08 0.32 3.42e-9 Cutaneous malignant melanoma; CRC cis rs548181 0.736 rs540436 chr11:125512619 A/G cg03464685 chr11:125439445 EI24 1.05 11.43 0.53 1.1e-25 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs4481887 1.000 rs4244179 chr1:248470984 T/A cg00666640 chr1:248458726 OR2T12 0.54 9.36 0.46 1.32e-18 Common traits (Other); CRC cis rs1800469 1.000 rs1800469 chr19:41860296 A/G cg08477640 chr19:41863820 B9D2 0.56 7.84 0.4 6.5e-14 Colorectal cancer; CRC cis rs35146811 0.625 rs2906645 chr7:99817859 A/G cg00553149 chr7:99775558 STAG3;GPC2 -0.25 -5.74 -0.3 2.16e-8 Coronary artery disease; CRC cis rs7224685 0.501 rs812996 chr17:3965674 T/C cg10724054 chr17:3904396 NA -0.48 -8.12 -0.41 9.44e-15 Type 2 diabetes; CRC cis rs13256369 0.901 rs13251887 chr8:8568678 G/A cg06671706 chr8:8559999 CLDN23 0.61 9.02 0.45 1.64e-17 Obesity-related traits; CRC cis rs7223966 1.000 rs7223966 chr17:61893398 G/A cg05941027 chr17:61774174 LIMD2 0.36 6.36 0.33 6.71e-10 Hip circumference adjusted for BMI;Body mass index; CRC cis rs4555082 0.874 rs2816613 chr14:105726367 C/T cg13114125 chr14:105738426 BRF1 -0.81 -11.69 -0.54 1.2e-26 Mean platelet volume;Platelet distribution width; CRC cis rs7927592 0.913 rs66752716 chr11:68273626 C/T cg01657329 chr11:68192670 LRP5 -0.46 -6.5 -0.34 2.97e-10 Total body bone mineral density; CRC cis rs514406 0.861 rs562182 chr1:53270010 C/T cg08859206 chr1:53392774 SCP2 -0.45 -6.9 -0.36 2.72e-11 Monocyte count; CRC cis rs12144094 0.882 rs55806106 chr1:120232539 T/A cg20995928 chr1:120229863 NA 0.47 6.47 0.34 3.56e-10 Height; CRC cis rs76878669 0.561 rs2236679 chr11:66108894 G/C cg18002602 chr11:66138449 SLC29A2 -0.3 -6.45 -0.33 4.11e-10 Educational attainment (years of education); CRC cis rs11122272 0.732 rs2808605 chr1:231540187 A/C cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.59 -8.84 -0.44 6.02e-17 Hemoglobin concentration; CRC cis rs6502050 0.835 rs12950475 chr17:80118924 T/C cg22110888 chr17:80059540 CCDC57 0.4 6.38 0.33 5.96e-10 Life satisfaction; CRC cis rs916888 0.773 rs199533 chr17:44828931 G/A cg15921436 chr17:44337874 NA 0.82 8.43 0.42 1.07e-15 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs929596 0.561 rs11891311 chr2:234639310 A/G cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 0.55 8.59 0.43 3.54e-16 Total bilirubin levels in HIV-1 infection; CRC cis rs501120 0.584 rs11238891 chr10:44670992 A/C cg09554077 chr10:44749378 NA -0.73 -8.09 -0.41 1.14e-14 Coronary artery disease;Coronary heart disease; CRC cis rs7712401 0.755 rs3756362 chr5:122108890 C/G cg18764291 chr5:122110994 SNX2 0.37 5.98 0.31 5.88e-9 Mean platelet volume; CRC cis rs3820068 0.603 rs59558854 chr1:15971399 T/G cg27534772 chr1:16042836 PLEKHM2 0.54 10.12 0.49 3.78e-21 Systolic blood pressure; CRC cis rs1552244 0.572 rs68121641 chr3:10165845 T/A cg10729496 chr3:10149963 C3orf24 0.48 5.61 0.3 4.19e-8 Alzheimer's disease; CRC cis rs4638749 0.677 rs2100407 chr2:108830188 G/C cg25838818 chr2:108905173 SULT1C2 -0.34 -5.71 -0.3 2.52e-8 Blood pressure; CRC cis rs4731207 0.698 rs34014883 chr7:124480577 C/T cg23710748 chr7:124431027 NA 0.38 6.08 0.32 3.42e-9 Cutaneous malignant melanoma; CRC cis rs10992471 0.756 rs10992303 chr9:95082804 A/G cg14631576 chr9:95140430 CENPP -0.4 -7.43 -0.38 9.69e-13 Visceral adipose tissue/subcutaneous adipose tissue ratio; CRC cis rs11608355 1.000 rs11066591 chr12:109880523 G/A cg19025524 chr12:109796872 NA -0.48 -6.87 -0.35 3.25e-11 Neuroticism; CRC cis rs7692995 1.000 rs6840868 chr4:17939331 C/T cg08925142 chr4:18023851 LCORL -0.52 -5.81 -0.31 1.45e-8 Height; CRC cis rs7677751 0.767 rs6832597 chr4:55076237 C/A cg00691999 chr4:55094011 PDGFRA 0.4 5.73 0.3 2.28e-8 Corneal astigmatism; CRC cis rs9291683 0.632 rs7679916 chr4:10042160 C/T cg11266682 chr4:10021025 SLC2A9 0.53 11.08 0.52 1.85e-24 Bone mineral density; CRC cis rs9322193 0.923 rs9800806 chr6:150061486 G/T cg05861140 chr6:150128134 PCMT1 -0.37 -5.89 -0.31 9.29e-9 Lung cancer; CRC cis rs898097 0.812 rs72859941 chr17:80837459 G/A cg16060761 chr17:80687452 NA 0.42 6.06 0.32 3.64e-9 Breast cancer; CRC trans rs7726839 0.540 rs4957080 chr5:644552 A/C cg25482853 chr8:67687455 SGK3 -1.11 -13.08 -0.58 8.83e-32 Obesity-related traits; CRC cis rs7918232 0.627 rs10829165 chr10:27319465 A/G cg14240646 chr10:27532245 ACBD5 -0.57 -6.61 -0.34 1.59e-10 Breast cancer; CRC cis rs4731207 0.596 rs9332427 chr7:124576958 C/T cg23710748 chr7:124431027 NA -0.39 -6.12 -0.32 2.67e-9 Cutaneous malignant melanoma; CRC cis rs9926296 0.656 rs7191144 chr16:89823393 C/T cg04287289 chr16:89883240 FANCA 0.54 8.5 0.42 6.67e-16 Vitiligo; CRC trans rs1814175 0.654 rs7482446 chr11:49779020 A/G cg11707556 chr5:10655725 ANKRD33B -0.42 -7.95 -0.4 3.05e-14 Height; CRC cis rs7927771 0.800 rs12146565 chr11:47398963 G/A cg20307385 chr11:47447363 PSMC3 -0.63 -8.97 -0.44 2.35e-17 Subjective well-being; CRC cis rs4547160 0.788 rs12227007 chr12:63484710 G/T cg26727693 chr12:63544175 AVPR1A -0.44 -8.32 -0.42 2.37e-15 Morning vs. evening chronotype; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg19747357 chr1:61547866 NFIA 0.5 7.16 0.37 5.39e-12 Response to antipsychotic treatment; CRC cis rs4925386 0.840 rs6143034 chr20:60920545 T/C cg24112000 chr20:60950667 NA -0.53 -8.51 -0.42 6.32e-16 Colorectal cancer;Colorectal cancer (SNP x SNP interaction); CRC cis rs921968 0.565 rs13408427 chr2:219628389 C/T cg02176678 chr2:219576539 TTLL4 -0.43 -6.85 -0.35 3.58e-11 Mean corpuscular hemoglobin concentration; CRC trans rs9784649 0.760 rs17343923 chr5:25052414 G/A cg08600765 chr20:34638493 LOC647979 -0.72 -9.18 -0.45 4.91e-18 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs17253792 0.822 rs7150841 chr14:56088986 T/C cg24579896 chr14:56047964 C14orf33;KTN1 0.71 5.69 0.3 2.81e-8 Putamen volume; CRC cis rs6499255 0.951 rs11075728 chr16:69611582 A/G cg04110750 chr16:69646130 NFAT5 -0.56 -7.57 -0.39 3.75e-13 IgE levels; CRC cis rs1552244 0.554 rs4488814 chr3:10002400 C/T cg18598329 chr3:10140678 FANCD2;C3orf24 0.52 7.48 0.38 6.75e-13 Alzheimer's disease; CRC trans rs2014572 0.510 rs8111661 chr19:57752326 C/G cg02674126 chr19:40336878 FBL -0.41 -6.39 -0.33 5.6e-10 Hyperactive-impulsive symptoms; CRC cis rs736801 0.740 rs12515180 chr5:131785684 C/T cg21138405 chr5:131827807 IRF1 -0.38 -6.58 -0.34 1.84e-10 Breast cancer;Mosquito bite size; CRC cis rs992157 0.710 rs12996912 chr2:219110555 A/G cg00012203 chr2:219082015 ARPC2 0.62 10.35 0.5 6.4e-22 Colorectal cancer; CRC cis rs9914988 0.943 rs11658884 chr17:27132742 A/G cg02049041 chr17:27085579 C17orf63 -0.45 -5.75 -0.3 1.99e-8 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs2549003 1.000 rs2070728 chr5:131819977 C/T cg21138405 chr5:131827807 IRF1 0.57 11.38 0.53 1.59e-25 Asthma (sex interaction); CRC cis rs11711311 1.000 rs12637066 chr3:113527574 A/G cg15478005 chr3:113465772 ATP6V1A;NAA50 0.43 5.96 0.31 6.36e-9 IgG glycosylation; CRC cis rs9733 0.544 rs2867302 chr1:150653650 T/C cg10589385 chr1:150898437 SETDB1 0.28 5.98 0.31 5.82e-9 Tonsillectomy; CRC cis rs9916302 0.904 rs2338755 chr17:37419317 C/T cg07936489 chr17:37558343 FBXL20 0.82 12.89 0.58 4.5e-31 Glomerular filtration rate (creatinine); CRC cis rs13082711 0.596 rs683503 chr3:27348094 C/T cg02860705 chr3:27208620 NA 0.49 7.3 0.37 2.17e-12 Systolic blood pressure;Diastolic blood pressure;Blood pressure; CRC cis rs4132509 1.000 rs2125230 chr1:243885848 A/G cg21452805 chr1:244014465 NA -0.49 -6.86 -0.35 3.47e-11 RR interval (heart rate); CRC cis rs11122272 0.735 rs2790890 chr1:231514567 C/T cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.52 -7.82 -0.4 7.45e-14 Hemoglobin concentration; CRC cis rs798554 0.567 rs2527695 chr7:2858267 T/G cg19717773 chr7:2847554 GNA12 -0.47 -7.99 -0.4 2.28e-14 Height; CRC cis rs7833790 0.926 rs72686467 chr8:82758929 T/G cg27398817 chr8:82754497 SNX16 0.57 6.82 0.35 4.48e-11 Diastolic blood pressure; CRC trans rs7647973 0.592 rs6774202 chr3:49687779 T/G cg21665057 chr3:196295764 WDR53;FBXO45 -0.62 -7.07 -0.36 9.14e-12 Menarche (age at onset); CRC cis rs11628318 0.802 rs2277471 chr14:103024387 A/C cg23071808 chr14:103021642 NA 0.59 7.73 0.39 1.3e-13 Platelet count; CRC cis rs929354 0.772 rs6459739 chr7:156998863 A/T cg05182265 chr7:156933206 UBE3C -0.76 -14.52 -0.62 3.01e-37 Body mass index; CRC cis rs1799949 1.000 rs1135214 chr17:41292323 T/C cg23758822 chr17:41437982 NA 0.8 13.44 0.6 3.93e-33 Menopause (age at onset); CRC cis rs9911578 0.967 rs302842 chr17:56728102 C/G cg12560992 chr17:57184187 TRIM37 0.91 16.63 0.68 1.66e-45 Intelligence (multi-trait analysis); CRC cis rs10979 0.838 rs12208649 chr6:143893321 G/T cg25407410 chr6:143891975 LOC285740 -0.84 -13.82 -0.61 1.45e-34 Hypospadias; CRC cis rs2629540 0.924 rs1545910 chr10:126428145 G/C cg08799069 chr10:126477246 METTL10 -0.66 -8.7 -0.43 1.6e-16 Cocaine dependence; CRC cis rs12762955 0.507 rs7095853 chr10:1040798 T/C cg20503657 chr10:835505 NA -0.48 -6.64 -0.34 1.3e-10 Response to angiotensin II receptor blocker therapy; CRC trans rs10411161 0.702 rs10423838 chr19:52387283 C/T cg22319618 chr22:45562946 NUP50 -0.57 -6.75 -0.35 6.83e-11 Breast cancer; CRC cis rs875971 0.545 rs4718348 chr7:65906576 A/G cg03233332 chr7:66118400 NA -0.43 -5.85 -0.31 1.18e-8 Aortic root size; CRC cis rs6546550 0.867 rs4401231 chr2:70063563 G/C cg02498382 chr2:70120550 SNRNP27 -0.49 -7.9 -0.4 4.3e-14 Prevalent atrial fibrillation; CRC cis rs7824557 0.527 rs2736296 chr8:11234844 G/A cg08071915 chr8:12219732 FAM66A 0.31 5.65 0.3 3.47e-8 Retinal vascular caliber; CRC cis rs6761276 0.934 rs11682107 chr2:113835522 G/A cg24553058 chr2:113831203 IL1F10 0.39 6.26 0.33 1.18e-9 Protein quantitative trait loci; CRC cis rs9611565 0.649 rs202614 chr22:41822150 A/C cg06634786 chr22:41940651 POLR3H 0.7 7.77 0.39 1.03e-13 Vitiligo; CRC cis rs1448094 0.544 rs56330110 chr12:86166666 A/G cg06740227 chr12:86229804 RASSF9 0.37 5.71 0.3 2.47e-8 Major depressive disorder; CRC cis rs7932354 0.550 rs2035068 chr11:46915993 T/C cg19486271 chr11:47235900 DDB2 -0.42 -6.38 -0.33 6.1e-10 Bone mineral density (hip);Bone mineral density; CRC cis rs2070488 0.775 rs2186457 chr3:38553965 A/G cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.7 11.69 0.54 1.28e-26 Electrocardiographic conduction measures; CRC cis rs4654899 0.772 rs10916892 chr1:21201325 A/G cg02927042 chr1:21476669 EIF4G3 -0.5 -7.57 -0.39 3.79e-13 Superior frontal gyrus grey matter volume; CRC cis rs9486719 1.000 rs926276 chr6:96868735 C/T cg06623918 chr6:96969491 KIAA0776 0.8 9.87 0.48 2.66e-20 Migraine;Coronary artery disease; CRC cis rs67311347 1.000 rs2085115 chr3:40497540 G/T cg09455208 chr3:40491958 NA 0.49 9.46 0.46 6.05e-19 Renal cell carcinoma; CRC cis rs7772486 0.846 rs1474871 chr6:146406294 G/A cg23711669 chr6:146136114 FBXO30 0.6 10.29 0.49 1.01e-21 Lobe attachment (rater-scored or self-reported); CRC cis rs17127169 0.536 rs74860172 chr1:65497547 T/A cg15583014 chr1:65468659 NA 0.89 6.12 0.32 2.71e-9 Sitting height ratio; CRC cis rs2032447 0.901 rs2213284 chr6:26031868 G/A cg27635394 chr6:26043820 HIST1H2BB 0.44 6.31 0.33 8.96e-10 Intelligence (multi-trait analysis); CRC trans rs11098499 0.863 rs11933966 chr4:120476715 G/A cg25214090 chr10:38739885 LOC399744 0.66 10.39 0.5 4.71e-22 Corneal astigmatism; CRC cis rs9457247 0.967 rs2015864 chr6:167381476 T/C cg23791538 chr6:167370224 RNASET2 0.38 5.97 0.31 6.08e-9 Crohn's disease; CRC cis rs870825 0.746 rs1107908 chr4:185620113 T/C cg04058563 chr4:185651563 MLF1IP 0.72 9.38 0.46 1.12e-18 Blood protein levels; CRC cis rs1799949 1.000 rs1060915 chr17:41234470 A/G cg05368731 chr17:41323189 NBR1 0.67 9.77 0.47 5.75e-20 Menopause (age at onset); CRC cis rs2243480 1.000 rs906134 chr7:65444288 G/C cg25985355 chr7:65971099 NA -0.49 -5.85 -0.31 1.19e-8 Diabetic kidney disease; CRC cis rs9902453 1.000 rs62070312 chr17:28438877 T/C cg26525008 chr17:28256777 EFCAB5;SSH2 0.58 8.74 0.43 1.17e-16 Coffee consumption (cups per day); CRC cis rs4664308 0.694 rs4665140 chr2:160890710 T/A cg03641300 chr2:160917029 PLA2R1 -0.55 -8.39 -0.42 1.48e-15 Idiopathic membranous nephropathy; CRC cis rs1799949 0.930 rs3092987 chr17:41222723 T/C cg23758822 chr17:41437982 NA 0.81 13.55 0.6 1.47e-33 Menopause (age at onset); CRC cis rs1707322 0.752 rs11211169 chr1:46166709 A/G cg03146154 chr1:46216737 IPP 0.67 9.73 0.47 7.77e-20 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs7945705 0.967 rs7123861 chr11:8892323 G/A cg14711859 chr11:8959438 ASCL3 -0.51 -8.24 -0.41 4.27e-15 Hemoglobin concentration; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg23162967 chr3:105587981 CBLB 0.38 6.34 0.33 7.43e-10 Liver disease severity in Alagille syndrome; CRC trans rs4918814 0.955 rs7090401 chr10:115107328 C/T cg25339052 chr2:196399403 NA -0.38 -5.99 -0.31 5.52e-9 Neuroticism (multi-trait analysis); CRC trans rs9545047 0.716 rs586219 chr13:79999312 T/C cg07061582 chr15:90234082 PEX11A;WDR93 -0.41 -5.97 -0.31 6.15e-9 Schizophrenia; CRC trans rs1005277 0.541 rs2263163 chr10:38389887 G/A cg17830980 chr10:43048298 ZNF37B -0.6 -9.93 -0.48 1.65e-20 Extrinsic epigenetic age acceleration; CRC cis rs853679 0.882 rs2743555 chr6:28241081 G/A cg15845792 chr6:28175446 NA 0.65 6.49 0.34 3.17e-10 Depression; CRC cis rs4929949 0.932 rs10840087 chr11:8616255 G/A cg20771178 chr11:8615675 STK33 0.35 5.77 0.3 1.81e-8 Body mass index; CRC cis rs67478160 0.643 rs8004408 chr14:104203938 G/A cg01849466 chr14:104193079 ZFYVE21 -0.5 -8.94 -0.44 2.84e-17 Schizophrenia; CRC trans rs60843830 1.000 rs17713396 chr2:227201 C/T cg11347411 chr7:150020925 ACTR3C;LRRC61 0.57 8.8 0.44 8.08e-17 Spherical equivalent (joint analysis main effects and education interaction); CRC cis rs9372498 0.536 rs7356947 chr6:118767920 A/G cg01339444 chr6:118972232 C6orf204 0.52 5.87 0.31 1.08e-8 Diastolic blood pressure; CRC cis rs2839186 0.559 rs2277826 chr21:47639492 C/G cg12516959 chr21:47718080 NA 0.35 6.0 0.31 5.11e-9 Testicular germ cell tumor; CRC cis rs1552244 1.000 rs9809061 chr3:10085130 C/G cg18598329 chr3:10140678 FANCD2;C3orf24 -0.89 -12.69 -0.57 2.6e-30 Alzheimer's disease; CRC cis rs2243480 1.000 rs462853 chr7:65558167 G/C cg12463550 chr7:65579703 CRCP 0.68 6.55 0.34 2.22e-10 Diabetic kidney disease; CRC cis rs10504229 0.775 rs55825382 chr8:58157605 G/A cg22535103 chr8:58192502 C8orf71 -0.7 -8.4 -0.42 1.36e-15 Developmental language disorder (linguistic errors); CRC cis rs9308731 0.583 rs2165107 chr2:111931350 C/G cg04202892 chr2:111875749 ACOXL 0.42 6.73 0.35 7.37e-11 Chronic lymphocytic leukemia; CRC cis rs11792861 0.816 rs113624314 chr9:111689953 G/A cg05043794 chr9:111880884 C9orf5 -0.33 -5.78 -0.3 1.7e-8 Menarche (age at onset); CRC cis rs6952808 0.693 rs10950413 chr7:1912988 A/G cg22963979 chr7:1858916 MAD1L1 -0.47 -7.57 -0.39 3.76e-13 Bipolar disorder and schizophrenia; CRC cis rs514406 0.929 rs557715 chr1:53321593 C/G cg08859206 chr1:53392774 SCP2 -0.42 -6.77 -0.35 6.03e-11 Monocyte count; CRC cis rs3760982 1.000 rs3760982 chr19:44286513 A/G cg21496419 chr19:44306685 LYPD5 0.34 6.47 0.34 3.65e-10 Breast cancer (estrogen-receptor negative);Breast cancer; CRC cis rs6500602 0.702 rs1051308 chr16:4560301 A/G cg08645402 chr16:4508243 NA -0.62 -11.06 -0.52 2.11e-24 Schizophrenia; CRC cis rs853679 0.517 rs9393898 chr6:28130376 G/T cg03623178 chr6:28175578 NA 0.97 12.38 0.56 3.55e-29 Depression; CRC cis rs780096 0.526 rs1647267 chr2:27651054 A/T cg12648201 chr2:27665141 KRTCAP3 -0.31 -6.18 -0.32 1.88e-9 Total body bone mineral density; CRC cis rs8063761 0.689 rs4785763 chr16:90066936 G/T cg12064134 chr16:90016061 DEF8 -0.53 -8.17 -0.41 6.73e-15 Squamous cell carcinoma; CRC cis rs1552244 0.882 rs56332224 chr3:10037321 G/A cg10729496 chr3:10149963 C3orf24 0.51 6.64 0.34 1.27e-10 Alzheimer's disease; CRC cis rs12505749 0.542 rs55915354 chr4:57370023 G/T cg06922635 chr4:57371607 ARL9 -0.54 -5.71 -0.3 2.54e-8 Airflow obstruction; CRC cis rs1799949 0.965 rs8176087 chr17:41270666 C/A cg01879757 chr17:41196368 BRCA1 -0.41 -6.14 -0.32 2.41e-9 Menopause (age at onset); CRC cis rs9434723 1.000 rs9434723 chr1:9292282 C/T cg04199779 chr1:9294473 H6PD 0.54 6.21 0.32 1.6e-9 Height; CRC cis rs1559088 0.847 rs10416218 chr19:33599127 T/C cg27124370 chr19:33622961 WDR88 0.45 6.29 0.33 1.04e-9 Bone ultrasound measurement (broadband ultrasound attenuation); CRC cis rs2067615 0.579 rs10861657 chr12:107131314 A/G cg13491945 chr12:107078410 RFX4 0.35 5.98 0.31 5.87e-9 Heart rate; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg11566939 chr17:7155231 DULLARD;C17orf81 0.43 6.24 0.33 1.36e-9 Intelligence (multi-trait analysis); CRC cis rs7618501 0.602 rs2013208 chr3:50129399 C/T cg24110177 chr3:50126178 RBM5 0.48 7.31 0.37 2e-12 Intelligence (multi-trait analysis); CRC trans rs3780486 0.505 rs1411609 chr9:33137303 C/T cg04842962 chr6:43655489 MRPS18A 0.94 16.05 0.66 3.3e-43 IgG glycosylation; CRC cis rs11971779 0.648 rs9642121 chr7:139092621 G/A cg23387468 chr7:139079360 LUC7L2 0.41 7.04 0.36 1.14e-11 Diisocyanate-induced asthma; CRC trans rs11039798 1.000 rs12225599 chr11:48755868 T/C cg03929089 chr4:120376271 NA 0.63 6.06 0.32 3.73e-9 Axial length; CRC cis rs6951245 1.000 rs76833820 chr7:1070278 A/T cg18402987 chr7:1209562 NA 0.64 6.77 0.35 6.03e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs2985684 1.000 rs2985696 chr14:50094913 C/A cg10008539 chr14:50087325 RPL36AL;MGAT2 -0.46 -6.23 -0.32 1.43e-9 Carotid intima media thickness; CRC cis rs4727027 0.933 rs917123 chr7:148848358 G/A cg23583168 chr7:148888333 NA -0.92 -15.85 -0.66 1.93e-42 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC cis rs897984 0.572 rs112906665 chr16:31040139 T/C cg00531865 chr16:30841666 NA -0.46 -6.45 -0.34 3.88e-10 Dementia with Lewy bodies; CRC cis rs6502050 0.765 rs55905076 chr17:80105441 G/A cg25804541 chr17:80189381 SLC16A3 -0.3 -5.89 -0.31 9.4e-9 Life satisfaction; CRC cis rs4689592 0.503 rs2292461 chr4:7058473 C/T cg26116260 chr4:7069785 GRPEL1 0.79 9.8 0.48 4.47e-20 Monocyte percentage of white cells; CRC cis rs853679 0.517 rs9348794 chr6:28117757 T/A cg02683197 chr6:28174875 NA 0.87 10.73 0.51 3.25e-23 Depression; CRC cis rs9303401 0.659 rs62083368 chr17:56878062 G/A cg02118635 chr17:56770003 RAD51C;TEX14 0.78 9.87 0.48 2.6e-20 Cognitive test performance; CRC cis rs7412746 0.658 rs59988025 chr1:150940358 C/T cg17724175 chr1:150552817 MCL1 0.47 7.0 0.36 1.46e-11 Melanoma; CRC cis rs12220238 0.730 rs4746177 chr10:75913033 G/A cg19889307 chr10:75911429 ADK;AP3M1 0.64 6.4 0.33 5.33e-10 Soluble interleukin-2 receptor subunit alpha; CRC cis rs7772486 0.743 rs62433835 chr6:146032688 C/G cg23711669 chr6:146136114 FBXO30 -0.65 -10.88 -0.51 9.23e-24 Lobe attachment (rater-scored or self-reported); CRC cis rs262150 0.522 rs2527182 chr7:158813812 A/G cg10570241 chr7:158785291 NA 0.38 6.45 0.33 4.1e-10 Facial morphology (factor 20); CRC cis rs10504229 0.817 rs78138632 chr8:58191341 G/T cg24829409 chr8:58192753 C8orf71 -0.74 -8.89 -0.44 3.97e-17 Developmental language disorder (linguistic errors); CRC cis rs4843747 0.671 rs74729706 chr16:88104159 C/T cg07865391 chr16:88106882 BANP 0.47 6.02 0.31 4.75e-9 Menopause (age at onset); CRC trans rs1005277 0.579 rs116912400 chr10:38479207 G/T cg23533926 chr12:111358616 MYL2 -0.54 -8.21 -0.41 5e-15 Extrinsic epigenetic age acceleration; CRC cis rs17067123 0.614 rs11723608 chr4:180077492 A/C cg26610307 chr4:180072759 NA -0.5 -5.71 -0.3 2.55e-8 Response to hepatitis C treatment; CRC cis rs8062405 0.755 rs62034355 chr16:28581038 G/C cg16576597 chr16:28551801 NUPR1 0.51 6.99 0.36 1.51e-11 Cognitive ability (multi-trait analysis);Cognitive ability; CRC cis rs9807841 0.617 rs892087 chr19:10794793 C/T cg17710535 chr19:10819994 QTRT1 0.47 7.21 0.37 3.81e-12 Inflammatory skin disease; CRC cis rs34172651 0.917 rs8043962 chr16:24781372 A/G cg06028605 chr16:24865363 SLC5A11 0.4 7.55 0.38 4.39e-13 Intelligence (multi-trait analysis); CRC cis rs9875589 0.509 rs1488377 chr3:14073178 C/G cg14375111 chr3:14165186 TMEM43;CHCHD4 0.41 5.72 0.3 2.35e-8 Ovarian reserve; CRC cis rs2204008 0.560 rs4129033 chr12:38301897 A/T cg13010199 chr12:38710504 ALG10B -0.4 -5.74 -0.3 2.16e-8 Bladder cancer; CRC cis rs7833986 0.501 rs72653953 chr8:56970795 C/T cg23139584 chr8:56987506 RPS20;SNORD54 0.88 12.1 0.55 3.97e-28 Height; CRC cis rs6763159 0.566 rs12493090 chr3:59641065 A/C cg07069742 chr3:59644285 NA -0.44 -8.82 -0.44 6.62e-17 Conotruncal heart defects; CRC trans rs2980439 0.525 rs2980508 chr8:8171732 C/T cg16141378 chr3:129829833 LOC729375 -0.41 -6.22 -0.32 1.52e-9 Neuroticism; CRC trans rs5756813 0.661 rs2285178 chr22:38205989 T/C cg19894588 chr14:64061835 NA -0.62 -8.41 -0.42 1.3e-15 Optic cup area;Vertical cup-disc ratio; CRC cis rs7917772 0.565 rs61869210 chr10:104437175 A/C cg22532475 chr10:104410764 TRIM8 -0.42 -6.92 -0.36 2.37e-11 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC cis rs4654899 0.785 rs7531381 chr1:21403348 A/G cg02927042 chr1:21476669 EIF4G3 -0.38 -6.01 -0.31 4.81e-9 Superior frontal gyrus grey matter volume; CRC cis rs10504229 0.683 rs11786843 chr8:58133629 T/C cg22535103 chr8:58192502 C8orf71 -0.69 -9.14 -0.45 6.55e-18 Developmental language disorder (linguistic errors); CRC cis rs875971 0.505 rs1167385 chr7:65513308 G/A cg11764359 chr7:65958608 NA -0.53 -8.07 -0.41 1.29e-14 Aortic root size; CRC cis rs7927771 1.000 rs4752873 chr11:47857520 C/T cg18512352 chr11:47633146 NA -0.48 -9.36 -0.46 1.27e-18 Subjective well-being; CRC cis rs7474896 0.559 rs1779075 chr10:38167530 C/G cg25427524 chr10:38739819 LOC399744 0.66 8.11 0.41 1.03e-14 Obesity (extreme); CRC cis rs7312933 0.618 rs6582394 chr12:42686189 A/G cg11827402 chr12:42719852 PPHLN1;ZCRB1 0.62 8.79 0.44 8.39e-17 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CRC cis rs35306767 0.903 rs34270014 chr10:904666 T/C cg20503657 chr10:835505 NA 0.85 10.82 0.51 1.51e-23 Eosinophil percentage of granulocytes; CRC cis rs9457247 0.765 rs9459836 chr6:167419105 G/A cg23791538 chr6:167370224 RNASET2 -0.39 -5.89 -0.31 9.73e-9 Crohn's disease; CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg23300289 chr9:132146083 NA -0.51 -6.34 -0.33 7.57e-10 Diisocyanate-induced asthma; CRC cis rs561341 1.000 rs55736640 chr17:30333848 G/A cg12193833 chr17:30244370 NA -0.76 -8.89 -0.44 4.24e-17 Hip circumference adjusted for BMI; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg10728060 chr13:53029403 CKAP2 0.48 6.99 0.36 1.57e-11 Response to antipsychotic treatment; CRC cis rs9381040 0.655 rs7775972 chr6:41038116 A/C cg04346459 chr6:41068666 NFYA;LOC221442 -0.4 -5.85 -0.31 1.2e-8 Alzheimer's disease (late onset); CRC cis rs9311474 0.841 rs352139 chr3:52258372 T/C cg08222913 chr3:52553049 STAB1 -0.35 -6.61 -0.34 1.53e-10 Electroencephalogram traits; CRC cis rs2404602 0.698 rs12909656 chr15:76664378 A/T cg23625390 chr15:77176239 SCAPER -0.83 -13.42 -0.59 4.88e-33 Blood metabolite levels; CRC cis rs7772486 0.790 rs10223507 chr6:146285204 C/A cg13319975 chr6:146136371 FBXO30 0.4 5.87 0.31 1.05e-8 Lobe attachment (rater-scored or self-reported); CRC cis rs1552244 0.832 rs67145301 chr3:10197314 G/A cg13047869 chr3:10149882 C3orf24 0.58 6.91 0.36 2.56e-11 Alzheimer's disease; CRC cis rs7212590 0.618 rs56142307 chr17:57878149 A/G cg10252138 chr17:58120427 NA -0.54 -5.67 -0.3 3.07e-8 Granulocyte percentage of myeloid white cells;Monocyte count;Monocyte percentage of white cells; CRC cis rs13191362 1.000 rs35593345 chr6:163174981 G/C cg23758597 chr6:163146217 PARK2 -0.72 -7.28 -0.37 2.49e-12 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs9814567 0.964 rs9815983 chr3:134222507 G/T cg06541857 chr3:134203789 ANAPC13;CEP63 -0.41 -6.22 -0.32 1.48e-9 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs9303401 0.659 rs12946852 chr17:57013337 G/C cg10487724 chr17:56770010 TEX14;RAD51C 0.78 9.76 0.47 6.05e-20 Cognitive test performance; CRC cis rs3772130 0.962 rs13061326 chr3:121493125 T/C cg20356878 chr3:121714668 ILDR1 0.51 8.05 0.41 1.53e-14 Cognitive performance; CRC cis rs1059312 1.000 rs7135854 chr12:129279988 G/C cg21616243 chr12:129299702 MGC16384;SLC15A4 -0.66 -10.8 -0.51 1.76e-23 Systemic lupus erythematosus; CRC trans rs11885103 0.519 rs2685263 chr2:549873 C/G cg12228919 chr15:44955936 SPG11 0.45 6.97 0.36 1.74e-11 Heschl's gyrus morphology; CRC cis rs10751667 0.666 rs10902248 chr11:957742 A/G cg06064525 chr11:970664 AP2A2 -0.3 -6.22 -0.32 1.49e-9 Alzheimer's disease (late onset); CRC cis rs6860806 0.661 rs3763112 chr5:131586480 A/G cg22638593 chr5:131593259 PDLIM4 0.41 7.54 0.38 4.58e-13 Breast cancer; CRC cis rs7254114 0.578 rs7246614 chr19:11310538 C/T cg02815516 chr19:11306319 KANK2 -0.35 -6.46 -0.34 3.87e-10 Immature fraction of reticulocytes; CRC cis rs601339 1.000 rs507525 chr12:123181581 T/C cg25190513 chr12:123201362 GPR109B -0.48 -5.9 -0.31 9.24e-9 Adiponectin levels; CRC cis rs3015497 0.594 rs35637875 chr14:51132533 T/G cg09863266 chr14:51125203 SAV1 -0.31 -5.85 -0.31 1.2e-8 Mean platelet volume; CRC cis rs7618501 0.633 rs3774733 chr3:50037123 C/G cg24308560 chr3:49941425 MST1R -0.51 -8.22 -0.41 4.87e-15 Intelligence (multi-trait analysis); CRC cis rs1552244 0.572 rs67227131 chr3:10172744 G/A cg13047869 chr3:10149882 C3orf24 0.55 6.01 0.31 4.98e-9 Alzheimer's disease; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg01375172 chr16:23464338 COG7 0.44 6.09 0.32 3.11e-9 Response to antipsychotic treatment; CRC cis rs7224685 0.501 rs11652060 chr17:4010412 A/T cg09597638 chr17:3907349 NA -0.68 -11.92 -0.55 1.86e-27 Type 2 diabetes; CRC trans rs7615952 0.932 rs1976458 chr3:125647512 T/G cg07211511 chr3:129823064 LOC729375 -1.07 -17.86 -0.7 2.45e-50 Blood pressure (smoking interaction); CRC cis rs4819052 0.851 rs28676615 chr21:46676576 G/C cg11663144 chr21:46675770 NA -0.83 -14.06 -0.61 1.78e-35 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs12760731 0.720 rs12022646 chr1:178355821 A/G cg00404053 chr1:178313656 RASAL2 0.94 9.65 0.47 1.46e-19 Obesity-related traits; CRC cis rs2075165 0.901 rs2274226 chr1:156314627 C/T cg20302342 chr1:156215951 PAQR6 -0.37 -7.22 -0.37 3.58e-12 Tonsillectomy; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg03199721 chr4:75023540 MTHFD2L 0.49 6.84 0.35 3.82e-11 Response to antipsychotic treatment; CRC cis rs1218582 0.772 rs6669791 chr1:154845484 G/T cg06221963 chr1:154839813 KCNN3 -0.82 -17.5 -0.69 6.01e-49 Prostate cancer; CRC cis rs1862618 0.853 rs6885541 chr5:56110857 G/C cg24531977 chr5:56204891 C5orf35 -0.84 -11.16 -0.52 9.37e-25 Initial pursuit acceleration; CRC cis rs7224685 0.608 rs17763551 chr17:3882309 C/T cg05562828 chr17:3906858 NA 0.47 6.03 0.32 4.36e-9 Type 2 diabetes; CRC cis rs4689388 0.853 rs1079216 chr4:6282473 T/C cg14416269 chr4:6271139 WFS1 0.38 6.13 0.32 2.51e-9 Type 2 diabetes and other traits;Type 2 diabetes; CRC cis rs62064224 0.606 rs61390192 chr17:30837447 C/T cg24550644 chr17:30846204 MYO1D -0.4 -6.68 -0.35 1.01e-10 Schizophrenia; CRC cis rs3018066 0.640 rs28787305 chr4:107034947 C/A cg01869342 chr4:106983673 TBCK 0.46 6.03 0.32 4.52e-9 Cancer; CRC cis rs7617480 0.648 rs9848268 chr3:48762271 C/T cg07636037 chr3:49044803 WDR6 0.85 9.79 0.48 4.94e-20 Subjective well-being (multi-trait analysis);Menarche (age at onset); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg16313264 chr11:57103491 SSRP1 0.43 6.14 0.32 2.32e-9 Response to antipsychotic treatment; CRC cis rs2976388 0.578 rs3758081 chr8:143824373 A/G cg12516270 chr8:143859308 LYNX1 -0.42 -6.55 -0.34 2.18e-10 Urinary tract infection frequency; CRC cis rs853679 0.517 rs4713135 chr6:28039586 G/A cg12273811 chr6:28175739 NA 0.69 8.81 0.44 7.29e-17 Depression; CRC cis rs2404602 0.692 rs2304920 chr15:76993867 T/C cg23625390 chr15:77176239 SCAPER 0.49 7.26 0.37 2.76e-12 Blood metabolite levels; CRC cis rs6089584 0.606 rs2144674 chr20:60576579 G/A cg13770153 chr20:60521292 NA -0.45 -7.33 -0.37 1.84e-12 Body mass index; CRC cis rs10504229 0.683 rs2088217 chr8:58113124 C/T cg22535103 chr8:58192502 C8orf71 -0.7 -9.2 -0.45 4.33e-18 Developmental language disorder (linguistic errors); CRC cis rs17270561 0.666 rs1937129 chr6:25789132 A/G cg17691542 chr6:26056736 HIST1H1C 0.61 7.96 0.4 2.85e-14 Iron status biomarkers; CRC cis rs35110281 0.720 rs162392 chr21:44941406 A/G cg01579765 chr21:45077557 HSF2BP -0.37 -7.05 -0.36 1.06e-11 Mean corpuscular volume; CRC cis rs870825 0.587 rs28454955 chr4:185632701 C/T cg04058563 chr4:185651563 MLF1IP 0.73 9.38 0.46 1.13e-18 Blood protein levels; CRC cis rs9303401 0.614 rs34920953 chr17:56589406 G/A cg10487724 chr17:56770010 TEX14;RAD51C 0.79 9.6 0.47 2.14e-19 Cognitive test performance; CRC cis rs3099143 0.901 rs76101229 chr15:77134975 C/T cg21673338 chr15:77095150 SCAPER -0.78 -6.5 -0.34 3.05e-10 Recalcitrant atopic dermatitis; CRC cis rs6502050 0.723 rs11650633 chr17:80083807 T/C cg13198984 chr17:80129470 CCDC57 -0.48 -8.55 -0.43 4.72e-16 Life satisfaction; CRC cis rs2303759 0.709 rs10414921 chr19:49823047 C/T cg24324837 chr19:49891574 CCDC155 0.53 7.0 0.36 1.45e-11 Multiple sclerosis; CRC cis rs10911251 0.527 rs1537520 chr1:183084229 C/T ch.1.3577855R chr1:183094577 LAMC1 0.88 15.17 0.64 8.69e-40 Colorectal cancer; CRC cis rs9291683 0.554 rs7668175 chr4:10125782 T/C cg00071950 chr4:10020882 SLC2A9 -0.48 -8.12 -0.41 9.38e-15 Bone mineral density; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg06995624 chr17:73043174 ATP5H;KCTD2 0.43 6.41 0.33 5.14e-10 Intelligence (multi-trait analysis); CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg19828298 chr1:3713105 LRRC47 -0.6 -7.55 -0.38 4.28e-13 Diisocyanate-induced asthma; CRC cis rs72730918 0.564 rs1902595 chr15:51905715 T/C cg14296394 chr15:51910925 DMXL2 -0.45 -5.87 -0.31 1.04e-8 Intelligence (multi-trait analysis); CRC cis rs853679 0.760 rs2299029 chr6:28198831 G/A cg15786705 chr6:28176104 NA 0.64 7.1 0.36 7.64e-12 Depression; CRC cis rs4713118 0.824 rs13211701 chr6:27750079 T/C cg12273811 chr6:28175739 NA 0.5 6.63 0.34 1.38e-10 Parkinson's disease; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg16618282 chr3:47018402 CCDC12 -0.46 -6.96 -0.36 1.9e-11 Liver disease severity in Alagille syndrome; CRC cis rs7811142 1.000 rs11559117 chr7:100076614 A/G cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.92 12.27 0.56 9.74e-29 Platelet count; CRC cis rs9287719 0.601 rs12692412 chr2:10720054 A/G cg00105475 chr2:10696890 NA -0.47 -7.16 -0.37 5.43e-12 Prostate cancer; CRC cis rs1707322 0.721 rs11211151 chr1:46112752 T/C cg03146154 chr1:46216737 IPP 0.67 9.72 0.47 8.8e-20 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs6938 0.534 rs1130741 chr15:75189930 A/G cg17294928 chr15:75287854 SCAMP5 0.52 8.06 0.41 1.43e-14 Breast cancer; CRC cis rs3864277 0.510 rs31478 chr5:131423475 T/C cg18758796 chr5:131593413 PDLIM4 0.36 6.32 0.33 8.63e-10 Itch intensity from mosquito bite adjusted by bite size; CRC cis rs877282 0.898 rs12356744 chr10:757477 G/C cg17470449 chr10:769945 NA 0.64 8.39 0.42 1.42e-15 Uric acid levels; CRC cis rs7937682 0.924 rs875257 chr11:111530453 A/G cg09085632 chr11:111637200 PPP2R1B -1.0 -20.15 -0.74 2.29e-59 Primary sclerosing cholangitis; CRC cis rs172166 0.694 rs203877 chr6:28048624 T/C cg20615401 chr6:28092323 ZSCAN16 0.46 6.09 0.32 3.24e-9 Cardiac Troponin-T levels; CRC trans rs1941687 0.505 rs8091920 chr18:31303557 C/G cg27147174 chr7:100797783 AP1S1 -0.39 -6.7 -0.35 9.06e-11 Subjective well-being (multi-trait analysis);Subjective well-being; CRC cis rs826838 1.000 rs11183941 chr12:38851692 G/C cg13010199 chr12:38710504 ALG10B 0.46 6.04 0.32 4.14e-9 Heart rate; CRC trans rs9467711 0.606 rs34781270 chr6:26593037 A/G cg06606381 chr12:133084897 FBRSL1 -1.07 -7.41 -0.38 1.09e-12 Autism spectrum disorder or schizophrenia; CRC trans rs7267979 0.816 rs443009 chr20:25499817 A/G cg17903999 chr18:56338584 MALT1 0.37 6.13 0.32 2.45e-9 Liver enzyme levels (alkaline phosphatase); CRC cis rs7089973 0.624 rs10885614 chr10:116609098 C/T cg23260525 chr10:116636907 FAM160B1 0.35 8.11 0.41 1.04e-14 Bipolar disorder or attention deficit hyperactivity disorder; CRC cis rs11628318 0.588 rs12892602 chr14:103114091 T/C cg12046867 chr14:103022105 NA 0.42 6.1 0.32 2.94e-9 Platelet count; CRC cis rs9399135 0.935 rs11759999 chr6:135370495 G/T cg22676075 chr6:135203613 NA 0.39 6.08 0.32 3.36e-9 Red blood cell count; CRC cis rs1799949 1.000 rs3092988 chr17:41201702 C/T cg19454999 chr17:41278357 BRCA1;NBR2 0.52 8.14 0.41 8.01e-15 Menopause (age at onset); CRC trans rs2303319 0.504 rs1006427 chr2:162592328 T/C cg22922770 chr7:98923339 ARPC1A -0.67 -5.98 -0.31 5.68e-9 Cognitive function; CRC cis rs7772486 0.754 rs9390358 chr6:146145678 C/T cg05347473 chr6:146136440 FBXO30 0.4 6.03 0.32 4.5e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs4713118 0.696 rs2394002 chr6:27748015 G/A cg20933634 chr6:27740509 NA 0.65 9.14 0.45 6.66e-18 Parkinson's disease; CRC cis rs422249 0.504 rs174538 chr11:61560081 G/A cg06781209 chr11:61594997 FADS2 -0.39 -5.66 -0.3 3.27e-8 Trans fatty acid levels; CRC cis rs10208940 0.920 rs34366735 chr2:68771995 A/G cg12452813 chr2:68675892 NA 0.46 5.77 0.3 1.79e-8 Urate levels in lean individuals; CRC cis rs5750830 0.594 rs5757650 chr22:39778419 A/G cg11247378 chr22:39784982 NA -0.5 -9.27 -0.46 2.53e-18 Intelligence (multi-trait analysis); CRC cis rs6121246 0.559 rs6060922 chr20:30333909 C/T cg13852791 chr20:30311386 BCL2L1 0.77 15.72 0.66 6.04e-42 Mean corpuscular hemoglobin; CRC cis rs10779751 0.734 rs1034528 chr1:11249132 G/C cg08854313 chr1:11322531 MTOR -0.66 -9.26 -0.45 2.66e-18 Body mass index; CRC cis rs12995491 0.731 rs34991383 chr2:88500337 T/G cg14558114 chr2:88469736 THNSL2 -0.47 -6.79 -0.35 5.36e-11 Response to metformin (IC50); CRC cis rs12497850 0.931 rs13064911 chr3:48952385 A/G cg07636037 chr3:49044803 WDR6 1.02 17.91 0.7 1.45e-50 Parkinson's disease; CRC cis rs514406 0.929 rs1672908 chr1:53340885 A/G cg25767906 chr1:53392781 SCP2 -0.45 -7.13 -0.37 6.28e-12 Monocyte count; CRC cis rs73206853 0.841 rs57216167 chr12:110940748 C/T cg12870014 chr12:110450643 ANKRD13A 0.82 8.53 0.43 5.39e-16 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg02294249 chr13:34392492 RFC3 0.53 6.76 0.35 6.25e-11 Thyroid stimulating hormone; CRC cis rs7927771 1.000 rs12418852 chr11:47868853 C/G cg18512352 chr11:47633146 NA -0.48 -9.36 -0.46 1.29e-18 Subjective well-being; CRC cis rs7666738 0.753 rs13111199 chr4:98953705 A/G cg17366294 chr4:99064904 C4orf37 0.43 7.34 0.38 1.69e-12 Colonoscopy-negative controls vs population controls; CRC cis rs832540 0.866 rs252894 chr5:56224339 A/C cg12311346 chr5:56204834 C5orf35 0.45 6.5 0.34 2.9e-10 Coronary artery disease; CRC cis rs2179367 0.959 rs9377212 chr6:149704901 G/C cg11245181 chr6:149772854 ZC3H12D -0.41 -6.5 -0.34 2.9e-10 Dupuytren's disease; CRC cis rs713587 0.935 rs11676272 chr2:25141538 A/G cg22495460 chr2:25135724 ADCY3 -0.8 -14.63 -0.63 1.09e-37 Body mass index in non-asthmatics; CRC cis rs734999 0.588 rs10910099 chr1:2533552 G/T cg20673091 chr1:2541236 MMEL1 -0.35 -5.61 -0.3 4.24e-8 Ulcerative colitis; CRC cis rs2439831 0.850 rs8042868 chr15:43939642 C/T cg02155558 chr15:43621948 ADAL;LCMT2 0.79 8.13 0.41 9.08e-15 Lung cancer in ever smokers; CRC cis rs875971 0.502 rs1796227 chr7:66087019 G/C cg11764359 chr7:65958608 NA -0.46 -5.72 -0.3 2.37e-8 Aortic root size; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg22744680 chr16:3014898 KREMEN2 0.49 6.8 0.35 5e-11 Response to antipsychotic treatment; CRC cis rs6674176 0.660 rs6801 chr1:44396646 C/G cg15962314 chr1:44399869 ARTN -0.3 -5.84 -0.31 1.23e-8 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Cognitive ability; CRC cis rs2032447 0.507 rs199741 chr6:25931577 A/G cg04800585 chr6:26043546 HIST1H2BB 0.46 5.97 0.31 5.99e-9 Intelligence (multi-trait analysis); CRC cis rs11628318 0.803 rs10138267 chr14:103035432 C/T cg23071808 chr14:103021642 NA -0.68 -8.91 -0.44 3.44e-17 Platelet count; CRC cis rs12024301 0.557 rs10911414 chr1:183663149 T/C cg11505048 chr1:183622726 RGL1;APOBEC4 0.7 6.23 0.32 1.46e-9 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs3087591 0.683 rs757375 chr17:29717879 C/G cg24425628 chr17:29625626 OMG;NF1 0.68 12.44 0.57 2.18e-29 Hip circumference; CRC trans rs916888 0.773 rs199447 chr17:44812188 C/T cg01341218 chr17:43662625 NA 0.97 10.57 0.5 1.1e-22 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs832540 0.656 rs6893754 chr5:56100006 G/A cg24531977 chr5:56204891 C5orf35 -0.5 -7.56 -0.38 4.12e-13 Coronary artery disease; CRC cis rs875971 0.651 rs313829 chr7:65552497 A/G cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.55 -7.42 -0.38 9.95e-13 Aortic root size; CRC cis rs7917772 0.503 rs7096072 chr10:104299976 C/T cg22532475 chr10:104410764 TRIM8 -0.36 -6.62 -0.34 1.43e-10 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg01402409 chr4:78978133 FRAS1 0.4 6.19 0.32 1.8e-9 Liver disease severity in Alagille syndrome; CRC cis rs9309473 0.948 rs10170849 chr2:73747932 G/A cg20560298 chr2:73613845 ALMS1 -0.47 -5.61 -0.3 4.31e-8 Metabolite levels; CRC cis rs7119 0.717 rs8032405 chr15:77825344 A/G cg27398640 chr15:77910606 LINGO1 -0.42 -7.26 -0.37 2.87e-12 Type 2 diabetes; CRC cis rs4563143 0.675 rs34113156 chr19:29270822 G/A cg12667521 chr19:29218732 NA 0.5 7.55 0.38 4.25e-13 Methadone dose in opioid dependence; CRC cis rs853679 0.517 rs1904840 chr6:28108232 C/T cg02631126 chr6:28058918 ZSCAN12L1 0.29 5.91 0.31 8.38e-9 Depression; CRC cis rs1008375 1.000 rs7694020 chr4:17682597 C/T cg15017067 chr4:17643749 FAM184B 0.36 5.73 0.3 2.22e-8 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs7312933 0.533 rs17551006 chr12:42848738 G/C cg11827402 chr12:42719852 PPHLN1;ZCRB1 0.65 9.34 0.46 1.49e-18 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CRC cis rs9487051 1.000 rs1546723 chr6:109625879 G/A cg21918786 chr6:109611834 NA -0.38 -6.49 -0.34 3.25e-10 Reticulocyte fraction of red cells; CRC cis rs6912958 0.781 rs6940150 chr6:88287114 T/C cg12350822 chr6:88032061 C6orf162;GJB7 -0.34 -6.37 -0.33 6.44e-10 Monocyte percentage of white cells; CRC cis rs9326248 1.000 rs664971 chr11:117070857 A/G cg10398005 chr11:117014888 PAFAH1B2 0.4 5.64 0.3 3.6e-8 Blood protein levels; CRC cis rs1059312 1.000 rs2291350 chr12:129283711 G/A cg04043695 chr12:129287642 SLC15A4 0.38 5.74 0.3 2.11e-8 Systemic lupus erythematosus; CRC cis rs919433 0.680 rs11680291 chr2:198409884 A/G cg10820045 chr2:198174542 NA 0.41 6.94 0.36 2.09e-11 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC cis rs11958404 0.932 rs112993559 chr5:157414712 A/C cg05962755 chr5:157440814 NA 0.85 11.44 0.53 9.59e-26 IgG glycosylation; CRC trans rs6703335 0.870 rs10803142 chr1:243598234 A/G cg15309264 chr2:58274034 VRK2 0.42 6.17 0.32 2.03e-9 Schizophrenia;Schizophrenia, schizoaffective disorder or bipolar disorder; CRC cis rs9420 0.961 rs576859 chr11:57480623 A/C cg23127183 chr11:57508653 C11orf31 0.53 7.39 0.38 1.22e-12 Schizophrenia; CRC cis rs708547 0.874 rs1718868 chr4:57881215 G/T cg25525207 chr4:57843836 C4orf14;POLR2B -0.46 -5.7 -0.3 2.73e-8 Response to bleomycin (chromatid breaks); CRC cis rs6952808 0.929 rs34145223 chr7:1926237 G/A cg14004847 chr7:1930337 MAD1L1 -0.43 -5.79 -0.3 1.62e-8 Bipolar disorder and schizophrenia; CRC cis rs597539 0.652 rs513615 chr11:68705504 G/T cg06028808 chr11:68637592 NA 0.36 5.66 0.3 3.33e-8 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs2976388 0.565 rs2572905 chr8:143797104 C/T cg20041105 chr8:143859282 LYNX1 0.43 7.8 0.4 8.17e-14 Urinary tract infection frequency; CRC cis rs6500395 0.735 rs74017013 chr16:48664120 G/A cg04672837 chr16:48644449 N4BP1 0.44 6.53 0.34 2.53e-10 Response to tocilizumab in rheumatoid arthritis; CRC cis rs12497850 1.000 rs10865952 chr3:48744484 A/G cg07636037 chr3:49044803 WDR6 0.93 15.89 0.66 1.37e-42 Parkinson's disease; CRC cis rs34779708 0.897 rs16935880 chr10:35415468 C/G cg03585969 chr10:35415529 CREM 0.65 8.64 0.43 2.56e-16 Inflammatory bowel disease;Crohn's disease; CRC cis rs34779708 0.966 rs11010129 chr10:35510822 T/C cg03585969 chr10:35415529 CREM 0.56 7.48 0.38 6.89e-13 Inflammatory bowel disease;Crohn's disease; CRC cis rs8060686 0.920 rs111315946 chr16:67889793 G/C cg08314208 chr16:67682810 RLTPR -0.61 -7.0 -0.36 1.48e-11 HDL cholesterol;Metabolic syndrome; CRC cis rs4076764 0.914 rs10753614 chr1:163365903 C/T cg24596788 chr1:163392923 NA 0.64 10.4 0.5 4.47e-22 Motion sickness; CRC cis rs912330 0.825 rs7317938 chr13:99234361 C/T cg07423050 chr13:99094983 FARP1 -0.4 -5.83 -0.31 1.35e-8 Alzheimer's disease; CRC cis rs1050631 0.592 rs9958282 chr18:33710440 T/A cg25426722 chr18:33708991 SLC39A6;ELP2 -0.38 -5.92 -0.31 8.25e-9 Esophageal squamous cell cancer (length of survival); CRC cis rs6952808 0.929 rs11768206 chr7:1932151 T/G cg14004847 chr7:1930337 MAD1L1 -0.42 -5.68 -0.3 3.04e-8 Bipolar disorder and schizophrenia; CRC cis rs4975616 0.836 rs13178866 chr5:1323212 C/T cg06550200 chr5:1325588 CLPTM1L -0.75 -12.16 -0.56 2.34e-28 Lung cancer; CRC cis rs10540 1.000 rs61877775 chr11:521462 C/T cg21784768 chr11:537496 LRRC56 -0.69 -6.14 -0.32 2.41e-9 Body mass index; CRC cis rs7618915 0.501 rs34157897 chr3:52716937 T/C cg10802521 chr3:52805072 NEK4 -0.58 -9.08 -0.45 1.05e-17 Bipolar disorder; CRC cis rs2303759 0.709 rs3760667 chr19:49814832 C/T cg22307029 chr19:49891270 CCDC155 0.68 8.94 0.44 2.95e-17 Multiple sclerosis; CRC cis rs875971 0.660 rs10281080 chr7:66042441 T/C cg25985355 chr7:65971099 NA 0.32 5.71 0.3 2.54e-8 Aortic root size; CRC cis rs2046867 0.862 rs6778168 chr3:72840206 T/A cg25664220 chr3:72788482 NA -0.38 -5.85 -0.31 1.16e-8 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; CRC cis rs6693567 0.565 rs1313569 chr1:150344171 G/A cg15654264 chr1:150340011 RPRD2 0.43 6.41 0.33 5.06e-10 Migraine; CRC cis rs1336900 0.641 rs6587756 chr1:150546865 A/T cg15448220 chr1:150897856 SETDB1 -0.44 -6.16 -0.32 2.14e-9 Blood protein levels; CRC cis rs10876993 0.890 rs774888 chr12:58036506 A/G cg15848620 chr12:58087721 OS9 -0.6 -8.15 -0.41 7.76e-15 Celiac disease or Rheumatoid arthritis; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg04903157 chr22:35795952 MCM5 0.44 6.5 0.34 3e-10 Intelligence (multi-trait analysis); CRC cis rs1799949 1.000 rs4793190 chr17:41200109 T/C cg01879757 chr17:41196368 BRCA1 -0.41 -6.26 -0.33 1.24e-9 Menopause (age at onset); CRC cis rs4319547 0.585 rs7952868 chr12:122846949 A/G cg23029597 chr12:123009494 RSRC2 -0.53 -6.26 -0.33 1.21e-9 Body mass index; CRC cis rs6968419 0.692 rs10500060 chr7:115900686 C/T cg02561103 chr7:115862891 TES -0.44 -6.53 -0.34 2.51e-10 Intraocular pressure; CRC cis rs2050392 0.517 rs619864 chr10:30750950 A/G cg25182066 chr10:30743637 MAP3K8 0.57 8.1 0.41 1.1e-14 Inflammatory bowel disease; CRC cis rs921968 0.509 rs72963905 chr2:219547027 T/G cg02176678 chr2:219576539 TTLL4 -0.61 -9.59 -0.47 2.25e-19 Mean corpuscular hemoglobin concentration; CRC cis rs9486719 1.000 rs11153018 chr6:96956137 G/A cg18709589 chr6:96969512 KIAA0776 -0.51 -5.69 -0.3 2.79e-8 Migraine;Coronary artery disease; CRC cis rs7659604 1.000 rs7689714 chr4:122665943 T/A cg06713675 chr4:122721982 EXOSC9 -0.4 -6.56 -0.34 2.05e-10 Type 2 diabetes; CRC cis rs9925964 0.967 rs9936329 chr16:31140799 G/T cg10396673 chr16:31104726 VKORC1 0.34 5.64 0.3 3.76e-8 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs853679 1.000 rs1679709 chr6:28228342 A/G cg15786705 chr6:28176104 NA -0.56 -5.82 -0.31 1.43e-8 Depression; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg07344955 chr3:50374863 RASSF1 0.47 6.41 0.33 5.04e-10 Anxiety disorder; CRC cis rs17711722 0.640 rs13237956 chr7:65318029 G/A cg02869306 chr7:64672164 INTS4L1 -0.34 -5.77 -0.3 1.83e-8 Calcium levels; CRC cis rs9467711 0.591 rs13206501 chr6:26110148 T/C cg19084075 chr6:26124329 HIST1H2AC;HIST1H2BC 0.61 5.81 0.31 1.48e-8 Autism spectrum disorder or schizophrenia; CRC cis rs826838 0.967 rs826876 chr12:39123843 T/C cg26384229 chr12:38710491 ALG10B -0.62 -9.34 -0.46 1.5e-18 Heart rate; CRC cis rs651907 0.535 rs36060163 chr3:101360963 C/T cg11279151 chr3:101281821 RG9MTD1 -0.57 -7.74 -0.39 1.19e-13 Colorectal cancer; CRC cis rs1997103 1.000 rs4590393 chr7:55408990 C/T cg17469321 chr7:55412551 NA 0.72 11.28 0.53 3.48e-25 QRS interval (sulfonylurea treatment interaction); CRC cis rs780096 0.527 rs59644396 chr2:27646083 A/G cg12000995 chr2:27665139 KRTCAP3 -0.33 -6.92 -0.36 2.3e-11 Total body bone mineral density; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg11088931 chr19:6460274 SLC25A23 0.45 6.65 0.34 1.23e-10 Intelligence (multi-trait analysis); CRC cis rs829661 0.947 rs829665 chr2:30724701 T/A cg17749961 chr2:30669863 LCLAT1 1.11 10.26 0.49 1.31e-21 Midgestational circulating levels of PBDEs (fetal genetic effect); CRC cis rs11212617 0.967 rs599164 chr11:108120439 G/A cg01991180 chr11:108092276 ATM;NPAT 0.41 5.85 0.31 1.17e-8 Response to metformin in type 2 diabetes (glycemic); CRC cis rs6804368 0.649 rs9835412 chr3:30764596 T/A cg06106510 chr3:30762233 NA 0.41 7.29 0.37 2.29e-12 Blood metabolite levels; CRC cis rs2228479 0.850 rs11648689 chr16:89806732 G/A cg06656553 chr16:89960601 TCF25 -0.68 -5.71 -0.3 2.55e-8 Skin colour saturation; CRC trans rs7618501 1.000 rs3811696 chr3:49761605 C/T cg21659725 chr3:3221576 CRBN -0.91 -17.84 -0.7 2.75e-50 Intelligence (multi-trait analysis); CRC trans rs1404872 0.717 rs73049438 chr7:3329418 G/A cg25123566 chr12:47610734 FAM113B;LOC100233209 -0.52 -6.0 -0.31 5.16e-9 Facial morphology (factor 5, width of mouth relative to central midface); CRC cis rs684232 0.602 rs445268 chr17:563338 G/A cg15660573 chr17:549704 VPS53 -0.87 -15.83 -0.66 2.25e-42 Prostate cancer; CRC cis rs2404602 0.735 rs12903874 chr15:76693318 A/T cg23625390 chr15:77176239 SCAPER -0.83 -13.1 -0.59 7.97e-32 Blood metabolite levels; CRC cis rs9322193 0.923 rs10782317 chr6:150075047 C/T cg05861140 chr6:150128134 PCMT1 0.39 6.29 0.33 9.85e-10 Lung cancer; CRC cis rs7843479 0.601 rs4872209 chr8:21848832 A/T cg17168535 chr8:21777572 XPO7 0.59 10.18 0.49 2.36e-21 Mean corpuscular volume; CRC cis rs62229266 0.804 rs2835263 chr21:37430245 A/G cg12218747 chr21:37451666 NA 0.44 7.54 0.38 4.56e-13 Mitral valve prolapse; CRC cis rs2976388 1.000 rs2920295 chr8:143764937 A/G cg12516270 chr8:143859308 LYNX1 -0.33 -5.66 -0.3 3.36e-8 Urinary tract infection frequency; CRC cis rs294883 0.686 rs9456391 chr6:159732998 G/A cg14500486 chr6:159655392 FNDC1 -0.35 -6.04 -0.32 4.11e-9 Coronary artery disease; CRC cis rs9911578 0.935 rs420878 chr17:56709077 A/G cg05425664 chr17:57184151 TRIM37 -0.51 -7.97 -0.4 2.58e-14 Intelligence (multi-trait analysis); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg00573140 chr1:121141934 NA 0.46 7.15 0.37 5.62e-12 Liver disease severity in Alagille syndrome; CRC cis rs9527 0.590 rs12775302 chr10:104911356 A/G cg04362960 chr10:104952993 NT5C2 0.6 8.32 0.42 2.32e-15 Arsenic metabolism; CRC cis rs1552244 0.882 rs13075842 chr3:10055813 A/C cg18598329 chr3:10140678 FANCD2;C3orf24 -0.83 -10.71 -0.51 3.76e-23 Alzheimer's disease; CRC cis rs11971779 0.680 rs4732376 chr7:139098024 G/A cg23387468 chr7:139079360 LUC7L2 0.41 7.05 0.36 1.04e-11 Diisocyanate-induced asthma; CRC cis rs2197308 0.667 rs61920838 chr12:37856814 T/C cg13010199 chr12:38710504 ALG10B -0.49 -7.2 -0.37 4.21e-12 Morning vs. evening chronotype; CRC cis rs3008870 1.000 rs3008855 chr1:67386204 A/G cg08660285 chr1:67390436 MIER1;WDR78 -1.0 -14.4 -0.62 8.86e-37 Lymphocyte percentage of white cells; CRC cis rs7584330 0.554 rs75559690 chr2:238428454 T/C cg14458575 chr2:238380390 NA 0.69 9.02 0.45 1.59e-17 Prostate cancer; CRC cis rs9611519 0.754 rs4820435 chr22:41652846 G/T cg03806693 chr22:41940476 POLR3H -0.69 -9.22 -0.45 3.55e-18 Neuroticism; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg10377451 chr4:140375014 RAB33B 0.44 6.1 0.32 3.04e-9 Response to antipsychotic treatment; CRC cis rs995000 0.931 rs10889350 chr1:63085266 C/T cg19896129 chr1:63156450 NA 0.42 6.53 0.34 2.48e-10 Triglyceride levels; CRC cis rs6582630 0.555 rs11181657 chr12:38381858 T/C cg26384229 chr12:38710491 ALG10B -0.65 -9.43 -0.46 7.85e-19 Drug-induced liver injury (flucloxacillin); CRC cis rs6460942 0.908 rs75704904 chr7:12233583 G/A cg06484146 chr7:12443880 VWDE -0.58 -6.08 -0.32 3.36e-9 Coronary artery disease; CRC cis rs6973256 0.583 rs6955530 chr7:133339511 T/C cg10665199 chr7:133106180 EXOC4 0.46 7.18 0.37 4.58e-12 Intelligence (multi-trait analysis); CRC cis rs769267 0.895 rs1000237 chr19:19518316 T/A cg01262667 chr19:19385393 TM6SF2 0.37 6.2 0.32 1.7e-9 Tonsillectomy; CRC cis rs1580019 0.587 rs7806941 chr7:32553319 G/T cg07520158 chr7:32535189 LSM5;AVL9 0.53 7.87 0.4 5.26e-14 Cognitive ability; CRC cis rs8180040 0.805 rs17410853 chr3:47363971 G/T cg27129171 chr3:47204927 SETD2 -0.56 -8.23 -0.41 4.52e-15 Colorectal cancer; CRC cis rs9462027 0.628 rs1125341 chr6:34786305 C/T cg07306190 chr6:34760872 UHRF1BP1 -0.34 -6.09 -0.32 3.16e-9 Systemic lupus erythematosus; CRC cis rs6570726 0.791 rs9403734 chr6:145931459 C/G cg13319975 chr6:146136371 FBXO30 -0.45 -6.7 -0.35 9.11e-11 Lobe attachment (rater-scored or self-reported); CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg16655837 chr10:32636197 EPC1 0.44 6.25 0.33 1.26e-9 Anxiety disorder; CRC cis rs2980439 0.818 rs2948294 chr8:8094961 A/G cg06636001 chr8:8085503 FLJ10661 0.74 11.87 0.55 2.63e-27 Neuroticism; CRC cis rs6951245 1.000 rs1881123 chr7:1084706 C/T cg18402987 chr7:1209562 NA 0.65 6.84 0.35 3.98e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs951366 0.764 rs708724 chr1:205743663 A/C cg11965913 chr1:205819406 PM20D1 0.84 13.86 0.61 1e-34 Menarche (age at onset); CRC cis rs754466 0.606 rs11002308 chr10:79594796 A/T cg17075019 chr10:79541650 NA -0.99 -18.12 -0.71 2.27e-51 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs9354308 0.901 rs2814096 chr6:66566131 G/A cg07460842 chr6:66804631 NA 0.47 5.85 0.31 1.17e-8 Metabolite levels; CRC cis rs823143 0.570 rs823084 chr1:205798313 G/T cg07167872 chr1:205819463 PM20D1 0.61 9.49 0.46 4.93e-19 Monocyte percentage of white cells; CRC cis rs9488822 0.636 rs12524932 chr6:116330266 G/A cg15226275 chr6:116381976 FRK 0.3 8.52 0.42 6e-16 Cholesterol, total;LDL cholesterol; CRC cis rs832540 0.564 rs33329 chr5:56145068 T/C cg20203395 chr5:56204925 C5orf35 -0.46 -6.35 -0.33 7.36e-10 Coronary artery disease; CRC cis rs6545883 0.895 rs4430924 chr2:61703856 A/G cg15711740 chr2:61764176 XPO1 -0.46 -5.93 -0.31 7.51e-9 Tuberculosis; CRC cis rs58804349 0.685 rs11239855 chr10:43483879 A/G cg20628663 chr10:43360327 NA -0.52 -5.65 -0.3 3.46e-8 Pediatric bone mineral content (radius); CRC trans rs61931739 0.500 rs6416261 chr12:34540377 T/C cg26384229 chr12:38710491 ALG10B 0.59 8.77 0.44 9.64e-17 Morning vs. evening chronotype; CRC cis rs995000 0.899 rs1168027 chr1:62970184 T/C cg19896129 chr1:63156450 NA -0.45 -6.99 -0.36 1.5e-11 Triglyceride levels; CRC cis rs76419734 0.510 rs2553456 chr4:106751028 T/C cg24545054 chr4:106630052 GSTCD;INTS12 -0.59 -6.93 -0.36 2.26e-11 Post bronchodilator FEV1; CRC cis rs6088590 1.000 rs6088590 chr20:33313566 T/C cg24642439 chr20:33292090 TP53INP2 0.59 10.59 0.5 9.79e-23 Coronary artery disease; CRC cis rs589448 0.902 rs315113 chr12:69786543 G/T cg14784868 chr12:69753453 YEATS4 -0.88 -16.77 -0.68 4.53e-46 Cerebrospinal fluid biomarker levels; CRC trans rs8002861 0.967 rs7321596 chr13:44472255 G/A cg17145862 chr1:211918768 LPGAT1 0.78 15.73 0.66 5.98e-42 Leprosy; CRC cis rs7811142 0.943 rs10241492 chr7:99994813 A/G cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.96 12.76 0.58 1.44e-30 Platelet count; CRC cis rs7618915 0.547 rs11709448 chr3:52647449 T/C cg18404041 chr3:52824283 ITIH1 -0.43 -8.93 -0.44 2.97e-17 Bipolar disorder; CRC cis rs10046574 0.516 rs7802453 chr7:135200638 T/C cg27474649 chr7:135195673 CNOT4 0.67 6.29 0.33 9.88e-10 Peripheral arterial disease (traffic-related air pollution interaction); CRC trans rs4650994 1.000 rs4077194 chr1:178533832 A/C cg05059571 chr16:84539110 KIAA1609 0.41 6.02 0.31 4.75e-9 HDL cholesterol levels;HDL cholesterol; CRC trans rs7726839 0.507 rs111707179 chr5:593308 T/A cg25482853 chr8:67687455 SGK3 1.08 12.84 0.58 6.96e-31 Obesity-related traits; CRC cis rs12142240 0.698 rs72677592 chr1:46818288 A/G cg14993813 chr1:46806288 NSUN4 -0.49 -6.23 -0.32 1.4e-9 Menopause (age at onset); CRC cis rs7618501 0.633 rs7628058 chr3:50039474 C/T cg24110177 chr3:50126178 RBM5 -0.47 -7.06 -0.36 1e-11 Intelligence (multi-trait analysis); CRC cis rs7666738 0.830 rs7664305 chr4:99037691 G/A cg05340658 chr4:99064831 C4orf37 0.61 9.43 0.46 7.65e-19 Colonoscopy-negative controls vs population controls; CRC cis rs11098499 0.818 rs55825515 chr4:120486402 A/G cg24375607 chr4:120327624 NA 0.49 7.35 0.38 1.61e-12 Corneal astigmatism; CRC cis rs7044106 0.791 rs10984998 chr9:123481516 G/C cg14255062 chr9:123606675 PSMD5;LOC253039 0.49 7.43 0.38 9.15e-13 Hip circumference adjusted for BMI; CRC cis rs9400271 0.609 rs9386782 chr6:109588643 G/T cg01475377 chr6:109611718 NA -0.35 -6.09 -0.32 3.18e-9 Sum neutrophil eosinophil counts;Sum basophil neutrophil counts;White blood cell count;Neutrophil count;Myeloid white cell count;Granulocyte count; CRC cis rs1552244 0.882 rs61429272 chr3:10037320 G/C cg10729496 chr3:10149963 C3orf24 0.49 6.34 0.33 7.69e-10 Alzheimer's disease; CRC cis rs11645898 0.810 rs72787046 chr16:72079342 A/G cg14768367 chr16:72042858 DHODH -0.74 -7.65 -0.39 2.23e-13 Blood protein levels; CRC cis rs2933343 0.859 rs789247 chr3:128580585 C/A cg11901034 chr3:128598214 ACAD9 -0.49 -6.09 -0.32 3.11e-9 IgG glycosylation; CRC cis rs7843479 0.870 rs1809498 chr8:21836384 C/G cg17168535 chr8:21777572 XPO7 -0.54 -8.85 -0.44 5.38e-17 Mean corpuscular volume; CRC cis rs2739330 0.828 rs4822454 chr22:24255208 G/A cg16132339 chr22:24313637 DDTL;DDT 0.62 10.21 0.49 1.99e-21 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs2032447 0.714 rs199725 chr6:25953684 A/G cg03264133 chr6:25882463 NA -0.46 -6.39 -0.33 5.56e-10 Intelligence (multi-trait analysis); CRC cis rs7618915 0.508 rs11717043 chr3:52656092 A/T cg10802521 chr3:52805072 NEK4 -0.58 -8.98 -0.44 2.11e-17 Bipolar disorder; CRC cis rs1223397 0.938 rs35549743 chr6:13294354 C/T cg21538684 chr6:13274180 PHACTR1 0.47 5.6 0.3 4.42e-8 Blood pressure; CRC cis rs798554 0.591 rs1713913 chr7:2895627 C/T cg19717773 chr7:2847554 GNA12 -0.36 -5.88 -0.31 1.01e-8 Height; CRC cis rs929354 0.772 rs6459738 chr7:156998532 T/G cg16102536 chr7:156981717 UBE3C 0.4 6.77 0.35 5.77e-11 Body mass index; CRC cis rs7542091 0.704 rs12022221 chr1:210046178 A/C cg22029157 chr1:209979665 IRF6 0.46 7.2 0.37 4.18e-12 Monobrow; CRC trans rs8073060 0.586 rs225257 chr17:33956625 G/A cg19694781 chr19:47549865 TMEM160 -1.05 -14.7 -0.63 5.76e-38 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; CRC cis rs7927592 0.956 rs10896334 chr11:68281494 C/T cg01657329 chr11:68192670 LRP5 -0.47 -6.69 -0.35 9.35e-11 Total body bone mineral density; CRC cis rs11098499 0.909 rs10017335 chr4:120381523 C/G cg24375607 chr4:120327624 NA -0.49 -7.46 -0.38 8.02e-13 Corneal astigmatism; CRC trans rs7618501 0.633 rs12496973 chr3:50002245 T/C cg21665057 chr3:196295764 WDR53;FBXO45 0.58 9.27 0.46 2.53e-18 Intelligence (multi-trait analysis); CRC cis rs9359856 0.564 rs17292425 chr6:90372128 A/G cg13799429 chr6:90582589 CASP8AP2 -0.73 -7.32 -0.37 1.89e-12 Bipolar disorder; CRC cis rs7927592 0.956 rs10896343 chr11:68317860 G/C cg01657329 chr11:68192670 LRP5 -0.48 -6.86 -0.35 3.35e-11 Total body bone mineral density; CRC cis rs873946 0.586 rs12770021 chr10:134562021 G/A cg27286337 chr10:134555280 INPP5A 0.84 10.24 0.49 1.58e-21 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CRC cis rs2074585 0.839 rs11638780 chr15:91041896 G/T cg22089800 chr15:90895588 ZNF774 -0.57 -9.51 -0.46 4.26e-19 Basophil percentage of granulocytes;White blood cell count (basophil);Basophil percentage of white cells; CRC cis rs2228479 0.557 rs12933317 chr16:89828220 A/G cg06656553 chr16:89960601 TCF25 -0.7 -5.77 -0.3 1.82e-8 Skin colour saturation; CRC cis rs1190552 0.846 rs1061924 chr14:102975655 C/T cg18135206 chr14:102964638 TECPR2 0.52 6.19 0.32 1.81e-9 Blood protein levels; CRC cis rs2949837 0.603 rs1542818 chr7:45977656 G/T cg04796162 chr7:45961102 IGFBP3 0.4 6.83 0.35 4.07e-11 Sitting height ratio; CRC cis rs950169 0.920 rs12915390 chr15:84792069 T/C cg24253500 chr15:84953950 NA 0.37 6.28 0.33 1.1e-9 Schizophrenia; CRC cis rs2404602 0.716 rs12907805 chr15:76690606 C/T cg03037974 chr15:76606532 NA 0.72 12.63 0.57 4.47e-30 Blood metabolite levels; CRC cis rs2898681 0.528 rs73814883 chr4:53728054 G/C cg00791764 chr4:53727839 RASL11B 0.59 6.39 0.33 5.8e-10 Optic nerve measurement (cup area); CRC trans rs6703335 0.870 rs10803142 chr1:243598234 A/G cg10684905 chr12:2999782 TULP3 0.41 5.99 0.31 5.49e-9 Schizophrenia;Schizophrenia, schizoaffective disorder or bipolar disorder; CRC cis rs6502050 0.799 rs9675196 chr17:80096655 C/T cg09264619 chr17:80180166 NA -0.34 -5.61 -0.3 4.21e-8 Life satisfaction; CRC cis rs79839061 0.610 rs11731387 chr4:851357 C/T cg14530993 chr4:882597 GAK 0.82 7.93 0.4 3.4e-14 Intelligence (multi-trait analysis); CRC cis rs4243830 1.000 rs12046884 chr1:6594561 G/A cg22792644 chr1:6614718 TAS1R1;NOL9 0.81 7.89 0.4 4.67e-14 Body mass index; CRC cis rs10979 1.000 rs10979 chr6:143890039 G/A cg25407410 chr6:143891975 LOC285740 -0.82 -13.4 -0.59 5.5e-33 Hypospadias; CRC cis rs1670533 1.000 rs7679432 chr4:1050521 G/A cg27284194 chr4:1044797 NA 0.51 6.23 0.33 1.39e-9 Recombination rate (females); CRC cis rs524281 0.861 rs3862386 chr11:65894424 G/C cg16950941 chr11:66035639 RAB1B -0.62 -7.51 -0.38 5.54e-13 Electroencephalogram traits; CRC cis rs2795502 0.564 rs3004259 chr10:43486041 A/G cg08461752 chr10:43522343 NA 0.82 7.5 0.38 6.04e-13 Blood protein levels; CRC cis rs2032447 0.901 rs2213284 chr6:26031868 G/A cg12310025 chr6:25882481 NA -0.53 -7.39 -0.38 1.23e-12 Intelligence (multi-trait analysis); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg07789552 chr1:36851195 STK40 0.42 5.98 0.31 5.93e-9 Intelligence (multi-trait analysis); CRC trans rs7618501 0.633 rs3774733 chr3:50037123 C/G cg21659725 chr3:3221576 CRBN 0.6 9.38 0.46 1.09e-18 Intelligence (multi-trait analysis); CRC cis rs875971 0.660 rs7807930 chr7:66087165 C/T cg11764359 chr7:65958608 NA -0.54 -8.33 -0.42 2.19e-15 Aortic root size; CRC cis rs8060686 0.516 rs7189794 chr16:68277727 T/C cg26727032 chr16:67993705 SLC12A4 -0.62 -8.8 -0.44 8.12e-17 HDL cholesterol;Metabolic syndrome; CRC cis rs559928 0.606 rs12417635 chr11:63912728 C/T cg19465662 chr11:63993652 NUDT22;TRPT1 0.7 6.72 0.35 7.98e-11 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; CRC cis rs1580019 0.885 rs4580942 chr7:32496435 A/G cg07520158 chr7:32535189 LSM5;AVL9 0.45 6.48 0.34 3.44e-10 Cognitive ability; CRC cis rs394563 0.690 rs237010 chr6:149758750 G/T cg07828024 chr6:149772892 ZC3H12D -0.53 -10.07 -0.49 5.53e-21 Dupuytren's disease; CRC cis rs4862750 0.624 rs34414639 chr4:187873417 C/A cg06074448 chr4:187884817 NA -0.59 -10.95 -0.52 5.1900000000000004e-24 Lobe attachment (rater-scored or self-reported); CRC cis rs11758351 0.587 rs16891456 chr6:26234127 T/C cg10723962 chr6:26240782 HIST1H4F -0.39 -6.27 -0.33 1.15e-9 Gout;Renal underexcretion gout; CRC cis rs10504229 0.683 rs67077711 chr8:58139769 G/T cg02290350 chr8:58132656 NA -0.58 -8.16 -0.41 7.29e-15 Developmental language disorder (linguistic errors); CRC cis rs1059312 0.808 rs12831705 chr12:129294905 G/A cg04043695 chr12:129287642 SLC15A4 0.37 5.66 0.3 3.32e-8 Systemic lupus erythematosus; CRC cis rs13108904 0.560 rs11247994 chr4:1343720 G/A cg21620606 chr4:1342894 KIAA1530 0.51 8.23 0.41 4.33e-15 Obesity-related traits; CRC trans rs7800418 0.753 rs730558 chr7:26588153 A/C cg14387656 chr2:233470847 EFHD1 0.46 6.37 0.33 6.36e-10 Cognitive function; CRC cis rs1580019 0.961 rs1580022 chr7:32497712 C/A cg06627557 chr7:32535165 LSM5;AVL9 0.71 11.2 0.53 6.71e-25 Cognitive ability; CRC cis rs1005277 0.528 rs2057228 chr10:38515766 T/C cg25427524 chr10:38739819 LOC399744 -0.79 -14.49 -0.62 3.78e-37 Extrinsic epigenetic age acceleration; CRC cis rs853679 0.760 rs9357067 chr6:28210293 C/G cg25164649 chr6:28176230 NA 0.55 5.75 0.3 2e-8 Depression; CRC cis rs12711979 0.765 rs6705742 chr2:3820672 C/T cg17052675 chr2:3827356 NA -0.56 -10.69 -0.51 4.47e-23 Itch intensity from mosquito bite adjusted by bite size; CRC cis rs72781680 1.000 rs7594510 chr2:24173377 A/G cg08917208 chr2:24149416 ATAD2B 0.91 9.24 0.45 3.06e-18 Lymphocyte counts; CRC cis rs6121246 0.909 rs1994251 chr20:30287328 T/G cg13852791 chr20:30311386 BCL2L1 0.68 10.77 0.51 2.29e-23 Mean corpuscular hemoglobin; CRC cis rs10191773 0.589 rs6761440 chr2:112959193 G/A cg24977338 chr2:113188963 RGPD8;RGPD5 -0.69 -6.1 -0.32 2.91e-9 Yeast infection; CRC cis rs10771431 0.817 rs17202253 chr12:9361850 A/G cg08997352 chr12:9597637 DDX12 -0.46 -6.99 -0.36 1.58e-11 Breast size; CRC cis rs2635047 0.638 rs9956809 chr18:44655843 A/G cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.37 5.71 0.3 2.57e-8 Educational attainment; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg12097945 chr11:10562746 RNF141 0.45 6.3 0.33 9.74e-10 Anxiety disorder; CRC cis rs9916302 0.904 rs8079560 chr17:37497661 C/T cg15445000 chr17:37608096 MED1 -0.44 -9.75 -0.47 6.95e-20 Glomerular filtration rate (creatinine); CRC cis rs6502050 0.871 rs62079998 chr17:80077245 A/C cg02741985 chr17:80059408 CCDC57 -0.45 -7.43 -0.38 9.53e-13 Life satisfaction; CRC trans rs7613875 0.641 rs2624845 chr3:50062437 C/A cg21659725 chr3:3221576 CRBN -0.45 -6.54 -0.34 2.29e-10 Body mass index; CRC cis rs4713118 0.662 rs9468275 chr6:28026136 G/T cg03623178 chr6:28175578 NA 0.92 13.02 0.58 1.52e-31 Parkinson's disease; CRC cis rs4285028 0.731 rs2877561 chr3:121712051 A/C cg11130432 chr3:121712080 ILDR1 0.55 7.26 0.37 2.86e-12 Multiple sclerosis; CRC cis rs11098499 0.604 rs34278750 chr4:120571136 G/A cg09307838 chr4:120376055 NA 0.67 9.81 0.48 4.26e-20 Corneal astigmatism; CRC cis rs9905704 0.918 rs390524 chr17:56674173 A/G cg12560992 chr17:57184187 TRIM37 0.56 7.78 0.39 9.44e-14 Testicular germ cell tumor; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg05351267 chr16:1877388 HAGH;FAHD1 0.47 6.35 0.33 7.15e-10 Anxiety disorder; CRC cis rs344364 0.511 rs2982453 chr16:1949520 G/A cg03013636 chr16:1946785 NA 0.58 7.08 0.36 8.69e-12 Glomerular filtration rate in chronic kidney disease; CRC cis rs1577917 0.958 rs12216074 chr6:86520002 C/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.52 -6.77 -0.35 5.8e-11 Response to antipsychotic treatment; CRC cis rs4629180 0.544 rs7595274 chr2:102140086 T/C cg04415270 chr2:102091202 RFX8 -0.36 -5.99 -0.31 5.65e-9 Chronic rhinosinusitis with nasal polyps; CRC cis rs67311347 0.955 rs2123999 chr3:40378738 C/T cg24209194 chr3:40518798 ZNF619 0.43 6.45 0.34 3.99e-10 Renal cell carcinoma; CRC cis rs8105895 0.935 rs10406485 chr19:22245002 G/T cg02657401 chr19:22469223 NA -0.34 -5.63 -0.3 3.83e-8 Body mass index (change over time); CRC cis rs938554 0.876 rs6449139 chr4:9934111 A/C cg00071950 chr4:10020882 SLC2A9 -0.4 -5.63 -0.3 3.94e-8 Blood metabolite levels; CRC cis rs250677 0.641 rs2915807 chr5:148450950 A/G cg18129178 chr5:148520854 ABLIM3 -0.4 -6.02 -0.32 4.56e-9 Breast cancer; CRC cis rs78456975 0.527 rs10184112 chr2:1571112 A/G cg12573674 chr2:1569213 NA -0.82 -10.94 -0.52 5.91e-24 Placebo response in major depressive disorder (% change in symptom score); CRC cis rs17155006 0.655 rs389486 chr7:107727804 C/G cg05962710 chr7:107745446 LAMB4 -0.35 -5.87 -0.31 1.04e-8 Pneumococcal bacteremia; CRC trans rs7395662 0.963 rs11039937 chr11:48712582 G/A cg21153622 chr11:89784906 NA -0.48 -7.72 -0.39 1.45e-13 HDL cholesterol; CRC cis rs2797160 0.651 rs6569437 chr6:126034540 T/G cg05901451 chr6:126070800 HEY2 0.52 8.4 0.42 1.37e-15 Endometrial cancer; CRC cis rs9818758 0.607 rs11719220 chr3:49245201 A/G cg07636037 chr3:49044803 WDR6 -0.67 -5.8 -0.3 1.59e-8 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; CRC cis rs7617773 0.780 rs3731489 chr3:48228906 C/A cg11946769 chr3:48343235 NME6 0.71 9.59 0.47 2.25e-19 Coronary artery disease; CRC cis rs3087591 0.708 rs2525563 chr17:29647908 T/G cg24425628 chr17:29625626 OMG;NF1 0.73 13.45 0.6 3.52e-33 Hip circumference; CRC cis rs4664293 0.605 rs890095 chr2:160461219 A/G cg08347373 chr2:160653686 CD302 0.36 5.88 0.31 9.85e-9 Monocyte percentage of white cells; CRC cis rs3820068 0.603 rs6696286 chr1:15968770 C/T cg13390004 chr1:15929781 NA 0.5 7.2 0.37 4.18e-12 Systolic blood pressure; CRC trans rs17192198 0.613 rs73196656 chr12:89996381 C/T cg17836913 chr1:54723679 SSBP3 -0.49 -6.19 -0.32 1.82e-9 Diastolic blood pressure; CRC cis rs17384381 1.000 rs12128907 chr1:85891385 A/G cg16011679 chr1:85725395 C1orf52 0.64 6.58 0.34 1.81e-10 Lobe attachment (rater-scored or self-reported); CRC cis rs6500602 0.702 rs11076835 chr16:4549618 G/A cg14951292 chr16:4525986 HMOX2;NMRAL1 0.57 8.75 0.43 1.12e-16 Schizophrenia; CRC cis rs7264396 0.887 rs736032 chr20:34048661 C/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.39 -6.41 -0.33 5.12e-10 Total cholesterol levels; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg23193153 chr6:34192178 NA 0.43 6.15 0.32 2.22e-9 Intelligence (multi-trait analysis); CRC cis rs9311474 0.607 rs4475032 chr3:52560021 C/T cg10802521 chr3:52805072 NEK4 -0.53 -8.18 -0.41 6.23e-15 Electroencephalogram traits; CRC trans rs2228479 0.850 rs11642010 chr16:89845111 T/C cg24644049 chr4:85504048 CDS1 0.92 7.13 0.37 6.52e-12 Skin colour saturation; CRC cis rs6089584 0.888 rs6142927 chr20:60605848 A/G cg13770153 chr20:60521292 NA -0.64 -9.04 -0.45 1.42e-17 Body mass index; CRC cis rs4363385 0.818 rs1415966 chr1:153002864 A/G cg25856811 chr1:152973957 SPRR3 -0.26 -7.16 -0.37 5.44e-12 Inflammatory skin disease; CRC cis rs4862750 0.872 rs13110072 chr4:187878524 A/G cg27532560 chr4:187881888 NA -0.55 -10.06 -0.48 6.26e-21 Lobe attachment (rater-scored or self-reported); CRC cis rs765787 0.530 rs1648289 chr15:45516494 A/G cg24006582 chr15:45444508 DUOX1 -0.53 -8.36 -0.42 1.78e-15 Uric acid levels; CRC cis rs4713118 0.869 rs9366700 chr6:27696951 C/T cg25164649 chr6:28176230 NA 0.58 8.19 0.41 5.97e-15 Parkinson's disease; CRC cis rs7584330 0.554 rs10190935 chr2:238435482 G/A cg14458575 chr2:238380390 NA 0.51 6.78 0.35 5.68e-11 Prostate cancer; CRC cis rs908922 0.676 rs486283 chr1:152525957 A/G cg23254163 chr1:152506842 NA 0.45 9.13 0.45 6.92e-18 Hair morphology; CRC cis rs6088580 0.634 rs6088488 chr20:32992631 T/C cg08999081 chr20:33150536 PIGU -0.6 -11.21 -0.53 6.38e-25 Glomerular filtration rate (creatinine); CRC cis rs6461049 0.765 rs4719431 chr7:2140312 T/C cg21782813 chr7:2030301 MAD1L1 0.43 7.73 0.39 1.35e-13 Schizophrenia; CRC trans rs7395662 1.000 rs4882117 chr11:48565468 G/T cg21153622 chr11:89784906 NA -0.47 -7.58 -0.39 3.59e-13 HDL cholesterol; CRC cis rs7584330 0.554 rs76980036 chr2:238426750 G/A cg08992911 chr2:238395768 MLPH 0.47 5.76 0.3 1.89e-8 Prostate cancer; CRC trans rs875971 0.660 rs2191268 chr7:66110224 C/T cg04036462 chr19:55691490 SYT5 -0.4 -6.15 -0.32 2.3e-9 Aortic root size; CRC cis rs9916302 0.904 rs8065963 chr17:37681332 C/T cg00129232 chr17:37814104 STARD3 -0.54 -8.08 -0.41 1.26e-14 Glomerular filtration rate (creatinine); CRC trans rs7267979 1.000 rs2474777 chr20:25272633 A/G cg17903999 chr18:56338584 MALT1 -0.41 -6.96 -0.36 1.83e-11 Liver enzyme levels (alkaline phosphatase); CRC trans rs34043159 0.898 rs7594775 chr2:102300940 T/C cg23013864 chr6:17393396 CAP2 0.41 6.06 0.32 3.8e-9 Parkinson's disease; CRC cis rs1348850 0.914 rs10170667 chr2:178336878 A/G cg02961200 chr2:178257176 LOC100130691;AGPS 0.64 9.26 0.45 2.68e-18 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs2084898 0.550 rs470411 chr11:120012390 G/C cg16005559 chr11:120040616 NA -0.55 -7.62 -0.39 2.68e-13 Stroke (pediatric); CRC cis rs1506636 1.000 rs635072 chr7:123403255 G/A cg03229431 chr7:123269106 ASB15 0.73 11.71 0.54 1.03e-26 Plateletcrit;Platelet count; CRC cis rs250677 0.958 rs36078 chr5:148430567 G/A cg18129178 chr5:148520854 ABLIM3 -0.38 -5.85 -0.31 1.19e-8 Breast cancer; CRC cis rs919433 1.000 rs6741380 chr2:198165121 A/G cg03934865 chr2:198174659 NA 0.42 7.51 0.38 5.5e-13 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC cis rs11587400 0.574 rs2268696 chr1:115219083 T/A cg12756093 chr1:115239321 AMPD1 -0.45 -6.08 -0.32 3.26e-9 Autism; CRC cis rs1552244 0.554 rs6768339 chr3:10006079 G/T cg18598329 chr3:10140678 FANCD2;C3orf24 0.49 6.93 0.36 2.27e-11 Alzheimer's disease; CRC cis rs35146811 0.625 rs858514 chr7:99825748 A/G cg00553149 chr7:99775558 STAG3;GPC2 -0.25 -5.72 -0.3 2.38e-8 Coronary artery disease; CRC trans rs7267979 1.000 rs4815406 chr20:25341316 C/G cg17903999 chr18:56338584 MALT1 0.43 7.12 0.37 6.83e-12 Liver enzyme levels (alkaline phosphatase); CRC cis rs185694 1.000 rs595449 chr13:30896852 T/C cg04551440 chr13:30881194 KATNAL1 -0.61 -6.29 -0.33 9.97e-10 Antineutrophil cytoplasmic antibody-associated vasculitis; CRC cis rs2108225 0.837 rs7810937 chr7:107447500 A/G cg18560240 chr7:107437656 SLC26A3 -0.67 -10.23 -0.49 1.7e-21 Ulcerative colitis; CRC cis rs28386778 0.897 rs6504184 chr17:61842408 A/T cg23090583 chr17:61904693 PSMC5;FTSJ3 1.05 20.23 0.74 1.07e-59 Prudent dietary pattern; CRC cis rs9611565 0.649 rs202645 chr22:41798520 A/G cg03806693 chr22:41940476 POLR3H 1.1 13.67 0.6 5.46e-34 Vitiligo; CRC trans rs9329221 0.772 rs7824675 chr8:10243418 G/T cg16141378 chr3:129829833 LOC729375 0.43 6.63 0.34 1.39e-10 Neuroticism; CRC cis rs733592 0.560 rs61918773 chr12:48421774 G/A cg15465823 chr12:48382534 COL2A1 -0.34 -5.62 -0.3 3.97e-8 Plateletcrit; CRC cis rs9399135 0.967 rs4388304 chr6:135309597 T/A cg22676075 chr6:135203613 NA 0.43 6.64 0.34 1.28e-10 Red blood cell count; CRC trans rs951252 0.504 rs11734405 chr4:146081096 C/T cg07369507 chr6:28304287 ZNF323 0.5 6.41 0.33 5.04e-10 Hip circumference; CRC cis rs763014 0.966 rs4984904 chr16:680809 C/G cg00908189 chr16:619842 PIGQ 0.66 10.62 0.51 7.39e-23 Height; CRC cis rs2882667 0.858 rs11741150 chr5:138431457 C/T cg04439458 chr5:138467593 SIL1 -0.35 -5.97 -0.31 6.02e-9 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs10883723 0.775 rs7917158 chr10:104246471 C/A cg11453585 chr10:104263688 ACTR1A;SUFU 0.91 17.46 0.69 8.83e-49 Allergic disease (asthma, hay fever or eczema); CRC cis rs501120 0.584 rs556434 chr10:44732519 T/A cg09554077 chr10:44749378 NA 0.64 7.06 0.36 9.82e-12 Coronary artery disease;Coronary heart disease; CRC cis rs3820068 0.553 rs7545782 chr1:15955227 G/C cg27534772 chr1:16042836 PLEKHM2 0.55 10.94 0.52 5.59e-24 Systolic blood pressure; CRC cis rs698833 0.859 rs1302175 chr2:44657024 G/C cg04920474 chr2:44395004 PPM1B 0.39 5.7 0.3 2.74e-8 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; CRC cis rs9322817 0.583 rs6941988 chr6:105146656 C/T cg02098413 chr6:105308735 HACE1 0.44 8.78 0.44 9.23e-17 Thyroid stimulating hormone; CRC cis rs12421382 0.543 rs10890996 chr11:109328421 A/G cg27471124 chr11:109292789 C11orf87 -0.32 -6.34 -0.33 7.41e-10 Schizophrenia; CRC cis rs780096 0.546 rs1260320 chr2:27722416 A/G cg17158414 chr2:27665306 KRTCAP3 0.26 5.68 0.3 2.96e-8 Total body bone mineral density; CRC cis rs4563143 0.704 rs16961809 chr19:29226299 C/T cg03161606 chr19:29218774 NA 0.63 8.4 0.42 1.39e-15 Methadone dose in opioid dependence; CRC cis rs3768617 0.510 rs1547712 chr1:183088013 T/A ch.1.3577855R chr1:183094577 LAMC1 0.89 15.86 0.66 1.84e-42 Fuchs's corneal dystrophy; CRC cis rs769267 0.930 rs2301786 chr19:19413947 A/G cg20644253 chr19:19431407 KIAA0892;SF4 0.42 5.77 0.3 1.85e-8 Tonsillectomy; CRC cis rs754466 0.651 rs10824582 chr10:79603688 T/C cg17075019 chr10:79541650 NA -0.89 -15.31 -0.65 2.53e-40 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs7517126 0.920 rs6428365 chr1:196844131 C/A cg13682187 chr1:196946512 CFHR5 -0.37 -6.08 -0.32 3.39e-9 Blood protein levels; CRC cis rs853679 0.517 rs7755442 chr6:28039015 T/C cg12963246 chr6:28129442 ZNF389 0.48 5.7 0.3 2.72e-8 Depression; CRC cis rs4975616 0.836 rs460073 chr5:1336459 T/C cg26373071 chr5:1325741 CLPTM1L 0.55 10.21 0.49 1.97e-21 Lung cancer; CRC cis rs1862618 0.671 rs252897 chr5:56223000 G/A cg03609598 chr5:56110824 MAP3K1 -0.57 -7.56 -0.38 4.01e-13 Initial pursuit acceleration; CRC cis rs514406 0.683 rs6588440 chr1:53209587 C/T cg24675658 chr1:53192096 ZYG11B 0.67 10.37 0.5 5.31e-22 Monocyte count; CRC cis rs208520 1.000 rs12190187 chr6:66973207 T/G cg07460842 chr6:66804631 NA 0.92 11.38 0.53 1.56e-25 Exhaled nitric oxide output; CRC cis rs9303401 0.615 rs35288118 chr17:56600748 A/C cg02118635 chr17:56770003 RAD51C;TEX14 0.84 9.92 0.48 1.86e-20 Cognitive test performance; CRC cis rs10191773 0.589 rs72831641 chr2:112955815 A/G cg24977338 chr2:113188963 RGPD8;RGPD5 -0.64 -6.16 -0.32 2.14e-9 Yeast infection; CRC cis rs7680126 0.596 rs11722185 chr4:10317482 C/G cg00071950 chr4:10020882 SLC2A9 -0.48 -6.37 -0.33 6.38e-10 Urate levels in lean individuals;Urate levels in overweight individuals;Urate levels in obese individuals; CRC cis rs651907 0.557 rs34376498 chr3:101480156 C/T cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.58 7.73 0.39 1.35e-13 Colorectal cancer; CRC cis rs6460942 0.630 rs62448731 chr7:12341174 G/A cg20607287 chr7:12443886 VWDE -0.55 -5.98 -0.31 5.94e-9 Coronary artery disease; CRC cis rs9303401 0.538 rs12603174 chr17:56489279 T/C cg10487724 chr17:56770010 TEX14;RAD51C 0.71 8.62 0.43 2.78e-16 Cognitive test performance; CRC cis rs13191362 1.000 rs55822577 chr6:163069710 G/A cg21926612 chr6:163149169 PACRG;PARK2 0.97 12.69 0.57 2.66e-30 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs1707322 0.721 rs4660314 chr1:46229885 T/C cg06784218 chr1:46089804 CCDC17 0.66 12.29 0.56 7.69e-29 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC trans rs7618501 1.000 rs9855505 chr3:49792158 T/G cg21659725 chr3:3221576 CRBN -0.9 -17.21 -0.69 8.44e-48 Intelligence (multi-trait analysis); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg08614771 chr6:157100981 ARID1B 0.39 6.13 0.32 2.46e-9 Liver disease severity in Alagille syndrome; CRC cis rs6712932 1.000 rs6734358 chr2:105843732 A/C cg22878388 chr2:105853796 NA -0.31 -5.96 -0.31 6.51e-9 Type 2 diabetes; CRC cis rs753274 0.650 rs72998945 chr19:14418441 C/A cg25450033 chr19:14444658 NA 0.35 6.11 0.32 2.8e-9 Tumor necrosis factor beta levels; CRC cis rs1799949 1.000 rs2292595 chr17:41290674 G/C cg25072359 chr17:41440525 NA 0.46 6.96 0.36 1.87e-11 Menopause (age at onset); CRC cis rs10779751 0.770 rs10864490 chr1:11236410 A/C cg08854313 chr1:11322531 MTOR 0.59 7.66 0.39 2.12e-13 Body mass index; CRC cis rs798554 1.000 rs798548 chr7:2760935 A/G cg04166393 chr7:2884313 GNA12 0.45 6.44 0.33 4.17e-10 Height; CRC cis rs847649 1.000 rs28856331 chr7:102543763 T/G cg18108683 chr7:102477205 FBXL13 -0.57 -9.26 -0.45 2.8e-18 Morning vs. evening chronotype; CRC cis rs853679 0.699 rs9468318 chr6:28209531 T/A cg15845792 chr6:28175446 NA 0.74 7.78 0.39 9.45e-14 Depression; CRC cis rs6701037 0.566 rs729675 chr1:175136946 T/C cg17845761 chr1:175162550 KIAA0040 0.31 6.51 0.34 2.81e-10 Alcohol dependence; CRC cis rs7814319 0.933 rs13260865 chr8:97238472 A/T cg20787634 chr8:97240163 UQCRB -0.54 -9.55 -0.47 3.08e-19 Lung function (FVC); CRC cis rs988712 0.622 rs10767664 chr11:27725986 T/A cg10635145 chr11:27742435 BDNF 0.42 6.28 0.33 1.08e-9 Obesity; CRC cis rs13256369 0.901 rs4841015 chr8:8567140 C/G cg00074818 chr8:8560427 CLDN23 0.36 6.43 0.33 4.59e-10 Obesity-related traits; CRC cis rs889312 0.500 rs252905 chr5:56118875 C/T cg24531977 chr5:56204891 C5orf35 -0.44 -6.88 -0.35 2.99e-11 Breast cancer;Breast cancer (early onset); CRC cis rs6582630 0.502 rs4379906 chr12:38295673 G/A cg13010199 chr12:38710504 ALG10B 0.46 6.45 0.33 4.08e-10 Drug-induced liver injury (flucloxacillin); CRC cis rs11212617 0.967 rs113995 chr11:108256837 A/T cg14761454 chr11:108092087 ATM;NPAT 0.43 6.59 0.34 1.74e-10 Response to metformin in type 2 diabetes (glycemic); CRC cis rs2279817 0.818 rs34304724 chr1:17994850 C/T cg21791023 chr1:18019539 ARHGEF10L -0.53 -5.6 -0.3 4.45e-8 Neuroticism; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg12502759 chr12:99039019 APAF1;IKBIP 0.46 6.28 0.33 1.09e-9 Anxiety disorder; CRC cis rs7224685 0.501 rs8066272 chr17:3900528 C/T cg10724054 chr17:3904396 NA -0.46 -7.57 -0.39 3.71e-13 Type 2 diabetes; CRC cis rs798554 0.759 rs1636255 chr7:2892804 A/C cg19346786 chr7:2764209 NA 0.41 6.94 0.36 2.04e-11 Height; CRC cis rs10876993 0.928 rs1678540 chr12:58065002 A/G cg15848620 chr12:58087721 OS9 -0.62 -8.68 -0.43 1.91e-16 Celiac disease or Rheumatoid arthritis; CRC cis rs4664308 0.875 rs2124969 chr2:160989486 T/C cg03641300 chr2:160917029 PLA2R1 -0.74 -12.29 -0.56 7.62e-29 Idiopathic membranous nephropathy; CRC cis rs4523957 0.928 rs11872068 chr17:2176528 G/A cg16513277 chr17:2031491 SMG6 -0.55 -9.12 -0.45 7.52e-18 Autism spectrum disorder or schizophrenia;Schizophrenia; CRC cis rs2073300 0.609 rs56094936 chr20:23401586 G/A cg12062639 chr20:23401060 NAPB 0.84 7.59 0.39 3.31e-13 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs2635047 0.601 rs2576058 chr18:44641397 C/T cg19077165 chr18:44547161 KATNAL2 -0.39 -5.88 -0.31 9.9e-9 Educational attainment; CRC cis rs1865760 1.000 rs2071297 chr6:25924513 C/G cg17691542 chr6:26056736 HIST1H1C -0.56 -8.41 -0.42 1.24e-15 Height; CRC cis rs11105298 0.838 rs4842488 chr12:89881564 C/G cg08166232 chr12:89918718 WDR51B;GALNT4 -0.61 -7.81 -0.4 7.9e-14 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; CRC cis rs17767392 0.881 rs7157241 chr14:72001296 A/T cg13720639 chr14:72061746 SIPA1L1 -0.56 -7.19 -0.37 4.45e-12 Mitral valve prolapse; CRC cis rs7591163 1.000 rs6738964 chr2:228739135 G/T cg21577049 chr2:228736449 WDR69 -0.45 -5.98 -0.31 5.87e-9 Blood pressure; CRC cis rs908922 0.676 rs1123567 chr1:152516023 G/A cg09873164 chr1:152488093 CRCT1 0.4 6.72 0.35 8.09e-11 Hair morphology; CRC cis rs9549328 0.800 rs9549616 chr13:113627762 T/G cg25790453 chr13:113633590 MCF2L -0.57 -9.93 -0.48 1.73e-20 Systolic blood pressure; CRC cis rs9926296 0.568 rs1230 chr16:89804855 A/G cg21285383 chr16:89894308 SPIRE2 -0.37 -6.14 -0.32 2.32e-9 Vitiligo; CRC cis rs4654899 0.644 rs6669077 chr1:21290520 A/C cg02927042 chr1:21476669 EIF4G3 -0.39 -6.16 -0.32 2.16e-9 Superior frontal gyrus grey matter volume; CRC cis rs2050392 0.965 rs1543725 chr10:30698873 A/G cg25182066 chr10:30743637 MAP3K8 -0.39 -5.79 -0.3 1.64e-8 Inflammatory bowel disease; CRC cis rs6089584 0.853 rs1740367 chr20:60574834 C/T cg23463467 chr20:60627584 TAF4 0.33 5.61 0.3 4.27e-8 Body mass index; CRC cis rs9462846 0.881 rs113433755 chr6:42887558 A/G cg21280719 chr6:42927975 GNMT -0.35 -6.58 -0.34 1.88e-10 Blood protein levels; CRC cis rs34164109 1 rs34164109 chr6:135421176 C/T cg22676075 chr6:135203613 NA 0.52 6.6 0.34 1.62e-10 Red blood cell count;Reticulocyte fraction of red cells; CRC cis rs7927771 0.826 rs7925389 chr11:47466790 A/T cg05585544 chr11:47624801 NA -0.54 -9.69 -0.47 1.08e-19 Subjective well-being; CRC cis rs1577917 1.000 rs12154056 chr6:86634094 G/A cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.52 -6.78 -0.35 5.63e-11 Response to antipsychotic treatment; CRC trans rs6011368 0.840 rs2427638 chr20:62900717 C/T cg13869341 chr1:15865 WASH5P 0.52 8.06 0.41 1.39e-14 Clozapine-induced cytotoxicity; CRC cis rs17666538 0.535 rs1669658 chr8:607380 A/G cg13264159 chr8:625131 ERICH1 -0.77 -7.22 -0.37 3.52e-12 IgG glycosylation; CRC cis rs3091242 0.933 rs35497030 chr1:25783066 A/G cg23205692 chr1:25664452 TMEM50A -0.4 -5.66 -0.3 3.25e-8 Erythrocyte sedimentation rate; CRC cis rs1799949 1.000 rs8176133 chr17:41257458 A/C cg19454999 chr17:41278357 BRCA1;NBR2 0.55 8.56 0.43 4.37e-16 Menopause (age at onset); CRC cis rs3733585 0.699 rs1079128 chr4:9951221 T/C cg11266682 chr4:10021025 SLC2A9 -0.47 -9.69 -0.47 1.04e-19 Cleft plate (environmental tobacco smoke interaction); CRC cis rs1065852 0.526 rs12166549 chr22:42410419 T/C cg00645731 chr22:42541494 CYP2D7P1 0.4 6.92 0.36 2.36e-11 Response to serotonin reuptake inhibitors in major depressive disorder (plasma drug and metabolite levels); CRC cis rs7811142 0.830 rs1063945 chr7:99930447 C/T cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.13 16.05 0.66 3.27e-43 Platelet count; CRC cis rs2836974 0.796 rs77153312 chr21:40695499 G/A cg11890956 chr21:40555474 PSMG1 1.02 16.12 0.66 1.65e-43 Cognitive function; CRC cis rs4727027 0.835 rs6959224 chr7:148784495 A/G cg23583168 chr7:148888333 NA -0.8 -13.18 -0.59 3.72e-32 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC cis rs6762 0.642 rs28692469 chr11:839675 T/C cg15787769 chr11:842744 TSPAN4;POLR2L -0.47 -6.63 -0.34 1.36e-10 Mean platelet volume; CRC cis rs10208940 0.777 rs4513330 chr2:68850921 C/T cg12452813 chr2:68675892 NA -0.48 -6.11 -0.32 2.86e-9 Urate levels in lean individuals; CRC cis rs17253792 0.822 rs28409547 chr14:56047826 C/T cg24579896 chr14:56047964 C14orf33;KTN1 0.71 6.06 0.32 3.77e-9 Putamen volume; CRC cis rs17711722 0.522 rs6957759 chr7:65271785 A/G cg05627663 chr7:65219948 SNORA22;CCT6P1 0.66 10.19 0.49 2.26e-21 Calcium levels; CRC cis rs801193 0.569 rs2659892 chr7:66200305 A/G cg18252515 chr7:66147081 NA -0.41 -5.81 -0.3 1.5e-8 Aortic root size; CRC trans rs6601327 0.606 rs9644707 chr8:9590116 A/T cg06636001 chr8:8085503 FLJ10661 -0.49 -7.19 -0.37 4.5e-12 Multiple myeloma (hyperdiploidy); CRC cis rs6499255 1.000 rs6499255 chr16:69830328 A/G cg04110750 chr16:69646130 NFAT5 -0.49 -6.77 -0.35 5.77e-11 IgE levels; CRC cis rs2795502 0.630 rs3004257 chr10:43480529 C/T cg20628663 chr10:43360327 NA 0.61 6.94 0.36 2.13e-11 Blood protein levels; CRC cis rs13256369 1.000 rs10095733 chr8:8574646 A/G cg18904891 chr8:8559673 CLDN23 0.51 6.96 0.36 1.83e-11 Obesity-related traits; CRC trans rs1814175 0.817 rs7481230 chr11:49772235 G/A cg15704280 chr7:45808275 SEPT13 -0.98 -19.1 -0.73 2.93e-55 Height; CRC cis rs7412746 0.658 rs12067685 chr1:150952917 T/C cg10589385 chr1:150898437 SETDB1 0.31 6.49 0.34 3.08e-10 Melanoma; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg15214069 chr9:139333582 INPP5E 0.44 6.33 0.33 8.05e-10 Response to antipsychotic treatment; CRC cis rs7927592 0.956 rs7126340 chr11:68257293 C/T cg01657329 chr11:68192670 LRP5 -0.46 -6.69 -0.35 9.43e-11 Total body bone mineral density; CRC cis rs6479527 0.875 rs10435922 chr9:96781419 G/A cg14459158 chr9:96720562 NA 0.36 6.49 0.34 3.12e-10 Esophageal adenocarcinoma; CRC cis rs1552244 0.810 rs6809572 chr3:10100145 G/A cg16606324 chr3:10149918 C3orf24 0.72 9.82 0.48 3.92e-20 Alzheimer's disease; CRC cis rs11650494 0.634 rs8072520 chr17:47466640 T/G cg08112188 chr17:47440006 ZNF652 0.71 6.32 0.33 8.54e-10 Prostate cancer; CRC cis rs3806843 0.838 rs2563289 chr5:140122766 T/A cg19875535 chr5:140030758 IK -0.55 -9.11 -0.45 8.03e-18 Depressive symptoms (multi-trait analysis); CRC cis rs763121 0.853 rs2281021 chr22:39064667 T/C cg06022373 chr22:39101656 GTPBP1 0.8 12.71 0.57 2.19e-30 Menopause (age at onset); CRC cis rs1707322 0.752 rs28623463 chr1:46170758 A/C cg06784218 chr1:46089804 CCDC17 0.65 12.15 0.56 2.54e-28 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs7914558 0.966 rs10786727 chr10:104698523 G/A cg04362960 chr10:104952993 NT5C2 0.61 9.23 0.45 3.48e-18 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs950169 0.614 rs765524 chr15:84681782 G/T cg17507749 chr15:85114479 UBE2QP1 0.65 9.17 0.45 5.22e-18 Schizophrenia; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg14932796 chr17:55038330 COIL 0.49 6.36 0.33 6.9e-10 Thyroid stimulating hormone; CRC cis rs4665809 0.590 rs11552518 chr2:26455127 G/A cg26119090 chr2:26468346 HADHA;HADHB 1.06 15.53 0.65 3.62e-41 Gut microbiome composition (summer); CRC cis rs5753618 0.509 rs5997913 chr22:31593959 C/A cg22777020 chr22:31556080 RNF185 -0.53 -6.2 -0.32 1.72e-9 Colorectal cancer; CRC cis rs995000 0.931 rs6678483 chr1:63074442 C/A cg19896129 chr1:63156450 NA 0.42 6.53 0.34 2.48e-10 Triglyceride levels; CRC cis rs6963495 0.745 rs75805443 chr7:105162828 A/G cg13798780 chr7:105162888 PUS7 0.68 8.08 0.41 1.27e-14 Bipolar disorder (body mass index interaction); CRC cis rs832540 0.656 rs832567 chr5:56152416 C/A cg03609598 chr5:56110824 MAP3K1 -0.43 -5.8 -0.3 1.54e-8 Coronary artery disease; CRC cis rs7746199 0.736 rs6904596 chr6:27491299 G/A cg08798685 chr6:27730294 NA -0.68 -6.06 -0.32 3.83e-9 Gait speed in old age;Autism spectrum disorder or schizophrenia; CRC cis rs10463316 0.832 rs152087 chr5:150734419 C/T cg03212797 chr5:150827313 SLC36A1 -0.46 -6.94 -0.36 2.06e-11 Metabolite levels (Pyroglutamine); CRC cis rs9462846 1.000 rs9471942 chr6:42861532 C/T cg10862848 chr6:42927986 GNMT -0.3 -5.64 -0.3 3.75e-8 Blood protein levels; CRC cis rs4731207 0.535 rs28820311 chr7:124598989 C/G cg23710748 chr7:124431027 NA -0.38 -6.08 -0.32 3.35e-9 Cutaneous malignant melanoma; CRC cis rs7615952 0.599 rs67566088 chr3:125768973 C/A cg18479299 chr3:125709523 NA -0.55 -6.62 -0.34 1.45e-10 Blood pressure (smoking interaction); CRC cis rs7927771 1.000 rs10838747 chr11:47716324 G/C cg20307385 chr11:47447363 PSMC3 -0.51 -6.77 -0.35 6.01e-11 Subjective well-being; CRC cis rs933688 1.000 rs35712350 chr5:90679519 C/T cg26981201 chr5:90679533 LOC100129716;ARRDC3 1.08 17.64 0.7 1.78e-49 Smoking behavior; CRC cis rs6952808 0.609 rs10274300 chr7:1950405 C/G cg04267008 chr7:1944627 MAD1L1 -0.62 -9.63 -0.47 1.69e-19 Bipolar disorder and schizophrenia; CRC cis rs9486719 0.843 rs2499796 chr6:96848364 A/G cg06623918 chr6:96969491 KIAA0776 0.77 8.51 0.42 6.25e-16 Migraine;Coronary artery disease; CRC cis rs1862618 0.671 rs2591964 chr5:56236900 T/G cg12311346 chr5:56204834 C5orf35 0.65 9.72 0.47 8.55e-20 Initial pursuit acceleration; CRC cis rs6973256 0.568 rs7800126 chr7:133521356 A/C cg10665199 chr7:133106180 EXOC4 0.45 6.81 0.35 4.56e-11 Intelligence (multi-trait analysis); CRC trans rs877282 0.786 rs11253392 chr10:788768 G/A cg22713356 chr15:30763199 NA 1.35 16.39 0.67 1.43e-44 Uric acid levels; CRC cis rs10028773 0.568 rs6838457 chr4:120267367 A/G cg24375607 chr4:120327624 NA 0.47 7.68 0.39 1.89e-13 Educational attainment; CRC cis rs1559088 0.625 rs10411739 chr19:33616327 T/C cg27124370 chr19:33622961 WDR88 0.48 7.29 0.37 2.31e-12 Bone ultrasound measurement (broadband ultrasound attenuation); CRC cis rs11252926 0.617 rs11253319 chr10:722732 C/T cg18196295 chr10:418757 DIP2C -0.45 -6.05 -0.32 3.86e-9 Psychosis in Alzheimer's disease; CRC cis rs4803468 1.000 rs3810175 chr19:41904396 C/T cg09537434 chr19:41945824 ATP5SL 0.97 18.89 0.72 1.98e-54 Height; CRC trans rs1005277 0.540 rs11011351 chr10:38030525 A/G cg23533926 chr12:111358616 MYL2 -0.44 -6.45 -0.34 3.95e-10 Extrinsic epigenetic age acceleration; CRC cis rs1347297 0.666 rs10204497 chr2:179266127 G/A cg03991736 chr2:179345203 MIR548N;PLEKHA3 -0.42 -5.92 -0.31 8.1e-9 Alzheimer disease and age of onset; CRC cis rs13108904 0.935 rs2293633 chr4:1291640 T/C cg24560729 chr4:1342394 KIAA1530 0.33 6.19 0.32 1.78e-9 Obesity-related traits; CRC cis rs1862618 0.853 rs252921 chr5:56137787 G/A cg24531977 chr5:56204891 C5orf35 -0.8 -10.8 -0.51 1.79e-23 Initial pursuit acceleration; CRC cis rs6545883 0.826 rs1186697 chr2:61661417 G/A cg15711740 chr2:61764176 XPO1 -0.43 -5.63 -0.3 3.92e-8 Tuberculosis; CRC cis rs561341 0.941 rs2428336 chr17:30290577 T/C cg23018236 chr17:30244563 NA -0.58 -7.53 -0.38 5e-13 Hip circumference adjusted for BMI; CRC cis rs4731207 0.596 rs922713 chr7:124607059 A/T cg23710748 chr7:124431027 NA -0.39 -6.16 -0.32 2.14e-9 Cutaneous malignant melanoma; CRC cis rs7927771 0.524 rs12421563 chr11:47780222 G/A cg20307385 chr11:47447363 PSMC3 -0.45 -6.64 -0.34 1.28e-10 Subjective well-being; CRC cis rs72945132 0.882 rs60780459 chr11:70162468 A/G cg00319359 chr11:70116639 PPFIA1 0.67 7.46 0.38 7.95e-13 Coronary artery disease; CRC cis rs7927592 0.731 rs2840367 chr11:68302101 G/A cg16797656 chr11:68205561 LRP5 -0.48 -8.78 -0.44 9.05e-17 Total body bone mineral density; CRC cis rs3741151 1.000 rs3741151 chr11:73020846 G/T cg17517138 chr11:73019481 ARHGEF17 1.14 10.07 0.49 5.8e-21 GIP levels in response to oral glucose tolerance test (120 minutes); CRC cis rs66887589 0.870 rs2389875 chr4:120557014 G/T cg09307838 chr4:120376055 NA -0.5 -7.72 -0.39 1.45e-13 Diastolic blood pressure; CRC trans rs2228479 0.850 rs62052714 chr16:89857180 T/C cg24644049 chr4:85504048 CDS1 0.83 7.0 0.36 1.47e-11 Skin colour saturation; CRC cis rs3087591 0.919 rs2018624 chr17:29560777 T/G cg24425628 chr17:29625626 OMG;NF1 -0.84 -16.3 -0.67 3.4e-44 Hip circumference; CRC cis rs78456975 0.527 rs7590742 chr2:1575049 A/T cg12573674 chr2:1569213 NA -0.78 -10.48 -0.5 2.37e-22 Placebo response in major depressive disorder (% change in symptom score); CRC cis rs2380220 0.872 rs2613529 chr6:95945036 C/T cg04719120 chr6:96025338 MANEA -0.55 -6.04 -0.32 4.15e-9 Behavioural disinhibition (generation interaction); CRC cis rs3820068 0.581 rs6669417 chr1:15922371 G/T cg27534772 chr1:16042836 PLEKHM2 0.55 10.87 0.51 9.78e-24 Systolic blood pressure; CRC cis rs3741151 1.000 rs75912489 chr11:73073846 G/A cg17517138 chr11:73019481 ARHGEF17 1.12 9.63 0.47 1.74e-19 GIP levels in response to oral glucose tolerance test (120 minutes); CRC cis rs41271473 0.526 rs12094319 chr1:228717836 G/C cg16512390 chr1:228756714 NA 0.64 6.74 0.35 7.14e-11 Chronic lymphocytic leukemia; CRC cis rs875971 0.825 rs6951503 chr7:65718936 T/G cg11764359 chr7:65958608 NA -0.59 -8.68 -0.43 1.91e-16 Aortic root size; CRC cis rs7618915 0.571 rs17264436 chr3:52610651 T/A cg10802521 chr3:52805072 NEK4 -0.58 -9.01 -0.44 1.68e-17 Bipolar disorder; CRC cis rs262150 0.574 rs2730273 chr7:158797754 A/C cg04239562 chr7:158767014 NA 0.36 5.68 0.3 2.96e-8 Facial morphology (factor 20); CRC cis rs7247513 1.000 rs7247513 chr19:12691185 C/T cg01871581 chr19:12707946 ZNF490 -0.74 -12.41 -0.56 2.86e-29 Bipolar disorder; CRC cis rs7811142 0.830 rs6975660 chr7:99975266 A/G cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.14 17.06 0.69 3.53e-47 Platelet count; CRC cis rs1018836 1.000 rs1018836 chr8:91570362 A/G cg16814680 chr8:91681699 NA -0.6 -9.12 -0.45 7.49e-18 Ejection fraction in Tripanosoma cruzi seropositivity; CRC cis rs12541335 0.639 rs4871994 chr8:22206038 G/A cg02788857 chr8:22132959 PIWIL2 0.5 8.4 0.42 1.36e-15 Hypertriglyceridemia; CRC trans rs9341835 0.642 rs1723535 chr6:64136886 A/G cg13657004 chr13:50234944 EBPL -0.36 -6.17 -0.32 2.03e-9 Schizophrenia; CRC cis rs11677416 1.000 rs1800587 chr2:113542960 C/T cg27083787 chr2:113543245 IL1A 0.45 6.38 0.33 5.89e-10 Response to antipsychotic treatment in schizophrenia (working memory); CRC cis rs11212617 1.000 rs609429 chr11:108196509 G/C cg12106634 chr11:108092400 ATM;NPAT 0.43 6.43 0.33 4.42e-10 Response to metformin in type 2 diabetes (glycemic); CRC cis rs10992471 0.631 rs2296667 chr9:95274338 A/G cg14631576 chr9:95140430 CENPP -0.31 -5.87 -0.31 1.06e-8 Visceral adipose tissue/subcutaneous adipose tissue ratio; CRC cis rs908922 0.676 rs12059256 chr1:152515431 G/A cg09873164 chr1:152488093 CRCT1 0.39 6.58 0.34 1.84e-10 Hair morphology; CRC cis rs11997175 0.624 rs4733179 chr8:33692223 T/G cg04338863 chr8:33670619 NA 0.43 6.92 0.36 2.3e-11 Body mass index; CRC cis rs9462027 0.583 rs7755982 chr6:34715297 C/T cg07306190 chr6:34760872 UHRF1BP1 -0.35 -6.25 -0.33 1.28e-9 Systemic lupus erythematosus; CRC cis rs6502050 0.698 rs6502076 chr17:80121978 A/G cg25804541 chr17:80189381 SLC16A3 -0.31 -5.95 -0.31 6.84e-9 Life satisfaction; CRC cis rs490234 0.702 rs5016056 chr9:128310807 C/T cg14078157 chr9:128172775 NA -0.4 -6.63 -0.34 1.34e-10 Mean arterial pressure; CRC cis rs8018808 0.967 rs4903579 chr14:77850940 T/A cg20045696 chr14:77926864 AHSA1 -0.36 -5.6 -0.3 4.47e-8 Myeloid white cell count; CRC cis rs35110281 0.774 rs1378080 chr21:45011315 T/A cg01579765 chr21:45077557 HSF2BP -0.32 -6.06 -0.32 3.79e-9 Mean corpuscular volume; CRC cis rs3018066 0.692 rs28822186 chr4:107009482 G/A cg01869342 chr4:106983673 TBCK 0.44 6.7 0.35 9.19e-11 Cancer; CRC trans rs6951245 1.000 rs6951245 chr7:1058193 G/A cg13565492 chr6:43139072 SRF -0.7 -7.21 -0.37 3.77e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs6502050 0.835 rs9900072 chr17:80114360 C/G cg19223190 chr17:80058835 NA 0.38 6.18 0.32 1.94e-9 Life satisfaction; CRC cis rs7212590 0.655 rs62081824 chr17:57907950 A/G cg10252138 chr17:58120427 NA -0.54 -5.65 -0.3 3.51e-8 Granulocyte percentage of myeloid white cells;Monocyte count;Monocyte percentage of white cells; CRC cis rs533581 0.866 rs562812 chr16:88970944 G/A cg16701003 chr16:89028210 CBFA2T3 0.43 6.56 0.34 2.15e-10 Social autistic-like traits; CRC cis rs10751667 0.857 rs6597952 chr11:991109 C/G cg23136738 chr11:925521 AP2A2 -0.48 -7.63 -0.39 2.52e-13 Alzheimer's disease (late onset); CRC cis rs9469578 1.000 rs16869456 chr6:33714622 G/A cg18708504 chr6:33715942 IP6K3 0.66 7.56 0.38 4e-13 Phosphorus levels; CRC cis rs2180341 0.924 rs877661 chr6:127587915 T/G cg27446573 chr6:127587934 RNF146 0.99 14.57 0.63 1.87e-37 Breast cancer; CRC cis rs938554 0.736 rs11734219 chr4:9977154 C/T cg00071950 chr4:10020882 SLC2A9 0.47 6.65 0.34 1.21e-10 Blood metabolite levels; CRC trans rs12599106 0.560 rs34151874 chr16:34989694 G/A cg05064044 chr6:292385 DUSP22 -0.74 -10.54 -0.5 1.42e-22 Menopause (age at onset); CRC cis rs2074585 0.647 rs2601188 chr15:90929563 A/G cg22089800 chr15:90895588 ZNF774 -0.57 -9.44 -0.46 6.97e-19 Basophil percentage of granulocytes;White blood cell count (basophil);Basophil percentage of white cells; CRC cis rs2243480 1.000 rs778691 chr7:65873092 G/C cg12463550 chr7:65579703 CRCP 0.7 6.26 0.33 1.22e-9 Diabetic kidney disease; CRC cis rs2019137 0.560 rs10175462 chr2:113988492 G/A cg25243455 chr2:114033360 PAX8;LOC440839 -0.28 -6.92 -0.36 2.41e-11 Lymphocyte counts; CRC cis rs7274811 0.625 rs293723 chr20:31927706 A/G cg07470512 chr20:32255052 NECAB3;C20orf134 -0.43 -5.81 -0.3 1.49e-8 Height; CRC cis rs8105895 0.935 rs2043319 chr19:22274595 A/G cg02657401 chr19:22469223 NA -0.35 -5.6 -0.3 4.44e-8 Body mass index (change over time); CRC cis rs873946 0.586 rs36084869 chr10:134566069 G/A cg27286337 chr10:134555280 INPP5A 0.82 9.97 0.48 1.25e-20 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CRC cis rs344364 0.511 rs1742468 chr16:1950243 C/G cg03013636 chr16:1946785 NA 0.58 7.08 0.36 8.69e-12 Glomerular filtration rate in chronic kidney disease; CRC cis rs12580194 0.593 rs4448777 chr12:55724981 T/C cg19537932 chr12:55886519 OR6C68 -0.7 -8.73 -0.43 1.31e-16 Cancer; CRC cis rs9733 0.519 rs1336900 chr1:150679033 C/T cg10589385 chr1:150898437 SETDB1 0.28 6.05 0.32 4.05e-9 Tonsillectomy; CRC cis rs8072100 0.575 rs1221385 chr17:45527574 T/G cg08085267 chr17:45401833 C17orf57 -0.51 -7.27 -0.37 2.63e-12 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs72781680 0.898 rs56413706 chr2:24086961 G/A cg08917208 chr2:24149416 ATAD2B 1.02 9.92 0.48 1.78e-20 Lymphocyte counts; CRC cis rs4969178 0.965 rs8077859 chr17:76386335 C/T cg20026190 chr17:76395443 PGS1 0.38 5.92 0.31 8.06e-9 HDL cholesterol levels; CRC cis rs1322512 0.959 rs2758798 chr6:152943980 A/G cg03415253 chr6:152958462 SYNE1 -0.41 -6.38 -0.33 6.06e-10 Tonometry; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg24594295 chr1:151966792 S100A10 0.41 6.02 0.31 4.75e-9 Intelligence (multi-trait analysis); CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg23181591 chr8:123793873 ZHX2 -0.5 -5.99 -0.31 5.52e-9 Diisocyanate-induced asthma; CRC cis rs2727020 0.590 rs7949936 chr11:49378902 G/A cg27395922 chr11:50257633 LOC441601 -0.37 -5.69 -0.3 2.87e-8 Coronary artery disease; CRC cis rs4654899 0.758 rs6668370 chr1:21369568 C/T cg02927042 chr1:21476669 EIF4G3 -0.39 -6.15 -0.32 2.24e-9 Superior frontal gyrus grey matter volume; CRC cis rs736408 0.634 rs11717836 chr3:52807736 A/G cg15147215 chr3:52552868 STAB1 -0.62 -10.0 -0.48 9.6e-21 Bipolar disorder; CRC cis rs9399135 0.967 rs6925424 chr6:135313948 T/A cg22676075 chr6:135203613 NA 0.42 6.51 0.34 2.78e-10 Red blood cell count; CRC cis rs853679 0.517 rs12332979 chr6:28141548 T/G cg12172441 chr6:28176163 NA 0.63 7.43 0.38 9.41e-13 Depression; CRC cis rs7259376 0.902 rs11669270 chr19:22604816 G/A cg02657401 chr19:22469223 NA 0.3 6.54 0.34 2.3e-10 Menopause (age at onset); CRC cis rs2076222 1.000 rs2076350 chr1:209800341 C/T cg00257659 chr1:209800214 LAMB3 -1.06 -10.11 -0.49 4.16e-21 Fentanyl consumption in laparoscopic-assisted colectomy (first 24 hours); CRC cis rs10504229 0.683 rs903702 chr8:58128557 T/C cg21724239 chr8:58056113 NA 0.49 6.81 0.35 4.75e-11 Developmental language disorder (linguistic errors); CRC cis rs172166 0.637 rs1233708 chr6:28173219 C/T cg23161317 chr6:28129485 ZNF389 0.42 6.02 0.32 4.55e-9 Cardiac Troponin-T levels; CRC cis rs4713118 0.696 rs2394002 chr6:27748015 G/A cg12172441 chr6:28176163 NA 0.54 6.99 0.36 1.49e-11 Parkinson's disease; CRC cis rs4731207 0.596 rs1481327 chr7:124628282 G/A cg23710748 chr7:124431027 NA -0.4 -6.33 -0.33 7.94e-10 Cutaneous malignant melanoma; CRC cis rs10504229 0.683 rs56208052 chr8:58130207 A/T cg02290350 chr8:58132656 NA -0.58 -8.16 -0.41 7.29e-15 Developmental language disorder (linguistic errors); CRC cis rs910316 0.763 rs175490 chr14:75545685 A/G cg03030879 chr14:75389066 RPS6KL1 -0.4 -6.13 -0.32 2.57e-9 Height; CRC cis rs7113874 0.610 rs1446462 chr11:8566343 C/T cg20771178 chr11:8615675 STK33 -0.36 -5.89 -0.31 9.43e-9 Body mass index in physically active individuals;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs7089973 0.966 rs36089581 chr10:116623059 G/C cg23260525 chr10:116636907 FAM160B1 0.31 5.97 0.31 6.17e-9 Bipolar disorder or attention deficit hyperactivity disorder; CRC cis rs4819052 0.807 rs4819047 chr21:46665139 C/T cg19498844 chr21:46707878 POFUT2;LOC642852 0.78 11.23 0.53 5.36e-25 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs2806561 0.894 rs629107 chr1:23537971 C/T cg19743168 chr1:23544995 NA 0.38 6.0 0.31 5.25e-9 Height; CRC cis rs9368481 0.761 rs7775041 chr6:27009512 T/A cg18278486 chr6:26987575 LOC100270746;C6orf41 -0.45 -7.06 -0.36 9.9e-12 Autism spectrum disorder or schizophrenia; CRC cis rs7739232 0.920 rs78684814 chr6:53527508 T/C cg15658676 chr6:53530538 KLHL31 -0.76 -5.9 -0.31 8.9e-9 Hip circumference adjusted for BMI; CRC trans rs2303319 0.504 rs12470830 chr2:162429996 C/T cg18122310 chr12:50236657 BCDIN3D -0.75 -6.2 -0.32 1.68e-9 Cognitive function; CRC cis rs425277 0.606 rs451061 chr1:2075068 C/G cg03732007 chr1:2071316 PRKCZ 0.35 5.68 0.3 3.01e-8 Height; CRC cis rs753778 0.667 rs10092439 chr8:142210881 C/T cg18755752 chr8:142205143 DENND3 -0.67 -11.75 -0.54 7.56e-27 Reticulocyte fraction of red cells;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; CRC cis rs7618501 0.573 rs7634917 chr3:50049299 T/G cg24308560 chr3:49941425 MST1R 0.51 8.19 0.41 5.85e-15 Intelligence (multi-trait analysis); CRC cis rs1448094 0.511 rs10863080 chr12:86153149 C/T cg18827107 chr12:86230957 RASSF9 0.39 5.98 0.31 5.76e-9 Major depressive disorder; CRC cis rs311392 0.902 rs419813 chr8:55092385 A/T cg20636351 chr8:55087400 NA -0.33 -5.96 -0.31 6.62e-9 Pelvic organ prolapse (moderate/severe); CRC cis rs6988985 0.678 rs1799998 chr8:143999600 A/G cg10324643 chr8:143916377 GML 0.39 6.54 0.34 2.34e-10 Plasma androstenedione levels in resected early stage-receptor positive breast cancer; CRC cis rs17384381 0.953 rs12138621 chr1:85783970 T/C cg16011679 chr1:85725395 C1orf52 0.67 6.87 0.35 3.17e-11 Lobe attachment (rater-scored or self-reported); CRC cis rs9322193 0.923 rs3924871 chr6:149983216 G/A cg07701084 chr6:150067640 NUP43 0.56 8.2 0.41 5.45e-15 Lung cancer; CRC cis rs273218 0.573 rs11742692 chr5:53343576 C/T cg22592108 chr5:53304441 ARL15 0.48 6.0 0.31 5.23e-9 Migraine; CRC cis rs72799341 1.000 rs7200879 chr16:30947572 A/G cg02466173 chr16:30829666 NA -0.73 -8.96 -0.44 2.48e-17 Diastolic blood pressure; CRC cis rs62064224 0.902 rs35830939 chr17:30627564 A/C cg09324608 chr17:30823087 MYO1D 0.4 6.75 0.35 6.5500000000000006e-11 Schizophrenia; CRC cis rs853679 1.000 rs735765 chr6:28170297 G/A cg12172441 chr6:28176163 NA 0.65 6.23 0.32 1.45e-9 Depression; CRC trans rs57221529 0.766 rs1399381 chr5:589853 G/T cg11887960 chr12:57824829 NA 0.63 6.89 0.36 2.93e-11 Lung disease severity in cystic fibrosis; CRC cis rs13161895 0.591 rs12655422 chr5:179480825 C/A cg02702477 chr5:179499311 RNF130 0.64 7.06 0.36 9.81e-12 LDL cholesterol; CRC cis rs7927771 0.524 rs7124396 chr11:47787434 T/G cg20307385 chr11:47447363 PSMC3 -0.45 -6.64 -0.34 1.28e-10 Subjective well-being; CRC cis rs6998277 1.000 rs62523306 chr8:103640752 C/A cg10187029 chr8:103597600 NA 0.93 11.85 0.55 3.31e-27 Migraine; CRC cis rs741668 0.931 rs61953332 chr13:46590274 G/C cg06018095 chr13:46550134 ZC3H13 0.41 5.75 0.3 2.01e-8 Cerebrospinal fluid clusterin levels; CRC cis rs7904368 0.754 rs7076955 chr10:16852781 G/A cg14835575 chr10:16859367 RSU1 0.49 6.69 0.35 9.46e-11 Ratio of the peak velocity of the mitral E-Wave divided by the peak velocity of the mitral A-wave.; CRC cis rs7493 0.950 rs56265549 chr7:95047155 G/A cg17330251 chr7:94953956 PON1 -0.56 -7.25 -0.37 3.02e-12 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs798554 0.610 rs2251491 chr7:2852835 T/C cg13628971 chr7:2884303 GNA12 0.43 6.81 0.35 4.57e-11 Height; CRC cis rs8010715 0.816 rs6573573 chr14:24599257 T/C cg23112188 chr14:24563095 PCK2 -0.36 -7.23 -0.37 3.41e-12 IgG glycosylation; CRC cis rs1975974 0.574 rs17052370 chr17:21736353 A/G cg18423549 chr17:21743878 NA 0.67 10.01 0.48 9.03e-21 Psoriasis; CRC cis rs9487051 0.676 rs9400268 chr6:109600550 C/T cg01475377 chr6:109611718 NA -0.36 -6.45 -0.34 3.95e-10 Reticulocyte fraction of red cells; CRC cis rs4727027 0.933 rs10277119 chr7:148849942 T/C cg23583168 chr7:148888333 NA -0.89 -15.12 -0.64 1.43e-39 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC cis rs9894429 0.789 rs6565611 chr17:79598319 T/C cg21028142 chr17:79581711 NPLOC4 0.32 6.86 0.35 3.43e-11 Eye color traits; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg00866667 chr19:40031046 EID2 0.44 5.97 0.31 6.05e-9 Response to antipsychotic treatment; CRC cis rs10883723 0.847 rs3808934 chr10:104264280 C/T cg11453585 chr10:104263688 ACTR1A;SUFU 0.92 17.58 0.7 2.89e-49 Allergic disease (asthma, hay fever or eczema); CRC cis rs1018836 0.923 rs1858674 chr8:91580665 G/T cg16814680 chr8:91681699 NA -0.72 -11.42 -0.53 1.15e-25 Ejection fraction in Tripanosoma cruzi seropositivity; CRC cis rs8180040 0.654 rs6773521 chr3:47234419 A/G cg10298567 chr3:47292165 KIF9 0.4 6.28 0.33 1.08e-9 Colorectal cancer; CRC cis rs2033711 0.840 rs3764533 chr19:58929194 A/G cg26874164 chr19:58962979 ZNF324B 0.4 5.61 0.3 4.27e-8 Uric acid clearance; CRC cis rs1707322 0.896 rs809774 chr1:46560244 T/A cg06784218 chr1:46089804 CCDC17 -0.56 -9.76 -0.47 6.48e-20 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs11148252 0.538 rs9535887 chr13:52730761 G/A cg02158880 chr13:53174818 NA 0.42 6.06 0.32 3.63e-9 Lewy body disease; CRC cis rs1348850 0.567 rs3770011 chr2:178537890 C/T cg02961200 chr2:178257176 LOC100130691;AGPS 0.54 7.47 0.38 7.49e-13 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC trans rs2797160 1.000 rs1739380 chr6:126012858 T/C cg05039488 chr6:79577232 IRAK1BP1 0.51 7.58 0.39 3.52e-13 Endometrial cancer; CRC cis rs10504229 0.728 rs17215753 chr8:58153764 A/G cg22535103 chr8:58192502 C8orf71 -0.68 -8.37 -0.42 1.72e-15 Developmental language disorder (linguistic errors); CRC cis rs4665809 1.000 rs12475854 chr2:26267375 G/A cg04944784 chr2:26401820 FAM59B -0.58 -7.52 -0.38 5.39e-13 Gut microbiome composition (summer); CRC cis rs10751667 0.666 rs7395402 chr11:950293 A/G cg01483505 chr11:975446 AP2A2 -0.44 -7.29 -0.37 2.31e-12 Alzheimer's disease (late onset); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg03262694 chr11:64684810 ATG2A 0.48 6.84 0.35 3.93e-11 Response to antipsychotic treatment; CRC trans rs1814175 0.617 rs6486020 chr11:49769149 T/G cg11707556 chr5:10655725 ANKRD33B -0.51 -9.76 -0.47 6.37e-20 Height; CRC cis rs7737355 0.812 rs9687376 chr5:130918037 A/C cg25547332 chr5:131281432 NA 0.38 5.93 0.31 7.75e-9 Life satisfaction; CRC cis rs4889855 0.505 rs6565467 chr17:78610113 A/G cg16591659 chr17:78472290 NA -0.45 -6.72 -0.35 8.05e-11 Fractional excretion of uric acid; CRC cis rs4481887 1.000 rs10788781 chr1:248494262 C/T cg13385794 chr1:248469461 NA 0.39 6.65 0.34 1.23e-10 Common traits (Other); CRC cis rs7580658 0.963 rs6732279 chr2:128089540 G/T cg09760422 chr2:128146352 NA -0.36 -6.93 -0.36 2.27e-11 Protein C levels; CRC cis rs1707322 0.752 rs4586014 chr1:46150443 A/G cg03146154 chr1:46216737 IPP 0.67 9.71 0.47 8.93e-20 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs4363385 0.667 rs78426057 chr1:152964528 T/C cg25856811 chr1:152973957 SPRR3 -0.26 -7.18 -0.37 4.82e-12 Inflammatory skin disease; CRC cis rs9420 0.961 rs7121169 chr11:57452543 G/A cg23127183 chr11:57508653 C11orf31 -0.52 -7.04 -0.36 1.12e-11 Schizophrenia; CRC cis rs941873 0.805 rs10762860 chr10:81117794 C/G cg09469691 chr10:81107165 PPIF 0.53 8.27 0.42 3.26e-15 Height; CRC trans rs11098499 0.909 rs28555550 chr4:120211040 C/G cg25214090 chr10:38739885 LOC399744 0.52 7.88 0.4 4.94e-14 Corneal astigmatism; CRC cis rs727505 1.000 rs727505 chr7:124462081 C/T cg14311320 chr7:124405732 GPR37 -0.37 -5.61 -0.3 4.3e-8 Lewy body disease; CRC cis rs7727544 0.507 rs11741341 chr5:131570218 A/G cg22638593 chr5:131593259 PDLIM4 0.48 8.84 0.44 5.99e-17 Blood metabolite levels; CRC cis rs5750830 0.649 rs5750820 chr22:39825322 T/G cg24399712 chr22:39784796 NA -0.51 -10.18 -0.49 2.38e-21 Intelligence (multi-trait analysis); CRC cis rs1552244 0.938 rs34750074 chr3:10091740 G/A cg08888203 chr3:10149979 C3orf24 0.72 9.97 0.48 1.26e-20 Alzheimer's disease; CRC cis rs10256972 0.721 rs2030959 chr7:1075906 T/C cg18402987 chr7:1209562 NA 0.41 6.16 0.32 2.16e-9 Longevity;Endometriosis; CRC cis rs2777491 1.000 rs2777491 chr15:41735710 T/G cg18705301 chr15:41695430 NDUFAF1 -0.74 -12.68 -0.57 2.79e-30 Ulcerative colitis; CRC cis rs11122272 0.735 rs2486730 chr1:231534987 T/G cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.58 -8.64 -0.43 2.42e-16 Hemoglobin concentration; CRC cis rs7538876 0.903 rs7528427 chr1:17746273 C/T cg07965774 chr1:17746286 RCC2 0.32 6.15 0.32 2.22e-9 Basal cell carcinoma; CRC cis rs6502050 0.626 rs11868521 chr17:80100195 T/G cg22110888 chr17:80059540 CCDC57 -0.43 -6.55 -0.34 2.27e-10 Life satisfaction; CRC cis rs11628318 0.515 rs11850580 chr14:103156586 C/T cg12046867 chr14:103022105 NA 0.4 5.62 0.3 3.99e-8 Platelet count; CRC cis rs6502050 0.835 rs8080423 chr17:80102279 A/G cg22110888 chr17:80059540 CCDC57 0.4 6.44 0.33 4.17e-10 Life satisfaction; CRC cis rs72781680 1.000 rs72781683 chr2:24247423 T/C cg08917208 chr2:24149416 ATAD2B 0.96 8.78 0.44 9.31e-17 Lymphocyte counts; CRC cis rs7811142 0.943 rs111757992 chr7:100016354 A/C cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.05 15.27 0.64 3.72e-40 Platelet count; CRC cis rs9611565 0.659 rs17367849 chr22:41923644 G/A cg03806693 chr22:41940476 POLR3H -1.14 -15.23 -0.64 5.13e-40 Vitiligo; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg10884662 chr15:75871802 PTPN9 0.42 6.97 0.36 1.73e-11 Liver disease severity in Alagille syndrome; CRC cis rs9768139 0.708 rs921616 chr7:158117960 A/G cg25566285 chr7:158114605 PTPRN2 0.47 7.5 0.38 6.01e-13 Calcium levels; CRC cis rs2530545 0.762 rs17169924 chr7:34667565 G/T cg14401837 chr7:34697493 NPSR1 0.43 6.34 0.33 7.68e-10 IgG glycosylation; CRC cis rs2976388 1.000 rs1045574 chr8:143763958 C/T cg04969067 chr8:143858791 LYNX1 -0.34 -5.84 -0.31 1.28e-8 Urinary tract infection frequency; CRC cis rs992157 0.764 rs2015863 chr2:219185161 C/T cg04731861 chr2:219085781 ARPC2 0.3 5.72 0.3 2.41e-8 Colorectal cancer; CRC cis rs970548 0.954 rs10466245 chr10:46031747 G/A cg15590007 chr10:45870220 ALOX5 0.48 6.17 0.32 2.04e-9 Total cholesterol levels;Cholesterol, total;HDL cholesterol;HDL cholesterol levels; CRC cis rs2456568 0.867 rs2462744 chr11:93682913 G/A cg26875233 chr11:93583750 C11orf90 -0.34 -6.71 -0.35 8.58e-11 Response to serotonin reuptake inhibitors in major depressive disorder; CRC cis rs3806843 0.712 rs2530244 chr5:140109155 A/G cg19875535 chr5:140030758 IK -0.55 -8.89 -0.44 4.23e-17 Depressive symptoms (multi-trait analysis); CRC cis rs1059312 0.808 rs900982 chr12:129304369 G/A cg23521905 chr12:129298690 SLC15A4;MGC16384 0.36 6.2 0.32 1.66e-9 Systemic lupus erythematosus; CRC cis rs7945705 0.902 rs7930026 chr11:9013639 T/C cg00186954 chr11:8933980 ST5;C11orf17 0.42 6.48 0.34 3.41e-10 Hemoglobin concentration; CRC cis rs7428796 0.507 rs11127935 chr3:86364123 C/T cg11326485 chr3:87275983 CHMP2B -0.38 -5.73 -0.3 2.26e-8 Myopia (pathological); CRC cis rs9311474 0.508 rs7614498 chr3:52618941 A/T cg05573699 chr3:52720067 GNL3;PBRM1 -0.46 -6.77 -0.35 5.8200000000000003e-11 Electroencephalogram traits; CRC cis rs7216064 0.953 rs58141639 chr17:65864902 C/T cg12091567 chr17:66097778 LOC651250 -0.68 -7.87 -0.4 5.31e-14 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CRC cis rs875971 0.540 rs781152 chr7:65479572 T/A cg18876405 chr7:65276391 NA 0.67 11.75 0.54 7.17e-27 Aortic root size; CRC cis rs7085104 0.700 rs10786712 chr10:104596396 A/G cg04362960 chr10:104952993 NT5C2 -0.6 -9.07 -0.45 1.13e-17 Immature fraction of reticulocytes;Schizophrenia; CRC cis rs523522 0.923 rs10774553 chr12:120954984 T/C cg27279351 chr12:120934652 DYNLL1 0.78 11.48 0.53 7.05e-26 High light scatter reticulocyte count; CRC cis rs6951245 0.938 rs11764937 chr7:1092074 C/T cg20603222 chr7:1096387 C7orf50;GPR146 -0.72 -8.72 -0.43 1.41e-16 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs703842 1.000 rs11172343 chr12:58188157 T/C cg00677455 chr12:58241039 CTDSP2 0.64 8.66 0.43 2.14e-16 Multiple sclerosis; CRC trans rs11165623 0.792 rs12123543 chr1:96964549 T/C cg10631902 chr5:14652156 NA -0.49 -9.14 -0.45 6.73e-18 Hip circumference;Waist circumference; CRC cis rs524281 0.861 rs7937281 chr11:65950074 T/C cg16950941 chr11:66035639 RAB1B -0.57 -7.14 -0.37 5.84e-12 Electroencephalogram traits; CRC cis rs644799 0.509 rs561635 chr11:95634232 C/T cg25622487 chr11:95524042 FAM76B;CEP57 -0.48 -7.03 -0.36 1.16e-11 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs11252926 0.604 rs2050970 chr10:515870 C/T cg03684893 chr10:554711 DIP2C -0.36 -6.34 -0.33 7.58e-10 Psychosis in Alzheimer's disease; CRC cis rs10791323 0.592 rs2851115 chr11:133705381 C/A cg00579200 chr11:133705235 NA -0.41 -5.93 -0.31 7.52e-9 Childhood ear infection; CRC cis rs3796352 1.000 rs33999310 chr3:52883332 G/A cg27565382 chr3:53032988 SFMBT1 0.75 6.04 0.32 4.11e-9 Immune reponse to smallpox (secreted IL-2); CRC cis rs789859 0.869 rs1773225 chr3:194403578 A/G cg21106136 chr3:194405973 FAM43A -0.5 -7.49 -0.38 6.53e-13 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; CRC cis rs7772486 0.701 rs2244308 chr6:146213706 C/T cg13319975 chr6:146136371 FBXO30 -0.4 -5.99 -0.31 5.54e-9 Lobe attachment (rater-scored or self-reported); CRC trans rs7618501 0.633 rs11925192 chr3:50038664 G/A cg21665057 chr3:196295764 WDR53;FBXO45 0.52 8.09 0.41 1.15e-14 Intelligence (multi-trait analysis); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg16800975 chr8:17434541 PDGFRL 0.51 8.27 0.41 3.25e-15 Liver disease severity in Alagille syndrome; CRC cis rs75422866 0.867 rs73104155 chr12:48094573 T/C cg14736327 chr12:48174669 SLC48A1 -0.79 -6.01 -0.31 4.92e-9 Pneumonia; CRC cis rs2404602 0.735 rs11857015 chr15:76649390 T/C cg23625390 chr15:77176239 SCAPER -0.84 -13.13 -0.59 5.94e-32 Blood metabolite levels; CRC cis rs56235845 0.694 rs4532376 chr5:176774403 G/A cg05207973 chr5:176823642 SLC34A1 0.35 5.94 0.31 7.08e-9 Hemoglobin concentration;Hematocrit; CRC cis rs77956314 0.515 rs4238051 chr12:117366299 A/G cg02017074 chr12:117425053 FBXW8 0.66 8.26 0.41 3.7e-15 Subcortical brain region volumes;Hippocampal volume; CRC trans rs11098499 0.866 rs12499602 chr4:120284387 T/A cg25214090 chr10:38739885 LOC399744 0.61 9.66 0.47 1.39e-19 Corneal astigmatism; CRC cis rs1552244 0.554 rs2272118 chr3:10049287 T/C cg13047869 chr3:10149882 C3orf24 0.39 5.95 0.31 6.8e-9 Alzheimer's disease; CRC cis rs713587 0.525 rs11675457 chr2:25079770 C/T cg22495460 chr2:25135724 ADCY3 -0.84 -15.95 -0.66 7.89e-43 Body mass index in non-asthmatics; CRC cis rs7659604 0.539 rs3217773 chr4:122739121 A/G cg23574427 chr4:122746245 BBS7;CCNA2 -0.3 -5.7 -0.3 2.61e-8 Type 2 diabetes; CRC cis rs11864453 0.762 rs6416742 chr16:72149061 C/T cg23815491 chr16:72088622 HP 0.64 9.75 0.47 6.66e-20 Fibrinogen levels; CRC trans rs11026407 0.967 rs7127246 chr11:22060228 C/G cg19958696 chr11:107992251 ACAT1 -0.55 -6.0 -0.31 5.16e-9 Plasma thyroid-stimulating hormone levels; CRC cis rs13108904 0.870 rs4974545 chr4:1271923 C/T cg16405210 chr4:1374714 KIAA1530 -0.42 -5.73 -0.3 2.27e-8 Obesity-related traits; CRC cis rs3806843 0.966 rs2240693 chr5:140183325 G/C cg19875535 chr5:140030758 IK 0.63 10.19 0.49 2.25e-21 Depressive symptoms (multi-trait analysis); CRC cis rs7811142 0.887 rs35111986 chr7:100000274 C/A cg00814883 chr7:100076585 TSC22D4 -0.78 -9.66 -0.47 1.3e-19 Platelet count; CRC cis rs9549328 0.670 rs61963562 chr13:113616523 T/G cg08614441 chr13:113633676 MCF2L 0.4 6.97 0.36 1.69e-11 Systolic blood pressure; CRC cis rs1129187 0.967 rs6941212 chr6:42915920 A/G cg26304593 chr6:42947056 PEX6 -0.41 -5.84 -0.31 1.23e-8 Alzheimer's disease in APOE e4+ carriers; CRC cis rs6748734 1.000 rs6724662 chr2:241831560 A/G cg04034577 chr2:241836375 C2orf54 -0.42 -8.83 -0.44 6.51e-17 Urinary metabolites; CRC cis rs10484885 0.571 rs76955220 chr6:90252030 A/G cg13799429 chr6:90582589 CASP8AP2 -0.56 -6.32 -0.33 8.43e-10 QRS interval (sulfonylurea treatment interaction); CRC trans rs1455244 0.700 rs7229302 chr18:11508904 G/T cg00108277 chr3:49840710 C3orf54 0.42 6.72 0.35 8.2e-11 Schizophrenia; CRC cis rs4363385 0.747 rs4240867 chr1:152954921 A/G cg25856811 chr1:152973957 SPRR3 0.25 7.01 0.36 1.38e-11 Inflammatory skin disease; CRC trans rs9929218 0.953 rs16260 chr16:68771034 C/A cg04657470 chr2:198365150 HSPE1;HSPD1 -0.96 -14.39 -0.62 9.71e-37 Colorectal cancer; CRC cis rs79349575 0.749 rs58838744 chr17:46998902 A/G cg22482690 chr17:47019901 SNF8 0.48 8.07 0.41 1.33e-14 Type 2 diabetes; CRC cis rs7586879 0.828 rs13428789 chr2:25087643 C/T cg04586622 chr2:25135609 ADCY3 -0.5 -8.4 -0.42 1.39e-15 Body mass index; CRC cis rs2342406 0.825 rs1026061 chr2:45142011 C/G cg23424933 chr2:45157613 NA 0.43 5.71 0.3 2.57e-8 Myopia; CRC cis rs9309473 0.607 rs1403412 chr2:73598092 T/C cg20560298 chr2:73613845 ALMS1 -0.49 -6.8 -0.35 4.84e-11 Metabolite levels; CRC cis rs7731657 0.537 rs4705976 chr5:130286160 T/C cg08523029 chr5:130500466 HINT1 0.43 5.69 0.3 2.74e-8 Fasting plasma glucose; CRC cis rs523522 0.962 rs4767902 chr12:120910004 C/T cg12219531 chr12:120966889 COQ5 0.71 9.34 0.46 1.55e-18 High light scatter reticulocyte count; CRC cis rs7937682 1.000 rs11213980 chr11:111562692 A/T cg09085632 chr11:111637200 PPP2R1B 1.02 18.92 0.72 1.55e-54 Primary sclerosing cholangitis; CRC cis rs6540559 0.673 rs6540561 chr1:209982255 C/T cg23283495 chr1:209979779 IRF6 0.46 6.63 0.34 1.4e-10 Cleft lip with or without cleft palate; CRC cis rs4731207 0.698 rs11978628 chr7:124449897 C/T cg23710748 chr7:124431027 NA 0.37 5.96 0.31 6.53e-9 Cutaneous malignant melanoma; CRC cis rs12681288 0.792 rs12678495 chr8:1000858 C/G cg04851639 chr8:1020857 NA -0.31 -6.64 -0.34 1.33e-10 Schizophrenia; CRC cis rs4654899 0.931 rs3767241 chr1:21166144 C/T cg02927042 chr1:21476669 EIF4G3 0.41 6.55 0.34 2.24e-10 Superior frontal gyrus grey matter volume; CRC cis rs9322193 0.962 rs3805749 chr6:150093682 C/T cg05861140 chr6:150128134 PCMT1 -0.4 -6.12 -0.32 2.59e-9 Lung cancer; CRC cis rs514406 0.667 rs10788942 chr1:53210521 A/T cg24675658 chr1:53192096 ZYG11B 0.71 11.66 0.54 1.53e-26 Monocyte count; CRC cis rs4964805 0.773 rs4964623 chr12:104222742 G/A cg02344784 chr12:104178138 NT5DC3 0.48 6.66 0.34 1.18e-10 Attention deficit hyperactivity disorder; CRC cis rs9916302 0.706 rs439537 chr17:37734482 T/C cg07936489 chr17:37558343 FBXL20 -0.93 -11.32 -0.53 2.62e-25 Glomerular filtration rate (creatinine); CRC trans rs208520 0.690 rs12189780 chr6:66759619 G/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 1.04 14.58 0.63 1.79e-37 Exhaled nitric oxide output; CRC cis rs11112613 0.713 rs73184081 chr12:105951745 C/T cg03607813 chr12:105948248 NA 0.77 10.67 0.51 5.19e-23 Corrected insulin response;Corrected insulin response adjusted for insulin sensitivity index; CRC cis rs523522 0.962 rs3893104 chr12:120903936 G/A cg12219531 chr12:120966889 COQ5 0.71 9.34 0.46 1.55e-18 High light scatter reticulocyte count; CRC cis rs3858526 0.584 rs10742809 chr11:5862532 G/T cg13902645 chr11:5959945 NA 0.62 8.85 0.44 5.57e-17 DNA methylation (variation); CRC cis rs2885135 0.559 rs1148455 chr1:13914230 A/G cg04886857 chr1:13914270 PDPN 0.31 6.11 0.32 2.83e-9 Response to cytadine analogues (cytosine arabinoside); CRC trans rs11148252 0.774 rs56033750 chr13:52747278 A/C cg18335740 chr13:41363409 SLC25A15 0.56 9.03 0.45 1.5e-17 Lewy body disease; CRC cis rs7223966 1.000 rs11654335 chr17:61797579 A/T cg05941027 chr17:61774174 LIMD2 0.36 6.47 0.34 3.52e-10 Hip circumference adjusted for BMI;Body mass index; CRC cis rs6500602 0.701 rs8053770 chr16:4539030 T/A cg06139259 chr16:4526053 HMOX2;NMRAL1 0.5 6.8 0.35 5.08e-11 Schizophrenia; CRC cis rs9549328 0.611 rs72661939 chr13:113617498 C/T cg17524180 chr13:113633600 MCF2L 0.52 9.5 0.46 4.44e-19 Systolic blood pressure; CRC cis rs1983891 0.874 rs3747744 chr6:41516351 A/G cg20194872 chr6:41519635 FOXP4 0.41 5.98 0.31 5.72e-9 Prostate cancer; CRC cis rs1997103 1.000 rs10249105 chr7:55412405 A/G cg17469321 chr7:55412551 NA -0.7 -11.3 -0.53 2.99e-25 QRS interval (sulfonylurea treatment interaction); CRC cis rs2075371 1.000 rs2598297 chr7:133993001 T/G cg02659138 chr7:134003124 SLC35B4 0.4 6.82 0.35 4.25e-11 Mean platelet volume; CRC cis rs6840360 0.582 rs7691601 chr4:152321631 A/G cg09659197 chr4:152720779 NA 0.3 5.66 0.3 3.28e-8 Intelligence (multi-trait analysis); CRC trans rs1814175 0.645 rs7115592 chr11:50013243 A/G cg15704280 chr7:45808275 SEPT13 -0.92 -16.92 -0.68 1.2e-46 Height; CRC cis rs9297145 0.565 rs7794690 chr7:98764768 G/A cg05967295 chr7:98741636 SMURF1 -0.66 -10.56 -0.5 1.2e-22 Crohn's disease;Inflammatory bowel disease;Ulcerative colitis; CRC cis rs9611565 0.694 rs202617 chr22:41822793 C/T cg03806693 chr22:41940476 POLR3H 1.06 13.2 0.59 3.23e-32 Vitiligo; CRC cis rs6793245 0.810 rs9843500 chr3:38588095 G/C cg01465620 chr3:38496096 LOC100128640;ACVR2B -0.57 -8.48 -0.42 7.65e-16 QT interval; CRC cis rs28386778 0.897 rs2665844 chr17:61874455 A/G cg22520471 chr17:61851767 DDX42;CCDC47 0.75 11.65 0.54 1.65e-26 Prudent dietary pattern; CRC trans rs1455244 0.700 rs7229302 chr18:11508904 G/T cg16478012 chr16:87425779 FBXO31;MAP1LC3B 0.38 6.11 0.32 2.82e-9 Schizophrenia; CRC cis rs763121 0.853 rs138713 chr22:39142615 T/C cg06022373 chr22:39101656 GTPBP1 0.77 11.5 0.54 6.07e-26 Menopause (age at onset); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg20749283 chr15:69755176 NA 0.39 6.27 0.33 1.12e-9 Liver disease severity in Alagille syndrome; CRC cis rs6062302 0.522 rs2236503 chr20:62224595 G/A cg16989086 chr20:62203971 PRIC285 0.47 6.03 0.32 4.52e-9 Glioblastoma; CRC cis rs8014204 0.836 rs7153700 chr14:75268544 C/T cg03030879 chr14:75389066 RPS6KL1 -0.49 -7.8 -0.4 8.08e-14 Caffeine consumption; CRC cis rs7811142 0.830 rs76798830 chr7:99952828 C/T cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.94 11.97 0.55 1.17e-27 Platelet count; CRC cis rs72717009 0.825 rs6671753 chr1:161478708 G/A cg10431340 chr1:161279108 MPZ -0.52 -6.96 -0.36 1.84e-11 Rheumatoid arthritis; CRC cis rs2795502 1.000 rs2473119 chr10:43339038 A/T cg20628663 chr10:43360327 NA -0.69 -10.63 -0.51 7.04e-23 Blood protein levels; CRC cis rs1670533 1.000 rs651017 chr4:1091062 A/G cg27284194 chr4:1044797 NA 0.43 5.78 0.3 1.73e-8 Recombination rate (females); CRC cis rs11212617 0.967 rs227074 chr11:108215095 A/G cg12106634 chr11:108092400 ATM;NPAT 0.43 6.35 0.33 7.28e-10 Response to metformin in type 2 diabetes (glycemic); CRC cis rs4589502 0.502 rs2169460 chr15:67197240 A/G cg18595228 chr15:67193261 NA -0.46 -6.6 -0.34 1.68e-10 Lung cancer (smoking interaction); CRC trans rs7618501 0.633 rs7628058 chr3:50039474 C/T cg21665057 chr3:196295764 WDR53;FBXO45 0.59 9.39 0.46 1.04e-18 Intelligence (multi-trait analysis); CRC cis rs7647973 0.580 rs7652746 chr3:49262307 C/T cg07636037 chr3:49044803 WDR6 -0.8 -12.35 -0.56 4.75e-29 Menarche (age at onset); CRC cis rs123509 0.913 rs339682 chr3:42791123 A/G cg12982090 chr3:42733453 KBTBD5 0.54 7.05 0.36 1.07e-11 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs853679 0.517 rs34716816 chr6:28046169 C/A cg12273811 chr6:28175739 NA 0.69 8.83 0.44 6.17e-17 Depression; CRC cis rs4919694 1.000 rs17727391 chr10:104836101 C/A cg04362960 chr10:104952993 NT5C2 1.12 10.16 0.49 2.88e-21 Arsenic metabolism; CRC cis rs13108904 0.905 rs11247983 chr4:1281951 C/G cg21620606 chr4:1342894 KIAA1530 0.35 5.76 0.3 1.9e-8 Obesity-related traits; CRC cis rs898097 0.841 rs12453162 chr17:80859971 C/T cg15664640 chr17:80829946 TBCD -0.69 -11.47 -0.53 7.63e-26 Breast cancer; CRC cis rs7412746 0.658 rs2089082 chr1:150800090 T/G cg18016565 chr1:150552671 MCL1 0.44 6.19 0.32 1.8e-9 Melanoma; CRC cis rs9467711 0.559 rs9393727 chr6:26500011 C/G cg12315302 chr6:26189340 HIST1H4D 0.75 6.33 0.33 7.88e-10 Autism spectrum disorder or schizophrenia; CRC cis rs3858526 0.584 rs10769270 chr11:5860563 T/C cg13902645 chr11:5959945 NA -0.66 -9.18 -0.45 4.99e-18 DNA methylation (variation); CRC cis rs12291225 0.679 rs10832240 chr11:14304744 C/T cg05501817 chr11:14380813 RRAS2 -0.46 -6.06 -0.32 3.7e-9 Sense of smell; CRC cis rs11758351 0.660 rs16891446 chr6:26226996 A/C cg08260959 chr6:26240920 HIST1H4F -0.35 -5.6 -0.3 4.44e-8 Gout;Renal underexcretion gout; CRC cis rs9733 0.596 rs7412396 chr1:150666797 C/T cg10589385 chr1:150898437 SETDB1 0.27 5.9 0.31 8.95e-9 Tonsillectomy; CRC cis rs8114671 0.562 rs2889861 chr20:33405664 C/T cg24642439 chr20:33292090 TP53INP2 0.36 5.8 0.3 1.54e-8 Height; CRC cis rs9311474 0.607 rs34005367 chr3:52558904 A/T cg08222913 chr3:52553049 STAB1 -0.37 -6.99 -0.36 1.51e-11 Electroencephalogram traits; CRC cis rs17767392 0.914 rs28859432 chr14:72010693 C/T cg13720639 chr14:72061746 SIPA1L1 -0.56 -6.93 -0.36 2.28e-11 Mitral valve prolapse; CRC trans rs2228479 0.702 rs17226841 chr16:89828484 C/T cg24644049 chr4:85504048 CDS1 0.86 6.93 0.36 2.29e-11 Skin colour saturation; CRC cis rs2625529 0.590 rs12904652 chr15:72548765 T/C cg16672083 chr15:72433130 SENP8 -0.41 -5.86 -0.31 1.13e-8 Red blood cell count; CRC cis rs875971 0.522 rs1917563 chr7:65415647 C/T cg00343986 chr7:65444356 GUSB -0.56 -8.5 -0.42 6.56e-16 Aortic root size; CRC trans rs1455244 0.700 rs7229302 chr18:11508904 G/T cg20468365 chr15:83419170 NA 0.4 6.1 0.32 3.02e-9 Schizophrenia; CRC cis rs7412746 0.634 rs12562939 chr1:150951452 A/C cg17724175 chr1:150552817 MCL1 0.47 6.91 0.36 2.47e-11 Melanoma; CRC cis rs2050392 0.624 rs303436 chr10:30731893 G/T cg25182066 chr10:30743637 MAP3K8 -0.44 -5.9 -0.31 9.1e-9 Inflammatory bowel disease; CRC cis rs2075371 0.966 rs1646646 chr7:133996905 G/T cg02659138 chr7:134003124 SLC35B4 0.38 6.47 0.34 3.54e-10 Mean platelet volume; CRC cis rs2014572 0.904 rs10412465 chr19:57753931 T/C cg24459738 chr19:57751996 ZNF805 -0.52 -8.19 -0.41 5.73e-15 Hyperactive-impulsive symptoms; CRC trans rs561341 0.941 rs2470236 chr17:30304940 G/C cg27661571 chr11:113659931 NA -0.77 -9.65 -0.47 1.43e-19 Hip circumference adjusted for BMI; CRC cis rs1865760 0.566 rs7772312 chr6:26049616 G/C cg16482183 chr6:26056742 HIST1H1C 0.52 7.48 0.38 6.66e-13 Height; CRC cis rs13118159 0.550 rs28733902 chr4:1374789 A/G cg16405210 chr4:1374714 KIAA1530 -0.95 -15.19 -0.64 7.44e-40 Longevity; CRC cis rs3741151 0.572 rs12290623 chr11:73121872 C/G cg17517138 chr11:73019481 ARHGEF17 0.52 5.66 0.3 3.36e-8 GIP levels in response to oral glucose tolerance test (120 minutes); CRC trans rs800082 0.516 rs12486882 chr3:144228481 A/G cg24215973 chr2:240111563 HDAC4 0.46 6.44 0.33 4.18e-10 Smoking behavior; CRC cis rs727563 0.635 rs5751149 chr22:42139501 A/G cg06634786 chr22:41940651 POLR3H 0.68 7.6 0.39 3.04e-13 Crohn's disease;Inflammatory bowel disease; CRC cis rs9611565 0.765 rs28604950 chr22:41785812 A/G cg03806693 chr22:41940476 POLR3H -1.01 -12.7 -0.57 2.36e-30 Vitiligo; CRC cis rs476633 0.691 rs28735224 chr15:41537539 C/T cg18705301 chr15:41695430 NDUFAF1 -0.4 -6.77 -0.35 5.83e-11 Glomerular filtration rate (creatinine); CRC cis rs7666738 0.830 rs72882693 chr4:98960804 T/A cg05340658 chr4:99064831 C4orf37 0.61 9.45 0.46 6.55e-19 Colonoscopy-negative controls vs population controls; CRC cis rs597539 0.652 rs592697 chr11:68650064 G/A cg04772025 chr11:68637568 NA 0.48 7.36 0.38 1.51e-12 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs9916302 0.660 rs4795367 chr17:37608843 G/C cg20243544 chr17:37824526 PNMT 0.47 5.61 0.3 4.22e-8 Glomerular filtration rate (creatinine); CRC cis rs4713118 0.824 rs9468225 chr6:27745719 T/G cg12273811 chr6:28175739 NA 0.52 6.83 0.35 4.08e-11 Parkinson's disease; CRC trans rs617791 0.508 rs2276132 chr11:65770545 G/A cg17712092 chr4:129076599 LARP1B -0.47 -6.81 -0.35 4.69e-11 Breast cancer; CRC cis rs561341 1.000 rs484175 chr17:30309041 G/A cg19193384 chr17:30244184 NA -0.65 -7.49 -0.38 6.27e-13 Hip circumference adjusted for BMI; CRC cis rs9868809 0.764 rs2633958 chr3:48635432 A/G cg00383909 chr3:49044727 WDR6 -0.79 -6.69 -0.35 9.4e-11 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; CRC cis rs2153535 0.580 rs9378552 chr6:8463748 G/A cg21535247 chr6:8435926 SLC35B3 0.5 7.53 0.38 4.89e-13 Motion sickness; CRC cis rs2227564 0.620 rs7098573 chr10:75580014 G/A cg00564723 chr10:75632066 CAMK2G -0.32 -7.6 -0.39 3.08e-13 Crohn's disease;Inflammatory bowel disease; CRC cis rs10979 0.965 rs7754452 chr6:143889028 G/A cg25407410 chr6:143891975 LOC285740 -0.82 -13.4 -0.59 5.5e-33 Hypospadias; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg12074057 chr3:124605640 ITGB5 0.43 6.11 0.32 2.88e-9 Response to antipsychotic treatment; CRC trans rs17685 0.712 rs6976236 chr7:75741087 G/T cg19862616 chr7:65841803 NCRNA00174 0.97 17.98 0.7 7.97e-51 Coffee consumption;Coffee consumption (cups per day); CRC trans rs916888 0.821 rs199507 chr17:44858855 A/G cg01341218 chr17:43662625 NA -0.83 -9.39 -0.46 1.03e-18 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC trans rs11722228 0.522 rs73212808 chr4:10055439 G/C cg26043149 chr18:55253948 FECH 1.11 18.13 0.71 2e-51 Gout;Urate levels;Serum uric acid levels; CRC cis rs10751667 0.666 rs7950967 chr11:955638 G/A cg06064525 chr11:970664 AP2A2 -0.31 -6.28 -0.33 1.07e-9 Alzheimer's disease (late onset); CRC cis rs477895 0.713 rs11601024 chr11:63943074 A/G cg19465662 chr11:63993652 NUDT22;TRPT1 0.72 8.9 0.44 3.84e-17 Mean platelet volume; CRC cis rs9733 0.744 rs11204725 chr1:150742700 T/C cg18016565 chr1:150552671 MCL1 -0.39 -5.65 -0.3 3.42e-8 Tonsillectomy; CRC cis rs2019137 0.560 rs7578633 chr2:113978650 C/T cg02675527 chr2:114030824 PAX8;LOC440839 -0.42 -6.17 -0.32 1.99e-9 Lymphocyte counts; CRC cis rs6662572 0.855 rs7517418 chr1:46252418 G/A cg03123370 chr1:45965343 CCDC163P;MMACHC -0.47 -6.12 -0.32 2.69e-9 Blood protein levels; CRC cis rs10206020 0.842 rs7590900 chr2:1574902 A/G cg12573674 chr2:1569213 NA -0.78 -10.48 -0.5 2.37e-22 IgG glycosylation; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg17050602 chr7:4681478 NA 0.45 6.09 0.32 3.12e-9 Anxiety disorder; CRC trans rs877282 0.533 rs10904565 chr10:819991 G/T cg22713356 chr15:30763199 NA 0.87 9.7 0.47 9.91e-20 Uric acid levels; CRC cis rs908922 0.676 rs569032 chr1:152508615 C/T cg09873164 chr1:152488093 CRCT1 0.39 6.41 0.33 5.17e-10 Hair morphology; CRC cis rs10504229 0.679 rs11783965 chr8:58130510 T/G cg22535103 chr8:58192502 C8orf71 -0.7 -9.33 -0.46 1.62e-18 Developmental language disorder (linguistic errors); CRC cis rs921968 0.612 rs832810 chr2:219322430 T/C cg02176678 chr2:219576539 TTLL4 0.49 8.05 0.41 1.58e-14 Mean corpuscular hemoglobin concentration; CRC cis rs10782582 0.609 rs5745347 chr1:76274520 C/T cg03433033 chr1:76189801 ACADM 0.41 5.88 0.31 9.87e-9 Daytime sleep phenotypes; CRC cis rs7772486 0.875 rs2814866 chr6:146339414 C/A cg23711669 chr6:146136114 FBXO30 0.61 10.25 0.49 1.43e-21 Lobe attachment (rater-scored or self-reported); CRC cis rs7647973 1.000 rs3448 chr3:49396751 T/C cg20833759 chr3:49053208 WDR6;DALRD3 0.55 8.2 0.41 5.38e-15 Menarche (age at onset); CRC cis rs6502050 0.835 rs7503189 chr17:80099486 C/A cg22110888 chr17:80059540 CCDC57 0.4 6.44 0.33 4.17e-10 Life satisfaction; CRC cis rs1129187 0.934 rs9471974 chr6:42918984 T/A cg03790207 chr6:42947109 PEX6 -0.45 -6.34 -0.33 7.56e-10 Alzheimer's disease in APOE e4+ carriers; CRC cis rs10927875 0.632 rs6677321 chr1:16149301 A/C cg21385522 chr1:16154831 NA -1.1 -19.24 -0.73 8.63e-56 Dilated cardiomyopathy; CRC cis rs10078 0.571 rs2721014 chr5:463539 G/A cg24955955 chr5:415729 AHRR 0.66 6.44 0.33 4.17e-10 Fat distribution (HIV); CRC cis rs738322 0.511 rs2267371 chr22:38577119 T/G cg25457927 chr22:38595422 NA -0.32 -6.07 -0.32 3.5e-9 Cutaneous nevi; CRC trans rs7301826 0.627 rs7315707 chr12:131272819 A/G cg01182386 chr15:75182373 MPI 0.49 6.25 0.33 1.28e-9 Plasma plasminogen activator levels; CRC cis rs3785574 1.000 rs7223257 chr17:61787684 T/C cg06873352 chr17:61820015 STRADA 0.49 7.9 0.4 4.35e-14 Height; CRC cis rs1552244 0.935 rs28815328 chr3:10062227 G/A cg10729496 chr3:10149963 C3orf24 0.49 6.47 0.34 3.6e-10 Alzheimer's disease; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg20456276 chr12:51157683 ATF1 0.46 6.52 0.34 2.66e-10 Anxiety disorder; CRC cis rs9916302 0.851 rs11870631 chr17:37645129 C/T cg15445000 chr17:37608096 MED1 0.43 9.47 0.46 5.76e-19 Glomerular filtration rate (creatinine); CRC cis rs4700695 0.668 rs36837 chr5:65480007 C/A cg21114390 chr5:65439923 SFRS12 -0.6 -8.16 -0.41 7.31e-15 Facial morphology (factor 19); CRC cis rs11098499 0.754 rs1980027 chr4:120251577 C/T cg09307838 chr4:120376055 NA 0.62 9.59 0.47 2.31e-19 Corneal astigmatism; CRC cis rs1005277 0.579 rs2472173 chr10:38374638 G/A cg25427524 chr10:38739819 LOC399744 -0.76 -13.54 -0.6 1.67e-33 Extrinsic epigenetic age acceleration; CRC cis rs3768617 0.565 rs3768626 chr1:183078462 A/G ch.1.3577855R chr1:183094577 LAMC1 0.87 15.32 0.65 2.28e-40 Fuchs's corneal dystrophy; CRC cis rs72945132 0.882 rs12294540 chr11:70118973 A/T cg14191688 chr11:70257035 CTTN 0.42 5.85 0.31 1.18e-8 Coronary artery disease; CRC cis rs2635047 0.542 rs1512235 chr18:44781569 A/G cg19077165 chr18:44547161 KATNAL2 -0.42 -6.32 -0.33 8.32e-10 Educational attainment; CRC cis rs1552244 1.000 rs113153120 chr3:10156398 G/A cg16606324 chr3:10149918 C3orf24 0.72 9.5 0.46 4.68e-19 Alzheimer's disease; CRC cis rs1891275 0.508 rs2096079 chr10:93496667 C/G cg07889827 chr10:93443413 NA -0.39 -6.46 -0.34 3.67e-10 Intelligence (multi-trait analysis); CRC cis rs870825 0.929 rs56106324 chr4:185589901 C/A cg04058563 chr4:185651563 MLF1IP 0.58 6.08 0.32 3.27e-9 Blood protein levels; CRC cis rs2404602 0.735 rs12906143 chr15:76709523 T/A cg23625390 chr15:77176239 SCAPER -0.83 -12.41 -0.56 2.76e-29 Blood metabolite levels; CRC cis rs9768139 0.708 rs921615 chr7:158117935 A/G cg23298862 chr7:158159286 PTPRN2 0.38 5.98 0.31 5.8e-9 Calcium levels; CRC trans rs3942852 0.774 rs11039519 chr11:48130094 G/C cg15704280 chr7:45808275 SEPT13 -0.61 -7.89 -0.4 4.6e-14 Acute lymphoblastic leukemia (childhood); CRC cis rs11758351 1.000 rs11755210 chr6:26202768 C/T cg22723502 chr6:26240528 HIST1H4F -0.39 -5.89 -0.31 9.33e-9 Gout;Renal underexcretion gout; CRC cis rs172166 0.637 rs1233691 chr6:28153897 T/G cg15786705 chr6:28176104 NA 0.68 10.39 0.5 4.62e-22 Cardiac Troponin-T levels; CRC cis rs7527798 0.592 rs6667118 chr1:207822724 G/T cg21110645 chr1:207815933 NA -0.41 -6.45 -0.34 3.95e-10 Erythrocyte sedimentation rate; CRC cis rs12477438 0.765 rs2167930 chr2:99592551 A/T cg26064155 chr2:99771622 LIPT1;TSGA10 -0.75 -10.56 -0.5 1.23e-22 Chronic sinus infection; CRC cis rs4665809 1.000 rs4665298 chr2:26256378 G/A cg26119090 chr2:26468346 HADHA;HADHB -0.6 -7.91 -0.4 4.08e-14 Gut microbiome composition (summer); CRC cis rs3741151 0.656 rs11544311 chr11:73106237 A/C cg17517138 chr11:73019481 ARHGEF17 0.97 7.95 0.4 2.97e-14 GIP levels in response to oral glucose tolerance test (120 minutes); CRC cis rs2075371 0.829 rs10954442 chr7:134007587 A/G cg02659138 chr7:134003124 SLC35B4 -0.42 -7.37 -0.38 1.42e-12 Mean platelet volume; CRC cis rs6951245 0.554 rs76243429 chr7:1152543 C/T cg22907277 chr7:1156413 C7orf50 0.89 11.67 0.54 1.42e-26 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs10089 1.000 rs3805607 chr5:127477418 T/C cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.76 10.68 0.51 4.61e-23 Ileal carcinoids; CRC cis rs7666738 0.830 rs17486413 chr4:99060544 G/T cg17366294 chr4:99064904 C4orf37 0.45 7.49 0.38 6.6e-13 Colonoscopy-negative controls vs population controls; CRC trans rs1814175 0.615 rs11040654 chr11:49939485 T/G cg15704280 chr7:45808275 SEPT13 -0.95 -16.82 -0.68 3.11e-46 Height; CRC trans rs10504229 1.000 rs68076606 chr8:58191271 A/G cg04077850 chr5:125800366 GRAMD3 0.37 6.27 0.33 1.15e-9 Developmental language disorder (linguistic errors); CRC cis rs896854 0.902 rs896852 chr8:95960886 G/T cg13393036 chr8:95962371 TP53INP1 -0.53 -8.91 -0.44 3.61e-17 Type 2 diabetes; CRC cis rs9902453 0.845 rs12602426 chr17:28158815 T/C cg26525008 chr17:28256777 EFCAB5;SSH2 0.58 8.74 0.43 1.22e-16 Coffee consumption (cups per day); CRC trans rs7615952 0.546 rs11718647 chr3:125352022 G/A cg16558177 chr4:4109446 NA -0.56 -6.77 -0.35 5.77e-11 Blood pressure (smoking interaction); CRC cis rs6540556 0.723 rs3765240 chr1:209918151 G/A cg23920097 chr1:209922102 NA -0.54 -6.71 -0.35 8.67e-11 Red blood cell count; CRC cis rs1552244 0.935 rs35515831 chr3:10071362 G/A cg10729496 chr3:10149963 C3orf24 0.5 6.64 0.34 1.28e-10 Alzheimer's disease; CRC cis rs7119 0.717 rs12910512 chr15:77817253 C/A cg10437265 chr15:77819839 NA 0.69 12.91 0.58 3.94e-31 Type 2 diabetes; CRC cis rs1832871 0.630 rs11754501 chr6:158710451 A/G cg07165851 chr6:158734300 TULP4 0.61 7.54 0.38 4.53e-13 Height; CRC cis rs8177253 1.000 rs3811647 chr3:133484029 G/A cg08048268 chr3:133502702 NA -0.37 -6.91 -0.36 2.49e-11 Iron status biomarkers; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg03467813 chr6:3851047 FAM50B 0.39 6.24 0.33 1.37e-9 Liver disease severity in Alagille syndrome; CRC cis rs12711979 0.513 rs4849991 chr2:3840545 T/G cg17052675 chr2:3827356 NA -0.35 -5.99 -0.31 5.6e-9 Itch intensity from mosquito bite adjusted by bite size; CRC cis rs875971 0.825 rs7384021 chr7:66077904 A/G cg18876405 chr7:65276391 NA -0.54 -8.57 -0.43 4.17e-16 Aortic root size; CRC cis rs2075671 0.810 rs12531792 chr7:100280624 G/A cg16850897 chr7:100343110 ZAN -0.61 -8.7 -0.43 1.61e-16 Other erythrocyte phenotypes; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg01019362 chr1:53163908 C1orf163 0.5 7.02 0.36 1.24e-11 Response to antipsychotic treatment; CRC cis rs7772486 0.719 rs7753770 chr6:146066161 G/A cg13319975 chr6:146136371 FBXO30 0.45 6.63 0.34 1.39e-10 Lobe attachment (rater-scored or self-reported); CRC cis rs9914988 0.943 rs9303621 chr17:27161138 A/G cg20469991 chr17:27169893 C17orf63 -0.59 -7.17 -0.37 5.14e-12 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs9926296 0.533 rs7190823 chr16:89866043 A/G cg03388025 chr16:89894329 SPIRE2 0.46 9.68 0.47 1.14e-19 Vitiligo; CRC cis rs1059312 0.808 rs11059921 chr12:129289919 C/T cg23521905 chr12:129298690 SLC15A4;MGC16384 0.35 6.1 0.32 3.04e-9 Systemic lupus erythematosus; CRC cis rs10504229 0.593 rs76118562 chr8:57988110 G/C cg02725872 chr8:58115012 NA -0.53 -7.23 -0.37 3.39e-12 Developmental language disorder (linguistic errors); CRC cis rs4862750 0.914 rs9995391 chr4:187873749 A/T cg07414643 chr4:187882934 NA -0.35 -5.94 -0.31 7.39e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs17666538 0.792 rs1669715 chr8:593641 T/C cg07685180 chr8:600429 NA 0.85 8.61 0.43 3.03e-16 IgG glycosylation; CRC cis rs995000 0.931 rs2131926 chr1:63026011 C/T cg19896129 chr1:63156450 NA -0.43 -6.67 -0.35 1.06e-10 Triglyceride levels; CRC cis rs1862618 0.802 rs252900 chr5:56185281 T/A cg20203395 chr5:56204925 C5orf35 -0.72 -8.29 -0.42 2.99e-15 Initial pursuit acceleration; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg00829269 chr20:44065852 NA 0.34 5.97 0.31 6.09e-9 Liver disease severity in Alagille syndrome; CRC cis rs7799006 0.634 rs34502289 chr7:2311266 G/A cg08027265 chr7:2291960 NA -0.47 -7.74 -0.39 1.2e-13 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs644799 0.710 rs10765771 chr11:95521044 A/G cg25478527 chr11:95522999 CEP57;FAM76B 0.49 7.61 0.39 3e-13 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs4638749 1.000 rs1466211 chr2:108856412 G/A cg25838818 chr2:108905173 SULT1C2 -0.39 -6.24 -0.33 1.39e-9 Blood pressure; CRC trans rs7395662 1.000 rs7121992 chr11:48592582 C/T cg21153622 chr11:89784906 NA -0.46 -7.31 -0.37 2.1e-12 HDL cholesterol; CRC cis rs7786808 0.741 rs11769149 chr7:158227127 A/G cg01191920 chr7:158217561 PTPRN2 0.89 17.16 0.69 1.43e-47 Obesity-related traits; CRC cis rs6860806 0.507 rs2631372 chr5:131703578 C/G cg22638593 chr5:131593259 PDLIM4 0.38 6.24 0.33 1.37e-9 Breast cancer; CRC cis rs1163251 0.902 rs639216 chr1:120217414 C/T cg19096424 chr1:120255104 PHGDH 0.46 6.65 0.34 1.2e-10 Blood metabolite levels; CRC trans rs9929218 0.954 rs4420522 chr16:68822971 A/G cg04657470 chr2:198365150 HSPE1;HSPD1 -0.78 -11.2 -0.53 6.79e-25 Colorectal cancer; CRC cis rs116979167 0.630 rs56230603 chr7:105165268 A/G cg02135003 chr7:105160482 PUS7 -0.91 -12.41 -0.56 2.87e-29 Bipolar disorder (body mass index interaction); CRC cis rs9325144 0.671 rs12818797 chr12:39019409 A/G cg26384229 chr12:38710491 ALG10B -0.5 -7.25 -0.37 3.08e-12 Morning vs. evening chronotype; CRC cis rs7119 0.700 rs7497168 chr15:77886231 A/C cg27398640 chr15:77910606 LINGO1 0.39 7.06 0.36 9.95e-12 Type 2 diabetes; CRC cis rs2075371 1.000 rs1421486 chr7:133985196 T/C cg20476274 chr7:133979776 SLC35B4 0.82 15.11 0.64 1.57e-39 Mean platelet volume; CRC cis rs4750440 0.702 rs4748066 chr10:14029313 A/T cg00551146 chr10:14014579 FRMD4A -0.36 -5.74 -0.3 2.16e-8 Adiponectin levels; CRC cis rs743757 1.000 rs2236984 chr3:50495487 A/C cg09545109 chr3:50388910 TUSC4;CYB561D2 0.44 6.37 0.33 6.54e-10 Diastolic blood pressure; CRC cis rs1843834 0.505 rs3820763 chr2:225347270 A/G cg22455342 chr2:225449267 CUL3 -0.65 -8.89 -0.44 4.04e-17 IgE levels in asthmatics (D.p. specific); CRC cis rs755249 0.567 rs4660214 chr1:39731550 T/C cg18385671 chr1:39797026 MACF1 -0.42 -5.96 -0.31 6.35e-9 Peripheral arterial disease (traffic-related air pollution interaction); CRC trans rs9329221 0.617 rs483916 chr8:9793601 A/C cg06636001 chr8:8085503 FLJ10661 -0.63 -10.33 -0.49 7.53e-22 Neuroticism; CRC cis rs11122272 0.766 rs2790872 chr1:231540543 A/T cg06096015 chr1:231504339 EGLN1 0.41 6.11 0.32 2.83e-9 Hemoglobin concentration; CRC cis rs1580019 0.885 rs1610141 chr7:32498435 C/T cg07520158 chr7:32535189 LSM5;AVL9 0.51 6.91 0.36 2.57e-11 Cognitive ability; CRC cis rs9902453 0.808 rs4595850 chr17:28206326 C/T cg26525008 chr17:28256777 EFCAB5;SSH2 0.57 8.61 0.43 3.06e-16 Coffee consumption (cups per day); CRC cis rs2882667 0.722 rs2011462 chr5:138162772 G/A cg09476006 chr5:138032270 NA -0.59 -10.72 -0.51 3.27e-23 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs11229555 0.645 rs12802960 chr11:58174775 T/C cg15696309 chr11:58395628 NA -0.82 -10.45 -0.5 2.95e-22 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; CRC cis rs9926296 0.585 rs6500450 chr16:89858024 A/G cg04287289 chr16:89883240 FANCA 0.81 14.47 0.62 4.55e-37 Vitiligo; CRC cis rs7772486 0.875 rs9399572 chr6:146362945 T/G cg23711669 chr6:146136114 FBXO30 0.68 11.85 0.55 3.22e-27 Lobe attachment (rater-scored or self-reported); CRC cis rs2032447 0.672 rs9379811 chr6:25955197 G/C cg04800585 chr6:26043546 HIST1H2BB 0.49 7.33 0.37 1.78e-12 Intelligence (multi-trait analysis); CRC cis rs3736485 0.966 rs7176044 chr15:51895343 T/C cg08986416 chr15:51914746 DMXL2 -0.47 -6.7 -0.35 9e-11 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs11098499 0.661 rs10015965 chr4:120268237 A/G cg24375607 chr4:120327624 NA 0.48 7.6 0.39 3.11e-13 Corneal astigmatism; CRC trans rs2303319 0.504 rs62188988 chr2:162531068 T/C cg13490827 chr1:46269305 MAST2 -0.71 -6.33 -0.33 7.97e-10 Cognitive function; CRC cis rs9467711 0.606 rs2072806 chr6:26385093 C/G cg14345882 chr6:26364793 BTN3A2 0.76 6.22 0.32 1.53e-9 Autism spectrum disorder or schizophrenia; CRC cis rs6496044 0.568 rs6496065 chr15:86075372 C/T cg17133734 chr15:86042851 AKAP13 0.4 6.49 0.34 3.21e-10 Interstitial lung disease; CRC cis rs9916302 0.904 rs2024073 chr17:37471330 T/G cg00129232 chr17:37814104 STARD3 0.56 8.23 0.41 4.4e-15 Glomerular filtration rate (creatinine); CRC cis rs6973256 0.897 rs4731970 chr7:133326602 C/T cg10665199 chr7:133106180 EXOC4 -0.37 -5.69 -0.3 2.77e-8 Intelligence (multi-trait analysis); CRC trans rs2710642 0.962 rs4671051 chr2:63032696 A/T cg05376469 chr2:102649931 NA 0.37 6.13 0.32 2.51e-9 LDL cholesterol levels;LDL cholesterol; CRC cis rs8180040 0.966 rs6765990 chr3:47542894 G/A cg27129171 chr3:47204927 SETD2 0.52 8.08 0.41 1.22e-14 Colorectal cancer; CRC cis rs365302 0.951 rs439251 chr6:159644198 C/T cg14500486 chr6:159655392 FNDC1 0.44 6.67 0.35 1.06e-10 Coronary heart disease; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg20257372 chr17:1945152 OVCA2;DPH1 0.39 6.55 0.34 2.26e-10 Liver disease severity in Alagille syndrome; CRC cis rs8103278 1.000 rs1548029 chr19:46309203 A/C cg16681516 chr19:46297285 DMWD 0.35 5.8 0.3 1.54e-8 Coronary artery disease; CRC cis rs2303759 0.709 rs8102574 chr19:49828897 A/G cg24324837 chr19:49891574 CCDC155 0.53 6.94 0.36 2.13e-11 Multiple sclerosis; CRC cis rs7193541 0.646 rs7188880 chr16:74664810 A/T cg01733217 chr16:74700730 RFWD3 1.07 22.87 0.78 5.93e-70 Multiple myeloma; CRC trans rs7615952 0.546 rs11718647 chr3:125352022 G/A cg00769240 chr8:12517080 NA -0.67 -7.82 -0.4 7.4e-14 Blood pressure (smoking interaction); CRC cis rs9322193 0.962 rs9767122 chr6:150104689 T/G cg07701084 chr6:150067640 NUP43 0.47 6.61 0.34 1.51e-10 Lung cancer; CRC trans rs116095464 0.558 rs9687898 chr5:253952 A/G cg00938859 chr5:1591904 SDHAP3 0.73 7.89 0.4 4.53e-14 Breast cancer; CRC cis rs3785574 0.962 rs2665842 chr17:61878535 G/A cg25654072 chr17:61904446 PSMC5;FTSJ3 0.43 6.06 0.32 3.71e-9 Height; CRC cis rs7927771 0.832 rs4752993 chr11:47410951 T/C cg18512352 chr11:47633146 NA 0.39 7.42 0.38 9.77e-13 Subjective well-being; CRC cis rs7660520 0.524 rs6839881 chr4:183729137 A/T cg25287198 chr4:183728479 NA 0.56 6.83 0.35 4.1e-11 Pediatric autoimmune diseases; CRC cis rs9915657 0.870 rs35271702 chr17:70140516 G/A cg09344028 chr17:70110421 NA 0.44 6.76 0.35 6.41e-11 Thyroid hormone levels; CRC cis rs7605827 0.930 rs10176967 chr2:15686086 G/T cg19274914 chr2:15703543 NA 0.39 5.82 0.31 1.4e-8 Educational attainment (years of education); CRC cis rs6163 0.588 rs3818708 chr10:104503584 C/T cg11453585 chr10:104263688 ACTR1A;SUFU -0.49 -7.67 -0.39 2e-13 Waist circumference;Hip circumference; CRC cis rs12701220 0.901 rs12701710 chr7:1090396 A/G cg26769984 chr7:1090371 C7orf50 -0.67 -10.06 -0.48 6.29e-21 Bronchopulmonary dysplasia; CRC cis rs12200560 0.505 rs211182 chr6:97074513 G/A cg06623918 chr6:96969491 KIAA0776 0.52 7.76 0.39 1.08e-13 Coronary heart disease; CRC cis rs6815814 0.950 rs11722889 chr4:38810975 C/T cg06935464 chr4:38784597 TLR10 0.55 5.69 0.3 2.78e-8 Breast cancer; CRC cis rs9868809 0.772 rs9841602 chr3:48713570 A/G cg07636037 chr3:49044803 WDR6 -0.61 -6.24 -0.33 1.35e-9 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; CRC cis rs4474465 0.850 rs4945294 chr11:78256864 G/A cg27205649 chr11:78285834 NARS2 0.52 6.66 0.34 1.13e-10 Alzheimer's disease (survival time); CRC cis rs17092148 0.836 rs6059910 chr20:33142107 T/C cg08999081 chr20:33150536 PIGU 0.51 6.51 0.34 2.85e-10 Neuroticism; CRC cis rs9818941 0.824 rs1123115 chr3:157813401 C/T cg08654915 chr3:157813417 NA 0.31 5.85 0.31 1.17e-8 Height; CRC cis rs7607369 0.791 rs72965151 chr2:219344165 G/T cg02176678 chr2:219576539 TTLL4 -0.61 -9.71 -0.47 8.96e-20 Red blood cell count;Amyotrophic lateral sclerosis; CRC cis rs6598955 0.671 rs12068212 chr1:26612935 C/T cg04990556 chr1:26633338 UBXN11 0.55 5.86 0.31 1.15e-8 Obesity-related traits; CRC cis rs9583531 0.657 rs7337126 chr13:111376788 A/G cg24331049 chr13:111365604 ING1 0.53 6.98 0.36 1.61e-11 Coronary artery disease; CRC cis rs3796352 1.000 rs71299622 chr3:52917038 G/A cg27565382 chr3:53032988 SFMBT1 0.8 6.32 0.33 8.4e-10 Immune reponse to smallpox (secreted IL-2); CRC cis rs763014 0.932 rs2384975 chr16:651115 G/T cg18653534 chr16:772142 FAM173A -0.35 -5.63 -0.3 3.96e-8 Height; CRC cis rs9894429 0.789 rs8074989 chr17:79598728 G/C cg21028142 chr17:79581711 NPLOC4 0.32 6.85 0.35 3.68e-11 Eye color traits; CRC cis rs17065868 0.764 rs9533869 chr13:45040702 T/C cg10246903 chr13:45222710 NA 0.54 5.69 0.3 2.79e-8 Antineutrophil cytoplasmic antibody-associated vasculitis; CRC cis rs12134245 0.776 rs12125947 chr1:91990487 T/C cg02896835 chr1:92012615 NA -0.63 -11.46 -0.53 8.3e-26 Breast cancer; CRC cis rs4409675 0.597 rs1000431 chr1:28225114 C/T cg23691781 chr1:28212827 C1orf38 0.31 7.24 0.37 3.17e-12 Corneal astigmatism; CRC cis rs9311474 0.607 rs11711421 chr3:52561779 C/T cg10802521 chr3:52805072 NEK4 -0.52 -8.33 -0.42 2.18e-15 Electroencephalogram traits; CRC cis rs4253772 0.550 rs6008601 chr22:46705326 C/G cg03482458 chr22:46692211 CN5H6.4;GTSE1 0.51 6.04 0.32 4.26e-9 LDL cholesterol;Cholesterol, total; CRC cis rs7618501 1.000 rs6802890 chr3:49832261 A/G cg24308560 chr3:49941425 MST1R -0.45 -7.28 -0.37 2.5e-12 Intelligence (multi-trait analysis); CRC cis rs473651 0.837 rs563458 chr2:239345613 T/A cg08773314 chr2:239334832 ASB1 0.38 8.67 0.43 1.98e-16 Multiple system atrophy; CRC trans rs3733585 0.578 rs6837224 chr4:9955255 G/T cg26043149 chr18:55253948 FECH -0.5 -7.78 -0.39 9.21e-14 Cleft plate (environmental tobacco smoke interaction); CRC trans rs7615952 0.688 rs17334074 chr3:125540460 A/G cg21747405 chr11:67723411 NA 0.42 5.97 0.31 6.1e-9 Blood pressure (smoking interaction); CRC cis rs282587 0.502 rs408476 chr13:113400056 A/C cg04656015 chr13:113407548 ATP11A 0.62 7.97 0.4 2.63e-14 Glycated hemoglobin levels; CRC cis rs7833790 0.724 rs6473309 chr8:82707880 A/G cg27398817 chr8:82754497 SNX16 -0.45 -6.13 -0.32 2.48e-9 Diastolic blood pressure; CRC cis rs6831352 1.000 rs1126670 chr4:100052733 C/A cg12011299 chr4:100065546 ADH4 0.51 10.49 0.5 2.06e-22 Alcohol dependence; CRC cis rs10927875 0.800 rs1627145 chr1:16328116 C/T cg22431228 chr1:16359049 CLCNKA -0.39 -6.87 -0.35 3.21e-11 Dilated cardiomyopathy; CRC cis rs727479 0.502 rs10046 chr15:51502986 G/A cg19946085 chr15:51559439 CYP19A1 -0.29 -5.83 -0.31 1.31e-8 Estradiol levels; CRC cis rs853679 1.000 rs11965538 chr6:28239915 G/A cg06470822 chr6:28175283 NA 0.67 6.62 0.34 1.48e-10 Depression; CRC cis rs7552404 0.961 rs1061337 chr1:76227022 A/G cg10523679 chr1:76189770 ACADM 0.84 11.58 0.54 3.13e-26 Blood metabolite levels;Acylcarnitine levels; CRC cis rs9926296 0.533 rs9938865 chr16:89867797 A/G cg04287289 chr16:89883240 FANCA 0.84 15.55 0.65 3.02e-41 Vitiligo; CRC cis rs6502050 0.865 rs8073679 chr17:80155343 G/A cg22110888 chr17:80059540 CCDC57 0.41 6.44 0.33 4.27e-10 Life satisfaction; CRC cis rs6938 0.597 rs11856413 chr15:75199892 A/G cg14664628 chr15:75095509 CSK -0.6 -9.06 -0.45 1.2e-17 Breast cancer; CRC cis rs938554 0.784 rs16868246 chr4:9978305 C/G cg00071950 chr4:10020882 SLC2A9 0.45 6.45 0.34 3.98e-10 Blood metabolite levels; CRC trans rs6076960 0.684 rs3852947 chr20:6255341 A/G cg24759859 chr6:86352639 SYNCRIP 0.48 6.75 0.35 6.54e-11 Smooth-surface caries; CRC cis rs9443645 0.901 rs9343856 chr6:79678211 G/A cg11833968 chr6:79620685 NA -0.37 -6.27 -0.33 1.16e-9 Intelligence (multi-trait analysis); CRC cis rs9611565 0.513 rs739135 chr22:42090069 A/C cg06481639 chr22:41940642 POLR3H 0.52 5.89 0.31 9.36e-9 Vitiligo; CRC cis rs2839186 0.732 rs8131458 chr21:47694712 G/A cg09417038 chr21:47716443 C21orf57 -0.52 -8.69 -0.43 1.7e-16 Testicular germ cell tumor; CRC cis rs7208859 0.673 rs2433 chr17:29226228 T/C cg01831904 chr17:28903510 LRRC37B2 -0.56 -5.83 -0.31 1.35e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs10504229 0.861 rs116964504 chr8:58185354 A/C cg02725872 chr8:58115012 NA -0.38 -6.43 -0.33 4.44e-10 Developmental language disorder (linguistic errors); CRC cis rs6502050 0.835 rs56232956 chr17:80078929 C/T cg02741985 chr17:80059408 CCDC57 -0.44 -7.17 -0.37 4.96e-12 Life satisfaction; CRC cis rs6582630 0.519 rs12368889 chr12:38315160 G/A cg13010199 chr12:38710504 ALG10B 0.44 5.64 0.3 3.7e-8 Drug-induced liver injury (flucloxacillin); CRC cis rs1580019 0.961 rs4255041 chr7:32496383 A/G cg07520158 chr7:32535189 LSM5;AVL9 0.45 6.48 0.34 3.4e-10 Cognitive ability; CRC cis rs6831352 0.918 rs2851247 chr4:100046091 C/G cg13256891 chr4:100009986 ADH5 -0.71 -9.33 -0.46 1.56e-18 Alcohol dependence; CRC cis rs6921919 0.697 rs758398 chr6:28320674 C/T cg06470822 chr6:28175283 NA 0.49 6.55 0.34 2.16e-10 Autism spectrum disorder or schizophrenia; CRC trans rs944990 0.595 rs10123378 chr9:96375217 C/T cg09898070 chr2:48009866 MSH6 0.45 7.15 0.37 5.51e-12 Body mass index; CRC cis rs10256972 0.591 rs6950319 chr7:1161324 A/G cg03923535 chr7:1197113 ZFAND2A 0.64 9.19 0.45 4.6e-18 Longevity;Endometriosis; CRC cis rs7737355 0.947 rs1422871 chr5:130942481 G/A cg06307176 chr5:131281290 NA 0.48 6.77 0.35 5.94e-11 Life satisfaction; CRC cis rs11764590 0.715 rs9969125 chr7:2088460 C/T cg21155852 chr7:2048760 MAD1L1 -0.45 -5.88 -0.31 1e-8 Neuroticism; CRC cis rs4561483 0.801 rs4511557 chr16:11949458 T/C cg08843971 chr16:11963173 GSPT1 0.62 9.76 0.47 6.12e-20 Testicular germ cell tumor; CRC cis rs7274811 0.688 rs6141400 chr20:32056087 C/T cg03904042 chr20:32255491 NECAB3;C20orf134 -0.41 -5.88 -0.31 1e-8 Height; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg01285435 chr8:145654565 VPS28;NFKBIL2 0.38 7.05 0.36 1.04e-11 Liver disease severity in Alagille syndrome; CRC cis rs59104589 0.583 rs73002176 chr2:242332438 T/C cg19488206 chr2:242435732 STK25 0.48 6.78 0.35 5.73e-11 Fibrinogen levels; CRC cis rs60594510 1 rs60594510 chr12:110594503 C/T cg12870014 chr12:110450643 ANKRD13A 0.83 10.65 0.51 5.74e-23 Intelligence (multi-trait analysis); CRC cis rs7618915 0.547 rs11720432 chr3:52672742 T/C cg18404041 chr3:52824283 ITIH1 -0.44 -9.03 -0.45 1.43e-17 Bipolar disorder; CRC cis rs2932538 0.922 rs7551933 chr1:113086706 C/T cg22162597 chr1:113214053 CAPZA1 -0.68 -9.61 -0.47 1.96e-19 Systolic blood pressure;Diastolic blood pressure;Hypertension;Blood pressure; CRC cis rs2046867 0.818 rs9814945 chr3:72803590 C/T cg25664220 chr3:72788482 NA -0.39 -5.92 -0.31 8.18e-9 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; CRC cis rs11229555 0.874 rs11229505 chr11:58274155 T/C cg15696309 chr11:58395628 NA -0.96 -12.72 -0.57 1.96e-30 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; CRC cis rs12431939 0.948 rs12435916 chr14:51665858 T/G cg23942311 chr14:51606299 NA -0.51 -6.19 -0.32 1.77e-9 Cancer; CRC cis rs9517320 0.515 rs9556972 chr13:99209815 C/T cg07423050 chr13:99094983 FARP1 -0.54 -7.59 -0.39 3.34e-13 Longevity; CRC cis rs728616 0.867 rs75447386 chr10:81739647 G/A cg05935833 chr10:81318306 SFTPA2 -0.76 -8.28 -0.42 3.12e-15 Chronic obstructive pulmonary disease-related biomarkers; CRC trans rs8029989 0.869 rs8039162 chr15:38740829 A/G cg11248668 chr11:45826493 SLC35C1 0.38 5.96 0.31 6.35e-9 Psychosis (atypical); CRC cis rs2762353 0.524 rs3923 chr6:25783315 T/C cg16482183 chr6:26056742 HIST1H1C -0.5 -6.77 -0.35 5.86e-11 Blood metabolite levels; CRC cis rs62432291 0.681 rs435521 chr6:159662638 C/T cg14500486 chr6:159655392 FNDC1 0.74 9.75 0.47 6.82e-20 Joint mobility (Beighton score); CRC cis rs977987 0.778 rs4888409 chr16:75436231 A/T cg03315344 chr16:75512273 CHST6 0.54 9.08 0.45 1.01e-17 Dupuytren's disease; CRC cis rs4481887 0.927 rs4453081 chr1:248475691 C/G cg13385794 chr1:248469461 NA 0.38 6.75 0.35 6.53e-11 Common traits (Other); CRC cis rs9399186 1.000 rs12176346 chr6:136732664 C/T cg11114242 chr6:136756541 MAP7 0.48 6.62 0.34 1.45e-10 Pursuit maintenance gain; CRC cis rs1799949 0.965 rs8176323 chr17:41195711 G/C cg25072359 chr17:41440525 NA 0.45 6.86 0.35 3.34e-11 Menopause (age at onset); CRC cis rs6951245 1.000 rs2363286 chr7:1091625 A/G cg04025307 chr7:1156635 C7orf50 0.55 5.93 0.31 7.65e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs7666738 0.830 rs1456208 chr4:98678563 C/T cg05340658 chr4:99064831 C4orf37 0.56 8.43 0.42 1.12e-15 Colonoscopy-negative controls vs population controls; CRC cis rs1862618 0.641 rs2591954 chr5:56245044 G/C cg24531977 chr5:56204891 C5orf35 0.66 10.27 0.49 1.24e-21 Initial pursuit acceleration; CRC cis rs3785574 1.000 rs3785574 chr17:61763185 T/C cg06873352 chr17:61820015 STRADA 0.5 7.76 0.39 1.06e-13 Height; CRC cis rs1218582 0.628 rs12130132 chr1:154880386 C/T cg24250549 chr1:154909240 PMVK 0.59 8.69 0.43 1.72e-16 Prostate cancer; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg06620762 chr15:76136437 UBE2Q2 0.53 7.01 0.36 1.37e-11 Thyroid stimulating hormone; CRC cis rs12580194 0.593 rs55659159 chr12:55747754 C/T cg19537932 chr12:55886519 OR6C68 -0.66 -8.56 -0.43 4.26e-16 Cancer; CRC cis rs270601 0.710 rs4705852 chr5:131602807 A/G cg18758796 chr5:131593413 PDLIM4 0.48 8.82 0.44 7.04e-17 Acylcarnitine levels; CRC cis rs6502050 0.805 rs9898507 chr17:80119628 C/T cg19223190 chr17:80058835 NA 0.39 6.23 0.32 1.43e-9 Life satisfaction; CRC cis rs9534288 0.742 rs1022952 chr13:46649348 C/T cg15192986 chr13:46630673 CPB2 0.62 8.75 0.43 1.11e-16 Blood protein levels; CRC cis rs1552244 1.000 rs7615764 chr3:10082592 C/T cg08888203 chr3:10149979 C3orf24 0.73 10.08 0.49 5.45e-21 Alzheimer's disease; CRC trans rs11098499 0.954 rs11729521 chr4:120416788 T/C cg25214090 chr10:38739885 LOC399744 0.65 10.13 0.49 3.71e-21 Corneal astigmatism; CRC cis rs600806 0.854 rs11102974 chr1:109886371 G/A cg23032129 chr1:109941072 SORT1 -0.27 -5.79 -0.3 1.64e-8 Intelligence (multi-trait analysis); CRC cis rs9733 0.596 rs6669369 chr1:150695892 C/T cg10589385 chr1:150898437 SETDB1 0.28 5.96 0.31 6.66e-9 Tonsillectomy; CRC cis rs2806561 0.929 rs628096 chr1:23537676 C/G cg19743168 chr1:23544995 NA 0.37 5.94 0.31 7.21e-9 Height; CRC cis rs116095464 0.558 rs28558836 chr5:285748 C/G cg22857025 chr5:266934 NA -1.18 -16.13 -0.66 1.55e-43 Breast cancer; CRC cis rs17345786 0.511 rs1138818 chr3:101399583 C/G cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.62 8.41 0.42 1.3e-15 Colonoscopy-negative controls vs population controls; CRC cis rs2976388 0.609 rs2572907 chr8:143801938 G/A cg22687807 chr8:143858763 LYNX1 0.48 8.58 0.43 3.68e-16 Urinary tract infection frequency; CRC cis rs9894429 0.646 rs7210026 chr17:79612382 T/C cg21028142 chr17:79581711 NPLOC4 0.34 7.09 0.36 8.14e-12 Eye color traits; CRC cis rs1712517 0.771 rs7074749 chr10:105116056 C/T cg05636881 chr10:105038444 INA 0.47 8.08 0.41 1.2e-14 Migraine; CRC cis rs763121 0.853 rs2205802 chr22:39046327 T/C cg06022373 chr22:39101656 GTPBP1 0.78 12.39 0.56 3.54e-29 Menopause (age at onset); CRC cis rs1153858 1.000 rs4774579 chr15:45651803 G/A cg10760299 chr15:45669010 GATM 0.52 8.29 0.42 2.96e-15 Homoarginine levels; CRC trans rs7618501 0.815 rs3819325 chr3:49843723 T/C cg21659725 chr3:3221576 CRBN 0.88 16.37 0.67 1.71e-44 Intelligence (multi-trait analysis); CRC cis rs7618915 0.547 rs13085895 chr3:52678270 G/C cg18099408 chr3:52552593 STAB1 -0.43 -7.08 -0.36 8.86e-12 Bipolar disorder; CRC trans rs3780486 0.505 rs10758194 chr9:33157419 G/T cg20290983 chr6:43655470 MRPS18A 0.95 17.39 0.69 1.66e-48 IgG glycosylation; CRC cis rs12325245 0.536 rs12931051 chr16:58626534 C/T cg01472538 chr16:58549086 SETD6 1.12 7.38 0.38 1.28e-12 Schizophrenia; CRC cis rs1707322 0.929 rs785513 chr1:46538320 T/C cg06784218 chr1:46089804 CCDC17 -0.54 -9.36 -0.46 1.32e-18 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC trans rs2303319 0.504 rs12469052 chr2:162319353 T/C cg19471553 chr17:41393123 NA -0.7 -6.07 -0.32 3.48e-9 Cognitive function; CRC cis rs4862750 0.914 rs10027250 chr4:187873460 T/C cg10295955 chr4:187884368 NA -0.97 -21.38 -0.76 3.42e-64 Lobe attachment (rater-scored or self-reported); CRC cis rs12893668 0.572 rs11540512 chr14:104147377 C/T cg08213375 chr14:104286397 PPP1R13B 0.44 6.89 0.36 2.77e-11 Reticulocyte count; CRC cis rs72772090 0.539 rs11747896 chr5:96113397 A/G cg17330273 chr5:96107758 CAST;ERAP1 0.6 5.76 0.3 1.93e-8 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg00837765 chr8:74884459 TCEB1 0.37 6.14 0.32 2.39e-9 Liver disease severity in Alagille syndrome; CRC trans rs113835537 0.627 rs4630309 chr11:66333072 A/C cg22456192 chr18:71959684 CYB5A 0.59 6.28 0.33 1.09e-9 Airway imaging phenotypes; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg04867738 chr17:42298359 UBTF 0.4 6.47 0.34 3.59e-10 Liver disease severity in Alagille syndrome; CRC cis rs2115630 0.645 rs1107179 chr15:85198362 A/C cg11189052 chr15:85197271 WDR73 0.71 12.56 0.57 8.05e-30 P wave terminal force; CRC cis rs3768617 0.510 rs10911249 chr1:183080690 G/A ch.1.3577855R chr1:183094577 LAMC1 0.88 15.62 0.65 1.5e-41 Fuchs's corneal dystrophy; CRC cis rs2302190 1.000 rs8065388 chr17:56562132 C/T cg25885038 chr17:56607967 SEPT4 -0.46 -7.14 -0.37 5.86e-12 Vitamin D levels; CRC cis rs2421770 0.530 rs10836375 chr11:35353842 C/T cg13971030 chr11:35366721 SLC1A2 -0.37 -6.17 -0.32 1.98e-9 Staphylococcus aureus nasal carriage (persistent); CRC cis rs7677751 0.767 rs11133315 chr4:55082158 G/A cg17187183 chr4:55093834 PDGFRA 0.52 7.6 0.39 3.21e-13 Corneal astigmatism; CRC cis rs11098499 0.908 rs71614449 chr4:120387055 C/T cg24375607 chr4:120327624 NA 0.5 7.72 0.39 1.4e-13 Corneal astigmatism; CRC cis rs2062225 0.935 rs1384795 chr2:111771647 A/G cg11729679 chr2:111877065 BCL2L11 -0.56 -5.62 -0.3 4.08e-8 Monocyte count; CRC cis rs6840360 0.571 rs4696100 chr4:152514242 C/T cg09659197 chr4:152720779 NA 0.31 5.67 0.3 3.05e-8 Intelligence (multi-trait analysis); CRC cis rs1552244 0.752 rs9867091 chr3:10043429 T/C cg18598329 chr3:10140678 FANCD2;C3orf24 -0.83 -11.58 -0.54 2.98e-26 Alzheimer's disease; CRC cis rs12188164 0.620 rs1043356 chr5:480948 C/T cg16322479 chr5:444228 EXOC3;C5orf55 -0.54 -7.64 -0.39 2.36e-13 Cystic fibrosis severity; CRC trans rs34421088 0.548 rs2618443 chr8:11384556 A/G cg06636001 chr8:8085503 FLJ10661 -0.49 -7.18 -0.37 4.69e-12 Neuroticism; CRC cis rs7659604 0.582 rs3217780 chr4:122737278 T/C cg23574427 chr4:122746245 BBS7;CCNA2 -0.3 -5.7 -0.3 2.71e-8 Type 2 diabetes; CRC cis rs6141769 0.542 rs28456361 chr20:31299597 T/C cg13636640 chr20:31349939 DNMT3B -0.39 -5.84 -0.31 1.27e-8 Subjective well-being; CRC cis rs1005224 0.963 rs2302592 chr14:76129287 C/G cg04684003 chr14:76127793 TTLL5;C14orf1 0.46 6.41 0.33 5.05e-10 Large artery stroke; CRC cis rs939658 0.626 rs11631406 chr15:79445789 C/T cg17916960 chr15:79447300 NA -0.39 -6.43 -0.33 4.51e-10 Refractive error; CRC cis rs17376456 0.877 rs7728736 chr5:93404277 C/T cg21475434 chr5:93447410 FAM172A 0.72 7.73 0.39 1.31e-13 Diabetic retinopathy; CRC cis rs911119 0.909 rs3761279 chr20:23620075 C/G cg16589663 chr20:23618590 CST3 0.62 8.01 0.4 2.01e-14 Chronic kidney disease; CRC cis rs741668 0.931 rs7317990 chr13:46568497 C/T cg06018095 chr13:46550134 ZC3H13 0.41 5.73 0.3 2.21e-8 Cerebrospinal fluid clusterin levels; CRC cis rs10504229 1.000 rs17216957 chr8:58179893 C/T cg24829409 chr8:58192753 C8orf71 -0.68 -11.34 -0.53 2.27e-25 Developmental language disorder (linguistic errors); CRC cis rs1129187 0.967 rs6941212 chr6:42915920 A/G cg21280719 chr6:42927975 GNMT -0.43 -9.34 -0.46 1.49e-18 Alzheimer's disease in APOE e4+ carriers; CRC cis rs1552244 0.872 rs6771931 chr3:10113408 C/G cg00166722 chr3:10149974 C3orf24 0.66 9.0 0.44 1.85e-17 Alzheimer's disease; CRC trans rs6500957 0.920 rs17648524 chr16:7459683 C/G cg16416152 chr16:67193901 FBXL8;TRADD 0.4 5.97 0.31 6.17e-9 Spherical equivalent (joint analysis main effects and education interaction); CRC cis rs60871478 0.685 rs34421533 chr7:816638 A/G cg05535760 chr7:792225 HEATR2 1.01 11.95 0.55 1.34e-27 Cerebrospinal P-tau181p levels; CRC trans rs7726839 0.540 rs3792720 chr5:643028 T/G cg25482853 chr8:67687455 SGK3 1.11 13.07 0.58 9.93e-32 Obesity-related traits; CRC cis rs2635047 0.837 rs2571009 chr18:44650279 A/G cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.46 7.57 0.39 3.69e-13 Educational attainment; CRC cis rs2032447 0.765 rs6942072 chr6:26014987 A/G cg27635394 chr6:26043820 HIST1H2BB 0.42 6.19 0.32 1.77e-9 Intelligence (multi-trait analysis); CRC cis rs17401966 0.931 rs4846205 chr1:10310214 A/T cg19773385 chr1:10388646 KIF1B -0.69 -11.44 -0.53 9.78e-26 Hepatocellular carcinoma; CRC cis rs2239547 0.657 rs6445539 chr3:52874296 G/A cg11645453 chr3:52864694 ITIH4 0.6 10.66 0.51 5.32e-23 Schizophrenia; CRC trans rs7618501 0.602 rs6780731 chr3:50017478 A/G cg21665057 chr3:196295764 WDR53;FBXO45 0.61 9.54 0.47 3.22e-19 Intelligence (multi-trait analysis); CRC cis rs6933660 0.646 rs9397410 chr6:151770503 C/T cg14416726 chr6:151773293 C6orf211;RMND1 -0.76 -12.49 -0.57 1.45e-29 Menarche (age at onset); CRC cis rs7264396 0.690 rs17093156 chr20:34438583 T/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.59 -10.11 -0.49 4.17e-21 Total cholesterol levels; CRC cis rs478304 0.654 rs12289836 chr11:65436888 C/T cg27068330 chr11:65405492 SIPA1 0.76 11.47 0.53 7.62e-26 Acne (severe); CRC cis rs7811142 1.000 rs76913697 chr7:100002772 A/G cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.17 17.35 0.69 2.37e-48 Platelet count; CRC cis rs561341 1.000 rs72821971 chr17:30269343 T/G cg00745463 chr17:30367425 LRRC37B -0.89 -9.79 -0.48 4.8e-20 Hip circumference adjusted for BMI; CRC cis rs4713118 0.513 rs149962 chr6:28015918 G/A cg15786705 chr6:28176104 NA 0.58 8.28 0.42 3.04e-15 Parkinson's disease; CRC cis rs12545109 0.800 rs2609979 chr8:57390066 G/A cg09654669 chr8:57350985 NA -0.39 -5.65 -0.3 3.47e-8 Obesity-related traits; CRC cis rs950169 1.000 rs1818950 chr15:84722521 A/G cg24253500 chr15:84953950 NA 0.37 6.25 0.33 1.24e-9 Schizophrenia; CRC cis rs12586317 0.547 rs2273154 chr14:35433187 C/T cg05294307 chr14:35346193 BAZ1A -0.7 -7.66 -0.39 2.09e-13 Psoriasis; CRC cis rs3815700 1.000 rs8101356 chr19:33093402 C/T cg02997394 chr19:33096574 ANKRD27 0.75 8.68 0.43 1.88e-16 Eosinophilic esophagitis; CRC cis rs728616 0.681 rs12413174 chr10:82062404 G/A cg11900509 chr10:81946545 ANXA11 -0.54 -5.94 -0.31 7.23e-9 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs875971 1.000 rs1167612 chr7:65567976 C/A cg18912574 chr7:65842487 NCRNA00174 -0.36 -6.25 -0.33 1.31e-9 Aortic root size; CRC trans rs11039798 1.000 rs7125913 chr11:48984318 G/A cg03929089 chr4:120376271 NA 0.64 6.1 0.32 2.95e-9 Axial length; CRC cis rs7917772 0.636 rs2482499 chr10:104516246 G/A cg04362960 chr10:104952993 NT5C2 -0.47 -6.24 -0.33 1.34e-9 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC cis rs1552244 0.882 rs17050699 chr3:10037167 G/A cg16606324 chr3:10149918 C3orf24 0.62 8.08 0.41 1.25e-14 Alzheimer's disease; CRC cis rs514406 0.547 rs377808 chr1:53190359 T/G cg24675658 chr1:53192096 ZYG11B -0.7 -10.73 -0.51 3.06e-23 Monocyte count; CRC cis rs2404602 0.709 rs11072591 chr15:76649562 A/G cg23625390 chr15:77176239 SCAPER 0.83 13.49 0.6 2.63e-33 Blood metabolite levels; CRC cis rs7917772 0.582 rs10748826 chr10:104354804 T/C cg11453585 chr10:104263688 ACTR1A;SUFU 0.82 15.29 0.64 3.12e-40 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC cis rs4731207 0.565 rs6466978 chr7:124643786 G/A cg23710748 chr7:124431027 NA -0.39 -6.17 -0.32 1.99e-9 Cutaneous malignant melanoma; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg09805055 chr2:208634004 FZD5 0.46 6.35 0.33 7.13e-10 Response to antipsychotic treatment; CRC cis rs4665809 1.000 rs6546744 chr2:26302161 A/G cg25036284 chr2:26402008 FAM59B -0.46 -6.02 -0.31 4.69e-9 Gut microbiome composition (summer); CRC cis rs10504229 0.861 rs116923397 chr8:58185162 T/G cg02725872 chr8:58115012 NA -0.38 -6.45 -0.33 4.06e-10 Developmental language disorder (linguistic errors); CRC cis rs10174077 0.874 rs10186656 chr2:152475938 T/G cg06191203 chr2:152266755 RIF1 -0.6 -8.47 -0.42 8.04e-16 Squamous cell lung carcinoma; CRC cis rs12983728 0.536 rs34380569 chr19:58648528 A/G cg08687515 chr19:58661962 ZNF329 0.51 6.32 0.33 8.48e-10 Cholesterol, total; CRC cis rs10503871 0.584 rs7831616 chr8:30449536 A/G cg26383811 chr8:30366931 RBPMS -0.39 -5.8 -0.3 1.53e-8 Metabolite levels (X-11787); CRC cis rs875971 1.000 rs6979382 chr7:65886375 C/T cg12463550 chr7:65579703 CRCP 0.5 7.14 0.37 6.16e-12 Aortic root size; CRC cis rs7274811 0.681 rs186026 chr20:31951993 G/T cg07470512 chr20:32255052 NECAB3;C20orf134 0.42 5.66 0.3 3.22e-8 Height; CRC cis rs7833986 0.501 rs72653986 chr8:57035048 T/C cg23139584 chr8:56987506 RPS20;SNORD54 0.91 12.3 0.56 7.27e-29 Height; CRC cis rs79349575 0.749 rs58838744 chr17:46998902 A/G cg00947319 chr17:47005597 UBE2Z -0.34 -5.87 -0.31 1.06e-8 Type 2 diabetes; CRC trans rs7618501 1.000 rs2271960 chr3:49878078 A/G cg21659725 chr3:3221576 CRBN 0.81 14.29 0.62 2.3e-36 Intelligence (multi-trait analysis); CRC cis rs6499255 0.904 rs2161631 chr16:69556948 C/A cg15192750 chr16:69999425 NA 0.47 6.34 0.33 7.63e-10 IgE levels; CRC cis rs12620999 1.000 rs28727919 chr2:238003313 C/T cg23555395 chr2:238036564 NA 0.61 9.65 0.47 1.47e-19 Systemic lupus erythematosus; CRC trans rs2303319 0.582 rs62187614 chr2:162436285 C/G cg18122310 chr12:50236657 BCDIN3D -0.73 -6.01 -0.31 4.93e-9 Cognitive function; CRC cis rs7044106 0.708 rs920745 chr9:123429943 T/C cg09586646 chr9:123605570 PSMD5;LOC253039 0.61 8.91 0.44 3.44e-17 Hip circumference adjusted for BMI; CRC cis rs1005277 0.579 rs2474580 chr10:38398713 G/A cg00409905 chr10:38381863 ZNF37A -0.68 -11.33 -0.53 2.33e-25 Extrinsic epigenetic age acceleration; CRC cis rs514406 0.505 rs374662 chr1:53164549 C/A cg08859206 chr1:53392774 SCP2 -0.39 -5.91 -0.31 8.48e-9 Monocyte count; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg12013492 chr11:46143011 PHF21A 0.42 6.72 0.35 7.95e-11 Liver disease severity in Alagille syndrome; CRC cis rs514406 0.548 rs6670871 chr1:53212082 A/C cg25767906 chr1:53392781 SCP2 0.42 6.67 0.35 1.09e-10 Monocyte count; CRC cis rs116095464 0.558 rs6866776 chr5:264495 C/T cg22857025 chr5:266934 NA -1.25 -16.78 -0.68 4.42e-46 Breast cancer; CRC cis rs9486715 0.867 rs3860243 chr6:96905303 T/G cg06623918 chr6:96969491 KIAA0776 1.01 20.08 0.74 4.1e-59 Headache; CRC cis rs651907 0.535 rs34161138 chr3:101510388 T/C cg12386194 chr3:101231763 SENP7 0.52 7.45 0.38 8.17e-13 Colorectal cancer; CRC cis rs9902453 0.791 rs3115100 chr17:28045744 T/C cg26525008 chr17:28256777 EFCAB5;SSH2 0.7 11.77 0.54 6.24e-27 Coffee consumption (cups per day); CRC cis rs12422267 0.536 rs11246933 chr12:132610314 G/A cg09764611 chr12:132620959 NA -0.63 -8.39 -0.42 1.5e-15 Plasma amyloid beta peptide concentrations (ABx-40); CRC cis rs752010 0.714 rs2148635 chr1:42082452 C/T cg06885757 chr1:42089581 HIVEP3 -0.44 -7.92 -0.4 3.82e-14 Lupus nephritis in systemic lupus erythematosus; CRC cis rs9322193 0.923 rs6913486 chr6:150026196 C/T cg07701084 chr6:150067640 NUP43 -0.56 -7.89 -0.4 4.61e-14 Lung cancer; CRC cis rs7904368 1.000 rs7904368 chr10:16858587 C/T cg23933602 chr10:16859644 RSU1 0.69 9.21 0.45 3.87e-18 Ratio of the peak velocity of the mitral E-Wave divided by the peak velocity of the mitral A-wave.; CRC cis rs9467711 0.606 rs16891725 chr6:26479150 C/T cg16898833 chr6:26189333 HIST1H4D 0.83 7.22 0.37 3.65e-12 Autism spectrum disorder or schizophrenia; CRC cis rs12541635 0.966 rs6469023 chr8:106989558 T/C cg10147462 chr8:107024639 NA 0.45 7.34 0.38 1.65e-12 Age of smoking initiation; CRC cis rs10971721 0.554 rs10971712 chr9:33820938 C/T cg13495928 chr9:33750294 PRSS3 0.55 5.89 0.31 9.66e-9 Body mass index; CRC cis rs597539 0.616 rs72945243 chr11:68633358 T/C cg04772025 chr11:68637568 NA 0.51 8.22 0.41 4.88e-15 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC trans rs561341 1.000 rs113115092 chr17:30284164 G/A cg20587970 chr11:113659929 NA -1.43 -20.42 -0.75 2e-60 Hip circumference adjusted for BMI; CRC cis rs55702914 1.000 rs56234206 chr2:198215995 T/A cg10820045 chr2:198174542 NA 0.34 6.09 0.32 3.07e-9 Major depression and alcohol dependence; CRC cis rs17345786 1.000 rs11715368 chr3:101336380 G/A cg12386194 chr3:101231763 SENP7 0.57 7.53 0.38 4.84e-13 Colonoscopy-negative controls vs population controls; CRC cis rs763121 0.853 rs5757208 chr22:39049230 A/C cg06022373 chr22:39101656 GTPBP1 0.78 12.35 0.56 4.64e-29 Menopause (age at onset); CRC cis rs1215050 0.755 rs811479 chr4:98727398 A/T cg05340658 chr4:99064831 C4orf37 0.47 6.86 0.35 3.43e-11 Waist-to-hip ratio adjusted for body mass index; CRC cis rs2243480 1.000 rs316315 chr7:65591205 C/T cg25985355 chr7:65971099 NA 0.45 6.07 0.32 3.52e-9 Diabetic kidney disease; CRC cis rs9894429 0.966 rs6565601 chr17:79580173 C/T cg21028142 chr17:79581711 NPLOC4 0.39 8.62 0.43 2.89e-16 Eye color traits; CRC cis rs7705042 0.826 rs6883827 chr5:141504991 A/G cg08523384 chr5:141488047 NDFIP1 -0.33 -5.85 -0.31 1.19e-8 Asthma; CRC trans rs11098499 0.588 rs2389874 chr4:120554991 A/G cg25214090 chr10:38739885 LOC399744 -0.52 -8.33 -0.42 2.22e-15 Corneal astigmatism; CRC cis rs881375 1.000 rs6478484 chr9:123652380 T/C cg00246817 chr9:123691163 NA -0.47 -5.99 -0.31 5.38e-9 Rheumatoid arthritis; CRC cis rs2075371 0.547 rs12666682 chr7:134021784 C/A cg02659138 chr7:134003124 SLC35B4 0.36 5.89 0.31 9.4e-9 Mean platelet volume; CRC cis rs16867321 0.806 rs16867314 chr2:181336471 C/A cg23363182 chr2:181467187 NA -0.52 -6.14 -0.32 2.31e-9 Obesity; CRC cis rs7177699 0.557 rs7403593 chr15:79111962 A/G cg15571903 chr15:79123663 NA -0.31 -6.08 -0.32 3.34e-9 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; CRC cis rs6589219 0.954 rs10789823 chr11:111172403 T/C cg25129781 chr11:111156908 C11orf53 -0.32 -5.7 -0.3 2.62e-8 Colorectal cancer; CRC cis rs863345 0.604 rs11265021 chr1:158511810 A/T cg12129480 chr1:158549410 OR10X1 0.29 6.32 0.33 8.33e-10 Pneumococcal bacteremia; CRC cis rs4862750 0.957 rs2375916 chr4:187903923 A/G cg10295955 chr4:187884368 NA -1.06 -25.5 -0.81 6.2e-80 Lobe attachment (rater-scored or self-reported); CRC cis rs12024301 0.557 rs78730917 chr1:183609966 G/A cg11505048 chr1:183622726 RGL1;APOBEC4 0.81 7.0 0.36 1.42e-11 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs10504073 0.506 rs7007271 chr8:49941897 T/C cg00325661 chr8:49890786 NA 0.58 10.43 0.5 3.29e-22 Blood metabolite ratios; CRC cis rs919433 0.889 rs787995 chr2:198216853 T/G cg10820045 chr2:198174542 NA 0.47 8.46 0.42 8.94e-16 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC cis rs11864453 0.826 rs8062041 chr16:72088964 C/T cg23815491 chr16:72088622 HP 0.62 9.56 0.47 2.82e-19 Fibrinogen levels; CRC cis rs2742417 1.000 rs2673058 chr3:45735618 A/C cg04837898 chr3:45731254 SACM1L -0.34 -5.63 -0.3 3.95e-8 Response to anti-depressant treatment in major depressive disorder; CRC cis rs9879311 0.966 rs7619385 chr3:10414909 G/A cg11030744 chr3:10328490 GHRL;GHRLOS 0.36 5.63 0.3 3.89e-8 Schizophrenia;Autism spectrum disorder or schizophrenia; CRC cis rs11098499 0.955 rs35916640 chr4:120155852 T/C cg24375607 chr4:120327624 NA 0.44 6.86 0.35 3.46e-11 Corneal astigmatism; CRC cis rs4731207 0.565 rs7777126 chr7:124599742 G/A cg23710748 chr7:124431027 NA -0.38 -6.08 -0.32 3.35e-9 Cutaneous malignant melanoma; CRC cis rs11758351 0.660 rs77130538 chr6:26210723 T/C cg08260959 chr6:26240920 HIST1H4F -0.36 -5.74 -0.3 2.16e-8 Gout;Renal underexcretion gout; CRC cis rs853679 0.517 rs17774663 chr6:28120898 G/A cg12963246 chr6:28129442 ZNF389 0.49 5.7 0.3 2.71e-8 Depression; CRC cis rs6089584 0.888 rs6061983 chr20:60621202 T/C cg13770153 chr20:60521292 NA -0.58 -8.77 -0.44 9.45e-17 Body mass index; CRC cis rs891088 0.626 rs12982656 chr19:7194609 C/T cg00428638 chr19:7224713 INSR -0.63 -7.75 -0.39 1.18e-13 Hip circumference adjusted for BMI;Height; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg20988798 chr7:75677766 MDH2;STYXL1 0.45 6.53 0.34 2.49e-10 Response to antipsychotic treatment; CRC cis rs1799949 1.000 rs12944430 chr17:41330820 C/G cg05368731 chr17:41323189 NBR1 0.65 9.54 0.47 3.3e-19 Menopause (age at onset); CRC cis rs10876993 0.928 rs1689586 chr12:58079586 A/T cg15848620 chr12:58087721 OS9 -0.65 -9.21 -0.45 3.84e-18 Celiac disease or Rheumatoid arthritis; CRC cis rs972578 0.776 rs3827363 chr22:43327587 G/A cg01576275 chr22:43409880 NA -0.36 -5.77 -0.3 1.83e-8 Mean platelet volume; CRC cis rs1030268 0.620 rs2160746 chr7:133478204 G/C cg10665199 chr7:133106180 EXOC4 0.54 6.1 0.32 2.93e-9 Intelligence (multi-trait analysis); CRC cis rs394563 0.591 rs237016 chr6:149744859 T/C cg16235748 chr6:149772707 ZC3H12D -0.36 -6.63 -0.34 1.38e-10 Dupuytren's disease; CRC cis rs8141529 0.711 rs5752797 chr22:29179998 C/T cg15103426 chr22:29168792 CCDC117 0.48 5.89 0.31 9.46e-9 Lymphocyte counts; CRC cis rs6502050 0.805 rs8082653 chr17:80162382 G/A cg02741985 chr17:80059408 CCDC57 0.44 7.33 0.37 1.76e-12 Life satisfaction; CRC cis rs11122272 0.735 rs2790877 chr1:231535427 A/G cg06096015 chr1:231504339 EGLN1 0.41 6.11 0.32 2.88e-9 Hemoglobin concentration; CRC cis rs72945132 0.882 rs17853270 chr11:70200529 C/T cg14191688 chr11:70257035 CTTN 0.42 5.77 0.3 1.84e-8 Coronary artery disease; CRC cis rs1976403 0.633 rs1780324 chr1:21821757 A/G cg17800788 chr1:21766015 NBPF3 0.39 6.6 0.34 1.67e-10 Liver enzyme levels (alkaline phosphatase); CRC trans rs459571 0.959 rs392134 chr9:136909008 G/A cg15028160 chr19:49622717 PPFIA3;C19orf73 -0.54 -6.61 -0.34 1.53e-10 Platelet distribution width; CRC cis rs514406 0.792 rs1242201 chr1:53344748 G/A cg08859206 chr1:53392774 SCP2 -0.59 -9.62 -0.47 1.88e-19 Monocyte count; CRC cis rs13108904 0.935 rs1732100 chr4:1281761 C/T cg16405210 chr4:1374714 KIAA1530 0.43 6.2 0.32 1.65e-9 Obesity-related traits; CRC cis rs11212617 0.967 rs3781869 chr11:108059000 T/C cg14761454 chr11:108092087 ATM;NPAT 0.4 5.89 0.31 9.49e-9 Response to metformin in type 2 diabetes (glycemic); CRC cis rs7306456 0.623 rs10902513 chr12:132693487 A/G cg02410480 chr12:132819930 GALNT9 -0.35 -5.85 -0.31 1.2e-8 Anti-saccade response; CRC cis rs8077889 0.869 rs11713 chr17:41845824 A/G cg26893861 chr17:41843967 DUSP3 -0.88 -11.73 -0.54 8.51e-27 Triglycerides; CRC cis rs4665809 0.590 rs7260 chr2:26413917 C/T cg04944784 chr2:26401820 FAM59B -0.81 -10.79 -0.51 1.91e-23 Gut microbiome composition (summer); CRC cis rs4727027 0.901 rs4727017 chr7:148822062 A/G cg23583168 chr7:148888333 NA -0.93 -16.32 -0.67 2.74e-44 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC cis rs9322193 0.736 rs3805750 chr6:150112201 G/A cg07701084 chr6:150067640 NUP43 0.48 6.75 0.35 6.67e-11 Lung cancer; CRC cis rs2836974 0.863 rs1065242 chr21:40567716 C/G cg11644478 chr21:40555479 PSMG1 0.81 12.33 0.56 5.83e-29 Cognitive function; CRC cis rs6691722 0.503 rs4140519 chr1:24708304 C/T cg18323236 chr1:24743029 NIPAL3 0.39 5.83 0.31 1.33e-8 Response to interferon beta in multiple sclerosis; CRC cis rs7085104 0.700 rs10786712 chr10:104596396 A/G cg23093090 chr10:104574429 C10orf26 0.37 6.01 0.31 5.05e-9 Immature fraction of reticulocytes;Schizophrenia; CRC cis rs2243480 1.000 rs60683927 chr7:65394768 T/C cg12463550 chr7:65579703 CRCP 0.63 6.04 0.32 4.17e-9 Diabetic kidney disease; CRC cis rs7927592 0.871 rs17603185 chr11:68376241 C/T cg01657329 chr11:68192670 LRP5 -0.47 -6.8 -0.35 5.05e-11 Total body bone mineral density; CRC cis rs7119 0.717 rs12898656 chr15:77807995 C/T cg27398640 chr15:77910606 LINGO1 0.43 7.22 0.37 3.74e-12 Type 2 diabetes; CRC cis rs7208859 0.623 rs56378576 chr17:29010120 C/T cg13385521 chr17:29058706 SUZ12P 0.71 7.69 0.39 1.71e-13 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs6502050 0.697 rs8078634 chr17:80126208 C/T cg02741985 chr17:80059408 CCDC57 0.44 7.2 0.37 4.08e-12 Life satisfaction; CRC cis rs13108904 0.901 rs1316393 chr4:1315619 A/G cg16405210 chr4:1374714 KIAA1530 0.43 6.01 0.31 4.87e-9 Obesity-related traits; CRC cis rs12586317 0.620 rs2295104 chr14:35579927 A/G cg16230307 chr14:35515116 FAM177A1 -0.85 -10.62 -0.51 7.59e-23 Psoriasis; CRC cis rs6860806 0.507 rs273917 chr5:131659618 A/G cg04518342 chr5:131593106 PDLIM4 0.44 7.12 0.37 6.71e-12 Breast cancer; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg25485084 chr12:118809325 TAOK3 0.44 6.03 0.32 4.52e-9 Thyroid stimulating hormone; CRC trans rs1997103 1.000 rs9649781 chr7:55411809 A/G cg20935933 chr6:143382018 AIG1 0.53 6.74 0.35 6.96e-11 QRS interval (sulfonylurea treatment interaction); CRC trans rs8002861 0.875 rs12872943 chr13:44410553 G/A cg17145862 chr1:211918768 LPGAT1 -0.69 -12.52 -0.57 1.09e-29 Leprosy; CRC cis rs2857891 0.909 rs17191140 chr11:6944283 G/A cg22096450 chr11:6947773 ZNF215 0.6 6.14 0.32 2.41e-9 Response to cytadine analogues (cytosine arabinoside); CRC cis rs7786808 0.552 rs35809824 chr7:158185067 C/T cg15440763 chr7:158190612 PTPRN2 0.56 8.97 0.44 2.33e-17 Obesity-related traits; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg01626569 chr16:20911881 LYRM1;DCUN1D3 0.41 6.48 0.34 3.27e-10 Liver disease severity in Alagille syndrome; CRC cis rs56114371 0.568 rs200468 chr6:27757855 C/G cg26587870 chr6:27730563 NA -0.48 -6.54 -0.34 2.3e-10 Breast cancer; CRC cis rs9322193 0.923 rs9371207 chr6:150179223 A/G cg00933542 chr6:150070202 PCMT1 0.32 6.2 0.32 1.65e-9 Lung cancer; CRC cis rs2032447 0.702 rs199753 chr6:26001888 G/A cg04800585 chr6:26043546 HIST1H2BB 0.6 8.88 0.44 4.45e-17 Intelligence (multi-trait analysis); CRC cis rs10540 1.000 rs12786555 chr11:506229 C/T cg03352830 chr11:487213 PTDSS2 0.67 7.71 0.39 1.48e-13 Body mass index; CRC cis rs6860806 0.661 rs6871350 chr5:131580220 A/G cg02033258 chr5:131593261 PDLIM4 0.4 7.5 0.38 6.11e-13 Breast cancer; CRC cis rs875971 0.861 rs801215 chr7:66011938 A/T cg12463550 chr7:65579703 CRCP -0.47 -6.41 -0.33 5.14e-10 Aortic root size; CRC cis rs798766 1.000 rs7682402 chr4:1743343 G/A cg05874882 chr4:1763078 NA -0.39 -7.16 -0.37 5.26e-12 Bladder cancer;Urinary bladder cancer; CRC trans rs2303319 0.504 rs12470830 chr2:162429996 C/T cg14875682 chr5:52083620 ITGA1;PELO -0.8 -6.48 -0.34 3.35e-10 Cognitive function; CRC cis rs7945705 0.902 rs1560569 chr11:8939887 C/T cg21881798 chr11:8931708 C11orf17;ST5 -0.69 -11.01 -0.52 3.26e-24 Hemoglobin concentration; CRC cis rs1005277 0.602 rs1740743 chr10:38519222 C/T cg25517755 chr10:38738941 LOC399744 -0.41 -5.92 -0.31 8.23e-9 Extrinsic epigenetic age acceleration; CRC cis rs1109861 0.663 rs658469 chr10:11221366 C/T cg24910943 chr10:11206320 CUGBP2 -0.34 -9.54 -0.47 3.32e-19 Urinary albumin-to-creatinine ratio; CRC cis rs13394619 0.655 rs7578132 chr2:11718858 C/T cg07314298 chr2:11723111 GREB1 -0.41 -6.92 -0.36 2.35e-11 Endometriosis; CRC cis rs6088580 0.634 rs6120642 chr20:33012531 A/G cg08999081 chr20:33150536 PIGU 0.61 11.47 0.53 7.56e-26 Glomerular filtration rate (creatinine); CRC cis rs3018066 0.692 rs7658011 chr4:106961023 A/G cg01869342 chr4:106983673 TBCK 0.5 6.42 0.33 4.8e-10 Cancer; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg12592908 chr6:36954170 MTCH1 0.35 5.97 0.31 6.11e-9 Liver disease severity in Alagille syndrome; CRC cis rs477895 0.653 rs66648159 chr11:63899429 G/A cg23719950 chr11:63933701 MACROD1 -0.65 -8.25 -0.41 3.82e-15 Mean platelet volume; CRC cis rs13064411 0.696 rs6768979 chr3:113204149 G/A cg10517650 chr3:113235015 CCDC52 -0.41 -7.18 -0.37 4.55e-12 Response to simvastatin treatment (PCSK9 protein level change); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg26264429 chr14:45603676 FKBP3;FANCM 0.39 5.97 0.31 5.99e-9 Intelligence (multi-trait analysis); CRC cis rs9388451 0.839 rs3799709 chr6:126078361 A/G cg10911889 chr6:126070802 HEY2 0.38 5.75 0.3 2.05e-8 Brugada syndrome; CRC cis rs2882667 0.861 rs10043676 chr5:138389561 C/T cg04439458 chr5:138467593 SIL1 -0.34 -6.13 -0.32 2.45e-9 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs4713118 0.513 rs149954 chr6:28035246 G/A cg12172441 chr6:28176163 NA 0.51 7.1 0.36 7.58e-12 Parkinson's disease; CRC cis rs16867321 0.950 rs12472841 chr2:181491840 C/A cg23363182 chr2:181467187 NA -0.53 -6.88 -0.35 2.94e-11 Obesity; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg25898425 chr17:7137333 DVL2 0.41 6.02 0.31 4.62e-9 Intelligence (multi-trait analysis); CRC cis rs11148252 0.904 rs7990581 chr13:53019433 A/G cg02158880 chr13:53174818 NA 0.48 7.18 0.37 4.8e-12 Lewy body disease; CRC cis rs72615157 0.612 rs7786505 chr7:99817585 G/T cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.46 5.78 0.3 1.77e-8 Lung function (FEV1/FVC); CRC cis rs11650494 0.908 rs79768864 chr17:47446968 C/A cg08112188 chr17:47440006 ZNF652 1.25 11.73 0.54 8.73e-27 Prostate cancer; CRC cis rs9322193 0.962 rs9397022 chr6:150133188 C/T cg07701084 chr6:150067640 NUP43 0.47 6.69 0.35 9.6e-11 Lung cancer; CRC cis rs2239547 0.523 rs6803486 chr3:53098209 T/A cg11645453 chr3:52864694 ITIH4 0.51 8.46 0.42 9.04e-16 Schizophrenia; CRC cis rs7618915 0.570 rs11714088 chr3:52758942 A/C cg05573699 chr3:52720067 GNL3;PBRM1 -0.47 -6.68 -0.35 1.03e-10 Bipolar disorder; CRC cis rs7666738 0.791 rs1593571 chr4:98963763 T/C cg05340658 chr4:99064831 C4orf37 0.61 9.45 0.46 6.55e-19 Colonoscopy-negative controls vs population controls; CRC cis rs13108904 0.560 rs11247994 chr4:1343720 G/A cg15763984 chr4:1342303 KIAA1530 0.47 7.42 0.38 9.84e-13 Obesity-related traits; CRC cis rs11190604 1.000 rs11190595 chr10:102291761 T/C cg16342193 chr10:102329863 NA -0.36 -5.94 -0.31 7.21e-9 Palmitoleic acid (16:1n-7) levels; CRC cis rs1552244 1.000 rs7637888 chr3:10080722 T/C cg18598329 chr3:10140678 FANCD2;C3orf24 -0.89 -11.87 -0.55 2.69e-27 Alzheimer's disease; CRC cis rs6724607 1.000 rs4853513 chr2:191479455 C/T cg27211696 chr2:191398769 TMEM194B -0.4 -5.99 -0.31 5.36e-9 Pulse pressure; CRC cis rs6424115 0.830 rs3003333 chr1:24194014 A/T cg10978503 chr1:24200527 CNR2 -0.55 -10.05 -0.48 6.73e-21 Immature fraction of reticulocytes; CRC cis rs561341 0.739 rs1978116 chr17:30220978 A/C cg12193833 chr17:30244370 NA -0.45 -6.19 -0.32 1.77e-9 Hip circumference adjusted for BMI; CRC trans rs9341835 0.709 rs9359467 chr6:64154975 G/C cg13657004 chr13:50234944 EBPL -0.37 -6.18 -0.32 1.92e-9 Schizophrenia; CRC cis rs9372498 0.706 rs9489396 chr6:118761703 A/C cg18833306 chr6:118973337 C6orf204 0.44 5.74 0.3 2.12e-8 Diastolic blood pressure; CRC cis rs7224737 1.000 rs35184688 chr17:40272406 G/C cg02450064 chr17:40260053 DHX58 -0.43 -6.13 -0.32 2.55e-9 Fibrinogen levels; CRC cis rs7044106 0.791 rs10984997 chr9:123481206 T/A cg09586646 chr9:123605570 PSMD5;LOC253039 0.61 8.61 0.43 3.07e-16 Hip circumference adjusted for BMI; CRC cis rs11212617 0.967 rs227076 chr11:108218905 T/C cg01991180 chr11:108092276 ATM;NPAT 0.41 6.02 0.31 4.79e-9 Response to metformin in type 2 diabetes (glycemic); CRC trans rs66887589 0.934 rs56843000 chr4:120516597 T/C cg25214090 chr10:38739885 LOC399744 -0.41 -6.38 -0.33 6.13e-10 Diastolic blood pressure; CRC cis rs6951245 0.872 rs76713558 chr7:1095866 A/G cg20603222 chr7:1096387 C7orf50;GPR146 -0.72 -8.67 -0.43 1.96e-16 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs995000 0.839 rs1168010 chr1:62943979 G/A cg19896129 chr1:63156450 NA -0.39 -6.02 -0.31 4.78e-9 Triglyceride levels; CRC trans rs12495832 0.778 rs12635568 chr3:147938960 A/G cg10221266 chr7:153579447 NA 0.53 5.97 0.31 6.06e-9 Chin dimples; CRC cis rs7618501 0.601 rs2624825 chr3:50154989 G/A cg05623727 chr3:50126028 RBM5 -0.43 -7.33 -0.37 1.84e-12 Intelligence (multi-trait analysis); CRC cis rs7843479 0.601 rs7220 chr8:21863290 G/A cg16476235 chr8:21771668 DOK2 0.4 6.73 0.35 7.42e-11 Mean corpuscular volume; CRC cis rs7312774 0.618 rs4964510 chr12:107357251 A/G cg16260113 chr12:107380972 MTERFD3 1.0 9.37 0.46 1.18e-18 Severe influenza A (H1N1) infection; CRC trans rs2228479 1.000 rs2228479 chr16:89985940 G/A cg21302420 chr1:112162376 RAP1A 0.69 6.15 0.32 2.28e-9 Skin colour saturation; CRC cis rs2153535 0.580 rs1120392 chr6:8487053 C/A cg07606381 chr6:8435919 SLC35B3 0.68 10.89 0.51 8.84e-24 Motion sickness; CRC cis rs77861329 1.000 rs9817653 chr3:52148233 T/G cg08692210 chr3:52188851 WDR51A 0.85 7.76 0.39 1.05e-13 Macrophage inflammatory protein 1b levels; CRC cis rs7618915 0.621 rs6788993 chr3:52605136 T/C cg05573699 chr3:52720067 GNL3;PBRM1 -0.47 -6.79 -0.35 5.35e-11 Bipolar disorder; CRC cis rs2075371 0.966 rs1619682 chr7:133996703 T/G cg02659138 chr7:134003124 SLC35B4 0.42 7.35 0.38 1.57e-12 Mean platelet volume; CRC cis rs7113874 0.569 rs1446463 chr11:8566329 G/A cg17679104 chr11:8615758 STK33 -0.36 -6.01 -0.31 4.87e-9 Body mass index in physically active individuals;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs4713118 0.513 rs149975 chr6:27986340 G/A cg15845792 chr6:28175446 NA 0.78 11.44 0.53 9.8e-26 Parkinson's disease; CRC cis rs4867766 0.585 rs6878032 chr5:173950070 A/G cg20434911 chr5:173954559 NA 0.64 7.09 0.36 8e-12 Stroke; CRC cis rs28386778 0.830 rs2584625 chr17:61903445 G/C cg06601766 chr17:61851465 DDX42;CCDC47 0.45 6.14 0.32 2.33e-9 Prudent dietary pattern; CRC cis rs875971 0.862 rs7782704 chr7:65805366 G/A cg11764359 chr7:65958608 NA -0.61 -9.44 -0.46 6.9e-19 Aortic root size; CRC trans rs17685 0.775 rs11761172 chr7:75761547 C/T cg19862616 chr7:65841803 NCRNA00174 0.99 18.11 0.71 2.51e-51 Coffee consumption;Coffee consumption (cups per day); CRC cis rs644799 0.965 rs10831430 chr11:95509638 T/C cg25622487 chr11:95524042 FAM76B;CEP57 0.75 11.46 0.53 8.54e-26 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs6582630 0.537 rs1851124 chr12:38516404 G/A cg26384229 chr12:38710491 ALG10B 0.71 10.1 0.49 4.6e-21 Drug-induced liver injury (flucloxacillin); CRC cis rs477895 0.653 rs34089806 chr11:63887987 C/T cg19465662 chr11:63993652 NUDT22;TRPT1 0.73 9.05 0.45 1.29e-17 Mean platelet volume; CRC trans rs8123881 0.733 rs7268466 chr20:15810676 C/T cg15383719 chr1:100316030 AGL 0.55 6.22 0.32 1.48e-9 Body mass index; CRC cis rs2635047 0.638 rs2571010 chr18:44652130 A/G cg23996704 chr18:44553084 KATNAL2 -0.29 -5.66 -0.3 3.29e-8 Educational attainment; CRC cis rs7103648 1.000 rs12292911 chr11:47449072 C/T cg20307385 chr11:47447363 PSMC3 0.99 18.01 0.7 5.77e-51 Diastolic blood pressure;Systolic blood pressure; CRC cis rs3859192 0.561 rs34453912 chr17:38180352 T/A cg17467752 chr17:38218738 THRA -0.51 -7.53 -0.38 4.88e-13 White blood cell count; CRC cis rs7044106 0.762 rs3903886 chr9:123383646 A/G cg09586646 chr9:123605570 PSMD5;LOC253039 -0.61 -9.19 -0.45 4.58e-18 Hip circumference adjusted for BMI; CRC cis rs561341 1.000 rs548957 chr17:30302411 G/A cg19193384 chr17:30244184 NA -0.65 -7.49 -0.38 6.27e-13 Hip circumference adjusted for BMI; CRC cis rs6582630 0.555 rs10880611 chr12:38509316 C/G cg13010199 chr12:38710504 ALG10B 0.48 6.46 0.34 3.84e-10 Drug-induced liver injury (flucloxacillin); CRC cis rs798554 0.721 rs2527680 chr7:2892361 C/T cg09658497 chr7:2847517 GNA12 -0.42 -5.65 -0.3 3.55e-8 Height; CRC cis rs10751667 0.666 rs10902241 chr11:949129 G/A cg01483505 chr11:975446 AP2A2 0.45 7.39 0.38 1.24e-12 Alzheimer's disease (late onset); CRC cis rs2549003 0.933 rs3846731 chr5:131814264 T/C cg02551604 chr5:131831745 NA -0.54 -8.38 -0.42 1.58e-15 Asthma (sex interaction); CRC cis rs9522267 0.559 rs9522300 chr13:112236668 C/G cg26182253 chr13:112236782 NA 0.31 6.33 0.33 7.97e-10 Hepatitis; CRC cis rs1448094 0.511 rs17279240 chr12:86162550 A/T cg02569458 chr12:86230093 RASSF9 0.47 7.78 0.39 9.77e-14 Major depressive disorder; CRC cis rs1129187 0.755 rs9462855 chr6:42925936 G/C cg10862848 chr6:42927986 GNMT -0.38 -9.07 -0.45 1.11e-17 Alzheimer's disease in APOE e4+ carriers; CRC cis rs10865541 0.902 rs7558487 chr2:3425514 G/C cg22182287 chr2:3452347 TTC15 0.39 6.25 0.33 1.24e-9 Obesity-related traits; CRC cis rs12762955 0.507 rs7070724 chr10:1040138 C/T cg19847866 chr10:1019161 NA 0.42 6.13 0.32 2.53e-9 Response to angiotensin II receptor blocker therapy; CRC cis rs1158570 0.500 rs2670890 chr8:131314923 G/A cg26053073 chr8:131455383 NA 0.42 6.27 0.33 1.11e-9 Platelet count; CRC cis rs6952808 0.542 rs10243920 chr7:1950385 G/A cg00106254 chr7:1943704 MAD1L1 -0.37 -5.84 -0.31 1.22e-8 Bipolar disorder and schizophrenia; CRC cis rs12760731 0.565 rs10913519 chr1:178196094 A/T cg00404053 chr1:178313656 RASAL2 1.11 11.45 0.53 8.75e-26 Obesity-related traits; CRC cis rs2204008 0.569 rs11495449 chr12:37995753 C/T cg26384229 chr12:38710491 ALG10B 0.68 8.93 0.44 3.1e-17 Bladder cancer; CRC cis rs796364 0.951 rs281776 chr2:200834282 T/G cg25936922 chr2:200820526 C2orf60;C2orf47 0.72 7.85 0.4 5.87e-14 Schizophrenia; CRC cis rs6545883 0.931 rs778768 chr2:61790289 C/G cg15711740 chr2:61764176 XPO1 -0.53 -7.19 -0.37 4.51e-12 Tuberculosis; CRC cis rs172166 0.652 rs476167 chr6:28065888 T/C cg15845792 chr6:28175446 NA 0.79 11.71 0.54 1.05e-26 Cardiac Troponin-T levels; CRC cis rs35110281 0.712 rs167930 chr21:44946625 G/A cg01579765 chr21:45077557 HSF2BP -0.37 -6.91 -0.36 2.54e-11 Mean corpuscular volume; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg08862778 chr1:11322643 MTOR 0.45 6.5 0.34 2.93e-10 Response to antipsychotic treatment; CRC cis rs7264396 0.635 rs6058365 chr20:34508092 C/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.62 -10.13 -0.49 3.57e-21 Total cholesterol levels; CRC trans rs1814175 0.647 rs28456013 chr11:50047629 T/C cg11707556 chr5:10655725 ANKRD33B -0.38 -7.09 -0.36 8.46e-12 Height; CRC cis rs2180341 0.960 rs9398840 chr6:127669744 G/A cg27446573 chr6:127587934 RNF146 0.97 13.77 0.6 2.17e-34 Breast cancer; CRC cis rs7959452 0.558 rs1478464 chr12:69779789 G/C cg14784868 chr12:69753453 YEATS4 0.79 13.08 0.58 8.99e-32 Blood protein levels; CRC cis rs6831352 0.959 rs6532795 chr4:100042221 C/T cg12011299 chr4:100065546 ADH4 -0.54 -11.29 -0.53 3.41e-25 Alcohol dependence; CRC cis rs12586317 0.531 rs60049741 chr14:35719842 G/A cg07166546 chr14:35805898 NA -0.3 -5.84 -0.31 1.27e-8 Psoriasis; CRC cis rs4654899 0.758 rs6697284 chr1:21295599 G/A cg02927042 chr1:21476669 EIF4G3 -0.4 -6.27 -0.33 1.14e-9 Superior frontal gyrus grey matter volume; CRC cis rs9318086 0.648 rs7330140 chr13:24473074 A/T cg25267304 chr13:24462978 PCOTH;MIPEP 0.65 10.41 0.5 3.96e-22 Myopia (pathological); CRC cis rs6754311 0.731 rs2236783 chr2:136594158 G/A cg15123519 chr2:136567270 LCT 0.33 6.41 0.33 5.07e-10 Mosquito bite size; CRC cis rs651907 0.557 rs11925001 chr3:101373966 C/T cg12386194 chr3:101231763 SENP7 0.49 7.11 0.36 7.34e-12 Colorectal cancer; CRC cis rs17601876 0.807 rs10519299 chr15:51551346 C/G cg19946085 chr15:51559439 CYP19A1 -0.32 -6.55 -0.34 2.28e-10 Estrone/androstenedione ratio in resected early stage-receptor positive breast cancer; CRC cis rs1322512 1.000 rs7744697 chr6:152948986 G/A cg03415253 chr6:152958462 SYNE1 -0.42 -6.43 -0.33 4.53e-10 Tonometry; CRC cis rs597539 0.652 rs686877 chr11:68637169 G/A cg06112835 chr11:68658793 MRPL21 0.43 6.88 0.35 3.11e-11 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs7618915 0.501 rs35526119 chr3:52749334 C/T cg08222913 chr3:52553049 STAB1 -0.33 -6.12 -0.32 2.64e-9 Bipolar disorder; CRC cis rs72615157 0.634 rs74774557 chr7:99810425 A/G cg19337854 chr7:99768885 GPC2 0.48 6.38 0.33 6e-10 Lung function (FEV1/FVC); CRC cis rs6951245 0.706 rs28685743 chr7:1197736 C/T cg26224354 chr7:1096374 C7orf50;GPR146 -0.77 -9.96 -0.48 1.3e-20 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs6831352 0.918 rs13133647 chr4:100058727 C/T cg13256891 chr4:100009986 ADH5 -0.66 -8.89 -0.44 4.04e-17 Alcohol dependence; CRC cis rs13191362 0.935 rs34540135 chr6:162934351 A/G cg06582575 chr6:163149167 PACRG;PARK2 0.77 9.25 0.45 2.88e-18 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs6952808 1.000 rs6952808 chr7:1886535 C/G cg00106254 chr7:1943704 MAD1L1 -0.39 -5.77 -0.3 1.81e-8 Bipolar disorder and schizophrenia; CRC cis rs6586163 0.527 rs3824730 chr10:90752128 A/T cg13456138 chr10:90753195 FAS 0.42 5.87 0.31 1.07e-8 Chronic lymphocytic leukemia; CRC cis rs8031584 0.560 rs1056118 chr15:31203786 G/A cg08704250 chr15:31115839 NA 0.32 5.83 0.31 1.32e-8 Huntington's disease progression; CRC cis rs763014 0.966 rs4984904 chr16:680809 C/G cg07343612 chr16:622815 PIGQ -0.79 -13.02 -0.58 1.52e-31 Height; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg14184786 chr14:94547643 IFI27L1;DDX24 0.46 6.01 0.31 4.89e-9 Thyroid stimulating hormone; CRC cis rs6831352 0.918 rs17218239 chr4:100057020 G/A cg12011299 chr4:100065546 ADH4 -0.49 -9.27 -0.45 2.61e-18 Alcohol dependence; CRC cis rs7412746 0.658 rs3843843 chr1:150918084 C/T cg17724175 chr1:150552817 MCL1 0.44 6.59 0.34 1.73e-10 Melanoma; CRC trans rs1005277 0.541 rs2263163 chr10:38389887 G/A cg27523141 chr10:43048294 ZNF37B 0.49 7.14 0.37 6.19e-12 Extrinsic epigenetic age acceleration; CRC cis rs4409675 0.576 rs7536088 chr1:28234325 A/G cg23691781 chr1:28212827 C1orf38 0.31 6.56 0.34 2.1e-10 Corneal astigmatism; CRC cis rs597539 0.652 rs544370 chr11:68653232 C/T cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.89 16.22 0.67 6.93e-44 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs2404602 0.716 rs12441247 chr15:76812316 T/C cg22467129 chr15:76604101 ETFA -0.45 -7.44 -0.38 9.1e-13 Blood metabolite levels; CRC cis rs2408955 0.522 rs11168408 chr12:48498327 G/A cg24011408 chr12:48396354 COL2A1 -0.45 -6.4 -0.33 5.48e-10 Glycated hemoglobin levels; CRC cis rs2243480 1.000 rs160634 chr7:65528664 C/T cg12463550 chr7:65579703 CRCP -0.59 -6.29 -0.33 1.04e-9 Diabetic kidney disease; CRC cis rs6502050 0.835 rs4789724 chr17:80150546 G/A cg09264619 chr17:80180166 NA -0.35 -5.81 -0.31 1.48e-8 Life satisfaction; CRC cis rs12347191 0.500 rs1465965 chr9:100620326 C/T cg13688889 chr9:100608707 NA -0.48 -6.09 -0.32 3.2e-9 Orofacial clefts; CRC cis rs6502050 0.835 rs62080004 chr17:80079079 C/T cg19223190 chr17:80058835 NA -0.39 -6.09 -0.32 3.17e-9 Life satisfaction; CRC cis rs12143943 0.866 rs12032618 chr1:204532659 C/T cg17419461 chr1:204415978 PIK3C2B 0.4 6.28 0.33 1.05e-9 Cognitive performance; CRC trans rs732528 1.000 rs2847577 chr18:48364819 A/G cg15540507 chr19:3676403 PIP5K1C 0.46 6.11 0.32 2.84e-9 Entorhinal cortical thickness; CRC cis rs3743266 0.613 rs4775273 chr15:60738566 T/G cg21667061 chr15:60772094 NARG2 -0.28 -5.73 -0.3 2.23e-8 Menarche (age at onset); CRC cis rs7072216 0.922 rs4539242 chr10:100148058 T/C cg26618903 chr10:100175079 PYROXD2 -0.39 -6.62 -0.34 1.46e-10 Metabolite levels; CRC cis rs16852403 0.517 rs2902217 chr1:178248162 T/C cg00404053 chr1:178313656 RASAL2 0.48 6.12 0.32 2.6e-9 Childhood ear infection; CRC cis rs10504229 0.683 rs77548248 chr8:58117542 G/A cg02290350 chr8:58132656 NA -0.57 -7.91 -0.4 4.05e-14 Developmental language disorder (linguistic errors); CRC cis rs7725052 0.609 rs4507534 chr5:40453033 C/T cg09067459 chr5:40385259 NA -0.4 -6.67 -0.35 1.09e-10 Pediatric autoimmune diseases; CRC cis rs4253772 0.591 rs6008384 chr22:46655948 T/C cg24881330 chr22:46731750 TRMU 0.59 7.03 0.36 1.24e-11 LDL cholesterol;Cholesterol, total; CRC cis rs311392 0.526 rs167474 chr8:55101321 A/C cg06042504 chr8:55087323 NA -0.36 -5.67 -0.3 3.08e-8 Pelvic organ prolapse (moderate/severe); CRC trans rs2470578 0.716 rs2733514 chr3:17323931 A/G cg04479987 chr5:180649488 TRIM41 -0.43 -6.17 -0.32 2.01e-9 Schizophrenia; CRC cis rs7617773 0.817 rs3729577 chr3:48228994 A/C cg11946769 chr3:48343235 NME6 0.72 9.69 0.47 1.05e-19 Coronary artery disease; CRC cis rs9287719 0.601 rs12995465 chr2:10716828 G/A cg00105475 chr2:10696890 NA 0.48 7.27 0.37 2.72e-12 Prostate cancer; CRC cis rs1005277 0.579 rs2505198 chr10:38393183 A/C cg25517755 chr10:38738941 LOC399744 -0.41 -6.09 -0.32 3.13e-9 Extrinsic epigenetic age acceleration; CRC cis rs77972916 0.518 rs55877805 chr2:43557597 G/C cg06169590 chr2:43455088 ZFP36L2;LOC100129726 -0.63 -5.93 -0.31 7.64e-9 Granulocyte percentage of myeloid white cells; CRC cis rs2153535 0.580 rs1414351 chr6:8476634 T/C cg07606381 chr6:8435919 SLC35B3 0.68 10.9 0.51 8.26e-24 Motion sickness; CRC cis rs7223966 1.000 rs28463311 chr17:61919643 C/T cg23090583 chr17:61904693 PSMC5;FTSJ3 0.58 7.0 0.36 1.44e-11 Hip circumference adjusted for BMI;Body mass index; CRC cis rs10876993 0.928 rs2169988 chr12:58071165 G/A cg18357645 chr12:58087776 OS9 0.6 8.49 0.42 7.08e-16 Celiac disease or Rheumatoid arthritis; CRC cis rs3026101 0.671 rs2407 chr17:5289028 G/A cg25236894 chr17:5323110 RPAIN;NUP88 0.39 6.4 0.33 5.43e-10 Body mass index; CRC cis rs4665809 0.838 rs2243834 chr2:26357748 A/C cg27170947 chr2:26402098 FAM59B 0.43 5.72 0.3 2.36e-8 Gut microbiome composition (summer); CRC cis rs57994353 0.632 rs68142670 chr9:139324573 T/C cg13611204 chr9:139324423 INPP5E -0.45 -6.35 -0.33 7.3e-10 Eosinophil counts;Cutaneous squamous cell carcinoma; CRC cis rs2842992 1.000 rs2758322 chr6:160075188 G/T cg11366901 chr6:160182831 ACAT2 0.8 11.38 0.53 1.62e-25 Age-related macular degeneration (geographic atrophy); CRC cis rs7618915 0.501 rs7611731 chr3:52692721 T/C cg15147215 chr3:52552868 STAB1 -0.64 -11.07 -0.52 1.98e-24 Bipolar disorder; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg21149286 chr12:65153070 GNS 0.41 6.33 0.33 8.06e-10 Intelligence (multi-trait analysis); CRC cis rs863345 0.604 rs7518808 chr1:158491820 G/A cg12129480 chr1:158549410 OR10X1 -0.3 -6.25 -0.33 1.25e-9 Pneumococcal bacteremia; CRC trans rs1005277 0.522 rs1208767 chr10:38042295 G/T cg17830980 chr10:43048298 ZNF37B -0.4 -6.24 -0.33 1.38e-9 Extrinsic epigenetic age acceleration; CRC cis rs6951245 1.000 rs11763020 chr7:1060288 C/T cg07217954 chr7:1067459 C7orf50 0.57 5.93 0.31 7.59e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs2032447 0.714 rs2051540 chr6:25947197 T/C cg03264133 chr6:25882463 NA -0.58 -8.16 -0.41 7.4e-15 Intelligence (multi-trait analysis); CRC cis rs270601 0.739 rs3900945 chr5:131592870 T/C cg12564285 chr5:131593104 PDLIM4 0.56 10.72 0.51 3.38e-23 Acylcarnitine levels; CRC cis rs2153535 0.580 rs9505457 chr6:8479142 C/T cg21535247 chr6:8435926 SLC35B3 0.49 7.38 0.38 1.3e-12 Motion sickness; CRC cis rs6681460 0.584 rs7528182 chr1:67067369 C/T cg02459107 chr1:67143332 SGIP1 0.36 6.59 0.34 1.77e-10 Presence of antiphospholipid antibodies; CRC cis rs12760731 0.720 rs10798606 chr1:178372965 G/A cg00404053 chr1:178313656 RASAL2 0.87 10.43 0.5 3.29e-22 Obesity-related traits; CRC cis rs116095464 0.558 rs57335027 chr5:262907 A/G cg22857025 chr5:266934 NA -1.25 -16.78 -0.68 4.42e-46 Breast cancer; CRC cis rs534126 1.000 rs557797 chr7:142921509 T/C cg04039957 chr7:143013207 CLCN1 0.37 6.51 0.34 2.8e-10 Cancer; CRC cis rs10979 1.000 rs12212011 chr6:143894694 C/A cg25407410 chr6:143891975 LOC285740 -0.83 -13.73 -0.6 3.07e-34 Hypospadias; CRC trans rs1005277 0.579 rs2505198 chr10:38393183 A/C cg17830980 chr10:43048298 ZNF37B -0.57 -9.52 -0.46 3.76e-19 Extrinsic epigenetic age acceleration; CRC cis rs875971 0.895 rs778700 chr7:65866450 C/T cg12463550 chr7:65579703 CRCP 0.48 6.96 0.36 1.89e-11 Aortic root size; CRC cis rs2832191 0.692 rs2245734 chr21:30359965 C/T cg24692254 chr21:30365293 RNF160 0.86 16.13 0.66 1.54e-43 Dental caries; CRC cis rs2842992 0.789 rs7765490 chr6:160204326 C/T cg16489826 chr6:160211363 TCP1;MRPL18 0.49 6.41 0.33 4.98e-10 Age-related macular degeneration (geographic atrophy); CRC cis rs28386778 0.787 rs2665827 chr17:61961350 G/C cg22520471 chr17:61851767 DDX42;CCDC47 0.75 11.25 0.53 4.64e-25 Prudent dietary pattern; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg15418287 chr17:40706385 HSD17B1 0.45 6.5 0.34 2.93e-10 Response to antipsychotic treatment; CRC cis rs2992756 0.663 rs2992735 chr1:18800387 T/A cg14356550 chr1:18808102 KLHDC7A -0.4 -5.68 -0.3 3.03e-8 Breast cancer; CRC cis rs2635047 1.000 rs2684826 chr18:44679147 A/G cg19077165 chr18:44547161 KATNAL2 -0.45 -7.18 -0.37 4.78e-12 Educational attainment; CRC cis rs1577917 0.958 rs12213331 chr6:86504797 T/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.55 -6.88 -0.35 2.96e-11 Response to antipsychotic treatment; CRC cis rs4731207 0.698 rs7795492 chr7:124524131 C/T cg23710748 chr7:124431027 NA -0.37 -5.91 -0.31 8.41e-9 Cutaneous malignant melanoma; CRC cis rs4862750 0.914 rs9998558 chr4:187874691 A/G cg10295955 chr4:187884368 NA -0.99 -23.51 -0.79 1.98e-72 Lobe attachment (rater-scored or self-reported); CRC cis rs9814567 1.000 rs2177601 chr3:134245434 T/C cg06109529 chr3:134205091 CEP63;ANAPC13 0.82 12.06 0.55 5.69e-28 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs904251 0.828 rs1757178 chr6:37486310 C/T cg25019722 chr6:37503610 NA 0.48 8.92 0.44 3.21e-17 Cognitive performance; CRC cis rs72634258 0.503 rs697674 chr1:7837878 C/G cg26816564 chr1:7831052 VAMP3 0.79 9.55 0.47 3.07e-19 Inflammatory bowel disease; CRC cis rs116095464 0.558 rs10065239 chr5:275288 C/T cg22857025 chr5:266934 NA -1.16 -12.06 -0.55 5.41e-28 Breast cancer; CRC cis rs4713118 0.621 rs4713132 chr6:28034035 A/G cg18032046 chr6:28092343 ZSCAN16 -0.47 -5.6 -0.3 4.53e-8 Parkinson's disease; CRC cis rs1862618 0.853 rs252915 chr5:56121754 C/T cg20203395 chr5:56204925 C5orf35 0.65 7.93 0.4 3.54e-14 Initial pursuit acceleration; CRC cis rs9309711 0.666 rs6723126 chr2:3484500 T/C cg15541040 chr2:3486749 NA -0.52 -8.29 -0.42 2.83e-15 Neurofibrillary tangles; CRC cis rs9322817 0.625 rs2499655 chr6:105307435 G/A cg02098413 chr6:105308735 HACE1 0.43 8.54 0.43 5.22e-16 Thyroid stimulating hormone; CRC cis rs7567389 0.740 rs4536600 chr2:128002572 A/G cg06038358 chr2:128176007 PROC 0.33 5.66 0.3 3.28e-8 Self-rated health; CRC cis rs10876993 0.928 rs2640636 chr12:58077544 A/G cg18357645 chr12:58087776 OS9 0.62 8.83 0.44 6.45e-17 Celiac disease or Rheumatoid arthritis; CRC cis rs863345 0.625 rs12063360 chr1:158499494 A/C cg12129480 chr1:158549410 OR10X1 -0.3 -6.27 -0.33 1.12e-9 Pneumococcal bacteremia; CRC trans rs6499188 0.571 rs1645975 chr16:68564448 C/T cg04657470 chr2:198365150 HSPE1;HSPD1 0.57 6.78 0.35 5.72e-11 Ulcerative colitis; CRC cis rs370915 0.578 rs1367932 chr4:187776654 A/G cg12892747 chr4:187813459 NA -0.56 -8.12 -0.41 9.57e-15 Gout; CRC cis rs7666738 0.830 rs10031292 chr4:99056877 A/G cg05340658 chr4:99064831 C4orf37 0.6 9.23 0.45 3.34e-18 Colonoscopy-negative controls vs population controls; CRC trans rs7613875 0.600 rs2624826 chr3:50155468 T/G cg21665057 chr3:196295764 WDR53;FBXO45 -0.44 -6.32 -0.33 8.67e-10 Body mass index; CRC cis rs2795502 0.882 rs2744087 chr10:43340270 A/C cg20628663 chr10:43360327 NA -0.69 -10.8 -0.51 1.83e-23 Blood protein levels; CRC cis rs6903823 0.508 rs1150718 chr6:28256947 C/A cg21251018 chr6:28226885 NKAPL 0.55 9.45 0.46 6.36e-19 Pulmonary function; CRC cis rs10876993 0.784 rs10083154 chr12:58020933 G/A cg18357645 chr12:58087776 OS9 -0.51 -6.76 -0.35 6.44e-11 Celiac disease or Rheumatoid arthritis; CRC cis rs898097 0.801 rs68141193 chr17:80878816 C/T cg15664640 chr17:80829946 TBCD -0.66 -10.74 -0.51 2.8e-23 Breast cancer; CRC cis rs2836974 0.568 rs442972 chr21:40534757 C/T cg11644478 chr21:40555479 PSMG1 -0.71 -11.91 -0.55 1.95e-27 Cognitive function; CRC cis rs13256369 1.000 rs7820159 chr8:8576215 T/C cg17143192 chr8:8559678 CLDN23 0.49 6.28 0.33 1.1e-9 Obesity-related traits; CRC cis rs8180040 0.620 rs4683322 chr3:47093189 T/C cg27129171 chr3:47204927 SETD2 0.73 11.44 0.53 9.82e-26 Colorectal cancer; CRC cis rs853679 0.517 rs9393887 chr6:28059020 G/A cg02631126 chr6:28058918 ZSCAN12L1 0.29 6.05 0.32 3.85e-9 Depression; CRC cis rs12950390 0.853 rs10445375 chr17:45864314 C/T cg24803719 chr17:45855879 NA 0.3 6.77 0.35 5.96e-11 IgG glycosylation; CRC cis rs11971779 0.680 rs6963867 chr7:139059964 T/G cg07862535 chr7:139043722 LUC7L2 0.57 7.35 0.38 1.61e-12 Diisocyanate-induced asthma; CRC cis rs13108904 0.870 rs13115355 chr4:1261576 G/A cg05665937 chr4:1216051 CTBP1 0.4 5.87 0.31 1.08e-8 Obesity-related traits; CRC cis rs317689 0.513 rs317678 chr12:69692166 C/G cg22834771 chr12:69754056 YEATS4 -0.4 -5.71 -0.3 2.51e-8 Response to diuretic therapy; CRC cis rs7224737 1.000 rs9915255 chr17:40284191 C/T cg00647820 chr17:40259828 DHX58 -0.46 -6.55 -0.34 2.18e-10 Fibrinogen levels; CRC cis rs8005677 0.962 rs10130756 chr14:23396600 C/G cg25600027 chr14:23388339 RBM23 -0.51 -7.93 -0.4 3.4e-14 Cognitive ability (multi-trait analysis); CRC cis rs4862750 0.872 rs7671914 chr4:187878165 A/G cg06074448 chr4:187884817 NA -0.57 -10.62 -0.51 7.25e-23 Lobe attachment (rater-scored or self-reported); CRC cis rs798554 0.757 rs1182181 chr7:2873247 C/G cg19717773 chr7:2847554 GNA12 -0.48 -6.93 -0.36 2.2e-11 Height; CRC cis rs25422 0.938 rs62424176 chr6:118798602 T/C cg15382696 chr6:118971807 C6orf204 0.59 7.47 0.38 7.36e-13 Renal cell carcinoma; CRC trans rs2727020 0.636 rs11040368 chr11:49453602 C/A cg15704280 chr7:45808275 SEPT13 -0.92 -17.52 -0.69 5.41e-49 Coronary artery disease; CRC cis rs12477438 0.765 rs2309520 chr2:99570477 C/G cg26064155 chr2:99771622 LIPT1;TSGA10 0.62 8.64 0.43 2.53e-16 Chronic sinus infection; CRC trans rs11039798 1.000 rs7123704 chr11:48580535 G/A cg15704280 chr7:45808275 SEPT13 0.62 6.02 0.31 4.58e-9 Axial length; CRC cis rs60871478 0.786 rs12536056 chr7:831351 T/A cg13798912 chr7:905769 UNC84A -0.52 -5.84 -0.31 1.25e-8 Cerebrospinal P-tau181p levels; CRC cis rs7927771 0.756 rs10742803 chr11:47439938 A/G cg18512352 chr11:47633146 NA 0.36 7.13 0.37 6.5e-12 Subjective well-being; CRC cis rs11690935 0.655 rs12052995 chr2:172537212 A/G cg13550731 chr2:172543902 DYNC1I2 0.7 10.6 0.5 8.79e-23 Schizophrenia; CRC cis rs10242455 0.702 rs73403290 chr7:99157828 C/T cg18809830 chr7:99032528 PTCD1 -1.2 -8.73 -0.43 1.27e-16 Blood metabolite levels; CRC cis rs9381040 0.655 rs2268187 chr6:41042993 G/A cg04346459 chr6:41068666 NFYA;LOC221442 -0.42 -6.21 -0.32 1.62e-9 Alzheimer's disease (late onset); CRC cis rs9517313 0.615 rs4772079 chr13:99090837 C/G cg07423050 chr13:99094983 FARP1 -0.68 -11.59 -0.54 2.87e-26 Neuroticism; CRC trans rs61931739 0.500 rs11836198 chr12:34552782 T/C cg13010199 chr12:38710504 ALG10B 0.46 6.55 0.34 2.27e-10 Morning vs. evening chronotype; CRC cis rs7809950 1.000 rs7782057 chr7:107098877 T/A cg23024343 chr7:107201750 COG5 -0.61 -8.75 -0.43 1.17e-16 Coronary artery disease; CRC trans rs11148252 0.774 rs6561666 chr13:52930045 A/G cg18335740 chr13:41363409 SLC25A15 0.56 9.0 0.44 1.91e-17 Lewy body disease; CRC trans rs1814175 0.586 rs10769603 chr11:49688837 T/C cg11707556 chr5:10655725 ANKRD33B -0.5 -9.25 -0.45 2.86e-18 Height; CRC cis rs2292884 0.505 rs77856818 chr2:238402830 G/A cg14458575 chr2:238380390 NA 0.82 10.36 0.5 5.73e-22 Prostate cancer; CRC trans rs2797160 1.000 rs1739375 chr6:126012013 T/C cg05039488 chr6:79577232 IRAK1BP1 0.5 7.51 0.38 5.69e-13 Endometrial cancer; CRC cis rs2576037 0.583 rs9947131 chr18:44534769 G/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.62 10.25 0.49 1.36e-21 Personality dimensions; CRC cis rs425277 0.500 rs908744 chr1:2038893 G/A cg19257562 chr1:2043853 PRKCZ 0.37 6.24 0.33 1.31e-9 Height; CRC cis rs2243480 1.000 rs316318 chr7:65612904 A/G cg25985355 chr7:65971099 NA -0.55 -6.23 -0.32 1.41e-9 Diabetic kidney disease; CRC trans rs9914544 0.545 rs3826380 chr17:18793225 A/G cg21372672 chr17:16614065 CCDC144A -0.38 -6.09 -0.32 3.09e-9 Educational attainment (years of education); CRC cis rs4713675 0.565 rs4711341 chr6:33690797 A/G cg14003231 chr6:33640908 ITPR3 0.49 8.02 0.4 1.85e-14 Plateletcrit; CRC cis rs208520 0.909 rs9345809 chr6:67017543 T/C cg07460842 chr6:66804631 NA 0.84 9.91 0.48 1.91e-20 Exhaled nitric oxide output; CRC cis rs9814567 0.806 rs4535271 chr3:134321669 T/A cg06541857 chr3:134203789 ANAPC13;CEP63 -0.37 -5.8 -0.3 1.58e-8 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs10971721 0.643 rs12375483 chr9:33784908 C/A cg13495928 chr9:33750294 PRSS3 0.66 5.92 0.31 8.05e-9 Body mass index; CRC cis rs2014572 0.967 rs7259978 chr19:57756129 C/T cg24459738 chr19:57751996 ZNF805 -0.53 -8.19 -0.41 5.93e-15 Hyperactive-impulsive symptoms; CRC cis rs28386778 0.897 rs1062787 chr17:61896004 T/C cg11494091 chr17:61959527 GH2 0.63 10.64 0.51 6.32e-23 Prudent dietary pattern; CRC cis rs7727544 0.606 rs2631360 chr5:131707429 A/G cg14196790 chr5:131705035 SLC22A5 0.42 7.29 0.37 2.35e-12 Blood metabolite levels; CRC cis rs7843479 0.965 rs733543 chr8:21835465 A/G cg17168535 chr8:21777572 XPO7 0.56 9.25 0.45 2.96e-18 Mean corpuscular volume; CRC cis rs6500602 0.647 rs1659497 chr16:4594635 G/A cg08645402 chr16:4508243 NA -0.59 -10.34 -0.5 6.79e-22 Schizophrenia; CRC cis rs8040855 0.599 rs4577058 chr15:85726458 T/C cg04831495 chr15:85060580 GOLGA6L5 0.37 5.7 0.3 2.71e-8 Bulimia nervosa; CRC cis rs929354 0.629 rs6950739 chr7:156982450 T/C cg16102536 chr7:156981717 UBE3C 0.4 6.77 0.35 5.93e-11 Body mass index; CRC cis rs6691722 0.503 rs3765432 chr1:24706461 A/G cg02336364 chr1:24764700 NIPAL3 0.38 6.35 0.33 7e-10 Response to interferon beta in multiple sclerosis; CRC cis rs4680 0.737 rs4646312 chr22:19948337 C/T cg06346307 chr22:19949965 COMT 0.28 6.9 0.36 2.72e-11 Blood metabolite levels; CRC cis rs7412746 0.553 rs59337856 chr1:150746406 G/T cg15448220 chr1:150897856 SETDB1 0.51 7.19 0.37 4.25e-12 Melanoma; CRC cis rs832540 0.556 rs4146565 chr5:56093825 T/C cg03609598 chr5:56110824 MAP3K1 -0.43 -5.7 -0.3 2.62e-8 Coronary artery disease; CRC trans rs7615952 0.576 rs4646748 chr3:125826329 G/A cg07211511 chr3:129823064 LOC729375 -0.68 -9.09 -0.45 9.33e-18 Blood pressure (smoking interaction); CRC cis rs6681460 1.000 rs6696927 chr1:67070381 A/G cg02459107 chr1:67143332 SGIP1 0.43 7.61 0.39 2.94e-13 Presence of antiphospholipid antibodies; CRC cis rs7660520 0.557 rs76004373 chr4:183731011 C/G cg25287198 chr4:183728479 NA 0.52 5.85 0.31 1.21e-8 Pediatric autoimmune diseases; CRC cis rs2637266 0.519 rs1907328 chr10:78253135 C/T cg18941641 chr10:78392320 NA -0.35 -5.81 -0.3 1.5e-8 Pulmonary function; CRC cis rs362272 0.524 rs2749781 chr4:3346617 T/C cg01612440 chr4:3296283 NA 0.41 5.8 0.3 1.52e-8 Serum sulfate level; CRC trans rs7726839 0.561 rs72703050 chr5:582917 A/C cg25482853 chr8:67687455 SGK3 1.01 12.13 0.56 3.07e-28 Obesity-related traits; CRC trans rs12599106 0.660 rs12919333 chr16:34991336 C/T cg26668828 chr6:292823 DUSP22 -0.67 -9.83 -0.48 3.68e-20 Menopause (age at onset); CRC cis rs9368481 0.554 rs2754603 chr6:26965139 T/C cg10547057 chr6:26987810 LOC100270746;C6orf41 -0.41 -5.82 -0.31 1.39e-8 Autism spectrum disorder or schizophrenia; CRC cis rs58688157 0.705 rs12800061 chr11:587425 C/A cg16486109 chr11:613632 IRF7 0.72 11.71 0.54 9.99e-27 Systemic lupus erythematosus; CRC trans rs66573146 0.808 rs56268690 chr4:6923887 C/T cg07817883 chr1:32538562 TMEM39B 1.49 12.21 0.56 1.59e-28 Granulocyte percentage of myeloid white cells; CRC cis rs2836974 0.568 rs2142111 chr21:40549289 G/C cg22974920 chr21:40686053 BRWD1 0.44 5.98 0.31 5.85e-9 Cognitive function; CRC cis rs524281 0.861 rs11227403 chr11:65858428 T/C cg16950941 chr11:66035639 RAB1B -0.6 -7.39 -0.38 1.23e-12 Electroencephalogram traits; CRC cis rs870825 0.655 rs28604350 chr4:185638723 G/A cg04058563 chr4:185651563 MLF1IP 0.73 9.33 0.46 1.67e-18 Blood protein levels; CRC cis rs9549328 0.642 rs2993343 chr13:113616844 C/G cg20742385 chr13:113633654 MCF2L 0.55 9.23 0.45 3.35e-18 Systolic blood pressure; CRC cis rs911119 1.000 rs2016161 chr20:23621174 G/T cg16589663 chr20:23618590 CST3 -0.61 -8.34 -0.42 2.05e-15 Chronic kidney disease; CRC cis rs28386778 0.897 rs11654841 chr17:61838259 C/T cg06873352 chr17:61820015 STRADA 0.76 14.25 0.62 3.29e-36 Prudent dietary pattern; CRC cis rs9435341 0.965 rs9435441 chr1:107603330 C/G cg11070056 chr1:107600091 PRMT6 -0.4 -6.16 -0.32 2.16e-9 Facial morphology (factor 21, depth of nasal alae); CRC cis rs2404602 0.647 rs11072628 chr15:77107761 C/A cg03037974 chr15:76606532 NA -0.51 -7.24 -0.37 3.14e-12 Blood metabolite levels; CRC cis rs611744 0.573 rs674580 chr8:109251690 C/G cg18478394 chr8:109455254 TTC35 0.41 6.09 0.32 3.19e-9 Dupuytren's disease; CRC cis rs262150 0.788 rs2657408 chr7:158782275 A/G cg04239562 chr7:158767014 NA 0.4 6.29 0.33 1.02e-9 Facial morphology (factor 20); CRC cis rs10489202 0.632 rs202273 chr1:167919963 A/G cg24449463 chr1:168025552 DCAF6 -0.57 -8.36 -0.42 1.82e-15 Schizophrenia; CRC cis rs7811142 0.775 rs1059129 chr7:99926522 A/G cg07160278 chr7:100027354 MEPCE;ZCWPW1 0.98 13.48 0.6 2.75e-33 Platelet count; CRC cis rs9393692 0.905 rs9357004 chr6:26303319 A/G cg00631329 chr6:26305371 NA -0.65 -12.98 -0.58 2.23e-31 Educational attainment; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg18652453 chr5:68665041 TAF9;RAD17 0.41 6.21 0.32 1.6e-9 Intelligence (multi-trait analysis); CRC trans rs35110281 0.511 rs2298562 chr21:45085236 A/G cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.39 6.25 0.33 1.29e-9 Mean corpuscular volume; CRC cis rs78456975 0.943 rs13385274 chr2:1576791 A/T cg12573674 chr2:1569213 NA -0.68 -7.74 -0.39 1.22e-13 Placebo response in major depressive disorder (% change in symptom score); CRC cis rs12142240 0.698 rs28578741 chr1:46825176 T/C cg14993813 chr1:46806288 NSUN4 -0.49 -6.22 -0.32 1.55e-9 Menopause (age at onset); CRC cis rs66573146 1.000 rs73088528 chr4:6967747 G/C cg00086871 chr4:6988644 TBC1D14 1.02 7.86 0.4 5.66e-14 Granulocyte percentage of myeloid white cells; CRC cis rs992157 0.731 rs1399132 chr2:219159770 G/A cg13835894 chr2:219148914 PNKD;TMBIM1 0.3 5.87 0.31 1.05e-8 Colorectal cancer; CRC cis rs1448094 0.512 rs6539924 chr12:86236935 T/C cg02569458 chr12:86230093 RASSF9 0.43 7.27 0.37 2.56e-12 Major depressive disorder; CRC cis rs898097 0.801 rs68141193 chr17:80878816 C/T cg16060761 chr17:80687452 NA 0.46 6.64 0.34 1.33e-10 Breast cancer; CRC cis rs12594515 0.874 rs8032878 chr15:45998015 A/G cg22117107 chr15:45993392 NA -0.43 -8.69 -0.43 1.73e-16 Waist circumference;Weight; CRC cis rs875971 0.862 rs1968126 chr7:66057004 A/G cg11764359 chr7:65958608 NA -0.59 -8.75 -0.43 1.13e-16 Aortic root size; CRC cis rs7666738 0.830 rs6832568 chr4:98994061 G/A cg05340658 chr4:99064831 C4orf37 0.61 9.54 0.47 3.44e-19 Colonoscopy-negative controls vs population controls; CRC cis rs4930103 0.935 rs2525881 chr11:2019333 T/C cg23202291 chr11:1979235 NA 0.48 6.59 0.34 1.78e-10 DNA methylation (parent-of-origin);DNA methylation (variation); CRC cis rs11233250 0.502 rs11233268 chr11:82405067 A/G cg17391194 chr11:82401662 NA 0.42 6.39 0.33 5.75e-10 Glioblastoma;Glioma; CRC cis rs9325144 0.505 rs10785560 chr12:38636622 C/T cg26384229 chr12:38710491 ALG10B 0.54 8.07 0.41 1.37e-14 Morning vs. evening chronotype; CRC cis rs9467773 0.587 rs10946812 chr6:26344975 G/C cg09904177 chr6:26538194 HMGN4 -0.47 -6.71 -0.35 8.69e-11 Intelligence (multi-trait analysis); CRC cis rs748404 0.660 rs2602141 chr15:43724646 A/C cg15269541 chr15:43626905 ADAL -0.37 -5.94 -0.31 7.1e-9 Lung cancer; CRC cis rs6088580 0.634 rs6058073 chr20:33116483 T/C cg24642439 chr20:33292090 TP53INP2 0.4 6.62 0.34 1.45e-10 Glomerular filtration rate (creatinine); CRC cis rs1552244 0.872 rs35988239 chr3:10074145 G/T cg02579736 chr3:10068473 FANCD2;CIDECP 1.07 12.11 0.56 3.61e-28 Alzheimer's disease; CRC cis rs7615952 0.800 rs2062773 chr3:125639648 T/C cg05084668 chr3:125655381 ALG1L -0.6 -8.82 -0.44 6.96e-17 Blood pressure (smoking interaction); CRC cis rs7493 0.950 rs56265549 chr7:95047155 G/A cg21856205 chr7:94953877 PON1 -0.48 -6.28 -0.33 1.1e-9 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs9910055 0.762 rs6503489 chr17:42246289 G/A cg09913183 chr17:42254507 C17orf65;ASB16 0.56 8.29 0.42 2.88e-15 Total body bone mineral density; CRC cis rs9549328 0.642 rs2993343 chr13:113616844 C/G cg08614441 chr13:113633676 MCF2L 0.39 6.87 0.35 3.19e-11 Systolic blood pressure; CRC cis rs7568458 0.709 rs2028898 chr2:85777270 G/A cg02493740 chr2:85810744 VAMP5 -0.55 -8.3 -0.42 2.75e-15 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); CRC cis rs875971 0.895 rs6460300 chr7:65952924 A/G cg18912574 chr7:65842487 NCRNA00174 0.36 6.1 0.32 2.99e-9 Aortic root size; CRC cis rs908922 0.676 rs4240887 chr1:152530510 C/T cg09873164 chr1:152488093 CRCT1 -0.36 -6.06 -0.32 3.69e-9 Hair morphology; CRC cis rs4891159 0.790 rs4891018 chr18:74127082 A/T cg24786174 chr18:74118243 ZNF516 -0.86 -17.36 -0.69 2.26e-48 Longevity; CRC cis rs798554 0.704 rs798512 chr7:2782592 C/G cg04166393 chr7:2884313 GNA12 0.41 6.34 0.33 7.48e-10 Height; CRC cis rs2839186 0.900 rs2839196 chr21:47708037 G/A cg13012494 chr21:47604986 C21orf56 0.42 6.25 0.33 1.27e-9 Testicular germ cell tumor; CRC cis rs7552404 1.000 rs11161521 chr1:76216330 T/C cg03433033 chr1:76189801 ACADM 0.82 11.28 0.53 3.58e-25 Blood metabolite levels;Acylcarnitine levels; CRC cis rs801193 1.000 rs4717310 chr7:66161007 C/T cg18876405 chr7:65276391 NA 0.61 10.75 0.51 2.7e-23 Aortic root size; CRC cis rs875971 0.545 rs7810213 chr7:65946579 G/C cg18876405 chr7:65276391 NA 0.45 6.22 0.32 1.51e-9 Aortic root size; CRC cis rs6088590 0.707 rs67159833 chr20:33488079 T/C cg08999081 chr20:33150536 PIGU 0.52 8.05 0.41 1.49e-14 Coronary artery disease; CRC cis rs9902453 1.000 rs6505152 chr17:28331466 T/C cg26525008 chr17:28256777 EFCAB5;SSH2 -0.59 -8.86 -0.44 4.95e-17 Coffee consumption (cups per day); CRC cis rs1865760 0.613 rs7749342 chr6:25920265 T/C cg16482183 chr6:26056742 HIST1H1C 0.43 6.39 0.33 5.79e-10 Height; CRC cis rs11212617 0.967 rs5023001 chr11:108335538 A/T cg01991180 chr11:108092276 ATM;NPAT 0.4 5.79 0.3 1.61e-8 Response to metformin in type 2 diabetes (glycemic); CRC cis rs17023223 0.537 rs1325938 chr1:119582642 C/T cg05756136 chr1:119680316 WARS2 -0.47 -6.33 -0.33 7.9e-10 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for BMI in active individuals; CRC cis rs8031584 0.560 rs1056118 chr15:31203786 G/A cg19680485 chr15:31195859 MTMR15 0.48 6.71 0.35 8.38e-11 Huntington's disease progression; CRC cis rs9393692 0.557 rs12660432 chr6:26317384 C/T cg00631329 chr6:26305371 NA -0.52 -8.72 -0.43 1.42e-16 Educational attainment; CRC cis rs881375 0.678 rs10760129 chr9:123700183 T/C cg09586646 chr9:123605570 PSMD5;LOC253039 0.46 6.89 0.36 2.84e-11 Rheumatoid arthritis; CRC cis rs7089973 0.604 rs765174 chr10:116601888 C/T cg23260525 chr10:116636907 FAM160B1 0.35 8.11 0.41 1.04e-14 Bipolar disorder or attention deficit hyperactivity disorder; CRC cis rs13082711 0.516 rs1492339 chr3:27371526 A/C cg02860705 chr3:27208620 NA -0.52 -7.52 -0.38 5.39e-13 Systolic blood pressure;Diastolic blood pressure;Blood pressure; CRC cis rs9462846 1.000 rs9462846 chr6:42861581 A/C cg02353165 chr6:42928485 GNMT 0.54 6.91 0.36 2.57e-11 Blood protein levels; CRC cis rs6121246 0.909 rs6060929 chr20:30345914 C/T cg13852791 chr20:30311386 BCL2L1 0.69 10.77 0.51 2.2e-23 Mean corpuscular hemoglobin; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg20607513 chr21:46708029 POFUT2;LOC642852 0.37 6.05 0.32 3.93e-9 Liver disease severity in Alagille syndrome; CRC cis rs889312 0.500 rs33328 chr5:56143419 T/C cg24531977 chr5:56204891 C5orf35 -0.45 -6.83 -0.35 4.08e-11 Breast cancer;Breast cancer (early onset); CRC cis rs2274471 0.645 rs55787634 chr9:5116064 T/A cg03390472 chr9:5043263 JAK2 -0.55 -6.32 -0.33 8.31e-10 Crohn's disease; CRC trans rs6693295 0.793 rs2788021 chr1:246248704 A/G cg03680032 chr11:94965610 SESN3 0.47 6.02 0.31 4.76e-9 Migraine - clinic-based;Migraine with aura; CRC cis rs10504229 0.683 rs10504225 chr8:58145121 A/T cg22535103 chr8:58192502 C8orf71 -0.7 -9.37 -0.46 1.19e-18 Developmental language disorder (linguistic errors); CRC cis rs6062302 0.522 rs11696202 chr20:62246292 G/C cg09650180 chr20:62225654 GMEB2 -0.51 -6.73 -0.35 7.63e-11 Glioblastoma; CRC cis rs2274273 0.588 rs7155054 chr14:55750662 A/G cg10130446 chr14:55658398 DLGAP5 -0.41 -5.89 -0.31 9.37e-9 Protein biomarker; CRC trans rs596169 0.541 rs6667536 chr1:219215137 G/A cg09853702 chr12:47665230 NA 0.82 6.39 0.33 5.67e-10 Intraocular pressure; CRC cis rs12142240 0.698 rs12385697 chr1:46818898 T/C cg00530320 chr1:46809349 NSUN4 0.58 7.93 0.4 3.43e-14 Menopause (age at onset); CRC cis rs9303280 0.901 rs869402 chr17:38068043 C/T cg11212589 chr17:38028394 ZPBP2 0.44 8.27 0.41 3.34e-15 Self-reported allergy; CRC cis rs12137294 0.866 rs896320 chr1:205205347 T/C cg24159697 chr1:205181237 DSTYK -0.34 -6.22 -0.32 1.54e-9 Red cell distribution width; CRC cis rs1832871 0.672 rs1342211 chr6:158759496 G/T cg07165851 chr6:158734300 TULP4 0.62 7.88 0.4 4.67e-14 Height; CRC cis rs478304 0.654 rs11227260 chr11:65461158 G/T cg05805236 chr11:65401703 PCNXL3 -0.4 -6.09 -0.32 3.07e-9 Acne (severe); CRC trans rs561341 1.000 rs537166 chr17:30326827 C/T cg27661571 chr11:113659931 NA -0.7 -8.72 -0.43 1.43e-16 Hip circumference adjusted for BMI; CRC trans rs11098499 0.754 rs4443261 chr4:120249301 T/C cg25214090 chr10:38739885 LOC399744 0.53 8.34 0.42 2e-15 Corneal astigmatism; CRC cis rs7662987 0.517 rs2851277 chr4:100022910 G/T cg12011299 chr4:100065546 ADH4 0.49 9.27 0.46 2.46e-18 Smoking initiation; CRC cis rs2933343 1.000 rs2933343 chr3:128658492 G/A cg11901034 chr3:128598214 ACAD9 -0.52 -6.33 -0.33 8.23e-10 IgG glycosylation; CRC cis rs2333194 0.875 rs10220356 chr14:73809476 C/T cg19682024 chr14:74008259 HEATR4;ACOT1 0.41 6.13 0.32 2.45e-9 Bipolar disorder with mood-incongruent psychosis; CRC cis rs9402673 0.517 rs978036 chr6:135342903 C/T cg24558204 chr6:135376177 HBS1L 0.52 8.21 0.41 5.05e-15 Reticulocyte count;High light scatter reticulocyte count; CRC cis rs17065868 0.764 rs73188731 chr13:45031494 A/C cg10246903 chr13:45222710 NA 0.54 5.69 0.3 2.79e-8 Antineutrophil cytoplasmic antibody-associated vasculitis; CRC cis rs7020830 0.867 rs13301916 chr9:37361455 A/C cg14294708 chr9:37120828 ZCCHC7 1.09 21.23 0.76 1.34e-63 Schizophrenia; CRC cis rs3858526 0.883 rs11039686 chr11:5948725 T/C cg13902645 chr11:5959945 NA -0.61 -8.43 -0.42 1.13e-15 DNA methylation (variation); CRC cis rs17767392 0.918 rs34533948 chr14:71772727 C/A cg13720639 chr14:72061746 SIPA1L1 -0.53 -6.86 -0.35 3.45e-11 Mitral valve prolapse; CRC cis rs7647973 0.516 rs12490393 chr3:49196132 C/T cg07636037 chr3:49044803 WDR6 0.85 13.15 0.59 4.99e-32 Menarche (age at onset); CRC trans rs12310956 0.532 rs11052922 chr12:33957476 A/G cg26384229 chr12:38710491 ALG10B 0.46 6.32 0.33 8.5e-10 Morning vs. evening chronotype; CRC trans rs459571 0.920 rs455073 chr9:136909141 G/C cg09836344 chr4:1243392 C4orf42;CTBP1 -0.8 -10.79 -0.51 1.93e-23 Platelet distribution width; CRC cis rs3806843 0.966 rs7710380 chr5:140156264 T/C cg19875535 chr5:140030758 IK 0.63 10.24 0.49 1.54e-21 Depressive symptoms (multi-trait analysis); CRC cis rs4474465 0.790 rs12363982 chr11:78229167 C/T cg27205649 chr11:78285834 NARS2 0.48 6.04 0.32 4.28e-9 Alzheimer's disease (survival time); CRC cis rs780096 0.506 rs2288155 chr2:27714526 T/C cg24768116 chr2:27665128 KRTCAP3 -0.35 -7.66 -0.39 2.03e-13 Total body bone mineral density; CRC cis rs67478160 0.634 rs1955660 chr14:104229985 C/T cg08213375 chr14:104286397 PPP1R13B 0.6 12.22 0.56 1.4e-28 Schizophrenia; CRC cis rs10256972 0.967 rs4723338 chr7:1036241 A/G cg07930192 chr7:1003750 NA 0.44 6.81 0.35 4.58e-11 Longevity;Endometriosis; CRC cis rs57221529 0.825 rs72703051 chr5:582997 G/A cg09021430 chr5:549028 NA -0.67 -6.8 -0.35 4.92e-11 Lung disease severity in cystic fibrosis; CRC cis rs4563143 0.663 rs2218396 chr19:29236392 C/T cg14983838 chr19:29218262 NA 0.53 8.0 0.4 2.18e-14 Methadone dose in opioid dependence; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg25940730 chr4:16228647 TAPT1;FLJ39653 0.49 7.87 0.4 5.31e-14 Liver disease severity in Alagille syndrome; CRC trans rs8073060 0.859 rs17550268 chr17:33874678 T/C cg19694781 chr19:47549865 TMEM160 0.7 9.9 0.48 2.1e-20 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; CRC cis rs12597458 0.763 rs3213422 chr16:72042682 A/C cg01557791 chr16:72042693 DHODH 0.63 9.67 0.47 1.28e-19 Prostate cancer; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg18036573 chr7:92219856 FAM133B 0.44 6.13 0.32 2.48e-9 Response to antipsychotic treatment; CRC cis rs9322193 0.923 rs9505823 chr6:149950035 A/C cg13206674 chr6:150067644 NUP43 0.65 9.78 0.47 5.29e-20 Lung cancer; CRC trans rs11098499 0.865 rs28753180 chr4:120405367 A/T cg25214090 chr10:38739885 LOC399744 0.65 10.37 0.5 5.64e-22 Corneal astigmatism; CRC cis rs2739330 0.828 rs5751770 chr22:24252842 A/G cg11060661 chr22:24314208 DDT;DDTL 0.49 8.39 0.42 1.41e-15 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs7772486 0.790 rs3924499 chr6:146232978 A/T cg23711669 chr6:146136114 FBXO30 -0.72 -12.71 -0.57 2.16e-30 Lobe attachment (rater-scored or self-reported); CRC trans rs7615952 0.866 rs6438949 chr3:125650064 G/C cg00769240 chr8:12517080 NA -0.54 -6.71 -0.35 8.78e-11 Blood pressure (smoking interaction); CRC cis rs651907 0.535 rs34743741 chr3:101532448 C/T cg12386194 chr3:101231763 SENP7 0.51 7.29 0.37 2.27e-12 Colorectal cancer; CRC cis rs4713118 0.699 rs573179 chr6:27849676 C/A cg25164649 chr6:28176230 NA 0.58 7.43 0.38 9.73e-13 Parkinson's disease; CRC cis rs1322512 0.761 rs1631293 chr6:152939886 T/C cg03415253 chr6:152958462 SYNE1 -0.41 -6.36 -0.33 6.67e-10 Tonometry; CRC cis rs889312 0.521 rs12651942 chr5:56088484 C/T cg12311346 chr5:56204834 C5orf35 -0.48 -7.38 -0.38 1.3e-12 Breast cancer;Breast cancer (early onset); CRC trans rs1117324 1.000 rs1117324 chr2:21840093 C/T cg07470598 chr14:107239068 NA -0.56 -6.02 -0.31 4.56e-9 Response to antipsychotic treatment; CRC cis rs10504229 0.683 rs56235637 chr8:58106008 T/C cg24829409 chr8:58192753 C8orf71 -0.56 -8.01 -0.4 2.05e-14 Developmental language disorder (linguistic errors); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg22564599 chr17:15466921 FAM18B2 0.4 6.31 0.33 8.89e-10 Liver disease severity in Alagille syndrome; CRC cis rs2239547 0.522 rs2581797 chr3:52972468 C/T cg11645453 chr3:52864694 ITIH4 -0.51 -9.76 -0.47 6.34e-20 Schizophrenia; CRC cis rs17854409 1.000 rs16983290 chr20:61478894 A/G cg19907964 chr20:61473305 TCFL5 -0.47 -6.14 -0.32 2.33e-9 Obesity-related traits; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg17712202 chr19:13261217 IER2;STX10 0.5 7.3 0.37 2.18e-12 Intelligence (multi-trait analysis); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg23303782 chr10:120967744 GRK5 0.43 6.01 0.31 5.01e-9 Response to antipsychotic treatment; CRC cis rs425277 0.585 rs3107157 chr1:2061969 A/G cg12639453 chr1:2035780 PRKCZ -0.34 -6.39 -0.33 5.76e-10 Height; CRC cis rs2929278 0.561 rs3099045 chr15:43923955 A/C cg02155558 chr15:43621948 ADAL;LCMT2 0.46 6.32 0.33 8.68e-10 Schizophrenia; CRC cis rs79387448 0.745 rs7582378 chr2:103162263 C/A cg09003973 chr2:102972529 NA 0.73 8.01 0.4 1.97e-14 Gut microbiota (bacterial taxa); CRC cis rs11229555 0.645 rs11229462 chr11:58209931 A/T cg15696309 chr11:58395628 NA -0.82 -10.45 -0.5 2.81e-22 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; CRC cis rs929354 1.000 rs1182384 chr7:157040642 A/G cg16102536 chr7:156981717 UBE3C -0.39 -6.65 -0.34 1.24e-10 Body mass index; CRC cis rs2739330 0.761 rs5760176 chr22:24402321 A/G cg04234412 chr22:24373322 LOC391322 0.89 16.98 0.68 6.74e-47 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs6951245 1.000 rs28399710 chr7:1070631 G/T cg22907277 chr7:1156413 C7orf50 0.71 7.39 0.38 1.26e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs7605827 0.930 rs1549017 chr2:15617017 T/C cg19274914 chr2:15703543 NA 0.39 5.9 0.31 8.83e-9 Educational attainment (years of education); CRC cis rs172166 0.561 rs149976 chr6:27987776 C/T cg02683197 chr6:28174875 NA -0.47 -6.59 -0.34 1.72e-10 Cardiac Troponin-T levels; CRC cis rs10174077 0.874 rs4664490 chr2:152471923 C/G cg19508488 chr2:152266495 RIF1 -0.48 -6.92 -0.36 2.42e-11 Squamous cell lung carcinoma; CRC cis rs172166 0.611 rs203883 chr6:28078356 A/G cg26587870 chr6:27730563 NA -0.39 -5.86 -0.31 1.13e-8 Cardiac Troponin-T levels; CRC cis rs1005277 0.579 rs2474599 chr10:38438939 A/G cg00409905 chr10:38381863 ZNF37A -0.65 -10.9 -0.52 8e-24 Extrinsic epigenetic age acceleration; CRC cis rs4819052 0.851 rs2877019 chr21:46658647 G/A cg19498844 chr21:46707878 POFUT2;LOC642852 0.77 10.97 0.52 4.68e-24 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs7208859 0.673 rs3764420 chr17:29164154 A/G cg14008862 chr17:28927542 LRRC37B2 0.55 5.8 0.3 1.56e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs477692 0.637 rs7098619 chr10:131315856 C/T cg05714579 chr10:131428358 MGMT 0.5 6.99 0.36 1.5e-11 Response to temozolomide; CRC cis rs2933343 1.000 rs789227 chr3:128600585 C/G cg11901034 chr3:128598214 ACAD9 -0.5 -6.19 -0.32 1.8e-9 IgG glycosylation; CRC cis rs6502050 0.835 rs7213172 chr17:80085703 G/T cg11859384 chr17:80120422 CCDC57 0.37 5.82 0.31 1.36e-8 Life satisfaction; CRC cis rs9291683 0.530 rs17246501 chr4:9985710 A/C cg00071950 chr4:10020882 SLC2A9 0.65 11.91 0.55 2e-27 Bone mineral density; CRC cis rs73200209 0.912 rs11609898 chr12:116638445 G/T cg01776926 chr12:116560359 MED13L 0.47 5.77 0.3 1.82e-8 Total body bone mineral density; CRC trans rs10028773 0.700 rs35653026 chr4:120248378 A/G cg25214090 chr10:38739885 LOC399744 0.54 8.16 0.41 7.12e-15 Educational attainment; CRC cis rs1395 0.744 rs1975384 chr2:27542041 C/T cg23587288 chr2:27483067 SLC30A3 -0.43 -6.29 -0.33 1.01e-9 Blood metabolite levels; CRC cis rs1218582 0.741 rs4339857 chr1:154888962 A/G cg24250549 chr1:154909240 PMVK 0.65 11.35 0.53 1.97e-25 Prostate cancer; CRC cis rs9549367 0.601 rs558869 chr13:113849932 G/T cg18105134 chr13:113819100 PROZ 0.85 13.44 0.6 3.84e-33 Platelet distribution width; CRC cis rs939658 0.805 rs36068099 chr15:79438598 G/C cg17916960 chr15:79447300 NA -0.43 -7.03 -0.36 1.18e-11 Refractive error; CRC cis rs4862750 0.832 rs6836076 chr4:187899660 A/C cg10295955 chr4:187884368 NA -1.06 -28.72 -0.85 1.21e-91 Lobe attachment (rater-scored or self-reported); CRC cis rs9522267 0.535 rs9522291 chr13:112233761 T/C cg14352298 chr13:112236639 NA 0.29 6.67 0.35 1.1e-10 Hepatitis; CRC cis rs554111 1.000 rs554111 chr1:21042300 C/G cg08890418 chr1:21044141 KIF17 0.32 5.75 0.3 2.02e-8 Facial morphology (factor 17, height of vermillion upper lip); CRC trans rs7937682 0.847 rs11213948 chr11:111464401 G/A cg18187862 chr3:45730750 SACM1L 0.43 6.14 0.32 2.38e-9 Primary sclerosing cholangitis; CRC cis rs58688157 0.705 rs936469 chr11:606749 G/A cg16486109 chr11:613632 IRF7 0.73 12.41 0.56 2.89e-29 Systemic lupus erythematosus; CRC cis rs7224737 1.000 rs2240009 chr17:40283142 C/G cg02228675 chr17:40259724 DHX58 -0.5 -7.01 -0.36 1.38e-11 Fibrinogen levels; CRC cis rs57221529 0.709 rs4957056 chr5:570105 T/C cg09021430 chr5:549028 NA -0.7 -7.87 -0.4 5.06e-14 Lung disease severity in cystic fibrosis; CRC cis rs853679 0.546 rs200990 chr6:27815823 T/G cg23259851 chr6:27775964 HIST1H2AI;HIST1H2BL 0.66 5.67 0.3 3.17e-8 Depression; CRC cis rs4332037 0.539 rs11763750 chr7:2080114 G/A cg25834613 chr7:1915315 MAD1L1 -0.42 -6.04 -0.32 4.14e-9 Bipolar disorder; CRC cis rs875971 1.000 rs6958271 chr7:65979331 A/C cg12463550 chr7:65579703 CRCP 0.47 6.76 0.35 6.2e-11 Aortic root size; CRC cis rs6424115 0.830 rs6680132 chr1:24198804 T/C cg15997130 chr1:24165203 NA 0.71 10.46 0.5 2.79e-22 Immature fraction of reticulocytes; CRC cis rs1005277 0.579 rs2505240 chr10:38442419 G/T cg25427524 chr10:38739819 LOC399744 -0.76 -13.4 -0.59 5.88e-33 Extrinsic epigenetic age acceleration; CRC cis rs11792861 0.781 rs17729408 chr9:111740860 A/G cg05043794 chr9:111880884 C9orf5 0.32 5.8 0.3 1.58e-8 Menarche (age at onset); CRC cis rs7949030 1.000 rs7949030 chr11:62394881 A/G cg11742103 chr11:62369870 EML3;MTA2 0.54 9.87 0.48 2.63e-20 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; CRC cis rs34172651 0.517 rs11647120 chr16:24819806 A/G cg06505273 chr16:24850292 NA 0.53 6.86 0.35 3.5e-11 Intelligence (multi-trait analysis); CRC cis rs12936587 0.576 rs8073975 chr17:17555631 G/T cg04398451 chr17:18023971 MYO15A 0.36 5.93 0.31 7.68e-9 Hip circumference;Coronary artery disease or large artery stroke;Coronary heart disease;Coronary artery disease; CRC cis rs864537 0.646 rs1773542 chr1:167432949 T/C cg09179987 chr1:167433047 CD247 0.56 8.84 0.44 5.94e-17 Celiac disease or Rheumatoid arthritis;Celiac disease; CRC trans rs6951245 0.572 rs74791540 chr7:1061913 C/A cg13565492 chr6:43139072 SRF -0.83 -6.14 -0.32 2.34e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs2404602 0.684 rs12591622 chr15:76930655 A/T cg03037974 chr15:76606532 NA -0.5 -7.12 -0.37 6.62e-12 Blood metabolite levels; CRC cis rs9372498 0.536 rs9489467 chr6:118935206 C/T cg07617317 chr6:118971624 C6orf204 0.47 5.68 0.3 2.91e-8 Diastolic blood pressure; CRC cis rs561341 0.883 rs7406056 chr17:30220224 C/T cg00745463 chr17:30367425 LRRC37B -0.71 -8.02 -0.4 1.84e-14 Hip circumference adjusted for BMI; CRC cis rs875971 0.895 rs3857684 chr7:65938158 G/C cg11764359 chr7:65958608 NA 0.62 10.01 0.48 9.08e-21 Aortic root size; CRC cis rs1451375 0.652 rs7803788 chr7:50625898 A/G cg14593290 chr7:50529359 DDC -0.58 -7.72 -0.39 1.37e-13 Malaria; CRC cis rs1552244 0.748 rs113890152 chr3:10085986 A/G cg10729496 chr3:10149963 C3orf24 0.56 7.23 0.37 3.32e-12 Alzheimer's disease; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg07474652 chr3:47823067 SMARCC1 -0.41 -6.35 -0.33 7.09e-10 Myopia (pathological); CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg14866419 chr14:100704911 YY1 0.43 5.96 0.31 6.4e-9 Anxiety disorder; CRC cis rs2115630 0.936 rs8033459 chr15:85253258 C/T cg09876464 chr15:85330779 ZNF592 0.44 7.3 0.37 2.22e-12 P wave terminal force; CRC cis rs3858526 0.514 rs1530973 chr11:5861449 C/T cg05234568 chr11:5960015 NA -0.63 -8.9 -0.44 3.86e-17 DNA methylation (variation); CRC cis rs881375 0.933 rs4837804 chr9:123705304 C/G cg09586646 chr9:123605570 PSMD5;LOC253039 0.46 6.33 0.33 7.8e-10 Rheumatoid arthritis; CRC cis rs514406 0.825 rs487453 chr1:53271225 T/C cg27535305 chr1:53392650 SCP2 0.38 7.3 0.37 2.22e-12 Monocyte count; CRC cis rs7493 1.000 rs7493 chr7:95034775 C/G cg04155289 chr7:94953770 PON1 0.59 7.42 0.38 1.02e-12 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs10504229 0.593 rs80174614 chr8:58024631 G/A cg02725872 chr8:58115012 NA -0.44 -6.61 -0.34 1.51e-10 Developmental language disorder (linguistic errors); CRC cis rs9462027 0.628 rs10807141 chr6:34693111 A/G cg07306190 chr6:34760872 UHRF1BP1 0.34 6.07 0.32 3.49e-9 Systemic lupus erythematosus; CRC cis rs6751744 0.513 rs7563368 chr2:160457075 C/T cg08347373 chr2:160653686 CD302 0.36 5.99 0.31 5.53e-9 Dysphagia; CRC trans rs7618501 1.000 rs7648987 chr3:49868455 A/G cg21582582 chr3:182698605 DCUN1D1 0.53 7.84 0.4 6.34e-14 Intelligence (multi-trait analysis); CRC cis rs10751667 0.643 rs10902245 chr11:953014 C/T ch.11.42038R chr11:967971 AP2A2 -0.59 -10.13 -0.49 3.5e-21 Alzheimer's disease (late onset); CRC cis rs9308731 0.644 rs4627572 chr2:111873378 T/C cg18646521 chr2:111875858 NA 0.36 5.7 0.3 2.69e-8 Chronic lymphocytic leukemia; CRC cis rs2302190 1.000 rs2302190 chr17:56584508 A/G cg25885038 chr17:56607967 SEPT4 -0.41 -6.66 -0.34 1.15e-10 Vitamin D levels; CRC cis rs877282 0.898 rs11253340 chr10:764786 G/T cg17470449 chr10:769945 NA 0.66 8.48 0.42 7.57e-16 Uric acid levels; CRC cis rs79349575 0.783 rs832410 chr17:46972865 C/T cg22482690 chr17:47019901 SNF8 0.48 8.09 0.41 1.2e-14 Type 2 diabetes; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg19284510 chr4:128886615 MFSD8;C4orf29 0.4 6.02 0.31 4.72e-9 Intelligence (multi-trait analysis); CRC cis rs7917772 0.536 rs17783771 chr10:104410736 C/T cg11453585 chr10:104263688 ACTR1A;SUFU 0.88 13.74 0.6 2.92e-34 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC cis rs7772486 0.790 rs9497427 chr6:146238302 T/A cg13319975 chr6:146136371 FBXO30 0.39 5.84 0.31 1.24e-8 Lobe attachment (rater-scored or self-reported); CRC cis rs7666738 0.830 rs3911282 chr4:99037602 T/A cg05340658 chr4:99064831 C4orf37 0.61 9.43 0.46 7.65e-19 Colonoscopy-negative controls vs population controls; CRC cis rs847577 0.748 rs940430 chr7:97716540 A/G cg21770322 chr7:97807741 LMTK2 0.84 18.44 0.71 1.18e-52 Breast cancer; CRC cis rs9733 0.544 rs2867302 chr1:150653650 T/C cg17724175 chr1:150552817 MCL1 0.59 9.41 0.46 8.98e-19 Tonsillectomy; CRC cis rs7677751 0.806 rs7682912 chr4:55085620 T/G cg17187183 chr4:55093834 PDGFRA 0.52 7.57 0.38 3.9e-13 Corneal astigmatism; CRC cis rs8180040 0.726 rs7610636 chr3:47064436 A/C cg27129171 chr3:47204927 SETD2 -0.79 -13.18 -0.59 3.98e-32 Colorectal cancer; CRC cis rs6540559 1.000 rs6540559 chr1:209982025 G/A cg25204440 chr1:209979598 IRF6 0.5 7.08 0.36 8.78e-12 Cleft lip with or without cleft palate; CRC cis rs57590327 0.503 rs13062741 chr3:81887124 C/T cg07356753 chr3:81810745 GBE1 -0.58 -7.91 -0.4 3.86e-14 Extraversion; CRC cis rs754466 0.651 rs10824583 chr10:79619402 C/T cg26805224 chr10:79626177 DLG5 0.57 8.45 0.42 9.46e-16 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs17345786 0.861 rs11707689 chr3:101086475 A/G cg12386194 chr3:101231763 SENP7 0.56 7.31 0.37 2.03e-12 Colonoscopy-negative controls vs population controls; CRC cis rs2836974 0.897 rs2836973 chr21:40654928 A/G cg11890956 chr21:40555474 PSMG1 1.13 21.2 0.76 1.69e-63 Cognitive function; CRC cis rs1448094 0.511 rs10746353 chr12:86150146 A/T cg18827107 chr12:86230957 RASSF9 0.39 5.96 0.31 6.52e-9 Major depressive disorder; CRC cis rs9462027 0.628 rs9469863 chr6:34739649 A/G cg07306190 chr6:34760872 UHRF1BP1 -0.35 -6.24 -0.33 1.36e-9 Systemic lupus erythematosus; CRC trans rs10435719 0.902 rs7014580 chr8:11803262 C/G cg08975724 chr8:8085496 FLJ10661 0.42 6.51 0.34 2.77e-10 C-reactive protein levels or triglyceride levels (pleiotropy); CRC cis rs6977660 0.598 rs72591445 chr7:19773035 G/A cg07541023 chr7:19748670 TWISTNB 0.88 8.11 0.41 1.03e-14 Thyroid stimulating hormone; CRC cis rs57590327 0.528 rs7642112 chr3:81674927 C/T cg07356753 chr3:81810745 GBE1 -0.66 -8.51 -0.42 6.32e-16 Extraversion; CRC cis rs1801251 1.000 rs1022330 chr2:233577330 G/A cg25237894 chr2:233734115 C2orf82 0.49 7.99 0.4 2.31e-14 Coronary artery disease; CRC cis rs4689388 0.856 rs4308430 chr4:6294095 A/G cg14416269 chr4:6271139 WFS1 0.4 6.6 0.34 1.62e-10 Type 2 diabetes and other traits;Type 2 diabetes; CRC cis rs3888647 0.561 rs4758617 chr11:2995185 T/A cg25174290 chr11:3078921 CARS 0.41 6.33 0.33 8.21e-10 Type 2 diabetes; CRC cis rs614226 1.000 rs591992 chr12:121019323 T/C cg27489772 chr12:121021490 NA 0.5 6.81 0.35 4.54e-11 Type 1 diabetes nephropathy; CRC cis rs826838 1.000 rs1393537 chr12:38920961 C/T cg26384229 chr12:38710491 ALG10B 0.75 10.41 0.5 3.99e-22 Heart rate; CRC trans rs9291683 0.546 rs13146686 chr4:10034933 A/G cg26043149 chr18:55253948 FECH 0.52 7.66 0.39 2.12e-13 Bone mineral density; CRC cis rs67478160 0.643 rs7156697 chr14:104211136 G/A cg08213375 chr14:104286397 PPP1R13B 0.67 14.1 0.61 1.21e-35 Schizophrenia; CRC cis rs7959452 0.901 rs1384 chr12:69747834 C/T cg20891283 chr12:69753455 YEATS4 0.75 12.24 0.56 1.19e-28 Blood protein levels; CRC cis rs3806843 0.576 rs246064 chr5:140324309 C/G cg19875535 chr5:140030758 IK 0.39 6.02 0.31 4.67e-9 Depressive symptoms (multi-trait analysis); CRC cis rs7399018 0.643 rs6580810 chr12:51610478 C/T cg20712883 chr12:51590929 POU6F1 0.65 8.47 0.42 8.37e-16 Cisplatin-induced ototoxicity; CRC cis rs826838 0.935 rs11183940 chr12:38851642 A/G cg13010199 chr12:38710504 ALG10B 0.46 6.04 0.32 4.14e-9 Heart rate; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg00232805 chr2:97779565 ANKRD36 0.51 6.55 0.34 2.24e-10 Thyroid stimulating hormone; CRC cis rs2816062 0.760 rs2745319 chr1:18895078 G/A cg18795169 chr1:18902165 NA -0.92 -19.57 -0.73 4.36e-57 Urate levels in lean individuals; CRC cis rs473651 0.935 rs520765 chr2:239354712 C/T cg18131467 chr2:239335373 ASB1 1.02 22.78 0.78 1.34e-69 Multiple system atrophy; CRC cis rs4665809 1.000 rs4665298 chr2:26256378 G/A cg27170947 chr2:26402098 FAM59B -0.44 -5.9 -0.31 8.9e-9 Gut microbiome composition (summer); CRC cis rs9814567 1.000 rs1534025 chr3:134313304 C/T cg06109529 chr3:134205091 CEP63;ANAPC13 0.83 12.13 0.56 3.14e-28 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg03399598 chr4:174091002 GALNT7 0.5 6.49 0.34 3.09e-10 Thyroid stimulating hormone; CRC cis rs7647973 0.626 rs4855833 chr3:49657441 A/G cg13072238 chr3:49761600 GMPPB -0.51 -5.92 -0.31 7.96e-9 Menarche (age at onset); CRC cis rs9914988 0.887 rs8078402 chr17:27145124 T/A cg20469991 chr17:27169893 C17orf63 -0.59 -7.19 -0.37 4.48e-12 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs7208859 0.623 rs56018041 chr17:29059985 G/A cg13385521 chr17:29058706 SUZ12P 0.69 7.65 0.39 2.31e-13 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs7799006 0.582 rs7781284 chr7:2339405 G/T cg08027265 chr7:2291960 NA -0.38 -6.37 -0.33 6.47e-10 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs7538876 0.787 rs57142672 chr1:17744536 A/G cg01904812 chr1:17746340 RCC2 0.37 6.05 0.32 3.93e-9 Basal cell carcinoma; CRC cis rs1003719 0.751 rs55992706 chr21:38542749 G/A cg10648535 chr21:38446584 PIGP;TTC3 -0.48 -6.58 -0.34 1.83e-10 Eye color traits; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg11951449 chr1:116519025 SLC22A15 0.4 7.14 0.37 5.88e-12 Liver disease severity in Alagille syndrome; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg07355551 chr20:2489285 ZNF343 0.5 6.52 0.34 2.7e-10 Thyroid stimulating hormone; CRC cis rs12048904 0.964 rs8888 chr1:101338324 A/G cg16556008 chr1:101360663 SLC30A7;EXTL2 0.63 9.49 0.46 4.86e-19 Multiple sclerosis; CRC cis rs593982 0.719 rs11606668 chr11:65472758 A/G cg08755490 chr11:65554678 OVOL1 -0.76 -8.33 -0.42 2.24e-15 Atopic dermatitis; CRC cis rs4285028 0.948 rs35902163 chr3:121649526 G/A cg20356878 chr3:121714668 ILDR1 -0.47 -6.56 -0.34 2.09e-10 Multiple sclerosis; CRC cis rs9807989 0.507 rs1420105 chr2:103035119 A/G cg03938978 chr2:103052716 IL18RAP 0.6 10.4 0.5 4.44e-22 Asthma; CRC cis rs7044106 0.762 rs966396 chr9:123453281 T/C cg09419670 chr9:123605666 PSMD5;LOC253039 0.7 10.75 0.51 2.56e-23 Hip circumference adjusted for BMI; CRC cis rs11971779 0.588 rs6972408 chr7:139071474 T/G cg23387468 chr7:139079360 LUC7L2 0.41 7.04 0.36 1.14e-11 Diisocyanate-induced asthma; CRC cis rs1150688 1 rs1150688 chr6:28162780 T/C cg12172441 chr6:28176163 NA 0.45 6.52 0.34 2.58e-10 Autism spectrum disorder or schizophrenia; CRC cis rs9381040 0.655 rs879491 chr6:41026953 A/G cg04346459 chr6:41068666 NFYA;LOC221442 -0.42 -6.29 -0.33 1.03e-9 Alzheimer's disease (late onset); CRC cis rs8180040 0.966 rs11925823 chr3:47443065 C/G cg27129171 chr3:47204927 SETD2 0.52 8.07 0.41 1.38e-14 Colorectal cancer; CRC cis rs2880765 0.805 rs34598679 chr15:86042205 G/A cg17133734 chr15:86042851 AKAP13 0.42 6.76 0.35 6.22e-11 Coronary artery disease; CRC cis rs11758351 0.866 rs77889957 chr6:26207435 A/G cg22723502 chr6:26240528 HIST1H4F -0.37 -6.21 -0.32 1.58e-9 Gout;Renal underexcretion gout; CRC cis rs1878931 0.501 rs37800 chr16:3423648 T/G cg26668626 chr16:3451006 ZNF174;ZNF434 -0.71 -9.81 -0.48 4.26e-20 Body mass index (adult); CRC cis rs6076065 0.676 rs4813490 chr20:23325150 A/G cg11657817 chr20:23433608 CST11 0.44 6.63 0.34 1.35e-10 Facial morphology (factor 15, philtrum width); CRC cis rs798554 0.679 rs1636254 chr7:2885724 T/C cg13628971 chr7:2884303 GNA12 0.63 8.88 0.44 4.29e-17 Height; CRC cis rs11864453 0.928 rs3213420 chr16:72042433 C/T cg01557791 chr16:72042693 DHODH -0.55 -7.87 -0.4 5.1e-14 Fibrinogen levels; CRC cis rs9560113 0.622 rs4773388 chr13:112195250 A/C cg10483660 chr13:112241077 NA 0.52 9.66 0.47 1.35e-19 Menarche (age at onset); CRC cis rs9322817 0.715 rs6918700 chr6:105244526 A/T cg02098413 chr6:105308735 HACE1 -0.43 -8.46 -0.42 8.65e-16 Thyroid stimulating hormone; CRC cis rs5769707 0.967 rs1018812 chr22:50010073 C/T cg10356904 chr22:49881777 NA -0.32 -6.0 -0.31 5.11e-9 Monocyte count;Monocyte percentage of white cells; CRC trans rs1728785 1.000 rs1182968 chr16:68573945 C/T cg04657470 chr2:198365150 HSPE1;HSPD1 0.58 7.0 0.36 1.46e-11 Ulcerative colitis; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg05470809 chr4:175205489 KIAA1712;FBXO8 0.48 6.79 0.35 5.19e-11 Response to antipsychotic treatment; CRC cis rs6964587 0.869 rs401 chr7:91527945 T/G cg17063962 chr7:91808500 NA -0.74 -12.25 -0.56 1.1e-28 Breast cancer; CRC cis rs9467160 0.559 rs2753911 chr6:24442288 C/T cg20631270 chr6:24437470 GPLD1 0.58 10.01 0.48 9.02e-21 Liver enzyme levels; CRC cis rs35306767 0.903 rs11253485 chr10:919362 C/T cg26597838 chr10:835615 NA 0.97 12.04 0.55 6.75e-28 Eosinophil percentage of granulocytes; CRC cis rs6570726 0.791 rs4335004 chr6:145904764 G/A cg23711669 chr6:146136114 FBXO30 0.76 13.02 0.58 1.55e-31 Lobe attachment (rater-scored or self-reported); CRC cis rs72772090 0.539 rs116360011 chr5:96117797 T/C cg17330273 chr5:96107758 CAST;ERAP1 -0.63 -5.77 -0.3 1.79e-8 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs1008375 1.000 rs2315561 chr4:17679695 C/T cg04450456 chr4:17643702 FAM184B 0.39 6.18 0.32 1.9e-9 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs6495122 0.501 rs8039755 chr15:75337426 T/C cg09165964 chr15:75287851 SCAMP5 -0.5 -7.6 -0.39 3.08e-13 Caffeine consumption;Diastolic blood pressure;Coffee consumption; CRC trans rs11148252 0.532 rs9536185 chr13:53179801 G/A cg18335740 chr13:41363409 SLC25A15 0.93 17.41 0.69 1.36e-48 Lewy body disease; CRC cis rs2836950 0.545 rs2297256 chr21:40558421 C/T cg11890956 chr21:40555474 PSMG1 -0.65 -9.91 -0.48 1.94e-20 Menarche (age at onset); CRC trans rs2727020 0.523 rs7948958 chr11:49506749 G/A cg15704280 chr7:45808275 SEPT13 0.74 9.62 0.47 1.75e-19 Coronary artery disease; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg00236302 chr12:69004867 RAP1B -0.43 -6.14 -0.32 2.43e-9 Myopia (pathological); CRC cis rs4588572 0.644 rs7714871 chr5:77754268 G/T cg11446398 chr5:77624930 NA 0.43 6.12 0.32 2.59e-9 Triglycerides; CRC cis rs875971 0.545 rs2420456 chr7:65745606 T/G cg03233332 chr7:66118400 NA -0.44 -6.11 -0.32 2.78e-9 Aortic root size; CRC cis rs769267 0.930 rs7254748 chr19:19397479 A/C cg20644253 chr19:19431407 KIAA0892;SF4 0.42 5.88 0.31 1.01e-8 Tonsillectomy; CRC cis rs13256369 0.774 rs11777719 chr8:8581038 A/G cg06671706 chr8:8559999 CLDN23 0.49 7.22 0.37 3.7e-12 Obesity-related traits; CRC cis rs9914988 0.943 rs11652272 chr17:27167973 C/G cg07195577 chr17:27052828 TLCD1 0.41 5.79 0.3 1.66e-8 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs801193 1.000 rs7789184 chr7:66210195 A/T cg05627663 chr7:65219948 SNORA22;CCT6P1 0.42 6.12 0.32 2.65e-9 Aortic root size; CRC cis rs10791323 0.517 rs1120247 chr11:133745180 T/G cg15485101 chr11:133734466 NA 0.39 7.16 0.37 5.45e-12 Childhood ear infection; CRC cis rs12135062 0.851 rs2651926 chr1:3101820 C/T cg25382214 chr1:3105252 PRDM16 -0.44 -7.13 -0.37 6.48e-12 Migraine; CRC cis rs2019137 0.936 rs12620738 chr2:113963739 C/T cg19083407 chr2:113993142 PAX8;LOC440839;LOC654433 -0.47 -6.68 -0.35 1.02e-10 Lymphocyte counts; CRC cis rs12586317 0.547 rs2038254 chr14:35462134 C/T cg16230307 chr14:35515116 FAM177A1 0.85 10.08 0.49 5.15e-21 Psoriasis; CRC cis rs8180040 0.966 rs12636851 chr3:47463567 C/T cg10298567 chr3:47292165 KIF9 -0.39 -6.21 -0.32 1.56e-9 Colorectal cancer; CRC cis rs2228479 0.850 rs12598276 chr16:89829196 G/C cg19635926 chr16:89946313 TCF25 0.63 5.68 0.3 3.01e-8 Skin colour saturation; CRC cis rs2303759 0.709 rs10414921 chr19:49823047 C/T cg22133161 chr19:49891603 CCDC155 0.51 6.65 0.34 1.21e-10 Multiple sclerosis; CRC cis rs11098499 0.575 rs907205 chr4:120238664 G/C cg24375607 chr4:120327624 NA 0.48 7.64 0.39 2.32e-13 Corneal astigmatism; CRC cis rs6952808 0.964 rs10950400 chr7:1882470 C/T cg00106254 chr7:1943704 MAD1L1 -0.42 -5.91 -0.31 8.45e-9 Bipolar disorder and schizophrenia; CRC cis rs2882667 0.931 rs10075951 chr5:138355963 G/T cg04439458 chr5:138467593 SIL1 -0.32 -5.82 -0.31 1.37e-8 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs7447593 0.626 rs3812036 chr5:176813404 C/T cg17509989 chr5:176798049 RGS14 0.75 11.63 0.54 1.97e-26 Urinary electrolytes (magnesium/calcium ratio); CRC cis rs7833790 0.685 rs13255262 chr8:82728024 T/G cg17211192 chr8:82754475 SNX16 -0.47 -6.67 -0.35 1.08e-10 Diastolic blood pressure; CRC cis rs736801 0.780 rs2188962 chr5:131770805 C/T cg14196790 chr5:131705035 SLC22A5 0.35 5.72 0.3 2.42e-8 Breast cancer;Mosquito bite size; CRC cis rs4700695 1.000 rs153319 chr5:65419423 C/T cg21114390 chr5:65439923 SFRS12 -0.51 -6.0 -0.31 5.13e-9 Facial morphology (factor 19); CRC cis rs6060987 1 rs6060987 chr20:30427077 T/A cg13852791 chr20:30311386 BCL2L1 0.64 10.14 0.49 3.2e-21 Mean corpuscular volume; CRC cis rs7666738 0.830 rs28451101 chr4:99001190 T/C cg17366294 chr4:99064904 C4orf37 0.44 7.39 0.38 1.19e-12 Colonoscopy-negative controls vs population controls; CRC cis rs1552244 1.000 rs35741213 chr3:10087661 A/G cg00166722 chr3:10149974 C3orf24 0.7 9.53 0.46 3.69e-19 Alzheimer's disease; CRC trans rs11098499 0.754 rs938056 chr4:120237453 C/T cg25214090 chr10:38739885 LOC399744 0.53 8.41 0.42 1.24e-15 Corneal astigmatism; CRC cis rs6952808 0.792 rs13224989 chr7:1953766 C/G cg04267008 chr7:1944627 MAD1L1 -0.79 -11.86 -0.55 3.05e-27 Bipolar disorder and schizophrenia; CRC cis rs2050392 0.767 rs10763786 chr10:30693567 G/C cg18806716 chr10:30721971 MAP3K8 0.7 10.11 0.49 4.35e-21 Inflammatory bowel disease; CRC cis rs7618915 0.547 rs13069481 chr3:52666866 C/T cg18099408 chr3:52552593 STAB1 -0.44 -7.13 -0.37 6.36e-12 Bipolar disorder; CRC cis rs9303280 0.806 rs9909593 chr17:37970149 C/T cg11212589 chr17:38028394 ZPBP2 -0.37 -6.76 -0.35 6.45e-11 Self-reported allergy; CRC cis rs4713118 0.513 rs156739 chr6:28013410 C/A cg25164649 chr6:28176230 NA 0.59 8.43 0.42 1.14e-15 Parkinson's disease; CRC cis rs3772130 0.545 rs7340674 chr3:121574215 T/C cg20356878 chr3:121714668 ILDR1 0.56 10.76 0.51 2.48e-23 Cognitive performance; CRC cis rs7385804 0.761 rs568733 chr7:100311662 G/T cg20848291 chr7:100343083 ZAN 0.48 7.35 0.38 1.55e-12 Iron status biomarkers;Mean corpuscular hemoglobin;Hematocrit;Iron status biomarkers (transferrin saturation);Red blood cell count;Iron status biomarkers (iron levels);Mean corpuscular volume;Hematological parameters; CRC cis rs758324 0.947 rs2404778 chr5:131172886 T/C cg25547332 chr5:131281432 NA 0.38 5.75 0.3 2.01e-8 Alzheimer's disease in APOE e4- carriers; CRC cis rs4689388 0.824 rs4467645 chr4:6294305 C/T cg14416269 chr4:6271139 WFS1 0.4 6.59 0.34 1.72e-10 Type 2 diabetes and other traits;Type 2 diabetes; CRC trans rs9393777 0.778 rs74689501 chr6:26887821 G/A cg06606381 chr12:133084897 FBRSL1 -1.04 -7.49 -0.38 6.29e-13 Intelligence (multi-trait analysis); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg07556773 chr1:155294010 RUSC1;C1orf104 0.4 6.12 0.32 2.63e-9 Intelligence (multi-trait analysis); CRC cis rs9916302 0.861 rs2338801 chr17:37490780 G/T cg15445000 chr17:37608096 MED1 -0.41 -8.99 -0.44 2.02e-17 Glomerular filtration rate (creatinine); CRC cis rs2179367 0.959 rs489551 chr6:149689457 A/G cg11245181 chr6:149772854 ZC3H12D -0.4 -6.16 -0.32 2.06e-9 Dupuytren's disease; CRC cis rs2415984 0.622 rs61993302 chr14:46949684 C/T cg14871534 chr14:47121158 RPL10L -0.45 -6.37 -0.33 6.21e-10 Number of children ever born; CRC cis rs12760731 0.641 rs11590951 chr1:178322757 C/T cg00404053 chr1:178313656 RASAL2 0.94 9.89 0.48 2.37e-20 Obesity-related traits; CRC cis rs11758351 1.000 rs2143347 chr6:26198494 C/T cg01420254 chr6:26195488 NA 0.85 8.96 0.44 2.4e-17 Gout;Renal underexcretion gout; CRC cis rs7412746 0.552 rs4970980 chr1:150864992 A/C cg10589385 chr1:150898437 SETDB1 0.28 6.07 0.32 3.43e-9 Melanoma; CRC cis rs4713118 0.869 rs9283882 chr6:27715258 A/C cg03623178 chr6:28175578 NA 0.67 9.51 0.46 4.25e-19 Parkinson's disease; CRC cis rs2115630 0.645 rs3825878 chr15:85174755 C/T cg11189052 chr15:85197271 WDR73 -0.68 -11.51 -0.54 5.59e-26 P wave terminal force; CRC cis rs35995292 0.534 rs2008199 chr7:38939678 T/C cg19327137 chr7:38886074 VPS41 0.69 11.49 0.54 6.25e-26 Subjective well-being (multi-trait analysis); CRC cis rs17376456 0.569 rs7729807 chr5:93104089 C/T cg25358565 chr5:93447407 FAM172A 0.63 7.31 0.37 2.02e-12 Diabetic retinopathy; CRC cis rs736408 0.505 rs2083180 chr3:52668119 G/T cg05573699 chr3:52720067 GNL3;PBRM1 -0.47 -6.97 -0.36 1.69e-11 Bipolar disorder; CRC cis rs4974559 0.948 rs3856982 chr4:1328863 C/T cg02980000 chr4:1222292 CTBP1 -0.52 -6.69 -0.35 9.32e-11 Systolic blood pressure; CRC trans rs9291683 0.588 rs3756236 chr4:10013463 T/A cg26043149 chr18:55253948 FECH 0.51 7.91 0.4 3.95e-14 Bone mineral density; CRC cis rs2404602 0.532 rs206205 chr15:76736091 T/G cg03037974 chr15:76606532 NA 0.57 9.58 0.47 2.41e-19 Blood metabolite levels; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg13770088 chr11:32851361 PRRG4 0.45 6.89 0.36 2.84e-11 Intelligence (multi-trait analysis); CRC cis rs4363385 0.818 rs1415965 chr1:153002750 G/A cg25856811 chr1:152973957 SPRR3 -0.26 -7.16 -0.37 5.44e-12 Inflammatory skin disease; CRC cis rs883565 0.655 rs4645092 chr3:39051718 G/A cg01426195 chr3:39028469 NA -0.53 -8.56 -0.43 4.39e-16 Handedness; CRC cis rs10256972 1.000 rs10256972 chr7:1039003 G/T cg07930192 chr7:1003750 NA -0.42 -6.62 -0.34 1.5e-10 Longevity;Endometriosis; CRC cis rs7647973 0.516 rs12490393 chr3:49196132 C/T cg06212747 chr3:49208901 KLHDC8B 0.38 5.61 0.3 4.26e-8 Menarche (age at onset); CRC cis rs9309473 0.687 rs6748040 chr2:73609928 A/G cg20560298 chr2:73613845 ALMS1 0.51 7.18 0.37 4.61e-12 Metabolite levels; CRC cis rs2153535 0.542 rs4440510 chr6:8471818 C/T cg21535247 chr6:8435926 SLC35B3 0.51 7.76 0.39 1.11e-13 Motion sickness; CRC cis rs1953600 0.870 rs1049550 chr10:81926702 G/A cg04850286 chr10:81895943 PLAC9 -0.37 -6.67 -0.35 1.06e-10 Sarcoidosis; CRC cis rs9322193 0.923 rs9322209 chr6:150012362 A/G cg13206674 chr6:150067644 NUP43 0.65 9.66 0.47 1.3e-19 Lung cancer; CRC cis rs9992667 0.955 rs73232881 chr4:38664131 T/C cg19726192 chr4:38663646 FLJ13197 -0.71 -8.79 -0.44 8.56e-17 Eosinophil percentage of granulocytes; CRC cis rs138880 0.580 rs28562884 chr22:50312869 T/C cg22709217 chr22:50311962 ALG12;CRELD2 -1.02 -10.18 -0.49 2.47e-21 Schizophrenia; CRC cis rs477895 0.713 rs7952318 chr11:63961242 G/A cg23719950 chr11:63933701 MACROD1 -0.61 -8.04 -0.41 1.59e-14 Mean platelet volume; CRC cis rs13256369 1.000 rs13267501 chr8:8574058 G/A cg06671706 chr8:8559999 CLDN23 0.55 8.31 0.42 2.5e-15 Obesity-related traits; CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg18876457 chr1:160071037 NA -0.53 -6.47 -0.34 3.6e-10 Diisocyanate-induced asthma; CRC cis rs9467603 0.925 rs1892253 chr6:25782314 G/T cg08501292 chr6:25962987 TRIM38 0.61 5.9 0.31 9.2e-9 Intelligence (multi-trait analysis); CRC cis rs711245 0.573 rs3770796 chr2:36799515 T/C cg01206211 chr2:36825736 FEZ2 0.45 7.13 0.37 6.23e-12 Height; CRC trans rs5756813 0.754 rs4820307 chr22:38175955 G/A cg19894588 chr14:64061835 NA -0.54 -7.2 -0.37 4.07e-12 Optic cup area;Vertical cup-disc ratio; CRC cis rs10751667 0.621 rs7396049 chr11:1001561 G/A ch.11.42038R chr11:967971 AP2A2 0.54 8.69 0.43 1.74e-16 Alzheimer's disease (late onset); CRC trans rs7647973 0.593 rs1799844 chr3:49847642 G/A cg21659725 chr3:3221576 CRBN 0.62 6.51 0.34 2.86e-10 Menarche (age at onset); CRC cis rs10883723 0.773 rs11191313 chr10:104278618 C/T cg04362960 chr10:104952993 NT5C2 -0.42 -5.68 -0.3 2.94e-8 Allergic disease (asthma, hay fever or eczema); CRC cis rs28386778 0.863 rs2251164 chr17:61884120 G/A cg07362569 chr17:61921086 SMARCD2 0.39 5.99 0.31 5.59e-9 Prudent dietary pattern; CRC cis rs4728302 0.643 rs6966335 chr7:133702217 C/T cg03336402 chr7:133662267 EXOC4 -0.44 -6.76 -0.35 6.25e-11 Intelligence;Intelligence (multi-trait analysis); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg04117832 chr2:152685230 ARL5A 0.41 6.63 0.34 1.39e-10 Liver disease severity in Alagille syndrome; CRC cis rs6570726 0.791 rs1280275 chr6:145892402 C/T cg05347473 chr6:146136440 FBXO30 0.38 5.85 0.31 1.18e-8 Lobe attachment (rater-scored or self-reported); CRC trans rs944990 0.595 rs10123378 chr9:96375217 C/T cg07574458 chr4:17513646 QDPR 0.37 6.04 0.32 4.26e-9 Body mass index; CRC cis rs2204008 0.571 rs1117803 chr12:38281007 C/G cg26384229 chr12:38710491 ALG10B -0.51 -7.44 -0.38 8.74e-13 Bladder cancer; CRC trans rs10411161 0.810 rs17778711 chr19:52385300 A/G cg22319618 chr22:45562946 NUP50 -0.67 -6.21 -0.32 1.63e-9 Breast cancer; CRC cis rs2268241 0.938 rs28653198 chr21:34782395 A/C cg14850771 chr21:34775459 IFNGR2 0.77 9.64 0.47 1.6e-19 Obesity-related traits; CRC cis rs755249 0.567 rs72661927 chr1:39675322 A/G cg18385671 chr1:39797026 MACF1 -0.44 -6.34 -0.33 7.8e-10 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs13256369 0.755 rs12680167 chr8:8562467 A/G cg06636001 chr8:8085503 FLJ10661 0.5 6.3 0.33 9.68e-10 Obesity-related traits; CRC cis rs4555082 0.957 rs2816622 chr14:105733114 T/C cg06808227 chr14:105710500 BRF1 -0.61 -9.12 -0.45 7.57e-18 Mean platelet volume;Platelet distribution width; CRC cis rs1218582 0.774 rs4845680 chr1:154863195 A/G cg06221963 chr1:154839813 KCNN3 -0.78 -15.86 -0.66 1.71e-42 Prostate cancer; CRC cis rs2991971 0.934 rs2991974 chr1:46020654 A/G cg24296786 chr1:45957014 TESK2 0.51 7.2 0.37 4.11e-12 High light scatter reticulocyte count; CRC cis rs514406 0.929 rs515857 chr1:53336859 A/G cg27535305 chr1:53392650 SCP2 -0.37 -6.8 -0.35 4.82e-11 Monocyte count; CRC cis rs853679 0.760 rs9368563 chr6:28208558 A/G cg15786705 chr6:28176104 NA 0.62 6.67 0.34 1.11e-10 Depression; CRC cis rs2019137 0.901 rs4849176 chr2:113977936 C/T cg11763394 chr2:113992921 PAX8;LOC440839;LOC654433 -0.49 -7.07 -0.36 9.11e-12 Lymphocyte counts; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg05367824 chr21:40817657 SH3BGR 0.44 6.26 0.33 1.18e-9 Anxiety disorder; CRC cis rs911119 0.913 rs13038990 chr20:23589053 C/T cg16589663 chr20:23618590 CST3 0.44 6.29 0.33 9.89e-10 Chronic kidney disease; CRC cis rs7247513 0.964 rs8100964 chr19:12720631 C/T cg01871581 chr19:12707946 ZNF490 -0.82 -13.57 -0.6 1.26e-33 Bipolar disorder; CRC cis rs7811142 1.000 rs113738841 chr7:100081306 C/T cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.08 15.27 0.64 3.58e-40 Platelet count; CRC cis rs7618915 0.547 rs13085895 chr3:52678270 G/C cg10802521 chr3:52805072 NEK4 -0.58 -9.0 -0.44 1.8e-17 Bipolar disorder; CRC cis rs7223966 1.000 rs7209758 chr17:61913621 C/T cg23090583 chr17:61904693 PSMC5;FTSJ3 0.55 6.88 0.35 3.08e-11 Hip circumference adjusted for BMI;Body mass index; CRC cis rs7085104 0.572 rs284857 chr10:104574063 C/T cg04362960 chr10:104952993 NT5C2 -0.56 -8.4 -0.42 1.38e-15 Immature fraction of reticulocytes;Schizophrenia; CRC cis rs939584 0.825 rs4423631 chr2:648758 T/C cg03610516 chr2:642275 NA 0.42 5.85 0.31 1.2e-8 Body mass index; CRC cis rs2645694 0.626 rs2703124 chr4:77820626 G/T cg18351406 chr4:77819688 ANKRD56 0.5 7.53 0.38 5e-13 Emphysema distribution in smoking; CRC cis rs7727544 1.000 rs10076701 chr5:131596419 A/G cg22638593 chr5:131593259 PDLIM4 0.39 7.71 0.39 1.49e-13 Blood metabolite levels; CRC trans rs2413583 0.591 rs76449672 chr22:39696482 G/A cg09612413 chr10:12085555 UPF2 -0.56 -6.21 -0.32 1.58e-9 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; CRC cis rs8141529 0.748 rs5997412 chr22:29276747 G/A cg02153584 chr22:29168773 CCDC117 0.47 6.83 0.35 4.19e-11 Lymphocyte counts; CRC cis rs2456568 0.802 rs1574515 chr11:93629643 T/C cg26875233 chr11:93583750 C11orf90 -0.33 -6.54 -0.34 2.33e-10 Response to serotonin reuptake inhibitors in major depressive disorder; CRC cis rs4969178 0.965 rs3817294 chr17:76396963 A/G cg05887092 chr17:76393375 PGS1 0.55 10.0 0.48 1.01e-20 HDL cholesterol levels; CRC cis rs62408225 1.000 rs943689 chr6:90984035 C/T cg06866423 chr6:90926672 BACH2 0.48 8.03 0.4 1.74e-14 Eosinophil counts;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC cis rs12325245 0.536 rs12925676 chr16:58625326 C/T cg21335942 chr16:58549945 SETD6 0.86 5.72 0.3 2.39e-8 Schizophrenia; CRC cis rs10479542 0.752 rs12658664 chr5:178986987 C/T cg21226059 chr5:178986404 RUFY1 0.38 6.77 0.35 5.91e-11 Lung cancer; CRC cis rs7727544 0.901 rs55633655 chr5:131598756 T/G cg22638593 chr5:131593259 PDLIM4 0.35 6.79 0.35 5.38e-11 Blood metabolite levels; CRC trans rs8002861 0.846 rs12869355 chr13:44478193 A/C cg17145862 chr1:211918768 LPGAT1 0.68 12.17 0.56 2.11e-28 Leprosy; CRC trans rs57221529 0.766 rs4081846 chr5:574019 G/A cg11887960 chr12:57824829 NA 0.61 6.72 0.35 7.84e-11 Lung disease severity in cystic fibrosis; CRC cis rs67478160 0.634 rs2144080 chr14:104258761 A/C cg08213375 chr14:104286397 PPP1R13B 0.58 11.91 0.55 1.87e-27 Schizophrenia; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg23978161 chr4:77870897 SEPT11 -0.41 -6.15 -0.32 2.2e-9 Myopia (pathological); CRC cis rs910316 0.967 rs12147532 chr14:75651858 T/G cg08847533 chr14:75593920 NEK9 -0.87 -14.92 -0.64 8.13e-39 Height; CRC cis rs12762955 0.561 rs6560863 chr10:1013535 C/A cg26597838 chr10:835615 NA -0.41 -5.64 -0.3 3.58e-8 Response to angiotensin II receptor blocker therapy; CRC cis rs12431939 0.948 rs12433249 chr14:51669661 T/C cg23942311 chr14:51606299 NA -0.5 -6.36 -0.33 6.9e-10 Cancer; CRC cis rs34172651 0.517 rs11647120 chr16:24819806 A/G cg04756594 chr16:24857601 SLC5A11 0.31 6.41 0.33 5.11e-10 Intelligence (multi-trait analysis); CRC trans rs11098499 0.779 rs10857066 chr4:120286596 C/T cg25214090 chr10:38739885 LOC399744 0.61 9.6 0.47 2.17e-19 Corneal astigmatism; CRC trans rs2727020 0.556 rs2866365 chr11:49390731 A/G cg15704280 chr7:45808275 SEPT13 -0.75 -9.54 -0.47 3.37e-19 Coronary artery disease; CRC trans rs9784649 1.000 rs56004901 chr5:24998968 A/G cg08600765 chr20:34638493 LOC647979 -0.62 -7.47 -0.38 7.09e-13 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs2898681 0.739 rs1047959 chr4:53739856 C/G cg00338735 chr4:53728038 RASL11B 0.37 5.62 0.3 4.04e-8 Optic nerve measurement (cup area); CRC cis rs1878931 0.559 rs2106863 chr16:3391330 T/C cg26668626 chr16:3451006 ZNF174;ZNF434 0.51 7.02 0.36 1.29e-11 Body mass index (adult); CRC cis rs2075371 1.000 rs2598286 chr7:133976029 G/A cg20476274 chr7:133979776 SLC35B4 0.81 14.84 0.63 1.62e-38 Mean platelet volume; CRC cis rs7777754 0.512 rs11238131 chr7:50538589 T/C cg14593290 chr7:50529359 DDC -0.52 -7.72 -0.39 1.37e-13 Response to zileuton treatment in asthma (FEV1 change interaction); CRC cis rs7586879 0.789 rs17046737 chr2:25127835 C/T cg22495460 chr2:25135724 ADCY3 -0.88 -15.19 -0.64 7.27e-40 Body mass index; CRC cis rs870825 0.616 rs7700216 chr4:185648510 G/T cg04058563 chr4:185651563 MLF1IP 0.72 9.3 0.46 2.04e-18 Blood protein levels; CRC cis rs853679 0.517 rs35227624 chr6:28132726 A/G cg02683197 chr6:28174875 NA 0.87 10.73 0.51 3.25e-23 Depression; CRC cis rs2070488 0.932 rs1841776 chr3:38480727 C/T cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.91 16.81 0.68 3.44e-46 Electrocardiographic conduction measures; CRC trans rs3960554 0.610 rs11971800 chr7:75731608 C/T cg19862616 chr7:65841803 NCRNA00174 0.66 7.94 0.4 3.13e-14 Eotaxin levels; CRC cis rs4713118 0.786 rs200502 chr6:27788062 C/T cg20933634 chr6:27740509 NA 0.62 8.21 0.41 5.17e-15 Parkinson's disease; CRC cis rs826838 0.616 rs9668847 chr12:38614669 C/T cg26384229 chr12:38710491 ALG10B 0.43 6.25 0.33 1.26e-9 Heart rate; CRC cis rs172166 0.516 rs2622322 chr6:28117443 C/G cg02683197 chr6:28174875 NA 0.47 6.65 0.34 1.24e-10 Cardiac Troponin-T levels; CRC cis rs6570726 1.000 rs436066 chr6:145847127 C/T cg13319975 chr6:146136371 FBXO30 -0.38 -5.77 -0.3 1.79e-8 Lobe attachment (rater-scored or self-reported); CRC cis rs11608355 0.521 rs4766469 chr12:109836890 C/G cg19025524 chr12:109796872 NA 0.56 8.96 0.44 2.43e-17 Neuroticism; CRC cis rs9747201 1.000 rs56051385 chr17:80126712 T/C cg14673194 chr17:80132900 CCDC57 0.49 6.42 0.33 4.73e-10 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs6502050 0.635 rs9889327 chr17:80087839 G/A cg09264619 chr17:80180166 NA -0.36 -6.09 -0.32 3.09e-9 Life satisfaction; CRC cis rs6963495 0.818 rs117028299 chr7:105162310 T/C cg13798780 chr7:105162888 PUS7 0.68 8.08 0.41 1.27e-14 Bipolar disorder (body mass index interaction); CRC cis rs763121 0.853 rs2072796 chr22:39064230 A/G cg06022373 chr22:39101656 GTPBP1 0.8 12.64 0.57 3.9e-30 Menopause (age at onset); CRC cis rs9463078 0.691 rs12194311 chr6:45329048 C/A cg25276700 chr6:44698697 NA 0.24 5.84 0.31 1.26e-8 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; CRC cis rs6582630 0.502 rs11520278 chr12:38359642 T/A cg26384229 chr12:38710491 ALG10B 0.69 9.24 0.45 3.04e-18 Drug-induced liver injury (flucloxacillin); CRC trans rs61931739 0.534 rs10844728 chr12:34020109 G/C cg26384229 chr12:38710491 ALG10B 0.54 6.86 0.35 3.33e-11 Morning vs. evening chronotype; CRC cis rs9914988 0.943 rs7215000 chr17:27088436 C/T cg12682573 chr17:27188876 MIR451;MIR144 0.58 7.99 0.4 2.34e-14 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs116095464 0.542 rs28650039 chr5:273954 C/A cg22496380 chr5:211416 CCDC127 -0.91 -10.37 -0.5 5.27e-22 Breast cancer; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg07822613 chr19:1875079 NA 0.44 6.43 0.33 4.41e-10 Response to antipsychotic treatment; CRC cis rs8060686 0.858 rs7196789 chr16:67927124 C/T cg01951491 chr16:67709440 GFOD2 -0.45 -5.94 -0.31 7.37e-9 HDL cholesterol;Metabolic syndrome; CRC cis rs514406 0.861 rs11206011 chr1:53235910 T/C cg08859206 chr1:53392774 SCP2 0.43 6.89 0.36 2.82e-11 Monocyte count; CRC cis rs12898370 0.561 rs34129891 chr15:77481210 T/C cg05673287 chr15:77411982 SGK269 -0.54 -5.81 -0.31 1.46e-8 Risky sexual behaviors (alcohol dependence interaction); CRC cis rs736408 0.688 rs2239551 chr3:52818579 A/G cg07507251 chr3:52567010 NT5DC2 -0.45 -6.36 -0.33 6.94e-10 Bipolar disorder; CRC cis rs972578 1.000 rs2016623 chr22:43370549 A/G cg01576275 chr22:43409880 NA -0.45 -7.28 -0.37 2.47e-12 Mean platelet volume; CRC cis rs1451375 0.698 rs11489734 chr7:50635730 A/T cg14593290 chr7:50529359 DDC 0.49 6.92 0.36 2.42e-11 Malaria; CRC cis rs8180040 0.932 rs62246474 chr3:47398130 C/T cg02527881 chr3:46936655 PTH1R 0.39 7.1 0.36 7.8e-12 Colorectal cancer; CRC cis rs6499255 0.951 rs57488237 chr16:69741571 T/C cg15192750 chr16:69999425 NA 0.55 7.49 0.38 6.37e-13 IgE levels; CRC cis rs4819052 0.851 rs7275874 chr21:46671223 C/T cg02159808 chr21:46707872 POFUT2;LOC642852 0.49 6.54 0.34 2.4e-10 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg09068198 chr2:65357064 RAB1A 0.44 5.99 0.31 5.53e-9 Response to antipsychotic treatment; CRC cis rs7572644 0.640 rs9678336 chr2:28065404 A/G cg27432699 chr2:27873401 GPN1 0.45 6.11 0.32 2.79e-9 Response to carboplatin and paclitaxel in ovarian cancer (Caspase 3/7 EC50); CRC cis rs17376456 0.825 rs10064368 chr5:93266396 C/A cg09848695 chr5:92956644 FAM172A;MIR2277 0.68 6.03 0.32 4.45e-9 Diabetic retinopathy; CRC cis rs921968 0.541 rs12619347 chr2:219419935 T/C cg02176678 chr2:219576539 TTLL4 -0.61 -9.68 -0.47 1.15e-19 Mean corpuscular hemoglobin concentration; CRC cis rs9309473 0.579 rs1852644 chr2:73597718 A/G cg20560298 chr2:73613845 ALMS1 -0.5 -6.93 -0.36 2.19e-11 Metabolite levels; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg14677014 chr10:15001504 MEIG1 -0.39 -6.05 -0.32 3.85e-9 Myopia (pathological); CRC cis rs7705042 0.897 rs4912807 chr5:141519296 G/C cg07392085 chr5:141489673 NDFIP1 0.45 7.25 0.37 2.94e-12 Asthma; CRC cis rs3806843 0.735 rs2530235 chr5:140072647 G/T cg16607685 chr5:140181889 PCDHA2;PCDHA1;PCDHA3 0.25 5.66 0.3 3.33e-8 Depressive symptoms (multi-trait analysis); CRC cis rs10504229 1.000 rs72650885 chr8:58175131 G/A cg02290350 chr8:58132656 NA -0.42 -5.96 -0.31 6.62e-9 Developmental language disorder (linguistic errors); CRC cis rs4969178 0.965 rs8071889 chr17:76398101 A/G cg05887092 chr17:76393375 PGS1 0.55 9.99 0.48 1.07e-20 HDL cholesterol levels; CRC cis rs2836950 0.502 rs2150411 chr21:40574552 G/T cg11890956 chr21:40555474 PSMG1 -0.68 -10.12 -0.49 4e-21 Menarche (age at onset); CRC cis rs1448094 0.511 rs7976647 chr12:86158766 A/G cg25456477 chr12:86230367 RASSF9 0.39 6.56 0.34 2.13e-10 Major depressive disorder; CRC cis rs7705042 0.727 rs1062158 chr5:141523000 C/T cg08523384 chr5:141488047 NDFIP1 -0.31 -5.68 -0.3 3.02e-8 Asthma; CRC cis rs4731207 0.596 rs10274513 chr7:124650537 T/C cg23710748 chr7:124431027 NA -0.39 -6.25 -0.33 1.24e-9 Cutaneous malignant melanoma; CRC cis rs11785400 1.000 rs6995314 chr8:143749718 A/G cg10596483 chr8:143751796 JRK -0.44 -6.14 -0.32 2.44e-9 Schizophrenia; CRC trans rs7809615 0.581 rs57980352 chr7:98985408 G/A cg19809667 chr19:54401945 PRKCG 0.6 5.99 0.31 5.43e-9 Blood metabolite ratios; CRC cis rs524281 0.861 rs10896080 chr11:65876796 G/A cg16950941 chr11:66035639 RAB1B -0.6 -7.44 -0.38 8.67e-13 Electroencephalogram traits; CRC cis rs77861329 1.000 rs876782 chr3:52107909 C/T cg08692210 chr3:52188851 WDR51A -0.87 -8.37 -0.42 1.63e-15 Macrophage inflammatory protein 1b levels; CRC cis rs10979 0.965 rs34373782 chr6:143888258 A/G cg25407410 chr6:143891975 LOC285740 -0.82 -13.4 -0.59 5.5e-33 Hypospadias; CRC cis rs8114671 0.562 rs2064454 chr20:33496169 C/T cg07148914 chr20:33460835 GGT7 0.46 7.28 0.37 2.55e-12 Height; CRC cis rs9381040 0.626 rs2272986 chr6:41037778 C/T cg04346459 chr6:41068666 NFYA;LOC221442 -0.42 -6.22 -0.32 1.49e-9 Alzheimer's disease (late onset); CRC cis rs861020 0.959 rs641348 chr1:209992043 A/G cg09163369 chr1:210001066 C1orf107 0.6 7.47 0.38 7.22e-13 Orofacial clefts; CRC cis rs908922 0.676 rs1538082 chr1:152517304 A/G cg23254163 chr1:152506842 NA 0.44 8.57 0.43 4.11e-16 Hair morphology; CRC cis rs9467711 0.606 rs72841536 chr6:26378288 T/A cg14345882 chr6:26364793 BTN3A2 0.71 6.06 0.32 3.68e-9 Autism spectrum disorder or schizophrenia; CRC cis rs910316 1.000 rs7142235 chr14:75559963 T/C cg08847533 chr14:75593920 NEK9 0.94 18.74 0.72 8.14e-54 Height; CRC cis rs2635047 1.000 rs2684841 chr18:44724262 C/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.45 7.33 0.37 1.85e-12 Educational attainment; CRC cis rs796364 1.000 rs281794 chr2:200846666 C/T cg12253985 chr2:200820533 C2orf60;C2orf47 0.58 6.3 0.33 9.76e-10 Schizophrenia; CRC cis rs9549367 0.789 rs57747440 chr13:113894750 C/A cg00898013 chr13:113819073 PROZ -0.45 -6.37 -0.33 6.54e-10 Platelet distribution width; CRC cis rs4750440 0.540 rs11258766 chr10:14016196 G/A cg00551146 chr10:14014579 FRMD4A 0.44 6.96 0.36 1.91e-11 Adiponectin levels; CRC cis rs7122539 0.646 rs594313 chr11:66608991 A/G cg24851651 chr11:66362959 CCS 0.51 9.72 0.47 8.52e-20 HIV-1 susceptibility; CRC cis rs75920871 0.528 rs7941428 chr11:116903384 C/G cg20608306 chr11:116969690 SIK3 -0.32 -6.12 -0.32 2.69e-9 Subjective well-being; CRC cis rs9611565 0.681 rs5751094 chr22:41803279 C/T cg03806693 chr22:41940476 POLR3H 0.99 12.39 0.56 3.48e-29 Vitiligo; CRC cis rs12594515 1.000 rs6493176 chr15:45990026 A/G cg01629716 chr15:45996671 NA 0.41 8.46 0.42 9.03e-16 Waist circumference;Weight; CRC cis rs55702914 0.650 rs6715690 chr2:198148371 C/T cg10820045 chr2:198174542 NA -0.38 -6.88 -0.35 3.04e-11 Major depression and alcohol dependence; CRC cis rs6502050 0.805 rs6502057 chr17:80082060 A/G cg19223190 chr17:80058835 NA -0.43 -6.77 -0.35 6.1e-11 Life satisfaction; CRC cis rs6952808 0.756 rs12537348 chr7:1948172 C/G cg20295408 chr7:1910781 MAD1L1 -0.43 -5.98 -0.31 5.88e-9 Bipolar disorder and schizophrenia; CRC cis rs4891159 0.548 rs2554830 chr18:74127702 A/G cg24786174 chr18:74118243 ZNF516 0.89 21.04 0.76 7.18e-63 Longevity; CRC cis rs6969780 1.000 rs73071550 chr7:27149099 T/C cg26364809 chr7:27145159 NA -0.72 -6.71 -0.35 8.56e-11 Diastolic blood pressure;Blood pressure traits (multi-trait analysis);Systolic blood pressure;Hypertension; CRC cis rs798554 0.757 rs1182176 chr7:2874601 A/G cg13628971 chr7:2884303 GNA12 0.49 6.8 0.35 5.04e-11 Height; CRC cis rs2456568 0.543 rs4144616 chr11:93621900 A/G cg26875233 chr11:93583750 C11orf90 -0.35 -6.71 -0.35 8.35e-11 Response to serotonin reuptake inhibitors in major depressive disorder; CRC cis rs4363385 0.818 rs12195 chr1:153004983 C/T cg25856811 chr1:152973957 SPRR3 -0.24 -6.34 -0.33 7.66e-10 Inflammatory skin disease; CRC cis rs7635838 0.892 rs6442252 chr3:11451416 T/C cg00170343 chr3:11313890 ATG7 0.38 5.75 0.3 2.04e-8 HDL cholesterol; CRC cis rs3849570 0.925 rs6798680 chr3:81905441 C/A cg07356753 chr3:81810745 GBE1 -0.65 -9.51 -0.46 4.2e-19 Waist circumference;Body mass index; CRC cis rs6662572 0.737 rs7525281 chr1:46267923 A/G cg08644498 chr1:46502608 NA -0.44 -7.0 -0.36 1.4e-11 Blood protein levels; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg07150538 chr10:111970028 MXI1 0.47 6.01 0.31 4.87e-9 Thyroid stimulating hormone; CRC trans rs2313132 0.722 rs7434478 chr4:138598984 A/G cg16556111 chr5:92918829 NR2F1 -0.57 -6.01 -0.31 4.93e-9 Systemic lupus erythematosus; CRC cis rs1005277 0.579 rs2472181 chr10:38386764 T/C cg25517755 chr10:38738941 LOC399744 -0.44 -6.41 -0.33 5.05e-10 Extrinsic epigenetic age acceleration; CRC cis rs4072980 0.545 rs12120737 chr1:38422544 C/T cg12658694 chr1:38397304 INPP5B 0.5 7.33 0.37 1.85e-12 Coronary artery disease; CRC cis rs9649213 0.555 rs6955259 chr7:97892356 T/A cg21770322 chr7:97807741 LMTK2 0.58 9.54 0.47 3.29e-19 Prostate cancer (SNP x SNP interaction); CRC cis rs9322193 0.962 rs4380763 chr6:149999222 A/G cg05861140 chr6:150128134 PCMT1 -0.37 -5.93 -0.31 7.62e-9 Lung cancer; CRC cis rs6499255 1.000 rs4580150 chr16:69814953 G/A cg00738113 chr16:70207722 CLEC18C -0.43 -6.2 -0.32 1.71e-9 IgE levels; CRC cis rs853679 0.546 rs200949 chr6:27835435 A/G cg12273811 chr6:28175739 NA 0.64 6.4 0.33 5.26e-10 Depression; CRC cis rs1059312 0.808 rs2170989 chr12:129291317 T/C cg09035930 chr12:129282057 SLC15A4 -0.53 -8.86 -0.44 5e-17 Systemic lupus erythematosus; CRC cis rs10256972 0.621 rs10951594 chr7:1088607 C/G cg02869364 chr7:1081709 C7orf50 -0.42 -6.83 -0.35 4.11e-11 Longevity;Endometriosis; CRC cis rs6952808 0.756 rs12537348 chr7:1948172 C/G cg22963979 chr7:1858916 MAD1L1 -0.52 -7.73 -0.39 1.32e-13 Bipolar disorder and schizophrenia; CRC trans rs916888 0.821 rs199509 chr17:44858728 G/A cg10053473 chr17:62856997 LRRC37A3 0.71 8.39 0.42 1.42e-15 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs2153535 0.580 rs9406169 chr6:8509470 A/T cg07606381 chr6:8435919 SLC35B3 0.66 10.61 0.5 8.45e-23 Motion sickness; CRC cis rs9486719 1.000 rs4262195 chr6:96929475 T/C cg06623918 chr6:96969491 KIAA0776 -0.79 -9.15 -0.45 6.31e-18 Migraine;Coronary artery disease; CRC trans rs7615952 0.512 rs2979336 chr3:125357470 G/A cg21747405 chr11:67723411 NA -0.58 -8.99 -0.44 2e-17 Blood pressure (smoking interaction); CRC cis rs1519814 1.000 rs4271006 chr8:121146640 T/G cg22335954 chr8:121166405 COL14A1 -0.56 -6.44 -0.33 4.13e-10 Breast cancer; CRC cis rs6121246 0.559 rs6060962 chr20:30397847 A/G cg13852791 chr20:30311386 BCL2L1 0.8 15.91 0.66 1.15e-42 Mean corpuscular hemoglobin; CRC cis rs2019137 0.560 rs10206269 chr2:113990393 C/A cg21550016 chr2:113992930 PAX8;LOC440839;LOC654433 0.64 9.61 0.47 2.01e-19 Lymphocyte counts; CRC cis rs6866344 0.697 rs56159071 chr5:178127246 T/A cg03877680 chr5:178157825 ZNF354A 0.77 10.96 0.52 4.9299999999999996e-24 Neutrophil percentage of white cells; CRC cis rs8031584 0.958 rs7176569 chr15:31244495 G/T cg14829155 chr15:31115871 NA 0.48 7.78 0.39 9.35e-14 Huntington's disease progression; CRC cis rs17767392 0.670 rs17767386 chr14:71748353 T/C cg13720639 chr14:72061746 SIPA1L1 -0.44 -5.66 -0.3 3.27e-8 Mitral valve prolapse; CRC cis rs4780401 0.728 rs7188511 chr16:11773743 G/T cg01061890 chr16:11836724 TXNDC11 -0.47 -6.77 -0.35 5.92e-11 Rheumatoid arthritis; CRC cis rs9322193 0.884 rs2064521 chr6:149946472 A/C cg07701084 chr6:150067640 NUP43 -0.54 -7.88 -0.4 4.91e-14 Lung cancer; CRC cis rs2276314 0.748 rs4799839 chr18:33597531 T/C cg05985134 chr18:33552581 C18orf21 0.49 6.43 0.33 4.52e-10 Endometriosis;Drug-induced torsades de pointes; CRC cis rs473651 0.837 rs563458 chr2:239345613 T/A cg18131467 chr2:239335373 ASB1 1.03 23.4 0.79 5.63e-72 Multiple system atrophy; CRC cis rs1448094 0.717 rs60713909 chr12:86294469 C/G cg02569458 chr12:86230093 RASSF9 0.38 6.3 0.33 9.56e-10 Major depressive disorder; CRC cis rs10504229 0.861 rs114700910 chr8:58170642 C/T cg24829409 chr8:58192753 C8orf71 -0.68 -11.23 -0.53 5.45e-25 Developmental language disorder (linguistic errors); CRC cis rs17376456 0.877 rs12716456 chr5:93397557 A/G cg21475434 chr5:93447410 FAM172A 0.72 7.85 0.4 6.07e-14 Diabetic retinopathy; CRC trans rs2303319 0.504 rs56152608 chr2:162283469 G/A cg21546874 chr1:9294571 H6PD -0.76 -6.01 -0.31 4.89e-9 Cognitive function; CRC cis rs853679 0.882 rs4713139 chr6:28092685 C/T cg03623178 chr6:28175578 NA 0.83 6.72 0.35 7.91e-11 Depression; CRC cis rs394563 0.726 rs6922130 chr6:149672375 C/G cg16235748 chr6:149772707 ZC3H12D 0.38 6.97 0.36 1.78e-11 Dupuytren's disease; CRC cis rs10504229 0.595 rs116490935 chr8:58117531 A/G cg02290350 chr8:58132656 NA -0.57 -7.91 -0.4 4.05e-14 Developmental language disorder (linguistic errors); CRC trans rs2303319 0.504 rs55821334 chr2:162452014 A/G cg27113153 chr11:123612418 ZNF202 -0.7 -6.15 -0.32 2.28e-9 Cognitive function; CRC cis rs3204270 0.759 rs8071492 chr17:79682650 G/A cg09655341 chr17:79618100 PDE6G 0.5 5.83 0.31 1.35e-8 Dental caries; CRC trans rs2797160 1.000 rs1418951 chr6:125996185 A/G cg05039488 chr6:79577232 IRAK1BP1 -0.5 -7.61 -0.39 2.94e-13 Endometrial cancer; CRC cis rs10504229 0.683 rs56058640 chr8:58128862 C/T cg22535103 chr8:58192502 C8orf71 -0.7 -9.34 -0.46 1.47e-18 Developmental language disorder (linguistic errors); CRC cis rs6570726 0.516 rs9376932 chr6:145729490 T/C cg23711669 chr6:146136114 FBXO30 0.45 7.25 0.37 2.94e-12 Lobe attachment (rater-scored or self-reported); CRC cis rs2477686 0.526 rs1998759 chr1:2397174 C/T cg07700843 chr1:2391317 NA -0.46 -7.46 -0.38 7.97e-13 Non-obstructive azoospermia; CRC cis rs12479064 0.724 rs11885942 chr2:100004165 A/G cg14399236 chr2:99771627 LIPT1;TSGA10 -0.6 -7.22 -0.37 3.66e-12 Chronic sinus infection; CRC cis rs523522 0.923 rs1048830 chr12:120882217 G/T cg12219531 chr12:120966889 COQ5 0.64 8.43 0.42 1.11e-15 High light scatter reticulocyte count; CRC cis rs6921919 0.525 rs6929825 chr6:28378959 A/G cg21251018 chr6:28226885 NKAPL 0.39 5.93 0.31 7.61e-9 Autism spectrum disorder or schizophrenia; CRC cis rs13096480 0.583 rs17598137 chr3:49891362 G/T cg05142140 chr3:49055321 DALRD3 0.42 6.16 0.32 2.18e-9 Intelligence (multi-trait analysis); CRC cis rs2290159 0.800 rs60953453 chr3:12654921 C/A cg23032965 chr3:12705835 RAF1 0.47 6.31 0.33 8.78e-10 Cholesterol, total; CRC cis rs35883536 0.513 rs4907910 chr1:101013277 T/A cg06223162 chr1:101003688 GPR88 0.42 7.83 0.4 6.9e-14 Monocyte count; CRC cis rs6089584 0.850 rs6142938 chr20:60627723 A/C cg13770153 chr20:60521292 NA -0.6 -9.16 -0.45 5.57e-18 Body mass index; CRC cis rs2070488 0.662 rs7375040 chr3:38469116 A/G cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.57 8.49 0.42 7.26e-16 Electrocardiographic conduction measures; CRC cis rs933688 1.000 rs10041402 chr5:90738948 A/T cg26981201 chr5:90679533 LOC100129716;ARRDC3 1.0 16.26 0.67 4.86e-44 Smoking behavior; CRC cis rs11098699 0.821 rs6835952 chr4:124230974 A/C cg09941581 chr4:124220074 SPATA5 0.4 5.86 0.31 1.15e-8 Mosquito bite size; CRC cis rs875971 0.545 rs67775320 chr7:65658779 T/C cg02869306 chr7:64672164 INTS4L1 -0.42 -6.19 -0.32 1.74e-9 Aortic root size; CRC cis rs9527 0.567 rs6584539 chr10:104879402 G/C cg04362960 chr10:104952993 NT5C2 0.6 8.31 0.42 2.6e-15 Arsenic metabolism; CRC cis rs875971 0.545 rs75577046 chr7:65958716 A/G cg11764359 chr7:65958608 NA 0.45 5.62 0.3 4.01e-8 Aortic root size; CRC cis rs6565180 1.000 rs8049108 chr16:30376486 A/G cg17640201 chr16:30407289 ZNF48 -0.75 -13.14 -0.59 5.6199999999999995e-32 Tonsillectomy; CRC cis rs7932354 0.502 rs10769244 chr11:47182368 A/G cg19486271 chr11:47235900 DDB2 0.47 6.73 0.35 7.35e-11 Bone mineral density (hip);Bone mineral density; CRC cis rs1862618 0.671 rs2591955 chr5:56244948 C/T cg24531977 chr5:56204891 C5orf35 0.66 10.27 0.49 1.24e-21 Initial pursuit acceleration; CRC cis rs9916302 0.904 rs4794813 chr17:37670994 A/T cg00129232 chr17:37814104 STARD3 -0.55 -8.08 -0.41 1.24e-14 Glomerular filtration rate (creatinine); CRC cis rs9467711 0.538 rs35942482 chr6:26444938 T/A cg14345882 chr6:26364793 BTN3A2 0.7 5.67 0.3 3.1e-8 Autism spectrum disorder or schizophrenia; CRC cis rs17270561 0.609 rs1408271 chr6:25859621 T/A cg16482183 chr6:26056742 HIST1H1C 0.66 8.86 0.44 5.13e-17 Iron status biomarkers; CRC cis rs1552172 0.853 rs11591191 chr1:145675931 T/C cg11743829 chr1:145714124 CD160 -0.41 -6.18 -0.32 1.91e-9 Breast cancer; CRC cis rs3772130 1.000 rs33988592 chr3:121415610 G/A cg20356878 chr3:121714668 ILDR1 0.51 7.75 0.39 1.19e-13 Cognitive performance; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg18342900 chr16:46865048 C16orf87 0.5 7.39 0.38 1.19e-12 Response to antipsychotic treatment; CRC cis rs10504229 0.593 rs79874994 chr8:57993709 C/A cg08219700 chr8:58056026 NA 0.54 6.15 0.32 2.27e-9 Developmental language disorder (linguistic errors); CRC cis rs2857078 0.627 rs1476512 chr17:42330122 C/T cg13607699 chr17:42295918 UBTF -0.54 -8.1 -0.41 1.05e-14 Red cell distribution width;Reticulocyte count; CRC cis rs853679 1.000 rs1778508 chr6:28229881 C/T cg06470822 chr6:28175283 NA -0.6 -6.3 -0.33 9.67e-10 Depression; CRC cis rs1448094 1.000 rs1448094 chr12:86343135 G/T cg18827107 chr12:86230957 RASSF9 -0.37 -6.13 -0.32 2.49e-9 Major depressive disorder; CRC trans rs629535 0.748 rs689410 chr8:70037558 G/A cg21567404 chr3:27674614 NA 0.95 16.08 0.66 2.35e-43 Dupuytren's disease; CRC cis rs9837602 0.507 rs6803204 chr3:99680874 G/A cg07805332 chr3:99536008 MIR548G;C3orf26 0.51 7.66 0.39 2.03e-13 Breast cancer; CRC cis rs59104589 0.583 rs12618809 chr2:242249122 G/A cg19488206 chr2:242435732 STK25 0.48 6.72 0.35 7.88e-11 Fibrinogen levels; CRC cis rs1538970 0.781 rs34768551 chr1:46020408 G/A cg05343316 chr1:45956843 TESK2 0.74 9.61 0.47 1.93e-19 Platelet count; CRC cis rs9443645 0.901 rs1354832 chr6:79613763 A/G cg09184832 chr6:79620586 NA 0.51 9.44 0.46 7.33e-19 Intelligence (multi-trait analysis); CRC cis rs8180040 0.654 rs1466740 chr3:47245883 C/T cg10298567 chr3:47292165 KIF9 0.4 6.26 0.33 1.19e-9 Colorectal cancer; CRC cis rs4819052 1.000 rs13047688 chr21:46669290 G/A cg02159808 chr21:46707872 POFUT2;LOC642852 0.59 7.26 0.37 2.9e-12 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs743757 0.938 rs2236959 chr3:50441627 T/C cg09545109 chr3:50388910 TUSC4;CYB561D2 0.44 6.42 0.33 4.73e-10 Diastolic blood pressure; CRC trans rs2243480 0.908 rs55876148 chr7:65379800 G/A cg10756647 chr7:56101905 PSPH 0.69 7.34 0.38 1.66e-12 Diabetic kidney disease; CRC trans rs11148252 0.904 rs9526927 chr13:53051627 C/T cg18335740 chr13:41363409 SLC25A15 0.61 9.69 0.47 1.1e-19 Lewy body disease; CRC cis rs7586879 0.639 rs2033653 chr2:25103446 C/T cg04586622 chr2:25135609 ADCY3 0.54 9.91 0.48 1.99e-20 Body mass index; CRC cis rs6502050 0.871 rs6416857 chr17:80063004 A/G cg25804541 chr17:80189381 SLC16A3 0.32 6.01 0.31 4.85e-9 Life satisfaction; CRC cis rs6500602 0.647 rs1659497 chr16:4594635 G/A cg14951292 chr16:4525986 HMOX2;NMRAL1 -0.55 -8.46 -0.42 8.7e-16 Schizophrenia; CRC cis rs4731207 0.596 rs7791399 chr7:124577972 G/A cg23710748 chr7:124431027 NA -0.39 -6.12 -0.32 2.67e-9 Cutaneous malignant melanoma; CRC cis rs6662572 0.737 rs1355641 chr1:46599143 T/A cg03123370 chr1:45965343 CCDC163P;MMACHC 0.49 6.24 0.33 1.32e-9 Blood protein levels; CRC cis rs12893668 0.608 rs12889721 chr14:104034863 C/T cg08213375 chr14:104286397 PPP1R13B 0.37 5.99 0.31 5.42e-9 Reticulocyte count; CRC cis rs35110281 0.517 rs11089020 chr21:44939991 C/T cg01579765 chr21:45077557 HSF2BP -0.34 -6.14 -0.32 2.34e-9 Mean corpuscular volume; CRC cis rs514406 0.929 rs1672909 chr1:53340824 A/G cg27535305 chr1:53392650 SCP2 -0.36 -6.63 -0.34 1.37e-10 Monocyte count; CRC cis rs28830936 1.000 rs12440747 chr15:42036690 G/A cg17847044 chr15:42102381 MAPKBP1 -0.29 -6.35 -0.33 7.18e-10 Diastolic blood pressure; CRC cis rs6502050 0.835 rs55679819 chr17:80105450 C/T cg09264619 chr17:80180166 NA -0.34 -5.64 -0.3 3.61e-8 Life satisfaction; CRC cis rs4665809 0.549 rs72809635 chr2:26411674 G/A cg04944784 chr2:26401820 FAM59B 0.89 10.52 0.5 1.62e-22 Gut microbiome composition (summer); CRC cis rs1552244 0.572 rs17032426 chr3:10167112 G/A cg18598329 chr3:10140678 FANCD2;C3orf24 -0.91 -10.81 -0.51 1.62e-23 Alzheimer's disease; CRC trans rs7395662 0.534 rs12418219 chr11:48988091 G/T cg21153622 chr11:89784906 NA -0.53 -8.82 -0.44 6.69e-17 HDL cholesterol; CRC cis rs758324 0.947 rs6861732 chr5:131156462 A/C cg06307176 chr5:131281290 NA 0.42 6.18 0.32 1.92e-9 Alzheimer's disease in APOE e4- carriers; CRC cis rs62229266 0.659 rs2835242 chr21:37413532 A/C cg08632701 chr21:37451849 NA -0.41 -6.39 -0.33 5.8e-10 Mitral valve prolapse; CRC cis rs2839186 0.632 rs2839184 chr21:47689013 G/A cg00612595 chr21:47717864 NA -0.39 -6.19 -0.32 1.76e-9 Testicular germ cell tumor; CRC cis rs9462846 1.000 rs9462846 chr6:42861581 A/C cg21280719 chr6:42927975 GNMT -0.33 -5.86 -0.31 1.11e-8 Blood protein levels; CRC cis rs7412746 0.658 rs12068264 chr1:150727329 C/T cg10589385 chr1:150898437 SETDB1 0.32 6.51 0.34 2.73e-10 Melanoma; CRC cis rs2019137 0.936 rs12620738 chr2:113963739 C/T cg21550016 chr2:113992930 PAX8;LOC440839;LOC654433 -0.52 -7.47 -0.38 7.46e-13 Lymphocyte counts; CRC cis rs7927592 0.913 rs7116994 chr11:68254627 C/T cg16797656 chr11:68205561 LRP5 0.38 6.2 0.32 1.65e-9 Total body bone mineral density; CRC cis rs1950500 0.509 rs12882558 chr14:24819233 G/A cg16194253 chr14:24768981 DHRS1;C14orf21 0.4 5.78 0.3 1.71e-8 Height; CRC cis rs35110281 0.807 rs2838325 chr21:45014284 A/T cg04455712 chr21:45112962 RRP1B -0.38 -7.46 -0.38 7.61e-13 Mean corpuscular volume; CRC cis rs7932354 0.528 rs7946709 chr11:47100796 G/T cg19486271 chr11:47235900 DDB2 -0.49 -7.56 -0.38 4.17e-13 Bone mineral density (hip);Bone mineral density; CRC trans rs7395662 0.963 rs4882137 chr11:48615671 A/T cg21153622 chr11:89784906 NA -0.45 -7.22 -0.37 3.57e-12 HDL cholesterol; CRC cis rs10751667 0.666 rs7395488 chr11:954111 T/C ch.11.42038R chr11:967971 AP2A2 0.57 9.75 0.47 6.98e-20 Alzheimer's disease (late onset); CRC cis rs1003719 0.715 rs2156077 chr21:38539357 C/T cg10648535 chr21:38446584 PIGP;TTC3 -0.48 -6.72 -0.35 7.91e-11 Eye color traits; CRC cis rs8077889 0.917 rs72836553 chr17:41909851 A/G cg26893861 chr17:41843967 DUSP3 0.96 12.36 0.56 4.54e-29 Triglycerides; CRC cis rs9549328 0.700 rs34890317 chr13:113617245 G/C cg08614441 chr13:113633676 MCF2L 0.4 7.08 0.36 8.63e-12 Systolic blood pressure; CRC cis rs76993477 0.666 rs12142587 chr1:169716214 G/A cg03211132 chr1:169703751 SELE 0.61 5.83 0.31 1.32e-8 Tonsillectomy; CRC cis rs116095464 0.558 rs55776650 chr5:273826 G/A cg22857025 chr5:266934 NA -1.24 -16.67 -0.68 1.18e-45 Breast cancer; CRC cis rs4964805 0.865 rs11111796 chr12:104205928 C/T cg02344784 chr12:104178138 NT5DC3 0.47 6.78 0.35 5.56e-11 Attention deficit hyperactivity disorder; CRC cis rs4819052 0.851 rs10470245 chr21:46658912 A/G cg19498844 chr21:46707878 POFUT2;LOC642852 0.77 10.99 0.52 3.85e-24 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs611744 0.608 rs667742 chr8:109254003 T/C cg21045802 chr8:109455806 TTC35 0.42 6.68 0.35 1.05e-10 Dupuytren's disease; CRC cis rs989128 0.642 rs8077323 chr17:48626398 C/T cg24438145 chr17:48624694 SPATA20 0.52 7.41 0.38 1.04e-12 Type 2 diabetes; CRC cis rs16975963 0.843 rs3848624 chr19:38262816 C/T cg15135657 chr19:38346511 NA -0.45 -5.92 -0.31 7.95e-9 Longevity; CRC cis rs3749237 0.576 rs4241406 chr3:49600426 C/T cg02487422 chr3:49467188 NICN1 0.43 7.04 0.36 1.15e-11 Resting heart rate; CRC cis rs838147 0.505 rs1688264 chr19:49209560 T/G cg21064579 chr19:49206444 FUT2 0.5 8.73 0.43 1.3e-16 Dietary macronutrient intake; CRC cis rs6570726 0.516 rs10457779 chr6:145736663 C/T cg23711669 chr6:146136114 FBXO30 0.45 7.24 0.37 3.18e-12 Lobe attachment (rater-scored or self-reported); CRC cis rs4588572 0.644 rs10942856 chr5:77746199 A/G cg11446398 chr5:77624930 NA -0.4 -5.92 -0.31 8.19e-9 Triglycerides; CRC cis rs9322193 0.962 rs11155685 chr6:150102785 A/C cg13206674 chr6:150067644 NUP43 0.57 8.14 0.41 8.29e-15 Lung cancer; CRC cis rs11190604 1.000 rs10883506 chr10:102289743 C/G cg16342193 chr10:102329863 NA -0.36 -5.94 -0.31 7.21e-9 Palmitoleic acid (16:1n-7) levels; CRC cis rs12476592 0.602 rs7563623 chr2:63720210 A/G cg10828910 chr2:63850056 LOC388955 0.49 6.08 0.32 3.33e-9 Childhood ear infection; CRC cis rs2153535 0.580 rs9505446 chr6:8448691 T/C cg21535247 chr6:8435926 SLC35B3 0.5 7.5 0.38 6.06e-13 Motion sickness; CRC cis rs208520 0.661 rs704519 chr6:66801136 T/C cg07460842 chr6:66804631 NA -1.07 -15.1 -0.64 1.63e-39 Exhaled nitric oxide output; CRC cis rs4824093 0.535 rs73441802 chr22:50273916 G/A cg22709217 chr22:50311962 ALG12;CRELD2 -0.98 -8.74 -0.43 1.26e-16 Amyotrophic lateral sclerosis (sporadic); CRC cis rs1348850 1.000 rs1348850 chr2:178418575 A/G cg22681709 chr2:178499509 PDE11A -0.37 -6.9 -0.36 2.66e-11 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs7715806 0.500 rs17649248 chr5:74998426 C/T cg00601450 chr5:74908170 NA 0.48 5.91 0.31 8.64e-9 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs2795502 0.564 rs11239840 chr10:43439353 C/T cg20628663 chr10:43360327 NA 0.57 6.85 0.35 3.55e-11 Blood protein levels; CRC cis rs3789045 0.528 rs61817953 chr1:204462612 G/A cg17419461 chr1:204415978 PIK3C2B -0.57 -7.78 -0.39 9.73e-14 Educational attainment (college completion); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg02076939 chr11:118042561 SCN2B 0.42 6.0 0.31 5.31e-9 Response to antipsychotic treatment; CRC cis rs2439831 0.681 rs3742971 chr15:43622916 A/G cg15269541 chr15:43626905 ADAL 0.46 6.13 0.32 2.56e-9 Lung cancer in ever smokers; CRC cis rs12048904 0.541 rs1571046 chr1:101299216 T/C cg15686842 chr1:101360669 SLC30A7;EXTL2 0.55 7.31 0.37 2.05e-12 Multiple sclerosis; CRC cis rs1218582 0.772 rs4240875 chr1:154885782 G/A cg09359103 chr1:154839909 KCNN3 -0.7 -12.43 -0.57 2.31e-29 Prostate cancer; CRC cis rs7786808 0.649 rs6459879 chr7:158211792 C/G cg09998033 chr7:158218633 PTPRN2 -0.46 -6.54 -0.34 2.41e-10 Obesity-related traits; CRC cis rs6831352 0.734 rs2602856 chr4:100029145 C/A cg13256891 chr4:100009986 ADH5 0.55 7.83 0.4 6.61e-14 Alcohol dependence; CRC cis rs9487051 0.676 rs1521905 chr6:109594515 T/C cg21918786 chr6:109611834 NA -0.42 -7.46 -0.38 7.91e-13 Reticulocyte fraction of red cells; CRC cis rs1577917 0.629 rs9450285 chr6:86208096 A/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A 0.49 6.9 0.36 2.61e-11 Response to antipsychotic treatment; CRC cis rs28386778 0.897 rs7222189 chr17:61836372 T/C cg07362569 chr17:61921086 SMARCD2 0.37 5.76 0.3 1.89e-8 Prudent dietary pattern; CRC cis rs2204008 0.774 rs11520273 chr12:38354075 A/T cg13010199 chr12:38710504 ALG10B 0.47 6.43 0.33 4.6e-10 Bladder cancer; CRC cis rs875971 0.862 rs778707 chr7:65857027 G/A cg18876405 chr7:65276391 NA 0.54 8.69 0.43 1.77e-16 Aortic root size; CRC cis rs6951245 1.000 rs74366004 chr7:1088630 A/C cg24642844 chr7:1081250 C7orf50 -0.79 -9.35 -0.46 1.4e-18 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs9549328 0.670 rs61963562 chr13:113616523 T/G cg24588162 chr13:113633484 MCF2L 0.36 6.43 0.33 4.47e-10 Systolic blood pressure; CRC cis rs6860806 0.507 rs270601 chr5:131656997 T/C cg18758796 chr5:131593413 PDLIM4 0.4 6.46 0.34 3.74e-10 Breast cancer; CRC cis rs11676348 0.935 rs4674250 chr2:218977531 G/A cg04731861 chr2:219085781 ARPC2 0.28 5.97 0.31 6.18e-9 Ulcerative colitis; CRC cis rs910316 1.000 rs28626045 chr14:75589195 G/C cg03030879 chr14:75389066 RPS6KL1 -0.46 -7.38 -0.38 1.34e-12 Height; CRC cis rs6088590 1.000 rs28542147 chr20:33376323 G/A cg08999081 chr20:33150536 PIGU 0.51 8.48 0.42 7.61e-16 Coronary artery disease; CRC cis rs17711722 0.727 rs781151 chr7:65479878 T/C cg18876405 chr7:65276391 NA 0.67 11.75 0.54 7.17e-27 Calcium levels; CRC cis rs7131987 0.834 rs7139273 chr12:29434650 T/C cg09582351 chr12:29534625 ERGIC2 -0.29 -6.28 -0.33 1.1e-9 QT interval; CRC cis rs10504229 0.595 rs76447299 chr8:58117395 A/G cg04204079 chr8:58130323 NA -0.45 -5.78 -0.3 1.71e-8 Developmental language disorder (linguistic errors); CRC cis rs4253772 0.637 rs9627402 chr22:46702586 C/T cg09491104 chr22:46646882 C22orf40 -0.41 -5.66 -0.3 3.33e-8 LDL cholesterol;Cholesterol, total; CRC cis rs853679 0.517 rs9295761 chr6:28147987 A/G cg15845792 chr6:28175446 NA 1.04 13.9 0.61 6.84e-35 Depression; CRC cis rs13191362 1.000 rs35818596 chr6:163001874 C/G cg06582575 chr6:163149167 PACRG;PARK2 0.77 10.7 0.51 3.98e-23 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs13108904 0.870 rs13132584 chr4:1251504 G/T cg16405210 chr4:1374714 KIAA1530 -0.43 -6.1 -0.32 2.91e-9 Obesity-related traits; CRC cis rs832540 0.669 rs832539 chr5:56199386 A/C cg20203395 chr5:56204925 C5orf35 -0.54 -7.44 -0.38 9.1e-13 Coronary artery disease; CRC cis rs7923609 0.936 rs10822160 chr10:65112796 T/G cg08743896 chr10:65200160 JMJD1C -0.4 -5.69 -0.3 2.88e-8 Educational attainment;Liver enzyme levels (alkaline phosphatase); CRC cis rs992157 1.000 rs6736362 chr2:219115108 C/T cg04731861 chr2:219085781 ARPC2 -0.29 -6.05 -0.32 3.84e-9 Colorectal cancer; CRC cis rs9733 0.596 rs11803569 chr1:150664077 C/T cg18016565 chr1:150552671 MCL1 0.46 6.74 0.35 6.91e-11 Tonsillectomy; CRC trans rs7726839 0.540 rs3762951 chr5:662613 C/G cg25482853 chr8:67687455 SGK3 1.12 13.08 0.58 8.83e-32 Obesity-related traits; CRC trans rs35110281 0.667 rs4819285 chr21:45118970 C/T cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO -0.41 -6.69 -0.35 9.38e-11 Mean corpuscular volume; CRC cis rs6951245 1.000 rs11761941 chr7:1097183 G/A cg22907277 chr7:1156413 C7orf50 0.73 7.68 0.39 1.78e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs3857536 0.813 rs1891600 chr6:66941645 G/C cg07460842 chr6:66804631 NA -0.43 -5.81 -0.3 1.48e-8 Blood trace element (Cu levels); CRC cis rs9341808 0.628 rs1892475 chr6:80862213 T/C cg08355045 chr6:80787529 NA 0.34 5.89 0.31 9.39e-9 Sitting height ratio; CRC cis rs4713118 0.513 rs149958 chr6:28013617 A/C cg15845792 chr6:28175446 NA 0.77 11.37 0.53 1.74e-25 Parkinson's disease; CRC cis rs1023500 0.505 rs134887 chr22:42674239 A/G cg15557168 chr22:42548783 NA -0.36 -6.2 -0.32 1.7e-9 Schizophrenia; CRC cis rs6502050 0.835 rs3935403 chr17:80114145 C/T cg25804541 chr17:80189381 SLC16A3 -0.3 -5.92 -0.31 8.17e-9 Life satisfaction; CRC cis rs8177253 0.665 rs8177178 chr3:133463272 G/A cg08048268 chr3:133502702 NA -0.32 -5.62 -0.3 3.99e-8 Iron status biomarkers; CRC cis rs4150161 0.591 rs3785036 chr16:84219810 T/G cg10106505 chr16:84220380 TAF1C -1.17 -9.98 -0.48 1.17e-20 Systolic blood pressure response to hydrochlorothiazide in hypertension; CRC cis rs10782582 0.593 rs2147039 chr1:76143166 C/T cg03433033 chr1:76189801 ACADM -0.43 -6.25 -0.33 1.3e-9 Daytime sleep phenotypes; CRC cis rs4889855 0.530 rs12946972 chr17:78618922 A/G cg16591659 chr17:78472290 NA -0.43 -6.23 -0.32 1.43e-9 Fractional excretion of uric acid; CRC cis rs2836974 0.831 rs34592564 chr21:40516288 G/C cg11644478 chr21:40555479 PSMG1 0.71 10.09 0.49 4.9e-21 Cognitive function; CRC trans rs35110281 0.712 rs162345 chr21:44954155 T/G cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.43 6.88 0.35 3.12e-11 Mean corpuscular volume; CRC cis rs651907 0.557 rs13066768 chr3:101486920 A/T cg12386194 chr3:101231763 SENP7 -0.49 -7.24 -0.37 3.29e-12 Colorectal cancer; CRC cis rs1691799 0.899 rs1168295 chr12:66734151 G/C cg16791601 chr12:66731901 HELB -0.67 -11.29 -0.53 3.38e-25 White blood cell count (basophil); CRC cis rs10861342 1.000 rs10861360 chr12:105570041 A/G cg23923672 chr12:105501055 KIAA1033 -0.59 -5.62 -0.3 4.09e-8 IgG glycosylation; CRC cis rs9611565 0.918 rs9611566 chr22:41768625 A/G cg06634786 chr22:41940651 POLR3H 0.64 7.83 0.4 6.74e-14 Vitiligo; CRC trans rs1814175 0.817 rs1818890 chr11:49856882 T/C cg21153622 chr11:89784906 NA -0.38 -6.2 -0.32 1.74e-9 Height; CRC cis rs2071303 0.836 rs198835 chr6:26113994 T/G cg18357526 chr6:26021779 HIST1H4A -0.48 -7.22 -0.37 3.66e-12 Intelligence (multi-trait analysis); CRC trans rs7726839 0.507 rs60068988 chr5:597668 T/C cg25482853 chr8:67687455 SGK3 1.09 12.84 0.58 7.36e-31 Obesity-related traits; CRC cis rs7539542 0.556 rs4950889 chr1:202874786 T/C cg19681188 chr1:202830198 LOC148709 0.46 6.67 0.35 1.09e-10 Mean platelet volume; CRC cis rs514406 0.793 rs12402415 chr1:53218539 G/T cg25767906 chr1:53392781 SCP2 0.39 6.32 0.33 8.54e-10 Monocyte count; CRC cis rs7192750 0.583 rs8046916 chr16:72047751 C/G cg14768367 chr16:72042858 DHODH -0.76 -6.69 -0.35 9.69e-11 LDL cholesterol levels;Total cholesterol levels; CRC cis rs524281 0.861 rs10896091 chr11:65950825 T/C cg14036092 chr11:66035641 RAB1B -0.47 -5.71 -0.3 2.54e-8 Electroencephalogram traits; CRC cis rs1129187 0.935 rs9986447 chr6:42942779 C/T cg02359409 chr6:42947317 PEX6 0.58 8.88 0.44 4.33e-17 Alzheimer's disease in APOE e4+ carriers; CRC cis rs10504229 0.679 rs72649114 chr8:58037491 G/T cg22535103 chr8:58192502 C8orf71 -0.44 -5.8 -0.3 1.58e-8 Developmental language disorder (linguistic errors); CRC cis rs10493773 0.962 rs6698578 chr1:86236676 G/A cg17807903 chr1:86174739 ZNHIT6 -0.49 -9.68 -0.47 1.12e-19 Urate levels in overweight individuals; CRC trans rs7819412 0.749 rs11991118 chr8:10939273 A/C cg06636001 chr8:8085503 FLJ10661 0.51 7.99 0.4 2.3e-14 Triglycerides; CRC cis rs6426558 0.537 rs6682642 chr1:227244600 G/T cg10327440 chr1:227177885 CDC42BPA 0.44 6.69 0.35 9.83e-11 Neutrophil percentage of white cells; CRC cis rs62229266 0.804 rs2835259 chr21:37425302 T/C cg08632701 chr21:37451849 NA -0.45 -7.15 -0.37 5.77e-12 Mitral valve prolapse; CRC cis rs9300255 0.602 rs949142 chr12:123634043 T/C cg00376283 chr12:123451042 ABCB9 0.61 8.42 0.42 1.18e-15 Neutrophil percentage of white cells; CRC cis rs12476592 0.602 rs2604613 chr2:63832776 G/A cg10828910 chr2:63850056 LOC388955 0.5 6.13 0.32 2.54e-9 Childhood ear infection; CRC trans rs7937682 0.924 rs12791699 chr11:111505880 T/C cg18187862 chr3:45730750 SACM1L 0.48 6.88 0.35 3.04e-11 Primary sclerosing cholangitis; CRC cis rs17253792 0.822 rs28409547 chr14:56047826 C/T cg01858014 chr14:56050164 KTN1 -0.92 -8.25 -0.41 3.95e-15 Putamen volume; CRC cis rs1552244 1.000 rs66797209 chr3:10078526 G/A cg18598329 chr3:10140678 FANCD2;C3orf24 -0.89 -11.87 -0.55 2.69e-27 Alzheimer's disease; CRC trans rs12635820 0.504 rs79853094 chr3:80385001 G/A cg23627948 chr7:2760692 NA 0.41 6.11 0.32 2.74e-9 Glomerular filtration rate in chronic kidney disease; CRC cis rs4253772 0.515 rs9615968 chr22:46772695 A/G cg24881330 chr22:46731750 TRMU 0.67 5.71 0.3 2.56e-8 LDL cholesterol;Cholesterol, total; CRC cis rs1519814 0.956 rs4369033 chr8:121138921 C/A cg22335954 chr8:121166405 COL14A1 -0.56 -6.44 -0.33 4.13e-10 Breast cancer; CRC cis rs3617 0.573 rs2336667 chr3:52916363 C/T cg15147215 chr3:52552868 STAB1 0.43 7.18 0.37 4.63e-12 Red blood cell count;Autism spectrum disorder or schizophrenia; CRC cis rs6960043 0.875 rs17168594 chr7:15048776 T/C cg19272540 chr7:15055459 NA -0.22 -5.82 -0.31 1.39e-8 Type 2 diabetes; CRC cis rs9914988 0.943 rs34693224 chr17:27079555 C/T cg07195577 chr17:27052828 TLCD1 0.41 5.9 0.31 9.27e-9 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg24028381 chr8:145133668 EXOSC4 -0.42 -6.28 -0.33 1.04e-9 Myopia (pathological); CRC cis rs1552244 0.554 rs58020561 chr3:10054682 A/G cg02579736 chr3:10068473 FANCD2;CIDECP 0.69 9.67 0.47 1.28e-19 Alzheimer's disease; CRC cis rs7258465 0.897 rs1043327 chr19:18554972 A/G cg06462663 chr19:18546047 ISYNA1 0.47 7.08 0.36 8.57e-12 Breast cancer; CRC cis rs4731207 0.698 rs7793258 chr7:124448012 G/A cg23710748 chr7:124431027 NA 0.37 5.96 0.31 6.53e-9 Cutaneous malignant melanoma; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg19845159 chr8:146012669 ZNF34 0.44 6.14 0.32 2.44e-9 Anxiety disorder; CRC cis rs796364 0.806 rs203765 chr2:200903020 G/A cg12253985 chr2:200820533 C2orf60;C2orf47 -0.57 -5.62 -0.3 4.18e-8 Schizophrenia; CRC cis rs9488822 0.636 rs7745074 chr6:116347432 G/A cg26893134 chr6:116381904 FRK 0.27 7.79 0.39 8.83e-14 Cholesterol, total;LDL cholesterol; CRC cis rs970548 0.697 rs11239534 chr10:45968590 A/T cg15590007 chr10:45870220 ALOX5 -0.55 -5.64 -0.3 3.76e-8 Total cholesterol levels;Cholesterol, total;HDL cholesterol;HDL cholesterol levels; CRC cis rs919433 0.680 rs7590010 chr2:198400668 C/T cg10820045 chr2:198174542 NA 0.41 6.81 0.35 4.64e-11 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC cis rs6840360 1.000 rs6823194 chr4:152604543 T/C cg09659197 chr4:152720779 NA 0.49 10.37 0.5 5.37e-22 Intelligence (multi-trait analysis); CRC cis rs11971779 0.774 rs6467838 chr7:139043501 A/G cg23387468 chr7:139079360 LUC7L2 0.41 7.04 0.36 1.14e-11 Diisocyanate-induced asthma; CRC cis rs17401966 0.800 rs2039778 chr1:10354601 A/G cg19773385 chr1:10388646 KIF1B -0.67 -11.0 -0.52 3.44e-24 Hepatocellular carcinoma; CRC cis rs17666538 0.710 rs7834337 chr8:655828 A/G cg13264159 chr8:625131 ERICH1 -0.63 -6.4 -0.33 5.5e-10 IgG glycosylation; CRC cis rs7589728 1.000 rs75181745 chr2:88520408 C/T cg04511125 chr2:88470314 THNSL2 0.73 7.5 0.38 5.96e-13 Plasma clusterin levels; CRC cis rs977987 0.806 rs766521 chr16:75424154 A/G cg03315344 chr16:75512273 CHST6 -0.55 -9.21 -0.45 3.79e-18 Dupuytren's disease; CRC cis rs950169 0.840 rs62029595 chr15:84955301 C/T cg17507749 chr15:85114479 UBE2QP1 0.73 10.52 0.5 1.65e-22 Schizophrenia; CRC cis rs2836974 0.644 rs2836982 chr21:40689171 C/A cg11644478 chr21:40555479 PSMG1 -0.62 -9.5 -0.46 4.66e-19 Cognitive function; CRC cis rs6120849 0.754 rs17319032 chr20:33643296 T/C cg08999081 chr20:33150536 PIGU 0.44 5.72 0.3 2.39e-8 Protein C levels; CRC trans rs3942852 0.726 rs1503171 chr11:48175152 T/C cg03929089 chr4:120376271 NA -0.72 -9.05 -0.45 1.27e-17 Acute lymphoblastic leukemia (childhood); CRC cis rs10504229 0.683 rs882429 chr8:58129292 A/G cg24829409 chr8:58192753 C8orf71 -0.55 -8.03 -0.4 1.71e-14 Developmental language disorder (linguistic errors); CRC cis rs965469 1.000 rs6037562 chr20:3326141 A/C cg25506879 chr20:3388711 C20orf194 -0.37 -5.6 -0.3 4.41e-8 IFN-related cytopenia; CRC cis rs514406 0.729 rs534070 chr1:53308858 T/G cg27535305 chr1:53392650 SCP2 -0.43 -7.76 -0.39 1.07e-13 Monocyte count; CRC cis rs72615157 0.634 rs7789890 chr7:99800559 G/T cg19337854 chr7:99768885 GPC2 0.48 6.42 0.33 4.73e-10 Lung function (FEV1/FVC); CRC cis rs11690935 0.877 rs13024846 chr2:172835803 C/T cg13550731 chr2:172543902 DYNC1I2 -1.07 -17.35 -0.69 2.4e-48 Schizophrenia; CRC cis rs1862618 0.671 rs2034244 chr5:56242774 T/C cg18230493 chr5:56204884 C5orf35 0.59 8.77 0.44 1.01e-16 Initial pursuit acceleration; CRC trans rs2921036 0.529 rs2979192 chr8:8338147 C/T cg16141378 chr3:129829833 LOC729375 -0.52 -7.59 -0.39 3.29e-13 Neuroticism; CRC cis rs7615952 0.688 rs12485622 chr3:125710739 T/C cg18479299 chr3:125709523 NA -0.52 -6.36 -0.33 6.72e-10 Blood pressure (smoking interaction); CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg02664216 chr12:19592651 AEBP2 -0.61 -7.63 -0.39 2.63e-13 Diisocyanate-induced asthma; CRC cis rs28386778 0.933 rs2665804 chr17:61951836 G/T cg06601766 chr17:61851465 DDX42;CCDC47 0.46 6.35 0.33 7.21e-10 Prudent dietary pattern; CRC cis rs4604732 0.631 rs12039642 chr1:247624898 A/G cg12758973 chr1:247694275 LOC148824;OR2C3 0.42 6.14 0.32 2.32e-9 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CRC cis rs9393692 0.905 rs7746807 chr6:26293338 C/A cg13736514 chr6:26305472 NA -0.62 -11.53 -0.54 4.55e-26 Educational attainment; CRC cis rs929354 0.557 rs62491947 chr7:156960813 G/A cg17757837 chr7:157058334 UBE3C 0.74 12.44 0.57 2.23e-29 Body mass index; CRC cis rs2180341 0.855 rs9385422 chr6:127716457 C/T cg24812749 chr6:127587940 RNF146 0.67 9.2 0.45 4.12e-18 Breast cancer; CRC cis rs10504229 0.906 rs56138544 chr8:58184558 A/C cg01721255 chr8:58191610 C8orf71 0.49 6.17 0.32 2e-9 Developmental language disorder (linguistic errors); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg00234608 chr9:139702971 C9orf86;LOC100131193 0.4 6.52 0.34 2.57e-10 Liver disease severity in Alagille syndrome; CRC cis rs7201929 1.000 rs8061877 chr16:28856819 C/T cg10436792 chr16:28889110 ATP2A1 0.41 5.64 0.3 3.61e-8 QT interval; CRC cis rs910316 0.673 rs2012627 chr14:75443103 C/T cg11812906 chr14:75593930 NEK9 0.54 8.19 0.41 5.95e-15 Height; CRC cis rs769267 0.930 rs10414830 chr19:19562332 C/T cg03709012 chr19:19516395 GATAD2A 0.73 11.48 0.53 6.77e-26 Tonsillectomy; CRC cis rs1127311 1.000 rs1127313 chr1:154556425 A/G cg17218026 chr1:154582156 ADAR -0.54 -9.21 -0.45 3.9e-18 C-reactive protein levels or triglyceride levels (pleiotropy); CRC cis rs6545883 0.862 rs1880866 chr2:61698972 G/C cg15711740 chr2:61764176 XPO1 -0.43 -5.68 -0.3 2.9e-8 Tuberculosis; CRC cis rs17767392 0.958 rs34957192 chr14:71752336 G/A cg13720639 chr14:72061746 SIPA1L1 -0.51 -6.49 -0.34 3.22e-10 Mitral valve prolapse; CRC cis rs13315871 1.000 rs9824965 chr3:58433505 T/A cg20936604 chr3:58311152 NA -0.72 -7.15 -0.37 5.58e-12 Cholesterol, total; CRC trans rs1908814 0.516 rs58869268 chr8:11797095 G/C cg06636001 chr8:8085503 FLJ10661 0.48 7.08 0.36 8.64e-12 Neuroticism; CRC cis rs59574136 1 rs59574136 chr7:2036460 T/C cg18279126 chr7:2041391 MAD1L1 0.39 5.78 0.3 1.76e-8 Autism spectrum disorder or schizophrenia; CRC cis rs4604732 0.631 rs12031694 chr1:247623653 C/T cg02104434 chr1:247694406 LOC148824;OR2C3 0.58 8.42 0.42 1.14e-15 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CRC cis rs1218582 0.688 rs58629129 chr1:154910930 T/C cg03351412 chr1:154909251 PMVK 0.51 7.22 0.37 3.73e-12 Prostate cancer; CRC cis rs11190604 1.000 rs12219158 chr10:102302923 T/C cg16342193 chr10:102329863 NA -0.36 -5.95 -0.31 6.71e-9 Palmitoleic acid (16:1n-7) levels; CRC cis rs6496667 0.865 rs7171617 chr15:90904858 G/A cg04176472 chr15:90893244 GABARAPL3 0.51 7.67 0.39 1.91e-13 Rheumatoid arthritis; CRC trans rs2727020 0.658 rs1851992 chr11:49438110 C/T cg03929089 chr4:120376271 NA -0.87 -16.07 -0.66 2.67e-43 Coronary artery disease; CRC trans rs877282 0.945 rs877280 chr10:771599 C/T cg22713356 chr15:30763199 NA 1.28 16.09 0.66 2.14e-43 Uric acid levels; CRC cis rs597539 0.652 rs10792001 chr11:68637737 G/C cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.89 15.85 0.66 1.89e-42 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs1005277 0.579 rs2505197 chr10:38393310 T/C cg25517755 chr10:38738941 LOC399744 -0.44 -6.41 -0.33 5.05e-10 Extrinsic epigenetic age acceleration; CRC cis rs2274273 0.840 rs6573020 chr14:55871452 C/T cg23234261 chr14:55582407 NA -0.28 -5.74 -0.3 2.15e-8 Protein biomarker; CRC cis rs6964587 0.692 rs10236483 chr7:91797296 A/C cg17063962 chr7:91808500 NA 0.62 10.1 0.49 4.48e-21 Breast cancer; CRC cis rs6570726 0.526 rs4895674 chr6:145735860 T/G cg23711669 chr6:146136114 FBXO30 -0.47 -7.37 -0.38 1.42e-12 Lobe attachment (rater-scored or self-reported); CRC cis rs62064224 0.589 rs9903650 chr17:30689370 T/A cg18200150 chr17:30822561 MYO1D 0.44 8.58 0.43 3.85e-16 Schizophrenia; CRC cis rs10927875 0.691 rs1048261 chr1:16340951 A/T cg21385522 chr1:16154831 NA 0.62 7.77 0.39 1.04e-13 Dilated cardiomyopathy; CRC cis rs1552244 0.872 rs115331527 chr3:10154504 G/A cg10729496 chr3:10149963 C3orf24 0.57 7.29 0.37 2.39e-12 Alzheimer's disease; CRC cis rs1387259 0.839 rs7487682 chr12:48579665 A/C cg15465823 chr12:48382534 COL2A1 -0.36 -5.9 -0.31 9.14e-9 Obstructive sleep apnea trait (apnea hypopnea index); CRC cis rs40363 0.645 rs6501177 chr16:3523681 C/T cg00484396 chr16:3507460 NAT15 0.55 8.2 0.41 5.47e-15 Tuberculosis; CRC cis rs965469 0.779 rs6515810 chr20:3370861 T/C cg25506879 chr20:3388711 C20orf194 -0.37 -5.76 -0.3 1.96e-8 IFN-related cytopenia; CRC cis rs7580658 0.929 rs11886231 chr2:128028130 G/A cg09760422 chr2:128146352 NA -0.37 -7.27 -0.37 2.72e-12 Protein C levels; CRC cis rs904251 0.772 rs2252920 chr6:37418327 A/G cg01843034 chr6:37503916 NA -0.35 -5.66 -0.3 3.3e-8 Cognitive performance; CRC cis rs9916302 0.706 rs649180 chr17:37464959 A/C cg07936489 chr17:37558343 FBXL20 0.85 9.91 0.48 2.03e-20 Glomerular filtration rate (creatinine); CRC cis rs6951245 1.000 rs77760339 chr7:1083927 G/T cg08132940 chr7:1081526 C7orf50 -0.54 -5.64 -0.3 3.65e-8 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs28386778 0.700 rs11079515 chr17:62005645 C/G cg06873352 chr17:61820015 STRADA -0.54 -8.98 -0.44 2.17e-17 Prudent dietary pattern; CRC cis rs3796619 1.000 rs12647929 chr4:1092019 G/T cg11579758 chr4:1086637 RNF212 0.41 6.74 0.35 7.01e-11 Recombination rate (males); CRC cis rs17152411 1.000 rs17152381 chr10:126592903 T/G cg07906193 chr10:126599966 NA 0.58 6.52 0.34 2.69e-10 Height; CRC cis rs12681288 0.823 rs2701903 chr8:1004029 A/G cg04851639 chr8:1020857 NA 0.28 6.09 0.32 3.19e-9 Schizophrenia; CRC cis rs77861329 0.748 rs893055 chr3:52177348 T/C cg08692210 chr3:52188851 WDR51A 0.51 5.92 0.31 7.96e-9 Macrophage inflammatory protein 1b levels; CRC cis rs8180040 0.726 rs4682837 chr3:46999707 C/T cg27129171 chr3:47204927 SETD2 0.65 10.49 0.5 2.1e-22 Colorectal cancer; CRC cis rs2204008 0.527 rs1315367 chr12:38177487 G/T cg26384229 chr12:38710491 ALG10B -0.56 -8.25 -0.41 3.97e-15 Bladder cancer; CRC cis rs4319547 0.695 rs10773167 chr12:122934001 C/T cg23029597 chr12:123009494 RSRC2 -0.57 -6.96 -0.36 1.89e-11 Body mass index; CRC cis rs9660180 0.837 rs915292 chr1:1792157 A/C cg05132306 chr1:1846340 CALML6 -0.51 -7.92 -0.4 3.77e-14 Body mass index; CRC cis rs9322193 0.962 rs1112730 chr6:150087519 G/A cg05861140 chr6:150128134 PCMT1 -0.44 -7.18 -0.37 4.53e-12 Lung cancer; CRC cis rs780096 0.506 rs1262430 chr2:27673798 T/C cg27432699 chr2:27873401 GPN1 -0.51 -7.75 -0.39 1.14e-13 Total body bone mineral density; CRC trans rs1814175 0.715 rs1722007 chr11:49897319 T/C cg11707556 chr5:10655725 ANKRD33B -0.43 -8.12 -0.41 9.35e-15 Height; CRC cis rs2086824 0.538 rs4785673 chr16:89536545 A/G cg00750074 chr16:89608354 SPG7 -0.45 -6.67 -0.35 1.05e-10 Multiple myeloma (IgH translocation); CRC cis rs1572438 0.811 rs6916781 chr6:880493 G/A cg21062780 chr6:887772 NA 0.41 6.67 0.35 1.09e-10 Aging; CRC cis rs644799 1.000 rs580255 chr11:95577929 T/C cg25622487 chr11:95524042 FAM76B;CEP57 0.77 12.02 0.55 7.58e-28 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs7503807 0.515 rs12450876 chr17:78682630 A/G cg00549398 chr17:78725201 RPTOR 0.43 5.77 0.3 1.86e-8 Obesity; CRC cis rs798766 1.000 rs4865463 chr4:1742400 T/C cg05874882 chr4:1763078 NA -0.38 -7.12 -0.37 6.66e-12 Bladder cancer;Urinary bladder cancer; CRC cis rs62577244 0.645 rs111342974 chr9:138434448 G/A cg14582108 chr9:138439003 OBP2A 0.53 8.19 0.41 5.83e-15 Subcutaneous adipose tissue (sex interaction);Subcutaneous adipose tissue; CRC cis rs10751667 0.643 rs10902234 chr11:935578 A/G cg01483505 chr11:975446 AP2A2 0.44 7.24 0.37 3.16e-12 Alzheimer's disease (late onset); CRC cis rs2228479 0.850 rs62054599 chr16:89808850 C/G cg19635926 chr16:89946313 TCF25 0.66 5.98 0.31 5.71e-9 Skin colour saturation; CRC cis rs78456975 0.941 rs11886649 chr2:1567757 A/G cg26248373 chr2:1572462 NA -0.71 -8.13 -0.41 8.56e-15 Placebo response in major depressive disorder (% change in symptom score); CRC cis rs9322193 0.923 rs9479094 chr6:150046219 C/T cg07701084 chr6:150067640 NUP43 0.56 8.32 0.42 2.38e-15 Lung cancer; CRC cis rs4727027 0.933 rs6464940 chr7:148826309 G/T cg12479418 chr7:148823350 ZNF425;ZNF398 0.41 5.61 0.3 4.31e-8 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC cis rs12497850 0.931 rs9840050 chr3:49133310 A/G cg07636037 chr3:49044803 WDR6 1.01 17.0 0.68 5.91e-47 Parkinson's disease; CRC cis rs2239547 0.522 rs2581779 chr3:53056199 T/C cg18404041 chr3:52824283 ITIH1 0.35 6.38 0.33 6.17e-10 Schizophrenia; CRC cis rs4713675 0.565 rs4711343 chr6:33714548 G/A cg14003231 chr6:33640908 ITPR3 0.45 7.43 0.38 9.44e-13 Plateletcrit; CRC cis rs1552244 0.882 rs56224841 chr3:10044014 A/C cg02579736 chr3:10068473 FANCD2;CIDECP 0.93 12.04 0.55 6.69e-28 Alzheimer's disease; CRC cis rs4665809 1.000 rs4665816 chr2:26305094 G/C cg22920501 chr2:26401640 FAM59B -0.5 -6.95 -0.36 1.99e-11 Gut microbiome composition (summer); CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg19238398 chr5:138775248 DNAJC18 -0.39 -6.04 -0.32 4.22e-9 Myopia (pathological); CRC cis rs2380220 0.810 rs66524640 chr6:95956566 T/C cg04719120 chr6:96025338 MANEA -0.55 -6.04 -0.32 4.15e-9 Behavioural disinhibition (generation interaction); CRC cis rs68170813 0.559 rs77422419 chr7:106957932 A/G cg02696742 chr7:106810147 HBP1 -0.59 -6.54 -0.34 2.29e-10 Coronary artery disease; CRC cis rs11971779 0.680 rs1133067 chr7:139053069 G/T cg07862535 chr7:139043722 LUC7L2 0.57 7.35 0.38 1.61e-12 Diisocyanate-induced asthma; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg23194596 chr7:36193344 EEPD1 0.36 6.03 0.32 4.5e-9 Liver disease severity in Alagille syndrome; CRC cis rs877282 1.000 rs71491304 chr10:772982 C/T cg06581033 chr10:766294 NA -0.47 -5.71 -0.3 2.58e-8 Uric acid levels; CRC cis rs4862750 0.874 rs6822062 chr4:187895553 T/C cg03452623 chr4:187889614 NA -0.93 -21.97 -0.77 1.75e-66 Lobe attachment (rater-scored or self-reported); CRC trans rs1814175 0.935 rs11040438 chr11:49622521 G/A cg03929089 chr4:120376271 NA -0.94 -17.32 -0.69 3.26e-48 Height; CRC cis rs7044106 0.762 rs7357638 chr9:123389204 G/A cg09419670 chr9:123605666 PSMD5;LOC253039 0.69 10.64 0.51 6.51e-23 Hip circumference adjusted for BMI; CRC cis rs17384381 0.859 rs35761966 chr1:85918357 G/A cg16011679 chr1:85725395 C1orf52 0.56 5.98 0.31 5.78e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs9322193 0.884 rs9383864 chr6:150173105 T/C cg05861140 chr6:150128134 PCMT1 -0.43 -6.99 -0.36 1.55e-11 Lung cancer; CRC cis rs2439831 0.867 rs935901 chr15:43651256 G/C cg15269541 chr15:43626905 ADAL -0.58 -6.1 -0.32 2.92e-9 Lung cancer in ever smokers; CRC cis rs6502050 0.799 rs7502533 chr17:80109778 A/G cg02741985 chr17:80059408 CCDC57 0.43 7.15 0.37 5.66e-12 Life satisfaction; CRC cis rs2625529 0.526 rs8040828 chr15:72492779 C/A cg16672083 chr15:72433130 SENP8 0.43 6.47 0.34 3.51e-10 Red blood cell count; CRC cis rs7713065 0.531 rs2522051 chr5:131797578 C/T cg12564285 chr5:131593104 PDLIM4 0.36 6.67 0.35 1.1e-10 Lung function (FEV1/FVC); CRC cis rs796364 1.000 rs166845 chr2:200823360 T/A cg23649088 chr2:200775458 C2orf69 0.53 5.75 0.3 2.03e-8 Schizophrenia; CRC cis rs73200209 0.744 rs2392968 chr12:116533861 A/C cg01776926 chr12:116560359 MED13L -0.63 -7.65 -0.39 2.3e-13 Total body bone mineral density; CRC trans rs9858542 0.953 rs7633271 chr3:49555963 T/C cg21582582 chr3:182698605 DCUN1D1 -0.52 -6.57 -0.34 1.95e-10 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs7258465 0.965 rs10409003 chr19:18543054 C/T cg10790698 chr19:18539756 SSBP4 -0.47 -8.71 -0.43 1.53e-16 Breast cancer; CRC cis rs11098499 0.754 rs1980026 chr4:120251643 C/A cg24375607 chr4:120327624 NA 0.47 7.6 0.39 3.06e-13 Corneal astigmatism; CRC cis rs9747201 1.000 rs62078307 chr17:80090053 G/T cg14673194 chr17:80132900 CCDC57 0.48 6.23 0.32 1.41e-9 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs11098499 0.863 rs2306456 chr4:120472422 C/G cg09307838 chr4:120376055 NA 0.68 10.13 0.49 3.65e-21 Corneal astigmatism; CRC cis rs4713118 0.513 rs149972 chr6:27983227 C/T cg20615401 chr6:28092323 ZSCAN16 0.47 6.36 0.33 6.89e-10 Parkinson's disease; CRC cis rs6089584 0.927 rs2296083 chr20:60574216 C/T cg06108461 chr20:60628389 TAF4 -0.69 -11.98 -0.55 1.08e-27 Body mass index; CRC cis rs9325144 0.647 rs11169258 chr12:39113040 C/T cg26384229 chr12:38710491 ALG10B -0.51 -7.12 -0.37 6.71e-12 Morning vs. evening chronotype; CRC cis rs6912958 0.703 rs12207825 chr6:88098292 C/T cg12350822 chr6:88032061 C6orf162;GJB7 0.47 9.32 0.46 1.78e-18 Monocyte percentage of white cells; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg23585910 chr11:134123368 THYN1;ACAD8 0.48 7.05 0.36 1.08e-11 Intelligence (multi-trait analysis); CRC cis rs9427116 1.000 rs9427117 chr1:154632231 C/G cg17218026 chr1:154582156 ADAR 0.42 6.49 0.34 3.12e-10 Blood protein levels; CRC cis rs10256972 0.552 rs6978842 chr7:1204599 A/C cg03923535 chr7:1197113 ZFAND2A 0.69 10.34 0.5 7.18e-22 Longevity;Endometriosis; CRC trans rs12599106 0.754 rs11640596 chr16:34347277 T/C cg26668828 chr6:292823 DUSP22 -0.59 -8.55 -0.43 4.8e-16 Menopause (age at onset); CRC cis rs720844 1.000 rs1031290 chr2:149367295 T/C cg09247360 chr2:149335327 NA -0.53 -6.78 -0.35 5.62e-11 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs916888 0.773 rs538628 chr17:44787313 G/C cg15921436 chr17:44337874 NA 0.8 8.33 0.42 2.23e-15 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs10927875 0.965 rs3961710 chr1:16313172 C/T cg22431228 chr1:16359049 CLCNKA 0.35 5.92 0.31 7.99e-9 Dilated cardiomyopathy; CRC cis rs9649213 0.593 rs6465666 chr7:97937258 C/T cg00277769 chr7:97922759 BAIAP2L1 0.61 10.67 0.51 4.89e-23 Prostate cancer (SNP x SNP interaction); CRC cis rs2180341 1.000 rs4897207 chr6:127605898 C/T cg27446573 chr6:127587934 RNF146 0.99 14.76 0.63 3.48e-38 Breast cancer; CRC trans rs2303319 0.504 rs62189043 chr2:162608466 A/T cg20024234 chr21:43431083 ZNF295 -0.66 -5.99 -0.31 5.57e-9 Cognitive function; CRC cis rs798766 1.000 rs2166580 chr4:1743169 G/A cg05874882 chr4:1763078 NA -0.39 -7.16 -0.37 5.26e-12 Bladder cancer;Urinary bladder cancer; CRC cis rs9487051 1.000 rs9386796 chr6:109618704 C/T cg01475377 chr6:109611718 NA -0.45 -7.98 -0.4 2.4e-14 Reticulocyte fraction of red cells; CRC trans rs4942242 0.512 rs9533551 chr13:44187120 G/C cg19169023 chr15:41853346 TYRO3 -0.64 -8.73 -0.43 1.32e-16 Response to tocilizumab in rheumatoid arthritis; CRC cis rs4819052 0.851 rs28616694 chr21:46674786 G/C cg19498844 chr21:46707878 POFUT2;LOC642852 0.78 11.18 0.52 8.32e-25 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs870825 0.616 rs7683799 chr4:185632164 T/C cg04058563 chr4:185651563 MLF1IP 0.74 9.5 0.46 4.52e-19 Blood protein levels; CRC cis rs6502050 0.799 rs4789667 chr17:80162143 C/T cg25804541 chr17:80189381 SLC16A3 -0.3 -5.82 -0.31 1.41e-8 Life satisfaction; CRC cis rs951366 0.646 rs1772159 chr1:205759195 G/A cg11965913 chr1:205819406 PM20D1 0.98 16.93 0.68 1.13e-46 Menarche (age at onset); CRC cis rs4481887 0.927 rs4381224 chr1:248456826 A/T cg00666640 chr1:248458726 OR2T12 0.54 9.57 0.47 2.69e-19 Common traits (Other); CRC cis rs690037 0.673 rs690573 chr3:16376440 G/T cg23474789 chr3:16306055 DPH3;OXNAD1 -0.43 -5.87 -0.31 1.05e-8 Optic nerve measurement (cup-to-disc ratio);Optic nerve measurement (cup area); CRC cis rs10752881 0.967 rs4652757 chr1:182974750 T/A ch.1.3577855R chr1:183094577 LAMC1 0.87 15.17 0.64 8.98e-40 Colorectal cancer; CRC cis rs12410462 0.681 rs115959512 chr1:227599578 T/C cg04117972 chr1:227635322 NA 0.76 6.59 0.34 1.73e-10 Major depressive disorder; CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg11050527 chr8:54755511 ATP6V1H -0.52 -6.26 -0.33 1.18e-9 Diisocyanate-induced asthma; CRC cis rs2070997 0.702 rs3780284 chr9:133733961 A/G cg01000188 chr9:133769184 QRFP 0.48 6.01 0.31 5e-9 Response to amphetamines; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg02523617 chr4:39699380 UBE2K 0.46 7.0 0.36 1.41e-11 Liver disease severity in Alagille syndrome; CRC cis rs7584330 0.554 rs880931 chr2:238396741 G/A cg08992911 chr2:238395768 MLPH 0.62 6.12 0.32 2.71e-9 Prostate cancer; CRC trans rs1973993 0.689 rs17375929 chr1:96962246 A/T cg10631902 chr5:14652156 NA -0.4 -6.72 -0.35 7.89e-11 Weight; CRC cis rs3126085 0.515 rs1923506 chr1:152359700 A/T cg09127314 chr1:152161683 NA -0.44 -5.86 -0.31 1.13e-8 Atopic dermatitis; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg13425637 chr14:61788328 PRKCH 0.44 7.25 0.37 2.99e-12 Liver disease severity in Alagille syndrome; CRC cis rs12134245 0.776 rs12137878 chr1:91973210 G/T cg02896835 chr1:92012615 NA -0.63 -11.11 -0.52 1.41e-24 Breast cancer; CRC cis rs6662572 0.737 rs56316933 chr1:46266725 C/T cg08644498 chr1:46502608 NA 0.44 6.64 0.34 1.28e-10 Blood protein levels; CRC cis rs9837602 1.000 rs1688766 chr3:99647850 G/A cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G 0.47 5.68 0.3 3.03e-8 Breast cancer; CRC cis rs7119 0.717 rs62007350 chr15:77804590 G/A cg10437265 chr15:77819839 NA 0.67 11.9 0.55 2.1e-27 Type 2 diabetes; CRC trans rs8035957 1.000 rs4924273 chr15:38846738 C/G cg05972000 chr8:67525501 MYBL1 -0.48 -5.96 -0.31 6.52e-9 Type 1 diabetes; CRC trans rs3018066 0.518 rs12648091 chr4:107291528 G/C cg07070047 chr13:25497298 CENPJ -0.62 -5.96 -0.31 6.39e-9 Cancer; CRC cis rs66782572 1 rs66782572 chr3:52567617 A/G cg13284614 chr3:52569169 NT5DC2;LOC440957 0.38 6.22 0.32 1.53e-9 Hemoglobin concentration; CRC cis rs7666738 0.830 rs9992639 chr4:98940400 G/T cg05340658 chr4:99064831 C4orf37 0.6 9.35 0.46 1.41e-18 Colonoscopy-negative controls vs population controls; CRC cis rs3806843 0.900 rs2531341 chr5:140130894 C/T cg16607685 chr5:140181889 PCDHA2;PCDHA1;PCDHA3 0.26 5.93 0.31 7.73e-9 Depressive symptoms (multi-trait analysis); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg05175466 chr13:52586483 ALG11;ATP7B 0.46 6.55 0.34 2.23e-10 Response to antipsychotic treatment; CRC trans rs10028773 0.600 rs4001390 chr4:120265783 G/C cg25214090 chr10:38739885 LOC399744 0.53 8.51 0.42 6.36e-16 Educational attainment; CRC cis rs2070488 0.931 rs7630012 chr3:38552250 A/G cg01465620 chr3:38496096 LOC100128640;ACVR2B -0.89 -16.64 -0.68 1.57e-45 Electrocardiographic conduction measures; CRC cis rs9916302 0.904 rs585961 chr17:37444036 G/A cg00129232 chr17:37814104 STARD3 0.54 8.05 0.41 1.49e-14 Glomerular filtration rate (creatinine); CRC cis rs7402982 0.525 rs11247361 chr15:99207392 C/G cg03437748 chr15:99193247 IGF1R -0.46 -6.05 -0.32 3.97e-9 Birth weight; CRC cis rs514406 0.861 rs7526275 chr1:53245849 C/T cg25767906 chr1:53392781 SCP2 0.45 7.22 0.37 3.55e-12 Monocyte count; CRC cis rs1707322 0.721 rs10890336 chr1:46111056 C/T cg06784218 chr1:46089804 CCDC17 0.66 12.52 0.57 1.07e-29 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs9911578 1.000 rs391370 chr17:56675050 A/C cg05425664 chr17:57184151 TRIM37 -0.5 -7.98 -0.4 2.49e-14 Intelligence (multi-trait analysis); CRC cis rs10504229 0.683 rs11774585 chr8:58132685 G/A cg24829409 chr8:58192753 C8orf71 -0.55 -8.03 -0.4 1.71e-14 Developmental language disorder (linguistic errors); CRC cis rs2303745 0.589 rs1864116 chr19:17393015 C/T cg04248312 chr19:17393744 ANKLE1 -0.93 -14.35 -0.62 1.31e-36 Systemic lupus erythematosus; CRC cis rs7605827 0.930 rs9287661 chr2:15595901 G/A cg19274914 chr2:15703543 NA 0.39 6.03 0.32 4.51e-9 Educational attainment (years of education); CRC cis rs9527 0.615 rs11191401 chr10:104573403 A/G cg04362960 chr10:104952993 NT5C2 0.64 7.85 0.4 5.9e-14 Arsenic metabolism; CRC cis rs4664308 0.691 rs1877196 chr2:160915150 G/T cg03641300 chr2:160917029 PLA2R1 -0.69 -11.16 -0.52 1.01e-24 Idiopathic membranous nephropathy; CRC cis rs8072100 0.840 rs9893901 chr17:45506682 T/G cg25173405 chr17:45401733 C17orf57 -0.48 -7.58 -0.39 3.52e-13 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs9549328 0.614 rs34306822 chr13:113616499 G/A cg17524180 chr13:113633600 MCF2L 0.52 9.39 0.46 1e-18 Systolic blood pressure; CRC cis rs10927875 0.800 rs1627145 chr1:16328116 C/T cg10494257 chr1:16342123 HSPB7 0.44 5.95 0.31 7.02e-9 Dilated cardiomyopathy; CRC cis rs17270561 0.609 rs9358887 chr6:25759406 G/T cg17691542 chr6:26056736 HIST1H1C 0.68 8.51 0.42 6.14e-16 Iron status biomarkers; CRC cis rs9926296 0.568 rs1230 chr16:89804855 A/G cg03388025 chr16:89894329 SPIRE2 -0.42 -8.25 -0.41 3.81e-15 Vitiligo; CRC cis rs7312933 0.558 rs11181422 chr12:42718552 G/A cg11827402 chr12:42719852 PPHLN1;ZCRB1 -0.63 -9.23 -0.45 3.51e-18 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CRC cis rs2535633 0.631 rs9823697 chr3:53002150 A/G cg11645453 chr3:52864694 ITIH4 0.4 7.43 0.38 9.36e-13 Body mass index; CRC cis rs9660992 0.674 rs1151784 chr1:205232447 C/T cg21643547 chr1:205240462 TMCC2 -0.46 -7.24 -0.37 3.14e-12 Mean corpuscular volume;Mean platelet volume; CRC cis rs1395 1.000 rs4665958 chr2:27443196 A/G cg23587288 chr2:27483067 SLC30A3 -0.32 -5.64 -0.3 3.58e-8 Blood metabolite levels; CRC cis rs11608355 0.515 rs61941592 chr12:109930497 G/A cg05360138 chr12:110035743 NA 0.72 8.21 0.41 5.14e-15 Neuroticism; CRC cis rs6500602 0.701 rs4786508 chr16:4568043 G/A cg14951292 chr16:4525986 HMOX2;NMRAL1 0.72 9.98 0.48 1.16e-20 Schizophrenia; CRC cis rs6570726 0.875 rs1883407 chr6:145823432 T/C cg05347473 chr6:146136440 FBXO30 0.39 6.06 0.32 3.69e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs747650 0.504 rs34340483 chr11:46953154 T/G cg19486271 chr11:47235900 DDB2 -0.44 -6.69 -0.35 9.4e-11 Acne (severe); CRC cis rs447 1.000 rs10263314 chr7:83776972 C/T cg22846510 chr7:83753280 SEMA3A -0.55 -6.81 -0.35 4.68e-11 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs12325245 0.536 rs35432891 chr16:58561966 G/A cg26666090 chr16:58549219 SETD6 0.9 6.11 0.32 2.86e-9 Schizophrenia; CRC cis rs5758511 0.680 rs5758681 chr22:42645091 A/G cg00645731 chr22:42541494 CYP2D7P1 0.65 10.06 0.48 6.34e-21 Birth weight; CRC cis rs56114371 0.777 rs200481 chr6:27773832 A/T cg26587870 chr6:27730563 NA -0.63 -6.65 -0.34 1.19e-10 Breast cancer; CRC trans rs1814175 0.791 rs10839395 chr11:49846274 G/T cg21153622 chr11:89784906 NA -0.39 -6.25 -0.33 1.24e-9 Height; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg05720666 chr2:69969591 ANXA4 0.46 6.68 0.35 1.01e-10 Response to antipsychotic treatment; CRC cis rs10540 1.000 rs12786555 chr11:506229 C/T cg21784768 chr11:537496 LRRC56 -0.69 -6.56 -0.34 2.11e-10 Body mass index; CRC cis rs7772486 0.641 rs960385 chr6:146371074 G/A cg05347473 chr6:146136440 FBXO30 0.49 7.12 0.37 7e-12 Lobe attachment (rater-scored or self-reported); CRC cis rs7615952 0.673 rs16834637 chr3:125605471 C/T cg05084668 chr3:125655381 ALG1L -0.7 -8.89 -0.44 4.01e-17 Blood pressure (smoking interaction); CRC cis rs873946 0.517 rs7071784 chr10:134559980 T/C cg26818010 chr10:134567672 INPP5A -0.52 -7.25 -0.37 2.98e-12 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CRC cis rs2153535 0.601 rs1855768 chr6:8472969 T/G cg21535247 chr6:8435926 SLC35B3 0.5 7.53 0.38 4.89e-13 Motion sickness; CRC cis rs977987 0.835 rs4888379 chr16:75340231 A/T cg03315344 chr16:75512273 CHST6 0.52 8.86 0.44 5.26e-17 Dupuytren's disease; CRC cis rs7705042 0.865 rs413214 chr5:141530157 G/A cg08523384 chr5:141488047 NDFIP1 -0.32 -5.71 -0.3 2.48e-8 Asthma; CRC cis rs4713118 0.955 rs9468204 chr6:27688809 C/T cg20933634 chr6:27740509 NA 0.57 8.07 0.41 1.38e-14 Parkinson's disease; CRC cis rs2251381 0.606 rs8129515 chr21:30520167 C/G cg08807101 chr21:30365312 RNF160 0.62 8.89 0.44 4.01e-17 Selective IgA deficiency; CRC trans rs9291683 0.546 rs13120348 chr4:10053155 C/G cg26043149 chr18:55253948 FECH -0.53 -8.0 -0.4 2.12e-14 Bone mineral density; CRC cis rs7474896 0.537 rs2749586 chr10:38270214 G/C cg25427524 chr10:38739819 LOC399744 0.59 7.32 0.37 1.94e-12 Obesity (extreme); CRC cis rs7918232 0.882 rs6415983 chr10:27357211 A/G cg14442939 chr10:27389572 ANKRD26 0.8 8.74 0.43 1.23e-16 Breast cancer; CRC cis rs896854 0.738 rs509594 chr8:95967156 C/G cg13393036 chr8:95962371 TP53INP1 0.45 6.73 0.35 7.51e-11 Type 2 diabetes; CRC trans rs561341 0.769 rs12941700 chr17:30185022 A/G cg00801512 chr17:28996047 NA 0.56 6.68 0.35 1.04e-10 Hip circumference adjusted for BMI; CRC cis rs78456975 0.600 rs72776256 chr2:1529595 C/A cg12573674 chr2:1569213 NA -0.75 -7.58 -0.39 3.52e-13 Placebo response in major depressive disorder (% change in symptom score); CRC cis rs7692995 1.000 rs16896312 chr4:18030853 C/T cg08925142 chr4:18023851 LCORL -0.53 -5.86 -0.31 1.13e-8 Height; CRC cis rs736408 0.522 rs11130310 chr3:52674667 C/T cg05573699 chr3:52720067 GNL3;PBRM1 -0.47 -6.95 -0.36 1.93e-11 Bipolar disorder; CRC cis rs62064224 0.714 rs11657299 chr17:30634951 G/A cg18200150 chr17:30822561 MYO1D 0.47 9.56 0.47 2.81e-19 Schizophrenia; CRC cis rs10782582 0.586 rs5745383 chr1:76288590 G/C cg10523679 chr1:76189770 ACADM -0.4 -5.71 -0.3 2.56e-8 Daytime sleep phenotypes; CRC cis rs1580019 0.587 rs9638880 chr7:32552401 A/G cg14728415 chr7:32535168 LSM5;AVL9 0.45 6.36 0.33 6.86e-10 Cognitive ability; CRC cis rs3858526 0.883 rs7481882 chr11:5944221 A/G cg02574844 chr11:5959923 NA -0.42 -5.84 -0.31 1.23e-8 DNA methylation (variation); CRC trans rs57221529 0.766 rs56216231 chr5:581193 G/A cg11887960 chr12:57824829 NA 0.63 6.79 0.35 5.32e-11 Lung disease severity in cystic fibrosis; CRC cis rs9291683 0.588 rs35099040 chr4:10018839 T/C cg11266682 chr4:10021025 SLC2A9 0.54 11.43 0.53 1.09e-25 Bone mineral density; CRC cis rs11098499 0.820 rs2389885 chr4:120533931 C/T cg24375607 chr4:120327624 NA 0.55 7.93 0.4 3.5e-14 Corneal astigmatism; CRC cis rs11212617 1.000 rs2884030 chr11:108281903 C/T cg01991180 chr11:108092276 ATM;NPAT 0.43 6.51 0.34 2.74e-10 Response to metformin in type 2 diabetes (glycemic); CRC cis rs4901869 0.902 rs10149194 chr14:59308198 A/G cg02291164 chr14:59296302 NA -0.37 -6.93 -0.36 2.28e-11 Panic disorder; CRC cis rs6743376 0.532 rs2251872 chr2:113818632 G/A cg24553058 chr2:113831203 IL1F10 0.43 6.96 0.36 1.81e-11 Inflammatory biomarkers; CRC cis rs7666738 0.830 rs7691864 chr4:98971376 G/C cg17366294 chr4:99064904 C4orf37 0.44 7.32 0.37 1.94e-12 Colonoscopy-negative controls vs population controls; CRC cis rs6504622 0.537 rs1618989 chr17:44993708 T/C cg16759221 chr17:45003025 GOSR2 -0.71 -11.36 -0.53 1.91e-25 Orofacial clefts; CRC cis rs9527 0.615 rs11191485 chr10:104729816 G/C cg15744005 chr10:104629667 AS3MT -0.31 -6.17 -0.32 1.99e-9 Arsenic metabolism; CRC cis rs7707921 1.000 rs1019806 chr5:81551659 G/A cg17942617 chr5:81327376 ATG10 -0.39 -5.85 -0.31 1.2e-8 Breast cancer; CRC cis rs2836950 0.762 rs8134638 chr21:40644170 T/C cg17971929 chr21:40555470 PSMG1 -0.47 -6.09 -0.32 3.18e-9 Menarche (age at onset); CRC cis rs3858526 0.959 rs4559671 chr11:5923419 C/T cg13902645 chr11:5959945 NA -0.63 -8.78 -0.44 8.96e-17 DNA methylation (variation); CRC cis rs1881797 1.000 rs1881794 chr1:247682920 G/C cg11166453 chr1:247681781 NA -0.48 -8.71 -0.43 1.53e-16 Acute lymphoblastic leukemia (childhood); CRC cis rs1624802 0.638 rs1696431 chr12:130498408 C/T cg15444478 chr12:130494697 NA 0.31 6.13 0.32 2.53e-9 Obesity-related traits; CRC cis rs9399135 0.967 rs2183709 chr6:135377091 C/T cg24558204 chr6:135376177 HBS1L 0.49 7.57 0.39 3.72e-13 Red blood cell count; CRC trans rs2303319 0.504 rs1023835 chr2:162593973 A/G cg11326919 chr17:43324904 LOC100133991 -0.64 -5.97 -0.31 5.99e-9 Cognitive function; CRC trans rs2727020 0.658 rs7120136 chr11:49384358 A/C cg15704280 chr7:45808275 SEPT13 -0.92 -17.3 -0.69 3.99e-48 Coronary artery disease; CRC cis rs2075371 0.933 rs1833474 chr7:133958240 A/G cg11752832 chr7:134001865 SLC35B4 0.44 6.72 0.35 8.13e-11 Mean platelet volume; CRC cis rs9393692 0.905 rs1125000 chr6:26287256 C/T cg00631329 chr6:26305371 NA -0.69 -13.43 -0.6 4.41e-33 Educational attainment; CRC cis rs9287719 0.639 rs2357649 chr2:10696788 C/T cg00105475 chr2:10696890 NA -0.56 -9.37 -0.46 1.22e-18 Prostate cancer; CRC cis rs35146811 0.538 rs3823642 chr7:99796072 T/C cg00553149 chr7:99775558 STAG3;GPC2 0.24 5.89 0.31 9.67e-9 Coronary artery disease; CRC cis rs1799949 1.000 rs4793190 chr17:41200109 T/C cg25072359 chr17:41440525 NA 0.45 6.82 0.35 4.26e-11 Menopause (age at onset); CRC cis rs12477438 0.520 rs13004491 chr2:99738008 T/C cg14399236 chr2:99771627 LIPT1;TSGA10 0.82 14.43 0.62 6.73e-37 Chronic sinus infection; CRC cis rs1707322 0.721 rs11211181 chr1:46236800 C/T cg03146154 chr1:46216737 IPP 0.59 8.62 0.43 2.93e-16 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs2658782 0.951 rs2608214 chr11:93148665 C/T cg21115391 chr11:93143810 CCDC67 -0.38 -5.7 -0.3 2.74e-8 Pulmonary function decline; CRC trans rs2727020 0.595 rs7924311 chr11:49507573 G/A cg11707556 chr5:10655725 ANKRD33B -0.4 -7.47 -0.38 7.49e-13 Coronary artery disease; CRC cis rs1957429 0.808 rs4902327 chr14:65344803 C/T cg23373153 chr14:65346875 NA 0.91 7.98 0.4 2.38e-14 Pediatric areal bone mineral density (radius); CRC trans rs2303319 0.582 rs62187608 chr2:162431138 T/G cg09481857 chr22:21368659 P2RX6;MGC16703 -0.65 -6.12 -0.32 2.66e-9 Cognitive function; CRC trans rs7845127 0.535 rs7815626 chr8:18171218 C/T cg07676709 chr17:46673442 LOC404266;HOXB6 -0.41 -5.99 -0.31 5.44e-9 Night sleep phenotypes; CRC cis rs9487051 0.837 rs932223 chr6:109586656 A/G cg12927641 chr6:109611667 NA -0.36 -6.41 -0.33 5.18e-10 Reticulocyte fraction of red cells; CRC cis rs2354432 0.556 rs4424557 chr1:146871119 A/G cg25205988 chr1:146714368 CHD1L 1.11 9.62 0.47 1.8e-19 Mitochondrial DNA levels; CRC cis rs911119 0.955 rs67997662 chr20:23592864 G/A cg16589663 chr20:23618590 CST3 0.45 6.3 0.33 9.76e-10 Chronic kidney disease; CRC trans rs7267979 1.000 rs761025 chr20:25426968 G/A cg17903999 chr18:56338584 MALT1 -0.41 -6.71 -0.35 8.45e-11 Liver enzyme levels (alkaline phosphatase); CRC cis rs9649213 0.593 rs6465665 chr7:97934150 T/C cg08684580 chr7:98029266 BAIAP2L1 -0.31 -5.62 -0.3 4.07e-8 Prostate cancer (SNP x SNP interaction); CRC cis rs2153535 0.580 rs7743686 chr6:8526111 A/G cg21535247 chr6:8435926 SLC35B3 0.49 7.47 0.38 7.44e-13 Motion sickness; CRC cis rs72781680 0.898 rs72786276 chr2:24062566 G/A cg08917208 chr2:24149416 ATAD2B 1.06 10.05 0.48 6.48e-21 Lymphocyte counts; CRC cis rs1005277 0.579 rs2474575 chr10:38387901 C/T cg17219203 chr10:38645113 HSD17B7P2 -0.41 -5.76 -0.3 1.9e-8 Extrinsic epigenetic age acceleration; CRC cis rs12762955 0.507 rs7070724 chr10:1040138 C/T cg26597838 chr10:835615 NA -0.43 -5.75 -0.3 2e-8 Response to angiotensin II receptor blocker therapy; CRC cis rs9902453 0.845 rs7222842 chr17:28246943 C/T cg26525008 chr17:28256777 EFCAB5;SSH2 0.57 8.68 0.43 1.86e-16 Coffee consumption (cups per day); CRC trans rs2228479 0.850 rs62054601 chr16:89811751 C/G cg21302420 chr1:112162376 RAP1A 0.72 6.01 0.31 5.05e-9 Skin colour saturation; CRC cis rs12530845 0.623 rs73721669 chr7:135347107 C/G cg23117316 chr7:135346802 PL-5283 -0.51 -6.47 -0.34 3.65e-10 Red blood cell traits; CRC cis rs77972916 0.536 rs11679731 chr2:43589064 A/T cg06169590 chr2:43455088 ZFP36L2;LOC100129726 -0.53 -5.89 -0.31 9.78e-9 Granulocyte percentage of myeloid white cells; CRC cis rs10504229 0.728 rs17215753 chr8:58153764 A/G cg05313129 chr8:58192883 C8orf71 -0.47 -6.18 -0.32 1.94e-9 Developmental language disorder (linguistic errors); CRC cis rs4819052 0.679 rs28623526 chr21:46712324 T/C cg02159808 chr21:46707872 POFUT2;LOC642852 0.44 6.2 0.32 1.67e-9 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs13118159 0.550 rs1137789 chr4:1381798 A/G cg19318889 chr4:1322082 MAEA 0.67 9.84 0.48 3.29e-20 Longevity; CRC cis rs10256972 0.591 rs6950319 chr7:1161324 A/G cg23708337 chr7:1209742 NA 0.42 6.15 0.32 2.21e-9 Longevity;Endometriosis; CRC cis rs1552244 0.882 rs67895180 chr3:10026079 T/C cg16606324 chr3:10149918 C3orf24 0.61 7.98 0.4 2.47e-14 Alzheimer's disease; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg21954346 chr16:68271489 ESRP2 0.43 6.04 0.32 4.07e-9 Response to antipsychotic treatment; CRC cis rs801193 0.569 rs2013908 chr7:66121069 A/T cg00343986 chr7:65444356 GUSB -0.45 -6.2 -0.32 1.7e-9 Aortic root size; CRC cis rs7666738 0.791 rs1830231 chr4:99026185 A/C cg17366294 chr4:99064904 C4orf37 0.44 7.43 0.38 9.49e-13 Colonoscopy-negative controls vs population controls; CRC cis rs853679 0.517 rs9393896 chr6:28127703 C/T cg21251018 chr6:28226885 NKAPL 0.48 6.17 0.32 2.02e-9 Depression; CRC cis rs1499614 0.901 rs2178742 chr7:66197799 G/A cg12463550 chr7:65579703 CRCP 0.62 5.63 0.3 3.93e-8 Gout; CRC cis rs6502050 0.830 rs7219036 chr17:80161119 T/C cg02741985 chr17:80059408 CCDC57 0.42 7.04 0.36 1.16e-11 Life satisfaction; CRC cis rs9549367 0.673 rs575453 chr13:113837871 C/A cg00898013 chr13:113819073 PROZ 0.53 7.74 0.39 1.27e-13 Platelet distribution width; CRC cis rs1555322 0.505 rs591590 chr20:33866028 A/G cg03689076 chr20:33865952 NA -0.57 -7.66 -0.39 2.11e-13 Attention deficit hyperactivity disorder; CRC cis rs1008375 1.000 rs9991307 chr4:17662408 A/G cg15017067 chr4:17643749 FAM184B 0.36 5.73 0.3 2.24e-8 Parasitemia in Tripanosoma cruzi seropositivity; CRC trans rs2727020 0.664 rs4929893 chr11:49196332 C/T cg15704280 chr7:45808275 SEPT13 -0.82 -13.85 -0.61 1.11e-34 Coronary artery disease; CRC cis rs7208859 0.573 rs8078182 chr17:29149664 C/T cg19761014 chr17:28927070 LRRC37B2 0.52 6.13 0.32 2.48e-9 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs12541635 0.677 rs12546875 chr8:107012915 C/T cg10147462 chr8:107024639 NA 0.57 9.97 0.48 1.29e-20 Age of smoking initiation; CRC cis rs8058578 1.000 rs2289442 chr16:30739919 A/G cg02466173 chr16:30829666 NA -0.81 -12.7 -0.57 2.36e-30 Multiple myeloma; CRC trans rs1455244 0.700 rs7229302 chr18:11508904 G/T cg17822314 chr2:54198336 PSME4 0.42 6.51 0.34 2.83e-10 Schizophrenia; CRC cis rs4555082 0.874 rs113291192 chr14:105738181 C/T cg18132624 chr14:105716052 BTBD6;BRF1 -0.47 -7.62 -0.39 2.8e-13 Mean platelet volume;Platelet distribution width; CRC cis rs11105298 0.891 rs10858900 chr12:89925081 C/A cg00757033 chr12:89920650 WDR51B 0.38 6.21 0.32 1.62e-9 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; CRC trans rs4650994 0.525 rs4457535 chr1:178497186 C/T cg27649806 chr9:35101217 STOML2 -0.38 -6.07 -0.32 3.44e-9 HDL cholesterol levels;HDL cholesterol; CRC cis rs2274273 0.624 rs7140628 chr14:55760681 A/C cg10130446 chr14:55658398 DLGAP5 -0.4 -5.66 -0.3 3.28e-8 Protein biomarker; CRC cis rs4148883 0.651 rs10020052 chr4:100086331 C/G cg12011299 chr4:100065546 ADH4 0.5 10.97 0.52 4.61e-24 Alcohol dependence; CRC cis rs13098911 0.540 rs9824651 chr3:46108285 C/T cg12691230 chr3:46064611 XCR1 -0.53 -6.09 -0.32 3.17e-9 Celiac disease; CRC cis rs6951245 0.572 rs11559183 chr7:1037025 C/A cg21664854 chr7:1097933 C7orf50;GPR146 0.73 5.7 0.3 2.69e-8 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs13315871 0.929 rs17059171 chr3:58302586 A/G cg20936604 chr3:58311152 NA -0.71 -7.58 -0.39 3.55e-13 Cholesterol, total; CRC cis rs7618915 0.571 rs6798246 chr3:52599922 G/A cg18404041 chr3:52824283 ITIH1 -0.43 -8.97 -0.44 2.23e-17 Bipolar disorder; CRC cis rs28386778 0.897 rs2727330 chr17:61925498 A/G cg22520471 chr17:61851767 DDX42;CCDC47 -0.7 -10.99 -0.52 3.78e-24 Prudent dietary pattern; CRC cis rs4144027 0.967 rs10133399 chr14:104361843 A/T cg08213375 chr14:104286397 PPP1R13B 0.38 6.73 0.35 7.61e-11 Blood metabolite levels; CRC cis rs5758511 0.680 rs5758682 chr22:42645202 C/T cg00645731 chr22:42541494 CYP2D7P1 0.67 10.37 0.5 5.41e-22 Birth weight; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg06659009 chr4:95129138 SMARCAD1 0.4 6.62 0.34 1.42e-10 Liver disease severity in Alagille syndrome; CRC trans rs10982213 0.830 rs2274163 chr9:117188714 C/T cg06569271 chr3:186501246 EIF4A2;SNORD2 0.42 6.04 0.32 4.22e-9 Interleukin-6 levels; CRC cis rs9611565 0.765 rs767593 chr22:41779971 G/T cg06481639 chr22:41940642 POLR3H -0.52 -5.89 -0.31 9.53e-9 Vitiligo; CRC cis rs713477 0.967 rs8009706 chr14:55914756 A/G cg13175173 chr14:55914753 NA -0.52 -9.94 -0.48 1.57e-20 Pediatric bone mineral content (femoral neck); CRC cis rs3020333 0.875 rs3020331 chr6:152008780 C/T cg22157087 chr6:152012887 ESR1 0.52 7.76 0.39 1.08e-13 Total body bone mineral density; CRC cis rs9916302 0.904 rs57399933 chr17:37551189 A/G cg00129232 chr17:37814104 STARD3 0.54 8.12 0.41 9.26e-15 Glomerular filtration rate (creatinine); CRC trans rs61931739 0.500 rs12832312 chr12:34031199 G/A cg26384229 chr12:38710491 ALG10B 0.53 6.72 0.35 8.12e-11 Morning vs. evening chronotype; CRC trans rs2797160 0.967 rs1739368 chr6:126011079 C/T cg05039488 chr6:79577232 IRAK1BP1 0.49 7.18 0.37 4.57e-12 Endometrial cancer; CRC cis rs17209837 1.000 rs45593435 chr7:87088772 A/G cg00919237 chr7:87102261 ABCB4 -0.49 -6.03 -0.32 4.4e-9 Gallbladder cancer; CRC trans rs9858542 0.953 rs6446272 chr3:49463287 G/A cg21665057 chr3:196295764 WDR53;FBXO45 -0.64 -8.83 -0.44 6.34e-17 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs910316 0.967 rs175451 chr14:75589729 C/T cg11812906 chr14:75593930 NEK9 -0.57 -8.94 -0.44 2.76e-17 Height; CRC cis rs9549367 0.789 rs2316442 chr13:113877487 C/T cg18105134 chr13:113819100 PROZ -0.73 -10.92 -0.52 6.68e-24 Platelet distribution width; CRC cis rs55665837 1.000 rs10832257 chr11:14443316 A/G cg19336497 chr11:14380999 RRAS2 -0.39 -6.61 -0.34 1.58e-10 Vitamin D levels; CRC cis rs73206853 0.764 rs17682012 chr12:111094454 A/G cg12870014 chr12:110450643 ANKRD13A -0.8 -7.93 -0.4 3.42e-14 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC cis rs9649213 0.613 rs7777415 chr7:97959214 A/T cg08684580 chr7:98029266 BAIAP2L1 -0.32 -5.67 -0.3 3.07e-8 Prostate cancer (SNP x SNP interaction); CRC cis rs7618501 0.633 rs6446193 chr3:50059758 T/C cg05623727 chr3:50126028 RBM5 -0.43 -7.3 -0.37 2.21e-12 Intelligence (multi-trait analysis); CRC cis rs7772486 0.738 rs2246334 chr6:146183635 G/A cg23711669 chr6:146136114 FBXO30 0.73 12.52 0.57 1.14e-29 Lobe attachment (rater-scored or self-reported); CRC cis rs4474465 0.688 rs7937225 chr11:78278126 T/A cg27205649 chr11:78285834 NARS2 0.54 7.12 0.37 6.74e-12 Alzheimer's disease (survival time); CRC trans rs61931739 0.500 rs7488438 chr12:34531359 G/T cg26384229 chr12:38710491 ALG10B 0.68 8.8 0.44 7.69e-17 Morning vs. evening chronotype; CRC cis rs2204008 0.603 rs4397954 chr12:38089157 T/C cg13010199 chr12:38710504 ALG10B 0.46 5.63 0.3 3.87e-8 Bladder cancer; CRC cis rs12580194 0.593 rs61956272 chr12:55779559 A/T cg19537932 chr12:55886519 OR6C68 -0.72 -9.11 -0.45 7.95e-18 Cancer; CRC cis rs6860806 0.507 rs274572 chr5:131710917 T/G cg18301423 chr5:131593218 PDLIM4 -0.39 -6.45 -0.33 4.07e-10 Breast cancer; CRC cis rs6840360 0.606 rs2709814 chr4:152360870 T/C cg09659197 chr4:152720779 NA 0.33 6.47 0.34 3.57e-10 Intelligence (multi-trait analysis); CRC cis rs12926788 0.542 rs11862971 chr16:24767574 C/A cg04756594 chr16:24857601 SLC5A11 0.32 6.77 0.35 5.89e-11 Ejection fraction in Tripanosoma cruzi seropositivity; CRC cis rs6502050 0.799 rs6502089 chr17:80169523 G/A cg19223190 chr17:80058835 NA 0.42 6.68 0.35 1.01e-10 Life satisfaction; CRC cis rs62283056 0.512 rs4568307 chr4:6284965 A/G cg00701064 chr4:6280414 WFS1 0.61 9.02 0.45 1.55e-17 Cisplatin-induced ototoxicity; CRC trans rs783540 0.967 rs783523 chr15:83283555 A/G cg18393722 chr15:85113863 UBE2QP1 0.37 6.19 0.32 1.82e-9 Schizophrenia; CRC trans rs10506458 1.000 rs12425655 chr12:63434463 C/T cg03429785 chr15:59498649 MYO1E;LDHAL6B -1.23 -18.42 -0.71 1.42e-52 Hemostatic factors and hematological phenotypes; CRC cis rs10791323 0.593 rs2282604 chr11:133714672 A/G cg00579200 chr11:133705235 NA -0.4 -5.77 -0.3 1.82e-8 Childhood ear infection; CRC cis rs11168351 0.927 rs7971880 chr12:48391055 C/T cg00601486 chr12:48723148 H1FNT 0.33 6.09 0.32 3.08e-9 Bipolar disorder and schizophrenia; CRC cis rs17155006 0.655 rs94604 chr7:107733856 C/T cg05962710 chr7:107745446 LAMB4 -0.35 -5.85 -0.31 1.18e-8 Pneumococcal bacteremia; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg06334988 chr2:220095083 ANKZF1;ATG9A 0.48 6.84 0.35 3.85e-11 Anxiety disorder; CRC cis rs6952808 0.601 rs3778978 chr7:2159817 A/G cg04267008 chr7:1944627 MAD1L1 -0.68 -9.3 -0.46 2.03e-18 Bipolar disorder and schizophrenia; CRC cis rs2836974 0.533 rs418298 chr21:40536654 A/T cg11644478 chr21:40555479 PSMG1 0.74 12.52 0.57 1.13e-29 Cognitive function; CRC cis rs2032447 0.802 rs198853 chr6:26104096 T/C cg12588279 chr6:26043732 HIST1H2BB -0.4 -5.66 -0.3 3.35e-8 Intelligence (multi-trait analysis); CRC cis rs6502050 0.805 rs7503095 chr17:80107354 G/A cg22110888 chr17:80059540 CCDC57 0.4 6.44 0.33 4.17e-10 Life satisfaction; CRC cis rs875971 0.862 rs6952182 chr7:65683317 T/G cg18252515 chr7:66147081 NA 0.41 5.77 0.3 1.86e-8 Aortic root size; CRC cis rs720844 0.684 rs13029692 chr2:149299202 C/G cg09247360 chr2:149335327 NA -0.58 -6.02 -0.32 4.55e-9 Peripheral arterial disease (traffic-related air pollution interaction); CRC trans rs7615952 0.576 rs4646759 chr3:125822946 G/C cg07211511 chr3:129823064 LOC729375 -0.69 -9.09 -0.45 9.31e-18 Blood pressure (smoking interaction); CRC cis rs4862750 1.000 rs4862750 chr4:187904043 C/T cg03647317 chr4:187891568 NA -0.54 -9.67 -0.47 1.26e-19 Lobe attachment (rater-scored or self-reported); CRC cis rs300703 0.515 rs440617 chr2:189818 A/G cg21211680 chr2:198530 NA -0.73 -9.44 -0.46 7.16e-19 Blood protein levels; CRC cis rs950169 0.545 rs4842841 chr15:84641125 G/A cg17507749 chr15:85114479 UBE2QP1 0.63 8.47 0.42 8.52e-16 Schizophrenia; CRC cis rs6964587 1.000 rs6944591 chr7:91642714 T/C cg17063962 chr7:91808500 NA 0.8 14.3 0.62 2.04e-36 Breast cancer; CRC cis rs17270561 0.609 rs4711094 chr6:25706174 T/A cg16482183 chr6:26056742 HIST1H1C 0.75 9.51 0.46 4.09e-19 Iron status biomarkers; CRC trans rs1455244 0.700 rs7229302 chr18:11508904 G/T cg09916155 chr16:1728187 HN1L 0.41 6.15 0.32 2.31e-9 Schizophrenia; CRC cis rs2559856 1.000 rs2695299 chr12:102082664 G/A cg12924262 chr12:102091054 CHPT1 0.55 8.2 0.41 5.56e-15 Blood protein levels; CRC cis rs34779708 0.966 rs10827487 chr10:35406878 T/A cg03585969 chr10:35415529 CREM 0.59 7.91 0.4 4.02e-14 Inflammatory bowel disease;Crohn's disease; CRC cis rs684232 0.602 rs394747 chr17:562495 C/G cg15660573 chr17:549704 VPS53 0.86 15.87 0.66 1.61e-42 Prostate cancer; CRC trans rs877282 0.898 rs12357995 chr10:765739 T/C cg22713356 chr15:30763199 NA 1.3 15.02 0.64 3.32e-39 Uric acid levels; CRC cis rs270601 0.739 rs1979981 chr5:131601720 G/A cg24060327 chr5:131705240 SLC22A5 -0.4 -6.22 -0.32 1.49e-9 Acylcarnitine levels; CRC cis rs919433 0.783 rs787979 chr2:198242868 A/T cg03934865 chr2:198174659 NA 0.34 5.66 0.3 3.34e-8 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC cis rs11098499 0.657 rs7664458 chr4:120371967 A/G cg09307838 chr4:120376055 NA 0.72 11.14 0.52 1.1e-24 Corneal astigmatism; CRC cis rs546131 0.928 rs553789 chr11:34827579 G/A cg06937548 chr11:34938143 PDHX;APIP 0.4 6.07 0.32 3.48e-9 Lung disease severity in cystic fibrosis; CRC cis rs892961 0.932 rs9916143 chr17:75409282 C/G cg05865280 chr17:75406074 SEPT9 -0.64 -14.92 -0.64 8.42e-39 Airflow obstruction; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg16211334 chr6:10695274 C6orf52;PAK1IP1 0.42 7.02 0.36 1.27e-11 Liver disease severity in Alagille syndrome; CRC cis rs2842992 0.724 rs1128670 chr6:160211636 G/A cg19482086 chr6:160211437 TCP1;MRPL18 0.84 13.56 0.6 1.38e-33 Age-related macular degeneration (geographic atrophy); CRC cis rs4073582 0.595 rs1151540 chr11:66041807 A/C cg14036092 chr11:66035641 RAB1B 0.57 9.23 0.45 3.38e-18 Gout; CRC cis rs2153535 0.601 rs969420 chr6:8451966 T/A cg07606381 chr6:8435919 SLC35B3 0.68 10.85 0.51 1.2e-23 Motion sickness; CRC cis rs270601 0.633 rs4535443 chr5:131572561 A/G cg18758796 chr5:131593413 PDLIM4 0.52 8.95 0.44 2.64e-17 Acylcarnitine levels; CRC cis rs769267 0.965 rs2965188 chr19:19522557 G/A cg01262667 chr19:19385393 TM6SF2 0.38 6.39 0.33 5.6e-10 Tonsillectomy; CRC cis rs733592 0.599 rs12819124 chr12:48409054 G/T cg15465823 chr12:48382534 COL2A1 0.37 6.3 0.33 9.66e-10 Plateletcrit; CRC cis rs2120019 1.000 rs7173833 chr15:75369618 C/T cg17294928 chr15:75287854 SCAMP5 -0.66 -9.52 -0.46 3.99e-19 Blood trace element (Zn levels); CRC cis rs4363385 0.747 rs61811427 chr1:152968419 C/T cg25856811 chr1:152973957 SPRR3 -0.27 -7.35 -0.38 1.57e-12 Inflammatory skin disease; CRC cis rs863345 0.604 rs11265015 chr1:158503252 G/A cg12129480 chr1:158549410 OR10X1 -0.3 -6.28 -0.33 1.09e-9 Pneumococcal bacteremia; CRC cis rs6662572 0.737 rs11587648 chr1:46585418 G/A cg08644498 chr1:46502608 NA 0.43 7.01 0.36 1.32e-11 Blood protein levels; CRC cis rs765787 0.530 rs55771002 chr15:45541566 T/C cg24006582 chr15:45444508 DUOX1 -0.57 -8.63 -0.43 2.62e-16 Uric acid levels; CRC cis rs6063312 0.667 rs9679994 chr20:47281853 T/C cg18078177 chr20:47281410 PREX1 0.69 10.28 0.49 1.13e-21 Tonometry; CRC cis rs7584330 0.666 rs937386 chr2:238364039 C/T cg16989719 chr2:238392110 NA -0.4 -6.69 -0.35 9.55e-11 Prostate cancer; CRC cis rs4730250 0.708 rs74983157 chr7:106823951 A/G cg02696742 chr7:106810147 HBP1 -0.61 -6.72 -0.35 8e-11 Osteoarthritis; CRC cis rs1997103 1.000 rs4948011 chr7:55403859 A/G cg17469321 chr7:55412551 NA 0.67 11.04 0.52 2.64e-24 QRS interval (sulfonylurea treatment interaction); CRC cis rs3790455 0.610 rs1185700 chr1:156450719 G/A cg14087168 chr1:156450669 MEF2D -0.38 -6.56 -0.34 2.06e-10 Migraine; CRC cis rs1577917 0.655 rs7742691 chr6:86278691 T/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A 0.57 7.91 0.4 4.01e-14 Response to antipsychotic treatment; CRC cis rs10911232 0.507 rs10911195 chr1:182993438 T/C ch.1.3577855R chr1:183094577 LAMC1 0.86 15.15 0.64 1.1e-39 Hypertriglyceridemia; CRC cis rs2295359 0.892 rs12029362 chr1:67624231 G/A cg03340356 chr1:67600835 NA 0.29 6.44 0.33 4.34e-10 Psoriasis; CRC cis rs9837602 1.000 rs923470 chr3:99757792 G/A cg07805332 chr3:99536008 MIR548G;C3orf26 -0.48 -6.34 -0.33 7.79e-10 Breast cancer; CRC cis rs72717009 0.825 rs12746613 chr1:161467042 A/G cg10431340 chr1:161279108 MPZ 0.56 7.28 0.37 2.52e-12 Rheumatoid arthritis; CRC cis rs1218582 0.772 rs6699043 chr1:154913021 T/C cg06221963 chr1:154839813 KCNN3 -0.75 -14.78 -0.63 2.78e-38 Prostate cancer; CRC cis rs449789 0.857 rs579533 chr6:159715203 C/T cg14500486 chr6:159655392 FNDC1 -0.48 -7.29 -0.37 2.38e-12 Pulse pressure; CRC trans rs4650994 0.967 rs4650998 chr1:178531850 G/A cg05059571 chr16:84539110 KIAA1609 -0.44 -6.71 -0.35 8.56e-11 HDL cholesterol levels;HDL cholesterol; CRC cis rs1670533 1.000 rs10084889 chr4:1053815 G/A cg27284194 chr4:1044797 NA 0.5 6.2 0.32 1.66e-9 Recombination rate (females); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg03758392 chr3:184870408 C3orf70 0.43 6.13 0.32 2.46e-9 Response to antipsychotic treatment; CRC cis rs3749237 0.595 rs6797765 chr3:49423976 A/G cg03060546 chr3:49711283 APEH 0.64 10.92 0.52 7.04e-24 Resting heart rate; CRC cis rs7259376 0.936 rs11085524 chr19:22536422 G/C cg02657401 chr19:22469223 NA -0.33 -7.46 -0.38 7.6e-13 Menopause (age at onset); CRC cis rs4713118 0.513 rs149897 chr6:28006650 A/G cg12172441 chr6:28176163 NA 0.52 7.26 0.37 2.77e-12 Parkinson's disease; CRC trans rs7395662 1.000 rs6485888 chr11:48605339 A/T cg21153622 chr11:89784906 NA -0.48 -7.67 -0.39 1.95e-13 HDL cholesterol; CRC cis rs9868809 0.881 rs3806694 chr3:48672334 G/C cg00383909 chr3:49044727 WDR6 0.76 7.63 0.39 2.48e-13 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; CRC cis rs7666738 0.830 rs7669407 chr4:98750251 G/A cg17366294 chr4:99064904 C4orf37 0.42 6.91 0.36 2.59e-11 Colonoscopy-negative controls vs population controls; CRC cis rs6952808 0.771 rs10950415 chr7:1914477 A/G cg04267008 chr7:1944627 MAD1L1 -0.63 -9.75 -0.47 6.59e-20 Bipolar disorder and schizophrenia; CRC cis rs4728142 0.604 rs6969930 chr7:128630313 T/C cg06630958 chr7:128577819 IRF5 -0.35 -5.65 -0.3 3.39e-8 Inflammatory bowel disease;Systemic lupus erythematosus;Ulcerative colitis; CRC cis rs59104589 0.550 rs12612038 chr2:242369685 A/G cg19488206 chr2:242435732 STK25 0.48 7.05 0.36 1.04e-11 Fibrinogen levels; CRC cis rs17401966 0.838 rs10864449 chr1:10296922 A/T cg19773385 chr1:10388646 KIF1B -0.66 -10.78 -0.51 2.04e-23 Hepatocellular carcinoma; CRC cis rs1005277 0.579 rs2474572 chr10:38385316 A/G cg00409905 chr10:38381863 ZNF37A -0.66 -11.29 -0.53 3.37e-25 Extrinsic epigenetic age acceleration; CRC cis rs3820068 0.603 rs998032 chr1:15989918 T/C cg13390004 chr1:15929781 NA 0.52 7.28 0.37 2.49e-12 Systolic blood pressure; CRC cis rs7043114 0.563 rs987554 chr9:95298738 A/G cg13798575 chr9:95087839 CENPP;NOL8 -0.39 -5.72 -0.3 2.46e-8 Height; CRC cis rs7894051 1.000 rs4345885 chr10:135191311 T/C cg24905316 chr10:135186343 ECHS1 0.74 6.63 0.34 1.37e-10 Lifespan; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg24786579 chr12:32832461 DNM1L 0.45 6.23 0.32 1.41e-9 Anxiety disorder; CRC cis rs56091001 0.528 rs9616387 chr22:50313219 G/A cg02269571 chr22:50332266 NA -1.27 -12.38 -0.56 3.83e-29 Acne (severe); CRC cis rs916888 0.610 rs199452 chr17:44801340 C/T cg01570182 chr17:44337453 NA 0.73 9.49 0.46 4.87e-19 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs2084637 0.965 rs12223035 chr11:122410565 G/C cg21585512 chr11:122030076 LOC399959 -0.38 -6.73 -0.35 7.6e-11 Stroke; CRC cis rs910187 0.571 rs3746490 chr20:45801712 G/A cg27589058 chr20:45804311 EYA2 -0.44 -8.54 -0.43 5.18e-16 Migraine; CRC trans rs7819412 0.691 rs73198970 chr8:11040216 T/C cg06636001 chr8:8085503 FLJ10661 -0.47 -7.13 -0.37 6.35e-12 Triglycerides; CRC cis rs10504229 0.683 rs61241336 chr8:58106585 A/G cg02725872 chr8:58115012 NA -0.66 -11.36 -0.53 1.85e-25 Developmental language disorder (linguistic errors); CRC cis rs10504229 0.683 rs35889486 chr8:58117749 T/A cg02290350 chr8:58132656 NA -0.58 -8.16 -0.41 7.29e-15 Developmental language disorder (linguistic errors); CRC cis rs11098499 0.722 rs28713555 chr4:120251995 C/T cg09307838 chr4:120376055 NA 0.61 9.59 0.47 2.22e-19 Corneal astigmatism; CRC cis rs2797160 0.905 rs1418640 chr6:125999866 G/A cg05901451 chr6:126070800 HEY2 -0.38 -5.93 -0.31 7.46e-9 Endometrial cancer; CRC cis rs2652834 1.000 rs34575783 chr15:63397686 G/C cg05507819 chr15:63340323 TPM1 0.47 5.97 0.31 6.31e-9 HDL cholesterol; CRC cis rs6424115 0.679 rs2267961 chr1:24071048 A/G cg08896387 chr1:24191740 FUCA1 0.45 5.67 0.3 3.18e-8 Immature fraction of reticulocytes; CRC cis rs7552404 0.824 rs1251077 chr1:76189745 C/G cg22875332 chr1:76189707 ACADM -0.77 -13.4 -0.59 5.84e-33 Blood metabolite levels;Acylcarnitine levels; CRC cis rs3736485 0.966 rs8042840 chr15:51908498 C/T cg08986416 chr15:51914746 DMXL2 -0.49 -6.93 -0.36 2.23e-11 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs4660261 0.526 rs2906466 chr1:44322220 A/G cg12908607 chr1:44402522 ARTN -0.52 -9.44 -0.46 7.16e-19 Intelligence (multi-trait analysis); CRC cis rs875971 0.964 rs160635 chr7:65528918 T/C cg11764359 chr7:65958608 NA 0.58 9.1 0.45 9.09e-18 Aortic root size; CRC cis rs853679 0.550 rs1150692 chr6:28173957 A/G cg12172441 chr6:28176163 NA 0.65 8.59 0.43 3.46e-16 Depression; CRC cis rs2124969 0.548 rs72979963 chr2:161014483 A/G cg03641300 chr2:160917029 PLA2R1 -0.65 -8.34 -0.42 2.08e-15 Waist circumference adjusted for body mass index; CRC cis rs7487075 0.859 rs7974529 chr12:46751388 A/G cg22049899 chr12:47219821 SLC38A4 0.34 6.76 0.35 6.13e-11 Itch intensity from mosquito bite; CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg01802975 chr1:67519155 SLC35D1 0.37 6.04 0.32 4.25e-9 Obesity-related traits; CRC cis rs875971 0.545 rs73146609 chr7:65767464 A/G cg05627663 chr7:65219948 SNORA22;CCT6P1 0.61 7.93 0.4 3.53e-14 Aortic root size; CRC cis rs7215564 0.908 rs2873060 chr17:78663497 A/C cg09596252 chr17:78655493 RPTOR 0.54 6.08 0.32 3.26e-9 Myopia (pathological); CRC cis rs10489202 0.683 rs202260 chr1:167956167 G/T cg24449463 chr1:168025552 DCAF6 -0.58 -8.86 -0.44 5.15e-17 Schizophrenia; CRC cis rs1008375 1.000 rs4698641 chr4:17642630 C/T cg04450456 chr4:17643702 FAM184B 0.36 5.85 0.31 1.18e-8 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs7618915 0.524 rs2028216 chr3:52680823 C/T cg08222913 chr3:52553049 STAB1 -0.34 -6.12 -0.32 2.7e-9 Bipolar disorder; CRC cis rs67478160 0.608 rs11628787 chr14:104323984 G/A cg08213375 chr14:104286397 PPP1R13B -0.59 -11.92 -0.55 1.83e-27 Schizophrenia; CRC cis rs6500602 0.647 rs3747600 chr16:4586222 A/G cg08645402 chr16:4508243 NA 0.63 11.1 0.52 1.59e-24 Schizophrenia; CRC cis rs1153858 1.000 rs4775907 chr15:45638647 G/A cg14582100 chr15:45693742 SPATA5L1 0.28 5.87 0.31 1.07e-8 Homoarginine levels; CRC cis rs8072100 0.817 rs6505049 chr17:45675781 G/A cg25173405 chr17:45401733 C17orf57 0.41 6.3 0.33 9.31e-10 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs62244186 0.593 rs9814298 chr3:44871899 T/A cg10263370 chr3:44754102 ZNF502 -0.36 -6.05 -0.32 3.97e-9 Depressive symptoms; CRC cis rs11122272 0.735 rs2011357 chr1:231480208 A/G cg06096015 chr1:231504339 EGLN1 0.41 6.05 0.32 3.93e-9 Hemoglobin concentration; CRC cis rs10504229 0.683 rs11774847 chr8:58140775 T/A cg22535103 chr8:58192502 C8orf71 -0.8 -8.99 -0.44 2.05e-17 Developmental language disorder (linguistic errors); CRC trans rs61931739 0.500 rs7311284 chr12:34478477 C/G cg26384229 chr12:38710491 ALG10B 0.67 8.83 0.44 6.26e-17 Morning vs. evening chronotype; CRC cis rs16867321 0.806 rs1453060 chr2:181330763 C/A cg23363182 chr2:181467187 NA -0.51 -5.93 -0.31 7.64e-9 Obesity; CRC cis rs921968 0.508 rs72965103 chr2:219312469 T/C cg02176678 chr2:219576539 TTLL4 -0.57 -9.12 -0.45 7.52e-18 Mean corpuscular hemoglobin concentration; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg04691425 chr12:96252524 SNRPF 0.49 6.88 0.35 2.95e-11 Response to antipsychotic treatment; CRC cis rs6543140 0.964 rs4851578 chr2:103028951 T/G cg03938978 chr2:103052716 IL18RAP 0.46 7.15 0.37 5.82e-12 Blood protein levels; CRC cis rs4665809 0.590 rs11552518 chr2:26455127 G/A cg04944784 chr2:26401820 FAM59B 0.85 11.05 0.52 2.29e-24 Gut microbiome composition (summer); CRC cis rs2204008 0.837 rs11168341 chr12:37961951 C/T cg13010199 chr12:38710504 ALG10B 0.44 5.63 0.3 3.86e-8 Bladder cancer; CRC cis rs6540559 0.673 rs11803382 chr1:209986426 G/A cg25204440 chr1:209979598 IRF6 0.48 5.77 0.3 1.82e-8 Cleft lip with or without cleft palate; CRC cis rs863345 0.647 rs923663 chr1:158507732 A/T cg12129480 chr1:158549410 OR10X1 0.3 6.27 0.33 1.13e-9 Pneumococcal bacteremia; CRC cis rs2932538 0.885 rs6661642 chr1:113090109 T/C cg22162597 chr1:113214053 CAPZA1 0.7 9.99 0.48 1.07e-20 Systolic blood pressure;Diastolic blood pressure;Hypertension;Blood pressure; CRC cis rs9611565 0.694 rs202631 chr22:41863423 A/G cg06481639 chr22:41940642 POLR3H 0.51 6.28 0.33 1.1e-9 Vitiligo; CRC cis rs6502050 0.835 rs4789675 chr17:80123144 G/A cg09264619 chr17:80180166 NA -0.35 -5.93 -0.31 7.47e-9 Life satisfaction; CRC cis rs7727544 0.716 rs11955347 chr5:131567924 G/A cg09877947 chr5:131593287 PDLIM4 0.36 6.59 0.34 1.71e-10 Blood metabolite levels; CRC trans rs1814175 0.817 rs1615305 chr11:49895222 T/A cg15704280 chr7:45808275 SEPT13 -1.02 -20.55 -0.75 6.02e-61 Height; CRC cis rs7095944 0.614 rs10901817 chr10:126443404 A/T cg08799069 chr10:126477246 METTL10 -0.44 -6.84 -0.35 3.81e-11 Asthma; CRC cis rs7301826 0.651 rs10848210 chr12:131312020 G/A cg11011512 chr12:131303247 STX2 0.38 5.7 0.3 2.69e-8 Plasma plasminogen activator levels; CRC cis rs2799081 1 rs2799081 chr6:28270584 T/C cg06470822 chr6:28175283 NA 0.45 5.98 0.31 5.71e-9 Myopia; CRC cis rs853679 0.517 rs9393896 chr6:28127703 C/T cg06470822 chr6:28175283 NA 1.03 13.59 0.6 1.04e-33 Depression; CRC cis rs9682041 0.867 rs6444925 chr3:170123358 G/T cg11886554 chr3:170076028 SKIL 1.06 10.83 0.51 1.44e-23 Glomerular filtration rate in non diabetics (creatinine);Glomerular filtration rate (creatinine); CRC trans rs11165623 0.564 rs9887897 chr1:96996671 T/C cg10631902 chr5:14652156 NA -0.4 -6.97 -0.36 1.75e-11 Hip circumference;Waist circumference; CRC cis rs3752962 0.569 rs12451788 chr17:1941048 C/T cg24156229 chr17:1948635 NA 0.77 14.78 0.63 2.79e-38 Itch intensity from mosquito bite; CRC cis rs826838 0.967 rs4768329 chr12:39129394 T/C cg13010199 chr12:38710504 ALG10B -0.41 -5.8 -0.3 1.59e-8 Heart rate; CRC cis rs1062746 0.558 rs889608 chr16:87337543 A/G cg02258303 chr16:87377426 FBXO31 -0.53 -8.18 -0.41 6.43e-15 Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 2 peripheral neuropathy); CRC cis rs9486719 1.000 rs4078038 chr6:96904366 A/G cg06623918 chr6:96969491 KIAA0776 -0.82 -9.53 -0.47 3.67e-19 Migraine;Coronary artery disease; CRC trans rs10504229 1.000 rs72650900 chr8:58185675 T/A cg04077850 chr5:125800366 GRAMD3 0.37 6.27 0.33 1.15e-9 Developmental language disorder (linguistic errors); CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg25373372 chr6:82462656 FAM46A -0.39 -6.09 -0.32 3.24e-9 Obesity-related traits; CRC cis rs7605827 0.729 rs35131126 chr2:15537730 A/G cg19274914 chr2:15703543 NA 0.4 5.94 0.31 7.2e-9 Educational attainment (years of education); CRC cis rs7512552 0.839 rs2264418 chr1:150368579 G/A cg15654264 chr1:150340011 RPRD2 0.59 8.65 0.43 2.26e-16 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); CRC cis rs7762018 1.000 rs4716375 chr6:170071218 A/C cg24289452 chr6:170231220 NA -0.57 -6.21 -0.32 1.6e-9 Thiazide-induced adverse metabolic effects in hypertensive patients; CRC cis rs951366 0.789 rs1772148 chr1:205704580 A/T cg11965913 chr1:205819406 PM20D1 0.81 12.99 0.58 1.94e-31 Menarche (age at onset); CRC cis rs7945705 0.692 rs2742470 chr11:9004002 C/T cg00186954 chr11:8933980 ST5;C11orf17 -0.45 -7.47 -0.38 7.3e-13 Hemoglobin concentration; CRC cis rs853679 0.546 rs200953 chr6:27837267 T/C cg23259851 chr6:27775964 HIST1H2AI;HIST1H2BL 0.67 5.73 0.3 2.26e-8 Depression; CRC cis rs2067615 0.899 rs4964188 chr12:107100717 T/C cg13491945 chr12:107078410 RFX4 0.33 5.62 0.3 4.18e-8 Heart rate; CRC cis rs3812762 0.912 rs4929936 chr11:8792622 C/T cg21881798 chr11:8931708 C11orf17;ST5 -0.41 -5.93 -0.31 7.57e-9 Hypospadias; CRC cis rs7666738 0.800 rs1559858 chr4:99024075 A/G cg05340658 chr4:99064831 C4orf37 0.58 8.9 0.44 3.83e-17 Colonoscopy-negative controls vs population controls; CRC cis rs6866344 0.570 rs6896799 chr5:178147014 G/C cg03877680 chr5:178157825 ZNF354A 0.8 11.39 0.53 1.43e-25 Neutrophil percentage of white cells; CRC cis rs9443645 0.901 rs9443638 chr6:79720867 T/A cg09184832 chr6:79620586 NA -0.51 -9.28 -0.46 2.3e-18 Intelligence (multi-trait analysis); CRC cis rs887829 0.569 rs6431628 chr2:234647478 A/G cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.45 -7.07 -0.36 9.09e-12 Metabolic traits;Bilirubin levels;Cholelithiasis-related traits in sickle cell anemia;Metabolite levels;Total bilirubin levels in HIV-1 infection;Serum metabolite levels;Blood metabolite levels; CRC cis rs72945132 0.882 rs11235953 chr11:70184937 C/T cg00319359 chr11:70116639 PPFIA1 0.65 7.24 0.37 3.14e-12 Coronary artery disease; CRC cis rs13118159 0.509 rs1882098 chr4:1352431 T/C cg20887711 chr4:1340912 KIAA1530 0.75 10.86 0.51 1.08e-23 Longevity; CRC trans rs2303319 0.504 rs62189041 chr2:162599506 T/C cg22627826 chr19:1240265 ATP5D -0.72 -6.24 -0.33 1.32e-9 Cognitive function; CRC cis rs7927771 0.524 rs3758655 chr11:47703943 T/C cg20307385 chr11:47447363 PSMC3 0.46 6.7 0.35 8.98e-11 Subjective well-being; CRC cis rs1801251 1.000 rs12987513 chr2:233622066 A/G cg25237894 chr2:233734115 C2orf82 0.5 8.22 0.41 4.87e-15 Coronary artery disease; CRC cis rs875971 0.862 rs7796162 chr7:65745758 T/C cg18252515 chr7:66147081 NA 0.4 5.66 0.3 3.36e-8 Aortic root size; CRC cis rs709400 0.859 rs7693 chr14:104023704 C/T cg01849466 chr14:104193079 ZFYVE21 0.44 6.9 0.36 2.71e-11 Body mass index; CRC cis rs1555322 0.530 rs2250205 chr20:33867924 C/T cg03689076 chr20:33865952 NA 0.43 6.02 0.32 4.62e-9 Attention deficit hyperactivity disorder; CRC cis rs67311347 0.910 rs7651204 chr3:40512835 C/T cg09455208 chr3:40491958 NA -0.47 -9.3 -0.46 2.02e-18 Renal cell carcinoma; CRC trans rs7944735 0.507 rs7934659 chr11:48066374 C/T cg03929089 chr4:120376271 NA 0.52 7.04 0.36 1.1e-11 Intraocular pressure; CRC cis rs644799 0.687 rs11021318 chr11:95522996 T/C cg03916912 chr11:95522834 CEP57;FAM76B 0.86 15.85 0.66 1.93e-42 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg08724901 chr15:89089781 DET1 0.47 6.09 0.32 3.14e-9 Thyroid stimulating hormone; CRC cis rs6545883 0.895 rs2442029 chr2:61679552 G/T cg15711740 chr2:61764176 XPO1 -0.44 -5.81 -0.31 1.45e-8 Tuberculosis; CRC cis rs951366 0.617 rs823075 chr1:205774897 C/T cg11965913 chr1:205819406 PM20D1 1.03 19.83 0.74 3.98e-58 Menarche (age at onset); CRC cis rs951366 0.789 rs823094 chr1:205689807 G/T cg24739457 chr1:205821442 NA -0.38 -5.71 -0.3 2.58e-8 Menarche (age at onset); CRC cis rs7809950 1.000 rs3801944 chr7:107255548 T/C cg23024343 chr7:107201750 COG5 0.6 8.61 0.43 3.08e-16 Coronary artery disease; CRC cis rs1552244 0.935 rs66493421 chr3:10092569 G/A cg02579736 chr3:10068473 FANCD2;CIDECP 1.01 11.46 0.53 8.44e-26 Alzheimer's disease; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg01250046 chr11:6704297 MRPL17 0.52 7.47 0.38 7.08e-13 Response to antipsychotic treatment; CRC trans rs7395662 0.750 rs10838985 chr11:48645085 A/G cg21153622 chr11:89784906 NA -0.42 -6.57 -0.34 1.97e-10 HDL cholesterol; CRC cis rs734999 0.588 rs2843403 chr1:2529097 T/C cg20673091 chr1:2541236 MMEL1 -0.36 -5.82 -0.31 1.39e-8 Ulcerative colitis; CRC cis rs12760731 0.720 rs6702625 chr1:178339206 G/A cg00404053 chr1:178313656 RASAL2 0.85 10.34 0.5 6.68e-22 Obesity-related traits; CRC cis rs9916302 0.904 rs10432031 chr17:37397852 G/A cg03013999 chr17:37608204 MED1 0.47 7.15 0.37 5.71e-12 Glomerular filtration rate (creatinine); CRC trans rs1814175 0.645 rs28445479 chr11:50047999 A/G cg11707556 chr5:10655725 ANKRD33B -0.52 -10.16 -0.49 2.82e-21 Height; CRC cis rs2302190 0.882 rs11650105 chr17:56588072 C/T cg25885038 chr17:56607967 SEPT4 -0.53 -8.17 -0.41 6.75e-15 Vitamin D levels; CRC cis rs4660306 0.677 rs1006215 chr1:45909945 T/A cg03123370 chr1:45965343 CCDC163P;MMACHC 0.5 6.64 0.34 1.32e-10 Homocysteine levels; CRC cis rs11122272 0.735 rs2808583 chr1:231512587 G/C cg06096015 chr1:231504339 EGLN1 0.4 6.08 0.32 3.37e-9 Hemoglobin concentration; CRC cis rs9303401 0.659 rs66514313 chr17:56714057 C/T cg02118635 chr17:56770003 RAD51C;TEX14 0.79 9.9 0.48 2.16e-20 Cognitive test performance; CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg07131166 chr7:138089188 NA -0.42 -7.1 -0.36 7.77e-12 Obesity-related traits; CRC cis rs3741404 0.791 rs7102177 chr11:63909228 T/C cg05016508 chr11:63871570 FLRT1;MACROD1 0.44 6.53 0.34 2.55e-10 Platelet count; CRC cis rs2252521 0.689 rs989851 chr7:29081849 G/C cg11728747 chr7:29037910 CPVL -0.33 -6.16 -0.32 2.12e-9 Cognitive performance; CRC cis rs9549328 0.670 rs2993344 chr13:113617022 C/T cg20742385 chr13:113633654 MCF2L 0.56 9.56 0.47 2.94e-19 Systolic blood pressure; CRC cis rs7647973 0.710 rs11130207 chr3:49611666 T/G cg03060546 chr3:49711283 APEH 0.66 7.37 0.38 1.41e-12 Menarche (age at onset); CRC cis rs7762018 0.607 rs75010113 chr6:170057441 C/T cg19338460 chr6:170058176 WDR27 -1.2 -11.23 -0.53 5.58e-25 Thiazide-induced adverse metabolic effects in hypertensive patients; CRC cis rs863345 0.526 rs857718 chr1:158595142 T/A cg12129480 chr1:158549410 OR10X1 -0.29 -6.31 -0.33 8.95e-10 Pneumococcal bacteremia; CRC cis rs11758351 1.000 rs75921373 chr6:26191843 C/T cg22723502 chr6:26240528 HIST1H4F -0.37 -5.78 -0.3 1.74e-8 Gout;Renal underexcretion gout; CRC cis rs7209700 0.662 rs8074094 chr17:45348021 T/C cg08085267 chr17:45401833 C17orf57 0.44 5.97 0.31 6.01e-9 IgG glycosylation; CRC cis rs12545109 0.800 rs1467123 chr8:57418870 C/T cg09654669 chr8:57350985 NA -0.45 -7.22 -0.37 3.69e-12 Obesity-related traits; CRC cis rs12431939 0.626 rs7350715 chr14:51717060 C/A cg23942311 chr14:51606299 NA 0.54 6.95 0.36 1.93e-11 Cancer; CRC cis rs9816226 0.618 rs869399 chr3:185826764 C/T cg00760338 chr3:185826511 ETV5 0.79 10.97 0.52 4.35e-24 Obesity;Body mass index; CRC trans rs10982213 0.830 rs2274163 chr9:117188714 C/T cg10902427 chr5:176944034 DDX41 0.38 6.14 0.32 2.4e-9 Interleukin-6 levels; CRC cis rs1997103 1.000 rs6950311 chr7:55400990 G/A cg17469321 chr7:55412551 NA 0.73 11.31 0.53 2.87e-25 QRS interval (sulfonylurea treatment interaction); CRC cis rs7945705 0.692 rs2742470 chr11:9004002 C/T cg14711859 chr11:8959438 ASCL3 0.38 6.4 0.33 5.21e-10 Hemoglobin concentration; CRC cis rs3857536 0.741 rs9363558 chr6:66937260 C/T cg07460842 chr6:66804631 NA -0.43 -5.81 -0.3 1.48e-8 Blood trace element (Cu levels); CRC cis rs7412746 0.658 rs72704682 chr1:150897677 A/T cg10589385 chr1:150898437 SETDB1 0.32 6.87 0.35 3.16e-11 Melanoma; CRC cis rs875971 0.862 rs10276077 chr7:65728411 A/G cg11764359 chr7:65958608 NA -0.61 -9.35 -0.46 1.35e-18 Aortic root size; CRC cis rs4332037 0.802 rs12113633 chr7:1932936 G/A cg21155852 chr7:2048760 MAD1L1 -0.5 -6.84 -0.35 3.78e-11 Bipolar disorder; CRC cis rs11574514 1.000 rs8058835 chr16:67814865 C/T cg26727032 chr16:67993705 SLC12A4 -0.62 -6.04 -0.32 4.14e-9 Crohn's disease; CRC cis rs1862618 0.525 rs2662021 chr5:56261691 C/T cg18230493 chr5:56204884 C5orf35 0.77 10.32 0.49 7.81e-22 Initial pursuit acceleration; CRC cis rs7762018 0.891 rs7740218 chr6:170141552 G/A cg19338460 chr6:170058176 WDR27 -0.71 -7.8 -0.4 8.04e-14 Thiazide-induced adverse metabolic effects in hypertensive patients; CRC cis rs12188164 0.931 rs115554641 chr5:443236 C/G cg17553881 chr5:443987 EXOC3;C5orf55 -0.37 -7.69 -0.39 1.76e-13 Cystic fibrosis severity; CRC cis rs11191419 1 rs11191419 chr10:104612335 T/A cg04362960 chr10:104952993 NT5C2 0.59 8.07 0.41 1.32e-14 Autism spectrum disorder or schizophrenia;Schizophrenia; CRC cis rs4423214 0.879 rs1792264 chr11:71150247 C/T cg05163923 chr11:71159392 DHCR7 -0.63 -7.82 -0.4 7.25e-14 Vitamin D levels; CRC cis rs2153535 0.580 rs9406163 chr6:8466642 C/T cg07606381 chr6:8435919 SLC35B3 0.68 10.9 0.51 8.26e-24 Motion sickness; CRC cis rs62458065 0.850 rs10239812 chr7:32460348 A/G cg20159608 chr7:32802032 NA -0.51 -5.92 -0.31 8.19e-9 Metabolite levels (HVA/MHPG ratio); CRC cis rs10504229 1.000 rs59549824 chr8:58186205 A/C cg01721255 chr8:58191610 C8orf71 0.49 6.07 0.32 3.59e-9 Developmental language disorder (linguistic errors); CRC cis rs4713118 0.515 rs9368549 chr6:28050047 T/A cg18032046 chr6:28092343 ZSCAN16 -0.51 -6.05 -0.32 3.87e-9 Parkinson's disease; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg04295991 chr13:21348012 N6AMT2 0.53 6.79 0.35 5.31e-11 Thyroid stimulating hormone; CRC cis rs270601 0.955 rs273911 chr5:131661526 C/G cg18301423 chr5:131593218 PDLIM4 0.38 6.39 0.33 5.7e-10 Acylcarnitine levels; CRC cis rs274567 0.550 rs272885 chr5:131667736 A/G cg02033258 chr5:131593261 PDLIM4 0.38 6.47 0.34 3.5e-10 Blood metabolite levels; CRC cis rs2204008 0.576 rs11519979 chr12:37999413 C/T cg26384229 chr12:38710491 ALG10B 0.68 8.95 0.44 2.57e-17 Bladder cancer; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg20733500 chr12:89747474 DUSP6 0.39 5.99 0.31 5.47e-9 Intelligence (multi-trait analysis); CRC cis rs10924970 1.000 rs10157739 chr1:235354555 C/G cg26050004 chr1:235667680 B3GALNT2 0.4 5.97 0.31 6.28e-9 Asthma; CRC cis rs6860806 0.507 rs272872 chr5:131675864 C/T cg11843238 chr5:131593191 PDLIM4 -0.41 -7.06 -0.36 1.01e-11 Breast cancer; CRC cis rs10771431 0.713 rs17794353 chr12:9361783 C/T cg08997352 chr12:9597637 DDX12 0.53 7.95 0.4 2.94e-14 Breast size; CRC cis rs72781680 1.000 rs72781632 chr2:24198342 A/C cg08917208 chr2:24149416 ATAD2B 1.04 10.15 0.49 2.97e-21 Lymphocyte counts; CRC cis rs8031584 0.678 rs798086 chr15:31129211 C/G cg08704250 chr15:31115839 NA 0.53 9.21 0.45 4.05e-18 Huntington's disease progression; CRC cis rs826838 1.000 rs11168367 chr12:38913397 T/G cg26384229 chr12:38710491 ALG10B 0.75 10.44 0.5 3.06e-22 Heart rate; CRC cis rs367943 1.000 rs168365 chr5:112817984 G/A cg12552261 chr5:112820674 MCC -0.49 -7.66 -0.39 2.06e-13 Type 2 diabetes; CRC cis rs7666738 0.830 rs114722517 chr4:99042061 G/A cg17366294 chr4:99064904 C4orf37 0.45 7.73 0.39 1.34e-13 Colonoscopy-negative controls vs population controls; CRC cis rs457287 0.772 rs17718266 chr9:4827541 T/C cg14182974 chr9:4791918 RCL1 -0.42 -5.77 -0.3 1.79e-8 Platelet count; CRC cis rs8180040 1.000 rs8180040 chr3:47388947 A/T cg10298567 chr3:47292165 KIF9 -0.44 -7.03 -0.36 1.19e-11 Colorectal cancer; CRC cis rs796364 0.951 rs11897245 chr2:201063644 A/G cg25936922 chr2:200820526 C2orf60;C2orf47 0.54 6.07 0.32 3.45e-9 Schizophrenia; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg03570976 chr16:66968476 FAM96B;CES2 0.43 6.25 0.33 1.25e-9 Intelligence (multi-trait analysis); CRC trans rs11098499 0.954 rs17005535 chr4:120411562 C/T cg25214090 chr10:38739885 LOC399744 0.65 10.56 0.5 1.25e-22 Corneal astigmatism; CRC cis rs977987 0.806 rs2285225 chr16:75429252 T/C cg03315344 chr16:75512273 CHST6 0.54 9.0 0.44 1.86e-17 Dupuytren's disease; CRC cis rs561341 0.556 rs542244 chr17:30307242 T/C cg00745463 chr17:30367425 LRRC37B -0.89 -9.87 -0.48 2.65e-20 Hip circumference adjusted for BMI; CRC cis rs2576037 0.623 rs2576042 chr18:44577461 T/C cg20875182 chr18:44561130 TCEB3B;KATNAL2 -0.61 -9.9 -0.48 2.07e-20 Personality dimensions; CRC cis rs6741819 1.000 rs6741819 chr2:7147973 A/G cg27144453 chr2:7172511 RNF144A 0.42 6.23 0.32 1.41e-9 Response to antipsychotic treatment; CRC cis rs832540 0.519 rs6895442 chr5:56260998 T/C cg24531977 chr5:56204891 C5orf35 -0.52 -8.35 -0.42 1.95e-15 Coronary artery disease; CRC trans rs7267979 0.932 rs449703 chr20:25458559 C/T cg17903999 chr18:56338584 MALT1 -0.41 -6.95 -0.36 1.98e-11 Liver enzyme levels (alkaline phosphatase); CRC trans rs11098499 1.000 rs28419773 chr4:120211061 T/C cg25214090 chr10:38739885 LOC399744 0.52 7.88 0.4 4.94e-14 Corneal astigmatism; CRC cis rs9291683 0.546 rs13120348 chr4:10053155 C/G cg00071950 chr4:10020882 SLC2A9 -0.64 -11.47 -0.53 7.77e-26 Bone mineral density; CRC cis rs738322 0.870 rs5750558 chr22:38582497 G/A cg17652424 chr22:38574118 PLA2G6 0.21 6.25 0.33 1.28e-9 Cutaneous nevi; CRC cis rs9322193 0.884 rs2064521 chr6:149946472 A/C cg13206674 chr6:150067644 NUP43 -0.64 -9.52 -0.46 4.01e-19 Lung cancer; CRC cis rs72772090 0.539 rs11135480 chr5:96110582 T/G cg17330273 chr5:96107758 CAST;ERAP1 -0.68 -6.02 -0.32 4.61e-9 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs7945705 0.818 rs2653613 chr11:8879105 C/T cg12365402 chr11:9010492 NRIP3 -0.51 -9.01 -0.44 1.76e-17 Hemoglobin concentration; CRC cis rs4664293 0.647 rs357022 chr2:160489444 A/G cg08347373 chr2:160653686 CD302 -0.39 -6.74 -0.35 7.15e-11 Monocyte percentage of white cells; CRC cis rs780096 0.526 rs75855890 chr2:27625005 G/T cg24768116 chr2:27665128 KRTCAP3 -0.35 -7.62 -0.39 2.68e-13 Total body bone mineral density; CRC cis rs7937682 0.924 rs12791699 chr11:111505880 T/C cg09085632 chr11:111637200 PPP2R1B -0.99 -19.28 -0.73 5.84e-56 Primary sclerosing cholangitis; CRC cis rs1475911 1.000 rs2839467 chr21:43513200 A/G cg14562523 chr21:43528734 C21orf128;UMODL1 0.48 6.49 0.34 3.15e-10 IgG glycosylation; CRC cis rs2243480 0.803 rs36127118 chr7:65565505 A/G cg12463550 chr7:65579703 CRCP 0.68 6.55 0.34 2.22e-10 Diabetic kidney disease; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg18222961 chr2:48009935 MSH6 0.39 6.23 0.32 1.4e-9 Liver disease severity in Alagille syndrome; CRC cis rs6499255 0.951 rs60472033 chr16:69677709 A/G cg15192750 chr16:69999425 NA 0.57 7.65 0.39 2.24e-13 IgE levels; CRC cis rs6500602 0.627 rs9934267 chr16:4534366 G/C cg06139259 chr16:4526053 HMOX2;NMRAL1 0.55 7.26 0.37 2.84e-12 Schizophrenia; CRC cis rs1799949 1.000 rs35956818 chr17:41422985 T/C cg23758822 chr17:41437982 NA 0.79 13.36 0.59 8e-33 Menopause (age at onset); CRC cis rs853679 0.517 rs9380057 chr6:28104634 G/T cg25164649 chr6:28176230 NA 0.76 9.53 0.46 3.71e-19 Depression; CRC cis rs13108904 0.870 rs13110563 chr4:1255772 G/C cg05665937 chr4:1216051 CTBP1 0.42 6.29 0.33 9.97e-10 Obesity-related traits; CRC cis rs2839186 0.732 rs8131458 chr21:47694712 G/A cg00815214 chr21:47717953 NA -0.33 -5.6 -0.3 4.49e-8 Testicular germ cell tumor; CRC cis rs4862750 0.832 rs6419953 chr4:187900509 T/A cg10295955 chr4:187884368 NA -1.06 -28.72 -0.85 1.21e-91 Lobe attachment (rater-scored or self-reported); CRC cis rs1971762 0.545 rs10876466 chr12:53981426 G/C cg06632207 chr12:54070931 ATP5G2 0.39 6.47 0.34 3.47e-10 Height; CRC cis rs55894533 0.597 rs2645408 chr8:11746358 A/G cg21281001 chr8:11725306 CTSB 0.42 5.91 0.31 8.76e-9 Leprosy; CRC cis rs2075371 0.863 rs2075370 chr7:133967812 A/G cg11752832 chr7:134001865 SLC35B4 0.43 6.63 0.34 1.37e-10 Mean platelet volume; CRC cis rs1878931 0.501 rs9635563 chr16:3416940 A/G cg26668626 chr16:3451006 ZNF174;ZNF434 0.69 9.41 0.46 9.17e-19 Body mass index (adult); CRC cis rs10484885 0.887 rs114928443 chr6:90602455 A/T cg13799429 chr6:90582589 CASP8AP2 -0.72 -8.41 -0.42 1.25e-15 QRS interval (sulfonylurea treatment interaction); CRC cis rs8141529 0.702 rs8137262 chr22:29292135 C/T cg15103426 chr22:29168792 CCDC117 0.48 6.58 0.34 1.87e-10 Lymphocyte counts; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg15051221 chr5:177434457 FAM153C -0.35 -6.22 -0.32 1.47e-9 Liver disease severity in Alagille syndrome; CRC cis rs728616 0.867 rs61860042 chr10:81946238 G/A cg05935833 chr10:81318306 SFTPA2 -0.72 -7.91 -0.4 3.91e-14 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs798554 0.797 rs798494 chr7:2798294 C/A cg19717773 chr7:2847554 GNA12 -0.47 -6.87 -0.35 3.15e-11 Height; CRC trans rs67073037 0.955 rs12611829 chr2:29144456 T/C cg13899017 chr1:159158444 CADM3 -0.36 -6.09 -0.32 3.16e-9 Breast cancer;Breast cancer (estrogen-receptor negative); CRC cis rs2062225 1.000 rs6733497 chr2:111773488 A/G cg11729679 chr2:111877065 BCL2L11 -0.56 -5.62 -0.3 4.08e-8 Monocyte count; CRC cis rs3812049 0.532 rs251389 chr5:127541877 A/C cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.67 8.23 0.41 4.37e-15 Lymphocyte counts;Red cell distribution width; CRC cis rs4400599 0.608 rs4845609 chr1:154181954 G/T cg26808167 chr1:154192205 UBAP2L;C1orf43 -0.37 -5.65 -0.3 3.48e-8 Platelet distribution width; CRC cis rs3806843 0.576 rs405192 chr5:140324710 T/G cg19875535 chr5:140030758 IK 0.39 6.0 0.31 5.23e-9 Depressive symptoms (multi-trait analysis); CRC trans rs1326986 0.702 rs7910815 chr10:19832047 C/G cg27614309 chr16:85478580 NA -0.46 -6.14 -0.32 2.37e-9 Ankylosing spondylitis; CRC cis rs854765 0.547 rs4368210 chr17:17896090 A/G cg23957660 chr17:17878224 LRRC48 -0.41 -7.15 -0.37 5.65e-12 Total body bone mineral density; CRC cis rs13144136 0.664 rs17267821 chr4:10653402 A/G cg10242279 chr4:10666415 CLNK -0.37 -6.32 -0.33 8.56e-10 Resistance to antihypertensive treatment in hypertension; CRC cis rs10883723 0.810 rs7079810 chr10:104243883 C/T cg22532475 chr10:104410764 TRIM8 -0.34 -6.07 -0.32 3.54e-9 Allergic disease (asthma, hay fever or eczema); CRC cis rs6502050 0.835 rs62078306 chr17:80085341 A/G cg09264619 chr17:80180166 NA 0.36 6.08 0.32 3.4e-9 Life satisfaction; CRC cis rs427941 0.632 rs201522 chr7:101771546 C/T cg06246474 chr7:101738831 CUX1 0.38 5.87 0.31 1.08e-8 Plasma omega-3 polyunsaturated fatty acid level (eicosapentaenoic acid); CRC trans rs2727020 0.553 rs3907576 chr11:49536639 A/C cg15704280 chr7:45808275 SEPT13 -0.95 -17.74 -0.7 7.17e-50 Coronary artery disease; CRC cis rs651907 0.535 rs36060163 chr3:101360963 C/T cg12386194 chr3:101231763 SENP7 0.48 6.9 0.36 2.68e-11 Colorectal cancer; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg25671651 chr2:203776787 ALS2CR8;WDR12 0.45 6.63 0.34 1.34e-10 Intelligence (multi-trait analysis); CRC cis rs1997103 0.911 rs6949931 chr7:55391081 T/C cg17469321 chr7:55412551 NA 0.73 11.32 0.53 2.67e-25 QRS interval (sulfonylurea treatment interaction); CRC cis rs9911578 0.842 rs12450766 chr17:56832965 G/C cg12560992 chr17:57184187 TRIM37 -0.88 -13.83 -0.61 1.3600000000000001e-34 Intelligence (multi-trait analysis); CRC cis rs8031584 0.678 rs36047941 chr15:31159235 A/G cg08109568 chr15:31115862 NA -0.68 -10.64 -0.51 6.3e-23 Huntington's disease progression; CRC trans rs7647973 0.626 rs4855833 chr3:49657441 A/G cg21665057 chr3:196295764 WDR53;FBXO45 -0.66 -7.44 -0.38 8.69e-13 Menarche (age at onset); CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg03894033 chr22:20850168 KLHL22 -0.42 -6.32 -0.33 8.72e-10 Myopia (pathological); CRC cis rs7811142 1.000 rs28490152 chr7:100020982 G/A cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.14 17.75 0.7 6.43e-50 Platelet count; CRC cis rs3091242 0.904 rs6661533 chr1:25771715 A/G cg20684491 chr1:25596433 NA 0.45 7.96 0.4 2.75e-14 Erythrocyte sedimentation rate; CRC cis rs5751901 0.929 rs2330805 chr22:24998619 A/G cg15363607 chr22:24998974 GGT1 -0.42 -6.72 -0.35 7.86e-11 Protein quantitative trait loci; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg13904018 chr4:1340886 KIAA1530 0.43 6.0 0.31 5.23e-9 Anxiety disorder; CRC cis rs2836974 0.602 rs8130854 chr21:40707041 G/A cg06238570 chr21:40685208 BRWD1 -0.79 -12.13 -0.56 3.16e-28 Cognitive function; CRC cis rs4974559 1.000 rs10006789 chr4:1330333 T/C cg02980000 chr4:1222292 CTBP1 0.54 6.86 0.35 3.46e-11 Systolic blood pressure; CRC cis rs6831352 0.840 rs35073321 chr4:100053276 G/A cg12011299 chr4:100065546 ADH4 -0.49 -9.27 -0.45 2.61e-18 Alcohol dependence; CRC cis rs919433 0.890 rs979020 chr2:198169749 T/C cg10820045 chr2:198174542 NA -0.55 -10.33 -0.49 7.58e-22 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC cis rs13315871 1.000 rs3196769 chr3:58409361 A/T cg20936604 chr3:58311152 NA -0.75 -7.12 -0.37 6.99e-12 Cholesterol, total; CRC trans rs2243480 1.000 rs2243480 chr7:65599196 C/T cg10756647 chr7:56101905 PSPH 0.67 7.06 0.36 9.88e-12 Diabetic kidney disease; CRC cis rs911555 0.655 rs10141157 chr14:104018105 T/C cg12935359 chr14:103987150 CKB -0.54 -9.61 -0.47 2.02e-19 Intelligence (multi-trait analysis); CRC cis rs11628318 0.853 rs4906226 chr14:103027359 C/T cg08075719 chr14:103021372 NA -0.69 -9.18 -0.45 4.94e-18 Platelet count; CRC cis rs9902453 0.726 rs3110494 chr17:27976597 A/G cg26525008 chr17:28256777 EFCAB5;SSH2 0.73 12.25 0.56 1.07e-28 Coffee consumption (cups per day); CRC cis rs11674184 0.743 rs12470971 chr2:11725241 A/G cg07314298 chr2:11723111 GREB1 0.65 11.68 0.54 1.34e-26 Endometriosis; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg08925066 chr14:39572669 SEC23A 0.39 6.55 0.34 2.23e-10 Liver disease severity in Alagille syndrome; CRC cis rs1008375 1.000 rs10805357 chr4:17652352 G/A cg16339924 chr4:17578868 LAP3 0.58 7.89 0.4 4.45e-14 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs4332037 0.539 rs868754 chr7:2033780 G/C cg24505167 chr7:1915268 MAD1L1 -0.47 -6.17 -0.32 2e-9 Bipolar disorder; CRC cis rs490234 0.702 rs35237975 chr9:128313867 A/G cg14078157 chr9:128172775 NA -0.4 -6.63 -0.34 1.34e-10 Mean arterial pressure; CRC cis rs6502050 0.835 rs4523985 chr17:80154466 C/A cg13198984 chr17:80129470 CCDC57 0.45 7.89 0.4 4.46e-14 Life satisfaction; CRC cis rs1552244 0.882 rs6796419 chr3:10040812 G/A cg16606324 chr3:10149918 C3orf24 0.6 8.18 0.41 6.05e-15 Alzheimer's disease; CRC cis rs12188164 0.525 rs2561665 chr5:460135 A/G cg21625146 chr5:486483 SLC9A3 0.37 5.69 0.3 2.86e-8 Cystic fibrosis severity; CRC cis rs7726839 0.540 rs7558 chr5:660491 C/T cg09021430 chr5:549028 NA -0.72 -8.16 -0.41 7.16e-15 Obesity-related traits; CRC cis rs7707921 0.958 rs4703870 chr5:81492643 G/A cg17942617 chr5:81327376 ATG10 -0.4 -6.02 -0.32 4.6e-9 Breast cancer; CRC cis rs2730245 0.645 rs4909282 chr7:158699797 T/C cg24397884 chr7:158709396 WDR60 0.73 10.46 0.5 2.7e-22 Height; CRC trans rs11148252 0.538 rs9535880 chr13:52706143 G/A cg18335740 chr13:41363409 SLC25A15 0.53 7.91 0.4 3.86e-14 Lewy body disease; CRC cis rs72829446 0.530 rs4796421 chr17:7379650 C/T cg07168214 chr17:7380112 ZBTB4 -0.4 -5.77 -0.3 1.82e-8 Androgen levels; CRC cis rs743757 0.878 rs12494849 chr3:50524558 C/G cg09545109 chr3:50388910 TUSC4;CYB561D2 0.44 6.13 0.32 2.45e-9 Diastolic blood pressure; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg09813219 chr15:38365138 NA 0.39 6.26 0.33 1.17e-9 Liver disease severity in Alagille syndrome; CRC cis rs6693567 0.565 rs696615 chr1:150338988 A/C cg15654264 chr1:150340011 RPRD2 0.43 6.48 0.34 3.27e-10 Migraine; CRC cis rs1448094 0.512 rs11503595 chr12:86244075 T/A cg02569458 chr12:86230093 RASSF9 0.42 7.24 0.37 3.17e-12 Major depressive disorder; CRC cis rs12540874 0.965 rs9791887 chr7:50661170 A/C cg18232548 chr7:50535776 DDC -0.43 -6.0 -0.31 5.35e-9 Systemic sclerosis; CRC cis rs1158570 0.500 rs2791342 chr8:131314429 C/T cg21674704 chr8:131455249 NA 0.39 5.94 0.31 7.15e-9 Platelet count; CRC cis rs754466 0.580 rs10824577 chr10:79577408 G/C cg17075019 chr10:79541650 NA -0.98 -19.23 -0.73 8.84e-56 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs829661 0.947 rs829665 chr2:30724701 T/A cg12454169 chr2:30669597 LCLAT1 1.02 9.71 0.47 9.35e-20 Midgestational circulating levels of PBDEs (fetal genetic effect); CRC cis rs769267 0.930 rs4808208 chr19:19650096 A/G cg01262667 chr19:19385393 TM6SF2 0.36 5.96 0.31 6.49e-9 Tonsillectomy; CRC cis rs12580194 0.593 rs58254871 chr12:55750281 G/A cg23425280 chr12:56401806 NA 0.46 5.65 0.3 3.39e-8 Cancer; CRC trans rs9329221 0.651 rs2975648 chr8:10135976 C/T cg06636001 chr8:8085503 FLJ10661 -0.64 -10.31 -0.49 8.47e-22 Neuroticism; CRC cis rs17209837 0.573 rs45537841 chr7:87110640 C/T cg00919237 chr7:87102261 ABCB4 -0.55 -7.24 -0.37 3.16e-12 Gallbladder cancer; CRC cis rs910316 0.967 rs12147532 chr14:75651858 T/G cg11812906 chr14:75593930 NEK9 -0.53 -7.93 -0.4 3.45e-14 Height; CRC trans rs959260 0.557 rs12936583 chr17:73304710 A/C cg12726277 chr7:973190 ADAP1 -0.4 -6.21 -0.32 1.61e-9 Systemic lupus erythematosus; CRC cis rs6866344 0.697 rs17184281 chr5:178127563 G/A cg03877680 chr5:178157825 ZNF354A 0.79 11.31 0.53 2.93e-25 Neutrophil percentage of white cells; CRC cis rs7264396 0.790 rs6060562 chr20:34282053 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.58 -9.44 -0.46 7.08e-19 Total cholesterol levels; CRC trans rs7615952 0.512 rs2979351 chr3:125363599 C/T cg07211511 chr3:129823064 LOC729375 -0.63 -8.69 -0.43 1.72e-16 Blood pressure (smoking interaction); CRC cis rs2239547 0.562 rs2581810 chr3:52960859 C/T cg15147215 chr3:52552868 STAB1 0.38 5.81 0.31 1.44e-8 Schizophrenia; CRC cis rs6754311 0.773 rs309178 chr2:136611624 C/T cg15123519 chr2:136567270 LCT 0.34 6.57 0.34 1.94e-10 Mosquito bite size; CRC cis rs6546550 0.868 rs12713682 chr2:70154134 G/A cg02498382 chr2:70120550 SNRNP27 -0.55 -9.39 -0.46 1.02e-18 Prevalent atrial fibrillation; CRC cis rs561341 0.883 rs2074102 chr17:30228884 G/A cg00745463 chr17:30367425 LRRC37B -0.74 -8.2 -0.41 5.41e-15 Hip circumference adjusted for BMI; CRC cis rs12479064 0.724 rs4851203 chr2:99986932 T/C cg26064155 chr2:99771622 LIPT1;TSGA10 -0.61 -7.53 -0.38 4.86e-13 Chronic sinus infection; CRC cis rs7712401 0.791 rs9327279 chr5:122122160 T/G cg18764291 chr5:122110994 SNX2 0.42 6.87 0.35 3.17e-11 Mean platelet volume; CRC cis rs10504229 0.679 rs11783963 chr8:58130496 T/A cg24829409 chr8:58192753 C8orf71 -0.55 -8.03 -0.4 1.71e-14 Developmental language disorder (linguistic errors); CRC cis rs875971 1.000 rs1968225 chr7:65874773 T/C cg12463550 chr7:65579703 CRCP 0.48 6.96 0.36 1.89e-11 Aortic root size; CRC cis rs9911578 1.000 rs7223955 chr17:56917053 C/A cg12560992 chr17:57184187 TRIM37 0.92 16.91 0.68 1.29e-46 Intelligence (multi-trait analysis); CRC cis rs6860806 0.603 rs112300250 chr5:131583292 G/A cg04518342 chr5:131593106 PDLIM4 0.45 8.39 0.42 1.4e-15 Breast cancer; CRC cis rs12586317 0.547 rs10134907 chr14:35499211 A/C cg16230307 chr14:35515116 FAM177A1 0.9 10.55 0.5 1.36e-22 Psoriasis; CRC cis rs11577318 0.853 rs4333841 chr1:26631927 T/C cg04990556 chr1:26633338 UBXN11 -0.48 -6.19 -0.32 1.74e-9 Granulocyte percentage of myeloid white cells; CRC cis rs6495122 0.644 rs11630087 chr15:75261673 G/T cg17294928 chr15:75287854 SCAMP5 0.49 7.1 0.36 7.66e-12 Caffeine consumption;Diastolic blood pressure;Coffee consumption; CRC cis rs1862618 0.671 rs2591956 chr5:56244604 G/A cg03609598 chr5:56110824 MAP3K1 0.59 7.96 0.4 2.85e-14 Initial pursuit acceleration; CRC cis rs801193 1.000 rs2659912 chr7:66157999 G/C cg11764359 chr7:65958608 NA 0.55 8.52 0.43 5.79e-16 Aortic root size; CRC cis rs6690583 1.000 rs2304641 chr1:85513398 C/T cg11262906 chr1:85462892 MCOLN2 0.54 6.65 0.34 1.19e-10 Serum sulfate level; CRC cis rs9287719 0.649 rs10198971 chr2:10718699 G/C cg00105475 chr2:10696890 NA 0.45 7.06 0.36 1.01e-11 Prostate cancer; CRC cis rs4654899 0.802 rs57351360 chr1:21229538 T/A cg02927042 chr1:21476669 EIF4G3 -0.5 -7.99 -0.4 2.36e-14 Superior frontal gyrus grey matter volume; CRC cis rs116095464 0.558 rs113796397 chr5:246503 A/G cg22857025 chr5:266934 NA -1.19 -15.3 -0.64 2.73e-40 Breast cancer; CRC cis rs7954584 0.567 rs1720033 chr12:122384344 C/T cg21171335 chr12:122356390 WDR66 -0.38 -5.83 -0.31 1.33e-8 Mean corpuscular volume; CRC cis rs736408 0.522 rs6445535 chr3:52771468 T/C cg05573699 chr3:52720067 GNL3;PBRM1 -0.47 -6.83 -0.35 3.99e-11 Bipolar disorder; CRC cis rs7843479 0.965 rs13269198 chr8:21823025 G/A cg17168535 chr8:21777572 XPO7 0.55 8.82 0.44 7.01e-17 Mean corpuscular volume; CRC cis rs6951245 0.572 rs73264028 chr7:1045455 G/A cg24642844 chr7:1081250 C7orf50 -0.74 -6.82 -0.35 4.31e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs7666738 0.830 rs10021709 chr4:99030587 G/A cg17366294 chr4:99064904 C4orf37 0.44 7.48 0.38 6.96e-13 Colonoscopy-negative controls vs population controls; CRC cis rs6933660 0.720 rs6913515 chr6:151753470 G/C cg10883421 chr6:151773342 RMND1;C6orf211 0.69 11.59 0.54 2.85e-26 Menarche (age at onset); CRC cis rs9914988 0.943 rs7215310 chr17:27088626 G/T cg07195577 chr17:27052828 TLCD1 0.38 5.65 0.3 3.53e-8 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs6502050 0.835 rs8066284 chr17:80127825 C/T cg25804541 chr17:80189381 SLC16A3 -0.3 -5.84 -0.31 1.23e-8 Life satisfaction; CRC trans rs12887734 0.546 rs66676135 chr14:104271504 G/A cg06206626 chr22:26825900 ASPHD2 0.41 5.98 0.31 5.82e-9 Schizophrenia;Autism spectrum disorder or schizophrenia; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg25355226 chr3:150320980 SELT 0.56 8.24 0.41 4.01e-15 Response to antipsychotic treatment; CRC cis rs8177179 0.503 rs9985395 chr3:133413119 A/G cg24879335 chr3:133465180 TF -0.32 -6.02 -0.31 4.72e-9 Iron status biomarkers (transferrin levels); CRC cis rs1218582 0.772 rs10908448 chr1:154882544 A/G cg09359103 chr1:154839909 KCNN3 0.71 12.72 0.57 2.06e-30 Prostate cancer; CRC cis rs908922 0.676 rs6658925 chr1:152482801 C/T cg23254163 chr1:152506842 NA -0.4 -8.05 -0.41 1.57e-14 Hair morphology; CRC cis rs2882667 0.824 rs13189485 chr5:138475401 C/T cg09476006 chr5:138032270 NA 0.42 6.32 0.33 8.53e-10 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs68170813 0.559 rs7794965 chr7:106826439 A/G cg02696742 chr7:106810147 HBP1 0.59 6.76 0.35 6.28e-11 Coronary artery disease; CRC cis rs875971 1.000 rs6961990 chr7:65888570 C/A cg12463550 chr7:65579703 CRCP 0.5 7.14 0.37 6.16e-12 Aortic root size; CRC cis rs60871478 1.000 rs62432252 chr7:802886 C/G cg05535760 chr7:792225 HEATR2 0.81 10.57 0.5 1.1e-22 Cerebrospinal P-tau181p levels; CRC cis rs6540559 0.605 rs3753518 chr1:209977964 G/C cg21951975 chr1:209979733 IRF6 0.49 6.64 0.34 1.3100000000000001e-10 Cleft lip with or without cleft palate; CRC cis rs13082711 0.911 rs13082777 chr3:27421942 A/G cg02860705 chr3:27208620 NA 0.6 8.71 0.43 1.5e-16 Systolic blood pressure;Diastolic blood pressure;Blood pressure; CRC trans rs9291683 0.595 rs35501905 chr4:10053431 C/T cg26043149 chr18:55253948 FECH 0.55 8.65 0.43 2.37e-16 Bone mineral density; CRC cis rs9733 0.596 rs11586422 chr1:150679358 C/T cg17724175 chr1:150552817 MCL1 0.57 9.12 0.45 7.76e-18 Tonsillectomy; CRC cis rs526821 0.553 rs295597 chr11:55470003 T/C cg04317927 chr11:55418816 OR4S2 0.41 6.77 0.35 6.09e-11 Pediatric bone mineral density (spine); CRC cis rs58804349 0.685 rs9422671 chr10:43288626 T/G cg20628663 chr10:43360327 NA 0.72 7.32 0.37 1.93e-12 Pediatric bone mineral content (radius); CRC cis rs425277 0.500 rs908744 chr1:2038893 G/A cg03732007 chr1:2071316 PRKCZ -0.36 -5.69 -0.3 2.77e-8 Height; CRC cis rs2032447 0.670 rs198815 chr6:26127271 A/G cg26028573 chr6:26043587 HIST1H2BB -0.39 -5.65 -0.3 3.45e-8 Intelligence (multi-trait analysis); CRC cis rs2760061 0.569 rs621631 chr1:228114728 A/G cg02753203 chr1:228287806 NA -0.59 -8.72 -0.43 1.43e-16 Diastolic blood pressure; CRC cis rs9928842 0.823 rs2870472 chr16:75278841 C/G cg09066997 chr16:75300724 BCAR1 0.69 6.8 0.35 4.96e-11 Alcoholic chronic pancreatitis; CRC cis rs9322193 0.923 rs62441284 chr6:150072678 C/A cg05861140 chr6:150128134 PCMT1 -0.39 -6.39 -0.33 5.67e-10 Lung cancer; CRC cis rs9488822 0.676 rs7774952 chr6:116380909 A/G cg18764771 chr6:116381957 FRK 0.24 6.96 0.36 1.81e-11 Cholesterol, total;LDL cholesterol; CRC cis rs11958404 0.932 rs72816556 chr5:157424412 C/G cg05962755 chr5:157440814 NA 0.79 10.82 0.51 1.57e-23 IgG glycosylation; CRC cis rs6121246 0.567 rs6058197 chr20:30194899 A/G cg18721089 chr20:30220636 NA -0.52 -7.93 -0.4 3.54e-14 Mean corpuscular hemoglobin; CRC cis rs7212590 1.000 rs73315284 chr17:57884868 A/G cg10252138 chr17:58120427 NA -0.54 -5.73 -0.3 2.32e-8 Granulocyte percentage of myeloid white cells;Monocyte count;Monocyte percentage of white cells; CRC cis rs34375054 0.738 rs10773145 chr12:125625603 C/T cg25124228 chr12:125621409 AACS 0.63 10.45 0.5 2.8e-22 Post bronchodilator FEV1/FVC ratio; CRC cis rs6495122 0.501 rs6495151 chr15:75385990 A/G cg14664628 chr15:75095509 CSK 0.41 6.0 0.31 5.14e-9 Caffeine consumption;Diastolic blood pressure;Coffee consumption; CRC cis rs3126085 0.877 rs4845742 chr1:152183949 G/A cg09127314 chr1:152161683 NA 0.52 6.62 0.34 1.5e-10 Atopic dermatitis; CRC cis rs35883536 0.967 rs2783689 chr1:101092411 C/G cg14515779 chr1:101123966 NA 0.38 6.91 0.36 2.57e-11 Monocyte count; CRC cis rs1552244 1.000 rs6781811 chr3:10121922 A/G cg10729496 chr3:10149963 C3orf24 -0.51 -6.81 -0.35 4.73e-11 Alzheimer's disease; CRC cis rs7814319 0.674 rs7836698 chr8:97242849 C/T cg20787634 chr8:97240163 UQCRB -0.45 -7.32 -0.37 1.87e-12 Lung function (FVC); CRC cis rs11696845 0.649 rs6031782 chr20:43383832 A/G cg25301532 chr20:43378953 KCNK15 -0.38 -6.42 -0.33 4.66e-10 Obesity-related traits; CRC cis rs10256972 0.616 rs4998392 chr7:1113344 A/C cg04025307 chr7:1156635 C7orf50 0.57 8.76 0.43 1.05e-16 Longevity;Endometriosis; CRC cis rs72781680 0.716 rs2712086 chr2:24004739 G/C cg08917208 chr2:24149416 ATAD2B 0.54 6.41 0.33 5.11e-10 Lymphocyte counts; CRC cis rs17401966 0.838 rs1013952 chr1:10319247 G/A cg19773385 chr1:10388646 KIF1B -0.68 -11.19 -0.52 7.82e-25 Hepatocellular carcinoma; CRC cis rs3820068 0.603 rs6660234 chr1:15962590 T/C cg24675056 chr1:15929824 NA 0.5 6.81 0.35 4.53e-11 Systolic blood pressure; CRC cis rs477895 0.653 rs2015226 chr11:63902534 C/T cg04317338 chr11:64019027 PLCB3 0.6 7.28 0.37 2.53e-12 Mean platelet volume; CRC cis rs9287719 0.901 rs10210859 chr2:10733929 C/T cg00105475 chr2:10696890 NA 0.45 7.26 0.37 2.75e-12 Prostate cancer; CRC cis rs10484885 0.877 rs17735389 chr6:90323139 G/T cg13799429 chr6:90582589 CASP8AP2 -0.74 -7.75 -0.39 1.17e-13 QRS interval (sulfonylurea treatment interaction); CRC cis rs9611565 0.559 rs5758412 chr22:42080803 T/A cg03806693 chr22:41940476 POLR3H 1.05 13.07 0.58 1.02e-31 Vitiligo; CRC cis rs546131 0.928 rs499183 chr11:34836678 A/G cg24088639 chr11:34937564 PDHX;APIP -0.42 -5.94 -0.31 7.16e-9 Lung disease severity in cystic fibrosis; CRC cis rs3749237 0.595 rs17595772 chr3:49409704 G/A cg07636037 chr3:49044803 WDR6 0.55 8.1 0.41 1.08e-14 Resting heart rate; CRC trans rs1005277 0.579 rs2749612 chr10:38488610 G/A cg27523141 chr10:43048294 ZNF37B 0.47 6.88 0.35 3.11e-11 Extrinsic epigenetic age acceleration; CRC cis rs870825 0.698 rs2696046 chr4:185599972 G/A cg07424746 chr4:185654737 MLF1IP 0.56 5.65 0.3 3.49e-8 Blood protein levels; CRC cis rs6662572 0.737 rs6673894 chr1:46301182 G/A cg03123370 chr1:45965343 CCDC163P;MMACHC -0.48 -6.09 -0.32 3.11e-9 Blood protein levels; CRC cis rs4588572 0.570 rs6453389 chr5:77727003 T/G cg11547950 chr5:77652471 NA -0.5 -7.19 -0.37 4.46e-12 Triglycerides; CRC cis rs1153858 1.000 rs67831559 chr15:45649307 G/T cg21132104 chr15:45694354 SPATA5L1 0.58 8.52 0.42 6.03e-16 Homoarginine levels; CRC cis rs877282 0.891 rs34652870 chr10:772218 T/C cg17470449 chr10:769945 NA 0.63 8.43 0.42 1.11e-15 Uric acid levels; CRC cis rs11625487 0.609 rs78371022 chr14:77971029 G/A cg20045696 chr14:77926864 AHSA1 -0.72 -6.15 -0.32 2.26e-9 Neutrophil percentage of white cells;Sum neutrophil eosinophil counts;Neutrophil count; CRC cis rs75804782 0.641 rs56000747 chr2:239318541 T/G cg18131467 chr2:239335373 ASB1 -0.7 -6.06 -0.32 3.7e-9 Morning vs. evening chronotype;Chronotype; CRC cis rs763121 0.853 rs6001204 chr22:39100239 T/C cg06544989 chr22:39130855 UNC84B 0.48 7.65 0.39 2.25e-13 Menopause (age at onset); CRC trans rs2303319 0.582 rs72870248 chr2:162435849 G/A cg09481857 chr22:21368659 P2RX6;MGC16703 -0.65 -6.02 -0.31 4.57e-9 Cognitive function; CRC cis rs6952808 0.717 rs6967442 chr7:1926090 A/G cg00106254 chr7:1943704 MAD1L1 -0.43 -6.89 -0.36 2.81e-11 Bipolar disorder and schizophrenia; CRC cis rs1950626 0.577 rs61991118 chr14:101441974 C/T cg02351406 chr14:101447389 SNORD114-20;SNORD114-21 0.75 12.12 0.56 3.4e-28 Pelvic organ prolapse (moderate/severe); CRC cis rs2760061 0.583 rs3094911 chr1:228210179 A/G cg02753203 chr1:228287806 NA 0.91 14.41 0.62 7.47e-37 Diastolic blood pressure; CRC cis rs4237845 0.611 rs4373979 chr12:58332386 C/G cg02175503 chr12:58329896 NA 0.79 12.42 0.56 2.73e-29 Intelligence (multi-trait analysis); CRC cis rs7666738 0.791 rs1405766 chr4:98965389 T/C cg17366294 chr4:99064904 C4orf37 0.43 7.36 0.38 1.49e-12 Colonoscopy-negative controls vs population controls; CRC cis rs561341 1.000 rs550264 chr17:30317540 G/T cg23018236 chr17:30244563 NA -0.67 -8.03 -0.4 1.78e-14 Hip circumference adjusted for BMI; CRC cis rs7552404 0.924 rs1146580 chr1:76209935 T/C cg22875332 chr1:76189707 ACADM 0.69 10.52 0.5 1.66e-22 Blood metabolite levels;Acylcarnitine levels; CRC cis rs17401966 1.000 rs12734068 chr1:10376803 G/A cg19773385 chr1:10388646 KIF1B -0.59 -8.05 -0.41 1.54e-14 Hepatocellular carcinoma; CRC cis rs8031584 0.678 rs4779496 chr15:31151054 A/G cg08109568 chr15:31115862 NA -0.68 -10.62 -0.51 7.54e-23 Huntington's disease progression; CRC cis rs6543140 0.929 rs11465700 chr2:103057668 G/A cg04239558 chr2:103089729 SLC9A4 0.35 6.07 0.32 3.58e-9 Blood protein levels; CRC cis rs11122272 0.766 rs2486732 chr1:231531476 A/C cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.59 -9.0 -0.44 1.81e-17 Hemoglobin concentration; CRC cis rs1799949 0.965 rs4793204 chr17:41279298 A/G cg05368731 chr17:41323189 NBR1 0.69 10.48 0.5 2.22e-22 Menopause (age at onset); CRC cis rs6942756 1.000 rs10954226 chr7:128953095 T/G cg02491457 chr7:128862824 NA -0.74 -10.07 -0.49 5.92e-21 White matter hyperintensity burden; CRC cis rs1124376 0.810 rs6807771 chr3:20160634 C/A cg05072819 chr3:20081367 KAT2B 0.5 6.03 0.32 4.46e-9 Bipolar disorder and schizophrenia; CRC cis rs853679 0.517 rs36078605 chr6:28078032 A/C cg03623178 chr6:28175578 NA 0.94 11.9 0.55 2.08e-27 Depression; CRC cis rs4566357 0.615 rs4675139 chr2:227908527 G/A cg11843606 chr2:227700838 RHBDD1 -0.44 -6.79 -0.35 5.09e-11 Coronary artery disease; CRC cis rs8072100 0.967 rs8075411 chr17:45676760 C/T cg25173405 chr17:45401733 C17orf57 0.42 6.51 0.34 2.84e-10 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs9916302 0.660 rs4795379 chr17:37674683 T/G cg07936489 chr17:37558343 FBXL20 -0.92 -11.86 -0.55 2.95e-27 Glomerular filtration rate (creatinine); CRC trans rs561341 0.941 rs2428338 chr17:30299629 T/C cg27661571 chr11:113659931 NA -0.71 -8.89 -0.44 4.22e-17 Hip circumference adjusted for BMI; CRC cis rs9902453 0.904 rs55866125 chr17:28312993 T/C cg26525008 chr17:28256777 EFCAB5;SSH2 0.74 12.25 0.56 1.09e-28 Coffee consumption (cups per day); CRC cis rs904251 0.620 rs883372 chr6:37477605 A/C cg01843034 chr6:37503916 NA -0.4 -5.78 -0.3 1.77e-8 Cognitive performance; CRC cis rs3764563 1.000 rs4646530 chr19:15735238 A/T cg20725493 chr19:15740067 CYP4F8 0.72 7.34 0.38 1.71e-12 Inflammatory biomarkers; CRC cis rs17234274 0.644 rs10833973 chr11:23220064 A/T cg05245346 chr11:23248277 NA 0.35 5.75 0.3 2.03e-8 Cancer; CRC cis rs1215050 0.791 rs1215054 chr4:98863009 T/G cg05340658 chr4:99064831 C4orf37 -0.49 -7.46 -0.38 7.7e-13 Waist-to-hip ratio adjusted for body mass index; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg16714605 chr19:10765132 ILF3;LOC147727 0.39 6.81 0.35 4.55e-11 Liver disease severity in Alagille syndrome; CRC cis rs853679 0.517 rs9393891 chr6:28079160 C/T cg02683197 chr6:28174875 NA 0.85 10.27 0.49 1.16e-21 Depression; CRC cis rs2153535 0.541 rs9328477 chr6:8519109 T/C cg21535247 chr6:8435926 SLC35B3 0.48 7.36 0.38 1.51e-12 Motion sickness; CRC cis rs1552244 0.882 rs9757159 chr3:10039166 C/T cg18598329 chr3:10140678 FANCD2;C3orf24 -0.81 -10.69 -0.51 4.35e-23 Alzheimer's disease; CRC cis rs9287719 0.649 rs10182589 chr2:10720664 C/T cg00105475 chr2:10696890 NA 0.45 7.06 0.36 9.97e-12 Prostate cancer; CRC cis rs12824058 0.831 rs12297939 chr12:130811923 G/C cg26677194 chr12:130822605 PIWIL1 0.45 7.18 0.37 4.53e-12 Menopause (age at onset); CRC cis rs9733 0.596 rs6686525 chr1:150635811 C/T cg15448220 chr1:150897856 SETDB1 0.45 6.46 0.34 3.88e-10 Tonsillectomy; CRC cis rs9911578 0.933 rs2632508 chr17:56533235 G/A cg05425664 chr17:57184151 TRIM37 -0.52 -8.23 -0.41 4.46e-15 Intelligence (multi-trait analysis); CRC cis rs728616 0.764 rs79529820 chr10:81820529 A/T cg05935833 chr10:81318306 SFTPA2 -0.55 -6.81 -0.35 4.73e-11 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs1046896 0.552 rs12602280 chr17:80805421 G/C cg19500275 chr17:80737654 TBCD 0.49 6.47 0.34 3.55e-10 Glycated hemoglobin levels; CRC cis rs11599315 0.507 rs12220554 chr10:1341852 C/T cg09624528 chr10:1369823 ADARB2 0.4 5.94 0.31 7.16e-9 Thiazide-induced adverse metabolic effects in hypertensive patients; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg12430567 chr5:159848786 PTTG1 0.43 6.13 0.32 2.48e-9 Intelligence (multi-trait analysis); CRC cis rs4713118 0.869 rs9461405 chr6:27719375 G/T cg26587870 chr6:27730563 NA -0.43 -6.77 -0.35 6.04e-11 Parkinson's disease; CRC cis rs13108904 0.870 rs13110563 chr4:1255772 G/C cg19318889 chr4:1322082 MAEA 0.41 5.98 0.31 5.74e-9 Obesity-related traits; CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg21956150 chr19:1438388 RPS15 0.42 6.74 0.35 6.92e-11 Obesity-related traits; CRC cis rs2976388 0.647 rs2585154 chr8:143783485 C/T cg12516270 chr8:143859308 LYNX1 0.4 6.93 0.36 2.24e-11 Urinary tract infection frequency; CRC cis rs875971 0.545 rs2707851 chr7:66089165 C/T cg18876405 chr7:65276391 NA -0.45 -6.24 -0.33 1.35e-9 Aortic root size; CRC cis rs7618501 0.633 rs9866695 chr3:50069452 G/T cg24308560 chr3:49941425 MST1R 0.52 8.44 0.42 1e-15 Intelligence (multi-trait analysis); CRC cis rs853679 0.599 rs156743 chr6:27967089 T/C cg15786705 chr6:28176104 NA 0.67 6.41 0.33 5.07e-10 Depression; CRC cis rs9303280 0.901 rs1008723 chr17:38066267 G/T cg11212589 chr17:38028394 ZPBP2 0.42 7.64 0.39 2.4e-13 Self-reported allergy; CRC cis rs10193935 1.000 rs10185742 chr2:42429666 A/G cg27598129 chr2:42591480 NA -0.73 -8.35 -0.42 1.94e-15 Colonoscopy-negative controls vs population controls; CRC cis rs2243480 1.000 rs316329 chr7:65608416 A/C cg25985355 chr7:65971099 NA -0.52 -6.17 -0.32 2e-9 Diabetic kidney disease; CRC cis rs9796 0.870 rs2925342 chr15:41305733 A/G cg18705301 chr15:41695430 NDUFAF1 0.34 5.74 0.3 2.19e-8 Menopause (age at onset); CRC cis rs6500602 0.727 rs4786516 chr16:4578641 C/T cg14951292 chr16:4525986 HMOX2;NMRAL1 0.58 8.79 0.44 8.46e-17 Schizophrenia; CRC cis rs4474465 0.850 rs7936232 chr11:78266602 A/G cg02023728 chr11:77925099 USP35 -0.36 -6.14 -0.32 2.41e-9 Alzheimer's disease (survival time); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg11071762 chr1:111746640 NA 0.46 6.43 0.33 4.46e-10 Response to antipsychotic treatment; CRC trans rs35847492 1.000 rs35847492 chr8:9276025 G/C cg06636001 chr8:8085503 FLJ10661 0.44 6.17 0.32 2.02e-9 Neuroticism; CRC cis rs4689388 0.727 rs1801213 chr4:6293696 C/G cg14416269 chr4:6271139 WFS1 0.41 6.54 0.34 2.3e-10 Type 2 diabetes and other traits;Type 2 diabetes; CRC cis rs7584330 0.518 rs11884238 chr2:238424671 T/G cg14458575 chr2:238380390 NA 0.43 6.22 0.32 1.51e-9 Prostate cancer; CRC cis rs7918232 0.830 rs7911024 chr10:27433636 A/C cg14442939 chr10:27389572 ANKRD26 0.82 9.16 0.45 5.68e-18 Breast cancer; CRC cis rs611744 0.647 rs2594358 chr8:109256018 A/G cg18478394 chr8:109455254 TTC35 0.38 5.73 0.3 2.33e-8 Dupuytren's disease; CRC cis rs7208859 0.673 rs73265612 chr17:29225983 A/G cg13385521 chr17:29058706 SUZ12P 0.69 7.93 0.4 3.48e-14 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs71403859 0.803 rs10500562 chr16:71627731 A/C cg08717414 chr16:71523259 ZNF19 -1.14 -10.98 -0.52 4.1e-24 Post bronchodilator FEV1; CRC cis rs2019137 0.560 rs4849179 chr2:113985170 C/T cg25243455 chr2:114033360 PAX8;LOC440839 -0.28 -6.86 -0.35 3.36e-11 Lymphocyte counts; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg16211055 chr1:228594250 TRIM11 0.5 7.14 0.37 5.91e-12 Response to antipsychotic treatment; CRC cis rs3540 0.960 rs8030722 chr15:90974920 G/A cg22089800 chr15:90895588 ZNF774 0.49 7.8 0.4 8.01e-14 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; CRC cis rs11608355 0.515 rs11611011 chr12:109936948 C/T cg05360138 chr12:110035743 NA 0.77 8.64 0.43 2.48e-16 Neuroticism; CRC cis rs7584330 0.554 rs76408976 chr2:238384784 C/T cg08992911 chr2:238395768 MLPH 0.63 6.13 0.32 2.45e-9 Prostate cancer; CRC cis rs67311347 0.824 rs59922539 chr3:40337110 G/A cg09455208 chr3:40491958 NA 0.36 7.0 0.36 1.42e-11 Renal cell carcinoma; CRC cis rs921968 0.565 rs6704575 chr2:219589594 C/T cg02176678 chr2:219576539 TTLL4 0.39 6.21 0.32 1.63e-9 Mean corpuscular hemoglobin concentration; CRC trans rs66573146 0.831 rs67602077 chr4:7024244 A/G cg07817883 chr1:32538562 TMEM39B 1.27 10.57 0.5 1.09e-22 Granulocyte percentage of myeloid white cells; CRC cis rs9322193 0.923 rs4870529 chr6:150037572 A/G cg05861140 chr6:150128134 PCMT1 -0.37 -5.96 -0.31 6.32e-9 Lung cancer; CRC cis rs2180341 1.000 rs9385419 chr6:127597591 A/G cg27446573 chr6:127587934 RNF146 0.99 14.76 0.63 3.48e-38 Breast cancer; CRC cis rs2252521 0.614 rs317703 chr7:29087226 G/C cg11728747 chr7:29037910 CPVL -0.47 -6.68 -0.35 1.02e-10 Cognitive performance; CRC cis rs875971 0.545 rs10950029 chr7:65634321 A/C cg18876405 chr7:65276391 NA 0.44 6.22 0.32 1.49e-9 Aortic root size; CRC cis rs6461049 0.638 rs3778994 chr7:2175855 G/T cg02951883 chr7:2050386 MAD1L1 -0.48 -7.68 -0.39 1.83e-13 Schizophrenia; CRC cis rs853679 0.517 rs4711164 chr6:28115156 C/T cg12273811 chr6:28175739 NA 0.73 9.16 0.45 5.8e-18 Depression; CRC cis rs6500395 1.000 rs9922734 chr16:48603192 A/G cg04672837 chr16:48644449 N4BP1 -0.45 -6.68 -0.35 1.01e-10 Response to tocilizumab in rheumatoid arthritis; CRC cis rs1552244 0.808 rs7615088 chr3:10035896 A/T cg10729496 chr3:10149963 C3orf24 0.49 6.34 0.33 7.69e-10 Alzheimer's disease; CRC cis rs9611565 0.802 rs132916 chr22:41806768 C/G cg03806693 chr22:41940476 POLR3H 0.88 11.35 0.53 2.1e-25 Vitiligo; CRC cis rs2302190 0.882 rs12939703 chr17:56611090 G/C cg12560992 chr17:57184187 TRIM37 0.5 5.89 0.31 9.67e-9 Vitamin D levels; CRC cis rs6534441 0.727 rs7675285 chr4:125422463 G/A cg21609808 chr4:125404261 NA 0.46 6.45 0.34 3.97e-10 Major depressive disorder; CRC cis rs972578 0.837 rs1018448 chr22:43206950 A/C cg01576275 chr22:43409880 NA -0.4 -6.29 -0.33 1.03e-9 Mean platelet volume; CRC trans rs10982213 0.830 rs2274163 chr9:117188714 C/T cg15216925 chr5:179921655 CNOT6 0.45 7.46 0.38 7.73e-13 Interleukin-6 levels; CRC cis rs7677751 0.806 rs1800810 chr4:55094031 C/G cg17187183 chr4:55093834 PDGFRA 0.52 7.71 0.39 1.49e-13 Corneal astigmatism; CRC cis rs2239547 0.657 rs2071040 chr3:52864860 A/G cg15147215 chr3:52552868 STAB1 -0.48 -6.52 -0.34 2.59e-10 Schizophrenia; CRC cis rs910316 0.763 rs2080201 chr14:75629972 C/T cg03030879 chr14:75389066 RPS6KL1 0.39 5.94 0.31 7.3e-9 Height; CRC cis rs763014 0.966 rs7185390 chr16:666382 A/G cg04497992 chr16:616212 NHLRC4 0.42 6.68 0.35 9.92e-11 Height; CRC cis rs1018836 0.544 rs10112371 chr8:91457626 C/T cg16814680 chr8:91681699 NA 0.45 6.79 0.35 5.18e-11 Ejection fraction in Tripanosoma cruzi seropositivity; CRC cis rs10089 1.000 rs4836368 chr5:127486330 T/A cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.72 10.07 0.49 5.69e-21 Ileal carcinoids; CRC cis rs7208859 0.725 rs9897673 chr17:29243366 T/C cg01831904 chr17:28903510 LRRC37B2 -0.48 -6.0 -0.31 5.3e-9 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs7527798 0.592 rs2296159 chr1:207851760 G/A cg09232269 chr1:207846808 CR1L -0.48 -7.78 -0.39 9.29e-14 Erythrocyte sedimentation rate; CRC cis rs57994353 0.897 rs11999532 chr9:139371405 G/C cg13611204 chr9:139324423 INPP5E -0.41 -5.7 -0.3 2.63e-8 Eosinophil counts;Cutaneous squamous cell carcinoma; CRC cis rs8067354 0.645 rs2645486 chr17:57885901 T/A cg13753209 chr17:57696993 CLTC 0.45 5.88 0.31 9.94e-9 Hemoglobin concentration; CRC cis rs870825 0.616 rs35818632 chr4:185649661 G/T cg04058563 chr4:185651563 MLF1IP 0.71 8.01 0.4 2.05e-14 Blood protein levels; CRC cis rs2949837 0.581 rs2965072 chr7:45980751 G/T cg21268650 chr7:45961089 IGFBP3 0.38 6.5 0.34 2.92e-10 Sitting height ratio; CRC cis rs10256972 0.786 rs3735686 chr7:1062527 G/A cg18402987 chr7:1209562 NA 0.4 5.83 0.31 1.29e-8 Longevity;Endometriosis; CRC trans rs925098 0.577 rs2724470 chr4:17996046 A/G cg11284414 chr2:232573146 PTMA -0.41 -6.11 -0.32 2.77e-9 Birth weight;Height; CRC cis rs7618501 0.602 rs2245365 chr3:50097319 C/A cg24110177 chr3:50126178 RBM5 0.48 7.24 0.37 3.13e-12 Intelligence (multi-trait analysis); CRC cis rs2929278 0.617 rs4617832 chr15:44030579 G/A cg02155558 chr15:43621948 ADAL;LCMT2 -0.46 -6.37 -0.33 6.31e-10 Schizophrenia; CRC cis rs4474465 1.000 rs10899533 chr11:78208480 T/C cg27205649 chr11:78285834 NARS2 0.46 5.69 0.3 2.75e-8 Alzheimer's disease (survival time); CRC cis rs4285028 1.000 rs4285028 chr3:121660664 A/C cg11130432 chr3:121712080 ILDR1 -0.43 -5.66 -0.3 3.32e-8 Multiple sclerosis; CRC trans rs7395662 0.571 rs12421145 chr11:48624725 C/A cg21153622 chr11:89784906 NA -0.52 -8.68 -0.43 1.92e-16 HDL cholesterol; CRC cis rs651907 0.535 rs13065944 chr3:101473088 G/A cg12386194 chr3:101231763 SENP7 0.5 7.37 0.38 1.42e-12 Colorectal cancer; CRC cis rs738321 0.757 rs2284062 chr22:38544221 A/G cg25457927 chr22:38595422 NA -0.31 -6.05 -0.32 3.86e-9 Breast cancer; CRC cis rs11677416 0.961 rs3783557 chr2:113530712 C/T cg27083787 chr2:113543245 IL1A 0.6 7.79 0.39 9.1e-14 Response to antipsychotic treatment in schizophrenia (working memory); CRC cis rs10504229 0.728 rs1495867 chr8:58155500 G/T cg02290350 chr8:58132656 NA -0.51 -6.57 -0.34 1.98e-10 Developmental language disorder (linguistic errors); CRC cis rs950776 0.642 rs7178007 chr15:78965254 G/A cg06917634 chr15:78832804 PSMA4 0.45 6.6 0.34 1.63e-10 Sudden cardiac arrest; CRC cis rs4666002 0.636 rs13023194 chr2:27967260 G/C cg27432699 chr2:27873401 GPN1 0.54 6.19 0.32 1.8e-9 Phospholipid levels (plasma); CRC cis rs3858526 0.676 rs10838752 chr11:5887243 A/G cg05234568 chr11:5960015 NA -0.55 -7.49 -0.38 6.41e-13 DNA methylation (variation); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg15839751 chr8:146126984 ZNF250 0.42 6.29 0.33 9.88e-10 Intelligence (multi-trait analysis); CRC cis rs12760731 0.565 rs12034657 chr1:178099354 A/C cg00404053 chr1:178313656 RASAL2 -0.99 -10.21 -0.49 1.97e-21 Obesity-related traits; CRC cis rs9942416 0.660 rs111937612 chr5:74979631 C/T cg19683494 chr5:74908142 NA 0.49 6.26 0.33 1.23e-9 Age-related disease endophenotypes; CRC cis rs17155006 0.746 rs425623 chr7:107747465 C/T cg05962710 chr7:107745446 LAMB4 -0.41 -7.44 -0.38 8.61e-13 Pneumococcal bacteremia; CRC cis rs2976388 0.590 rs4736322 chr8:143822208 T/C cg24046110 chr8:143859143 LYNX1 -0.43 -6.9 -0.36 2.67e-11 Urinary tract infection frequency; CRC cis rs17376456 0.825 rs17314797 chr5:93234845 T/A cg09848695 chr5:92956644 FAM172A;MIR2277 0.66 5.98 0.31 5.9e-9 Diabetic retinopathy; CRC cis rs10197940 0.638 rs2288193 chr2:152348842 T/A cg19508488 chr2:152266495 RIF1 0.58 7.91 0.4 4.06e-14 Lung cancer; CRC trans rs728616 0.681 rs36023925 chr10:81906846 T/C cg18543242 chr14:23290393 SLC7A7 0.45 6.08 0.32 3.29e-9 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs7412746 0.611 rs11204726 chr1:150743492 T/C cg15448220 chr1:150897856 SETDB1 0.51 7.19 0.37 4.25e-12 Melanoma; CRC cis rs4713118 0.662 rs9468276 chr6:28027688 A/C cg23161317 chr6:28129485 ZNF389 0.44 5.76 0.3 1.96e-8 Parkinson's disease; CRC cis rs2836974 1.000 rs28360661 chr21:40681972 G/C cg06238570 chr21:40685208 BRWD1 0.76 10.24 0.49 1.53e-21 Cognitive function; CRC trans rs1814175 0.712 rs9665784 chr11:50030617 C/T cg15704280 chr7:45808275 SEPT13 -1.0 -20.79 -0.75 6.66e-62 Height; CRC cis rs853679 0.769 rs7752608 chr6:28301195 A/G cg03623178 chr6:28175578 NA 0.76 6.07 0.32 3.43e-9 Depression; CRC cis rs6952808 0.692 rs11773316 chr7:2027354 C/T cg22963979 chr7:1858916 MAD1L1 -0.52 -7.57 -0.39 3.77e-13 Bipolar disorder and schizophrenia; CRC trans rs3008870 0.583 rs3008861 chr1:67396222 T/G cg01448155 chr10:3564782 NA -0.5 -6.03 -0.32 4.43e-9 Lymphocyte percentage of white cells; CRC cis rs7615952 0.599 rs1044215 chr3:125725559 C/G cg15145296 chr3:125709740 NA -0.54 -7.03 -0.36 1.19e-11 Blood pressure (smoking interaction); CRC cis rs2274471 0.678 rs7867965 chr9:5104574 G/T cg03390472 chr9:5043263 JAK2 -0.54 -6.29 -0.33 9.83e-10 Crohn's disease; CRC cis rs11608355 0.545 rs2302705 chr12:109898716 C/T cg05360138 chr12:110035743 NA 0.77 8.7 0.43 1.65e-16 Neuroticism; CRC cis rs1552244 0.882 rs3755783 chr3:10029289 A/G cg00166722 chr3:10149974 C3orf24 0.59 7.19 0.37 4.35e-12 Alzheimer's disease; CRC cis rs6963495 0.932 rs55700120 chr7:105148460 G/T cg02135003 chr7:105160482 PUS7 -0.89 -12.26 -0.56 9.87e-29 Bipolar disorder (body mass index interaction); CRC cis rs2228479 0.850 rs11648689 chr16:89806732 G/A cg19635926 chr16:89946313 TCF25 0.66 5.98 0.31 5.71e-9 Skin colour saturation; CRC cis rs73206853 0.925 rs61106808 chr12:110876009 C/G cg12870014 chr12:110450643 ANKRD13A 0.71 8.83 0.44 6.5e-17 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC cis rs6460942 1.000 rs2053378 chr7:12405564 C/G cg06484146 chr7:12443880 VWDE -0.74 -7.7 -0.39 1.56e-13 Coronary artery disease; CRC cis rs10504229 0.683 rs2318147 chr8:58114931 C/T cg22535103 chr8:58192502 C8orf71 -0.76 -8.65 -0.43 2.35e-16 Developmental language disorder (linguistic errors); CRC cis rs3820928 0.605 rs4281898 chr2:227855493 A/C cg11843606 chr2:227700838 RHBDD1 -0.46 -7.08 -0.36 8.58e-12 Pulmonary function; CRC trans rs3780486 0.757 rs10758189 chr9:33125804 A/G cg04842962 chr6:43655489 MRPS18A 1.14 25.38 0.81 1.74e-79 IgG glycosylation; CRC cis rs951366 0.764 rs708724 chr1:205743663 A/C cg23034840 chr1:205782522 SLC41A1 0.48 6.7 0.35 9.11e-11 Menarche (age at onset); CRC cis rs9399135 1.000 rs4475342 chr6:135283348 T/C cg22676075 chr6:135203613 NA 0.41 6.3 0.33 9.69e-10 Red blood cell count; CRC cis rs7927771 1.000 rs7927771 chr11:47781306 A/G cg20307385 chr11:47447363 PSMC3 -0.5 -6.58 -0.34 1.83e-10 Subjective well-being; CRC cis rs8099014 1.000 rs11152073 chr18:56108266 A/T cg12907477 chr18:56117327 MIR122 0.41 5.97 0.31 6.04e-9 Platelet count; CRC cis rs2797160 1.000 rs1739352 chr6:126005310 T/C cg05901451 chr6:126070800 HEY2 -0.4 -6.18 -0.32 1.93e-9 Endometrial cancer; CRC trans rs9956878 0.555 rs8085188 chr18:73544676 A/G cg26089074 chr17:17184578 COPS3 -0.35 -5.98 -0.31 5.91e-9 Obesity-related traits; CRC cis rs561341 1.000 rs1681718 chr17:30296445 G/A cg23018236 chr17:30244563 NA -0.65 -7.78 -0.39 9.41e-14 Hip circumference adjusted for BMI; CRC cis rs1178968 1.000 rs12534600 chr7:72762721 C/T cg25889504 chr7:72793014 NA -0.54 -6.12 -0.32 2.63e-9 Triglyceride levels; CRC cis rs2257205 0.667 rs9899893 chr17:56754597 T/C cg25885038 chr17:56607967 SEPT4 -0.52 -5.69 -0.3 2.87e-8 Pancreatic cancer; CRC cis rs910873 0.505 rs6059969 chr20:33245284 T/C cg08999081 chr20:33150536 PIGU 0.49 6.04 0.32 4.21e-9 Melanoma; CRC cis rs9733 0.519 rs11807450 chr1:150677719 C/T cg15448220 chr1:150897856 SETDB1 0.49 6.99 0.36 1.53e-11 Tonsillectomy; CRC cis rs909674 0.818 rs5757680 chr22:39844793 C/T cg05872129 chr22:39784769 NA 0.48 8.47 0.42 8.52e-16 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; CRC cis rs61524473 1 rs61524473 chr15:45646283 T/C cg21132104 chr15:45694354 SPATA5L1 0.59 8.71 0.43 1.49e-16 Metabolite levels (small molecules and protein measures); CRC cis rs35110281 0.626 rs162388 chr21:44936032 G/A cg01579765 chr21:45077557 HSF2BP -0.37 -6.83 -0.35 4.05e-11 Mean corpuscular volume; CRC cis rs9992667 1.000 rs9992667 chr4:38680186 C/T cg19726192 chr4:38663646 FLJ13197 -0.71 -9.0 -0.44 1.79e-17 Eosinophil percentage of granulocytes; CRC trans rs9929218 0.906 rs4783571 chr16:68806778 C/T cg04657470 chr2:198365150 HSPE1;HSPD1 -0.82 -11.54 -0.54 4.33e-26 Colorectal cancer; CRC cis rs763014 0.966 rs7185390 chr16:666382 A/G cg02475695 chr16:616220 NHLRC4 0.46 7.54 0.38 4.54e-13 Height; CRC cis rs12908161 1.000 rs17601029 chr15:85347709 A/G cg17507749 chr15:85114479 UBE2QP1 0.6 8.47 0.42 8.24e-16 Schizophrenia; CRC cis rs7677751 0.767 rs890205 chr4:55063373 C/A cg17187183 chr4:55093834 PDGFRA 0.48 6.74 0.35 7.26e-11 Corneal astigmatism; CRC cis rs5753618 0.509 rs5753500 chr22:31578879 A/G cg07713946 chr22:31675144 LIMK2 -0.39 -5.64 -0.3 3.72e-8 Colorectal cancer; CRC cis rs66569888 0.789 rs17213078 chr2:106734065 G/A cg16099169 chr2:106886729 NA -0.54 -8.07 -0.41 1.37e-14 Facial morphology (factor 23); CRC cis rs40363 0.716 rs9926612 chr16:3540968 A/C cg05754148 chr16:3507555 NAT15 -0.65 -5.69 -0.3 2.79e-8 Tuberculosis; CRC cis rs4665809 1.000 rs2384323 chr2:26306473 C/T cg27170947 chr2:26402098 FAM59B -0.45 -6.06 -0.32 3.82e-9 Gut microbiome composition (summer); CRC cis rs887829 0.570 rs6736508 chr2:234595747 C/T cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.45 -7.05 -0.36 1.08e-11 Metabolic traits;Bilirubin levels;Cholelithiasis-related traits in sickle cell anemia;Metabolite levels;Total bilirubin levels in HIV-1 infection;Serum metabolite levels;Blood metabolite levels; CRC cis rs12142240 0.698 rs17357683 chr1:46815378 C/T cg14993813 chr1:46806288 NSUN4 -0.5 -6.4 -0.33 5.38e-10 Menopause (age at onset); CRC cis rs860295 0.702 rs2025669 chr1:155357609 G/A cg02153340 chr1:155202674 NA -0.57 -6.77 -0.35 5.96e-11 Body mass index; CRC cis rs6582630 0.593 rs7299329 chr12:38447943 G/C cg26384229 chr12:38710491 ALG10B 0.71 10.06 0.49 6.12e-21 Drug-induced liver injury (flucloxacillin); CRC cis rs873946 0.586 rs36084869 chr10:134566069 G/A cg26818010 chr10:134567672 INPP5A -0.71 -9.2 -0.45 4.39e-18 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CRC cis rs9611565 0.879 rs4820437 chr22:41761290 T/C cg03806693 chr22:41940476 POLR3H -0.76 -10.63 -0.51 7.01e-23 Vitiligo; CRC trans rs7267979 0.934 rs2482913 chr20:25405086 T/A cg17903999 chr18:56338584 MALT1 0.41 6.68 0.35 1.05e-10 Liver enzyme levels (alkaline phosphatase); CRC cis rs1552244 1.000 rs9809061 chr3:10085130 C/G cg08888203 chr3:10149979 C3orf24 0.7 10.01 0.48 8.99e-21 Alzheimer's disease; CRC trans rs2018683 0.624 rs2286220 chr7:28998699 G/C cg19402173 chr7:128379420 CALU -0.51 -7.73 -0.39 1.36e-13 Response to irinotecan and platinum-based chemotherapy in non-small-cell lung cancer; CRC cis rs910316 0.737 rs175055 chr14:75488946 T/G cg11812906 chr14:75593930 NEK9 -0.57 -8.73 -0.43 1.27e-16 Height; CRC cis rs4750440 0.614 rs898718 chr10:14027235 C/T cg00551146 chr10:14014579 FRMD4A 0.44 7.09 0.36 8.28e-12 Adiponectin levels; CRC cis rs116095464 0.558 rs9654452 chr5:299561 C/T cg22857025 chr5:266934 NA -1.24 -16.13 -0.66 1.57e-43 Breast cancer; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg12793864 chr3:14693121 C3orf19 0.44 6.11 0.32 2.81e-9 Response to antipsychotic treatment; CRC cis rs7512552 0.809 rs9436112 chr1:150406449 A/C cg15654264 chr1:150340011 RPRD2 0.58 8.5 0.42 6.79e-16 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); CRC cis rs4746818 1.000 rs9299502 chr10:70876934 C/T cg11621586 chr10:70884670 VPS26A 0.87 10.45 0.5 2.96e-22 Left atrial antero-posterior diameter; CRC cis rs10197940 0.686 rs12616688 chr2:152242099 C/G cg06191203 chr2:152266755 RIF1 -0.64 -9.34 -0.46 1.53e-18 Lung cancer; CRC cis rs801193 1.000 rs6958520 chr7:66151453 T/C cg18876405 chr7:65276391 NA 0.61 10.75 0.51 2.65e-23 Aortic root size; CRC cis rs7412746 0.658 rs11204750 chr1:150939744 C/A cg18016565 chr1:150552671 MCL1 0.44 6.17 0.32 2.03e-9 Melanoma; CRC cis rs1552244 1.000 rs112847840 chr3:10101652 C/T cg00166722 chr3:10149974 C3orf24 0.7 9.53 0.46 3.69e-19 Alzheimer's disease; CRC cis rs57994353 1.000 rs57994353 chr9:139356987 T/C cg13856295 chr9:139396418 NOTCH1 -0.43 -6.18 -0.32 1.9e-9 Eosinophil counts;Cutaneous squamous cell carcinoma; CRC cis rs10864907 0.614 rs7557537 chr2:113702530 T/C cg06156847 chr2:113672199 IL1F7 -0.45 -6.78 -0.35 5.59e-11 Pulmonary function; CRC trans rs3733585 0.699 rs6449172 chr4:9966036 A/T cg26043149 chr18:55253948 FECH -0.48 -7.44 -0.38 8.74e-13 Cleft plate (environmental tobacco smoke interaction); CRC cis rs2243480 0.711 rs1626926 chr7:65435792 C/T cg18252515 chr7:66147081 NA -1.06 -12.41 -0.56 2.93e-29 Diabetic kidney disease; CRC cis rs6460942 0.778 rs76030612 chr7:12462937 C/A cg06484146 chr7:12443880 VWDE -0.69 -8.55 -0.43 4.81e-16 Coronary artery disease; CRC trans rs2303319 0.504 rs12467613 chr2:162603216 G/T cg04551154 chr10:95462393 C10orf4 -0.75 -6.37 -0.33 6.43e-10 Cognitive function; CRC cis rs853679 1.000 rs1679732 chr6:28221264 G/A cg06470822 chr6:28175283 NA -0.63 -6.25 -0.33 1.24e-9 Depression; CRC cis rs2976388 0.566 rs6998746 chr8:143802456 A/C cg15511327 chr8:143859410 LYNX1 0.42 7.01 0.36 1.34e-11 Urinary tract infection frequency; CRC cis rs6541297 0.702 rs4846904 chr1:230279410 G/A cg05784532 chr1:230284198 GALNT2 0.43 6.01 0.31 4.79e-9 Coronary artery disease; CRC cis rs7487075 0.930 rs12814298 chr12:46837624 T/G cg22049899 chr12:47219821 SLC38A4 0.31 6.11 0.32 2.83e-9 Itch intensity from mosquito bite; CRC trans rs7937682 0.961 rs491937 chr11:111494947 A/T cg18187862 chr3:45730750 SACM1L 0.46 6.62 0.34 1.43e-10 Primary sclerosing cholangitis; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg13361393 chr22:24114971 MMP11 0.4 6.77 0.35 5.9e-11 Liver disease severity in Alagille syndrome; CRC cis rs3785574 0.962 rs9944483 chr17:61783553 G/T cg22520471 chr17:61851767 DDX42;CCDC47 -0.44 -6.11 -0.32 2.75e-9 Height; CRC trans rs12478296 0.901 rs59191623 chr2:243028595 G/A cg06834434 chr14:75079333 LTBP2 0.55 6.83 0.35 4.23e-11 Obesity-related traits; CRC cis rs7772486 0.686 rs9399565 chr6:146081906 G/T cg05347473 chr6:146136440 FBXO30 -0.37 -5.63 -0.3 3.92e-8 Lobe attachment (rater-scored or self-reported); CRC cis rs950776 0.518 rs952215 chr15:78819153 C/T cg06917634 chr15:78832804 PSMA4 -0.67 -10.85 -0.51 1.19e-23 Sudden cardiac arrest; CRC cis rs11809207 0.523 rs2783707 chr1:26504196 C/G cg00147160 chr1:26503991 CNKSR1 0.29 6.04 0.32 4.1e-9 Height; CRC trans rs8141529 0.507 rs5762936 chr22:29381377 A/G cg14911242 chr14:105892412 MTA1 -0.55 -6.41 -0.33 4.9e-10 Lymphocyte counts; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg13896783 chr2:159313876 CCDC148;PKP4 0.43 7.0 0.36 1.42e-11 Liver disease severity in Alagille syndrome; CRC cis rs1577917 0.958 rs13213551 chr6:86608701 G/A cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.51 -6.74 -0.35 7.09e-11 Response to antipsychotic treatment; CRC cis rs929354 0.772 rs3802126 chr7:156970281 G/A cg05182265 chr7:156933206 UBE3C -0.76 -14.38 -0.62 1.04e-36 Body mass index; CRC cis rs7208859 0.623 rs3752020 chr17:29111125 T/G cg01831904 chr17:28903510 LRRC37B2 -0.63 -6.45 -0.33 4.07e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs9911578 0.967 rs8072712 chr17:57162464 A/T cg12560992 chr17:57184187 TRIM37 0.95 18.04 0.71 4.61e-51 Intelligence (multi-trait analysis); CRC cis rs800160 0.777 rs2521283 chr11:2341572 A/G cg09785033 chr11:2336066 TSPAN32 -0.47 -5.7 -0.3 2.62e-8 Bacteremia; CRC cis rs2742417 1.000 rs1877933 chr3:45753487 C/T cg04837898 chr3:45731254 SACM1L -0.36 -5.92 -0.31 7.95e-9 Response to anti-depressant treatment in major depressive disorder; CRC cis rs9322193 0.923 rs9800736 chr6:149982417 A/G cg04369109 chr6:150039330 LATS1 -0.41 -5.64 -0.3 3.76e-8 Lung cancer; CRC cis rs651907 0.557 rs3864012 chr3:101397623 T/C cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.68 9.53 0.47 3.56e-19 Colorectal cancer; CRC cis rs11628318 0.802 rs6575926 chr14:103050183 G/A cg02094049 chr14:103021097 NA -0.53 -6.86 -0.35 3.49e-11 Platelet count; CRC cis rs875971 0.965 rs28682868 chr7:65689809 C/T cg00343986 chr7:65444356 GUSB -0.45 -6.68 -0.35 1.03e-10 Aortic root size; CRC cis rs10504229 0.636 rs77290284 chr8:58055269 G/T cg02725872 chr8:58115012 NA -0.57 -7.96 -0.4 2.76e-14 Developmental language disorder (linguistic errors); CRC cis rs1005277 0.540 rs11011351 chr10:38030525 A/G cg25517755 chr10:38738941 LOC399744 -0.45 -6.49 -0.34 3.24e-10 Extrinsic epigenetic age acceleration; CRC cis rs172166 0.543 rs1150691 chr6:28168033 A/G cg12172441 chr6:28176163 NA 0.46 6.5 0.34 2.97e-10 Cardiac Troponin-T levels; CRC cis rs763121 0.962 rs2071887 chr22:38879010 A/T cg06544989 chr22:39130855 UNC84B 0.46 7.32 0.37 1.97e-12 Menopause (age at onset); CRC cis rs9814567 1.000 rs6801596 chr3:134252114 C/T cg06541857 chr3:134203789 ANAPC13;CEP63 -0.38 -5.64 -0.3 3.64e-8 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC trans rs2727020 0.729 rs2204366 chr11:49349367 A/C cg21153622 chr11:89784906 NA 0.42 7.02 0.36 1.31e-11 Coronary artery disease; CRC cis rs6502050 0.835 rs8079389 chr17:80158656 T/G cg09264619 chr17:80180166 NA -0.36 -5.99 -0.31 5.64e-9 Life satisfaction; CRC cis rs6089584 0.546 rs6061980 chr20:60618877 G/A cg06108461 chr20:60628389 TAF4 -0.77 -12.58 -0.57 6.96e-30 Body mass index; CRC cis rs2718798 1 rs2718798 chr3:133492088 A/C cg01448562 chr3:133502909 NA -0.47 -7.46 -0.38 7.77e-13 Ankle injury; CRC cis rs6930083 0.527 rs9470367 chr6:36626932 G/C cg08179530 chr6:36648295 CDKN1A -0.56 -8.41 -0.42 1.28e-15 Coronary artery disease; CRC cis rs7781557 1.000 rs10487284 chr7:102470275 G/A cg18108683 chr7:102477205 FBXL13 -0.51 -6.65 -0.34 1.21e-10 Colorectal adenoma (advanced); CRC cis rs2153535 0.580 rs1414350 chr6:8472331 C/T cg07606381 chr6:8435919 SLC35B3 0.68 10.9 0.51 8.26e-24 Motion sickness; CRC cis rs7666738 0.830 rs4699589 chr4:98973889 A/G cg17366294 chr4:99064904 C4orf37 0.44 7.44 0.38 8.98e-13 Colonoscopy-negative controls vs population controls; CRC trans rs12699921 0.599 rs2723554 chr7:17841652 C/T cg02066331 chr6:17282778 RBM24 -0.35 -5.96 -0.31 6.43e-9 Fibrinogen levels; CRC cis rs1881797 0.527 rs78486847 chr1:247638515 C/T cg18198730 chr1:247681584 NA 0.63 6.91 0.36 2.52e-11 Acute lymphoblastic leukemia (childhood); CRC cis rs9611565 0.918 rs73176685 chr22:41781094 C/G cg06481639 chr22:41940642 POLR3H -0.49 -5.8 -0.3 1.58e-8 Vitiligo; CRC cis rs9648716 1.000 rs10251380 chr7:140586895 C/T cg10747023 chr7:140774559 NA 0.44 5.88 0.31 9.82e-9 Type 2 diabetes; CRC cis rs7255374 0.566 rs11666982 chr19:41531368 T/G cg20630647 chr19:41531805 NA 0.36 5.92 0.31 8.3e-9 DDT metabolite (p,p'-DDE levels); CRC cis rs477895 0.639 rs35858916 chr11:63950529 T/G cg19465662 chr11:63993652 NUDT22;TRPT1 0.72 8.85 0.44 5.59e-17 Mean platelet volume; CRC cis rs853679 0.517 rs9357063 chr6:28060005 G/A cg12172441 chr6:28176163 NA 0.61 7.3 0.37 2.21e-12 Depression; CRC cis rs2549003 0.966 rs10072571 chr5:131816711 A/C cg21138405 chr5:131827807 IRF1 0.57 11.33 0.53 2.39e-25 Asthma (sex interaction); CRC cis rs4363385 0.818 rs2070964 chr1:153004213 C/T cg25856811 chr1:152973957 SPRR3 -0.27 -7.42 -0.38 1.03e-12 Inflammatory skin disease; CRC cis rs875971 0.825 rs801202 chr7:66023929 C/T cg18252515 chr7:66147081 NA 0.43 6.23 0.32 1.44e-9 Aortic root size; CRC cis rs932541 1.000 rs6111154 chr20:16456201 T/C cg17003395 chr20:16555519 KIF16B 0.41 5.63 0.3 3.82e-8 Intelligence; CRC trans rs61931739 0.500 rs11053201 chr12:34453903 T/A cg26384229 chr12:38710491 ALG10B 0.66 8.7 0.43 1.63e-16 Morning vs. evening chronotype; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg22233093 chr11:65381871 MAP3K11 0.44 6.13 0.32 2.46e-9 Response to antipsychotic treatment; CRC cis rs9527 0.615 rs7073295 chr10:104672233 A/G cg04362960 chr10:104952993 NT5C2 0.59 8.44 0.42 9.97e-16 Arsenic metabolism; CRC cis rs7552404 0.727 rs12122939 chr1:76276353 T/C cg22875332 chr1:76189707 ACADM 0.57 7.47 0.38 7.29e-13 Blood metabolite levels;Acylcarnitine levels; CRC cis rs1178968 0.818 rs4717086 chr7:72777049 A/G cg25889504 chr7:72793014 NA 0.54 6.12 0.32 2.63e-9 Triglyceride levels; CRC trans rs7937682 1.000 rs505372 chr11:111507189 A/C cg18187862 chr3:45730750 SACM1L 0.5 7.16 0.37 5.46e-12 Primary sclerosing cholangitis; CRC cis rs924607 0.583 rs12516251 chr5:608939 C/T cg07001201 chr5:642380 CEP72 0.41 6.22 0.32 1.5e-9 Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia; CRC cis rs3760982 0.967 rs12463346 chr19:44292244 A/G cg12072164 chr19:44306565 LYPD5 0.4 6.24 0.33 1.37e-9 Breast cancer (estrogen-receptor negative);Breast cancer; CRC cis rs427943 0.778 rs28782181 chr21:46588817 G/A cg19498844 chr21:46707878 POFUT2;LOC642852 -0.43 -5.71 -0.3 2.59e-8 Body mass index; CRC cis rs7917772 0.599 rs2863717 chr10:104519829 A/G cg04362960 chr10:104952993 NT5C2 0.46 6.14 0.32 2.4e-9 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC cis rs868943 0.743 rs13213124 chr6:116335637 A/G cg18764771 chr6:116381957 FRK 0.26 6.34 0.33 7.74e-10 Total cholesterol levels; CRC cis rs7769051 0.522 rs34688576 chr6:133118214 C/T cg07930552 chr6:133119739 C6orf192 0.92 7.35 0.38 1.56e-12 Type 2 diabetes nephropathy; CRC cis rs6604026 0.740 rs6700585 chr1:93364156 T/G cg17283838 chr1:93427260 FAM69A -0.5 -6.92 -0.36 2.36e-11 Multiple sclerosis; CRC cis rs938554 0.737 rs10939637 chr4:9977577 A/G cg00071950 chr4:10020882 SLC2A9 0.47 6.65 0.34 1.21e-10 Blood metabolite levels; CRC cis rs736408 0.608 rs2239547 chr3:52855229 T/C cg11645453 chr3:52864694 ITIH4 0.56 9.77 0.47 5.87e-20 Bipolar disorder; CRC cis rs2019137 0.560 rs10206269 chr2:113990393 C/A cg21482265 chr2:113992762 PAX8;LOC440839;LOC654433 0.61 9.1 0.45 8.68e-18 Lymphocyte counts; CRC cis rs2836974 0.563 rs6517522 chr21:40553845 T/C cg11890956 chr21:40555474 PSMG1 0.73 11.19 0.52 7.66e-25 Cognitive function; CRC cis rs7605827 0.930 rs11889160 chr2:15605509 C/T cg19274914 chr2:15703543 NA 0.39 6.02 0.32 4.65e-9 Educational attainment (years of education); CRC cis rs6543140 0.929 rs7602207 chr2:103032366 C/G cg09003973 chr2:102972529 NA 0.41 5.68 0.3 2.96e-8 Blood protein levels; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg23323627 chr1:153895881 GATAD2B 0.5 7.27 0.37 2.67e-12 Response to antipsychotic treatment; CRC cis rs270601 0.770 rs10463891 chr5:131597392 C/T cg12564285 chr5:131593104 PDLIM4 -0.57 -11.02 -0.52 2.95e-24 Acylcarnitine levels; CRC cis rs4713118 0.784 rs9468219 chr6:27731755 C/A cg20933634 chr6:27740509 NA 0.64 9.13 0.45 7.25e-18 Parkinson's disease; CRC cis rs6951245 0.554 rs2070118 chr7:1132505 G/A cg21664854 chr7:1097933 C7orf50;GPR146 0.61 7.71 0.39 1.48e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs344364 0.511 rs62040571 chr16:1948514 C/G cg09830162 chr16:1889614 FAHD1;C16orf73 -0.77 -9.36 -0.46 1.32e-18 Glomerular filtration rate in chronic kidney disease; CRC cis rs7894051 0.764 rs12242667 chr10:135192346 G/C cg20534287 chr10:135191450 PAOX -0.81 -7.28 -0.37 2.43e-12 Lifespan; CRC cis rs7647973 1.000 rs11130190 chr3:49402137 T/C cg07636037 chr3:49044803 WDR6 0.65 7.81 0.4 7.8e-14 Menarche (age at onset); CRC cis rs6951245 0.507 rs11976805 chr7:1138716 C/T cg04025307 chr7:1156635 C7orf50 0.74 10.24 0.49 1.47e-21 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs2836974 0.583 rs9981884 chr21:40585633 G/A cg06238570 chr21:40685208 BRWD1 0.43 5.9 0.31 9.24e-9 Cognitive function; CRC trans rs10982213 0.830 rs2274163 chr9:117188714 C/T cg12028816 chr17:7232827 NEURL4 0.39 6.09 0.32 3.13e-9 Interleukin-6 levels; CRC cis rs6951245 1.000 rs884977 chr7:1066410 T/C cg04025307 chr7:1156635 C7orf50 0.48 5.9 0.31 9.05e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs17345786 1.000 rs11715368 chr3:101336380 G/A cg11279151 chr3:101281821 RG9MTD1 -0.7 -8.86 -0.44 5.25e-17 Colonoscopy-negative controls vs population controls; CRC cis rs896854 0.625 rs4735336 chr8:95973410 A/C cg13393036 chr8:95962371 TP53INP1 0.51 8.73 0.43 1.29e-16 Type 2 diabetes; CRC cis rs35522438 1 rs35522438 chr7:91872872 A/AT cg17063962 chr7:91808500 NA 0.82 14.42 0.62 7.03e-37 Breast cancer; CRC cis rs9896052 0.534 rs8065160 chr17:73441090 A/G cg21038819 chr17:73507788 CASKIN2 -0.41 -5.76 -0.3 1.89e-8 Sight-threatening diabetic retinopathy in type 2 diabetes; CRC cis rs965469 1.000 rs6051779 chr20:3333449 A/G cg25506879 chr20:3388711 C20orf194 -0.39 -5.81 -0.31 1.44e-8 IFN-related cytopenia; CRC cis rs10256972 0.577 rs6962809 chr7:1208889 A/G cg07092213 chr7:1199455 ZFAND2A -0.48 -7.01 -0.36 1.37e-11 Longevity;Endometriosis; CRC cis rs9549260 0.755 rs4943797 chr13:41201633 A/G cg21288729 chr13:41239152 FOXO1 -0.45 -7.08 -0.36 8.72e-12 Red blood cell count; CRC cis rs2050392 0.767 rs2183175 chr10:30699336 A/G cg25182066 chr10:30743637 MAP3K8 0.44 6.14 0.32 2.39e-9 Inflammatory bowel disease; CRC cis rs7811142 1.000 rs73161759 chr7:100009994 T/C cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.97 13.45 0.6 3.81e-33 Platelet count; CRC cis rs4862750 0.872 rs7671914 chr4:187878165 A/G cg03452623 chr4:187889614 NA -0.87 -19.51 -0.73 7.12e-57 Lobe attachment (rater-scored or self-reported); CRC trans rs7945404 0.548 rs4936618 chr11:121223996 G/T cg27192990 chr6:129479024 LAMA2 0.43 6.04 0.32 4.11e-9 QT interval; CRC cis rs9911578 1.000 rs12938772 chr17:56776320 T/C cg12560992 chr17:57184187 TRIM37 0.9 16.1 0.66 2.05e-43 Intelligence (multi-trait analysis); CRC trans rs1814175 0.817 rs6486046 chr11:49997017 T/C cg11707556 chr5:10655725 ANKRD33B -0.42 -7.89 -0.4 4.58e-14 Height; CRC cis rs1656402 1.000 rs2573217 chr2:233427015 G/A cg03852847 chr2:233439513 NA 0.45 7.66 0.39 2.1e-13 Non-small cell lung cancer (survival); CRC cis rs9868809 0.881 rs34368826 chr3:48670827 G/T cg00383909 chr3:49044727 WDR6 0.77 7.67 0.39 1.98e-13 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; CRC cis rs9914988 0.887 rs9895625 chr17:27108516 A/G cg07195577 chr17:27052828 TLCD1 0.42 6.02 0.32 4.64e-9 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs12477438 0.520 rs4851188 chr2:99745898 G/A cg26064155 chr2:99771622 LIPT1;TSGA10 0.78 13.38 0.59 6.83e-33 Chronic sinus infection; CRC cis rs34311866 0.808 rs11728344 chr4:963755 T/C cg07828340 chr4:882639 GAK 1.1 10.4 0.5 4.45e-22 Parkinson's disease; CRC cis rs3091242 0.933 rs11249251 chr1:25770188 C/G cg23205692 chr1:25664452 TMEM50A 0.4 5.68 0.3 2.93e-8 Erythrocyte sedimentation rate; CRC trans rs991639 0.654 rs17019429 chr3:80797 A/T cg08213608 chr4:3748254 NA 0.47 6.07 0.32 3.6e-9 Problematic alcohol use in trauma-exposed individuals; CRC cis rs7493 0.950 rs17879277 chr7:95030632 A/C cg04155289 chr7:94953770 PON1 -0.61 -7.58 -0.39 3.56e-13 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs4555082 0.834 rs2735822 chr14:105712734 C/T cg18132624 chr14:105716052 BTBD6;BRF1 -0.51 -8.19 -0.41 5.7e-15 Mean platelet volume;Platelet distribution width; CRC cis rs10504229 0.679 rs11786328 chr8:58039269 A/G cg21724239 chr8:58056113 NA 0.72 8.94 0.44 2.96e-17 Developmental language disorder (linguistic errors); CRC cis rs1044826 0.642 rs1080371 chr3:139210894 C/T cg15131784 chr3:139108705 COPB2 0.39 5.63 0.3 3.79e-8 Obesity-related traits; CRC cis rs28386778 0.863 rs2665834 chr17:61904724 T/C cg22520471 chr17:61851767 DDX42;CCDC47 0.75 11.79 0.55 5.3e-27 Prudent dietary pattern; CRC cis rs6952808 0.929 rs11761270 chr7:1923695 C/T cg22963979 chr7:1858916 MAD1L1 -0.51 -7.64 -0.39 2.46e-13 Bipolar disorder and schizophrenia; CRC cis rs12893668 0.572 rs2273175 chr14:104160141 T/C cg24130564 chr14:104152367 KLC1 -0.43 -5.89 -0.31 9.69e-9 Reticulocyte count; CRC cis rs10504229 0.683 rs7817188 chr8:58129549 C/T cg02725872 chr8:58115012 NA -0.64 -11.55 -0.54 3.85e-26 Developmental language disorder (linguistic errors); CRC cis rs1008375 0.606 rs6828925 chr4:17561139 C/T cg16339924 chr4:17578868 LAP3 0.44 5.7 0.3 2.64e-8 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs67311347 1.000 rs2887995 chr3:40409029 C/G cg09455208 chr3:40491958 NA 0.43 8.9 0.44 3.69e-17 Renal cell carcinoma; CRC trans rs2243480 1.000 rs316329 chr7:65608416 A/C cg10756647 chr7:56101905 PSPH 0.71 7.6 0.39 3.2e-13 Diabetic kidney disease; CRC cis rs55788414 0.860 rs9929059 chr16:81182117 G/C cg06400318 chr16:81190750 PKD1L2 -0.59 -6.77 -0.35 6.02e-11 Left ventricular obstructive tract defect (maternal effect); CRC cis rs853679 0.517 rs12332979 chr6:28141548 T/G cg12963246 chr6:28129442 ZNF389 0.5 5.75 0.3 2e-8 Depression; CRC cis rs6901250 0.744 rs636872 chr6:117087944 C/T cg12892004 chr6:117198278 RFX6 0.39 6.15 0.32 2.3e-9 C-reactive protein levels; CRC cis rs2836974 0.931 rs7283569 chr21:40644062 T/G cg11890956 chr21:40555474 PSMG1 1.11 19.05 0.72 4.69e-55 Cognitive function; CRC cis rs9486715 0.838 rs7770889 chr6:96858453 C/T cg18709589 chr6:96969512 KIAA0776 -0.41 -5.99 -0.31 5.64e-9 Headache; CRC trans rs75246769 0.706 rs77271013 chr7:145692412 G/A cg21982490 chr5:124845866 NA -0.69 -5.98 -0.31 5.89e-9 Facial morphology (factor 10, width of nasal floor); CRC cis rs11601602 0.531 rs35031414 chr11:28545563 T/C cg06544937 chr11:28130018 METT5D1;KIF18A 0.62 6.99 0.36 1.57e-11 Obesity-related traits; CRC cis rs8141529 0.778 rs5762795 chr22:29182500 C/A cg15103426 chr22:29168792 CCDC117 0.57 8.23 0.41 4.57e-15 Lymphocyte counts; CRC trans rs629535 0.862 rs662725 chr8:70029616 C/T cg21567404 chr3:27674614 NA 0.95 15.98 0.66 5.8e-43 Dupuytren's disease; CRC cis rs875971 0.767 rs1695815 chr7:65831344 A/G cg18912574 chr7:65842487 NCRNA00174 0.36 6.18 0.32 1.88e-9 Aortic root size; CRC cis rs7107174 1.000 rs2510054 chr11:77959659 A/G cg02023728 chr11:77925099 USP35 -0.48 -7.54 -0.38 4.6e-13 Testicular germ cell tumor; CRC cis rs17767392 0.958 rs34480562 chr14:71979724 G/C cg13720639 chr14:72061746 SIPA1L1 -0.57 -7.26 -0.37 2.77e-12 Mitral valve prolapse; CRC cis rs9908102 0.637 rs8078508 chr17:12910523 G/A cg26162695 chr17:12921313 ELAC2 0.43 5.85 0.31 1.17e-8 Schizophrenia; CRC cis rs7666738 0.962 rs2865991 chr4:99067369 C/A cg17366294 chr4:99064904 C4orf37 0.46 7.35 0.38 1.62e-12 Colonoscopy-negative controls vs population controls; CRC cis rs3733585 0.699 rs1122142 chr4:9947548 G/C cg00071950 chr4:10020882 SLC2A9 -0.56 -9.88 -0.48 2.46e-20 Cleft plate (environmental tobacco smoke interaction); CRC cis rs7945705 0.791 rs10769958 chr11:8815115 T/C cg14711859 chr11:8959438 ASCL3 0.33 5.61 0.3 4.36e-8 Hemoglobin concentration; CRC cis rs7666738 0.924 rs13124368 chr4:99039615 T/C cg05340658 chr4:99064831 C4orf37 0.6 9.45 0.46 6.36e-19 Colonoscopy-negative controls vs population controls; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg07338698 chr17:79895532 PYCR1 0.43 6.25 0.33 1.24e-9 Intelligence (multi-trait analysis); CRC trans rs7267979 0.966 rs6083817 chr20:25343998 G/C cg17903999 chr18:56338584 MALT1 0.43 7.12 0.37 6.83e-12 Liver enzyme levels (alkaline phosphatase); CRC cis rs2440129 0.611 rs1126667 chr17:6902760 C/T cg09737314 chr17:6899359 ALOX12 -0.59 -10.64 -0.51 6.42e-23 Tonsillectomy; CRC cis rs9911578 0.933 rs2531725 chr17:56517962 G/A cg12560992 chr17:57184187 TRIM37 0.89 15.86 0.66 1.86e-42 Intelligence (multi-trait analysis); CRC cis rs3820068 0.559 rs6675334 chr1:15923580 A/T cg27534772 chr1:16042836 PLEKHM2 0.56 10.93 0.52 6.06e-24 Systolic blood pressure; CRC cis rs1538970 0.961 rs4660854 chr1:45854087 A/T cg05343316 chr1:45956843 TESK2 0.71 10.09 0.49 5.05e-21 Platelet count; CRC cis rs7474896 0.583 rs4934898 chr10:37990395 G/C cg25427524 chr10:38739819 LOC399744 -0.58 -7.2 -0.37 4.05e-12 Obesity (extreme); CRC cis rs2739330 0.828 rs4822454 chr22:24255208 G/A cg04234412 chr22:24373322 LOC391322 -0.71 -11.63 -0.54 1.96e-26 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs7224685 0.501 rs11652060 chr17:4010412 A/T cg05562828 chr17:3906858 NA -0.66 -11.48 -0.53 7.1e-26 Type 2 diabetes; CRC trans rs11039798 0.557 rs683180 chr11:48463949 A/G cg15704280 chr7:45808275 SEPT13 -0.64 -6.79 -0.35 5.11e-11 Axial length; CRC cis rs7487075 0.820 rs4768113 chr12:46708036 T/A cg22049899 chr12:47219821 SLC38A4 0.34 6.54 0.34 2.31e-10 Itch intensity from mosquito bite; CRC cis rs9858542 0.953 rs1987628 chr3:49399259 G/A cg03060546 chr3:49711283 APEH -0.48 -6.81 -0.35 4.64e-11 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs11614062 1.000 rs11614062 chr12:93956672 A/T cg18151635 chr12:93972918 NA -0.79 -10.09 -0.49 5.03e-21 Height; CRC cis rs2032447 0.520 rs198818 chr6:26125711 A/C cg12310025 chr6:25882481 NA 0.45 6.22 0.32 1.53e-9 Intelligence (multi-trait analysis); CRC cis rs9814567 1.000 rs1880377 chr3:134270468 T/C cg06541857 chr3:134203789 ANAPC13;CEP63 0.39 5.74 0.3 2.15e-8 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC trans rs66573146 1.000 rs66573146 chr4:6984464 C/G cg07817883 chr1:32538562 TMEM39B 1.51 13.37 0.59 7.39e-33 Granulocyte percentage of myeloid white cells; CRC cis rs1799949 0.965 rs12950779 chr17:41306523 C/T cg19454999 chr17:41278357 BRCA1;NBR2 0.55 8.69 0.43 1.69e-16 Menopause (age at onset); CRC cis rs6952809 0.590 rs1468337 chr7:2432211 C/T cg23289794 chr7:2394357 EIF3B -0.7 -8.78 -0.44 9.03e-17 Multiple sclerosis; CRC cis rs7249142 0.549 rs3787040 chr19:19297292 A/G cg12558012 chr19:19281197 LOC729991-MEF2B;MEF2B 0.58 9.45 0.46 6.7e-19 IgG glycosylation; CRC cis rs2303759 0.918 rs10405465 chr19:49869298 C/T cg22133161 chr19:49891603 CCDC155 0.48 6.79 0.35 5.23e-11 Multiple sclerosis; CRC cis rs875971 0.800 rs427557 chr7:65519250 A/G cg11764359 chr7:65958608 NA 0.57 9.0 0.44 1.85e-17 Aortic root size; CRC cis rs3096299 0.900 rs2911258 chr16:89480760 A/G cg01788221 chr16:89496183 ANKRD11 -0.46 -7.06 -0.36 9.9e-12 Multiple myeloma (IgH translocation); CRC trans rs6499188 0.522 rs10153230 chr16:68671741 C/G cg04657470 chr2:198365150 HSPE1;HSPD1 0.62 8.19 0.41 5.85e-15 Ulcerative colitis; CRC cis rs2717559 0.542 rs10956986 chr8:143886601 C/T cg15511327 chr8:143859410 LYNX1 -0.62 -11.17 -0.52 8.8e-25 Urinary tract infection frequency; CRC cis rs6714710 0.603 rs78006955 chr2:98455510 G/C cg26665480 chr2:98280029 ACTR1B 0.52 7.18 0.37 4.53e-12 Posterior cortical atrophy and Alzheimer's disease; CRC cis rs9926296 0.605 rs3743859 chr16:89846050 A/G cg21285383 chr16:89894308 SPIRE2 -0.33 -5.66 -0.3 3.38e-8 Vitiligo; CRC cis rs514406 0.644 rs928451 chr1:53195800 A/G cg25767906 chr1:53392781 SCP2 0.42 6.66 0.34 1.15e-10 Monocyte count; CRC trans rs1005277 0.579 rs2474580 chr10:38398713 G/A cg17830980 chr10:43048298 ZNF37B -0.6 -9.98 -0.48 1.19e-20 Extrinsic epigenetic age acceleration; CRC cis rs9916302 0.861 rs33933929 chr17:37426441 A/C cg00129232 chr17:37814104 STARD3 -0.55 -8.05 -0.41 1.5e-14 Glomerular filtration rate (creatinine); CRC cis rs2760061 0.583 rs708110 chr1:228190805 T/A cg02753203 chr1:228287806 NA 0.87 12.73 0.57 1.86e-30 Diastolic blood pressure; CRC trans rs10983614 1.000 rs7867776 chr9:120072627 A/G cg14577476 chr17:49337432 MBTD1;UTP18 0.42 6.19 0.32 1.81e-9 Survival in pancreatic cancer; CRC cis rs12024301 0.557 rs12048186 chr1:183611003 A/C cg11505048 chr1:183622726 RGL1;APOBEC4 0.81 7.0 0.36 1.42e-11 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs7772486 0.641 rs9390370 chr6:146357569 C/T cg23711669 chr6:146136114 FBXO30 0.58 8.39 0.42 1.44e-15 Lobe attachment (rater-scored or self-reported); CRC cis rs1401999 0.650 rs3792585 chr3:183646222 A/G cg01324343 chr3:183735012 ABCC5 0.6 9.5 0.46 4.63e-19 Anterior chamber depth; CRC cis rs4713118 0.696 rs2394002 chr6:27748015 G/A cg12273811 chr6:28175739 NA 0.5 6.66 0.34 1.18e-10 Parkinson's disease; CRC cis rs34375054 0.573 rs12831151 chr12:125656263 C/T cg25124228 chr12:125621409 AACS -0.56 -6.72 -0.35 7.79e-11 Post bronchodilator FEV1/FVC ratio; CRC cis rs6973256 0.828 rs9649046 chr7:133433402 C/T cg10665199 chr7:133106180 EXOC4 -0.38 -5.76 -0.3 1.96e-8 Intelligence (multi-trait analysis); CRC cis rs755249 0.567 rs61779274 chr1:39816941 C/G cg18385671 chr1:39797026 MACF1 -0.41 -5.77 -0.3 1.81e-8 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs4970988 0.556 rs6695123 chr1:150563483 T/C cg18016565 chr1:150552671 MCL1 -0.52 -7.64 -0.39 2.4e-13 Urate levels; CRC cis rs55823223 0.618 rs11867339 chr17:73862093 A/G cg08125733 chr17:73851984 WBP2 1.0 12.88 0.58 5.14e-31 Psoriasis; CRC cis rs1862618 0.802 rs42769 chr5:56144152 G/A cg03609598 chr5:56110824 MAP3K1 -0.83 -10.27 -0.49 1.2e-21 Initial pursuit acceleration; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg02415717 chr17:45727607 KPNB1 0.37 6.13 0.32 2.52e-9 Liver disease severity in Alagille syndrome; CRC trans rs116095464 0.558 rs10475136 chr5:232796 A/G cg00938859 chr5:1591904 SDHAP3 0.7 7.5 0.38 6.13e-13 Breast cancer; CRC cis rs2032447 0.867 rs9295683 chr6:26069495 C/T cg12310025 chr6:25882481 NA -0.42 -6.01 -0.31 4.92e-9 Intelligence (multi-trait analysis); CRC cis rs524281 0.861 rs2177053 chr11:65966145 A/C cg16950941 chr11:66035639 RAB1B -0.61 -7.57 -0.39 3.88e-13 Electroencephalogram traits; CRC cis rs780096 0.565 rs780104 chr2:27677691 G/A cg21248554 chr2:27665150 KRTCAP3 -0.33 -7.82 -0.4 7.44e-14 Total body bone mineral density; CRC cis rs172166 0.611 rs203882 chr6:28078502 G/A cg15845792 chr6:28175446 NA 0.8 11.59 0.54 2.82e-26 Cardiac Troponin-T levels; CRC cis rs17125944 0.686 rs77625717 chr14:53336544 T/C cg00686598 chr14:53173677 PSMC6 0.87 7.11 0.36 7.44e-12 Alzheimer's disease (late onset); CRC cis rs1005224 0.853 rs6574251 chr14:76136883 C/T cg04684003 chr14:76127793 TTLL5;C14orf1 -0.49 -7.28 -0.37 2.46e-12 Large artery stroke; CRC cis rs71403859 0.803 rs17282500 chr16:71633653 C/A cg08717414 chr16:71523259 ZNF19 -1.14 -10.91 -0.52 7.62e-24 Post bronchodilator FEV1; CRC cis rs4380275 1.000 rs4380275 chr2:773278 C/T cg27237671 chr2:676223 TMEM18 -0.43 -6.11 -0.32 2.76e-9 Adverse response to chemotherapy (neutropenia/leucopenia) (doxorubicin); CRC cis rs9527 1.000 rs9527 chr10:104623578 C/T cg04362960 chr10:104952993 NT5C2 0.64 7.74 0.39 1.24e-13 Arsenic metabolism; CRC cis rs9534288 0.830 rs1126365 chr13:46633196 T/A cg15192986 chr13:46630673 CPB2 -0.78 -10.96 -0.52 5.02e-24 Blood protein levels; CRC cis rs875971 0.862 rs1612452 chr7:65573896 T/A cg18252515 chr7:66147081 NA 0.39 5.69 0.3 2.85e-8 Aortic root size; CRC trans rs2243480 1.000 rs13247184 chr7:65358928 A/G cg10756647 chr7:56101905 PSPH 0.69 7.1 0.36 7.8e-12 Diabetic kidney disease; CRC cis rs9527 0.590 rs12355120 chr10:104852166 T/G cg04362960 chr10:104952993 NT5C2 0.61 8.53 0.43 5.25e-16 Arsenic metabolism; CRC cis rs9611565 0.659 rs9611603 chr22:41912750 A/G cg03806693 chr22:41940476 POLR3H -1.11 -15.12 -0.64 1.43e-39 Vitiligo; CRC cis rs4319547 1.000 rs4319547 chr12:123079035 A/G cg23029597 chr12:123009494 RSRC2 -0.65 -8.21 -0.41 5.22e-15 Body mass index; CRC cis rs6951245 0.748 rs79658522 chr7:1095877 A/G cg20603222 chr7:1096387 C7orf50;GPR146 -0.72 -8.67 -0.43 1.96e-16 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs951366 0.617 rs708727 chr1:205767885 G/A cg23034840 chr1:205782522 SLC41A1 0.56 7.98 0.4 2.49e-14 Menarche (age at onset); CRC cis rs939584 1.000 rs1320337 chr2:649867 A/T cg03610516 chr2:642275 NA -0.42 -5.91 -0.31 8.4e-9 Body mass index; CRC cis rs6534441 0.759 rs28756446 chr4:125461021 T/C cg21609808 chr4:125404261 NA 0.4 5.75 0.3 2.01e-8 Major depressive disorder; CRC cis rs7618501 0.633 rs6446193 chr3:50059758 T/C cg24110177 chr3:50126178 RBM5 0.51 7.91 0.4 3.83e-14 Intelligence (multi-trait analysis); CRC cis rs9916302 0.904 rs7210488 chr17:37539819 T/G cg15445000 chr17:37608096 MED1 -0.44 -9.91 -0.48 1.93e-20 Glomerular filtration rate (creatinine); CRC cis rs6694672 0.867 rs510135 chr1:197187779 C/T cg13682187 chr1:196946512 CFHR5 0.49 6.92 0.36 2.31e-11 Asthma; CRC cis rs875971 0.825 rs7384021 chr7:66077904 A/G cg18252515 chr7:66147081 NA 0.43 6.14 0.32 2.35e-9 Aortic root size; CRC cis rs2270875 1.000 rs1553270 chr8:132996059 T/G cg24184792 chr8:132919238 EFR3A -0.61 -5.9 -0.31 9.02e-9 Response to cholinesterase inhibitors in Alzheimer's disease; CRC cis rs3736485 0.934 rs17609791 chr15:51874824 C/T cg08986416 chr15:51914746 DMXL2 -0.46 -6.56 -0.34 2.11e-10 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs72634258 0.945 rs12748993 chr1:8129507 A/G cg00042356 chr1:8021962 PARK7 0.63 7.03 0.36 1.19e-11 Inflammatory bowel disease; CRC cis rs6860806 0.632 rs4330455 chr5:131586349 T/C cg18301423 chr5:131593218 PDLIM4 0.36 6.81 0.35 4.71e-11 Breast cancer; CRC cis rs4332037 0.802 rs12113633 chr7:1932936 G/A cg23378565 chr7:2036160 MAD1L1 -0.46 -6.65 -0.34 1.23e-10 Bipolar disorder; CRC trans rs208520 0.909 rs62414636 chr6:67015723 T/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.83 9.86 0.48 2.82e-20 Exhaled nitric oxide output; CRC cis rs6456156 0.774 rs968333 chr6:167526198 A/T cg19688584 chr6:167529678 CCR6 0.33 6.09 0.32 3.1e-9 Primary biliary cholangitis; CRC trans rs1656966 1.000 rs1656966 chr3:186466252 C/T cg11777782 chr19:18284937 IFI30 0.41 6.23 0.32 1.45e-9 Myopia (pathological); CRC cis rs2204008 0.805 rs11180825 chr12:38242916 G/T cg26384229 chr12:38710491 ALG10B 0.69 9.22 0.45 3.69e-18 Bladder cancer; CRC cis rs10504229 1.000 rs1390411 chr8:58194146 C/A cg01721255 chr8:58191610 C8orf71 0.45 5.78 0.3 1.75e-8 Developmental language disorder (linguistic errors); CRC cis rs727505 1.000 rs7777947 chr7:124436063 T/G cg23710748 chr7:124431027 NA -0.66 -11.85 -0.55 3.23e-27 Lewy body disease; CRC cis rs6952808 0.689 rs11771625 chr7:2050401 C/T cg04267008 chr7:1944627 MAD1L1 -0.78 -11.2 -0.53 7.25e-25 Bipolar disorder and schizophrenia; CRC cis rs2108622 0.727 rs7254940 chr19:15984508 C/T cg13772218 chr19:15982569 NA 0.48 6.85 0.35 3.56e-11 Circulating phylloquinone levels;Vitamin E levels;Acenocoumarol maintenance dosage;Response to Vitamin E supplementation;Metabolite levels;Warfarin maintenance dose; CRC cis rs798554 0.660 rs2527694 chr7:2858240 T/C cg17321639 chr7:2759063 NA -0.4 -6.09 -0.32 3.15e-9 Height; CRC cis rs765787 0.530 rs12440238 chr15:45512905 T/C cg24006582 chr15:45444508 DUOX1 0.52 7.56 0.38 4.08e-13 Uric acid levels; CRC cis rs60871478 0.898 rs4725241 chr7:796883 C/T cg04727924 chr7:799746 HEATR2 -0.43 -6.38 -0.33 5.9e-10 Cerebrospinal P-tau181p levels; CRC cis rs9814567 1.000 rs7374325 chr3:134275601 G/C cg06541857 chr3:134203789 ANAPC13;CEP63 -0.4 -5.97 -0.31 6.01e-9 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs7932354 0.528 rs10769234 chr11:47084061 G/C cg03339077 chr11:47165057 C11orf49 0.43 5.95 0.31 6.94e-9 Bone mineral density (hip);Bone mineral density; CRC cis rs1862618 1.000 rs1862618 chr5:56096315 C/G cg18230493 chr5:56204884 C5orf35 -0.66 -8.6 -0.43 3.25e-16 Initial pursuit acceleration; CRC cis rs6952808 0.929 rs2280550 chr7:1976556 G/A cg02951883 chr7:2050386 MAD1L1 -0.69 -10.45 -0.5 2.91e-22 Bipolar disorder and schizophrenia; CRC cis rs9896933 0.732 rs590886 chr17:80767350 A/G cg15664640 chr17:80829946 TBCD 0.48 5.6 0.3 4.45e-8 Bone mineral accretion in asthma (oral corticosteroid dose interaction); CRC cis rs853679 0.517 rs4713150 chr6:28136212 G/A cg18032046 chr6:28092343 ZSCAN16 -0.51 -5.91 -0.31 8.73e-9 Depression; CRC trans rs12478296 0.685 rs12473450 chr2:242991746 C/T cg06834434 chr14:75079333 LTBP2 0.54 7.07 0.36 9.32e-12 Obesity-related traits; CRC cis rs477895 0.568 rs34838337 chr11:63870892 T/C cg23719950 chr11:63933701 MACROD1 -0.56 -7.26 -0.37 2.8e-12 Mean platelet volume; CRC cis rs2629540 0.824 rs1552345 chr10:126477406 A/G cg08799069 chr10:126477246 METTL10 -0.65 -9.01 -0.45 1.66e-17 Cocaine dependence; CRC cis rs8031584 0.678 rs4779790 chr15:31164595 T/C cg14829155 chr15:31115871 NA -0.66 -10.22 -0.49 1.81e-21 Huntington's disease progression; CRC trans rs3808502 0.526 rs36048422 chr8:11417144 T/C cg16141378 chr3:129829833 LOC729375 0.45 6.87 0.35 3.28e-11 Neuroticism; CRC cis rs1580019 0.713 rs2167274 chr7:32524844 A/G cg14728415 chr7:32535168 LSM5;AVL9 0.45 6.3 0.33 9.36e-10 Cognitive ability; CRC cis rs1401999 0.966 rs1533682 chr3:183634879 A/G cg05044414 chr3:183734942 ABCC5 0.47 8.21 0.41 4.96e-15 Anterior chamber depth; CRC cis rs644799 0.710 rs11021309 chr11:95501898 C/A cg25622487 chr11:95524042 FAM76B;CEP57 0.79 13.11 0.59 6.77e-32 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs12900413 0.687 rs28465116 chr15:90310152 T/C cg24249390 chr15:90295951 MESP1 -0.58 -9.33 -0.46 1.56e-18 Coronary artery aneurysm in Kawasaki disease; CRC cis rs889398 0.771 rs1500337 chr16:69901884 C/T cg00738113 chr16:70207722 CLEC18C 0.35 5.81 0.3 1.51e-8 Body mass index; CRC trans rs1005277 0.579 rs2474572 chr10:38385316 A/G cg11292332 chr7:45801988 SEPT13 -0.35 -6.33 -0.33 7.9e-10 Extrinsic epigenetic age acceleration; CRC cis rs873946 0.648 rs1543593 chr10:134553185 A/T cg26818010 chr10:134567672 INPP5A -0.69 -8.89 -0.44 4.26e-17 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CRC cis rs1451375 0.572 rs4948205 chr7:50557774 G/A cg18232548 chr7:50535776 DDC -0.43 -5.67 -0.3 3.11e-8 Malaria; CRC cis rs3858526 0.959 rs10838795 chr11:5920721 A/G cg05234568 chr11:5960015 NA 0.52 7.21 0.37 3.83e-12 DNA methylation (variation); CRC cis rs9649213 0.614 rs10953254 chr7:97914305 A/G cg09267113 chr7:98030324 BAIAP2L1 -0.88 -10.8 -0.51 1.85e-23 Prostate cancer (SNP x SNP interaction); CRC cis rs4566357 0.615 rs10198406 chr2:227913539 A/G cg11843606 chr2:227700838 RHBDD1 -0.44 -6.85 -0.35 3.54e-11 Coronary artery disease; CRC cis rs113123495 0.609 rs2485275 chr19:5636672 A/T cg26242866 chr19:5711310 LONP1 0.7 5.76 0.3 1.88e-8 Obsessive-compulsive symptoms; CRC cis rs1862618 0.573 rs1550821 chr5:56242323 C/T cg18230493 chr5:56204884 C5orf35 0.87 12.03 0.55 6.99e-28 Initial pursuit acceleration; CRC cis rs9291683 0.566 rs13144709 chr4:10044182 C/T cg11266682 chr4:10021025 SLC2A9 0.52 10.62 0.51 7.35e-23 Bone mineral density; CRC cis rs66782572 1 rs66782572 chr3:52567617 A/G cg11645453 chr3:52864694 ITIH4 0.34 6.43 0.33 4.6e-10 Hemoglobin concentration; CRC cis rs894734 0.535 rs2366144 chr12:54324069 G/T cg17410650 chr12:54324560 NA -0.42 -7.98 -0.4 2.48e-14 Adverse response to chemotherapy (neutropenia/leucopenia) (all antimetabolite drugs); CRC cis rs1865760 1.000 rs9358893 chr6:25921761 A/G cg16482183 chr6:26056742 HIST1H1C 0.54 7.79 0.39 8.74e-14 Height; CRC cis rs172166 0.611 rs203882 chr6:28078502 G/A cg12172441 chr6:28176163 NA 0.53 7.17 0.37 5.02e-12 Cardiac Troponin-T levels; CRC cis rs7772486 0.597 rs9386136 chr6:146158300 A/T cg13319975 chr6:146136371 FBXO30 -0.62 -8.99 -0.44 2.04e-17 Lobe attachment (rater-scored or self-reported); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg00760200 chr1:115053833 TRIM33 0.47 7.58 0.39 3.44e-13 Liver disease severity in Alagille syndrome; CRC cis rs4713118 0.513 rs149959 chr6:28013854 T/C cg15845792 chr6:28175446 NA 0.77 11.38 0.53 1.58e-25 Parkinson's disease; CRC cis rs7909074 1.000 rs10736831 chr10:45402311 G/A cg04218760 chr10:45406644 TMEM72 -0.34 -9.68 -0.47 1.17e-19 Mean corpuscular volume; CRC cis rs2411233 1.000 rs8028719 chr15:39270782 C/T cg23129342 chr15:39283510 NA 0.31 5.64 0.3 3.68e-8 Platelet count; CRC cis rs7605827 0.930 rs4668450 chr2:15675011 C/T cg19274914 chr2:15703543 NA 0.39 5.87 0.31 1.07e-8 Educational attainment (years of education); CRC cis rs244731 0.959 rs6556307 chr5:176641434 C/T cg06060754 chr5:176797920 RGS14 0.57 7.32 0.37 1.89e-12 Urate levels in lean individuals; CRC cis rs473651 0.935 rs541013 chr2:239336492 G/A cg08773314 chr2:239334832 ASB1 0.38 8.65 0.43 2.26e-16 Multiple system atrophy; CRC cis rs58688157 0.924 rs35865896 chr11:584591 A/G cg03909863 chr11:638404 DRD4 -0.42 -6.11 -0.32 2.82e-9 Systemic lupus erythematosus; CRC cis rs11190604 1.000 rs2489043 chr10:102334327 T/C cg16342193 chr10:102329863 NA -0.33 -5.7 -0.3 2.65e-8 Palmitoleic acid (16:1n-7) levels; CRC trans rs11088226 1.000 rs11088226 chr21:33925531 C/G cg09050820 chr6:167586206 TCP10L2 0.59 6.59 0.34 1.74e-10 Gastritis; CRC trans rs11039798 0.588 rs10160381 chr11:48599491 A/G cg03929089 chr4:120376271 NA 0.66 7.21 0.37 3.85e-12 Axial length; CRC cis rs4862750 0.914 rs6553026 chr4:187875648 C/T cg07414643 chr4:187882934 NA 0.38 6.51 0.34 2.86e-10 Lobe attachment (rater-scored or self-reported); CRC cis rs2836633 0.929 rs11701577 chr21:40028906 C/T cg12884169 chr21:40033163 ERG 0.42 9.57 0.47 2.61e-19 Coronary artery disease; CRC cis rs6460942 0.908 rs73301032 chr7:12256799 C/G cg06484146 chr7:12443880 VWDE -0.56 -5.8 -0.3 1.58e-8 Coronary artery disease; CRC cis rs2276314 1.000 rs4799834 chr18:33566243 T/C cg05985134 chr18:33552581 C18orf21 0.46 6.43 0.33 4.37e-10 Endometriosis;Drug-induced torsades de pointes; CRC cis rs11098499 0.863 rs10034450 chr4:120455649 A/G cg09307838 chr4:120376055 NA 0.69 10.34 0.5 6.68e-22 Corneal astigmatism; CRC cis rs9914988 0.673 rs9890212 chr17:27169890 G/C cg12682573 chr17:27188876 MIR451;MIR144 0.54 7.49 0.38 6.22e-13 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs3750082 0.889 rs6963831 chr7:32934827 G/T cg05721444 chr7:32995514 FKBP9 0.49 7.51 0.38 5.49e-13 Glomerular filtration rate (creatinine); CRC cis rs13333054 1.000 rs12232384 chr16:86009760 A/C cg04454285 chr16:86016317 NA -0.77 -11.18 -0.52 8.46e-25 Multiple sclerosis; CRC cis rs9303401 0.614 rs2240719 chr17:56582477 G/C cg10487724 chr17:56770010 TEX14;RAD51C 0.79 9.78 0.47 5.43e-20 Cognitive test performance; CRC cis rs6681460 0.576 rs2859914 chr1:66989840 A/G cg02459107 chr1:67143332 SGIP1 0.38 5.76 0.3 1.97e-8 Presence of antiphospholipid antibodies; CRC cis rs10540 1.000 rs12417570 chr11:462684 C/T cg08200582 chr11:442649 ANO9 -0.67 -6.39 -0.33 5.74e-10 Body mass index; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg26912688 chr1:176176562 RFWD2 0.55 7.53 0.38 4.81e-13 Thyroid stimulating hormone; CRC cis rs7666738 0.830 rs3852123 chr4:98697586 A/G cg05340658 chr4:99064831 C4orf37 0.53 7.9 0.4 4.12e-14 Colonoscopy-negative controls vs population controls; CRC cis rs17767392 0.958 rs8010616 chr14:72019108 A/G cg13720639 chr14:72061746 SIPA1L1 0.56 7.14 0.37 6.03e-12 Mitral valve prolapse; CRC cis rs4689592 0.503 rs59640165 chr4:7051661 G/A cg19539972 chr4:7069911 GRPEL1 -0.81 -8.91 -0.44 3.59e-17 Monocyte percentage of white cells; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg22228043 chr1:11159903 EXOSC10 0.44 6.72 0.35 8.08e-11 Intelligence (multi-trait analysis); CRC cis rs2645694 0.626 rs2645705 chr4:77830434 G/A cg03477792 chr4:77819574 ANKRD56 0.46 6.62 0.34 1.48e-10 Emphysema distribution in smoking; CRC cis rs1448094 0.692 rs7958438 chr12:86326141 A/T cg00310523 chr12:86230176 RASSF9 0.44 7.42 0.38 1.02e-12 Major depressive disorder; CRC cis rs13108904 0.870 rs2291199 chr4:1244267 A/G cg24560729 chr4:1342394 KIAA1530 0.33 5.79 0.3 1.6e-8 Obesity-related traits; CRC cis rs1320333 0.772 rs2903491 chr2:686688 T/A cg00500140 chr2:691012 NA 0.63 6.93 0.36 2.19e-11 Obesity-related traits; CRC cis rs2228479 0.850 rs11649100 chr16:89798179 A/G cg19635926 chr16:89946313 TCF25 0.68 6.13 0.32 2.57e-9 Skin colour saturation; CRC trans rs10982213 0.830 rs2274163 chr9:117188714 C/T cg04131734 chr11:102323536 TMEM123 0.43 6.64 0.34 1.27e-10 Interleukin-6 levels; CRC cis rs2380220 0.640 rs9320386 chr6:95994955 T/C cg07718321 chr6:96025334 MANEA 0.52 6.11 0.32 2.82e-9 Behavioural disinhibition (generation interaction); CRC cis rs6502050 0.835 rs4247357 chr17:80166989 G/T cg02741985 chr17:80059408 CCDC57 0.42 6.99 0.36 1.53e-11 Life satisfaction; CRC cis rs2760061 0.598 rs632832 chr1:228121838 G/T cg02753203 chr1:228287806 NA -0.63 -9.65 -0.47 1.4e-19 Diastolic blood pressure; CRC cis rs2204008 0.805 rs2874289 chr12:38258420 G/A cg13010199 chr12:38710504 ALG10B 0.45 5.75 0.3 2.07e-8 Bladder cancer; CRC cis rs243505 0.660 rs10274535 chr7:148543525 A/G cg09806900 chr7:148480153 CUL1 0.52 6.63 0.34 1.38e-10 Inflammatory bowel disease;Crohn's disease; CRC cis rs7107174 0.901 rs2510053 chr11:77959435 T/C cg02023728 chr11:77925099 USP35 0.49 8.43 0.42 1.14e-15 Testicular germ cell tumor; CRC cis rs45509595 0.749 rs401763 chr6:27782528 T/C cg26587870 chr6:27730563 NA -0.6 -5.98 -0.31 5.78e-9 Breast cancer; CRC cis rs13315871 0.929 rs2056120 chr3:58309436 A/T cg20936604 chr3:58311152 NA -0.74 -7.76 -0.39 1.05e-13 Cholesterol, total; CRC cis rs4604732 0.631 rs12036460 chr1:247626928 A/G cg12758973 chr1:247694275 LOC148824;OR2C3 0.42 6.14 0.32 2.32e-9 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CRC cis rs9648716 1.000 rs6947950 chr7:140539665 A/G cg10747023 chr7:140774559 NA 0.44 5.76 0.3 1.94e-8 Type 2 diabetes; CRC trans rs10982213 0.830 rs2274163 chr9:117188714 C/T cg17544762 chr6:151300474 MTHFD1L 0.43 6.24 0.33 1.32e-9 Interleukin-6 levels; CRC cis rs2243480 1.000 rs781142 chr7:65438778 C/T cg18252515 chr7:66147081 NA -1.03 -12.21 -0.56 1.55e-28 Diabetic kidney disease; CRC cis rs9308731 0.644 rs4849403 chr2:111874037 T/C cg18646521 chr2:111875858 NA 0.36 5.63 0.3 3.77e-8 Chronic lymphocytic leukemia; CRC cis rs453301 0.571 rs2929305 chr8:9085217 G/A cg06636001 chr8:8085503 FLJ10661 -0.56 -9.07 -0.45 1.14e-17 Joint mobility (Beighton score); CRC cis rs4713118 0.784 rs9468219 chr6:27731755 C/A cg21251018 chr6:28226885 NKAPL 0.41 5.88 0.31 1.02e-8 Parkinson's disease; CRC cis rs6665290 0.669 rs3768424 chr1:227177444 A/G cg10327440 chr1:227177885 CDC42BPA -0.99 -21.25 -0.76 1.1e-63 Myeloid white cell count; CRC cis rs17162190 0.698 rs4659442 chr1:26823580 T/G cg17456097 chr1:26900765 RPS6KA1 0.42 6.15 0.32 2.25e-9 Mean corpuscular volume; CRC cis rs7274811 0.744 rs6141411 chr20:32157934 G/A cg03904042 chr20:32255491 NECAB3;C20orf134 -0.49 -7.14 -0.37 5.95e-12 Height; CRC cis rs9640161 0.789 rs28432021 chr7:150046235 G/C cg13722127 chr7:150037890 RARRES2 0.41 6.27 0.33 1.12e-9 Blood protein levels;Circulating chemerin levels; CRC cis rs77861329 1.000 rs9882775 chr3:52149649 C/T cg08692210 chr3:52188851 WDR51A 0.81 6.74 0.35 7.03e-11 Macrophage inflammatory protein 1b levels; CRC cis rs1552244 0.572 rs6783705 chr3:10164783 A/G cg10729496 chr3:10149963 C3orf24 0.48 5.61 0.3 4.19e-8 Alzheimer's disease; CRC cis rs28386778 0.897 rs10221279 chr17:61806138 A/G cg22520471 chr17:61851767 DDX42;CCDC47 0.73 11.17 0.52 9.08e-25 Prudent dietary pattern; CRC cis rs7113874 0.589 rs10769907 chr11:8457237 G/A cg02811074 chr11:8615871 STK33 -0.35 -5.91 -0.31 8.76e-9 Body mass index in physically active individuals;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs2050392 0.771 rs303446 chr10:30728489 C/T cg18806716 chr10:30721971 MAP3K8 -0.5 -7.62 -0.39 2.65e-13 Inflammatory bowel disease; CRC cis rs17092148 1.000 rs6060040 chr20:33359054 G/C cg08999081 chr20:33150536 PIGU 0.47 5.84 0.31 1.24e-8 Neuroticism; CRC cis rs2243480 1.000 rs6949812 chr7:65387101 G/A cg12463550 chr7:65579703 CRCP 0.63 6.04 0.32 4.17e-9 Diabetic kidney disease; CRC trans rs587242 1.000 rs7543671 chr1:96892268 T/C cg10631902 chr5:14652156 NA 0.45 6.9 0.36 2.7e-11 Body mass index (joint analysis main effects and physical activity interaction);Body mass index in physically inactive individuals;Body mass index; CRC cis rs11098499 0.954 rs13133522 chr4:120324424 A/T cg24375607 chr4:120327624 NA 0.51 7.98 0.4 2.49e-14 Corneal astigmatism; CRC trans rs11088226 0.681 rs2833911 chr21:33949629 C/T cg09050820 chr6:167586206 TCP10L2 -0.89 -9.25 -0.45 2.83e-18 Gastritis; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg05950833 chr1:32688296 C1orf91;EIF3I 0.47 6.83 0.35 4.14e-11 Intelligence (multi-trait analysis); CRC cis rs4290604 0.667 rs80185012 chr2:237958643 T/C cg23555395 chr2:238036564 NA 0.67 6.59 0.34 1.71e-10 Asthma; CRC cis rs4743820 0.620 rs7848226 chr9:93920117 C/G cg14446406 chr9:93919335 NA 0.82 15.22 0.64 5.85e-40 Ulcerative colitis;Inflammatory bowel disease; CRC trans rs8108034 1.000 rs39587 chr19:39806997 C/T cg23687437 chr15:64125745 HERC1 -0.58 -6.19 -0.32 1.84e-9 Lung adenocarcinoma; CRC trans rs2235573 0.625 rs713991 chr22:38426043 A/G cg19894588 chr14:64061835 NA 0.43 6.25 0.33 1.24e-9 Glioblastoma;Glioma; CRC cis rs10256972 0.685 rs10263665 chr7:1110628 A/G cg03923535 chr7:1197113 ZFAND2A 0.53 7.7 0.39 1.64e-13 Longevity;Endometriosis; CRC cis rs2576037 0.583 rs512699 chr18:44374681 C/T cg23996704 chr18:44553084 KATNAL2 0.32 6.22 0.32 1.48e-9 Personality dimensions; CRC cis rs7917772 0.508 rs2252147 chr10:104467774 G/A cg04362960 chr10:104952993 NT5C2 -0.49 -6.01 -0.31 4.97e-9 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC cis rs28386778 0.897 rs1062788 chr17:61896127 C/G cg06601766 chr17:61851465 DDX42;CCDC47 0.44 5.96 0.31 6.33e-9 Prudent dietary pattern; CRC cis rs10256972 0.621 rs10951594 chr7:1088607 C/G cg18765753 chr7:1198926 ZFAND2A -0.32 -5.73 -0.3 2.31e-8 Longevity;Endometriosis; CRC cis rs2274273 0.638 rs17672364 chr14:55705904 G/T cg10130446 chr14:55658398 DLGAP5 -0.43 -5.71 -0.3 2.53e-8 Protein biomarker; CRC cis rs116095464 0.558 rs6555058 chr5:226376 C/T cg22496380 chr5:211416 CCDC127 0.79 9.05 0.45 1.29e-17 Breast cancer; CRC cis rs10504229 0.683 rs2088217 chr8:58113124 C/T cg04204079 chr8:58130323 NA -0.46 -5.84 -0.31 1.22e-8 Developmental language disorder (linguistic errors); CRC cis rs7680126 0.500 rs4697935 chr4:10149593 C/T cg11266682 chr4:10021025 SLC2A9 -0.42 -6.24 -0.33 1.34e-9 Urate levels in lean individuals;Urate levels in overweight individuals;Urate levels in obese individuals; CRC cis rs7809950 0.530 rs34021916 chr7:106817901 A/G cg23024343 chr7:107201750 COG5 -0.67 -9.39 -0.46 1.07e-18 Coronary artery disease; CRC cis rs68170813 0.559 rs76534758 chr7:106963262 T/C cg02696742 chr7:106810147 HBP1 -0.58 -6.38 -0.33 5.85e-10 Coronary artery disease; CRC cis rs12541335 0.639 rs35068739 chr8:22201719 T/C cg09517075 chr8:22133004 PIWIL2 0.5 8.59 0.43 3.63e-16 Hypertriglyceridemia; CRC cis rs3749237 0.615 rs55957735 chr3:49438158 G/A cg07636037 chr3:49044803 WDR6 0.55 8.1 0.41 1.08e-14 Resting heart rate; CRC cis rs1656402 0.911 rs2880817 chr2:233453705 G/A cg03852847 chr2:233439513 NA -0.42 -7.26 -0.37 2.83e-12 Non-small cell lung cancer (survival); CRC trans rs7395662 1.000 rs10742862 chr11:48649316 T/C cg21153622 chr11:89784906 NA -0.44 -7.01 -0.36 1.38e-11 HDL cholesterol; CRC cis rs1799949 1.000 rs3950989 chr17:41237953 G/A cg05368731 chr17:41323189 NBR1 0.68 10.01 0.48 8.88e-21 Menopause (age at onset); CRC cis rs3818285 0.504 rs1973972 chr10:111651133 A/T cg00817464 chr10:111662876 XPNPEP1 0.43 6.0 0.31 5.25e-9 Superior crus of antihelix expression; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg23897067 chr9:140100305 TMEM203;NDOR1 0.44 6.36 0.33 6.61e-10 Intelligence (multi-trait analysis); CRC cis rs2439831 0.541 rs12440854 chr15:43610672 A/G cg15269541 chr15:43626905 ADAL -0.62 -6.38 -0.33 6.11e-10 Lung cancer in ever smokers; CRC cis rs3091242 0.900 rs1811832 chr1:25753565 G/A cg27572855 chr1:25598939 RHD 0.36 6.55 0.34 2.19e-10 Erythrocyte sedimentation rate; CRC cis rs4713118 0.539 rs200988 chr6:27819353 A/C cg10876282 chr6:28092338 ZSCAN16 0.43 5.7 0.3 2.64e-8 Parkinson's disease; CRC cis rs12477438 0.520 rs11677247 chr2:99756358 A/G cg26064155 chr2:99771622 LIPT1;TSGA10 0.88 16.2 0.67 8.61e-44 Chronic sinus infection; CRC cis rs1670533 1.000 rs6812596 chr4:1069866 A/G cg27284194 chr4:1044797 NA 0.48 6.07 0.32 3.51e-9 Recombination rate (females); CRC cis rs952623 0.501 rs11972294 chr7:39085743 A/G cg18850127 chr7:39170497 POU6F2 0.44 5.71 0.3 2.53e-8 Intelligence (multi-trait analysis); CRC cis rs6815814 0.851 rs73235002 chr4:38769018 A/G cg06935464 chr4:38784597 TLR10 0.57 5.69 0.3 2.8e-8 Breast cancer; CRC cis rs12701220 0.857 rs1057558 chr7:1062366 A/G cg02733842 chr7:1102375 C7orf50 -0.69 -8.48 -0.42 7.78e-16 Bronchopulmonary dysplasia; CRC cis rs3736485 0.868 rs1531155 chr15:51932133 T/C cg08986416 chr15:51914746 DMXL2 -0.46 -6.51 -0.34 2.88e-10 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs6502050 0.805 rs7406858 chr17:80080623 G/A cg19223190 chr17:80058835 NA -0.39 -6.09 -0.32 3.17e-9 Life satisfaction; CRC cis rs422249 0.511 rs102274 chr11:61557826 T/C cg06781209 chr11:61594997 FADS2 -0.39 -5.78 -0.3 1.69e-8 Trans fatty acid levels; CRC cis rs367615 0.704 rs17161885 chr5:108852642 A/G cg17395555 chr5:108820864 NA 0.43 8.37 0.42 1.63e-15 Colorectal cancer (SNP x SNP interaction); CRC cis rs4975616 0.773 rs10078017 chr5:1314009 C/T cg26373071 chr5:1325741 CLPTM1L -0.41 -7.03 -0.36 1.21e-11 Lung cancer; CRC cis rs5760092 0.755 rs915589 chr22:24261004 C/T cg24846343 chr22:24311635 DDTL -0.67 -7.49 -0.38 6.53e-13 Urinary 1,3-butadiene metabolite levels in smokers; CRC trans rs9329221 0.905 rs4433149 chr8:10249268 A/T cg06636001 chr8:8085503 FLJ10661 -0.56 -9.02 -0.45 1.61e-17 Neuroticism; CRC cis rs40363 0.951 rs250632 chr16:3523047 C/T cg05754148 chr16:3507555 NAT15 0.75 8.27 0.41 3.31e-15 Tuberculosis; CRC cis rs9682041 0.627 rs3772173 chr3:170078232 C/T cg11886554 chr3:170076028 SKIL 0.67 8.22 0.41 4.9e-15 Glomerular filtration rate in non diabetics (creatinine);Glomerular filtration rate (creatinine); CRC cis rs7927771 0.929 rs12787646 chr11:47669665 T/C cg05585544 chr11:47624801 NA -0.57 -10.41 -0.5 3.89e-22 Subjective well-being; CRC trans rs10982213 0.830 rs2274163 chr9:117188714 C/T cg01603508 chr16:30937154 FBXL19 -0.38 -6.11 -0.32 2.87e-9 Interleukin-6 levels; CRC cis rs60843830 1.000 rs59937473 chr2:271797 G/A cg00108164 chr2:264199 ACP1;SH3YL1 0.61 9.74 0.47 7.34e-20 Spherical equivalent (joint analysis main effects and education interaction); CRC cis rs6687430 0.526 rs12127400 chr1:10613660 C/T cg17425144 chr1:10567563 PEX14 0.46 9.45 0.46 6.61e-19 Hand grip strength; CRC cis rs1223397 1.000 rs1232392 chr6:13272671 C/G cg20827128 chr6:13274284 PHACTR1 0.56 6.78 0.35 5.42e-11 Blood pressure; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg13904018 chr4:1340886 KIAA1530 0.41 6.36 0.33 6.84e-10 Intelligence (multi-trait analysis); CRC cis rs6940638 0.688 rs7764984 chr6:27034181 A/G cg12292205 chr6:26970375 C6orf41 -0.49 -6.6 -0.34 1.66e-10 Intelligence (multi-trait analysis); CRC cis rs4363385 0.747 rs1611753 chr1:152956381 C/T cg25856811 chr1:152973957 SPRR3 -0.26 -7.27 -0.37 2.58e-12 Inflammatory skin disease; CRC cis rs938554 0.513 rs4529048 chr4:9997112 G/T cg11266682 chr4:10021025 SLC2A9 0.34 6.1 0.32 2.89e-9 Blood metabolite levels; CRC cis rs834811 0.602 rs17243556 chr7:135886489 T/A cg01726295 chr7:135938950 NA 0.36 6.11 0.32 2.74e-9 Post-traumatic stress disorder; CRC cis rs116095464 0.558 rs56342538 chr5:225796 T/C cg22857025 chr5:266934 NA -1.22 -16.66 -0.68 1.26e-45 Breast cancer; CRC cis rs17384381 0.700 rs11161617 chr1:85913538 A/G cg16011679 chr1:85725395 C1orf52 0.51 6.03 0.32 4.38e-9 Lobe attachment (rater-scored or self-reported); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg03075736 chr3:52444632 PHF7;BAP1 0.39 6.27 0.33 1.14e-9 Intelligence (multi-trait analysis); CRC cis rs2013441 0.965 rs2703808 chr17:20109665 A/C cg13482628 chr17:19912719 NA -0.42 -6.57 -0.34 1.95e-10 Obesity-related traits; CRC cis rs2735413 0.958 rs2735401 chr16:78057103 A/C cg04733911 chr16:78082701 NA 0.35 5.68 0.3 2.95e-8 Systolic blood pressure (alcohol consumption interaction); CRC cis rs12692738 0.526 rs391915 chr2:165623811 A/G cg03182029 chr2:165697222 COBLL1 0.5 5.88 0.31 1.02e-8 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);Waist-to-hip ratio adjusted for BMI in non-smokers;Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction);Waist-to-hip ratio adjusted for body mass index; CRC trans rs2303319 0.582 rs62187608 chr2:162431138 T/G cg14875682 chr5:52083620 ITGA1;PELO -0.76 -6.17 -0.32 2.05e-9 Cognitive function; CRC cis rs10752881 1.000 rs10752886 chr1:182987248 A/G ch.1.3577855R chr1:183094577 LAMC1 0.86 15.22 0.64 5.91e-40 Colorectal cancer; CRC cis rs2204008 0.685 rs4556621 chr12:38187236 C/A cg13010199 chr12:38710504 ALG10B 0.47 5.88 0.31 1.02e-8 Bladder cancer; CRC cis rs1218582 0.740 rs1977879 chr1:154879743 G/A cg16680214 chr1:154839983 KCNN3 -0.45 -8.95 -0.44 2.64e-17 Prostate cancer; CRC cis rs9611565 0.694 rs202664 chr22:41813886 C/T cg06481639 chr22:41940642 POLR3H 0.49 5.61 0.3 4.24e-8 Vitiligo; CRC cis rs7618501 0.699 rs9821675 chr3:49902544 A/G cg24308560 chr3:49941425 MST1R -0.5 -7.74 -0.39 1.26e-13 Intelligence (multi-trait analysis); CRC cis rs875971 0.545 rs2460427 chr7:65619205 T/C cg11764359 chr7:65958608 NA -0.47 -5.92 -0.31 8.3e-9 Aortic root size; CRC cis rs6582630 0.598 rs10880645 chr12:38556172 G/A cg13010199 chr12:38710504 ALG10B -0.42 -6.03 -0.32 4.43e-9 Drug-induced liver injury (flucloxacillin); CRC cis rs13108904 0.935 rs2293633 chr4:1291640 T/C cg21620606 chr4:1342894 KIAA1530 0.41 7.49 0.38 6.45e-13 Obesity-related traits; CRC cis rs28386778 0.897 rs2727295 chr17:61887693 C/T cg22520471 chr17:61851767 DDX42;CCDC47 0.67 10.6 0.5 9.1e-23 Prudent dietary pattern; CRC trans rs6951245 1.000 rs80031817 chr7:1096793 T/C cg13565492 chr6:43139072 SRF -0.71 -7.38 -0.38 1.32e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs1799949 1.000 rs11652332 chr17:41295489 G/A cg25072359 chr17:41440525 NA 0.44 6.46 0.34 3.83e-10 Menopause (age at onset); CRC cis rs4481887 0.741 rs6682953 chr1:248535626 T/C cg00666640 chr1:248458726 OR2T12 0.42 7.59 0.39 3.32e-13 Common traits (Other); CRC cis rs2737618 0.722 rs1986405 chr1:200095935 C/G cg21825944 chr1:200113062 NR5A2 -0.52 -7.61 -0.39 2.92e-13 Uric acid levels; CRC cis rs1355223 1.000 rs35365094 chr11:34767790 A/C cg11058730 chr11:34937778 PDHX;APIP -0.46 -6.53 -0.34 2.53e-10 Systemic lupus erythematosus and Systemic sclerosis; CRC cis rs9322193 0.886 rs4870055 chr6:150169569 C/T cg05861140 chr6:150128134 PCMT1 -0.42 -7.07 -0.36 9.33e-12 Lung cancer; CRC cis rs1448094 0.967 rs6539934 chr12:86343973 G/A cg18827107 chr12:86230957 RASSF9 -0.38 -6.2 -0.32 1.71e-9 Major depressive disorder; CRC cis rs1005277 0.579 rs2472174 chr10:38375382 A/G cg25517755 chr10:38738941 LOC399744 -0.44 -6.43 -0.33 4.54e-10 Extrinsic epigenetic age acceleration; CRC cis rs172166 0.611 rs203883 chr6:28078356 A/G cg25164649 chr6:28176230 NA 0.64 8.97 0.44 2.29e-17 Cardiac Troponin-T levels; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg24892074 chr4:89444835 PIGY 0.43 6.27 0.33 1.11e-9 Intelligence (multi-trait analysis); CRC cis rs1046896 0.520 rs9895409 chr17:80902719 C/T cg19046167 chr17:80928561 B3GNTL1 0.51 7.33 0.37 1.82e-12 Glycated hemoglobin levels; CRC cis rs1707322 0.963 rs12076580 chr1:46258159 G/A cg06784218 chr1:46089804 CCDC17 0.59 10.38 0.5 4.93e-22 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs3764400 0.508 rs757353 chr17:46122270 A/G cg10706073 chr17:46328419 SKAP1 -0.68 -7.29 -0.37 2.26e-12 Body mass index; CRC cis rs11758351 1.000 rs111596617 chr6:26191678 A/T cg22723502 chr6:26240528 HIST1H4F -0.38 -5.83 -0.31 1.35e-8 Gout;Renal underexcretion gout; CRC cis rs9837602 0.529 rs1087198 chr3:99524381 C/T cg08350549 chr3:99591722 C3orf26;FILIP1L;MIR548G -0.38 -5.87 -0.31 1.05e-8 Breast cancer; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg00251738 chr7:77428046 PHTF2;TMEM60 0.48 6.72 0.35 8.04e-11 Response to antipsychotic treatment; CRC cis rs7666738 0.830 rs10014986 chr4:99000687 A/C cg17366294 chr4:99064904 C4orf37 0.44 7.39 0.38 1.19e-12 Colonoscopy-negative controls vs population controls; CRC cis rs72634258 0.503 rs707457 chr1:7831064 C/A cg26816564 chr1:7831052 VAMP3 0.89 10.1 0.49 4.57e-21 Inflammatory bowel disease; CRC cis rs13427251 0.868 rs1901284 chr2:100146040 A/G cg14399236 chr2:99771627 LIPT1;TSGA10 0.49 7.22 0.37 3.73e-12 Chronic sinus infection; CRC trans rs9858542 1.000 rs4283605 chr3:49678651 A/G cg21665057 chr3:196295764 WDR53;FBXO45 -0.68 -8.97 -0.44 2.29e-17 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs9311474 0.629 rs11709284 chr3:52559705 G/A cg05573699 chr3:52720067 GNL3;PBRM1 -0.44 -6.71 -0.35 8.46e-11 Electroencephalogram traits; CRC cis rs6121246 0.909 rs6058450 chr20:30343911 G/A cg13852791 chr20:30311386 BCL2L1 0.69 10.77 0.51 2.2e-23 Mean corpuscular hemoglobin; CRC cis rs728616 1.000 rs12414891 chr10:81690385 G/C cg05935833 chr10:81318306 SFTPA2 -0.72 -8.19 -0.41 5.66e-15 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs6867913 0.951 rs4912799 chr5:141453720 G/C cg23435118 chr5:141488016 NDFIP1 0.42 5.81 0.31 1.47e-8 Asthma; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg17967426 chr5:168006763 PANK3 0.43 6.27 0.33 1.11e-9 Intelligence (multi-trait analysis); CRC cis rs6951245 1.000 rs75488469 chr7:1102122 A/G cg20603222 chr7:1096387 C7orf50;GPR146 -0.7 -8.43 -0.42 1.1e-15 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs2153535 0.580 rs9406170 chr6:8514153 T/C cg21535247 chr6:8435926 SLC35B3 0.48 7.31 0.37 2.09e-12 Motion sickness; CRC cis rs96067 0.711 rs272827 chr1:36627191 C/T cg25304816 chr1:36627734 MAP7D1 -0.48 -7.32 -0.37 1.91e-12 Corneal structure; CRC cis rs270601 0.683 rs81598 chr5:131587960 C/G cg04518342 chr5:131593106 PDLIM4 0.54 9.05 0.45 1.24e-17 Acylcarnitine levels; CRC cis rs995000 0.931 rs638305 chr1:62906537 G/T cg19896129 chr1:63156450 NA 0.44 6.84 0.35 3.76e-11 Triglyceride levels; CRC cis rs6598955 0.671 rs11247884 chr1:26577338 C/T cg04990556 chr1:26633338 UBXN11 0.56 6.02 0.32 4.53e-9 Obesity-related traits; CRC cis rs60871478 0.636 rs4719520 chr7:875216 C/G cg13844804 chr7:814759 HEATR2 -0.57 -6.07 -0.32 3.62e-9 Cerebrospinal P-tau181p levels; CRC cis rs4731207 0.596 rs10252798 chr7:124637211 A/G cg23710748 chr7:124431027 NA -0.39 -6.18 -0.32 1.87e-9 Cutaneous malignant melanoma; CRC cis rs919433 0.963 rs1896854 chr2:198147776 G/T cg03934865 chr2:198174659 NA -0.43 -7.63 -0.39 2.64e-13 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC trans rs12541902 0.696 rs4299991 chr8:60641321 G/T cg07441319 chr10:8117467 NA 0.38 6.09 0.32 3.2e-9 Obesity-related traits; CRC cis rs9911578 0.935 rs2567912 chr17:56731270 T/C cg12560992 chr17:57184187 TRIM37 0.9 16.15 0.67 1.25e-43 Intelligence (multi-trait analysis); CRC cis rs4243830 0.522 rs10864614 chr1:6596008 G/A cg15205204 chr1:6545172 PLEKHG5 0.38 5.63 0.3 3.81e-8 Body mass index; CRC cis rs7503807 0.967 rs7215486 chr17:78612034 C/T cg09596252 chr17:78655493 RPTOR 0.39 6.09 0.32 3.2e-9 Obesity; CRC cis rs6499255 1.000 rs12446201 chr16:69815586 T/C cg04110750 chr16:69646130 NFAT5 -0.49 -6.5 -0.34 2.99e-10 IgE levels; CRC cis rs7917772 0.636 rs7894154 chr10:104524647 G/A cg22532475 chr10:104410764 TRIM8 0.33 5.62 0.3 4e-8 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC cis rs9549328 0.614 rs34306822 chr13:113616499 G/A cg20742385 chr13:113633654 MCF2L 0.55 9.39 0.46 1.01e-18 Systolic blood pressure; CRC cis rs7914558 0.966 rs10748836 chr10:104693917 G/A cg04362960 chr10:104952993 NT5C2 0.61 9.23 0.45 3.48e-18 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs1387259 0.790 rs2732445 chr12:48645533 C/T cg24011408 chr12:48396354 COL2A1 0.48 6.62 0.34 1.44e-10 Obstructive sleep apnea trait (apnea hypopnea index); CRC cis rs6543140 0.964 rs4851589 chr2:103077145 A/G cg09003973 chr2:102972529 NA 0.41 5.96 0.31 6.62e-9 Blood protein levels; CRC cis rs11608355 0.532 rs7968387 chr12:109788019 A/C cg19025524 chr12:109796872 NA -0.5 -7.97 -0.4 2.68e-14 Neuroticism; CRC cis rs10504229 0.679 rs11783963 chr8:58130496 T/A cg04204079 chr8:58130323 NA -0.45 -5.78 -0.3 1.71e-8 Developmental language disorder (linguistic errors); CRC cis rs9649213 0.593 rs6465667 chr7:97957885 G/A cg24562669 chr7:97807699 LMTK2 0.44 7.29 0.37 2.33e-12 Prostate cancer (SNP x SNP interaction); CRC cis rs11650494 0.908 rs11658111 chr17:47383994 C/T cg08112188 chr17:47440006 ZNF652 1.06 10.0 0.48 1.01e-20 Prostate cancer; CRC cis rs4665809 1.000 rs17040322 chr2:26351274 G/C cg27170947 chr2:26402098 FAM59B -0.46 -6.1 -0.32 2.93e-9 Gut microbiome composition (summer); CRC cis rs9430161 0.579 rs7542158 chr1:11040193 G/A cg02454025 chr1:11042201 C1orf127 0.9 14.49 0.62 3.98e-37 Ewing sarcoma; CRC cis rs6088580 0.634 rs4911420 chr20:32998654 A/G cg24642439 chr20:33292090 TP53INP2 -0.37 -6.34 -0.33 7.66e-10 Glomerular filtration rate (creatinine); CRC cis rs2836950 0.565 rs7279497 chr21:40531306 A/G cg17971929 chr21:40555470 PSMG1 0.58 8.55 0.43 4.6e-16 Menarche (age at onset); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg11094694 chr3:38206939 OXSR1 0.45 6.61 0.34 1.57e-10 Intelligence (multi-trait analysis); CRC cis rs9660992 0.539 rs113699533 chr1:205122895 G/A cg00857998 chr1:205179979 DSTYK 0.47 6.4 0.33 5.21e-10 Mean corpuscular volume;Mean platelet volume; CRC cis rs8180040 0.620 rs6767907 chr3:47162661 C/T cg02527881 chr3:46936655 PTH1R 0.33 5.71 0.3 2.51e-8 Colorectal cancer; CRC cis rs2573652 0.722 rs12914189 chr15:100544429 A/T cg00587665 chr15:100533223 ADAMTS17 0.34 6.01 0.31 4.8e-9 Height; CRC cis rs3741404 0.825 rs2845597 chr11:63954370 G/A cg18225595 chr11:63971243 STIP1 0.64 10.88 0.51 9.41e-24 Platelet count; CRC cis rs875971 0.862 rs10274883 chr7:66116091 C/T cg18876405 chr7:65276391 NA -0.5 -8.05 -0.41 1.5e-14 Aortic root size; CRC cis rs7072216 0.843 rs2296441 chr10:100144782 C/T cg26618903 chr10:100175079 PYROXD2 -0.38 -5.93 -0.31 7.55e-9 Metabolite levels; CRC trans rs877282 0.898 rs12354872 chr10:763362 G/A cg22713356 chr15:30763199 NA 1.28 15.26 0.64 3.9e-40 Uric acid levels; CRC cis rs9807989 0.811 rs4485584 chr2:102970750 T/C cg03938978 chr2:103052716 IL18RAP 0.37 5.97 0.31 6.2e-9 Asthma; CRC cis rs2404602 0.647 rs7181506 chr15:76935677 G/T cg23625390 chr15:77176239 SCAPER 0.89 13.9 0.61 7.07e-35 Blood metabolite levels; CRC cis rs6684514 0.961 rs12048077 chr1:156299916 T/A cg16558208 chr1:156270281 VHLL 0.56 8.76 0.43 1.06e-16 Mean corpuscular hemoglobin concentration;Glycated hemoglobin levels; CRC cis rs4319547 0.774 rs7959238 chr12:123131498 A/T cg05707623 chr12:122985044 ZCCHC8 -0.62 -8.03 -0.4 1.77e-14 Body mass index; CRC cis rs1832871 0.672 rs9457344 chr6:158742043 C/T cg07165851 chr6:158734300 TULP4 0.63 7.96 0.4 2.75e-14 Height; CRC cis rs6502050 0.805 rs62078303 chr17:80085210 A/G cg13198984 chr17:80129470 CCDC57 -0.48 -8.56 -0.43 4.49e-16 Life satisfaction; CRC cis rs4481887 1.000 rs10788782 chr1:248496132 C/A cg13385794 chr1:248469461 NA 0.39 6.68 0.35 9.97e-11 Common traits (Other); CRC cis rs8103278 0.507 rs4802276 chr19:46260748 T/C cg02376097 chr19:46275166 DMPK 0.37 5.83 0.31 1.33e-8 Coronary artery disease; CRC cis rs116095464 0.558 rs10079760 chr5:230778 A/G cg22496380 chr5:211416 CCDC127 -0.78 -9.24 -0.45 3.09e-18 Breast cancer; CRC cis rs7020830 0.898 rs13289199 chr9:37278064 A/T cg14294708 chr9:37120828 ZCCHC7 1.12 23.97 0.8 3.83e-74 Schizophrenia; CRC cis rs4731207 0.565 rs1994025 chr7:124663859 A/G cg23710748 chr7:124431027 NA -0.39 -6.11 -0.32 2.87e-9 Cutaneous malignant melanoma; CRC cis rs9435341 0.965 rs1335053 chr1:107622823 C/T cg15468180 chr1:107600409 PRMT6 -0.42 -6.29 -0.33 9.93e-10 Facial morphology (factor 21, depth of nasal alae); CRC cis rs7120118 0.517 rs56168519 chr11:47317987 T/C cg25783544 chr11:47291846 MADD 0.62 5.71 0.3 2.47e-8 HDL cholesterol; CRC cis rs13108904 0.875 rs1732099 chr4:1282696 T/C cg23123621 chr4:1343375 KIAA1530 -0.36 -6.72 -0.35 8.11e-11 Obesity-related traits; CRC cis rs992157 0.710 rs56364928 chr2:219059058 G/A cg04731861 chr2:219085781 ARPC2 -0.29 -6.15 -0.32 2.27e-9 Colorectal cancer; CRC cis rs300703 0.542 rs300696 chr2:183330 G/A cg21211680 chr2:198530 NA -0.74 -9.02 -0.45 1.64e-17 Blood protein levels; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg03057164 chr11:17099458 RPS13 0.44 6.14 0.32 2.31e-9 Response to antipsychotic treatment; CRC cis rs4594175 0.926 rs72688717 chr14:51614493 C/T cg23942311 chr14:51606299 NA 0.64 9.62 0.47 1.81e-19 Cancer; CRC cis rs4713118 0.516 rs7739216 chr6:28079946 G/T cg25164649 chr6:28176230 NA 0.77 9.45 0.46 6.39e-19 Parkinson's disease; CRC cis rs561341 1.000 rs501957 chr17:30314504 C/T cg23018236 chr17:30244563 NA -0.66 -7.99 -0.4 2.32e-14 Hip circumference adjusted for BMI; CRC cis rs5750830 0.649 rs5750815 chr22:39798449 T/C cg24399712 chr22:39784796 NA -0.48 -9.12 -0.45 7.58e-18 Intelligence (multi-trait analysis); CRC cis rs11764590 0.715 rs56289396 chr7:2091415 G/A cg25834613 chr7:1915315 MAD1L1 -0.42 -5.94 -0.31 7.09e-9 Neuroticism; CRC trans rs11098499 0.619 rs28502463 chr4:120257023 T/C cg25214090 chr10:38739885 LOC399744 0.54 8.5 0.42 6.89e-16 Corneal astigmatism; CRC cis rs7762018 1.000 rs6912959 chr6:170126224 G/A cg19338460 chr6:170058176 WDR27 -0.67 -7.38 -0.38 1.32e-12 Thiazide-induced adverse metabolic effects in hypertensive patients; CRC cis rs951366 0.617 rs823074 chr1:205774839 T/C cg24503407 chr1:205819492 PM20D1 1.02 18.4 0.71 1.8e-52 Menarche (age at onset); CRC cis rs11758351 0.587 rs16891466 chr6:26235737 G/A cg01420254 chr6:26195488 NA 0.72 7.75 0.39 1.18e-13 Gout;Renal underexcretion gout; CRC cis rs9326248 1.000 rs664922 chr11:117070895 C/A cg26566898 chr11:117069891 TAGLN 0.45 9.66 0.47 1.31e-19 Blood protein levels; CRC cis rs751728 1.000 rs1359781 chr6:33762104 T/C cg25922239 chr6:33757077 LEMD2 0.61 9.68 0.47 1.12e-19 Crohn's disease; CRC cis rs2840044 1.000 rs7212704 chr17:33898897 C/T cg05299278 chr17:33885742 SLFN14 -0.41 -6.24 -0.33 1.33e-9 Response to radiotherapy in cancer (late toxicity); CRC cis rs4819852 0.958 rs2238784 chr22:19972559 G/A cg07821417 chr22:19972146 ARVCF 0.44 5.98 0.31 5.96e-9 Pulse pressure; CRC cis rs881375 0.967 rs7875829 chr9:123660398 A/G cg00246817 chr9:123691163 NA -0.47 -6.0 -0.31 5.19e-9 Rheumatoid arthritis; CRC cis rs6662572 0.737 rs11587648 chr1:46585418 G/A cg03123370 chr1:45965343 CCDC163P;MMACHC 0.47 6.3 0.33 9.58e-10 Blood protein levels; CRC cis rs7849270 1.000 rs7036236 chr9:131899299 G/A cg13538475 chr9:131942899 NA -0.32 -6.36 -0.33 6.65e-10 Blood metabolite ratios; CRC cis rs12692738 0.526 rs355850 chr2:165626043 C/T cg03182029 chr2:165697222 COBLL1 0.51 6.07 0.32 3.46e-9 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);Waist-to-hip ratio adjusted for BMI in non-smokers;Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction);Waist-to-hip ratio adjusted for body mass index; CRC cis rs4713118 0.662 rs149970 chr6:27980220 C/T cg12273811 chr6:28175739 NA 0.64 8.85 0.44 5.61e-17 Parkinson's disease; CRC cis rs10504229 0.775 rs17805110 chr8:58161439 C/G cg21724239 chr8:58056113 NA -0.62 -8.24 -0.41 4.02e-15 Developmental language disorder (linguistic errors); CRC cis rs9322193 0.923 rs2342857 chr6:150130673 G/A cg07701084 chr6:150067640 NUP43 0.48 6.78 0.35 5.71e-11 Lung cancer; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg11256290 chr10:32734912 CCDC7 0.41 6.64 0.34 1.3e-10 Intelligence (multi-trait analysis); CRC trans rs1814175 0.754 rs10219245 chr11:49645052 C/T cg03929089 chr4:120376271 NA -0.94 -17.71 -0.7 8.92e-50 Height; CRC cis rs1008375 0.933 rs6847966 chr4:17634255 G/A cg02297831 chr4:17616191 MED28 0.48 6.44 0.33 4.31e-10 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs727563 0.580 rs202626 chr22:41847190 C/A cg06481639 chr22:41940642 POLR3H 0.47 5.82 0.31 1.42e-8 Crohn's disease;Inflammatory bowel disease; CRC cis rs5753618 0.509 rs2079431 chr22:31564334 C/T cg22777020 chr22:31556080 RNF185 -0.51 -5.93 -0.31 7.76e-9 Colorectal cancer; CRC cis rs4319547 0.656 rs10744209 chr12:122931568 G/A cg05707623 chr12:122985044 ZCCHC8 -0.75 -9.27 -0.46 2.46e-18 Body mass index; CRC cis rs514406 0.505 rs374849 chr1:53185631 G/A cg24675658 chr1:53192096 ZYG11B -0.67 -10.16 -0.49 2.85e-21 Monocyte count; CRC trans rs875971 0.660 rs2191268 chr7:66110224 C/T cg16717773 chr1:155211079 GBA -0.39 -5.99 -0.31 5.48e-9 Aortic root size; CRC trans rs1728785 1.000 rs1170426 chr16:68603798 C/T cg04657470 chr2:198365150 HSPE1;HSPD1 0.59 7.14 0.37 6.11e-12 Ulcerative colitis; CRC trans rs11039798 0.698 rs6485805 chr11:48101723 C/T cg15704280 chr7:45808275 SEPT13 0.67 6.0 0.31 5.12e-9 Axial length; CRC cis rs2797160 1.000 rs1832980 chr6:125997444 T/G cg05901451 chr6:126070800 HEY2 -0.38 -5.96 -0.31 6.39e-9 Endometrial cancer; CRC cis rs11190604 0.767 rs7916904 chr10:102186778 C/G cg16342193 chr10:102329863 NA -0.33 -5.62 -0.3 4.16e-8 Palmitoleic acid (16:1n-7) levels; CRC cis rs736408 0.570 rs11130327 chr3:52793239 A/G cg15147215 chr3:52552868 STAB1 -0.62 -10.07 -0.49 5.58e-21 Bipolar disorder; CRC cis rs853679 1.000 rs1419183 chr6:28242794 A/C cg15786705 chr6:28176104 NA 0.59 6.05 0.32 3.84e-9 Depression; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg11614622 chr11:66623681 LRFN4;PC 0.47 7.37 0.38 1.37e-12 Intelligence (multi-trait analysis); CRC cis rs10486722 0.638 rs10951659 chr7:41792345 T/G cg22138096 chr7:41772439 LOC285954 0.45 5.68 0.3 2.97e-8 Pit-and-Fissure caries; CRC cis rs10504229 0.728 rs72650852 chr8:58150463 G/A cg02290350 chr8:58132656 NA -0.55 -6.73 -0.35 7.4e-11 Developmental language disorder (linguistic errors); CRC cis rs7584330 0.518 rs7585969 chr2:238439073 G/A cg08992911 chr2:238395768 MLPH 0.59 6.11 0.32 2.82e-9 Prostate cancer; CRC cis rs796364 0.906 rs281766 chr2:200820505 T/G cg12253985 chr2:200820533 C2orf60;C2orf47 0.61 6.54 0.34 2.36e-10 Schizophrenia; CRC cis rs951366 0.873 rs823118 chr1:205723572 C/T cg07167872 chr1:205819463 PM20D1 0.46 6.84 0.35 3.94e-11 Menarche (age at onset); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg21866054 chr4:103748674 UBE2D3 0.45 6.4 0.33 5.27e-10 Response to antipsychotic treatment; CRC trans rs12663356 0.528 rs9350359 chr6:21462624 C/T cg16924120 chr12:118814149 SUDS3 0.4 6.02 0.31 4.57e-9 Crohn's disease; CRC cis rs10540 1.000 rs71487292 chr11:486076 G/A cg08200582 chr11:442649 ANO9 -0.68 -6.42 -0.33 4.65e-10 Body mass index; CRC cis rs1153858 0.943 rs4774580 chr15:45652086 G/A cg14582100 chr15:45693742 SPATA5L1 0.3 6.17 0.32 2.01e-9 Homoarginine levels; CRC cis rs62064224 0.589 rs756785 chr17:30812845 T/C cg25809561 chr17:30822961 MYO1D 0.57 10.52 0.5 1.65e-22 Schizophrenia; CRC cis rs11190604 1.000 rs2489040 chr10:102331298 G/A cg07080220 chr10:102295463 HIF1AN 0.45 5.69 0.3 2.8e-8 Palmitoleic acid (16:1n-7) levels; CRC cis rs10779751 1.000 rs2300093 chr1:11266392 G/C cg08854313 chr1:11322531 MTOR 0.77 12.05 0.55 6.12e-28 Body mass index; CRC cis rs34779708 0.931 rs4007289 chr10:35269790 G/A cg03585969 chr10:35415529 CREM 0.59 8.04 0.41 1.68e-14 Inflammatory bowel disease;Crohn's disease; CRC cis rs13108904 0.870 rs1960426 chr4:1274365 C/T cg05665937 chr4:1216051 CTBP1 0.4 6.04 0.32 4.1e-9 Obesity-related traits; CRC cis rs262150 0.659 rs2657340 chr7:158796968 C/T cg12590608 chr7:158785262 NA -0.33 -5.7 -0.3 2.73e-8 Facial morphology (factor 20); CRC cis rs1129187 0.755 rs9471985 chr6:42941324 T/C cg00597713 chr6:42947103 PEX6 -0.42 -5.92 -0.31 7.89e-9 Alzheimer's disease in APOE e4+ carriers; CRC cis rs6460942 0.591 rs62451465 chr7:12364585 A/G cg06484146 chr7:12443880 VWDE -0.58 -6.47 -0.34 3.6e-10 Coronary artery disease; CRC cis rs909674 0.818 rs5757680 chr22:39844793 C/T cg11247378 chr22:39784982 NA 0.37 6.79 0.35 5.18e-11 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; CRC cis rs4713118 0.955 rs34752872 chr6:27683244 A/T cg03623178 chr6:28175578 NA 0.64 8.29 0.42 2.88e-15 Parkinson's disease; CRC cis rs12477438 0.798 rs972768 chr2:99682397 G/C cg14399236 chr2:99771627 LIPT1;TSGA10 -0.74 -10.37 -0.5 5.51e-22 Chronic sinus infection; CRC cis rs1760803 0.754 rs10158820 chr1:154217763 C/T cg26808167 chr1:154192205 UBAP2L;C1orf43 -0.34 -5.94 -0.31 7.2e-9 Nicotine dependence; CRC cis rs951366 0.617 rs823075 chr1:205774897 C/T cg07157834 chr1:205819609 PM20D1 0.97 16.82 0.68 2.99e-46 Menarche (age at onset); CRC cis rs9549367 0.713 rs3024764 chr13:113824314 A/G cg18105134 chr13:113819100 PROZ -0.86 -13.22 -0.59 2.6e-32 Platelet distribution width; CRC cis rs2228479 0.717 rs2270460 chr16:89972416 C/A cg06558623 chr16:89946397 TCF25 0.88 9.76 0.47 6.36e-20 Skin colour saturation; CRC cis rs4889855 0.556 rs4890039 chr17:78517883 C/T cg16591659 chr17:78472290 NA 0.42 6.04 0.32 4.07e-9 Fractional excretion of uric acid; CRC cis rs7726839 0.540 rs12520279 chr5:657291 T/C cg09021430 chr5:549028 NA -0.72 -8.15 -0.41 7.69e-15 Obesity-related traits; CRC cis rs77633900 0.772 rs284905 chr15:76743345 C/T cg21673338 chr15:77095150 SCAPER -0.7 -6.06 -0.32 3.79e-9 Non-glioblastoma glioma;Glioma; CRC cis rs477895 0.713 rs1059440 chr11:63991801 C/T cg23719950 chr11:63933701 MACROD1 0.67 8.53 0.43 5.51e-16 Mean platelet volume; CRC cis rs4363385 0.818 rs561143 chr1:153010734 C/T cg25856811 chr1:152973957 SPRR3 -0.25 -6.99 -0.36 1.51e-11 Inflammatory skin disease; CRC cis rs10461617 0.531 rs2662033 chr5:56213410 T/G cg20203395 chr5:56204925 C5orf35 -0.68 -8.34 -0.42 2.04e-15 Type 2 diabetes; CRC cis rs7258465 0.965 rs2561043 chr19:18622683 A/T cg10790698 chr19:18539756 SSBP4 -0.46 -8.96 -0.44 2.49e-17 Breast cancer; CRC cis rs9291683 0.620 rs717615 chr4:10104670 C/T cg11266682 chr4:10021025 SLC2A9 0.43 8.77 0.44 9.87e-17 Bone mineral density; CRC cis rs798554 1.000 rs798536 chr7:2766383 G/A cg19346786 chr7:2764209 NA -0.42 -7.36 -0.38 1.51e-12 Height; CRC cis rs172166 0.769 rs149965 chr6:28018689 T/A cg20615401 chr6:28092323 ZSCAN16 0.46 6.19 0.32 1.75e-9 Cardiac Troponin-T levels; CRC cis rs4731207 0.564 rs10234592 chr7:124611656 A/G cg23710748 chr7:124431027 NA -0.39 -6.25 -0.33 1.29e-9 Cutaneous malignant melanoma; CRC cis rs12681287 0.546 rs11539113 chr8:87497176 G/A cg27223183 chr8:87520930 FAM82B -0.51 -7.34 -0.38 1.67e-12 Caudate activity during reward; CRC trans rs8002861 0.905 rs9525869 chr13:44467210 A/G cg17145862 chr1:211918768 LPGAT1 0.78 15.75 0.66 4.75e-42 Leprosy; CRC trans rs66573146 0.561 rs67245546 chr4:6947164 T/C cg07817883 chr1:32538562 TMEM39B 1.24 12.08 0.55 4.79e-28 Granulocyte percentage of myeloid white cells; CRC cis rs8072100 0.790 rs7222225 chr17:45693497 A/G cg25173405 chr17:45401733 C17orf57 0.39 5.81 0.3 1.5e-8 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs10504229 1.000 rs67236942 chr8:58176525 T/C cg05313129 chr8:58192883 C8orf71 -0.47 -6.99 -0.36 1.49e-11 Developmental language disorder (linguistic errors); CRC cis rs9303401 0.614 rs34683543 chr17:56520036 C/A cg02118635 chr17:56770003 RAD51C;TEX14 0.72 9.17 0.45 5.19e-18 Cognitive test performance; CRC trans rs12200782 0.510 rs9467738 chr6:26382181 T/C cg25800765 chr12:85673347 ALX1 0.26 5.96 0.31 6.54e-9 Small cell lung carcinoma; CRC cis rs1465370 0.711 rs4731689 chr7:130009839 C/T cg03229158 chr7:130009420 NA 0.49 6.88 0.35 3.01e-11 Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction);Waist circumference adjusted for BMI in active individuals;Waist circumference adjusted for body mass index; CRC cis rs896854 0.846 rs7845219 chr8:95937502 T/C cg13393036 chr8:95962371 TP53INP1 -0.51 -8.4 -0.42 1.32e-15 Type 2 diabetes; CRC cis rs6062302 0.522 rs2297428 chr20:62221766 C/T cg09650180 chr20:62225654 GMEB2 -0.5 -6.7 -0.35 9.27e-11 Glioblastoma; CRC cis rs908922 0.676 rs7530609 chr1:152526812 C/A cg23254163 chr1:152506842 NA 0.45 9.13 0.45 6.92e-18 Hair morphology; CRC cis rs12940626 0.674 rs11867297 chr17:66433493 C/T cg02501334 chr17:66508232 PRKAR1A 0.4 5.62 0.3 4.06e-8 Red cell distribution width; CRC cis rs10504229 0.679 rs11781858 chr8:58038406 C/T cg22535103 chr8:58192502 C8orf71 -0.72 -7.88 -0.4 4.8e-14 Developmental language disorder (linguistic errors); CRC cis rs853679 0.517 rs9380047 chr6:28037893 G/T cg25164649 chr6:28176230 NA 0.73 9.16 0.45 5.49e-18 Depression; CRC cis rs12620999 0.941 rs13005377 chr2:238037759 T/C cg23555395 chr2:238036564 NA -0.63 -9.93 -0.48 1.71e-20 Systemic lupus erythematosus; CRC cis rs73206853 0.841 rs17625767 chr12:111102627 A/C cg12870014 chr12:110450643 ANKRD13A 0.69 6.82 0.35 4.41e-11 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC cis rs12900413 0.562 rs28557101 chr15:90298149 C/T cg24249390 chr15:90295951 MESP1 -0.62 -9.76 -0.47 6.44e-20 Coronary artery aneurysm in Kawasaki disease; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg21768436 chr8:67341108 RRS1 0.35 6.04 0.32 4.15e-9 Liver disease severity in Alagille syndrome; CRC cis rs736408 0.812 rs4687654 chr3:52827566 G/A cg18404041 chr3:52824283 ITIH1 -0.53 -10.83 -0.51 1.43e-23 Bipolar disorder; CRC cis rs3091242 0.934 rs686631 chr1:25719599 A/T cg27572855 chr1:25598939 RHD 0.32 5.69 0.3 2.78e-8 Erythrocyte sedimentation rate; CRC cis rs1129187 0.967 rs3805951 chr6:42937176 C/A cg09436375 chr6:42928200 GNMT -0.32 -5.77 -0.3 1.86e-8 Alzheimer's disease in APOE e4+ carriers; CRC cis rs6582630 0.524 rs10785494 chr12:38532431 C/G cg13010199 chr12:38710504 ALG10B -0.42 -6.07 -0.32 3.55e-9 Drug-induced liver injury (flucloxacillin); CRC cis rs6120849 0.707 rs6120826 chr20:33671831 G/A cg08999081 chr20:33150536 PIGU 0.44 5.71 0.3 2.52e-8 Protein C levels; CRC cis rs1552244 1.000 rs9849434 chr3:10133710 A/G cg10729496 chr3:10149963 C3orf24 -0.49 -6.61 -0.34 1.57e-10 Alzheimer's disease; CRC cis rs2985684 0.948 rs4900925 chr14:50012325 A/G cg04989706 chr14:50066350 PPIL5 0.53 7.05 0.36 1.04e-11 Carotid intima media thickness; CRC cis rs7772486 0.738 rs2246334 chr6:146183635 G/A cg13319975 chr6:146136371 FBXO30 -0.46 -6.96 -0.36 1.83e-11 Lobe attachment (rater-scored or self-reported); CRC cis rs2050392 0.929 rs10826798 chr10:30700904 G/A cg25182066 chr10:30743637 MAP3K8 0.39 5.77 0.3 1.8e-8 Inflammatory bowel disease; CRC cis rs60843830 1.000 rs4497901 chr2:239969 C/T cg25945732 chr2:264204 ACP1;SH3YL1 0.72 12.02 0.55 7.97e-28 Spherical equivalent (joint analysis main effects and education interaction); CRC trans rs1814175 0.645 rs847635 chr11:49923323 G/A cg03929089 chr4:120376271 NA -0.91 -16.07 -0.66 2.65e-43 Height; CRC cis rs10751667 0.666 rs10902235 chr11:938892 T/C cg01483505 chr11:975446 AP2A2 0.44 7.24 0.37 3.16e-12 Alzheimer's disease (late onset); CRC cis rs4713118 0.955 rs9393847 chr6:27687973 G/A cg19041857 chr6:27730383 NA -0.44 -6.08 -0.32 3.38e-9 Parkinson's disease; CRC cis rs798554 0.757 rs1713919 chr7:2864706 C/A cg19346786 chr7:2764209 NA -0.42 -7.19 -0.37 4.51e-12 Height; CRC cis rs3106136 0.837 rs2289186 chr4:95255637 T/G cg11021082 chr4:95130006 SMARCAD1 0.43 6.47 0.34 3.58e-10 Capecitabine sensitivity; CRC cis rs9527 0.590 rs10509766 chr10:104926334 T/C cg04362960 chr10:104952993 NT5C2 0.61 8.4 0.42 1.37e-15 Arsenic metabolism; CRC cis rs7605378 0.658 rs4673507 chr2:200710167 G/C cg17644776 chr2:200775616 C2orf69 0.5 7.68 0.39 1.88e-13 Osteoporosis; CRC cis rs2361718 0.500 rs12451697 chr17:78100690 T/A cg14949292 chr17:78079608 GAA -0.43 -6.15 -0.32 2.23e-9 Yeast infection; CRC cis rs7618501 0.633 rs9814664 chr3:50078541 C/T cg24110177 chr3:50126178 RBM5 0.52 8.07 0.41 1.35e-14 Intelligence (multi-trait analysis); CRC cis rs6743376 0.556 rs1530550 chr2:113817513 A/T cg24553058 chr2:113831203 IL1F10 0.43 7.0 0.36 1.47e-11 Inflammatory biomarkers; CRC trans rs67073037 0.955 rs4666141 chr2:29164022 G/T cg13899017 chr1:159158444 CADM3 -0.37 -6.17 -0.32 1.98e-9 Breast cancer;Breast cancer (estrogen-receptor negative); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg22159483 chr17:1588198 PRPF8 0.43 6.04 0.32 4.26e-9 Response to antipsychotic treatment; CRC cis rs6484504 0.532 rs7121949 chr11:31288160 G/T cg14844989 chr11:31128820 NA -0.34 -5.97 -0.31 6.13e-9 Red blood cell count; CRC cis rs6089584 0.606 rs6089599 chr20:60576992 A/G cg23262073 chr20:60523788 NA 0.4 7.04 0.36 1.15e-11 Body mass index; CRC cis rs10486722 0.606 rs10807910 chr7:41796992 A/G cg22138096 chr7:41772439 LOC285954 0.45 5.64 0.3 3.67e-8 Pit-and-Fissure caries; CRC cis rs2115630 0.653 rs61394864 chr15:85170174 T/C cg12501888 chr15:85177176 SCAND2 -0.49 -8.38 -0.42 1.59e-15 P wave terminal force; CRC cis rs9467711 0.591 rs34791189 chr6:26035806 G/A cg08501292 chr6:25962987 TRIM38 0.84 8.08 0.41 1.25e-14 Autism spectrum disorder or schizophrenia; CRC cis rs1395 0.744 rs62130714 chr2:27532870 A/G cg23587288 chr2:27483067 SLC30A3 -0.42 -6.08 -0.32 3.37e-9 Blood metabolite levels; CRC cis rs6840360 1.000 rs6833368 chr4:152603177 C/T cg09659197 chr4:152720779 NA -0.51 -11.19 -0.53 7.49e-25 Intelligence (multi-trait analysis); CRC cis rs1799949 0.896 rs33933393 chr17:41317432 C/T cg01879757 chr17:41196368 BRCA1 -0.43 -6.59 -0.34 1.79e-10 Menopause (age at onset); CRC cis rs2652834 1.000 rs2134265 chr15:63398196 G/A cg05507819 chr15:63340323 TPM1 0.47 5.98 0.31 5.87e-9 HDL cholesterol; CRC cis rs7113874 0.589 rs7939731 chr11:8510299 T/G cg02811074 chr11:8615871 STK33 -0.36 -6.17 -0.32 1.95e-9 Body mass index in physically active individuals;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs801193 1.000 rs6975195 chr7:66124774 T/A cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.44 -6.46 -0.34 3.75e-10 Aortic root size; CRC cis rs4713118 0.868 rs742047 chr6:27739380 A/G cg12172441 chr6:28176163 NA 0.6 6.59 0.34 1.71e-10 Parkinson's disease; CRC cis rs4290604 0.679 rs4663700 chr2:238036764 T/C cg23555395 chr2:238036564 NA -0.54 -6.94 -0.36 2.14e-11 Asthma; CRC cis rs11098699 0.769 rs13136692 chr4:124229169 G/A cg09941581 chr4:124220074 SPATA5 0.39 5.81 0.3 1.49e-8 Mosquito bite size; CRC cis rs7914558 0.966 rs10786724 chr10:104668942 A/G cg04362960 chr10:104952993 NT5C2 0.61 9.15 0.45 5.95e-18 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs7927771 0.801 rs12798028 chr11:47604639 C/T cg05585544 chr11:47624801 NA -0.46 -8.26 -0.41 3.69e-15 Subjective well-being; CRC cis rs912057 0.833 rs1294418 chr6:6742185 A/G cg06612196 chr6:6737390 NA 0.51 8.2 0.41 5.27e-15 Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction); CRC cis rs11679072 1.000 rs6735368 chr2:240448748 C/T cg03276489 chr2:240449683 NA -0.93 -9.41 -0.46 8.71e-19 Blood pressure (smoking interaction); CRC trans rs7395662 1.000 rs4882132 chr11:48593125 C/T cg21153622 chr11:89784906 NA -0.45 -6.96 -0.36 1.8e-11 HDL cholesterol; CRC cis rs7618915 0.547 rs62253700 chr3:52625019 T/A cg07507251 chr3:52567010 NT5DC2 0.42 6.06 0.32 3.62e-9 Bipolar disorder; CRC trans rs62103177 0.810 rs62096745 chr18:77619135 A/G cg05926928 chr17:57297772 GDPD1 1.09 10.42 0.5 3.56e-22 Opioid sensitivity; CRC cis rs117623576 0.941 rs17230172 chr10:32438490 G/T cg03047570 chr10:32398778 NA -0.69 -6.86 -0.35 3.45e-11 Anti-saccade response; CRC cis rs870825 0.581 rs28602720 chr4:185630598 T/C cg04058563 chr4:185651563 MLF1IP 0.72 9.12 0.45 7.93e-18 Blood protein levels; CRC cis rs10540 1.000 rs12788729 chr11:502371 G/A cg15790184 chr11:494944 RNH1 0.6 6.17 0.32 1.95e-9 Body mass index; CRC cis rs7487075 0.619 rs4768717 chr12:46831561 C/T cg22049899 chr12:47219821 SLC38A4 0.31 5.74 0.3 2.12e-8 Itch intensity from mosquito bite; CRC cis rs9814567 1.000 rs4974493 chr3:134219993 C/T cg06109529 chr3:134205091 CEP63;ANAPC13 -0.81 -12.37 -0.56 4.1e-29 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs4692589 1.000 rs7666219 chr4:170932739 T/C cg19918862 chr4:170955249 NA 0.4 6.53 0.34 2.51e-10 Anxiety disorder; CRC cis rs76793172 0.588 rs8110017 chr19:46289392 G/C cg11657440 chr19:46296263 DMWD 0.58 6.03 0.32 4.52e-9 Eosinophil counts; CRC cis rs3845702 1.000 rs3845697 chr2:180798553 C/T cg23417306 chr2:180868811 CWC22 0.42 5.63 0.3 3.91e-8 Schizophrenia; CRC cis rs12497850 0.897 rs6781790 chr3:49044767 C/T cg20833759 chr3:49053208 WDR6;DALRD3 0.53 9.15 0.45 6.27e-18 Parkinson's disease; CRC cis rs427943 0.750 rs8130224 chr21:46616441 A/G cg19498844 chr21:46707878 POFUT2;LOC642852 0.44 5.97 0.31 6.09e-9 Body mass index; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg02096607 chr11:27493868 LGR4 0.37 7.13 0.37 6.31e-12 Liver disease severity in Alagille syndrome; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg23001456 chr17:2615074 KIAA0664 0.37 5.99 0.31 5.52e-9 Liver disease severity in Alagille syndrome; CRC cis rs2580764 0.565 rs2044291 chr2:55247954 A/G cg09592903 chr2:55203963 RTN4 -0.71 -11.43 -0.53 1.03e-25 Mean platelet volume; CRC cis rs138880 0.542 rs9616215 chr22:50318834 C/T cg08270630 chr22:50330655 NA -0.57 -5.79 -0.3 1.68e-8 Schizophrenia; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg16944159 chr2:62132759 COMMD1 0.5 7.22 0.37 3.74e-12 Response to antipsychotic treatment; CRC cis rs1448094 0.967 rs10863118 chr12:86339232 C/G cg18827107 chr12:86230957 RASSF9 -0.38 -6.25 -0.33 1.3e-9 Major depressive disorder; CRC cis rs9640161 0.789 rs11767409 chr7:150058043 C/T cg12556325 chr7:150026731 C7orf29;LRRC61 -0.41 -5.73 -0.3 2.32e-8 Blood protein levels;Circulating chemerin levels; CRC cis rs13191362 0.507 rs2023036 chr6:163122736 C/T cg21926612 chr6:163149169 PACRG;PARK2 0.61 9.49 0.46 4.72e-19 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs4713118 0.586 rs6905522 chr6:28086479 A/C cg02683197 chr6:28174875 NA 0.85 10.27 0.49 1.16e-21 Parkinson's disease; CRC cis rs7666738 0.962 rs4699596 chr4:99012924 C/T cg05340658 chr4:99064831 C4orf37 0.52 7.39 0.38 1.23e-12 Colonoscopy-negative controls vs population controls; CRC cis rs11650494 0.516 rs13341862 chr17:47494203 A/G cg08112188 chr17:47440006 ZNF652 -0.82 -7.21 -0.37 3.85e-12 Prostate cancer; CRC cis rs2346177 0.554 rs36006825 chr2:46708945 G/T cg26688816 chr2:46740690 ATP6V1E2 -0.62 -9.41 -0.46 8.67e-19 HDL cholesterol; CRC cis rs3820068 0.603 rs72647138 chr1:15980929 C/T cg24675056 chr1:15929824 NA 0.53 7.18 0.37 4.76e-12 Systolic blood pressure; CRC trans rs1728785 1.000 rs698717 chr16:68560199 A/G cg04657470 chr2:198365150 HSPE1;HSPD1 0.75 8.66 0.43 2.18e-16 Ulcerative colitis; CRC cis rs1223397 0.938 rs3817741 chr6:13279507 A/G cg20827128 chr6:13274284 PHACTR1 -0.5 -6.32 -0.33 8.48e-10 Blood pressure; CRC cis rs736408 0.609 rs13095332 chr3:52787242 C/T cg05573699 chr3:52720067 GNL3;PBRM1 -0.44 -6.13 -0.32 2.54e-9 Bipolar disorder; CRC cis rs853679 0.517 rs4713150 chr6:28136212 G/A cg15845792 chr6:28175446 NA 1.04 13.88 0.61 8.66e-35 Depression; CRC cis rs853679 0.517 rs9368553 chr6:28082265 T/C cg18032046 chr6:28092343 ZSCAN16 -0.52 -6.02 -0.31 4.76e-9 Depression; CRC cis rs752010 1.000 rs752010 chr1:42093015 C/T cg06885757 chr1:42089581 HIVEP3 0.49 8.55 0.43 4.65e-16 Lupus nephritis in systemic lupus erythematosus; CRC cis rs1448094 0.512 rs4362214 chr12:86245145 C/T cg25456477 chr12:86230367 RASSF9 0.32 5.67 0.3 3.13e-8 Major depressive disorder; CRC cis rs968567 0.638 rs7943728 chr11:61547068 G/A cg07005513 chr11:61595956 FADS2 -0.5 -6.31 -0.33 9.09e-10 Blood metabolite levels;Rheumatoid arthritis;Vitiligo;Glycerophospholipid levels; CRC cis rs35110281 0.712 rs162345 chr21:44954155 T/G cg01579765 chr21:45077557 HSF2BP -0.37 -6.98 -0.36 1.68e-11 Mean corpuscular volume; CRC cis rs17253792 0.822 rs8006705 chr14:56171283 C/T cg01858014 chr14:56050164 KTN1 -0.72 -6.9 -0.36 2.63e-11 Putamen volume; CRC cis rs79839061 0.611 rs2279183 chr4:882404 T/C cg07828340 chr4:882639 GAK 0.63 6.94 0.36 2.12e-11 Intelligence (multi-trait analysis); CRC cis rs7901135 0.962 rs6481438 chr10:60559603 A/G cg23799393 chr10:60588674 BICC1 0.39 6.0 0.31 5.22e-9 Morning vs. evening chronotype; CRC cis rs17253792 0.822 rs78432811 chr14:56051545 T/C cg01858014 chr14:56050164 KTN1 -0.87 -6.81 -0.35 4.51e-11 Putamen volume; CRC cis rs7727544 0.716 rs72793278 chr5:131561372 C/A cg14196790 chr5:131705035 SLC22A5 0.36 6.2 0.32 1.72e-9 Blood metabolite levels; CRC cis rs11098499 0.754 rs12509621 chr4:120249660 T/C cg09307838 chr4:120376055 NA 0.61 9.59 0.47 2.22e-19 Corneal astigmatism; CRC cis rs7731657 0.538 rs2107335 chr5:130292853 C/A cg08523029 chr5:130500466 HINT1 -0.49 -6.19 -0.32 1.83e-9 Fasting plasma glucose; CRC cis rs11055008 0.935 rs10845601 chr12:12820134 A/G cg04607235 chr12:12878440 APOLD1 0.46 6.02 0.32 4.53e-9 Pulse pressure; CRC cis rs2727020 0.521 rs4980445 chr11:49570183 C/T cg27395922 chr11:50257633 LOC441601 -0.34 -5.6 -0.3 4.52e-8 Coronary artery disease; CRC cis rs11098499 0.908 rs1002152 chr4:120273387 C/A cg24375607 chr4:120327624 NA 0.49 7.44 0.38 8.67e-13 Corneal astigmatism; CRC cis rs801193 1.000 rs6958520 chr7:66151453 T/C cg00343986 chr7:65444356 GUSB 0.49 7.24 0.37 3.15e-12 Aortic root size; CRC cis rs7847628 0.765 rs7026635 chr9:123550027 A/G cg09586646 chr9:123605570 PSMD5;LOC253039 -0.57 -6.71 -0.35 8.67e-11 Birth weight; CRC cis rs2971970 0.519 rs10230628 chr7:133633133 G/A cg03336402 chr7:133662267 EXOC4 0.63 9.63 0.47 1.65e-19 Intelligence (multi-trait analysis); CRC cis rs2880765 0.546 rs35316253 chr15:86065560 T/C cg10818794 chr15:86012489 AKAP13 -0.45 -6.54 -0.34 2.39e-10 Coronary artery disease; CRC cis rs75422866 0.510 rs35784744 chr12:48123429 T/G cg14736327 chr12:48174669 SLC48A1 -0.75 -6.17 -0.32 1.99e-9 Pneumonia; CRC cis rs703842 0.616 rs7489290 chr12:58228588 C/G cg02175503 chr12:58329896 NA 0.45 5.73 0.3 2.27e-8 Multiple sclerosis; CRC cis rs3796352 0.892 rs58515094 chr3:52995575 C/T cg07884673 chr3:53033167 SFMBT1 0.7 6.15 0.32 2.23e-9 Immune reponse to smallpox (secreted IL-2); CRC cis rs919433 1.000 rs6741380 chr2:198165121 A/G cg10820045 chr2:198174542 NA 0.54 10.65 0.51 5.87e-23 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC cis rs896854 0.818 rs13262110 chr8:95926890 C/T cg23172400 chr8:95962367 TP53INP1 -0.44 -7.19 -0.37 4.4e-12 Type 2 diabetes; CRC cis rs7493 0.760 rs17876092 chr7:95053313 C/A cg07404485 chr7:94953653 PON1 -0.48 -6.03 -0.32 4.44e-9 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs1707322 1.000 rs10890381 chr1:46451771 T/G cg06784218 chr1:46089804 CCDC17 0.59 10.4 0.5 4.23e-22 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs4750440 0.712 rs11258776 chr10:14031709 G/T cg00551146 chr10:14014579 FRMD4A 0.42 6.9 0.36 2.67e-11 Adiponectin levels; CRC cis rs6951245 0.572 rs80133931 chr7:1027286 C/T cg26224354 chr7:1096374 C7orf50;GPR146 -0.97 -8.24 -0.41 4.03e-15 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs17401966 0.522 rs912962 chr1:10348712 G/T cg19773385 chr1:10388646 KIF1B 0.45 6.96 0.36 1.86e-11 Hepatocellular carcinoma; CRC cis rs11122272 0.735 rs11122279 chr1:231519804 A/G cg06096015 chr1:231504339 EGLN1 0.4 5.94 0.31 7.17e-9 Hemoglobin concentration; CRC cis rs6952808 0.929 rs2280546 chr7:1976863 G/A cg00106254 chr7:1943704 MAD1L1 -0.47 -6.5 -0.34 2.96e-10 Bipolar disorder and schizophrenia; CRC cis rs16852403 0.548 rs6685012 chr1:178175301 C/A cg00404053 chr1:178313656 RASAL2 0.5 6.58 0.34 1.88e-10 Childhood ear infection; CRC trans rs10982213 0.830 rs2274163 chr9:117188714 C/T cg12721145 chr4:109571876 OSTC 0.4 6.2 0.32 1.66e-9 Interleukin-6 levels; CRC cis rs6831352 0.918 rs7689753 chr4:100055575 A/G cg12011299 chr4:100065546 ADH4 -0.49 -9.27 -0.45 2.61e-18 Alcohol dependence; CRC cis rs25422 0.938 rs62422193 chr6:118912285 G/A cg18833306 chr6:118973337 C6orf204 0.43 5.63 0.3 3.92e-8 Renal cell carcinoma; CRC cis rs2836974 0.931 rs13047663 chr21:40708818 C/T cg11890956 chr21:40555474 PSMG1 0.92 13.64 0.6 6.69e-34 Cognitive function; CRC cis rs514406 0.798 rs576650 chr1:53327207 C/T cg27535305 chr1:53392650 SCP2 -0.42 -7.51 -0.38 5.79e-13 Monocyte count; CRC cis rs738322 0.640 rs738321 chr22:38568833 C/G cg03162506 chr22:38580953 NA 0.27 5.83 0.31 1.3e-8 Cutaneous nevi; CRC cis rs6831352 0.744 rs2602847 chr4:100025963 T/C cg12011299 chr4:100065546 ADH4 0.49 9.27 0.46 2.46e-18 Alcohol dependence; CRC cis rs10504229 0.683 rs11774847 chr8:58140775 T/A cg20607798 chr8:58055168 NA 0.54 6.2 0.32 1.68e-9 Developmental language disorder (linguistic errors); CRC cis rs853679 0.517 rs9368556 chr6:28131153 T/C cg15845792 chr6:28175446 NA 1.04 13.89 0.61 7.67e-35 Depression; CRC cis rs34638657 0.500 rs12446210 chr16:82185762 G/A cg07918374 chr16:82182319 MPHOSPH6 0.4 5.66 0.3 3.33e-8 Lung adenocarcinoma; CRC cis rs597539 0.652 rs602364 chr11:68662167 C/T cg21963583 chr11:68658836 MRPL21 0.63 11.58 0.54 3.15e-26 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs3858526 0.920 rs11039698 chr11:5950907 C/T cg02574844 chr11:5959923 NA -0.46 -6.45 -0.33 4.08e-10 DNA methylation (variation); CRC cis rs12477438 0.798 rs9308816 chr2:99637230 A/G cg14399236 chr2:99771627 LIPT1;TSGA10 -0.74 -10.39 -0.5 4.81e-22 Chronic sinus infection; CRC cis rs4764124 0.646 rs10846062 chr12:14965781 T/C cg19759883 chr12:14956454 WBP11;C12orf60 0.36 5.62 0.3 4.04e-8 Pubertal anthropometrics; CRC cis rs7635838 0.718 rs2594991 chr3:11362704 G/A cg00170343 chr3:11313890 ATG7 0.47 7.23 0.37 3.47e-12 HDL cholesterol; CRC cis rs17345786 0.861 rs79181492 chr3:101216021 G/A cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.6 6.83 0.35 4.22e-11 Colonoscopy-negative controls vs population controls; CRC cis rs28374715 0.532 rs316606 chr15:41772202 A/C cg18705301 chr15:41695430 NDUFAF1 -1.12 -19.25 -0.73 7.48e-56 Ulcerative colitis; CRC cis rs8177253 0.763 rs12769 chr3:133474328 G/A cg11941060 chr3:133502564 NA -0.56 -9.34 -0.46 1.47e-18 Iron status biomarkers; CRC cis rs2806561 0.734 rs2143156 chr1:23374629 T/G cg12483005 chr1:23474871 LUZP1 0.45 6.43 0.33 4.45e-10 Height; CRC cis rs2463822 0.925 rs72923272 chr11:62166832 G/A cg06239285 chr11:62104954 ASRGL1 -0.9 -9.39 -0.46 1.06e-18 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs4727027 0.870 rs1105261 chr7:148794442 T/G cg23583168 chr7:148888333 NA -0.83 -13.4 -0.59 5.47e-33 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC cis rs12692738 0.526 rs355832 chr2:165616833 C/T cg03182029 chr2:165697222 COBLL1 0.48 5.66 0.3 3.32e-8 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);Waist-to-hip ratio adjusted for BMI in non-smokers;Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction);Waist-to-hip ratio adjusted for body mass index; CRC cis rs8180040 0.966 rs11716763 chr3:47518266 C/T cg10298567 chr3:47292165 KIF9 0.38 6.09 0.32 3.06e-9 Colorectal cancer; CRC cis rs4727027 0.933 rs2158633 chr7:148832652 C/T cg23583168 chr7:148888333 NA -0.92 -15.93 -0.66 9.45e-43 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC cis rs8064299 0.597 rs4789098 chr17:72781292 C/G cg25054828 chr17:72772726 NAT9;TMEM104 0.81 13.48 0.6 2.74e-33 Monocyte count; CRC cis rs66887589 0.870 rs59590064 chr4:120539753 T/C cg09307838 chr4:120376055 NA -0.51 -7.88 -0.4 4.68e-14 Diastolic blood pressure; CRC trans rs10983614 1.000 rs7867776 chr9:120072627 A/G cg09781304 chr17:80887954 TBCD 0.42 5.97 0.31 6.12e-9 Survival in pancreatic cancer; CRC trans rs208520 1.000 rs12200490 chr6:66976084 G/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.89 11.01 0.52 3.28e-24 Exhaled nitric oxide output; CRC cis rs875971 0.545 rs316324 chr7:65610614 A/G cg18876405 chr7:65276391 NA -0.44 -6.14 -0.32 2.41e-9 Aortic root size; CRC cis rs4240897 0.935 rs1474868 chr1:12044164 A/G cg13216073 chr1:12042593 MFN2 -0.64 -10.72 -0.51 3.44e-23 Tuberculosis; CRC cis rs9296092 0.517 rs76361685 chr6:33536458 G/C cg13560919 chr6:33536144 NA -0.43 -5.86 -0.31 1.15e-8 Age at smoking initiation in chronic obstructive pulmonary disease; CRC cis rs908922 0.651 rs4240885 chr1:152529850 G/C cg09873164 chr1:152488093 CRCT1 0.4 6.72 0.35 7.83e-11 Hair morphology; CRC cis rs1707322 1.000 rs785519 chr1:46568562 C/T cg03146154 chr1:46216737 IPP -0.52 -7.18 -0.37 4.54e-12 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs8180040 0.620 rs6442055 chr3:47110722 A/G cg02527881 chr3:46936655 PTH1R -0.34 -5.87 -0.31 1.05e-8 Colorectal cancer; CRC cis rs2535633 0.631 rs2710346 chr3:52974152 C/T cg11645453 chr3:52864694 ITIH4 -0.4 -7.43 -0.38 9.61e-13 Body mass index; CRC cis rs8141529 0.719 rs9625619 chr22:29272328 T/A cg02153584 chr22:29168773 CCDC117 0.47 6.75 0.35 6.84e-11 Lymphocyte counts; CRC cis rs1832871 0.672 rs7745596 chr6:158732991 T/A cg07165851 chr6:158734300 TULP4 0.63 7.96 0.4 2.75e-14 Height; CRC cis rs11997175 0.624 rs7016783 chr8:33696831 A/G cg04338863 chr8:33670619 NA 0.42 6.75 0.35 6.5e-11 Body mass index; CRC cis rs3768617 0.510 rs10911254 chr1:183088627 A/G ch.1.3577855R chr1:183094577 LAMC1 0.89 15.86 0.66 1.84e-42 Fuchs's corneal dystrophy; CRC cis rs1832871 0.711 rs76962726 chr6:158674041 C/T cg07165851 chr6:158734300 TULP4 0.61 7.72 0.39 1.37e-13 Height; CRC cis rs938554 0.513 rs1014290 chr4:10001861 G/A cg00071950 chr4:10020882 SLC2A9 0.41 6.48 0.34 3.4e-10 Blood metabolite levels; CRC cis rs8180040 0.726 rs7625070 chr3:47095518 A/G cg02527881 chr3:46936655 PTH1R -0.37 -6.94 -0.36 2.13e-11 Colorectal cancer; CRC cis rs12451471 0.637 rs12452616 chr17:78090081 A/G cg12100956 chr17:78086420 GAA 0.39 6.27 0.33 1.12e-9 Plateletcrit;Mean corpuscular hemoglobin concentration; CRC cis rs6951245 1.000 rs78896566 chr7:1080182 C/G cg18402987 chr7:1209562 NA 0.64 6.78 0.35 5.48e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs801193 0.901 rs4273746 chr7:66301111 C/T cg00343986 chr7:65444356 GUSB -0.45 -6.31 -0.33 8.9e-10 Aortic root size; CRC cis rs10256972 0.713 rs10435026 chr7:1065948 A/G cg03188948 chr7:1209495 NA 0.43 6.09 0.32 3.18e-9 Longevity;Endometriosis; CRC cis rs7845219 0.539 rs713113 chr8:95877787 C/T cg23172400 chr8:95962367 TP53INP1 0.4 6.57 0.34 1.95e-10 Type 2 diabetes; CRC cis rs7940866 0.903 rs1820353 chr11:130870765 A/G cg12179176 chr11:130786555 SNX19 0.55 8.16 0.41 7.03e-15 Schizophrenia; CRC cis rs60843830 1.000 rs56167434 chr2:282137 G/C cg25945732 chr2:264204 ACP1;SH3YL1 0.71 11.42 0.53 1.19e-25 Spherical equivalent (joint analysis main effects and education interaction); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg24103979 chr1:155829285 SYT11 0.42 6.04 0.32 4.23e-9 Intelligence (multi-trait analysis); CRC cis rs9486715 1.000 rs6899647 chr6:97065661 A/G cg18709589 chr6:96969512 KIAA0776 -0.48 -6.78 -0.35 5.64e-11 Headache; CRC cis rs7917772 0.502 rs10748827 chr10:104368336 G/T cg11453585 chr10:104263688 ACTR1A;SUFU 0.88 15.93 0.66 9.42e-43 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC cis rs853679 0.517 rs4713143 chr6:28106759 A/C cg02683197 chr6:28174875 NA 0.85 10.52 0.5 1.71e-22 Depression; CRC cis rs4523957 0.928 rs6502155 chr17:2176964 A/G cg16513277 chr17:2031491 SMG6 -0.54 -9.12 -0.45 7.71e-18 Autism spectrum disorder or schizophrenia;Schizophrenia; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg11556929 chr2:240323605 HDAC4 0.39 6.09 0.32 3.16e-9 Intelligence (multi-trait analysis); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg06614563 chr5:89770451 MBLAC2;POLR3G 0.42 6.15 0.32 2.26e-9 Intelligence (multi-trait analysis); CRC cis rs9733 0.596 rs11586422 chr1:150679358 C/T cg18016565 chr1:150552671 MCL1 0.45 6.52 0.34 2.57e-10 Tonsillectomy; CRC cis rs11997175 0.511 rs4613957 chr8:33673130 C/T ch.8.33884649F chr8:33765107 NA -0.44 -6.77 -0.35 6.08e-11 Body mass index; CRC cis rs12325245 0.536 rs12709002 chr16:58614337 A/C cg26666090 chr16:58549219 SETD6 0.84 5.65 0.3 3.55e-8 Schizophrenia; CRC cis rs943466 0.513 rs943467 chr6:33731811 A/T cg25922239 chr6:33757077 LEMD2 0.41 6.23 0.32 1.45e-9 Body mass index (joint analysis main effects and physical activity interaction);Body mass index; CRC cis rs1552244 0.816 rs56271597 chr3:10042790 C/T cg18598329 chr3:10140678 FANCD2;C3orf24 -0.81 -10.55 -0.5 1.36e-22 Alzheimer's disease; CRC cis rs8060686 0.641 rs75909028 chr16:68089578 A/C cg26727032 chr16:67993705 SLC12A4 -0.59 -6.7 -0.35 9.01e-11 HDL cholesterol;Metabolic syndrome; CRC cis rs77861329 1.000 rs9809977 chr3:52166147 T/C cg08692210 chr3:52188851 WDR51A 0.86 7.84 0.4 6.46e-14 Macrophage inflammatory protein 1b levels; CRC cis rs7613875 0.537 rs6446195 chr3:50070853 A/G cg05623727 chr3:50126028 RBM5 -0.59 -10.15 -0.49 3.05e-21 Body mass index; CRC cis rs17021463 0.966 rs7657789 chr4:95178589 C/T cg11021082 chr4:95130006 SMARCAD1 -0.59 -9.42 -0.46 8.39e-19 Testicular germ cell tumor; CRC cis rs2688608 0.620 rs7098444 chr10:75580042 C/T cg16540259 chr10:75572220 NDST2 0.38 6.29 0.33 1.02e-9 Inflammatory bowel disease; CRC cis rs4666002 0.956 rs2384656 chr2:27832055 A/G cg27432699 chr2:27873401 GPN1 0.49 6.45 0.33 4.09e-10 Phospholipid levels (plasma); CRC trans rs1005277 0.540 rs11011351 chr10:38030525 A/G cg17830980 chr10:43048298 ZNF37B -0.4 -6.24 -0.33 1.38e-9 Extrinsic epigenetic age acceleration; CRC cis rs11122272 0.735 rs2739516 chr1:231505527 G/A cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.54 -8.11 -0.41 1.04e-14 Hemoglobin concentration; CRC trans rs11098499 0.909 rs79704848 chr4:120309351 T/A cg25214090 chr10:38739885 LOC399744 0.62 9.74 0.47 7.35e-20 Corneal astigmatism; CRC cis rs4862750 0.624 rs34414639 chr4:187873417 C/A cg27532560 chr4:187881888 NA -0.54 -9.79 -0.47 4.95e-20 Lobe attachment (rater-scored or self-reported); CRC trans rs4698169 0.510 rs675984 chr4:17123821 A/G ch.8.34907260F chr8:34787718 NA 0.75 6.65 0.34 1.24e-10 Temperament (bipolar disorder); CRC cis rs2346177 0.542 rs6718875 chr2:46687982 G/T cg26688816 chr2:46740690 ATP6V1E2 -0.62 -9.37 -0.46 1.17e-18 HDL cholesterol; CRC cis rs9768139 0.733 rs35016950 chr7:158118710 C/A cg06219351 chr7:158114137 PTPRN2 -0.54 -8.19 -0.41 5.81e-15 Calcium levels; CRC cis rs6582630 0.519 rs11495700 chr12:38288240 A/G cg13010199 chr12:38710504 ALG10B 0.46 5.93 0.31 7.62e-9 Drug-induced liver injury (flucloxacillin); CRC cis rs2952156 0.883 rs907089 chr17:37833600 C/T cg20243544 chr17:37824526 PNMT 0.55 8.85 0.44 5.62e-17 Asthma; CRC cis rs13256369 0.774 rs13260303 chr8:8587342 A/C cg06636001 chr8:8085503 FLJ10661 0.5 6.52 0.34 2.69e-10 Obesity-related traits; CRC cis rs12024301 0.557 rs57403433 chr1:183622951 G/A cg11505048 chr1:183622726 RGL1;APOBEC4 0.81 7.0 0.36 1.42e-11 Peripheral arterial disease (traffic-related air pollution interaction); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg07610776 chr16:1832675 SPSB3;NUBP2 0.45 6.22 0.32 1.54e-9 Response to antipsychotic treatment; CRC cis rs951366 0.617 rs9438393 chr1:205782718 A/G cg17178900 chr1:205818956 PM20D1 0.84 13.37 0.59 7.39e-33 Menarche (age at onset); CRC cis rs4423214 0.879 rs12803256 chr11:71132868 A/G cg05163923 chr11:71159392 DHCR7 0.65 9.25 0.45 2.83e-18 Vitamin D levels; CRC cis rs72781680 0.898 rs72782106 chr2:24022009 A/G cg08917208 chr2:24149416 ATAD2B 0.98 9.51 0.46 4.15e-19 Lymphocyte counts; CRC cis rs7659604 1.000 rs34952897 chr4:122664409 C/T cg20573242 chr4:122745356 CCNA2 0.41 6.15 0.32 2.27e-9 Type 2 diabetes; CRC trans rs783540 0.656 rs783538 chr15:83253143 C/G cg18393722 chr15:85113863 UBE2QP1 -0.39 -6.17 -0.32 1.99e-9 Schizophrenia; CRC trans rs1459104 0.778 rs17149846 chr11:55793788 T/C cg03313212 chr12:104850718 CHST11 -0.5 -5.99 -0.31 5.37e-9 Body mass index; CRC cis rs6957923 0.967 rs35133514 chr7:23501808 C/T cg20265043 chr7:23510089 IGF2BP3 0.37 5.68 0.3 3.03e-8 Height; CRC cis rs1697139 1.000 rs1705397 chr5:66511062 G/T cg16691251 chr5:66510806 NA -0.61 -11.36 -0.53 1.85e-25 Breast cancer; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg14843989 chr17:10600751 C17orf48;SCO1 0.38 6.08 0.32 3.37e-9 Liver disease severity in Alagille syndrome; CRC cis rs2415984 0.622 rs2123126 chr14:46926609 C/T cg14871534 chr14:47121158 RPL10L -0.43 -6.19 -0.32 1.8e-9 Number of children ever born; CRC trans rs877282 0.898 rs35743076 chr10:758991 C/T cg22713356 chr15:30763199 NA 1.23 15.11 0.64 1.55e-39 Uric acid levels; CRC trans rs1814175 0.645 rs7952104 chr11:49964180 C/T cg11707556 chr5:10655725 ANKRD33B -0.53 -10.07 -0.49 5.92e-21 Height; CRC cis rs728616 0.867 rs12414877 chr10:81780708 A/G cg11900509 chr10:81946545 ANXA11 -0.68 -6.75 -0.35 6.81e-11 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs6495122 0.501 rs7163636 chr15:75346760 C/T cg14664628 chr15:75095509 CSK -0.48 -7.18 -0.37 4.54e-12 Caffeine consumption;Diastolic blood pressure;Coffee consumption; CRC cis rs7572644 0.679 rs6745545 chr2:28021845 C/G cg27432699 chr2:27873401 GPN1 0.47 6.15 0.32 2.27e-9 Response to carboplatin and paclitaxel in ovarian cancer (Caspase 3/7 EC50); CRC cis rs7618915 0.547 rs68021750 chr3:52624769 G/A cg11645453 chr3:52864694 ITIH4 0.35 6.13 0.32 2.58e-9 Bipolar disorder; CRC cis rs514406 0.929 rs554301 chr1:53321948 A/T cg27535305 chr1:53392650 SCP2 0.36 6.73 0.35 7.51e-11 Monocyte count; CRC cis rs933688 1.000 rs332529 chr5:90789470 G/A cg26981201 chr5:90679533 LOC100129716;ARRDC3 0.97 15.5 0.65 4.39e-41 Smoking behavior; CRC cis rs7493 1.000 rs12155103 chr7:95037131 G/A cg04155289 chr7:94953770 PON1 -0.59 -7.53 -0.38 5.06e-13 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs1005277 0.540 rs2224248 chr10:38451886 A/G cg17219203 chr10:38645113 HSD17B7P2 -0.4 -5.68 -0.3 2.89e-8 Extrinsic epigenetic age acceleration; CRC cis rs7527798 0.592 rs2025372 chr1:207829653 T/G cg21110645 chr1:207815933 NA -0.39 -6.18 -0.32 1.9e-9 Erythrocyte sedimentation rate; CRC cis rs1003719 0.680 rs3992 chr21:38505969 G/A cg10648535 chr21:38446584 PIGP;TTC3 -0.48 -6.7 -0.35 8.99e-11 Eye color traits; CRC cis rs4285028 0.948 rs12493952 chr3:121708497 C/T cg11130432 chr3:121712080 ILDR1 -0.5 -6.61 -0.34 1.56e-10 Multiple sclerosis; CRC cis rs1008375 1.000 rs28545485 chr4:17645376 C/T cg04450456 chr4:17643702 FAM184B 0.41 6.72 0.35 8.23e-11 Parasitemia in Tripanosoma cruzi seropositivity; CRC trans rs1871744 1.000 rs1871744 chr4:89039629 C/T cg04322572 chr10:43447618 NA -0.35 -6.08 -0.32 3.36e-9 Renal underexcretion gout; CRC cis rs4713118 0.662 rs149900 chr6:28014597 C/T cg12273811 chr6:28175739 NA 0.6 8.03 0.4 1.74e-14 Parkinson's disease; CRC cis rs7537052 0.669 rs2296263 chr1:36641729 C/T cg25304816 chr1:36627734 MAP7D1 0.45 7.03 0.36 1.21e-11 Schizophrenia; CRC cis rs4974559 0.594 rs11946384 chr4:1313566 T/C cg02980000 chr4:1222292 CTBP1 0.48 6.06 0.32 3.76e-9 Systolic blood pressure; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg14640751 chr11:111636595 PPP2R1B 0.47 6.83 0.35 4.06e-11 Response to antipsychotic treatment; CRC cis rs1707322 1.000 rs7547189 chr1:46319514 C/A cg06784218 chr1:46089804 CCDC17 0.51 8.99 0.44 1.94e-17 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs1552244 0.938 rs67667957 chr3:10167264 G/C cg18598329 chr3:10140678 FANCD2;C3orf24 -0.85 -11.33 -0.53 2.36e-25 Alzheimer's disease; CRC cis rs4692589 0.758 rs6823836 chr4:170933159 T/C cg19918862 chr4:170955249 NA 0.35 5.69 0.3 2.78e-8 Anxiety disorder; CRC cis rs6582630 0.519 rs11609739 chr12:38547969 G/A cg13010199 chr12:38710504 ALG10B 0.47 6.0 0.31 5.3300000000000004e-09 Drug-induced liver injury (flucloxacillin); CRC cis rs9322193 0.886 rs12525871 chr6:150097018 A/G cg13206674 chr6:150067644 NUP43 0.55 7.88 0.4 4.99e-14 Lung cancer; CRC cis rs9309711 0.883 rs13429373 chr2:3477014 G/A cg10845886 chr2:3471009 TTC15 -0.74 -11.93 -0.55 1.66e-27 Neurofibrillary tangles; CRC trans rs7937682 0.883 rs542831 chr11:111471392 T/A cg18187862 chr3:45730750 SACM1L 0.48 6.91 0.36 2.54e-11 Primary sclerosing cholangitis; CRC cis rs1552244 0.882 rs2030564 chr3:10039044 A/G cg10729496 chr3:10149963 C3orf24 0.49 6.39 0.33 5.52e-10 Alzheimer's disease; CRC cis rs17023223 0.537 rs4508058 chr1:119684250 T/C cg05756136 chr1:119680316 WARS2 -0.53 -7.21 -0.37 3.87e-12 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for BMI in active individuals; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg05634287 chr5:148931071 CSNK1A1 0.45 6.12 0.32 2.66e-9 Anxiety disorder; CRC cis rs3087591 0.959 rs9893872 chr17:29571195 G/A cg24425628 chr17:29625626 OMG;NF1 -0.84 -16.19 -0.67 8.76e-44 Hip circumference; CRC cis rs155076 0.666 rs2015241 chr13:21888254 A/G cg06138931 chr13:21896616 NA 0.53 6.68 0.35 1.05e-10 White matter hyperintensity burden; CRC cis rs7208859 0.524 rs59913838 chr17:29101563 A/T cg01831904 chr17:28903510 LRRC37B2 -0.63 -6.53 -0.34 2.51e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs3106136 0.967 rs12646184 chr4:95183216 A/G cg11021082 chr4:95130006 SMARCAD1 0.47 7.24 0.37 3.26e-12 Capecitabine sensitivity; CRC cis rs6495122 0.699 rs4886410 chr15:75065644 G/C cg14664628 chr15:75095509 CSK -0.67 -10.65 -0.51 6.04e-23 Caffeine consumption;Diastolic blood pressure;Coffee consumption; CRC cis rs9296095 1.000 rs5745582 chr6:33546498 C/T cg14003231 chr6:33640908 ITPR3 0.5 7.27 0.37 2.59e-12 Platelet count; CRC cis rs8180040 0.874 rs11130123 chr3:47285912 A/G cg27129171 chr3:47204927 SETD2 0.63 9.96 0.48 1.35e-20 Colorectal cancer; CRC cis rs10045504 0.502 rs72746032 chr5:38743982 T/C cg15396434 chr5:38725168 NA -0.6 -6.01 -0.31 4.86e-9 Night sleep phenotypes; CRC cis rs58235267 0.544 rs12478556 chr2:63341711 T/A cg24726965 chr2:63606136 C2orf86 -0.37 -5.71 -0.3 2.54e-8 Prostate-specific antigen levels (conditioned on lead SNPs); CRC cis rs6582630 0.502 rs3902522 chr12:38271203 T/C cg13010199 chr12:38710504 ALG10B 0.45 5.95 0.31 6.72e-9 Drug-induced liver injury (flucloxacillin); CRC cis rs77633900 0.614 rs2439992 chr15:76863023 T/G cg21673338 chr15:77095150 SCAPER -0.78 -8.67 -0.43 1.99e-16 Non-glioblastoma glioma;Glioma; CRC cis rs2762353 0.538 rs35670731 chr6:25728235 C/T cg12310025 chr6:25882481 NA 0.75 10.78 0.51 2.06e-23 Blood metabolite levels; CRC cis rs1559088 0.948 rs12610266 chr19:33581237 C/G cg27124370 chr19:33622961 WDR88 -0.43 -6.03 -0.32 4.31e-9 Bone ultrasound measurement (broadband ultrasound attenuation); CRC cis rs4665809 0.590 rs72809668 chr2:26467653 C/T cg27170947 chr2:26402098 FAM59B 0.59 7.71 0.39 1.53e-13 Gut microbiome composition (summer); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg12553538 chr17:8191987 RANGRF;SLC25A35 0.37 6.0 0.31 5.17e-9 Liver disease severity in Alagille syndrome; CRC cis rs3789045 1.000 rs61817485 chr1:204595592 G/A cg17419461 chr1:204415978 PIK3C2B -0.45 -7.01 -0.36 1.34e-11 Educational attainment (college completion); CRC cis rs7246657 0.943 rs1373991 chr19:37838911 T/C cg23950597 chr19:37808831 NA -0.47 -5.76 -0.3 1.94e-8 Coronary artery calcification; CRC cis rs1451375 0.669 rs4469404 chr7:50647062 C/T cg18232548 chr7:50535776 DDC -0.46 -6.54 -0.34 2.31e-10 Malaria; CRC cis rs711245 0.670 rs7560321 chr2:36822318 C/G cg15105969 chr2:36825350 FEZ2 -0.48 -6.91 -0.36 2.48e-11 Height; CRC cis rs2115630 0.967 rs11073731 chr15:85355113 C/A cg09876464 chr15:85330779 ZNF592 0.47 7.95 0.4 2.97e-14 P wave terminal force; CRC cis rs6691722 0.503 rs3765427 chr1:24705567 G/A cg02336364 chr1:24764700 NIPAL3 0.37 6.15 0.32 2.19e-9 Response to interferon beta in multiple sclerosis; CRC trans rs925098 0.577 rs2724470 chr4:17996046 A/G cg05788437 chr3:197476880 FYTTD1;KIAA0226 -0.44 -6.7 -0.35 8.87e-11 Birth weight;Height; CRC cis rs9942416 0.660 rs67054144 chr5:74991443 G/A cg19683494 chr5:74908142 NA 0.5 6.28 0.33 1.06e-9 Age-related disease endophenotypes; CRC cis rs873946 0.648 rs1543593 chr10:134553185 A/T cg27286337 chr10:134555280 INPP5A 0.81 10.08 0.49 5.3e-21 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CRC cis rs7223966 0.961 rs112709843 chr17:61836936 T/A cg05941027 chr17:61774174 LIMD2 0.33 5.75 0.3 1.99e-8 Hip circumference adjusted for BMI;Body mass index; CRC cis rs1448094 1.000 rs10083080 chr12:86348579 G/C cg18827107 chr12:86230957 RASSF9 -0.39 -6.34 -0.33 7.39e-10 Major depressive disorder; CRC trans rs2303319 0.504 rs62188988 chr2:162531068 T/C cg10272801 chr16:14013773 ERCC4 -0.69 -6.22 -0.32 1.49e-9 Cognitive function; CRC cis rs9322193 0.923 rs9688350 chr6:150052113 A/T cg05861140 chr6:150128134 PCMT1 -0.38 -5.93 -0.31 7.58e-9 Lung cancer; CRC cis rs1448094 0.533 rs7307617 chr12:86151317 T/C cg00310523 chr12:86230176 RASSF9 -0.37 -6.06 -0.32 3.82e-9 Major depressive disorder; CRC cis rs6815814 0.950 rs56289835 chr4:38811845 G/C cg06935464 chr4:38784597 TLR10 0.55 5.74 0.3 2.12e-8 Breast cancer; CRC cis rs4664304 0.772 rs17830558 chr2:160878364 A/C cg03641300 chr2:160917029 PLA2R1 -0.45 -6.44 -0.33 4.3e-10 Crohn's disease;Inflammatory bowel disease; CRC cis rs4319547 0.656 rs10161534 chr12:122873864 T/C cg05707623 chr12:122985044 ZCCHC8 -0.64 -7.88 -0.4 4.7e-14 Body mass index; CRC cis rs950169 0.959 rs12911210 chr15:84792083 A/C cg11189052 chr15:85197271 WDR73 0.6 8.9 0.44 3.69e-17 Schizophrenia; CRC trans rs3942852 0.774 rs10838813 chr11:48186969 C/A cg03929089 chr4:120376271 NA -0.72 -9.04 -0.45 1.42e-17 Acute lymphoblastic leukemia (childhood); CRC cis rs9457247 0.646 rs4710160 chr6:167409241 T/A cg23791538 chr6:167370224 RNASET2 -0.39 -6.08 -0.32 3.37e-9 Crohn's disease; CRC cis rs7512552 0.839 rs834231 chr1:150389392 A/T cg15654264 chr1:150340011 RPRD2 -0.61 -8.86 -0.44 4.98e-17 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); CRC cis rs58799304 0.590 rs3738593 chr1:156045973 C/T cg15685922 chr1:156045208 MEX3A -0.48 -7.97 -0.4 2.64e-14 Ischemic stroke; CRC cis rs2745967 0.715 rs1474740 chr1:208069741 A/G cg09788693 chr1:208063733 CD34 0.45 6.74 0.35 7.14e-11 Resting heart rate; CRC cis rs754466 0.706 rs7099526 chr10:79657705 C/G cg26805224 chr10:79626177 DLG5 -0.52 -7.32 -0.37 1.92e-12 Liver enzyme levels (gamma-glutamyl transferase); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg18358588 chr6:26660131 ZNF322A 0.47 7.54 0.38 4.71e-13 Liver disease severity in Alagille syndrome; CRC cis rs907683 0.635 rs11691617 chr2:220295167 C/T cg15015639 chr2:220282977 DES 0.36 5.79 0.3 1.68e-8 Resting heart rate; CRC cis rs5750830 0.649 rs2413590 chr22:39790191 G/C cg11247378 chr22:39784982 NA -0.43 -7.81 -0.4 7.77e-14 Intelligence (multi-trait analysis); CRC cis rs9467711 0.606 rs9379864 chr6:26372584 G/A cg16898833 chr6:26189333 HIST1H4D 0.76 6.58 0.34 1.84e-10 Autism spectrum disorder or schizophrenia; CRC cis rs1552244 0.572 rs57268864 chr3:10164233 C/A cg08888203 chr3:10149979 C3orf24 0.71 8.57 0.43 4.18e-16 Alzheimer's disease; CRC cis rs10504229 0.954 rs114134184 chr8:58181969 G/A cg05313129 chr8:58192883 C8orf71 -0.47 -6.99 -0.36 1.49e-11 Developmental language disorder (linguistic errors); CRC cis rs992157 0.835 rs4674282 chr2:219144230 A/T cg04880052 chr2:219191631 PNKD -0.42 -6.73 -0.35 7.33e-11 Colorectal cancer; CRC cis rs9522267 0.535 rs12583489 chr13:112233455 G/A cg14352298 chr13:112236639 NA 0.29 6.67 0.35 1.1e-10 Hepatitis; CRC cis rs72627123 0.867 rs77320708 chr14:74478482 T/C cg12022184 chr14:74485813 ENTPD5;C14orf45 0.72 6.19 0.32 1.8e-9 Morning vs. evening chronotype; CRC cis rs6088580 0.634 rs6058041 chr20:33018008 A/G cg08999081 chr20:33150536 PIGU 0.63 11.56 0.54 3.61e-26 Glomerular filtration rate (creatinine); CRC cis rs3026101 0.671 rs9789002 chr17:5298792 T/C cg25236894 chr17:5323110 RPAIN;NUP88 0.42 6.84 0.35 3.8e-11 Body mass index; CRC cis rs10504229 0.679 rs11783965 chr8:58130510 T/G cg02725872 chr8:58115012 NA -0.64 -11.45 -0.53 8.66e-26 Developmental language disorder (linguistic errors); CRC cis rs10504229 0.728 rs1495867 chr8:58155500 G/T cg08219700 chr8:58056026 NA 0.45 5.74 0.3 2.11e-8 Developmental language disorder (linguistic errors); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg06994090 chr5:76011849 F2R 0.39 6.52 0.34 2.67e-10 Liver disease severity in Alagille syndrome; CRC cis rs1451375 0.617 rs1807066 chr7:50543683 T/C cg18232548 chr7:50535776 DDC -0.44 -5.76 -0.3 1.9e-8 Malaria; CRC cis rs1448094 0.512 rs7953318 chr12:86245929 G/A cg18827107 chr12:86230957 RASSF9 -0.45 -7.49 -0.38 6.6e-13 Major depressive disorder; CRC cis rs12541335 0.590 rs11136002 chr8:22217082 C/T cg02788857 chr8:22132959 PIWIL2 0.51 8.67 0.43 2e-16 Hypertriglyceridemia; CRC cis rs1448094 0.511 rs61930074 chr12:86218759 G/C cg02569458 chr12:86230093 RASSF9 0.42 7.2 0.37 4.01e-12 Major depressive disorder; CRC cis rs9660180 0.967 rs10907191 chr1:1774820 A/T cg17747265 chr1:1875780 NA -0.77 -13.05 -0.58 1.19e-31 Body mass index; CRC cis rs8180040 0.966 rs60369822 chr3:47479735 A/C cg02527881 chr3:46936655 PTH1R 0.37 6.84 0.35 3.78e-11 Colorectal cancer; CRC cis rs2731664 0.792 rs465670 chr5:176877624 C/T cg23176889 chr5:176863531 GRK6 -0.74 -16.15 -0.66 1.3e-43 Intelligence (multi-trait analysis); CRC cis rs9649213 0.593 rs6465673 chr7:97968887 C/T cg21770322 chr7:97807741 LMTK2 0.52 8.47 0.42 8.04e-16 Prostate cancer (SNP x SNP interaction); CRC trans rs10802346 0.545 rs10802347 chr1:246374268 G/A cg13514129 chr1:39547527 MACF1 0.66 10.12 0.49 3.84e-21 Fractional exhaled nitric oxide (childhood); CRC cis rs7786808 0.608 rs7784758 chr7:158214386 A/G cg17401720 chr7:158221031 PTPRN2 0.44 7.4 0.38 1.16e-12 Obesity-related traits; CRC cis rs6952808 0.771 rs10950415 chr7:1914477 A/G cg02951883 chr7:2050386 MAD1L1 -0.57 -9.64 -0.47 1.6e-19 Bipolar disorder and schizophrenia; CRC cis rs853679 0.517 rs56364346 chr6:28050762 T/G cg21251018 chr6:28226885 NKAPL 0.48 6.29 0.33 9.93e-10 Depression; CRC cis rs9807989 0.507 rs10439410 chr2:102990788 A/C cg03938978 chr2:103052716 IL18RAP -0.6 -10.37 -0.5 5.61e-22 Asthma; CRC cis rs11098499 0.820 rs13128602 chr4:120459366 C/T cg09307838 chr4:120376055 NA -0.66 -10.1 -0.49 4.67e-21 Corneal astigmatism; CRC cis rs2991971 0.967 rs644915 chr1:46007002 T/C cg24296786 chr1:45957014 TESK2 0.52 7.75 0.39 1.14e-13 High light scatter reticulocyte count; CRC cis rs877282 0.838 rs34778553 chr10:796865 T/C cg06581033 chr10:766294 NA -0.51 -5.78 -0.3 1.76e-8 Uric acid levels; CRC cis rs9457247 0.544 rs6920858 chr6:167464630 G/A cg07741184 chr6:167504864 NA 0.44 7.45 0.38 8.14e-13 Crohn's disease; CRC trans rs2303319 0.504 rs16845997 chr2:162521046 C/A cg12500891 chr11:57225987 NA -0.67 -6.03 -0.32 4.51e-9 Cognitive function; CRC cis rs7945705 0.967 rs56316046 chr11:8876598 G/T cg21881798 chr11:8931708 C11orf17;ST5 0.67 10.23 0.49 1.65e-21 Hemoglobin concentration; CRC cis rs3790645 1.000 rs188158 chr1:26898142 A/G cg17456097 chr1:26900765 RPS6KA1 0.44 6.63 0.34 1.41e-10 Glucose homeostasis traits; CRC cis rs4972806 0.668 rs2072588 chr2:177042930 G/C cg25347419 chr2:177043501 NA 0.58 9.0 0.44 1.88e-17 IgG glycosylation; CRC cis rs789852 0.867 rs1773175 chr3:194317732 G/A cg21106136 chr3:194405973 FAM43A -0.73 -5.98 -0.31 5.77e-9 QT interval; CRC cis rs4700695 0.841 rs433773 chr5:65309609 G/C cg21114390 chr5:65439923 SFRS12 0.62 6.54 0.34 2.32e-10 Facial morphology (factor 19); CRC cis rs4474465 0.850 rs10793327 chr11:78256841 A/C cg02023728 chr11:77925099 USP35 -0.37 -6.26 -0.33 1.19e-9 Alzheimer's disease (survival time); CRC cis rs61160187 0.582 rs67490467 chr5:60263818 G/C cg16298547 chr5:60138761 ELOVL7 -0.27 -5.74 -0.3 2.15e-8 Educational attainment (years of education);Educational attainment (college completion); CRC cis rs728616 0.867 rs1537835 chr10:81830152 C/G cg05935833 chr10:81318306 SFTPA2 -0.47 -5.93 -0.31 7.48e-9 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs11723261 0.582 rs4582104 chr4:136942 A/T cg12746427 chr4:53362 ZNF718;ZNF595 0.53 7.69 0.39 1.71e-13 Immune response to smallpox vaccine (IL-6); CRC cis rs9322193 0.923 rs9285524 chr6:150015258 G/A cg13206674 chr6:150067644 NUP43 0.57 8.27 0.41 3.37e-15 Lung cancer; CRC cis rs10540 1.000 rs12419716 chr11:503385 C/G cg19913688 chr11:428466 ANO9 -0.7 -7.19 -0.37 4.26e-12 Body mass index; CRC cis rs34375054 0.526 rs4412800 chr12:125674742 C/T cg06287003 chr12:125626642 AACS 0.52 7.07 0.36 9.62e-12 Post bronchodilator FEV1/FVC ratio; CRC trans rs7267979 1.000 rs1888999 chr20:25291848 C/T cg17903999 chr18:56338584 MALT1 -0.45 -7.38 -0.38 1.27e-12 Liver enzyme levels (alkaline phosphatase); CRC cis rs11122272 0.735 rs2790882 chr1:231532783 A/G cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX 0.57 8.35 0.42 1.87e-15 Hemoglobin concentration; CRC cis rs7671266 0.668 rs6834055 chr4:10158511 A/T cg11266682 chr4:10021025 SLC2A9 -0.4 -5.92 -0.31 8.07e-9 Cardiovascular disease risk factors; CRC cis rs832540 0.898 rs2662024 chr5:56257515 T/C cg24531977 chr5:56204891 C5orf35 0.48 7.65 0.39 2.28e-13 Coronary artery disease; CRC cis rs155076 0.938 rs536209 chr13:21847714 C/T cg25811766 chr13:21894605 NA -0.58 -5.99 -0.31 5.56e-9 White matter hyperintensity burden; CRC cis rs6662572 0.774 rs9429188 chr1:46570879 A/T cg08644498 chr1:46502608 NA 0.46 7.36 0.38 1.45e-12 Blood protein levels; CRC cis rs7737355 0.947 rs31583 chr5:130992432 T/C cg06307176 chr5:131281290 NA 0.41 5.89 0.31 9.38e-9 Life satisfaction; CRC cis rs172166 0.637 rs1225597 chr6:28162087 C/T cg25164649 chr6:28176230 NA 0.67 10.08 0.49 5.35e-21 Cardiac Troponin-T levels; CRC cis rs1878931 0.696 rs35175748 chr16:3445427 C/G cg26668626 chr16:3451006 ZNF174;ZNF434 1.0 17.5 0.69 6.15e-49 Body mass index (adult); CRC cis rs473651 0.935 rs10170056 chr2:239339291 G/C cg21699342 chr2:239360505 ASB1 0.52 8.21 0.41 5.22e-15 Multiple system atrophy; CRC cis rs10242455 0.702 rs17161700 chr7:98977067 A/G cg18809830 chr7:99032528 PTCD1 -0.95 -7.04 -0.36 1.1e-11 Blood metabolite levels; CRC cis rs10504229 0.683 rs79284841 chr8:58107611 T/A cg24829409 chr8:58192753 C8orf71 -0.69 -8.31 -0.42 2.49e-15 Developmental language disorder (linguistic errors); CRC cis rs7552404 0.655 rs5745336 chr1:76273519 G/A cg03433033 chr1:76189801 ACADM 0.69 9.08 0.45 1.03e-17 Blood metabolite levels;Acylcarnitine levels; CRC cis rs7113874 0.569 rs10769915 chr11:8597449 C/G cg02811074 chr11:8615871 STK33 -0.36 -6.11 -0.32 2.85e-9 Body mass index in physically active individuals;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs10504229 0.595 rs77615399 chr8:58117394 C/G cg05313129 chr8:58192883 C8orf71 -0.43 -6.11 -0.32 2.74e-9 Developmental language disorder (linguistic errors); CRC cis rs9916302 0.851 rs12936646 chr17:37647450 A/T cg03013999 chr17:37608204 MED1 0.45 6.77 0.35 5.76e-11 Glomerular filtration rate (creatinine); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg07007050 chr12:31882290 AMN1 0.38 6.01 0.31 4.87e-9 Liver disease severity in Alagille syndrome; CRC cis rs600231 0.508 rs11227201 chr11:65242548 G/A cg17120908 chr11:65337727 SSSCA1 -0.68 -7.56 -0.38 4.09e-13 Bone mineral density; CRC cis rs6546324 0.625 rs4533457 chr2:67787348 T/G cg15745817 chr2:67799979 NA -0.53 -8.45 -0.42 9.22e-16 Endometriosis; CRC cis rs57590327 0.503 rs13073613 chr3:81888512 C/A cg07356753 chr3:81810745 GBE1 -0.57 -7.77 -0.39 9.98e-14 Extraversion; CRC trans rs529967 0.757 rs687487 chr3:124166908 A/T cg01377916 chr16:46654868 SHCBP1 0.48 6.16 0.32 2.18e-9 Acute graft versus host disease in bone marrow transplantation (donor effect); CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg09455096 chr2:61765470 XPO1 0.51 6.57 0.34 1.92e-10 Thyroid stimulating hormone; CRC cis rs66887589 0.616 rs11732621 chr4:120212883 A/C cg09307838 chr4:120376055 NA 0.55 8.4 0.42 1.31e-15 Diastolic blood pressure; CRC cis rs9942416 0.592 rs10462521 chr5:74985867 T/C cg19683494 chr5:74908142 NA 0.5 6.26 0.33 1.22e-9 Age-related disease endophenotypes; CRC cis rs870825 0.616 rs6810600 chr4:185616814 T/C cg04058563 chr4:185651563 MLF1IP 0.72 9.2 0.45 4.12e-18 Blood protein levels; CRC cis rs7107174 0.688 rs2063725 chr11:78133452 T/G cg12700464 chr11:78128424 GAB2 -0.47 -5.66 -0.3 3.38e-8 Testicular germ cell tumor; CRC cis rs13315871 0.929 rs13322000 chr3:58286929 G/A cg20936604 chr3:58311152 NA -0.74 -6.94 -0.36 2.05e-11 Cholesterol, total; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg07119616 chr9:129452879 LMX1B 0.43 6.03 0.32 4.39e-9 Thyroid stimulating hormone; CRC cis rs6952808 0.756 rs12537348 chr7:1948172 C/G cg04267008 chr7:1944627 MAD1L1 -0.83 -12.66 -0.57 3.26e-30 Bipolar disorder and schizophrenia; CRC trans rs6550704 0.687 rs9865314 chr3:22634337 A/G cg02567788 chr10:71992279 PPA1 -0.45 -6.62 -0.34 1.48e-10 Daytime sleep phenotypes; CRC cis rs8180040 0.620 rs749511 chr3:47035735 A/C cg27129171 chr3:47204927 SETD2 -0.74 -12.12 -0.56 3.27e-28 Colorectal cancer; CRC cis rs9486715 0.867 rs4839687 chr6:96951732 C/A cg18709589 chr6:96969512 KIAA0776 0.49 7.2 0.37 4.09e-12 Headache; CRC cis rs7512552 0.839 rs11205357 chr1:150267798 T/C cg15654264 chr1:150340011 RPRD2 -0.57 -7.93 -0.4 3.36e-14 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); CRC cis rs7618915 0.501 rs3733045 chr3:52643307 A/G cg08222913 chr3:52553049 STAB1 -0.35 -6.55 -0.34 2.17e-10 Bipolar disorder; CRC cis rs5750830 0.597 rs4821889 chr22:39777254 T/C cg11247378 chr22:39784982 NA -0.49 -9.39 -0.46 1.03e-18 Intelligence (multi-trait analysis); CRC cis rs10504229 0.683 rs11784908 chr8:58131472 T/C cg24829409 chr8:58192753 C8orf71 -0.55 -8.03 -0.4 1.71e-14 Developmental language disorder (linguistic errors); CRC cis rs56104184 0.723 rs73063524 chr19:49409004 T/C cg21252483 chr19:49399788 TULP2 -0.42 -6.69 -0.35 9.49e-11 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; CRC cis rs514406 0.861 rs4926932 chr1:53247495 C/T cg24675658 chr1:53192096 ZYG11B 0.56 8.12 0.41 9.29e-15 Monocyte count; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg06713297 chr1:242011104 EXO1 0.46 6.06 0.32 3.78e-9 Thyroid stimulating hormone; CRC cis rs3099143 1.000 rs3106375 chr15:77142243 T/C cg21673338 chr15:77095150 SCAPER -0.7 -7.3 -0.37 2.15e-12 Recalcitrant atopic dermatitis; CRC cis rs6456156 0.819 rs7765739 chr6:167518472 C/T cg07513332 chr6:167530253 CCR6 0.38 6.34 0.33 7.46e-10 Primary biliary cholangitis; CRC cis rs519973 0.554 rs13069721 chr3:187669234 C/A cg10168494 chr3:187635183 NA 0.39 5.71 0.3 2.57e-8 Allergic disease (asthma, hay fever or eczema); CRC cis rs1862618 0.671 rs72644088 chr5:56241019 G/A cg03609598 chr5:56110824 MAP3K1 0.57 7.71 0.39 1.5e-13 Initial pursuit acceleration; CRC cis rs1840108 0.529 rs35192399 chr2:181492583 T/C cg23363182 chr2:181467187 NA -0.48 -6.51 -0.34 2.8e-10 Anti-saccade response; CRC cis rs1348850 0.872 rs13004955 chr2:178398923 A/T cg02961200 chr2:178257176 LOC100130691;AGPS -0.55 -7.83 -0.4 6.97e-14 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs1862618 0.573 rs832532 chr5:56221938 T/C cg20203395 chr5:56204925 C5orf35 -0.76 -9.19 -0.45 4.53e-18 Initial pursuit acceleration; CRC cis rs9443645 0.901 rs9343860 chr6:79739010 G/A cg11833968 chr6:79620685 NA -0.36 -6.1 -0.32 2.99e-9 Intelligence (multi-trait analysis); CRC cis rs875971 0.830 rs6976714 chr7:65891461 G/A cg12463550 chr7:65579703 CRCP 0.51 6.95 0.36 1.95e-11 Aortic root size; CRC cis rs2075371 1.000 rs378358 chr7:133970628 A/G cg11752832 chr7:134001865 SLC35B4 0.48 7.44 0.38 9e-13 Mean platelet volume; CRC cis rs6545883 0.929 rs1900572 chr2:61650715 T/G cg15711740 chr2:61764176 XPO1 0.44 5.91 0.31 8.59e-9 Tuberculosis; CRC cis rs10791323 0.720 rs2851117 chr11:133705905 A/G cg06766960 chr11:133703094 NA 0.41 7.43 0.38 9.56e-13 Childhood ear infection; CRC cis rs1538970 0.924 rs12097497 chr1:45880669 C/T cg05343316 chr1:45956843 TESK2 0.74 10.08 0.49 5.11e-21 Platelet count; CRC trans rs4263408 0.934 rs9683743 chr4:39703194 A/C cg02073318 chr1:41708081 SCMH1 -0.41 -6.06 -0.32 3.77e-9 Plasma amyloid beta peptide concentrations (ABx-40); CRC cis rs12474201 0.928 rs13025984 chr2:46938789 T/C cg06386533 chr2:46925753 SOCS5 0.8 13.18 0.59 3.73e-32 Height; CRC cis rs972578 0.967 rs5759091 chr22:43407464 C/T cg01576275 chr22:43409880 NA -0.47 -7.47 -0.38 7.06e-13 Mean platelet volume; CRC cis rs9527 0.590 rs7894959 chr10:104756182 C/T cg15744005 chr10:104629667 AS3MT -0.31 -6.31 -0.33 8.99e-10 Arsenic metabolism; CRC cis rs7772486 0.686 rs4895684 chr6:146114023 A/C cg23711669 chr6:146136114 FBXO30 -0.68 -11.48 -0.53 7.08e-26 Lobe attachment (rater-scored or self-reported); CRC cis rs875971 0.545 rs10950036 chr7:65818228 G/T cg11764359 chr7:65958608 NA 0.45 5.67 0.3 3.19e-8 Aortic root size; CRC cis rs1018836 0.786 rs10086401 chr8:91572818 C/T cg16814680 chr8:91681699 NA -0.63 -9.77 -0.47 5.92e-20 Ejection fraction in Tripanosoma cruzi seropositivity; CRC cis rs58688157 0.705 rs12800061 chr11:587425 C/A cg14433983 chr11:636460 DRD4 -0.44 -5.61 -0.3 4.26e-8 Systemic lupus erythematosus; CRC cis rs1046896 0.553 rs2292965 chr17:80900645 G/A cg19046167 chr17:80928561 B3GNTL1 0.5 7.1 0.36 7.65e-12 Glycated hemoglobin levels; CRC cis rs12477438 0.798 rs7570657 chr2:99654281 G/C cg14399236 chr2:99771627 LIPT1;TSGA10 -0.6 -8.16 -0.41 7.34e-15 Chronic sinus infection; CRC cis rs7615952 0.932 rs13325495 chr3:125637416 T/G cg05084668 chr3:125655381 ALG1L -0.62 -8.27 -0.41 3.35e-15 Blood pressure (smoking interaction); CRC cis rs736801 0.607 rs11746555 chr5:131727033 G/A cg07395648 chr5:131743802 NA -0.39 -5.67 -0.3 3.15e-8 Breast cancer;Mosquito bite size; CRC cis rs1448094 0.872 rs7313373 chr12:86398370 C/G cg18827107 chr12:86230957 RASSF9 -0.36 -5.7 -0.3 2.65e-8 Major depressive disorder; CRC cis rs2276314 1.000 rs9304154 chr18:33562227 C/T cg19628046 chr18:33552617 C18orf21 0.48 6.31 0.33 9.13e-10 Endometriosis;Drug-induced torsades de pointes; CRC cis rs6952808 0.798 rs28970524 chr7:1927484 C/T cg21782813 chr7:2030301 MAD1L1 0.47 7.96 0.4 2.77e-14 Bipolar disorder and schizophrenia; CRC cis rs2439831 0.867 rs496584 chr15:43831923 C/T cg02155558 chr15:43621948 ADAL;LCMT2 0.71 8.14 0.41 8.5e-15 Lung cancer in ever smokers; CRC trans rs1005277 0.579 rs2474569 chr10:38383491 C/G cg17830980 chr10:43048298 ZNF37B -0.6 -9.93 -0.48 1.67e-20 Extrinsic epigenetic age acceleration; CRC cis rs6502050 0.835 rs4789665 chr17:80168097 A/C cg02741985 chr17:80059408 CCDC57 0.43 7.14 0.37 5.9e-12 Life satisfaction; CRC cis rs2692947 0.644 rs772178 chr2:96963684 C/T cg23100626 chr2:96804247 ASTL -0.28 -7.14 -0.37 6.1e-12 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; CRC cis rs7618501 0.633 rs35065728 chr3:50009176 T/C cg24308560 chr3:49941425 MST1R -0.54 -9.04 -0.45 1.34e-17 Intelligence (multi-trait analysis); CRC cis rs11098499 0.754 rs2964 chr4:120240131 T/C cg24375607 chr4:120327624 NA 0.48 7.64 0.39 2.32e-13 Corneal astigmatism; CRC cis rs1799949 0.965 rs9646413 chr17:41426157 A/G cg25072359 chr17:41440525 NA 0.52 8.12 0.41 9.33e-15 Menopause (age at onset); CRC cis rs4638749 0.677 rs2219082 chr2:108854182 C/A cg25838818 chr2:108905173 SULT1C2 -0.34 -5.63 -0.3 3.93e-8 Blood pressure; CRC cis rs7107174 0.681 rs10899499 chr11:78124797 A/G cg02023728 chr11:77925099 USP35 -0.41 -6.44 -0.33 4.29e-10 Testicular germ cell tumor; CRC cis rs6089584 0.888 rs6061982 chr20:60620673 C/T cg23262073 chr20:60523788 NA -0.46 -7.11 -0.36 7.38e-12 Body mass index; CRC cis rs7772486 0.875 rs6914813 chr6:146397798 A/G cg23711669 chr6:146136114 FBXO30 0.66 11.56 0.54 3.46e-26 Lobe attachment (rater-scored or self-reported); CRC cis rs155076 1.000 rs567166 chr13:21837519 T/C cg21970626 chr13:21893289 NA 0.46 5.94 0.31 7.09e-9 White matter hyperintensity burden; CRC cis rs11792861 0.962 rs3750452 chr9:111801353 T/C cg05043794 chr9:111880884 C9orf5 -0.34 -6.34 -0.33 7.75e-10 Menarche (age at onset); CRC cis rs72781680 0.821 rs2176265 chr2:24158638 C/G cg08917208 chr2:24149416 ATAD2B 0.56 6.79 0.35 5.28e-11 Lymphocyte counts; CRC cis rs344364 0.518 rs1657129 chr16:1945826 G/A cg09830162 chr16:1889614 FAHD1;C16orf73 -0.74 -9.05 -0.45 1.3e-17 Glomerular filtration rate in chronic kidney disease; CRC cis rs13108904 0.901 rs6826029 chr4:1307689 A/G cg02018176 chr4:1364513 KIAA1530 0.4 6.73 0.35 7.47e-11 Obesity-related traits; CRC cis rs9811920 0.809 rs35422475 chr3:99711545 G/A cg07805332 chr3:99536008 MIR548G;C3orf26 0.39 6.0 0.31 5.23e-9 Axial length; CRC trans rs116095464 0.558 rs28558836 chr5:285748 C/G cg00938859 chr5:1591904 SDHAP3 0.66 7.27 0.37 2.68e-12 Breast cancer; CRC cis rs742115 0.510 rs9468839 chr6:11308035 A/T cg25250968 chr6:11318770 NEDD9 0.38 7.27 0.37 2.63e-12 Coronary artery disease; CRC cis rs798554 0.759 rs2644309 chr7:2889034 T/C cg13628971 chr7:2884303 GNA12 0.61 8.13 0.41 9.02e-15 Height; CRC cis rs861020 0.771 rs661849 chr1:210001233 C/T cg05527609 chr1:210001259 C1orf107 1.04 14.1 0.61 1.17e-35 Orofacial clefts; CRC cis rs4862750 0.914 rs11945845 chr4:187874136 T/C cg11301795 chr4:187892539 NA -0.83 -18.14 -0.71 1.79e-51 Lobe attachment (rater-scored or self-reported); CRC cis rs6860806 0.507 rs273901 chr5:131694360 G/T cg18301423 chr5:131593218 PDLIM4 0.39 6.46 0.34 3.77e-10 Breast cancer; CRC cis rs644799 1.000 rs12291986 chr11:95523030 T/G cg25622487 chr11:95524042 FAM76B;CEP57 0.76 11.89 0.55 2.32e-27 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs7618915 0.571 rs12487445 chr3:52618319 A/C cg05573699 chr3:52720067 GNL3;PBRM1 -0.44 -6.21 -0.32 1.63e-9 Bipolar disorder; CRC cis rs67311347 1.000 rs11715214 chr3:40403004 C/A cg09455208 chr3:40491958 NA 0.44 8.82 0.44 6.83e-17 Renal cell carcinoma; CRC cis rs9549367 0.789 rs57747440 chr13:113894750 C/A cg18105134 chr13:113819100 PROZ -0.71 -10.34 -0.5 7.19e-22 Platelet distribution width; CRC cis rs950169 0.800 rs34302901 chr15:85110943 C/G cg17507749 chr15:85114479 UBE2QP1 0.67 10.36 0.5 5.72e-22 Schizophrenia; CRC cis rs9039 1.000 rs17652208 chr16:9196463 C/T cg08831531 chr16:9218945 NA -0.56 -6.66 -0.34 1.13e-10 Menopause (age at onset); CRC cis rs9649213 0.613 rs10953256 chr7:97951886 G/C cg00277769 chr7:97922759 BAIAP2L1 -0.61 -10.7 -0.51 4.06e-23 Prostate cancer (SNP x SNP interaction); CRC cis rs6748734 0.901 rs6720357 chr2:241830296 A/C cg07537917 chr2:241836409 C2orf54 -0.21 -6.03 -0.32 4.52e-9 Urinary metabolites; CRC cis rs1011108 1.000 rs1011108 chr2:26782621 A/G cg18742855 chr2:26800399 C2orf70 -0.48 -7.28 -0.37 2.42e-12 Periodontal microbiota; CRC cis rs9611565 0.512 rs4822052 chr22:42193741 G/A cg06634786 chr22:41940651 POLR3H -0.63 -7.29 -0.37 2.37e-12 Vitiligo; CRC cis rs765787 0.505 rs11630884 chr15:45532246 C/T cg24006582 chr15:45444508 DUOX1 -0.54 -8.29 -0.42 2.94e-15 Uric acid levels; CRC cis rs2281845 0.826 rs4915215 chr1:201077212 C/T cg24849736 chr1:201084428 NA -0.61 -11.23 -0.53 5.39e-25 Permanent tooth development; CRC cis rs11122272 0.735 rs2749704 chr1:231526243 A/G cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.54 -8.14 -0.41 7.99e-15 Hemoglobin concentration; CRC cis rs6502050 0.731 rs9891378 chr17:80116035 T/C cg11859384 chr17:80120422 CCDC57 -0.37 -5.98 -0.31 5.86e-9 Life satisfaction; CRC cis rs1499614 1.000 rs2707838 chr7:66159201 C/T cg18252515 chr7:66147081 NA -1.24 -14.6 -0.63 1.48e-37 Gout; CRC cis rs9457247 0.967 rs2149084 chr6:167370988 G/C cg23791538 chr6:167370224 RNASET2 0.39 5.98 0.31 5.67e-9 Crohn's disease; CRC cis rs1443512 0.812 rs1992563 chr12:54330441 G/T cg17410650 chr12:54324560 NA -0.37 -6.69 -0.35 9.45e-11 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for BMI in non-smokers;Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction);Waist-hip ratio;Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour); CRC cis rs7811142 1.000 rs6975514 chr7:100056220 T/C cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.17 17.51 0.69 5.94e-49 Platelet count; CRC cis rs12971120 0.947 rs3764509 chr18:72167124 C/G cg25817165 chr18:72167213 CNDP2 -0.67 -11.67 -0.54 1.46e-26 Refractive error; CRC cis rs7680126 0.633 rs11729318 chr4:10336919 G/C cg00071950 chr4:10020882 SLC2A9 -0.46 -6.11 -0.32 2.78e-9 Urate levels in lean individuals;Urate levels in overweight individuals;Urate levels in obese individuals; CRC cis rs4713118 0.784 rs9468219 chr6:27731755 C/A cg26587870 chr6:27730563 NA -0.46 -6.82 -0.35 4.26e-11 Parkinson's disease; CRC cis rs2859741 1.000 rs4653239 chr1:37509872 C/G cg09363841 chr1:37513479 NA 0.62 11.34 0.53 2.27e-25 Forced expiratory volume in 1 second (environmental tobacco smoke interaction); CRC cis rs910316 0.712 rs175074 chr14:75504454 G/A cg11812906 chr14:75593930 NEK9 -0.57 -8.95 -0.44 2.75e-17 Height; CRC cis rs6545883 0.929 rs1186707 chr2:61673520 C/A cg15711740 chr2:61764176 XPO1 -0.42 -5.67 -0.3 3.18e-8 Tuberculosis; CRC cis rs3793683 0.556 rs2803989 chr10:134560596 C/T cg26818010 chr10:134567672 INPP5A -0.53 -7.58 -0.39 3.44e-13 Migraine; CRC cis rs6088580 0.634 rs6142159 chr20:32993035 G/A cg08999081 chr20:33150536 PIGU -0.62 -11.47 -0.53 7.71e-26 Glomerular filtration rate (creatinine); CRC cis rs6582630 0.559 rs12318620 chr12:38522340 T/C cg26384229 chr12:38710491 ALG10B -0.53 -7.75 -0.39 1.12e-13 Drug-induced liver injury (flucloxacillin); CRC cis rs7107174 1.000 rs11603112 chr11:78073491 G/A cg02023728 chr11:77925099 USP35 0.5 8.79 0.44 8.61e-17 Testicular germ cell tumor; CRC cis rs10504229 1.000 rs67630725 chr8:58185580 G/A cg02725872 chr8:58115012 NA -0.38 -6.43 -0.33 4.44e-10 Developmental language disorder (linguistic errors); CRC cis rs763121 0.853 rs2267393 chr22:39101619 G/C cg06022373 chr22:39101656 GTPBP1 0.82 13.45 0.6 3.74e-33 Menopause (age at onset); CRC cis rs3087591 0.960 rs9896041 chr17:29571326 C/G cg24425628 chr17:29625626 OMG;NF1 -0.86 -16.79 -0.68 4.09e-46 Hip circumference; CRC trans rs10838798 0.504 rs1483123 chr11:48326773 G/A cg03929089 chr4:120376271 NA -0.47 -6.7 -0.35 9.18e-11 Height; CRC cis rs56235845 0.694 rs11749830 chr5:176766547 G/A cg05207973 chr5:176823642 SLC34A1 0.34 5.87 0.31 1.08e-8 Hemoglobin concentration;Hematocrit; CRC cis rs616402 0.527 rs589151 chr1:10567711 C/T cg17425144 chr1:10567563 PEX14 0.59 13.49 0.6 2.67e-33 Breast size; CRC cis rs55665837 1.000 rs11023223 chr11:14457112 A/G cg19336497 chr11:14380999 RRAS2 -0.39 -6.64 -0.34 1.3100000000000001e-10 Vitamin D levels; CRC cis rs7618915 0.571 rs2289249 chr3:52597664 G/A cg11645453 chr3:52864694 ITIH4 0.35 6.11 0.32 2.81e-9 Bipolar disorder; CRC cis rs9549367 0.713 rs3024756 chr13:113822950 G/C cg18105134 chr13:113819100 PROZ -0.85 -12.89 -0.58 4.77e-31 Platelet distribution width; CRC cis rs2576037 0.526 rs998819 chr18:44564181 C/T cg23996704 chr18:44553084 KATNAL2 0.41 8.2 0.41 5.47e-15 Personality dimensions; CRC cis rs172166 0.637 rs1225595 chr6:28151340 A/T cg15845792 chr6:28175446 NA 0.86 13.37 0.59 7.62e-33 Cardiac Troponin-T levels; CRC cis rs3741404 0.560 rs12362602 chr11:63908660 G/A cg05016508 chr11:63871570 FLRT1;MACROD1 -0.37 -5.77 -0.3 1.86e-8 Platelet count; CRC cis rs853679 0.517 rs3734573 chr6:28059437 T/C cg03623178 chr6:28175578 NA 0.96 12.48 0.57 1.62e-29 Depression; CRC cis rs72781680 0.898 rs72780188 chr2:24006065 G/A cg08917208 chr2:24149416 ATAD2B 0.84 8.11 0.41 1e-14 Lymphocyte counts; CRC cis rs2455601 0.744 rs11042133 chr11:8966511 A/C cg09997546 chr11:8931473 C11orf17;ST5 -0.52 -6.9 -0.36 2.69e-11 Schizophrenia; CRC cis rs2120019 1.000 rs2415253 chr15:75375699 A/G cg11632617 chr15:75315747 PPCDC -0.56 -7.9 -0.4 4.2e-14 Blood trace element (Zn levels); CRC cis rs2073300 0.609 rs6137907 chr20:23344511 C/T cg12062639 chr20:23401060 NAPB 0.68 6.1 0.32 3.04e-9 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs2251381 0.778 rs2471947 chr21:30534219 G/T cg24692254 chr21:30365293 RNF160 0.74 12.19 0.56 1.84e-28 Selective IgA deficiency; CRC trans rs6550704 0.687 rs9865314 chr3:22634337 A/G cg19545348 chr1:211434133 RCOR3 -0.4 -5.96 -0.31 6.43e-9 Daytime sleep phenotypes; CRC cis rs1448094 0.512 rs56082822 chr12:86255475 C/T cg25456477 chr12:86230367 RASSF9 0.33 5.78 0.3 1.69e-8 Major depressive disorder; CRC cis rs9325144 0.647 rs12227834 chr12:38849246 G/C cg26384229 chr12:38710491 ALG10B -0.51 -7.3 -0.37 2.23e-12 Morning vs. evening chronotype; CRC cis rs2019137 0.901 rs4849176 chr2:113977936 C/T cg07772999 chr2:113993052 PAX8;LOC440839;LOC654433 -0.43 -6.13 -0.32 2.52e-9 Lymphocyte counts; CRC trans rs7726839 0.540 rs57306627 chr5:597643 T/C cg11887960 chr12:57824829 NA 0.59 6.68 0.35 1.01e-10 Obesity-related traits; CRC cis rs7647973 1.000 rs13322887 chr3:49555583 G/A cg20833759 chr3:49053208 WDR6;DALRD3 -0.54 -8.04 -0.41 1.69e-14 Menarche (age at onset); CRC cis rs6502050 0.734 rs9674631 chr17:80096525 A/G cg19223190 chr17:80058835 NA 0.4 6.31 0.33 8.92e-10 Life satisfaction; CRC cis rs861020 0.606 rs629224 chr1:210005071 C/T cg09163369 chr1:210001066 C1orf107 0.44 6.4 0.33 5.35e-10 Orofacial clefts; CRC cis rs990171 0.955 rs6761825 chr2:103075561 T/C cg03938978 chr2:103052716 IL18RAP 0.46 5.87 0.31 1.09e-8 Lymphocyte counts; CRC cis rs7119 0.717 rs11639293 chr15:77810845 T/C cg27398640 chr15:77910606 LINGO1 -0.44 -7.61 -0.39 2.96e-13 Type 2 diabetes; CRC cis rs4604732 0.754 rs12080212 chr1:247631606 T/C cg02104434 chr1:247694406 LOC148824;OR2C3 0.39 6.42 0.33 4.63e-10 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CRC cis rs3764563 1.000 rs4808326 chr19:15726147 A/G cg20725493 chr19:15740067 CYP4F8 -0.7 -6.51 -0.34 2.89e-10 Inflammatory biomarkers; CRC cis rs883565 0.569 rs704959 chr3:39180263 G/A cg01426195 chr3:39028469 NA 0.41 6.7 0.35 9.13e-11 Handedness; CRC trans rs561341 1.000 rs506766 chr17:30289659 T/C cg20587970 chr11:113659929 NA -1.44 -19.26 -0.73 6.97e-56 Hip circumference adjusted for BMI; CRC trans rs2243480 1.000 rs1499613 chr7:65730860 G/A cg10756647 chr7:56101905 PSPH -0.77 -7.87 -0.4 5.06e-14 Diabetic kidney disease; CRC cis rs7647973 0.677 rs11130211 chr3:49645209 C/T cg03060546 chr3:49711283 APEH 0.64 7.54 0.38 4.52e-13 Menarche (age at onset); CRC cis rs7605827 0.930 rs4668919 chr2:15662171 C/T cg19274914 chr2:15703543 NA 0.37 5.71 0.3 2.52e-8 Educational attainment (years of education); CRC cis rs6963495 0.818 rs73192115 chr7:105169605 T/A cg02135003 chr7:105160482 PUS7 -0.92 -12.46 -0.57 1.94e-29 Bipolar disorder (body mass index interaction); CRC cis rs9649213 0.614 rs9640655 chr7:98017099 G/A cg09267113 chr7:98030324 BAIAP2L1 -0.94 -12.65 -0.57 3.73e-30 Prostate cancer (SNP x SNP interaction); CRC cis rs66569888 0.523 rs4522599 chr2:106926004 G/C cg16099169 chr2:106886729 NA 0.59 9.2 0.45 4.28e-18 Facial morphology (factor 23); CRC trans rs7726839 0.540 rs11739847 chr5:609661 G/A cg11887960 chr12:57824829 NA 0.58 6.5 0.34 3.04e-10 Obesity-related traits; CRC cis rs12134245 0.776 rs61548854 chr1:92001536 C/T cg25838465 chr1:92012736 NA -0.68 -12.62 -0.57 4.58e-30 Breast cancer; CRC cis rs7662987 0.517 rs2602876 chr4:100039535 A/T cg12011299 chr4:100065546 ADH4 0.5 9.49 0.46 4.72e-19 Smoking initiation; CRC cis rs17162190 0.698 rs6693662 chr1:26821230 A/G cg17456097 chr1:26900765 RPS6KA1 0.45 6.51 0.34 2.79e-10 Mean corpuscular volume; CRC cis rs9486719 0.895 rs3734239 chr6:96996244 A/G cg06623918 chr6:96969491 KIAA0776 -0.82 -9.56 -0.47 2.8e-19 Migraine;Coronary artery disease; CRC cis rs7584330 0.554 rs7571100 chr2:238435305 G/T cg14458575 chr2:238380390 NA 0.52 6.86 0.35 3.51e-11 Prostate cancer; CRC trans rs877282 0.842 rs7092986 chr10:756373 G/A cg22713356 chr15:30763199 NA 1.19 13.88 0.61 8.17e-35 Uric acid levels; CRC cis rs1728785 1.000 rs3203684 chr16:68600440 C/T cg02972257 chr16:68554789 NA 0.59 7.33 0.37 1.8e-12 Ulcerative colitis; CRC cis rs11123170 0.529 rs35606997 chr2:113973350 G/A cg21550016 chr2:113992930 PAX8;LOC440839;LOC654433 0.48 5.92 0.31 8.01e-9 Renal function-related traits (BUN); CRC trans rs9291683 0.530 rs882223 chr4:9981625 A/C cg26043149 chr18:55253948 FECH 0.54 8.27 0.41 3.27e-15 Bone mineral density; CRC cis rs6951245 1.000 rs78861357 chr7:1095418 C/T cg24642844 chr7:1081250 C7orf50 -0.78 -9.44 -0.46 7.23e-19 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs2153535 0.580 rs6914276 chr6:8450435 A/T cg07606381 chr6:8435919 SLC35B3 -0.66 -10.63 -0.51 6.76e-23 Motion sickness; CRC trans rs7615952 0.932 rs6438948 chr3:125650045 A/T cg02007433 chr3:129722099 NA 0.46 6.55 0.34 2.28e-10 Blood pressure (smoking interaction); CRC cis rs9818758 0.607 rs34580506 chr3:49113713 C/A cg07636037 chr3:49044803 WDR6 -0.82 -6.67 -0.35 1.06e-10 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; CRC cis rs1799949 1.000 rs8176220 chr17:41222462 A/G cg23758822 chr17:41437982 NA 0.81 13.64 0.6 7.09e-34 Menopause (age at onset); CRC cis rs6831352 0.918 rs13127582 chr4:100058194 G/A cg13256891 chr4:100009986 ADH5 -0.65 -8.84 -0.44 5.89e-17 Alcohol dependence; CRC cis rs72901758 0.768 rs72901762 chr17:76244926 A/G cg26068271 chr17:76253126 NA 0.38 5.74 0.3 2.12e-8 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells; CRC cis rs881375 0.933 rs7031096 chr9:123694942 T/C cg09586646 chr9:123605570 PSMD5;LOC253039 0.47 6.49 0.34 3.18e-10 Rheumatoid arthritis; CRC cis rs7937682 0.889 rs490199 chr11:111487890 A/G cg19812747 chr11:111475976 SIK2 -0.58 -9.92 -0.48 1.8e-20 Primary sclerosing cholangitis; CRC cis rs6912958 0.781 rs9450739 chr6:88268271 G/A cg08069147 chr6:88032118 GJB7;C6orf162 -0.56 -8.43 -0.42 1.12e-15 Monocyte percentage of white cells; CRC cis rs10504229 0.683 rs7822631 chr8:58130916 C/G cg24829409 chr8:58192753 C8orf71 -0.55 -8.03 -0.4 1.71e-14 Developmental language disorder (linguistic errors); CRC cis rs8180040 0.934 rs4858811 chr3:47480524 G/C cg27129171 chr3:47204927 SETD2 -0.59 -9.11 -0.45 8.18e-18 Colorectal cancer; CRC cis rs1707322 0.752 rs4660880 chr1:46111040 C/T cg06784218 chr1:46089804 CCDC17 0.65 12.5 0.57 1.37e-29 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs35306767 0.903 rs12250936 chr10:870109 C/T cg20503657 chr10:835505 NA 0.91 11.32 0.53 2.52e-25 Eosinophil percentage of granulocytes; CRC trans rs12699921 0.632 rs2691594 chr7:17864816 C/G cg02066331 chr6:17282778 RBM24 -0.36 -6.09 -0.32 3.23e-9 Fibrinogen levels; CRC cis rs875971 0.660 rs6460308 chr7:66084740 T/C cg11764359 chr7:65958608 NA -0.54 -8.25 -0.41 3.88e-15 Aortic root size; CRC cis rs7605827 0.930 rs4668900 chr2:15511740 T/C cg19274914 chr2:15703543 NA 0.38 5.8 0.3 1.59e-8 Educational attainment (years of education); CRC cis rs6735179 1.000 rs6735179 chr2:1777150 A/G cg19300414 chr2:1746591 PXDN 0.36 6.28 0.33 1.05e-9 Response to antipsychotic treatment; CRC cis rs524281 0.861 rs11227426 chr11:65971951 T/C cg16950941 chr11:66035639 RAB1B -0.6 -7.3 -0.37 2.21e-12 Electroencephalogram traits; CRC cis rs7772486 0.875 rs2224120 chr6:146343280 A/C cg23711669 chr6:146136114 FBXO30 0.67 11.53 0.54 4.5e-26 Lobe attachment (rater-scored or self-reported); CRC cis rs4474465 0.646 rs10793334 chr11:78278792 C/T cg02023728 chr11:77925099 USP35 0.32 5.62 0.3 4e-8 Alzheimer's disease (survival time); CRC cis rs4975709 0.569 rs1684965 chr5:1865248 A/G cg14773178 chr5:1868261 NA 0.38 6.79 0.35 5.25e-11 Cardiovascular disease risk factors; CRC cis rs1840108 0.543 rs13020426 chr2:181345771 T/C cg23363182 chr2:181467187 NA -0.56 -6.59 -0.34 1.72e-10 Anti-saccade response; CRC cis rs4665809 1.000 rs6546726 chr2:26275116 A/G cg25036284 chr2:26402008 FAM59B -0.46 -6.02 -0.32 4.57e-9 Gut microbiome composition (summer); CRC cis rs9443645 0.869 rs11754419 chr6:79729648 A/G cg05283184 chr6:79620031 NA -0.63 -9.98 -0.48 1.17e-20 Intelligence (multi-trait analysis); CRC cis rs9322193 0.884 rs9397036 chr6:150172923 C/T cg13206674 chr6:150067644 NUP43 0.58 8.17 0.41 6.65e-15 Lung cancer; CRC cis rs7412746 0.611 rs3768018 chr1:150723747 T/C cg10589385 chr1:150898437 SETDB1 0.3 6.16 0.32 2.14e-9 Melanoma; CRC cis rs9611565 0.694 rs2142505 chr22:41820541 A/G cg06634786 chr22:41940651 POLR3H 0.7 7.85 0.4 6.01e-14 Vitiligo; CRC cis rs9393692 0.676 rs806977 chr6:26189615 A/G cg00631329 chr6:26305371 NA -0.59 -10.45 -0.5 2.81e-22 Educational attainment; CRC cis rs2797160 0.967 rs984041 chr6:126021328 A/T cg05901451 chr6:126070800 HEY2 0.39 6.04 0.32 4.14e-9 Endometrial cancer; CRC cis rs883565 0.525 rs9833327 chr3:39029631 A/G cg01426195 chr3:39028469 NA -0.52 -8.34 -0.42 2.13e-15 Handedness; CRC cis rs6896969 0.510 rs1899982 chr5:40425045 C/T cg09067459 chr5:40385259 NA 0.47 7.9 0.4 4.19e-14 Multiple sclerosis; CRC trans rs9291683 0.588 rs34501273 chr4:9996996 C/T cg26043149 chr18:55253948 FECH 0.49 7.77 0.39 9.81e-14 Bone mineral density; CRC cis rs17818399 0.547 rs4952833 chr2:46762034 T/C cg21681030 chr2:46777652 RHOQ 0.45 6.05 0.32 3.98e-9 Height; CRC cis rs1552244 1.000 rs17032276 chr3:10076975 A/C cg13047869 chr3:10149882 C3orf24 0.57 7.76 0.39 1.1e-13 Alzheimer's disease; CRC cis rs7705042 0.826 rs13184323 chr5:141494719 T/G cg07392085 chr5:141489673 NDFIP1 0.47 7.41 0.38 1.06e-12 Asthma; CRC trans rs2228479 0.850 rs11644213 chr16:89837367 C/T cg21302420 chr1:112162376 RAP1A -0.71 -6.0 -0.31 5.24e-9 Skin colour saturation; CRC cis rs7534824 0.543 rs12569174 chr1:101386179 A/G cg16556008 chr1:101360663 SLC30A7;EXTL2 0.55 5.72 0.3 2.37e-8 Refractive astigmatism; CRC cis rs3931020 0.548 rs17618340 chr1:75247617 G/A cg17719053 chr1:75198211 TYW3;CRYZ 0.43 5.96 0.31 6.64e-9 Resistin levels; CRC cis rs951366 0.789 rs823152 chr1:205736285 G/A cg14159672 chr1:205819179 PM20D1 0.77 11.31 0.53 2.93e-25 Menarche (age at onset); CRC trans rs263156 0.727 rs7740440 chr6:142972917 A/G cg26361513 chr14:105821007 PACS2 0.4 6.11 0.32 2.82e-9 Ear morphology;Lobe size;Lobe attachment; CRC cis rs2019137 0.560 rs7578633 chr2:113978650 C/T cg07772999 chr2:113993052 PAX8;LOC440839;LOC654433 0.58 8.51 0.42 6.24e-16 Lymphocyte counts; CRC cis rs9322193 0.962 rs9478848 chr6:150146216 G/T cg07701084 chr6:150067640 NUP43 0.46 6.49 0.34 3.14e-10 Lung cancer; CRC cis rs896854 0.552 rs2515236 chr8:95934907 A/G cg13393036 chr8:95962371 TP53INP1 0.44 6.66 0.34 1.13e-10 Type 2 diabetes; CRC cis rs12286929 0.556 rs11605461 chr11:115053011 C/T cg04055981 chr11:115044050 NA -0.36 -5.65 -0.3 3.48e-8 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs611744 0.647 rs864166 chr8:109249300 C/G cg21045802 chr8:109455806 TTC35 0.42 6.68 0.35 1.05e-10 Dupuytren's disease; CRC trans rs6762477 0.748 rs11711407 chr3:50225029 A/G cg21665057 chr3:196295764 WDR53;FBXO45 -0.42 -6.42 -0.33 4.7e-10 Menarche (age at onset); CRC cis rs2882667 0.858 rs11242448 chr5:138443154 C/A cg04439458 chr5:138467593 SIL1 -0.36 -5.99 -0.31 5.5e-9 Age-related hearing impairment (SNP x SNP interaction); CRC trans rs890448 0.896 rs9884436 chr4:102413271 A/G cg24678611 chr1:3567732 TP73;WDR8 -0.28 -6.01 -0.31 4.84e-9 Acute urticaria and angioedema (non-steroidal anti-inflammatory drug-induced); CRC cis rs58688157 0.705 rs7928902 chr11:609068 G/A cg07212818 chr11:638076 DRD4 -0.43 -5.61 -0.3 4.24e-8 Systemic lupus erythematosus; CRC cis rs10512697 0.803 rs13173352 chr5:3578681 A/G cg19473799 chr5:3511975 NA -0.73 -5.8 -0.3 1.53e-8 Immune response to smallpox vaccine (IL-6); CRC cis rs6499255 0.904 rs9929720 chr16:69557096 C/T cg04110750 chr16:69646130 NFAT5 0.54 7.86 0.4 5.64e-14 IgE levels; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg06477881 chr10:72142520 LRRC20 0.41 6.22 0.32 1.52e-9 Intelligence (multi-trait analysis); CRC cis rs4824093 0.610 rs73443923 chr22:50285348 C/T cg22709217 chr22:50311962 ALG12;CRELD2 -1.02 -7.76 -0.39 1.09e-13 Amyotrophic lateral sclerosis (sporadic); CRC cis rs17095355 1.000 rs11194920 chr10:111695412 G/T cg00817464 chr10:111662876 XPNPEP1 -0.59 -7.78 -0.39 9.34e-14 Biliary atresia; CRC cis rs11190604 1.000 rs12354411 chr10:102294537 G/A cg07080220 chr10:102295463 HIF1AN 0.47 5.66 0.3 3.31e-8 Palmitoleic acid (16:1n-7) levels; CRC cis rs4332037 0.901 rs7791899 chr7:1935988 T/C cg25834613 chr7:1915315 MAD1L1 -0.44 -6.4 -0.33 5.26e-10 Bipolar disorder; CRC cis rs6502050 0.835 rs9674648 chr17:80096756 A/G cg19223190 chr17:80058835 NA 0.38 6.17 0.32 1.97e-9 Life satisfaction; CRC cis rs1691799 0.899 rs2951656 chr12:66732273 T/G cg16791601 chr12:66731901 HELB -0.68 -11.49 -0.54 6.43e-26 White blood cell count (basophil); CRC cis rs2836950 0.561 rs34705151 chr21:40553344 G/A cg06238570 chr21:40685208 BRWD1 -0.62 -9.05 -0.45 1.28e-17 Menarche (age at onset); CRC cis rs13256369 0.802 rs1060106 chr8:8561452 A/G cg06636001 chr8:8085503 FLJ10661 0.48 6.1 0.32 2.99e-9 Obesity-related traits; CRC cis rs904251 0.523 rs2797798 chr6:37481437 C/T cg01843034 chr6:37503916 NA -0.44 -8.26 -0.41 3.64e-15 Cognitive performance; CRC cis rs2456568 0.867 rs2511375 chr11:93671117 T/G cg26875233 chr11:93583750 C11orf90 -0.34 -6.59 -0.34 1.7e-10 Response to serotonin reuptake inhibitors in major depressive disorder; CRC cis rs1538970 0.816 rs12029322 chr1:45970446 C/T cg05343316 chr1:45956843 TESK2 0.75 9.79 0.48 4.94e-20 Platelet count; CRC cis rs2732480 0.577 rs2732457 chr12:48758379 A/G cg24011408 chr12:48396354 COL2A1 -0.46 -6.3 -0.33 9.82e-10 Hemoglobin concentration;Red blood cell count;Hematocrit; CRC cis rs35306767 0.761 rs34480046 chr10:1027440 A/G cg26597838 chr10:835615 NA 0.95 10.61 0.5 8.04e-23 Eosinophil percentage of granulocytes; CRC cis rs17253792 0.822 rs12100949 chr14:56040787 T/C cg01858014 chr14:56050164 KTN1 -0.83 -7.34 -0.38 1.7e-12 Putamen volume; CRC cis rs1008375 0.863 rs10003291 chr4:17600728 A/C cg16339924 chr4:17578868 LAP3 0.58 7.22 0.37 3.7e-12 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs1448094 0.967 rs7313443 chr12:86332940 G/A cg19622623 chr12:86230825 RASSF9 -0.35 -5.69 -0.3 2.8e-8 Major depressive disorder; CRC cis rs9527 0.590 rs11191578 chr10:104902337 A/T cg04362960 chr10:104952993 NT5C2 0.6 8.32 0.42 2.32e-15 Arsenic metabolism; CRC cis rs11585357 0.895 rs72633806 chr1:17617943 A/G cg08277548 chr1:17600880 PADI3 -0.89 -11.28 -0.53 3.61e-25 Hair shape; CRC trans rs1656966 1.000 rs1656966 chr3:186466252 C/T cg00546594 chr21:35287829 ATP5O 0.4 6.09 0.32 3.08e-9 Myopia (pathological); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg11044724 chr2:7005733 CMPK2 0.44 6.58 0.34 1.81e-10 Intelligence (multi-trait analysis); CRC cis rs4824093 0.610 rs73443986 chr22:50321193 C/T cg22709217 chr22:50311962 ALG12;CRELD2 -0.99 -9.16 -0.45 5.66e-18 Amyotrophic lateral sclerosis (sporadic); CRC trans rs9822411 0.623 rs17016187 chr3:25364289 A/G cg18451114 chr1:38511677 POU3F1 0.5 6.46 0.34 3.69e-10 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; CRC cis rs9322193 0.962 rs9322219 chr6:150103399 C/T cg07701084 chr6:150067640 NUP43 0.47 6.72 0.35 8.19e-11 Lung cancer; CRC cis rs2066819 1.000 rs17118403 chr12:56630067 C/T cg26714650 chr12:56694279 CS -1.42 -11.61 -0.54 2.3e-26 Psoriasis vulgaris; CRC cis rs10905065 0.827 rs7089100 chr10:5849877 C/G cg11519256 chr10:5708881 ASB13 0.46 6.76 0.35 6.38e-11 Menopause (age at onset); CRC trans rs875971 0.545 rs6460281 chr7:65681115 A/C cg02869306 chr7:64672164 INTS4L1 -0.44 -6.33 -0.33 7.99e-10 Aortic root size; CRC cis rs4728302 0.869 rs6978170 chr7:133603838 C/T cg10665199 chr7:133106180 EXOC4 0.38 5.67 0.3 3.13e-8 Intelligence;Intelligence (multi-trait analysis); CRC cis rs1552244 0.882 rs9757159 chr3:10039166 C/T cg13047869 chr3:10149882 C3orf24 0.51 6.97 0.36 1.74e-11 Alzheimer's disease; CRC cis rs35306767 0.668 rs12356612 chr10:1055055 C/T cg20503657 chr10:835505 NA 0.88 10.71 0.51 3.7e-23 Eosinophil percentage of granulocytes; CRC cis rs7618915 0.547 rs2164884 chr3:52629633 C/T cg15147215 chr3:52552868 STAB1 -0.62 -10.17 -0.49 2.64e-21 Bipolar disorder; CRC cis rs1843834 0.898 rs2014887 chr2:225520082 A/G cg22455342 chr2:225449267 CUL3 0.44 6.02 0.31 4.78e-9 IgE levels in asthmatics (D.p. specific); CRC cis rs728616 0.510 rs7074356 chr10:82191334 C/T cg05935833 chr10:81318306 SFTPA2 -0.43 -6.05 -0.32 4.01e-9 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs9309473 1.000 rs13431267 chr2:73782200 A/G cg20560298 chr2:73613845 ALMS1 -0.48 -5.96 -0.31 6.5e-9 Metabolite levels; CRC cis rs7727544 1.000 rs7727544 chr5:131590534 C/T cg18301423 chr5:131593218 PDLIM4 0.31 5.93 0.31 7.79e-9 Blood metabolite levels; CRC cis rs13082711 0.522 rs9310842 chr3:27369765 A/T cg02860705 chr3:27208620 NA -0.54 -7.95 -0.4 3.04e-14 Systolic blood pressure;Diastolic blood pressure;Blood pressure; CRC cis rs6952808 0.792 rs4421257 chr7:1955152 T/C cg04267008 chr7:1944627 MAD1L1 -0.76 -11.88 -0.55 2.4200000000000002e-27 Bipolar disorder and schizophrenia; CRC cis rs10504229 1.000 rs78953746 chr8:58170608 A/G cg02290350 chr8:58132656 NA -0.42 -5.97 -0.31 5.99e-9 Developmental language disorder (linguistic errors); CRC cis rs7811142 0.830 rs11761426 chr7:99956893 A/T cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.94 12.66 0.57 3.42e-30 Platelet count; CRC cis rs7917772 0.604 rs4917977 chr10:104363119 C/T cg11453585 chr10:104263688 ACTR1A;SUFU 0.82 15.29 0.64 3.08e-40 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC trans rs9914544 0.564 rs7223173 chr17:18805887 A/G cg21372672 chr17:16614065 CCDC144A -0.38 -6.04 -0.32 4.16e-9 Educational attainment (years of education); CRC cis rs116095464 0.558 rs9654452 chr5:299561 C/T cg22496380 chr5:211416 CCDC127 -0.89 -9.98 -0.48 1.14e-20 Breast cancer; CRC cis rs1003719 0.680 rs767998 chr21:38525652 T/G cg10648535 chr21:38446584 PIGP;TTC3 -0.48 -6.68 -0.35 1.03e-10 Eye color traits; CRC cis rs9372498 0.536 rs62424195 chr6:118812108 T/A cg15382696 chr6:118971807 C6orf204 0.62 8.05 0.41 1.53e-14 Diastolic blood pressure; CRC cis rs11997175 0.583 rs56045827 chr8:33787015 G/A cg04338863 chr8:33670619 NA 0.42 6.33 0.33 7.99e-10 Body mass index; CRC cis rs274567 0.501 rs2631368 chr5:131705297 T/G cg18301423 chr5:131593218 PDLIM4 -0.41 -7.02 -0.36 1.3e-11 Blood metabolite levels; CRC cis rs748404 0.697 rs471122 chr15:43558574 C/T cg02155558 chr15:43621948 ADAL;LCMT2 -0.39 -5.74 -0.3 2.19e-8 Lung cancer; CRC cis rs9916302 0.904 rs8079355 chr17:37473018 G/A cg07936489 chr17:37558343 FBXL20 0.82 12.72 0.57 2.08e-30 Glomerular filtration rate (creatinine); CRC cis rs10028773 0.568 rs6838457 chr4:120267367 A/G cg09307838 chr4:120376055 NA 0.62 9.69 0.47 1.07e-19 Educational attainment; CRC cis rs1712517 0.771 rs61871160 chr10:105144288 C/T cg05636881 chr10:105038444 INA 0.47 8.11 0.41 1.04e-14 Migraine; CRC cis rs6952808 1.000 rs4449693 chr7:1884630 G/C cg21782813 chr7:2030301 MAD1L1 0.45 7.41 0.38 1.07e-12 Bipolar disorder and schizophrenia; CRC cis rs28386778 0.897 rs2156903 chr17:61937179 G/A cg06873352 chr17:61820015 STRADA 0.73 13.56 0.6 1.36e-33 Prudent dietary pattern; CRC cis rs853679 0.517 rs9295759 chr6:28124469 C/T cg25164649 chr6:28176230 NA 0.78 9.66 0.47 1.33e-19 Depression; CRC cis rs7208859 0.673 rs73265633 chr17:29236306 G/T cg01831904 chr17:28903510 LRRC37B2 -0.56 -5.83 -0.31 1.35e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs9322193 0.923 rs9688517 chr6:150061791 T/C cg05861140 chr6:150128134 PCMT1 -0.36 -5.86 -0.31 1.13e-8 Lung cancer; CRC cis rs67311347 1.000 rs977652 chr3:40479169 A/G cg24209194 chr3:40518798 ZNF619 0.45 6.78 0.35 5.61e-11 Renal cell carcinoma; CRC cis rs3736485 0.966 rs2414113 chr15:51903896 C/T cg08986416 chr15:51914746 DMXL2 -0.45 -6.53 -0.34 2.56e-10 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs7589342 0.899 rs879900 chr2:106494347 A/G cg16077055 chr2:106428750 NCK2 0.39 5.61 0.3 4.38e-8 Addiction; CRC cis rs7399018 0.739 rs10747608 chr12:51616582 A/G cg25754956 chr12:51612065 POU6F1 0.75 11.11 0.52 1.49e-24 Cisplatin-induced ototoxicity; CRC cis rs9467773 1.000 rs1535277 chr6:26567802 G/T cg09904177 chr6:26538194 HMGN4 0.86 14.82 0.63 2.06e-38 Intelligence (multi-trait analysis); CRC cis rs8177253 0.965 rs4854760 chr3:133498741 C/T cg08048268 chr3:133502702 NA 0.34 6.46 0.34 3.7e-10 Iron status biomarkers; CRC cis rs1448094 0.511 rs61930037 chr12:86154503 G/A cg06740227 chr12:86229804 RASSF9 0.38 5.7 0.3 2.73e-8 Major depressive disorder; CRC cis rs17067123 0.614 rs72712851 chr4:180066258 A/G cg26610307 chr4:180072759 NA -0.56 -6.74 -0.35 7.28e-11 Response to hepatitis C treatment; CRC cis rs796364 0.951 rs11675980 chr2:201051150 A/G cg12253985 chr2:200820533 C2orf60;C2orf47 -0.53 -5.61 -0.3 4.32e-8 Schizophrenia; CRC cis rs7216064 0.861 rs62084252 chr17:65879578 G/C cg12091567 chr17:66097778 LOC651250 -0.61 -7.5 -0.38 5.93e-13 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CRC cis rs2842992 0.830 rs2025189 chr6:160137518 C/T cg19482086 chr6:160211437 TCP1;MRPL18 0.7 8.85 0.44 5.32e-17 Age-related macular degeneration (geographic atrophy); CRC cis rs875971 0.638 rs3898855 chr7:66036398 G/C cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.43 -6.31 -0.33 9.14e-10 Aortic root size; CRC cis rs6543140 0.964 rs4851010 chr2:103056127 A/T cg04239558 chr2:103089729 SLC9A4 -0.36 -6.05 -0.32 3.88e-9 Blood protein levels; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg00106211 chr6:36514552 STK38 0.46 6.51 0.34 2.77e-10 Response to antipsychotic treatment; CRC cis rs7043114 0.525 rs7045409 chr9:95201540 A/T cg14631576 chr9:95140430 CENPP -0.3 -5.62 -0.3 4.08e-8 Height; CRC cis rs11123610 0.520 rs11682697 chr2:3721127 A/G cg19052272 chr2:3704530 ALLC -0.62 -7.6 -0.39 3.05e-13 Response to inhaled corticosteroid treatment in asthma (change in FEV1); CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg03176143 chr19:4066940 ZBTB7A 0.52 7.3 0.37 2.25e-12 Anxiety disorder; CRC cis rs12410462 1.000 rs16847833 chr1:227626662 G/A cg04117972 chr1:227635322 NA 0.68 7.7 0.39 1.62e-13 Major depressive disorder; CRC cis rs6076065 0.963 rs6048777 chr20:23373302 C/T cg11657817 chr20:23433608 CST11 0.37 5.92 0.31 8.15e-9 Facial morphology (factor 15, philtrum width); CRC cis rs13108904 0.840 rs3915420 chr4:1260337 T/C cg19318889 chr4:1322082 MAEA 0.39 5.64 0.3 3.73e-8 Obesity-related traits; CRC trans rs1005277 0.579 rs1740749 chr10:38521646 A/G cg23533926 chr12:111358616 MYL2 -0.56 -8.67 -0.43 2e-16 Extrinsic epigenetic age acceleration; CRC cis rs477692 0.685 rs534430 chr10:131398734 A/C cg05714579 chr10:131428358 MGMT 0.52 7.16 0.37 5.17e-12 Response to temozolomide; CRC cis rs1552244 0.935 rs7621551 chr3:10114205 C/T cg16606324 chr3:10149918 C3orf24 0.72 9.82 0.48 3.92e-20 Alzheimer's disease; CRC cis rs11792861 0.619 rs2289481 chr9:111712924 G/C cg14432460 chr9:111696404 IKBKAP;C9orf6 0.51 7.35 0.38 1.6e-12 Menarche (age at onset); CRC cis rs2952156 0.920 rs2952152 chr17:37832735 T/C cg20243544 chr17:37824526 PNMT 0.56 9.0 0.44 1.86e-17 Asthma; CRC cis rs950169 0.723 rs17589320 chr15:84919996 C/A cg11189052 chr15:85197271 WDR73 0.64 8.98 0.44 2.11e-17 Schizophrenia; CRC cis rs2739330 0.828 rs5760108 chr22:24252668 G/T cg10819733 chr22:24237672 NA -0.37 -6.29 -0.33 1.02e-9 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs644799 0.544 rs687559 chr11:95598629 C/T cg25622487 chr11:95524042 FAM76B;CEP57 -0.48 -7.06 -0.36 9.82e-12 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg03143033 chr16:75032853 ZNRF1 0.39 6.16 0.32 2.09e-9 Liver disease severity in Alagille syndrome; CRC cis rs763014 0.593 rs28455838 chr16:681966 T/C cg03804128 chr16:635623 NA 0.28 6.49 0.34 3.24e-10 Height; CRC cis rs10504229 0.683 rs56058640 chr8:58128862 C/T cg04204079 chr8:58130323 NA -0.45 -5.78 -0.3 1.71e-8 Developmental language disorder (linguistic errors); CRC cis rs911555 0.755 rs55742283 chr14:103942965 A/G cg12935359 chr14:103987150 CKB 0.56 9.16 0.45 5.85e-18 Intelligence (multi-trait analysis); CRC cis rs7552404 0.924 rs3818855 chr1:76198785 C/T cg03433033 chr1:76189801 ACADM 0.86 13.21 0.59 2.95e-32 Blood metabolite levels;Acylcarnitine levels; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg04213235 chr1:145826932 GPR89A 0.52 7.25 0.37 2.99e-12 Response to antipsychotic treatment; CRC cis rs6700896 0.931 rs4655574 chr1:66135328 T/A cg04111102 chr1:66153794 NA 0.35 6.14 0.32 2.32e-9 C-reactive protein;Mean corpuscular volume;Mean corpuscular hemoglobin; CRC trans rs3780486 0.505 rs7868663 chr9:33141229 A/G cg20290983 chr6:43655470 MRPS18A 0.98 18.08 0.71 3.2e-51 IgG glycosylation; CRC cis rs7659604 0.539 rs11098645 chr4:122729251 G/A cg20573242 chr4:122745356 CCNA2 0.57 8.4 0.42 1.37e-15 Type 2 diabetes; CRC cis rs4964805 1.000 rs34307072 chr12:104196304 G/A cg02344784 chr12:104178138 NT5DC3 0.54 7.99 0.4 2.36e-14 Attention deficit hyperactivity disorder; CRC cis rs1552244 0.554 rs13079240 chr3:10047246 C/T cg08888203 chr3:10149979 C3orf24 0.48 7.28 0.37 2.52e-12 Alzheimer's disease; CRC trans rs9528384 0.750 rs12865693 chr13:62256485 A/C cg08375866 chr1:50799151 NA -0.32 -6.0 -0.31 5.08e-9 Verbal declarative memory; CRC cis rs6582630 0.502 rs11495393 chr12:38341194 T/C cg13010199 chr12:38710504 ALG10B 0.48 6.49 0.34 3.1e-10 Drug-induced liver injury (flucloxacillin); CRC cis rs514406 0.929 rs11206035 chr1:53323571 T/C cg24675658 chr1:53192096 ZYG11B -0.57 -8.48 -0.42 7.77e-16 Monocyte count; CRC cis rs736408 0.609 rs2268025 chr3:52795224 A/T cg18404041 chr3:52824283 ITIH1 -0.44 -8.98 -0.44 2.11e-17 Bipolar disorder; CRC cis rs4481887 0.610 rs28763387 chr1:248559244 T/C cg00666640 chr1:248458726 OR2T12 0.4 7.31 0.37 2e-12 Common traits (Other); CRC cis rs9302065 0.681 rs59108692 chr13:95962424 C/A cg24476569 chr13:95954382 ABCC4 -0.39 -5.81 -0.31 1.44e-8 Blood metabolite levels; CRC cis rs1448094 0.511 rs17279133 chr12:86162353 G/A cg02569458 chr12:86230093 RASSF9 0.47 7.78 0.39 9.77e-14 Major depressive disorder; CRC cis rs6502050 0.777 rs7406162 chr17:80086386 C/T cg19223190 chr17:80058835 NA -0.39 -6.25 -0.33 1.27e-9 Life satisfaction; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg24931592 chr11:105948506 AASDHPPT;KBTBD3 0.46 6.5 0.34 2.93e-10 Response to antipsychotic treatment; CRC cis rs9462027 0.628 rs7739003 chr6:34800329 T/C cg07306190 chr6:34760872 UHRF1BP1 -0.34 -6.08 -0.32 3.4e-9 Systemic lupus erythematosus; CRC cis rs17155006 0.655 rs426812 chr7:107728512 T/C cg05962710 chr7:107745446 LAMB4 -0.38 -6.28 -0.33 1.08e-9 Pneumococcal bacteremia; CRC cis rs5017598 1.000 rs5017598 chr6:169211494 A/G cg05672967 chr6:169256475 NA 0.38 5.77 0.3 1.84e-8 Pediatric bone mineral density (femoral neck);Pediatric bone mineral density (hip); CRC cis rs4665809 0.590 rs34728554 chr2:26481959 C/G cg08067268 chr2:26466485 HADHB;HADHA 0.66 8.38 0.42 1.54e-15 Gut microbiome composition (summer); CRC cis rs6502050 0.805 rs4356529 chr17:80157797 A/G cg22110888 chr17:80059540 CCDC57 -0.37 -5.93 -0.31 7.8e-9 Life satisfaction; CRC cis rs5769765 0.908 rs9627800 chr22:50319351 T/C cg22709217 chr22:50311962 ALG12;CRELD2 -1.08 -16.03 -0.66 3.99e-43 Schizophrenia; CRC cis rs950776 0.518 rs12910289 chr15:78822065 T/G cg06917634 chr15:78832804 PSMA4 0.66 10.42 0.5 3.55e-22 Sudden cardiac arrest; CRC cis rs6912958 0.559 rs451465 chr6:88043372 C/T cg04972856 chr6:88032051 C6orf162;GJB7 -0.32 -6.09 -0.32 3.07e-9 Monocyte percentage of white cells; CRC cis rs9916302 0.706 rs2302073 chr17:37457342 A/G cg07936489 chr17:37558343 FBXL20 0.84 10.61 0.5 8.08e-23 Glomerular filtration rate (creatinine); CRC cis rs4728302 0.869 rs7792546 chr7:133595502 G/T cg03336402 chr7:133662267 EXOC4 -0.43 -6.16 -0.32 2.13e-9 Intelligence;Intelligence (multi-trait analysis); CRC trans rs7824557 0.778 rs6601572 chr8:11093337 C/G cg06636001 chr8:8085503 FLJ10661 -0.42 -6.0 -0.31 5.12e-9 Retinal vascular caliber; CRC cis rs17401966 0.838 rs17034643 chr1:10332102 A/G cg19773385 chr1:10388646 KIF1B 0.66 10.88 0.51 9.19e-24 Hepatocellular carcinoma; CRC cis rs9788333 0.792 rs34479949 chr13:21895574 G/A cg25811766 chr13:21894605 NA 0.69 10.92 0.52 6.62e-24 Thiazide-induced adverse metabolic effects in hypertensive patients; CRC cis rs13191362 1.000 rs36107456 chr6:162997399 T/G cg21926612 chr6:163149169 PACRG;PARK2 0.77 11.26 0.53 4.18e-25 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs17818399 0.547 rs13020299 chr2:46758717 A/G cg26688816 chr2:46740690 ATP6V1E2 -0.49 -6.24 -0.33 1.34e-9 Height; CRC cis rs1008375 1.000 rs2215450 chr4:17675394 T/G cg04450456 chr4:17643702 FAM184B 0.39 6.03 0.32 4.37e-9 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs910316 0.967 rs4903292 chr14:75656245 A/G cg08847533 chr14:75593920 NEK9 0.81 14.02 0.61 2.5e-35 Height; CRC cis rs4713118 0.869 rs9283882 chr6:27715258 A/C cg19041857 chr6:27730383 NA -0.41 -5.96 -0.31 6.46e-9 Parkinson's disease; CRC cis rs4665809 1.000 rs4665820 chr2:26309150 T/C cg26119090 chr2:26468346 HADHA;HADHB -0.61 -7.91 -0.4 3.92e-14 Gut microbiome composition (summer); CRC cis rs9486719 1.000 rs11153058 chr6:97012746 C/T cg06623918 chr6:96969491 KIAA0776 -0.82 -9.53 -0.47 3.58e-19 Migraine;Coronary artery disease; CRC cis rs11971779 0.680 rs1986447 chr7:139082080 G/C cg23387468 chr7:139079360 LUC7L2 0.41 7.04 0.36 1.14e-11 Diisocyanate-induced asthma; CRC cis rs7772486 0.875 rs1412080 chr6:146417304 T/C cg23711669 chr6:146136114 FBXO30 0.6 10.27 0.49 1.18e-21 Lobe attachment (rater-scored or self-reported); CRC cis rs1577917 1.000 rs16876529 chr6:86591202 T/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.51 -6.71 -0.35 8.71e-11 Response to antipsychotic treatment; CRC cis rs8067354 0.645 rs2665400 chr17:57880201 G/A cg13753209 chr17:57696993 CLTC 0.44 5.85 0.31 1.19e-8 Hemoglobin concentration; CRC trans rs1814175 0.676 rs1721999 chr11:49917372 A/G cg15704280 chr7:45808275 SEPT13 -0.95 -16.82 -0.68 3.11e-46 Height; CRC cis rs3733346 0.529 rs6842493 chr4:914638 T/C cg08222618 chr4:941054 TMEM175 0.75 15.05 0.64 2.57e-39 Sjögren's syndrome; CRC cis rs7677751 0.848 rs4635872 chr4:55099041 C/A cg13615338 chr4:55094005 PDGFRA 0.4 5.62 0.3 3.97e-8 Corneal astigmatism; CRC cis rs4692589 0.802 rs2877501 chr4:170955277 G/T cg19918862 chr4:170955249 NA 0.51 7.97 0.4 2.66e-14 Anxiety disorder; CRC cis rs947211 0.898 rs1772153 chr1:205745782 C/T cg14893161 chr1:205819251 PM20D1 -0.41 -5.63 -0.3 3.79e-8 Parkinson's disease; CRC cis rs66573146 0.901 rs7668802 chr4:6986236 T/A cg15105060 chr4:7024189 TBC1D14 -0.74 -5.67 -0.3 3.19e-8 Granulocyte percentage of myeloid white cells; CRC cis rs12745968 0.620 rs4847267 chr1:93155347 A/G cg17283838 chr1:93427260 FAM69A 0.47 6.33 0.33 7.89e-10 Bipolar disorder and schizophrenia; CRC cis rs7811142 1.000 rs2406255 chr7:100053690 T/C cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.15 16.13 0.66 1.55e-43 Platelet count; CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg24689420 chr5:179126339 CANX -0.54 -6.58 -0.34 1.8e-10 Diisocyanate-induced asthma; CRC cis rs7945705 0.902 rs10743093 chr11:8869129 A/G cg21881798 chr11:8931708 C11orf17;ST5 0.64 9.67 0.47 1.27e-19 Hemoglobin concentration; CRC cis rs7927771 0.524 rs10769299 chr11:47865160 G/T cg20307385 chr11:47447363 PSMC3 0.46 6.66 0.34 1.18e-10 Subjective well-being; CRC cis rs9811920 0.809 rs4928235 chr3:99706870 G/A cg07805332 chr3:99536008 MIR548G;C3orf26 0.39 5.91 0.31 8.35e-9 Axial length; CRC cis rs4481887 0.893 rs1339991 chr1:248509363 C/T cg13385794 chr1:248469461 NA 0.34 6.19 0.32 1.75e-9 Common traits (Other); CRC cis rs1552244 0.744 rs6763366 chr3:10033544 T/C cg00166722 chr3:10149974 C3orf24 0.61 8.0 0.4 2.17e-14 Alzheimer's disease; CRC cis rs2952156 0.920 rs11078919 chr17:37835755 T/C cg00129232 chr17:37814104 STARD3 -0.7 -12.25 -0.56 1.1e-28 Asthma; CRC cis rs1448094 0.512 rs7309500 chr12:86249647 C/T cg18827107 chr12:86230957 RASSF9 -0.45 -7.49 -0.38 6.6e-13 Major depressive disorder; CRC cis rs7208859 0.623 rs11656844 chr17:29060597 G/T cg01831904 chr17:28903510 LRRC37B2 -0.61 -6.29 -0.33 1.03e-9 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs8177253 0.829 rs6794945 chr3:133518463 A/G cg01448562 chr3:133502909 NA 0.65 10.82 0.51 1.54e-23 Iron status biomarkers; CRC cis rs6951245 0.572 rs79396168 chr7:1048928 C/T cg20603222 chr7:1096387 C7orf50;GPR146 -0.7 -5.69 -0.3 2.78e-8 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs9303280 0.901 rs2290400 chr17:38066240 A/G cg11212589 chr17:38028394 ZPBP2 0.34 6.01 0.31 4.8e-9 Self-reported allergy; CRC cis rs1799949 1.000 rs4793215 chr17:41318932 G/A cg05368731 chr17:41323189 NBR1 0.65 9.39 0.46 1.02e-18 Menopause (age at onset); CRC cis rs11650494 0.908 rs11650087 chr17:47362923 T/A cg08112188 chr17:47440006 ZNF652 1.2 10.77 0.51 2.33e-23 Prostate cancer; CRC cis rs6120849 0.754 rs8501 chr20:33590584 T/C cg08999081 chr20:33150536 PIGU 0.46 5.88 0.31 9.91e-9 Protein C levels; CRC cis rs2839186 0.814 rs2839167 chr21:47661587 A/G cg12516959 chr21:47718080 NA -0.33 -5.72 -0.3 2.38e-8 Testicular germ cell tumor; CRC cis rs1670533 0.697 rs658846 chr4:1084723 G/C cg27284194 chr4:1044797 NA 0.48 5.84 0.31 1.25e-8 Recombination rate (females); CRC cis rs6500395 0.962 rs9934626 chr16:48602761 G/C cg04672837 chr16:48644449 N4BP1 0.42 5.99 0.31 5.43e-9 Response to tocilizumab in rheumatoid arthritis; CRC cis rs1153858 1.000 rs66714503 chr15:45648038 G/C cg21132104 chr15:45694354 SPATA5L1 0.59 8.71 0.43 1.49e-16 Homoarginine levels; CRC cis rs2404602 0.608 rs17361504 chr15:76601871 A/G cg03037974 chr15:76606532 NA 0.78 15.79 0.66 3.49e-42 Blood metabolite levels; CRC cis rs9584850 0.794 rs17470961 chr13:99135314 A/G cg07423050 chr13:99094983 FARP1 0.46 6.45 0.33 4.07e-10 Neuroticism; CRC cis rs727505 1.000 rs10226033 chr7:124521430 C/A cg23710748 chr7:124431027 NA -0.83 -14.62 -0.63 1.16e-37 Lewy body disease; CRC trans rs4942242 0.663 rs7985489 chr13:44206148 T/C cg26741380 chr15:41871084 TYRO3 0.45 6.2 0.32 1.73e-9 Response to tocilizumab in rheumatoid arthritis; CRC cis rs10876993 0.890 rs1678539 chr12:58060359 A/G cg18357645 chr12:58087776 OS9 0.55 7.53 0.38 4.93e-13 Celiac disease or Rheumatoid arthritis; CRC cis rs7568458 0.660 rs6547623 chr2:85801964 T/A cg02493740 chr2:85810744 VAMP5 -0.49 -7.65 -0.39 2.27e-13 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); CRC cis rs6076065 0.723 rs2424534 chr20:23378866 A/G cg11657817 chr20:23433608 CST11 -0.42 -6.28 -0.33 1.08e-9 Facial morphology (factor 15, philtrum width); CRC cis rs796364 0.906 rs281784 chr2:200749749 T/A cg12253985 chr2:200820533 C2orf60;C2orf47 0.6 6.68 0.35 1.02e-10 Schizophrenia; CRC cis rs172166 0.561 rs149973 chr6:27983613 G/T cg03623178 chr6:28175578 NA 0.64 9.66 0.47 1.3e-19 Cardiac Troponin-T levels; CRC cis rs9611565 0.527 rs73178638 chr22:41942904 T/C cg06481639 chr22:41940642 POLR3H -0.56 -6.33 -0.33 7.81e-10 Vitiligo; CRC cis rs7615952 0.599 rs12486459 chr3:125741465 T/G cg04553112 chr3:125709451 NA -0.51 -5.71 -0.3 2.5e-8 Blood pressure (smoking interaction); CRC cis rs4665809 1.000 rs4665305 chr2:26313524 C/T cg25036284 chr2:26402008 FAM59B -0.44 -5.94 -0.31 7.23e-9 Gut microbiome composition (summer); CRC cis rs1223397 0.938 rs3817737 chr6:13279082 A/G cg20827128 chr6:13274284 PHACTR1 0.54 6.36 0.33 6.6e-10 Blood pressure; CRC cis rs4555082 0.874 rs1008628 chr14:105722726 T/C cg18132624 chr14:105716052 BTBD6;BRF1 -0.46 -7.47 -0.38 7.52e-13 Mean platelet volume;Platelet distribution width; CRC cis rs4819052 0.565 rs35776291 chr21:46706142 T/C cg02159808 chr21:46707872 POFUT2;LOC642852 0.44 6.34 0.33 7.75e-10 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs3733585 0.699 rs6449157 chr4:9960442 G/A cg11266682 chr4:10021025 SLC2A9 -0.48 -9.86 -0.48 2.88e-20 Cleft plate (environmental tobacco smoke interaction); CRC cis rs832540 0.966 rs252923 chr5:56205662 T/G cg12311346 chr5:56204834 C5orf35 -0.48 -7.46 -0.38 7.92e-13 Coronary artery disease; CRC cis rs10782582 0.593 rs17848068 chr1:76190216 G/A cg03433033 chr1:76189801 ACADM -0.45 -6.67 -0.35 1.09e-10 Daytime sleep phenotypes; CRC cis rs6088590 0.561 rs6059932 chr20:33175466 C/T cg08999081 chr20:33150536 PIGU 0.64 12.35 0.56 4.59e-29 Coronary artery disease; CRC cis rs11252926 0.550 rs10904148 chr10:454551 G/T cg18196295 chr10:418757 DIP2C 0.51 8.05 0.41 1.48e-14 Psychosis in Alzheimer's disease; CRC cis rs853679 0.517 rs9366715 chr6:28064633 A/G cg15845792 chr6:28175446 NA 0.99 13.1 0.59 7.48e-32 Depression; CRC cis rs7726839 0.574 rs72705017 chr5:623733 G/A cg16447950 chr5:562315 NA -0.74 -9.76 -0.47 6.14e-20 Obesity-related traits; CRC cis rs2836974 0.563 rs6517522 chr21:40553845 T/C cg11644478 chr21:40555479 PSMG1 0.52 7.81 0.4 7.83e-14 Cognitive function; CRC trans rs7395662 0.500 rs7951327 chr11:48925359 C/T cg00717180 chr2:96193071 NA -0.39 -6.47 -0.34 3.53e-10 HDL cholesterol; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg06538998 chr16:28503160 CLN3 0.4 6.19 0.32 1.84e-9 Liver disease severity in Alagille syndrome; CRC cis rs55871839 0.640 rs4738734 chr8:59814330 A/T cg07426533 chr8:59803705 TOX -0.34 -5.94 -0.31 7.22e-9 Pneumonia; CRC cis rs11190604 1.000 rs2295780 chr10:102305965 A/G cg16342193 chr10:102329863 NA -0.39 -6.32 -0.33 8.56e-10 Palmitoleic acid (16:1n-7) levels; CRC cis rs6499255 1.000 rs73579458 chr16:69804764 G/C cg00738113 chr16:70207722 CLEC18C -0.41 -5.86 -0.31 1.12e-8 IgE levels; CRC cis rs17270561 0.609 rs1165181 chr6:25825390 T/A cg17691542 chr6:26056736 HIST1H1C 0.53 7.61 0.39 2.84e-13 Iron status biomarkers; CRC cis rs6502050 0.723 rs11650635 chr17:80083816 T/C cg02741985 chr17:80059408 CCDC57 -0.44 -7.15 -0.37 5.61e-12 Life satisfaction; CRC cis rs1997103 1.000 rs1997103 chr7:55395390 C/G cg17469321 chr7:55412551 NA 0.74 11.28 0.53 3.63e-25 QRS interval (sulfonylurea treatment interaction); CRC cis rs1816752 0.746 rs9511270 chr13:25018680 C/T cg02811702 chr13:24901961 NA 0.47 6.47 0.34 3.6e-10 Obesity-related traits; CRC cis rs7412746 0.611 rs7532045 chr1:150821847 G/A cg17724175 chr1:150552817 MCL1 0.45 6.68 0.35 1.03e-10 Melanoma; CRC cis rs13108904 0.870 rs12499546 chr4:1255194 C/T cg21620606 chr4:1342894 KIAA1530 0.4 6.94 0.36 2.06e-11 Obesity-related traits; CRC cis rs4713118 0.869 rs9366700 chr6:27696951 C/T cg15845792 chr6:28175446 NA 0.65 9.11 0.45 7.98e-18 Parkinson's disease; CRC cis rs4253772 0.550 rs6007818 chr22:46703776 C/T cg03482458 chr22:46692211 CN5H6.4;GTSE1 0.5 6.23 0.32 1.43e-9 LDL cholesterol;Cholesterol, total; CRC cis rs2239547 0.603 rs34230854 chr3:53078590 C/A cg10802521 chr3:52805072 NEK4 -0.47 -6.15 -0.32 2.19e-9 Schizophrenia; CRC cis rs1448094 0.511 rs61930590 chr12:86159959 T/A cg18827107 chr12:86230957 RASSF9 -0.38 -5.84 -0.31 1.26e-8 Major depressive disorder; CRC cis rs3741151 0.686 rs12291233 chr11:73272946 T/G cg17517138 chr11:73019481 ARHGEF17 0.55 5.62 0.3 4.03e-8 GIP levels in response to oral glucose tolerance test (120 minutes); CRC cis rs172166 0.516 rs2791333 chr6:28111114 A/G cg21251018 chr6:28226885 NKAPL 0.57 10.06 0.49 6.1e-21 Cardiac Troponin-T levels; CRC cis rs58688157 0.705 rs12419618 chr11:611531 G/A cg02461776 chr11:598696 PHRF1 0.46 5.82 0.31 1.37e-8 Systemic lupus erythematosus; CRC cis rs7122539 0.646 rs543191 chr11:66583779 T/G cg24851651 chr11:66362959 CCS 0.52 9.95 0.48 1.42e-20 HIV-1 susceptibility; CRC cis rs933688 1.000 rs7720132 chr5:90745105 T/C cg26981201 chr5:90679533 LOC100129716;ARRDC3 0.98 15.01 0.64 3.59e-39 Smoking behavior; CRC cis rs1046896 0.553 rs3744160 chr17:80828303 G/A cg16060761 chr17:80687452 NA -0.46 -6.04 -0.32 4.28e-9 Glycated hemoglobin levels; CRC cis rs12476592 0.602 rs262530 chr2:63904274 A/T cg10828910 chr2:63850056 LOC388955 0.51 6.33 0.33 7.99e-10 Childhood ear infection; CRC cis rs7824557 0.505 rs2736313 chr8:11086942 C/T cg20542592 chr8:11973495 FAM66D -0.34 -5.96 -0.31 6.63e-9 Retinal vascular caliber; CRC cis rs4665809 0.618 rs7579199 chr2:26266496 G/A cg04944784 chr2:26401820 FAM59B -0.6 -7.68 -0.39 1.81e-13 Gut microbiome composition (summer); CRC cis rs6831352 0.918 rs17218162 chr4:100056060 G/A cg12011299 chr4:100065546 ADH4 -0.49 -9.25 -0.45 2.96e-18 Alcohol dependence; CRC cis rs1348850 0.872 rs2084233 chr2:178331206 G/A cg02961200 chr2:178257176 LOC100130691;AGPS 0.64 9.37 0.46 1.19e-18 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs11191270 0.554 rs11191265 chr10:104102118 G/A cg15320455 chr10:103880129 LDB1 0.75 6.95 0.36 1.93e-11 Intelligence (multi-trait analysis); CRC cis rs11212617 0.935 rs227070 chr11:108211412 T/G cg01991180 chr11:108092276 ATM;NPAT 0.41 5.91 0.31 8.7e-9 Response to metformin in type 2 diabetes (glycemic); CRC cis rs1728785 0.901 rs2862781 chr16:68639234 A/T cg02972257 chr16:68554789 NA -0.54 -6.73 -0.35 7.68e-11 Ulcerative colitis; CRC cis rs4363385 0.765 rs11205165 chr1:152986928 G/T cg25856811 chr1:152973957 SPRR3 -0.26 -7.22 -0.37 3.65e-12 Inflammatory skin disease; CRC cis rs4713118 0.868 rs9468220 chr6:27732976 A/G cg12273811 chr6:28175739 NA -0.52 -5.83 -0.31 1.32e-8 Parkinson's disease; CRC cis rs4908768 0.501 rs12061328 chr1:8531963 C/T cg20416874 chr1:8611966 RERE -0.43 -6.13 -0.32 2.55e-9 Neuroticism (multi-trait analysis);Subjective well-being (multi-trait analysis); CRC cis rs317689 0.918 rs610192 chr12:69739941 T/C cg14784868 chr12:69753453 YEATS4 0.59 7.29 0.37 2.37e-12 Response to diuretic therapy; CRC cis rs763014 0.932 rs34498660 chr16:666149 A/G cg00908189 chr16:619842 PIGQ 0.67 11.11 0.52 1.42e-24 Height; CRC trans rs11098499 0.863 rs3775847 chr4:120447642 A/C cg25214090 chr10:38739885 LOC399744 0.65 10.1 0.49 4.61e-21 Corneal astigmatism; CRC cis rs4888262 0.526 rs8062959 chr16:74627628 T/C cg01733217 chr16:74700730 RFWD3 0.79 11.97 0.55 1.22e-27 Testicular germ cell tumor; CRC cis rs7072216 0.763 rs3814142 chr10:100171104 C/G cg26618903 chr10:100175079 PYROXD2 -0.55 -8.99 -0.44 2.03e-17 Metabolite levels; CRC cis rs12476592 0.602 rs262487 chr2:63880517 G/T cg10828910 chr2:63850056 LOC388955 -0.47 -5.95 -0.31 6.74e-9 Childhood ear infection; CRC cis rs9325144 0.560 rs11182952 chr12:38636278 C/A cg26384229 chr12:38710491 ALG10B -0.55 -8.18 -0.41 6.32e-15 Morning vs. evening chronotype; CRC cis rs875971 0.830 rs778711 chr7:65851657 G/A cg18876405 chr7:65276391 NA 0.54 8.69 0.43 1.77e-16 Aortic root size; CRC cis rs7208859 0.573 rs7222803 chr17:29119897 A/G cg01831904 chr17:28903510 LRRC37B2 -0.62 -6.41 -0.33 4.96e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs2576037 0.623 rs2576042 chr18:44577461 T/C cg07416455 chr18:44543612 TCEB3CL;KATNAL2 0.63 9.49 0.46 4.91e-19 Personality dimensions; CRC cis rs2180341 0.814 rs9321085 chr6:127735361 T/C cg24812749 chr6:127587940 RNF146 0.67 9.02 0.45 1.59e-17 Breast cancer; CRC trans rs2303319 0.504 rs62189041 chr2:162599506 T/C cg10272801 chr16:14013773 ERCC4 -0.68 -6.07 -0.32 3.49e-9 Cognitive function; CRC cis rs2692947 0.770 rs72823920 chr2:96430876 G/A cg23100626 chr2:96804247 ASTL 0.27 7.01 0.36 1.34e-11 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; CRC cis rs796364 0.806 rs11691873 chr2:200966337 A/G cg25936922 chr2:200820526 C2orf60;C2orf47 -0.66 -6.17 -0.32 2.02e-9 Schizophrenia; CRC cis rs1799949 0.501 rs2343819 chr17:41409653 T/G cg01879757 chr17:41196368 BRCA1 -0.44 -6.68 -0.35 1.04e-10 Menopause (age at onset); CRC cis rs7927592 0.913 rs67005337 chr11:68307758 A/C cg16797656 chr11:68205561 LRP5 0.36 5.75 0.3 2.08e-8 Total body bone mineral density; CRC cis rs344364 0.511 rs12596510 chr16:1949480 G/A cg00046913 chr16:1877150 HAGH;FAHD1 -0.58 -6.06 -0.32 3.66e-9 Glomerular filtration rate in chronic kidney disease; CRC cis rs11203032 0.831 rs10887925 chr10:90938902 G/T cg16672925 chr10:90967113 CH25H 0.45 5.7 0.3 2.64e-8 Heart failure; CRC cis rs7635838 0.892 rs4684775 chr3:11436413 A/G cg00170343 chr3:11313890 ATG7 0.41 6.28 0.33 1.08e-9 HDL cholesterol; CRC cis rs4713118 0.824 rs13211701 chr6:27750079 T/C cg21251018 chr6:28226885 NKAPL 0.42 6.06 0.32 3.81e-9 Parkinson's disease; CRC cis rs7927771 0.965 rs11039416 chr11:47846711 G/A cg20307385 chr11:47447363 PSMC3 -0.49 -6.56 -0.34 2.04e-10 Subjective well-being; CRC cis rs11628318 0.853 rs6575925 chr14:103034507 C/T cg23071808 chr14:103021642 NA -0.67 -8.67 -0.43 2.07e-16 Platelet count; CRC cis rs2204008 0.583 rs12820907 chr12:37990931 T/C cg26384229 chr12:38710491 ALG10B 0.67 9.43 0.46 7.83e-19 Bladder cancer; CRC cis rs1691799 0.899 rs903590 chr12:66745777 C/G cg16791601 chr12:66731901 HELB -0.69 -11.91 -0.55 1.95e-27 White blood cell count (basophil); CRC cis rs8014204 0.550 rs7152906 chr14:75125540 T/C cg03030879 chr14:75389066 RPS6KL1 -0.43 -6.76 -0.35 6.25e-11 Caffeine consumption; CRC trans rs11026407 0.967 rs7127246 chr11:22060228 C/G cg06151567 chr1:17765735 RCC2 -0.61 -6.07 -0.32 3.46e-9 Plasma thyroid-stimulating hormone levels; CRC cis rs1448094 0.510 rs11117016 chr12:86141602 T/C cg18827107 chr12:86230957 RASSF9 0.39 5.96 0.31 6.6e-9 Major depressive disorder; CRC cis rs9393692 0.599 rs9358920 chr6:26292029 C/T cg13736514 chr6:26305472 NA -0.46 -7.55 -0.38 4.45e-13 Educational attainment; CRC trans rs2055729 0.677 rs6601393 chr8:9741035 G/A cg08975724 chr8:8085496 FLJ10661 -0.46 -6.02 -0.31 4.63e-9 Multiple myeloma (hyperdiploidy); CRC cis rs6714710 0.580 rs35564270 chr2:98602165 A/G cg26665480 chr2:98280029 ACTR1B 0.53 7.34 0.37 1.72e-12 Posterior cortical atrophy and Alzheimer's disease; CRC cis rs10743315 0.599 rs11044451 chr12:19365798 C/T cg02471346 chr12:19282374 PLEKHA5 -0.75 -8.31 -0.42 2.55e-15 Gut microbiota (bacterial taxa); CRC cis rs7493 1.000 rs12026 chr7:95041016 G/C cg19678392 chr7:94953810 PON1 -0.56 -7.07 -0.36 9.28e-12 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs116095464 0.558 rs10056628 chr5:279512 G/A cg22857025 chr5:266934 NA -1.16 -11.98 -0.55 1.13e-27 Breast cancer; CRC cis rs929354 0.772 rs3802123 chr7:156970641 G/A cg05182265 chr7:156933206 UBE3C -0.73 -13.06 -0.58 1.05e-31 Body mass index; CRC cis rs79839061 0.610 rs11731387 chr4:851357 C/T cg07828340 chr4:882639 GAK 1.1 10.82 0.51 1.56e-23 Intelligence (multi-trait analysis); CRC cis rs11212617 0.901 rs2083707 chr11:108066130 A/T cg01991180 chr11:108092276 ATM;NPAT 0.39 5.76 0.3 1.94e-8 Response to metformin in type 2 diabetes (glycemic); CRC cis rs11741688 0.557 rs10043579 chr5:178330174 C/T cg20935368 chr5:178288625 ZNF354B 0.43 7.01 0.36 1.32e-11 Sleep duration; CRC cis rs977987 0.586 rs12920883 chr16:75432681 T/C cg03315344 chr16:75512273 CHST6 0.54 9.04 0.45 1.36e-17 Dupuytren's disease; CRC trans rs6601327 0.641 rs7461939 chr8:9571621 C/T cg06636001 chr8:8085503 FLJ10661 -0.52 -7.56 -0.38 4.1e-13 Multiple myeloma (hyperdiploidy); CRC cis rs2991971 0.782 rs10789463 chr1:45927848 C/A cg15605315 chr1:45957053 TESK2 -0.36 -5.84 -0.31 1.28e-8 High light scatter reticulocyte count; CRC cis rs950776 0.518 rs12594391 chr15:78816240 A/G cg23880581 chr15:78912387 CHRNA3 0.33 5.62 0.3 4e-8 Sudden cardiac arrest; CRC cis rs45509595 0.659 rs390764 chr6:27782535 C/T cg15845792 chr6:28175446 NA 0.72 6.15 0.32 2.24e-9 Breast cancer; CRC cis rs8031584 0.958 rs1043742 chr15:31232581 A/C cg08704250 chr15:31115839 NA -0.41 -7.71 -0.39 1.47e-13 Huntington's disease progression; CRC cis rs11864453 0.514 rs2269918 chr16:72134831 C/A cg23815491 chr16:72088622 HP 0.51 7.78 0.39 9.45e-14 Fibrinogen levels; CRC cis rs7677751 0.806 rs73252942 chr4:55104604 T/C cg00691999 chr4:55094011 PDGFRA 0.4 5.93 0.31 7.46e-9 Corneal astigmatism; CRC trans rs11098499 0.863 rs1383533 chr4:120434576 G/A cg25214090 chr10:38739885 LOC399744 0.62 9.71 0.47 9.26e-20 Corneal astigmatism; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg25179170 chr1:93427589 FAM69A 0.41 6.13 0.32 2.55e-9 Intelligence (multi-trait analysis); CRC cis rs12024301 0.557 rs10157799 chr1:183655121 C/T cg11505048 chr1:183622726 RGL1;APOBEC4 0.67 6.13 0.32 2.5e-9 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs7267979 0.816 rs390123 chr20:25480105 C/G cg24626310 chr20:25276739 ABHD12;PYGB 0.33 5.84 0.31 1.26e-8 Liver enzyme levels (alkaline phosphatase); CRC cis rs9488822 0.676 rs4354188 chr6:116327936 T/C cg15226275 chr6:116381976 FRK 0.3 8.5 0.42 6.55e-16 Cholesterol, total;LDL cholesterol; CRC cis rs8177253 0.965 rs8177245 chr3:133479230 A/G cg08048268 chr3:133502702 NA -0.37 -6.89 -0.36 2.86e-11 Iron status biomarkers; CRC cis rs6089584 0.853 rs1746280 chr20:60577821 C/G cg13770153 chr20:60521292 NA -0.65 -9.93 -0.48 1.64e-20 Body mass index; CRC cis rs995000 0.899 rs1781221 chr1:63006842 A/C cg19896129 chr1:63156450 NA -0.44 -6.88 -0.35 3.04e-11 Triglyceride levels; CRC cis rs972578 1.000 rs714003 chr22:43369766 T/C cg01576275 chr22:43409880 NA -0.45 -7.28 -0.37 2.47e-12 Mean platelet volume; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg16043990 chr14:104314434 PPP1R13B 0.46 6.38 0.33 5.95e-10 Anxiety disorder; CRC cis rs977987 0.806 rs8051407 chr16:75448659 A/G cg03315344 chr16:75512273 CHST6 0.54 9.08 0.45 1.04e-17 Dupuytren's disease; CRC cis rs13108904 0.935 rs1732102 chr4:1277924 T/C cg20092199 chr4:1342459 KIAA1530 -0.37 -6.68 -0.35 9.98e-11 Obesity-related traits; CRC cis rs6694672 0.717 rs12039586 chr1:196997452 C/G cg13682187 chr1:196946512 CFHR5 0.48 7.58 0.39 3.64e-13 Asthma; CRC cis rs11971779 0.648 rs6467849 chr7:139080512 C/G cg23387468 chr7:139079360 LUC7L2 0.41 7.04 0.36 1.14e-11 Diisocyanate-induced asthma; CRC cis rs10229583 0.527 rs10239440 chr7:127406049 T/C cg01233922 chr7:127693937 SND1 -0.55 -8.13 -0.41 8.83e-15 Type 2 diabetes; CRC cis rs868036 1.000 rs4776377 chr15:68103387 T/C cg05925327 chr15:68127851 NA -0.3 -5.87 -0.31 1.04e-8 Restless legs syndrome; CRC cis rs875971 0.638 rs3898855 chr7:66036398 G/C cg11764359 chr7:65958608 NA -0.55 -8.63 -0.43 2.66e-16 Aortic root size; CRC cis rs9487051 0.676 rs9386788 chr6:109600523 C/T cg21918786 chr6:109611834 NA 0.39 6.94 0.36 2.07e-11 Reticulocyte fraction of red cells; CRC cis rs7945705 0.791 rs12421789 chr11:8813956 G/A cg12365402 chr11:9010492 NRIP3 -0.37 -6.37 -0.33 6.28e-10 Hemoglobin concentration; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg08063013 chr11:63742144 COX8A 0.42 5.98 0.31 5.67e-9 Intelligence (multi-trait analysis); CRC cis rs611744 0.647 rs7015240 chr8:109262204 G/A cg18478394 chr8:109455254 TTC35 0.37 5.73 0.3 2.22e-8 Dupuytren's disease; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg11256290 chr10:32734912 CCDC7 0.38 6.24 0.33 1.32e-9 Liver disease severity in Alagille syndrome; CRC cis rs9443645 0.901 rs10943605 chr6:79655477 G/A cg11833968 chr6:79620685 NA -0.37 -6.4 -0.33 5.44e-10 Intelligence (multi-trait analysis); CRC cis rs25422 0.938 rs9489443 chr6:118886163 T/A cg24463073 chr6:118973353 C6orf204 0.51 6.85 0.35 3.7e-11 Renal cell carcinoma; CRC cis rs863345 0.565 rs10908671 chr1:158502160 G/A cg12129480 chr1:158549410 OR10X1 -0.3 -6.27 -0.33 1.12e-9 Pneumococcal bacteremia; CRC cis rs561341 1.000 rs8069199 chr17:30281845 A/G cg12193833 chr17:30244370 NA -0.62 -7.94 -0.4 3.33e-14 Hip circumference adjusted for BMI; CRC cis rs10927875 0.541 rs1763596 chr1:16343835 C/T cg22431228 chr1:16359049 CLCNKA -0.38 -6.9 -0.36 2.63e-11 Dilated cardiomyopathy; CRC cis rs7811142 0.943 rs28660238 chr7:100023308 C/T cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.02 14.67 0.63 7.4e-38 Platelet count; CRC cis rs2072510 1.000 rs2540492 chr12:96417659 C/T cg22491680 chr12:96389547 HAL -0.38 -5.95 -0.31 6.7e-9 Metabolite levels (small molecules and protein measures); CRC cis rs9911578 1.000 rs12940681 chr17:56933622 T/C cg05425664 chr17:57184151 TRIM37 -0.49 -7.68 -0.39 1.85e-13 Intelligence (multi-trait analysis); CRC cis rs7542091 1.000 rs7542091 chr1:210031948 G/C cg05527609 chr1:210001259 C1orf107 -0.5 -6.86 -0.35 3.53e-11 Monobrow; CRC cis rs59918340 0.738 rs3739235 chr8:142229145 A/G cg23750338 chr8:142222470 SLC45A4 0.61 11.25 0.53 4.79e-25 Immature fraction of reticulocytes; CRC cis rs2019137 0.539 rs6755040 chr2:113981137 T/C cg09704166 chr2:114031854 PAX8;LOC440839 -0.35 -6.46 -0.34 3.8e-10 Lymphocyte counts; CRC cis rs7707921 0.767 rs862245 chr5:81585737 A/C cg07807695 chr5:81608485 ATP6AP1L 0.46 7.3 0.37 2.14e-12 Breast cancer; CRC cis rs9910055 0.530 rs2269906 chr17:42294337 G/T cg13607699 chr17:42295918 UBTF -0.81 -14.46 -0.62 5.09e-37 Total body bone mineral density; CRC cis rs17270561 0.609 rs4464787 chr6:25733558 G/C cg16482183 chr6:26056742 HIST1H1C 0.83 10.66 0.51 5.39e-23 Iron status biomarkers; CRC cis rs7772486 0.774 rs2247571 chr6:146219533 T/A cg23711669 chr6:146136114 FBXO30 0.63 10.79 0.51 1.87e-23 Lobe attachment (rater-scored or self-reported); CRC cis rs8170 1.000 rs34084277 chr19:17387176 A/G cg04749549 chr19:17459798 NA -0.42 -5.94 -0.31 7.07e-9 Breast cancer (estrogen-receptor negative);Breast Cancer in BRCA1 mutation carriers;Ovarian cancer;Breast cancer;Epithelial ovarian cancer; CRC cis rs2952156 0.920 rs1565920 chr17:37831613 G/A cg07936489 chr17:37558343 FBXL20 -0.42 -5.97 -0.31 6.24e-9 Asthma; CRC cis rs2032447 0.736 rs115810 chr6:25975883 G/C cg12310025 chr6:25882481 NA -0.59 -8.15 -0.41 7.57e-15 Intelligence (multi-trait analysis); CRC cis rs9916302 0.629 rs9972882 chr17:37807698 A/C cg20243544 chr17:37824526 PNMT 0.5 7.53 0.38 4.86e-13 Glomerular filtration rate (creatinine); CRC cis rs10193935 0.901 rs10201586 chr2:42622594 C/G cg27598129 chr2:42591480 NA -0.65 -7.42 -0.38 9.79e-13 Colonoscopy-negative controls vs population controls; CRC trans rs6076960 0.684 rs3844461 chr20:6253115 G/A cg24759859 chr6:86352639 SYNCRIP 0.47 6.4 0.33 5.23e-10 Smooth-surface caries; CRC cis rs2842992 0.673 rs6930904 chr6:160217433 T/A cg19482086 chr6:160211437 TCP1;MRPL18 0.73 9.6 0.47 2.07e-19 Age-related macular degeneration (geographic atrophy); CRC trans rs9840812 0.953 rs4678322 chr3:135812523 G/T cg17080335 chr12:131030206 NA 0.41 6.2 0.32 1.65e-9 Fibrinogen levels; CRC cis rs4713118 0.869 rs9461400 chr6:27700559 A/G cg12273811 chr6:28175739 NA 0.53 7.64 0.39 2.4e-13 Parkinson's disease; CRC trans rs8002861 0.905 rs11617551 chr13:44443977 T/C cg17145862 chr1:211918768 LPGAT1 -0.68 -12.47 -0.57 1.73e-29 Leprosy; CRC cis rs9487051 0.837 rs6568561 chr6:109592909 A/G cg01475377 chr6:109611718 NA -0.48 -8.99 -0.44 2.02e-17 Reticulocyte fraction of red cells; CRC cis rs782590 0.935 rs782652 chr2:55862775 C/A cg18811423 chr2:55921094 PNPT1 0.81 14.79 0.63 2.55e-38 Metabolic syndrome; CRC cis rs35146811 0.844 rs10281368 chr7:99655897 A/G cg13334819 chr7:99746414 C7orf59 -0.56 -7.68 -0.39 1.82e-13 Coronary artery disease; CRC cis rs875971 0.862 rs7782704 chr7:65805366 G/A cg18252515 chr7:66147081 NA 0.4 5.79 0.3 1.63e-8 Aortic root size; CRC cis rs2842992 0.830 rs2758313 chr6:160154099 C/G cg11366901 chr6:160182831 ACAT2 1.0 14.76 0.63 3.57e-38 Age-related macular degeneration (geographic atrophy); CRC cis rs79349575 0.811 rs1057897 chr17:47005509 T/G cg22482690 chr17:47019901 SNF8 0.47 7.81 0.4 7.67e-14 Type 2 diabetes; CRC cis rs4713118 0.868 rs9468220 chr6:27732976 A/G cg15845792 chr6:28175446 NA -0.65 -7.02 -0.36 1.25e-11 Parkinson's disease; CRC cis rs2227564 0.574 rs3849969 chr10:75525999 C/T cg00564723 chr10:75632066 CAMK2G 0.29 6.96 0.36 1.84e-11 Crohn's disease;Inflammatory bowel disease; CRC cis rs713477 1.000 rs12888361 chr14:55906187 A/G cg13175173 chr14:55914753 NA -0.52 -9.84 -0.48 3.33e-20 Pediatric bone mineral content (femoral neck); CRC cis rs55788414 0.932 rs729265 chr16:81183600 G/A cg06400318 chr16:81190750 PKD1L2 -0.59 -6.76 -0.35 6.2e-11 Left ventricular obstructive tract defect (maternal effect); CRC cis rs10504229 0.906 rs17805439 chr8:58172400 T/C cg22535103 chr8:58192502 C8orf71 -0.82 -12.27 -0.56 9.63e-29 Developmental language disorder (linguistic errors); CRC cis rs12586317 0.513 rs17102962 chr14:35478782 A/T cg05294307 chr14:35346193 BAZ1A -0.71 -7.76 -0.39 1.11e-13 Psoriasis; CRC cis rs4665809 0.590 rs9309474 chr2:26448830 T/A cg26119090 chr2:26468346 HADHA;HADHB -1.06 -15.5 -0.65 4.69e-41 Gut microbiome composition (summer); CRC cis rs12368653 0.525 rs1564374 chr12:58010163 C/T cg00677455 chr12:58241039 CTDSP2 -0.41 -5.91 -0.31 8.43e-9 Multiple sclerosis; CRC cis rs853679 0.599 rs149949 chr6:28011516 T/C cg15845792 chr6:28175446 NA 0.71 6.75 0.35 6.81e-11 Depression; CRC cis rs1209950 0.536 rs468057 chr21:40217306 T/G cg02119577 chr21:40195074 ETS2 -0.36 -5.77 -0.3 1.79e-8 Non-small cell lung cancer (survival); CRC cis rs1008375 1.000 rs10009541 chr4:17682218 C/T cg04450456 chr4:17643702 FAM184B -0.38 -6.05 -0.32 3.86e-9 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs2836974 0.584 rs7276774 chr21:40628725 T/G cg11890956 chr21:40555474 PSMG1 -0.92 -16.24 -0.67 5.77e-44 Cognitive function; CRC cis rs6691722 0.503 rs4140519 chr1:24708304 C/T cg02336364 chr1:24764700 NIPAL3 0.38 6.31 0.33 9.18e-10 Response to interferon beta in multiple sclerosis; CRC cis rs12681288 0.823 rs12681230 chr8:994422 G/A cg15309053 chr8:964076 NA 0.4 7.35 0.38 1.54e-12 Schizophrenia; CRC trans rs747782 0.528 rs7937670 chr11:48313216 C/T cg15704280 chr7:45808275 SEPT13 0.68 6.6 0.34 1.61e-10 Intraocular pressure; CRC cis rs9372498 0.536 rs724868 chr6:118795152 C/T cg24463073 chr6:118973353 C6orf204 0.55 7.11 0.36 7.38e-12 Diastolic blood pressure; CRC cis rs2404602 0.692 rs2304920 chr15:76993867 T/C cg22467129 chr15:76604101 ETFA -0.41 -6.87 -0.35 3.16e-11 Blood metabolite levels; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg24043236 chr3:98312515 CPOX 0.39 6.32 0.33 8.38e-10 Liver disease severity in Alagille syndrome; CRC cis rs9858542 0.953 rs9837341 chr3:49664767 A/G cg07274523 chr3:49395745 GPX1 0.47 6.07 0.32 3.48e-9 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs12477438 0.798 rs4850894 chr2:99629396 A/T cg14399236 chr2:99771627 LIPT1;TSGA10 -0.74 -10.4 -0.5 4.36e-22 Chronic sinus infection; CRC cis rs6952808 0.573 rs12668848 chr7:2020995 G/A cg00106254 chr7:1943704 MAD1L1 -0.43 -6.56 -0.34 2.15e-10 Bipolar disorder and schizophrenia; CRC cis rs96067 0.711 rs11263861 chr1:36628033 G/A cg25304816 chr1:36627734 MAP7D1 0.61 10.06 0.48 6.41e-21 Corneal structure; CRC cis rs6951245 0.580 rs77101766 chr7:1122438 A/G cg24642844 chr7:1081250 C7orf50 -0.5 -6.38 -0.33 6.11e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs7394190 0.748 rs11000728 chr10:75404300 C/G cg07699608 chr10:75541558 CHCHD1 0.61 6.21 0.32 1.63e-9 Incident atrial fibrillation; CRC cis rs7707921 0.767 rs6880209 chr5:81574182 C/T cg07807695 chr5:81608485 ATP6AP1L 0.5 7.79 0.39 8.55e-14 Breast cancer; CRC cis rs7647973 1.000 rs7644148 chr3:49545241 G/A cg07636037 chr3:49044803 WDR6 -0.65 -7.65 -0.39 2.18e-13 Menarche (age at onset); CRC cis rs12476592 0.543 rs262470 chr2:63830559 C/T cg10828910 chr2:63850056 LOC388955 0.5 6.13 0.32 2.54e-9 Childhood ear infection; CRC cis rs6952808 0.771 rs10275045 chr7:1920826 C/T cg14004847 chr7:1930337 MAD1L1 -0.49 -7.17 -0.37 4.84e-12 Bipolar disorder and schizophrenia; CRC cis rs6933660 0.745 rs3800272 chr6:151744283 A/G cg14262678 chr6:151773367 RMND1;C6orf211 -0.5 -8.1 -0.41 1.05e-14 Menarche (age at onset); CRC trans rs9467711 0.606 rs13212985 chr6:26609989 G/C cg06606381 chr12:133084897 FBRSL1 -1.07 -7.41 -0.38 1.09e-12 Autism spectrum disorder or schizophrenia; CRC cis rs12928939 0.911 rs8051878 chr16:71818431 C/G cg03805757 chr16:71968109 PKD1L3 -0.47 -6.06 -0.32 3.75e-9 Post bronchodilator FEV1; CRC cis rs11792861 1.000 rs11792861 chr9:111809295 A/C cg05043794 chr9:111880884 C9orf5 -0.34 -6.31 -0.33 9.12e-10 Menarche (age at onset); CRC trans rs1814175 0.817 rs7927373 chr11:49957640 A/C cg21153622 chr11:89784906 NA -0.37 -6.03 -0.32 4.33e-9 Height; CRC trans rs1814175 0.500 rs1825677 chr11:49233099 T/G cg21153622 chr11:89784906 NA -0.5 -8.07 -0.41 1.34e-14 Height; CRC cis rs172166 0.611 rs203883 chr6:28078356 A/G cg02683197 chr6:28174875 NA 0.68 9.38 0.46 1.09e-18 Cardiac Troponin-T levels; CRC cis rs6545883 0.895 rs796597 chr2:61681060 A/G cg15711740 chr2:61764176 XPO1 -0.44 -5.81 -0.31 1.45e-8 Tuberculosis; CRC cis rs2625529 0.652 rs28650442 chr15:72155445 A/T cg16672083 chr15:72433130 SENP8 -0.46 -6.86 -0.35 3.42e-11 Red blood cell count; CRC cis rs7772486 0.743 rs9376955 chr6:145949404 T/A cg13319975 chr6:146136371 FBXO30 -0.39 -5.82 -0.31 1.43e-8 Lobe attachment (rater-scored or self-reported); CRC cis rs1153858 0.887 rs7164139 chr15:45670851 G/A cg10760299 chr15:45669010 GATM 0.49 7.65 0.39 2.19e-13 Homoarginine levels; CRC trans rs9585327 0.584 rs4772260 chr13:100645723 A/G cg16975973 chr12:77459865 E2F7 0.37 6.02 0.31 4.74e-9 Myopia; CRC cis rs3806843 0.868 rs2531345 chr5:140126781 T/G cg19875535 chr5:140030758 IK -0.53 -8.41 -0.42 1.22e-15 Depressive symptoms (multi-trait analysis); CRC trans rs1045529 0.524 rs34251783 chr8:8891376 T/C cg16141378 chr3:129829833 LOC729375 0.4 6.13 0.32 2.57e-9 Myopia;Myopia (pathological); CRC cis rs9517320 1.000 rs9513430 chr13:99127252 C/G cg20487152 chr13:99095054 FARP1 0.36 5.9 0.31 8.88e-9 Longevity; CRC cis rs9902453 0.967 rs34323226 chr17:28517454 C/T cg26525008 chr17:28256777 EFCAB5;SSH2 0.59 9.12 0.45 7.64e-18 Coffee consumption (cups per day); CRC cis rs875971 0.767 rs61348003 chr7:66005934 C/T cg11764359 chr7:65958608 NA 0.58 8.68 0.43 1.85e-16 Aortic root size; CRC cis rs11997175 0.574 rs4364597 chr8:33653729 G/C cg04338863 chr8:33670619 NA 0.39 6.76 0.35 6.31e-11 Body mass index; CRC cis rs9322193 0.962 rs9393175 chr6:149998723 A/G cg07701084 chr6:150067640 NUP43 0.57 7.94 0.4 3.15e-14 Lung cancer; CRC cis rs939658 0.805 rs11631590 chr15:79446199 C/T cg17916960 chr15:79447300 NA -0.45 -7.51 -0.38 5.46e-13 Refractive error; CRC cis rs6500602 0.627 rs2270363 chr16:4526292 A/G cg06139259 chr16:4526053 HMOX2;NMRAL1 0.53 6.88 0.35 2.99e-11 Schizophrenia; CRC cis rs7772486 0.846 rs1331636 chr6:146338826 T/C cg23711669 chr6:146136114 FBXO30 0.67 11.53 0.54 4.5e-26 Lobe attachment (rater-scored or self-reported); CRC cis rs12612619 0.704 rs2119026 chr2:27310393 A/G cg00617064 chr2:27272375 NA 0.35 5.79 0.3 1.62e-8 Venous thromboembolism adjusted for sickle cell variant rs77121243-T; CRC cis rs722599 0.748 rs17093914 chr14:75363641 A/G cg08847533 chr14:75593920 NEK9 0.44 5.91 0.31 8.39e-9 IgG glycosylation; CRC cis rs1957429 0.808 rs11628910 chr14:65332392 A/G cg23373153 chr14:65346875 NA 0.66 6.74 0.35 7.01e-11 Pediatric areal bone mineral density (radius); CRC cis rs6502050 0.712 rs8077079 chr17:80059011 C/T cg13939156 chr17:80058883 NA 0.36 5.69 0.3 2.83e-8 Life satisfaction; CRC cis rs6951245 0.832 rs79808627 chr7:1092519 C/G cg03188948 chr7:1209495 NA 0.56 6.49 0.34 3.19e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs4862750 0.914 rs6814259 chr4:187872337 T/C cg06074448 chr4:187884817 NA -0.59 -10.72 -0.51 3.34e-23 Lobe attachment (rater-scored or self-reported); CRC cis rs6963495 0.745 rs73190179 chr7:105162812 C/A cg02135003 chr7:105160482 PUS7 -0.9 -12.2 -0.56 1.71e-28 Bipolar disorder (body mass index interaction); CRC cis rs2976388 0.647 rs2572906 chr8:143798269 G/A cg20041105 chr8:143859282 LYNX1 0.43 7.85 0.4 5.73e-14 Urinary tract infection frequency; CRC cis rs2276314 0.857 rs62101394 chr18:33592299 C/T cg05985134 chr18:33552581 C18orf21 0.45 6.2 0.32 1.7e-9 Endometriosis;Drug-induced torsades de pointes; CRC cis rs2032447 0.765 rs6942072 chr6:26014987 A/G cg17691542 chr6:26056736 HIST1H1C 0.43 6.03 0.32 4.45e-9 Intelligence (multi-trait analysis); CRC cis rs6952808 0.500 rs3800902 chr7:2144378 C/T cg02951883 chr7:2050386 MAD1L1 -0.67 -10.44 -0.5 3.05e-22 Bipolar disorder and schizophrenia; CRC cis rs2882667 0.858 rs10900856 chr5:138417746 C/T cg09476006 chr5:138032270 NA -0.47 -7.35 -0.38 1.61e-12 Age-related hearing impairment (SNP x SNP interaction); CRC trans rs9329221 0.506 rs6993610 chr8:10330994 C/G cg16141378 chr3:129829833 LOC729375 0.41 6.02 0.31 4.75e-9 Neuroticism; CRC cis rs7149337 0.869 rs10137445 chr14:51694416 G/A cg03361068 chr14:51561562 TRIM9 0.28 5.73 0.3 2.23e-8 Cancer; CRC cis rs9811920 0.609 rs793460 chr3:99615733 G/A cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G 0.46 6.18 0.32 1.87e-9 Axial length; CRC cis rs10971721 0.822 rs10971754 chr9:33871712 G/A cg13495928 chr9:33750294 PRSS3 0.56 5.95 0.31 6.96e-9 Body mass index; CRC cis rs7107174 0.786 rs4945262 chr11:77990831 T/C cg02023728 chr11:77925099 USP35 0.48 7.04 0.36 1.16e-11 Testicular germ cell tumor; CRC cis rs2239547 0.522 rs9311485 chr3:52987645 T/G cg18404041 chr3:52824283 ITIH1 0.32 6.32 0.33 8.59e-10 Schizophrenia; CRC trans rs7267979 0.816 rs6037158 chr20:25595466 C/A cg17903999 chr18:56338584 MALT1 -0.42 -6.91 -0.36 2.54e-11 Liver enzyme levels (alkaline phosphatase); CRC cis rs10504229 1.000 rs113379801 chr8:58173686 C/G cg02725872 chr8:58115012 NA -0.39 -6.78 -0.35 5.63e-11 Developmental language disorder (linguistic errors); CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg18426487 chr10:35379348 CUL2 -0.39 -6.13 -0.32 2.46e-9 Myopia (pathological); CRC cis rs6952808 0.564 rs73038441 chr7:2139286 T/C cg21782813 chr7:2030301 MAD1L1 0.54 9.45 0.46 6.57e-19 Bipolar disorder and schizophrenia; CRC cis rs17666538 0.535 rs7822126 chr8:643810 A/G cg23958373 chr8:599963 NA 0.66 6.92 0.36 2.37e-11 IgG glycosylation; CRC trans rs57590327 0.503 rs12497231 chr3:81519291 A/G cg23387109 chr10:94051229 MARCH5;CPEB3 -0.45 -6.03 -0.32 4.51e-9 Extraversion; CRC cis rs870825 0.929 rs72689261 chr4:185590897 C/A cg04058563 chr4:185651563 MLF1IP 0.56 5.89 0.31 9.54e-9 Blood protein levels; CRC cis rs9296095 0.554 rs12214883 chr6:33513968 A/G cg14003231 chr6:33640908 ITPR3 0.55 8.08 0.41 1.25e-14 Platelet count; CRC cis rs1005277 0.579 rs2505197 chr10:38393310 T/C cg00409905 chr10:38381863 ZNF37A -0.68 -11.32 -0.53 2.64e-25 Extrinsic epigenetic age acceleration; CRC cis rs2976388 0.609 rs2572899 chr8:143785549 A/G cg22687807 chr8:143858763 LYNX1 0.51 9.1 0.45 8.56e-18 Urinary tract infection frequency; CRC cis rs9733 0.650 rs11204684 chr1:150608894 A/G cg18016565 chr1:150552671 MCL1 -0.44 -6.53 -0.34 2.44e-10 Tonsillectomy; CRC cis rs7917772 0.503 rs746552 chr10:104342501 A/G cg11453585 chr10:104263688 ACTR1A;SUFU 0.88 16.18 0.67 1e-43 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC cis rs282587 0.597 rs408247 chr13:113405738 C/A cg04656015 chr13:113407548 ATP11A 0.6 7.31 0.37 2.04e-12 Glycated hemoglobin levels; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg22857567 chr1:33116716 RBBP4;ZBTB8OS -0.39 -5.97 -0.31 6.02e-9 Myopia (pathological); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg05815920 chr10:103880348 LDB1 0.39 6.68 0.35 1e-10 Liver disease severity in Alagille syndrome; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg18320648 chr2:152266336 RIF1 0.41 6.52 0.34 2.57e-10 Liver disease severity in Alagille syndrome; CRC cis rs4964805 0.865 rs4964780 chr12:104206859 A/G cg02344784 chr12:104178138 NT5DC3 0.49 6.9 0.36 2.6e-11 Attention deficit hyperactivity disorder; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg06646493 chr1:116519019 SLC22A15 0.39 6.8 0.35 4.86e-11 Liver disease severity in Alagille syndrome; CRC cis rs262150 0.567 rs2040897 chr7:158803848 C/T cg12590608 chr7:158785262 NA 0.33 5.85 0.31 1.2e-8 Facial morphology (factor 20); CRC cis rs4132509 0.744 rs10927065 chr1:243914611 G/T cg21452805 chr1:244014465 NA 0.54 7.02 0.36 1.28e-11 RR interval (heart rate); CRC cis rs6951245 0.938 rs11764937 chr7:1092074 C/T cg04025307 chr7:1156635 C7orf50 0.57 6.12 0.32 2.66e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs4665809 1.000 rs6546766 chr2:26328680 T/C cg22920501 chr2:26401640 FAM59B -0.52 -6.97 -0.36 1.78e-11 Gut microbiome composition (summer); CRC trans rs208520 0.690 rs207077 chr6:66769855 A/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.02 -13.78 -0.6 1.95e-34 Exhaled nitric oxide output; CRC cis rs7264396 0.563 rs2425100 chr20:34310115 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.49 -6.77 -0.35 6.03e-11 Total cholesterol levels; CRC cis rs1218582 0.651 rs4845396 chr1:154828409 A/G cg06221963 chr1:154839813 KCNN3 0.53 8.55 0.43 4.62e-16 Prostate cancer; CRC cis rs1697139 0.583 rs1428475 chr5:66543954 G/T cg16691251 chr5:66510806 NA 0.44 7.76 0.39 1.05e-13 Breast cancer; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg23889391 chr6:46138699 ENPP5 0.44 6.3 0.33 9.76e-10 Anxiety disorder; CRC cis rs13108904 0.539 rs13140926 chr4:1340939 G/A cg00684032 chr4:1343700 KIAA1530 0.61 8.35 0.42 1.93e-15 Obesity-related traits; CRC cis rs9467603 1.000 rs9467606 chr6:25809218 A/G cg08501292 chr6:25962987 TRIM38 1.08 9.37 0.46 1.19e-18 Intelligence (multi-trait analysis); CRC cis rs875971 0.662 rs448725 chr7:65514628 A/G cg18876405 chr7:65276391 NA 0.51 8.79 0.44 8.65e-17 Aortic root size; CRC cis rs9814567 0.964 rs9820425 chr3:134223018 G/C cg06541857 chr3:134203789 ANAPC13;CEP63 -0.39 -5.78 -0.3 1.73e-8 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC trans rs629535 0.590 rs56200825 chr8:70123450 G/A cg21567404 chr3:27674614 NA -0.93 -13.42 -0.59 4.77e-33 Dupuytren's disease; CRC trans rs11722228 0.521 rs62288520 chr4:10099674 G/A cg26043149 chr18:55253948 FECH 1.14 17.46 0.69 9.11e-49 Gout;Urate levels;Serum uric acid levels; CRC cis rs10155981 0.510 rs4722157 chr7:22583941 G/A cg05062323 chr7:22590069 NA -0.61 -6.81 -0.35 4.59e-11 Bilirubin levels; CRC cis rs1799949 1.000 rs2271574 chr17:41327648 T/C cg01879757 chr17:41196368 BRCA1 -0.43 -6.62 -0.34 1.51e-10 Menopause (age at onset); CRC cis rs8077889 0.917 rs4793037 chr17:41914826 C/T cg16892393 chr17:41919603 NA 0.57 8.35 0.42 1.9e-15 Triglycerides; CRC trans rs11031096 0.714 rs3794049 chr11:4145658 A/G cg22978087 chr8:24814126 NEFL 0.33 6.08 0.32 3.36e-9 Mean corpuscular volume;Mean corpuscular hemoglobin; CRC cis rs853679 0.550 rs9295762 chr6:28155418 C/T cg21251018 chr6:28226885 NKAPL -0.46 -6.48 -0.34 3.3e-10 Depression; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg26980138 chr12:68726465 MDM1 0.51 7.19 0.37 4.28e-12 Response to antipsychotic treatment; CRC cis rs9311474 0.597 rs6778735 chr3:52565100 T/C cg07507251 chr3:52567010 NT5DC2 0.49 7.84 0.4 6.13e-14 Electroencephalogram traits; CRC cis rs9868809 0.505 rs73080312 chr3:48737847 C/T cg01304814 chr3:48885189 PRKAR2A 0.89 6.57 0.34 1.92e-10 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; CRC cis rs10046574 0.519 rs10265128 chr7:135211446 A/G cg27474649 chr7:135195673 CNOT4 0.61 5.95 0.31 7.03e-9 Peripheral arterial disease (traffic-related air pollution interaction); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg00744199 chr3:150479830 SIAH2 0.42 6.16 0.32 2.18e-9 Intelligence (multi-trait analysis); CRC cis rs4363385 0.510 rs7543689 chr1:153046803 A/T cg25856811 chr1:152973957 SPRR3 -0.21 -5.69 -0.3 2.74e-8 Inflammatory skin disease; CRC cis rs8038465 0.622 rs2509 chr15:73859488 A/T cg15420318 chr15:73925796 NPTN -0.44 -7.14 -0.37 6.12e-12 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs10876993 0.890 rs799575 chr12:58069107 A/G cg15848620 chr12:58087721 OS9 -0.59 -8.27 -0.41 3.31e-15 Celiac disease or Rheumatoid arthritis; CRC cis rs4665809 0.531 rs34081866 chr2:26475940 C/T cg25036284 chr2:26402008 FAM59B 0.64 8.53 0.43 5.5e-16 Gut microbiome composition (summer); CRC cis rs270601 0.770 rs61352298 chr5:131600589 G/C cg24060327 chr5:131705240 SLC22A5 -0.4 -6.21 -0.32 1.59e-9 Acylcarnitine levels; CRC cis rs908922 0.582 rs1856121 chr1:152512169 A/T cg09873164 chr1:152488093 CRCT1 0.37 6.19 0.32 1.81e-9 Hair morphology; CRC cis rs1865760 0.865 rs9467647 chr6:25957642 A/G cg17691542 chr6:26056736 HIST1H1C 0.55 8.41 0.42 1.25e-15 Height; CRC cis rs728616 0.510 rs12416084 chr10:81749215 A/G cg05935833 chr10:81318306 SFTPA2 -0.53 -6.97 -0.36 1.72e-11 Chronic obstructive pulmonary disease-related biomarkers; CRC trans rs1997103 1.000 rs9642578 chr7:55400320 A/G cg20935933 chr6:143382018 AIG1 0.53 6.95 0.36 2.01e-11 QRS interval (sulfonylurea treatment interaction); CRC trans rs7267979 0.903 rs6107015 chr20:25216764 G/A cg17903999 chr18:56338584 MALT1 -0.41 -6.56 -0.34 2.11e-10 Liver enzyme levels (alkaline phosphatase); CRC cis rs7107174 0.901 rs11237459 chr11:78056273 A/C cg02023728 chr11:77925099 USP35 0.47 8.31 0.42 2.53e-15 Testicular germ cell tumor; CRC cis rs9462027 0.628 rs2477508 chr6:34703695 A/G cg07306190 chr6:34760872 UHRF1BP1 0.33 5.81 0.3 1.49e-8 Systemic lupus erythematosus; CRC cis rs1451375 0.572 rs896309 chr7:50545022 A/G cg14593290 chr7:50529359 DDC -0.62 -8.2 -0.41 5.53e-15 Malaria; CRC cis rs9914988 1.000 rs6803 chr17:27187789 C/T cg20469991 chr17:27169893 C17orf63 0.47 5.88 0.31 1.01e-8 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC trans rs2228479 0.557 rs62054639 chr16:89821489 C/T cg24644049 chr4:85504048 CDS1 0.86 6.93 0.36 2.29e-11 Skin colour saturation; CRC cis rs1185460 0.967 rs1307145 chr11:118950217 C/G cg23280166 chr11:118938394 VPS11 0.43 6.33 0.33 8.21e-10 Coronary artery disease; CRC cis rs1552244 0.882 rs13089863 chr3:10032259 G/T cg00166722 chr3:10149974 C3orf24 -0.6 -7.59 -0.39 3.35e-13 Alzheimer's disease; CRC cis rs9399135 0.967 rs9376082 chr6:135346389 T/A cg22676075 chr6:135203613 NA 0.4 6.22 0.32 1.5e-9 Red blood cell count; CRC cis rs910316 0.523 rs4026175 chr14:75502240 C/A cg08847533 chr14:75593920 NEK9 0.83 12.94 0.58 3.07e-31 Height; CRC trans rs10838798 0.523 rs2019093 chr11:48196553 G/A cg15704280 chr7:45808275 SEPT13 -0.49 -6.87 -0.35 3.3e-11 Height; CRC cis rs8180040 1.000 rs807936 chr3:47322496 C/T cg02527881 chr3:46936655 PTH1R -0.4 -7.49 -0.38 6.52e-13 Colorectal cancer; CRC cis rs758324 0.947 rs380182 chr5:131319036 A/G cg25547332 chr5:131281432 NA -0.37 -5.62 -0.3 4.04e-8 Alzheimer's disease in APOE e4- carriers; CRC cis rs73206853 0.698 rs1018133 chr12:111121302 G/C cg12870014 chr12:110450643 ANKRD13A 0.81 9.1 0.45 8.98e-18 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC cis rs1862618 0.853 rs43184 chr5:56141777 G/C cg03609598 chr5:56110824 MAP3K1 -0.82 -9.93 -0.48 1.76e-20 Initial pursuit acceleration; CRC cis rs6831352 0.918 rs13110764 chr4:100062466 C/T cg13256891 chr4:100009986 ADH5 -0.66 -8.98 -0.44 2.17e-17 Alcohol dependence; CRC cis rs13108904 0.557 rs1680030 chr4:1245500 A/T cg05025164 chr4:1340916 KIAA1530 -0.49 -6.8 -0.35 5.01e-11 Obesity-related traits; CRC cis rs896854 0.967 rs896853 chr8:95960855 G/C cg09323728 chr8:95962352 TP53INP1 -0.44 -7.34 -0.38 1.7e-12 Type 2 diabetes; CRC cis rs1538970 0.816 rs3790583 chr1:45956828 C/G cg05343316 chr1:45956843 TESK2 0.75 9.79 0.48 4.94e-20 Platelet count; CRC cis rs7804356 1.000 rs3801805 chr7:26897640 A/G cg03456212 chr7:26904342 SKAP2 -0.5 -5.69 -0.3 2.77e-8 Type 1 diabetes; CRC cis rs11758351 1.000 rs76329209 chr6:26196430 A/G cg22723502 chr6:26240528 HIST1H4F -0.38 -5.83 -0.31 1.35e-8 Gout;Renal underexcretion gout; CRC cis rs12762955 0.687 rs4880470 chr10:1077480 G/A cg20503657 chr10:835505 NA -0.53 -8.31 -0.42 2.53e-15 Response to angiotensin II receptor blocker therapy; CRC cis rs13191362 1.000 rs13204439 chr6:163015358 A/C cg21926612 chr6:163149169 PACRG;PARK2 -0.73 -10.5 -0.5 1.98e-22 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs2282802 0.711 rs1864970 chr5:139633042 T/C cg26211634 chr5:139558579 C5orf32 0.44 7.61 0.39 2.97e-13 Intelligence (multi-trait analysis); CRC cis rs1799949 1.000 rs2271574 chr17:41327648 T/C cg23758822 chr17:41437982 NA 0.8 13.62 0.6 8.51e-34 Menopause (age at onset); CRC cis rs10504229 0.593 rs76922080 chr8:57985837 C/G cg11062466 chr8:58055876 NA 0.52 6.23 0.32 1.47e-9 Developmental language disorder (linguistic errors); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg23598254 chr1:15736141 EFHD2 0.43 6.09 0.32 3.22e-9 Intelligence (multi-trait analysis); CRC cis rs4713118 0.699 rs200978 chr6:27853168 C/G cg15845792 chr6:28175446 NA 0.79 10.3 0.49 9.39e-22 Parkinson's disease; CRC cis rs7605827 0.866 rs35237017 chr2:15615704 T/C cg19274914 chr2:15703543 NA 0.38 5.8 0.3 1.57e-8 Educational attainment (years of education); CRC cis rs2836950 0.527 rs2836948 chr21:40599677 T/C cg17971929 chr21:40555470 PSMG1 -0.61 -8.92 -0.44 3.38e-17 Menarche (age at onset); CRC cis rs6484504 0.600 rs2761593 chr11:31326752 G/T cg14844989 chr11:31128820 NA 0.36 6.53 0.34 2.46e-10 Red blood cell count; CRC cis rs2032447 0.670 rs198815 chr6:26127271 A/G cg03517284 chr6:25882590 NA 0.42 5.68 0.3 2.92e-8 Intelligence (multi-trait analysis); CRC cis rs10751667 0.560 rs10902265 chr11:1003642 G/A cg23136738 chr11:925521 AP2A2 -0.4 -6.24 -0.33 1.34e-9 Alzheimer's disease (late onset); CRC cis rs2836974 0.644 rs7281853 chr21:40693490 A/G cg11644478 chr21:40555479 PSMG1 -0.65 -9.79 -0.48 4.89e-20 Cognitive function; CRC cis rs6964587 0.869 rs7810391 chr7:91520227 G/A cg17063962 chr7:91808500 NA -0.73 -12.1 -0.55 4.12e-28 Breast cancer; CRC cis rs2952156 0.959 rs2952151 chr17:37828496 T/C cg20243544 chr17:37824526 PNMT 0.59 9.14 0.45 6.54e-18 Asthma; CRC cis rs870825 0.616 rs2310110 chr4:185647902 G/A cg04058563 chr4:185651563 MLF1IP 0.72 9.3 0.46 2.04e-18 Blood protein levels; CRC cis rs7224685 0.501 rs4790171 chr17:4022899 T/C cg09695851 chr17:3907499 NA -0.78 -14.06 -0.61 1.71e-35 Type 2 diabetes; CRC cis rs736408 0.677 rs2286798 chr3:52821177 G/T cg18404041 chr3:52824283 ITIH1 0.41 8.59 0.43 3.5e-16 Bipolar disorder; CRC cis rs6504622 1.000 rs6504622 chr17:45019731 C/T cg16759221 chr17:45003025 GOSR2 -0.45 -7.12 -0.37 6.76e-12 Orofacial clefts; CRC cis rs78456975 1.000 rs6708604 chr2:1556887 C/T cg12573674 chr2:1569213 NA -0.77 -7.94 -0.4 3.17e-14 Placebo response in major depressive disorder (% change in symptom score); CRC trans rs2243480 1.000 rs1546059 chr7:65654709 C/A cg10756647 chr7:56101905 PSPH -0.76 -7.72 -0.39 1.4e-13 Diabetic kidney disease; CRC cis rs875971 0.862 rs4718330 chr7:65715243 G/A cg00343986 chr7:65444356 GUSB -0.42 -5.94 -0.31 7.23e-9 Aortic root size; CRC cis rs12142240 0.698 rs6429599 chr1:46827871 G/A cg14993813 chr1:46806288 NSUN4 -0.49 -6.24 -0.33 1.37e-9 Menopause (age at onset); CRC cis rs6502050 0.799 rs11491185 chr17:80151101 C/T cg13198984 chr17:80129470 CCDC57 0.43 7.56 0.38 3.92e-13 Life satisfaction; CRC cis rs637571 0.584 rs659824 chr11:65636509 A/G cg04055107 chr11:65626734 MUS81;CFL1 -0.46 -6.58 -0.34 1.82e-10 Eosinophil percentage of white cells; CRC cis rs231513 1.000 rs231526 chr17:41951277 T/C cg16892393 chr17:41919603 NA -0.53 -5.66 -0.3 3.3e-8 Cognitive function; CRC cis rs4363385 0.747 rs12048412 chr1:152977092 A/T cg25856811 chr1:152973957 SPRR3 -0.24 -6.67 -0.35 1.08e-10 Inflammatory skin disease; CRC cis rs2625529 0.590 rs12442886 chr15:72473611 T/C cg16672083 chr15:72433130 SENP8 0.41 6.01 0.31 5.02e-9 Red blood cell count; CRC cis rs2976388 0.647 rs2585154 chr8:143783485 C/T cg22687807 chr8:143858763 LYNX1 0.47 8.39 0.42 1.45e-15 Urinary tract infection frequency; CRC cis rs2235544 0.513 rs10158824 chr1:54480398 C/G cg25741118 chr1:54482237 LDLRAD1 0.21 5.89 0.31 9.63e-9 Multiple myeloma (hyperdiploidy);Thyroid hormone levels; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg18278596 chr14:105915860 MTA1 -0.39 -6.12 -0.32 2.64e-9 Liver disease severity in Alagille syndrome; CRC cis rs61996546 0.622 rs11639008 chr15:26842107 C/G cg15066197 chr15:26874202 GABRB3 -0.39 -5.89 -0.31 9.47e-9 Response to methotrexate in juvenile idiopathic arthritis; CRC cis rs3806843 0.868 rs2563281 chr5:140131219 T/A cg16607685 chr5:140181889 PCDHA2;PCDHA1;PCDHA3 0.26 5.93 0.31 7.73e-9 Depressive symptoms (multi-trait analysis); CRC cis rs9309711 0.666 rs6723126 chr2:3484500 T/C cg15506890 chr2:3487001 NA -0.53 -8.61 -0.43 3.09e-16 Neurofibrillary tangles; CRC cis rs561341 1.000 rs2344312 chr17:30243583 G/T cg23018236 chr17:30244563 NA -0.46 -6.46 -0.34 3.7e-10 Hip circumference adjusted for BMI; CRC cis rs6499255 0.951 rs12595869 chr16:69729794 T/G cg04110750 chr16:69646130 NFAT5 -0.56 -7.71 -0.39 1.48e-13 IgE levels; CRC cis rs9916302 0.706 rs8182252 chr17:37727950 T/C cg07936489 chr17:37558343 FBXL20 0.92 12.98 0.58 2.1e-31 Glomerular filtration rate (creatinine); CRC cis rs7666738 0.830 rs6855393 chr4:99056534 T/C cg17366294 chr4:99064904 C4orf37 0.46 7.72 0.39 1.4e-13 Colonoscopy-negative controls vs population controls; CRC cis rs12760731 0.720 rs7537811 chr1:178276421 A/T cg00404053 chr1:178313656 RASAL2 0.81 9.47 0.46 5.85e-19 Obesity-related traits; CRC cis rs2072510 0.593 rs2660838 chr12:96416383 T/C cg22491680 chr12:96389547 HAL -0.46 -5.73 -0.3 2.23e-8 Metabolite levels (small molecules and protein measures); CRC cis rs10883723 0.810 rs913025 chr10:104276043 C/T cg22532475 chr10:104410764 TRIM8 -0.36 -6.62 -0.34 1.45e-10 Allergic disease (asthma, hay fever or eczema); CRC cis rs40363 0.716 rs9926612 chr16:3540968 A/C cg21433313 chr16:3507492 NAT15 -0.69 -6.25 -0.33 1.26e-9 Tuberculosis; CRC cis rs9916302 0.904 rs2338798 chr17:37547269 T/C cg07936489 chr17:37558343 FBXL20 0.78 11.71 0.54 1.02e-26 Glomerular filtration rate (creatinine); CRC cis rs11628318 0.614 rs7145737 chr14:103121784 T/A cg23071808 chr14:103021642 NA 0.63 7.04 0.36 1.14e-11 Platelet count; CRC cis rs7537052 0.669 rs2296263 chr1:36641729 C/T cg24686825 chr1:36642396 MAP7D1 -0.52 -7.31 -0.37 1.98e-12 Schizophrenia; CRC cis rs6088580 0.634 rs6088508 chr20:33060081 A/G cg08999081 chr20:33150536 PIGU 0.61 11.45 0.53 9.05e-26 Glomerular filtration rate (creatinine); CRC cis rs514406 0.861 rs35517489 chr1:53304062 G/C cg08859206 chr1:53392774 SCP2 -0.42 -6.57 -0.34 1.97e-10 Monocyte count; CRC cis rs736408 0.609 rs13082960 chr3:52785168 A/C cg10802521 chr3:52805072 NEK4 -0.58 -8.87 -0.44 4.88e-17 Bipolar disorder; CRC cis rs7937682 0.632 rs4936834 chr11:111764017 T/A cg19812747 chr11:111475976 SIK2 0.44 6.34 0.33 7.7e-10 Primary sclerosing cholangitis; CRC cis rs10504229 0.906 rs72650894 chr8:58179734 C/T cg22535103 chr8:58192502 C8orf71 -0.82 -12.27 -0.56 9.63e-29 Developmental language disorder (linguistic errors); CRC cis rs9322193 0.923 rs9688938 chr6:150110077 G/A cg13206674 chr6:150067644 NUP43 0.57 8.14 0.41 8.29e-15 Lung cancer; CRC cis rs6831352 0.918 rs35784540 chr4:100061692 T/A cg12011299 chr4:100065546 ADH4 -0.51 -9.6 -0.47 2.04e-19 Alcohol dependence; CRC cis rs875971 0.862 rs1167390 chr7:65575893 G/A cg12463550 chr7:65579703 CRCP -0.52 -7.4 -0.38 1.14e-12 Aortic root size; CRC cis rs1448094 0.512 rs7137596 chr12:86239884 C/G cg18827107 chr12:86230957 RASSF9 -0.46 -7.54 -0.38 4.63e-13 Major depressive disorder; CRC cis rs7208859 0.673 rs56146117 chr17:29153325 C/T cg13385521 chr17:29058706 SUZ12P 0.65 7.38 0.38 1.32e-12 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC trans rs875971 0.660 rs2191268 chr7:66110224 C/T cg04703844 chr8:74207197 RPL7;RDH10 -0.39 -6.03 -0.32 4.31e-9 Aortic root size; CRC cis rs453193 0.726 rs443997 chr2:8448422 G/A cg12167548 chr2:8464763 NA 0.29 5.76 0.3 1.98e-8 Granulocyte percentage of myeloid white cells; CRC cis rs2629540 0.806 rs10901812 chr10:126419384 A/G cg08799069 chr10:126477246 METTL10 -0.63 -8.26 -0.41 3.64e-15 Cocaine dependence; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg17585343 chr11:43702103 HSD17B12 0.39 5.99 0.31 5.4e-9 Intelligence (multi-trait analysis); CRC cis rs12594515 1.000 rs12906442 chr15:45985254 C/A cg22117107 chr15:45993392 NA -0.44 -8.99 -0.44 2.05e-17 Waist circumference;Weight; CRC cis rs9322193 0.923 rs1572229 chr6:150064977 T/A cg00933542 chr6:150070202 PCMT1 0.32 6.62 0.34 1.5e-10 Lung cancer; CRC cis rs9487051 0.766 rs351748 chr6:109532296 C/T cg21918786 chr6:109611834 NA 0.36 6.28 0.33 1.07e-9 Reticulocyte fraction of red cells; CRC cis rs6546550 0.901 rs6716937 chr2:70127229 G/A cg02498382 chr2:70120550 SNRNP27 -0.56 -9.52 -0.46 3.78e-19 Prevalent atrial fibrillation; CRC cis rs11148252 0.819 rs7336679 chr13:53043333 G/A cg12458913 chr13:53173898 NA 0.52 7.91 0.4 3.88e-14 Lewy body disease; CRC cis rs6547741 1.000 rs2384654 chr2:27847364 C/T cg27432699 chr2:27873401 GPN1 0.76 13.4 0.59 5.88e-33 Oral cavity cancer; CRC trans rs6819266 0.636 rs13148734 chr4:63330858 A/G cg11105980 chr13:37393381 RFXAP 0.38 5.99 0.31 5.41e-9 Age-related macular degeneration; CRC trans rs13046373 0.905 rs4816372 chr21:32077414 A/T cg18061543 chr17:80864463 TBCD -0.43 -6.59 -0.34 1.77e-10 HDL cholesterol; CRC cis rs853679 0.517 rs9368553 chr6:28082265 T/C cg21251018 chr6:28226885 NKAPL 0.48 6.19 0.32 1.84e-9 Depression; CRC cis rs35146811 0.660 rs3779046 chr7:99779243 A/G cg00553149 chr7:99775558 STAG3;GPC2 0.24 5.9 0.31 8.81e-9 Coronary artery disease; CRC cis rs4631830 0.900 rs4630241 chr10:51532751 G/A cg20129853 chr10:51489980 NA -0.35 -5.73 -0.3 2.26e-8 Prostate-specific antigen levels; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg23901904 chr1:10855062 CASZ1 0.46 6.04 0.32 4.27e-9 Thyroid stimulating hormone; CRC cis rs73198271 0.813 rs56007835 chr8:8610026 G/A cg06636001 chr8:8085503 FLJ10661 -0.45 -5.77 -0.3 1.79e-8 Bone ultrasound measurement (broadband ultrasound attenuation); CRC cis rs3772130 0.624 rs56382357 chr3:121452339 T/C cg20356878 chr3:121714668 ILDR1 0.56 10.19 0.49 2.29e-21 Cognitive performance; CRC trans rs877282 0.842 rs35872126 chr10:764545 G/A cg22713356 chr15:30763199 NA 1.29 15.31 0.65 2.44e-40 Uric acid levels; CRC trans rs9329221 0.741 rs534523 chr8:9884999 C/G cg06636001 chr8:8085503 FLJ10661 -0.56 -8.81 -0.44 7.23e-17 Neuroticism; CRC trans rs6600671 0.902 rs2222371 chr1:121289118 T/C cg00646200 chr1:148855367 NA -0.34 -6.09 -0.32 3.07e-9 Hip geometry; CRC cis rs10911251 0.528 rs6669199 chr1:183082421 C/A ch.1.3577855R chr1:183094577 LAMC1 0.88 15.5 0.65 4.51e-41 Colorectal cancer; CRC cis rs5753618 0.583 rs5749270 chr22:31812853 C/T cg07713946 chr22:31675144 LIMK2 0.42 6.29 0.33 1.02e-9 Colorectal cancer; CRC cis rs1878931 0.858 rs3760083 chr16:3450052 C/T cg26668626 chr16:3451006 ZNF174;ZNF434 -0.8 -12.49 -0.57 1.43e-29 Body mass index (adult); CRC cis rs2839186 0.500 rs13049893 chr21:47707054 C/T cg20399509 chr21:47717575 C21orf57 -0.36 -5.74 -0.3 2.1e-8 Testicular germ cell tumor; CRC cis rs6582630 0.576 rs2387836 chr12:38560070 A/G cg26384229 chr12:38710491 ALG10B 0.52 7.53 0.38 5.08e-13 Drug-induced liver injury (flucloxacillin); CRC cis rs798554 1.000 rs798559 chr7:2758341 T/C cg04166393 chr7:2884313 GNA12 0.45 6.06 0.32 3.65e-9 Height; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg20503117 chr3:5164013 ARL8B 0.52 6.61 0.34 1.51e-10 Thyroid stimulating hormone; CRC cis rs875971 0.862 rs778686 chr7:65835910 C/T cg18876405 chr7:65276391 NA 0.51 8.47 0.42 8.21e-16 Aortic root size; CRC cis rs6951245 0.882 rs10256720 chr7:1210825 C/G cg21664854 chr7:1097933 C7orf50;GPR146 0.69 7.98 0.4 2.49e-14 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs17270561 0.609 rs9348692 chr6:25720812 A/G cg17691542 chr6:26056736 HIST1H1C 0.66 8.31 0.42 2.57e-15 Iron status biomarkers; CRC cis rs1862618 0.671 rs2591970 chr5:56232595 T/C cg12311346 chr5:56204834 C5orf35 0.65 9.7 0.47 9.98e-20 Initial pursuit acceleration; CRC cis rs9487051 0.872 rs7772602 chr6:109608661 C/G cg01475377 chr6:109611718 NA 0.48 9.14 0.45 6.66e-18 Reticulocyte fraction of red cells; CRC cis rs2227564 1 rs2227564 chr10:75673101 C/T cg00564723 chr10:75632066 CAMK2G 0.28 6.26 0.33 1.23e-9 Crohn's disease;Inflammatory bowel disease; CRC cis rs853679 0.517 rs9393888 chr6:28059217 G/C cg03623178 chr6:28175578 NA 0.96 12.48 0.57 1.62e-29 Depression; CRC cis rs7202877 0.706 rs247447 chr16:75486648 A/G cg03315344 chr16:75512273 CHST6 -0.54 -6.2 -0.32 1.72e-9 Type 2 diabetes;Type 1 diabetes; CRC cis rs10504229 0.683 rs10504223 chr8:58140944 G/A cg24829409 chr8:58192753 C8orf71 -0.55 -8.03 -0.4 1.71e-14 Developmental language disorder (linguistic errors); CRC cis rs709400 1.000 rs7150141 chr14:104129352 G/A cg12935359 chr14:103987150 CKB -0.37 -6.18 -0.32 1.88e-9 Body mass index; CRC cis rs10788264 0.544 rs911786 chr10:124017583 C/G cg09507567 chr10:124027408 NA 0.35 7.53 0.38 5e-13 Total body bone mineral density; CRC cis rs7428 0.962 rs3637 chr2:85549874 A/G cg24342717 chr2:85555507 TGOLN2 -0.49 -6.91 -0.36 2.52e-11 Ear protrusion; CRC cis rs62064224 0.509 rs2302276 chr17:30791503 C/T cg25809561 chr17:30822961 MYO1D 0.58 10.54 0.5 1.44e-22 Schizophrenia; CRC cis rs6918586 0.616 rs198836 chr6:26113616 T/A cg18357526 chr6:26021779 HIST1H4A -0.49 -7.39 -0.38 1.21e-12 Schizophrenia; CRC cis rs1218582 0.804 rs4845678 chr1:154853295 A/G cg03351412 chr1:154909251 PMVK 0.54 8.73 0.43 1.35e-16 Prostate cancer; CRC cis rs10256972 0.681 rs12702016 chr7:1129392 C/T cg23708337 chr7:1209742 NA 0.43 6.46 0.34 3.68e-10 Longevity;Endometriosis; CRC cis rs7020830 0.898 rs12555207 chr9:37315476 C/T cg14294708 chr9:37120828 ZCCHC7 1.13 24.06 0.8 1.68e-74 Schizophrenia; CRC cis rs1538970 0.816 rs11211124 chr1:45962409 T/C cg05343316 chr1:45956843 TESK2 0.75 9.77 0.47 5.96e-20 Platelet count; CRC cis rs6429082 0.818 rs167092 chr1:235642359 A/G cg26050004 chr1:235667680 B3GALNT2 0.57 7.85 0.4 5.91e-14 Adiposity; CRC cis rs1506636 1.000 rs2215553 chr7:123318478 G/T cg03229431 chr7:123269106 ASB15 -0.75 -12.09 -0.55 4.23e-28 Plateletcrit;Platelet count; CRC cis rs734999 0.545 rs7368105 chr1:2556548 C/T cg20673091 chr1:2541236 MMEL1 0.37 5.94 0.31 7.18e-9 Ulcerative colitis; CRC cis rs3733585 0.699 rs7663097 chr4:9966791 T/C cg00071950 chr4:10020882 SLC2A9 -0.55 -9.63 -0.47 1.67e-19 Cleft plate (environmental tobacco smoke interaction); CRC trans rs10838798 0.504 rs11039673 chr11:48335156 G/A cg03929089 chr4:120376271 NA -0.46 -6.45 -0.34 3.93e-10 Height; CRC cis rs13108904 0.557 rs1250086 chr4:1248051 G/A cg15763984 chr4:1342303 KIAA1530 -0.38 -5.98 -0.31 5.86e-9 Obesity-related traits; CRC cis rs6963495 0.818 rs114865717 chr7:105158526 C/T cg02135003 chr7:105160482 PUS7 -0.9 -12.2 -0.56 1.71e-28 Bipolar disorder (body mass index interaction); CRC trans rs7615952 0.512 rs34651730 chr3:125358640 T/C cg03844506 chr4:4109441 NA -0.51 -7.57 -0.39 3.88e-13 Blood pressure (smoking interaction); CRC cis rs713477 0.967 rs4901570 chr14:55915249 T/C cg21836586 chr14:55907198 TBPL2 0.31 5.62 0.3 4.1e-8 Pediatric bone mineral content (femoral neck); CRC cis rs875971 1.000 rs6945843 chr7:65734783 G/A cg11764359 chr7:65958608 NA -0.58 -9.39 -0.46 1.04e-18 Aortic root size; CRC cis rs9487051 0.714 rs9487053 chr6:109619697 T/C cg12927641 chr6:109611667 NA -0.37 -6.61 -0.34 1.57e-10 Reticulocyte fraction of red cells; CRC cis rs736408 0.561 rs2276815 chr3:52853747 C/G cg10802521 chr3:52805072 NEK4 -0.47 -6.33 -0.33 8.18e-10 Bipolar disorder; CRC trans rs1005277 0.579 rs2474580 chr10:38398713 G/A cg27523141 chr10:43048294 ZNF37B 0.49 7.21 0.37 3.76e-12 Extrinsic epigenetic age acceleration; CRC trans rs7615952 0.611 rs9681518 chr3:125615130 A/G cg07211511 chr3:129823064 LOC729375 -1.09 -12.99 -0.58 2e-31 Blood pressure (smoking interaction); CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg18222582 chr1:232765331 NA -0.48 -6.06 -0.32 3.65e-9 Diisocyanate-induced asthma; CRC trans rs916888 0.821 rs199525 chr17:44847834 T/G cg07870213 chr5:140052090 DND1 1.04 11.25 0.53 4.81e-25 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs9322193 0.923 rs62441284 chr6:150072678 C/A cg00933542 chr6:150070202 PCMT1 0.34 7.05 0.36 1.06e-11 Lung cancer; CRC cis rs561341 1.000 rs561341 chr17:30316385 T/G cg00745463 chr17:30367425 LRRC37B -0.89 -9.87 -0.48 2.65e-20 Hip circumference adjusted for BMI; CRC trans rs7647973 0.588 rs4855848 chr3:49653457 C/T cg21659725 chr3:3221576 CRBN -0.66 -7.31 -0.37 2.03e-12 Menarche (age at onset); CRC cis rs6912958 0.754 rs10755484 chr6:88244648 C/T cg12350822 chr6:88032061 C6orf162;GJB7 -0.32 -6.0 -0.31 5.3e-9 Monocyte percentage of white cells; CRC cis rs2294693 0.945 rs68031000 chr6:41008841 G/T cg14769373 chr6:40998127 UNC5CL -0.47 -6.03 -0.32 4.3e-9 Gastric cancer;Non-cardia gastric cancer; CRC cis rs8062405 0.723 rs12445744 chr16:28588395 A/C cg05139728 chr16:28306816 SBK1 -0.37 -6.12 -0.32 2.74e-9 Cognitive ability (multi-trait analysis);Cognitive ability; CRC cis rs8060686 0.641 rs116821144 chr16:68081341 A/G cg26727032 chr16:67993705 SLC12A4 -0.58 -6.55 -0.34 2.2e-10 HDL cholesterol;Metabolic syndrome; CRC cis rs73206853 0.534 rs13313219 chr12:110509461 G/A cg12870014 chr12:110450643 ANKRD13A 0.86 8.88 0.44 4.53e-17 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC cis rs11971779 0.680 rs10273527 chr7:139036598 A/C cg07862535 chr7:139043722 LUC7L2 -0.56 -7.23 -0.37 3.49e-12 Diisocyanate-induced asthma; CRC cis rs55702914 0.805 rs11888760 chr2:198243749 A/T cg10820045 chr2:198174542 NA -0.36 -6.5 -0.34 3.04e-10 Major depression and alcohol dependence; CRC cis rs1005277 0.579 rs1740749 chr10:38521646 A/G cg00409905 chr10:38381863 ZNF37A -0.62 -10.29 -0.49 1.04e-21 Extrinsic epigenetic age acceleration; CRC cis rs6076065 0.692 rs6083092 chr20:23348836 T/C cg11657817 chr20:23433608 CST11 0.43 6.19 0.32 1.75e-9 Facial morphology (factor 15, philtrum width); CRC cis rs10464366 0.571 rs13233049 chr7:39187536 C/T cg20302533 chr7:39170763 POU6F2 0.41 5.66 0.3 3.38e-8 IgG glycosylation; CRC cis rs870825 0.616 rs4444873 chr4:185628406 A/G cg04058563 chr4:185651563 MLF1IP 0.77 9.65 0.47 1.5e-19 Blood protein levels; CRC trans rs7647973 0.626 rs4855833 chr3:49657441 A/G cg21659725 chr3:3221576 CRBN -0.66 -7.41 -0.38 1.1e-12 Menarche (age at onset); CRC cis rs9487051 1.000 rs9400273 chr6:109632799 A/G cg21918786 chr6:109611834 NA -0.38 -6.43 -0.33 4.52e-10 Reticulocyte fraction of red cells; CRC cis rs10504229 0.683 rs79262965 chr8:58129826 G/T cg21724239 chr8:58056113 NA 0.74 9.41 0.46 8.98e-19 Developmental language disorder (linguistic errors); CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg02865447 chr6:90062469 UBE2J1 0.47 6.37 0.33 6.28e-10 Anxiety disorder; CRC cis rs4285028 0.948 rs12637351 chr3:121694412 A/G cg11130432 chr3:121712080 ILDR1 0.51 6.62 0.34 1.48e-10 Multiple sclerosis; CRC cis rs2742417 0.603 rs2673055 chr3:45772772 G/A cg04837898 chr3:45731254 SACM1L -0.48 -7.69 -0.39 1.74e-13 Response to anti-depressant treatment in major depressive disorder; CRC cis rs877282 0.898 rs11253346 chr10:765313 A/G cg06581033 chr10:766294 NA -0.53 -5.79 -0.3 1.61e-8 Uric acid levels; CRC cis rs9747201 0.926 rs7222764 chr17:80062698 G/A cg09264619 chr17:80180166 NA 0.52 7.45 0.38 8.22e-13 Peripheral arterial disease (traffic-related air pollution interaction); CRC trans rs7395662 0.591 rs4882012 chr11:48560597 T/A cg15704280 chr7:45808275 SEPT13 -0.48 -6.83 -0.35 4.04e-11 HDL cholesterol; CRC cis rs3768617 0.510 rs10752900 chr1:183086238 G/A ch.1.3577855R chr1:183094577 LAMC1 0.89 15.86 0.66 1.84e-42 Fuchs's corneal dystrophy; CRC cis rs9611565 0.512 rs2050033 chr22:42159229 G/T cg03806693 chr22:41940476 POLR3H 1.1 13.51 0.6 2.16e-33 Vitiligo; CRC cis rs12612619 0.667 rs7605526 chr2:27345484 A/G cg00617064 chr2:27272375 NA -0.4 -6.44 -0.33 4.3e-10 Venous thromboembolism adjusted for sickle cell variant rs77121243-T; CRC trans rs12478296 0.892 rs60042638 chr2:243038707 G/A cg18288967 chr1:45987694 PRDX1 0.68 7.48 0.38 6.93e-13 Obesity-related traits; CRC cis rs9372498 0.536 rs9481808 chr6:118784571 G/A cg07617317 chr6:118971624 C6orf204 0.52 6.4 0.33 5.29e-10 Diastolic blood pressure; CRC cis rs4319547 0.614 rs10846764 chr12:122874297 T/C cg05707623 chr12:122985044 ZCCHC8 0.77 9.41 0.46 9.09e-19 Body mass index; CRC cis rs2535633 0.631 rs2336670 chr3:52998504 T/G cg15147215 chr3:52552868 STAB1 0.43 6.93 0.36 2.18e-11 Body mass index; CRC trans rs2727020 0.521 rs1909220 chr11:49572109 T/C cg03929089 chr4:120376271 NA -0.76 -10.31 -0.49 8.86e-22 Coronary artery disease; CRC cis rs2456568 0.548 rs7113080 chr11:93657520 G/A cg26875233 chr11:93583750 C11orf90 -0.37 -7.03 -0.36 1.23e-11 Response to serotonin reuptake inhibitors in major depressive disorder; CRC cis rs875971 0.895 rs7782806 chr7:65657897 C/T cg18876405 chr7:65276391 NA -0.52 -8.74 -0.43 1.22e-16 Aortic root size; CRC cis rs9399135 0.967 rs11755229 chr6:135369913 A/G cg22676075 chr6:135203613 NA 0.38 5.86 0.31 1.11e-8 Red blood cell count; CRC cis rs875971 0.502 rs6460311 chr7:66111873 C/T cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.61 -7.74 -0.39 1.26e-13 Aortic root size; CRC trans rs4263408 0.934 rs9683743 chr4:39703194 A/C cg09496464 chr2:208904568 NA -0.39 -6.0 -0.31 5.17e-9 Plasma amyloid beta peptide concentrations (ABx-40); CRC cis rs1552244 0.882 rs13099507 chr3:10031603 G/A cg18598329 chr3:10140678 FANCD2;C3orf24 -0.74 -8.88 -0.44 4.44e-17 Alzheimer's disease; CRC cis rs67311347 1.000 rs9865348 chr3:40397658 A/C cg24209194 chr3:40518798 ZNF619 0.39 5.74 0.3 2.17e-8 Renal cell carcinoma; CRC cis rs3741404 0.560 rs12362602 chr11:63908660 G/A cg19465662 chr11:63993652 NUDT22;TRPT1 -0.66 -10.25 -0.49 1.41e-21 Platelet count; CRC cis rs801193 0.660 rs4610622 chr7:66224497 T/C cg12463550 chr7:65579703 CRCP 0.46 6.32 0.33 8.48e-10 Aortic root size; CRC cis rs3772130 0.962 rs9856641 chr3:121566859 G/A cg20356878 chr3:121714668 ILDR1 0.52 8.21 0.41 5.11e-15 Cognitive performance; CRC cis rs11719291 0.584 rs13080725 chr3:49076092 G/A cg00383909 chr3:49044727 WDR6 1.31 12.49 0.57 1.46e-29 Cognitive function; CRC cis rs4819052 0.819 rs13046807 chr21:46672286 A/G cg02159808 chr21:46707872 POFUT2;LOC642852 0.49 6.5 0.34 3.05e-10 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs116095464 0.558 rs9312956 chr5:201812 T/C cg22496380 chr5:211416 CCDC127 -0.92 -9.1 -0.45 9.11e-18 Breast cancer; CRC cis rs523522 0.962 rs3213565 chr12:120992401 C/T cg12219531 chr12:120966889 COQ5 0.69 9.07 0.45 1.08e-17 High light scatter reticulocyte count; CRC cis rs10992471 0.756 rs3758229 chr9:95078852 G/T cg13798575 chr9:95087839 CENPP;NOL8 -0.47 -6.72 -0.35 8.19e-11 Visceral adipose tissue/subcutaneous adipose tissue ratio; CRC cis rs7937682 0.737 rs679032 chr11:111423286 G/T cg09085632 chr11:111637200 PPP2R1B -0.73 -12.07 -0.55 5.16e-28 Primary sclerosing cholangitis; CRC cis rs1005277 0.579 rs2474574 chr10:38387295 C/T cg00409905 chr10:38381863 ZNF37A -0.68 -11.32 -0.53 2.64e-25 Extrinsic epigenetic age acceleration; CRC cis rs8062405 0.755 rs17707300 chr16:28593347 A/G cg16576597 chr16:28551801 NUPR1 0.53 7.59 0.39 3.37e-13 Cognitive ability (multi-trait analysis);Cognitive ability; CRC cis rs7618915 0.571 rs1961958 chr3:52585990 A/G cg08222913 chr3:52553049 STAB1 -0.34 -6.23 -0.32 1.45e-9 Bipolar disorder; CRC cis rs1552244 0.572 rs12107622 chr3:10171898 T/A cg02579736 chr3:10068473 FANCD2;CIDECP 1.04 11.89 0.55 2.36e-27 Alzheimer's disease; CRC cis rs6598955 0.543 rs881578 chr1:26536141 G/A cg04990556 chr1:26633338 UBXN11 0.82 9.54 0.47 3.22e-19 Obesity-related traits; CRC cis rs989128 0.600 rs2240218 chr17:48630580 A/T cg16068336 chr17:48637367 CACNA1G -0.49 -7.1 -0.36 7.82e-12 Type 2 diabetes; CRC cis rs9858542 0.953 rs6997 chr3:49453834 C/T cg07274523 chr3:49395745 GPX1 0.46 6.21 0.32 1.61e-9 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs6502050 0.835 rs6502068 chr17:80112223 C/T cg19223190 chr17:80058835 NA 0.39 6.16 0.32 2.07e-9 Life satisfaction; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg24877558 chr1:42801138 FOXJ3 0.36 6.12 0.32 2.59e-9 Liver disease severity in Alagille syndrome; CRC cis rs6860806 0.507 rs270601 chr5:131656997 T/C cg04518342 chr5:131593106 PDLIM4 0.44 7.12 0.37 7e-12 Breast cancer; CRC cis rs9372498 0.536 rs62422220 chr6:118923731 G/A cg01339444 chr6:118972232 C6orf204 0.55 6.2 0.32 1.69e-9 Diastolic blood pressure; CRC cis rs10504229 1.000 rs67105789 chr8:58192002 G/T cg05313129 chr8:58192883 C8orf71 -0.47 -6.99 -0.36 1.49e-11 Developmental language disorder (linguistic errors); CRC cis rs270601 0.633 rs733300 chr5:131572243 A/G cg09877947 chr5:131593287 PDLIM4 0.57 9.98 0.48 1.17e-20 Acylcarnitine levels; CRC cis rs2549003 1.000 rs2070727 chr5:131820275 C/A cg21138405 chr5:131827807 IRF1 0.57 11.38 0.53 1.59e-25 Asthma (sex interaction); CRC cis rs2439831 0.702 rs7175032 chr15:44060236 C/T cg02155558 chr15:43621948 ADAL;LCMT2 0.69 7.61 0.39 2.95e-13 Lung cancer in ever smokers; CRC cis rs11112613 0.713 rs73184084 chr12:105952615 T/A cg03607813 chr12:105948248 NA 0.78 10.91 0.52 7.6e-24 Corrected insulin response;Corrected insulin response adjusted for insulin sensitivity index; CRC cis rs2976388 0.566 rs4736373 chr8:143792357 G/C cg05569086 chr8:143859399 LYNX1 -0.43 -7.01 -0.36 1.35e-11 Urinary tract infection frequency; CRC cis rs40363 0.729 rs6501176 chr16:3522197 A/G cg00484396 chr16:3507460 NAT15 -0.52 -6.32 -0.33 8.72e-10 Tuberculosis; CRC cis rs2243480 1.000 rs465359 chr7:65558164 C/T cg18252515 chr7:66147081 NA -1.14 -13.85 -0.61 1.06e-34 Diabetic kidney disease; CRC cis rs548181 0.536 rs503288 chr11:125461787 C/T cg03464685 chr11:125439445 EI24 -0.85 -9.83 -0.48 3.6e-20 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs6684428 0.706 rs10493187 chr1:56320969 C/T cg11651538 chr1:56320950 NA -0.44 -5.65 -0.3 3.39e-8 Airflow obstruction; CRC cis rs9910055 0.529 rs228766 chr17:42186813 A/G cg09913183 chr17:42254507 C17orf65;ASB16 -0.52 -6.93 -0.36 2.29e-11 Total body bone mineral density; CRC cis rs1799949 0.773 rs2137990 chr17:41317896 T/A cg23758822 chr17:41437982 NA -0.84 -15.27 -0.64 3.52e-40 Menopause (age at onset); CRC cis rs7333181 0.649 rs914030 chr13:112240131 T/C cg27543320 chr13:112200689 NA -0.56 -9.42 -0.46 8.49e-19 Menopause (age at onset); CRC cis rs763121 0.853 rs926299 chr22:39095698 C/G cg06544989 chr22:39130855 UNC84B 0.49 7.78 0.39 9.51e-14 Menopause (age at onset); CRC cis rs6762 0.748 rs1130719 chr11:838760 T/A cg11173246 chr11:841376 TSPAN4;POLR2L -0.33 -5.61 -0.3 4.22e-8 Mean platelet volume; CRC cis rs9487051 0.700 rs9400266 chr6:109596193 T/A cg01475377 chr6:109611718 NA -0.37 -6.58 -0.34 1.85e-10 Reticulocyte fraction of red cells; CRC cis rs12545109 0.879 rs1581129 chr8:57377476 T/C cg09654669 chr8:57350985 NA -0.43 -5.83 -0.31 1.3e-8 Obesity-related traits; CRC cis rs8180040 0.676 rs11130114 chr3:47154651 T/G cg02527881 chr3:46936655 PTH1R -0.37 -6.96 -0.36 1.87e-11 Colorectal cancer; CRC cis rs6479527 1.000 rs6479528 chr9:96858429 G/A cg14459158 chr9:96720562 NA 0.43 7.52 0.38 5.31e-13 Esophageal adenocarcinoma; CRC cis rs6674970 0.966 rs4512652 chr1:151115690 G/C cg03258749 chr1:151040405 MLLT11 -0.46 -7.19 -0.37 4.32e-12 Childhood ear infection; CRC cis rs7647973 0.922 rs7620024 chr3:49451691 G/A cg20833759 chr3:49053208 WDR6;DALRD3 -0.55 -8.15 -0.41 7.66e-15 Menarche (age at onset); CRC cis rs4689388 0.926 rs4689394 chr4:6291003 C/G cg00701064 chr4:6280414 WFS1 -0.7 -11.91 -0.55 2.01e-27 Type 2 diabetes and other traits;Type 2 diabetes; CRC cis rs501120 0.584 rs61855739 chr10:44679603 G/A cg09554077 chr10:44749378 NA 0.7 7.85 0.4 5.95e-14 Coronary artery disease;Coronary heart disease; CRC cis rs4434138 0.683 rs13063160 chr3:52602274 T/C cg05573699 chr3:52720067 GNL3;PBRM1 -0.46 -6.81 -0.35 4.71e-11 Intelligence (multi-trait analysis); CRC cis rs7666738 0.830 rs60994860 chr4:99046753 G/A cg17366294 chr4:99064904 C4orf37 0.45 7.75 0.39 1.16e-13 Colonoscopy-negative controls vs population controls; CRC cis rs62103177 0.810 rs62096745 chr18:77619135 A/G cg12964065 chr18:77638022 KCNG2 0.68 7.02 0.36 1.29e-11 Opioid sensitivity; CRC cis rs9322193 0.632 rs3828700 chr6:150112169 C/G cg05861140 chr6:150128134 PCMT1 -0.43 -7.02 -0.36 1.3e-11 Lung cancer; CRC cis rs9311474 0.713 rs352170 chr3:52236077 A/G cg18099408 chr3:52552593 STAB1 -0.36 -5.85 -0.31 1.17e-8 Electroencephalogram traits; CRC cis rs26868 0.766 rs27556 chr16:2249325 T/C cg02248941 chr16:2239361 CASKIN1 0.63 11.66 0.54 1.59e-26 Height; CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg25867694 chr22:31503597 SELM 0.4 6.72 0.35 8e-11 Obesity-related traits; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg15198335 chr15:66586003 DIS3L 0.38 6.05 0.32 4.02e-9 Liver disease severity in Alagille syndrome; CRC cis rs6860806 0.507 rs273901 chr5:131694360 G/T cg11843238 chr5:131593191 PDLIM4 0.43 7.3 0.37 2.22e-12 Breast cancer; CRC cis rs9322193 0.884 rs10872648 chr6:150079835 A/G cg00933542 chr6:150070202 PCMT1 0.31 5.98 0.31 5.84e-9 Lung cancer; CRC cis rs2066819 1.000 rs2066818 chr12:56753822 C/A cg26714650 chr12:56694279 CS -1.4 -10.71 -0.51 3.56e-23 Psoriasis vulgaris; CRC cis rs1865760 0.588 rs9467658 chr6:26010881 T/G cg16482183 chr6:26056742 HIST1H1C 0.52 7.63 0.39 2.64e-13 Height; CRC trans rs783540 0.542 rs62009945 chr15:83299956 T/A cg18393722 chr15:85113863 UBE2QP1 -0.47 -6.63 -0.34 1.35e-10 Schizophrenia; CRC cis rs10504229 0.906 rs111838497 chr8:58185620 A/C cg02290350 chr8:58132656 NA -0.42 -5.96 -0.31 6.62e-9 Developmental language disorder (linguistic errors); CRC cis rs10504229 0.610 rs6993531 chr8:58147283 A/G cg05313129 chr8:58192883 C8orf71 -0.4 -5.89 -0.31 9.72e-9 Developmental language disorder (linguistic errors); CRC cis rs3760982 1.000 rs3760983 chr19:44286660 C/T cg12072164 chr19:44306565 LYPD5 -0.41 -6.42 -0.33 4.86e-10 Breast cancer (estrogen-receptor negative);Breast cancer; CRC cis rs2290405 0.527 rs7663192 chr4:923947 T/C cg10113582 chr4:905918 GAK -0.47 -6.98 -0.36 1.68e-11 Systemic sclerosis; CRC cis rs9368481 0.729 rs9379950 chr6:26961548 T/C cg10547057 chr6:26987810 LOC100270746;C6orf41 -0.41 -5.74 -0.3 2.12e-8 Autism spectrum disorder or schizophrenia; CRC cis rs12541335 0.639 rs7834182 chr8:22163112 G/A cg02463440 chr8:22132932 PIWIL2 0.5 8.81 0.44 7.15e-17 Hypertriglyceridemia; CRC cis rs1878931 0.501 rs9302871 chr16:3415512 T/C cg26668626 chr16:3451006 ZNF174;ZNF434 0.69 9.44 0.46 6.91e-19 Body mass index (adult); CRC cis rs10128264 0.902 rs2802360 chr10:80971196 C/T cg20744163 chr10:80999841 ZMIZ1 -0.44 -7.71 -0.39 1.47e-13 Response to methotrexate in juvenile idiopathic arthritis; CRC cis rs9534288 0.699 rs7139571 chr13:46662584 G/A cg15192986 chr13:46630673 CPB2 -0.71 -9.09 -0.45 9.73e-18 Blood protein levels; CRC cis rs8103278 1.000 rs36091860 chr19:46312880 G/A cg16681516 chr19:46297285 DMWD 0.36 5.84 0.31 1.26e-8 Coronary artery disease; CRC cis rs13191362 0.938 rs13192618 chr6:163132822 T/C cg14584255 chr6:163149320 PACRG;PARK2 0.4 5.95 0.31 6.82e-9 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs6748734 1.000 rs11898716 chr2:241828311 A/G cg04034577 chr2:241836375 C2orf54 -0.43 -9.16 -0.45 5.87e-18 Urinary metabolites; CRC cis rs3816788 0.620 rs11783414 chr8:21773384 A/G cg16476235 chr8:21771668 DOK2 -0.37 -6.19 -0.32 1.82e-9 Lung cancer in ever smokers; CRC cis rs1799949 0.965 rs9646418 chr17:41425901 A/G cg25072359 chr17:41440525 NA 0.56 9.08 0.45 1.03e-17 Menopause (age at onset); CRC cis rs55702914 0.746 rs4850425 chr2:198152786 T/C cg10820045 chr2:198174542 NA -0.48 -9.0 -0.44 1.78e-17 Major depression and alcohol dependence; CRC cis rs2406342 1.000 rs2406342 chr18:74488280 G/T cg16472389 chr18:74514291 NA 0.37 5.69 0.3 2.78e-8 Adverse response to chemotherapy (neutropenia/leucopenia) (cisplatin); CRC cis rs28655083 0.956 rs35848061 chr16:77101327 A/G cg01753188 chr16:77233325 SYCE1L;MON1B -0.56 -7.77 -0.39 1.02e-13 Lobe attachment (rater-scored or self-reported); CRC cis rs4285028 0.851 rs1986368 chr3:121710969 A/T cg20356878 chr3:121714668 ILDR1 -0.5 -7.34 -0.37 1.72e-12 Multiple sclerosis; CRC cis rs1018836 0.923 rs10808615 chr8:91569704 A/T cg16814680 chr8:91681699 NA -0.74 -11.74 -0.54 8.38e-27 Ejection fraction in Tripanosoma cruzi seropositivity; CRC cis rs9903692 0.908 rs7222136 chr17:46199592 C/G cg21215337 chr17:46176117 CBX1 -0.43 -7.95 -0.4 3.09e-14 Pulse pressure; CRC cis rs7727544 0.836 rs10463892 chr5:131598705 T/C cg22638593 chr5:131593259 PDLIM4 0.35 6.88 0.35 2.97e-11 Blood metabolite levels; CRC cis rs4853012 0.941 rs78128123 chr2:74347525 C/T cg19729930 chr2:74357872 NA 0.78 11.38 0.53 1.56e-25 Gestational age at birth (maternal effect); CRC cis rs739496 0.542 rs12423926 chr12:111781055 C/T cg10833066 chr12:111807467 FAM109A -0.53 -6.97 -0.36 1.78e-11 Platelet count; CRC cis rs7647973 0.626 rs9824435 chr3:49674343 A/G cg13072238 chr3:49761600 GMPPB 0.56 6.02 0.31 4.71e-9 Menarche (age at onset); CRC cis rs9611565 0.512 rs2050031 chr22:42152266 A/G cg03806693 chr22:41940476 POLR3H 1.09 13.45 0.6 3.5e-33 Vitiligo; CRC cis rs875971 0.898 rs6977501 chr7:65693342 T/C cg00343986 chr7:65444356 GUSB -0.45 -6.53 -0.34 2.43e-10 Aortic root size; CRC cis rs2070488 0.775 rs6780349 chr3:38555178 C/T cg01465620 chr3:38496096 LOC100128640;ACVR2B -0.67 -11.09 -0.52 1.73e-24 Electrocardiographic conduction measures; CRC cis rs11229555 0.598 rs11229426 chr11:58180063 T/C cg15696309 chr11:58395628 NA -0.81 -10.31 -0.49 8.83e-22 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; CRC cis rs61612642 0.523 rs59004693 chr6:42157392 G/A cg10382835 chr6:42185730 MRPS10 0.68 7.29 0.37 2.33e-12 Eosinophil percentage of white cells;Sum eosinophil basophil counts;Eosinophil percentage of granulocytes;Eosinophil counts; CRC cis rs4237845 0.611 rs4760346 chr12:58334743 A/G cg02175503 chr12:58329896 NA 0.78 12.46 0.57 1.9e-29 Intelligence (multi-trait analysis); CRC cis rs13108904 0.837 rs4591539 chr4:1279938 G/C cg21620606 chr4:1342894 KIAA1530 0.36 5.89 0.31 9.62e-9 Obesity-related traits; CRC trans rs10077885 0.967 rs2974505 chr5:114431917 G/A cg08634079 chr15:65478037 CLPX -0.38 -6.09 -0.32 3.13e-9 Diastolic blood pressure;Systolic blood pressure; CRC cis rs896854 0.738 rs2515226 chr8:95965743 G/A cg13393036 chr8:95962371 TP53INP1 0.45 6.73 0.35 7.51e-11 Type 2 diabetes; CRC cis rs2944755 1.000 rs2944755 chr8:141574194 A/G cg07466463 chr8:141574207 EIF2C2 -0.4 -5.94 -0.31 7.18e-9 Thiazide-induced adverse metabolic effects in hypertensive patients; CRC trans rs11466653 1.000 rs11466643 chr4:38778241 G/A cg11403706 chr22:49042600 FAM19A5 0.62 6.11 0.32 2.76e-9 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs4889609 0.834 rs72785520 chr16:31070778 C/T cg00531865 chr16:30841666 NA -0.4 -5.64 -0.3 3.71e-8 Response to metformin (IC50); CRC cis rs5769707 0.904 rs7288869 chr22:50015327 C/T cg05373962 chr22:49881684 NA -0.39 -7.41 -0.38 1.06e-12 Monocyte count;Monocyte percentage of white cells; CRC cis rs4660261 0.526 rs2485997 chr1:44345841 G/C cg12908607 chr1:44402522 ARTN -0.46 -8.04 -0.41 1.66e-14 Intelligence (multi-trait analysis); CRC cis rs832540 0.603 rs6870175 chr5:56093371 A/G cg03609598 chr5:56110824 MAP3K1 -0.44 -5.91 -0.31 8.78e-9 Coronary artery disease; CRC cis rs3018066 0.666 rs7671145 chr4:107033675 C/T cg01869342 chr4:106983673 TBCK 0.44 5.73 0.3 2.29e-8 Cancer; CRC cis rs6762 0.748 rs5030780 chr11:838110 C/T cg03885332 chr11:832357 CD151 -0.42 -6.4 -0.33 5.25e-10 Mean platelet volume; CRC cis rs77861329 1.000 rs28659792 chr3:52107966 G/C cg08692210 chr3:52188851 WDR51A 0.84 7.14 0.37 5.98e-12 Macrophage inflammatory protein 1b levels; CRC cis rs4900538 0.963 rs4906205 chr14:102932447 A/G cg18135206 chr14:102964638 TECPR2 0.98 19.9 0.74 2.05e-58 Mean corpuscular volume;Mean corpuscular hemoglobin; CRC cis rs589448 0.902 rs315124 chr12:69771727 G/A cg14784868 chr12:69753453 YEATS4 0.9 17.43 0.69 1.19e-48 Cerebrospinal fluid biomarker levels; CRC cis rs75920871 0.588 rs3181 chr11:116907043 C/T cg01368799 chr11:117014884 PAFAH1B2 -0.43 -6.16 -0.32 2.09e-9 Subjective well-being; CRC cis rs2228479 0.850 rs62054599 chr16:89808850 C/G cg06656553 chr16:89960601 TCF25 -0.68 -5.71 -0.3 2.55e-8 Skin colour saturation; CRC cis rs9747201 0.962 rs62078313 chr17:80116708 A/C cg09264619 chr17:80180166 NA 0.49 7.02 0.36 1.26e-11 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs7662987 0.517 rs2602873 chr4:100039032 G/C cg12011299 chr4:100065546 ADH4 0.49 9.26 0.45 2.63e-18 Smoking initiation; CRC cis rs300703 0.542 rs443419 chr2:189800 C/T cg21211680 chr2:198530 NA -0.73 -9.09 -0.45 9.32e-18 Blood protein levels; CRC cis rs2629540 0.765 rs11245387 chr10:126537825 C/T cg08799069 chr10:126477246 METTL10 -0.5 -7.21 -0.37 3.93e-12 Cocaine dependence; CRC cis rs9847710 1.000 rs2564956 chr3:53070462 C/T cg04503182 chr3:53078218 SFMBT1 0.43 6.92 0.36 2.35e-11 Ulcerative colitis; CRC cis rs2239547 0.522 rs2336162 chr3:52951519 C/T cg11645453 chr3:52864694 ITIH4 -0.53 -9.51 -0.46 4.29e-19 Schizophrenia; CRC cis rs17376456 0.825 rs17372725 chr5:93135588 C/A cg09848695 chr5:92956644 FAM172A;MIR2277 0.63 5.8 0.3 1.56e-8 Diabetic retinopathy; CRC cis rs9522267 0.535 rs914036 chr13:112235542 G/A cg14352298 chr13:112236639 NA 0.29 6.74 0.35 7.32e-11 Hepatitis; CRC cis rs8141797 0.792 rs3752497 chr22:24581207 C/T cg20894457 chr22:24584366 SUSD2 0.64 7.39 0.38 1.26e-12 Amyotrophic lateral sclerosis;Coronary artery disease; CRC trans rs62103177 0.525 rs4799117 chr18:77756604 G/A cg05926928 chr17:57297772 GDPD1 -0.67 -7.71 -0.39 1.56e-13 Opioid sensitivity; CRC cis rs9303280 0.806 rs13380815 chr17:38027583 A/G cg17344932 chr17:38183730 MED24;SNORD124 0.36 5.67 0.3 3.13e-8 Self-reported allergy; CRC cis rs853679 0.550 rs1233707 chr6:28172953 G/A cg15845792 chr6:28175446 NA 1.01 15.4 0.65 1.16e-40 Depression; CRC cis rs6582630 0.513 rs11181246 chr12:38302670 C/T cg26384229 chr12:38710491 ALG10B 0.69 9.77 0.47 5.73e-20 Drug-induced liver injury (flucloxacillin); CRC trans rs951252 0.504 rs11734405 chr4:146081096 C/T cg22152050 chr18:60987904 BCL2 0.44 6.16 0.32 2.14e-9 Hip circumference; CRC cis rs116095464 0.510 rs73016876 chr5:244475 T/C cg22496380 chr5:211416 CCDC127 -0.91 -10.49 -0.5 2.17e-22 Breast cancer; CRC cis rs3741404 0.791 rs7112960 chr11:63907079 A/G cg19465662 chr11:63993652 NUDT22;TRPT1 0.85 13.85 0.61 1.09e-34 Platelet count; CRC cis rs10870270 0.956 rs7904594 chr10:133734671 C/T cg17892150 chr10:133769511 PPP2R2D -0.72 -10.94 -0.52 5.62e-24 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; CRC cis rs2408955 0.521 rs1476607 chr12:48524804 A/G cg00601486 chr12:48723148 H1FNT -0.36 -6.65 -0.34 1.23e-10 Glycated hemoglobin levels; CRC cis rs11098499 0.954 rs2389803 chr4:120393511 A/G cg09307838 chr4:120376055 NA -0.72 -11.01 -0.52 3.27e-24 Corneal astigmatism; CRC cis rs6964587 1.000 rs7802788 chr7:91736874 A/G cg17063962 chr7:91808500 NA 0.83 14.49 0.62 3.84e-37 Breast cancer; CRC cis rs72945132 0.882 rs113472486 chr11:70194945 C/G cg00319359 chr11:70116639 PPFIA1 0.56 6.1 0.32 2.93e-9 Coronary artery disease; CRC cis rs9322193 0.923 rs10872649 chr6:150080590 T/G cg13206674 chr6:150067644 NUP43 0.68 10.28 0.49 1.08e-21 Lung cancer; CRC cis rs782590 0.721 rs782641 chr2:55929294 C/T cg18811423 chr2:55921094 PNPT1 0.82 14.71 0.63 5.17e-38 Metabolic syndrome; CRC cis rs990171 1.000 rs2110735 chr2:103050925 A/G cg03938978 chr2:103052716 IL18RAP 0.45 5.8 0.3 1.53e-8 Lymphocyte counts; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg04266864 chr17:27224823 FLOT2;DHRS13 0.43 6.42 0.33 4.79e-10 Intelligence (multi-trait analysis); CRC cis rs28493229 0.522 rs17713068 chr19:41270055 A/C cg21869046 chr19:41225005 ITPKC 0.56 7.96 0.4 2.88e-14 Kawasaki disease; CRC cis rs7191439 0.722 rs6500491 chr16:88783521 T/C cg27087555 chr16:88793112 FAM38A -1.39 -13.18 -0.59 3.89e-32 Plateletcrit; CRC cis rs12762955 0.561 rs7076107 chr10:1043647 T/C cg26597838 chr10:835615 NA -0.45 -6.1 -0.32 2.92e-9 Response to angiotensin II receptor blocker therapy; CRC cis rs4332037 0.615 rs62435134 chr7:1895463 T/G cg23422044 chr7:1970798 MAD1L1 -0.54 -6.73 -0.35 7.37e-11 Bipolar disorder; CRC cis rs780096 0.546 rs1647284 chr2:27608115 C/T cg17158414 chr2:27665306 KRTCAP3 -0.28 -6.01 -0.31 5.01e-9 Total body bone mineral density; CRC cis rs116095464 0.558 rs73029475 chr5:206969 T/C cg22857025 chr5:266934 NA -1.14 -11.87 -0.55 2.78e-27 Breast cancer; CRC trans rs4332037 0.510 rs11762803 chr7:1886805 A/G cg11693508 chr17:37793320 STARD3 0.55 7.76 0.39 1.06e-13 Bipolar disorder; CRC cis rs459571 0.839 rs2519831 chr9:136886257 T/A cg13789015 chr9:136890014 NCRNA00094 0.43 5.67 0.3 3.16e-8 Platelet distribution width; CRC cis rs6142102 0.961 rs2284389 chr20:32656841 C/G cg08999081 chr20:33150536 PIGU 0.38 5.95 0.31 6.75e-9 Skin pigmentation; CRC cis rs3741404 0.825 rs11604782 chr11:63946650 G/A cg19465662 chr11:63993652 NUDT22;TRPT1 0.88 14.44 0.62 5.83e-37 Platelet count; CRC cis rs2075371 0.611 rs34573600 chr7:134018937 C/T cg20476274 chr7:133979776 SLC35B4 0.53 7.63 0.39 2.49e-13 Mean platelet volume; CRC cis rs9311474 0.508 rs11720159 chr3:52617802 T/G cg08222913 chr3:52553049 STAB1 -0.33 -6.28 -0.33 1.08e-9 Electroencephalogram traits; CRC cis rs9914988 0.943 rs9913801 chr17:27132105 G/A cg07195577 chr17:27052828 TLCD1 0.42 6.02 0.32 4.64e-9 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs7618915 0.621 rs6788993 chr3:52605136 T/C cg18404041 chr3:52824283 ITIH1 -0.43 -8.99 -0.44 1.95e-17 Bipolar disorder; CRC cis rs801193 0.660 rs4610622 chr7:66224497 T/C cg11764359 chr7:65958608 NA 0.6 9.31 0.46 1.86e-18 Aortic root size; CRC cis rs12134245 0.776 rs61548854 chr1:92001536 C/T cg07090678 chr1:91966139 CDC7 0.42 6.95 0.36 1.93e-11 Breast cancer; CRC cis rs72720396 1.000 rs72720396 chr1:91191582 A/G cg13456504 chr1:91191583 NA 0.61 7.38 0.38 1.29e-12 Morning vs. evening chronotype;Chronotype; CRC trans rs11098499 0.618 rs28491261 chr4:120294900 C/A cg25214090 chr10:38739885 LOC399744 0.63 9.77 0.47 5.88e-20 Corneal astigmatism; CRC cis rs73206853 0.841 rs55634798 chr12:110833748 G/T cg12870014 chr12:110450643 ANKRD13A 0.78 8.4 0.42 1.35e-15 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC cis rs17253792 0.822 rs10151664 chr14:56029533 A/G cg01858014 chr14:56050164 KTN1 -0.8 -7.36 -0.38 1.5e-12 Putamen volume; CRC cis rs9303401 0.614 rs34920953 chr17:56589406 G/A cg02118635 chr17:56770003 RAD51C;TEX14 0.79 9.72 0.47 8.75e-20 Cognitive test performance; CRC cis rs3806843 0.966 rs6579965 chr5:140168811 T/G cg19875535 chr5:140030758 IK 0.6 9.78 0.47 5.3e-20 Depressive symptoms (multi-trait analysis); CRC cis rs172166 0.516 rs1150670 chr6:28130559 A/G cg02683197 chr6:28174875 NA 0.47 6.68 0.35 1.04e-10 Cardiac Troponin-T levels; CRC cis rs875971 0.862 rs7798630 chr7:65771479 G/C cg18252515 chr7:66147081 NA 0.41 5.73 0.3 2.26e-8 Aortic root size; CRC cis rs4253772 0.637 rs6008357 chr22:46652104 T/G cg03482458 chr22:46692211 CN5H6.4;GTSE1 0.47 6.26 0.33 1.17e-9 LDL cholesterol;Cholesterol, total; CRC cis rs2270875 1.000 rs10435560 chr8:132937397 G/A cg24184792 chr8:132919238 EFR3A -0.67 -6.7 -0.35 9.08e-11 Response to cholinesterase inhibitors in Alzheimer's disease; CRC cis rs7618915 0.501 rs767418 chr3:52767427 C/T cg18404041 chr3:52824283 ITIH1 -0.41 -8.4 -0.42 1.36e-15 Bipolar disorder; CRC cis rs9322193 0.809 rs9479808 chr6:150072464 A/T cg13206674 chr6:150067644 NUP43 0.67 10.01 0.48 9.15e-21 Lung cancer; CRC trans rs1814175 0.645 rs1721996 chr11:49915527 G/A cg03929089 chr4:120376271 NA -0.91 -16.07 -0.66 2.65e-43 Height; CRC cis rs1129187 0.755 rs7760250 chr6:42929839 G/A cg00597713 chr6:42947103 PEX6 -0.4 -5.68 -0.3 3.04e-8 Alzheimer's disease in APOE e4+ carriers; CRC cis rs2282802 0.685 rs2436391 chr5:139557385 C/T cg26211634 chr5:139558579 C5orf32 -0.44 -7.73 -0.39 1.32e-13 Intelligence (multi-trait analysis); CRC cis rs12701220 0.895 rs12534778 chr7:1065861 C/T cg26240231 chr7:1148101 C7orf50 0.46 6.16 0.32 2.08e-9 Bronchopulmonary dysplasia; CRC cis rs62007496 0.520 rs8008679 chr14:103605707 T/C cg09274347 chr14:103599552 TNFAIP2 0.51 5.83 0.31 1.33e-8 Language performance in older adults (adjusted for episodic memory); CRC cis rs7091068 0.550 rs7079013 chr10:95487878 A/C cg20715218 chr10:95462985 C10orf4 0.49 6.66 0.34 1.14e-10 Urinary tract infection frequency; CRC cis rs561341 0.943 rs508566 chr17:30289861 G/C cg00745463 chr17:30367425 LRRC37B -0.88 -9.72 -0.47 8.52e-20 Hip circumference adjusted for BMI; CRC cis rs7959452 0.640 rs4761154 chr12:69705362 A/G cg14784868 chr12:69753453 YEATS4 -0.76 -12.22 -0.56 1.46e-28 Blood protein levels; CRC cis rs35110281 0.782 rs6518302 chr21:45018478 A/G cg04455712 chr21:45112962 RRP1B 0.41 7.97 0.4 2.57e-14 Mean corpuscular volume; CRC cis rs11098499 0.754 rs11098502 chr4:120252063 T/A cg24375607 chr4:120327624 NA 0.47 7.6 0.39 3.06e-13 Corneal astigmatism; CRC cis rs2997447 0.633 rs6665062 chr1:26362001 C/T cg19633962 chr1:26362018 EXTL1 -0.63 -6.34 -0.33 7.42e-10 QRS complex (12-leadsum); CRC cis rs9322193 0.847 rs12210605 chr6:150138403 A/G cg04369109 chr6:150039330 LATS1 -0.45 -5.78 -0.3 1.72e-8 Lung cancer; CRC cis rs2243480 1.000 rs73150014 chr7:65450919 A/C cg12463550 chr7:65579703 CRCP 0.66 6.25 0.33 1.27e-9 Diabetic kidney disease; CRC trans rs6472235 0.837 rs7017618 chr8:66930392 A/C cg07884673 chr3:53033167 SFMBT1 -0.45 -6.03 -0.32 4.47e-9 Myopia (pathological);Plateletcrit; CRC cis rs7618915 0.571 rs6798246 chr3:52599922 G/A cg10802521 chr3:52805072 NEK4 -0.58 -9.01 -0.44 1.68e-17 Bipolar disorder; CRC cis rs4728302 0.643 rs2346440 chr7:133685512 G/C cg03336402 chr7:133662267 EXOC4 -0.45 -6.95 -0.36 1.93e-11 Intelligence;Intelligence (multi-trait analysis); CRC cis rs6838801 0.857 rs17002148 chr4:77580240 A/G cg17476223 chr4:77663285 SHROOM3 -0.41 -5.7 -0.3 2.63e-8 Cleft lip with or without cleft palate; CRC cis rs798554 1.000 rs798544 chr7:2763102 A/G cg17321639 chr7:2759063 NA 0.54 7.59 0.39 3.25e-13 Height; CRC cis rs1348850 0.750 rs55792594 chr2:178496468 C/T cg02961200 chr2:178257176 LOC100130691;AGPS 0.52 7.38 0.38 1.27e-12 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC trans rs2303319 0.504 rs56009150 chr2:162598582 T/C cg18122310 chr12:50236657 BCDIN3D -0.73 -6.29 -0.33 1.02e-9 Cognitive function; CRC cis rs45509595 0.841 rs2747054 chr6:27783359 A/G cg03623178 chr6:28175578 NA 0.78 6.64 0.34 1.27e-10 Breast cancer; CRC cis rs10504229 0.683 rs11785258 chr8:58132893 A/G cg24829409 chr8:58192753 C8orf71 -0.55 -8.03 -0.4 1.71e-14 Developmental language disorder (linguistic errors); CRC cis rs12216125 0.801 rs56107510 chr6:25987436 C/A cg16482183 chr6:26056742 HIST1H1C 0.61 8.37 0.42 1.7e-15 Iron status biomarkers; CRC cis rs1728785 1.000 rs1645923 chr16:68581051 G/A cg02972257 chr16:68554789 NA -0.58 -7.24 -0.37 3.21e-12 Ulcerative colitis; CRC cis rs77861329 0.920 rs9846049 chr3:52120214 A/G cg08692210 chr3:52188851 WDR51A 0.85 8.07 0.41 1.31e-14 Macrophage inflammatory protein 1b levels; CRC cis rs1005277 0.579 rs176838 chr10:38371899 A/T cg17219203 chr10:38645113 HSD17B7P2 0.4 5.61 0.3 4.31e-8 Extrinsic epigenetic age acceleration; CRC trans rs12599106 0.648 rs12447240 chr16:34928236 C/T cg18110333 chr6:292329 DUSP22 0.69 10.17 0.49 2.72e-21 Menopause (age at onset); CRC cis rs17253792 0.822 rs79807559 chr14:56108117 G/A cg24579896 chr14:56047964 C14orf33;KTN1 0.71 5.64 0.3 3.63e-8 Putamen volume; CRC cis rs4481887 0.927 rs4558008 chr1:248477641 C/T cg13385794 chr1:248469461 NA 0.4 7.09 0.36 8.35e-12 Common traits (Other); CRC trans rs11343 0.675 rs7359333 chr16:19262344 A/T cg16355271 chr7:27283528 EVX1 -0.4 -5.96 -0.31 6.37e-9 Parkinson's disease; CRC cis rs3796352 1.000 rs35720014 chr3:52982110 A/C cg27565382 chr3:53032988 SFMBT1 0.78 6.24 0.33 1.33e-9 Immune reponse to smallpox (secreted IL-2); CRC cis rs6951245 0.554 rs79367977 chr7:1152657 G/A cg21664854 chr7:1097933 C7orf50;GPR146 0.57 7.17 0.37 5.06e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs875971 0.825 rs10281499 chr7:66048966 A/G cg00343986 chr7:65444356 GUSB -0.45 -6.3 -0.33 9.71e-10 Aortic root size; CRC cis rs1448094 0.512 rs1584368 chr12:86245117 A/C cg18827107 chr12:86230957 RASSF9 -0.45 -7.38 -0.38 1.32e-12 Major depressive disorder; CRC trans rs10838798 0.607 rs11039537 chr11:48154603 A/G cg15704280 chr7:45808275 SEPT13 -0.45 -6.09 -0.32 3.1e-9 Height; CRC cis rs7119 0.717 rs12902852 chr15:77809016 C/G cg10437265 chr15:77819839 NA 0.68 12.43 0.57 2.41e-29 Type 2 diabetes; CRC trans rs7395662 0.617 rs1976509 chr11:48964603 C/T cg21153622 chr11:89784906 NA 0.46 7.28 0.37 2.48e-12 HDL cholesterol; CRC cis rs796364 1.000 rs1704186 chr2:200769539 A/C cg25936922 chr2:200820526 C2orf60;C2orf47 0.72 8.01 0.4 2.03e-14 Schizophrenia; CRC cis rs9814567 0.964 rs6772406 chr3:134210183 A/G cg06541857 chr3:134203789 ANAPC13;CEP63 -0.41 -6.19 -0.32 1.74e-9 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs9311474 0.508 rs17052259 chr3:52593138 A/G cg18099408 chr3:52552593 STAB1 -0.48 -8.31 -0.42 2.48e-15 Electroencephalogram traits; CRC cis rs72945132 0.882 rs12294540 chr11:70118973 A/T cg00319359 chr11:70116639 PPFIA1 0.68 7.5 0.38 6.05e-13 Coronary artery disease; CRC cis rs7618915 0.547 rs13085895 chr3:52678270 G/C cg15147215 chr3:52552868 STAB1 -0.62 -10.24 -0.49 1.48e-21 Bipolar disorder; CRC cis rs4731207 0.698 rs10260227 chr7:124446486 T/C cg23710748 chr7:124431027 NA 0.37 5.96 0.31 6.53e-9 Cutaneous malignant melanoma; CRC trans rs208520 0.690 rs1100981 chr6:66852052 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.05 -14.78 -0.63 3.02e-38 Exhaled nitric oxide output; CRC cis rs7937682 0.960 rs480293 chr11:111469132 A/C cg19812747 chr11:111475976 SIK2 -0.57 -9.72 -0.47 8.51e-20 Primary sclerosing cholangitis; CRC trans rs459571 0.920 rs2520094 chr9:136919985 A/T cg09836344 chr4:1243392 C4orf42;CTBP1 -0.81 -11.68 -0.54 1.33e-26 Platelet distribution width; CRC trans rs7613875 0.620 rs17657664 chr3:50032008 T/G cg21659725 chr3:3221576 CRBN 0.44 6.43 0.33 4.45e-10 Body mass index; CRC cis rs58688157 0.705 rs12419694 chr11:598033 C/T cg03909863 chr11:638404 DRD4 -0.52 -7.13 -0.37 6.36e-12 Systemic lupus erythematosus; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg11361691 chr3:57993876 FLNB -0.4 -6.34 -0.33 7.66e-10 Myopia (pathological); CRC cis rs35493131 0.557 rs7251466 chr19:42576952 C/G cg22273452 chr19:42578905 ZNF574 0.56 5.64 0.3 3.58e-8 Monocyte count; CRC trans rs6951245 0.554 rs10270249 chr7:1151886 G/T cg13565492 chr6:43139072 SRF -0.83 -10.53 -0.5 1.5e-22 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs1395 0.778 rs4665960 chr2:27467598 C/T cg14242246 chr2:27434262 C2orf28;SLC5A6 0.43 7.77 0.39 9.85e-14 Blood metabolite levels; CRC cis rs1799949 1.000 rs1545764 chr17:41424565 G/A cg19454999 chr17:41278357 BRCA1;NBR2 0.52 7.88 0.4 4.82e-14 Menopause (age at onset); CRC cis rs4478858 0.735 rs10914344 chr1:31769025 T/C cg00250761 chr1:31883323 NA -0.43 -8.2 -0.41 5.39e-15 Alcohol dependence; CRC cis rs629535 0.814 rs674429 chr8:70069942 G/A cg26132723 chr8:70041827 NA 0.35 5.77 0.3 1.8e-8 Dupuytren's disease; CRC cis rs897984 0.609 rs12445650 chr16:31044897 G/A cg02466173 chr16:30829666 NA -0.61 -9.13 -0.45 6.96e-18 Dementia with Lewy bodies; CRC cis rs13256369 0.802 rs1060106 chr8:8561452 A/G cg18904891 chr8:8559673 CLDN23 0.52 6.91 0.36 2.51e-11 Obesity-related traits; CRC trans rs8002861 0.875 rs12867890 chr13:44423088 A/G cg12856521 chr11:46389249 DGKZ -0.43 -6.72 -0.35 7.85e-11 Leprosy; CRC trans rs1005277 0.579 rs1780139 chr10:38503018 C/T cg27523141 chr10:43048294 ZNF37B 0.47 6.89 0.36 2.87e-11 Extrinsic epigenetic age acceleration; CRC trans rs2303319 0.504 rs55925603 chr2:162497210 G/A cg13490827 chr1:46269305 MAST2 -0.7 -6.28 -0.33 1.09e-9 Cognitive function; CRC cis rs1448094 0.933 rs10779218 chr12:86320053 A/G cg18827107 chr12:86230957 RASSF9 -0.36 -5.98 -0.31 5.85e-9 Major depressive disorder; CRC cis rs853679 0.517 rs56310871 chr6:28044482 A/G cg03623178 chr6:28175578 NA 0.93 12.26 0.56 9.88e-29 Depression; CRC cis rs17331151 0.505 rs79979130 chr3:52551010 C/T cg07884673 chr3:53033167 SFMBT1 0.87 6.46 0.34 3.82e-10 Immune reponse to smallpox (secreted IL-2); CRC cis rs3736594 0.546 rs965813 chr2:27789861 T/A cg27432699 chr2:27873401 GPN1 0.64 8.48 0.42 7.75e-16 Fasting blood glucose;Fasting blood glucose (BMI interaction); CRC cis rs11190604 1.000 rs11190599 chr10:102295420 C/T cg16342193 chr10:102329863 NA -0.36 -5.99 -0.31 5.62e-9 Palmitoleic acid (16:1n-7) levels; CRC cis rs6951245 0.580 rs77101766 chr7:1122438 A/G cg04025307 chr7:1156635 C7orf50 0.72 9.03 0.45 1.52e-17 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC trans rs2832077 0.943 rs2832097 chr21:30173340 A/T cg14791747 chr16:20752902 THUMPD1 -0.56 -7.6 -0.39 3.17e-13 Cognitive test performance; CRC cis rs9807989 0.765 rs13424006 chr2:102967236 T/C cg03938978 chr2:103052716 IL18RAP 0.37 5.97 0.31 6.2e-9 Asthma; CRC cis rs4819052 0.885 rs28576202 chr21:46674684 G/A cg11663144 chr21:46675770 NA -0.86 -14.97 -0.64 5.18e-39 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs317689 0.690 rs604168 chr12:69671158 C/T cg20891283 chr12:69753455 YEATS4 0.45 5.89 0.31 9.42e-9 Response to diuretic therapy; CRC cis rs11122272 0.735 rs2790885 chr1:231529925 C/T cg06096015 chr1:231504339 EGLN1 0.41 6.18 0.32 1.91e-9 Hemoglobin concentration; CRC cis rs2645694 0.532 rs2645706 chr4:77829606 A/C cg03477792 chr4:77819574 ANKRD56 0.43 6.22 0.32 1.49e-9 Emphysema distribution in smoking; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg14310890 chr6:108881016 FOXO3 0.54 6.96 0.36 1.84e-11 Thyroid stimulating hormone; CRC cis rs9487051 0.714 rs1546722 chr6:109625797 A/G cg12927641 chr6:109611667 NA -0.36 -6.4 -0.33 5.28e-10 Reticulocyte fraction of red cells; CRC cis rs910316 0.726 rs175040 chr14:75469555 A/G cg03030879 chr14:75389066 RPS6KL1 0.38 5.66 0.3 3.28e-8 Height; CRC trans rs2303319 0.504 rs62188984 chr2:162514518 G/A cg12500891 chr11:57225987 NA -0.67 -6.03 -0.32 4.51e-9 Cognitive function; CRC cis rs832540 0.931 rs331499 chr5:56210923 C/T cg12311346 chr5:56204834 C5orf35 -0.49 -7.44 -0.38 8.94e-13 Coronary artery disease; CRC cis rs9787249 0.957 rs6670841 chr1:40220284 C/G cg24920358 chr1:40204285 PPIE 0.58 8.91 0.44 3.49e-17 Blood protein levels; CRC cis rs9911578 0.967 rs8075786 chr17:56819216 T/C cg05425664 chr17:57184151 TRIM37 -0.48 -7.6 -0.39 3.02e-13 Intelligence (multi-trait analysis); CRC trans rs561341 0.883 rs2074102 chr17:30228884 G/A cg27661571 chr11:113659931 NA -0.67 -7.54 -0.38 4.55e-13 Hip circumference adjusted for BMI; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg08744769 chr2:70142523 MXD1 0.44 6.19 0.32 1.8e-9 Response to antipsychotic treatment; CRC cis rs34172651 0.876 rs7186893 chr16:24806420 G/T cg06028605 chr16:24865363 SLC5A11 0.44 8.07 0.41 1.33e-14 Intelligence (multi-trait analysis); CRC cis rs75059851 1.000 rs75059851 chr11:133822569 A/G cg17703048 chr11:133852993 NA -0.45 -5.82 -0.31 1.38e-8 Schizophrenia; CRC cis rs9381040 0.701 rs6933231 chr6:41163700 T/C cg03644281 chr6:41068752 NFYA;LOC221442 -0.43 -6.36 -0.33 6.79e-10 Alzheimer's disease (late onset); CRC cis rs3820068 0.603 rs59475085 chr1:15911131 G/A cg27534772 chr1:16042836 PLEKHM2 0.5 8.98 0.44 2.12e-17 Systolic blood pressure; CRC cis rs909674 0.818 rs5757681 chr22:39845547 A/G cg05872129 chr22:39784769 NA -0.45 -7.88 -0.4 4.89e-14 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; CRC cis rs7586879 0.828 rs11685125 chr2:25092104 A/G cg04586622 chr2:25135609 ADCY3 -0.55 -9.36 -0.46 1.32e-18 Body mass index; CRC cis rs77633900 0.614 rs12442966 chr15:76918290 G/T cg21673338 chr15:77095150 SCAPER 0.64 6.97 0.36 1.79e-11 Non-glioblastoma glioma;Glioma; CRC cis rs9488822 0.636 rs11153592 chr6:116330574 T/C cg05304507 chr6:116381966 FRK 0.3 8.24 0.41 4.03e-15 Cholesterol, total;LDL cholesterol; CRC cis rs7819412 0.654 rs34741518 chr8:10776860 A/C cg27411982 chr8:10470053 RP1L1 -0.42 -6.5 -0.34 2.98e-10 Triglycerides; CRC cis rs7208859 0.573 rs73267829 chr17:29003939 G/A cg13385521 chr17:29058706 SUZ12P 0.65 7.06 0.36 9.81e-12 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs6089584 0.586 rs1079755 chr20:60615262 G/A cg23262073 chr20:60523788 NA -0.37 -5.87 -0.31 1.05e-8 Body mass index; CRC cis rs6088590 0.610 rs6120663 chr20:33081906 A/C cg08999081 chr20:33150536 PIGU -0.58 -9.95 -0.48 1.4e-20 Coronary artery disease; CRC cis rs9807989 0.839 rs4988958 chr2:102968285 T/C cg03938978 chr2:103052716 IL18RAP 0.37 5.97 0.31 6.2e-9 Asthma; CRC cis rs2364543 0.624 rs61774752 chr1:41847024 T/C cg08462924 chr1:41848221 NA 0.43 6.66 0.34 1.14e-10 Intelligence (multi-trait analysis); CRC cis rs75920871 0.528 rs11216240 chr11:116899248 A/T cg01368799 chr11:117014884 PAFAH1B2 -0.41 -5.84 -0.31 1.26e-8 Subjective well-being; CRC cis rs7666738 0.830 rs13118945 chr4:98968586 T/G cg17366294 chr4:99064904 C4orf37 0.42 7.21 0.37 3.76e-12 Colonoscopy-negative controls vs population controls; CRC cis rs4604732 0.631 rs75600450 chr1:247625492 C/T cg12758973 chr1:247694275 LOC148824;OR2C3 0.42 6.17 0.32 2.03e-9 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CRC trans rs1814175 0.817 rs28594987 chr11:50045181 C/T cg03929089 chr4:120376271 NA -0.93 -17.98 -0.7 7.84e-51 Height; CRC cis rs2075371 1.000 rs2544213 chr7:133982867 G/C cg02659138 chr7:134003124 SLC35B4 0.38 6.51 0.34 2.73e-10 Mean platelet volume; CRC cis rs780096 0.546 rs12473776 chr2:27636474 A/G cg12648201 chr2:27665141 KRTCAP3 -0.29 -5.83 -0.31 1.3e-8 Total body bone mineral density; CRC cis rs875971 0.830 rs427973 chr7:65526648 C/A cg18876405 chr7:65276391 NA 0.52 8.83 0.44 6.38e-17 Aortic root size; CRC cis rs3733585 0.725 rs10939636 chr4:9972640 T/G cg00071950 chr4:10020882 SLC2A9 -0.55 -9.77 -0.47 5.9e-20 Cleft plate (environmental tobacco smoke interaction); CRC cis rs344364 0.511 rs1742460 chr16:1945441 G/C cg09830162 chr16:1889614 FAHD1;C16orf73 -0.82 -9.5 -0.46 4.38e-19 Glomerular filtration rate in chronic kidney disease; CRC trans rs7937682 0.889 rs567859 chr11:111486738 A/G cg18187862 chr3:45730750 SACM1L 0.45 6.55 0.34 2.23e-10 Primary sclerosing cholangitis; CRC cis rs2243480 1.000 rs1701750 chr7:65467145 T/C cg18252515 chr7:66147081 NA -1.06 -12.27 -0.56 9.34e-29 Diabetic kidney disease; CRC cis rs7811142 0.830 rs1063945 chr7:99930447 C/T cg00814883 chr7:100076585 TSC22D4 -0.68 -8.38 -0.42 1.53e-15 Platelet count; CRC cis rs3126085 0.935 rs12144058 chr1:152170216 C/T cg09127314 chr1:152161683 NA 0.49 6.25 0.33 1.26e-9 Atopic dermatitis; CRC cis rs10504229 1.000 rs73609747 chr8:58189104 G/C cg05313129 chr8:58192883 C8orf71 -0.47 -6.99 -0.36 1.49e-11 Developmental language disorder (linguistic errors); CRC cis rs6951245 0.529 rs10262070 chr7:1141738 C/T cg18297960 chr7:1142765 C7orf50 -0.43 -5.91 -0.31 8.66e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs1552244 1.000 rs6793396 chr3:10110927 T/C cg00166722 chr3:10149974 C3orf24 0.7 9.53 0.46 3.69e-19 Alzheimer's disease; CRC trans rs2727020 0.576 rs11040223 chr11:49034633 G/T cg03929089 chr4:120376271 NA -0.49 -6.99 -0.36 1.55e-11 Coronary artery disease; CRC cis rs7552404 1.000 rs4949674 chr1:76213715 C/A cg10523679 chr1:76189770 ACADM 0.85 11.71 0.54 9.97e-27 Blood metabolite levels;Acylcarnitine levels; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg23616842 chr20:4129483 SMOX 0.38 6.14 0.32 2.37e-9 Liver disease severity in Alagille syndrome; CRC cis rs2153535 0.580 rs6927589 chr6:8456632 A/G cg21535247 chr6:8435926 SLC35B3 -0.51 -7.91 -0.4 3.87e-14 Motion sickness; CRC cis rs11719291 0.833 rs11715835 chr3:48770732 C/T cg00383909 chr3:49044727 WDR6 1.23 11.76 0.54 6.79e-27 Cognitive function; CRC trans rs10242455 0.702 rs73711280 chr7:99039604 C/T cg09045935 chr12:6379348 NA 1.13 9.23 0.45 3.42e-18 Blood metabolite levels; CRC cis rs13191362 1.000 rs67094146 chr6:163145412 G/C cg06582575 chr6:163149167 PACRG;PARK2 0.82 11.48 0.53 6.79e-26 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs7927771 0.832 rs67116452 chr11:47385194 G/A cg20307385 chr11:47447363 PSMC3 -0.63 -9.23 -0.45 3.47e-18 Subjective well-being; CRC cis rs929354 0.742 rs10274687 chr7:156933181 T/G cg16102536 chr7:156981717 UBE3C 0.4 6.69 0.35 9.57e-11 Body mass index; CRC cis rs4965359 0.808 rs1598492 chr15:101577534 A/G cg01350081 chr15:101592003 LRRK1 0.37 6.27 0.33 1.14e-9 Central corneal thickness; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg01720705 chr1:231175557 FAM89A 0.41 6.52 0.34 2.6e-10 Liver disease severity in Alagille syndrome; CRC cis rs6685188 0.920 rs6593964 chr1:205662337 G/T cg14893161 chr1:205819251 PM20D1 0.42 5.86 0.31 1.13e-8 White blood cell count (basophil);Basophil percentage of white cells; CRC cis rs2072510 0.593 rs2540498 chr12:96400569 T/A cg09636302 chr12:96389483 HAL -0.5 -6.42 -0.33 4.89e-10 Metabolite levels (small molecules and protein measures); CRC cis rs7927592 0.956 rs11228278 chr11:68308530 G/A cg01657329 chr11:68192670 LRP5 -0.5 -7.66 -0.39 2.13e-13 Total body bone mineral density; CRC cis rs1062746 0.528 rs12149622 chr16:87340235 A/G cg02258303 chr16:87377426 FBXO31 -0.51 -7.33 -0.37 1.75e-12 Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 2 peripheral neuropathy); CRC cis rs9394438 0.593 rs10947679 chr6:37543524 C/G cg00985040 chr6:37553208 NA 0.39 6.6 0.34 1.63e-10 IgG glycosylation; CRC cis rs4665809 0.590 rs7582341 chr2:26416301 A/G cg26119090 chr2:26468346 HADHA;HADHB -1.05 -15.29 -0.64 3.04e-40 Gut microbiome composition (summer); CRC cis rs6951245 0.938 rs112425403 chr7:1071531 A/G cg24642844 chr7:1081250 C7orf50 -0.78 -9.29 -0.46 2.15e-18 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs1003719 0.679 rs2835674 chr21:38581522 T/A cg10648535 chr21:38446584 PIGP;TTC3 -0.46 -6.42 -0.33 4.66e-10 Eye color traits; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg13713052 chr3:122102218 FAM162A;CCDC58 0.52 6.87 0.35 3.23e-11 Thyroid stimulating hormone; CRC cis rs1799949 0.965 rs33988650 chr17:41287880 A/G cg01879757 chr17:41196368 BRCA1 -0.44 -6.67 -0.35 1.06e-10 Menopause (age at onset); CRC cis rs684232 0.602 rs379998 chr17:556884 A/G cg15660573 chr17:549704 VPS53 -0.87 -15.78 -0.66 3.72e-42 Prostate cancer; CRC cis rs738322 0.555 rs731821 chr22:38559448 C/A cg25457927 chr22:38595422 NA -0.37 -7.67 -0.39 1.91e-13 Cutaneous nevi; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg02569759 chr3:10052551 LOC401052 0.49 7.74 0.39 1.26e-13 Liver disease severity in Alagille syndrome; CRC cis rs12541335 0.639 rs35068739 chr8:22201719 T/C cg02788857 chr8:22132959 PIWIL2 0.51 8.61 0.43 3.12e-16 Hypertriglyceridemia; CRC cis rs7618915 0.571 rs6762457 chr3:52609157 G/A cg05573699 chr3:52720067 GNL3;PBRM1 -0.46 -6.58 -0.34 1.81e-10 Bipolar disorder; CRC cis rs35306767 0.715 rs12777801 chr10:1036285 T/A cg20503657 chr10:835505 NA 0.93 10.53 0.5 1.51e-22 Eosinophil percentage of granulocytes; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg23388714 chr18:51750950 MBD2 0.38 5.99 0.31 5.44e-9 Liver disease severity in Alagille syndrome; CRC trans rs6463739 0.965 rs7795244 chr7:7902588 T/C cg09417038 chr21:47716443 C21orf57 0.4 6.09 0.32 3.12e-9 Small cell lung carcinoma; CRC cis rs8070740 0.838 rs1050390 chr17:5336058 G/A cg25236894 chr17:5323110 RPAIN;NUP88 0.44 5.85 0.31 1.2e-8 Menopause (age at onset); CRC cis rs1129187 0.755 rs9471986 chr6:42944127 A/G cg02353165 chr6:42928485 GNMT 0.72 12.13 0.56 3.18e-28 Alzheimer's disease in APOE e4+ carriers; CRC cis rs2404602 0.583 rs12908334 chr15:76581592 C/T cg26408565 chr15:76604113 ETFA -0.36 -5.79 -0.3 1.65e-8 Blood metabolite levels; CRC cis rs13118159 0.742 rs7679860 chr4:1333987 C/T cg19318889 chr4:1322082 MAEA 0.48 6.89 0.36 2.87e-11 Longevity; CRC trans rs9291683 0.610 rs993172 chr4:10324361 G/T cg26043149 chr18:55253948 FECH 0.53 7.84 0.4 6.27e-14 Bone mineral density; CRC cis rs644799 0.965 rs499076 chr11:95546341 A/G cg25622487 chr11:95524042 FAM76B;CEP57 0.76 11.87 0.55 2.62e-27 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs2836950 0.527 rs2836948 chr21:40599677 T/C cg11890956 chr21:40555474 PSMG1 -0.68 -10.21 -0.49 1.93e-21 Menarche (age at onset); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg24158363 chr17:73401717 GRB2 0.37 6.43 0.33 4.43e-10 Liver disease severity in Alagille syndrome; CRC cis rs4819052 0.959 rs9976074 chr21:46655638 G/T cg11663144 chr21:46675770 NA -0.74 -9.91 -0.48 1.95e-20 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs881375 0.715 rs10985073 chr9:123643855 T/C cg09586646 chr9:123605570 PSMD5;LOC253039 0.46 6.76 0.35 6.27e-11 Rheumatoid arthritis; CRC cis rs6570726 0.791 rs6570693 chr6:145910841 C/T cg23711669 chr6:146136114 FBXO30 0.68 11.28 0.53 3.51e-25 Lobe attachment (rater-scored or self-reported); CRC trans rs2235573 0.625 rs10427673 chr22:38427551 G/C cg19894588 chr14:64061835 NA 0.42 6.26 0.33 1.22e-9 Glioblastoma;Glioma; CRC cis rs12142240 0.698 rs17361887 chr1:46834775 A/G cg00530320 chr1:46809349 NSUN4 0.57 7.69 0.39 1.76e-13 Menopause (age at onset); CRC cis rs9549367 0.789 rs9577220 chr13:113908294 T/A cg00898013 chr13:113819073 PROZ -0.45 -6.45 -0.33 4.06e-10 Platelet distribution width; CRC cis rs7618501 0.966 rs2352974 chr3:49890613 C/T cg24308560 chr3:49941425 MST1R -0.45 -7.21 -0.37 3.87e-12 Intelligence (multi-trait analysis); CRC trans rs6561151 0.681 rs7995955 chr13:44434836 C/G cg17145862 chr1:211918768 LPGAT1 0.49 6.4 0.33 5.47e-10 Crohn's disease; CRC cis rs4073416 0.542 rs3825639 chr14:66028505 T/C cg03016385 chr14:66212404 NA -0.44 -6.12 -0.32 2.62e-9 N-glycan levels; CRC trans rs916888 0.821 rs199506 chr17:44859031 A/G cg22968622 chr17:43663579 NA -1.22 -16.01 -0.66 4.73e-43 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs7666738 0.680 rs11726233 chr4:99079773 G/A cg05340658 chr4:99064831 C4orf37 0.53 7.97 0.4 2.65e-14 Colonoscopy-negative controls vs population controls; CRC cis rs11190604 1.000 rs10509744 chr10:102271579 C/T cg16342193 chr10:102329863 NA -0.36 -6.04 -0.32 4.21e-9 Palmitoleic acid (16:1n-7) levels; CRC cis rs6460942 0.908 rs73677559 chr7:12270819 A/C cg06484146 chr7:12443880 VWDE -0.6 -6.33 -0.33 8.08e-10 Coronary artery disease; CRC cis rs79349575 0.687 rs12602179 chr17:47010034 G/T cg22482690 chr17:47019901 SNF8 0.48 8.01 0.4 2e-14 Type 2 diabetes; CRC cis rs77633900 0.614 rs280028 chr15:77031466 A/G cg21673338 chr15:77095150 SCAPER -0.75 -7.97 -0.4 2.71e-14 Non-glioblastoma glioma;Glioma; CRC cis rs10504229 0.639 rs67996345 chr8:58117127 A/G cg04204079 chr8:58130323 NA -0.45 -5.78 -0.3 1.71e-8 Developmental language disorder (linguistic errors); CRC cis rs208520 0.690 rs10944872 chr6:66708239 T/G cg07460842 chr6:66804631 NA 0.97 13.56 0.6 1.39e-33 Exhaled nitric oxide output; CRC cis rs7259376 0.902 rs11669356 chr19:22605120 G/T cg02657401 chr19:22469223 NA 0.3 6.42 0.33 4.68e-10 Menopause (age at onset); CRC cis rs7833790 0.963 rs28823280 chr8:82777716 G/A cg17211192 chr8:82754475 SNX16 0.54 6.65 0.34 1.22e-10 Diastolic blood pressure; CRC trans rs875971 0.660 rs2191268 chr7:66110224 C/T cg01008941 chr4:39046077 KLHL5 -0.45 -6.94 -0.36 2.06e-11 Aortic root size; CRC cis rs1129187 0.755 rs4714638 chr6:42917017 A/G cg27588902 chr6:42928151 GNMT -0.41 -7.27 -0.37 2.66e-12 Alzheimer's disease in APOE e4+ carriers; CRC cis rs4363385 0.818 rs1334849 chr1:153004652 A/G cg25856811 chr1:152973957 SPRR3 0.23 6.29 0.33 1.02e-9 Inflammatory skin disease; CRC cis rs13256369 0.951 rs12679360 chr8:8566269 G/T cg06671706 chr8:8559999 CLDN23 -0.57 -8.09 -0.41 1.19e-14 Obesity-related traits; CRC cis rs25422 0.938 rs62421538 chr6:118729703 A/T cg01339444 chr6:118972232 C6orf204 0.52 5.89 0.31 9.54e-9 Renal cell carcinoma; CRC cis rs7107174 1.000 rs2450123 chr11:77952771 T/C cg02023728 chr11:77925099 USP35 0.51 7.48 0.38 7.03e-13 Testicular germ cell tumor; CRC cis rs10504229 0.861 rs114700910 chr8:58170642 C/T cg05313129 chr8:58192883 C8orf71 -0.47 -6.93 -0.36 2.23e-11 Developmental language disorder (linguistic errors); CRC cis rs4862750 0.872 rs4862747 chr4:187877236 A/T cg06074448 chr4:187884817 NA 0.58 10.82 0.51 1.52e-23 Lobe attachment (rater-scored or self-reported); CRC cis rs12980942 0.872 rs12985339 chr19:41801756 A/T cg25627403 chr19:41769009 HNRNPUL1 -0.48 -5.7 -0.3 2.74e-8 Coronary artery disease; CRC cis rs877282 0.898 rs11253347 chr10:765769 A/G cg06581033 chr10:766294 NA -0.53 -5.79 -0.3 1.61e-8 Uric acid levels; CRC cis rs9916302 0.904 rs7223438 chr17:37521355 T/C cg15445000 chr17:37608096 MED1 -0.42 -9.25 -0.45 2.82e-18 Glomerular filtration rate (creatinine); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg10663655 chr7:66309627 LOC729156 0.51 7.25 0.37 3.03e-12 Response to antipsychotic treatment; CRC cis rs6952808 0.771 rs10275045 chr7:1920826 C/T cg00106254 chr7:1943704 MAD1L1 -0.44 -6.89 -0.36 2.82e-11 Bipolar disorder and schizophrenia; CRC cis rs10504229 1.000 rs17216648 chr8:58169429 C/T cg21724239 chr8:58056113 NA 0.39 5.6 0.3 4.43e-8 Developmental language disorder (linguistic errors); CRC cis rs9443645 0.901 rs4706077 chr6:79548845 G/A cg09184832 chr6:79620586 NA -0.5 -9.4 -0.46 9.53e-19 Intelligence (multi-trait analysis); CRC cis rs2295359 0.824 rs4655679 chr1:67599657 A/G cg03340356 chr1:67600835 NA -0.31 -6.8 -0.35 4.93e-11 Psoriasis; CRC cis rs25422 0.887 rs9481844 chr6:118990941 G/A cg24463073 chr6:118973353 C6orf204 0.42 6.03 0.32 4.4e-9 Renal cell carcinoma; CRC cis rs9894429 1.000 rs35435780 chr17:79579602 G/T cg21984481 chr17:79567631 NPLOC4 -0.53 -9.8 -0.48 4.52e-20 Eye color traits; CRC cis rs9908102 0.740 rs60713770 chr17:12912385 A/G cg26162695 chr17:12921313 ELAC2 0.43 5.85 0.31 1.17e-8 Schizophrenia; CRC cis rs789852 0.764 rs1773184 chr3:194313832 T/C cg21106136 chr3:194405973 FAM43A -0.71 -5.82 -0.31 1.43e-8 QT interval; CRC cis rs12142240 0.698 rs6703374 chr1:46862332 C/G cg14993813 chr1:46806288 NSUN4 -0.48 -6.03 -0.32 4.47e-9 Menopause (age at onset); CRC cis rs1564271 0.528 rs2489589 chr10:26983095 A/G cg24343755 chr10:26987087 PDSS1 -0.5 -6.66 -0.34 1.14e-10 Overall survival in serous epithelial ovarian cancer treated with paclitaxel and cisplatin; CRC cis rs7113874 0.550 rs10840084 chr11:8609274 G/A cg02811074 chr11:8615871 STK33 0.34 5.86 0.31 1.14e-8 Body mass index in physically active individuals;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs787274 0.543 rs10739377 chr9:115631598 A/G cg13803584 chr9:115635662 SNX30 0.65 6.96 0.36 1.83e-11 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs13096480 0.583 rs17598137 chr3:49891362 G/T cg08991297 chr3:49967416 MON1A 0.41 5.78 0.3 1.7e-8 Intelligence (multi-trait analysis); CRC cis rs13256369 0.760 rs7816171 chr8:8575835 T/C cg06636001 chr8:8085503 FLJ10661 0.44 5.7 0.3 2.72e-8 Obesity-related traits; CRC cis rs7589728 0.620 rs76687350 chr2:88473832 G/A cg24977027 chr2:88469347 THNSL2 0.62 7.41 0.38 1.08e-12 Plasma clusterin levels; CRC cis rs11122272 0.735 rs2790880 chr1:231534259 C/T cg06096015 chr1:231504339 EGLN1 0.4 5.93 0.31 7.49e-9 Hemoglobin concentration; CRC cis rs7618915 0.501 rs3733045 chr3:52643307 A/G cg18099408 chr3:52552593 STAB1 -0.49 -8.34 -0.42 2.13e-15 Bipolar disorder; CRC cis rs7584330 0.554 rs56853932 chr2:238428327 T/C cg14458575 chr2:238380390 NA 0.52 7.08 0.36 8.63e-12 Prostate cancer; CRC cis rs7666738 0.830 rs4699593 chr4:98980628 A/G cg05340658 chr4:99064831 C4orf37 0.6 9.41 0.46 8.57e-19 Colonoscopy-negative controls vs population controls; CRC trans rs61931739 0.500 rs11053217 chr12:34470036 A/C cg26384229 chr12:38710491 ALG10B 0.61 8.96 0.44 2.49e-17 Morning vs. evening chronotype; CRC cis rs243505 0.762 rs933436 chr7:148487329 A/C cg09806900 chr7:148480153 CUL1 -0.5 -7.59 -0.39 3.44e-13 Inflammatory bowel disease;Crohn's disease; CRC cis rs2976388 1.000 rs2976396 chr8:143764001 A/G cg22687807 chr8:143858763 LYNX1 0.36 6.49 0.34 3.22e-10 Urinary tract infection frequency; CRC cis rs736408 0.562 rs13071584 chr3:52804487 T/C cg18404041 chr3:52824283 ITIH1 -0.4 -8.23 -0.41 4.34e-15 Bipolar disorder; CRC cis rs7659604 1.000 rs7659943 chr4:122665560 C/T cg20573242 chr4:122745356 CCNA2 0.42 6.25 0.33 1.25e-9 Type 2 diabetes; CRC cis rs7666738 0.830 rs10022389 chr4:99022229 T/C cg17366294 chr4:99064904 C4orf37 0.43 7.29 0.37 2.28e-12 Colonoscopy-negative controls vs population controls; CRC cis rs8180040 0.593 rs12715421 chr3:47084859 A/G cg27129171 chr3:47204927 SETD2 0.73 11.63 0.54 2e-26 Colorectal cancer; CRC cis rs10751667 0.661 rs6597946 chr11:1037888 A/G ch.11.42038R chr11:967971 AP2A2 0.54 6.93 0.36 2.24e-11 Alzheimer's disease (late onset); CRC cis rs9322193 0.884 rs2095375 chr6:150128173 C/A cg07701084 chr6:150067640 NUP43 0.47 6.61 0.34 1.51e-10 Lung cancer; CRC cis rs936229 0.861 rs7162232 chr15:75115895 G/A cg10253484 chr15:75165896 SCAMP2 -0.4 -5.75 -0.3 2.07e-8 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); CRC cis rs28386778 0.830 rs6504180 chr17:61813169 T/C cg06873352 chr17:61820015 STRADA 0.75 14.06 0.61 1.76e-35 Prudent dietary pattern; CRC cis rs6951245 0.872 rs11768486 chr7:1101290 C/A cg26224354 chr7:1096374 C7orf50;GPR146 -0.93 -12.05 -0.55 5.9e-28 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs6570726 0.526 rs9403699 chr6:145730685 G/T cg23711669 chr6:146136114 FBXO30 0.47 7.49 0.38 6.27e-13 Lobe attachment (rater-scored or self-reported); CRC cis rs7618915 0.501 rs12486554 chr3:52742537 A/T cg11645453 chr3:52864694 ITIH4 0.34 6.14 0.32 2.35e-9 Bipolar disorder; CRC cis rs9311676 0.632 rs11719192 chr3:58431817 C/G cg06643156 chr3:58380774 PXK 0.43 6.56 0.34 2.06e-10 Systemic lupus erythematosus; CRC trans rs2303319 0.504 rs62189047 chr2:162613314 T/A cg23247704 chr1:116518985 SLC22A15 -0.72 -6.14 -0.32 2.42e-9 Cognitive function; CRC cis rs10208940 0.619 rs7567869 chr2:68865293 G/A cg12452813 chr2:68675892 NA 0.54 6.65 0.34 1.2e-10 Urate levels in lean individuals; CRC cis rs6499255 1.000 rs11075734 chr16:69801397 G/T cg00738113 chr16:70207722 CLEC18C -0.39 -5.82 -0.31 1.39e-8 IgE levels; CRC cis rs1865760 0.602 rs9467662 chr6:26021327 G/A cg17691542 chr6:26056736 HIST1H1C 0.56 8.7 0.43 1.63e-16 Height; CRC cis rs672059 0.966 rs689375 chr1:183160973 A/G ch.1.3577855R chr1:183094577 LAMC1 0.5 7.28 0.37 2.41e-12 Hypertriglyceridemia; CRC cis rs4713118 0.669 rs200997 chr6:27811815 G/A cg12172441 chr6:28176163 NA 0.51 6.98 0.36 1.65e-11 Parkinson's disease; CRC cis rs17376456 0.825 rs12716453 chr5:93271697 T/C cg25358565 chr5:93447407 FAM172A 1.1 10.9 0.52 7.71e-24 Diabetic retinopathy; CRC cis rs968567 0.638 rs7943728 chr11:61547068 G/A cg06781209 chr11:61594997 FADS2 -0.73 -8.78 -0.44 9.17e-17 Blood metabolite levels;Rheumatoid arthritis;Vitiligo;Glycerophospholipid levels; CRC cis rs6748734 1.000 rs4675860 chr2:241840417 A/G cg07537917 chr2:241836409 C2orf54 -0.21 -5.66 -0.3 3.27e-8 Urinary metabolites; CRC trans rs7030480 0.606 rs113196649 chr9:71658436 G/A cg07563180 chr1:208452792 NA 0.5 6.12 0.32 2.71e-9 Night sleep phenotypes; CRC trans rs561341 1.000 rs527256 chr17:30321293 C/G cg27661571 chr11:113659931 NA -0.95 -10.99 -0.52 3.76e-24 Hip circumference adjusted for BMI; CRC cis rs17270561 0.609 rs1179086 chr6:25791745 A/T cg17691542 chr6:26056736 HIST1H1C 0.52 7.09 0.36 8.45e-12 Iron status biomarkers; CRC cis rs9818758 0.607 rs9837625 chr3:49215966 C/T cg07636037 chr3:49044803 WDR6 -0.67 -5.79 -0.3 1.64e-8 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; CRC cis rs6860806 0.661 rs2136188 chr5:131577514 A/G cg20512303 chr5:131592959 PDLIM4 -0.37 -7.2 -0.37 4e-12 Breast cancer; CRC cis rs7249142 0.549 rs2239369 chr19:19292405 A/T cg26504305 chr19:19281019 LOC729991-MEF2B;MEF2B 0.44 8.97 0.44 2.27e-17 IgG glycosylation; CRC cis rs10504229 0.600 rs6987243 chr8:58115406 T/C cg21724239 chr8:58056113 NA 0.49 6.81 0.35 4.75e-11 Developmental language disorder (linguistic errors); CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg10944051 chr3:42632258 SS18L2 0.47 6.45 0.34 4.05e-10 Anxiety disorder; CRC cis rs11233250 0.502 rs11233278 chr11:82412597 C/G cg17391194 chr11:82401662 NA 0.39 6.03 0.32 4.39e-9 Glioblastoma;Glioma; CRC cis rs17767294 0.612 rs9461425 chr6:27919688 G/A cg06470822 chr6:28175283 NA 0.81 8.33 0.42 2.26e-15 Parkinson's disease; CRC cis rs1218582 0.772 rs2174507 chr1:154887949 C/T cg16680214 chr1:154839983 KCNN3 -0.46 -9.08 -0.45 1.01e-17 Prostate cancer; CRC cis rs4742903 0.904 rs7028408 chr9:106859811 G/A cg21169611 chr9:106856078 SMC2 0.42 5.95 0.31 7.05e-9 High-grade serous ovarian cancer;Breast cancer; CRC cis rs798554 0.757 rs2644312 chr7:2841164 G/A cg19346786 chr7:2764209 NA -0.4 -7.05 -0.36 1.04e-11 Height; CRC cis rs877282 0.945 rs12776447 chr10:790625 A/G cg06581033 chr10:766294 NA -0.51 -5.68 -0.3 2.97e-8 Uric acid levels; CRC cis rs4713118 0.629 rs203889 chr6:28021775 T/G cg15786705 chr6:28176104 NA 0.69 9.45 0.46 6.46e-19 Parkinson's disease; CRC cis rs9325144 0.600 rs12424410 chr12:38758035 A/T cg13010199 chr12:38710504 ALG10B -0.4 -5.66 -0.3 3.35e-8 Morning vs. evening chronotype; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg08329777 chr17:79885590 LOC92659;MAFG 0.43 6.14 0.32 2.34e-9 Response to antipsychotic treatment; CRC cis rs4925386 0.765 rs6142737 chr20:60919800 C/G cg24112000 chr20:60950667 NA -0.53 -8.37 -0.42 1.73e-15 Colorectal cancer;Colorectal cancer (SNP x SNP interaction); CRC cis rs9322193 0.847 rs9505972 chr6:150096391 A/C cg13206674 chr6:150067644 NUP43 0.67 9.32 0.46 1.7e-18 Lung cancer; CRC cis rs13096760 1 rs13096760 chr3:49476806 T/C cg07636037 chr3:49044803 WDR6 0.56 8.09 0.41 1.15e-14 Intelligence (multi-trait analysis); CRC trans rs7819412 0.668 rs2409721 chr8:11038244 A/T cg06636001 chr8:8085503 FLJ10661 -0.45 -6.69 -0.35 9.45e-11 Triglycerides; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg10729317 chr20:2821390 FAM113A;VPS16 0.4 6.4 0.33 5.2e-10 Liver disease severity in Alagille syndrome; CRC cis rs9837602 0.935 rs9860290 chr3:99839106 C/T cg07805332 chr3:99536008 MIR548G;C3orf26 -0.46 -5.82 -0.31 1.4e-8 Breast cancer; CRC cis rs2739330 0.828 rs4822454 chr22:24255208 G/A cg11060661 chr22:24314208 DDT;DDTL 0.48 8.39 0.42 1.41e-15 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs11122272 0.766 rs2790871 chr1:231543555 G/C cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.63 -9.76 -0.47 6.15e-20 Hemoglobin concentration; CRC cis rs7517126 1.000 rs28413658 chr1:196843400 G/T cg13682187 chr1:196946512 CFHR5 -0.38 -6.16 -0.32 2.09e-9 Blood protein levels; CRC cis rs7605827 0.930 rs2160692 chr2:15637496 C/G cg19274914 chr2:15703543 NA 0.4 6.05 0.32 4e-9 Educational attainment (years of education); CRC cis rs6860806 0.661 rs1588263 chr5:131577158 T/C cg09877947 chr5:131593287 PDLIM4 0.47 8.87 0.44 4.63e-17 Breast cancer; CRC cis rs9549367 0.789 rs7317558 chr13:113893625 G/A cg18105134 chr13:113819100 PROZ -0.74 -11.24 -0.53 4.83e-25 Platelet distribution width; CRC trans rs3780486 0.757 rs10121987 chr9:33119818 A/G cg20290983 chr6:43655470 MRPS18A 1.14 25.93 0.82 1.68e-81 IgG glycosylation; CRC cis rs896854 0.812 rs4582532 chr8:95969257 G/A cg09323728 chr8:95962352 TP53INP1 -0.44 -7.34 -0.38 1.71e-12 Type 2 diabetes; CRC cis rs4919694 0.711 rs113361908 chr10:104978126 T/C cg04362960 chr10:104952993 NT5C2 1.12 9.78 0.47 5.23e-20 Arsenic metabolism; CRC cis rs1348850 0.526 rs10930802 chr2:178460095 A/G cg27490568 chr2:178487706 NA 0.62 7.37 0.38 1.37e-12 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC trans rs9467711 1.000 rs1883215 chr6:26314233 G/C cg15845792 chr6:28175446 NA 0.67 6.22 0.32 1.52e-9 Autism spectrum disorder or schizophrenia; CRC cis rs17345786 1.000 rs997739 chr3:101313940 A/G cg11279151 chr3:101281821 RG9MTD1 -0.71 -8.92 -0.44 3.39e-17 Colonoscopy-negative controls vs population controls; CRC cis rs10751667 1.000 rs7394449 chr11:962190 T/C cg23136738 chr11:925521 AP2A2 -0.51 -8.28 -0.42 3.11e-15 Alzheimer's disease (late onset); CRC trans rs4308415 0.623 rs1390070 chr4:67802169 A/C cg19648955 chr2:177134095 MTX2 -0.41 -5.99 -0.31 5.44e-9 Educational attainment (years of education); CRC cis rs10046574 0.831 rs7785527 chr7:135063685 C/T cg27474649 chr7:135195673 CNOT4 0.68 5.72 0.3 2.39e-8 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs9325144 0.600 rs1817648 chr12:38733424 C/T cg13010199 chr12:38710504 ALG10B -0.41 -6.04 -0.32 4.27e-9 Morning vs. evening chronotype; CRC cis rs9611565 0.918 rs9611561 chr22:41757234 C/G cg03806693 chr22:41940476 POLR3H -1.02 -13.24 -0.59 2.32e-32 Vitiligo; CRC cis rs1046896 1.000 rs1046896 chr17:80685533 A/G cg02398342 chr17:80708632 TBCD;FN3K -0.36 -5.84 -0.31 1.27e-8 Glycated hemoglobin levels; CRC cis rs7113874 0.610 rs12576736 chr11:8512281 A/C cg02811074 chr11:8615871 STK33 -0.36 -6.17 -0.32 1.95e-9 Body mass index in physically active individuals;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs9467773 1.000 rs6903973 chr6:26499942 C/A cg09904177 chr6:26538194 HMGN4 0.85 14.49 0.62 3.83e-37 Intelligence (multi-trait analysis); CRC cis rs427941 0.632 rs201475 chr7:101745883 G/T cg06246474 chr7:101738831 CUX1 0.44 6.78 0.35 5.45e-11 Plasma omega-3 polyunsaturated fatty acid level (eicosapentaenoic acid); CRC cis rs6570726 0.738 rs7746330 chr6:145899257 A/C cg13319975 chr6:146136371 FBXO30 -0.42 -6.17 -0.32 1.98e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs2115630 0.936 rs8033459 chr15:85253258 C/T cg11189052 chr15:85197271 WDR73 -0.62 -10.09 -0.49 4.97e-21 P wave terminal force; CRC trans rs459571 0.920 rs460154 chr9:136909309 C/T cg09836344 chr4:1243392 C4orf42;CTBP1 -0.79 -11.4 -0.53 1.32e-25 Platelet distribution width; CRC cis rs4728302 0.838 rs10225454 chr7:133591535 G/C cg03336402 chr7:133662267 EXOC4 -0.45 -6.56 -0.34 2.04e-10 Intelligence;Intelligence (multi-trait analysis); CRC cis rs1707322 0.752 rs10789467 chr1:46118745 C/G cg03146154 chr1:46216737 IPP 0.67 9.74 0.47 7.45e-20 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs66573146 0.831 rs73088564 chr4:6984553 G/C cg00086871 chr4:6988644 TBC1D14 1.02 8.54 0.43 4.99e-16 Granulocyte percentage of myeloid white cells; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg15617548 chr2:171785815 GORASP2 0.53 8.69 0.43 1.74e-16 Liver disease severity in Alagille syndrome; CRC cis rs929596 0.564 rs2741038 chr2:234563998 G/A cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.47 -6.13 -0.32 2.49e-9 Total bilirubin levels in HIV-1 infection; CRC cis rs9733 0.566 rs11204675 chr1:150570985 A/C cg15448220 chr1:150897856 SETDB1 -0.38 -5.76 -0.3 1.89e-8 Tonsillectomy; CRC cis rs12824058 0.831 rs12831363 chr12:130814013 C/T cg26677194 chr12:130822605 PIWIL1 -0.44 -7.13 -0.37 6.23e-12 Menopause (age at onset); CRC cis rs9372498 0.536 rs62422224 chr6:118941116 G/A cg22561889 chr6:118971681 C6orf204 0.48 5.92 0.31 8.26e-9 Diastolic blood pressure; CRC cis rs78456975 0.527 rs4073862 chr2:1563433 A/G cg26248373 chr2:1572462 NA -0.83 -11.59 -0.54 2.92e-26 Placebo response in major depressive disorder (% change in symptom score); CRC cis rs6062302 0.522 rs6090476 chr20:62248001 G/A cg06363034 chr20:62225388 GMEB2 -0.45 -6.88 -0.35 3.01e-11 Glioblastoma; CRC cis rs1401999 0.650 rs3749445 chr3:183638506 C/T cg01324343 chr3:183735012 ABCC5 0.6 9.54 0.47 3.45e-19 Anterior chamber depth; CRC cis rs2108225 0.967 rs6979054 chr7:107447488 A/C cg18560240 chr7:107437656 SLC26A3 -0.55 -8.27 -0.41 3.34e-15 Ulcerative colitis; CRC cis rs2072510 0.569 rs61937881 chr12:96393587 C/T cg15438951 chr12:96389694 HAL -0.49 -5.93 -0.31 7.65e-9 Metabolite levels (small molecules and protein measures); CRC cis rs2075371 0.897 rs10488428 chr7:133997560 C/T cg11752832 chr7:134001865 SLC35B4 0.43 6.22 0.32 1.5e-9 Mean platelet volume; CRC cis rs7680126 0.596 rs10939835 chr4:10313750 A/G cg11266682 chr4:10021025 SLC2A9 -0.5 -7.25 -0.37 2.95e-12 Urate levels in lean individuals;Urate levels in overweight individuals;Urate levels in obese individuals; CRC cis rs7312933 1.000 rs7312933 chr12:42503467 C/T cg17420585 chr12:42539391 GXYLT1 0.39 5.67 0.3 3.19e-8 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CRC cis rs1808579 0.904 rs2960578 chr18:21143739 A/C cg14672496 chr18:21087552 C18orf8 0.37 6.25 0.33 1.28e-9 Hip circumference;Body mass index;BMI (adjusted for smoking behaviour); CRC cis rs847577 0.722 rs1013887 chr7:97709345 G/T cg00277769 chr7:97922759 BAIAP2L1 -0.41 -7.04 -0.36 1.16e-11 Breast cancer; CRC cis rs6860806 0.507 rs200837 chr5:131699958 G/A cg22638593 chr5:131593259 PDLIM4 0.39 6.36 0.33 6.64e-10 Breast cancer; CRC cis rs5769765 0.908 rs9616390 chr22:50314289 G/C cg22709217 chr22:50311962 ALG12;CRELD2 -1.12 -18.3 -0.71 4.39e-52 Schizophrenia; CRC cis rs798554 0.797 rs798486 chr7:2803037 A/G cg14895029 chr7:2775587 GNA12 -0.45 -6.52 -0.34 2.59e-10 Height; CRC cis rs8078723 1.000 rs1042658 chr17:38173902 C/T cg17467752 chr17:38218738 THRA 0.73 11.97 0.55 1.17e-27 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); CRC cis rs3862030 0.720 rs7342070 chr10:104223628 T/C cg11453585 chr10:104263688 ACTR1A;SUFU -0.8 -13.76 -0.6 2.33e-34 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for body mass index; CRC cis rs734999 0.588 rs2260976 chr1:2527678 A/G cg20673091 chr1:2541236 MMEL1 -0.37 -5.96 -0.31 6.65e-9 Ulcerative colitis; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg18527133 chr12:71834707 LGR5 0.51 7.81 0.4 7.73e-14 Liver disease severity in Alagille syndrome; CRC cis rs4665809 1.000 rs4233708 chr2:26291345 C/T cg22920501 chr2:26401640 FAM59B -0.52 -7.15 -0.37 5.6e-12 Gut microbiome composition (summer); CRC trans rs6703335 0.870 rs10803142 chr1:243598234 A/G cg03183882 chr3:15373315 SH3BP5 0.47 6.65 0.34 1.25e-10 Schizophrenia;Schizophrenia, schizoaffective disorder or bipolar disorder; CRC trans rs7937682 0.924 rs499750 chr11:111513645 T/G cg18187862 chr3:45730750 SACM1L 0.5 7.12 0.37 6.79e-12 Primary sclerosing cholangitis; CRC cis rs1223397 0.938 rs13205692 chr6:13291560 C/T cg21538684 chr6:13274180 PHACTR1 0.48 5.63 0.3 3.89e-8 Blood pressure; CRC cis rs1008375 0.966 rs4698636 chr4:17632834 T/C cg04450456 chr4:17643702 FAM184B 0.42 6.74 0.35 7.03e-11 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs9322193 0.884 rs9689702 chr6:150061856 G/A cg13206674 chr6:150067644 NUP43 0.66 10.02 0.48 8.65e-21 Lung cancer; CRC trans rs7267979 1.000 rs2257808 chr20:25266450 G/C cg17903999 chr18:56338584 MALT1 -0.42 -7.0 -0.36 1.41e-11 Liver enzyme levels (alkaline phosphatase); CRC cis rs12586317 0.547 rs74243586 chr14:35477325 C/T cg16230307 chr14:35515116 FAM177A1 0.85 9.81 0.48 4.4e-20 Psoriasis; CRC cis rs13631 0.728 rs7466635 chr9:139980417 T/C cg04545659 chr9:139973827 UAP1L1 -0.49 -7.95 -0.4 3e-14 Cerebrospinal fluid biomarker levels; CRC cis rs79387448 0.638 rs6759588 chr2:103040159 A/G cg00507830 chr2:103233733 NA 0.6 5.95 0.31 6.78e-9 Gut microbiota (bacterial taxa); CRC cis rs524281 0.817 rs10896092 chr11:65958046 A/C cg14036092 chr11:66035641 RAB1B -0.45 -5.61 -0.3 4.26e-8 Electroencephalogram traits; CRC cis rs853679 0.517 rs9357066 chr6:28129831 T/C cg21251018 chr6:28226885 NKAPL 0.48 6.17 0.32 2.02e-9 Depression; CRC trans rs7395662 0.963 rs12365014 chr11:48629434 C/T cg21153622 chr11:89784906 NA -0.45 -7.29 -0.37 2.26e-12 HDL cholesterol; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg17727989 chr9:27529519 MOBKL2B 0.41 5.97 0.31 6.06e-9 Intelligence (multi-trait analysis); CRC cis rs9811920 0.809 rs793437 chr3:99559854 C/A cg07805332 chr3:99536008 MIR548G;C3orf26 0.39 6.05 0.32 4e-9 Axial length; CRC cis rs6840360 0.642 rs2709817 chr4:152382050 A/G cg09659197 chr4:152720779 NA 0.33 6.57 0.34 1.94e-10 Intelligence (multi-trait analysis); CRC cis rs8044868 0.530 rs2550868 chr16:72066072 G/A cg23815491 chr16:72088622 HP 0.52 7.62 0.39 2.66e-13 Body mass index (change over time) in cancer or chronic obstructive pulmonary disease;Body mass index (change over time) in cancer; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg04607442 chr13:21872219 NA -0.41 -6.02 -0.31 4.75e-9 Myopia (pathological); CRC cis rs9916302 0.904 rs650106 chr17:37451559 A/G cg07936489 chr17:37558343 FBXL20 0.82 12.72 0.57 2.08e-30 Glomerular filtration rate (creatinine); CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg04232674 chr1:150601743 ENSA 0.5 6.31 0.33 8.97e-10 Thyroid stimulating hormone; CRC cis rs4563143 0.663 rs2218396 chr19:29236392 C/T cg12756686 chr19:29218302 NA 0.62 9.57 0.47 2.57e-19 Methadone dose in opioid dependence; CRC cis rs7552404 0.727 rs5745390 chr1:76306591 A/C cg03433033 chr1:76189801 ACADM 0.71 9.35 0.46 1.44e-18 Blood metabolite levels;Acylcarnitine levels; CRC trans rs6500957 0.920 rs17648524 chr16:7459683 C/G cg09351035 chr11:748060 TALDO1 0.46 6.68 0.35 1.02e-10 Spherical equivalent (joint analysis main effects and education interaction); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg11309891 chr11:73388802 RAB6A -0.43 -7.02 -0.36 1.27e-11 Liver disease severity in Alagille syndrome; CRC cis rs6502050 0.835 rs8065565 chr17:80115399 A/G cg11859384 chr17:80120422 CCDC57 -0.37 -5.98 -0.31 5.86e-9 Life satisfaction; CRC cis rs11809207 0.523 rs2186232 chr1:26502676 T/A cg24519413 chr1:26490540 NA 0.45 7.36 0.38 1.51e-12 Height; CRC cis rs7917772 0.503 rs7915589 chr10:104299264 G/A cg22532475 chr10:104410764 TRIM8 -0.36 -6.8 -0.35 5.08e-11 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC cis rs7178572 0.568 rs12911371 chr15:77689050 C/T cg22256960 chr15:77711686 NA -0.66 -9.6 -0.47 2.13e-19 Type 2 diabetes; CRC cis rs11628318 0.570 rs4906231 chr14:103062227 T/C cg08075719 chr14:103021372 NA -0.68 -7.93 -0.4 3.47e-14 Platelet count; CRC cis rs8114671 0.562 rs6088655 chr20:33527838 A/G cg07148914 chr20:33460835 GGT7 0.4 6.54 0.34 2.36e-10 Height; CRC cis rs17384381 1.000 rs12135333 chr1:85890494 C/A cg16011679 chr1:85725395 C1orf52 0.63 6.49 0.34 3.1e-10 Lobe attachment (rater-scored or self-reported); CRC cis rs3820068 0.603 rs41270279 chr1:15988878 A/G cg24675056 chr1:15929824 NA 0.54 7.31 0.37 2.07e-12 Systolic blood pressure; CRC cis rs9649213 0.593 rs62478233 chr7:98023092 T/C cg00277769 chr7:97922759 BAIAP2L1 -0.57 -9.69 -0.47 1.11e-19 Prostate cancer (SNP x SNP interaction); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg09123307 chr7:6746650 ZNF12 0.37 6.26 0.33 1.19e-9 Liver disease severity in Alagille syndrome; CRC cis rs7264396 0.676 rs1341603 chr20:34556216 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.61 -9.86 -0.48 2.94e-20 Total cholesterol levels; CRC cis rs9372498 0.536 rs9489457 chr6:118920285 C/T cg07617317 chr6:118971624 C6orf204 0.49 6.07 0.32 3.58e-9 Diastolic blood pressure; CRC cis rs807029 0.758 rs807027 chr10:102764607 T/A cg04662943 chr10:102668895 NA 0.66 7.74 0.39 1.27e-13 Ejection fraction in Tripanosoma cruzi seropositivity; CRC cis rs10256972 0.504 rs2949178 chr7:1209925 T/C cg16145915 chr7:1198662 ZFAND2A -0.6 -13.64 -0.6 7.19e-34 Longevity;Endometriosis; CRC cis rs1707322 0.682 rs28490344 chr1:46197948 C/T cg03146154 chr1:46216737 IPP 0.68 9.94 0.48 1.59e-20 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg03193349 chr6:139309610 REPS1 0.45 6.61 0.34 1.59e-10 Intelligence (multi-trait analysis); CRC cis rs34779708 0.931 rs11593858 chr10:35381373 G/A cg03585969 chr10:35415529 CREM 0.67 8.87 0.44 4.78e-17 Inflammatory bowel disease;Crohn's disease; CRC cis rs10504229 0.861 rs114700910 chr8:58170642 C/T cg02290350 chr8:58132656 NA -0.42 -5.94 -0.31 7.42e-9 Developmental language disorder (linguistic errors); CRC cis rs116095464 0.850 rs10055295 chr5:243749 G/A cg22496380 chr5:211416 CCDC127 -0.91 -10.41 -0.5 4.13e-22 Breast cancer; CRC cis rs2304069 0.954 rs9324640 chr5:149413186 C/T cg22760475 chr5:149380129 HMGXB3;TIGD6 -0.77 -9.16 -0.45 5.8e-18 HIV-1 control; CRC cis rs1008375 0.898 rs4698620 chr4:17587361 C/T cg02297831 chr4:17616191 MED28 0.45 5.8 0.3 1.6e-8 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs853679 0.517 rs35512245 chr6:28079953 T/C cg15786705 chr6:28176104 NA 0.76 9.45 0.46 6.35e-19 Depression; CRC cis rs3815700 0.844 rs444089 chr19:33106991 G/C cg02997394 chr19:33096574 ANKRD27 0.66 7.14 0.37 5.94e-12 Eosinophilic esophagitis; CRC cis rs12042938 0.507 rs1655299 chr1:231732161 C/T cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.61 -9.24 -0.45 3.13e-18 Neuranatomic and neurocognitive phenotypes; CRC cis rs9611565 0.659 rs73178641 chr22:41952075 A/T cg06634786 chr22:41940651 POLR3H -0.71 -8.28 -0.42 3.22e-15 Vitiligo; CRC cis rs9311676 0.632 rs67904096 chr3:58365508 T/A cg06643156 chr3:58380774 PXK 0.42 6.55 0.34 2.17e-10 Systemic lupus erythematosus; CRC cis rs7618915 0.547 rs62255371 chr3:52747321 A/G cg18404041 chr3:52824283 ITIH1 -0.43 -8.71 -0.43 1.54e-16 Bipolar disorder; CRC cis rs875971 0.660 rs2191268 chr7:66110224 C/T cg12512039 chr7:65958832 NA -0.36 -5.64 -0.3 3.65e-8 Aortic root size; CRC cis rs870825 0.721 rs72703528 chr4:185607311 A/G cg04058563 chr4:185651563 MLF1IP 0.65 6.55 0.34 2.25e-10 Blood protein levels; CRC cis rs7914558 0.869 rs10883842 chr10:104941589 C/T cg15744005 chr10:104629667 AS3MT -0.34 -7.32 -0.37 1.94e-12 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs2204008 0.744 rs11514071 chr12:38392076 C/T cg26384229 chr12:38710491 ALG10B 0.7 9.66 0.47 1.29e-19 Bladder cancer; CRC cis rs7618915 0.570 rs4687633 chr3:52630548 G/A cg18404041 chr3:52824283 ITIH1 -0.42 -8.75 -0.43 1.14e-16 Bipolar disorder; CRC cis rs992157 0.835 rs4674282 chr2:219144230 A/T cg13835894 chr2:219148914 PNKD;TMBIM1 -0.35 -6.81 -0.35 4.59e-11 Colorectal cancer; CRC cis rs11696501 0.694 rs4812943 chr20:44260966 G/C cg11783356 chr20:44313418 WFDC10B -0.37 -5.65 -0.3 3.41e-8 Brain structure; CRC cis rs2342371 0.720 rs61345811 chr3:196143030 C/T cg15048948 chr3:196158458 UBXN7 0.5 6.18 0.32 1.93e-9 Fat distribution (HIV); CRC cis rs10883723 0.810 rs1884929 chr10:104275418 C/T cg04362960 chr10:104952993 NT5C2 -0.42 -5.94 -0.31 7.28e-9 Allergic disease (asthma, hay fever or eczema); CRC cis rs9388451 0.839 rs9321054 chr6:126079968 A/G cg10911889 chr6:126070802 HEY2 -0.38 -5.94 -0.31 7.29e-9 Brugada syndrome; CRC cis rs3733585 0.699 rs6449158 chr4:9960459 T/C cg11266682 chr4:10021025 SLC2A9 -0.47 -9.64 -0.47 1.58e-19 Cleft plate (environmental tobacco smoke interaction); CRC cis rs4332037 0.539 rs62444881 chr7:2052318 C/T cg21155852 chr7:2048760 MAD1L1 -0.52 -6.87 -0.35 3.24e-11 Bipolar disorder; CRC cis rs950169 1.000 rs950169 chr15:84706461 C/T cg03959625 chr15:84868606 LOC388152 0.42 6.14 0.32 2.34e-9 Schizophrenia; CRC cis rs7412746 0.524 rs58304714 chr1:150831561 T/A cg15448220 chr1:150897856 SETDB1 0.55 7.74 0.39 1.22e-13 Melanoma; CRC cis rs9640161 0.789 rs3735174 chr7:150020489 T/C cg12556325 chr7:150026731 C7orf29;LRRC61 -0.41 -6.2 -0.32 1.66e-9 Blood protein levels;Circulating chemerin levels; CRC cis rs9325144 0.555 rs28738714 chr12:38706912 G/A cg26384229 chr12:38710491 ALG10B -0.55 -8.11 -0.41 1.05e-14 Morning vs. evening chronotype; CRC cis rs523522 0.962 rs12814055 chr12:120987391 G/A cg27279351 chr12:120934652 DYNLL1 0.77 11.31 0.53 2.78e-25 High light scatter reticulocyte count; CRC cis rs4268898 0.717 rs3731626 chr2:24427864 G/A cg06627628 chr2:24431161 ITSN2 -0.66 -9.04 -0.45 1.37e-17 Asthma; CRC cis rs2153535 0.580 rs9328488 chr6:8529411 G/C cg21535247 chr6:8435926 SLC35B3 0.49 7.45 0.38 8.34e-13 Motion sickness; CRC cis rs72781680 0.665 rs2675356 chr2:24074734 C/T cg08917208 chr2:24149416 ATAD2B 0.57 6.93 0.36 2.18e-11 Lymphocyte counts; CRC cis rs10486722 0.607 rs6463036 chr7:41753786 G/A cg22138096 chr7:41772439 LOC285954 0.53 6.73 0.35 7.76e-11 Pit-and-Fissure caries; CRC trans rs12517041 0.935 rs36035239 chr5:23294107 A/G ch.8.1293020R chr8:59333349 UBXN2B -0.55 -6.17 -0.32 2.05e-9 Calcium levels; CRC cis rs1552244 1.000 rs67852463 chr3:10157205 G/C cg00166722 chr3:10149974 C3orf24 0.73 9.61 0.47 1.98e-19 Alzheimer's disease; CRC trans rs208515 0.525 rs1484577 chr6:66688397 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.91 11.64 0.54 1.78e-26 Exhaled nitric oxide levels; CRC cis rs2227564 0.597 rs2633305 chr10:75652123 A/G cg00564723 chr10:75632066 CAMK2G -0.33 -7.63 -0.39 2.58e-13 Crohn's disease;Inflammatory bowel disease; CRC cis rs7129220 0.512 rs2119991 chr11:10226268 A/G cg23875677 chr11:10229755 SBF2 -0.52 -5.9 -0.31 8.91e-9 Systolic blood pressure;Diastolic blood pressure;Blood pressure; CRC cis rs7772486 0.875 rs56181683 chr6:146286620 A/G cg23711669 chr6:146136114 FBXO30 -0.61 -10.12 -0.49 3.97e-21 Lobe attachment (rater-scored or self-reported); CRC cis rs909002 0.800 rs7529064 chr1:32105192 C/A cg01639898 chr1:32083012 HCRTR1 0.31 6.23 0.33 1.39e-9 Intelligence (multi-trait analysis); CRC cis rs7408868 1.000 rs10420466 chr19:15261371 G/T cg14696996 chr19:15285081 NOTCH3 1.01 8.98 0.44 2.13e-17 Pulse pressure; CRC trans rs916888 0.697 rs199516 chr17:44856485 C/T cg01341218 chr17:43662625 NA -0.83 -9.45 -0.46 6.4e-19 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs7119 0.651 rs8025968 chr15:77839616 C/T cg10437265 chr15:77819839 NA 0.67 11.67 0.54 1.48e-26 Type 2 diabetes; CRC cis rs9486719 1.000 rs11152968 chr6:96908653 A/G cg06623918 chr6:96969491 KIAA0776 0.76 8.96 0.44 2.42e-17 Migraine;Coronary artery disease; CRC cis rs2213920 0.620 rs7852799 chr9:118188696 T/C cg13918206 chr9:118159781 DEC1 0.62 5.96 0.31 6.67e-9 Docetaxel-induced peripheral neuropathy in metastatic castrate-resistant prostate cancer; CRC cis rs9303401 0.659 rs2072316 chr17:56604813 G/T cg10487724 chr17:56770010 TEX14;RAD51C 0.8 9.68 0.47 1.12e-19 Cognitive test performance; CRC cis rs460214 0.564 rs9979888 chr21:40022099 A/G cg05519781 chr21:40033154 ERG 0.41 5.85 0.31 1.2e-8 Response to cognitive-behavioural therapy in anxiety disorder; CRC cis rs6570726 0.599 rs426371 chr6:145886469 A/G cg23711669 chr6:146136114 FBXO30 -0.65 -9.77 -0.47 5.83e-20 Lobe attachment (rater-scored or self-reported); CRC cis rs3862260 0.509 rs3862262 chr1:120161841 G/T cg11530693 chr1:120165357 ZNF697 0.61 9.79 0.47 5.09e-20 Systemic lupus erythematosus; CRC cis rs763014 0.932 rs2269560 chr16:682442 A/C cg04562611 chr16:615315 C16orf11 0.35 5.85 0.31 1.21e-8 Height; CRC cis rs9297145 0.673 rs12531875 chr7:98724730 C/T cg05967295 chr7:98741636 SMURF1 1.1 15.62 0.65 1.55e-41 Crohn's disease;Inflammatory bowel disease;Ulcerative colitis; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg14329673 chr8:95732141 DPY19L4 0.36 6.03 0.32 4.52e-9 Liver disease severity in Alagille syndrome; CRC cis rs853679 0.517 rs9295758 chr6:28120663 C/G cg06470822 chr6:28175283 NA 1.03 13.59 0.6 1.04e-33 Depression; CRC cis rs1577917 0.958 rs9647601 chr6:86449827 C/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.54 -7.29 -0.37 2.36e-12 Response to antipsychotic treatment; CRC cis rs787274 0.850 rs10759604 chr9:115639748 G/A cg13803584 chr9:115635662 SNX30 -0.66 -5.97 -0.31 6.04e-9 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs7086627 0.515 rs4933390 chr10:82213081 A/C cg09626299 chr10:82213104 TSPAN14 -0.36 -5.97 -0.31 6.25e-9 Post bronchodilator FEV1; CRC cis rs2688608 0.620 rs7076525 chr10:75512797 C/T cg23231163 chr10:75533350 FUT11 -0.36 -5.63 -0.3 3.81e-8 Inflammatory bowel disease; CRC trans rs1908814 0.516 rs11996277 chr8:11800031 G/A cg06636001 chr8:8085503 FLJ10661 0.49 7.21 0.37 3.79e-12 Neuroticism; CRC cis rs881375 0.967 rs1860824 chr9:123659339 G/T cg00246817 chr9:123691163 NA -0.47 -5.97 -0.31 6.26e-9 Rheumatoid arthritis; CRC trans rs3942852 0.774 rs10838814 chr11:48187178 G/A cg15704280 chr7:45808275 SEPT13 -0.75 -9.3 -0.46 2.07e-18 Acute lymphoblastic leukemia (childhood); CRC cis rs2836974 0.897 rs2836927 chr21:40543216 T/C cg11890956 chr21:40555474 PSMG1 1.08 18.6 0.72 2.69e-53 Cognitive function; CRC cis rs2730260 0.537 rs3793222 chr7:158863536 A/C cg02254261 chr7:158964346 NA 0.45 5.67 0.3 3.08e-8 Myopia (pathological); CRC cis rs11098499 0.644 rs7693919 chr4:120540571 G/A cg24375607 chr4:120327624 NA 0.49 7.67 0.39 1.96e-13 Corneal astigmatism; CRC trans rs1005277 0.602 rs1831315 chr10:38473353 T/C cg11292332 chr7:45801988 SEPT13 -0.38 -6.77 -0.35 5.83e-11 Extrinsic epigenetic age acceleration; CRC cis rs2303759 0.918 rs1054770 chr19:49878115 G/A cg24324837 chr19:49891574 CCDC155 0.58 8.36 0.42 1.82e-15 Multiple sclerosis; CRC cis rs8060686 0.641 rs113502835 chr16:68238965 A/T cg26727032 chr16:67993705 SLC12A4 -0.53 -6.24 -0.33 1.37e-9 HDL cholesterol;Metabolic syndrome; CRC trans rs11098499 0.909 rs10017335 chr4:120381523 C/G cg25214090 chr10:38739885 LOC399744 -0.62 -9.62 -0.47 1.85e-19 Corneal astigmatism; CRC cis rs10504229 0.728 rs17804624 chr8:58154216 T/C cg08219700 chr8:58056026 NA 0.45 5.74 0.3 2.11e-8 Developmental language disorder (linguistic errors); CRC cis rs6502050 0.805 rs7406137 chr17:80084465 T/C cg13198984 chr17:80129470 CCDC57 -0.5 -8.89 -0.44 4.15e-17 Life satisfaction; CRC cis rs12291225 0.679 rs4756786 chr11:14285900 C/A cg05501817 chr11:14380813 RRAS2 -0.45 -5.92 -0.31 7.92e-9 Sense of smell; CRC cis rs6951245 0.935 rs112554101 chr7:1065535 A/G cg04025307 chr7:1156635 C7orf50 0.58 7.0 0.36 1.48e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs10479542 0.784 rs4701132 chr5:178985270 A/G cg19626725 chr5:178986131 RUFY1 -0.38 -7.64 -0.39 2.33e-13 Lung cancer; CRC cis rs13108904 0.901 rs4516656 chr4:1279860 A/G cg02018176 chr4:1364513 KIAA1530 0.48 7.84 0.4 6.25e-14 Obesity-related traits; CRC cis rs2777491 0.574 rs28700583 chr15:41714072 C/T cg18705301 chr15:41695430 NDUFAF1 -1.13 -20.54 -0.75 6.64e-61 Ulcerative colitis; CRC trans rs13046373 0.905 rs4816372 chr21:32077414 A/T cg20466045 chr21:30445936 CCT8 -0.41 -6.08 -0.32 3.32e-9 HDL cholesterol; CRC cis rs13064411 0.696 rs9808893 chr3:113228444 G/A cg18753928 chr3:113234510 CCDC52 -0.7 -10.74 -0.51 2.89e-23 Response to simvastatin treatment (PCSK9 protein level change); CRC cis rs727563 0.638 rs5996058 chr22:42141452 A/G cg17554472 chr22:41940697 POLR3H 0.55 5.66 0.3 3.31e-8 Crohn's disease;Inflammatory bowel disease; CRC cis rs802075 0.967 rs802068 chr6:49657330 C/T cg20364632 chr6:49636226 NA -0.36 -5.88 -0.31 9.95e-9 Bone mineral density (hip) and age at menarche; CRC cis rs4713118 0.824 rs742046 chr6:27739254 A/G cg08798685 chr6:27730294 NA -0.49 -6.91 -0.36 2.59e-11 Parkinson's disease; CRC cis rs72945132 0.769 rs3781644 chr11:70190375 G/A cg00319359 chr11:70116639 PPFIA1 0.57 6.23 0.32 1.43e-9 Coronary artery disease; CRC cis rs7584330 0.666 rs6760963 chr2:238398268 C/T cg14458575 chr2:238380390 NA -0.58 -7.83 -0.4 6.96e-14 Prostate cancer; CRC cis rs7493 1.000 rs12155103 chr7:95037131 G/A cg19678392 chr7:94953810 PON1 -0.57 -7.2 -0.37 4.21e-12 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs11971779 0.648 rs6467852 chr7:139112591 A/C cg07862535 chr7:139043722 LUC7L2 0.57 7.35 0.38 1.61e-12 Diisocyanate-induced asthma; CRC cis rs1862618 0.853 rs252902 chr5:56116085 A/G cg20203395 chr5:56204925 C5orf35 -0.69 -8.47 -0.42 8.19e-16 Initial pursuit acceleration; CRC cis rs10504229 1.000 rs67039591 chr8:58174553 T/A cg02725872 chr8:58115012 NA -0.38 -6.43 -0.33 4.44e-10 Developmental language disorder (linguistic errors); CRC cis rs2050392 0.590 rs694346 chr10:30711929 C/T cg25182066 chr10:30743637 MAP3K8 -0.45 -6.07 -0.32 3.55e-9 Inflammatory bowel disease; CRC cis rs896854 0.654 rs2011566 chr8:95971921 G/A cg23172400 chr8:95962367 TP53INP1 -0.46 -7.75 -0.39 1.12e-13 Type 2 diabetes; CRC cis rs11997175 0.568 rs4733169 chr8:33581855 T/C ch.8.33884649F chr8:33765107 NA 0.36 5.6 0.3 4.44e-8 Body mass index; CRC cis rs4803480 0.766 rs723902 chr19:42084182 G/C cg08478046 chr19:42093086 CEACAM21 -0.31 -6.21 -0.32 1.61e-9 Schizophrenia; CRC cis rs7615952 0.641 rs7640158 chr3:125808011 G/A cg06494592 chr3:125709126 NA -0.58 -6.85 -0.35 3.57e-11 Blood pressure (smoking interaction); CRC cis rs477895 1.000 rs7947143 chr11:64090422 G/A cg18225595 chr11:63971243 STIP1 0.59 6.24 0.33 1.35e-9 Mean platelet volume; CRC cis rs1552244 0.816 rs56387520 chr3:10042782 C/T cg13047869 chr3:10149882 C3orf24 0.51 6.97 0.36 1.74e-11 Alzheimer's disease; CRC cis rs10256972 0.684 rs2363279 chr7:1096143 A/G cg23708337 chr7:1209742 NA 0.39 5.79 0.3 1.69e-8 Longevity;Endometriosis; CRC cis rs7618915 0.547 rs68021750 chr3:52624769 G/A cg18404041 chr3:52824283 ITIH1 -0.43 -8.72 -0.43 1.39e-16 Bipolar disorder; CRC cis rs1348850 0.526 rs78587445 chr2:178461339 G/T cg27490568 chr2:178487706 NA -0.66 -7.02 -0.36 1.32e-11 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC trans rs3857536 0.605 rs36040831 chr6:66876588 G/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.65 -9.19 -0.45 4.55e-18 Blood trace element (Cu levels); CRC cis rs2976388 0.578 rs34956412 chr8:143822028 C/T cg04969067 chr8:143858791 LYNX1 -0.41 -6.12 -0.32 2.64e-9 Urinary tract infection frequency; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg23123679 chr12:49351256 ARF3 0.44 6.17 0.32 2.05e-9 Response to antipsychotic treatment; CRC cis rs7259376 0.601 rs7251483 chr19:22494136 G/A cg02657401 chr19:22469223 NA -0.31 -6.63 -0.34 1.41e-10 Menopause (age at onset); CRC trans rs1728785 1.000 rs1170428 chr16:68603988 C/A cg04657470 chr2:198365150 HSPE1;HSPD1 0.75 8.94 0.44 2.86e-17 Ulcerative colitis; CRC cis rs4728302 0.869 rs6955240 chr7:133581873 G/A cg03336402 chr7:133662267 EXOC4 -0.43 -6.28 -0.33 1.05e-9 Intelligence;Intelligence (multi-trait analysis); CRC cis rs939584 1.000 rs11127488 chr2:646061 T/C cg03610516 chr2:642275 NA 0.42 5.87 0.31 1.06e-8 Body mass index; CRC cis rs17433780 0.808 rs12122780 chr1:89508916 T/C cg09516651 chr1:89888402 LOC400759 0.5 7.85 0.4 5.87e-14 Carotid intima media thickness; CRC cis rs231513 0.911 rs537165 chr17:41976736 C/T cg26893861 chr17:41843967 DUSP3 -0.63 -6.36 -0.33 6.63e-10 Cognitive function; CRC cis rs763121 0.853 rs6001175 chr22:39018334 T/C cg06544989 chr22:39130855 UNC84B 0.46 7.43 0.38 9.54e-13 Menopause (age at onset); CRC trans rs7615952 0.543 rs4645102 chr3:125424441 A/G cg02007433 chr3:129722099 NA -0.61 -9.36 -0.46 1.32e-18 Blood pressure (smoking interaction); CRC trans rs10050311 0.698 rs10516778 chr4:87636051 G/A cg00004207 chr2:38977301 SFRS7 0.5 6.07 0.32 3.56e-9 Insulin-related traits; CRC cis rs651907 0.557 rs7651406 chr3:101393296 C/T cg11279151 chr3:101281821 RG9MTD1 -0.5 -6.87 -0.35 3.12e-11 Colorectal cancer; CRC cis rs798766 1.000 rs798762 chr4:1731150 T/C cg05874882 chr4:1763078 NA -0.38 -7.18 -0.37 4.67e-12 Bladder cancer;Urinary bladder cancer; CRC trans rs9858542 0.953 rs71324979 chr3:49619651 T/C cg21665057 chr3:196295764 WDR53;FBXO45 -0.7 -9.38 -0.46 1.09e-18 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs769267 1.000 rs2074090 chr19:19449686 G/T cg01262667 chr19:19385393 TM6SF2 -0.38 -6.28 -0.33 1.07e-9 Tonsillectomy; CRC cis rs13082711 0.911 rs3816881 chr3:27432888 T/C cg02860705 chr3:27208620 NA 0.6 8.69 0.43 1.69e-16 Systolic blood pressure;Diastolic blood pressure;Blood pressure; CRC trans rs7615952 0.932 rs7629977 chr3:125649573 T/G cg02007433 chr3:129722099 NA -0.44 -6.02 -0.31 4.6e-9 Blood pressure (smoking interaction); CRC cis rs8103278 1.000 rs35302007 chr19:46219145 G/C cg11657440 chr19:46296263 DMWD -0.49 -6.85 -0.35 3.61e-11 Coronary artery disease; CRC cis rs9467711 0.606 rs9393711 chr6:26370659 C/T cg14345882 chr6:26364793 BTN3A2 0.65 5.74 0.3 2.17e-8 Autism spectrum disorder or schizophrenia; CRC cis rs6840360 0.967 rs1511170 chr4:152701110 A/G cg09659197 chr4:152720779 NA 0.52 11.48 0.53 6.71e-26 Intelligence (multi-trait analysis); CRC cis rs4665809 0.818 rs35413760 chr2:26267137 C/A cg25036284 chr2:26402008 FAM59B 0.53 5.98 0.31 5.81e-9 Gut microbiome composition (summer); CRC cis rs6951245 0.580 rs77101766 chr7:1122438 A/G cg26224354 chr7:1096374 C7orf50;GPR146 -0.63 -8.39 -0.42 1.44e-15 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs9283706 0.608 rs12523505 chr5:66334631 C/T cg11590213 chr5:66331682 MAST4 0.4 5.62 0.3 4.06e-8 Coronary artery disease; CRC cis rs9300255 0.566 rs1716169 chr12:123716930 A/T cg00376283 chr12:123451042 ABCB9 0.56 6.51 0.34 2.88e-10 Neutrophil percentage of white cells; CRC cis rs3812762 0.879 rs10769959 chr11:8818833 G/A cg00186954 chr11:8933980 ST5;C11orf17 0.38 5.92 0.31 8.12e-9 Hypospadias; CRC cis rs3617 0.591 rs2276823 chr3:52869263 C/A cg15147215 chr3:52552868 STAB1 0.51 8.74 0.43 1.26e-16 Red blood cell count;Autism spectrum disorder or schizophrenia; CRC cis rs2050392 0.861 rs303448 chr10:30727084 G/T cg18806716 chr10:30721971 MAP3K8 -0.49 -7.42 -0.38 9.84e-13 Inflammatory bowel disease; CRC cis rs6502050 0.871 rs6502056 chr17:80070912 C/G cg09264619 chr17:80180166 NA 0.37 6.02 0.32 4.6e-9 Life satisfaction; CRC cis rs7927592 0.913 rs3758643 chr11:68367193 C/T cg01657329 chr11:68192670 LRP5 -0.48 -6.88 -0.35 3e-11 Total body bone mineral density; CRC cis rs9372498 0.536 rs62424175 chr6:118797381 T/A cg18833306 chr6:118973337 C6orf204 0.45 5.72 0.3 2.35e-8 Diastolic blood pressure; CRC cis rs7493 0.853 rs6973380 chr7:95043523 C/T cg20119798 chr7:94954144 PON1 -0.49 -6.43 -0.33 4.48e-10 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs35000415 0.938 rs17339836 chr7:128681062 C/T cg19972273 chr7:128594194 NA 0.68 6.25 0.33 1.27e-9 Systemic lupus erythematosus; CRC cis rs7312933 1.000 rs12372623 chr12:42531666 G/A cg01256987 chr12:42539512 GXYLT1 -0.42 -6.43 -0.33 4.42e-10 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CRC cis rs9296736 0.961 rs9370260 chr6:53921674 T/C cg04374786 chr6:53939321 C6orf142 0.45 7.21 0.37 3.97e-12 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs6860806 0.661 rs1588263 chr5:131577158 T/C cg02033258 chr5:131593261 PDLIM4 0.41 7.82 0.4 7.08e-14 Breast cancer; CRC cis rs2530545 0.619 rs6955901 chr7:34662400 C/T cg14401837 chr7:34697493 NPSR1 0.42 6.27 0.33 1.14e-9 IgG glycosylation; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg10325398 chr1:45476990 HECTD3;UROD 0.45 5.98 0.31 5.91e-9 Anxiety disorder; CRC cis rs6964587 1.000 rs12539231 chr7:91634963 G/A cg17063962 chr7:91808500 NA 0.8 14.24 0.62 3.57e-36 Breast cancer; CRC cis rs10512697 0.772 rs62336077 chr5:3516458 G/A cg19473799 chr5:3511975 NA -0.83 -6.34 -0.33 7.66e-10 Immune response to smallpox vaccine (IL-6); CRC cis rs447 1.000 rs2158566 chr7:83755276 A/C cg22846510 chr7:83753280 SEMA3A -0.61 -7.79 -0.39 8.85e-14 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs6459804 0.967 rs10233396 chr7:157512290 C/T cg05585630 chr7:157510462 PTPRN2 -0.39 -6.18 -0.32 1.91e-9 Bipolar disorder and schizophrenia; CRC cis rs1153858 1.000 rs3809472 chr15:45694318 G/T cg10760299 chr15:45669010 GATM 0.51 7.78 0.39 9.59e-14 Homoarginine levels; CRC trans rs2243480 0.706 rs6460257 chr7:65196780 C/T cg10756647 chr7:56101905 PSPH 0.66 7.83 0.4 6.57e-14 Diabetic kidney disease; CRC cis rs2120019 1.000 rs2083731 chr15:75368538 A/C cg09165964 chr15:75287851 SCAMP5 -0.79 -12.46 -0.57 1.82e-29 Blood trace element (Zn levels); CRC cis rs875971 1.000 rs6957199 chr7:65978519 T/C cg00343986 chr7:65444356 GUSB 0.44 6.47 0.34 3.52e-10 Aortic root size; CRC cis rs7113874 0.610 rs7947670 chr11:8525531 A/C cg02811074 chr11:8615871 STK33 -0.36 -6.22 -0.32 1.54e-9 Body mass index in physically active individuals;Body mass index (joint analysis main effects and physical activity interaction); CRC trans rs1814175 0.817 rs4881623 chr11:49804991 C/T cg15704280 chr7:45808275 SEPT13 -1.01 -20.35 -0.75 3.67e-60 Height; CRC cis rs9488822 0.676 rs12524249 chr6:116368813 G/A cg18764771 chr6:116381957 FRK 0.24 6.97 0.36 1.77e-11 Cholesterol, total;LDL cholesterol; CRC cis rs35110281 0.693 rs2251253 chr21:45092257 T/A cg04455712 chr21:45112962 RRP1B 0.42 8.32 0.42 2.39e-15 Mean corpuscular volume; CRC cis rs9462846 0.959 rs57514728 chr6:42860748 C/T cg10862848 chr6:42927986 GNMT -0.3 -5.64 -0.3 3.75e-8 Blood protein levels; CRC cis rs7917772 0.582 rs4917978 chr10:104366353 C/T cg11453585 chr10:104263688 ACTR1A;SUFU -0.83 -15.4 -0.65 1.13e-40 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg16128701 chr8:82193449 FABP5 0.4 6.41 0.33 5.01e-10 Liver disease severity in Alagille syndrome; CRC trans rs57221529 0.709 rs4957056 chr5:570105 T/C cg11887960 chr12:57824829 NA 0.6 6.68 0.35 1.01e-10 Lung disease severity in cystic fibrosis; CRC cis rs55665837 0.583 rs78843135 chr11:14411254 T/G cg19336497 chr11:14380999 RRAS2 -0.47 -8.1 -0.41 1.11e-14 Vitamin D levels; CRC cis rs3096299 0.685 rs12446145 chr16:89542695 C/T cg02187348 chr16:89574699 SPG7 0.4 5.94 0.31 7.29e-9 Multiple myeloma (IgH translocation); CRC cis rs10751667 1.000 rs7927156 chr11:970607 A/G cg23136738 chr11:925521 AP2A2 -0.45 -6.74 -0.35 7.19e-11 Alzheimer's disease (late onset); CRC cis rs9486715 1.000 rs9373985 chr6:97063522 C/G cg18709589 chr6:96969512 KIAA0776 -0.53 -7.64 -0.39 2.45e-13 Headache; CRC cis rs4631830 0.720 rs2843560 chr10:51512129 C/G cg20129853 chr10:51489980 NA 0.36 5.93 0.31 7.84e-9 Prostate-specific antigen levels; CRC cis rs908922 0.676 rs3753451 chr1:152485227 T/G cg23254163 chr1:152506842 NA 0.44 8.81 0.44 7.45e-17 Hair morphology; CRC cis rs9435341 0.929 rs1730865 chr1:107605611 A/C cg15468180 chr1:107600409 PRMT6 0.43 6.4 0.33 5.43e-10 Facial morphology (factor 21, depth of nasal alae); CRC cis rs9640161 0.659 rs17837498 chr7:150009679 A/G cg13722127 chr7:150037890 RARRES2 0.46 7.39 0.38 1.2e-12 Blood protein levels;Circulating chemerin levels; CRC cis rs1577917 0.958 rs12209259 chr6:86502348 T/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.52 -6.9 -0.36 2.74e-11 Response to antipsychotic treatment; CRC cis rs1832871 0.672 rs7750011 chr6:158746802 A/C cg07165851 chr6:158734300 TULP4 0.63 7.96 0.4 2.75e-14 Height; CRC cis rs11146838 1 rs11146838 chr10:39149977 A/T cg18963800 chr10:38644991 HSD17B7P2 -0.46 -6.62 -0.34 1.44e-10 Breast cancer; CRC cis rs4478858 0.684 rs11578407 chr1:31728543 A/G cg00250761 chr1:31883323 NA -0.41 -7.85 -0.4 5.83e-14 Alcohol dependence; CRC cis rs68170813 0.559 rs4730239 chr7:107056960 A/T cg02696742 chr7:106810147 HBP1 -0.57 -5.9 -0.31 8.9e-9 Coronary artery disease; CRC cis rs1878931 0.582 rs9921152 chr16:3421199 A/G cg26668626 chr16:3451006 ZNF174;ZNF434 0.57 7.08 0.36 8.83e-12 Body mass index (adult); CRC cis rs2249694 0.586 rs9418987 chr10:135324409 A/G cg20169779 chr10:135381914 SYCE1 0.63 9.64 0.47 1.51e-19 Obesity-related traits; CRC cis rs6951245 1.000 rs76129108 chr7:1089159 G/A cg26224354 chr7:1096374 C7orf50;GPR146 -0.94 -11.87 -0.55 2.79e-27 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs3749237 0.595 rs1464568 chr3:49458266 G/A cg03060546 chr3:49711283 APEH 0.65 11.05 0.52 2.41e-24 Resting heart rate; CRC cis rs6793245 0.960 rs7373779 chr3:38593943 T/C cg01465620 chr3:38496096 LOC100128640;ACVR2B -0.54 -7.88 -0.4 4.71e-14 QT interval; CRC cis rs1552244 1.000 rs9834980 chr3:10065528 G/A cg10729496 chr3:10149963 C3orf24 0.5 6.71 0.35 8.29e-11 Alzheimer's disease; CRC cis rs13256369 0.901 rs12681298 chr8:8566235 A/G cg18904891 chr8:8559673 CLDN23 -0.58 -8.38 -0.42 1.52e-15 Obesity-related traits; CRC cis rs4363385 0.740 rs1338181 chr1:153010301 C/T cg25856811 chr1:152973957 SPRR3 -0.25 -6.99 -0.36 1.51e-11 Inflammatory skin disease; CRC cis rs1799949 1.000 rs8176269 chr17:41213626 G/T cg01879757 chr17:41196368 BRCA1 -0.41 -6.11 -0.32 2.79e-9 Menopause (age at onset); CRC cis rs889398 0.769 rs12927052 chr16:69857043 A/G cg00738113 chr16:70207722 CLEC18C 0.33 5.62 0.3 4.04e-8 Body mass index; CRC cis rs7618501 0.633 rs4688755 chr3:50064424 G/A cg24308560 chr3:49941425 MST1R 0.5 8.14 0.41 8.11e-15 Intelligence (multi-trait analysis); CRC cis rs9486719 1.000 rs12208124 chr6:97027942 C/T cg06623918 chr6:96969491 KIAA0776 -0.82 -9.53 -0.47 3.58e-19 Migraine;Coronary artery disease; CRC cis rs10504229 0.512 rs117968470 chr8:58014651 C/G cg02290350 chr8:58132656 NA -0.51 -5.89 -0.31 9.42e-9 Developmental language disorder (linguistic errors); CRC trans rs10506458 0.834 rs73127067 chr12:63390333 G/T cg22491629 chr6:157744540 C6orf35 -0.73 -8.33 -0.42 2.18e-15 Hemostatic factors and hematological phenotypes; CRC cis rs2276314 0.802 rs58906216 chr18:33630297 T/C cg05985134 chr18:33552581 C18orf21 0.5 6.69 0.35 9.5e-11 Endometriosis;Drug-induced torsades de pointes; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg26376749 chr17:30677620 ZNF207 0.48 6.64 0.34 1.34e-10 Response to antipsychotic treatment; CRC cis rs9487051 0.676 rs9398196 chr6:109601554 A/G cg21918786 chr6:109611834 NA -0.4 -7.03 -0.36 1.21e-11 Reticulocyte fraction of red cells; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg22817719 chr11:130068300 ST14 -0.41 -6.98 -0.36 1.64e-11 Liver disease severity in Alagille syndrome; CRC cis rs7259376 0.777 rs7247735 chr19:22575488 C/T cg02657401 chr19:22469223 NA 0.31 6.78 0.35 5.73e-11 Menopause (age at onset); CRC trans rs1814175 0.817 rs4881627 chr11:49953955 C/A cg21153622 chr11:89784906 NA -0.37 -6.03 -0.32 4.33e-9 Height; CRC cis rs9902453 0.817 rs1842026 chr17:28188111 C/T cg26525008 chr17:28256777 EFCAB5;SSH2 0.57 8.69 0.43 1.78e-16 Coffee consumption (cups per day); CRC cis rs3736594 0.649 rs867282 chr2:27951658 A/G cg27432699 chr2:27873401 GPN1 -0.59 -8.01 -0.4 1.97e-14 Fasting blood glucose;Fasting blood glucose (BMI interaction); CRC cis rs2180341 0.960 rs1543432 chr6:127698018 T/C cg24812749 chr6:127587940 RNF146 0.97 13.51 0.6 2.11e-33 Breast cancer; CRC cis rs3857067 0.773 rs2865344 chr4:95103040 C/T cg11021082 chr4:95130006 SMARCAD1 -0.49 -7.61 -0.39 2.93e-13 QT interval; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg15398448 chr19:50353971 PTOV1 0.48 6.66 0.34 1.12e-10 Response to antipsychotic treatment; CRC cis rs758324 0.947 rs173812 chr5:131319460 A/G cg06307176 chr5:131281290 NA -0.37 -5.78 -0.3 1.72e-8 Alzheimer's disease in APOE e4- carriers; CRC cis rs7945705 0.967 rs7943377 chr11:8848700 C/T cg00186954 chr11:8933980 ST5;C11orf17 0.38 5.79 0.3 1.63e-8 Hemoglobin concentration; CRC cis rs875971 0.862 rs2088653 chr7:65808608 G/A cg18252515 chr7:66147081 NA 0.41 5.76 0.3 1.94e-8 Aortic root size; CRC cis rs669446 0.562 rs4660259 chr1:44194534 A/G cg12908607 chr1:44402522 ARTN -0.34 -5.91 -0.31 8.5e-9 Amyotrophic lateral sclerosis (age of onset); CRC cis rs372883 0.648 rs368322 chr21:30717151 C/T cg08807101 chr21:30365312 RNF160 -0.52 -7.41 -0.38 1.08e-12 Pancreatic cancer; CRC cis rs6088590 0.965 rs13040449 chr20:33358901 T/A cg08999081 chr20:33150536 PIGU 0.52 8.58 0.43 3.92e-16 Coronary artery disease; CRC cis rs13063635 0.831 rs36040135 chr3:46061304 A/G cg12691230 chr3:46064611 XCR1 -0.53 -5.77 -0.3 1.83e-8 Eosinophil percentage of granulocytes; CRC cis rs12477438 0.520 rs7605843 chr2:99811894 C/T cg14399236 chr2:99771627 LIPT1;TSGA10 0.76 13.22 0.59 2.65e-32 Chronic sinus infection; CRC cis rs832540 0.556 rs4146565 chr5:56093825 T/C cg18230493 chr5:56204884 C5orf35 -0.4 -5.77 -0.3 1.86e-8 Coronary artery disease; CRC cis rs68170813 0.559 rs7783181 chr7:106977613 A/G cg02696742 chr7:106810147 HBP1 -0.52 -6.04 -0.32 4.15e-9 Coronary artery disease; CRC cis rs10540 1.000 rs61877760 chr11:506596 C/T cg03576123 chr11:487126 PTDSS2 -1.04 -10.73 -0.51 3.15e-23 Body mass index; CRC trans rs1997103 1.000 rs4947501 chr7:55407342 C/T cg20935933 chr6:143382018 AIG1 0.51 6.65 0.34 1.25e-10 QRS interval (sulfonylurea treatment interaction); CRC cis rs1552244 1.000 rs55882090 chr3:10139082 C/T cg18598329 chr3:10140678 FANCD2;C3orf24 -0.9 -13.24 -0.59 2.25e-32 Alzheimer's disease; CRC cis rs7618915 0.571 rs1961959 chr3:52585760 G/C cg07507251 chr3:52567010 NT5DC2 0.46 6.71 0.35 8.61e-11 Bipolar disorder; CRC cis rs644799 0.511 rs10831420 chr11:95478209 T/C cg03916912 chr11:95522834 CEP57;FAM76B 0.66 9.92 0.48 1.81e-20 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs9372498 0.536 rs9489395 chr6:118758884 T/C cg15382696 chr6:118971807 C6orf204 0.6 7.67 0.39 1.9e-13 Diastolic blood pressure; CRC cis rs11583043 1.000 rs34915449 chr1:101476786 G/A cg16556008 chr1:101360663 SLC30A7;EXTL2 0.45 5.68 0.3 3.01e-8 Ulcerative colitis;Inflammatory bowel disease; CRC cis rs1030268 0.667 rs12707111 chr7:133330144 C/T cg10665199 chr7:133106180 EXOC4 0.64 7.73 0.39 1.32e-13 Intelligence (multi-trait analysis); CRC cis rs853679 0.517 rs9368555 chr6:28108967 T/C cg15786705 chr6:28176104 NA 0.78 9.83 0.48 3.57e-20 Depression; CRC cis rs9894429 1.000 rs7209180 chr17:79581519 C/A cg13777783 chr17:79615861 NA -0.3 -5.72 -0.3 2.44e-8 Eye color traits; CRC cis rs9916302 0.904 rs9898773 chr17:37532507 C/G cg03013999 chr17:37608204 MED1 -0.47 -7.31 -0.37 2.09e-12 Glomerular filtration rate (creatinine); CRC trans rs4478147 0.591 rs56009992 chr4:87459669 G/A cg01215037 chr19:50083917 PRRG2;NOSIP 0.49 6.46 0.34 3.68e-10 Migraine - clinic-based; CRC cis rs1552244 0.882 rs55808392 chr3:10054681 C/T cg10729496 chr3:10149963 C3orf24 0.49 6.31 0.33 9.2e-10 Alzheimer's disease; CRC cis rs12541635 0.677 rs7846149 chr8:107053417 T/C cg10147462 chr8:107024639 NA 0.61 11.08 0.52 1.93e-24 Age of smoking initiation; CRC cis rs12760731 0.720 rs10913560 chr1:178452629 A/G cg00404053 chr1:178313656 RASAL2 1.06 11.12 0.52 1.37e-24 Obesity-related traits; CRC cis rs873946 0.586 rs12767391 chr10:134573844 A/G cg27286337 chr10:134555280 INPP5A -0.78 -9.65 -0.47 1.46e-19 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CRC cis rs919433 0.713 rs2045245 chr2:198485341 A/C cg10820045 chr2:198174542 NA 0.41 7.01 0.36 1.33e-11 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC cis rs2477686 0.526 rs2477690 chr1:2395563 G/A cg07700843 chr1:2391317 NA -0.49 -7.7 -0.39 1.62e-13 Non-obstructive azoospermia; CRC cis rs1223397 0.938 rs3817737 chr6:13279082 A/G cg06879394 chr6:13274151 PHACTR1 0.51 6.03 0.32 4.38e-9 Blood pressure; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg16901519 chr22:18560646 PEX26 0.35 6.1 0.32 3.04e-9 Liver disease severity in Alagille syndrome; CRC cis rs881375 0.900 rs1930786 chr9:123691469 C/G cg09586646 chr9:123605570 PSMD5;LOC253039 0.48 6.55 0.34 2.28e-10 Rheumatoid arthritis; CRC cis rs1018836 0.923 rs13277387 chr8:91633713 C/G cg16814680 chr8:91681699 NA -0.69 -10.61 -0.51 7.96e-23 Ejection fraction in Tripanosoma cruzi seropositivity; CRC cis rs769267 0.965 rs2905425 chr19:19475717 G/C cg17414380 chr19:19431394 KIAA0892;SF4 -0.42 -5.72 -0.3 2.4e-8 Tonsillectomy; CRC cis rs600231 0.665 rs1621277 chr11:65221954 A/G cg17120908 chr11:65337727 SSSCA1 0.55 7.92 0.4 3.63e-14 Bone mineral density; CRC cis rs1403694 0.695 rs1836860 chr3:186436604 C/T cg04611788 chr3:186434169 KNG1 0.59 8.76 0.44 1.03e-16 Blood protein levels; CRC cis rs10504229 1.000 rs60651159 chr8:58174074 T/C cg05313129 chr8:58192883 C8orf71 -0.47 -6.99 -0.36 1.49e-11 Developmental language disorder (linguistic errors); CRC cis rs7833790 0.654 rs7835342 chr8:82698092 A/G cg17211192 chr8:82754475 SNX16 -0.46 -6.17 -0.32 1.98e-9 Diastolic blood pressure; CRC cis rs9487051 0.676 rs6568566 chr6:109596792 G/A cg12927641 chr6:109611667 NA -0.36 -6.44 -0.33 4.15e-10 Reticulocyte fraction of red cells; CRC cis rs7937682 0.575 rs34695265 chr11:111719128 T/C cg19812747 chr11:111475976 SIK2 0.45 6.68 0.35 1.04e-10 Primary sclerosing cholangitis; CRC trans rs10983614 1.000 rs7867776 chr9:120072627 A/G cg26706201 chr11:57103334 SSRP1 0.43 5.96 0.31 6.52e-9 Survival in pancreatic cancer; CRC cis rs4908768 0.501 rs1463051 chr1:8596893 A/T cg20416874 chr1:8611966 RERE 0.43 6.27 0.33 1.13e-9 Neuroticism (multi-trait analysis);Subjective well-being (multi-trait analysis); CRC cis rs12451471 0.637 rs12452616 chr17:78090081 A/G cg08347473 chr17:78092826 GAA 0.35 6.04 0.32 4.11e-9 Plateletcrit;Mean corpuscular hemoglobin concentration; CRC cis rs2204008 0.744 rs11168870 chr12:37973333 A/G cg26384229 chr12:38710491 ALG10B 0.69 9.14 0.45 6.75e-18 Bladder cancer; CRC cis rs189798 0.592 rs10111263 chr8:8969433 C/G cg06636001 chr8:8085503 FLJ10661 -0.52 -7.55 -0.38 4.24e-13 Myopia (pathological); CRC cis rs262150 0.544 rs2428780 chr7:158812471 T/A cg10570241 chr7:158785291 NA 0.38 6.54 0.34 2.29e-10 Facial morphology (factor 20); CRC cis rs155076 1.000 rs566364 chr13:21837583 T/C cg21970626 chr13:21893289 NA 0.46 5.94 0.31 7.09e-9 White matter hyperintensity burden; CRC cis rs6502050 0.835 rs7406529 chr17:80080877 C/T cg19223190 chr17:80058835 NA -0.39 -6.22 -0.32 1.52e-9 Life satisfaction; CRC trans rs2243480 1.000 rs35542501 chr7:65431215 T/C cg10756647 chr7:56101905 PSPH 0.73 8.14 0.41 8.01e-15 Diabetic kidney disease; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg12277888 chr11:35723985 TRIM44 -0.41 -6.71 -0.35 8.67e-11 Liver disease severity in Alagille syndrome; CRC trans rs783540 0.846 rs2099259 chr15:83323688 C/T cg18393722 chr15:85113863 UBE2QP1 0.37 6.49 0.34 3.11e-10 Schizophrenia; CRC cis rs7647973 0.580 rs12637576 chr3:49237334 C/T cg07636037 chr3:49044803 WDR6 0.82 12.37 0.56 4.11e-29 Menarche (age at onset); CRC cis rs9487051 0.768 rs398944 chr6:109523444 T/G cg01475377 chr6:109611718 NA -0.34 -5.81 -0.31 1.45e-8 Reticulocyte fraction of red cells; CRC cis rs8180040 0.932 rs12489046 chr3:47527683 T/G cg10298567 chr3:47292165 KIF9 -0.36 -5.91 -0.31 8.57e-9 Colorectal cancer; CRC cis rs4713118 0.513 rs9368547 chr6:28028067 A/G cg06470822 chr6:28175283 NA 0.82 12.11 0.56 3.71e-28 Parkinson's disease; CRC cis rs698833 0.859 rs17580340 chr2:44602554 C/G cg04920474 chr2:44395004 PPM1B 0.41 6.14 0.32 2.35e-9 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; CRC cis rs1799949 1.000 rs11651341 chr17:41428061 T/C cg05368731 chr17:41323189 NBR1 0.66 9.98 0.48 1.19e-20 Menopause (age at onset); CRC trans rs16846053 0.786 rs115562071 chr2:162493241 C/T cg12500891 chr11:57225987 NA -0.69 -6.13 -0.32 2.48e-9 Blood osmolality (transformed sodium); CRC cis rs9435341 0.965 rs3108680 chr1:107572997 T/C cg15468180 chr1:107600409 PRMT6 0.35 5.61 0.3 4.38e-8 Facial morphology (factor 21, depth of nasal alae); CRC cis rs881375 0.933 rs7021206 chr9:123684157 A/G cg09419670 chr9:123605666 PSMD5;LOC253039 -0.54 -7.81 -0.4 7.74e-14 Rheumatoid arthritis; CRC cis rs734999 0.549 rs2764845 chr1:2528999 G/T cg20673091 chr1:2541236 MMEL1 -0.36 -5.82 -0.31 1.39e-8 Ulcerative colitis; CRC cis rs10512697 0.685 rs11741304 chr5:3577245 C/T cg19473799 chr5:3511975 NA -0.73 -5.8 -0.3 1.53e-8 Immune response to smallpox vaccine (IL-6); CRC cis rs13118159 0.836 rs2276903 chr4:1343405 A/G cg23123621 chr4:1343375 KIAA1530 0.38 6.72 0.35 8.1e-11 Longevity; CRC cis rs8170 1.000 rs61634114 chr19:17387254 G/A cg04749549 chr19:17459798 NA -0.42 -5.63 -0.3 3.77e-8 Breast cancer (estrogen-receptor negative);Breast Cancer in BRCA1 mutation carriers;Ovarian cancer;Breast cancer;Epithelial ovarian cancer; CRC trans rs2727020 0.563 rs10769582 chr11:49474040 T/C cg21153622 chr11:89784906 NA -0.37 -5.99 -0.31 5.44e-9 Coronary artery disease; CRC cis rs6840360 1.000 rs6840360 chr4:152604031 C/T cg09659197 chr4:152720779 NA 0.51 10.57 0.5 1.12e-22 Intelligence (multi-trait analysis); CRC cis rs736408 0.561 rs2276815 chr3:52853747 C/G cg18404041 chr3:52824283 ITIH1 -0.4 -7.36 -0.38 1.48e-12 Bipolar disorder; CRC cis rs12410462 0.748 rs1495853 chr1:227657336 A/G cg23173402 chr1:227635558 NA -0.58 -6.72 -0.35 7.93e-11 Major depressive disorder; CRC cis rs2075371 0.796 rs12154724 chr7:133943443 G/A cg20476274 chr7:133979776 SLC35B4 0.71 11.56 0.54 3.64e-26 Mean platelet volume; CRC trans rs2821260 0.902 rs12131816 chr1:72529866 A/G cg01575614 chr17:40169693 DNAJC7;NKIRAS2 -0.49 -5.96 -0.31 6.49e-9 Intelligence (multi-trait analysis); CRC cis rs7772486 0.597 rs6912351 chr6:146264071 T/C cg13319975 chr6:146136371 FBXO30 0.64 9.29 0.46 2.09e-18 Lobe attachment (rater-scored or self-reported); CRC cis rs7215564 0.908 rs2316060 chr17:78663728 T/C cg09596252 chr17:78655493 RPTOR 0.56 6.11 0.32 2.76e-9 Myopia (pathological); CRC cis rs3617 0.539 rs9825369 chr3:52953311 T/C cg07507251 chr3:52567010 NT5DC2 -0.37 -5.61 -0.3 4.28e-8 Red blood cell count;Autism spectrum disorder or schizophrenia; CRC cis rs2832077 0.527 rs9981922 chr21:30212718 A/G cg24692254 chr21:30365293 RNF160 -0.45 -6.77 -0.35 6.01e-11 Cognitive test performance; CRC cis rs6681460 0.932 rs2146904 chr1:67160336 C/T cg02459107 chr1:67143332 SGIP1 -0.4 -6.76 -0.35 6.3e-11 Presence of antiphospholipid antibodies; CRC cis rs3858526 0.606 rs10838883 chr11:5952147 G/A cg05234568 chr11:5960015 NA 0.72 12.57 0.57 7.07e-30 DNA methylation (variation); CRC cis rs6502050 0.528 rs12942561 chr17:80116639 G/A cg25804541 chr17:80189381 SLC16A3 -0.31 -6.06 -0.32 3.74e-9 Life satisfaction; CRC cis rs2073300 0.609 rs6137917 chr20:23360369 G/A cg12062639 chr20:23401060 NAPB 0.71 6.48 0.34 3.37e-10 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs3812049 0.826 rs2409110 chr5:127433047 A/T cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.73 8.99 0.44 2.03e-17 Lymphocyte counts;Red cell distribution width; CRC cis rs11809207 0.523 rs2186232 chr1:26502676 T/A cg23602478 chr1:26503979 CNKSR1 0.25 5.67 0.3 3.19e-8 Height; CRC cis rs6860806 0.507 rs2631362 chr5:131707293 A/G cg22638593 chr5:131593259 PDLIM4 -0.39 -6.46 -0.34 3.69e-10 Breast cancer; CRC cis rs6951245 1.000 rs11767527 chr7:1097394 T/C cg24642844 chr7:1081250 C7orf50 -0.76 -9.16 -0.45 5.78e-18 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs2580764 0.565 rs7562292 chr2:55230219 C/T cg09592903 chr2:55203963 RTN4 -0.74 -12.01 -0.55 8.16e-28 Mean platelet volume; CRC cis rs734999 0.545 rs10797436 chr1:2538349 G/A cg20673091 chr1:2541236 MMEL1 0.37 5.88 0.31 1.03e-8 Ulcerative colitis; CRC cis rs9894429 0.752 rs6565610 chr17:79592652 A/G cg21028142 chr17:79581711 NPLOC4 0.33 6.97 0.36 1.77e-11 Eye color traits; CRC cis rs10504229 0.683 rs55660024 chr8:58128943 G/A cg05313129 chr8:58192883 C8orf71 -0.43 -6.11 -0.32 2.74e-9 Developmental language disorder (linguistic errors); CRC cis rs10883723 0.810 rs7090034 chr10:104281155 C/G cg22532475 chr10:104410764 TRIM8 -0.36 -6.79 -0.35 5.16e-11 Allergic disease (asthma, hay fever or eczema); CRC cis rs2404602 0.575 rs11072611 chr15:76947983 A/G cg23625390 chr15:77176239 SCAPER 0.75 11.01 0.52 3.39e-24 Blood metabolite levels; CRC cis rs7666738 0.753 rs34164013 chr4:98976333 A/G cg17366294 chr4:99064904 C4orf37 0.44 7.44 0.38 8.98e-13 Colonoscopy-negative controls vs population controls; CRC cis rs2223471 0.727 rs2206272 chr6:50765352 C/T cg03432817 chr6:50765336 NA -0.42 -6.81 -0.35 4.69e-11 Subcutaneous adipose tissue; CRC cis rs6951245 0.872 rs74360401 chr7:1067403 G/A cg18402987 chr7:1209562 NA 0.64 6.77 0.35 6.03e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs9633740 0.545 rs2343306 chr10:82230146 A/G cg00277334 chr10:82204260 NA 0.57 6.89 0.36 2.77e-11 Post bronchodilator FEV1; CRC cis rs9768139 1.000 rs9768139 chr7:158120731 G/A cg25566285 chr7:158114605 PTPRN2 -0.58 -9.91 -0.48 1.95e-20 Calcium levels; CRC cis rs7618915 0.547 rs4687548 chr3:52666650 A/T cg10802521 chr3:52805072 NEK4 -0.58 -8.96 -0.44 2.53e-17 Bipolar disorder; CRC cis rs6502050 0.787 rs7222326 chr17:80057272 T/C cg13198984 chr17:80129470 CCDC57 -0.39 -6.54 -0.34 2.32e-10 Life satisfaction; CRC cis rs3772130 0.962 rs9848027 chr3:121551227 T/C cg20356878 chr3:121714668 ILDR1 0.52 8.05 0.41 1.49e-14 Cognitive performance; CRC cis rs10504229 0.683 rs11774847 chr8:58140775 T/A cg11062466 chr8:58055876 NA 0.57 7.05 0.36 1.04e-11 Developmental language disorder (linguistic errors); CRC cis rs13256369 1.000 rs12550458 chr8:8567832 G/A cg06671706 chr8:8559999 CLDN23 0.62 9.14 0.45 6.71e-18 Obesity-related traits; CRC cis rs6502050 0.769 rs9898292 chr17:80100345 A/T cg13198984 chr17:80129470 CCDC57 0.46 8.16 0.41 6.94e-15 Life satisfaction; CRC cis rs1008375 1.000 rs28501187 chr4:17643620 G/A cg04450456 chr4:17643702 FAM184B 0.4 6.51 0.34 2.81e-10 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs2032447 1.000 rs2032447 chr6:26044369 A/G cg18357526 chr6:26021779 HIST1H4A 0.72 11.2 0.53 6.82e-25 Intelligence (multi-trait analysis); CRC cis rs1838105 0.556 rs34710835 chr17:45146717 C/T cg16759221 chr17:45003025 GOSR2 0.52 8.07 0.41 1.32e-14 Nonsyndromic cleft lip with cleft palate; CRC cis rs1552244 0.882 rs7633769 chr3:10020622 C/T cg13047869 chr3:10149882 C3orf24 0.48 6.78 0.35 5.47e-11 Alzheimer's disease; CRC cis rs9300255 0.544 rs1727309 chr12:123658258 A/G cg00376283 chr12:123451042 ABCB9 0.58 6.79 0.35 5.15e-11 Neutrophil percentage of white cells; CRC cis rs11098499 0.708 rs11732686 chr4:120252330 C/A cg09307838 chr4:120376055 NA 0.61 9.59 0.47 2.22e-19 Corneal astigmatism; CRC trans rs2303319 0.504 rs62189046 chr2:162612371 C/G cg14875682 chr5:52083620 ITGA1;PELO -0.73 -6.16 -0.32 2.11e-9 Cognitive function; CRC trans rs951252 0.504 rs11734405 chr4:146081096 C/T cg21956150 chr19:1438388 RPS15 0.46 6.03 0.32 4.52e-9 Hip circumference; CRC cis rs2153535 0.542 rs1120393 chr6:8486890 G/A cg07606381 chr6:8435919 SLC35B3 0.67 10.69 0.51 4.33e-23 Motion sickness; CRC cis rs2032447 0.765 rs1935235 chr6:26067782 C/G cg26028573 chr6:26043587 HIST1H2BB 0.46 6.68 0.35 1.04e-10 Intelligence (multi-trait analysis); CRC cis rs6502050 0.842 rs9894129 chr17:80075700 A/G cg02741985 chr17:80059408 CCDC57 -0.45 -7.4 -0.38 1.17e-12 Life satisfaction; CRC cis rs60871478 1.000 rs7795258 chr7:795227 A/G cg04727924 chr7:799746 HEATR2 -0.43 -6.41 -0.33 5.01e-10 Cerebrospinal P-tau181p levels; CRC cis rs2274471 0.699 rs10974985 chr9:5156061 C/T cg03390472 chr9:5043263 JAK2 0.53 5.73 0.3 2.31e-8 Crohn's disease; CRC cis rs6893300 0.524 rs12522926 chr5:179214818 G/A cg14593053 chr5:179126677 CANX 0.52 8.36 0.42 1.76e-15 Resting heart rate; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg14877741 chr9:125703099 RABGAP1 0.43 6.0 0.31 5.3e-9 Response to antipsychotic treatment; CRC cis rs769267 0.965 rs2315025 chr19:19426609 C/T cg01262667 chr19:19385393 TM6SF2 0.38 6.22 0.32 1.5e-9 Tonsillectomy; CRC trans rs561341 1.000 rs7216102 chr17:30259450 A/G cg20587970 chr11:113659929 NA -0.98 -14.4 -0.62 8.87e-37 Hip circumference adjusted for BMI; CRC cis rs9486719 1.000 rs12210146 chr6:96903962 A/G cg06623918 chr6:96969491 KIAA0776 0.8 9.31 0.46 1.9e-18 Migraine;Coronary artery disease; CRC cis rs2979489 0.786 rs62508366 chr8:30369499 G/A cg26383811 chr8:30366931 RBPMS -0.73 -10.88 -0.51 9.4e-24 Mean corpuscular hemoglobin;Plateletcrit;Neutrophil count;Granulocyte count;Sum basophil neutrophil counts;Mean corpuscular volume;Myeloid white cell count;Sum neutrophil eosinophil counts; CRC cis rs10504229 0.906 rs6990615 chr8:58182956 G/A cg02725872 chr8:58115012 NA -0.38 -6.43 -0.33 4.44e-10 Developmental language disorder (linguistic errors); CRC cis rs7827545 1.000 rs4909911 chr8:135565255 G/A cg07299736 chr8:135490787 ZFAT -0.38 -6.19 -0.32 1.82e-9 Hypertension (SNP x SNP interaction); CRC cis rs1799949 0.965 rs4793234 chr17:41436183 A/G cg23758822 chr17:41437982 NA 0.79 13.25 0.59 2.13e-32 Menopause (age at onset); CRC cis rs6484504 0.576 rs2447671 chr11:31334323 A/G cg14844989 chr11:31128820 NA -0.34 -6.14 -0.32 2.33e-9 Red blood cell count; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg16836995 chr17:43662488 NA 0.49 6.16 0.32 2.07e-9 Thyroid stimulating hormone; CRC trans rs916888 0.610 rs199442 chr17:44820122 G/A cg01341218 chr17:43662625 NA 0.62 7.69 0.39 1.67e-13 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs35306767 0.714 rs67205460 chr10:1090366 C/T cg26597838 chr10:835615 NA 0.82 9.46 0.46 6.06e-19 Eosinophil percentage of granulocytes; CRC cis rs2797160 1.000 rs4897153 chr6:126003403 A/G cg05901451 chr6:126070800 HEY2 -0.41 -6.21 -0.32 1.61e-9 Endometrial cancer; CRC cis rs4713118 0.824 rs7759217 chr6:27730463 A/G cg20933634 chr6:27740509 NA 0.64 9.13 0.45 7.25e-18 Parkinson's disease; CRC trans rs4332037 0.722 rs60346318 chr7:1915824 C/G cg11693508 chr17:37793320 STARD3 0.57 7.08 0.36 8.78e-12 Bipolar disorder; CRC cis rs863345 0.565 rs12403685 chr1:158452399 C/T cg12129480 chr1:158549410 OR10X1 0.29 6.04 0.32 4.2e-9 Pneumococcal bacteremia; CRC trans rs3942852 0.774 rs1039481 chr11:48182237 G/A cg03929089 chr4:120376271 NA -0.72 -9.05 -0.45 1.27e-17 Acute lymphoblastic leukemia (childhood); CRC cis rs896854 0.654 rs13274945 chr8:95986626 C/T cg13393036 chr8:95962371 TP53INP1 -0.52 -8.91 -0.44 3.58e-17 Type 2 diabetes; CRC trans rs7824557 0.606 rs1435277 chr8:11196970 C/T cg06636001 chr8:8085503 FLJ10661 0.49 7.26 0.37 2.79e-12 Retinal vascular caliber; CRC cis rs7044106 0.537 rs4434680 chr9:123489688 A/G cg09586646 chr9:123605570 PSMD5;LOC253039 0.7 8.98 0.44 2.09e-17 Hip circumference adjusted for BMI; CRC trans rs6762477 0.748 rs2073726 chr3:50223593 T/A cg21659725 chr3:3221576 CRBN -0.43 -6.62 -0.34 1.5e-10 Menarche (age at onset); CRC cis rs7538876 1.000 rs4920603 chr1:17727379 C/G cg07965774 chr1:17746286 RCC2 -0.33 -6.41 -0.33 5.18e-10 Basal cell carcinoma; CRC cis rs4737010 0.501 rs2111805 chr8:41643457 G/C cg17182837 chr8:41585554 ANK1 -0.52 -6.91 -0.36 2.54e-11 Lymphocyte counts;High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Reticulocyte count;Reticulocyte fraction of red cells;Mean corpuscular volume;Immature fraction of reticulocytes;Mean corpuscular hemoglobin concentration; CRC cis rs875971 0.862 rs10282433 chr7:65721439 G/A cg18876405 chr7:65276391 NA -0.49 -8.04 -0.41 1.66e-14 Aortic root size; CRC trans rs2727020 0.612 rs603672 chr11:49234566 T/A cg21153622 chr11:89784906 NA 0.4 6.5 0.34 2.91e-10 Coronary artery disease; CRC cis rs7258465 1.000 rs7258465 chr19:18533642 A/G cg01065977 chr19:18549689 ISYNA1 -0.39 -6.08 -0.32 3.34e-9 Breast cancer; CRC trans rs2710642 0.962 rs2058567 chr2:63091426 T/C cg05376469 chr2:102649931 NA -0.38 -6.28 -0.33 1.09e-9 LDL cholesterol levels;LDL cholesterol; CRC cis rs798554 1.000 rs798545 chr7:2762386 C/T cg17321639 chr7:2759063 NA -0.55 -7.79 -0.39 8.65e-14 Height; CRC cis rs4975616 0.836 rs421629 chr5:1320136 G/A cg06550200 chr5:1325588 CLPTM1L -0.7 -10.84 -0.51 1.31e-23 Lung cancer; CRC cis rs4555082 0.874 rs2816621 chr14:105732762 A/T cg13114125 chr14:105738426 BRF1 -0.81 -11.74 -0.54 7.83e-27 Mean platelet volume;Platelet distribution width; CRC cis rs992157 0.717 rs11692780 chr2:219149163 A/G cg13835894 chr2:219148914 PNKD;TMBIM1 -0.37 -7.0 -0.36 1.42e-11 Colorectal cancer; CRC cis rs77972916 0.505 rs11899984 chr2:43578246 C/A cg06169590 chr2:43455088 ZFP36L2;LOC100129726 -0.59 -6.86 -0.35 3.36e-11 Granulocyte percentage of myeloid white cells; CRC cis rs10782582 0.609 rs6656501 chr1:76266126 A/C cg10523679 chr1:76189770 ACADM -0.4 -5.7 -0.3 2.7e-8 Daytime sleep phenotypes; CRC cis rs13315871 1.000 rs11708590 chr3:58336635 A/G cg20936604 chr3:58311152 NA 0.71 6.64 0.34 1.29e-10 Cholesterol, total; CRC cis rs2777491 0.915 rs28526381 chr15:41621842 A/C cg18705301 chr15:41695430 NDUFAF1 -0.69 -11.44 -0.53 9.35e-26 Ulcerative colitis; CRC cis rs1552244 0.816 rs9847657 chr3:10173492 G/T cg08888203 chr3:10149979 C3orf24 0.58 8.44 0.42 1.03e-15 Alzheimer's disease; CRC cis rs4926298 0.926 rs8111617 chr19:13191461 C/T cg04657146 chr19:12876947 HOOK2 -0.44 -5.89 -0.31 9.56e-9 Bipolar disorder; CRC cis rs13631 0.697 rs1018330 chr9:139980385 A/C cg04545659 chr9:139973827 UAP1L1 0.49 8.14 0.41 8.38e-15 Cerebrospinal fluid biomarker levels; CRC cis rs2302190 0.882 rs12942018 chr17:56613277 C/T cg12560992 chr17:57184187 TRIM37 0.51 5.99 0.31 5.48e-9 Vitamin D levels; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg00983485 chr15:31284262 MTMR10 0.44 6.35 0.33 7.21e-10 Response to antipsychotic treatment; CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg14090510 chr7:64839023 ZNF92 0.39 6.29 0.33 1.02e-9 Obesity-related traits; CRC trans rs561341 1.000 rs7214017 chr17:30332220 T/C cg27661571 chr11:113659931 NA -0.78 -9.61 -0.47 1.89e-19 Hip circumference adjusted for BMI; CRC cis rs294883 0.858 rs4708818 chr6:159723503 C/G cg14500486 chr6:159655392 FNDC1 0.35 5.81 0.31 1.44e-8 Coronary artery disease; CRC cis rs2857891 0.817 rs2638094 chr11:6981488 A/G cg04053776 chr11:6947353 ZNF215 0.5 6.63 0.34 1.34e-10 Response to cytadine analogues (cytosine arabinoside); CRC cis rs55788414 0.872 rs12102958 chr16:81186207 T/A cg06400318 chr16:81190750 PKD1L2 -0.61 -7.13 -0.37 6.35e-12 Left ventricular obstructive tract defect (maternal effect); CRC cis rs875971 0.929 rs6970860 chr7:65976634 A/G cg11764359 chr7:65958608 NA 0.63 10.25 0.49 1.39e-21 Aortic root size; CRC cis rs9925964 0.933 rs10871454 chr16:31048079 C/T cg02466173 chr16:30829666 NA 0.44 5.96 0.31 6.65e-9 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs6938 0.596 rs11072511 chr15:75159433 A/G cg09165964 chr15:75287851 SCAMP5 0.56 8.89 0.44 4.11e-17 Breast cancer; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg01038479 chr17:35767307 TADA2A;ACACA 0.47 6.81 0.35 4.74e-11 Intelligence (multi-trait analysis); CRC cis rs853679 0.517 rs9283884 chr6:28135660 C/G cg23161317 chr6:28129485 ZNF389 -0.5 -6.01 -0.31 5e-9 Depression; CRC cis rs6500602 0.826 rs7205189 chr16:4460114 A/G cg08645402 chr16:4508243 NA 0.55 7.67 0.39 2e-13 Schizophrenia; CRC trans rs1997103 1.000 rs4947499 chr7:55407196 T/C cg20935933 chr6:143382018 AIG1 0.51 6.65 0.34 1.25e-10 QRS interval (sulfonylurea treatment interaction); CRC cis rs250677 0.652 rs36045 chr5:148441184 A/G cg18129178 chr5:148520854 ABLIM3 0.4 5.91 0.31 8.33e-9 Breast cancer; CRC cis rs6700896 0.931 rs2889195 chr1:66156730 C/T cg04111102 chr1:66153794 NA 0.32 5.68 0.3 2.92e-8 C-reactive protein;Mean corpuscular volume;Mean corpuscular hemoglobin; CRC cis rs875971 0.660 rs801217 chr7:66010577 C/T cg00343986 chr7:65444356 GUSB -0.5 -7.44 -0.38 8.9e-13 Aortic root size; CRC cis rs17270561 0.609 rs9393658 chr6:25730438 C/T cg16482183 chr6:26056742 HIST1H1C 0.83 10.58 0.5 1.07e-22 Iron status biomarkers; CRC cis rs7914558 1.000 rs10786740 chr10:104935593 G/C cg04362960 chr10:104952993 NT5C2 0.59 8.71 0.43 1.46e-16 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs4132509 1.000 rs10927076 chr1:243958293 A/G cg21452805 chr1:244014465 NA 0.53 6.27 0.33 1.14e-9 RR interval (heart rate); CRC cis rs12477438 0.700 rs12467679 chr2:99654449 G/A cg26064155 chr2:99771622 LIPT1;TSGA10 -0.77 -10.95 -0.52 5.49e-24 Chronic sinus infection; CRC cis rs6762 0.748 rs7929032 chr11:839078 G/A cg03885332 chr11:832357 CD151 -0.42 -6.23 -0.32 1.46e-9 Mean platelet volume; CRC cis rs10256972 0.685 rs10263665 chr7:1110628 A/G cg03188948 chr7:1209495 NA 0.4 5.82 0.31 1.41e-8 Longevity;Endometriosis; CRC cis rs4654899 0.827 rs12564330 chr1:21207495 A/C cg02927042 chr1:21476669 EIF4G3 0.4 6.48 0.34 3.39e-10 Superior frontal gyrus grey matter volume; CRC cis rs34172651 0.502 rs12930727 chr16:24838497 G/T cg00339695 chr16:24857497 SLC5A11 -0.29 -6.82 -0.35 4.29e-11 Intelligence (multi-trait analysis); CRC cis rs7208859 0.673 rs61348930 chr17:29221763 C/T cg14008862 chr17:28927542 LRRC37B2 0.55 5.75 0.3 2.04e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs7927592 0.763 rs7120876 chr11:68261398 C/G cg01657329 chr11:68192670 LRP5 -0.53 -8.74 -0.43 1.18e-16 Total body bone mineral density; CRC cis rs9322193 0.923 rs12174716 chr6:149965623 C/T cg00933542 chr6:150070202 PCMT1 0.29 6.06 0.32 3.68e-9 Lung cancer; CRC cis rs1552244 0.882 rs9757159 chr3:10039166 C/T cg02579736 chr3:10068473 FANCD2;CIDECP 0.93 12.04 0.55 6.69e-28 Alzheimer's disease; CRC cis rs11166927 1.000 rs11778622 chr8:140805582 A/G cg16909799 chr8:140841666 TRAPPC9 0.39 5.95 0.31 6.98e-9 Pediatric non-alcoholic fatty liver disease activity score; CRC cis rs2836950 0.565 rs4816617 chr21:40540690 T/C cg06238570 chr21:40685208 BRWD1 -0.6 -8.88 -0.44 4.32e-17 Menarche (age at onset); CRC cis rs4713118 0.869 rs9283880 chr6:27715243 A/C cg15845792 chr6:28175446 NA 0.66 9.22 0.45 3.55e-18 Parkinson's disease; CRC cis rs2370759 1.000 rs78959390 chr10:32616346 C/T cg01819863 chr10:32635814 EPC1 1.1 13.26 0.59 1.87e-32 Sexual dysfunction (female); CRC cis rs1552244 1.000 rs6781811 chr3:10121922 A/G cg00166722 chr3:10149974 C3orf24 -0.66 -8.96 -0.44 2.55e-17 Alzheimer's disease; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg11361691 chr3:57993876 FLNB 0.37 6.2 0.32 1.73e-9 Liver disease severity in Alagille syndrome; CRC cis rs6564851 0.506 rs11648145 chr16:81257977 T/C cg05274606 chr16:81253692 PKD1L2 -0.36 -5.81 -0.31 1.45e-8 Carotenoid and tocopherol levels; CRC cis rs1799949 1.000 rs33926631 chr17:41304463 T/C cg23758822 chr17:41437982 NA 0.79 13.45 0.6 3.54e-33 Menopause (age at onset); CRC cis rs2073499 1.000 rs45536634 chr3:50400081 G/A cg09545109 chr3:50388910 TUSC4;CYB561D2 0.69 5.93 0.31 7.85e-9 Schizophrenia; CRC cis rs780096 0.546 rs2293572 chr2:27728777 C/G cg12648201 chr2:27665141 KRTCAP3 0.3 5.95 0.31 6.96e-9 Total body bone mineral density; CRC cis rs10751667 0.666 rs7103585 chr11:971166 T/C cg23136738 chr11:925521 AP2A2 -0.42 -7.09 -0.36 8.19e-12 Alzheimer's disease (late onset); CRC cis rs6842047 0.706 rs4862667 chr4:187136416 A/G cg09526685 chr4:187126073 CYP4V2 0.49 6.47 0.34 3.51e-10 Blood protein levels; CRC trans rs561341 1.000 rs546748 chr17:30324293 A/C cg20587970 chr11:113659929 NA -0.98 -14.41 -0.62 7.74e-37 Hip circumference adjusted for BMI; CRC cis rs11098499 0.863 rs3822195 chr4:120471660 C/T cg24375607 chr4:120327624 NA 0.48 7.32 0.37 1.91e-12 Corneal astigmatism; CRC cis rs9287719 0.967 rs4668691 chr2:10740494 C/T cg00105475 chr2:10696890 NA 0.45 7.3 0.37 2.19e-12 Prostate cancer; CRC cis rs769267 0.930 rs3794990 chr19:19610030 A/G cg03709012 chr19:19516395 GATAD2A 0.73 11.32 0.53 2.66e-25 Tonsillectomy; CRC cis rs7640424 1.000 rs7640424 chr3:107820063 C/T cg09227934 chr3:107805635 CD47 -0.52 -7.54 -0.38 4.65e-13 Body mass index; CRC cis rs365302 1.000 rs418902 chr6:159648864 T/A cg14500486 chr6:159655392 FNDC1 0.44 6.87 0.35 3.15e-11 Coronary heart disease; CRC cis rs17345786 0.954 rs17508319 chr3:101318903 G/A cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.58 6.78 0.35 5.68e-11 Colonoscopy-negative controls vs population controls; CRC trans rs12699921 0.632 rs2723501 chr7:17854532 A/C cg02066331 chr6:17282778 RBM24 0.36 6.36 0.33 6.86e-10 Fibrinogen levels; CRC cis rs34172651 0.917 rs6497756 chr16:24798291 G/T cg06028605 chr16:24865363 SLC5A11 0.39 7.26 0.37 2.9e-12 Intelligence (multi-trait analysis); CRC cis rs28386778 0.897 rs8069969 chr17:61822223 T/G cg06601766 chr17:61851465 DDX42;CCDC47 0.44 5.98 0.31 5.83e-9 Prudent dietary pattern; CRC cis rs7705042 0.865 rs4912805 chr5:141493685 A/G cg08523384 chr5:141488047 NDFIP1 -0.34 -5.9 -0.31 9e-9 Asthma; CRC cis rs1552244 0.935 rs6805869 chr3:10119917 T/C cg02579736 chr3:10068473 FANCD2;CIDECP 0.97 13.2 0.59 3.17e-32 Alzheimer's disease; CRC trans rs7821565 0.904 rs1370443 chr8:52164230 A/G cg09187163 chr7:72721838 NSUN5 -0.41 -5.98 -0.31 5.79e-9 Tuberculosis; CRC cis rs860295 0.639 rs10908469 chr1:155468732 A/C cg02153340 chr1:155202674 NA -0.53 -6.69 -0.35 9.55e-11 Body mass index; CRC cis rs9467773 0.935 rs11752946 chr6:26560364 C/A cg15676542 chr6:26421231 BTN2A3 0.32 5.61 0.3 4.3e-8 Intelligence (multi-trait analysis); CRC cis rs9914988 0.945 rs9279 chr17:27187636 G/T cg20469991 chr17:27169893 C17orf63 0.47 5.87 0.31 1.05e-8 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs72627123 0.737 rs77361581 chr14:74465290 A/G cg12022184 chr14:74485813 ENTPD5;C14orf45 0.72 6.0 0.31 5.3300000000000004e-09 Morning vs. evening chronotype; CRC cis rs651907 0.557 rs17411983 chr3:101399126 A/G cg12386194 chr3:101231763 SENP7 -0.48 -6.97 -0.36 1.72e-11 Colorectal cancer; CRC cis rs597539 0.615 rs583182 chr11:68678634 C/T cg21963583 chr11:68658836 MRPL21 0.61 11.47 0.53 7.48e-26 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs8177253 0.606 rs6787177 chr3:133450720 C/T cg11941060 chr3:133502564 NA -0.48 -7.87 -0.4 5.07e-14 Iron status biomarkers; CRC cis rs2227564 0.649 rs2688626 chr10:75611090 G/A cg16540259 chr10:75572220 NDST2 0.44 6.38 0.33 6.07e-10 Crohn's disease;Inflammatory bowel disease; CRC cis rs823143 0.570 rs823084 chr1:205798313 G/T cg23034840 chr1:205782522 SLC41A1 0.69 11.25 0.53 4.6e-25 Monocyte percentage of white cells; CRC cis rs6694672 0.867 rs4915378 chr1:197161212 T/G cg13682187 chr1:196946512 CFHR5 0.44 7.13 0.37 6.61e-12 Asthma; CRC cis rs743757 0.938 rs2282753 chr3:50436716 C/T cg09545109 chr3:50388910 TUSC4;CYB561D2 0.44 6.42 0.33 4.73e-10 Diastolic blood pressure; CRC cis rs6662572 0.737 rs7532388 chr1:46472734 G/A cg03123370 chr1:45965343 CCDC163P;MMACHC 0.46 5.87 0.31 1.09e-8 Blood protein levels; CRC cis rs11098499 0.754 rs10213554 chr4:120260785 A/G cg09307838 chr4:120376055 NA -0.63 -9.55 -0.47 3.13e-19 Corneal astigmatism; CRC cis rs9611519 0.602 rs8138520 chr22:41412928 A/G cg03806693 chr22:41940476 POLR3H -0.41 -5.75 -0.3 2.02e-8 Neuroticism; CRC cis rs9303401 0.659 rs1864754 chr17:56688789 G/T cg02118635 chr17:56770003 RAD51C;TEX14 -0.78 -9.98 -0.48 1.14e-20 Cognitive test performance; CRC cis rs11662586 0.517 rs7230837 chr18:77695384 A/T cg20368463 chr18:77673604 PQLC1 0.66 10.86 0.51 1.12e-23 Exploratory eye movement dysfunction in schizophrenia (responsive search score); CRC cis rs2354432 0.607 rs59689207 chr1:146722484 G/A cg25205988 chr1:146714368 CHD1L -1.17 -9.75 -0.47 6.94e-20 Mitochondrial DNA levels; CRC cis rs10504229 0.683 rs56211106 chr8:58113497 A/G cg22535103 chr8:58192502 C8orf71 -0.69 -9.23 -0.45 3.37e-18 Developmental language disorder (linguistic errors); CRC cis rs2439831 0.850 rs11856795 chr15:44160582 G/T cg02155558 chr15:43621948 ADAL;LCMT2 0.69 7.17 0.37 4.89e-12 Lung cancer in ever smokers; CRC cis rs9807989 0.801 rs11123925 chr2:102977511 G/A cg03938978 chr2:103052716 IL18RAP 0.37 6.1 0.32 3.01e-9 Asthma; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg16063989 chr7:139929855 NA 0.42 6.54 0.34 2.35e-10 Liver disease severity in Alagille syndrome; CRC cis rs9914988 0.943 rs2046759 chr17:27138817 T/C cg07195577 chr17:27052828 TLCD1 0.42 5.99 0.31 5.62e-9 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs68170813 0.559 rs7798223 chr7:106829223 T/C cg02696742 chr7:106810147 HBP1 -0.62 -6.8 -0.35 4.83e-11 Coronary artery disease; CRC cis rs10883723 0.810 rs7092622 chr10:104249919 T/G cg22532475 chr10:104410764 TRIM8 -0.37 -6.8 -0.35 4.94e-11 Allergic disease (asthma, hay fever or eczema); CRC cis rs9611565 0.918 rs4822024 chr22:41757647 G/A cg06634786 chr22:41940651 POLR3H -0.56 -7.03 -0.36 1.2e-11 Vitiligo; CRC cis rs6952808 0.630 rs1860832 chr7:2161849 G/A cg22963979 chr7:1858916 MAD1L1 -0.43 -6.2 -0.32 1.72e-9 Bipolar disorder and schizophrenia; CRC cis rs7937682 0.889 rs11213969 chr11:111528441 A/G cg19812747 chr11:111475976 SIK2 -0.57 -9.67 -0.47 1.21e-19 Primary sclerosing cholangitis; CRC cis rs2276314 1.000 rs4799835 chr18:33571268 G/A cg05985134 chr18:33552581 C18orf21 0.51 6.67 0.35 1.1e-10 Endometriosis;Drug-induced torsades de pointes; CRC cis rs5758343 1 rs5758343 chr22:41816652 A/T cg06481639 chr22:41940642 POLR3H 0.52 5.7 0.3 2.61e-8 Allergic disease (asthma, hay fever or eczema); CRC cis rs6918586 0.658 rs198828 chr6:26119459 G/A cg18357526 chr6:26021779 HIST1H4A -0.49 -7.29 -0.37 2.27e-12 Schizophrenia; CRC cis rs524281 0.861 rs12049852 chr11:65884702 T/C cg16950941 chr11:66035639 RAB1B -0.57 -7.35 -0.38 1.61e-12 Electroencephalogram traits; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg08806348 chr19:14201154 SAMD1 0.44 6.15 0.32 2.25e-9 Response to antipsychotic treatment; CRC cis rs2204008 0.604 rs2320521 chr12:38253789 A/G cg26384229 chr12:38710491 ALG10B 0.67 9.01 0.44 1.77e-17 Bladder cancer; CRC trans rs4398173 1.000 rs4398173 chr18:6941108 A/G cg11797573 chr7:158219200 PTPRN2 0.35 6.0 0.31 5.22e-9 Response to citalopram treatment; CRC cis rs6456156 0.773 rs6456159 chr6:167529272 T/A cg19688584 chr6:167529678 CCR6 -0.34 -6.16 -0.32 2.09e-9 Primary biliary cholangitis; CRC cis rs7618501 0.633 rs6446189 chr3:50008566 A/G cg05623727 chr3:50126028 RBM5 0.45 7.52 0.38 5.18e-13 Intelligence (multi-trait analysis); CRC trans rs1005277 0.505 rs200937 chr10:38135772 T/C cg17830980 chr10:43048298 ZNF37B -0.41 -6.38 -0.33 6.11e-10 Extrinsic epigenetic age acceleration; CRC cis rs9914988 0.943 rs11658884 chr17:27132742 A/G cg16670446 chr17:27188758 MIR451;MIR144 -0.54 -8.45 -0.42 9.38e-16 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC trans rs1455244 0.700 rs7229302 chr18:11508904 G/T cg01656856 chr2:170551263 PHOSPHO2;KLHL23;C2orf77 0.48 7.39 0.38 1.21e-12 Schizophrenia; CRC cis rs7584330 0.554 rs77380873 chr2:238426551 C/T cg08992911 chr2:238395768 MLPH 0.64 6.48 0.34 3.43e-10 Prostate cancer; CRC cis rs12451471 0.500 rs8077056 chr17:78076006 C/T cg20811857 chr17:78079795 GAA -0.46 -6.72 -0.35 8.06e-11 Plateletcrit;Mean corpuscular hemoglobin concentration; CRC cis rs13108904 0.905 rs1680074 chr4:1279621 G/A cg15763984 chr4:1342303 KIAA1530 -0.35 -6.08 -0.32 3.29e-9 Obesity-related traits; CRC cis rs9468199 1.000 rs9468199 chr6:27681215 G/A cg20933634 chr6:27740509 NA 0.46 5.92 0.31 8.13e-9 Parkinson's disease; CRC cis rs34375054 0.738 rs10846834 chr12:125625570 A/G cg02766259 chr12:125626809 AACS -0.43 -8.18 -0.41 6.23e-15 Post bronchodilator FEV1/FVC ratio; CRC cis rs2239547 0.563 rs4687699 chr3:53101224 C/T cg11645453 chr3:52864694 ITIH4 0.52 9.09 0.45 9.28e-18 Schizophrenia; CRC cis rs7666738 0.830 rs991168 chr4:98928293 T/C cg05340658 chr4:99064831 C4orf37 0.6 9.35 0.46 1.41e-18 Colonoscopy-negative controls vs population controls; CRC cis rs1639906 0.708 rs3779013 chr7:2210844 A/G cg19897017 chr7:2163380 MAD1L1 0.65 9.21 0.45 4.03e-18 Colonoscopy-negative controls vs population controls; CRC cis rs7618915 0.508 rs11717043 chr3:52656092 A/T cg07507251 chr3:52567010 NT5DC2 0.43 6.15 0.32 2.19e-9 Bipolar disorder; CRC cis rs45509595 0.841 rs370155 chr6:27782031 T/G cg26587870 chr6:27730563 NA -0.66 -6.83 -0.35 4.21e-11 Breast cancer; CRC cis rs9291683 0.588 rs4280729 chr4:10013861 C/T cg11266682 chr4:10021025 SLC2A9 0.53 11.38 0.53 1.55e-25 Bone mineral density; CRC trans rs1117324 1.000 rs1117324 chr2:21840093 C/T cg15889231 chr14:107239010 NA -0.56 -6.37 -0.33 6.43e-10 Response to antipsychotic treatment; CRC cis rs11105298 0.891 rs10858903 chr12:89927972 G/A cg08166232 chr12:89918718 WDR51B;GALNT4 -0.61 -7.63 -0.39 2.57e-13 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; CRC cis rs6693567 0.545 rs11205382 chr1:150442466 G/A cg04165759 chr1:150448943 RPRD2 -0.35 -5.73 -0.3 2.27e-8 Migraine; CRC cis rs780096 0.526 rs11127013 chr2:27692973 A/G cg27432699 chr2:27873401 GPN1 -0.62 -9.48 -0.46 5.39e-19 Total body bone mineral density; CRC cis rs540254 0.647 rs12405457 chr1:160759052 A/G cg20255094 chr1:160771763 LY9 0.49 6.14 0.32 2.34e-9 Blood protein levels; CRC cis rs4363385 0.818 rs532773 chr1:153011750 T/A cg25856811 chr1:152973957 SPRR3 -0.25 -7.0 -0.36 1.49e-11 Inflammatory skin disease; CRC cis rs10751667 0.666 rs10902243 chr11:949900 T/C ch.11.42038R chr11:967971 AP2A2 0.57 9.77 0.47 5.76e-20 Alzheimer's disease (late onset); CRC cis rs67311347 1.000 rs9849992 chr3:40402140 C/T cg09455208 chr3:40491958 NA 0.44 8.82 0.44 6.83e-17 Renal cell carcinoma; CRC cis rs1153858 1.000 rs11858495 chr15:45637662 A/G cg10760299 chr15:45669010 GATM -0.41 -6.28 -0.33 1.09e-9 Homoarginine levels; CRC cis rs9368481 0.729 rs9379950 chr6:26961548 T/C cg18278486 chr6:26987575 LOC100270746;C6orf41 -0.48 -7.39 -0.38 1.21e-12 Autism spectrum disorder or schizophrenia; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg08409687 chr2:201936025 NDUFB3;FAM126B 0.53 6.98 0.36 1.64e-11 Thyroid stimulating hormone; CRC trans rs11098499 0.909 rs11098530 chr4:120413154 C/T cg25214090 chr10:38739885 LOC399744 0.66 10.54 0.5 1.46e-22 Corneal astigmatism; CRC cis rs208520 1.000 rs9453671 chr6:66991208 A/G cg07460842 chr6:66804631 NA 0.91 11.09 0.52 1.75e-24 Exhaled nitric oxide output; CRC cis rs6831352 0.918 rs13129488 chr4:100053025 G/T cg12011299 chr4:100065546 ADH4 -0.49 -9.27 -0.45 2.61e-18 Alcohol dependence; CRC cis rs6840360 0.593 rs3805356 chr4:152680701 C/T cg09659197 chr4:152720779 NA -0.42 -8.73 -0.43 1.26e-16 Intelligence (multi-trait analysis); CRC cis rs4148883 0.629 rs10009145 chr4:100047929 G/A cg13256891 chr4:100009986 ADH5 0.46 6.61 0.34 1.51e-10 Alcohol dependence; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg25867694 chr22:31503597 SELM 0.41 6.82 0.35 4.42e-11 Liver disease severity in Alagille syndrome; CRC trans rs12478296 0.792 rs6738361 chr2:243014257 C/T cg06834434 chr14:75079333 LTBP2 0.51 6.03 0.32 4.48e-9 Obesity-related traits; CRC cis rs7772486 0.754 rs864148 chr6:145976675 T/C cg23711669 chr6:146136114 FBXO30 -0.74 -12.38 -0.56 3.73e-29 Lobe attachment (rater-scored or self-reported); CRC trans rs11148252 0.553 rs7999849 chr13:53249414 A/G cg18335740 chr13:41363409 SLC25A15 0.75 13.47 0.6 3e-33 Lewy body disease; CRC cis rs12594515 1.000 rs8025258 chr15:45987554 C/A cg06207120 chr15:45996521 NA 0.32 7.75 0.39 1.14e-13 Waist circumference;Weight; CRC cis rs3091242 0.902 rs36003018 chr1:25784318 A/G cg20684491 chr1:25596433 NA -0.43 -7.39 -0.38 1.23e-12 Erythrocyte sedimentation rate; CRC cis rs2012796 0.956 rs7147254 chr14:81820503 G/A cg02996355 chr14:81879375 NA 0.55 8.17 0.41 6.9e-15 Night sleep phenotypes; CRC cis rs870825 0.655 rs2017101 chr4:185637381 G/A cg04058563 chr4:185651563 MLF1IP 0.73 9.38 0.46 1.13e-18 Blood protein levels; CRC cis rs3790844 0.876 rs61486545 chr1:200008337 G/A cg07208853 chr1:200005219 NR5A2 0.34 8.28 0.42 3.14e-15 Pancreatic cancer; CRC cis rs8067545 0.532 rs35915823 chr17:19973397 A/G cg13482628 chr17:19912719 NA 0.42 6.0 0.31 5.07e-9 Schizophrenia; CRC cis rs11148252 0.595 rs4885325 chr13:53171317 C/T cg20354231 chr13:53171401 NA -0.44 -7.17 -0.37 4.88e-12 Lewy body disease; CRC cis rs2898681 0.837 rs2017237 chr4:53748515 A/G cg00338735 chr4:53728038 RASL11B 0.36 5.68 0.3 3.01e-8 Optic nerve measurement (cup area); CRC cis rs1129187 0.755 rs9471986 chr6:42944127 A/G cg00597713 chr6:42947103 PEX6 -0.41 -5.71 -0.3 2.51e-8 Alzheimer's disease in APOE e4+ carriers; CRC cis rs11190604 0.943 rs2495744 chr10:102329409 C/T cg07080220 chr10:102295463 HIF1AN 0.45 5.66 0.3 3.38e-8 Palmitoleic acid (16:1n-7) levels; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg06589507 chr5:179234594 SQSTM1;MGAT4B 0.5 6.64 0.34 1.3100000000000001e-10 Thyroid stimulating hormone; CRC cis rs6951245 0.935 rs112554101 chr7:1065535 A/G cg20603222 chr7:1096387 C7orf50;GPR146 -0.56 -7.33 -0.37 1.76e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs6502050 0.835 rs9911379 chr17:80114529 A/G cg02741985 chr17:80059408 CCDC57 0.44 7.34 0.38 1.68e-12 Life satisfaction; CRC cis rs9733 0.519 rs3768005 chr1:150680988 A/T cg10589385 chr1:150898437 SETDB1 0.31 6.48 0.34 3.32e-10 Tonsillectomy; CRC trans rs453301 0.719 rs34004903 chr8:8892604 C/T cg16141378 chr3:129829833 LOC729375 0.4 6.11 0.32 2.85e-9 Joint mobility (Beighton score); CRC cis rs6557786 0.636 rs2445940 chr8:24787201 C/G cg19677607 chr8:24772270 NEFM 0.37 5.88 0.31 1.03e-8 Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 2 peripheral neuropathy); CRC cis rs4243830 0.850 rs1064835 chr1:6585539 A/G cg22792644 chr1:6614718 TAS1R1;NOL9 0.68 8.43 0.42 1.13e-15 Body mass index; CRC cis rs6951245 1.000 rs1997243 chr7:1083777 A/G cg21664854 chr7:1097933 C7orf50;GPR146 0.79 8.94 0.44 2.89e-17 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs7584330 0.504 rs7598417 chr2:238435265 C/G cg16989719 chr2:238392110 NA -0.34 -5.87 -0.31 1.06e-8 Prostate cancer; CRC cis rs4969178 0.965 rs12451791 chr17:76397343 G/A cg05887092 chr17:76393375 PGS1 0.55 10.0 0.48 1.01e-20 HDL cholesterol levels; CRC cis rs79387448 1.000 rs79387448 chr2:103215410 C/T cg21010569 chr2:103233596 NA 0.6 6.67 0.34 1.11e-10 Gut microbiota (bacterial taxa); CRC trans rs73162807 0.655 rs73160990 chr3:146434154 A/T cg26896787 chr1:228603707 TRIM17 -0.59 -5.99 -0.31 5.61e-9 Platelet-derived growth factor BB levels; CRC cis rs992157 0.835 rs12987219 chr2:219144149 G/A cg04880052 chr2:219191631 PNKD -0.44 -6.99 -0.36 1.5e-11 Colorectal cancer; CRC cis rs1878931 0.597 rs37816 chr16:3456371 G/A cg02880119 chr16:3481970 NA 0.47 6.59 0.34 1.73e-10 Body mass index (adult); CRC trans rs9581094 1.000 rs73154401 chr13:25085667 C/A ch.10.2420334F chr10:115122200 NA 0.61 6.01 0.31 4.94e-9 Sudden cardiac arrest; CRC cis rs13333054 1.000 rs13333054 chr16:86011033 C/T cg04454285 chr16:86016317 NA 0.81 11.58 0.54 3.17e-26 Multiple sclerosis; CRC cis rs9926296 0.529 rs7195906 chr16:89806347 A/T cg27121462 chr16:89883253 FANCA 0.56 8.89 0.44 3.99e-17 Vitiligo; CRC cis rs6540556 0.723 rs11119331 chr1:209889712 G/A cg05527609 chr1:210001259 C1orf107 -0.56 -5.88 -0.31 1.01e-8 Red blood cell count; CRC cis rs10876993 0.855 rs10877007 chr12:58100058 T/A cg18357645 chr12:58087776 OS9 0.61 8.65 0.43 2.31e-16 Celiac disease or Rheumatoid arthritis; CRC cis rs8077889 0.917 rs58080788 chr17:41902909 A/G cg16892393 chr17:41919603 NA 0.5 7.58 0.39 3.55e-13 Triglycerides; CRC cis rs9902453 0.817 rs9909128 chr17:28161482 C/T cg26525008 chr17:28256777 EFCAB5;SSH2 0.71 11.93 0.55 1.69e-27 Coffee consumption (cups per day); CRC cis rs6933660 0.800 rs963193 chr6:151789355 G/T cg10883421 chr6:151773342 RMND1;C6orf211 -0.75 -13.52 -0.6 1.94e-33 Menarche (age at onset); CRC cis rs12476592 0.602 rs262521 chr2:63892485 C/T cg10828910 chr2:63850056 LOC388955 0.49 6.33 0.33 7.85e-10 Childhood ear infection; CRC cis rs951366 0.789 rs823110 chr1:205701078 G/C cg14893161 chr1:205819251 PM20D1 0.83 13.16 0.59 4.52e-32 Menarche (age at onset); CRC cis rs3996993 0.573 rs11759734 chr6:52724146 A/G cg20803780 chr6:52668592 GSTA1 0.39 6.6 0.34 1.62e-10 Hemoglobin concentration; CRC trans rs57221529 0.766 rs72703026 chr5:572383 G/A cg11887960 chr12:57824829 NA 0.59 6.4 0.33 5.2400000000000005e-10 Lung disease severity in cystic fibrosis; CRC cis rs10256972 0.516 rs12702081 chr7:1141528 T/C cg23708337 chr7:1209742 NA 0.4 6.0 0.31 5.23e-9 Longevity;Endometriosis; CRC cis rs12024301 0.557 rs10797896 chr1:183589800 A/G cg11505048 chr1:183622726 RGL1;APOBEC4 0.76 6.92 0.36 2.41e-11 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs769267 0.896 rs7253807 chr19:19631444 A/T cg02546618 chr19:19431379 KIAA0892;SF4 0.46 6.38 0.33 6.15e-10 Tonsillectomy; CRC cis rs864537 0.590 rs1214596 chr1:167427170 A/T cg22356347 chr1:167427500 CD247 0.39 5.8 0.3 1.53e-8 Celiac disease or Rheumatoid arthritis;Celiac disease; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg00615892 chr16:69166530 CHTF8;CIRH1A 0.42 6.48 0.34 3.41e-10 Liver disease severity in Alagille syndrome; CRC cis rs34172651 0.917 rs8049667 chr16:24773524 G/A cg00339695 chr16:24857497 SLC5A11 0.3 6.93 0.36 2.18e-11 Intelligence (multi-trait analysis); CRC cis rs7274811 0.711 rs291697 chr20:31985248 T/C cg03904042 chr20:32255491 NECAB3;C20orf134 0.41 5.77 0.3 1.87e-8 Height; CRC cis rs1799949 1.000 rs36036395 chr17:41181297 T/C cg23758822 chr17:41437982 NA 0.8 13.22 0.59 2.77e-32 Menopause (age at onset); CRC cis rs1697139 0.935 rs1627990 chr5:66513326 C/T cg16691251 chr5:66510806 NA 0.56 11.17 0.52 8.69e-25 Breast cancer; CRC cis rs28386778 0.897 rs2665796 chr17:61923716 G/C cg07362569 chr17:61921086 SMARCD2 0.37 5.71 0.3 2.47e-8 Prudent dietary pattern; CRC trans rs1455244 0.700 rs7229302 chr18:11508904 G/T cg17216071 chr19:18392551 JUND 0.4 6.31 0.33 8.99e-10 Schizophrenia; CRC cis rs2677744 0.626 rs11857545 chr15:91489705 G/A cg23684204 chr15:91497937 RCCD1 0.42 6.34 0.33 7.4e-10 Attention deficit hyperactivity disorder; CRC cis rs1799949 1.000 rs3092988 chr17:41201702 C/T cg05368731 chr17:41323189 NBR1 0.65 9.68 0.47 1.13e-19 Menopause (age at onset); CRC cis rs34172651 0.517 rs12920774 chr16:24830750 T/C cg06028605 chr16:24865363 SLC5A11 0.55 8.6 0.43 3.37e-16 Intelligence (multi-trait analysis); CRC cis rs3858526 0.883 rs10769326 chr11:5934358 C/T cg05234568 chr11:5960015 NA -0.54 -7.48 -0.38 6.77e-13 DNA methylation (variation); CRC trans rs4718428 1.000 rs4718428 chr7:66421446 T/G cg18876405 chr7:65276391 NA 0.4 6.15 0.32 2.25e-9 Corneal structure; CRC cis rs3820068 0.581 rs16851848 chr1:15927698 G/A cg24675056 chr1:15929824 NA 0.49 6.72 0.35 8.13e-11 Systolic blood pressure; CRC cis rs2380220 0.576 rs4498363 chr6:96042338 A/C cg15832292 chr6:96025679 MANEA 0.58 6.33 0.33 7.84e-10 Behavioural disinhibition (generation interaction); CRC cis rs875971 0.660 rs1860470 chr7:66103694 G/C cg00343986 chr7:65444356 GUSB -0.51 -7.62 -0.39 2.66e-13 Aortic root size; CRC cis rs2227564 0.700 rs2675677 chr10:75648249 C/A cg00564723 chr10:75632066 CAMK2G -0.3 -6.89 -0.36 2.87e-11 Crohn's disease;Inflammatory bowel disease; CRC cis rs7833986 1.000 rs13281873 chr8:57101799 C/A cg23139584 chr8:56987506 RPS20;SNORD54 0.62 7.78 0.39 9.23e-14 Height; CRC cis rs8177253 0.965 rs4854761 chr3:133498789 A/G cg08048268 chr3:133502702 NA 0.37 7.07 0.36 9.28e-12 Iron status biomarkers; CRC cis rs7618915 0.547 rs2268027 chr3:52766606 G/A cg11645453 chr3:52864694 ITIH4 0.36 6.31 0.33 8.84e-10 Bipolar disorder; CRC cis rs992157 0.735 rs13393821 chr2:219076742 C/G cg04731861 chr2:219085781 ARPC2 -0.32 -6.81 -0.35 4.61e-11 Colorectal cancer; CRC cis rs4713118 0.662 rs9380045 chr6:28025279 A/G cg15845792 chr6:28175446 NA 0.96 13.94 0.61 5.17e-35 Parkinson's disease; CRC cis rs919433 0.889 rs12472355 chr2:198205840 C/A cg03934865 chr2:198174659 NA -0.4 -6.39 -0.33 5.71e-10 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC trans rs56114371 0.777 rs200481 chr6:27773832 A/T cg16898833 chr6:26189333 HIST1H4D 0.66 6.19 0.32 1.83e-9 Breast cancer; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg07549269 chr21:33765057 C21orf119;URB1 0.4 6.21 0.32 1.59e-9 Liver disease severity in Alagille syndrome; CRC cis rs35110281 0.667 rs4819286 chr21:45120121 G/A cg04455712 chr21:45112962 RRP1B 0.4 7.81 0.4 7.68e-14 Mean corpuscular volume; CRC cis rs12824058 0.831 rs11616174 chr12:130814503 A/G cg24838063 chr12:130822603 PIWIL1 0.57 9.65 0.47 1.47e-19 Menopause (age at onset); CRC cis rs7731657 0.537 rs4705850 chr5:130220358 A/G cg08523029 chr5:130500466 HINT1 -0.49 -6.39 -0.33 5.71e-10 Fasting plasma glucose; CRC cis rs9549367 0.789 rs2287244 chr13:113887173 C/G cg18105134 chr13:113819100 PROZ 0.74 11.71 0.54 1.03e-26 Platelet distribution width; CRC cis rs561341 1.000 rs546519 chr17:30297682 T/G cg19193384 chr17:30244184 NA -0.53 -6.66 -0.34 1.15e-10 Hip circumference adjusted for BMI; CRC cis rs9894429 1.000 rs9748176 chr17:79584043 C/G cg13777783 chr17:79615861 NA -0.3 -5.71 -0.3 2.54e-8 Eye color traits; CRC cis rs4936891 0.557 rs55954258 chr11:123914759 A/G cg22125253 chr11:123886957 OR10G4 -0.34 -6.13 -0.32 2.49e-9 Male fertility; CRC cis rs8141529 0.748 rs1318025 chr22:29283757 C/T cg15103426 chr22:29168792 CCDC117 0.48 6.59 0.34 1.79e-10 Lymphocyte counts; CRC cis rs6499255 0.904 rs12595927 chr16:69716338 C/G cg04110750 chr16:69646130 NFAT5 -0.6 -7.9 -0.4 4.16e-14 IgE levels; CRC cis rs806215 0.950 rs3757793 chr7:127225780 G/A cg25922125 chr7:127225783 GCC1 -0.74 -7.76 -0.39 1.06e-13 Type 2 diabetes; CRC cis rs6694672 1.000 rs928440 chr1:196950350 G/A cg13682187 chr1:196946512 CFHR5 -0.48 -7.61 -0.39 2.83e-13 Asthma; CRC cis rs910316 0.935 rs3742771 chr14:75599647 A/G cg11812906 chr14:75593930 NEK9 0.61 9.62 0.47 1.84e-19 Height; CRC trans rs7615952 0.558 rs7641353 chr3:125339879 T/C cg00769240 chr8:12517080 NA -0.72 -9.89 -0.48 2.24e-20 Blood pressure (smoking interaction); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg09951048 chr8:21966736 NUDT18 0.38 6.02 0.31 4.6e-9 Intelligence (multi-trait analysis); CRC cis rs10911232 0.507 rs11582514 chr1:182992161 T/C ch.1.3577855R chr1:183094577 LAMC1 0.86 15.17 0.64 8.93e-40 Hypertriglyceridemia; CRC cis rs11148252 0.740 rs9526914 chr13:52976300 G/T cg12458913 chr13:53173898 NA 0.48 7.23 0.37 3.5e-12 Lewy body disease; CRC cis rs2070488 0.804 rs2276541 chr3:38512779 G/A cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.79 13.72 0.6 3.52e-34 Electrocardiographic conduction measures; CRC cis rs10504229 0.593 rs116916898 chr8:57984958 G/A cg11062466 chr8:58055876 NA 0.52 5.61 0.3 4.25e-8 Developmental language disorder (linguistic errors); CRC cis rs9322193 0.736 rs3805750 chr6:150112201 G/A cg05861140 chr6:150128134 PCMT1 -0.44 -7.18 -0.37 4.63e-12 Lung cancer; CRC cis rs6088590 1.000 rs6120748 chr20:33458284 T/G cg24642439 chr20:33292090 TP53INP2 0.52 8.81 0.44 7.46e-17 Coronary artery disease; CRC cis rs9303401 0.625 rs66508449 chr17:56691034 T/C cg02118635 chr17:56770003 RAD51C;TEX14 0.73 9.11 0.45 8.37e-18 Cognitive test performance; CRC cis rs17780086 0.527 rs72827711 chr17:30537920 T/A cg00745463 chr17:30367425 LRRC37B -0.86 -8.13 -0.41 9.08e-15 Height; CRC cis rs4743820 0.503 rs10820835 chr9:93921227 C/T cg14446406 chr9:93919335 NA 0.49 8.76 0.44 1.02e-16 Ulcerative colitis;Inflammatory bowel disease; CRC cis rs62229266 0.804 rs12483151 chr21:37419578 C/T cg12218747 chr21:37451666 NA -0.43 -7.41 -0.38 1.09e-12 Mitral valve prolapse; CRC cis rs7726839 0.540 rs56325086 chr5:640728 G/A cg17948913 chr5:572064 NA 0.5 5.73 0.3 2.26e-8 Obesity-related traits; CRC trans rs7615952 0.546 rs2979338 chr3:125343126 G/T cg00769240 chr8:12517080 NA -0.65 -7.34 -0.38 1.67e-12 Blood pressure (smoking interaction); CRC cis rs9534288 0.830 rs1409435 chr13:46631660 G/A cg15192986 chr13:46630673 CPB2 -0.78 -10.96 -0.52 5.02e-24 Blood protein levels; CRC cis rs9486719 1.000 rs4839837 chr6:96908706 G/A cg06623918 chr6:96969491 KIAA0776 0.8 10.93 0.52 6.36e-24 Migraine;Coronary artery disease; CRC cis rs593982 0.920 rs488170 chr11:65481544 T/C cg08755490 chr11:65554678 OVOL1 0.93 9.99 0.48 1.08e-20 Atopic dermatitis; CRC cis rs10504229 0.683 rs17194995 chr8:58109220 A/C cg02290350 chr8:58132656 NA 0.55 6.57 0.34 1.94e-10 Developmental language disorder (linguistic errors); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg15703646 chr7:100209939 MOSPD3 0.41 6.01 0.31 4.82e-9 Intelligence (multi-trait analysis); CRC cis rs7727544 0.647 rs72793280 chr5:131562900 C/T cg18301423 chr5:131593218 PDLIM4 0.31 5.6 0.3 4.51e-8 Blood metabolite levels; CRC cis rs12681288 0.645 rs2600509 chr8:989022 C/G cg15309053 chr8:964076 NA -0.41 -7.02 -0.36 1.28e-11 Schizophrenia; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg23181138 chr9:88356705 AGTPBP1 0.43 5.99 0.31 5.48e-9 Response to antipsychotic treatment; CRC cis rs2336384 1.000 rs1810563 chr1:12054030 A/G cg13216073 chr1:12042593 MFN2 -0.52 -7.16 -0.37 5.22e-12 Platelet count; CRC cis rs1832871 0.643 rs7750656 chr6:158725907 C/T cg07165851 chr6:158734300 TULP4 0.62 7.76 0.39 1.07e-13 Height; CRC trans rs17111396 0.627 rs59741121 chr14:81502778 T/C cg22745369 chr6:3517953 NA -0.43 -6.15 -0.32 2.19e-9 Uric acid levels; CRC cis rs9291683 0.588 rs13113730 chr4:10017628 C/T cg00071950 chr4:10020882 SLC2A9 0.68 13.33 0.59 1.07e-32 Bone mineral density; CRC cis rs7715806 0.500 rs17649350 chr5:75006156 C/T cg00601450 chr5:74908170 NA -0.46 -6.01 -0.31 4.98e-9 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs2996428 0.667 rs17412654 chr1:3758493 T/C cg13057898 chr1:3703894 LRRC47 0.53 6.99 0.36 1.53e-11 Red cell distribution width; CRC cis rs875971 0.862 rs6947339 chr7:65888470 T/C cg12463550 chr7:65579703 CRCP 0.48 6.5 0.34 2.91e-10 Aortic root size; CRC cis rs4481887 0.830 rs4474289 chr1:248474972 T/A cg13385794 chr1:248469461 NA 0.37 6.58 0.34 1.88e-10 Common traits (Other); CRC cis rs910316 0.737 rs175055 chr14:75488946 T/G cg08847533 chr14:75593920 NEK9 -0.83 -14.26 -0.62 3.02e-36 Height; CRC cis rs875971 0.862 rs12698521 chr7:65939489 T/C cg18912574 chr7:65842487 NCRNA00174 0.36 6.1 0.32 2.97e-9 Aortic root size; CRC trans rs10411161 0.580 rs12151288 chr19:52381552 A/G cg22319618 chr22:45562946 NUP50 -0.48 -6.49 -0.34 3.23e-10 Breast cancer; CRC cis rs11098499 0.754 rs2036856 chr4:120249288 G/A cg24375607 chr4:120327624 NA 0.47 7.59 0.39 3.42e-13 Corneal astigmatism; CRC cis rs9486719 0.741 rs2499799 chr6:96851676 T/C cg06623918 chr6:96969491 KIAA0776 0.76 8.12 0.41 9.6e-15 Migraine;Coronary artery disease; CRC cis rs10751667 0.666 rs7396509 chr11:956761 G/A ch.11.42038R chr11:967971 AP2A2 0.58 10.06 0.49 6e-21 Alzheimer's disease (late onset); CRC cis rs7264396 0.790 rs3787164 chr20:34228866 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.59 -9.76 -0.47 6.07e-20 Total cholesterol levels; CRC cis rs11958404 1.000 rs11958404 chr5:157410278 A/T cg05962755 chr5:157440814 NA 0.83 10.82 0.51 1.57e-23 IgG glycosylation; CRC cis rs25422 0.938 rs62421538 chr6:118729703 A/T cg10217327 chr6:118973057 C6orf204 0.51 5.71 0.3 2.55e-8 Renal cell carcinoma; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg20824237 chr3:99979579 TBC1D23 0.5 7.05 0.36 1.08e-11 Response to antipsychotic treatment; CRC cis rs6456156 0.742 rs6456157 chr6:167527818 C/A cg19688584 chr6:167529678 CCR6 -0.33 -6.09 -0.32 3.24e-9 Primary biliary cholangitis; CRC cis rs12291225 0.546 rs12291662 chr11:14342949 T/C cg19336497 chr11:14380999 RRAS2 -0.52 -9.14 -0.45 6.61e-18 Sense of smell; CRC cis rs2404602 0.647 rs11631394 chr15:76973209 G/T cg23625390 chr15:77176239 SCAPER -0.88 -14.93 -0.64 7.65e-39 Blood metabolite levels; CRC cis rs7626444 0.625 rs2931210 chr3:196476676 G/C cg12930392 chr3:196481615 PAK2 0.39 6.97 0.36 1.69e-11 Monocyte count; CRC cis rs172166 0.694 rs9295760 chr6:28147385 G/A cg21251018 chr6:28226885 NKAPL 0.47 7.04 0.36 1.13e-11 Cardiac Troponin-T levels; CRC cis rs2949837 0.581 rs2965072 chr7:45980751 G/T cg06713098 chr7:45960367 IGFBP3 0.43 6.83 0.35 4.05e-11 Sitting height ratio; CRC trans rs2235573 0.625 rs8142174 chr22:38427963 C/T cg19894588 chr14:64061835 NA 0.43 6.11 0.32 2.86e-9 Glioblastoma;Glioma; CRC cis rs9911578 0.967 rs8182277 chr17:57144367 C/T cg12560992 chr17:57184187 TRIM37 0.93 17.67 0.7 1.28e-49 Intelligence (multi-trait analysis); CRC cis rs875971 0.508 rs6947808 chr7:66045082 A/G cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.42 -6.27 -0.33 1.13e-9 Aortic root size; CRC cis rs7224685 0.569 rs12947597 chr17:3999199 A/G cg05562828 chr17:3906858 NA -0.44 -5.76 -0.3 1.95e-8 Type 2 diabetes; CRC cis rs8005677 0.798 rs4982713 chr14:23404102 C/T cg25600027 chr14:23388339 RBM23 -0.43 -6.34 -0.33 7.59e-10 Cognitive ability (multi-trait analysis); CRC cis rs1129187 0.755 rs9462855 chr6:42925936 G/C cg05552183 chr6:42928497 GNMT 0.52 7.99 0.4 2.25e-14 Alzheimer's disease in APOE e4+ carriers; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg18143863 chr3:25706824 TOP2B 0.49 6.9 0.36 2.62e-11 Response to antipsychotic treatment; CRC cis rs4974559 0.947 rs6847321 chr4:1347374 C/T cg01733459 chr4:1388830 CRIPAK 0.5 5.79 0.3 1.68e-8 Systolic blood pressure; CRC cis rs709400 1.000 rs55885592 chr14:104126024 C/T cg24130564 chr14:104152367 KLC1 -0.44 -6.61 -0.34 1.54e-10 Body mass index; CRC cis rs10504229 0.861 rs67042991 chr8:58191749 G/C cg24829409 chr8:58192753 C8orf71 -0.68 -11.34 -0.53 2.27e-25 Developmental language disorder (linguistic errors); CRC cis rs116095464 0.558 rs10462755 chr5:246748 T/C cg22857025 chr5:266934 NA -1.25 -16.72 -0.68 7.53e-46 Breast cancer; CRC cis rs7618915 0.570 rs11714088 chr3:52758942 A/C cg18404041 chr3:52824283 ITIH1 -0.43 -8.71 -0.43 1.54e-16 Bipolar disorder; CRC trans rs16957091 0.528 rs72713784 chr15:43115936 A/G cg15973384 chr6:168817498 NA 0.53 6.06 0.32 3.64e-9 MGMT methylation in smokers; CRC cis rs7258465 1.000 rs4595905 chr19:18547305 T/A cg10790698 chr19:18539756 SSBP4 -0.46 -8.72 -0.43 1.44e-16 Breast cancer; CRC cis rs2274273 0.638 rs9919921 chr14:55695505 A/G cg10130446 chr14:55658398 DLGAP5 -0.43 -5.75 -0.3 2.04e-8 Protein biomarker; CRC cis rs1552244 0.882 rs9312044 chr3:10037481 T/C cg18598329 chr3:10140678 FANCD2;C3orf24 -0.83 -11.7 -0.54 1.12e-26 Alzheimer's disease; CRC cis rs7618915 0.547 rs2878726 chr3:52748271 C/G cg07507251 chr3:52567010 NT5DC2 0.44 6.39 0.33 5.81e-10 Bipolar disorder; CRC cis rs12824058 0.831 rs11609362 chr12:130810526 T/C cg24838063 chr12:130822603 PIWIL1 0.58 9.77 0.47 5.67e-20 Menopause (age at onset); CRC cis rs4243830 0.850 rs12030607 chr1:6601007 T/A cg22792644 chr1:6614718 TAS1R1;NOL9 0.89 10.55 0.5 1.3e-22 Body mass index; CRC cis rs3820068 0.603 rs7516453 chr1:15972558 C/G cg13390004 chr1:15929781 NA 0.55 7.43 0.38 9.37e-13 Systolic blood pressure; CRC cis rs7202877 0.561 rs4888369 chr16:75307277 T/C cg03315344 chr16:75512273 CHST6 0.52 5.89 0.31 9.66e-9 Type 2 diabetes;Type 1 diabetes; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg13537857 chr3:133293460 CDV3 0.41 6.23 0.32 1.39e-9 Liver disease severity in Alagille syndrome; CRC cis rs67311347 1.000 rs4974017 chr3:40473519 C/T cg24209194 chr3:40518798 ZNF619 0.45 6.84 0.35 3.85e-11 Renal cell carcinoma; CRC cis rs9326248 0.520 rs6589602 chr11:117037065 T/C cg10130564 chr11:117069849 TAGLN 0.31 5.95 0.31 6.71e-9 Blood protein levels; CRC cis rs7618915 0.547 rs12496476 chr3:52708737 A/G cg07507251 chr3:52567010 NT5DC2 0.46 6.6 0.34 1.68e-10 Bipolar disorder; CRC cis rs3764563 0.799 rs7249233 chr19:15723591 T/C cg20725493 chr19:15740067 CYP4F8 -0.7 -6.45 -0.34 3.96e-10 Inflammatory biomarkers; CRC cis rs7552404 0.924 rs1146579 chr1:76209792 C/T cg03433033 chr1:76189801 ACADM -0.74 -11.14 -0.52 1.14e-24 Blood metabolite levels;Acylcarnitine levels; CRC cis rs172166 0.637 rs1225595 chr6:28151340 A/T cg26587870 chr6:27730563 NA -0.37 -5.76 -0.3 1.96e-8 Cardiac Troponin-T levels; CRC cis rs13108904 0.967 rs1316419 chr4:1293997 C/T cg19318889 chr4:1322082 MAEA 0.4 5.72 0.3 2.39e-8 Obesity-related traits; CRC cis rs951366 0.617 rs823074 chr1:205774839 T/C cg24739457 chr1:205821442 NA 0.44 6.44 0.33 4.18e-10 Menarche (age at onset); CRC cis rs17376456 0.569 rs10050364 chr5:93064127 T/C cg25358565 chr5:93447407 FAM172A 0.65 7.83 0.4 6.68e-14 Diabetic retinopathy; CRC cis rs921968 0.643 rs832802 chr2:219386899 C/T cg02176678 chr2:219576539 TTLL4 0.48 8.0 0.4 2.1e-14 Mean corpuscular hemoglobin concentration; CRC cis rs262150 1.000 rs262149 chr7:158778256 A/G cg10570241 chr7:158785291 NA -0.47 -8.21 -0.41 5.09e-15 Facial morphology (factor 20); CRC cis rs13064447 0.817 rs73022951 chr3:12767557 G/A cg07775309 chr3:12595852 NA 0.35 5.7 0.3 2.63e-8 Major depression and alcohol dependence; CRC trans rs7618501 0.633 rs2856234 chr3:50139142 A/G cg21659725 chr3:3221576 CRBN -0.55 -8.77 -0.44 9.89e-17 Intelligence (multi-trait analysis); CRC cis rs4237845 0.591 rs10747788 chr12:58315338 C/T cg23860436 chr12:58378763 NA 0.37 5.97 0.31 6.23e-9 Intelligence (multi-trait analysis); CRC cis rs3785574 0.962 rs2584632 chr17:61880641 G/A cg23090583 chr17:61904693 PSMC5;FTSJ3 0.66 9.59 0.47 2.2e-19 Height; CRC cis rs10751667 0.666 rs7123912 chr11:963936 T/C cg01483505 chr11:975446 AP2A2 0.46 7.66 0.39 2.11e-13 Alzheimer's disease (late onset); CRC cis rs4713118 0.869 rs10214440 chr6:27702440 A/C cg02683197 chr6:28174875 NA 0.62 8.43 0.42 1.14e-15 Parkinson's disease; CRC cis rs7618915 0.571 rs67539070 chr3:52711974 T/C cg05573699 chr3:52720067 GNL3;PBRM1 -0.47 -6.77 -0.35 6.02e-11 Bipolar disorder; CRC cis rs2072510 0.593 rs2540497 chr12:96404275 A/T cg09636302 chr12:96389483 HAL -0.51 -6.4 -0.33 5.42e-10 Metabolite levels (small molecules and protein measures); CRC cis rs61776719 0.875 rs10890238 chr1:38445654 A/T cg12658694 chr1:38397304 INPP5B 0.56 8.87 0.44 4.87e-17 Coronary artery disease; CRC cis rs7584330 0.826 rs72620824 chr2:238381083 G/A cg14458575 chr2:238380390 NA 0.89 16.32 0.67 2.73e-44 Prostate cancer; CRC cis rs25422 0.938 rs62421538 chr6:118729703 A/T cg22561889 chr6:118971681 C6orf204 0.54 6.92 0.36 2.31e-11 Renal cell carcinoma; CRC cis rs6502050 0.835 rs8075086 chr17:80092649 A/G cg22110888 chr17:80059540 CCDC57 0.4 6.36 0.33 6.79e-10 Life satisfaction; CRC cis rs2688608 0.592 rs12253482 chr10:75496130 G/A cg16540259 chr10:75572220 NDST2 0.38 5.8 0.3 1.59e-8 Inflammatory bowel disease; CRC trans rs916888 0.773 rs199445 chr17:44817408 C/T cg22433210 chr17:43662623 NA 0.92 9.76 0.47 6.41e-20 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs483180 0.511 rs496195 chr1:120207182 A/G cg19096424 chr1:120255104 PHGDH -0.44 -6.36 -0.33 6.91e-10 Macular telangiectasia type 2; CRC cis rs116095464 0.558 rs6869925 chr5:264036 A/G cg22857025 chr5:266934 NA -1.25 -16.78 -0.68 4.42e-46 Breast cancer; CRC cis rs2032447 0.772 rs199754 chr6:25992309 A/G cg03264133 chr6:25882463 NA -0.57 -7.66 -0.39 2.07e-13 Intelligence (multi-trait analysis); CRC cis rs6546324 0.625 rs11126138 chr2:67794476 C/T cg15745817 chr2:67799979 NA -0.54 -9.09 -0.45 9.4e-18 Endometriosis; CRC cis rs9322193 0.847 rs4870054 chr6:150169538 C/T cg00933542 chr6:150070202 PCMT1 0.32 6.15 0.32 2.3e-9 Lung cancer; CRC cis rs9322193 0.884 rs11155675 chr6:150064019 T/C cg05861140 chr6:150128134 PCMT1 -0.39 -6.09 -0.32 3.11e-9 Lung cancer; CRC cis rs6831352 0.918 rs7669636 chr4:100059312 G/A cg12011299 chr4:100065546 ADH4 -0.49 -9.23 -0.45 3.34e-18 Alcohol dependence; CRC cis rs7727544 0.647 rs72793280 chr5:131562900 C/T cg09877947 chr5:131593287 PDLIM4 0.37 6.38 0.33 6.08e-10 Blood metabolite levels; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg16104446 chr8:48873951 MCM4;PRKDC 0.48 6.18 0.32 1.91e-9 Thyroid stimulating hormone; CRC cis rs6502050 0.835 rs7503225 chr17:80099639 C/A cg09264619 chr17:80180166 NA -0.34 -5.81 -0.3 1.5e-8 Life satisfaction; CRC cis rs10751667 0.666 rs7396473 chr11:966181 T/C ch.11.42038R chr11:967971 AP2A2 0.58 9.98 0.48 1.16e-20 Alzheimer's disease (late onset); CRC cis rs172166 0.694 rs1770131 chr6:28086413 C/T cg23161317 chr6:28129485 ZNF389 0.47 6.62 0.34 1.48e-10 Cardiac Troponin-T levels; CRC cis rs7589342 0.899 rs11885225 chr2:106486548 T/C cg16077055 chr2:106428750 NCK2 0.4 5.73 0.3 2.23e-8 Addiction; CRC cis rs763014 0.932 rs2269559 chr16:682297 T/C cg00802000 chr16:706648 WDR90 -0.41 -5.84 -0.31 1.22e-8 Height; CRC cis rs1552244 0.938 rs34750074 chr3:10091740 G/A cg10729496 chr3:10149963 C3orf24 0.53 6.96 0.36 1.8e-11 Alzheimer's disease; CRC cis rs9329221 0.905 rs4610752 chr8:10248962 A/G cg27411982 chr8:10470053 RP1L1 -0.35 -5.68 -0.3 2.99e-8 Neuroticism; CRC cis rs72772090 0.539 rs35898772 chr5:96179685 A/G cg17330273 chr5:96107758 CAST;ERAP1 -0.64 -6.27 -0.33 1.13e-9 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs10504229 0.861 rs59873610 chr8:58172290 T/A cg24829409 chr8:58192753 C8orf71 -0.68 -11.31 -0.53 2.93e-25 Developmental language disorder (linguistic errors); CRC cis rs3008870 0.920 rs3008860 chr1:67391003 G/C cg08660285 chr1:67390436 MIER1;WDR78 1.02 15.14 0.64 1.16e-39 Lymphocyte percentage of white cells; CRC cis rs6502050 0.814 rs62079997 chr17:80076888 C/T cg02741985 chr17:80059408 CCDC57 -0.45 -7.4 -0.38 1.17e-12 Life satisfaction; CRC cis rs9491140 1.000 rs12204812 chr6:124681503 C/A cg19267163 chr6:125004984 NKAIN2 0.36 5.66 0.3 3.24e-8 Neuroticism; CRC cis rs1816752 0.806 rs3816218 chr13:25017171 A/G cg02811702 chr13:24901961 NA 0.48 6.6 0.34 1.69e-10 Obesity-related traits; CRC cis rs6952808 0.717 rs12534679 chr7:1926745 G/A cg22963979 chr7:1858916 MAD1L1 -0.47 -7.66 -0.39 2.15e-13 Bipolar disorder and schizophrenia; CRC cis rs8062405 1.000 rs4788099 chr16:28855727 A/G cg16576597 chr16:28551801 NUPR1 0.48 6.83 0.35 4.24e-11 Cognitive ability (multi-trait analysis);Cognitive ability; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg12194463 chr7:32982580 RP9P 0.48 6.43 0.33 4.61e-10 Anxiety disorder; CRC cis rs780096 0.778 rs780094 chr2:27741237 C/T cg24768116 chr2:27665128 KRTCAP3 0.3 6.61 0.34 1.55e-10 Total body bone mineral density; CRC cis rs2153535 0.580 rs6905237 chr6:8471790 A/T cg07606381 chr6:8435919 SLC35B3 0.69 11.02 0.52 3.05e-24 Motion sickness; CRC cis rs1448094 0.512 rs56082822 chr12:86255475 C/T cg19622623 chr12:86230825 RASSF9 -0.41 -6.59 -0.34 1.7e-10 Major depressive disorder; CRC cis rs875971 0.505 rs2462573 chr7:65507392 C/T cg18876405 chr7:65276391 NA -0.64 -11.51 -0.54 5.4e-26 Aortic root size; CRC cis rs4290604 0.748 rs80326134 chr2:237982015 T/C cg23555395 chr2:238036564 NA 0.68 6.92 0.36 2.36e-11 Asthma; CRC cis rs870825 0.549 rs28579266 chr4:185627262 T/C cg04058563 chr4:185651563 MLF1IP 0.72 9.38 0.46 1.12e-18 Blood protein levels; CRC cis rs10504229 1.000 rs55944282 chr8:58180821 A/G cg05313129 chr8:58192883 C8orf71 -0.47 -6.99 -0.36 1.49e-11 Developmental language disorder (linguistic errors); CRC cis rs9814567 1.000 rs9289478 chr3:134268619 A/G cg06109529 chr3:134205091 CEP63;ANAPC13 -0.8 -11.99 -0.55 9.75e-28 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs3617 0.625 rs2240917 chr3:52851137 T/C cg15147215 chr3:52552868 STAB1 -0.53 -9.29 -0.46 2.18e-18 Red blood cell count;Autism spectrum disorder or schizophrenia; CRC cis rs1799949 1.000 rs34059614 chr17:41303071 C/T cg23758822 chr17:41437982 NA 0.8 13.44 0.6 3.93e-33 Menopause (age at onset); CRC trans rs7615952 0.546 rs2922197 chr3:125322032 G/A cg02560186 chr11:3602584 NA -0.57 -6.97 -0.36 1.73e-11 Blood pressure (smoking interaction); CRC cis rs4474465 0.915 rs7123060 chr11:78208634 A/G cg27205649 chr11:78285834 NARS2 0.48 5.8 0.3 1.56e-8 Alzheimer's disease (survival time); CRC cis rs11191205 0.686 rs10883671 chr10:103413862 G/T cg15320455 chr10:103880129 LDB1 0.57 6.49 0.34 3.23e-10 Intelligence (multi-trait analysis); CRC trans rs7819412 0.595 rs10503416 chr8:10987553 C/T cg16141378 chr3:129829833 LOC729375 -0.45 -6.88 -0.35 3e-11 Triglycerides; CRC cis rs4972806 0.849 rs1542180 chr2:177028767 C/T cg25347419 chr2:177043501 NA 0.58 8.89 0.44 4e-17 IgG glycosylation; CRC trans rs7829975 0.606 rs11776838 chr8:8794801 C/T cg16141378 chr3:129829833 LOC729375 0.42 6.25 0.33 1.25e-9 Mood instability; CRC cis rs3845702 1.000 rs3768837 chr2:180835792 T/A cg23417306 chr2:180868811 CWC22 -0.43 -5.92 -0.31 7.89e-9 Schizophrenia; CRC cis rs4474465 0.688 rs4275650 chr11:78284822 T/A cg27205649 chr11:78285834 NARS2 0.53 6.85 0.35 3.63e-11 Alzheimer's disease (survival time); CRC cis rs7259376 0.934 rs7253315 chr19:22594439 C/T cg02657401 chr19:22469223 NA 0.31 6.82 0.35 4.25e-11 Menopause (age at onset); CRC cis rs7917772 0.565 rs61869210 chr10:104437175 A/C cg11453585 chr10:104263688 ACTR1A;SUFU 0.74 10.31 0.49 8.65e-22 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC cis rs3862260 0.509 rs10802124 chr1:120164252 G/A cg16322792 chr1:120165303 ZNF697 0.47 8.16 0.41 7.34e-15 Systemic lupus erythematosus; CRC cis rs10751667 0.666 rs6597960 chr11:977036 C/T cg01483505 chr11:975446 AP2A2 0.46 7.66 0.39 2.11e-13 Alzheimer's disease (late onset); CRC cis rs853679 0.550 rs1225599 chr6:28165190 C/T cg02683197 chr6:28174875 NA 0.88 12.35 0.56 4.59e-29 Depression; CRC cis rs3126085 0.935 rs2338430 chr1:152214420 C/T cg09127314 chr1:152161683 NA -0.47 -6.05 -0.32 3.84e-9 Atopic dermatitis; CRC cis rs7666738 1.000 rs880471 chr4:98922541 C/T cg03676636 chr4:99064102 C4orf37 0.22 6.19 0.32 1.83e-9 Colonoscopy-negative controls vs population controls; CRC cis rs4547160 0.821 rs877898 chr12:63483535 G/A cg26727693 chr12:63544175 AVPR1A -0.41 -7.45 -0.38 8.23e-13 Morning vs. evening chronotype; CRC cis rs9469890 0.604 rs11758426 chr6:34503338 A/G cg14254433 chr6:34482411 PACSIN1 -0.45 -5.63 -0.3 3.9e-8 Pubertal anthropometrics;Coronary artery disease; CRC cis rs9649213 0.574 rs60077733 chr7:97970137 C/T cg24562669 chr7:97807699 LMTK2 0.46 7.58 0.39 3.61e-13 Prostate cancer (SNP x SNP interaction); CRC cis rs17270561 0.609 rs7754296 chr6:25744878 A/G cg16482183 chr6:26056742 HIST1H1C 0.82 10.46 0.5 2.62e-22 Iron status biomarkers; CRC cis rs2976388 0.507 rs13259549 chr8:143838519 T/C cg05569086 chr8:143859399 LYNX1 0.52 8.95 0.44 2.69e-17 Urinary tract infection frequency; CRC cis rs12612619 0.732 rs11126836 chr2:27273128 C/T cg00617064 chr2:27272375 NA -0.39 -6.46 -0.34 3.71e-10 Venous thromboembolism adjusted for sickle cell variant rs77121243-T; CRC cis rs10744422 0.843 rs3896870 chr12:123333611 T/C cg25930673 chr12:123319894 HIP1R -0.59 -6.23 -0.32 1.41e-9 Schizophrenia; CRC cis rs4909189 1.000 rs12698214 chr7:158136204 T/G cg06219351 chr7:158114137 PTPRN2 -0.6 -8.23 -0.41 4.32e-15 Response to amphetamines; CRC cis rs78456975 1.000 rs13392535 chr2:1542634 G/T cg12573674 chr2:1569213 NA -0.73 -7.36 -0.38 1.5e-12 Placebo response in major depressive disorder (% change in symptom score); CRC cis rs2072510 0.569 rs7306086 chr12:96390502 T/C cg09636302 chr12:96389483 HAL -0.52 -6.5 -0.34 3.02e-10 Metabolite levels (small molecules and protein measures); CRC trans rs6598955 0.585 rs11577098 chr1:26602525 C/T cg07461501 chr17:79650226 HGS;ARL16 -0.52 -6.19 -0.32 1.77e-9 Obesity-related traits; CRC cis rs28386778 0.897 rs2044125 chr17:61863184 A/C cg22520471 chr17:61851767 DDX42;CCDC47 -0.72 -11.22 -0.53 6.06e-25 Prudent dietary pattern; CRC cis rs11123610 0.520 rs11682697 chr2:3721127 A/G cg10645314 chr2:3704589 ALLC -0.54 -6.39 -0.33 5.78e-10 Response to inhaled corticosteroid treatment in asthma (change in FEV1); CRC cis rs3820928 0.904 rs2396431 chr2:227765488 G/A cg11843606 chr2:227700838 RHBDD1 -0.41 -5.87 -0.31 1.05e-8 Pulmonary function; CRC cis rs6557786 0.636 rs17052934 chr8:24840319 A/C cg14988396 chr8:25316392 CDCA2;KCTD9 0.44 5.88 0.31 1.02e-8 Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 2 peripheral neuropathy); CRC cis rs738322 0.753 rs5756968 chr22:38595240 C/T cg25457927 chr22:38595422 NA 0.51 11.53 0.54 4.46e-26 Cutaneous nevi; CRC cis rs7493 0.755 rs17886036 chr7:94987727 C/A cg04155289 chr7:94953770 PON1 -0.57 -7.1 -0.36 7.66e-12 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs17401966 0.522 rs6541085 chr1:10285709 A/G cg19773385 chr1:10388646 KIF1B -0.49 -7.76 -0.39 1.05e-13 Hepatocellular carcinoma; CRC trans rs6951245 1.000 rs11761941 chr7:1097183 G/A cg13565492 chr6:43139072 SRF -0.72 -7.44 -0.38 8.63e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs10078 0.571 rs890973 chr5:471494 T/C cg07599136 chr5:415885 AHRR 0.68 6.74 0.35 7.29e-11 Fat distribution (HIV); CRC cis rs7528419 0.617 rs4970834 chr1:109814880 C/T cg00908766 chr1:109817496 CELSR2 -0.33 -5.83 -0.31 1.33e-8 Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease);Myocardial infarction;Lipoprotein-associated phospholipase A2 activity and mass;Lipoprotein-associated phospholipase A2 activity change in response to darapladib treatment in cardiovascular disease;Cholesterol, total;Coronary artery disease; CRC cis rs7258465 0.965 rs8100767 chr19:18589088 T/C cg01065977 chr19:18549689 ISYNA1 -0.41 -6.39 -0.33 5.59e-10 Breast cancer; CRC cis rs10504229 0.683 rs11785258 chr8:58132893 A/G cg22535103 chr8:58192502 C8orf71 -0.7 -9.34 -0.46 1.47e-18 Developmental language disorder (linguistic errors); CRC cis rs1799949 0.930 rs3092987 chr17:41222723 T/C cg05368731 chr17:41323189 NBR1 0.66 9.66 0.47 1.33e-19 Menopause (age at onset); CRC cis rs6860806 0.603 rs112300250 chr5:131583292 G/A cg11843238 chr5:131593191 PDLIM4 0.43 8.18 0.41 6.26e-15 Breast cancer; CRC cis rs72634258 0.842 rs7545745 chr1:8165667 T/A cg00042356 chr1:8021962 PARK7 -0.54 -6.27 -0.33 1.14e-9 Inflammatory bowel disease; CRC cis rs11098499 0.954 rs3733523 chr4:120423719 C/T cg09307838 chr4:120376055 NA 0.71 10.96 0.52 5.0600000000000004e-24 Corneal astigmatism; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg00960509 chr1:21671908 ECE1 -0.45 -6.82 -0.35 4.26e-11 Myopia (pathological); CRC cis rs4862750 0.872 rs13110072 chr4:187878524 A/G cg11301795 chr4:187892539 NA -0.85 -19.37 -0.73 2.52e-56 Lobe attachment (rater-scored or self-reported); CRC cis rs6963495 0.719 rs73190172 chr7:105161210 T/C cg02135003 chr7:105160482 PUS7 -0.9 -12.2 -0.56 1.71e-28 Bipolar disorder (body mass index interaction); CRC cis rs7917772 0.619 rs2251772 chr10:104470918 T/C cg11453585 chr10:104263688 ACTR1A;SUFU 0.81 11.2 0.53 6.88e-25 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC cis rs2239547 0.603 rs71301807 chr3:53085475 C/G cg18404041 chr3:52824283 ITIH1 -0.32 -5.66 -0.3 3.23e-8 Schizophrenia; CRC trans rs116095464 0.558 rs6878087 chr5:223117 C/T cg00938859 chr5:1591904 SDHAP3 -0.57 -6.22 -0.32 1.51e-9 Breast cancer; CRC cis rs1448094 0.512 rs7313278 chr12:86250263 C/T cg25456477 chr12:86230367 RASSF9 0.34 5.99 0.31 5.54e-9 Major depressive disorder; CRC cis rs9914988 0.943 rs2874253 chr17:27157863 A/T cg16670446 chr17:27188758 MIR451;MIR144 0.53 8.4 0.42 1.32e-15 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs7845219 0.525 rs10956931 chr8:95930301 A/G cg16049864 chr8:95962084 TP53INP1 -0.39 -6.1 -0.32 2.99e-9 Type 2 diabetes; CRC trans rs2303319 0.504 rs35304298 chr2:162617185 G/T cg22988483 chr14:93581567 ITPK1 -0.66 -6.08 -0.32 3.32e-9 Cognitive function; CRC trans rs800082 0.671 rs800099 chr3:144398547 A/T cg24215973 chr2:240111563 HDAC4 -0.77 -10.3 -0.49 9.87e-22 Smoking behavior; CRC trans rs8175379 0.521 rs10037109 chr5:46328445 C/G cg11378101 chr11:94826095 ENDOD1 -0.21 -6.07 -0.32 3.56e-9 Interleukin-7 levels; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg19482049 chr3:30647725 TGFBR2 0.38 6.81 0.35 4.6e-11 Intelligence (multi-trait analysis); CRC cis rs672059 1.000 rs479994 chr1:183161729 C/T ch.1.3577855R chr1:183094577 LAMC1 0.5 7.28 0.37 2.41e-12 Hypertriglyceridemia; CRC cis rs9372498 0.536 rs55697388 chr6:118891544 C/T cg10217327 chr6:118973057 C6orf204 0.52 5.87 0.31 1.08e-8 Diastolic blood pressure; CRC cis rs10504229 0.639 rs16921812 chr8:58106737 C/T cg24829409 chr8:58192753 C8orf71 -0.56 -8.01 -0.4 2.05e-14 Developmental language disorder (linguistic errors); CRC cis rs2160860 0.965 rs2543046 chr8:39819370 A/C cg11363097 chr8:39792086 IDO2 -0.36 -5.75 -0.3 2.08e-8 Blood metabolite levels; CRC cis rs2976388 0.578 rs13254358 chr8:143823876 G/A cg05569086 chr8:143859399 LYNX1 -0.39 -6.11 -0.32 2.74e-9 Urinary tract infection frequency; CRC cis rs11212617 0.934 rs623860 chr11:108106782 C/T cg01991180 chr11:108092276 ATM;NPAT 0.39 5.6 0.3 4.42e-8 Response to metformin in type 2 diabetes (glycemic); CRC cis rs554111 0.656 rs3121071 chr1:21128420 C/T cg02927042 chr1:21476669 EIF4G3 0.38 5.68 0.3 2.98e-8 Facial morphology (factor 17, height of vermillion upper lip); CRC cis rs6088580 0.634 rs6088484 chr20:32985961 T/C cg24642439 chr20:33292090 TP53INP2 -0.37 -6.31 -0.33 8.83e-10 Glomerular filtration rate (creatinine); CRC trans rs16924631 0.769 rs13292799 chr9:6448764 A/G cg18105767 chr19:41698548 CYP2S1 -0.46 -6.0 -0.31 5.18e-9 Periodontal microbiota; CRC cis rs78456975 0.941 rs13412229 chr2:1520381 C/T cg12573674 chr2:1569213 NA -0.71 -7.0 -0.36 1.41e-11 Placebo response in major depressive disorder (% change in symptom score); CRC cis rs2070488 1.000 rs13089394 chr3:38446309 C/A cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.89 16.32 0.67 2.89e-44 Electrocardiographic conduction measures; CRC cis rs599083 0.530 rs583545 chr11:68178635 T/C cg16797656 chr11:68205561 LRP5 -0.41 -6.55 -0.34 2.28e-10 Bone mineral density (spine); CRC cis rs300703 0.639 rs397719 chr2:204870 T/G cg21211680 chr2:198530 NA 0.9 12.04 0.55 6.54e-28 Blood protein levels; CRC cis rs7113874 0.589 rs7949017 chr11:8492127 C/T cg20771178 chr11:8615675 STK33 0.34 5.67 0.3 3.07e-8 Body mass index in physically active individuals;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs908922 0.676 rs4845443 chr1:152507156 C/T cg23254163 chr1:152506842 NA 0.52 10.37 0.5 5.45e-22 Hair morphology; CRC cis rs77106637 0.769 rs11603313 chr11:72588177 G/A cg03713592 chr11:72463424 ARAP1 0.71 7.01 0.36 1.38e-11 Type 2 diabetes; CRC cis rs72615157 0.645 rs76281814 chr7:99846414 T/C cg19337854 chr7:99768885 GPC2 0.47 5.93 0.31 7.64e-9 Lung function (FEV1/FVC); CRC cis rs78456975 0.628 rs13426896 chr2:1554768 C/T cg26248373 chr2:1572462 NA -0.67 -7.62 -0.39 2.8e-13 Placebo response in major depressive disorder (% change in symptom score); CRC cis rs11122272 0.735 rs2808584 chr1:231512925 A/G cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.54 -8.11 -0.41 1.04e-14 Hemoglobin concentration; CRC trans rs1814175 0.519 rs10839291 chr11:49514321 G/A cg15704280 chr7:45808275 SEPT13 0.76 10.04 0.48 7.3e-21 Height; CRC cis rs12188164 0.900 rs72717425 chr5:438809 C/T cg26850624 chr5:429559 AHRR -0.74 -12.46 -0.57 1.83e-29 Cystic fibrosis severity; CRC cis rs2404602 0.716 rs56351018 chr15:76824591 T/C cg03037974 chr15:76606532 NA 0.71 12.35 0.56 4.72e-29 Blood metabolite levels; CRC cis rs13161895 1.000 rs4129403 chr5:179476610 A/G cg02702477 chr5:179499311 RNF130 0.61 6.95 0.36 1.95e-11 LDL cholesterol; CRC cis rs2279817 0.863 rs1416854 chr1:18024675 G/A cg21791023 chr1:18019539 ARHGEF10L 0.49 6.03 0.32 4.33e-9 Neuroticism; CRC cis rs7772486 0.790 rs2253654 chr6:146199445 T/C cg23711669 chr6:146136114 FBXO30 0.74 12.97 0.58 2.31e-31 Lobe attachment (rater-scored or self-reported); CRC cis rs875971 0.893 rs62465470 chr7:65601218 T/C cg18876405 chr7:65276391 NA -0.5 -8.26 -0.41 3.52e-15 Aortic root size; CRC cis rs12971120 0.891 rs12968731 chr18:72169708 G/T cg26446133 chr18:72167187 CNDP2 -0.74 -11.13 -0.52 1.21e-24 Refractive error; CRC cis rs7312933 1.000 rs10880230 chr12:42450253 G/A cg17420585 chr12:42539391 GXYLT1 -0.43 -6.28 -0.33 1.09e-9 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CRC cis rs9650657 0.537 rs7016385 chr8:10779472 A/G cg27411982 chr8:10470053 RP1L1 0.43 6.35 0.33 7.29e-10 Neuroticism; CRC trans rs7267979 1.000 rs6037121 chr20:25428311 G/A cg17903999 chr18:56338584 MALT1 -0.42 -6.98 -0.36 1.6e-11 Liver enzyme levels (alkaline phosphatase); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg24555065 chr12:6977392 TPI1 0.49 7.0 0.36 1.46e-11 Response to antipsychotic treatment; CRC cis rs78523330 0.614 rs78443405 chr17:37072073 G/A cg21637561 chr17:37074902 LASP1 -0.63 -5.74 -0.3 2.18e-8 Multiple system atrophy; CRC cis rs2732480 0.500 rs1552550 chr12:48643351 C/A cg24011408 chr12:48396354 COL2A1 0.46 6.48 0.34 3.4e-10 Hemoglobin concentration;Red blood cell count;Hematocrit; CRC cis rs4970988 0.556 rs2280078 chr1:150600181 C/T cg17724175 chr1:150552817 MCL1 -0.67 -11.24 -0.53 5.04e-25 Urate levels; CRC cis rs240764 0.555 rs4840150 chr6:101183774 T/C cg09795085 chr6:101329169 ASCC3 0.42 5.81 0.31 1.44e-8 Neuroticism; CRC cis rs4843747 0.671 rs72818577 chr16:88111181 G/A cg07865391 chr16:88106882 BANP 0.43 5.69 0.3 2.87e-8 Menopause (age at onset); CRC trans rs561341 0.882 rs2428337 chr17:30299467 C/T cg27661571 chr11:113659931 NA -0.96 -11.11 -0.52 1.42e-24 Hip circumference adjusted for BMI; CRC cis rs2882667 0.898 rs6862393 chr5:138364698 T/C cg04439458 chr5:138467593 SIL1 -0.33 -5.99 -0.31 5.45e-9 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs4665809 0.878 rs4665826 chr2:26367503 A/T cg22920501 chr2:26401640 FAM59B 0.69 8.94 0.44 2.94e-17 Gut microbiome composition (summer); CRC cis rs4713118 0.662 rs149948 chr6:27974817 C/G cg23485639 chr6:28045615 ZNF165 0.39 5.73 0.3 2.24e-8 Parkinson's disease; CRC cis rs6691722 0.503 rs6656485 chr1:24707685 A/G cg18323236 chr1:24743029 NIPAL3 0.39 5.68 0.3 2.96e-8 Response to interferon beta in multiple sclerosis; CRC cis rs6502050 0.835 rs4499294 chr17:80148346 C/T cg19223190 chr17:80058835 NA 0.39 6.21 0.32 1.62e-9 Life satisfaction; CRC cis rs4713118 0.597 rs172166 chr6:28020820 C/G cg25164649 chr6:28176230 NA 0.64 8.67 0.43 1.95e-16 Parkinson's disease; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg15380588 chr6:144606480 NA 0.37 6.13 0.32 2.49e-9 Liver disease severity in Alagille syndrome; CRC cis rs11098499 0.954 rs6820115 chr4:120398182 T/C cg09307838 chr4:120376055 NA 0.68 10.91 0.52 7.48e-24 Corneal astigmatism; CRC cis rs6684514 1.000 rs12122180 chr1:156244559 G/A cg16558208 chr1:156270281 VHLL 0.59 9.2 0.45 4.08e-18 Mean corpuscular hemoglobin concentration;Glycated hemoglobin levels; CRC cis rs16975963 0.843 rs1056405 chr19:38313021 T/C cg15135657 chr19:38346511 NA -0.44 -5.94 -0.31 7.12e-9 Longevity; CRC cis rs10791323 0.601 rs7946883 chr11:133733864 T/C cg15485101 chr11:133734466 NA 0.47 8.47 0.42 8.06e-16 Childhood ear infection; CRC cis rs10504229 1.000 rs74546828 chr8:58171678 A/G cg24829409 chr8:58192753 C8orf71 -0.68 -11.34 -0.53 2.27e-25 Developmental language disorder (linguistic errors); CRC cis rs16975963 0.644 rs112666969 chr19:38047645 G/A cg15135657 chr19:38346511 NA -0.42 -5.98 -0.31 5.91e-9 Longevity; CRC cis rs1046896 0.594 rs9914570 chr17:80783721 C/T cg02711726 chr17:80685570 FN3KRP -0.55 -7.35 -0.38 1.58e-12 Glycated hemoglobin levels; CRC cis rs10992471 0.756 rs1121979 chr9:95140218 G/A cg13798575 chr9:95087839 CENPP;NOL8 -0.48 -6.97 -0.36 1.79e-11 Visceral adipose tissue/subcutaneous adipose tissue ratio; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg08448040 chr3:13521693 HDAC11 0.48 6.19 0.32 1.82e-9 Thyroid stimulating hormone; CRC cis rs7249142 0.549 rs2238667 chr19:19282523 G/A cg08207377 chr19:19281140 LOC729991-MEF2B;MEF2B -0.38 -6.11 -0.32 2.75e-9 IgG glycosylation; CRC cis rs9786986 0.764 rs2492767 chr1:235695799 A/G cg08848088 chr1:235714526 GNG4 0.49 5.91 0.31 8.35e-9 Body mass index; CRC trans rs9858542 0.953 rs35169793 chr3:49423274 A/G cg21659725 chr3:3221576 CRBN -0.65 -8.96 -0.44 2.56e-17 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg10893370 chr17:30228961 UTP6 0.42 6.13 0.32 2.49e-9 Intelligence (multi-trait analysis); CRC cis rs9905704 0.708 rs304263 chr17:56749941 C/T cg12560992 chr17:57184187 TRIM37 0.57 8.27 0.42 3.25e-15 Testicular germ cell tumor; CRC cis rs55702914 0.809 rs2376407 chr2:198183465 A/G cg03934865 chr2:198174659 NA -0.4 -7.01 -0.36 1.35e-11 Major depression and alcohol dependence; CRC cis rs4285028 0.603 rs79312528 chr3:121608997 T/C cg11130432 chr3:121712080 ILDR1 -0.48 -5.95 -0.31 6.91e-9 Multiple sclerosis; CRC cis rs9660992 0.762 rs1172129 chr1:205244972 T/A cg21643547 chr1:205240462 TMCC2 -0.47 -7.8 -0.4 8.33e-14 Mean corpuscular volume;Mean platelet volume; CRC cis rs10905065 0.829 rs6602278 chr10:5868361 A/G cg11519256 chr10:5708881 ASB13 -0.47 -6.76 -0.35 6.15e-11 Menopause (age at onset); CRC cis rs6502050 0.731 rs9891378 chr17:80116035 T/C cg02741985 chr17:80059408 CCDC57 0.43 7.18 0.37 4.56e-12 Life satisfaction; CRC cis rs10504229 0.610 rs6993531 chr8:58147283 A/G cg24829409 chr8:58192753 C8orf71 -0.52 -8.15 -0.41 7.84e-15 Developmental language disorder (linguistic errors); CRC cis rs2486012 1.000 rs2906459 chr1:44335657 A/C cg12908607 chr1:44402522 ARTN -0.42 -5.71 -0.3 2.53e-8 Intelligence (multi-trait analysis); CRC cis rs6582630 0.519 rs7294292 chr12:38349540 C/T cg13010199 chr12:38710504 ALG10B 0.47 6.3 0.33 9.67e-10 Drug-induced liver injury (flucloxacillin); CRC cis rs294883 0.739 rs9457589 chr6:159733016 C/T cg14500486 chr6:159655392 FNDC1 -0.37 -6.43 -0.33 4.47e-10 Coronary artery disease; CRC cis rs7089973 0.872 rs7075888 chr10:116627117 C/T cg23260525 chr10:116636907 FAM160B1 0.31 6.75 0.35 6.66e-11 Bipolar disorder or attention deficit hyperactivity disorder; CRC cis rs9625935 0.518 rs9614086 chr22:30259608 A/C cg01021169 chr22:30184971 ASCC2 0.37 5.68 0.3 2.92e-8 Tonsillectomy; CRC cis rs13256369 0.708 rs11249886 chr8:8562021 T/A cg06636001 chr8:8085503 FLJ10661 0.49 6.24 0.33 1.31e-9 Obesity-related traits; CRC cis rs2882667 0.898 rs13182437 chr5:138387149 T/C cg04439458 chr5:138467593 SIL1 -0.33 -5.99 -0.31 5.47e-9 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs908922 0.573 rs7544564 chr1:152527007 A/C cg09873164 chr1:152488093 CRCT1 0.37 6.26 0.33 1.19e-9 Hair morphology; CRC cis rs2629540 0.781 rs11245362 chr10:126458649 T/C cg08799069 chr10:126477246 METTL10 -0.62 -8.57 -0.43 4.17e-16 Cocaine dependence; CRC cis rs826838 0.868 rs864324 chr12:39122853 A/G cg26384229 chr12:38710491 ALG10B 0.55 7.78 0.39 9.75e-14 Heart rate; CRC cis rs2882667 0.931 rs11955952 chr5:138329119 A/G cg09476006 chr5:138032270 NA 0.42 7.09 0.36 8.32e-12 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs1976403 0.659 rs10799701 chr1:21820990 A/G cg17800788 chr1:21766015 NBPF3 0.37 6.59 0.34 1.79e-10 Liver enzyme levels (alkaline phosphatase); CRC trans rs7395662 1.000 rs6485907 chr11:48651695 A/G cg21153622 chr11:89784906 NA -0.48 -7.77 -0.39 1e-13 HDL cholesterol; CRC cis rs1005277 0.505 rs719569 chr10:38154415 T/G cg00409905 chr10:38381863 ZNF37A 0.62 10.23 0.49 1.67e-21 Extrinsic epigenetic age acceleration; CRC cis rs8060686 0.641 rs75796305 chr16:68208791 A/G cg08314208 chr16:67682810 RLTPR -0.54 -5.88 -0.31 1.01e-8 HDL cholesterol;Metabolic syndrome; CRC cis rs4722166 0.630 rs1829927 chr7:22779918 G/A cg26061582 chr7:22766209 IL6 0.55 8.35 0.42 1.92e-15 Lung cancer; CRC trans rs916888 0.779 rs199528 chr17:44843136 C/T cg13957321 chr17:43675089 NA 0.53 6.32 0.33 8.34e-10 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC trans rs7829975 0.572 rs28730413 chr8:8795447 A/C cg16141378 chr3:129829833 LOC729375 0.45 6.49 0.34 3.17e-10 Mood instability; CRC cis rs11112613 0.653 rs59504344 chr12:105950837 C/T cg03607813 chr12:105948248 NA 0.79 10.86 0.51 1.08e-23 Corrected insulin response;Corrected insulin response adjusted for insulin sensitivity index; CRC cis rs514406 0.758 rs532242 chr1:53308665 C/G cg08859206 chr1:53392774 SCP2 -0.44 -6.82 -0.35 4.31e-11 Monocyte count; CRC cis rs4654899 0.965 rs17418249 chr1:21390582 C/T cg02927042 chr1:21476669 EIF4G3 -0.49 -7.72 -0.39 1.45e-13 Superior frontal gyrus grey matter volume; CRC cis rs7274811 0.625 rs293722 chr20:31927361 C/T cg07470512 chr20:32255052 NECAB3;C20orf134 -0.42 -5.61 -0.3 4.33e-8 Height; CRC cis rs35306767 0.953 rs10904583 chr10:983498 T/C cg20503657 chr10:835505 NA 0.74 9.41 0.46 8.99e-19 Eosinophil percentage of granulocytes; CRC cis rs2346177 0.519 rs2121698 chr2:46709571 C/T cg02822958 chr2:46747628 ATP6V1E2 0.41 5.83 0.31 1.33e-8 HDL cholesterol; CRC trans rs7613875 0.580 rs12634780 chr3:50043341 A/T cg21659725 chr3:3221576 CRBN -0.46 -6.83 -0.35 4.19e-11 Body mass index; CRC cis rs7914558 0.966 rs3758543 chr10:104944744 C/G cg15744005 chr10:104629667 AS3MT -0.34 -7.2 -0.37 4.18e-12 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC trans rs6951245 0.745 rs79788515 chr7:1101079 C/T cg13565492 chr6:43139072 SRF -0.71 -7.3 -0.37 2.12e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs6681460 0.866 rs996123 chr1:67025343 T/C cg02459107 chr1:67143332 SGIP1 0.46 7.45 0.38 8.5e-13 Presence of antiphospholipid antibodies; CRC cis rs9291683 0.527 rs3822241 chr4:10094931 G/A cg11266682 chr4:10021025 SLC2A9 -0.48 -9.28 -0.46 2.42e-18 Bone mineral density; CRC cis rs9858542 0.953 rs9818590 chr3:49525096 A/G cg00383909 chr3:49044727 WDR6 0.44 5.68 0.3 2.91e-8 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs1707322 0.721 rs4415615 chr1:46132109 C/T cg03146154 chr1:46216737 IPP 0.66 9.65 0.47 1.44e-19 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC trans rs1814175 0.646 rs61904497 chr11:49883449 A/T cg11707556 chr5:10655725 ANKRD33B -0.52 -10.01 -0.48 9.28e-21 Height; CRC cis rs5750830 0.649 rs5757659 chr22:39812409 A/C cg11247378 chr22:39784982 NA -0.41 -7.1 -0.36 7.58e-12 Intelligence (multi-trait analysis); CRC cis rs7119 0.717 rs12902852 chr15:77809016 C/G cg27398640 chr15:77910606 LINGO1 -0.43 -7.35 -0.38 1.55e-12 Type 2 diabetes; CRC cis rs10883723 0.810 rs1056857 chr10:104240003 C/T cg22532475 chr10:104410764 TRIM8 -0.34 -5.86 -0.31 1.11e-8 Allergic disease (asthma, hay fever or eczema); CRC cis rs2573652 0.723 rs2573655 chr15:100515709 A/C cg09918751 chr15:100517450 ADAMTS17 -0.38 -5.76 -0.3 1.97e-8 Height; CRC cis rs35883536 1.000 rs34441740 chr1:101137046 C/G cg14515779 chr1:101123966 NA -0.41 -7.97 -0.4 2.69e-14 Monocyte count; CRC cis rs9921222 0.565 rs10903014 chr16:377623 A/G cg10349874 chr16:420996 TMEM8A;MRPL28 -0.46 -6.22 -0.32 1.49e-9 Bone mineral density (spine);Bone mineral density; CRC cis rs10256972 0.616 rs6957733 chr7:1106327 T/G cg18402987 chr7:1209562 NA 0.44 6.76 0.35 6.36e-11 Longevity;Endometriosis; CRC cis rs2404602 0.647 rs55778276 chr15:77136590 T/A cg03037974 chr15:76606532 NA -0.53 -7.45 -0.38 8.14e-13 Blood metabolite levels; CRC cis rs6570726 0.935 rs399169 chr6:145836353 C/A cg23711669 chr6:146136114 FBXO30 0.68 12.16 0.56 2.33e-28 Lobe attachment (rater-scored or self-reported); CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg12044889 chr6:3000430 NQO2 0.47 6.18 0.32 1.93e-9 Thyroid stimulating hormone; CRC cis rs4689388 0.819 rs12649341 chr4:6294759 G/A cg14416269 chr4:6271139 WFS1 0.4 6.59 0.34 1.72e-10 Type 2 diabetes and other traits;Type 2 diabetes; CRC cis rs1355223 1.000 rs11601205 chr11:34768479 C/T cg11058730 chr11:34937778 PDHX;APIP -0.49 -6.94 -0.36 2.06e-11 Systemic lupus erythematosus and Systemic sclerosis; CRC cis rs7618915 0.547 rs2336542 chr3:52710636 A/G cg08222913 chr3:52553049 STAB1 -0.34 -6.23 -0.32 1.45e-9 Bipolar disorder; CRC cis rs4731207 0.564 rs13234634 chr7:124676033 G/A cg23710748 chr7:124431027 NA -0.43 -6.72 -0.35 8e-11 Cutaneous malignant melanoma; CRC cis rs7538876 0.903 rs1324367 chr1:17752451 C/G cg07965774 chr1:17746286 RCC2 0.32 5.99 0.31 5.59e-9 Basal cell carcinoma; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg20633339 chr19:10196919 C19orf66 0.4 6.5 0.34 2.96e-10 Liver disease severity in Alagille syndrome; CRC cis rs10927875 0.631 rs945418 chr1:16344730 T/C cg22431228 chr1:16359049 CLCNKA -0.44 -7.77 -0.39 1e-13 Dilated cardiomyopathy; CRC cis rs11098499 0.739 rs10013032 chr4:120149419 C/T cg24375607 chr4:120327624 NA -0.46 -7.73 -0.39 1.31e-13 Corneal astigmatism; CRC cis rs4638749 0.677 rs6741222 chr2:108841082 A/G cg25838818 chr2:108905173 SULT1C2 -0.34 -5.72 -0.3 2.33e-8 Blood pressure; CRC cis rs4629710 0.545 rs2077490 chr6:131554184 C/T cg12606694 chr6:131520996 AKAP7 0.54 8.05 0.41 1.52e-14 Multiple myeloma (IgH translocation); CRC cis rs9926296 0.585 rs8058009 chr16:89856439 G/A cg27121462 chr16:89883253 FANCA 0.49 7.29 0.37 2.4e-12 Vitiligo; CRC cis rs372883 0.597 rs2018956 chr21:30736622 C/A cg24692254 chr21:30365293 RNF160 0.46 6.74 0.35 7.11e-11 Pancreatic cancer; CRC cis rs6988985 0.765 rs4483134 chr8:143978646 G/C cg10324643 chr8:143916377 GML 0.38 6.27 0.33 1.15e-9 Plasma androstenedione levels in resected early stage-receptor positive breast cancer; CRC cis rs4819052 0.851 rs9754134 chr21:46661751 T/C cg19498844 chr21:46707878 POFUT2;LOC642852 0.77 10.99 0.52 3.97e-24 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs6500395 0.928 rs12934788 chr16:48706343 C/A cg04672837 chr16:48644449 N4BP1 -0.46 -6.81 -0.35 4.66e-11 Response to tocilizumab in rheumatoid arthritis; CRC trans rs7615952 0.611 rs2971298 chr3:125602713 G/A cg07211511 chr3:129823064 LOC729375 -1.04 -13.84 -0.61 1.2e-34 Blood pressure (smoking interaction); CRC cis rs4481887 0.927 rs10888340 chr1:248440381 C/T cg13385794 chr1:248469461 NA 0.4 6.9 0.36 2.64e-11 Common traits (Other); CRC cis rs17767392 0.881 rs35680546 chr14:71940619 A/G cg13720639 chr14:72061746 SIPA1L1 -0.57 -7.23 -0.37 3.46e-12 Mitral valve prolapse; CRC cis rs7829975 0.522 rs6601689 chr8:8172283 C/T cg06636001 chr8:8085503 FLJ10661 0.56 8.51 0.42 6.42e-16 Mood instability; CRC cis rs798554 1.000 rs798559 chr7:2758341 T/C cg17321639 chr7:2759063 NA -0.54 -7.52 -0.38 5.17e-13 Height; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg18002905 chr4:8442565 ACOX3 0.46 6.48 0.34 3.29e-10 Response to antipsychotic treatment; CRC cis rs11148252 0.514 rs2296347 chr13:52728423 A/C cg12458913 chr13:53173898 NA -0.4 -5.7 -0.3 2.7e-8 Lewy body disease; CRC cis rs763014 0.966 rs12935215 chr16:670605 T/C cg00908189 chr16:619842 PIGQ 0.68 11.22 0.53 5.68e-25 Height; CRC cis rs2067615 0.524 rs9804754 chr12:107083031 G/A cg13491945 chr12:107078410 RFX4 0.36 6.17 0.32 1.96e-9 Heart rate; CRC trans rs9858542 0.953 rs1801143 chr3:49570200 C/T cg21665057 chr3:196295764 WDR53;FBXO45 -0.65 -8.88 -0.44 4.54e-17 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs7412746 0.571 rs12402939 chr1:150615094 A/C cg18016565 chr1:150552671 MCL1 0.48 6.91 0.36 2.57e-11 Melanoma; CRC cis rs992157 0.835 rs2292555 chr2:219146882 G/C cg04880052 chr2:219191631 PNKD -0.44 -6.96 -0.36 1.91e-11 Colorectal cancer; CRC trans rs561341 1.000 rs68140514 chr17:30335781 T/C cg20587970 chr11:113659929 NA -1.18 -16.76 -0.68 5.1e-46 Hip circumference adjusted for BMI; CRC cis rs910316 0.737 rs175424 chr14:75626257 T/C cg03030879 chr14:75389066 RPS6KL1 0.39 5.94 0.31 7.3e-9 Height; CRC cis rs1865760 0.865 rs9467652 chr6:25959127 A/G cg16482183 chr6:26056742 HIST1H1C 0.54 7.99 0.4 2.27e-14 Height; CRC cis rs826838 1.000 rs1843881 chr12:38733706 A/G cg26384229 chr12:38710491 ALG10B -0.74 -10.57 -0.5 1.16e-22 Heart rate; CRC cis rs2243480 1.000 rs316334 chr7:65602126 G/T cg18252515 chr7:66147081 NA -1.25 -14.84 -0.63 1.63e-38 Diabetic kidney disease; CRC cis rs13191362 1.000 rs1333963 chr6:163192571 A/G cg21926612 chr6:163149169 PACRG;PARK2 0.98 12.65 0.57 3.56e-30 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs875971 0.895 rs10447522 chr7:65796074 A/G cg18252515 chr7:66147081 NA 0.42 5.93 0.31 7.79e-9 Aortic root size; CRC cis rs28386778 0.897 rs7501614 chr17:61802612 T/C cg22520471 chr17:61851767 DDX42;CCDC47 0.73 11.17 0.52 9.08e-25 Prudent dietary pattern; CRC cis rs10504229 1.000 rs77120900 chr8:58170368 C/T cg24829409 chr8:58192753 C8orf71 -0.68 -11.34 -0.53 2.27e-25 Developmental language disorder (linguistic errors); CRC cis rs2882667 0.690 rs906695 chr5:138139277 A/G cg09476006 chr5:138032270 NA 0.5 8.63 0.43 2.67e-16 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs9527 0.615 rs10883804 chr10:104706520 G/A cg15744005 chr10:104629667 AS3MT -0.31 -6.17 -0.32 1.96e-9 Arsenic metabolism; CRC cis rs6840360 0.642 rs7657747 chr4:152394254 A/G cg09659197 chr4:152720779 NA 0.34 6.64 0.34 1.27e-10 Intelligence (multi-trait analysis); CRC cis rs12824058 0.831 rs4759657 chr12:130815818 G/A cg26677194 chr12:130822605 PIWIL1 0.45 7.42 0.38 9.93e-13 Menopause (age at onset); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg16437679 chr6:146056419 EPM2A 0.4 6.32 0.33 8.46e-10 Liver disease severity in Alagille syndrome; CRC cis rs10484885 0.824 rs72919954 chr6:90515665 T/A cg13799429 chr6:90582589 CASP8AP2 -0.71 -7.59 -0.39 3.23e-13 QRS interval (sulfonylurea treatment interaction); CRC cis rs5167 0.566 rs5120 chr19:45451620 T/A cg09555818 chr19:45449301 APOC2 0.33 5.7 0.3 2.68e-8 Blood protein levels; CRC cis rs736408 0.609 rs2336545 chr3:52787603 C/T cg18099408 chr3:52552593 STAB1 0.43 7.08 0.36 8.77e-12 Bipolar disorder; CRC cis rs240764 0.604 rs1336242 chr6:101199634 C/T cg09795085 chr6:101329169 ASCC3 0.41 5.64 0.3 3.57e-8 Neuroticism; CRC cis rs4481887 1.000 rs10888351 chr1:248451608 G/A cg00666640 chr1:248458726 OR2T12 0.55 9.78 0.47 5.43e-20 Common traits (Other); CRC cis rs6743226 0.934 rs4303713 chr2:242257859 G/A cg10021735 chr2:242295487 FARP2 0.47 6.85 0.35 3.68e-11 Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI in non-smokers; CRC cis rs4780401 0.703 rs7193637 chr16:11764920 C/T cg01061890 chr16:11836724 TXNDC11 -0.41 -5.66 -0.3 3.37e-8 Rheumatoid arthritis; CRC cis rs4790333 1.000 rs4790332 chr17:2262611 G/A cg02569219 chr17:2266849 SGSM2 0.58 9.86 0.48 2.84e-20 Proinsulin levels; CRC cis rs1568889 1.000 rs12802157 chr11:28060285 A/C cg06544937 chr11:28130018 METT5D1;KIF18A 0.78 11.27 0.53 3.9e-25 Bipolar disorder; CRC cis rs7618915 0.570 rs2336145 chr3:52629750 A/C cg18404041 chr3:52824283 ITIH1 -0.44 -8.98 -0.44 2.17e-17 Bipolar disorder; CRC cis rs7615952 0.641 rs4490307 chr3:125712676 T/G cg04553112 chr3:125709451 NA -0.51 -6.43 -0.33 4.51e-10 Blood pressure (smoking interaction); CRC cis rs9381040 0.610 rs2235679 chr6:41020577 G/T cg09580153 chr6:41068724 NFYA;LOC221442 -0.42 -6.14 -0.32 2.42e-9 Alzheimer's disease (late onset); CRC trans rs6703335 0.870 rs10803142 chr1:243598234 A/G cg19670317 chr17:8093380 C17orf59 0.45 6.47 0.34 3.65e-10 Schizophrenia;Schizophrenia, schizoaffective disorder or bipolar disorder; CRC cis rs2294693 0.891 rs9369256 chr6:40998344 G/C cg14769373 chr6:40998127 UNC5CL -0.56 -7.41 -0.38 1.05e-12 Gastric cancer;Non-cardia gastric cancer; CRC trans rs4263408 0.934 rs9683743 chr4:39703194 A/C cg11164639 chr15:91192950 NA -0.36 -5.99 -0.31 5.46e-9 Plasma amyloid beta peptide concentrations (ABx-40); CRC cis rs1670533 0.872 rs11727135 chr4:1051803 G/C cg27284194 chr4:1044797 NA 0.51 6.35 0.33 7.31e-10 Recombination rate (females); CRC cis rs4925386 0.840 rs6143035 chr20:60920700 C/T cg24112000 chr20:60950667 NA 0.54 8.91 0.44 3.45e-17 Colorectal cancer;Colorectal cancer (SNP x SNP interaction); CRC cis rs7932354 0.583 rs964551 chr11:46897995 G/T cg19486271 chr11:47235900 DDB2 -0.42 -6.35 -0.33 7.28e-10 Bone mineral density (hip);Bone mineral density; CRC cis rs747650 0.504 rs7128193 chr11:46988983 A/C cg19486271 chr11:47235900 DDB2 -0.43 -6.49 -0.34 3.11e-10 Acne (severe); CRC cis rs7940866 0.838 rs7949071 chr11:130877478 T/C cg12179176 chr11:130786555 SNX19 0.58 8.3 0.42 2.77e-15 Schizophrenia; CRC cis rs2302777 0.507 rs9889711 chr17:38108292 A/T cg26162295 chr17:38119207 GSDMA -0.34 -5.67 -0.3 3.09e-8 Multiple myeloma (hyperdiploidy); CRC cis rs7827545 1.000 rs4909481 chr8:135564555 A/G cg13086574 chr8:135490821 ZFAT -0.36 -6.08 -0.32 3.34e-9 Hypertension (SNP x SNP interaction); CRC cis rs7089973 0.872 rs12773943 chr10:116631184 G/A cg23260525 chr10:116636907 FAM160B1 0.32 6.87 0.35 3.2e-11 Bipolar disorder or attention deficit hyperactivity disorder; CRC cis rs2404602 0.583 rs4381566 chr15:76589262 A/G cg03037974 chr15:76606532 NA 0.83 16.81 0.68 3.39e-46 Blood metabolite levels; CRC cis rs6964587 0.585 rs10266481 chr7:91554338 T/C cg17063962 chr7:91808500 NA -0.6 -9.64 -0.47 1.51e-19 Breast cancer; CRC trans rs2547917 0.652 rs2591748 chr5:58677499 C/T cg23342516 chr9:133538893 PRDM12 -0.32 -6.05 -0.32 3.99e-9 Adverse response to chemotherapy (neutropenia/leucopenia) (gemcitabine); CRC cis rs3820068 0.581 rs59991988 chr1:15950552 T/A cg27534772 chr1:16042836 PLEKHM2 0.55 10.98 0.52 4.27e-24 Systolic blood pressure; CRC cis rs10946940 0.965 rs10946935 chr6:27501345 T/C cg02683197 chr6:28174875 NA -0.53 -7.25 -0.37 2.99e-12 Systemic lupus erythematosus; CRC cis rs7811142 1.000 rs7794485 chr7:100068936 T/C cg00814883 chr7:100076585 TSC22D4 -0.82 -10.14 -0.49 3.31e-21 Platelet count; CRC cis rs11105298 0.891 rs11105310 chr12:89918677 C/A cg08166232 chr12:89918718 WDR51B;GALNT4 -0.63 -7.88 -0.4 4.75e-14 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; CRC cis rs8072100 0.840 rs9895746 chr17:45479099 C/A cg25173405 chr17:45401733 C17orf57 -0.51 -8.17 -0.41 6.87e-15 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs8031584 0.958 rs35256769 chr15:31237776 G/A cg08704250 chr15:31115839 NA -0.42 -7.68 -0.39 1.81e-13 Huntington's disease progression; CRC cis rs6543140 0.964 rs6543143 chr2:103085420 A/C cg04239558 chr2:103089729 SLC9A4 0.37 6.61 0.34 1.51e-10 Blood protein levels; CRC trans rs7267979 1.000 rs4815408 chr20:25346678 C/T cg17903999 chr18:56338584 MALT1 0.41 6.72 0.35 8.15e-11 Liver enzyme levels (alkaline phosphatase); CRC cis rs7937682 0.632 rs11214037 chr11:111773296 C/T cg19812747 chr11:111475976 SIK2 0.43 6.3 0.33 9.57e-10 Primary sclerosing cholangitis; CRC cis rs8177253 0.763 rs8177224 chr3:133474003 C/G cg24879335 chr3:133465180 TF -0.32 -5.8 -0.3 1.54e-8 Iron status biomarkers; CRC cis rs8044995 0.517 rs2863973 chr16:68409435 A/C cg09835421 chr16:68378352 PRMT7 -0.6 -7.16 -0.37 5.31e-12 Schizophrenia; CRC cis rs1670533 0.872 rs6854793 chr4:1055768 T/C cg27284194 chr4:1044797 NA 0.51 6.48 0.34 3.41e-10 Recombination rate (females); CRC cis rs2527866 1.000 rs2527866 chr7:157090296 A/C cg00552600 chr7:157091575 NA -0.36 -5.63 -0.3 3.84e-8 Quantitative traits; CRC cis rs4132509 0.895 rs12138168 chr1:244009113 A/G cg21452805 chr1:244014465 NA 0.58 7.33 0.37 1.85e-12 RR interval (heart rate); CRC cis rs7945705 0.902 rs10743095 chr11:8936984 T/C cg14711859 chr11:8959438 ASCL3 -0.46 -7.45 -0.38 8.45e-13 Hemoglobin concentration; CRC cis rs45509595 0.749 rs401763 chr6:27782528 T/C cg19041857 chr6:27730383 NA -0.72 -6.75 -0.35 6.7e-11 Breast cancer; CRC cis rs4731207 0.596 rs1404898 chr7:124694339 G/T cg23710748 chr7:124431027 NA -0.4 -6.3 -0.33 9.53e-10 Cutaneous malignant melanoma; CRC cis rs72945132 0.882 rs12274436 chr11:70132204 T/C cg00319359 chr11:70116639 PPFIA1 0.61 6.79 0.35 5.14e-11 Coronary artery disease; CRC cis rs7085104 0.700 rs10883785 chr10:104603588 A/G cg15744005 chr10:104629667 AS3MT -0.36 -7.73 -0.39 1.33e-13 Immature fraction of reticulocytes;Schizophrenia; CRC cis rs896854 0.654 rs28591375 chr8:95973637 C/G cg23172400 chr8:95962367 TP53INP1 -0.48 -8.17 -0.41 6.79e-15 Type 2 diabetes; CRC cis rs6496667 1.000 rs7178496 chr15:90896959 C/T cg04176472 chr15:90893244 GABARAPL3 0.52 7.95 0.4 3.04e-14 Rheumatoid arthritis; CRC cis rs9372498 0.505 rs9481789 chr6:118734320 A/C cg01339444 chr6:118972232 C6orf204 0.52 5.87 0.31 1.08e-8 Diastolic blood pressure; CRC cis rs35883536 0.933 rs1409419 chr1:101183396 T/C cg14515779 chr1:101123966 NA -0.35 -6.44 -0.33 4.32e-10 Monocyte count; CRC cis rs9467711 0.722 rs35825164 chr6:26117404 T/C cg08501292 chr6:25962987 TRIM38 0.91 8.23 0.41 4.35e-15 Autism spectrum disorder or schizophrenia; CRC cis rs12048904 0.619 rs10875346 chr1:101328083 T/C cg00063077 chr1:101360652 SLC30A7;EXTL2 0.8 12.15 0.56 2.51e-28 Multiple sclerosis; CRC cis rs4665809 0.590 rs6730310 chr2:26419470 C/G cg22920501 chr2:26401640 FAM59B -0.83 -11.51 -0.54 5.41e-26 Gut microbiome composition (summer); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg19842065 chr12:56660480 COQ10A 0.48 7.09 0.36 8.03e-12 Intelligence (multi-trait analysis); CRC cis rs8077889 0.700 rs28571770 chr17:41904066 A/T cg25876840 chr17:41920477 NA 0.53 7.92 0.4 3.77e-14 Triglycerides; CRC cis rs4713118 0.911 rs9295746 chr6:27730064 T/C cg15845792 chr6:28175446 NA 0.66 7.9 0.4 4.21e-14 Parkinson's disease; CRC trans rs9858542 0.953 rs3811697 chr3:49590770 C/T cg21582582 chr3:182698605 DCUN1D1 -0.54 -6.8 -0.35 5.08e-11 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs6988636 0.792 rs62521803 chr8:124152970 A/C cg27053337 chr8:124217698 FAM83A 0.42 5.67 0.3 3.16e-8 Urinary uromodulin levels; CRC cis rs9311676 0.632 rs62258139 chr3:58406836 C/T cg06643156 chr3:58380774 PXK 0.42 6.38 0.33 5.84e-10 Systemic lupus erythematosus; CRC cis rs9486715 0.867 rs2223238 chr6:96871855 G/A cg06623918 chr6:96969491 KIAA0776 1.02 20.3 0.75 5.5e-60 Headache; CRC cis rs616402 0.564 rs7419116 chr1:10578606 G/A cg17425144 chr1:10567563 PEX14 0.55 13.07 0.58 9.6e-32 Breast size; CRC cis rs9916302 0.904 rs2338798 chr17:37547269 T/C cg15445000 chr17:37608096 MED1 -0.42 -9.13 -0.45 7.24e-18 Glomerular filtration rate (creatinine); CRC cis rs9443645 0.687 rs6915558 chr6:79769056 A/T cg09184832 chr6:79620586 NA -0.51 -9.37 -0.46 1.24e-18 Intelligence (multi-trait analysis); CRC cis rs875971 0.964 rs778708 chr7:65856319 T/C cg18876405 chr7:65276391 NA 0.52 9.04 0.45 1.37e-17 Aortic root size; CRC cis rs6901250 0.851 rs339360 chr6:117160872 G/T cg12892004 chr6:117198278 RFX6 -0.42 -6.59 -0.34 1.78e-10 C-reactive protein levels; CRC cis rs7590720 1.000 rs4674051 chr2:216907512 G/C cg12620499 chr2:216877984 MREG 0.84 13.58 0.6 1.19e-33 Alcohol dependence; CRC cis rs1150668 0.699 rs12214383 chr6:28223731 T/C cg21251018 chr6:28226885 NKAPL -0.62 -11.57 -0.54 3.19e-26 Pubertal anthropometrics; CRC cis rs7666738 0.924 rs62318940 chr4:99064768 C/T cg17366294 chr4:99064904 C4orf37 0.46 7.27 0.37 2.65e-12 Colonoscopy-negative controls vs population controls; CRC cis rs1065852 0.526 rs8138080 chr22:42396371 A/G cg00645731 chr22:42541494 CYP2D7P1 -0.4 -6.73 -0.35 7.77e-11 Response to serotonin reuptake inhibitors in major depressive disorder (plasma drug and metabolite levels); CRC cis rs921968 0.565 rs35594672 chr2:219589280 T/A cg02176678 chr2:219576539 TTLL4 -0.39 -6.3 -0.33 9.48e-10 Mean corpuscular hemoglobin concentration; CRC cis rs6500395 1.000 rs9936467 chr16:48677983 T/C cg04672837 chr16:48644449 N4BP1 0.45 6.67 0.35 1.09e-10 Response to tocilizumab in rheumatoid arthritis; CRC cis rs6088580 0.634 rs13041646 chr20:33082881 T/A cg24642439 chr20:33292090 TP53INP2 0.41 6.62 0.34 1.43e-10 Glomerular filtration rate (creatinine); CRC cis rs6484504 0.625 rs1535741 chr11:31375072 T/C cg14844989 chr11:31128820 NA 0.35 6.3 0.33 9.75e-10 Red blood cell count; CRC cis rs67478160 0.643 rs11624184 chr14:104240998 A/G cg01849466 chr14:104193079 ZFYVE21 -0.48 -8.04 -0.41 1.67e-14 Schizophrenia; CRC cis rs7618915 0.547 rs2268027 chr3:52766606 G/A cg07507251 chr3:52567010 NT5DC2 0.44 6.39 0.33 5.81e-10 Bipolar disorder; CRC cis rs4713118 0.513 rs149989 chr6:27998184 T/A cg21251018 chr6:28226885 NKAPL 0.49 7.69 0.39 1.76e-13 Parkinson's disease; CRC cis rs7927771 0.832 rs4752990 chr11:47410393 G/A cg18512352 chr11:47633146 NA -0.4 -7.57 -0.39 3.84e-13 Subjective well-being; CRC cis rs7632954 0.935 rs6770049 chr3:8522388 C/T cg03495237 chr3:8533978 NA 0.35 6.32 0.33 8.32e-10 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs1552244 1.000 rs7651058 chr3:10066964 C/T cg02579736 chr3:10068473 FANCD2;CIDECP 0.95 12.55 0.57 8.85e-30 Alzheimer's disease; CRC cis rs1215050 0.765 rs181521 chr4:98745728 A/C cg05340658 chr4:99064831 C4orf37 0.47 6.88 0.35 3.09e-11 Waist-to-hip ratio adjusted for body mass index; CRC trans rs6076960 0.652 rs3843045 chr20:6264593 C/T cg21095983 chr6:86352623 SYNCRIP -0.46 -6.74 -0.35 6.9e-11 Smooth-surface caries; CRC cis rs2795502 0.564 rs72777186 chr10:43430464 C/T cg20628663 chr10:43360327 NA 0.55 6.76 0.35 6.28e-11 Blood protein levels; CRC cis rs853679 0.517 rs16893666 chr6:28054707 C/T cg12273811 chr6:28175739 NA -0.71 -9.06 -0.45 1.2e-17 Depression; CRC cis rs11155671 0.530 rs1334510 chr6:150201179 A/G cg13206674 chr6:150067644 NUP43 0.5 7.02 0.36 1.25e-11 Testicular germ cell tumor; CRC cis rs2268241 0.938 rs17878783 chr21:34779185 G/A cg14850771 chr21:34775459 IFNGR2 0.77 9.64 0.47 1.6e-19 Obesity-related traits; CRC cis rs7727544 0.716 rs72793278 chr5:131561372 C/A cg04518342 chr5:131593106 PDLIM4 0.37 6.6 0.34 1.67e-10 Blood metabolite levels; CRC cis rs13108904 0.517 rs13134568 chr4:1334289 G/A cg20092199 chr4:1342459 KIAA1530 0.45 7.32 0.37 1.95e-12 Obesity-related traits; CRC cis rs6089584 0.706 rs6089625 chr20:60620622 T/C cg13770153 chr20:60521292 NA -0.56 -8.33 -0.42 2.28e-15 Body mass index; CRC cis rs4474465 0.850 rs7122676 chr11:78268525 A/G cg27205649 chr11:78285834 NARS2 0.46 5.82 0.31 1.42e-8 Alzheimer's disease (survival time); CRC cis rs2073300 0.609 rs3827085 chr20:23356985 A/T cg12062639 chr20:23401060 NAPB 0.69 6.25 0.33 1.28e-9 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs394563 0.556 rs398159 chr6:149792768 T/C cg07828024 chr6:149772892 ZC3H12D -0.41 -6.7 -0.35 9.3e-11 Dupuytren's disease; CRC cis rs7202877 0.656 rs6564245 chr16:75308899 A/G cg03315344 chr16:75512273 CHST6 -0.49 -5.69 -0.3 2.82e-8 Type 2 diabetes;Type 1 diabetes; CRC cis rs13108904 0.846 rs4974574 chr4:1224811 A/G cg21620606 chr4:1342894 KIAA1530 0.36 6.15 0.32 2.21e-9 Obesity-related traits; CRC cis rs751728 1.000 rs11752297 chr6:33735154 G/C cg25922239 chr6:33757077 LEMD2 0.6 8.76 0.43 1.06e-16 Crohn's disease; CRC cis rs6570726 0.689 rs411785 chr6:145888398 G/A cg23711669 chr6:146136114 FBXO30 0.76 13.2 0.59 3.2e-32 Lobe attachment (rater-scored or self-reported); CRC cis rs7618501 1.000 rs11716575 chr3:49744890 A/G cg24308560 chr3:49941425 MST1R 0.45 7.07 0.36 9.39e-12 Intelligence (multi-trait analysis); CRC cis rs11971779 0.648 rs6467852 chr7:139112591 A/C cg23387468 chr7:139079360 LUC7L2 0.41 7.04 0.36 1.14e-11 Diisocyanate-induced asthma; CRC cis rs11212617 0.967 rs625120 chr11:108095220 A/G cg12106634 chr11:108092400 ATM;NPAT 0.43 6.25 0.33 1.25e-9 Response to metformin in type 2 diabetes (glycemic); CRC cis rs875971 0.723 rs28391294 chr7:65654315 T/C cg12463550 chr7:65579703 CRCP -0.54 -7.69 -0.39 1.73e-13 Aortic root size; CRC cis rs4713118 0.662 rs9380045 chr6:28025279 A/G cg23161317 chr6:28129485 ZNF389 0.44 5.71 0.3 2.49e-8 Parkinson's disease; CRC cis rs12024301 0.557 rs61265590 chr1:183591790 A/G cg11505048 chr1:183622726 RGL1;APOBEC4 0.76 6.93 0.36 2.16e-11 Peripheral arterial disease (traffic-related air pollution interaction); CRC trans rs2898857 0.524 rs2906100 chr17:47372764 C/T cg11430096 chr6:110968061 CDK19 0.54 8.14 0.41 8.21e-15 Cancer; CRC cis rs4964805 0.865 rs67825151 chr12:104205444 C/T cg02344784 chr12:104178138 NT5DC3 0.5 6.95 0.36 2e-11 Attention deficit hyperactivity disorder; CRC cis rs7605827 0.930 rs6735633 chr2:15706096 G/A cg19274914 chr2:15703543 NA 0.39 5.98 0.31 5.9e-9 Educational attainment (years of education); CRC cis rs875971 0.862 rs4718383 chr7:66108409 T/C cg18876405 chr7:65276391 NA -0.53 -8.58 -0.43 3.84e-16 Aortic root size; CRC cis rs6952808 0.501 rs4721429 chr7:2171704 T/C cg02951883 chr7:2050386 MAD1L1 -0.6 -9.16 -0.45 5.56e-18 Bipolar disorder and schizophrenia; CRC cis rs6764363 0.506 rs13091018 chr3:277659 A/G cg02057681 chr3:285234 CHL1 0.36 5.9 0.31 9.25e-9 Sudden cardiac arrest; CRC cis rs2721195 0.654 rs4610795 chr8:145881333 C/T cg12270520 chr8:146023939 ZNF517 -0.42 -6.77 -0.35 5.79e-11 Age at first birth; CRC cis rs4713118 0.955 rs9393848 chr6:27688369 C/T cg06470822 chr6:28175283 NA 0.69 9.39 0.46 1.04e-18 Parkinson's disease; CRC cis rs9682041 0.932 rs1525362 chr3:170070702 C/T cg11886554 chr3:170076028 SKIL 0.72 7.76 0.39 1.08e-13 Glomerular filtration rate in non diabetics (creatinine);Glomerular filtration rate (creatinine); CRC cis rs10504229 0.679 rs4738574 chr8:58033771 T/C cg02725872 chr8:58115012 NA -0.36 -6.18 -0.32 1.91e-9 Developmental language disorder (linguistic errors); CRC cis rs11864453 0.612 rs12924413 chr16:72129745 T/C cg23815491 chr16:72088622 HP 0.49 7.51 0.38 5.77e-13 Fibrinogen levels; CRC cis rs9443645 0.901 rs4415132 chr6:79554107 T/C cg09184832 chr6:79620586 NA -0.51 -9.72 -0.47 8.19e-20 Intelligence (multi-trait analysis); CRC cis rs514406 0.505 rs440871 chr1:53173052 C/T cg08859206 chr1:53392774 SCP2 -0.39 -6.03 -0.32 4.46e-9 Monocyte count; CRC cis rs10911251 0.546 rs2027081 chr1:183074576 A/G ch.1.3577855R chr1:183094577 LAMC1 0.86 15.25 0.64 4.14e-40 Colorectal cancer; CRC cis rs66573146 0.831 rs67315413 chr4:6987910 T/C cg00086871 chr4:6988644 TBC1D14 1.03 8.74 0.43 1.19e-16 Granulocyte percentage of myeloid white cells; CRC cis rs12928939 0.723 rs28501298 chr16:71855133 C/G cg03805757 chr16:71968109 PKD1L3 -0.53 -7.07 -0.36 9.19e-12 Post bronchodilator FEV1; CRC cis rs6951245 1.000 rs2363286 chr7:1091625 A/G cg24642844 chr7:1081250 C7orf50 -0.76 -9.58 -0.47 2.4e-19 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs1552244 0.816 rs13059144 chr3:10010197 A/C cg18598329 chr3:10140678 FANCD2;C3orf24 -0.82 -10.77 -0.51 2.33e-23 Alzheimer's disease; CRC cis rs2832191 0.935 rs11910316 chr21:30519729 G/A cg08807101 chr21:30365312 RNF160 -0.6 -9.63 -0.47 1.69e-19 Dental caries; CRC cis rs6952808 0.600 rs2895202 chr7:2131829 T/C cg02951883 chr7:2050386 MAD1L1 -0.69 -10.6 -0.5 8.76e-23 Bipolar disorder and schizophrenia; CRC cis rs72717009 0.825 rs9427399 chr1:161476533 T/C cg15358701 chr1:161410459 NA -0.65 -6.94 -0.36 2.1e-11 Rheumatoid arthritis; CRC cis rs4910157 1 rs4910157 chr11:8941215 A/G cg21881798 chr11:8931708 C11orf17;ST5 0.69 11.21 0.53 6.51e-25 Tonsillectomy; CRC cis rs501120 1.000 rs493874 chr10:44764077 C/T cg09554077 chr10:44749378 NA 0.78 11.96 0.55 1.33e-27 Coronary artery disease;Coronary heart disease; CRC cis rs9467773 1.000 rs9467779 chr6:26536687 A/T cg09904177 chr6:26538194 HMGN4 -0.87 -15.33 -0.65 2.2e-40 Intelligence (multi-trait analysis); CRC cis rs79839061 0.610 rs11733713 chr4:869169 A/G cg14530993 chr4:882597 GAK 0.82 7.83 0.4 6.7e-14 Intelligence (multi-trait analysis); CRC cis rs8180040 0.654 rs62246451 chr3:47211632 C/T cg27129171 chr3:47204927 SETD2 -0.72 -11.38 -0.53 1.64e-25 Colorectal cancer; CRC cis rs1552244 1.000 rs17032295 chr3:10086680 C/T cg18598329 chr3:10140678 FANCD2;C3orf24 -0.82 -11.3 -0.53 3.02e-25 Alzheimer's disease; CRC cis rs875971 0.798 rs12698522 chr7:65967341 T/C cg00343986 chr7:65444356 GUSB 0.45 6.28 0.33 1.08e-9 Aortic root size; CRC cis rs11030122 0.702 rs10500590 chr11:3964724 T/C cg18678763 chr11:4115507 RRM1 -0.51 -8.35 -0.42 1.95e-15 Mean platelet volume;Platelet distribution width; CRC cis rs644799 1.000 rs563653 chr11:95561488 T/G cg03916912 chr11:95522834 CEP57;FAM76B 0.95 18.38 0.71 2.03e-52 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC trans rs2243480 1.000 rs1723267 chr7:65473314 G/A cg10756647 chr7:56101905 PSPH 0.74 8.12 0.41 9.34e-15 Diabetic kidney disease; CRC cis rs9381040 0.610 rs6919961 chr6:41020361 T/A cg04346459 chr6:41068666 NFYA;LOC221442 -0.42 -6.29 -0.33 9.98e-10 Alzheimer's disease (late onset); CRC cis rs4713118 0.911 rs9461406 chr6:27719764 C/T cg03623178 chr6:28175578 NA -0.66 -8.03 -0.4 1.74e-14 Parkinson's disease; CRC cis rs12497850 0.644 rs11928552 chr3:48739883 T/C cg20833759 chr3:49053208 WDR6;DALRD3 0.43 7.18 0.37 4.69e-12 Parkinson's disease; CRC trans rs10982213 0.830 rs2274163 chr9:117188714 C/T cg06753227 chr18:9475508 RALBP1 0.41 6.26 0.33 1.22e-9 Interleukin-6 levels; CRC cis rs1577917 0.682 rs6935918 chr6:86283575 G/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A 0.56 7.76 0.39 1.11e-13 Response to antipsychotic treatment; CRC cis rs7809950 1.000 rs10243340 chr7:107090955 A/G cg23024343 chr7:107201750 COG5 -0.61 -8.89 -0.44 4.18e-17 Coronary artery disease; CRC cis rs2739330 0.731 rs4822450 chr22:24242887 C/T cg23131131 chr22:24373011 LOC391322 -0.63 -9.7 -0.47 1.01e-19 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs796364 1.000 rs10178177 chr2:200829993 G/A cg12253985 chr2:200820533 C2orf60;C2orf47 0.59 6.5 0.34 3.06e-10 Schizophrenia; CRC cis rs9560113 0.959 rs9560108 chr13:112180303 A/C cg10483660 chr13:112241077 NA 0.36 5.81 0.3 1.49e-8 Menarche (age at onset); CRC cis rs9534288 0.843 rs2094245 chr13:46602207 T/C cg15192986 chr13:46630673 CPB2 -0.67 -9.79 -0.48 4.89e-20 Blood protein levels; CRC trans rs7937682 0.889 rs1789359 chr11:111475995 T/A cg18187862 chr3:45730750 SACM1L 0.45 6.55 0.34 2.23e-10 Primary sclerosing cholangitis; CRC cis rs10504229 1.000 rs73607871 chr8:58173007 T/C cg05313129 chr8:58192883 C8orf71 -0.47 -6.99 -0.36 1.49e-11 Developmental language disorder (linguistic errors); CRC cis rs11098499 0.604 rs2389886 chr4:120570422 C/T cg24375607 chr4:120327624 NA 0.51 7.64 0.39 2.39e-13 Corneal astigmatism; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg09112790 chr10:127408004 C10orf137 0.46 6.4 0.33 5.47e-10 Response to antipsychotic treatment; CRC cis rs6582630 0.519 rs11495376 chr12:38284957 A/C cg13010199 chr12:38710504 ALG10B 0.46 6.25 0.33 1.25e-9 Drug-induced liver injury (flucloxacillin); CRC cis rs17023223 0.537 rs4590715 chr1:119750201 C/T cg05756136 chr1:119680316 WARS2 -0.49 -6.73 -0.35 7.51e-11 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for BMI in active individuals; CRC cis rs7246657 0.943 rs10407084 chr19:37907792 T/C cg23950597 chr19:37808831 NA -0.54 -6.51 -0.34 2.82e-10 Coronary artery calcification; CRC cis rs1552244 1.000 rs111392584 chr3:10075991 A/G cg18598329 chr3:10140678 FANCD2;C3orf24 -0.89 -11.87 -0.55 2.69e-27 Alzheimer's disease; CRC cis rs1552244 1.000 rs6442150 chr3:10122575 T/C cg18598329 chr3:10140678 FANCD2;C3orf24 -0.87 -11.82 -0.55 4.24e-27 Alzheimer's disease; CRC cis rs9463078 0.774 rs6935398 chr6:45262427 G/A cg25276700 chr6:44698697 NA -0.28 -6.71 -0.35 8.5e-11 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; CRC cis rs863345 0.604 rs2873593 chr1:158504711 T/C cg12129480 chr1:158549410 OR10X1 -0.3 -6.27 -0.33 1.12e-9 Pneumococcal bacteremia; CRC cis rs17401966 0.931 rs1555849 chr1:10400602 G/T cg19773385 chr1:10388646 KIF1B 0.69 11.42 0.53 1.19e-25 Hepatocellular carcinoma; CRC cis rs832540 0.898 rs170732 chr5:56251777 C/T cg20203395 chr5:56204925 C5orf35 -0.39 -5.78 -0.3 1.72e-8 Coronary artery disease; CRC cis rs4780401 0.728 rs8191335 chr16:11771353 C/A cg01061890 chr16:11836724 TXNDC11 -0.42 -5.82 -0.31 1.39e-8 Rheumatoid arthritis; CRC cis rs9517313 0.591 rs9554480 chr13:99221138 T/A cg20487152 chr13:99095054 FARP1 -0.43 -6.28 -0.33 1.09e-9 Neuroticism; CRC cis rs6951245 0.554 rs58210047 chr7:1149381 G/A cg21664854 chr7:1097933 C7orf50;GPR146 0.59 7.3 0.37 2.21e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs7149337 0.805 rs3007069 chr14:51597392 G/A cg23942311 chr14:51606299 NA 0.84 17.26 0.69 5.3e-48 Cancer; CRC cis rs13108904 0.935 rs2293633 chr4:1291640 T/C cg16405210 chr4:1374714 KIAA1530 -0.44 -6.46 -0.34 3.8e-10 Obesity-related traits; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg16418735 chr3:97483530 ARL6 0.55 7.2 0.37 4.14e-12 Thyroid stimulating hormone; CRC cis rs10493773 0.566 rs11161659 chr1:86183967 T/C cg23216685 chr1:86174607 ZNHIT6 -0.29 -6.73 -0.35 7.78e-11 Urate levels in overweight individuals; CRC trans rs2303319 0.504 rs62189052 chr2:162623869 C/G cg23919916 chr10:103825097 HPS6 -0.69 -5.99 -0.31 5.54e-9 Cognitive function; CRC cis rs763121 0.853 rs6001184 chr22:39052116 C/T cg06544989 chr22:39130855 UNC84B 0.45 6.86 0.35 3.39e-11 Menopause (age at onset); CRC cis rs10752881 1.000 rs8179262 chr1:182973186 C/T ch.1.3577855R chr1:183094577 LAMC1 0.87 15.28 0.64 3.23e-40 Colorectal cancer; CRC cis rs8073060 0.521 rs225254 chr17:33953384 G/A cg05299278 chr17:33885742 SLFN14 0.4 5.99 0.31 5.59e-9 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; CRC cis rs8177253 0.665 rs6774822 chr3:133442012 G/T cg11941060 chr3:133502564 NA -0.44 -7.21 -0.37 3.89e-12 Iron status biomarkers; CRC cis rs7584330 0.740 rs10184904 chr2:238428186 G/C cg14458575 chr2:238380390 NA 0.45 7.75 0.39 1.13e-13 Prostate cancer; CRC cis rs9611565 0.546 rs739129 chr22:42118249 G/A cg03806693 chr22:41940476 POLR3H 1.06 13.33 0.59 1.06e-32 Vitiligo; CRC cis rs155076 1.000 rs261406 chr13:21855854 G/A cg21970626 chr13:21893289 NA 0.44 5.8 0.3 1.59e-8 White matter hyperintensity burden; CRC cis rs6951245 0.882 rs10256720 chr7:1210825 C/G cg20603222 chr7:1096387 C7orf50;GPR146 -0.67 -8.17 -0.41 6.49e-15 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs6062302 0.522 rs3810492 chr20:62219740 G/A cg09650180 chr20:62225654 GMEB2 -0.51 -6.8 -0.35 4.98e-11 Glioblastoma; CRC cis rs6502050 0.835 rs8071737 chr17:80117537 T/C cg22110888 chr17:80059540 CCDC57 0.4 6.48 0.34 3.37e-10 Life satisfaction; CRC trans rs3733585 0.699 rs62294332 chr4:9959989 T/C cg26043149 chr18:55253948 FECH -0.5 -7.62 -0.39 2.81e-13 Cleft plate (environmental tobacco smoke interaction); CRC cis rs35306767 0.716 rs34487581 chr10:897201 G/A cg26597838 chr10:835615 NA 1.23 14.67 0.63 7.55e-38 Eosinophil percentage of granulocytes; CRC trans rs7615952 0.932 rs7629977 chr3:125649573 T/G cg21747405 chr11:67723411 NA -0.43 -6.13 -0.32 2.45e-9 Blood pressure (smoking interaction); CRC cis rs727505 1.000 rs55964341 chr7:124517280 A/G cg23710748 chr7:124431027 NA -0.8 -14.18 -0.62 6.24e-36 Lewy body disease; CRC cis rs6973256 0.661 rs2550989 chr7:133500313 A/T cg03336402 chr7:133662267 EXOC4 -0.55 -7.1 -0.36 7.96e-12 Intelligence (multi-trait analysis); CRC cis rs4853012 0.539 rs9789534 chr2:74362990 A/T cg20891558 chr2:74357851 NA 0.47 7.48 0.38 6.76e-13 Gestational age at birth (maternal effect); CRC cis rs4523957 0.928 rs7406247 chr17:2157925 G/A cg16513277 chr17:2031491 SMG6 0.52 8.67 0.43 2.02e-16 Autism spectrum disorder or schizophrenia;Schizophrenia; CRC cis rs3768617 0.510 rs2296293 chr1:183095477 G/A ch.1.3577855R chr1:183094577 LAMC1 0.89 15.86 0.66 1.84e-42 Fuchs's corneal dystrophy; CRC cis rs10751667 0.666 rs7394427 chr11:970405 G/A cg06064525 chr11:970664 AP2A2 -0.3 -6.11 -0.32 2.78e-9 Alzheimer's disease (late onset); CRC trans rs877282 0.891 rs11253355 chr10:768367 C/G cg22713356 chr15:30763199 NA 1.33 16.07 0.66 2.6e-43 Uric acid levels; CRC cis rs12762955 0.561 rs6560863 chr10:1013535 C/A cg20503657 chr10:835505 NA -0.44 -6.09 -0.32 3.19e-9 Response to angiotensin II receptor blocker therapy; CRC cis rs2645694 0.626 rs2703143 chr4:77830441 A/G cg10057126 chr4:77819792 ANKRD56 0.34 5.7 0.3 2.64e-8 Emphysema distribution in smoking; CRC cis rs10256972 0.732 rs1574108 chr7:1105805 T/C cg18402987 chr7:1209562 NA 0.44 6.48 0.34 3.28e-10 Longevity;Endometriosis; CRC cis rs1712517 1.000 rs1163084 chr10:105039048 T/C cg05636881 chr10:105038444 INA 0.47 8.22 0.41 4.8e-15 Migraine; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg02057063 chr1:114354442 RSBN1 0.39 6.68 0.35 1.01e-10 Liver disease severity in Alagille syndrome; CRC trans rs1455244 0.700 rs7229302 chr18:11508904 G/T cg05935360 chr19:11639865 ECSIT 0.4 6.3 0.33 9.44e-10 Schizophrenia; CRC cis rs12545109 0.800 rs1968551 chr8:57407760 T/C cg09654669 chr8:57350985 NA -0.41 -5.71 -0.3 2.54e-8 Obesity-related traits; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg22358856 chr18:12991346 CEP192 0.44 5.98 0.31 5.92e-9 Anxiety disorder; CRC cis rs13108904 0.557 rs1680030 chr4:1245500 A/T cg15763984 chr4:1342303 KIAA1530 -0.39 -6.07 -0.32 3.52e-9 Obesity-related traits; CRC cis rs875971 1.000 rs778696 chr7:65870813 C/G cg11764359 chr7:65958608 NA 0.61 9.95 0.48 1.41e-20 Aortic root size; CRC cis rs1519814 0.740 rs7845541 chr8:121044393 G/C cg22335954 chr8:121166405 COL14A1 -0.53 -6.0 -0.31 5.17e-9 Breast cancer; CRC trans rs916888 0.610 rs199436 chr17:44789285 C/T cg22433210 chr17:43662623 NA -0.63 -7.68 -0.39 1.86e-13 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs6860806 0.661 rs6871350 chr5:131580220 A/G cg09877947 chr5:131593287 PDLIM4 0.45 8.36 0.42 1.85e-15 Breast cancer; CRC cis rs3008870 0.755 rs2815381 chr1:67514591 G/A cg08660285 chr1:67390436 MIER1;WDR78 0.64 9.03 0.45 1.49e-17 Lymphocyte percentage of white cells; CRC cis rs4665809 0.590 rs35615763 chr2:26468778 C/G cg27170947 chr2:26402098 FAM59B 0.59 7.71 0.39 1.53e-13 Gut microbiome composition (summer); CRC cis rs7123876 0.553 rs12099027 chr11:72433920 A/G cg04827223 chr11:72435913 ARAP1 -0.42 -6.35 -0.33 7.25e-10 Body mass index; CRC cis rs4363385 0.782 rs2152993 chr1:152991695 C/A cg25856811 chr1:152973957 SPRR3 -0.24 -6.71 -0.35 8.61e-11 Inflammatory skin disease; CRC cis rs1552244 0.882 rs13066757 chr3:10045030 C/A cg00166722 chr3:10149974 C3orf24 0.63 8.33 0.42 2.21e-15 Alzheimer's disease; CRC cis rs11608355 0.545 rs11612500 chr12:109897136 T/C cg05360138 chr12:110035743 NA 0.77 8.7 0.43 1.65e-16 Neuroticism; CRC cis rs2739330 0.753 rs4822452 chr22:24254363 C/T cg16132339 chr22:24313637 DDTL;DDT 0.63 10.3 0.49 9.19e-22 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs9467711 0.606 rs9358939 chr6:26416787 C/G cg08501292 chr6:25962987 TRIM38 0.79 6.17 0.32 2e-9 Autism spectrum disorder or schizophrenia; CRC cis rs13191362 1.000 rs66529337 chr6:163005662 G/A cg21926612 chr6:163149169 PACRG;PARK2 0.76 11.15 0.52 1.03e-24 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs6502050 0.835 rs67106357 chr17:80116826 T/G cg19223190 chr17:80058835 NA 0.39 6.25 0.33 1.27e-9 Life satisfaction; CRC cis rs9303401 0.527 rs2116450 chr17:56745561 C/T cg02118635 chr17:56770003 RAD51C;TEX14 0.75 9.02 0.45 1.56e-17 Cognitive test performance; CRC cis rs7412746 0.658 rs4970987 chr1:150949682 T/C cg18016565 chr1:150552671 MCL1 0.44 6.07 0.32 3.53e-9 Melanoma; CRC cis rs10832963 0.924 rs10500834 chr11:18638712 A/T cg20219074 chr11:18656078 SPTY2D1 0.61 8.68 0.43 1.84e-16 Breast cancer; CRC cis rs7772486 0.754 rs702306 chr6:145991029 T/C cg23711669 chr6:146136114 FBXO30 -0.75 -12.71 -0.57 2.21e-30 Lobe attachment (rater-scored or self-reported); CRC cis rs4481887 1.000 rs10888352 chr1:248451965 G/A cg13385794 chr1:248469461 NA 0.38 6.55 0.34 2.23e-10 Common traits (Other); CRC cis rs951366 0.789 rs823097 chr1:205681370 G/A cg23034840 chr1:205782522 SLC41A1 0.47 6.28 0.33 1.08e-9 Menarche (age at onset); CRC cis rs4243830 0.737 rs4908926 chr1:6617041 C/T cg05709478 chr1:6581295 PLEKHG5 -0.56 -6.63 -0.34 1.39e-10 Body mass index; CRC cis rs9291683 0.668 rs2241474 chr4:10086015 T/C cg00071950 chr4:10020882 SLC2A9 0.58 10.2 0.49 2.08e-21 Bone mineral density; CRC cis rs231513 0.911 rs124721 chr17:41959808 T/C cg26893861 chr17:41843967 DUSP3 -0.72 -6.5 -0.34 3.05e-10 Cognitive function; CRC cis rs10752881 0.839 rs2093983 chr1:183094210 T/C ch.1.3577855R chr1:183094577 LAMC1 0.89 15.86 0.66 1.84e-42 Colorectal cancer; CRC cis rs12220238 0.915 rs1908334 chr10:75991721 C/T cg19889307 chr10:75911429 ADK;AP3M1 0.56 5.77 0.3 1.84e-8 Soluble interleukin-2 receptor subunit alpha; CRC cis rs2739330 0.828 rs2330635 chr22:24251344 T/C cg11905131 chr22:24372483 LOC391322 -0.75 -11.85 -0.55 3.26e-27 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs2279817 1.000 rs10788680 chr1:18019454 A/G cg21791023 chr1:18019539 ARHGEF10L 0.49 5.98 0.31 5.67e-9 Neuroticism; CRC cis rs929354 1.000 rs1182378 chr7:157048322 T/C cg05182265 chr7:156933206 UBE3C 0.72 13.66 0.6 5.96e-34 Body mass index; CRC cis rs6088580 0.524 rs2889855 chr20:33276853 A/G cg08999081 chr20:33150536 PIGU -0.34 -5.61 -0.3 4.35e-8 Glomerular filtration rate (creatinine); CRC cis rs1865760 0.713 rs7766342 chr6:25990674 C/A cg17691542 chr6:26056736 HIST1H1C 0.56 8.79 0.44 8.4e-17 Height; CRC cis rs10046574 0.764 rs28422979 chr7:135145924 C/T cg27474649 chr7:135195673 CNOT4 0.71 5.82 0.31 1.39e-8 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs10911232 0.507 rs7515822 chr1:183037803 A/G ch.1.3577855R chr1:183094577 LAMC1 0.82 13.91 0.61 6.75e-35 Hypertriglyceridemia; CRC cis rs10504229 0.775 rs72650869 chr8:58157923 T/A cg05313129 chr8:58192883 C8orf71 -0.48 -6.25 -0.33 1.29e-9 Developmental language disorder (linguistic errors); CRC cis rs3806843 1.000 rs6891995 chr5:140172008 A/G cg16607685 chr5:140181889 PCDHA2;PCDHA1;PCDHA3 -0.26 -5.97 -0.31 6.06e-9 Depressive symptoms (multi-trait analysis); CRC cis rs1005224 0.889 rs9323617 chr14:76158638 A/G cg25116370 chr14:76127843 TTLL5;C14orf1 -0.48 -7.41 -0.38 1.1e-12 Large artery stroke; CRC cis rs68170813 0.523 rs11766131 chr7:107071138 T/C cg02696742 chr7:106810147 HBP1 -0.58 -6.04 -0.32 4.16e-9 Coronary artery disease; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg12830839 chr6:170615752 FAM120B 0.45 6.0 0.31 5.32e-9 Anxiety disorder; CRC trans rs57221529 0.713 rs12522724 chr5:590742 T/C cg25482853 chr8:67687455 SGK3 1.19 14.38 0.62 1e-36 Lung disease severity in cystic fibrosis; CRC cis rs6964587 1.000 rs11981461 chr7:91692662 A/G cg17063962 chr7:91808500 NA 0.8 14.1 0.61 1.25e-35 Breast cancer; CRC cis rs2227564 0.620 rs12783161 chr10:75572201 G/C cg16540259 chr10:75572220 NDST2 0.51 7.85 0.4 5.87e-14 Crohn's disease;Inflammatory bowel disease; CRC cis rs853679 0.546 rs200989 chr6:27816442 A/G cg15845792 chr6:28175446 NA 0.72 6.14 0.32 2.36e-9 Depression; CRC cis rs7618915 0.532 rs13060675 chr3:52674300 T/G cg10802521 chr3:52805072 NEK4 -0.58 -9.0 -0.44 1.8e-17 Bipolar disorder; CRC trans rs208520 0.909 rs9354410 chr6:67018584 C/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.81 9.81 0.48 4.36e-20 Exhaled nitric oxide output; CRC cis rs763121 0.853 rs5757204 chr22:39046700 A/C cg06022373 chr22:39101656 GTPBP1 0.78 12.37 0.56 3.95e-29 Menopause (age at onset); CRC cis rs10946940 0.965 rs6910838 chr6:27515519 A/C cg25164649 chr6:28176230 NA -0.41 -5.68 -0.3 2.93e-8 Systemic lupus erythematosus; CRC cis rs2832191 0.791 rs2832196 chr21:30497412 G/A cg08807101 chr21:30365312 RNF160 -0.62 -9.68 -0.47 1.16e-19 Dental caries; CRC cis rs7224737 1.000 rs7214921 chr17:40294025 T/C cg02228675 chr17:40259724 DHX58 -0.48 -6.8 -0.35 5.05e-11 Fibrinogen levels; CRC cis rs2000999 0.524 rs36125653 chr16:72190805 G/A cg04254540 chr16:71951199 KIAA0174 -0.76 -6.26 -0.33 1.18e-9 Total cholesterol levels;Cholesterol, total;Blood protein levels;LDL cholesterol levels;Haptoglobin levels;LDL cholesterol; CRC cis rs3809566 0.963 rs4775608 chr15:63331940 A/G cg05507819 chr15:63340323 TPM1 0.45 6.85 0.35 3.59e-11 Platelet count; CRC trans rs3942852 0.910 rs10742829 chr11:48115837 C/T cg15704280 chr7:45808275 SEPT13 0.59 7.02 0.36 1.3e-11 Acute lymphoblastic leukemia (childhood); CRC cis rs7772486 0.727 rs4896843 chr6:146063451 T/C cg13319975 chr6:146136371 FBXO30 0.45 6.62 0.34 1.5e-10 Lobe attachment (rater-scored or self-reported); CRC cis rs6582630 0.599 rs1589392 chr12:38418535 G/C cg13010199 chr12:38710504 ALG10B -0.4 -5.7 -0.3 2.63e-8 Drug-induced liver injury (flucloxacillin); CRC cis rs9326248 1.000 rs585849 chr11:117069061 A/G cg11861562 chr11:117069780 TAGLN 0.41 9.3 0.46 1.96e-18 Blood protein levels; CRC cis rs7618915 0.547 rs11709448 chr3:52647449 T/C cg18099408 chr3:52552593 STAB1 -0.44 -7.28 -0.37 2.4e-12 Bipolar disorder; CRC cis rs5769707 0.839 rs73176988 chr22:49989649 G/T cg05373962 chr22:49881684 NA -0.35 -6.77 -0.35 6.05e-11 Monocyte count;Monocyte percentage of white cells; CRC cis rs4253772 0.530 rs6008774 chr22:46755298 C/G cg09491104 chr22:46646882 C22orf40 -0.44 -6.67 -0.35 1.05e-10 LDL cholesterol;Cholesterol, total; CRC cis rs8105895 0.935 rs959908 chr19:22281893 A/C cg02912127 chr19:22235281 ZNF257 -0.41 -5.7 -0.3 2.62e-8 Body mass index (change over time); CRC cis rs11148252 0.553 rs9536236 chr13:53255012 T/A cg02158880 chr13:53174818 NA 0.61 9.39 0.46 1.06e-18 Lewy body disease; CRC cis rs3767633 0.858 rs4300199 chr1:161852057 A/G cg09175582 chr1:161736000 ATF6 0.7 6.29 0.33 1.03e-9 IgG glycosylation; CRC cis rs4713118 0.824 rs2179095 chr6:27750858 A/G cg12273811 chr6:28175739 NA -0.5 -6.63 -0.34 1.42e-10 Parkinson's disease; CRC cis rs62103177 0.810 rs62103178 chr18:77624555 C/G cg12964065 chr18:77638022 KCNG2 0.66 6.74 0.35 7.15e-11 Opioid sensitivity; CRC trans rs7615952 0.546 rs2979340 chr3:125341384 C/T cg07211511 chr3:129823064 LOC729375 -0.62 -7.25 -0.37 3.03e-12 Blood pressure (smoking interaction); CRC cis rs8180040 0.966 rs6787422 chr3:47418509 G/T cg02527881 chr3:46936655 PTH1R -0.39 -7.46 -0.38 7.82e-13 Colorectal cancer; CRC cis rs7618915 0.501 rs6804145 chr3:52694198 C/T cg08222913 chr3:52553049 STAB1 -0.34 -6.26 -0.33 1.22e-9 Bipolar disorder; CRC cis rs7044106 0.734 rs12553070 chr9:123485266 C/T cg09419670 chr9:123605666 PSMD5;LOC253039 0.76 12.39 0.56 3.35e-29 Hip circumference adjusted for BMI; CRC cis rs4727027 0.651 rs12704068 chr7:148856153 T/C cg12479418 chr7:148823350 ZNF425;ZNF398 0.47 6.12 0.32 2.73e-9 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC cis rs2479724 0.870 rs7766960 chr6:41918190 T/G cg17623882 chr6:41773611 USP49 -0.52 -8.32 -0.42 2.32e-15 Menarche (age at onset); CRC cis rs889312 0.500 rs832585 chr5:56125904 T/C cg18230493 chr5:56204884 C5orf35 -0.39 -5.76 -0.3 1.91e-8 Breast cancer;Breast cancer (early onset); CRC cis rs10504229 0.683 rs16921814 chr8:58107421 A/T cg22535103 chr8:58192502 C8orf71 -0.72 -9.06 -0.45 1.19e-17 Developmental language disorder (linguistic errors); CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg16229364 chr3:47866611 DHX30 0.43 5.97 0.31 6.28e-9 Anxiety disorder; CRC cis rs3785574 0.962 rs7215915 chr17:61828385 C/T cg25654072 chr17:61904446 PSMC5;FTSJ3 0.42 5.91 0.31 8.76e-9 Height; CRC cis rs4563143 0.675 rs34113156 chr19:29270822 G/A cg14983838 chr19:29218262 NA 0.48 6.95 0.36 1.93e-11 Methadone dose in opioid dependence; CRC cis rs10911390 0.744 rs116197881 chr1:183652657 C/G cg11505048 chr1:183622726 RGL1;APOBEC4 0.71 6.24 0.33 1.33e-9 Systemic lupus erythematosus; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg16041123 chr14:71373980 PCNX 0.41 6.35 0.33 7.06e-10 Liver disease severity in Alagille syndrome; CRC cis rs7727544 0.606 rs11950562 chr5:131652529 A/C cg02033258 chr5:131593261 PDLIM4 0.3 5.62 0.3 4.07e-8 Blood metabolite levels; CRC cis rs1538970 0.669 rs3219476 chr1:45802670 A/C cg24296786 chr1:45957014 TESK2 0.42 5.92 0.31 8.02e-9 Platelet count; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg26687726 chr19:47220339 PRKD2 0.48 7.11 0.36 7.1e-12 Intelligence (multi-trait analysis); CRC cis rs801193 0.839 rs6968619 chr7:66068867 T/C cg18876405 chr7:65276391 NA -0.6 -10.65 -0.51 5.83e-23 Aortic root size; CRC cis rs6952808 0.635 rs12154473 chr7:1982181 A/G cg04267008 chr7:1944627 MAD1L1 0.54 7.79 0.39 8.7e-14 Bipolar disorder and schizophrenia; CRC cis rs2692947 0.550 rs12623771 chr2:96633504 A/G cg23100626 chr2:96804247 ASTL 0.25 6.92 0.36 2.31e-11 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; CRC cis rs873946 0.586 rs3793686 chr10:134569559 A/G cg18305652 chr10:134549665 INPP5A 0.54 7.47 0.38 7.43e-13 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CRC cis rs896854 0.684 rs2340534 chr8:95992330 G/A cg09323728 chr8:95962352 TP53INP1 -0.43 -7.15 -0.37 5.76e-12 Type 2 diabetes; CRC cis rs1799949 1.000 rs1399323 chr17:41332330 T/C cg25072359 chr17:41440525 NA 0.46 6.94 0.36 2.07e-11 Menopause (age at onset); CRC cis rs9916302 0.706 rs2879259 chr17:37410892 C/G cg15445000 chr17:37608096 MED1 0.32 5.64 0.3 3.58e-8 Glomerular filtration rate (creatinine); CRC trans rs877282 0.945 rs17293517 chr10:778770 C/T cg22713356 chr15:30763199 NA 1.32 16.18 0.67 1.01e-43 Uric acid levels; CRC cis rs34375054 0.687 rs35540170 chr12:125669122 C/G cg06287003 chr12:125626642 AACS -0.57 -7.33 -0.37 1.76e-12 Post bronchodilator FEV1/FVC ratio; CRC cis rs2153535 0.580 rs6597322 chr6:8449952 T/G cg21535247 chr6:8435926 SLC35B3 0.5 7.5 0.38 6.06e-13 Motion sickness; CRC cis rs1728785 1.000 rs11075680 chr16:68565700 G/C cg02972257 chr16:68554789 NA -0.58 -7.08 -0.36 9.03e-12 Ulcerative colitis; CRC cis rs1401999 1.000 rs869417 chr3:183689138 T/C cg01324343 chr3:183735012 ABCC5 0.79 14.28 0.62 2.55e-36 Anterior chamber depth; CRC cis rs1387259 0.723 rs2732488 chr12:48771444 G/A cg04545296 chr12:48745243 ZNF641 0.35 6.07 0.32 3.57e-9 Obstructive sleep apnea trait (apnea hypopnea index); CRC cis rs11645898 0.683 rs72787038 chr16:72066102 A/C cg14768367 chr16:72042858 DHODH -0.56 -6.26 -0.33 1.21e-9 Blood protein levels; CRC trans rs6724465 0.714 rs2089035 chr2:219898076 C/T cg26714650 chr12:56694279 CS -0.56 -6.1 -0.32 2.91e-9 Height; CRC cis rs7178572 0.568 rs3743479 chr15:77406396 A/G cg22256960 chr15:77711686 NA 0.65 9.03 0.45 1.47e-17 Type 2 diabetes; CRC cis rs3806843 0.868 rs2262573 chr5:140123627 T/A cg19875535 chr5:140030758 IK -0.52 -8.31 -0.42 2.56e-15 Depressive symptoms (multi-trait analysis); CRC cis rs6500602 0.673 rs4786512 chr16:4573040 A/G cg06139259 chr16:4526053 HMOX2;NMRAL1 0.44 5.7 0.3 2.7e-8 Schizophrenia; CRC cis rs1862618 0.853 rs866222 chr5:56184444 T/C cg18230493 chr5:56204884 C5orf35 -0.75 -9.27 -0.45 2.61e-18 Initial pursuit acceleration; CRC cis rs8072100 0.967 rs4289035 chr17:45707211 C/T cg08085267 chr17:45401833 C17orf57 -0.59 -9.43 -0.46 7.68e-19 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC trans rs2228479 0.850 rs11649100 chr16:89798179 A/G cg21302420 chr1:112162376 RAP1A 0.72 5.96 0.31 6.55e-9 Skin colour saturation; CRC cis rs853679 0.550 rs6901017 chr6:28152583 T/C cg25164649 chr6:28176230 NA 0.8 10.74 0.51 2.84e-23 Depression; CRC cis rs34375054 0.624 rs12580033 chr12:125676083 A/T cg25124228 chr12:125621409 AACS -0.52 -6.72 -0.35 8.21e-11 Post bronchodilator FEV1/FVC ratio; CRC cis rs2032447 0.802 rs12346 chr6:26097046 T/C cg12588279 chr6:26043732 HIST1H2BB 0.42 5.95 0.31 6.68e-9 Intelligence (multi-trait analysis); CRC cis rs1577917 0.771 rs2475791 chr6:86368164 T/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.7 -9.3 -0.46 1.98e-18 Response to antipsychotic treatment; CRC cis rs10504229 0.683 rs17194792 chr8:58107195 A/C cg08219700 chr8:58056026 NA 0.6 6.83 0.35 4.16e-11 Developmental language disorder (linguistic errors); CRC cis rs654950 0.934 rs662999 chr1:42001160 A/C cg06885757 chr1:42089581 HIVEP3 0.39 6.65 0.34 1.25e-10 Airway imaging phenotypes; CRC cis rs1129187 0.720 rs9471972 chr6:42915021 G/A cg21280719 chr6:42927975 GNMT -0.45 -9.96 -0.48 1.31e-20 Alzheimer's disease in APOE e4+ carriers; CRC cis rs3785574 0.962 rs2584614 chr17:61929445 C/T cg06601766 chr17:61851465 DDX42;CCDC47 0.57 7.96 0.4 2.74e-14 Height; CRC cis rs2411233 1.000 rs1824493 chr15:39284663 A/T cg23129342 chr15:39283510 NA 0.31 5.74 0.3 2.11e-8 Platelet count; CRC cis rs6460942 0.915 rs17444044 chr7:12458736 A/G cg20607287 chr7:12443886 VWDE -0.66 -6.93 -0.36 2.17e-11 Coronary artery disease; CRC cis rs992157 0.643 rs10191283 chr2:219056755 G/A cg00012203 chr2:219082015 ARPC2 0.6 9.86 0.48 2.94e-20 Colorectal cancer; CRC cis rs2204008 0.774 rs7959048 chr12:37948276 T/A cg13010199 chr12:38710504 ALG10B 0.45 5.76 0.3 1.98e-8 Bladder cancer; CRC cis rs4713118 0.786 rs200503 chr6:27785882 A/G cg08798685 chr6:27730294 NA -0.45 -5.89 -0.31 9.48e-9 Parkinson's disease; CRC trans rs2243480 1.000 rs35735127 chr7:65300423 G/T cg10756647 chr7:56101905 PSPH 0.74 7.77 0.39 9.91e-14 Diabetic kidney disease; CRC cis rs1552244 0.882 rs66559400 chr3:10012551 G/A cg00166722 chr3:10149974 C3orf24 0.61 7.96 0.4 2.85e-14 Alzheimer's disease; CRC trans rs9393777 0.841 rs67092078 chr6:27054772 G/A cg06606381 chr12:133084897 FBRSL1 -1.07 -7.34 -0.38 1.71e-12 Intelligence (multi-trait analysis); CRC cis rs6951245 0.529 rs10262070 chr7:1141738 C/T cg24642844 chr7:1081250 C7orf50 -0.49 -6.38 -0.33 5.99e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs3091242 0.933 rs61775167 chr1:25780893 A/G cg20684491 chr1:25596433 NA -0.43 -7.39 -0.38 1.23e-12 Erythrocyte sedimentation rate; CRC cis rs1451375 0.617 rs2876829 chr7:50566762 A/G cg18232548 chr7:50535776 DDC 0.43 5.72 0.3 2.38e-8 Malaria; CRC trans rs35110281 0.782 rs1454651 chr21:45012476 A/G cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.46 7.3 0.37 2.18e-12 Mean corpuscular volume; CRC cis rs883565 0.528 rs4676584 chr3:38965907 C/A cg01426195 chr3:39028469 NA 0.42 7.07 0.36 9.39e-12 Handedness; CRC cis rs868943 0.512 rs10456903 chr6:116541384 A/G cg26893134 chr6:116381904 FRK 0.24 5.68 0.3 2.92e-8 Total cholesterol levels; CRC cis rs6089584 0.566 rs2181589 chr20:60622817 C/T cg13770153 chr20:60521292 NA 0.43 6.91 0.36 2.56e-11 Body mass index; CRC cis rs11252926 0.801 rs12358553 chr10:558014 C/T cg18196295 chr10:418757 DIP2C -0.54 -7.36 -0.38 1.44e-12 Psychosis in Alzheimer's disease; CRC cis rs6860806 0.507 rs2631371 chr5:131703691 G/A cg12564285 chr5:131593104 PDLIM4 -0.46 -7.7 -0.39 1.59e-13 Breast cancer; CRC cis rs801193 1.000 rs2707850 chr7:66203870 G/T cg11764359 chr7:65958608 NA 0.54 8.25 0.41 3.77e-15 Aortic root size; CRC cis rs763014 0.966 rs15564 chr16:677854 G/T cg02475695 chr16:616220 NHLRC4 0.46 7.79 0.39 8.66e-14 Height; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg08555112 chr17:48942811 TOB1 0.56 7.56 0.38 3.93e-13 Thyroid stimulating hormone; CRC cis rs6960043 0.818 rs10264063 chr7:15053193 G/C cg19272540 chr7:15055459 NA 0.24 6.57 0.34 2.02e-10 Type 2 diabetes; CRC cis rs3924048 0.574 rs3923904 chr1:12616535 T/C cg23650765 chr1:12612165 NA 0.36 7.04 0.36 1.13e-11 Optic cup area; CRC cis rs9322193 0.962 rs13215691 chr6:150113802 T/C cg04369109 chr6:150039330 LATS1 -0.44 -6.06 -0.32 3.65e-9 Lung cancer; CRC cis rs1348850 0.558 rs4337505 chr2:178529714 A/T cg02961200 chr2:178257176 LOC100130691;AGPS 0.51 7.11 0.37 7.06e-12 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs3096299 0.606 rs2965960 chr16:89541795 G/A cg05320533 chr16:89541815 ANKRD11 -0.47 -6.53 -0.34 2.54e-10 Multiple myeloma (IgH translocation); CRC cis rs929354 0.713 rs1034785 chr7:157002383 T/C cg16102536 chr7:156981717 UBE3C 0.4 6.73 0.35 7.74e-11 Body mass index; CRC trans rs10983614 1.000 rs7867776 chr9:120072627 A/G cg23438505 chr17:78489298 NA 0.45 6.63 0.34 1.36e-10 Survival in pancreatic cancer; CRC cis rs698833 0.521 rs35627501 chr2:44506971 G/C cg04920474 chr2:44395004 PPM1B 0.4 6.2 0.32 1.66e-9 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; CRC cis rs7493 1.000 rs2158806 chr7:95051998 A/C cg17330251 chr7:94953956 PON1 -0.58 -7.48 -0.38 7.01e-13 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs6570726 0.791 rs400329 chr6:145879442 A/T cg13319975 chr6:146136371 FBXO30 -0.44 -6.52 -0.34 2.66e-10 Lobe attachment (rater-scored or self-reported); CRC cis rs10744422 0.925 rs897391 chr12:123326374 G/A cg25930673 chr12:123319894 HIP1R -0.54 -5.87 -0.31 1.04e-8 Schizophrenia; CRC cis rs9527 0.830 rs11191442 chr10:104643596 T/A cg15744005 chr10:104629667 AS3MT -0.35 -6.5 -0.34 2.89e-10 Arsenic metabolism; CRC cis rs2243480 1.000 rs316327 chr7:65609201 G/T cg12463550 chr7:65579703 CRCP -0.61 -5.72 -0.3 2.41e-8 Diabetic kidney disease; CRC cis rs6500395 0.735 rs2883641 chr16:48664446 T/C cg04672837 chr16:48644449 N4BP1 0.41 5.87 0.31 1.09e-8 Response to tocilizumab in rheumatoid arthritis; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg07080067 chr5:68514103 MRPS36 0.44 6.2 0.32 1.74e-9 Response to antipsychotic treatment; CRC cis rs10450586 0.897 rs6484288 chr11:27317367 T/C cg10370305 chr11:27303972 NA 0.35 5.69 0.3 2.76e-8 Total body bone mineral density; CRC cis rs801193 1.000 rs2659889 chr7:66217112 A/G cg05627663 chr7:65219948 SNORA22;CCT6P1 0.41 6.05 0.32 4.01e-9 Aortic root size; CRC cis rs11098499 0.863 rs6833334 chr4:120504227 C/T cg24375607 chr4:120327624 NA 0.51 7.53 0.38 4.86e-13 Corneal astigmatism; CRC cis rs2404602 1.000 rs6495206 chr15:76870963 C/T cg03037974 chr15:76606532 NA 0.57 9.55 0.47 3.03e-19 Blood metabolite levels; CRC trans rs6557786 0.636 rs17052934 chr8:24840319 A/C cg08497772 chr8:22407100 NA 0.27 6.34 0.33 7.61e-10 Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 2 peripheral neuropathy); CRC cis rs6933660 0.683 rs6916340 chr6:151779064 T/C cg14262678 chr6:151773367 RMND1;C6orf211 0.6 10.21 0.49 1.87e-21 Menarche (age at onset); CRC cis rs12928939 0.517 rs12445641 chr16:71967783 C/T cg03805757 chr16:71968109 PKD1L3 -0.6 -7.97 -0.4 2.63e-14 Post bronchodilator FEV1; CRC cis rs1005277 0.579 rs2023351 chr10:38378814 A/G cg00409905 chr10:38381863 ZNF37A -0.67 -11.2 -0.53 7.11e-25 Extrinsic epigenetic age acceleration; CRC cis rs4713118 0.824 rs9468229 chr6:27750086 G/A cg20933634 chr6:27740509 NA 0.65 9.13 0.45 7.01e-18 Parkinson's disease; CRC cis rs7772486 0.738 rs75288066 chr6:146319386 C/A cg23711669 chr6:146136114 FBXO30 0.68 11.27 0.53 4.04e-25 Lobe attachment (rater-scored or self-reported); CRC cis rs4665809 0.887 rs28699126 chr2:26357294 C/T cg26119090 chr2:26468346 HADHA;HADHB -0.61 -7.97 -0.4 2.66e-14 Gut microbiome composition (summer); CRC cis rs908922 0.676 rs11205032 chr1:152527690 A/G cg09873164 chr1:152488093 CRCT1 0.4 6.74 0.35 7.22e-11 Hair morphology; CRC cis rs806215 1.000 rs806196 chr7:127248414 A/G cg25922125 chr7:127225783 GCC1 0.58 6.37 0.33 6.52e-10 Type 2 diabetes; CRC trans rs1962073 0.623 rs7459532 chr8:10261068 C/T cg06636001 chr8:8085503 FLJ10661 -0.46 -7.18 -0.37 4.78e-12 Response to chemotherapy in breast cancer hypertensive cases (cumulative dose) (bevacizumab); CRC cis rs11190604 0.697 rs12355942 chr10:102201320 T/C cg16342193 chr10:102329863 NA 0.34 5.76 0.3 1.95e-8 Palmitoleic acid (16:1n-7) levels; CRC cis rs9435341 0.965 rs1335055 chr1:107624563 A/G cg11070056 chr1:107600091 PRMT6 0.37 5.76 0.3 1.98e-8 Facial morphology (factor 21, depth of nasal alae); CRC cis rs7937682 0.889 rs12360825 chr11:111528786 A/T cg19812747 chr11:111475976 SIK2 -0.57 -9.7 -0.47 9.82e-20 Primary sclerosing cholangitis; CRC cis rs12477438 0.520 rs11123761 chr2:99705903 A/G cg14399236 chr2:99771627 LIPT1;TSGA10 0.78 13.44 0.6 3.95e-33 Chronic sinus infection; CRC cis rs11098499 0.588 rs2389874 chr4:120554991 A/G cg09307838 chr4:120376055 NA -0.57 -8.94 -0.44 2.94e-17 Corneal astigmatism; CRC cis rs921968 0.678 rs2230115 chr2:219509618 C/A cg02176678 chr2:219576539 TTLL4 0.5 7.98 0.4 2.39e-14 Mean corpuscular hemoglobin concentration; CRC cis rs7833986 0.534 rs17813240 chr8:56925791 C/T cg23139584 chr8:56987506 RPS20;SNORD54 0.82 11.36 0.53 1.87e-25 Height; CRC cis rs1799949 0.930 rs4445938 chr17:41337900 A/C cg25072359 chr17:41440525 NA 0.46 6.97 0.36 1.72e-11 Menopause (age at onset); CRC trans rs6550704 0.687 rs9865314 chr3:22634337 A/G cg27499259 chr13:28400924 NA -0.42 -6.17 -0.32 2e-9 Daytime sleep phenotypes; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg15947099 chr10:70481448 CCAR1 0.38 6.34 0.33 7.43e-10 Liver disease severity in Alagille syndrome; CRC cis rs798554 0.610 rs2248390 chr7:2855594 T/C cg19717773 chr7:2847554 GNA12 -0.47 -8.03 -0.4 1.71e-14 Height; CRC cis rs57994353 0.570 rs10870139 chr9:139303269 G/A cg14119001 chr9:139324193 INPP5E -0.43 -5.6 -0.3 4.44e-8 Eosinophil counts;Cutaneous squamous cell carcinoma; CRC cis rs4648845 0.579 rs4592207 chr1:2369498 A/G cg11214544 chr1:2391121 NA -0.42 -6.59 -0.34 1.76e-10 Schizophrenia; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg10878768 chr1:33430605 RNF19B 0.46 6.9 0.36 2.68e-11 Intelligence (multi-trait analysis); CRC cis rs67311347 1.000 rs28707772 chr3:40504666 G/A cg09455208 chr3:40491958 NA 0.51 9.87 0.48 2.76e-20 Renal cell carcinoma; CRC cis rs13191362 0.507 rs2846536 chr6:163033492 A/G cg21926612 chr6:163149169 PACRG;PARK2 0.59 9.4 0.46 9.34e-19 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs1215050 0.740 rs1084777 chr4:99017542 C/T cg05340658 chr4:99064831 C4orf37 -0.48 -7.3 -0.37 2.19e-12 Waist-to-hip ratio adjusted for body mass index; CRC cis rs34311866 0.808 rs3755958 chr4:963042 C/A cg07828340 chr4:882639 GAK 1.1 10.4 0.5 4.45e-22 Parkinson's disease; CRC cis rs875971 0.862 rs4718319 chr7:65652784 C/A cg11764359 chr7:65958608 NA -0.6 -9.36 -0.46 1.25e-18 Aortic root size; CRC cis rs4731207 0.698 rs4379394 chr7:124519627 C/T cg23710748 chr7:124431027 NA -0.38 -6.08 -0.32 3.42e-9 Cutaneous malignant melanoma; CRC cis rs870825 0.616 rs6852082 chr4:185645783 T/C cg04058563 chr4:185651563 MLF1IP 0.72 9.3 0.46 2.04e-18 Blood protein levels; CRC cis rs888194 0.677 rs7973253 chr12:109878115 A/G cg19025524 chr12:109796872 NA -0.39 -5.64 -0.3 3.65e-8 Neuroticism; CRC trans rs1814175 0.817 rs4881645 chr11:49791168 G/A cg11707556 chr5:10655725 ANKRD33B -0.43 -8.22 -0.41 4.86e-15 Height; CRC cis rs7769051 0.808 rs1467403 chr6:133089952 T/A cg07930552 chr6:133119739 C6orf192 0.58 6.87 0.35 3.15e-11 Type 2 diabetes nephropathy; CRC cis rs4713118 0.824 rs2179095 chr6:27750858 A/G cg02683197 chr6:28174875 NA -0.64 -8.28 -0.42 3.07e-15 Parkinson's disease; CRC cis rs7666738 0.830 rs4699331 chr4:99059816 T/C cg05340658 chr4:99064831 C4orf37 0.6 9.25 0.45 2.97e-18 Colonoscopy-negative controls vs population controls; CRC cis rs4713118 0.662 rs9468278 chr6:28028482 C/T cg12273811 chr6:28175739 NA 0.62 8.22 0.41 4.78e-15 Parkinson's disease; CRC cis rs11098499 0.954 rs12505469 chr4:120249585 C/T cg09307838 chr4:120376055 NA 0.69 10.47 0.5 2.42e-22 Corneal astigmatism; CRC cis rs9322193 0.923 rs10872651 chr6:150089409 A/T cg00933542 chr6:150070202 PCMT1 0.31 6.06 0.32 3.66e-9 Lung cancer; CRC cis rs4843747 0.636 rs11864872 chr16:88105966 A/G cg03395651 chr16:88107091 BANP 0.6 8.16 0.41 7.02e-15 Menopause (age at onset); CRC cis rs9309473 0.607 rs1851546 chr2:73591127 C/A cg20560298 chr2:73613845 ALMS1 -0.49 -6.55 -0.34 2.27e-10 Metabolite levels; CRC cis rs9768139 0.935 rs10155946 chr7:158122116 C/T cg23298862 chr7:158159286 PTPRN2 -0.5 -8.14 -0.41 8.27e-15 Calcium levels; CRC cis rs2477686 0.526 rs1998760 chr1:2397136 C/T cg11214544 chr1:2391121 NA -0.61 -9.5 -0.46 4.63e-19 Non-obstructive azoospermia; CRC cis rs7937682 0.602 rs503905 chr11:111390762 G/C cg09085632 chr11:111637200 PPP2R1B -0.67 -9.9 -0.48 2.18e-20 Primary sclerosing cholangitis; CRC cis rs2949837 0.581 rs2965074 chr7:45983129 G/T cg21268650 chr7:45961089 IGFBP3 0.38 6.46 0.34 3.73e-10 Sitting height ratio; CRC cis rs13256369 1.000 rs10110591 chr8:8576608 G/T cg18904891 chr8:8559673 CLDN23 -0.6 -8.85 -0.44 5.52e-17 Obesity-related traits; CRC cis rs951366 0.559 rs823101 chr1:205667006 T/C cg17178900 chr1:205818956 PM20D1 0.61 8.3 0.42 2.64e-15 Menarche (age at onset); CRC cis rs3751196 1.000 rs12423912 chr12:104176295 G/A cg02344784 chr12:104178138 NT5DC3 0.73 7.73 0.39 1.3e-13 Sense of smell; CRC cis rs4237845 0.761 rs11172378 chr12:58298161 C/T cg00677455 chr12:58241039 CTDSP2 0.65 9.17 0.45 5.42e-18 Intelligence (multi-trait analysis); CRC cis rs7727544 0.507 rs11741341 chr5:131570218 A/G cg24060327 chr5:131705240 SLC22A5 -0.4 -6.2 -0.32 1.72e-9 Blood metabolite levels; CRC cis rs4766646 0.542 rs4766489 chr12:110306345 G/A cg01252219 chr12:110302105 GLTP 0.4 5.84 0.31 1.26e-8 Metabolite levels (MHPG); CRC cis rs2976388 0.609 rs1469811 chr8:143787999 C/T cg24046110 chr8:143859143 LYNX1 0.49 8.54 0.43 4.92e-16 Urinary tract infection frequency; CRC cis rs11628318 0.614 rs1190342 chr14:103100382 C/T cg23461800 chr14:103021989 NA -0.7 -8.05 -0.41 1.57e-14 Platelet count; CRC cis rs4713118 0.513 rs156738 chr6:28014025 G/C cg18032046 chr6:28092343 ZSCAN16 -0.44 -5.94 -0.31 7.37e-9 Parkinson's disease; CRC cis rs4665809 1.000 rs10182857 chr2:26344411 C/T cg26119090 chr2:26468346 HADHA;HADHB -0.61 -7.88 -0.4 4.97e-14 Gut microbiome composition (summer); CRC cis rs11122272 0.735 rs2491408 chr1:231519248 C/G cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.54 -8.09 -0.41 1.18e-14 Hemoglobin concentration; CRC cis rs644799 0.896 rs12146644 chr11:95492878 A/G cg25622487 chr11:95524042 FAM76B;CEP57 0.73 10.85 0.51 1.18e-23 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs6952808 0.689 rs11771625 chr7:2050401 C/T cg22963979 chr7:1858916 MAD1L1 -0.51 -7.35 -0.38 1.54e-12 Bipolar disorder and schizophrenia; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg06312003 chr17:26662584 IFT20;TNFAIP1 0.4 6.05 0.32 3.88e-9 Intelligence (multi-trait analysis); CRC cis rs524281 0.861 rs10791856 chr11:65964650 T/C cg16950941 chr11:66035639 RAB1B -0.58 -7.22 -0.37 3.68e-12 Electroencephalogram traits; CRC cis rs2739330 0.828 rs2154593 chr22:24252085 A/G cg11060661 chr22:24314208 DDT;DDTL 0.5 8.46 0.42 8.64e-16 Liver enzyme levels (gamma-glutamyl transferase); CRC trans rs3960554 0.529 rs6465049 chr7:75874489 A/G cg19862616 chr7:65841803 NCRNA00174 0.46 6.22 0.32 1.49e-9 Eotaxin levels; CRC cis rs854572 1.000 rs854572 chr7:94954696 C/G cg04871131 chr7:94954202 PON1 -0.67 -10.8 -0.51 1.74e-23 Paraoxonase activity; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg21294471 chr11:35639653 FJX1 0.37 6.2 0.32 1.72e-9 Liver disease severity in Alagille syndrome; CRC cis rs3733585 0.673 rs6814664 chr4:9956228 C/T cg00071950 chr4:10020882 SLC2A9 -0.55 -9.75 -0.47 6.56e-20 Cleft plate (environmental tobacco smoke interaction); CRC cis rs4664293 0.647 rs4144512 chr2:160507519 G/A cg08347373 chr2:160653686 CD302 0.39 6.68 0.35 1.03e-10 Monocyte percentage of white cells; CRC cis rs2576037 0.583 rs9954336 chr18:44465945 A/G cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.63 11.09 0.52 1.73e-24 Personality dimensions; CRC cis rs7586673 0.725 rs6757645 chr2:161891382 A/G cg22496339 chr2:162101262 NA 0.48 7.0 0.36 1.43e-11 Intelligence (multi-trait analysis); CRC cis rs1178968 0.901 rs1178953 chr7:72781277 A/G cg25889504 chr7:72793014 NA 0.54 6.05 0.32 4.01e-9 Triglyceride levels; CRC cis rs9467711 0.790 rs34158769 chr6:26336572 G/A cg08501292 chr6:25962987 TRIM38 0.83 5.93 0.31 7.73e-9 Autism spectrum disorder or schizophrenia; CRC cis rs6860806 0.507 rs272878 chr5:131671769 C/T cg04518342 chr5:131593106 PDLIM4 -0.45 -7.54 -0.38 4.47e-13 Breast cancer; CRC cis rs6570726 0.526 rs9376928 chr6:145724403 T/G cg23711669 chr6:146136114 FBXO30 -0.48 -7.82 -0.4 7.05e-14 Lobe attachment (rater-scored or self-reported); CRC cis rs10464366 0.614 rs62442213 chr7:39146933 C/T cg15212455 chr7:39170539 POU6F2 0.5 6.53 0.34 2.53e-10 IgG glycosylation; CRC cis rs9916302 0.904 rs35285898 chr17:37555872 A/C cg03013999 chr17:37608204 MED1 -0.47 -7.31 -0.37 2e-12 Glomerular filtration rate (creatinine); CRC cis rs9905704 0.881 rs302846 chr17:56687536 T/A cg12560992 chr17:57184187 TRIM37 0.57 8.31 0.42 2.59e-15 Testicular germ cell tumor; CRC cis rs7659604 0.537 rs6823818 chr4:122731699 G/C cg23574427 chr4:122746245 BBS7;CCNA2 -0.3 -5.65 -0.3 3.39e-8 Type 2 diabetes; CRC cis rs2243480 1.000 rs781150 chr7:65480973 C/T cg25985355 chr7:65971099 NA -0.52 -5.89 -0.31 9.55e-9 Diabetic kidney disease; CRC cis rs9443645 0.901 rs6937465 chr6:79570345 G/T cg05283184 chr6:79620031 NA -0.56 -9.02 -0.45 1.62e-17 Intelligence (multi-trait analysis); CRC trans rs8097070 0.661 rs9966711 chr18:23171413 C/G cg21950287 chr19:54385441 PRKCG 0.55 6.05 0.32 3.88e-9 Systemic juvenile idiopathic arthritis; CRC cis rs123509 0.687 rs73077220 chr3:42842340 T/C cg12982090 chr3:42733453 KBTBD5 -0.56 -6.82 -0.35 4.36e-11 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs10504229 0.906 rs116341227 chr8:58190532 G/C cg24829409 chr8:58192753 C8orf71 -0.68 -11.29 -0.53 3.23e-25 Developmental language disorder (linguistic errors); CRC cis rs6088580 0.634 rs1205344 chr20:32918298 G/A cg08999081 chr20:33150536 PIGU -0.64 -11.73 -0.54 8.98e-27 Glomerular filtration rate (creatinine); CRC trans rs12541902 0.574 rs4504625 chr8:60641332 A/T cg07441319 chr10:8117467 NA 0.38 6.09 0.32 3.2e-9 Obesity-related traits; CRC cis rs3093024 0.874 rs3093018 chr6:167539805 C/T cg07513332 chr6:167530253 CCR6 -0.4 -7.31 -0.37 2.04e-12 Rheumatoid arthritis; CRC cis rs910316 1.000 rs4322591 chr14:75600697 C/T cg11812906 chr14:75593930 NEK9 0.63 10.06 0.48 6.32e-21 Height; CRC cis rs780096 0.546 rs1260320 chr2:27722416 A/G cg24768116 chr2:27665128 KRTCAP3 0.32 7.17 0.37 5.09e-12 Total body bone mineral density; CRC cis rs4862750 0.914 rs1346126 chr4:187876404 T/C cg22105103 chr4:187893119 NA 0.63 11.47 0.53 7.64e-26 Lobe attachment (rater-scored or self-reported); CRC cis rs6696846 0.777 rs6664397 chr1:205051871 C/T cg00857998 chr1:205179979 DSTYK 0.41 5.77 0.3 1.79e-8 Red blood cell count; CRC cis rs853679 0.505 rs200992 chr6:27814677 A/G cg26587870 chr6:27730563 NA -0.63 -6.05 -0.32 4.04e-9 Depression; CRC cis rs4731207 0.698 rs17147496 chr7:124449868 G/A cg23710748 chr7:124431027 NA 0.37 5.96 0.31 6.53e-9 Cutaneous malignant melanoma; CRC trans rs951252 0.504 rs11734405 chr4:146081096 C/T cg02862674 chr6:44238426 TMEM151B 0.39 6.4 0.33 5.37e-10 Hip circumference; CRC cis rs6032067 0.852 rs17424613 chr20:43806441 C/T cg10761708 chr20:43804764 PI3 0.51 5.89 0.31 9.53e-9 Blood protein levels; CRC cis rs2280630 0.529 rs6599010 chr3:39153222 C/T cg01426195 chr3:39028469 NA -0.42 -7.16 -0.37 5.35e-12 Verbal declarative memory; CRC cis rs514406 0.893 rs476108 chr1:53317351 C/T cg08859206 chr1:53392774 SCP2 -0.44 -6.9 -0.36 2.66e-11 Monocyte count; CRC cis rs6912958 0.559 rs446851 chr6:88043640 G/A cg12350822 chr6:88032061 C6orf162;GJB7 0.49 9.96 0.48 1.38e-20 Monocyte percentage of white cells; CRC cis rs9905704 0.836 rs170024 chr17:56831887 T/C cg12560992 chr17:57184187 TRIM37 0.55 7.92 0.4 3.66e-14 Testicular germ cell tumor; CRC cis rs7178572 0.568 rs12443386 chr15:77491389 C/T cg22256960 chr15:77711686 NA 0.63 8.67 0.43 1.93e-16 Type 2 diabetes; CRC cis rs4589502 1.000 rs7170743 chr15:67126339 T/G cg12317470 chr15:67143691 NA 0.72 5.93 0.31 7.58e-9 Lung cancer (smoking interaction); CRC trans rs944990 0.595 rs10123378 chr9:96375217 C/T cg14824382 chr8:144680115 EEF1D;TIGD5 0.37 5.98 0.31 5.75e-9 Body mass index; CRC cis rs4713118 0.615 rs9295747 chr6:27736993 G/T cg15786705 chr6:28176104 NA -0.49 -6.97 -0.36 1.74e-11 Parkinson's disease; CRC cis rs10979 1.000 rs1416207 chr6:143889275 G/A cg25407410 chr6:143891975 LOC285740 -0.82 -13.4 -0.59 5.5e-33 Hypospadias; CRC cis rs812925 0.519 rs2694627 chr2:61625506 A/G cg10580144 chr2:61372316 C2orf74 -0.33 -7.08 -0.36 8.84e-12 Immature fraction of reticulocytes; CRC cis rs6496044 0.568 rs6496049 chr15:86069205 C/G cg17133734 chr15:86042851 AKAP13 0.39 6.31 0.33 9.23e-10 Interstitial lung disease; CRC cis rs6582630 0.519 rs11609739 chr12:38547969 G/A cg26384229 chr12:38710491 ALG10B 0.72 9.66 0.47 1.31e-19 Drug-induced liver injury (flucloxacillin); CRC cis rs10782582 0.609 rs80059220 chr1:76279112 G/T cg03433033 chr1:76189801 ACADM -0.41 -5.88 -0.31 1.01e-8 Daytime sleep phenotypes; CRC trans rs11098499 0.909 rs6842762 chr4:120398236 A/T cg25214090 chr10:38739885 LOC399744 0.65 10.37 0.5 5.42e-22 Corneal astigmatism; CRC cis rs933688 1.000 rs9293568 chr5:90737845 C/T cg26981201 chr5:90679533 LOC100129716;ARRDC3 0.98 15.01 0.64 3.59e-39 Smoking behavior; CRC cis rs11628318 0.713 rs1998419 chr14:103050397 C/G cg02094049 chr14:103021097 NA -0.53 -6.84 -0.35 3.9e-11 Platelet count; CRC cis rs4713118 0.540 rs469227 chr6:27970705 A/C cg12172441 chr6:28176163 NA 0.54 7.43 0.38 9.55e-13 Parkinson's disease; CRC cis rs10256972 0.552 rs2960837 chr7:1203957 A/G cg03923535 chr7:1197113 ZFAND2A 0.73 11.16 0.52 9.91e-25 Longevity;Endometriosis; CRC cis rs25645 0.502 rs8065126 chr17:38099035 C/T cg17344932 chr17:38183730 MED24;SNORD124 0.6 9.65 0.47 1.42e-19 Myeloid white cell count; CRC cis rs5769765 0.862 rs138856 chr22:50199378 G/T cg04121214 chr22:50244548 NA 0.4 5.71 0.3 2.47e-8 Schizophrenia; CRC cis rs4466137 0.830 rs6886695 chr5:82994293 T/A cg16102102 chr5:83017553 HAPLN1 -0.58 -8.12 -0.41 9.37e-15 Prostate cancer; CRC cis rs9533799 0.966 rs7999368 chr13:44807184 G/A cg19190762 chr13:44806055 NA 0.62 9.49 0.46 4.7e-19 Amyotrophic lateral sclerosis; CRC cis rs10751667 0.666 rs7396509 chr11:956761 G/A cg01483505 chr11:975446 AP2A2 0.46 7.62 0.39 2.78e-13 Alzheimer's disease (late onset); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg20777176 chr1:231376761 GNPAT;C1orf131 0.44 6.09 0.32 3.14e-9 Response to antipsychotic treatment; CRC cis rs6585424 1.000 rs35180576 chr10:81922971 G/A cg11900509 chr10:81946545 ANXA11 -0.76 -9.29 -0.46 2.25e-18 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs2014572 0.967 rs10413037 chr19:57771883 A/G cg24459738 chr19:57751996 ZNF805 -0.57 -9.16 -0.45 5.65e-18 Hyperactive-impulsive symptoms; CRC cis rs2354432 0.607 rs6677679 chr1:146803630 C/T cg25205988 chr1:146714368 CHD1L -1.14 -9.47 -0.46 5.64e-19 Mitochondrial DNA levels; CRC cis rs9322193 0.923 rs9322214 chr6:150025122 C/T cg05861140 chr6:150128134 PCMT1 -0.38 -5.98 -0.31 5.92e-9 Lung cancer; CRC cis rs9487051 0.872 rs9372211 chr6:109609648 C/T cg12927641 chr6:109611667 NA -0.37 -6.73 -0.35 7.39e-11 Reticulocyte fraction of red cells; CRC cis rs12200560 0.505 rs211183 chr6:97074723 G/T cg06623918 chr6:96969491 KIAA0776 -0.49 -7.22 -0.37 3.55e-12 Coronary heart disease; CRC cis rs6582630 0.502 rs11520279 chr12:38360871 A/G cg26384229 chr12:38710491 ALG10B 0.68 9.75 0.47 6.92e-20 Drug-induced liver injury (flucloxacillin); CRC cis rs651907 0.557 rs62284199 chr3:101478531 T/G cg11279151 chr3:101281821 RG9MTD1 -0.55 -7.54 -0.38 4.68e-13 Colorectal cancer; CRC cis rs16975963 0.843 rs73041022 chr19:38272394 C/T cg15135657 chr19:38346511 NA -0.44 -5.89 -0.31 9.55e-9 Longevity; CRC cis rs17767392 0.918 rs17178234 chr14:71900364 A/G cg13720639 chr14:72061746 SIPA1L1 -0.55 -6.95 -0.36 1.96e-11 Mitral valve prolapse; CRC cis rs6963495 0.745 rs73192153 chr7:105212418 A/T cg02135003 chr7:105160482 PUS7 -0.94 -12.5 -0.57 1.37e-29 Bipolar disorder (body mass index interaction); CRC cis rs425277 1.000 rs262654 chr1:2089526 G/A cg24578937 chr1:2090814 PRKCZ 0.66 11.61 0.54 2.35e-26 Height; CRC cis rs7208859 0.614 rs216412 chr17:28903394 A/G cg19761014 chr17:28927070 LRRC37B2 -0.57 -7.37 -0.38 1.4e-12 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs9372498 0.536 rs9489477 chr6:118946192 T/G cg24463073 chr6:118973353 C6orf204 0.48 6.22 0.32 1.49e-9 Diastolic blood pressure; CRC cis rs2179367 0.887 rs2789492 chr6:149747379 A/G cg07828024 chr6:149772892 ZC3H12D 0.35 5.81 0.31 1.45e-8 Dupuytren's disease; CRC cis rs9443645 0.527 rs9361477 chr6:79710806 C/T cg05283184 chr6:79620031 NA -0.45 -6.45 -0.34 4.01e-10 Intelligence (multi-trait analysis); CRC cis rs72634258 0.842 rs4908727 chr1:8163122 C/T cg26816564 chr1:7831052 VAMP3 0.49 5.86 0.31 1.1e-8 Inflammatory bowel disease; CRC cis rs1448094 0.512 rs7133591 chr12:86239752 G/C cg25456477 chr12:86230367 RASSF9 0.32 5.64 0.3 3.58e-8 Major depressive disorder; CRC cis rs4434138 0.664 rs62255364 chr3:52701502 C/T cg07507251 chr3:52567010 NT5DC2 0.41 5.89 0.31 9.77e-9 Intelligence (multi-trait analysis); CRC cis rs34172651 0.517 rs2303083 chr16:24835168 G/A cg00339695 chr16:24857497 SLC5A11 0.37 6.8 0.35 5.05e-11 Intelligence (multi-trait analysis); CRC cis rs2976388 0.609 rs2572904 chr8:143792193 A/C cg22687807 chr8:143858763 LYNX1 0.51 9.17 0.45 5.35e-18 Urinary tract infection frequency; CRC cis rs9916302 0.904 rs10852933 chr17:37698194 G/T cg15445000 chr17:37608096 MED1 0.43 9.43 0.46 7.8e-19 Glomerular filtration rate (creatinine); CRC cis rs990171 1.000 rs6716784 chr2:103048467 T/G cg03938978 chr2:103052716 IL18RAP 0.46 5.9 0.31 9.09e-9 Lymphocyte counts; CRC cis rs6694672 0.850 rs6428387 chr1:197061557 A/G cg13682187 chr1:196946512 CFHR5 0.47 7.57 0.39 3.82e-13 Asthma; CRC cis rs9560113 0.597 rs1163644 chr13:112241223 C/T cg10483660 chr13:112241077 NA -0.64 -12.93 -0.58 3.39e-31 Menarche (age at onset); CRC cis rs1552244 1.000 rs9881859 chr3:10072814 A/T cg00166722 chr3:10149974 C3orf24 0.65 8.74 0.43 1.18e-16 Alzheimer's disease; CRC cis rs995000 0.899 rs6696502 chr1:63039533 C/T cg19896129 chr1:63156450 NA -0.43 -6.7 -0.35 8.85e-11 Triglyceride levels; CRC cis rs8105895 0.935 rs28894669 chr19:22243264 G/A cg02657401 chr19:22469223 NA -0.34 -5.65 -0.3 3.56e-8 Body mass index (change over time); CRC trans rs7618501 0.633 rs6771546 chr3:49968572 T/C cg21659725 chr3:3221576 CRBN 0.54 8.4 0.42 1.37e-15 Intelligence (multi-trait analysis); CRC cis rs11209185 0.509 rs12130147 chr1:68446944 G/A cg22082780 chr1:68452167 NA 0.41 6.17 0.32 2.05e-9 Itch intensity from mosquito bite adjusted by bite size; CRC cis rs6921919 0.583 rs28360638 chr6:28362329 C/T cg21251018 chr6:28226885 NKAPL 0.4 6.06 0.32 3.66e-9 Autism spectrum disorder or schizophrenia; CRC cis rs11690935 0.959 rs3770452 chr2:172668682 A/G cg13550731 chr2:172543902 DYNC1I2 -1.08 -18.54 -0.71 4.67e-53 Schizophrenia; CRC cis rs1707322 0.721 rs12049027 chr1:46118184 A/T cg06784218 chr1:46089804 CCDC17 0.65 12.18 0.56 2.04e-28 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs7258465 1.000 rs8103622 chr19:18572834 C/T cg10790698 chr19:18539756 SSBP4 -0.42 -7.94 -0.4 3.2e-14 Breast cancer; CRC cis rs3733585 0.699 rs6449177 chr4:9968050 T/C cg00071950 chr4:10020882 SLC2A9 -0.55 -9.82 -0.48 3.92e-20 Cleft plate (environmental tobacco smoke interaction); CRC cis rs36715 1.000 rs40527 chr5:127550252 A/C cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.62 7.99 0.4 2.37e-14 Breast cancer; CRC cis rs9303542 0.592 rs34378400 chr17:46589265 A/G cg04904318 chr17:46607828 HOXB1 -0.52 -6.27 -0.33 1.16e-9 Ovarian cancer;Epithelial ovarian cancer; CRC cis rs10504229 0.679 rs12375445 chr8:58040082 A/G cg22535103 chr8:58192502 C8orf71 -0.44 -5.81 -0.3 1.49e-8 Developmental language disorder (linguistic errors); CRC cis rs10504229 0.683 rs61201557 chr8:58138370 T/C cg22535103 chr8:58192502 C8orf71 -0.7 -9.34 -0.46 1.47e-18 Developmental language disorder (linguistic errors); CRC cis rs3096299 0.967 rs2965932 chr16:89477051 C/T cg01788221 chr16:89496183 ANKRD11 0.44 6.66 0.34 1.12e-10 Multiple myeloma (IgH translocation); CRC cis rs17376456 0.877 rs10476597 chr5:93367172 C/T cg09848695 chr5:92956644 FAM172A;MIR2277 -0.63 -5.92 -0.31 8.12e-9 Diabetic retinopathy; CRC cis rs4969178 0.931 rs6501208 chr17:76395038 A/T cg05887092 chr17:76393375 PGS1 0.55 10.17 0.49 2.62e-21 HDL cholesterol levels; CRC cis rs2404602 0.647 rs2404600 chr15:77173557 C/T cg03037974 chr15:76606532 NA -0.53 -7.42 -0.38 9.8e-13 Blood metabolite levels; CRC cis rs9916302 0.851 rs11657899 chr17:37626963 G/A cg15445000 chr17:37608096 MED1 0.43 9.47 0.46 5.76e-19 Glomerular filtration rate (creatinine); CRC trans rs1005277 0.579 rs2023351 chr10:38378814 A/G cg11292332 chr7:45801988 SEPT13 -0.35 -6.21 -0.32 1.62e-9 Extrinsic epigenetic age acceleration; CRC cis rs9399135 0.660 rs4440481 chr6:135276696 A/G cg22676075 chr6:135203613 NA 0.51 7.78 0.39 9.58e-14 Red blood cell count; CRC cis rs933688 1.000 rs985434 chr5:90744509 A/G cg02339078 chr5:90679543 LOC100129716;ARRDC3 0.88 13.58 0.6 1.14e-33 Smoking behavior; CRC cis rs6545883 0.929 rs2264100 chr2:61670829 G/A cg15711740 chr2:61764176 XPO1 -0.45 -5.91 -0.31 8.59e-9 Tuberculosis; CRC cis rs28386778 0.897 rs2727320 chr17:61865325 T/C cg25654072 chr17:61904446 PSMC5;FTSJ3 0.74 11.57 0.54 3.23e-26 Prudent dietary pattern; CRC cis rs7726839 0.540 rs12517638 chr5:645484 C/T cg14541582 chr5:601475 NA -0.33 -6.59 -0.34 1.73e-10 Obesity-related traits; CRC cis rs9902453 0.836 rs62070337 chr17:28466257 G/A cg26525008 chr17:28256777 EFCAB5;SSH2 0.59 9.2 0.45 4.18e-18 Coffee consumption (cups per day); CRC cis rs8105895 0.733 rs62111029 chr19:22276601 C/A cg02912127 chr19:22235281 ZNF257 -0.41 -5.7 -0.3 2.62e-8 Body mass index (change over time); CRC cis rs17666538 0.710 rs7834337 chr8:655828 A/G cg07685180 chr8:600429 NA 0.74 7.9 0.4 4.11e-14 IgG glycosylation; CRC cis rs4737010 0.570 rs6474364 chr8:41646997 T/G cg17182837 chr8:41585554 ANK1 -0.54 -7.56 -0.38 4.02e-13 Lymphocyte counts;High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Reticulocyte count;Reticulocyte fraction of red cells;Mean corpuscular volume;Immature fraction of reticulocytes;Mean corpuscular hemoglobin concentration; CRC cis rs6460942 1.000 rs79659770 chr7:12326371 T/C cg20607287 chr7:12443886 VWDE -0.65 -6.45 -0.34 3.92e-10 Coronary artery disease; CRC cis rs6951245 0.529 rs76001997 chr7:1152615 C/T cg20603222 chr7:1096387 C7orf50;GPR146 -0.43 -5.61 -0.3 4.4e-8 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs12620999 1.000 rs12620999 chr2:238036367 C/T cg23555395 chr2:238036564 NA -0.63 -9.93 -0.48 1.71e-20 Systemic lupus erythematosus; CRC cis rs2415984 0.622 rs1761027 chr14:46929611 G/A cg14871534 chr14:47121158 RPL10L 0.4 5.82 0.31 1.42e-8 Number of children ever born; CRC cis rs875971 0.862 rs7803416 chr7:65954199 A/G cg12463550 chr7:65579703 CRCP 0.47 6.71 0.35 8.61e-11 Aortic root size; CRC cis rs2075371 1.000 rs2598286 chr7:133976029 G/A cg02659138 chr7:134003124 SLC35B4 0.35 6.09 0.32 3.18e-9 Mean platelet volume; CRC cis rs2204008 0.658 rs12371956 chr12:38298010 A/T cg26384229 chr12:38710491 ALG10B 0.69 9.74 0.47 7.18e-20 Bladder cancer; CRC cis rs995000 0.931 rs10159255 chr1:63020816 C/A cg19896129 chr1:63156450 NA 0.4 5.86 0.31 1.11e-8 Triglyceride levels; CRC cis rs6502050 0.736 rs11658040 chr17:80059891 C/T cg19223190 chr17:80058835 NA -0.5 -7.93 -0.4 3.44e-14 Life satisfaction; CRC cis rs11608355 0.515 rs11609921 chr12:109918405 A/G cg05360138 chr12:110035743 NA 0.78 8.76 0.43 1.07e-16 Neuroticism; CRC cis rs1003719 1.000 rs1003719 chr21:38491095 A/G cg10648535 chr21:38446584 PIGP;TTC3 0.53 7.13 0.37 6.51e-12 Eye color traits; CRC cis rs597539 0.652 rs611046 chr11:68631704 A/G cg06028808 chr11:68637592 NA 0.43 6.94 0.36 2.13e-11 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs921968 0.541 rs3770214 chr2:219508988 C/T cg02176678 chr2:219576539 TTLL4 -0.57 -8.88 -0.44 4.52e-17 Mean corpuscular hemoglobin concentration; CRC cis rs1448094 0.842 rs7301280 chr12:86455752 G/T cg02569458 chr12:86230093 RASSF9 -0.41 -7.03 -0.36 1.21e-11 Major depressive disorder; CRC cis rs6088813 0.922 rs4911493 chr20:33960799 A/G cg14752227 chr20:34000481 UQCC -0.37 -5.68 -0.3 2.98e-8 Height; CRC cis rs11148252 0.774 rs9596649 chr13:52934610 A/G cg02158880 chr13:53174818 NA -0.46 -7.02 -0.36 1.26e-11 Lewy body disease; CRC cis rs950776 0.720 rs11633223 chr15:78935476 T/C cg06917634 chr15:78832804 PSMA4 0.49 7.17 0.37 4.83e-12 Sudden cardiac arrest; CRC cis rs832540 0.519 rs10039338 chr5:56260363 C/T cg12311346 chr5:56204834 C5orf35 0.46 7.27 0.37 2.68e-12 Coronary artery disease; CRC cis rs9611565 0.643 rs202634 chr22:41809623 A/G cg03806693 chr22:41940476 POLR3H 1.05 13.01 0.58 1.6e-31 Vitiligo; CRC cis rs1348850 0.874 rs1348848 chr2:178358233 A/C cg22681709 chr2:178499509 PDE11A 0.4 7.5 0.38 5.86e-13 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs4713118 0.739 rs2893931 chr6:27748010 G/A cg25164649 chr6:28176230 NA 0.6 7.91 0.4 3.87e-14 Parkinson's disease; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg04056025 chr13:45694609 GTF2F2 0.45 6.12 0.32 2.7e-9 Anxiety disorder; CRC trans rs62295889 0.602 rs73096514 chr4:12536931 G/A cg03490839 chr16:73082051 ZFHX3 0.58 6.06 0.32 3.82e-9 Obesity-related traits; CRC cis rs9768139 0.935 rs6953748 chr7:158121184 G/A cg25566285 chr7:158114605 PTPRN2 -0.58 -9.87 -0.48 2.64e-20 Calcium levels; CRC cis rs6743376 0.556 rs4849146 chr2:113824840 A/T cg24553058 chr2:113831203 IL1F10 0.43 7.09 0.36 8.4e-12 Inflammatory biomarkers; CRC cis rs950776 0.593 rs6495306 chr15:78865893 C/T cg06917634 chr15:78832804 PSMA4 -0.58 -9.16 -0.45 5.52e-18 Sudden cardiac arrest; CRC cis rs9660180 0.868 rs72634846 chr1:1704915 C/G cg17747265 chr1:1875780 NA -0.74 -12.61 -0.57 5.09e-30 Body mass index; CRC cis rs7666738 0.830 rs115279324 chr4:99042114 T/C cg05340658 chr4:99064831 C4orf37 0.58 8.91 0.44 3.58e-17 Colonoscopy-negative controls vs population controls; CRC cis rs6504249 0.893 rs2521827 chr17:62692728 T/G cg02097616 chr17:62675921 NA 0.52 7.11 0.37 7.1e-12 Joint mobility (Beighton score); CRC cis rs4713118 0.869 rs9366700 chr6:27696951 C/T cg03623178 chr6:28175578 NA 0.66 9.34 0.46 1.46e-18 Parkinson's disease; CRC cis rs1552244 0.935 rs35515831 chr3:10071362 G/A cg16606324 chr3:10149918 C3orf24 0.69 9.36 0.46 1.3e-18 Alzheimer's disease; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg21788396 chr15:78423938 CIB2 -0.43 -6.57 -0.34 1.99e-10 Myopia (pathological); CRC cis rs10504229 0.683 rs11774645 chr8:58132921 G/C cg24829409 chr8:58192753 C8orf71 -0.62 -7.92 -0.4 3.68e-14 Developmental language disorder (linguistic errors); CRC cis rs9733 0.519 rs7529194 chr1:150622620 A/T cg17724175 chr1:150552817 MCL1 0.55 9.19 0.45 4.64e-18 Tonsillectomy; CRC cis rs4594175 1.000 rs4594175 chr14:51606541 C/A cg23942311 chr14:51606299 NA 0.67 11.15 0.52 1.09e-24 Cancer; CRC cis rs4824093 0.535 rs9627797 chr22:50317569 G/A cg22709217 chr22:50311962 ALG12;CRELD2 -0.92 -8.61 -0.43 2.99e-16 Amyotrophic lateral sclerosis (sporadic); CRC cis rs861020 1.000 rs7555285 chr1:209970355 C/G cg05527609 chr1:210001259 C1orf107 -0.78 -10.25 -0.49 1.42e-21 Orofacial clefts; CRC cis rs1448094 0.791 rs11117122 chr12:86337749 A/C cg25456477 chr12:86230367 RASSF9 0.33 5.69 0.3 2.82e-8 Major depressive disorder; CRC cis rs7666738 0.830 rs3911282 chr4:99037602 T/A cg17366294 chr4:99064904 C4orf37 0.44 7.47 0.38 7.18e-13 Colonoscopy-negative controls vs population controls; CRC cis rs2811415 0.531 rs9839861 chr3:127742405 G/T cg13719885 chr3:127795394 NA -0.37 -5.65 -0.3 3.49e-8 Lung function (FEV1/FVC); CRC trans rs12517041 1.000 rs10052994 chr5:23292784 T/C ch.8.1293020R chr8:59333349 UBXN2B -0.56 -6.34 -0.33 7.61e-10 Calcium levels; CRC cis rs2836974 0.666 rs12626405 chr21:40663121 G/T cg06238570 chr21:40685208 BRWD1 -0.81 -13.07 -0.58 1.01e-31 Cognitive function; CRC cis rs763014 0.932 rs2269560 chr16:682442 A/C cg04497992 chr16:616212 NHLRC4 0.43 6.71 0.35 8.33e-11 Height; CRC cis rs7098414 0.511 rs4934126 chr10:82151598 A/G cg00277334 chr10:82204260 NA -0.48 -7.74 -0.39 1.21e-13 Post bronchodilator FEV1; CRC cis rs453301 0.719 rs34004903 chr8:8892604 C/T cg14979609 chr8:8086686 FLJ10661 0.38 6.22 0.32 1.54e-9 Joint mobility (Beighton score); CRC cis rs5167 0.506 rs7257916 chr19:45482884 T/C cg09555818 chr19:45449301 APOC2 -0.33 -5.69 -0.3 2.8e-8 Blood protein levels; CRC cis rs7772486 0.790 rs2249386 chr6:146186611 G/A cg23711669 chr6:146136114 FBXO30 0.75 12.98 0.58 2.16e-31 Lobe attachment (rater-scored or self-reported); CRC cis rs6952808 0.531 rs3778991 chr7:2172455 G/A cg04267008 chr7:1944627 MAD1L1 -0.64 -8.74 -0.43 1.21e-16 Bipolar disorder and schizophrenia; CRC cis rs5753618 0.539 rs4820962 chr22:31689951 A/G cg22777020 chr22:31556080 RNF185 -0.53 -5.9 -0.31 8.8e-9 Colorectal cancer; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg19872317 chr14:65346686 NA 0.5 7.13 0.37 6.35e-12 Response to antipsychotic treatment; CRC cis rs11758351 1.000 rs77957229 chr6:26185226 A/G cg01420254 chr6:26195488 NA 0.84 8.78 0.44 9.23e-17 Gout;Renal underexcretion gout; CRC cis rs1044826 0.642 rs2071388 chr3:139236683 C/T cg00490450 chr3:139108681 COPB2 -0.45 -6.74 -0.35 7.09e-11 Obesity-related traits; CRC cis rs6570726 0.846 rs411468 chr6:145832792 A/G cg23711669 chr6:146136114 FBXO30 0.68 12.16 0.56 2.33e-28 Lobe attachment (rater-scored or self-reported); CRC cis rs4862750 0.837 rs1863404 chr4:187874654 T/C cg11301795 chr4:187892539 NA -0.83 -18.69 -0.72 1.29e-53 Lobe attachment (rater-scored or self-reported); CRC cis rs9487051 0.714 rs1546722 chr6:109625797 A/G cg01475377 chr6:109611718 NA -0.37 -6.52 -0.34 2.66e-10 Reticulocyte fraction of red cells; CRC cis rs7917772 0.503 rs7100753 chr10:104300979 C/T cg04362960 chr10:104952993 NT5C2 -0.41 -5.79 -0.3 1.62e-8 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC cis rs10504229 0.596 rs6991216 chr8:58115586 T/C cg05313129 chr8:58192883 C8orf71 -0.43 -6.11 -0.32 2.74e-9 Developmental language disorder (linguistic errors); CRC cis rs2929278 0.546 rs686666 chr15:44161550 G/A cg02155558 chr15:43621948 ADAL;LCMT2 0.48 6.63 0.34 1.35e-10 Schizophrenia; CRC cis rs9640161 0.659 rs11975886 chr7:150010362 G/A cg13722127 chr7:150037890 RARRES2 0.46 7.49 0.38 6.43e-13 Blood protein levels;Circulating chemerin levels; CRC cis rs3858526 0.917 rs10769386 chr11:5973420 C/T cg05234568 chr11:5960015 NA 0.54 7.01 0.36 1.36e-11 DNA methylation (variation); CRC cis rs1322512 0.920 rs1407487 chr6:152945846 T/C cg03415253 chr6:152958462 SYNE1 -0.41 -6.37 -0.33 6.5e-10 Tonometry; CRC cis rs7216064 0.817 rs28609796 chr17:65855104 T/A cg12091567 chr17:66097778 LOC651250 -0.68 -7.79 -0.39 8.58e-14 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CRC cis rs2290159 0.800 rs5746191 chr3:12658774 G/A cg23032965 chr3:12705835 RAF1 0.49 6.31 0.33 9.24e-10 Cholesterol, total; CRC cis rs12701220 0.655 rs12702117 chr7:1148702 T/C cg00990874 chr7:1149470 C7orf50 -0.7 -9.21 -0.45 4e-18 Bronchopulmonary dysplasia; CRC cis rs1150668 0.796 rs1005125 chr6:28367355 G/A cg06470822 chr6:28175283 NA 0.62 9.27 0.46 2.45e-18 Pubertal anthropometrics; CRC cis rs2836974 0.674 rs1011413 chr21:40638241 A/G cg17971929 chr21:40555470 PSMG1 -0.71 -11.12 -0.52 1.31e-24 Cognitive function; CRC cis rs2288912 0.807 rs7251501 chr19:45455706 C/T cg13119609 chr19:45449297 APOC2 0.31 5.81 0.3 1.5e-8 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs17345786 0.906 rs11710016 chr3:101120030 A/C cg11279151 chr3:101281821 RG9MTD1 0.6 6.99 0.36 1.51e-11 Colonoscopy-negative controls vs population controls; CRC cis rs1218582 0.774 rs1007170 chr1:154881461 G/A cg09359103 chr1:154839909 KCNN3 -0.74 -12.95 -0.58 2.85e-31 Prostate cancer; CRC cis rs11758351 0.660 rs16891446 chr6:26226996 A/C cg10723962 chr6:26240782 HIST1H4F -0.38 -6.09 -0.32 3.14e-9 Gout;Renal underexcretion gout; CRC cis rs6860806 0.507 rs200837 chr5:131699958 G/A cg02033258 chr5:131593261 PDLIM4 0.38 6.3 0.33 9.51e-10 Breast cancer; CRC cis rs2302190 0.882 rs6503859 chr17:56460852 C/G cg12560992 chr17:57184187 TRIM37 0.47 5.75 0.3 2.08e-8 Vitamin D levels; CRC cis rs3820068 0.580 rs12747696 chr1:16002978 A/G cg13390004 chr1:15929781 NA 0.51 7.21 0.37 3.91e-12 Systolic blood pressure; CRC cis rs9925964 0.967 rs1978487 chr16:31129942 C/T cg03418659 chr16:31128414 MYST1 -0.48 -7.01 -0.36 1.37e-11 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg23979971 chr5:138677953 PAIP2 0.37 6.06 0.32 3.63e-9 Obesity-related traits; CRC cis rs2842992 0.915 rs2842980 chr6:160100116 A/T cg19482086 chr6:160211437 TCP1;MRPL18 0.68 8.27 0.41 3.35e-15 Age-related macular degeneration (geographic atrophy); CRC cis rs8060686 0.668 rs2418739 chr16:68092850 G/C cg26727032 chr16:67993705 SLC12A4 -0.62 -9.62 -0.47 1.85e-19 HDL cholesterol;Metabolic syndrome; CRC trans rs6066835 0.572 rs6066804 chr20:47262322 G/A cg21109867 chr19:55897418 RPL28 -0.82 -6.21 -0.32 1.57e-9 Multiple myeloma; CRC cis rs2180341 1.000 rs9398838 chr6:127635285 C/T cg24812749 chr6:127587940 RNF146 0.95 13.75 0.6 2.59e-34 Breast cancer; CRC cis rs6951245 0.872 rs74360401 chr7:1067403 G/A cg20603222 chr7:1096387 C7orf50;GPR146 -0.69 -8.1 -0.41 1.07e-14 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs6076065 0.676 rs1419006 chr20:23336766 C/T cg11657817 chr20:23433608 CST11 0.48 7.2 0.37 4.14e-12 Facial morphology (factor 15, philtrum width); CRC cis rs514406 0.505 rs425520 chr1:53179805 C/G cg25767906 chr1:53392781 SCP2 -0.41 -6.3 -0.33 9.68e-10 Monocyte count; CRC trans rs9291683 0.546 rs12504565 chr4:10045145 G/A cg26043149 chr18:55253948 FECH 0.51 7.63 0.39 2.62e-13 Bone mineral density; CRC cis rs3785574 0.962 rs13030 chr17:61908556 C/T cg22520471 chr17:61851767 DDX42;CCDC47 0.47 6.37 0.33 6.35e-10 Height; CRC cis rs2404602 0.716 rs7164813 chr15:76708066 T/C cg22467129 chr15:76604101 ETFA -0.43 -7.22 -0.37 3.53e-12 Blood metabolite levels; CRC cis rs2239547 0.657 rs12488303 chr3:52862003 G/A cg18404041 chr3:52824283 ITIH1 -0.41 -7.65 -0.39 2.25e-13 Schizophrenia; CRC cis rs2239547 0.522 rs9865094 chr3:52985319 G/C cg15147215 chr3:52552868 STAB1 0.38 5.86 0.31 1.11e-8 Schizophrenia; CRC trans rs116095464 0.558 rs6555056 chr5:226222 T/C cg00938859 chr5:1591904 SDHAP3 0.69 7.55 0.38 4.21e-13 Breast cancer; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg15664899 chr5:133450709 TCF7 0.45 7.07 0.36 9.22e-12 Liver disease severity in Alagille syndrome; CRC cis rs6597981 0.592 rs10902218 chr11:743813 C/T cg01741372 chr11:783889 NA -0.52 -8.68 -0.43 1.88e-16 Breast cancer; CRC cis rs3617 0.625 rs2336558 chr3:52886240 C/T cg11645453 chr3:52864694 ITIH4 -0.46 -9.16 -0.45 5.58e-18 Red blood cell count;Autism spectrum disorder or schizophrenia; CRC cis rs972578 0.967 rs2038061 chr22:43397861 A/G cg01576275 chr22:43409880 NA -0.46 -6.96 -0.36 1.88e-11 Mean platelet volume; CRC cis rs9611565 0.659 rs9607813 chr22:41941479 G/A cg17554472 chr22:41940697 POLR3H -0.57 -6.09 -0.32 3.18e-9 Vitiligo; CRC cis rs10911232 0.507 rs4266836 chr1:183029070 T/G ch.1.3577855R chr1:183094577 LAMC1 0.79 13.18 0.59 3.89e-32 Hypertriglyceridemia; CRC cis rs9311474 0.632 rs6445528 chr3:52572447 C/T cg11645453 chr3:52864694 ITIH4 -0.36 -6.67 -0.35 1.09e-10 Electroencephalogram traits; CRC cis rs7542091 0.666 rs7537070 chr1:210043565 A/G cg05527609 chr1:210001259 C1orf107 -0.44 -5.86 -0.31 1.15e-8 Monobrow; CRC cis rs6754311 0.773 rs309179 chr2:136613780 G/A cg15123519 chr2:136567270 LCT 0.34 6.57 0.34 1.94e-10 Mosquito bite size; CRC cis rs3858526 0.584 rs10734559 chr11:5861788 A/C cg05234568 chr11:5960015 NA -0.64 -9.08 -0.45 1.06e-17 DNA methylation (variation); CRC cis rs6912958 0.500 rs2025486 chr6:87796886 T/C cg08069147 chr6:88032118 GJB7;C6orf162 -0.59 -8.51 -0.42 6.43e-16 Monocyte percentage of white cells; CRC cis rs477895 0.639 rs35858916 chr11:63950529 T/G cg05016508 chr11:63871570 FLRT1;MACROD1 0.54 6.98 0.36 1.62e-11 Mean platelet volume; CRC trans rs5756813 0.754 rs3788529 chr22:38158709 A/G cg19894588 chr14:64061835 NA -0.6 -8.15 -0.41 7.58e-15 Optic cup area;Vertical cup-disc ratio; CRC cis rs3126085 0.935 rs11204952 chr1:152227321 G/A cg09127314 chr1:152161683 NA 0.48 6.18 0.32 1.93e-9 Atopic dermatitis; CRC cis rs208520 0.874 rs208456 chr6:66907942 A/G cg07460842 chr6:66804631 NA -0.92 -11.51 -0.54 5.56e-26 Exhaled nitric oxide output; CRC trans rs10983614 1.000 rs7867776 chr9:120072627 A/G cg20982606 chr12:109535391 UNG 0.43 6.01 0.31 5.04e-9 Survival in pancreatic cancer; CRC cis rs7614311 0.731 rs3774721 chr3:63954649 A/G cg22134162 chr3:63841271 THOC7 -0.57 -5.83 -0.31 1.3e-8 Lung function (FVC);Lung function (FEV1); CRC cis rs6500602 0.727 rs11076837 chr16:4569440 C/T cg14951292 chr16:4525986 HMOX2;NMRAL1 0.56 8.58 0.43 3.85e-16 Schizophrenia; CRC cis rs6502050 0.799 rs9675196 chr17:80096655 C/T cg25804541 chr17:80189381 SLC16A3 -0.32 -6.17 -0.32 1.99e-9 Life satisfaction; CRC cis rs1577917 0.883 rs13212415 chr6:86608083 A/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.45 -5.88 -0.31 9.99e-9 Response to antipsychotic treatment; CRC cis rs3015497 0.616 rs4901043 chr14:51083594 C/T cg09863266 chr14:51125203 SAV1 0.3 5.69 0.3 2.85e-8 Mean platelet volume; CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg11901034 chr3:128598214 ACAD9 0.41 6.31 0.33 8.82e-10 Obesity-related traits; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg14878150 chr12:101673760 UTP20 0.51 7.33 0.37 1.83e-12 Response to antipsychotic treatment; CRC cis rs1577917 1.000 rs35760725 chr6:86648985 C/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.51 -6.88 -0.35 3.08e-11 Response to antipsychotic treatment; CRC cis rs6860806 0.507 rs272883 chr5:131668698 A/G cg04518342 chr5:131593106 PDLIM4 0.42 6.94 0.36 2.03e-11 Breast cancer; CRC cis rs1475911 0.744 rs12481958 chr21:43517269 A/G cg19766460 chr21:43528205 UMODL1;C21orf128 0.57 7.09 0.36 8.16e-12 IgG glycosylation; CRC cis rs2976388 0.609 rs1594999 chr8:143790574 G/A cg22687807 chr8:143858763 LYNX1 0.51 9.19 0.45 4.69e-18 Urinary tract infection frequency; CRC cis rs6598955 0.670 rs10794525 chr1:26537193 C/A cg04990556 chr1:26633338 UBXN11 -0.79 -13.27 -0.59 1.76e-32 Obesity-related traits; CRC cis rs9463078 0.547 rs9472360 chr6:44747410 T/C cg25276700 chr6:44698697 NA 0.3 7.76 0.39 1.09e-13 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; CRC cis rs2115536 1.000 rs2903105 chr15:80189523 C/G cg00225070 chr15:80189496 MTHFS 0.51 8.11 0.41 9.81e-15 Eosinophil counts;Eosinophil percentage of white cells;Sum eosinophil basophil counts;Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; CRC cis rs7809950 1.000 rs2712214 chr7:107188031 G/A cg23024343 chr7:107201750 COG5 -0.62 -8.79 -0.44 8.52e-17 Coronary artery disease; CRC cis rs1552244 0.832 rs61056817 chr3:10027641 C/T cg10729496 chr3:10149963 C3orf24 0.5 6.12 0.32 2.72e-9 Alzheimer's disease; CRC cis rs477895 0.629 rs7130030 chr11:63933733 T/G cg19465662 chr11:63993652 NUDT22;TRPT1 0.71 8.75 0.43 1.12e-16 Mean platelet volume; CRC cis rs789859 0.611 rs1077729 chr3:194418126 A/G cg21106136 chr3:194405973 FAM43A 0.44 6.29 0.33 1.03e-9 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; CRC cis rs909002 0.789 rs56074668 chr1:32123801 T/C cg13919466 chr1:32135498 COL16A1 -0.37 -7.08 -0.36 8.77e-12 Intelligence (multi-trait analysis); CRC cis rs651907 0.557 rs11710533 chr3:101351472 G/A cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.64 8.52 0.43 5.72e-16 Colorectal cancer; CRC cis rs875971 0.895 rs12531677 chr7:65769086 G/A cg12463550 chr7:65579703 CRCP -0.5 -6.78 -0.35 5.73e-11 Aortic root size; CRC cis rs4555082 0.830 rs2816614 chr14:105727359 C/T cg13114125 chr14:105738426 BRF1 -0.81 -11.69 -0.54 1.2e-26 Mean platelet volume;Platelet distribution width; CRC trans rs57221529 0.766 rs4957053 chr5:575927 T/C cg25482853 chr8:67687455 SGK3 1.25 14.99 0.64 4.45e-39 Lung disease severity in cystic fibrosis; CRC cis rs6121246 0.909 rs6060979 chr20:30417522 C/T cg18721089 chr20:30220636 NA -0.35 -5.85 -0.31 1.2e-8 Mean corpuscular hemoglobin; CRC cis rs2153535 0.580 rs763376 chr6:8492776 G/A cg07606381 chr6:8435919 SLC35B3 0.66 10.66 0.51 5.31e-23 Motion sickness; CRC cis rs826838 0.967 rs826855 chr12:39114888 T/C cg26384229 chr12:38710491 ALG10B -0.61 -9.36 -0.46 1.28e-18 Heart rate; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg15025054 chr1:212964885 TATDN3;NSL1 0.49 6.2 0.32 1.7e-9 Thyroid stimulating hormone; CRC cis rs7705042 0.865 rs4385236 chr5:141513396 G/A cg07392085 chr5:141489673 NDFIP1 0.45 7.26 0.37 2.75e-12 Asthma; CRC trans rs9858542 0.953 rs7646366 chr3:49470668 G/A cg21659725 chr3:3221576 CRBN -0.65 -8.85 -0.44 5.43e-17 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs1577917 0.876 rs11752223 chr6:86573394 T/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.49 -6.53 -0.34 2.47e-10 Response to antipsychotic treatment; CRC cis rs6087990 0.806 rs2424918 chr20:31382770 C/T cg13636640 chr20:31349939 DNMT3B 0.84 17.05 0.68 3.76e-47 Ulcerative colitis; CRC cis rs860295 0.651 rs6692183 chr1:155304327 T/G cg02153340 chr1:155202674 NA -0.5 -6.08 -0.32 3.35e-9 Body mass index; CRC cis rs7635838 0.617 rs346085 chr3:11282724 T/C cg00170343 chr3:11313890 ATG7 0.57 8.91 0.44 3.63e-17 HDL cholesterol; CRC cis rs2204008 0.837 rs11168334 chr12:37961768 A/G cg26384229 chr12:38710491 ALG10B 0.68 9.08 0.45 1.03e-17 Bladder cancer; CRC cis rs2949837 0.581 rs1496499 chr7:45979023 T/G cg06713098 chr7:45960367 IGFBP3 0.44 6.87 0.35 3.32e-11 Sitting height ratio; CRC trans rs1728785 1.000 rs698728 chr16:68625253 T/C cg04657470 chr2:198365150 HSPE1;HSPD1 0.59 7.19 0.37 4.49e-12 Ulcerative colitis; CRC cis rs939584 1.000 rs6719980 chr2:651507 T/C cg03610516 chr2:642275 NA -0.43 -5.94 -0.31 7.19e-9 Body mass index; CRC trans rs1455244 0.700 rs7229302 chr18:11508904 G/T cg08279428 chr12:31479139 FAM60A 0.39 6.01 0.31 4.9e-9 Schizophrenia; CRC cis rs6484504 0.576 rs2150213 chr11:31244634 A/G cg14844989 chr11:31128820 NA -0.34 -5.99 -0.31 5.5e-9 Red blood cell count; CRC cis rs7220401 0.789 rs3760456 chr17:27948844 C/T cg26525008 chr17:28256777 EFCAB5;SSH2 -0.66 -10.72 -0.51 3.46e-23 Coronary artery disease; CRC cis rs10991814 1.000 rs74508579 chr9:93959594 C/T cg14446406 chr9:93919335 NA 0.56 6.05 0.32 4e-9 Neutrophil percentage of granulocytes; CRC cis rs6831352 0.879 rs7672728 chr4:100055173 A/G cg13256891 chr4:100009986 ADH5 -0.66 -8.89 -0.44 4.04e-17 Alcohol dependence; CRC cis rs3020333 0.846 rs3020335 chr6:152013223 G/T cg22157087 chr6:152012887 ESR1 0.55 8.23 0.41 4.52e-15 Total body bone mineral density; CRC cis rs6076065 0.723 rs2424532 chr20:23373877 G/A cg11657817 chr20:23433608 CST11 0.45 6.68 0.35 1.01e-10 Facial morphology (factor 15, philtrum width); CRC cis rs12477438 0.834 rs11903311 chr2:99701807 T/C cg14399236 chr2:99771627 LIPT1;TSGA10 -0.62 -8.73 -0.43 1.26e-16 Chronic sinus infection; CRC cis rs7829975 0.582 rs448231 chr8:8790059 A/T cg06636001 chr8:8085503 FLJ10661 -0.47 -6.87 -0.35 3.21e-11 Mood instability; CRC cis rs9527 0.590 rs1541213 chr10:104885330 A/G cg04362960 chr10:104952993 NT5C2 0.6 8.32 0.42 2.32e-15 Arsenic metabolism; CRC cis rs1577917 0.771 rs2758844 chr6:86330115 T/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.7 -9.25 -0.45 3e-18 Response to antipsychotic treatment; CRC cis rs12325245 0.536 rs12924708 chr16:58567643 G/A cg19824325 chr16:58548873 SETD6 0.91 6.09 0.32 3.08e-9 Schizophrenia; CRC cis rs2481665 0.772 rs6661862 chr1:62534854 A/C cg18591186 chr1:62594603 INADL 0.54 7.66 0.39 2.17e-13 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs2976388 1.000 rs1045574 chr8:143763958 C/T cg15511327 chr8:143859410 LYNX1 -0.32 -5.76 -0.3 1.92e-8 Urinary tract infection frequency; CRC cis rs9903692 0.909 rs12952163 chr17:46159391 C/T cg21215337 chr17:46176117 CBX1 0.42 7.71 0.39 1.5e-13 Pulse pressure; CRC cis rs11971779 0.584 rs6962029 chr7:139034719 T/C cg23387468 chr7:139079360 LUC7L2 0.4 6.9 0.36 2.76e-11 Diisocyanate-induced asthma; CRC trans rs6601327 0.602 rs7820917 chr8:9647868 C/T cg06636001 chr8:8085503 FLJ10661 0.5 7.5 0.38 5.94e-13 Multiple myeloma (hyperdiploidy); CRC trans rs11039798 0.512 rs28453037 chr11:49006929 C/A cg03929089 chr4:120376271 NA 0.6 6.13 0.32 2.51e-9 Axial length; CRC cis rs2032447 0.670 rs71557318 chr6:26118570 T/C cg26028573 chr6:26043587 HIST1H2BB -0.39 -5.75 -0.3 2.09e-8 Intelligence (multi-trait analysis); CRC cis rs6028335 0.674 rs59072291 chr20:37622010 T/A cg16355469 chr20:37678765 NA 0.46 5.61 0.3 4.34e-8 Alcohol and nicotine co-dependence; CRC cis rs10256972 0.567 rs2960835 chr7:1202963 A/G cg26608667 chr7:1196370 ZFAND2A 0.43 6.99 0.36 1.57e-11 Longevity;Endometriosis; CRC trans rs35110281 0.633 rs762400 chr21:45113629 C/G cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO -0.37 -6.1 -0.32 2.95e-9 Mean corpuscular volume; CRC cis rs6860806 0.507 rs273915 chr5:131660119 G/C cg20512303 chr5:131592959 PDLIM4 0.39 6.81 0.35 4.67e-11 Breast cancer; CRC cis rs6582630 0.519 rs4405392 chr12:38293661 A/C cg13010199 chr12:38710504 ALG10B 0.46 6.25 0.33 1.25e-9 Drug-induced liver injury (flucloxacillin); CRC cis rs9491140 0.539 rs980658 chr6:124690371 G/A cg22366943 chr6:124882293 NKAIN2 0.53 7.98 0.4 2.46e-14 Neuroticism; CRC cis rs6831352 0.918 rs7670241 chr4:100059619 G/T cg12011299 chr4:100065546 ADH4 -0.49 -9.27 -0.45 2.61e-18 Alcohol dependence; CRC cis rs561341 0.882 rs2521594 chr17:30302087 C/T cg23018236 chr17:30244563 NA -0.65 -7.71 -0.39 1.48e-13 Hip circumference adjusted for BMI; CRC cis rs4563143 0.514 rs73029081 chr19:29295583 C/G cg14983838 chr19:29218262 NA 0.52 6.94 0.36 2.04e-11 Methadone dose in opioid dependence; CRC trans rs8073060 0.586 rs225294 chr17:33925762 G/A cg19694781 chr19:47549865 TMEM160 -1.01 -13.92 -0.61 5.81e-35 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; CRC cis rs9309711 0.544 rs9752130 chr2:3488502 A/G cg15506890 chr2:3487001 NA -0.58 -9.22 -0.45 3.56e-18 Neurofibrillary tangles; CRC cis rs6831352 0.918 rs13112176 chr4:100055825 G/A cg13256891 chr4:100009986 ADH5 -0.66 -8.89 -0.44 4.04e-17 Alcohol dependence; CRC cis rs2932538 0.922 rs6537745 chr1:113154080 T/C cg22162597 chr1:113214053 CAPZA1 0.61 8.95 0.44 2.68e-17 Systolic blood pressure;Diastolic blood pressure;Hypertension;Blood pressure; CRC cis rs3857067 1.000 rs6532462 chr4:95026833 G/T cg11021082 chr4:95130006 SMARCAD1 -0.41 -6.22 -0.32 1.55e-9 QT interval; CRC cis rs10461617 0.541 rs860581 chr5:56150537 A/G cg12311346 chr5:56204834 C5orf35 -0.66 -6.87 -0.35 3.26e-11 Type 2 diabetes; CRC cis rs1799949 0.965 rs34616041 chr17:41188786 G/A cg05368731 chr17:41323189 NBR1 0.67 9.58 0.47 2.42e-19 Menopause (age at onset); CRC cis rs614226 1.000 rs12310837 chr12:120880572 C/T cg27489772 chr12:121021490 NA 0.47 6.37 0.33 6.48e-10 Type 1 diabetes nephropathy; CRC cis rs9682041 0.932 rs7631221 chr3:170069893 A/G cg11886554 chr3:170076028 SKIL 0.67 7.55 0.38 4.29e-13 Glomerular filtration rate in non diabetics (creatinine);Glomerular filtration rate (creatinine); CRC cis rs10479542 0.896 rs4701130 chr5:178982416 C/T cg26516362 chr5:178986906 RUFY1 -0.38 -7.02 -0.36 1.29e-11 Lung cancer; CRC cis rs1832871 0.521 rs62437409 chr6:158820221 G/C cg14153777 chr6:158651016 NA 0.4 5.61 0.3 4.26e-8 Height; CRC cis rs2933343 0.649 rs1683786 chr3:128626952 T/C cg11901034 chr3:128598214 ACAD9 -0.56 -8.11 -0.41 1.01e-14 IgG glycosylation; CRC cis rs1451375 0.572 rs745042 chr7:50544138 A/G cg18232548 chr7:50535776 DDC -0.44 -5.8 -0.3 1.57e-8 Malaria; CRC cis rs2180341 0.842 rs6569476 chr6:127553539 G/A cg24812749 chr6:127587940 RNF146 0.84 10.26 0.49 1.27e-21 Breast cancer; CRC cis rs6604026 0.740 rs10782945 chr1:93304272 C/T cg17283838 chr1:93427260 FAM69A -0.49 -6.96 -0.36 1.8e-11 Multiple sclerosis; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg04298196 chr4:120549256 PDE5A 0.39 5.96 0.31 6.33e-9 Response to antipsychotic treatment; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg13906045 chr3:14166433 CHCHD4;TMEM43 0.42 6.59 0.34 1.7e-10 Intelligence (multi-trait analysis); CRC trans rs7565792 1.000 rs7565792 chr2:48649705 A/G cg19646200 chr12:132886954 GALNT9 0.37 6.12 0.32 2.65e-9 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs7618915 0.571 rs6778844 chr3:52596398 C/T cg11645453 chr3:52864694 ITIH4 -0.34 -5.92 -0.31 8.11e-9 Bipolar disorder; CRC trans rs2055729 0.677 rs6601393 chr8:9741035 G/A cg06636001 chr8:8085503 FLJ10661 -0.53 -6.79 -0.35 5.4e-11 Multiple myeloma (hyperdiploidy); CRC cis rs34375054 0.738 rs10846834 chr12:125625570 A/G cg25124228 chr12:125621409 AACS -0.59 -9.43 -0.46 7.47e-19 Post bronchodilator FEV1/FVC ratio; CRC cis rs637571 0.522 rs550435 chr11:65732651 G/A cg02427764 chr11:65769310 BANF1;EIF1AD 0.4 5.64 0.3 3.63e-8 Eosinophil percentage of white cells; CRC cis rs1018836 0.739 rs4734247 chr8:91569144 A/G cg16814680 chr8:91681699 NA -0.6 -9.12 -0.45 7.49e-18 Ejection fraction in Tripanosoma cruzi seropositivity; CRC cis rs4731207 0.698 rs2402755 chr7:124448608 T/C cg23710748 chr7:124431027 NA 0.37 5.96 0.31 6.53e-9 Cutaneous malignant melanoma; CRC cis rs853679 0.585 rs201004 chr6:27804934 T/C cg03623178 chr6:28175578 NA 0.58 6.39 0.33 5.76e-10 Depression; CRC cis rs10493773 0.532 rs12064199 chr1:86187073 A/T cg00734567 chr1:86172782 ZNHIT6 -0.38 -5.99 -0.31 5.55e-9 Urate levels in overweight individuals; CRC cis rs4731207 0.662 rs7357296 chr7:124532716 C/T cg23710748 chr7:124431027 NA -0.38 -6.06 -0.32 3.65e-9 Cutaneous malignant melanoma; CRC cis rs28386778 0.897 rs1062791 chr17:61896487 C/T cg23090583 chr17:61904693 PSMC5;FTSJ3 1.05 20.54 0.75 6.37e-61 Prudent dietary pattern; CRC cis rs7772486 0.686 rs4896827 chr6:145953338 T/A cg13319975 chr6:146136371 FBXO30 -0.44 -6.66 -0.34 1.15e-10 Lobe attachment (rater-scored or self-reported); CRC trans rs2930353 0.765 rs2975366 chr8:3720473 C/T cg02274509 chr10:127407819 C10orf137 0.43 5.97 0.31 6.16e-9 Colonoscopy-negative controls vs population controls; CRC cis rs644799 0.635 rs10831428 chr11:95508404 C/A cg03916912 chr11:95522834 CEP57;FAM76B 0.86 15.76 0.66 4.41e-42 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs3820068 0.603 rs1122387 chr1:15947282 T/C cg27534772 chr1:16042836 PLEKHM2 0.55 11.0 0.52 3.66e-24 Systolic blood pressure; CRC cis rs6964587 0.626 rs1011372 chr7:91509867 T/C cg17063962 chr7:91808500 NA -0.58 -9.22 -0.45 3.52e-18 Breast cancer; CRC cis rs9381040 0.655 rs2268192 chr6:41024626 T/C cg04346459 chr6:41068666 NFYA;LOC221442 -0.41 -6.14 -0.32 2.43e-9 Alzheimer's disease (late onset); CRC cis rs6952808 0.964 rs6945719 chr7:1932688 G/A cg00106254 chr7:1943704 MAD1L1 -0.52 -7.7 -0.39 1.66e-13 Bipolar disorder and schizophrenia; CRC cis rs6662572 0.737 rs6429593 chr1:46505235 T/G cg03123370 chr1:45965343 CCDC163P;MMACHC 0.45 5.84 0.31 1.27e-8 Blood protein levels; CRC cis rs875971 0.577 rs35072105 chr7:65609817 A/G cg11764359 chr7:65958608 NA -0.55 -8.52 -0.43 5.86e-16 Aortic root size; CRC cis rs6076065 0.723 rs2424531 chr20:23372754 C/T cg11657817 chr20:23433608 CST11 -0.44 -6.5 -0.34 2.92e-10 Facial morphology (factor 15, philtrum width); CRC cis rs4838594 0.549 rs3888909 chr10:49687284 C/T cg17291251 chr10:49678358 ARHGAP22 0.4 6.19 0.32 1.76e-9 Daytime sleep phenotypes; CRC cis rs1799949 0.929 rs799906 chr17:41278116 T/C cg23758822 chr17:41437982 NA 0.85 15.74 0.66 5.32e-42 Menopause (age at onset); CRC cis rs5750830 0.594 rs9611169 chr22:39783027 C/T cg11247378 chr22:39784982 NA -0.41 -7.67 -0.39 2e-13 Intelligence (multi-trait analysis); CRC cis rs9491140 0.539 rs11154231 chr6:124687586 T/C cg05308643 chr6:124982296 NKAIN2 0.48 6.67 0.35 1.09e-10 Neuroticism; CRC cis rs7224685 0.871 rs8081968 chr17:3984117 C/T cg05562828 chr17:3906858 NA 0.47 7.59 0.39 3.41e-13 Type 2 diabetes; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg05756109 chr10:103347662 POLL;RP11-529I10.4 0.42 6.08 0.32 3.41e-9 Response to antipsychotic treatment; CRC cis rs2228479 0.717 rs17226274 chr16:89850170 C/T cg06656553 chr16:89960601 TCF25 -0.71 -6.22 -0.32 1.54e-9 Skin colour saturation; CRC cis rs7246657 0.943 rs10420754 chr19:37959372 C/G cg23950597 chr19:37808831 NA -0.49 -6.05 -0.32 3.93e-9 Coronary artery calcification; CRC cis rs8014204 0.781 rs10143492 chr14:75212114 G/C cg08847533 chr14:75593920 NEK9 0.4 5.92 0.31 8.2e-9 Caffeine consumption; CRC cis rs7618915 0.547 rs3755806 chr3:52643685 C/T cg07507251 chr3:52567010 NT5DC2 -0.43 -6.25 -0.33 1.27e-9 Bipolar disorder; CRC cis rs1577917 0.917 rs1584273 chr6:86524577 C/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.49 -6.58 -0.34 1.82e-10 Response to antipsychotic treatment; CRC cis rs10911232 0.507 rs6672306 chr1:183058898 C/T ch.1.3577855R chr1:183094577 LAMC1 0.84 14.75 0.63 3.64e-38 Hypertriglyceridemia; CRC cis rs6951245 0.935 rs79143504 chr7:1110212 A/G cg22907277 chr7:1156413 C7orf50 0.75 7.68 0.39 1.78e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs62458065 0.850 rs73096034 chr7:32472048 A/G cg20159608 chr7:32802032 NA -0.55 -6.56 -0.34 2.11e-10 Metabolite levels (HVA/MHPG ratio); CRC cis rs10028773 0.515 rs9994651 chr4:120587803 C/T cg10183150 chr4:120222239 C4orf3 -0.33 -5.97 -0.31 6.13e-9 Educational attainment; CRC cis rs7020830 0.931 rs7034554 chr9:37081301 A/G cg14294708 chr9:37120828 ZCCHC7 1.18 26.31 0.82 6.44e-83 Schizophrenia; CRC cis rs7613875 0.620 rs11721204 chr3:49982765 C/T cg24308560 chr3:49941425 MST1R -0.46 -6.93 -0.36 2.22e-11 Body mass index; CRC cis rs2996428 0.667 rs17412654 chr1:3758493 T/C cg17848003 chr1:3704513 LRRC47 0.4 5.7 0.3 2.66e-8 Red cell distribution width; CRC cis rs2075371 0.897 rs12667905 chr7:134000812 A/C cg20476274 chr7:133979776 SLC35B4 0.74 12.29 0.56 8.24e-29 Mean platelet volume; CRC cis rs6952808 0.609 rs6944877 chr7:1952582 T/G cg02951883 chr7:2050386 MAD1L1 -0.53 -8.69 -0.43 1.74e-16 Bipolar disorder and schizophrenia; CRC cis rs910316 0.875 rs12588099 chr14:75594462 A/T cg08847533 chr14:75593920 NEK9 0.96 18.28 0.71 5.33e-52 Height; CRC cis rs3785888 0.569 rs1838105 chr17:45008935 A/G cg16759221 chr17:45003025 GOSR2 0.58 8.67 0.43 1.96e-16 Cleft lip with or without cleft palate; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg00082939 chr10:77165293 C10orf41 0.34 6.71 0.35 8.66e-11 Liver disease severity in Alagille syndrome; CRC cis rs7044106 0.762 rs10760112 chr9:123467570 C/T cg14255062 chr9:123606675 PSMD5;LOC253039 0.45 6.82 0.35 4.31e-11 Hip circumference adjusted for BMI; CRC cis rs1707322 0.721 rs6429574 chr1:46134054 A/G cg03146154 chr1:46216737 IPP 0.66 9.71 0.47 8.86e-20 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs67478160 0.643 rs4906369 chr14:104242458 T/C cg08213375 chr14:104286397 PPP1R13B 0.65 13.69 0.6 4.35e-34 Schizophrenia; CRC cis rs4638749 1.000 rs10209928 chr2:108863898 C/T cg25838818 chr2:108905173 SULT1C2 -0.37 -6.07 -0.32 3.57e-9 Blood pressure; CRC cis rs7772486 0.754 rs702304 chr6:145990797 A/G cg23711669 chr6:146136114 FBXO30 -0.75 -12.7 -0.57 2.35e-30 Lobe attachment (rater-scored or self-reported); CRC cis rs4713118 0.869 rs9461400 chr6:27700559 A/G cg21251018 chr6:28226885 NKAPL 0.38 5.71 0.3 2.5e-8 Parkinson's disease; CRC cis rs12286929 0.661 rs7947402 chr11:115088420 T/C cg04055981 chr11:115044050 NA 0.37 5.8 0.3 1.55e-8 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC trans rs1864585 0.520 rs73208791 chr8:10680338 T/C cg26278703 chr11:58910052 FAM111A 0.56 6.55 0.34 2.24e-10 Neutrophil percentage of white cells;Lymphocyte percentage of white cells; CRC cis rs1448094 0.511 rs2405621 chr12:86149336 A/T cg18827107 chr12:86230957 RASSF9 0.39 6.08 0.32 3.3e-9 Major depressive disorder; CRC cis rs7666738 0.830 rs6532719 chr4:99043691 A/G cg05340658 chr4:99064831 C4orf37 0.58 8.89 0.44 4.2e-17 Colonoscopy-negative controls vs population controls; CRC cis rs832540 0.556 rs4146565 chr5:56093825 T/C cg12311346 chr5:56204834 C5orf35 -0.49 -7.28 -0.37 2.43e-12 Coronary artery disease; CRC cis rs4862750 0.794 rs1030382 chr4:187903782 T/G cg03452623 chr4:187889614 NA -0.93 -20.68 -0.75 1.89e-61 Lobe attachment (rater-scored or self-reported); CRC cis rs1107366 0.750 rs9825571 chr3:125900161 A/G cg21601837 chr3:125900065 ALDH1L1 -0.42 -6.86 -0.35 3.52e-11 Metabolite levels; CRC cis rs28386778 0.704 rs1051688 chr17:62006433 G/C cg22520471 chr17:61851767 DDX42;CCDC47 -0.56 -8.16 -0.41 7.26e-15 Prudent dietary pattern; CRC cis rs2153535 0.601 rs4960414 chr6:8438541 A/G cg07606381 chr6:8435919 SLC35B3 0.68 10.89 0.51 8.99e-24 Motion sickness; CRC cis rs7618915 0.501 rs12635140 chr3:52738165 C/T cg15147215 chr3:52552868 STAB1 0.63 10.64 0.51 6.46e-23 Bipolar disorder; CRC cis rs10504229 0.683 rs56408763 chr8:58137276 G/A cg05313129 chr8:58192883 C8orf71 -0.43 -6.11 -0.32 2.74e-9 Developmental language disorder (linguistic errors); CRC trans rs10983614 1.000 rs7867776 chr9:120072627 A/G cg01704976 chr3:52273381 TWF2 0.44 6.24 0.33 1.36e-9 Survival in pancreatic cancer; CRC cis rs78456975 1.000 rs13413356 chr2:1553849 G/T cg01028140 chr2:1542097 TPO -0.55 -5.74 -0.3 2.15e-8 Placebo response in major depressive disorder (% change in symptom score); CRC cis rs1534166 0.647 rs9853615 chr3:133519981 C/T cg27366882 chr3:133540807 NA 0.58 8.52 0.42 6e-16 Alcohol consumption (transferrin glycosylation); CRC cis rs881375 0.967 rs1014529 chr9:123684943 C/G cg09586646 chr9:123605570 PSMD5;LOC253039 0.46 6.16 0.32 2.15e-9 Rheumatoid arthritis; CRC cis rs6456156 0.586 rs12213683 chr6:167460718 G/A cg07741184 chr6:167504864 NA 0.39 6.9 0.36 2.63e-11 Primary biliary cholangitis; CRC cis rs950169 0.920 rs17300048 chr15:84749477 C/T cg24253500 chr15:84953950 NA 0.38 6.44 0.33 4.32e-10 Schizophrenia; CRC cis rs344364 0.511 rs1657133 chr16:1950300 A/G cg09830162 chr16:1889614 FAHD1;C16orf73 -0.77 -9.36 -0.46 1.32e-18 Glomerular filtration rate in chronic kidney disease; CRC cis rs921968 0.541 rs599973 chr2:219387273 C/G cg02176678 chr2:219576539 TTLL4 0.54 8.68 0.43 1.81e-16 Mean corpuscular hemoglobin concentration; CRC cis rs490234 0.871 rs13288032 chr9:128255582 T/A cg14078157 chr9:128172775 NA -0.35 -5.85 -0.31 1.16e-8 Mean arterial pressure; CRC cis rs2991971 0.967 rs10789465 chr1:45971759 T/C cg03123370 chr1:45965343 CCDC163P;MMACHC -0.39 -6.06 -0.32 3.65e-9 High light scatter reticulocyte count; CRC cis rs5750830 0.621 rs5750810 chr22:39792943 A/G cg05872129 chr22:39784769 NA -0.59 -10.94 -0.52 5.92e-24 Intelligence (multi-trait analysis); CRC cis rs908922 0.676 rs4845789 chr1:152528100 A/G cg09873164 chr1:152488093 CRCT1 0.36 6.13 0.32 2.48e-9 Hair morphology; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg01600100 chr12:96794307 CDK17 0.37 6.14 0.32 2.36e-9 Liver disease severity in Alagille syndrome; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg05147328 chr17:79849438 ANAPC11;THOC4 0.47 6.03 0.32 4.44e-9 Thyroid stimulating hormone; CRC cis rs7666738 0.791 rs6853608 chr4:99047916 A/G cg17366294 chr4:99064904 C4orf37 0.45 7.75 0.39 1.16e-13 Colonoscopy-negative controls vs population controls; CRC cis rs10256972 0.516 rs12702081 chr7:1141528 T/C cg07308232 chr7:1071921 C7orf50 -0.45 -6.12 -0.32 2.63e-9 Longevity;Endometriosis; CRC cis rs6502050 0.835 rs8078795 chr17:80126320 C/T cg22110888 chr17:80059540 CCDC57 0.41 6.54 0.34 2.39e-10 Life satisfaction; CRC cis rs514406 0.929 rs555741 chr1:53318851 T/G cg25767906 chr1:53392781 SCP2 -0.45 -7.35 -0.38 1.54e-12 Monocyte count; CRC cis rs6500602 0.787 rs7204624 chr16:4459834 A/G cg08645402 chr16:4508243 NA 0.55 7.52 0.38 5.22e-13 Schizophrenia; CRC cis rs57221529 0.709 rs72703034 chr5:577101 C/T cg16447950 chr5:562315 NA -0.83 -10.81 -0.51 1.71e-23 Lung disease severity in cystic fibrosis; CRC cis rs6484504 0.553 rs2183484 chr11:31259370 G/A cg14844989 chr11:31128820 NA -0.34 -5.9 -0.31 9.06e-9 Red blood cell count; CRC cis rs3858526 0.920 rs10742832 chr11:5926020 C/G cg02574844 chr11:5959923 NA -0.41 -5.69 -0.3 2.87e-8 DNA methylation (variation); CRC cis rs8072100 0.701 rs8078309 chr17:45774072 T/C cg19784903 chr17:45786737 TBKBP1 -0.35 -5.76 -0.3 1.91e-8 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs10540 1.000 rs12417570 chr11:462684 C/T cg03576123 chr11:487126 PTDSS2 -1.12 -10.92 -0.52 7.06e-24 Body mass index; CRC cis rs8103278 1.000 rs7258283 chr19:46335511 C/T cg14061069 chr19:46274453 DMPK -0.55 -8.08 -0.41 1.28e-14 Coronary artery disease; CRC cis rs6502050 0.769 rs11658272 chr17:80084596 C/T cg25804541 chr17:80189381 SLC16A3 0.31 5.9 0.31 8.94e-9 Life satisfaction; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg21308919 chr4:140619560 MGST2 -0.43 -6.75 -0.35 6.67e-11 Liver disease severity in Alagille syndrome; CRC cis rs4692589 0.581 rs6821641 chr4:170960193 C/T cg19918862 chr4:170955249 NA 0.55 7.26 0.37 2.73e-12 Anxiety disorder; CRC cis rs9547692 0.938 rs55639205 chr13:37469994 A/C cg01493522 chr13:37497338 NA -0.53 -7.32 -0.37 1.97e-12 Coronary artery disease; CRC cis rs10924970 1.000 rs10924870 chr1:235359782 C/T cg26050004 chr1:235667680 B3GALNT2 -0.38 -5.72 -0.3 2.42e-8 Asthma; CRC cis rs9649213 0.593 rs3801263 chr7:97965016 A/G cg00277769 chr7:97922759 BAIAP2L1 -0.59 -10.17 -0.49 2.58e-21 Prostate cancer (SNP x SNP interaction); CRC cis rs2836974 0.932 rs56306759 chr21:40608106 G/A cg11890956 chr21:40555474 PSMG1 1.09 18.64 0.72 1.93e-53 Cognitive function; CRC cis rs10791323 0.569 rs10791328 chr11:133713730 A/G cg03690763 chr11:133734501 NA -0.36 -6.04 -0.32 4.16e-9 Childhood ear infection; CRC cis rs478304 0.654 rs1074155 chr11:65458197 C/T cg05805236 chr11:65401703 PCNXL3 0.4 6.4 0.33 5.33e-10 Acne (severe); CRC cis rs4862750 0.957 rs6858853 chr4:187903412 A/C cg22105103 chr4:187893119 NA -0.61 -10.86 -0.51 1.14e-23 Lobe attachment (rater-scored or self-reported); CRC cis rs3008870 0.755 rs10789219 chr1:67417742 A/C cg08660285 chr1:67390436 MIER1;WDR78 0.54 7.63 0.39 2.59e-13 Lymphocyte percentage of white cells; CRC cis rs1223397 1.000 rs1223403 chr6:13271812 G/A cg20827128 chr6:13274284 PHACTR1 0.57 6.96 0.36 1.8e-11 Blood pressure; CRC cis rs11123170 0.640 rs931472 chr2:113969948 C/T cg21550016 chr2:113992930 PAX8;LOC440839;LOC654433 -0.58 -7.74 -0.39 1.23e-13 Renal function-related traits (BUN); CRC cis rs9914988 0.559 rs1109024 chr17:27189971 C/T cg12682573 chr17:27188876 MIR451;MIR144 -0.6 -8.94 -0.44 2.83e-17 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs11123610 0.520 rs66646194 chr2:3720420 G/A cg00999904 chr2:3704751 ALLC -0.53 -6.68 -0.35 1.04e-10 Response to inhaled corticosteroid treatment in asthma (change in FEV1); CRC cis rs72781680 0.898 rs72780118 chr2:23994431 G/A cg08917208 chr2:24149416 ATAD2B 0.87 8.46 0.42 8.88e-16 Lymphocyte counts; CRC cis rs9326248 1.000 rs3736120 chr11:117032125 G/T cg11861562 chr11:117069780 TAGLN 0.41 9.24 0.45 3.12e-18 Blood protein levels; CRC cis rs6952808 0.823 rs10950448 chr7:1966492 G/C cg02951883 chr7:2050386 MAD1L1 -0.72 -11.05 -0.52 2.27e-24 Bipolar disorder and schizophrenia; CRC cis rs3767633 0.925 rs6427639 chr1:161866372 C/A cg09175582 chr1:161736000 ATF6 0.7 6.29 0.33 1.03e-9 IgG glycosylation; CRC cis rs7666738 0.830 rs28867087 chr4:98880349 T/A cg17366294 chr4:99064904 C4orf37 0.42 6.9 0.36 2.61e-11 Colonoscopy-negative controls vs population controls; CRC cis rs6570726 0.791 rs370112 chr6:145859853 T/G cg13319975 chr6:146136371 FBXO30 -0.47 -7.01 -0.36 1.34e-11 Lobe attachment (rater-scored or self-reported); CRC cis rs6860806 0.507 rs270606 chr5:131650867 A/G cg18758796 chr5:131593413 PDLIM4 0.43 6.81 0.35 4.59e-11 Breast cancer; CRC cis rs7726839 0.561 rs72703058 chr5:584519 G/A cg09021430 chr5:549028 NA -0.86 -10.97 -0.52 4.69e-24 Obesity-related traits; CRC cis rs2857891 1.000 rs2638092 chr11:6961746 G/A cg22096450 chr11:6947773 ZNF215 0.61 6.36 0.33 6.71e-10 Response to cytadine analogues (cytosine arabinoside); CRC cis rs11212617 0.935 rs621947 chr11:108165219 T/C cg01991180 chr11:108092276 ATM;NPAT 0.41 5.71 0.3 2.58e-8 Response to metformin in type 2 diabetes (glycemic); CRC cis rs8180040 0.726 rs61729713 chr3:47027192 A/G cg27129171 chr3:47204927 SETD2 -0.65 -10.22 -0.49 1.73e-21 Colorectal cancer; CRC cis rs6502050 0.835 rs12938965 chr17:80128646 G/A cg25804541 chr17:80189381 SLC16A3 -0.3 -5.84 -0.31 1.23e-8 Life satisfaction; CRC cis rs2404602 0.716 rs4079681 chr15:76695230 G/A cg03037974 chr15:76606532 NA 0.72 12.89 0.58 4.86e-31 Blood metabolite levels; CRC cis rs7666738 0.753 rs9991512 chr4:99007205 T/C cg17366294 chr4:99064904 C4orf37 0.44 7.39 0.38 1.19e-12 Colonoscopy-negative controls vs population controls; CRC cis rs7107174 1.000 rs10899492 chr11:78109810 G/A cg12700464 chr11:78128424 GAB2 -0.5 -5.91 -0.31 8.53e-9 Testicular germ cell tumor; CRC cis rs863345 0.604 rs1157524 chr1:158457298 T/C cg12129480 chr1:158549410 OR10X1 -0.29 -6.07 -0.32 3.49e-9 Pneumococcal bacteremia; CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg17429065 chr1:6453910 ACOT7 0.4 6.47 0.34 3.5e-10 Obesity-related traits; CRC cis rs921968 0.565 rs692049 chr2:219622778 G/A cg02176678 chr2:219576539 TTLL4 -0.44 -6.95 -0.36 1.93e-11 Mean corpuscular hemoglobin concentration; CRC cis rs4930103 0.590 rs3809101 chr11:1967271 C/T cg23202291 chr11:1979235 NA 0.53 7.46 0.38 7.96e-13 DNA methylation (parent-of-origin);DNA methylation (variation); CRC trans rs1656966 1.000 rs1656966 chr3:186466252 C/T cg07626433 chr4:141071632 MAML3 0.41 6.12 0.32 2.67e-9 Myopia (pathological); CRC cis rs889398 0.802 rs12921407 chr16:69860933 T/C cg00738113 chr16:70207722 CLEC18C 0.36 6.2 0.32 1.66e-9 Body mass index; CRC cis rs1915146 0.546 rs1715862 chr10:126856255 C/T cg05090351 chr10:126851162 NA -0.54 -7.82 -0.4 7.26e-14 Menarche (age at onset); CRC cis rs3858526 0.883 rs11039686 chr11:5948725 T/C cg02574844 chr11:5959923 NA -0.41 -5.82 -0.31 1.42e-8 DNA methylation (variation); CRC cis rs2739330 0.828 rs4822454 chr22:24255208 G/A cg18538332 chr22:24372958 LOC391322 -0.73 -11.89 -0.55 2.29e-27 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs881375 0.933 rs7028641 chr9:123691141 G/C cg09419670 chr9:123605666 PSMD5;LOC253039 0.57 8.46 0.42 8.8e-16 Rheumatoid arthritis; CRC cis rs853679 0.628 rs9368560 chr6:28159960 T/C cg23161317 chr6:28129485 ZNF389 0.48 6.21 0.32 1.61e-9 Depression; CRC cis rs1044826 0.642 rs4607068 chr3:139162994 A/G cg15131784 chr3:139108705 COPB2 0.41 5.93 0.31 7.87e-9 Obesity-related traits; CRC cis rs514406 0.644 rs7552663 chr1:53204352 C/T cg25767906 chr1:53392781 SCP2 0.37 5.86 0.31 1.12e-8 Monocyte count; CRC cis rs7680126 0.633 rs4698014 chr4:10286301 C/T cg11266682 chr4:10021025 SLC2A9 -0.4 -6.13 -0.32 2.51e-9 Urate levels in lean individuals;Urate levels in overweight individuals;Urate levels in obese individuals; CRC cis rs6952808 0.771 rs10244946 chr7:1921068 A/G cg00106254 chr7:1943704 MAD1L1 0.46 7.22 0.37 3.63e-12 Bipolar disorder and schizophrenia; CRC cis rs728616 0.867 rs17885031 chr10:81696091 G/A cg05935833 chr10:81318306 SFTPA2 -0.72 -8.19 -0.41 5.66e-15 Chronic obstructive pulmonary disease-related biomarkers; CRC trans rs6545883 0.965 rs7591345 chr2:61729641 T/A cg11704114 chr12:21509398 SLCO1A2 -0.33 -6.35 -0.33 7.22e-10 Tuberculosis; CRC cis rs2204008 0.744 rs11519905 chr12:38222959 G/A cg13010199 chr12:38710504 ALG10B 0.45 5.73 0.3 2.23e-8 Bladder cancer; CRC cis rs853679 0.517 rs1904841 chr6:28108085 C/T cg02631126 chr6:28058918 ZSCAN12L1 0.28 5.7 0.3 2.7e-8 Depression; CRC cis rs9649465 0.967 rs1005568 chr7:123306470 G/A cg03229431 chr7:123269106 ASB15 -0.37 -5.71 -0.3 2.56e-8 Migraine; CRC cis rs4713118 0.587 rs9393899 chr6:28133528 G/C cg06470822 chr6:28175283 NA 1.03 13.59 0.6 1.04e-33 Parkinson's disease; CRC cis rs1799949 0.930 rs1554063 chr17:41287145 T/C cg05368731 chr17:41323189 NBR1 0.63 9.57 0.47 2.58e-19 Menopause (age at onset); CRC cis rs4862750 0.874 rs6822062 chr4:187895553 T/C cg03647317 chr4:187891568 NA -0.53 -9.89 -0.48 2.27e-20 Lobe attachment (rater-scored or self-reported); CRC cis rs7618915 0.570 rs11130319 chr3:52755592 A/T cg18099408 chr3:52552593 STAB1 -0.45 -7.21 -0.37 3.91e-12 Bipolar disorder; CRC cis rs1059312 0.808 rs10847694 chr12:129292457 C/A cg23521905 chr12:129298690 SLC15A4;MGC16384 0.37 6.49 0.34 3.22e-10 Systemic lupus erythematosus; CRC cis rs1129187 0.755 rs2274517 chr6:42932715 A/G cg02359409 chr6:42947317 PEX6 0.68 11.38 0.53 1.64e-25 Alzheimer's disease in APOE e4+ carriers; CRC cis rs12188164 0.543 rs7728027 chr5:459943 T/C cg21625146 chr5:486483 SLC9A3 0.37 5.76 0.3 1.9e-8 Cystic fibrosis severity; CRC cis rs4474465 1.000 rs952605 chr11:78200427 A/T cg27205649 chr11:78285834 NARS2 -0.47 -5.79 -0.3 1.61e-8 Alzheimer's disease (survival time); CRC cis rs853679 0.550 rs9295762 chr6:28155418 C/T cg25164649 chr6:28176230 NA -0.77 -10.55 -0.5 1.27e-22 Depression; CRC cis rs11628318 0.614 rs10140498 chr14:103154191 A/G cg12046867 chr14:103022105 NA 0.65 8.07 0.41 1.29e-14 Platelet count; CRC cis rs4555082 0.718 rs2816619 chr14:105732551 G/C cg06808227 chr14:105710500 BRF1 -0.6 -8.35 -0.42 1.93e-15 Mean platelet volume;Platelet distribution width; CRC cis rs9359856 0.636 rs9344946 chr6:90298371 T/G cg13799429 chr6:90582589 CASP8AP2 0.59 7.73 0.39 1.34e-13 Bipolar disorder; CRC cis rs1691799 0.899 rs1177555 chr12:66727568 A/G cg16791601 chr12:66731901 HELB -0.68 -11.53 -0.54 4.57e-26 White blood cell count (basophil); CRC cis rs5769765 0.819 rs9616377 chr22:50310880 T/C cg22709217 chr22:50311962 ALG12;CRELD2 -1.11 -18.17 -0.71 1.37e-51 Schizophrenia; CRC cis rs10919791 0.539 rs10919786 chr1:199946176 A/G cg07208853 chr1:200005219 NR5A2 0.26 6.57 0.34 2.01e-10 Pancreatic cancer; CRC cis rs6761276 0.525 rs12711752 chr2:113837840 C/T cg09040174 chr2:113837401 NA -0.51 -7.81 -0.4 7.77e-14 Protein quantitative trait loci; CRC cis rs13256369 0.901 rs12679831 chr8:8566411 T/G cg17143192 chr8:8559678 CLDN23 0.49 6.19 0.32 1.77e-9 Obesity-related traits; CRC cis rs9926296 0.585 rs6500441 chr16:89828669 C/G cg03388025 chr16:89894329 SPIRE2 0.29 5.69 0.3 2.78e-8 Vitiligo; CRC trans rs8123881 0.733 rs7268466 chr20:15810676 C/T cg15993354 chr19:12912590 PRDX2 0.56 6.42 0.33 4.81e-10 Body mass index; CRC cis rs10927875 0.965 rs3961710 chr1:16313172 C/T cg21385522 chr1:16154831 NA -0.69 -8.71 -0.43 1.54e-16 Dilated cardiomyopathy; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg13353472 chr19:39343117 HNRNPL 0.38 6.16 0.32 2.15e-9 Liver disease severity in Alagille syndrome; CRC cis rs10751667 0.621 rs7394681 chr11:952111 C/T ch.11.42038R chr11:967971 AP2A2 0.57 9.77 0.47 5.75e-20 Alzheimer's disease (late onset); CRC trans rs916888 0.779 rs430685 chr17:44859148 T/C cg23590916 chr17:43697445 MGC57346 -0.57 -6.14 -0.32 2.32e-9 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs10791097 0.694 rs10894273 chr11:130742155 G/T cg12179176 chr11:130786555 SNX19 0.75 12.66 0.57 3.28e-30 Autism spectrum disorder or schizophrenia;Schizophrenia; CRC cis rs17095355 0.605 rs58154613 chr10:111633966 C/T cg00817464 chr10:111662876 XPNPEP1 -0.45 -5.78 -0.3 1.7e-8 Biliary atresia; CRC cis rs17767392 0.958 rs6574016 chr14:72040525 G/A cg13720639 chr14:72061746 SIPA1L1 0.56 6.88 0.35 2.96e-11 Mitral valve prolapse; CRC trans rs8002861 1.000 rs8002861 chr13:44474517 G/A cg17145862 chr1:211918768 LPGAT1 0.76 15.19 0.64 7.62e-40 Leprosy; CRC cis rs728616 0.867 rs17096197 chr10:81808184 T/C cg05935833 chr10:81318306 SFTPA2 -0.58 -6.82 -0.35 4.41e-11 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs172166 0.694 rs9295760 chr6:28147385 G/A cg02683197 chr6:28174875 NA 0.7 9.78 0.47 5.24e-20 Cardiac Troponin-T levels; CRC trans rs9467711 0.606 rs9358938 chr6:26387546 C/T cg06606381 chr12:133084897 FBRSL1 -0.81 -6.01 -0.31 5.01e-9 Autism spectrum disorder or schizophrenia; CRC cis rs7659604 0.539 rs11098648 chr4:122759872 C/T cg19748678 chr4:122722346 EXOSC9 0.66 10.51 0.5 1.82e-22 Type 2 diabetes; CRC cis rs12586317 0.547 rs28395170 chr14:35506988 C/T cg05294307 chr14:35346193 BAZ1A -0.72 -8.17 -0.41 6.66e-15 Psoriasis; CRC cis rs503341 0.756 rs480874 chr11:63591965 A/T cg04362095 chr11:63592001 C11orf84 -0.55 -8.9 -0.44 3.78e-17 Pulse pressure; CRC cis rs10256972 0.552 rs2949192 chr7:1203841 C/T cg07308232 chr7:1071921 C7orf50 -0.42 -5.76 -0.3 1.96e-8 Longevity;Endometriosis; CRC cis rs3849570 0.922 rs3772895 chr3:81769493 A/G cg07356753 chr3:81810745 GBE1 -0.74 -11.09 -0.52 1.65e-24 Waist circumference;Body mass index; CRC cis rs7552404 1.000 rs441109 chr1:76120430 T/G cg22875332 chr1:76189707 ACADM -0.68 -9.24 -0.45 3.2e-18 Blood metabolite levels;Acylcarnitine levels; CRC cis rs9640161 0.742 rs2108851 chr7:150019634 T/C cg13722127 chr7:150037890 RARRES2 0.49 7.66 0.39 2.13e-13 Blood protein levels;Circulating chemerin levels; CRC trans rs3960554 0.674 rs113848658 chr7:75791858 G/A cg19862616 chr7:65841803 NCRNA00174 0.73 8.5 0.42 6.78e-16 Eotaxin levels; CRC cis rs1018836 0.923 rs10956720 chr8:91576222 C/T cg16814680 chr8:91681699 NA -0.72 -11.87 -0.55 2.65e-27 Ejection fraction in Tripanosoma cruzi seropositivity; CRC trans rs116095464 0.558 rs10055354 chr5:243794 G/A cg00938859 chr5:1591904 SDHAP3 0.72 7.76 0.39 1.09e-13 Breast cancer; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg04190002 chr22:51113604 SHANK3 0.47 7.83 0.4 6.75e-14 Liver disease severity in Alagille syndrome; CRC cis rs10256972 0.721 rs2030959 chr7:1075906 T/C cg26608667 chr7:1196370 ZFAND2A 0.35 5.61 0.3 4.24e-8 Longevity;Endometriosis; CRC cis rs8067354 0.645 rs2645489 chr17:57883371 T/G cg13753209 chr17:57696993 CLTC 0.45 5.88 0.31 9.94e-9 Hemoglobin concentration; CRC trans rs951252 0.504 rs11734405 chr4:146081096 C/T cg06557630 chr16:49889701 NA 0.4 6.06 0.32 3.72e-9 Hip circumference; CRC cis rs9549328 0.565 rs35371379 chr13:113616715 T/C cg08614441 chr13:113633676 MCF2L 0.39 6.92 0.36 2.31e-11 Systolic blood pressure; CRC cis rs875971 0.862 rs4236208 chr7:65749078 C/T cg12463550 chr7:65579703 CRCP -0.52 -7.39 -0.38 1.23e-12 Aortic root size; CRC cis rs8038465 0.622 rs56712926 chr15:73886849 G/T cg15420318 chr15:73925796 NPTN 0.43 6.73 0.35 7.5e-11 Liver enzyme levels (gamma-glutamyl transferase); CRC trans rs1728785 1.000 rs1728792 chr16:68596534 G/C cg04657470 chr2:198365150 HSPE1;HSPD1 0.59 7.14 0.37 5.95e-12 Ulcerative colitis; CRC cis rs4665809 1.000 rs10170359 chr2:26272219 G/T cg25036284 chr2:26402008 FAM59B -0.47 -6.23 -0.32 1.45e-9 Gut microbiome composition (summer); CRC trans rs1997103 1.000 rs2140915 chr7:55410699 G/C cg20935933 chr6:143382018 AIG1 0.51 6.65 0.34 1.25e-10 QRS interval (sulfonylurea treatment interaction); CRC cis rs12200560 0.505 rs1988040 chr6:97076271 G/A cg06623918 chr6:96969491 KIAA0776 0.52 7.76 0.39 1.08e-13 Coronary heart disease; CRC cis rs3785574 0.962 rs8066463 chr17:61818390 A/G cg22520471 chr17:61851767 DDX42;CCDC47 0.44 6.13 0.32 2.55e-9 Height; CRC cis rs2580764 0.515 rs4672005 chr2:55246551 C/T cg09592903 chr2:55203963 RTN4 -0.72 -11.39 -0.53 1.49e-25 Mean platelet volume; CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg19853194 chr18:9913725 VAPA -0.53 -6.49 -0.34 3.23e-10 Diisocyanate-induced asthma; CRC cis rs853679 0.517 rs1904840 chr6:28108232 C/T cg03623178 chr6:28175578 NA 0.98 12.66 0.57 3.31e-30 Depression; CRC cis rs7953508 0.506 rs2053196 chr12:93962959 T/C cg18151635 chr12:93972918 NA -0.8 -11.67 -0.54 1.43e-26 Pubertal anthropometrics; CRC cis rs7429990 0.965 rs319692 chr3:47924317 G/C cg11946769 chr3:48343235 NME6 0.43 5.62 0.3 4.11e-8 Educational attainment (years of education); CRC cis rs172166 0.694 rs1631552 chr6:28089699 C/A cg26587870 chr6:27730563 NA -0.38 -5.73 -0.3 2.28e-8 Cardiac Troponin-T levels; CRC cis rs2630709 0.521 rs2630745 chr2:8459919 C/T cg12167548 chr2:8464763 NA 0.34 6.51 0.34 2.86e-10 Monocyte percentage of white cells; CRC cis rs853679 0.517 rs9380059 chr6:28132358 A/C cg25164649 chr6:28176230 NA 0.78 9.66 0.47 1.33e-19 Depression; CRC cis rs12134245 0.776 rs6688261 chr1:91987034 C/T cg21854759 chr1:92012499 NA -0.6 -10.68 -0.51 4.52e-23 Breast cancer; CRC cis rs6758955 1.000 rs1558629 chr2:10478364 C/T cg15773312 chr2:10472214 HPCAL1 -0.7 -9.23 -0.45 3.46e-18 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; CRC cis rs2084637 0.965 rs2370747 chr11:122407131 C/T cg21585512 chr11:122030076 LOC399959 -0.4 -7.29 -0.37 2.4e-12 Stroke; CRC cis rs2252790 0.605 rs12193974 chr6:116542500 T/C cg15226275 chr6:116381976 FRK 0.26 6.11 0.32 2.86e-9 Fast beta electroencephalogram; CRC trans rs12458462 0.892 rs2007483 chr18:77476131 A/T cg09220050 chr20:48770642 TMEM189;TMEM189-UBE2V1 -0.43 -6.14 -0.32 2.33e-9 Monocyte count; CRC cis rs654950 0.901 rs607586 chr1:42004379 C/T cg06885757 chr1:42089581 HIVEP3 -0.51 -8.11 -0.41 1.01e-14 Airway imaging phenotypes; CRC cis rs4975709 0.589 rs4975746 chr5:1861069 G/A cg15595755 chr5:1867978 NA 0.37 6.2 0.32 1.66e-9 Cardiovascular disease risk factors; CRC cis rs832540 0.552 rs702681 chr5:56218029 C/T cg18230493 chr5:56204884 C5orf35 -0.47 -6.88 -0.35 3.07e-11 Coronary artery disease; CRC cis rs9611565 0.659 rs56319767 chr22:41933837 G/A cg17554472 chr22:41940697 POLR3H -0.56 -5.89 -0.31 9.38e-9 Vitiligo; CRC cis rs798554 1.000 rs798548 chr7:2760935 A/G cg19717773 chr7:2847554 GNA12 -0.43 -6.6 -0.34 1.69e-10 Height; CRC cis rs2243480 1.000 rs34136756 chr7:65381256 A/G cg12463550 chr7:65579703 CRCP 0.65 6.22 0.32 1.49e-9 Diabetic kidney disease; CRC cis rs4924590 0.550 rs1426889 chr15:42231658 C/T cg20935245 chr15:42234343 EHD4 -0.39 -6.07 -0.32 3.51e-9 Lymphocyte percentage of white cells;Sum basophil neutrophil counts;Granulocyte count; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg11526405 chr9:131790894 SH3GLB2 0.43 6.06 0.32 3.65e-9 Response to antipsychotic treatment; CRC cis rs1153858 1.000 rs12595087 chr15:45655232 A/G cg21132104 chr15:45694354 SPATA5L1 0.6 8.86 0.44 5.02e-17 Homoarginine levels; CRC cis rs7811142 1.000 rs4472444 chr7:100070758 T/C cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.05 14.87 0.63 1.3e-38 Platelet count; CRC cis rs5753618 0.561 rs9609254 chr22:31705942 G/A cg07713946 chr22:31675144 LIMK2 0.4 5.71 0.3 2.46e-8 Colorectal cancer; CRC cis rs17095355 1.000 rs55717725 chr10:111666629 T/C cg00817464 chr10:111662876 XPNPEP1 -0.58 -7.41 -0.38 1.08e-12 Biliary atresia; CRC cis rs2204008 0.744 rs12099650 chr12:38317140 C/G cg26384229 chr12:38710491 ALG10B 0.67 9.53 0.47 3.52e-19 Bladder cancer; CRC cis rs6831352 0.918 rs34071486 chr4:100051087 A/G cg13256891 chr4:100009986 ADH5 -0.66 -8.89 -0.44 4.04e-17 Alcohol dependence; CRC cis rs11212617 0.934 rs694376 chr11:108119048 C/A cg01991180 chr11:108092276 ATM;NPAT 0.42 6.13 0.32 2.52e-9 Response to metformin in type 2 diabetes (glycemic); CRC cis rs3741404 0.594 rs11231704 chr11:63898182 C/T cg19465662 chr11:63993652 NUDT22;TRPT1 -0.59 -8.7 -0.43 1.65e-16 Platelet count; CRC cis rs7215564 0.908 rs35151535 chr17:78661695 C/T cg09596252 chr17:78655493 RPTOR 0.56 6.14 0.32 2.41e-9 Myopia (pathological); CRC cis rs7209700 0.778 rs3851807 chr17:45351519 C/G cg08085267 chr17:45401833 C17orf57 0.44 6.37 0.33 6.21e-10 IgG glycosylation; CRC cis rs2228479 1.000 rs62052186 chr16:89969567 A/T cg19635926 chr16:89946313 TCF25 0.61 5.81 0.31 1.44e-8 Skin colour saturation; CRC cis rs270601 0.690 rs162904 chr5:131595784 C/T cg02033258 chr5:131593261 PDLIM4 -0.45 -7.92 -0.4 3.69e-14 Acylcarnitine levels; CRC cis rs1113500 0.932 rs1343205 chr1:108597873 C/G cg06207961 chr1:108661230 NA 0.4 5.8 0.3 1.57e-8 Growth-regulated protein alpha levels; CRC cis rs35306767 0.953 rs11253517 chr10:970524 A/G cg26597838 chr10:835615 NA -0.81 -9.94 -0.48 1.61e-20 Eosinophil percentage of granulocytes; CRC cis rs66573146 1.000 rs6812391 chr4:6963893 G/A cg00086871 chr4:6988644 TBC1D14 0.96 7.03 0.36 1.2e-11 Granulocyte percentage of myeloid white cells; CRC cis rs12024301 0.557 rs12040874 chr1:183615776 G/A cg11505048 chr1:183622726 RGL1;APOBEC4 0.81 7.0 0.36 1.42e-11 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs924607 1.000 rs12523022 chr5:598643 C/T cg04476341 chr5:669733 TPPP -0.42 -6.91 -0.36 2.45e-11 Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia; CRC cis rs2153535 0.504 rs4493781 chr6:8473941 G/C cg21535247 chr6:8435926 SLC35B3 0.51 7.71 0.39 1.54e-13 Motion sickness; CRC cis rs2404602 0.532 rs206205 chr15:76736091 T/G cg23625390 chr15:77176239 SCAPER 0.58 9.02 0.45 1.59e-17 Blood metabolite levels; CRC trans rs2303319 0.504 rs62189041 chr2:162599506 T/C cg11326919 chr17:43324904 LOC100133991 -0.64 -5.97 -0.31 5.99e-9 Cognitive function; CRC cis rs832540 1.000 rs252914 chr5:56198150 A/C cg24531977 chr5:56204891 C5orf35 -0.44 -6.68 -0.35 1e-10 Coronary artery disease; CRC cis rs12540874 0.698 rs13234331 chr7:50560314 G/T cg14593290 chr7:50529359 DDC -0.5 -7.15 -0.37 5.52e-12 Systemic sclerosis; CRC cis rs9398803 0.931 rs1361262 chr6:126701967 T/C cg19875578 chr6:126661172 C6orf173 0.41 5.68 0.3 2.98e-8 Male-pattern baldness; CRC cis rs1580019 0.563 rs896137 chr7:32579345 G/T cg06627557 chr7:32535165 LSM5;AVL9 0.98 18.55 0.71 4.45e-53 Cognitive ability; CRC cis rs1552244 1.000 rs112509186 chr3:10156533 A/G cg02579736 chr3:10068473 FANCD2;CIDECP 1.03 13.46 0.6 3.42e-33 Alzheimer's disease; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg15726318 chr8:71315757 NCOA2 0.34 6.11 0.32 2.78e-9 Liver disease severity in Alagille syndrome; CRC trans rs9952051 0.961 rs12717053 chr18:63264766 C/T cg20240715 chr21:35828503 KCNE1 0.33 6.11 0.32 2.85e-9 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; CRC cis rs1552244 0.938 rs7625049 chr3:10115619 C/T cg10729496 chr3:10149963 C3orf24 0.5 6.78 0.35 5.69e-11 Alzheimer's disease; CRC cis rs4481887 0.893 rs28787378 chr1:248504447 C/T cg00666640 chr1:248458726 OR2T12 0.5 9.33 0.46 1.65e-18 Common traits (Other); CRC trans rs11039798 1.000 rs7131020 chr11:48642132 A/G cg03929089 chr4:120376271 NA 0.63 6.1 0.32 3.03e-9 Axial length; CRC cis rs8180040 0.764 rs4682852 chr3:47177772 C/T cg10298567 chr3:47292165 KIF9 -0.38 -6.23 -0.32 1.44e-9 Colorectal cancer; CRC cis rs9517313 0.554 rs3809366 chr13:99230266 C/T cg20487152 chr13:99095054 FARP1 -0.45 -6.43 -0.33 4.56e-10 Neuroticism; CRC cis rs4319547 0.698 rs10773178 chr12:122944752 T/C cg05707623 chr12:122985044 ZCCHC8 -0.54 -7.15 -0.37 5.79e-12 Body mass index; CRC cis rs10256972 0.577 rs4999286 chr7:1199506 C/G cg16145915 chr7:1198662 ZFAND2A -0.51 -10.59 -0.5 9.28e-23 Longevity;Endometriosis; CRC cis rs6952808 0.608 rs6461049 chr7:2017445 C/T cg22963979 chr7:1858916 MAD1L1 0.42 6.6 0.34 1.65e-10 Bipolar disorder and schizophrenia; CRC cis rs6582630 0.502 rs7311700 chr12:38463232 T/A cg26384229 chr12:38710491 ALG10B 0.71 9.5 0.46 4.39e-19 Drug-induced liver injury (flucloxacillin); CRC cis rs4664293 0.715 rs13002625 chr2:160504625 T/C cg08347373 chr2:160653686 CD302 0.45 7.79 0.39 8.83e-14 Monocyte percentage of white cells; CRC cis rs6662572 1.000 rs41310432 chr1:46083706 C/G cg03123370 chr1:45965343 CCDC163P;MMACHC 0.48 5.68 0.3 3.02e-8 Blood protein levels; CRC cis rs9467711 0.538 rs7766531 chr6:25886577 T/C cg08501292 chr6:25962987 TRIM38 0.98 9.07 0.45 1.09e-17 Autism spectrum disorder or schizophrenia; CRC cis rs172166 0.516 rs1150670 chr6:28130559 A/G cg15845792 chr6:28175446 NA 0.64 9.63 0.47 1.66e-19 Cardiac Troponin-T levels; CRC cis rs4665809 0.525 rs4665324 chr2:26447147 A/C cg04944784 chr2:26401820 FAM59B -0.85 -11.05 -0.52 2.29e-24 Gut microbiome composition (summer); CRC cis rs3749237 0.595 rs1050088 chr3:49570882 C/T cg03060546 chr3:49711283 APEH -0.69 -11.86 -0.55 3.08e-27 Resting heart rate; CRC cis rs1865760 0.613 rs7749342 chr6:25920265 T/C cg12310025 chr6:25882481 NA -0.44 -6.57 -0.34 1.95e-10 Height; CRC cis rs11229555 0.598 rs12289876 chr11:58185250 C/T cg15696309 chr11:58395628 NA -0.81 -10.31 -0.49 8.83e-22 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; CRC cis rs11167764 1.000 rs3761757 chr5:141488219 A/C cg08523384 chr5:141488047 NDFIP1 -0.5 -8.49 -0.42 7.34e-16 Crohn's disease; CRC cis rs4363385 0.818 rs946095 chr1:153006470 T/C cg25856811 chr1:152973957 SPRR3 -0.25 -6.99 -0.36 1.51e-11 Inflammatory skin disease; CRC trans rs9526114 1.000 rs12430490 chr13:46411812 A/G cg18557684 chr14:22362441 NA 0.39 5.97 0.31 6.2e-9 Pneumococcal bacteremia; CRC cis rs919433 0.963 rs10166569 chr2:198183439 G/A cg20885578 chr2:198174922 NA -0.42 -6.69 -0.35 9.64e-11 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC cis rs1572438 0.760 rs7766714 chr6:869519 C/T cg21062780 chr6:887772 NA -0.38 -5.98 -0.31 5.78e-9 Aging; CRC cis rs873946 0.564 rs12263364 chr10:134555548 G/T cg27286337 chr10:134555280 INPP5A 0.74 9.61 0.47 1.9e-19 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CRC trans rs57221529 0.766 rs56278696 chr5:582669 A/G cg25482853 chr8:67687455 SGK3 1.24 14.83 0.63 1.93e-38 Lung disease severity in cystic fibrosis; CRC cis rs1419980 0.673 rs10772553 chr12:7768089 G/A cg10578777 chr12:7781093 NA -0.45 -6.08 -0.32 3.41e-9 HDL cholesterol levels; CRC cis rs2276314 0.553 rs12964535 chr18:33611691 A/C cg05985134 chr18:33552581 C18orf21 -0.37 -5.86 -0.31 1.1e-8 Endometriosis;Drug-induced torsades de pointes; CRC cis rs4927850 0.709 rs6765762 chr3:195652851 G/A cg23245007 chr3:195682326 NA -0.4 -5.63 -0.3 3.81e-8 Pancreatic cancer; CRC cis rs17270561 0.583 rs7765833 chr6:25712433 C/A cg16482183 chr6:26056742 HIST1H1C 0.67 8.6 0.43 3.39e-16 Iron status biomarkers; CRC cis rs4713675 0.546 rs10947435 chr6:33718075 G/A cg14003231 chr6:33640908 ITPR3 0.45 7.24 0.37 3.22e-12 Plateletcrit; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg13197406 chr4:57687839 SPINK2 0.33 6.08 0.32 3.33e-9 Liver disease severity in Alagille syndrome; CRC cis rs9807989 0.765 rs6751977 chr2:102967430 T/C cg03938978 chr2:103052716 IL18RAP 0.37 5.97 0.31 6.2e-9 Asthma; CRC cis rs6762477 0.748 rs11711407 chr3:50225029 A/G cg05623727 chr3:50126028 RBM5 -0.39 -6.6 -0.34 1.67e-10 Menarche (age at onset); CRC cis rs9527 0.590 rs3861984 chr10:104916980 T/C cg04362960 chr10:104952993 NT5C2 0.6 8.33 0.42 2.16e-15 Arsenic metabolism; CRC cis rs853679 0.517 rs1947862 chr6:28105196 C/T cg15786705 chr6:28176104 NA 0.77 9.78 0.47 5.51e-20 Depression; CRC cis rs1003719 0.591 rs13046303 chr21:38551976 A/G cg10648535 chr21:38446584 PIGP;TTC3 -0.45 -6.39 -0.33 5.67e-10 Eye color traits; CRC cis rs9467603 0.547 rs913455 chr6:25420344 C/G cg16898833 chr6:26189333 HIST1H4D -0.77 -5.86 -0.31 1.15e-8 Intelligence (multi-trait analysis); CRC cis rs651907 0.557 rs11917569 chr3:101355063 G/C cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.64 8.62 0.43 2.86e-16 Colorectal cancer; CRC cis rs1832871 0.521 rs62437409 chr6:158820221 G/C cg07165851 chr6:158734300 TULP4 0.45 5.83 0.31 1.3e-8 Height; CRC cis rs10512697 0.803 rs35056798 chr5:3575747 A/G cg19473799 chr5:3511975 NA -0.72 -5.67 -0.3 3.12e-8 Immune response to smallpox vaccine (IL-6); CRC cis rs763121 0.819 rs4560233 chr22:38982442 A/T cg06544989 chr22:39130855 UNC84B 0.42 6.35 0.33 7.13e-10 Menopause (age at onset); CRC trans rs9467711 0.606 rs2072803 chr6:26392515 G/C cg06606381 chr12:133084897 FBRSL1 -0.81 -6.05 -0.32 3.91e-9 Autism spectrum disorder or schizophrenia; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg03956833 chr1:1051711 C1orf159 0.51 7.23 0.37 3.38e-12 Response to antipsychotic treatment; CRC cis rs7089973 0.604 rs7920216 chr10:116611794 G/A cg23260525 chr10:116636907 FAM160B1 0.35 8.05 0.41 1.49e-14 Bipolar disorder or attention deficit hyperactivity disorder; CRC cis rs561341 0.769 rs12941700 chr17:30185022 A/G cg12193833 chr17:30244370 NA 0.57 6.54 0.34 2.39e-10 Hip circumference adjusted for BMI; CRC cis rs1190596 0.525 rs6575901 chr14:102691854 A/G cg18135206 chr14:102964638 TECPR2 0.41 5.64 0.3 3.7e-8 Behavioural disinhibition (generation interaction); CRC cis rs17539620 0.624 rs7770107 chr6:154836862 A/G cg20019720 chr6:154832845 CNKSR3 0.5 8.15 0.41 7.48e-15 Lipoprotein (a) levels; CRC cis rs10256972 0.567 rs7782651 chr7:1159895 T/G cg16145915 chr7:1198662 ZFAND2A -0.43 -8.2 -0.41 5.37e-15 Longevity;Endometriosis; CRC cis rs10256972 0.567 rs2949185 chr7:1209013 A/G cg04025307 chr7:1156635 C7orf50 0.68 10.79 0.51 2e-23 Longevity;Endometriosis; CRC cis rs7591163 1.000 rs6744308 chr2:228711816 T/G cg00063174 chr2:228736253 WDR69 -0.51 -6.86 -0.35 3.49e-11 Blood pressure; CRC cis rs912057 0.671 rs1294433 chr6:6745163 G/A cg06612196 chr6:6737390 NA 0.51 8.04 0.41 1.62e-14 Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg18411480 chr20:2082418 STK35 0.38 6.05 0.32 3.99e-9 Liver disease severity in Alagille syndrome; CRC cis rs72781680 0.821 rs72790304 chr2:24108557 G/A cg08917208 chr2:24149416 ATAD2B 0.58 6.89 0.36 2.87e-11 Lymphocyte counts; CRC cis rs2836950 0.565 rs2836934 chr21:40564885 A/C cg11644478 chr21:40555479 PSMG1 -0.48 -7.07 -0.36 9.63e-12 Menarche (age at onset); CRC cis rs4666002 0.917 rs2068834 chr2:27839539 A/G cg27432699 chr2:27873401 GPN1 0.43 5.71 0.3 2.48e-8 Phospholipid levels (plasma); CRC cis rs4862750 0.914 rs9998558 chr4:187874691 A/G cg27532560 chr4:187881888 NA -0.54 -9.81 -0.48 4.32e-20 Lobe attachment (rater-scored or self-reported); CRC cis rs6920965 0.507 rs4285341 chr6:126205589 T/G cg05901451 chr6:126070800 HEY2 -0.41 -6.08 -0.32 3.28e-9 High light scatter reticulocyte count; CRC cis rs13191362 1.000 rs35044651 chr6:163004142 G/A cg21926612 chr6:163149169 PACRG;PARK2 0.8 11.13 0.52 1.19e-24 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg00102714 chr1:207925343 CD46 0.42 6.74 0.35 7.32e-11 Liver disease severity in Alagille syndrome; CRC cis rs2839186 0.732 rs8131458 chr21:47694712 G/A cg00612595 chr21:47717864 NA -0.37 -6.15 -0.32 2.22e-9 Testicular germ cell tumor; CRC cis rs801193 1.000 rs7788576 chr7:66148302 G/A cg00343986 chr7:65444356 GUSB -0.49 -7.24 -0.37 3.15e-12 Aortic root size; CRC cis rs8177253 0.761 rs1830084 chr3:133508464 A/T cg08048268 chr3:133502702 NA 0.47 9.03 0.45 1.53e-17 Iron status biomarkers; CRC cis rs7223966 1.000 rs11658175 chr17:61923838 G/A cg05941027 chr17:61774174 LIMD2 0.34 6.0 0.31 5.21e-9 Hip circumference adjusted for BMI;Body mass index; CRC cis rs9556958 0.708 rs4772092 chr13:99166614 A/G cg15168958 chr13:99100528 FARP1 0.39 6.41 0.33 4.9e-10 Educational attainment (years of education); CRC cis rs4862750 0.957 rs2375916 chr4:187903923 A/G cg27532560 chr4:187881888 NA -0.59 -10.52 -0.5 1.71e-22 Lobe attachment (rater-scored or self-reported); CRC cis rs2303745 0.589 rs6512182 chr19:17399476 G/T cg04248312 chr19:17393744 ANKLE1 -0.97 -14.43 -0.62 6.3e-37 Systemic lupus erythematosus; CRC cis rs801193 0.569 rs7782587 chr7:66166472 C/T cg00343986 chr7:65444356 GUSB 0.43 5.97 0.31 6.08e-9 Aortic root size; CRC cis rs9595066 0.715 rs9567366 chr13:44682973 A/C cg04068111 chr13:44716778 NA 0.39 5.63 0.3 3.78e-8 Schizophrenia; CRC cis rs644799 0.710 rs10831433 chr11:95519787 C/T cg03916912 chr11:95522834 CEP57;FAM76B 0.87 16.07 0.66 2.59e-43 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs3096299 0.719 rs2911262 chr16:89515041 C/T cg02187348 chr16:89574699 SPG7 0.41 6.01 0.31 5.04e-9 Multiple myeloma (IgH translocation); CRC cis rs12541635 0.677 rs1817939 chr8:107029820 A/G cg10147462 chr8:107024639 NA 0.6 10.9 0.52 7.96e-24 Age of smoking initiation; CRC cis rs17152411 1.000 rs12355869 chr10:126645231 G/T cg07906193 chr10:126599966 NA 0.63 6.92 0.36 2.34e-11 Height; CRC cis rs4930103 0.619 rs739905 chr11:1980360 G/C cg23202291 chr11:1979235 NA 0.63 9.43 0.46 7.35e-19 DNA methylation (parent-of-origin);DNA methylation (variation); CRC cis rs4975616 0.710 rs27996 chr5:1345474 A/G cg26373071 chr5:1325741 CLPTM1L 0.48 8.42 0.42 1.17e-15 Lung cancer; CRC cis rs78456975 1.000 rs72776298 chr2:1570163 C/G cg12573674 chr2:1569213 NA -0.76 -8.04 -0.41 1.69e-14 Placebo response in major depressive disorder (% change in symptom score); CRC cis rs2361718 0.522 rs11867921 chr17:78121170 G/T cg25050447 chr17:78165522 CARD14 0.42 5.79 0.3 1.69e-8 Yeast infection; CRC cis rs6088590 1.000 rs6087632 chr20:33407704 A/C cg08999081 chr20:33150536 PIGU 0.5 8.65 0.43 2.28e-16 Coronary artery disease; CRC cis rs4713118 0.539 rs200951 chr6:27835930 A/G cg12273811 chr6:28175739 NA 0.54 7.55 0.38 4.19e-13 Parkinson's disease; CRC cis rs10504229 0.679 rs56040464 chr8:58131603 G/A cg04204079 chr8:58130323 NA -0.45 -5.78 -0.3 1.71e-8 Developmental language disorder (linguistic errors); CRC cis rs9660992 0.547 rs748012 chr1:205216573 C/T cg00857998 chr1:205179979 DSTYK 0.44 5.75 0.3 2.03e-8 Mean corpuscular volume;Mean platelet volume; CRC cis rs7113874 0.569 rs2289921 chr11:8496611 G/C cg17679104 chr11:8615758 STK33 0.34 5.66 0.3 3.28e-8 Body mass index in physically active individuals;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs9470366 0.816 rs7774130 chr6:36623756 C/T cg08179530 chr6:36648295 CDKN1A 0.51 6.02 0.32 4.55e-9 QRS duration; CRC cis rs9462027 0.583 rs9469902 chr6:34793768 G/A cg07306190 chr6:34760872 UHRF1BP1 -0.35 -6.15 -0.32 2.28e-9 Systemic lupus erythematosus; CRC cis rs7932354 0.554 rs6485721 chr11:47040854 A/G cg03339077 chr11:47165057 C11orf49 0.44 6.18 0.32 1.91e-9 Bone mineral density (hip);Bone mineral density; CRC cis rs7727544 0.636 rs2631365 chr5:131705949 T/C cg07395648 chr5:131743802 NA 0.41 6.43 0.33 4.42e-10 Blood metabolite levels; CRC cis rs9372498 0.536 rs62422229 chr6:118959288 T/C cg10217327 chr6:118973057 C6orf204 0.51 5.66 0.3 3.27e-8 Diastolic blood pressure; CRC cis rs2072499 0.966 rs2842865 chr1:156159532 G/A cg06970220 chr1:156163860 SLC25A44 0.5 7.13 0.37 6.42e-12 Testicular germ cell tumor; CRC trans rs1814175 0.765 rs1794141 chr11:49914135 G/C cg03929089 chr4:120376271 NA -0.98 -19.27 -0.73 6.62e-56 Height; CRC trans rs783540 0.967 rs783527 chr15:83285847 C/T cg18393722 chr15:85113863 UBE2QP1 -0.37 -6.15 -0.32 2.21e-9 Schizophrenia; CRC cis rs11123610 0.520 rs59726279 chr2:3718655 A/G cg10645314 chr2:3704589 ALLC -0.55 -6.45 -0.34 4.02e-10 Response to inhaled corticosteroid treatment in asthma (change in FEV1); CRC cis rs8114671 0.628 rs6060130 chr20:33549319 C/T cg07148914 chr20:33460835 GGT7 0.38 6.01 0.31 4.92e-9 Height; CRC cis rs875971 0.545 rs7783889 chr7:65748353 T/A cg05627663 chr7:65219948 SNORA22;CCT6P1 0.57 7.47 0.38 7.35e-13 Aortic root size; CRC trans rs916888 0.647 rs199523 chr17:44848517 C/A cg22968622 chr17:43663579 NA -0.8 -10.59 -0.5 9.88e-23 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs5750830 0.649 rs5750813 chr22:39795228 G/C cg05872129 chr22:39784769 NA -0.59 -10.78 -0.51 2.13e-23 Intelligence (multi-trait analysis); CRC cis rs853679 0.517 rs4713150 chr6:28136212 G/A cg21251018 chr6:28226885 NKAPL 0.48 6.12 0.32 2.68e-9 Depression; CRC cis rs7666738 0.830 rs7659006 chr4:98934529 T/C cg17366294 chr4:99064904 C4orf37 0.43 7.32 0.37 1.95e-12 Colonoscopy-negative controls vs population controls; CRC cis rs7044106 0.791 rs4837793 chr9:123483621 G/A cg09586646 chr9:123605570 PSMD5;LOC253039 0.68 10.09 0.49 4.96e-21 Hip circumference adjusted for BMI; CRC cis rs8044868 0.530 rs12918956 chr16:72224335 A/G cg23815491 chr16:72088622 HP -0.42 -6.44 -0.33 4.2e-10 Body mass index (change over time) in cancer or chronic obstructive pulmonary disease;Body mass index (change over time) in cancer; CRC cis rs9311474 0.652 rs411457 chr3:52228150 A/T cg08222913 chr3:52553049 STAB1 0.33 6.26 0.33 1.22e-9 Electroencephalogram traits; CRC cis rs9747201 0.894 rs4503854 chr17:80178696 A/T cg14673194 chr17:80132900 CCDC57 -0.46 -5.86 -0.31 1.12e-8 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs9486719 0.857 rs4486027 chr6:96911886 T/C cg06623918 chr6:96969491 KIAA0776 -0.82 -11.68 -0.54 1.36e-26 Migraine;Coronary artery disease; CRC cis rs743757 0.878 rs1467914 chr3:50523668 A/G cg08207895 chr3:50388901 TUSC4;CYB561D2 0.46 6.3 0.33 9.78e-10 Diastolic blood pressure; CRC cis rs6502050 0.799 rs6416859 chr17:80111442 G/C cg13198984 chr17:80129470 CCDC57 0.46 8.16 0.41 6.94e-15 Life satisfaction; CRC trans rs208520 1.000 rs12190187 chr6:66973207 T/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.89 10.97 0.52 4.54e-24 Exhaled nitric oxide output; CRC cis rs4924590 0.531 rs12913835 chr15:42227869 C/T cg20935245 chr15:42234343 EHD4 0.36 5.72 0.3 2.36e-8 Lymphocyte percentage of white cells;Sum basophil neutrophil counts;Granulocyte count; CRC cis rs7618915 0.571 rs2251219 chr3:52584787 C/T cg15147215 chr3:52552868 STAB1 0.63 10.36 0.5 6.06e-22 Bipolar disorder; CRC cis rs2274273 0.905 rs8007944 chr14:55576816 A/C cg23234261 chr14:55582407 NA -0.29 -5.65 -0.3 3.53e-8 Protein biomarker; CRC cis rs2760061 0.819 rs1745416 chr1:228204497 G/A cg02753203 chr1:228287806 NA 0.68 10.55 0.5 1.34e-22 Diastolic blood pressure; CRC cis rs2976388 0.566 rs2585146 chr8:143798641 A/C cg10596483 chr8:143751796 JRK 0.46 6.31 0.33 8.88e-10 Urinary tract infection frequency; CRC cis rs4555082 0.834 rs2735816 chr14:105721603 C/G cg13114125 chr14:105738426 BRF1 0.79 11.87 0.55 2.65e-27 Mean platelet volume;Platelet distribution width; CRC cis rs6952808 0.689 rs4719391 chr7:2048136 T/C cg18279126 chr7:2041391 MAD1L1 0.44 6.68 0.35 1.04e-10 Bipolar disorder and schizophrenia; CRC trans rs2727020 0.656 rs7925524 chr11:49437542 G/A cg15704280 chr7:45808275 SEPT13 -0.79 -11.1 -0.52 1.56e-24 Coronary artery disease; CRC cis rs9287719 0.967 rs4669599 chr2:10758029 T/C cg00105475 chr2:10696890 NA 0.44 7.14 0.37 6.13e-12 Prostate cancer; CRC cis rs7481584 0.624 rs413368 chr11:3047646 C/G cg25174290 chr11:3078921 CARS -0.41 -5.71 -0.3 2.56e-8 Calcium levels; CRC cis rs6860806 0.661 rs4705929 chr5:131584178 G/T cg18758796 chr5:131593413 PDLIM4 0.44 8.12 0.41 9.72e-15 Breast cancer; CRC cis rs6088590 1.000 rs1998028 chr20:33344595 A/T cg24642439 chr20:33292090 TP53INP2 0.6 10.84 0.51 1.33e-23 Coronary artery disease; CRC cis rs17767392 0.881 rs9672060 chr14:72010126 G/T cg13720639 chr14:72061746 SIPA1L1 -0.55 -7.17 -0.37 4.95e-12 Mitral valve prolapse; CRC cis rs734999 0.870 rs2147905 chr1:2482921 C/T cg18854424 chr1:2615690 NA -0.42 -7.51 -0.38 5.75e-13 Ulcerative colitis; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg06443542 chr10:100206752 HPS1 -0.41 -6.05 -0.32 3.95e-9 Myopia (pathological); CRC trans rs2303319 0.504 rs12470590 chr2:162493102 A/G cg07195197 chr16:1662150 IFT140 -0.7 -5.98 -0.31 5.91e-9 Cognitive function; CRC cis rs28386778 0.830 rs2597636 chr17:61876010 A/G cg23090583 chr17:61904693 PSMC5;FTSJ3 1.05 20.15 0.74 2.13e-59 Prudent dietary pattern; CRC cis rs250677 0.652 rs250680 chr5:148436024 T/C cg23229984 chr5:148520753 ABLIM3 0.48 6.59 0.34 1.79e-10 Breast cancer; CRC cis rs17739167 0.569 rs11638621 chr15:42228226 C/T cg20935245 chr15:42234343 EHD4 0.42 6.5 0.34 2.95e-10 Monocyte count; CRC cis rs12594515 1.000 rs8032361 chr15:45988553 T/C cg22117107 chr15:45993392 NA -0.44 -9.09 -0.45 9.56e-18 Waist circumference;Weight; CRC cis rs1552244 0.938 rs7647987 chr3:10140696 A/G cg16606324 chr3:10149918 C3orf24 0.69 9.75 0.47 6.97e-20 Alzheimer's disease; CRC cis rs8105895 0.867 rs12151358 chr19:22282608 G/A cg02912127 chr19:22235281 ZNF257 -0.41 -5.7 -0.3 2.62e-8 Body mass index (change over time); CRC cis rs7725052 0.609 rs4957292 chr5:40446223 A/C cg09067459 chr5:40385259 NA -0.39 -6.57 -0.34 1.96e-10 Pediatric autoimmune diseases; CRC cis rs9372498 0.536 rs7356947 chr6:118767920 A/G cg18833306 chr6:118973337 C6orf204 0.44 5.81 0.31 1.48e-8 Diastolic blood pressure; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg08983011 chr11:118774009 BCL9L 0.42 6.45 0.34 3.92e-10 Response to antipsychotic treatment; CRC cis rs8060686 0.641 rs1125331 chr16:68228119 T/C cg26727032 chr16:67993705 SLC12A4 -0.52 -6.71 -0.35 8.5e-11 HDL cholesterol;Metabolic syndrome; CRC cis rs68170813 0.559 rs17429146 chr7:106964281 A/G cg02696742 chr7:106810147 HBP1 -0.58 -6.38 -0.33 5.85e-10 Coronary artery disease; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg14706950 chr10:93169801 HECTD2;LOC100188947 0.45 6.14 0.32 2.35e-9 Anxiety disorder; CRC cis rs6835098 0.924 rs2332669 chr4:174163398 G/A cg08422745 chr4:174089978 GALNT7 -0.86 -13.63 -0.6 7.74e-34 Dementia and core Alzheimer's disease neuropathologic changes; CRC cis rs6570726 0.791 rs436156 chr6:145874873 A/G cg23711669 chr6:146136114 FBXO30 0.77 13.41 0.59 5.06e-33 Lobe attachment (rater-scored or self-reported); CRC cis rs1707322 1.000 rs785486 chr1:46575148 G/C cg03146154 chr1:46216737 IPP -0.52 -7.15 -0.37 5.72e-12 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs4689592 0.503 rs10516184 chr4:7060959 C/T cg19539972 chr4:7069911 GRPEL1 0.82 9.3 0.46 2.08e-18 Monocyte percentage of white cells; CRC cis rs1153858 1.000 rs4775909 chr15:45643042 T/C cg21132104 chr15:45694354 SPATA5L1 0.57 8.52 0.43 5.89e-16 Homoarginine levels; CRC cis rs6582630 0.547 rs1589388 chr12:38416025 C/T cg13010199 chr12:38710504 ALG10B -0.4 -5.62 -0.3 3.99e-8 Drug-induced liver injury (flucloxacillin); CRC cis rs62064224 0.589 rs9904964 chr17:30662832 A/G cg18200150 chr17:30822561 MYO1D -0.44 -8.54 -0.43 5e-16 Schizophrenia; CRC cis rs10504229 0.953 rs66676208 chr8:58173866 C/T cg02290350 chr8:58132656 NA -0.42 -5.96 -0.31 6.62e-9 Developmental language disorder (linguistic errors); CRC cis rs2354432 0.607 rs3766524 chr1:146729093 A/G cg25205988 chr1:146714368 CHD1L -1.17 -9.73 -0.47 7.81e-20 Mitochondrial DNA levels; CRC cis rs11168351 0.926 rs10875719 chr12:48411158 T/C cg21466736 chr12:48725269 NA -0.49 -7.57 -0.39 3.74e-13 Bipolar disorder and schizophrenia; CRC cis rs941873 0.803 rs2105461 chr10:81101679 A/G cg09469691 chr10:81107165 PPIF -0.52 -8.3 -0.42 2.79e-15 Height; CRC cis rs3736485 0.873 rs10851502 chr15:51890936 A/G cg08986416 chr15:51914746 DMXL2 -0.47 -6.55 -0.34 2.22e-10 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs72634258 0.554 rs7556518 chr1:7847846 G/A cg26816564 chr1:7831052 VAMP3 0.81 9.42 0.46 7.93e-19 Inflammatory bowel disease; CRC cis rs4820294 1.000 rs62236668 chr22:38063870 G/A cg21798802 chr22:38057573 PDXP 0.47 7.7 0.39 1.63e-13 Fat distribution (HIV); CRC cis rs7727544 0.548 rs4705938 chr5:131694077 A/G cg09877947 chr5:131593287 PDLIM4 0.33 5.89 0.31 9.42e-9 Blood metabolite levels; CRC cis rs7811142 0.830 rs10085549 chr7:99983135 C/T cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.03 14.54 0.63 2.38e-37 Platelet count; CRC cis rs9381040 0.626 rs2272986 chr6:41037778 C/T cg09580153 chr6:41068724 NFYA;LOC221442 -0.44 -6.41 -0.33 4.97e-10 Alzheimer's disease (late onset); CRC cis rs9287719 0.935 rs61424402 chr2:10758371 T/A cg00105475 chr2:10696890 NA 0.44 7.08 0.36 8.73e-12 Prostate cancer; CRC cis rs2481665 0.765 rs2481679 chr1:62634303 T/A cg18591186 chr1:62594603 INADL -0.49 -6.84 -0.35 3.79e-11 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs4332037 0.539 rs55790766 chr7:2021248 C/T cg24505167 chr7:1915268 MAD1L1 -0.45 -6.32 -0.33 8.39e-10 Bipolar disorder; CRC cis rs6893807 0.778 rs1501672 chr5:87963761 A/G cg09002922 chr5:87956389 LOC645323 -0.44 -5.66 -0.3 3.23e-8 Body mass index; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg08611430 chr5:137801033 EGR1 0.48 6.24 0.33 1.35e-9 Anxiety disorder; CRC cis rs1153858 1.000 rs67461176 chr15:45676819 C/T cg10760299 chr15:45669010 GATM 0.49 7.65 0.39 2.19e-13 Homoarginine levels; CRC cis rs10504073 0.669 rs341801 chr8:50037784 A/G cg00325661 chr8:49890786 NA 0.46 8.23 0.41 4.37e-15 Blood metabolite ratios; CRC cis rs2836974 0.644 rs7281853 chr21:40693490 A/G cg06238570 chr21:40685208 BRWD1 -0.81 -12.26 -0.56 1.01e-28 Cognitive function; CRC cis rs2479724 0.818 rs9357369 chr6:41818202 A/C cg17623882 chr6:41773611 USP49 -0.57 -9.79 -0.48 4.84e-20 Menarche (age at onset); CRC cis rs4664308 0.935 rs4665148 chr2:160917901 A/G cg03641300 chr2:160917029 PLA2R1 -0.75 -12.15 -0.56 2.56e-28 Idiopathic membranous nephropathy; CRC trans rs1147246 0.714 rs323848 chr12:125878240 G/A cg23470196 chr14:102695671 RAGE 0.41 5.98 0.31 5.73e-9 Amyotrophic lateral sclerosis (sporadic); CRC cis rs734999 0.545 rs6698817 chr1:2564183 T/C cg18854424 chr1:2615690 NA -0.4 -7.52 -0.38 5.37e-13 Ulcerative colitis; CRC cis rs2845885 0.793 rs56241103 chr11:63882364 C/T cg05555928 chr11:63887634 MACROD1 -0.54 -6.42 -0.33 4.89e-10 Body mass index; CRC cis rs2777491 0.915 rs28578057 chr15:41621921 G/A cg18705301 chr15:41695430 NDUFAF1 -0.69 -11.44 -0.53 9.35e-26 Ulcerative colitis; CRC cis rs10256972 0.577 rs6962809 chr7:1208889 A/G cg03923535 chr7:1197113 ZFAND2A 0.74 11.1 0.52 1.6e-24 Longevity;Endometriosis; CRC cis rs9381040 0.655 rs879491 chr6:41026953 A/G cg03644281 chr6:41068752 NFYA;LOC221442 -0.45 -6.48 -0.34 3.25e-10 Alzheimer's disease (late onset); CRC cis rs9926296 0.682 rs467357 chr16:89717397 A/G cg03605463 chr16:89740564 NA 0.58 8.87 0.44 4.65e-17 Vitiligo; CRC cis rs6840360 0.642 rs2709834 chr4:152375424 T/G cg09659197 chr4:152720779 NA 0.33 6.46 0.34 3.69e-10 Intelligence (multi-trait analysis); CRC cis rs9549328 0.700 rs34890317 chr13:113617245 G/C cg25790453 chr13:113633590 MCF2L 0.44 7.62 0.39 2.75e-13 Systolic blood pressure; CRC cis rs995000 0.931 rs746735 chr1:63113511 C/A cg19896129 chr1:63156450 NA -0.41 -6.34 -0.33 7.66e-10 Triglyceride levels; CRC cis rs3789045 0.774 rs898388 chr1:204500257 C/T cg17419461 chr1:204415978 PIK3C2B -0.54 -7.56 -0.38 4.14e-13 Educational attainment (college completion); CRC cis rs1799949 0.930 rs35292991 chr17:41334016 C/A cg05368731 chr17:41323189 NBR1 0.67 10.02 0.48 8.75e-21 Menopause (age at onset); CRC cis rs9611565 0.921 rs2143695 chr22:41728620 A/G cg06634786 chr22:41940651 POLR3H -0.44 -5.88 -0.31 1e-8 Vitiligo; CRC cis rs921968 0.643 rs585859 chr2:219383121 C/T cg02176678 chr2:219576539 TTLL4 0.48 7.92 0.4 3.59e-14 Mean corpuscular hemoglobin concentration; CRC cis rs8103278 1.000 rs9807819 chr19:46239598 C/T cg14061069 chr19:46274453 DMPK -0.61 -9.48 -0.46 5.18e-19 Coronary artery disease; CRC cis rs739401 0.611 rs2239899 chr11:3024624 A/G cg05729581 chr11:3078854 CARS 0.57 8.4 0.42 1.34e-15 Longevity; CRC cis rs826838 0.834 rs2387842 chr12:38736442 T/C cg13010199 chr12:38710504 ALG10B 0.48 6.21 0.32 1.56e-9 Heart rate; CRC cis rs9858542 0.953 rs34363169 chr3:49537712 G/A cg03060546 chr3:49711283 APEH -0.47 -6.56 -0.34 2.08e-10 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs6445525 0.967 rs2060022 chr3:65999755 A/G cg06109867 chr3:66002991 MAGI1 -0.4 -6.69 -0.35 9.87e-11 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs6831352 0.918 rs13127153 chr4:100058121 C/T cg12011299 chr4:100065546 ADH4 -0.49 -9.25 -0.45 3.02e-18 Alcohol dependence; CRC cis rs7771547 0.519 rs67313027 chr6:36363487 G/C cg07856975 chr6:36356162 ETV7 0.48 6.01 0.31 4.83e-9 Platelet distribution width; CRC cis rs10504229 0.683 rs6999984 chr8:58115079 G/A cg04204079 chr8:58130323 NA -0.45 -5.83 -0.31 1.34e-8 Developmental language disorder (linguistic errors); CRC cis rs6540559 1.000 rs12070337 chr1:209992127 G/A cg25204440 chr1:209979598 IRF6 0.51 6.63 0.34 1.35e-10 Cleft lip with or without cleft palate; CRC cis rs7552404 0.696 rs10518521 chr1:76461214 G/A cg22875332 chr1:76189707 ACADM 0.65 7.35 0.38 1.59e-12 Blood metabolite levels;Acylcarnitine levels; CRC cis rs738322 1.000 rs133009 chr22:38569653 G/C cg17652424 chr22:38574118 PLA2G6 -0.22 -6.81 -0.35 4.6e-11 Cutaneous nevi; CRC cis rs12142240 0.621 rs13374968 chr1:46843908 T/G cg14993813 chr1:46806288 NSUN4 -0.48 -6.05 -0.32 3.98e-9 Menopause (age at onset); CRC cis rs4722166 1.000 rs4722166 chr7:22738762 G/T cg05472934 chr7:22766657 IL6 0.62 8.67 0.43 1.95e-16 Lung cancer; CRC cis rs11622475 1.000 rs7143682 chr14:104413455 C/T cg12183467 chr14:104352244 NA -0.49 -6.76 -0.35 6.28e-11 Bipolar disorder; CRC cis rs72772090 0.539 rs72773923 chr5:96117579 G/A cg17330273 chr5:96107758 CAST;ERAP1 -0.63 -5.77 -0.3 1.79e-8 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs7258465 0.965 rs7253990 chr19:18604085 C/G cg06953865 chr19:18549723 ISYNA1 -0.38 -5.74 -0.3 2.11e-8 Breast cancer; CRC cis rs4523957 0.890 rs62069332 chr17:2112720 A/G cg16513277 chr17:2031491 SMG6 -0.52 -8.62 -0.43 2.82e-16 Autism spectrum disorder or schizophrenia;Schizophrenia; CRC cis rs1707322 1.000 rs4660332 chr1:46461418 T/A cg03146154 chr1:46216737 IPP 0.58 8.12 0.41 9.52e-15 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs1018836 0.923 rs13255452 chr8:91582988 A/G cg16814680 chr8:91681699 NA -0.73 -11.43 -0.53 1.02e-25 Ejection fraction in Tripanosoma cruzi seropositivity; CRC trans rs4942242 1.000 rs7331003 chr13:44230253 C/T cg26741380 chr15:41871084 TYRO3 -0.43 -6.57 -0.34 1.96e-10 Response to tocilizumab in rheumatoid arthritis; CRC cis rs644799 0.896 rs12146644 chr11:95492878 A/G cg25478527 chr11:95522999 CEP57;FAM76B 0.5 7.19 0.37 4.48e-12 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC trans rs7613875 0.600 rs2856237 chr3:50158774 A/G cg21665057 chr3:196295764 WDR53;FBXO45 -0.47 -6.97 -0.36 1.72e-11 Body mass index; CRC trans rs7615952 0.932 rs7630077 chr3:125649676 T/C cg07211511 chr3:129823064 LOC729375 -1.06 -18.13 -0.71 2.03e-51 Blood pressure (smoking interaction); CRC cis rs11098499 0.657 rs4463052 chr4:120313258 T/C cg24375607 chr4:120327624 NA 0.51 7.86 0.4 5.5e-14 Corneal astigmatism; CRC cis rs2439831 0.850 rs7181039 chr15:44179112 A/G cg02155558 chr15:43621948 ADAL;LCMT2 0.63 6.24 0.33 1.37e-9 Lung cancer in ever smokers; CRC cis rs8180040 0.726 rs11130110 chr3:47000606 T/C cg02527881 chr3:46936655 PTH1R -0.43 -8.16 -0.41 7.21e-15 Colorectal cancer; CRC cis rs10504229 0.775 rs17805110 chr8:58161439 C/G cg24829409 chr8:58192753 C8orf71 0.6 8.13 0.41 8.68e-15 Developmental language disorder (linguistic errors); CRC cis rs10751667 0.643 rs10902234 chr11:935578 A/G cg06064525 chr11:970664 AP2A2 -0.31 -6.16 -0.32 2.18e-9 Alzheimer's disease (late onset); CRC cis rs13144136 0.664 rs6448177 chr4:10666272 C/T cg10242279 chr4:10666415 CLNK -0.39 -6.61 -0.34 1.56e-10 Resistance to antihypertensive treatment in hypertension; CRC cis rs3924048 0.559 rs4075303 chr1:12626593 C/G cg23650765 chr1:12612165 NA 0.3 5.74 0.3 2.13e-8 Optic cup area; CRC cis rs796364 0.806 rs203765 chr2:200903020 G/A cg25936922 chr2:200820526 C2orf60;C2orf47 -0.68 -6.67 -0.34 1.11e-10 Schizophrenia; CRC cis rs10046574 0.656 rs17403326 chr7:135194440 T/G cg27474649 chr7:135195673 CNOT4 0.65 6.08 0.32 3.36e-9 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs17401966 1.000 rs4846210 chr1:10322153 A/G cg19773385 chr1:10388646 KIF1B -0.58 -8.04 -0.41 1.58e-14 Hepatocellular carcinoma; CRC cis rs1552244 1.000 rs3826 chr3:10141065 T/G cg02579736 chr3:10068473 FANCD2;CIDECP 0.92 12.66 0.57 3.43e-30 Alzheimer's disease; CRC cis rs853679 0.517 rs36078605 chr6:28078032 A/C cg15845792 chr6:28175446 NA 1.0 13.01 0.58 1.62e-31 Depression; CRC cis rs11148252 0.538 rs9535887 chr13:52730761 G/A cg12458913 chr13:53173898 NA 0.49 7.23 0.37 3.41e-12 Lewy body disease; CRC trans rs3774749 0.565 rs2624839 chr3:50202231 T/C cg21665057 chr3:196295764 WDR53;FBXO45 0.41 6.2 0.32 1.66e-9 Intelligence (multi-trait analysis); CRC trans rs564309 1.000 rs493950 chr1:228606965 C/T cg24066601 chr6:26271455 HIST1H3G -0.55 -5.98 -0.31 5.88e-9 Hip circumference (psychosocial stress interaction); CRC cis rs3816788 0.837 rs6557640 chr8:21771731 A/T cg08288130 chr8:21771540 DOK2 0.29 5.88 0.31 9.88e-9 Lung cancer in ever smokers; CRC cis rs9896933 0.561 rs2264375 chr17:80692709 T/A cg02398342 chr17:80708632 TBCD;FN3K 0.51 5.92 0.31 7.97e-9 Bone mineral accretion in asthma (oral corticosteroid dose interaction); CRC cis rs561341 1.000 rs2470243 chr17:30290955 C/T cg00745463 chr17:30367425 LRRC37B -0.89 -9.78 -0.47 5.21e-20 Hip circumference adjusted for BMI; CRC trans rs7976838 0.908 rs12821998 chr12:60117371 T/C cg16974014 chr22:22007515 MIR130B 0.49 5.97 0.31 6.13e-9 Response to zileuton treatment in asthma (FEV1 change interaction); CRC cis rs2745967 0.740 rs2745955 chr1:208064341 G/A cg09788693 chr1:208063733 CD34 0.44 6.45 0.33 4.04e-10 Resting heart rate; CRC cis rs7103648 0.630 rs7934481 chr11:47883337 C/T cg20307385 chr11:47447363 PSMC3 0.74 10.14 0.49 3.27e-21 Diastolic blood pressure;Systolic blood pressure; CRC cis rs9318086 0.578 rs75752641 chr13:24473240 A/G cg25267304 chr13:24462978 PCOTH;MIPEP 0.64 10.2 0.49 2.12e-21 Myopia (pathological); CRC cis rs1519814 0.696 rs2326434 chr8:121047798 A/C cg22335954 chr8:121166405 COL14A1 -0.62 -7.11 -0.37 7.2e-12 Breast cancer; CRC cis rs1799949 1.000 rs8074136 chr17:41342313 A/C cg01879757 chr17:41196368 BRCA1 -0.44 -6.71 -0.35 8.38e-11 Menopause (age at onset); CRC cis rs919433 0.963 rs1429417 chr2:198158171 T/G cg10820045 chr2:198174542 NA -0.55 -11.08 -0.52 1.79e-24 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC trans rs747782 0.528 rs10838881 chr11:48387275 T/C cg03929089 chr4:120376271 NA 0.63 6.15 0.32 2.29e-9 Intraocular pressure; CRC cis rs875971 0.825 rs28480509 chr7:66099224 A/G cg00343986 chr7:65444356 GUSB -0.45 -6.25 -0.33 1.25e-9 Aortic root size; CRC cis rs7772486 0.713 rs1986729 chr6:146194831 G/A cg23711669 chr6:146136114 FBXO30 0.74 12.67 0.57 3.12e-30 Lobe attachment (rater-scored or self-reported); CRC cis rs7212590 0.748 rs7213697 chr17:57903041 G/C cg10252138 chr17:58120427 NA -0.53 -5.61 -0.3 4.22e-8 Granulocyte percentage of myeloid white cells;Monocyte count;Monocyte percentage of white cells; CRC cis rs861020 0.630 rs592694 chr1:210009533 G/T cg09163369 chr1:210001066 C1orf107 0.41 5.78 0.3 1.72e-8 Orofacial clefts; CRC cis rs2276314 0.532 rs11081927 chr18:33614282 C/T cg19628046 chr18:33552617 C18orf21 0.4 6.22 0.32 1.49e-9 Endometriosis;Drug-induced torsades de pointes; CRC cis rs769267 0.930 rs1047361 chr19:19606634 G/A cg01262667 chr19:19385393 TM6SF2 0.36 5.87 0.31 1.06e-8 Tonsillectomy; CRC cis rs6424115 0.737 rs10917430 chr1:24170458 C/T cg10978503 chr1:24200527 CNR2 -0.44 -6.67 -0.35 1.06e-10 Immature fraction of reticulocytes; CRC trans rs1814175 0.935 rs1827017 chr11:49632592 C/G cg03929089 chr4:120376271 NA -0.94 -17.32 -0.69 3.26e-48 Height; CRC cis rs4731207 0.662 rs10246553 chr7:124494934 A/C cg23710748 chr7:124431027 NA -0.38 -6.08 -0.32 3.42e-9 Cutaneous malignant melanoma; CRC cis rs7626444 0.625 rs843530 chr3:196481024 A/G cg12930392 chr3:196481615 PAK2 0.38 6.67 0.35 1.1e-10 Monocyte count; CRC cis rs873946 0.504 rs12254034 chr10:134571007 T/C cg18305652 chr10:134549665 INPP5A 0.54 7.81 0.4 7.52e-14 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CRC cis rs2404602 0.647 rs12903331 chr15:77168268 C/G cg03037974 chr15:76606532 NA -0.55 -8.23 -0.41 4.33e-15 Blood metabolite levels; CRC trans rs7937682 0.889 rs1784785 chr11:111483306 A/G cg18187862 chr3:45730750 SACM1L 0.45 6.55 0.34 2.23e-10 Primary sclerosing cholangitis; CRC cis rs561341 1.000 rs113676348 chr17:30244327 A/G cg19193384 chr17:30244184 NA -0.58 -7.03 -0.36 1.19e-11 Hip circumference adjusted for BMI; CRC cis rs910316 0.737 rs175043 chr14:75471803 G/A cg03030879 chr14:75389066 RPS6KL1 0.41 6.11 0.32 2.83e-9 Height; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg24787076 chr5:40834616 RPL37 0.45 7.25 0.37 3e-12 Liver disease severity in Alagille syndrome; CRC cis rs7412746 0.611 rs6660084 chr1:150748803 T/C cg18016565 chr1:150552671 MCL1 0.43 5.95 0.31 6.7e-9 Melanoma; CRC cis rs9039 0.918 rs12933086 chr16:9225494 A/G cg08831531 chr16:9218945 NA -0.59 -6.92 -0.36 2.33e-11 Menopause (age at onset); CRC cis rs8072100 0.790 rs3760371 chr17:45695914 T/C cg08085267 chr17:45401833 C17orf57 0.56 8.44 0.42 1.02e-15 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs67311347 0.544 rs7644643 chr3:40350209 C/T cg09455208 chr3:40491958 NA -0.33 -6.82 -0.35 4.42e-11 Renal cell carcinoma; CRC cis rs73200209 0.744 rs10507269 chr12:116560327 A/T cg01776926 chr12:116560359 MED13L -0.6 -7.26 -0.37 2.75e-12 Total body bone mineral density; CRC cis rs7914558 1.000 rs7071373 chr10:104771922 A/G cg15744005 chr10:104629667 AS3MT -0.32 -6.83 -0.35 4.22e-11 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs6545883 0.895 rs2421192 chr2:61643631 T/C cg15711740 chr2:61764176 XPO1 0.43 5.84 0.31 1.23e-8 Tuberculosis; CRC cis rs736408 0.522 rs6445535 chr3:52771468 T/C cg10802521 chr3:52805072 NEK4 -0.57 -8.87 -0.44 4.63e-17 Bipolar disorder; CRC cis rs10751667 0.961 rs10794358 chr11:985547 C/T cg23136738 chr11:925521 AP2A2 -0.48 -7.63 -0.39 2.52e-13 Alzheimer's disease (late onset); CRC trans rs4346635 0.528 rs6827369 chr4:81416967 C/T cg13904968 chr20:56136012 PCK1 -0.19 -6.02 -0.31 4.64e-9 Colonoscopy-negative controls vs population controls; CRC cis rs262150 0.530 rs2730232 chr7:158784469 C/T cg10570241 chr7:158785291 NA -0.43 -6.5 -0.34 2.92e-10 Facial morphology (factor 20); CRC cis rs28386778 0.897 rs2584624 chr17:61904546 A/G cg22520471 chr17:61851767 DDX42;CCDC47 0.75 11.79 0.55 5.3e-27 Prudent dietary pattern; CRC cis rs929354 0.553 rs34498858 chr7:156931337 T/C cg17757837 chr7:157058334 UBE3C 0.72 11.91 0.55 1.97e-27 Body mass index; CRC cis rs6461049 0.765 rs4719431 chr7:2140312 T/C cg22963979 chr7:1858916 MAD1L1 -0.43 -6.54 -0.34 2.33e-10 Schizophrenia; CRC cis rs4925325 0.955 rs1776262 chr20:60516023 G/T cg06108461 chr20:60628389 TAF4 0.5 6.94 0.36 2.06e-11 Obesity-related traits; CRC cis rs4722166 0.567 rs62449490 chr7:22748491 T/G cg05472934 chr7:22766657 IL6 0.41 6.05 0.32 3.88e-9 Lung cancer; CRC cis rs394563 0.622 rs237024 chr6:149721965 T/C cg11245181 chr6:149772854 ZC3H12D -0.6 -10.66 -0.51 5.65e-23 Dupuytren's disease; CRC cis rs7666738 0.830 rs28818180 chr4:98953625 A/G cg17366294 chr4:99064904 C4orf37 0.43 7.34 0.38 1.69e-12 Colonoscopy-negative controls vs population controls; CRC cis rs13256369 1.000 rs7004438 chr8:8574379 C/T cg06671706 chr8:8559999 CLDN23 0.55 8.15 0.41 7.92e-15 Obesity-related traits; CRC cis rs7762018 1.000 rs73242927 chr6:170129573 T/A cg24289452 chr6:170231220 NA -0.58 -6.58 -0.34 1.81e-10 Thiazide-induced adverse metabolic effects in hypertensive patients; CRC cis rs853679 0.517 rs17711801 chr6:28092307 C/G cg12963246 chr6:28129442 ZNF389 0.49 5.78 0.3 1.73e-8 Depression; CRC cis rs7258465 1.000 rs7252707 chr19:18612257 G/A cg01065977 chr19:18549689 ISYNA1 -0.4 -6.21 -0.32 1.6e-9 Breast cancer; CRC cis rs10751667 0.560 rs7924794 chr11:962745 A/T cg01483505 chr11:975446 AP2A2 0.46 7.5 0.38 5.98e-13 Alzheimer's disease (late onset); CRC cis rs7914558 0.933 rs10786729 chr10:104719378 A/G cg04362960 chr10:104952993 NT5C2 0.61 9.23 0.45 3.48e-18 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs904251 0.504 rs2797795 chr6:37480683 T/C cg25019722 chr6:37503610 NA -0.47 -8.73 -0.43 1.28e-16 Cognitive performance; CRC cis rs832540 0.931 rs832536 chr5:56212595 C/T cg24531977 chr5:56204891 C5orf35 -0.5 -7.61 -0.39 2.85e-13 Coronary artery disease; CRC cis rs6762 0.748 rs7929032 chr11:839078 G/A cg15787769 chr11:842744 TSPAN4;POLR2L -0.46 -6.57 -0.34 2.01e-10 Mean platelet volume; CRC trans rs7618501 1.000 rs3749240 chr3:49750188 T/A cg21582582 chr3:182698605 DCUN1D1 -0.56 -8.23 -0.41 4.33e-15 Intelligence (multi-trait analysis); CRC cis rs9611565 0.685 rs169363 chr22:41853117 G/T cg03806693 chr22:41940476 POLR3H 0.96 13.13 0.59 5.94e-32 Vitiligo; CRC cis rs9733 0.544 rs72700902 chr1:150633347 C/T cg10589385 chr1:150898437 SETDB1 0.29 6.2 0.32 1.7e-9 Tonsillectomy; CRC cis rs853679 0.517 rs1904841 chr6:28108085 C/T cg12273811 chr6:28175739 NA 0.71 8.94 0.44 2.8e-17 Depression; CRC trans rs6733379 0.588 rs2193790 chr2:34445953 A/G cg08325383 chr11:65190187 NEAT1 -0.42 -6.16 -0.32 2.13e-9 Attention deficit hyperactivity disorder and conduct disorder; CRC cis rs10504229 0.683 rs56741275 chr8:58136108 C/G cg24829409 chr8:58192753 C8orf71 -0.55 -8.03 -0.4 1.71e-14 Developmental language disorder (linguistic errors); CRC trans rs10504229 1.000 rs61733801 chr8:58192513 A/G cg04077850 chr5:125800366 GRAMD3 0.37 6.27 0.33 1.15e-9 Developmental language disorder (linguistic errors); CRC cis rs7909074 0.766 rs5000415 chr10:45383674 C/T cg04218760 chr10:45406644 TMEM72 -0.34 -9.55 -0.47 3.15e-19 Mean corpuscular volume; CRC cis rs875971 0.545 rs10950025 chr7:65623933 G/A cg02869306 chr7:64672164 INTS4L1 -0.43 -6.18 -0.32 1.86e-9 Aortic root size; CRC cis rs7772486 0.720 rs702320 chr6:146006654 G/A cg13319975 chr6:146136371 FBXO30 0.45 6.65 0.34 1.25e-10 Lobe attachment (rater-scored or self-reported); CRC cis rs9925964 0.933 rs9939417 chr16:31053467 C/T cg03418659 chr16:31128414 MYST1 0.47 6.79 0.35 5.22e-11 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs17384381 0.859 rs28529751 chr1:85910951 G/A cg16011679 chr1:85725395 C1orf52 0.57 6.15 0.32 2.27e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs34779708 0.931 rs72789690 chr10:35382817 T/C cg03585969 chr10:35415529 CREM 0.67 8.87 0.44 4.78e-17 Inflammatory bowel disease;Crohn's disease; CRC cis rs9527 0.662 rs10883783 chr10:104591152 T/A cg15744005 chr10:104629667 AS3MT -0.35 -6.43 -0.33 4.37e-10 Arsenic metabolism; CRC cis rs2637266 0.561 rs10824441 chr10:78490195 G/A cg18941641 chr10:78392320 NA -0.36 -6.03 -0.32 4.46e-9 Pulmonary function; CRC cis rs853679 0.517 rs9380047 chr6:28037893 G/T cg23161317 chr6:28129485 ZNF389 0.53 6.52 0.34 2.57e-10 Depression; CRC cis rs6860806 0.507 rs273915 chr5:131660119 G/C cg12564285 chr5:131593104 PDLIM4 0.45 7.49 0.38 6.2800000000000005e-13 Breast cancer; CRC cis rs9911578 0.934 rs8081967 chr17:57072701 T/C cg12560992 chr17:57184187 TRIM37 0.94 17.29 0.69 4.4e-48 Intelligence (multi-trait analysis); CRC cis rs2692947 0.673 rs2692894 chr2:96784934 T/G cg23100626 chr2:96804247 ASTL -0.31 -8.53 -0.43 5.55e-16 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; CRC cis rs6951245 1.000 rs78628466 chr7:1068453 G/C cg24642844 chr7:1081250 C7orf50 -0.78 -9.35 -0.46 1.42e-18 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs9291683 0.588 rs12507330 chr4:10002195 G/A cg11266682 chr4:10021025 SLC2A9 0.49 10.49 0.5 2.11e-22 Bone mineral density; CRC cis rs9914988 0.943 rs12951232 chr17:27132638 G/C cg12682573 chr17:27188876 MIR451;MIR144 0.58 7.99 0.4 2.37e-14 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs4716602 0.596 rs36013171 chr7:156160511 C/T cg16983916 chr7:156159713 NA -0.39 -6.9 -0.36 2.65e-11 Anti-saccade response; CRC cis rs7246760 1.000 rs73507215 chr19:9887312 C/T cg16876255 chr19:9731953 ZNF561 0.69 5.71 0.3 2.49e-8 Pursuit maintenance gain; CRC cis rs6938 0.534 rs11636892 chr15:75266049 G/C cg09165964 chr15:75287851 SCAMP5 0.55 8.19 0.41 5.84e-15 Breast cancer; CRC cis rs853679 0.517 rs3757185 chr6:28107776 T/A cg12963246 chr6:28129442 ZNF389 0.49 5.78 0.3 1.73e-8 Depression; CRC cis rs7264396 0.887 rs2236161 chr20:34101631 C/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.39 -6.47 -0.34 3.51e-10 Total cholesterol levels; CRC cis rs225245 0.782 rs225293 chr17:33925906 A/G cg05299278 chr17:33885742 SLFN14 0.48 7.91 0.4 3.98e-14 Reticulocyte count;Reticulocyte fraction of red cells;High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells; CRC cis rs7615952 0.736 rs11921945 chr3:125643719 A/G cg05084668 chr3:125655381 ALG1L -0.58 -8.49 -0.42 6.96e-16 Blood pressure (smoking interaction); CRC cis rs2286885 1.000 rs10760439 chr9:129250830 A/C cg15282417 chr9:129245246 FAM125B 0.47 8.78 0.44 9.18e-17 Intraocular pressure; CRC cis rs12760731 0.623 rs16852708 chr1:178308249 T/G cg00404053 chr1:178313656 RASAL2 0.73 9.14 0.45 6.55e-18 Obesity-related traits; CRC cis rs12142240 0.698 rs68191463 chr1:46808695 T/C cg00530320 chr1:46809349 NSUN4 0.58 7.98 0.4 2.46e-14 Menopause (age at onset); CRC cis rs2277425 0.755 rs2277424 chr13:111522420 A/G cg04513422 chr13:111522314 C13orf29 -0.7 -8.84 -0.44 5.83e-17 Sitting height ratio; CRC cis rs2228479 1.000 rs62052186 chr16:89969567 A/T cg06656553 chr16:89960601 TCF25 -0.69 -6.15 -0.32 2.21e-9 Skin colour saturation; CRC cis rs2243480 1.000 rs13220979 chr7:65363204 G/A cg12463550 chr7:65579703 CRCP 0.65 6.08 0.32 3.28e-9 Diabetic kidney disease; CRC cis rs3820928 0.934 rs1366756 chr2:227772038 G/A cg11843606 chr2:227700838 RHBDD1 -0.41 -5.92 -0.31 7.98e-9 Pulmonary function; CRC cis rs28386778 0.897 rs1043127 chr17:61791210 T/G cg22520471 chr17:61851767 DDX42;CCDC47 0.74 11.2 0.53 6.69e-25 Prudent dietary pattern; CRC cis rs9443645 0.545 rs10755377 chr6:79637925 T/C cg09184832 chr6:79620586 NA -0.46 -8.07 -0.41 1.32e-14 Intelligence (multi-trait analysis); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg06544376 chr20:18548101 LOC388789 0.39 6.37 0.33 6.22e-10 Liver disease severity in Alagille syndrome; CRC cis rs6502050 0.740 rs4789748 chr17:80093061 A/C cg13198984 chr17:80129470 CCDC57 0.44 7.8 0.4 8.18e-14 Life satisfaction; CRC trans rs2797160 0.967 rs2747718 chr6:126009109 C/A cg05039488 chr6:79577232 IRAK1BP1 0.49 7.3 0.37 2.11e-12 Endometrial cancer; CRC cis rs7527798 0.592 rs10863437 chr1:207817612 T/C cg21110645 chr1:207815933 NA -0.39 -5.87 -0.31 1.08e-8 Erythrocyte sedimentation rate; CRC cis rs28386778 0.897 rs9915552 chr17:61869095 G/A cg22520471 chr17:61851767 DDX42;CCDC47 0.76 11.7 0.54 1.1e-26 Prudent dietary pattern; CRC cis rs889312 0.500 rs866223 chr5:56125353 A/G cg03609598 chr5:56110824 MAP3K1 -0.45 -6.15 -0.32 2.18e-9 Breast cancer;Breast cancer (early onset); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg04950361 chr8:22552624 NA 0.45 6.35 0.33 7.11e-10 Response to antipsychotic treatment; CRC cis rs853679 0.542 rs6934769 chr6:28090931 A/G cg02631126 chr6:28058918 ZSCAN12L1 0.29 5.89 0.31 9.41e-9 Depression; CRC cis rs2882667 0.690 rs274119 chr5:138064219 G/A cg09476006 chr5:138032270 NA 0.58 10.42 0.5 3.74e-22 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs36715 0.953 rs36700 chr5:127551273 A/G cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.59 7.35 0.38 1.59e-12 Breast cancer; CRC cis rs514406 0.893 rs512723 chr1:53343880 C/T cg27535305 chr1:53392650 SCP2 0.36 6.3 0.33 9.47e-10 Monocyte count; CRC cis rs12410462 1.000 rs75198003 chr1:227623853 C/A cg04117972 chr1:227635322 NA 0.69 7.82 0.4 7.23e-14 Major depressive disorder; CRC cis rs9527 0.640 rs7089061 chr10:104723015 C/A cg04362960 chr10:104952993 NT5C2 0.6 8.59 0.43 3.61e-16 Arsenic metabolism; CRC cis rs79387448 0.810 rs75218113 chr2:103239356 C/G cg21010569 chr2:103233596 NA 0.58 6.2 0.32 1.67e-9 Gut microbiota (bacterial taxa); CRC trans rs2303319 0.582 rs12464282 chr2:162448855 C/T cg10272801 chr16:14013773 ERCC4 -0.68 -6.01 -0.31 4.9e-9 Cognitive function; CRC cis rs6540559 0.932 rs764093 chr1:209983331 A/G cg22029157 chr1:209979665 IRF6 0.65 9.73 0.47 8.13e-20 Cleft lip with or without cleft palate; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg01940867 chr16:431543 TMEM8A;LOC100134368 0.42 6.15 0.32 2.27e-9 Intelligence (multi-trait analysis); CRC cis rs78456975 0.607 rs73909625 chr2:1541934 A/G cg26248373 chr2:1572462 NA -0.61 -6.45 -0.34 3.98e-10 Placebo response in major depressive disorder (% change in symptom score); CRC cis rs7605827 0.704 rs62120513 chr2:15537727 T/A cg19274914 chr2:15703543 NA 0.4 5.94 0.31 7.2e-9 Educational attainment (years of education); CRC cis rs1048238 0.506 rs848210 chr1:16259813 A/G cg21385522 chr1:16154831 NA -0.59 -8.5 -0.42 6.71e-16 Systolic blood pressure; CRC cis rs9368481 0.743 rs9368480 chr6:26955750 A/C cg10547057 chr6:26987810 LOC100270746;C6orf41 0.4 5.63 0.3 3.87e-8 Autism spectrum disorder or schizophrenia; CRC trans rs2303319 0.504 rs56153413 chr2:162440079 G/T cg18122310 chr12:50236657 BCDIN3D -0.73 -6.15 -0.32 2.18e-9 Cognitive function; CRC cis rs6912958 1.000 rs9450701 chr6:88173167 T/C cg12350822 chr6:88032061 C6orf162;GJB7 -0.37 -7.09 -0.36 8.4e-12 Monocyte percentage of white cells; CRC cis rs1218582 0.772 rs2174507 chr1:154887949 C/T cg09359103 chr1:154839909 KCNN3 -0.71 -12.61 -0.57 5.17e-30 Prostate cancer; CRC trans rs11722228 0.522 rs62286604 chr4:10131161 A/G cg26043149 chr18:55253948 FECH 1.14 18.98 0.72 8.64e-55 Gout;Urate levels;Serum uric acid levels; CRC trans rs853679 1.000 rs6901575 chr6:28250984 G/A cg06606381 chr12:133084897 FBRSL1 -0.63 -6.26 -0.33 1.17e-9 Depression; CRC cis rs929354 0.707 rs1182445 chr7:157024428 C/G cg16102536 chr7:156981717 UBE3C -0.4 -6.8 -0.35 4.8e-11 Body mass index; CRC cis rs13118159 0.556 rs4974615 chr4:1373551 A/G cg05025164 chr4:1340916 KIAA1530 -0.52 -7.52 -0.38 5.25e-13 Longevity; CRC cis rs12188164 1.000 rs34453673 chr5:434722 G/C cg16322479 chr5:444228 EXOC3;C5orf55 0.49 7.87 0.4 5.16e-14 Cystic fibrosis severity; CRC cis rs9584850 0.794 rs17574433 chr13:99138057 A/G cg07423050 chr13:99094983 FARP1 -0.42 -5.76 -0.3 1.97e-8 Neuroticism; CRC trans rs561341 0.783 rs512698 chr17:30292507 G/T cg27661571 chr11:113659931 NA -0.95 -11.08 -0.52 1.91e-24 Hip circumference adjusted for BMI; CRC cis rs1799949 0.860 rs8176279 chr17:41210396 A/C cg05368731 chr17:41323189 NBR1 0.58 8.78 0.44 8.98e-17 Menopause (age at onset); CRC trans rs6951245 0.706 rs28522260 chr7:1183964 C/A cg13565492 chr6:43139072 SRF -0.73 -8.04 -0.41 1.6e-14 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC trans rs61931739 0.534 rs12371021 chr12:34062252 T/C cg26384229 chr12:38710491 ALG10B 0.54 6.86 0.35 3.41e-11 Morning vs. evening chronotype; CRC cis rs6540559 0.673 rs7550857 chr1:209956542 C/A cg21951975 chr1:209979733 IRF6 0.49 6.51 0.34 2.87e-10 Cleft lip with or without cleft palate; CRC cis rs8180040 1.000 rs295458 chr3:47385585 C/A cg10298567 chr3:47292165 KIF9 -0.39 -6.59 -0.34 1.74e-10 Colorectal cancer; CRC cis rs1218582 0.772 rs12095061 chr1:154912968 A/T cg09359103 chr1:154839909 KCNN3 -0.7 -12.19 -0.56 1.92e-28 Prostate cancer; CRC cis rs172166 0.611 rs203882 chr6:28078502 G/A cg10876282 chr6:28092338 ZSCAN16 0.5 6.6 0.34 1.61e-10 Cardiac Troponin-T levels; CRC cis rs10256972 0.553 rs4236381 chr7:1165723 A/C cg26608667 chr7:1196370 ZFAND2A 0.4 6.21 0.32 1.56e-9 Longevity;Endometriosis; CRC cis rs250677 0.687 rs384979 chr5:148459267 C/T cg23229984 chr5:148520753 ABLIM3 -0.47 -6.32 -0.33 8.56e-10 Breast cancer; CRC cis rs34779708 0.966 rs11010122 chr10:35493518 A/C cg03585969 chr10:35415529 CREM 0.55 7.4 0.38 1.17e-12 Inflammatory bowel disease;Crohn's disease; CRC cis rs7568458 0.846 rs6743030 chr2:85763520 C/T cg02493740 chr2:85810744 VAMP5 -0.39 -6.16 -0.32 2.11e-9 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg22211233 chr3:182817584 MCCC1 0.48 6.6 0.34 1.61e-10 Thyroid stimulating hormone; CRC trans rs11098499 0.739 rs6534130 chr4:120131339 A/T cg25214090 chr10:38739885 LOC399744 -0.43 -6.74 -0.35 7.17e-11 Corneal astigmatism; CRC cis rs7107174 1.000 rs7117238 chr11:78040259 G/A cg02023728 chr11:77925099 USP35 0.45 8.04 0.41 1.64e-14 Testicular germ cell tumor; CRC cis rs72781680 0.898 rs7589440 chr2:24038595 G/A cg08917208 chr2:24149416 ATAD2B 0.9 9.13 0.45 6.96e-18 Lymphocyte counts; CRC cis rs56104184 0.668 rs73063523 chr19:49408943 T/C cg15549821 chr19:49342101 PLEKHA4 -0.53 -5.98 -0.31 5.86e-9 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; CRC cis rs58799304 0.618 rs3814314 chr1:156045183 T/A cg15685922 chr1:156045208 MEX3A -0.48 -8.07 -0.41 1.37e-14 Ischemic stroke; CRC cis rs2294693 0.947 rs6924722 chr6:41002195 C/T cg14769373 chr6:40998127 UNC5CL 0.5 6.93 0.36 2.29e-11 Gastric cancer;Non-cardia gastric cancer; CRC cis rs853679 0.517 rs9393895 chr6:28127621 T/C cg12172441 chr6:28176163 NA 0.63 7.45 0.38 8.22e-13 Depression; CRC cis rs6696846 0.630 rs6692706 chr1:205158561 G/T cg03948781 chr1:205179583 DSTYK 0.43 6.0 0.31 5.27e-9 Red blood cell count; CRC cis rs208520 0.690 rs12213928 chr6:66762978 G/A cg07460842 chr6:66804631 NA 1.05 14.56 0.63 2.04e-37 Exhaled nitric oxide output; CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg17956079 chr11:73358572 PLEKHB1 -0.5 -6.38 -0.33 6.18e-10 Diisocyanate-induced asthma; CRC trans rs7395662 0.791 rs11040136 chr11:48939791 T/G cg21153622 chr11:89784906 NA 0.47 7.41 0.38 1.08e-12 HDL cholesterol; CRC cis rs2115630 1.000 rs6496441 chr15:85363348 A/G cg11189052 chr15:85197271 WDR73 -0.57 -9.24 -0.45 3.22e-18 P wave terminal force; CRC cis rs6933660 0.646 rs6915598 chr6:151778664 T/C cg14262678 chr6:151773367 RMND1;C6orf211 0.42 6.02 0.31 4.7e-9 Menarche (age at onset); CRC cis rs6860806 0.507 rs2631371 chr5:131703691 G/A cg18758796 chr5:131593413 PDLIM4 -0.41 -6.66 -0.34 1.14e-10 Breast cancer; CRC cis rs3858526 0.606 rs10838883 chr11:5952147 G/A cg02574844 chr11:5959923 NA 0.59 10.28 0.49 1.14e-21 DNA methylation (variation); CRC cis rs2404602 0.583 rs12592501 chr15:76554790 C/A cg03037974 chr15:76606532 NA 0.83 16.99 0.68 6.28e-47 Blood metabolite levels; CRC cis rs13082711 0.554 rs13087873 chr3:27392326 C/T cg02860705 chr3:27208620 NA 0.85 10.95 0.52 5.53e-24 Systolic blood pressure;Diastolic blood pressure;Blood pressure; CRC cis rs2730245 0.505 rs1188956 chr7:158690576 G/A cg23730037 chr7:158596552 ESYT2 -0.39 -5.63 -0.3 3.89e-8 Height; CRC cis rs6961069 0.774 rs1413661 chr7:80243003 G/C cg04458919 chr7:80252533 CD36 -0.36 -6.4 -0.33 5.29e-10 Platelet count; CRC cis rs9768139 0.708 rs10233815 chr7:158114348 C/T cg24154853 chr7:158122151 PTPRN2 0.59 9.88 0.48 2.43e-20 Calcium levels; CRC trans rs7580658 0.614 rs7585198 chr2:127962635 C/T cg22738278 chr10:104220943 TMEM180 -0.42 -6.04 -0.32 4.07e-9 Protein C levels; CRC cis rs6570726 0.764 rs9403726 chr6:145901686 G/T cg13319975 chr6:146136371 FBXO30 -0.41 -6.01 -0.31 4.85e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs1005277 0.577 rs4934906 chr10:38015028 C/T cg25517755 chr10:38738941 LOC399744 -0.45 -6.64 -0.34 1.27e-10 Extrinsic epigenetic age acceleration; CRC cis rs2576037 0.526 rs1893427 chr18:44434987 C/T cg24750912 chr18:44543259 TCEB3CL;KATNAL2 0.29 5.9 0.31 9.13e-9 Personality dimensions; CRC cis rs9462846 0.887 rs6458311 chr6:42866292 A/G cg21280719 chr6:42927975 GNMT -0.33 -6.49 -0.34 3.09e-10 Blood protein levels; CRC cis rs2404602 0.583 rs12908334 chr15:76581592 C/T cg23625390 chr15:77176239 SCAPER 0.4 5.92 0.31 8.29e-9 Blood metabolite levels; CRC cis rs8072100 0.817 rs9892497 chr17:45545919 G/A cg25173405 chr17:45401733 C17orf57 -0.44 -6.78 -0.35 5.45e-11 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs9393692 0.902 rs6456711 chr6:26302572 A/C cg00631329 chr6:26305371 NA -0.69 -12.89 -0.58 4.51e-31 Educational attainment; CRC cis rs6598955 0.670 rs6676619 chr1:26539035 T/G cg00852783 chr1:26633632 UBXN11 0.45 7.29 0.37 2.29e-12 Obesity-related traits; CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg11970458 chr16:31213481 PYCARD -0.55 -6.89 -0.36 2.81e-11 Diisocyanate-induced asthma; CRC cis rs9398803 0.830 rs2039735 chr6:126745076 T/C cg19875578 chr6:126661172 C6orf173 0.42 5.94 0.31 7.42e-9 Male-pattern baldness; CRC cis rs12230513 0.732 rs55797706 chr12:55836585 G/A cg19537932 chr12:55886519 OR6C68 -0.73 -9.49 -0.46 5.01e-19 Contrast sensitivity; CRC cis rs4730250 0.634 rs257371 chr7:106795043 C/A cg02696742 chr7:106810147 HBP1 -0.59 -6.66 -0.34 1.14e-10 Osteoarthritis; CRC cis rs4253772 0.591 rs6007748 chr22:46657798 A/G cg24881330 chr22:46731750 TRMU 0.59 7.01 0.36 1.33e-11 LDL cholesterol;Cholesterol, total; CRC cis rs6738485 0.567 rs7598745 chr2:106848216 A/T cg16099169 chr2:106886729 NA 0.33 5.71 0.3 2.58e-8 Pursuit maintenance gain;Pursuit maintenance gain in psychotic disorders; CRC trans rs8089364 0.917 rs2045439 chr18:57883801 C/T cg05871254 chr17:14213225 HS3ST3B1 -0.44 -6.23 -0.32 1.46e-9 Type 2 diabetes;Body mass index; CRC cis rs7618915 0.501 rs7624716 chr3:52751534 T/C cg10802521 chr3:52805072 NEK4 -0.58 -9.05 -0.45 1.31e-17 Bipolar disorder; CRC cis rs2228479 0.702 rs17233441 chr16:89817998 C/G cg06656553 chr16:89960601 TCF25 -0.69 -5.74 -0.3 2.15e-8 Skin colour saturation; CRC cis rs2976388 0.566 rs2585146 chr8:143798641 A/C cg20041105 chr8:143859282 LYNX1 0.45 7.4 0.38 1.12e-12 Urinary tract infection frequency; CRC cis rs951366 0.789 rs823152 chr1:205736285 G/A cg24503407 chr1:205819492 PM20D1 0.86 13.55 0.6 1.52e-33 Menarche (age at onset); CRC cis rs4731207 0.596 rs4624966 chr7:124626471 C/A cg23710748 chr7:124431027 NA -0.4 -6.38 -0.33 6.15e-10 Cutaneous malignant melanoma; CRC trans rs7726839 0.540 rs72703095 chr5:601789 T/C cg25482853 chr8:67687455 SGK3 1.11 12.97 0.58 2.45e-31 Obesity-related traits; CRC cis rs9325144 0.510 rs7952795 chr12:38720686 C/T cg26384229 chr12:38710491 ALG10B 0.58 8.57 0.43 4.13e-16 Morning vs. evening chronotype; CRC cis rs853679 0.517 rs9380052 chr6:28064623 A/G cg12172441 chr6:28176163 NA 0.64 7.59 0.39 3.28e-13 Depression; CRC cis rs9527 0.830 rs10883790 chr10:104640955 A/C cg04362960 chr10:104952993 NT5C2 0.64 8.38 0.42 1.6e-15 Arsenic metabolism; CRC cis rs12681287 0.605 rs13262672 chr8:87355812 T/C cg27223183 chr8:87520930 FAM82B -0.52 -6.96 -0.36 1.89e-11 Caudate activity during reward; CRC cis rs7264396 0.790 rs6121015 chr20:34243017 C/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.59 -9.84 -0.48 3.48e-20 Total cholesterol levels; CRC cis rs7618915 0.501 rs3733041 chr3:52731598 T/C cg08222913 chr3:52553049 STAB1 -0.33 -6.11 -0.32 2.86e-9 Bipolar disorder; CRC cis rs10256972 0.567 rs2960835 chr7:1202963 A/G cg22907277 chr7:1156413 C7orf50 0.66 10.07 0.49 5.68e-21 Longevity;Endometriosis; CRC cis rs5753618 0.583 rs5753628 chr22:31860322 A/G cg07713946 chr22:31675144 LIMK2 0.37 5.74 0.3 2.18e-8 Colorectal cancer; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg05930162 chr1:46152207 GPBP1L1 0.48 6.81 0.35 4.65e-11 Response to antipsychotic treatment; CRC cis rs72781680 0.560 rs111310684 chr2:24265682 C/G cg20701182 chr2:24300061 SF3B14 0.59 6.69 0.35 9.34e-11 Lymphocyte counts; CRC cis rs919433 0.783 rs2565155 chr2:198236425 A/G cg10820045 chr2:198174542 NA 0.45 7.89 0.4 4.58e-14 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC cis rs6456156 0.711 rs1855025 chr6:167537594 A/G cg07513332 chr6:167530253 CCR6 -0.46 -8.49 -0.42 7.24e-16 Primary biliary cholangitis; CRC cis rs12497850 0.931 rs7626445 chr3:49114544 C/T cg20833759 chr3:49053208 WDR6;DALRD3 0.52 8.63 0.43 2.68e-16 Parkinson's disease; CRC cis rs7618915 0.547 rs11720432 chr3:52672742 T/C cg15147215 chr3:52552868 STAB1 -0.62 -10.28 -0.49 1.15e-21 Bipolar disorder; CRC cis rs6908034 0.607 rs62404179 chr6:19806272 T/C cg02682789 chr6:19804855 NA 0.8 6.79 0.35 5.36e-11 Endometriosis;Deep ovarian and/or rectovaginal disease with dense adhesions; CRC cis rs4481887 0.927 rs6587444 chr1:248438452 C/T cg13385794 chr1:248469461 NA -0.37 -6.56 -0.34 2.05e-10 Common traits (Other); CRC cis rs7618915 0.547 rs11130314 chr3:52697082 T/C cg18404041 chr3:52824283 ITIH1 -0.43 -8.74 -0.43 1.21e-16 Bipolar disorder; CRC cis rs4819052 0.851 rs8133045 chr21:46658137 A/G cg11663144 chr21:46675770 NA -0.83 -14.12 -0.61 9.88e-36 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs6570726 0.935 rs366621 chr6:145861275 A/G cg05347473 chr6:146136440 FBXO30 0.4 6.34 0.33 7.4e-10 Lobe attachment (rater-scored or self-reported); CRC cis rs28386778 0.897 rs8073515 chr17:61795328 A/C cg06601766 chr17:61851465 DDX42;CCDC47 0.43 5.8 0.3 1.54e-8 Prudent dietary pattern; CRC cis rs2197308 0.765 rs11182964 chr12:37935052 C/T cg26384229 chr12:38710491 ALG10B 0.68 8.97 0.44 2.37e-17 Morning vs. evening chronotype; CRC cis rs13108904 0.870 rs12506095 chr4:1262233 T/C cg19318889 chr4:1322082 MAEA 0.4 5.69 0.3 2.83e-8 Obesity-related traits; CRC cis rs1552244 0.882 rs3732966 chr3:10015740 C/T cg10729496 chr3:10149963 C3orf24 0.48 6.25 0.33 1.25e-9 Alzheimer's disease; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg21815536 chr7:35840623 SEPT7 0.38 6.01 0.31 5e-9 Intelligence (multi-trait analysis); CRC cis rs2032447 0.798 rs807212 chr6:26065621 A/G cg18357526 chr6:26021779 HIST1H4A 0.78 11.9 0.55 2.15e-27 Intelligence (multi-trait analysis); CRC cis rs12477438 0.798 rs10167015 chr2:99570707 C/T cg14399236 chr2:99771627 LIPT1;TSGA10 -0.66 -9.34 -0.46 1.49e-18 Chronic sinus infection; CRC cis rs4713118 0.824 rs2092075 chr6:27749330 G/C cg06470822 chr6:28175283 NA 0.74 10.0 0.48 9.56e-21 Parkinson's disease; CRC cis rs9858542 0.953 rs1801143 chr3:49570200 C/T cg07274523 chr3:49395745 GPX1 0.48 6.56 0.34 2.13e-10 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs9399135 0.967 rs3756799 chr6:135341011 A/G cg24558204 chr6:135376177 HBS1L 0.52 8.15 0.41 7.84e-15 Red blood cell count; CRC cis rs6952808 0.531 rs3779002 chr7:2183219 C/T cg02951883 chr7:2050386 MAD1L1 -0.6 -8.97 -0.44 2.29e-17 Bipolar disorder and schizophrenia; CRC cis rs7216064 0.655 rs8078543 chr17:66037251 G/T cg12091567 chr17:66097778 LOC651250 0.9 13.66 0.6 5.87e-34 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CRC cis rs2549003 1.000 rs9282761 chr5:131822224 T/C cg21138405 chr5:131827807 IRF1 0.57 11.38 0.53 1.59e-25 Asthma (sex interaction); CRC cis rs9534288 0.797 rs2104516 chr13:46602123 T/C cg15192986 chr13:46630673 CPB2 -0.67 -9.81 -0.48 4.16e-20 Blood protein levels; CRC cis rs13191362 1.000 rs7764785 chr6:163009967 A/G cg06582575 chr6:163149167 PACRG;PARK2 0.75 10.24 0.49 1.58e-21 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC trans rs7580658 0.614 rs7585198 chr2:127962635 C/T cg12692199 chr17:7138010 DVL2 -0.45 -6.22 -0.32 1.55e-9 Protein C levels; CRC cis rs6754311 0.731 rs3769005 chr2:136603366 C/G cg15123519 chr2:136567270 LCT 0.33 6.39 0.33 5.65e-10 Mosquito bite size; CRC cis rs12701220 0.655 rs7784403 chr7:1153077 G/A cg26240231 chr7:1148101 C7orf50 -0.43 -6.34 -0.33 7.51e-10 Bronchopulmonary dysplasia; CRC cis rs10503871 1.000 rs10503872 chr8:30437031 C/G cg26383811 chr8:30366931 RBPMS -0.45 -7.3 -0.37 2.11e-12 Metabolite levels (X-11787); CRC cis rs9467711 0.606 rs2076030 chr6:26426856 G/A cg16898833 chr6:26189333 HIST1H4D 0.89 7.28 0.37 2.4e-12 Autism spectrum disorder or schizophrenia; CRC cis rs853679 0.517 rs9380049 chr6:28048535 A/G cg02631126 chr6:28058918 ZSCAN12L1 0.29 6.1 0.32 2.95e-9 Depression; CRC cis rs9768139 0.733 rs13309408 chr7:158122261 C/T cg25566285 chr7:158114605 PTPRN2 0.46 7.07 0.36 9.26e-12 Calcium levels; CRC cis rs1003719 0.751 rs56268364 chr21:38542765 C/T cg10648535 chr21:38446584 PIGP;TTC3 -0.48 -6.58 -0.34 1.83e-10 Eye color traits; CRC cis rs7666738 0.791 rs17549003 chr4:98969132 A/C cg17366294 chr4:99064904 C4orf37 0.42 7.21 0.37 3.76e-12 Colonoscopy-negative controls vs population controls; CRC cis rs910316 0.967 rs2024653 chr14:75595154 G/A cg03030879 chr14:75389066 RPS6KL1 -0.47 -7.43 -0.38 9.18e-13 Height; CRC cis rs290268 0.874 rs290995 chr9:93559477 C/A cg02608019 chr9:93564028 SYK 0.44 6.93 0.36 2.17e-11 Platelet count; CRC cis rs9296736 0.890 rs1325831 chr6:53904347 C/T cg04374786 chr6:53939321 C6orf142 -0.42 -6.5 -0.34 3.04e-10 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs12286929 0.644 rs9645660 chr11:115081563 C/T cg04055981 chr11:115044050 NA 0.39 6.24 0.33 1.37e-9 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs1355223 1.000 rs1396883 chr11:34757447 C/T cg11058730 chr11:34937778 PDHX;APIP -0.44 -6.22 -0.32 1.49e-9 Systemic lupus erythematosus and Systemic sclerosis; CRC cis rs4808199 0.948 rs968525 chr19:19459215 C/T cg03709012 chr19:19516395 GATAD2A 0.88 10.54 0.5 1.42e-22 Nonalcoholic fatty liver disease; CRC cis rs921968 0.643 rs600057 chr2:219456737 A/G cg02176678 chr2:219576539 TTLL4 0.48 8.02 0.4 1.82e-14 Mean corpuscular hemoglobin concentration; CRC cis rs9462846 0.802 rs1819324 chr6:42859723 G/C cg02353165 chr6:42928485 GNMT 0.47 6.5 0.34 2.95e-10 Blood protein levels; CRC cis rs58688157 0.660 rs12797496 chr11:583767 C/T cg16486109 chr11:613632 IRF7 0.72 11.75 0.54 7.45e-27 Systemic lupus erythematosus; CRC cis rs9911578 0.967 rs6503893 chr17:57149695 G/A cg05425664 chr17:57184151 TRIM37 -0.52 -8.17 -0.41 6.53e-15 Intelligence (multi-trait analysis); CRC cis rs8014671 0.597 rs8021180 chr14:70783943 A/G cg20409590 chr14:70655382 SLC8A3 -0.31 -6.21 -0.32 1.57e-9 Prostate cancer; CRC cis rs9916302 0.904 rs801426 chr17:37441109 C/T cg15445000 chr17:37608096 MED1 -0.39 -8.4 -0.42 1.37e-15 Glomerular filtration rate (creatinine); CRC cis rs751728 1.000 rs3806108 chr6:33767579 C/G cg11713064 chr6:33730089 NA 0.23 5.67 0.3 3.15e-8 Crohn's disease; CRC cis rs644799 1.000 rs12291986 chr11:95523030 T/G cg03916912 chr11:95522834 CEP57;FAM76B 0.96 18.3 0.71 4.39e-52 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs117623576 0.941 rs72778753 chr10:32426579 A/T cg03047570 chr10:32398778 NA -0.69 -7.39 -0.38 1.19e-12 Anti-saccade response; CRC cis rs12711979 0.509 rs10192699 chr2:3824297 A/G cg17052675 chr2:3827356 NA -0.86 -21.11 -0.76 3.77e-63 Itch intensity from mosquito bite adjusted by bite size; CRC cis rs7666738 0.830 rs7657982 chr4:99044015 G/A cg05340658 chr4:99064831 C4orf37 0.6 9.37 0.46 1.23e-18 Colonoscopy-negative controls vs population controls; CRC cis rs3750082 0.582 rs3750079 chr7:32969419 G/A cg05721444 chr7:32995514 FKBP9 0.61 8.79 0.44 8.64e-17 Glomerular filtration rate (creatinine); CRC cis rs7786808 0.741 rs11769149 chr7:158227127 A/G cg15440763 chr7:158190612 PTPRN2 -0.39 -6.06 -0.32 3.72e-9 Obesity-related traits; CRC cis rs6952808 0.531 rs3779002 chr7:2183219 C/T cg21782813 chr7:2030301 MAD1L1 0.49 8.29 0.42 2.96e-15 Bipolar disorder and schizophrenia; CRC cis rs6963495 0.818 rs818619 chr7:105172505 A/T cg02135003 chr7:105160482 PUS7 -0.68 -10.13 -0.49 3.59e-21 Bipolar disorder (body mass index interaction); CRC cis rs250677 0.652 rs250675 chr5:148438565 A/C cg23229984 chr5:148520753 ABLIM3 -0.5 -6.92 -0.36 2.32e-11 Breast cancer; CRC cis rs801193 0.569 rs6951302 chr7:66132512 T/C cg00343986 chr7:65444356 GUSB -0.45 -6.2 -0.32 1.7e-9 Aortic root size; CRC cis rs3823572 0.564 rs2346275 chr7:133662166 G/A cg03336402 chr7:133662267 EXOC4 -0.67 -10.62 -0.51 7.59e-23 Intelligence (multi-trait analysis); CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg01821126 chr16:70100199 PDXDC2 0.46 6.41 0.33 5.12e-10 Anxiety disorder; CRC cis rs738322 0.967 rs133024 chr22:38574066 C/T cg25457927 chr22:38595422 NA 0.37 7.82 0.4 7.03e-14 Cutaneous nevi; CRC trans rs855408 0.883 rs208990 chr6:62864433 A/G cg21737066 chr3:72495901 RYBP 0.5 6.06 0.32 3.77e-9 Epstein-Barr virus copy number in lymphoblastoid cell lines; CRC cis rs853679 0.517 rs9393893 chr6:28109262 T/C cg25164649 chr6:28176230 NA 0.78 9.66 0.47 1.33e-19 Depression; CRC cis rs4862750 0.874 rs6553027 chr4:187875777 T/C cg10295955 chr4:187884368 NA -1.01 -23.38 -0.79 6.57e-72 Lobe attachment (rater-scored or self-reported); CRC trans rs9291683 0.588 rs4280729 chr4:10013861 C/T cg26043149 chr18:55253948 FECH 0.54 8.53 0.43 5.51e-16 Bone mineral density; CRC cis rs911186 0.947 rs9379962 chr6:27145311 C/T cg12292205 chr6:26970375 C6orf41 -0.67 -8.19 -0.41 5.9e-15 Autism spectrum disorder or schizophrenia; CRC cis rs216303 0.642 rs216335 chr12:6148005 T/C cg19878637 chr12:6148451 VWF -0.63 -6.91 -0.36 2.54e-11 Low vWF levels; CRC cis rs6088813 0.885 rs6142353 chr20:33942685 G/A cg14752227 chr20:34000481 UQCC -0.37 -5.73 -0.3 2.3e-8 Height; CRC trans rs4942242 0.763 rs7326281 chr13:44233186 G/A cg26741380 chr15:41871084 TYRO3 -0.48 -7.08 -0.36 8.85e-12 Response to tocilizumab in rheumatoid arthritis; CRC cis rs7572644 0.699 rs6738887 chr2:28268467 C/T cg27432699 chr2:27873401 GPN1 -0.41 -5.71 -0.3 2.51e-8 Response to carboplatin and paclitaxel in ovarian cancer (Caspase 3/7 EC50); CRC cis rs889312 0.500 rs252906 chr5:56119190 G/T cg20203395 chr5:56204925 C5orf35 -0.44 -6.13 -0.32 2.54e-9 Breast cancer;Breast cancer (early onset); CRC cis rs2836950 0.501 rs35994303 chr21:40686020 C/T cg11890956 chr21:40555474 PSMG1 -0.62 -8.9 -0.44 3.86e-17 Menarche (age at onset); CRC cis rs10504229 0.683 rs16921823 chr8:58108612 G/C cg24829409 chr8:58192753 C8orf71 -0.56 -7.95 -0.4 3.02e-14 Developmental language disorder (linguistic errors); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg15345369 chr2:10262827 RRM2 0.37 6.19 0.32 1.79e-9 Liver disease severity in Alagille syndrome; CRC cis rs6951245 1.000 rs6951245 chr7:1058193 G/A cg26224354 chr7:1096374 C7orf50;GPR146 -0.87 -10.98 -0.52 4.04e-24 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs67311347 1.000 rs4571217 chr3:40521973 A/G cg24209194 chr3:40518798 ZNF619 0.41 6.03 0.32 4.45e-9 Renal cell carcinoma; CRC cis rs2549003 1.000 rs2070722 chr5:131824486 A/C cg02551604 chr5:131831745 NA -0.56 -8.78 -0.44 8.88e-17 Asthma (sex interaction); CRC cis rs8005677 1.000 rs1956881 chr14:23394069 A/C cg01529538 chr14:23388837 RBM23 0.4 6.18 0.32 1.9e-9 Cognitive ability (multi-trait analysis); CRC cis rs6502050 0.835 rs62078305 chr17:80085326 G/A cg13198984 chr17:80129470 CCDC57 -0.48 -8.56 -0.43 4.49e-16 Life satisfaction; CRC cis rs1448094 0.511 rs10746353 chr12:86150146 A/T cg02569458 chr12:86230093 RASSF9 -0.48 -8.08 -0.41 1.27e-14 Major depressive disorder; CRC cis rs2032447 0.670 rs198848 chr6:26106325 A/G cg03264133 chr6:25882463 NA -0.41 -5.69 -0.3 2.84e-8 Intelligence (multi-trait analysis); CRC cis rs763121 0.853 rs138716 chr22:39146527 C/T cg06544989 chr22:39130855 UNC84B 0.45 6.5 0.34 2.91e-10 Menopause (age at onset); CRC cis rs6570726 0.846 rs9376954 chr6:145943737 T/A cg23711669 chr6:146136114 FBXO30 0.64 10.62 0.51 7.3e-23 Lobe attachment (rater-scored or self-reported); CRC cis rs11758351 0.866 rs77889957 chr6:26207435 A/G cg01420254 chr6:26195488 NA 0.78 8.99 0.44 1.96e-17 Gout;Renal underexcretion gout; CRC cis rs651907 0.513 rs34963630 chr3:101504817 C/T cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.56 7.37 0.38 1.41e-12 Colorectal cancer; CRC cis rs919433 0.713 rs11900232 chr2:198466273 T/C cg10820045 chr2:198174542 NA 0.41 7.1 0.36 7.61e-12 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC cis rs9858542 0.903 rs17080528 chr3:49389842 C/T cg07274523 chr3:49395745 GPX1 0.45 6.01 0.31 4.82e-9 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs7258465 1.000 rs10403249 chr19:18604942 T/C cg10790698 chr19:18539756 SSBP4 -0.44 -8.44 -0.42 1e-15 Breast cancer; CRC cis rs1799949 0.965 rs33925201 chr17:41280682 A/G cg01879757 chr17:41196368 BRCA1 -0.43 -6.58 -0.34 1.86e-10 Menopause (age at onset); CRC cis rs6968419 0.755 rs4710 chr7:115897392 G/C cg02561103 chr7:115862891 TES -0.43 -6.44 -0.33 4.17e-10 Intraocular pressure; CRC cis rs908922 0.676 rs1856120 chr1:152512441 G/A cg23254163 chr1:152506842 NA 0.45 8.85 0.44 5.3e-17 Hair morphology; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg21551185 chr12:65950729 NA 0.39 6.35 0.33 7.25e-10 Intelligence (multi-trait analysis); CRC cis rs7727544 1.000 rs7727544 chr5:131590534 C/T cg22638593 chr5:131593259 PDLIM4 0.37 7.07 0.36 9.45e-12 Blood metabolite levels; CRC cis rs2882667 0.898 rs6890272 chr5:138371116 G/A cg09476006 chr5:138032270 NA 0.44 7.41 0.38 1.09e-12 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs7493 0.853 rs6973380 chr7:95043523 C/T cg21856205 chr7:94953877 PON1 -0.49 -6.55 -0.34 2.18e-10 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs4819052 0.851 rs2838834 chr21:46665208 C/T cg19498844 chr21:46707878 POFUT2;LOC642852 0.81 12.08 0.55 4.54e-28 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC trans rs11148252 0.595 rs9526968 chr13:53240183 T/C cg18335740 chr13:41363409 SLC25A15 0.75 13.62 0.6 8.5e-34 Lewy body disease; CRC cis rs370915 0.507 rs6835018 chr4:187794328 C/A cg12892747 chr4:187813459 NA -0.56 -8.05 -0.41 1.5e-14 Gout; CRC cis rs7208859 0.623 rs77009951 chr17:29080650 T/C cg13385521 chr17:29058706 SUZ12P 0.72 8.24 0.41 4.19e-15 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg17772535 chr12:65153236 GNS 0.43 6.97 0.36 1.77e-11 Liver disease severity in Alagille syndrome; CRC cis rs4862750 0.794 rs1030382 chr4:187903782 T/G cg22105103 chr4:187893119 NA 0.68 12.3 0.56 7.28e-29 Lobe attachment (rater-scored or self-reported); CRC cis rs7113874 0.569 rs7131358 chr11:8558333 G/C cg17679104 chr11:8615758 STK33 -0.36 -5.96 -0.31 6.35e-9 Body mass index in physically active individuals;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs6570726 0.791 rs401331 chr6:145831408 A/G cg05347473 chr6:146136440 FBXO30 0.41 6.28 0.33 1.04e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs7666738 0.830 rs921523 chr4:98841659 C/T cg17366294 chr4:99064904 C4orf37 0.38 6.06 0.32 3.83e-9 Colonoscopy-negative controls vs population controls; CRC cis rs1552244 0.938 rs7625049 chr3:10115619 C/T cg16606324 chr3:10149918 C3orf24 0.7 9.66 0.47 1.31e-19 Alzheimer's disease; CRC cis rs6860806 0.507 rs635619 chr5:131720265 G/A cg02033258 chr5:131593261 PDLIM4 -0.39 -6.61 -0.34 1.52e-10 Breast cancer; CRC cis rs12630931 0.798 rs4073767 chr3:31988108 G/A cg21375017 chr3:31988082 OSBPL10 0.49 6.28 0.33 1.05e-9 Periodontal disease-related phenotypes; CRC trans rs2243480 1.000 rs316312 chr7:65596491 T/G cg10756647 chr7:56101905 PSPH 0.74 7.74 0.39 1.23e-13 Diabetic kidney disease; CRC cis rs9611565 0.694 rs202641 chr22:41833116 C/T cg06634786 chr22:41940651 POLR3H 0.53 6.5 0.34 2.93e-10 Vitiligo; CRC cis rs6121246 0.529 rs6060134 chr20:30176794 A/G cg13852791 chr20:30311386 BCL2L1 0.6 8.0 0.4 2.15e-14 Mean corpuscular hemoglobin; CRC cis rs5769765 0.825 rs7511620 chr22:50307932 T/C cg02269571 chr22:50332266 NA -0.59 -7.94 -0.4 3.21e-14 Schizophrenia; CRC cis rs7940866 0.834 rs10791108 chr11:130849354 T/A cg12179176 chr11:130786555 SNX19 0.59 8.57 0.43 3.97e-16 Schizophrenia; CRC cis rs8072100 0.870 rs10432035 chr17:45624913 G/C cg25173405 chr17:45401733 C17orf57 0.44 6.74 0.35 6.94e-11 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs7520050 0.553 rs2993263 chr1:46021630 A/G cg24296786 chr1:45957014 TESK2 -0.46 -6.49 -0.34 3.17e-10 Red blood cell count;Reticulocyte count; CRC cis rs7615952 0.599 rs16834938 chr3:125706046 C/T cg02807482 chr3:125708958 NA -0.44 -5.8 -0.3 1.55e-8 Blood pressure (smoking interaction); CRC cis rs7692995 1.000 rs6842114 chr4:18008199 A/C cg08925142 chr4:18023851 LCORL -0.53 -5.98 -0.31 5.78e-9 Height; CRC cis rs11958404 0.932 rs72816579 chr5:157431877 T/C cg05962755 chr5:157440814 NA 1.01 12.88 0.58 5.12e-31 IgG glycosylation; CRC cis rs35146811 0.735 rs11764176 chr7:99786964 G/T cg13334819 chr7:99746414 C7orf59 -0.51 -6.72 -0.35 7.79e-11 Coronary artery disease; CRC cis rs4294134 0.832 rs12707241 chr7:135259183 T/C cg20392616 chr7:135392013 SLC13A4 0.51 5.78 0.3 1.71e-8 Paget's disease; CRC cis rs1348850 0.668 rs4893972 chr2:178496874 T/C cg22681709 chr2:178499509 PDE11A -0.35 -5.9 -0.31 8.79e-9 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs9527 0.668 rs7092815 chr10:104736345 G/T cg15744005 chr10:104629667 AS3MT -0.31 -6.0 -0.31 5.31e-9 Arsenic metabolism; CRC cis rs9309711 0.544 rs9309712 chr2:3491327 G/T cg15506890 chr2:3487001 NA -0.56 -9.01 -0.45 1.67e-17 Neurofibrillary tangles; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg22194305 chr4:2264032 MXD4 0.51 7.43 0.38 9.16e-13 Response to antipsychotic treatment; CRC trans rs2303319 0.582 rs16845851 chr2:162295623 A/C cg04145477 chr6:107077629 RTN4IP1;QRSL1 -0.84 -6.23 -0.32 1.43e-9 Cognitive function; CRC cis rs6504622 0.537 rs1662597 chr17:44994855 T/C cg16759221 chr17:45003025 GOSR2 -0.65 -10.52 -0.5 1.62e-22 Orofacial clefts; CRC cis rs736408 0.509 rs3774349 chr3:52722335 A/C cg10802521 chr3:52805072 NEK4 -0.49 -7.67 -0.39 1.96e-13 Bipolar disorder; CRC cis rs2204008 0.805 rs11169513 chr12:37988640 G/A cg26384229 chr12:38710491 ALG10B 0.69 9.18 0.45 5.02e-18 Bladder cancer; CRC cis rs28830936 1.000 rs28830936 chr15:41906408 G/A cg17847044 chr15:42102381 MAPKBP1 -0.29 -6.1 -0.32 2.9e-9 Diastolic blood pressure; CRC cis rs6502050 0.835 rs6502079 chr17:80124454 T/A cg09264619 chr17:80180166 NA -0.35 -5.93 -0.31 7.47e-9 Life satisfaction; CRC cis rs7927592 0.913 rs4988291 chr11:68381607 G/A cg01657329 chr11:68192670 LRP5 -0.46 -6.61 -0.34 1.51e-10 Total body bone mineral density; CRC cis rs561341 1.000 rs15654 chr17:30326360 A/C cg12193833 chr17:30244370 NA -0.76 -8.87 -0.44 4.62e-17 Hip circumference adjusted for BMI; CRC cis rs546131 0.928 rs572690 chr11:34833614 A/G cg06937548 chr11:34938143 PDHX;APIP 0.42 6.24 0.33 1.33e-9 Lung disease severity in cystic fibrosis; CRC cis rs10979 0.651 rs9321921 chr6:143895053 C/T cg25407410 chr6:143891975 LOC285740 -0.7 -9.94 -0.48 1.59e-20 Hypospadias; CRC cis rs9341808 0.618 rs6916507 chr6:80862265 T/C cg08355045 chr6:80787529 NA 0.42 6.92 0.36 2.41e-11 Sitting height ratio; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg26797661 chr1:151138516 LYSMD1;SCNM1 0.4 6.15 0.32 2.31e-9 Intelligence (multi-trait analysis); CRC cis rs4713118 0.869 rs9295742 chr6:27702832 G/A cg20933634 chr6:27740509 NA 0.58 8.5 0.42 6.74e-16 Parkinson's disease; CRC cis rs7208859 0.623 rs55638872 chr17:29149552 G/C cg13385521 chr17:29058706 SUZ12P 0.74 8.22 0.41 4.85e-15 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs9311474 0.508 rs12629701 chr3:52619836 T/C cg18404041 chr3:52824283 ITIH1 -0.41 -8.55 -0.43 4.83e-16 Electroencephalogram traits; CRC cis rs853679 0.517 rs9357063 chr6:28060005 G/A cg15845792 chr6:28175446 NA 0.98 13.02 0.58 1.56e-31 Depression; CRC cis rs941898 0.836 rs8016001 chr14:100598691 A/G cg26002632 chr14:100625216 DEGS2 -0.39 -5.92 -0.31 8.31e-9 White matter hyperintensity burden; CRC cis rs9486719 0.843 rs976357 chr6:96849679 C/T cg06623918 chr6:96969491 KIAA0776 0.79 8.48 0.42 7.89e-16 Migraine;Coronary artery disease; CRC cis rs9916302 0.861 rs10491129 chr17:37461643 T/G cg03013999 chr17:37608204 MED1 -0.48 -7.46 -0.38 7.7e-13 Glomerular filtration rate (creatinine); CRC cis rs6860806 0.695 rs11952099 chr5:131576772 A/G cg02033258 chr5:131593261 PDLIM4 0.41 7.89 0.4 4.58e-14 Breast cancer; CRC trans rs11098499 0.789 rs12498994 chr4:120250818 A/C cg25214090 chr10:38739885 LOC399744 0.53 8.36 0.42 1.81e-15 Corneal astigmatism; CRC cis rs6693567 0.874 rs698915 chr1:150388318 C/T cg04165759 chr1:150448943 RPRD2 -0.37 -5.71 -0.3 2.58e-8 Migraine; CRC cis rs10751667 0.677 rs9794921 chr11:1039867 T/G ch.11.42038R chr11:967971 AP2A2 0.54 7.1 0.36 7.87e-12 Alzheimer's disease (late onset); CRC trans rs10504229 1.000 rs67913746 chr8:58177825 A/G cg04077850 chr5:125800366 GRAMD3 0.37 6.27 0.33 1.15e-9 Developmental language disorder (linguistic errors); CRC cis rs1150668 0.699 rs2394049 chr6:28239681 A/G cg03623178 chr6:28175578 NA 0.5 7.4 0.38 1.15e-12 Pubertal anthropometrics; CRC cis rs711830 1.000 rs2857540 chr2:177026698 G/T cg13092806 chr2:177043255 NA 0.71 8.42 0.42 1.15e-15 Serous invasive ovarian cancer;Epithelial ovarian cancer;Invasive epithelial ovarian cancer;Mucinous ovarian carcinoma;Low-grade serous and serous borderline ovarian cancer;Serous borderline ovarian cancer;High-grade serous ovarian cancer; CRC trans rs459571 0.920 rs433402 chr9:136898627 A/G cg15028160 chr19:49622717 PPFIA3;C19orf73 -0.55 -6.61 -0.34 1.58e-10 Platelet distribution width; CRC cis rs7666738 0.830 rs13130923 chr4:99046281 T/C cg05340658 chr4:99064831 C4orf37 0.6 9.35 0.46 1.4e-18 Colonoscopy-negative controls vs population controls; CRC cis rs5997397 0.967 rs5762777 chr22:29150044 T/C cg15103426 chr22:29168792 CCDC117 0.39 5.73 0.3 2.21e-8 Red cell distribution width; CRC cis rs10504229 0.683 rs10504223 chr8:58140944 G/A cg22535103 chr8:58192502 C8orf71 -0.7 -9.34 -0.46 1.47e-18 Developmental language disorder (linguistic errors); CRC cis rs1552244 1.000 rs7622963 chr3:10139825 C/T cg18598329 chr3:10140678 FANCD2;C3orf24 -0.9 -13.24 -0.59 2.25e-32 Alzheimer's disease; CRC cis rs11098499 0.954 rs4345162 chr4:120312959 G/A cg09307838 chr4:120376055 NA 0.71 10.93 0.52 6.41e-24 Corneal astigmatism; CRC cis rs2842992 0.958 rs2758318 chr6:160069637 C/G cg16489826 chr6:160211363 TCP1;MRPL18 0.49 6.42 0.33 4.81e-10 Age-related macular degeneration (geographic atrophy); CRC cis rs6951245 1.000 rs78185558 chr7:1090183 G/C cg08132940 chr7:1081526 C7orf50 -0.54 -5.93 -0.31 7.59e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs853679 0.517 rs9348793 chr6:28084189 G/A cg21251018 chr6:28226885 NKAPL 0.48 6.19 0.32 1.84e-9 Depression; CRC cis rs875971 0.862 rs17747530 chr7:65994729 G/C cg12463550 chr7:65579703 CRCP 0.47 6.45 0.33 4.03e-10 Aortic root size; CRC cis rs1707322 0.685 rs6690926 chr1:46134978 T/C cg06784218 chr1:46089804 CCDC17 0.66 12.35 0.56 4.77e-29 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs3741404 0.895 rs1860368 chr11:63994692 T/C cg05016508 chr11:63871570 FLRT1;MACROD1 -0.44 -6.82 -0.35 4.25e-11 Platelet count; CRC cis rs10464366 0.746 rs62442210 chr7:39146328 G/T cg18850127 chr7:39170497 POU6F2 0.53 6.82 0.35 4.29e-11 IgG glycosylation; CRC cis rs1552244 0.572 rs57268864 chr3:10164233 C/A cg10729496 chr3:10149963 C3orf24 0.48 5.61 0.3 4.19e-8 Alzheimer's disease; CRC cis rs311392 0.867 rs367108 chr8:55093142 G/A cg20636351 chr8:55087400 NA -0.33 -5.96 -0.31 6.62e-9 Pelvic organ prolapse (moderate/severe); CRC cis rs11190604 1.000 rs10883505 chr10:102280772 C/T cg16342193 chr10:102329863 NA -0.37 -6.0 -0.31 5.28e-9 Palmitoleic acid (16:1n-7) levels; CRC cis rs734999 0.545 rs28532547 chr1:2561286 T/G cg20673091 chr1:2541236 MMEL1 -0.37 -6.02 -0.32 4.56e-9 Ulcerative colitis; CRC cis rs4713118 0.513 rs149944 chr6:28002818 C/T cg02631126 chr6:28058918 ZSCAN12L1 0.23 5.62 0.3 4.16e-8 Parkinson's disease; CRC trans rs561341 0.830 rs2301765 chr17:30202056 T/A cg27661571 chr11:113659931 NA 0.65 7.59 0.39 3.3e-13 Hip circumference adjusted for BMI; CRC cis rs7546094 1.000 rs1001494 chr1:113110619 T/C cg22162597 chr1:113214053 CAPZA1 0.43 5.94 0.31 7.2e-9 Platelet distribution width; CRC cis rs9894429 0.608 rs7406219 chr17:79609410 G/T cg09655341 chr17:79618100 PDE6G -0.36 -6.13 -0.32 2.53e-9 Eye color traits; CRC cis rs7487075 1.000 rs10880966 chr12:46801782 C/G cg22049899 chr12:47219821 SLC38A4 0.33 6.53 0.34 2.53e-10 Itch intensity from mosquito bite; CRC cis rs6570726 0.935 rs401888 chr6:145831535 A/G cg23711669 chr6:146136114 FBXO30 0.68 12.16 0.56 2.33e-28 Lobe attachment (rater-scored or self-reported); CRC cis rs7666738 1.000 rs13116475 chr4:99054843 C/T cg03676636 chr4:99064102 C4orf37 -0.22 -6.14 -0.32 2.33e-9 Colonoscopy-negative controls vs population controls; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg04277470 chr13:41707106 KBTBD6 0.46 6.4 0.33 5.4e-10 Response to antipsychotic treatment; CRC cis rs428668 0.523 rs6898671 chr5:150677643 A/T cg11125805 chr5:150678162 SLC36A3 0.63 12.16 0.56 2.42e-28 Skin aging (microtopography measurement); CRC cis rs3806843 0.838 rs2262567 chr5:140132134 T/A cg16607685 chr5:140181889 PCDHA2;PCDHA1;PCDHA3 0.26 5.93 0.31 7.73e-9 Depressive symptoms (multi-trait analysis); CRC cis rs703842 1.000 rs11172344 chr12:58193448 T/C cg00677455 chr12:58241039 CTDSP2 0.67 9.42 0.46 8.41e-19 Multiple sclerosis; CRC cis rs9926296 0.527 rs1800335 chr16:89846195 A/G cg21285383 chr16:89894308 SPIRE2 0.36 6.2 0.32 1.71e-9 Vitiligo; CRC cis rs3785574 0.962 rs2584632 chr17:61880641 G/A cg06601766 chr17:61851465 DDX42;CCDC47 0.61 8.68 0.43 1.83e-16 Height; CRC trans rs12478296 0.901 rs7420176 chr2:243005277 G/A cg18288967 chr1:45987694 PRDX1 0.65 7.77 0.39 1.03e-13 Obesity-related traits; CRC cis rs13256369 0.851 rs11249890 chr8:8565245 G/T cg06671706 chr8:8559999 CLDN23 0.62 9.05 0.45 1.3e-17 Obesity-related traits; CRC trans rs13046373 0.905 rs4816372 chr21:32077414 A/T cg17956387 chr1:208418015 PLXNA2 -0.39 -5.96 -0.31 6.35e-9 HDL cholesterol; CRC cis rs897984 0.762 rs4889604 chr16:30985994 G/T cg02466173 chr16:30829666 NA 0.61 9.0 0.44 1.87e-17 Dementia with Lewy bodies; CRC cis rs17711722 0.522 rs62469933 chr7:65265639 G/A cg00343986 chr7:65444356 GUSB 0.48 7.0 0.36 1.48e-11 Calcium levels; CRC cis rs1348850 0.632 rs10167783 chr2:178519041 G/A cg02961200 chr2:178257176 LOC100130691;AGPS 0.63 8.77 0.44 9.58e-17 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs9457247 1.000 rs400176 chr6:167406238 T/C cg23791538 chr6:167370224 RNASET2 -0.38 -5.94 -0.31 7.32e-9 Crohn's disease; CRC cis rs3096299 0.685 rs4785676 chr16:89553624 T/C cg00750074 chr16:89608354 SPG7 -0.5 -7.59 -0.39 3.29e-13 Multiple myeloma (IgH translocation); CRC cis rs7914558 0.902 rs7092200 chr10:104844872 T/C cg11453585 chr10:104263688 ACTR1A;SUFU -0.39 -5.72 -0.3 2.41e-8 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs1401999 0.898 rs4148564 chr3:183725982 C/T cg01324343 chr3:183735012 ABCC5 0.8 14.75 0.63 3.65e-38 Anterior chamber depth; CRC cis rs11864453 0.713 rs8051882 chr16:72142072 A/G cg01557791 chr16:72042693 DHODH 0.45 6.31 0.33 9.01e-10 Fibrinogen levels; CRC cis rs6951245 0.938 rs11764937 chr7:1092074 C/T cg07217954 chr7:1067459 C7orf50 0.57 5.98 0.31 5.73e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs2115630 1.000 rs7183401 chr15:85371944 G/T cg12501888 chr15:85177176 SCAND2 -0.37 -6.16 -0.32 2.09e-9 P wave terminal force; CRC cis rs79387448 0.810 rs75218113 chr2:103239356 C/G cg00507830 chr2:103233733 NA 0.73 7.57 0.39 3.71e-13 Gut microbiota (bacterial taxa); CRC cis rs9916302 0.706 rs801427 chr17:37436711 A/G cg00129232 chr17:37814104 STARD3 -0.56 -6.97 -0.36 1.77e-11 Glomerular filtration rate (creatinine); CRC cis rs7927771 0.524 rs10838732 chr11:47607940 C/G cg20307385 chr11:47447363 PSMC3 0.51 7.6 0.39 3.1e-13 Subjective well-being; CRC cis rs6748734 1.000 rs6751693 chr2:241837332 T/C cg07537917 chr2:241836409 C2orf54 -0.21 -5.7 -0.3 2.65e-8 Urinary metabolites; CRC cis rs10504229 0.683 rs7827014 chr8:58132230 G/A cg21724239 chr8:58056113 NA 0.49 6.81 0.35 4.75e-11 Developmental language disorder (linguistic errors); CRC trans rs10983614 1.000 rs7867776 chr9:120072627 A/G cg11147586 chr5:170845829 FGF18 0.45 6.08 0.32 3.25e-9 Survival in pancreatic cancer; CRC cis rs758970 0.523 rs741028 chr9:129186589 C/G cg15282417 chr9:129245246 FAM125B -0.35 -6.07 -0.32 3.59e-9 Obesity-related traits; CRC cis rs3087591 0.636 rs736598 chr17:29720470 T/C cg24425628 chr17:29625626 OMG;NF1 0.71 13.05 0.58 1.18e-31 Hip circumference; CRC cis rs1862618 0.627 rs744023 chr5:56197078 C/T cg22800045 chr5:56110881 MAP3K1 0.58 5.7 0.3 2.7e-8 Initial pursuit acceleration; CRC cis rs6598955 0.670 rs10902734 chr1:26617923 G/T cg04990556 chr1:26633338 UBXN11 0.79 13.09 0.59 8.5e-32 Obesity-related traits; CRC cis rs11229555 0.645 rs12802819 chr11:58174747 T/G cg15696309 chr11:58395628 NA -0.81 -10.38 -0.5 5.2e-22 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; CRC cis rs67311347 0.713 rs9861194 chr3:40309225 C/T cg09455208 chr3:40491958 NA 0.34 6.93 0.36 2.26e-11 Renal cell carcinoma; CRC cis rs2230307 0.536 rs640030 chr1:100574992 C/T cg24955406 chr1:100503596 HIAT1 -0.56 -6.7 -0.35 9.25e-11 Carotid intima media thickness; CRC cis rs3790455 0.610 rs3790458 chr1:156459699 A/T cg14087168 chr1:156450669 MEF2D -0.37 -6.54 -0.34 2.3e-10 Migraine; CRC cis rs9902453 1.000 rs56280226 chr17:28429575 T/C cg26525008 chr17:28256777 EFCAB5;SSH2 0.59 8.92 0.44 3.23e-17 Coffee consumption (cups per day); CRC cis rs9303401 0.592 rs12936771 chr17:56725052 T/C cg10487724 chr17:56770010 TEX14;RAD51C 0.78 9.69 0.47 1.07e-19 Cognitive test performance; CRC trans rs11098499 0.569 rs55845118 chr4:120290913 T/C cg25214090 chr10:38739885 LOC399744 0.61 9.66 0.47 1.39e-19 Corneal astigmatism; CRC cis rs7937682 0.889 rs1789359 chr11:111475995 T/A cg19812747 chr11:111475976 SIK2 -0.59 -10.14 -0.49 3.31e-21 Primary sclerosing cholangitis; CRC cis rs875971 0.767 rs1643394 chr7:65836094 A/G cg12463550 chr7:65579703 CRCP 0.51 7.19 0.37 4.36e-12 Aortic root size; CRC cis rs877282 1.000 rs12773872 chr10:771939 T/C cg06581033 chr10:766294 NA -0.5 -5.76 -0.3 1.93e-8 Uric acid levels; CRC trans rs11148252 0.538 rs2408609 chr13:52714043 C/T cg18335740 chr13:41363409 SLC25A15 0.53 7.89 0.4 4.58e-14 Lewy body disease; CRC cis rs6502050 0.749 rs7406163 chr17:80086389 C/T cg25804541 chr17:80189381 SLC16A3 0.31 6.01 0.31 4.97e-9 Life satisfaction; CRC cis rs561341 0.609 rs2051810 chr17:30195841 C/T cg13647721 chr17:30228624 UTP6 -0.62 -7.18 -0.37 4.64e-12 Hip circumference adjusted for BMI; CRC cis rs6500602 0.673 rs1861652 chr16:4505331 C/T cg06139259 chr16:4526053 HMOX2;NMRAL1 0.41 5.66 0.3 3.32e-8 Schizophrenia; CRC cis rs2153535 0.580 rs2327057 chr6:8443319 G/A cg21535247 chr6:8435926 SLC35B3 0.47 7.12 0.37 6.79e-12 Motion sickness; CRC cis rs2227564 0.678 rs2242257 chr10:75597605 A/G cg00564723 chr10:75632066 CAMK2G 0.37 8.65 0.43 2.34e-16 Crohn's disease;Inflammatory bowel disease; CRC cis rs7666738 0.830 rs17026973 chr4:98680041 T/A cg17366294 chr4:99064904 C4orf37 0.35 5.7 0.3 2.66e-8 Colonoscopy-negative controls vs population controls; CRC cis rs875971 0.522 rs10807697 chr7:65416170 A/G cg18876405 chr7:65276391 NA 0.67 12.13 0.56 3.12e-28 Aortic root size; CRC trans rs1455244 0.700 rs7229302 chr18:11508904 G/T cg10162261 chr22:38598048 MAFF 0.39 6.24 0.33 1.34e-9 Schizophrenia; CRC trans rs1814175 0.817 rs10839401 chr11:49876144 C/T cg03929089 chr4:120376271 NA -0.93 -17.64 -0.7 1.77e-49 Height; CRC cis rs7772486 0.790 rs2247429 chr6:146217769 T/C cg23711669 chr6:146136114 FBXO30 0.72 12.75 0.57 1.61e-30 Lobe attachment (rater-scored or self-reported); CRC cis rs75920871 0.588 rs4620758 chr11:116945718 G/A cg01368799 chr11:117014884 PAFAH1B2 -0.43 -5.91 -0.31 8.64e-9 Subjective well-being; CRC cis rs10504229 1.000 rs117231141 chr8:58185465 A/G cg05313129 chr8:58192883 C8orf71 -0.47 -6.99 -0.36 1.49e-11 Developmental language disorder (linguistic errors); CRC cis rs16867321 0.853 rs58388320 chr2:181340490 C/T cg23363182 chr2:181467187 NA -0.51 -5.98 -0.31 5.76e-9 Obesity; CRC trans rs9329221 0.506 rs6993610 chr8:10330994 C/G cg06636001 chr8:8085503 FLJ10661 -0.5 -7.43 -0.38 9.25e-13 Neuroticism; CRC trans rs208520 0.661 rs207099 chr6:66796373 A/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.07 -15.42 -0.65 9.24e-41 Exhaled nitric oxide output; CRC cis rs9486719 0.947 rs9386648 chr6:97035656 T/C cg18709589 chr6:96969512 KIAA0776 -0.52 -5.83 -0.31 1.3e-8 Migraine;Coronary artery disease; CRC cis rs4664293 0.631 rs6714899 chr2:160449406 A/G cg08347373 chr2:160653686 CD302 -0.39 -6.49 -0.34 3.11e-10 Monocyte percentage of white cells; CRC cis rs916888 0.779 rs430685 chr17:44859148 T/C cg15921436 chr17:44337874 NA -0.68 -7.81 -0.4 7.78e-14 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs12220238 1.000 rs10824098 chr10:75943579 C/T cg19889307 chr10:75911429 ADK;AP3M1 0.57 5.78 0.3 1.73e-8 Soluble interleukin-2 receptor subunit alpha; CRC cis rs2839186 0.587 rs35679325 chr21:47640980 A/G cg12516959 chr21:47718080 NA 0.35 5.96 0.31 6.46e-9 Testicular germ cell tumor; CRC cis rs6964587 0.626 rs4729014 chr7:91550707 A/G cg17063962 chr7:91808500 NA -0.6 -9.6 -0.47 2.04e-19 Breast cancer; CRC cis rs2179367 0.959 rs540538 chr6:149647944 C/T cg07828024 chr6:149772892 ZC3H12D -0.38 -6.08 -0.32 3.27e-9 Dupuytren's disease; CRC cis rs853679 0.599 rs149943 chr6:28002388 G/A cg15786705 chr6:28176104 NA 0.67 6.36 0.33 6.67e-10 Depression; CRC cis rs7605827 0.675 rs2111449 chr2:15616215 C/T cg19274914 chr2:15703543 NA 0.39 5.64 0.3 3.6e-8 Educational attainment (years of education); CRC cis rs881375 0.933 rs10818485 chr9:123667816 G/C cg00246817 chr9:123691163 NA -0.47 -6.04 -0.32 4.11e-9 Rheumatoid arthritis; CRC cis rs1153858 1.000 rs12593370 chr15:45617417 C/T cg10760299 chr15:45669010 GATM 0.53 8.09 0.41 1.14e-14 Homoarginine levels; CRC cis rs9733 0.744 rs12568757 chr1:150729793 C/T cg17724175 chr1:150552817 MCL1 -0.38 -5.77 -0.3 1.8e-8 Tonsillectomy; CRC cis rs4144743 0.759 rs16941731 chr17:45317022 C/T cg18085866 chr17:45331354 ITGB3 0.55 6.43 0.33 4.42e-10 Body mass index; CRC cis rs1044826 0.642 rs432387 chr3:139231853 T/G cg00490450 chr3:139108681 COPB2 -0.43 -6.41 -0.33 4.94e-10 Obesity-related traits; CRC cis rs7772486 0.754 rs1055212 chr6:146058315 A/T cg13319975 chr6:146136371 FBXO30 0.44 6.53 0.34 2.44e-10 Lobe attachment (rater-scored or self-reported); CRC cis rs11098499 0.863 rs3822192 chr4:120445720 A/C cg24375607 chr4:120327624 NA 0.5 7.51 0.38 5.75e-13 Corneal astigmatism; CRC cis rs877282 0.891 rs11253393 chr10:788824 G/T cg17470449 chr10:769945 NA 0.69 9.03 0.45 1.51e-17 Uric acid levels; CRC cis rs10504229 0.953 rs67677367 chr8:58175264 T/G cg05313129 chr8:58192883 C8orf71 -0.47 -6.99 -0.36 1.49e-11 Developmental language disorder (linguistic errors); CRC cis rs17756712 0.725 rs2294667 chr6:617523 A/T cg16786516 chr6:604617 EXOC2 0.46 5.71 0.3 2.47e-8 Vertical cup-disc ratio; CRC cis rs6546550 0.630 rs9309429 chr2:69995580 A/G cg02498382 chr2:70120550 SNRNP27 -0.41 -6.34 -0.33 7.79e-10 Prevalent atrial fibrillation; CRC cis rs7618915 0.501 rs11714030 chr3:52765882 C/T cg10802521 chr3:52805072 NEK4 -0.55 -8.72 -0.43 1.44e-16 Bipolar disorder; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg15688767 chr3:125093330 ZNF148 0.45 6.44 0.33 4.19e-10 Response to antipsychotic treatment; CRC cis rs35146811 0.961 rs11771139 chr7:99736059 C/T cg13334819 chr7:99746414 C7orf59 -0.63 -8.37 -0.42 1.67e-15 Coronary artery disease; CRC cis rs17401966 1.000 rs35766535 chr1:10284659 T/C cg19773385 chr1:10388646 KIF1B -0.56 -7.63 -0.39 2.56e-13 Hepatocellular carcinoma; CRC cis rs10242455 0.717 rs72494455 chr7:99336777 C/G cg18809830 chr7:99032528 PTCD1 -0.8 -5.98 -0.31 5.96e-9 Blood metabolite levels; CRC cis rs1799949 0.965 rs11651623 chr17:41329847 G/A cg25072359 chr17:41440525 NA 0.43 6.36 0.33 6.77e-10 Menopause (age at onset); CRC cis rs798554 0.759 rs798495 chr7:2797267 T/C cg19717773 chr7:2847554 GNA12 -0.47 -6.7 -0.35 9.22e-11 Height; CRC cis rs1881797 1.000 rs10158379 chr1:247686352 C/A cg18198730 chr1:247681584 NA 0.54 8.43 0.42 1.08e-15 Acute lymphoblastic leukemia (childhood); CRC cis rs514406 0.861 rs554760 chr1:53266749 G/A cg08859206 chr1:53392774 SCP2 0.45 6.94 0.36 2.08e-11 Monocyte count; CRC trans rs4332037 0.722 rs55934553 chr7:1914059 T/C cg11693508 chr17:37793320 STARD3 0.51 6.3 0.33 9.7e-10 Bipolar disorder; CRC cis rs6599388 0.803 rs11248057 chr4:906131 C/G cg07828340 chr4:882639 GAK 0.55 7.21 0.37 3.81e-12 Parkinson's disease; CRC trans rs1656966 1.000 rs1656966 chr3:186466252 C/T cg19160555 chr6:143267454 HIVEP2 0.4 6.22 0.32 1.49e-9 Myopia (pathological); CRC cis rs4964805 0.657 rs11111787 chr12:104189499 C/T cg02344784 chr12:104178138 NT5DC3 0.79 14.94 0.64 6.83e-39 Attention deficit hyperactivity disorder; CRC cis rs780096 0.526 rs2911713 chr2:27640980 G/A cg22903471 chr2:27725779 GCKR -0.37 -6.0 -0.31 5.23e-9 Total body bone mineral density; CRC cis rs7917772 0.503 rs7904955 chr10:104367092 C/T cg11453585 chr10:104263688 ACTR1A;SUFU 0.87 15.81 0.66 2.92e-42 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC cis rs7618915 0.547 rs62255362 chr3:52699741 C/G cg07507251 chr3:52567010 NT5DC2 0.42 6.06 0.32 3.7e-9 Bipolar disorder; CRC cis rs6952808 0.609 rs12699449 chr7:1951227 G/C cg02951883 chr7:2050386 MAD1L1 -0.55 -9.05 -0.45 1.32e-17 Bipolar disorder and schizophrenia; CRC cis rs73206853 0.764 rs55859138 chr12:110775610 G/A cg12870014 chr12:110450643 ANKRD13A 0.8 7.71 0.39 1.55e-13 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC cis rs4743820 0.651 rs10733738 chr9:93929352 G/A cg14446406 chr9:93919335 NA -0.76 -13.38 -0.59 6.45e-33 Ulcerative colitis;Inflammatory bowel disease; CRC trans rs11098499 0.954 rs10014845 chr4:120301077 T/G cg25214090 chr10:38739885 LOC399744 0.62 9.74 0.47 7.35e-20 Corneal astigmatism; CRC cis rs9303542 0.527 rs62066689 chr17:46609092 T/C cg04904318 chr17:46607828 HOXB1 -0.54 -6.33 -0.33 7.85e-10 Ovarian cancer;Epithelial ovarian cancer; CRC trans rs801193 0.613 rs2016325 chr7:66323500 T/C cg18876405 chr7:65276391 NA -0.46 -7.44 -0.38 8.86e-13 Aortic root size; CRC cis rs540254 0.578 rs4656271 chr1:160782942 A/G cg20255094 chr1:160771763 LY9 0.49 6.34 0.33 7.78e-10 Blood protein levels; CRC cis rs12620038 0.525 rs7598661 chr2:47468955 C/T cg13204236 chr2:47476732 NA 0.31 5.79 0.3 1.62e-8 Survival in pancreatic cancer; CRC cis rs4713118 0.527 rs4713151 chr6:28136356 G/A cg21251018 chr6:28226885 NKAPL 0.48 6.17 0.32 2.02e-9 Parkinson's disease; CRC cis rs10883723 0.703 rs7898410 chr10:104245858 T/C cg11453585 chr10:104263688 ACTR1A;SUFU 0.91 17.46 0.69 8.83e-49 Allergic disease (asthma, hay fever or eczema); CRC cis rs9928842 0.823 rs11149811 chr16:75300708 C/G cg08657710 chr16:75258780 CTRB1 -0.57 -6.48 -0.34 3.28e-10 Alcoholic chronic pancreatitis; CRC cis rs7552404 0.691 rs5745449 chr1:76344711 A/T cg03433033 chr1:76189801 ACADM -0.68 -8.4 -0.42 1.35e-15 Blood metabolite levels;Acylcarnitine levels; CRC cis rs736408 0.562 rs12497998 chr3:52793602 C/T cg18404041 chr3:52824283 ITIH1 -0.41 -8.46 -0.42 9e-16 Bipolar disorder; CRC cis rs7107174 1.000 rs2450129 chr11:77940385 T/C cg02023728 chr11:77925099 USP35 0.53 8.25 0.41 3.73e-15 Testicular germ cell tumor; CRC cis rs2839186 0.771 rs2839155 chr21:47639992 A/G cg13012494 chr21:47604986 C21orf56 0.45 6.95 0.36 1.94e-11 Testicular germ cell tumor; CRC cis rs853679 0.517 rs4713152 chr6:28137454 G/A cg15845792 chr6:28175446 NA 1.04 13.89 0.61 7.67e-35 Depression; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg17105206 chr16:67211972 KIAA0895L 0.45 7.59 0.39 3.26e-13 Liver disease severity in Alagille syndrome; CRC cis rs1862618 0.641 rs170733 chr5:56249251 A/G cg24531977 chr5:56204891 C5orf35 0.67 10.31 0.49 8.52e-22 Initial pursuit acceleration; CRC cis rs1448094 0.967 rs10863118 chr12:86339232 C/G cg02569458 chr12:86230093 RASSF9 0.38 6.57 0.34 1.99e-10 Major depressive disorder; CRC cis rs1046896 0.503 rs12947062 chr17:80686370 A/G cg16060761 chr17:80687452 NA 0.53 8.12 0.41 9.73e-15 Glycated hemoglobin levels; CRC cis rs2624839 0.704 rs1046956 chr3:50222926 T/A cg05623727 chr3:50126028 RBM5 -0.4 -6.09 -0.32 3.07e-9 Intelligence (multi-trait analysis); CRC cis rs13082711 0.522 rs479302 chr3:27363033 A/G cg02860705 chr3:27208620 NA 0.46 6.78 0.35 5.6e-11 Systolic blood pressure;Diastolic blood pressure;Blood pressure; CRC cis rs868943 0.743 rs11153591 chr6:116328533 A/T cg05304507 chr6:116381966 FRK 0.3 6.71 0.35 8.67e-11 Total cholesterol levels; CRC cis rs34172651 0.917 rs200529 chr16:24758502 T/C cg06028605 chr16:24865363 SLC5A11 -0.4 -7.67 -0.39 1.91e-13 Intelligence (multi-trait analysis); CRC cis rs875971 0.862 rs7809814 chr7:65615397 G/A cg11764359 chr7:65958608 NA -0.61 -9.41 -0.46 9.1e-19 Aortic root size; CRC cis rs2832191 1.000 rs9984793 chr21:30486471 T/C cg08807101 chr21:30365312 RNF160 -0.62 -10.02 -0.48 8.3e-21 Dental caries; CRC cis rs2228479 0.850 rs12597299 chr16:89822364 C/A cg06558623 chr16:89946397 TCF25 1.13 10.45 0.5 2.85e-22 Skin colour saturation; CRC cis rs9905704 0.846 rs302863 chr17:56698827 A/G cg12560992 chr17:57184187 TRIM37 -0.55 -7.84 -0.4 6.25e-14 Testicular germ cell tumor; CRC cis rs9910055 0.762 rs7213436 chr17:42252163 A/G cg16434002 chr17:42200994 HDAC5 0.45 6.03 0.32 4.4e-9 Total body bone mineral density; CRC cis rs1215050 0.791 rs165254 chr4:98763564 C/T cg05340658 chr4:99064831 C4orf37 0.47 6.88 0.35 3.09e-11 Waist-to-hip ratio adjusted for body mass index; CRC cis rs870825 0.929 rs72689260 chr4:185590656 G/T cg04058563 chr4:185651563 MLF1IP 0.56 5.89 0.31 9.54e-9 Blood protein levels; CRC cis rs12995491 0.731 rs56188884 chr2:88508657 G/A cg14558114 chr2:88469736 THNSL2 -0.43 -6.35 -0.33 6.97e-10 Response to metformin (IC50); CRC cis rs6963495 0.818 rs6973974 chr7:105170629 C/T cg13798780 chr7:105162888 PUS7 0.68 8.04 0.41 1.59e-14 Bipolar disorder (body mass index interaction); CRC cis rs79349575 0.715 rs55724082 chr17:47017879 G/A cg00947319 chr17:47005597 UBE2Z -0.34 -5.89 -0.31 9.41e-9 Type 2 diabetes; CRC cis rs992157 0.560 rs6436048 chr2:219109033 C/T cg00012203 chr2:219082015 ARPC2 0.52 8.33 0.42 2.23e-15 Colorectal cancer; CRC cis rs1904096 0.506 rs7697827 chr4:95184748 G/A cg11021082 chr4:95130006 SMARCAD1 -0.5 -7.51 -0.38 5.56e-13 Type 2 diabetes; CRC cis rs9910055 0.529 rs228746 chr17:42173752 T/C cg13607699 chr17:42295918 UBTF -0.48 -6.23 -0.32 1.47e-9 Total body bone mineral density; CRC cis rs11971779 0.648 rs9656512 chr7:139054046 A/G cg07862535 chr7:139043722 LUC7L2 0.57 7.35 0.38 1.61e-12 Diisocyanate-induced asthma; CRC cis rs10883723 0.810 rs7069356 chr10:104254359 G/C cg04362960 chr10:104952993 NT5C2 -0.43 -6.1 -0.32 2.92e-9 Allergic disease (asthma, hay fever or eczema); CRC cis rs7772486 0.686 rs9373473 chr6:146082282 A/G cg23711669 chr6:146136114 FBXO30 0.65 10.7 0.51 3.95e-23 Lobe attachment (rater-scored or self-reported); CRC cis rs12024301 0.557 rs6698036 chr1:183603017 A/G cg11505048 chr1:183622726 RGL1;APOBEC4 0.75 6.81 0.35 4.6e-11 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs1044826 0.642 rs295481 chr3:139228811 C/T cg00490450 chr3:139108681 COPB2 0.43 6.45 0.33 4.1e-10 Obesity-related traits; CRC cis rs10504229 0.683 rs11786523 chr8:58131319 G/C cg02290350 chr8:58132656 NA -0.58 -8.16 -0.41 7.29e-15 Developmental language disorder (linguistic errors); CRC cis rs7771547 0.519 rs2057351 chr6:36361682 G/A cg07856975 chr6:36356162 ETV7 0.48 6.09 0.32 3.15e-9 Platelet distribution width; CRC cis rs9811920 0.609 rs17174947 chr3:99598884 C/T cg07805332 chr3:99536008 MIR548G;C3orf26 -0.51 -7.68 -0.39 1.84e-13 Axial length; CRC cis rs3106136 0.967 rs61004493 chr4:95163317 T/C cg11021082 chr4:95130006 SMARCAD1 -0.46 -7.15 -0.37 5.81e-12 Capecitabine sensitivity; CRC cis rs2976388 1.000 rs2976398 chr8:143764879 G/C cg04969067 chr8:143858791 LYNX1 -0.36 -6.12 -0.32 2.62e-9 Urinary tract infection frequency; CRC trans rs11098499 0.954 rs10006706 chr4:120409152 A/G cg25214090 chr10:38739885 LOC399744 0.63 10.08 0.49 5.36e-21 Corneal astigmatism; CRC cis rs72717009 0.825 rs7529225 chr1:161479352 G/A cg10431340 chr1:161279108 MPZ -0.52 -7.02 -0.36 1.28e-11 Rheumatoid arthritis; CRC cis rs780096 0.526 rs11127013 chr2:27692973 A/G cg24768116 chr2:27665128 KRTCAP3 -0.35 -7.66 -0.39 2.03e-13 Total body bone mineral density; CRC cis rs875971 0.862 rs1981799 chr7:65955559 T/C cg11764359 chr7:65958608 NA 0.63 10.13 0.49 3.71e-21 Aortic root size; CRC cis rs6747952 0.866 rs6726348 chr2:239084119 C/T cg07480446 chr2:239069576 NA -0.37 -6.81 -0.35 4.59e-11 Mean corpuscular hemoglobin concentration; CRC trans rs7647973 0.710 rs12637313 chr3:49645458 A/G cg21659725 chr3:3221576 CRBN -0.66 -7.06 -0.36 1e-11 Menarche (age at onset); CRC cis rs12692738 0.526 rs355830 chr2:165616503 C/G cg03182029 chr2:165697222 COBLL1 0.51 6.09 0.32 3.18e-9 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);Waist-to-hip ratio adjusted for BMI in non-smokers;Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction);Waist-to-hip ratio adjusted for body mass index; CRC cis rs2727020 0.523 rs4115783 chr11:49556026 G/A cg27395922 chr11:50257633 LOC441601 0.36 5.78 0.3 1.71e-8 Coronary artery disease; CRC cis rs12142240 0.698 rs66911505 chr1:46823298 A/G cg14993813 chr1:46806288 NSUN4 -0.49 -6.22 -0.32 1.55e-9 Menopause (age at onset); CRC cis rs7918232 0.941 rs1775350 chr10:27441973 C/T cg14240646 chr10:27532245 ACBD5 0.82 9.2 0.45 4.12e-18 Breast cancer; CRC cis rs77972916 0.609 rs72790903 chr2:43561985 A/G cg06169590 chr2:43455088 ZFP36L2;LOC100129726 -0.64 -5.67 -0.3 3.09e-8 Granulocyte percentage of myeloid white cells; CRC cis rs748404 0.697 rs1814323 chr15:43563237 T/C cg02155558 chr15:43621948 ADAL;LCMT2 -0.45 -6.73 -0.35 7.65e-11 Lung cancer; CRC cis rs6963495 0.818 rs115609508 chr7:105163716 C/A cg02135003 chr7:105160482 PUS7 -0.9 -12.2 -0.56 1.71e-28 Bipolar disorder (body mass index interaction); CRC cis rs12477438 0.765 rs10193039 chr2:99692373 A/T cg14399236 chr2:99771627 LIPT1;TSGA10 -0.62 -8.47 -0.42 8.34e-16 Chronic sinus infection; CRC cis rs11212617 0.837 rs4754298 chr11:108023284 G/A cg14761454 chr11:108092087 ATM;NPAT 0.44 6.64 0.34 1.32e-10 Response to metformin in type 2 diabetes (glycemic); CRC cis rs9372498 0.536 rs62422227 chr6:118957200 C/G cg01339444 chr6:118972232 C6orf204 0.54 5.98 0.31 5.97e-9 Diastolic blood pressure; CRC cis rs7074356 0.569 rs7090863 chr10:82021393 C/A cg27171509 chr10:82033454 MAT1A -0.47 -8.4 -0.42 1.35e-15 Borderline personality disorder; CRC cis rs2032447 0.867 rs9295683 chr6:26069495 C/T cg17691542 chr6:26056736 HIST1H1C 0.39 5.61 0.3 4.27e-8 Intelligence (multi-trait analysis); CRC cis rs250677 0.641 rs2915807 chr5:148450950 A/G cg23229984 chr5:148520753 ABLIM3 0.57 7.51 0.38 5.45e-13 Breast cancer; CRC cis rs9291683 0.588 rs6857693 chr4:10018435 G/A cg00071950 chr4:10020882 SLC2A9 0.68 13.33 0.59 1.07e-32 Bone mineral density; CRC cis rs9381040 0.610 rs2294694 chr6:41046177 G/A cg09580153 chr6:41068724 NFYA;LOC221442 -0.42 -5.94 -0.31 7.32e-9 Alzheimer's disease (late onset); CRC cis rs883565 0.771 rs2056613 chr3:39125293 G/T cg01426195 chr3:39028469 NA -0.54 -8.3 -0.42 2.82e-15 Handedness; CRC cis rs853679 0.517 rs9357063 chr6:28060005 G/A cg12273811 chr6:28175739 NA 0.74 9.39 0.46 1.04e-18 Depression; CRC cis rs561341 1.000 rs2470267 chr17:30274132 G/A cg23018236 chr17:30244563 NA -0.57 -7.41 -0.38 1.09e-12 Hip circumference adjusted for BMI; CRC trans rs877282 0.853 rs10904544 chr10:756966 A/G cg22713356 chr15:30763199 NA 1.19 13.88 0.61 8.08e-35 Uric acid levels; CRC cis rs3106136 0.609 rs28696050 chr4:95136630 G/C cg11021082 chr4:95130006 SMARCAD1 -0.47 -6.81 -0.35 4.72e-11 Capecitabine sensitivity; CRC cis rs9291683 0.530 rs10939620 chr4:9946132 C/T cg00071950 chr4:10020882 SLC2A9 -0.64 -11.74 -0.54 8.09e-27 Bone mineral density; CRC trans rs10021731 0.668 rs7698363 chr4:115413574 A/G cg25927708 chr2:119603813 EN1 -0.33 -6.09 -0.32 3.21e-9 Optic disc area; CRC trans rs58235267 0.543 rs2539990 chr2:63170185 C/T cg05376469 chr2:102649931 NA -0.36 -6.18 -0.32 1.86e-9 Prostate-specific antigen levels (conditioned on lead SNPs); CRC cis rs7726839 0.540 rs74553517 chr5:665671 C/T cg09021430 chr5:549028 NA -0.72 -7.85 -0.4 5.9e-14 Obesity-related traits; CRC cis rs12188164 0.515 rs11744936 chr5:412112 C/T cg21972741 chr5:435613 AHRR 0.45 5.95 0.31 6.89e-9 Cystic fibrosis severity; CRC cis rs76878669 0.561 rs7125752 chr11:66162419 C/T cg18002602 chr11:66138449 SLC29A2 -0.31 -6.69 -0.35 9.46e-11 Educational attainment (years of education); CRC cis rs1215050 0.791 rs2123099 chr4:98803456 A/G cg05340658 chr4:99064831 C4orf37 0.47 6.96 0.36 1.84e-11 Waist-to-hip ratio adjusted for body mass index; CRC cis rs2115630 0.645 rs3825878 chr15:85174755 C/T cg17507749 chr15:85114479 UBE2QP1 -0.4 -6.0 -0.31 5.17e-9 P wave terminal force; CRC trans rs4714291 0.802 rs7759622 chr6:40114735 C/T cg02267698 chr19:7991119 CTXN1 -0.49 -6.67 -0.35 1.06e-10 Strep throat; CRC cis rs801193 1.000 rs7783924 chr7:66209057 A/C cg11764359 chr7:65958608 NA 0.54 8.25 0.41 3.77e-15 Aortic root size; CRC cis rs597539 0.652 rs686390 chr11:68656077 T/C cg06028808 chr11:68637592 NA 0.39 5.91 0.31 8.36e-9 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC trans rs8002861 0.619 rs9562516 chr13:44431738 T/C cg12856521 chr11:46389249 DGKZ 0.47 7.62 0.39 2.74e-13 Leprosy; CRC trans rs7618501 1.000 rs2271960 chr3:49878078 A/G cg21665057 chr3:196295764 WDR53;FBXO45 0.78 13.56 0.6 1.39e-33 Intelligence (multi-trait analysis); CRC cis rs4716602 0.596 rs4997808 chr7:156158734 C/G cg16983916 chr7:156159713 NA -0.39 -6.87 -0.35 3.14e-11 Anti-saccade response; CRC cis rs13108904 0.870 rs12642797 chr4:1245990 G/A cg23123621 chr4:1343375 KIAA1530 0.32 5.7 0.3 2.7e-8 Obesity-related traits; CRC cis rs4795419 1 rs4795419 chr17:38166003 G/A cg17467752 chr17:38218738 THRA 0.75 12.18 0.56 1.93e-28 Monocyte percentage of white cells; CRC cis rs4713118 0.662 rs175954 chr6:28011585 A/G cg15845792 chr6:28175446 NA 0.86 12.44 0.57 2.24e-29 Parkinson's disease; CRC cis rs10751667 0.643 rs10751666 chr11:941933 C/T cg01483505 chr11:975446 AP2A2 0.44 7.24 0.37 3.16e-12 Alzheimer's disease (late onset); CRC cis rs4713118 0.513 rs156738 chr6:28014025 G/C cg12273811 chr6:28175739 NA 0.56 8.05 0.41 1.52e-14 Parkinson's disease; CRC cis rs897984 0.806 rs10782001 chr16:30942625 G/A cg02466173 chr16:30829666 NA 0.66 10.0 0.48 1.02e-20 Dementia with Lewy bodies; CRC cis rs9287719 0.934 rs6721510 chr2:10751046 T/C cg00105475 chr2:10696890 NA 0.45 7.09 0.36 8.03e-12 Prostate cancer; CRC cis rs7618915 0.501 rs62253740 chr3:52684128 A/T cg08222913 chr3:52553049 STAB1 -0.33 -6.11 -0.32 2.76e-9 Bipolar disorder; CRC cis rs11628318 0.853 rs10151896 chr14:103039936 G/C cg02094049 chr14:103021097 NA -0.55 -7.38 -0.38 1.3e-12 Platelet count; CRC cis rs2415984 0.579 rs754962 chr14:46962719 T/C cg14871534 chr14:47121158 RPL10L 0.4 5.96 0.31 6.64e-9 Number of children ever born; CRC cis rs1448094 0.556 rs17279916 chr12:86170647 G/A cg06740227 chr12:86229804 RASSF9 0.38 5.83 0.31 1.31e-8 Major depressive disorder; CRC cis rs6952808 0.792 rs35582663 chr7:1948756 G/A cg20295408 chr7:1910781 MAD1L1 -0.44 -6.06 -0.32 3.72e-9 Bipolar disorder and schizophrenia; CRC cis rs72634258 0.945 rs2294889 chr1:8075934 A/G cg00042356 chr1:8021962 PARK7 0.65 7.37 0.38 1.36e-12 Inflammatory bowel disease; CRC trans rs1997103 0.863 rs6956287 chr7:55415107 T/C cg20935933 chr6:143382018 AIG1 0.52 6.56 0.34 2.04e-10 QRS interval (sulfonylurea treatment interaction); CRC cis rs6860806 0.507 rs273917 chr5:131659618 A/G cg02033258 chr5:131593261 PDLIM4 0.38 6.34 0.33 7.76e-10 Breast cancer; CRC trans rs6703335 0.870 rs10803142 chr1:243598234 A/G cg01947585 chr15:59225861 SLTM 0.43 6.22 0.32 1.53e-9 Schizophrenia;Schizophrenia, schizoaffective disorder or bipolar disorder; CRC cis rs35995292 0.534 rs28460817 chr7:38921917 T/C cg19327137 chr7:38886074 VPS41 0.65 10.8 0.51 1.79e-23 Subjective well-being (multi-trait analysis); CRC cis rs10504229 0.679 rs11781858 chr8:58038406 C/T cg02725872 chr8:58115012 NA -0.51 -6.9 -0.36 2.64e-11 Developmental language disorder (linguistic errors); CRC cis rs12142240 0.738 rs41293275 chr1:46806429 A/T cg14993813 chr1:46806288 NSUN4 -0.5 -6.33 -0.33 7.89e-10 Menopause (age at onset); CRC cis rs1799949 1.000 rs2292595 chr17:41290674 G/C cg19454999 chr17:41278357 BRCA1;NBR2 0.55 8.62 0.43 2.82e-16 Menopause (age at onset); CRC cis rs12200560 0.505 rs211175 chr6:97073320 C/T cg06623918 chr6:96969491 KIAA0776 0.53 7.71 0.39 1.52e-13 Coronary heart disease; CRC cis rs853679 0.517 rs6941992 chr6:28106141 T/C cg02683197 chr6:28174875 NA 0.85 10.52 0.5 1.71e-22 Depression; CRC cis rs4927850 1.000 rs7625570 chr3:195747398 A/G cg01181863 chr3:195395398 SDHAP2 -0.57 -7.91 -0.4 4.04e-14 Pancreatic cancer; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg11550426 chr8:59465609 SDCBP 0.44 6.08 0.32 3.42e-9 Response to antipsychotic treatment; CRC cis rs965469 1.000 rs6037567 chr20:3332160 C/A cg25506879 chr20:3388711 C20orf194 -0.37 -5.6 -0.3 4.41e-8 IFN-related cytopenia; CRC cis rs9359856 0.564 rs72915944 chr6:90447226 C/T cg13799429 chr6:90582589 CASP8AP2 -0.72 -7.86 -0.4 5.61e-14 Bipolar disorder; CRC trans rs2908835 0.521 rs6488412 chr12:11612600 G/A cg03979024 chr10:419189 DIP2C -0.4 -6.28 -0.33 1.08e-9 Information processing speed; CRC cis rs7786808 0.707 rs62479983 chr7:158227613 G/A cg09998033 chr7:158218633 PTPRN2 -0.62 -8.76 -0.43 1.08e-16 Obesity-related traits; CRC cis rs9902453 0.704 rs2628179 chr17:28071796 G/C cg26525008 chr17:28256777 EFCAB5;SSH2 -0.59 -8.92 -0.44 3.27e-17 Coffee consumption (cups per day); CRC cis rs875971 0.522 rs1701760 chr7:65473688 A/G cg11764359 chr7:65958608 NA 0.51 7.71 0.39 1.53e-13 Aortic root size; CRC cis rs4731207 0.698 rs10228376 chr7:124493743 T/C cg23710748 chr7:124431027 NA -0.38 -6.08 -0.32 3.42e-9 Cutaneous malignant melanoma; CRC cis rs7085104 0.572 rs284858 chr10:104573936 T/C cg23093090 chr10:104574429 C10orf26 0.43 7.15 0.37 5.79e-12 Immature fraction of reticulocytes;Schizophrenia; CRC cis rs3767633 0.925 rs2298019 chr1:161736035 A/G cg09175582 chr1:161736000 ATF6 0.68 6.03 0.32 4.36e-9 IgG glycosylation; CRC cis rs116095464 0.558 rs6878087 chr5:223117 C/T cg20965017 chr5:231967 SDHA 0.53 5.88 0.31 1.02e-8 Breast cancer; CRC cis rs2019137 0.967 rs902695 chr2:113955074 G/A cg11763394 chr2:113992921 PAX8;LOC440839;LOC654433 -0.49 -7.07 -0.36 9.28e-12 Lymphocyte counts; CRC cis rs1580019 1.000 rs1580019 chr7:32493169 A/T cg06627557 chr7:32535165 LSM5;AVL9 -0.76 -12.1 -0.56 3.83e-28 Cognitive ability; CRC cis rs11203032 0.831 rs10887929 chr10:90948864 T/C cg16672925 chr10:90967113 CH25H 0.46 5.79 0.3 1.66e-8 Heart failure; CRC cis rs875971 0.660 rs3764903 chr7:66098482 G/A cg25985355 chr7:65971099 NA 0.32 5.69 0.3 2.75e-8 Aortic root size; CRC cis rs2243480 1.000 rs4149468 chr7:65825690 T/C cg12463550 chr7:65579703 CRCP 0.72 6.63 0.34 1.35e-10 Diabetic kidney disease; CRC cis rs909674 0.818 rs5750830 chr22:39840828 C/A cg05872129 chr22:39784769 NA -0.49 -8.45 -0.42 9.34e-16 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; CRC cis rs2976388 0.669 rs2976391 chr8:143762724 C/A cg22687807 chr8:143858763 LYNX1 0.42 7.24 0.37 3.21e-12 Urinary tract infection frequency; CRC cis rs1568889 0.877 rs7933326 chr11:28288416 G/A cg06544937 chr11:28130018 METT5D1;KIF18A 0.8 11.43 0.53 1.03e-25 Bipolar disorder; CRC cis rs798554 0.610 rs2248390 chr7:2855594 T/C cg13628971 chr7:2884303 GNA12 0.43 6.7 0.35 9.28e-11 Height; CRC cis rs2243480 1.000 rs2465120 chr7:65620974 C/G cg18252515 chr7:66147081 NA -1.23 -14.38 -0.62 9.77e-37 Diabetic kidney disease; CRC cis rs6964587 0.773 rs17757926 chr7:91987702 T/C cg17063962 chr7:91808500 NA 0.72 10.67 0.51 5.26e-23 Breast cancer; CRC cis rs2739330 0.627 rs9608219 chr22:24274119 G/C cg23131131 chr22:24373011 LOC391322 -0.62 -9.42 -0.46 8.48e-19 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs2180341 1.000 rs9285460 chr6:127640190 A/G cg27446573 chr6:127587934 RNF146 0.99 14.36 0.62 1.17e-36 Breast cancer; CRC cis rs736408 0.677 rs678 chr3:52820981 A/T cg18404041 chr3:52824283 ITIH1 -0.44 -8.72 -0.43 1.43e-16 Bipolar disorder; CRC cis rs9322193 0.887 rs3777949 chr6:149917157 G/A cg13206674 chr6:150067644 NUP43 0.64 9.35 0.46 1.37e-18 Lung cancer; CRC cis rs2976388 0.609 rs2585140 chr8:143806896 A/G cg05569086 chr8:143859399 LYNX1 0.38 6.59 0.34 1.79e-10 Urinary tract infection frequency; CRC cis rs12477438 0.520 rs11685759 chr2:99766217 T/C cg26064155 chr2:99771622 LIPT1;TSGA10 0.9 16.75 0.68 5.43e-46 Chronic sinus infection; CRC cis rs6586163 1.000 rs1926196 chr10:90753748 C/T cg13456138 chr10:90753195 FAS 0.43 6.68 0.35 1.02e-10 Chronic lymphocytic leukemia; CRC cis rs514406 0.571 rs11206004 chr1:53210958 G/A cg25767906 chr1:53392781 SCP2 0.36 5.82 0.31 1.39e-8 Monocyte count; CRC cis rs2933343 0.729 rs1680780 chr3:128612659 G/C cg11901034 chr3:128598214 ACAD9 -0.55 -7.76 -0.39 1.06e-13 IgG glycosylation; CRC cis rs12760731 0.565 rs16852576 chr1:178192371 C/T cg00404053 chr1:178313656 RASAL2 1.05 10.9 0.52 7.99e-24 Obesity-related traits; CRC cis rs9303401 0.646 rs7213269 chr17:57237796 C/T cg02118635 chr17:56770003 RAD51C;TEX14 0.45 6.87 0.35 3.29e-11 Cognitive test performance; CRC cis rs4555082 0.794 rs2735827 chr14:105710600 T/A cg13114125 chr14:105738426 BRF1 -0.77 -11.42 -0.53 1.11e-25 Mean platelet volume;Platelet distribution width; CRC cis rs853679 0.517 rs9295758 chr6:28120663 C/G cg12172441 chr6:28176163 NA 0.64 7.53 0.38 5.03e-13 Depression; CRC cis rs10504229 0.775 rs10504228 chr8:58162053 T/G cg21724239 chr8:58056113 NA 0.65 8.5 0.42 6.78e-16 Developmental language disorder (linguistic errors); CRC cis rs11098499 0.908 rs28559989 chr4:120386627 C/T cg24375607 chr4:120327624 NA 0.5 7.72 0.39 1.4e-13 Corneal astigmatism; CRC cis rs17270561 0.609 rs9356984 chr6:25725481 C/T cg17691542 chr6:26056736 HIST1H1C -0.65 -7.61 -0.39 2.85e-13 Iron status biomarkers; CRC cis rs7301826 0.610 rs7957899 chr12:131279076 T/C cg11011512 chr12:131303247 STX2 0.39 5.82 0.31 1.41e-8 Plasma plasminogen activator levels; CRC cis rs875971 1.000 rs4718307 chr7:65610988 A/G cg12463550 chr7:65579703 CRCP -0.48 -6.92 -0.36 2.34e-11 Aortic root size; CRC cis rs7618915 0.531 rs77146033 chr3:52701501 G/T cg15147215 chr3:52552868 STAB1 -0.64 -10.56 -0.5 1.24e-22 Bipolar disorder; CRC cis rs7586879 1.000 rs7603153 chr2:25116966 T/C cg22495460 chr2:25135724 ADCY3 -0.73 -11.97 -0.55 1.19e-27 Body mass index; CRC cis rs6662572 0.737 rs7413189 chr1:46254330 G/A cg03123370 chr1:45965343 CCDC163P;MMACHC -0.48 -6.3 -0.33 9.58e-10 Blood protein levels; CRC cis rs873946 0.590 rs12259699 chr10:134549692 A/G cg06453172 chr10:134556979 INPP5A -0.64 -8.7 -0.43 1.62e-16 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg17374227 chr4:140374776 RAB33B 0.51 7.33 0.37 1.82e-12 Response to antipsychotic treatment; CRC cis rs1577917 0.958 rs12196377 chr6:86566775 A/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.54 -6.7 -0.35 8.8e-11 Response to antipsychotic treatment; CRC cis rs7945705 0.818 rs4929916 chr11:8824996 C/T cg00186954 chr11:8933980 ST5;C11orf17 0.35 5.6 0.3 4.44e-8 Hemoglobin concentration; CRC trans rs12478296 0.901 rs9653611 chr2:243006956 C/G cg18288967 chr1:45987694 PRDX1 0.61 7.17 0.37 4.98e-12 Obesity-related traits; CRC cis rs1046896 0.514 rs9894705 chr17:80823758 A/C cg02711726 chr17:80685570 FN3KRP 0.5 6.85 0.35 3.67e-11 Glycated hemoglobin levels; CRC cis rs10504229 0.861 rs116923397 chr8:58185162 T/G cg05313129 chr8:58192883 C8orf71 -0.47 -6.96 -0.36 1.9e-11 Developmental language disorder (linguistic errors); CRC cis rs1552244 0.882 rs13077641 chr3:10022935 G/A cg00166722 chr3:10149974 C3orf24 0.61 7.92 0.4 3.81e-14 Alzheimer's disease; CRC cis rs1129187 0.719 rs3805953 chr6:42936900 C/T cg21280719 chr6:42927975 GNMT -0.48 -10.64 -0.51 6.26e-23 Alzheimer's disease in APOE e4+ carriers; CRC cis rs853679 0.517 rs55747925 chr6:28044337 T/C cg12273811 chr6:28175739 NA 0.69 8.83 0.44 6.17e-17 Depression; CRC cis rs916888 0.610 rs199442 chr17:44820122 G/A cg01570182 chr17:44337453 NA 0.77 9.71 0.47 9.48e-20 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs2657888 0.628 rs2638334 chr12:56882528 A/C cg23002907 chr12:56915593 RBMS2 0.39 6.04 0.32 4.2e-9 Adiponectin levels; CRC trans rs875971 0.545 rs6970498 chr7:65740895 A/G cg02869306 chr7:64672164 INTS4L1 -0.44 -6.45 -0.34 3.89e-10 Aortic root size; CRC cis rs10782582 0.564 rs17647711 chr1:76241710 C/G cg03433033 chr1:76189801 ACADM -0.4 -5.71 -0.3 2.57e-8 Daytime sleep phenotypes; CRC cis rs1448094 0.512 rs12314318 chr12:86249238 T/C cg19622623 chr12:86230825 RASSF9 -0.41 -6.76 -0.35 6.45e-11 Major depressive disorder; CRC cis rs8180040 0.676 rs13098228 chr3:47138253 A/G cg10298567 chr3:47292165 KIF9 -0.4 -6.52 -0.34 2.59e-10 Colorectal cancer; CRC cis rs727563 0.636 rs2413653 chr22:42106996 T/C cg06634786 chr22:41940651 POLR3H 0.65 7.34 0.37 1.74e-12 Crohn's disease;Inflammatory bowel disease; CRC cis rs3820068 0.581 rs16851819 chr1:15918739 C/T cg24675056 chr1:15929824 NA -0.49 -6.63 -0.34 1.35e-10 Systolic blood pressure; CRC cis rs3008870 0.583 rs17497947 chr1:67457199 G/T cg11518657 chr1:67396239 MIER1 -0.57 -6.07 -0.32 3.47e-9 Lymphocyte percentage of white cells; CRC trans rs7618501 0.633 rs13060128 chr3:50025028 A/G cg21659725 chr3:3221576 CRBN 0.54 8.53 0.43 5.26e-16 Intelligence (multi-trait analysis); CRC cis rs6088580 0.634 rs6058052 chr20:33047084 A/G cg24642439 chr20:33292090 TP53INP2 0.38 6.27 0.33 1.16e-9 Glomerular filtration rate (creatinine); CRC cis rs1865760 0.827 rs9461227 chr6:25960815 C/T cg16482183 chr6:26056742 HIST1H1C 0.54 7.99 0.4 2.27e-14 Height; CRC cis rs9916302 0.706 rs9906612 chr17:37547631 A/C cg00129232 chr17:37814104 STARD3 0.57 7.01 0.36 1.35e-11 Glomerular filtration rate (creatinine); CRC cis rs873946 0.648 rs1548281 chr10:134552982 C/T cg26818010 chr10:134567672 INPP5A -0.68 -8.75 -0.43 1.11e-16 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CRC cis rs7618501 0.633 rs2008877 chr3:50162291 T/G cg05623727 chr3:50126028 RBM5 -0.43 -7.03 -0.36 1.17e-11 Intelligence (multi-trait analysis); CRC cis rs1953600 0.870 rs2789695 chr10:81946840 C/T cg04850286 chr10:81895943 PLAC9 0.37 6.71 0.35 8.44e-11 Sarcoidosis; CRC cis rs801193 0.569 rs7782587 chr7:66166472 C/T cg12463550 chr7:65579703 CRCP 0.47 6.29 0.33 1.03e-9 Aortic root size; CRC cis rs9322193 0.962 rs3805749 chr6:150093682 C/T cg00933542 chr6:150070202 PCMT1 0.31 6.01 0.31 4.88e-9 Lung cancer; CRC cis rs9457247 0.905 rs444210 chr6:167390242 A/G cg23791538 chr6:167370224 RNASET2 -0.41 -6.65 -0.34 1.25e-10 Crohn's disease; CRC cis rs9309711 0.560 rs6548164 chr2:3472665 C/T cg10845886 chr2:3471009 TTC15 0.36 5.73 0.3 2.29e-8 Neurofibrillary tangles; CRC cis rs35110281 0.805 rs4818855 chr21:45038951 C/T cg04455712 chr21:45112962 RRP1B 0.39 7.59 0.39 3.36e-13 Mean corpuscular volume; CRC cis rs798554 0.757 rs1182176 chr7:2874601 A/G cg17321639 chr7:2759063 NA -0.48 -6.67 -0.35 1.09e-10 Height; CRC cis rs9467711 0.651 rs17587597 chr6:25986451 G/A cg16898833 chr6:26189333 HIST1H4D 0.76 6.09 0.32 3.14e-9 Autism spectrum disorder or schizophrenia; CRC cis rs6951245 0.832 rs79808627 chr7:1092519 C/G cg18402987 chr7:1209562 NA 0.55 6.44 0.33 4.34e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs59901009 0.815 rs10500721 chr11:10203610 A/G cg23875677 chr11:10229755 SBF2 -0.47 -5.91 -0.31 8.6e-9 Hematocrit;Hemoglobin concentration; CRC trans rs9929218 0.954 rs9646284 chr16:68791306 C/G cg04657470 chr2:198365150 HSPE1;HSPD1 -0.86 -12.32 -0.56 6.22e-29 Colorectal cancer; CRC cis rs9435341 0.965 rs1730859 chr1:107617707 A/G cg09367891 chr1:107599246 PRMT6 0.69 10.31 0.49 8.57e-22 Facial morphology (factor 21, depth of nasal alae); CRC cis rs7726839 0.540 rs61731455 chr5:665295 A/G cg16447950 chr5:562315 NA -0.81 -10.49 -0.5 2.1e-22 Obesity-related traits; CRC cis rs2075671 0.903 rs62482252 chr7:100274063 C/A cg16850897 chr7:100343110 ZAN -0.63 -8.83 -0.44 6.29e-17 Other erythrocyte phenotypes; CRC cis rs2992756 0.663 rs3007718 chr1:18808465 T/A cg14356550 chr1:18808102 KLHDC7A -0.39 -5.78 -0.3 1.76e-8 Breast cancer; CRC cis rs765787 0.530 rs4775837 chr15:45537684 G/T cg24006582 chr15:45444508 DUOX1 -0.57 -8.63 -0.43 2.62e-16 Uric acid levels; CRC cis rs929354 0.772 rs1182448 chr7:157021415 G/A cg16102536 chr7:156981717 UBE3C -0.4 -6.8 -0.35 4.8e-11 Body mass index; CRC cis rs7590720 0.731 rs1864253 chr2:216878008 C/G cg25588852 chr2:216877276 MREG -0.36 -7.01 -0.36 1.36e-11 Alcohol dependence; CRC cis rs7246657 0.943 rs10404602 chr19:37825633 A/T cg23950597 chr19:37808831 NA -0.54 -6.41 -0.33 5.19e-10 Coronary artery calcification; CRC cis rs4713118 0.869 rs9295742 chr6:27702832 G/A cg12273811 chr6:28175739 NA 0.53 7.64 0.39 2.4e-13 Parkinson's disease; CRC cis rs3806843 0.766 rs702397 chr5:140050265 A/G cg19875535 chr5:140030758 IK -0.55 -8.85 -0.44 5.44e-17 Depressive symptoms (multi-trait analysis); CRC cis rs11585357 0.689 rs2977293 chr1:17599444 C/T cg08277548 chr1:17600880 PADI3 -0.68 -10.29 -0.49 1.06e-21 Hair shape; CRC cis rs7680126 0.596 rs28441463 chr4:10289577 T/C cg00071950 chr4:10020882 SLC2A9 -0.44 -6.0 -0.31 5.3300000000000004e-09 Urate levels in lean individuals;Urate levels in overweight individuals;Urate levels in obese individuals; CRC cis rs4862750 0.872 rs9998172 chr4:187898773 T/C cg03452623 chr4:187889614 NA -0.93 -21.91 -0.77 3.09e-66 Lobe attachment (rater-scored or self-reported); CRC cis rs7487075 0.619 rs12824565 chr12:46834693 A/G cg22049899 chr12:47219821 SLC38A4 0.32 5.78 0.3 1.77e-8 Itch intensity from mosquito bite; CRC cis rs4919694 0.611 rs2271750 chr10:105174869 A/G cg04362960 chr10:104952993 NT5C2 -0.63 -6.14 -0.32 2.37e-9 Arsenic metabolism; CRC cis rs12760731 0.720 rs7548163 chr1:178306695 G/A cg00404053 chr1:178313656 RASAL2 0.92 9.63 0.47 1.74e-19 Obesity-related traits; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg15921587 chr2:73144353 EMX1 -0.39 -6.02 -0.31 4.57e-9 Myopia (pathological); CRC cis rs2976388 0.578 rs13263987 chr8:143827387 A/C cg20041105 chr8:143859282 LYNX1 -0.42 -6.64 -0.34 1.28e-10 Urinary tract infection frequency; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg05232067 chr8:26240888 BNIP3L 0.44 6.07 0.32 3.61e-9 Response to antipsychotic treatment; CRC cis rs1448094 0.511 rs4492889 chr12:86146735 C/A cg02569458 chr12:86230093 RASSF9 -0.48 -8.08 -0.41 1.27e-14 Major depressive disorder; CRC cis rs891088 0.677 rs11670892 chr19:7185306 C/G cg09779027 chr19:7224513 INSR -0.59 -6.08 -0.32 3.32e-9 Hip circumference adjusted for BMI;Height; CRC trans rs916888 0.821 rs415430 chr17:44859144 C/T cg07870213 chr5:140052090 DND1 -0.85 -10.09 -0.49 4.88e-21 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs10540 1.000 rs35068485 chr11:466032 A/T cg03934478 chr11:495069 RNH1 0.66 7.41 0.38 1.1e-12 Body mass index; CRC cis rs7772486 0.790 rs6926657 chr6:146255794 G/A cg23711669 chr6:146136114 FBXO30 -0.71 -12.51 -0.57 1.25e-29 Lobe attachment (rater-scored or self-reported); CRC cis rs9303280 0.651 rs59716545 chr17:38031857 T/G cg17344932 chr17:38183730 MED24;SNORD124 0.36 5.76 0.3 1.97e-8 Self-reported allergy; CRC cis rs1775148 1 rs1775148 chr1:205757824 C/T cg11965913 chr1:205819406 PM20D1 0.41 6.24 0.33 1.36e-9 Prostate cancer; CRC cis rs17767392 0.881 rs35625243 chr14:71944937 A/G cg13720639 chr14:72061746 SIPA1L1 -0.44 -5.78 -0.3 1.75e-8 Mitral valve prolapse; CRC cis rs17376456 0.825 rs10061377 chr5:93174513 T/C cg21475434 chr5:93447410 FAM172A 0.69 6.8 0.35 5.09e-11 Diabetic retinopathy; CRC cis rs243505 0.762 rs2007404 chr7:148487395 A/G cg09806900 chr7:148480153 CUL1 0.48 6.91 0.36 2.49e-11 Inflammatory bowel disease;Crohn's disease; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg04197313 chr15:67547198 IQCH;AAGAB 0.42 5.96 0.31 6.53e-9 Anxiety disorder; CRC cis rs17345786 1.000 rs17345528 chr3:101294830 A/C cg11279151 chr3:101281821 RG9MTD1 0.67 8.6 0.43 3.25e-16 Colonoscopy-negative controls vs population controls; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg12405341 chr2:233415195 TIGD1;EIF4E2 0.47 6.79 0.35 5.12e-11 Response to antipsychotic treatment; CRC cis rs612683 0.735 rs10493923 chr1:100930254 A/G cg06223162 chr1:101003688 GPR88 -0.37 -6.84 -0.35 3.98e-11 Breast cancer; CRC cis rs2549003 1.000 rs7734334 chr5:131815004 C/A cg00255919 chr5:131827918 IRF1 0.59 11.92 0.55 1.8e-27 Asthma (sex interaction); CRC cis rs6502050 0.835 rs7219138 chr17:80079896 C/T cg19223190 chr17:80058835 NA -0.39 -6.09 -0.32 3.17e-9 Life satisfaction; CRC cis rs9649213 0.614 rs4729432 chr7:97947055 G/C cg09267113 chr7:98030324 BAIAP2L1 -0.92 -11.99 -0.55 9.72e-28 Prostate cancer (SNP x SNP interaction); CRC cis rs7224737 1.000 rs9912088 chr17:40288278 T/C cg02228675 chr17:40259724 DHX58 -0.49 -6.9 -0.36 2.7e-11 Fibrinogen levels; CRC cis rs501120 0.584 rs11517251 chr10:44724052 A/G cg09554077 chr10:44749378 NA 0.65 7.32 0.37 1.9e-12 Coronary artery disease;Coronary heart disease; CRC cis rs7264396 0.635 rs6058366 chr20:34512172 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.61 -10.13 -0.49 3.5e-21 Total cholesterol levels; CRC cis rs6460942 0.591 rs7800823 chr7:12378697 G/T cg20607287 chr7:12443886 VWDE -0.44 -6.51 -0.34 2.78e-10 Coronary artery disease; CRC cis rs13108904 0.875 rs10024013 chr4:1280792 C/T cg19318889 chr4:1322082 MAEA -0.41 -6.07 -0.32 3.47e-9 Obesity-related traits; CRC cis rs9393777 0.513 rs6936555 chr6:26640886 C/T cg12292205 chr6:26970375 C6orf41 -0.6 -6.75 -0.35 6.71e-11 Intelligence (multi-trait analysis); CRC cis rs3785574 0.927 rs2008018 chr17:61954471 C/T cg06873352 chr17:61820015 STRADA 0.44 7.09 0.36 8.13e-12 Height; CRC cis rs3858526 0.883 rs11039584 chr11:5935251 C/G cg05234568 chr11:5960015 NA -0.53 -7.28 -0.37 2.43e-12 DNA methylation (variation); CRC cis rs4664293 1.000 rs10432413 chr2:160495754 T/A cg08347373 chr2:160653686 CD302 -0.47 -7.51 -0.38 5.49e-13 Monocyte percentage of white cells; CRC cis rs7914558 0.966 rs4532960 chr10:104667406 C/T cg15744005 chr10:104629667 AS3MT -0.34 -7.32 -0.37 1.97e-12 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs10870270 1.000 rs11146324 chr10:133767445 A/C cg17892150 chr10:133769511 PPP2R2D -0.74 -10.95 -0.52 5.2e-24 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; CRC cis rs17711722 0.522 rs62469933 chr7:65265639 G/A cg02869306 chr7:64672164 INTS4L1 -0.47 -8.1 -0.41 1.06e-14 Calcium levels; CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg12876261 chr7:56119223 PSPH;CCT6A 0.37 6.14 0.32 2.34e-9 Obesity-related traits; CRC cis rs9902453 0.765 rs2628191 chr17:28051140 T/G cg26525008 chr17:28256777 EFCAB5;SSH2 -0.71 -11.83 -0.55 3.79e-27 Coffee consumption (cups per day); CRC cis rs8177253 1.000 rs8177261 chr3:133480588 A/C cg16262614 chr3:133464971 TF 0.33 5.91 0.31 8.53e-9 Iron status biomarkers; CRC cis rs6693567 0.545 rs1694386 chr1:150377965 C/G cg04165759 chr1:150448943 RPRD2 0.36 5.86 0.31 1.15e-8 Migraine; CRC cis rs4664308 1.000 rs17831251 chr2:160914156 C/T cg03641300 chr2:160917029 PLA2R1 -0.76 -12.86 -0.58 5.86e-31 Idiopathic membranous nephropathy; CRC trans rs1147246 0.714 rs323850 chr12:125878116 C/G cg23470196 chr14:102695671 RAGE 0.41 5.96 0.31 6.4e-9 Amyotrophic lateral sclerosis (sporadic); CRC cis rs12449964 0.524 rs4925094 chr17:17569012 C/T cg09796270 chr17:17721594 SREBF1 -0.47 -8.0 -0.4 2.18e-14 Coronary artery disease or ischemic stroke; CRC cis rs4604732 0.527 rs7539082 chr1:247627260 T/C cg02104434 chr1:247694406 LOC148824;OR2C3 0.6 8.82 0.44 6.95e-17 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CRC cis rs7493 0.755 rs17886036 chr7:94987727 C/A cg19678392 chr7:94953810 PON1 -0.53 -6.63 -0.34 1.39e-10 Yu-Zhi constitution type in type 2 diabetes; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg16543009 chr15:34331514 AVEN;CHRM5 0.4 6.18 0.32 1.91e-9 Liver disease severity in Alagille syndrome; CRC cis rs908922 0.676 rs12132469 chr1:152491856 G/T cg09873164 chr1:152488093 CRCT1 0.37 6.26 0.33 1.18e-9 Hair morphology; CRC cis rs13118159 0.836 rs2276903 chr4:1343405 A/G cg02018176 chr4:1364513 KIAA1530 0.45 7.41 0.38 1.08e-12 Longevity; CRC cis rs10411161 0.702 rs7250193 chr19:52385520 C/T cg09547119 chr19:52391367 ZNF577 -0.45 -5.63 -0.3 3.91e-8 Breast cancer; CRC cis rs56114371 0.530 rs9357045 chr6:27688927 G/A cg20933634 chr6:27740509 NA 0.56 7.04 0.36 1.12e-11 Breast cancer; CRC cis rs4819052 0.679 rs28623526 chr21:46712324 T/C cg11663144 chr21:46675770 NA -0.7 -12.45 -0.57 2.01e-29 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs12142240 0.698 rs66516678 chr1:46810112 G/T cg14993813 chr1:46806288 NSUN4 -0.49 -6.22 -0.32 1.5e-9 Menopause (age at onset); CRC cis rs9322193 0.886 rs2065663 chr6:150081467 A/G cg07701084 chr6:150067640 NUP43 0.56 7.72 0.39 1.42e-13 Lung cancer; CRC cis rs4721295 0.573 rs3779000 chr7:2181628 G/A cg22963979 chr7:1858916 MAD1L1 -0.41 -5.73 -0.3 2.31e-8 Schizophrenia, schizoaffective disorder or bipolar disorder; CRC cis rs9902453 0.967 rs12450956 chr17:28529025 A/G cg26525008 chr17:28256777 EFCAB5;SSH2 0.59 9.17 0.45 5.24e-18 Coffee consumption (cups per day); CRC cis rs4973397 0.643 rs2034413 chr2:232288149 C/T cg13347044 chr2:232276743 NA 0.39 5.78 0.3 1.77e-8 Anti-saccade response; CRC cis rs995000 0.826 rs12023489 chr1:62923858 G/A cg19896129 chr1:63156450 NA 0.41 6.15 0.32 2.24e-9 Triglyceride levels; CRC cis rs4808199 0.948 rs7250368 chr19:19452763 G/A cg03709012 chr19:19516395 GATAD2A 0.88 10.79 0.51 1.93e-23 Nonalcoholic fatty liver disease; CRC cis rs798554 0.757 rs1182176 chr7:2874601 A/G cg19346786 chr7:2764209 NA -0.38 -6.75 -0.35 6.73e-11 Height; CRC cis rs58688157 0.626 rs7941198 chr11:571681 A/G cg01842473 chr11:617407 IRF7;MUPCDH -0.49 -6.39 -0.33 5.82e-10 Systemic lupus erythematosus; CRC cis rs7737355 0.947 rs3776004 chr5:130879431 G/C cg06307176 chr5:131281290 NA 0.45 6.48 0.34 3.26e-10 Life satisfaction; CRC cis rs7809950 0.817 rs2712230 chr7:107294151 G/A cg23024343 chr7:107201750 COG5 0.65 8.83 0.44 6.18e-17 Coronary artery disease; CRC cis rs796364 1.000 rs11895190 chr2:200838613 A/G cg12253985 chr2:200820533 C2orf60;C2orf47 -0.56 -6.05 -0.32 3.98e-9 Schizophrenia; CRC cis rs9322193 0.923 rs12195866 chr6:150014470 A/G cg05861140 chr6:150128134 PCMT1 -0.42 -6.87 -0.35 3.13e-11 Lung cancer; CRC cis rs4727027 0.866 rs3927307 chr7:148774869 C/T cg23583168 chr7:148888333 NA -0.86 -14.21 -0.62 4.56e-36 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC cis rs5769707 0.967 rs763126 chr22:49988574 G/T cg05373962 chr22:49881684 NA 0.33 6.48 0.34 3.36e-10 Monocyte count;Monocyte percentage of white cells; CRC cis rs7666738 0.830 rs7687315 chr4:98900613 A/G cg17366294 chr4:99064904 C4orf37 0.42 6.98 0.36 1.59e-11 Colonoscopy-negative controls vs population controls; CRC cis rs4285028 0.948 rs12488851 chr3:121687192 C/T cg20356878 chr3:121714668 ILDR1 -0.48 -6.95 -0.36 1.93e-11 Multiple sclerosis; CRC cis rs9372498 0.536 rs62424198 chr6:118827247 A/G cg24463073 chr6:118973353 C6orf204 0.52 6.95 0.36 2e-11 Diastolic blood pressure; CRC cis rs8058578 1.000 rs8058578 chr16:30726248 C/T cg00531865 chr16:30841666 NA -0.44 -5.9 -0.31 8.96e-9 Multiple myeloma; CRC cis rs782590 0.967 rs17278044 chr2:55748217 G/C cg18811423 chr2:55921094 PNPT1 0.84 15.45 0.65 7.41e-41 Metabolic syndrome; CRC cis rs9487051 0.872 rs4601178 chr6:109611246 C/T cg21918786 chr6:109611834 NA -0.45 -8.29 -0.42 2.9e-15 Reticulocyte fraction of red cells; CRC cis rs9903692 0.954 rs11651097 chr17:46147039 T/C cg21215337 chr17:46176117 CBX1 0.42 7.78 0.39 9.36e-14 Pulse pressure; CRC cis rs7619708 1 rs7619708 chr3:195810187 T/C cg12923728 chr3:195709715 SDHAP1 0.63 7.8 0.4 8.29e-14 Red cell distribution width; CRC cis rs10991814 0.920 rs76309414 chr9:94104882 T/C cg14446406 chr9:93919335 NA 0.59 6.61 0.34 1.51e-10 Neutrophil percentage of granulocytes; CRC cis rs826838 0.967 rs1352122 chr12:39130885 G/A cg13010199 chr12:38710504 ALG10B -0.41 -5.84 -0.31 1.27e-8 Heart rate; CRC cis rs1150668 0.796 rs9468372 chr6:28379361 T/A cg06470822 chr6:28175283 NA 0.52 7.64 0.39 2.38e-13 Pubertal anthropometrics; CRC cis rs1005277 0.579 rs1780133 chr10:38499509 T/C cg25517755 chr10:38738941 LOC399744 -0.4 -5.85 -0.31 1.16e-8 Extrinsic epigenetic age acceleration; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg06811360 chr17:8089327 NA 0.47 6.12 0.32 2.71e-9 Thyroid stimulating hormone; CRC cis rs8062405 0.755 rs2077031 chr16:28603168 T/A cg05139728 chr16:28306816 SBK1 -0.36 -5.72 -0.3 2.41e-8 Cognitive ability (multi-trait analysis);Cognitive ability; CRC cis rs7633770 0.805 rs11710264 chr3:46661579 T/C cg11219411 chr3:46661640 NA 0.75 13.6 0.6 1.01e-33 Coronary artery disease; CRC cis rs11212617 0.935 rs227070 chr11:108211412 T/G cg12106634 chr11:108092400 ATM;NPAT 0.39 5.6 0.3 4.48e-8 Response to metformin in type 2 diabetes (glycemic); CRC cis rs12971120 0.891 rs12968731 chr18:72169708 G/T cg25817165 chr18:72167213 CNDP2 -0.65 -9.03 -0.45 1.43e-17 Refractive error; CRC cis rs875971 0.564 rs313804 chr7:65514622 A/G cg11764359 chr7:65958608 NA 0.57 8.95 0.44 2.66e-17 Aortic root size; CRC trans rs10982213 0.830 rs2274163 chr9:117188714 C/T cg26289871 chr20:39969385 LPIN3 -0.38 -6.68 -0.35 1.01e-10 Interleukin-6 levels; CRC cis rs40363 0.645 rs250630 chr16:3524242 C/T cg05754148 chr16:3507555 NAT15 0.48 6.71 0.35 8.71e-11 Tuberculosis; CRC cis rs6543140 0.964 rs4851593 chr2:103089227 C/T cg03938978 chr2:103052716 IL18RAP -0.41 -6.52 -0.34 2.61e-10 Blood protein levels; CRC cis rs9488822 0.676 rs11757115 chr6:116362619 C/T cg18764771 chr6:116381957 FRK 0.26 7.45 0.38 8.12e-13 Cholesterol, total;LDL cholesterol; CRC trans rs2243480 0.666 rs1880311 chr7:65276752 G/C cg10756647 chr7:56101905 PSPH -0.71 -7.13 -0.37 6.57e-12 Diabetic kidney disease; CRC cis rs929596 0.563 rs1105880 chr2:234601965 A/G cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.48 -7.41 -0.38 1.1e-12 Total bilirubin levels in HIV-1 infection; CRC cis rs2976388 0.556 rs4736323 chr8:143830359 C/T cg20041105 chr8:143859282 LYNX1 -0.4 -6.16 -0.32 2.09e-9 Urinary tract infection frequency; CRC cis rs3126085 0.515 rs11204995 chr1:152359168 C/T cg09127314 chr1:152161683 NA -0.44 -5.86 -0.31 1.13e-8 Atopic dermatitis; CRC cis rs897984 0.806 rs10782001 chr16:30942625 G/A cg00531865 chr16:30841666 NA 0.5 7.03 0.36 1.2e-11 Dementia with Lewy bodies; CRC cis rs35000415 0.938 rs13227075 chr7:128643297 T/C cg19972273 chr7:128594194 NA 0.68 6.31 0.33 8.75e-10 Systemic lupus erythematosus; CRC cis rs9682041 0.668 rs6784631 chr3:170100476 T/C cg11886554 chr3:170076028 SKIL 1.06 10.83 0.51 1.42e-23 Glomerular filtration rate in non diabetics (creatinine);Glomerular filtration rate (creatinine); CRC cis rs2949837 0.581 rs2949838 chr7:45993924 T/C cg04727332 chr7:45960243 IGFBP3 0.36 5.8 0.3 1.59e-8 Sitting height ratio; CRC trans rs60843830 1.000 rs9213 chr2:218386 G/A cg11347411 chr7:150020925 ACTR3C;LRRC61 0.58 8.89 0.44 4.26e-17 Spherical equivalent (joint analysis main effects and education interaction); CRC cis rs10504229 0.565 rs7010503 chr8:58147127 G/A cg24829409 chr8:58192753 C8orf71 -0.52 -8.15 -0.41 7.73e-15 Developmental language disorder (linguistic errors); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg05759424 chr2:42721296 KCNG3 0.34 6.25 0.33 1.24e-9 Liver disease severity in Alagille syndrome; CRC cis rs2836974 0.555 rs35909862 chr21:40621158 G/A cg17971929 chr21:40555470 PSMG1 -0.71 -10.84 -0.51 1.31e-23 Cognitive function; CRC cis rs826838 0.967 rs826870 chr12:39120250 G/A cg13010199 chr12:38710504 ALG10B -0.4 -5.83 -0.31 1.35e-8 Heart rate; CRC cis rs5769765 0.862 rs9616385 chr22:50313124 C/T cg08270630 chr22:50330655 NA -0.4 -5.61 -0.3 4.4e-8 Schizophrenia; CRC cis rs6076065 0.612 rs11905630 chr20:23326165 G/C cg11657817 chr20:23433608 CST11 0.48 7.1 0.36 7.96e-12 Facial morphology (factor 15, philtrum width); CRC cis rs4660531 1.000 rs4660531 chr1:41839822 G/T cg00290994 chr1:41848739 NA 0.45 6.36 0.33 6.84e-10 Bipolar disorder; CRC cis rs11657217 0.638 rs4313839 chr17:77698619 C/T cg06901238 chr17:77706717 ENPP7 -0.39 -6.28 -0.33 1.08e-9 Diastolic blood pressure response to hydrochlorothiazide in hypertension; CRC trans rs1005277 0.522 rs9417256 chr10:37976990 A/G cg27523141 chr10:43048294 ZNF37B 0.45 6.41 0.33 4.97e-10 Extrinsic epigenetic age acceleration; CRC cis rs2836974 0.897 rs2836924 chr21:40525639 C/T cg06238570 chr21:40685208 BRWD1 0.71 10.1 0.49 4.5e-21 Cognitive function; CRC cis rs11696845 0.666 rs6073533 chr20:43361082 G/T cg25301532 chr20:43378953 KCNK15 -0.41 -7.1 -0.36 7.86e-12 Obesity-related traits; CRC cis rs2115630 0.905 rs1975277 chr15:85329558 C/T cg09876464 chr15:85330779 ZNF592 0.47 8.14 0.41 8.19e-15 P wave terminal force; CRC cis rs4665809 0.590 rs962217 chr2:26438276 T/C cg04944784 chr2:26401820 FAM59B -0.84 -10.82 -0.51 1.54e-23 Gut microbiome composition (summer); CRC cis rs7937682 0.632 rs7128862 chr11:111755435 C/T cg19812747 chr11:111475976 SIK2 0.42 6.08 0.32 3.39e-9 Primary sclerosing cholangitis; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg05391628 chr12:49463937 RHEBL1 0.52 6.78 0.35 5.72e-11 Thyroid stimulating hormone; CRC cis rs289828 0.868 rs3771888 chr2:152138789 A/G cg06191203 chr2:152266755 RIF1 -0.4 -5.67 -0.3 3.05e-8 Blood protein levels; CRC cis rs1129187 0.967 rs9462857 chr6:42943098 T/C cg10862848 chr6:42927986 GNMT -0.37 -8.7 -0.43 1.66e-16 Alzheimer's disease in APOE e4+ carriers; CRC cis rs35110281 0.627 rs6518268 chr21:44967448 A/G cg04455712 chr21:45112962 RRP1B 0.39 7.31 0.37 2.11e-12 Mean corpuscular volume; CRC cis rs7615952 0.576 rs4646748 chr3:125826329 G/A cg06494592 chr3:125709126 NA -0.55 -6.52 -0.34 2.65e-10 Blood pressure (smoking interaction); CRC cis rs2153535 0.580 rs718503 chr6:8527463 A/T cg21535247 chr6:8435926 SLC35B3 0.48 7.36 0.38 1.49e-12 Motion sickness; CRC cis rs9443645 0.870 rs9350799 chr6:79723651 C/A cg05283184 chr6:79620031 NA -0.56 -8.67 -0.43 2.06e-16 Intelligence (multi-trait analysis); CRC cis rs853679 0.517 rs9393890 chr6:28063855 C/T cg25164649 chr6:28176230 NA 0.75 9.32 0.46 1.72e-18 Depression; CRC cis rs9858542 0.953 rs9824092 chr3:49674147 C/G cg07274523 chr3:49395745 GPX1 0.46 5.93 0.31 7.77e-9 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs4665809 0.816 rs2384359 chr2:26371364 T/C cg22920501 chr2:26401640 FAM59B -0.68 -8.58 -0.43 3.8e-16 Gut microbiome composition (summer); CRC cis rs6952809 1.000 rs12671804 chr7:2449740 C/T cg23289794 chr7:2394357 EIF3B -0.42 -5.6 -0.3 4.45e-8 Multiple sclerosis; CRC cis rs9300255 0.722 rs28592876 chr12:123866429 G/A cg00376283 chr12:123451042 ABCB9 -0.53 -6.55 -0.34 2.15e-10 Neutrophil percentage of white cells; CRC trans rs3733585 0.673 rs4235348 chr4:9951968 T/C cg26043149 chr18:55253948 FECH -0.5 -7.71 -0.39 1.51e-13 Cleft plate (environmental tobacco smoke interaction); CRC cis rs853679 0.598 rs9380054 chr6:28067537 G/A cg15786705 chr6:28176104 NA 0.76 9.6 0.47 2.1e-19 Depression; CRC cis rs35110281 0.714 rs7277539 chr21:45053011 A/G cg04455712 chr21:45112962 RRP1B 0.41 8.05 0.41 1.49e-14 Mean corpuscular volume; CRC cis rs11229555 0.645 rs12800531 chr11:58180099 C/T cg15696309 chr11:58395628 NA -0.81 -10.31 -0.49 8.83e-22 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; CRC cis rs10504229 0.679 rs7839948 chr8:58130607 A/G cg02290350 chr8:58132656 NA -0.58 -8.16 -0.41 7.29e-15 Developmental language disorder (linguistic errors); CRC cis rs898097 0.841 rs8180 chr17:80901036 C/G cg19046167 chr17:80928561 B3GNTL1 0.45 7.12 0.37 6.95e-12 Breast cancer; CRC cis rs2668423 0.502 rs2074898 chr19:1391361 A/G cg02639931 chr19:1387894 NDUFS7 -0.78 -15.65 -0.65 1.19e-41 Nonalcoholic fatty liver disease; CRC cis rs2032447 0.714 rs129129 chr6:25961029 A/G cg12310025 chr6:25882481 NA -0.55 -8.06 -0.41 1.41e-14 Intelligence (multi-trait analysis); CRC cis rs6582630 0.576 rs4882375 chr12:38371939 G/T cg26384229 chr12:38710491 ALG10B -0.53 -7.72 -0.39 1.37e-13 Drug-induced liver injury (flucloxacillin); CRC cis rs2857891 0.817 rs2857885 chr11:6967187 G/A cg04053776 chr11:6947353 ZNF215 0.41 5.86 0.31 1.14e-8 Response to cytadine analogues (cytosine arabinoside); CRC cis rs2898681 0.874 rs59649036 chr4:53741175 T/C cg00338735 chr4:53728038 RASL11B 0.36 5.72 0.3 2.41e-8 Optic nerve measurement (cup area); CRC cis rs2797160 0.875 rs12527010 chr6:125991507 A/G cg05901451 chr6:126070800 HEY2 0.45 7.05 0.36 1.09e-11 Endometrial cancer; CRC cis rs6570726 0.791 rs446362 chr6:145878716 G/T cg05347473 chr6:146136440 FBXO30 0.4 6.07 0.32 3.45e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs7677751 0.806 rs6554163 chr4:55102559 A/T cg17187183 chr4:55093834 PDGFRA 0.5 7.42 0.38 9.77e-13 Corneal astigmatism; CRC cis rs7647973 0.580 rs11130184 chr3:49229930 C/T cg07636037 chr3:49044803 WDR6 0.81 12.56 0.57 7.87e-30 Menarche (age at onset); CRC cis rs60843830 1.000 rs55936726 chr2:258210 T/C cg25945732 chr2:264204 ACP1;SH3YL1 0.71 11.67 0.54 1.46e-26 Spherical equivalent (joint analysis main effects and education interaction); CRC cis rs4862750 0.872 rs56389997 chr4:187894796 A/C cg07414643 chr4:187882934 NA 0.4 6.94 0.36 2.09e-11 Lobe attachment (rater-scored or self-reported); CRC cis rs4563143 0.663 rs10417671 chr19:29235335 T/C cg12667521 chr19:29218732 NA 0.48 7.42 0.38 9.95e-13 Methadone dose in opioid dependence; CRC cis rs10504229 0.596 rs6991216 chr8:58115586 T/C cg02290350 chr8:58132656 NA -0.58 -8.16 -0.41 7.29e-15 Developmental language disorder (linguistic errors); CRC cis rs17270561 0.609 rs2000350 chr6:25763154 T/C cg16482183 chr6:26056742 HIST1H1C 0.71 9.0 0.44 1.79e-17 Iron status biomarkers; CRC cis rs7412746 0.566 rs2864871 chr1:150766964 T/C cg17724175 chr1:150552817 MCL1 0.49 7.23 0.37 3.34e-12 Melanoma; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg02007493 chr14:105647510 NUDT14 0.47 6.19 0.32 1.8e-9 Anxiety disorder; CRC cis rs9522267 0.535 rs7329118 chr13:112232693 C/T cg26182253 chr13:112236782 NA 0.31 6.25 0.33 1.26e-9 Hepatitis; CRC cis rs9814567 0.727 rs4435681 chr3:134344435 C/T cg06109529 chr3:134205091 CEP63;ANAPC13 -0.62 -8.82 -0.44 6.77e-17 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs7824557 0.564 rs2736293 chr8:11234613 T/A cg20542592 chr8:11973495 FAM66D 0.33 5.8 0.3 1.58e-8 Retinal vascular caliber; CRC cis rs847577 0.722 rs6951277 chr7:97711783 A/G cg21770322 chr7:97807741 LMTK2 0.82 18.07 0.71 3.4e-51 Breast cancer; CRC trans rs7647973 0.667 rs4241405 chr3:49642027 C/T cg21659725 chr3:3221576 CRBN -0.66 -7.06 -0.36 1e-11 Menarche (age at onset); CRC cis rs6088580 0.634 rs2378133 chr20:32919505 C/G cg24642439 chr20:33292090 TP53INP2 -0.41 -6.85 -0.35 3.7e-11 Glomerular filtration rate (creatinine); CRC cis rs2455799 0.574 rs2102212 chr3:15704223 C/T cg16303742 chr3:15540471 COLQ -0.39 -6.14 -0.32 2.31e-9 Mean platelet volume; CRC cis rs6963495 0.818 rs73192124 chr7:105171528 C/T cg02135003 chr7:105160482 PUS7 -0.9 -12.08 -0.55 4.87e-28 Bipolar disorder (body mass index interaction); CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg04238871 chr10:126431886 FAM53B 0.49 6.3 0.33 9.75e-10 Thyroid stimulating hormone; CRC cis rs7937682 1.000 rs11608122 chr11:111535105 C/T cg19812747 chr11:111475976 SIK2 0.51 7.96 0.4 2.78e-14 Primary sclerosing cholangitis; CRC trans rs11148252 0.538 rs2408611 chr13:52709742 C/T cg18335740 chr13:41363409 SLC25A15 0.53 7.91 0.4 3.82e-14 Lewy body disease; CRC cis rs7020830 0.867 rs1339553 chr9:37266123 C/G cg14294708 chr9:37120828 ZCCHC7 1.13 23.68 0.79 4.75e-73 Schizophrenia; CRC cis rs1348850 0.567 rs880897 chr2:178532503 C/T cg22681709 chr2:178499509 PDE11A -0.43 -7.92 -0.4 3.58e-14 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs3736485 0.844 rs12438892 chr15:51755240 T/C cg08986416 chr15:51914746 DMXL2 -0.46 -6.48 -0.34 3.38e-10 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs3750082 0.889 rs6462431 chr7:32935439 A/G cg05721444 chr7:32995514 FKBP9 0.49 7.45 0.38 8.12e-13 Glomerular filtration rate (creatinine); CRC cis rs9868809 0.772 rs9811318 chr3:48702606 A/G cg07636037 chr3:49044803 WDR6 -0.65 -6.72 -0.35 7.84e-11 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; CRC cis rs7209700 0.742 rs7217710 chr17:45370582 C/T cg08085267 chr17:45401833 C17orf57 -0.42 -5.93 -0.31 7.68e-9 IgG glycosylation; CRC cis rs1129187 0.967 rs6941212 chr6:42915920 A/G cg03790207 chr6:42947109 PEX6 -0.43 -6.08 -0.32 3.27e-9 Alzheimer's disease in APOE e4+ carriers; CRC cis rs1539053 0.932 rs12038397 chr1:58108237 C/G cg20292791 chr1:58089357 DAB1 -0.34 -5.85 -0.31 1.21e-8 Plasma omega-6 polyunsaturated fatty acid levels (arachidonic acid); CRC cis rs7937682 0.564 rs1944116 chr11:111366792 A/C cg09085632 chr11:111637200 PPP2R1B 0.49 6.5 0.34 2.99e-10 Primary sclerosing cholangitis; CRC cis rs73200209 0.744 rs61937384 chr12:116698606 G/C cg01776926 chr12:116560359 MED13L -0.61 -7.27 -0.37 2.66e-12 Total body bone mineral density; CRC cis rs4713118 0.527 rs4713151 chr6:28136356 G/A cg15845792 chr6:28175446 NA 1.04 13.89 0.61 7.67e-35 Parkinson's disease; CRC cis rs875971 0.505 rs6955582 chr7:65431686 A/G cg18876405 chr7:65276391 NA 0.66 12.04 0.55 6.66e-28 Aortic root size; CRC cis rs9916302 0.706 rs3744349 chr17:37414842 C/T cg07936489 chr17:37558343 FBXL20 -0.83 -10.47 -0.5 2.53e-22 Glomerular filtration rate (creatinine); CRC cis rs1865760 0.663 rs9467656 chr6:25993559 G/A cg16482183 chr6:26056742 HIST1H1C 0.5 7.44 0.38 9.02e-13 Height; CRC cis rs9457247 1.000 rs436707 chr6:167388843 T/C cg23791538 chr6:167370224 RNASET2 -0.38 -5.97 -0.31 6.08e-9 Crohn's disease; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg12977448 chr10:14920832 SUV39H2 0.45 6.11 0.32 2.81e-9 Thyroid stimulating hormone; CRC cis rs875971 0.862 rs6947339 chr7:65888470 T/C cg00343986 chr7:65444356 GUSB 0.45 6.24 0.33 1.37e-9 Aortic root size; CRC cis rs4363385 0.510 rs6677674 chr1:153037601 A/G cg25856811 chr1:152973957 SPRR3 -0.21 -5.66 -0.3 3.38e-8 Inflammatory skin disease; CRC cis rs1691799 0.899 rs1168304 chr12:66738667 A/C cg16791601 chr12:66731901 HELB -0.66 -10.92 -0.52 6.61e-24 White blood cell count (basophil); CRC cis rs12580194 0.593 rs61956272 chr12:55779559 A/T cg23425280 chr12:56401806 NA 0.47 5.66 0.3 3.38e-8 Cancer; CRC cis rs3889199 0.707 rs12402265 chr1:59690602 G/A cg25881383 chr1:59680599 NA -0.37 -5.99 -0.31 5.57e-9 Pulse pressure; CRC trans rs8002861 0.869 rs7989857 chr13:44464090 C/T cg17145862 chr1:211918768 LPGAT1 0.77 15.65 0.65 1.16e-41 Leprosy; CRC cis rs10927875 0.541 rs1739843 chr1:16343254 T/C cg22431228 chr1:16359049 CLCNKA -0.38 -6.91 -0.36 2.52e-11 Dilated cardiomyopathy; CRC cis rs12188164 0.965 rs1056465 chr5:442438 T/A cg21972741 chr5:435613 AHRR 0.54 7.39 0.38 1.21e-12 Cystic fibrosis severity; CRC cis rs7666738 0.830 rs17486413 chr4:99060544 G/T cg05340658 chr4:99064831 C4orf37 0.64 9.93 0.48 1.7e-20 Colonoscopy-negative controls vs population controls; CRC cis rs897984 0.609 rs1108431 chr16:31054607 C/T cg00531865 chr16:30841666 NA -0.42 -5.95 -0.31 6.87e-9 Dementia with Lewy bodies; CRC cis rs875971 0.505 rs1167385 chr7:65513308 G/A cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.51 -7.72 -0.39 1.38e-13 Aortic root size; CRC trans rs11039798 0.588 rs10838970 chr11:48606267 G/T cg03929089 chr4:120376271 NA 0.67 7.17 0.37 5.14e-12 Axial length; CRC cis rs881375 0.715 rs10760119 chr9:123646060 T/C cg09419670 chr9:123605666 PSMD5;LOC253039 0.47 7.24 0.37 3.29e-12 Rheumatoid arthritis; CRC cis rs1153858 1.000 rs4625670 chr15:45652926 C/T cg21132104 chr15:45694354 SPATA5L1 0.6 8.92 0.44 3.33e-17 Homoarginine levels; CRC cis rs1348850 0.874 rs4893822 chr2:178285727 G/T cg02961200 chr2:178257176 LOC100130691;AGPS 0.58 7.95 0.4 3.05e-14 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs2019137 0.967 rs902695 chr2:113955074 G/A cg12889195 chr2:113992843 PAX8;LOC440839;LOC654433 -0.5 -7.22 -0.37 3.55e-12 Lymphocyte counts; CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg02090014 chr7:156802340 MNX1 -0.45 -6.06 -0.32 3.7e-9 Diisocyanate-induced asthma; CRC cis rs10242455 0.702 rs73711294 chr7:99088714 G/A cg18809830 chr7:99032528 PTCD1 -1.32 -9.11 -0.45 8.29e-18 Blood metabolite levels; CRC trans rs8073060 0.586 rs225307 chr17:33918311 A/G cg19694781 chr19:47549865 TMEM160 1.01 13.92 0.61 5.81e-35 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; CRC cis rs6066835 0.867 rs6095276 chr20:47363230 C/T cg18078177 chr20:47281410 PREX1 0.64 5.84 0.31 1.27e-8 Multiple myeloma; CRC cis rs6723226 0.598 rs2710629 chr2:32765844 C/T cg02381751 chr2:32503542 YIPF4 0.47 6.94 0.36 2.09e-11 Intelligence (multi-trait analysis); CRC cis rs853679 0.599 rs149943 chr6:28002388 G/A cg06470822 chr6:28175283 NA 0.76 7.09 0.36 8.3e-12 Depression; CRC cis rs35883536 1.000 rs964906 chr1:101087479 G/A cg14515779 chr1:101123966 NA -0.46 -8.73 -0.43 1.3e-16 Monocyte count; CRC cis rs9300255 0.770 rs7980687 chr12:123822711 G/A cg00376283 chr12:123451042 ABCB9 -0.55 -6.93 -0.36 2.25e-11 Neutrophil percentage of white cells; CRC cis rs9303401 0.659 rs11079358 chr17:56920949 G/T cg10487724 chr17:56770010 TEX14;RAD51C 0.76 9.53 0.47 3.57e-19 Cognitive test performance; CRC cis rs6570726 0.902 rs973855 chr6:145781850 C/T cg05347473 chr6:146136440 FBXO30 -0.37 -5.83 -0.31 1.3e-8 Lobe attachment (rater-scored or self-reported); CRC cis rs7364180 0.515 rs6002503 chr22:42208672 A/G cg03806693 chr22:41940476 POLR3H -0.59 -8.69 -0.43 1.69e-16 Alzheimer's disease biomarkers; CRC cis rs60843830 0.661 rs7588043 chr2:104979 C/T cg00108164 chr2:264199 ACP1;SH3YL1 0.41 5.75 0.3 2.08e-8 Spherical equivalent (joint analysis main effects and education interaction); CRC cis rs7899719 0.744 rs2395293 chr10:77425125 A/C cg24369728 chr10:77472158 NA 0.42 6.62 0.34 1.43e-10 Exploratory eye movement dysfunction in schizophrenia (total eye scanning length); CRC cis rs11690935 1.000 rs312924 chr2:172564021 A/T cg13550731 chr2:172543902 DYNC1I2 1.07 17.79 0.7 4.33e-50 Schizophrenia; CRC cis rs9527 0.830 rs12249194 chr10:104643698 T/C cg15744005 chr10:104629667 AS3MT -0.35 -6.61 -0.34 1.54e-10 Arsenic metabolism; CRC cis rs7726839 0.561 rs4957049 chr5:579080 C/A cg16447950 chr5:562315 NA -0.85 -12.55 -0.57 8.97e-30 Obesity-related traits; CRC cis rs1448094 0.533 rs2169572 chr12:86170370 G/T cg19622623 chr12:86230825 RASSF9 0.37 5.81 0.3 1.49e-8 Major depressive disorder; CRC cis rs10927875 0.541 rs1739840 chr1:16342237 A/G cg24140574 chr1:16342155 HSPB7 0.47 6.67 0.34 1.12e-10 Dilated cardiomyopathy; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg14241323 chr18:13824002 NA 0.36 5.99 0.31 5.53e-9 Liver disease severity in Alagille syndrome; CRC cis rs1992660 0.504 rs10941505 chr5:40399246 G/A cg09067459 chr5:40385259 NA 0.45 7.72 0.39 1.36e-13 Crohn's disease; CRC cis rs2228479 0.702 rs17233253 chr16:89828437 A/G cg19635926 chr16:89946313 TCF25 0.63 5.68 0.3 3.01e-8 Skin colour saturation; CRC cis rs72781680 1.000 rs72788278 chr2:24095285 A/C cg08917208 chr2:24149416 ATAD2B 0.89 9.04 0.45 1.4e-17 Lymphocyte counts; CRC cis rs854765 0.583 rs9912895 chr17:17826020 C/T cg23957660 chr17:17878224 LRRC48 -0.36 -6.73 -0.35 7.6e-11 Total body bone mineral density; CRC cis rs36715 0.951 rs36698 chr5:127549749 T/A cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.61 7.98 0.4 2.52e-14 Breast cancer; CRC cis rs7552404 0.807 rs2066183 chr1:76153745 A/G cg10523679 chr1:76189770 ACADM 0.93 14.19 0.62 5.6e-36 Blood metabolite levels;Acylcarnitine levels; CRC cis rs6502050 0.835 rs7221544 chr17:80087337 C/T cg22110888 chr17:80059540 CCDC57 -0.41 -6.44 -0.33 4.16e-10 Life satisfaction; CRC cis rs9392556 0.734 rs648900 chr6:4109422 T/G cg10424681 chr6:4079350 C6orf201;C6orf146 0.23 5.89 0.31 9.41e-9 Blood metabolite levels; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg01255349 chr12:27676697 PPFIBP1 0.51 6.41 0.33 5.11e-10 Thyroid stimulating hormone; CRC cis rs9660180 0.967 rs12034740 chr1:1728969 C/A cg23982607 chr1:1823379 GNB1 -0.86 -15.66 -0.65 1.12e-41 Body mass index; CRC cis rs10504229 0.728 rs72650855 chr8:58152570 A/G cg21724239 chr8:58056113 NA 0.62 8.38 0.42 1.51e-15 Developmental language disorder (linguistic errors); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg00402069 chr5:89770788 POLR3G;MBLAC2 0.42 6.17 0.32 1.99e-9 Intelligence (multi-trait analysis); CRC cis rs4819052 0.959 rs8130866 chr21:46672112 G/A cg02159808 chr21:46707872 POFUT2;LOC642852 0.62 7.83 0.4 6.87e-14 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs12142240 0.698 rs1475388 chr1:46816465 G/A cg00530320 chr1:46809349 NSUN4 0.57 7.75 0.39 1.19e-13 Menopause (age at onset); CRC cis rs10791097 0.748 rs2282579 chr11:130735482 C/T cg12179176 chr11:130786555 SNX19 0.73 12.26 0.56 9.98e-29 Autism spectrum disorder or schizophrenia;Schizophrenia; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg24971957 chr17:67323276 ABCA5 0.45 6.66 0.34 1.18e-10 Intelligence (multi-trait analysis); CRC cis rs7618915 0.547 rs34537256 chr3:52657472 A/G cg18404041 chr3:52824283 ITIH1 -0.44 -9.05 -0.45 1.26e-17 Bipolar disorder; CRC trans rs11098499 0.954 rs6846442 chr4:120326323 G/A cg25214090 chr10:38739885 LOC399744 0.66 10.47 0.5 2.41e-22 Corneal astigmatism; CRC cis rs7959452 0.535 rs7308481 chr12:69659299 A/G cg14784868 chr12:69753453 YEATS4 0.74 11.89 0.55 2.31e-27 Blood protein levels; CRC cis rs8180040 0.726 rs6785790 chr3:47146932 C/T cg10298567 chr3:47292165 KIF9 -0.35 -5.65 -0.3 3.52e-8 Colorectal cancer; CRC cis rs67311347 1.000 rs7625736 chr3:40441345 C/G cg09455208 chr3:40491958 NA -0.42 -8.58 -0.43 3.73e-16 Renal cell carcinoma; CRC cis rs12541635 0.966 rs16873989 chr8:106966381 C/T cg10147462 chr8:107024639 NA 0.44 7.08 0.36 8.67e-12 Age of smoking initiation; CRC cis rs4970988 0.501 rs11204713 chr1:150694623 T/A cg17724175 chr1:150552817 MCL1 0.58 9.22 0.45 3.63e-18 Urate levels; CRC trans rs1814175 0.781 rs11040681 chr11:49981654 G/T cg03929089 chr4:120376271 NA -0.94 -17.92 -0.7 1.32e-50 Height; CRC cis rs11628318 0.614 rs7149667 chr14:103129441 G/A cg23461800 chr14:103021989 NA 0.68 7.6 0.39 3.07e-13 Platelet count; CRC trans rs7944735 0.507 rs7396592 chr11:48100837 T/C cg03929089 chr4:120376271 NA -0.58 -7.41 -0.38 1.06e-12 Intraocular pressure; CRC cis rs9914988 0.943 rs9913801 chr17:27132105 G/A cg16670446 chr17:27188758 MIR451;MIR144 0.55 8.52 0.43 5.75e-16 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs875971 0.862 rs778684 chr7:65836403 A/T cg12463550 chr7:65579703 CRCP 0.51 7.2 0.37 4.17e-12 Aortic root size; CRC cis rs4713118 0.662 rs9468278 chr6:28028482 C/T cg15845792 chr6:28175446 NA 0.95 13.73 0.6 3.05e-34 Parkinson's disease; CRC cis rs2243480 0.908 rs2460431 chr7:65622846 A/G cg25985355 chr7:65971099 NA 0.53 6.05 0.32 3.9e-9 Diabetic kidney disease; CRC cis rs2243480 1.000 rs12698509 chr7:65418876 C/T cg18252515 chr7:66147081 NA -1.03 -12.2 -0.56 1.68e-28 Diabetic kidney disease; CRC cis rs13108904 0.837 rs4519749 chr4:1280102 A/G cg21620606 chr4:1342894 KIAA1530 0.36 5.91 0.31 8.57e-9 Obesity-related traits; CRC cis rs7680126 0.596 rs10022911 chr4:10140551 A/G cg11266682 chr4:10021025 SLC2A9 -0.4 -5.91 -0.31 8.42e-9 Urate levels in lean individuals;Urate levels in overweight individuals;Urate levels in obese individuals; CRC cis rs425277 0.585 rs364677 chr1:2071765 A/G cg12639453 chr1:2035780 PRKCZ -0.33 -6.21 -0.32 1.59e-9 Height; CRC trans rs1455244 0.700 rs7229302 chr18:11508904 G/T cg18373552 chr10:76871314 SAMD8 0.4 6.34 0.33 7.4e-10 Schizophrenia; CRC cis rs6952808 0.601 rs3778978 chr7:2159817 A/G cg21782813 chr7:2030301 MAD1L1 0.55 9.55 0.47 3.09e-19 Bipolar disorder and schizophrenia; CRC trans rs1005277 0.579 rs2505241 chr10:38442421 T/C cg11292332 chr7:45801988 SEPT13 -0.35 -6.24 -0.33 1.38e-9 Extrinsic epigenetic age acceleration; CRC cis rs9308731 0.644 rs1837368 chr2:111874508 T/C cg04202892 chr2:111875749 ACOXL 0.42 6.71 0.35 8.69e-11 Chronic lymphocytic leukemia; CRC cis rs11711311 0.955 rs12636240 chr3:113391282 A/G cg15478005 chr3:113465772 ATP6V1A;NAA50 0.47 6.41 0.33 5.02e-10 IgG glycosylation; CRC cis rs908922 0.651 rs4845444 chr1:152530125 G/A cg23254163 chr1:152506842 NA 0.49 9.71 0.47 9.49e-20 Hair morphology; CRC cis rs2650000 0.798 rs2701175 chr12:121391671 C/A cg02403541 chr12:121454288 C12orf43 -0.44 -6.42 -0.33 4.68e-10 Metabolic traits;LDL cholesterol; CRC cis rs4689592 0.554 rs3822270 chr4:7069804 C/A cg06697600 chr4:7070879 GRPEL1 -0.5 -7.37 -0.38 1.41e-12 Monocyte percentage of white cells; CRC cis rs12900413 0.603 rs2351494 chr15:90299541 C/T cg24249390 chr15:90295951 MESP1 -0.56 -8.41 -0.42 1.29e-15 Coronary artery aneurysm in Kawasaki disease; CRC cis rs3892630 0.500 rs6510301 chr19:33359791 A/T cg22980127 chr19:33182716 NUDT19 0.66 8.39 0.42 1.41e-15 Red blood cell traits; CRC cis rs10752881 1.000 rs4233192 chr1:182970837 A/C ch.1.3577855R chr1:183094577 LAMC1 -0.85 -15.14 -0.64 1.15e-39 Colorectal cancer; CRC cis rs3858526 1.000 rs11039787 chr11:5965611 C/T cg26762873 chr11:5879799 OR52E8 -0.44 -6.37 -0.33 6.51e-10 DNA methylation (variation); CRC cis rs28386778 0.897 rs11079510 chr17:61820902 T/C cg23090583 chr17:61904693 PSMC5;FTSJ3 1.04 20.37 0.75 3.12e-60 Prudent dietary pattern; CRC cis rs9463078 0.547 rs9472336 chr6:44710392 G/A cg25276700 chr6:44698697 NA 0.31 7.79 0.39 8.87e-14 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; CRC cis rs9435341 0.930 rs61798463 chr1:107565934 G/A cg14671364 chr1:107599128 PRMT6 0.54 7.22 0.37 3.54e-12 Facial morphology (factor 21, depth of nasal alae); CRC cis rs1949733 1.000 rs1357481 chr4:8496221 A/T cg13073564 chr4:8508604 NA -0.46 -7.07 -0.36 9.36e-12 Response to antineoplastic agents; CRC cis rs13191362 0.935 rs34063386 chr6:163041271 T/C cg23758597 chr6:163146217 PARK2 -0.64 -6.36 -0.33 6.71e-10 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs1008375 1.000 rs555 chr4:17625658 A/G cg04450456 chr4:17643702 FAM184B 0.37 6.03 0.32 4.43e-9 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs7647973 0.626 rs1996664 chr3:49878395 A/G cg03060546 chr3:49711283 APEH -0.67 -8.04 -0.41 1.65e-14 Menarche (age at onset); CRC cis rs11105298 0.891 rs11105313 chr12:89923376 A/T cg08166232 chr12:89918718 WDR51B;GALNT4 0.59 7.52 0.38 5.28e-13 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; CRC cis rs651907 0.557 rs3094296 chr3:101400167 A/G cg12386194 chr3:101231763 SENP7 0.47 6.72 0.35 8.25e-11 Colorectal cancer; CRC cis rs9372498 0.536 rs55899435 chr6:118812099 C/T cg07617317 chr6:118971624 C6orf204 0.5 6.23 0.32 1.44e-9 Diastolic blood pressure; CRC cis rs734999 0.545 rs6684865 chr1:2546229 A/G cg18854424 chr1:2615690 NA -0.43 -8.39 -0.42 1.41e-15 Ulcerative colitis; CRC cis rs9649213 0.593 rs7778015 chr7:97920270 T/C cg21770322 chr7:97807741 LMTK2 0.54 9.03 0.45 1.52e-17 Prostate cancer (SNP x SNP interaction); CRC cis rs400736 0.894 rs226242 chr1:8033468 G/A cg25007680 chr1:8021821 PARK7 0.52 7.2 0.37 4.22e-12 Response to antidepressants and depression; CRC cis rs2075371 1.000 rs1421486 chr7:133985196 T/C cg11752832 chr7:134001865 SLC35B4 0.5 7.71 0.39 1.54e-13 Mean platelet volume; CRC cis rs4563143 0.704 rs16961809 chr19:29226299 C/T cg04546413 chr19:29218101 NA 0.43 6.71 0.35 8.46e-11 Methadone dose in opioid dependence; CRC cis rs9462846 0.691 rs67059212 chr6:42913269 T/G cg27588902 chr6:42928151 GNMT -0.34 -5.61 -0.3 4.2e-8 Blood protein levels; CRC cis rs1005277 0.579 rs2983343 chr10:38383332 A/G cg25517755 chr10:38738941 LOC399744 -0.44 -6.42 -0.33 4.85e-10 Extrinsic epigenetic age acceleration; CRC cis rs11758351 1.000 rs1341759 chr6:26195502 G/A cg22723502 chr6:26240528 HIST1H4F -0.38 -5.83 -0.31 1.35e-8 Gout;Renal underexcretion gout; CRC cis rs6543140 0.964 rs4851593 chr2:103089227 C/T cg09003973 chr2:102972529 NA -0.41 -5.93 -0.31 7.7e-9 Blood protein levels; CRC cis rs801193 0.548 rs7805152 chr7:66209253 C/T cg18252515 chr7:66147081 NA -0.41 -5.8 -0.3 1.52e-8 Aortic root size; CRC cis rs3749237 0.595 rs1464567 chr3:49459252 C/G cg07636037 chr3:49044803 WDR6 -0.54 -7.82 -0.4 7.12e-14 Resting heart rate; CRC cis rs1005277 0.579 rs1621040 chr10:38497232 T/C cg17219203 chr10:38645113 HSD17B7P2 -0.41 -5.92 -0.31 8.08e-9 Extrinsic epigenetic age acceleration; CRC cis rs1552244 0.808 rs7615088 chr3:10035896 A/T cg13047869 chr3:10149882 C3orf24 0.51 6.97 0.36 1.74e-11 Alzheimer's disease; CRC cis rs921968 0.584 rs2305833 chr2:219305404 G/C cg02176678 chr2:219576539 TTLL4 0.49 7.96 0.4 2.8e-14 Mean corpuscular hemoglobin concentration; CRC cis rs4862750 0.837 rs1863404 chr4:187874654 T/C cg07414643 chr4:187882934 NA 0.36 6.4 0.33 5.41e-10 Lobe attachment (rater-scored or self-reported); CRC cis rs1728785 0.688 rs698718 chr16:68560185 A/G cg02972257 chr16:68554789 NA -0.58 -7.08 -0.36 9.03e-12 Ulcerative colitis; CRC cis rs801193 1.000 rs10274773 chr7:66133578 G/A cg18876405 chr7:65276391 NA -0.61 -10.74 -0.51 2.87e-23 Aortic root size; CRC cis rs72615157 0.634 rs74774557 chr7:99810425 A/G cg00814883 chr7:100076585 TSC22D4 -0.55 -6.58 -0.34 1.84e-10 Lung function (FEV1/FVC); CRC cis rs10504229 0.953 rs66509078 chr8:58174734 G/C cg02290350 chr8:58132656 NA -0.42 -5.96 -0.31 6.62e-9 Developmental language disorder (linguistic errors); CRC trans rs7819412 0.775 rs11773990 chr8:10935082 T/C cg16141378 chr3:129829833 LOC729375 0.46 6.55 0.34 2.21e-10 Triglycerides; CRC cis rs6691722 0.503 rs7546875 chr1:24703667 T/C cg02336364 chr1:24764700 NIPAL3 0.37 6.19 0.32 1.74e-9 Response to interferon beta in multiple sclerosis; CRC cis rs7640424 0.750 rs13074183 chr3:107851467 G/A cg09227934 chr3:107805635 CD47 -0.43 -6.53 -0.34 2.46e-10 Body mass index; CRC cis rs644799 1.000 rs3177463 chr11:95502128 G/C cg03916912 chr11:95522834 CEP57;FAM76B 0.95 17.43 0.69 1.13e-48 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs6502050 0.835 rs56232956 chr17:80078929 C/T cg22110888 chr17:80059540 CCDC57 -0.41 -6.38 -0.33 6.13e-10 Life satisfaction; CRC cis rs4237845 0.788 rs1962047 chr12:58292707 G/A cg02175503 chr12:58329896 NA 0.53 6.9 0.36 2.68e-11 Intelligence (multi-trait analysis); CRC cis rs812925 0.559 rs2600667 chr2:61404931 A/T cg10580144 chr2:61372316 C2orf74 0.36 7.38 0.38 1.28e-12 Immature fraction of reticulocytes; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg19793034 chr4:1284190 MAEA 0.45 6.39 0.33 5.82e-10 Response to antipsychotic treatment; CRC cis rs1223397 0.651 rs202023 chr6:13304658 C/T cg07912922 chr6:13274314 PHACTR1 0.39 6.04 0.32 4.28e-9 Blood pressure; CRC cis rs67340775 0.541 rs200968 chr6:27859568 T/C cg15845792 chr6:28175446 NA 0.85 8.81 0.44 7.07e-17 Lung cancer in ever smokers; CRC cis rs6582630 0.555 rs8189479 chr12:38308240 C/T cg13010199 chr12:38710504 ALG10B -0.4 -5.74 -0.3 2.16e-8 Drug-induced liver injury (flucloxacillin); CRC cis rs3820068 0.581 rs3940061 chr1:15941276 C/T cg27534772 chr1:16042836 PLEKHM2 0.54 10.43 0.5 3.49e-22 Systolic blood pressure; CRC cis rs2836950 0.520 rs1980407 chr21:40543961 T/C cg06238570 chr21:40685208 BRWD1 -0.63 -9.29 -0.46 2.2e-18 Menarche (age at onset); CRC cis rs270601 0.770 rs10463891 chr5:131597392 C/T cg01305625 chr5:131593812 PDLIM4 -0.34 -6.0 -0.31 5.15e-9 Acylcarnitine levels; CRC cis rs9928842 0.882 rs4737 chr16:75238103 A/G cg09066997 chr16:75300724 BCAR1 -0.54 -6.02 -0.32 4.61e-9 Alcoholic chronic pancreatitis; CRC cis rs8005677 0.828 rs2295680 chr14:23374435 A/G cg25600027 chr14:23388339 RBM23 0.47 7.05 0.36 1.06e-11 Cognitive ability (multi-trait analysis); CRC cis rs1799949 1.000 rs8176120 chr17:41261233 C/T cg05368731 chr17:41323189 NBR1 0.69 10.51 0.5 1.81e-22 Menopause (age at onset); CRC cis rs17376456 0.825 rs10078941 chr5:93279029 C/T cg09848695 chr5:92956644 FAM172A;MIR2277 0.68 6.03 0.32 4.45e-9 Diabetic retinopathy; CRC cis rs9463078 0.617 rs1359336 chr6:45071874 T/A cg25276700 chr6:44698697 NA -0.25 -5.92 -0.31 8.26e-9 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; CRC cis rs2075371 0.897 rs10488428 chr7:133997560 C/T cg20476274 chr7:133979776 SLC35B4 0.72 11.66 0.54 1.6e-26 Mean platelet volume; CRC cis rs2354432 0.882 rs11576360 chr1:146740576 G/A cg25205988 chr1:146714368 CHD1L 1.21 16.46 0.67 7.76e-45 Mitochondrial DNA levels; CRC cis rs9916302 0.660 rs4795367 chr17:37608843 G/C cg15445000 chr17:37608096 MED1 0.36 6.28 0.33 1.08e-9 Glomerular filtration rate (creatinine); CRC cis rs9309473 0.583 rs6705203 chr2:73574600 T/C cg20560298 chr2:73613845 ALMS1 -0.48 -6.48 -0.34 3.33e-10 Metabolite levels; CRC cis rs13256369 0.760 rs7816171 chr8:8575835 T/C cg06671706 chr8:8559999 CLDN23 0.54 7.98 0.4 2.44e-14 Obesity-related traits; CRC cis rs6502050 0.835 rs7212441 chr17:80080047 T/G cg25804541 chr17:80189381 SLC16A3 0.31 6.01 0.31 4.93e-9 Life satisfaction; CRC cis rs936229 0.749 rs7497201 chr15:75190690 A/G cg14664628 chr15:75095509 CSK -0.85 -14.46 -0.62 4.99e-37 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); CRC cis rs2153535 0.580 rs9393021 chr6:8466123 A/G cg07606381 chr6:8435919 SLC35B3 0.68 10.9 0.51 8.26e-24 Motion sickness; CRC cis rs2084637 1.000 rs67890224 chr11:122400289 C/A cg21585512 chr11:122030076 LOC399959 -0.4 -7.29 -0.37 2.39e-12 Stroke; CRC cis rs8060686 0.641 rs112099181 chr16:68154230 T/C cg26727032 chr16:67993705 SLC12A4 -0.6 -8.11 -0.41 1.04e-14 HDL cholesterol;Metabolic syndrome; CRC cis rs317689 0.684 rs315125 chr12:69758884 C/T cg14784868 chr12:69753453 YEATS4 0.58 7.1 0.36 7.7e-12 Response to diuretic therapy; CRC trans rs7615952 0.741 rs13314845 chr3:125644782 C/T cg00769240 chr8:12517080 NA -0.57 -7.05 -0.36 1.04e-11 Blood pressure (smoking interaction); CRC cis rs7786808 0.741 rs7789415 chr7:158227617 C/T cg09998033 chr7:158218633 PTPRN2 -0.63 -8.94 -0.44 2.81e-17 Obesity-related traits; CRC cis rs2652834 0.950 rs2652815 chr15:63401345 T/C cg05507819 chr15:63340323 TPM1 0.45 5.76 0.3 1.89e-8 HDL cholesterol; CRC trans rs7395662 0.517 rs10454483 chr11:48754997 A/G cg21153622 chr11:89784906 NA -0.53 -8.9 -0.44 3.8e-17 HDL cholesterol; CRC cis rs6921919 0.583 rs16894060 chr6:28362471 T/C cg21251018 chr6:28226885 NKAPL 0.38 5.63 0.3 3.95e-8 Autism spectrum disorder or schizophrenia; CRC trans rs3942852 0.774 rs10838813 chr11:48186969 C/A cg15704280 chr7:45808275 SEPT13 -0.75 -9.3 -0.46 2.07e-18 Acute lymphoblastic leukemia (childhood); CRC cis rs7474896 0.583 rs10827818 chr10:38000856 T/C cg25427524 chr10:38739819 LOC399744 -0.59 -7.45 -0.38 8.39e-13 Obesity (extreme); CRC cis rs2579500 0.660 rs6711452 chr2:97139307 G/A cg23100626 chr2:96804247 ASTL 0.25 6.13 0.32 2.55e-9 Eosinophil counts;Eosinophil percentage of white cells; CRC cis rs9435341 0.929 rs1762509 chr1:107592959 A/G cg15468180 chr1:107600409 PRMT6 -0.44 -6.5 -0.34 2.96e-10 Facial morphology (factor 21, depth of nasal alae); CRC cis rs12541335 0.639 rs7834182 chr8:22163112 G/A cg02788857 chr8:22132959 PIWIL2 0.5 8.73 0.43 1.33e-16 Hypertriglyceridemia; CRC cis rs7584330 0.554 rs111512641 chr2:238429538 G/A cg14458575 chr2:238380390 NA 0.57 7.34 0.38 1.67e-12 Prostate cancer; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg20690303 chr4:17513834 QDPR 0.41 6.21 0.32 1.58e-9 Intelligence (multi-trait analysis); CRC trans rs4144743 0.759 rs16941731 chr17:45317022 C/T cg03564338 chr16:50585384 NKD1 -0.54 -6.06 -0.32 3.75e-9 Body mass index; CRC trans rs17685 0.753 rs4732542 chr7:75663203 A/G cg19862616 chr7:65841803 NCRNA00174 0.96 17.67 0.7 1.34e-49 Coffee consumption;Coffee consumption (cups per day); CRC cis rs9807989 0.507 rs4851572 chr2:103019031 G/A cg03938978 chr2:103052716 IL18RAP 0.59 10.17 0.49 2.54e-21 Asthma; CRC cis rs2811415 0.597 rs56143290 chr3:127737383 A/G cg13719885 chr3:127795394 NA -0.37 -5.74 -0.3 2.17e-8 Lung function (FEV1/FVC); CRC cis rs898097 0.691 rs7222773 chr17:80907283 A/G cg03160526 chr17:80928410 B3GNTL1 0.52 8.74 0.43 1.2e-16 Breast cancer; CRC cis rs17376456 0.825 rs12716454 chr5:93272279 A/C cg21475434 chr5:93447410 FAM172A 0.83 7.88 0.4 4.83e-14 Diabetic retinopathy; CRC trans rs7618501 0.602 rs2240326 chr3:50128386 G/A cg21659725 chr3:3221576 CRBN -0.62 -9.76 -0.47 6.07e-20 Intelligence (multi-trait analysis); CRC cis rs1580019 0.563 rs2392071 chr7:32572536 G/A cg06627557 chr7:32535165 LSM5;AVL9 0.95 17.6 0.7 2.43e-49 Cognitive ability; CRC cis rs11864453 0.647 rs3852781 chr16:72123556 T/A cg23815491 chr16:72088622 HP 0.51 7.65 0.39 2.3e-13 Fibrinogen levels; CRC cis rs2228479 0.850 rs11640209 chr16:89807828 C/A cg06558623 chr16:89946397 TCF25 1.14 10.79 0.51 1.99e-23 Skin colour saturation; CRC trans rs2832077 0.527 rs2250141 chr21:30241984 A/T cg14791747 chr16:20752902 THUMPD1 -0.64 -9.97 -0.48 1.26e-20 Cognitive test performance; CRC cis rs8078723 0.966 rs57968500 chr17:38145828 A/G cg17344932 chr17:38183730 MED24;SNORD124 -0.44 -6.9 -0.36 2.62e-11 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); CRC cis rs1799949 0.965 rs799910 chr17:41279561 G/C cg05368731 chr17:41323189 NBR1 0.58 8.7 0.43 1.66e-16 Menopause (age at onset); CRC cis rs977987 0.864 rs37594 chr16:75496943 T/C cg03315344 chr16:75512273 CHST6 -0.58 -9.62 -0.47 1.8e-19 Dupuytren's disease; CRC trans rs3780486 0.846 rs913214 chr9:33135085 G/A cg20290983 chr6:43655470 MRPS18A 1.16 25.19 0.81 8.85e-79 IgG glycosylation; CRC cis rs11098499 0.866 rs12374244 chr4:120281972 A/T cg24375607 chr4:120327624 NA 0.48 7.48 0.38 6.72e-13 Corneal astigmatism; CRC cis rs7927771 0.800 rs35996350 chr11:47389223 A/G cg20307385 chr11:47447363 PSMC3 -0.63 -9.38 -0.46 1.15e-18 Subjective well-being; CRC cis rs1957429 0.808 rs763346 chr14:65330386 A/G cg23373153 chr14:65346875 NA -0.64 -6.61 -0.34 1.54e-10 Pediatric areal bone mineral density (radius); CRC cis rs9928842 0.765 rs6564221 chr16:75224971 C/T cg09066997 chr16:75300724 BCAR1 0.64 6.21 0.32 1.58e-9 Alcoholic chronic pancreatitis; CRC cis rs1448094 0.549 rs4919770 chr12:86238050 G/T cg18827107 chr12:86230957 RASSF9 -0.47 -7.87 -0.4 5.15e-14 Major depressive disorder; CRC cis rs1577917 0.958 rs12213343 chr6:86443019 C/A cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.54 -7.34 -0.37 1.73e-12 Response to antipsychotic treatment; CRC cis rs2073300 0.609 rs8183135 chr20:23384284 C/T cg12062639 chr20:23401060 NAPB 0.8 7.17 0.37 4.9e-12 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs4713118 0.523 rs2179096 chr6:27665920 C/T cg03623178 chr6:28175578 NA 0.56 8.03 0.4 1.75e-14 Parkinson's disease; CRC cis rs7119 0.689 rs8040318 chr15:77803660 A/C cg27398640 chr15:77910606 LINGO1 -0.46 -8.2 -0.41 5.57e-15 Type 2 diabetes; CRC cis rs875971 0.545 rs316323 chr7:65610989 C/T cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.6 -7.82 -0.4 7.12e-14 Aortic root size; CRC cis rs10484885 0.824 rs28372875 chr6:90529343 C/T cg13799429 chr6:90582589 CASP8AP2 -0.72 -7.73 -0.39 1.3e-13 QRS interval (sulfonylurea treatment interaction); CRC trans rs35110281 0.591 rs162390 chr21:44936826 C/T cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.48 7.87 0.4 5.06e-14 Mean corpuscular volume; CRC cis rs4523957 0.928 rs170044 chr17:2197502 C/G cg16513277 chr17:2031491 SMG6 -0.54 -9.17 -0.45 5.11e-18 Autism spectrum disorder or schizophrenia;Schizophrenia; CRC cis rs12476592 0.602 rs262476 chr2:63870607 A/G cg10828910 chr2:63850056 LOC388955 -0.51 -6.3 -0.33 9.67e-10 Childhood ear infection; CRC cis rs6952808 0.689 rs58227534 chr7:2046328 A/G cg02951883 chr7:2050386 MAD1L1 -0.79 -12.96 -0.58 2.47e-31 Bipolar disorder and schizophrenia; CRC cis rs9916302 0.904 rs9898170 chr17:37510092 T/C cg15445000 chr17:37608096 MED1 -0.42 -9.05 -0.45 1.25e-17 Glomerular filtration rate (creatinine); CRC cis rs7762018 1.000 rs7762018 chr6:170113244 G/T cg24289452 chr6:170231220 NA -0.58 -6.93 -0.36 2.23e-11 Thiazide-induced adverse metabolic effects in hypertensive patients; CRC trans rs10504229 0.906 rs7003285 chr8:58173108 A/G cg04077850 chr5:125800366 GRAMD3 0.37 6.27 0.33 1.15e-9 Developmental language disorder (linguistic errors); CRC cis rs6540559 0.546 rs59435160 chr1:210030730 C/A cg21951975 chr1:209979733 IRF6 0.45 6.0 0.31 5.12e-9 Cleft lip with or without cleft palate; CRC cis rs17253792 0.822 rs8007065 chr14:56081272 A/G cg01858014 chr14:56050164 KTN1 -0.87 -7.23 -0.37 3.34e-12 Putamen volume; CRC cis rs7666738 0.830 rs28687737 chr4:99009226 G/A cg17366294 chr4:99064904 C4orf37 0.44 7.39 0.38 1.19e-12 Colonoscopy-negative controls vs population controls; CRC cis rs12431939 0.626 rs7161242 chr14:51716188 A/C cg23942311 chr14:51606299 NA 0.47 6.26 0.33 1.19e-9 Cancer; CRC cis rs6570726 0.764 rs9386125 chr6:145911677 C/T cg05347473 chr6:146136440 FBXO30 0.38 5.71 0.3 2.52e-8 Lobe attachment (rater-scored or self-reported); CRC cis rs8177253 0.665 rs10935074 chr3:133441692 T/G cg01448562 chr3:133502909 NA -0.35 -5.79 -0.3 1.67e-8 Iron status biomarkers; CRC cis rs380904 0.926 rs7842979 chr8:144601896 T/G cg20583945 chr8:144636462 GSDMD 0.5 6.88 0.35 3.12e-11 Venous thromboembolism (SNP x SNP interaction); CRC trans rs916888 0.773 rs199534 chr17:44824213 T/G cg13957321 chr17:43675089 NA 0.52 6.21 0.32 1.62e-9 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs9768139 0.708 rs11771764 chr7:158119871 A/G cg23298862 chr7:158159286 PTPRN2 0.37 5.77 0.3 1.8e-8 Calcium levels; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg04498971 chr17:56084468 SFRS1 0.43 5.98 0.31 5.89e-9 Response to antipsychotic treatment; CRC cis rs2204008 0.626 rs11520260 chr12:38330092 C/T cg26384229 chr12:38710491 ALG10B 0.68 9.52 0.46 3.79e-19 Bladder cancer; CRC cis rs698833 0.926 rs786620 chr2:44595803 C/T cg04920474 chr2:44395004 PPM1B 0.42 6.24 0.33 1.37e-9 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; CRC cis rs10504229 0.683 rs72650839 chr8:58130029 C/T cg24829409 chr8:58192753 C8orf71 -0.55 -8.03 -0.4 1.71e-14 Developmental language disorder (linguistic errors); CRC cis rs7671266 0.589 rs10938772 chr4:10375328 A/G cg11266682 chr4:10021025 SLC2A9 -0.39 -6.14 -0.32 2.34e-9 Cardiovascular disease risk factors; CRC cis rs25422 0.938 rs114309775 chr6:118838782 G/A cg24463073 chr6:118973353 C6orf204 0.52 6.99 0.36 1.51e-11 Renal cell carcinoma; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg17239761 chr22:21213665 SNAP29;PI4KA 0.41 6.27 0.33 1.16e-9 Intelligence (multi-trait analysis); CRC cis rs3096299 0.658 rs12443705 chr16:89547054 C/G cg00750074 chr16:89608354 SPG7 -0.5 -7.6 -0.39 3.1e-13 Multiple myeloma (IgH translocation); CRC cis rs28655083 1.000 rs8059347 chr16:77068259 C/T cg01753188 chr16:77233325 SYCE1L;MON1B -0.57 -8.14 -0.41 8.35e-15 Lobe attachment (rater-scored or self-reported); CRC cis rs9457247 0.508 rs2285147 chr6:167505548 G/A cg07513332 chr6:167530253 CCR6 0.4 7.21 0.37 3.86e-12 Crohn's disease; CRC cis rs6879260 0.963 rs1035412 chr5:179729328 C/T cg23221052 chr5:179740743 GFPT2 -0.65 -10.2 -0.49 2.14e-21 Height; CRC cis rs9296092 0.538 rs9469487 chr6:33516943 G/T cg13560919 chr6:33536144 NA -0.42 -5.86 -0.31 1.14e-8 Age at smoking initiation in chronic obstructive pulmonary disease; CRC cis rs5753037 0.585 rs7954 chr22:30184950 A/G cg01021169 chr22:30184971 ASCC2 -0.42 -6.74 -0.35 7.25e-11 Type 1 diabetes; CRC cis rs12701220 0.503 rs13222294 chr7:1172969 G/A cg04498913 chr7:1135747 C7orf50 -0.51 -5.98 -0.31 5.81e-9 Bronchopulmonary dysplasia; CRC cis rs2760061 0.819 rs708114 chr1:228197496 G/A cg01200585 chr1:228362443 C1orf69 0.39 5.73 0.3 2.22e-8 Diastolic blood pressure; CRC cis rs9311676 0.656 rs55783924 chr3:58403610 C/T cg06643156 chr3:58380774 PXK 0.42 6.38 0.33 5.84e-10 Systemic lupus erythematosus; CRC cis rs478304 0.934 rs517115 chr11:65526988 C/T cg08755490 chr11:65554678 OVOL1 0.44 6.34 0.33 7.57e-10 Acne (severe); CRC trans rs8078472 0.614 rs12950148 chr17:12872802 A/G cg02659581 chr1:3467842 MEGF6 0.39 6.11 0.32 2.77e-9 Joint mobility (Beighton score); CRC cis rs765787 0.530 rs2433229 chr15:45515235 C/A cg24006582 chr15:45444508 DUOX1 -0.57 -8.67 -0.43 2e-16 Uric acid levels; CRC cis rs7546094 1.000 rs11102497 chr1:113109274 T/C cg22162597 chr1:113214053 CAPZA1 0.43 5.94 0.31 7.2e-9 Platelet distribution width; CRC cis rs933688 0.877 rs10474352 chr5:90732225 C/T cg26981201 chr5:90679533 LOC100129716;ARRDC3 1.01 15.56 0.65 2.69e-41 Smoking behavior; CRC trans rs3819340 0.558 rs73162911 chr3:148629012 C/A cg03707696 chr10:81075467 ZMIZ1 0.71 5.96 0.31 6.39e-9 LDL peak particle diameter (total fat intake interaction); CRC cis rs7647973 0.807 rs4955416 chr3:49108428 T/C cg20833759 chr3:49053208 WDR6;DALRD3 0.69 11.33 0.53 2.39e-25 Menarche (age at onset); CRC cis rs7909074 0.831 rs7903412 chr10:45382361 C/T cg05187965 chr10:45406764 TMEM72 -0.37 -8.49 -0.42 7.29e-16 Mean corpuscular volume; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg00441754 chr19:45394894 TOMM40 0.45 6.83 0.35 3.99e-11 Liver disease severity in Alagille syndrome; CRC cis rs6893300 0.524 rs6601073 chr5:179177271 A/G cg14593053 chr5:179126677 CANX -0.51 -8.21 -0.41 5.11e-15 Resting heart rate; CRC cis rs6860806 0.507 rs273912 chr5:131661349 A/C cg04518342 chr5:131593106 PDLIM4 -0.43 -7.03 -0.36 1.19e-11 Breast cancer; CRC cis rs11155671 0.530 rs4870080 chr6:150202644 T/C cg13206674 chr6:150067644 NUP43 0.46 6.49 0.34 3.16e-10 Testicular germ cell tumor; CRC cis rs6545883 0.507 rs6545855 chr2:61532860 G/C cg10580144 chr2:61372316 C2orf74 -0.35 -7.65 -0.39 2.23e-13 Tuberculosis; CRC cis rs12681287 0.511 rs4129535 chr8:87524094 G/T cg27223183 chr8:87520930 FAM82B -0.55 -7.48 -0.38 6.8e-13 Caudate activity during reward; CRC trans rs9409565 0.826 rs2139189 chr9:97238538 A/G cg05679027 chr9:99775184 HIATL2 -0.43 -6.5 -0.34 2.91e-10 Colorectal cancer (alcohol consumption interaction); CRC cis rs10504229 0.679 rs17804870 chr8:58158071 A/G cg20607798 chr8:58055168 NA 0.55 5.91 0.31 8.36e-9 Developmental language disorder (linguistic errors); CRC cis rs6424115 0.830 rs2229585 chr1:24200921 T/C cg10978503 chr1:24200527 CNR2 0.61 11.06 0.52 2.22e-24 Immature fraction of reticulocytes; CRC cis rs2019137 0.967 rs902695 chr2:113955074 G/A cg21550016 chr2:113992930 PAX8;LOC440839;LOC654433 -0.51 -7.28 -0.37 2.46e-12 Lymphocyte counts; CRC cis rs11030122 0.702 rs10767713 chr11:3950157 T/C cg18678763 chr11:4115507 RRM1 -0.48 -7.95 -0.4 2.92e-14 Mean platelet volume;Platelet distribution width; CRC cis rs28386778 0.897 rs2727323 chr17:61921999 G/T cg23090583 chr17:61904693 PSMC5;FTSJ3 1.03 20.18 0.74 1.67e-59 Prudent dietary pattern; CRC cis rs6502050 0.835 rs4789672 chr17:80126603 T/C cg13198984 chr17:80129470 CCDC57 0.47 8.31 0.42 2.54e-15 Life satisfaction; CRC cis rs1552244 1.000 rs4260416 chr3:10125283 C/T cg10729496 chr3:10149963 C3orf24 0.51 6.89 0.35 2.92e-11 Alzheimer's disease; CRC cis rs9420 0.961 rs7936998 chr11:57639017 G/A cg23127183 chr11:57508653 C11orf31 -0.52 -6.82 -0.35 4.32e-11 Schizophrenia; CRC cis rs262150 0.630 rs2730274 chr7:158796062 C/A cg19418458 chr7:158789849 NA -0.49 -8.34 -0.42 2e-15 Facial morphology (factor 20); CRC trans rs1973993 0.691 rs2985636 chr1:96889884 T/A cg10631902 chr5:14652156 NA 0.62 12.56 0.57 7.84e-30 Weight; CRC trans rs853679 0.769 rs7752448 chr6:28301099 A/G cg06606381 chr12:133084897 FBRSL1 -0.89 -8.49 -0.42 7.05e-16 Depression; CRC cis rs4713118 0.662 rs13218430 chr6:28029837 T/C cg12273811 chr6:28175739 NA 0.62 8.22 0.41 4.78e-15 Parkinson's disease; CRC cis rs6951245 0.935 rs76525951 chr7:1096013 C/T cg18402987 chr7:1209562 NA 0.67 7.15 0.37 5.54e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC trans rs983332 0.512 rs6428657 chr1:88212380 C/T cg09221037 chr5:1523205 LPCAT1 -0.64 -6.05 -0.32 3.92e-9 Response to TNF antagonist treatment; CRC cis rs798554 0.679 rs7784066 chr7:2819727 T/A cg17321639 chr7:2759063 NA -0.44 -6.1 -0.32 2.96e-9 Height; CRC cis rs9291683 0.632 rs11734786 chr4:10041499 A/C cg11266682 chr4:10021025 SLC2A9 0.53 11.08 0.52 1.85e-24 Bone mineral density; CRC cis rs9297145 0.958 rs11975761 chr7:98766688 G/A cg05967295 chr7:98741636 SMURF1 -0.99 -17.1 -0.69 2.36e-47 Crohn's disease;Inflammatory bowel disease;Ulcerative colitis; CRC cis rs4654899 0.606 rs13376428 chr1:21120027 T/C cg02927042 chr1:21476669 EIF4G3 -0.37 -5.71 -0.3 2.47e-8 Superior frontal gyrus grey matter volume; CRC cis rs1580019 0.713 rs2167274 chr7:32524844 A/G cg07520158 chr7:32535189 LSM5;AVL9 0.54 7.74 0.39 1.26e-13 Cognitive ability; CRC cis rs7044106 0.762 rs10818471 chr9:123394045 A/G cg14255062 chr9:123606675 PSMD5;LOC253039 0.44 6.29 0.33 1.01e-9 Hip circumference adjusted for BMI; CRC cis rs2463822 0.507 rs72919442 chr11:62028707 A/G cg06239285 chr11:62104954 ASRGL1 -0.8 -7.67 -0.39 2e-13 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs8058578 1.000 rs6565201 chr16:30747191 C/T cg02466173 chr16:30829666 NA -0.76 -12.1 -0.55 4.09e-28 Multiple myeloma; CRC cis rs2882667 0.898 rs12719519 chr5:138375687 G/A cg04439458 chr5:138467593 SIL1 -0.33 -6.04 -0.32 4.07e-9 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs910316 0.870 rs7147712 chr14:75670707 C/G cg03030879 chr14:75389066 RPS6KL1 0.42 6.38 0.33 5.95e-10 Height; CRC cis rs9903692 0.862 rs12943543 chr17:46181365 A/T cg21215337 chr17:46176117 CBX1 -0.43 -7.95 -0.4 2.95e-14 Pulse pressure; CRC cis rs9527 0.571 rs10786715 chr10:104620735 G/C cg08772003 chr10:104629869 AS3MT -0.36 -6.11 -0.32 2.84e-9 Arsenic metabolism; CRC cis rs6120849 0.707 rs6088694 chr20:33652371 G/A cg08999081 chr20:33150536 PIGU 0.44 5.71 0.3 2.52e-8 Protein C levels; CRC cis rs1129187 0.967 rs9462857 chr6:42943098 T/C cg05552183 chr6:42928497 GNMT 0.6 9.55 0.47 3.1e-19 Alzheimer's disease in APOE e4+ carriers; CRC cis rs17166499 0.803 rs73070141 chr7:12897219 A/G cg12945054 chr7:12841881 NA 0.49 6.06 0.32 3.75e-9 Bipolar disorder and schizophrenia; CRC cis rs2629540 1.000 rs2629540 chr10:126426148 G/C cg08799069 chr10:126477246 METTL10 0.64 7.93 0.4 3.38e-14 Cocaine dependence; CRC trans rs9858542 0.953 rs9827708 chr3:49649989 C/G cg21659725 chr3:3221576 CRBN -0.71 -9.3 -0.46 1.95e-18 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs3996993 0.809 rs6932500 chr6:52665671 G/A cg20803780 chr6:52668592 GSTA1 0.35 6.37 0.33 6.23e-10 Hemoglobin concentration; CRC cis rs17234274 0.622 rs10833976 chr11:23221991 C/G cg05245346 chr11:23248277 NA 0.35 5.75 0.3 2.02e-8 Cancer; CRC cis rs644799 0.648 rs1255178 chr11:95471908 A/G cg25622487 chr11:95524042 FAM76B;CEP57 0.49 7.16 0.37 5.28e-12 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs4862750 0.914 rs9995391 chr4:187873749 A/T cg03452623 chr4:187889614 NA 0.87 18.96 0.72 1.04e-54 Lobe attachment (rater-scored or self-reported); CRC cis rs7274811 0.652 rs293732 chr20:31975090 G/A cg03904042 chr20:32255491 NECAB3;C20orf134 0.43 6.22 0.32 1.5e-9 Height; CRC trans rs1945213 0.694 rs11227181 chr11:55856053 C/T cg15704280 chr7:45808275 SEPT13 0.56 6.27 0.33 1.15e-9 Acute lymphoblastic leukemia (childhood); CRC cis rs3785574 0.962 rs2727329 chr17:61924566 C/T cg11494091 chr17:61959527 GH2 0.37 5.62 0.3 4.11e-8 Height; CRC trans rs10504390 0.585 rs117486340 chr8:66542077 G/A cg26403416 chr21:43771339 TFF2 0.6 6.14 0.32 2.38e-9 IgG glycosylation; CRC cis rs56104184 0.779 rs17272666 chr19:49356294 T/C cg15549821 chr19:49342101 PLEKHA4 -0.86 -10.13 -0.49 3.56e-21 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; CRC cis rs6952808 0.693 rs10950413 chr7:1912988 A/G cg23102388 chr7:1867652 MAD1L1 -0.31 -5.83 -0.31 1.34e-8 Bipolar disorder and schizophrenia; CRC cis rs1862618 0.526 rs2591963 chr5:56237135 T/A cg18230493 chr5:56204884 C5orf35 0.88 11.92 0.55 1.84e-27 Initial pursuit acceleration; CRC cis rs7705042 0.897 rs7718955 chr5:141521459 A/G cg08523384 chr5:141488047 NDFIP1 -0.32 -5.71 -0.3 2.5e-8 Asthma; CRC cis rs9811920 0.609 rs704583 chr3:99643693 A/G cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G 0.46 6.18 0.32 1.87e-9 Axial length; CRC cis rs8031584 0.918 rs34693097 chr15:31253984 A/G cg08109568 chr15:31115862 NA -0.54 -8.85 -0.44 5.62e-17 Huntington's disease progression; CRC cis rs7945705 0.774 rs6486060 chr11:9024630 A/G cg00186954 chr11:8933980 ST5;C11orf17 0.38 6.22 0.32 1.48e-9 Hemoglobin concentration; CRC cis rs6500602 0.563 rs917304 chr16:4440426 C/G cg08645402 chr16:4508243 NA 0.49 6.45 0.34 3.89e-10 Schizophrenia; CRC cis rs7940866 0.774 rs2162059 chr11:130831224 C/T cg12179176 chr11:130786555 SNX19 0.62 9.0 0.44 1.81e-17 Schizophrenia; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg08621418 chr6:79944414 HMGN3 0.42 6.36 0.33 6.74e-10 Liver disease severity in Alagille syndrome; CRC cis rs6933660 0.646 rs9397410 chr6:151770503 C/T cg02564969 chr6:151773285 C6orf211;RMND1 0.43 6.08 0.32 3.33e-9 Menarche (age at onset); CRC cis rs629535 0.821 rs680993 chr8:70050247 G/A cg26132723 chr8:70041827 NA 0.35 5.71 0.3 2.59e-8 Dupuytren's disease; CRC cis rs2652822 1.000 rs2652822 chr15:63422772 C/T cg02713581 chr15:63449717 RPS27L -0.39 -5.76 -0.3 1.95e-8 Metabolic traits; CRC cis rs10540 1.000 rs35996687 chr11:458595 G/A cg03576123 chr11:487126 PTDSS2 -1.11 -10.82 -0.51 1.51e-23 Body mass index; CRC cis rs875971 1.000 rs11971949 chr7:65626014 A/G cg18912574 chr7:65842487 NCRNA00174 -0.37 -6.4 -0.33 5.48e-10 Aortic root size; CRC cis rs3540 0.597 rs3539 chr15:91045419 G/T cg22089800 chr15:90895588 ZNF774 -0.57 -9.51 -0.46 4.26e-19 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; CRC cis rs62244186 0.566 rs6766221 chr3:44882784 C/T cg11003573 chr3:44754125 ZNF502 -0.33 -5.71 -0.3 2.51e-8 Depressive symptoms; CRC cis rs9814567 1.000 rs6793487 chr3:134299426 C/G cg06109529 chr3:134205091 CEP63;ANAPC13 0.81 11.69 0.54 1.24e-26 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs10256972 0.577 rs2949179 chr7:1209885 C/G cg26608667 chr7:1196370 ZFAND2A 0.42 6.86 0.35 3.4e-11 Longevity;Endometriosis; CRC cis rs9837602 0.507 rs1718244 chr3:99512608 C/T cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G -0.49 -6.49 -0.34 3.19e-10 Breast cancer; CRC cis rs2576037 0.526 rs4890707 chr18:44497724 C/G cg19077165 chr18:44547161 KATNAL2 -0.62 -10.44 -0.5 3.25e-22 Personality dimensions; CRC cis rs7727544 0.661 rs273900 chr5:131694606 G/A cg07395648 chr5:131743802 NA -0.4 -6.31 -0.33 9.05e-10 Blood metabolite levels; CRC cis rs3785574 0.962 rs2665842 chr17:61878535 G/A cg06601766 chr17:61851465 DDX42;CCDC47 0.61 8.68 0.43 1.83e-16 Height; CRC cis rs921968 0.541 rs667251 chr2:219384384 C/G cg02176678 chr2:219576539 TTLL4 0.54 8.69 0.43 1.78e-16 Mean corpuscular hemoglobin concentration; CRC cis rs736408 0.812 rs1076425 chr3:52825462 A/G cg18404041 chr3:52824283 ITIH1 -0.54 -10.75 -0.51 2.77e-23 Bipolar disorder; CRC cis rs2463822 0.669 rs72919493 chr11:62049651 C/A cg06239285 chr11:62104954 ASRGL1 -0.88 -8.64 -0.43 2.48e-16 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs4474465 0.850 rs10751294 chr11:78253303 T/A cg02023728 chr11:77925099 USP35 -0.37 -6.24 -0.33 1.33e-9 Alzheimer's disease (survival time); CRC cis rs1401999 0.714 rs1533683 chr3:183635488 C/T cg05044414 chr3:183734942 ABCC5 0.37 6.15 0.32 2.23e-9 Anterior chamber depth; CRC cis rs6963495 0.818 rs118134111 chr7:105161229 A/C cg02135003 chr7:105160482 PUS7 -0.9 -12.2 -0.56 1.71e-28 Bipolar disorder (body mass index interaction); CRC cis rs514406 0.565 rs897732 chr1:53382816 A/C cg24675658 chr1:53192096 ZYG11B -0.69 -10.07 -0.49 5.62e-21 Monocyte count; CRC cis rs801193 0.660 rs4610622 chr7:66224497 T/C cg18876405 chr7:65276391 NA 0.51 8.45 0.42 9.69e-16 Aortic root size; CRC cis rs6499129 0.558 rs16957489 chr16:67651879 G/A cg26727032 chr16:67993705 SLC12A4 -0.63 -7.89 -0.4 4.61e-14 Waist-to-hip ratio adjusted for body mass index; CRC cis rs2243480 1.000 rs4718316 chr7:65648731 A/G cg18252515 chr7:66147081 NA 1.23 14.37 0.62 1.07e-36 Diabetic kidney disease; CRC cis rs4664293 0.582 rs1046496 chr2:160473399 A/T cg08347373 chr2:160653686 CD302 -0.39 -6.54 -0.34 2.38e-10 Monocyte percentage of white cells; CRC cis rs7224685 0.501 rs6502770 chr17:4007314 A/G cg10724054 chr17:3904396 NA -0.37 -5.91 -0.31 8.32e-9 Type 2 diabetes; CRC cis rs7666738 0.830 rs13101766 chr4:98957696 C/A cg17366294 chr4:99064904 C4orf37 0.43 7.34 0.38 1.69e-12 Colonoscopy-negative controls vs population controls; CRC cis rs10782582 0.522 rs12125933 chr1:76130920 C/T cg03433033 chr1:76189801 ACADM -0.43 -6.17 -0.32 2.06e-9 Daytime sleep phenotypes; CRC cis rs736408 0.677 rs678 chr3:52820981 A/T cg10802521 chr3:52805072 NEK4 -0.54 -7.83 -0.4 6.56e-14 Bipolar disorder; CRC cis rs2019137 0.936 rs731834 chr2:113957198 A/C cg12889195 chr2:113992843 PAX8;LOC440839;LOC654433 -0.51 -7.23 -0.37 3.32e-12 Lymphocyte counts; CRC trans rs35110281 0.626 rs162367 chr21:44934857 A/G cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.41 6.47 0.34 3.5e-10 Mean corpuscular volume; CRC cis rs2033908 0.589 rs4757060 chr11:12842990 G/A cg25843174 chr11:12811716 TEAD1 -0.38 -6.73 -0.35 7.55e-11 Sitting height ratio; CRC cis rs9611565 0.659 rs4822036 chr22:41936019 A/G cg06481639 chr22:41940642 POLR3H -0.5 -5.8 -0.3 1.53e-8 Vitiligo; CRC cis rs11997175 0.574 rs4389890 chr8:33658018 C/T cg04338863 chr8:33670619 NA 0.38 6.52 0.34 2.66e-10 Body mass index; CRC cis rs1784581 0.894 rs1790001 chr6:162387504 G/T cg17173639 chr6:162384350 PARK2 -0.85 -15.13 -0.64 1.23e-39 Itch intensity from mosquito bite; CRC cis rs7901135 1.000 rs2393502 chr10:60560334 G/C cg23799393 chr10:60588674 BICC1 0.4 6.37 0.33 6.34e-10 Morning vs. evening chronotype; CRC cis rs651907 0.557 rs7651721 chr3:101393583 C/A cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.62 8.31 0.42 2.51e-15 Colorectal cancer; CRC cis rs13108904 0.901 rs13119532 chr4:1304505 G/C cg02018176 chr4:1364513 KIAA1530 0.43 7.03 0.36 1.23e-11 Obesity-related traits; CRC cis rs6662572 0.686 rs884443 chr1:46484421 G/C cg03123370 chr1:45965343 CCDC163P;MMACHC 0.46 5.9 0.31 8.81e-9 Blood protein levels; CRC cis rs6500395 0.962 rs1386042 chr16:48600332 G/A cg04672837 chr16:48644449 N4BP1 0.42 5.99 0.31 5.43e-9 Response to tocilizumab in rheumatoid arthritis; CRC cis rs8017423 0.647 rs4904677 chr14:90819245 C/T cg14092571 chr14:90743983 NA 0.39 5.94 0.31 7.29e-9 Mortality in heart failure; CRC cis rs853679 0.517 rs4713145 chr6:28106827 T/C cg12963246 chr6:28129442 ZNF389 0.49 5.78 0.3 1.73e-8 Depression; CRC cis rs4742903 0.967 rs4742904 chr9:106856952 C/T cg21169611 chr9:106856078 SMC2 0.44 6.11 0.32 2.75e-9 High-grade serous ovarian cancer;Breast cancer; CRC cis rs4604732 0.678 rs74154674 chr1:247625685 C/T cg12758973 chr1:247694275 LOC148824;OR2C3 0.42 6.14 0.32 2.32e-9 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CRC cis rs4930561 0.714 rs7126326 chr11:67947275 T/G cg04465784 chr11:67976953 SUV420H1 -0.3 -6.16 -0.32 2.12e-9 Breast cancer in childhood cancer survivors;IgG glycosylation; CRC cis rs9914988 0.943 rs66588554 chr17:27141110 A/G cg07195577 chr17:27052828 TLCD1 0.41 5.97 0.31 6.23e-9 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs9314323 0.798 rs12682345 chr8:26218332 A/G cg13160058 chr8:26243215 BNIP3L 0.47 7.66 0.39 2.03e-13 Red cell distribution width; CRC cis rs11112613 0.762 rs17037308 chr12:105949847 T/G cg03607813 chr12:105948248 NA 0.82 10.85 0.51 1.21e-23 Corrected insulin response;Corrected insulin response adjusted for insulin sensitivity index; CRC cis rs10504229 0.906 rs59336968 chr8:58176857 T/C cg02725872 chr8:58115012 NA -0.38 -6.43 -0.33 4.44e-10 Developmental language disorder (linguistic errors); CRC cis rs7659604 0.521 rs4833773 chr4:122689245 C/T cg19748678 chr4:122722346 EXOSC9 -0.43 -5.95 -0.31 6.72e-9 Type 2 diabetes; CRC cis rs2046867 0.818 rs34582798 chr3:72882778 A/C cg25664220 chr3:72788482 NA -0.46 -6.56 -0.34 2.1e-10 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; CRC cis rs8060686 0.641 rs28508024 chr16:68126606 T/C cg26727032 chr16:67993705 SLC12A4 -0.6 -8.12 -0.41 9.45e-15 HDL cholesterol;Metabolic syndrome; CRC cis rs4481887 0.927 rs4244181 chr1:248471118 A/G cg13385794 chr1:248469461 NA 0.36 6.34 0.33 7.63e-10 Common traits (Other); CRC cis rs9322817 0.691 rs12203954 chr6:105295647 C/T cg02098413 chr6:105308735 HACE1 0.44 8.7 0.43 1.61e-16 Thyroid stimulating hormone; CRC cis rs7727544 1.000 rs7727038 chr5:131590257 C/T cg04518342 chr5:131593106 PDLIM4 0.38 7.1 0.36 7.78e-12 Blood metabolite levels; CRC trans rs12663356 0.528 rs9350359 chr6:21462624 C/T cg09226173 chr5:122111107 SNX2 0.4 6.05 0.32 3.98e-9 Crohn's disease; CRC cis rs67478160 0.619 rs12878682 chr14:104233627 G/C cg01849466 chr14:104193079 ZFYVE21 -0.51 -9.14 -0.45 6.51e-18 Schizophrenia; CRC cis rs2777491 1.000 rs316613 chr15:41747598 G/A cg18705301 chr15:41695430 NDUFAF1 -0.74 -12.86 -0.58 6.05e-31 Ulcerative colitis; CRC cis rs3796352 1.000 rs35576914 chr3:53092270 G/A cg06204229 chr3:52865917 ITIH4 0.5 5.93 0.31 7.74e-9 Immune reponse to smallpox (secreted IL-2); CRC cis rs1448094 0.511 rs4469976 chr12:86146723 T/C cg06740227 chr12:86229804 RASSF9 -0.37 -5.64 -0.3 3.71e-8 Major depressive disorder; CRC cis rs12291225 0.585 rs12270374 chr11:14375079 T/C cg19336497 chr11:14380999 RRAS2 -0.52 -9.14 -0.45 6.51e-18 Sense of smell; CRC cis rs644148 0.967 rs613876 chr19:44968788 T/C cg15540054 chr19:45004280 ZNF180 -0.68 -9.59 -0.47 2.37e-19 Personality dimensions; CRC cis rs875971 0.502 rs11769702 chr7:65720516 A/C cg03233332 chr7:66118400 NA -0.43 -5.95 -0.31 6.75e-9 Aortic root size; CRC trans rs7618501 1.000 rs6446295 chr3:49809063 G/T cg21665057 chr3:196295764 WDR53;FBXO45 0.86 15.78 0.66 3.78e-42 Intelligence (multi-trait analysis); CRC cis rs4664293 0.867 rs3732289 chr2:160585398 G/C cg08347373 chr2:160653686 CD302 -0.47 -7.43 -0.38 9.32e-13 Monocyte percentage of white cells; CRC cis rs1957429 0.901 rs7141985 chr14:65345670 C/T cg23373153 chr14:65346875 NA 0.87 7.35 0.38 1.55e-12 Pediatric areal bone mineral density (radius); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg12598007 chr11:68607069 CPT1A 0.43 6.13 0.32 2.53e-9 Response to antipsychotic treatment; CRC cis rs6951245 0.554 rs11761322 chr7:1151657 A/G cg18402987 chr7:1209562 NA 0.55 6.77 0.35 6.03e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs812925 0.762 rs3213951 chr2:61622251 C/T cg10580144 chr2:61372316 C2orf74 0.3 6.12 0.32 2.61e-9 Immature fraction of reticulocytes; CRC cis rs317689 0.876 rs547332 chr12:69743639 C/G cg14784868 chr12:69753453 YEATS4 0.58 7.74 0.39 1.27e-13 Response to diuretic therapy; CRC cis rs7666738 0.753 rs7657644 chr4:99057734 T/A cg05340658 chr4:99064831 C4orf37 0.6 9.25 0.45 2.97e-18 Colonoscopy-negative controls vs population controls; CRC cis rs11105298 0.891 rs10858890 chr12:89907166 A/G cg08166232 chr12:89918718 WDR51B;GALNT4 -0.61 -7.81 -0.4 7.79e-14 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; CRC cis rs7937682 0.824 rs510866 chr11:111484113 A/C cg19812747 chr11:111475976 SIK2 -0.59 -10.14 -0.49 3.31e-21 Primary sclerosing cholangitis; CRC cis rs9649213 0.593 rs6465666 chr7:97937258 C/T cg24562669 chr7:97807699 LMTK2 -0.44 -7.48 -0.38 6.94e-13 Prostate cancer (SNP x SNP interaction); CRC cis rs6502050 0.805 rs56020943 chr17:80105248 C/A cg13198984 chr17:80129470 CCDC57 0.46 8.16 0.41 6.94e-15 Life satisfaction; CRC cis rs4862750 0.914 rs1346127 chr4:187876389 C/T cg06074448 chr4:187884817 NA 0.59 10.91 0.52 7.16e-24 Lobe attachment (rater-scored or self-reported); CRC cis rs9811920 0.609 rs7638900 chr3:99670773 T/C cg07805332 chr3:99536008 MIR548G;C3orf26 0.53 8.12 0.41 9.16e-15 Axial length; CRC cis rs7259376 0.840 rs8106611 chr19:22569618 G/A cg02657401 chr19:22469223 NA -0.31 -6.7 -0.35 9.22e-11 Menopause (age at onset); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg01269469 chr7:155090211 INSIG1 0.44 6.0 0.31 5.3300000000000004e-09 Response to antipsychotic treatment; CRC cis rs2739330 0.828 rs2186366 chr22:24254113 A/G cg23131131 chr22:24373011 LOC391322 0.65 10.27 0.49 1.16e-21 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs523522 0.962 rs2233676 chr12:120933607 G/A cg12219531 chr12:120966889 COQ5 0.69 9.31 0.46 1.85e-18 High light scatter reticulocyte count; CRC cis rs3820068 0.532 rs6701009 chr1:15935614 T/C cg24675056 chr1:15929824 NA 0.53 7.36 0.38 1.51e-12 Systolic blood pressure; CRC cis rs6952808 1.000 rs4256490 chr7:1890764 G/A cg00106254 chr7:1943704 MAD1L1 -0.45 -6.43 -0.33 4.47e-10 Bipolar disorder and schizophrenia; CRC cis rs1799949 0.965 rs12947782 chr17:41279882 A/G cg23758822 chr17:41437982 NA 0.79 13.46 0.6 3.47e-33 Menopause (age at onset); CRC cis rs1448094 0.512 rs2405632 chr12:86252456 A/G cg19622623 chr12:86230825 RASSF9 -0.41 -6.64 -0.34 1.28e-10 Major depressive disorder; CRC cis rs6951245 0.935 rs61753396 chr7:1105372 A/G cg18402987 chr7:1209562 NA 0.67 7.17 0.37 4.89e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs7020830 0.571 rs7031314 chr9:37376122 A/T cg14294708 chr9:37120828 ZCCHC7 -0.87 -12.19 -0.56 1.84e-28 Schizophrenia; CRC cis rs2120019 1.000 rs2415253 chr15:75375699 A/G cg09165964 chr15:75287851 SCAMP5 -0.8 -12.62 -0.57 4.86e-30 Blood trace element (Zn levels); CRC cis rs11112613 0.713 rs871220 chr12:105938558 G/A cg03607813 chr12:105948248 NA 0.74 9.57 0.47 2.68e-19 Corrected insulin response;Corrected insulin response adjusted for insulin sensitivity index; CRC cis rs11574514 1.000 rs11861657 chr16:67824395 A/G cg26727032 chr16:67993705 SLC12A4 -0.61 -6.02 -0.32 4.59e-9 Crohn's disease; CRC cis rs9487051 0.708 rs378447 chr6:109526823 G/A cg01475377 chr6:109611718 NA -0.34 -5.9 -0.31 8.95e-9 Reticulocyte fraction of red cells; CRC cis rs28386778 0.897 rs2727326 chr17:61923016 G/A cg06601766 chr17:61851465 DDX42;CCDC47 0.42 5.8 0.3 1.53e-8 Prudent dietary pattern; CRC cis rs3785574 1.000 rs7223257 chr17:61787684 T/C cg25654072 chr17:61904446 PSMC5;FTSJ3 0.43 5.99 0.31 5.38e-9 Height; CRC cis rs3087591 0.708 rs10445402 chr17:29661340 G/T cg24425628 chr17:29625626 OMG;NF1 0.73 13.21 0.59 3.03e-32 Hip circumference; CRC cis rs951366 1.000 rs951366 chr1:205685352 C/T cg26354017 chr1:205819088 PM20D1 0.44 6.38 0.33 5.94e-10 Menarche (age at onset); CRC cis rs6543140 0.964 rs1523205 chr2:103070176 G/T cg04239558 chr2:103089729 SLC9A4 0.37 6.61 0.34 1.53e-10 Blood protein levels; CRC cis rs9943753 0.508 rs5013021 chr12:109790752 C/A cg19025524 chr12:109796872 NA -0.56 -8.57 -0.43 4.05e-16 HDL cholesterol; CRC cis rs853679 0.517 rs9393885 chr6:28050009 A/T cg03623178 chr6:28175578 NA 0.92 12.19 0.56 1.91e-28 Depression; CRC trans rs2976388 0.647 rs2572906 chr8:143798269 G/A cg24628676 chr5:59189846 PDE4D -0.3 -6.03 -0.32 4.44e-9 Urinary tract infection frequency; CRC trans rs875971 0.502 rs1796227 chr7:66087019 G/C cg02869306 chr7:64672164 INTS4L1 0.42 6.01 0.31 4.85e-9 Aortic root size; CRC cis rs651907 0.535 rs13094753 chr3:101525082 A/G cg12386194 chr3:101231763 SENP7 0.52 7.45 0.38 8.46e-13 Colorectal cancer; CRC cis rs7659604 0.592 rs56077950 chr4:122721412 C/T cg20573242 chr4:122745356 CCNA2 0.53 7.62 0.39 2.65e-13 Type 2 diabetes; CRC cis rs9549367 0.713 rs3024761 chr13:113824090 C/G cg18105134 chr13:113819100 PROZ 0.84 12.58 0.57 6.99e-30 Platelet distribution width; CRC cis rs853679 0.517 rs4711164 chr6:28115156 C/T cg23161317 chr6:28129485 ZNF389 0.53 6.43 0.33 4.52e-10 Depression; CRC cis rs8070463 0.515 rs11655943 chr17:45385640 A/G cg25173405 chr17:45401733 C17orf57 -0.58 -9.8 -0.48 4.58e-20 Multiple sclerosis;Ankylosing spondylitis; CRC cis rs7618915 0.501 rs9917834 chr3:52634619 A/C cg11645453 chr3:52864694 ITIH4 0.36 6.48 0.34 3.43e-10 Bipolar disorder; CRC cis rs17234274 0.622 rs2170596 chr11:23234445 C/G cg05245346 chr11:23248277 NA 0.34 5.63 0.3 3.79e-8 Cancer; CRC cis rs8180040 0.764 rs11712716 chr3:47193432 T/C cg10298567 chr3:47292165 KIF9 -0.36 -5.77 -0.3 1.8e-8 Colorectal cancer; CRC cis rs1971762 0.545 rs7297461 chr12:54047178 A/T cg06632207 chr12:54070931 ATP5G2 0.48 8.39 0.42 1.49e-15 Height; CRC cis rs672059 0.513 rs627064 chr1:183165716 C/T cg01949993 chr1:183155116 LAMC2 -0.33 -5.8 -0.3 1.59e-8 Hypertriglyceridemia; CRC cis rs7605827 0.930 rs7608831 chr2:15605029 A/G cg19274914 chr2:15703543 NA 0.39 5.9 0.31 8.83e-9 Educational attainment (years of education); CRC cis rs12983728 0.505 rs12460050 chr19:58666109 G/A cg21294424 chr19:58662284 ZNF329 0.5 6.44 0.33 4.34e-10 Cholesterol, total; CRC trans rs492478 0.892 rs11950510 chr5:3943222 T/A cg09199442 chr11:28132951 METT5D1 -0.7 -6.1 -0.32 2.89e-9 Cognitive performance; CRC cis rs6735179 1.000 rs1124200 chr2:1778558 A/G cg19300414 chr2:1746591 PXDN 0.37 6.32 0.33 8.53e-10 Response to antipsychotic treatment; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg21083161 chr7:6388591 C7orf70 0.44 6.04 0.32 4.15e-9 Anxiety disorder; CRC cis rs3931020 0.530 rs12125889 chr1:75241971 A/G cg00121533 chr1:75199117 CRYZ;TYW3 0.51 6.88 0.35 3.01e-11 Resistin levels; CRC cis rs6500602 0.701 rs4785971 chr16:4577090 A/G cg08645402 chr16:4508243 NA 0.58 8.71 0.43 1.46e-16 Schizophrenia; CRC trans rs453301 0.571 rs2929454 chr8:9083854 A/C cg16141378 chr3:129829833 LOC729375 0.41 6.18 0.32 1.94e-9 Joint mobility (Beighton score); CRC cis rs2635047 0.967 rs2668786 chr18:44708472 A/G cg19077165 chr18:44547161 KATNAL2 -0.48 -7.92 -0.4 3.81e-14 Educational attainment; CRC cis rs7635838 0.859 rs9869977 chr3:11480081 C/A cg00170343 chr3:11313890 ATG7 0.42 6.37 0.33 6.23e-10 HDL cholesterol; CRC cis rs17826219 0.706 rs609472 chr17:28951427 T/C cg01831904 chr17:28903510 LRRC37B2 -0.56 -6.61 -0.34 1.56e-10 Body mass index; CRC cis rs796364 0.951 rs10931888 chr2:201022952 T/G cg12253985 chr2:200820533 C2orf60;C2orf47 -0.6 -6.25 -0.33 1.25e-9 Schizophrenia; CRC cis rs8072100 0.840 rs12453233 chr17:45454570 C/T cg08085267 chr17:45401833 C17orf57 -0.68 -11.22 -0.53 5.94e-25 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs2276314 0.857 rs59649576 chr18:33616075 G/T cg19628046 chr18:33552617 C18orf21 0.54 7.38 0.38 1.28e-12 Endometriosis;Drug-induced torsades de pointes; CRC cis rs9837602 1.000 rs7627991 chr3:99808338 A/G cg07805332 chr3:99536008 MIR548G;C3orf26 -0.47 -6.19 -0.32 1.74e-9 Breast cancer; CRC cis rs9926296 0.605 rs8047486 chr16:89854025 A/T cg21285383 chr16:89894308 SPIRE2 0.34 5.72 0.3 2.4e-8 Vitiligo; CRC cis rs11098499 0.739 rs2203039 chr4:120132347 T/C cg09307838 chr4:120376055 NA -0.53 -8.28 -0.42 3.1e-15 Corneal astigmatism; CRC cis rs13256369 1.000 rs10098234 chr8:8576692 G/A cg06671706 chr8:8559999 CLDN23 0.56 8.21 0.41 5.15e-15 Obesity-related traits; CRC trans rs4689592 0.513 rs4689586 chr4:7067413 A/G cg07817883 chr1:32538562 TMEM39B -0.63 -7.9 -0.4 4.1e-14 Monocyte percentage of white cells; CRC cis rs12497850 0.931 rs4974087 chr3:48919232 A/G cg07636037 chr3:49044803 WDR6 1.02 18.12 0.71 2.13e-51 Parkinson's disease; CRC trans rs924135 0.634 rs171583 chr16:16132332 A/G cg06794141 chr16:77535527 NA 0.41 6.12 0.32 2.65e-9 White blood cell count (basophil);Blood metabolite levels; CRC trans rs9858542 1.000 rs9823546 chr3:49705512 T/A cg21582582 chr3:182698605 DCUN1D1 -0.56 -6.83 -0.35 4.05e-11 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg10960666 chr17:33446614 RAD51L3 0.46 6.5 0.34 2.92e-10 Response to antipsychotic treatment; CRC cis rs11229555 0.645 rs10466679 chr11:58188257 T/C cg15696309 chr11:58395628 NA -0.82 -10.2 -0.49 2.15e-21 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; CRC cis rs2228479 0.850 rs62054638 chr16:89821131 G/C cg06656553 chr16:89960601 TCF25 -0.7 -5.76 -0.3 1.93e-8 Skin colour saturation; CRC trans rs8002861 0.641 rs2028813 chr13:44422126 G/T cg12856521 chr11:46389249 DGKZ 0.46 7.55 0.38 4.22e-13 Leprosy; CRC cis rs9399135 0.967 rs9376085 chr6:135371224 T/C cg22676075 chr6:135203613 NA 0.38 5.86 0.31 1.11e-8 Red blood cell count; CRC cis rs6545883 0.929 rs1209434 chr2:61672958 G/A cg15711740 chr2:61764176 XPO1 -0.42 -5.67 -0.3 3.18e-8 Tuberculosis; CRC cis rs17362650 0.653 rs12474647 chr2:9554280 A/T cg23886495 chr2:9695866 ADAM17 -0.47 -5.89 -0.31 9.69e-9 Alcohol dependence (age at onset); CRC cis rs4665809 0.556 rs1560869 chr2:26417095 T/C cg26119090 chr2:26468346 HADHA;HADHB -1.05 -15.29 -0.64 3.04e-40 Gut microbiome composition (summer); CRC cis rs7249142 0.597 rs7250650 chr19:19285989 A/T cg12558012 chr19:19281197 LOC729991-MEF2B;MEF2B 0.59 9.39 0.46 9.96e-19 IgG glycosylation; CRC trans rs2749592 0.531 rs1208559 chr10:38221370 T/C cg23533926 chr12:111358616 MYL2 0.47 6.83 0.35 4.16e-11 Age-related hearing impairment (SNP x SNP interaction); CRC trans rs61931739 0.517 rs10844738 chr12:34059503 T/A cg26384229 chr12:38710491 ALG10B 0.51 6.89 0.36 2.89e-11 Morning vs. evening chronotype; CRC cis rs9372498 0.536 rs12333080 chr6:118845410 A/C cg07617317 chr6:118971624 C6orf204 0.5 6.26 0.33 1.22e-9 Diastolic blood pressure; CRC cis rs644799 1.000 rs593665 chr11:95574302 A/G cg25478527 chr11:95522999 CEP57;FAM76B 0.52 7.81 0.4 7.95e-14 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs6951245 1.000 rs884977 chr7:1066410 T/C cg24642844 chr7:1081250 C7orf50 -0.58 -7.98 -0.4 2.47e-14 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs9486719 1.000 rs10457159 chr6:96993139 G/A cg06623918 chr6:96969491 KIAA0776 -0.82 -9.56 -0.47 2.8e-19 Migraine;Coronary artery disease; CRC cis rs2933343 0.729 rs6790091 chr3:128608751 G/C cg25356066 chr3:128598488 ACAD9 0.39 5.66 0.3 3.22e-8 IgG glycosylation; CRC cis rs60871478 0.730 rs13222476 chr7:826630 T/C cg05535760 chr7:792225 HEATR2 1.03 13.43 0.59 4.47e-33 Cerebrospinal P-tau181p levels; CRC cis rs921968 0.541 rs933994 chr2:219650616 C/T cg02176678 chr2:219576539 TTLL4 -0.42 -6.54 -0.34 2.36e-10 Mean corpuscular hemoglobin concentration; CRC cis rs7312933 0.645 rs12049942 chr12:42587052 G/A cg11827402 chr12:42719852 PPHLN1;ZCRB1 0.65 9.07 0.45 1.14e-17 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CRC cis rs2658782 0.789 rs2658775 chr11:93126799 C/T cg15737290 chr11:93063684 CCDC67 0.46 6.73 0.35 7.69e-11 Pulmonary function decline; CRC cis rs11098699 0.821 rs11731898 chr4:124220979 C/A cg09941581 chr4:124220074 SPATA5 0.43 6.39 0.33 5.51e-10 Mosquito bite size; CRC cis rs807669 0.868 rs762529 chr22:19170205 C/G cg02655711 chr22:19163373 SLC25A1 0.99 21.34 0.76 4.66e-64 Metabolite levels; CRC cis rs9372498 0.536 rs9489395 chr6:118758884 T/C cg07617317 chr6:118971624 C6orf204 0.52 6.47 0.34 3.53e-10 Diastolic blood pressure; CRC cis rs10207060 0.778 rs6543581 chr2:240702308 C/T cg07506560 chr2:240697449 NA -0.36 -5.72 -0.3 2.38e-8 Obesity-related traits; CRC cis rs1475911 1.000 rs12482477 chr21:43517233 T/A cg24372256 chr21:43528868 UMODL1;C21orf128 -0.59 -7.86 -0.4 5.58e-14 IgG glycosylation; CRC cis rs9311474 0.607 rs11711421 chr3:52561779 C/T cg05573699 chr3:52720067 GNL3;PBRM1 -0.41 -6.06 -0.32 3.78e-9 Electroencephalogram traits; CRC cis rs6540559 0.673 rs11805830 chr1:209984969 C/T cg25204440 chr1:209979598 IRF6 0.48 5.83 0.31 1.35e-8 Cleft lip with or without cleft palate; CRC cis rs4563143 0.647 rs73029014 chr19:29257655 G/C cg12667521 chr19:29218732 NA 0.49 7.49 0.38 6.26e-13 Methadone dose in opioid dependence; CRC cis rs947211 0.948 rs863725 chr1:205751196 C/T cg14893161 chr1:205819251 PM20D1 0.46 6.35 0.33 7.11e-10 Parkinson's disease; CRC cis rs9875589 0.957 rs60060718 chr3:13950333 G/A cg19554555 chr3:13937349 NA 0.52 7.45 0.38 8.21e-13 Ovarian reserve; CRC cis rs9469890 0.604 rs76452512 chr6:34504388 G/C cg17674042 chr6:34482479 PACSIN1 -0.66 -7.72 -0.39 1.4e-13 Pubertal anthropometrics;Coronary artery disease; CRC cis rs9403521 1.000 rs9403521 chr6:143994199 C/T cg18240653 chr6:144019428 PHACTR2 0.55 6.18 0.32 1.85e-9 Obesity-related traits; CRC cis rs11690935 0.788 rs6715929 chr2:172877507 A/G cg13550731 chr2:172543902 DYNC1I2 -0.87 -13.23 -0.59 2.44e-32 Schizophrenia; CRC cis rs66573146 0.831 rs67702333 chr4:6983040 C/G cg00086871 chr4:6988644 TBC1D14 1.01 8.53 0.43 5.54e-16 Granulocyte percentage of myeloid white cells; CRC cis rs6503525 0.701 rs28618095 chr17:38109075 T/C cg24910161 chr17:38119198 GSDMA -0.37 -5.97 -0.31 6.2e-9 Asthma; CRC cis rs7647973 1.000 rs7644148 chr3:49545241 G/A cg20833759 chr3:49053208 WDR6;DALRD3 -0.55 -8.02 -0.4 1.91e-14 Menarche (age at onset); CRC cis rs1552244 0.808 rs17032306 chr3:10091399 C/G cg16606324 chr3:10149918 C3orf24 0.7 9.66 0.47 1.31e-19 Alzheimer's disease; CRC cis rs270601 0.633 rs4535443 chr5:131572561 A/G cg12564285 chr5:131593104 PDLIM4 0.57 10.22 0.49 1.83e-21 Acylcarnitine levels; CRC trans rs2727020 0.702 rs609054 chr11:49219725 C/G cg15704280 chr7:45808275 SEPT13 0.86 14.88 0.63 1.18e-38 Coronary artery disease; CRC cis rs11645898 0.748 rs72787042 chr16:72067522 A/G cg14768367 chr16:72042858 DHODH -0.74 -7.66 -0.39 2.13e-13 Blood protein levels; CRC cis rs4728302 0.807 rs10226267 chr7:133601862 G/A cg03336402 chr7:133662267 EXOC4 -0.45 -6.51 -0.34 2.84e-10 Intelligence;Intelligence (multi-trait analysis); CRC cis rs68170813 0.559 rs79705824 chr7:106848325 T/C cg02696742 chr7:106810147 HBP1 -0.59 -6.42 -0.33 4.64e-10 Coronary artery disease; CRC cis rs67478160 0.619 rs10083367 chr14:104314183 C/G cg08213375 chr14:104286397 PPP1R13B -0.64 -13.32 -0.59 1.1e-32 Schizophrenia; CRC cis rs748404 0.697 rs498227 chr15:43573052 A/G cg02155558 chr15:43621948 ADAL;LCMT2 0.44 6.56 0.34 2.04e-10 Lung cancer; CRC cis rs3126085 0.935 rs11204937 chr1:152193851 C/T cg09127314 chr1:152161683 NA 0.52 6.81 0.35 4.79e-11 Atopic dermatitis; CRC cis rs11785400 1.000 rs4327844 chr8:143733540 C/T cg24634471 chr8:143751801 JRK -0.49 -7.13 -0.37 6.36e-12 Schizophrenia; CRC cis rs11971779 0.680 rs2355787 chr7:139089928 G/T cg23387468 chr7:139079360 LUC7L2 -0.42 -7.25 -0.37 2.96e-12 Diisocyanate-induced asthma; CRC cis rs853679 0.517 rs3823180 chr6:28061744 G/A cg18032046 chr6:28092343 ZSCAN16 -0.5 -5.84 -0.31 1.26e-8 Depression; CRC trans rs7618501 0.602 rs2245365 chr3:50097319 C/A cg21659725 chr3:3221576 CRBN -0.6 -9.47 -0.46 5.62e-19 Intelligence (multi-trait analysis); CRC cis rs7647973 0.516 rs4955419 chr3:49200692 T/A cg06212747 chr3:49208901 KLHDC8B 0.38 5.72 0.3 2.44e-8 Menarche (age at onset); CRC cis rs11958404 0.860 rs56090852 chr5:157431120 A/G cg05962755 chr5:157440814 NA 1.01 12.88 0.58 5.12e-31 IgG glycosylation; CRC cis rs875971 1.000 rs10244498 chr7:66116056 A/G cg18876405 chr7:65276391 NA 0.52 8.63 0.43 2.58e-16 Aortic root size; CRC cis rs1799949 1.000 rs1545764 chr17:41424565 G/A cg23758822 chr17:41437982 NA 0.82 13.67 0.6 5.17e-34 Menopause (age at onset); CRC cis rs7937682 0.889 rs551825 chr11:111480116 C/G cg09085632 chr11:111637200 PPP2R1B -0.98 -19.21 -0.73 1.09e-55 Primary sclerosing cholangitis; CRC cis rs1448094 0.511 rs10746353 chr12:86150146 A/T cg25456477 chr12:86230367 RASSF9 -0.36 -6.07 -0.32 3.43e-9 Major depressive disorder; CRC cis rs9916302 0.861 rs593480 chr17:37453780 A/C cg15445000 chr17:37608096 MED1 -0.41 -9.01 -0.44 1.72e-17 Glomerular filtration rate (creatinine); CRC cis rs4481887 0.508 rs6695316 chr1:248394322 G/C cg00666640 chr1:248458726 OR2T12 0.45 7.05 0.36 1.05e-11 Common traits (Other); CRC cis rs67311347 0.544 rs60329764 chr3:40334621 C/T cg09455208 chr3:40491958 NA -0.3 -6.06 -0.32 3.83e-9 Renal cell carcinoma; CRC cis rs9462027 0.628 rs2492860 chr6:34705530 C/A cg07306190 chr6:34760872 UHRF1BP1 -0.34 -6.07 -0.32 3.49e-9 Systemic lupus erythematosus; CRC cis rs56399783 0.901 rs79932907 chr7:2827901 C/G cg19731401 chr7:2775893 GNA12 0.67 7.3 0.37 2.25e-12 Childhood ear infection; CRC cis rs6502050 0.761 rs7225637 chr17:80059758 A/G cg22110888 chr17:80059540 CCDC57 0.43 6.66 0.34 1.17e-10 Life satisfaction; CRC cis rs3806843 0.547 rs246033 chr5:140332115 A/C cg19875535 chr5:140030758 IK 0.4 6.12 0.32 2.64e-9 Depressive symptoms (multi-trait analysis); CRC cis rs7586673 0.857 rs16845580 chr2:161920884 T/C cg22496339 chr2:162101262 NA 0.56 7.82 0.4 7.31e-14 Intelligence (multi-trait analysis); CRC cis rs6504622 0.875 rs4968250 chr17:45045351 C/G cg16759221 chr17:45003025 GOSR2 -0.54 -8.49 -0.42 7.18e-16 Orofacial clefts; CRC cis rs4731207 0.591 rs1471571 chr7:124650874 C/G cg23710748 chr7:124431027 NA -0.39 -6.25 -0.33 1.24e-9 Cutaneous malignant melanoma; CRC cis rs4930103 0.935 rs2071095 chr11:2020627 C/A cg23202291 chr11:1979235 NA 0.48 6.59 0.34 1.78e-10 DNA methylation (parent-of-origin);DNA methylation (variation); CRC cis rs6076065 0.748 rs2236023 chr20:23373043 A/C cg11657817 chr20:23433608 CST11 0.53 9.0 0.44 1.89e-17 Facial morphology (factor 15, philtrum width); CRC cis rs9818758 0.607 rs67060340 chr3:48915321 C/T cg00383909 chr3:49044727 WDR6 1.3 12.44 0.57 2.31e-29 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; CRC cis rs9311474 0.508 rs12637627 chr3:52619962 G/T cg10802521 chr3:52805072 NEK4 -0.57 -9.03 -0.45 1.5e-17 Electroencephalogram traits; CRC trans rs2676917 1.000 rs2676917 chr3:194737873 A/C cg23928234 chr4:184235706 WWC2 0.39 6.16 0.32 2.12e-9 Metabolite levels (Pyroglutamine); CRC cis rs736408 0.716 rs2300149 chr3:52822921 C/T cg15147215 chr3:52552868 STAB1 -0.59 -9.36 -0.46 1.26e-18 Bipolar disorder; CRC cis rs6502050 0.799 rs12940433 chr17:80120826 C/T cg02741985 chr17:80059408 CCDC57 0.43 7.15 0.37 5.59e-12 Life satisfaction; CRC cis rs12620999 0.878 rs7593514 chr2:237980691 A/G cg23555395 chr2:238036564 NA 0.58 9.42 0.46 8.38e-19 Systemic lupus erythematosus; CRC cis rs9969804 0.905 rs6479427 chr9:95428016 C/T cg14631576 chr9:95140430 CENPP 0.33 6.12 0.32 2.73e-9 Height; CRC cis rs7772486 0.875 rs7739418 chr6:146359188 G/A cg23711669 chr6:146136114 FBXO30 0.62 10.57 0.5 1.11e-22 Lobe attachment (rater-scored or self-reported); CRC cis rs9488822 0.676 rs1999929 chr6:116381994 T/C cg18764771 chr6:116381957 FRK 0.26 7.45 0.38 8.21e-13 Cholesterol, total;LDL cholesterol; CRC cis rs4363385 0.747 rs2339495 chr1:152975116 A/T cg25856811 chr1:152973957 SPRR3 -0.25 -6.76 -0.35 6.27e-11 Inflammatory skin disease; CRC cis rs2976388 0.590 rs13254346 chr8:143823863 G/C cg12516270 chr8:143859308 LYNX1 -0.39 -6.44 -0.33 4.17e-10 Urinary tract infection frequency; CRC trans rs10021731 0.692 rs10031142 chr4:115409589 G/A cg25927708 chr2:119603813 EN1 -0.33 -6.01 -0.31 4.92e-9 Optic disc area; CRC cis rs514406 0.505 rs269290 chr1:53167027 A/T cg08859206 chr1:53392774 SCP2 -0.39 -5.91 -0.31 8.48e-9 Monocyte count; CRC cis rs12477438 0.520 rs2516829 chr2:99773201 T/G cg14399236 chr2:99771627 LIPT1;TSGA10 0.78 13.46 0.6 3.28e-33 Chronic sinus infection; CRC cis rs10540 1.000 rs79808876 chr11:465763 C/A cg08200582 chr11:442649 ANO9 -0.69 -7.15 -0.37 5.65e-12 Body mass index; CRC cis rs7772486 0.597 rs7746618 chr6:146281367 T/C cg05347473 chr6:146136440 FBXO30 -0.49 -7.1 -0.36 7.59e-12 Lobe attachment (rater-scored or self-reported); CRC cis rs4319547 0.774 rs7295105 chr12:123124225 G/A cg05707623 chr12:122985044 ZCCHC8 -0.64 -8.27 -0.41 3.39e-15 Body mass index; CRC cis rs10751667 0.600 rs10751665 chr11:941300 G/A cg23136738 chr11:925521 AP2A2 -0.41 -6.73 -0.35 7.76e-11 Alzheimer's disease (late onset); CRC cis rs6700896 0.931 rs11208711 chr1:66147846 G/T cg04111102 chr1:66153794 NA 0.34 5.8 0.3 1.56e-8 C-reactive protein;Mean corpuscular volume;Mean corpuscular hemoglobin; CRC cis rs6714710 0.603 rs17488897 chr2:98365164 G/C cg26665480 chr2:98280029 ACTR1B 0.55 7.45 0.38 8.31e-13 Posterior cortical atrophy and Alzheimer's disease; CRC cis rs13191362 1.000 rs67487119 chr6:163102657 A/C cg06582575 chr6:163149167 PACRG;PARK2 0.93 11.85 0.55 3.25e-27 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg04464465 chr12:123755775 CDK2AP1 0.43 5.97 0.31 6.28e-9 Response to antipsychotic treatment; CRC cis rs9902453 1.000 rs9890205 chr17:28382704 C/T cg26525008 chr17:28256777 EFCAB5;SSH2 -0.59 -8.78 -0.44 8.99e-17 Coffee consumption (cups per day); CRC cis rs1728785 1.000 rs1645935 chr16:68563791 A/C cg02972257 chr16:68554789 NA -0.58 -7.08 -0.36 9.03e-12 Ulcerative colitis; CRC cis rs5750830 0.649 rs6001588 chr22:39819049 G/C cg11247378 chr22:39784982 NA -0.41 -7.4 -0.38 1.11e-12 Intelligence (multi-trait analysis); CRC cis rs4680 1.000 rs165656 chr22:19948863 C/G cg06346307 chr22:19949965 COMT -0.23 -5.93 -0.31 7.67e-9 Blood metabolite levels; CRC cis rs4663866 1.000 rs6741269 chr2:239179418 A/G cg16914508 chr2:239161102 PER2 0.77 7.86 0.4 5.51e-14 Irritable bowel syndrome; CRC cis rs9649213 0.593 rs6961438 chr7:98005849 T/C cg24562669 chr7:97807699 LMTK2 0.43 7.14 0.37 5.86e-12 Prostate cancer (SNP x SNP interaction); CRC cis rs6433857 0.657 rs6756509 chr2:181500273 T/C cg23363182 chr2:181467187 NA -0.58 -9.49 -0.46 5.01e-19 Body mass index; CRC cis rs12477438 0.520 rs2632276 chr2:99779655 C/A cg14399236 chr2:99771627 LIPT1;TSGA10 0.78 13.17 0.59 4.16e-32 Chronic sinus infection; CRC cis rs2120019 0.938 rs2289582 chr15:75310394 T/C cg11632617 chr15:75315747 PPCDC -0.53 -7.1 -0.36 7.9e-12 Blood trace element (Zn levels); CRC cis rs2279817 0.735 rs11203432 chr1:17991196 A/G cg21791023 chr1:18019539 ARHGEF10L -0.47 -5.67 -0.3 3.12e-8 Neuroticism; CRC cis rs4285028 0.948 rs35737776 chr3:121677856 G/A cg11130432 chr3:121712080 ILDR1 -0.52 -6.75 -0.35 6.81e-11 Multiple sclerosis; CRC cis rs66573146 0.572 rs67922134 chr4:6955772 G/A cg26116260 chr4:7069785 GRPEL1 -0.6 -5.81 -0.31 1.48e-8 Granulocyte percentage of myeloid white cells; CRC cis rs881375 0.678 rs2269060 chr9:123683569 C/T cg09419670 chr9:123605666 PSMD5;LOC253039 0.46 7.08 0.36 8.98e-12 Rheumatoid arthritis; CRC cis rs6694672 1.000 rs5997 chr1:197030201 T/C cg13682187 chr1:196946512 CFHR5 0.48 7.51 0.38 5.72e-13 Asthma; CRC cis rs2836974 0.897 rs1541102 chr21:40628765 C/T cg17971929 chr21:40555470 PSMG1 0.8 11.81 0.55 4.58e-27 Cognitive function; CRC cis rs1784581 0.588 rs9295179 chr6:162420546 G/A cg17173639 chr6:162384350 PARK2 0.61 9.88 0.48 2.43e-20 Itch intensity from mosquito bite; CRC cis rs2228479 0.571 rs62052183 chr16:89966921 C/A cg12064134 chr16:90016061 DEF8 -0.6 -5.6 -0.3 4.47e-8 Skin colour saturation; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg21211866 chr9:35111727 KIAA1539 0.51 6.63 0.34 1.35e-10 Thyroid stimulating hormone; CRC cis rs1192419 0.502 rs6681883 chr1:92054131 A/G cg24006770 chr1:92056542 NA 0.56 9.39 0.46 1.05e-18 Optic disc area;Optic nerve measurement (cup-to-disc ratio); CRC cis rs9611565 0.614 rs4822053 chr22:42212936 C/A cg03806693 chr22:41940476 POLR3H -0.67 -9.21 -0.45 3.84e-18 Vitiligo; CRC cis rs6502050 0.835 rs8081783 chr17:80117388 G/A cg02741985 chr17:80059408 CCDC57 0.43 7.18 0.37 4.57e-12 Life satisfaction; CRC cis rs7659604 1.000 rs6846232 chr4:122664805 A/G cg20573242 chr4:122745356 CCNA2 0.4 6.0 0.31 5.17e-9 Type 2 diabetes; CRC cis rs7923452 0.507 rs215494 chr10:30776589 T/G cg18806716 chr10:30721971 MAP3K8 -0.54 -7.33 -0.37 1.85e-12 Itch intensity from mosquito bite; CRC cis rs2735413 0.837 rs4888734 chr16:78083685 C/G cg04733911 chr16:78082701 NA -0.45 -7.42 -0.38 1.03e-12 Systolic blood pressure (alcohol consumption interaction); CRC cis rs6952808 0.689 rs58227534 chr7:2046328 A/G cg00106254 chr7:1943704 MAD1L1 -0.53 -7.74 -0.39 1.24e-13 Bipolar disorder and schizophrenia; CRC cis rs3741151 0.892 rs7102787 chr11:73012614 A/G cg17517138 chr11:73019481 ARHGEF17 0.69 7.28 0.37 2.48e-12 GIP levels in response to oral glucose tolerance test (120 minutes); CRC trans rs1901167 1.000 rs3828509 chr5:40961873 A/G cg07701837 chr2:210516795 MAP2 0.37 5.98 0.31 5.85e-9 Cerebrospinal fluid biomarker levels; CRC cis rs6089584 0.962 rs6142913 chr20:60566950 A/G cg13770153 chr20:60521292 NA -0.57 -9.14 -0.45 6.68e-18 Body mass index; CRC cis rs910316 0.737 rs398896 chr14:75482827 C/A cg03030879 chr14:75389066 RPS6KL1 0.43 6.54 0.34 2.35e-10 Height; CRC cis rs9875589 0.509 rs4685062 chr3:14066409 T/C cg14375111 chr3:14165186 TMEM43;CHCHD4 0.41 6.13 0.32 2.46e-9 Ovarian reserve; CRC cis rs7633770 0.769 rs2385858 chr3:46660436 T/C cg11219411 chr3:46661640 NA 0.74 13.39 0.59 5.98e-33 Coronary artery disease; CRC cis rs12893668 0.616 rs58033365 chr14:104030901 T/C cg08213375 chr14:104286397 PPP1R13B 0.37 5.79 0.3 1.66e-8 Reticulocyte count; CRC cis rs12620999 0.555 rs4073396 chr2:238111471 A/C cg23555395 chr2:238036564 NA 0.44 7.19 0.37 4.34e-12 Systemic lupus erythematosus; CRC cis rs12291225 0.679 rs11605531 chr11:14291594 A/G cg05501817 chr11:14380813 RRAS2 -0.45 -5.94 -0.31 7.15e-9 Sense of smell; CRC cis rs11247915 0.561 rs11583258 chr1:26624270 C/T cg04990556 chr1:26633338 UBXN11 -0.49 -5.79 -0.3 1.61e-8 Obesity-related traits; CRC cis rs798766 0.723 rs3134865 chr4:1723279 T/C cg05874882 chr4:1763078 NA -0.36 -6.62 -0.34 1.5e-10 Bladder cancer;Urinary bladder cancer; CRC cis rs875971 0.545 rs73152714 chr7:65999628 G/A cg05627663 chr7:65219948 SNORA22;CCT6P1 0.56 7.25 0.37 3.06e-12 Aortic root size; CRC cis rs599083 0.530 rs667126 chr11:68177728 C/T cg01657329 chr11:68192670 LRP5 0.47 6.89 0.36 2.78e-11 Bone mineral density (spine); CRC cis rs17095355 1.000 rs55683820 chr10:111665376 G/A cg00817464 chr10:111662876 XPNPEP1 -0.53 -6.07 -0.32 3.43e-9 Biliary atresia; CRC cis rs3760982 1.000 rs3760982 chr19:44286513 A/G cg12072164 chr19:44306565 LYPD5 0.41 6.5 0.34 2.89e-10 Breast cancer (estrogen-receptor negative);Breast cancer; CRC cis rs11122272 0.701 rs11582413 chr1:231530098 C/G cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.58 -8.75 -0.43 1.1e-16 Hemoglobin concentration; CRC cis rs2481665 0.740 rs2457831 chr1:62633581 C/T cg18591186 chr1:62594603 INADL 0.45 6.45 0.33 4.02e-10 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs8170 1.000 rs73509996 chr19:17393449 T/G cg04749549 chr19:17459798 NA -0.46 -6.16 -0.32 2.13e-9 Breast cancer (estrogen-receptor negative);Breast Cancer in BRCA1 mutation carriers;Ovarian cancer;Breast cancer;Epithelial ovarian cancer; CRC trans rs7615952 0.800 rs13086460 chr3:125646417 C/T cg00769240 chr8:12517080 NA -0.57 -7.09 -0.36 8.4e-12 Blood pressure (smoking interaction); CRC cis rs875971 0.929 rs34406470 chr7:65929956 A/G cg18912574 chr7:65842487 NCRNA00174 0.35 5.87 0.31 1.05e-8 Aortic root size; CRC cis rs6665290 0.935 rs1929863 chr1:227195728 C/T cg10327440 chr1:227177885 CDC42BPA -1.05 -23.78 -0.8 1.85e-73 Myeloid white cell count; CRC cis rs1670533 1.000 rs7685541 chr4:1058501 G/A cg27284194 chr4:1044797 NA 0.5 6.2 0.32 1.66e-9 Recombination rate (females); CRC trans rs35110281 0.714 rs2282526 chr21:45080552 A/T cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.53 8.92 0.44 3.28e-17 Mean corpuscular volume; CRC cis rs1448094 0.549 rs10863085 chr12:86236328 G/A cg00310523 chr12:86230176 RASSF9 0.35 5.87 0.31 1.07e-8 Major depressive disorder; CRC cis rs6502050 0.814 rs62079997 chr17:80076888 C/T cg09264619 chr17:80180166 NA 0.36 5.92 0.31 8.22e-9 Life satisfaction; CRC cis rs62408225 0.894 rs4707609 chr6:90946479 T/C cg06866423 chr6:90926672 BACH2 0.44 7.12 0.37 6.97e-12 Eosinophil counts;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC cis rs12971120 0.891 rs3794955 chr18:72174827 C/T cg25817165 chr18:72167213 CNDP2 -0.62 -8.3 -0.42 2.78e-15 Refractive error; CRC cis rs4819052 1.000 rs2297286 chr21:46707897 C/G cg11663144 chr21:46675770 NA -0.77 -10.93 -0.52 6.36e-24 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs4713118 0.955 rs9468206 chr6:27690453 G/T cg25164649 chr6:28176230 NA 0.55 7.41 0.38 1.1e-12 Parkinson's disease; CRC cis rs6502050 0.805 rs7503095 chr17:80107354 G/A cg19223190 chr17:80058835 NA 0.4 6.36 0.33 6.88e-10 Life satisfaction; CRC trans rs1005277 0.579 rs2474595 chr10:38426782 C/G cg23533926 chr12:111358616 MYL2 0.52 7.74 0.39 1.27e-13 Extrinsic epigenetic age acceleration; CRC cis rs951366 0.789 rs864783 chr1:205711974 T/C cg07167872 chr1:205819463 PM20D1 0.76 11.47 0.53 7.42e-26 Menarche (age at onset); CRC cis rs56104184 0.775 rs73061699 chr19:49400511 T/C cg21252483 chr19:49399788 TULP2 -0.43 -6.62 -0.34 1.49e-10 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; CRC cis rs7703744 0.634 rs73237292 chr5:118688520 A/T cg17471836 chr5:118691007 TNFAIP8 0.42 5.91 0.31 8.71e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs4363385 0.818 rs61811862 chr1:152995668 G/A cg25856811 chr1:152973957 SPRR3 -0.24 -6.73 -0.35 7.68e-11 Inflammatory skin disease; CRC cis rs208515 0.525 rs10944869 chr6:66687576 G/T cg07460842 chr6:66804631 NA 0.94 11.8 0.55 5e-27 Exhaled nitric oxide levels; CRC cis rs7309 0.935 rs6432674 chr2:162025322 G/T cg08807892 chr2:162101083 NA 0.45 6.64 0.34 1.3100000000000001e-10 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Educational attainment; CRC cis rs1448094 0.512 rs6539929 chr12:86244932 T/C cg25456477 chr12:86230367 RASSF9 0.32 5.63 0.3 3.86e-8 Major depressive disorder; CRC cis rs6952808 0.609 rs6950151 chr7:1953521 T/C cg04267008 chr7:1944627 MAD1L1 -0.63 -9.72 -0.47 8.69e-20 Bipolar disorder and schizophrenia; CRC cis rs9487051 0.676 rs2222392 chr6:109602303 T/C cg21918786 chr6:109611834 NA -0.42 -7.4 -0.38 1.13e-12 Reticulocyte fraction of red cells; CRC cis rs2635047 0.756 rs34939493 chr18:44795621 G/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.36 5.73 0.3 2.24e-8 Educational attainment; CRC cis rs6503525 0.591 rs8080734 chr17:38103285 G/A cg04756853 chr17:38118787 GSDMA -0.38 -5.81 -0.3 1.49e-8 Asthma; CRC cis rs514406 0.505 rs12726160 chr1:53175099 A/G cg25767906 chr1:53392781 SCP2 -0.39 -6.17 -0.32 2.01e-9 Monocyte count; CRC cis rs10888329 0.744 rs4916082 chr1:248367415 C/T cg00666640 chr1:248458726 OR2T12 0.43 6.96 0.36 1.8e-11 Autism spectrum disorder; CRC cis rs4332037 0.707 rs10268797 chr7:1873756 C/G cg21155852 chr7:2048760 MAD1L1 0.42 5.89 0.31 9.57e-9 Bipolar disorder; CRC cis rs7618915 0.547 rs62253703 chr3:52632357 T/C cg07507251 chr3:52567010 NT5DC2 0.42 6.06 0.32 3.62e-9 Bipolar disorder; CRC cis rs1218582 0.661 rs4845695 chr1:154911798 A/G cg03351412 chr1:154909251 PMVK 0.51 7.22 0.37 3.73e-12 Prostate cancer; CRC cis rs3741151 0.773 rs57354084 chr11:73139376 A/T cg17517138 chr11:73019481 ARHGEF17 0.92 7.7 0.39 1.63e-13 GIP levels in response to oral glucose tolerance test (120 minutes); CRC cis rs172166 0.694 rs1225716 chr6:28113746 A/C cg06470822 chr6:28175283 NA 0.82 12.06 0.55 5.37e-28 Cardiac Troponin-T levels; CRC trans rs12200782 0.649 rs9467743 chr6:26386506 T/G cg25800765 chr12:85673347 ALX1 0.26 5.96 0.31 6.54e-9 Small cell lung carcinoma; CRC cis rs7726414 1.000 rs115808154 chr5:133464275 A/G cg11781344 chr5:133706657 UBE2B 0.68 6.92 0.36 2.41e-11 Systemic lupus erythematosus; CRC cis rs422249 0.512 rs174554 chr11:61579463 A/G cg00603274 chr11:61596626 FADS2 -0.44 -6.4 -0.33 5.33e-10 Trans fatty acid levels; CRC cis rs2576037 0.526 rs1893427 chr18:44434987 C/T cg23996704 chr18:44553084 KATNAL2 -0.35 -7.16 -0.37 5.38e-12 Personality dimensions; CRC cis rs1799949 0.930 rs8176194 chr17:41231221 A/C cg23758822 chr17:41437982 NA 0.82 13.6 0.6 9.77e-34 Menopause (age at onset); CRC cis rs3806843 0.551 rs246018 chr5:140335043 T/C cg19875535 chr5:140030758 IK 0.4 6.12 0.32 2.64e-9 Depressive symptoms (multi-trait analysis); CRC trans rs7615952 0.515 rs4267608 chr3:125680500 C/T cg07211511 chr3:129823064 LOC729375 -0.63 -8.65 -0.43 2.28e-16 Blood pressure (smoking interaction); CRC cis rs11098499 0.874 rs10022508 chr4:120115228 A/G cg24375607 chr4:120327624 NA 0.48 7.28 0.37 2.43e-12 Corneal astigmatism; CRC cis rs755249 0.567 rs16826093 chr1:39815143 T/A cg18385671 chr1:39797026 MACF1 -0.41 -5.77 -0.3 1.81e-8 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs668210 0.793 rs506873 chr11:65767215 A/C cg02202077 chr11:65769826 EIF1AD;BANF1 -0.45 -6.01 -0.31 4.94e-9 Cerebrospinal fluid biomarker levels; CRC cis rs5753618 0.561 rs737684 chr22:31659827 C/G cg22777020 chr22:31556080 RNF185 -0.52 -5.97 -0.31 6.27e-9 Colorectal cancer; CRC cis rs2952156 0.959 rs1565922 chr17:37831035 A/G cg00129232 chr17:37814104 STARD3 -0.69 -11.59 -0.54 2.73e-26 Asthma; CRC cis rs950169 0.959 rs12902070 chr15:84793558 T/C cg11189052 chr15:85197271 WDR73 0.62 9.12 0.45 7.59e-18 Schizophrenia; CRC trans rs11039798 0.512 rs1588069 chr11:48694871 A/G cg15704280 chr7:45808275 SEPT13 0.66 6.81 0.35 4.72e-11 Axial length; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg02360337 chr11:65627185 MUS81;CFL1 0.48 6.6 0.34 1.68e-10 Response to antipsychotic treatment; CRC cis rs4332037 0.851 rs73050128 chr7:1961882 C/A cg21155852 chr7:2048760 MAD1L1 -0.5 -6.72 -0.35 8.2e-11 Bipolar disorder; CRC cis rs3789045 1.000 rs45501495 chr1:204596454 C/T cg17419461 chr1:204415978 PIK3C2B -0.45 -7.01 -0.36 1.34e-11 Educational attainment (college completion); CRC trans rs7615952 0.688 rs17334074 chr3:125540460 A/G cg07211511 chr3:129823064 LOC729375 0.89 13.4 0.59 5.88e-33 Blood pressure (smoking interaction); CRC cis rs10876993 0.893 rs1678504 chr12:58085498 G/C cg15848620 chr12:58087721 OS9 -0.66 -9.19 -0.45 4.44e-18 Celiac disease or Rheumatoid arthritis; CRC cis rs524281 0.814 rs1055615 chr11:65846922 C/G cg16950941 chr11:66035639 RAB1B -0.61 -7.65 -0.39 2.25e-13 Electroencephalogram traits; CRC cis rs6586163 0.872 rs1800682 chr10:90749963 A/G cg13456138 chr10:90753195 FAS -0.4 -6.15 -0.32 2.19e-9 Chronic lymphocytic leukemia; CRC cis rs853679 0.517 rs17774663 chr6:28120898 G/A cg06470822 chr6:28175283 NA 1.03 13.59 0.6 1.04e-33 Depression; CRC cis rs7666738 0.830 rs13328005 chr4:99055480 T/C cg17366294 chr4:99064904 C4orf37 0.44 7.37 0.38 1.37e-12 Colonoscopy-negative controls vs population controls; CRC cis rs2949837 0.581 rs1496499 chr7:45979023 T/G cg04796162 chr7:45961102 IGFBP3 0.4 6.86 0.35 3.4e-11 Sitting height ratio; CRC cis rs60871478 0.588 rs56205589 chr7:910419 G/A cg05535760 chr7:792225 HEATR2 -0.89 -10.02 -0.48 8.61e-21 Cerebrospinal P-tau181p levels; CRC cis rs4665809 1.000 rs2891490 chr2:26325927 T/C cg04944784 chr2:26401820 FAM59B -0.6 -7.66 -0.39 2.09e-13 Gut microbiome composition (summer); CRC cis rs6424115 0.830 rs2503000 chr1:24197898 C/G cg10978503 chr1:24200527 CNR2 0.6 11.12 0.52 1.31e-24 Immature fraction of reticulocytes; CRC cis rs1153858 1.000 rs4774578 chr15:45646051 G/A cg21132104 chr15:45694354 SPATA5L1 0.59 8.71 0.43 1.49e-16 Homoarginine levels; CRC trans rs7267979 1.000 rs2257496 chr20:25279315 A/G cg17903999 chr18:56338584 MALT1 -0.42 -6.99 -0.36 1.52e-11 Liver enzyme levels (alkaline phosphatase); CRC cis rs17095355 1.000 rs12571872 chr10:111676114 G/A cg00817464 chr10:111662876 XPNPEP1 -0.53 -6.03 -0.32 4.49e-9 Biliary atresia; CRC cis rs763121 0.853 rs5757162 chr22:38993370 C/T cg06544989 chr22:39130855 UNC84B 0.43 6.32 0.33 8.54e-10 Menopause (age at onset); CRC cis rs7917772 0.503 rs7914389 chr10:104295402 T/C cg22532475 chr10:104410764 TRIM8 -0.36 -6.8 -0.35 5.08e-11 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC trans rs2727020 0.576 rs10839305 chr11:49598733 T/C cg21153622 chr11:89784906 NA -0.37 -5.96 -0.31 6.37e-9 Coronary artery disease; CRC cis rs7394190 0.748 rs60212594 chr10:75414344 G/C cg07699608 chr10:75541558 CHCHD1 0.59 6.08 0.32 3.34e-9 Incident atrial fibrillation; CRC cis rs7932354 0.528 rs7479189 chr11:47057009 T/A cg19486271 chr11:47235900 DDB2 -0.42 -6.22 -0.32 1.52e-9 Bone mineral density (hip);Bone mineral density; CRC cis rs7666738 0.830 rs28456179 chr4:98991439 A/G cg05340658 chr4:99064831 C4orf37 0.61 9.47 0.46 5.47e-19 Colonoscopy-negative controls vs population controls; CRC cis rs6963495 0.818 rs711430 chr7:105167969 A/G cg02135003 chr7:105160482 PUS7 -0.7 -10.33 -0.49 7.7e-22 Bipolar disorder (body mass index interaction); CRC cis rs8005677 1.000 rs4981449 chr14:23388871 C/G cg01529538 chr14:23388837 RBM23 0.4 6.18 0.32 1.86e-9 Cognitive ability (multi-trait analysis); CRC cis rs7727544 1.000 rs7727544 chr5:131590534 C/T cg09877947 chr5:131593287 PDLIM4 0.38 7.21 0.37 3.96e-12 Blood metabolite levels; CRC cis rs11997175 0.646 rs4593495 chr8:33692649 C/T cg04338863 chr8:33670619 NA 0.43 6.76 0.35 6.28e-11 Body mass index; CRC cis rs13031619 0.660 rs34855424 chr2:3702780 C/A cg10645314 chr2:3704589 ALLC -0.88 -10.39 -0.5 4.67e-22 Response to inhaled corticosteroid treatment in asthma (change in FEV1); CRC cis rs2565722 0.714 rs78851647 chr6:161276950 C/T cg03159191 chr6:161285451 NA -0.46 -5.66 -0.3 3.36e-8 Blood protein levels; CRC cis rs926938 0.765 rs2268701 chr1:115233046 C/T cg12756093 chr1:115239321 AMPD1 -0.66 -10.06 -0.49 6.04e-21 Autism; CRC cis rs1223397 0.938 rs3817738 chr6:13279388 G/T cg07912922 chr6:13274314 PHACTR1 0.56 6.53 0.34 2.46e-10 Blood pressure; CRC cis rs116095464 0.558 rs59113266 chr5:279965 T/C cg22857025 chr5:266934 NA -1.24 -16.52 -0.67 4.4e-45 Breast cancer; CRC cis rs9611565 0.694 rs5758365 chr22:41858657 A/G cg06481639 chr22:41940642 POLR3H 0.51 6.06 0.32 3.79e-9 Vitiligo; CRC cis rs2298450 0.717 rs2835328 chr21:37622915 A/C cg02919814 chr21:37666008 DOPEY2 -0.49 -6.5 -0.34 2.96e-10 Schizophrenia; CRC cis rs904251 0.523 rs12202055 chr6:37486080 A/T cg25019722 chr6:37503610 NA -0.4 -7.13 -0.37 6.42e-12 Cognitive performance; CRC cis rs7274811 0.652 rs293732 chr20:31975090 G/A cg07470512 chr20:32255052 NECAB3;C20orf134 0.43 5.83 0.31 1.29e-8 Height; CRC cis rs7591163 0.883 rs16824023 chr2:228720877 G/A cg21577049 chr2:228736449 WDR69 -0.44 -6.2 -0.32 1.65e-9 Blood pressure; CRC cis rs637571 0.522 rs566590 chr11:65754062 C/T cg17985854 chr11:65770987 BANF1;EIF1AD 0.51 8.62 0.43 2.79e-16 Eosinophil percentage of white cells; CRC cis rs4332037 0.906 rs6461009 chr7:1952139 T/C cg02421172 chr7:1938701 MAD1L1 -0.44 -6.15 -0.32 2.29e-9 Bipolar disorder; CRC cis rs12760731 0.641 rs12038910 chr1:178444907 C/T cg00404053 chr1:178313656 RASAL2 0.87 9.36 0.46 1.27e-18 Obesity-related traits; CRC cis rs1799949 0.929 rs799906 chr17:41278116 T/C cg25072359 chr17:41440525 NA 0.52 8.33 0.42 2.24e-15 Menopause (age at onset); CRC cis rs9905704 0.914 rs2643120 chr17:56826949 A/T cg12560992 chr17:57184187 TRIM37 0.53 7.29 0.37 2.33e-12 Testicular germ cell tumor; CRC cis rs10504229 1.000 rs67546820 chr8:58168567 G/A cg05313129 chr8:58192883 C8orf71 -0.47 -7.26 -0.37 2.8e-12 Developmental language disorder (linguistic errors); CRC cis rs4713118 0.869 rs6456802 chr6:27698355 A/G cg12172441 chr6:28176163 NA 0.52 7.19 0.37 4.51e-12 Parkinson's disease; CRC cis rs3617 0.652 rs7630552 chr3:52891570 G/C cg18099408 chr3:52552593 STAB1 0.34 5.87 0.31 1.06e-8 Red blood cell count;Autism spectrum disorder or schizophrenia; CRC cis rs9372498 0.505 rs62424202 chr6:118851027 T/C cg15382696 chr6:118971807 C6orf204 0.58 7.38 0.38 1.32e-12 Diastolic blood pressure; CRC trans rs62295889 0.673 rs62293666 chr4:12538889 G/C cg03490839 chr16:73082051 ZFHX3 0.58 6.06 0.32 3.82e-9 Obesity-related traits; CRC cis rs73200209 0.912 rs57109552 chr12:116657460 T/C cg01776926 chr12:116560359 MED13L -0.48 -5.78 -0.3 1.72e-8 Total body bone mineral density; CRC trans rs4650994 0.525 rs2761463 chr1:178557137 T/C cg05059571 chr16:84539110 KIAA1609 0.63 8.68 0.43 1.91e-16 HDL cholesterol levels;HDL cholesterol; CRC cis rs7727544 0.716 rs2089855 chr5:131573529 A/G cg04518342 chr5:131593106 PDLIM4 0.35 6.31 0.33 9.18e-10 Blood metabolite levels; CRC trans rs10504229 1.000 rs66731170 chr8:58187895 C/G cg04077850 chr5:125800366 GRAMD3 0.37 6.27 0.33 1.15e-9 Developmental language disorder (linguistic errors); CRC cis rs4713118 0.869 rs9468214 chr6:27713299 G/C cg26587870 chr6:27730563 NA -0.44 -6.73 -0.35 7.39e-11 Parkinson's disease; CRC cis rs1448094 0.511 rs61930587 chr12:86158793 T/C cg25456477 chr12:86230367 RASSF9 0.4 6.61 0.34 1.51e-10 Major depressive disorder; CRC cis rs12922317 0.589 rs7192491 chr16:12144026 T/C cg02368508 chr16:12060182 TNFRSF17 -0.41 -6.04 -0.32 4.08e-9 Schizophrenia; CRC cis rs11105298 0.891 rs10858902 chr12:89927789 A/G cg00757033 chr12:89920650 WDR51B 0.38 6.35 0.33 7.15e-10 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; CRC cis rs10779751 1.000 rs2076655 chr1:11289161 A/G cg08854313 chr1:11322531 MTOR -0.79 -12.65 -0.57 3.72e-30 Body mass index; CRC cis rs262150 0.659 rs2527236 chr7:158796644 C/T cg12590608 chr7:158785262 NA 0.37 6.47 0.34 3.56e-10 Facial morphology (factor 20); CRC cis rs6089584 0.816 rs6061410 chr20:60625329 A/G cg06108461 chr20:60628389 TAF4 -0.91 -15.7 -0.65 7.66e-42 Body mass index; CRC cis rs2836974 0.863 rs6517519 chr21:40540245 A/G cg17971929 chr21:40555470 PSMG1 0.81 11.93 0.55 1.61e-27 Cognitive function; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg03689120 chr13:20767179 GJB2 -0.4 -6.13 -0.32 2.55e-9 Myopia (pathological); CRC cis rs10256972 0.591 rs6950319 chr7:1161324 A/G cg27094323 chr7:1216898 NA -0.37 -5.86 -0.31 1.12e-8 Longevity;Endometriosis; CRC cis rs17711722 0.565 rs4275112 chr7:65198619 T/G cg00343986 chr7:65444356 GUSB -0.46 -6.71 -0.35 8.45e-11 Calcium levels; CRC cis rs1109861 0.525 rs606139 chr10:11205719 A/G cg24910943 chr10:11206320 CUGBP2 0.28 8.08 0.41 1.22e-14 Urinary albumin-to-creatinine ratio; CRC cis rs561341 0.714 rs55925849 chr17:30253085 C/T cg19193384 chr17:30244184 NA -0.63 -7.17 -0.37 4.91e-12 Hip circumference adjusted for BMI; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg14114033 chr7:105752648 SYPL1 0.4 6.32 0.33 8.48e-10 Liver disease severity in Alagille syndrome; CRC cis rs2011503 0.941 rs2074302 chr19:19381728 G/C cg11584989 chr19:19387371 SF4 0.53 6.44 0.33 4.19e-10 Bipolar disorder; CRC trans rs596169 0.655 rs6697647 chr1:219159834 A/G cg00778190 chr1:95068029 NA 0.74 6.38 0.33 5.97e-10 Intraocular pressure; CRC cis rs10504229 0.565 rs7010503 chr8:58147127 G/A cg05313129 chr8:58192883 C8orf71 -0.39 -5.88 -0.31 9.84e-9 Developmental language disorder (linguistic errors); CRC cis rs1728785 1.000 rs1728773 chr16:68563644 A/C cg02972257 chr16:68554789 NA -0.58 -7.08 -0.36 9.03e-12 Ulcerative colitis; CRC cis rs478304 0.651 rs11227281 chr11:65496558 T/C cg27068330 chr11:65405492 SIPA1 -0.63 -9.75 -0.47 6.92e-20 Acne (severe); CRC cis rs7309 0.870 rs2358016 chr2:162007430 C/G cg16506815 chr2:162101123 NA -0.48 -7.93 -0.4 3.39e-14 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Educational attainment; CRC cis rs9926296 0.712 rs2434872 chr16:89716915 C/G cg01097406 chr16:89675127 NA 0.53 9.64 0.47 1.53e-19 Vitiligo; CRC cis rs1577917 0.761 rs117452258 chr6:86554211 G/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.51 -6.81 -0.35 4.6e-11 Response to antipsychotic treatment; CRC cis rs561341 0.941 rs72825746 chr17:30364610 G/A cg12193833 chr17:30244370 NA -0.74 -8.65 -0.43 2.34e-16 Hip circumference adjusted for BMI; CRC cis rs801193 1.000 rs2659912 chr7:66157999 G/C cg25985355 chr7:65971099 NA -0.32 -5.62 -0.3 3.97e-8 Aortic root size; CRC cis rs6502050 0.799 rs4789681 chr17:80100546 G/A cg19223190 chr17:80058835 NA 0.4 6.36 0.33 6.88e-10 Life satisfaction; CRC cis rs10504229 0.815 rs17805008 chr8:58160185 G/T cg20607798 chr8:58055168 NA 0.46 5.69 0.3 2.8e-8 Developmental language disorder (linguistic errors); CRC cis rs2075371 1.000 rs7486 chr7:133975183 A/G cg20476274 chr7:133979776 SLC35B4 0.81 14.88 0.63 1.23e-38 Mean platelet volume; CRC cis rs2795502 1.000 rs3121278 chr10:43375646 G/T cg27426351 chr10:43362370 NA 0.47 5.87 0.31 1.08e-8 Blood protein levels; CRC trans rs941408 0.515 rs2110118 chr19:2775144 T/C cg19676328 chr12:49525230 TUBA1B -0.45 -5.98 -0.31 5.71e-9 Total cholesterol levels; CRC cis rs7312933 0.645 rs11181404 chr12:42683840 T/C cg19980929 chr12:42632907 YAF2 0.44 6.48 0.34 3.28e-10 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CRC cis rs10849893 0.576 rs7134248 chr12:121897052 T/C cg01154721 chr12:121881891 KDM2B -0.43 -6.23 -0.32 1.41e-9 Fasting blood glucose;Fasting blood glucose (BMI interaction); CRC cis rs6502050 0.604 rs9897355 chr17:80078095 G/A cg22110888 chr17:80059540 CCDC57 -0.41 -6.44 -0.33 4.12e-10 Life satisfaction; CRC cis rs13118159 0.550 rs28522910 chr4:1374774 C/T cg20887711 chr4:1340912 KIAA1530 0.67 9.61 0.47 1.95e-19 Longevity; CRC cis rs703842 0.963 rs2069506 chr12:58142854 C/A cg00677455 chr12:58241039 CTDSP2 0.66 8.71 0.43 1.56e-16 Multiple sclerosis; CRC cis rs6951245 1.000 rs11770909 chr7:1086716 G/A cg21664854 chr7:1097933 C7orf50;GPR146 0.79 8.73 0.43 1.27e-16 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs728616 1.000 rs12414891 chr10:81690385 G/C cg11900509 chr10:81946545 ANXA11 -0.65 -6.71 -0.35 8.77e-11 Chronic obstructive pulmonary disease-related biomarkers; CRC trans rs10504390 0.656 rs78912269 chr8:66511446 C/T cg26403416 chr21:43771339 TFF2 0.64 6.54 0.34 2.37e-10 IgG glycosylation; CRC cis rs2404602 0.692 rs35077207 chr15:76935306 A/G cg23625390 chr15:77176239 SCAPER 0.48 6.92 0.36 2.34e-11 Blood metabolite levels; CRC cis rs9660992 0.736 rs1180734 chr1:205255438 A/G cg21643547 chr1:205240462 TMCC2 -0.44 -7.6 -0.39 3.03e-13 Mean corpuscular volume;Mean platelet volume; CRC cis rs6714710 0.627 rs6748124 chr2:98519014 T/C cg26665480 chr2:98280029 ACTR1B 0.53 7.41 0.38 1.08e-12 Posterior cortical atrophy and Alzheimer's disease; CRC cis rs2842992 0.662 rs2273825 chr6:160211424 A/C cg19482086 chr6:160211437 TCP1;MRPL18 0.84 13.56 0.6 1.38e-33 Age-related macular degeneration (geographic atrophy); CRC cis rs4665809 0.590 rs4665319 chr2:26424583 A/C cg26119090 chr2:26468346 HADHA;HADHB -0.82 -11.25 -0.53 4.62e-25 Gut microbiome composition (summer); CRC cis rs17711722 0.701 rs781143 chr7:65439879 G/C cg00343986 chr7:65444356 GUSB 0.57 8.59 0.43 3.61e-16 Calcium levels; CRC cis rs9649213 0.593 rs12728 chr7:97922851 C/T cg21770322 chr7:97807741 LMTK2 0.56 9.37 0.46 1.2e-18 Prostate cancer (SNP x SNP interaction); CRC trans rs4698169 0.510 rs675984 chr4:17123821 A/G cg12890291 chr7:22234163 RAPGEF5 -0.78 -7.0 -0.36 1.48e-11 Temperament (bipolar disorder); CRC cis rs2976388 0.609 rs2572907 chr8:143801938 G/A cg12516270 chr8:143859308 LYNX1 0.4 7.1 0.36 7.66e-12 Urinary tract infection frequency; CRC cis rs3749237 1.000 rs11130216 chr3:49736172 C/A cg05072774 chr3:49840536 C3orf54 -0.43 -5.71 -0.3 2.58e-8 Resting heart rate; CRC cis rs941873 0.868 rs2233718 chr10:81108956 A/G cg09469691 chr10:81107165 PPIF 0.5 7.91 0.4 3.85e-14 Height; CRC cis rs1799949 1.000 rs9646412 chr17:41425893 A/T cg25072359 chr17:41440525 NA 0.43 6.35 0.33 6.97e-10 Menopause (age at onset); CRC cis rs1552244 1.000 rs13319597 chr3:10126312 A/C cg00166722 chr3:10149974 C3orf24 -0.7 -9.7 -0.47 9.73e-20 Alzheimer's disease; CRC cis rs1572438 1.000 rs873560 chr6:875559 A/G cg13447295 chr6:887704 NA -0.45 -6.42 -0.33 4.7e-10 Aging; CRC cis rs7586879 0.828 rs10184813 chr2:25090236 T/C cg04586622 chr2:25135609 ADCY3 -0.56 -9.4 -0.46 9.79e-19 Body mass index; CRC cis rs1552172 0.853 rs10752826 chr1:145602791 C/G cg25221984 chr1:145714143 CD160 0.35 5.65 0.3 3.39e-8 Breast cancer; CRC cis rs9302065 0.681 rs9524902 chr13:95963518 C/T cg26751094 chr13:95954534 ABCC4 -0.34 -5.99 -0.31 5.51e-9 Blood metabolite levels; CRC trans rs2303319 0.504 rs62189054 chr2:162624654 C/G cg11326919 chr17:43324904 LOC100133991 -0.64 -5.99 -0.31 5.65e-9 Cognitive function; CRC cis rs7119 0.717 rs12910512 chr15:77817253 C/A cg27398640 chr15:77910606 LINGO1 -0.45 -7.95 -0.4 2.94e-14 Type 2 diabetes; CRC cis rs6674970 0.966 rs4512652 chr1:151115690 G/C cg11822372 chr1:151115635 SEMA6C 0.5 7.25 0.37 2.91e-12 Childhood ear infection; CRC cis rs644799 0.965 rs565771 chr11:95644179 T/A cg25622487 chr11:95524042 FAM76B;CEP57 0.73 11.13 0.52 1.19e-24 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC trans rs1005277 0.505 rs200937 chr10:38135772 T/C cg23533926 chr12:111358616 MYL2 -0.44 -6.54 -0.34 2.35e-10 Extrinsic epigenetic age acceleration; CRC cis rs11025559 0.631 rs11025571 chr11:20482801 C/G cg19653624 chr11:20408972 PRMT3 0.59 6.34 0.33 7.43e-10 Pursuit maintenance gain; CRC cis rs7584330 0.554 rs9646716 chr2:238443784 C/T cg14458575 chr2:238380390 NA 0.53 7.38 0.38 1.29e-12 Prostate cancer; CRC cis rs72781680 0.679 rs718138 chr2:23976324 G/A cg08917208 chr2:24149416 ATAD2B 0.56 6.45 0.34 3.89e-10 Lymphocyte counts; CRC cis rs4819052 0.851 rs4819044 chr21:46660118 G/A cg19498844 chr21:46707878 POFUT2;LOC642852 0.75 10.82 0.51 1.49e-23 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs1215050 0.791 rs984940 chr4:98811756 T/A cg05340658 chr4:99064831 C4orf37 0.47 6.83 0.35 4.02e-11 Waist-to-hip ratio adjusted for body mass index; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg10534439 chr2:69969029 ANXA4 0.4 6.94 0.36 2.04e-11 Liver disease severity in Alagille syndrome; CRC cis rs17592366 0.517 rs4982222 chr14:35301997 T/C cg09327582 chr14:35236912 BAZ1A 0.48 6.85 0.35 3.69e-11 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells; CRC cis rs7959452 0.590 rs11177644 chr12:69785748 A/G cg14784868 chr12:69753453 YEATS4 0.8 13.3 0.59 1.3e-32 Blood protein levels; CRC cis rs12887734 0.524 rs17791722 chr14:104286210 C/T cg01849466 chr14:104193079 ZFYVE21 -0.43 -6.87 -0.35 3.17e-11 Schizophrenia;Autism spectrum disorder or schizophrenia; CRC trans rs35110281 0.744 rs162373 chr21:44927107 C/A cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO -0.38 -5.97 -0.31 6.2e-9 Mean corpuscular volume; CRC cis rs736408 0.716 rs2300149 chr3:52822921 C/T cg18404041 chr3:52824283 ITIH1 -0.5 -10.35 -0.5 6.66e-22 Bipolar disorder; CRC cis rs868943 0.743 rs1890425 chr6:116339295 T/C cg18764771 chr6:116381957 FRK 0.26 6.35 0.33 7.26e-10 Total cholesterol levels; CRC cis rs1568889 0.838 rs11030187 chr11:28044391 A/C cg06544937 chr11:28130018 METT5D1;KIF18A 0.94 16.01 0.66 4.76e-43 Bipolar disorder; CRC cis rs34375054 0.573 rs12581813 chr12:125656402 A/G cg25124228 chr12:125621409 AACS -0.57 -6.41 -0.33 4.98e-10 Post bronchodilator FEV1/FVC ratio; CRC cis rs6484504 0.512 rs2774402 chr11:31312897 G/C cg14844989 chr11:31128820 NA 0.35 6.36 0.33 6.64e-10 Red blood cell count; CRC cis rs4689388 0.926 rs11732178 chr4:6292643 G/C cg00701064 chr4:6280414 WFS1 0.75 13.29 0.59 1.43e-32 Type 2 diabetes and other traits;Type 2 diabetes; CRC cis rs7586879 0.828 rs10184813 chr2:25090236 T/C cg22495460 chr2:25135724 ADCY3 -0.84 -14.02 -0.61 2.41e-35 Body mass index; CRC cis rs950169 0.887 rs12903946 chr15:84954430 T/C cg17507749 chr15:85114479 UBE2QP1 0.74 10.59 0.5 9.91e-23 Schizophrenia; CRC cis rs644799 0.965 rs534488 chr11:95562327 G/A cg25478527 chr11:95522999 CEP57;FAM76B 0.52 7.86 0.4 5.6e-14 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg09329705 chr19:4909474 UHRF1 0.42 6.11 0.32 2.74e-9 Response to antipsychotic treatment; CRC cis rs4653767 1.000 rs10916030 chr1:226919908 C/T cg05049329 chr1:226924846 ITPKB 0.4 8.86 0.44 5.05e-17 Parkinson's disease; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg14229688 chr14:77564380 KIAA1737 0.46 6.3 0.33 9.47e-10 Anxiety disorder; CRC cis rs13108904 0.557 rs1680030 chr4:1245500 A/T cg23123621 chr4:1343375 KIAA1530 -0.36 -5.84 -0.31 1.29e-8 Obesity-related traits; CRC cis rs7659604 1.000 rs35224452 chr4:122664677 C/T cg20573242 chr4:122745356 CCNA2 0.41 6.14 0.32 2.36e-9 Type 2 diabetes; CRC cis rs9914988 0.943 rs7211502 chr17:27163295 C/A cg12682573 chr17:27188876 MIR451;MIR144 0.56 7.48 0.38 6.64e-13 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs4853012 0.838 rs4429500 chr2:74345336 A/G cg01017244 chr2:74357527 NA 0.64 8.98 0.44 2.13e-17 Gestational age at birth (maternal effect); CRC trans rs7647973 0.626 rs12715437 chr3:49751856 T/C cg21659725 chr3:3221576 CRBN -0.63 -7.03 -0.36 1.21e-11 Menarche (age at onset); CRC cis rs6496044 0.568 rs2880764 chr15:86056408 A/G cg17133734 chr15:86042851 AKAP13 0.42 7.02 0.36 1.28e-11 Interstitial lung disease; CRC cis rs7208859 0.673 rs9899943 chr17:29223925 G/A cg14008862 chr17:28927542 LRRC37B2 0.55 5.75 0.3 2.04e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs1865760 0.865 rs10946800 chr6:25957773 C/T cg17691542 chr6:26056736 HIST1H1C 0.55 8.41 0.42 1.25e-15 Height; CRC cis rs875971 0.830 rs4718358 chr7:65973668 T/C cg00343986 chr7:65444356 GUSB 0.43 6.29 0.33 9.88e-10 Aortic root size; CRC cis rs4880487 0.888 rs67699390 chr10:1252427 G/A cg03183215 chr10:1252341 ADARB2 -0.3 -6.37 -0.33 6.38e-10 Migraine; CRC cis rs2576037 0.526 rs998819 chr18:44564181 C/T cg24750912 chr18:44543259 TCEB3CL;KATNAL2 -0.32 -6.35 -0.33 7.09e-10 Personality dimensions; CRC cis rs875971 1.000 rs6460296 chr7:65895139 C/T cg00343986 chr7:65444356 GUSB 0.43 6.29 0.33 1.03e-9 Aortic root size; CRC cis rs4689388 0.889 rs10026334 chr4:6294607 G/A cg25554036 chr4:6271136 WFS1 0.53 8.7 0.43 1.59e-16 Type 2 diabetes and other traits;Type 2 diabetes; CRC cis rs7208859 0.623 rs11657391 chr17:29194287 G/A cg13385521 chr17:29058706 SUZ12P 0.69 8.01 0.4 2.02e-14 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs7617773 0.780 rs4392440 chr3:48343920 C/T cg11946769 chr3:48343235 NME6 0.72 9.63 0.47 1.74e-19 Coronary artery disease; CRC cis rs3096299 0.658 rs34590044 chr16:89543157 A/C cg01788221 chr16:89496183 ANKRD11 -0.4 -6.08 -0.32 3.37e-9 Multiple myeloma (IgH translocation); CRC cis rs4664308 0.967 rs17241792 chr2:160915205 C/T cg03641300 chr2:160917029 PLA2R1 -0.77 -13.06 -0.58 1.11e-31 Idiopathic membranous nephropathy; CRC cis rs7666738 0.830 rs11932887 chr4:99072965 C/G cg17366294 chr4:99064904 C4orf37 0.42 7.01 0.36 1.34e-11 Colonoscopy-negative controls vs population controls; CRC cis rs10089 1.000 rs3805612 chr5:127505316 G/A cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.7 9.53 0.46 3.72e-19 Ileal carcinoids; CRC cis rs12474201 0.832 rs11695058 chr2:46978349 A/G cg06386533 chr2:46925753 SOCS5 0.75 12.23 0.56 1.36e-28 Height; CRC cis rs8180040 0.966 rs56351005 chr3:47430186 G/T cg27129171 chr3:47204927 SETD2 -0.6 -9.37 -0.46 1.19e-18 Colorectal cancer; CRC cis rs2032447 0.507 rs199741 chr6:25931577 A/G cg03517284 chr6:25882590 NA -0.84 -11.79 -0.55 5.24e-27 Intelligence (multi-trait analysis); CRC cis rs2032447 0.899 rs1090947 chr6:26076642 T/C cg12310025 chr6:25882481 NA -0.48 -6.71 -0.35 8.47e-11 Intelligence (multi-trait analysis); CRC cis rs10256972 0.552 rs2960830 chr7:1200641 T/C cg23708337 chr7:1209742 NA 0.51 7.81 0.4 7.79e-14 Longevity;Endometriosis; CRC cis rs875971 0.895 rs7788984 chr7:65915616 A/G cg18876405 chr7:65276391 NA 0.51 8.56 0.43 4.47e-16 Aortic root size; CRC cis rs79057730 0.528 rs6965219 chr7:821807 C/G cg05729249 chr7:766119 PRKAR1B;HEATR2 0.57 6.3 0.33 9.68e-10 Initial pursuit acceleration; CRC cis rs2730245 0.550 rs2709860 chr7:158651156 A/T cg23730037 chr7:158596552 ESYT2 -0.43 -6.42 -0.33 4.83e-10 Height; CRC cis rs9513627 0.833 rs4605005 chr13:100132471 T/C cg15490075 chr13:100150979 NA 0.58 5.83 0.31 1.36e-8 Obesity-related traits; CRC cis rs6543140 0.890 rs61122764 chr2:102999520 A/G cg09003973 chr2:102972529 NA 0.41 5.65 0.3 3.47e-8 Blood protein levels; CRC cis rs7772486 0.720 rs9403757 chr6:146261271 C/T cg13319975 chr6:146136371 FBXO30 0.41 6.24 0.33 1.32e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs6499255 1.000 rs6499253 chr16:69802672 C/T cg00738113 chr16:70207722 CLEC18C -0.42 -6.06 -0.32 3.64e-9 IgE levels; CRC cis rs116095464 0.558 rs9312977 chr5:221916 G/C cg22496380 chr5:211416 CCDC127 -0.83 -9.55 -0.47 3.03e-19 Breast cancer; CRC cis rs2228479 0.702 rs62053701 chr16:89860584 G/A cg19635926 chr16:89946313 TCF25 0.67 6.25 0.33 1.25e-9 Skin colour saturation; CRC cis rs2120019 0.938 rs8033925 chr15:75311959 A/G cg17294928 chr15:75287854 SCAMP5 -0.76 -11.11 -0.52 1.4e-24 Blood trace element (Zn levels); CRC cis rs919433 1.000 rs6761919 chr2:198163328 A/G cg03934865 chr2:198174659 NA -0.45 -8.07 -0.41 1.33e-14 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC cis rs2549003 0.966 rs10072571 chr5:131816711 A/C cg02551604 chr5:131831745 NA -0.54 -8.36 -0.42 1.76e-15 Asthma (sex interaction); CRC cis rs28386778 0.765 rs2070680 chr17:61986988 A/G cg25654072 chr17:61904446 PSMC5;FTSJ3 -0.57 -8.78 -0.44 9.09e-17 Prudent dietary pattern; CRC cis rs9372498 0.536 rs62421539 chr6:118730559 C/A cg07617317 chr6:118971624 C6orf204 0.52 6.52 0.34 2.68e-10 Diastolic blood pressure; CRC cis rs875971 1.000 rs3735148 chr7:65971009 T/G cg18876405 chr7:65276391 NA 0.51 8.78 0.44 9.39e-17 Aortic root size; CRC cis rs2179367 0.959 rs9285519 chr6:149692935 G/A cg16235748 chr6:149772707 ZC3H12D -0.34 -5.66 -0.3 3.22e-8 Dupuytren's disease; CRC cis rs2976388 0.507 rs2572874 chr8:143837219 C/T cg15511327 chr8:143859410 LYNX1 0.5 8.8 0.44 7.87e-17 Urinary tract infection frequency; CRC cis rs2179367 0.959 rs4895789 chr6:149764654 T/C cg07828024 chr6:149772892 ZC3H12D -0.39 -6.62 -0.34 1.44e-10 Dupuytren's disease; CRC cis rs7259376 0.729 rs3867187 chr19:22570220 C/G cg02657401 chr19:22469223 NA -0.3 -6.44 -0.33 4.12e-10 Menopause (age at onset); CRC cis rs8170 1.000 rs56028644 chr19:17388790 C/T cg04749549 chr19:17459798 NA -0.45 -6.11 -0.32 2.76e-9 Breast cancer (estrogen-receptor negative);Breast Cancer in BRCA1 mutation carriers;Ovarian cancer;Breast cancer;Epithelial ovarian cancer; CRC cis rs9549367 0.713 rs1755690 chr13:113824266 T/C cg18105134 chr13:113819100 PROZ 0.83 13.04 0.58 1.25e-31 Platelet distribution width; CRC cis rs1555895 0.576 rs7080989 chr10:851455 C/G cg10556349 chr10:835070 NA -0.37 -7.37 -0.38 1.39e-12 Survival in rectal cancer; CRC cis rs9462846 0.853 rs2395940 chr6:42860467 C/G cg10862848 chr6:42927986 GNMT -0.27 -5.7 -0.3 2.71e-8 Blood protein levels; CRC cis rs11098499 0.863 rs17050695 chr4:120489527 G/T cg09307838 chr4:120376055 NA 0.64 9.65 0.47 1.42e-19 Corneal astigmatism; CRC cis rs1728785 1.000 rs11647432 chr16:68565426 C/T cg02972257 chr16:68554789 NA -0.58 -7.08 -0.36 9.03e-12 Ulcerative colitis; CRC cis rs7772486 0.754 rs2328709 chr6:146106819 A/G cg13319975 chr6:146136371 FBXO30 0.47 6.98 0.36 1.67e-11 Lobe attachment (rater-scored or self-reported); CRC cis rs780096 0.587 rs1049817 chr2:27550967 A/G cg27432699 chr2:27873401 GPN1 -0.49 -7.47 -0.38 7.14e-13 Total body bone mineral density; CRC cis rs11168351 0.833 rs6580652 chr12:48447105 C/A cg15465823 chr12:48382534 COL2A1 -0.38 -6.34 -0.33 7.42e-10 Bipolar disorder and schizophrenia; CRC cis rs9611565 0.592 rs5751101 chr22:41828111 C/T cg03806693 chr22:41940476 POLR3H 1.1 13.32 0.59 1.09e-32 Vitiligo; CRC cis rs6912958 1.000 rs13214153 chr6:88153983 G/C cg12350822 chr6:88032061 C6orf162;GJB7 -0.35 -6.69 -0.35 9.58e-11 Monocyte percentage of white cells; CRC cis rs7944584 0.552 rs12361415 chr11:47474146 T/G cg20307385 chr11:47447363 PSMC3 0.83 11.79 0.55 5.16e-27 Fasting blood glucose;Fasting blood glucose (BMI interaction); CRC cis rs9649213 0.533 rs62478235 chr7:98030349 G/C cg09267113 chr7:98030324 BAIAP2L1 -0.94 -11.97 -0.55 1.23e-27 Prostate cancer (SNP x SNP interaction); CRC cis rs847577 0.540 rs3847055 chr7:97680645 A/G cg24562669 chr7:97807699 LMTK2 -0.5 -7.39 -0.38 1.23e-12 Breast cancer; CRC cis rs763014 1.000 rs7205409 chr16:642610 A/G cg00802000 chr16:706648 WDR90 -0.43 -6.34 -0.33 7.74e-10 Height; CRC cis rs9522267 0.535 rs11069898 chr13:112231512 C/T cg26182253 chr13:112236782 NA 0.31 6.27 0.33 1.12e-9 Hepatitis; CRC cis rs2257205 0.667 rs7214805 chr17:56931895 C/G cg25885038 chr17:56607967 SEPT4 -0.53 -5.82 -0.31 1.43e-8 Pancreatic cancer; CRC cis rs3785574 0.962 rs7215915 chr17:61828385 C/T cg23090583 chr17:61904693 PSMC5;FTSJ3 0.64 9.43 0.46 7.63e-19 Height; CRC cis rs11628318 0.614 rs942022 chr14:103108842 C/T cg02094049 chr14:103021097 NA -0.48 -5.61 -0.3 4.31e-8 Platelet count; CRC cis rs7666738 0.830 rs34916200 chr4:98851593 C/T cg05340658 chr4:99064831 C4orf37 0.56 8.33 0.42 2.21e-15 Colonoscopy-negative controls vs population controls; CRC cis rs8180040 0.966 rs878659 chr3:47500662 G/A cg10298567 chr3:47292165 KIF9 -0.35 -5.85 -0.31 1.17e-8 Colorectal cancer; CRC cis rs713477 0.618 rs6573033 chr14:55919060 C/G cg21836586 chr14:55907198 TBPL2 0.33 5.89 0.31 9.67e-9 Pediatric bone mineral content (femoral neck); CRC trans rs877282 0.853 rs11595510 chr10:756757 C/G cg22713356 chr15:30763199 NA 1.17 13.98 0.61 3.58e-35 Uric acid levels; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg13735691 chr19:36103707 HAUS5 0.44 6.09 0.32 3.12e-9 Anxiety disorder; CRC cis rs72781680 0.611 rs72797818 chr2:24351107 G/A cg06627628 chr2:24431161 ITSN2 -0.54 -6.3 -0.33 9.34e-10 Lymphocyte counts; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg09974566 chr22:32150118 DEPDC5 0.43 6.22 0.32 1.51e-9 Intelligence (multi-trait analysis); CRC cis rs561341 0.883 rs72821942 chr17:30234460 C/T cg19193384 chr17:30244184 NA -0.59 -7.22 -0.37 3.57e-12 Hip circumference adjusted for BMI; CRC trans rs925098 0.577 rs2724470 chr4:17996046 A/G cg09997638 chr19:17530742 FAM125A -0.4 -5.96 -0.31 6.54e-9 Birth weight;Height; CRC cis rs9291683 0.609 rs36084205 chr4:10028678 A/C cg11266682 chr4:10021025 SLC2A9 0.54 11.4 0.53 1.36e-25 Bone mineral density; CRC cis rs3858526 0.883 rs10769320 chr11:5932831 G/C cg13902645 chr11:5959945 NA -0.6 -8.22 -0.41 4.88e-15 DNA methylation (variation); CRC cis rs2882667 0.898 rs10058347 chr5:138361358 G/A cg09476006 chr5:138032270 NA 0.44 7.36 0.38 1.52e-12 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs514406 0.755 rs11206015 chr1:53242187 T/C cg24675658 chr1:53192096 ZYG11B 0.6 9.42 0.46 8.35e-19 Monocyte count; CRC cis rs6772849 0.796 rs9841521 chr3:128392274 A/G cg08795948 chr3:128337044 NA 0.36 6.15 0.32 2.24e-9 Monocyte percentage of white cells;Monocyte count; CRC cis rs17023223 0.537 rs12097967 chr1:119702913 A/G cg05756136 chr1:119680316 WARS2 -0.52 -7.13 -0.37 6.28e-12 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for BMI in active individuals; CRC cis rs1223397 0.589 rs364493 chr6:13297020 C/T cg06879394 chr6:13274151 PHACTR1 -0.41 -5.88 -0.31 1.01e-8 Blood pressure; CRC cis rs6565180 1.000 rs12930787 chr16:30381303 C/G cg01392867 chr16:30410429 ZNF48 -0.39 -6.21 -0.32 1.58e-9 Tonsillectomy; CRC trans rs6544773 0.668 rs341597 chr2:45066963 A/G cg10208897 chr5:178548229 ADAMTS2 0.35 6.11 0.32 2.84e-9 Mosquito bite size; CRC cis rs28386778 0.797 rs4968664 chr17:61851366 C/G cg11494091 chr17:61959527 GH2 0.59 10.1 0.49 4.39e-21 Prudent dietary pattern; CRC cis rs929354 0.772 rs6459738 chr7:156998532 T/G cg17757837 chr7:157058334 UBE3C 0.74 12.6 0.57 5.83e-30 Body mass index; CRC cis rs9296092 0.560 rs17627049 chr6:33537802 G/T cg13560919 chr6:33536144 NA -0.44 -6.06 -0.32 3.68e-9 Age at smoking initiation in chronic obstructive pulmonary disease; CRC cis rs7666738 0.800 rs2839836 chr4:98970512 A/G cg05340658 chr4:99064831 C4orf37 0.6 9.34 0.46 1.48e-18 Colonoscopy-negative controls vs population controls; CRC cis rs2836974 0.899 rs2836938 chr21:40574191 C/T cg06238570 chr21:40685208 BRWD1 0.78 10.7 0.51 3.88e-23 Cognitive function; CRC cis rs362272 0.505 rs10155132 chr4:3369500 A/G cg16416165 chr4:3325029 RGS12 0.39 5.95 0.31 6.97e-9 Serum sulfate level; CRC cis rs4555082 0.957 rs2816622 chr14:105733114 T/C cg13114125 chr14:105738426 BRF1 -0.75 -11.26 -0.53 4.13e-25 Mean platelet volume;Platelet distribution width; CRC cis rs2832191 0.791 rs2832198 chr21:30498240 C/T cg08807101 chr21:30365312 RNF160 0.61 9.48 0.46 5.06e-19 Dental caries; CRC cis rs6963495 0.510 rs56353563 chr7:105226698 G/C cg02135003 chr7:105160482 PUS7 -0.71 -7.68 -0.39 1.88e-13 Bipolar disorder (body mass index interaction); CRC cis rs4727027 0.933 rs1058059 chr7:148879134 A/T cg23583168 chr7:148888333 NA -0.93 -16.53 -0.67 4.09e-45 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC cis rs6502050 0.799 rs6416859 chr17:80111442 G/C cg02741985 chr17:80059408 CCDC57 0.43 7.15 0.37 5.66e-12 Life satisfaction; CRC cis rs741668 0.931 rs61953330 chr13:46588876 T/A cg06018095 chr13:46550134 ZC3H13 0.41 5.73 0.3 2.21e-8 Cerebrospinal fluid clusterin levels; CRC cis rs2386661 0.956 rs10905489 chr10:5670541 G/C cg26603656 chr10:5671107 NA -0.48 -7.94 -0.4 3.14e-14 Breast cancer; CRC trans rs1945213 0.659 rs11227133 chr11:55836620 T/C cg03929089 chr4:120376271 NA 0.56 6.35 0.33 7.04e-10 Acute lymphoblastic leukemia (childhood); CRC cis rs9914988 0.943 rs59461345 chr17:27151852 G/T cg12682573 chr17:27188876 MIR451;MIR144 0.57 7.99 0.4 2.37e-14 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs9649213 0.593 rs6948540 chr7:97960066 A/G cg24562669 chr7:97807699 LMTK2 0.42 7.02 0.36 1.3e-11 Prostate cancer (SNP x SNP interaction); CRC cis rs8067545 0.750 rs4005937 chr17:19959828 A/C cg13482628 chr17:19912719 NA 0.47 7.45 0.38 8.47e-13 Schizophrenia; CRC cis rs9309711 0.643 rs4535074 chr2:3481637 A/G cg15541040 chr2:3486749 NA -0.52 -8.32 -0.42 2.29e-15 Neurofibrillary tangles; CRC trans rs11722228 0.522 rs7662229 chr4:10133014 A/T cg26043149 chr18:55253948 FECH 1.14 19.64 0.73 2.22e-57 Gout;Urate levels;Serum uric acid levels; CRC trans rs7726839 0.540 rs12517638 chr5:645484 C/T cg25482853 chr8:67687455 SGK3 1.13 13.26 0.59 1.97e-32 Obesity-related traits; CRC trans rs9354352 1.000 rs9354352 chr6:66696272 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.59 8.6 0.43 3.21e-16 Initial pursuit acceleration in psychotic disorders; CRC cis rs6088580 0.634 rs6087588 chr20:33066369 T/C cg08999081 chr20:33150536 PIGU 0.61 11.3 0.53 3.08e-25 Glomerular filtration rate (creatinine); CRC cis rs9322193 0.923 rs1413654 chr6:150105092 G/A cg05861140 chr6:150128134 PCMT1 -0.43 -7.05 -0.36 1.03e-11 Lung cancer; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg01743962 chr17:17686332 RAI1 0.41 5.97 0.31 6.1e-9 Response to antipsychotic treatment; CRC cis rs826838 1.000 rs7315028 chr12:38710523 G/A cg13010199 chr12:38710504 ALG10B 0.48 6.36 0.33 6.71e-10 Heart rate; CRC cis rs4242434 0.819 rs1059592 chr8:22477778 G/A cg03733263 chr8:22462867 KIAA1967 0.94 16.8 0.68 3.46e-46 Exploratory eye movement dysfunction in schizophrenia (cognitive search score); CRC cis rs4819052 0.851 rs2838826 chr21:46655785 A/G cg11663144 chr21:46675770 NA -0.76 -11.91 -0.55 2e-27 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC trans rs7395662 0.895 rs2221553 chr11:48688784 C/T cg21153622 chr11:89784906 NA -0.48 -7.72 -0.39 1.45e-13 HDL cholesterol; CRC cis rs4728302 0.838 rs6974143 chr7:133603550 G/A cg10665199 chr7:133106180 EXOC4 0.38 5.67 0.3 3.13e-8 Intelligence;Intelligence (multi-trait analysis); CRC cis rs12422267 0.536 rs58521339 chr12:132609486 T/C cg09764611 chr12:132620959 NA -0.64 -8.48 -0.42 7.72e-16 Plasma amyloid beta peptide concentrations (ABx-40); CRC trans rs7267979 0.966 rs2482923 chr20:25308981 T/C cg17903999 chr18:56338584 MALT1 0.43 6.85 0.35 3.73e-11 Liver enzyme levels (alkaline phosphatase); CRC cis rs4819052 0.885 rs9980676 chr21:46665430 A/G cg19498844 chr21:46707878 POFUT2;LOC642852 0.77 11.12 0.52 1.33e-24 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC trans rs9826463 0.757 rs73238200 chr3:142204634 C/T cg13928417 chr9:124498782 DAB2IP -0.53 -6.04 -0.32 4.07e-9 QRS duration in Tripanosoma cruzi seropositivity; CRC cis rs898097 0.737 rs3785521 chr17:80895769 A/G cg16060761 chr17:80687452 NA -0.44 -6.23 -0.32 1.43e-9 Breast cancer; CRC cis rs10782582 0.593 rs4638068 chr1:76161663 G/A cg10523679 chr1:76189770 ACADM -0.41 -5.81 -0.3 1.49e-8 Daytime sleep phenotypes; CRC cis rs12497850 0.931 rs7430198 chr3:48988760 T/C cg07636037 chr3:49044803 WDR6 1.02 18.3 0.71 4.38e-52 Parkinson's disease; CRC trans rs875971 0.660 rs2191268 chr7:66110224 C/T cg26358659 chr3:60740074 FHIT -0.37 -6.06 -0.32 3.68e-9 Aortic root size; CRC cis rs877282 0.891 rs11595385 chr10:800539 A/G cg06581033 chr10:766294 NA -0.51 -5.66 -0.3 3.34e-8 Uric acid levels; CRC cis rs2228479 0.764 rs35518096 chr16:89961140 C/A cg04013166 chr16:89971882 TCF25 0.59 6.52 0.34 2.68e-10 Skin colour saturation; CRC trans rs3733585 0.673 rs7377578 chr4:9952775 T/C cg26043149 chr18:55253948 FECH -0.5 -7.71 -0.39 1.51e-13 Cleft plate (environmental tobacco smoke interaction); CRC cis rs6684514 1.000 rs2273832 chr1:156233143 A/G cg16558208 chr1:156270281 VHLL 0.62 9.74 0.47 7.36e-20 Mean corpuscular hemoglobin concentration;Glycated hemoglobin levels; CRC cis rs4563143 0.675 rs73025085 chr19:29247018 C/A cg12756686 chr19:29218302 NA 0.6 8.99 0.44 2.04e-17 Methadone dose in opioid dependence; CRC cis rs28493229 0.881 rs10404911 chr19:41174903 A/T cg21869046 chr19:41225005 ITPKC 0.4 6.03 0.32 4.47e-9 Kawasaki disease; CRC cis rs7618915 0.547 rs6976 chr3:52728804 C/T cg07507251 chr3:52567010 NT5DC2 0.48 6.84 0.35 3.88e-11 Bipolar disorder; CRC cis rs2979489 0.945 rs34960391 chr8:30332723 G/A cg26383811 chr8:30366931 RBPMS -0.7 -9.77 -0.47 5.95e-20 Mean corpuscular hemoglobin;Plateletcrit;Neutrophil count;Granulocyte count;Sum basophil neutrophil counts;Mean corpuscular volume;Myeloid white cell count;Sum neutrophil eosinophil counts; CRC cis rs6062302 0.522 rs2297427 chr20:62221364 G/A cg06363034 chr20:62225388 GMEB2 -0.45 -6.95 -0.36 1.94e-11 Glioblastoma; CRC cis rs10927875 0.662 rs848309 chr1:16308447 T/C cg24140574 chr1:16342155 HSPB7 0.41 5.93 0.31 7.49e-9 Dilated cardiomyopathy; CRC cis rs11098499 0.754 rs10212775 chr4:120239244 G/C cg09307838 chr4:120376055 NA 0.62 9.75 0.47 6.92e-20 Corneal astigmatism; CRC cis rs6951245 0.872 rs113119264 chr7:1080564 G/A cg08132940 chr7:1081526 C7orf50 -0.54 -5.64 -0.3 3.65e-8 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC trans rs12478296 0.685 rs12473450 chr2:242991746 C/T cg18288967 chr1:45987694 PRDX1 0.64 7.86 0.4 5.4e-14 Obesity-related traits; CRC cis rs11958404 0.860 rs7730844 chr5:157461208 C/T cg05962755 chr5:157440814 NA 1.0 12.82 0.58 8.84e-31 IgG glycosylation; CRC cis rs17854409 1.000 rs16983290 chr20:61478894 A/G cg05147244 chr20:61493195 TCFL5 -0.58 -6.01 -0.31 4.9e-9 Obesity-related traits; CRC trans rs2303319 0.504 rs1006428 chr2:162592559 A/C cg10498984 chr16:28874827 SH2B1 -0.73 -6.3 -0.33 9.75e-10 Cognitive function; CRC cis rs10071761 0.597 rs116129874 chr5:40370481 A/G cg09067459 chr5:40385259 NA -0.52 -7.06 -0.36 9.82e-12 Selective IgA deficiency; CRC cis rs7786808 0.615 rs4909212 chr7:158197037 G/T cg01191920 chr7:158217561 PTPRN2 -0.72 -11.72 -0.54 9.3e-27 Obesity-related traits; CRC cis rs758324 0.812 rs2088718 chr5:131179189 C/T cg25547332 chr5:131281432 NA 0.35 5.61 0.3 4.25e-8 Alzheimer's disease in APOE e4- carriers; CRC cis rs968567 0.539 rs174549 chr11:61571382 A/G cg06781209 chr11:61594997 FADS2 0.42 5.98 0.31 5.93e-9 Blood metabolite levels;Rheumatoid arthritis;Vitiligo;Glycerophospholipid levels; CRC cis rs6952808 0.692 rs10950473 chr7:1999453 G/A cg00106254 chr7:1943704 MAD1L1 -0.52 -7.5 -0.38 6.11e-13 Bipolar disorder and schizophrenia; CRC cis rs56283067 0.847 rs1552196 chr6:44698265 A/G cg18551225 chr6:44695536 NA 0.42 5.9 0.31 9.24e-9 Total body bone mineral density; CRC cis rs12024301 0.557 rs12066802 chr1:183647316 A/G cg11505048 chr1:183622726 RGL1;APOBEC4 -0.67 -6.08 -0.32 3.25e-9 Peripheral arterial disease (traffic-related air pollution interaction); CRC trans rs208520 0.690 rs12198297 chr6:66714665 G/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 1.05 14.77 0.63 3.05e-38 Exhaled nitric oxide output; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg20390613 chr1:12678355 DHRS3 0.42 6.18 0.32 1.87e-9 Intelligence (multi-trait analysis); CRC cis rs7772486 0.774 rs6930181 chr6:146180974 A/T cg23711669 chr6:146136114 FBXO30 -0.66 -11.45 -0.53 9e-26 Lobe attachment (rater-scored or self-reported); CRC cis rs644799 1.000 rs487609 chr11:95588102 T/G cg03916912 chr11:95522834 CEP57;FAM76B 0.96 18.39 0.71 1.93e-52 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs9368481 0.502 rs3933232 chr6:26877446 T/C cg18867708 chr6:26865862 GUSBL1 0.42 6.02 0.32 4.59e-9 Autism spectrum disorder or schizophrenia; CRC cis rs13191362 0.872 rs13196631 chr6:163001588 A/G cg23758597 chr6:163146217 PARK2 -0.56 -6.17 -0.32 1.98e-9 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs3931020 0.530 rs6668736 chr1:75234550 C/T cg10128416 chr1:75198403 TYW3;CRYZ 0.48 6.59 0.34 1.74e-10 Resistin levels; CRC cis rs751728 0.965 rs2013381 chr6:33763837 C/T cg25922239 chr6:33757077 LEMD2 0.62 9.84 0.48 3.5e-20 Crohn's disease; CRC cis rs10504229 0.512 rs117968470 chr8:58014651 C/G cg22535103 chr8:58192502 C8orf71 -0.64 -7.01 -0.36 1.34e-11 Developmental language disorder (linguistic errors); CRC cis rs1218582 0.774 rs1007170 chr1:154881461 G/A cg24250549 chr1:154909240 PMVK 0.59 9.61 0.47 2.02e-19 Prostate cancer; CRC cis rs911119 0.955 rs8115417 chr20:23605223 T/A cg16589663 chr20:23618590 CST3 0.45 6.35 0.33 7.25e-10 Chronic kidney disease; CRC cis rs7617773 0.780 rs35411187 chr3:48360017 C/G cg11946769 chr3:48343235 NME6 0.73 9.9 0.48 2.16e-20 Coronary artery disease; CRC cis rs4731207 0.596 rs11981797 chr7:124579451 T/A cg23710748 chr7:124431027 NA -0.39 -6.12 -0.32 2.67e-9 Cutaneous malignant melanoma; CRC cis rs3857067 0.804 rs6821438 chr4:95091911 A/G cg11021082 chr4:95130006 SMARCAD1 -0.49 -7.66 -0.39 2.12e-13 QT interval; CRC cis rs2239547 0.522 rs7652131 chr3:52997154 C/T cg11645453 chr3:52864694 ITIH4 0.52 9.0 0.44 1.87e-17 Schizophrenia; CRC cis rs9359856 0.510 rs2768940 chr6:90436319 A/G cg13799429 chr6:90582589 CASP8AP2 -0.78 -10.24 -0.49 1.49e-21 Bipolar disorder; CRC cis rs4862750 0.914 rs1346126 chr4:187876404 T/C cg27532560 chr4:187881888 NA -0.54 -9.92 -0.48 1.82e-20 Lobe attachment (rater-scored or self-reported); CRC cis rs1707322 0.721 rs6665808 chr1:46162283 C/T cg06784218 chr1:46089804 CCDC17 0.58 10.64 0.51 6.5e-23 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs55788414 0.929 rs66463064 chr16:81180995 T/C cg06400318 chr16:81190750 PKD1L2 -0.66 -6.45 -0.33 4.06e-10 Left ventricular obstructive tract defect (maternal effect); CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg04650786 chr6:108395545 OSTM1 -0.53 -6.55 -0.34 2.18e-10 Diisocyanate-induced asthma; CRC cis rs1878931 0.501 rs9635547 chr16:3416664 C/T cg26668626 chr16:3451006 ZNF174;ZNF434 0.68 9.22 0.45 3.55e-18 Body mass index (adult); CRC cis rs2204008 0.580 rs11174421 chr12:38105138 A/G cg26384229 chr12:38710491 ALG10B 0.68 8.46 0.42 8.72e-16 Bladder cancer; CRC cis rs2040771 0.804 rs1340958 chr22:19253332 A/G cg02655711 chr22:19163373 SLC25A1 -0.5 -8.05 -0.41 1.55e-14 Metabolite levels (small molecules and protein measures); CRC trans rs1997103 1.000 rs2331065 chr7:55408392 A/G cg20935933 chr6:143382018 AIG1 0.51 6.65 0.34 1.25e-10 QRS interval (sulfonylurea treatment interaction); CRC cis rs12476592 0.602 rs262504 chr2:63861235 C/G cg10828910 chr2:63850056 LOC388955 0.49 6.04 0.32 4.23e-9 Childhood ear infection; CRC trans rs11039798 0.660 rs717897 chr11:48375604 A/G cg15704280 chr7:45808275 SEPT13 -0.63 -6.64 -0.34 1.29e-10 Axial length; CRC cis rs6963495 0.799 rs73190201 chr7:105165891 A/C cg13798780 chr7:105162888 PUS7 0.69 8.2 0.41 5.36e-15 Bipolar disorder (body mass index interaction); CRC trans rs16934284 0.764 rs58399611 chr9:119851764 C/A cg16808373 chr11:122850140 BSX -0.39 -6.14 -0.32 2.42e-9 Obesity-related traits; CRC cis rs10875746 0.951 rs11168433 chr12:48558064 C/G cg26205652 chr12:48591994 NA 0.46 5.62 0.3 4.01e-8 Longevity (90 years and older); CRC trans rs1376359 0.636 rs7533566 chr1:103123172 C/A cg16220183 chr17:56609687 SEPT4 -0.47 -6.48 -0.34 3.34e-10 QRS duration in Tripanosoma cruzi seropositivity; CRC cis rs1448094 0.512 rs12305828 chr12:86249153 C/G cg02569458 chr12:86230093 RASSF9 0.43 7.41 0.38 1.06e-12 Major depressive disorder; CRC trans rs35110281 0.720 rs162392 chr21:44941406 A/G cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.49 8.12 0.41 9.71e-15 Mean corpuscular volume; CRC cis rs17092148 0.887 rs6142199 chr20:33162298 G/C cg08999081 chr20:33150536 PIGU 0.5 6.48 0.34 3.41e-10 Neuroticism; CRC cis rs754466 0.606 rs56402185 chr10:79585848 G/A cg26805224 chr10:79626177 DLG5 -0.49 -7.0 -0.36 1.48e-11 Liver enzyme levels (gamma-glutamyl transferase); CRC trans rs3960554 0.808 rs11983987 chr7:75657850 A/G cg19862616 chr7:65841803 NCRNA00174 0.63 7.33 0.37 1.8e-12 Eotaxin levels; CRC trans rs7395662 1.000 rs1605364 chr11:48684843 G/T cg21153622 chr11:89784906 NA -0.44 -7.09 -0.36 8.39e-12 HDL cholesterol; CRC cis rs10905065 0.866 rs10795547 chr10:5827074 A/G cg11519256 chr10:5708881 ASB13 -0.5 -7.53 -0.38 4.96e-13 Menopause (age at onset); CRC cis rs2197308 0.715 rs11181816 chr12:37911626 A/G cg13010199 chr12:38710504 ALG10B -0.47 -6.92 -0.36 2.32e-11 Morning vs. evening chronotype; CRC cis rs1865760 0.613 rs2071300 chr6:25914572 C/T cg03517284 chr6:25882590 NA -0.43 -6.27 -0.33 1.14e-9 Height; CRC cis rs4713118 0.588 rs200994 chr6:27813813 A/C cg12273811 chr6:28175739 NA -0.55 -7.25 -0.37 2.96e-12 Parkinson's disease; CRC cis rs2276314 1.000 rs1540042 chr18:33555236 C/T cg05985134 chr18:33552581 C18orf21 0.46 6.36 0.33 6.7e-10 Endometriosis;Drug-induced torsades de pointes; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg06589161 chr5:180618230 NA -0.41 -6.15 -0.32 2.23e-9 Myopia (pathological); CRC cis rs1218582 0.741 rs10908447 chr1:154869742 C/T cg09359103 chr1:154839909 KCNN3 -0.75 -12.41 -0.56 2.94e-29 Prostate cancer; CRC cis rs807029 0.577 rs7903239 chr10:102758337 G/T cg04662943 chr10:102668895 NA 0.61 7.13 0.37 6.44e-12 Ejection fraction in Tripanosoma cruzi seropositivity; CRC cis rs7586879 0.639 rs7580081 chr2:25097072 G/C cg22495460 chr2:25135724 ADCY3 -0.84 -16.07 -0.66 2.73e-43 Body mass index; CRC cis rs1577917 1.000 rs1018184 chr6:86648475 G/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A 0.51 6.78 0.35 5.54e-11 Response to antipsychotic treatment; CRC cis rs34172651 0.517 rs200528 chr16:24759131 A/G cg06505273 chr16:24850292 NA -0.52 -6.7 -0.35 9.01e-11 Intelligence (multi-trait analysis); CRC trans rs8005150 0.737 rs8016427 chr14:88484544 T/C cg25527770 chr19:1444892 NA -0.56 -6.03 -0.32 4.36e-9 Hepatitis B; CRC cis rs1129187 0.791 rs1129186 chr6:42932202 C/T cg00597713 chr6:42947103 PEX6 -0.41 -5.83 -0.31 1.3e-8 Alzheimer's disease in APOE e4+ carriers; CRC cis rs881375 0.967 rs2109895 chr9:123677827 C/T cg09419670 chr9:123605666 PSMD5;LOC253039 0.59 8.73 0.43 1.34e-16 Rheumatoid arthritis; CRC cis rs35110281 0.714 rs7277539 chr21:45053011 A/G cg01579765 chr21:45077557 HSF2BP -0.38 -7.32 -0.37 1.86e-12 Mean corpuscular volume; CRC cis rs6764363 0.527 rs13078683 chr3:275511 T/G cg02057681 chr3:285234 CHL1 0.4 6.68 0.35 1.01e-10 Sudden cardiac arrest; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg05778739 chr2:96676295 LOC729234 0.42 6.13 0.32 2.58e-9 Intelligence (multi-trait analysis); CRC cis rs57677839 1 rs57677839 chr11:17028189 G/A cg15084286 chr11:17036142 PLEKHA7 0.9 16.44 0.67 9.58e-45 Coronary artery disease; CRC cis rs2576037 0.901 rs2576036 chr18:44587102 G/T cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.42 -6.4 -0.33 5.41e-10 Personality dimensions; CRC cis rs7772486 0.590 rs1890170 chr6:146071839 G/C cg13319975 chr6:146136371 FBXO30 0.63 9.12 0.45 7.53e-18 Lobe attachment (rater-scored or self-reported); CRC cis rs9381040 1.000 rs9381040 chr6:41154650 C/T cg04346459 chr6:41068666 NFYA;LOC221442 -0.41 -5.73 -0.3 2.26e-8 Alzheimer's disease (late onset); CRC cis rs6424115 0.793 rs2502998 chr1:24198327 T/A cg15997130 chr1:24165203 NA 0.72 10.69 0.51 4.31e-23 Immature fraction of reticulocytes; CRC cis rs1448094 0.556 rs11610789 chr12:86169541 A/G cg00310523 chr12:86230176 RASSF9 0.42 6.83 0.35 4.13e-11 Major depressive disorder; CRC trans rs1376359 0.636 rs6669473 chr1:103114350 C/T cg16220183 chr17:56609687 SEPT4 -0.48 -6.63 -0.34 1.36e-10 QRS duration in Tripanosoma cruzi seropositivity; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg11604912 chr11:67163072 RAD9A -0.4 -7.24 -0.37 3.18e-12 Liver disease severity in Alagille syndrome; CRC cis rs1865760 0.663 rs9379815 chr6:25980116 T/A cg16482183 chr6:26056742 HIST1H1C 0.5 7.43 0.38 9.73e-13 Height; CRC cis rs10504229 1.000 rs77120900 chr8:58170368 C/T cg02290350 chr8:58132656 NA -0.42 -5.96 -0.31 6.62e-9 Developmental language disorder (linguistic errors); CRC cis rs9368481 0.761 rs9379952 chr6:26987900 A/T cg18867708 chr6:26865862 GUSBL1 -0.42 -5.98 -0.31 5.82e-9 Autism spectrum disorder or schizophrenia; CRC cis rs9649213 0.593 rs6465677 chr7:98003552 C/T cg21770322 chr7:97807741 LMTK2 0.51 8.29 0.42 2.98e-15 Prostate cancer (SNP x SNP interaction); CRC cis rs2072499 0.966 rs1137703 chr1:156184458 T/C cg24450063 chr1:156163899 SLC25A44 1.15 27.07 0.83 1.05e-85 Testicular germ cell tumor; CRC cis rs40363 0.645 rs250627 chr16:3527050 G/A cg05754148 chr16:3507555 NAT15 0.47 6.61 0.34 1.52e-10 Tuberculosis; CRC cis rs4969178 0.930 rs11077363 chr17:76397309 C/T cg05887092 chr17:76393375 PGS1 0.55 10.0 0.48 1.01e-20 HDL cholesterol levels; CRC trans rs7395662 1.000 rs4882010 chr11:48559173 T/G cg21153622 chr11:89784906 NA -0.45 -7.24 -0.37 3.25e-12 HDL cholesterol; CRC cis rs11997175 0.583 rs17780571 chr8:33817821 G/C cg04338863 chr8:33670619 NA 0.44 6.52 0.34 2.67e-10 Body mass index; CRC trans rs10028773 0.666 rs35231872 chr4:120248376 A/T cg25214090 chr10:38739885 LOC399744 0.54 8.16 0.41 7.12e-15 Educational attainment; CRC cis rs853679 0.760 rs9393910 chr6:28208192 C/G cg02683197 chr6:28174875 NA 0.64 6.54 0.34 2.37e-10 Depression; CRC cis rs7617773 1.000 rs6442106 chr3:48190815 G/A cg11946769 chr3:48343235 NME6 -0.46 -6.43 -0.33 4.53e-10 Coronary artery disease; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg07355693 chr12:125667907 NA 0.43 6.32 0.33 8.44e-10 Response to antipsychotic treatment; CRC cis rs453301 0.686 rs2409120 chr8:8882571 G/C cg14979609 chr8:8086686 FLJ10661 0.37 5.92 0.31 7.97e-9 Joint mobility (Beighton score); CRC cis rs1003719 0.679 rs1133001 chr21:38512956 A/G cg10648535 chr21:38446584 PIGP;TTC3 -0.48 -6.68 -0.35 1.03e-10 Eye color traits; CRC cis rs9915657 0.933 rs8075603 chr17:70136833 G/T cg09344028 chr17:70110421 NA 0.48 7.55 0.38 4.36e-13 Thyroid hormone levels; CRC cis rs2282802 0.685 rs13177186 chr5:139640476 A/G cg26211634 chr5:139558579 C5orf32 0.41 6.94 0.36 2.15e-11 Intelligence (multi-trait analysis); CRC trans rs9291683 0.588 rs12507330 chr4:10002195 G/A cg26043149 chr18:55253948 FECH 0.49 7.76 0.39 1.05e-13 Bone mineral density; CRC trans rs2303319 0.504 rs1023835 chr2:162593973 A/G cg22988483 chr14:93581567 ITPK1 -0.66 -6.07 -0.32 3.52e-9 Cognitive function; CRC cis rs11212617 0.967 rs419716 chr11:108221099 G/T cg12106634 chr11:108092400 ATM;NPAT -0.42 -6.32 -0.33 8.45e-10 Response to metformin in type 2 diabetes (glycemic); CRC trans rs800082 0.507 rs2717379 chr3:144256805 G/A cg24215973 chr2:240111563 HDAC4 0.44 6.1 0.32 2.97e-9 Smoking behavior; CRC cis rs4819052 0.851 rs28676615 chr21:46676576 G/C cg02159808 chr21:46707872 POFUT2;LOC642852 0.53 6.94 0.36 2.05e-11 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg04254693 chr3:49727222 MST1;RNF123 0.46 6.02 0.31 4.75e-9 Thyroid stimulating hormone; CRC cis rs7937682 0.632 rs2070894 chr11:111780837 G/A cg09085632 chr11:111637200 PPP2R1B 0.94 14.72 0.63 5.16e-38 Primary sclerosing cholangitis; CRC cis rs769267 0.896 rs11882123 chr19:19386339 A/G cg02546618 chr19:19431379 KIAA0892;SF4 0.46 6.3 0.33 9.51e-10 Tonsillectomy; CRC cis rs7615952 0.576 rs6804482 chr3:125815762 C/T cg18479299 chr3:125709523 NA -0.56 -6.64 -0.34 1.3e-10 Blood pressure (smoking interaction); CRC trans rs2303319 0.504 rs1023835 chr2:162593973 A/G cg13490827 chr1:46269305 MAST2 -0.69 -6.0 -0.31 5.24e-9 Cognitive function; CRC trans rs6557786 0.636 rs17052934 chr8:24840319 A/C cg01273802 chr8:10871371 XKR6 0.32 6.23 0.32 1.44e-9 Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 2 peripheral neuropathy); CRC cis rs6860806 0.507 rs274572 chr5:131710917 T/G cg22638593 chr5:131593259 PDLIM4 -0.39 -6.36 -0.33 6.75e-10 Breast cancer; CRC cis rs2739330 0.828 rs2877178 chr22:24251517 C/T cg23131131 chr22:24373011 LOC391322 -0.66 -10.13 -0.49 3.48e-21 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs2153535 0.580 rs9505457 chr6:8479142 C/T cg07606381 chr6:8435919 SLC35B3 0.67 10.69 0.51 4.33e-23 Motion sickness; CRC cis rs6570726 0.935 rs409725 chr6:145840340 G/A cg05347473 chr6:146136440 FBXO30 0.37 6.0 0.31 5.27e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs13315871 0.929 rs9837903 chr3:58301906 A/T cg20936604 chr3:58311152 NA -0.72 -6.86 -0.35 3.51e-11 Cholesterol, total; CRC cis rs17001868 0.568 rs9607699 chr22:40737036 G/A cg07138101 chr22:40742427 ADSL 0.59 7.84 0.4 6.24e-14 Mammographic density (dense area); CRC cis rs4665809 1.000 rs4665299 chr2:26256840 A/C cg26119090 chr2:26468346 HADHA;HADHB -0.67 -8.31 -0.42 2.6e-15 Gut microbiome composition (summer); CRC trans rs1656966 1.000 rs1656966 chr3:186466252 C/T cg24413235 chr2:27851648 CCDC121;GPN1 0.42 6.3 0.33 9.81e-10 Myopia (pathological); CRC cis rs2204008 0.592 rs2320501 chr12:38145285 T/G cg13010199 chr12:38710504 ALG10B 0.47 6.08 0.32 3.41e-9 Bladder cancer; CRC cis rs12477438 0.520 rs1133978 chr2:99741964 C/T cg26064155 chr2:99771622 LIPT1;TSGA10 0.77 12.97 0.58 2.38e-31 Chronic sinus infection; CRC cis rs7772486 0.686 rs9390347 chr6:146044747 G/T cg13319975 chr6:146136371 FBXO30 0.43 6.45 0.34 3.96e-10 Lobe attachment (rater-scored or self-reported); CRC cis rs364477 0.904 rs420061 chr9:957951 C/G cg13952963 chr9:998547 NA 0.54 5.76 0.3 1.89e-8 Major depressive disorder; CRC cis rs8062405 0.690 rs62034351 chr16:28565489 G/A cg16576597 chr16:28551801 NUPR1 0.5 6.8 0.35 4.8e-11 Cognitive ability (multi-trait analysis);Cognitive ability; CRC cis rs4819052 0.851 rs1056101 chr21:46678702 C/G cg19498844 chr21:46707878 POFUT2;LOC642852 0.75 10.83 0.51 1.35e-23 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs6502050 0.731 rs9892653 chr17:80100191 G/T cg25804541 chr17:80189381 SLC16A3 -0.31 -5.97 -0.31 6.08e-9 Life satisfaction; CRC cis rs6662572 0.686 rs11805376 chr1:46559664 C/G cg08644498 chr1:46502608 NA 0.46 7.36 0.38 1.45e-12 Blood protein levels; CRC cis rs9828933 0.678 rs704366 chr3:63871648 A/G cg16258503 chr3:63850278 ATXN7;THOC7 0.53 5.62 0.3 4.18e-8 Type 2 diabetes; CRC cis rs9875589 0.509 rs56071023 chr3:14075920 A/G cg14375111 chr3:14165186 TMEM43;CHCHD4 0.39 6.02 0.31 4.77e-9 Ovarian reserve; CRC cis rs2108225 0.658 rs1476673 chr7:107435945 C/G cg18560240 chr7:107437656 SLC26A3 -0.61 -9.48 -0.46 5.43e-19 Ulcerative colitis; CRC cis rs71403859 0.504 rs12926413 chr16:71972325 T/C cg08717414 chr16:71523259 ZNF19 -0.83 -7.11 -0.36 7.48e-12 Post bronchodilator FEV1; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg10649384 chr7:87505489 SLC25A40;DBF4 0.36 6.06 0.32 3.75e-9 Liver disease severity in Alagille syndrome; CRC cis rs6496667 0.821 rs79731978 chr15:90876013 G/A cg04176472 chr15:90893244 GABARAPL3 0.62 7.32 0.37 1.93e-12 Rheumatoid arthritis; CRC cis rs12249377 0.519 rs11186320 chr10:92576448 C/T cg14313238 chr10:92632228 RPP30 -0.44 -5.8 -0.3 1.54e-8 White matter microstructure (global fractional anisotropy); CRC cis rs7809950 0.593 rs62482503 chr7:106987988 A/G cg23024343 chr7:107201750 COG5 -0.7 -9.55 -0.47 3.18e-19 Coronary artery disease; CRC cis rs1953600 0.870 rs2573356 chr10:81949363 C/T cg00277334 chr10:82204260 NA 0.37 5.91 0.31 8.4e-9 Sarcoidosis; CRC trans rs10435719 0.902 rs6601633 chr8:11805173 C/T cg08975724 chr8:8085496 FLJ10661 -0.41 -6.34 -0.33 7.74e-10 C-reactive protein levels or triglyceride levels (pleiotropy); CRC cis rs8060686 0.544 rs1124993 chr16:68114626 T/C cg08314208 chr16:67682810 RLTPR -0.49 -5.97 -0.31 5.98e-9 HDL cholesterol;Metabolic syndrome; CRC cis rs6502050 0.835 rs9646397 chr17:80083534 G/A cg19223190 chr17:80058835 NA -0.39 -6.24 -0.33 1.31e-9 Life satisfaction; CRC cis rs56399783 0.901 rs17132624 chr7:2778496 G/A cg19731401 chr7:2775893 GNA12 0.67 7.26 0.37 2.84e-12 Childhood ear infection; CRC cis rs7762018 0.891 rs7764839 chr6:170146351 C/A cg17545662 chr6:170176663 C6orf70 0.57 6.45 0.34 3.99e-10 Thiazide-induced adverse metabolic effects in hypertensive patients; CRC cis rs4566357 0.615 rs3769645 chr2:227913717 A/G cg11843606 chr2:227700838 RHBDD1 -0.43 -6.77 -0.35 6.06e-11 Coronary artery disease; CRC cis rs9393692 0.875 rs9393690 chr6:26271713 A/T cg13736514 chr6:26305472 NA -0.62 -11.54 -0.54 4.28e-26 Educational attainment; CRC cis rs728616 0.867 rs61859022 chr10:81860799 G/A cg05935833 chr10:81318306 SFTPA2 -0.61 -6.94 -0.36 2.15e-11 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs1862618 0.671 rs2591958 chr5:56239369 C/G cg24531977 chr5:56204891 C5orf35 0.66 10.22 0.49 1.74e-21 Initial pursuit acceleration; CRC cis rs7618915 0.547 rs11714419 chr3:52628816 A/G cg07507251 chr3:52567010 NT5DC2 0.45 6.49 0.34 3.08e-10 Bipolar disorder; CRC cis rs45544231 0.569 rs3095605 chr16:52583847 A/G cg09051775 chr16:52580266 TOX3 -0.42 -6.59 -0.34 1.74e-10 Restless legs syndrome; CRC cis rs1862618 0.853 rs1559282 chr5:56099375 T/A cg03609598 chr5:56110824 MAP3K1 -0.8 -9.78 -0.47 5.44e-20 Initial pursuit acceleration; CRC cis rs11758351 0.587 rs16891456 chr6:26234127 T/C cg08260959 chr6:26240920 HIST1H4F -0.35 -5.73 -0.3 2.24e-8 Gout;Renal underexcretion gout; CRC cis rs1799949 1.000 rs3092994 chr17:41215825 C/T cg19454999 chr17:41278357 BRCA1;NBR2 0.54 8.55 0.43 4.83e-16 Menopause (age at onset); CRC cis rs6912958 0.754 rs6918909 chr6:88247251 A/C cg08069147 chr6:88032118 GJB7;C6orf162 -0.54 -8.01 -0.4 1.96e-14 Monocyte percentage of white cells; CRC cis rs3741151 0.656 rs10501411 chr11:73292085 A/C cg17517138 chr11:73019481 ARHGEF17 0.85 7.38 0.38 1.29e-12 GIP levels in response to oral glucose tolerance test (120 minutes); CRC cis rs801193 1.000 rs2659915 chr7:66153101 A/G cg00343986 chr7:65444356 GUSB 0.48 7.33 0.37 1.79e-12 Aortic root size; CRC cis rs6951245 1.000 rs6951245 chr7:1058193 G/A cg20603222 chr7:1096387 C7orf50;GPR146 -0.66 -7.75 -0.39 1.19e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs11122272 0.735 rs2491407 chr1:231518928 G/A cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.54 -8.09 -0.41 1.18e-14 Hemoglobin concentration; CRC cis rs938554 0.577 rs4591605 chr4:10002719 T/C cg00071950 chr4:10020882 SLC2A9 0.48 6.6 0.34 1.63e-10 Blood metabolite levels; CRC cis rs17376456 0.877 rs9314093 chr5:93333347 G/A cg21475434 chr5:93447410 FAM172A 0.78 7.75 0.39 1.17e-13 Diabetic retinopathy; CRC cis rs2762353 0.595 rs13194155 chr6:25755508 C/T cg03264133 chr6:25882463 NA 0.72 10.08 0.49 5.16e-21 Blood metabolite levels; CRC cis rs1552244 0.872 rs115331527 chr3:10154504 G/A cg08888203 chr3:10149979 C3orf24 0.73 9.89 0.48 2.26e-20 Alzheimer's disease; CRC cis rs73200209 0.744 rs7314858 chr12:116565050 T/C cg01776926 chr12:116560359 MED13L -0.61 -7.16 -0.37 5.26e-12 Total body bone mineral density; CRC cis rs9515201 0.627 rs4773173 chr13:111025118 A/G cg06243866 chr13:111019493 COL4A2 -0.43 -6.53 -0.34 2.54e-10 White matter hyperintensity burden; CRC cis rs4862750 0.794 rs7692427 chr4:187901727 G/A cg03647317 chr4:187891568 NA -0.54 -10.28 -0.49 1.09e-21 Lobe attachment (rater-scored or self-reported); CRC trans rs11098499 0.754 rs2964 chr4:120240131 T/C cg25214090 chr10:38739885 LOC399744 0.53 8.45 0.42 9.68e-16 Corneal astigmatism; CRC cis rs6860806 0.531 rs272888 chr5:131665423 T/C cg20512303 chr5:131592959 PDLIM4 0.39 6.76 0.35 6.38e-11 Breast cancer; CRC cis rs6901250 0.788 rs571296 chr6:117092558 A/G cg12892004 chr6:117198278 RFX6 -0.37 -5.82 -0.31 1.4e-8 C-reactive protein levels; CRC cis rs270601 0.837 rs367805 chr5:131701279 T/C cg20512303 chr5:131592959 PDLIM4 0.38 6.52 0.34 2.6e-10 Acylcarnitine levels; CRC cis rs270601 0.710 rs4705852 chr5:131602807 A/G cg22638593 chr5:131593259 PDLIM4 0.49 9.08 0.45 1.05e-17 Acylcarnitine levels; CRC cis rs13108904 0.846 rs12643212 chr4:1224948 A/G cg05665937 chr4:1216051 CTBP1 0.47 7.15 0.37 5.75e-12 Obesity-related traits; CRC trans rs35110281 0.548 rs7276316 chr21:45029333 A/T cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.49 8.05 0.41 1.53e-14 Mean corpuscular volume; CRC cis rs1799949 1.000 rs8176126 chr17:41259049 A/G cg05368731 chr17:41323189 NBR1 -0.69 -10.57 -0.5 1.09e-22 Menopause (age at onset); CRC cis rs9308731 0.644 rs56952027 chr2:111877104 C/T cg04202892 chr2:111875749 ACOXL 0.43 7.03 0.36 1.21e-11 Chronic lymphocytic leukemia; CRC cis rs9611519 0.808 rs5751074 chr22:41665722 G/A cg06634786 chr22:41940651 POLR3H -0.43 -5.77 -0.3 1.83e-8 Neuroticism; CRC cis rs13217239 0.646 rs10456351 chr6:26986792 C/T cg12292205 chr6:26970375 C6orf41 0.56 9.32 0.46 1.78e-18 Schizophrenia; CRC cis rs7119 0.717 rs12910594 chr15:77817103 G/A cg27398640 chr15:77910606 LINGO1 -0.43 -7.47 -0.38 7.13e-13 Type 2 diabetes; CRC trans rs10504229 1.000 rs6989060 chr8:58178989 T/G cg04077850 chr5:125800366 GRAMD3 0.37 6.27 0.33 1.15e-9 Developmental language disorder (linguistic errors); CRC cis rs8072100 0.817 rs11869940 chr17:45578435 T/A cg25173405 chr17:45401733 C17orf57 0.47 7.39 0.38 1.2e-12 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs425277 0.628 rs262662 chr1:2085033 A/G cg24578937 chr1:2090814 PRKCZ 0.43 7.67 0.39 1.95e-13 Height; CRC cis rs9287719 0.935 rs7600495 chr2:10739800 A/G cg00105475 chr2:10696890 NA 0.45 7.3 0.37 2.19e-12 Prostate cancer; CRC cis rs4713118 0.696 rs2394002 chr6:27748015 G/A cg08798685 chr6:27730294 NA -0.48 -6.64 -0.34 1.27e-10 Parkinson's disease; CRC cis rs977987 0.864 rs37595 chr16:75496963 G/C cg03315344 chr16:75512273 CHST6 -0.58 -9.62 -0.47 1.8e-19 Dupuytren's disease; CRC cis rs8060686 0.920 rs73593810 chr16:67866783 C/T cg08314208 chr16:67682810 RLTPR -0.65 -7.38 -0.38 1.34e-12 HDL cholesterol;Metabolic syndrome; CRC cis rs375066 0.592 rs349048 chr19:44300937 C/T cg11993925 chr19:44307056 LYPD5 -0.38 -6.18 -0.32 1.9e-9 Breast cancer; CRC cis rs7762018 0.607 rs6907814 chr6:170058206 G/A cg24289452 chr6:170231220 NA -0.77 -6.87 -0.35 3.18e-11 Thiazide-induced adverse metabolic effects in hypertensive patients; CRC cis rs933688 1.000 rs60513756 chr5:90727692 A/C cg02339078 chr5:90679543 LOC100129716;ARRDC3 0.89 13.66 0.6 5.9e-34 Smoking behavior; CRC cis rs4728302 0.594 rs6978383 chr7:133721697 G/A cg03336402 chr7:133662267 EXOC4 -0.43 -6.67 -0.34 1.11e-10 Intelligence;Intelligence (multi-trait analysis); CRC cis rs6582630 0.539 rs35114325 chr12:38320886 G/T cg26384229 chr12:38710491 ALG10B -0.53 -7.8 -0.4 8.03e-14 Drug-induced liver injury (flucloxacillin); CRC cis rs7937682 0.593 rs1944117 chr11:111351184 T/C cg09085632 chr11:111637200 PPP2R1B 0.42 5.84 0.31 1.28e-8 Primary sclerosing cholangitis; CRC cis rs2708977 0.699 rs631746 chr2:97065499 A/G cg23100626 chr2:96804247 ASTL 0.25 6.56 0.34 2.1e-10 Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes; CRC cis rs651907 0.557 rs34947019 chr3:101532235 C/T cg12386194 chr3:101231763 SENP7 0.51 7.36 0.38 1.49e-12 Colorectal cancer; CRC cis rs9649465 1.000 rs2109725 chr7:123325459 C/T cg03229431 chr7:123269106 ASB15 -0.36 -5.64 -0.3 3.7e-8 Migraine; CRC cis rs8180040 0.966 rs7651762 chr3:47470484 G/A cg10298567 chr3:47292165 KIF9 0.38 6.01 0.31 4.81e-9 Colorectal cancer; CRC cis rs10982256 0.875 rs1535962 chr9:117259062 T/C cg13636371 chr9:117264095 DFNB31 0.41 7.72 0.39 1.44e-13 Bipolar disorder; CRC cis rs10504229 0.683 rs7459925 chr8:58111771 G/A cg24829409 chr8:58192753 C8orf71 -0.55 -7.9 -0.4 4.11e-14 Developmental language disorder (linguistic errors); CRC cis rs440932 0.887 rs398801 chr8:9031704 A/T cg06636001 chr8:8085503 FLJ10661 -0.58 -8.42 -0.42 1.2e-15 High light scatter reticulocyte percentage of red cells; CRC cis rs4285028 0.948 rs2332033 chr3:121699548 C/T cg11130432 chr3:121712080 ILDR1 -0.5 -6.53 -0.34 2.48e-10 Multiple sclerosis; CRC cis rs992157 0.798 rs7557709 chr2:219167529 G/A cg13835894 chr2:219148914 PNKD;TMBIM1 0.33 6.2 0.32 1.65e-9 Colorectal cancer; CRC cis rs7737355 0.947 rs7706785 chr5:130954860 T/C cg06307176 chr5:131281290 NA 0.45 6.44 0.33 4.35e-10 Life satisfaction; CRC cis rs7615952 0.599 rs12486459 chr3:125741465 T/G cg18479299 chr3:125709523 NA -0.54 -6.28 -0.33 1.04e-9 Blood pressure (smoking interaction); CRC cis rs17125944 0.686 rs78623109 chr14:53383077 G/T cg00686598 chr14:53173677 PSMC6 0.78 6.28 0.33 1.06e-9 Alzheimer's disease (late onset); CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg14824280 chr20:60718867 SS18L1;PSMA7 0.44 6.19 0.32 1.84e-9 Anxiety disorder; CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg07140808 chr4:78978772 FRAS1 -0.56 -6.9 -0.36 2.68e-11 Diisocyanate-induced asthma; CRC cis rs7917772 0.619 rs2801050 chr10:104509393 T/A cg11453585 chr10:104263688 ACTR1A;SUFU 0.77 11.12 0.52 1.29e-24 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC cis rs6952808 0.723 rs4721282 chr7:2025040 A/G cg04267008 chr7:1944627 MAD1L1 -0.68 -9.76 -0.47 6.15e-20 Bipolar disorder and schizophrenia; CRC cis rs801193 1.000 rs2055682 chr7:66260289 A/G cg00343986 chr7:65444356 GUSB 0.44 6.42 0.33 4.69e-10 Aortic root size; CRC cis rs2797160 1.000 rs2747714 chr6:126007620 A/G cg05901451 chr6:126070800 HEY2 0.4 6.17 0.32 1.99e-9 Endometrial cancer; CRC cis rs7086627 0.515 rs10887903 chr10:82210641 C/T cg00277334 chr10:82204260 NA -0.83 -17.25 -0.69 5.83e-48 Post bronchodilator FEV1; CRC trans rs7395662 1.000 rs7395662 chr11:48518893 C/T cg21153622 chr11:89784906 NA 0.44 7.1 0.36 7.65e-12 HDL cholesterol; CRC cis rs367943 0.965 rs458044 chr5:112797779 A/G cg12552261 chr5:112820674 MCC -0.49 -7.7 -0.39 1.6e-13 Type 2 diabetes; CRC trans rs11148252 0.574 rs9536247 chr13:53279542 T/C cg18335740 chr13:41363409 SLC25A15 0.79 14.4 0.62 8.33e-37 Lewy body disease; CRC cis rs9487051 0.872 rs9400271 chr6:109607556 G/A cg01475377 chr6:109611718 NA -0.49 -9.21 -0.45 3.86e-18 Reticulocyte fraction of red cells; CRC cis rs12477438 0.765 rs12470471 chr2:99689141 A/T cg14399236 chr2:99771627 LIPT1;TSGA10 0.58 7.9 0.4 4.19e-14 Chronic sinus infection; CRC trans rs2243480 0.708 rs781141 chr7:65438553 A/G cg10756647 chr7:56101905 PSPH 0.73 8.14 0.41 8.01e-15 Diabetic kidney disease; CRC cis rs7119 0.717 rs62009071 chr15:77817886 C/G cg10437265 chr15:77819839 NA 0.69 12.74 0.57 1.76e-30 Type 2 diabetes; CRC cis rs7727544 0.571 rs12521097 chr5:131575338 G/A cg12564285 chr5:131593104 PDLIM4 0.36 6.93 0.36 2.21e-11 Blood metabolite levels; CRC trans rs9291683 0.618 rs13137343 chr4:10043028 C/A cg26043149 chr18:55253948 FECH 0.53 8.17 0.41 6.72e-15 Bone mineral density; CRC cis rs8046696 1 rs8046696 chr16:75442143 T/G cg03315344 chr16:75512273 CHST6 0.55 9.29 0.46 2.16e-18 Coronary artery disease; CRC cis rs736801 0.521 rs2070729 chr5:131819921 G/T cg00255919 chr5:131827918 IRF1 0.47 9.12 0.45 7.63e-18 Breast cancer;Mosquito bite size; CRC cis rs17767392 0.958 rs36072220 chr14:71980744 A/T cg13720639 chr14:72061746 SIPA1L1 -0.57 -7.29 -0.37 2.34e-12 Mitral valve prolapse; CRC cis rs853679 0.517 rs9295759 chr6:28124469 C/T cg02631126 chr6:28058918 ZSCAN12L1 0.29 5.91 0.31 8.38e-9 Depression; CRC cis rs1401999 0.659 rs4912518 chr3:183752027 C/T cg20387954 chr3:183756860 HTR3D -0.36 -6.12 -0.32 2.67e-9 Anterior chamber depth; CRC trans rs951252 0.504 rs11734405 chr4:146081096 C/T cg11224423 chr12:56136943 GDF11 0.46 6.14 0.32 2.35e-9 Hip circumference; CRC cis rs2294693 0.786 rs12055704 chr6:40988504 C/T cg14769373 chr6:40998127 UNC5CL -0.51 -6.18 -0.32 1.9e-9 Gastric cancer;Non-cardia gastric cancer; CRC cis rs117623576 0.941 rs17230152 chr10:32431969 A/G cg03047570 chr10:32398778 NA -0.68 -6.82 -0.35 4.3e-11 Anti-saccade response; CRC cis rs1552244 1.000 rs6442150 chr3:10122575 T/C cg16606324 chr3:10149918 C3orf24 0.72 9.82 0.48 3.92e-20 Alzheimer's disease; CRC cis rs4555082 0.834 rs2735819 chr14:105713449 C/T cg13114125 chr14:105738426 BRF1 -0.8 -11.87 -0.55 2.77e-27 Mean platelet volume;Platelet distribution width; CRC cis rs4731207 0.596 rs10244797 chr7:124571684 C/T cg23710748 chr7:124431027 NA -0.43 -6.69 -0.35 9.89e-11 Cutaneous malignant melanoma; CRC cis rs921968 0.541 rs585185 chr2:219457741 G/A cg02176678 chr2:219576539 TTLL4 0.54 8.62 0.43 2.78e-16 Mean corpuscular hemoglobin concentration; CRC cis rs1008375 0.931 rs1860592 chr4:17577028 C/G cg16339924 chr4:17578868 LAP3 0.6 7.91 0.4 3.86e-14 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs72781680 0.611 rs72797810 chr2:24336469 G/A cg20701182 chr2:24300061 SF3B14 0.61 7.43 0.38 9.64e-13 Lymphocyte counts; CRC cis rs853679 0.546 rs200995 chr6:27813694 C/T cg15845792 chr6:28175446 NA -0.75 -6.47 -0.34 3.6e-10 Depression; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg10016835 chr1:29557393 MECR 0.43 6.04 0.32 4.12e-9 Response to antipsychotic treatment; CRC cis rs73206853 0.841 rs56209636 chr12:110841998 T/C cg12870014 chr12:110450643 ANKRD13A 0.85 10.18 0.49 2.4e-21 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC cis rs6951245 1.000 rs75016635 chr7:1094121 G/A cg24642844 chr7:1081250 C7orf50 -0.78 -9.47 -0.46 5.57e-19 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs2075371 0.796 rs1978504 chr7:134006933 C/T cg02659138 chr7:134003124 SLC35B4 -0.42 -7.33 -0.37 1.74e-12 Mean platelet volume; CRC cis rs6758955 0.850 rs6758633 chr2:10480201 T/C cg15773312 chr2:10472214 HPCAL1 -0.82 -9.49 -0.46 5.01e-19 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; CRC cis rs896854 0.936 rs10108430 chr8:95961794 C/T cg23172400 chr8:95962367 TP53INP1 -0.48 -7.97 -0.4 2.59e-14 Type 2 diabetes; CRC cis rs6570726 0.791 rs418701 chr6:145889992 C/T cg13319975 chr6:146136371 FBXO30 -0.42 -6.22 -0.32 1.53e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs539096 0.500 rs2527776 chr1:44345292 G/A cg12908607 chr1:44402522 ARTN -0.55 -10.1 -0.49 4.61e-21 Intelligence (multi-trait analysis); CRC cis rs4969178 0.965 rs8075131 chr17:76394595 T/G cg20026190 chr17:76395443 PGS1 0.4 6.22 0.32 1.53e-9 HDL cholesterol levels; CRC trans rs7267979 1.000 rs6050629 chr20:25430680 G/A cg17903999 chr18:56338584 MALT1 -0.42 -6.98 -0.36 1.6e-11 Liver enzyme levels (alkaline phosphatase); CRC cis rs7666738 0.830 rs11097598 chr4:98946057 T/C cg17366294 chr4:99064904 C4orf37 0.43 7.34 0.38 1.69e-12 Colonoscopy-negative controls vs population controls; CRC cis rs13315871 0.929 rs9857333 chr3:58293551 G/C cg20936604 chr3:58311152 NA -0.72 -7.67 -0.39 1.95e-13 Cholesterol, total; CRC cis rs4911259 0.507 rs8118663 chr20:31398876 A/G cg11800794 chr20:31407338 MAPRE1 0.38 5.85 0.31 1.16e-8 Inflammatory bowel disease; CRC cis rs6964587 1.000 rs6952389 chr7:91657994 A/G cg17063962 chr7:91808500 NA 0.8 14.16 0.62 6.84e-36 Breast cancer; CRC trans rs2228479 0.702 rs17233868 chr16:89803629 C/T cg21302420 chr1:112162376 RAP1A 0.73 5.98 0.31 5.83e-9 Skin colour saturation; CRC cis rs9292777 1.000 rs9292777 chr5:40437948 C/T cg09067459 chr5:40385259 NA 0.52 9.43 0.46 7.59e-19 Crohn's disease;Multiple sclerosis; CRC cis rs929354 0.772 rs6954050 chr7:156978554 A/G cg17757837 chr7:157058334 UBE3C 0.74 12.6 0.57 5.83e-30 Body mass index; CRC cis rs2882667 0.690 rs288007 chr5:138230628 C/T cg09476006 chr5:138032270 NA 0.54 8.88 0.44 4.42e-17 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs10883723 0.773 rs2296578 chr10:104240974 C/G cg11453585 chr10:104263688 ACTR1A;SUFU 0.91 16.55 0.67 3.38e-45 Allergic disease (asthma, hay fever or eczema); CRC cis rs752010 0.668 rs10890147 chr1:42089725 A/T cg06885757 chr1:42089581 HIVEP3 0.69 11.8 0.55 4.9e-27 Lupus nephritis in systemic lupus erythematosus; CRC cis rs6502050 0.835 rs7222057 chr17:80087647 C/A cg22110888 chr17:80059540 CCDC57 0.41 6.38 0.33 6.11e-10 Life satisfaction; CRC cis rs72781680 0.898 rs17762609 chr2:24114729 G/T cg08917208 chr2:24149416 ATAD2B 0.87 8.59 0.43 3.46e-16 Lymphocyte counts; CRC cis rs9322193 0.923 rs11155683 chr6:150100477 T/C cg05861140 chr6:150128134 PCMT1 -0.43 -7.05 -0.36 1.03e-11 Lung cancer; CRC trans rs11098499 0.863 rs13149407 chr4:120437825 A/G cg25214090 chr10:38739885 LOC399744 0.64 10.02 0.48 8.38e-21 Corneal astigmatism; CRC cis rs2933343 0.700 rs2630257 chr3:128644015 T/C cg11901034 chr3:128598214 ACAD9 -0.56 -8.15 -0.41 7.47e-15 IgG glycosylation; CRC cis rs9322193 0.884 rs62439837 chr6:149991516 G/T cg05861140 chr6:150128134 PCMT1 -0.38 -5.87 -0.31 1.06e-8 Lung cancer; CRC cis rs7258465 1.000 rs2303695 chr19:18562624 C/T cg06462663 chr19:18546047 ISYNA1 0.46 6.9 0.36 2.62e-11 Breast cancer; CRC cis rs35883536 1.000 rs1610387 chr1:101123943 T/G cg14515779 chr1:101123966 NA -0.44 -8.65 -0.43 2.35e-16 Monocyte count; CRC cis rs10751667 0.621 rs4075990 chr11:976614 T/C cg23136738 chr11:925521 AP2A2 -0.42 -7.09 -0.36 8.19e-12 Alzheimer's disease (late onset); CRC cis rs9902453 0.753 rs3097118 chr17:27978466 C/T cg26525008 chr17:28256777 EFCAB5;SSH2 0.74 12.71 0.57 2.12e-30 Coffee consumption (cups per day); CRC cis rs6952808 1.000 rs4721121 chr7:1892565 A/G cg04267008 chr7:1944627 MAD1L1 -0.72 -10.64 -0.51 6.3e-23 Bipolar disorder and schizophrenia; CRC cis rs7618915 0.501 rs3774366 chr3:52641255 T/C cg11645453 chr3:52864694 ITIH4 0.36 6.49 0.34 3.24e-10 Bipolar disorder; CRC cis rs6429082 0.818 rs210037 chr1:235649501 A/G cg26050004 chr1:235667680 B3GALNT2 0.59 8.1 0.41 1.11e-14 Adiposity; CRC cis rs11583043 0.575 rs7528842 chr1:101583663 G/T cg16556008 chr1:101360663 SLC30A7;EXTL2 -0.43 -5.61 -0.3 4.41e-8 Ulcerative colitis;Inflammatory bowel disease; CRC cis rs2274471 0.645 rs73639261 chr9:5084215 G/A cg03390472 chr9:5043263 JAK2 -0.56 -6.0 -0.31 5.08e-9 Crohn's disease; CRC cis rs9913156 0.793 rs55682338 chr17:4582183 G/A cg19197139 chr17:4613644 ARRB2 0.83 10.95 0.52 5.52e-24 Lymphocyte counts; CRC cis rs875971 0.522 rs4718286 chr7:65292764 A/G cg18876405 chr7:65276391 NA 0.65 11.92 0.55 1.86e-27 Aortic root size; CRC cis rs911555 0.692 rs7140647 chr14:103893465 A/G cg12935359 chr14:103987150 CKB 0.6 9.6 0.47 2.08e-19 Intelligence (multi-trait analysis); CRC cis rs1707322 1.000 rs4298677 chr1:46306619 G/A cg03146154 chr1:46216737 IPP 0.5 6.92 0.36 2.34e-11 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs13108904 0.870 rs4974542 chr4:1250908 A/G cg19318889 chr4:1322082 MAEA 0.41 5.95 0.31 6.97e-9 Obesity-related traits; CRC cis rs1218582 0.774 rs4845681 chr1:154868055 G/T cg06221963 chr1:154839813 KCNN3 -0.75 -14.78 -0.63 2.8e-38 Prostate cancer; CRC cis rs6062302 0.522 rs3787107 chr20:62230576 G/A cg16989086 chr20:62203971 PRIC285 0.47 6.03 0.32 4.52e-9 Glioblastoma; CRC cis rs72634258 0.945 rs12730860 chr1:8132462 T/C cg00042356 chr1:8021962 PARK7 0.71 7.58 0.39 3.66e-13 Inflammatory bowel disease; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg06238426 chr17:71228473 C17orf80;FAM104A 0.42 6.23 0.32 1.44e-9 Intelligence (multi-trait analysis); CRC cis rs2257205 0.667 rs7208872 chr17:56777649 A/G cg25885038 chr17:56607967 SEPT4 -0.52 -5.69 -0.3 2.8e-8 Pancreatic cancer; CRC cis rs9325144 0.624 rs10783329 chr12:39113951 C/T cg26384229 chr12:38710491 ALG10B -0.5 -7.02 -0.36 1.26e-11 Morning vs. evening chronotype; CRC trans rs113835537 0.627 rs4630309 chr11:66333072 A/C cg05886006 chr1:161359784 NA 0.59 6.35 0.33 7.25e-10 Airway imaging phenotypes; CRC cis rs875971 0.929 rs12673810 chr7:65923853 T/A cg18912574 chr7:65842487 NCRNA00174 0.36 6.1 0.32 2.97e-9 Aortic root size; CRC cis rs34779708 1.000 rs12769189 chr10:35399668 A/G cg03585969 chr10:35415529 CREM 0.66 8.64 0.43 2.54e-16 Inflammatory bowel disease;Crohn's disease; CRC trans rs875971 0.660 rs2191268 chr7:66110224 C/T cg12845249 chr16:67876451 CENPT;THAP11 -0.39 -6.0 -0.31 5.07e-9 Aortic root size; CRC cis rs763014 0.966 rs4984675 chr16:670117 T/C cg00802000 chr16:706648 WDR90 -0.41 -5.95 -0.31 6.78e-9 Height; CRC cis rs2836974 0.863 rs8132333 chr21:40527900 A/G cg11890956 chr21:40555474 PSMG1 1.11 21.27 0.76 9.49e-64 Cognitive function; CRC trans rs7618501 0.538 rs9856572 chr3:50109073 A/T cg21659725 chr3:3221576 CRBN -0.53 -8.24 -0.41 4.02e-15 Intelligence (multi-trait analysis); CRC cis rs9916302 0.904 rs6503519 chr17:37706578 A/G cg15445000 chr17:37608096 MED1 0.42 9.34 0.46 1.45e-18 Glomerular filtration rate (creatinine); CRC trans rs1903068 1.000 rs4516787 chr4:56010165 C/T cg27327334 chr3:48484191 CCDC72 -0.35 -6.0 -0.31 5.31e-9 Endometriosis; CRC cis rs7172677 0.961 rs12102035 chr15:75418871 A/G cg14664628 chr15:75095509 CSK -0.47 -5.64 -0.3 3.69e-8 Systemic lupus erythematosus and Systemic sclerosis; CRC cis rs4713118 0.513 rs149955 chr6:28036225 G/C cg03623178 chr6:28175578 NA 0.77 11.23 0.53 5.67e-25 Parkinson's disease; CRC cis rs4731207 0.596 rs9969187 chr7:124661472 T/C cg23710748 chr7:124431027 NA -0.38 -6.07 -0.32 3.58e-9 Cutaneous malignant melanoma; CRC cis rs7113874 0.550 rs2044464 chr11:8559695 G/A cg17679104 chr11:8615758 STK33 -0.36 -5.96 -0.31 6.52e-9 Body mass index in physically active individuals;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs10760158 0.832 rs4837825 chr9:124015414 A/G cg14417974 chr9:124058376 GSN -0.34 -5.7 -0.3 2.62e-8 Pulse pressure; CRC cis rs9611565 0.592 rs12484467 chr22:41957610 T/C cg06634786 chr22:41940651 POLR3H -0.66 -7.49 -0.38 6.49e-13 Vitiligo; CRC cis rs9488822 0.676 rs6918059 chr6:116349041 C/T cg05304507 chr6:116381966 FRK 0.31 8.44 0.42 1.03e-15 Cholesterol, total;LDL cholesterol; CRC trans rs12478296 0.786 rs55876934 chr2:243033816 C/T cg18288967 chr1:45987694 PRDX1 0.69 7.65 0.39 2.25e-13 Obesity-related traits; CRC cis rs3768617 0.528 rs4651144 chr1:183097421 A/G ch.1.3577855R chr1:183094577 LAMC1 0.88 15.3 0.64 2.7e-40 Fuchs's corneal dystrophy; CRC cis rs60871478 1.000 rs62432899 chr7:826542 G/C cg13798912 chr7:905769 UNC84A 0.51 5.81 0.31 1.45e-8 Cerebrospinal P-tau181p levels; CRC cis rs951366 0.617 rs823075 chr1:205774897 C/T cg06877462 chr1:205807181 PM20D1 0.38 5.9 0.31 8.85e-9 Menarche (age at onset); CRC cis rs1707322 1.000 rs1707317 chr1:46510642 C/T cg03146154 chr1:46216737 IPP -0.59 -8.25 -0.41 3.93e-15 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC trans rs11026407 0.967 rs7127246 chr11:22060228 C/G cg25214684 chr1:39457099 AKIRIN1 -0.56 -6.1 -0.32 2.93e-9 Plasma thyroid-stimulating hormone levels; CRC cis rs11122272 0.735 rs2749714 chr1:231538634 G/C cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.59 -8.82 -0.44 6.97e-17 Hemoglobin concentration; CRC cis rs6504622 0.755 rs4074249 chr17:45149409 C/T cg16759221 chr17:45003025 GOSR2 0.43 6.69 0.35 9.65e-11 Orofacial clefts; CRC cis rs9926296 0.607 rs2079672 chr16:89884917 A/G cg03605463 chr16:89740564 NA 0.39 5.89 0.31 9.46e-9 Vitiligo; CRC cis rs10791323 0.604 rs2257010 chr11:133712348 G/A cg06766960 chr11:133703094 NA -0.36 -5.9 -0.31 8.85e-9 Childhood ear infection; CRC cis rs9768139 0.935 rs7809076 chr7:158118438 C/T cg06219351 chr7:158114137 PTPRN2 0.44 6.61 0.34 1.59e-10 Calcium levels; CRC cis rs2976388 1.000 rs2920295 chr8:143764937 A/G cg04969067 chr8:143858791 LYNX1 -0.37 -6.22 -0.32 1.55e-9 Urinary tract infection frequency; CRC cis rs1580019 0.961 rs4460271 chr7:32496503 T/C cg06627557 chr7:32535165 LSM5;AVL9 0.71 11.2 0.53 6.71e-25 Cognitive ability; CRC cis rs4930103 0.935 rs2071094 chr11:2021164 G/T cg06197492 chr11:2016605 H19 0.42 6.52 0.34 2.61e-10 DNA methylation (parent-of-origin);DNA methylation (variation); CRC cis rs2019137 0.560 rs7421852 chr2:113990261 G/A cg01577475 chr2:114033581 PAX8;LOC440839 -0.26 -6.48 -0.34 3.39e-10 Lymphocyte counts; CRC cis rs10760158 0.832 rs878691 chr9:124037607 C/T cg14417974 chr9:124058376 GSN -0.35 -5.89 -0.31 9.54e-9 Pulse pressure; CRC cis rs7666738 0.830 rs4441757 chr4:98927059 T/C cg05340658 chr4:99064831 C4orf37 0.6 9.35 0.46 1.41e-18 Colonoscopy-negative controls vs population controls; CRC trans rs1455244 0.700 rs7229302 chr18:11508904 G/T cg26207408 chr2:203500527 FAM117B 0.4 6.08 0.32 3.28e-9 Schizophrenia; CRC trans rs9467711 1.000 rs6903015 chr6:26322526 A/G cg15845792 chr6:28175446 NA 0.67 6.52 0.34 2.71e-10 Autism spectrum disorder or schizophrenia; CRC cis rs6088580 0.634 rs6088512 chr20:33095891 G/A cg24642439 chr20:33292090 TP53INP2 0.41 6.7 0.35 9.2e-11 Glomerular filtration rate (creatinine); CRC cis rs523522 0.962 rs4766966 chr12:120942911 G/C cg12219531 chr12:120966889 COQ5 0.62 8.39 0.42 1.41e-15 High light scatter reticulocyte count; CRC trans rs208520 0.909 rs9354411 chr6:67019930 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.83 9.86 0.48 2.82e-20 Exhaled nitric oxide output; CRC cis rs7927592 0.956 rs7102273 chr11:68385579 T/C cg16797656 chr11:68205561 LRP5 0.36 5.76 0.3 1.93e-8 Total body bone mineral density; CRC cis rs2882667 0.858 rs11959851 chr5:138421405 C/G cg09476006 chr5:138032270 NA 0.46 7.27 0.37 2.62e-12 Age-related hearing impairment (SNP x SNP interaction); CRC trans rs12713404 1.000 rs2419061 chr2:60016819 G/A cg03397442 chr10:128945079 DOCK1;FAM196A -0.46 -5.99 -0.31 5.65e-9 Resting heart rate; CRC cis rs1552244 0.554 rs3846167 chr3:9996426 T/C cg13047869 chr3:10149882 C3orf24 0.36 5.7 0.3 2.73e-8 Alzheimer's disease; CRC cis rs9467711 0.606 rs9379897 chr6:26601526 T/C cg16898833 chr6:26189333 HIST1H4D 0.89 7.39 0.38 1.2e-12 Autism spectrum disorder or schizophrenia; CRC trans rs875971 0.660 rs2191268 chr7:66110224 C/T cg23972301 chr1:117504011 PTGFRN 0.38 6.47 0.34 3.53e-10 Aortic root size; CRC cis rs9948 0.655 rs56913233 chr2:97405896 A/G cg20312557 chr2:97357134 FER1L5 -0.6 -5.61 -0.3 4.38e-8 Erectile dysfunction and prostate cancer treatment; CRC cis rs7208859 0.623 rs8082537 chr17:29015932 T/C cg01831904 chr17:28903510 LRRC37B2 -0.53 -5.89 -0.31 9.69e-9 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs780096 0.587 rs6760828 chr2:27579231 T/C cg12000995 chr2:27665139 KRTCAP3 -0.29 -5.93 -0.31 7.62e-9 Total body bone mineral density; CRC cis rs9303280 0.901 rs921650 chr17:38069076 G/A cg00129232 chr17:37814104 STARD3 0.46 7.28 0.37 2.45e-12 Self-reported allergy; CRC cis rs10504229 0.683 rs6999984 chr8:58115079 G/A cg22535103 chr8:58192502 C8orf71 -0.69 -9.28 -0.46 2.38e-18 Developmental language disorder (linguistic errors); CRC cis rs10992471 0.603 rs7033979 chr9:95223980 A/G cg14631576 chr9:95140430 CENPP -0.41 -7.32 -0.37 1.91e-12 Visceral adipose tissue/subcutaneous adipose tissue ratio; CRC cis rs6960043 0.818 rs10950546 chr7:15050391 C/T cg19272540 chr7:15055459 NA 0.23 5.9 0.31 8.81e-9 Type 2 diabetes; CRC trans rs2303319 0.582 rs72870248 chr2:162435849 G/A cg18122310 chr12:50236657 BCDIN3D -0.74 -6.06 -0.32 3.76e-9 Cognitive function; CRC cis rs910316 1.000 rs7145159 chr14:75583268 A/G cg08847533 chr14:75593920 NEK9 0.89 16.28 0.67 4.04e-44 Height; CRC cis rs2760061 0.626 rs2796057 chr1:228124414 G/C cg02753203 chr1:228287806 NA -0.67 -10.1 -0.49 4.48e-21 Diastolic blood pressure; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg16299428 chr3:30648098 TGFBR2 0.44 6.13 0.32 2.48e-9 Response to antipsychotic treatment; CRC cis rs1552244 0.572 rs57268864 chr3:10164233 C/A cg02579736 chr3:10068473 FANCD2;CIDECP 1.01 11.58 0.54 2.98e-26 Alzheimer's disease; CRC cis rs7385804 0.761 rs576236 chr7:100316975 C/T cg16850897 chr7:100343110 ZAN 0.45 6.67 0.34 1.11e-10 Iron status biomarkers;Mean corpuscular hemoglobin;Hematocrit;Iron status biomarkers (transferrin saturation);Red blood cell count;Iron status biomarkers (iron levels);Mean corpuscular volume;Hematological parameters; CRC cis rs4478858 0.684 rs12725881 chr1:31736123 C/T cg00250761 chr1:31883323 NA 0.37 7.19 0.37 4.43e-12 Alcohol dependence; CRC cis rs72945132 0.882 rs56770826 chr11:70128874 A/G cg14191688 chr11:70257035 CTTN 0.4 5.62 0.3 4.07e-8 Coronary artery disease; CRC cis rs62045849 0.557 rs6500534 chr16:89190313 C/T cg08015503 chr16:89190385 ACSF3 -0.93 -7.4 -0.38 1.18e-12 Red blood cell count; CRC cis rs11098499 1.000 rs7659194 chr4:120207147 T/G cg24375607 chr4:120327624 NA 0.47 7.22 0.37 3.65e-12 Corneal astigmatism; CRC cis rs3733585 0.781 rs13103690 chr4:9972778 T/G cg00071950 chr4:10020882 SLC2A9 -0.6 -11.01 -0.52 3.19e-24 Cleft plate (environmental tobacco smoke interaction); CRC cis rs8072100 0.902 rs12051716 chr17:45582395 G/A cg25173405 chr17:45401733 C17orf57 0.47 7.47 0.38 7.26e-13 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs28386778 0.701 rs2727337 chr17:61991966 G/A cg11494091 chr17:61959527 GH2 -0.77 -14.8 -0.63 2.33e-38 Prudent dietary pattern; CRC cis rs501120 0.657 rs583489 chr10:44738688 C/G cg09554077 chr10:44749378 NA 0.85 10.97 0.52 4.42e-24 Coronary artery disease;Coronary heart disease; CRC cis rs7208859 0.573 rs56031503 chr17:29075665 T/C cg01831904 chr17:28903510 LRRC37B2 -0.63 -6.46 -0.34 3.66e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs4478858 0.684 rs4949369 chr1:31723845 T/A cg00250761 chr1:31883323 NA -0.44 -8.52 -0.43 5.98e-16 Alcohol dependence; CRC cis rs9311676 0.656 rs59643048 chr3:58390248 A/G cg06643156 chr3:58380774 PXK 0.41 6.33 0.33 7.82e-10 Systemic lupus erythematosus; CRC cis rs6951245 0.744 rs10265736 chr7:1172465 C/T cg18402987 chr7:1209562 NA 0.68 7.88 0.4 4.72e-14 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs4654899 0.627 rs637990 chr1:21047616 A/G cg02927042 chr1:21476669 EIF4G3 0.43 6.54 0.34 2.34e-10 Superior frontal gyrus grey matter volume; CRC cis rs11155671 0.530 rs7756850 chr6:150212596 G/C cg07701084 chr6:150067640 NUP43 0.53 7.51 0.38 5.51e-13 Testicular germ cell tumor; CRC cis rs1707322 1.000 rs4606257 chr1:46307268 G/A cg06784218 chr1:46089804 CCDC17 0.6 10.83 0.51 1.46e-23 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs6903823 0.508 rs1233660 chr6:28260249 T/A cg06470822 chr6:28175283 NA 0.42 5.73 0.3 2.27e-8 Pulmonary function; CRC cis rs7772486 0.790 rs2265917 chr6:146212285 A/G cg13319975 chr6:146136371 FBXO30 -0.41 -6.2 -0.32 1.68e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs9303280 0.719 rs56750287 chr17:38062944 A/C cg20243544 chr17:37824526 PNMT 0.4 6.02 0.32 4.63e-9 Self-reported allergy; CRC cis rs2153535 0.563 rs7739249 chr6:8534590 C/G cg07606381 chr6:8435919 SLC35B3 0.65 10.32 0.49 8.34e-22 Motion sickness; CRC cis rs11098499 0.775 rs67281037 chr4:120281157 G/C cg24375607 chr4:120327624 NA 0.48 7.48 0.38 6.72e-13 Corneal astigmatism; CRC cis rs4363385 0.597 rs55667413 chr1:152976849 G/T cg25856811 chr1:152973957 SPRR3 -0.25 -6.76 -0.35 6.27e-11 Inflammatory skin disease; CRC cis rs250677 0.916 rs17109279 chr5:148416581 A/G cg23229984 chr5:148520753 ABLIM3 0.48 6.64 0.34 1.33e-10 Breast cancer; CRC cis rs1348850 0.632 rs1358328 chr2:178517532 G/A cg02961200 chr2:178257176 LOC100130691;AGPS 0.63 8.74 0.43 1.19e-16 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs7493 1.000 rs3735586 chr7:95035582 A/T cg04155289 chr7:94953770 PON1 -0.59 -7.54 -0.38 4.66e-13 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs34779708 0.931 rs55724039 chr10:35465397 A/G cg03585969 chr10:35415529 CREM 0.62 8.35 0.42 1.98e-15 Inflammatory bowel disease;Crohn's disease; CRC cis rs231513 0.954 rs231508 chr17:41967583 G/A cg26893861 chr17:41843967 DUSP3 -0.62 -6.35 -0.33 7.21e-10 Cognitive function; CRC cis rs11764590 0.671 rs56226325 chr7:2078981 C/T cg25834613 chr7:1915315 MAD1L1 -0.45 -6.34 -0.33 7.46e-10 Neuroticism; CRC cis rs9322193 0.639 rs4869756 chr6:150207496 G/A cg13206674 chr6:150067644 NUP43 0.47 5.75 0.3 2.09e-8 Lung cancer; CRC cis rs13031619 0.660 rs34855424 chr2:3702780 C/A cg00999904 chr2:3704751 ALLC -0.79 -9.75 -0.47 6.72e-20 Response to inhaled corticosteroid treatment in asthma (change in FEV1); CRC cis rs9910055 0.762 rs2526021 chr17:42213347 G/A cg19774624 chr17:42201019 HDAC5 -0.66 -9.77 -0.47 5.91e-20 Total body bone mineral density; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg25682936 chr1:38455768 SF3A3 0.46 5.96 0.31 6.39e-9 Thyroid stimulating hormone; CRC cis rs947211 0.898 rs10900524 chr1:205748309 G/A cg11965913 chr1:205819406 PM20D1 0.41 5.75 0.3 2.08e-8 Parkinson's disease; CRC cis rs2456568 0.802 rs10831136 chr11:93636860 T/C cg26875233 chr11:93583750 C11orf90 -0.32 -6.27 -0.33 1.14e-9 Response to serotonin reuptake inhibitors in major depressive disorder; CRC trans rs2303319 0.504 rs62189053 chr2:162624324 G/A cg22627826 chr19:1240265 ATP5D -0.72 -6.24 -0.33 1.37e-9 Cognitive function; CRC cis rs2996428 0.601 rs10909804 chr1:3770929 A/G cg13057898 chr1:3703894 LRRC47 -0.46 -6.23 -0.32 1.45e-9 Red cell distribution width; CRC cis rs6952809 0.532 rs2023969 chr7:2449980 T/C cg23289794 chr7:2394357 EIF3B -0.78 -9.19 -0.45 4.69e-18 Multiple sclerosis; CRC trans rs7395662 0.667 rs2865612 chr11:48780222 A/C cg21153622 chr11:89784906 NA 0.46 7.32 0.37 1.92e-12 HDL cholesterol; CRC cis rs868036 1.000 rs4776376 chr15:68093435 G/A cg05925327 chr15:68127851 NA -0.31 -6.01 -0.31 4.84e-9 Restless legs syndrome; CRC cis rs561341 1.000 rs2344312 chr17:30243583 G/T cg12193833 chr17:30244370 NA -0.58 -8.01 -0.4 1.96e-14 Hip circumference adjusted for BMI; CRC cis rs17818399 0.788 rs17818315 chr2:46818992 C/T cg06386533 chr2:46925753 SOCS5 0.45 5.74 0.3 2.09e-8 Height; CRC cis rs2404602 1.000 rs12441433 chr15:76816015 G/A cg22467129 chr15:76604101 ETFA -0.37 -6.16 -0.32 2.1e-9 Blood metabolite levels; CRC cis rs6076065 0.925 rs6083106 chr20:23368809 A/C cg11657817 chr20:23433608 CST11 0.37 5.92 0.31 8.09e-9 Facial morphology (factor 15, philtrum width); CRC cis rs3820068 0.734 rs72645830 chr1:15889910 A/G cg27534772 chr1:16042836 PLEKHM2 0.42 7.01 0.36 1.32e-11 Systolic blood pressure; CRC cis rs10883723 0.810 rs2296590 chr10:104262628 G/A cg11453585 chr10:104263688 ACTR1A;SUFU 0.92 17.58 0.7 2.89e-49 Allergic disease (asthma, hay fever or eczema); CRC cis rs9640161 0.789 rs10952250 chr7:150025966 T/C cg12556325 chr7:150026731 C7orf29;LRRC61 -0.4 -6.26 -0.33 1.19e-9 Blood protein levels;Circulating chemerin levels; CRC trans rs2710642 0.886 rs10153716 chr2:63007059 A/G cg05376469 chr2:102649931 NA 0.38 6.21 0.32 1.63e-9 LDL cholesterol levels;LDL cholesterol; CRC cis rs853679 0.517 rs9380061 chr6:28132803 T/C cg23161317 chr6:28129485 ZNF389 0.53 6.43 0.33 4.52e-10 Depression; CRC cis rs4665630 0.522 rs75866363 chr2:24046426 G/A cg08063864 chr2:24346004 PFN4;LOC375190 0.94 7.56 0.38 4.03e-13 Hypertension; CRC trans rs12478296 1.000 rs113129906 chr2:243004253 C/T cg18288967 chr1:45987694 PRDX1 0.66 6.64 0.34 1.26e-10 Obesity-related traits; CRC cis rs9549367 0.789 rs9549708 chr13:113891887 A/G cg00898013 chr13:113819073 PROZ -0.45 -6.32 -0.33 8.43e-10 Platelet distribution width; CRC cis rs873946 0.648 rs35417213 chr10:134553749 A/G cg27286337 chr10:134555280 INPP5A 0.83 10.35 0.5 6.32e-22 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CRC cis rs3018066 0.831 rs10049933 chr4:107078887 T/C cg01869342 chr4:106983673 TBCK 0.37 5.74 0.3 2.15e-8 Cancer; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg03346041 chr8:68255952 ARFGEF1 0.44 6.15 0.32 2.22e-9 Thyroid stimulating hormone; CRC cis rs4909189 1.000 rs12698214 chr7:158136204 T/G cg25566285 chr7:158114605 PTPRN2 0.42 5.78 0.3 1.77e-8 Response to amphetamines; CRC trans rs10842750 1.000 rs10842750 chr12:26690565 G/T cg01860201 chr4:75720019 BTC 0.51 6.23 0.32 1.44e-9 Kashin-Beck disease; CRC cis rs2745959 0.527 rs2473653 chr1:208101656 C/T cg15031826 chr1:208136952 NA 0.36 5.65 0.3 3.52e-8 Resting heart rate; CRC trans rs35110281 0.748 rs1584918 chr21:45042419 C/T cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.5 8.28 0.42 3.2e-15 Mean corpuscular volume; CRC cis rs11608355 0.515 rs12826754 chr12:109923244 A/G cg05360138 chr12:110035743 NA 0.78 8.76 0.43 1.07e-16 Neuroticism; CRC cis rs2108225 1.000 rs989960 chr7:107445727 C/T cg18560240 chr7:107437656 SLC26A3 -0.55 -8.38 -0.42 1.53e-15 Ulcerative colitis; CRC cis rs12908161 1.000 rs62019464 chr15:85294469 T/A cg17507749 chr15:85114479 UBE2QP1 0.62 8.97 0.44 2.36e-17 Schizophrenia; CRC cis rs1572438 1.000 rs1572438 chr6:858970 A/G cg13447295 chr6:887704 NA 0.44 6.27 0.33 1.12e-9 Aging; CRC cis rs67311347 1.000 rs2305522 chr3:40429358 A/G cg24209194 chr3:40518798 ZNF619 0.42 6.44 0.33 4.36e-10 Renal cell carcinoma; CRC cis rs12134245 0.874 rs17501937 chr1:92021705 C/T cg21854759 chr1:92012499 NA 0.39 6.0 0.31 5.28e-9 Breast cancer; CRC cis rs11628318 0.614 rs10140498 chr14:103154191 A/G cg23071808 chr14:103021642 NA 0.53 6.33 0.33 7.82e-10 Platelet count; CRC cis rs546131 0.890 rs496558 chr11:34826425 C/T cg11058730 chr11:34937778 PDHX;APIP 0.46 6.63 0.34 1.39e-10 Lung disease severity in cystic fibrosis; CRC cis rs289828 0.868 rs3771886 chr2:152138522 T/C cg06191203 chr2:152266755 RIF1 -0.4 -5.74 -0.3 2.11e-8 Blood protein levels; CRC cis rs738322 0.967 rs133018 chr22:38572761 G/A cg17652424 chr22:38574118 PLA2G6 -0.22 -6.86 -0.35 3.41e-11 Cutaneous nevi; CRC cis rs11030122 0.687 rs10835521 chr11:4056004 A/T cg18678763 chr11:4115507 RRM1 -0.48 -7.67 -0.39 1.97e-13 Mean platelet volume;Platelet distribution width; CRC cis rs9894429 0.966 rs10871499 chr17:79589006 G/A cg18240062 chr17:79603768 NPLOC4 0.56 9.34 0.46 1.54e-18 Eye color traits; CRC cis rs1552244 0.872 rs6792951 chr3:10119603 C/A cg00166722 chr3:10149974 C3orf24 0.66 9.03 0.45 1.5e-17 Alzheimer's disease; CRC trans rs12478296 1.000 rs12478296 chr2:243048760 A/G cg18288967 chr1:45987694 PRDX1 -0.68 -7.74 -0.39 1.27e-13 Obesity-related traits; CRC cis rs1218582 0.710 rs4845685 chr1:154878300 C/A cg24250549 chr1:154909240 PMVK 0.65 11.29 0.53 3.2e-25 Prostate cancer; CRC cis rs739401 0.572 rs384490 chr11:3078885 A/C cg25174290 chr11:3078921 CARS 0.51 7.98 0.4 2.44e-14 Longevity; CRC cis rs13108904 0.870 rs12642797 chr4:1245990 G/A cg20887711 chr4:1340912 KIAA1530 0.41 5.85 0.31 1.19e-8 Obesity-related traits; CRC cis rs889312 0.500 rs11960484 chr5:56109154 C/T cg18230493 chr5:56204884 C5orf35 0.39 5.86 0.31 1.11e-8 Breast cancer;Breast cancer (early onset); CRC trans rs8005150 0.737 rs8003806 chr14:88463388 C/A cg25527770 chr19:1444892 NA -0.55 -6.04 -0.32 4.12e-9 Hepatitis B; CRC cis rs7113874 0.524 rs10769922 chr11:8621752 G/A cg02811074 chr11:8615871 STK33 0.33 5.88 0.31 9.85e-9 Body mass index in physically active individuals;Body mass index (joint analysis main effects and physical activity interaction); CRC trans rs11764590 0.724 rs55789728 chr7:2107649 A/G cg11693508 chr17:37793320 STARD3 0.51 6.57 0.34 1.93e-10 Neuroticism; CRC cis rs3857067 1.000 rs1509943 chr4:95013366 A/G cg11021082 chr4:95130006 SMARCAD1 -0.4 -6.05 -0.32 3.9e-9 QT interval; CRC cis rs1967309 0.625 rs730242 chr16:4070433 C/T cg00061520 chr16:4070371 ADCY9 0.36 6.01 0.31 4.87e-9 Response to Dalcetrapib treatment in acute coronary syndrome; CRC cis rs4665809 0.590 rs4665318 chr2:26424517 C/T cg25036284 chr2:26402008 FAM59B 0.62 7.78 0.39 9.59e-14 Gut microbiome composition (summer); CRC cis rs6460942 0.591 rs62448726 chr7:12330881 A/G cg06484146 chr7:12443880 VWDE -0.64 -6.83 -0.35 4.2e-11 Coronary artery disease; CRC cis rs2836974 0.799 rs13047550 chr21:40515495 T/C cg06238570 chr21:40685208 BRWD1 0.7 9.31 0.46 1.85e-18 Cognitive function; CRC cis rs2257205 0.667 rs6503881 chr17:56911251 C/T cg25885038 chr17:56607967 SEPT4 -0.53 -5.82 -0.31 1.43e-8 Pancreatic cancer; CRC cis rs12477438 0.520 rs4588238 chr2:99749350 T/C cg26064155 chr2:99771622 LIPT1;TSGA10 0.87 15.71 0.65 6.73e-42 Chronic sinus infection; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg26918957 chr8:22926800 TNFRSF10B 0.39 6.03 0.32 4.34e-9 Liver disease severity in Alagille syndrome; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg01735101 chr19:19774554 ATP13A1 0.45 6.28 0.33 1.05e-9 Response to antipsychotic treatment; CRC cis rs853679 0.517 rs9380056 chr6:28104476 C/T cg18032046 chr6:28092343 ZSCAN16 -0.52 -6.08 -0.32 3.3e-9 Depression; CRC cis rs2019137 0.936 rs2241978 chr2:113954006 A/G cg07772999 chr2:113993052 PAX8;LOC440839;LOC654433 -0.46 -6.5 -0.34 2.97e-10 Lymphocyte counts; CRC cis rs992157 0.835 rs2045434 chr2:219144498 A/G cg00012203 chr2:219082015 ARPC2 -0.47 -7.11 -0.37 7.1e-12 Colorectal cancer; CRC cis rs6952808 0.609 rs4721185 chr7:1951109 T/C cg21782813 chr7:2030301 MAD1L1 0.4 7.38 0.38 1.28e-12 Bipolar disorder and schizophrenia; CRC cis rs4819052 0.766 rs4819035 chr21:46645715 A/C cg19498844 chr21:46707878 POFUT2;LOC642852 0.69 8.57 0.43 4.19e-16 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs2795502 1.000 rs3121323 chr10:43377166 A/G cg27426351 chr10:43362370 NA -0.63 -7.54 -0.38 4.75e-13 Blood protein levels; CRC cis rs7659604 0.539 rs7699776 chr4:122753885 A/G cg06713675 chr4:122721982 EXOSC9 -0.51 -8.32 -0.42 2.31e-15 Type 2 diabetes; CRC cis rs990171 0.955 rs4241210 chr2:103078740 G/A cg03938978 chr2:103052716 IL18RAP 0.46 5.88 0.31 1e-8 Lymphocyte counts; CRC trans rs1005277 0.505 rs10827835 chr10:38150709 G/A cg27523141 chr10:43048294 ZNF37B -0.45 -6.52 -0.34 2.65e-10 Extrinsic epigenetic age acceleration; CRC cis rs763121 0.853 rs2294296 chr22:39053049 T/C cg06544989 chr22:39130855 UNC84B 0.44 6.79 0.35 5.41e-11 Menopause (age at onset); CRC cis rs2075371 1.000 rs2598297 chr7:133993001 T/G cg20476274 chr7:133979776 SLC35B4 0.82 14.76 0.63 3.49e-38 Mean platelet volume; CRC cis rs9660180 0.836 rs72634845 chr1:1704899 G/A cg23982607 chr1:1823379 GNB1 -0.85 -14.86 -0.63 1.48e-38 Body mass index; CRC trans rs7937682 0.824 rs11213962 chr11:111506027 G/A cg18187862 chr3:45730750 SACM1L 0.48 6.88 0.35 3.04e-11 Primary sclerosing cholangitis; CRC cis rs3008870 0.583 rs11208978 chr1:67442210 C/T cg11518657 chr1:67396239 MIER1 -0.57 -6.07 -0.32 3.47e-9 Lymphocyte percentage of white cells; CRC cis rs2976388 0.632 rs2585139 chr8:143808175 C/G cg15511327 chr8:143859410 LYNX1 0.41 7.2 0.37 4.06e-12 Urinary tract infection frequency; CRC cis rs13256369 0.901 rs4841015 chr8:8567140 C/G cg18904891 chr8:8559673 CLDN23 0.53 7.19 0.37 4.26e-12 Obesity-related traits; CRC cis rs4819052 0.851 rs2838848 chr21:46671017 A/G cg02159808 chr21:46707872 POFUT2;LOC642852 0.49 6.54 0.34 2.4e-10 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs738322 0.967 rs132985 chr22:38563471 C/T cg25457927 chr22:38595422 NA -0.34 -6.95 -0.36 1.91e-11 Cutaneous nevi; CRC cis rs4713118 0.826 rs2893929 chr6:27738732 A/T cg02683197 chr6:28174875 NA 0.68 7.33 0.37 1.81e-12 Parkinson's disease; CRC cis rs11608355 1.000 rs10850134 chr12:109861454 G/C cg19025524 chr12:109796872 NA -0.46 -6.5 -0.34 2.96e-10 Neuroticism; CRC cis rs6582630 0.599 rs7967598 chr12:38540760 C/T cg26384229 chr12:38710491 ALG10B -0.52 -7.43 -0.38 9.75e-13 Drug-induced liver injury (flucloxacillin); CRC cis rs12999616 0.602 rs17489259 chr2:98392302 G/A cg26665480 chr2:98280029 ACTR1B 0.55 6.3 0.33 9.69e-10 Colorectal cancer; CRC cis rs2811415 0.597 rs10934843 chr3:127749605 C/T cg13719885 chr3:127795394 NA -0.38 -5.78 -0.3 1.71e-8 Lung function (FEV1/FVC); CRC cis rs34172651 0.876 rs1862451 chr16:24803620 A/G cg06028605 chr16:24865363 SLC5A11 0.43 7.77 0.39 1e-13 Intelligence (multi-trait analysis); CRC trans rs12599106 0.624 rs2173885 chr16:34992749 G/A cg01171360 chr6:293285 DUSP22 -0.56 -7.93 -0.4 3.51e-14 Menopause (age at onset); CRC cis rs28386778 0.897 rs2044125 chr17:61863184 A/C cg06873352 chr17:61820015 STRADA -0.77 -14.7 -0.63 6.04e-38 Prudent dietary pattern; CRC cis rs6582630 0.622 rs11831595 chr12:38511489 C/A cg26384229 chr12:38710491 ALG10B -0.52 -7.54 -0.38 4.68e-13 Drug-induced liver injury (flucloxacillin); CRC cis rs4481887 0.708 rs6587463 chr1:248544452 G/C cg00666640 chr1:248458726 OR2T12 0.4 7.28 0.37 2.49e-12 Common traits (Other); CRC cis rs812925 0.502 rs778150 chr2:61608372 C/T cg10580144 chr2:61372316 C2orf74 -0.33 -7.34 -0.38 1.66e-12 Immature fraction of reticulocytes; CRC cis rs9469890 0.604 rs11756280 chr6:34503439 T/C cg17674042 chr6:34482479 PACSIN1 -0.63 -7.45 -0.38 8.35e-13 Pubertal anthropometrics;Coronary artery disease; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg21570168 chr14:102226945 PPP2R5C -0.49 -7.9 -0.4 4.14e-14 Myopia (pathological); CRC trans rs11039798 0.512 rs11040205 chr11:49007360 G/C cg15704280 chr7:45808275 SEPT13 0.65 6.56 0.34 2.11e-10 Axial length; CRC cis rs7727544 0.582 rs3749756 chr5:131534499 C/T cg02033258 chr5:131593261 PDLIM4 0.32 5.84 0.31 1.24e-8 Blood metabolite levels; CRC cis rs67311347 1.000 rs4973989 chr3:40451543 C/T cg09455208 chr3:40491958 NA 0.49 9.24 0.45 3.19e-18 Renal cell carcinoma; CRC cis rs929354 0.772 rs2051876 chr7:157009037 A/G cg17757837 chr7:157058334 UBE3C -0.72 -12.28 -0.56 8.95e-29 Body mass index; CRC cis rs3736594 0.513 rs62138964 chr2:27814438 C/T cg27432699 chr2:27873401 GPN1 0.65 8.29 0.42 2.95e-15 Fasting blood glucose;Fasting blood glucose (BMI interaction); CRC cis rs9640161 0.789 rs1464753 chr7:150021350 G/C cg12556325 chr7:150026731 C7orf29;LRRC61 -0.43 -6.41 -0.33 4.9e-10 Blood protein levels;Circulating chemerin levels; CRC cis rs3764400 0.508 rs72823528 chr17:46098944 C/T cg10706073 chr17:46328419 SKAP1 -0.65 -6.85 -0.35 3.56e-11 Body mass index; CRC cis rs992157 0.796 rs55680399 chr2:219160621 T/C cg13835894 chr2:219148914 PNKD;TMBIM1 0.31 5.92 0.31 7.97e-9 Colorectal cancer; CRC cis rs6951245 0.872 rs76713558 chr7:1095866 A/G cg26224354 chr7:1096374 C7orf50;GPR146 -0.93 -12.11 -0.56 3.59e-28 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs7811142 0.887 rs111972532 chr7:100069088 T/C cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.16 16.52 0.67 4.74e-45 Platelet count; CRC cis rs703842 1.000 rs11172335 chr12:58175201 C/T cg00677455 chr12:58241039 CTDSP2 0.64 8.65 0.43 2.31e-16 Multiple sclerosis; CRC trans rs2727020 0.619 rs1164665 chr11:49295630 T/C cg03929089 chr4:120376271 NA 0.62 8.2 0.41 5.52e-15 Coronary artery disease; CRC cis rs41005 0.967 rs193927 chr2:8108055 G/A cg03155496 chr2:8117019 LOC339788 0.42 7.46 0.38 7.83e-13 Response to anti-TNF therapy in rheumatoid arthritis; CRC cis rs6860806 0.507 rs273915 chr5:131660119 G/C cg18758796 chr5:131593413 PDLIM4 0.39 6.35 0.33 7.23e-10 Breast cancer; CRC trans rs2303319 0.504 rs58622044 chr2:162596287 A/G cg12500891 chr11:57225987 NA -0.66 -6.1 -0.32 2.98e-9 Cognitive function; CRC cis rs12048904 0.512 rs932798 chr1:101249355 G/C cg16556008 chr1:101360663 SLC30A7;EXTL2 -0.82 -12.98 -0.58 2.1e-31 Multiple sclerosis; CRC cis rs9311474 0.713 rs352168 chr3:52237970 C/T cg18099408 chr3:52552593 STAB1 -0.36 -5.85 -0.31 1.2e-8 Electroencephalogram traits; CRC cis rs2404602 0.552 rs11630185 chr15:76959783 A/T cg23625390 chr15:77176239 SCAPER -0.77 -10.21 -0.49 1.87e-21 Blood metabolite levels; CRC cis rs7208859 0.623 rs57486336 chr17:29085731 G/T cg13385521 chr17:29058706 SUZ12P 0.73 8.4 0.42 1.39e-15 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs939584 1.000 rs7571970 chr2:646849 T/C cg03610516 chr2:642275 NA 0.42 5.88 0.31 9.94e-9 Body mass index; CRC cis rs9560113 1.000 rs11620313 chr13:112179363 G/A cg10483660 chr13:112241077 NA 0.36 5.81 0.3 1.49e-8 Menarche (age at onset); CRC cis rs9611519 0.589 rs8138917 chr22:41412425 T/C cg03806693 chr22:41940476 POLR3H -0.41 -5.75 -0.3 2.07e-8 Neuroticism; CRC cis rs4713118 0.513 rs156739 chr6:28013410 C/A cg18032046 chr6:28092343 ZSCAN16 -0.42 -5.75 -0.3 2.01e-8 Parkinson's disease; CRC cis rs6564851 0.506 rs56053403 chr16:81259025 T/C cg05274606 chr16:81253692 PKD1L2 -0.38 -6.28 -0.33 1.05e-9 Carotenoid and tocopherol levels; CRC cis rs12545109 0.842 rs2670050 chr8:57402914 T/G cg09654669 chr8:57350985 NA -0.38 -5.62 -0.3 4.05e-8 Obesity-related traits; CRC cis rs10504229 0.728 rs72650867 chr8:58154912 C/T cg02725872 chr8:58115012 NA -0.57 -9.07 -0.45 1.09e-17 Developmental language disorder (linguistic errors); CRC cis rs9611565 0.512 rs5758436 chr22:42124265 C/T cg03806693 chr22:41940476 POLR3H 1.06 13.33 0.59 1.06e-32 Vitiligo; CRC trans rs72956618 0.715 rs72933222 chr2:207319653 C/T cg20754261 chr2:468330 NA -0.61 -6.02 -0.31 4.57e-9 Tonsillectomy; CRC trans rs1005277 0.579 rs1780133 chr10:38499509 T/C cg27523141 chr10:43048294 ZNF37B 0.47 6.96 0.36 1.88e-11 Extrinsic epigenetic age acceleration; CRC cis rs2019137 0.936 rs731834 chr2:113957198 A/C cg21610815 chr2:113994035 PAX8;LOC654433;LOC440839 -0.45 -6.28 -0.33 1.07e-9 Lymphocyte counts; CRC trans rs747782 0.585 rs1316604 chr11:48279796 G/A cg02254774 chr11:50257496 LOC441601 0.57 6.03 0.32 4.46e-9 Intraocular pressure; CRC cis rs360798 0.512 rs2430388 chr2:63106784 T/C cg17519650 chr2:63277830 OTX1 0.45 6.42 0.33 4.68e-10 Coronary artery disease; CRC cis rs2051211 1.000 rs17037804 chr3:38559215 A/G cg01465620 chr3:38496096 LOC100128640;ACVR2B -0.48 -6.44 -0.33 4.16e-10 QRS duration; CRC cis rs877282 0.891 rs11253355 chr10:768367 C/G cg06581033 chr10:766294 NA -0.52 -5.77 -0.3 1.84e-8 Uric acid levels; CRC cis rs4285028 0.948 rs34543553 chr3:121675637 C/T cg11130432 chr3:121712080 ILDR1 -0.52 -6.75 -0.35 6.81e-11 Multiple sclerosis; CRC trans rs57221529 0.825 rs7443550 chr5:578404 G/T cg11887960 chr12:57824829 NA 0.62 6.76 0.35 6.26e-11 Lung disease severity in cystic fibrosis; CRC cis rs10540 1.000 rs12419766 chr11:503710 C/T cg15790184 chr11:494944 RNH1 0.6 6.17 0.32 1.95e-9 Body mass index; CRC cis rs17270561 0.609 rs2000350 chr6:25763154 T/C cg17691542 chr6:26056736 HIST1H1C 0.64 8.14 0.41 8.02e-15 Iron status biomarkers; CRC cis rs2836974 0.831 rs34592564 chr21:40516288 G/C cg17971929 chr21:40555470 PSMG1 0.71 9.56 0.47 2.97e-19 Cognitive function; CRC cis rs28374715 0.681 rs7162231 chr15:41591859 G/A cg18705301 chr15:41695430 NDUFAF1 -1.1 -18.12 -0.71 2.23e-51 Ulcerative colitis; CRC cis rs6952808 0.792 rs34269264 chr7:1948712 C/T cg00106254 chr7:1943704 MAD1L1 -0.52 -7.62 -0.39 2.82e-13 Bipolar disorder and schizophrenia; CRC cis rs9611565 0.694 rs202656 chr22:41842203 T/A cg03806693 chr22:41940476 POLR3H 1.1 13.33 0.59 1.08e-32 Vitiligo; CRC cis rs10489202 0.608 rs6657019 chr1:168079669 T/C cg24449463 chr1:168025552 DCAF6 -0.51 -7.09 -0.36 8.3e-12 Schizophrenia; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg14524403 chr9:136325208 C9orf7 0.43 6.27 0.33 1.12e-9 Intelligence (multi-trait analysis); CRC cis rs1971762 0.527 rs7311902 chr12:54015236 A/G cg06632207 chr12:54070931 ATP5G2 0.45 7.67 0.39 1.98e-13 Height; CRC cis rs6546550 0.869 rs6712827 chr2:70156540 C/G cg02498382 chr2:70120550 SNRNP27 -0.56 -9.55 -0.47 3.18e-19 Prevalent atrial fibrillation; CRC cis rs7487637 0.529 rs56389811 chr12:48205358 C/T cg14736327 chr12:48174669 SLC48A1 -0.63 -7.86 -0.4 5.62e-14 Mononucleosis; CRC trans rs1005277 0.579 rs1780146 chr10:38517874 C/A cg11292332 chr7:45801988 SEPT13 -0.38 -6.81 -0.35 4.75e-11 Extrinsic epigenetic age acceleration; CRC cis rs9462846 0.811 rs6938994 chr6:42879326 C/T cg21280719 chr6:42927975 GNMT -0.34 -6.51 -0.34 2.75e-10 Blood protein levels; CRC cis rs1862618 0.671 rs2591966 chr5:56233688 T/G cg12311346 chr5:56204834 C5orf35 0.6 9.18 0.45 4.91e-18 Initial pursuit acceleration; CRC cis rs11098499 0.754 rs878372 chr4:120238780 A/C cg24375607 chr4:120327624 NA 0.48 7.64 0.39 2.32e-13 Corneal astigmatism; CRC cis rs990171 0.908 rs731628 chr2:103082571 C/T cg03938978 chr2:103052716 IL18RAP 0.46 5.88 0.31 1e-8 Lymphocyte counts; CRC cis rs17384381 0.834 rs12130380 chr1:85901309 T/C cg16011679 chr1:85725395 C1orf52 0.58 6.3 0.33 9.27e-10 Lobe attachment (rater-scored or self-reported); CRC cis rs12760731 0.565 rs12049568 chr1:178154345 A/G cg00404053 chr1:178313656 RASAL2 1.02 10.74 0.51 2.85e-23 Obesity-related traits; CRC trans rs6076960 0.684 rs6038408 chr20:6268983 A/C cg24759859 chr6:86352639 SYNCRIP 0.49 6.7 0.35 9.16e-11 Smooth-surface caries; CRC trans rs2797160 1.000 rs1739373 chr6:126011509 A/G cg05039488 chr6:79577232 IRAK1BP1 0.49 7.18 0.37 4.57e-12 Endometrial cancer; CRC cis rs11252926 0.589 rs12359901 chr10:475068 A/G cg18196295 chr10:418757 DIP2C -0.55 -8.3 -0.42 2.82e-15 Psychosis in Alzheimer's disease; CRC cis rs10876993 0.928 rs1689592 chr12:58057773 C/T cg15848620 chr12:58087721 OS9 -0.65 -9.27 -0.45 2.57e-18 Celiac disease or Rheumatoid arthritis; CRC cis rs10504229 0.683 rs11774697 chr8:58133119 G/A cg22535103 chr8:58192502 C8orf71 -0.75 -8.49 -0.42 7.41e-16 Developmental language disorder (linguistic errors); CRC cis rs9992667 0.911 rs28360925 chr4:38617297 A/T cg19726192 chr4:38663646 FLJ13197 -0.58 -7.49 -0.38 6.58e-13 Eosinophil percentage of granulocytes; CRC cis rs12900413 0.687 rs7176948 chr15:90315707 A/C cg24249390 chr15:90295951 MESP1 -0.59 -9.58 -0.47 2.51e-19 Coronary artery aneurysm in Kawasaki disease; CRC cis rs7119 0.667 rs1058129 chr15:77905661 A/G cg27398640 chr15:77910606 LINGO1 0.46 8.45 0.42 9.61e-16 Type 2 diabetes; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg06524757 chr13:72441523 DACH1 0.38 6.47 0.34 3.62e-10 Liver disease severity in Alagille syndrome; CRC cis rs5760092 0.755 rs915589 chr22:24261004 C/T cg18538332 chr22:24372958 LOC391322 0.66 7.22 0.37 3.64e-12 Urinary 1,3-butadiene metabolite levels in smokers; CRC cis rs12249377 0.519 rs10785972 chr10:92593800 C/T cg14313238 chr10:92632228 RPP30 0.47 6.49 0.34 3.22e-10 White matter microstructure (global fractional anisotropy); CRC trans rs2797160 0.967 rs80303782 chr6:126004193 C/T cg05039488 chr6:79577232 IRAK1BP1 -0.49 -7.1 -0.36 7.91e-12 Endometrial cancer; CRC cis rs4332037 0.624 rs11766944 chr7:1888051 G/A cg21155852 chr7:2048760 MAD1L1 -0.42 -6.05 -0.32 4.03e-9 Bipolar disorder; CRC cis rs860295 0.665 rs12079134 chr1:155466784 C/G cg02153340 chr1:155202674 NA -0.52 -6.49 -0.34 3.08e-10 Body mass index; CRC cis rs853679 0.527 rs707907 chr6:28291240 A/G cg03623178 chr6:28175578 NA 0.48 6.58 0.34 1.87e-10 Depression; CRC cis rs896854 0.654 rs13278601 chr8:95972974 G/C cg09323728 chr8:95962352 TP53INP1 -0.45 -7.43 -0.38 9.7e-13 Type 2 diabetes; CRC trans rs6102059 0.748 rs6129648 chr20:39231118 A/G cg05435295 chr11:125703230 PATE4 0.36 6.78 0.35 5.45e-11 LDL cholesterol; CRC cis rs2732480 0.557 rs923397 chr12:48720392 G/A cg04545296 chr12:48745243 ZNF641 0.33 5.64 0.3 3.63e-8 Hemoglobin concentration;Red blood cell count;Hematocrit; CRC cis rs72717009 0.825 rs9427399 chr1:161476533 T/C cg23840854 chr1:161414152 NA -0.66 -7.93 -0.4 3.41e-14 Rheumatoid arthritis; CRC cis rs2645694 0.626 rs12502590 chr4:77823642 G/A cg06046430 chr4:77819534 ANKRD56 0.41 5.65 0.3 3.53e-8 Emphysema distribution in smoking; CRC trans rs7395662 0.534 rs12418219 chr11:48988091 G/T cg03929089 chr4:120376271 NA -0.49 -7.01 -0.36 1.36e-11 HDL cholesterol; CRC cis rs9911578 0.967 rs4132925 chr17:56938016 C/G cg05425664 chr17:57184151 TRIM37 0.52 8.11 0.41 9.98e-15 Intelligence (multi-trait analysis); CRC cis rs354225 0.626 rs7608414 chr2:54844995 G/A cg26097391 chr2:54893211 SPTBN1 0.38 5.67 0.3 3.2e-8 Schizophrenia; CRC cis rs929596 0.501 rs4530361 chr2:234590041 A/G cg07512295 chr2:234599026 UGT1A6;UGT1A10;UGT1A9;UGT1A7;UGT1A8 0.38 5.85 0.31 1.2e-8 Total bilirubin levels in HIV-1 infection; CRC cis rs898097 1.000 rs898097 chr17:80904310 C/T cg19046167 chr17:80928561 B3GNTL1 0.4 6.39 0.33 5.54e-10 Breast cancer; CRC cis rs7191439 0.858 rs6500489 chr16:88772046 T/C cg02389323 chr16:88786976 FAM38A 1.11 9.14 0.45 6.46e-18 Plateletcrit; CRC cis rs3806843 0.966 rs2563260 chr5:140137867 C/A cg19875535 chr5:140030758 IK -0.6 -9.86 -0.48 2.83e-20 Depressive symptoms (multi-trait analysis); CRC cis rs6459788 0.720 rs6965466 chr7:157250749 G/T cg03453431 chr7:157225567 NA -0.53 -8.42 -0.42 1.14e-15 Epstein-Barr virus copy number in lymphoblastoid cell lines; CRC cis rs748404 0.697 rs524547 chr15:43551023 C/T cg02155558 chr15:43621948 ADAL;LCMT2 0.41 6.23 0.32 1.4e-9 Lung cancer; CRC cis rs7786808 0.525 rs10253961 chr7:158194858 G/A cg09998033 chr7:158218633 PTPRN2 0.49 6.89 0.36 2.87e-11 Obesity-related traits; CRC cis rs4664293 0.867 rs7565297 chr2:160572519 G/A cg08347373 chr2:160653686 CD302 -0.47 -7.45 -0.38 8.04e-13 Monocyte percentage of white cells; CRC cis rs10504229 0.679 rs11783444 chr8:58131267 A/G cg22535103 chr8:58192502 C8orf71 -0.7 -9.34 -0.46 1.47e-18 Developmental language disorder (linguistic errors); CRC cis rs2197308 0.740 rs10880619 chr12:37922720 T/C cg26384229 chr12:38710491 ALG10B 0.67 8.88 0.44 4.54e-17 Morning vs. evening chronotype; CRC cis rs910316 0.763 rs175435 chr14:75612025 A/G cg08847533 chr14:75593920 NEK9 0.81 14.03 0.61 2.18e-35 Height; CRC cis rs4665809 0.590 rs3806514 chr2:26466772 C/T cg25036284 chr2:26402008 FAM59B 0.65 8.57 0.43 4.22e-16 Gut microbiome composition (summer); CRC trans rs1814175 0.615 rs10839378 chr11:49806943 C/T cg21153622 chr11:89784906 NA -0.39 -6.13 -0.32 2.56e-9 Height; CRC cis rs875971 0.825 rs1129531 chr7:65619104 C/T cg18876405 chr7:65276391 NA -0.52 -8.57 -0.43 4.14e-16 Aortic root size; CRC trans rs79464052 0.571 rs10491312 chr5:140940596 A/C cg05255351 chr5:1503979 LPCAT1 -0.45 -6.07 -0.32 3.6e-9 Diffuse large B cell lymphoma; CRC cis rs4713118 0.955 rs34752872 chr6:27683244 A/T cg06470822 chr6:28175283 NA 0.68 8.91 0.44 3.6e-17 Parkinson's disease; CRC cis rs7909074 1.000 rs12777258 chr10:45394961 A/G cg04218760 chr10:45406644 TMEM72 0.37 10.36 0.5 5.82e-22 Mean corpuscular volume; CRC trans rs1814175 0.817 rs11040474 chr11:49708441 G/A cg11707556 chr5:10655725 ANKRD33B -0.43 -8.1 -0.41 1.1e-14 Height; CRC cis rs801193 1.000 rs62466793 chr7:66191517 G/A cg05627663 chr7:65219948 SNORA22;CCT6P1 0.41 5.94 0.31 7.33e-9 Aortic root size; CRC cis rs72615157 0.612 rs7786505 chr7:99817585 G/T cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.5 5.95 0.31 6.72e-9 Lung function (FEV1/FVC); CRC cis rs3820928 0.934 rs16822890 chr2:227761477 G/A cg11843606 chr2:227700838 RHBDD1 -0.4 -5.7 -0.3 2.67e-8 Pulmonary function; CRC cis rs3820068 0.581 rs78175477 chr1:15948091 C/G cg24675056 chr1:15929824 NA 0.51 7.04 0.36 1.14e-11 Systolic blood pressure; CRC cis rs6500602 0.727 rs11644481 chr16:4581002 T/G cg14951292 chr16:4525986 HMOX2;NMRAL1 0.56 8.42 0.42 1.15e-15 Schizophrenia; CRC cis rs7044106 0.762 rs7849566 chr9:123460769 A/C cg09586646 chr9:123605570 PSMD5;LOC253039 0.63 8.78 0.44 9.26e-17 Hip circumference adjusted for BMI; CRC cis rs7756236 0.521 rs6907793 chr6:36625206 A/G cg08179530 chr6:36648295 CDKN1A 0.38 5.63 0.3 3.85e-8 QRS duration; CRC cis rs8180040 0.701 rs62248439 chr3:46996448 A/G cg02527881 chr3:46936655 PTH1R 0.41 7.33 0.37 1.78e-12 Colorectal cancer; CRC cis rs6952808 1.000 rs10260585 chr7:1889521 G/A cg23102388 chr7:1867652 MAD1L1 -0.33 -5.6 -0.3 4.46e-8 Bipolar disorder and schizophrenia; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg24044651 chr1:24105262 C1orf128 0.43 6.07 0.32 3.45e-9 Response to antipsychotic treatment; CRC cis rs875971 0.825 rs28480509 chr7:66099224 A/G cg18252515 chr7:66147081 NA 0.42 5.93 0.31 7.62e-9 Aortic root size; CRC trans rs9858542 0.953 rs34363169 chr3:49537712 G/A cg21582582 chr3:182698605 DCUN1D1 -0.51 -6.47 -0.34 3.47e-10 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs9660180 0.935 rs9786942 chr1:1759213 A/G cg13866156 chr1:1669148 SLC35E2 -0.64 -9.66 -0.47 1.3e-19 Body mass index; CRC cis rs4862750 0.881 rs6813866 chr4:187872161 T/G cg03452623 chr4:187889614 NA -0.9 -20.05 -0.74 5.59e-59 Lobe attachment (rater-scored or self-reported); CRC cis rs2734839 0.537 rs11214603 chr11:113279922 G/A cg14159747 chr11:113255604 NA 0.58 11.35 0.53 2.05e-25 Information processing speed; CRC trans rs2797160 1.000 rs1739371 chr6:126011291 G/A cg05039488 chr6:79577232 IRAK1BP1 0.49 7.18 0.37 4.57e-12 Endometrial cancer; CRC cis rs1129187 0.755 rs9471982 chr6:42935998 G/A cg09436375 chr6:42928200 GNMT -0.35 -6.46 -0.34 3.67e-10 Alzheimer's disease in APOE e4+ carriers; CRC cis rs60154123 0.505 rs2206043 chr1:210042983 G/A cg22029157 chr1:209979665 IRF6 0.6 6.66 0.34 1.14e-10 Coronary artery disease; CRC cis rs921968 0.541 rs561570 chr2:219379348 T/A cg02176678 chr2:219576539 TTLL4 0.54 8.69 0.43 1.78e-16 Mean corpuscular hemoglobin concentration; CRC cis rs1953600 0.837 rs2819946 chr10:81951635 G/A cg04850286 chr10:81895943 PLAC9 0.38 6.84 0.35 3.78e-11 Sarcoidosis; CRC cis rs2456568 0.802 rs1395386 chr11:93639331 A/G cg26875233 chr11:93583750 C11orf90 0.3 5.92 0.31 7.97e-9 Response to serotonin reuptake inhibitors in major depressive disorder; CRC cis rs17767392 0.595 rs8005615 chr14:71661187 A/G cg13720639 chr14:72061746 SIPA1L1 -0.47 -6.0 -0.31 5.16e-9 Mitral valve prolapse; CRC cis rs881375 0.967 rs10435843 chr9:123668033 A/G cg00246817 chr9:123691163 NA -0.47 -6.04 -0.32 4.11e-9 Rheumatoid arthritis; CRC cis rs11122272 0.735 rs2749717 chr1:231489353 G/T cg06096015 chr1:231504339 EGLN1 0.42 6.39 0.33 5.73e-10 Hemoglobin concentration; CRC trans rs1997103 0.906 rs2177806 chr7:55402609 A/T cg20935933 chr6:143382018 AIG1 0.52 6.72 0.35 7.8e-11 QRS interval (sulfonylurea treatment interaction); CRC cis rs2576037 0.526 rs1789152 chr18:44433092 G/T cg23996704 chr18:44553084 KATNAL2 -0.34 -7.06 -0.36 9.77e-12 Personality dimensions; CRC cis rs1552244 1.000 rs3895942 chr3:10108745 G/C cg16606324 chr3:10149918 C3orf24 0.67 9.13 0.45 6.91e-18 Alzheimer's disease; CRC cis rs4713118 0.868 rs2893928 chr6:27738430 C/A cg12172441 chr6:28176163 NA 0.61 6.56 0.34 2.13e-10 Parkinson's disease; CRC cis rs1707322 0.752 rs8179402 chr1:46142466 C/A cg03146154 chr1:46216737 IPP 0.67 9.75 0.47 6.98e-20 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs826838 0.967 rs4768330 chr12:39129399 T/C cg26384229 chr12:38710491 ALG10B -0.64 -9.63 -0.47 1.66e-19 Heart rate; CRC cis rs11785693 0.862 rs1156861 chr8:4984434 G/C cg26367366 chr8:4980734 NA 0.8 9.67 0.47 1.21e-19 Neuroticism (multi-trait analysis);Neuroticism; CRC cis rs11608355 0.515 rs2287192 chr12:109931594 C/T cg05360138 chr12:110035743 NA 0.74 8.23 0.41 4.5e-15 Neuroticism; CRC cis rs801193 0.935 rs2659899 chr7:66186721 A/G cg11764359 chr7:65958608 NA 0.54 8.31 0.42 2.57e-15 Aortic root size; CRC cis rs6860806 0.507 rs273915 chr5:131660119 G/C cg24060327 chr5:131705240 SLC22A5 -0.51 -7.68 -0.39 1.89e-13 Breast cancer; CRC cis rs2243480 1.000 rs906134 chr7:65444288 G/C cg12463550 chr7:65579703 CRCP 0.66 6.24 0.33 1.31e-9 Diabetic kidney disease; CRC cis rs1552244 0.554 rs3846169 chr3:9997054 A/G cg08888203 chr3:10149979 C3orf24 -0.47 -7.41 -0.38 1.08e-12 Alzheimer's disease; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg22104487 chr8:42010424 AP3M2 0.47 6.62 0.34 1.44e-10 Response to antipsychotic treatment; CRC cis rs736408 0.716 rs2239549 chr3:52823126 C/T cg07507251 chr3:52567010 NT5DC2 0.47 6.61 0.34 1.58e-10 Bipolar disorder; CRC cis rs938554 0.578 rs7663032 chr4:9993838 C/T cg11266682 chr4:10021025 SLC2A9 0.35 6.26 0.33 1.2e-9 Blood metabolite levels; CRC cis rs7914558 0.966 rs10748839 chr10:104953547 A/G cg04362960 chr10:104952993 NT5C2 0.6 8.79 0.44 8.21e-17 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs8062405 0.698 rs7188071 chr16:28917644 T/C cg08761264 chr16:28874980 SH2B1 0.44 5.81 0.3 1.5e-8 Cognitive ability (multi-trait analysis);Cognitive ability; CRC cis rs12541635 0.677 rs1496181 chr8:107027141 C/T cg10147462 chr8:107024639 NA 0.59 10.36 0.5 6.13e-22 Age of smoking initiation; CRC cis rs10779751 1.000 rs1205592 chr1:11305663 C/T cg08854313 chr1:11322531 MTOR 0.63 8.32 0.42 2.39e-15 Body mass index; CRC cis rs7772486 0.692 rs2265915 chr6:146194332 A/T cg23711669 chr6:146136114 FBXO30 0.74 12.97 0.58 2.31e-31 Lobe attachment (rater-scored or self-reported); CRC cis rs796364 0.951 rs7565005 chr2:201013277 A/G cg12253985 chr2:200820533 C2orf60;C2orf47 -0.52 -5.62 -0.3 4.15e-8 Schizophrenia; CRC cis rs9311474 0.508 rs6786919 chr3:52599789 A/G cg18404041 chr3:52824283 ITIH1 -0.41 -8.69 -0.43 1.71e-16 Electroencephalogram traits; CRC cis rs28386778 0.863 rs2665834 chr17:61904724 T/C cg25654072 chr17:61904446 PSMC5;FTSJ3 0.72 11.24 0.53 5.12e-25 Prudent dietary pattern; CRC cis rs9611565 0.694 rs5751107 chr22:41857812 A/G cg06634786 chr22:41940651 POLR3H 0.63 7.28 0.37 2.42e-12 Vitiligo; CRC cis rs919433 0.963 rs1896857 chr2:198164530 A/G cg03934865 chr2:198174659 NA -0.43 -7.18 -0.37 4.67e-12 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC cis rs9287719 0.967 rs4519489 chr2:10739087 A/T cg00105475 chr2:10696890 NA 0.45 7.3 0.37 2.19e-12 Prostate cancer; CRC cis rs9462027 0.628 rs9469857 chr6:34719793 C/T cg07306190 chr6:34760872 UHRF1BP1 -0.37 -6.6 -0.34 1.64e-10 Systemic lupus erythematosus; CRC cis rs11785400 0.793 rs4736364 chr8:143742113 C/T cg10596483 chr8:143751796 JRK 0.47 6.49 0.34 3.11e-10 Schizophrenia; CRC cis rs13161895 1.000 rs27018 chr5:179405144 A/G cg02702477 chr5:179499311 RNF130 0.54 6.28 0.33 1.08e-9 LDL cholesterol; CRC cis rs736408 0.505 rs2083180 chr3:52668119 G/T cg18099408 chr3:52552593 STAB1 -0.47 -8.05 -0.41 1.58e-14 Bipolar disorder; CRC cis rs4478858 0.684 rs11579845 chr1:31736248 A/G cg00250761 chr1:31883323 NA -0.43 -8.41 -0.42 1.3e-15 Alcohol dependence; CRC cis rs13191362 0.935 rs66923841 chr6:163177317 C/T cg06582575 chr6:163149167 PACRG;PARK2 0.89 11.35 0.53 2.01e-25 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs11112613 0.713 rs17037317 chr12:105952058 T/C cg03607813 chr12:105948248 NA 0.78 10.91 0.52 7.6e-24 Corrected insulin response;Corrected insulin response adjusted for insulin sensitivity index; CRC cis rs7493 0.755 rs13228784 chr7:94960825 A/G cg17330251 chr7:94953956 PON1 -0.49 -6.37 -0.33 6.27e-10 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs7715806 0.509 rs34349 chr5:74944868 A/G cg00601450 chr5:74908170 NA -0.47 -5.61 -0.3 4.3e-8 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs6500395 1.000 rs12934126 chr16:48705951 C/G cg04672837 chr16:48644449 N4BP1 -0.45 -6.63 -0.34 1.38e-10 Response to tocilizumab in rheumatoid arthritis; CRC cis rs6089584 0.888 rs6061405 chr20:60617033 A/G cg23262073 chr20:60523788 NA -0.46 -7.2 -0.37 4.16e-12 Body mass index; CRC cis rs2404602 0.735 rs56246286 chr15:76690731 C/T cg03037974 chr15:76606532 NA -0.5 -7.33 -0.37 1.84e-12 Blood metabolite levels; CRC cis rs12431939 0.947 rs56026555 chr14:51649066 G/T cg23942311 chr14:51606299 NA -0.56 -6.38 -0.33 5.84e-10 Cancer; CRC cis rs9322193 1.000 rs58189451 chr6:149921388 G/A cg13206674 chr6:150067644 NUP43 0.62 8.6 0.43 3.24e-16 Lung cancer; CRC cis rs4658101 0.815 rs12117800 chr1:92049014 C/T cg24006770 chr1:92056542 NA -0.45 -5.99 -0.31 5.5e-9 Optic disc area;Vertical cup-disc ratio; CRC cis rs7615952 0.688 rs12485622 chr3:125710739 T/C cg02807482 chr3:125708958 NA -0.46 -6.01 -0.31 4.92e-9 Blood pressure (smoking interaction); CRC cis rs1003719 0.586 rs2298685 chr21:38533390 C/T cg10648535 chr21:38446584 PIGP;TTC3 -0.48 -6.67 -0.35 1.08e-10 Eye color traits; CRC cis rs60871478 0.735 rs10950455 chr7:831451 C/T cg13844804 chr7:814759 HEATR2 -0.64 -6.89 -0.36 2.8e-11 Cerebrospinal P-tau181p levels; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg19998654 chr2:37458983 CEBPZ;C2orf56 0.45 7.31 0.37 1.99e-12 Liver disease severity in Alagille syndrome; CRC cis rs7727544 0.735 rs272875 chr5:131674888 T/C cg07395648 chr5:131743802 NA -0.39 -6.12 -0.32 2.6e-9 Blood metabolite levels; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg16629158 chr2:122042988 TFCP2L1 0.39 6.22 0.32 1.55e-9 Liver disease severity in Alagille syndrome; CRC cis rs12477438 0.765 rs13406288 chr2:99589585 T/C cg14399236 chr2:99771627 LIPT1;TSGA10 -0.6 -8.21 -0.41 5.18e-15 Chronic sinus infection; CRC cis rs1552244 0.554 rs7638846 chr3:10048601 A/G cg08888203 chr3:10149979 C3orf24 0.5 7.58 0.39 3.59e-13 Alzheimer's disease; CRC cis rs4660531 1.000 rs61774746 chr1:41838561 T/G cg00290994 chr1:41848739 NA 0.44 6.23 0.32 1.41e-9 Bipolar disorder; CRC cis rs6951245 1.000 rs80094748 chr7:1103958 G/A cg04025307 chr7:1156635 C7orf50 0.64 6.82 0.35 4.39e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs394563 0.934 rs384334 chr6:149796172 C/G cg07828024 chr6:149772892 ZC3H12D -0.47 -8.29 -0.42 3e-15 Dupuytren's disease; CRC cis rs1005277 0.579 rs176838 chr10:38371899 A/T cg00409905 chr10:38381863 ZNF37A 0.67 11.31 0.53 2.84e-25 Extrinsic epigenetic age acceleration; CRC cis rs2952156 0.652 rs11869286 chr17:37813856 C/G cg00129232 chr17:37814104 STARD3 -0.67 -11.86 -0.55 2.99e-27 Asthma; CRC cis rs801193 1.000 rs2707850 chr7:66203870 G/T cg00343986 chr7:65444356 GUSB 0.49 7.26 0.37 2.87e-12 Aortic root size; CRC cis rs1448094 0.621 rs7315084 chr12:86283817 A/G cg19622623 chr12:86230825 RASSF9 -0.36 -5.81 -0.3 1.5e-8 Major depressive disorder; CRC cis rs7666738 0.830 rs2865989 chr4:99067532 G/A cg17366294 chr4:99064904 C4orf37 0.43 7.32 0.37 1.87e-12 Colonoscopy-negative controls vs population controls; CRC cis rs9649213 0.593 rs6465675 chr7:97982103 C/T cg24562669 chr7:97807699 LMTK2 -0.45 -7.46 -0.38 7.54e-13 Prostate cancer (SNP x SNP interaction); CRC cis rs10274279 1.000 rs2021742 chr7:157381671 T/A cg26886268 chr7:157387156 PTPRN2 -0.48 -5.84 -0.31 1.23e-8 Myopia (pathological); CRC cis rs6598955 0.543 rs60433268 chr1:26548055 A/C cg04990556 chr1:26633338 UBXN11 0.87 10.58 0.5 1.04e-22 Obesity-related traits; CRC trans rs7647973 0.626 rs35129566 chr3:49866584 T/G cg21665057 chr3:196295764 WDR53;FBXO45 0.64 7.07 0.36 9.42e-12 Menarche (age at onset); CRC cis rs1023500 0.573 rs1807494 chr22:42474138 C/G cg04733989 chr22:42467013 NAGA -0.57 -8.74 -0.43 1.23e-16 Schizophrenia; CRC cis rs873946 0.648 rs12771651 chr10:134554482 C/A cg06453172 chr10:134556979 INPP5A -0.7 -8.5 -0.42 6.92e-16 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CRC cis rs4332037 0.851 rs1403175 chr7:1964357 A/T cg24505167 chr7:1915268 MAD1L1 0.41 5.95 0.31 7.03e-9 Bipolar disorder; CRC cis rs875971 0.545 rs2460427 chr7:65619205 T/C cg18876405 chr7:65276391 NA -0.44 -6.01 -0.31 5.02e-9 Aortic root size; CRC trans rs1656966 1.000 rs1656966 chr3:186466252 C/T cg20386580 chr10:105344807 NEURL 0.27 5.98 0.31 5.71e-9 Myopia (pathological); CRC cis rs4713118 0.662 rs149901 chr6:27965503 C/T cg06470822 chr6:28175283 NA 0.84 12.77 0.58 1.28e-30 Parkinson's disease; CRC cis rs10206020 0.885 rs11885392 chr2:1578182 C/A cg26248373 chr2:1572462 NA -0.81 -11.92 -0.55 1.74e-27 IgG glycosylation; CRC cis rs950169 1.000 rs35297609 chr15:84772896 A/G cg24253500 chr15:84953950 NA 0.38 6.49 0.34 3.23e-10 Schizophrenia; CRC cis rs654950 1.000 rs654950 chr1:41987868 G/C cg06885757 chr1:42089581 HIVEP3 -0.47 -7.78 -0.39 9.43e-14 Airway imaging phenotypes; CRC cis rs1707322 0.752 rs11211173 chr1:46219376 C/T cg06784218 chr1:46089804 CCDC17 0.65 12.05 0.55 5.8e-28 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs9487051 0.872 rs7772602 chr6:109608661 C/G cg12927641 chr6:109611667 NA 0.37 6.77 0.35 5.76e-11 Reticulocyte fraction of red cells; CRC cis rs9457247 1.000 rs376551 chr6:167384923 G/A cg23791538 chr6:167370224 RNASET2 -0.38 -5.97 -0.31 6.08e-9 Crohn's disease; CRC cis rs62432291 0.681 rs438853 chr6:159630352 A/C cg14500486 chr6:159655392 FNDC1 -0.72 -10.07 -0.49 5.9e-21 Joint mobility (Beighton score); CRC cis rs2019137 0.560 rs6707386 chr2:113981022 G/A cg01577475 chr2:114033581 PAX8;LOC440839 -0.26 -6.47 -0.34 3.61e-10 Lymphocyte counts; CRC cis rs56399783 0.901 rs56356906 chr7:2774383 G/A cg19731401 chr7:2775893 GNA12 0.66 7.14 0.37 5.98e-12 Childhood ear infection; CRC trans rs2727020 0.718 rs1404366 chr11:49415899 T/A cg03929089 chr4:120376271 NA -0.8 -11.46 -0.53 8.11e-26 Coronary artery disease; CRC cis rs61160187 0.582 rs1460961 chr5:60411832 A/G cg16298547 chr5:60138761 ELOVL7 -0.26 -5.66 -0.3 3.3e-8 Educational attainment (years of education);Educational attainment (college completion); CRC cis rs6427782 0.602 rs4915185 chr1:199822101 A/G cg07208853 chr1:200005219 NR5A2 0.22 5.69 0.3 2.81e-8 Menarche (age at onset); CRC cis rs7216064 1.000 rs12600941 chr17:65918807 A/G cg12091567 chr17:66097778 LOC651250 -0.67 -7.82 -0.4 7.06e-14 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CRC cis rs7208859 0.623 rs383436 chr17:28959179 A/G cg13385521 chr17:29058706 SUZ12P 0.61 6.58 0.34 1.84e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs6580649 0.941 rs1793931 chr12:48396505 G/T cg05342945 chr12:48394962 COL2A1 -0.46 -6.36 -0.33 6.58e-10 Lung cancer; CRC cis rs972578 1.000 rs2413737 chr22:43361143 C/G cg01576275 chr22:43409880 NA -0.45 -7.27 -0.37 2.62e-12 Mean platelet volume; CRC cis rs4780355 0.918 rs243323 chr16:11361202 A/G cg00044050 chr16:11439710 C16orf75 0.42 5.87 0.31 1.07e-8 Crohn's disease and psoriasis; CRC cis rs10504229 1.000 rs7007805 chr8:58179327 G/A cg24829409 chr8:58192753 C8orf71 -0.68 -11.34 -0.53 2.27e-25 Developmental language disorder (linguistic errors); CRC cis rs669446 0.529 rs6697354 chr1:44151015 T/G cg12908607 chr1:44402522 ARTN -0.34 -5.73 -0.3 2.21e-8 Amyotrophic lateral sclerosis (age of onset); CRC cis rs9388451 0.874 rs13209968 chr6:126089285 G/C cg05901451 chr6:126070800 HEY2 -0.66 -11.48 -0.53 6.95e-26 Brugada syndrome; CRC cis rs7605827 0.930 rs4668449 chr2:15530141 T/C cg19274914 chr2:15703543 NA 0.39 5.88 0.31 9.87e-9 Educational attainment (years of education); CRC cis rs733592 0.507 rs7138917 chr12:48455255 G/A cg21466736 chr12:48725269 NA 0.5 7.85 0.4 6.03e-14 Plateletcrit; CRC cis rs17376456 0.825 rs10064368 chr5:93266396 C/A cg21475434 chr5:93447410 FAM172A 0.83 8.23 0.41 4.37e-15 Diabetic retinopathy; CRC cis rs3785574 0.962 rs2597632 chr17:61894739 A/T cg06873352 chr17:61820015 STRADA 0.49 7.77 0.39 1e-13 Height; CRC cis rs6665290 0.904 rs9727512 chr1:227185375 G/T cg10327440 chr1:227177885 CDC42BPA -1.04 -22.87 -0.78 5.86e-70 Myeloid white cell count; CRC cis rs1218582 0.774 rs4845683 chr1:154877407 T/C cg03351412 chr1:154909251 PMVK 0.5 7.72 0.39 1.38e-13 Prostate cancer; CRC cis rs4332037 1.000 rs10240470 chr7:1949971 G/T cg25834613 chr7:1915315 MAD1L1 0.4 5.95 0.31 7.04e-9 Bipolar disorder; CRC cis rs514406 0.893 rs2897561 chr1:53388747 C/A cg24675658 chr1:53192096 ZYG11B -0.58 -8.54 -0.43 5.09e-16 Monocyte count; CRC cis rs6502050 0.731 rs35156322 chr17:80096323 T/C cg02741985 chr17:80059408 CCDC57 0.43 7.15 0.37 5.66e-12 Life satisfaction; CRC cis rs1448094 0.511 rs61930585 chr12:86158461 C/A cg18827107 chr12:86230957 RASSF9 -0.4 -6.08 -0.32 3.34e-9 Major depressive disorder; CRC cis rs9467711 0.651 rs13197334 chr6:26122648 G/C cg19084075 chr6:26124329 HIST1H2AC;HIST1H2BC 0.66 6.05 0.32 3.96e-9 Autism spectrum disorder or schizophrenia; CRC trans rs8108034 0.920 rs30480 chr19:39807213 A/G cg00455333 chr1:45205373 KIF2C -0.53 -6.19 -0.32 1.83e-9 Lung adenocarcinoma; CRC cis rs1552244 1.000 rs7631678 chr3:10078816 T/G cg10729496 chr3:10149963 C3orf24 0.55 7.11 0.37 7.07e-12 Alzheimer's disease; CRC cis rs1697139 0.583 rs6895853 chr5:66541427 T/C cg16691251 chr5:66510806 NA 0.44 7.82 0.4 7.09e-14 Breast cancer; CRC cis rs4665809 0.590 rs4665318 chr2:26424517 C/T cg26119090 chr2:26468346 HADHA;HADHB 1.07 15.52 0.65 3.98e-41 Gut microbiome composition (summer); CRC cis rs2576037 0.526 rs4890699 chr18:44541029 T/C cg23996704 chr18:44553084 KATNAL2 -0.41 -8.23 -0.41 4.43e-15 Personality dimensions; CRC cis rs736408 0.609 rs2230535 chr3:52800284 T/C cg11645453 chr3:52864694 ITIH4 0.36 6.16 0.32 2.18e-9 Bipolar disorder; CRC cis rs9549260 0.755 rs2755219 chr13:41169625 A/G cg21288729 chr13:41239152 FOXO1 0.4 6.08 0.32 3.35e-9 Red blood cell count; CRC cis rs1322512 1.000 rs2800630 chr6:153008261 A/G cg03415253 chr6:152958462 SYNE1 0.38 5.72 0.3 2.4e-8 Tonometry; CRC cis rs4862750 0.832 rs6836076 chr4:187899660 A/C cg06074448 chr4:187884817 NA -0.6 -11.3 -0.53 2.95e-25 Lobe attachment (rater-scored or self-reported); CRC cis rs9322193 0.847 rs868375 chr6:150166041 T/A cg13206674 chr6:150067644 NUP43 0.57 7.82 0.4 7.26e-14 Lung cancer; CRC cis rs1008375 1.000 rs1860596 chr4:17660082 C/T cg16339924 chr4:17578868 LAP3 0.55 7.37 0.38 1.38e-12 Parasitemia in Tripanosoma cruzi seropositivity; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg03056465 chr20:3026350 MRPS26;GNRH2 0.47 6.52 0.34 2.66e-10 Response to antipsychotic treatment; CRC cis rs9469578 0.792 rs79297236 chr6:33713930 T/C cg18708504 chr6:33715942 IP6K3 0.66 7.56 0.38 4e-13 Phosphorus levels; CRC cis rs9768139 0.733 rs34173461 chr7:158122175 C/G cg25566285 chr7:158114605 PTPRN2 0.46 7.11 0.36 7.41e-12 Calcium levels; CRC cis rs4700695 0.925 rs10069614 chr5:65396530 A/C cg21114390 chr5:65439923 SFRS12 -0.57 -7.06 -0.36 1.02e-11 Facial morphology (factor 19); CRC cis rs875971 1.000 rs7792762 chr7:66004138 T/C cg12463550 chr7:65579703 CRCP 0.47 6.51 0.34 2.87e-10 Aortic root size; CRC cis rs798554 0.757 rs1182185 chr7:2872233 A/G cg17321639 chr7:2759063 NA -0.48 -6.66 -0.34 1.17e-10 Height; CRC trans rs4853036 0.503 rs34198970 chr2:70012933 C/A cg14633329 chr9:139640053 LCN6 -0.39 -6.44 -0.33 4.26e-10 Colorectal or endometrial cancer; CRC cis rs10504229 0.683 rs79284841 chr8:58107611 T/A cg22535103 chr8:58192502 C8orf71 -0.8 -8.56 -0.43 4.32e-16 Developmental language disorder (linguistic errors); CRC cis rs2075371 0.501 rs1646652 chr7:134024515 A/T cg20476274 chr7:133979776 SLC35B4 0.56 8.7 0.43 1.63e-16 Mean platelet volume; CRC cis rs7666738 0.830 rs6851253 chr4:99029980 A/G cg17366294 chr4:99064904 C4orf37 0.44 7.48 0.38 6.96e-13 Colonoscopy-negative controls vs population controls; CRC cis rs921968 0.643 rs832801 chr2:219488698 G/A cg02176678 chr2:219576539 TTLL4 0.5 8.37 0.42 1.72e-15 Mean corpuscular hemoglobin concentration; CRC cis rs6484504 0.532 rs10835756 chr11:31267622 C/T cg14844989 chr11:31128820 NA -0.34 -5.95 -0.31 6.79e-9 Red blood cell count; CRC cis rs7586879 0.593 rs6733224 chr2:25130907 C/T cg22495460 chr2:25135724 ADCY3 0.88 17.77 0.7 5.57e-50 Body mass index; CRC cis rs2033711 0.870 rs11669741 chr19:58960481 C/T cg13877915 chr19:58951672 ZNF132 -0.45 -7.5 -0.38 6.06e-13 Uric acid clearance; CRC cis rs7937682 0.824 rs577044 chr11:111490420 G/T cg09085632 chr11:111637200 PPP2R1B -0.98 -19.2 -0.73 1.2e-55 Primary sclerosing cholangitis; CRC cis rs7605827 0.930 rs7602186 chr2:15510003 C/T cg19274914 chr2:15703543 NA 0.38 5.76 0.3 1.97e-8 Educational attainment (years of education); CRC cis rs2952156 1.000 rs2643195 chr17:37853118 A/G cg11212589 chr17:38028394 ZPBP2 0.35 5.92 0.31 8.16e-9 Asthma; CRC cis rs262150 0.544 rs2428780 chr7:158812471 T/A cg12590608 chr7:158785262 NA 0.33 5.81 0.31 1.45e-8 Facial morphology (factor 20); CRC trans rs11098499 0.954 rs9685777 chr4:120365965 C/A cg25214090 chr10:38739885 LOC399744 0.66 10.47 0.5 2.41e-22 Corneal astigmatism; CRC cis rs4820294 1.000 rs7291867 chr22:38062112 C/G cg21798802 chr22:38057573 PDXP 0.48 7.52 0.38 5.43e-13 Fat distribution (HIV); CRC cis rs9916302 0.898 rs8072297 chr17:37478048 A/T cg15445000 chr17:37608096 MED1 -0.41 -8.79 -0.44 8.33e-17 Glomerular filtration rate (creatinine); CRC cis rs10791097 0.694 rs11222369 chr11:130744670 A/G cg12179176 chr11:130786555 SNX19 0.75 12.66 0.57 3.46e-30 Autism spectrum disorder or schizophrenia;Schizophrenia; CRC cis rs2976388 0.609 rs2585145 chr8:143799457 G/A cg20041105 chr8:143859282 LYNX1 0.46 8.03 0.4 1.72e-14 Urinary tract infection frequency; CRC cis rs1506636 0.962 rs2456551 chr7:123394610 C/G cg03229431 chr7:123269106 ASB15 0.72 11.4 0.53 1.38e-25 Plateletcrit;Platelet count; CRC cis rs57590327 0.555 rs3772884 chr3:81802720 G/T cg07356753 chr3:81810745 GBE1 -0.61 -8.37 -0.42 1.65e-15 Extraversion; CRC cis rs7044106 0.762 rs966396 chr9:123453281 T/C cg14255062 chr9:123606675 PSMD5;LOC253039 0.45 6.5 0.34 2.94e-10 Hip circumference adjusted for BMI; CRC cis rs2762353 0.574 rs16890999 chr6:25755583 A/G cg03517284 chr6:25882590 NA 0.74 10.46 0.5 2.8e-22 Blood metabolite levels; CRC cis rs9611565 0.765 rs202659 chr22:41811620 T/C cg06481639 chr22:41940642 POLR3H 0.49 5.63 0.3 3.89e-8 Vitiligo; CRC cis rs425277 0.606 rs424079 chr1:2071340 C/A cg12639453 chr1:2035780 PRKCZ -0.33 -6.17 -0.32 1.99e-9 Height; CRC cis rs9894429 0.816 rs7406040 chr17:79597583 A/C cg21028142 chr17:79581711 NPLOC4 0.32 6.85 0.35 3.68e-11 Eye color traits; CRC trans rs10983614 1.000 rs7867776 chr9:120072627 A/G cg03864326 chr16:67927170 PSKH1 0.42 6.0 0.31 5.18e-9 Survival in pancreatic cancer; CRC cis rs3750082 0.855 rs12536402 chr7:32936419 C/G cg05721444 chr7:32995514 FKBP9 -0.48 -7.29 -0.37 2.26e-12 Glomerular filtration rate (creatinine); CRC cis rs4713118 0.869 rs6930992 chr6:27712120 A/C cg06470822 chr6:28175283 NA 0.71 10.07 0.49 5.85e-21 Parkinson's disease; CRC trans rs1814175 0.588 rs10466497 chr11:49864381 A/T cg03929089 chr4:120376271 NA -0.91 -15.77 -0.66 4.09e-42 Height; CRC cis rs9325144 0.560 rs10785573 chr12:38654166 G/A cg26384229 chr12:38710491 ALG10B -0.56 -8.38 -0.42 1.54e-15 Morning vs. evening chronotype; CRC cis rs4975616 0.869 rs455433 chr5:1336243 A/G cg26373071 chr5:1325741 CLPTM1L 0.55 10.21 0.49 1.97e-21 Lung cancer; CRC cis rs2806561 0.894 rs598438 chr1:23531563 C/T cg19743168 chr1:23544995 NA 0.39 6.0 0.31 5.13e-9 Height; CRC cis rs13108904 0.901 rs1316393 chr4:1315619 A/G cg19318889 chr4:1322082 MAEA -0.42 -6.08 -0.32 3.36e-9 Obesity-related traits; CRC cis rs1801251 0.835 rs1446310 chr2:233683245 G/C cg25237894 chr2:233734115 C2orf82 -0.44 -6.86 -0.35 3.36e-11 Coronary artery disease; CRC cis rs4654899 0.865 rs72988025 chr1:21351441 A/G cg02927042 chr1:21476669 EIF4G3 -0.5 -7.93 -0.4 3.45e-14 Superior frontal gyrus grey matter volume; CRC cis rs34172651 0.517 rs874484 chr16:24803242 T/C cg06028605 chr16:24865363 SLC5A11 0.55 8.4 0.42 1.39e-15 Intelligence (multi-trait analysis); CRC cis rs926938 0.967 rs11587596 chr1:115241857 A/G cg12756093 chr1:115239321 AMPD1 -0.72 -11.57 -0.54 3.27e-26 Autism; CRC cis rs713587 0.713 rs12466350 chr2:25239969 A/G cg04586622 chr2:25135609 ADCY3 -0.39 -6.68 -0.35 9.93e-11 Body mass index in non-asthmatics; CRC cis rs79349575 0.749 rs957557 chr17:47003221 G/T cg22482690 chr17:47019901 SNF8 0.47 7.94 0.4 3.17e-14 Type 2 diabetes; CRC cis rs875971 0.522 rs709604 chr7:65497434 A/G cg11764359 chr7:65958608 NA -0.52 -7.9 -0.4 4.13e-14 Aortic root size; CRC cis rs4363385 0.693 rs689008 chr1:153047100 G/C cg25856811 chr1:152973957 SPRR3 -0.24 -6.58 -0.34 1.86e-10 Inflammatory skin disease; CRC cis rs17270561 0.609 rs1892248 chr6:25768914 C/T cg17691542 chr6:26056736 HIST1H1C 0.67 8.34 0.42 2.07e-15 Iron status biomarkers; CRC cis rs1862618 0.853 rs6450409 chr5:56101399 A/G cg12311346 chr5:56204834 C5orf35 -0.72 -9.45 -0.46 6.41e-19 Initial pursuit acceleration; CRC cis rs1005277 0.579 rs2505198 chr10:38393183 A/C cg25427524 chr10:38739819 LOC399744 -0.77 -14.06 -0.61 1.68e-35 Extrinsic epigenetic age acceleration; CRC cis rs10504229 0.683 rs55645894 chr8:58116145 A/G cg05313129 chr8:58192883 C8orf71 -0.43 -6.11 -0.32 2.74e-9 Developmental language disorder (linguistic errors); CRC cis rs76993477 0.610 rs115822670 chr1:169711885 T/C cg03211132 chr1:169703751 SELE 0.58 5.7 0.3 2.72e-8 Tonsillectomy; CRC cis rs60843830 0.661 rs55987018 chr2:106655 C/T cg25945732 chr2:264204 ACP1;SH3YL1 0.46 6.41 0.33 5.09e-10 Spherical equivalent (joint analysis main effects and education interaction); CRC cis rs2635047 0.935 rs2635050 chr18:44664131 G/A cg19077165 chr18:44547161 KATNAL2 -0.45 -7.2 -0.37 4.22e-12 Educational attainment; CRC cis rs7618915 0.501 rs34157897 chr3:52716937 T/C cg18099408 chr3:52552593 STAB1 -0.47 -8.0 -0.4 2.22e-14 Bipolar disorder; CRC cis rs2710642 0.962 rs6545972 chr2:63084682 G/A cg17519650 chr2:63277830 OTX1 0.44 6.27 0.33 1.14e-9 LDL cholesterol levels;LDL cholesterol; CRC cis rs9398803 0.865 rs4418209 chr6:126819699 T/G cg19875578 chr6:126661172 C6orf173 0.42 5.86 0.31 1.15e-8 Male-pattern baldness; CRC cis rs11677416 1.000 rs61381693 chr2:113525912 C/A cg27083787 chr2:113543245 IL1A 0.51 7.1 0.36 7.83e-12 Response to antipsychotic treatment in schizophrenia (working memory); CRC cis rs11792861 0.855 rs116127510 chr9:111868344 G/A cg05043794 chr9:111880884 C9orf5 -0.36 -6.55 -0.34 2.2e-10 Menarche (age at onset); CRC cis rs7552404 1.000 rs4949872 chr1:76131392 C/G cg22875332 chr1:76189707 ACADM 0.68 9.17 0.45 5.38e-18 Blood metabolite levels;Acylcarnitine levels; CRC cis rs6089584 0.854 rs8117075 chr20:60613766 T/C cg18761221 chr20:60518478 NA 0.46 7.36 0.38 1.53e-12 Body mass index; CRC cis rs79387448 0.745 rs7587856 chr2:103144305 C/A cg09003973 chr2:102972529 NA 0.73 8.14 0.41 8.53e-15 Gut microbiota (bacterial taxa); CRC cis rs9858542 0.953 rs9824092 chr3:49674147 C/G cg00383909 chr3:49044727 WDR6 0.49 6.16 0.32 2.08e-9 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs2479724 0.846 rs2251084 chr6:41838119 T/C cg17623882 chr6:41773611 USP49 -0.53 -8.82 -0.44 6.82e-17 Menarche (age at onset); CRC cis rs7264396 0.563 rs2425084 chr20:34301871 C/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.51 -7.21 -0.37 3.76e-12 Total cholesterol levels; CRC cis rs1950626 0.623 rs34603287 chr14:101433831 G/A cg02351406 chr14:101447389 SNORD114-20;SNORD114-21 0.75 12.07 0.55 5.21e-28 Pelvic organ prolapse (moderate/severe); CRC cis rs524281 0.861 rs10791858 chr11:65978396 A/G cg16950941 chr11:66035639 RAB1B -0.66 -7.87 -0.4 5.28e-14 Electroencephalogram traits; CRC cis rs9659323 0.700 rs10923746 chr1:119616278 A/G cg26570165 chr1:119541833 NA -0.36 -5.91 -0.31 8.72e-9 Body mass index; CRC cis rs2227564 0.672 rs2461864 chr10:75659872 A/T cg00564723 chr10:75632066 CAMK2G -0.32 -7.14 -0.37 5.99e-12 Crohn's disease;Inflammatory bowel disease; CRC cis rs9486715 0.867 rs9373833 chr6:96904998 A/G cg18709589 chr6:96969512 KIAA0776 -0.49 -7.26 -0.37 2.79e-12 Headache; CRC cis rs1862618 0.671 rs2591964 chr5:56236900 T/G cg03609598 chr5:56110824 MAP3K1 0.58 7.79 0.39 8.61e-14 Initial pursuit acceleration; CRC cis rs7258465 0.931 rs7249020 chr19:18608147 A/G cg06462663 chr19:18546047 ISYNA1 0.46 7.07 0.36 9.28e-12 Breast cancer; CRC cis rs4689388 0.926 rs10012946 chr4:6293350 C/T cg14416269 chr4:6271139 WFS1 -0.42 -6.63 -0.34 1.36e-10 Type 2 diabetes and other traits;Type 2 diabetes; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg24796471 chr19:6737389 GPR108 0.46 6.13 0.32 2.54e-9 Anxiety disorder; CRC cis rs11971779 0.680 rs6467840 chr7:139065401 A/T cg07862535 chr7:139043722 LUC7L2 0.57 7.35 0.38 1.61e-12 Diisocyanate-induced asthma; CRC cis rs9430161 0.598 rs34350247 chr1:11034460 A/G cg27631724 chr1:11040367 C1orf127 0.32 6.39 0.33 5.73e-10 Ewing sarcoma; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg10893140 chr3:49158297 USP19 0.45 6.45 0.34 3.94e-10 Anxiety disorder; CRC cis rs8016982 0.674 rs1951614 chr14:81672106 A/G cg01989461 chr14:81687754 GTF2A1 -0.58 -9.46 -0.46 6.21e-19 Schizophrenia; CRC cis rs883565 0.740 rs6763016 chr3:39098964 G/A cg01426195 chr3:39028469 NA -0.54 -8.66 -0.43 2.15e-16 Handedness; CRC trans rs2228479 0.867 rs57492102 chr16:89975572 A/G cg21302420 chr1:112162376 RAP1A 0.65 6.41 0.33 5.02e-10 Skin colour saturation; CRC cis rs11686934 0.780 rs6731423 chr2:70173327 A/C cg02498382 chr2:70120550 SNRNP27 -0.5 -8.47 -0.42 8.32e-16 High light scatter reticulocyte count; CRC cis rs4423214 1.000 rs4944959 chr11:71168234 C/T cg05163923 chr11:71159392 DHCR7 -0.6 -8.49 -0.42 7.04e-16 Vitamin D levels; CRC trans rs7615952 1.000 rs7615952 chr3:125649403 A/C cg07211511 chr3:129823064 LOC729375 1.04 17.67 0.7 1.35e-49 Blood pressure (smoking interaction); CRC cis rs10256972 0.577 rs6962809 chr7:1208889 A/G cg18765753 chr7:1198926 ZFAND2A -0.47 -8.33 -0.42 2.17e-15 Longevity;Endometriosis; CRC cis rs6499255 0.857 rs16959035 chr16:69707645 C/A cg04110750 chr16:69646130 NFAT5 -0.51 -7.22 -0.37 3.59e-12 IgE levels; CRC cis rs9811920 0.609 rs793460 chr3:99615733 G/A cg07805332 chr3:99536008 MIR548G;C3orf26 -0.51 -7.68 -0.39 1.84e-13 Axial length; CRC cis rs7762018 0.556 rs75659875 chr6:170054800 A/C cg24289452 chr6:170231220 NA -0.81 -7.11 -0.36 7.23e-12 Thiazide-induced adverse metabolic effects in hypertensive patients; CRC cis rs7613875 0.600 rs2624832 chr3:50030858 C/T cg24110177 chr3:50126178 RBM5 -0.54 -8.09 -0.41 1.19e-14 Body mass index; CRC cis rs9457247 0.765 rs9457256 chr6:167436461 T/C cg07741184 chr6:167504864 NA 0.4 6.78 0.35 5.58e-11 Crohn's disease; CRC cis rs9323205 0.798 rs11157805 chr14:51658390 C/G cg23942311 chr14:51606299 NA 0.6 9.33 0.46 1.59e-18 Cancer; CRC cis rs2737618 0.651 rs2249172 chr1:200082955 A/G cg21825944 chr1:200113062 NR5A2 0.45 6.64 0.34 1.28e-10 Uric acid levels; CRC cis rs13118159 0.550 rs28522910 chr4:1374774 C/T cg16405210 chr4:1374714 KIAA1530 -0.94 -15.5 -0.65 4.47e-41 Longevity; CRC trans rs7647973 0.593 rs58339610 chr3:49845006 T/A cg21665057 chr3:196295764 WDR53;FBXO45 0.64 7.05 0.36 1.08e-11 Menarche (age at onset); CRC cis rs7119 0.679 rs34075648 chr15:77847802 G/C cg10437265 chr15:77819839 NA 0.59 9.97 0.48 1.23e-20 Type 2 diabetes; CRC cis rs4363385 0.818 rs378010 chr1:153007987 A/G cg25856811 chr1:152973957 SPRR3 -0.27 -7.37 -0.38 1.43e-12 Inflammatory skin disease; CRC cis rs6582630 0.537 rs8189533 chr12:38391068 A/G cg26384229 chr12:38710491 ALG10B 0.68 8.96 0.44 2.5e-17 Drug-induced liver injury (flucloxacillin); CRC cis rs1448094 0.817 rs7973694 chr12:86335589 A/G cg00310523 chr12:86230176 RASSF9 0.44 7.49 0.38 6.47e-13 Major depressive disorder; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg26298387 chr1:160068041 IGSF8 0.45 6.32 0.33 8.75e-10 Response to antipsychotic treatment; CRC cis rs2204008 0.715 rs11495369 chr12:38238673 T/C cg13010199 chr12:38710504 ALG10B 0.45 5.8 0.3 1.52e-8 Bladder cancer; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg17142723 chr17:41324085 NBR1 0.36 6.8 0.35 4.97e-11 Liver disease severity in Alagille syndrome; CRC cis rs1865760 0.532 rs2794719 chr6:26088890 T/G cg18357526 chr6:26021779 HIST1H4A 0.43 5.97 0.31 6.13e-9 Height; CRC cis rs1003719 0.688 rs2000413 chr21:38539718 G/A cg10648535 chr21:38446584 PIGP;TTC3 -0.48 -6.5 -0.34 3.03e-10 Eye color traits; CRC cis rs8072100 0.846 rs4264433 chr17:45737275 A/T cg25173405 chr17:45401733 C17orf57 0.46 7.33 0.37 1.75e-12 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs7258465 1.000 rs4808804 chr19:18585325 A/G cg10790698 chr19:18539756 SSBP4 -0.45 -8.59 -0.43 3.63e-16 Breast cancer; CRC cis rs7904368 0.806 rs7900527 chr10:16857992 C/G cg14835575 chr10:16859367 RSU1 0.45 6.1 0.32 2.99e-9 Ratio of the peak velocity of the mitral E-Wave divided by the peak velocity of the mitral A-wave.; CRC cis rs6585424 1.000 rs6585424 chr10:81933748 A/G cg11900509 chr10:81946545 ANXA11 -0.72 -8.83 -0.44 6.14e-17 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs10504229 0.728 rs1495867 chr8:58155500 G/T cg24829409 chr8:58192753 C8orf71 -0.58 -7.96 -0.4 2.86e-14 Developmental language disorder (linguistic errors); CRC cis rs7927771 1.000 rs9909 chr11:47799775 C/G cg18512352 chr11:47633146 NA -0.49 -9.48 -0.46 5.08e-19 Subjective well-being; CRC cis rs12701220 0.500 rs6463224 chr7:1140418 C/A cg00990874 chr7:1149470 C7orf50 -0.49 -6.28 -0.33 1.07e-9 Bronchopulmonary dysplasia; CRC cis rs28386778 0.897 rs6504176 chr17:61811920 T/C cg23090583 chr17:61904693 PSMC5;FTSJ3 1.03 19.35 0.73 3.19e-56 Prudent dietary pattern; CRC cis rs73200209 0.703 rs17498942 chr12:116686117 C/G cg01776926 chr12:116560359 MED13L -0.61 -7.27 -0.37 2.66e-12 Total body bone mineral density; CRC cis rs2559856 1.000 rs2559858 chr12:102089300 A/G cg12924262 chr12:102091054 CHPT1 0.54 8.15 0.41 7.91e-15 Blood protein levels; CRC cis rs4561483 0.583 rs11645213 chr16:11942924 C/A cg08843971 chr16:11963173 GSPT1 0.52 7.82 0.4 7.18e-14 Testicular germ cell tumor; CRC cis rs4499344 0.633 rs259251 chr19:33149768 G/A cg08127369 chr19:33164662 ANKRD27 0.39 5.95 0.31 6.82e-9 Mean platelet volume; CRC cis rs7412746 0.611 rs11803940 chr1:150685835 A/G cg17724175 chr1:150552817 MCL1 0.58 9.34 0.46 1.54e-18 Melanoma; CRC cis rs2811415 0.531 rs13063727 chr3:127767618 C/G cg13719885 chr3:127795394 NA -0.37 -5.65 -0.3 3.49e-8 Lung function (FEV1/FVC); CRC cis rs2842992 0.692 rs1128661 chr6:160211554 T/G cg19482086 chr6:160211437 TCP1;MRPL18 0.84 13.56 0.6 1.38e-33 Age-related macular degeneration (geographic atrophy); CRC cis rs6502050 0.626 rs11868521 chr17:80100195 T/G cg09264619 chr17:80180166 NA 0.41 6.76 0.35 6.46e-11 Life satisfaction; CRC cis rs7824557 0.583 rs2736306 chr8:11239762 A/T cg20542592 chr8:11973495 FAM66D -0.34 -5.69 -0.3 2.84e-8 Retinal vascular caliber; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg25485084 chr12:118809325 TAOK3 0.47 7.24 0.37 3.17e-12 Response to antipsychotic treatment; CRC cis rs4427176 0.765 rs17150478 chr8:9641034 C/T cg21625330 chr8:9911636 MSRA 0.64 6.27 0.33 1.14e-9 Mosquito bite size; CRC cis rs2228479 0.717 rs12917681 chr16:89810941 C/A cg19635926 chr16:89946313 TCF25 0.56 5.95 0.31 6.86e-9 Skin colour saturation; CRC cis rs1799949 1.000 rs4340367 chr17:41307772 G/A cg05368731 chr17:41323189 NBR1 0.69 10.51 0.5 1.74e-22 Menopause (age at onset); CRC cis rs7552404 0.727 rs7547508 chr1:76327958 A/G cg05598546 chr1:76251766 SNORD45C;RABGGTB -0.51 -5.87 -0.31 1.06e-8 Blood metabolite levels;Acylcarnitine levels; CRC cis rs3858526 0.676 rs10838772 chr11:5895754 T/C cg26762873 chr11:5879799 OR52E8 -0.47 -6.58 -0.34 1.88e-10 DNA methylation (variation); CRC cis rs2842992 0.789 rs9364536 chr6:160225559 G/C cg11366901 chr6:160182831 ACAT2 0.97 13.91 0.61 6.76e-35 Age-related macular degeneration (geographic atrophy); CRC trans rs6703335 0.870 rs10803142 chr1:243598234 A/G cg07336999 chr16:89939803 TCF25 0.42 6.19 0.32 1.83e-9 Schizophrenia;Schizophrenia, schizoaffective disorder or bipolar disorder; CRC cis rs9875589 0.509 rs2607761 chr3:14091428 A/G cg14375111 chr3:14165186 TMEM43;CHCHD4 0.41 6.27 0.33 1.11e-9 Ovarian reserve; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg14699228 chr3:49823994 IP6K1 -0.41 -6.56 -0.34 2.12e-10 Myopia (pathological); CRC cis rs4700695 0.925 rs1845481 chr5:65397527 A/C cg21114390 chr5:65439923 SFRS12 -0.49 -6.35 -0.33 7.17e-10 Facial morphology (factor 19); CRC cis rs8177253 0.530 rs8177177 chr3:133463195 A/G cg16262614 chr3:133464971 TF 0.43 8.05 0.41 1.5e-14 Iron status biomarkers; CRC cis rs853679 0.517 rs9393888 chr6:28059217 G/C cg25164649 chr6:28176230 NA 0.75 9.36 0.46 1.32e-18 Depression; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg26928467 chr16:577442 SOLH;C16orf10 0.41 6.37 0.33 6.19e-10 Liver disease severity in Alagille syndrome; CRC cis rs10256972 0.713 rs10435026 chr7:1065948 A/G cg18402987 chr7:1209562 NA 0.43 6.23 0.33 1.39e-9 Longevity;Endometriosis; CRC cis rs4972806 0.849 rs1542180 chr2:177028767 C/T cg03152288 chr2:177042942 NA 0.79 12.56 0.57 8.27e-30 IgG glycosylation; CRC cis rs3733346 0.520 rs62297086 chr4:909040 G/A cg04824913 chr4:887549 GAK 0.48 6.63 0.34 1.39e-10 Sjögren's syndrome; CRC cis rs1448094 0.510 rs11117016 chr12:86141602 T/C cg19622623 chr12:86230825 RASSF9 0.41 6.35 0.33 7.04e-10 Major depressive disorder; CRC cis rs35146811 0.735 rs1636975 chr7:99812089 A/G cg00553149 chr7:99775558 STAG3;GPC2 -0.24 -5.61 -0.3 4.38e-8 Coronary artery disease; CRC cis rs4148883 0.651 rs4147547 chr4:100127311 G/T cg13256891 chr4:100009986 ADH5 0.44 6.3 0.33 9.57e-10 Alcohol dependence; CRC cis rs2842992 0.692 rs9347342 chr6:160193129 T/C cg19482086 chr6:160211437 TCP1;MRPL18 0.83 13.49 0.6 2.56e-33 Age-related macular degeneration (geographic atrophy); CRC cis rs2230307 0.536 rs7518943 chr1:100463422 G/T cg24955406 chr1:100503596 HIAT1 0.58 7.12 0.37 7e-12 Carotid intima media thickness; CRC cis rs11098499 0.697 rs10020027 chr4:120381879 G/C cg09307838 chr4:120376055 NA 0.71 11.02 0.52 3.08e-24 Corneal astigmatism; CRC trans rs11343 0.675 rs7359333 chr16:19262344 A/T cg27001607 chr7:76178636 LOC100133091 -0.51 -6.68 -0.35 1.02e-10 Parkinson's disease; CRC cis rs3806843 0.735 rs778597 chr5:140040665 A/G cg16607685 chr5:140181889 PCDHA2;PCDHA1;PCDHA3 -0.26 -5.81 -0.31 1.46e-8 Depressive symptoms (multi-trait analysis); CRC cis rs2749592 0.531 rs1208559 chr10:38221370 T/C cg25427524 chr10:38739819 LOC399744 0.77 13.6 0.6 1.02e-33 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs11212617 0.837 rs4754298 chr11:108023284 G/A cg01991180 chr11:108092276 ATM;NPAT 0.41 6.07 0.32 3.52e-9 Response to metformin in type 2 diabetes (glycemic); CRC cis rs6570726 0.905 rs388728 chr6:145816419 T/C cg23711669 chr6:146136114 FBXO30 0.68 12.05 0.55 6.18e-28 Lobe attachment (rater-scored or self-reported); CRC cis rs9916302 0.904 rs55689507 chr17:37404436 G/C cg03013999 chr17:37608204 MED1 0.49 7.45 0.38 8.46e-13 Glomerular filtration rate (creatinine); CRC cis rs4819052 0.807 rs7283915 chr21:46671288 T/C cg02159808 chr21:46707872 POFUT2;LOC642852 0.49 6.51 0.34 2.89e-10 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs9322193 0.923 rs10782318 chr6:150075273 A/G cg13206674 chr6:150067644 NUP43 0.66 9.38 0.46 1.08e-18 Lung cancer; CRC cis rs1448094 0.556 rs61930626 chr12:86167445 A/G cg18827107 chr12:86230957 RASSF9 -0.41 -6.23 -0.32 1.42e-9 Major depressive disorder; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg03208016 chr1:180124071 QSOX1 0.44 6.01 0.31 4.82e-9 Anxiety disorder; CRC cis rs2243480 1.000 rs9769882 chr7:65642925 T/C cg25985355 chr7:65971099 NA 0.52 6.01 0.31 4.92e-9 Diabetic kidney disease; CRC cis rs6502050 0.835 rs67149434 chr17:80128007 G/A cg22110888 chr17:80059540 CCDC57 0.4 6.43 0.33 4.37e-10 Life satisfaction; CRC cis rs13108904 0.905 rs1680074 chr4:1279621 G/A cg02018176 chr4:1364513 KIAA1530 -0.42 -7.2 -0.37 4.18e-12 Obesity-related traits; CRC cis rs6589219 0.908 rs10789822 chr11:111162691 A/G cg25129781 chr11:111156908 C11orf53 -0.31 -5.76 -0.3 1.96e-8 Colorectal cancer; CRC cis rs7258465 1.000 rs10409505 chr19:18590251 C/G cg01065977 chr19:18549689 ISYNA1 -0.41 -6.39 -0.33 5.59e-10 Breast cancer; CRC cis rs832540 0.966 rs33321 chr5:56206073 G/T cg20203395 chr5:56204925 C5orf35 -0.41 -5.77 -0.3 1.88e-8 Coronary artery disease; CRC cis rs35110281 0.782 rs9981790 chr21:45045052 G/C cg04455712 chr21:45112962 RRP1B 0.4 7.6 0.39 3.11e-13 Mean corpuscular volume; CRC cis rs9902453 1.000 rs11080114 chr17:28407287 C/T cg26525008 chr17:28256777 EFCAB5;SSH2 -0.59 -8.9 -0.44 3.84e-17 Coffee consumption (cups per day); CRC cis rs11758351 0.587 rs16891456 chr6:26234127 T/C cg22723502 chr6:26240528 HIST1H4F -0.36 -5.92 -0.31 8.02e-9 Gout;Renal underexcretion gout; CRC trans rs1814175 0.645 rs847630 chr11:49926360 C/T cg03929089 chr4:120376271 NA -0.91 -16.07 -0.66 2.65e-43 Height; CRC cis rs6502050 0.731 rs11867299 chr17:80088675 C/A cg19223190 chr17:80058835 NA 0.39 6.16 0.32 2.12e-9 Life satisfaction; CRC cis rs2380220 0.935 rs7748857 chr6:96001887 A/G cg07718321 chr6:96025334 MANEA 0.49 5.82 0.31 1.38e-8 Behavioural disinhibition (generation interaction); CRC cis rs3764400 0.506 rs2036521 chr17:46328976 T/G cg10706073 chr17:46328419 SKAP1 -0.65 -6.69 -0.35 9.62e-11 Body mass index; CRC cis rs1552244 1.000 rs67852463 chr3:10157205 G/C cg08888203 chr3:10149979 C3orf24 0.73 9.77 0.47 5.72e-20 Alzheimer's disease; CRC cis rs1552244 0.882 rs13088350 chr3:10044626 T/C cg16606324 chr3:10149918 C3orf24 0.62 8.08 0.41 1.25e-14 Alzheimer's disease; CRC cis rs13118159 0.899 rs3796613 chr4:1353321 A/T cg15763984 chr4:1342303 KIAA1530 0.47 8.08 0.41 1.23e-14 Longevity; CRC cis rs728616 0.867 rs61860041 chr10:81944331 G/A cg05935833 chr10:81318306 SFTPA2 -0.72 -7.91 -0.4 3.91e-14 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs9916302 0.904 rs801419 chr17:37466327 A/G cg00129232 chr17:37814104 STARD3 0.55 8.04 0.41 1.62e-14 Glomerular filtration rate (creatinine); CRC cis rs9457247 0.935 rs2149093 chr6:167373045 T/C cg23791538 chr6:167370224 RNASET2 0.37 5.85 0.31 1.21e-8 Crohn's disease; CRC cis rs7224685 0.501 rs781842 chr17:3958955 C/T cg09695851 chr17:3907499 NA 0.77 14.76 0.63 3.56e-38 Type 2 diabetes; CRC cis rs1153858 1.000 rs4774577 chr15:45644685 A/C cg10760299 chr15:45669010 GATM 0.49 7.79 0.39 8.71e-14 Homoarginine levels; CRC cis rs2281845 0.929 rs6704363 chr1:201096383 A/G cg01987224 chr1:201084466 NA 0.52 9.5 0.46 4.34e-19 Permanent tooth development; CRC cis rs9611565 0.559 rs4822049 chr22:41993496 G/A cg03806693 chr22:41940476 POLR3H -1.04 -11.6 -0.54 2.54e-26 Vitiligo; CRC cis rs7659604 0.846 rs60340409 chr4:122666355 G/C cg19748678 chr4:122722346 EXOSC9 0.55 8.67 0.43 2.02e-16 Type 2 diabetes; CRC cis rs17767392 0.881 rs12880188 chr14:72009745 C/G cg13720639 chr14:72061746 SIPA1L1 -0.48 -6.66 -0.34 1.13e-10 Mitral valve prolapse; CRC cis rs887829 0.569 rs3806596 chr2:234637707 C/T cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 0.47 7.31 0.37 2.07e-12 Metabolic traits;Bilirubin levels;Cholelithiasis-related traits in sickle cell anemia;Metabolite levels;Total bilirubin levels in HIV-1 infection;Serum metabolite levels;Blood metabolite levels; CRC cis rs2811415 0.597 rs9819960 chr3:127784513 T/C cg13719885 chr3:127795394 NA -0.39 -5.95 -0.31 6.69e-9 Lung function (FEV1/FVC); CRC cis rs11123170 0.529 rs1015755 chr2:113968307 G/A cg12889195 chr2:113992843 PAX8;LOC440839;LOC654433 0.51 5.95 0.31 7.01e-9 Renal function-related traits (BUN); CRC cis rs7020830 0.823 rs13285624 chr9:37129496 T/G cg14294708 chr9:37120828 ZCCHC7 1.22 28.25 0.84 5.77e-90 Schizophrenia; CRC cis rs12325245 0.536 rs12931051 chr16:58626534 C/T cg19824325 chr16:58548873 SETD6 1.0 6.84 0.35 3.87e-11 Schizophrenia; CRC cis rs2839186 0.814 rs12482209 chr21:47664275 C/G cg05896524 chr21:47604654 C21orf56 -0.47 -7.19 -0.37 4.44e-12 Testicular germ cell tumor; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg04830409 chr12:64615927 C12orf66 0.54 6.92 0.36 2.31e-11 Thyroid stimulating hormone; CRC cis rs4665809 0.590 rs7586047 chr2:26447335 A/G cg22920501 chr2:26401640 FAM59B -0.83 -11.96 -0.55 1.28e-27 Gut microbiome composition (summer); CRC cis rs2204008 0.623 rs1663281 chr12:38120936 A/G cg13010199 chr12:38710504 ALG10B -0.42 -6.13 -0.32 2.53e-9 Bladder cancer; CRC cis rs853679 0.517 rs9295758 chr6:28120663 C/G cg02683197 chr6:28174875 NA 0.87 10.73 0.51 3.25e-23 Depression; CRC cis rs1005277 0.579 rs2474574 chr10:38387295 C/T cg25427524 chr10:38739819 LOC399744 -0.77 -13.64 -0.6 6.85e-34 Extrinsic epigenetic age acceleration; CRC cis rs9381040 0.610 rs9381028 chr6:41025081 C/A cg09580153 chr6:41068724 NFYA;LOC221442 -0.42 -6.12 -0.32 2.71e-9 Alzheimer's disease (late onset); CRC cis rs7618501 0.633 rs35065728 chr3:50009176 T/C cg05623727 chr3:50126028 RBM5 0.45 7.62 0.39 2.77e-13 Intelligence (multi-trait analysis); CRC cis rs10911363 0.659 rs2275676 chr1:183430822 C/G cg09173681 chr1:183549694 NCF2 -0.74 -10.15 -0.49 3e-21 Systemic lupus erythematosus; CRC cis rs7584330 0.518 rs11903073 chr2:238432766 C/T cg14458575 chr2:238380390 NA 0.53 7.01 0.36 1.33e-11 Prostate cancer; CRC cis rs992157 1.000 rs4674280 chr2:219141458 C/G cg20019365 chr2:219134978 PNKD;AAMP -0.39 -5.92 -0.31 8.16e-9 Colorectal cancer; CRC cis rs11764590 0.694 rs2056477 chr7:2079744 G/C cg21155852 chr7:2048760 MAD1L1 -0.4 -6.04 -0.32 4.21e-9 Neuroticism; CRC cis rs4803468 1.000 rs2569754 chr19:41936734 A/G cg09537434 chr19:41945824 ATP5SL -0.97 -18.25 -0.71 6.72e-52 Height; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg13546538 chr9:111754815 CTNNAL1 -0.37 -6.0 -0.31 5.1e-9 Liver disease severity in Alagille syndrome; CRC cis rs9925964 0.933 rs4889530 chr16:31065918 T/A cg03418659 chr16:31128414 MYST1 0.46 6.83 0.35 4.13e-11 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs79349575 0.783 rs962272 chr17:46978283 A/G cg00947319 chr17:47005597 UBE2Z -0.34 -5.93 -0.31 7.7e-9 Type 2 diabetes; CRC cis rs13096760 1 rs13096760 chr3:49476806 T/C cg03060546 chr3:49711283 APEH 0.69 11.87 0.55 2.67e-27 Intelligence (multi-trait analysis); CRC cis rs13217239 0.574 rs9366680 chr6:27006123 A/T cg05192639 chr6:26864778 GUSBL1 0.33 6.35 0.33 7.19e-10 Schizophrenia; CRC cis rs10078 0.571 rs890977 chr5:476910 T/C cg08916839 chr5:415575 AHRR 0.81 7.93 0.4 3.5e-14 Fat distribution (HIV); CRC trans rs9291683 0.609 rs7678012 chr4:9993772 T/C cg26043149 chr18:55253948 FECH 0.51 8.09 0.41 1.18e-14 Bone mineral density; CRC cis rs4862750 0.872 rs13110072 chr4:187878524 A/G cg03647317 chr4:187891568 NA -0.54 -10.06 -0.49 6.03e-21 Lobe attachment (rater-scored or self-reported); CRC cis rs6594499 0.872 rs1379298 chr5:110435726 T/C cg04022379 chr5:110408740 TSLP 0.46 7.04 0.36 1.11e-11 Allergic disease (asthma, hay fever or eczema); CRC cis rs875971 1.000 rs778685 chr7:65836176 G/T cg18912574 chr7:65842487 NCRNA00174 0.36 6.18 0.32 1.88e-9 Aortic root size; CRC trans rs2274459 0.673 rs35328423 chr6:33731592 C/T cg06457534 chr11:91536479 NA 0.35 6.13 0.32 2.47e-9 Obesity (extreme); CRC cis rs951366 0.789 rs864783 chr1:205711974 T/C cg14893161 chr1:205819251 PM20D1 0.83 13.04 0.58 1.32e-31 Menarche (age at onset); CRC cis rs3091242 0.902 rs36003018 chr1:25784318 A/G cg27572855 chr1:25598939 RHD -0.35 -6.08 -0.32 3.31e-9 Erythrocyte sedimentation rate; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg01802975 chr1:67519155 SLC35D1 0.43 7.01 0.36 1.37e-11 Liver disease severity in Alagille syndrome; CRC cis rs2976388 0.609 rs2376491 chr8:143790934 G/A cg24046110 chr8:143859143 LYNX1 0.46 8.05 0.41 1.5e-14 Urinary tract infection frequency; CRC cis rs8180040 0.966 rs11710322 chr3:47331136 C/T cg10298567 chr3:47292165 KIF9 0.44 7.0 0.36 1.41e-11 Colorectal cancer; CRC cis rs4481887 0.504 rs7529247 chr1:248359877 C/T cg00666640 chr1:248458726 OR2T12 0.44 7.07 0.36 9.39e-12 Common traits (Other); CRC trans rs56114371 0.777 rs200483 chr6:27774824 C/T cg16898833 chr6:26189333 HIST1H4D 0.7 6.23 0.32 1.42e-9 Breast cancer; CRC cis rs7916697 0.891 rs7897809 chr10:70000293 A/G cg06988349 chr10:69991859 ATOH7 0.32 5.95 0.31 6.76e-9 Optic disc area; CRC cis rs72945132 0.882 rs6592554 chr11:70226040 G/A cg14191688 chr11:70257035 CTTN 0.4 5.67 0.3 3.1e-8 Coronary artery disease; CRC cis rs6743376 0.556 rs2515396 chr2:113819175 G/A cg24553058 chr2:113831203 IL1F10 0.42 6.94 0.36 2.13e-11 Inflammatory biomarkers; CRC cis rs78663649 0.614 rs76626935 chr19:16581375 T/C cg10248733 chr19:16607483 C19orf44;CALR3 -0.87 -5.94 -0.31 7.14e-9 White blood cell count; CRC cis rs2860975 0.905 rs10882516 chr10:96791217 A/C cg09036531 chr10:96991505 NA -0.47 -6.27 -0.33 1.15e-9 Immune response to smallpox vaccine (IL-6); CRC trans rs9329221 0.537 rs6986911 chr8:9978523 C/T cg06636001 chr8:8085503 FLJ10661 0.46 6.72 0.35 7.94e-11 Neuroticism; CRC cis rs968567 0.705 rs174575 chr11:61602003 C/G cg06781209 chr11:61594997 FADS2 -0.52 -7.47 -0.38 7.38e-13 Blood metabolite levels;Rheumatoid arthritis;Vitiligo;Glycerophospholipid levels; CRC cis rs1891275 0.550 rs4933694 chr10:93499213 C/T cg07889827 chr10:93443413 NA -0.39 -6.58 -0.34 1.82e-10 Intelligence (multi-trait analysis); CRC cis rs9858542 1.000 rs13085791 chr3:49721798 C/A cg03060546 chr3:49711283 APEH -0.5 -6.79 -0.35 5.18e-11 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs939574 1.000 rs2293078 chr2:220100683 C/G cg00496455 chr2:220118770 TUBA4A;TUBA4B 0.89 8.98 0.44 2.2e-17 Platelet distribution width; CRC cis rs514406 0.683 rs6588440 chr1:53209587 C/T cg25767906 chr1:53392781 SCP2 0.42 6.67 0.34 1.11e-10 Monocyte count; CRC cis rs7927592 0.913 rs7107622 chr11:68374183 T/C cg16797656 chr11:68205561 LRP5 0.37 6.01 0.31 5.06e-9 Total body bone mineral density; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg02679291 chr19:48248902 GLTSCR2 0.41 6.12 0.32 2.64e-9 Intelligence (multi-trait analysis); CRC cis rs6951245 1.000 rs74369356 chr7:1071711 T/C cg03188948 chr7:1209495 NA 0.63 6.52 0.34 2.64e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs910316 0.967 rs119076 chr14:75572419 G/T cg11812906 chr14:75593930 NEK9 -0.57 -9.14 -0.45 6.56e-18 Height; CRC cis rs2717559 0.522 rs10956987 chr8:143886613 T/C cg24046110 chr8:143859143 LYNX1 -0.78 -14.68 -0.63 7.29e-38 Urinary tract infection frequency; CRC cis rs12325245 0.536 rs35432891 chr16:58561966 G/A cg01472538 chr16:58549086 SETD6 1.03 6.64 0.34 1.3100000000000001e-10 Schizophrenia; CRC trans rs35365539 1 rs35365539 chr3:49794347 A/AC cg21659725 chr3:3221576 CRBN -0.91 -17.8 -0.7 4.19e-50 Blood protein levels; CRC cis rs6696846 0.691 rs11240370 chr1:205118336 T/G cg03948781 chr1:205179583 DSTYK 0.41 5.77 0.3 1.88e-8 Red blood cell count; CRC cis rs7312933 0.701 rs10880260 chr12:42561398 A/G cg19980929 chr12:42632907 YAF2 0.44 6.53 0.34 2.47e-10 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CRC cis rs13064447 0.870 rs7631468 chr3:12754997 A/G cg07775309 chr3:12595852 NA -0.37 -5.9 -0.31 9.12e-9 Major depression and alcohol dependence; CRC cis rs11105298 0.891 rs11105319 chr12:89927177 G/A cg08166232 chr12:89918718 WDR51B;GALNT4 -0.61 -7.48 -0.38 6.87e-13 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; CRC cis rs11758351 0.660 rs113205297 chr6:26210808 A/C cg22723502 chr6:26240528 HIST1H4F -0.37 -6.19 -0.32 1.78e-9 Gout;Renal underexcretion gout; CRC cis rs7945718 0.591 rs7937898 chr11:12703561 G/T cg25843174 chr11:12811716 TEAD1 -0.41 -7.64 -0.39 2.47e-13 Educational attainment (years of education); CRC cis rs1552244 1.000 rs33917318 chr3:10067797 T/C cg08888203 chr3:10149979 C3orf24 0.69 9.65 0.47 1.46e-19 Alzheimer's disease; CRC cis rs6754311 0.773 rs632632 chr2:136638216 A/G cg25344623 chr2:136566232 LCT -0.31 -5.68 -0.3 3e-8 Mosquito bite size; CRC cis rs4689388 0.926 rs9998519 chr4:6292909 C/T cg14416269 chr4:6271139 WFS1 0.4 6.63 0.34 1.34e-10 Type 2 diabetes and other traits;Type 2 diabetes; CRC cis rs929354 0.772 rs7778193 chr7:156980087 C/T cg16102536 chr7:156981717 UBE3C 0.39 6.58 0.34 1.85e-10 Body mass index; CRC cis rs875971 0.825 rs10281499 chr7:66048966 A/G cg18876405 chr7:65276391 NA -0.53 -8.55 -0.43 4.8e-16 Aortic root size; CRC cis rs611744 0.506 rs13280454 chr8:109263240 A/G cg21045802 chr8:109455806 TTC35 0.42 6.6 0.34 1.66e-10 Dupuytren's disease; CRC cis rs28386778 0.897 rs4638645 chr17:61828349 T/C cg25654072 chr17:61904446 PSMC5;FTSJ3 0.73 11.3 0.53 2.96e-25 Prudent dietary pattern; CRC trans rs853679 0.546 rs200948 chr6:27835272 T/C cg06606381 chr12:133084897 FBRSL1 -0.77 -6.6 -0.34 1.66e-10 Depression; CRC cis rs6495367 1.000 rs28412916 chr15:79378167 A/C cg17916960 chr15:79447300 NA 0.36 5.9 0.31 8.8e-9 Spherical equivalent (joint analysis main effects and education interaction); CRC cis rs11098499 0.954 rs28685688 chr4:120420334 T/C cg24375607 chr4:120327624 NA 0.48 7.34 0.38 1.69e-12 Corneal astigmatism; CRC cis rs9291683 0.595 rs13145442 chr4:10037261 C/A cg11266682 chr4:10021025 SLC2A9 0.53 11.08 0.52 1.85e-24 Bone mineral density; CRC cis rs698833 0.926 rs786624 chr2:44604941 C/T cg04920474 chr2:44395004 PPM1B -0.42 -6.11 -0.32 2.8e-9 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; CRC cis rs2836950 0.501 rs62223052 chr21:40708702 A/C cg06238570 chr21:40685208 BRWD1 -0.59 -8.27 -0.41 3.42e-15 Menarche (age at onset); CRC cis rs1008375 0.902 rs6844984 chr4:17651304 C/G cg16339924 chr4:17578868 LAP3 0.54 7.27 0.37 2.62e-12 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs2625529 0.775 rs4777466 chr15:72136872 C/T cg16672083 chr15:72433130 SENP8 -0.45 -6.65 -0.34 1.23e-10 Red blood cell count; CRC cis rs1552244 0.608 rs7615408 chr3:10000186 A/G cg18598329 chr3:10140678 FANCD2;C3orf24 -0.53 -7.68 -0.39 1.85e-13 Alzheimer's disease; CRC trans rs1945213 0.694 rs34537090 chr11:55843285 G/C cg03929089 chr4:120376271 NA 0.53 6.13 0.32 2.49e-9 Acute lymphoblastic leukemia (childhood); CRC cis rs11122272 0.701 rs743120 chr1:231531232 C/T cg06096015 chr1:231504339 EGLN1 0.41 6.19 0.32 1.8e-9 Hemoglobin concentration; CRC cis rs2411233 1.000 rs10851374 chr15:39270049 C/A cg23129342 chr15:39283510 NA 0.31 5.95 0.31 7.02e-9 Platelet count; CRC cis rs2439831 1.000 rs9920763 chr15:43760508 T/G cg02155558 chr15:43621948 ADAL;LCMT2 0.85 8.34 0.42 2.02e-15 Lung cancer in ever smokers; CRC cis rs6942756 1.000 rs67520056 chr7:128982075 A/G cg02491457 chr7:128862824 NA -0.76 -10.25 -0.49 1.46e-21 White matter hyperintensity burden; CRC cis rs1509123 0.609 rs7224971 chr17:6713999 A/T cg12642237 chr17:6703447 TEKT1 0.57 5.88 0.31 1.03e-8 Blood metabolite levels; CRC cis rs9916302 0.706 rs7503377 chr17:37708841 A/G cg07936489 chr17:37558343 FBXL20 -0.9 -11.26 -0.53 4.1e-25 Glomerular filtration rate (creatinine); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg23113715 chr22:25800663 NA 0.51 8.0 0.4 2.14e-14 Liver disease severity in Alagille syndrome; CRC cis rs2836974 0.627 rs8127986 chr21:40687211 A/T cg17971929 chr21:40555470 PSMG1 -0.65 -9.72 -0.47 8.74e-20 Cognitive function; CRC trans rs7944735 0.607 rs34895872 chr11:48021778 A/G cg15704280 chr7:45808275 SEPT13 0.56 7.4 0.38 1.13e-12 Intraocular pressure; CRC cis rs185694 1.000 rs595449 chr13:30896852 T/C cg07600127 chr13:30881527 KATNAL1 -0.56 -5.97 -0.31 5.99e-9 Antineutrophil cytoplasmic antibody-associated vasculitis; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg16371860 chr21:42880448 TMPRSS2 0.42 6.92 0.36 2.4e-11 Liver disease severity in Alagille syndrome; CRC trans rs208520 0.690 rs207102 chr6:66795671 G/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.08 -15.36 -0.65 1.56e-40 Exhaled nitric oxide output; CRC cis rs6088590 1.000 rs910870 chr20:33292893 T/C cg08999081 chr20:33150536 PIGU 0.47 7.83 0.4 6.85e-14 Coronary artery disease; CRC cis rs2066819 1.000 rs35526714 chr12:56634639 G/C cg26714650 chr12:56694279 CS -1.46 -11.65 -0.54 1.76e-26 Psoriasis vulgaris; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg20189904 chr20:35974307 SRC -0.42 -6.06 -0.32 3.64e-9 Myopia (pathological); CRC cis rs654950 0.653 rs2810568 chr1:42054247 A/G cg06885757 chr1:42089581 HIVEP3 -0.55 -9.32 -0.46 1.74e-18 Airway imaging phenotypes; CRC cis rs394563 0.625 rs394526 chr6:149796975 T/G cg11245181 chr6:149772854 ZC3H12D -0.44 -6.91 -0.36 2.49e-11 Dupuytren's disease; CRC cis rs11676348 0.967 rs4672873 chr2:219005210 A/G cg04731861 chr2:219085781 ARPC2 0.27 5.69 0.3 2.83e-8 Ulcerative colitis; CRC cis rs2380220 0.872 rs2613528 chr6:95939437 C/G cg04719120 chr6:96025338 MANEA -0.53 -5.81 -0.31 1.45e-8 Behavioural disinhibition (generation interaction); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg19436567 chr6:157099375 ARID1B 0.47 6.55 0.34 2.17e-10 Response to antipsychotic treatment; CRC cis rs4713118 0.955 rs9393848 chr6:27688369 C/T cg19041857 chr6:27730383 NA -0.43 -6.11 -0.32 2.74e-9 Parkinson's disease; CRC cis rs9660992 0.542 rs17345153 chr1:205179997 A/G cg00857998 chr1:205179979 DSTYK 0.49 6.69 0.35 9.71e-11 Mean corpuscular volume;Mean platelet volume; CRC cis rs4478858 0.735 rs1566964 chr1:31792794 C/A cg00250761 chr1:31883323 NA -0.44 -8.42 -0.42 1.16e-15 Alcohol dependence; CRC cis rs3806843 0.576 rs246049 chr5:140327590 T/G cg19875535 chr5:140030758 IK 0.39 6.02 0.31 4.67e-9 Depressive symptoms (multi-trait analysis); CRC cis rs853679 0.628 rs9368560 chr6:28159960 T/C cg02683197 chr6:28174875 NA 0.84 11.1 0.52 1.64e-24 Depression; CRC cis rs6121246 0.529 rs6060134 chr20:30176794 A/G cg18721089 chr20:30220636 NA -0.53 -7.92 -0.4 3.76e-14 Mean corpuscular hemoglobin; CRC cis rs796364 1.000 rs281771 chr2:200812202 A/C cg23649088 chr2:200775458 C2orf69 -0.52 -5.73 -0.3 2.25e-8 Schizophrenia; CRC cis rs875971 0.862 rs7796162 chr7:65745758 T/C cg18876405 chr7:65276391 NA -0.53 -8.43 -0.42 1.1e-15 Aortic root size; CRC trans rs925098 0.577 rs2724470 chr4:17996046 A/G ch.14.35531994F chr14:36462243 NA -0.47 -7.03 -0.36 1.21e-11 Birth weight;Height; CRC cis rs10504229 0.593 rs17192845 chr8:58053339 C/T cg22535103 chr8:58192502 C8orf71 -0.8 -8.75 -0.43 1.12e-16 Developmental language disorder (linguistic errors); CRC cis rs6912958 1.000 rs9450701 chr6:88173167 T/C cg08069147 chr6:88032118 GJB7;C6orf162 -0.59 -8.91 -0.44 3.64e-17 Monocyte percentage of white cells; CRC cis rs1950626 0.833 rs12891189 chr14:101415523 C/T cg02351406 chr14:101447389 SNORD114-20;SNORD114-21 0.95 16.09 0.66 2.16e-43 Pelvic organ prolapse (moderate/severe); CRC cis rs6540559 0.673 rs11803382 chr1:209986426 G/A cg23283495 chr1:209979779 IRF6 0.46 6.53 0.34 2.43e-10 Cleft lip with or without cleft palate; CRC cis rs1707322 0.716 rs10890342 chr1:46157087 C/T cg03146154 chr1:46216737 IPP 0.67 9.73 0.47 7.77e-20 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC trans rs17685 0.671 rs10274404 chr7:75706634 G/A cg19862616 chr7:65841803 NCRNA00174 1.0 18.41 0.71 1.64e-52 Coffee consumption;Coffee consumption (cups per day); CRC cis rs7666738 0.791 rs1830231 chr4:99026185 A/C cg05340658 chr4:99064831 C4orf37 0.6 9.19 0.45 4.67e-18 Colonoscopy-negative controls vs population controls; CRC cis rs870825 0.698 rs28412823 chr4:185638829 T/C cg04058563 chr4:185651563 MLF1IP 0.73 9.56 0.47 2.93e-19 Blood protein levels; CRC cis rs3859192 0.599 rs2227319 chr17:38170845 G/A cg17344932 chr17:38183730 MED24;SNORD124 0.85 16.6 0.68 2.12e-45 White blood cell count; CRC cis rs7927771 0.864 rs2293580 chr11:47440283 T/A cg05585544 chr11:47624801 NA 0.47 8.52 0.43 5.86e-16 Subjective well-being; CRC cis rs9487051 0.837 rs2356817 chr6:109642675 G/A cg12927641 chr6:109611667 NA -0.35 -6.22 -0.32 1.49e-9 Reticulocyte fraction of red cells; CRC cis rs10464366 0.614 rs62442213 chr7:39146933 C/T cg18850127 chr7:39170497 POU6F2 0.57 7.6 0.39 3.12e-13 IgG glycosylation; CRC cis rs2386661 0.826 rs1317517 chr10:5672580 T/G cg26603656 chr10:5671107 NA 0.54 8.91 0.44 3.52e-17 Breast cancer; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg04597389 chr17:79935740 ASPSCR1 0.43 6.02 0.31 4.68e-9 Anxiety disorder; CRC cis rs66573146 1.000 rs6812771 chr4:6964048 G/A cg00086871 chr4:6988644 TBC1D14 1.01 7.58 0.39 3.49e-13 Granulocyte percentage of myeloid white cells; CRC cis rs9649213 0.502 rs6465680 chr7:98005778 A/G cg00277769 chr7:97922759 BAIAP2L1 -0.61 -10.64 -0.51 6.41e-23 Prostate cancer (SNP x SNP interaction); CRC cis rs6840360 0.615 rs2406973 chr4:152608339 G/T cg09659197 chr4:152720779 NA -0.39 -8.0 -0.4 2.17e-14 Intelligence (multi-trait analysis); CRC cis rs3096299 0.658 rs4291902 chr16:89560315 G/C cg01788221 chr16:89496183 ANKRD11 -0.38 -5.61 -0.3 4.29e-8 Multiple myeloma (IgH translocation); CRC cis rs6060717 0.610 rs1891151 chr20:34612726 G/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.43 -6.33 -0.33 8.22e-10 Hip circumference adjusted for BMI; CRC cis rs10540 1.000 rs61876326 chr11:467368 A/G cg03576123 chr11:487126 PTDSS2 -1.01 -10.5 -0.5 2e-22 Body mass index; CRC cis rs8103278 1.000 rs7258283 chr19:46335511 C/T cg11657440 chr19:46296263 DMWD -0.51 -7.1 -0.36 7.8e-12 Coronary artery disease; CRC cis rs11122272 0.735 rs2256908 chr1:231506557 G/A cg06096015 chr1:231504339 EGLN1 0.39 5.84 0.31 1.23e-8 Hemoglobin concentration; CRC cis rs7659604 0.846 rs60340409 chr4:122666355 G/C cg20573242 chr4:122745356 CCNA2 0.43 6.31 0.33 8.9e-10 Type 2 diabetes; CRC cis rs4819052 0.765 rs2838852 chr21:46677037 C/A cg19498844 chr21:46707878 POFUT2;LOC642852 0.77 10.85 0.51 1.16e-23 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs853679 0.517 rs9468298 chr6:28122345 A/G cg15845792 chr6:28175446 NA 1.04 13.89 0.61 7.67e-35 Depression; CRC cis rs8180040 0.726 rs6774733 chr3:46991241 G/A cg02527881 chr3:46936655 PTH1R -0.43 -8.06 -0.41 1.4e-14 Colorectal cancer; CRC cis rs4766646 0.619 rs10850883 chr12:110292513 G/A cg01252219 chr12:110302105 GLTP 0.4 6.17 0.32 2.06e-9 Metabolite levels (MHPG); CRC cis rs12142240 0.698 rs1475390 chr1:46816340 A/G cg00530320 chr1:46809349 NSUN4 0.57 7.75 0.39 1.19e-13 Menopause (age at onset); CRC cis rs7149337 0.869 rs10137445 chr14:51694416 G/A cg18683604 chr14:51561293 TRIM9 0.29 5.66 0.3 3.32e-8 Cancer; CRC cis rs9894429 1.000 rs9748176 chr17:79584043 C/G cg21028142 chr17:79581711 NPLOC4 0.38 8.26 0.41 3.64e-15 Eye color traits; CRC cis rs736408 0.522 rs6445535 chr3:52771468 T/C cg11645453 chr3:52864694 ITIH4 0.36 6.48 0.34 3.31e-10 Bipolar disorder; CRC cis rs9902453 0.765 rs2628167 chr17:28064498 C/T cg26525008 chr17:28256777 EFCAB5;SSH2 -0.71 -11.97 -0.55 1.2100000000000001e-27 Coffee consumption (cups per day); CRC cis rs1580019 0.883 rs6945294 chr7:32472099 G/A cg07520158 chr7:32535189 LSM5;AVL9 0.45 6.12 0.32 2.59e-9 Cognitive ability; CRC cis rs7098414 0.511 rs7916349 chr10:82152638 G/A cg00277334 chr10:82204260 NA -0.48 -7.74 -0.39 1.23e-13 Post bronchodilator FEV1; CRC cis rs4731207 0.596 rs1011722 chr7:124605207 A/C cg23710748 chr7:124431027 NA -0.38 -6.08 -0.32 3.35e-9 Cutaneous malignant melanoma; CRC cis rs9858542 0.537 rs2304442 chr3:49322027 A/T cg00383909 chr3:49044727 WDR6 -0.65 -7.05 -0.36 1.08e-11 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs860295 0.812 rs2297775 chr1:155735012 C/T cg02153340 chr1:155202674 NA 0.54 6.66 0.34 1.15e-10 Body mass index; CRC cis rs7312933 0.618 rs12366848 chr12:42682215 A/G cg19980929 chr12:42632907 YAF2 0.45 6.76 0.35 6.2e-11 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CRC cis rs7762018 0.607 rs75438963 chr6:170047695 G/A cg24289452 chr6:170231220 NA -0.94 -7.59 -0.39 3.43e-13 Thiazide-induced adverse metabolic effects in hypertensive patients; CRC cis rs9894429 0.752 rs6565610 chr17:79592652 A/G cg21984481 chr17:79567631 NPLOC4 -0.58 -11.19 -0.52 7.81e-25 Eye color traits; CRC cis rs7927771 0.524 rs7929725 chr11:47881740 A/G cg20307385 chr11:47447363 PSMC3 0.45 6.62 0.34 1.48e-10 Subjective well-being; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg11235871 chr3:49142143 QARS 0.46 6.55 0.34 2.2e-10 Response to antipsychotic treatment; CRC cis rs853679 0.517 rs1340004 chr6:28103691 C/T cg02631126 chr6:28058918 ZSCAN12L1 0.28 5.74 0.3 2.1e-8 Depression; CRC cis rs2153535 0.580 rs7742794 chr6:8459723 C/A cg07606381 chr6:8435919 SLC35B3 0.69 11.15 0.52 1.04e-24 Motion sickness; CRC trans rs944990 0.595 rs10123378 chr9:96375217 C/T cg03044510 chr21:27107978 ATP5J;GABPA 0.42 6.33 0.33 8.1e-10 Body mass index; CRC cis rs875971 0.862 rs6460306 chr7:66060793 T/C cg18252515 chr7:66147081 NA 0.43 6.16 0.32 2.14e-9 Aortic root size; CRC cis rs7173389 1.000 rs4489968 chr15:73665506 T/G cg01796676 chr15:73680284 NA 0.51 6.76 0.35 6.43e-11 Resting heart rate; CRC cis rs9926296 0.744 rs164748 chr16:89708292 C/G cg01097406 chr16:89675127 NA 0.5 9.19 0.45 4.49e-18 Vitiligo; CRC cis rs9457247 0.515 rs2757039 chr6:167370353 G/T cg23791538 chr6:167370224 RNASET2 0.58 9.42 0.46 8.02e-19 Crohn's disease; CRC cis rs12347191 0.500 rs907578 chr9:100622883 A/G cg13688889 chr9:100608707 NA -0.47 -5.92 -0.31 8.1e-9 Orofacial clefts; CRC cis rs8177253 0.898 rs8177258 chr3:133480387 C/A cg16262614 chr3:133464971 TF 0.34 6.04 0.32 4.19e-9 Iron status biomarkers; CRC cis rs898097 0.627 rs3785514 chr17:80888905 A/G cg15369054 chr17:80825471 TBCD -0.52 -8.09 -0.41 1.16e-14 Breast cancer; CRC trans rs11343 0.675 rs7359333 chr16:19262344 A/T cg02633924 chr17:75315563 SEPT9 -0.49 -6.3 -0.33 9.75e-10 Parkinson's disease; CRC trans rs10506458 0.834 rs73127067 chr12:63390333 G/T cg03429785 chr15:59498649 MYO1E;LDHAL6B -1.46 -21.13 -0.76 3.29e-63 Hemostatic factors and hematological phenotypes; CRC trans rs656319 0.564 rs11776035 chr8:10071527 A/G cg06636001 chr8:8085503 FLJ10661 -0.52 -7.52 -0.38 5.18e-13 Myopia (pathological); CRC cis rs500492 0.542 rs449295 chr16:1074443 G/A cg03495660 chr16:1074500 NA 0.43 5.68 0.3 2.95e-8 Polycystic ovary syndrome; CRC cis rs7727544 1.000 rs7727544 chr5:131590534 C/T cg11843238 chr5:131593191 PDLIM4 0.36 6.97 0.36 1.77e-11 Blood metabolite levels; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg18405786 chr19:18746985 KLHL26 0.43 6.16 0.32 2.06e-9 Response to antipsychotic treatment; CRC cis rs6502050 0.842 rs9894129 chr17:80075700 A/G cg11859384 chr17:80120422 CCDC57 0.37 5.82 0.31 1.43e-8 Life satisfaction; CRC cis rs7618915 0.571 rs34954168 chr3:52612159 C/T cg11645453 chr3:52864694 ITIH4 0.34 5.92 0.31 8.26e-9 Bipolar disorder; CRC cis rs6570726 0.764 rs9322028 chr6:145895797 G/T cg13319975 chr6:146136371 FBXO30 -0.42 -6.22 -0.32 1.53e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs769267 0.965 rs2315025 chr19:19426609 C/T cg02546618 chr19:19431379 KIAA0892;SF4 0.48 6.67 0.35 1.06e-10 Tonsillectomy; CRC cis rs977987 0.966 rs6564261 chr16:75492242 C/T cg03315344 chr16:75512273 CHST6 0.61 10.29 0.49 1.04e-21 Dupuytren's disease; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg14850771 chr21:34775459 IFNGR2 0.39 6.11 0.32 2.85e-9 Liver disease severity in Alagille syndrome; CRC cis rs7647973 0.961 rs7638750 chr3:49452957 A/T cg07690219 chr3:49449608 TCTA;RHOA 0.51 5.75 0.3 2.09e-8 Menarche (age at onset); CRC cis rs7618915 0.501 rs2336149 chr3:52692124 G/A cg08222913 chr3:52553049 STAB1 -0.34 -6.26 -0.33 1.22e-9 Bipolar disorder; CRC cis rs796364 0.901 rs35572201 chr2:201035093 T/C cg23649088 chr2:200775458 C2orf69 -0.57 -6.11 -0.32 2.86e-9 Schizophrenia; CRC cis rs7209700 0.662 rs8074094 chr17:45348021 T/C cg17185639 chr17:45330862 ITGB3 0.37 6.0 0.31 5.28e-9 IgG glycosylation; CRC cis rs4713118 0.868 rs35069907 chr6:27746692 T/C cg02683197 chr6:28174875 NA 0.65 7.09 0.36 8.01e-12 Parkinson's disease; CRC cis rs6952808 0.825 rs34922657 chr7:1938655 C/T cg02951883 chr7:2050386 MAD1L1 -0.7 -11.12 -0.52 1.36e-24 Bipolar disorder and schizophrenia; CRC trans rs1005277 0.579 rs2474571 chr10:38384639 T/G cg11292332 chr7:45801988 SEPT13 -0.35 -6.27 -0.33 1.11e-9 Extrinsic epigenetic age acceleration; CRC trans rs6550704 0.687 rs9865314 chr3:22634337 A/G cg08402873 chr20:10653164 JAG1 -0.48 -7.17 -0.37 4.94e-12 Daytime sleep phenotypes; CRC cis rs3820068 0.603 rs6660234 chr1:15962590 T/C cg27534772 chr1:16042836 PLEKHM2 0.53 10.38 0.5 4.9e-22 Systolic blood pressure; CRC cis rs7258465 1.000 rs10405636 chr19:18538742 A/C cg10790698 chr19:18539756 SSBP4 -0.47 -8.79 -0.44 8.33e-17 Breast cancer; CRC cis rs4713118 0.513 rs200971 chr6:27858904 C/T cg26587870 chr6:27730563 NA -0.43 -6.47 -0.34 3.49e-10 Parkinson's disease; CRC cis rs2032447 0.670 rs198845 chr6:26107790 A/C cg03264133 chr6:25882463 NA -0.43 -5.86 -0.31 1.1e-8 Intelligence (multi-trait analysis); CRC cis rs875971 1.000 rs875971 chr7:65617595 A/G cg18912574 chr7:65842487 NCRNA00174 -0.37 -6.42 -0.33 4.89e-10 Aortic root size; CRC cis rs9463078 0.753 rs1329716 chr6:44953758 C/T cg25276700 chr6:44698697 NA -0.28 -6.99 -0.36 1.55e-11 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; CRC cis rs9733 0.596 rs72702556 chr1:150680115 C/T cg10589385 chr1:150898437 SETDB1 0.28 5.96 0.31 6.66e-9 Tonsillectomy; CRC cis rs9467711 0.538 rs35934643 chr6:26355094 G/A cg14345882 chr6:26364793 BTN3A2 0.64 5.63 0.3 3.85e-8 Autism spectrum disorder or schizophrenia; CRC cis rs1506636 0.525 rs7812023 chr7:123260228 C/T cg03229431 chr7:123269106 ASB15 -0.76 -10.66 -0.51 5.5e-23 Plateletcrit;Platelet count; CRC cis rs10174077 0.874 rs11892439 chr2:152469858 T/A cg06191203 chr2:152266755 RIF1 -0.59 -8.41 -0.42 1.3e-15 Squamous cell lung carcinoma; CRC cis rs6964587 1.000 rs10235941 chr7:91587050 T/G cg17063962 chr7:91808500 NA 0.8 14.06 0.61 1.68e-35 Breast cancer; CRC cis rs7659604 1.000 rs7659604 chr4:122665514 A/G cg06713675 chr4:122721982 EXOSC9 0.38 6.12 0.32 2.69e-9 Type 2 diabetes; CRC cis rs951366 0.668 rs823154 chr1:205762406 C/T cg23034840 chr1:205782522 SLC41A1 0.54 7.57 0.39 3.71e-13 Menarche (age at onset); CRC cis rs7591163 0.883 rs11891398 chr2:228723357 C/T cg23807890 chr2:228736357 WDR69 -0.47 -6.56 -0.34 2.13e-10 Blood pressure; CRC cis rs9911578 0.935 rs6503878 chr17:56884581 T/G cg05425664 chr17:57184151 TRIM37 -0.48 -7.44 -0.38 8.69e-13 Intelligence (multi-trait analysis); CRC cis rs1707322 0.721 rs10890346 chr1:46223892 C/T cg06784218 chr1:46089804 CCDC17 -0.66 -12.49 -0.57 1.42e-29 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs2692947 0.655 rs60090597 chr2:96406266 G/A cg23100626 chr2:96804247 ASTL 0.26 6.91 0.36 2.58e-11 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; CRC cis rs7662987 0.517 rs1453874 chr4:100022724 G/A cg12011299 chr4:100065546 ADH4 0.49 9.27 0.46 2.46e-18 Smoking initiation; CRC cis rs2952156 0.920 rs1018246 chr17:37835240 C/T cg20243544 chr17:37824526 PNMT 0.56 9.01 0.45 1.67e-17 Asthma; CRC cis rs2354432 0.607 rs10453880 chr1:146693689 T/C cg25205988 chr1:146714368 CHD1L 1.11 9.6 0.47 2.06e-19 Mitochondrial DNA levels; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg10800280 chr6:36646508 CDKN1A 0.42 6.55 0.34 2.25e-10 Intelligence (multi-trait analysis); CRC cis rs3750965 0.575 rs3018691 chr11:68884543 C/T cg06818126 chr11:68850279 TPCN2 -0.43 -5.98 -0.31 5.82e-9 Hair color; CRC cis rs4332037 1.000 rs4332037 chr7:1950809 C/T cg21155852 chr7:2048760 MAD1L1 -0.45 -6.3 -0.33 9.55e-10 Bipolar disorder; CRC cis rs10927875 0.526 rs2179615 chr1:16282426 G/A cg21385522 chr1:16154831 NA -0.8 -9.21 -0.45 3.84e-18 Dilated cardiomyopathy; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg19557623 chr17:40540543 STAT3 0.46 6.42 0.33 4.81e-10 Response to antipsychotic treatment; CRC cis rs3806843 0.900 rs2261651 chr5:140136804 A/C cg19875535 chr5:140030758 IK -0.59 -9.64 -0.47 1.52e-19 Depressive symptoms (multi-trait analysis); CRC cis rs561341 1.000 rs111454793 chr17:30319267 T/C cg23018236 chr17:30244563 NA -0.67 -8.03 -0.4 1.78e-14 Hip circumference adjusted for BMI; CRC cis rs60843830 1.000 rs79716074 chr2:277003 A/G cg25945732 chr2:264204 ACP1;SH3YL1 0.72 11.67 0.54 1.43e-26 Spherical equivalent (joint analysis main effects and education interaction); CRC trans rs1814175 0.781 rs12286395 chr11:49954062 C/G cg11707556 chr5:10655725 ANKRD33B -0.42 -8.01 -0.4 2.02e-14 Height; CRC cis rs3764400 0.567 rs12939334 chr17:46302669 A/G cg10706073 chr17:46328419 SKAP1 -0.61 -6.65 -0.34 1.23e-10 Body mass index; CRC cis rs4665809 1.000 rs1560868 chr2:26281459 A/T cg25036284 chr2:26402008 FAM59B 0.47 6.18 0.32 1.91e-9 Gut microbiome composition (summer); CRC cis rs12681287 0.640 rs4961193 chr8:87486168 C/T cg27223183 chr8:87520930 FAM82B 0.5 7.34 0.38 1.71e-12 Caudate activity during reward; CRC cis rs9322193 0.847 rs12191643 chr6:149950048 C/T cg07701084 chr6:150067640 NUP43 0.6 8.82 0.44 6.75e-17 Lung cancer; CRC cis rs734999 0.588 rs2843402 chr1:2528682 T/C cg20673091 chr1:2541236 MMEL1 -0.36 -5.78 -0.3 1.76e-8 Ulcerative colitis; CRC cis rs4253772 0.591 rs6519993 chr22:46656479 A/G cg03482458 chr22:46692211 CN5H6.4;GTSE1 0.52 6.9 0.36 2.65e-11 LDL cholesterol;Cholesterol, total; CRC cis rs733592 0.507 rs3825403 chr12:48457159 G/A cg24011408 chr12:48396354 COL2A1 -0.46 -6.87 -0.35 3.32e-11 Plateletcrit; CRC cis rs2180341 0.842 rs9375492 chr6:127545492 C/T cg24812749 chr6:127587940 RNF146 -0.83 -10.44 -0.5 3.13e-22 Breast cancer; CRC cis rs10464059 0.700 rs6859159 chr5:179761769 C/T cg26918954 chr5:179728553 GFPT2 -0.45 -5.66 -0.3 3.35e-8 Parkinson's disease; CRC cis rs1577917 0.917 rs13196576 chr6:86534066 C/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.49 -6.58 -0.34 1.82e-10 Response to antipsychotic treatment; CRC cis rs853679 0.699 rs9468318 chr6:28209531 T/A cg03623178 chr6:28175578 NA 0.74 7.82 0.4 7.43e-14 Depression; CRC cis rs9309473 0.687 rs6710659 chr2:73607510 A/G cg20560298 chr2:73613845 ALMS1 -0.52 -7.32 -0.37 1.96e-12 Metabolite levels; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg00508499 chr22:38054505 PDXP 0.46 6.45 0.34 3.95e-10 Response to antipsychotic treatment; CRC trans rs9929218 1.000 rs12596061 chr16:68807828 A/G cg04657470 chr2:198365150 HSPE1;HSPD1 -0.83 -11.85 -0.55 3.21e-27 Colorectal cancer; CRC cis rs7772486 0.686 rs4896827 chr6:145953338 T/A cg05347473 chr6:146136440 FBXO30 0.37 5.67 0.3 3.19e-8 Lobe attachment (rater-scored or self-reported); CRC cis rs6502050 0.805 rs11651863 chr17:80084539 T/C cg19223190 chr17:80058835 NA -0.4 -6.27 -0.33 1.13e-9 Life satisfaction; CRC trans rs875971 0.545 rs801212 chr7:66015630 C/G cg02869306 chr7:64672164 INTS4L1 0.43 6.28 0.33 1.08e-9 Aortic root size; CRC cis rs11677416 1.000 rs4848300 chr2:113527906 T/C cg27083787 chr2:113543245 IL1A 0.45 6.48 0.34 3.38e-10 Response to antipsychotic treatment in schizophrenia (working memory); CRC cis rs17270561 0.636 rs2070642 chr6:25831212 G/A cg17691542 chr6:26056736 HIST1H1C 0.61 8.5 0.42 6.8e-16 Iron status biomarkers; CRC cis rs8014204 0.736 rs2111705 chr14:75261641 G/A cg03030879 chr14:75389066 RPS6KL1 -0.39 -6.13 -0.32 2.45e-9 Caffeine consumption; CRC cis rs6424115 0.830 rs1105 chr1:24200800 T/C cg10978503 chr1:24200527 CNR2 0.61 11.06 0.52 2.22e-24 Immature fraction of reticulocytes; CRC cis rs826838 0.967 rs7299170 chr12:38789536 G/A cg13010199 chr12:38710504 ALG10B 0.46 5.98 0.31 5.88e-9 Heart rate; CRC cis rs9649213 0.574 rs6961790 chr7:98007993 C/G cg24562669 chr7:97807699 LMTK2 0.42 6.87 0.35 3.15e-11 Prostate cancer (SNP x SNP interaction); CRC cis rs704795 0.775 rs4665975 chr2:27626017 A/T cg12000995 chr2:27665139 KRTCAP3 -0.3 -5.86 -0.31 1.13e-8 Menopause (age at onset); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg15993709 chr1:153631130 SNAPIN 0.46 6.43 0.33 4.44e-10 Response to antipsychotic treatment; CRC cis rs7202877 0.706 rs37602 chr16:75505046 C/T cg03315344 chr16:75512273 CHST6 -0.51 -6.3 -0.33 9.52e-10 Type 2 diabetes;Type 1 diabetes; CRC cis rs172166 0.637 rs1233708 chr6:28173219 C/T cg02683197 chr6:28174875 NA 0.69 9.8 0.48 4.69e-20 Cardiac Troponin-T levels; CRC cis rs1552244 1.000 rs33917318 chr3:10067797 T/C cg00166722 chr3:10149974 C3orf24 0.66 8.88 0.44 4.36e-17 Alzheimer's disease; CRC cis rs853679 0.760 rs967005 chr6:28210688 C/T cg15786705 chr6:28176104 NA 0.62 6.67 0.34 1.11e-10 Depression; CRC cis rs780096 0.526 rs704795 chr2:27716494 G/A cg21248554 chr2:27665150 KRTCAP3 -0.32 -7.55 -0.38 4.45e-13 Total body bone mineral density; CRC trans rs12599106 0.818 rs17723574 chr16:34602945 C/G cg01171360 chr6:293285 DUSP22 -0.44 -6.44 -0.33 4.35e-10 Menopause (age at onset); CRC cis rs1862618 0.853 rs832583 chr5:56178217 A/C cg24531977 chr5:56204891 C5orf35 -0.84 -10.92 -0.52 6.54e-24 Initial pursuit acceleration; CRC cis rs4474465 0.736 rs10899550 chr11:78256078 G/A cg27205649 chr11:78285834 NARS2 0.53 6.83 0.35 4.04e-11 Alzheimer's disease (survival time); CRC cis rs1707322 0.717 rs3014237 chr1:46090252 A/G cg06784218 chr1:46089804 CCDC17 -0.65 -11.65 -0.54 1.76e-26 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs2949837 0.581 rs2960437 chr7:45977352 G/A cg23193639 chr7:45961078 IGFBP3 0.4 6.62 0.34 1.5e-10 Sitting height ratio; CRC cis rs394563 0.690 rs237010 chr6:149758750 G/T cg03678062 chr6:149772716 ZC3H12D -0.38 -6.84 -0.35 3.88e-11 Dupuytren's disease; CRC cis rs8180040 0.800 rs56250009 chr3:47279497 G/C cg10298567 chr3:47292165 KIF9 0.41 6.38 0.33 5.89e-10 Colorectal cancer; CRC trans rs951252 0.504 rs11734405 chr4:146081096 C/T cg11855759 chr17:9548802 USP43 0.45 6.02 0.31 4.7e-9 Hip circumference; CRC cis rs7589728 1.000 rs75181745 chr2:88520408 C/T cg14558114 chr2:88469736 THNSL2 0.59 5.84 0.31 1.25e-8 Plasma clusterin levels; CRC cis rs2839186 0.619 rs55689527 chr21:47622727 A/G cg13012494 chr21:47604986 C21orf56 0.47 7.65 0.39 2.29e-13 Testicular germ cell tumor; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg01052666 chr22:22292729 PPM1F 0.46 6.81 0.35 4.77e-11 Response to antipsychotic treatment; CRC cis rs11758351 0.660 rs113205297 chr6:26210808 A/C cg01420254 chr6:26195488 NA 0.76 8.63 0.43 2.75e-16 Gout;Renal underexcretion gout; CRC cis rs8032158 0.896 rs8028559 chr15:56130909 A/G cg02198044 chr15:56286336 NEDD4 -0.37 -5.99 -0.31 5.49e-9 Keloid; CRC cis rs9649213 0.593 rs13232181 chr7:97935671 C/G cg00277769 chr7:97922759 BAIAP2L1 -0.58 -10.04 -0.48 7e-21 Prostate cancer (SNP x SNP interaction); CRC cis rs55823223 0.648 rs936394 chr17:73852008 C/A cg10935138 chr17:73851978 WBP2 0.65 7.85 0.4 5.8e-14 Psoriasis; CRC cis rs7618501 0.633 rs4688755 chr3:50064424 G/A cg05623727 chr3:50126028 RBM5 -0.45 -7.5 -0.38 5.92e-13 Intelligence (multi-trait analysis); CRC cis rs2565722 0.583 rs2465875 chr6:161298404 A/T cg03159191 chr6:161285451 NA -0.39 -5.95 -0.31 6.89e-9 Blood protein levels; CRC cis rs7264396 0.676 rs6060723 chr20:34549947 G/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.61 -9.86 -0.48 2.94e-20 Total cholesterol levels; CRC cis rs2386661 0.712 rs11259544 chr10:5646708 T/C cg26603656 chr10:5671107 NA 0.42 7.15 0.37 5.76e-12 Breast cancer; CRC trans rs3780486 0.757 rs10758189 chr9:33125804 A/G cg20290983 chr6:43655470 MRPS18A 1.14 25.93 0.82 1.68e-81 IgG glycosylation; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg26591144 chr17:1532201 SLC43A2 0.41 6.51 0.34 2.78e-10 Liver disease severity in Alagille syndrome; CRC cis rs2302190 0.769 rs8082396 chr17:56632193 C/T cg25885038 chr17:56607967 SEPT4 -0.51 -7.8 -0.4 8.2e-14 Vitamin D levels; CRC trans rs7267979 0.868 rs6138546 chr20:25216534 G/A cg17903999 chr18:56338584 MALT1 -0.4 -6.49 -0.34 3.16e-10 Liver enzyme levels (alkaline phosphatase); CRC cis rs965469 1.000 rs2281500 chr20:3262824 C/T cg25506879 chr20:3388711 C20orf194 -0.38 -5.67 -0.3 3.15e-8 IFN-related cytopenia; CRC cis rs11645898 0.872 rs72787093 chr16:72190766 C/T cg14768367 chr16:72042858 DHODH -0.59 -6.54 -0.34 2.32e-10 Blood protein levels; CRC cis rs3820928 0.933 rs1429267 chr2:227767593 G/C cg11843606 chr2:227700838 RHBDD1 -0.4 -5.74 -0.3 2.11e-8 Pulmonary function; CRC cis rs75920871 0.512 rs6589583 chr11:116863766 C/T cg01368799 chr11:117014884 PAFAH1B2 -0.4 -5.78 -0.3 1.71e-8 Subjective well-being; CRC cis rs9916302 0.904 rs4794807 chr17:37531718 T/A cg07936489 chr17:37558343 FBXL20 0.78 11.71 0.54 1.02e-26 Glomerular filtration rate (creatinine); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg20743544 chr7:32982957 RP9P 0.45 6.27 0.33 1.11e-9 Response to antipsychotic treatment; CRC cis rs35110281 0.511 rs2298562 chr21:45085236 A/G cg04455712 chr21:45112962 RRP1B 0.42 8.11 0.41 1.05e-14 Mean corpuscular volume; CRC cis rs6732160 0.588 rs11126392 chr2:73374454 A/G cg01422370 chr2:73384389 NA 0.37 5.78 0.3 1.74e-8 Intelligence (multi-trait analysis); CRC cis rs72781680 0.716 rs2712050 chr2:24059408 A/C cg08917208 chr2:24149416 ATAD2B 0.56 6.64 0.34 1.26e-10 Lymphocyte counts; CRC cis rs727563 0.608 rs2076200 chr22:41985956 G/T cg06634786 chr22:41940651 POLR3H -0.62 -6.38 -0.33 6.07e-10 Crohn's disease;Inflammatory bowel disease; CRC cis rs7615952 0.599 rs60847438 chr3:125746005 T/C cg04553112 chr3:125709451 NA -0.51 -5.71 -0.3 2.5e-8 Blood pressure (smoking interaction); CRC cis rs4728302 0.838 rs13231095 chr7:133604436 A/G cg03336402 chr7:133662267 EXOC4 -0.45 -6.52 -0.34 2.61e-10 Intelligence;Intelligence (multi-trait analysis); CRC cis rs853679 0.517 rs1947862 chr6:28105196 C/T cg23161317 chr6:28129485 ZNF389 0.53 6.52 0.34 2.71e-10 Depression; CRC cis rs853679 0.517 rs9348794 chr6:28117757 T/A cg25164649 chr6:28176230 NA 0.78 9.66 0.47 1.33e-19 Depression; CRC cis rs1005277 0.579 rs1780146 chr10:38517874 C/A cg25427524 chr10:38739819 LOC399744 -0.77 -13.58 -0.6 1.19e-33 Extrinsic epigenetic age acceleration; CRC cis rs57590327 0.504 rs11712243 chr3:81840674 T/G cg07356753 chr3:81810745 GBE1 -0.64 -8.66 -0.43 2.16e-16 Extraversion; CRC cis rs34779708 0.966 rs34776628 chr10:35426324 G/A cg03585969 chr10:35415529 CREM 0.55 7.41 0.38 1.08e-12 Inflammatory bowel disease;Crohn's disease; CRC cis rs9649213 0.613 rs10953256 chr7:97951886 G/C cg21770322 chr7:97807741 LMTK2 0.51 8.29 0.42 2.89e-15 Prostate cancer (SNP x SNP interaction); CRC cis rs10256972 0.641 rs12702017 chr7:1129413 C/T cg03188948 chr7:1209495 NA 0.44 6.21 0.32 1.61e-9 Longevity;Endometriosis; CRC cis rs1008375 1.000 rs2315560 chr4:17677305 C/G cg04450456 chr4:17643702 FAM184B 0.39 6.22 0.32 1.53e-9 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs9894429 1.000 rs9747349 chr17:79584297 C/T cg13777783 chr17:79615861 NA -0.3 -5.72 -0.3 2.44e-8 Eye color traits; CRC trans rs1455244 0.700 rs7229302 chr18:11508904 G/T cg26653293 chr17:1619494 C17orf91;WDR81 0.39 6.12 0.32 2.73e-9 Schizophrenia; CRC cis rs400736 1.000 rs400736 chr1:8078309 T/C cg25007680 chr1:8021821 PARK7 0.53 7.4 0.38 1.14e-12 Response to antidepressants and depression; CRC cis rs10504229 0.595 rs36081958 chr8:58117505 C/G cg04204079 chr8:58130323 NA -0.45 -5.74 -0.3 2.18e-8 Developmental language disorder (linguistic errors); CRC cis rs3768617 0.510 rs6424888 chr1:183085696 C/T ch.1.3577855R chr1:183094577 LAMC1 -0.87 -15.26 -0.64 3.81e-40 Fuchs's corneal dystrophy; CRC cis rs10256972 0.758 rs7799391 chr7:1082566 C/G cg26608667 chr7:1196370 ZFAND2A 0.35 5.67 0.3 3.16e-8 Longevity;Endometriosis; CRC cis rs796364 0.951 rs769952 chr2:200734368 C/T cg25936922 chr2:200820526 C2orf60;C2orf47 0.7 7.82 0.4 7.23e-14 Schizophrenia; CRC cis rs1707322 1.000 rs10890382 chr1:46469674 A/G cg06784218 chr1:46089804 CCDC17 0.59 10.38 0.5 5.06e-22 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs9928842 0.823 rs889514 chr16:75272512 A/G cg08657710 chr16:75258780 CTRB1 -0.52 -6.58 -0.34 1.84e-10 Alcoholic chronic pancreatitis; CRC cis rs4728302 0.869 rs2059298 chr7:133603245 C/G cg10665199 chr7:133106180 EXOC4 0.38 5.67 0.3 3.13e-8 Intelligence;Intelligence (multi-trait analysis); CRC cis rs1983170 0.736 rs11589162 chr1:91974743 C/G cg21854759 chr1:92012499 NA 0.52 6.0 0.31 5.25e-9 Eosinophil percentage of white cells; CRC cis rs17270561 0.609 rs3778272 chr6:25767661 G/A cg16482183 chr6:26056742 HIST1H1C 0.71 9.0 0.44 1.79e-17 Iron status biomarkers; CRC cis rs7917772 0.545 rs10786681 chr10:104317357 G/T cg11453585 chr10:104263688 ACTR1A;SUFU 0.82 15.47 0.65 6.25e-41 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC cis rs11758351 0.660 rs56398712 chr6:26213868 A/G cg22723502 chr6:26240528 HIST1H4F -0.36 -5.84 -0.31 1.22e-8 Gout;Renal underexcretion gout; CRC cis rs35110281 0.807 rs28840140 chr21:45039163 T/C cg04455712 chr21:45112962 RRP1B 0.39 7.58 0.39 3.64e-13 Mean corpuscular volume; CRC trans rs7618501 1.000 rs7374183 chr3:49785133 G/A cg21582582 chr3:182698605 DCUN1D1 -0.57 -8.41 -0.42 1.24e-15 Intelligence (multi-trait analysis); CRC cis rs9649213 0.593 rs7796611 chr7:97908223 A/G cg00277769 chr7:97922759 BAIAP2L1 -0.61 -10.67 -0.51 5.06e-23 Prostate cancer (SNP x SNP interaction); CRC cis rs4713118 0.615 rs57252182 chr6:27720249 C/A cg02683197 chr6:28174875 NA 0.62 8.8 0.44 7.86e-17 Parkinson's disease; CRC cis rs7647973 0.626 rs1586827 chr3:49671224 T/C cg13072238 chr3:49761600 GMPPB -0.52 -6.1 -0.32 2.98e-9 Menarche (age at onset); CRC cis rs9660992 0.573 rs12140703 chr1:205182865 G/C cg03948781 chr1:205179583 DSTYK 0.41 5.63 0.3 3.92e-8 Mean corpuscular volume;Mean platelet volume; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg06303635 chr10:45958759 MARCH8 0.34 6.57 0.34 2.01e-10 Liver disease severity in Alagille syndrome; CRC cis rs4665809 0.938 rs6742226 chr2:26342537 A/G cg22920501 chr2:26401640 FAM59B -0.52 -7.09 -0.36 8.39e-12 Gut microbiome composition (summer); CRC cis rs826838 0.585 rs4363678 chr12:38624514 G/A cg26384229 chr12:38710491 ALG10B 0.42 6.03 0.32 4.3e-9 Heart rate; CRC cis rs12142240 0.698 rs72677585 chr1:46812374 T/C cg00530320 chr1:46809349 NSUN4 0.58 7.8 0.4 8.18e-14 Menopause (age at onset); CRC cis rs2439831 0.850 rs12441861 chr15:44060883 C/T cg15269541 chr15:43626905 ADAL -0.5 -5.92 -0.31 8.17e-9 Lung cancer in ever smokers; CRC cis rs561341 1.000 rs113676348 chr17:30244327 A/G cg23018236 chr17:30244563 NA -0.64 -8.07 -0.41 1.34e-14 Hip circumference adjusted for BMI; CRC cis rs2011503 0.882 rs10401714 chr19:19363630 G/A cg11584989 chr19:19387371 SF4 0.48 5.99 0.31 5.51e-9 Bipolar disorder; CRC cis rs72945132 0.882 rs7928686 chr11:70134528 T/C cg00319359 chr11:70116639 PPFIA1 0.67 7.4 0.38 1.13e-12 Coronary artery disease; CRC cis rs13191362 1.000 rs73035012 chr6:162997279 G/A cg21926612 chr6:163149169 PACRG;PARK2 0.8 11.25 0.53 4.59e-25 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs9715521 0.835 rs9714848 chr4:59824650 C/T cg11281224 chr4:60001000 NA -0.38 -5.63 -0.3 3.86e-8 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs7618501 0.633 rs12485600 chr3:50025530 A/G cg05623727 chr3:50126028 RBM5 0.45 7.4 0.38 1.14e-12 Intelligence (multi-trait analysis); CRC cis rs1218582 0.803 rs7531728 chr1:154840516 C/A cg16680214 chr1:154839983 KCNN3 -0.52 -9.79 -0.48 4.87e-20 Prostate cancer; CRC cis rs10464366 0.746 rs17171537 chr7:39145647 C/T cg18850127 chr7:39170497 POU6F2 0.51 6.83 0.35 4.01e-11 IgG glycosylation; CRC cis rs35306767 0.951 rs12777021 chr10:967270 T/C cg20503657 chr10:835505 NA 1.04 12.55 0.57 8.83e-30 Eosinophil percentage of granulocytes; CRC cis rs3858526 1.000 rs11039787 chr11:5965611 C/T cg05234568 chr11:5960015 NA -0.6 -8.19 -0.41 5.78e-15 DNA methylation (variation); CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg15345369 chr2:10262827 RRM2 -0.39 -6.1 -0.32 2.99e-9 Myopia (pathological); CRC cis rs932541 1.000 rs6105610 chr20:16457333 A/C cg17003395 chr20:16555519 KIF16B 0.41 5.66 0.3 3.38e-8 Intelligence; CRC cis rs10540 1.000 rs12419766 chr11:503710 C/T cg03934478 chr11:495069 RNH1 0.69 7.77 0.39 9.92e-14 Body mass index; CRC cis rs477895 1.000 rs7939107 chr11:64034773 C/T cg23719950 chr11:63933701 MACROD1 -0.55 -5.89 -0.31 9.3e-9 Mean platelet volume; CRC cis rs155076 1.000 rs261427 chr13:21860998 G/A cg25811766 chr13:21894605 NA -0.59 -6.18 -0.32 1.87e-9 White matter hyperintensity burden; CRC cis rs769267 0.965 rs2916068 chr19:19516433 A/G cg01262667 chr19:19385393 TM6SF2 0.37 6.13 0.32 2.46e-9 Tonsillectomy; CRC trans rs61931739 0.500 rs7295779 chr12:34460652 T/C cg13010199 chr12:38710504 ALG10B 0.44 6.33 0.33 8.23e-10 Morning vs. evening chronotype; CRC cis rs6696846 0.936 rs6662930 chr1:205041465 T/C cg03948781 chr1:205179583 DSTYK 0.41 5.66 0.3 3.38e-8 Red blood cell count; CRC cis rs9467773 0.967 rs7753565 chr6:26560012 A/G cg09904177 chr6:26538194 HMGN4 0.85 14.85 0.63 1.61e-38 Intelligence (multi-trait analysis); CRC cis rs2645694 0.626 rs2703118 chr4:77823672 A/G cg18351406 chr4:77819688 ANKRD56 0.51 7.73 0.39 1.3e-13 Emphysema distribution in smoking; CRC cis rs9796 0.870 rs8042088 chr15:41337487 C/T cg18705301 chr15:41695430 NDUFAF1 0.36 6.02 0.32 4.54e-9 Menopause (age at onset); CRC cis rs6951245 0.938 rs78351779 chr7:1097023 G/C cg20603222 chr7:1096387 C7orf50;GPR146 -0.72 -8.67 -0.43 1.96e-16 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg16613143 chr17:2415359 METT10D 0.44 6.74 0.35 7.03e-11 Liver disease severity in Alagille syndrome; CRC cis rs79349575 0.749 rs12601672 chr17:47006493 T/C cg00947319 chr17:47005597 UBE2Z -0.35 -5.99 -0.31 5.54e-9 Type 2 diabetes; CRC cis rs34375054 0.526 rs883315 chr12:125676889 T/C cg02766259 chr12:125626809 AACS -0.45 -7.72 -0.39 1.42e-13 Post bronchodilator FEV1/FVC ratio; CRC cis rs2404602 0.716 rs117129193 chr15:76656803 A/G cg23625390 chr15:77176239 SCAPER 0.51 7.47 0.38 7.26e-13 Blood metabolite levels; CRC cis rs7539542 0.556 rs10753926 chr1:202876085 C/T cg19681188 chr1:202830198 LOC148709 0.46 6.67 0.35 1.09e-10 Mean platelet volume; CRC cis rs10197940 0.624 rs6731486 chr2:152410732 C/T cg06191203 chr2:152266755 RIF1 0.58 8.54 0.43 5.08e-16 Lung cancer; CRC cis rs7412746 0.634 rs12562939 chr1:150951452 A/C cg18016565 chr1:150552671 MCL1 0.44 6.07 0.32 3.53e-9 Melanoma; CRC cis rs35306767 0.714 rs12777800 chr10:1070361 G/A cg20503657 chr10:835505 NA 0.83 9.85 0.48 3.07e-20 Eosinophil percentage of granulocytes; CRC cis rs79387448 0.745 rs17027430 chr2:103163237 T/C cg09003973 chr2:102972529 NA 0.73 8.01 0.4 1.97e-14 Gut microbiota (bacterial taxa); CRC cis rs3796619 1.000 rs4974601 chr4:1095410 G/A cg27284194 chr4:1044797 NA 0.42 6.47 0.34 3.62e-10 Recombination rate (males); CRC cis rs2952156 0.959 rs2941504 chr17:37830900 A/G cg05616858 chr17:37843591 ERBB2;PGAP3 0.21 5.95 0.31 6.88e-9 Asthma; CRC cis rs6762 0.748 rs7936838 chr11:839093 G/C cg03116740 chr11:841335 TSPAN4;POLR2L -0.42 -7.12 -0.37 6.62e-12 Mean platelet volume; CRC cis rs853679 1.000 rs1679732 chr6:28221264 G/A cg15845792 chr6:28175446 NA -0.6 -5.98 -0.31 5.77e-9 Depression; CRC cis rs7584330 0.666 rs72620819 chr2:238354982 C/T cg16989719 chr2:238392110 NA -0.39 -6.44 -0.33 4.12e-10 Prostate cancer; CRC cis rs9814567 1.000 rs7611828 chr3:134250325 C/T cg06109529 chr3:134205091 CEP63;ANAPC13 -0.81 -12.19 -0.56 1.92e-28 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs2404602 0.692 rs2117369 chr15:76748861 A/T cg22467129 chr15:76604101 ETFA -0.45 -7.63 -0.39 2.53e-13 Blood metabolite levels; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg04267590 chr5:14581942 FAM105A 0.44 6.02 0.31 4.65e-9 Anxiety disorder; CRC cis rs2976388 0.609 rs2585149 chr8:143793320 T/C cg24046110 chr8:143859143 LYNX1 0.49 8.61 0.43 3.15e-16 Urinary tract infection frequency; CRC cis rs9911578 0.967 rs686425 chr17:56776730 A/G cg12560992 chr17:57184187 TRIM37 0.9 16.39 0.67 1.5e-44 Intelligence (multi-trait analysis); CRC cis rs1707322 1.000 rs12097761 chr1:46291162 T/C cg03146154 chr1:46216737 IPP 0.6 8.55 0.43 4.83e-16 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs13191362 1.000 rs35723993 chr6:163008197 C/T cg23758597 chr6:163146217 PARK2 -0.55 -6.12 -0.32 2.7e-9 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC trans rs116095464 0.558 rs62344300 chr5:246336 A/G cg00938859 chr5:1591904 SDHAP3 0.72 7.76 0.39 1.09e-13 Breast cancer; CRC cis rs34172651 0.917 rs200533 chr16:24754771 C/T cg06505273 chr16:24850292 NA -0.38 -5.92 -0.31 7.96e-9 Intelligence (multi-trait analysis); CRC cis rs28386778 0.897 rs2854213 chr17:61945631 T/C cg06601766 chr17:61851465 DDX42;CCDC47 0.44 5.98 0.31 5.76e-9 Prudent dietary pattern; CRC cis rs1218582 0.510 rs2878411 chr1:154823545 C/T cg16680214 chr1:154839983 KCNN3 -0.42 -7.51 -0.38 5.56e-13 Prostate cancer; CRC cis rs6724607 1.000 rs6434402 chr2:191469322 C/T cg21644426 chr2:191273491 MFSD6 -0.43 -5.84 -0.31 1.26e-8 Pulse pressure; CRC trans rs7395662 0.570 rs11039737 chr11:48450200 G/A cg15704280 chr7:45808275 SEPT13 -0.49 -7.02 -0.36 1.3e-11 HDL cholesterol; CRC cis rs2180341 0.960 rs9401952 chr6:127677027 A/C cg24812749 chr6:127587940 RNF146 0.91 13.0 0.58 1.85e-31 Breast cancer; CRC cis rs4665809 1.000 rs6750681 chr2:26329677 C/T cg26119090 chr2:26468346 HADHA;HADHB -0.62 -7.92 -0.4 3.73e-14 Gut microbiome composition (summer); CRC cis rs7219014 1 rs7219014 chr17:37624790 A/G cg20243544 chr17:37824526 PNMT 0.41 5.63 0.3 3.83e-8 Urinary metabolites; CRC cis rs9522267 0.535 rs7323631 chr13:112232269 A/G cg10483660 chr13:112241077 NA -0.47 -8.67 -0.43 1.97e-16 Hepatitis; CRC cis rs10840133 1 rs10840133 chr11:8846369 G/A cg14711859 chr11:8959438 ASCL3 -0.48 -8.17 -0.41 6.51e-15 Reticulocyte fraction of red cells; CRC cis rs6964587 0.773 rs38793 chr7:92027187 A/G cg17063962 chr7:91808500 NA -0.71 -10.64 -0.51 6.48e-23 Breast cancer; CRC cis rs2153535 0.580 rs6421948 chr6:8531020 T/C cg07606381 chr6:8435919 SLC35B3 0.66 10.8 0.51 1.82e-23 Motion sickness; CRC cis rs9479482 0.935 rs9479513 chr6:150367320 G/T cg25797454 chr6:150327115 RAET1K 0.32 5.64 0.3 3.71e-8 Alopecia areata; CRC cis rs733592 0.507 rs7299704 chr12:48444488 A/G cg21466736 chr12:48725269 NA -0.51 -8.02 -0.4 1.93e-14 Plateletcrit; CRC cis rs6502050 0.835 rs9911379 chr17:80114529 A/G cg13198984 chr17:80129470 CCDC57 0.46 8.25 0.41 3.74e-15 Life satisfaction; CRC cis rs6725517 0.737 rs7576788 chr2:25083310 A/G cg04586622 chr2:25135609 ADCY3 -0.5 -9.04 -0.45 1.41e-17 Breast cancer; CRC cis rs28386778 0.897 rs2665823 chr17:61885917 G/A cg23090583 chr17:61904693 PSMC5;FTSJ3 1.05 20.69 0.75 1.75e-61 Prudent dietary pattern; CRC cis rs727505 0.721 rs56269941 chr7:124768732 T/A cg23710748 chr7:124431027 NA -0.68 -11.61 -0.54 2.41e-26 Lewy body disease; CRC cis rs7909074 1.000 rs10751360 chr10:45396971 G/A cg05187965 chr10:45406764 TMEM72 -0.36 -8.28 -0.42 3.21e-15 Mean corpuscular volume; CRC trans rs7615952 0.546 rs2979340 chr3:125341384 C/T cg00769240 chr8:12517080 NA -0.65 -7.34 -0.38 1.67e-12 Blood pressure (smoking interaction); CRC trans rs9825823 0.617 rs2083264 chr3:61074229 A/G cg20306533 chr22:18507404 MICAL3 0.43 6.39 0.33 5.66e-10 Depressive symptom measurement or major depressive disorder; CRC cis rs7923609 0.838 rs7909960 chr10:65239177 T/A cg08743896 chr10:65200160 JMJD1C -0.43 -6.13 -0.32 2.57e-9 Educational attainment;Liver enzyme levels (alkaline phosphatase); CRC cis rs7811142 1.000 rs112317829 chr7:100043173 A/G cg00814883 chr7:100076585 TSC22D4 -0.7 -9.25 -0.45 2.94e-18 Platelet count; CRC cis rs2204008 0.715 rs11525003 chr12:38332359 G/A cg26384229 chr12:38710491 ALG10B 0.68 9.52 0.46 3.79e-19 Bladder cancer; CRC cis rs4975616 0.869 rs401681 chr5:1322087 C/T cg06550200 chr5:1325588 CLPTM1L -0.7 -11.43 -0.53 1.09e-25 Lung cancer; CRC cis rs4713118 0.513 rs156734 chr6:28007357 A/C cg10876282 chr6:28092338 ZSCAN16 0.46 6.28 0.33 1.07e-9 Parkinson's disease; CRC cis rs12681288 0.645 rs2600509 chr8:989022 C/G cg04851639 chr8:1020857 NA 0.38 7.67 0.39 1.93e-13 Schizophrenia; CRC cis rs6545883 0.929 rs10173974 chr2:61748900 C/G cg15711740 chr2:61764176 XPO1 -0.5 -6.82 -0.35 4.3e-11 Tuberculosis; CRC cis rs6951245 1.000 rs78308415 chr7:1072634 G/A cg03188948 chr7:1209495 NA 0.64 6.57 0.34 1.92e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs4713118 0.786 rs200502 chr6:27788062 C/T cg26587870 chr6:27730563 NA -0.41 -5.64 -0.3 3.61e-8 Parkinson's disease; CRC trans rs10506458 0.915 rs79133015 chr12:63396838 G/A cg22491629 chr6:157744540 C6orf35 -0.77 -9.17 -0.45 5.32e-18 Hemostatic factors and hematological phenotypes; CRC cis rs3768617 0.782 rs10911211 chr1:183022299 A/T ch.1.3577855R chr1:183094577 LAMC1 0.61 8.99 0.44 1.96e-17 Fuchs's corneal dystrophy; CRC cis rs4727027 0.933 rs34578816 chr7:148847606 G/A cg23583168 chr7:148888333 NA -0.92 -15.84 -0.66 2.09e-42 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC cis rs9584850 0.834 rs7985565 chr13:99113471 C/G cg20487152 chr13:99095054 FARP1 0.42 6.36 0.33 6.9e-10 Neuroticism; CRC cis rs4713118 0.662 rs4713120 chr6:27721835 C/A cg20933634 chr6:27740509 NA 0.39 5.74 0.3 2.1e-8 Parkinson's disease; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg17561891 chr7:86849173 C7orf23 0.34 6.07 0.32 3.62e-9 Liver disease severity in Alagille syndrome; CRC cis rs9463078 0.625 rs3799986 chr6:44900253 C/T cg25276700 chr6:44698697 NA 0.24 5.89 0.31 9.53e-9 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; CRC trans rs10411161 0.702 rs8113768 chr19:52383938 C/T cg22319618 chr22:45562946 NUP50 -0.68 -7.53 -0.38 4.85e-13 Breast cancer; CRC trans rs61931739 0.500 rs11053248 chr12:34518011 G/A cg26384229 chr12:38710491 ALG10B 0.67 8.79 0.44 8.27e-17 Morning vs. evening chronotype; CRC cis rs17023223 0.537 rs1057991 chr1:119575170 C/A cg05756136 chr1:119680316 WARS2 -0.47 -6.38 -0.33 5.84e-10 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for BMI in active individuals; CRC cis rs8072100 0.676 rs9905308 chr17:45409386 T/A cg08085267 chr17:45401833 C17orf57 -0.77 -13.88 -0.61 8.57e-35 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC trans rs2243480 0.901 rs2456483 chr7:65461575 T/C cg10756647 chr7:56101905 PSPH 0.73 7.98 0.4 2.44e-14 Diabetic kidney disease; CRC cis rs2976388 0.566 rs6998746 chr8:143802456 A/C cg05569086 chr8:143859399 LYNX1 0.42 6.92 0.36 2.35e-11 Urinary tract infection frequency; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg01685246 chr16:30538016 ZNF768 0.38 5.96 0.31 6.55e-9 Liver disease severity in Alagille syndrome; CRC cis rs3796619 0.503 rs13147452 chr4:1078124 G/A cg13468214 chr4:1046988 NA -0.33 -5.72 -0.3 2.45e-8 Recombination rate (males); CRC cis rs4594175 0.962 rs7157823 chr14:51633170 C/T cg23942311 chr14:51606299 NA 0.62 10.15 0.49 3.01e-21 Cancer; CRC cis rs916888 0.821 rs199525 chr17:44847834 T/G cg15921436 chr17:44337874 NA 0.81 8.38 0.42 1.55e-15 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs728616 0.614 rs61859198 chr10:82114628 C/A cg05935833 chr10:81318306 SFTPA2 -0.6 -7.28 -0.37 2.44e-12 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs10256972 0.524 rs6945202 chr7:1116558 T/C cg07308232 chr7:1071921 C7orf50 -0.41 -5.62 -0.3 4.03e-8 Longevity;Endometriosis; CRC cis rs1045714 0.895 rs17833498 chr7:2647007 A/G cg24848437 chr7:2645542 IQCE -0.58 -6.47 -0.34 3.45e-10 Urate levels in lean individuals; CRC cis rs514406 0.861 rs7526275 chr1:53245849 C/T cg24675658 chr1:53192096 ZYG11B 0.56 8.12 0.41 9.29e-15 Monocyte count; CRC cis rs7945705 0.967 rs10769973 chr11:8928615 C/G cg21881798 chr11:8931708 C11orf17;ST5 0.67 10.21 0.49 1.99e-21 Hemoglobin concentration; CRC cis rs7258465 1.000 rs34010330 chr19:18559657 G/C cg10790698 chr19:18539756 SSBP4 -0.44 -8.12 -0.41 9.46e-15 Breast cancer; CRC cis rs2304069 0.909 rs30831 chr5:149359053 C/T cg22760475 chr5:149380129 HMGXB3;TIGD6 -0.74 -8.3 -0.42 2.67e-15 HIV-1 control; CRC cis rs4332037 0.707 rs56070303 chr7:1891015 C/T cg23378565 chr7:2036160 MAD1L1 -0.4 -6.04 -0.32 4.11e-9 Bipolar disorder; CRC cis rs6951245 0.938 rs117729148 chr7:1108531 G/A cg20603222 chr7:1096387 C7orf50;GPR146 -0.73 -8.68 -0.43 1.92e-16 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs7224685 0.501 rs781839 chr17:3961489 C/T cg09695851 chr17:3907499 NA 0.75 14.22 0.62 4.33e-36 Type 2 diabetes; CRC cis rs4819052 0.851 rs58644915 chr21:46669912 T/C cg02159808 chr21:46707872 POFUT2;LOC642852 0.48 6.17 0.32 1.98e-9 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs10504229 0.683 rs66893068 chr8:58144238 A/G cg02725872 chr8:58115012 NA -0.63 -11.28 -0.53 3.71e-25 Developmental language disorder (linguistic errors); CRC cis rs6952808 0.717 rs12534679 chr7:1926745 G/A cg19897017 chr7:2163380 MAD1L1 0.37 5.66 0.3 3.36e-8 Bipolar disorder and schizophrenia; CRC cis rs1218582 0.600 rs72702224 chr1:154911689 G/A cg03351412 chr1:154909251 PMVK 0.51 7.22 0.37 3.73e-12 Prostate cancer; CRC cis rs3849570 1.000 rs7638516 chr3:81826249 A/C cg07356753 chr3:81810745 GBE1 -0.56 -7.87 -0.4 5.31e-14 Waist circumference;Body mass index; CRC cis rs1552244 1.000 rs17032295 chr3:10086680 C/T cg10729496 chr3:10149963 C3orf24 0.54 7.32 0.37 1.88e-12 Alzheimer's disease; CRC trans rs2727020 0.553 rs7479975 chr11:49581964 C/G cg11707556 chr5:10655725 ANKRD33B -0.41 -7.66 -0.39 2.05e-13 Coronary artery disease; CRC cis rs2354432 0.607 rs6703847 chr1:146669444 G/A cg25205988 chr1:146714368 CHD1L 1.17 9.49 0.46 4.8e-19 Mitochondrial DNA levels; CRC cis rs736408 0.609 rs2230535 chr3:52800284 T/C cg10712668 chr3:52740153 GLT8D1;SPCS1 0.38 5.6 0.3 4.47e-8 Bipolar disorder; CRC trans rs6951245 1.000 rs118059236 chr7:1073202 A/C cg13565492 chr6:43139072 SRF -0.71 -7.31 -0.37 2.04e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs2734839 0.929 rs11608185 chr11:113294976 T/C cg14159747 chr11:113255604 NA 0.46 7.95 0.4 2.95e-14 Information processing speed; CRC cis rs35000415 0.938 rs17338998 chr7:128618559 C/T cg19972273 chr7:128594194 NA 0.68 6.31 0.33 8.75e-10 Systemic lupus erythematosus; CRC cis rs861020 0.606 rs629224 chr1:210005071 C/T cg05527609 chr1:210001259 C1orf107 0.76 10.61 0.5 8.09e-23 Orofacial clefts; CRC cis rs10464366 0.544 rs4723824 chr7:39153698 T/C cg18850127 chr7:39170497 POU6F2 0.55 7.29 0.37 2.32e-12 IgG glycosylation; CRC cis rs6502050 0.835 rs4789724 chr17:80150546 G/A cg19223190 chr17:80058835 NA 0.38 6.09 0.32 3.15e-9 Life satisfaction; CRC cis rs7666738 0.791 rs13127542 chr4:98949159 C/T cg05340658 chr4:99064831 C4orf37 0.61 9.54 0.47 3.45e-19 Colonoscopy-negative controls vs population controls; CRC cis rs4304924 0.500 rs12585725 chr13:79220899 C/A cg01819759 chr13:79234251 RNF219 0.45 5.87 0.31 1.05e-8 Large artery stroke; CRC cis rs951366 0.789 rs823097 chr1:205681370 G/A cg24503407 chr1:205819492 PM20D1 0.81 12.13 0.56 3.01e-28 Menarche (age at onset); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg12763900 chr3:114866235 ZBTB20 0.44 6.31 0.33 8.76e-10 Response to antipsychotic treatment; CRC cis rs7618915 0.547 rs12496476 chr3:52708737 A/G cg18404041 chr3:52824283 ITIH1 -0.44 -9.03 -0.45 1.49e-17 Bipolar disorder; CRC cis rs7927771 0.864 rs11600581 chr11:47448497 T/C cg05585544 chr11:47624801 NA -0.52 -9.43 -0.46 7.53e-19 Subjective well-being; CRC cis rs11122272 0.668 rs2749712 chr1:231537751 T/A cg06096015 chr1:231504339 EGLN1 0.42 6.21 0.32 1.6e-9 Hemoglobin concentration; CRC cis rs10504229 0.683 rs16921937 chr8:58145010 A/G cg24829409 chr8:58192753 C8orf71 -0.56 -8.13 -0.41 9.07e-15 Developmental language disorder (linguistic errors); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg00497091 chr1:145438415 TXNIP 0.45 6.45 0.34 3.88e-10 Intelligence (multi-trait analysis); CRC cis rs9894429 1.000 rs7209180 chr17:79581519 C/A cg21984481 chr17:79567631 NPLOC4 -0.53 -9.8 -0.48 4.52e-20 Eye color traits; CRC cis rs9463078 0.739 rs6910749 chr6:44773892 A/G cg25276700 chr6:44698697 NA -0.27 -6.8 -0.35 4.92e-11 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; CRC cis rs11105298 0.891 rs10858894 chr12:89914261 T/C cg00757033 chr12:89920650 WDR51B 0.37 6.08 0.32 3.37e-9 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; CRC cis rs916888 0.773 rs199447 chr17:44812188 C/T cg15921436 chr17:44337874 NA 0.8 8.72 0.43 1.43e-16 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs10504229 0.683 rs72650847 chr8:58136825 C/T cg24829409 chr8:58192753 C8orf71 -0.67 -8.36 -0.42 1.82e-15 Developmental language disorder (linguistic errors); CRC cis rs9488822 0.676 rs13210143 chr6:116389636 G/A cg18764771 chr6:116381957 FRK 0.24 6.98 0.36 1.67e-11 Cholesterol, total;LDL cholesterol; CRC cis rs11628318 0.515 rs4906239 chr14:103078073 A/G cg12046867 chr14:103022105 NA -0.41 -5.66 -0.3 3.33e-8 Platelet count; CRC cis rs651907 0.557 rs7612283 chr3:101434919 C/T cg12386194 chr3:101231763 SENP7 0.49 7.18 0.37 4.69e-12 Colorectal cancer; CRC cis rs2204008 0.749 rs4579984 chr12:38166266 A/G cg13010199 chr12:38710504 ALG10B 0.46 6.12 0.32 2.73e-9 Bladder cancer; CRC cis rs6582630 0.539 rs12308081 chr12:38342881 C/G cg26384229 chr12:38710491 ALG10B -0.53 -7.66 -0.39 2.04e-13 Drug-induced liver injury (flucloxacillin); CRC cis rs4727027 0.933 rs1468369 chr7:148839840 G/C cg12479418 chr7:148823350 ZNF425;ZNF398 0.42 5.75 0.3 2.05e-8 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC cis rs453301 0.658 rs9329175 chr8:8866661 C/T cg06636001 chr8:8085503 FLJ10661 -0.41 -6.05 -0.32 4e-9 Joint mobility (Beighton score); CRC cis rs4561483 0.549 rs33657 chr16:11969724 G/C cg08843971 chr16:11963173 GSPT1 -0.5 -7.67 -0.39 1.99e-13 Testicular germ cell tumor; CRC cis rs734999 0.566 rs10752747 chr1:2524915 G/T cg18854424 chr1:2615690 NA 0.41 7.84 0.4 6.48e-14 Ulcerative colitis; CRC cis rs2952156 0.876 rs903501 chr17:37839493 T/C cg20243544 chr17:37824526 PNMT 0.55 8.52 0.43 5.73e-16 Asthma; CRC cis rs7259376 0.905 rs12608842 chr19:22548013 C/G cg02657401 chr19:22469223 NA 0.31 6.97 0.36 1.74e-11 Menopause (age at onset); CRC cis rs6764363 0.545 rs331858 chr3:316550 A/T cg02057681 chr3:285234 CHL1 -0.41 -6.95 -0.36 1.92e-11 Sudden cardiac arrest; CRC cis rs7666738 0.830 rs10031292 chr4:99056877 A/G cg17366294 chr4:99064904 C4orf37 0.45 7.66 0.39 2.07e-13 Colonoscopy-negative controls vs population controls; CRC trans rs7618501 1.000 rs7372730 chr3:49790682 C/G cg21659725 chr3:3221576 CRBN -0.9 -17.21 -0.69 8.44e-48 Intelligence (multi-trait analysis); CRC cis rs3760982 0.565 rs3786956 chr19:44286829 C/T cg11993925 chr19:44307056 LYPD5 0.72 12.71 0.57 2.24e-30 Breast cancer (estrogen-receptor negative);Breast cancer; CRC cis rs908922 0.676 rs908927 chr1:152513338 C/G cg23254163 chr1:152506842 NA 0.5 10.0 0.48 9.8e-21 Hair morphology; CRC cis rs9733 0.596 rs3087960 chr1:150620569 C/G cg15448220 chr1:150897856 SETDB1 0.45 6.41 0.33 4.98e-10 Tonsillectomy; CRC cis rs1862618 0.853 rs33322 chr5:56175226 A/G cg18230493 chr5:56204884 C5orf35 -0.75 -9.27 -0.45 2.61e-18 Initial pursuit acceleration; CRC cis rs6546324 0.625 rs4671813 chr2:67841835 A/T cg15745817 chr2:67799979 NA -0.56 -9.54 -0.47 3.44e-19 Endometriosis; CRC cis rs9858542 0.953 rs7622302 chr3:49547561 T/C cg03060546 chr3:49711283 APEH -0.47 -6.56 -0.34 2.08e-10 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs56283067 0.887 rs9463042 chr6:44770527 T/C cg18551225 chr6:44695536 NA -0.41 -5.67 -0.3 3.18e-8 Total body bone mineral density; CRC trans rs9393777 0.778 rs67457459 chr6:27198343 T/G cg06606381 chr12:133084897 FBRSL1 -0.9 -6.95 -0.36 1.93e-11 Intelligence (multi-trait analysis); CRC cis rs314370 0.951 rs17884589 chr7:100493711 G/A cg10426581 chr7:100472382 SRRT 0.62 7.11 0.36 7.24e-12 Resting heart rate; CRC cis rs9443645 0.505 rs11752126 chr6:79707923 C/T cg09184832 chr6:79620586 NA -0.46 -7.86 -0.4 5.67e-14 Intelligence (multi-trait analysis); CRC cis rs77956314 0.515 rs9804817 chr12:117440220 G/A cg25972092 chr12:117363249 FBXW8 -0.51 -6.08 -0.32 3.24e-9 Subcortical brain region volumes;Hippocampal volume; CRC cis rs10504229 0.906 rs7006539 chr8:58178799 A/T cg01721255 chr8:58191610 C8orf71 0.52 6.45 0.33 4.05e-10 Developmental language disorder (linguistic errors); CRC cis rs10504229 0.679 rs72649107 chr8:58030453 C/A cg22535103 chr8:58192502 C8orf71 -0.44 -6.15 -0.32 2.28e-9 Developmental language disorder (linguistic errors); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg11502736 chr1:179923845 CEP350 0.46 6.6 0.34 1.69e-10 Response to antipsychotic treatment; CRC cis rs7945705 0.967 rs10840148 chr11:8923528 C/T cg14711859 chr11:8959438 ASCL3 -0.51 -8.2 -0.41 5.62e-15 Hemoglobin concentration; CRC cis rs6502050 0.528 rs12942561 chr17:80116639 G/A cg11859384 chr17:80120422 CCDC57 -0.38 -6.0 -0.31 5.13e-9 Life satisfaction; CRC cis rs853679 0.542 rs34131763 chr6:28075000 A/C cg18032046 chr6:28092343 ZSCAN16 -0.5 -5.89 -0.31 9.34e-9 Depression; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg13257812 chr3:27525884 NA -0.38 -6.07 -0.32 3.43e-9 Myopia (pathological); CRC cis rs798554 0.836 rs798490 chr7:2801542 C/T cg19717773 chr7:2847554 GNA12 -0.46 -6.42 -0.33 4.9e-10 Height; CRC cis rs1572438 1.000 rs1572438 chr6:858970 A/G cg21062780 chr6:887772 NA 0.38 5.97 0.31 6.12e-9 Aging; CRC trans rs2014572 0.967 rs10413671 chr19:57763489 G/A cg02674126 chr19:40336878 FBL 0.42 6.74 0.35 6.98e-11 Hyperactive-impulsive symptoms; CRC cis rs11723261 0.582 rs6814287 chr4:122323 C/T cg12746427 chr4:53362 ZNF718;ZNF595 0.48 6.34 0.33 7.57e-10 Immune response to smallpox vaccine (IL-6); CRC cis rs860295 0.702 rs10752611 chr1:155509107 C/T cg02153340 chr1:155202674 NA -0.58 -6.82 -0.35 4.35e-11 Body mass index; CRC cis rs9420 0.884 rs673344 chr11:57657141 G/A cg23127183 chr11:57508653 C11orf31 0.43 5.66 0.3 3.38e-8 Schizophrenia; CRC cis rs4716602 0.596 rs10266659 chr7:156159278 A/G cg16983916 chr7:156159713 NA -0.41 -7.2 -0.37 4.05e-12 Anti-saccade response; CRC cis rs853679 0.506 rs1150693 chr6:28174590 T/C cg23161317 chr6:28129485 ZNF389 0.46 5.93 0.31 7.69e-9 Depression; CRC cis rs6582630 0.502 rs2387603 chr12:38353389 A/C cg13010199 chr12:38710504 ALG10B 0.47 6.42 0.33 4.78e-10 Drug-induced liver injury (flucloxacillin); CRC cis rs539096 0.540 rs37452 chr1:44297573 A/C cg12908607 chr1:44402522 ARTN -0.5 -9.08 -0.45 1.06e-17 Intelligence (multi-trait analysis); CRC cis rs514406 0.505 rs431459 chr1:53183230 T/G cg24675658 chr1:53192096 ZYG11B -0.67 -10.06 -0.48 6.41e-21 Monocyte count; CRC cis rs6500602 0.701 rs4785968 chr16:4535307 T/A cg13763550 chr16:4524223 NMRAL1;HMOX2 0.44 5.8 0.3 1.59e-8 Schizophrenia; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg07325233 chr21:34638662 IL10RB -0.41 -6.24 -0.33 1.37e-9 Myopia (pathological); CRC cis rs1577917 0.771 rs4383777 chr6:86435960 T/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A 0.6 8.43 0.42 1.09e-15 Response to antipsychotic treatment; CRC cis rs6815814 0.950 rs5743593 chr4:38802913 A/G cg06935464 chr4:38784597 TLR10 0.58 6.05 0.32 3.84e-9 Breast cancer; CRC trans rs877282 0.898 rs12356744 chr10:757477 G/C cg22713356 chr15:30763199 NA 1.24 14.62 0.63 1.19e-37 Uric acid levels; CRC cis rs2243480 0.803 rs160649 chr7:65543199 C/T cg18252515 chr7:66147081 NA -1.13 -13.34 -0.59 9.36e-33 Diabetic kidney disease; CRC cis rs911119 1.000 rs34897231 chr20:23620268 A/G cg16589663 chr20:23618590 CST3 0.62 8.01 0.4 2.01e-14 Chronic kidney disease; CRC cis rs67478160 0.583 rs12879612 chr14:104233618 T/A cg08213375 chr14:104286397 PPP1R13B 0.68 14.2 0.62 4.88e-36 Schizophrenia; CRC cis rs7212590 0.881 rs7216675 chr17:57882674 T/C cg10252138 chr17:58120427 NA -0.53 -5.7 -0.3 2.63e-8 Granulocyte percentage of myeloid white cells;Monocyte count;Monocyte percentage of white cells; CRC cis rs35362007 0.530 rs11621250 chr14:96011442 C/T cg13511115 chr14:96000878 GLRX5;SNHG10;SCARNA13 0.63 5.72 0.3 2.37e-8 Mean corpuscular volume;Mean corpuscular hemoglobin; CRC cis rs9894429 0.646 rs7406828 chr17:79619226 A/G cg21028142 chr17:79581711 NPLOC4 -0.34 -6.98 -0.36 1.65e-11 Eye color traits; CRC trans rs1814175 0.817 rs11040700 chr11:50023832 C/T cg11707556 chr5:10655725 ANKRD33B -0.43 -8.42 -0.42 1.17e-15 Height; CRC cis rs9302635 0.513 rs12928732 chr16:72188683 C/T cg23815491 chr16:72088622 HP 0.64 7.99 0.4 2.35e-14 Blood protein levels; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg02541231 chr11:2398776 CD81 0.46 6.41 0.33 5.13e-10 Response to antipsychotic treatment; CRC cis rs34172651 0.517 rs2303083 chr16:24835168 G/A cg02428538 chr16:24856791 SLC5A11 -0.59 -6.42 -0.33 4.78e-10 Intelligence (multi-trait analysis); CRC cis rs2204008 0.677 rs1581356 chr12:38391467 T/C cg13010199 chr12:38710504 ALG10B 0.47 6.28 0.33 1.06e-9 Bladder cancer; CRC cis rs62432291 0.681 rs425906 chr6:159657575 C/T cg14500486 chr6:159655392 FNDC1 -0.77 -10.43 -0.5 3.48e-22 Joint mobility (Beighton score); CRC cis rs6952808 0.862 rs4721135 chr7:1912222 A/G cg14004847 chr7:1930337 MAD1L1 -0.39 -5.64 -0.3 3.74e-8 Bipolar disorder and schizophrenia; CRC trans rs2243480 1.000 rs160637 chr7:65584318 C/T cg10756647 chr7:56101905 PSPH 0.73 7.68 0.39 1.79e-13 Diabetic kidney disease; CRC cis rs3820068 0.603 rs7531396 chr1:15969870 G/C cg24675056 chr1:15929824 NA 0.53 7.22 0.37 3.68e-12 Systolic blood pressure; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg05076971 chr7:117824189 NAA38 0.4 6.1 0.32 2.97e-9 Liver disease severity in Alagille syndrome; CRC cis rs4076764 0.801 rs4571944 chr1:163367975 T/C cg06092702 chr1:163392909 NA -0.52 -8.24 -0.41 4.27e-15 Motion sickness; CRC cis rs8180040 0.654 rs11714373 chr3:47214817 G/A cg27129171 chr3:47204927 SETD2 -0.73 -11.76 -0.54 6.6e-27 Colorectal cancer; CRC cis rs9462846 0.691 rs7744454 chr6:42914041 C/G cg10862848 chr6:42927986 GNMT -0.31 -6.17 -0.32 1.97e-9 Blood protein levels; CRC cis rs367615 0.552 rs10042721 chr5:108713970 C/T cg17395555 chr5:108820864 NA -0.34 -6.68 -0.35 1.04e-10 Colorectal cancer (SNP x SNP interaction); CRC cis rs6570726 0.935 rs392014 chr6:145843691 A/C cg13319975 chr6:146136371 FBXO30 -0.38 -5.77 -0.3 1.79e-8 Lobe attachment (rater-scored or self-reported); CRC cis rs3820068 0.581 rs1547031 chr1:15918960 G/A cg13390004 chr1:15929781 NA 0.5 6.9 0.36 2.6e-11 Systolic blood pressure; CRC cis rs1843834 1.000 rs4624372 chr2:225553128 A/G cg22455342 chr2:225449267 CUL3 0.48 6.38 0.33 6.04e-10 IgE levels in asthmatics (D.p. specific); CRC cis rs4713118 0.662 rs9357060 chr6:28024486 C/G cg06470822 chr6:28175283 NA 0.95 13.59 0.6 1.07e-33 Parkinson's disease; CRC cis rs11190604 1.000 rs2495737 chr10:102338344 T/C cg07080220 chr10:102295463 HIF1AN 0.49 5.92 0.31 8.05e-9 Palmitoleic acid (16:1n-7) levels; CRC cis rs1552244 0.572 rs17032440 chr3:10169819 A/C cg13047869 chr3:10149882 C3orf24 -0.55 -6.69 -0.35 9.61e-11 Alzheimer's disease; CRC cis rs10751667 0.643 rs7394436 chr11:970373 G/C cg23136738 chr11:925521 AP2A2 -0.42 -7.09 -0.36 8.19e-12 Alzheimer's disease (late onset); CRC cis rs600231 0.706 rs10896016 chr11:65335705 C/T cg17120908 chr11:65337727 SSSCA1 0.62 9.27 0.46 2.52e-18 Bone mineral density; CRC cis rs1552244 0.572 rs7645759 chr3:10157368 C/T cg16606324 chr3:10149918 C3orf24 0.67 7.74 0.39 1.2e-13 Alzheimer's disease; CRC cis rs9910055 0.530 rs11652651 chr17:42302907 A/G cg13607699 chr17:42295918 UBTF -0.8 -14.02 -0.61 2.46e-35 Total body bone mineral density; CRC cis rs4481887 1.000 rs6683717 chr1:248476792 A/G cg00666640 chr1:248458726 OR2T12 0.55 9.32 0.46 1.68e-18 Common traits (Other); CRC cis rs826838 1.000 rs7315028 chr12:38710523 G/A cg26384229 chr12:38710491 ALG10B 0.76 10.88 0.51 9.29e-24 Heart rate; CRC cis rs1958560 0.932 rs61987993 chr14:66070732 C/G cg03016385 chr14:66212404 NA -0.45 -6.19 -0.32 1.81e-9 Menarche (age at onset); CRC cis rs1552244 1.000 rs6414438 chr3:10073824 G/C cg02579736 chr3:10068473 FANCD2;CIDECP 0.96 12.87 0.58 5.44e-31 Alzheimer's disease; CRC cis rs11650494 0.710 rs76305536 chr17:47488913 G/A cg08112188 chr17:47440006 ZNF652 0.88 7.15 0.37 5.58e-12 Prostate cancer; CRC cis rs7043114 0.525 rs7023004 chr9:95098712 A/G cg13798575 chr9:95087839 CENPP;NOL8 -0.4 -5.98 -0.31 5.75e-9 Height; CRC cis rs10883723 0.810 rs3781289 chr10:104244991 G/T cg04362960 chr10:104952993 NT5C2 -0.42 -5.82 -0.31 1.39e-8 Allergic disease (asthma, hay fever or eczema); CRC cis rs9549328 0.800 rs9549616 chr13:113627762 T/G cg08614441 chr13:113633676 MCF2L -0.53 -9.31 -0.46 1.88e-18 Systolic blood pressure; CRC cis rs10504229 0.683 rs10504221 chr8:58140256 A/G cg22535103 chr8:58192502 C8orf71 -0.7 -9.34 -0.46 1.47e-18 Developmental language disorder (linguistic errors); CRC cis rs66887589 0.777 rs2017058 chr4:120257739 T/C cg09307838 chr4:120376055 NA 0.56 8.74 0.43 1.17e-16 Diastolic blood pressure; CRC cis rs62408225 0.862 rs60066732 chr6:90935383 A/G cg06866423 chr6:90926672 BACH2 0.46 7.36 0.38 1.51e-12 Eosinophil counts;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC cis rs929596 0.755 rs6742078 chr2:234672639 A/C cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 0.69 10.97 0.52 4.55e-24 Total bilirubin levels in HIV-1 infection; CRC cis rs9463078 0.764 rs1935551 chr6:44786035 T/G cg25276700 chr6:44698697 NA -0.27 -6.56 -0.34 2.14e-10 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; CRC cis rs9325144 0.647 rs3759139 chr12:39087609 G/A cg26384229 chr12:38710491 ALG10B -0.52 -7.33 -0.37 1.79e-12 Morning vs. evening chronotype; CRC cis rs230203 0.506 rs230197 chr20:55776011 T/C cg13236649 chr20:55835020 BMP7 0.42 6.27 0.33 1.14e-9 Monobrow; CRC cis rs10486722 0.565 rs11766394 chr7:41758188 T/C cg22138096 chr7:41772439 LOC285954 0.53 6.88 0.35 3e-11 Pit-and-Fissure caries; CRC cis rs6831352 0.703 rs2602862 chr4:100033221 A/G cg13256891 chr4:100009986 ADH5 0.56 7.89 0.4 4.44e-14 Alcohol dependence; CRC cis rs2072510 0.593 rs2540499 chr12:96399869 A/C cg15438951 chr12:96389694 HAL 0.49 6.2 0.32 1.66e-9 Metabolite levels (small molecules and protein measures); CRC cis rs9916302 0.706 rs801418 chr17:37457982 G/C cg00129232 chr17:37814104 STARD3 0.57 7.22 0.37 3.66e-12 Glomerular filtration rate (creatinine); CRC cis rs10833965 0.748 rs10833979 chr11:23232089 C/T cg05245346 chr11:23248277 NA 0.36 5.82 0.31 1.41e-8 Cancer; CRC cis rs747650 0.504 rs4752816 chr11:46979023 A/G cg19486271 chr11:47235900 DDB2 -0.44 -5.84 -0.31 1.24e-8 Acne (severe); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg12121587 chr11:66025327 KLC2 0.42 7.25 0.37 3.02e-12 Liver disease severity in Alagille syndrome; CRC cis rs9733 0.596 rs2175615 chr1:150624101 A/G cg15448220 chr1:150897856 SETDB1 0.45 6.43 0.33 4.42e-10 Tonsillectomy; CRC cis rs929354 0.772 rs1182432 chr7:157029176 A/G cg05182265 chr7:156933206 UBE3C -0.76 -14.56 -0.63 2.08e-37 Body mass index; CRC cis rs7917772 0.636 rs7894154 chr10:104524647 G/A cg11453585 chr10:104263688 ACTR1A;SUFU -0.69 -10.28 -0.49 1.15e-21 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC cis rs28386778 0.863 rs6504178 chr17:61812733 A/G cg11494091 chr17:61959527 GH2 -0.6 -9.98 -0.48 1.14e-20 Prudent dietary pattern; CRC cis rs523522 0.923 rs2235217 chr12:120884328 C/T cg27279351 chr12:120934652 DYNLL1 0.78 11.07 0.52 2.07e-24 High light scatter reticulocyte count; CRC trans rs61931739 0.500 rs34167298 chr12:34534338 G/A cg26384229 chr12:38710491 ALG10B 0.68 8.8 0.44 7.69e-17 Morning vs. evening chronotype; CRC cis rs60871478 0.786 rs62432898 chr7:826102 G/A cg05535760 chr7:792225 HEATR2 1.03 13.47 0.6 2.98e-33 Cerebrospinal P-tau181p levels; CRC cis rs929354 0.772 rs6957939 chr7:156978485 T/C cg16102536 chr7:156981717 UBE3C 0.4 6.77 0.35 5.77e-11 Body mass index; CRC cis rs10751667 0.643 rs7396623 chr11:934104 G/A cg06064525 chr11:970664 AP2A2 -0.31 -6.14 -0.32 2.44e-9 Alzheimer's disease (late onset); CRC cis rs6952808 0.689 rs12668156 chr7:2019875 G/A cg22963979 chr7:1858916 MAD1L1 -0.49 -6.99 -0.36 1.53e-11 Bipolar disorder and schizophrenia; CRC cis rs6952808 0.689 rs1107591 chr7:2041638 G/A cg04267008 chr7:1944627 MAD1L1 -0.77 -11.33 -0.53 2.37e-25 Bipolar disorder and schizophrenia; CRC cis rs11123610 0.520 rs66646194 chr2:3720420 G/A cg10645314 chr2:3704589 ALLC -0.55 -6.43 -0.33 4.47e-10 Response to inhaled corticosteroid treatment in asthma (change in FEV1); CRC trans rs35847492 1.000 rs17730481 chr8:9276163 A/G cg06636001 chr8:8085503 FLJ10661 -0.45 -6.51 -0.34 2.73e-10 Neuroticism; CRC cis rs9303401 0.659 rs34382037 chr17:56643550 G/T cg10487724 chr17:56770010 TEX14;RAD51C 0.79 9.64 0.47 1.58e-19 Cognitive test performance; CRC cis rs12900413 0.687 rs8034777 chr15:90313057 C/T cg24249390 chr15:90295951 MESP1 0.57 9.24 0.45 3.11e-18 Coronary artery aneurysm in Kawasaki disease; CRC cis rs924607 1.000 rs2455331 chr5:643593 T/C cg24163568 chr5:669837 TPPP 0.43 6.84 0.35 3.94e-11 Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia; CRC cis rs6545883 0.929 rs2593625 chr2:61668769 C/T cg15711740 chr2:61764176 XPO1 -0.47 -6.12 -0.32 2.64e-9 Tuberculosis; CRC cis rs514406 0.798 rs4351588 chr1:53263826 A/T cg24675658 chr1:53192096 ZYG11B 0.74 11.66 0.54 1.62e-26 Monocyte count; CRC cis rs6681460 0.932 rs492109 chr1:67187133 C/A cg02459107 chr1:67143332 SGIP1 -0.35 -6.02 -0.31 4.72e-9 Presence of antiphospholipid antibodies; CRC cis rs2760061 0.784 rs708116 chr1:228198196 C/A cg18477163 chr1:228402036 OBSCN 0.44 7.4 0.38 1.12e-12 Diastolic blood pressure; CRC cis rs60733400 0.817 rs4648657 chr1:2560735 A/G cg20673091 chr1:2541236 MMEL1 -0.39 -6.24 -0.33 1.31e-9 Multiple sclerosis; CRC cis rs7811142 1.000 rs11761784 chr7:100039970 C/T cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.62 8.34 0.42 2.09e-15 Platelet count; CRC cis rs2243480 1.000 rs160639 chr7:65579987 C/G cg25985355 chr7:65971099 NA -0.49 -5.73 -0.3 2.27e-8 Diabetic kidney disease; CRC cis rs6951245 0.872 rs75493422 chr7:1072890 C/T cg24642844 chr7:1081250 C7orf50 -0.79 -9.44 -0.46 6.9e-19 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs7727544 0.716 rs11955347 chr5:131567924 G/A cg22638593 chr5:131593259 PDLIM4 0.35 6.57 0.34 1.96e-10 Blood metabolite levels; CRC cis rs12476592 0.571 rs262510 chr2:63886712 A/C cg10828910 chr2:63850056 LOC388955 0.51 6.44 0.33 4.22e-10 Childhood ear infection; CRC cis rs7937682 0.889 rs558736 chr11:111500760 C/G cg09085632 chr11:111637200 PPP2R1B -0.99 -19.28 -0.73 5.73e-56 Primary sclerosing cholangitis; CRC cis rs1552244 0.882 rs68080705 chr3:10025743 C/T cg16606324 chr3:10149918 C3orf24 0.61 7.88 0.4 4.89e-14 Alzheimer's disease; CRC cis rs9427116 0.502 rs6699825 chr1:154582970 A/G cg24304309 chr1:154577895 ADAR 0.36 6.0 0.31 5.3e-9 Blood protein levels; CRC trans rs11581859 0.950 rs17390223 chr1:99361788 A/G cg12183875 chr3:169587454 LRRC31 -0.27 -6.1 -0.32 3.03e-9 Response to cognitive-behavioural therapy in anxiety disorder; CRC cis rs473651 0.904 rs508274 chr2:239337723 G/A cg18131467 chr2:239335373 ASB1 1.01 22.57 0.78 8.08e-69 Multiple system atrophy; CRC cis rs1018836 0.669 rs6471243 chr8:91656967 C/T cg16814680 chr8:91681699 NA 0.96 18.33 0.71 3.36e-52 Ejection fraction in Tripanosoma cruzi seropositivity; CRC cis rs13118159 0.550 rs1137789 chr4:1381798 A/G cg20887711 chr4:1340912 KIAA1530 0.68 9.65 0.47 1.42e-19 Longevity; CRC cis rs9457247 0.534 rs9366078 chr6:167399512 A/G cg23791538 chr6:167370224 RNASET2 0.49 7.89 0.4 4.5e-14 Crohn's disease; CRC cis rs57221529 0.713 rs12522724 chr5:590742 T/C cg16447950 chr5:562315 NA -0.79 -10.45 -0.5 2.87e-22 Lung disease severity in cystic fibrosis; CRC cis rs12188164 0.965 rs11744539 chr5:451425 C/T cg16322479 chr5:444228 EXOC3;C5orf55 0.51 8.4 0.42 1.38e-15 Cystic fibrosis severity; CRC cis rs67311347 0.955 rs4974068 chr3:40376929 T/C cg24209194 chr3:40518798 ZNF619 0.38 5.71 0.3 2.53e-8 Renal cell carcinoma; CRC cis rs8062405 0.792 rs12446550 chr16:28543381 G/A cg16576597 chr16:28551801 NUPR1 0.48 7.3 0.37 2.16e-12 Cognitive ability (multi-trait analysis);Cognitive ability; CRC cis rs6807915 0.504 rs167467 chr3:12281183 A/G cg04748988 chr3:12329223 PPARG 0.41 6.09 0.32 3.2e-9 Leprosy; CRC cis rs2404602 0.583 rs2139190 chr15:76555539 G/C cg26408565 chr15:76604113 ETFA -0.37 -5.91 -0.31 8.73e-9 Blood metabolite levels; CRC cis rs28386778 0.863 rs2727355 chr17:61931790 C/T cg06601766 chr17:61851465 DDX42;CCDC47 0.42 5.77 0.3 1.86e-8 Prudent dietary pattern; CRC trans rs7395662 0.864 rs7483617 chr11:48551659 A/G cg21153622 chr11:89784906 NA -0.45 -7.18 -0.37 4.68e-12 HDL cholesterol; CRC cis rs8064454 0.870 rs11263763 chr17:36103565 C/T cg04198914 chr17:36106025 HNF1B -0.3 -6.73 -0.35 7.75e-11 Prostate cancer; CRC cis rs12188164 0.515 rs11742006 chr5:408529 C/T cg00976097 chr5:421733 AHRR -0.43 -5.66 -0.3 3.32e-8 Cystic fibrosis severity; CRC cis rs138880 0.542 rs9616371 chr22:50306338 G/A cg02269571 chr22:50332266 NA -0.92 -9.51 -0.46 4.22e-19 Schizophrenia; CRC cis rs12541635 0.801 rs28709304 chr8:107106368 T/G cg10147462 chr8:107024639 NA -0.39 -6.05 -0.32 3.92e-9 Age of smoking initiation; CRC cis rs11212617 1.000 rs7946955 chr11:108284833 A/G cg01991180 chr11:108092276 ATM;NPAT 0.44 6.58 0.34 1.81e-10 Response to metformin in type 2 diabetes (glycemic); CRC cis rs4808199 0.689 rs12979148 chr19:19406869 T/C cg03709012 chr19:19516395 GATAD2A 0.93 9.49 0.46 4.98e-19 Nonalcoholic fatty liver disease; CRC cis rs12142240 0.698 rs72886907 chr1:46814265 C/T cg14993813 chr1:46806288 NSUN4 -0.5 -6.42 -0.33 4.75e-10 Menopause (age at onset); CRC cis rs7772486 0.625 rs9390355 chr6:146112942 C/T cg23711669 chr6:146136114 FBXO30 -0.69 -11.58 -0.54 3.12e-26 Lobe attachment (rater-scored or self-reported); CRC cis rs7208859 0.623 rs7208441 chr17:29143863 C/T cg01831904 chr17:28903510 LRRC37B2 -0.62 -6.41 -0.33 5.13e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs17384381 1.000 rs17384381 chr1:85897570 C/G cg16011679 chr1:85725395 C1orf52 0.58 6.25 0.33 1.24e-9 Lobe attachment (rater-scored or self-reported); CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg03118206 chr6:138482933 KIAA1244 -0.4 -5.98 -0.31 5.67e-9 Myopia (pathological); CRC cis rs13096480 0.583 rs17598137 chr3:49891362 G/T cg16322302 chr3:49157769 USP19 0.45 6.59 0.34 1.73e-10 Intelligence (multi-trait analysis); CRC cis rs644799 0.710 rs11021309 chr11:95501898 C/A cg25478527 chr11:95522999 CEP57;FAM76B 0.5 7.62 0.39 2.68e-13 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs7618915 0.571 rs11130307 chr3:52607682 G/A cg11645453 chr3:52864694 ITIH4 0.35 6.07 0.32 3.59e-9 Bipolar disorder; CRC cis rs9311474 1.000 rs9311474 chr3:52338852 T/C cg08222913 chr3:52553049 STAB1 -0.37 -7.02 -0.36 1.28e-11 Electroencephalogram traits; CRC cis rs67340775 0.541 rs200966 chr6:27862152 T/C cg02683197 chr6:28174875 NA 0.67 6.74 0.35 7.09e-11 Lung cancer in ever smokers; CRC cis rs916888 0.531 rs183211 chr17:44788310 G/A cg01570182 chr17:44337453 NA 0.77 9.62 0.47 1.8e-19 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs7274811 0.744 rs6141411 chr20:32157934 G/A cg14921437 chr20:32255988 NECAB3;C20orf134 -0.44 -6.26 -0.33 1.21e-9 Height; CRC cis rs7618915 0.547 rs4687638 chr3:52651966 A/C cg18099408 chr3:52552593 STAB1 -0.44 -7.12 -0.37 6.88e-12 Bipolar disorder; CRC cis rs6543140 0.964 rs62154972 chr2:103048738 G/A cg04239558 chr2:103089729 SLC9A4 0.37 6.37 0.33 6.43e-10 Blood protein levels; CRC cis rs17767392 0.958 rs12894478 chr14:71825113 T/C cg13720639 chr14:72061746 SIPA1L1 -0.54 -6.77 -0.35 5.81e-11 Mitral valve prolapse; CRC cis rs2011503 1.000 rs754256 chr19:19578591 A/G cg11584989 chr19:19387371 SF4 -0.59 -6.77 -0.35 5.76e-11 Bipolar disorder; CRC cis rs798554 0.642 rs2533871 chr7:2883006 C/G cg19717773 chr7:2847554 GNA12 -0.44 -6.2 -0.32 1.67e-9 Height; CRC cis rs34375054 0.660 rs12578446 chr12:125605887 A/G cg06287003 chr12:125626642 AACS -0.59 -8.16 -0.41 7.21e-15 Post bronchodilator FEV1/FVC ratio; CRC cis rs10504229 1.000 rs67388517 chr8:58176617 C/A cg02725872 chr8:58115012 NA -0.38 -6.43 -0.33 4.44e-10 Developmental language disorder (linguistic errors); CRC cis rs12476592 0.543 rs262480 chr2:63873032 A/G cg10828910 chr2:63850056 LOC388955 0.5 6.21 0.32 1.63e-9 Childhood ear infection; CRC cis rs7927592 0.913 rs10896330 chr11:68254998 A/G cg01657329 chr11:68192670 LRP5 -0.46 -6.67 -0.35 1.05e-10 Total body bone mineral density; CRC cis rs1997103 1.000 rs6977292 chr7:55396335 T/C cg17469321 chr7:55412551 NA 0.74 11.44 0.53 9.61e-26 QRS interval (sulfonylurea treatment interaction); CRC cis rs9287719 0.967 rs4284804 chr2:10722124 C/T cg00105475 chr2:10696890 NA 0.45 7.26 0.37 2.75e-12 Prostate cancer; CRC cis rs9818758 0.607 rs73084135 chr3:49272218 A/G cg01304814 chr3:48885189 PRKAR2A 0.75 5.76 0.3 1.88e-8 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg03779258 chr22:34316655 LARGE 0.38 6.25 0.33 1.27e-9 Liver disease severity in Alagille syndrome; CRC cis rs7264396 0.563 rs2425089 chr20:34304036 G/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.48 -6.67 -0.35 1.06e-10 Total cholesterol levels; CRC cis rs1816752 0.789 rs7986037 chr13:25012853 A/G cg02811702 chr13:24901961 NA 0.47 6.55 0.34 2.21e-10 Obesity-related traits; CRC cis rs6582630 0.576 rs4882258 chr12:38453686 C/T cg26384229 chr12:38710491 ALG10B -0.55 -7.95 -0.4 2.93e-14 Drug-induced liver injury (flucloxacillin); CRC cis rs12922317 0.589 rs350216 chr16:12151140 C/T cg02368508 chr16:12060182 TNFRSF17 0.41 6.11 0.32 2.8e-9 Schizophrenia; CRC cis rs10870270 0.913 rs4550 chr10:133781798 C/T cg08754478 chr10:133766260 PPP2R2D -0.66 -8.99 -0.44 2.04e-17 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; CRC cis rs7107174 1.000 rs10899465 chr11:78013588 G/A cg02023728 chr11:77925099 USP35 0.53 7.49 0.38 6.52e-13 Testicular germ cell tumor; CRC cis rs908922 0.651 rs11205035 chr1:152532832 A/G cg09873164 chr1:152488093 CRCT1 0.4 6.75 0.35 6.85e-11 Hair morphology; CRC cis rs9900062 0.546 rs2428352 chr17:62694738 C/T cg02097616 chr17:62675921 NA -0.52 -7.4 -0.38 1.14e-12 QT interval; CRC trans rs7615952 0.932 rs7629977 chr3:125649573 T/G cg00769240 chr8:12517080 NA -0.54 -6.72 -0.35 8.02e-11 Blood pressure (smoking interaction); CRC cis rs9354352 0.935 rs7766730 chr6:66697003 C/A cg07460842 chr6:66804631 NA 0.62 9.07 0.45 1.07e-17 Initial pursuit acceleration in psychotic disorders; CRC cis rs636291 0.517 rs12565133 chr1:10544988 A/C cg17425144 chr1:10567563 PEX14 -0.51 -11.71 -0.54 1.06e-26 Prostate cancer; CRC cis rs9486715 0.830 rs1475748 chr6:97034143 T/C cg06623918 chr6:96969491 KIAA0776 -1.02 -20.71 -0.75 1.42e-61 Headache; CRC cis rs7618501 0.633 rs6772095 chr3:49978069 C/T cg24110177 chr3:50126178 RBM5 -0.45 -6.71 -0.35 8.44e-11 Intelligence (multi-trait analysis); CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg00964710 chr16:14726998 BFAR 0.45 6.12 0.32 2.65e-9 Anxiety disorder; CRC cis rs7772486 0.875 rs969694 chr6:146394655 A/G cg13319975 chr6:146136371 FBXO30 -0.38 -5.8 -0.3 1.57e-8 Lobe attachment (rater-scored or self-reported); CRC cis rs79839061 0.518 rs3755960 chr4:895060 G/T cg14530993 chr4:882597 GAK 0.8 7.59 0.39 3.35e-13 Intelligence (multi-trait analysis); CRC cis rs2797160 1.000 rs1777195 chr6:126006861 A/C cg05901451 chr6:126070800 HEY2 0.41 6.26 0.33 1.17e-9 Endometrial cancer; CRC trans rs7395662 1.000 rs1809986 chr11:48987539 C/A cg21153622 chr11:89784906 NA -0.49 -7.76 -0.39 1.08e-13 HDL cholesterol; CRC cis rs13064411 0.696 rs9814395 chr3:113188885 C/T cg10517650 chr3:113235015 CCDC52 -0.37 -6.57 -0.34 1.97e-10 Response to simvastatin treatment (PCSK9 protein level change); CRC cis rs7937682 0.889 rs497111 chr11:111499512 G/A cg09085632 chr11:111637200 PPP2R1B -1.0 -19.85 -0.74 3.48e-58 Primary sclerosing cholangitis; CRC cis rs1448094 0.512 rs11117057 chr12:86248546 C/T cg02569458 chr12:86230093 RASSF9 0.43 7.41 0.38 1.06e-12 Major depressive disorder; CRC cis rs10504229 0.683 rs7459958 chr8:58111905 G/T cg04204079 chr8:58130323 NA -0.46 -5.84 -0.31 1.22e-8 Developmental language disorder (linguistic errors); CRC cis rs10788264 0.504 rs4751883 chr10:124018027 A/C cg05683857 chr10:124030795 BTBD16 0.33 6.05 0.32 3.95e-9 Total body bone mineral density; CRC cis rs6681460 1.000 rs6659968 chr1:67123459 C/T cg02459107 chr1:67143332 SGIP1 0.48 8.33 0.42 2.27e-15 Presence of antiphospholipid antibodies; CRC cis rs2228479 0.850 rs62054610 chr16:89816920 G/A cg06656553 chr16:89960601 TCF25 -0.69 -5.74 -0.3 2.15e-8 Skin colour saturation; CRC cis rs9311474 0.581 rs13621 chr3:52558133 T/C cg15147215 chr3:52552868 STAB1 -0.63 -11.26 -0.53 4.41e-25 Electroencephalogram traits; CRC cis rs10089 1.000 rs6595800 chr5:127411647 C/T cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.74 10.66 0.51 5.41e-23 Ileal carcinoids; CRC cis rs2204008 0.580 rs11520047 chr12:38051778 T/A cg13010199 chr12:38710504 ALG10B 0.44 5.64 0.3 3.74e-8 Bladder cancer; CRC trans rs11098499 0.865 rs3956464 chr4:120256764 T/C cg25214090 chr10:38739885 LOC399744 0.54 8.52 0.43 5.9e-16 Corneal astigmatism; CRC cis rs9611565 0.559 rs13056262 chr22:42081921 A/G cg06634786 chr22:41940651 POLR3H 0.61 6.86 0.35 3.38e-11 Vitiligo; CRC cis rs713587 0.563 rs7605335 chr2:25109317 G/A cg04586622 chr2:25135609 ADCY3 -0.56 -10.5 -0.5 1.91e-22 Body mass index in non-asthmatics; CRC cis rs7945705 0.712 rs61876274 chr11:9019190 A/T cg14711859 chr11:8959438 ASCL3 -0.39 -6.48 -0.34 3.36e-10 Hemoglobin concentration; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg03630683 chr3:4534997 ITPR1 0.53 7.63 0.39 2.49e-13 Response to antipsychotic treatment; CRC cis rs6088590 1.000 rs6119535 chr20:33442138 A/C cg08999081 chr20:33150536 PIGU 0.42 6.98 0.36 1.6e-11 Coronary artery disease; CRC cis rs796364 1.000 rs4410273 chr2:200818258 T/C cg12253985 chr2:200820533 C2orf60;C2orf47 0.63 6.78 0.35 5.51e-11 Schizophrenia; CRC cis rs1046896 0.731 rs8067667 chr17:80785875 A/G cg19046167 chr17:80928561 B3GNTL1 0.49 6.7 0.35 9.06e-11 Glycated hemoglobin levels; CRC cis rs7833790 0.700 rs7825180 chr8:82723991 T/A cg17211192 chr8:82754475 SNX16 -0.47 -6.68 -0.35 1.03e-10 Diastolic blood pressure; CRC cis rs2204008 0.627 rs1851117 chr12:38398987 G/T cg13010199 chr12:38710504 ALG10B 0.47 6.32 0.33 8.35e-10 Bladder cancer; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg17979952 chr6:117803953 DCBLD1 0.43 6.11 0.32 2.88e-9 Response to antipsychotic treatment; CRC cis rs7781557 0.640 rs66712128 chr7:102616987 T/C cg18108683 chr7:102477205 FBXL13 -0.49 -5.97 -0.31 6.01e-9 Colorectal adenoma (advanced); CRC cis rs2289583 0.642 rs55798479 chr15:75392210 C/T cg14664628 chr15:75095509 CSK 0.42 5.79 0.3 1.66e-8 Systemic lupus erythematosus; CRC cis rs9837602 1.000 rs1038294 chr3:99503728 A/G cg07805332 chr3:99536008 MIR548G;C3orf26 0.45 5.94 0.31 7.07e-9 Breast cancer; CRC cis rs7809950 0.798 rs2701684 chr7:107299527 C/T cg23024343 chr7:107201750 COG5 0.46 6.94 0.36 2.1e-11 Coronary artery disease; CRC cis rs17155006 0.655 rs424978 chr7:107724747 C/G cg05962710 chr7:107745446 LAMB4 -0.35 -5.85 -0.31 1.21e-8 Pneumococcal bacteremia; CRC cis rs11190604 1.000 rs11190592 chr10:102291059 T/C cg07080220 chr10:102295463 HIF1AN 0.47 5.68 0.3 3.03e-8 Palmitoleic acid (16:1n-7) levels; CRC cis rs79839061 0.610 rs62297087 chr4:913289 T/A cg07828340 chr4:882639 GAK 1.12 10.87 0.51 1.01e-23 Intelligence (multi-trait analysis); CRC cis rs1577917 0.771 rs2783171 chr6:86382765 C/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A 0.71 9.41 0.46 9.13e-19 Response to antipsychotic treatment; CRC cis rs738322 0.805 rs2016755 chr22:38539604 A/G cg17652424 chr22:38574118 PLA2G6 -0.18 -5.65 -0.3 3.49e-8 Cutaneous nevi; CRC cis rs826838 0.967 rs826870 chr12:39120250 G/A cg26384229 chr12:38710491 ALG10B -0.62 -9.5 -0.46 4.57e-19 Heart rate; CRC cis rs7512552 0.839 rs698916 chr1:150388385 A/G cg15654264 chr1:150340011 RPRD2 0.59 8.52 0.43 5.96e-16 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); CRC cis rs61160187 0.582 rs62367872 chr5:60272770 A/G cg16298547 chr5:60138761 ELOVL7 -0.27 -5.73 -0.3 2.26e-8 Educational attainment (years of education);Educational attainment (college completion); CRC cis rs4700695 0.841 rs706680 chr5:65317338 T/C cg21114390 chr5:65439923 SFRS12 0.58 7.04 0.36 1.16e-11 Facial morphology (factor 19); CRC cis rs9818758 0.607 rs73074866 chr3:49626666 C/T cg00383909 chr3:49044727 WDR6 1.38 11.76 0.54 7.04e-27 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; CRC cis rs7833986 1.000 rs7833986 chr8:57100149 C/T cg23139584 chr8:56987506 RPS20;SNORD54 0.57 7.64 0.39 2.43e-13 Height; CRC cis rs2180341 0.960 rs7751865 chr6:127683040 G/A cg24812749 chr6:127587940 RNF146 0.9 12.86 0.58 6.12e-31 Breast cancer; CRC trans rs474558 0.597 rs574293 chr10:99699426 G/A cg05303249 chr11:66036138 RAB1B -0.58 -8.6 -0.43 3.2e-16 Nonsyndromic cleft lip with cleft palate; CRC cis rs2580764 0.540 rs10174838 chr2:55241216 A/T cg09592903 chr2:55203963 RTN4 -0.72 -11.58 -0.54 3.13e-26 Mean platelet volume; CRC cis rs875971 0.505 rs6955582 chr7:65431686 A/G cg11764359 chr7:65958608 NA 0.51 7.76 0.39 1.09e-13 Aortic root size; CRC cis rs172166 0.694 rs1631552 chr6:28089699 C/A cg23161317 chr6:28129485 ZNF389 0.46 6.51 0.34 2.82e-10 Cardiac Troponin-T levels; CRC cis rs11098499 0.909 rs10014719 chr4:120320715 G/A cg09307838 chr4:120376055 NA 0.71 11.02 0.52 2.9e-24 Corneal astigmatism; CRC cis rs12477438 0.765 rs7591992 chr2:99668954 A/C cg14399236 chr2:99771627 LIPT1;TSGA10 -0.6 -8.19 -0.41 6.03e-15 Chronic sinus infection; CRC cis rs8014204 0.935 rs3742786 chr14:75373011 A/G cg03030879 chr14:75389066 RPS6KL1 0.55 8.98 0.44 2.1e-17 Caffeine consumption; CRC cis rs870825 0.616 rs4623061 chr4:185643161 A/C cg04058563 chr4:185651563 MLF1IP 0.72 9.42 0.46 8.15e-19 Blood protein levels; CRC cis rs6582630 0.615 rs3914894 chr12:38480280 C/T cg26384229 chr12:38710491 ALG10B -0.52 -7.62 -0.39 2.79e-13 Drug-induced liver injury (flucloxacillin); CRC cis rs12188164 0.762 rs11745923 chr5:475408 T/G cg21972741 chr5:435613 AHRR 0.55 7.45 0.38 8.34e-13 Cystic fibrosis severity; CRC cis rs2836974 0.666 rs4818015 chr21:40675493 A/C cg17971929 chr21:40555470 PSMG1 0.69 10.54 0.5 1.47e-22 Cognitive function; CRC cis rs1005277 0.522 rs289647 chr10:37968278 A/G cg25427524 chr10:38739819 LOC399744 -0.71 -11.81 -0.55 4.63e-27 Extrinsic epigenetic age acceleration; CRC cis rs1008375 0.966 rs3775923 chr4:17585625 T/C cg16339924 chr4:17578868 LAP3 0.66 8.52 0.42 6e-16 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs7615952 0.641 rs61048217 chr3:125807905 G/T cg06494592 chr3:125709126 NA -0.58 -6.85 -0.35 3.57e-11 Blood pressure (smoking interaction); CRC cis rs2066819 1.000 rs41392645 chr12:56696742 A/G cg26714650 chr12:56694279 CS -1.38 -11.56 -0.54 3.59e-26 Psoriasis vulgaris; CRC cis rs3789045 0.520 rs2010432 chr1:204462619 G/T cg17419461 chr1:204415978 PIK3C2B -0.57 -7.86 -0.4 5.39e-14 Educational attainment (college completion); CRC cis rs7618915 0.501 rs1866268 chr3:52719398 C/A cg11645453 chr3:52864694 ITIH4 0.36 6.5 0.34 2.9e-10 Bipolar disorder; CRC cis rs6502050 0.799 rs4789673 chr17:80123218 T/C cg09264619 chr17:80180166 NA -0.35 -5.93 -0.31 7.47e-9 Life satisfaction; CRC cis rs4819052 0.851 rs2838856 chr21:46680766 T/G cg11663144 chr21:46675770 NA -0.7 -11.59 -0.54 2.78e-26 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs1572438 0.811 rs9379179 chr6:879853 A/C cg13447295 chr6:887704 NA 0.59 8.84 0.44 5.86e-17 Aging; CRC cis rs6502050 0.769 rs9904237 chr17:80119664 G/A cg09264619 chr17:80180166 NA -0.35 -5.93 -0.31 7.47e-9 Life satisfaction; CRC cis rs7517126 1.000 rs7519501 chr1:196840173 T/C cg13682187 chr1:196946512 CFHR5 -0.37 -6.02 -0.32 4.6e-9 Blood protein levels; CRC cis rs1580019 0.563 rs10486509 chr7:32585443 C/G cg06627557 chr7:32535165 LSM5;AVL9 -0.97 -18.18 -0.71 1.32e-51 Cognitive ability; CRC trans rs7615952 0.576 rs6804482 chr3:125815762 C/T cg07211511 chr3:129823064 LOC729375 -0.7 -9.29 -0.46 2.22e-18 Blood pressure (smoking interaction); CRC cis rs7615952 0.641 rs66520539 chr3:125780374 G/A cg05084668 chr3:125655381 ALG1L -0.45 -6.47 -0.34 3.59e-10 Blood pressure (smoking interaction); CRC cis rs9733 0.596 rs72702557 chr1:150680130 A/G cg18016565 chr1:150552671 MCL1 0.45 6.52 0.34 2.57e-10 Tonsillectomy; CRC trans rs7726839 0.555 rs4541696 chr5:581053 A/G cg25482853 chr8:67687455 SGK3 0.45 6.04 0.32 4.27e-9 Obesity-related traits; CRC cis rs7149337 0.805 rs3007164 chr14:51646935 A/G cg18683604 chr14:51561293 TRIM9 0.29 5.66 0.3 3.25e-8 Cancer; CRC cis rs909002 0.962 rs7537646 chr1:32135495 G/A cg13919466 chr1:32135498 COL16A1 -0.41 -7.97 -0.4 2.58e-14 Intelligence (multi-trait analysis); CRC cis rs7493 1.000 rs7786401 chr7:95034001 G/T cg07404485 chr7:94953653 PON1 -0.47 -6.25 -0.33 1.27e-9 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs1552244 0.554 rs2272118 chr3:10049287 T/C cg00166722 chr3:10149974 C3orf24 0.43 6.37 0.33 6.36e-10 Alzheimer's disease; CRC cis rs12477438 0.765 rs7340412 chr2:99661148 G/A cg14399236 chr2:99771627 LIPT1;TSGA10 -0.6 -8.19 -0.41 6.03e-15 Chronic sinus infection; CRC cis rs951366 0.764 rs823141 chr1:205741426 T/C cg14893161 chr1:205819251 PM20D1 0.83 13.48 0.6 2.7e-33 Menarche (age at onset); CRC cis rs10979 1.000 rs7774497 chr6:143889033 T/C cg25407410 chr6:143891975 LOC285740 -0.82 -13.4 -0.59 5.5e-33 Hypospadias; CRC cis rs9372498 0.536 rs25422 chr6:118807847 A/G cg07617317 chr6:118971624 C6orf204 -0.51 -6.03 -0.32 4.34e-9 Diastolic blood pressure; CRC cis rs425277 0.538 rs169037 chr1:2095582 G/T cg24578937 chr1:2090814 PRKCZ 0.39 7.12 0.37 6.97e-12 Height; CRC cis rs2522056 1.000 rs1003533 chr5:131755651 C/T cg24060327 chr5:131705240 SLC22A5 0.47 6.38 0.33 5.86e-10 Lymphocyte counts;Fibrinogen; CRC cis rs9911578 0.835 rs723991 chr17:56482039 G/A cg12560992 chr17:57184187 TRIM37 -0.83 -14.33 -0.62 1.65e-36 Intelligence (multi-trait analysis); CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg06363041 chr3:131100598 NUDT16 0.47 6.4 0.33 5.48e-10 Anxiety disorder; CRC cis rs79387448 0.638 rs116055209 chr2:103032189 C/T cg09003973 chr2:102972529 NA 0.87 9.46 0.46 6.05e-19 Gut microbiota (bacterial taxa); CRC cis rs6546550 0.901 rs12613947 chr2:70161342 A/G cg02498382 chr2:70120550 SNRNP27 -0.56 -9.54 -0.47 3.39e-19 Prevalent atrial fibrillation; CRC cis rs2153535 0.580 rs969421 chr6:8451949 A/C cg21535247 chr6:8435926 SLC35B3 0.5 7.45 0.38 8.15e-13 Motion sickness; CRC cis rs3768617 0.510 rs20563 chr1:183085755 C/T ch.1.3577855R chr1:183094577 LAMC1 -0.84 -14.77 -0.63 3.04e-38 Fuchs's corneal dystrophy; CRC cis rs7618501 0.933 rs1128535 chr3:49866392 C/T cg24308560 chr3:49941425 MST1R -0.45 -7.12 -0.37 6.61e-12 Intelligence (multi-trait analysis); CRC cis rs11677416 1.000 rs6542094 chr2:113528625 A/G cg06156847 chr2:113672199 IL1F7 -0.39 -5.96 -0.31 6.34e-9 Response to antipsychotic treatment in schizophrenia (working memory); CRC cis rs28386778 0.897 rs1062791 chr17:61896487 C/T cg25654072 chr17:61904446 PSMC5;FTSJ3 0.72 11.27 0.53 3.95e-25 Prudent dietary pattern; CRC cis rs10865541 1.000 rs10165099 chr2:3402591 T/C cg22182287 chr2:3452347 TTC15 0.38 5.92 0.31 7.98e-9 Obesity-related traits; CRC cis rs9487051 0.872 rs9487032 chr6:109605323 G/T cg12927641 chr6:109611667 NA -0.38 -6.77 -0.35 6.05e-11 Reticulocyte fraction of red cells; CRC cis rs9467773 1.000 rs6924838 chr6:26571756 C/T cg09904177 chr6:26538194 HMGN4 0.86 14.82 0.63 2.06e-38 Intelligence (multi-trait analysis); CRC cis rs35306767 0.714 rs67696450 chr10:1090684 C/T cg20503657 chr10:835505 NA 0.83 9.88 0.48 2.57e-20 Eosinophil percentage of granulocytes; CRC cis rs801193 1.000 rs6958520 chr7:66151453 T/C cg05627663 chr7:65219948 SNORA22;CCT6P1 0.44 6.43 0.33 4.52e-10 Aortic root size; CRC cis rs875971 0.502 rs2465121 chr7:65621004 A/G cg02869306 chr7:64672164 INTS4L1 0.44 6.18 0.32 1.9e-9 Aortic root size; CRC cis rs490234 0.702 rs13287071 chr9:128268224 T/C cg14078157 chr9:128172775 NA -0.41 -6.66 -0.34 1.17e-10 Mean arterial pressure; CRC cis rs989128 0.642 rs8077316 chr17:48626389 C/T cg16068336 chr17:48637367 CACNA1G -0.54 -7.73 -0.39 1.3e-13 Type 2 diabetes; CRC cis rs12368653 0.666 rs701007 chr12:58113416 C/A cg00677455 chr12:58241039 CTDSP2 -0.48 -6.98 -0.36 1.63e-11 Multiple sclerosis; CRC trans rs12599106 0.624 rs2173885 chr16:34992749 G/A cg15383120 chr6:291909 DUSP22 -0.59 -8.25 -0.41 3.86e-15 Menopause (age at onset); CRC cis rs12048904 0.505 rs10493936 chr1:101213335 A/T cg16556008 chr1:101360663 SLC30A7;EXTL2 -0.81 -12.52 -0.57 1.09e-29 Multiple sclerosis; CRC cis rs7589728 1.000 rs75181745 chr2:88520408 C/T cg24977027 chr2:88469347 THNSL2 0.55 6.52 0.34 2.67e-10 Plasma clusterin levels; CRC trans rs264943 0.714 rs264938 chr2:104296743 C/T cg14722509 chr5:170815938 NPM1 -0.42 -5.96 -0.31 6.48e-9 HIV-1 viral setpoint; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg04665351 chr12:3000000 TULP3 0.36 6.67 0.35 1.11e-10 Liver disease severity in Alagille syndrome; CRC cis rs981844 0.740 rs12644642 chr4:154686550 G/C cg10279832 chr4:154682576 RNF175 0.39 5.91 0.31 8.67e-9 Response to statins (LDL cholesterol change); CRC cis rs7927771 0.929 rs66749409 chr11:47568074 C/T cg18512352 chr11:47633146 NA -0.48 -9.61 -0.47 1.97e-19 Subjective well-being; CRC cis rs597539 0.652 rs514296 chr11:68654182 G/T cg06112835 chr11:68658793 MRPL21 0.48 7.88 0.4 4.7e-14 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs6582630 0.502 rs11181230 chr12:38300085 A/G cg13010199 chr12:38710504 ALG10B 0.46 6.25 0.33 1.3e-9 Drug-induced liver injury (flucloxacillin); CRC trans rs1005277 0.579 rs2474594 chr10:38426661 G/C cg23533926 chr12:111358616 MYL2 -0.53 -7.97 -0.4 2.55e-14 Extrinsic epigenetic age acceleration; CRC cis rs7259376 0.902 rs12978477 chr19:22577709 C/G cg02657401 chr19:22469223 NA 0.3 6.63 0.34 1.37e-10 Menopause (age at onset); CRC cis rs9399135 0.967 rs2183709 chr6:135377091 C/T cg22676075 chr6:135203613 NA 0.4 6.13 0.32 2.52e-9 Red blood cell count; CRC cis rs4969178 0.965 rs938350 chr17:76399552 C/T cg05887092 chr17:76393375 PGS1 0.54 9.57 0.47 2.67e-19 HDL cholesterol levels; CRC cis rs3741151 0.686 rs11822984 chr11:73261467 A/C cg17517138 chr11:73019481 ARHGEF17 0.83 7.15 0.37 5.59e-12 GIP levels in response to oral glucose tolerance test (120 minutes); CRC cis rs4713118 0.513 rs149975 chr6:27986340 G/A cg10876282 chr6:28092338 ZSCAN16 0.47 6.36 0.33 6.71e-10 Parkinson's disease; CRC cis rs3796352 0.881 rs11710394 chr3:53015839 A/G cg07884673 chr3:53033167 SFMBT1 0.67 5.89 0.31 9.73e-9 Immune reponse to smallpox (secreted IL-2); CRC cis rs6912958 0.559 rs499373 chr6:88042062 A/T cg12350822 chr6:88032061 C6orf162;GJB7 0.5 10.24 0.49 1.54e-21 Monocyte percentage of white cells; CRC cis rs4588572 0.570 rs2362832 chr5:77795843 A/G cg11547950 chr5:77652471 NA -0.55 -7.63 -0.39 2.51e-13 Triglycerides; CRC cis rs7666738 0.830 rs2903150 chr4:99027184 T/C cg05340658 chr4:99064831 C4orf37 0.61 9.42 0.46 8.23e-19 Colonoscopy-negative controls vs population controls; CRC cis rs28386778 0.863 rs3760256 chr17:61821161 A/G cg06601766 chr17:61851465 DDX42;CCDC47 0.44 5.98 0.31 5.83e-9 Prudent dietary pattern; CRC cis rs8180040 0.764 rs6794193 chr3:47114904 T/C cg10298567 chr3:47292165 KIF9 -0.37 -6.0 -0.31 5.28e-9 Colorectal cancer; CRC cis rs751728 1.000 rs9394166 chr6:33751122 G/C cg25922239 chr6:33757077 LEMD2 0.62 9.75 0.47 6.91e-20 Crohn's disease; CRC cis rs769267 0.965 rs12977937 chr19:19429975 C/G cg17414380 chr19:19431394 KIAA0892;SF4 0.41 5.62 0.3 4.08e-8 Tonsillectomy; CRC cis rs6860806 0.507 rs273912 chr5:131661349 A/C cg18758796 chr5:131593413 PDLIM4 -0.39 -6.34 -0.33 7.79e-10 Breast cancer; CRC cis rs72627123 0.867 rs57482759 chr14:74485523 G/A cg12022184 chr14:74485813 ENTPD5;C14orf45 0.72 6.19 0.32 1.8e-9 Morning vs. evening chronotype; CRC cis rs6717918 0.887 rs13020779 chr2:233149600 A/G ch.2.233013039R chr2:233304795 NA 0.47 6.57 0.34 2e-10 Height; CRC cis rs4481887 0.927 rs7521689 chr1:248435831 G/T cg13385794 chr1:248469461 NA 0.4 7.0 0.36 1.47e-11 Common traits (Other); CRC cis rs7772486 0.625 rs2050027 chr6:146116113 C/G cg23711669 chr6:146136114 FBXO30 -0.69 -11.73 -0.54 8.89e-27 Lobe attachment (rater-scored or self-reported); CRC cis rs908922 0.676 rs1538082 chr1:152517304 A/G cg09873164 chr1:152488093 CRCT1 0.37 6.18 0.32 1.88e-9 Hair morphology; CRC cis rs7086803 1.000 rs11196087 chr10:114506406 C/T cg03281572 chr10:114502318 VTI1A -0.73 -6.13 -0.32 2.53e-9 Lung cancer; CRC cis rs8062405 0.895 rs56186137 chr16:28825953 A/G cg08761264 chr16:28874980 SH2B1 -0.42 -5.62 -0.3 4.08e-8 Cognitive ability (multi-trait analysis);Cognitive ability; CRC cis rs11792861 0.781 rs28361106 chr9:111762385 T/C cg05043794 chr9:111880884 C9orf5 -0.32 -5.65 -0.3 3.41e-8 Menarche (age at onset); CRC cis rs13108904 0.875 rs73069950 chr4:1276045 C/A cg16405210 chr4:1374714 KIAA1530 0.41 5.83 0.31 1.36e-8 Obesity-related traits; CRC cis rs6952808 1.000 rs4719319 chr7:1888094 G/A cg02951883 chr7:2050386 MAD1L1 -0.73 -11.61 -0.54 2.39e-26 Bipolar disorder and schizophrenia; CRC cis rs6586163 1.000 rs7072828 chr10:90754953 T/G cg03111039 chr10:90751583 FAS;ACTA2 -0.5 -7.31 -0.37 2.03e-12 Chronic lymphocytic leukemia; CRC cis rs2067615 0.579 rs10746066 chr12:107129108 G/A cg13491945 chr12:107078410 RFX4 0.35 5.96 0.31 6.44e-9 Heart rate; CRC trans rs7615952 0.515 rs4441610 chr3:125681307 C/G cg07211511 chr3:129823064 LOC729375 -0.72 -9.79 -0.47 5e-20 Blood pressure (smoking interaction); CRC cis rs4561483 0.743 rs28653099 chr16:12009150 C/A cg08843971 chr16:11963173 GSPT1 0.5 7.41 0.38 1.05e-12 Testicular germ cell tumor; CRC cis rs34526934 0.608 rs7591820 chr2:177028144 G/T cg10305451 chr2:177043427 NA -0.53 -6.85 -0.35 3.71e-11 Obstructive sleep apnea trait (apnea hypopnea index); CRC cis rs651907 0.514 rs10936744 chr3:101433440 C/T cg12386194 chr3:101231763 SENP7 0.49 7.12 0.37 6.68e-12 Colorectal cancer; CRC cis rs7937682 0.793 rs7130440 chr11:111417779 A/G cg09085632 chr11:111637200 PPP2R1B 0.64 9.03 0.45 1.46e-17 Primary sclerosing cholangitis; CRC cis rs6952808 0.929 rs12667688 chr7:1931030 C/T cg04267008 chr7:1944627 MAD1L1 -0.83 -12.34 -0.56 5.29e-29 Bipolar disorder and schizophrenia; CRC cis rs9487051 0.676 rs9400268 chr6:109600550 C/T cg12927641 chr6:109611667 NA -0.35 -6.23 -0.32 1.44e-9 Reticulocyte fraction of red cells; CRC cis rs73206853 0.764 rs7312939 chr12:110564108 G/A cg12870014 chr12:110450643 ANKRD13A 0.76 8.87 0.44 4.59e-17 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC trans rs75804782 0.641 rs72985397 chr2:239341354 A/G cg01134436 chr17:81009848 B3GNTL1 0.73 6.93 0.36 2.21e-11 Morning vs. evening chronotype;Chronotype; CRC cis rs5769765 0.720 rs138820 chr22:50164078 A/G cg02269571 chr22:50332266 NA -0.5 -6.92 -0.36 2.36e-11 Schizophrenia; CRC cis rs2933343 0.553 rs35979399 chr3:128697313 G/A cg11901034 chr3:128598214 ACAD9 -0.6 -8.01 -0.4 2.04e-14 IgG glycosylation; CRC cis rs4588572 0.643 rs6453396 chr5:77785387 T/C cg11547950 chr5:77652471 NA -0.54 -7.24 -0.37 3.14e-12 Triglycerides; CRC cis rs4253772 0.550 rs12165597 chr22:46705584 A/G cg24881330 chr22:46731750 TRMU 0.59 6.36 0.33 6.75e-10 LDL cholesterol;Cholesterol, total; CRC cis rs17767392 0.958 rs56407721 chr14:71963503 T/C cg13720639 chr14:72061746 SIPA1L1 -0.57 -7.25 -0.37 2.94e-12 Mitral valve prolapse; CRC cis rs801193 0.935 rs3800820 chr7:66147178 C/T cg25985355 chr7:65971099 NA 0.32 5.6 0.3 4.48e-8 Aortic root size; CRC cis rs2077654 0.556 rs11024284 chr11:17444590 C/T cg25308976 chr11:17434268 ABCC8 0.61 6.95 0.36 1.95e-11 Gout; CRC cis rs853679 0.517 rs1340004 chr6:28103691 C/T cg15786705 chr6:28176104 NA 0.79 10.06 0.48 6.42e-21 Depression; CRC cis rs2115630 0.691 rs8040066 chr15:85176465 G/C cg11189052 chr15:85197271 WDR73 -0.69 -11.93 -0.55 1.61e-27 P wave terminal force; CRC cis rs6690583 1.000 rs10443172 chr1:85485768 T/C cg11262906 chr1:85462892 MCOLN2 -0.51 -6.96 -0.36 1.87e-11 Serum sulfate level; CRC trans rs10242455 0.702 rs10251282 chr7:98990236 T/C cg09045935 chr12:6379348 NA 0.99 7.45 0.38 8.27e-13 Blood metabolite levels; CRC cis rs2073300 0.609 rs6137931 chr20:23376875 G/C cg12062639 chr20:23401060 NAPB 0.74 6.78 0.35 5.43e-11 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs6540559 1.000 rs2235372 chr1:209960436 A/G cg25204440 chr1:209979598 IRF6 -0.48 -6.32 -0.33 8.36e-10 Cleft lip with or without cleft palate; CRC cis rs11690935 0.959 rs75922913 chr2:172620152 T/C cg13550731 chr2:172543902 DYNC1I2 -1.07 -17.28 -0.69 4.62e-48 Schizophrenia; CRC cis rs1800795 0.652 rs7802307 chr7:22766433 T/A cg05472934 chr7:22766657 IL6 0.79 13.49 0.6 2.56e-33 Cerebrospinal fluid clusterin levels in APOEe4- carriers; CRC cis rs736408 0.812 rs1075653 chr3:52825528 T/C cg18099408 chr3:52552593 STAB1 -0.36 -5.62 -0.3 4.08e-8 Bipolar disorder; CRC trans rs1814175 0.669 rs17472879 chr11:49499520 G/T cg21153622 chr11:89784906 NA -0.43 -7.01 -0.36 1.32e-11 Height; CRC cis rs1124376 1.000 rs9819739 chr3:20140760 G/A cg05072819 chr3:20081367 KAT2B 0.51 6.24 0.33 1.33e-9 Bipolar disorder and schizophrenia; CRC cis rs12188164 0.543 rs2672722 chr5:453567 G/A cg21625146 chr5:486483 SLC9A3 0.37 5.83 0.31 1.34e-8 Cystic fibrosis severity; CRC cis rs6879260 1.000 rs729568 chr5:179732350 C/T cg02891314 chr5:179741120 GFPT2 0.67 10.33 0.49 7.48e-22 Height; CRC cis rs2160860 0.729 rs56838465 chr8:39801480 G/T cg11363097 chr8:39792086 IDO2 -0.45 -7.58 -0.39 3.66e-13 Blood metabolite levels; CRC cis rs9902453 0.740 rs2244247 chr17:28110174 G/A cg26525008 chr17:28256777 EFCAB5;SSH2 -0.72 -12.11 -0.56 3.76e-28 Coffee consumption (cups per day); CRC cis rs7246657 0.943 rs7253091 chr19:37967214 C/T cg23950597 chr19:37808831 NA -0.47 -5.88 -0.31 9.92e-9 Coronary artery calcification; CRC cis rs2839186 0.934 rs2839197 chr21:47708133 A/G cg02776659 chr21:47717406 C21orf57 -0.34 -5.62 -0.3 4.13e-8 Testicular germ cell tumor; CRC cis rs782590 0.967 rs1975484 chr2:55803167 T/A cg18811423 chr2:55921094 PNPT1 0.79 14.73 0.63 4.46e-38 Metabolic syndrome; CRC cis rs9381040 0.674 rs3747742 chr6:41162518 C/T cg03644281 chr6:41068752 NFYA;LOC221442 0.5 7.17 0.37 5.1e-12 Alzheimer's disease (late onset); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg22853526 chr1:113216965 MOV10 0.42 6.22 0.32 1.55e-9 Response to antipsychotic treatment; CRC cis rs1008375 1.000 rs10805358 chr4:17652450 A/C cg16339924 chr4:17578868 LAP3 0.57 7.69 0.39 1.78e-13 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs9818758 0.607 rs113186424 chr3:49272726 T/C cg00383909 chr3:49044727 WDR6 1.16 11.72 0.54 9.45e-27 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; CRC trans rs6500957 0.920 rs17648524 chr16:7459683 C/G cg22359107 chr11:18655812 SPTY2D1 0.41 5.98 0.31 5.7e-9 Spherical equivalent (joint analysis main effects and education interaction); CRC trans rs2303319 0.504 rs1006428 chr2:162592559 A/C cg03774468 chr3:140950104 ACPL2 -0.65 -6.07 -0.32 3.61e-9 Cognitive function; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg20894110 chr13:23949701 SACS 0.36 6.1 0.32 2.97e-9 Liver disease severity in Alagille syndrome; CRC trans rs9354352 0.791 rs4710306 chr6:66700271 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.56 -8.3 -0.42 2.68e-15 Initial pursuit acceleration in psychotic disorders; CRC cis rs9902453 0.704 rs2617874 chr17:28085172 C/G cg26525008 chr17:28256777 EFCAB5;SSH2 0.61 9.17 0.45 5.23e-18 Coffee consumption (cups per day); CRC cis rs875971 1.000 rs7789768 chr7:65938980 A/C cg12463550 chr7:65579703 CRCP 0.48 6.78 0.35 5.54e-11 Aortic root size; CRC cis rs4713118 0.629 rs149899 chr6:28019979 C/T cg06470822 chr6:28175283 NA 0.91 13.28 0.59 1.54e-32 Parkinson's disease; CRC cis rs10979 1.000 rs12738 chr6:143890049 A/G cg25407410 chr6:143891975 LOC285740 -0.82 -13.4 -0.59 5.5e-33 Hypospadias; CRC cis rs1218582 0.711 rs4845677 chr1:154838050 C/T cg09359103 chr1:154839909 KCNN3 -0.69 -12.24 -0.56 1.26e-28 Prostate cancer; CRC cis rs1023500 0.505 rs134899 chr22:42683030 T/G cg15557168 chr22:42548783 NA -0.39 -6.73 -0.35 7.77e-11 Schizophrenia; CRC cis rs514406 0.861 rs1571979 chr1:53237526 G/A cg08859206 chr1:53392774 SCP2 0.44 6.74 0.35 6.94e-11 Monocyte count; CRC cis rs4563143 0.514 rs73029081 chr19:29295583 C/G cg12667521 chr19:29218732 NA 0.53 7.31 0.37 2.11e-12 Methadone dose in opioid dependence; CRC cis rs9399137 0.507 rs11759077 chr6:135381351 A/G cg24558204 chr6:135376177 HBS1L 0.6 8.93 0.44 3.13e-17 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; CRC cis rs6502050 0.764 rs35416122 chr17:80119006 A/G cg13198984 chr17:80129470 CCDC57 0.47 8.35 0.42 1.88e-15 Life satisfaction; CRC cis rs1670533 1.000 rs641987 chr4:1077542 C/T cg27284194 chr4:1044797 NA 0.49 6.24 0.33 1.37e-9 Recombination rate (females); CRC cis rs801193 0.548 rs2659891 chr7:66201114 A/G cg18876405 chr7:65276391 NA 0.51 8.3 0.42 2.8e-15 Aortic root size; CRC cis rs1129187 0.755 rs28868299 chr6:42921221 T/G cg27588902 chr6:42928151 GNMT -0.41 -7.41 -0.38 1.06e-12 Alzheimer's disease in APOE e4+ carriers; CRC cis rs10504229 0.683 rs6999984 chr8:58115079 G/A cg02725872 chr8:58115012 NA -0.65 -11.61 -0.54 2.36e-26 Developmental language disorder (linguistic errors); CRC cis rs76533333 0.646 rs71446911 chr13:113377528 G/T cg04656015 chr13:113407548 ATP11A 0.78 5.85 0.31 1.19e-8 Red cell distribution width; CRC cis rs782590 1.000 rs782594 chr2:55844445 T/C cg18811423 chr2:55921094 PNPT1 0.81 14.79 0.63 2.59e-38 Metabolic syndrome; CRC cis rs1707322 0.717 rs1547925 chr1:46085356 C/T cg06784218 chr1:46089804 CCDC17 -0.65 -11.88 -0.55 2.53e-27 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs2730245 0.505 rs1188956 chr7:158690576 G/A cg24397884 chr7:158709396 WDR60 0.84 13.13 0.59 6.07e-32 Height; CRC cis rs736408 0.812 rs6778329 chr3:52824610 G/A cg08222913 chr3:52553049 STAB1 -0.33 -5.7 -0.3 2.66e-8 Bipolar disorder; CRC cis rs41271473 0.706 rs72763990 chr1:228719071 A/T cg16512390 chr1:228756714 NA 0.68 6.36 0.33 6.65e-10 Chronic lymphocytic leukemia; CRC cis rs6502050 0.835 rs8081949 chr17:80117490 G/A cg11859384 chr17:80120422 CCDC57 -0.37 -5.98 -0.31 5.86e-9 Life satisfaction; CRC cis rs4713118 0.586 rs6905516 chr6:28086478 A/G cg21251018 chr6:28226885 NKAPL 0.48 6.19 0.32 1.84e-9 Parkinson's disease; CRC trans rs11098499 0.863 rs6858777 chr4:120475966 A/G cg25214090 chr10:38739885 LOC399744 0.66 10.41 0.5 4.04e-22 Corneal astigmatism; CRC cis rs62064224 0.902 rs17732573 chr17:30627664 C/T cg18200150 chr17:30822561 MYO1D -0.6 -12.26 -0.56 1.06e-28 Schizophrenia; CRC cis rs12586317 0.576 rs10146445 chr14:35631553 C/T cg07166546 chr14:35805898 NA -0.31 -6.02 -0.31 4.66e-9 Psoriasis; CRC cis rs853679 0.517 rs9348797 chr6:28137533 G/C cg03623178 chr6:28175578 NA 0.98 12.66 0.57 3.31e-30 Depression; CRC cis rs6502050 0.731 rs9891378 chr17:80116035 T/C cg09264619 chr17:80180166 NA -0.35 -5.97 -0.31 5.98e-9 Life satisfaction; CRC cis rs391936 0.568 rs2931137 chr2:8466655 A/T cg12167548 chr2:8464763 NA 0.34 6.41 0.33 5.13e-10 Selective IgA deficiency; CRC cis rs9868809 0.542 rs9873726 chr3:48712367 C/T cg00383909 chr3:49044727 WDR6 0.6 6.3 0.33 9.36e-10 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; CRC cis rs12142240 0.698 rs41294458 chr1:46810304 T/C cg00530320 chr1:46809349 NSUN4 0.58 7.98 0.4 2.46e-14 Menopause (age at onset); CRC cis rs9911578 0.740 rs368243 chr17:56708979 T/C cg12560992 chr17:57184187 TRIM37 0.75 12.07 0.55 5.24e-28 Intelligence (multi-trait analysis); CRC cis rs62244186 0.748 rs13319803 chr3:44635461 G/A cg11003573 chr3:44754125 ZNF502 -0.34 -5.9 -0.31 8.88e-9 Depressive symptoms; CRC cis rs9322193 0.923 rs9372044 chr6:150102003 G/A cg05861140 chr6:150128134 PCMT1 -0.43 -7.05 -0.36 1.03e-11 Lung cancer; CRC cis rs9943753 0.508 rs11066422 chr12:109807153 A/G cg19025524 chr12:109796872 NA -0.53 -7.96 -0.4 2.77e-14 HDL cholesterol; CRC cis rs7174755 0.743 rs4777035 chr15:68605169 C/T cg22576950 chr15:68522787 CLN6 -0.33 -5.6 -0.3 4.48e-8 Major depressive disorder; CRC cis rs6460942 1.000 rs6944134 chr7:12418036 T/C cg06484146 chr7:12443880 VWDE -0.74 -8.41 -0.42 1.3e-15 Coronary artery disease; CRC cis rs58688157 0.705 rs11539530 chr11:609353 G/A cg03909863 chr11:638404 DRD4 -0.52 -7.01 -0.36 1.36e-11 Systemic lupus erythematosus; CRC cis rs9894429 0.646 rs12948797 chr17:79617384 G/A cg21028142 chr17:79581711 NPLOC4 0.35 7.0 0.36 1.48e-11 Eye color traits; CRC cis rs3540 0.618 rs11609 chr15:91043765 C/G cg22089800 chr15:90895588 ZNF774 -0.57 -9.47 -0.46 5.63e-19 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; CRC cis rs9322193 0.923 rs9767309 chr6:150037943 A/G cg13206674 chr6:150067644 NUP43 0.65 9.75 0.47 6.68e-20 Lung cancer; CRC cis rs17152411 1.000 rs12569940 chr10:126592684 T/C cg07906193 chr10:126599966 NA 0.61 6.82 0.35 4.36e-11 Height; CRC trans rs10911184 0.818 rs4652755 chr1:182953945 A/G cg14803869 chr12:131237682 NA 0.53 6.21 0.32 1.56e-9 Diabetic kidney disease; CRC cis rs9341808 0.718 rs9359408 chr6:80820132 T/G cg08355045 chr6:80787529 NA 0.43 6.88 0.35 2.95e-11 Sitting height ratio; CRC cis rs3617 0.625 rs2535633 chr3:52859630 C/G cg07507251 chr3:52567010 NT5DC2 -0.4 -6.22 -0.32 1.52e-9 Red blood cell count;Autism spectrum disorder or schizophrenia; CRC cis rs4774899 0.500 rs2170463 chr15:56931766 A/G cg08128148 chr15:57256372 TCF12 -0.39 -5.63 -0.3 3.96e-8 Urinary tract infection frequency; CRC cis rs9814567 1.000 rs12490835 chr3:134223730 T/C cg06541857 chr3:134203789 ANAPC13;CEP63 -0.4 -6.01 -0.31 4.88e-9 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC trans rs1814175 0.817 rs10839397 chr11:49857074 C/T cg03929089 chr4:120376271 NA -0.92 -17.29 -0.69 4.09e-48 Height; CRC cis rs9311474 0.581 rs4687626 chr3:52569098 G/A cg15147215 chr3:52552868 STAB1 -0.68 -12.04 -0.55 6.74e-28 Electroencephalogram traits; CRC cis rs10504229 0.728 rs72650855 chr8:58152570 A/G cg02290350 chr8:58132656 NA -0.51 -6.57 -0.34 1.98e-10 Developmental language disorder (linguistic errors); CRC cis rs9916302 0.706 rs11657153 chr17:37699729 A/G cg07936489 chr17:37558343 FBXL20 -0.92 -11.89 -0.55 2.39e-27 Glomerular filtration rate (creatinine); CRC cis rs2072499 0.966 rs2842882 chr1:156165342 T/G cg06970220 chr1:156163860 SLC25A44 0.49 6.92 0.36 2.31e-11 Testicular germ cell tumor; CRC cis rs1552244 0.554 rs3732963 chr3:10048885 G/T cg02579736 chr3:10068473 FANCD2;CIDECP 0.68 9.51 0.46 4.18e-19 Alzheimer's disease; CRC cis rs10208940 0.777 rs6726966 chr2:68855856 A/G cg12452813 chr2:68675892 NA 0.46 5.76 0.3 1.96e-8 Urate levels in lean individuals; CRC cis rs9992667 0.911 rs28656945 chr4:38666746 G/A cg19726192 chr4:38663646 FLJ13197 -0.72 -8.86 -0.44 5.09e-17 Eosinophil percentage of granulocytes; CRC cis rs910316 0.663 rs175034 chr14:75463687 T/G cg08847533 chr14:75593920 NEK9 -0.85 -14.35 -0.62 1.33e-36 Height; CRC cis rs7811142 0.775 rs6946768 chr7:99954393 G/A cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.09 14.63 0.63 1.06e-37 Platelet count; CRC cis rs8180040 0.966 rs12486969 chr3:47429003 G/C cg02527881 chr3:46936655 PTH1R 0.37 6.74 0.35 6.98e-11 Colorectal cancer; CRC cis rs9916302 0.904 rs8081338 chr17:37406139 C/T cg03013999 chr17:37608204 MED1 0.49 7.44 0.38 8.92e-13 Glomerular filtration rate (creatinine); CRC cis rs883565 0.792 rs784492 chr3:39175576 A/C cg01426195 chr3:39028469 NA -0.37 -5.65 -0.3 3.48e-8 Handedness; CRC cis rs10992471 0.603 rs7864575 chr9:95304647 G/A cg14631576 chr9:95140430 CENPP -0.38 -6.59 -0.34 1.75e-10 Visceral adipose tissue/subcutaneous adipose tissue ratio; CRC cis rs9549328 0.800 rs1317507 chr13:113631780 G/T cg25790453 chr13:113633590 MCF2L -0.55 -9.64 -0.47 1.55e-19 Systolic blood pressure; CRC cis rs12048904 0.533 rs1590580 chr1:101292668 A/G cg16556008 chr1:101360663 SLC30A7;EXTL2 0.86 12.91 0.58 4.08e-31 Multiple sclerosis; CRC cis rs2153535 0.580 rs9406143 chr6:8444583 C/T cg21535247 chr6:8435926 SLC35B3 0.48 7.24 0.37 3.19e-12 Motion sickness; CRC cis rs6500602 0.893 rs6500596 chr16:4470027 G/T cg14951292 chr16:4525986 HMOX2;NMRAL1 0.66 8.57 0.43 4.23e-16 Schizophrenia; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg26011156 chr1:156183096 PMF1 0.44 6.37 0.33 6.46e-10 Intelligence (multi-trait analysis); CRC cis rs7666738 0.830 rs6532724 chr4:99060993 C/T cg17366294 chr4:99064904 C4orf37 0.44 7.49 0.38 6.54e-13 Colonoscopy-negative controls vs population controls; CRC cis rs904251 0.523 rs914348 chr6:37484729 G/A cg01843034 chr6:37503916 NA -0.43 -8.15 -0.41 7.61e-15 Cognitive performance; CRC trans rs2228479 0.702 rs62053702 chr16:89860688 G/T cg24644049 chr4:85504048 CDS1 0.83 6.97 0.36 1.69e-11 Skin colour saturation; CRC cis rs875971 0.505 rs1167386 chr7:65513096 G/A cg00343986 chr7:65444356 GUSB -0.56 -8.44 -0.42 1.05e-15 Aortic root size; CRC cis rs9549367 0.713 rs3024776 chr13:113827075 A/G cg18105134 chr13:113819100 PROZ 0.86 12.87 0.58 5.43e-31 Platelet distribution width; CRC cis rs3751196 1.000 rs2289258 chr12:104173880 G/A cg02344784 chr12:104178138 NT5DC3 0.71 7.47 0.38 7.22e-13 Sense of smell; CRC cis rs780096 0.526 rs7594812 chr2:27611469 A/G cg21248554 chr2:27665150 KRTCAP3 -0.31 -7.14 -0.37 5.9e-12 Total body bone mineral density; CRC cis rs6502050 0.605 rs35158616 chr17:80094480 A/G cg11859384 chr17:80120422 CCDC57 -0.39 -6.08 -0.32 3.27e-9 Life satisfaction; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg08494812 chr2:9983427 TAF1B 0.44 6.23 0.32 1.45e-9 Intelligence (multi-trait analysis); CRC cis rs55665837 0.961 rs12795972 chr11:14443775 C/T cg19336497 chr11:14380999 RRAS2 -0.39 -6.61 -0.34 1.58e-10 Vitamin D levels; CRC cis rs172166 0.694 rs203893 chr6:28062066 C/A cg06470822 chr6:28175283 NA 0.82 12.23 0.56 1.37e-28 Cardiac Troponin-T levels; CRC cis rs9467711 0.591 rs13208859 chr6:25894609 G/A cg08501292 chr6:25962987 TRIM38 1.15 10.02 0.48 8.32e-21 Autism spectrum disorder or schizophrenia; CRC cis rs17376456 0.877 rs12716460 chr5:93416733 A/G cg09848695 chr5:92956644 FAM172A;MIR2277 0.63 5.83 0.31 1.29e-8 Diabetic retinopathy; CRC cis rs9467711 0.606 rs2076030 chr6:26426856 G/A cg14345882 chr6:26364793 BTN3A2 0.7 5.75 0.3 2.03e-8 Autism spectrum disorder or schizophrenia; CRC trans rs1997103 0.954 rs1917769 chr7:55392325 T/A cg20935933 chr6:143382018 AIG1 0.5 6.47 0.34 3.65e-10 QRS interval (sulfonylurea treatment interaction); CRC cis rs2204008 0.837 rs12146734 chr12:38237079 A/G cg13010199 chr12:38710504 ALG10B 0.45 5.82 0.31 1.39e-8 Bladder cancer; CRC cis rs12753569 0.748 rs6668566 chr1:76507675 C/G cg00791851 chr1:76518896 NA 0.37 6.42 0.33 4.67e-10 Personality dimensions; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg08235057 chr22:21057110 TMEM191A 0.43 6.36 0.33 6.71e-10 Intelligence (multi-trait analysis); CRC trans rs10842750 1.000 rs10842750 chr12:26690565 G/T cg03877919 chr17:3572250 TMEM93;TAX1BP3 0.51 6.35 0.33 7.3e-10 Kashin-Beck disease; CRC cis rs7412746 0.611 rs2864873 chr1:150814174 A/G cg17724175 chr1:150552817 MCL1 0.48 7.1 0.36 7.85e-12 Melanoma; CRC trans rs1814175 0.645 rs28441045 chr11:50048971 C/T cg03929089 chr4:120376271 NA -0.89 -16.04 -0.66 3.41e-43 Height; CRC cis rs7659604 0.539 rs11731917 chr4:122783233 G/A cg20573242 chr4:122745356 CCNA2 0.56 8.36 0.42 1.76e-15 Type 2 diabetes; CRC cis rs9942416 0.601 rs114547168 chr5:74991903 A/G cg19683494 chr5:74908142 NA 0.42 5.6 0.3 4.42e-8 Age-related disease endophenotypes; CRC cis rs7632954 0.935 rs2014865 chr3:8522890 G/C cg03495237 chr3:8533978 NA 0.36 6.28 0.33 1.04e-9 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg10533536 chr8:145597427 ADCK5 0.44 6.39 0.33 5.75e-10 Intelligence (multi-trait analysis); CRC cis rs8062405 1.000 rs7198606 chr16:28875122 T/G cg16576597 chr16:28551801 NUPR1 0.48 6.82 0.35 4.39e-11 Cognitive ability (multi-trait analysis);Cognitive ability; CRC cis rs28386778 0.863 rs4968661 chr17:61796306 A/G cg23090583 chr17:61904693 PSMC5;FTSJ3 1.01 18.57 0.72 3.78e-53 Prudent dietary pattern; CRC cis rs7208859 0.524 rs11653605 chr17:29088385 T/G cg01831904 chr17:28903510 LRRC37B2 -0.63 -6.53 -0.34 2.51e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs3096299 0.632 rs8051537 chr16:89544384 T/A cg00750074 chr16:89608354 SPG7 -0.46 -7.04 -0.36 1.1e-11 Multiple myeloma (IgH translocation); CRC trans rs7937682 0.889 rs521155 chr11:111492563 G/A cg18187862 chr3:45730750 SACM1L 0.45 6.55 0.34 2.23e-10 Primary sclerosing cholangitis; CRC cis rs9814567 1.000 rs4974484 chr3:134219019 C/T cg06541857 chr3:134203789 ANAPC13;CEP63 -0.39 -5.86 -0.31 1.15e-8 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg02284587 chr1:64971218 CACHD1 -0.43 -6.44 -0.33 4.28e-10 Liver disease severity in Alagille syndrome; CRC cis rs3791556 0.501 rs3791536 chr2:240101713 G/A cg03281426 chr2:240109471 HDAC4 0.6 7.36 0.38 1.48e-12 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC trans rs61931739 0.736 rs7314457 chr12:34454301 G/A cg26384229 chr12:38710491 ALG10B 0.53 7.24 0.37 3.12e-12 Morning vs. evening chronotype; CRC cis rs523522 0.962 rs4767904 chr12:120930798 T/G cg12219531 chr12:120966889 COQ5 0.62 8.42 0.42 1.16e-15 High light scatter reticulocyte count; CRC cis rs9733 0.596 rs72700897 chr1:150626038 C/G cg18016565 chr1:150552671 MCL1 0.46 6.74 0.35 6.91e-11 Tonsillectomy; CRC cis rs60871478 0.947 rs62432862 chr7:807719 G/C cg05535760 chr7:792225 HEATR2 0.84 11.07 0.52 1.95e-24 Cerebrospinal P-tau181p levels; CRC cis rs11577318 0.796 rs4625269 chr1:26626967 C/A cg00852783 chr1:26633632 UBXN11 0.47 6.79 0.35 5.23e-11 Granulocyte percentage of myeloid white cells; CRC cis rs7715806 0.500 rs17563995 chr5:75007556 A/G cg19683494 chr5:74908142 NA 0.51 5.76 0.3 1.89e-8 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs4713118 0.662 rs149961 chr6:28015569 A/C cg12172441 chr6:28176163 NA 0.54 6.96 0.36 1.8e-11 Parkinson's disease; CRC cis rs2836974 0.829 rs34227163 chr21:40551943 A/G cg11890956 chr21:40555474 PSMG1 1.08 18.28 0.71 5.13e-52 Cognitive function; CRC cis rs10512697 1.000 rs11741276 chr5:3577135 C/G cg19473799 chr5:3511975 NA -0.73 -5.8 -0.3 1.53e-8 Immune response to smallpox vaccine (IL-6); CRC cis rs35110281 0.501 rs162381 chr21:44920915 A/G cg04455712 chr21:45112962 RRP1B -0.34 -5.87 -0.31 1.07e-8 Mean corpuscular volume; CRC cis rs4237845 0.837 rs7963992 chr12:58295949 G/C cg02175503 chr12:58329896 NA 0.57 8.25 0.41 3.84e-15 Intelligence (multi-trait analysis); CRC cis rs877282 0.898 rs11253350 chr10:765968 G/A cg06581033 chr10:766294 NA -0.53 -5.79 -0.3 1.61e-8 Uric acid levels; CRC cis rs2361718 0.933 rs8077849 chr17:78104137 C/T cg24585782 chr17:78113791 EIF4A3 -0.37 -5.79 -0.3 1.68e-8 Yeast infection; CRC cis rs597539 0.652 rs546382 chr11:68704264 C/T cg06112835 chr11:68658793 MRPL21 0.43 6.82 0.35 4.38e-11 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs798766 1.000 rs1665364 chr4:1727206 A/G cg05874882 chr4:1763078 NA 0.38 7.41 0.38 1.06e-12 Bladder cancer;Urinary bladder cancer; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg25136310 chr19:5690528 RPL36 0.4 6.12 0.32 2.66e-9 Liver disease severity in Alagille syndrome; CRC cis rs780096 0.565 rs813592 chr2:27721971 T/C cg27432699 chr2:27873401 GPN1 -0.52 -8.1 -0.41 1.06e-14 Total body bone mineral density; CRC cis rs4713118 0.662 rs9380045 chr6:28025279 A/G cg03623178 chr6:28175578 NA 0.92 13.02 0.58 1.52e-31 Parkinson's disease; CRC cis rs6681460 0.932 rs618093 chr1:67178428 T/G cg02459107 chr1:67143332 SGIP1 0.35 5.95 0.31 6.78e-9 Presence of antiphospholipid antibodies; CRC cis rs7312933 1.000 rs10880230 chr12:42450253 G/A cg11827402 chr12:42719852 PPHLN1;ZCRB1 0.6 7.65 0.39 2.27e-13 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CRC cis rs8060686 0.641 rs12446007 chr16:68189054 C/T cg08314208 chr16:67682810 RLTPR -0.58 -6.19 -0.32 1.76e-9 HDL cholesterol;Metabolic syndrome; CRC trans rs2303319 0.504 rs62189043 chr2:162608466 A/T cg10272801 chr16:14013773 ERCC4 -0.68 -6.07 -0.32 3.49e-9 Cognitive function; CRC cis rs12325245 0.536 rs12931124 chr16:58620063 G/A cg19824325 chr16:58548873 SETD6 1.0 6.85 0.35 3.68e-11 Schizophrenia; CRC cis rs7927771 0.864 rs2293580 chr11:47440283 T/A cg18512352 chr11:47633146 NA 0.36 7.12 0.37 6.78e-12 Subjective well-being; CRC cis rs7223966 0.921 rs67018565 chr17:61928055 C/A cg23090583 chr17:61904693 PSMC5;FTSJ3 0.57 7.12 0.37 6.77e-12 Hip circumference adjusted for BMI;Body mass index; CRC cis rs11148252 0.683 rs9536006 chr13:52887707 T/G cg12458913 chr13:53173898 NA 0.56 8.69 0.43 1.78e-16 Lewy body disease; CRC cis rs10504229 0.683 rs2318147 chr8:58114931 C/T cg05313129 chr8:58192883 C8orf71 -0.49 -5.92 -0.31 8.25e-9 Developmental language disorder (linguistic errors); CRC cis rs10849893 0.557 rs61955091 chr12:121833975 A/G cg01154721 chr12:121881891 KDM2B -0.42 -6.29 -0.33 9.94e-10 Fasting blood glucose;Fasting blood glucose (BMI interaction); CRC cis rs7615952 0.641 rs12488180 chr3:125782236 C/T cg15145296 chr3:125709740 NA -0.57 -6.75 -0.35 6.77e-11 Blood pressure (smoking interaction); CRC cis rs3096299 0.719 rs12934708 chr16:89523790 C/T cg00750074 chr16:89608354 SPG7 -0.51 -7.85 -0.4 5.82e-14 Multiple myeloma (IgH translocation); CRC cis rs425277 0.585 rs3107157 chr1:2061969 A/G cg21194808 chr1:2205498 SKI -0.38 -5.75 -0.3 2.09e-8 Height; CRC cis rs798554 0.610 rs2251491 chr7:2852835 T/C cg04166393 chr7:2884313 GNA12 0.39 5.98 0.31 5.72e-9 Height; CRC cis rs9560113 0.959 rs4771756 chr13:112176083 T/G cg10483660 chr13:112241077 NA 0.36 5.75 0.3 2e-8 Menarche (age at onset); CRC cis rs4555082 0.830 rs2735812 chr14:105727575 A/G cg10792982 chr14:105748885 BRF1 0.37 6.1 0.32 2.94e-9 Mean platelet volume;Platelet distribution width; CRC cis rs11190604 1.000 rs3763695 chr10:102269206 A/G cg16342193 chr10:102329863 NA -0.36 -6.01 -0.31 4.92e-9 Palmitoleic acid (16:1n-7) levels; CRC cis rs10256972 0.577 rs4999286 chr7:1199506 C/G cg03923535 chr7:1197113 ZFAND2A 0.72 10.76 0.51 2.5e-23 Longevity;Endometriosis; CRC cis rs12692738 0.526 rs355855 chr2:165628875 C/A cg03182029 chr2:165697222 COBLL1 0.5 5.86 0.31 1.11e-8 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);Waist-to-hip ratio adjusted for BMI in non-smokers;Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction);Waist-to-hip ratio adjusted for body mass index; CRC cis rs4731207 0.698 rs11980925 chr7:124483707 T/A cg23710748 chr7:124431027 NA 0.38 6.08 0.32 3.42e-9 Cutaneous malignant melanoma; CRC cis rs2398893 0.883 rs11999153 chr9:96835847 G/A cg14459158 chr9:96720562 NA 0.43 7.11 0.36 7.48e-12 Waist-hip ratio;Waist-to-hip ratio adjusted for body mass index; CRC cis rs9467711 0.591 rs16891315 chr6:26111756 T/C cg19084075 chr6:26124329 HIST1H2AC;HIST1H2BC 0.61 5.81 0.31 1.48e-8 Autism spectrum disorder or schizophrenia; CRC cis rs9469890 0.604 rs11758420 chr6:34503279 A/C cg17674042 chr6:34482479 PACSIN1 -0.63 -7.45 -0.38 8.35e-13 Pubertal anthropometrics;Coronary artery disease; CRC cis rs4474465 0.736 rs11237541 chr11:78261703 T/C cg02023728 chr11:77925099 USP35 -0.36 -6.15 -0.32 2.29e-9 Alzheimer's disease (survival time); CRC cis rs1008375 1.000 rs10805359 chr4:17684886 A/G cg16339924 chr4:17578868 LAP3 0.53 7.05 0.36 1.03e-11 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs7945718 0.934 rs3993110 chr11:12794530 A/C cg25843174 chr11:12811716 TEAD1 0.47 8.61 0.43 3.09e-16 Educational attainment (years of education); CRC cis rs61008539 0.815 rs6960062 chr7:884665 A/G cg15782153 chr7:917662 C7orf20 0.51 8.34 0.42 2.01e-15 Perceived unattractiveness to mosquitoes; CRC cis rs9311474 0.629 rs4282054 chr3:52566065 T/C cg18099408 chr3:52552593 STAB1 -0.64 -12.71 -0.57 2.21e-30 Electroencephalogram traits; CRC cis rs10504229 1.000 rs17805326 chr8:58169533 A/C cg01721255 chr8:58191610 C8orf71 0.47 5.77 0.3 1.87e-8 Developmental language disorder (linguistic errors); CRC cis rs3820068 0.705 rs57238793 chr1:15890029 A/G cg27534772 chr1:16042836 PLEKHM2 0.44 6.86 0.35 3.46e-11 Systolic blood pressure; CRC cis rs7635838 0.684 rs2606750 chr3:11372151 T/C cg00170343 chr3:11313890 ATG7 0.48 7.26 0.37 2.74e-12 HDL cholesterol; CRC cis rs4481887 0.830 rs9662041 chr1:248484701 A/T cg13385794 chr1:248469461 NA 0.38 6.68 0.35 1.01e-10 Common traits (Other); CRC cis rs28386778 0.897 rs9913323 chr17:61851485 C/A cg22520471 chr17:61851767 DDX42;CCDC47 0.74 11.55 0.54 3.91e-26 Prudent dietary pattern; CRC cis rs3741404 0.584 rs645461 chr11:63893694 C/T cg06243084 chr11:63990629 FERMT3 0.41 6.34 0.33 7.48e-10 Platelet count; CRC cis rs2075371 0.611 rs35428392 chr7:134019645 G/A cg02659138 chr7:134003124 SLC35B4 0.36 5.61 0.3 4.19e-8 Mean platelet volume; CRC cis rs801193 0.569 rs4717315 chr7:66178325 C/T cg18876405 chr7:65276391 NA 0.51 8.25 0.41 3.9e-15 Aortic root size; CRC cis rs7208859 0.673 rs11649765 chr17:29233888 T/A cg14008862 chr17:28927542 LRRC37B2 0.55 5.75 0.3 2.04e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs561341 1.000 rs521919 chr17:30298039 G/T cg00745463 chr17:30367425 LRRC37B -0.7 -8.48 -0.42 7.49e-16 Hip circumference adjusted for BMI; CRC trans rs2243480 1.000 rs34702770 chr7:65344823 T/C cg10756647 chr7:56101905 PSPH 0.73 7.72 0.39 1.46e-13 Diabetic kidney disease; CRC cis rs12477438 0.520 rs11123761 chr2:99705903 A/G cg26064155 chr2:99771622 LIPT1;TSGA10 0.84 14.88 0.63 1.19e-38 Chronic sinus infection; CRC cis rs13191362 1.000 rs34052221 chr6:163160803 G/A cg14584255 chr6:163149320 PACRG;PARK2 0.4 5.68 0.3 2.95e-8 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs1451375 0.959 rs6962356 chr7:50621941 T/C cg18232548 chr7:50535776 DDC 0.44 6.53 0.34 2.43e-10 Malaria; CRC cis rs2204008 0.713 rs12366709 chr12:38210179 G/A cg13010199 chr12:38710504 ALG10B 0.45 5.74 0.3 2.1e-8 Bladder cancer; CRC cis rs2408955 0.522 rs10875721 chr12:48413593 A/G cg15465823 chr12:48382534 COL2A1 -0.35 -5.73 -0.3 2.24e-8 Glycated hemoglobin levels; CRC cis rs908922 0.636 rs474086 chr1:152513431 C/T cg09873164 chr1:152488093 CRCT1 0.38 6.42 0.33 4.82e-10 Hair morphology; CRC trans rs2228479 0.702 rs17233176 chr16:89832751 G/C cg24644049 chr4:85504048 CDS1 0.87 7.11 0.36 7.24e-12 Skin colour saturation; CRC cis rs853679 0.517 rs4713141 chr6:28101678 G/C cg18032046 chr6:28092343 ZSCAN16 -0.52 -6.08 -0.32 3.3e-9 Depression; CRC cis rs7827545 1.000 rs1372662 chr8:135567046 C/G cg13086574 chr8:135490821 ZFAT -0.35 -6.2 -0.32 1.71e-9 Hypertension (SNP x SNP interaction); CRC cis rs889398 0.741 rs6499268 chr16:69906529 G/A cg00738113 chr16:70207722 CLEC18C -0.37 -6.31 -0.33 8.85e-10 Body mass index; CRC trans rs2303319 0.504 rs12470830 chr2:162429996 C/T cg09481857 chr22:21368659 P2RX6;MGC16703 -0.66 -6.16 -0.32 2.08e-9 Cognitive function; CRC trans rs11343 0.675 rs7359333 chr16:19262344 A/T cg02560615 chr16:2274210 E4F1 -0.51 -6.53 -0.34 2.47e-10 Parkinson's disease; CRC cis rs13191362 1.000 rs66789102 chr6:163104432 T/C cg23758597 chr6:163146217 PARK2 -0.67 -6.71 -0.35 8.72e-11 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs736408 0.609 rs2230535 chr3:52800284 T/C cg08222913 chr3:52553049 STAB1 -0.35 -6.27 -0.33 1.12e-9 Bipolar disorder; CRC cis rs7589728 1.000 rs6720809 chr2:88528943 T/C cg04511125 chr2:88470314 THNSL2 0.7 7.01 0.36 1.35e-11 Plasma clusterin levels; CRC cis rs13191362 1.000 rs13190742 chr6:163008758 G/A cg06582575 chr6:163149167 PACRG;PARK2 0.75 10.24 0.49 1.58e-21 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs765787 0.530 rs28815867 chr15:45526805 G/C cg24006582 chr15:45444508 DUOX1 -0.57 -8.61 -0.43 3.11e-16 Uric acid levels; CRC cis rs8072100 0.713 rs3871595 chr17:45511388 C/T cg25173405 chr17:45401733 C17orf57 -0.43 -6.44 -0.33 4.36e-10 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs1003719 0.715 rs2835644 chr21:38545610 G/T cg10648535 chr21:38446584 PIGP;TTC3 -0.48 -6.67 -0.35 1.08e-10 Eye color traits; CRC cis rs10875746 0.859 rs12305647 chr12:48582961 T/C cg26205652 chr12:48591994 NA 0.46 5.63 0.3 3.79e-8 Longevity (90 years and older); CRC cis rs7412746 0.658 rs897815 chr1:150879101 C/T cg10589385 chr1:150898437 SETDB1 -0.33 -7.02 -0.36 1.27e-11 Melanoma; CRC cis rs7937682 0.889 rs1789355 chr11:111499718 T/C cg09085632 chr11:111637200 PPP2R1B -1.0 -19.85 -0.74 3.48e-58 Primary sclerosing cholangitis; CRC cis rs7727544 0.669 rs113823725 chr5:131563501 C/G cg11843238 chr5:131593191 PDLIM4 0.35 6.49 0.34 3.23e-10 Blood metabolite levels; CRC cis rs12824058 0.831 rs12322456 chr12:130813594 A/G cg24838063 chr12:130822603 PIWIL1 0.58 9.66 0.47 1.35e-19 Menopause (age at onset); CRC trans rs7726839 0.526 rs11960159 chr5:568685 C/T cg25482853 chr8:67687455 SGK3 0.97 12.04 0.55 6.61e-28 Obesity-related traits; CRC cis rs13108904 0.901 rs6851528 chr4:1296009 G/A cg20092199 chr4:1342459 KIAA1530 0.37 6.66 0.34 1.16e-10 Obesity-related traits; CRC cis rs2303759 0.626 rs12982246 chr19:49801169 A/G cg22307029 chr19:49891270 CCDC155 0.65 8.62 0.43 2.88e-16 Multiple sclerosis; CRC cis rs6665290 0.904 rs1343744 chr1:227183022 C/T cg10327440 chr1:227177885 CDC42BPA -1.02 -20.65 -0.75 2.33e-61 Myeloid white cell count; CRC trans rs587242 1.000 rs722155 chr1:96906374 A/G cg10631902 chr5:14652156 NA 0.44 6.84 0.35 3.84e-11 Body mass index (joint analysis main effects and physical activity interaction);Body mass index in physically inactive individuals;Body mass index; CRC cis rs826838 0.967 rs1684414 chr12:39129553 A/G cg26384229 chr12:38710491 ALG10B -0.64 -9.67 -0.47 1.21e-19 Heart rate; CRC trans rs8002861 0.846 rs12428112 chr13:44475821 C/A cg12856521 chr11:46389249 DGKZ -0.43 -6.87 -0.35 3.24e-11 Leprosy; CRC cis rs9611565 0.512 rs139572 chr22:42214532 C/T cg03806693 chr22:41940476 POLR3H -1.03 -11.14 -0.52 1.09e-24 Vitiligo; CRC cis rs1322512 1.000 rs1290296 chr6:153010088 A/C cg03415253 chr6:152958462 SYNE1 0.4 6.04 0.32 4.14e-9 Tonometry; CRC cis rs4862750 0.872 rs6836781 chr4:187899701 G/A cg03452623 chr4:187889614 NA -0.92 -22.45 -0.78 2.37e-68 Lobe attachment (rater-scored or self-reported); CRC cis rs939658 1.000 rs8031504 chr15:79458589 G/T cg17916960 chr15:79447300 NA 0.44 7.08 0.36 8.54e-12 Refractive error; CRC cis rs4938330 0.680 rs4938329 chr11:116928112 C/T cg20608306 chr11:116969690 SIK3 -0.34 -6.58 -0.34 1.86e-10 Blood protein levels; CRC cis rs9527 0.590 rs2148200 chr10:104879847 C/A cg15744005 chr10:104629667 AS3MT -0.31 -6.1 -0.32 3.05e-9 Arsenic metabolism; CRC cis rs1969363 0.509 rs8189633 chr12:38065155 C/G cg26384229 chr12:38710491 ALG10B 0.69 9.17 0.45 5.4e-18 Morning vs. evening chronotype; CRC cis rs5758511 0.689 rs17478227 chr22:42654327 C/G cg00645731 chr22:42541494 CYP2D7P1 -0.68 -8.7 -0.43 1.65e-16 Birth weight; CRC cis rs3096299 0.933 rs28608022 chr16:89454292 C/T cg01788221 chr16:89496183 ANKRD11 -0.42 -6.45 -0.34 3.97e-10 Multiple myeloma (IgH translocation); CRC cis rs2243480 0.803 rs36127118 chr7:65565505 A/G cg25985355 chr7:65971099 NA -0.47 -5.65 -0.3 3.54e-8 Diabetic kidney disease; CRC cis rs9303280 0.806 rs12936409 chr17:38043649 C/T cg17467752 chr17:38218738 THRA -0.38 -5.61 -0.3 4.32e-8 Self-reported allergy; CRC cis rs863345 0.604 rs11265016 chr1:158503785 C/T cg12129480 chr1:158549410 OR10X1 -0.3 -6.27 -0.33 1.12e-9 Pneumococcal bacteremia; CRC cis rs9443645 0.901 rs1567167 chr6:79553827 C/T cg11833968 chr6:79620685 NA -0.35 -6.15 -0.32 2.2e-9 Intelligence (multi-trait analysis); CRC cis rs6585424 1.000 rs12763392 chr10:81934995 C/T cg11900509 chr10:81946545 ANXA11 0.75 9.11 0.45 8.38e-18 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs9311474 0.508 rs12629701 chr3:52619836 T/C cg10802521 chr3:52805072 NEK4 -0.56 -8.77 -0.44 9.84e-17 Electroencephalogram traits; CRC cis rs9309473 0.583 rs6713196 chr2:73576405 T/C cg20560298 chr2:73613845 ALMS1 -0.5 -6.79 -0.35 5.1e-11 Metabolite levels; CRC cis rs2278034 0.578 rs881753 chr3:195606770 C/T cg00031303 chr3:195681400 NA -0.41 -5.9 -0.31 8.8e-9 Bronchopulmonary dysplasia; CRC cis rs875971 0.619 rs2302918 chr7:66000932 A/G cg00343986 chr7:65444356 GUSB 0.51 7.58 0.39 3.57e-13 Aortic root size; CRC cis rs12594515 1.000 rs8039974 chr15:45986665 A/G cg06207120 chr15:45996521 NA 0.32 7.75 0.39 1.15e-13 Waist circumference;Weight; CRC cis rs2251381 0.808 rs7364112 chr21:30548968 C/A cg08807101 chr21:30365312 RNF160 0.66 9.76 0.47 6.3e-20 Selective IgA deficiency; CRC trans rs1814175 0.645 rs7395438 chr11:49877379 G/T cg03929089 chr4:120376271 NA -0.9 -15.52 -0.65 3.9e-41 Height; CRC cis rs739401 0.527 rs423236 chr11:3065916 C/T cg25174290 chr11:3078921 CARS 0.49 7.43 0.38 9.49e-13 Longevity; CRC cis rs801193 0.569 rs3846973 chr7:66120035 T/C cg18252515 chr7:66147081 NA 0.44 6.2 0.32 1.72e-9 Aortic root size; CRC cis rs10504229 0.683 rs6999351 chr8:58127227 C/T cg05313129 chr8:58192883 C8orf71 -0.43 -6.11 -0.32 2.74e-9 Developmental language disorder (linguistic errors); CRC cis rs6604026 0.656 rs2774949 chr1:93352553 T/C cg17283838 chr1:93427260 FAM69A -0.43 -5.79 -0.3 1.61e-8 Multiple sclerosis; CRC cis rs7246657 0.882 rs4803539 chr19:37897522 A/C cg23950597 chr19:37808831 NA -0.48 -5.88 -0.31 1.02e-8 Coronary artery calcification; CRC cis rs9469578 1.000 rs73743323 chr6:33705355 C/T cg18708504 chr6:33715942 IP6K3 0.62 6.98 0.36 1.59e-11 Phosphorus levels; CRC cis rs501120 0.564 rs11598314 chr10:44685795 A/G cg09554077 chr10:44749378 NA 0.55 7.63 0.39 2.51e-13 Coronary artery disease;Coronary heart disease; CRC trans rs66573146 0.572 rs73199995 chr4:6955801 G/C cg07817883 chr1:32538562 TMEM39B 1.1 11.88 0.55 2.44e-27 Granulocyte percentage of myeloid white cells; CRC cis rs7020830 0.894 rs28766572 chr9:37093872 G/T cg14294708 chr9:37120828 ZCCHC7 1.1 22.83 0.78 8.42e-70 Schizophrenia; CRC trans rs12702919 0.714 rs11771608 chr7:9550414 T/C cg15597424 chr4:24472487 NA -0.39 -6.01 -0.31 4.8e-9 PR interval in Tripanosoma cruzi seropositivity; CRC cis rs832187 0.813 rs704368 chr3:63868337 C/T cg16258503 chr3:63850278 ATXN7;THOC7 0.4 5.72 0.3 2.41e-8 Schizophrenia; CRC cis rs2730260 0.537 rs55662704 chr7:158864184 T/C cg02254261 chr7:158964346 NA -0.54 -6.25 -0.33 1.26e-9 Myopia (pathological); CRC cis rs10089 1.000 rs3805606 chr5:127470813 A/C cg25462716 chr5:127418816 SLC12A2;FLJ33630 -0.71 -10.08 -0.49 5.24e-21 Ileal carcinoids; CRC cis rs8031584 0.678 rs4779497 chr15:31151365 T/A cg14829155 chr15:31115871 NA -0.65 -10.19 -0.49 2.28e-21 Huntington's disease progression; CRC cis rs10540 1.000 rs12419716 chr11:503385 C/G cg03576123 chr11:487126 PTDSS2 -1.04 -10.79 -0.51 1.91e-23 Body mass index; CRC cis rs875971 1.000 rs2077593 chr7:65892530 A/G cg18876405 chr7:65276391 NA 0.53 9.01 0.44 1.73e-17 Aortic root size; CRC cis rs10504229 1.000 rs67236942 chr8:58176525 T/C cg02725872 chr8:58115012 NA -0.38 -6.43 -0.33 4.44e-10 Developmental language disorder (linguistic errors); CRC cis rs10804591 0.524 rs2811462 chr3:129303436 T/G cg21885638 chr3:129306552 PLXND1 -0.5 -7.11 -0.37 7.21e-12 Waist-hip ratio;Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Hip circumference adjusted for BMI;Waist-to-hip ratio adjusted for body mass index; CRC cis rs951366 0.789 rs1775154 chr1:205696615 T/A cg14159672 chr1:205819179 PM20D1 0.72 10.6 0.5 9.11e-23 Menarche (age at onset); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg27313501 chr16:2034198 GFER 0.47 6.59 0.34 1.76e-10 Response to antipsychotic treatment; CRC cis rs4930103 0.534 rs2063550 chr11:1979223 G/C cg23202291 chr11:1979235 NA 0.6 8.96 0.44 2.55e-17 DNA methylation (parent-of-origin);DNA methylation (variation); CRC cis rs7618915 0.547 rs34537256 chr3:52657472 A/G cg11645453 chr3:52864694 ITIH4 0.36 6.39 0.33 5.61e-10 Bipolar disorder; CRC cis rs8180040 1.000 rs11130127 chr3:47398793 C/G cg27129171 chr3:47204927 SETD2 -0.65 -10.19 -0.49 2.17e-21 Colorectal cancer; CRC cis rs3733585 0.699 rs7657340 chr4:9966772 A/T cg11266682 chr4:10021025 SLC2A9 -0.46 -9.35 -0.46 1.35e-18 Cleft plate (environmental tobacco smoke interaction); CRC cis rs4319547 0.656 rs10846664 chr12:122823777 C/T cg23029597 chr12:123009494 RSRC2 0.53 6.58 0.34 1.83e-10 Body mass index; CRC cis rs1448094 0.967 rs6539934 chr12:86343973 G/A cg02569458 chr12:86230093 RASSF9 0.38 6.6 0.34 1.66e-10 Major depressive disorder; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg15309264 chr2:58274034 VRK2 0.42 6.02 0.31 4.69e-9 Response to antipsychotic treatment; CRC cis rs473651 0.935 rs515412 chr2:239345394 A/T cg08773314 chr2:239334832 ASB1 0.37 8.49 0.42 7.43e-16 Multiple system atrophy; CRC cis rs11105298 0.891 rs4842661 chr12:89930399 A/G cg00757033 chr12:89920650 WDR51B 0.4 6.46 0.34 3.69e-10 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; CRC cis rs13108904 0.935 rs11247984 chr4:1292811 G/A cg00684032 chr4:1343700 KIAA1530 0.47 6.78 0.35 5.74e-11 Obesity-related traits; CRC cis rs2576037 0.526 rs4890703 chr18:44522037 A/G cg23996704 chr18:44553084 KATNAL2 -0.33 -6.27 -0.33 1.13e-9 Personality dimensions; CRC cis rs7209700 0.662 rs11656865 chr17:45346489 A/G cg17185639 chr17:45330862 ITGB3 0.38 6.09 0.32 3.09e-9 IgG glycosylation; CRC cis rs1167827 1.000 rs1167827 chr7:75163169 A/G cg16384552 chr7:74938386 SPDYE8P -0.51 -7.7 -0.39 1.59e-13 Body mass index;BMI (adjusted for smoking behaviour);BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs7208859 0.673 rs9895815 chr17:29138033 A/G cg13385521 chr17:29058706 SUZ12P 0.73 8.39 0.42 1.43e-15 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs10504229 0.593 rs76118562 chr8:57988110 G/C cg21724239 chr8:58056113 NA 0.77 9.39 0.46 1.03e-18 Developmental language disorder (linguistic errors); CRC cis rs1552244 0.882 rs55962400 chr3:10044457 C/T cg18598329 chr3:10140678 FANCD2;C3orf24 -0.75 -8.95 -0.44 2.69e-17 Alzheimer's disease; CRC cis rs780096 0.526 rs1647267 chr2:27651054 A/T cg24768116 chr2:27665128 KRTCAP3 -0.35 -7.97 -0.4 2.59e-14 Total body bone mineral density; CRC cis rs2871473 1.000 rs1030024 chr2:103105769 A/T cg09003973 chr2:102972529 NA -0.48 -6.32 -0.33 8.28e-10 Blood protein levels; CRC cis rs7107174 1.000 rs11601590 chr11:78073288 T/G cg02023728 chr11:77925099 USP35 0.49 8.61 0.43 3.05e-16 Testicular germ cell tumor; CRC cis rs270601 0.770 rs4361510 chr5:131599647 C/T cg02033258 chr5:131593261 PDLIM4 0.46 8.64 0.43 2.54e-16 Acylcarnitine levels; CRC cis rs60871478 0.735 rs10950455 chr7:831451 C/T cg05535760 chr7:792225 HEATR2 -1.03 -12.21 -0.56 1.59e-28 Cerebrospinal P-tau181p levels; CRC cis rs11229555 0.645 rs11601296 chr11:58423297 A/G cg15696309 chr11:58395628 NA -0.88 -9.19 -0.45 4.6e-18 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; CRC cis rs6840360 0.554 rs10222838 chr4:152690099 T/C cg09659197 chr4:152720779 NA 0.4 8.44 0.42 1.05e-15 Intelligence (multi-trait analysis); CRC cis rs11212617 1.000 rs650173 chr11:108174173 G/A cg14761454 chr11:108092087 ATM;NPAT 0.42 6.36 0.33 6.85e-10 Response to metformin in type 2 diabetes (glycemic); CRC cis rs9479482 0.935 rs9479507 chr6:150366514 T/G cg25797454 chr6:150327115 RAET1K 0.35 6.15 0.32 2.21e-9 Alopecia areata; CRC cis rs6968419 0.747 rs3807968 chr7:115863446 G/A cg02561103 chr7:115862891 TES -0.43 -6.45 -0.33 4.1e-10 Intraocular pressure; CRC cis rs758324 0.947 rs6861732 chr5:131156462 A/C cg25547332 chr5:131281432 NA 0.39 5.69 0.3 2.79e-8 Alzheimer's disease in APOE e4- carriers; CRC cis rs72634258 0.786 rs4268374 chr1:8174083 G/T cg00042356 chr1:8021962 PARK7 -0.5 -5.84 -0.31 1.25e-8 Inflammatory bowel disease; CRC cis rs11608355 0.515 rs3742018 chr12:109949134 C/T cg05360138 chr12:110035743 NA 0.77 8.67 0.43 1.99e-16 Neuroticism; CRC cis rs2836974 0.644 rs9978775 chr21:40694526 A/G cg17971929 chr21:40555470 PSMG1 -0.63 -8.9 -0.44 3.79e-17 Cognitive function; CRC cis rs877282 0.797 rs11253329 chr10:753200 A/T cg17470449 chr10:769945 NA 0.61 7.96 0.4 2.78e-14 Uric acid levels; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg03393821 chr1:145610981 POLR3C;RNF115 0.47 7.38 0.38 1.27e-12 Liver disease severity in Alagille syndrome; CRC cis rs789852 0.867 rs1773177 chr3:194316181 A/C cg21106136 chr3:194405973 FAM43A -0.72 -6.0 -0.31 5.28e-9 QT interval; CRC cis rs72634258 0.945 rs161800 chr1:8042402 A/T cg00042356 chr1:8021962 PARK7 0.62 7.15 0.37 5.53e-12 Inflammatory bowel disease; CRC cis rs10782582 0.593 rs17647178 chr1:76210524 A/G cg03433033 chr1:76189801 ACADM -0.44 -6.54 -0.34 2.31e-10 Daytime sleep phenotypes; CRC cis rs5745709 0.861 rs5745676 chr7:81372156 A/G cg18944653 chr7:81381353 HGF -0.29 -5.62 -0.3 3.99e-8 Gout; CRC cis rs7428 0.545 rs7572750 chr2:85552186 C/A cg24342717 chr2:85555507 TGOLN2 -0.76 -12.38 -0.56 3.84e-29 Ear protrusion; CRC cis rs4423214 0.592 rs10898223 chr11:71219264 G/A cg05163923 chr11:71159392 DHCR7 -0.56 -5.83 -0.31 1.33e-8 Vitamin D levels; CRC trans rs11039798 1.000 rs3902927 chr11:48581457 C/T cg03929089 chr4:120376271 NA 0.61 6.06 0.32 3.67e-9 Axial length; CRC cis rs4604732 0.527 rs60444724 chr1:247623164 T/G cg12758973 chr1:247694275 LOC148824;OR2C3 0.45 6.4 0.33 5.2e-10 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CRC cis rs4481887 0.962 rs4244177 chr1:248468279 C/T cg00666640 chr1:248458726 OR2T12 0.52 9.16 0.45 5.86e-18 Common traits (Other); CRC cis rs728616 0.867 rs61860039 chr10:81939906 G/A cg11900509 chr10:81946545 ANXA11 -0.71 -7.16 -0.37 5.2e-12 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs7487075 0.820 rs7315493 chr12:46689427 G/A cg22049899 chr12:47219821 SLC38A4 0.32 5.82 0.31 1.38e-8 Itch intensity from mosquito bite; CRC cis rs873946 0.517 rs7071784 chr10:134559980 T/C cg27286337 chr10:134555280 INPP5A 0.67 8.85 0.44 5.68e-17 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg04071446 chr10:115933849 C10orf118 0.48 6.21 0.32 1.61e-9 Thyroid stimulating hormone; CRC cis rs1150668 0.796 rs728122 chr6:28399124 G/A cg03623178 chr6:28175578 NA 0.48 7.09 0.36 8.19e-12 Pubertal anthropometrics; CRC cis rs992157 0.798 rs10932772 chr2:219177148 C/T cg04880052 chr2:219191631 PNKD 0.4 6.38 0.33 6.13e-10 Colorectal cancer; CRC cis rs7937682 0.924 rs875257 chr11:111530453 A/G cg19812747 chr11:111475976 SIK2 -0.58 -10.08 -0.49 5.38e-21 Primary sclerosing cholangitis; CRC cis rs769267 0.896 rs11882123 chr19:19386339 A/G cg20644253 chr19:19431407 KIAA0892;SF4 0.43 5.97 0.31 6e-9 Tonsillectomy; CRC cis rs1552244 1.000 rs6414438 chr3:10073824 G/C cg16606324 chr3:10149918 C3orf24 0.69 9.48 0.46 5.29e-19 Alzheimer's disease; CRC trans rs7937682 1.000 rs7128353 chr11:111538875 A/G cg18187862 chr3:45730750 SACM1L 0.49 7.23 0.37 3.4e-12 Primary sclerosing cholangitis; CRC trans rs6951245 1.000 rs11766526 chr7:1101433 G/A cg13565492 chr6:43139072 SRF -0.72 -7.44 -0.38 8.63e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs7618501 0.633 rs2856234 chr3:50139142 A/G cg24110177 chr3:50126178 RBM5 0.5 7.86 0.4 5.58e-14 Intelligence (multi-trait analysis); CRC cis rs6840360 0.967 rs7695162 chr4:152510541 G/A cg09659197 chr4:152720779 NA 0.5 10.56 0.5 1.21e-22 Intelligence (multi-trait analysis); CRC cis rs9788333 0.707 rs12584557 chr13:21886171 C/A cg25811766 chr13:21894605 NA 0.68 10.86 0.51 1.14e-23 Thiazide-induced adverse metabolic effects in hypertensive patients; CRC trans rs1005277 0.522 rs7090858 chr10:38003670 A/C cg23533926 chr12:111358616 MYL2 0.45 6.57 0.34 1.99e-10 Extrinsic epigenetic age acceleration; CRC cis rs8060686 0.858 rs2271294 chr16:67902326 A/T cg26727032 chr16:67993705 SLC12A4 -0.71 -11.74 -0.54 8.32e-27 HDL cholesterol;Metabolic syndrome; CRC cis rs735396 0.595 rs1169279 chr12:121455873 C/T cg02403541 chr12:121454288 C12orf43 0.58 9.16 0.45 5.55e-18 N-glycan levels; CRC cis rs9463078 0.817 rs3799967 chr6:44798701 A/G cg25276700 chr6:44698697 NA -0.26 -6.28 -0.33 1.09e-9 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; CRC cis rs950169 1.000 rs950169 chr15:84706461 C/T cg24253500 chr15:84953950 NA 0.38 6.36 0.33 6.87e-10 Schizophrenia; CRC cis rs1728785 0.748 rs889560 chr16:68605784 A/G cg02972257 chr16:68554789 NA -0.6 -7.52 -0.38 5.1e-13 Ulcerative colitis; CRC cis rs7953508 0.741 rs1498706 chr12:93996980 C/T cg18151635 chr12:93972918 NA -0.47 -7.02 -0.36 1.29e-11 Pubertal anthropometrics; CRC cis rs7044106 0.791 rs10818473 chr9:123484155 A/C cg09419670 chr9:123605666 PSMD5;LOC253039 0.79 12.97 0.58 2.29e-31 Hip circumference adjusted for BMI; CRC cis rs853679 0.517 rs2273564 chr6:28057594 A/T cg21251018 chr6:28226885 NKAPL 0.48 6.22 0.32 1.55e-9 Depression; CRC trans rs2303319 0.504 rs62188990 chr2:162540635 G/A cg15664909 chr17:685709 GLOD4;RNMTL1 -0.68 -5.99 -0.31 5.38e-9 Cognitive function; CRC cis rs2481665 0.608 rs2476194 chr1:62594593 C/T cg18591186 chr1:62594603 INADL -0.8 -13.25 -0.59 2.05e-32 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg20560186 chr6:109804103 ZBTB24 -0.39 -5.97 -0.31 6.29e-9 Liver disease severity in Alagille syndrome; CRC cis rs6761276 0.899 rs12466799 chr2:113835999 T/C cg24553058 chr2:113831203 IL1F10 0.39 6.31 0.33 9.19e-10 Protein quantitative trait loci; CRC trans rs72956618 0.715 rs72933222 chr2:207319653 C/T cg16073378 chr2:468413 NA -0.65 -6.42 -0.33 4.86e-10 Tonsillectomy; CRC cis rs1005277 0.579 rs1780137 chr10:38501475 C/G cg25517755 chr10:38738941 LOC399744 -0.42 -5.94 -0.31 7.22e-9 Extrinsic epigenetic age acceleration; CRC cis rs763121 0.853 rs8138996 chr22:39047435 G/T cg06022373 chr22:39101656 GTPBP1 0.78 12.39 0.56 3.54e-29 Menopause (age at onset); CRC cis rs3760982 1.000 rs4802200 chr19:44289518 G/A cg12072164 chr19:44306565 LYPD5 0.4 6.19 0.32 1.75e-9 Breast cancer (estrogen-receptor negative);Breast cancer; CRC cis rs2243480 1.000 rs316334 chr7:65602126 G/T cg12463550 chr7:65579703 CRCP 0.7 6.48 0.34 3.32e-10 Diabetic kidney disease; CRC cis rs7086627 0.515 rs4934189 chr10:82214792 C/T cg00277334 chr10:82204260 NA -0.82 -15.82 -0.66 2.64e-42 Post bronchodilator FEV1; CRC cis rs7216064 1.000 rs56404791 chr17:65893019 T/G cg12091567 chr17:66097778 LOC651250 -0.63 -7.82 -0.4 7.23e-14 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CRC cis rs67311347 1.000 rs4973994 chr3:40453024 T/C cg09455208 chr3:40491958 NA 0.48 9.21 0.45 3.8e-18 Renal cell carcinoma; CRC cis rs11758351 0.660 rs11753131 chr6:26219384 G/A cg10723962 chr6:26240782 HIST1H4F -0.38 -6.09 -0.32 3.14e-9 Gout;Renal underexcretion gout; CRC cis rs6502050 0.805 rs11077970 chr17:80085916 C/T cg11859384 chr17:80120422 CCDC57 0.37 5.73 0.3 2.22e-8 Life satisfaction; CRC cis rs3749237 0.595 rs35701831 chr3:49515000 A/C cg03060546 chr3:49711283 APEH 0.66 11.06 0.52 2.19e-24 Resting heart rate; CRC trans rs13315871 0.929 rs17059171 chr3:58302586 A/G cg23976632 chr12:120875743 COX6A1 0.64 6.07 0.32 3.53e-9 Cholesterol, total; CRC cis rs1129187 0.755 rs9471985 chr6:42941324 T/C cg27588902 chr6:42928151 GNMT -0.4 -7.26 -0.37 2.73e-12 Alzheimer's disease in APOE e4+ carriers; CRC cis rs7178572 0.633 rs907369 chr15:77843560 A/G cg22256960 chr15:77711686 NA -0.63 -8.99 -0.44 2.04e-17 Type 2 diabetes; CRC cis rs28386778 0.897 rs894408 chr17:61896814 C/T cg06873352 chr17:61820015 STRADA 0.77 14.46 0.62 5e-37 Prudent dietary pattern; CRC cis rs7927592 0.913 rs67947146 chr11:68314980 C/T cg01657329 chr11:68192670 LRP5 -0.46 -6.65 -0.34 1.22e-10 Total body bone mineral density; CRC cis rs6547741 1.000 rs10165098 chr2:27796526 C/T cg27432699 chr2:27873401 GPN1 0.76 13.58 0.6 1.2e-33 Oral cavity cancer; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg23659015 chr14:35099524 SNX6 0.43 6.17 0.32 2.02e-9 Response to antipsychotic treatment; CRC cis rs4478858 0.684 rs7544946 chr1:31749736 T/C cg00250761 chr1:31883323 NA -0.43 -8.37 -0.42 1.68e-15 Alcohol dependence; CRC cis rs919433 0.680 rs67580728 chr2:198431258 C/T cg10820045 chr2:198174542 NA 0.41 6.94 0.36 2.09e-11 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC cis rs7523050 0.643 rs34920128 chr1:109400889 C/T cg08274380 chr1:109419600 GPSM2 0.84 6.6 0.34 1.69e-10 Fat distribution (HIV); CRC cis rs8060686 0.641 rs76646352 chr16:68044797 C/A cg26727032 chr16:67993705 SLC12A4 -0.56 -6.22 -0.32 1.53e-9 HDL cholesterol;Metabolic syndrome; CRC trans rs2303319 0.504 rs58622044 chr2:162596287 A/G cg13490827 chr1:46269305 MAST2 -0.69 -6.05 -0.32 4.03e-9 Cognitive function; CRC cis rs2404602 0.735 rs1607017 chr15:76726465 G/T cg03037974 chr15:76606532 NA -0.53 -7.68 -0.39 1.89e-13 Blood metabolite levels; CRC cis rs9311474 0.607 rs28661185 chr3:52567188 G/T cg18404041 chr3:52824283 ITIH1 -0.36 -7.31 -0.37 1.99e-12 Electroencephalogram traits; CRC cis rs6674970 1.000 rs4970941 chr1:151068546 A/G cg03258749 chr1:151040405 MLLT11 -0.47 -7.28 -0.37 2.55e-12 Childhood ear infection; CRC cis rs3785574 0.962 rs4968660 chr17:61792221 G/A cg06601766 chr17:61851465 DDX42;CCDC47 0.58 8.31 0.42 2.54e-15 Height; CRC cis rs933688 0.938 rs7705465 chr5:90680949 G/A cg02339078 chr5:90679543 LOC100129716;ARRDC3 0.92 13.87 0.61 9.28e-35 Smoking behavior; CRC cis rs7147624 1.000 rs11848209 chr14:66022832 T/A cg03016385 chr14:66212404 NA -1.05 -10.9 -0.52 7.87e-24 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs10191773 0.584 rs72831633 chr2:112945932 T/G cg04979063 chr2:113191202 RGPD5;RGPD8 0.65 5.74 0.3 2.15e-8 Yeast infection; CRC cis rs9287719 1.000 rs9287719 chr2:10710730 C/T cg00105475 chr2:10696890 NA 0.47 7.54 0.38 4.64e-13 Prostate cancer; CRC cis rs10870270 1.000 rs10870292 chr10:133770782 G/C cg17892150 chr10:133769511 PPP2R2D -0.75 -11.13 -0.52 1.25e-24 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; CRC cis rs1552244 1.000 rs61077902 chr3:10126153 T/G cg02579736 chr3:10068473 FANCD2;CIDECP 0.98 13.22 0.59 2.64e-32 Alzheimer's disease; CRC cis rs6901250 1.000 rs615199 chr6:117113653 T/C cg12892004 chr6:117198278 RFX6 0.41 6.4 0.33 5.43e-10 C-reactive protein levels; CRC cis rs9486719 1.000 rs12207570 chr6:96987884 A/C cg18709589 chr6:96969512 KIAA0776 -0.53 -6.03 -0.32 4.37e-9 Migraine;Coronary artery disease; CRC cis rs651907 0.535 rs13059470 chr3:101424800 A/G cg03837452 chr3:101395095 ZBTB11;LOC100009676 -0.57 -7.79 -0.39 8.71e-14 Colorectal cancer; CRC trans rs55675132 0.548 rs75733320 chr1:115373820 T/C cg25493687 chr8:27288214 PTK2B 0.5 6.17 0.32 1.96e-9 Schizophrenia; CRC cis rs9311676 0.656 rs11712213 chr3:58384995 G/A cg06643156 chr3:58380774 PXK 0.41 6.33 0.33 7.82e-10 Systemic lupus erythematosus; CRC cis rs3806843 0.966 rs10053945 chr5:140160127 C/T cg16607685 chr5:140181889 PCDHA2;PCDHA1;PCDHA3 -0.27 -6.25 -0.33 1.25e-9 Depressive symptoms (multi-trait analysis); CRC cis rs796364 1.000 rs281759 chr2:200787719 T/C cg25936922 chr2:200820526 C2orf60;C2orf47 0.7 7.65 0.39 2.21e-13 Schizophrenia; CRC cis rs7944584 0.563 rs2280231 chr11:47600438 C/T cg20307385 chr11:47447363 PSMC3 0.82 11.77 0.54 6.14e-27 Fasting blood glucose;Fasting blood glucose (BMI interaction); CRC cis rs7107174 0.688 rs2063725 chr11:78133452 T/G cg02023728 chr11:77925099 USP35 0.35 5.93 0.31 7.75e-9 Testicular germ cell tumor; CRC cis rs651907 0.535 rs13059470 chr3:101424800 A/G cg12386194 chr3:101231763 SENP7 -0.5 -7.48 -0.38 6.71e-13 Colorectal cancer; CRC cis rs4700695 0.697 rs2561240 chr5:65235310 T/C cg21114390 chr5:65439923 SFRS12 0.63 6.44 0.33 4.3e-10 Facial morphology (factor 19); CRC cis rs13108904 0.517 rs13128825 chr4:1334007 G/A cg15763984 chr4:1342303 KIAA1530 0.44 6.79 0.35 5.24e-11 Obesity-related traits; CRC cis rs7814319 0.933 rs13261747 chr8:97238769 A/G cg20787634 chr8:97240163 UQCRB -0.53 -9.46 -0.46 5.96e-19 Lung function (FVC); CRC cis rs10779751 1.000 rs11121703 chr1:11293792 G/T cg08854313 chr1:11322531 MTOR -0.66 -9.57 -0.47 2.72e-19 Body mass index; CRC cis rs7044106 0.648 rs2031369 chr9:123360294 G/A cg09586646 chr9:123605570 PSMD5;LOC253039 0.52 7.52 0.38 5.12e-13 Hip circumference adjusted for BMI; CRC cis rs9378357 0.850 rs9391986 chr6:3290583 A/G cg08754725 chr6:3293098 SLC22A23 0.8 7.55 0.38 4.19e-13 Obesity-related traits; CRC cis rs8141529 0.644 rs5752795 chr22:29178820 T/C cg02153584 chr22:29168773 CCDC117 0.54 8.02 0.4 1.84e-14 Lymphocyte counts; CRC cis rs897984 0.644 rs73524556 chr16:30823162 G/A cg02466173 chr16:30829666 NA -0.85 -15.15 -0.64 1.03e-39 Dementia with Lewy bodies; CRC cis rs2075371 0.966 rs1619682 chr7:133996703 T/G cg11752832 chr7:134001865 SLC35B4 0.49 7.59 0.39 3.36e-13 Mean platelet volume; CRC trans rs2243480 1.000 rs34637256 chr7:65360131 G/A cg10756647 chr7:56101905 PSPH 0.73 7.72 0.39 1.46e-13 Diabetic kidney disease; CRC cis rs9457247 0.765 rs9295385 chr6:167448181 A/G cg07741184 chr6:167504864 NA 0.35 6.07 0.32 3.53e-9 Crohn's disease; CRC cis rs12681288 0.823 rs2701903 chr8:1004029 A/G cg08648136 chr8:956695 NA -0.29 -6.14 -0.32 2.44e-9 Schizophrenia; CRC cis rs6743376 0.556 rs1530550 chr2:113817513 A/T cg09040174 chr2:113837401 NA 0.42 6.23 0.32 1.45e-9 Inflammatory biomarkers; CRC cis rs1865760 0.613 rs2071300 chr6:25914572 C/T cg03264133 chr6:25882463 NA -0.46 -6.83 -0.35 4.03e-11 Height; CRC cis rs898097 0.841 rs8180 chr17:80901036 C/G cg15369054 chr17:80825471 TBCD -0.52 -8.47 -0.42 8.18e-16 Breast cancer; CRC cis rs9393692 0.620 rs9358916 chr6:26283185 G/A cg13736514 chr6:26305472 NA -0.44 -7.37 -0.38 1.41e-12 Educational attainment; CRC cis rs80207740 0.941 rs2076940 chr8:21836020 A/G cg12468850 chr8:21767224 DOK2 -0.57 -6.28 -0.33 1.07e-9 Mean corpuscular hemoglobin; CRC cis rs11098499 1.000 rs10029750 chr4:120172543 A/G cg09307838 chr4:120376055 NA 0.62 9.6 0.47 2.12e-19 Corneal astigmatism; CRC cis rs7901135 0.962 rs4245601 chr10:60567581 C/G cg23799393 chr10:60588674 BICC1 0.37 5.71 0.3 2.53e-8 Morning vs. evening chronotype; CRC cis rs9372498 0.505 rs62424173 chr6:118780507 C/G cg18833306 chr6:118973337 C6orf204 0.45 5.82 0.31 1.44e-8 Diastolic blood pressure; CRC trans rs3780486 0.757 rs10813949 chr9:33123464 G/A cg04842962 chr6:43655489 MRPS18A 1.16 25.8 0.82 5.09e-81 IgG glycosylation; CRC cis rs3106136 0.967 rs3113862 chr4:95143122 A/G cg11021082 chr4:95130006 SMARCAD1 -0.47 -7.38 -0.38 1.3e-12 Capecitabine sensitivity; CRC cis rs870825 0.616 rs7682677 chr4:185640717 C/G cg04058563 chr4:185651563 MLF1IP 0.74 9.69 0.47 1.07e-19 Blood protein levels; CRC cis rs9733 0.650 rs9803935 chr1:150552622 T/G cg13175981 chr1:150552382 MCL1 0.39 5.63 0.3 3.78e-8 Tonsillectomy; CRC cis rs9549260 0.755 rs9549236 chr13:41147158 C/T cg21288729 chr13:41239152 FOXO1 -0.42 -6.43 -0.33 4.58e-10 Red blood cell count; CRC trans rs11148252 0.514 rs9526843 chr13:52730056 C/T cg18335740 chr13:41363409 SLC25A15 0.47 6.95 0.36 1.99e-11 Lewy body disease; CRC cis rs172166 0.561 rs149973 chr6:27983613 G/T cg15845792 chr6:28175446 NA 0.63 9.46 0.46 6.31e-19 Cardiac Troponin-T levels; CRC cis rs17253792 0.822 rs2147114 chr14:56077118 C/T cg01858014 chr14:56050164 KTN1 -0.87 -7.23 -0.37 3.34e-12 Putamen volume; CRC cis rs172166 0.694 rs536704 chr6:28092603 T/G cg10876282 chr6:28092338 ZSCAN16 0.48 6.58 0.34 1.85e-10 Cardiac Troponin-T levels; CRC cis rs9733 0.818 rs11204695 chr1:150657011 T/G cg17724175 chr1:150552817 MCL1 -0.46 -7.22 -0.37 3.54e-12 Tonsillectomy; CRC cis rs11997175 0.902 rs7462610 chr8:33693318 A/T ch.8.33884649F chr8:33765107 NA 0.45 6.58 0.34 1.83e-10 Body mass index; CRC cis rs12701220 0.522 rs868833 chr7:1054973 C/G cg02869364 chr7:1081709 C7orf50 -0.39 -5.63 -0.3 3.87e-8 Bronchopulmonary dysplasia; CRC cis rs10504229 0.593 rs76922080 chr8:57985837 C/G cg02725872 chr8:58115012 NA -0.53 -7.18 -0.37 4.55e-12 Developmental language disorder (linguistic errors); CRC cis rs6838801 0.892 rs56248930 chr4:77534438 A/T cg17476223 chr4:77663285 SHROOM3 0.44 6.07 0.32 3.59e-9 Cleft lip with or without cleft palate; CRC cis rs875971 1.000 rs12533997 chr7:65965377 A/G cg18912574 chr7:65842487 NCRNA00174 0.35 6.09 0.32 3.11e-9 Aortic root size; CRC cis rs17001868 0.568 rs6001894 chr22:40779197 T/C cg07138101 chr22:40742427 ADSL 0.53 7.32 0.37 1.97e-12 Mammographic density (dense area); CRC cis rs4713118 0.955 rs9380012 chr6:27684654 A/G cg12172441 chr6:28176163 NA 0.47 6.19 0.32 1.75e-9 Parkinson's disease; CRC cis rs9487051 0.752 rs9372209 chr6:109601684 T/C cg01475377 chr6:109611718 NA -0.39 -6.67 -0.35 1.05e-10 Reticulocyte fraction of red cells; CRC cis rs728616 0.681 rs17677908 chr10:82049603 A/G cg05935833 chr10:81318306 SFTPA2 -0.61 -7.1 -0.36 7.84e-12 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs875971 0.862 rs778707 chr7:65857027 G/A cg12463550 chr7:65579703 CRCP 0.48 6.52 0.34 2.72e-10 Aortic root size; CRC cis rs798554 0.724 rs798498 chr7:2795882 T/G cg04166393 chr7:2884313 GNA12 0.5 7.18 0.37 4.71e-12 Height; CRC cis rs4481887 1.000 rs6697863 chr1:248495588 G/A cg13385794 chr1:248469461 NA 0.39 6.68 0.35 9.97e-11 Common traits (Other); CRC trans rs1005277 0.540 rs2474598 chr10:38430296 C/T cg23533926 chr12:111358616 MYL2 0.52 7.74 0.39 1.21e-13 Extrinsic epigenetic age acceleration; CRC trans rs4378999 0.748 rs6775666 chr3:51703064 A/G cg18840832 chr19:44079285 XRCC1 -0.6 -6.0 -0.31 5.17e-9 Waist circumference adjusted for BMI in non-smokers;Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction); CRC cis rs1801251 0.963 rs13424351 chr2:233573629 A/G cg25237894 chr2:233734115 C2orf82 0.47 7.44 0.38 9e-13 Coronary artery disease; CRC cis rs6565180 0.926 rs4788409 chr16:30393771 G/A cg01392867 chr16:30410429 ZNF48 0.38 6.1 0.32 3e-9 Tonsillectomy; CRC cis rs1046896 0.519 rs9900369 chr17:80829807 G/A cg17346650 chr17:80929145 B3GNTL1 0.49 7.25 0.37 3.05e-12 Glycated hemoglobin levels; CRC cis rs12474201 0.963 rs11676737 chr2:46929873 T/C cg06386533 chr2:46925753 SOCS5 0.8 13.15 0.59 4.87e-32 Height; CRC cis rs9443645 0.836 rs9352676 chr6:79629999 A/G cg09184832 chr6:79620586 NA -0.51 -9.57 -0.47 2.65e-19 Intelligence (multi-trait analysis); CRC cis rs6912958 0.559 rs395358 chr6:88057924 T/C cg08069147 chr6:88032118 GJB7;C6orf162 0.68 11.1 0.52 1.52e-24 Monocyte percentage of white cells; CRC cis rs2933343 0.661 rs2630259 chr3:128606322 C/T cg25356066 chr3:128598488 ACAD9 0.39 5.66 0.3 3.22e-8 IgG glycosylation; CRC cis rs2795502 0.630 rs4948698 chr10:43539459 A/G cg20628663 chr10:43360327 NA -0.5 -6.12 -0.32 2.66e-9 Blood protein levels; CRC trans rs116095464 0.558 rs6555055 chr5:226160 A/C cg00938859 chr5:1591904 SDHAP3 0.69 7.55 0.38 4.21e-13 Breast cancer; CRC trans rs116966368 0.602 rs1785800 chr18:26281282 A/T cg26893861 chr17:41843967 DUSP3 0.54 6.07 0.32 3.43e-9 Neuroticism; CRC cis rs9916302 0.904 rs12452880 chr17:37591149 G/C cg07936489 chr17:37558343 FBXL20 -0.79 -12.05 -0.55 5.82e-28 Glomerular filtration rate (creatinine); CRC cis rs13256369 1.000 rs885000 chr8:8568875 G/T cg06671706 chr8:8559999 CLDN23 0.61 9.1 0.45 8.97e-18 Obesity-related traits; CRC cis rs2535633 0.820 rs7626551 chr3:52938092 C/G cg18099408 chr3:52552593 STAB1 0.35 5.88 0.31 9.97e-9 Body mass index; CRC cis rs9399135 0.967 rs11755229 chr6:135369913 A/G cg24558204 chr6:135376177 HBS1L 0.49 7.72 0.39 1.41e-13 Red blood cell count; CRC cis rs6772849 0.930 rs13434160 chr3:128374770 T/C cg08795948 chr3:128337044 NA 0.36 6.28 0.33 1.06e-9 Monocyte percentage of white cells;Monocyte count; CRC cis rs763121 0.853 rs2294296 chr22:39053049 T/C cg06022373 chr22:39101656 GTPBP1 0.78 12.39 0.56 3.43e-29 Menopause (age at onset); CRC cis rs864537 0.676 rs2056625 chr1:167420299 G/A cg09179987 chr1:167433047 CD247 0.48 7.1 0.36 7.65e-12 Celiac disease or Rheumatoid arthritis;Celiac disease; CRC cis rs9527 0.590 rs7087459 chr10:104790999 T/C cg15744005 chr10:104629667 AS3MT -0.31 -6.21 -0.32 1.59e-9 Arsenic metabolism; CRC trans rs1412337 1.000 rs909947 chr1:168615756 G/A cg03540912 chr16:71792711 SNORD71;AP1G1 0.53 6.11 0.32 2.84e-9 Morbidity-free survival; CRC cis rs1799949 0.965 rs1842147 chr17:41435192 C/T cg23758822 chr17:41437982 NA 0.81 13.55 0.6 1.54e-33 Menopause (age at onset); CRC cis rs875971 0.545 rs12673308 chr7:65631361 C/A cg18876405 chr7:65276391 NA 0.44 6.12 0.32 2.67e-9 Aortic root size; CRC cis rs10540 1.000 rs79808876 chr11:465763 C/A cg21784768 chr11:537496 LRRC56 -0.59 -5.61 -0.3 4.27e-8 Body mass index; CRC cis rs8060686 0.641 rs73612690 chr16:68153200 G/A cg26727032 chr16:67993705 SLC12A4 -0.6 -8.11 -0.41 1.04e-14 HDL cholesterol;Metabolic syndrome; CRC cis rs2286885 1.000 rs4837093 chr9:129254443 G/A cg15282417 chr9:129245246 FAM125B 0.44 8.2 0.41 5.43e-15 Intraocular pressure; CRC cis rs7618915 0.547 rs4687638 chr3:52651966 A/C cg15147215 chr3:52552868 STAB1 -0.62 -10.25 -0.49 1.37e-21 Bipolar disorder; CRC cis rs10504229 0.636 rs77753517 chr8:58115897 C/T cg22535103 chr8:58192502 C8orf71 -0.7 -9.34 -0.46 1.47e-18 Developmental language disorder (linguistic errors); CRC cis rs12980942 0.591 rs2304231 chr19:41762670 T/C cg25627403 chr19:41769009 HNRNPUL1 0.56 6.47 0.34 3.49e-10 Coronary artery disease; CRC cis rs503341 0.756 rs626333 chr11:63591861 C/T cg04362095 chr11:63592001 C11orf84 -0.56 -9.18 -0.45 4.9e-18 Pulse pressure; CRC cis rs7772486 0.558 rs9376965 chr6:146130055 G/A cg05347473 chr6:146136440 FBXO30 0.5 7.19 0.37 4.4e-12 Lobe attachment (rater-scored or self-reported); CRC cis rs9322193 0.923 rs10782311 chr6:149943728 A/G cg13206674 chr6:150067644 NUP43 0.64 9.66 0.47 1.32e-19 Lung cancer; CRC cis rs870825 0.616 rs2090589 chr4:185647731 A/G cg04058563 chr4:185651563 MLF1IP 0.72 9.3 0.46 2.04e-18 Blood protein levels; CRC cis rs208520 0.909 rs62414639 chr6:67023706 G/A cg07460842 chr6:66804631 NA 0.84 9.91 0.48 1.98e-20 Exhaled nitric oxide output; CRC cis rs7572644 0.679 rs12986980 chr2:28030437 A/G cg27432699 chr2:27873401 GPN1 0.46 6.18 0.32 1.87e-9 Response to carboplatin and paclitaxel in ovarian cancer (Caspase 3/7 EC50); CRC cis rs6502050 0.835 rs7220639 chr17:80146866 G/A cg13198984 chr17:80129470 CCDC57 0.46 8.15 0.41 7.94e-15 Life satisfaction; CRC cis rs7917772 0.536 rs3961456 chr10:104425304 A/T cg22532475 chr10:104410764 TRIM8 0.37 6.31 0.33 8.95e-10 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC trans rs11068315 1.000 rs11068315 chr12:117510552 A/G cg19846154 chr8:74332112 NA -0.59 -6.14 -0.32 2.4e-9 Pre-treatment pain in head and neck squamous cell carcinoma; CRC cis rs12431939 1.000 rs58225416 chr14:51662196 C/T cg23942311 chr14:51606299 NA -0.54 -6.21 -0.32 1.58e-9 Cancer; CRC cis rs2281845 0.965 rs7516023 chr1:201085521 C/T cg01987224 chr1:201084466 NA 0.53 9.84 0.48 3.46e-20 Permanent tooth development; CRC cis rs9916302 0.904 rs11078910 chr17:37671269 G/T cg15445000 chr17:37608096 MED1 0.43 9.62 0.47 1.78e-19 Glomerular filtration rate (creatinine); CRC cis rs1707322 0.682 rs12037459 chr1:46094959 T/G cg03146154 chr1:46216737 IPP 0.66 9.28 0.46 2.41e-18 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC trans rs6951245 1.000 rs77083167 chr7:1071823 C/T cg13565492 chr6:43139072 SRF -0.71 -7.31 -0.37 2.04e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs1799949 1.000 rs8176109 chr17:41265776 A/G cg01879757 chr17:41196368 BRCA1 -0.43 -6.58 -0.34 1.82e-10 Menopause (age at onset); CRC cis rs1799949 1.000 rs4793189 chr17:41190715 G/A cg25072359 chr17:41440525 NA 0.47 6.92 0.36 2.32e-11 Menopause (age at onset); CRC cis rs1577917 0.958 rs12196230 chr6:86519960 T/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.51 -6.85 -0.35 3.57e-11 Response to antipsychotic treatment; CRC cis rs10463316 0.928 rs4958267 chr5:150752643 A/T cg03212797 chr5:150827313 SLC36A1 -0.53 -8.35 -0.42 1.93e-15 Metabolite levels (Pyroglutamine); CRC cis rs6912958 0.514 rs1980792 chr6:87889917 A/G cg08069147 chr6:88032118 GJB7;C6orf162 -0.71 -11.54 -0.54 4.12e-26 Monocyte percentage of white cells; CRC cis rs11148252 0.744 rs4884354 chr13:53017474 T/C cg02158880 chr13:53174818 NA 0.49 7.19 0.37 4.48e-12 Lewy body disease; CRC cis rs873946 0.586 rs3829130 chr10:134563122 C/T cg27286337 chr10:134555280 INPP5A 0.82 9.94 0.48 1.55e-20 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CRC cis rs11583043 0.918 rs11581062 chr1:101407519 C/T cg00063077 chr1:101360652 SLC30A7;EXTL2 -0.5 -6.97 -0.36 1.7e-11 Ulcerative colitis;Inflammatory bowel disease; CRC cis rs12477438 0.520 rs2516827 chr2:99772565 C/T cg14399236 chr2:99771627 LIPT1;TSGA10 0.82 14.44 0.62 5.96e-37 Chronic sinus infection; CRC cis rs9549367 0.789 rs7999579 chr13:113879357 T/C cg18105134 chr13:113819100 PROZ -0.72 -10.88 -0.51 9.35e-24 Platelet distribution width; CRC cis rs4862750 0.872 rs11947595 chr4:187899827 C/T cg22105103 chr4:187893119 NA 0.64 11.71 0.54 1.01e-26 Lobe attachment (rater-scored or self-reported); CRC cis rs921968 0.565 rs1079177 chr2:219605929 G/A cg02176678 chr2:219576539 TTLL4 -0.39 -6.19 -0.32 1.75e-9 Mean corpuscular hemoglobin concentration; CRC cis rs2243480 1.000 rs35058610 chr7:65390925 G/A cg18252515 chr7:66147081 NA -1.09 -12.75 -0.57 1.6e-30 Diabetic kidney disease; CRC trans rs61931739 0.500 rs7306435 chr12:34482933 A/G cg26384229 chr12:38710491 ALG10B -0.67 -8.87 -0.44 4.81e-17 Morning vs. evening chronotype; CRC cis rs2898681 0.519 rs73814886 chr4:53733251 C/T cg21521518 chr4:53727714 RASL11B 0.41 6.0 0.31 5.26e-9 Optic nerve measurement (cup area); CRC cis rs2463822 0.583 rs72919462 chr11:62035663 G/A cg06239285 chr11:62104954 ASRGL1 -0.77 -7.49 -0.38 6.53e-13 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs4363385 0.818 rs4452994 chr1:152986871 G/A cg25856811 chr1:152973957 SPRR3 -0.24 -6.71 -0.35 8.61e-11 Inflammatory skin disease; CRC cis rs12586317 0.547 rs10142667 chr14:35445090 A/G cg05294307 chr14:35346193 BAZ1A -0.67 -7.21 -0.37 3.89e-12 Psoriasis; CRC cis rs7811142 1.000 rs7787620 chr7:100089234 A/G cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.93 12.29 0.56 8.1e-29 Platelet count; CRC cis rs6912958 0.559 rs373646 chr6:88056896 A/G cg08069147 chr6:88032118 GJB7;C6orf162 0.69 11.27 0.53 3.94e-25 Monocyte percentage of white cells; CRC trans rs12599106 0.560 rs34151874 chr16:34989694 G/A cg26668828 chr6:292823 DUSP22 -0.67 -10.01 -0.48 9.31e-21 Menopause (age at onset); CRC cis rs1552172 0.853 rs10752826 chr1:145602791 C/G cg11743829 chr1:145714124 CD160 0.37 5.85 0.31 1.2e-8 Breast cancer; CRC cis rs6564851 0.545 rs4889285 chr16:81252258 C/T cg00908271 chr16:81254010 PKD1L2 -0.37 -6.07 -0.32 3.5e-9 Carotenoid and tocopherol levels; CRC cis rs863345 0.604 rs12075228 chr1:158502256 C/T cg12129480 chr1:158549410 OR10X1 -0.3 -6.27 -0.33 1.12e-9 Pneumococcal bacteremia; CRC cis rs9733 0.621 rs6669122 chr1:150591732 A/G cg17724175 chr1:150552817 MCL1 -0.51 -8.02 -0.4 1.9e-14 Tonsillectomy; CRC cis rs7916697 0.626 rs3858145 chr10:70011838 A/G cg06988349 chr10:69991859 ATOH7 0.39 7.45 0.38 8.43e-13 Optic disc area; CRC cis rs490234 0.702 rs10120000 chr9:128288428 C/T cg14078157 chr9:128172775 NA -0.4 -6.55 -0.34 2.21e-10 Mean arterial pressure; CRC cis rs7615952 0.611 rs2971298 chr3:125602713 G/A cg05084668 chr3:125655381 ALG1L -0.66 -8.82 -0.44 6.69e-17 Blood pressure (smoking interaction); CRC cis rs672059 1.000 rs672119 chr1:183162506 G/A ch.1.3577855R chr1:183094577 LAMC1 0.49 7.1 0.36 7.63e-12 Hypertriglyceridemia; CRC cis rs896854 0.625 rs4735336 chr8:95973410 A/C cg23172400 chr8:95962367 TP53INP1 0.46 7.79 0.39 8.82e-14 Type 2 diabetes; CRC cis rs2996428 0.667 rs61768932 chr1:3765671 G/C cg17848003 chr1:3704513 LRRC47 0.4 5.81 0.31 1.47e-8 Red cell distribution width; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg02865149 chr11:58939797 DTX4 0.45 6.35 0.33 7.29e-10 Response to antipsychotic treatment; CRC cis rs7317038 0.745 rs75590443 chr13:114015421 A/T cg24344662 chr13:114018021 GRTP1 -0.41 -6.16 -0.32 2.09e-9 Mean platelet volume; CRC cis rs7107174 1.000 rs10899468 chr11:78016650 C/T cg02023728 chr11:77925099 USP35 0.53 7.49 0.38 6.52e-13 Testicular germ cell tumor; CRC cis rs7618501 1.000 rs7648987 chr3:49868455 A/G cg24308560 chr3:49941425 MST1R -0.44 -7.04 -0.36 1.12e-11 Intelligence (multi-trait analysis); CRC cis rs270601 0.661 rs10036208 chr5:131571323 T/C cg01305625 chr5:131593812 PDLIM4 0.34 5.61 0.3 4.38e-8 Acylcarnitine levels; CRC cis rs12745968 0.653 rs1003116 chr1:93166401 C/T cg17283838 chr1:93427260 FAM69A -0.45 -6.1 -0.32 3.04e-9 Bipolar disorder and schizophrenia; CRC cis rs1005277 0.522 rs1208681 chr10:38092975 C/T cg25427524 chr10:38739819 LOC399744 -0.74 -12.75 -0.58 1.59e-30 Extrinsic epigenetic age acceleration; CRC cis rs7937682 1.000 rs11608149 chr11:111535102 G/A cg09085632 chr11:111637200 PPP2R1B 1.04 19.31 0.73 4.64e-56 Primary sclerosing cholangitis; CRC cis rs6952808 0.573 rs12668848 chr7:2020995 G/A cg14004847 chr7:1930337 MAD1L1 -0.43 -6.2 -0.32 1.68e-9 Bipolar disorder and schizophrenia; CRC cis rs6681460 0.932 rs2044400 chr1:67054081 T/A cg02459107 chr1:67143332 SGIP1 0.44 7.45 0.38 8.42e-13 Presence of antiphospholipid antibodies; CRC cis rs9487051 0.872 rs9398197 chr6:109609988 C/A cg01475377 chr6:109611718 NA -0.49 -9.28 -0.46 2.32e-18 Reticulocyte fraction of red cells; CRC cis rs4253772 0.550 rs6007819 chr22:46704916 C/G cg24881330 chr22:46731750 TRMU 0.59 6.35 0.33 7.27e-10 LDL cholesterol;Cholesterol, total; CRC cis rs1707322 0.717 rs3014249 chr1:46079493 A/G cg03146154 chr1:46216737 IPP -0.68 -9.66 -0.47 1.38e-19 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs853679 0.517 rs9368550 chr6:28051803 T/A cg15845792 chr6:28175446 NA 0.97 13.08 0.58 8.89e-32 Depression; CRC cis rs6604026 0.656 rs2811589 chr1:93367643 C/T cg17283838 chr1:93427260 FAM69A -0.43 -5.79 -0.3 1.61e-8 Multiple sclerosis; CRC cis rs6952808 0.723 rs11765550 chr7:2027324 G/A cg22963979 chr7:1858916 MAD1L1 -0.54 -7.85 -0.4 5.83e-14 Bipolar disorder and schizophrenia; CRC trans rs11039798 0.841 rs10839174 chr11:48931185 G/A cg03929089 chr4:120376271 NA 0.64 6.1 0.32 2.95e-9 Axial length; CRC cis rs12971120 1.000 rs2278161 chr18:72176083 T/C cg25817165 chr18:72167213 CNDP2 -0.65 -9.08 -0.45 1.04e-17 Refractive error; CRC cis rs13315871 0.929 rs77487951 chr3:58290892 G/A cg20936604 chr3:58311152 NA -0.72 -6.84 -0.35 3.78e-11 Cholesterol, total; CRC cis rs6424115 0.931 rs11800561 chr1:24164398 T/G cg10978503 chr1:24200527 CNR2 0.47 8.29 0.42 2.94e-15 Immature fraction of reticulocytes; CRC trans rs7618501 0.633 rs2624843 chr3:49997963 G/A cg21659725 chr3:3221576 CRBN 0.53 8.27 0.41 3.38e-15 Intelligence (multi-trait analysis); CRC cis rs17152411 1.000 rs1065301 chr10:126616038 A/G cg07906193 chr10:126599966 NA 0.62 6.83 0.35 4.11e-11 Height; CRC cis rs2243480 0.908 rs2460431 chr7:65622846 A/G cg12463550 chr7:65579703 CRCP -0.71 -6.52 -0.34 2.65e-10 Diabetic kidney disease; CRC cis rs6951245 1.000 rs113146460 chr7:1105164 C/G cg22907277 chr7:1156413 C7orf50 0.74 7.89 0.4 4.63e-14 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs1552244 1.000 rs17032276 chr3:10076975 A/C cg08888203 chr3:10149979 C3orf24 0.73 10.08 0.49 5.45e-21 Alzheimer's disease; CRC cis rs2153535 0.580 rs6910742 chr6:8448328 G/A cg21535247 chr6:8435926 SLC35B3 0.5 7.56 0.38 4.18e-13 Motion sickness; CRC trans rs1005277 0.579 rs11011461 chr10:38431427 G/A cg17830980 chr10:43048298 ZNF37B -0.59 -9.83 -0.48 3.75e-20 Extrinsic epigenetic age acceleration; CRC cis rs4713118 0.869 rs7773070 chr6:27728827 T/C cg25164649 chr6:28176230 NA 0.6 8.51 0.42 6.46e-16 Parkinson's disease; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg08732623 chr10:127408269 C10orf137 0.43 6.6 0.34 1.69e-10 Intelligence (multi-trait analysis); CRC cis rs11212617 1.000 rs228590 chr11:108096141 A/G cg14761454 chr11:108092087 ATM;NPAT 0.43 6.48 0.34 3.39e-10 Response to metformin in type 2 diabetes (glycemic); CRC cis rs4478858 0.806 rs6686845 chr1:31708796 A/T cg18939081 chr1:31884902 SERINC2 0.35 5.7 0.3 2.72e-8 Alcohol dependence; CRC cis rs644799 0.710 rs10831427 chr11:95508383 G/T cg03916912 chr11:95522834 CEP57;FAM76B 0.86 15.76 0.66 4.41e-42 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs2075371 1.000 rs2598296 chr7:133992985 C/T cg11752832 chr7:134001865 SLC35B4 0.5 7.62 0.39 2.7e-13 Mean platelet volume; CRC cis rs4132509 0.739 rs10927033 chr1:243695539 C/A cg21452805 chr1:244014465 NA 0.54 5.64 0.3 3.61e-8 RR interval (heart rate); CRC cis rs77861329 1.000 rs9816434 chr3:52197513 C/T cg08692210 chr3:52188851 WDR51A 0.87 8.1 0.41 1.12e-14 Macrophage inflammatory protein 1b levels; CRC cis rs7727544 0.735 rs272842 chr5:131656517 A/G cg07395648 chr5:131743802 NA -0.39 -6.06 -0.32 3.8e-9 Blood metabolite levels; CRC cis rs1552244 0.935 rs41520445 chr3:10153141 A/C cg02579736 chr3:10068473 FANCD2;CIDECP -1.02 -13.34 -0.59 9.74e-33 Alzheimer's disease; CRC cis rs7772486 0.790 rs6917135 chr6:146152426 T/C cg23711669 chr6:146136114 FBXO30 0.67 11.47 0.53 7.77e-26 Lobe attachment (rater-scored or self-reported); CRC cis rs35146811 0.700 rs858513 chr7:99825558 G/A cg00553149 chr7:99775558 STAG3;GPC2 -0.25 -5.74 -0.3 2.16e-8 Coronary artery disease; CRC cis rs13064411 0.696 rs13325046 chr3:113104444 C/T cg10517650 chr3:113235015 CCDC52 -0.4 -6.27 -0.33 1.13e-9 Response to simvastatin treatment (PCSK9 protein level change); CRC cis rs9926296 0.607 rs11076629 chr16:89875259 T/C cg04287289 chr16:89883240 FANCA 0.6 9.68 0.47 1.17e-19 Vitiligo; CRC cis rs6461049 0.765 rs1476887 chr7:2151633 T/C cg22963979 chr7:1858916 MAD1L1 -0.38 -5.7 -0.3 2.62e-8 Schizophrenia; CRC trans rs208520 0.633 rs7738469 chr6:66807446 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.07 -15.17 -0.64 8.62e-40 Exhaled nitric oxide output; CRC cis rs637571 0.510 rs12575663 chr11:65574535 G/A cg26695010 chr11:65641043 EFEMP2 0.48 7.46 0.38 7.59e-13 Eosinophil percentage of white cells; CRC cis rs10504229 0.683 rs35840293 chr8:58117634 C/T cg04204079 chr8:58130323 NA -0.45 -5.78 -0.3 1.71e-8 Developmental language disorder (linguistic errors); CRC cis rs60311166 1.000 rs7643568 chr3:52578474 A/G cg13174197 chr3:52720522 GNL3;PBRM1 0.85 6.59 0.34 1.79e-10 CTACK levels; CRC cis rs4555082 0.834 rs2735826 chr14:105710866 G/A cg06808227 chr14:105710500 BRF1 -0.62 -9.09 -0.45 9.84e-18 Mean platelet volume;Platelet distribution width; CRC cis rs12760731 0.641 rs12036834 chr1:178236583 G/A cg00404053 chr1:178313656 RASAL2 0.96 10.07 0.49 5.59e-21 Obesity-related traits; CRC cis rs7538876 1.000 rs942457 chr1:17739586 G/A cg07965774 chr1:17746286 RCC2 0.31 5.92 0.31 7.9e-9 Basal cell carcinoma; CRC cis rs2243480 1.000 rs56291018 chr7:65390339 G/A cg12463550 chr7:65579703 CRCP 0.67 6.41 0.33 5.16e-10 Diabetic kidney disease; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg03448396 chr3:38495949 LOC100128640;ACVR2B 0.44 6.83 0.35 4.18e-11 Intelligence (multi-trait analysis); CRC cis rs514406 0.505 rs374849 chr1:53185631 G/A cg08859206 chr1:53392774 SCP2 -0.4 -6.13 -0.32 2.45e-9 Monocyte count; CRC cis rs8067545 0.611 rs2526476 chr17:20134289 C/T cg13482628 chr17:19912719 NA -0.46 -7.27 -0.37 2.62e-12 Schizophrenia; CRC trans rs6550704 0.687 rs9865314 chr3:22634337 A/G cg00295835 chr11:113644563 ZW10 -0.41 -5.98 -0.31 5.66e-9 Daytime sleep phenotypes; CRC cis rs853679 0.517 rs1853097 chr6:28058635 A/G cg12172441 chr6:28176163 NA 0.62 7.38 0.38 1.28e-12 Depression; CRC trans rs12478296 0.786 rs6721704 chr2:242994923 A/G cg06834434 chr14:75079333 LTBP2 0.57 6.88 0.35 3.1e-11 Obesity-related traits; CRC cis rs1997103 1.000 rs6973450 chr7:55396537 A/G cg17469321 chr7:55412551 NA 0.74 11.38 0.53 1.54e-25 QRS interval (sulfonylurea treatment interaction); CRC cis rs769267 0.965 rs2074299 chr19:19380646 T/C cg20644253 chr19:19431407 KIAA0892;SF4 0.43 6.02 0.31 4.71e-9 Tonsillectomy; CRC cis rs9818941 0.824 rs13065628 chr3:157789277 A/G cg08654915 chr3:157813417 NA -0.3 -5.64 -0.3 3.7e-8 Height; CRC cis rs904251 0.734 rs2797790 chr6:37447075 A/G cg25019722 chr6:37503610 NA 0.36 5.89 0.31 9.3e-9 Cognitive performance; CRC cis rs2235649 0.833 rs4335769 chr16:1849376 G/A cg00935504 chr16:1863053 HAGH 0.31 5.65 0.3 3.39e-8 Blood metabolite levels; CRC cis rs4604732 0.588 rs4925552 chr1:247631749 C/A cg02104434 chr1:247694406 LOC148824;OR2C3 0.5 7.7 0.39 1.64e-13 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CRC cis rs57590327 0.555 rs11127740 chr3:81743062 A/C cg07356753 chr3:81810745 GBE1 -0.63 -8.62 -0.43 2.86e-16 Extraversion; CRC cis rs17065868 0.764 rs9533849 chr13:45011384 T/C cg10246903 chr13:45222710 NA 0.56 6.21 0.32 1.64e-9 Antineutrophil cytoplasmic antibody-associated vasculitis; CRC cis rs910316 1.000 rs7303 chr14:75520065 T/C cg11812906 chr14:75593930 NEK9 0.63 9.96 0.48 1.38e-20 Height; CRC cis rs7249142 0.549 rs10854012 chr19:19295719 C/T cg12558012 chr19:19281197 LOC729991-MEF2B;MEF2B 0.58 9.12 0.45 7.71e-18 IgG glycosylation; CRC cis rs7762018 1.000 rs7762018 chr6:170113244 G/T cg17545662 chr6:170176663 C6orf70 0.49 5.86 0.31 1.15e-8 Thiazide-induced adverse metabolic effects in hypertensive patients; CRC cis rs9430161 0.579 rs11121669 chr1:11039567 T/C cg27631724 chr1:11040367 C1orf127 0.33 6.62 0.34 1.45e-10 Ewing sarcoma; CRC cis rs2549003 0.811 rs10072700 chr5:131816903 A/C cg21138405 chr5:131827807 IRF1 0.52 8.17 0.41 6.89e-15 Asthma (sex interaction); CRC cis rs172166 0.652 rs476167 chr6:28065888 T/C cg26587870 chr6:27730563 NA -0.37 -5.64 -0.3 3.62e-8 Cardiac Troponin-T levels; CRC cis rs951366 0.764 rs708724 chr1:205743663 A/C cg14893161 chr1:205819251 PM20D1 0.83 13.48 0.6 2.7e-33 Menarche (age at onset); CRC cis rs853679 0.517 rs56364346 chr6:28050762 T/G cg06470822 chr6:28175283 NA 0.98 13.22 0.59 2.69e-32 Depression; CRC cis rs10504229 0.610 rs7840469 chr8:58146992 C/T cg02725872 chr8:58115012 NA -0.59 -11.2 -0.53 7.13e-25 Developmental language disorder (linguistic errors); CRC cis rs425277 0.606 rs12082939 chr1:2078922 C/T cg24578937 chr1:2090814 PRKCZ 0.37 6.9 0.36 2.65e-11 Height; CRC cis rs9916302 0.904 rs4511574 chr17:37532916 A/G cg07936489 chr17:37558343 FBXL20 -0.82 -13.14 -0.59 5.39e-32 Glomerular filtration rate (creatinine); CRC cis rs1401999 0.966 rs2139560 chr3:183653869 A/G cg20387954 chr3:183756860 HTR3D 0.46 7.81 0.4 7.86e-14 Anterior chamber depth; CRC cis rs728616 0.867 rs12415870 chr10:81949470 A/G cg11900509 chr10:81946545 ANXA11 -0.71 -7.16 -0.37 5.2e-12 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs9372498 0.505 rs9489493 chr6:118992323 T/C cg24463073 chr6:118973353 C6orf204 0.44 6.14 0.32 2.44e-9 Diastolic blood pressure; CRC cis rs7193541 0.640 rs4072222 chr16:74706736 A/C cg01733217 chr16:74700730 RFWD3 1.02 21.3 0.76 7.18e-64 Multiple myeloma; CRC cis rs11677370 0.574 rs10190477 chr2:3862738 A/G cg17052675 chr2:3827356 NA 0.64 10.82 0.51 1.47e-23 Type 2 diabetes; CRC cis rs4481887 0.676 rs1544177 chr1:248524683 C/G cg00666640 chr1:248458726 OR2T12 0.35 6.56 0.34 2.15e-10 Common traits (Other); CRC cis rs7193541 0.684 rs8062783 chr16:74691264 C/T cg01733217 chr16:74700730 RFWD3 -1.03 -20.99 -0.76 1.12e-62 Multiple myeloma; CRC cis rs2455601 0.882 rs11042105 chr11:8894510 G/C cg09997546 chr11:8931473 C11orf17;ST5 -0.52 -6.85 -0.35 3.62e-11 Schizophrenia; CRC cis rs35306767 0.903 rs11253493 chr10:936931 T/C cg20503657 chr10:835505 NA 0.95 11.73 0.54 8.69e-27 Eosinophil percentage of granulocytes; CRC cis rs7618915 0.570 rs11130312 chr3:52675055 A/C cg15147215 chr3:52552868 STAB1 -0.62 -10.24 -0.49 1.48e-21 Bipolar disorder; CRC cis rs501120 0.584 rs11595159 chr10:44680608 T/C cg09554077 chr10:44749378 NA 0.7 7.85 0.4 5.95e-14 Coronary artery disease;Coronary heart disease; CRC cis rs11608355 0.576 rs1477117 chr12:109888779 A/G cg05360138 chr12:110035743 NA -0.65 -6.87 -0.35 3.27e-11 Neuroticism; CRC cis rs694739 0.541 rs61886926 chr11:64133552 C/T cg02228329 chr11:64053129 BAD;GPR137 0.49 6.68 0.35 1.04e-10 Alopecia areata;Crohn's disease;Psoriasis vulgaris; CRC cis rs7666738 0.830 rs28818218 chr4:98880575 A/C cg17366294 chr4:99064904 C4orf37 0.43 7.1 0.36 7.83e-12 Colonoscopy-negative controls vs population controls; CRC cis rs13108904 0.539 rs13135102 chr4:1330983 A/C cg20092199 chr4:1342459 KIAA1530 0.45 7.23 0.37 3.5e-12 Obesity-related traits; CRC cis rs12188164 0.686 rs72711370 chr5:421057 A/C cg17553881 chr5:443987 EXOC3;C5orf55 -0.37 -7.52 -0.38 5.35e-13 Cystic fibrosis severity; CRC cis rs34375054 0.526 rs7302475 chr12:125677886 T/C cg06287003 chr12:125626642 AACS -0.51 -7.07 -0.36 9.34e-12 Post bronchodilator FEV1/FVC ratio; CRC cis rs6163 0.588 rs3818708 chr10:104503584 C/T cg04362960 chr10:104952993 NT5C2 0.46 6.83 0.35 4.12e-11 Waist circumference;Hip circumference; CRC cis rs6089584 0.528 rs881994 chr20:60623931 G/A cg23262073 chr20:60523788 NA -0.42 -6.65 -0.34 1.21e-10 Body mass index; CRC cis rs2153535 0.580 rs6912193 chr6:8456306 T/G cg21535247 chr6:8435926 SLC35B3 0.5 7.5 0.38 5.81e-13 Motion sickness; CRC cis rs7487075 0.820 rs2408505 chr12:46717824 C/A cg22049899 chr12:47219821 SLC38A4 0.34 6.58 0.34 1.83e-10 Itch intensity from mosquito bite; CRC trans rs10435719 0.902 rs7006538 chr8:11804982 A/G cg08975724 chr8:8085496 FLJ10661 0.42 6.43 0.33 4.5e-10 C-reactive protein levels or triglyceride levels (pleiotropy); CRC cis rs60843830 0.661 rs62116682 chr2:104618 C/T cg25945732 chr2:264204 ACP1;SH3YL1 0.46 6.39 0.33 5.56e-10 Spherical equivalent (joint analysis main effects and education interaction); CRC cis rs3823572 0.564 rs2971955 chr7:133665939 C/T cg03336402 chr7:133662267 EXOC4 0.59 9.47 0.46 5.5e-19 Intelligence (multi-trait analysis); CRC cis rs12024301 0.557 rs12073256 chr1:183658377 T/A cg11505048 chr1:183622726 RGL1;APOBEC4 0.71 6.24 0.33 1.33e-9 Peripheral arterial disease (traffic-related air pollution interaction); CRC trans rs11039798 0.925 rs10769373 chr11:48531980 T/A cg15704280 chr7:45808275 SEPT13 0.63 6.04 0.32 4.23e-9 Axial length; CRC cis rs1971762 0.563 rs4759284 chr12:54079491 G/A cg06632207 chr12:54070931 ATP5G2 0.41 7.09 0.36 8.23e-12 Height; CRC cis rs3812565 0.530 rs10781538 chr9:139320929 C/G cg14019695 chr9:139328340 INPP5E -0.43 -6.57 -0.34 1.95e-10 Granulocyte percentage of myeloid white cells; CRC cis rs1008375 0.966 rs28750296 chr4:17685826 A/T cg04450456 chr4:17643702 FAM184B 0.39 6.35 0.33 7.32e-10 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs2721195 0.967 rs748193 chr8:145682115 C/T cg15857475 chr8:145742913 RECQL4;LRRC14 0.68 11.12 0.52 1.32e-24 Age at first birth; CRC cis rs7945718 0.621 rs10831894 chr11:12680733 G/A cg25843174 chr11:12811716 TEAD1 0.4 7.43 0.38 9.67e-13 Educational attainment (years of education); CRC cis rs8180040 0.726 rs4682844 chr3:46982737 T/C cg02527881 chr3:46936655 PTH1R 0.42 7.54 0.38 4.75e-13 Colorectal cancer; CRC cis rs34172651 0.517 rs2303084 chr16:24834581 G/C cg06505273 chr16:24850292 NA 0.51 6.19 0.32 1.77e-9 Intelligence (multi-trait analysis); CRC trans rs7395662 0.591 rs10838972 chr11:48611400 A/G cg21153622 chr11:89784906 NA -0.52 -8.68 -0.43 1.92e-16 HDL cholesterol; CRC cis rs11212617 1.000 rs11212610 chr11:108274593 T/C cg12106634 chr11:108092400 ATM;NPAT 0.4 5.83 0.31 1.29e-8 Response to metformin in type 2 diabetes (glycemic); CRC cis rs1865760 0.663 rs9348704 chr6:26000393 A/C cg18357526 chr6:26021779 HIST1H4A 0.41 6.0 0.31 5.31e-9 Height; CRC cis rs9287719 0.837 rs4233883 chr2:10755596 A/G cg00105475 chr2:10696890 NA 0.46 7.25 0.37 3.08e-12 Prostate cancer; CRC cis rs34375054 0.525 rs7133006 chr12:125606123 G/A cg06287003 chr12:125626642 AACS -0.5 -7.5 -0.38 6.18e-13 Post bronchodilator FEV1/FVC ratio; CRC cis rs1832871 0.672 rs9457361 chr6:158771750 G/A cg07165851 chr6:158734300 TULP4 0.62 7.81 0.4 7.61e-14 Height; CRC cis rs1580019 0.587 rs6972365 chr7:32548931 T/A cg07520158 chr7:32535189 LSM5;AVL9 0.55 8.08 0.41 1.25e-14 Cognitive ability; CRC cis rs2806561 0.514 rs11801120 chr1:23543307 C/T cg19743168 chr1:23544995 NA 0.58 8.44 0.42 9.92e-16 Height; CRC trans rs10982213 0.830 rs2274163 chr9:117188714 C/T cg12074093 chr17:16256568 CENPV 0.41 6.57 0.34 1.92e-10 Interleukin-6 levels; CRC cis rs6951245 0.786 rs77943789 chr7:1140158 C/T cg26224354 chr7:1096374 C7orf50;GPR146 -0.85 -11.36 -0.53 1.85e-25 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg08934607 chr11:20409647 PRMT3 0.47 6.08 0.32 3.35e-9 Thyroid stimulating hormone; CRC cis rs8180040 0.701 rs13066214 chr3:47033937 C/T cg02527881 chr3:46936655 PTH1R -0.39 -7.31 -0.37 2.09e-12 Colorectal cancer; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg01794711 chr18:72163198 CNDP2 0.41 6.01 0.31 4.9e-9 Intelligence (multi-trait analysis); CRC cis rs13217239 0.646 rs6937880 chr6:27000236 C/T cg05192639 chr6:26864778 GUSBL1 0.31 6.05 0.32 4.01e-9 Schizophrenia; CRC cis rs6831352 0.918 rs17817359 chr4:100054197 G/T cg12011299 chr4:100065546 ADH4 -0.49 -9.27 -0.45 2.61e-18 Alcohol dependence; CRC cis rs11690935 0.851 rs9808259 chr2:172648974 C/T cg13550731 chr2:172543902 DYNC1I2 -1.07 -18.55 -0.71 4.64e-53 Schizophrenia; CRC cis rs1055129 0.560 rs9891076 chr17:73911715 C/T cg08125733 chr17:73851984 WBP2 0.47 6.13 0.32 2.49e-9 White matter hyperintensity burden; CRC cis rs11105298 0.891 rs4842662 chr12:89933446 T/C cg08166232 chr12:89918718 WDR51B;GALNT4 -0.59 -7.31 -0.37 2.08e-12 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; CRC cis rs12900413 0.687 rs34284515 chr15:90308061 T/G cg24249390 chr15:90295951 MESP1 -0.57 -9.13 -0.45 7.11e-18 Coronary artery aneurysm in Kawasaki disease; CRC cis rs17666538 1.000 rs61064968 chr8:587933 T/C cg02524346 chr8:600233 NA -0.93 -8.26 -0.41 3.66e-15 IgG glycosylation; CRC trans rs10983614 1.000 rs7867776 chr9:120072627 A/G ch.9.86947500F chr9:87757680 NA 0.45 6.22 0.32 1.49e-9 Survival in pancreatic cancer; CRC trans rs1814175 0.645 rs11040702 chr11:50024827 C/T cg11707556 chr5:10655725 ANKRD33B -0.52 -10.25 -0.49 1.36e-21 Height; CRC cis rs10540 1.000 rs79808876 chr11:465763 C/A cg15790184 chr11:494944 RNH1 0.59 6.07 0.32 3.55e-9 Body mass index; CRC cis rs992157 1.000 rs6736362 chr2:219115108 C/T cg00012203 chr2:219082015 ARPC2 0.55 8.67 0.43 2.04e-16 Colorectal cancer; CRC cis rs977987 0.806 rs4993970 chr16:75411619 G/A cg03315344 chr16:75512273 CHST6 0.53 8.85 0.44 5.48e-17 Dupuytren's disease; CRC cis rs270601 0.683 rs81598 chr5:131587960 C/G cg18301423 chr5:131593218 PDLIM4 0.45 7.62 0.39 2.8e-13 Acylcarnitine levels; CRC cis rs853679 0.546 rs200996 chr6:27811828 G/A cg26587870 chr6:27730563 NA -0.66 -6.84 -0.35 3.89e-11 Depression; CRC cis rs2012796 0.743 rs61986598 chr14:81856865 G/A cg02996355 chr14:81879375 NA 0.62 9.34 0.46 1.5e-18 Night sleep phenotypes; CRC trans rs1864585 0.505 rs73208792 chr8:10680471 C/T cg26278703 chr11:58910052 FAM111A 0.56 6.55 0.34 2.24e-10 Neutrophil percentage of white cells;Lymphocyte percentage of white cells; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg19877921 chr17:61904685 PSMC5;FTSJ3 0.42 6.67 0.35 1.09e-10 Liver disease severity in Alagille syndrome; CRC cis rs6461049 0.800 rs1860831 chr7:2160931 T/C cg04267008 chr7:1944627 MAD1L1 -0.5 -6.98 -0.36 1.6e-11 Schizophrenia; CRC cis rs1538970 0.781 rs11211139 chr1:46015751 G/T cg05343316 chr1:45956843 TESK2 0.73 9.4 0.46 9.91e-19 Platelet count; CRC cis rs801193 1.000 rs11773829 chr7:66141074 G/A cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.43 -6.24 -0.33 1.31e-9 Aortic root size; CRC cis rs4862750 0.914 rs11945845 chr4:187874136 T/C cg06074448 chr4:187884817 NA -0.58 -10.74 -0.51 2.79e-23 Lobe attachment (rater-scored or self-reported); CRC cis rs7542091 0.748 rs2357231 chr1:210028454 A/C cg09163369 chr1:210001066 C1orf107 0.39 5.86 0.31 1.15e-8 Monobrow; CRC trans rs7267979 1.000 rs2482937 chr20:25340786 A/G cg17903999 chr18:56338584 MALT1 0.43 7.01 0.36 1.39e-11 Liver enzyme levels (alkaline phosphatase); CRC trans rs7267979 1.000 rs2258135 chr20:25272323 C/A cg17903999 chr18:56338584 MALT1 -0.41 -6.92 -0.36 2.32e-11 Liver enzyme levels (alkaline phosphatase); CRC cis rs2153535 0.542 rs6912740 chr6:8439959 A/G cg07606381 chr6:8435919 SLC35B3 0.68 10.86 0.51 1.08e-23 Motion sickness; CRC cis rs1862618 0.853 rs832551 chr5:56180112 T/G cg24531977 chr5:56204891 C5orf35 -0.84 -10.92 -0.52 6.54e-24 Initial pursuit acceleration; CRC cis rs9487051 0.898 rs882072 chr6:109611806 A/G cg12927641 chr6:109611667 NA -0.38 -6.87 -0.35 3.28e-11 Reticulocyte fraction of red cells; CRC cis rs28386778 0.897 rs4638645 chr17:61828349 T/C cg23090583 chr17:61904693 PSMC5;FTSJ3 1.05 20.23 0.74 1.07e-59 Prudent dietary pattern; CRC cis rs875971 0.862 rs13226170 chr7:65999298 G/A cg00343986 chr7:65444356 GUSB 0.44 6.16 0.32 2.15e-9 Aortic root size; CRC cis rs7072216 0.770 rs3830020 chr10:100176615 C/G cg26618903 chr10:100175079 PYROXD2 0.4 6.66 0.34 1.15e-10 Metabolite levels; CRC cis rs773506 0.628 rs10733740 chr9:93933158 G/T cg14446406 chr9:93919335 NA 0.43 7.27 0.37 2.58e-12 Type 2 diabetes nephropathy; CRC trans rs475616 0.917 rs866919 chr10:30513283 C/T ch.2.3330114R chr2:163935707 NA 0.43 6.05 0.32 4.02e-9 Monocyte count; CRC cis rs4819052 0.918 rs2330013 chr21:46658662 G/T cg11663144 chr21:46675770 NA -0.79 -11.43 -0.53 1.05e-25 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs73206853 0.764 rs970228 chr12:111070169 G/C cg12870014 chr12:110450643 ANKRD13A 0.81 9.34 0.46 1.45e-18 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC cis rs7587476 0.906 rs3768713 chr2:215637505 G/A cg04004882 chr2:215674386 BARD1 0.59 7.28 0.37 2.53e-12 Neuroblastoma; CRC cis rs7811142 1.000 rs11771419 chr7:99988403 A/G cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.13 16.55 0.67 3.45e-45 Platelet count; CRC cis rs17209837 1.000 rs45546132 chr7:87086140 C/T cg00919237 chr7:87102261 ABCB4 -0.5 -6.1 -0.32 3.03e-9 Gallbladder cancer; CRC cis rs7666738 0.753 rs28390295 chr4:99028497 C/A cg05340658 chr4:99064831 C4orf37 0.61 9.42 0.46 8.23e-19 Colonoscopy-negative controls vs population controls; CRC cis rs9649465 0.522 rs662705 chr7:123431594 A/C cg03229431 chr7:123269106 ASB15 0.51 8.15 0.41 7.53e-15 Migraine; CRC cis rs780096 0.546 rs2293572 chr2:27728777 C/G cg24768116 chr2:27665128 KRTCAP3 0.33 7.32 0.37 1.95e-12 Total body bone mineral density; CRC cis rs758324 0.812 rs667419 chr5:131282064 A/G cg25547332 chr5:131281432 NA 0.36 5.74 0.3 2.17e-8 Alzheimer's disease in APOE e4- carriers; CRC cis rs28386778 0.897 rs8067102 chr17:61848779 C/G cg23090583 chr17:61904693 PSMC5;FTSJ3 1.05 20.23 0.74 1.07e-59 Prudent dietary pattern; CRC cis rs3772130 0.564 rs4420917 chr3:121567863 T/C cg20356878 chr3:121714668 ILDR1 0.37 6.08 0.32 3.24e-9 Cognitive performance; CRC cis rs12760731 0.668 rs12073428 chr1:178427933 G/A cg00404053 chr1:178313656 RASAL2 0.73 8.43 0.42 1.07e-15 Obesity-related traits; CRC cis rs853679 0.517 rs9348796 chr6:28126202 A/G cg21251018 chr6:28226885 NKAPL 0.48 6.17 0.32 2.02e-9 Depression; CRC cis rs4148883 0.675 rs11724783 chr4:100099688 C/A cg12011299 chr4:100065546 ADH4 0.5 10.97 0.52 4.61e-24 Alcohol dependence; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg23128382 chr11:59382818 OSBP 0.45 6.28 0.33 1.09e-9 Response to antipsychotic treatment; CRC cis rs174479 0.647 rs174457 chr11:61656975 T/C cg01500311 chr11:61656094 FADS3 0.35 5.69 0.3 2.76e-8 Sphingolipid levels; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg19926395 chr7:150865207 GBX1 0.33 6.5 0.34 2.97e-10 Liver disease severity in Alagille syndrome; CRC cis rs2832191 0.692 rs2245734 chr21:30359965 C/T cg08807101 chr21:30365312 RNF160 0.72 11.44 0.53 1e-25 Dental caries; CRC cis rs763121 0.886 rs1013339 chr22:38974680 C/T cg06022373 chr22:39101656 GTPBP1 0.74 12.19 0.56 1.8e-28 Menopause (age at onset); CRC cis rs4363385 0.693 rs76987906 chr1:152964530 A/G cg25856811 chr1:152973957 SPRR3 -0.26 -7.05 -0.36 1.05e-11 Inflammatory skin disease; CRC cis rs11168351 0.833 rs6580652 chr12:48447105 C/A cg21466736 chr12:48725269 NA 0.46 7.04 0.36 1.12e-11 Bipolar disorder and schizophrenia; CRC cis rs372883 0.600 rs1153276 chr21:30661694 T/C cg08807101 chr21:30365312 RNF160 -0.58 -8.1 -0.41 1.09e-14 Pancreatic cancer; CRC cis rs7615952 0.512 rs4646765 chr3:125820707 G/A cg06494592 chr3:125709126 NA -0.57 -6.78 -0.35 5.71e-11 Blood pressure (smoking interaction); CRC cis rs3806843 0.576 rs246020 chr5:140334771 G/A cg19875535 chr5:140030758 IK 0.4 6.12 0.32 2.64e-9 Depressive symptoms (multi-trait analysis); CRC cis rs7737355 0.773 rs184949 chr5:130815593 A/G cg25547332 chr5:131281432 NA -0.35 -5.69 -0.3 2.74e-8 Life satisfaction; CRC cis rs9287719 0.934 rs6432111 chr2:10744620 A/C cg00105475 chr2:10696890 NA 0.45 7.3 0.37 2.2e-12 Prostate cancer; CRC cis rs763014 0.966 rs12935215 chr16:670605 T/C cg08989290 chr16:615782 NHLRC4 0.48 9.3 0.46 1.96e-18 Height; CRC cis rs10791097 0.678 rs10894272 chr11:130731081 A/G cg12179176 chr11:130786555 SNX19 0.64 10.5 0.5 1.95e-22 Autism spectrum disorder or schizophrenia;Schizophrenia; CRC cis rs45509595 0.659 rs390764 chr6:27782535 C/T cg03623178 chr6:28175578 NA 0.78 6.64 0.34 1.27e-10 Breast cancer; CRC cis rs9487051 0.933 rs5005289 chr6:109617673 C/G cg01475377 chr6:109611718 NA -0.44 -7.89 -0.4 4.61e-14 Reticulocyte fraction of red cells; CRC cis rs7937682 0.883 rs549143 chr11:111463779 C/T cg19812747 chr11:111475976 SIK2 -0.57 -9.72 -0.47 8.51e-20 Primary sclerosing cholangitis; CRC cis rs838147 0.537 rs602662 chr19:49206985 G/A cg21064579 chr19:49206444 FUT2 0.49 8.48 0.42 7.99e-16 Dietary macronutrient intake; CRC cis rs9826463 0.702 rs73228757 chr3:142320081 A/G cg20824294 chr3:142316082 PLS1 0.42 6.69 0.35 9.5e-11 QRS duration in Tripanosoma cruzi seropositivity; CRC cis rs2836974 0.965 rs7354783 chr21:40652992 G/A cg11890956 chr21:40555474 PSMG1 1.11 19.05 0.72 4.69e-55 Cognitive function; CRC cis rs8077889 0.917 rs58283314 chr17:41905963 T/G cg16892393 chr17:41919603 NA 0.49 7.55 0.38 4.32e-13 Triglycerides; CRC trans rs12702919 0.677 rs12702917 chr7:9550478 G/A cg15597424 chr4:24472487 NA -0.39 -5.99 -0.31 5.47e-9 PR interval in Tripanosoma cruzi seropositivity; CRC cis rs7772486 0.790 rs9497425 chr6:146234197 G/A cg23711669 chr6:146136114 FBXO30 -0.66 -11.27 -0.53 3.91e-25 Lobe attachment (rater-scored or self-reported); CRC cis rs6860806 0.695 rs11952099 chr5:131576772 A/G cg27615366 chr5:131592974 PDLIM4 0.29 5.64 0.3 3.68e-8 Breast cancer; CRC cis rs7617773 0.780 rs11718350 chr3:48360992 T/G cg11946769 chr3:48343235 NME6 0.76 10.12 0.49 3.87e-21 Coronary artery disease; CRC cis rs7666738 0.752 rs35436270 chr4:99088280 G/A cg05340658 chr4:99064831 C4orf37 0.51 6.41 0.33 5.02e-10 Colonoscopy-negative controls vs population controls; CRC cis rs7591163 0.959 rs2396497 chr2:228724139 T/C cg22079747 chr2:228736145 WDR69 -0.41 -5.65 -0.3 3.4e-8 Blood pressure; CRC cis rs6952808 0.692 rs12666575 chr7:2004421 C/T cg20295408 chr7:1910781 MAD1L1 -0.43 -5.91 -0.31 8.4e-9 Bipolar disorder and schizophrenia; CRC cis rs367943 0.966 rs348947 chr5:112822795 C/G cg12552261 chr5:112820674 MCC -0.49 -7.52 -0.38 5.23e-13 Type 2 diabetes; CRC cis rs524281 0.861 rs9736673 chr11:65924024 T/A cg16950941 chr11:66035639 RAB1B -0.59 -7.65 -0.39 2.28e-13 Electroencephalogram traits; CRC cis rs7605827 0.930 rs6728145 chr2:15573489 C/G cg19274914 chr2:15703543 NA 0.39 5.99 0.31 5.53e-9 Educational attainment (years of education); CRC trans rs11088226 1.000 rs2833888 chr21:33927560 A/G cg09050820 chr6:167586206 TCP10L2 0.57 6.44 0.33 4.32e-10 Gastritis; CRC cis rs9814567 1.000 rs9289471 chr3:134230811 A/G cg06541857 chr3:134203789 ANAPC13;CEP63 -0.41 -6.19 -0.32 1.74e-9 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs4665809 1.000 rs6729757 chr2:26285102 A/G cg22920501 chr2:26401640 FAM59B -0.53 -7.23 -0.37 3.39e-12 Gut microbiome composition (summer); CRC cis rs6938 0.618 rs11857695 chr15:75165751 G/T cg09165964 chr15:75287851 SCAMP5 0.55 8.78 0.44 9.3e-17 Breast cancer; CRC cis rs2304069 0.545 rs12153714 chr5:149395254 A/G cg22760475 chr5:149380129 HMGXB3;TIGD6 0.45 6.6 0.34 1.62e-10 HIV-1 control; CRC cis rs2797160 1.000 rs1630556 chr6:126013155 A/G cg05901451 chr6:126070800 HEY2 0.4 6.12 0.32 2.71e-9 Endometrial cancer; CRC cis rs10504229 0.511 rs75967910 chr8:58024231 C/G cg08219700 chr8:58056026 NA 0.56 6.58 0.34 1.81e-10 Developmental language disorder (linguistic errors); CRC cis rs9488822 0.676 rs10456902 chr6:116333742 C/G cg05304507 chr6:116381966 FRK -0.29 -7.8 -0.4 8.18e-14 Cholesterol, total;LDL cholesterol; CRC cis rs6951245 0.935 rs112554101 chr7:1065535 A/G cg07217954 chr7:1067459 C7orf50 0.51 6.03 0.32 4.33e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs6088580 0.634 rs6120650 chr20:33039973 G/A cg24642439 chr20:33292090 TP53INP2 0.36 6.17 0.32 2.06e-9 Glomerular filtration rate (creatinine); CRC cis rs629535 0.814 rs72654071 chr8:70079484 A/G cg26132723 chr8:70041827 NA -0.35 -5.63 -0.3 3.87e-8 Dupuytren's disease; CRC cis rs7659604 0.540 rs11734075 chr4:122695685 C/T cg19748678 chr4:122722346 EXOSC9 -0.44 -6.02 -0.31 4.78e-9 Type 2 diabetes; CRC cis rs3087591 0.683 rs2854306 chr17:29648146 G/A cg24425628 chr17:29625626 OMG;NF1 0.71 13.15 0.59 4.98e-32 Hip circumference; CRC cis rs769267 0.930 rs4808955 chr19:19552413 T/C cg17414380 chr19:19431394 KIAA0892;SF4 0.43 5.66 0.3 3.3e-8 Tonsillectomy; CRC cis rs7493 1.000 rs2299265 chr7:95048870 C/G cg17330251 chr7:94953956 PON1 -0.59 -7.5 -0.38 5.82e-13 Yu-Zhi constitution type in type 2 diabetes; CRC trans rs9388451 0.807 rs1269175 chr6:126040435 A/G cg05039488 chr6:79577232 IRAK1BP1 0.56 8.57 0.43 4.16e-16 Brugada syndrome; CRC cis rs3768617 0.510 rs10797837 chr1:183075121 C/G ch.1.3577855R chr1:183094577 LAMC1 0.87 15.46 0.65 6.33e-41 Fuchs's corneal dystrophy; CRC cis rs1957429 0.901 rs7143661 chr14:65378981 G/A cg23373153 chr14:65346875 NA 0.81 8.5 0.42 6.81e-16 Pediatric areal bone mineral density (radius); CRC cis rs644799 0.544 rs1150360 chr11:95512060 A/G cg03916912 chr11:95522834 CEP57;FAM76B 0.7 11.6 0.54 2.61e-26 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs4594175 0.926 rs7493621 chr14:51623665 C/T cg23942311 chr14:51606299 NA 0.6 9.53 0.46 3.71e-19 Cancer; CRC trans rs2797160 1.000 rs2747724 chr6:126004935 G/A cg05039488 chr6:79577232 IRAK1BP1 -0.49 -7.32 -0.37 1.91e-12 Endometrial cancer; CRC cis rs9916302 0.555 rs12940193 chr17:37652178 T/G cg00129232 chr17:37814104 STARD3 -0.55 -8.13 -0.41 8.96e-15 Glomerular filtration rate (creatinine); CRC cis rs2180341 0.640 rs11154395 chr6:127629138 T/C cg24812749 chr6:127587940 RNF146 0.64 9.58 0.47 2.48e-19 Breast cancer; CRC cis rs10499694 0.933 rs12538938 chr7:50592313 A/G cg18232548 chr7:50535776 DDC -0.41 -6.18 -0.32 1.93e-9 Body mass index; CRC cis rs7945718 0.621 rs10831888 chr11:12665604 T/C cg25843174 chr11:12811716 TEAD1 0.37 6.87 0.35 3.28e-11 Educational attainment (years of education); CRC cis rs11948739 0.539 rs10045319 chr5:130250710 G/A cg08523029 chr5:130500466 HINT1 0.42 5.67 0.3 3.18e-8 Pediatric bone mineral content (hip); CRC cis rs9443645 0.901 rs9343860 chr6:79739010 G/A cg05283184 chr6:79620031 NA -0.62 -9.73 -0.47 7.88e-20 Intelligence (multi-trait analysis); CRC cis rs599083 0.530 rs546803 chr11:68186392 C/T cg01657329 chr11:68192670 LRP5 0.5 7.11 0.37 7.09e-12 Bone mineral density (spine); CRC cis rs25422 0.938 rs9489443 chr6:118886163 T/A cg01339444 chr6:118972232 C6orf204 0.53 6.02 0.31 4.77e-9 Renal cell carcinoma; CRC cis rs4481887 0.962 rs4369256 chr1:248492274 G/A cg00666640 chr1:248458726 OR2T12 0.54 9.36 0.46 1.28e-18 Common traits (Other); CRC cis rs10504229 0.679 rs73681882 chr8:58030038 A/G cg22535103 chr8:58192502 C8orf71 -0.44 -5.81 -0.3 1.51e-8 Developmental language disorder (linguistic errors); CRC cis rs17401966 0.522 rs17396973 chr1:10334924 C/T cg19773385 chr1:10388646 KIF1B -0.48 -7.62 -0.39 2.76e-13 Hepatocellular carcinoma; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg19917030 chr17:27507520 MYO18A 0.42 6.04 0.32 4.28e-9 Anxiety disorder; CRC cis rs9811920 0.609 rs4244713 chr3:99679584 T/G cg07805332 chr3:99536008 MIR548G;C3orf26 0.51 7.66 0.39 2.03e-13 Axial length; CRC cis rs7927592 0.956 rs2155730 chr11:68329474 T/C cg16797656 chr11:68205561 LRP5 0.36 5.82 0.31 1.38e-8 Total body bone mineral density; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg00655702 chr15:91478531 UNC45A 0.44 6.12 0.32 2.65e-9 Anxiety disorder; CRC cis rs9322193 0.887 rs11155662 chr6:149913867 T/G cg07701084 chr6:150067640 NUP43 0.54 7.42 0.38 1e-12 Lung cancer; CRC cis rs4481887 0.893 rs10158180 chr1:248481423 C/T cg00666640 chr1:248458726 OR2T12 0.48 8.25 0.41 3.83e-15 Common traits (Other); CRC cis rs853679 0.550 rs1233707 chr6:28172953 G/A cg25164649 chr6:28176230 NA 0.78 10.96 0.52 4.9299999999999996e-24 Depression; CRC cis rs7772486 0.875 rs2814872 chr6:146310234 T/C cg13319975 chr6:146136371 FBXO30 -0.39 -5.87 -0.31 1.08e-8 Lobe attachment (rater-scored or self-reported); CRC cis rs6951245 0.580 rs78894484 chr7:1138721 T/G cg21664854 chr7:1097933 C7orf50;GPR146 0.62 7.76 0.39 1.1e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs9467711 0.606 rs9393714 chr6:26373740 G/T cg14345882 chr6:26364793 BTN3A2 0.64 5.64 0.3 3.62e-8 Autism spectrum disorder or schizophrenia; CRC cis rs1707322 0.752 rs28890893 chr1:46186576 T/G cg06784218 chr1:46089804 CCDC17 0.65 12.05 0.55 5.8e-28 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs155076 1.000 rs598754 chr13:21845010 C/A cg25811766 chr13:21894605 NA -0.57 -5.89 -0.31 9.45e-9 White matter hyperintensity burden; CRC cis rs9457247 0.871 rs1811121 chr6:167403539 T/C cg23791538 chr6:167370224 RNASET2 -0.38 -5.94 -0.31 7.07e-9 Crohn's disease; CRC cis rs666930 0.519 rs477992 chr1:120257576 A/G cg19096424 chr1:120255104 PHGDH 0.56 8.02 0.4 1.93e-14 Breast cancer; CRC cis rs6120849 0.586 rs2025096 chr20:33540000 G/A cg24642439 chr20:33292090 TP53INP2 0.46 6.14 0.32 2.38e-9 Protein C levels; CRC cis rs4665809 1.000 rs6546728 chr2:26276531 G/C cg27170947 chr2:26402098 FAM59B -0.45 -5.63 -0.3 3.94e-8 Gut microbiome composition (summer); CRC cis rs1760803 0.754 rs6719 chr1:154179679 T/C cg26808167 chr1:154192205 UBAP2L;C1orf43 -0.34 -5.88 -0.31 9.99e-9 Nicotine dependence; CRC cis rs3749237 0.555 rs2117939 chr3:49415179 C/A cg03060546 chr3:49711283 APEH 0.64 10.92 0.52 7.04e-24 Resting heart rate; CRC cis rs7829975 0.742 rs12547493 chr8:8661534 C/T cg06636001 chr8:8085503 FLJ10661 -0.6 -9.18 -0.45 5.05e-18 Mood instability; CRC cis rs883565 0.740 rs6599003 chr3:39093326 A/G cg01426195 chr3:39028469 NA 0.52 8.48 0.42 7.88e-16 Handedness; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg00502963 chr1:150488444 NA 0.38 6.36 0.33 6.83e-10 Liver disease severity in Alagille syndrome; CRC cis rs853679 0.760 rs9468317 chr6:28198456 A/G cg15845792 chr6:28175446 NA 0.74 8.18 0.41 6.45e-15 Depression; CRC cis rs11764590 0.694 rs7801349 chr7:2085553 T/C cg23422044 chr7:1970798 MAD1L1 -0.42 -5.96 -0.31 6.62e-9 Neuroticism; CRC cis rs9399135 0.636 rs7749106 chr6:135268142 G/A cg22676075 chr6:135203613 NA 0.45 6.79 0.35 5.25e-11 Red blood cell count; CRC cis rs9811920 0.541 rs1016914 chr3:99640121 C/T cg07805332 chr3:99536008 MIR548G;C3orf26 -0.51 -7.68 -0.39 1.84e-13 Axial length; CRC cis rs10229583 0.527 rs7783478 chr7:127328537 T/C cg01233922 chr7:127693937 SND1 -0.49 -7.05 -0.36 1.03e-11 Type 2 diabetes; CRC cis rs4594175 0.926 rs114230179 chr14:51601974 C/T cg23942311 chr14:51606299 NA 0.67 11.22 0.53 5.79e-25 Cancer; CRC cis rs2854207 0.505 rs2466957 chr17:61961230 G/C cg23090583 chr17:61904693 PSMC5;FTSJ3 0.46 5.7 0.3 2.61e-8 Height; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg10909163 chr13:41635251 WBP4 0.43 6.39 0.33 5.68e-10 Intelligence (multi-trait analysis); CRC cis rs4713118 0.911 rs2394000 chr6:27686991 A/G cg26587870 chr6:27730563 NA -0.43 -6.37 -0.33 6.38e-10 Parkinson's disease; CRC cis rs2075371 0.863 rs12707139 chr7:133954153 A/G cg02659138 chr7:134003124 SLC35B4 0.39 6.62 0.34 1.46e-10 Mean platelet volume; CRC cis rs6764363 0.527 rs4684328 chr3:275101 T/C cg02057681 chr3:285234 CHL1 0.4 6.71 0.35 8.69e-11 Sudden cardiac arrest; CRC cis rs7605378 0.528 rs281780 chr2:200756331 G/C cg23649088 chr2:200775458 C2orf69 0.71 11.55 0.54 3.96e-26 Osteoporosis; CRC cis rs858239 0.899 rs7794684 chr7:23310805 A/G cg00469287 chr7:23338798 C7orf30 0.5 6.35 0.33 6.96e-10 Cerebrospinal fluid biomarker levels; CRC cis rs11229555 0.645 rs72917641 chr11:58227320 A/C cg15696309 chr11:58395628 NA -0.91 -11.54 -0.54 4.09e-26 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; CRC cis rs929596 0.603 rs2602363 chr2:234520525 T/C cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.43 -5.7 -0.3 2.62e-8 Total bilirubin levels in HIV-1 infection; CRC trans rs1814175 0.817 rs10769641 chr11:49960141 A/G cg03929089 chr4:120376271 NA -0.94 -17.92 -0.7 1.32e-50 Height; CRC trans rs62103177 0.810 rs62103187 chr18:77627633 G/C cg05926928 chr17:57297772 GDPD1 1.06 9.97 0.48 1.21e-20 Opioid sensitivity; CRC cis rs9311474 0.629 rs7639267 chr3:52568805 G/T cg15147215 chr3:52552868 STAB1 -0.79 -16.26 -0.67 5.02e-44 Electroencephalogram traits; CRC cis rs853679 0.517 rs4713137 chr6:28083521 C/G cg15845792 chr6:28175446 NA 1.0 13.1 0.59 7.81e-32 Depression; CRC cis rs9309473 1.000 rs7572722 chr2:73724675 T/C cg20560298 chr2:73613845 ALMS1 -0.47 -5.7 -0.3 2.73e-8 Metabolite levels; CRC cis rs9487051 0.646 rs11153166 chr6:109622494 C/T cg01475377 chr6:109611718 NA 0.36 5.8 0.3 1.53e-8 Reticulocyte fraction of red cells; CRC cis rs9326248 0.530 rs6589576 chr11:116735788 C/G cg26566898 chr11:117069891 TAGLN -0.4 -5.91 -0.31 8.66e-9 Blood protein levels; CRC cis rs2976388 1.000 rs2978982 chr8:143763490 T/C cg22687807 chr8:143858763 LYNX1 -0.38 -6.63 -0.34 1.36e-10 Urinary tract infection frequency; CRC trans rs10504229 0.906 rs7006539 chr8:58178799 A/T cg04077850 chr5:125800366 GRAMD3 0.38 6.28 0.33 1.08e-9 Developmental language disorder (linguistic errors); CRC cis rs2066819 1.000 rs2306693 chr12:56680531 T/C cg26714650 chr12:56694279 CS -1.41 -11.64 -0.54 1.88e-26 Psoriasis vulgaris; CRC cis rs6088590 0.965 rs910869 chr20:33292777 C/T cg08999081 chr20:33150536 PIGU 0.53 9.0 0.44 1.85e-17 Coronary artery disease; CRC cis rs7647973 0.769 rs6446204 chr3:49034879 T/C cg20833759 chr3:49053208 WDR6;DALRD3 0.75 11.36 0.53 1.84e-25 Menarche (age at onset); CRC cis rs2072510 0.643 rs2367755 chr12:96393082 T/C cg15438951 chr12:96389694 HAL -0.41 -5.62 -0.3 4.08e-8 Metabolite levels (small molecules and protein measures); CRC trans rs2228479 0.867 rs57940434 chr16:89975496 G/A cg24644049 chr4:85504048 CDS1 0.74 7.25 0.37 2.95e-12 Skin colour saturation; CRC cis rs877282 0.945 rs71489301 chr10:770191 A/G cg17470449 chr10:769945 NA 0.61 8.72 0.43 1.36e-16 Uric acid levels; CRC cis rs10504229 1.000 rs17816781 chr8:58186161 A/T cg05313129 chr8:58192883 C8orf71 -0.47 -6.99 -0.36 1.49e-11 Developmental language disorder (linguistic errors); CRC cis rs6933660 0.646 rs9383899 chr6:151781022 G/C cg10883421 chr6:151773342 RMND1;C6orf211 0.7 11.68 0.54 1.3e-26 Menarche (age at onset); CRC trans rs9393777 0.778 rs35526527 chr6:27042287 C/A cg06606381 chr12:133084897 FBRSL1 -0.84 -6.56 -0.34 2.11e-10 Intelligence (multi-trait analysis); CRC cis rs6951245 0.554 rs11544331 chr7:1131411 C/T cg22907277 chr7:1156413 C7orf50 0.86 11.15 0.52 1.05e-24 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs875971 0.545 rs10261710 chr7:65714189 T/A cg18876405 chr7:65276391 NA 0.44 6.13 0.32 2.53e-9 Aortic root size; CRC cis rs427941 0.668 rs201461 chr7:101741625 T/C cg06246474 chr7:101738831 CUX1 0.46 7.24 0.37 3.2e-12 Plasma omega-3 polyunsaturated fatty acid level (eicosapentaenoic acid); CRC cis rs12144094 1.000 rs41276626 chr1:120262112 G/A cg20995928 chr1:120229863 NA 0.48 5.8 0.3 1.58e-8 Height; CRC cis rs4862750 0.872 rs6553029 chr4:187876470 G/T cg10295955 chr4:187884368 NA 1.01 24.19 0.8 5.53e-75 Lobe attachment (rater-scored or self-reported); CRC cis rs7809950 0.817 rs2237678 chr7:107203265 T/G cg23024343 chr7:107201750 COG5 -0.79 -10.62 -0.51 7.77e-23 Coronary artery disease; CRC cis rs826838 0.935 rs1160162 chr12:38959795 G/A cg26384229 chr12:38710491 ALG10B 0.72 10.03 0.48 7.86e-21 Heart rate; CRC cis rs1322512 1.000 rs2758812 chr6:152965908 C/T cg03415253 chr6:152958462 SYNE1 -0.42 -6.53 -0.34 2.55e-10 Tonometry; CRC cis rs425277 1.000 rs381664 chr1:2088104 A/G cg24578937 chr1:2090814 PRKCZ 0.66 11.71 0.54 1.02e-26 Height; CRC cis rs10782582 0.609 rs5745325 chr1:76269460 G/A cg03433033 chr1:76189801 ACADM -0.4 -5.79 -0.3 1.68e-8 Daytime sleep phenotypes; CRC cis rs7626444 0.605 rs7642801 chr3:196490306 G/C cg12930392 chr3:196481615 PAK2 0.39 6.92 0.36 2.43e-11 Monocyte count; CRC cis rs2739330 0.731 rs5751792 chr22:24401542 G/A cg15242686 chr22:24348715 GSTTP1 0.54 8.88 0.44 4.31e-17 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs13108904 0.557 rs1250086 chr4:1248051 G/A cg21620606 chr4:1342894 KIAA1530 -0.44 -7.12 -0.37 6.88e-12 Obesity-related traits; CRC cis rs2227564 0.794 rs2688624 chr10:75695724 T/G cg00564723 chr10:75632066 CAMK2G -0.31 -7.12 -0.37 6.94e-12 Crohn's disease;Inflammatory bowel disease; CRC cis rs9911578 1.000 rs304296 chr17:56834229 G/T cg05425664 chr17:57184151 TRIM37 -0.49 -7.68 -0.39 1.86e-13 Intelligence (multi-trait analysis); CRC cis rs12410462 1.000 rs16847833 chr1:227626662 G/A cg23173402 chr1:227635558 NA 0.7 7.89 0.4 4.61e-14 Major depressive disorder; CRC cis rs4824093 0.610 rs77128035 chr22:50241024 C/T cg22709217 chr22:50311962 ALG12;CRELD2 -0.93 -7.79 -0.39 8.81e-14 Amyotrophic lateral sclerosis (sporadic); CRC cis rs612683 0.524 rs479269 chr1:100887616 A/G cg06223162 chr1:101003688 GPR88 0.39 6.95 0.36 1.92e-11 Breast cancer; CRC cis rs11971779 0.648 rs6947309 chr7:139035830 C/T cg23387468 chr7:139079360 LUC7L2 0.4 6.97 0.36 1.72e-11 Diisocyanate-induced asthma; CRC cis rs17666538 0.585 rs4735812 chr8:607766 C/G cg10396713 chr8:602097 NA 0.58 5.84 0.31 1.27e-8 IgG glycosylation; CRC cis rs3096299 0.685 rs12446145 chr16:89542695 C/T cg00750074 chr16:89608354 SPG7 -0.52 -8.06 -0.41 1.47e-14 Multiple myeloma (IgH translocation); CRC cis rs12545109 0.643 rs1119707 chr8:57411548 T/C cg09654669 chr8:57350985 NA -0.4 -5.68 -0.3 2.99e-8 Obesity-related traits; CRC cis rs34375054 0.526 rs34764657 chr12:125679639 A/G cg06287003 chr12:125626642 AACS -0.52 -7.03 -0.36 1.18e-11 Post bronchodilator FEV1/FVC ratio; CRC cis rs4780401 0.609 rs16958588 chr16:11819330 G/A cg01061890 chr16:11836724 TXNDC11 -0.61 -9.14 -0.45 6.56e-18 Rheumatoid arthritis; CRC cis rs2046867 0.862 rs67961837 chr3:72840877 T/G cg25664220 chr3:72788482 NA -0.44 -6.19 -0.32 1.79e-9 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; CRC cis rs3771570 0.681 rs12151655 chr2:242281438 T/A cg21155796 chr2:242212141 HDLBP 0.64 6.98 0.36 1.63e-11 Prostate cancer; CRC cis rs2842992 0.872 rs9456440 chr6:160074463 G/T cg11366901 chr6:160182831 ACAT2 0.85 11.25 0.53 4.59e-25 Age-related macular degeneration (geographic atrophy); CRC cis rs6920965 0.507 rs9401853 chr6:126215197 A/T cg05901451 chr6:126070800 HEY2 -0.41 -6.25 -0.33 1.29e-9 High light scatter reticulocyte count; CRC cis rs1691799 0.899 rs1168321 chr12:66744517 C/G cg16791601 chr12:66731901 HELB 0.73 12.97 0.58 2.38e-31 White blood cell count (basophil); CRC cis rs13082711 0.871 rs34209332 chr3:27434061 A/T cg02860705 chr3:27208620 NA 0.62 8.88 0.44 4.31e-17 Systolic blood pressure;Diastolic blood pressure;Blood pressure; CRC cis rs9942416 0.660 rs4704231 chr5:74986576 G/A cg19683494 chr5:74908142 NA 0.5 6.28 0.33 1.06e-9 Age-related disease endophenotypes; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg25698102 chr12:57472712 TMEM194A 0.43 6.31 0.33 9.04e-10 Intelligence (multi-trait analysis); CRC cis rs4689388 0.926 rs11725494 chr4:6293855 C/T cg14416269 chr4:6271139 WFS1 0.36 5.97 0.31 6.1e-9 Type 2 diabetes and other traits;Type 2 diabetes; CRC cis rs4332037 0.707 rs62435132 chr7:1891315 C/T cg25834613 chr7:1915315 MAD1L1 -0.4 -6.21 -0.32 1.56e-9 Bipolar disorder; CRC cis rs11971779 0.584 rs10236055 chr7:139069991 A/G cg07862535 chr7:139043722 LUC7L2 0.57 7.35 0.38 1.61e-12 Diisocyanate-induced asthma; CRC cis rs6840360 0.582 rs2709827 chr4:152331252 G/C cg09659197 chr4:152720779 NA 0.29 5.66 0.3 3.3e-8 Intelligence (multi-trait analysis); CRC cis rs2153535 0.601 rs9505473 chr6:8538777 T/C cg21535247 chr6:8435926 SLC35B3 0.51 7.81 0.4 7.77e-14 Motion sickness; CRC cis rs1448094 0.967 rs10746357 chr12:86341044 A/T cg02569458 chr12:86230093 RASSF9 0.39 6.77 0.35 6.09e-11 Major depressive disorder; CRC cis rs17376456 0.569 rs6556834 chr5:93123067 C/T cg25358565 chr5:93447407 FAM172A -0.6 -7.06 -0.36 9.73e-12 Diabetic retinopathy; CRC cis rs600231 0.665 rs2846861 chr11:65222305 A/G cg17120908 chr11:65337727 SSSCA1 -0.55 -8.22 -0.41 4.67e-15 Bone mineral density; CRC trans rs9341835 0.772 rs9341841 chr6:64135010 G/A cg13657004 chr13:50234944 EBPL -0.37 -6.4 -0.33 5.31e-10 Schizophrenia; CRC cis rs889398 0.677 rs68161338 chr16:69823778 T/G cg00738113 chr16:70207722 CLEC18C 0.37 6.13 0.32 2.47e-9 Body mass index; CRC cis rs66887589 0.807 rs7694483 chr4:120405929 T/A cg09307838 chr4:120376055 NA 0.52 8.24 0.41 4.08e-15 Diastolic blood pressure; CRC cis rs7635838 0.819 rs4684782 chr3:11518755 C/T cg00170343 chr3:11313890 ATG7 -0.43 -6.52 -0.34 2.58e-10 HDL cholesterol; CRC cis rs11098499 0.865 rs28845498 chr4:120405186 G/A cg24375607 chr4:120327624 NA 0.49 7.68 0.39 1.78e-13 Corneal astigmatism; CRC cis rs1862618 0.853 rs11739344 chr5:56111087 A/C cg24531977 chr5:56204891 C5orf35 -0.84 -11.16 -0.52 9.37e-25 Initial pursuit acceleration; CRC cis rs9894429 1.000 rs7222241 chr17:79574714 C/G cg18240062 chr17:79603768 NPLOC4 0.55 9.24 0.45 3.27e-18 Eye color traits; CRC cis rs10992471 0.702 rs10120915 chr9:95547725 A/C cg14631576 chr9:95140430 CENPP -0.33 -6.14 -0.32 2.41e-9 Visceral adipose tissue/subcutaneous adipose tissue ratio; CRC cis rs875971 0.862 rs6947339 chr7:65888470 T/C cg18876405 chr7:65276391 NA 0.54 8.71 0.43 1.49e-16 Aortic root size; CRC cis rs9318086 0.648 rs35449605 chr13:24472582 G/A cg25267304 chr13:24462978 PCOTH;MIPEP 0.65 10.41 0.5 3.96e-22 Myopia (pathological); CRC cis rs270601 0.710 rs4705852 chr5:131602807 A/G cg09877947 chr5:131593287 PDLIM4 0.53 9.94 0.48 1.53e-20 Acylcarnitine levels; CRC cis rs67311347 1.000 rs11714032 chr3:40431605 G/A cg09455208 chr3:40491958 NA 0.49 9.32 0.46 1.73e-18 Renal cell carcinoma; CRC cis rs10028773 0.700 rs35653026 chr4:120248378 A/G cg24375607 chr4:120327624 NA 0.46 7.05 0.36 1.03e-11 Educational attainment; CRC cis rs10504229 0.683 rs55660024 chr8:58128943 G/A cg02290350 chr8:58132656 NA -0.58 -8.16 -0.41 7.29e-15 Developmental language disorder (linguistic errors); CRC cis rs6964587 0.839 rs6950538 chr7:91417816 T/C cg17063962 chr7:91808500 NA 0.67 10.45 0.5 2.86e-22 Breast cancer; CRC cis rs10540 1.000 rs12801148 chr11:511707 T/G cg08200582 chr11:442649 ANO9 -0.71 -7.39 -0.38 1.2e-12 Body mass index; CRC cis rs9303401 0.659 rs72828726 chr17:56951217 C/G cg02118635 chr17:56770003 RAD51C;TEX14 0.8 10.2 0.49 2.12e-21 Cognitive test performance; CRC cis rs501120 0.657 rs11238908 chr10:44688080 T/G cg09554077 chr10:44749378 NA 0.57 6.55 0.34 2.2e-10 Coronary artery disease;Coronary heart disease; CRC cis rs1218582 0.741 rs6656494 chr1:154839799 A/G cg03351412 chr1:154909251 PMVK 0.53 8.54 0.43 4.99e-16 Prostate cancer; CRC cis rs8060686 0.516 rs7187202 chr16:68273895 T/C cg26727032 chr16:67993705 SLC12A4 -0.63 -9.12 -0.45 7.9e-18 HDL cholesterol;Metabolic syndrome; CRC cis rs9322193 0.924 rs9322189 chr6:149909933 T/C cg05861140 chr6:150128134 PCMT1 -0.37 -5.9 -0.31 8.82e-9 Lung cancer; CRC trans rs11039798 0.512 rs3974936 chr11:49005012 C/T cg03929089 chr4:120376271 NA 0.61 6.26 0.33 1.19e-9 Axial length; CRC cis rs6952808 0.825 rs34296663 chr7:1935245 C/T cg00106254 chr7:1943704 MAD1L1 -0.52 -7.71 -0.39 1.5e-13 Bipolar disorder and schizophrenia; CRC trans rs4869931 0.929 rs58824807 chr6:151006270 T/C cg01367992 chr1:160766535 LY9 0.38 6.17 0.32 1.98e-9 Systolic blood pressure in sickle cell anemia; CRC cis rs25422 0.878 rs55894300 chr6:118982076 T/A cg15382696 chr6:118971807 C6orf204 0.62 7.43 0.38 9.18e-13 Renal cell carcinoma; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg06192289 chr12:102513805 NUP37;C12orf48 0.38 6.14 0.32 2.41e-9 Liver disease severity in Alagille syndrome; CRC cis rs370915 0.524 rs28826385 chr4:187769452 C/T cg12892747 chr4:187813459 NA -0.56 -8.19 -0.41 5.73e-15 Gout; CRC cis rs7259376 0.936 rs6511344 chr19:22535673 C/T cg02657401 chr19:22469223 NA -0.33 -7.46 -0.38 7.6e-13 Menopause (age at onset); CRC cis rs1218582 0.772 rs10908448 chr1:154882544 A/G cg16680214 chr1:154839983 KCNN3 0.46 9.05 0.45 1.32e-17 Prostate cancer; CRC cis rs7843479 0.601 rs727693 chr8:21850116 A/G cg16476235 chr8:21771668 DOK2 0.39 6.54 0.34 2.37e-10 Mean corpuscular volume; CRC cis rs861020 0.771 rs629150 chr1:209998467 C/T cg05527609 chr1:210001259 C1orf107 1.08 14.88 0.63 1.19e-38 Orofacial clefts; CRC cis rs10206020 0.885 rs6720797 chr2:1574340 T/C cg12573674 chr2:1569213 NA -0.78 -10.56 -0.5 1.19e-22 IgG glycosylation; CRC cis rs9398803 0.965 rs6907898 chr6:126666416 C/T cg19875578 chr6:126661172 C6orf173 0.41 5.64 0.3 3.69e-8 Male-pattern baldness; CRC cis rs4319547 0.774 rs7295105 chr12:123124225 G/A cg23029597 chr12:123009494 RSRC2 -0.53 -6.95 -0.36 1.95e-11 Body mass index; CRC cis rs79349575 0.783 rs4794000 chr17:47022755 C/G cg00947319 chr17:47005597 UBE2Z -0.34 -5.89 -0.31 9.32e-9 Type 2 diabetes; CRC cis rs3858526 0.883 rs10769333 chr11:5939685 A/T cg13902645 chr11:5959945 NA -0.61 -8.45 -0.42 9.45e-16 DNA methylation (variation); CRC cis rs5769765 0.773 rs9616208 chr22:50313359 G/A cg02269571 chr22:50332266 NA -0.6 -7.83 -0.4 6.64e-14 Schizophrenia; CRC cis rs2439831 0.867 rs2447208 chr15:43933895 C/T cg02155558 chr15:43621948 ADAL;LCMT2 0.67 7.54 0.38 4.63e-13 Lung cancer in ever smokers; CRC cis rs9916302 0.904 rs588193 chr17:37440439 A/C cg00129232 chr17:37814104 STARD3 0.54 7.97 0.4 2.61e-14 Glomerular filtration rate (creatinine); CRC cis rs67340775 0.541 rs200966 chr6:27862152 T/C cg03623178 chr6:28175578 NA 0.87 9.3 0.46 1.95e-18 Lung cancer in ever smokers; CRC cis rs4664293 0.802 rs7563417 chr2:160584273 A/C cg08347373 chr2:160653686 CD302 -0.49 -7.7 -0.39 1.64e-13 Monocyte percentage of white cells; CRC cis rs875971 0.929 rs34406470 chr7:65929956 A/G cg11764359 chr7:65958608 NA 0.62 9.94 0.48 1.55e-20 Aortic root size; CRC cis rs3020333 0.875 rs2941740 chr6:152009638 A/G cg22157087 chr6:152012887 ESR1 0.53 7.86 0.4 5.43e-14 Total body bone mineral density; CRC cis rs2072499 0.966 rs1137703 chr1:156184458 T/C cg25208724 chr1:156163844 SLC25A44 1.08 24.93 0.81 8.84e-78 Testicular germ cell tumor; CRC cis rs2228479 0.867 rs11646448 chr16:89966357 A/T cg04013166 chr16:89971882 TCF25 0.57 5.82 0.31 1.43e-8 Skin colour saturation; CRC cis rs11622475 1.000 rs2273610 chr14:104387642 G/C cg12183467 chr14:104352244 NA -0.51 -7.0 -0.36 1.43e-11 Bipolar disorder; CRC cis rs2404602 0.735 rs12903874 chr15:76693318 A/T cg03037974 chr15:76606532 NA -0.5 -7.43 -0.38 9.44e-13 Blood metabolite levels; CRC cis rs9368481 0.761 rs4358615 chr6:26998567 A/G cg18278486 chr6:26987575 LOC100270746;C6orf41 0.43 6.96 0.36 1.81e-11 Autism spectrum disorder or schizophrenia; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg20706768 chr7:55225183 EGFR -0.37 -6.26 -0.33 1.18e-9 Liver disease severity in Alagille syndrome; CRC cis rs6570726 0.791 rs952406 chr6:145925616 C/A cg13319975 chr6:146136371 FBXO30 -0.42 -6.29 -0.33 1.01e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs10256972 0.591 rs10229680 chr7:1158565 C/T cg09177884 chr7:1199841 ZFAND2A -0.44 -6.29 -0.33 1.02e-9 Longevity;Endometriosis; CRC cis rs9322193 0.884 rs10782312 chr6:149943805 G/T cg13206674 chr6:150067644 NUP43 0.65 9.76 0.47 6.33e-20 Lung cancer; CRC cis rs1552244 0.572 rs58223482 chr3:10169746 G/C cg08888203 chr3:10149979 C3orf24 0.71 8.58 0.43 3.91e-16 Alzheimer's disease; CRC cis rs10504229 1.000 rs76944716 chr8:58191643 T/C cg22535103 chr8:58192502 C8orf71 -0.81 -11.71 -0.54 1.03e-26 Developmental language disorder (linguistic errors); CRC cis rs2275731 0.506 rs7905643 chr10:16521007 T/G cg04254609 chr10:16479192 PTER -0.47 -6.45 -0.34 3.9e-10 Bone fracture in osteoporosis; CRC cis rs4423214 0.879 rs10898144 chr11:71151540 A/T cg05163923 chr11:71159392 DHCR7 -0.65 -8.25 -0.41 3.91e-15 Vitamin D levels; CRC cis rs853679 0.599 rs149943 chr6:28002388 G/A cg15845792 chr6:28175446 NA 0.71 6.59 0.34 1.77e-10 Depression; CRC cis rs265548 0.646 rs36689 chr19:17910639 A/G cg16024904 chr19:17905718 B3GNT3 0.36 5.68 0.3 2.92e-8 Tumor biomarkers; CRC cis rs743757 1.000 rs1107265 chr3:50431995 A/C cg09545109 chr3:50388910 TUSC4;CYB561D2 0.43 6.32 0.33 8.56e-10 Diastolic blood pressure; CRC cis rs10540 0.908 rs35608427 chr11:498976 T/C cg21784768 chr11:537496 LRRC56 -0.68 -6.45 -0.33 4.1e-10 Body mass index; CRC cis rs11676855 0.927 rs4341884 chr2:235918504 G/T cg14917874 chr2:235941519 SH3BP4 0.43 6.06 0.32 3.68e-9 Dialysis-related mortality; CRC cis rs10760158 0.832 rs4836845 chr9:124049956 T/C cg14417974 chr9:124058376 GSN -0.34 -5.81 -0.31 1.48e-8 Pulse pressure; CRC cis rs4731207 0.698 rs17147583 chr7:124470125 C/G cg23710748 chr7:124431027 NA 0.38 6.08 0.32 3.42e-9 Cutaneous malignant melanoma; CRC cis rs7618915 0.547 rs34215106 chr3:52659124 T/C cg11645453 chr3:52864694 ITIH4 0.35 6.2 0.32 1.73e-9 Bipolar disorder; CRC trans rs660498 0.785 rs2484203 chr10:27736292 C/T cg13661793 chr10:32399026 NA -0.33 -5.99 -0.31 5.65e-9 Asthma (childhood onset); CRC cis rs769267 0.965 rs4808200 chr19:19554803 C/T cg03709012 chr19:19516395 GATAD2A 0.71 10.78 0.51 2.03e-23 Tonsillectomy; CRC cis rs4862750 0.872 rs6811569 chr4:187897988 A/G cg06074448 chr4:187884817 NA 0.6 10.89 0.51 8.63e-24 Lobe attachment (rater-scored or self-reported); CRC cis rs4713118 0.868 rs9468220 chr6:27732976 A/G cg15786705 chr6:28176104 NA -0.6 -6.67 -0.34 1.11e-10 Parkinson's disease; CRC cis rs25422 0.887 rs9320666 chr6:118989181 C/T cg24463073 chr6:118973353 C6orf204 0.42 5.99 0.31 5.54e-9 Renal cell carcinoma; CRC cis rs965469 0.779 rs6037571 chr20:3334322 C/T cg25506879 chr20:3388711 C20orf194 -0.37 -5.77 -0.3 1.84e-8 IFN-related cytopenia; CRC cis rs10504229 0.683 rs59679713 chr8:58134370 G/C cg02725872 chr8:58115012 NA -0.64 -11.49 -0.53 6.67e-26 Developmental language disorder (linguistic errors); CRC cis rs9399135 0.967 rs4895436 chr6:135295001 G/A cg24558204 chr6:135376177 HBS1L 0.5 7.82 0.4 7.14e-14 Red blood cell count; CRC cis rs5753618 0.561 rs9606831 chr22:31732512 C/T cg22777020 chr22:31556080 RNF185 0.56 6.47 0.34 3.64e-10 Colorectal cancer; CRC cis rs2991971 0.934 rs2991974 chr1:46020654 A/G cg03123370 chr1:45965343 CCDC163P;MMACHC -0.39 -5.74 -0.3 2.11e-8 High light scatter reticulocyte count; CRC cis rs9814567 1.000 rs9809619 chr3:134280948 G/T cg06109529 chr3:134205091 CEP63;ANAPC13 -0.81 -12.31 -0.56 6.78e-29 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs7762018 1.000 rs41265383 chr6:170068025 T/C cg24289452 chr6:170231220 NA -0.57 -6.21 -0.32 1.6e-9 Thiazide-induced adverse metabolic effects in hypertensive patients; CRC cis rs7635838 0.617 rs346074 chr3:11294310 T/C cg00170343 chr3:11313890 ATG7 0.58 9.04 0.45 1.4e-17 HDL cholesterol; CRC cis rs9311676 0.618 rs12152336 chr3:58365146 T/A cg06643156 chr3:58380774 PXK 0.42 6.55 0.34 2.17e-10 Systemic lupus erythematosus; CRC cis rs28386778 0.830 rs2665798 chr17:61921397 C/T cg06873352 chr17:61820015 STRADA 0.76 14.12 0.61 1.01e-35 Prudent dietary pattern; CRC cis rs2204008 0.729 rs2892365 chr12:38446760 G/C cg26384229 chr12:38710491 ALG10B -0.65 -9.65 -0.47 1.46e-19 Bladder cancer; CRC cis rs12745968 0.589 rs6603989 chr1:93026928 G/T cg17283838 chr1:93427260 FAM69A -0.48 -6.32 -0.33 8.29e-10 Bipolar disorder and schizophrenia; CRC cis rs12594515 1.000 rs8033148 chr15:45997929 G/A cg22117107 chr15:45993392 NA -0.43 -8.65 -0.43 2.36e-16 Waist circumference;Weight; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg26909954 chr8:127570872 FAM84B 0.42 6.11 0.32 2.81e-9 Response to antipsychotic treatment; CRC cis rs7523050 0.643 rs7551142 chr1:109399710 G/T cg08274380 chr1:109419600 GPSM2 0.84 6.6 0.34 1.69e-10 Fat distribution (HIV); CRC cis rs1552244 1.000 rs17032414 chr3:10158302 C/G cg13047869 chr3:10149882 C3orf24 0.5 7.09 0.36 8.03e-12 Alzheimer's disease; CRC cis rs1005277 0.540 rs7903942 chr10:37929276 C/T cg25427524 chr10:38739819 LOC399744 0.7 11.82 0.55 4.31e-27 Extrinsic epigenetic age acceleration; CRC cis rs56307353 0.753 rs34318825 chr19:1961342 T/C cg05502645 chr19:1971281 CSNK1G2 0.46 7.29 0.37 2.25e-12 Coronary artery disease; CRC cis rs4272321 1 rs4272321 chr7:157951835 A/G cg09742643 chr7:157958748 PTPRN2 0.36 6.04 0.32 4.14e-9 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; CRC cis rs9303401 0.659 rs17822837 chr17:56737838 C/T cg02118635 chr17:56770003 RAD51C;TEX14 0.76 9.14 0.45 6.58e-18 Cognitive test performance; CRC cis rs12701220 0.894 rs12701348 chr7:1039457 C/T cg26769984 chr7:1090371 C7orf50 0.63 8.79 0.44 8.38e-17 Bronchopulmonary dysplasia; CRC trans rs1612141 0.901 rs1112504 chr14:41709711 G/T cg23649140 chr8:37661612 GPR124 0.46 6.08 0.32 3.37e-9 QT interval (drug interaction); CRC cis rs9486719 0.895 rs3734239 chr6:96996244 A/G cg18709589 chr6:96969512 KIAA0776 -0.53 -5.98 -0.31 5.81e-9 Migraine;Coronary artery disease; CRC cis rs6747952 0.899 rs2880132 chr2:239082976 G/A cg07480446 chr2:239069576 NA -0.37 -6.8 -0.35 4.82e-11 Mean corpuscular hemoglobin concentration; CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg16714605 chr19:10765132 ILF3;LOC147727 0.36 6.27 0.33 1.15e-9 Obesity-related traits; CRC cis rs6424115 0.931 rs2982390 chr1:24147830 G/C cg09473613 chr1:24152604 HMGCL 0.35 5.78 0.3 1.73e-8 Immature fraction of reticulocytes; CRC cis rs17253792 0.822 rs78988988 chr14:56152404 G/A cg01858014 chr14:56050164 KTN1 -0.87 -7.03 -0.36 1.17e-11 Putamen volume; CRC cis rs3806843 0.549 rs246012 chr5:140336277 C/T cg19875535 chr5:140030758 IK 0.4 6.12 0.32 2.64e-9 Depressive symptoms (multi-trait analysis); CRC cis rs12230513 0.732 rs59438785 chr12:55811665 A/G cg19537932 chr12:55886519 OR6C68 -0.74 -9.46 -0.46 5.95e-19 Contrast sensitivity; CRC cis rs11098499 0.954 rs13113483 chr4:120309039 C/T cg09307838 chr4:120376055 NA 0.71 10.93 0.52 6.41e-24 Corneal astigmatism; CRC cis rs933688 0.938 rs6866923 chr5:90669352 A/C cg26981201 chr5:90679533 LOC100129716;ARRDC3 1.07 17.74 0.7 7.17e-50 Smoking behavior; CRC cis rs1552244 0.554 rs7638846 chr3:10048601 A/G cg18598329 chr3:10140678 FANCD2;C3orf24 -0.53 -7.53 -0.38 4.85e-13 Alzheimer's disease; CRC cis rs2576037 0.583 rs644731 chr18:44426877 C/T cg23996704 chr18:44553084 KATNAL2 -0.33 -6.83 -0.35 4.07e-11 Personality dimensions; CRC cis rs2235544 0.579 rs1537322 chr1:54482306 G/T cg25741118 chr1:54482237 LDLRAD1 -0.21 -6.0 -0.31 5.34e-9 Multiple myeloma (hyperdiploidy);Thyroid hormone levels; CRC cis rs2404602 0.735 rs11632222 chr15:76712927 C/G cg03037974 chr15:76606532 NA -0.52 -7.35 -0.38 1.54e-12 Blood metabolite levels; CRC cis rs7615952 0.599 rs12485717 chr3:125707075 C/T cg05084668 chr3:125655381 ALG1L 0.46 6.49 0.34 3.08e-10 Blood pressure (smoking interaction); CRC cis rs754466 0.580 rs10824573 chr10:79540969 T/C cg17075019 chr10:79541650 NA -0.97 -18.47 -0.71 9.2e-53 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs2243480 0.901 rs35256305 chr7:65306405 T/C cg12463550 chr7:65579703 CRCP 0.66 6.14 0.32 2.36e-9 Diabetic kidney disease; CRC cis rs7666738 0.962 rs11728816 chr4:98951767 C/T cg03676636 chr4:99064102 C4orf37 0.24 6.66 0.34 1.16e-10 Colonoscopy-negative controls vs population controls; CRC cis rs9303280 0.806 rs11078927 chr17:38064405 C/T cg17344932 chr17:38183730 MED24;SNORD124 0.41 6.51 0.34 2.73e-10 Self-reported allergy; CRC cis rs798554 0.679 rs2644281 chr7:2886748 A/G cg19346786 chr7:2764209 NA -0.37 -6.41 -0.33 4.98e-10 Height; CRC cis rs8180040 0.967 rs4858856 chr3:47565424 G/A cg02527881 chr3:46936655 PTH1R -0.39 -7.45 -0.38 8.43e-13 Colorectal cancer; CRC cis rs17376456 0.825 rs10053405 chr5:93275403 A/G cg21475434 chr5:93447410 FAM172A -0.73 -7.53 -0.38 5.09e-13 Diabetic retinopathy; CRC cis rs9649213 0.593 rs11766808 chr7:97915376 A/G cg24562669 chr7:97807699 LMTK2 0.45 7.54 0.38 4.56e-13 Prostate cancer (SNP x SNP interaction); CRC cis rs7824557 0.569 rs35418978 chr8:11186453 T/C cg20542592 chr8:11973495 FAM66D -0.33 -5.64 -0.3 3.69e-8 Retinal vascular caliber; CRC cis rs3806843 0.966 rs10036519 chr5:140151701 C/T cg19875535 chr5:140030758 IK -0.55 -8.71 -0.43 1.5e-16 Depressive symptoms (multi-trait analysis); CRC cis rs294883 0.858 rs2879865 chr6:159718610 T/A cg14500486 chr6:159655392 FNDC1 -0.35 -5.75 -0.3 2.09e-8 Coronary artery disease; CRC cis rs7412746 0.553 rs59337856 chr1:150746406 G/T cg18016565 chr1:150552671 MCL1 0.43 5.95 0.31 6.7e-9 Melanoma; CRC cis rs34779708 0.931 rs7084196 chr10:35367161 T/C cg03585969 chr10:35415529 CREM 0.58 7.82 0.4 7.07e-14 Inflammatory bowel disease;Crohn's disease; CRC cis rs8114671 0.562 rs725521 chr20:33516071 T/C cg07148914 chr20:33460835 GGT7 0.4 6.63 0.34 1.38e-10 Height; CRC cis rs28386778 0.897 rs2584610 chr17:61934783 T/C cg06601766 chr17:61851465 DDX42;CCDC47 0.44 5.94 0.31 7.25e-9 Prudent dietary pattern; CRC cis rs909002 0.800 rs10914459 chr1:32096918 T/C cg01639898 chr1:32083012 HCRTR1 0.32 6.6 0.34 1.63e-10 Intelligence (multi-trait analysis); CRC cis rs6502050 0.761 rs11653003 chr17:80058795 G/T cg22110888 chr17:80059540 CCDC57 -0.44 -6.87 -0.35 3.2e-11 Life satisfaction; CRC cis rs9814567 0.964 rs9820150 chr3:134223011 C/G cg06541857 chr3:134203789 ANAPC13;CEP63 -0.39 -5.78 -0.3 1.73e-8 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs9303280 0.806 rs62067034 chr17:38063738 C/T cg00129232 chr17:37814104 STARD3 -0.52 -8.33 -0.42 2.15e-15 Self-reported allergy; CRC cis rs10504229 0.683 rs7820302 chr8:58142502 C/T cg22535103 chr8:58192502 C8orf71 -0.66 -9.07 -0.45 1.12e-17 Developmental language disorder (linguistic errors); CRC cis rs600806 0.813 rs6664236 chr1:109986672 C/A cg23032129 chr1:109941072 SORT1 -0.28 -5.93 -0.31 7.86e-9 Intelligence (multi-trait analysis); CRC cis rs6546550 0.935 rs2305523 chr2:70039677 G/T cg02498382 chr2:70120550 SNRNP27 0.47 7.87 0.4 5.03e-14 Prevalent atrial fibrillation; CRC cis rs10751667 0.961 rs7943115 chr11:973885 T/C cg01483505 chr11:975446 AP2A2 0.41 6.16 0.32 2.1e-9 Alzheimer's disease (late onset); CRC cis rs12024301 0.557 rs7518362 chr1:183610578 C/T cg11505048 chr1:183622726 RGL1;APOBEC4 0.81 7.0 0.36 1.42e-11 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs2980439 0.525 rs2980508 chr8:8171732 C/T cg06636001 chr8:8085503 FLJ10661 0.49 7.66 0.39 2.13e-13 Neuroticism; CRC cis rs7927771 0.864 rs2293580 chr11:47440283 T/A cg20307385 chr11:47447363 PSMC3 0.59 8.91 0.44 3.52e-17 Subjective well-being; CRC cis rs12220238 1.000 rs1908331 chr10:75885817 G/A cg19889307 chr10:75911429 ADK;AP3M1 0.6 5.95 0.31 6.94e-9 Soluble interleukin-2 receptor subunit alpha; CRC cis rs17270561 0.514 rs10946805 chr6:26077891 C/T cg16482183 chr6:26056742 HIST1H1C 1.11 13.59 0.6 1.11e-33 Iron status biomarkers; CRC cis rs3015497 0.543 rs1565834 chr14:51011528 C/T cg26011998 chr14:51135199 SAV1 0.45 5.65 0.3 3.5e-8 Mean platelet volume; CRC cis rs6908034 0.607 rs77386860 chr6:19814755 A/C cg02682789 chr6:19804855 NA 0.81 6.48 0.34 3.35e-10 Endometriosis;Deep ovarian and/or rectovaginal disease with dense adhesions; CRC cis rs908922 0.676 rs1856119 chr1:152512483 A/G cg23254163 chr1:152506842 NA 0.45 8.85 0.44 5.3e-17 Hair morphology; CRC cis rs7914558 0.966 rs11191438 chr10:104637864 C/G cg15744005 chr10:104629667 AS3MT -0.33 -7.13 -0.37 6.34e-12 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC trans rs4650994 1.000 rs6660445 chr1:178528871 C/T cg05059571 chr16:84539110 KIAA1609 -0.45 -6.82 -0.35 4.36e-11 HDL cholesterol levels;HDL cholesterol; CRC cis rs2985684 0.894 rs6572585 chr14:50021075 A/G cg23565292 chr14:50234668 KLHDC2 -0.41 -5.96 -0.31 6.52e-9 Carotid intima media thickness; CRC cis rs25422 0.938 rs114309775 chr6:118838782 G/A cg22561889 chr6:118971681 C6orf204 0.52 6.69 0.35 9.59e-11 Renal cell carcinoma; CRC trans rs11165623 0.792 rs9437609 chr1:96977961 A/C cg10631902 chr5:14652156 NA -0.48 -8.74 -0.43 1.25e-16 Hip circumference;Waist circumference; CRC trans rs2727020 0.729 rs2204366 chr11:49349367 A/C cg11707556 chr5:10655725 ANKRD33B 0.36 6.82 0.35 4.49e-11 Coronary artery disease; CRC cis rs12477438 0.520 rs34766932 chr2:99737273 G/A cg14399236 chr2:99771627 LIPT1;TSGA10 0.79 13.77 0.6 2.27e-34 Chronic sinus infection; CRC cis rs12893668 0.572 rs1606 chr14:104161281 G/A cg01849466 chr14:104193079 ZFYVE21 -0.41 -6.18 -0.32 1.88e-9 Reticulocyte count; CRC cis rs12497850 0.931 rs1134591 chr3:48972892 C/T cg20833759 chr3:49053208 WDR6;DALRD3 0.52 9.25 0.45 2.91e-18 Parkinson's disease; CRC cis rs9372498 0.505 rs9481811 chr6:118801174 T/C cg24463073 chr6:118973353 C6orf204 0.51 6.69 0.35 9.44e-11 Diastolic blood pressure; CRC cis rs2836633 0.929 rs2836602 chr21:40039169 A/T cg05519781 chr21:40033154 ERG -0.68 -13.45 -0.6 3.72e-33 Coronary artery disease; CRC cis rs4843747 0.671 rs4075998 chr16:88106776 G/A cg03395651 chr16:88107091 BANP 0.6 8.16 0.41 7.06e-15 Menopause (age at onset); CRC cis rs4727027 0.866 rs1405124 chr7:148779618 C/T cg23583168 chr7:148888333 NA -0.89 -15.28 -0.64 3.35e-40 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC cis rs1862618 0.853 rs2548665 chr5:56131805 T/A cg12311346 chr5:56204834 C5orf35 -0.78 -10.28 -0.49 1.11e-21 Initial pursuit acceleration; CRC cis rs9527 0.641 rs10786732 chr10:104762535 T/C cg04362960 chr10:104952993 NT5C2 0.6 8.46 0.42 9.09e-16 Arsenic metabolism; CRC cis rs992157 0.798 rs7557709 chr2:219167529 G/A cg04880052 chr2:219191631 PNKD 0.42 6.72 0.35 8.09e-11 Colorectal cancer; CRC cis rs9814567 1.000 rs9813774 chr3:134227100 G/A cg06541857 chr3:134203789 ANAPC13;CEP63 -0.41 -6.22 -0.32 1.48e-9 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs7202877 0.561 rs9933956 chr16:75362813 T/C cg03315344 chr16:75512273 CHST6 0.49 5.93 0.31 7.78e-9 Type 2 diabetes;Type 1 diabetes; CRC cis rs2462686 0.965 rs1525831 chr7:45994409 C/T cg15898840 chr7:45960834 IGFBP3 0.38 5.96 0.31 6.44e-9 Major depressive disorder; CRC cis rs9467603 1.000 rs6940698 chr6:25821580 A/G cg08501292 chr6:25962987 TRIM38 -1.1 -9.11 -0.45 8.41e-18 Intelligence (multi-trait analysis); CRC cis rs6502050 0.749 rs7406163 chr17:80086389 C/T cg02741985 chr17:80059408 CCDC57 -0.44 -7.18 -0.37 4.75e-12 Life satisfaction; CRC cis rs9787249 0.957 rs12239844 chr1:40217258 T/C cg02773041 chr1:40204384 PPIE 0.62 9.25 0.45 2.9e-18 Blood protein levels; CRC cis rs7677751 0.806 rs7698425 chr4:55090656 C/T cg00691999 chr4:55094011 PDGFRA 0.44 6.34 0.33 7.43e-10 Corneal astigmatism; CRC cis rs728616 0.867 rs61860421 chr10:81743399 C/T cg05935833 chr10:81318306 SFTPA2 -0.76 -8.28 -0.42 3.12e-15 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs514406 0.621 rs1930306 chr1:53195686 C/G cg25767906 chr1:53392781 SCP2 0.42 6.62 0.34 1.48e-10 Monocyte count; CRC cis rs752010 0.871 rs2038976 chr1:42094498 A/G cg06885757 chr1:42089581 HIVEP3 0.52 8.98 0.44 2.11e-17 Lupus nephritis in systemic lupus erythematosus; CRC cis rs3924048 0.574 rs11121930 chr1:12616956 C/A cg23650765 chr1:12612165 NA 0.34 6.52 0.34 2.7e-10 Optic cup area; CRC cis rs35306767 0.807 rs34527494 chr10:935192 T/C cg20503657 chr10:835505 NA 1.22 14.71 0.63 5.29e-38 Eosinophil percentage of granulocytes; CRC cis rs8067545 1.000 rs9891739 chr17:19942177 C/T cg13482628 chr17:19912719 NA 0.54 8.52 0.43 5.69e-16 Schizophrenia; CRC cis rs62244186 0.659 rs12108134 chr3:44543030 A/G cg18165381 chr3:44552316 NA 0.37 5.66 0.3 3.27e-8 Depressive symptoms; CRC cis rs2404602 0.716 rs1125932 chr15:76820540 C/T cg03037974 chr15:76606532 NA 0.66 11.11 0.52 1.44e-24 Blood metabolite levels; CRC trans rs6500957 0.920 rs17648524 chr16:7459683 C/G cg26872475 chr11:119039430 NLRX1 0.42 6.22 0.32 1.5e-9 Spherical equivalent (joint analysis main effects and education interaction); CRC trans rs8073060 0.614 rs72829932 chr17:34055935 A/G cg19694781 chr19:47549865 TMEM160 1.08 14.7 0.63 5.8e-38 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; CRC cis rs6912958 0.559 rs242267 chr6:88061837 A/G cg04972856 chr6:88032051 C6orf162;GJB7 -0.31 -5.67 -0.3 3.07e-8 Monocyte percentage of white cells; CRC cis rs9322193 0.884 rs1108889 chr6:150166569 A/G cg13206674 chr6:150067644 NUP43 0.64 8.95 0.44 2.72e-17 Lung cancer; CRC cis rs56114371 0.777 rs200482 chr6:27773904 G/A cg26587870 chr6:27730563 NA -0.66 -6.84 -0.35 3.89e-11 Breast cancer; CRC cis rs2732480 0.500 rs2450989 chr12:48653408 A/G cg21466736 chr12:48725269 NA 0.52 7.88 0.4 4.92e-14 Hemoglobin concentration;Red blood cell count;Hematocrit; CRC cis rs9733 0.596 rs2867304 chr1:150630995 G/A cg17724175 chr1:150552817 MCL1 0.58 9.4 0.46 9.25e-19 Tonsillectomy; CRC trans rs4824093 0.610 rs77128035 chr22:50241024 C/T cg09872104 chr7:134855509 C7orf49 -0.82 -6.98 -0.36 1.68e-11 Amyotrophic lateral sclerosis (sporadic); CRC cis rs4713118 0.621 rs10484403 chr6:28033523 A/G cg15845792 chr6:28175446 NA 0.94 12.56 0.57 7.64e-30 Parkinson's disease; CRC cis rs847577 0.609 rs6465658 chr7:97816638 C/G cg24562669 chr7:97807699 LMTK2 0.79 17.53 0.7 4.58e-49 Breast cancer; CRC cis rs9463078 0.605 rs13215618 chr6:44936568 A/G cg25276700 chr6:44698697 NA 0.25 6.04 0.32 4.07e-9 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; CRC cis rs1008375 1.000 rs6848360 chr4:17634442 G/T cg04450456 chr4:17643702 FAM184B 0.36 5.69 0.3 2.82e-8 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs2197308 0.740 rs11182967 chr12:37935140 A/C cg26384229 chr12:38710491 ALG10B 0.68 8.97 0.44 2.37e-17 Morning vs. evening chronotype; CRC trans rs1367248 1.000 rs780038 chr2:125009945 A/T cg07402188 chr19:40720005 MAP3K10 -0.45 -6.2 -0.32 1.7e-9 Tonometry; CRC cis rs908922 0.651 rs1572534 chr1:152509689 G/A cg23254163 chr1:152506842 NA 0.45 8.64 0.43 2.51e-16 Hair morphology; CRC cis rs6502050 0.736 rs12150322 chr17:80061582 T/G cg02741985 chr17:80059408 CCDC57 -0.45 -7.25 -0.37 2.94e-12 Life satisfaction; CRC cis rs17384381 0.953 rs12139958 chr1:85842112 A/G cg16011679 chr1:85725395 C1orf52 0.63 6.45 0.33 4.05e-10 Lobe attachment (rater-scored or self-reported); CRC cis rs2976388 0.609 rs2585150 chr8:143792669 C/T cg24046110 chr8:143859143 LYNX1 0.49 8.61 0.43 3.15e-16 Urinary tract infection frequency; CRC cis rs875971 0.862 rs4718383 chr7:66108409 T/C cg12463550 chr7:65579703 CRCP -0.45 -5.95 -0.31 6.85e-9 Aortic root size; CRC cis rs3806843 1.000 rs10072015 chr5:140170655 A/T cg19875535 chr5:140030758 IK -0.59 -9.72 -0.47 8.7e-20 Depressive symptoms (multi-trait analysis); CRC cis rs6772849 0.930 rs4857914 chr3:128350684 C/T cg08795948 chr3:128337044 NA 0.34 5.77 0.3 1.83e-8 Monocyte percentage of white cells;Monocyte count; CRC cis rs2019137 0.560 rs7421852 chr2:113990261 G/A cg12889195 chr2:113992843 PAX8;LOC440839;LOC654433 0.64 9.63 0.47 1.73e-19 Lymphocyte counts; CRC cis rs644799 1.000 rs596277 chr11:95566886 G/A cg25622487 chr11:95524042 FAM76B;CEP57 0.77 11.99 0.55 9.91e-28 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs10504229 0.728 rs17804822 chr8:58156276 T/C cg11062466 chr8:58055876 NA 0.45 5.89 0.31 9.57e-9 Developmental language disorder (linguistic errors); CRC trans rs2727020 0.521 rs7107178 chr11:49526668 G/A cg15704280 chr7:45808275 SEPT13 0.76 9.99 0.48 1.08e-20 Coronary artery disease; CRC cis rs7845219 0.544 rs4735331 chr8:95917958 C/T cg16049864 chr8:95962084 TP53INP1 -0.44 -6.69 -0.35 9.62e-11 Type 2 diabetes; CRC cis rs11098499 0.754 rs12507565 chr4:120251121 G/A cg09307838 chr4:120376055 NA 0.61 9.59 0.47 2.22e-19 Corneal astigmatism; CRC cis rs2688608 0.592 rs2306328 chr10:75579510 C/T cg16540259 chr10:75572220 NDST2 0.38 6.29 0.33 1.02e-9 Inflammatory bowel disease; CRC cis rs7772486 0.727 rs6941429 chr6:145952283 G/A cg23711669 chr6:146136114 FBXO30 0.76 12.79 0.58 1.09e-30 Lobe attachment (rater-scored or self-reported); CRC cis rs7786877 0.500 rs2272572 chr7:100285888 C/T cg00334542 chr7:100209784 MOSPD3 -0.54 -6.84 -0.35 3.78e-11 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs8105895 0.935 rs2163835 chr19:22242679 C/T cg02657401 chr19:22469223 NA -0.34 -5.65 -0.3 3.56e-8 Body mass index (change over time); CRC cis rs9372498 0.536 rs62424199 chr6:118827252 G/A cg18833306 chr6:118973337 C6orf204 0.45 5.85 0.31 1.2e-8 Diastolic blood pressure; CRC cis rs7618915 0.524 rs35249778 chr3:52661640 G/C cg07507251 chr3:52567010 NT5DC2 0.42 6.13 0.32 2.54e-9 Bipolar disorder; CRC cis rs66731853 0.769 rs657624 chr1:20888348 C/T cg04087271 chr1:20915334 CDA -0.32 -5.67 -0.3 3.16e-8 Mean corpuscular volume; CRC cis rs2576037 0.526 rs9962523 chr18:44486414 A/T cg19077165 chr18:44547161 KATNAL2 -0.58 -9.54 -0.47 3.32e-19 Personality dimensions; CRC cis rs367943 1.000 rs348956 chr5:112821464 C/T cg12552261 chr5:112820674 MCC 0.49 7.59 0.39 3.23e-13 Type 2 diabetes; CRC cis rs425277 0.606 rs12082939 chr1:2078922 C/T cg12639453 chr1:2035780 PRKCZ 0.34 6.7 0.35 8.83e-11 Height; CRC cis rs7809950 0.817 rs2222845 chr7:107281829 C/T cg23024343 chr7:107201750 COG5 0.73 9.81 0.48 4.12e-20 Coronary artery disease; CRC cis rs9435341 0.965 rs1730859 chr1:107617707 A/G cg11070056 chr1:107600091 PRMT6 0.4 5.76 0.3 1.93e-8 Facial morphology (factor 21, depth of nasal alae); CRC cis rs1572438 0.811 rs6916731 chr6:880428 G/C cg13447295 chr6:887704 NA 0.55 8.39 0.42 1.48e-15 Aging; CRC cis rs2836950 0.565 rs2836931 chr21:40546569 T/G cg11644478 chr21:40555479 PSMG1 -0.52 -7.87 -0.4 5.16e-14 Menarche (age at onset); CRC cis rs9467711 0.559 rs2295593 chr6:26501768 C/T cg12315302 chr6:26189340 HIST1H4D 0.75 6.27 0.33 1.13e-9 Autism spectrum disorder or schizophrenia; CRC cis rs968567 0.705 rs174572 chr11:61598288 C/T cg00603274 chr11:61596626 FADS2 -0.56 -7.54 -0.38 4.73e-13 Blood metabolite levels;Rheumatoid arthritis;Vitiligo;Glycerophospholipid levels; CRC cis rs9902453 0.933 rs7221154 chr17:28505024 A/G cg26525008 chr17:28256777 EFCAB5;SSH2 -0.61 -9.54 -0.47 3.41e-19 Coffee consumption (cups per day); CRC cis rs6684514 1.000 rs3806407 chr1:156251742 T/C cg16558208 chr1:156270281 VHLL 0.58 9.08 0.45 1.03e-17 Mean corpuscular hemoglobin concentration;Glycated hemoglobin levels; CRC cis rs155076 0.625 rs4769159 chr13:21881978 A/C cg21970626 chr13:21893289 NA -0.44 -6.59 -0.34 1.8e-10 White matter hyperintensity burden; CRC cis rs11690935 0.550 rs6746701 chr2:172869255 G/A cg13550731 chr2:172543902 DYNC1I2 0.62 8.89 0.44 3.98e-17 Schizophrenia; CRC cis rs3087591 0.708 rs7350943 chr17:29684553 C/T cg24425628 chr17:29625626 OMG;NF1 0.72 13.1 0.59 7.5e-32 Hip circumference; CRC cis rs6582630 0.513 rs11181246 chr12:38302670 C/T cg13010199 chr12:38710504 ALG10B 0.47 6.29 0.33 1.01e-9 Drug-induced liver injury (flucloxacillin); CRC cis rs10504229 0.517 rs75486476 chr8:58056079 G/T cg08280861 chr8:58055591 NA 0.44 6.25 0.33 1.24e-9 Developmental language disorder (linguistic errors); CRC cis rs9467773 0.620 rs2451744 chr6:26633463 G/T cg09904177 chr6:26538194 HMGN4 0.72 11.39 0.53 1.42e-25 Intelligence (multi-trait analysis); CRC cis rs12541335 0.639 rs6993855 chr8:22163797 A/G cg18135555 chr8:22132992 PIWIL2 0.4 7.92 0.4 3.72e-14 Hypertriglyceridemia; CRC cis rs6500395 1.000 rs904819 chr16:48622583 C/A cg04672837 chr16:48644449 N4BP1 0.44 6.6 0.34 1.69e-10 Response to tocilizumab in rheumatoid arthritis; CRC trans rs1455244 0.700 rs7229302 chr18:11508904 G/T cg24796471 chr19:6737389 GPR108 0.42 6.5 0.34 3.06e-10 Schizophrenia; CRC cis rs12497850 0.864 rs3212 chr3:49145741 T/C cg20833759 chr3:49053208 WDR6;DALRD3 0.5 8.1 0.41 1.06e-14 Parkinson's disease; CRC cis rs6662572 0.737 rs72677533 chr1:46536558 T/C cg03123370 chr1:45965343 CCDC163P;MMACHC 0.49 6.33 0.33 7.85e-10 Blood protein levels; CRC cis rs514406 0.758 rs532242 chr1:53308665 C/G cg27535305 chr1:53392650 SCP2 -0.38 -6.9 -0.36 2.72e-11 Monocyte count; CRC cis rs7617773 0.925 rs7374376 chr3:48172687 T/C cg11946769 chr3:48343235 NME6 -0.45 -6.3 -0.33 9.28e-10 Coronary artery disease; CRC trans rs9650657 0.655 rs4841434 chr8:10586123 T/C cg06636001 chr8:8085503 FLJ10661 -0.47 -6.51 -0.34 2.78e-10 Neuroticism; CRC cis rs2645694 0.626 rs904050 chr4:77826089 T/G cg10057126 chr4:77819792 ANKRD56 0.35 5.9 0.31 9.2e-9 Emphysema distribution in smoking; CRC cis rs1983170 1.000 rs1983170 chr1:91986482 G/A cg21854759 chr1:92012499 NA 0.51 6.48 0.34 3.28e-10 Eosinophil percentage of white cells; CRC trans rs10506458 1.000 rs73128779 chr12:63441852 T/G cg22491629 chr6:157744540 C6orf35 -0.72 -8.71 -0.43 1.54e-16 Hemostatic factors and hematological phenotypes; CRC trans rs8073060 0.586 rs225292 chr17:33926383 G/A cg19694781 chr19:47549865 TMEM160 -0.81 -11.26 -0.53 4.44e-25 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; CRC cis rs1568889 0.775 rs35243076 chr11:28250618 G/A cg06544937 chr11:28130018 METT5D1;KIF18A 0.91 15.13 0.64 1.32e-39 Bipolar disorder; CRC cis rs10888329 0.707 rs6587437 chr1:248355867 T/G cg00666640 chr1:248458726 OR2T12 0.44 6.97 0.36 1.75e-11 Autism spectrum disorder; CRC cis rs861020 0.771 rs126280 chr1:210019824 A/G cg09163369 chr1:210001066 C1orf107 0.59 8.01 0.4 2e-14 Orofacial clefts; CRC cis rs736801 0.964 rs17622656 chr5:131820997 A/G cg21138405 chr5:131827807 IRF1 0.36 5.99 0.31 5.55e-9 Breast cancer;Mosquito bite size; CRC cis rs11098499 0.722 rs17595727 chr4:120262074 C/T cg24375607 chr4:120327624 NA -0.47 -7.68 -0.39 1.84e-13 Corneal astigmatism; CRC cis rs55823223 0.590 rs11870142 chr17:73859002 A/G cg08125733 chr17:73851984 WBP2 0.72 9.09 0.45 9.41e-18 Psoriasis; CRC cis rs4819052 0.851 rs4819049 chr21:46673086 C/G cg19498844 chr21:46707878 POFUT2;LOC642852 0.77 11.17 0.52 9.19e-25 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC trans rs2228479 0.618 rs17233623 chr16:89811209 C/T cg24644049 chr4:85504048 CDS1 0.77 6.8 0.35 5.05e-11 Skin colour saturation; CRC cis rs877282 0.945 rs10904550 chr10:774177 C/T cg17470449 chr10:769945 NA 0.63 9.17 0.45 5.1e-18 Uric acid levels; CRC cis rs4654899 0.525 rs12035087 chr1:21471606 T/A cg02927042 chr1:21476669 EIF4G3 0.4 6.45 0.34 3.98e-10 Superior frontal gyrus grey matter volume; CRC trans rs9326248 0.954 rs521171 chr11:117064693 C/G cg18755114 chr2:209119030 IDH1 -0.4 -6.11 -0.32 2.87e-9 Blood protein levels; CRC cis rs4638749 0.773 rs4676190 chr2:108858619 A/G cg06795125 chr2:108905320 SULT1C2 -0.38 -5.8 -0.3 1.55e-8 Blood pressure; CRC cis rs736408 0.812 rs2270197 chr3:52824095 T/G cg10802521 chr3:52805072 NEK4 -0.52 -7.07 -0.36 9.17e-12 Bipolar disorder; CRC cis rs853679 0.517 rs9348793 chr6:28084189 G/A cg25164649 chr6:28176230 NA 0.77 9.5 0.46 4.6e-19 Depression; CRC cis rs35883536 0.935 rs3904674 chr1:101138932 C/T cg14515779 chr1:101123966 NA -0.41 -7.97 -0.4 2.69e-14 Monocyte count; CRC cis rs798554 0.683 rs1636264 chr7:2864586 G/T cg04166393 chr7:2884313 GNA12 0.5 7.17 0.37 4.86e-12 Height; CRC cis rs6764363 0.527 rs62228321 chr3:279372 A/C cg02057681 chr3:285234 CHL1 0.43 7.31 0.37 2.07e-12 Sudden cardiac arrest; CRC cis rs6547741 0.967 rs4665999 chr2:27834444 T/C cg27432699 chr2:27873401 GPN1 0.77 13.85 0.61 1.14e-34 Oral cavity cancer; CRC trans rs1455244 0.700 rs7229302 chr18:11508904 G/T cg01532600 chr16:285188 ITFG3 0.42 6.06 0.32 3.79e-9 Schizophrenia; CRC cis rs2066819 1.000 rs75265219 chr12:56640341 G/A cg26714650 chr12:56694279 CS -1.41 -11.64 -0.54 1.88e-26 Psoriasis vulgaris; CRC cis rs990171 1.000 rs1807782 chr2:103033147 C/T cg03938978 chr2:103052716 IL18RAP 0.46 5.82 0.31 1.4e-8 Lymphocyte counts; CRC cis rs17213078 0.602 rs4851113 chr2:106747009 G/C cg15412446 chr2:106886593 NA 0.4 6.37 0.33 6.26e-10 Facial morphology (factor 23); CRC cis rs6963495 0.818 rs6957192 chr7:105150255 A/C cg13798780 chr7:105162888 PUS7 -0.67 -8.46 -0.42 8.85e-16 Bipolar disorder (body mass index interaction); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg10815165 chr10:105212270 CALHM2 0.34 6.06 0.32 3.64e-9 Liver disease severity in Alagille syndrome; CRC cis rs6912958 0.678 rs9450733 chr6:88250081 C/T cg08069147 chr6:88032118 GJB7;C6orf162 -0.56 -8.43 -0.42 1.12e-15 Monocyte percentage of white cells; CRC cis rs10504229 0.679 rs17193048 chr8:58055392 G/A cg24829409 chr8:58192753 C8orf71 -0.64 -7.96 -0.4 2.9e-14 Developmental language disorder (linguistic errors); CRC cis rs780096 0.565 rs780104 chr2:27677691 G/A cg12648201 chr2:27665141 KRTCAP3 -0.31 -6.28 -0.33 1.05e-9 Total body bone mineral density; CRC cis rs2749592 0.550 rs4934881 chr10:37914346 A/C cg25517755 chr10:38738941 LOC399744 0.41 5.86 0.31 1.13e-8 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs12760731 0.720 rs16852717 chr1:178309723 T/C cg00404053 chr1:178313656 RASAL2 0.92 9.63 0.47 1.74e-19 Obesity-related traits; CRC cis rs875971 0.545 rs11766183 chr7:65839160 G/C cg03233332 chr7:66118400 NA -0.43 -5.87 -0.31 1.05e-8 Aortic root size; CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg18565132 chr8:103613344 NA 0.36 6.04 0.32 4.22e-9 Obesity-related traits; CRC cis rs911186 0.509 rs6934329 chr6:27158033 A/G cg12292205 chr6:26970375 C6orf41 -0.78 -8.36 -0.42 1.81e-15 Autism spectrum disorder or schizophrenia; CRC cis rs1448094 0.512 rs56082822 chr12:86255475 C/T cg02569458 chr12:86230093 RASSF9 0.43 7.37 0.38 1.35e-12 Major depressive disorder; CRC cis rs2075371 0.829 rs9641970 chr7:134004887 C/A cg11752832 chr7:134001865 SLC35B4 0.44 6.58 0.34 1.81e-10 Mean platelet volume; CRC cis rs7937682 0.847 rs11213948 chr11:111464401 G/A cg09085632 chr11:111637200 PPP2R1B -0.94 -17.74 -0.7 7.01e-50 Primary sclerosing cholangitis; CRC cis rs10504229 0.728 rs72650852 chr8:58150463 G/A cg11062466 chr8:58055876 NA 0.48 6.17 0.32 2.04e-9 Developmental language disorder (linguistic errors); CRC cis rs5753618 0.583 rs7293171 chr22:31802324 T/C cg07713946 chr22:31675144 LIMK2 0.43 6.3 0.33 9.29e-10 Colorectal cancer; CRC cis rs9322193 0.923 rs1934534 chr6:150033032 A/G cg00933542 chr6:150070202 PCMT1 0.32 6.64 0.34 1.32e-10 Lung cancer; CRC cis rs847577 0.722 rs6951277 chr7:97711783 A/G cg00277769 chr7:97922759 BAIAP2L1 -0.42 -7.04 -0.36 1.12e-11 Breast cancer; CRC trans rs1005277 0.579 rs2472176 chr10:38382921 T/C cg23533926 chr12:111358616 MYL2 -0.52 -7.85 -0.4 6.11e-14 Extrinsic epigenetic age acceleration; CRC trans rs2303319 0.504 rs55925603 chr2:162497210 G/A cg10272801 chr16:14013773 ERCC4 -0.67 -6.07 -0.32 3.6e-9 Cognitive function; CRC cis rs17209837 0.607 rs2109505 chr7:87079406 T/A cg00919237 chr7:87102261 ABCB4 -0.51 -6.64 -0.34 1.3100000000000001e-10 Gallbladder cancer; CRC cis rs66887589 0.807 rs9799664 chr4:120326678 C/T cg09307838 chr4:120376055 NA 0.54 8.29 0.42 2.95e-15 Diastolic blood pressure; CRC cis rs2070677 0.935 rs4335491 chr10:135422460 T/G cg16964102 chr10:135390573 NA 0.49 6.77 0.35 5.9e-11 Gout; CRC cis rs3213545 0.659 rs2259693 chr12:121457995 G/A cg02403541 chr12:121454288 C12orf43 0.46 7.37 0.38 1.4e-12 Subjective well-being;Cardiovascular disease risk factors; CRC cis rs3796352 1.000 rs61172708 chr3:52996052 T/G cg27565382 chr3:53032988 SFMBT1 0.7 6.19 0.32 1.76e-9 Immune reponse to smallpox (secreted IL-2); CRC trans rs10802346 0.545 rs1361408 chr1:246410054 T/G cg13514129 chr1:39547527 MACF1 0.68 10.8 0.51 1.73e-23 Fractional exhaled nitric oxide (childhood); CRC cis rs9911578 1.000 rs12936058 chr17:57017420 T/C cg12560992 chr17:57184187 TRIM37 0.92 17.22 0.69 8.3e-48 Intelligence (multi-trait analysis); CRC cis rs1552244 0.810 rs35711405 chr3:10116939 C/T cg16606324 chr3:10149918 C3orf24 0.72 9.82 0.48 3.92e-20 Alzheimer's disease; CRC cis rs1971762 0.545 rs6580949 chr12:53924293 T/C cg06632207 chr12:54070931 ATP5G2 0.45 7.53 0.38 4.91e-13 Height; CRC trans rs7618501 1.000 rs6775384 chr3:49853073 G/A cg21659725 chr3:3221576 CRBN 0.85 15.84 0.66 2.12e-42 Intelligence (multi-trait analysis); CRC cis rs2836974 0.932 rs2234543 chr21:40572072 G/A cg17971929 chr21:40555470 PSMG1 0.83 11.94 0.55 1.5e-27 Cognitive function; CRC cis rs727505 0.865 rs17325193 chr7:124648385 A/G cg23710748 chr7:124431027 NA -0.81 -14.1 -0.61 1.26e-35 Lewy body disease; CRC cis rs7615952 0.576 rs4646759 chr3:125822946 G/C cg18479299 chr3:125709523 NA -0.55 -6.59 -0.34 1.75e-10 Blood pressure (smoking interaction); CRC cis rs10504229 0.683 rs56235637 chr8:58106008 T/C cg02725872 chr8:58115012 NA -0.66 -11.36 -0.53 1.85e-25 Developmental language disorder (linguistic errors); CRC cis rs7580658 0.550 rs62160290 chr2:128200695 C/T cg09760422 chr2:128146352 NA -0.31 -5.68 -0.3 2.98e-8 Protein C levels; CRC cis rs2573652 1.000 rs2573651 chr15:100514109 T/G cg00587665 chr15:100533223 ADAMTS17 -0.36 -6.06 -0.32 3.82e-9 Height; CRC cis rs977987 0.806 rs11642572 chr16:75452782 C/T cg03315344 chr16:75512273 CHST6 0.54 9.08 0.45 1.04e-17 Dupuytren's disease; CRC cis rs17270561 0.608 rs9358875 chr6:25738008 G/A cg16482183 chr6:26056742 HIST1H1C 0.83 10.62 0.51 7.43e-23 Iron status biomarkers; CRC cis rs870825 0.616 rs10022834 chr4:185649431 A/G cg04058563 chr4:185651563 MLF1IP 0.72 9.3 0.46 2.04e-18 Blood protein levels; CRC cis rs12760731 0.565 rs16828608 chr1:178129899 C/T cg00404053 chr1:178313656 RASAL2 0.76 8.6 0.43 3.34e-16 Obesity-related traits; CRC cis rs10089 1.000 rs4836361 chr5:127459991 T/C cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.72 9.97 0.48 1.28e-20 Ileal carcinoids; CRC cis rs929596 0.517 rs1875263 chr2:234625622 C/T cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.57 -8.72 -0.43 1.37e-16 Total bilirubin levels in HIV-1 infection; CRC cis rs910316 0.967 rs4384542 chr14:75658013 A/C cg03030879 chr14:75389066 RPS6KL1 0.43 6.64 0.34 1.29e-10 Height; CRC cis rs35110281 0.592 rs6417729 chr21:44967202 A/C cg04455712 chr21:45112962 RRP1B 0.41 7.77 0.39 1.03e-13 Mean corpuscular volume; CRC cis rs17401966 1.000 rs58549151 chr1:10314657 A/C cg19773385 chr1:10388646 KIF1B -0.58 -8.04 -0.41 1.58e-14 Hepatocellular carcinoma; CRC cis rs1691799 0.867 rs1168356 chr12:66750469 A/G cg16791601 chr12:66731901 HELB -0.69 -11.63 -0.54 1.98e-26 White blood cell count (basophil); CRC cis rs7662987 0.517 rs2602878 chr4:100039953 T/G cg13256891 chr4:100009986 ADH5 0.62 8.37 0.42 1.64e-15 Smoking initiation; CRC cis rs1799949 1.000 rs11657835 chr17:41291953 C/G cg25072359 chr17:41440525 NA 0.44 6.42 0.33 4.86e-10 Menopause (age at onset); CRC cis rs807669 0.903 rs762527 chr22:19183470 A/G cg02655711 chr22:19163373 SLC25A1 0.98 19.99 0.74 9.58e-59 Metabolite levels; CRC cis rs6502050 0.835 rs4789738 chr17:80123053 G/A cg02741985 chr17:80059408 CCDC57 0.43 7.15 0.37 5.59e-12 Life satisfaction; CRC cis rs12950390 0.853 rs11079791 chr17:45859099 C/T cg24803719 chr17:45855879 NA -0.3 -6.43 -0.33 4.47e-10 IgG glycosylation; CRC cis rs9925964 0.748 rs11640961 chr16:30979818 C/T cg03418659 chr16:31128414 MYST1 0.42 6.12 0.32 2.71e-9 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs1862618 0.671 rs2591968 chr5:56233541 A/G cg03609598 chr5:56110824 MAP3K1 -0.59 -7.83 -0.4 6.55e-14 Initial pursuit acceleration; CRC cis rs6951245 1.000 rs28399710 chr7:1070631 G/T cg26224354 chr7:1096374 C7orf50;GPR146 -0.88 -11.08 -0.52 1.89e-24 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs4555082 0.874 rs3000075 chr14:105713219 C/T cg13114125 chr14:105738426 BRF1 0.76 11.4 0.53 1.33e-25 Mean platelet volume;Platelet distribution width; CRC cis rs10504229 0.953 rs67677367 chr8:58175264 T/G cg22535103 chr8:58192502 C8orf71 -0.82 -12.27 -0.56 9.63e-29 Developmental language disorder (linguistic errors); CRC cis rs9583531 0.689 rs9515273 chr13:111383427 G/C cg24331049 chr13:111365604 ING1 0.56 7.32 0.37 1.88e-12 Coronary artery disease; CRC cis rs10504229 0.683 rs16921810 chr8:58106067 A/G cg02725872 chr8:58115012 NA -0.66 -11.36 -0.53 1.85e-25 Developmental language disorder (linguistic errors); CRC cis rs72781680 0.678 rs2551341 chr2:24014778 G/T cg08917208 chr2:24149416 ATAD2B 0.52 6.12 0.32 2.72e-9 Lymphocyte counts; CRC trans rs6076960 0.682 rs6054065 chr20:6267920 G/A cg21095983 chr6:86352623 SYNCRIP 0.5 7.1 0.36 7.82e-12 Smooth-surface caries; CRC cis rs1552244 0.554 rs7638846 chr3:10048601 A/G cg13047869 chr3:10149882 C3orf24 0.39 5.92 0.31 8.16e-9 Alzheimer's disease; CRC cis rs3760982 0.813 rs10426528 chr19:44299298 A/G cg12072164 chr19:44306565 LYPD5 0.38 6.08 0.32 3.25e-9 Breast cancer (estrogen-receptor negative);Breast cancer; CRC cis rs854765 0.547 rs9896837 chr17:17924868 A/G cg04398451 chr17:18023971 MYO15A -0.58 -10.59 -0.5 9.83e-23 Total body bone mineral density; CRC cis rs9359856 0.510 rs2768936 chr6:90441851 A/G cg13799429 chr6:90582589 CASP8AP2 -0.77 -10.03 -0.48 7.73e-21 Bipolar disorder; CRC cis rs6860806 0.661 rs2171247 chr5:131580234 G/T cg18758796 chr5:131593413 PDLIM4 0.43 7.92 0.4 3.66e-14 Breast cancer; CRC cis rs12760731 0.920 rs12750502 chr1:178487224 G/A cg00404053 chr1:178313656 RASAL2 0.6 7.0 0.36 1.41e-11 Obesity-related traits; CRC cis rs10779751 0.762 rs6540965 chr1:11325521 C/G cg08854313 chr1:11322531 MTOR -0.46 -6.52 -0.34 2.61e-10 Body mass index; CRC cis rs9462027 0.540 rs9469867 chr6:34742449 C/T cg07306190 chr6:34760872 UHRF1BP1 -0.35 -6.25 -0.33 1.28e-9 Systemic lupus erythematosus; CRC cis rs6500602 0.627 rs934929 chr16:4587789 A/G cg08645402 chr16:4508243 NA -0.59 -9.67 -0.47 1.25e-19 Schizophrenia; CRC cis rs13064411 0.542 rs4396864 chr3:113212562 C/T cg18753928 chr3:113234510 CCDC52 -0.53 -8.2 -0.41 5.32e-15 Response to simvastatin treatment (PCSK9 protein level change); CRC cis rs7172809 0.643 rs16953967 chr15:77836521 C/T cg10437265 chr15:77819839 NA -0.37 -6.12 -0.32 2.66e-9 Glucose homeostasis traits; CRC cis rs9648716 0.608 rs1267610 chr7:140525883 C/T cg10747023 chr7:140774559 NA 0.45 6.2 0.32 1.71e-9 Type 2 diabetes; CRC cis rs853679 0.517 rs1340004 chr6:28103691 C/T cg12273811 chr6:28175739 NA 0.72 9.13 0.45 7.05e-18 Depression; CRC cis rs7737355 0.812 rs31241 chr5:130808198 T/C cg25547332 chr5:131281432 NA 0.35 5.6 0.3 4.52e-8 Life satisfaction; CRC cis rs425277 0.583 rs4648807 chr1:2040898 A/G cg19257562 chr1:2043853 PRKCZ 0.38 6.34 0.33 7.69e-10 Height; CRC cis rs713477 0.967 rs4898865 chr14:55910998 G/A cg13175173 chr14:55914753 NA -0.52 -9.85 -0.48 3.19e-20 Pediatric bone mineral content (femoral neck); CRC cis rs2243480 1.000 rs13237037 chr7:65997882 T/C cg18252515 chr7:66147081 NA -1.29 -15.43 -0.65 8.74e-41 Diabetic kidney disease; CRC cis rs6424115 1.000 rs1018396 chr1:24133612 G/A cg10978503 chr1:24200527 CNR2 0.47 8.53 0.43 5.41e-16 Immature fraction of reticulocytes; CRC cis rs6952808 0.609 rs10274300 chr7:1950405 C/G cg14004847 chr7:1930337 MAD1L1 -0.41 -6.0 -0.31 5.12e-9 Bipolar disorder and schizophrenia; CRC cis rs60871478 1.000 rs62432860 chr7:807522 G/C cg13844804 chr7:814759 HEATR2 0.65 8.51 0.42 6.2e-16 Cerebrospinal P-tau181p levels; CRC cis rs2290405 0.527 rs4690329 chr4:931385 T/A cg04045327 chr4:905805 GAK -0.41 -6.68 -0.35 1.02e-10 Systemic sclerosis; CRC trans rs1814175 0.935 rs11040465 chr11:49689323 C/T cg11707556 chr5:10655725 ANKRD33B -0.44 -8.11 -0.41 1.01e-14 Height; CRC cis rs3617 0.625 rs3774364 chr3:52863605 G/A cg11645453 chr3:52864694 ITIH4 0.37 6.65 0.34 1.19e-10 Red blood cell count;Autism spectrum disorder or schizophrenia; CRC cis rs1018836 0.923 rs13268594 chr8:91588545 G/T cg16814680 chr8:91681699 NA -0.74 -11.74 -0.54 7.91e-27 Ejection fraction in Tripanosoma cruzi seropositivity; CRC cis rs9859260 0.744 rs406271 chr3:195776976 T/C cg12923728 chr3:195709715 SDHAP1 0.48 6.54 0.34 2.35e-10 Mean corpuscular volume; CRC cis rs9311474 0.581 rs4687626 chr3:52569098 G/A cg18099408 chr3:52552593 STAB1 -0.52 -9.2 -0.45 4.13e-18 Electroencephalogram traits; CRC cis rs561341 0.941 rs736678 chr17:30347423 G/T cg00745463 chr17:30367425 LRRC37B -0.83 -9.13 -0.45 7.21e-18 Hip circumference adjusted for BMI; CRC cis rs2836974 0.644 rs9978775 chr21:40694526 A/G cg11890956 chr21:40555474 PSMG1 -0.82 -12.65 -0.57 3.74e-30 Cognitive function; CRC cis rs9287719 0.967 rs2287061 chr2:10743153 C/T cg00105475 chr2:10696890 NA 0.45 7.3 0.37 2.19e-12 Prostate cancer; CRC trans rs1364477 0.529 rs7575327 chr2:186181992 A/G cg12230250 chr22:40042864 CACNA1I -0.29 -6.12 -0.32 2.69e-9 IgG glycosylation; CRC cis rs72730918 0.590 rs1378895 chr15:51937295 G/A cg14296394 chr15:51910925 DMXL2 -0.47 -6.32 -0.33 8.69e-10 Intelligence (multi-trait analysis); CRC cis rs7909074 0.966 rs4948645 chr10:45391481 A/G cg04218760 chr10:45406644 TMEM72 -0.32 -8.72 -0.43 1.41e-16 Mean corpuscular volume; CRC cis rs172166 0.637 rs1225597 chr6:28162087 C/T cg12273811 chr6:28175739 NA 0.66 10.07 0.49 5.57e-21 Cardiac Troponin-T levels; CRC cis rs4474465 1.000 rs10899521 chr11:78184560 T/A cg27205649 chr11:78285834 NARS2 -0.46 -5.73 -0.3 2.24e-8 Alzheimer's disease (survival time); CRC cis rs4285028 0.747 rs7647351 chr3:121422109 T/C cg20356878 chr3:121714668 ILDR1 -0.42 -6.01 -0.31 5.02e-9 Multiple sclerosis; CRC cis rs1395 0.744 rs11126932 chr2:27476282 G/A cg23587288 chr2:27483067 SLC30A3 -0.4 -6.74 -0.35 7.29e-11 Blood metabolite levels; CRC cis rs2929278 0.561 rs2927071 chr15:43919081 T/C cg02155558 chr15:43621948 ADAL;LCMT2 0.43 5.8 0.3 1.52e-8 Schizophrenia; CRC cis rs6964587 1.000 rs2157747 chr7:91750578 A/G cg17063962 chr7:91808500 NA 0.82 14.48 0.62 4.37e-37 Breast cancer; CRC trans rs2727020 0.894 rs10839265 chr11:49369733 C/T cg03929089 chr4:120376271 NA -0.72 -9.64 -0.47 1.55e-19 Coronary artery disease; CRC cis rs17065868 0.764 rs9533854 chr13:45021880 A/T cg10246903 chr13:45222710 NA 0.6 6.56 0.34 2.07e-10 Antineutrophil cytoplasmic antibody-associated vasculitis; CRC cis rs28655083 0.956 rs11863953 chr16:77065710 G/A cg01753188 chr16:77233325 SYCE1L;MON1B -0.57 -8.09 -0.41 1.14e-14 Lobe attachment (rater-scored or self-reported); CRC cis rs7493 1.000 rs2068604 chr7:95041542 G/T cg07404485 chr7:94953653 PON1 -0.45 -5.91 -0.31 8.36e-9 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs2732480 0.577 rs2732448 chr12:48730600 T/C cg04545296 chr12:48745243 ZNF641 0.36 6.15 0.32 2.19e-9 Hemoglobin concentration;Red blood cell count;Hematocrit; CRC cis rs9611565 0.921 rs6002333 chr22:41719469 C/T cg03806693 chr22:41940476 POLR3H -0.83 -10.9 -0.51 8.14e-24 Vitiligo; CRC cis rs7385804 0.761 rs1734910 chr7:100309544 A/G cg20848291 chr7:100343083 ZAN 0.49 7.61 0.39 2.95e-13 Iron status biomarkers;Mean corpuscular hemoglobin;Hematocrit;Iron status biomarkers (transferrin saturation);Red blood cell count;Iron status biomarkers (iron levels);Mean corpuscular volume;Hematological parameters; CRC cis rs9527 0.590 rs34104646 chr10:104896078 T/A cg15744005 chr10:104629667 AS3MT -0.31 -6.1 -0.32 3.03e-9 Arsenic metabolism; CRC cis rs2576037 0.623 rs2576040 chr18:44582027 A/G cg20875182 chr18:44561130 TCEB3B;KATNAL2 -0.6 -10.33 -0.49 7.38e-22 Personality dimensions; CRC trans rs2303319 0.504 rs62189054 chr2:162624654 C/G cg22677401 chr17:46026860 NA -0.67 -6.09 -0.32 3.14e-9 Cognitive function; CRC trans rs11098499 0.863 rs34868248 chr4:120442430 A/G cg25214090 chr10:38739885 LOC399744 0.64 9.94 0.48 1.61e-20 Corneal astigmatism; CRC cis rs6062302 0.522 rs2236503 chr20:62224595 G/A cg06363034 chr20:62225388 GMEB2 -0.45 -6.88 -0.35 2.94e-11 Glioblastoma; CRC cis rs9814567 1.000 rs2370641 chr3:134222161 A/C cg06109529 chr3:134205091 CEP63;ANAPC13 -0.81 -12.26 -0.56 1e-28 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs58804349 0.685 rs9422448 chr10:43288816 A/G cg20628663 chr10:43360327 NA 0.72 7.32 0.37 1.93e-12 Pediatric bone mineral content (radius); CRC cis rs72627123 0.867 rs8015927 chr14:74465756 A/T cg12022184 chr14:74485813 ENTPD5;C14orf45 -0.71 -5.8 -0.3 1.52e-8 Morning vs. evening chronotype; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg06608945 chr2:219082296 ARPC2 0.44 6.33 0.33 8.13e-10 Intelligence (multi-trait analysis); CRC cis rs13108904 0.557 rs1250086 chr4:1248051 G/A cg24560729 chr4:1342394 KIAA1530 -0.34 -5.62 -0.3 4.12e-8 Obesity-related traits; CRC cis rs9611565 0.921 rs5751081 chr22:41742788 A/T cg03806693 chr22:41940476 POLR3H -0.66 -9.63 -0.47 1.63e-19 Vitiligo; CRC cis rs13191362 1.000 rs13190742 chr6:163008758 G/A cg23758597 chr6:163146217 PARK2 -0.55 -6.12 -0.32 2.7e-9 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs7827545 1.000 rs6578238 chr8:135569490 A/C cg07299736 chr8:135490787 ZFAT -0.37 -6.48 -0.34 3.41e-10 Hypertension (SNP x SNP interaction); CRC cis rs6866344 0.697 rs62392833 chr5:178135452 T/A cg10224037 chr5:178157518 ZNF354A 0.78 10.87 0.51 1.03e-23 Neutrophil percentage of white cells; CRC cis rs9660180 0.967 rs2272908 chr1:1721479 A/G cg13866156 chr1:1669148 SLC35E2 0.6 9.42 0.46 8.2e-19 Body mass index; CRC cis rs780096 0.526 rs4803 chr2:27667297 A/G cg12000995 chr2:27665139 KRTCAP3 -0.32 -6.75 -0.35 6.69e-11 Total body bone mineral density; CRC cis rs11711311 1.000 rs9879760 chr3:113457948 G/A cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.51 -6.84 -0.35 3.88e-11 IgG glycosylation; CRC cis rs909002 0.772 rs7525618 chr1:32073766 C/T cg01639898 chr1:32083012 HCRTR1 0.3 6.1 0.32 3e-9 Intelligence (multi-trait analysis); CRC cis rs10791323 0.627 rs2723614 chr11:133705871 T/G cg00579200 chr11:133705235 NA -0.41 -5.92 -0.31 7.91e-9 Childhood ear infection; CRC cis rs6456156 0.904 rs2021033 chr6:167524239 C/T cg07741184 chr6:167504864 NA -0.34 -5.67 -0.3 3.07e-8 Primary biliary cholangitis; CRC cis rs12900413 0.687 rs28475471 chr15:90311749 C/T cg24249390 chr15:90295951 MESP1 -0.58 -9.28 -0.46 2.4e-18 Coronary artery aneurysm in Kawasaki disease; CRC cis rs6500602 0.701 rs6500614 chr16:4573938 A/G cg08645402 chr16:4508243 NA 0.58 8.78 0.44 9.02e-17 Schizophrenia; CRC cis rs9894429 0.789 rs7502346 chr17:79603741 T/C cg21028142 chr17:79581711 NPLOC4 0.32 6.8 0.35 5.02e-11 Eye color traits; CRC cis rs1577917 1.000 rs10944170 chr6:86685469 A/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.52 -6.8 -0.35 5.06e-11 Response to antipsychotic treatment; CRC cis rs7918232 0.882 rs788237 chr10:27457932 C/T cg14240646 chr10:27532245 ACBD5 0.82 9.22 0.45 3.69e-18 Breast cancer; CRC cis rs2404602 0.692 rs1838048 chr15:76931679 A/G cg22467129 chr15:76604101 ETFA -0.38 -6.37 -0.33 6.46e-10 Blood metabolite levels; CRC cis rs9467773 1.000 rs9467787 chr6:26556769 G/T cg09904177 chr6:26538194 HMGN4 0.85 14.85 0.63 1.61e-38 Intelligence (multi-trait analysis); CRC cis rs7572644 0.564 rs12995865 chr2:28025066 A/C cg27432699 chr2:27873401 GPN1 0.45 5.73 0.3 2.24e-8 Response to carboplatin and paclitaxel in ovarian cancer (Caspase 3/7 EC50); CRC cis rs17270561 0.583 rs6926425 chr6:25785304 T/C cg16482183 chr6:26056742 HIST1H1C 0.61 8.23 0.41 4.56e-15 Iron status biomarkers; CRC cis rs9311676 0.656 rs62258102 chr3:58378784 T/C cg06643156 chr3:58380774 PXK 0.41 6.33 0.33 7.82e-10 Systemic lupus erythematosus; CRC cis rs11764590 0.715 rs56289396 chr7:2091415 G/A cg23422044 chr7:1970798 MAD1L1 -0.51 -5.99 -0.31 5.47e-9 Neuroticism; CRC cis rs7918232 0.941 rs7907988 chr10:27444344 T/G cg14240646 chr10:27532245 ACBD5 -0.87 -9.89 -0.48 2.34e-20 Breast cancer; CRC cis rs9858542 0.953 rs11922013 chr3:49458355 G/C cg03060546 chr3:49711283 APEH -0.47 -6.7 -0.35 9.06e-11 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC trans rs1814175 0.669 rs12364577 chr11:49707361 A/C cg11707556 chr5:10655725 ANKRD33B -0.38 -7.16 -0.37 5.44e-12 Height; CRC cis rs2996428 0.504 rs3765780 chr1:3767696 C/T cg13057898 chr1:3703894 LRRC47 -0.4 -5.87 -0.31 1.06e-8 Red cell distribution width; CRC cis rs2739330 0.731 rs4822450 chr22:24242887 C/T cg04234412 chr22:24373322 LOC391322 -0.78 -12.97 -0.58 2.34e-31 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs6840360 0.554 rs58751443 chr4:152709905 A/G cg09659197 chr4:152720779 NA 0.42 8.5 0.42 6.93e-16 Intelligence (multi-trait analysis); CRC cis rs57221529 0.766 rs72703070 chr5:590458 T/C cg09021430 chr5:549028 NA -0.7 -7.75 -0.39 1.17e-13 Lung disease severity in cystic fibrosis; CRC cis rs11971779 0.553 rs7799742 chr7:139051878 C/T cg07862535 chr7:139043722 LUC7L2 0.57 7.32 0.37 1.97e-12 Diisocyanate-induced asthma; CRC cis rs1799949 1.000 rs4792981 chr17:41308274 A/G cg01879757 chr17:41196368 BRCA1 -0.43 -6.53 -0.34 2.51e-10 Menopause (age at onset); CRC cis rs10504229 0.724 rs73603871 chr8:58107612 A/G cg04204079 chr8:58130323 NA -0.46 -5.79 -0.3 1.67e-8 Developmental language disorder (linguistic errors); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg10235961 chr3:48471218 PLXNB1 0.48 6.76 0.35 6.2e-11 Response to antipsychotic treatment; CRC cis rs2180341 0.961 rs9375501 chr6:127652539 C/T cg24812749 chr6:127587940 RNF146 0.94 13.66 0.6 5.88e-34 Breast cancer; CRC cis rs4665809 1.000 rs17040322 chr2:26351274 G/C cg25036284 chr2:26402008 FAM59B -0.46 -5.97 -0.31 6e-9 Gut microbiome composition (summer); CRC cis rs10504229 1.000 rs76944716 chr8:58191643 T/C cg24829409 chr8:58192753 C8orf71 -0.68 -10.89 -0.51 8.91e-24 Developmental language disorder (linguistic errors); CRC cis rs2046867 0.862 rs6805234 chr3:72829869 A/G cg25664220 chr3:72788482 NA -0.41 -6.42 -0.33 4.67e-10 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; CRC cis rs11098499 0.698 rs4422403 chr4:120258194 C/T cg09307838 chr4:120376055 NA 0.6 9.33 0.46 1.62e-18 Corneal astigmatism; CRC cis rs4713118 0.869 rs6922574 chr6:27693003 A/T cg19041857 chr6:27730383 NA -0.45 -6.39 -0.33 5.52e-10 Parkinson's disease; CRC cis rs1799949 1.000 rs33945274 chr17:41280073 G/A cg25072359 chr17:41440525 NA 0.46 6.93 0.36 2.19e-11 Menopause (age at onset); CRC cis rs1153858 1.000 rs12437887 chr15:45669094 G/A cg21132104 chr15:45694354 SPATA5L1 0.57 8.24 0.41 4.06e-15 Homoarginine levels; CRC cis rs34779708 0.931 rs12771399 chr10:35452377 C/T cg03585969 chr10:35415529 CREM 0.66 8.65 0.43 2.39e-16 Inflammatory bowel disease;Crohn's disease; CRC cis rs1506636 0.962 rs17623873 chr7:123417100 C/A cg03229431 chr7:123269106 ASB15 0.75 11.0 0.52 3.53e-24 Plateletcrit;Platelet count; CRC cis rs12476592 0.516 rs11883730 chr2:63592230 A/C cg10828910 chr2:63850056 LOC388955 -0.49 -6.0 -0.31 5.17e-9 Childhood ear infection; CRC cis rs7927771 0.832 rs4752993 chr11:47410951 T/C cg05585544 chr11:47624801 NA 0.53 9.31 0.46 1.84e-18 Subjective well-being; CRC cis rs2629540 0.889 rs4962696 chr10:126445630 A/G cg08799069 chr10:126477246 METTL10 -0.63 -8.51 -0.42 6.45e-16 Cocaine dependence; CRC cis rs4654899 0.758 rs17453044 chr1:21517361 A/G cg02927042 chr1:21476669 EIF4G3 -0.4 -6.22 -0.32 1.49e-9 Superior frontal gyrus grey matter volume; CRC cis rs10540 1.000 rs61876341 chr11:495892 C/G cg03352830 chr11:487213 PTDSS2 0.67 7.7 0.39 1.63e-13 Body mass index; CRC cis rs2160860 0.729 rs7845003 chr8:39799765 C/T cg11363097 chr8:39792086 IDO2 -0.45 -7.65 -0.39 2.28e-13 Blood metabolite levels; CRC cis rs7804356 0.906 rs17323934 chr7:26904330 C/G cg03456212 chr7:26904342 SKAP2 0.55 6.44 0.33 4.21e-10 Type 1 diabetes; CRC cis rs12594515 0.967 rs12595138 chr15:45986108 G/C cg01629716 chr15:45996671 NA 0.4 8.25 0.41 3.97e-15 Waist circumference;Weight; CRC cis rs3749237 1.000 rs11130216 chr3:49736172 C/A cg03060546 chr3:49711283 APEH 0.52 7.74 0.39 1.24e-13 Resting heart rate; CRC cis rs9611565 0.512 rs715498 chr22:42148467 G/A cg06634786 chr22:41940651 POLR3H 0.66 7.33 0.37 1.79e-12 Vitiligo; CRC cis rs853679 0.517 rs9366715 chr6:28064633 A/G cg15786705 chr6:28176104 NA 0.76 9.6 0.47 2.1e-19 Depression; CRC cis rs4481887 0.745 rs4540687 chr1:248476099 C/G cg00666640 chr1:248458726 OR2T12 0.48 8.14 0.41 7.98e-15 Common traits (Other); CRC cis rs7647973 1.000 rs7647973 chr3:49510931 G/A cg20833759 chr3:49053208 WDR6;DALRD3 -0.62 -9.13 -0.45 7.11e-18 Menarche (age at onset); CRC cis rs875971 0.619 rs2302918 chr7:66000932 A/G cg11764359 chr7:65958608 NA 0.54 8.31 0.42 2.46e-15 Aortic root size; CRC cis rs4819052 1.000 rs2838847 chr21:46670958 G/C cg19498844 chr21:46707878 POFUT2;LOC642852 0.79 10.8 0.51 1.77e-23 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC trans rs5756813 0.688 rs5995498 chr22:38196573 T/G cg19894588 chr14:64061835 NA -0.62 -8.41 -0.42 1.3e-15 Optic cup area;Vertical cup-disc ratio; CRC cis rs62064224 0.614 rs4794923 chr17:30763009 G/A cg09324608 chr17:30823087 MYO1D 0.35 5.91 0.31 8.67e-9 Schizophrenia; CRC cis rs116095464 1.000 rs28416084 chr5:217640 G/A cg22857025 chr5:266934 NA -1.14 -12.02 -0.55 7.44e-28 Breast cancer; CRC cis rs6089584 0.586 rs4925216 chr20:60599923 G/A cg13770153 chr20:60521292 NA -0.41 -6.31 -0.33 8.9e-10 Body mass index; CRC cis rs736408 0.521 rs13074853 chr3:52779801 T/C cg18099408 chr3:52552593 STAB1 -0.47 -7.89 -0.4 4.59e-14 Bipolar disorder; CRC cis rs11098499 0.866 rs6824111 chr4:120285968 T/A cg09307838 chr4:120376055 NA 0.68 10.53 0.5 1.51e-22 Corneal astigmatism; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg18030545 chr6:107077498 QRSL1;RTN4IP1 0.46 6.61 0.34 1.58e-10 Response to antipsychotic treatment; CRC cis rs2739330 0.760 rs5751760 chr22:24243573 G/A cg15242686 chr22:24348715 GSTTP1 0.38 5.74 0.3 2.12e-8 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs3858526 0.796 rs9645652 chr11:5944264 C/T cg13902645 chr11:5959945 NA -0.61 -8.41 -0.42 1.29e-15 DNA methylation (variation); CRC cis rs4474465 1.000 rs7925034 chr11:78193242 A/G cg27205649 chr11:78285834 NARS2 -0.48 -5.84 -0.31 1.25e-8 Alzheimer's disease (survival time); CRC cis rs8180040 0.627 rs9821119 chr3:47198437 C/G cg27129171 chr3:47204927 SETD2 0.72 11.38 0.53 1.64e-25 Colorectal cancer; CRC cis rs1552244 0.572 rs3843008 chr3:10173742 C/T cg08888203 chr3:10149979 C3orf24 0.7 7.42 0.38 1.03e-12 Alzheimer's disease; CRC cis rs9549367 0.577 rs3024711 chr13:113813268 A/G cg18105134 chr13:113819100 PROZ -0.71 -9.09 -0.45 9.8e-18 Platelet distribution width; CRC cis rs4285028 0.948 rs34158925 chr3:121678465 C/A cg11130432 chr3:121712080 ILDR1 -0.52 -6.75 -0.35 6.81e-11 Multiple sclerosis; CRC cis rs2836974 0.932 rs6517526 chr21:40581530 T/C cg11644478 chr21:40555479 PSMG1 0.81 12.39 0.56 3.3600000000000003e-29 Cognitive function; CRC cis rs10256972 0.591 rs11766651 chr7:1161646 A/G cg03188948 chr7:1209495 NA 0.5 7.24 0.37 3.1e-12 Longevity;Endometriosis; CRC cis rs6764363 0.527 rs7640724 chr3:283039 G/A cg02057681 chr3:285234 CHL1 0.42 7.08 0.36 8.63e-12 Sudden cardiac arrest; CRC cis rs9527 0.545 rs10218853 chr10:104796787 A/C cg04362960 chr10:104952993 NT5C2 0.6 8.6 0.43 3.34e-16 Arsenic metabolism; CRC cis rs11122272 0.675 rs1416913 chr1:231533206 A/C cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.58 -8.61 -0.43 2.98e-16 Hemoglobin concentration; CRC cis rs2836754 1.000 rs11701004 chr21:40292102 C/G cg02119577 chr21:40195074 ETS2 -0.35 -6.0 -0.31 5.17e-9 Crohn's disease;Body mass index; CRC cis rs826838 0.802 rs10785619 chr12:38742897 T/A cg26384229 chr12:38710491 ALG10B 0.66 9.88 0.48 2.46e-20 Heart rate; CRC cis rs10878977 0.542 rs12368608 chr12:69814447 C/G cg20891283 chr12:69753455 YEATS4 -0.6 -5.91 -0.31 8.6e-9 Colorectal cancer; CRC cis rs7618915 0.501 rs10865974 chr3:52718280 A/C cg18099408 chr3:52552593 STAB1 0.46 7.87 0.4 5.16e-14 Bipolar disorder; CRC cis rs2228479 0.764 rs7186976 chr16:89961593 A/G cg06558623 chr16:89946397 TCF25 0.79 8.65 0.43 2.34e-16 Skin colour saturation; CRC cis rs1862618 0.853 rs1423621 chr5:56101035 G/T cg20203395 chr5:56204925 C5orf35 -0.6 -6.98 -0.36 1.61e-11 Initial pursuit acceleration; CRC cis rs6909279 0.678 rs6557143 chr6:151848611 G/A cg10883421 chr6:151773342 RMND1;C6orf211 -0.38 -5.72 -0.3 2.34e-8 Bone mineral density; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg04418576 chr14:103851554 MARK3 0.46 6.0 0.31 5.06e-9 Thyroid stimulating hormone; CRC cis rs10791323 0.628 rs2853117 chr11:133705266 T/G cg15485101 chr11:133734466 NA 0.4 6.91 0.36 2.45e-11 Childhood ear infection; CRC trans rs3780486 0.505 rs10117038 chr9:33122626 T/C cg04842962 chr6:43655489 MRPS18A 0.92 16.49 0.67 5.85e-45 IgG glycosylation; CRC cis rs7829975 0.902 rs777707 chr8:8584344 A/G cg08975724 chr8:8085496 FLJ10661 0.42 6.56 0.34 2.15e-10 Mood instability; CRC cis rs9903692 0.754 rs12602948 chr17:46190929 G/A cg21215337 chr17:46176117 CBX1 -0.43 -7.95 -0.4 2.95e-14 Pulse pressure; CRC cis rs4819052 0.679 rs28623526 chr21:46712324 T/C cg19498844 chr21:46707878 POFUT2;LOC642852 0.65 9.93 0.48 1.69e-20 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs67311347 0.544 rs4974047 chr3:40339653 G/T cg09455208 chr3:40491958 NA 0.31 6.31 0.33 8.76e-10 Renal cell carcinoma; CRC cis rs72781680 0.898 rs72782137 chr2:24047805 C/T cg08917208 chr2:24149416 ATAD2B 0.9 8.87 0.44 4.67e-17 Lymphocyte counts; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg24511898 chr2:242576823 ATG4B;THAP4 0.46 6.53 0.34 2.46e-10 Response to antipsychotic treatment; CRC cis rs1448094 0.842 rs12809288 chr12:86455427 C/T cg02569458 chr12:86230093 RASSF9 -0.42 -7.04 -0.36 1.15e-11 Major depressive disorder; CRC cis rs4689592 0.503 rs4689064 chr4:7055603 A/G cg06697600 chr4:7070879 GRPEL1 0.55 7.23 0.37 3.35e-12 Monocyte percentage of white cells; CRC cis rs9911578 1.000 rs9911578 chr17:56953147 C/T cg12560992 chr17:57184187 TRIM37 0.92 17.0 0.68 6.03e-47 Intelligence (multi-trait analysis); CRC cis rs1891275 0.515 rs1361552 chr10:93534624 T/C cg07889827 chr10:93443413 NA -0.39 -6.57 -0.34 1.92e-10 Intelligence (multi-trait analysis); CRC trans rs7582720 1.000 rs72934704 chr2:203706433 C/T cg23104954 chr13:50701501 NA -0.52 -6.02 -0.31 4.74e-9 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; CRC cis rs7589728 0.620 rs76687350 chr2:88473832 G/A cg04511125 chr2:88470314 THNSL2 0.78 8.02 0.4 1.92e-14 Plasma clusterin levels; CRC cis rs7927592 0.913 rs11228276 chr11:68307525 A/G cg01657329 chr11:68192670 LRP5 -0.46 -6.58 -0.34 1.89e-10 Total body bone mineral density; CRC cis rs9682041 0.627 rs11917188 chr3:170088607 C/T cg11886554 chr3:170076028 SKIL 0.67 8.22 0.41 4.9e-15 Glomerular filtration rate in non diabetics (creatinine);Glomerular filtration rate (creatinine); CRC cis rs11676348 0.818 rs4674256 chr2:218987893 A/T cg00012203 chr2:219082015 ARPC2 -0.43 -6.31 -0.33 8.79e-10 Ulcerative colitis; CRC cis rs7089973 0.934 rs68085797 chr10:116632130 A/T cg23260525 chr10:116636907 FAM160B1 0.33 6.47 0.34 3.48e-10 Bipolar disorder or attention deficit hyperactivity disorder; CRC cis rs13108904 0.905 rs1732108 chr4:1276550 C/T cg21620606 chr4:1342894 KIAA1530 -0.34 -5.76 -0.3 1.97e-8 Obesity-related traits; CRC cis rs10979 0.931 rs9484771 chr6:143896897 T/A cg25407410 chr6:143891975 LOC285740 -0.84 -13.84 -0.61 1.22e-34 Hypospadias; CRC cis rs9487051 0.802 rs6568558 chr6:109592701 A/T cg21918786 chr6:109611834 NA -0.43 -7.84 -0.4 6.27e-14 Reticulocyte fraction of red cells; CRC cis rs7726839 0.540 rs72703092 chr5:599269 G/A cg14541582 chr5:601475 NA -0.37 -7.38 -0.38 1.27e-12 Obesity-related traits; CRC cis rs1577917 0.883 rs2660575 chr6:86684995 C/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.44 -5.91 -0.31 8.63e-9 Response to antipsychotic treatment; CRC cis rs8013055 0.796 rs8005568 chr14:105971794 A/G cg19882132 chr14:106167949 NA -0.41 -6.21 -0.32 1.62e-9 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis); CRC cis rs28386778 0.799 rs2955234 chr17:61983601 A/C cg11494091 chr17:61959527 GH2 -0.74 -14.06 -0.61 1.67e-35 Prudent dietary pattern; CRC cis rs9399135 1.000 rs9399135 chr6:135368314 G/A cg22676075 chr6:135203613 NA 0.38 5.81 0.31 1.46e-8 Red blood cell count; CRC cis rs2971970 0.519 rs10232278 chr7:133628547 G/A cg03336402 chr7:133662267 EXOC4 0.63 9.64 0.47 1.5700000000000001e-19 Intelligence (multi-trait analysis); CRC cis rs9916302 0.904 rs8079303 chr17:37530755 G/C cg07936489 chr17:37558343 FBXL20 0.85 13.55 0.6 1.57e-33 Glomerular filtration rate (creatinine); CRC trans rs9903692 0.954 rs12936731 chr17:46128359 G/C cg13910583 chr8:56987998 RPS20 -0.44 -5.99 -0.31 5.63e-9 Pulse pressure; CRC trans rs7618501 0.519 rs3774749 chr3:50207227 C/T cg21665057 chr3:196295764 WDR53;FBXO45 -0.5 -7.83 -0.4 6.67e-14 Intelligence (multi-trait analysis); CRC trans rs7448080 0.702 rs62371207 chr5:123304036 T/G cg23202058 chr4:185139648 ENPP6 0.62 6.46 0.34 3.77e-10 Alcohol dependence (age at onset); CRC cis rs11105298 0.891 rs10777163 chr12:89830720 T/C cg08166232 chr12:89918718 WDR51B;GALNT4 -0.49 -6.28 -0.33 1.1e-9 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; CRC cis rs2932538 0.961 rs2932534 chr1:113200797 A/G cg22162597 chr1:113214053 CAPZA1 0.69 10.04 0.48 7.33e-21 Systolic blood pressure;Diastolic blood pressure;Hypertension;Blood pressure; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg27265118 chr3:4344949 SETMAR 0.49 7.27 0.37 2.58e-12 Intelligence (multi-trait analysis); CRC cis rs10971721 0.731 rs12378261 chr9:33837172 C/T cg13495928 chr9:33750294 PRSS3 0.55 5.93 0.31 7.7e-9 Body mass index; CRC cis rs7659604 0.628 rs6838153 chr4:122720999 A/G cg20573242 chr4:122745356 CCNA2 0.53 7.62 0.39 2.65e-13 Type 2 diabetes; CRC cis rs7119 0.717 rs12902925 chr15:77819141 T/C cg27398640 chr15:77910606 LINGO1 -0.44 -7.53 -0.38 5e-13 Type 2 diabetes; CRC cis rs10078 0.510 rs2278248 chr5:469570 G/T cg07599136 chr5:415885 AHRR 0.62 6.49 0.34 3.15e-10 Fat distribution (HIV); CRC cis rs9811920 0.609 rs812657 chr3:99566329 T/C cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G -0.47 -6.22 -0.32 1.51e-9 Axial length; CRC cis rs6964587 0.900 rs4279 chr7:91764128 C/A cg17063962 chr7:91808500 NA 0.83 14.48 0.62 4.11e-37 Breast cancer; CRC cis rs4466137 1.000 rs4466137 chr5:82985739 A/C cg15083037 chr5:83017644 HAPLN1 -0.46 -6.28 -0.33 1.08e-9 Prostate cancer; CRC cis rs12024301 0.557 rs76628322 chr1:183625835 G/A cg11505048 chr1:183622726 RGL1;APOBEC4 0.75 6.51 0.34 2.76e-10 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs4332037 0.539 rs56016347 chr7:2060126 C/T cg21155852 chr7:2048760 MAD1L1 -0.49 -6.63 -0.34 1.35e-10 Bipolar disorder; CRC cis rs7916697 0.520 rs4745957 chr10:70044702 A/G cg06988349 chr10:69991859 ATOH7 -0.33 -5.85 -0.31 1.17e-8 Optic disc area; CRC trans rs6762477 0.748 rs2073726 chr3:50223593 T/A cg21665057 chr3:196295764 WDR53;FBXO45 -0.43 -6.6 -0.34 1.66e-10 Menarche (age at onset); CRC cis rs9322193 0.884 rs2342858 chr6:150127103 C/T cg07701084 chr6:150067640 NUP43 0.46 6.48 0.34 3.27e-10 Lung cancer; CRC cis rs2882667 0.894 rs10054478 chr5:138354075 G/A cg04439458 chr5:138467593 SIL1 -0.32 -5.86 -0.31 1.11e-8 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs7615952 0.599 rs6438953 chr3:125724951 T/C cg15145296 chr3:125709740 NA -0.54 -7.03 -0.36 1.19e-11 Blood pressure (smoking interaction); CRC cis rs7177699 0.526 rs7165042 chr15:79123338 C/G cg15571903 chr15:79123663 NA 0.34 6.92 0.36 2.4e-11 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; CRC cis rs5751901 0.688 rs2017869 chr22:24997309 C/G cg15363607 chr22:24998974 GGT1 -0.42 -6.81 -0.35 4.55e-11 Protein quantitative trait loci; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg27055842 chr21:33765028 C21orf119;URB1 0.37 5.99 0.31 5.46e-9 Liver disease severity in Alagille syndrome; CRC cis rs4692589 1.000 rs11732126 chr4:170937416 A/G cg19918862 chr4:170955249 NA 0.39 6.39 0.33 5.54e-10 Anxiety disorder; CRC cis rs13631 0.697 rs1018330 chr9:139980385 A/C cg03717367 chr9:139980219 LOC100289341;MAN1B1 0.34 6.51 0.34 2.85e-10 Cerebrospinal fluid biomarker levels; CRC cis rs7811142 0.943 rs73403312 chr7:100024153 T/C cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.62 8.15 0.41 7.87e-15 Platelet count; CRC cis rs10504229 0.728 rs17804365 chr8:58151537 C/A cg22535103 chr8:58192502 C8orf71 -0.68 -8.37 -0.42 1.72e-15 Developmental language disorder (linguistic errors); CRC cis rs13108904 0.870 rs4974543 chr4:1251222 A/G cg19318889 chr4:1322082 MAEA 0.41 5.95 0.31 6.97e-9 Obesity-related traits; CRC cis rs875971 0.660 rs10215132 chr7:66054406 C/A cg25985355 chr7:65971099 NA 0.32 5.71 0.3 2.55e-8 Aortic root size; CRC cis rs637571 0.780 rs677029 chr11:65683531 A/G cg26695010 chr11:65641043 EFEMP2 -0.45 -6.47 -0.34 3.48e-10 Eosinophil percentage of white cells; CRC cis rs6860806 0.507 rs270601 chr5:131656997 T/C cg02033258 chr5:131593261 PDLIM4 0.38 6.38 0.33 6.15e-10 Breast cancer; CRC cis rs2303745 0.544 rs6512181 chr19:17399213 T/G cg04248312 chr19:17393744 ANKLE1 -0.97 -14.43 -0.62 6.3e-37 Systemic lupus erythematosus; CRC cis rs933688 1.000 rs10059163 chr5:90742444 C/T cg26981201 chr5:90679533 LOC100129716;ARRDC3 1.0 16.26 0.67 4.86e-44 Smoking behavior; CRC cis rs9916302 0.904 rs8076494 chr17:37516722 A/G cg00129232 chr17:37814104 STARD3 0.52 7.42 0.38 1.03e-12 Glomerular filtration rate (creatinine); CRC cis rs1949733 1.000 rs868105 chr4:8501030 G/T cg11789530 chr4:8429930 ACOX3 -0.83 -12.17 -0.56 2.27e-28 Response to antineoplastic agents; CRC trans rs2797160 1.000 rs6569435 chr6:125998186 T/C cg05039488 chr6:79577232 IRAK1BP1 -0.5 -7.46 -0.38 7.63e-13 Endometrial cancer; CRC cis rs9393777 0.557 rs6933999 chr6:27074929 G/A cg12292205 chr6:26970375 C6orf41 -0.65 -8.47 -0.42 8.16e-16 Intelligence (multi-trait analysis); CRC cis rs3617 0.573 rs9825230 chr3:52901974 G/A cg10802521 chr3:52805072 NEK4 -0.39 -5.93 -0.31 7.52e-9 Red blood cell count;Autism spectrum disorder or schizophrenia; CRC cis rs7173389 1.000 rs11630367 chr15:73662855 A/G cg01796676 chr15:73680284 NA 0.51 6.8 0.35 5.01e-11 Resting heart rate; CRC cis rs155076 1.000 rs484365 chr13:21845944 G/T cg25811766 chr13:21894605 NA -0.57 -6.0 -0.31 5.12e-9 White matter hyperintensity burden; CRC trans rs4650994 0.525 rs17361286 chr1:178521916 C/G cg05059571 chr16:84539110 KIAA1609 -0.63 -8.73 -0.43 1.28e-16 HDL cholesterol levels;HDL cholesterol; CRC cis rs1448094 0.544 rs56330110 chr12:86166666 A/G cg00310523 chr12:86230176 RASSF9 0.39 6.36 0.33 6.59e-10 Major depressive disorder; CRC trans rs6561151 0.681 rs61959998 chr13:44462501 A/T cg17145862 chr1:211918768 LPGAT1 0.48 6.07 0.32 3.51e-9 Crohn's disease; CRC cis rs2559856 0.904 rs2695283 chr12:102089391 G/C cg12924262 chr12:102091054 CHPT1 0.54 8.15 0.41 7.8e-15 Blood protein levels; CRC cis rs7607369 0.559 rs13027908 chr2:219660374 T/C cg02176678 chr2:219576539 TTLL4 -0.38 -6.07 -0.32 3.58e-9 Red blood cell count;Amyotrophic lateral sclerosis; CRC cis rs8180040 0.967 rs4858890 chr3:47405456 A/G cg10298567 chr3:47292165 KIF9 0.44 7.03 0.36 1.19e-11 Colorectal cancer; CRC cis rs6502050 0.835 rs34620191 chr17:80149532 G/A cg22110888 chr17:80059540 CCDC57 0.4 6.24 0.33 1.33e-9 Life satisfaction; CRC cis rs4716602 0.542 rs35137250 chr7:156161066 T/C cg16983916 chr7:156159713 NA -0.39 -6.81 -0.35 4.57e-11 Anti-saccade response; CRC cis rs970548 0.657 rs11239572 chr10:46088061 C/T cg15590007 chr10:45870220 ALOX5 -0.56 -6.01 -0.31 4.98e-9 Total cholesterol levels;Cholesterol, total;HDL cholesterol;HDL cholesterol levels; CRC cis rs7727544 0.716 rs2089855 chr5:131573529 A/G cg14196790 chr5:131705035 SLC22A5 0.34 5.9 0.31 8.87e-9 Blood metabolite levels; CRC cis rs1003719 0.667 rs13050226 chr21:38457708 C/T cg10648535 chr21:38446584 PIGP;TTC3 0.46 6.22 0.32 1.51e-9 Eye color traits; CRC cis rs2075371 1.000 rs2544218 chr7:133992315 C/A cg20476274 chr7:133979776 SLC35B4 0.82 15.1 0.64 1.64e-39 Mean platelet volume; CRC cis rs526821 0.595 rs565859 chr11:55297367 T/C cg04317927 chr11:55418816 OR4S2 0.4 6.73 0.35 7.39e-11 Pediatric bone mineral density (spine); CRC trans rs2243480 0.706 rs34466769 chr7:65453292 A/C cg10756647 chr7:56101905 PSPH 0.69 8.32 0.42 2.29e-15 Diabetic kidney disease; CRC cis rs3096299 0.935 rs3102387 chr16:89432276 A/C cg01788221 chr16:89496183 ANKRD11 -0.38 -5.86 -0.31 1.12e-8 Multiple myeloma (IgH translocation); CRC cis rs6089584 0.925 rs35683654 chr20:60625401 G/T cg18761221 chr20:60518478 NA -0.58 -9.14 -0.45 6.5e-18 Body mass index; CRC cis rs77686669 1 rs77686669 chr7:99744572 T/C cg13153964 chr7:100026424 MEPCE;ZCWPW1 0.52 6.83 0.35 3.99e-11 Venous thromboembolism adjusted for sickle cell variant rs77121243-T; CRC cis rs12549902 0.966 rs4737000 chr8:41509727 A/C cg17182837 chr8:41585554 ANK1 -0.4 -6.25 -0.33 1.3e-9 Corrected insulin response;Corrected insulin response adjusted for insulin sensitivity index;Insulin levels adjusted for BMI;Type 2 diabetes; CRC cis rs2495707 0.647 rs1541266 chr10:102421292 C/T cg08729031 chr10:102416179 NA -0.42 -7.49 -0.38 6.37e-13 Body mass index; CRC cis rs10865541 0.967 rs6751808 chr2:3397377 A/G cg22182287 chr2:3452347 TTC15 0.38 5.92 0.31 8e-9 Obesity-related traits; CRC trans rs10802346 0.514 rs4443861 chr1:246372574 G/T cg13514129 chr1:39547527 MACF1 0.57 8.58 0.43 3.74e-16 Fractional exhaled nitric oxide (childhood); CRC cis rs3741404 0.537 rs1123251 chr11:63917601 G/T cg19465662 chr11:63993652 NUDT22;TRPT1 -0.59 -8.76 -0.44 1.01e-16 Platelet count; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg25009629 chr6:41748519 FRS3;PRICKLE4 -0.41 -6.16 -0.32 2.07e-9 Myopia (pathological); CRC trans rs7615952 0.512 rs11921452 chr3:125359750 A/G cg07211511 chr3:129823064 LOC729375 -0.63 -8.76 -0.43 1.03e-16 Blood pressure (smoking interaction); CRC cis rs7973719 0.868 rs12825629 chr12:7355583 T/C cg07052231 chr12:7363540 PEX5 0.52 8.34 0.42 2.08e-15 IgG glycosylation; CRC trans rs3780486 1.000 rs3780480 chr9:33163486 G/T cg20290983 chr6:43655470 MRPS18A 1.04 16.68 0.68 1.03e-45 IgG glycosylation; CRC cis rs2731664 0.756 rs2545796 chr5:176864269 T/C cg23176889 chr5:176863531 GRK6 -0.72 -15.63 -0.65 1.36e-41 Intelligence (multi-trait analysis); CRC cis rs651907 0.557 rs12629658 chr3:101356535 A/G cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.64 8.65 0.43 2.33e-16 Colorectal cancer; CRC cis rs2070488 0.965 rs2366123 chr3:38493153 G/A cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.91 17.03 0.68 4.35e-47 Electrocardiographic conduction measures; CRC cis rs2386661 0.826 rs4427479 chr10:5682855 T/C cg26603656 chr10:5671107 NA -0.49 -8.06 -0.41 1.4e-14 Breast cancer; CRC cis rs60871478 0.787 rs4720928 chr7:808002 T/C cg05535760 chr7:792225 HEATR2 0.81 11.04 0.52 2.6e-24 Cerebrospinal P-tau181p levels; CRC cis rs16852403 0.548 rs10913524 chr1:178221107 T/C cg00404053 chr1:178313656 RASAL2 0.52 6.75 0.35 6.58e-11 Childhood ear infection; CRC cis rs834811 0.563 rs10225343 chr7:135886320 C/A cg01726295 chr7:135938950 NA 0.36 6.11 0.32 2.74e-9 Post-traumatic stress disorder; CRC cis rs6831352 0.589 rs2602836 chr4:100014805 C/T cg13256891 chr4:100009986 ADH5 -0.6 -8.96 -0.44 2.56e-17 Alcohol dependence; CRC cis rs9468186 1 rs9468186 chr6:27626631 A/G cg08798685 chr6:27730294 NA -0.46 -6.2 -0.32 1.72e-9 Neuroticism; CRC cis rs738321 0.757 rs3788535 chr22:38534045 T/C cg25457927 chr22:38595422 NA -0.3 -5.68 -0.3 2.98e-8 Breast cancer; CRC cis rs897984 0.806 rs1458202 chr16:30953202 A/G cg02466173 chr16:30829666 NA -0.66 -10.04 -0.48 7.24e-21 Dementia with Lewy bodies; CRC cis rs9733 0.596 rs72700897 chr1:150626038 C/G cg17724175 chr1:150552817 MCL1 0.58 9.4 0.46 9.25e-19 Tonsillectomy; CRC cis rs17384381 0.863 rs12140272 chr1:85789757 G/A cg16011679 chr1:85725395 C1orf52 0.54 5.83 0.31 1.32e-8 Lobe attachment (rater-scored or self-reported); CRC cis rs7811142 1.000 rs7783159 chr7:100017454 C/T cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.14 15.79 0.66 3.5e-42 Platelet count; CRC cis rs6952808 0.825 rs4236277 chr7:1942270 C/T cg04267008 chr7:1944627 MAD1L1 -0.84 -12.91 -0.58 4.01e-31 Bipolar disorder and schizophrenia; CRC cis rs3736485 0.844 rs11070853 chr15:51784203 A/G cg08986416 chr15:51914746 DMXL2 -0.44 -6.33 -0.33 8.1e-10 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs939584 0.935 rs7604752 chr2:643428 C/A cg03610516 chr2:642275 NA 0.42 5.88 0.31 9.94e-9 Body mass index; CRC cis rs11098499 0.789 rs9991166 chr4:120237851 G/A cg09307838 chr4:120376055 NA 0.62 9.75 0.47 6.92e-20 Corneal astigmatism; CRC cis rs7493 0.950 rs17166868 chr7:95033416 C/T cg01874867 chr7:94954059 PON1 -0.52 -6.59 -0.34 1.74e-10 Yu-Zhi constitution type in type 2 diabetes; CRC trans rs1728785 1.000 rs1728781 chr16:68567794 A/T cg04657470 chr2:198365150 HSPE1;HSPD1 0.58 6.97 0.36 1.72e-11 Ulcerative colitis; CRC cis rs6088580 0.634 rs13041646 chr20:33082881 T/A cg08999081 chr20:33150536 PIGU 0.65 11.6 0.54 2.5e-26 Glomerular filtration rate (creatinine); CRC cis rs7527798 0.592 rs6684643 chr1:207846242 A/T cg21110645 chr1:207815933 NA -0.41 -6.24 -0.33 1.35e-9 Erythrocyte sedimentation rate; CRC cis rs9648716 1.000 rs6950312 chr7:140572183 T/A cg10747023 chr7:140774559 NA 0.44 5.69 0.3 2.89e-8 Type 2 diabetes; CRC cis rs8031584 0.541 rs2959037 chr15:31218164 T/C cg19680485 chr15:31195859 MTMR15 0.48 6.68 0.35 1.04e-10 Huntington's disease progression; CRC cis rs2878628 0.650 rs56098033 chr3:52758571 T/A cg15147215 chr3:52552868 STAB1 -0.63 -10.66 -0.51 5.33e-23 Intelligence (multi-trait analysis); CRC cis rs910316 0.737 rs175049 chr14:75481368 C/T cg03030879 chr14:75389066 RPS6KL1 0.43 6.55 0.34 2.23e-10 Height; CRC trans rs7267979 1.000 rs7343481 chr20:25300113 C/T cg17903999 chr18:56338584 MALT1 0.42 6.93 0.36 2.23e-11 Liver enzyme levels (alkaline phosphatase); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg15120237 chr17:7747620 KDM6B 0.46 6.56 0.34 2.09e-10 Response to antipsychotic treatment; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg08402873 chr20:10653164 JAG1 0.48 6.78 0.35 5.55e-11 Response to antipsychotic treatment; CRC cis rs7224685 0.501 rs812996 chr17:3965674 T/C cg09597638 chr17:3907349 NA 0.64 11.62 0.54 2.26e-26 Type 2 diabetes; CRC trans rs853679 1.000 rs853685 chr6:28288785 C/T cg06606381 chr12:133084897 FBRSL1 -0.63 -6.45 -0.34 4.05e-10 Depression; CRC cis rs13191362 0.935 rs34268859 chr6:162934731 G/A cg06582575 chr6:163149167 PACRG;PARK2 0.77 9.25 0.45 2.88e-18 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs10791323 0.604 rs2257010 chr11:133712348 G/A cg03690763 chr11:133734501 NA -0.36 -6.05 -0.32 3.89e-9 Childhood ear infection; CRC cis rs7945718 0.621 rs6485977 chr11:12678387 C/T cg25843174 chr11:12811716 TEAD1 0.39 7.41 0.38 1.05e-12 Educational attainment (years of education); CRC cis rs12477438 0.765 rs1115756 chr2:99659845 C/A cg14399236 chr2:99771627 LIPT1;TSGA10 -0.6 -8.19 -0.41 6.03e-15 Chronic sinus infection; CRC cis rs4819052 0.851 rs35064782 chr21:46674360 G/A cg19498844 chr21:46707878 POFUT2;LOC642852 0.78 11.32 0.53 2.56e-25 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs10927875 0.722 rs6696912 chr1:16338474 T/C cg22431228 chr1:16359049 CLCNKA -0.43 -7.55 -0.38 4.24e-13 Dilated cardiomyopathy; CRC cis rs12476592 0.602 rs1356390 chr2:63669625 C/T cg10828910 chr2:63850056 LOC388955 -0.46 -5.72 -0.3 2.39e-8 Childhood ear infection; CRC cis rs7786808 0.778 rs34212455 chr7:158224490 C/T cg09998033 chr7:158218633 PTPRN2 -0.64 -9.03 -0.45 1.46e-17 Obesity-related traits; CRC cis rs853679 0.517 rs4713135 chr6:28039586 G/A cg03623178 chr6:28175578 NA 0.93 12.17 0.56 2.25e-28 Depression; CRC cis rs1552244 1.000 rs67852463 chr3:10157205 G/C cg13047869 chr3:10149882 C3orf24 0.6 8.0 0.4 2.09e-14 Alzheimer's disease; CRC cis rs394563 0.726 rs6942381 chr6:149662991 G/C cg16235748 chr6:149772707 ZC3H12D 0.38 7.05 0.36 1.09e-11 Dupuytren's disease; CRC cis rs1448094 0.511 rs10863071 chr12:86145813 A/G cg02569458 chr12:86230093 RASSF9 -0.46 -7.73 -0.39 1.32e-13 Major depressive disorder; CRC trans rs2012709 0.901 rs56121682 chr5:32554712 T/G cg03755955 chr8:6424269 MCPH1 0.44 6.43 0.33 4.39e-10 Breast cancer; CRC cis rs644799 1.000 rs563653 chr11:95561488 T/G cg25478527 chr11:95522999 CEP57;FAM76B 0.52 7.86 0.4 5.6e-14 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs5750830 0.569 rs5750809 chr22:39791491 T/G cg25459000 chr22:39777742 SYNGR1 -0.32 -5.7 -0.3 2.63e-8 Intelligence (multi-trait analysis); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg24306779 chr16:58060336 MMP15 0.45 6.41 0.33 5.1e-10 Response to antipsychotic treatment; CRC cis rs11622475 0.953 rs6576012 chr14:104400159 T/C cg12183467 chr14:104352244 NA 0.5 6.82 0.35 4.36e-11 Bipolar disorder; CRC cis rs11212617 1.000 rs35244261 chr11:108283808 A/C cg01991180 chr11:108092276 ATM;NPAT -0.4 -5.79 -0.3 1.66e-8 Response to metformin in type 2 diabetes (glycemic); CRC cis rs13064411 0.696 rs6438156 chr3:113206929 C/A cg10517650 chr3:113235015 CCDC52 -0.4 -6.97 -0.36 1.73e-11 Response to simvastatin treatment (PCSK9 protein level change); CRC cis rs4731207 0.596 rs6952915 chr7:124685952 T/G cg23710748 chr7:124431027 NA -0.39 -6.14 -0.32 2.35e-9 Cutaneous malignant melanoma; CRC trans rs9693857 0.520 rs6601320 chr8:9355888 G/C cg06636001 chr8:8085503 FLJ10661 0.47 6.36 0.33 6.9e-10 Systolic blood pressure; CRC cis rs1552244 0.872 rs6803517 chr3:10065426 C/T cg00166722 chr3:10149974 C3orf24 0.65 8.86 0.44 5.13e-17 Alzheimer's disease; CRC cis rs597539 0.652 rs544370 chr11:68653232 C/T cg04772025 chr11:68637568 NA 0.49 7.76 0.39 1.11e-13 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs6558530 0.932 rs7842425 chr8:1706041 G/T cg19131313 chr8:1704013 NA -0.48 -6.66 -0.34 1.12e-10 Systolic blood pressure; CRC cis rs9788333 0.962 rs61951450 chr13:21886354 G/A cg21970626 chr13:21893289 NA -0.45 -8.37 -0.42 1.65e-15 Thiazide-induced adverse metabolic effects in hypertensive patients; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg15094104 chr5:133406808 NA 0.49 6.63 0.34 1.36e-10 Thyroid stimulating hormone; CRC cis rs9814567 0.858 rs4955548 chr3:134341060 A/C cg06109529 chr3:134205091 CEP63;ANAPC13 -0.74 -10.73 -0.51 3.15e-23 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs6543140 0.964 rs7561351 chr2:103077780 A/G cg03938978 chr2:103052716 IL18RAP 0.41 6.54 0.34 2.37e-10 Blood protein levels; CRC cis rs957448 1.000 rs12679345 chr8:95564533 A/G cg26464482 chr8:95565502 KIAA1429 -0.44 -5.62 -0.3 4.14e-8 Nonsyndromic cleft lip with cleft palate; CRC cis rs6570726 0.791 rs370654 chr6:145879005 C/G cg13319975 chr6:146136371 FBXO30 -0.44 -6.52 -0.34 2.66e-10 Lobe attachment (rater-scored or self-reported); CRC cis rs2576037 0.562 rs612519 chr18:44379490 G/A cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.64 11.1 0.52 1.57e-24 Personality dimensions; CRC cis rs4731207 0.662 rs6973134 chr7:124515373 G/A cg23710748 chr7:124431027 NA -0.38 -6.08 -0.32 3.42e-9 Cutaneous malignant melanoma; CRC cis rs2077654 0.822 rs12279699 chr11:17443348 G/A cg25308976 chr11:17434268 ABCC8 0.79 5.87 0.31 1.05e-8 Gout; CRC cis rs1178968 1.000 rs917247 chr7:72761420 C/T cg25889504 chr7:72793014 NA -0.5 -6.15 -0.32 2.24e-9 Triglyceride levels; CRC cis rs7020830 0.898 rs13284651 chr9:37222681 G/T cg14294708 chr9:37120828 ZCCHC7 -1.04 -20.22 -0.74 1.18e-59 Schizophrenia; CRC trans rs11039798 0.588 rs11039818 chr11:48562120 C/T cg03929089 chr4:120376271 NA 0.65 7.04 0.36 1.11e-11 Axial length; CRC cis rs2298450 0.541 rs2835332 chr21:37656940 A/G cg02919814 chr21:37666008 DOPEY2 -0.44 -6.43 -0.33 4.4e-10 Schizophrenia; CRC cis rs977987 1.000 rs62060550 chr16:75502252 C/T cg03315344 chr16:75512273 CHST6 0.55 9.3 0.46 1.99e-18 Dupuytren's disease; CRC cis rs77633900 0.772 rs2944377 chr15:76699652 C/A cg21673338 chr15:77095150 SCAPER -0.66 -5.61 -0.3 4.23e-8 Non-glioblastoma glioma;Glioma; CRC cis rs4713118 0.513 rs149972 chr6:27983227 C/T cg02631126 chr6:28058918 ZSCAN12L1 0.24 5.76 0.3 1.95e-8 Parkinson's disease; CRC cis rs807029 0.577 rs701834 chr10:102761801 C/T cg04662943 chr10:102668895 NA 0.6 7.16 0.37 5.24e-12 Ejection fraction in Tripanosoma cruzi seropositivity; CRC cis rs13118159 0.872 rs1882105 chr4:1345956 T/C cg20092199 chr4:1342459 KIAA1530 0.45 7.75 0.39 1.13e-13 Longevity; CRC cis rs4713118 0.615 rs9295747 chr6:27736993 G/T cg20933634 chr6:27740509 NA -0.45 -6.55 -0.34 2.22e-10 Parkinson's disease; CRC cis rs6502050 0.799 rs7501461 chr17:80109806 C/T cg09264619 chr17:80180166 NA -0.34 -5.81 -0.3 1.5e-8 Life satisfaction; CRC cis rs4132509 0.592 rs12076373 chr1:243851947 G/C cg21452805 chr1:244014465 NA 0.59 7.37 0.38 1.38e-12 RR interval (heart rate); CRC cis rs7172809 0.607 rs77744673 chr15:77842311 T/C cg10437265 chr15:77819839 NA -0.36 -5.99 -0.31 5.65e-9 Glucose homeostasis traits; CRC cis rs720844 1.000 rs7571333 chr2:149335348 G/C cg09247360 chr2:149335327 NA -0.61 -7.57 -0.39 3.68e-13 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs2635047 0.811 rs12957869 chr18:44786869 C/G cg19077165 chr18:44547161 KATNAL2 -0.4 -6.2 -0.32 1.66e-9 Educational attainment; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg02263479 chr16:2097837 NTHL1;TSC2 0.46 6.5 0.34 2.97e-10 Anxiety disorder; CRC trans rs1499614 1.000 rs2707830 chr7:66167645 T/C cg10756647 chr7:56101905 PSPH 0.77 8.1 0.41 1.09e-14 Gout; CRC cis rs4713118 0.662 rs9468276 chr6:28027688 A/C cg12273811 chr6:28175739 NA 0.62 8.22 0.41 4.78e-15 Parkinson's disease; CRC cis rs4478858 0.735 rs12563669 chr1:31858067 A/G cg00250761 chr1:31883323 NA -0.4 -7.29 -0.37 2.29e-12 Alcohol dependence; CRC cis rs7772486 0.790 rs9403750 chr6:146167762 G/A cg05347473 chr6:146136440 FBXO30 0.37 5.75 0.3 2.01e-8 Lobe attachment (rater-scored or self-reported); CRC cis rs10504229 0.679 rs17800895 chr8:58050085 A/G cg22535103 chr8:58192502 C8orf71 -0.67 -7.5 -0.38 6.13e-13 Developmental language disorder (linguistic errors); CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg26147372 chr3:49130904 QRICH1 0.44 6.2 0.32 1.65e-9 Anxiety disorder; CRC cis rs644799 1.000 rs586498 chr11:95537828 C/T cg25622487 chr11:95524042 FAM76B;CEP57 0.76 11.87 0.55 2.62e-27 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs60871478 0.588 rs6952577 chr7:872100 C/T cg13844804 chr7:814759 HEATR2 0.58 6.44 0.33 4.12e-10 Cerebrospinal P-tau181p levels; CRC cis rs1215050 0.791 rs548892 chr4:98724701 C/T cg05340658 chr4:99064831 C4orf37 0.43 6.44 0.33 4.34e-10 Waist-to-hip ratio adjusted for body mass index; CRC cis rs17345786 0.628 rs11718446 chr3:101552553 C/T cg11279151 chr3:101281821 RG9MTD1 -0.53 -6.84 -0.35 3.82e-11 Colonoscopy-negative controls vs population controls; CRC cis rs4665809 0.877 rs34536218 chr2:26287376 T/A cg22920501 chr2:26401640 FAM59B 0.55 6.64 0.34 1.29e-10 Gut microbiome composition (summer); CRC cis rs4664293 0.647 rs357028 chr2:160491842 A/G cg08347373 chr2:160653686 CD302 -0.39 -6.62 -0.34 1.5e-10 Monocyte percentage of white cells; CRC cis rs2153535 0.580 rs9393033 chr6:8521446 G/A cg07606381 chr6:8435919 SLC35B3 0.64 10.48 0.5 2.35e-22 Motion sickness; CRC cis rs11969893 0.850 rs9386260 chr6:101329428 G/A cg12253828 chr6:101329408 ASCC3 1.13 9.17 0.45 5.3e-18 Economic and political preferences (immigration/crime); CRC cis rs4862750 0.874 rs6822062 chr4:187895553 T/C cg07414643 chr4:187882934 NA 0.4 7.04 0.36 1.12e-11 Lobe attachment (rater-scored or self-reported); CRC cis rs8031584 0.781 rs4779498 chr15:31177476 C/T cg08109568 chr15:31115862 NA -0.58 -9.2 -0.45 4.09e-18 Huntington's disease progression; CRC cis rs6500602 0.964 rs62039173 chr16:4463846 G/A cg14951292 chr16:4525986 HMOX2;NMRAL1 0.54 7.77 0.39 9.92e-14 Schizophrenia; CRC cis rs7727544 0.660 rs2631361 chr5:131707380 C/A cg07395648 chr5:131743802 NA 0.43 6.66 0.34 1.14e-10 Blood metabolite levels; CRC cis rs1046896 1.000 rs1046875 chr17:80685426 A/G cg19046167 chr17:80928561 B3GNTL1 -0.41 -6.41 -0.33 5e-10 Glycated hemoglobin levels; CRC cis rs7246657 0.943 rs4969487 chr19:37831039 C/T cg23950597 chr19:37808831 NA -0.54 -6.5 -0.34 2.93e-10 Coronary artery calcification; CRC cis rs7586879 0.639 rs3903070 chr2:25123463 C/G cg04586622 chr2:25135609 ADCY3 -0.55 -10.22 -0.49 1.81e-21 Body mass index; CRC cis rs2282802 0.660 rs7726176 chr5:139547971 T/A cg26211634 chr5:139558579 C5orf32 -0.41 -7.13 -0.37 6.3e-12 Intelligence (multi-trait analysis); CRC cis rs4481887 0.504 rs7541625 chr1:248362018 G/C cg00666640 chr1:248458726 OR2T12 0.44 7.07 0.36 9.39e-12 Common traits (Other); CRC cis rs2013441 1.000 rs2526490 chr17:20097526 A/G cg13482628 chr17:19912719 NA -0.4 -6.07 -0.32 3.43e-9 Obesity-related traits; CRC cis rs780096 0.506 rs1647286 chr2:27714517 A/T cg22903471 chr2:27725779 GCKR -0.37 -6.05 -0.32 3.96e-9 Total body bone mineral density; CRC cis rs2576037 1.000 rs2576037 chr18:44585420 C/T cg23996704 chr18:44553084 KATNAL2 0.29 5.66 0.3 3.36e-8 Personality dimensions; CRC cis rs10504229 0.906 rs113857287 chr8:58191683 T/C cg02725872 chr8:58115012 NA -0.37 -6.06 -0.32 3.69e-9 Developmental language disorder (linguistic errors); CRC cis rs734999 0.566 rs6424092 chr1:2532899 C/A cg20673091 chr1:2541236 MMEL1 -0.36 -5.82 -0.31 1.4e-8 Ulcerative colitis; CRC cis rs7786808 0.649 rs6459879 chr7:158211792 C/G cg15440763 chr7:158190612 PTPRN2 0.38 6.28 0.33 1.06e-9 Obesity-related traits; CRC cis rs6582630 0.502 rs1607867 chr12:38385463 C/T cg26384229 chr12:38710491 ALG10B 0.69 9.77 0.47 5.95e-20 Drug-induced liver injury (flucloxacillin); CRC cis rs7586879 0.639 rs6722022 chr2:25098859 A/G cg04586622 chr2:25135609 ADCY3 -0.56 -10.22 -0.49 1.74e-21 Body mass index; CRC cis rs4722166 0.532 rs1546763 chr7:22757843 G/A cg05472934 chr7:22766657 IL6 0.66 10.41 0.5 3.91e-22 Lung cancer; CRC cis rs6503525 0.591 rs8080734 chr17:38103285 G/A cg17467752 chr17:38218738 THRA 0.42 6.19 0.32 1.81e-9 Asthma; CRC cis rs904251 0.772 rs1812186 chr6:37465916 T/C cg01843034 chr6:37503916 NA -0.36 -5.95 -0.31 6.95e-9 Cognitive performance; CRC cis rs9303280 0.901 rs9901146 chr17:38043343 G/A cg00129232 chr17:37814104 STARD3 -0.46 -7.29 -0.37 2.26e-12 Self-reported allergy; CRC cis rs1348850 0.958 rs4893965 chr2:178463852 G/T cg22681709 chr2:178499509 PDE11A -0.33 -6.08 -0.32 3.37e-9 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC trans rs2303319 0.504 rs62189047 chr2:162613314 T/A cg22627826 chr19:1240265 ATP5D -0.72 -6.24 -0.33 1.32e-9 Cognitive function; CRC cis rs1113500 0.933 rs11185260 chr1:108635079 A/T cg06207961 chr1:108661230 NA -0.39 -5.84 -0.31 1.23e-8 Growth-regulated protein alpha levels; CRC cis rs73206853 0.925 rs28670753 chr12:110826463 C/T cg12870014 chr12:110450643 ANKRD13A 0.63 8.09 0.41 1.19e-14 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg27507545 chr10:103880405 LDB1 0.46 6.76 0.35 6.44e-11 Response to antipsychotic treatment; CRC cis rs477692 0.544 rs7923750 chr10:131446895 G/C cg05714579 chr10:131428358 MGMT -0.84 -12.89 -0.58 4.61e-31 Response to temozolomide; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg18436491 chr2:238657876 LRRFIP1 -0.38 -6.62 -0.34 1.45e-10 Liver disease severity in Alagille syndrome; CRC cis rs7618501 0.602 rs2624816 chr3:50117312 T/G cg24110177 chr3:50126178 RBM5 0.52 8.22 0.41 4.72e-15 Intelligence (multi-trait analysis); CRC cis rs6500602 0.634 rs2270365 chr16:4526758 G/A cg14951292 chr16:4525986 HMOX2;NMRAL1 0.56 8.46 0.42 8.98e-16 Schizophrenia; CRC cis rs939574 0.790 rs72955439 chr2:220090804 T/C cg00496455 chr2:220118770 TUBA4A;TUBA4B 0.91 8.43 0.42 1.11e-15 Platelet distribution width; CRC cis rs2011503 1.000 rs34667451 chr19:19617017 C/T cg11584989 chr19:19387371 SF4 0.57 6.39 0.33 5.7e-10 Bipolar disorder; CRC cis rs7044106 0.500 rs56725168 chr9:123492576 T/G cg09419670 chr9:123605666 PSMD5;LOC253039 0.83 14.23 0.62 3.89e-36 Hip circumference adjusted for BMI; CRC cis rs2845885 0.793 rs57779243 chr11:63882363 G/T cg05555928 chr11:63887634 MACROD1 -0.54 -6.42 -0.33 4.89e-10 Body mass index; CRC cis rs853679 0.517 rs9380052 chr6:28064623 A/G cg06470822 chr6:28175283 NA 1.03 13.82 0.61 1.42e-34 Depression; CRC trans rs61931739 0.534 rs2636072 chr12:34062386 C/T cg26384229 chr12:38710491 ALG10B 0.51 6.98 0.36 1.6e-11 Morning vs. evening chronotype; CRC cis rs9814567 1.000 rs11708531 chr3:134224902 T/C cg06541857 chr3:134203789 ANAPC13;CEP63 -0.41 -6.22 -0.32 1.48e-9 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs3733585 0.673 rs6850143 chr4:9958924 T/C cg11266682 chr4:10021025 SLC2A9 -0.47 -9.67 -0.47 1.2e-19 Cleft plate (environmental tobacco smoke interaction); CRC cis rs10193935 0.901 rs13426988 chr2:42604081 G/A cg27598129 chr2:42591480 NA -0.73 -7.31 -0.37 2.08e-12 Colonoscopy-negative controls vs population controls; CRC cis rs9463078 0.809 rs6899845 chr6:45043352 A/C cg25276700 chr6:44698697 NA -0.27 -6.6 -0.34 1.65e-10 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; CRC cis rs7503807 0.967 rs9915162 chr17:78614326 T/C cg09596252 chr17:78655493 RPTOR 0.41 6.41 0.33 5.18e-10 Obesity; CRC cis rs977987 0.778 rs35415181 chr16:75403124 T/C cg03315344 chr16:75512273 CHST6 0.53 8.93 0.44 2.99e-17 Dupuytren's disease; CRC cis rs12908161 1.000 rs35726233 chr15:85337800 C/T cg11189052 chr15:85197271 WDR73 0.57 8.13 0.41 8.8e-15 Schizophrenia; CRC cis rs4481887 0.830 rs10888341 chr1:248441995 T/C cg13385794 chr1:248469461 NA 0.41 7.32 0.37 1.94e-12 Common traits (Other); CRC cis rs6502050 0.835 rs4789668 chr17:80161990 C/T cg02741985 chr17:80059408 CCDC57 0.44 7.28 0.37 2.5e-12 Life satisfaction; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg21629349 chr11:60691880 TMEM132A -0.4 -6.15 -0.32 2.28e-9 Myopia (pathological); CRC cis rs7259376 0.936 rs8111665 chr19:22588559 C/T cg02657401 chr19:22469223 NA 0.31 6.72 0.35 8.02e-11 Menopause (age at onset); CRC trans rs1814175 0.645 rs11040661 chr11:49952146 G/T cg11707556 chr5:10655725 ANKRD33B -0.51 -9.64 -0.47 1.6e-19 Height; CRC cis rs6860806 0.507 rs2631372 chr5:131703578 C/G cg24060327 chr5:131705240 SLC22A5 -0.5 -7.39 -0.38 1.24e-12 Breast cancer; CRC cis rs3106136 0.527 rs2664872 chr4:95146952 G/A cg11021082 chr4:95130006 SMARCAD1 -0.59 -9.46 -0.46 6.05e-19 Capecitabine sensitivity; CRC cis rs5167 0.504 rs3760625 chr19:45456941 G/A cg13119609 chr19:45449297 APOC2 0.31 5.9 0.31 9.2e-9 Blood protein levels; CRC trans rs3942852 0.545 rs10838798 chr11:48091303 T/G cg03929089 chr4:120376271 NA -0.6 -8.31 -0.42 2.59e-15 Acute lymphoblastic leukemia (childhood); CRC cis rs1005277 0.579 rs2474588 chr10:38420870 A/G cg17219203 chr10:38645113 HSD17B7P2 -0.41 -5.76 -0.3 1.92e-8 Extrinsic epigenetic age acceleration; CRC cis rs9527 0.545 rs11191602 chr10:104954219 C/T cg04362960 chr10:104952993 NT5C2 0.61 8.51 0.42 6.45e-16 Arsenic metabolism; CRC cis rs7223966 1.000 rs7214312 chr17:61870863 A/G cg05941027 chr17:61774174 LIMD2 0.35 6.25 0.33 1.27e-9 Hip circumference adjusted for BMI;Body mass index; CRC trans rs17685 0.712 rs1859794 chr7:75821544 G/A cg19862616 chr7:65841803 NCRNA00174 0.96 16.54 0.67 3.79e-45 Coffee consumption;Coffee consumption (cups per day); CRC cis rs10504229 1.000 rs116444534 chr8:58181915 A/G cg05313129 chr8:58192883 C8orf71 -0.45 -6.86 -0.35 3.33e-11 Developmental language disorder (linguistic errors); CRC cis rs67478160 0.643 rs4900600 chr14:104291839 A/G cg01849466 chr14:104193079 ZFYVE21 -0.47 -8.31 -0.42 2.63e-15 Schizophrenia; CRC cis rs55702914 0.746 rs7588530 chr2:198146698 A/C cg20885578 chr2:198174922 NA -0.35 -5.95 -0.31 6.76e-9 Major depression and alcohol dependence; CRC cis rs9287719 0.839 rs12692415 chr2:10745474 A/G cg00105475 chr2:10696890 NA 0.45 7.21 0.37 3.91e-12 Prostate cancer; CRC cis rs10504229 0.906 rs6990615 chr8:58182956 G/A cg24829409 chr8:58192753 C8orf71 -0.68 -11.34 -0.53 2.27e-25 Developmental language disorder (linguistic errors); CRC cis rs2982552 0.805 rs3020345 chr6:152056368 T/G cg22157087 chr6:152012887 ESR1 0.37 5.7 0.3 2.62e-8 Bone properties (heel); CRC cis rs6952808 0.531 rs3779002 chr7:2183219 C/T cg04267008 chr7:1944627 MAD1L1 -0.61 -8.19 -0.41 5.65e-15 Bipolar disorder and schizophrenia; CRC cis rs12476592 0.636 rs196123 chr2:63841712 T/C cg10828910 chr2:63850056 LOC388955 0.53 6.57 0.34 2.02e-10 Childhood ear infection; CRC cis rs10504229 0.683 rs7820302 chr8:58142502 C/T cg02725872 chr8:58115012 NA -0.6 -11.14 -0.52 1.14e-24 Developmental language disorder (linguistic errors); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg21956150 chr19:1438388 RPS15 0.51 8.39 0.42 1.43e-15 Liver disease severity in Alagille syndrome; CRC cis rs2836974 0.644 rs11088471 chr21:40699313 A/G cg17971929 chr21:40555470 PSMG1 -0.63 -9.0 -0.44 1.82e-17 Cognitive function; CRC trans rs2243480 1.000 rs451396 chr7:65484074 T/A cg10756647 chr7:56101905 PSPH 0.77 8.22 0.41 4.72e-15 Diabetic kidney disease; CRC cis rs6912958 0.703 rs6903219 chr6:88096498 G/A cg04972856 chr6:88032051 C6orf162;GJB7 0.33 6.2 0.32 1.73e-9 Monocyte percentage of white cells; CRC cis rs10493773 0.502 rs12061951 chr1:86081453 A/G cg17807903 chr1:86174739 ZNHIT6 -0.46 -8.79 -0.44 8.5e-17 Urate levels in overweight individuals; CRC cis rs2239547 0.603 rs9870898 chr3:53092375 A/G cg10802521 chr3:52805072 NEK4 -0.43 -5.64 -0.3 3.76e-8 Schizophrenia; CRC cis rs11992186 0.597 rs11781841 chr8:8595263 T/A cg06636001 chr8:8085503 FLJ10661 -0.43 -6.05 -0.32 3.97e-9 Neuroticism; CRC cis rs1538970 0.847 rs781230 chr1:45880751 C/T cg05343316 chr1:45956843 TESK2 -0.64 -8.91 -0.44 3.62e-17 Platelet count; CRC cis rs798554 0.679 rs2527677 chr7:2882621 A/G cg19346786 chr7:2764209 NA -0.39 -6.59 -0.34 1.73e-10 Height; CRC cis rs11212617 0.967 rs7127490 chr11:108286758 T/C cg14761454 chr11:108092087 ATM;NPAT 0.39 5.7 0.3 2.71e-8 Response to metformin in type 2 diabetes (glycemic); CRC trans rs1945213 0.694 rs17149976 chr11:55839746 T/C cg03929089 chr4:120376271 NA 0.56 6.35 0.33 7.04e-10 Acute lymphoblastic leukemia (childhood); CRC cis rs6502050 0.697 rs8078634 chr17:80126208 C/T cg25804541 chr17:80189381 SLC16A3 -0.32 -6.01 -0.31 5.03e-9 Life satisfaction; CRC cis rs7523050 0.554 rs34086470 chr1:109485991 C/A cg08274380 chr1:109419600 GPSM2 0.76 6.73 0.35 7.67e-11 Fat distribution (HIV); CRC cis rs7615952 0.611 rs9681518 chr3:125615130 A/G cg05084668 chr3:125655381 ALG1L -0.82 -10.31 -0.49 8.69e-22 Blood pressure (smoking interaction); CRC cis rs7614311 0.689 rs2276863 chr3:63849043 C/A cg22134162 chr3:63841271 THOC7 -0.58 -5.91 -0.31 8.7e-9 Lung function (FVC);Lung function (FEV1); CRC cis rs3858526 0.635 rs2045046 chr11:5875867 A/C cg05234568 chr11:5960015 NA -0.53 -7.0 -0.36 1.44e-11 DNA methylation (variation); CRC cis rs904251 0.620 rs883372 chr6:37477605 A/C cg25019722 chr6:37503610 NA -0.43 -6.17 -0.32 1.97e-9 Cognitive performance; CRC cis rs7615952 0.512 rs11921452 chr3:125359750 A/G cg11143507 chr3:125485238 NA -0.58 -7.46 -0.38 7.69e-13 Blood pressure (smoking interaction); CRC cis rs8049040 0.609 rs11866859 chr16:71478888 G/A cg08717414 chr16:71523259 ZNF19 -0.42 -5.89 -0.31 9.73e-9 Blood protein levels; CRC cis rs17234274 0.607 rs10833974 chr11:23221074 G/C cg05245346 chr11:23248277 NA 0.35 5.75 0.3 2.03e-8 Cancer; CRC cis rs1862618 0.627 rs744023 chr5:56197078 C/T cg03609598 chr5:56110824 MAP3K1 -0.85 -9.27 -0.45 2.59e-18 Initial pursuit acceleration; CRC cis rs1712517 0.588 rs12220267 chr10:105075712 C/T cg04362960 chr10:104952993 NT5C2 -0.47 -6.1 -0.32 2.91e-9 Migraine; CRC cis rs172166 0.637 rs1071893 chr6:28167635 G/C cg21251018 chr6:28226885 NKAPL 0.49 7.72 0.39 1.44e-13 Cardiac Troponin-T levels; CRC cis rs7914558 1.000 rs7067970 chr10:104913870 C/T cg04362960 chr10:104952993 NT5C2 0.59 8.75 0.43 1.14e-16 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs11997175 0.624 rs7819074 chr8:33682472 C/T ch.8.33884649F chr8:33765107 NA 0.43 6.18 0.32 1.88e-9 Body mass index; CRC cis rs908922 0.676 rs4240883 chr1:152526260 C/T cg09873164 chr1:152488093 CRCT1 0.4 6.72 0.35 7.83e-11 Hair morphology; CRC cis rs8180040 0.522 rs749512 chr3:47035900 C/T cg10298567 chr3:47292165 KIF9 0.37 5.62 0.3 4.11e-8 Colorectal cancer; CRC cis rs7131987 0.868 rs7958210 chr12:29395181 G/C cg09582351 chr12:29534625 ERGIC2 -0.3 -6.47 -0.34 3.48e-10 QT interval; CRC cis rs1728785 1.000 rs1182968 chr16:68573945 C/T cg02972257 chr16:68554789 NA -0.58 -7.23 -0.37 3.43e-12 Ulcerative colitis; CRC trans rs916888 0.610 rs199444 chr17:44818276 T/C cg22433210 chr17:43662623 NA 0.63 7.72 0.39 1.45e-13 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs644799 0.965 rs2508713 chr11:95547927 T/A cg25622487 chr11:95524042 FAM76B;CEP57 0.75 11.82 0.55 4.16e-27 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs4481887 1.000 rs7513161 chr1:248453422 A/T cg13385794 chr1:248469461 NA 0.39 6.97 0.36 1.79e-11 Common traits (Other); CRC cis rs11764590 0.950 rs11514731 chr7:2051503 C/G cg13880726 chr7:1868755 MAD1L1 -0.47 -5.68 -0.3 3.01e-8 Neuroticism; CRC cis rs2976388 0.578 rs34956412 chr8:143822028 C/T cg24634471 chr8:143751801 JRK -0.5 -6.77 -0.35 5.9e-11 Urinary tract infection frequency; CRC cis rs4319547 0.774 rs7307233 chr12:123124301 C/G cg05707623 chr12:122985044 ZCCHC8 -0.63 -8.13 -0.41 9.1e-15 Body mass index; CRC cis rs1552244 1.000 rs113522867 chr3:10154503 T/C cg00166722 chr3:10149974 C3orf24 0.7 9.17 0.45 5.23e-18 Alzheimer's disease; CRC trans rs1360141 1.000 rs1360141 chr9:74292016 C/G cg07994661 chr4:153856847 NA -0.33 -6.15 -0.32 2.21e-9 Acute graft versus host disease in bone marrow transplantation (recipient effect); CRC trans rs4263408 0.934 rs9683743 chr4:39703194 A/C cg14700821 chr5:64777802 ADAMTS6 -0.41 -5.99 -0.31 5.39e-9 Plasma amyloid beta peptide concentrations (ABx-40); CRC cis rs10504229 0.683 rs61201557 chr8:58138370 T/C cg24829409 chr8:58192753 C8orf71 -0.55 -8.03 -0.4 1.71e-14 Developmental language disorder (linguistic errors); CRC cis rs9660992 0.700 rs7547565 chr1:205259402 G/A cg21643547 chr1:205240462 TMCC2 0.47 7.91 0.4 3.9e-14 Mean corpuscular volume;Mean platelet volume; CRC cis rs9902453 0.904 rs10853136 chr17:28406018 C/T cg26525008 chr17:28256777 EFCAB5;SSH2 -0.69 -11.43 -0.53 1.06e-25 Coffee consumption (cups per day); CRC cis rs6963495 0.519 rs3892297 chr7:105152173 G/A cg13798780 chr7:105162888 PUS7 0.67 7.78 0.39 9.18e-14 Bipolar disorder (body mass index interaction); CRC cis rs7147624 0.683 rs8017258 chr14:66231017 C/G cg03016385 chr14:66212404 NA 0.77 6.76 0.35 6.42e-11 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs13082711 0.554 rs73055724 chr3:27380397 T/G cg02860705 chr3:27208620 NA 0.85 10.9 0.52 7.9e-24 Systolic blood pressure;Diastolic blood pressure;Blood pressure; CRC cis rs8077889 0.956 rs4793025 chr17:41841621 T/C cg16892393 chr17:41919603 NA 0.51 7.09 0.36 8.33e-12 Triglycerides; CRC cis rs66573146 0.803 rs60228659 chr4:7031704 G/A cg00086871 chr4:6988644 TBC1D14 0.81 6.14 0.32 2.39e-9 Granulocyte percentage of myeloid white cells; CRC cis rs9322193 0.923 rs9689599 chr6:149953109 A/C cg05861140 chr6:150128134 PCMT1 -0.36 -5.92 -0.31 8.26e-9 Lung cancer; CRC cis rs12497850 0.931 rs13316620 chr3:49045355 T/C cg07636037 chr3:49044803 WDR6 1.04 18.42 0.71 1.46e-52 Parkinson's disease; CRC cis rs873946 0.586 rs3793685 chr10:134569316 G/A cg26818010 chr10:134567672 INPP5A -0.71 -9.2 -0.45 4.39e-18 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CRC cis rs12701220 0.655 rs7778968 chr7:1144622 C/G cg26240231 chr7:1148101 C7orf50 -0.47 -6.85 -0.35 3.68e-11 Bronchopulmonary dysplasia; CRC trans rs2228479 0.850 rs62052212 chr16:89981960 G/A cg21302420 chr1:112162376 RAP1A 0.7 6.29 0.33 1.01e-9 Skin colour saturation; CRC cis rs2455601 0.638 rs2742478 chr11:8996099 G/C cg09997546 chr11:8931473 C11orf17;ST5 -0.44 -6.03 -0.32 4.44e-9 Schizophrenia; CRC cis rs60843830 0.661 rs55987018 chr2:106655 C/T cg00108164 chr2:264199 ACP1;SH3YL1 0.42 5.77 0.3 1.83e-8 Spherical equivalent (joint analysis main effects and education interaction); CRC cis rs1862618 0.802 rs33327 chr5:56142693 T/G cg20203395 chr5:56204925 C5orf35 -0.72 -8.55 -0.43 4.67e-16 Initial pursuit acceleration; CRC trans rs274508 0.926 rs905620 chr11:11102017 C/T cg18158151 chr2:61372256 C2orf74 0.31 5.98 0.31 5.69e-9 Knee osteoarthritis; CRC cis rs10504229 0.683 rs72649187 chr8:58108320 A/G cg02290350 chr8:58132656 NA -0.59 -8.03 -0.4 1.7e-14 Developmental language disorder (linguistic errors); CRC cis rs883565 0.655 rs6777651 chr3:39143599 G/C cg01426195 chr3:39028469 NA -0.54 -8.61 -0.43 3.02e-16 Handedness; CRC cis rs2398893 0.774 rs35888804 chr9:96887153 T/C cg14459158 chr9:96720562 NA 0.45 6.42 0.33 4.79e-10 Waist-hip ratio;Waist-to-hip ratio adjusted for body mass index; CRC cis rs4713118 0.662 rs9468271 chr6:28024570 A/G cg02683197 chr6:28174875 NA 0.75 9.84 0.48 3.43e-20 Parkinson's disease; CRC cis rs2268241 0.938 rs9974603 chr21:34776300 C/A cg14850771 chr21:34775459 IFNGR2 0.8 10.5 0.5 1.9e-22 Obesity-related traits; CRC cis rs7707921 0.767 rs862244 chr5:81586801 G/A cg07807695 chr5:81608485 ATP6AP1L -0.47 -7.4 -0.38 1.14e-12 Breast cancer; CRC trans rs11039798 0.512 rs11040205 chr11:49007360 G/C cg03929089 chr4:120376271 NA 0.64 6.47 0.34 3.62e-10 Axial length; CRC cis rs172166 0.538 rs1150686 chr6:28161271 T/G cg15786705 chr6:28176104 NA 0.48 7.16 0.37 5.19e-12 Cardiac Troponin-T levels; CRC cis rs7762018 1.000 rs4716378 chr6:170086568 G/C cg19338460 chr6:170058176 WDR27 -0.75 -8.14 -0.41 8.03e-15 Thiazide-induced adverse metabolic effects in hypertensive patients; CRC cis rs10504229 0.683 rs7816733 chr8:58129855 G/A cg05313129 chr8:58192883 C8orf71 -0.43 -6.11 -0.32 2.74e-9 Developmental language disorder (linguistic errors); CRC cis rs67478160 0.643 rs876002 chr14:104239697 G/A cg08213375 chr14:104286397 PPP1R13B 0.65 13.66 0.6 6.03e-34 Schizophrenia; CRC trans rs9784649 1.000 rs3933895 chr5:25004929 A/T cg08600765 chr20:34638493 LOC647979 -0.55 -6.12 -0.32 2.71e-9 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs3820068 0.581 rs16851841 chr1:15922713 A/G cg13390004 chr1:15929781 NA 0.49 7.0 0.36 1.45e-11 Systolic blood pressure; CRC cis rs919433 0.929 rs10931779 chr2:198166825 A/G cg20885578 chr2:198174922 NA -0.39 -7.21 -0.37 3.93e-12 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg23055938 chr1:160991191 F11R 0.39 6.0 0.31 5.12e-9 Liver disease severity in Alagille syndrome; CRC cis rs11098499 0.789 rs1980024 chr4:120253047 C/T cg24375607 chr4:120327624 NA 0.47 7.6 0.39 3.06e-13 Corneal astigmatism; CRC cis rs12142240 0.698 rs10158236 chr1:46820896 G/T cg14993813 chr1:46806288 NSUN4 -0.49 -6.22 -0.32 1.55e-9 Menopause (age at onset); CRC cis rs71403859 0.570 rs76231867 chr16:71449926 G/A cg08717414 chr16:71523259 ZNF19 -0.72 -7.92 -0.4 3.79e-14 Post bronchodilator FEV1; CRC cis rs9296092 0.522 rs62405955 chr6:33527176 T/C cg13560919 chr6:33536144 NA -0.44 -6.28 -0.33 1.09e-9 Age at smoking initiation in chronic obstructive pulmonary disease; CRC cis rs1577917 0.958 rs12195776 chr6:86488599 C/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.52 -6.92 -0.36 2.4e-11 Response to antipsychotic treatment; CRC cis rs9916302 0.861 rs644173 chr17:37430519 T/C cg00129232 chr17:37814104 STARD3 -0.56 -8.22 -0.41 4.69e-15 Glomerular filtration rate (creatinine); CRC cis rs2635047 0.638 rs2668758 chr18:44685679 A/C cg19077165 chr18:44547161 KATNAL2 -0.43 -6.83 -0.35 4.03e-11 Educational attainment; CRC cis rs6424115 0.830 rs3003336 chr1:24201448 C/T cg15997130 chr1:24165203 NA 0.73 10.74 0.51 2.79e-23 Immature fraction of reticulocytes; CRC trans rs860818 1.000 rs858303 chr7:23243498 C/G cg07869405 chr10:1444797 ADARB2 0.69 6.33 0.33 8.14e-10 Initial pursuit acceleration; CRC cis rs736408 0.507 rs6445531 chr3:52717282 T/C cg10802521 chr3:52805072 NEK4 -0.58 -9.08 -0.45 1.05e-17 Bipolar disorder; CRC cis rs12477438 0.520 rs11692699 chr2:99730657 T/C cg26064155 chr2:99771622 LIPT1;TSGA10 0.88 16.22 0.67 6.67e-44 Chronic sinus infection; CRC cis rs2688608 0.839 rs2675662 chr10:75599127 A/G cg00564723 chr10:75632066 CAMK2G 0.23 5.79 0.3 1.61e-8 Inflammatory bowel disease; CRC cis rs270601 0.690 rs162907 chr5:131580152 A/G cg20512303 chr5:131592959 PDLIM4 -0.4 -7.13 -0.37 6.55e-12 Acylcarnitine levels; CRC cis rs79839061 0.610 rs12651271 chr4:854071 C/T cg07828340 chr4:882639 GAK 1.12 10.98 0.52 4.12e-24 Intelligence (multi-trait analysis); CRC cis rs4665809 0.567 rs12999875 chr2:26414847 A/C cg25036284 chr2:26402008 FAM59B 0.61 7.74 0.39 1.27e-13 Gut microbiome composition (summer); CRC cis rs1670533 1.000 rs629260 chr4:1086764 A/G cg27284194 chr4:1044797 NA 0.5 6.33 0.33 7.9e-10 Recombination rate (females); CRC cis rs7618915 0.571 rs11130307 chr3:52607682 G/A cg18404041 chr3:52824283 ITIH1 -0.44 -9.05 -0.45 1.29e-17 Bipolar disorder; CRC cis rs11758351 0.778 rs41266801 chr6:26197493 C/A cg01420254 chr6:26195488 NA 0.84 8.75 0.43 1.11e-16 Gout;Renal underexcretion gout; CRC cis rs9287719 0.934 rs4629131 chr2:10744159 C/T cg00105475 chr2:10696890 NA 0.45 7.3 0.37 2.2e-12 Prostate cancer; CRC cis rs17376456 0.825 rs34592268 chr5:93232751 G/C cg09848695 chr5:92956644 FAM172A;MIR2277 0.66 6.03 0.32 4.49e-9 Diabetic retinopathy; CRC cis rs34779708 0.897 rs4934529 chr10:35302376 T/A cg03585969 chr10:35415529 CREM 0.67 8.91 0.44 3.47e-17 Inflammatory bowel disease;Crohn's disease; CRC cis rs9611565 0.512 rs2050031 chr22:42152266 A/G cg06634786 chr22:41940651 POLR3H 0.66 7.29 0.37 2.28e-12 Vitiligo; CRC cis rs10504229 0.728 rs17804624 chr8:58154216 T/C cg21724239 chr8:58056113 NA 0.62 8.38 0.42 1.51e-15 Developmental language disorder (linguistic errors); CRC cis rs9916302 0.718 rs7219909 chr17:37706243 C/T cg07936489 chr17:37558343 FBXL20 -0.86 -13.78 -0.6 2.1e-34 Glomerular filtration rate (creatinine); CRC trans rs2303319 0.504 rs35304298 chr2:162617185 G/T cg18122310 chr12:50236657 BCDIN3D -0.73 -6.35 -0.33 7.23e-10 Cognitive function; CRC cis rs35264875 1.000 rs72928636 chr11:68848386 C/T cg01993067 chr11:68851601 TPCN2 0.56 6.33 0.33 7.99e-10 Blond vs. brown hair color; CRC cis rs477895 0.653 rs34113693 chr11:63900123 G/T cg23719950 chr11:63933701 MACROD1 -0.65 -8.25 -0.41 3.82e-15 Mean platelet volume; CRC cis rs4561483 0.832 rs33645 chr16:11985201 T/C cg08843971 chr16:11963173 GSPT1 -0.62 -9.57 -0.47 2.66e-19 Testicular germ cell tumor; CRC trans rs561341 1.000 rs55962687 chr17:30260369 C/T cg20587970 chr11:113659929 NA -1.39 -18.95 -0.72 1.2e-54 Hip circumference adjusted for BMI; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg10698222 chr7:99756139 C7orf43 0.42 6.79 0.35 5.39e-11 Liver disease severity in Alagille syndrome; CRC cis rs7618915 0.547 rs2164884 chr3:52629633 C/T cg07507251 chr3:52567010 NT5DC2 0.42 5.98 0.31 5.82e-9 Bipolar disorder; CRC cis rs9942416 0.660 rs111937612 chr5:74979631 C/T cg00601450 chr5:74908170 NA 0.41 5.77 0.3 1.84e-8 Age-related disease endophenotypes; CRC cis rs5769707 0.632 rs135876 chr22:50013573 A/G cg20744362 chr22:50050164 C22orf34 0.35 6.24 0.33 1.37e-9 Monocyte count;Monocyte percentage of white cells; CRC cis rs6541297 1.000 rs4846839 chr1:230284924 A/G cg20703242 chr1:230279135 GALNT2 0.53 7.94 0.4 3.33e-14 Coronary artery disease; CRC cis rs35110281 0.720 rs162393 chr21:44942692 G/A cg01579765 chr21:45077557 HSF2BP -0.37 -7.0 -0.36 1.42e-11 Mean corpuscular volume; CRC cis rs2019137 0.936 rs4849169 chr2:113953657 A/C cg21550016 chr2:113992930 PAX8;LOC440839;LOC654433 -0.52 -7.42 -0.38 1e-12 Lymphocyte counts; CRC cis rs367943 1.000 rs348961 chr5:112819944 A/C cg12552261 chr5:112820674 MCC -0.56 -7.43 -0.38 9.49e-13 Type 2 diabetes; CRC cis rs57221529 0.766 rs4081847 chr5:574072 C/T cg16447950 chr5:562315 NA -0.78 -10.46 -0.5 2.71e-22 Lung disease severity in cystic fibrosis; CRC cis rs863345 0.526 rs2051067 chr1:158507398 G/T cg12129480 chr1:158549410 OR10X1 -0.3 -6.27 -0.33 1.12e-9 Pneumococcal bacteremia; CRC trans rs4843747 0.573 rs7499959 chr16:88110422 C/G cg26811252 chr16:29126840 RRN3P2 0.53 7.26 0.37 2.75e-12 Menopause (age at onset); CRC cis rs7777484 0.534 rs2533886 chr7:2834869 C/T cg19717773 chr7:2847554 GNA12 -0.49 -8.72 -0.43 1.45e-16 Height; CRC cis rs7107174 1.000 rs2510050 chr11:77982564 A/G cg02023728 chr11:77925099 USP35 0.53 7.86 0.4 5.46e-14 Testicular germ cell tumor; CRC cis rs16924133 0.793 rs58772662 chr11:33141020 C/A cg05567920 chr11:33183001 CSTF3 -0.77 -5.77 -0.3 1.81e-8 Anger; CRC cis rs1957429 0.808 rs1570296 chr14:65332294 T/A cg23373153 chr14:65346875 NA 0.66 6.74 0.35 7.01e-11 Pediatric areal bone mineral density (radius); CRC cis rs7818382 0.967 rs7812465 chr8:96050557 C/T cg23172400 chr8:95962367 TP53INP1 0.48 7.91 0.4 4.08e-14 Alzheimer's disease (late onset); CRC cis rs5753618 0.539 rs2228619 chr22:31663842 C/G cg22777020 chr22:31556080 RNF185 -0.53 -6.03 -0.32 4.47e-9 Colorectal cancer; CRC cis rs7072216 0.652 rs11189600 chr10:100179274 A/G cg26618903 chr10:100175079 PYROXD2 0.39 6.52 0.34 2.66e-10 Metabolite levels; CRC cis rs16924133 1.000 rs12293487 chr11:33166176 A/C cg05567920 chr11:33183001 CSTF3 -0.78 -5.92 -0.31 7.95e-9 Anger; CRC cis rs832540 0.830 rs252907 chr5:56120646 G/A cg24531977 chr5:56204891 C5orf35 -0.45 -6.91 -0.36 2.48e-11 Coronary artery disease; CRC cis rs2898681 0.739 rs8287 chr4:53732586 T/C cg00338735 chr4:53728038 RASL11B 0.39 6.1 0.32 2.91e-9 Optic nerve measurement (cup area); CRC trans rs1455244 0.700 rs7229302 chr18:11508904 G/T cg21389884 chr11:119599425 PVRL1 0.39 5.98 0.31 5.73e-9 Schizophrenia; CRC cis rs4820539 0.708 rs5751591 chr22:23489042 G/A cg14186256 chr22:23484241 RTDR1 0.78 13.12 0.59 6.58e-32 Bone mineral density; CRC cis rs72634258 0.838 rs10489450 chr1:8079301 C/T cg26816564 chr1:7831052 VAMP3 0.54 6.07 0.32 3.48e-9 Inflammatory bowel disease; CRC cis rs4862750 0.872 rs6553029 chr4:187876470 G/T cg06074448 chr4:187884817 NA 0.57 10.49 0.5 2.06e-22 Lobe attachment (rater-scored or self-reported); CRC cis rs9549328 0.800 rs9549616 chr13:113627762 T/G cg17524180 chr13:113633600 MCF2L -0.68 -12.79 -0.58 1.13e-30 Systolic blood pressure; CRC cis rs9916302 0.904 rs755500 chr17:37409865 C/T cg03013999 chr17:37608204 MED1 0.46 7.08 0.36 8.74e-12 Glomerular filtration rate (creatinine); CRC cis rs7618915 0.501 rs11714030 chr3:52765882 C/T cg11645453 chr3:52864694 ITIH4 0.36 6.51 0.34 2.87e-10 Bipolar disorder; CRC cis rs2180341 1.000 rs4897207 chr6:127605898 C/T cg24812749 chr6:127587940 RNF146 0.94 13.67 0.6 5.36e-34 Breast cancer; CRC trans rs7302981 0.746 rs836177 chr12:50491821 A/G cg18430156 chr2:187558795 FAM171B -0.37 -6.25 -0.33 1.27e-9 Systolic blood pressure; CRC cis rs1143633 0.530 rs2723163 chr2:113694339 A/G cg06156847 chr2:113672199 IL1F7 -0.45 -6.9 -0.36 2.66e-11 Allergic disease (asthma, hay fever or eczema); CRC cis rs8060686 0.516 rs9938020 chr16:68251784 C/G cg26727032 chr16:67993705 SLC12A4 -0.61 -9.02 -0.45 1.54e-17 HDL cholesterol;Metabolic syndrome; CRC cis rs55871839 0.708 rs4738735 chr8:59816985 T/C cg07426533 chr8:59803705 TOX -0.34 -5.82 -0.31 1.37e-8 Pneumonia; CRC cis rs1552244 1.000 rs4269070 chr3:10126083 C/G cg16606324 chr3:10149918 C3orf24 0.71 9.83 0.48 3.77e-20 Alzheimer's disease; CRC cis rs9902453 1.000 rs9897206 chr17:28406108 C/T cg26525008 chr17:28256777 EFCAB5;SSH2 -0.58 -8.82 -0.44 6.74e-17 Coffee consumption (cups per day); CRC cis rs6424115 0.862 rs34845821 chr1:24066486 C/T cg08896387 chr1:24191740 FUCA1 0.47 5.85 0.31 1.19e-8 Immature fraction of reticulocytes; CRC trans rs2303319 0.504 rs72877343 chr2:162607487 A/C cg03774468 chr3:140950104 ACPL2 -0.65 -6.07 -0.32 3.61e-9 Cognitive function; CRC cis rs853679 0.527 rs853693 chr6:28282648 C/T cg06470822 chr6:28175283 NA 0.49 6.9 0.36 2.68e-11 Depression; CRC cis rs1451375 0.583 rs3779078 chr7:50610918 C/T cg14593290 chr7:50529359 DDC 0.67 8.83 0.44 6.24e-17 Malaria; CRC cis rs10089 1.000 rs9968597 chr5:127455383 C/G cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.76 10.8 0.51 1.74e-23 Ileal carcinoids; CRC cis rs12188164 0.543 rs2434695 chr5:464177 C/G cg26850624 chr5:429559 AHRR 0.54 9.03 0.45 1.46e-17 Cystic fibrosis severity; CRC cis rs6963495 0.818 rs73190186 chr7:105164368 G/C cg13798780 chr7:105162888 PUS7 0.68 8.08 0.41 1.27e-14 Bipolar disorder (body mass index interaction); CRC cis rs1218582 0.596 rs906595 chr1:154822907 C/T cg24250549 chr1:154909240 PMVK 0.44 6.38 0.33 6.05e-10 Prostate cancer; CRC cis rs4713118 0.662 rs149946 chr6:27970031 A/C cg06470822 chr6:28175283 NA -0.89 -13.18 -0.59 3.94e-32 Parkinson's disease; CRC cis rs3096299 0.685 rs8050512 chr16:89552320 C/G cg01788221 chr16:89496183 ANKRD11 -0.38 -5.67 -0.3 3.12e-8 Multiple myeloma (IgH translocation); CRC cis rs3736485 0.934 rs11635216 chr15:51871947 A/G cg08986416 chr15:51914746 DMXL2 0.46 6.56 0.34 2.07e-10 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs9322193 0.923 rs12526675 chr6:150050676 A/C cg00933542 chr6:150070202 PCMT1 -0.31 -6.25 -0.33 1.3e-9 Lung cancer; CRC cis rs853679 0.517 rs4713152 chr6:28137454 G/A cg12963246 chr6:28129442 ZNF389 0.49 5.7 0.3 2.71e-8 Depression; CRC trans rs951252 0.504 rs11734405 chr4:146081096 C/T cg12614029 chr11:2160564 INS-IGF2;IGF2AS;IGF2 0.37 6.65 0.34 1.26e-10 Hip circumference; CRC cis rs483180 0.859 rs478093 chr1:120255126 C/T cg19096424 chr1:120255104 PHGDH -0.54 -7.34 -0.37 1.73e-12 Macular telangiectasia type 2; CRC cis rs9916302 0.752 rs6503513 chr17:37561613 A/G cg07936489 chr17:37558343 FBXL20 0.97 14.66 0.63 8.09e-38 Glomerular filtration rate (creatinine); CRC cis rs7312933 0.558 rs4768402 chr12:42755576 A/G cg19980929 chr12:42632907 YAF2 -0.39 -5.89 -0.31 9.49e-9 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CRC trans rs10983614 1.000 rs7867776 chr9:120072627 A/G cg09239099 chr12:1100377 ERC1 0.43 6.11 0.32 2.75e-9 Survival in pancreatic cancer; CRC trans rs3931020 0.720 rs927904 chr1:75260328 A/G cg11942470 chr9:86594803 HNRNPK;RMI1 0.48 6.13 0.32 2.57e-9 Resistin levels; CRC cis rs736408 0.546 rs3733046 chr3:52621627 C/T cg15147215 chr3:52552868 STAB1 -0.63 -10.81 -0.51 1.69e-23 Bipolar disorder; CRC cis rs7937682 0.924 rs10891288 chr11:111552053 G/T cg19812747 chr11:111475976 SIK2 0.55 9.33 0.46 1.58e-18 Primary sclerosing cholangitis; CRC trans rs11764590 0.694 rs4721321 chr7:2068470 A/G cg11693508 chr17:37793320 STARD3 0.46 6.17 0.32 2e-9 Neuroticism; CRC cis rs10927875 0.691 rs1048302 chr1:16340879 T/G cg22431228 chr1:16359049 CLCNKA -0.43 -7.46 -0.38 7.9e-13 Dilated cardiomyopathy; CRC cis rs7178572 0.625 rs12905285 chr15:77845812 T/C cg22256960 chr15:77711686 NA -0.54 -8.17 -0.41 6.7e-15 Type 2 diabetes; CRC cis rs1729951 0.575 rs747842 chr3:136703121 A/C cg21827317 chr3:136751795 NA 0.35 5.81 0.31 1.44e-8 Neuroticism; CRC cis rs8180040 0.966 rs11707895 chr3:47574937 G/A cg27129171 chr3:47204927 SETD2 -0.63 -9.6 -0.47 2.19e-19 Colorectal cancer; CRC trans rs7613875 0.600 rs1061474 chr3:50144951 T/C cg21659725 chr3:3221576 CRBN -0.44 -6.35 -0.33 7.19e-10 Body mass index; CRC cis rs10751667 0.643 rs7395592 chr11:934094 C/G cg23136738 chr11:925521 AP2A2 -0.42 -6.84 -0.35 3.78e-11 Alzheimer's disease (late onset); CRC cis rs4478858 0.684 rs2271074 chr1:31734841 C/T cg00250761 chr1:31883323 NA -0.45 -8.8 -0.44 8.05e-17 Alcohol dependence; CRC cis rs12586317 0.620 rs10145433 chr14:35583333 G/A cg16230307 chr14:35515116 FAM177A1 0.78 9.36 0.46 1.29e-18 Psoriasis; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg05598539 chr7:128695331 TNPO3;LOC286016 0.48 6.78 0.35 5.75e-11 Response to antipsychotic treatment; CRC cis rs7666738 0.753 rs35194639 chr4:99053819 G/C cg17366294 chr4:99064904 C4orf37 0.45 7.71 0.39 1.46e-13 Colonoscopy-negative controls vs population controls; CRC trans rs3845702 0.736 rs115569960 chr2:180848214 C/T cg25411327 chr19:5210703 PTPRS -0.59 -6.11 -0.32 2.76e-9 Schizophrenia; CRC trans rs11098499 0.542 rs10440343 chr4:120309787 G/C cg25214090 chr10:38739885 LOC399744 0.62 9.74 0.47 7.35e-20 Corneal astigmatism; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg10047026 chr17:4613992 ARRB2 0.41 6.87 0.35 3.29e-11 Liver disease severity in Alagille syndrome; CRC cis rs4660214 0.666 rs11205739 chr1:39656401 G/A cg11070191 chr1:39582205 MACF1 0.36 5.76 0.3 1.9e-8 Peripheral arterial disease (traffic-related air pollution interaction); CRC trans rs6897795 0.680 rs9329133 chr5:177609540 C/T cg19598605 chr2:70056955 GMCL1 -0.67 -8.61 -0.43 3.09e-16 Plateletcrit; CRC cis rs919433 0.963 rs10153881 chr2:198171098 T/C cg03934865 chr2:198174659 NA -0.43 -6.92 -0.36 2.44e-11 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC cis rs881375 0.678 rs10760125 chr9:123662590 G/A cg09586646 chr9:123605570 PSMD5;LOC253039 0.46 6.84 0.35 3.88e-11 Rheumatoid arthritis; CRC cis rs9787249 1.000 rs9787249 chr1:40212878 G/A cg24920358 chr1:40204285 PPIE 0.57 8.66 0.43 2.14e-16 Blood protein levels; CRC cis rs12545109 0.800 rs2582401 chr8:57401656 A/G cg09654669 chr8:57350985 NA -0.41 -5.8 -0.3 1.59e-8 Obesity-related traits; CRC cis rs2721195 0.874 rs2721173 chr8:145744429 C/T cg11211951 chr8:145729740 GPT 0.46 8.53 0.43 5.38e-16 Age at first birth; CRC cis rs7487075 0.786 rs4768110 chr12:46677461 G/A cg22049899 chr12:47219821 SLC38A4 0.32 6.11 0.32 2.84e-9 Itch intensity from mosquito bite; CRC cis rs9969804 0.905 rs7864757 chr9:95399865 T/C cg14631576 chr9:95140430 CENPP -0.31 -5.67 -0.3 3.1e-8 Height; CRC cis rs801193 0.548 rs6975044 chr7:66227482 C/T cg00343986 chr7:65444356 GUSB 0.42 5.76 0.3 1.94e-8 Aortic root size; CRC cis rs7666738 0.830 rs6839277 chr4:99015563 C/T cg17366294 chr4:99064904 C4orf37 0.44 7.35 0.38 1.55e-12 Colonoscopy-negative controls vs population controls; CRC cis rs12477438 1.000 rs6542873 chr2:99824965 C/T cg26064155 chr2:99771622 LIPT1;TSGA10 -0.65 -7.96 -0.4 2.76e-14 Chronic sinus infection; CRC cis rs873946 0.648 rs35417213 chr10:134553749 A/G cg18305652 chr10:134549665 INPP5A 0.5 6.49 0.34 3.13e-10 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CRC cis rs9322193 0.962 rs9397022 chr6:150133188 C/T cg13206674 chr6:150067644 NUP43 0.54 7.66 0.39 2.09e-13 Lung cancer; CRC cis rs1046896 0.561 rs8076476 chr17:80861017 A/C cg17346650 chr17:80929145 B3GNTL1 0.46 6.7 0.35 8.9e-11 Glycated hemoglobin levels; CRC cis rs501120 1.000 rs605445 chr10:44756779 C/T cg09554077 chr10:44749378 NA 0.78 12.0 0.55 9.18e-28 Coronary artery disease;Coronary heart disease; CRC cis rs11122272 0.668 rs2808616 chr1:231554993 C/G cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX 0.59 9.13 0.45 7.01e-18 Hemoglobin concentration; CRC cis rs9611519 0.964 rs4820428 chr22:41537589 C/T cg03806693 chr22:41940476 POLR3H 0.54 6.85 0.35 3.58e-11 Neuroticism; CRC trans rs2303319 0.504 rs12470590 chr2:162493102 A/G cg25193742 chr10:104614220 C10orf32 -0.72 -5.97 -0.31 6.32e-9 Cognitive function; CRC cis rs79976124 0.879 rs12213669 chr6:66627704 G/A cg07460842 chr6:66804631 NA 0.76 9.41 0.46 8.96e-19 Type 2 diabetes; CRC cis rs3733585 0.699 rs28837683 chr4:9959808 C/T cg11266682 chr4:10021025 SLC2A9 -0.48 -9.86 -0.48 2.88e-20 Cleft plate (environmental tobacco smoke interaction); CRC cis rs12824058 0.831 rs4759653 chr12:130812604 T/C cg24838063 chr12:130822603 PIWIL1 0.58 9.76 0.47 6.18e-20 Menopause (age at onset); CRC cis rs875971 0.862 rs778697 chr7:65870426 G/A cg00343986 chr7:65444356 GUSB 0.45 6.22 0.32 1.52e-9 Aortic root size; CRC cis rs1707322 1.000 rs11211228 chr1:46399840 G/A cg06784218 chr1:46089804 CCDC17 0.51 9.02 0.45 1.57e-17 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC trans rs4325129 0.513 rs35393723 chr1:159505101 G/A cg26466145 chr3:188665930 NA -0.42 -6.52 -0.34 2.69e-10 Obesity-related traits; CRC cis rs6557786 0.636 rs17052934 chr8:24840319 A/C cg20585869 chr8:24772333 NEFM -0.38 -6.51 -0.34 2.86e-10 Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 2 peripheral neuropathy); CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg17608500 chr1:154955711 FLAD1 0.55 7.27 0.37 2.69e-12 Thyroid stimulating hormone; CRC cis rs7567389 0.740 rs4536600 chr2:128002572 A/G cg09760422 chr2:128146352 NA 0.38 7.41 0.38 1.07e-12 Self-rated health; CRC cis rs4604732 0.574 rs111928142 chr1:247625229 G/T cg12754571 chr1:247694271 LOC148824;OR2C3 0.42 5.78 0.3 1.71e-8 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CRC cis rs13108904 0.967 rs11727167 chr4:1285521 A/G cg21620606 chr4:1342894 KIAA1530 0.35 5.75 0.3 2.04e-8 Obesity-related traits; CRC cis rs6951245 1.000 rs75488469 chr7:1102122 A/G cg24642844 chr7:1081250 C7orf50 -0.75 -9.07 -0.45 1.12e-17 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs10876993 0.855 rs1689585 chr12:58080140 A/G cg15848620 chr12:58087721 OS9 0.58 8.09 0.41 1.12e-14 Celiac disease or Rheumatoid arthritis; CRC cis rs1707322 0.638 rs9429095 chr1:46603348 A/C cg06784218 chr1:46089804 CCDC17 -0.49 -7.78 -0.39 9.37e-14 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs11758351 0.866 rs11757394 chr6:26206694 G/C cg22723502 chr6:26240528 HIST1H4F -0.39 -6.33 -0.33 8.03e-10 Gout;Renal underexcretion gout; CRC cis rs11971779 0.616 rs6965143 chr7:139026608 C/G cg07862535 chr7:139043722 LUC7L2 0.54 7.05 0.36 1.09e-11 Diisocyanate-induced asthma; CRC cis rs6951245 0.572 rs79396675 chr7:1055047 C/T cg20603222 chr7:1096387 C7orf50;GPR146 -0.73 -6.0 -0.31 5.2e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg19182353 chr11:118479428 PHLDB1 -0.42 -6.39 -0.33 5.61e-10 Liver disease severity in Alagille syndrome; CRC cis rs11948739 0.610 rs2419754 chr5:130252688 T/C cg08523029 chr5:130500466 HINT1 0.49 6.26 0.33 1.19e-9 Pediatric bone mineral content (hip); CRC cis rs891088 0.677 rs11670960 chr19:7185504 C/T cg09779027 chr19:7224513 INSR -0.59 -6.08 -0.32 3.32e-9 Hip circumference adjusted for BMI;Height; CRC cis rs8062405 0.824 rs4788084 chr16:28539848 C/T cg16576597 chr16:28551801 NUPR1 0.47 7.34 0.37 1.74e-12 Cognitive ability (multi-trait analysis);Cognitive ability; CRC cis rs11190604 1.000 rs2495739 chr10:102335507 C/T cg16342193 chr10:102329863 NA -0.37 -6.19 -0.32 1.8e-9 Palmitoleic acid (16:1n-7) levels; CRC cis rs2982552 0.873 rs977532 chr6:152068883 C/T cg22157087 chr6:152012887 ESR1 0.37 5.68 0.3 3.01e-8 Bone properties (heel); CRC cis rs1150668 0.796 rs2531825 chr6:28349264 C/T cg03623178 chr6:28175578 NA 0.48 7.06 0.36 9.9e-12 Pubertal anthropometrics; CRC cis rs8062405 0.755 rs12447461 chr16:28582941 C/A cg05139728 chr16:28306816 SBK1 -0.38 -6.23 -0.32 1.41e-9 Cognitive ability (multi-trait analysis);Cognitive ability; CRC cis rs12137294 0.761 rs1172150 chr1:205221861 A/G cg24159697 chr1:205181237 DSTYK -0.34 -6.08 -0.32 3.29e-9 Red cell distribution width; CRC cis rs7044106 0.762 rs1470307 chr9:123433039 A/G cg09419670 chr9:123605666 PSMD5;LOC253039 0.7 11.33 0.53 2.41e-25 Hip circumference adjusted for BMI; CRC cis rs2836950 0.545 rs8132424 chr21:40584412 A/T cg06238570 chr21:40685208 BRWD1 0.62 9.1 0.45 8.57e-18 Menarche (age at onset); CRC cis rs2952156 0.920 rs9303274 chr17:37836353 T/C cg20243544 chr17:37824526 PNMT 0.56 9.05 0.45 1.3e-17 Asthma; CRC cis rs4665809 0.590 rs3806515 chr2:26466975 C/T cg25036284 chr2:26402008 FAM59B 0.61 7.76 0.39 1.09e-13 Gut microbiome composition (summer); CRC cis rs2011503 1.000 rs2916072 chr19:19525712 G/A cg11584989 chr19:19387371 SF4 0.55 6.27 0.33 1.15e-9 Bipolar disorder; CRC cis rs7659604 0.560 rs769238 chr4:122744942 G/A cg19748678 chr4:122722346 EXOSC9 0.65 10.43 0.5 3.44e-22 Type 2 diabetes; CRC cis rs9287719 0.556 rs10168351 chr2:10736810 T/C cg00105475 chr2:10696890 NA 0.46 7.18 0.37 4.56e-12 Prostate cancer; CRC cis rs11122272 0.735 rs2739516 chr1:231505527 G/A cg06096015 chr1:231504339 EGLN1 0.4 5.95 0.31 6.7e-9 Hemoglobin concentration; CRC cis rs13082711 0.863 rs35797268 chr3:27418862 T/C cg02860705 chr3:27208620 NA 0.62 8.79 0.44 8.28e-17 Systolic blood pressure;Diastolic blood pressure;Blood pressure; CRC cis rs7173389 1.000 rs7172796 chr15:73661687 T/G cg01796676 chr15:73680284 NA 0.5 6.89 0.36 2.84e-11 Resting heart rate; CRC cis rs1691799 0.867 rs1168348 chr12:66757168 G/A cg16791601 chr12:66731901 HELB -0.73 -12.82 -0.58 8.7e-31 White blood cell count (basophil); CRC cis rs9768139 0.733 rs12698209 chr7:158117595 A/G cg06219351 chr7:158114137 PTPRN2 0.48 7.41 0.38 1.06e-12 Calcium levels; CRC cis rs6860806 0.661 rs2136187 chr5:131577894 T/C cg18301423 chr5:131593218 PDLIM4 0.38 7.1 0.36 7.96e-12 Breast cancer; CRC cis rs9322193 0.962 rs9322223 chr6:150122645 G/A cg07701084 chr6:150067640 NUP43 0.46 6.54 0.34 2.33e-10 Lung cancer; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg07991241 chr10:33269695 NA 0.48 6.23 0.32 1.42e-9 Thyroid stimulating hormone; CRC cis rs12291225 0.535 rs16930126 chr11:14404983 C/T cg19336497 chr11:14380999 RRAS2 0.46 7.98 0.4 2.43e-14 Sense of smell; CRC cis rs736408 0.608 rs35004449 chr3:52852897 G/T cg11645453 chr3:52864694 ITIH4 0.56 9.75 0.47 6.63e-20 Bipolar disorder; CRC cis rs9398803 0.865 rs9385400 chr6:126764190 G/T cg19875578 chr6:126661172 C6orf173 -0.42 -5.78 -0.3 1.74e-8 Male-pattern baldness; CRC cis rs4731207 0.596 rs1011723 chr7:124605261 G/C cg23710748 chr7:124431027 NA -0.38 -6.08 -0.32 3.35e-9 Cutaneous malignant melanoma; CRC cis rs12681287 0.640 rs13282351 chr8:87484669 C/T cg27223183 chr8:87520930 FAM82B -0.53 -7.52 -0.38 5.31e-13 Caudate activity during reward; CRC cis rs7633770 0.786 rs1607737 chr3:46681846 G/C cg11219411 chr3:46661640 NA 0.53 8.47 0.42 8.51e-16 Coronary artery disease; CRC cis rs2832191 0.967 rs2898160 chr21:30487496 A/G cg08807101 chr21:30365312 RNF160 -0.62 -10.02 -0.48 8.3e-21 Dental caries; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg05384413 chr15:101142580 LINS1;ASB7 0.39 5.96 0.31 6.34e-9 Liver disease severity in Alagille syndrome; CRC cis rs9318086 0.712 rs66683041 chr13:24442090 T/A cg25267304 chr13:24462978 PCOTH;MIPEP 1.03 15.72 0.66 6.14e-42 Myopia (pathological); CRC trans rs1656966 1.000 rs1656966 chr3:186466252 C/T cg19460713 chr2:201170819 SPATS2L 0.4 6.12 0.32 2.59e-9 Myopia (pathological); CRC cis rs938554 0.612 rs4385059 chr4:9989233 A/G cg00071950 chr4:10020882 SLC2A9 -0.44 -5.82 -0.31 1.41e-8 Blood metabolite levels; CRC trans rs10411161 0.702 rs17778790 chr19:52399559 C/T cg22319618 chr22:45562946 NUP50 -0.58 -6.01 -0.31 4.92e-9 Breast cancer; CRC cis rs9487051 0.676 rs6903107 chr6:109597711 A/G cg01475377 chr6:109611718 NA -0.37 -6.58 -0.34 1.85e-10 Reticulocyte fraction of red cells; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg22249281 chr19:41082756 SHKBP1 0.45 6.35 0.33 7.23e-10 Response to antipsychotic treatment; CRC cis rs2243480 1.000 rs73142166 chr7:65375832 A/G cg18252515 chr7:66147081 NA -1.13 -12.89 -0.58 4.63e-31 Diabetic kidney disease; CRC cis rs7824557 0.564 rs2736294 chr8:11234626 T/C cg08071915 chr8:12219732 FAM66A 0.32 5.81 0.31 1.46e-8 Retinal vascular caliber; CRC cis rs6912958 0.935 rs2179844 chr6:88165773 C/A cg08069147 chr6:88032118 GJB7;C6orf162 -0.62 -9.36 -0.46 1.25e-18 Monocyte percentage of white cells; CRC cis rs6570726 0.791 rs2096201 chr6:145934273 C/T cg23711669 chr6:146136114 FBXO30 0.75 12.9 0.58 4.49e-31 Lobe attachment (rater-scored or self-reported); CRC trans rs116095464 0.558 rs62347678 chr5:227496 A/G cg00938859 chr5:1591904 SDHAP3 0.68 7.7 0.39 1.58e-13 Breast cancer; CRC cis rs7845219 0.539 rs713113 chr8:95877787 C/T cg09323728 chr8:95962352 TP53INP1 0.36 5.71 0.3 2.59e-8 Type 2 diabetes; CRC cis rs12142240 0.698 rs17361791 chr1:46812519 A/G cg14993813 chr1:46806288 NSUN4 -0.51 -6.48 -0.34 3.28e-10 Menopause (age at onset); CRC cis rs4290604 0.748 rs78343343 chr2:237965660 A/G cg23555395 chr2:238036564 NA 0.56 5.76 0.3 1.94e-8 Asthma; CRC cis rs11758351 0.866 rs55815656 chr6:26207303 G/A cg22723502 chr6:26240528 HIST1H4F -0.37 -6.16 -0.32 2.18e-9 Gout;Renal underexcretion gout; CRC cis rs3741798 1.000 rs61922054 chr12:12499472 A/G cg08615371 chr12:12503544 MANSC1 1.01 8.92 0.44 3.4e-17 Cerebrospinal fluid biomarker levels; CRC cis rs6952809 1.000 rs6952809 chr7:2448493 T/C cg23289794 chr7:2394357 EIF3B -0.41 -5.68 -0.3 2.96e-8 Multiple sclerosis; CRC cis rs9894429 0.572 rs112417725 chr17:79578219 A/G cg18240062 chr17:79603768 NPLOC4 -0.49 -7.75 -0.39 1.16e-13 Eye color traits; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg08659621 chr20:48552817 RNF114 0.44 6.19 0.32 1.77e-9 Response to antipsychotic treatment; CRC cis rs2882667 0.898 rs6882526 chr5:138382368 A/G cg04439458 chr5:138467593 SIL1 -0.33 -5.99 -0.31 5.53e-9 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs924607 1.000 rs924607 chr5:610093 C/T cg04476341 chr5:669733 TPPP -0.42 -6.95 -0.36 1.99e-11 Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia; CRC cis rs35264875 0.796 rs72928657 chr11:68852336 T/C cg15234197 chr11:68924956 NA 0.44 6.1 0.32 2.9e-9 Blond vs. brown hair color; CRC cis rs2645694 0.626 rs2645708 chr4:77822682 G/A cg10057126 chr4:77819792 ANKRD56 0.33 5.61 0.3 4.41e-8 Emphysema distribution in smoking; CRC cis rs13217239 0.646 rs4583981 chr6:26992023 G/T cg18867708 chr6:26865862 GUSBL1 0.38 5.82 0.31 1.39e-8 Schizophrenia; CRC cis rs10751667 0.621 rs10794351 chr11:946228 C/T cg01483505 chr11:975446 AP2A2 0.44 7.34 0.37 1.74e-12 Alzheimer's disease (late onset); CRC cis rs2692947 0.726 rs13019188 chr2:96774199 A/G cg23100626 chr2:96804247 ASTL -0.28 -7.58 -0.39 3.46e-13 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; CRC cis rs4731207 0.672 rs2286174 chr7:124465876 C/G cg23710748 chr7:124431027 NA 0.38 6.08 0.32 3.42e-9 Cutaneous malignant melanoma; CRC cis rs1862618 0.853 rs2432195 chr5:56120413 C/T cg22800045 chr5:56110881 MAP3K1 0.54 6.02 0.31 4.72e-9 Initial pursuit acceleration; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg26963976 chr16:57023483 NLRC5 0.4 6.18 0.32 1.88e-9 Intelligence (multi-trait analysis); CRC cis rs1580019 0.961 rs766660 chr7:32499077 A/G cg06627557 chr7:32535165 LSM5;AVL9 0.73 11.39 0.53 1.42e-25 Cognitive ability; CRC cis rs1577917 0.876 rs4618490 chr6:86518403 A/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.5 -6.63 -0.34 1.34e-10 Response to antipsychotic treatment; CRC cis rs7586879 0.964 rs6545795 chr2:25116783 C/T cg04586622 chr2:25135609 ADCY3 -0.43 -7.19 -0.37 4.25e-12 Body mass index; CRC cis rs651907 0.557 rs12629954 chr3:101360623 C/A cg11279151 chr3:101281821 RG9MTD1 -0.56 -7.56 -0.38 3.92e-13 Colorectal cancer; CRC cis rs6121246 0.529 rs6058152 chr20:30178107 G/A cg13852791 chr20:30311386 BCL2L1 0.6 8.0 0.4 2.15e-14 Mean corpuscular hemoglobin; CRC cis rs6952808 0.825 rs12669937 chr7:1939765 C/T cg04267008 chr7:1944627 MAD1L1 -0.83 -12.63 -0.57 4.24e-30 Bipolar disorder and schizophrenia; CRC cis rs473651 0.967 rs483042 chr2:239335320 A/G cg21699342 chr2:239360505 ASB1 0.56 10.12 0.49 3.99e-21 Multiple system atrophy; CRC cis rs11105298 0.891 rs10858869 chr12:89857611 C/T cg00757033 chr12:89920650 WDR51B 0.36 6.06 0.32 3.83e-9 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; CRC cis rs6988985 0.530 rs3819497 chr8:143924052 C/T cg10324643 chr8:143916377 GML 0.38 6.54 0.34 2.28e-10 Plasma androstenedione levels in resected early stage-receptor positive breast cancer; CRC trans rs9929218 0.551 rs2296405 chr16:68721470 C/T cg04657470 chr2:198365150 HSPE1;HSPD1 -1.22 -32.16 -0.87 1.41e-103 Colorectal cancer; CRC cis rs4481887 0.861 rs10788778 chr1:248481551 T/C cg13385794 chr1:248469461 NA 0.39 6.74 0.35 6.91e-11 Common traits (Other); CRC cis rs3736485 0.808 rs28576876 chr15:51951252 A/G cg08986416 chr15:51914746 DMXL2 -0.45 -6.46 -0.34 3.79e-10 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC trans rs561341 1.000 rs542132 chr17:30307193 A/T cg27661571 chr11:113659931 NA -0.95 -11.13 -0.52 1.23e-24 Hip circumference adjusted for BMI; CRC cis rs12144309 0.554 rs1970559 chr1:114377148 T/C cg03325407 chr1:114423726 BCL2L15 0.35 6.48 0.34 3.35e-10 Coronary artery disease; CRC cis rs796364 0.806 rs112305133 chr2:201010380 A/G cg23649088 chr2:200775458 C2orf69 -0.58 -5.91 -0.31 8.54e-9 Schizophrenia; CRC cis rs208520 1.000 rs12209225 chr6:66996443 G/T cg07460842 chr6:66804631 NA 0.92 11.19 0.53 7.51e-25 Exhaled nitric oxide output; CRC trans rs7613875 0.578 rs4688753 chr3:50074773 A/G cg21659725 chr3:3221576 CRBN -0.46 -6.84 -0.35 3.92e-11 Body mass index; CRC cis rs1707322 0.717 rs1972410 chr1:46080947 G/T cg03146154 chr1:46216737 IPP 0.67 9.68 0.47 1.17e-19 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg03806916 chr4:25314368 ZCCHC4 0.41 6.38 0.33 6.13e-10 Liver disease severity in Alagille syndrome; CRC cis rs3733585 0.673 rs4447861 chr4:9953940 C/T cg00071950 chr4:10020882 SLC2A9 -0.55 -9.74 -0.47 7.09e-20 Cleft plate (environmental tobacco smoke interaction); CRC cis rs3741151 0.773 rs58564192 chr11:73228904 G/A cg17517138 chr11:73019481 ARHGEF17 0.98 8.0 0.4 2.12e-14 GIP levels in response to oral glucose tolerance test (120 minutes); CRC cis rs7932354 0.583 rs1007738 chr11:46849360 A/G cg19486271 chr11:47235900 DDB2 0.43 6.48 0.34 3.29e-10 Bone mineral density (hip);Bone mineral density; CRC cis rs7726839 0.540 rs72703078 chr5:594987 A/C cg17948913 chr5:572064 NA 0.5 5.79 0.3 1.61e-8 Obesity-related traits; CRC cis rs4563143 0.514 rs73029081 chr19:29295583 C/G cg03161606 chr19:29218774 NA 0.54 6.21 0.32 1.56e-9 Methadone dose in opioid dependence; CRC cis rs11628318 0.614 rs8013886 chr14:103117389 A/G cg12046867 chr14:103022105 NA 0.42 6.1 0.32 2.96e-9 Platelet count; CRC cis rs11212617 0.902 rs61913892 chr11:108340216 T/C cg14761454 chr11:108092087 ATM;NPAT 0.42 6.27 0.33 1.12e-9 Response to metformin in type 2 diabetes (glycemic); CRC cis rs12586317 0.547 rs114371385 chr14:35503724 G/A cg05294307 chr14:35346193 BAZ1A -0.7 -7.6 -0.39 3.22e-13 Psoriasis; CRC cis rs8180040 0.966 rs13059519 chr3:47539969 C/T cg27129171 chr3:47204927 SETD2 0.52 8.06 0.41 1.45e-14 Colorectal cancer; CRC cis rs1784581 0.588 rs7758559 chr6:162438635 G/T cg17173639 chr6:162384350 PARK2 0.62 10.14 0.49 3.32e-21 Itch intensity from mosquito bite; CRC cis rs7914558 0.966 rs11191471 chr10:104702050 T/A cg04362960 chr10:104952993 NT5C2 0.6 9.02 0.45 1.54e-17 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC trans rs1325195 0.840 rs2816177 chr1:179248952 A/G cg08060353 chr15:77889974 NA 0.38 5.98 0.31 5.82e-9 IgE grass sensitization; CRC cis rs3741151 0.773 rs73544783 chr11:73221256 C/G cg17517138 chr11:73019481 ARHGEF17 0.98 8.06 0.41 1.41e-14 GIP levels in response to oral glucose tolerance test (120 minutes); CRC cis rs11190604 1.000 rs10883509 chr10:102296461 C/T cg07080220 chr10:102295463 HIF1AN 0.47 5.64 0.3 3.59e-8 Palmitoleic acid (16:1n-7) levels; CRC cis rs149866169 1 rs149866169 chr6:27441723 T/A cg08798685 chr6:27730294 NA -0.73 -6.55 -0.34 2.16e-10 Neuroticism (multi-trait analysis);Lung cancer in ever smokers;Subjective well-being (multi-trait analysis);Lung cancer;Squamous cell lung carcinoma; CRC cis rs9462027 0.527 rs6939600 chr6:34822176 T/G cg07306190 chr6:34760872 UHRF1BP1 -0.34 -5.9 -0.31 9.06e-9 Systemic lupus erythematosus; CRC cis rs6499255 0.857 rs8060588 chr16:69656500 A/G cg15192750 chr16:69999425 NA 0.55 7.27 0.37 2.58e-12 IgE levels; CRC cis rs853679 0.517 rs3734573 chr6:28059437 T/C cg23161317 chr6:28129485 ZNF389 0.52 6.35 0.33 6.97e-10 Depression; CRC cis rs4819052 0.851 rs2838833 chr21:46665160 C/T cg11663144 chr21:46675770 NA -0.81 -13.98 -0.61 3.46e-35 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs6951245 0.554 rs10270249 chr7:1151886 G/T cg21664854 chr7:1097933 C7orf50;GPR146 0.57 7.28 0.37 2.5e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs7538876 0.903 rs1324368 chr1:17752000 A/G cg01904812 chr1:17746340 RCC2 0.36 5.9 0.31 9.12e-9 Basal cell carcinoma; CRC cis rs921968 0.613 rs2912737 chr2:219545789 A/G cg02176678 chr2:219576539 TTLL4 -0.46 -7.28 -0.37 2.48e-12 Mean corpuscular hemoglobin concentration; CRC cis rs7267979 0.816 rs6037158 chr20:25595466 C/A cg24626310 chr20:25276739 ABHD12;PYGB 0.34 5.9 0.31 8.88e-9 Liver enzyme levels (alkaline phosphatase); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg14824382 chr8:144680115 EEF1D;TIGD5 0.38 6.52 0.34 2.61e-10 Liver disease severity in Alagille syndrome; CRC cis rs6570726 0.791 rs448939 chr6:145808320 T/C cg13319975 chr6:146136371 FBXO30 -0.41 -6.27 -0.33 1.11e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs8177253 1.000 rs6762719 chr3:133480817 A/G cg01448562 chr3:133502909 NA -0.55 -9.38 -0.46 1.1e-18 Iron status biomarkers; CRC cis rs72615157 0.634 rs79986079 chr7:99802044 C/T cg19337854 chr7:99768885 GPC2 0.48 6.42 0.33 4.73e-10 Lung function (FEV1/FVC); CRC cis rs10256972 0.616 rs6957733 chr7:1106327 T/G cg07308232 chr7:1071921 C7orf50 -0.41 -5.85 -0.31 1.17e-8 Longevity;Endometriosis; CRC cis rs2777491 0.574 rs316616 chr15:41746276 G/A cg18705301 chr15:41695430 NDUFAF1 -1.13 -20.62 -0.75 3.1e-61 Ulcerative colitis; CRC cis rs8005677 1.000 rs1951119 chr14:23388326 A/C cg25600027 chr14:23388339 RBM23 -0.53 -8.3 -0.42 2.72e-15 Cognitive ability (multi-trait analysis); CRC cis rs1799949 0.965 rs9897425 chr17:41430179 C/G cg25072359 chr17:41440525 NA 0.52 8.33 0.42 2.25e-15 Menopause (age at onset); CRC cis rs9291683 0.935 rs1860911 chr4:10275057 C/T cg11266682 chr4:10021025 SLC2A9 0.44 9.21 0.45 3.8e-18 Bone mineral density; CRC cis rs2276314 1.000 rs9304153 chr18:33562150 T/C cg19628046 chr18:33552617 C18orf21 0.48 6.33 0.33 7.8e-10 Endometriosis;Drug-induced torsades de pointes; CRC cis rs2179367 0.920 rs638407 chr6:149738350 A/G cg16235748 chr6:149772707 ZC3H12D -0.35 -5.65 -0.3 3.48e-8 Dupuytren's disease; CRC cis rs780096 0.526 rs12476704 chr2:27613031 C/A cg02592271 chr2:27665507 KRTCAP3 -0.27 -5.84 -0.31 1.24e-8 Total body bone mineral density; CRC cis rs7618915 0.547 rs11130314 chr3:52697082 T/C cg07507251 chr3:52567010 NT5DC2 0.42 6.06 0.32 3.7e-9 Bipolar disorder; CRC cis rs939584 1.000 rs6760274 chr2:652272 G/A cg03610516 chr2:642275 NA -0.43 -5.63 -0.3 3.94e-8 Body mass index; CRC cis rs868036 1.000 rs3784719 chr15:68098180 C/T cg05925327 chr15:68127851 NA -0.31 -6.0 -0.31 5.18e-9 Restless legs syndrome; CRC cis rs4713118 0.587 rs9393899 chr6:28133528 G/C cg18032046 chr6:28092343 ZSCAN16 -0.51 -5.93 -0.31 7.47e-9 Parkinson's disease; CRC cis rs13191362 0.872 rs56404230 chr6:163252863 C/T cg06582575 chr6:163149167 PACRG;PARK2 0.68 8.67 0.43 2.05e-16 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs9942416 0.660 rs166183 chr5:74977845 T/C cg19683494 chr5:74908142 NA -0.49 -6.26 -0.33 1.23e-9 Age-related disease endophenotypes; CRC cis rs12135062 0.901 rs2651928 chr1:3101722 C/T cg25382214 chr1:3105252 PRDM16 -0.46 -7.6 -0.39 3.21e-13 Migraine; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg16645202 chr15:92397488 SLCO3A1 0.38 6.4 0.33 5.31e-10 Liver disease severity in Alagille syndrome; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg09013092 chr16:90014962 DEF8 0.41 6.26 0.33 1.22e-9 Intelligence (multi-trait analysis); CRC cis rs1577917 0.710 rs1059306 chr6:86388109 G/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A 0.69 9.22 0.45 3.75e-18 Response to antipsychotic treatment; CRC cis rs780096 0.546 rs715325 chr2:27725572 C/A cg02592271 chr2:27665507 KRTCAP3 -0.25 -5.67 -0.3 3.1e-8 Total body bone mineral density; CRC cis rs9527 0.590 rs1935323 chr10:104877035 T/C cg04362960 chr10:104952993 NT5C2 0.61 8.51 0.42 6.44e-16 Arsenic metabolism; CRC cis rs7552404 1.000 rs6672180 chr1:76123973 C/G cg10523679 chr1:76189770 ACADM 0.83 11.54 0.54 4.12e-26 Blood metabolite levels;Acylcarnitine levels; CRC cis rs7959452 0.590 rs11177628 chr12:69765421 G/A cg20891283 chr12:69753455 YEATS4 0.91 17.38 0.69 1.84e-48 Blood protein levels; CRC cis rs4363385 0.714 rs4845329 chr1:152974454 G/C cg25856811 chr1:152973957 SPRR3 -0.25 -6.76 -0.35 6.27e-11 Inflammatory skin disease; CRC cis rs1707322 0.650 rs4660879 chr1:46105401 C/A cg06784218 chr1:46089804 CCDC17 0.63 11.78 0.54 5.67e-27 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs243505 0.762 rs10241408 chr7:148481488 G/A cg09806900 chr7:148480153 CUL1 0.55 7.94 0.4 3.33e-14 Inflammatory bowel disease;Crohn's disease; CRC cis rs10864907 0.614 rs10199311 chr2:113697961 C/T cg06156847 chr2:113672199 IL1F7 -0.45 -6.76 -0.35 6.47e-11 Pulmonary function; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg25947998 chr8:42948467 SGK196 0.46 6.47 0.34 3.55e-10 Response to antipsychotic treatment; CRC trans rs6956675 1.000 rs1879843 chr7:62586129 A/G cg01314568 chr7:57830625 NA -0.68 -9.37 -0.46 1.21e-18 Obesity-related traits; CRC cis rs6964587 1.000 rs13231578 chr7:91663266 C/T cg17063962 chr7:91808500 NA 0.8 14.42 0.62 7.42e-37 Breast cancer; CRC cis rs208520 0.802 rs1342959 chr6:66883329 A/G cg07460842 chr6:66804631 NA -0.93 -12.55 -0.57 8.48e-30 Exhaled nitric oxide output; CRC cis rs2985684 0.894 rs6572585 chr14:50021075 A/G cg04989706 chr14:50066350 PPIL5 -0.55 -7.7 -0.39 1.5700000000000001e-13 Carotid intima media thickness; CRC cis rs769267 0.965 rs2017964 chr19:19387149 T/C cg01262667 chr19:19385393 TM6SF2 0.36 5.87 0.31 1.06e-8 Tonsillectomy; CRC trans rs12599106 0.754 rs11640596 chr16:34347277 T/C cg15383120 chr6:291909 DUSP22 -0.52 -7.25 -0.37 2.98e-12 Menopause (age at onset); CRC cis rs4713118 0.911 rs9295746 chr6:27730064 T/C cg03623178 chr6:28175578 NA 0.7 8.46 0.42 8.79e-16 Parkinson's disease; CRC cis rs17376456 0.825 rs6865441 chr5:93284746 G/A cg25358565 chr5:93447407 FAM172A 1.11 10.31 0.49 8.49e-22 Diabetic retinopathy; CRC cis rs7613875 0.580 rs12634780 chr3:50043341 A/T cg24110177 chr3:50126178 RBM5 0.56 8.63 0.43 2.69e-16 Body mass index; CRC cis rs1129187 0.755 rs3818554 chr6:42934620 C/T cg05552183 chr6:42928497 GNMT 0.48 7.3 0.37 2.13e-12 Alzheimer's disease in APOE e4+ carriers; CRC cis rs7590720 0.959 rs2372684 chr2:216884764 C/A cg12620499 chr2:216877984 MREG 0.88 14.75 0.63 3.94e-38 Alcohol dependence; CRC trans rs1814175 0.715 rs7479622 chr11:49673340 T/G cg15704280 chr7:45808275 SEPT13 -0.98 -18.42 -0.71 1.46e-52 Height; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg27664600 chr15:44487605 FRMD5 0.45 6.95 0.36 1.91e-11 Intelligence (multi-trait analysis); CRC cis rs11785400 0.793 rs11785376 chr8:143730412 C/T cg10596483 chr8:143751796 JRK 0.48 6.49 0.34 3.23e-10 Schizophrenia; CRC cis rs9443645 0.901 rs10943612 chr6:79698380 C/T cg11833968 chr6:79620685 NA -0.35 -6.04 -0.32 4.19e-9 Intelligence (multi-trait analysis); CRC cis rs2072499 0.778 rs2842868 chr1:156196407 A/C cg24450063 chr1:156163899 SLC25A44 1.04 16.23 0.67 6.22e-44 Testicular germ cell tumor; CRC cis rs2836974 0.613 rs2245455 chr21:40548087 A/T cg06238570 chr21:40685208 BRWD1 -0.74 -11.36 -0.53 1.87e-25 Cognitive function; CRC cis rs9911578 0.741 rs2611776 chr17:56819636 G/T cg12560992 chr17:57184187 TRIM37 0.9 16.38 0.67 1.65e-44 Intelligence (multi-trait analysis); CRC cis rs1448094 0.511 rs10863079 chr12:86152700 T/A cg25456477 chr12:86230367 RASSF9 -0.39 -6.54 -0.34 2.36e-10 Major depressive disorder; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg23132254 chr6:18264719 DEK 0.38 5.96 0.31 6.32e-9 Intelligence (multi-trait analysis); CRC cis rs11785400 0.642 rs4256574 chr8:143725705 C/T cg10596483 chr8:143751796 JRK 0.47 6.37 0.33 6.37e-10 Schizophrenia; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg15171272 chr17:33905444 PEX12 0.41 6.03 0.32 4.36e-9 Intelligence (multi-trait analysis); CRC cis rs9467711 0.651 rs16891261 chr6:26062631 A/G cg19084075 chr6:26124329 HIST1H2AC;HIST1H2BC 0.74 6.43 0.33 4.43e-10 Autism spectrum disorder or schizophrenia; CRC cis rs875971 0.545 rs3936065 chr7:65790564 C/T cg11764359 chr7:65958608 NA 0.45 5.73 0.3 2.21e-8 Aortic root size; CRC cis rs6424115 0.830 rs1130321 chr1:24200524 C/T cg15997130 chr1:24165203 NA 0.73 10.74 0.51 2.79e-23 Immature fraction of reticulocytes; CRC trans rs6833159 0.527 rs10939231 chr4:28829372 A/T cg05063087 chr10:102133314 C10orf75 -0.43 -6.08 -0.32 3.36e-9 Underweight status; CRC cis rs981844 0.740 rs6815202 chr4:154682440 A/G cg10279832 chr4:154682576 RNF175 0.38 5.77 0.3 1.82e-8 Response to statins (LDL cholesterol change); CRC cis rs597539 0.654 rs655816 chr11:68626405 A/G cg06028808 chr11:68637592 NA 0.42 6.81 0.35 4.76e-11 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs523522 0.962 rs7471 chr12:120941215 T/C cg12219531 chr12:120966889 COQ5 0.69 9.28 0.46 2.36e-18 High light scatter reticulocyte count; CRC trans rs9747201 0.963 rs11077982 chr17:80147377 G/C cg07393940 chr7:158741817 NA 0.51 7.38 0.38 1.34e-12 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs28386778 0.799 rs2584612 chr17:61932204 A/G cg11494091 chr17:61959527 GH2 0.59 9.97 0.48 1.2e-20 Prudent dietary pattern; CRC cis rs116095464 0.558 rs10067021 chr5:221490 C/T cg22857025 chr5:266934 NA -1.23 -16.9 -0.68 1.4300000000000001e-46 Breast cancer; CRC cis rs2075371 0.501 rs1613152 chr7:134019837 A/G cg20476274 chr7:133979776 SLC35B4 0.58 8.89 0.44 3.96e-17 Mean platelet volume; CRC cis rs6952808 0.692 rs60755037 chr7:2030104 G/A cg22963979 chr7:1858916 MAD1L1 -0.53 -7.7 -0.39 1.66e-13 Bipolar disorder and schizophrenia; CRC cis rs861020 0.710 rs7516902 chr1:210022179 A/G cg05527609 chr1:210001259 C1orf107 1.06 14.37 0.62 1.14e-36 Orofacial clefts; CRC cis rs4713118 0.911 rs2394000 chr6:27686991 A/G cg06470822 chr6:28175283 NA 0.68 9.05 0.45 1.29e-17 Parkinson's disease; CRC trans rs4576506 0.536 rs10429469 chr9:31497248 G/T cg26940518 chr16:1593766 IFT140;TMEM204 -0.66 -6.11 -0.32 2.86e-9 Psychosis and Alzheimer's disease; CRC cis rs79387448 0.808 rs77518775 chr2:103237642 T/C cg09003973 chr2:102972529 NA 0.63 6.38 0.33 6.02e-10 Gut microbiota (bacterial taxa); CRC cis rs939584 1.000 rs7585056 chr2:631528 A/G cg03610516 chr2:642275 NA 0.43 5.61 0.3 4.36e-8 Body mass index; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg00911488 chr4:106068604 TET2 0.43 6.72 0.35 7.82e-11 Liver disease severity in Alagille syndrome; CRC cis rs7843479 0.509 rs899428 chr8:21770763 T/C cg17168535 chr8:21777572 XPO7 0.6 10.02 0.48 8.79e-21 Mean corpuscular volume; CRC cis rs35264875 0.898 rs72928701 chr11:68861564 C/T cg15234197 chr11:68924956 NA 0.42 5.8 0.3 1.57e-8 Blond vs. brown hair color; CRC cis rs2228479 0.850 rs11640188 chr16:89807732 C/T cg06558623 chr16:89946397 TCF25 1.14 10.79 0.51 1.99e-23 Skin colour saturation; CRC cis rs3617 0.503 rs9866243 chr3:52915219 C/T cg11645453 chr3:52864694 ITIH4 -0.41 -8.02 -0.4 1.93e-14 Red blood cell count;Autism spectrum disorder or schizophrenia; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg07001447 chr2:187350515 ZC3H15 0.43 6.21 0.32 1.56e-9 Intelligence (multi-trait analysis); CRC cis rs875971 0.825 rs1129531 chr7:65619104 C/T cg12463550 chr7:65579703 CRCP -0.52 -7.33 -0.37 1.8e-12 Aortic root size; CRC cis rs1976403 0.659 rs10799700 chr1:21820968 G/C cg20417195 chr1:21767127 NBPF3 0.44 6.59 0.34 1.72e-10 Liver enzyme levels (alkaline phosphatase); CRC cis rs9291683 0.546 rs13146686 chr4:10034933 A/G cg00071950 chr4:10020882 SLC2A9 0.63 11.2 0.53 6.89e-25 Bone mineral density; CRC cis rs12476592 0.602 rs6724160 chr2:63786423 G/C cg10828910 chr2:63850056 LOC388955 0.49 6.11 0.32 2.79e-9 Childhood ear infection; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg02038323 chr12:121477093 OASL 0.45 6.44 0.33 4.25e-10 Response to antipsychotic treatment; CRC cis rs1355223 0.867 rs11821793 chr11:34681462 A/G cg11058730 chr11:34937778 PDHX;APIP -0.43 -5.91 -0.31 8.38e-9 Systemic lupus erythematosus and Systemic sclerosis; CRC cis rs7917772 0.503 rs11191320 chr10:104293394 T/C cg22532475 chr10:104410764 TRIM8 -0.36 -6.62 -0.34 1.43e-10 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC cis rs4974559 0.739 rs6845586 chr4:1323070 G/A cg02980000 chr4:1222292 CTBP1 0.78 8.68 0.43 1.91e-16 Systolic blood pressure; CRC cis rs6582630 0.502 rs4385963 chr12:38295264 G/A cg13010199 chr12:38710504 ALG10B 0.46 6.25 0.33 1.25e-9 Drug-induced liver injury (flucloxacillin); CRC trans rs1814175 0.817 rs28594987 chr11:50045181 C/T cg15704280 chr7:45808275 SEPT13 -0.97 -19.11 -0.73 2.72e-55 Height; CRC cis rs9318086 0.712 rs9510916 chr13:24442789 C/T cg25267304 chr13:24462978 PCOTH;MIPEP 0.62 10.17 0.49 2.64e-21 Myopia (pathological); CRC cis rs9326248 0.559 rs573549 chr11:116736679 A/G cg26566898 chr11:117069891 TAGLN 0.27 5.78 0.3 1.7e-8 Blood protein levels; CRC cis rs28374715 0.662 rs28382348 chr15:41487934 G/C cg18705301 chr15:41695430 NDUFAF1 -0.93 -13.84 -0.61 1.25e-34 Ulcerative colitis; CRC cis rs6502050 0.835 rs4789754 chr17:80091941 C/T cg25804541 chr17:80189381 SLC16A3 -0.29 -5.63 -0.3 3.91e-8 Life satisfaction; CRC cis rs875971 0.638 rs35986979 chr7:66088990 G/A cg25985355 chr7:65971099 NA 0.32 5.69 0.3 2.81e-8 Aortic root size; CRC cis rs13191362 1.000 rs13215491 chr6:163010325 T/C cg06582575 chr6:163149167 PACRG;PARK2 0.75 10.24 0.49 1.58e-21 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs172166 0.561 rs149971 chr6:27982152 G/A cg02683197 chr6:28174875 NA 0.47 6.51 0.34 2.77e-10 Cardiac Troponin-T levels; CRC cis rs2836974 0.544 rs8128919 chr21:40711862 C/T cg11644478 chr21:40555479 PSMG1 0.47 6.79 0.35 5.3e-11 Cognitive function; CRC cis rs55883249 0.957 rs62119432 chr2:9753939 C/T cg23886495 chr2:9695866 ADAM17 0.52 5.97 0.31 6.19e-9 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; CRC cis rs1865760 0.516 rs9295684 chr6:26069669 T/C cg18357526 chr6:26021779 HIST1H4A 0.43 6.05 0.32 4.01e-9 Height; CRC cis rs727563 0.635 rs2899348 chr22:42164516 C/G cg06481639 chr22:41940642 POLR3H 0.56 6.19 0.32 1.75e-9 Crohn's disease;Inflammatory bowel disease; CRC cis rs13082711 0.911 rs4973770 chr3:27425815 C/T cg02860705 chr3:27208620 NA 0.6 8.69 0.43 1.75e-16 Systolic blood pressure;Diastolic blood pressure;Blood pressure; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg06547771 chr11:43380393 TTC17 0.43 5.96 0.31 6.45e-9 Anxiety disorder; CRC trans rs561341 0.883 rs4450460 chr17:30201309 C/T cg27661571 chr11:113659931 NA 0.61 7.18 0.37 4.54e-12 Hip circumference adjusted for BMI; CRC trans rs11039798 0.764 rs10838882 chr11:48393035 T/A cg15704280 chr7:45808275 SEPT13 0.64 6.21 0.32 1.62e-9 Axial length; CRC cis rs651907 0.557 rs3806653 chr3:101396972 T/C cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.62 8.41 0.42 1.3e-15 Colorectal cancer; CRC cis rs3800461 0.544 rs11754548 chr6:34504767 G/C cg17674042 chr6:34482479 PACSIN1 -0.68 -7.93 -0.4 3.45e-14 Chronic lymphocytic leukemia; CRC cis rs10464366 0.614 rs62442213 chr7:39146933 C/T cg21665744 chr7:39171113 POU6F2 0.44 5.86 0.31 1.12e-8 IgG glycosylation; CRC cis rs10504229 1.000 rs17216957 chr8:58179893 C/T cg22535103 chr8:58192502 C8orf71 -0.82 -12.27 -0.56 9.63e-29 Developmental language disorder (linguistic errors); CRC cis rs4731207 0.698 rs2079368 chr7:124485311 C/T cg23710748 chr7:124431027 NA 0.38 6.08 0.32 3.42e-9 Cutaneous malignant melanoma; CRC cis rs1577917 1.000 rs12199516 chr6:86726221 G/A cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.54 -6.95 -0.36 2.02e-11 Response to antipsychotic treatment; CRC cis rs11122272 0.735 rs2749711 chr1:231537543 G/A cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.57 -8.56 -0.43 4.32e-16 Hemoglobin concentration; CRC cis rs947211 0.846 rs823155 chr1:205762946 T/C cg07167872 chr1:205819463 PM20D1 0.48 7.07 0.36 9.12e-12 Parkinson's disease; CRC cis rs4713118 0.629 rs203888 chr6:28021589 C/T cg12273811 chr6:28175739 NA 0.61 8.65 0.43 2.3e-16 Parkinson's disease; CRC cis rs6860806 0.507 rs582490 chr5:131710095 G/A cg11843238 chr5:131593191 PDLIM4 -0.43 -7.33 -0.37 1.86e-12 Breast cancer; CRC cis rs2243480 0.901 rs3813708 chr7:65305632 C/A cg18252515 chr7:66147081 NA -1.2 -13.5 -0.6 2.41e-33 Diabetic kidney disease; CRC cis rs6545977 0.531 rs2539982 chr2:63111004 G/A cg17519650 chr2:63277830 OTX1 0.52 7.82 0.4 7.17e-14 Prostate cancer; CRC cis rs10927875 0.615 rs10927886 chr1:16339313 C/G cg22431228 chr1:16359049 CLCNKA 0.35 6.23 0.32 1.4e-9 Dilated cardiomyopathy; CRC cis rs12200560 0.505 rs11153095 chr6:97078592 T/C cg06623918 chr6:96969491 KIAA0776 -0.51 -7.51 -0.38 5.62e-13 Coronary heart disease; CRC cis rs4930561 0.714 rs1540209 chr11:67928520 A/C cg04465784 chr11:67976953 SUV420H1 -0.3 -6.11 -0.32 2.82e-9 Breast cancer in childhood cancer survivors;IgG glycosylation; CRC cis rs3820068 0.603 rs6668726 chr1:15962614 G/A cg27534772 chr1:16042836 PLEKHM2 0.53 10.38 0.5 4.9e-22 Systolic blood pressure; CRC cis rs9527 0.590 rs7894959 chr10:104756182 C/T cg04362960 chr10:104952993 NT5C2 0.61 8.61 0.43 3.13e-16 Arsenic metabolism; CRC cis rs79149102 0.579 rs7342591 chr15:75306863 C/T cg15902774 chr15:75289873 SCAMP5 -0.53 -6.16 -0.32 2.11e-9 Lung cancer; CRC cis rs919433 1.000 rs6761919 chr2:198163328 A/G cg20885578 chr2:198174922 NA -0.36 -6.41 -0.33 4.95e-10 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC cis rs394563 0.601 rs367133 chr6:149797720 T/G cg07828024 chr6:149772892 ZC3H12D -0.4 -6.63 -0.34 1.35e-10 Dupuytren's disease; CRC cis rs10911363 0.592 rs2702203 chr1:183462513 A/T cg09173681 chr1:183549694 NCF2 0.74 10.31 0.49 8.54e-22 Systemic lupus erythematosus; CRC cis rs17270561 0.562 rs74293932 chr6:26014811 C/A cg17691542 chr6:26056736 HIST1H1C 0.99 12.27 0.56 9.01e-29 Iron status biomarkers; CRC cis rs6429082 0.783 rs291365 chr1:235688043 A/G cg26050004 chr1:235667680 B3GALNT2 0.62 9.33 0.46 1.66e-18 Adiposity; CRC trans rs3780486 0.801 rs56687083 chr9:33132134 A/G cg20290983 chr6:43655470 MRPS18A 1.16 27.12 0.83 6.77e-86 IgG glycosylation; CRC cis rs2758596 0.850 rs2842879 chr1:156163695 G/T cg24450063 chr1:156163899 SLC25A44 0.78 7.43 0.38 9.65e-13 Paclitaxel disposition in epithelial ovarian cancer; CRC cis rs11249608 0.789 rs7706393 chr5:178437737 G/T cg01312482 chr5:178451176 ZNF879 0.37 6.4 0.33 5.37e-10 Pubertal anthropometrics; CRC cis rs7412746 0.611 rs10788794 chr1:150728676 T/C cg18016565 chr1:150552671 MCL1 0.43 5.92 0.31 8.32e-9 Melanoma; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg25704110 chr12:4967040 NA 0.49 6.3 0.33 9.55e-10 Thyroid stimulating hormone; CRC cis rs6804368 0.649 rs2219610 chr3:30762661 A/G cg06106510 chr3:30762233 NA -0.42 -7.49 -0.38 6.48e-13 Blood metabolite levels; CRC cis rs9733 0.519 rs1336899 chr1:150678910 T/C cg17724175 chr1:150552817 MCL1 0.58 9.33 0.46 1.62e-18 Tonsillectomy; CRC cis rs13108904 0.840 rs13149790 chr4:1262239 A/G cg05665937 chr4:1216051 CTBP1 0.4 5.92 0.31 7.95e-9 Obesity-related traits; CRC trans rs2303319 0.504 rs55821334 chr2:162452014 A/G cg14875682 chr5:52083620 ITGA1;PELO -0.72 -5.97 -0.31 6.06e-9 Cognitive function; CRC cis rs4588572 0.643 rs9293747 chr5:77705567 A/G cg11446398 chr5:77624930 NA 0.46 6.38 0.33 6.06e-10 Triglycerides; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg24015594 chr6:33539338 NA 0.43 6.17 0.32 1.97e-9 Response to antipsychotic treatment; CRC trans rs2243480 1.000 rs1796228 chr7:66033084 G/A cg10756647 chr7:56101905 PSPH 0.77 8.04 0.41 1.6e-14 Diabetic kidney disease; CRC cis rs6860806 0.507 rs200837 chr5:131699958 G/A cg20512303 chr5:131592959 PDLIM4 0.37 6.33 0.33 8.16e-10 Breast cancer; CRC cis rs1707322 1.000 rs946527 chr1:46485970 C/T cg06784218 chr1:46089804 CCDC17 0.52 9.32 0.46 1.67e-18 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs12477438 0.798 rs2045057 chr2:99684929 A/G cg14399236 chr2:99771627 LIPT1;TSGA10 -0.74 -10.37 -0.5 5.51e-22 Chronic sinus infection; CRC cis rs6804368 0.649 rs9858466 chr3:30758845 T/A cg06106510 chr3:30762233 NA 0.42 7.55 0.38 4.2e-13 Blood metabolite levels; CRC cis rs11212617 0.967 rs227086 chr11:108244251 A/T cg14761454 chr11:108092087 ATM;NPAT 0.44 6.58 0.34 1.85e-10 Response to metformin in type 2 diabetes (glycemic); CRC cis rs3008870 1.000 rs2815371 chr1:67504313 A/G cg08660285 chr1:67390436 MIER1;WDR78 1.0 14.43 0.62 6.66e-37 Lymphocyte percentage of white cells; CRC cis rs2576037 0.523 rs1539881 chr18:44477897 C/T cg23996704 chr18:44553084 KATNAL2 -0.35 -7.03 -0.36 1.17e-11 Personality dimensions; CRC cis rs9914988 0.887 rs4795463 chr17:27146389 G/C cg12682573 chr17:27188876 MIR451;MIR144 0.57 7.99 0.4 2.37e-14 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs6912958 0.712 rs4498321 chr6:88339251 G/C cg12350822 chr6:88032061 C6orf162;GJB7 -0.32 -6.01 -0.31 5e-9 Monocyte percentage of white cells; CRC cis rs68170813 0.559 rs17429118 chr7:106964052 C/T cg02696742 chr7:106810147 HBP1 -0.61 -6.72 -0.35 7.92e-11 Coronary artery disease; CRC cis rs7173389 1.000 rs8040533 chr15:73664741 T/G cg01796676 chr15:73680284 NA 0.5 6.61 0.34 1.56e-10 Resting heart rate; CRC cis rs1448094 0.511 rs10863079 chr12:86152700 T/A cg00310523 chr12:86230176 RASSF9 -0.38 -6.09 -0.32 3.19e-9 Major depressive disorder; CRC cis rs853679 0.517 rs9368556 chr6:28131153 T/C cg15786705 chr6:28176104 NA 0.78 9.83 0.48 3.57e-20 Depression; CRC cis rs68170813 0.559 rs12535081 chr7:106979291 C/T cg02696742 chr7:106810147 HBP1 -0.55 -6.19 -0.32 1.78e-9 Coronary artery disease; CRC cis rs1707322 1.000 rs7539800 chr1:46262129 C/G cg03146154 chr1:46216737 IPP -0.6 -8.5 -0.42 6.65e-16 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs2243480 1.000 rs4718270 chr7:65202407 A/G cg18252515 chr7:66147081 NA -1.11 -12.77 -0.58 1.31e-30 Diabetic kidney disease; CRC cis rs2836974 0.584 rs6517535 chr21:40653352 G/C cg06238570 chr21:40685208 BRWD1 -0.81 -12.91 -0.58 4.11e-31 Cognitive function; CRC cis rs13108904 0.901 rs6826029 chr4:1307689 A/G cg21620606 chr4:1342894 KIAA1530 0.4 7.11 0.36 7.25e-12 Obesity-related traits; CRC cis rs7552404 0.691 rs1770890 chr1:76401117 A/G cg22875332 chr1:76189707 ACADM -0.48 -6.17 -0.32 2.04e-9 Blood metabolite levels;Acylcarnitine levels; CRC cis rs57994353 0.897 rs12551527 chr9:139358425 C/G cg13856295 chr9:139396418 NOTCH1 -0.43 -5.69 -0.3 2.82e-8 Eosinophil counts;Cutaneous squamous cell carcinoma; CRC cis rs7552404 0.628 rs5745442 chr1:76342858 T/G cg22875332 chr1:76189707 ACADM 0.65 7.82 0.4 7.04e-14 Blood metabolite levels;Acylcarnitine levels; CRC cis rs875971 0.965 rs697968 chr7:65535033 G/A cg12463550 chr7:65579703 CRCP -0.49 -6.98 -0.36 1.6e-11 Aortic root size; CRC cis rs4954585 0.659 rs13018756 chr2:137008235 C/T cg05194412 chr2:137003533 NA 0.43 6.61 0.34 1.55e-10 Colorectal cancer; CRC cis rs4588572 0.643 rs13155648 chr5:77755343 A/G cg11446398 chr5:77624930 NA 0.46 6.24 0.33 1.37e-9 Triglycerides; CRC cis rs883565 0.569 rs1274968 chr3:39170090 A/G cg01426195 chr3:39028469 NA -0.41 -6.95 -0.36 1.96e-11 Handedness; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg05522046 chr3:52931664 TMEM110 0.5 7.0 0.36 1.43e-11 Response to antipsychotic treatment; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg19377384 chr3:140951430 ACPL2 0.49 6.54 0.34 2.33e-10 Thyroid stimulating hormone; CRC cis rs4523957 0.928 rs12453323 chr17:2160214 T/C cg16513277 chr17:2031491 SMG6 0.53 8.76 0.43 1.07e-16 Autism spectrum disorder or schizophrenia;Schizophrenia; CRC cis rs6585424 1.000 rs35025775 chr10:81924285 C/A cg11900509 chr10:81946545 ANXA11 -0.76 -9.32 -0.46 1.78e-18 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs7666738 0.800 rs11941885 chr4:99072921 A/C cg17366294 chr4:99064904 C4orf37 0.42 7.01 0.36 1.34e-11 Colonoscopy-negative controls vs population controls; CRC cis rs9287719 0.649 rs10929684 chr2:10732224 C/T cg00105475 chr2:10696890 NA -0.45 -6.97 -0.36 1.69e-11 Prostate cancer; CRC cis rs9916302 0.904 rs2338797 chr17:37548241 G/A cg03013999 chr17:37608204 MED1 -0.47 -7.44 -0.38 8.58e-13 Glomerular filtration rate (creatinine); CRC cis rs270601 0.913 rs273899 chr5:131695178 G/A cg02033258 chr5:131593261 PDLIM4 0.37 6.27 0.33 1.14e-9 Acylcarnitine levels; CRC cis rs9322193 0.847 rs12234128 chr6:149948689 T/C cg07701084 chr6:150067640 NUP43 0.55 8.04 0.41 1.61e-14 Lung cancer; CRC cis rs11864453 0.826 rs9941087 chr16:72118324 G/A cg23815491 chr16:72088622 HP 0.64 10.21 0.49 1.94e-21 Fibrinogen levels; CRC cis rs8017423 0.647 rs4904679 chr14:90821801 C/T cg14092571 chr14:90743983 NA 0.39 6.04 0.32 4.23e-9 Mortality in heart failure; CRC cis rs62064224 0.614 rs9900089 chr17:30772577 C/T cg18200150 chr17:30822561 MYO1D 0.47 9.09 0.45 9.82e-18 Schizophrenia; CRC cis rs2404602 0.647 rs12904417 chr15:76964152 A/G cg03037974 chr15:76606532 NA 0.53 7.95 0.4 3.06e-14 Blood metabolite levels; CRC cis rs1451375 1.000 rs921451 chr7:50623285 A/G cg18232548 chr7:50535776 DDC 0.45 6.48 0.34 3.32e-10 Malaria; CRC cis rs10752881 0.743 rs10737244 chr1:183098417 G/A ch.1.3577855R chr1:183094577 LAMC1 0.89 15.86 0.66 1.84e-42 Colorectal cancer; CRC cis rs12762955 0.507 rs7070724 chr10:1040138 C/T cg20503657 chr10:835505 NA -0.48 -6.56 -0.34 2.08e-10 Response to angiotensin II receptor blocker therapy; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg24867478 chr11:67029151 NA 0.37 6.24 0.33 1.32e-9 Liver disease severity in Alagille syndrome; CRC cis rs7937840 0.581 rs4963461 chr11:61884044 G/A cg01969543 chr11:61895209 INCENP -0.49 -7.04 -0.36 1.1e-11 Breast cancer; CRC cis rs344364 0.511 rs2917519 chr16:1950479 C/A cg14074117 chr16:1909714 C16orf73 0.41 5.63 0.3 3.77e-8 Glomerular filtration rate in chronic kidney disease; CRC cis rs11792861 0.816 rs11791845 chr9:111683898 G/A cg05043794 chr9:111880884 C9orf5 -0.33 -5.78 -0.3 1.72e-8 Menarche (age at onset); CRC cis rs72634258 0.796 rs4369247 chr1:8168993 C/T cg00042356 chr1:8021962 PARK7 -0.53 -6.23 -0.32 1.46e-9 Inflammatory bowel disease; CRC cis rs9372498 0.536 rs9489460 chr6:118925754 C/T cg01339444 chr6:118972232 C6orf204 0.52 5.74 0.3 2.11e-8 Diastolic blood pressure; CRC cis rs6810498 0.932 rs10155365 chr4:26056021 G/A cg12925881 chr4:26050407 NA -0.42 -7.8 -0.39 8.38e-14 Alcohol dependence; CRC cis rs7178572 0.568 rs11630689 chr15:77520094 C/T cg22256960 chr15:77711686 NA -0.66 -9.57 -0.47 2.66e-19 Type 2 diabetes; CRC cis rs6831352 0.918 rs35662508 chr4:100050974 C/G cg12011299 chr4:100065546 ADH4 -0.49 -9.27 -0.45 2.61e-18 Alcohol dependence; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg06201907 chr1:113249974 RHOC 0.4 6.53 0.34 2.55e-10 Liver disease severity in Alagille syndrome; CRC cis rs1707322 0.929 rs785500 chr1:46593044 C/T cg06784218 chr1:46089804 CCDC17 -0.55 -9.65 -0.47 1.41e-19 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs11628318 0.614 rs7155804 chr14:103114945 A/G cg08075719 chr14:103021372 NA 0.65 7.44 0.38 9e-13 Platelet count; CRC cis rs7762018 0.607 rs80267898 chr6:170040306 G/A cg19338460 chr6:170058176 WDR27 -1.24 -10.21 -0.49 1.89e-21 Thiazide-induced adverse metabolic effects in hypertensive patients; CRC cis rs62229266 0.659 rs2835245 chr21:37416708 C/T cg08632701 chr21:37451849 NA -0.42 -6.54 -0.34 2.32e-10 Mitral valve prolapse; CRC cis rs1005277 0.579 rs1740745 chr10:38520056 T/C cg25427524 chr10:38739819 LOC399744 -0.79 -14.49 -0.62 3.78e-37 Extrinsic epigenetic age acceleration; CRC cis rs17384381 0.834 rs11161614 chr1:85898160 A/C cg16011679 chr1:85725395 C1orf52 0.58 6.34 0.33 7.43e-10 Lobe attachment (rater-scored or self-reported); CRC cis rs12541635 0.934 rs57715289 chr8:106967124 A/T cg10147462 chr8:107024639 NA 0.44 7.05 0.36 1.04e-11 Age of smoking initiation; CRC cis rs67340775 0.541 rs200973 chr6:27858421 A/G cg12273811 chr6:28175739 NA 0.55 5.82 0.31 1.42e-8 Lung cancer in ever smokers; CRC trans rs2228479 0.850 rs11639906 chr16:89798183 T/C cg24644049 chr4:85504048 CDS1 0.9 7.37 0.38 1.39e-12 Skin colour saturation; CRC cis rs1965732 0.958 rs6755529 chr2:3711972 C/T cg00999904 chr2:3704751 ALLC 0.45 6.69 0.35 9.86e-11 Response to inhaled corticosteroid treatment in asthma (change in FEV1); CRC cis rs514406 0.893 rs512723 chr1:53343880 C/T cg25767906 chr1:53392781 SCP2 0.48 7.59 0.39 3.38e-13 Monocyte count; CRC cis rs1448094 0.556 rs2061686 chr12:86170951 C/T cg25456477 chr12:86230367 RASSF9 -0.33 -5.73 -0.3 2.22e-8 Major depressive disorder; CRC cis rs4363385 0.679 rs6686285 chr1:152984561 T/G cg25856811 chr1:152973957 SPRR3 -0.27 -7.25 -0.37 2.99e-12 Inflammatory skin disease; CRC cis rs13256369 0.851 rs13271698 chr8:8567539 C/A cg17143192 chr8:8559678 CLDN23 0.49 6.19 0.32 1.77e-9 Obesity-related traits; CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg13411897 chr3:12526166 TSEN2 0.37 5.98 0.31 5.88e-9 Obesity-related traits; CRC cis rs4972806 0.849 rs2857541 chr2:177029086 C/T cg09355771 chr2:177043147 NA 0.66 9.88 0.48 2.41e-20 IgG glycosylation; CRC cis rs28386778 0.897 rs1062791 chr17:61896487 C/T cg22520471 chr17:61851767 DDX42;CCDC47 0.75 11.65 0.54 1.64e-26 Prudent dietary pattern; CRC cis rs17023223 0.509 rs61806978 chr1:119713215 A/G cg05756136 chr1:119680316 WARS2 -0.52 -7.14 -0.37 6e-12 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for BMI in active individuals; CRC cis rs6496667 0.821 rs8023767 chr15:90883494 C/A cg04176472 chr15:90893244 GABARAPL3 0.56 6.49 0.34 3.13e-10 Rheumatoid arthritis; CRC cis rs11758351 0.660 rs16891443 chr6:26221937 A/C cg01420254 chr6:26195488 NA 0.77 8.59 0.43 3.61e-16 Gout;Renal underexcretion gout; CRC cis rs6961069 0.837 rs1761662 chr7:80238463 C/T cg04458919 chr7:80252533 CD36 -0.34 -6.19 -0.32 1.8e-9 Platelet count; CRC cis rs6582630 0.519 rs11182457 chr12:38538331 G/A cg13010199 chr12:38710504 ALG10B 0.47 5.99 0.31 5.65e-9 Drug-induced liver injury (flucloxacillin); CRC cis rs9467711 0.720 rs3857546 chr6:26157762 C/T cg16898833 chr6:26189333 HIST1H4D 0.64 5.87 0.31 1.04e-8 Autism spectrum disorder or schizophrenia; CRC cis rs9443645 0.808 rs2050661 chr6:79661125 T/C cg09184832 chr6:79620586 NA -0.51 -9.39 -0.46 1.01e-18 Intelligence (multi-trait analysis); CRC cis rs2243480 1.000 rs7787230 chr7:65629099 G/A cg25985355 chr7:65971099 NA 0.53 6.05 0.32 3.9e-9 Diabetic kidney disease; CRC cis rs7647973 1.000 rs8897 chr3:49460407 A/G cg07690219 chr3:49449608 TCTA;RHOA -0.49 -5.8 -0.3 1.53e-8 Menarche (age at onset); CRC cis rs3768617 0.510 rs2296288 chr1:183072590 T/C ch.1.3577855R chr1:183094577 LAMC1 0.87 15.32 0.65 2.39e-40 Fuchs's corneal dystrophy; CRC cis rs2228479 0.850 rs17227057 chr16:89816333 C/T cg06558623 chr16:89946397 TCF25 1.15 10.8 0.51 1.85e-23 Skin colour saturation; CRC cis rs2635047 0.601 rs2635052 chr18:44650607 C/G cg19077165 chr18:44547161 KATNAL2 -0.43 -6.66 -0.34 1.17e-10 Educational attainment; CRC cis rs13631 0.965 rs9411307 chr9:139994947 C/T cg15396367 chr9:139972779 UAP1L1 0.44 6.74 0.35 7.25e-11 Cerebrospinal fluid biomarker levels; CRC cis rs921968 0.541 rs581013 chr2:219432040 G/T cg02176678 chr2:219576539 TTLL4 0.53 8.41 0.42 1.25e-15 Mean corpuscular hemoglobin concentration; CRC cis rs8060686 0.641 rs11075665 chr16:68070774 C/T cg08314208 chr16:67682810 RLTPR -0.56 -6.04 -0.32 4.06e-9 HDL cholesterol;Metabolic syndrome; CRC cis rs6565681 0.943 rs6565683 chr17:78362300 A/T cg15383979 chr17:78362278 RNF213;LOC100294362 -0.57 -6.4 -0.33 5.48e-10 Moyamoya disease; CRC cis rs10752881 1.000 rs10737236 chr1:182988608 C/T ch.1.3577855R chr1:183094577 LAMC1 -0.82 -14.26 -0.62 2.87e-36 Colorectal cancer; CRC cis rs896854 0.967 rs1320164 chr8:95960767 G/A cg23172400 chr8:95962367 TP53INP1 -0.48 -7.96 -0.4 2.89e-14 Type 2 diabetes; CRC cis rs7666738 0.753 rs1527520 chr4:98929164 A/G cg17366294 chr4:99064904 C4orf37 0.43 7.32 0.37 1.95e-12 Colonoscopy-negative controls vs population controls; CRC cis rs2408955 0.542 rs7975632 chr12:48443048 C/T cg15465823 chr12:48382534 COL2A1 0.4 6.71 0.35 8.6e-11 Glycated hemoglobin levels; CRC cis rs9487051 0.768 rs458740 chr6:109525527 C/T cg21918786 chr6:109611834 NA -0.33 -5.7 -0.3 2.65e-8 Reticulocyte fraction of red cells; CRC cis rs6921919 0.697 rs6942030 chr6:28315958 A/T cg15845792 chr6:28175446 NA 0.49 6.58 0.34 1.81e-10 Autism spectrum disorder or schizophrenia; CRC cis rs9291683 0.546 rs13146686 chr4:10034933 A/G cg11266682 chr4:10021025 SLC2A9 0.52 10.46 0.5 2.63e-22 Bone mineral density; CRC cis rs737008 0.960 rs949429 chr16:11376029 C/T cg00044050 chr16:11439710 C16orf75 -0.48 -6.62 -0.34 1.49e-10 Obesity-related traits; CRC cis rs10503871 0.740 rs13249960 chr8:30417532 C/G cg26383811 chr8:30366931 RBPMS 0.41 6.25 0.33 1.25e-9 Metabolite levels (X-11787); CRC cis rs1008375 0.932 rs4698628 chr4:17608620 A/G cg16339924 chr4:17578868 LAP3 0.47 6.24 0.33 1.38e-9 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs9486719 0.947 rs6916232 chr6:96985959 A/T cg06623918 chr6:96969491 KIAA0776 0.77 9.08 0.45 1.05e-17 Migraine;Coronary artery disease; CRC cis rs3820068 0.581 rs72645877 chr1:15928106 G/T cg13390004 chr1:15929781 NA 0.51 7.2 0.37 4.22e-12 Systolic blood pressure; CRC cis rs929354 0.742 rs62491945 chr7:156955580 G/A cg17757837 chr7:157058334 UBE3C 0.74 12.39 0.56 3.31e-29 Body mass index; CRC cis rs6547741 1.000 rs4666009 chr2:27857992 T/A cg27432699 chr2:27873401 GPN1 0.76 13.48 0.6 2.84e-33 Oral cavity cancer; CRC cis rs875971 0.522 rs4718286 chr7:65292764 A/G cg00343986 chr7:65444356 GUSB 0.56 8.49 0.42 6.99e-16 Aortic root size; CRC cis rs7258465 1.000 rs10413237 chr19:18548249 A/C cg06462663 chr19:18546047 ISYNA1 0.48 7.07 0.36 9.46e-12 Breast cancer; CRC cis rs3741404 0.825 rs7111753 chr11:63942189 A/G cg06219103 chr11:63990595 FERMT3 -0.38 -5.62 -0.3 4.18e-8 Platelet count; CRC cis rs10504229 0.861 rs6990796 chr8:58183097 G/C cg24829409 chr8:58192753 C8orf71 -0.68 -11.34 -0.53 2.27e-25 Developmental language disorder (linguistic errors); CRC cis rs79057730 0.599 rs4333501 chr7:803244 C/T cg06242242 chr7:766104 PRKAR1B;HEATR2 0.62 6.71 0.35 8.47e-11 Initial pursuit acceleration; CRC cis rs7635838 0.617 rs367745 chr3:11309274 T/C cg00170343 chr3:11313890 ATG7 0.59 9.05 0.45 1.32e-17 HDL cholesterol; CRC cis rs763121 0.819 rs5750658 chr22:39060917 C/T cg06022373 chr22:39101656 GTPBP1 0.79 12.53 0.57 1.01e-29 Menopause (age at onset); CRC cis rs6860806 0.531 rs272887 chr5:131665713 A/G cg24060327 chr5:131705240 SLC22A5 -0.49 -7.27 -0.37 2.63e-12 Breast cancer; CRC cis rs1552244 0.706 rs279545 chr3:9972493 A/G cg16606324 chr3:10149918 C3orf24 0.46 6.58 0.34 1.8e-10 Alzheimer's disease; CRC cis rs9788721 0.836 rs17483721 chr15:78733731 C/T cg18825076 chr15:78729989 IREB2 0.45 6.84 0.35 3.94e-11 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio;Emphysema imaging phenotypes;Emphysema distribution in smoking;Local histogram emphysema pattern;Post bronchodilator FEV1/FVC ratio in COPD; CRC cis rs911555 0.755 rs2756122 chr14:103983033 C/G cg12935359 chr14:103987150 CKB -0.48 -7.24 -0.37 3.19e-12 Intelligence (multi-trait analysis); CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg08247611 chr16:71928811 KIAA0174 -0.54 -6.4 -0.33 5.26e-10 Diisocyanate-induced asthma; CRC cis rs12541635 0.801 rs12155859 chr8:107105384 C/T cg10147462 chr8:107024639 NA -0.39 -6.05 -0.32 3.92e-9 Age of smoking initiation; CRC cis rs4073416 0.510 rs2268956 chr14:66090145 G/A cg03016385 chr14:66212404 NA -0.45 -6.2 -0.32 1.67e-9 N-glycan levels; CRC cis rs7937682 0.924 rs6589244 chr11:111534333 T/C cg09085632 chr11:111637200 PPP2R1B -1.03 -21.02 -0.76 8.53e-63 Primary sclerosing cholangitis; CRC cis rs7259376 0.936 rs4932760 chr19:22540455 T/G cg02657401 chr19:22469223 NA -0.33 -7.44 -0.38 8.94e-13 Menopause (age at onset); CRC cis rs35110281 0.744 rs162396 chr21:44947807 T/C cg04455712 chr21:45112962 RRP1B 0.41 7.82 0.4 7.32e-14 Mean corpuscular volume; CRC cis rs929596 0.755 rs4148325 chr2:234673309 C/T cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.68 -10.61 -0.51 8e-23 Total bilirubin levels in HIV-1 infection; CRC cis rs2842992 0.789 rs2277072 chr6:160182845 A/G cg19482086 chr6:160211437 TCP1;MRPL18 0.72 9.42 0.46 8.34e-19 Age-related macular degeneration (geographic atrophy); CRC cis rs10788264 0.544 rs9630083 chr10:124017423 C/T cg09507567 chr10:124027408 NA 0.35 7.4 0.38 1.18e-12 Total body bone mineral density; CRC cis rs9910055 0.659 rs7214540 chr17:42256604 A/G cg16434002 chr17:42200994 HDAC5 -0.51 -7.28 -0.37 2.55e-12 Total body bone mineral density; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg12598048 chr15:22892705 CYFIP1 0.41 6.03 0.32 4.4e-9 Intelligence (multi-trait analysis); CRC trans rs916888 0.610 rs199452 chr17:44801340 C/T cg07870213 chr5:140052090 DND1 0.6 8.06 0.41 1.45e-14 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs2204008 0.743 rs11182052 chr12:38450421 T/C cg26384229 chr12:38710491 ALG10B 0.68 9.55 0.47 3.06e-19 Bladder cancer; CRC cis rs1799949 1.000 rs4792981 chr17:41308274 A/G cg23758822 chr17:41437982 NA 0.8 13.63 0.6 7.81e-34 Menopause (age at onset); CRC cis rs10504229 1.000 rs55944282 chr8:58180821 A/G cg22535103 chr8:58192502 C8orf71 -0.82 -12.27 -0.56 9.63e-29 Developmental language disorder (linguistic errors); CRC cis rs4731207 0.623 rs1481342 chr7:124651479 A/C cg23710748 chr7:124431027 NA -0.39 -6.17 -0.32 1.99e-9 Cutaneous malignant melanoma; CRC cis rs6582630 0.519 rs7305570 chr12:38349285 G/A cg26384229 chr12:38710491 ALG10B 0.69 9.79 0.48 4.92e-20 Drug-induced liver injury (flucloxacillin); CRC cis rs9322193 0.886 rs4870055 chr6:150169569 C/T cg00933542 chr6:150070202 PCMT1 0.28 5.85 0.31 1.17e-8 Lung cancer; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg23911465 chr14:75469330 EIF2B2 0.46 6.84 0.35 3.86e-11 Intelligence (multi-trait analysis); CRC cis rs6121246 0.954 rs6121245 chr20:30432060 G/A cg18721089 chr20:30220636 NA -0.35 -5.84 -0.31 1.26e-8 Mean corpuscular hemoglobin; CRC cis rs2795502 1.000 rs3121278 chr10:43375646 G/T cg20628663 chr10:43360327 NA 0.53 8.32 0.42 2.31e-15 Blood protein levels; CRC cis rs853679 0.546 rs200949 chr6:27835435 A/G cg03623178 chr6:28175578 NA 0.8 7.71 0.39 1.5e-13 Depression; CRC cis rs9399135 0.935 rs11760000 chr6:135370496 G/A cg22676075 chr6:135203613 NA 0.39 6.08 0.32 3.36e-9 Red blood cell count; CRC cis rs769267 0.899 rs67720221 chr19:19440864 C/T cg03709012 chr19:19516395 GATAD2A -0.68 -10.34 -0.5 7.1e-22 Tonsillectomy; CRC cis rs6665290 0.835 rs11578479 chr1:227210888 A/T cg10327440 chr1:227177885 CDC42BPA -0.93 -17.97 -0.7 8.73e-51 Myeloid white cell count; CRC cis rs1448094 0.511 rs10863083 chr12:86226739 C/A cg18827107 chr12:86230957 RASSF9 -0.45 -7.42 -0.38 1.02e-12 Major depressive disorder; CRC cis rs12410462 0.681 rs6681096 chr1:227609720 G/A cg23173402 chr1:227635558 NA 0.8 8.37 0.42 1.72e-15 Major depressive disorder; CRC trans rs2303319 0.504 rs2175142 chr2:162450124 T/C cg22988483 chr14:93581567 ITPK1 -0.66 -6.07 -0.32 3.43e-9 Cognitive function; CRC trans rs7267979 0.932 rs1541061 chr20:25521057 G/A cg17903999 chr18:56338584 MALT1 -0.42 -6.87 -0.35 3.17e-11 Liver enzyme levels (alkaline phosphatase); CRC cis rs10876993 0.928 rs1689596 chr12:58053029 T/C cg18357645 chr12:58087776 OS9 0.58 8.02 0.4 1.94e-14 Celiac disease or Rheumatoid arthritis; CRC cis rs17270561 0.609 rs1937132 chr6:25757017 A/G cg16482183 chr6:26056742 HIST1H1C 0.83 10.58 0.5 1e-22 Iron status biomarkers; CRC cis rs10871290 0.881 rs4099290 chr16:74468889 A/G cg01733217 chr16:74700730 RFWD3 -0.72 -11.52 -0.54 5.02e-26 Breast cancer; CRC cis rs1552244 1.000 rs6789156 chr3:10124120 C/T cg10729496 chr3:10149963 C3orf24 0.5 6.56 0.34 2.1e-10 Alzheimer's disease; CRC cis rs55882075 0.967 rs62404346 chr5:179141391 A/C cg14593053 chr5:179126677 CANX 0.48 7.52 0.38 5.32e-13 Monocyte percentage of white cells; CRC cis rs4332037 0.510 rs11764040 chr7:1884830 G/C cg23422044 chr7:1970798 MAD1L1 -0.4 -5.63 -0.3 3.89e-8 Bipolar disorder; CRC cis rs6988985 0.765 rs6433 chr8:143993640 C/T cg10324643 chr8:143916377 GML 0.36 5.87 0.31 1.08e-8 Plasma androstenedione levels in resected early stage-receptor positive breast cancer; CRC cis rs514406 0.800 rs7548519 chr1:53294473 A/G cg27535305 chr1:53392650 SCP2 -0.36 -6.79 -0.35 5.25e-11 Monocyte count; CRC cis rs16852403 0.517 rs12032786 chr1:178236176 A/G cg00404053 chr1:178313656 RASAL2 0.48 6.12 0.32 2.6e-9 Childhood ear infection; CRC cis rs6912958 0.781 rs2284908 chr6:88194500 A/G cg08069147 chr6:88032118 GJB7;C6orf162 -0.57 -8.34 -0.42 2.13e-15 Monocyte percentage of white cells; CRC cis rs12200560 0.505 rs2015196 chr6:97075331 G/C cg06623918 chr6:96969491 KIAA0776 0.52 7.76 0.39 1.08e-13 Coronary heart disease; CRC cis rs2898681 0.614 rs4864680 chr4:53708421 T/G cg00338735 chr4:53728038 RASL11B 0.43 6.41 0.33 5.12e-10 Optic nerve measurement (cup area); CRC cis rs10870270 0.957 rs3829156 chr10:133789386 C/G cg08754478 chr10:133766260 PPP2R2D -0.66 -9.7 -0.47 9.65e-20 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; CRC cis rs1728785 1.000 rs1069288 chr16:68585285 C/G cg02972257 chr16:68554789 NA -0.57 -7.22 -0.37 3.71e-12 Ulcerative colitis; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg09003876 chr18:33552519 C18orf21 0.4 5.99 0.31 5.52e-9 Intelligence (multi-trait analysis); CRC cis rs6540556 0.769 rs12030655 chr1:209922123 G/T cg23920097 chr1:209922102 NA -0.54 -6.69 -0.35 9.58e-11 Red blood cell count; CRC cis rs4713118 0.591 rs2056924 chr6:27690174 G/A cg20933634 chr6:27740509 NA 0.43 6.32 0.33 8.73e-10 Parkinson's disease; CRC cis rs798554 0.679 rs11973498 chr7:2886873 C/A cg04166393 chr7:2884313 GNA12 0.55 7.71 0.39 1.48e-13 Height; CRC cis rs1005277 0.579 rs1621040 chr10:38497232 T/C cg00409905 chr10:38381863 ZNF37A -0.62 -10.27 -0.49 1.16e-21 Extrinsic epigenetic age acceleration; CRC trans rs8073060 0.963 rs11080354 chr17:33872407 A/G cg19694781 chr19:47549865 TMEM160 -0.53 -7.57 -0.39 3.67e-13 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; CRC cis rs7769051 1.000 rs9493445 chr6:133125409 C/T cg07930552 chr6:133119739 C6orf192 0.63 7.69 0.39 1.76e-13 Type 2 diabetes nephropathy; CRC cis rs4663866 1.000 rs34897410 chr2:239182123 T/C cg16914508 chr2:239161102 PER2 0.78 8.01 0.4 2.01e-14 Irritable bowel syndrome; CRC cis rs9733 0.596 rs2065900 chr1:150652202 A/G cg18016565 chr1:150552671 MCL1 0.46 6.74 0.35 6.91e-11 Tonsillectomy; CRC cis rs875971 0.964 rs60193905 chr7:65971260 A/G cg12463550 chr7:65579703 CRCP 0.47 6.78 0.35 5.44e-11 Aortic root size; CRC cis rs758324 0.947 rs559971 chr5:131316164 A/G cg25547332 chr5:131281432 NA 0.39 5.89 0.31 9.4e-9 Alzheimer's disease in APOE e4- carriers; CRC cis rs763121 0.853 rs4820345 chr22:39091151 T/C cg06544989 chr22:39130855 UNC84B 0.45 6.51 0.34 2.73e-10 Menopause (age at onset); CRC cis rs17152411 1.000 rs7086447 chr10:126593553 C/A cg07906193 chr10:126599966 NA 0.58 6.52 0.34 2.69e-10 Height; CRC cis rs7615952 0.599 rs12496921 chr3:125701948 C/G cg06494592 chr3:125709126 NA -0.55 -6.57 -0.34 2e-10 Blood pressure (smoking interaction); CRC cis rs9462027 0.651 rs1543559 chr6:34784104 G/T cg07306190 chr6:34760872 UHRF1BP1 -0.34 -6.09 -0.32 3.16e-9 Systemic lupus erythematosus; CRC trans rs9858542 0.953 rs9814873 chr3:49454112 A/G cg21665057 chr3:196295764 WDR53;FBXO45 -0.62 -8.47 -0.42 8.2e-16 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs9398803 0.865 rs4559102 chr6:126773580 G/A cg19875578 chr6:126661172 C6orf173 0.44 6.12 0.32 2.62e-9 Male-pattern baldness; CRC cis rs6570726 0.764 rs9399553 chr6:145873664 A/T cg23711669 chr6:146136114 FBXO30 0.77 13.45 0.6 3.63e-33 Lobe attachment (rater-scored or self-reported); CRC trans rs2727020 0.576 rs1814175 chr11:49559172 T/C cg11707556 chr5:10655725 ANKRD33B -0.41 -7.61 -0.39 3.01e-13 Coronary artery disease; CRC cis rs911119 0.913 rs6048926 chr20:23580987 C/A cg16589663 chr20:23618590 CST3 0.42 5.81 0.3 1.51e-8 Chronic kidney disease; CRC cis rs2070997 0.756 rs3808820 chr9:133726956 A/T cg01000188 chr9:133769184 QRFP 0.5 5.92 0.31 8.21e-9 Response to amphetamines; CRC cis rs853679 0.546 rs200995 chr6:27813694 C/T cg03623178 chr6:28175578 NA -0.79 -6.91 -0.36 2.6e-11 Depression; CRC cis rs924607 1.000 rs1697978 chr5:642829 A/G cg24163568 chr5:669837 TPPP 0.43 6.77 0.35 5.9e-11 Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia; CRC cis rs7113874 0.589 rs6578969 chr11:8488991 G/A cg20771178 chr11:8615675 STK33 -0.34 -5.68 -0.3 2.92e-8 Body mass index in physically active individuals;Body mass index (joint analysis main effects and physical activity interaction); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg13419809 chr10:102790978 SFXN3;PDZD7 0.4 6.59 0.34 1.79e-10 Liver disease severity in Alagille syndrome; CRC cis rs8060686 0.641 rs59708959 chr16:68123916 A/T cg08314208 chr16:67682810 RLTPR -0.53 -6.0 -0.31 5.24e-9 HDL cholesterol;Metabolic syndrome; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg14321424 chr11:46403087 MDK 0.41 6.49 0.34 3.1e-10 Liver disease severity in Alagille syndrome; CRC trans rs1590305 0.786 rs6563550 chr13:38058413 C/T cg03965764 chr11:45248109 NA -0.59 -6.05 -0.32 3.96e-9 Hip geometry; CRC cis rs644799 0.648 rs1255181 chr11:95472148 T/C cg25622487 chr11:95524042 FAM76B;CEP57 0.44 6.33 0.33 8.22e-10 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs8078723 1.000 rs8078723 chr17:38166879 A/G cg17344932 chr17:38183730 MED24;SNORD124 -0.42 -6.57 -0.34 2.02e-10 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); CRC cis rs11255291 0.668 rs6602265 chr10:7732939 A/G cg00997801 chr10:7671259 ITIH5 0.4 5.95 0.31 6.72e-9 Ovarian reserve; CRC cis rs1059312 0.772 rs11609637 chr12:129300202 T/G cg21616243 chr12:129299702 MGC16384;SLC15A4 -0.75 -13.18 -0.59 3.89e-32 Systemic lupus erythematosus; CRC cis rs780096 0.526 rs704791 chr2:27657167 T/C cg21248554 chr2:27665150 KRTCAP3 -0.34 -7.95 -0.4 3.07e-14 Total body bone mineral density; CRC cis rs17641971 0.684 rs12545097 chr8:49951977 A/G cg00325661 chr8:49890786 NA 0.34 5.78 0.3 1.76e-8 Blood metabolite levels; CRC cis rs10193935 0.901 rs10169411 chr2:42637749 G/A cg27598129 chr2:42591480 NA -0.67 -7.79 -0.39 9.03e-14 Colonoscopy-negative controls vs population controls; CRC cis rs9311474 0.841 rs352139 chr3:52258372 T/C cg18099408 chr3:52552593 STAB1 -0.34 -5.67 -0.3 3.11e-8 Electroencephalogram traits; CRC cis rs1814175 0.529 rs1988417 chr11:49932430 A/G cg27395922 chr11:50257633 LOC441601 -0.41 -7.04 -0.36 1.13e-11 Height; CRC cis rs9403521 0.673 rs3934959 chr6:143979710 A/G cg18240653 chr6:144019428 PHACTR2 -0.51 -6.22 -0.32 1.54e-9 Obesity-related traits; CRC cis rs6570726 0.791 rs7765675 chr6:145915077 A/C cg13319975 chr6:146136371 FBXO30 -0.44 -6.44 -0.33 4.13e-10 Lobe attachment (rater-scored or self-reported); CRC cis rs1707322 0.752 rs61784793 chr1:46149285 G/A cg06784218 chr1:46089804 CCDC17 0.65 12.22 0.56 1.4e-28 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs2882667 0.858 rs11957527 chr5:138404895 T/C cg09476006 chr5:138032270 NA 0.46 7.4 0.38 1.18e-12 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs7945718 0.591 rs4489724 chr11:12684166 G/T cg25843174 chr11:12811716 TEAD1 0.39 7.17 0.37 4.89e-12 Educational attainment (years of education); CRC cis rs2303745 0.544 rs12710308 chr19:17395879 T/A cg02221750 chr19:17393354 ANKLE1 -0.43 -6.56 -0.34 2.03e-10 Systemic lupus erythematosus; CRC trans rs9956878 0.555 rs8085188 chr18:73544676 A/G cg09797645 chr10:35415606 CREM -0.38 -6.14 -0.32 2.33e-9 Obesity-related traits; CRC cis rs7618501 0.602 rs2526754 chr3:50125996 G/A cg24308560 chr3:49941425 MST1R 0.5 8.23 0.41 4.39e-15 Intelligence (multi-trait analysis); CRC cis rs10911232 0.507 rs10752890 chr1:183021910 A/G ch.1.3577855R chr1:183094577 LAMC1 0.82 14.18 0.62 6.1e-36 Hypertriglyceridemia; CRC cis rs12497850 0.966 rs6792510 chr3:48723302 G/C cg07636037 chr3:49044803 WDR6 0.92 15.8 0.66 2.99e-42 Parkinson's disease; CRC cis rs7772486 0.875 rs2814876 chr6:146304030 C/T cg13319975 chr6:146136371 FBXO30 -0.4 -5.97 -0.31 6.08e-9 Lobe attachment (rater-scored or self-reported); CRC trans rs1997103 0.911 rs6949931 chr7:55391081 T/C cg20935933 chr6:143382018 AIG1 0.51 6.48 0.34 3.38e-10 QRS interval (sulfonylurea treatment interaction); CRC trans rs61931739 0.534 rs11053049 chr12:34164537 T/C cg26384229 chr12:38710491 ALG10B 0.55 7.0 0.36 1.44e-11 Morning vs. evening chronotype; CRC cis rs9916302 0.851 rs612209 chr17:37442713 G/C cg15445000 chr17:37608096 MED1 -0.42 -9.15 -0.45 5.94e-18 Glomerular filtration rate (creatinine); CRC cis rs4713118 0.739 rs2893931 chr6:27748010 G/A cg12273811 chr6:28175739 NA 0.5 6.63 0.34 1.38e-10 Parkinson's disease; CRC cis rs56116382 0.604 rs9858428 chr3:49877585 G/T cg01304814 chr3:48885189 PRKAR2A 0.78 6.19 0.32 1.83e-9 Intelligence (multi-trait analysis);High light scatter reticulocyte count; CRC cis rs4964805 0.913 rs36034617 chr12:104203615 G/C cg02344784 chr12:104178138 NT5DC3 0.52 7.48 0.38 6.86e-13 Attention deficit hyperactivity disorder; CRC cis rs17376456 0.825 rs17374166 chr5:93238655 T/C cg25358565 chr5:93447407 FAM172A 1.08 10.5 0.5 1.9e-22 Diabetic retinopathy; CRC cis rs12477438 0.834 rs1563106 chr2:99701381 C/A cg14399236 chr2:99771627 LIPT1;TSGA10 -0.62 -8.73 -0.43 1.26e-16 Chronic sinus infection; CRC cis rs12474201 0.925 rs1058157 chr2:46988275 G/A cg06386533 chr2:46925753 SOCS5 0.8 12.86 0.58 6.01e-31 Height; CRC cis rs7811142 1.000 rs6962151 chr7:100028484 T/C cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.16 17.98 0.7 7.57e-51 Platelet count; CRC cis rs72781680 0.898 rs72786286 chr2:24074659 T/A cg08917208 chr2:24149416 ATAD2B 0.94 9.41 0.46 9.07e-19 Lymphocyte counts; CRC cis rs270601 0.690 rs162907 chr5:131580152 A/G cg04518342 chr5:131593106 PDLIM4 -0.56 -9.75 -0.47 6.97e-20 Acylcarnitine levels; CRC cis rs12477438 0.520 rs11123764 chr2:99750677 T/C cg14399236 chr2:99771627 LIPT1;TSGA10 0.79 13.62 0.6 8.2e-34 Chronic sinus infection; CRC trans rs11098499 0.874 rs12502503 chr4:120116255 C/T cg25214090 chr10:38739885 LOC399744 0.52 7.73 0.39 1.34e-13 Corneal astigmatism; CRC cis rs10504229 1.000 rs17216957 chr8:58179893 C/T cg05313129 chr8:58192883 C8orf71 -0.47 -6.99 -0.36 1.49e-11 Developmental language disorder (linguistic errors); CRC cis rs6500395 0.928 rs4553627 chr16:48708801 A/T cg04672837 chr16:48644449 N4BP1 -0.46 -6.81 -0.35 4.6e-11 Response to tocilizumab in rheumatoid arthritis; CRC trans rs561341 1.000 rs473356 chr17:30321762 G/C cg20587970 chr11:113659929 NA -1.43 -20.38 -0.75 2.82e-60 Hip circumference adjusted for BMI; CRC cis rs60871478 0.945 rs4719279 chr7:813618 T/C cg05535760 chr7:792225 HEATR2 0.78 10.22 0.49 1.78e-21 Cerebrospinal P-tau181p levels; CRC cis rs2228479 1.000 rs117406136 chr16:89974605 C/T cg19635926 chr16:89946313 TCF25 0.61 5.92 0.31 8.24e-9 Skin colour saturation; CRC cis rs977987 0.778 rs8057849 chr16:75443816 T/C cg03315344 chr16:75512273 CHST6 0.54 9.08 0.45 1.01e-17 Dupuytren's disease; CRC cis rs9311474 0.508 rs7652191 chr3:52610415 T/C cg05573699 chr3:52720067 GNL3;PBRM1 -0.47 -6.96 -0.36 1.9e-11 Electroencephalogram traits; CRC cis rs6076065 0.723 rs743022 chr20:23401129 G/C cg11657817 chr20:23433608 CST11 0.44 6.51 0.34 2.8e-10 Facial morphology (factor 15, philtrum width); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg20462845 chr19:3572957 HMG20B 0.4 6.29 0.33 9.86e-10 Liver disease severity in Alagille syndrome; CRC cis rs28386778 0.897 rs894413 chr17:61916347 A/G cg23090583 chr17:61904693 PSMC5;FTSJ3 1.05 20.55 0.75 5.84e-61 Prudent dietary pattern; CRC cis rs3820928 0.904 rs2894623 chr2:227766112 T/C cg11843606 chr2:227700838 RHBDD1 -0.41 -5.94 -0.31 7.15e-9 Pulmonary function; CRC cis rs7178572 1.000 rs7178572 chr15:77747190 A/G cg22256960 chr15:77711686 NA -0.7 -10.93 -0.52 6.29e-24 Type 2 diabetes; CRC cis rs4132509 0.793 rs7538011 chr1:243703344 A/G cg21452805 chr1:244014465 NA 0.54 5.9 0.31 9.14e-9 RR interval (heart rate); CRC cis rs514406 0.798 rs576650 chr1:53327207 C/T cg25767906 chr1:53392781 SCP2 -0.51 -8.26 -0.41 3.59e-15 Monocyte count; CRC cis rs853679 0.517 rs6932109 chr6:28078303 A/G cg21251018 chr6:28226885 NKAPL -0.45 -6.16 -0.32 2.07e-9 Depression; CRC cis rs12745968 0.653 rs12123935 chr1:93175814 C/T cg17283838 chr1:93427260 FAM69A -0.42 -5.75 -0.3 1.99e-8 Bipolar disorder and schizophrenia; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg06937829 chr11:554920 C11orf35 0.45 6.38 0.33 5.98e-10 Response to antipsychotic treatment; CRC cis rs12900413 0.603 rs12905689 chr15:90301343 G/A cg24249390 chr15:90295951 MESP1 -0.62 -9.7 -0.47 9.93e-20 Coronary artery aneurysm in Kawasaki disease; CRC cis rs10876993 0.890 rs1689597 chr12:58051886 G/A cg18357645 chr12:58087776 OS9 0.58 7.89 0.4 4.61e-14 Celiac disease or Rheumatoid arthritis; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg25312481 chr1:10459146 PGD 0.41 7.1 0.36 7.75e-12 Liver disease severity in Alagille syndrome; CRC cis rs6968419 0.781 rs66652906 chr7:115881159 G/A cg02561103 chr7:115862891 TES -0.42 -6.35 -0.33 7.09e-10 Intraocular pressure; CRC cis rs1971762 0.527 rs4759211 chr12:53930945 T/C cg06632207 chr12:54070931 ATP5G2 0.45 7.61 0.39 2.97e-13 Height; CRC cis rs9931543 0.504 rs4784651 chr16:56311774 A/G cg02433656 chr16:56322654 GNAO1 -0.49 -7.47 -0.38 7.51e-13 Subjective well-being; CRC cis rs6942756 0.713 rs691158 chr7:129129982 G/T cg02491457 chr7:128862824 NA -0.58 -7.75 -0.39 1.19e-13 White matter hyperintensity burden; CRC cis rs875971 0.862 rs6460307 chr7:66060871 A/G cg18252515 chr7:66147081 NA -0.42 -6.07 -0.32 3.49e-9 Aortic root size; CRC cis rs875971 0.862 rs6952182 chr7:65683317 T/G cg11764359 chr7:65958608 NA -0.59 -8.7 -0.43 1.59e-16 Aortic root size; CRC cis rs3785574 0.924 rs2584641 chr17:61862889 A/G cg06873352 chr17:61820015 STRADA 0.5 8.09 0.41 1.14e-14 Height; CRC cis rs13108904 0.870 rs1564508 chr4:1244879 A/G cg16405210 chr4:1374714 KIAA1530 -0.45 -6.63 -0.34 1.34e-10 Obesity-related traits; CRC cis rs10493773 1.000 rs10493773 chr1:86125753 C/T cg17807903 chr1:86174739 ZNHIT6 0.49 9.77 0.47 6.01e-20 Urate levels in overweight individuals; CRC cis rs6502050 0.835 rs6502070 chr17:80112634 G/A cg11859384 chr17:80120422 CCDC57 -0.37 -5.87 -0.31 1.08e-8 Life satisfaction; CRC trans rs2018683 1.000 rs4719962 chr7:28999237 G/A cg19402173 chr7:128379420 CALU -0.61 -9.57 -0.47 2.71e-19 Response to irinotecan and platinum-based chemotherapy in non-small-cell lung cancer; CRC cis rs13108904 0.934 rs13125338 chr4:1278435 A/C cg05665937 chr4:1216051 CTBP1 0.4 5.8 0.3 1.54e-8 Obesity-related traits; CRC cis rs6912958 0.535 rs1753154 chr6:88032843 G/C cg08069147 chr6:88032118 GJB7;C6orf162 0.75 12.38 0.56 3.77e-29 Monocyte percentage of white cells; CRC cis rs4713118 0.513 rs9368547 chr6:28028067 A/G cg18032046 chr6:28092343 ZSCAN16 -0.45 -5.99 -0.31 5.44e-9 Parkinson's disease; CRC cis rs820218 0.962 rs820129 chr17:73668107 A/G cg01973089 chr17:73647209 RECQL5 0.33 6.19 0.32 1.84e-9 Rotator cuff tears; CRC cis rs4332037 1.000 rs10240470 chr7:1949971 G/T cg21155852 chr7:2048760 MAD1L1 0.46 6.42 0.33 4.71e-10 Bipolar disorder; CRC cis rs2153904 0.793 rs1772145 chr1:205695695 C/T cg23034840 chr1:205782522 SLC41A1 0.54 7.2 0.37 4.02e-12 Prostate-specific antigen levels; CRC cis rs4819052 0.851 rs2838837 chr21:46665988 C/T cg19498844 chr21:46707878 POFUT2;LOC642852 0.77 11.1 0.52 1.58e-24 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs951366 0.589 rs823099 chr1:205669322 C/A cg24503407 chr1:205819492 PM20D1 0.79 11.45 0.53 8.71e-26 Menarche (age at onset); CRC cis rs6009527 0.752 rs7288176 chr22:49568462 A/G cg12746016 chr22:49560550 NA -0.47 -7.56 -0.38 4.1e-13 Plasma omega-3 polyunsaturated fatty acid levels (alphalinolenic acid); CRC cis rs6577655 0.561 rs6577654 chr8:135593610 G/A cg17885191 chr8:135476712 NA 0.51 5.78 0.3 1.72e-8 Visceral adipose tissue/subcutaneous adipose tissue ratio; CRC cis rs3008870 0.959 rs1886686 chr1:67390468 C/G cg08660285 chr1:67390436 MIER1;WDR78 1.05 15.82 0.66 2.6e-42 Lymphocyte percentage of white cells; CRC cis rs7959452 0.558 rs1478464 chr12:69779789 G/C cg20891283 chr12:69753455 YEATS4 0.86 15.28 0.64 3.36e-40 Blood protein levels; CRC cis rs8180040 0.967 rs17411375 chr3:47395135 C/T cg02527881 chr3:46936655 PTH1R 0.39 7.1 0.36 7.8e-12 Colorectal cancer; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg14298577 chr7:100272703 GNB2 0.4 6.24 0.33 1.33e-9 Liver disease severity in Alagille syndrome; CRC cis rs10489525 0.599 rs34710929 chr1:115606608 G/A cg12756093 chr1:115239321 AMPD1 -0.45 -5.67 -0.3 3.08e-8 Autism; CRC cis rs12681287 0.640 rs13252046 chr8:87477751 G/T cg27223183 chr8:87520930 FAM82B -0.53 -7.52 -0.38 5.31e-13 Caudate activity during reward; CRC cis rs924607 1.000 rs1697978 chr5:642829 A/G cg01605746 chr5:669925 TPPP 0.35 5.74 0.3 2.13e-8 Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia; CRC cis rs2257205 0.667 rs6503874 chr17:56780459 C/G cg25885038 chr17:56607967 SEPT4 -0.52 -5.71 -0.3 2.5e-8 Pancreatic cancer; CRC cis rs600231 0.665 rs2105608 chr11:65228618 T/A cg17120908 chr11:65337727 SSSCA1 -0.55 -8.03 -0.4 1.71e-14 Bone mineral density; CRC cis rs67311347 1.000 rs962847 chr3:40495156 A/G cg24209194 chr3:40518798 ZNF619 -0.43 -6.65 -0.34 1.24e-10 Renal cell carcinoma; CRC cis rs12701220 0.541 rs12535516 chr7:1114440 C/G cg26769984 chr7:1090371 C7orf50 0.54 7.37 0.38 1.37e-12 Bronchopulmonary dysplasia; CRC cis rs2629540 0.765 rs7097254 chr10:126512248 A/C cg08799069 chr10:126477246 METTL10 -0.51 -7.52 -0.38 5.32e-13 Cocaine dependence; CRC cis rs6570726 0.935 rs430561 chr6:145813140 C/T cg05347473 chr6:146136440 FBXO30 0.37 5.86 0.31 1.15e-8 Lobe attachment (rater-scored or self-reported); CRC cis rs9914988 0.887 rs8078402 chr17:27145124 T/A cg12682573 chr17:27188876 MIR451;MIR144 0.57 7.99 0.4 2.37e-14 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs10791323 0.572 rs10894755 chr11:133739685 C/T cg15485101 chr11:133734466 NA -0.48 -8.16 -0.41 7.14e-15 Childhood ear infection; CRC cis rs11785400 0.793 rs4430071 chr8:143737680 T/C cg10596483 chr8:143751796 JRK 0.44 5.9 0.31 8.94e-9 Schizophrenia; CRC cis rs425277 0.583 rs1467217 chr1:2045165 G/A cg12639453 chr1:2035780 PRKCZ -0.39 -7.52 -0.38 5.29e-13 Height; CRC cis rs9858542 0.953 rs67216675 chr3:49493151 G/T cg07274523 chr3:49395745 GPX1 0.48 6.55 0.34 2.2e-10 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs6951245 0.554 rs11761322 chr7:1151657 A/G cg03188948 chr7:1209495 NA 0.54 6.4 0.33 5.38e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs2735413 0.918 rs4888725 chr16:78076761 C/T cg04733911 chr16:78082701 NA -0.45 -7.5 -0.38 6.09e-13 Systolic blood pressure (alcohol consumption interaction); CRC cis rs11997175 0.624 rs4593494 chr8:33692621 C/T cg04338863 chr8:33670619 NA 0.45 6.54 0.34 2.37e-10 Body mass index; CRC cis rs9858542 0.953 rs11715915 chr3:49455330 A/G cg03060546 chr3:49711283 APEH 0.48 6.81 0.35 4.61e-11 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs3018066 0.666 rs78488187 chr4:107037630 C/T cg01869342 chr4:106983673 TBCK 0.46 6.03 0.32 4.52e-9 Cancer; CRC cis rs7959452 0.535 rs11177577 chr12:69671791 C/T cg20891283 chr12:69753455 YEATS4 0.78 13.02 0.58 1.48e-31 Blood protein levels; CRC trans rs3749237 1.000 rs4768 chr3:49758764 A/G cg21659725 chr3:3221576 CRBN 0.57 8.07 0.41 1.3e-14 Resting heart rate; CRC cis rs798554 0.610 rs1182173 chr7:2878016 C/G cg19717773 chr7:2847554 GNA12 -0.44 -7.48 -0.38 6.75e-13 Height; CRC cis rs908922 0.676 rs6587681 chr1:152512135 C/T cg09873164 chr1:152488093 CRCT1 0.38 6.4 0.33 5.37e-10 Hair morphology; CRC cis rs365302 1.000 rs483575 chr6:159651547 C/T cg14500486 chr6:159655392 FNDC1 0.44 6.82 0.35 4.31e-11 Coronary heart disease; CRC cis rs11785693 0.862 rs7007542 chr8:4996718 G/A cg26367366 chr8:4980734 NA 0.79 9.53 0.47 3.55e-19 Neuroticism (multi-trait analysis);Neuroticism; CRC cis rs501120 1.000 rs518594 chr10:44757107 T/C cg09554077 chr10:44749378 NA 0.78 12.0 0.55 9.18e-28 Coronary artery disease;Coronary heart disease; CRC cis rs5769765 0.908 rs9616388 chr22:50313438 T/C cg02269571 chr22:50332266 NA -0.62 -8.02 -0.4 1.83e-14 Schizophrenia; CRC cis rs904251 0.600 rs1874736 chr6:37447994 C/G cg01843034 chr6:37503916 NA -0.37 -6.64 -0.34 1.3100000000000001e-10 Cognitive performance; CRC cis rs1865760 0.566 rs2794720 chr6:26087202 G/C cg17691542 chr6:26056736 HIST1H1C 0.56 8.51 0.42 6.1e-16 Height; CRC cis rs7618915 0.571 rs1961958 chr3:52585990 A/G cg05573699 chr3:52720067 GNL3;PBRM1 -0.44 -6.29 -0.33 1.03e-9 Bipolar disorder; CRC trans rs2303319 0.504 rs12469302 chr2:162433831 G/T cg14875682 chr5:52083620 ITGA1;PELO -0.77 -6.19 -0.32 1.79e-9 Cognitive function; CRC trans rs7618501 0.633 rs9861216 chr3:50059339 A/G cg21659725 chr3:3221576 CRBN -0.55 -8.73 -0.43 1.27e-16 Intelligence (multi-trait analysis); CRC cis rs9302635 0.745 rs35909200 chr16:72156666 T/G cg23815491 chr16:72088622 HP 0.54 5.81 0.3 1.5e-8 Blood protein levels; CRC cis rs6938 0.534 rs12904897 chr15:75217686 A/G cg05627522 chr15:75251581 NA 0.41 6.33 0.33 7.89e-10 Breast cancer; CRC cis rs9640161 0.750 rs59211922 chr7:150023790 T/G cg12556325 chr7:150026731 C7orf29;LRRC61 -0.38 -5.95 -0.31 6.84e-9 Blood protein levels;Circulating chemerin levels; CRC cis rs4076764 0.958 rs11584957 chr1:163392937 C/T cg06092702 chr1:163392909 NA -0.61 -9.59 -0.47 2.27e-19 Motion sickness; CRC cis rs55794721 0.509 rs873308 chr1:25758655 A/G cg27572855 chr1:25598939 RHD -0.37 -6.81 -0.35 4.67e-11 Plateletcrit;Mean corpuscular volume; CRC cis rs9470366 0.545 rs4713999 chr6:36633069 A/G cg08179530 chr6:36648295 CDKN1A -0.54 -7.88 -0.4 4.93e-14 QRS duration; CRC cis rs2011503 0.941 rs56135441 chr19:19371370 A/T cg11584989 chr19:19387371 SF4 0.57 6.76 0.35 6.18e-11 Bipolar disorder; CRC trans rs45509595 0.841 rs2747054 chr6:27783359 A/G cg16898833 chr6:26189333 HIST1H4D 0.72 6.46 0.34 3.84e-10 Breast cancer; CRC cis rs11098499 0.954 rs9998585 chr4:120396802 T/A cg09307838 chr4:120376055 NA 0.71 11.12 0.52 1.39e-24 Corneal astigmatism; CRC cis rs7917772 0.503 rs7915589 chr10:104299264 G/A cg11453585 chr10:104263688 ACTR1A;SUFU 0.91 17.49 0.69 6.57e-49 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC cis rs1707322 0.721 rs4660314 chr1:46229885 T/C cg03146154 chr1:46216737 IPP 0.66 9.56 0.47 2.85e-19 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC trans rs6788895 0.661 rs1533711 chr3:150469996 C/T cg09676794 chr13:100310162 CLYBL 0.63 6.17 0.32 1.95e-9 Breast cancer; CRC cis rs7731657 0.537 rs987024 chr5:130337029 T/G cg08523029 chr5:130500466 HINT1 -0.44 -5.76 -0.3 1.98e-8 Fasting plasma glucose; CRC cis rs4819052 1.000 rs28628220 chr21:46663741 G/C cg19498844 chr21:46707878 POFUT2;LOC642852 0.84 11.26 0.53 4.33e-25 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg18504358 chr14:23340787 LRP10 0.47 6.1 0.32 2.99e-9 Thyroid stimulating hormone; CRC cis rs9674544 0.757 rs4410130 chr17:47122942 C/T cg10950924 chr17:47092072 IGF2BP1 0.37 6.06 0.32 3.69e-9 Primary tooth development (time to first tooth eruption);Primary tooth development (number of teeth); CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg09337511 chr12:112856520 PTPN11 0.46 6.47 0.34 3.48e-10 Anxiety disorder; CRC trans rs7618501 0.633 rs4688689 chr3:50035542 C/T cg21659725 chr3:3221576 CRBN 0.62 9.58 0.47 2.46e-19 Intelligence (multi-trait analysis); CRC cis rs7591163 1.000 rs6744308 chr2:228711816 T/G cg14329157 chr2:228736135 WDR69 -0.47 -6.53 -0.34 2.48e-10 Blood pressure; CRC cis rs4900538 0.855 rs12586378 chr14:102853150 T/C cg18135206 chr14:102964638 TECPR2 -0.98 -17.92 -0.7 1.38e-50 Mean corpuscular volume;Mean corpuscular hemoglobin; CRC cis rs11758351 0.866 rs2069019 chr6:26205604 C/T cg22723502 chr6:26240528 HIST1H4F -0.39 -6.33 -0.33 8.03e-10 Gout;Renal underexcretion gout; CRC cis rs2274273 0.624 rs10129505 chr14:55776375 C/T cg10130446 chr14:55658398 DLGAP5 -0.4 -5.74 -0.3 2.18e-8 Protein biomarker; CRC cis rs6540559 1.000 rs1044516 chr1:209959614 G/T cg22029157 chr1:209979665 IRF6 0.69 9.81 0.48 4.2e-20 Cleft lip with or without cleft palate; CRC trans rs3747547 0.792 rs72726052 chr9:38056290 C/T cg06834177 chr1:6333843 ACOT7 0.77 6.03 0.32 4.44e-9 Metabolite levels (Dihydroxy docosatrienoic acid); CRC cis rs7772486 0.790 rs2249386 chr6:146186611 G/A cg13319975 chr6:146136371 FBXO30 -0.48 -7.27 -0.37 2.6e-12 Lobe attachment (rater-scored or self-reported); CRC cis rs4927850 0.918 rs4361313 chr3:195752260 A/G cg00031303 chr3:195681400 NA 0.51 7.34 0.38 1.67e-12 Pancreatic cancer; CRC cis rs10504229 0.639 rs17331850 chr8:58113538 G/T cg02725872 chr8:58115012 NA -0.65 -11.61 -0.54 2.34e-26 Developmental language disorder (linguistic errors); CRC cis rs3862260 0.509 rs7552885 chr1:120164966 C/T cg11530693 chr1:120165357 ZNF697 0.62 9.75 0.47 6.7e-20 Systemic lupus erythematosus; CRC cis rs7927771 0.524 rs1563821 chr11:47756568 C/T cg20307385 chr11:47447363 PSMC3 0.45 6.36 0.33 6.57e-10 Subjective well-being; CRC trans rs10983614 1.000 rs7867776 chr9:120072627 A/G cg14905632 chr17:38333933 RAPGEFL1 0.42 5.97 0.31 6.29e-9 Survival in pancreatic cancer; CRC trans rs9650657 0.524 rs2163379 chr8:10732050 G/T cg06636001 chr8:8085503 FLJ10661 0.44 5.97 0.31 6.04e-9 Neuroticism; CRC cis rs9487051 0.714 rs6903695 chr6:109631422 C/G cg12927641 chr6:109611667 NA 0.34 6.0 0.31 5.19e-9 Reticulocyte fraction of red cells; CRC cis rs4141404 0.757 rs5749272 chr22:31830351 C/T cg22777020 chr22:31556080 RNF185 -0.45 -6.0 -0.31 5.3e-9 Paclitaxel-induced neuropathy; CRC cis rs9300255 0.679 rs10846507 chr12:123786492 G/T cg00376283 chr12:123451042 ABCB9 0.55 7.17 0.37 4.93e-12 Neutrophil percentage of white cells; CRC trans rs7613875 0.600 rs1138536 chr3:50153356 C/T cg21659725 chr3:3221576 CRBN 0.45 6.49 0.34 3.2e-10 Body mass index; CRC cis rs12950390 0.820 rs58391889 chr17:45865959 A/G cg24803719 chr17:45855879 NA -0.31 -6.82 -0.35 4.38e-11 IgG glycosylation; CRC cis rs2839186 0.900 rs59828751 chr21:47708918 A/G cg02776659 chr21:47717406 C21orf57 -0.34 -5.62 -0.3 4.13e-8 Testicular germ cell tumor; CRC cis rs796364 0.806 rs11694236 chr2:200916230 T/C cg25936922 chr2:200820526 C2orf60;C2orf47 -0.7 -6.57 -0.34 2.02e-10 Schizophrenia; CRC cis rs2882667 0.690 rs288002 chr5:138232087 T/C cg09476006 chr5:138032270 NA 0.54 8.95 0.44 2.66e-17 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs8060686 0.844 rs7196076 chr16:67887494 T/A cg07125278 chr16:67683757 RLTPR -0.62 -6.73 -0.35 7.66e-11 HDL cholesterol;Metabolic syndrome; CRC cis rs2070488 0.965 rs13097628 chr3:38521156 T/C cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.92 16.93 0.68 1.13e-46 Electrocardiographic conduction measures; CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg01839850 chr22:38240395 ANKRD54;MIR658 -0.51 -6.2 -0.32 1.72e-9 Diisocyanate-induced asthma; CRC cis rs911555 0.755 rs34411783 chr14:103900639 G/A cg12935359 chr14:103987150 CKB 0.58 9.5 0.46 4.56e-19 Intelligence (multi-trait analysis); CRC cis rs7224737 1.000 rs7224737 chr17:40289364 A/G cg20291162 chr17:40259547 DHX58 0.49 7.0 0.36 1.45e-11 Fibrinogen levels; CRC cis rs853679 0.517 rs9348796 chr6:28126202 A/G cg12273811 chr6:28175739 NA 0.73 9.16 0.45 5.8e-18 Depression; CRC cis rs10206020 0.921 rs72776302 chr2:1571383 G/A cg26248373 chr2:1572462 NA -0.85 -12.51 -0.57 1.18e-29 IgG glycosylation; CRC trans rs7772172 1.000 rs2073516 chr6:16658617 C/T cg22675453 chr15:52970418 KIAA1370 -0.41 -6.04 -0.32 4.2e-9 Educational attainment (years of education); CRC trans rs2727020 0.566 rs10839234 chr11:49185524 C/T cg15704280 chr7:45808275 SEPT13 -0.85 -14.66 -0.63 8.68e-38 Coronary artery disease; CRC cis rs17065868 0.764 rs61949770 chr13:45024914 T/A cg10246903 chr13:45222710 NA 0.54 5.65 0.3 3.56e-8 Antineutrophil cytoplasmic antibody-associated vasculitis; CRC cis rs9611565 0.512 rs139560 chr22:42194962 A/G cg06634786 chr22:41940651 POLR3H -0.68 -7.65 -0.39 2.27e-13 Vitiligo; CRC cis rs16852403 0.519 rs10913523 chr1:178220000 G/A cg00404053 chr1:178313656 RASAL2 0.52 6.8 0.35 5.02e-11 Childhood ear infection; CRC cis rs7914558 0.933 rs10786729 chr10:104719378 A/G cg15744005 chr10:104629667 AS3MT -0.35 -7.54 -0.38 4.73e-13 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs6964587 0.839 rs62466809 chr7:91472801 A/G cg17063962 chr7:91808500 NA 0.69 11.16 0.52 9.92e-25 Breast cancer; CRC cis rs7666738 0.716 rs35195511 chr4:98859660 G/A cg17366294 chr4:99064904 C4orf37 0.42 6.8 0.35 4.83e-11 Colonoscopy-negative controls vs population controls; CRC cis rs12024301 0.557 rs78012987 chr1:183598625 G/A cg11505048 chr1:183622726 RGL1;APOBEC4 0.76 6.93 0.36 2.16e-11 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs6500395 0.926 rs9936446 chr16:48645807 G/C cg04672837 chr16:48644449 N4BP1 0.42 5.83 0.31 1.31e-8 Response to tocilizumab in rheumatoid arthritis; CRC cis rs1153858 1.000 rs3759899 chr15:45655903 T/C cg21132104 chr15:45694354 SPATA5L1 0.6 8.91 0.44 3.49e-17 Homoarginine levels; CRC cis rs1577917 1.000 rs10944161 chr6:86630376 A/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.52 -6.78 -0.35 5.63e-11 Response to antipsychotic treatment; CRC cis rs7666738 0.830 rs4392515 chr4:98957431 A/G cg17366294 chr4:99064904 C4orf37 0.43 7.34 0.38 1.69e-12 Colonoscopy-negative controls vs population controls; CRC cis rs7044106 0.791 rs4837793 chr9:123483621 G/A cg14255062 chr9:123606675 PSMD5;LOC253039 0.49 7.27 0.37 2.62e-12 Hip circumference adjusted for BMI; CRC cis rs7586879 0.681 rs6723803 chr2:25120713 G/C cg22495460 chr2:25135724 ADCY3 -0.87 -17.11 -0.69 2.25e-47 Body mass index; CRC trans rs2235573 0.527 rs139887 chr22:38371396 G/C cg19894588 chr14:64061835 NA 0.5 7.36 0.38 1.5e-12 Glioblastoma;Glioma; CRC cis rs1552244 0.882 rs17050672 chr3:10025463 G/A cg18598329 chr3:10140678 FANCD2;C3orf24 -0.75 -8.89 -0.44 4.18e-17 Alzheimer's disease; CRC cis rs6500395 1.000 rs8052196 chr16:48691644 C/T cg04672837 chr16:48644449 N4BP1 -0.45 -6.63 -0.34 1.38e-10 Response to tocilizumab in rheumatoid arthritis; CRC cis rs4927850 0.752 rs7624460 chr3:195748530 C/T cg12923728 chr3:195709715 SDHAP1 -0.74 -12.0 -0.55 9.01e-28 Pancreatic cancer; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg20357023 chr2:178417605 TTC30B 0.42 5.98 0.31 5.89e-9 Intelligence (multi-trait analysis); CRC cis rs9847710 0.524 rs11712910 chr3:53094194 C/A cg15147215 chr3:52552868 STAB1 0.43 5.74 0.3 2.1e-8 Ulcerative colitis; CRC cis rs801193 0.569 rs10950050 chr7:66239588 A/C cg00343986 chr7:65444356 GUSB 0.41 5.91 0.31 8.6e-9 Aortic root size; CRC trans rs6928289 0.545 rs12207738 chr6:137674945 C/G cg24169820 chr12:121711996 CAMKK2 -0.42 -6.17 -0.32 2.02e-9 Thiazide-induced adverse metabolic effects in hypertensive patients; CRC cis rs6066835 1.000 rs3817991 chr20:47296365 G/C cg18078177 chr20:47281410 PREX1 0.77 5.69 0.3 2.8e-8 Multiple myeloma; CRC cis rs10504229 0.683 rs2318143 chr8:58114660 C/T cg22535103 chr8:58192502 C8orf71 -0.69 -9.23 -0.45 3.37e-18 Developmental language disorder (linguistic errors); CRC cis rs7666738 0.830 rs7663438 chr4:99014582 C/T cg05340658 chr4:99064831 C4orf37 0.61 9.44 0.46 7.01e-19 Colonoscopy-negative controls vs population controls; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg09329705 chr19:4909474 UHRF1 0.41 6.22 0.32 1.49e-9 Intelligence (multi-trait analysis); CRC cis rs1448094 0.511 rs4278581 chr12:86151054 A/G cg25456477 chr12:86230367 RASSF9 -0.36 -6.07 -0.32 3.43e-9 Major depressive disorder; CRC cis rs875971 0.929 rs12673810 chr7:65923853 T/A cg12463550 chr7:65579703 CRCP 0.48 6.78 0.35 5.54e-11 Aortic root size; CRC cis rs3936840 0.565 rs8011721 chr14:102986388 C/G cg18135206 chr14:102964638 TECPR2 -0.54 -7.12 -0.37 6.83e-12 Plateletcrit; CRC cis rs11098499 0.754 rs10518300 chr4:120249499 G/T cg24375607 chr4:120327624 NA -0.45 -7.21 -0.37 3.91e-12 Corneal astigmatism; CRC cis rs4803468 0.967 rs3826713 chr19:41892269 C/T cg09537434 chr19:41945824 ATP5SL -0.92 -18.26 -0.71 6.02e-52 Height; CRC cis rs3749237 0.964 rs11717463 chr3:49808981 C/T cg03060546 chr3:49711283 APEH 0.54 7.99 0.4 2.38e-14 Resting heart rate; CRC trans rs11098499 0.697 rs10016448 chr4:120298845 A/G cg25214090 chr10:38739885 LOC399744 0.62 9.74 0.47 7.35e-20 Corneal astigmatism; CRC cis rs9584850 0.574 rs61969454 chr13:99170232 T/C cg20487152 chr13:99095054 FARP1 0.42 5.6 0.3 4.44e-8 Neuroticism; CRC cis rs9837602 0.938 rs9814359 chr3:99797013 C/G cg07805332 chr3:99536008 MIR548G;C3orf26 -0.5 -6.67 -0.35 1.09e-10 Breast cancer; CRC cis rs2070488 0.662 rs6599202 chr3:38480651 T/C cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.58 8.85 0.44 5.48e-17 Electrocardiographic conduction measures; CRC trans rs6545883 0.965 rs2305155 chr2:61729258 A/G cg11704114 chr12:21509398 SLCO1A2 -0.32 -6.18 -0.32 1.85e-9 Tuberculosis; CRC trans rs10504229 0.953 rs66676208 chr8:58173866 C/T cg04077850 chr5:125800366 GRAMD3 0.37 6.27 0.33 1.15e-9 Developmental language disorder (linguistic errors); CRC cis rs875971 0.543 rs801191 chr7:66032955 G/A cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.42 -6.26 -0.33 1.22e-9 Aortic root size; CRC cis rs72945132 0.882 rs7121012 chr11:70214421 A/T cg00319359 chr11:70116639 PPFIA1 0.57 6.36 0.33 6.65e-10 Coronary artery disease; CRC cis rs7555523 0.887 rs4657476 chr1:165732661 A/G cg24409356 chr1:165738333 TMCO1 -0.67 -5.92 -0.31 8.17e-9 Intraocular pressure;Glaucoma (high intraocular pressure); CRC cis rs34375054 0.526 rs883315 chr12:125676889 T/C cg06287003 chr12:125626642 AACS -0.51 -7.05 -0.36 1.05e-11 Post bronchodilator FEV1/FVC ratio; CRC cis rs7618915 0.508 rs7628578 chr3:52628321 A/T cg08222913 chr3:52553049 STAB1 -0.35 -6.43 -0.33 4.44e-10 Bipolar disorder; CRC cis rs2415984 0.622 rs10147795 chr14:46936528 C/T cg14871534 chr14:47121158 RPL10L -0.41 -5.96 -0.31 6.59e-9 Number of children ever born; CRC cis rs10504229 0.683 rs11786527 chr8:58131344 G/C cg21724239 chr8:58056113 NA 0.5 6.87 0.35 3.23e-11 Developmental language disorder (linguistic errors); CRC cis rs728616 0.510 rs17617406 chr10:82174556 C/T cg05935833 chr10:81318306 SFTPA2 0.55 6.84 0.35 3.97e-11 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs9494145 0.680 rs4895440 chr6:135426558 A/T cg22676075 chr6:135203613 NA 0.47 6.2 0.32 1.73e-9 Mean platelet volume;Platelet count;Fetal hemoglobin levels in sickle cell anemia;Red blood cell traits; CRC cis rs7659604 0.560 rs769238 chr4:122744942 G/A cg06713675 chr4:122721982 EXOSC9 -0.5 -8.25 -0.41 3.91e-15 Type 2 diabetes; CRC cis rs6952808 0.756 rs12537348 chr7:1948172 C/G cg21782813 chr7:2030301 MAD1L1 0.45 7.63 0.39 2.56e-13 Bipolar disorder and schizophrenia; CRC cis rs2108622 0.727 rs62107763 chr19:15982598 T/C cg13772218 chr19:15982569 NA 0.49 7.01 0.36 1.39e-11 Circulating phylloquinone levels;Vitamin E levels;Acenocoumarol maintenance dosage;Response to Vitamin E supplementation;Metabolite levels;Warfarin maintenance dose; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg16240137 chr5:171615938 STK10 0.42 6.32 0.33 8.37e-10 Response to antipsychotic treatment; CRC cis rs7517126 1.000 rs57050675 chr1:196859544 G/A cg13682187 chr1:196946512 CFHR5 -0.36 -5.63 -0.3 3.9e-8 Blood protein levels; CRC cis rs6598955 0.671 rs6686100 chr1:26617338 G/C cg00852783 chr1:26633632 UBXN11 -0.49 -5.74 -0.3 2.12e-8 Obesity-related traits; CRC cis rs2549003 1.000 rs2706384 chr5:131826880 G/T cg02551604 chr5:131831745 NA 0.57 8.81 0.44 7.42e-17 Asthma (sex interaction); CRC cis rs10504229 0.679 rs72649109 chr8:58031274 A/T cg22535103 chr8:58192502 C8orf71 -0.7 -7.8 -0.4 8.04e-14 Developmental language disorder (linguistic errors); CRC cis rs8180040 0.701 rs11917474 chr3:47010491 G/A cg27129171 chr3:47204927 SETD2 0.65 10.29 0.49 1.04e-21 Colorectal cancer; CRC cis rs875971 0.862 rs6460306 chr7:66060793 T/C cg12463550 chr7:65579703 CRCP -0.47 -6.3 -0.33 9.32e-10 Aortic root size; CRC cis rs10791323 0.604 rs2250025 chr11:133710914 G/A cg06766960 chr11:133703094 NA -0.35 -5.75 -0.3 2.04e-8 Childhood ear infection; CRC cis rs6969780 1.000 rs6973182 chr7:27172321 C/T cg26364809 chr7:27145159 NA -0.69 -6.45 -0.33 4.03e-10 Diastolic blood pressure;Blood pressure traits (multi-trait analysis);Systolic blood pressure;Hypertension; CRC cis rs28386778 0.897 rs4968599 chr17:61835992 T/C cg11494091 chr17:61959527 GH2 0.63 10.73 0.51 3.01e-23 Prudent dietary pattern; CRC cis rs6598955 0.671 rs12141563 chr1:26589636 A/G cg04990556 chr1:26633338 UBXN11 0.56 6.02 0.32 4.53e-9 Obesity-related traits; CRC cis rs6502050 0.805 rs9915071 chr17:80119138 T/C cg09264619 chr17:80180166 NA -0.35 -5.93 -0.31 7.47e-9 Life satisfaction; CRC cis rs1018836 0.851 rs7007129 chr8:91629790 T/G cg16814680 chr8:91681699 NA -0.78 -12.43 -0.57 2.47e-29 Ejection fraction in Tripanosoma cruzi seropositivity; CRC cis rs6502050 0.835 rs8073645 chr17:80110957 C/T cg19223190 chr17:80058835 NA 0.4 6.36 0.33 6.88e-10 Life satisfaction; CRC cis rs453301 0.686 rs2409120 chr8:8882571 G/C cg06636001 chr8:8085503 FLJ10661 -0.51 -7.78 -0.39 9.67e-14 Joint mobility (Beighton score); CRC cis rs4494114 0.967 rs3814342 chr1:39325983 A/G cg25970120 chr1:39325951 RRAGC -0.43 -5.88 -0.31 1.02e-8 Blood protein levels; CRC cis rs9925964 0.748 rs11640961 chr16:30979818 C/T cg02466173 chr16:30829666 NA 0.4 5.63 0.3 3.85e-8 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs4812048 0.649 rs6070706 chr20:57628239 C/T cg14073986 chr20:57617431 SLMO2 0.53 5.64 0.3 3.76e-8 Mean platelet volume; CRC cis rs10504229 0.683 rs7820559 chr8:58142662 C/T cg02290350 chr8:58132656 NA -0.58 -8.14 -0.41 8.29e-15 Developmental language disorder (linguistic errors); CRC cis rs28386778 0.863 rs2727288 chr17:61901197 T/A cg25654072 chr17:61904446 PSMC5;FTSJ3 0.72 11.25 0.53 4.67e-25 Prudent dietary pattern; CRC cis rs875971 0.895 rs7788984 chr7:65915616 A/G cg12463550 chr7:65579703 CRCP 0.49 6.94 0.36 2.06e-11 Aortic root size; CRC cis rs637571 0.615 rs10160792 chr11:65667149 C/G cg26695010 chr11:65641043 EFEMP2 -0.45 -6.6 -0.34 1.64e-10 Eosinophil percentage of white cells; CRC cis rs4728142 0.604 rs10229001 chr7:128599397 C/T cg06630958 chr7:128577819 IRF5 -0.34 -5.64 -0.3 3.74e-8 Inflammatory bowel disease;Systemic lupus erythematosus;Ulcerative colitis; CRC cis rs17155006 0.664 rs410866 chr7:107744543 C/T cg05962710 chr7:107745446 LAMB4 0.39 6.78 0.35 5.47e-11 Pneumococcal bacteremia; CRC cis rs898097 0.756 rs56249965 chr17:80806603 C/G cg16060761 chr17:80687452 NA 0.45 6.53 0.34 2.45e-10 Breast cancer; CRC cis rs947211 0.948 rs863725 chr1:205751196 C/T cg11965913 chr1:205819406 PM20D1 0.45 6.36 0.33 6.79e-10 Parkinson's disease; CRC cis rs7591163 1.000 rs6744308 chr2:228711816 T/G cg20647610 chr2:228736258 WDR69 -0.5 -6.76 -0.35 6.37e-11 Blood pressure; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg27415969 chr3:186500848 EIF4A2 0.46 6.37 0.33 6.3e-10 Response to antipsychotic treatment; CRC trans rs2797369 0.824 rs1775642 chr6:101616270 G/T cg26346621 chr12:6873348 NA -0.38 -6.1 -0.32 2.96e-9 Renal function-related traits (eGRFcrea); CRC cis rs208520 0.690 rs10455594 chr6:66737894 C/G cg07460842 chr6:66804631 NA 1.06 14.78 0.63 2.91e-38 Exhaled nitric oxide output; CRC cis rs12760731 0.668 rs73037529 chr1:178410203 A/T cg00404053 chr1:178313656 RASAL2 0.95 9.79 0.47 5.03e-20 Obesity-related traits; CRC cis rs7103648 0.897 rs2278890 chr11:47399602 G/A cg20307385 chr11:47447363 PSMC3 0.92 14.82 0.63 2.04e-38 Diastolic blood pressure;Systolic blood pressure; CRC cis rs7408868 0.908 rs62113794 chr19:15277337 C/A cg14696996 chr19:15285081 NOTCH3 0.98 9.08 0.45 1.03e-17 Pulse pressure; CRC cis rs7773004 1.000 rs7773004 chr6:26267755 A/G cg13736514 chr6:26305472 NA -0.38 -6.25 -0.33 1.24e-9 Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for body mass index;Waist circumference adjusted for BMI in non-smokers;Waist circumference adjusted for BMI (adjusted for smoking behaviour); CRC trans rs3749237 1.000 rs11130214 chr3:49735746 C/G cg21665057 chr3:196295764 WDR53;FBXO45 -0.55 -7.9 -0.4 4.29e-14 Resting heart rate; CRC cis rs2952156 0.920 rs2517957 chr17:37838716 G/A cg00129232 chr17:37814104 STARD3 -0.72 -12.88 -0.58 5.11e-31 Asthma; CRC cis rs4481887 0.617 rs7511986 chr1:248527810 G/A cg26353448 chr1:248524236 OR2T4 -0.34 -6.97 -0.36 1.72e-11 Common traits (Other); CRC cis rs2415984 0.622 rs17672908 chr14:46934527 T/C cg14871534 chr14:47121158 RPL10L -0.44 -6.19 -0.32 1.76e-9 Number of children ever born; CRC cis rs2625529 0.730 rs2957368 chr15:72329906 C/T cg16672083 chr15:72433130 SENP8 -0.41 -5.98 -0.31 5.84e-9 Red blood cell count; CRC cis rs2204008 0.641 rs2387810 chr12:38368875 G/T cg13010199 chr12:38710504 ALG10B 0.47 6.3 0.33 9.76e-10 Bladder cancer; CRC trans rs4834770 0.746 rs2389747 chr4:120236102 C/T cg25214090 chr10:38739885 LOC399744 0.39 6.13 0.32 2.45e-9 Blood protein levels; CRC cis rs3796619 1.000 rs1466214 chr4:1073760 C/T cg27284194 chr4:1044797 NA 0.39 6.13 0.32 2.57e-9 Recombination rate (males); CRC cis rs853679 0.517 rs17774663 chr6:28120898 G/A cg21251018 chr6:28226885 NKAPL 0.48 6.17 0.32 2.02e-9 Depression; CRC cis rs9733 0.596 rs72702570 chr1:150688196 C/T cg18016565 chr1:150552671 MCL1 0.45 6.52 0.34 2.57e-10 Tonsillectomy; CRC trans rs9329221 0.772 rs7824675 chr8:10243418 G/T cg06636001 chr8:8085503 FLJ10661 -0.57 -9.15 -0.45 6.02e-18 Neuroticism; CRC cis rs4919694 0.611 rs77328741 chr10:105066314 T/C cg04362960 chr10:104952993 NT5C2 0.8 7.63 0.39 2.6e-13 Arsenic metabolism; CRC cis rs34330 0.562 rs17212236 chr12:12855483 G/C cg04607235 chr12:12878440 APOLD1 -0.72 -7.31 -0.37 1.99e-12 Systemic lupus erythematosus; CRC cis rs9911578 0.967 rs12938821 chr17:56959422 T/C cg12560992 chr17:57184187 TRIM37 0.91 16.91 0.68 1.29e-46 Intelligence (multi-trait analysis); CRC cis rs4474465 0.790 rs4945292 chr11:78254424 T/A cg27205649 chr11:78285834 NARS2 0.5 6.32 0.33 8.58e-10 Alzheimer's disease (survival time); CRC trans rs7618501 0.633 rs4688690 chr3:50022292 G/A cg21665057 chr3:196295764 WDR53;FBXO45 0.61 9.54 0.47 3.33e-19 Intelligence (multi-trait analysis); CRC cis rs459571 0.959 rs460888 chr9:136913123 C/G cg13789015 chr9:136890014 NCRNA00094 0.45 5.97 0.31 6.18e-9 Platelet distribution width; CRC cis rs7726839 0.540 rs61580655 chr5:597564 A/G cg16447950 chr5:562315 NA -0.71 -9.55 -0.47 3.07e-19 Obesity-related traits; CRC trans rs7819412 0.775 rs4841490 chr8:10936891 T/C cg06636001 chr8:8085503 FLJ10661 -0.61 -9.23 -0.45 3.41e-18 Triglycerides; CRC cis rs11608355 0.545 rs2302706 chr12:109894028 A/G cg05360138 chr12:110035743 NA 0.77 8.7 0.43 1.65e-16 Neuroticism; CRC trans rs3942852 0.868 rs11039514 chr11:48109598 A/G cg03929089 chr4:120376271 NA -0.5 -6.03 -0.32 4.35e-9 Acute lymphoblastic leukemia (childhood); CRC cis rs11031096 0.542 rs1155146 chr11:3971020 G/A cg18678763 chr11:4115507 RRM1 -0.4 -6.77 -0.35 5.95e-11 Mean corpuscular volume;Mean corpuscular hemoglobin; CRC cis rs2404602 0.684 rs11072600 chr15:76867915 T/C cg03037974 chr15:76606532 NA -0.51 -7.67 -0.39 2.02e-13 Blood metabolite levels; CRC trans rs12599106 0.792 rs76039834 chr16:34598453 G/A cg05064044 chr6:292385 DUSP22 -0.58 -8.09 -0.41 1.17e-14 Menopause (age at onset); CRC cis rs2404602 0.647 rs12439141 chr15:77095423 T/C cg23625390 chr15:77176239 SCAPER -0.85 -12.9 -0.58 4.14e-31 Blood metabolite levels; CRC cis rs4664293 0.867 rs12998291 chr2:160595903 A/G cg08347373 chr2:160653686 CD302 -0.47 -7.43 -0.38 9.32e-13 Monocyte percentage of white cells; CRC cis rs9522267 0.535 rs914036 chr13:112235542 G/A cg26182253 chr13:112236782 NA 0.31 6.33 0.33 7.97e-10 Hepatitis; CRC cis rs2535633 0.588 rs2564930 chr3:53017307 T/C cg15147215 chr3:52552868 STAB1 0.45 7.41 0.38 1.06e-12 Body mass index; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg26512406 chr16:28223152 XPO6 0.43 7.04 0.36 1.14e-11 Liver disease severity in Alagille syndrome; CRC cis rs6011002 0.590 rs1298721 chr20:62352319 T/C cg01176363 chr20:62369445 LIME1 -0.72 -5.67 -0.3 3.18e-8 Dental caries; CRC cis rs801193 0.569 rs6978178 chr7:66123084 G/A cg18252515 chr7:66147081 NA 0.43 6.17 0.32 2.02e-9 Aortic root size; CRC cis rs6752107 1.000 rs12994997 chr2:234173503 G/A cg07618928 chr2:234183455 ATG16L1;SCARNA5 0.66 11.41 0.53 1.27e-25 Crohn's disease;Inflammatory bowel disease; CRC cis rs6598955 0.694 rs6659387 chr1:26634307 G/A cg00852783 chr1:26633632 UBXN11 0.4 6.49 0.34 3.11e-10 Obesity-related traits; CRC cis rs9487051 0.698 rs9374081 chr6:109631782 A/G cg01475377 chr6:109611718 NA -0.38 -5.93 -0.31 7.66e-9 Reticulocyte fraction of red cells; CRC cis rs9322193 0.926 rs952166 chr6:150119910 A/T cg05861140 chr6:150128134 PCMT1 -0.43 -7.05 -0.36 1.03e-11 Lung cancer; CRC cis rs6951245 0.706 rs28685743 chr7:1197736 C/T cg18402987 chr7:1209562 NA 0.74 8.58 0.43 3.68e-16 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs1883415 0.750 rs2076316 chr6:24489741 A/C cg20631270 chr6:24437470 GPLD1 0.39 5.7 0.3 2.74e-8 Liver enzyme levels (alkaline phosphatase); CRC cis rs73206853 0.563 rs9706438 chr12:111195158 A/G cg12870014 chr12:110450643 ANKRD13A 0.73 8.42 0.42 1.19e-15 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC cis rs7617773 0.817 rs3731513 chr3:48219537 A/G cg11946769 chr3:48343235 NME6 0.72 9.78 0.47 5.4e-20 Coronary artery disease; CRC cis rs10865541 0.902 rs33997548 chr2:3419366 A/G cg22182287 chr2:3452347 TTC15 0.38 6.06 0.32 3.71e-9 Obesity-related traits; CRC trans rs17685 0.753 rs2302435 chr7:75676987 G/A cg19862616 chr7:65841803 NCRNA00174 -1.0 -18.5 -0.71 7.07e-53 Coffee consumption;Coffee consumption (cups per day); CRC cis rs25645 0.502 rs7209742 chr17:38108708 A/G cg26162295 chr17:38119207 GSDMA -0.34 -5.67 -0.3 3.09e-8 Myeloid white cell count; CRC cis rs55823223 0.564 rs9894009 chr17:73850414 C/T cg14829360 chr17:73884958 NA -0.44 -7.05 -0.36 1.07e-11 Psoriasis; CRC cis rs1997103 0.954 rs2030807 chr7:55378485 A/G cg17469321 chr7:55412551 NA 0.74 11.32 0.53 2.51e-25 QRS interval (sulfonylurea treatment interaction); CRC cis rs1816752 0.817 rs7985394 chr13:25012852 C/G cg02811702 chr13:24901961 NA 0.47 6.55 0.34 2.21e-10 Obesity-related traits; CRC cis rs6502050 0.769 rs8079122 chr17:80120427 G/T cg22110888 chr17:80059540 CCDC57 0.4 6.31 0.33 9.05e-10 Life satisfaction; CRC cis rs7107174 1.000 rs2511180 chr11:77937255 A/G cg02023728 chr11:77925099 USP35 0.54 8.37 0.42 1.69e-15 Testicular germ cell tumor; CRC cis rs12142240 0.660 rs6679080 chr1:46819779 A/T cg14993813 chr1:46806288 NSUN4 -0.48 -6.15 -0.32 2.24e-9 Menopause (age at onset); CRC cis rs10504229 1.000 rs76944716 chr8:58191643 T/C cg02725872 chr8:58115012 NA -0.37 -5.98 -0.31 5.7e-9 Developmental language disorder (linguistic errors); CRC cis rs7772486 0.875 rs1331639 chr6:146431869 A/G cg23711669 chr6:146136114 FBXO30 -0.63 -10.67 -0.51 4.94e-23 Lobe attachment (rater-scored or self-reported); CRC cis rs1552244 0.882 rs113268531 chr3:10167069 A/G cg08888203 chr3:10149979 C3orf24 0.7 9.58 0.47 2.4e-19 Alzheimer's disease; CRC cis rs10504229 0.815 rs75577263 chr8:58188434 A/G cg24829409 chr8:58192753 C8orf71 -0.68 -11.34 -0.53 2.27e-25 Developmental language disorder (linguistic errors); CRC cis rs7552404 0.924 rs1146574 chr1:76202671 A/G cg03433033 chr1:76189801 ACADM 0.74 11.25 0.53 4.8e-25 Blood metabolite levels;Acylcarnitine levels; CRC trans rs9858542 0.903 rs9875617 chr3:49634696 G/A cg21659725 chr3:3221576 CRBN -0.72 -9.73 -0.47 8e-20 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs2836950 0.509 rs11088466 chr21:40580017 T/A cg17971929 chr21:40555470 PSMG1 -0.58 -8.44 -0.42 1.05e-15 Menarche (age at onset); CRC cis rs4938330 0.608 rs2239011 chr11:117088994 A/G cg01368799 chr11:117014884 PAFAH1B2 -0.47 -6.04 -0.32 4.26e-9 Blood protein levels; CRC cis rs1129187 0.755 rs9462855 chr6:42925936 G/C cg26304593 chr6:42947056 PEX6 -0.47 -6.83 -0.35 4.2e-11 Alzheimer's disease in APOE e4+ carriers; CRC cis rs9527 0.571 rs7904113 chr10:104633114 G/T cg08772003 chr10:104629869 AS3MT -0.35 -5.81 -0.31 1.47e-8 Arsenic metabolism; CRC trans rs875971 0.545 rs1796226 chr7:66087710 C/T cg02869306 chr7:64672164 INTS4L1 -0.44 -6.35 -0.33 6.99e-10 Aortic root size; CRC cis rs4862750 0.957 rs4861733 chr4:187903933 C/T cg07414643 chr4:187882934 NA 0.35 5.84 0.31 1.27e-8 Lobe attachment (rater-scored or self-reported); CRC cis rs17376456 0.825 rs17372057 chr5:93071916 C/A cg09848695 chr5:92956644 FAM172A;MIR2277 0.66 6.07 0.32 3.58e-9 Diabetic retinopathy; CRC cis rs66569888 0.789 rs17213078 chr2:106734065 G/A cg15412446 chr2:106886593 NA -0.5 -6.97 -0.36 1.7e-11 Facial morphology (factor 23); CRC cis rs1059312 0.522 rs3825181 chr12:129279264 G/A cg09035930 chr12:129282057 SLC15A4 -0.43 -6.61 -0.34 1.58e-10 Systemic lupus erythematosus; CRC cis rs911119 1.000 rs6114209 chr20:23622266 G/C cg16589663 chr20:23618590 CST3 0.62 7.97 0.4 2.59e-14 Chronic kidney disease; CRC cis rs10256972 0.591 rs10229680 chr7:1158565 C/T cg26608667 chr7:1196370 ZFAND2A 0.38 5.85 0.31 1.2e-8 Longevity;Endometriosis; CRC cis rs7412746 0.611 rs10888391 chr1:150729983 G/A cg17724175 chr1:150552817 MCL1 0.48 7.04 0.36 1.12e-11 Melanoma; CRC cis rs7149337 0.869 rs10137481 chr14:51694614 C/T cg18683604 chr14:51561293 TRIM9 0.3 5.85 0.31 1.22e-8 Cancer; CRC trans rs629535 0.814 rs652483 chr8:70055083 G/A cg21567404 chr3:27674614 NA 0.96 16.25 0.67 5.03e-44 Dupuytren's disease; CRC cis rs4731207 0.564 rs6977313 chr7:124681732 C/T cg23710748 chr7:124431027 NA -0.39 -6.14 -0.32 2.35e-9 Cutaneous malignant melanoma; CRC cis rs60871478 1.000 rs7795258 chr7:795227 A/G cg13844804 chr7:814759 HEATR2 0.64 8.31 0.42 2.52e-15 Cerebrospinal P-tau181p levels; CRC cis rs9916302 0.904 rs2303316 chr17:37704217 A/G cg03013999 chr17:37608204 MED1 0.45 7.03 0.36 1.2e-11 Glomerular filtration rate (creatinine); CRC cis rs1395 0.710 rs11674947 chr2:27471996 A/G cg14242246 chr2:27434262 C2orf28;SLC5A6 0.31 5.97 0.31 6.06e-9 Blood metabolite levels; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg24002213 chr7:91764177 CYP51A1 0.46 6.47 0.34 3.48e-10 Anxiety disorder; CRC cis rs1580019 0.563 rs13244332 chr7:32537679 G/A cg06627557 chr7:32535165 LSM5;AVL9 1.0 19.95 0.74 1.37e-58 Cognitive ability; CRC cis rs644799 0.710 rs473852 chr11:95568757 C/A cg25622487 chr11:95524042 FAM76B;CEP57 0.8 13.59 0.6 1.12e-33 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs898097 1.000 rs898097 chr17:80904310 C/T cg03160526 chr17:80928410 B3GNTL1 0.46 6.99 0.36 1.56e-11 Breast cancer; CRC cis rs56104184 0.615 rs73061693 chr19:49399941 C/A cg21252483 chr19:49399788 TULP2 -0.43 -6.62 -0.34 1.49e-10 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; CRC cis rs67385638 1.000 rs2855039 chr11:5271671 C/T cg21506790 chr11:5277210 HBG2 0.35 5.87 0.31 1.07e-8 Hemoglobin levels; CRC trans rs8035957 1.000 rs4924273 chr15:38846738 C/G cg22263405 chr18:42259244 SETBP1 -0.45 -6.01 -0.31 4.96e-9 Type 1 diabetes; CRC cis rs10979 1.000 rs1416208 chr6:143889241 T/A cg25407410 chr6:143891975 LOC285740 -0.83 -13.56 -0.6 1.37e-33 Hypospadias; CRC cis rs7224737 1.000 rs8074708 chr17:40286354 A/G cg02228675 chr17:40259724 DHX58 0.48 6.82 0.35 4.27e-11 Fibrinogen levels; CRC cis rs10883723 0.773 rs11191303 chr10:104255158 T/C cg04362960 chr10:104952993 NT5C2 -0.43 -6.1 -0.32 2.92e-9 Allergic disease (asthma, hay fever or eczema); CRC cis rs2242116 0.796 rs4683297 chr3:46973673 T/C cg02527881 chr3:46936655 PTH1R 0.49 8.87 0.44 4.69e-17 Birth weight; CRC cis rs7085104 0.632 rs7096475 chr10:104609676 A/G cg15744005 chr10:104629667 AS3MT -0.34 -7.05 -0.36 1.03e-11 Immature fraction of reticulocytes;Schizophrenia; CRC cis rs7089973 0.525 rs11196945 chr10:116600424 G/A cg23260525 chr10:116636907 FAM160B1 0.35 8.13 0.41 8.85e-15 Bipolar disorder or attention deficit hyperactivity disorder; CRC cis rs9409565 0.826 rs4744345 chr9:97207669 G/A cg04523069 chr9:97136363 HIATL1 0.37 5.67 0.3 3.05e-8 Colorectal cancer (alcohol consumption interaction); CRC cis rs2243480 1.000 rs4718270 chr7:65202407 A/G cg12463550 chr7:65579703 CRCP 0.67 6.28 0.33 1.09e-9 Diabetic kidney disease; CRC cis rs7703744 0.681 rs73239280 chr5:118695579 G/A cg23985447 chr5:118691066 TNFAIP8 0.43 6.17 0.32 1.97e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs6684514 0.506 rs3762281 chr1:156304782 A/G cg20302342 chr1:156215951 PAQR6 0.38 7.44 0.38 8.78e-13 Mean corpuscular hemoglobin concentration;Glycated hemoglobin levels; CRC cis rs3760982 0.813 rs8104447 chr19:44293278 T/C cg11993925 chr19:44307056 LYPD5 -0.48 -7.94 -0.4 3.2e-14 Breast cancer (estrogen-receptor negative);Breast cancer; CRC cis rs7223966 0.921 rs2006123 chr17:61958669 G/T cg23090583 chr17:61904693 PSMC5;FTSJ3 0.46 5.74 0.3 2.17e-8 Hip circumference adjusted for BMI;Body mass index; CRC cis rs12291225 0.585 rs4517475 chr11:14386145 A/G cg05501817 chr11:14380813 RRAS2 -0.47 -6.51 -0.34 2.8e-10 Sense of smell; CRC cis rs6951245 1.000 rs78308415 chr7:1072634 G/A cg24642844 chr7:1081250 C7orf50 -0.79 -9.49 -0.46 4.98e-19 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs17095355 1.000 rs12263484 chr10:111697255 A/G cg00817464 chr10:111662876 XPNPEP1 -0.62 -9.12 -0.45 7.4e-18 Biliary atresia; CRC cis rs7666738 0.830 rs11944107 chr4:98931638 G/C cg05340658 chr4:99064831 C4orf37 0.6 9.35 0.46 1.41e-18 Colonoscopy-negative controls vs population controls; CRC cis rs12887734 0.546 rs4900597 chr14:104266664 A/G cg08213375 chr14:104286397 PPP1R13B -0.51 -8.69 -0.43 1.69e-16 Schizophrenia;Autism spectrum disorder or schizophrenia; CRC cis rs3796352 1.000 rs13072395 chr3:52980573 T/C cg07884673 chr3:53033167 SFMBT1 0.79 6.22 0.32 1.51e-9 Immune reponse to smallpox (secreted IL-2); CRC cis rs1891275 0.515 rs4244930 chr10:93466849 T/C cg07889827 chr10:93443413 NA -0.39 -6.45 -0.33 4.1e-10 Intelligence (multi-trait analysis); CRC trans rs62103177 0.525 rs4799116 chr18:77736735 A/G cg05926928 chr17:57297772 GDPD1 -0.63 -7.01 -0.36 1.4e-11 Opioid sensitivity; CRC cis rs17443541 0.507 rs6711524 chr2:200462940 T/C cg03741458 chr2:200468445 NA -0.37 -5.85 -0.31 1.18e-8 Intelligence (multi-trait analysis); CRC cis rs7659604 0.676 rs4077102 chr4:122699830 A/G cg06713675 chr4:122721982 EXOSC9 -0.52 -8.37 -0.42 1.72e-15 Type 2 diabetes; CRC cis rs600231 0.577 rs35826299 chr11:65240964 T/C cg17120908 chr11:65337727 SSSCA1 -0.68 -7.56 -0.38 4.09e-13 Bone mineral density; CRC cis rs13118159 0.771 rs13117476 chr4:1334721 A/G cg20887711 chr4:1340912 KIAA1530 0.41 5.77 0.3 1.86e-8 Longevity; CRC cis rs972578 0.837 rs5758980 chr22:43243956 T/C cg01576275 chr22:43409880 NA -0.39 -6.1 -0.32 2.95e-9 Mean platelet volume; CRC cis rs933688 1.000 rs1035477 chr5:90743325 T/C cg02339078 chr5:90679543 LOC100129716;ARRDC3 0.88 13.58 0.6 1.14e-33 Smoking behavior; CRC cis rs10751667 0.643 rs7942693 chr11:957832 G/A cg23136738 chr11:925521 AP2A2 -0.42 -7.23 -0.37 3.41e-12 Alzheimer's disease (late onset); CRC cis rs593982 0.925 rs585272 chr11:65505289 A/G cg08755490 chr11:65554678 OVOL1 1.2 18.64 0.72 2.04e-53 Atopic dermatitis; CRC cis rs1878931 0.582 rs27239 chr16:3442140 T/C cg26668626 chr16:3451006 ZNF174;ZNF434 -0.57 -6.94 -0.36 2.14e-11 Body mass index (adult); CRC trans rs3198697 1.000 rs3198697 chr16:15129940 C/T cg04146151 chr16:2155961 PKD1 -0.6 -8.07 -0.41 1.34e-14 Triglycerides; CRC cis rs4713118 0.523 rs2179096 chr6:27665920 C/T cg02683197 chr6:28174875 NA 0.61 8.77 0.44 9.69e-17 Parkinson's disease; CRC cis rs10991814 1.000 rs79808025 chr9:93953419 C/A cg14446406 chr9:93919335 NA 0.55 6.39 0.33 5.67e-10 Neutrophil percentage of granulocytes; CRC cis rs7937682 0.921 rs4534611 chr11:111440425 C/G cg09085632 chr11:111637200 PPP2R1B -0.93 -16.0 -0.66 5.1e-43 Primary sclerosing cholangitis; CRC cis rs6968419 0.755 rs1141470 chr7:115898442 G/C cg02561103 chr7:115862891 TES -0.44 -6.61 -0.34 1.58e-10 Intraocular pressure; CRC trans rs12478296 0.901 rs6731775 chr2:242999443 T/C cg18288967 chr1:45987694 PRDX1 0.63 7.35 0.38 1.57e-12 Obesity-related traits; CRC cis rs17376456 0.877 rs7734897 chr5:93305402 G/A cg25358565 chr5:93447407 FAM172A 1.05 10.89 0.51 8.72e-24 Diabetic retinopathy; CRC cis rs8031584 0.541 rs1983459 chr15:31208749 C/T cg19680485 chr15:31195859 MTMR15 -0.51 -7.28 -0.37 2.49e-12 Huntington's disease progression; CRC cis rs9549367 0.789 rs9549698 chr13:113877701 A/G cg00898013 chr13:113819073 PROZ -0.45 -6.55 -0.34 2.22e-10 Platelet distribution width; CRC cis rs9300255 0.679 rs4759420 chr12:123794871 G/C cg00376283 chr12:123451042 ABCB9 0.54 7.08 0.36 8.54e-12 Neutrophil percentage of white cells; CRC cis rs11864453 0.647 rs7194397 chr16:72128299 C/T cg23815491 chr16:72088622 HP 0.49 7.37 0.38 1.37e-12 Fibrinogen levels; CRC cis rs7586879 0.861 rs10164466 chr2:25114069 T/C cg04586622 chr2:25135609 ADCY3 -0.57 -9.76 -0.47 6.17e-20 Body mass index; CRC cis rs7615952 0.688 rs12485622 chr3:125710739 T/C cg06494592 chr3:125709126 NA -0.55 -6.72 -0.35 7.91e-11 Blood pressure (smoking interaction); CRC cis rs9916302 0.904 rs4795357 chr17:37569551 T/C cg15445000 chr17:37608096 MED1 0.42 9.14 0.45 6.65e-18 Glomerular filtration rate (creatinine); CRC cis rs7647973 0.961 rs7619016 chr3:49272589 C/T cg07636037 chr3:49044803 WDR6 0.56 6.47 0.34 3.49e-10 Menarche (age at onset); CRC cis rs9903692 0.954 rs875066 chr17:46139732 T/G cg10706073 chr17:46328419 SKAP1 -0.42 -5.68 -0.3 3.03e-8 Pulse pressure; CRC cis rs7666738 0.887 rs34509663 chr4:98982531 C/T cg05340658 chr4:99064831 C4orf37 0.51 7.22 0.37 3.6e-12 Colonoscopy-negative controls vs population controls; CRC cis rs875971 0.545 rs67397473 chr7:65633305 A/G cg18876405 chr7:65276391 NA 0.45 6.37 0.33 6.41e-10 Aortic root size; CRC cis rs3858526 0.527 rs10839168 chr11:6002798 A/G cg02574844 chr11:5959923 NA 0.35 5.64 0.3 3.64e-8 DNA methylation (variation); CRC cis rs3815700 1.000 rs3815700 chr19:33093252 T/C cg02997394 chr19:33096574 ANKRD27 0.75 8.68 0.43 1.88e-16 Eosinophilic esophagitis; CRC cis rs6840360 1.000 rs4571 chr4:152592191 T/C cg09659197 chr4:152720779 NA 0.52 10.89 0.51 8.52e-24 Intelligence (multi-trait analysis); CRC cis rs7193541 0.510 rs79473128 chr16:74589192 G/A cg01733217 chr16:74700730 RFWD3 0.76 11.92 0.55 1.74e-27 Multiple myeloma; CRC cis rs2228479 0.850 rs62052660 chr16:89847420 T/A cg06558623 chr16:89946397 TCF25 1.09 10.23 0.49 1.69e-21 Skin colour saturation; CRC cis rs9733 0.570 rs951281 chr1:150691122 A/C cg17724175 chr1:150552817 MCL1 0.57 9.12 0.45 7.76e-18 Tonsillectomy; CRC cis rs1552244 1.000 rs57631744 chr3:10118962 T/C cg16606324 chr3:10149918 C3orf24 0.7 9.74 0.47 7.03e-20 Alzheimer's disease; CRC cis rs9992667 0.664 rs112691446 chr4:38665142 G/A cg19726192 chr4:38663646 FLJ13197 -0.71 -9.02 -0.45 1.62e-17 Eosinophil percentage of granulocytes; CRC cis rs28386778 0.897 rs2727320 chr17:61865325 T/C cg22520471 chr17:61851767 DDX42;CCDC47 0.76 11.7 0.54 1.1e-26 Prudent dietary pattern; CRC cis rs3087591 0.922 rs2341348 chr17:29534867 C/T cg24425628 chr17:29625626 OMG;NF1 0.77 14.36 0.62 1.2e-36 Hip circumference; CRC cis rs12497850 0.864 rs4279134 chr3:49156676 A/G cg20833759 chr3:49053208 WDR6;DALRD3 0.46 7.62 0.39 2.81e-13 Parkinson's disease; CRC cis rs16975963 0.644 rs73035158 chr19:38141880 C/A cg15135657 chr19:38346511 NA -0.46 -6.4 -0.33 5.33e-10 Longevity; CRC cis rs67311347 1.000 rs2305522 chr3:40429358 A/G cg09455208 chr3:40491958 NA 0.44 8.94 0.44 2.81e-17 Renal cell carcinoma; CRC cis rs1065656 0.571 rs2745170 chr16:1835231 G/T cg09540102 chr16:1822124 NME3;MRPS34;EME2 0.45 6.74 0.35 7.24e-11 Insulin-like growth factors; CRC cis rs2230307 0.536 rs834277 chr1:100510855 T/G cg24955406 chr1:100503596 HIAT1 0.61 7.32 0.37 1.88e-12 Carotid intima media thickness; CRC cis rs6502050 0.835 rs4789738 chr17:80123053 G/A cg22110888 chr17:80059540 CCDC57 0.4 6.38 0.33 5.96e-10 Life satisfaction; CRC cis rs7772486 0.688 rs1884364 chr6:146337817 C/G cg13319975 chr6:146136371 FBXO30 -0.49 -6.97 -0.36 1.78e-11 Lobe attachment (rater-scored or self-reported); CRC cis rs12580194 1.000 rs7971451 chr12:55699950 G/A cg19537932 chr12:55886519 OR6C68 -0.61 -8.42 -0.42 1.18e-15 Cancer; CRC cis rs2364543 0.624 rs61774752 chr1:41847024 T/C cg08144172 chr1:41849203 NA 0.34 5.65 0.3 3.41e-8 Intelligence (multi-trait analysis); CRC cis rs7945718 0.875 rs6486057 chr11:12810338 T/A cg25843174 chr11:12811716 TEAD1 0.47 9.07 0.45 1.1e-17 Educational attainment (years of education); CRC cis rs6502050 0.777 rs6502058 chr17:80082500 A/C cg25804541 chr17:80189381 SLC16A3 0.31 5.9 0.31 8.94e-9 Life satisfaction; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg24034453 chr17:17597825 RAI1 0.44 6.19 0.32 1.82e-9 Response to antipsychotic treatment; CRC cis rs6141769 0.518 rs6057631 chr20:31319149 A/G cg13636640 chr20:31349939 DNMT3B -0.4 -5.9 -0.31 8.93e-9 Subjective well-being; CRC cis rs7178572 0.633 rs12900004 chr15:77844904 A/G cg22256960 chr15:77711686 NA -0.62 -9.22 -0.45 3.72e-18 Type 2 diabetes; CRC cis rs4731207 0.672 rs66823127 chr7:124472329 G/T cg23710748 chr7:124431027 NA 0.38 6.08 0.32 3.42e-9 Cutaneous malignant melanoma; CRC cis rs9733 0.650 rs12125672 chr1:150554470 A/T cg18016565 chr1:150552671 MCL1 -0.48 -7.19 -0.37 4.3e-12 Tonsillectomy; CRC trans rs916888 0.821 rs70602 chr17:44859715 T/C cg10053473 chr17:62856997 LRRC37A3 0.71 8.39 0.42 1.42e-15 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs67311347 1.000 rs9332450 chr3:40458041 C/T cg09455208 chr3:40491958 NA -0.44 -8.85 -0.44 5.53e-17 Renal cell carcinoma; CRC cis rs13108904 0.539 rs13141992 chr4:1340765 C/T cg02018176 chr4:1364513 KIAA1530 0.4 5.74 0.3 2.15e-8 Obesity-related traits; CRC cis rs7208859 0.623 rs11657369 chr17:29136468 G/A cg13385521 chr17:29058706 SUZ12P 0.74 8.44 0.42 9.97e-16 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs6831352 0.918 rs2851246 chr4:100046104 A/G cg12011299 chr4:100065546 ADH4 0.49 9.39 0.46 1.01e-18 Alcohol dependence; CRC cis rs10781543 0.845 rs35763810 chr9:139323799 A/G cg14019695 chr9:139328340 INPP5E 0.4 5.88 0.31 1.02e-8 Monocyte percentage of white cells; CRC trans rs61931739 0.517 rs9668303 chr12:34366701 C/T cg26384229 chr12:38710491 ALG10B 0.67 8.73 0.43 1.26e-16 Morning vs. evening chronotype; CRC cis rs250677 0.687 rs171636 chr5:148434545 G/A cg23229984 chr5:148520753 ABLIM3 0.54 7.02 0.36 1.3e-11 Breast cancer; CRC cis rs7811142 0.830 rs6975660 chr7:99975266 A/G cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.02 14.45 0.62 5.37e-37 Platelet count; CRC cis rs11764590 0.543 rs55893771 chr7:2096255 C/T cg23378565 chr7:2036160 MAD1L1 -0.4 -5.65 -0.3 3.48e-8 Neuroticism; CRC cis rs10540 0.730 rs61877766 chr11:512973 T/G cg15790184 chr11:494944 RNH1 0.61 6.24 0.33 1.35e-9 Body mass index; CRC cis rs1448094 0.512 rs7960130 chr12:86243191 T/C cg25456477 chr12:86230367 RASSF9 0.32 5.67 0.3 3.13e-8 Major depressive disorder; CRC cis rs1448094 0.511 rs61930587 chr12:86158793 T/C cg02569458 chr12:86230093 RASSF9 0.51 8.45 0.42 9.35e-16 Major depressive disorder; CRC cis rs921968 0.565 rs1554622 chr2:219606218 T/G cg02176678 chr2:219576539 TTLL4 -0.43 -6.73 -0.35 7.64e-11 Mean corpuscular hemoglobin concentration; CRC cis rs11971779 0.680 rs7783619 chr7:139061437 G/A cg07862535 chr7:139043722 LUC7L2 0.58 7.39 0.38 1.24e-12 Diisocyanate-induced asthma; CRC cis rs7020830 0.898 rs2047010 chr9:37077947 A/G cg14294708 chr9:37120828 ZCCHC7 1.18 25.47 0.81 8.58e-80 Schizophrenia; CRC trans rs116095464 0.614 rs10067482 chr5:219328 T/G cg00938859 chr5:1591904 SDHAP3 0.68 7.39 0.38 1.24e-12 Breast cancer; CRC cis rs7247513 0.701 rs8107642 chr19:12766370 C/T cg01871581 chr19:12707946 ZNF490 -0.73 -12.68 -0.57 2.75e-30 Bipolar disorder; CRC trans rs9858542 0.903 rs35999162 chr3:49597230 C/G cg21659725 chr3:3221576 CRBN -0.68 -9.19 -0.45 4.55e-18 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC trans rs951252 0.504 rs11734405 chr4:146081096 C/T cg12306414 chr4:13549355 LOC285548 0.38 6.93 0.36 2.2e-11 Hip circumference; CRC cis rs35146811 1.000 rs35146811 chr7:99720994 A/C cg03265037 chr7:99691720 MIR25;MCM7;MIR106B;MIR93 0.45 5.67 0.3 3.06e-8 Coronary artery disease; CRC trans rs1035491 0.720 rs10940001 chr5:63960187 C/T cg08645400 chr16:49307062 NA 0.35 6.18 0.32 1.88e-9 Body mass index; CRC cis rs6496667 0.779 rs2283441 chr15:90970781 G/A cg04176472 chr15:90893244 GABARAPL3 0.6 8.46 0.42 8.66e-16 Rheumatoid arthritis; CRC trans rs10028773 0.700 rs7690338 chr4:120256468 C/G cg25214090 chr10:38739885 LOC399744 0.54 8.52 0.43 5.9e-16 Educational attainment; CRC cis rs6952808 0.564 rs73038441 chr7:2139286 T/C cg04267008 chr7:1944627 MAD1L1 -0.67 -9.28 -0.46 2.28e-18 Bipolar disorder and schizophrenia; CRC cis rs4481887 0.741 rs11488133 chr1:248548380 T/C cg00666640 chr1:248458726 OR2T12 0.39 7.18 0.37 4.69e-12 Common traits (Other); CRC cis rs1799949 0.965 rs11650132 chr17:41326087 T/G cg25072359 chr17:41440525 NA 0.44 6.45 0.33 4.09e-10 Menopause (age at onset); CRC cis rs10208940 0.614 rs7569174 chr2:68735336 G/T cg12452813 chr2:68675892 NA 0.47 5.81 0.31 1.44e-8 Urate levels in lean individuals; CRC cis rs875971 0.522 rs4502988 chr7:65297746 A/G cg11764359 chr7:65958608 NA 0.51 7.72 0.39 1.44e-13 Aortic root size; CRC trans rs9858542 1.000 rs6770670 chr3:49686682 T/C cg21659725 chr3:3221576 CRBN -0.71 -9.51 -0.46 4.13e-19 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs939584 1.000 rs7561317 chr2:644953 A/G cg03610516 chr2:642275 NA 0.41 5.71 0.3 2.51e-8 Body mass index; CRC trans rs17685 0.725 rs7807647 chr7:75628669 G/A cg19862616 chr7:65841803 NCRNA00174 -0.97 -18.06 -0.71 3.7e-51 Coffee consumption;Coffee consumption (cups per day); CRC cis rs4713118 0.869 rs9461400 chr6:27700559 A/G cg03623178 chr6:28175578 NA 0.66 9.34 0.46 1.46e-18 Parkinson's disease; CRC cis rs2425143 0.908 rs6060625 chr20:34414318 C/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.51 -6.12 -0.32 2.73e-9 Blood protein levels; CRC cis rs9611565 0.879 rs5758307 chr22:41750219 A/G cg06634786 chr22:41940651 POLR3H -0.44 -5.92 -0.31 8.23e-9 Vitiligo; CRC cis rs1153858 1.000 rs7164602 chr15:45671325 A/G cg21132104 chr15:45694354 SPATA5L1 0.59 8.56 0.43 4.47e-16 Homoarginine levels; CRC cis rs61612642 0.590 rs6931028 chr6:42193064 A/T cg10382835 chr6:42185730 MRPS10 0.66 6.5 0.34 2.92e-10 Eosinophil percentage of white cells;Sum eosinophil basophil counts;Eosinophil percentage of granulocytes;Eosinophil counts; CRC cis rs863345 0.604 rs12041350 chr1:158482048 A/G cg12129480 chr1:158549410 OR10X1 -0.3 -6.29 -0.33 1.04e-9 Pneumococcal bacteremia; CRC cis rs4713118 0.826 rs2893929 chr6:27738732 A/T cg12172441 chr6:28176163 NA 0.6 6.56 0.34 2.1e-10 Parkinson's disease; CRC cis rs1008375 1.000 rs11722037 chr4:17683811 G/A cg16339924 chr4:17578868 LAP3 0.53 7.08 0.36 8.64e-12 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs55871839 0.708 rs13263261 chr8:59814688 T/G cg07426533 chr8:59803705 TOX -0.34 -5.94 -0.31 7.16e-9 Pneumonia; CRC cis rs12594515 0.967 rs67854274 chr15:45990518 A/G cg01629716 chr15:45996671 NA 0.41 8.46 0.42 9.03e-16 Waist circumference;Weight; CRC cis rs7412746 0.611 rs9661876 chr1:150910911 C/T cg10589385 chr1:150898437 SETDB1 0.27 5.92 0.31 7.89e-9 Melanoma; CRC cis rs853679 0.517 rs9380056 chr6:28104476 C/T cg03623178 chr6:28175578 NA 0.96 12.57 0.57 7.23e-30 Depression; CRC cis rs35160687 0.814 rs6547673 chr2:86528938 A/G cg10973622 chr2:86423274 IMMT 0.27 5.61 0.3 4.27e-8 Night sleep phenotypes; CRC cis rs10911232 0.507 rs10797819 chr1:183006911 A/G ch.1.3577855R chr1:183094577 LAMC1 0.85 14.9 0.63 1.01e-38 Hypertriglyceridemia; CRC cis rs2032447 0.507 rs199741 chr6:25931577 A/G cg12310025 chr6:25882481 NA -0.84 -11.95 -0.55 1.34e-27 Intelligence (multi-trait analysis); CRC cis rs875971 0.545 rs1065265 chr7:65841203 C/T cg03233332 chr7:66118400 NA -0.43 -5.87 -0.31 1.05e-8 Aortic root size; CRC cis rs6570726 0.935 rs413916 chr6:145831400 T/C cg23711669 chr6:146136114 FBXO30 0.68 12.07 0.55 4.98e-28 Lobe attachment (rater-scored or self-reported); CRC cis rs7811142 1.000 rs76913697 chr7:100002772 A/G cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.13 16.78 0.68 4.33e-46 Platelet count; CRC cis rs10791097 0.642 rs7107568 chr11:130779668 T/C cg12179176 chr11:130786555 SNX19 0.82 14.59 0.63 1.64e-37 Autism spectrum disorder or schizophrenia;Schizophrenia; CRC cis rs6499255 0.903 rs1800566 chr16:69745145 C/T cg04110750 chr16:69646130 NFAT5 -0.58 -7.98 -0.4 2.46e-14 IgE levels; CRC cis rs4654899 0.897 rs7515308 chr1:21085653 G/C cg02927042 chr1:21476669 EIF4G3 -0.43 -6.7 -0.35 9.19e-11 Superior frontal gyrus grey matter volume; CRC cis rs796364 0.806 rs188102 chr2:200903189 T/A cg12253985 chr2:200820533 C2orf60;C2orf47 -0.57 -5.62 -0.3 4.18e-8 Schizophrenia; CRC trans rs60843830 1.000 rs57542652 chr2:228088 G/A cg11347411 chr7:150020925 ACTR3C;LRRC61 0.61 9.39 0.46 1.05e-18 Spherical equivalent (joint analysis main effects and education interaction); CRC cis rs561341 0.941 rs8066156 chr17:30361629 A/G cg23018236 chr17:30244563 NA -0.45 -6.09 -0.32 3.17e-9 Hip circumference adjusted for BMI; CRC cis rs9322193 0.847 rs12210605 chr6:150138403 A/G cg00933542 chr6:150070202 PCMT1 0.31 5.84 0.31 1.23e-8 Lung cancer; CRC cis rs7208859 0.623 rs58908911 chr17:29244558 C/T cg14008862 chr17:28927542 LRRC37B2 0.56 5.82 0.31 1.42e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs10504229 1.000 rs78953746 chr8:58170608 A/G cg22535103 chr8:58192502 C8orf71 -0.82 -12.26 -0.56 1.03e-28 Developmental language disorder (linguistic errors); CRC cis rs4474465 0.850 rs10793329 chr11:78265655 G/C cg27205649 chr11:78285834 NARS2 0.51 6.59 0.34 1.77e-10 Alzheimer's disease (survival time); CRC cis rs7772486 0.764 rs2265471 chr6:146220250 G/A cg23711669 chr6:146136114 FBXO30 0.72 12.79 0.58 1.13e-30 Lobe attachment (rater-scored or self-reported); CRC cis rs6728642 0.519 rs4260285 chr2:97570081 A/G cg26665480 chr2:98280029 ACTR1B -0.55 -5.96 -0.31 6.47e-9 Bipolar disorder lithium response (continuous) or schizophrenia; CRC cis rs477895 0.653 rs12797120 chr11:63906819 C/T cg05016508 chr11:63871570 FLRT1;MACROD1 0.53 6.83 0.35 4.22e-11 Mean platelet volume; CRC cis rs59104589 0.550 rs62193172 chr2:242277715 G/C cg19488206 chr2:242435732 STK25 0.47 6.66 0.34 1.18e-10 Fibrinogen levels; CRC cis rs3741151 0.773 rs79915238 chr11:73272947 C/T cg17517138 chr11:73019481 ARHGEF17 0.96 7.44 0.38 8.7e-13 GIP levels in response to oral glucose tolerance test (120 minutes); CRC trans rs3749237 1.000 rs11920900 chr3:49823024 G/C cg21665057 chr3:196295764 WDR53;FBXO45 0.51 6.94 0.36 2.07e-11 Resting heart rate; CRC cis rs10771431 0.782 rs10771415 chr12:9358223 C/T cg08997352 chr12:9597637 DDX12 -0.51 -7.96 -0.4 2.8e-14 Breast size; CRC cis rs9875589 0.957 rs1108341 chr3:13937328 T/A cg14375111 chr3:14165186 TMEM43;CHCHD4 -0.39 -5.6 -0.3 4.51e-8 Ovarian reserve; CRC cis rs9308731 0.644 rs3789065 chr2:111915022 C/G cg18646521 chr2:111875858 NA 0.38 6.04 0.32 4.23e-9 Chronic lymphocytic leukemia; CRC trans rs9929218 0.529 rs17715450 chr16:68729785 C/A cg04657470 chr2:198365150 HSPE1;HSPD1 0.99 18.55 0.71 4.52e-53 Colorectal cancer; CRC cis rs4713118 0.869 rs6930992 chr6:27712120 A/C cg15786705 chr6:28176104 NA 0.54 7.62 0.39 2.72e-13 Parkinson's disease; CRC cis rs17780086 0.527 rs72827712 chr17:30538600 A/G cg19193384 chr17:30244184 NA -0.6 -6.01 -0.31 4.96e-9 Height; CRC trans rs10802346 0.545 rs1770012 chr1:246426405 A/G cg22732515 chr19:44031385 ETHE1 0.7 10.69 0.51 4.19e-23 Fractional exhaled nitric oxide (childhood); CRC cis rs2841277 0.738 rs1036713 chr14:105396693 C/G cg14403583 chr14:105418241 AHNAK2 0.35 6.12 0.32 2.71e-9 Rheumatoid arthritis; CRC cis rs11997175 0.511 rs4613957 chr8:33673130 C/T cg04338863 chr8:33670619 NA -0.38 -6.43 -0.33 4.43e-10 Body mass index; CRC cis rs1656402 0.906 rs1656401 chr2:233426601 A/G cg03852847 chr2:233439513 NA 0.45 7.66 0.39 2.1e-13 Non-small cell lung cancer (survival); CRC cis rs11229555 0.645 rs34350060 chr11:58184902 T/C cg15696309 chr11:58395628 NA -0.81 -10.31 -0.49 8.83e-22 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; CRC cis rs9487051 0.837 rs9480920 chr6:109605322 C/A cg01475377 chr6:109611718 NA -0.49 -9.22 -0.45 3.54e-18 Reticulocyte fraction of red cells; CRC cis rs2463822 0.858 rs2513037 chr11:62084822 A/T cg06239285 chr11:62104954 ASRGL1 -0.93 -11.3 -0.53 2.98e-25 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs6502050 0.805 rs6502061 chr17:80086158 C/T cg13198984 chr17:80129470 CCDC57 -0.46 -7.97 -0.4 2.65e-14 Life satisfaction; CRC cis rs6700896 0.897 rs28480230 chr1:66124075 C/T cg04111102 chr1:66153794 NA 0.34 5.94 0.31 7.36e-9 C-reactive protein;Mean corpuscular volume;Mean corpuscular hemoglobin; CRC cis rs736408 0.609 rs13061423 chr3:52790213 T/C cg08222913 chr3:52553049 STAB1 -0.34 -6.21 -0.32 1.63e-9 Bipolar disorder; CRC cis rs55692411 0.537 rs13071931 chr3:50062878 G/A cg05623727 chr3:50126028 RBM5 0.51 6.51 0.34 2.76e-10 Intelligence (multi-trait analysis); CRC cis rs4689388 0.853 rs1079216 chr4:6282473 T/C cg25554036 chr4:6271136 WFS1 0.54 8.69 0.43 1.79e-16 Type 2 diabetes and other traits;Type 2 diabetes; CRC cis rs9914988 0.778 rs35398767 chr17:27122960 A/T cg07195577 chr17:27052828 TLCD1 0.42 6.02 0.32 4.64e-9 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs4731207 0.623 rs719973 chr7:124631727 G/A cg23710748 chr7:124431027 NA -0.39 -6.34 -0.33 7.73e-10 Cutaneous malignant melanoma; CRC trans rs11654801 0.812 rs9914432 chr17:20857356 T/C cg23759823 chr7:139672531 TBXAS1 -0.4 -6.41 -0.33 5.1e-10 Mosquito bite size; CRC trans rs7267979 0.966 rs8123949 chr20:25388133 C/T cg17903999 chr18:56338584 MALT1 0.41 6.89 0.36 2.76e-11 Liver enzyme levels (alkaline phosphatase); CRC cis rs11628318 0.614 rs7155804 chr14:103114945 A/G cg23461800 chr14:103021989 NA 0.69 7.76 0.39 1.08e-13 Platelet count; CRC cis rs589448 0.933 rs523398 chr12:69752775 C/T cg22834771 chr12:69754056 YEATS4 -0.56 -8.73 -0.43 1.33e-16 Cerebrospinal fluid biomarker levels; CRC cis rs10504229 0.683 rs2005392 chr8:58106896 T/C cg04204079 chr8:58130323 NA -0.46 -5.79 -0.3 1.67e-8 Developmental language disorder (linguistic errors); CRC cis rs34779708 0.931 rs4934711 chr10:35360310 G/A cg03585969 chr10:35415529 CREM 0.57 7.65 0.39 2.26e-13 Inflammatory bowel disease;Crohn's disease; CRC cis rs12541635 0.966 rs12681183 chr8:107007156 T/A cg10147462 chr8:107024639 NA 0.42 6.92 0.36 2.42e-11 Age of smoking initiation; CRC cis rs6089584 0.816 rs6061410 chr20:60625329 A/G cg18761221 chr20:60518478 NA 0.48 7.82 0.4 7.11e-14 Body mass index; CRC cis rs780094 0.544 rs2303370 chr2:27651375 C/T cg24768116 chr2:27665128 KRTCAP3 -0.33 -7.52 -0.38 5.11e-13 Calcium levels;Fasting blood insulin;Metabolic traits;Triglyceride levels;Fasting plasma glucose;Urate levels in overweight individuals;Urate levels in obese individuals;Uric acid levels;Height;Age-related diseases, mortality and associated endophenotypes;Renal underexcretion gout;Fasting blood glucose (BMI interaction);Urate levels;Gondoic acid (20:1n-9) levels;Fasting blood insulin (BMI interaction);Triglycerides;Plasma omega-3 polyunsaturated fatty acid levels (docosapentaenoic acid);Type 2 diabetes;Nonalcoholic fatty liver disease;Hypertriglyceridemia;C-reactive protein;Age-related disease endophenotypes;LDL cholesterol;Metabolic syndrome;Crohn's disease;Alcohol consumption (drinks per week);Homeostasis model assessment of insulin resistance;Alcohol consumption;Red blood cell count;Fasting blood glucose; CRC cis rs6951245 0.744 rs1133122 chr7:1192572 C/A cg04025307 chr7:1156635 C7orf50 0.65 7.37 0.38 1.39e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs11785400 0.701 rs9721143 chr8:143727511 A/T cg10596483 chr8:143751796 JRK 0.47 6.37 0.33 6.37e-10 Schizophrenia; CRC cis rs7605827 0.930 rs3815597 chr2:15625404 T/C cg19274914 chr2:15703543 NA 0.39 6.01 0.31 5e-9 Educational attainment (years of education); CRC cis rs2108622 0.527 rs67617968 chr19:15977565 A/G cg13772218 chr19:15982569 NA 0.39 5.66 0.3 3.22e-8 Circulating phylloquinone levels;Vitamin E levels;Acenocoumarol maintenance dosage;Response to Vitamin E supplementation;Metabolite levels;Warfarin maintenance dose; CRC cis rs7703744 0.634 rs6884061 chr5:118683431 C/T cg17471836 chr5:118691007 TNFAIP8 0.45 6.46 0.34 3.66e-10 Lobe attachment (rater-scored or self-reported); CRC cis rs6502050 0.777 rs4625783 chr17:80086395 T/C cg22110888 chr17:80059540 CCDC57 -0.41 -6.39 -0.33 5.57e-10 Life satisfaction; CRC cis rs11098499 0.820 rs6829903 chr4:120506884 C/T cg09307838 chr4:120376055 NA 0.68 10.13 0.49 3.68e-21 Corneal astigmatism; CRC trans rs57221529 0.766 rs28563961 chr5:554498 C/G cg11887960 chr12:57824829 NA 0.6 6.48 0.34 3.28e-10 Lung disease severity in cystic fibrosis; CRC cis rs926938 0.563 rs360645 chr1:115427218 A/G cg12756093 chr1:115239321 AMPD1 0.57 8.52 0.42 6.02e-16 Autism; CRC trans rs208515 0.525 rs12204706 chr6:66669930 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.88 -11.17 -0.52 8.64e-25 Exhaled nitric oxide levels; CRC cis rs17065868 0.764 rs12146917 chr13:45035759 T/A cg10246903 chr13:45222710 NA 0.54 5.69 0.3 2.79e-8 Antineutrophil cytoplasmic antibody-associated vasculitis; CRC cis rs929354 0.772 rs4716460 chr7:156970054 T/C cg17757837 chr7:157058334 UBE3C 0.74 12.39 0.56 3.31e-29 Body mass index; CRC cis rs3749237 0.557 rs7631908 chr3:49425707 T/G cg07636037 chr3:49044803 WDR6 0.55 8.1 0.41 1.08e-14 Resting heart rate; CRC trans rs4650994 1.000 rs4354501 chr1:178524596 T/C cg05059571 chr16:84539110 KIAA1609 -0.45 -6.84 -0.35 3.76e-11 HDL cholesterol levels;HDL cholesterol; CRC cis rs3733585 0.746 rs4318650 chr4:10016868 T/C cg11266682 chr4:10021025 SLC2A9 0.54 11.08 0.52 1.79e-24 Cleft plate (environmental tobacco smoke interaction); CRC cis rs9733 0.650 rs12406712 chr1:150545084 C/A cg17724175 chr1:150552817 MCL1 -0.52 -8.42 -0.42 1.16e-15 Tonsillectomy; CRC trans rs9825823 0.617 rs2083264 chr3:61074229 A/G cg01801182 chr1:46998715 NA 0.34 5.97 0.31 6.16e-9 Depressive symptom measurement or major depressive disorder; CRC trans rs701145 0.556 rs355762 chr3:154012614 G/A cg22545385 chr10:131989303 NA -0.42 -6.05 -0.32 3.99e-9 Coronary artery disease; CRC cis rs4664293 0.625 rs62171641 chr2:160516505 G/A cg08347373 chr2:160653686 CD302 0.39 6.58 0.34 1.91e-10 Monocyte percentage of white cells; CRC cis rs763121 0.853 rs5750626 chr22:38977890 G/C cg06544989 chr22:39130855 UNC84B 0.44 6.41 0.33 5.17e-10 Menopause (age at onset); CRC trans rs3749237 1.000 rs6804655 chr3:49738945 C/T cg21665057 chr3:196295764 WDR53;FBXO45 0.56 7.81 0.4 7.88e-14 Resting heart rate; CRC cis rs1971762 0.527 rs784568 chr12:53927554 C/A cg06632207 chr12:54070931 ATP5G2 -0.49 -8.28 -0.42 3.18e-15 Height; CRC cis rs11785400 0.793 rs4736364 chr8:143742113 C/T cg24634471 chr8:143751801 JRK 0.52 7.21 0.37 3.82e-12 Schizophrenia; CRC trans rs56114371 0.777 rs200483 chr6:27774824 C/T cg06606381 chr12:133084897 FBRSL1 -0.77 -6.68 -0.35 1.05e-10 Breast cancer; CRC cis rs780096 0.526 rs10182937 chr2:27651693 T/C cg22903471 chr2:27725779 GCKR -0.36 -5.9 -0.31 9.13e-9 Total body bone mineral density; CRC cis rs977987 0.843 rs59465235 chr16:75483810 C/G cg03315344 chr16:75512273 CHST6 0.53 9.08 0.45 1e-17 Dupuytren's disease; CRC cis rs4253772 0.530 rs9615958 chr22:46751122 A/G cg24881330 chr22:46731750 TRMU 0.69 6.63 0.34 1.36e-10 LDL cholesterol;Cholesterol, total; CRC cis rs4664293 1.000 rs10184034 chr2:160505427 A/G cg08347373 chr2:160653686 CD302 -0.38 -6.24 -0.33 1.38e-9 Monocyte percentage of white cells; CRC cis rs7914558 0.899 rs7913682 chr10:104684392 T/A cg15744005 chr10:104629667 AS3MT -0.36 -7.63 -0.39 2.48e-13 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs425277 0.917 rs262656 chr1:2088754 A/C cg24578937 chr1:2090814 PRKCZ 0.66 11.79 0.54 5.41e-27 Height; CRC cis rs1707322 1.000 rs6672115 chr1:46272879 T/C cg06784218 chr1:46089804 CCDC17 0.59 10.69 0.51 4.17e-23 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs4700695 0.764 rs10066817 chr5:65319853 A/G cg21114390 chr5:65439923 SFRS12 0.57 6.99 0.36 1.58e-11 Facial morphology (factor 19); CRC cis rs17666538 0.535 rs1669658 chr8:607380 A/G cg07234876 chr8:600039 NA 0.81 7.36 0.38 1.51e-12 IgG glycosylation; CRC cis rs2976388 0.556 rs10956985 chr8:143818750 C/A cg24046110 chr8:143859143 LYNX1 -0.43 -6.55 -0.34 2.2e-10 Urinary tract infection frequency; CRC cis rs2952156 1.000 rs2643195 chr17:37853118 A/G cg00129232 chr17:37814104 STARD3 -0.71 -12.02 -0.55 7.44e-28 Asthma; CRC cis rs10463316 0.817 rs6895187 chr5:150775909 G/A cg03212797 chr5:150827313 SLC36A1 -0.49 -7.82 -0.4 7.31e-14 Metabolite levels (Pyroglutamine); CRC trans rs2189609 0.521 rs2526066 chr16:74037837 A/C cg17226575 chr8:90914282 OSGIN2 -0.43 -6.08 -0.32 3.24e-9 Energy expenditure (24h); CRC cis rs9463078 0.774 rs7740083 chr6:45274742 G/A cg25276700 chr6:44698697 NA -0.28 -6.77 -0.35 5.75e-11 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; CRC trans rs3733585 0.673 rs7376505 chr4:9952744 C/A cg26043149 chr18:55253948 FECH -0.5 -7.71 -0.39 1.51e-13 Cleft plate (environmental tobacco smoke interaction); CRC cis rs2408955 0.522 rs4760612 chr12:48421856 C/T cg21466736 chr12:48725269 NA 0.47 7.17 0.37 5.03e-12 Glycated hemoglobin levels; CRC trans rs3942852 0.545 rs7395231 chr11:48091689 T/C cg15704280 chr7:45808275 SEPT13 -0.68 -9.65 -0.47 1.43e-19 Acute lymphoblastic leukemia (childhood); CRC cis rs6952808 1.000 rs6952808 chr7:1886535 C/G cg02951883 chr7:2050386 MAD1L1 -0.63 -10.07 -0.49 5.66e-21 Bipolar disorder and schizophrenia; CRC cis rs977987 0.806 rs4638613 chr16:75425553 C/T cg03315344 chr16:75512273 CHST6 0.51 8.63 0.43 2.68e-16 Dupuytren's disease; CRC cis rs4660214 0.568 rs6692769 chr1:39683175 G/C cg11070191 chr1:39582205 MACF1 0.36 5.77 0.3 1.86e-8 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs4853012 0.887 rs77148265 chr2:74339519 C/T cg01017244 chr2:74357527 NA 0.66 8.64 0.43 2.54e-16 Gestational age at birth (maternal effect); CRC cis rs2742417 0.967 rs2742426 chr3:45735901 A/G cg04837898 chr3:45731254 SACM1L -0.34 -5.61 -0.3 4.36e-8 Response to anti-depressant treatment in major depressive disorder; CRC cis rs6665290 0.669 rs3795446 chr1:227180981 C/T cg10327440 chr1:227177885 CDC42BPA 0.97 19.76 0.74 7.37e-58 Myeloid white cell count; CRC cis rs1129187 0.755 rs9462856 chr6:42926024 T/C cg05552183 chr6:42928497 GNMT 0.52 7.84 0.4 6.21e-14 Alzheimer's disease in APOE e4+ carriers; CRC cis rs10540 1.000 rs78520676 chr11:517173 G/A cg03352830 chr11:487213 PTDSS2 0.65 7.41 0.38 1.09e-12 Body mass index; CRC cis rs7618915 0.571 rs67539070 chr3:52711974 T/C cg08222913 chr3:52553049 STAB1 -0.34 -6.23 -0.32 1.45e-9 Bipolar disorder; CRC cis rs4731207 0.596 rs12055904 chr7:124662864 C/T cg23710748 chr7:124431027 NA -0.39 -6.19 -0.32 1.77e-9 Cutaneous malignant melanoma; CRC cis rs4604732 0.631 rs34924545 chr1:247626892 G/T cg12758973 chr1:247694275 LOC148824;OR2C3 0.42 6.21 0.32 1.63e-9 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CRC cis rs9814567 1.000 rs7428326 chr3:134251184 A/G cg06109529 chr3:134205091 CEP63;ANAPC13 -0.81 -12.19 -0.56 1.92e-28 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs4862750 0.914 rs11943333 chr4:187872455 A/G cg11301795 chr4:187892539 NA -0.79 -16.14 -0.66 1.48e-43 Lobe attachment (rater-scored or self-reported); CRC cis rs4665809 0.590 rs6716858 chr2:26423414 G/A cg04944784 chr2:26401820 FAM59B -0.72 -9.85 -0.48 3.12e-20 Gut microbiome composition (summer); CRC cis rs7937682 1.000 rs9734135 chr11:111536190 G/A cg19812747 chr11:111475976 SIK2 -0.56 -9.53 -0.46 3.7e-19 Primary sclerosing cholangitis; CRC cis rs4742903 0.967 rs10125661 chr9:106868443 A/G cg14250997 chr9:106856677 SMC2 0.38 5.72 0.3 2.39e-8 High-grade serous ovarian cancer;Breast cancer; CRC cis rs4555082 0.957 rs2816608 chr14:105718407 A/G cg06808227 chr14:105710500 BRF1 0.59 9.23 0.45 3.46e-18 Mean platelet volume;Platelet distribution width; CRC cis rs3733585 0.781 rs57250714 chr4:9984529 C/T cg11266682 chr4:10021025 SLC2A9 0.46 9.08 0.45 1.01e-17 Cleft plate (environmental tobacco smoke interaction); CRC cis rs3087591 1.000 rs2952978 chr17:29474744 A/C cg24425628 chr17:29625626 OMG;NF1 0.86 15.89 0.66 1.36e-42 Hip circumference; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg02738677 chr3:133265129 NA -0.4 -6.19 -0.32 1.79e-9 Liver disease severity in Alagille syndrome; CRC cis rs13256369 0.708 rs10903310 chr8:8589687 A/C cg00074818 chr8:8560427 CLDN23 -0.39 -7.1 -0.36 7.73e-12 Obesity-related traits; CRC cis rs7666738 0.791 rs34088022 chr4:99001508 G/T cg05340658 chr4:99064831 C4orf37 0.61 9.54 0.47 3.44e-19 Colonoscopy-negative controls vs population controls; CRC cis rs4819052 0.819 rs8134084 chr21:46693295 G/A cg02159808 chr21:46707872 POFUT2;LOC642852 0.51 6.71 0.35 8.75e-11 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs853679 0.550 rs1233699 chr6:28169158 A/T cg06470822 chr6:28175283 NA 1.04 16.0 0.66 4.91e-43 Depression; CRC cis rs6586163 0.872 rs7082720 chr10:90742049 C/T cg03111039 chr10:90751583 FAS;ACTA2 -0.5 -7.08 -0.36 8.67e-12 Chronic lymphocytic leukemia; CRC cis rs10504229 0.906 rs59336968 chr8:58176857 T/C cg02290350 chr8:58132656 NA -0.42 -5.96 -0.31 6.62e-9 Developmental language disorder (linguistic errors); CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg18043075 chr10:115933939 MIR2110;C10orf118 0.45 6.24 0.33 1.36e-9 Anxiety disorder; CRC cis rs9291683 0.609 rs12507050 chr4:10007305 G/T cg11266682 chr4:10021025 SLC2A9 0.55 11.65 0.54 1.78e-26 Bone mineral density; CRC cis rs8141529 0.702 rs132536 chr22:29302906 A/G cg02153584 chr22:29168773 CCDC117 -0.48 -7.07 -0.36 9.05e-12 Lymphocyte counts; CRC cis rs7615952 0.641 rs2365019 chr3:125808135 T/C cg06494592 chr3:125709126 NA -0.58 -6.85 -0.35 3.57e-11 Blood pressure (smoking interaction); CRC cis rs1129187 0.755 rs9462856 chr6:42926024 T/C cg26304593 chr6:42947056 PEX6 -0.44 -6.25 -0.33 1.26e-9 Alzheimer's disease in APOE e4+ carriers; CRC cis rs847577 0.572 rs847573 chr7:97681761 C/T cg21770322 chr7:97807741 LMTK2 -0.56 -8.3 -0.42 2.78e-15 Breast cancer; CRC cis rs11123610 0.520 rs7576701 chr2:3718227 T/C cg19052272 chr2:3704530 ALLC -0.62 -7.69 -0.39 1.68e-13 Response to inhaled corticosteroid treatment in asthma (change in FEV1); CRC cis rs60871478 0.704 rs62432895 chr7:822050 C/G cg05535760 chr7:792225 HEATR2 0.82 11.02 0.52 3.07e-24 Cerebrospinal P-tau181p levels; CRC cis rs4594175 0.926 rs10138345 chr14:51624651 A/G cg23942311 chr14:51606299 NA 0.64 9.71 0.47 9.35e-20 Cancer; CRC cis rs896854 0.653 rs13266313 chr8:95975302 C/T cg23172400 chr8:95962367 TP53INP1 -0.49 -8.19 -0.41 5.96e-15 Type 2 diabetes; CRC cis rs7727544 0.716 rs72793278 chr5:131561372 C/A cg18301423 chr5:131593218 PDLIM4 0.31 5.68 0.3 2.9e-8 Blood metabolite levels; CRC cis rs734999 0.588 rs3001837 chr1:2532506 G/A cg18854424 chr1:2615690 NA -0.42 -8.05 -0.41 1.56e-14 Ulcerative colitis; CRC cis rs72730918 0.590 rs1378894 chr15:51937462 G/A cg14296394 chr15:51910925 DMXL2 -0.47 -6.32 -0.33 8.69e-10 Intelligence (multi-trait analysis); CRC cis rs2404618 0.593 rs7815979 chr8:1484887 A/G cg02903104 chr8:1507517 DLGAP2 0.42 8.04 0.41 1.6e-14 Lung cancer; CRC cis rs35306767 0.855 rs11253459 chr10:886402 C/T cg20503657 chr10:835505 NA 0.88 11.07 0.52 2.05e-24 Eosinophil percentage of granulocytes; CRC cis rs11122272 0.701 rs2790894 chr1:231505587 T/A cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.52 -7.69 -0.39 1.68e-13 Hemoglobin concentration; CRC cis rs356992 0.957 rs356993 chr2:60750560 C/T cg08426369 chr2:60753602 BCL11A -0.55 -7.55 -0.38 4.3e-13 Educational attainment (years of education); CRC cis rs7412746 0.658 rs6658066 chr1:150918937 T/G cg17724175 chr1:150552817 MCL1 0.4 6.19 0.32 1.75e-9 Melanoma; CRC cis rs3820068 0.581 rs59684759 chr1:15919893 A/G cg27534772 chr1:16042836 PLEKHM2 0.53 10.03 0.48 7.59e-21 Systolic blood pressure; CRC cis rs60871478 0.947 rs62432255 chr7:804219 G/A cg13844804 chr7:814759 HEATR2 0.65 8.47 0.42 8.48e-16 Cerebrospinal P-tau181p levels; CRC cis rs11711311 0.911 rs34337798 chr3:113396704 C/T cg15478005 chr3:113465772 ATP6V1A;NAA50 0.46 6.24 0.33 1.35e-9 IgG glycosylation; CRC cis rs425277 0.606 rs16824792 chr1:2039521 G/T cg03732007 chr1:2071316 PRKCZ -0.36 -5.75 -0.3 2e-8 Height; CRC cis rs4332037 0.539 rs55993248 chr7:2071132 A/G cg24505167 chr7:1915268 MAD1L1 -0.4 -5.62 -0.3 4.18e-8 Bipolar disorder; CRC cis rs875971 1.000 rs1363055 chr7:65943275 A/G cg12463550 chr7:65579703 CRCP 0.48 6.78 0.35 5.54e-11 Aortic root size; CRC cis rs1003719 0.843 rs1003721 chr21:38492657 T/G cg10648535 chr21:38446584 PIGP;TTC3 0.44 6.16 0.32 2.06e-9 Eye color traits; CRC cis rs1165205 0.558 rs531750 chr6:25882642 C/G cg03264133 chr6:25882463 NA -0.88 -13.85 -0.61 1.13e-34 Urate levels; CRC cis rs8141529 0.956 rs469989 chr22:29303595 G/C cg02153584 chr22:29168773 CCDC117 -0.43 -6.0 -0.31 5.3300000000000004e-09 Lymphocyte counts; CRC cis rs4713118 0.955 rs9380011 chr6:27683924 A/G cg15786705 chr6:28176104 NA 0.48 6.42 0.33 4.89e-10 Parkinson's disease; CRC cis rs6879260 0.963 rs1035412 chr5:179729328 C/T cg02891314 chr5:179741120 GFPT2 -0.69 -10.82 -0.51 1.53e-23 Height; CRC cis rs9611565 0.765 rs28604950 chr22:41785812 A/G cg06481639 chr22:41940642 POLR3H -0.52 -6.04 -0.32 4.2e-9 Vitiligo; CRC cis rs10463316 0.894 rs7712569 chr5:150766089 A/C cg03212797 chr5:150827313 SLC36A1 -0.49 -7.76 -0.39 1.06e-13 Metabolite levels (Pyroglutamine); CRC cis rs17767392 1.000 rs34746156 chr14:71752360 A/T cg13720639 chr14:72061746 SIPA1L1 -0.53 -6.68 -0.35 1e-10 Mitral valve prolapse; CRC cis rs55665837 0.524 rs61884009 chr11:14426462 C/T cg19336497 chr11:14380999 RRAS2 -0.45 -7.5 -0.38 6.15e-13 Vitamin D levels; CRC cis rs734999 0.545 rs28532547 chr1:2561286 T/G cg18854424 chr1:2615690 NA -0.38 -7.23 -0.37 3.34e-12 Ulcerative colitis; CRC cis rs1129187 0.755 rs9462856 chr6:42926024 T/C cg10862848 chr6:42927986 GNMT -0.38 -8.93 -0.44 3.04e-17 Alzheimer's disease in APOE e4+ carriers; CRC cis rs1707322 1.000 rs4074225 chr1:46392364 G/C cg06784218 chr1:46089804 CCDC17 0.59 10.69 0.51 4.15e-23 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC trans rs11148252 0.875 rs9568728 chr13:52946593 C/T cg18335740 chr13:41363409 SLC25A15 0.5 7.84 0.4 6.23e-14 Lewy body disease; CRC cis rs7927592 0.913 rs7118897 chr11:68360680 G/A cg01657329 chr11:68192670 LRP5 -0.48 -6.98 -0.36 1.65e-11 Total body bone mineral density; CRC cis rs6951245 0.872 rs77569514 chr7:1085508 G/A cg04025307 chr7:1156635 C7orf50 0.64 6.69 0.35 9.78e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC trans rs3960554 0.808 rs78478514 chr7:75655896 C/T cg19862616 chr7:65841803 NCRNA00174 0.69 8.09 0.41 1.15e-14 Eotaxin levels; CRC cis rs780096 0.565 rs813592 chr2:27721971 T/C cg17158414 chr2:27665306 KRTCAP3 -0.27 -6.08 -0.32 3.29e-9 Total body bone mineral density; CRC cis rs2346177 0.875 rs12986585 chr2:46644121 T/A cg26688816 chr2:46740690 ATP6V1E2 -0.5 -8.03 -0.4 1.73e-14 HDL cholesterol; CRC cis rs6570726 0.791 rs378937 chr6:145834745 C/T cg23711669 chr6:146136114 FBXO30 0.74 12.9 0.58 4.48e-31 Lobe attachment (rater-scored or self-reported); CRC cis rs11155671 0.530 rs7742993 chr6:150205095 G/A cg19673125 chr6:150240577 RAET1G 0.3 5.85 0.31 1.17e-8 Testicular germ cell tumor; CRC cis rs11599315 0.757 rs11250392 chr10:1342543 T/C cg09624528 chr10:1369823 ADARB2 0.43 6.12 0.32 2.61e-9 Thiazide-induced adverse metabolic effects in hypertensive patients; CRC cis rs7617773 0.780 rs11720026 chr3:48377921 T/C cg11946769 chr3:48343235 NME6 0.74 9.91 0.48 2.03e-20 Coronary artery disease; CRC cis rs7587476 0.906 rs2070096 chr2:215645545 C/G cg04004882 chr2:215674386 BARD1 0.61 7.49 0.38 6.45e-13 Neuroblastoma; CRC cis rs4664293 0.625 rs6432543 chr2:160495331 C/A cg08347373 chr2:160653686 CD302 0.39 6.68 0.35 1.03e-10 Monocyte percentage of white cells; CRC cis rs6969780 1.000 rs6976129 chr7:27177746 C/T cg26364809 chr7:27145159 NA -0.73 -6.82 -0.35 4.39e-11 Diastolic blood pressure;Blood pressure traits (multi-trait analysis);Systolic blood pressure;Hypertension; CRC cis rs7255436 0.830 rs4350678 chr19:8447366 A/G cg10174797 chr19:8464628 RAB11B 0.44 7.65 0.39 2.27e-13 HDL cholesterol; CRC trans rs7868992 0.515 rs902496 chr9:116989776 G/T cg10545682 chr1:151512625 TUFT1 0.53 6.09 0.32 3.08e-9 Tourette syndrome; CRC cis rs6121246 0.909 rs6119720 chr20:30347568 T/G cg13852791 chr20:30311386 BCL2L1 0.69 10.77 0.51 2.2e-23 Mean corpuscular hemoglobin; CRC cis rs763121 0.853 rs5757253 chr22:39104320 C/T cg06544989 chr22:39130855 UNC84B 0.48 7.68 0.39 1.9e-13 Menopause (age at onset); CRC cis rs4713118 0.824 rs742046 chr6:27739254 A/G cg26587870 chr6:27730563 NA -0.48 -7.15 -0.37 5.58e-12 Parkinson's disease; CRC cis rs9462027 0.506 rs6934662 chr6:34759884 G/C cg07306190 chr6:34760872 UHRF1BP1 -0.35 -6.31 -0.33 9.13e-10 Systemic lupus erythematosus; CRC cis rs10492096 0.853 rs7300092 chr12:6607364 T/C cg07142400 chr12:6602447 NCAPD2;MRPL51 -0.46 -5.61 -0.3 4.34e-8 Hip geometry; CRC trans rs61931739 0.500 rs10844789 chr12:34202279 C/G cg26384229 chr12:38710491 ALG10B 0.54 6.87 0.35 3.22e-11 Morning vs. evening chronotype; CRC trans rs1499614 1.000 rs1267817 chr7:66110040 G/T cg10756647 chr7:56101905 PSPH 0.75 7.81 0.4 7.97e-14 Gout; CRC cis rs72781680 0.898 rs10490751 chr2:24001356 A/G cg08917208 chr2:24149416 ATAD2B 0.86 8.35 0.42 1.86e-15 Lymphocyte counts; CRC cis rs344364 0.602 rs2437745 chr16:1908431 G/C cg03013636 chr16:1946785 NA -0.38 -5.64 -0.3 3.74e-8 Glomerular filtration rate in chronic kidney disease; CRC cis rs2739330 0.734 rs2000467 chr22:24241533 C/T cg18538332 chr22:24372958 LOC391322 0.66 9.68 0.47 1.16e-19 Liver enzyme levels (gamma-glutamyl transferase); CRC trans rs17133277 0.702 rs56175518 chr7:3493365 A/G cg25123566 chr12:47610734 FAM113B;LOC100233209 -0.51 -5.97 -0.31 6.21e-9 Facial morphology (factor 5, width of mouth relative to central midface); CRC cis rs7945705 0.902 rs10743093 chr11:8869129 A/G cg00186954 chr11:8933980 ST5;C11orf17 0.44 6.72 0.35 8.18e-11 Hemoglobin concentration; CRC cis rs12580194 0.593 rs7485979 chr12:55789043 A/T cg23425280 chr12:56401806 NA -0.46 -5.71 -0.3 2.49e-8 Cancer; CRC cis rs41271473 0.687 rs7535661 chr1:228887667 C/T cg00850481 chr1:228891306 NA -0.42 -6.43 -0.33 4.4e-10 Chronic lymphocytic leukemia; CRC cis rs10927875 0.619 rs7546589 chr1:16129530 A/G cg21385522 chr1:16154831 NA -0.66 -10.17 -0.49 2.69e-21 Dilated cardiomyopathy; CRC trans rs11026407 0.967 rs7127246 chr11:22060228 C/G cg02570644 chr16:68123248 NFATC3 -0.51 -6.24 -0.33 1.36e-9 Plasma thyroid-stimulating hormone levels; CRC cis rs4713118 0.629 rs203887 chr6:28021269 C/T cg15845792 chr6:28175446 NA 0.83 10.65 0.51 5.91e-23 Parkinson's disease; CRC cis rs7017697 1.000 rs2410612 chr8:19681647 A/G cg03894339 chr8:19674705 INTS10 0.41 5.61 0.3 4.35e-8 Breast cancer; CRC cis rs2033711 0.870 rs4801270 chr19:58932762 C/A cg00825309 chr19:58991885 ZNF446 -0.46 -6.71 -0.35 8.75e-11 Uric acid clearance; CRC cis rs7215564 0.908 rs2340770 chr17:78754770 T/C cg09596252 chr17:78655493 RPTOR -0.58 -6.1 -0.32 3.01e-9 Myopia (pathological); CRC cis rs6499255 0.904 rs60010276 chr16:69674805 C/T cg15192750 chr16:69999425 NA 0.56 7.54 0.38 4.63e-13 IgE levels; CRC cis rs4689388 0.890 rs4689398 chr4:6302199 C/T cg00701064 chr4:6280414 WFS1 0.79 14.04 0.61 2.04e-35 Type 2 diabetes and other traits;Type 2 diabetes; CRC cis rs73206853 0.841 rs73191818 chr12:110918721 T/G cg12870014 chr12:110450643 ANKRD13A 0.75 8.02 0.4 1.88e-14 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg06416885 chr4:100009900 ADH5 0.49 6.91 0.36 2.59e-11 Anxiety disorder; CRC cis rs10089 1.000 rs1842006 chr5:127508687 G/A cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.7 9.53 0.46 3.72e-19 Ileal carcinoids; CRC cis rs7618915 0.532 rs13060675 chr3:52674300 T/G cg11645453 chr3:52864694 ITIH4 0.36 6.25 0.33 1.29e-9 Bipolar disorder; CRC cis rs875971 0.830 rs6967708 chr7:65657313 A/T cg00343986 chr7:65444356 GUSB -0.42 -5.98 -0.31 5.8e-9 Aortic root size; CRC cis rs7617773 0.539 rs13087050 chr3:48392800 C/T cg11946769 chr3:48343235 NME6 0.58 7.93 0.4 3.35e-14 Coronary artery disease; CRC cis rs11252926 0.598 rs4881256 chr10:453831 T/A cg16386425 chr10:429943 DIP2C -0.45 -6.96 -0.36 1.88e-11 Psychosis in Alzheimer's disease; CRC cis rs7605827 0.930 rs7577436 chr2:15528281 C/T cg19274914 chr2:15703543 NA 0.39 5.9 0.31 9.03e-9 Educational attainment (years of education); CRC cis rs4253772 0.591 rs7291444 chr22:46656246 T/G cg09491104 chr22:46646882 C22orf40 -0.46 -6.76 -0.35 6.33e-11 LDL cholesterol;Cholesterol, total; CRC cis rs1046896 0.538 rs3803771 chr17:80687758 G/A cg02398342 chr17:80708632 TBCD;FN3K -0.53 -9.59 -0.47 2.33e-19 Glycated hemoglobin levels; CRC cis rs863345 0.967 rs10908681 chr1:158522712 C/T cg12129480 chr1:158549410 OR10X1 -0.26 -5.68 -0.3 2.93e-8 Pneumococcal bacteremia; CRC cis rs4900538 0.855 rs72698602 chr14:102880454 T/C cg18135206 chr14:102964638 TECPR2 -0.96 -17.41 -0.69 1.42e-48 Mean corpuscular volume;Mean corpuscular hemoglobin; CRC cis rs9818758 0.607 rs56004653 chr3:49072228 T/C cg01304814 chr3:48885189 PRKAR2A 0.86 6.24 0.33 1.32e-9 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; CRC cis rs6120849 0.754 rs6120828 chr20:33674460 A/G cg24642439 chr20:33292090 TP53INP2 0.41 5.61 0.3 4.22e-8 Protein C levels; CRC cis rs9287719 0.649 rs12476554 chr2:10727747 A/G cg00105475 chr2:10696890 NA 0.46 7.17 0.37 4.93e-12 Prostate cancer; CRC cis rs2370759 1.000 rs11008865 chr10:32574842 C/T cg01819863 chr10:32635814 EPC1 1.07 12.57 0.57 7.19e-30 Sexual dysfunction (female); CRC cis rs728616 0.702 rs78734698 chr10:81756449 G/A cg05935833 chr10:81318306 SFTPA2 -0.77 -8.15 -0.41 7.96e-15 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs12681287 0.547 rs35871312 chr8:87543219 T/C cg27223183 chr8:87520930 FAM82B 0.5 6.72 0.35 7.91e-11 Caudate activity during reward; CRC cis rs2075371 0.796 rs1978504 chr7:134006933 C/T cg11752832 chr7:134001865 SLC35B4 -0.43 -6.55 -0.34 2.24e-10 Mean platelet volume; CRC cis rs10504229 0.683 rs16921810 chr8:58106067 A/G cg24829409 chr8:58192753 C8orf71 -0.56 -8.01 -0.4 2.05e-14 Developmental language disorder (linguistic errors); CRC cis rs9322817 1.000 rs6942231 chr6:105191814 C/T cg02098413 chr6:105308735 HACE1 -0.35 -6.5 -0.34 3.05e-10 Thyroid stimulating hormone; CRC cis rs7429990 0.932 rs12493348 chr3:48143538 A/T cg11946769 chr3:48343235 NME6 -0.44 -5.88 -0.31 1.02e-8 Educational attainment (years of education); CRC cis rs10504229 0.775 rs17804840 chr8:58157045 C/T cg02725872 chr8:58115012 NA -0.59 -9.18 -0.45 4.97e-18 Developmental language disorder (linguistic errors); CRC trans rs1933755 0.614 rs6569692 chr6:130924488 T/A cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 0.79 6.0 0.31 5.35e-9 Colorectal cancer (calcium intake interaction); CRC cis rs6502050 0.835 rs67106357 chr17:80116826 T/G cg25804541 chr17:80189381 SLC16A3 -0.3 -5.88 -0.31 9.83e-9 Life satisfaction; CRC cis rs4665809 0.556 rs6730311 chr2:26419474 C/T cg26119090 chr2:26468346 HADHA;HADHB -0.99 -13.9 -0.61 6.86e-35 Gut microbiome composition (summer); CRC trans rs208515 0.560 rs207084 chr6:66776966 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.13 -22.19 -0.77 2.39e-67 Exhaled nitric oxide levels; CRC cis rs629535 0.734 rs542288 chr8:70057149 G/T cg26132723 chr8:70041827 NA -0.36 -5.92 -0.31 8.01e-9 Dupuytren's disease; CRC cis rs9925964 0.591 rs11649653 chr16:30918487 C/G cg03418659 chr16:31128414 MYST1 0.44 6.5 0.34 3.05e-10 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs12826942 0.605 rs17801478 chr12:42481545 A/G cg11827402 chr12:42719852 PPHLN1;ZCRB1 0.62 6.99 0.36 1.5e-11 Coronary artery disease; CRC cis rs753955 0.592 rs1324972 chr13:24348159 C/T cg25267304 chr13:24462978 PCOTH;MIPEP 0.4 5.61 0.3 4.3e-8 Lung cancer; CRC cis rs1129187 0.755 rs2274514 chr6:42934500 C/T cg02353165 chr6:42928485 GNMT 0.71 12.11 0.56 3.71e-28 Alzheimer's disease in APOE e4+ carriers; CRC cis rs2645694 0.626 rs12502590 chr4:77823642 G/A cg03477792 chr4:77819574 ANKRD56 0.46 6.71 0.35 8.61e-11 Emphysema distribution in smoking; CRC cis rs4332037 0.539 rs1533827 chr7:2074290 A/G cg21155852 chr7:2048760 MAD1L1 0.47 6.42 0.33 4.78e-10 Bipolar disorder; CRC cis rs9916302 0.706 rs2338799 chr17:37513941 G/A cg15445000 chr17:37608096 MED1 -0.35 -6.12 -0.32 2.59e-9 Glomerular filtration rate (creatinine); CRC cis rs7474896 0.583 rs12776092 chr10:38015795 G/C cg25427524 chr10:38739819 LOC399744 -0.61 -7.69 -0.39 1.72e-13 Obesity (extreme); CRC cis rs9311474 0.569 rs7614981 chr3:52566914 G/T cg17372223 chr3:52568218 NT5DC2 0.41 6.45 0.34 4e-10 Electroencephalogram traits; CRC trans rs35110281 0.748 rs4997353 chr21:45002329 A/C cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.43 6.94 0.36 2.07e-11 Mean corpuscular volume; CRC cis rs6541297 1.000 rs11122405 chr1:230282997 C/A cg05784532 chr1:230284198 GALNT2 0.43 5.91 0.31 8.48e-9 Coronary artery disease; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg06588201 chr4:174430487 NA 0.22 6.19 0.32 1.8e-9 Liver disease severity in Alagille syndrome; CRC cis rs17270561 0.636 rs10946793 chr6:25699999 A/G cg16482183 chr6:26056742 HIST1H1C 0.72 8.72 0.43 1.37e-16 Iron status biomarkers; CRC trans rs6601327 0.607 rs35316422 chr8:9575129 G/T cg06636001 chr8:8085503 FLJ10661 -0.54 -7.84 -0.4 6.46e-14 Multiple myeloma (hyperdiploidy); CRC cis rs10504229 0.953 rs59265461 chr8:58189701 A/T cg01721255 chr8:58191610 C8orf71 0.49 6.17 0.32 2e-9 Developmental language disorder (linguistic errors); CRC cis rs3892630 0.824 rs34748593 chr19:33240447 T/C cg22980127 chr19:33182716 NUDT19 0.92 11.22 0.53 6.11e-25 Red blood cell traits; CRC cis rs7945705 0.935 rs11042102 chr11:8882164 C/T cg12365402 chr11:9010492 NRIP3 0.46 7.32 0.37 1.94e-12 Hemoglobin concentration; CRC trans rs7314326 0.771 rs10771049 chr12:24121630 A/G cg12543219 chr10:135016451 KNDC1 0.29 6.03 0.32 4.34e-9 Schizophrenia; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg14901232 chr18:74208357 NA 0.36 6.01 0.31 4.84e-9 Liver disease severity in Alagille syndrome; CRC cis rs1524976 1.000 rs4688570 chr3:65466168 G/C cg16238336 chr3:65465873 MAGI1 0.49 7.2 0.37 4.23e-12 PR interval; CRC cis rs11123170 0.542 rs11123169 chr2:113967075 C/T cg21550016 chr2:113992930 PAX8;LOC440839;LOC654433 -0.48 -6.54 -0.34 2.31e-10 Renal function-related traits (BUN); CRC trans rs1005277 0.603 rs1998062 chr10:38457652 G/C cg23533926 chr12:111358616 MYL2 -0.5 -7.56 -0.38 4.1e-13 Extrinsic epigenetic age acceleration; CRC cis rs875971 0.825 rs1129531 chr7:65619104 C/T cg00343986 chr7:65444356 GUSB -0.43 -6.08 -0.32 3.3e-9 Aortic root size; CRC cis rs1799949 1.000 rs11656097 chr17:41290613 G/T cg23758822 chr17:41437982 NA 0.79 13.45 0.6 3.6e-33 Menopause (age at onset); CRC cis rs7020830 0.830 rs12554976 chr9:37244505 G/T cg14294708 chr9:37120828 ZCCHC7 1.13 22.78 0.78 1.32e-69 Schizophrenia; CRC cis rs1953600 0.870 rs2236557 chr10:81923961 A/G cg00277334 chr10:82204260 NA 0.37 5.83 0.31 1.31e-8 Sarcoidosis; CRC cis rs61774743 0.521 rs60144015 chr1:41845246 C/A cg08462924 chr1:41848221 NA 0.44 6.88 0.35 3.12e-11 Intelligence (multi-trait analysis); CRC cis rs875971 0.825 rs28480509 chr7:66099224 A/G cg11764359 chr7:65958608 NA -0.59 -8.83 -0.44 6.21e-17 Aortic root size; CRC cis rs7618501 0.633 rs9853222 chr3:50022926 T/C cg24110177 chr3:50126178 RBM5 -0.46 -6.91 -0.36 2.46e-11 Intelligence (multi-trait analysis); CRC cis rs10504229 0.683 rs58438731 chr8:58134790 C/T cg22535103 chr8:58192502 C8orf71 -0.7 -9.34 -0.46 1.47e-18 Developmental language disorder (linguistic errors); CRC cis rs7605827 0.930 rs10200346 chr2:15635728 A/C cg19274914 chr2:15703543 NA 0.39 6.0 0.31 5.1e-9 Educational attainment (years of education); CRC cis rs12908161 0.959 rs2175567 chr15:85200946 C/G cg11189052 chr15:85197271 WDR73 0.63 8.96 0.44 2.47e-17 Schizophrenia; CRC cis rs753778 0.559 rs2288997 chr8:142200731 A/G cg23750338 chr8:142222470 SLC45A4 -0.42 -5.79 -0.3 1.62e-8 Reticulocyte fraction of red cells;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; CRC trans rs1997103 1.000 rs9642580 chr7:55400359 G/A cg20935933 chr6:143382018 AIG1 0.52 6.73 0.35 7.38e-11 QRS interval (sulfonylurea treatment interaction); CRC cis rs13108904 0.901 rs7673398 chr4:1300077 G/A cg20092199 chr4:1342459 KIAA1530 0.41 7.61 0.39 2.85e-13 Obesity-related traits; CRC cis rs3768617 1.000 rs1360704 chr1:183099380 C/T ch.1.3577855R chr1:183094577 LAMC1 -0.61 -9.12 -0.45 7.69e-18 Fuchs's corneal dystrophy; CRC cis rs4253772 0.591 rs6008365 chr22:46652929 G/A cg03482458 chr22:46692211 CN5H6.4;GTSE1 0.48 6.42 0.33 4.72e-10 LDL cholesterol;Cholesterol, total; CRC cis rs6694672 1.000 rs1576877 chr1:197047639 A/G cg13682187 chr1:196946512 CFHR5 0.55 8.15 0.41 7.57e-15 Asthma; CRC cis rs7703744 0.681 rs73239278 chr5:118695051 G/A cg02283238 chr5:118691126 TNFAIP8 0.47 6.41 0.33 4.98e-10 Lobe attachment (rater-scored or self-reported); CRC cis rs34779708 0.801 rs12098720 chr10:35538683 G/A cg03585969 chr10:35415529 CREM 0.58 7.35 0.38 1.56e-12 Inflammatory bowel disease;Crohn's disease; CRC cis rs10752881 0.935 rs3935221 chr1:182969010 A/G ch.1.3577855R chr1:183094577 LAMC1 0.86 15.01 0.64 3.66e-39 Colorectal cancer; CRC cis rs875971 0.638 rs10278816 chr7:66036987 T/C cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.43 -6.31 -0.33 9.14e-10 Aortic root size; CRC cis rs245880 0.740 rs245887 chr7:29190408 G/A cg17163760 chr7:29186267 CPVL -0.39 -6.73 -0.35 7.63e-11 Warfarin maintenance dose; CRC cis rs12762955 0.561 rs2620942 chr10:1048398 C/T cg20503657 chr10:835505 NA 0.45 6.26 0.33 1.21e-9 Response to angiotensin II receptor blocker therapy; CRC cis rs2836950 0.762 rs8134638 chr21:40644170 T/C cg11890956 chr21:40555474 PSMG1 -0.5 -6.57 -0.34 1.94e-10 Menarche (age at onset); CRC cis rs7618501 0.602 rs2245365 chr3:50097319 C/A cg05623727 chr3:50126028 RBM5 -0.46 -7.62 -0.39 2.67e-13 Intelligence (multi-trait analysis); CRC cis rs7618915 0.547 rs13069481 chr3:52666866 C/T cg08222913 chr3:52553049 STAB1 -0.34 -6.21 -0.32 1.63e-9 Bipolar disorder; CRC cis rs4722166 0.695 rs7793125 chr7:22809160 A/G cg26061582 chr7:22766209 IL6 0.52 8.23 0.41 4.41e-15 Lung cancer; CRC cis rs394563 0.690 rs237009 chr6:149759552 C/T cg07561610 chr6:149771807 ZC3H12D -0.31 -5.72 -0.3 2.34e-8 Dupuytren's disease; CRC cis rs13108904 0.901 rs4493484 chr4:1279944 G/A cg16405210 chr4:1374714 KIAA1530 -0.44 -5.94 -0.31 7.23e-9 Obesity-related traits; CRC trans rs7395662 0.963 rs4882170 chr11:48724214 C/T cg21153622 chr11:89784906 NA -0.48 -7.72 -0.39 1.45e-13 HDL cholesterol; CRC trans rs61931739 0.500 rs7306053 chr12:34510848 T/G cg26384229 chr12:38710491 ALG10B 0.62 9.17 0.45 5.2e-18 Morning vs. evening chronotype; CRC cis rs877282 0.786 rs11253392 chr10:788768 G/A cg17470449 chr10:769945 NA 0.69 9.03 0.45 1.51e-17 Uric acid levels; CRC cis rs11229555 0.609 rs4519113 chr11:58216825 T/C cg15696309 chr11:58395628 NA -0.83 -10.55 -0.5 1.33e-22 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; CRC cis rs9787249 0.957 rs6670841 chr1:40220284 C/G cg01941586 chr1:40203715 PPIE -0.43 -5.9 -0.31 8.94e-9 Blood protein levels; CRC cis rs7086803 1.000 rs7075671 chr10:114501685 A/G cg03281572 chr10:114502318 VTI1A 0.75 6.34 0.33 7.77e-10 Lung cancer; CRC trans rs1997103 0.954 rs7811098 chr7:55413012 A/G cg20935933 chr6:143382018 AIG1 0.5 6.46 0.34 3.66e-10 QRS interval (sulfonylurea treatment interaction); CRC cis rs12368653 0.544 rs11172304 chr12:58097862 T/C cg15848620 chr12:58087721 OS9 -0.44 -6.17 -0.32 1.97e-9 Multiple sclerosis; CRC cis rs2992756 1.000 rs2992756 chr1:18807339 T/C cg14356550 chr1:18808102 KLHDC7A -0.46 -7.2 -0.37 4.21e-12 Breast cancer; CRC cis rs7552404 0.924 rs7550974 chr1:76204185 A/G cg10523679 chr1:76189770 ACADM 0.93 14.16 0.62 7.07e-36 Blood metabolite levels;Acylcarnitine levels; CRC cis rs1552244 0.572 rs17032426 chr3:10167112 G/A cg08888203 chr3:10149979 C3orf24 0.71 8.57 0.43 4.18e-16 Alzheimer's disease; CRC cis rs7786808 0.544 rs6971888 chr7:158193835 G/A cg09998033 chr7:158218633 PTPRN2 0.54 7.75 0.39 1.18e-13 Obesity-related traits; CRC cis rs7618915 0.531 rs77146033 chr3:52701501 G/T cg10802521 chr3:52805072 NEK4 -0.58 -8.88 -0.44 4.3e-17 Bipolar disorder; CRC cis rs9322193 0.923 rs9478291 chr6:150050570 A/G cg07701084 chr6:150067640 NUP43 0.6 8.95 0.44 2.68e-17 Lung cancer; CRC cis rs9807989 0.839 rs10182710 chr2:102981306 A/G cg03938978 chr2:103052716 IL18RAP 0.37 6.1 0.32 3.01e-9 Asthma; CRC cis rs1552244 1.000 rs33917318 chr3:10067797 T/C cg10729496 chr3:10149963 C3orf24 0.5 6.64 0.34 1.28e-10 Alzheimer's disease; CRC cis rs7727544 0.716 rs72793278 chr5:131561372 C/A cg09877947 chr5:131593287 PDLIM4 0.35 6.41 0.33 5.14e-10 Blood metabolite levels; CRC cis rs11123610 0.679 rs34705357 chr2:3716032 C/T cg19052272 chr2:3704530 ALLC -0.47 -6.04 -0.32 4.11e-9 Response to inhaled corticosteroid treatment in asthma (change in FEV1); CRC cis rs3617 0.625 rs2245647 chr3:52862753 A/G cg15147215 chr3:52552868 STAB1 -0.54 -9.36 -0.46 1.28e-18 Red blood cell count;Autism spectrum disorder or schizophrenia; CRC cis rs736408 0.609 rs13061423 chr3:52790213 T/C cg10802521 chr3:52805072 NEK4 -0.59 -8.98 -0.44 2.08e-17 Bipolar disorder; CRC cis rs35146811 0.586 rs6946168 chr7:99598286 C/T cg03265037 chr7:99691720 MIR25;MCM7;MIR106B;MIR93 0.44 5.95 0.31 6.69e-9 Coronary artery disease; CRC cis rs7309 0.935 rs1921309 chr2:162048975 T/A cg13854012 chr2:162103682 NA -0.47 -7.61 -0.39 3.01e-13 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Educational attainment; CRC cis rs2404602 0.692 rs12911902 chr15:77053575 T/C cg23625390 chr15:77176239 SCAPER 0.48 6.83 0.35 4.16e-11 Blood metabolite levels; CRC cis rs7615952 0.599 rs12485717 chr3:125707075 C/T cg02772935 chr3:125709198 NA 0.48 5.63 0.3 3.86e-8 Blood pressure (smoking interaction); CRC cis rs7949030 0.626 rs61296092 chr11:62320838 T/C cg22862634 chr11:62369728 EML3;MTA2 0.58 10.37 0.5 5.43e-22 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; CRC cis rs17376456 0.825 rs10054790 chr5:93272520 A/G cg09848695 chr5:92956644 FAM172A;MIR2277 0.7 5.99 0.31 5.39e-9 Diabetic retinopathy; CRC cis rs6089584 0.888 rs2181590 chr20:60622843 T/C cg23463467 chr20:60627584 TAF4 0.34 5.92 0.31 8.12e-9 Body mass index; CRC cis rs9326248 0.520 rs74830 chr11:117090558 C/T cg26566898 chr11:117069891 TAGLN -0.31 -6.55 -0.34 2.2e-10 Blood protein levels; CRC trans rs10435719 0.899 rs11250177 chr8:11799099 G/A cg08975724 chr8:8085496 FLJ10661 0.41 6.11 0.32 2.85e-9 C-reactive protein levels or triglyceride levels (pleiotropy); CRC trans rs66573146 0.803 rs59742225 chr4:6969942 C/T cg07817883 chr1:32538562 TMEM39B 1.53 13.61 0.6 8.65e-34 Granulocyte percentage of myeloid white cells; CRC cis rs7725052 0.609 rs10941509 chr5:40462358 A/G cg09067459 chr5:40385259 NA -0.46 -7.58 -0.39 3.61e-13 Pediatric autoimmune diseases; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg25490411 chr4:103681941 MANBA 0.5 7.13 0.37 6.53e-12 Response to antipsychotic treatment; CRC cis rs240764 0.578 rs9498252 chr6:101194481 A/G cg09795085 chr6:101329169 ASCC3 0.41 5.69 0.3 2.8e-8 Neuroticism; CRC cis rs3008870 0.792 rs72673729 chr1:67441673 T/TG cg08660285 chr1:67390436 MIER1;WDR78 -1.04 -14.74 -0.63 4.01e-38 Lymphocyte percentage of white cells; CRC trans rs61931739 0.500 rs7311302 chr12:34557211 T/C cg13010199 chr12:38710504 ALG10B 0.46 6.57 0.34 2.02e-10 Morning vs. evening chronotype; CRC cis rs8060686 0.641 rs73598006 chr16:68074454 C/G cg26727032 chr16:67993705 SLC12A4 -0.6 -8.03 -0.4 1.76e-14 HDL cholesterol;Metabolic syndrome; CRC cis rs7412746 0.611 rs66847267 chr1:150875173 C/A cg15448220 chr1:150897856 SETDB1 0.46 6.78 0.35 5.42e-11 Melanoma; CRC cis rs950169 0.919 rs17300292 chr15:84762568 G/C cg24253500 chr15:84953950 NA 0.38 6.49 0.34 3.23e-10 Schizophrenia; CRC cis rs3617 0.539 rs12629687 chr3:52950659 T/C cg11645453 chr3:52864694 ITIH4 -0.36 -6.78 -0.35 5.57e-11 Red blood cell count;Autism spectrum disorder or schizophrenia; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg08932106 chr10:23003259 PIP4K2A 0.47 6.52 0.34 2.6e-10 Response to antipsychotic treatment; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg19418924 chr11:2951659 PHLDA2 0.41 6.05 0.32 3.93e-9 Intelligence (multi-trait analysis); CRC cis rs10504229 1.000 rs60454728 chr8:58173781 G/A cg22535103 chr8:58192502 C8orf71 -0.82 -12.27 -0.56 9.63e-29 Developmental language disorder (linguistic errors); CRC cis rs4727027 0.901 rs66800495 chr7:148763702 T/C cg12479418 chr7:148823350 ZNF425;ZNF398 0.46 6.25 0.33 1.24e-9 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC cis rs6484504 0.576 rs169623 chr11:31184157 T/C cg14844989 chr11:31128820 NA -0.34 -5.93 -0.31 7.83e-9 Red blood cell count; CRC cis rs10870270 0.956 rs4880405 chr10:133787021 G/A cg17892150 chr10:133769511 PPP2R2D -0.76 -11.26 -0.53 4.29e-25 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; CRC cis rs28386778 0.897 rs9915552 chr17:61869095 G/A cg11494091 chr17:61959527 GH2 0.62 10.57 0.5 1.09e-22 Prudent dietary pattern; CRC cis rs904251 0.523 rs9369005 chr6:37483109 A/G cg01843034 chr6:37503916 NA -0.39 -7.19 -0.37 4.31e-12 Cognitive performance; CRC cis rs7772486 0.846 rs2748499 chr6:146315002 T/C cg23711669 chr6:146136114 FBXO30 0.67 11.32 0.53 2.69e-25 Lobe attachment (rater-scored or self-reported); CRC cis rs2180341 0.843 rs4895821 chr6:127572761 T/A cg27446573 chr6:127587934 RNF146 0.98 14.61 0.63 1.29e-37 Breast cancer; CRC cis rs4481887 0.893 rs1339990 chr1:248509495 C/T cg00666640 chr1:248458726 OR2T12 -0.49 -9.0 -0.44 1.87e-17 Common traits (Other); CRC cis rs6714710 0.603 rs1470483 chr2:98393894 C/T cg26665480 chr2:98280029 ACTR1B 0.54 7.25 0.37 2.97e-12 Posterior cortical atrophy and Alzheimer's disease; CRC cis rs453301 0.682 rs2929451 chr8:9085295 A/T cg08975724 chr8:8085496 FLJ10661 0.37 5.68 0.3 2.96e-8 Joint mobility (Beighton score); CRC cis rs728616 0.867 rs12414096 chr10:81713629 A/G cg05935833 chr10:81318306 SFTPA2 -0.75 -8.24 -0.41 4.17e-15 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs2361718 0.967 rs12942941 chr17:78103013 C/T cg27427491 chr17:78079615 GAA -0.36 -5.81 -0.3 1.51e-8 Yeast infection; CRC cis rs9926296 0.744 rs164747 chr16:89708680 T/G cg03605463 chr16:89740564 NA 0.58 8.92 0.44 3.42e-17 Vitiligo; CRC cis rs6951245 0.554 rs10270249 chr7:1151886 G/T cg18402987 chr7:1209562 NA 0.55 6.73 0.35 7.66e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs7647973 0.580 rs11716334 chr3:49230096 G/A cg06212747 chr3:49208901 KLHDC8B 0.38 5.8 0.3 1.52e-8 Menarche (age at onset); CRC cis rs7615952 0.641 rs4490307 chr3:125712676 T/G cg06494592 chr3:125709126 NA -0.53 -6.78 -0.35 5.74e-11 Blood pressure (smoking interaction); CRC cis rs9322193 0.962 rs4552 chr6:150132319 A/T cg00933542 chr6:150070202 PCMT1 0.28 5.64 0.3 3.66e-8 Lung cancer; CRC cis rs7923452 0.507 rs215494 chr10:30776589 T/G cg25182066 chr10:30743637 MAP3K8 -0.54 -7.27 -0.37 2.71e-12 Itch intensity from mosquito bite; CRC trans rs2228479 0.867 rs62052189 chr16:89975555 G/C cg21302420 chr1:112162376 RAP1A 0.65 6.41 0.33 5.02e-10 Skin colour saturation; CRC cis rs77861329 1.000 rs55664415 chr3:52124885 G/A cg08692210 chr3:52188851 WDR51A 0.83 6.97 0.36 1.69e-11 Macrophage inflammatory protein 1b levels; CRC trans rs1005277 0.540 rs116205409 chr10:38478970 G/A cg23533926 chr12:111358616 MYL2 -0.54 -8.21 -0.41 5e-15 Extrinsic epigenetic age acceleration; CRC cis rs1046896 0.586 rs9897951 chr17:80810662 T/C cg03160526 chr17:80928410 B3GNTL1 0.6 8.21 0.41 5.08e-15 Glycated hemoglobin levels; CRC cis rs6500602 0.626 rs7665 chr16:4562512 A/G cg08645402 chr16:4508243 NA 0.58 8.45 0.42 9.47e-16 Schizophrenia; CRC cis rs6684514 1.000 rs6679145 chr1:156256000 T/C cg16558208 chr1:156270281 VHLL 0.58 9.04 0.45 1.34e-17 Mean corpuscular hemoglobin concentration;Glycated hemoglobin levels; CRC cis rs9457247 1.000 rs932644 chr6:167404187 A/C cg23791538 chr6:167370224 RNASET2 -0.38 -5.94 -0.31 7.32e-9 Crohn's disease; CRC cis rs10242455 0.702 rs28377312 chr7:98984213 G/A cg18809830 chr7:99032528 PTCD1 -1.28 -8.7 -0.43 1.57e-16 Blood metabolite levels; CRC cis rs1873147 1.000 rs12440411 chr15:63313581 T/G cg12160578 chr15:63334699 TPM1 -0.4 -5.73 -0.3 2.28e-8 Orofacial clefts; CRC cis rs55665837 1.000 rs34382046 chr11:14451318 C/T cg19336497 chr11:14380999 RRAS2 -0.39 -6.64 -0.34 1.3100000000000001e-10 Vitamin D levels; CRC cis rs1552244 1.000 rs6764168 chr3:10123805 A/G cg00166722 chr3:10149974 C3orf24 0.71 9.55 0.47 3.15e-19 Alzheimer's disease; CRC trans rs7819412 0.540 rs2409726 chr8:11043138 T/C cg16141378 chr3:129829833 LOC729375 0.42 6.15 0.32 2.28e-9 Triglycerides; CRC trans rs12599106 0.629 rs1391904 chr16:34548934 C/T cg18110333 chr6:292329 DUSP22 -0.58 -8.47 -0.42 8.16e-16 Menopause (age at onset); CRC cis rs921968 0.565 rs2037622 chr2:219609440 T/C cg02176678 chr2:219576539 TTLL4 -0.39 -6.23 -0.32 1.4e-9 Mean corpuscular hemoglobin concentration; CRC cis rs2179367 0.959 rs4897125 chr6:149766208 G/A cg07828024 chr6:149772892 ZC3H12D -0.38 -6.37 -0.33 6.42e-10 Dupuytren's disease; CRC cis rs6502050 0.835 rs6502070 chr17:80112634 G/A cg09264619 chr17:80180166 NA -0.34 -5.7 -0.3 2.67e-8 Life satisfaction; CRC cis rs7811142 1.000 rs68116612 chr7:100006493 G/A cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.15 17.77 0.7 5.37e-50 Platelet count; CRC cis rs2204008 0.545 rs1663283 chr12:38132039 G/A cg26384229 chr12:38710491 ALG10B -0.55 -8.2 -0.41 5.3e-15 Bladder cancer; CRC cis rs1322512 0.677 rs2695255 chr6:152926004 G/A cg03415253 chr6:152958462 SYNE1 -0.39 -6.14 -0.32 2.44e-9 Tonometry; CRC cis rs7727544 0.548 rs4705938 chr5:131694077 A/G cg11843238 chr5:131593191 PDLIM4 0.36 6.53 0.34 2.43e-10 Blood metabolite levels; CRC cis rs11628318 0.614 rs1190337 chr14:103106159 A/C cg08075719 chr14:103021372 NA -0.67 -7.73 -0.39 1.3e-13 Platelet count; CRC cis rs501120 0.584 rs673778 chr10:44733739 G/T cg09554077 chr10:44749378 NA 0.64 7.06 0.36 9.84e-12 Coronary artery disease;Coronary heart disease; CRC cis rs2153535 0.584 rs9502723 chr6:8541504 G/A cg21535247 chr6:8435926 SLC35B3 0.5 7.72 0.39 1.45e-13 Motion sickness; CRC cis rs8005677 1.000 rs1956880 chr14:23394007 A/G cg01529538 chr14:23388837 RBM23 0.39 5.99 0.31 5.49e-9 Cognitive ability (multi-trait analysis); CRC cis rs7727544 0.716 rs4705926 chr5:131561758 C/T cg12564285 chr5:131593104 PDLIM4 0.38 7.14 0.37 6.06e-12 Blood metabolite levels; CRC cis rs7618915 0.547 rs34215106 chr3:52659124 T/C cg15147215 chr3:52552868 STAB1 -0.62 -10.22 -0.49 1.76e-21 Bipolar disorder; CRC cis rs4908768 0.501 rs1473420 chr1:8616838 T/G cg20416874 chr1:8611966 RERE -0.46 -6.53 -0.34 2.49e-10 Neuroticism (multi-trait analysis);Subjective well-being (multi-trait analysis); CRC cis rs7208859 0.673 rs61348930 chr17:29221763 C/T cg13385521 chr17:29058706 SUZ12P 0.69 7.93 0.4 3.48e-14 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs2836974 0.644 rs719230 chr21:40676307 C/T cg22974920 chr21:40686053 BRWD1 -0.45 -6.21 -0.32 1.56e-9 Cognitive function; CRC cis rs7264396 0.573 rs55969606 chr20:34075688 T/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.39 -6.51 -0.34 2.73e-10 Total cholesterol levels; CRC cis rs9910055 0.762 rs2240226 chr17:42266218 C/T cg16434002 chr17:42200994 HDAC5 -0.46 -6.19 -0.32 1.79e-9 Total body bone mineral density; CRC cis rs72615157 0.561 rs113401658 chr7:99858505 C/T cg13153964 chr7:100026424 MEPCE;ZCWPW1 0.82 9.42 0.46 8.42e-19 Lung function (FEV1/FVC); CRC cis rs1023500 0.505 rs134889 chr22:42674350 A/T cg04733989 chr22:42467013 NAGA 0.42 6.09 0.32 3.17e-9 Schizophrenia; CRC cis rs2404602 0.692 rs72738889 chr15:76992063 G/A cg03037974 chr15:76606532 NA 0.69 12.13 0.56 3.19e-28 Blood metabolite levels; CRC cis rs2921036 0.545 rs4840975 chr8:8363258 C/T cg06636001 chr8:8085503 FLJ10661 -0.45 -6.22 -0.32 1.53e-9 Neuroticism; CRC cis rs3008870 0.755 rs4655661 chr1:67408828 A/C cg08660285 chr1:67390436 MIER1;WDR78 0.54 7.66 0.39 2.15e-13 Lymphocyte percentage of white cells; CRC cis rs1865760 0.827 rs9461227 chr6:25960815 C/T cg17691542 chr6:26056736 HIST1H1C 0.55 8.4 0.42 1.36e-15 Height; CRC cis rs972578 0.837 rs6002966 chr22:43259855 T/C cg01576275 chr22:43409880 NA -0.41 -6.49 -0.34 3.13e-10 Mean platelet volume; CRC cis rs7772486 0.754 rs4896841 chr6:146041522 T/C cg23711669 chr6:146136114 FBXO30 -0.73 -12.51 -0.57 1.22e-29 Lobe attachment (rater-scored or self-reported); CRC cis rs4689592 0.619 rs3796908 chr4:7061378 G/A cg26116260 chr4:7069785 GRPEL1 0.93 13.04 0.58 1.24e-31 Monocyte percentage of white cells; CRC cis rs6121246 0.954 rs6060992 chr20:30431255 G/T cg13852791 chr20:30311386 BCL2L1 0.63 10.07 0.49 5.54e-21 Mean corpuscular hemoglobin; CRC cis rs7849270 1.000 rs3124513 chr9:131904593 C/T cg13538475 chr9:131942899 NA 0.33 6.23 0.33 1.4e-9 Blood metabolite ratios; CRC cis rs4481887 0.927 rs10749651 chr1:248472930 T/C cg13385794 chr1:248469461 NA 0.38 6.75 0.35 6.84e-11 Common traits (Other); CRC cis rs17345786 1.000 rs73863360 chr3:101316837 G/A cg11279151 chr3:101281821 RG9MTD1 -0.7 -8.9 -0.44 3.74e-17 Colonoscopy-negative controls vs population controls; CRC cis rs11997175 0.716 rs7460818 chr8:33816362 A/G ch.8.33884649F chr8:33765107 NA 0.47 6.83 0.35 4.16e-11 Body mass index; CRC cis rs1799949 0.827 rs74252763 chr17:41402020 C/T cg25072359 chr17:41440525 NA 0.46 6.85 0.35 3.59e-11 Menopause (age at onset); CRC cis rs4363385 0.588 rs12082627 chr1:153023650 G/A cg25856811 chr1:152973957 SPRR3 -0.23 -6.18 -0.32 1.94e-9 Inflammatory skin disease; CRC cis rs12477438 0.765 rs12612688 chr2:99613091 C/G cg14399236 chr2:99771627 LIPT1;TSGA10 -0.58 -8.17 -0.41 6.91e-15 Chronic sinus infection; CRC cis rs6951245 0.554 rs76243429 chr7:1152543 C/T cg04025307 chr7:1156635 C7orf50 0.72 9.18 0.45 5.03e-18 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg13959152 chr12:100535986 UHRF1BP1L 0.5 7.12 0.37 6.96e-12 Response to antipsychotic treatment; CRC cis rs2108225 0.872 rs7792139 chr7:107445433 G/A cg18560240 chr7:107437656 SLC26A3 -0.66 -9.96 -0.48 1.37e-20 Ulcerative colitis; CRC cis rs9457247 1.000 rs393727 chr6:167398632 T/A cg23791538 chr6:167370224 RNASET2 -0.39 -6.17 -0.32 2.01e-9 Crohn's disease; CRC cis rs561341 1.000 rs757009 chr17:30243937 A/G cg19193384 chr17:30244184 NA -0.48 -6.49 -0.34 3.2e-10 Hip circumference adjusted for BMI; CRC cis rs769267 0.895 rs2965182 chr19:19548246 A/G cg02546618 chr19:19431379 KIAA0892;SF4 0.46 6.43 0.33 4.59e-10 Tonsillectomy; CRC cis rs10751667 0.643 rs6597970 chr11:928669 C/A ch.11.42038R chr11:967971 AP2A2 0.61 10.16 0.49 2.82e-21 Alzheimer's disease (late onset); CRC cis rs853679 0.517 rs4713146 chr6:28111536 A/T cg12172441 chr6:28176163 NA 0.64 7.53 0.38 5.03e-13 Depression; CRC cis rs8060686 0.858 rs11553287 chr16:67905407 A/G cg26727032 chr16:67993705 SLC12A4 -0.73 -12.04 -0.55 6.33e-28 HDL cholesterol;Metabolic syndrome; CRC cis rs13082711 0.911 rs7650165 chr3:27462440 C/T cg02860705 chr3:27208620 NA 0.6 8.56 0.43 4.28e-16 Systolic blood pressure;Diastolic blood pressure;Blood pressure; CRC cis rs4713118 0.586 rs6905516 chr6:28086478 A/G cg15845792 chr6:28175446 NA 1.0 13.1 0.59 7.81e-32 Parkinson's disease; CRC cis rs4731207 0.535 rs7806126 chr7:124601875 T/C cg23710748 chr7:124431027 NA -0.38 -6.08 -0.32 3.35e-9 Cutaneous malignant melanoma; CRC cis rs1129187 0.934 rs9471974 chr6:42918984 T/A cg09436375 chr6:42928200 GNMT -0.32 -5.99 -0.31 5.41e-9 Alzheimer's disease in APOE e4+ carriers; CRC cis rs4268898 0.686 rs2042468 chr2:24398446 A/T cg06627628 chr2:24431161 ITSN2 0.46 6.7 0.35 9.01e-11 Asthma; CRC cis rs6964587 0.934 rs7793861 chr7:91742728 C/G cg17063962 chr7:91808500 NA 0.81 14.39 0.62 9.35e-37 Breast cancer; CRC cis rs10464366 0.544 rs953874 chr7:39147916 G/A cg18850127 chr7:39170497 POU6F2 0.54 7.36 0.38 1.52e-12 IgG glycosylation; CRC cis rs2361718 0.933 rs8077849 chr17:78104137 C/T cg20811857 chr17:78079795 GAA -0.34 -5.6 -0.3 4.5e-8 Yeast infection; CRC cis rs6445967 1.000 rs11713627 chr3:58306946 T/G cg23715586 chr3:58305044 RPP14 0.36 6.04 0.32 4.12e-9 Platelet count; CRC cis rs6424115 0.729 rs586173 chr1:24055718 A/G cg15997130 chr1:24165203 NA -0.74 -10.94 -0.52 5.91e-24 Immature fraction of reticulocytes; CRC trans rs629535 0.911 rs688612 chr8:70011887 C/T cg21567404 chr3:27674614 NA -0.93 -15.87 -0.66 1.66e-42 Dupuytren's disease; CRC cis rs853679 0.517 rs9295759 chr6:28124469 C/T cg15786705 chr6:28176104 NA 0.78 9.83 0.48 3.57e-20 Depression; CRC trans rs10506458 0.915 rs998505 chr12:63400018 C/T cg03429785 chr15:59498649 MYO1E;LDHAL6B -1.42 -21.1 -0.76 4.36e-63 Hemostatic factors and hematological phenotypes; CRC cis rs1873147 1.000 rs12443285 chr15:63313596 C/T cg12160578 chr15:63334699 TPM1 -0.4 -5.73 -0.3 2.28e-8 Orofacial clefts; CRC cis rs1552244 1.000 rs6789156 chr3:10124120 C/T cg00166722 chr3:10149974 C3orf24 0.65 8.67 0.43 1.95e-16 Alzheimer's disease; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg11940663 chr21:46962454 SLC19A1 0.49 6.7 0.35 8.91e-11 Anxiety disorder; CRC cis rs3820068 0.705 rs11584398 chr1:15880275 G/A cg27534772 chr1:16042836 PLEKHM2 0.42 7.01 0.36 1.32e-11 Systolic blood pressure; CRC cis rs2739330 0.828 rs5760107 chr22:24252597 T/C cg10819733 chr22:24237672 NA -0.35 -5.88 -0.31 1.03e-8 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs11098499 0.909 rs28571712 chr4:120375980 G/A cg24375607 chr4:120327624 NA 0.51 7.87 0.4 5.23e-14 Corneal astigmatism; CRC cis rs9462027 0.628 rs998278 chr6:34765584 G/A cg07306190 chr6:34760872 UHRF1BP1 -0.34 -6.01 -0.31 4.88e-9 Systemic lupus erythematosus; CRC cis rs6570726 0.791 rs12208019 chr6:145935572 T/C cg05347473 chr6:146136440 FBXO30 0.38 5.7 0.3 2.72e-8 Lobe attachment (rater-scored or self-reported); CRC cis rs7659604 1.000 rs28532673 chr4:122664323 A/G cg06713675 chr4:122721982 EXOSC9 0.37 6.01 0.31 4.94e-9 Type 2 diabetes; CRC cis rs208520 0.909 rs60604603 chr6:67022955 T/C cg07460842 chr6:66804631 NA 0.84 9.91 0.48 1.91e-20 Exhaled nitric oxide output; CRC cis rs40363 0.645 rs1690450 chr16:3521051 G/A cg22508957 chr16:3507546 NAT15 0.61 9.78 0.47 5.5e-20 Tuberculosis; CRC cis rs1801251 1.000 rs2012221 chr2:233566848 T/C cg25237894 chr2:233734115 C2orf82 0.49 8.03 0.4 1.73e-14 Coronary artery disease; CRC cis rs12188164 0.686 rs72711365 chr5:416672 G/A cg17553881 chr5:443987 EXOC3;C5orf55 -0.34 -7.14 -0.37 6.05e-12 Cystic fibrosis severity; CRC cis rs1448094 0.512 rs7133591 chr12:86239752 G/C cg19622623 chr12:86230825 RASSF9 -0.41 -6.73 -0.35 7.69e-11 Major depressive disorder; CRC cis rs6121246 0.738 rs2376996 chr20:30316667 T/A cg13852791 chr20:30311386 BCL2L1 0.69 11.53 0.54 4.52e-26 Mean corpuscular hemoglobin; CRC cis rs9322193 0.962 rs9322206 chr6:149962617 T/C cg05861140 chr6:150128134 PCMT1 -0.44 -7.06 -0.36 9.86e-12 Lung cancer; CRC trans rs61931739 0.534 rs1352206 chr12:34036668 G/A cg26384229 chr12:38710491 ALG10B 0.51 6.88 0.35 3.1e-11 Morning vs. evening chronotype; CRC cis rs7591163 1.000 rs940341 chr2:228724726 A/G cg14329157 chr2:228736135 WDR69 -0.45 -6.21 -0.32 1.56e-9 Blood pressure; CRC cis rs1448094 0.556 rs11610627 chr12:86167752 C/T cg19622623 chr12:86230825 RASSF9 -0.37 -5.64 -0.3 3.62e-8 Major depressive disorder; CRC cis rs1552244 1.000 rs12152515 chr3:10143976 C/T cg02579736 chr3:10068473 FANCD2;CIDECP 0.9 12.45 0.57 1.98e-29 Alzheimer's disease; CRC cis rs9876781 0.933 rs6442124 chr3:48505302 A/G cg06066452 chr3:48470258 PLXNB1 0.21 5.61 0.3 4.28e-8 Longevity; CRC trans rs11712655 0.961 rs9881700 chr3:135229503 A/C cg14625040 chr2:6214447 NA 0.44 6.09 0.32 3.22e-9 Visceral adipose tissue/subcutaneous adipose tissue ratio; CRC cis rs2580764 0.516 rs2860453 chr2:55270485 T/G cg09592903 chr2:55203963 RTN4 0.71 11.55 0.54 4.04e-26 Mean platelet volume; CRC cis rs4713118 0.869 rs9283883 chr6:27715470 T/A cg21251018 chr6:28226885 NKAPL 0.38 5.66 0.3 3.21e-8 Parkinson's disease; CRC cis rs853679 0.517 rs9357065 chr6:28129580 T/C cg02631126 chr6:28058918 ZSCAN12L1 0.3 5.95 0.31 6.76e-9 Depression; CRC cis rs2243480 1.000 rs1715235 chr7:65488394 T/C cg18252515 chr7:66147081 NA -1.1 -12.3 -0.56 7.15e-29 Diabetic kidney disease; CRC cis rs7552404 0.855 rs385897 chr1:76106962 T/C cg10523679 chr1:76189770 ACADM -0.83 -11.3 -0.53 3.14e-25 Blood metabolite levels;Acylcarnitine levels; CRC trans rs8002861 0.905 rs12853286 chr13:44446817 A/G cg17145862 chr1:211918768 LPGAT1 -0.72 -13.13 -0.59 5.77e-32 Leprosy; CRC trans rs2727020 0.754 rs1851990 chr11:49413336 C/T cg03929089 chr4:120376271 NA -0.8 -11.46 -0.53 8.11e-26 Coronary artery disease; CRC cis rs7945718 0.875 rs9888181 chr11:12782781 G/A cg25843174 chr11:12811716 TEAD1 0.51 9.87 0.48 2.76e-20 Educational attainment (years of education); CRC cis rs853679 0.517 rs3757187 chr6:28107654 T/C cg12963246 chr6:28129442 ZNF389 0.49 5.78 0.3 1.73e-8 Depression; CRC cis rs5753618 0.509 rs1034589 chr22:31579233 C/T cg22777020 chr22:31556080 RNF185 -0.52 -6.14 -0.32 2.4e-9 Colorectal cancer; CRC cis rs12024301 0.557 rs10911383 chr1:183603962 G/A cg11505048 chr1:183622726 RGL1;APOBEC4 0.75 6.81 0.35 4.6e-11 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs9322193 0.962 rs4869966 chr6:150084850 A/G cg13206674 chr6:150067644 NUP43 0.57 8.19 0.41 5.85e-15 Lung cancer; CRC cis rs3087591 1.000 rs2057769 chr17:29691368 C/A cg24425628 chr17:29625626 OMG;NF1 -0.84 -16.3 -0.67 3.3e-44 Hip circumference; CRC cis rs1862618 0.713 rs832550 chr5:56182589 C/T cg12311346 chr5:56204834 C5orf35 -0.79 -10.04 -0.48 7.48e-21 Initial pursuit acceleration; CRC cis rs34779708 0.966 rs10827493 chr10:35454976 C/T cg03585969 chr10:35415529 CREM 0.57 7.63 0.39 2.58e-13 Inflammatory bowel disease;Crohn's disease; CRC cis rs35146811 0.844 rs34031156 chr7:99677917 T/A cg13334819 chr7:99746414 C7orf59 -0.5 -7.09 -0.36 8.34e-12 Coronary artery disease; CRC cis rs2811415 0.597 rs67527747 chr3:127803083 G/A cg13719885 chr3:127795394 NA -0.4 -6.0 -0.31 5.26e-9 Lung function (FEV1/FVC); CRC cis rs11645898 1.000 rs72791115 chr16:72207315 T/C cg14768367 chr16:72042858 DHODH -0.61 -6.74 -0.35 7.21e-11 Blood protein levels; CRC cis rs887829 0.570 rs10445704 chr2:234600274 G/A cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.45 -7.06 -0.36 9.85e-12 Metabolic traits;Bilirubin levels;Cholelithiasis-related traits in sickle cell anemia;Metabolite levels;Total bilirubin levels in HIV-1 infection;Serum metabolite levels;Blood metabolite levels; CRC cis rs2842992 0.724 rs9347340 chr6:160188891 C/T cg19482086 chr6:160211437 TCP1;MRPL18 -0.83 -13.39 -0.59 6.16e-33 Age-related macular degeneration (geographic atrophy); CRC cis rs12188164 1.000 rs56104584 chr5:437542 T/C cg17553881 chr5:443987 EXOC3;C5orf55 -0.36 -7.56 -0.38 4.07e-13 Cystic fibrosis severity; CRC cis rs9457247 0.663 rs9457258 chr6:167444254 T/C cg07741184 chr6:167504864 NA 0.35 6.32 0.33 8.58e-10 Crohn's disease; CRC cis rs9487051 0.872 rs9487043 chr6:109610474 C/T cg21918786 chr6:109611834 NA -0.46 -8.42 -0.42 1.17e-15 Reticulocyte fraction of red cells; CRC cis rs7945705 0.967 rs10840141 chr11:8902218 T/C cg21881798 chr11:8931708 C11orf17;ST5 0.68 10.76 0.51 2.44e-23 Hemoglobin concentration; CRC cis rs4604732 0.631 rs75320597 chr1:247626751 T/G cg12754571 chr1:247694271 LOC148824;OR2C3 0.41 5.78 0.3 1.74e-8 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CRC cis rs4713118 0.512 rs2622319 chr6:28120401 G/C cg06470822 chr6:28175283 NA 0.82 12.06 0.55 5.37e-28 Parkinson's disease; CRC cis rs951366 0.789 rs823110 chr1:205701078 G/C cg23034840 chr1:205782522 SLC41A1 0.47 6.53 0.34 2.55e-10 Menarche (age at onset); CRC cis rs427941 0.632 rs201527 chr7:101774451 T/C cg06246474 chr7:101738831 CUX1 0.45 6.9 0.36 2.72e-11 Plasma omega-3 polyunsaturated fatty acid level (eicosapentaenoic acid); CRC cis rs10503871 0.545 rs16877238 chr8:30503371 A/G cg26383811 chr8:30366931 RBPMS -0.38 -5.63 -0.3 3.88e-8 Metabolite levels (X-11787); CRC cis rs2839186 0.708 rs17183123 chr21:47671961 G/C cg11766577 chr21:47581405 C21orf56 -0.46 -7.36 -0.38 1.53e-12 Testicular germ cell tumor; CRC cis rs2354432 0.556 rs57388899 chr1:146773422 T/C cg25205988 chr1:146714368 CHD1L -1.1 -11.94 -0.55 1.52e-27 Mitochondrial DNA levels; CRC cis rs9486719 0.843 rs2499787 chr6:96841762 G/C cg06623918 chr6:96969491 KIAA0776 0.78 8.28 0.42 3.05e-15 Migraine;Coronary artery disease; CRC cis rs4862750 0.872 rs6821507 chr4:187876829 G/T cg03452623 chr4:187889614 NA 0.9 21.1 0.76 4.03e-63 Lobe attachment (rater-scored or self-reported); CRC cis rs9393777 0.557 rs7759741 chr6:27241043 C/T cg12292205 chr6:26970375 C6orf41 -0.79 -8.56 -0.43 4.3e-16 Intelligence (multi-trait analysis); CRC cis rs2976388 0.609 rs2717550 chr8:143787808 T/A cg15511327 chr8:143859410 LYNX1 0.42 7.46 0.38 7.98e-13 Urinary tract infection frequency; CRC cis rs951366 0.617 rs823075 chr1:205774897 C/T cg24739457 chr1:205821442 NA 0.44 6.44 0.33 4.18e-10 Menarche (age at onset); CRC cis rs208520 0.690 rs2126120 chr6:66742754 A/G cg07460842 chr6:66804631 NA 1.06 14.78 0.63 2.91e-38 Exhaled nitric oxide output; CRC trans rs3733585 0.624 rs76574510 chr4:9953252 T/A cg26043149 chr18:55253948 FECH -0.5 -7.71 -0.39 1.51e-13 Cleft plate (environmental tobacco smoke interaction); CRC cis rs11690935 1.000 rs6433311 chr2:172549248 A/G cg13550731 chr2:172543902 DYNC1I2 1.07 19.18 0.73 1.48e-55 Schizophrenia; CRC cis rs4654899 0.802 rs2167811 chr1:21194510 A/G cg02927042 chr1:21476669 EIF4G3 0.44 7.06 0.36 9.77e-12 Superior frontal gyrus grey matter volume; CRC cis rs17345786 0.953 rs78645744 chr3:101327789 T/A cg11279151 chr3:101281821 RG9MTD1 -0.68 -8.48 -0.42 7.56e-16 Colonoscopy-negative controls vs population controls; CRC cis rs2249625 0.545 rs2496488 chr6:72875985 A/T cg18830697 chr6:72922368 RIMS1 -0.39 -7.92 -0.4 3.81e-14 Acute urticaria and angioedema (non-steroidal anti-inflammatory drug-induced); CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg00704288 chr1:44172956 ST3GAL3 0.5 6.38 0.33 6.02e-10 Thyroid stimulating hormone; CRC cis rs938554 0.570 rs7696983 chr4:9995829 A/C cg00071950 chr4:10020882 SLC2A9 0.5 6.86 0.35 3.52e-11 Blood metabolite levels; CRC cis rs9517313 0.897 rs4772087 chr13:99115041 A/G cg20487152 chr13:99095054 FARP1 0.49 7.7 0.39 1.5700000000000001e-13 Neuroticism; CRC cis rs892961 0.932 rs7224116 chr17:75413177 A/G cg05865280 chr17:75406074 SEPT9 0.63 14.51 0.62 3.27e-37 Airflow obstruction; CRC cis rs738322 1.000 rs133012 chr22:38570721 G/A cg17652424 chr22:38574118 PLA2G6 -0.22 -6.73 -0.35 7.71e-11 Cutaneous nevi; CRC trans rs11088226 0.681 rs2833901 chr21:33939318 T/C cg09050820 chr6:167586206 TCP10L2 0.84 8.89 0.44 4.02e-17 Gastritis; CRC trans rs1005277 0.579 rs2474567 chr10:38382492 C/T cg23533926 chr12:111358616 MYL2 -0.52 -7.84 -0.4 6.24e-14 Extrinsic epigenetic age acceleration; CRC cis rs7089973 0.836 rs7895551 chr10:116625481 C/T cg03647239 chr10:116582469 FAM160B1 0.41 5.79 0.3 1.67e-8 Bipolar disorder or attention deficit hyperactivity disorder; CRC trans rs3780486 0.813 rs3780488 chr9:33133812 T/C cg04842962 chr6:43655489 MRPS18A 1.14 23.8 0.8 1.56e-73 IgG glycosylation; CRC cis rs995000 0.931 rs637723 chr1:62906728 C/T cg19896129 chr1:63156450 NA 0.44 6.84 0.35 3.76e-11 Triglyceride levels; CRC cis rs9611565 0.659 rs4822034 chr22:41931010 T/C cg17554472 chr22:41940697 POLR3H -0.55 -5.93 -0.31 7.73e-9 Vitiligo; CRC cis rs2380220 0.872 rs7750757 chr6:95997118 A/G cg07718321 chr6:96025334 MANEA 0.52 6.13 0.32 2.57e-9 Behavioural disinhibition (generation interaction); CRC cis rs9796 0.621 rs690733 chr15:41476465 G/A cg18705301 chr15:41695430 NDUFAF1 -0.42 -6.98 -0.36 1.6e-11 Menopause (age at onset); CRC cis rs1158570 0.564 rs2791343 chr8:131316030 C/T cg21674704 chr8:131455249 NA 0.38 5.67 0.3 3.1e-8 Platelet count; CRC cis rs6598955 0.670 rs3795685 chr1:26601385 A/G cg00852783 chr1:26633632 UBXN11 -0.43 -7.07 -0.36 9.27e-12 Obesity-related traits; CRC cis rs11098499 0.570 rs6832740 chr4:120546136 T/C cg09307838 chr4:120376055 NA 0.61 9.27 0.46 2.51e-18 Corneal astigmatism; CRC cis rs10504229 0.683 rs16921817 chr8:58107563 A/T cg02290350 chr8:58132656 NA -0.59 -8.02 -0.4 1.88e-14 Developmental language disorder (linguistic errors); CRC cis rs12681287 0.640 rs6471314 chr8:87400459 G/A cg27223183 chr8:87520930 FAM82B 0.52 7.14 0.37 5.97e-12 Caudate activity during reward; CRC cis rs13256369 0.802 rs1060106 chr8:8561452 A/G cg06671706 chr8:8559999 CLDN23 0.61 9.04 0.45 1.35e-17 Obesity-related traits; CRC cis rs7647973 0.600 rs11920267 chr3:49275964 G/A cg20833759 chr3:49053208 WDR6;DALRD3 0.41 6.69 0.35 9.55e-11 Menarche (age at onset); CRC cis rs73200209 0.744 rs73198040 chr12:116535736 G/C cg01776926 chr12:116560359 MED13L -0.58 -6.72 -0.35 8e-11 Total body bone mineral density; CRC cis rs1580019 0.563 rs13225132 chr7:32800975 A/G cg07520158 chr7:32535189 LSM5;AVL9 0.53 7.41 0.38 1.08e-12 Cognitive ability; CRC cis rs651907 0.557 rs34947019 chr3:101532235 C/T cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.59 7.81 0.4 7.69e-14 Colorectal cancer; CRC cis rs2949837 0.581 rs2960436 chr7:45977282 G/A cg23193639 chr7:45961078 IGFBP3 0.4 6.66 0.34 1.14e-10 Sitting height ratio; CRC cis rs6952808 1.000 rs6978048 chr7:1886872 T/G cg20295408 chr7:1910781 MAD1L1 -0.45 -6.25 -0.33 1.27e-9 Bipolar disorder and schizophrenia; CRC cis rs12086130 0.892 rs57331401 chr1:51451372 G/A cg07174182 chr1:51127561 FAF1 -0.72 -5.61 -0.3 4.26e-8 Hip circumference adjusted for BMI;Hip circumference; CRC cis rs10979 0.597 rs9390118 chr6:143907610 A/G cg25407410 chr6:143891975 LOC285740 -0.62 -8.3 -0.42 2.67e-15 Hypospadias; CRC cis rs13108904 0.539 rs13145722 chr4:1338422 T/A cg00684032 chr4:1343700 KIAA1530 0.6 8.36 0.42 1.81e-15 Obesity-related traits; CRC cis rs1348850 0.574 rs11889488 chr2:178426793 A/G cg27490568 chr2:178487706 NA -0.67 -8.01 -0.4 1.98e-14 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC trans rs951252 0.504 rs11734405 chr4:146081096 C/T cg15985338 chr7:6048868 PMS2;AIMP2 0.46 6.08 0.32 3.26e-9 Hip circumference; CRC cis rs10504229 0.683 rs7459925 chr8:58111771 G/A cg02725872 chr8:58115012 NA -0.66 -11.64 -0.54 1.83e-26 Developmental language disorder (linguistic errors); CRC cis rs896854 0.654 rs13274945 chr8:95986626 C/T cg23172400 chr8:95962367 TP53INP1 -0.47 -7.96 -0.4 2.79e-14 Type 2 diabetes; CRC cis rs7605827 0.930 rs2058869 chr2:15679700 T/C cg19274914 chr2:15703543 NA 0.39 5.82 0.31 1.4e-8 Educational attainment (years of education); CRC cis rs7811142 0.720 rs7795656 chr7:99950297 A/T cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.09 15.66 0.65 1.11e-41 Platelet count; CRC cis rs798554 0.679 rs1636254 chr7:2885724 T/C cg04166393 chr7:2884313 GNA12 0.54 7.42 0.38 1.01e-12 Height; CRC cis rs1448094 0.511 rs17280643 chr12:86210154 C/T cg00310523 chr12:86230176 RASSF9 -0.36 -6.13 -0.32 2.55e-9 Major depressive disorder; CRC cis rs9359856 0.564 rs61739327 chr6:90340446 C/T cg13799429 chr6:90582589 CASP8AP2 -0.75 -7.74 -0.39 1.24e-13 Bipolar disorder; CRC cis rs896854 0.738 rs527234 chr8:95963798 C/G cg23172400 chr8:95962367 TP53INP1 0.4 6.11 0.32 2.88e-9 Type 2 diabetes; CRC cis rs10504229 0.906 rs73607868 chr8:58172482 T/C cg02290350 chr8:58132656 NA -0.42 -5.96 -0.31 6.62e-9 Developmental language disorder (linguistic errors); CRC cis rs9309711 0.961 rs11675119 chr2:3476422 C/A cg10845886 chr2:3471009 TTC15 -0.72 -11.6 -0.54 2.56e-26 Neurofibrillary tangles; CRC cis rs2303745 0.589 rs1864115 chr19:17393327 G/C cg15110403 chr19:17392923 ANKLE1 -0.36 -6.0 -0.31 5.23e-9 Systemic lupus erythematosus; CRC cis rs7617773 0.780 rs4511915 chr3:48343858 G/A cg11946769 chr3:48343235 NME6 0.72 9.63 0.47 1.74e-19 Coronary artery disease; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg12785122 chr17:10601181 C17orf48;SCO1 0.4 6.21 0.32 1.61e-9 Intelligence (multi-trait analysis); CRC cis rs2404602 0.692 rs35395069 chr15:76986334 C/T cg03037974 chr15:76606532 NA 0.69 12.09 0.55 4.35e-28 Blood metabolite levels; CRC cis rs3806843 0.966 rs2563262 chr5:140137712 C/G cg16607685 chr5:140181889 PCDHA2;PCDHA1;PCDHA3 0.26 5.99 0.31 5.59e-9 Depressive symptoms (multi-trait analysis); CRC trans rs3942852 0.869 rs4752806 chr11:48118199 G/C cg03929089 chr4:120376271 NA -0.52 -6.41 -0.33 5.04e-10 Acute lymphoblastic leukemia (childhood); CRC cis rs9291683 0.632 rs11734375 chr4:10046298 A/G cg00071950 chr4:10020882 SLC2A9 0.67 12.66 0.57 3.38e-30 Bone mineral density; CRC cis rs4665809 1.000 rs4665299 chr2:26256840 A/C cg04944784 chr2:26401820 FAM59B -0.65 -7.97 -0.4 2.56e-14 Gut microbiome composition (summer); CRC cis rs72627123 0.867 rs73303107 chr14:74477284 A/G cg12022184 chr14:74485813 ENTPD5;C14orf45 0.71 5.81 0.3 1.5e-8 Morning vs. evening chronotype; CRC cis rs775227 0.574 rs13083453 chr3:113096943 G/A cg18753928 chr3:113234510 CCDC52 -0.55 -6.71 -0.35 8.41e-11 Dental caries; CRC cis rs11123170 0.543 rs12472361 chr2:113980645 C/G cg12889195 chr2:113992843 PAX8;LOC440839;LOC654433 0.5 5.87 0.31 1.06e-8 Renal function-related traits (BUN); CRC cis rs9658691 0.920 rs72809360 chr10:90746990 G/T cg03111039 chr10:90751583 FAS;ACTA2 -0.87 -6.3 -0.33 9.41e-10 Mosquito bite size; CRC cis rs9916302 0.706 rs12937013 chr17:37665571 G/A cg20243544 chr17:37824526 PNMT 0.47 5.61 0.3 4.22e-8 Glomerular filtration rate (creatinine); CRC cis rs1882538 0.901 rs35284403 chr7:132948884 T/C cg10665199 chr7:133106180 EXOC4 0.51 7.22 0.37 3.69e-12 Intelligence (multi-trait analysis); CRC cis rs7945705 0.935 rs11042102 chr11:8882164 C/T cg21881798 chr11:8931708 C11orf17;ST5 0.66 10.12 0.49 4.04e-21 Hemoglobin concentration; CRC cis rs7584330 0.780 rs10176842 chr2:238428256 T/C cg14458575 chr2:238380390 NA 0.45 7.75 0.39 1.13e-13 Prostate cancer; CRC cis rs3733585 0.699 rs7676733 chr4:9966956 G/A cg11266682 chr4:10021025 SLC2A9 -0.47 -9.55 -0.47 3.01e-19 Cleft plate (environmental tobacco smoke interaction); CRC cis rs7208859 0.573 rs11654035 chr17:29136426 T/C cg01831904 chr17:28903510 LRRC37B2 -0.66 -6.73 -0.35 7.62e-11 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs6121246 0.567 rs6060295 chr20:30198473 C/T cg13852791 chr20:30311386 BCL2L1 0.61 8.29 0.42 2.84e-15 Mean corpuscular hemoglobin; CRC cis rs11212617 1.000 rs11212615 chr11:108281267 G/A cg01991180 chr11:108092276 ATM;NPAT 0.42 6.09 0.32 3.2e-9 Response to metformin in type 2 diabetes (glycemic); CRC cis rs739401 0.611 rs7130841 chr11:3043658 A/G cg08508325 chr11:3079039 CARS -0.5 -9.28 -0.46 2.33e-18 Longevity; CRC cis rs4713118 0.662 rs469228 chr6:27970704 A/G cg12273811 chr6:28175739 NA 0.6 8.82 0.44 7e-17 Parkinson's disease; CRC cis rs57221529 0.713 rs12521091 chr5:590710 G/T cg17948913 chr5:572064 NA 0.54 6.07 0.32 3.57e-9 Lung disease severity in cystic fibrosis; CRC trans rs4576506 0.536 rs71512719 chr9:31496127 T/A cg26940518 chr16:1593766 IFT140;TMEM204 -0.65 -6.02 -0.31 4.71e-9 Psychosis and Alzheimer's disease; CRC cis rs889398 0.802 rs12925700 chr16:69793463 C/A cg00738113 chr16:70207722 CLEC18C 0.37 6.22 0.32 1.5e-9 Body mass index; CRC cis rs10782582 0.593 rs77733234 chr1:76101655 A/T cg03433033 chr1:76189801 ACADM -0.44 -6.38 -0.33 6.15e-10 Daytime sleep phenotypes; CRC cis rs875971 0.638 rs6460305 chr7:66060408 G/A cg00343986 chr7:65444356 GUSB -0.5 -7.51 -0.38 5.69e-13 Aortic root size; CRC cis rs7666738 0.830 rs957742 chr4:99029409 C/T cg17366294 chr4:99064904 C4orf37 0.44 7.48 0.38 6.96e-13 Colonoscopy-negative controls vs population controls; CRC trans rs9956878 0.555 rs8085188 chr18:73544676 A/G cg03744954 chr7:23637556 CCDC126 -0.36 -6.06 -0.32 3.73e-9 Obesity-related traits; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg05067136 chr7:23338802 C7orf30 0.46 6.3 0.33 9.45e-10 Response to antipsychotic treatment; CRC cis rs798554 0.759 rs1182189 chr7:2869522 G/A cg19717773 chr7:2847554 GNA12 -0.47 -6.57 -0.34 1.98e-10 Height; CRC cis rs2952156 0.883 rs8077172 chr17:37834977 G/T cg11212589 chr17:38028394 ZPBP2 0.35 6.15 0.32 2.26e-9 Asthma; CRC cis rs4713118 0.662 rs9468278 chr6:28028482 C/T cg02683197 chr6:28174875 NA 0.75 9.78 0.47 5.25e-20 Parkinson's disease; CRC cis rs9287719 0.967 rs11674433 chr2:10730839 T/C cg00105475 chr2:10696890 NA 0.45 7.26 0.37 2.75e-12 Prostate cancer; CRC cis rs6499255 1.000 rs4464069 chr16:69816284 C/T cg04110750 chr16:69646130 NFAT5 -0.5 -6.95 -0.36 1.94e-11 IgE levels; CRC cis rs2932538 0.922 rs12138335 chr1:113122760 T/C cg22162597 chr1:113214053 CAPZA1 0.71 10.11 0.49 4.32e-21 Systolic blood pressure;Diastolic blood pressure;Hypertension;Blood pressure; CRC cis rs3820068 0.581 rs6693694 chr1:15980135 G/T cg24675056 chr1:15929824 NA 0.53 7.18 0.37 4.76e-12 Systolic blood pressure; CRC cis rs6460942 0.915 rs17324858 chr7:12305792 G/T cg06484146 chr7:12443880 VWDE -0.52 -6.96 -0.36 1.91e-11 Coronary artery disease; CRC trans rs703108 0.731 rs7898954 chr10:22323646 A/G cg13489040 chr1:152162507 NA -0.5 -6.08 -0.32 3.31e-9 Monocyte percentage of white cells; CRC cis rs2243480 1.000 rs4718316 chr7:65648731 A/G cg25985355 chr7:65971099 NA 0.52 6.01 0.31 4.92e-9 Diabetic kidney disease; CRC cis rs7618915 1.000 rs3852063 chr3:52349204 A/G cg18404041 chr3:52824283 ITIH1 -0.4 -7.31 -0.37 2e-12 Bipolar disorder; CRC cis rs449789 0.524 rs4345420 chr6:159745037 G/A cg14500486 chr6:159655392 FNDC1 -0.51 -7.76 -0.39 1.05e-13 Pulse pressure; CRC cis rs9938149 0.736 rs6540223 chr16:88321436 A/G cg05435882 chr16:88311214 NA 0.44 5.96 0.31 6.48e-9 Corneal structure;Central corneal thickness; CRC cis rs11758351 0.660 rs55848726 chr6:26224434 T/C cg10723962 chr6:26240782 HIST1H4F -0.38 -6.09 -0.32 3.14e-9 Gout;Renal underexcretion gout; CRC cis rs4604732 0.588 rs7552443 chr1:247628583 G/T cg12758973 chr1:247694275 LOC148824;OR2C3 0.38 5.75 0.3 2.03e-8 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CRC cis rs7793919 0.726 rs10232008 chr7:4783206 T/G cg09789173 chr7:4769017 FOXK1 0.76 12.55 0.57 8.45e-30 Mosquito bite size; CRC cis rs9910055 0.821 rs4473241 chr17:42281282 G/T cg13607699 chr17:42295918 UBTF 0.5 7.27 0.37 2.57e-12 Total body bone mineral density; CRC cis rs1005224 0.782 rs34882722 chr14:76153896 C/T cg04684003 chr14:76127793 TTLL5;C14orf1 -0.45 -6.39 -0.33 5.67e-10 Large artery stroke; CRC cis rs629535 0.862 rs654604 chr8:70048939 C/A cg26132723 chr8:70041827 NA 0.35 5.72 0.3 2.41e-8 Dupuytren's disease; CRC cis rs881375 1.000 rs1609810 chr9:123642351 C/T cg14255062 chr9:123606675 PSMD5;LOC253039 0.42 6.11 0.32 2.81e-9 Rheumatoid arthritis; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg21810621 chr11:1331345 LOC255512;TOLLIP -0.41 -6.17 -0.32 2.01e-9 Myopia (pathological); CRC trans rs2797160 0.935 rs1739379 chr6:126012593 T/C cg05039488 chr6:79577232 IRAK1BP1 0.51 7.58 0.39 3.52e-13 Endometrial cancer; CRC cis rs6912958 0.712 rs2814712 chr6:88396322 A/C cg12350822 chr6:88032061 C6orf162;GJB7 0.34 6.47 0.34 3.6e-10 Monocyte percentage of white cells; CRC cis rs9611565 0.765 rs132906 chr22:41799767 G/C cg03806693 chr22:41940476 POLR3H 0.77 10.41 0.5 3.94e-22 Vitiligo; CRC trans rs453301 0.686 rs6987107 chr8:8893581 A/G cg16141378 chr3:129829833 LOC729375 0.42 6.31 0.33 9.1e-10 Joint mobility (Beighton score); CRC cis rs4731207 0.570 rs2086505 chr7:124664157 A/T cg23710748 chr7:124431027 NA -0.43 -6.73 -0.35 7.69e-11 Cutaneous malignant melanoma; CRC cis rs1552244 1.000 rs7615646 chr3:10089773 A/C cg18598329 chr3:10140678 FANCD2;C3orf24 -0.87 -11.82 -0.55 4.24e-27 Alzheimer's disease; CRC cis rs9303401 0.659 rs35103007 chr17:56900738 G/A cg02118635 chr17:56770003 RAD51C;TEX14 0.78 9.9 0.48 2.17e-20 Cognitive test performance; CRC cis rs6840360 0.571 rs11939356 chr4:152505234 G/C cg09659197 chr4:152720779 NA 0.32 5.77 0.3 1.84e-8 Intelligence (multi-trait analysis); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg19518383 chr11:64577818 MEN1 0.4 6.06 0.32 3.8e-9 Intelligence (multi-trait analysis); CRC cis rs9292777 0.518 rs6871834 chr5:40480187 C/T cg09067459 chr5:40385259 NA 0.38 6.16 0.32 2.12e-9 Crohn's disease;Multiple sclerosis; CRC cis rs9902453 0.904 rs9900974 chr17:28364456 C/T cg26525008 chr17:28256777 EFCAB5;SSH2 -0.69 -11.18 -0.52 8.09e-25 Coffee consumption (cups per day); CRC cis rs7659604 0.540 rs11724322 chr4:122697850 A/T cg19748678 chr4:122722346 EXOSC9 -0.46 -6.26 -0.33 1.21e-9 Type 2 diabetes; CRC cis rs1552244 0.810 rs7612908 chr3:10089148 A/G cg08888203 chr3:10149979 C3orf24 0.73 10.16 0.49 2.86e-21 Alzheimer's disease; CRC cis rs11098499 0.863 rs6534141 chr4:120485223 A/T cg09307838 chr4:120376055 NA 0.67 10.04 0.48 7.41e-21 Corneal astigmatism; CRC cis rs7619833 0.607 rs7634878 chr3:27241219 C/T cg02860705 chr3:27208620 NA 0.36 5.89 0.31 9.74e-9 Breast cancer; CRC cis rs782590 0.643 rs13032503 chr2:55739093 C/T cg18811423 chr2:55921094 PNPT1 -0.67 -10.22 -0.49 1.79e-21 Metabolic syndrome; CRC cis rs780096 0.546 rs715325 chr2:27725572 C/A cg17158414 chr2:27665306 KRTCAP3 -0.28 -6.01 -0.31 4.9e-9 Total body bone mineral density; CRC cis rs7927771 1.000 rs11039412 chr11:47841581 G/A cg20307385 chr11:47447363 PSMC3 -0.49 -6.51 -0.34 2.86e-10 Subjective well-being; CRC cis rs875971 0.964 rs778721 chr7:65845397 C/G cg18876405 chr7:65276391 NA 0.52 9.04 0.45 1.37e-17 Aortic root size; CRC cis rs10191773 0.589 rs11691239 chr2:112950600 A/C cg24977338 chr2:113188963 RGPD8;RGPD5 0.6 5.76 0.3 1.94e-8 Yeast infection; CRC cis rs7264396 0.623 rs2425123 chr20:34329547 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.48 -6.57 -0.34 1.92e-10 Total cholesterol levels; CRC cis rs72634258 0.945 rs34124834 chr1:8028930 T/G cg00042356 chr1:8021962 PARK7 0.71 7.46 0.38 7.93e-13 Inflammatory bowel disease; CRC cis rs10504229 0.683 rs62621195 chr8:58133964 G/A cg04204079 chr8:58130323 NA -0.45 -5.78 -0.3 1.71e-8 Developmental language disorder (linguistic errors); CRC cis rs9372498 0.536 rs72952761 chr6:118866758 A/C cg07617317 chr6:118971624 C6orf204 0.5 6.21 0.32 1.56e-9 Diastolic blood pressure; CRC cis rs9549367 0.713 rs4907598 chr13:113861385 C/T cg18105134 chr13:113819100 PROZ 0.83 12.82 0.58 8.29e-31 Platelet distribution width; CRC cis rs9914988 0.887 rs7213285 chr17:27206029 G/A cg16670446 chr17:27188758 MIR451;MIR144 0.51 6.35 0.33 7.22e-10 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs4713118 0.513 rs156739 chr6:28013410 C/A cg12273811 chr6:28175739 NA 0.57 8.21 0.41 5.09e-15 Parkinson's disease; CRC cis rs1881797 0.932 rs2387038 chr1:247674919 G/A cg18198730 chr1:247681584 NA 0.57 8.55 0.43 4.84e-16 Acute lymphoblastic leukemia (childhood); CRC cis rs6951245 0.580 rs78894484 chr7:1138721 T/G cg04025307 chr7:1156635 C7orf50 0.66 8.25 0.41 3.76e-15 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs7666738 0.924 rs62318940 chr4:99064768 C/T cg03676636 chr4:99064102 C4orf37 0.23 6.27 0.33 1.16e-9 Colonoscopy-negative controls vs population controls; CRC cis rs1008375 1.000 rs11737138 chr4:17657986 G/A cg16339924 chr4:17578868 LAP3 0.59 8.08 0.41 1.26e-14 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs11785693 0.862 rs62491200 chr8:4998001 A/C cg26367366 chr8:4980734 NA 0.79 9.58 0.47 2.55e-19 Neuroticism (multi-trait analysis);Neuroticism; CRC cis rs875971 0.862 rs801206 chr7:66021966 C/G cg18252515 chr7:66147081 NA 0.43 6.21 0.32 1.62e-9 Aortic root size; CRC cis rs10504229 0.645 rs56670121 chr8:58138872 C/T cg04204079 chr8:58130323 NA -0.45 -5.76 -0.3 1.91e-8 Developmental language disorder (linguistic errors); CRC cis rs116095464 0.558 rs10065239 chr5:275288 C/T cg22496380 chr5:211416 CCDC127 -0.98 -9.66 -0.47 1.3e-19 Breast cancer; CRC cis rs2985684 0.894 rs4900928 chr14:50020817 A/G cg04989706 chr14:50066350 PPIL5 -0.6 -8.74 -0.43 1.23e-16 Carotid intima media thickness; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg04060830 chr9:132816023 GPR107 0.45 6.15 0.32 2.19e-9 Response to antipsychotic treatment; CRC cis rs6879260 1.000 rs729568 chr5:179732350 C/T cg26918954 chr5:179728553 GFPT2 0.41 6.81 0.35 4.56e-11 Height; CRC cis rs67311347 1.000 rs977652 chr3:40479169 A/G cg09455208 chr3:40491958 NA 0.44 8.98 0.44 2.18e-17 Renal cell carcinoma; CRC cis rs10193935 0.901 rs17029411 chr2:42479149 G/A cg27598129 chr2:42591480 NA -0.53 -6.45 -0.33 4.05e-10 Colonoscopy-negative controls vs population controls; CRC cis rs2882667 0.861 rs10043676 chr5:138389561 C/T cg09476006 chr5:138032270 NA 0.43 7.26 0.37 2.89e-12 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs1552244 1.000 rs17032277 chr3:10077023 T/C cg00166722 chr3:10149974 C3orf24 0.71 9.49 0.46 4.86e-19 Alzheimer's disease; CRC cis rs3750082 0.889 rs12154586 chr7:32923371 T/C cg05721444 chr7:32995514 FKBP9 0.5 7.76 0.39 1.12e-13 Glomerular filtration rate (creatinine); CRC cis rs7666738 0.830 rs6819047 chr4:98866902 G/A cg17366294 chr4:99064904 C4orf37 0.41 6.67 0.35 1.08e-10 Colonoscopy-negative controls vs population controls; CRC cis rs951366 0.585 rs72750964 chr1:205675240 C/T cg07157834 chr1:205819609 PM20D1 0.77 11.26 0.53 4.39e-25 Menarche (age at onset); CRC cis rs9549260 0.755 rs4429172 chr13:41189143 C/A cg21288729 chr13:41239152 FOXO1 0.41 6.44 0.33 4.29e-10 Red blood cell count; CRC cis rs7552404 0.731 rs11161857 chr1:76370228 G/C cg03433033 chr1:76189801 ACADM 0.73 8.83 0.44 6.36e-17 Blood metabolite levels;Acylcarnitine levels; CRC cis rs4713118 0.955 rs9393847 chr6:27687973 G/A cg12273811 chr6:28175739 NA 0.53 7.19 0.37 4.49e-12 Parkinson's disease; CRC cis rs854765 0.624 rs9899634 chr17:17727943 A/T cg16928487 chr17:17741425 SREBF1 0.61 11.36 0.53 1.86e-25 Total body bone mineral density; CRC cis rs1865760 0.865 rs1115920 chr6:25954027 A/G cg17691542 chr6:26056736 HIST1H1C 0.55 8.26 0.41 3.65e-15 Height; CRC cis rs73206853 0.764 rs9737665 chr12:111031847 A/C cg12870014 chr12:110450643 ANKRD13A 0.75 9.11 0.45 7.96e-18 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC cis rs7091068 0.567 rs1572773 chr10:95432968 T/C cg20715218 chr10:95462985 C10orf4 0.56 7.57 0.39 3.81e-13 Urinary tract infection frequency; CRC cis rs6504950 0.800 rs9907961 chr17:53012927 C/G cg26251398 chr17:52985966 TOM1L1 0.37 5.62 0.3 4.04e-8 Breast cancer; CRC cis rs3617 0.573 rs9860296 chr3:52913781 A/G cg11645453 chr3:52864694 ITIH4 0.36 6.79 0.35 5.15e-11 Red blood cell count;Autism spectrum disorder or schizophrenia; CRC cis rs10256972 0.567 rs7782651 chr7:1159895 T/G cg03923535 chr7:1197113 ZFAND2A 0.68 9.71 0.47 9.02e-20 Longevity;Endometriosis; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg05350266 chr1:32687823 EIF3I;C1orf91 0.47 6.62 0.34 1.43e-10 Response to antipsychotic treatment; CRC cis rs473651 0.935 rs508483 chr2:239339709 T/C cg18131467 chr2:239335373 ASB1 1.01 22.41 0.78 3.47e-68 Multiple system atrophy; CRC cis rs4731207 0.565 rs10954053 chr7:124586815 A/G cg23710748 chr7:124431027 NA -0.38 -6.08 -0.32 3.35e-9 Cutaneous malignant melanoma; CRC cis rs10540 1.000 rs117339389 chr11:505025 T/A cg08200582 chr11:442649 ANO9 -0.68 -6.87 -0.35 3.26e-11 Body mass index; CRC cis rs853679 0.517 rs12174753 chr6:28042465 C/G cg12963246 chr6:28129442 ZNF389 0.48 5.75 0.3 2.05e-8 Depression; CRC cis rs798554 0.757 rs1182177 chr7:2874540 C/T cg04166393 chr7:2884313 GNA12 0.52 6.87 0.35 3.13e-11 Height; CRC cis rs10946940 0.965 rs62401383 chr6:27564547 C/T cg06470822 chr6:28175283 NA -0.5 -6.95 -0.36 1.96e-11 Systemic lupus erythematosus; CRC cis rs2243480 0.901 rs58207111 chr7:65486723 C/T cg25985355 chr7:65971099 NA -0.5 -5.73 -0.3 2.25e-8 Diabetic kidney disease; CRC cis rs2732480 0.538 rs1387259 chr12:48703522 C/T cg21466736 chr12:48725269 NA 0.59 8.76 0.44 1.02e-16 Hemoglobin concentration;Red blood cell count;Hematocrit; CRC cis rs1656402 1.000 rs1729253 chr2:233428740 G/C cg03852847 chr2:233439513 NA 0.44 7.56 0.38 4.08e-13 Non-small cell lung cancer (survival); CRC cis rs6735179 0.609 rs13405140 chr2:1759020 C/T cg19300414 chr2:1746591 PXDN 0.35 6.17 0.32 2.04e-9 Response to antipsychotic treatment; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg14385122 chr9:71320671 PIP5K1B 0.37 6.06 0.32 3.63e-9 Liver disease severity in Alagille syndrome; CRC cis rs6840360 0.554 rs10222838 chr4:152690099 T/C cg22705602 chr4:152727874 NA -0.35 -5.88 -0.31 9.94e-9 Intelligence (multi-trait analysis); CRC cis rs12024301 0.557 rs12042642 chr1:183614246 C/T cg11505048 chr1:183622726 RGL1;APOBEC4 -0.78 -6.79 -0.35 5.39e-11 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs11190604 1.000 rs2495752 chr10:102326115 T/C cg16342193 chr10:102329863 NA -0.36 -5.96 -0.31 6.6e-9 Palmitoleic acid (16:1n-7) levels; CRC cis rs6598955 0.671 rs17163746 chr1:26564230 C/A cg04990556 chr1:26633338 UBXN11 0.54 5.85 0.31 1.19e-8 Obesity-related traits; CRC trans rs1455244 0.700 rs7229302 chr18:11508904 G/T cg01368872 chr15:91498139 RCCD1 0.43 6.58 0.34 1.85e-10 Schizophrenia; CRC cis rs6570726 0.935 rs442254 chr6:145849118 T/C cg05347473 chr6:146136440 FBXO30 0.38 6.09 0.32 3.19e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs6570726 0.935 rs419854 chr6:145844085 A/C cg23711669 chr6:146136114 FBXO30 0.69 12.31 0.56 6.55e-29 Lobe attachment (rater-scored or self-reported); CRC cis rs10946940 0.896 rs12208078 chr6:27498581 G/A cg21251018 chr6:28226885 NKAPL -0.41 -6.33 -0.33 7.81e-10 Systemic lupus erythematosus; CRC cis rs10493773 0.609 rs11161664 chr1:86185379 C/T cg00734567 chr1:86172782 ZNHIT6 -0.48 -7.38 -0.38 1.35e-12 Urate levels in overweight individuals; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg05000123 chr14:20937394 PNP 0.43 6.16 0.32 2.09e-9 Response to antipsychotic treatment; CRC cis rs6570726 0.935 rs408768 chr6:145871735 A/G cg05347473 chr6:146136440 FBXO30 0.39 6.19 0.32 1.79e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs6951245 1.000 rs78185801 chr7:1096367 G/A cg03188948 chr7:1209495 NA 0.66 6.94 0.36 2.04e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs7666738 0.830 rs34164616 chr4:99015251 G/A cg17366294 chr4:99064904 C4orf37 0.44 7.35 0.38 1.55e-12 Colonoscopy-negative controls vs population controls; CRC cis rs4665809 0.941 rs1434079 chr2:26284670 C/G cg04944784 chr2:26401820 FAM59B -0.6 -7.7 -0.39 1.64e-13 Gut microbiome composition (summer); CRC cis rs17376456 0.877 rs12716456 chr5:93397557 A/G cg09848695 chr5:92956644 FAM172A;MIR2277 0.63 6.16 0.32 2.11e-9 Diabetic retinopathy; CRC cis rs13108904 0.846 rs3775100 chr4:1225106 T/C cg16405210 chr4:1374714 KIAA1530 -0.39 -5.63 -0.3 3.83e-8 Obesity-related traits; CRC trans rs7546 0.504 rs2075637 chr16:4938280 T/C cg19252218 chr17:41477271 ARL4D -0.44 -6.57 -0.34 1.98e-10 Cancer; CRC cis rs1005277 0.579 rs1621040 chr10:38497232 T/C cg25517755 chr10:38738941 LOC399744 -0.4 -5.88 -0.31 1.03e-8 Extrinsic epigenetic age acceleration; CRC trans rs7395662 0.571 rs4882020 chr11:48615658 C/T cg15704280 chr7:45808275 SEPT13 -0.49 -6.85 -0.35 3.64e-11 HDL cholesterol; CRC cis rs12580194 0.593 rs7485991 chr12:55789129 T/C cg19537932 chr12:55886519 OR6C68 -0.72 -9.22 -0.45 3.64e-18 Cancer; CRC cis rs11514810 1.000 rs11514810 chr7:1428476 C/T cg24899294 chr7:1481343 MICALL2 -0.62 -6.64 -0.34 1.27e-10 Executive inhibition (Stroop WIT and CIT) in attention deficit hyperactivity disorder; CRC cis rs9660180 0.967 rs6664664 chr1:1751264 G/A cg13866156 chr1:1669148 SLC35E2 -0.63 -9.83 -0.48 3.56e-20 Body mass index; CRC cis rs7107174 1.000 rs7107174 chr11:77997936 C/T cg02023728 chr11:77925099 USP35 0.53 7.64 0.39 2.37e-13 Testicular germ cell tumor; CRC cis rs1003719 0.612 rs2835652 chr21:38557408 G/T cg10648535 chr21:38446584 PIGP;TTC3 -0.48 -6.67 -0.35 1.06e-10 Eye color traits; CRC cis rs4731207 0.596 rs7779244 chr7:124652930 G/A cg23710748 chr7:124431027 NA -0.39 -6.24 -0.33 1.35e-9 Cutaneous malignant melanoma; CRC cis rs2251381 0.778 rs722013 chr21:30549245 G/T cg24692254 chr21:30365293 RNF160 0.76 12.33 0.56 5.58e-29 Selective IgA deficiency; CRC cis rs4919694 1.000 rs78214351 chr10:104822688 A/G cg04362960 chr10:104952993 NT5C2 1.09 10.36 0.5 5.71e-22 Arsenic metabolism; CRC cis rs7847628 0.551 rs10818476 chr9:123572038 A/G cg14255062 chr9:123606675 PSMD5;LOC253039 0.59 9.8 0.48 4.69e-20 Birth weight; CRC cis rs1577917 0.538 rs7755996 chr6:86423720 C/T cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A 0.42 5.7 0.3 2.72e-8 Response to antipsychotic treatment; CRC cis rs826838 0.616 rs11182893 chr12:38627715 C/G cg26384229 chr12:38710491 ALG10B -0.53 -7.72 -0.39 1.38e-13 Heart rate; CRC cis rs9925964 0.933 rs2303222 chr16:31085470 A/G cg03418659 chr16:31128414 MYST1 0.46 6.79 0.35 5.14e-11 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg15585372 chr7:97910571 BRI3 0.45 6.76 0.35 6.11e-11 Intelligence (multi-trait analysis); CRC trans rs6550704 0.687 rs9865314 chr3:22634337 A/G cg21215323 chr15:41220556 DLL4 -0.41 -6.15 -0.32 2.2e-9 Daytime sleep phenotypes; CRC cis rs4665809 0.590 rs35532350 chr2:26441605 T/C cg08067268 chr2:26466485 HADHB;HADHA -0.65 -8.34 -0.42 2e-15 Gut microbiome composition (summer); CRC cis rs7429990 1.000 rs7429990 chr3:47901803 C/A cg11946769 chr3:48343235 NME6 0.5 6.24 0.33 1.32e-9 Educational attainment (years of education); CRC cis rs59104589 0.535 rs73004374 chr2:242378000 T/C cg19488206 chr2:242435732 STK25 0.46 6.89 0.36 2.8e-11 Fibrinogen levels; CRC cis rs2286885 1.000 rs10819169 chr9:129249625 C/T cg15282417 chr9:129245246 FAM125B 0.47 8.68 0.43 1.85e-16 Intraocular pressure; CRC cis rs9487051 0.676 rs9374077 chr6:109600194 C/T cg12927641 chr6:109611667 NA -0.36 -6.32 -0.33 8.39e-10 Reticulocyte fraction of red cells; CRC cis rs703842 1.000 rs10877014 chr12:58167661 A/G cg00677455 chr12:58241039 CTDSP2 0.68 9.75 0.47 6.73e-20 Multiple sclerosis; CRC cis rs208520 0.690 rs1318604 chr6:66825278 A/C cg07460842 chr6:66804631 NA -1.09 -15.06 -0.64 2.3e-39 Exhaled nitric oxide output; CRC cis rs4654899 0.965 rs7512116 chr1:21501095 C/A cg02927042 chr1:21476669 EIF4G3 -0.48 -7.58 -0.39 3.62e-13 Superior frontal gyrus grey matter volume; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg23702657 chr12:49525491 TUBA1B 0.38 6.08 0.32 3.31e-9 Liver disease severity in Alagille syndrome; CRC cis rs7312933 1.000 rs11181328 chr12:42504679 T/G cg01256987 chr12:42539512 GXYLT1 -0.43 -6.6 -0.34 1.62e-10 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CRC cis rs425277 0.585 rs2222217 chr1:2063164 G/A cg19257562 chr1:2043853 PRKCZ 0.42 6.83 0.35 4.03e-11 Height; CRC cis rs6460942 0.841 rs6968277 chr7:12443795 C/A cg06484146 chr7:12443880 VWDE -0.74 -9.48 -0.46 5.22e-19 Coronary artery disease; CRC cis rs2204008 0.837 rs55962152 chr12:38234281 G/A cg13010199 chr12:38710504 ALG10B 0.45 5.82 0.31 1.39e-8 Bladder cancer; CRC cis rs2880765 0.835 rs6496027 chr15:86049988 C/T cg17133734 chr15:86042851 AKAP13 0.42 6.66 0.34 1.15e-10 Coronary artery disease; CRC cis rs17065868 0.764 rs61949763 chr13:45007475 T/C cg10246903 chr13:45222710 NA 0.56 6.21 0.32 1.64e-9 Antineutrophil cytoplasmic antibody-associated vasculitis; CRC cis rs11958404 0.932 rs72818109 chr5:157438340 A/T cg05962755 chr5:157440814 NA 1.01 12.88 0.58 5.12e-31 IgG glycosylation; CRC cis rs6502050 0.667 rs9892469 chr17:80093657 T/C cg25804541 chr17:80189381 SLC16A3 -0.3 -5.85 -0.31 1.19e-8 Life satisfaction; CRC cis rs780096 0.526 rs1260341 chr2:27663215 T/A cg12648201 chr2:27665141 KRTCAP3 -0.32 -6.36 -0.33 6.91e-10 Total body bone mineral density; CRC trans rs13221576 0.569 rs13247984 chr7:93989677 A/T cg25582398 chr5:1217743 SLC6A19 0.59 6.4 0.33 5.3e-10 Intelligence; CRC cis rs6500602 0.702 rs2058812 chr16:4524443 C/G cg08645402 chr16:4508243 NA 0.63 11.06 0.52 2.13e-24 Schizophrenia; CRC cis rs9398803 0.763 rs576049 chr6:126730543 T/G cg19875578 chr6:126661172 C6orf173 0.42 6.02 0.31 4.78e-9 Male-pattern baldness; CRC cis rs6960043 0.738 rs6461153 chr7:15059796 G/C cg19272540 chr7:15055459 NA -0.24 -6.43 -0.33 4.36e-10 Type 2 diabetes; CRC cis rs8005677 1.000 rs1951119 chr14:23388326 A/C cg01529538 chr14:23388837 RBM23 0.4 6.18 0.32 1.86e-9 Cognitive ability (multi-trait analysis); CRC cis rs10504229 0.775 rs55764517 chr8:58158238 G/A cg11062466 chr8:58055876 NA 0.45 6.01 0.31 4.87e-9 Developmental language disorder (linguistic errors); CRC cis rs4665809 0.589 rs4665841 chr2:26448950 G/A cg26119090 chr2:26468346 HADHA;HADHB -0.99 -14.52 -0.62 3.02e-37 Gut microbiome composition (summer); CRC cis rs7781266 0.501 rs10274077 chr7:133624271 C/T cg03336402 chr7:133662267 EXOC4 0.66 9.96 0.48 1.35e-20 Educational attainment (college completion); CRC cis rs3785574 0.962 rs2584633 chr17:61879501 T/C cg25654072 chr17:61904446 PSMC5;FTSJ3 0.43 6.06 0.32 3.71e-9 Height; CRC cis rs2070488 1.000 rs1841777 chr3:38484819 T/C cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.91 16.81 0.68 3.37e-46 Electrocardiographic conduction measures; CRC cis rs2439831 1.000 rs28628574 chr15:43802038 A/C cg15269541 chr15:43626905 ADAL -0.57 -6.29 -0.33 9.92e-10 Lung cancer in ever smokers; CRC cis rs2013441 0.932 rs3850782 chr17:20181940 A/C cg13482628 chr17:19912719 NA -0.4 -6.17 -0.32 2e-9 Obesity-related traits; CRC trans rs4658101 0.700 rs12048543 chr1:92050356 C/T cg17068236 chr19:2051260 MKNK2 0.46 6.19 0.32 1.76e-9 Optic disc area;Vertical cup-disc ratio; CRC cis rs1707322 0.721 rs4609469 chr1:46117185 C/T cg06784218 chr1:46089804 CCDC17 0.65 12.18 0.56 2.04e-28 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs1042058 0.565 rs650110 chr10:30753132 A/G cg18806716 chr10:30721971 MAP3K8 -0.58 -8.24 -0.41 4.26e-15 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; CRC cis rs2952156 0.959 rs1495102 chr17:37832093 T/C cg00129232 chr17:37814104 STARD3 -0.69 -11.62 -0.54 2.25e-26 Asthma; CRC cis rs4819052 0.724 rs9753987 chr21:46661389 C/T cg11663144 chr21:46675770 NA -0.83 -14.12 -0.61 9.88e-36 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC trans rs11098499 0.754 rs12510269 chr4:120241646 A/G cg25214090 chr10:38739885 LOC399744 0.53 8.36 0.42 1.78e-15 Corneal astigmatism; CRC cis rs9522267 0.535 rs4644738 chr13:112235995 G/A cg10483660 chr13:112241077 NA -0.48 -9.0 -0.44 1.85e-17 Hepatitis; CRC cis rs4073582 0.595 rs1115508 chr11:65923149 A/G cg16950941 chr11:66035639 RAB1B 0.69 12.1 0.55 4.1e-28 Gout; CRC cis rs4478858 0.735 rs1566961 chr1:31772450 G/A cg00250761 chr1:31883323 NA -0.43 -8.36 -0.42 1.84e-15 Alcohol dependence; CRC cis rs13256369 0.901 rs12679831 chr8:8566411 T/G cg06636001 chr8:8085503 FLJ10661 0.47 5.8 0.3 1.53e-8 Obesity-related traits; CRC cis rs11168351 0.864 rs12228750 chr12:48496997 G/A cg24011408 chr12:48396354 COL2A1 -0.43 -6.36 -0.33 6.93e-10 Bipolar disorder and schizophrenia; CRC cis rs1670533 0.932 rs13140341 chr4:1054235 T/C cg27284194 chr4:1044797 NA 0.5 6.18 0.32 1.91e-9 Recombination rate (females); CRC cis rs11212617 0.967 rs228589 chr11:108093208 A/T cg12106634 chr11:108092400 ATM;NPAT 0.43 6.37 0.33 6.28e-10 Response to metformin in type 2 diabetes (glycemic); CRC cis rs28386778 0.830 rs2665841 chr17:61861219 A/T cg23090583 chr17:61904693 PSMC5;FTSJ3 1.05 20.29 0.75 6.44e-60 Prudent dietary pattern; CRC cis rs6952808 0.771 rs10275045 chr7:1920826 C/T cg21782813 chr7:2030301 MAD1L1 0.39 7.06 0.36 9.72e-12 Bipolar disorder and schizophrenia; CRC cis rs17270561 0.609 rs1937127 chr6:25769872 G/T cg16482183 chr6:26056742 HIST1H1C -0.72 -9.17 -0.45 5.37e-18 Iron status biomarkers; CRC cis rs514406 0.929 rs564273 chr1:53332445 G/C cg24675658 chr1:53192096 ZYG11B -0.54 -8.11 -0.41 1.02e-14 Monocyte count; CRC cis rs4731207 0.698 rs12666427 chr7:124479352 A/G cg23710748 chr7:124431027 NA 0.38 6.08 0.32 3.42e-9 Cutaneous malignant melanoma; CRC cis rs12188164 0.965 rs72717438 chr5:448663 C/T cg21972741 chr5:435613 AHRR 0.54 7.37 0.38 1.39e-12 Cystic fibrosis severity; CRC cis rs6912958 0.781 rs2268993 chr6:88184111 G/A cg12350822 chr6:88032061 C6orf162;GJB7 -0.33 -6.23 -0.32 1.47e-9 Monocyte percentage of white cells; CRC cis rs2032447 0.714 rs175319 chr6:25956172 A/G cg17691542 chr6:26056736 HIST1H1C 0.42 5.77 0.3 1.78e-8 Intelligence (multi-trait analysis); CRC cis rs13191362 0.935 rs4273664 chr6:162955494 T/G cg21926612 chr6:163149169 PACRG;PARK2 0.82 10.25 0.49 1.38e-21 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs7487075 0.930 rs4076484 chr12:46833912 C/G cg22049899 chr12:47219821 SLC38A4 0.32 6.44 0.33 4.31e-10 Itch intensity from mosquito bite; CRC trans rs11148252 0.904 rs7990581 chr13:53019433 A/G cg18335740 chr13:41363409 SLC25A15 0.61 9.8 0.48 4.77e-20 Lewy body disease; CRC cis rs561341 1.000 rs508192 chr17:30315147 C/T cg12193833 chr17:30244370 NA 0.71 8.11 0.41 9.97e-15 Hip circumference adjusted for BMI; CRC cis rs4268898 0.552 rs11125454 chr2:24373669 T/C cg06627628 chr2:24431161 ITSN2 0.46 6.9 0.36 2.68e-11 Asthma; CRC cis rs4728302 0.869 rs958405 chr7:133597151 A/G cg10665199 chr7:133106180 EXOC4 0.38 5.77 0.3 1.81e-8 Intelligence;Intelligence (multi-trait analysis); CRC cis rs758324 0.853 rs6865911 chr5:131204659 A/G cg06307176 chr5:131281290 NA 0.43 6.35 0.33 7.21e-10 Alzheimer's disease in APOE e4- carriers; CRC cis rs8177253 0.665 rs9869257 chr3:133451412 G/T cg11941060 chr3:133502564 NA -0.47 -7.65 -0.39 2.28e-13 Iron status biomarkers; CRC cis rs6831352 0.734 rs1453872 chr4:100022482 G/A cg13256891 chr4:100009986 ADH5 0.57 7.92 0.4 3.62e-14 Alcohol dependence; CRC cis rs10857712 0.754 rs2297032 chr10:135234580 C/T cg19904058 chr10:135279010 LOC619207 -0.35 -6.78 -0.35 5.56e-11 Systemic lupus erythematosus; CRC trans rs10983614 1.000 rs7867776 chr9:120072627 A/G cg21937244 chr14:103406412 CDC42BPB -0.4 -6.04 -0.32 4.08e-9 Survival in pancreatic cancer; CRC cis rs10504229 0.683 rs17194529 chr8:58105647 A/G cg02290350 chr8:58132656 NA -0.58 -6.83 -0.35 4.22e-11 Developmental language disorder (linguistic errors); CRC cis rs2014572 0.967 rs11667407 chr19:57763122 C/T cg12963866 chr19:57752005 ZNF805 -0.41 -6.09 -0.32 3.15e-9 Hyperactive-impulsive symptoms; CRC cis rs7945705 0.869 rs7925728 chr11:9013002 A/G cg14711859 chr11:8959438 ASCL3 0.41 6.87 0.35 3.13e-11 Hemoglobin concentration; CRC cis rs798554 0.797 rs2107964 chr7:2863574 G/A cg17321639 chr7:2759063 NA -0.54 -7.11 -0.36 7.26e-12 Height; CRC cis rs6840360 0.550 rs4696289 chr4:152621237 C/T cg09659197 chr4:152720779 NA 0.32 5.71 0.3 2.48e-8 Intelligence (multi-trait analysis); CRC cis rs4664308 1.000 rs10929966 chr2:160908341 C/T cg03641300 chr2:160917029 PLA2R1 -0.75 -12.46 -0.57 1.81e-29 Idiopathic membranous nephropathy; CRC cis rs12220238 0.915 rs7922519 chr10:75976573 G/C cg19889307 chr10:75911429 ADK;AP3M1 0.54 5.61 0.3 4.26e-8 Soluble interleukin-2 receptor subunit alpha; CRC cis rs59918340 0.764 rs2304282 chr8:142229543 A/G cg17298326 chr8:142245477 NA -0.37 -5.66 -0.3 3.36e-8 Immature fraction of reticulocytes; CRC cis rs9486715 1.000 rs6905568 chr6:97066382 T/C cg18709589 chr6:96969512 KIAA0776 -0.47 -6.63 -0.34 1.35e-10 Headache; CRC cis rs9611565 0.649 rs5758466 chr22:42176059 G/A cg03806693 chr22:41940476 POLR3H 0.68 9.46 0.46 6.05e-19 Vitiligo; CRC cis rs4555082 0.957 rs2816629 chr14:105737261 G/A cg13114125 chr14:105738426 BRF1 -0.74 -11.26 -0.53 4.24e-25 Mean platelet volume;Platelet distribution width; CRC cis rs11146838 1 rs11146838 chr10:39149977 A/T cg25517755 chr10:38738941 LOC399744 -0.44 -6.43 -0.33 4.44e-10 Breast cancer; CRC cis rs427941 0.703 rs201455 chr7:101740212 C/T cg06246474 chr7:101738831 CUX1 0.45 7.18 0.37 4.77e-12 Plasma omega-3 polyunsaturated fatty acid level (eicosapentaenoic acid); CRC cis rs3824347 0.804 rs2146047 chr9:77649155 T/C cg01251476 chr9:77566080 C9orf40 0.37 5.74 0.3 2.13e-8 Urinary magnesium-to-creatinine ratio; CRC cis rs11190604 0.767 rs7916904 chr10:102186778 C/G cg07080220 chr10:102295463 HIF1AN 0.51 6.44 0.33 4.27e-10 Palmitoleic acid (16:1n-7) levels; CRC cis rs4862750 0.914 rs1991256 chr4:187875330 A/G cg11301795 chr4:187892539 NA -0.84 -18.62 -0.72 2.33e-53 Lobe attachment (rater-scored or self-reported); CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg11296937 chr11:64084966 PRDX5;TRMT112 0.39 6.03 0.32 4.39e-9 Obesity-related traits; CRC cis rs1552244 1.000 rs61077902 chr3:10126153 T/G cg16606324 chr3:10149918 C3orf24 0.73 10.1 0.49 4.59e-21 Alzheimer's disease; CRC trans rs629535 0.814 rs545720 chr8:70063370 T/C cg21567404 chr3:27674614 NA 0.93 15.32 0.65 2.21e-40 Dupuytren's disease; CRC cis rs924607 0.931 rs1709556 chr5:637058 A/G cg04221910 chr5:616842 CEP72 0.41 6.77 0.35 5.99e-11 Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia; CRC cis rs4566357 0.576 rs3769644 chr2:227917240 C/G cg11843606 chr2:227700838 RHBDD1 -0.44 -6.85 -0.35 3.65e-11 Coronary artery disease; CRC cis rs11098499 0.863 rs11098531 chr4:120465001 G/A cg09307838 chr4:120376055 NA 0.67 10.3 0.49 9.15e-22 Corneal astigmatism; CRC cis rs7264396 0.563 rs7268195 chr20:34339854 G/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.47 -6.34 -0.33 7.56e-10 Total cholesterol levels; CRC cis rs9811920 0.732 rs793446 chr3:99578114 A/T cg07805332 chr3:99536008 MIR548G;C3orf26 0.39 6.04 0.32 4.18e-9 Axial length; CRC cis rs2019137 0.967 rs895412 chr2:113973964 T/C cg21550016 chr2:113992930 PAX8;LOC440839;LOC654433 -0.52 -7.44 -0.38 9.02e-13 Lymphocyte counts; CRC cis rs796364 0.951 rs11675980 chr2:201051150 A/G cg23649088 chr2:200775458 C2orf69 -0.57 -6.01 -0.31 5.02e-9 Schizophrenia; CRC cis rs7666738 0.962 rs11728816 chr4:98951767 C/T cg05340658 chr4:99064831 C4orf37 0.51 7.22 0.37 3.71e-12 Colonoscopy-negative controls vs population controls; CRC cis rs2230307 0.536 rs56215716 chr1:100447486 G/A cg24955406 chr1:100503596 HIAT1 0.52 6.28 0.33 1.07e-9 Carotid intima media thickness; CRC cis rs10927875 0.864 rs1976402 chr1:16143779 G/A cg21385522 chr1:16154831 NA -0.91 -11.49 -0.54 6.3e-26 Dilated cardiomyopathy; CRC cis rs2243480 1.000 rs1638734 chr7:66097539 A/C cg18252515 chr7:66147081 NA -1.23 -14.41 -0.62 7.84e-37 Diabetic kidney disease; CRC trans rs208520 0.690 rs10455594 chr6:66737894 C/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 1.05 14.83 0.63 1.81e-38 Exhaled nitric oxide output; CRC trans rs4942242 0.763 rs7327129 chr13:44233014 T/C cg19169023 chr15:41853346 TYRO3 -0.63 -9.52 -0.46 3.87e-19 Response to tocilizumab in rheumatoid arthritis; CRC cis rs4927850 0.918 rs4361313 chr3:195752260 A/G cg01181863 chr3:195395398 SDHAP2 -0.57 -7.97 -0.4 2.67e-14 Pancreatic cancer; CRC cis rs57221529 0.766 rs72703042 chr5:579269 C/T cg14541582 chr5:601475 NA -0.37 -7.13 -0.37 6.35e-12 Lung disease severity in cystic fibrosis; CRC cis rs67311347 1.000 rs1123019 chr3:40488280 C/T cg24209194 chr3:40518798 ZNF619 0.42 6.03 0.32 4.34e-9 Renal cell carcinoma; CRC trans rs6703335 0.870 rs10803142 chr1:243598234 A/G cg20803232 chr8:42995089 HGSNAT 0.44 6.37 0.33 6.23e-10 Schizophrenia;Schizophrenia, schizoaffective disorder or bipolar disorder; CRC cis rs6921919 0.638 rs2108926 chr6:28308747 A/T cg21251018 chr6:28226885 NKAPL 0.49 7.71 0.39 1.55e-13 Autism spectrum disorder or schizophrenia; CRC cis rs6502050 0.835 rs9900128 chr17:80087920 A/T cg13198984 chr17:80129470 CCDC57 0.47 8.45 0.42 9.24e-16 Life satisfaction; CRC cis rs7811142 1.000 rs1000215 chr7:100004543 A/G cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.88 12.07 0.55 5.31e-28 Platelet count; CRC cis rs6691722 0.503 rs12086212 chr1:24708740 C/T cg02336364 chr1:24764700 NIPAL3 0.37 6.18 0.32 1.93e-9 Response to interferon beta in multiple sclerosis; CRC cis rs7215564 0.908 rs36077104 chr17:78661757 T/A cg09596252 chr17:78655493 RPTOR 0.57 6.12 0.32 2.59e-9 Myopia (pathological); CRC cis rs8060686 0.844 rs3785100 chr16:67997920 T/C cg08314208 chr16:67682810 RLTPR -0.69 -7.45 -0.38 8.48e-13 HDL cholesterol;Metabolic syndrome; CRC cis rs7215564 0.908 rs34199628 chr17:78661675 A/G cg09596252 chr17:78655493 RPTOR 0.56 6.16 0.32 2.11e-9 Myopia (pathological); CRC cis rs2842992 0.915 rs2758321 chr6:160071611 C/G cg11366901 chr6:160182831 ACAT2 0.85 11.34 0.53 2.23e-25 Age-related macular degeneration (geographic atrophy); CRC cis rs7202877 0.656 rs4887812 chr16:75310052 G/A cg03315344 chr16:75512273 CHST6 0.54 6.18 0.32 1.9e-9 Type 2 diabetes;Type 1 diabetes; CRC cis rs801193 0.569 rs4717315 chr7:66178325 C/T cg12463550 chr7:65579703 CRCP 0.46 6.19 0.32 1.82e-9 Aortic root size; CRC cis rs7772486 0.875 rs7739371 chr6:146424353 C/G cg23711669 chr6:146136114 FBXO30 0.65 11.35 0.53 2.12e-25 Lobe attachment (rater-scored or self-reported); CRC cis rs6502050 0.697 rs8078634 chr17:80126208 C/T cg13198984 chr17:80129470 CCDC57 0.48 8.27 0.41 3.28e-15 Life satisfaction; CRC cis rs62432291 0.681 rs7757530 chr6:159647929 G/A cg14500486 chr6:159655392 FNDC1 0.75 10.25 0.49 1.39e-21 Joint mobility (Beighton score); CRC cis rs4824093 0.544 rs73443957 chr22:50305515 T/C cg22709217 chr22:50311962 ALG12;CRELD2 -0.86 -8.44 -0.42 1.01e-15 Amyotrophic lateral sclerosis (sporadic); CRC cis rs616402 0.527 rs10779737 chr1:10580275 C/G cg17425144 chr1:10567563 PEX14 0.56 12.94 0.58 3.03e-31 Breast size; CRC trans rs6561151 0.681 rs2121037 chr13:44471317 C/T cg12856521 chr11:46389249 DGKZ 0.76 10.47 0.5 2.5e-22 Crohn's disease; CRC cis rs732072 0.826 rs11605773 chr11:65474090 T/C cg21033440 chr11:65409861 SIPA1 -0.74 -6.03 -0.32 4.35e-9 Inflammatory bowel disease; CRC cis rs34779708 0.931 rs7099593 chr10:35366878 A/C cg03585969 chr10:35415529 CREM 0.57 7.61 0.39 2.94e-13 Inflammatory bowel disease;Crohn's disease; CRC cis rs9311474 0.508 rs17052259 chr3:52593138 A/G cg18404041 chr3:52824283 ITIH1 -0.41 -8.71 -0.43 1.56e-16 Electroencephalogram traits; CRC trans rs7615952 0.534 rs1503072 chr3:125754691 C/T cg07211511 chr3:129823064 LOC729375 -0.77 -10.24 -0.49 1.47e-21 Blood pressure (smoking interaction); CRC cis rs780096 0.506 rs2303369 chr2:27715416 C/T cg17158414 chr2:27665306 KRTCAP3 -0.29 -6.18 -0.32 1.9e-9 Total body bone mineral density; CRC cis rs796364 1.000 rs4263095 chr2:200830137 A/C cg12253985 chr2:200820533 C2orf60;C2orf47 -0.58 -6.37 -0.33 6.29e-10 Schizophrenia; CRC cis rs10504073 0.647 rs4873312 chr8:49991145 A/G cg00325661 chr8:49890786 NA 0.51 9.05 0.45 1.25e-17 Blood metabolite ratios; CRC cis rs8031584 0.958 rs8034856 chr15:31240957 T/C cg08109568 chr15:31115862 NA -0.54 -8.68 -0.43 1.82e-16 Huntington's disease progression; CRC cis rs16852403 0.583 rs10798596 chr1:178082642 T/C cg00404053 chr1:178313656 RASAL2 0.63 8.03 0.4 1.79e-14 Childhood ear infection; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg23538765 chr19:34919100 UBA2 0.44 6.05 0.32 3.87e-9 Response to antipsychotic treatment; CRC cis rs10736390 1.000 rs10736390 chr1:55103945 A/G cg01517571 chr1:55089959 ACOT11;FAM151A -0.78 -12.96 -0.58 2.67e-31 Survival in pancreatic cancer; CRC cis rs7959452 0.605 rs12819406 chr12:69696400 G/T cg20891283 chr12:69753455 YEATS4 0.78 13.0 0.58 1.76e-31 Blood protein levels; CRC cis rs853679 0.517 rs6941992 chr6:28106141 T/C cg02631126 chr6:28058918 ZSCAN12L1 0.29 5.89 0.31 9.41e-9 Depression; CRC cis rs2732480 0.517 rs2634676 chr12:48738236 A/G cg24011408 chr12:48396354 COL2A1 0.47 6.36 0.33 6.59e-10 Hemoglobin concentration;Red blood cell count;Hematocrit; CRC trans rs2571521 0.887 rs9298879 chr9:26097224 A/C cg11095027 chr11:1297066 TOLLIP -0.46 -6.57 -0.34 1.95e-10 Pursuit maintenance gain in psychotic disorders; CRC cis rs887829 0.569 rs4663965 chr2:234650604 A/G cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.49 -7.91 -0.4 3.9e-14 Metabolic traits;Bilirubin levels;Cholelithiasis-related traits in sickle cell anemia;Metabolite levels;Total bilirubin levels in HIV-1 infection;Serum metabolite levels;Blood metabolite levels; CRC cis rs651907 0.557 rs11720745 chr3:101441690 G/A cg11279151 chr3:101281821 RG9MTD1 -0.54 -7.4 -0.38 1.12e-12 Colorectal cancer; CRC cis rs9547692 1.000 rs2147168 chr13:37467503 A/C cg01493522 chr13:37497338 NA -0.52 -7.16 -0.37 5.21e-12 Coronary artery disease; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg03516708 chr14:24024880 THTPA 0.45 6.4 0.33 5.4e-10 Intelligence (multi-trait analysis); CRC trans rs79243044 0.786 rs16932549 chr11:5560909 C/T cg13610392 chr14:70078973 KIAA0247 -0.44 -6.01 -0.31 5.06e-9 QRS duration in Tripanosoma cruzi seropositivity; CRC cis rs9640161 0.750 rs1983440 chr7:150023941 G/C cg12556325 chr7:150026731 C7orf29;LRRC61 -0.44 -6.44 -0.33 4.12e-10 Blood protein levels;Circulating chemerin levels; CRC cis rs362272 0.525 rs2471347 chr4:3044435 A/G cg22930642 chr4:2936657 C4orf10;MFSD10 0.42 6.03 0.32 4.43e-9 Serum sulfate level; CRC cis rs478304 0.593 rs9666878 chr11:65475816 A/C cg05805236 chr11:65401703 PCNXL3 0.37 6.05 0.32 3.99e-9 Acne (severe); CRC cis rs853679 0.517 rs1947863 chr6:28099344 G/A cg18032046 chr6:28092343 ZSCAN16 -0.52 -6.08 -0.32 3.3e-9 Depression; CRC cis rs875971 0.545 rs17138156 chr7:65714695 C/T cg05627663 chr7:65219948 SNORA22;CCT6P1 0.59 7.68 0.39 1.89e-13 Aortic root size; CRC cis rs6502050 0.871 rs8082577 chr17:80070581 T/C cg25804541 chr17:80189381 SLC16A3 0.32 6.01 0.31 4.86e-9 Life satisfaction; CRC cis rs6662572 0.703 rs4660890 chr1:46297452 G/C cg08644498 chr1:46502608 NA -0.44 -6.97 -0.36 1.74e-11 Blood protein levels; CRC trans rs7618501 0.699 rs1317154 chr3:49910084 T/C cg21659725 chr3:3221576 CRBN 0.67 10.6 0.5 8.62e-23 Intelligence (multi-trait analysis); CRC trans rs875971 0.660 rs2191268 chr7:66110224 C/T cg09474336 chr3:195163530 ACAP2 -0.39 -6.22 -0.32 1.52e-9 Aortic root size; CRC cis rs7666738 0.606 rs6839946 chr4:99076132 A/C cg05340658 chr4:99064831 C4orf37 0.5 7.31 0.37 2.01e-12 Colonoscopy-negative controls vs population controls; CRC cis rs1475911 0.708 rs56185023 chr21:43521538 T/C cg19766460 chr21:43528205 UMODL1;C21orf128 0.96 14.47 0.62 4.59e-37 IgG glycosylation; CRC cis rs10876993 0.890 rs812304 chr12:58074853 A/C cg15848620 chr12:58087721 OS9 -0.61 -8.35 -0.42 1.97e-15 Celiac disease or Rheumatoid arthritis; CRC cis rs10504229 1.000 rs67388517 chr8:58176617 C/A cg05313129 chr8:58192883 C8orf71 -0.47 -6.99 -0.36 1.49e-11 Developmental language disorder (linguistic errors); CRC cis rs7666738 0.830 rs10005120 chr4:99038200 A/G cg05340658 chr4:99064831 C4orf37 0.61 9.47 0.46 5.78e-19 Colonoscopy-negative controls vs population controls; CRC cis rs8078723 0.966 rs57065891 chr17:38168227 C/T cg17467752 chr17:38218738 THRA 0.73 12.02 0.55 8e-28 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); CRC cis rs9826463 0.757 rs73240309 chr3:142240223 A/G cg20824294 chr3:142316082 PLS1 0.4 6.69 0.35 9.6e-11 QRS duration in Tripanosoma cruzi seropositivity; CRC cis rs7618915 0.547 rs34610878 chr3:52759169 G/C cg18404041 chr3:52824283 ITIH1 -0.43 -8.71 -0.43 1.54e-16 Bipolar disorder; CRC cis rs11190604 1.000 rs2295774 chr10:102265847 A/C cg16342193 chr10:102329863 NA -0.4 -6.42 -0.33 4.83e-10 Palmitoleic acid (16:1n-7) levels; CRC cis rs55883249 0.957 rs62119431 chr2:9750461 G/A cg23886495 chr2:9695866 ADAM17 0.51 5.86 0.31 1.11e-8 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; CRC cis rs11971779 0.680 rs11768023 chr7:139054395 T/A cg07862535 chr7:139043722 LUC7L2 0.71 8.94 0.44 2.83e-17 Diisocyanate-induced asthma; CRC cis rs9399135 0.935 rs4273704 chr6:135297520 G/T cg24558204 chr6:135376177 HBS1L 0.5 7.82 0.4 7.14e-14 Red blood cell count; CRC cis rs735396 0.595 rs2258287 chr12:121454313 G/T cg25281562 chr12:121454272 C12orf43 0.44 6.15 0.32 2.26e-9 N-glycan levels; CRC cis rs3204270 0.714 rs7189 chr17:79668897 C/T cg18367735 chr17:79674897 NA 0.54 6.13 0.32 2.54e-9 Dental caries; CRC cis rs6141769 0.542 rs28536730 chr20:31301954 A/C cg13636640 chr20:31349939 DNMT3B -0.39 -5.98 -0.31 5.67e-9 Subjective well-being; CRC cis rs2290405 0.527 rs4690329 chr4:931385 T/A cg10113582 chr4:905918 GAK -0.39 -5.62 -0.3 4.18e-8 Systemic sclerosis; CRC cis rs1008375 0.931 rs2109519 chr4:17695453 A/G cg16339924 chr4:17578868 LAP3 0.49 6.57 0.34 1.97e-10 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs72781680 1.000 rs72798408 chr2:24181845 G/C cg08917208 chr2:24149416 ATAD2B 1.04 10.13 0.49 3.61e-21 Lymphocyte counts; CRC cis rs3008870 1.000 rs58680688 chr1:67443751 C/G cg08660285 chr1:67390436 MIER1;WDR78 -1.02 -14.64 -0.63 1.01e-37 Lymphocyte percentage of white cells; CRC cis rs8060686 0.641 rs28548264 chr16:68211321 A/G cg26727032 chr16:67993705 SLC12A4 -0.56 -7.5 -0.38 6e-13 HDL cholesterol;Metabolic syndrome; CRC cis rs28386778 0.897 rs2665832 chr17:61912261 C/T cg11494091 chr17:61959527 GH2 0.6 10.14 0.49 3.44e-21 Prudent dietary pattern; CRC cis rs9400271 0.632 rs949881 chr6:109586240 A/G cg01475377 chr6:109611718 NA -0.37 -6.34 -0.33 7.63e-10 Sum neutrophil eosinophil counts;Sum basophil neutrophil counts;White blood cell count;Neutrophil count;Myeloid white cell count;Granulocyte count; CRC trans rs360798 0.532 rs189671 chr2:62959308 T/A cg05376469 chr2:102649931 NA 0.38 6.01 0.31 4.85e-9 Coronary artery disease; CRC cis rs10197940 0.624 rs3771901 chr2:152432481 G/A cg19508488 chr2:152266495 RIF1 0.55 7.59 0.39 3.23e-13 Lung cancer; CRC cis rs2160860 0.929 rs10216901 chr8:39804593 C/T cg11363097 chr8:39792086 IDO2 -0.4 -6.74 -0.35 7.31e-11 Blood metabolite levels; CRC cis rs9527 0.590 rs2148200 chr10:104879847 C/A cg04362960 chr10:104952993 NT5C2 0.6 8.31 0.42 2.6e-15 Arsenic metabolism; CRC cis rs7769051 0.522 rs6569852 chr6:133108333 C/A cg07930552 chr6:133119739 C6orf192 0.66 5.82 0.31 1.39e-8 Type 2 diabetes nephropathy; CRC cis rs10071761 0.513 rs59830931 chr5:40363541 T/C cg09067459 chr5:40385259 NA -0.53 -7.11 -0.37 7.18e-12 Selective IgA deficiency; CRC cis rs875971 0.862 rs3926380 chr7:66080645 G/T cg18876405 chr7:65276391 NA -0.54 -8.57 -0.43 4.17e-16 Aortic root size; CRC cis rs6912958 0.559 rs395358 chr6:88057924 T/C cg12350822 chr6:88032061 C6orf162;GJB7 0.46 9.36 0.46 1.26e-18 Monocyte percentage of white cells; CRC cis rs763121 0.853 rs6519120 chr22:38991393 A/C cg06544989 chr22:39130855 UNC84B -0.44 -6.6 -0.34 1.69e-10 Menopause (age at onset); CRC cis rs981844 0.666 rs7691303 chr4:154684198 T/C cg10279832 chr4:154682576 RNF175 0.38 5.69 0.3 2.83e-8 Response to statins (LDL cholesterol change); CRC cis rs9914988 0.943 rs9902953 chr17:27139834 C/A cg16670446 chr17:27188758 MIR451;MIR144 0.53 8.33 0.42 2.19e-15 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs2976388 1.000 rs2976398 chr8:143764879 G/C cg20041105 chr8:143859282 LYNX1 -0.33 -5.77 -0.3 1.81e-8 Urinary tract infection frequency; CRC cis rs1757171 0.542 rs3818986 chr6:37484349 C/A cg01843034 chr6:37503916 NA -0.39 -7.02 -0.36 1.28e-11 Cognitive performance; CRC cis rs1865760 0.566 rs9295686 chr6:26081983 G/C cg18357526 chr6:26021779 HIST1H4A 0.43 6.09 0.32 3.08e-9 Height; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg14685339 chr14:77787351 POMT2;GSTZ1 0.5 6.52 0.34 2.6e-10 Thyroid stimulating hormone; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg03113121 chr19:46366686 FOXA3;SYMPK 0.48 6.74 0.35 6.96e-11 Response to antipsychotic treatment; CRC cis rs9311676 0.656 rs11708895 chr3:58403042 T/C cg06643156 chr3:58380774 PXK 0.4 5.91 0.31 8.55e-9 Systemic lupus erythematosus; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg19937698 chr13:60970319 TDRD3 0.45 6.19 0.32 1.78e-9 Response to antipsychotic treatment; CRC cis rs9648716 1.000 rs3789806 chr7:140449071 C/G cg10747023 chr7:140774559 NA 0.45 5.8 0.3 1.52e-8 Type 2 diabetes; CRC cis rs6502050 0.835 rs67149434 chr17:80128007 G/A cg09264619 chr17:80180166 NA -0.34 -5.76 -0.3 1.93e-8 Life satisfaction; CRC cis rs6921919 0.583 rs1591913 chr6:28351728 C/T cg21251018 chr6:28226885 NKAPL 0.39 5.95 0.31 6.81e-9 Autism spectrum disorder or schizophrenia; CRC cis rs4908768 0.501 rs6577492 chr1:8575064 C/A cg20416874 chr1:8611966 RERE -0.42 -5.93 -0.31 7.72e-9 Neuroticism (multi-trait analysis);Subjective well-being (multi-trait analysis); CRC cis rs6951245 1.000 rs884977 chr7:1066410 T/C cg18402987 chr7:1209562 NA 0.55 6.83 0.35 4.02e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs6062302 0.534 rs1556456 chr20:62216289 T/C cg06363034 chr20:62225388 GMEB2 -0.4 -6.17 -0.32 2.06e-9 Glioblastoma; CRC trans rs1814175 0.645 rs7115592 chr11:50013243 A/G cg03929089 chr4:120376271 NA -0.88 -15.84 -0.66 2.09e-42 Height; CRC cis rs977987 0.843 rs28655617 chr16:75489642 G/A cg03315344 chr16:75512273 CHST6 0.53 9.02 0.45 1.65e-17 Dupuytren's disease; CRC cis rs853679 0.517 rs6941992 chr6:28106141 T/C cg12963246 chr6:28129442 ZNF389 0.49 5.78 0.3 1.73e-8 Depression; CRC cis rs13256369 0.802 rs11249884 chr8:8561552 C/T cg06636001 chr8:8085503 FLJ10661 -0.47 -5.94 -0.31 7.19e-9 Obesity-related traits; CRC cis rs11577318 0.853 rs12743998 chr1:26629882 G/A cg00852783 chr1:26633632 UBXN11 0.47 6.76 0.35 6.21e-11 Granulocyte percentage of myeloid white cells; CRC cis rs9892942 1 rs9892942 chr17:27178761 C/T cg20469991 chr17:27169893 C17orf63 -0.5 -5.94 -0.31 7.09e-9 Mean corpuscular volume;Mean corpuscular hemoglobin; CRC cis rs6912958 0.559 rs499373 chr6:88042062 A/T cg04972856 chr6:88032051 C6orf162;GJB7 0.35 6.5 0.34 2.92e-10 Monocyte percentage of white cells; CRC cis rs34779708 0.733 rs4298846 chr10:35547380 A/G cg03585969 chr10:35415529 CREM 0.52 6.79 0.35 5.37e-11 Inflammatory bowel disease;Crohn's disease; CRC cis rs10751667 0.857 rs7481221 chr11:966813 G/C cg01483505 chr11:975446 AP2A2 0.46 7.66 0.39 2.11e-13 Alzheimer's disease (late onset); CRC cis rs13108904 0.870 rs13124876 chr4:1247955 T/C cg20887711 chr4:1340912 KIAA1530 0.41 5.9 0.31 9.05e-9 Obesity-related traits; CRC cis rs875971 0.830 rs427575 chr7:65519219 A/G cg18876405 chr7:65276391 NA 0.53 8.99 0.44 2.05e-17 Aortic root size; CRC cis rs62244186 1.000 rs62244186 chr3:44739783 G/A cg10263370 chr3:44754102 ZNF502 -0.41 -6.78 -0.35 5.59e-11 Depressive symptoms; CRC cis rs932287 0.858 rs7109896 chr11:9054522 A/G cg12365402 chr11:9010492 NRIP3 0.39 6.3 0.33 9.69e-10 Colonoscopy-negative controls vs population controls; CRC cis rs7804356 0.954 rs3801808 chr7:26896555 T/A cg03456212 chr7:26904342 SKAP2 -0.5 -5.69 -0.3 2.77e-8 Type 1 diabetes; CRC cis rs59104589 0.617 rs16843642 chr2:242351379 T/G cg19488206 chr2:242435732 STK25 0.48 6.91 0.36 2.56e-11 Fibrinogen levels; CRC cis rs2739330 0.791 rs4822458 chr22:24265659 C/T cg10819733 chr22:24237672 NA -0.37 -6.39 -0.33 5.69e-10 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs6964587 1.000 rs6969981 chr7:91689461 G/C cg17063962 chr7:91808500 NA 0.8 14.02 0.61 2.36e-35 Breast cancer; CRC cis rs7552404 0.731 rs10732723 chr1:76392437 C/T cg10523679 chr1:76189770 ACADM -0.67 -8.49 -0.42 7.45e-16 Blood metabolite levels;Acylcarnitine levels; CRC cis rs2732480 0.538 rs1387259 chr12:48703522 C/T cg24011408 chr12:48396354 COL2A1 -0.45 -6.12 -0.32 2.65e-9 Hemoglobin concentration;Red blood cell count;Hematocrit; CRC cis rs17641971 0.684 rs7835336 chr8:49957895 A/G cg00325661 chr8:49890786 NA 0.35 5.98 0.31 5.95e-9 Blood metabolite levels; CRC trans rs7267979 0.740 rs2259961 chr20:25282626 T/G cg17903999 chr18:56338584 MALT1 -0.43 -6.91 -0.36 2.48e-11 Liver enzyme levels (alkaline phosphatase); CRC cis rs6502050 0.799 rs4789667 chr17:80162143 C/T cg22110888 chr17:80059540 CCDC57 0.41 6.44 0.33 4.15e-10 Life satisfaction; CRC cis rs17270561 0.723 rs12192635 chr6:25880907 A/T cg16482183 chr6:26056742 HIST1H1C 0.84 11.02 0.52 3.13e-24 Iron status biomarkers; CRC trans rs7726839 0.540 rs72703080 chr5:595238 A/G cg11887960 chr12:57824829 NA 0.58 6.43 0.33 4.44e-10 Obesity-related traits; CRC cis rs7927771 0.832 rs55677087 chr11:47397714 C/G cg20307385 chr11:47447363 PSMC3 -0.64 -9.39 -0.46 1.06e-18 Subjective well-being; CRC cis rs4888262 0.526 rs7201105 chr16:74590603 A/G cg01733217 chr16:74700730 RFWD3 0.74 11.15 0.52 1.08e-24 Testicular germ cell tumor; CRC cis rs6502050 0.835 rs8071425 chr17:80117335 C/T cg11859384 chr17:80120422 CCDC57 0.37 5.9 0.31 8.84e-9 Life satisfaction; CRC cis rs1448094 0.791 rs10863124 chr12:86352548 A/T cg19622623 chr12:86230825 RASSF9 -0.36 -5.66 -0.3 3.28e-8 Major depressive disorder; CRC cis rs172166 0.694 rs203884 chr6:28077374 G/T cg12172441 chr6:28176163 NA 0.52 7.22 0.37 3.63e-12 Cardiac Troponin-T levels; CRC cis rs6951245 1.000 rs2363286 chr7:1091625 A/G cg18402987 chr7:1209562 NA 0.62 6.83 0.35 4.21e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs6502050 0.835 rs7218857 chr17:80161000 T/C cg13198984 chr17:80129470 CCDC57 0.45 8.01 0.4 1.99e-14 Life satisfaction; CRC cis rs708547 0.647 rs2293175 chr4:57861358 C/T cg25525207 chr4:57843836 C4orf14;POLR2B -0.48 -6.92 -0.36 2.41e-11 Response to bleomycin (chromatid breaks); CRC cis rs16975963 0.644 rs11083427 chr19:38074152 G/T cg15135657 chr19:38346511 NA -0.46 -6.25 -0.33 1.31e-9 Longevity; CRC cis rs909674 0.524 rs5750821 chr22:39825492 A/T cg25956985 chr22:39795188 MAP3K7IP1 -0.45 -6.63 -0.34 1.35e-10 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; CRC cis rs9292777 0.897 rs6890268 chr5:40406050 A/T cg09067459 chr5:40385259 NA 0.52 9.13 0.45 7.13e-18 Crohn's disease;Multiple sclerosis; CRC cis rs17155006 0.530 rs408867 chr7:107743244 C/T cg05962710 chr7:107745446 LAMB4 -0.39 -6.92 -0.36 2.31e-11 Pneumococcal bacteremia; CRC cis rs561341 1.000 rs561341 chr17:30316385 T/G cg12193833 chr17:30244370 NA -0.75 -8.8 -0.44 7.92e-17 Hip circumference adjusted for BMI; CRC trans rs6561151 0.681 rs7995955 chr13:44434836 C/G cg12856521 chr11:46389249 DGKZ 0.73 10.56 0.5 1.21e-22 Crohn's disease; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg14163827 chr9:134270147 NA 0.38 6.02 0.31 4.72e-9 Response to antipsychotic treatment; CRC cis rs1552244 0.882 rs55808392 chr3:10054681 C/T cg08888203 chr3:10149979 C3orf24 0.63 8.2 0.41 5.64e-15 Alzheimer's disease; CRC cis rs896854 0.812 rs12546365 chr8:95911477 T/C cg09323728 chr8:95962352 TP53INP1 -0.4 -6.38 -0.33 5.84e-10 Type 2 diabetes; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg24437943 chr3:132136776 DNAJC13 0.47 6.51 0.34 2.79e-10 Response to antipsychotic treatment; CRC cis rs4972806 0.814 rs4246626 chr2:177046430 A/C cg10305451 chr2:177043427 NA 0.72 11.53 0.54 4.59e-26 IgG glycosylation; CRC cis rs13256369 0.951 rs13270852 chr8:8566853 A/G cg00074818 chr8:8560427 CLDN23 0.4 7.07 0.36 9.51e-12 Obesity-related traits; CRC cis rs7705042 0.865 rs2338821 chr5:141509433 A/G cg07392085 chr5:141489673 NDFIP1 0.46 7.24 0.37 3.17e-12 Asthma; CRC cis rs4819052 0.851 rs13047598 chr21:46660777 G/T cg19498844 chr21:46707878 POFUT2;LOC642852 0.77 10.99 0.52 3.97e-24 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs7208859 0.623 rs9894709 chr17:29078454 G/A cg13385521 chr17:29058706 SUZ12P 0.72 8.24 0.41 4.19e-15 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs2842992 0.872 rs2758315 chr6:160158640 T/C cg16489826 chr6:160211363 TCP1;MRPL18 0.47 5.96 0.31 6.39e-9 Age-related macular degeneration (geographic atrophy); CRC trans rs2303319 0.504 rs62189051 chr2:162622318 G/A cg03774468 chr3:140950104 ACPL2 -0.65 -6.07 -0.32 3.46e-9 Cognitive function; CRC cis rs9309473 0.607 rs6720094 chr2:73588076 A/G cg20560298 chr2:73613845 ALMS1 -0.5 -6.75 -0.35 6.89e-11 Metabolite levels; CRC cis rs12908161 0.959 rs12906348 chr15:85329421 A/C cg11189052 chr15:85197271 WDR73 0.6 8.55 0.43 4.6e-16 Schizophrenia; CRC cis rs2303759 0.709 rs2278405 chr19:49812403 A/C cg22307029 chr19:49891270 CCDC155 -0.68 -8.91 -0.44 3.43e-17 Multiple sclerosis; CRC trans rs61931739 0.517 rs11053063 chr12:34181011 C/T cg26384229 chr12:38710491 ALG10B 0.54 6.88 0.35 2.99e-11 Morning vs. evening chronotype; CRC cis rs10242455 0.702 rs73711293 chr7:99081595 C/T cg18809830 chr7:99032528 PTCD1 -1.3 -8.98 -0.44 2.15e-17 Blood metabolite levels; CRC cis rs4243830 0.571 rs60256927 chr1:6614747 G/A cg05709478 chr1:6581295 PLEKHG5 0.68 7.76 0.39 1.05e-13 Body mass index; CRC cis rs7914558 0.933 rs10883814 chr10:104737404 T/C cg15744005 chr10:104629667 AS3MT -0.35 -7.48 -0.38 7e-13 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs9372498 0.536 rs28605789 chr6:118889952 G/A cg10217327 chr6:118973057 C6orf204 0.52 5.87 0.31 1.08e-8 Diastolic blood pressure; CRC cis rs6088813 1.000 rs2425066 chr20:33927006 A/C cg14752227 chr20:34000481 UQCC 0.37 5.69 0.3 2.76e-8 Height; CRC cis rs736408 0.716 rs2239550 chr3:52822509 G/C cg08222913 chr3:52553049 STAB1 -0.33 -5.91 -0.31 8.53e-9 Bipolar disorder; CRC cis rs514406 0.861 rs35581164 chr1:53271373 C/G cg24675658 chr1:53192096 ZYG11B -0.58 -8.39 -0.42 1.46e-15 Monocyte count; CRC trans rs1814175 0.781 rs28681334 chr11:50051177 C/T cg11707556 chr5:10655725 ANKRD33B -0.42 -8.03 -0.4 1.75e-14 Height; CRC cis rs1223397 0.702 rs13191897 chr6:13288428 G/A cg07912922 chr6:13274314 PHACTR1 0.54 6.48 0.34 3.33e-10 Blood pressure; CRC trans rs58688157 0.639 rs60568231 chr11:575553 A/T cg19188899 chr13:112838565 NA -0.42 -6.45 -0.34 3.88e-10 Systemic lupus erythematosus; CRC cis rs9303401 0.614 rs62084387 chr17:57148027 C/T cg10487724 chr17:56770010 TEX14;RAD51C 0.76 8.36 0.42 1.79e-15 Cognitive test performance; CRC trans rs1656966 1.000 rs1656966 chr3:186466252 C/T cg26125625 chr3:124860871 SLC12A8 0.2 6.04 0.32 4.23e-9 Myopia (pathological); CRC cis rs8044868 0.586 rs6499564 chr16:72189655 G/A cg23815491 chr16:72088622 HP 0.41 5.99 0.31 5.53e-9 Body mass index (change over time) in cancer or chronic obstructive pulmonary disease;Body mass index (change over time) in cancer; CRC cis rs9807841 0.500 rs1368459 chr19:10835338 C/G cg17710535 chr19:10819994 QTRT1 0.48 7.57 0.39 3.78e-13 Inflammatory skin disease; CRC cis rs13191362 1.000 rs36042757 chr6:163004744 A/C cg21926612 chr6:163149169 PACRG;PARK2 0.76 11.15 0.52 1.03e-24 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs2295359 0.892 rs2064689 chr1:67653010 G/A cg03340356 chr1:67600835 NA 0.29 6.5 0.34 2.99e-10 Psoriasis; CRC trans rs2055729 0.677 rs1962430 chr8:9759620 G/T cg06636001 chr8:8085503 FLJ10661 0.57 7.02 0.36 1.31e-11 Multiple myeloma (hyperdiploidy); CRC cis rs3091242 0.933 rs61775174 chr1:25787313 G/A cg23205692 chr1:25664452 TMEM50A -0.42 -5.77 -0.3 1.82e-8 Erythrocyte sedimentation rate; CRC cis rs861020 0.630 rs592694 chr1:210009533 G/T cg05527609 chr1:210001259 C1orf107 0.8 11.17 0.52 8.64e-25 Orofacial clefts; CRC cis rs1799949 0.930 rs66499067 chr17:41248484 G/C cg23758822 chr17:41437982 NA 0.81 13.38 0.59 6.69e-33 Menopause (age at onset); CRC cis rs11650494 0.908 rs73324323 chr17:47420054 G/T cg08112188 chr17:47440006 ZNF652 1.19 11.24 0.53 5e-25 Prostate cancer; CRC cis rs17780086 0.527 rs72827711 chr17:30537920 T/A cg12193833 chr17:30244370 NA -0.71 -7.23 -0.37 3.45e-12 Height; CRC cis rs936229 0.768 rs936226 chr15:75069282 C/T cg10253484 chr15:75165896 SCAMP2 -0.4 -5.7 -0.3 2.64e-8 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); CRC cis rs12477438 0.520 rs7605843 chr2:99811894 C/T cg26064155 chr2:99771622 LIPT1;TSGA10 0.81 14.23 0.62 3.87e-36 Chronic sinus infection; CRC cis rs11645898 0.622 rs4788463 chr16:72223716 G/T cg14768367 chr16:72042858 DHODH -0.61 -6.91 -0.36 2.5e-11 Blood protein levels; CRC cis rs853679 0.517 rs9380065 chr6:28144751 A/G cg21251018 chr6:28226885 NKAPL 0.47 6.04 0.32 4.16e-9 Depression; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg06019692 chr13:20207818 MPHOSPH8 0.39 6.0 0.31 5.13e-9 Intelligence (multi-trait analysis); CRC cis rs992157 0.866 rs2292554 chr2:219146868 T/C cg00012203 chr2:219082015 ARPC2 -0.47 -7.05 -0.36 1.04e-11 Colorectal cancer; CRC cis rs4728142 0.604 rs7783384 chr7:128681297 T/C cg06630958 chr7:128577819 IRF5 -0.35 -5.68 -0.3 3.04e-8 Inflammatory bowel disease;Systemic lupus erythematosus;Ulcerative colitis; CRC cis rs4363385 0.747 rs1577964 chr1:152961784 C/A cg25856811 chr1:152973957 SPRR3 -0.28 -7.64 -0.39 2.38e-13 Inflammatory skin disease; CRC cis rs2816062 0.747 rs2816049 chr1:18893768 A/G cg18795169 chr1:18902165 NA -0.92 -19.27 -0.73 6.24e-56 Urate levels in lean individuals; CRC cis rs6504340 0.793 rs56128659 chr17:46621828 T/A cg04904318 chr17:46607828 HOXB1 -0.52 -6.0 -0.31 5.08e-9 Primary tooth development (number of teeth); CRC cis rs4629180 0.920 rs4851458 chr2:102108794 T/C cg04415270 chr2:102091202 RFX8 -0.57 -7.94 -0.4 3.2e-14 Chronic rhinosinusitis with nasal polyps; CRC cis rs897984 0.609 rs55979739 chr16:31049155 A/G cg00531865 chr16:30841666 NA -0.42 -5.98 -0.31 5.87e-9 Dementia with Lewy bodies; CRC cis rs17767392 1.000 rs35122644 chr14:71780768 C/T cg13720639 chr14:72061746 SIPA1L1 -0.54 -6.9 -0.36 2.71e-11 Mitral valve prolapse; CRC trans rs6076960 0.684 rs3909086 chr20:6251639 A/G cg21095983 chr6:86352623 SYNCRIP 0.53 7.44 0.38 9.13e-13 Smooth-surface caries; CRC cis rs67340775 0.541 rs200964 chr6:27866943 G/C cg19041857 chr6:27730383 NA -0.6 -6.51 -0.34 2.88e-10 Lung cancer in ever smokers; CRC cis rs8072100 0.967 rs4580230 chr17:45738861 G/A cg08085267 chr17:45401833 C17orf57 -0.66 -10.69 -0.51 4.15e-23 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs2204008 0.627 rs11176531 chr12:38152166 T/G cg13010199 chr12:38710504 ALG10B 0.52 6.46 0.34 3.77e-10 Bladder cancer; CRC cis rs10751667 0.666 rs7943140 chr11:973824 T/C cg01483505 chr11:975446 AP2A2 0.46 7.59 0.39 3.23e-13 Alzheimer's disease (late onset); CRC trans rs10982213 0.830 rs2274163 chr9:117188714 C/T cg19857114 chr3:176741225 TBL1XR1 -0.39 -6.18 -0.32 1.92e-9 Interleukin-6 levels; CRC cis rs877282 0.945 rs35342920 chr10:790484 T/C cg17470449 chr10:769945 NA 0.68 9.03 0.45 1.48e-17 Uric acid levels; CRC cis rs4268898 0.610 rs55860688 chr2:24451534 T/C cg06627628 chr2:24431161 ITSN2 -0.84 -11.42 -0.53 1.1e-25 Asthma; CRC cis rs28386778 0.863 rs894414 chr17:61916384 T/C cg07362569 chr17:61921086 SMARCD2 0.38 5.83 0.31 1.3e-8 Prudent dietary pattern; CRC cis rs1552244 0.554 rs34883592 chr3:10046165 C/T cg02579736 chr3:10068473 FANCD2;CIDECP 0.66 9.24 0.45 3.11e-18 Alzheimer's disease; CRC cis rs2444240 1.000 rs573211 chr11:120044762 G/A cg16005559 chr11:120040616 NA -0.36 -5.64 -0.3 3.7e-8 Corneal curvature; CRC trans rs6034559 0.521 rs6111223 chr20:16629479 A/C cg04525892 chr12:65822627 MSRB3 0.39 6.13 0.32 2.57e-9 Obsessive-compulsive disorder or autism spectrum disorder; CRC cis rs116095464 0.558 rs12173244 chr5:269524 G/A cg22496380 chr5:211416 CCDC127 -0.91 -10.56 -0.5 1.22e-22 Breast cancer; CRC cis rs28386778 0.901 rs2854194 chr17:61952110 T/G cg06601766 chr17:61851465 DDX42;CCDC47 0.46 6.21 0.32 1.58e-9 Prudent dietary pattern; CRC cis rs12594515 1.000 rs12906442 chr15:45985254 C/A cg01629716 chr15:45996671 NA 0.41 8.45 0.42 9.26e-16 Waist circumference;Weight; CRC cis rs1348850 0.558 rs4337505 chr2:178529714 A/T cg22681709 chr2:178499509 PDE11A -0.41 -7.58 -0.39 3.52e-13 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs1552244 0.515 rs7613004 chr3:9999913 A/C cg13047869 chr3:10149882 C3orf24 0.36 5.73 0.3 2.27e-8 Alzheimer's disease; CRC cis rs1707322 1.000 rs11211228 chr1:46399840 G/A cg03146154 chr1:46216737 IPP 0.51 7.09 0.36 8.17e-12 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs763121 0.819 rs5757160 chr22:38989646 T/C cg06544989 chr22:39130855 UNC84B 0.46 7.3 0.37 2.14e-12 Menopause (age at onset); CRC cis rs16975963 0.793 rs1807157 chr19:38465523 G/T cg15135657 chr19:38346511 NA -0.44 -5.8 -0.3 1.52e-8 Longevity; CRC cis rs2762353 0.574 rs34067542 chr6:25728210 T/A cg03264133 chr6:25882463 NA 0.73 10.28 0.49 1.13e-21 Blood metabolite levels; CRC trans rs2797160 1.000 rs1578794 chr6:126015469 T/C cg05039488 chr6:79577232 IRAK1BP1 0.51 7.59 0.39 3.37e-13 Endometrial cancer; CRC cis rs1801251 1.000 rs283476 chr2:233650168 A/G cg25237894 chr2:233734115 C2orf82 0.51 8.46 0.42 8.66e-16 Coronary artery disease; CRC cis rs6502050 0.731 rs35156322 chr17:80096323 T/C cg25804541 chr17:80189381 SLC16A3 -0.31 -5.97 -0.31 6.08e-9 Life satisfaction; CRC cis rs9733 0.596 rs56058687 chr1:150635066 C/T cg10589385 chr1:150898437 SETDB1 0.28 5.98 0.31 5.86e-9 Tonsillectomy; CRC trans rs10411161 1.000 rs8108583 chr19:52364977 C/A cg22319618 chr22:45562946 NUP50 -0.52 -6.03 -0.32 4.4e-9 Breast cancer; CRC cis rs2842992 0.830 rs2758313 chr6:160154099 C/G cg16489826 chr6:160211363 TCP1;MRPL18 0.49 6.13 0.32 2.51e-9 Age-related macular degeneration (geographic atrophy); CRC cis rs1552244 1.000 rs7628448 chr3:10146828 G/A cg16606324 chr3:10149918 C3orf24 0.71 9.17 0.45 5.16e-18 Alzheimer's disease; CRC cis rs2832191 0.755 rs2832193 chr21:30493589 T/C cg24692254 chr21:30365293 RNF160 -0.69 -11.81 -0.55 4.65e-27 Dental caries; CRC cis rs9818758 0.505 rs11716159 chr3:49631585 G/A cg01304814 chr3:48885189 PRKAR2A 0.8 6.1 0.32 2.93e-9 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; CRC cis rs9527 0.590 rs943039 chr10:104825132 C/T cg15744005 chr10:104629667 AS3MT -0.3 -5.96 -0.31 6.54e-9 Arsenic metabolism; CRC cis rs172166 0.611 rs203883 chr6:28078356 A/G cg06470822 chr6:28175283 NA 0.81 11.77 0.54 6.35e-27 Cardiac Troponin-T levels; CRC cis rs3820068 0.603 rs7537618 chr1:15977682 G/A cg27534772 chr1:16042836 PLEKHM2 0.55 10.69 0.51 4.19e-23 Systolic blood pressure; CRC cis rs881375 0.678 rs10985102 chr9:123707497 G/A cg09419670 chr9:123605666 PSMD5;LOC253039 0.49 7.88 0.4 4.83e-14 Rheumatoid arthritis; CRC cis rs7626444 0.625 rs1357287 chr3:196484967 A/G cg12930392 chr3:196481615 PAK2 0.38 6.83 0.35 4.16e-11 Monocyte count; CRC cis rs7618915 0.547 rs10780035 chr3:52764624 C/T cg05573699 chr3:52720067 GNL3;PBRM1 -0.44 -6.15 -0.32 2.23e-9 Bipolar disorder; CRC cis rs9443645 0.901 rs9443638 chr6:79720867 T/A cg05283184 chr6:79620031 NA -0.61 -9.64 -0.47 1.54e-19 Intelligence (multi-trait analysis); CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg11343086 chr1:202113710 ARL8A 0.48 6.27 0.33 1.16e-9 Thyroid stimulating hormone; CRC cis rs9443645 0.901 rs2174743 chr6:79591805 G/A cg11833968 chr6:79620685 NA -0.37 -6.47 -0.34 3.52e-10 Intelligence (multi-trait analysis); CRC cis rs10504229 0.728 rs17804624 chr8:58154216 T/C cg02725872 chr8:58115012 NA -0.57 -9.07 -0.45 1.09e-17 Developmental language disorder (linguistic errors); CRC cis rs6693567 0.545 rs2275246 chr1:150460168 A/G cg04165759 chr1:150448943 RPRD2 0.35 5.79 0.3 1.66e-8 Migraine; CRC cis rs9462027 0.651 rs2395599 chr6:34641415 G/C cg07306190 chr6:34760872 UHRF1BP1 -0.35 -6.32 -0.33 8.42e-10 Systemic lupus erythematosus; CRC trans rs3960554 0.808 rs60481386 chr7:75700962 A/G cg19862616 chr7:65841803 NCRNA00174 0.65 7.91 0.4 3.86e-14 Eotaxin levels; CRC cis rs875971 0.964 rs2161065 chr7:65932905 A/G cg18912574 chr7:65842487 NCRNA00174 0.36 6.1 0.32 2.97e-9 Aortic root size; CRC cis rs67340775 0.541 rs200974 chr6:27855845 A/G cg25164649 chr6:28176230 NA 0.59 6.01 0.31 5.06e-9 Lung cancer in ever smokers; CRC cis rs7618915 0.501 rs34157897 chr3:52716937 T/C cg11645453 chr3:52864694 ITIH4 0.36 6.51 0.34 2.74e-10 Bipolar disorder; CRC cis rs6761276 0.635 rs4145013 chr2:113830688 C/T cg24553058 chr2:113831203 IL1F10 0.38 5.71 0.3 2.56e-8 Protein quantitative trait loci; CRC cis rs78456975 1.000 rs55761535 chr2:1561450 A/G cg12573674 chr2:1569213 NA -0.74 -7.76 -0.39 1.09e-13 Placebo response in major depressive disorder (% change in symptom score); CRC cis rs597539 0.652 rs513615 chr11:68705504 G/T cg21963583 chr11:68658836 MRPL21 0.6 10.56 0.5 1.26e-22 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs34172651 0.606 rs7194189 chr16:24703484 G/T cg00339695 chr16:24857497 SLC5A11 -0.33 -6.63 -0.34 1.41e-10 Intelligence (multi-trait analysis); CRC cis rs6570726 0.791 rs408443 chr6:145874643 T/C cg23711669 chr6:146136114 FBXO30 0.77 13.41 0.59 5.06e-33 Lobe attachment (rater-scored or self-reported); CRC cis rs73200209 0.744 rs74349961 chr12:116467560 T/C cg01776926 chr12:116560359 MED13L -0.64 -7.6 -0.39 3.11e-13 Total body bone mineral density; CRC cis rs4363385 0.747 rs3806219 chr1:152972522 C/T cg25856811 chr1:152973957 SPRR3 0.25 7.05 0.36 1.04e-11 Inflammatory skin disease; CRC cis rs6840360 1.000 rs10023298 chr4:152666768 A/C cg09659197 chr4:152720779 NA 0.51 11.22 0.53 6.03e-25 Intelligence (multi-trait analysis); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg08679808 chr17:79886116 LOC92659;MAFG 0.42 6.8 0.35 5.05e-11 Liver disease severity in Alagille syndrome; CRC cis rs9818758 0.607 rs35060561 chr3:49255503 T/C cg07636037 chr3:49044803 WDR6 -0.66 -5.77 -0.3 1.83e-8 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; CRC cis rs11585357 0.895 rs72633814 chr1:17626456 T/C cg08277548 chr1:17600880 PADI3 -0.92 -11.74 -0.54 8.16e-27 Hair shape; CRC cis rs4689388 0.890 rs6838400 chr4:6295427 C/G cg25554036 chr4:6271136 WFS1 0.53 8.7 0.43 1.59e-16 Type 2 diabetes and other traits;Type 2 diabetes; CRC cis rs10504229 0.728 rs72650855 chr8:58152570 A/G cg22535103 chr8:58192502 C8orf71 -0.68 -8.37 -0.42 1.72e-15 Developmental language disorder (linguistic errors); CRC cis rs208520 0.770 rs2224422 chr6:66883993 G/A cg07460842 chr6:66804631 NA -0.93 -12.55 -0.57 8.48e-30 Exhaled nitric oxide output; CRC cis rs7713065 0.531 rs2522051 chr5:131797578 C/T cg18758796 chr5:131593413 PDLIM4 0.34 6.09 0.32 3.08e-9 Lung function (FEV1/FVC); CRC cis rs7772486 0.875 rs2180192 chr6:146322284 T/C cg13319975 chr6:146136371 FBXO30 -0.4 -5.98 -0.31 5.73e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs7927771 0.864 rs7107726 chr11:47429245 T/A cg20307385 chr11:47447363 PSMC3 -0.64 -9.25 -0.45 3.01e-18 Subjective well-being; CRC cis rs826838 1.000 rs1963562 chr12:38662896 C/T cg13010199 chr12:38710504 ALG10B 0.46 6.1 0.32 2.98e-9 Heart rate; CRC cis rs1552244 1.000 rs12374115 chr3:10134766 A/G cg18598329 chr3:10140678 FANCD2;C3orf24 0.83 11.25 0.53 4.49e-25 Alzheimer's disease; CRC trans rs4650994 1.000 rs10798617 chr1:178515806 T/C cg05059571 chr16:84539110 KIAA1609 -0.48 -7.33 -0.37 1.83e-12 HDL cholesterol levels;HDL cholesterol; CRC trans rs3780486 0.846 rs10124479 chr9:33136233 T/G cg04842962 chr6:43655489 MRPS18A 1.15 23.86 0.8 9.57e-74 IgG glycosylation; CRC cis rs561341 0.941 rs2428336 chr17:30290577 T/C cg00745463 chr17:30367425 LRRC37B -0.75 -8.92 -0.44 3.23e-17 Hip circumference adjusted for BMI; CRC cis rs2576037 0.526 rs626217 chr18:44429182 T/G cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.61 -9.88 -0.48 2.58e-20 Personality dimensions; CRC cis rs13191362 0.935 rs34709632 chr6:163048380 A/G cg21926612 chr6:163149169 PACRG;PARK2 0.97 12.21 0.56 1.6e-28 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs2456568 0.548 rs10466335 chr11:93663820 G/C cg26875233 chr11:93583750 C11orf90 -0.35 -6.83 -0.35 4.03e-11 Response to serotonin reuptake inhibitors in major depressive disorder; CRC cis rs889398 0.594 rs8047194 chr16:69891510 G/T cg00738113 chr16:70207722 CLEC18C -0.34 -5.89 -0.31 9.33e-9 Body mass index; CRC cis rs12908161 1.000 rs35524990 chr15:85258203 T/C cg11189052 chr15:85197271 WDR73 0.61 8.88 0.44 4.41e-17 Schizophrenia; CRC cis rs9910055 0.529 rs228757 chr17:42164885 G/C cg10896456 chr17:42255109 ASB16;C17orf65 -0.38 -5.71 -0.3 2.54e-8 Total body bone mineral density; CRC cis rs9517313 0.615 rs4772079 chr13:99090837 C/G cg20487152 chr13:99095054 FARP1 -0.48 -7.93 -0.4 3.48e-14 Neuroticism; CRC cis rs67340775 0.541 rs200964 chr6:27866943 G/C cg12273811 chr6:28175739 NA 0.61 6.33 0.33 7.99e-10 Lung cancer in ever smokers; CRC cis rs7552404 0.727 rs7521344 chr1:76318325 C/T cg22875332 chr1:76189707 ACADM -0.56 -7.4 -0.38 1.15e-12 Blood metabolite levels;Acylcarnitine levels; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg20483112 chr1:11954174 NA 0.42 5.97 0.31 6.29e-9 Response to antipsychotic treatment; CRC cis rs4253772 0.550 rs6008613 chr22:46707924 G/T cg03482458 chr22:46692211 CN5H6.4;GTSE1 0.5 6.15 0.32 2.26e-9 LDL cholesterol;Cholesterol, total; CRC cis rs28386778 0.830 rs2854210 chr17:61946338 C/A cg22520471 chr17:61851767 DDX42;CCDC47 0.73 11.27 0.53 3.96e-25 Prudent dietary pattern; CRC cis rs951366 0.589 rs823099 chr1:205669322 C/A cg17178900 chr1:205818956 PM20D1 0.65 8.98 0.44 2.12e-17 Menarche (age at onset); CRC cis rs13315871 1.000 rs71311869 chr3:58398922 C/T cg20936604 chr3:58311152 NA -0.75 -7.14 -0.37 5.96e-12 Cholesterol, total; CRC cis rs13108904 0.901 rs1316394 chr4:1315820 G/A cg16405210 chr4:1374714 KIAA1530 -0.42 -5.74 -0.3 2.17e-8 Obesity-related traits; CRC cis rs1008375 1.000 rs4698641 chr4:17642630 C/T cg16339924 chr4:17578868 LAP3 0.53 7.17 0.37 4.9e-12 Parasitemia in Tripanosoma cruzi seropositivity; CRC trans rs57221529 0.766 rs56350081 chr5:583198 G/A cg11887960 chr12:57824829 NA 0.63 6.79 0.35 5.32e-11 Lung disease severity in cystic fibrosis; CRC cis rs13118159 0.801 rs13147602 chr4:1332175 A/G cg16405210 chr4:1374714 KIAA1530 -0.51 -7.0 -0.36 1.42e-11 Longevity; CRC cis rs3790455 0.610 rs746527 chr1:156460511 C/T cg14087168 chr1:156450669 MEF2D -0.38 -6.62 -0.34 1.44e-10 Migraine; CRC cis rs9311474 0.607 rs34005367 chr3:52558904 A/T cg07507251 chr3:52567010 NT5DC2 0.49 7.37 0.38 1.37e-12 Electroencephalogram traits; CRC cis rs9926296 0.568 rs886950 chr16:89836872 T/C cg27121462 chr16:89883253 FANCA 0.58 9.28 0.46 2.31e-18 Vitiligo; CRC cis rs2739330 0.828 rs2186366 chr22:24254113 A/G cg18538332 chr22:24372958 LOC391322 0.72 11.63 0.54 2.04e-26 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs13253111 0.766 rs56232071 chr8:28063230 A/T cg26534493 chr8:28060551 NA 0.49 8.59 0.43 3.61e-16 Childhood body mass index; CRC cis rs753778 0.570 rs10875465 chr8:142210500 A/G cg23750338 chr8:142222470 SLC45A4 0.37 6.23 0.33 1.39e-9 Reticulocyte fraction of red cells;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; CRC cis rs2976388 0.669 rs2976391 chr8:143762724 C/A cg20041105 chr8:143859282 LYNX1 0.36 6.17 0.32 1.95e-9 Urinary tract infection frequency; CRC cis rs1799949 0.965 rs11657883 chr17:41330024 T/C cg23758822 chr17:41437982 NA 0.81 13.61 0.6 9.13e-34 Menopause (age at onset); CRC trans rs1728785 1.000 rs1645935 chr16:68563791 A/C cg04657470 chr2:198365150 HSPE1;HSPD1 0.57 6.78 0.35 5.72e-11 Ulcerative colitis; CRC cis rs9811920 0.609 rs809415 chr3:99582242 G/T cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G -0.46 -6.14 -0.32 2.33e-9 Axial length; CRC cis rs4727027 0.866 rs3735311 chr7:148877737 T/C cg23583168 chr7:148888333 NA -0.86 -14.69 -0.63 6.45e-38 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC cis rs6681460 0.674 rs4134135 chr1:67012728 A/G cg02459107 chr1:67143332 SGIP1 0.4 6.28 0.33 1.04e-9 Presence of antiphospholipid antibodies; CRC cis rs7769051 0.711 rs7738071 chr6:133085116 G/A cg22852734 chr6:133119734 C6orf192 0.78 8.25 0.41 3.86e-15 Type 2 diabetes nephropathy; CRC cis rs4363385 0.818 rs1890285 chr1:153015396 T/C cg25856811 chr1:152973957 SPRR3 -0.25 -6.89 -0.35 2.92e-11 Inflammatory skin disease; CRC trans rs7618501 1.000 rs6785549 chr3:49736565 G/A cg21659725 chr3:3221576 CRBN -0.91 -17.94 -0.7 1.16e-50 Intelligence (multi-trait analysis); CRC cis rs2836974 0.931 rs2836972 chr21:40652142 G/A cg11890956 chr21:40555474 PSMG1 1.11 19.05 0.72 4.69e-55 Cognitive function; CRC cis rs10857712 0.754 rs2297033 chr10:135234848 C/T cg17796960 chr10:135278976 LOC619207 -0.37 -5.65 -0.3 3.53e-8 Systemic lupus erythematosus; CRC cis rs7613875 0.641 rs6446194 chr3:50067298 T/A cg24110177 chr3:50126178 RBM5 0.58 9.07 0.45 1.07e-17 Body mass index; CRC cis rs832540 0.864 rs832576 chr5:56163255 C/A cg12311346 chr5:56204834 C5orf35 -0.45 -6.78 -0.35 5.41e-11 Coronary artery disease; CRC trans rs1814175 0.935 rs10839317 chr11:49657228 A/C cg15704280 chr7:45808275 SEPT13 -0.97 -18.29 -0.71 4.7e-52 Height; CRC cis rs17401966 0.931 rs11587854 chr1:10447622 G/A cg19773385 chr1:10388646 KIF1B -0.68 -10.91 -0.52 7.29e-24 Hepatocellular carcinoma; CRC cis rs12450688 1 rs12450688 chr17:38144229 G/A cg17344932 chr17:38183730 MED24;SNORD124 0.5 8.31 0.42 2.49e-15 Sum eosinophil basophil counts; CRC trans rs7824557 0.564 rs13260727 chr8:11232860 A/G cg06636001 chr8:8085503 FLJ10661 0.45 6.72 0.35 7.8e-11 Retinal vascular caliber; CRC cis rs12922317 0.860 rs2541583 chr16:12131121 C/T cg02368508 chr16:12060182 TNFRSF17 0.38 5.78 0.3 1.71e-8 Schizophrenia; CRC cis rs1448094 0.510 rs1993806 chr12:86147151 T/C cg06740227 chr12:86229804 RASSF9 -0.37 -5.64 -0.3 3.71e-8 Major depressive disorder; CRC cis rs7666738 0.830 rs10017201 chr4:98983561 G/A cg05340658 chr4:99064831 C4orf37 0.6 9.41 0.46 8.57e-19 Colonoscopy-negative controls vs population controls; CRC cis rs6662572 0.686 rs884443 chr1:46484421 G/C cg08644498 chr1:46502608 NA 0.46 7.29 0.37 2.31e-12 Blood protein levels; CRC cis rs3741404 0.825 rs2845597 chr11:63954370 G/A cg06219103 chr11:63990595 FERMT3 -0.4 -6.13 -0.32 2.56e-9 Platelet count; CRC cis rs7959452 0.535 rs11177577 chr12:69671791 C/T cg22834771 chr12:69754056 YEATS4 -0.41 -5.88 -0.31 1.03e-8 Blood protein levels; CRC cis rs9969804 0.905 rs7043114 chr9:95387983 C/T cg14631576 chr9:95140430 CENPP -0.31 -5.72 -0.3 2.45e-8 Height; CRC cis rs427941 0.632 rs201500 chr7:101757806 G/C cg06246474 chr7:101738831 CUX1 0.44 6.77 0.35 6.08e-11 Plasma omega-3 polyunsaturated fatty acid level (eicosapentaenoic acid); CRC trans rs875971 0.502 rs6460311 chr7:66111873 C/T cg02869306 chr7:64672164 INTS4L1 0.42 6.06 0.32 3.77e-9 Aortic root size; CRC cis rs7666738 0.791 rs2903142 chr4:99040071 C/T cg17366294 chr4:99064904 C4orf37 0.44 7.53 0.38 5.09e-13 Colonoscopy-negative controls vs population controls; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg14857596 chr12:72233493 TBC1D15 0.39 6.17 0.32 1.97e-9 Liver disease severity in Alagille syndrome; CRC cis rs3859192 0.599 rs12451897 chr17:38179275 G/T cg17344932 chr17:38183730 MED24;SNORD124 0.87 17.51 0.69 5.85e-49 White blood cell count; CRC cis rs11585357 0.895 rs72633828 chr1:17632251 G/A cg08277548 chr1:17600880 PADI3 -0.87 -11.22 -0.53 6.08e-25 Hair shape; CRC cis rs12760731 0.668 rs10913548 chr1:178372286 G/A cg00404053 chr1:178313656 RASAL2 1.16 11.74 0.54 8.13e-27 Obesity-related traits; CRC cis rs4713118 0.539 rs200988 chr6:27819353 A/C cg06470822 chr6:28175283 NA 0.75 10.79 0.51 2.01e-23 Parkinson's disease; CRC cis rs6570726 0.935 rs384453 chr6:145815145 G/C cg05347473 chr6:146136440 FBXO30 0.37 5.93 0.31 7.63e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs7224737 1.000 rs2240010 chr17:40278081 T/A cg20291162 chr17:40259547 DHX58 -0.55 -7.96 -0.4 2.8e-14 Fibrinogen levels; CRC cis rs10791323 0.627 rs2723614 chr11:133705871 T/G cg15485101 chr11:133734466 NA 0.41 6.82 0.35 4.45e-11 Childhood ear infection; CRC cis rs116095464 0.558 rs10067021 chr5:221490 C/T cg22496380 chr5:211416 CCDC127 -0.83 -9.55 -0.47 3.03e-19 Breast cancer; CRC cis rs7937682 0.924 rs11213968 chr11:111527629 G/C cg09085632 chr11:111637200 PPP2R1B -1.0 -20.18 -0.74 1.7e-59 Primary sclerosing cholangitis; CRC cis rs13108904 0.870 rs13132584 chr4:1251504 G/T cg05665937 chr4:1216051 CTBP1 0.43 6.44 0.33 4.34e-10 Obesity-related traits; CRC cis rs7727544 1.000 rs7727038 chr5:131590257 C/T cg22638593 chr5:131593259 PDLIM4 0.37 7.07 0.36 9.45e-12 Blood metabolite levels; CRC cis rs6461049 0.638 rs3778994 chr7:2175855 G/T cg21782813 chr7:2030301 MAD1L1 0.41 7.45 0.38 8.35e-13 Schizophrenia; CRC cis rs6679073 1.000 rs6679073 chr1:205756484 A/C cg23034840 chr1:205782522 SLC41A1 0.55 7.73 0.39 1.3e-13 Prostate-specific antigen levels; CRC cis rs853679 0.517 rs9348797 chr6:28137533 G/C cg15786705 chr6:28176104 NA 0.78 9.83 0.48 3.57e-20 Depression; CRC cis rs13272623 0.536 rs11985127 chr8:71743943 C/T cg23757474 chr8:71581111 LACTB2;XKR9 0.61 6.01 0.31 4.94e-9 IgG glycosylation; CRC cis rs12024301 0.557 rs76070988 chr1:183633490 G/A cg11505048 chr1:183622726 RGL1;APOBEC4 0.81 7.0 0.36 1.42e-11 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs1799949 0.965 rs11657883 chr17:41330024 T/C cg01879757 chr17:41196368 BRCA1 -0.41 -6.18 -0.32 1.86e-9 Menopause (age at onset); CRC cis rs9488822 0.676 rs11153594 chr6:116354591 A/G cg18764771 chr6:116381957 FRK -0.27 -7.93 -0.4 3.5e-14 Cholesterol, total;LDL cholesterol; CRC trans rs1814175 0.509 rs60698301 chr11:49877672 G/A cg21153622 chr11:89784906 NA -0.39 -6.17 -0.32 2.04e-9 Height; CRC cis rs2425143 0.908 rs75331436 chr20:34391052 T/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.49 -5.81 -0.3 1.51e-8 Blood protein levels; CRC trans rs7618501 0.633 rs6446193 chr3:50059758 T/C cg21665057 chr3:196295764 WDR53;FBXO45 -0.57 -9.1 -0.45 8.6e-18 Intelligence (multi-trait analysis); CRC cis rs7463659 0.935 rs7844624 chr8:135433894 T/C cg17885191 chr8:135476712 NA -0.4 -5.89 -0.31 9.64e-9 Colonoscopy-negative controls vs population controls; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg03710140 chr20:5986599 CRLS1 0.41 6.6 0.34 1.64e-10 Liver disease severity in Alagille syndrome; CRC cis rs12824058 0.844 rs7956408 chr12:130807547 A/T cg27633287 chr12:130766243 NA -0.38 -5.97 -0.31 6.31e-9 Menopause (age at onset); CRC cis rs995000 0.931 rs10158897 chr1:62912919 C/T cg19896129 chr1:63156450 NA 0.4 5.78 0.3 1.76e-8 Triglyceride levels; CRC cis rs4665809 1.000 rs4665298 chr2:26256378 G/A cg25036284 chr2:26402008 FAM59B -0.44 -5.87 -0.31 1.09e-8 Gut microbiome composition (summer); CRC cis rs1448094 0.527 rs59445394 chr12:86237843 C/T cg25456477 chr12:86230367 RASSF9 0.36 6.21 0.32 1.56e-9 Major depressive disorder; CRC cis rs4713118 0.629 rs203890 chr6:28022248 T/C cg15786705 chr6:28176104 NA 0.69 9.42 0.46 8.13e-19 Parkinson's disease; CRC cis rs7789940 0.904 rs73140040 chr7:75936240 C/T cg10167463 chr7:75959203 YWHAG -0.65 -8.65 -0.43 2.36e-16 Multiple sclerosis; CRC cis rs2032447 0.802 rs12346 chr6:26097046 T/C cg04800585 chr6:26043546 HIST1H2BB 0.5 7.31 0.37 2.04e-12 Intelligence (multi-trait analysis); CRC cis rs9372498 0.536 rs62422189 chr6:118907053 C/T cg15382696 chr6:118971807 C6orf204 0.57 7.09 0.36 8.07e-12 Diastolic blood pressure; CRC cis rs2115630 0.645 rs3825878 chr15:85174755 C/T cg12501888 chr15:85177176 SCAND2 -0.46 -7.75 -0.39 1.15e-13 P wave terminal force; CRC cis rs10911232 0.507 rs4072709 chr1:183028855 C/T ch.1.3577855R chr1:183094577 LAMC1 0.82 14.25 0.62 3.32e-36 Hypertriglyceridemia; CRC cis rs972578 0.791 rs3091382 chr22:43291095 C/T cg01576275 chr22:43409880 NA -0.38 -6.03 -0.32 4.39e-9 Mean platelet volume; CRC cis rs2929278 0.617 rs12908467 chr15:44047430 C/T cg02155558 chr15:43621948 ADAL;LCMT2 -0.46 -6.4 -0.33 5.4e-10 Schizophrenia; CRC cis rs2404602 0.692 rs56193230 chr15:76934472 C/T cg03037974 chr15:76606532 NA 0.72 12.72 0.57 1.97e-30 Blood metabolite levels; CRC cis rs6860806 0.507 rs635619 chr5:131720265 G/A cg22638593 chr5:131593259 PDLIM4 -0.39 -6.49 -0.34 3.13e-10 Breast cancer; CRC cis rs889312 0.500 rs866223 chr5:56125353 A/G cg18230493 chr5:56204884 C5orf35 -0.41 -6.03 -0.32 4.36e-9 Breast cancer;Breast cancer (early onset); CRC trans rs1728785 1.000 rs6499181 chr16:68593002 A/T cg04657470 chr2:198365150 HSPE1;HSPD1 0.59 7.14 0.37 5.95e-12 Ulcerative colitis; CRC cis rs6502050 0.835 rs8080423 chr17:80102279 A/G cg11859384 chr17:80120422 CCDC57 -0.37 -5.85 -0.31 1.16e-8 Life satisfaction; CRC cis rs1005277 0.579 rs1780133 chr10:38499509 T/C cg25427524 chr10:38739819 LOC399744 -0.78 -14.31 -0.62 1.89e-36 Extrinsic epigenetic age acceleration; CRC cis rs2070488 0.775 rs13098946 chr3:38517784 C/G cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.82 14.14 0.61 8.64e-36 Electrocardiographic conduction measures; CRC cis rs1799949 1.000 rs34572725 chr17:41428666 G/A cg23758822 chr17:41437982 NA 0.79 13.42 0.59 4.56e-33 Menopause (age at onset); CRC cis rs9614461 0.702 rs16993867 chr22:45733199 A/G cg15911859 chr22:45810043 RIBC2;SMC1B 0.56 6.0 0.31 5.14e-9 Tonsillectomy; CRC cis rs67340775 0.541 rs200979 chr6:27852357 G/A cg12273811 chr6:28175739 NA 0.57 5.79 0.3 1.61e-8 Lung cancer in ever smokers; CRC cis rs875971 0.862 rs13232191 chr7:65986648 A/G cg11764359 chr7:65958608 NA 0.59 8.81 0.44 7.57e-17 Aortic root size; CRC cis rs12325245 0.536 rs12931051 chr16:58626534 C/T cg21335942 chr16:58549945 SETD6 0.86 5.72 0.3 2.39e-8 Schizophrenia; CRC cis rs34375054 0.558 rs12578774 chr12:125681761 A/G cg06287003 chr12:125626642 AACS 0.53 7.25 0.37 3e-12 Post bronchodilator FEV1/FVC ratio; CRC cis rs6502050 0.835 rs7502676 chr17:80093433 C/G cg25804541 chr17:80189381 SLC16A3 -0.3 -5.95 -0.31 6.79e-9 Life satisfaction; CRC cis rs6089584 0.606 rs2296082 chr20:60573983 A/G cg13770153 chr20:60521292 NA -0.46 -7.58 -0.39 3.44e-13 Body mass index; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg07927484 chr5:153826296 SAP30L 0.47 6.67 0.35 1.11e-10 Response to antipsychotic treatment; CRC cis rs2857891 0.773 rs2638100 chr11:6969676 C/G cg12728517 chr11:6947552 ZNF215 0.51 5.85 0.31 1.22e-8 Response to cytadine analogues (cytosine arabinoside); CRC trans rs931812 0.895 rs4734016 chr8:101910071 C/T cg20993868 chr7:22813445 NA 0.54 9.78 0.47 5.54e-20 Attention deficit hyperactivity disorder and conduct disorder; CRC cis rs853679 0.517 rs4713141 chr6:28101678 G/C cg21251018 chr6:28226885 NKAPL 0.48 6.33 0.33 7.86e-10 Depression; CRC cis rs7731657 0.537 rs10051429 chr5:130257549 C/T cg08523029 chr5:130500466 HINT1 0.43 5.7 0.3 2.61e-8 Fasting plasma glucose; CRC cis rs2032447 0.714 rs199734 chr6:25940393 G/C cg26028573 chr6:26043587 HIST1H2BB 0.45 6.46 0.34 3.71e-10 Intelligence (multi-trait analysis); CRC trans rs7474896 0.832 rs35954589 chr10:37926383 G/A cg16724811 chr16:15130678 PDXDC1 -0.62 -6.12 -0.32 2.72e-9 Obesity (extreme); CRC cis rs1150668 0.835 rs1233696 chr6:28143010 T/C cg02683197 chr6:28174875 NA 0.47 6.68 0.35 1.04e-10 Pubertal anthropometrics; CRC cis rs16973500 0.808 rs61523290 chr16:71943556 A/G cg00732059 chr16:71740210 PHLPP2 -0.67 -6.87 -0.35 3.28e-11 Response to anti-TNF therapy in rheumatoid arthritis;Attention deficit hyperactivity disorder and conduct disorder; CRC cis rs9322193 0.923 rs62439840 chr6:149995775 G/A cg00933542 chr6:150070202 PCMT1 0.31 6.22 0.32 1.55e-9 Lung cancer; CRC cis rs9462846 0.959 rs6937172 chr6:42884375 A/T cg21280719 chr6:42927975 GNMT -0.34 -5.86 -0.31 1.1e-8 Blood protein levels; CRC cis rs11252926 0.537 rs4881255 chr10:453638 T/C cg16386425 chr10:429943 DIP2C -0.43 -6.63 -0.34 1.39e-10 Psychosis in Alzheimer's disease; CRC cis rs4665809 0.589 rs4665841 chr2:26448950 G/A cg27170947 chr2:26402098 FAM59B -0.63 -8.5 -0.42 6.81e-16 Gut microbiome composition (summer); CRC cis rs2062225 0.935 rs1842981 chr2:111763490 T/A cg11729679 chr2:111877065 BCL2L11 -0.56 -5.62 -0.3 4.08e-8 Monocyte count; CRC cis rs853679 0.517 rs9380065 chr6:28144751 A/G cg02631126 chr6:28058918 ZSCAN12L1 0.29 5.73 0.3 2.26e-8 Depression; CRC cis rs763121 0.719 rs138699 chr22:39129708 G/A cg06022373 chr22:39101656 GTPBP1 0.71 9.75 0.47 6.99e-20 Menopause (age at onset); CRC cis rs863345 0.604 rs12064489 chr1:158499449 T/C cg12129480 chr1:158549410 OR10X1 -0.3 -6.27 -0.33 1.12e-9 Pneumococcal bacteremia; CRC cis rs2228479 0.867 rs35542367 chr16:89965825 G/C cg19635926 chr16:89946313 TCF25 0.65 6.7 0.35 9.16e-11 Skin colour saturation; CRC trans rs116095464 0.558 rs60251075 chr5:245292 T/C cg00938859 chr5:1591904 SDHAP3 0.72 7.76 0.39 1.09e-13 Breast cancer; CRC cis rs6762477 0.715 rs12631337 chr3:50198537 A/G cg05623727 chr3:50126028 RBM5 -0.47 -8.05 -0.41 1.58e-14 Menarche (age at onset); CRC cis rs9303542 0.625 rs8072250 chr17:46569216 C/T cg04904318 chr17:46607828 HOXB1 -0.45 -5.73 -0.3 2.27e-8 Ovarian cancer;Epithelial ovarian cancer; CRC cis rs9467711 0.651 rs9467623 chr6:25860580 G/A cg08501292 chr6:25962987 TRIM38 1.12 9.46 0.46 6.01e-19 Autism spectrum disorder or schizophrenia; CRC cis rs873946 0.504 rs3829132 chr10:134579044 A/C cg18305652 chr10:134549665 INPP5A 0.51 7.12 0.37 6.86e-12 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CRC cis rs11191270 0.554 rs77616533 chr10:104055983 A/G cg15320455 chr10:103880129 LDB1 0.77 7.18 0.37 4.74e-12 Intelligence (multi-trait analysis); CRC cis rs4243830 0.850 rs10779787 chr1:6599755 C/G cg05709478 chr1:6581295 PLEKHG5 -0.5 -5.69 -0.3 2.83e-8 Body mass index; CRC cis rs1862618 0.853 rs1559282 chr5:56099375 T/A cg24531977 chr5:56204891 C5orf35 -0.77 -10.3 -0.49 9.5e-22 Initial pursuit acceleration; CRC cis rs898097 0.841 rs4986136 chr17:80865119 A/G cg15664640 chr17:80829946 TBCD 0.65 10.51 0.5 1.87e-22 Breast cancer; CRC cis rs739401 0.572 rs389285 chr11:3062673 G/A cg05729581 chr11:3078854 CARS -0.58 -8.37 -0.42 1.72e-15 Longevity; CRC cis rs4243830 0.850 rs12563717 chr1:6599557 T/G cg22792644 chr1:6614718 TAS1R1;NOL9 0.81 8.87 0.44 4.86e-17 Body mass index; CRC cis rs1832871 0.672 rs6933928 chr6:158747071 C/T cg07165851 chr6:158734300 TULP4 0.63 7.96 0.4 2.75e-14 Height; CRC trans rs7395662 0.500 rs1304199 chr11:48699032 A/G cg00717180 chr2:96193071 NA -0.38 -6.27 -0.33 1.15e-9 HDL cholesterol; CRC cis rs7666738 0.830 rs2167892 chr4:99048503 G/C cg05340658 chr4:99064831 C4orf37 0.6 9.35 0.46 1.4e-18 Colonoscopy-negative controls vs population controls; CRC cis rs2153535 0.541 rs1414353 chr6:8485642 C/G cg07606381 chr6:8435919 SLC35B3 0.67 10.78 0.51 2.07e-23 Motion sickness; CRC cis rs28374715 0.681 rs28687846 chr15:41599902 C/T cg18705301 chr15:41695430 NDUFAF1 -1.1 -19.05 -0.72 4.88e-55 Ulcerative colitis; CRC cis rs9322193 0.607 rs12204653 chr6:150213021 C/G cg13206674 chr6:150067644 NUP43 0.47 5.66 0.3 3.23e-8 Lung cancer; CRC trans rs9291683 0.588 rs35099040 chr4:10018839 T/C cg26043149 chr18:55253948 FECH 0.51 7.82 0.4 7.29e-14 Bone mineral density; CRC cis rs4742903 1.000 rs3780535 chr9:106894211 A/C cg21169611 chr9:106856078 SMC2 0.42 5.86 0.31 1.14e-8 High-grade serous ovarian cancer;Breast cancer; CRC cis rs765787 0.530 rs12915027 chr15:45512626 G/A cg24006582 chr15:45444508 DUOX1 0.52 7.53 0.38 4.87e-13 Uric acid levels; CRC cis rs6942756 0.806 rs6967464 chr7:128909727 T/C cg02491457 chr7:128862824 NA 0.7 9.67 0.47 1.25e-19 White matter hyperintensity burden; CRC trans rs1814175 0.645 rs10128563 chr11:50023681 T/C cg15704280 chr7:45808275 SEPT13 -0.92 -16.92 -0.68 1.2e-46 Height; CRC cis rs1348850 0.958 rs4893941 chr2:178269531 A/T cg22681709 chr2:178499509 PDE11A -0.39 -7.35 -0.38 1.61e-12 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs62244186 0.659 rs1806579 chr3:44509281 T/C cg11003573 chr3:44754125 ZNF502 -0.33 -5.68 -0.3 3e-8 Depressive symptoms; CRC cis rs853679 0.599 rs202906 chr6:28011652 C/T cg03623178 chr6:28175578 NA -0.82 -7.95 -0.4 2.94e-14 Depression; CRC cis rs5750830 0.649 rs7949 chr22:39827553 G/A cg25956985 chr22:39795188 MAP3K7IP1 -0.44 -6.53 -0.34 2.57e-10 Intelligence (multi-trait analysis); CRC cis rs8005677 1.000 rs8006409 chr14:23396511 A/G cg25600027 chr14:23388339 RBM23 -0.51 -8.05 -0.41 1.58e-14 Cognitive ability (multi-trait analysis); CRC cis rs802075 1.000 rs360564 chr6:49658090 T/C cg20364632 chr6:49636226 NA -0.36 -5.87 -0.31 1.05e-8 Bone mineral density (hip) and age at menarche; CRC cis rs4076764 0.801 rs6675964 chr1:163375960 A/G cg24596788 chr1:163392923 NA -0.64 -10.48 -0.5 2.36e-22 Motion sickness; CRC cis rs4474465 0.850 rs10899538 chr11:78237749 C/T cg27205649 chr11:78285834 NARS2 0.49 6.2 0.32 1.65e-9 Alzheimer's disease (survival time); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg19909895 chr3:128368930 RPN1 0.45 6.25 0.33 1.27e-9 Response to antipsychotic treatment; CRC cis rs2412459 1.000 rs2279581 chr15:40300092 A/G cg16127683 chr15:40268777 EIF2AK4 -0.63 -6.26 -0.33 1.2e-9 Response to haloperidol in psychosis; CRC cis rs7208859 0.614 rs73265646 chr17:29244023 C/T cg13385521 chr17:29058706 SUZ12P 0.68 7.91 0.4 4.06e-14 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs1552244 1.000 rs17032299 chr3:10087638 C/T cg10729496 chr3:10149963 C3orf24 0.53 7.04 0.36 1.12e-11 Alzheimer's disease; CRC cis rs1862618 0.573 rs2591962 chr5:56237155 G/A cg20203395 chr5:56204925 C5orf35 0.8 9.74 0.47 7.54e-20 Initial pursuit acceleration; CRC cis rs1552244 1.000 rs57631744 chr3:10118962 T/C cg13047869 chr3:10149882 C3orf24 0.53 7.53 0.38 5e-13 Alzheimer's disease; CRC cis rs629535 0.814 rs78813708 chr8:70073977 A/G cg26132723 chr8:70041827 NA 0.35 5.71 0.3 2.51e-8 Dupuytren's disease; CRC trans rs10983614 1.000 rs7867776 chr9:120072627 A/G cg09700085 chr3:45838028 SLC6A20 0.48 6.33 0.33 7.9e-10 Survival in pancreatic cancer; CRC cis rs11785400 0.793 rs3735993 chr8:143741170 G/A cg24634471 chr8:143751801 JRK 0.47 6.33 0.33 8.18e-10 Schizophrenia; CRC cis rs9648716 1.000 rs1267645 chr7:140485335 T/C cg10747023 chr7:140774559 NA 0.44 5.67 0.3 3.14e-8 Type 2 diabetes; CRC cis rs3008870 0.755 rs1925410 chr1:67365230 C/T cg08660285 chr1:67390436 MIER1;WDR78 -0.55 -7.77 -0.39 9.97e-14 Lymphocyte percentage of white cells; CRC cis rs12824058 0.831 rs4759657 chr12:130815818 G/A cg24838063 chr12:130822603 PIWIL1 0.59 9.98 0.48 1.13e-20 Menopause (age at onset); CRC trans rs4332037 0.851 rs10268609 chr7:1962163 A/C cg11693508 chr17:37793320 STARD3 0.59 7.27 0.37 2.7e-12 Bipolar disorder; CRC cis rs7192380 0.965 rs7205551 chr16:69605968 G/A cg00738113 chr16:70207722 CLEC18C -0.32 -5.63 -0.3 3.82e-8 Sjögren's syndrome; CRC cis rs4148883 0.689 rs1311621 chr4:100014018 T/C cg13256891 chr4:100009986 ADH5 0.45 6.47 0.34 3.51e-10 Alcohol dependence; CRC cis rs9467711 0.790 rs10484439 chr6:26309908 G/A cg08501292 chr6:25962987 TRIM38 0.84 6.06 0.32 3.63e-9 Autism spectrum disorder or schizophrenia; CRC cis rs10751667 0.643 rs10902245 chr11:953014 C/T cg23136738 chr11:925521 AP2A2 0.41 6.77 0.35 6e-11 Alzheimer's disease (late onset); CRC cis rs523522 1.000 rs1563333 chr12:120934407 C/T cg27279351 chr12:120934652 DYNLL1 0.75 11.35 0.53 2.12e-25 High light scatter reticulocyte count; CRC cis rs7085104 0.632 rs3781287 chr10:104595420 A/C cg15744005 chr10:104629667 AS3MT -0.35 -7.19 -0.37 4.3e-12 Immature fraction of reticulocytes;Schizophrenia; CRC cis rs6089584 0.853 rs1740367 chr20:60574834 C/T cg13770153 chr20:60521292 NA -0.65 -9.88 -0.48 2.49e-20 Body mass index; CRC cis rs7615952 0.641 rs2365019 chr3:125808135 T/C cg15145296 chr3:125709740 NA -0.57 -6.72 -0.35 8.16e-11 Blood pressure (smoking interaction); CRC cis rs875971 0.767 rs1643394 chr7:65836094 A/G cg11764359 chr7:65958608 NA 0.6 9.29 0.46 2.22e-18 Aortic root size; CRC cis rs12928939 0.954 rs8057568 chr16:71811995 G/A cg08717414 chr16:71523259 ZNF19 -0.51 -6.35 -0.33 7.13e-10 Post bronchodilator FEV1; CRC cis rs9549328 0.837 rs9549618 chr13:113628648 G/A cg24588162 chr13:113633484 MCF2L -0.43 -7.63 -0.39 2.64e-13 Systolic blood pressure; CRC cis rs8180040 0.966 rs807932 chr3:47354241 C/T cg10298567 chr3:47292165 KIF9 -0.4 -6.72 -0.35 8.24e-11 Colorectal cancer; CRC cis rs3733585 0.699 rs4408959 chr4:9948868 C/T cg00071950 chr4:10020882 SLC2A9 -0.54 -9.52 -0.46 4e-19 Cleft plate (environmental tobacco smoke interaction); CRC cis rs875971 0.508 rs10258739 chr7:66062935 A/T cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.43 -6.34 -0.33 7.76e-10 Aortic root size; CRC cis rs9311474 0.569 rs7614981 chr3:52566914 G/T cg08222913 chr3:52553049 STAB1 -0.41 -8.27 -0.41 3.28e-15 Electroencephalogram traits; CRC cis rs6570726 0.791 rs447992 chr6:145817184 C/T cg23711669 chr6:146136114 FBXO30 0.74 12.97 0.58 2.27e-31 Lobe attachment (rater-scored or self-reported); CRC cis rs910316 1.000 rs8017642 chr14:75590822 G/A cg08847533 chr14:75593920 NEK9 0.92 17.45 0.69 1.02e-48 Height; CRC cis rs35883536 0.588 rs114540631 chr1:101101249 A/G cg14515779 chr1:101123966 NA -0.33 -5.87 -0.31 1.04e-8 Monocyte count; CRC cis rs9649213 0.727 rs12113294 chr7:97910637 C/G cg00277769 chr7:97922759 BAIAP2L1 -0.46 -7.08 -0.36 8.96e-12 Prostate cancer (SNP x SNP interaction); CRC cis rs10782582 0.609 rs78556436 chr1:76352875 G/A cg10523679 chr1:76189770 ACADM -0.41 -5.75 -0.3 2e-8 Daytime sleep phenotypes; CRC cis rs2243480 1.000 rs778679 chr7:65840911 A/G cg25985355 chr7:65971099 NA -0.53 -5.98 -0.31 5.75e-9 Diabetic kidney disease; CRC cis rs7647973 0.925 rs4384984 chr3:49289878 T/G cg07636037 chr3:49044803 WDR6 0.62 7.59 0.39 3.28e-13 Menarche (age at onset); CRC cis rs67311347 1.000 rs73078163 chr3:40479958 C/T cg09455208 chr3:40491958 NA 0.5 9.78 0.47 5.49e-20 Renal cell carcinoma; CRC cis rs831571 0.519 rs13059603 chr3:63827381 C/T cg16258503 chr3:63850278 ATXN7;THOC7 0.66 8.88 0.44 4.32e-17 Type 2 diabetes; CRC cis rs9478638 0.592 rs162982 chr6:155634614 A/G cg07943832 chr6:155568918 TIAM2 0.49 6.3 0.33 9.38e-10 Electroencephalogram traits; CRC cis rs7647973 0.593 rs62262730 chr3:49808274 T/G cg03060546 chr3:49711283 APEH -0.63 -7.15 -0.37 5.63e-12 Menarche (age at onset); CRC cis rs7937682 0.961 rs1784784 chr11:111483185 C/T cg09085632 chr11:111637200 PPP2R1B -0.98 -19.97 -0.74 1.1e-58 Primary sclerosing cholangitis; CRC cis rs9393692 0.620 rs9393696 chr6:26291591 T/C cg00631329 chr6:26305371 NA -0.55 -9.35 -0.46 1.44e-18 Educational attainment; CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg02233558 chr5:127418922 SLC12A2;FLJ33630 -0.5 -5.96 -0.31 6.51e-9 Diisocyanate-induced asthma; CRC cis rs7412746 0.658 rs2864869 chr1:150734655 G/A cg17724175 chr1:150552817 MCL1 0.49 7.3 0.37 2.19e-12 Melanoma; CRC cis rs12760731 0.565 rs6701848 chr1:178156816 A/C cg00404053 chr1:178313656 RASAL2 0.95 10.07 0.49 5.84e-21 Obesity-related traits; CRC cis rs12318506 0.826 rs11180452 chr12:75693881 G/T cg04728562 chr12:75699417 CAPS2 -0.84 -6.66 -0.34 1.15e-10 Coronary artery calcification; CRC cis rs1862618 0.853 rs252910 chr5:56192983 G/A cg18230493 chr5:56204884 C5orf35 -0.79 -9.66 -0.47 1.38e-19 Initial pursuit acceleration; CRC cis rs889312 0.500 rs252906 chr5:56119190 G/T cg12311346 chr5:56204834 C5orf35 -0.45 -6.73 -0.35 7.62e-11 Breast cancer;Breast cancer (early onset); CRC cis rs4713118 0.629 rs203888 chr6:28021589 C/T cg15845792 chr6:28175446 NA 0.9 13.66 0.6 5.69e-34 Parkinson's disease; CRC cis rs2840044 1.000 rs9891800 chr17:33895015 G/C cg05299278 chr17:33885742 SLFN14 -0.41 -6.24 -0.33 1.33e-9 Response to radiotherapy in cancer (late toxicity); CRC cis rs7552404 1.000 rs2133134 chr1:76179587 G/A cg03433033 chr1:76189801 ACADM 0.82 11.22 0.53 6.16e-25 Blood metabolite levels;Acylcarnitine levels; CRC cis rs4713118 0.955 rs9468200 chr6:27683063 T/A cg02683197 chr6:28174875 NA 0.56 7.16 0.37 5.29e-12 Parkinson's disease; CRC trans rs8002861 0.846 rs12428314 chr13:44476011 C/T cg17145862 chr1:211918768 LPGAT1 -0.68 -12.33 -0.56 5.61e-29 Leprosy; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg01353464 chr3:38180116 ACAA1;MYD88 0.34 6.53 0.34 2.45e-10 Liver disease severity in Alagille syndrome; CRC cis rs10504229 0.683 rs11786843 chr8:58133629 T/C cg21724239 chr8:58056113 NA 0.48 6.57 0.34 1.92e-10 Developmental language disorder (linguistic errors); CRC cis rs9372498 0.536 rs9489460 chr6:118925754 C/T cg22561889 chr6:118971681 C6orf204 0.5 6.25 0.33 1.24e-9 Diastolic blood pressure; CRC cis rs9783347 0.961 rs4150588 chr11:18360131 G/A cg15585147 chr11:18324498 HPS5 0.42 6.0 0.31 5.12e-9 Pancreatic cancer; CRC cis rs7487075 0.820 rs7967669 chr12:46692991 C/T cg22049899 chr12:47219821 SLC38A4 0.32 5.95 0.31 7.01e-9 Itch intensity from mosquito bite; CRC cis rs68170813 0.641 rs75254991 chr7:106938903 C/T cg02696742 chr7:106810147 HBP1 -0.57 -6.61 -0.34 1.56e-10 Coronary artery disease; CRC cis rs12580194 0.593 rs74844018 chr12:55766871 G/A cg23425280 chr12:56401806 NA 0.47 5.74 0.3 2.13e-8 Cancer; CRC cis rs4285028 0.948 rs34543553 chr3:121675637 C/T cg20356878 chr3:121714668 ILDR1 -0.48 -6.95 -0.36 1.93e-11 Multiple sclerosis; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg04400980 chr3:121553992 IQCB1;EAF2 0.43 5.98 0.31 5.86e-9 Response to antipsychotic treatment; CRC cis rs870825 0.616 rs9715644 chr4:185632965 C/T cg04058563 chr4:185651563 MLF1IP 0.73 9.38 0.46 1.13e-18 Blood protein levels; CRC trans rs7819412 0.521 rs10110684 chr8:11039159 G/C cg16141378 chr3:129829833 LOC729375 0.42 6.11 0.32 2.81e-9 Triglycerides; CRC cis rs883565 0.569 rs784509 chr3:39166355 G/A cg01426195 chr3:39028469 NA 0.42 6.99 0.36 1.56e-11 Handedness; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg13881405 chr9:92220388 GADD45G 0.41 5.98 0.31 5.74e-9 Response to antipsychotic treatment; CRC cis rs847577 0.748 rs940430 chr7:97716540 A/G cg00277769 chr7:97922759 BAIAP2L1 -0.4 -6.78 -0.35 5.43e-11 Breast cancer; CRC cis rs7927771 0.832 rs11607981 chr11:47401060 T/G cg20307385 chr11:47447363 PSMC3 -0.62 -9.24 -0.45 3.24e-18 Subjective well-being; CRC cis rs12580194 0.593 rs7489047 chr12:55759851 A/G cg19537932 chr12:55886519 OR6C68 -0.73 -9.19 -0.45 4.43e-18 Cancer; CRC cis rs4891159 0.790 rs72975929 chr18:74144630 G/C cg24786174 chr18:74118243 ZNF516 -0.85 -14.82 -0.63 1.99e-38 Longevity; CRC cis rs4332037 0.722 rs7788921 chr7:1915282 C/A cg23422044 chr7:1970798 MAD1L1 -0.59 -7.72 -0.39 1.38e-13 Bipolar disorder; CRC cis rs11098499 0.954 rs2892848 chr4:120381341 C/T cg24375607 chr4:120327624 NA 0.5 7.71 0.39 1.46e-13 Corneal astigmatism; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg05485520 chr3:45883628 LZTFL1 0.54 7.22 0.37 3.64e-12 Thyroid stimulating hormone; CRC cis rs2243480 1.000 rs13235972 chr7:65883605 C/T cg25985355 chr7:65971099 NA -0.53 -5.98 -0.31 5.75e-9 Diabetic kidney disease; CRC cis rs7615952 0.543 rs4645102 chr3:125424441 A/G cg11143507 chr3:125485238 NA -0.57 -7.37 -0.38 1.37e-12 Blood pressure (smoking interaction); CRC cis rs881375 0.715 rs10985073 chr9:123643855 T/C cg14255062 chr9:123606675 PSMD5;LOC253039 0.39 6.13 0.32 2.51e-9 Rheumatoid arthritis; CRC cis rs875971 0.862 rs1167390 chr7:65575893 G/A cg18252515 chr7:66147081 NA 0.39 5.74 0.3 2.14e-8 Aortic root size; CRC cis rs9942416 0.660 rs194137 chr5:74978857 G/A cg00601450 chr5:74908170 NA -0.41 -5.77 -0.3 1.84e-8 Age-related disease endophenotypes; CRC cis rs7666738 0.830 rs10029849 chr4:99059362 T/C cg05340658 chr4:99064831 C4orf37 0.6 9.25 0.45 2.97e-18 Colonoscopy-negative controls vs population controls; CRC cis rs4713118 0.515 rs9368549 chr6:28050047 T/A cg23161317 chr6:28129485 ZNF389 0.5 6.21 0.32 1.57e-9 Parkinson's disease; CRC cis rs3823572 0.564 rs2953620 chr7:133666388 T/C cg03336402 chr7:133662267 EXOC4 -0.66 -10.38 -0.5 5.04e-22 Intelligence (multi-trait analysis); CRC cis rs6502050 0.835 rs8081783 chr17:80117388 G/A cg25804541 chr17:80189381 SLC16A3 -0.3 -5.88 -0.31 9.84e-9 Life satisfaction; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg23434193 chr8:74884752 TCEB1 0.6 8.06 0.41 1.47e-14 Thyroid stimulating hormone; CRC cis rs597539 0.652 rs686877 chr11:68637169 G/A cg04772025 chr11:68637568 NA 0.51 8.11 0.41 1.04e-14 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs5417 0.662 rs8067500 chr17:7172631 A/G cg25256661 chr17:7137939 DVL2 0.79 13.1 0.59 7.56e-32 Diastolic blood pressure; CRC cis rs4481887 0.893 rs10788763 chr1:248429070 A/T cg00666640 chr1:248458726 OR2T12 -0.49 -9.02 -0.45 1.63e-17 Common traits (Other); CRC cis rs9287719 0.649 rs10184776 chr2:10726446 C/T cg00105475 chr2:10696890 NA 0.44 7.0 0.36 1.43e-11 Prostate cancer; CRC cis rs1448094 0.511 rs10735486 chr12:86154352 T/A cg19622623 chr12:86230825 RASSF9 0.4 6.36 0.33 6.66e-10 Major depressive disorder; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg15425530 chr17:2415361 METT10D 0.44 6.62 0.34 1.44e-10 Liver disease severity in Alagille syndrome; CRC cis rs2046867 0.862 rs11922180 chr3:72836119 A/G cg25664220 chr3:72788482 NA 0.44 6.34 0.33 7.7e-10 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; CRC cis rs11758351 0.660 rs11753655 chr6:26220109 C/T cg01420254 chr6:26195488 NA 0.75 8.48 0.42 7.58e-16 Gout;Renal underexcretion gout; CRC trans rs9354352 0.935 rs7766730 chr6:66697003 C/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.59 8.6 0.43 3.21e-16 Initial pursuit acceleration in psychotic disorders; CRC cis rs1865760 0.713 rs6928951 chr6:25995554 C/T cg16482183 chr6:26056742 HIST1H1C 0.5 7.47 0.38 7.21e-13 Height; CRC cis rs35110281 0.715 rs969060 chr21:45080852 T/G cg04455712 chr21:45112962 RRP1B 0.41 8.02 0.4 1.82e-14 Mean corpuscular volume; CRC cis rs208520 0.874 rs208470 chr6:66916402 G/A cg07460842 chr6:66804631 NA -0.92 -12.19 -0.56 1.92e-28 Exhaled nitric oxide output; CRC trans rs10983614 1.000 rs7867776 chr9:120072627 A/G cg00628130 chr8:95908808 CCNE2 0.5 6.82 0.35 4.51e-11 Survival in pancreatic cancer; CRC cis rs3790645 1.000 rs282176 chr1:26898956 T/C cg23229016 chr1:26872525 RPS6KA1 0.25 5.98 0.31 5.89e-9 Glucose homeostasis traits; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg25088355 chr8:144691901 PYCRL 0.39 6.34 0.33 7.42e-10 Liver disease severity in Alagille syndrome; CRC cis rs9902453 0.933 rs1128156 chr17:28513176 G/A cg26525008 chr17:28256777 EFCAB5;SSH2 0.6 9.33 0.46 1.59e-18 Coffee consumption (cups per day); CRC cis rs9660992 0.674 rs12122105 chr1:205256818 C/T cg21643547 chr1:205240462 TMCC2 -0.44 -7.09 -0.36 8.02e-12 Mean corpuscular volume;Mean platelet volume; CRC cis rs909002 0.789 rs3817398 chr1:32119431 C/T cg01639898 chr1:32083012 HCRTR1 -0.3 -6.27 -0.33 1.14e-9 Intelligence (multi-trait analysis); CRC cis rs2276314 1.000 rs9304153 chr18:33562150 T/C cg05985134 chr18:33552581 C18orf21 0.45 5.88 0.31 1.03e-8 Endometriosis;Drug-induced torsades de pointes; CRC cis rs4665809 0.590 rs3806515 chr2:26466975 C/T cg04944784 chr2:26401820 FAM59B 0.83 10.74 0.51 2.96e-23 Gut microbiome composition (summer); CRC trans rs9747201 0.894 rs9944398 chr17:80177439 A/G cg07393940 chr7:158741817 NA 0.5 7.05 0.36 1.05e-11 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs2153535 0.623 rs2327055 chr6:8443145 A/G cg07606381 chr6:8435919 SLC35B3 0.68 10.94 0.52 5.78e-24 Motion sickness; CRC cis rs3796352 1.000 rs13092352 chr3:52969697 C/T cg27565382 chr3:53032988 SFMBT1 0.7 6.16 0.32 2.07e-9 Immune reponse to smallpox (secreted IL-2); CRC cis rs1868673 1.000 rs9784281 chr3:150159779 C/G cg04908077 chr3:150187338 NA -0.33 -5.64 -0.3 3.58e-8 Waist circumference; CRC cis rs909674 0.524 rs5750821 chr22:39825492 A/T cg11247378 chr22:39784982 NA -0.47 -9.2 -0.45 4.12e-18 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; CRC cis rs7517126 1.000 rs7519492 chr1:196840125 T/C cg13682187 chr1:196946512 CFHR5 -0.37 -5.97 -0.31 6.03e-9 Blood protein levels; CRC cis rs172166 0.611 rs203883 chr6:28078356 A/G cg12172441 chr6:28176163 NA 0.53 7.17 0.37 5.02e-12 Cardiac Troponin-T levels; CRC trans rs116095464 0.558 rs7713524 chr5:276200 C/T cg00938859 chr5:1591904 SDHAP3 -0.7 -7.37 -0.38 1.41e-12 Breast cancer; CRC cis rs7666738 0.830 rs35433756 chr4:99070555 C/T cg05340658 chr4:99064831 C4orf37 0.6 9.32 0.46 1.72e-18 Colonoscopy-negative controls vs population controls; CRC cis rs1320333 0.685 rs6710875 chr2:699976 A/G cg00500140 chr2:691012 NA -0.55 -6.72 -0.35 7.83e-11 Obesity-related traits; CRC cis rs6761276 0.780 rs12477867 chr2:113835919 C/A cg24553058 chr2:113831203 IL1F10 0.39 6.3 0.33 9.43e-10 Protein quantitative trait loci; CRC cis rs9911578 0.967 rs686425 chr17:56776730 A/G cg05425664 chr17:57184151 TRIM37 -0.5 -7.93 -0.4 3.41e-14 Intelligence (multi-trait analysis); CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg07796735 chr12:49932860 KCNH3 0.45 6.06 0.32 3.73e-9 Anxiety disorder; CRC cis rs490234 0.702 rs4838274 chr9:128345994 C/A cg14078157 chr9:128172775 NA -0.39 -6.43 -0.33 4.44e-10 Mean arterial pressure; CRC trans rs9858542 0.953 rs9821311 chr3:49543656 C/T cg21659725 chr3:3221576 CRBN -0.68 -9.33 -0.46 1.64e-18 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs59574136 1 rs59574136 chr7:2036460 T/C cg22963979 chr7:1858916 MAD1L1 -0.52 -7.76 -0.39 1.08e-13 Autism spectrum disorder or schizophrenia; CRC cis rs3096299 0.606 rs4785573 chr16:89565403 A/G cg05320533 chr16:89541815 ANKRD11 -0.43 -5.99 -0.31 5.57e-9 Multiple myeloma (IgH translocation); CRC cis rs7223966 1.000 rs16947005 chr17:61702989 C/T cg23090583 chr17:61904693 PSMC5;FTSJ3 -0.46 -5.87 -0.31 1.04e-8 Hip circumference adjusted for BMI;Body mass index; CRC cis rs8060686 0.516 rs12599238 chr16:68276235 G/A cg26727032 chr16:67993705 SLC12A4 -0.59 -6.41 -0.33 4.93e-10 HDL cholesterol;Metabolic syndrome; CRC cis rs9976767 0.932 rs28371062 chr21:43828267 C/T cg23042151 chr21:43824109 UBASH3A -0.37 -6.44 -0.33 4.17e-10 Type 1 diabetes; CRC cis rs3889199 0.851 rs12561822 chr1:59673745 T/C cg25881383 chr1:59680599 NA -0.38 -6.05 -0.32 4.05e-9 Pulse pressure; CRC cis rs1448094 0.511 rs17279338 chr12:86162874 G/A cg00310523 chr12:86230176 RASSF9 0.36 5.91 0.31 8.34e-9 Major depressive disorder; CRC cis rs17711722 0.523 rs313812 chr7:65505043 T/C cg18876405 chr7:65276391 NA -0.5 -8.47 -0.42 8.02e-16 Calcium levels; CRC cis rs4862750 0.872 rs6852907 chr4:187897094 A/C cg07414643 chr4:187882934 NA 0.4 6.98 0.36 1.59e-11 Lobe attachment (rater-scored or self-reported); CRC trans rs7395662 0.700 rs11493668 chr11:48727582 G/A cg21153622 chr11:89784906 NA -0.48 -7.72 -0.39 1.45e-13 HDL cholesterol; CRC cis rs965469 0.779 rs6037566 chr20:3331414 A/C cg25506879 chr20:3388711 C20orf194 -0.37 -5.76 -0.3 1.91e-8 IFN-related cytopenia; CRC cis rs9902453 0.845 rs2617875 chr17:28090024 G/T cg26525008 chr17:28256777 EFCAB5;SSH2 0.58 8.53 0.43 5.28e-16 Coffee consumption (cups per day); CRC cis rs875971 0.522 rs2008188 chr7:65429013 G/C cg05627663 chr7:65219948 SNORA22;CCT6P1 0.48 7.14 0.37 6.01e-12 Aortic root size; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg01956158 chr8:132916947 EFR3A 0.46 6.42 0.33 4.87e-10 Response to antipsychotic treatment; CRC cis rs1552244 0.882 rs7633769 chr3:10020622 C/T cg10729496 chr3:10149963 C3orf24 0.45 6.08 0.32 3.26e-9 Alzheimer's disease; CRC cis rs4680 1.000 rs165656 chr22:19948863 C/G cg22546130 chr22:19950026 COMT -0.25 -7.05 -0.36 1.03e-11 Blood metabolite levels; CRC cis rs62458065 0.513 rs702831 chr7:32579715 C/T cg20159608 chr7:32802032 NA -0.62 -8.01 -0.4 2.04e-14 Metabolite levels (HVA/MHPG ratio); CRC cis rs3733585 0.699 rs11724510 chr4:9958583 C/T cg11266682 chr4:10021025 SLC2A9 -0.48 -9.86 -0.48 2.88e-20 Cleft plate (environmental tobacco smoke interaction); CRC cis rs875971 0.789 rs7808013 chr7:66071196 A/G cg12463550 chr7:65579703 CRCP -0.47 -6.3 -0.33 9.38e-10 Aortic root size; CRC cis rs7044106 0.762 rs1547268 chr9:123408688 T/C cg09419670 chr9:123605666 PSMD5;LOC253039 0.7 10.68 0.51 4.84e-23 Hip circumference adjusted for BMI; CRC cis rs2749592 0.918 rs1208653 chr10:38253826 C/G cg25427524 chr10:38739819 LOC399744 0.65 9.68 0.47 1.14e-19 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs8060686 0.858 rs8051587 chr16:67796315 A/C cg07125278 chr16:67683757 RLTPR -0.49 -6.5 -0.34 2.93e-10 HDL cholesterol;Metabolic syndrome; CRC cis rs1008375 1.000 rs11737138 chr4:17657986 G/A cg02297831 chr4:17616191 MED28 0.44 5.81 0.31 1.45e-8 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs11098499 1.000 rs58601355 chr4:120186367 T/C cg24375607 chr4:120327624 NA 0.47 7.32 0.37 1.95e-12 Corneal astigmatism; CRC trans rs10506458 1.000 rs11174759 chr12:63444363 A/T cg22491629 chr6:157744540 C6orf35 -0.72 -8.71 -0.43 1.54e-16 Hemostatic factors and hematological phenotypes; CRC cis rs6460942 0.915 rs62447642 chr7:12489147 T/C cg06484146 chr7:12443880 VWDE -0.78 -8.09 -0.41 1.16e-14 Coronary artery disease; CRC cis rs12620999 0.838 rs13007071 chr2:238038755 A/G cg23555395 chr2:238036564 NA -0.62 -9.77 -0.47 5.67e-20 Systemic lupus erythematosus; CRC cis rs362272 0.545 rs2749783 chr4:3326098 A/C cg02993699 chr4:3415135 RGS12 -0.38 -6.49 -0.34 3.09e-10 Serum sulfate level; CRC cis rs2976388 1.000 rs2920296 chr8:143763109 A/G cg22687807 chr8:143858763 LYNX1 -0.37 -6.47 -0.34 3.46e-10 Urinary tract infection frequency; CRC cis rs11758351 1.000 rs17598927 chr6:26184640 C/G cg01420254 chr6:26195488 NA -0.84 -8.78 -0.44 9.23e-17 Gout;Renal underexcretion gout; CRC cis rs7528419 1.000 rs12740374 chr1:109817590 G/T cg00908766 chr1:109817496 CELSR2 -0.52 -9.56 -0.47 2.93e-19 Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease);Myocardial infarction;Lipoprotein-associated phospholipase A2 activity and mass;Lipoprotein-associated phospholipase A2 activity change in response to darapladib treatment in cardiovascular disease;Cholesterol, total;Coronary artery disease; CRC cis rs7659604 1.000 rs35224452 chr4:122664677 C/T cg19748678 chr4:122722346 EXOSC9 0.54 8.66 0.43 2.11e-16 Type 2 diabetes; CRC cis rs2463822 0.925 rs1881535 chr11:62121623 C/T cg06239285 chr11:62104954 ASRGL1 0.96 11.01 0.52 3.29e-24 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs61008539 0.893 rs4721502 chr7:862186 A/G cg00934597 chr7:893267 UNC84A -0.58 -8.06 -0.41 1.43e-14 Perceived unattractiveness to mosquitoes; CRC cis rs7647973 0.626 rs6809879 chr3:49834571 A/G cg03060546 chr3:49711283 APEH -0.63 -7.69 -0.39 1.69e-13 Menarche (age at onset); CRC cis rs13108904 0.875 rs10024013 chr4:1280792 C/T cg15763984 chr4:1342303 KIAA1530 -0.33 -5.61 -0.3 4.35e-8 Obesity-related traits; CRC cis rs34172651 0.537 rs8049014 chr16:24698903 A/G cg02428538 chr16:24856791 SLC5A11 -0.54 -6.48 -0.34 3.25e-10 Intelligence (multi-trait analysis); CRC cis rs4466137 0.868 rs4703962 chr5:82999808 A/G cg15083037 chr5:83017644 HAPLN1 -0.51 -6.75 -0.35 6.56e-11 Prostate cancer; CRC cis rs9325144 0.560 rs10506127 chr12:39126686 C/G cg26384229 chr12:38710491 ALG10B -0.53 -7.97 -0.4 2.57e-14 Morning vs. evening chronotype; CRC cis rs853679 0.769 rs7752448 chr6:28301099 A/G cg06470822 chr6:28175283 NA 0.83 7.71 0.39 1.49e-13 Depression; CRC cis rs870825 0.616 rs7680779 chr4:185652830 G/C cg07424746 chr4:185654737 MLF1IP 0.51 5.69 0.3 2.8e-8 Blood protein levels; CRC cis rs4888262 0.545 rs8050624 chr16:74686690 A/G cg01733217 chr16:74700730 RFWD3 -0.79 -12.19 -0.56 1.84e-28 Testicular germ cell tumor; CRC cis rs7584330 0.554 rs6739456 chr2:238385092 G/C cg14458575 chr2:238380390 NA 0.68 8.89 0.44 4.26e-17 Prostate cancer; CRC cis rs9491140 0.539 rs11154224 chr6:124678535 G/A cg05308643 chr6:124982296 NKAIN2 0.49 6.83 0.35 4.15e-11 Neuroticism; CRC cis rs10751667 0.643 rs10794352 chr11:946294 T/C cg23136738 chr11:925521 AP2A2 -0.42 -7.07 -0.36 9.13e-12 Alzheimer's disease (late onset); CRC cis rs4908768 0.501 rs7527389 chr1:8556545 A/G cg20416874 chr1:8611966 RERE -0.45 -6.42 -0.33 4.68e-10 Neuroticism (multi-trait analysis);Subjective well-being (multi-trait analysis); CRC cis rs1005277 0.579 rs1740745 chr10:38520056 T/C cg17219203 chr10:38645113 HSD17B7P2 -0.41 -5.92 -0.31 8.11e-9 Extrinsic epigenetic age acceleration; CRC cis rs2658782 0.688 rs2658768 chr11:93250827 T/C cg15737290 chr11:93063684 CCDC67 0.57 7.95 0.4 3.08e-14 Pulmonary function decline; CRC cis rs6952808 0.501 rs3778999 chr7:2180885 G/A cg04267008 chr7:1944627 MAD1L1 -0.62 -8.42 -0.42 1.18e-15 Bipolar disorder and schizophrenia; CRC cis rs1577917 0.883 rs2782263 chr6:86791307 A/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.45 -6.04 -0.32 4.1e-9 Response to antipsychotic treatment; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg06254406 chr13:103450982 BIVM;KDELC1 0.48 6.26 0.33 1.17e-9 Anxiety disorder; CRC cis rs853679 0.517 rs4713135 chr6:28039586 G/A cg18032046 chr6:28092343 ZSCAN16 -0.49 -5.83 -0.31 1.31e-8 Depression; CRC cis rs3790455 0.610 rs1171554 chr1:156474119 G/A cg14087168 chr1:156450669 MEF2D -0.35 -5.99 -0.31 5.39e-9 Migraine; CRC cis rs300703 0.515 rs300694 chr2:182277 G/T cg21211680 chr2:198530 NA -0.71 -9.44 -0.46 6.94e-19 Blood protein levels; CRC cis rs9926296 0.581 rs2108838 chr16:89904426 A/G cg03605463 chr16:89740564 NA -0.4 -5.69 -0.3 2.87e-8 Vitiligo; CRC cis rs9381040 0.674 rs4711657 chr6:41162715 G/A cg09580153 chr6:41068724 NFYA;LOC221442 -0.52 -7.37 -0.38 1.37e-12 Alzheimer's disease (late onset); CRC cis rs6540559 1.000 rs742215 chr1:209961023 A/T cg25204440 chr1:209979598 IRF6 0.45 6.0 0.31 5.11e-9 Cleft lip with or without cleft palate; CRC cis rs35110281 0.715 rs2838353 chr21:45119228 C/T cg21573476 chr21:45109991 RRP1B -0.39 -5.9 -0.31 8.97e-9 Mean corpuscular volume; CRC cis rs8072100 0.738 rs3736438 chr17:45486651 T/G cg25173405 chr17:45401733 C17orf57 -0.43 -6.5 -0.34 2.93e-10 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs7216064 1.000 rs11869819 chr17:65868669 A/C cg12091567 chr17:66097778 LOC651250 -0.67 -7.79 -0.39 8.84e-14 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CRC cis rs7647973 1.000 rs2177268 chr3:49439725 A/T cg07636037 chr3:49044803 WDR6 -0.65 -7.81 -0.4 7.8e-14 Menarche (age at onset); CRC cis rs11229555 0.645 rs12291551 chr11:58176915 T/A cg15696309 chr11:58395628 NA -0.81 -10.45 -0.5 2.9e-22 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; CRC cis rs7833986 1.000 rs34480844 chr8:57092973 G/A cg23139584 chr8:56987506 RPS20;SNORD54 0.53 6.84 0.35 3.95e-11 Height; CRC cis rs9462027 0.628 rs3734268 chr6:34716028 A/G cg07306190 chr6:34760872 UHRF1BP1 -0.35 -6.25 -0.33 1.28e-9 Systemic lupus erythematosus; CRC cis rs7666738 0.830 rs13115356 chr4:98933171 T/C cg17366294 chr4:99064904 C4orf37 0.43 7.32 0.37 1.95e-12 Colonoscopy-negative controls vs population controls; CRC cis rs10256972 0.521 rs10280960 chr7:1103697 A/G cg16145915 chr7:1198662 ZFAND2A -0.33 -6.81 -0.35 4.64e-11 Longevity;Endometriosis; CRC cis rs514406 0.861 rs2477741 chr1:53265278 A/G cg24675658 chr1:53192096 ZYG11B 0.56 8.11 0.41 1.04e-14 Monocyte count; CRC cis rs3760982 0.626 rs12463370 chr19:44292166 G/A cg21496419 chr19:44306685 LYPD5 0.35 6.52 0.34 2.6e-10 Breast cancer (estrogen-receptor negative);Breast cancer; CRC cis rs10463316 0.832 rs1019467 chr5:150734323 A/G cg03212797 chr5:150827313 SLC36A1 -0.51 -7.91 -0.4 3.88e-14 Metabolite levels (Pyroglutamine); CRC cis rs3806843 0.900 rs2563280 chr5:140131530 G/C cg16607685 chr5:140181889 PCDHA2;PCDHA1;PCDHA3 0.26 5.93 0.31 7.73e-9 Depressive symptoms (multi-trait analysis); CRC cis rs780096 0.526 rs4582 chr2:27604279 A/G cg12648201 chr2:27665141 KRTCAP3 -0.29 -5.72 -0.3 2.4e-8 Total body bone mineral density; CRC cis rs6860806 0.507 rs200837 chr5:131699958 G/A cg24060327 chr5:131705240 SLC22A5 -0.51 -7.61 -0.39 2.92e-13 Breast cancer; CRC cis rs10791323 0.582 rs2851120 chr11:133708065 A/G cg03690763 chr11:133734501 NA -0.37 -6.25 -0.33 1.27e-9 Childhood ear infection; CRC cis rs2404602 0.647 rs11632765 chr15:76974261 A/T cg23625390 chr15:77176239 SCAPER 0.84 14.27 0.62 2.74e-36 Blood metabolite levels; CRC cis rs1784581 0.631 rs3016544 chr6:162393065 T/C cg17173639 chr6:162384350 PARK2 -0.7 -11.86 -0.55 2.99e-27 Itch intensity from mosquito bite; CRC trans rs1814175 0.935 rs7925863 chr11:49615802 C/A cg03929089 chr4:120376271 NA -0.94 -17.2 -0.69 9.43e-48 Height; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg26149223 chr2:179345173 MIR548N;PLEKHA3 0.42 6.31 0.33 9.12e-10 Intelligence (multi-trait analysis); CRC cis rs3820068 0.603 rs72645900 chr1:15931980 A/T cg27534772 chr1:16042836 PLEKHM2 0.54 10.58 0.5 1.03e-22 Systolic blood pressure; CRC cis rs2976388 0.590 rs10110970 chr8:143820410 G/C cg24046110 chr8:143859143 LYNX1 -0.43 -6.91 -0.36 2.52e-11 Urinary tract infection frequency; CRC cis rs12497850 0.931 rs9846123 chr3:49088112 C/T cg07636037 chr3:49044803 WDR6 -1.02 -18.27 -0.71 5.62e-52 Parkinson's disease; CRC cis rs2243480 1.000 rs6958289 chr7:65657111 T/G cg18252515 chr7:66147081 NA 1.28 14.8 0.63 2.39e-38 Diabetic kidney disease; CRC cis rs4969178 0.622 rs11657987 chr17:76387363 G/T cg02319466 chr17:76381040 PGS1 0.36 5.61 0.3 4.3e-8 HDL cholesterol levels; CRC cis rs1003719 0.667 rs3753073 chr21:38466615 A/G cg10648535 chr21:38446584 PIGP;TTC3 0.46 6.26 0.33 1.21e-9 Eye color traits; CRC cis rs6582630 0.599 rs8175936 chr12:38426315 C/G cg26384229 chr12:38710491 ALG10B -0.53 -7.57 -0.38 3.88e-13 Drug-induced liver injury (flucloxacillin); CRC cis rs6500602 0.627 rs841231 chr16:4583147 C/T cg08645402 chr16:4508243 NA -0.57 -9.07 -0.45 1.09e-17 Schizophrenia; CRC cis rs56235845 0.964 rs11746443 chr5:176798306 G/A cg17509989 chr5:176798049 RGS14 0.83 13.44 0.6 3.92e-33 Hemoglobin concentration;Hematocrit; CRC cis rs523516 0.645 rs657723 chr17:37319103 T/C cg20555674 chr17:37321631 ARL5C 0.38 7.82 0.4 7.19e-14 IgG glycosylation; CRC cis rs9816226 0.591 rs74607912 chr3:185818559 G/A cg00760338 chr3:185826511 ETV5 -0.64 -5.63 -0.3 3.93e-8 Obesity;Body mass index; CRC trans rs61101201 0.962 rs10835790 chr11:31610022 C/T cg10667969 chr3:149181941 NA -0.53 -6.07 -0.32 3.53e-9 Optic disc area; CRC cis rs4319547 0.695 rs6488939 chr12:122858250 T/C cg05707623 chr12:122985044 ZCCHC8 -0.59 -7.38 -0.38 1.32e-12 Body mass index; CRC cis rs4919694 0.808 rs80020194 chr10:105035954 A/G cg04362960 chr10:104952993 NT5C2 1.11 9.09 0.45 9.52e-18 Arsenic metabolism; CRC cis rs1862618 0.853 rs832554 chr5:56115036 A/G cg20203395 chr5:56204925 C5orf35 -0.65 -7.76 -0.39 1.06e-13 Initial pursuit acceleration; CRC cis rs1552244 0.882 rs6443279 chr3:10053599 C/A cg00166722 chr3:10149974 C3orf24 0.63 8.16 0.41 7.3e-15 Alzheimer's disease; CRC cis rs9926296 0.605 rs6500453 chr16:89858657 C/G cg21285383 chr16:89894308 SPIRE2 0.35 6.01 0.31 4.92e-9 Vitiligo; CRC cis rs6909279 0.678 rs11753987 chr6:151851428 T/C cg10883421 chr6:151773342 RMND1;C6orf211 -0.39 -6.01 -0.31 5.06e-9 Bone mineral density; CRC trans rs9467711 0.606 rs9393715 chr6:26375645 G/A cg06606381 chr12:133084897 FBRSL1 -0.75 -5.99 -0.31 5.61e-9 Autism spectrum disorder or schizophrenia; CRC cis rs72781680 0.898 rs111460347 chr2:24018833 G/A cg08917208 chr2:24149416 ATAD2B 0.84 8.38 0.42 1.6e-15 Lymphocyte counts; CRC trans rs7512552 1.000 rs7512552 chr1:150265704 T/C cg26040332 chr1:27960788 FGR 0.32 6.13 0.32 2.5e-9 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); CRC trans rs875971 0.660 rs2191268 chr7:66110224 C/T cg25608569 chr9:6008675 KIAA2026 -0.4 -6.22 -0.32 1.54e-9 Aortic root size; CRC cis rs6424115 0.830 rs2501426 chr1:24199364 G/A cg09473613 chr1:24152604 HMGCL 0.35 5.66 0.3 3.35e-8 Immature fraction of reticulocytes; CRC cis rs28437878 1 rs28437878 chr15:78807872 C/T cg06917634 chr15:78832804 PSMA4 -0.48 -5.67 -0.3 3.18e-8 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; CRC cis rs7552404 1.000 rs72686191 chr1:76218319 G/T cg03433033 chr1:76189801 ACADM 0.83 11.32 0.53 2.6e-25 Blood metabolite levels;Acylcarnitine levels; CRC cis rs4253772 0.591 rs6008545 chr22:46686375 C/T cg24881330 chr22:46731750 TRMU 0.67 8.4 0.42 1.33e-15 LDL cholesterol;Cholesterol, total; CRC cis rs4481887 0.636 rs4397683 chr1:248411089 C/T cg00666640 chr1:248458726 OR2T12 0.51 8.97 0.44 2.31e-17 Common traits (Other); CRC cis rs6694672 0.867 rs616675 chr1:197257556 C/T cg13682187 chr1:196946512 CFHR5 0.5 7.05 0.36 1.05e-11 Asthma; CRC cis rs6499255 1.000 rs12596679 chr16:69822680 A/G cg04110750 chr16:69646130 NFAT5 0.52 7.05 0.36 1.07e-11 IgE levels; CRC cis rs9311676 0.632 rs62259772 chr3:58417416 C/T cg06643156 chr3:58380774 PXK 0.42 6.43 0.33 4.39e-10 Systemic lupus erythematosus; CRC cis rs7113874 0.544 rs9704807 chr11:8578771 G/C cg20771178 chr11:8615675 STK33 -0.34 -5.61 -0.3 4.21e-8 Body mass index in physically active individuals;Body mass index (joint analysis main effects and physical activity interaction); CRC trans rs8073060 0.544 rs225283 chr17:33934912 A/G cg19694781 chr19:47549865 TMEM160 -1.04 -14.44 -0.62 6.2e-37 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; CRC cis rs12983728 0.831 rs35081008 chr19:58662235 C/T cg21294424 chr19:58662284 ZNF329 0.85 9.53 0.47 3.54e-19 Cholesterol, total; CRC cis rs7246657 0.943 rs8106839 chr19:37958475 C/G cg23950597 chr19:37808831 NA -0.51 -6.29 -0.33 1e-9 Coronary artery calcification; CRC cis rs883565 0.528 rs11716902 chr3:38958010 G/T cg01426195 chr3:39028469 NA 0.42 7.05 0.36 1.05e-11 Handedness; CRC cis rs354033 0.918 rs67256453 chr7:149314756 T/C cg24335155 chr7:149193227 ZNF746 0.38 6.02 0.32 4.59e-9 Multiple sclerosis; CRC cis rs477692 1.000 rs477692 chr10:131426022 T/C cg26102564 chr10:131424627 MGMT 0.38 5.67 0.3 3.05e-8 Response to temozolomide; CRC cis rs2629540 0.882 rs10901813 chr10:126429875 G/A cg08799069 chr10:126477246 METTL10 -0.64 -8.32 -0.42 2.33e-15 Cocaine dependence; CRC cis rs10504229 0.683 rs11785260 chr8:58132906 A/G cg22535103 chr8:58192502 C8orf71 -0.7 -9.34 -0.46 1.47e-18 Developmental language disorder (linguistic errors); CRC cis rs1843834 0.539 rs6739735 chr2:225405253 A/G cg22509189 chr2:225307070 NA 0.38 5.82 0.31 1.36e-8 IgE levels in asthmatics (D.p. specific); CRC cis rs9462846 1.000 rs56158882 chr6:42860740 T/G cg02353165 chr6:42928485 GNMT 0.54 6.91 0.36 2.57e-11 Blood protein levels; CRC cis rs9650657 0.504 rs10109167 chr8:11033525 C/T cg27411982 chr8:10470053 RP1L1 -0.35 -5.74 -0.3 2.2e-8 Neuroticism; CRC cis rs1451375 1.000 rs2329342 chr7:50624971 A/G cg14593290 chr7:50529359 DDC -0.56 -7.68 -0.39 1.82e-13 Malaria; CRC cis rs2033711 0.783 rs8113810 chr19:58932106 A/G cg13877915 chr19:58951672 ZNF132 0.51 8.38 0.42 1.52e-15 Uric acid clearance; CRC cis rs9309711 0.623 rs7569694 chr2:3483390 T/G cg15541040 chr2:3486749 NA -0.52 -8.37 -0.42 1.68e-15 Neurofibrillary tangles; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg20786246 chr2:72377174 NA 0.42 5.98 0.31 5.84e-9 Response to antipsychotic treatment; CRC cis rs6089584 0.861 rs2180302 chr20:60576369 A/G cg18761221 chr20:60518478 NA 0.41 7.18 0.37 4.57e-12 Body mass index; CRC cis rs28386778 0.830 rs2665798 chr17:61921397 C/T cg06601766 chr17:61851465 DDX42;CCDC47 0.44 5.94 0.31 7.26e-9 Prudent dietary pattern; CRC cis rs9322193 0.923 rs10872645 chr6:150063976 G/A cg05861140 chr6:150128134 PCMT1 -0.42 -6.95 -0.36 1.91e-11 Lung cancer; CRC cis rs4474465 0.833 rs10899540 chr11:78245549 T/A cg27205649 chr11:78285834 NARS2 0.49 6.29 0.33 9.88e-10 Alzheimer's disease (survival time); CRC cis rs2842992 0.789 rs2842969 chr6:160145364 C/T cg19482086 chr6:160211437 TCP1;MRPL18 0.7 8.77 0.44 9.87e-17 Age-related macular degeneration (geographic atrophy); CRC cis rs10504229 0.683 rs72650847 chr8:58136825 C/T cg05313129 chr8:58192883 C8orf71 -0.48 -5.63 -0.3 3.78e-8 Developmental language disorder (linguistic errors); CRC cis rs2228479 0.717 rs2270460 chr16:89972416 C/A cg12064134 chr16:90016061 DEF8 -0.56 -5.66 -0.3 3.29e-8 Skin colour saturation; CRC cis rs4363385 0.693 rs608509 chr1:153034650 G/C cg25856811 chr1:152973957 SPRR3 -0.24 -6.6 -0.34 1.62e-10 Inflammatory skin disease; CRC cis rs4891159 0.548 rs660342 chr18:74130896 C/G cg24786174 chr18:74118243 ZNF516 0.9 21.39 0.76 3.25e-64 Longevity; CRC cis rs9487051 1.000 rs9374080 chr6:109616420 C/T cg01475377 chr6:109611718 NA 0.46 8.27 0.41 3.39e-15 Reticulocyte fraction of red cells; CRC cis rs7923452 0.507 rs612802 chr10:30756441 G/A cg25182066 chr10:30743637 MAP3K8 -0.52 -7.18 -0.37 4.68e-12 Itch intensity from mosquito bite; CRC cis rs853679 0.550 rs1237875 chr6:28173010 A/G cg12273811 chr6:28175739 NA -0.77 -11.19 -0.53 7.31e-25 Depression; CRC cis rs1153858 0.943 rs4774580 chr15:45652086 G/A cg21132104 chr15:45694354 SPATA5L1 0.6 8.82 0.44 6.64e-17 Homoarginine levels; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg10347199 chr17:7123561 DLG4;ACADVL 0.49 6.72 0.35 8.09e-11 Anxiety disorder; CRC cis rs801193 1.000 rs2707836 chr7:66160435 A/C cg18876405 chr7:65276391 NA 0.61 10.76 0.51 2.53e-23 Aortic root size; CRC cis rs6662572 0.737 rs56316933 chr1:46266725 C/T cg03123370 chr1:45965343 CCDC163P;MMACHC 0.48 5.91 0.31 8.39e-9 Blood protein levels; CRC cis rs9287719 0.967 rs7563894 chr2:10754649 A/G cg00105475 chr2:10696890 NA 0.45 7.09 0.36 8.01e-12 Prostate cancer; CRC cis rs45544231 0.569 rs9923558 chr16:52548183 A/T cg09051775 chr16:52580266 TOX3 -0.38 -6.16 -0.32 2.15e-9 Restless legs syndrome; CRC cis rs7613875 0.620 rs34312088 chr3:50032133 C/T cg24308560 chr3:49941425 MST1R -0.44 -6.81 -0.35 4.69e-11 Body mass index; CRC cis rs10782582 0.593 rs115291524 chr1:76141811 A/G cg10523679 chr1:76189770 ACADM -0.41 -5.78 -0.3 1.72e-8 Daytime sleep phenotypes; CRC cis rs763121 0.853 rs5750673 chr22:39110124 G/A cg06544989 chr22:39130855 UNC84B 0.45 6.94 0.36 2.03e-11 Menopause (age at onset); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg05007375 chr14:92588364 NDUFB1;CPSF2 0.45 7.36 0.38 1.49e-12 Liver disease severity in Alagille syndrome; CRC cis rs7666738 0.830 rs6854919 chr4:98947326 C/T cg05340658 chr4:99064831 C4orf37 0.55 8.2 0.41 5.46e-15 Colonoscopy-negative controls vs population controls; CRC cis rs8141529 0.748 rs132529 chr22:29296652 A/G cg15103426 chr22:29168792 CCDC117 -0.5 -6.86 -0.35 3.36e-11 Lymphocyte counts; CRC cis rs9916302 0.706 rs9891892 chr17:37479856 A/C cg00129232 chr17:37814104 STARD3 0.56 6.98 0.36 1.67e-11 Glomerular filtration rate (creatinine); CRC cis rs12200782 0.505 rs9295696 chr6:26550288 C/T cg09904177 chr6:26538194 HMGN4 0.57 6.76 0.35 6.47e-11 Small cell lung carcinoma; CRC cis rs72772090 0.539 rs56319744 chr5:96141938 G/C cg17330273 chr5:96107758 CAST;ERAP1 -0.62 -6.08 -0.32 3.33e-9 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs7772486 0.558 rs62435775 chr6:146136415 G/C cg05347473 chr6:146136440 FBXO30 0.5 7.22 0.37 3.59e-12 Lobe attachment (rater-scored or self-reported); CRC cis rs13108904 0.870 rs12499546 chr4:1255194 C/T cg00684032 chr4:1343700 KIAA1530 0.46 6.88 0.35 3.02e-11 Obesity-related traits; CRC cis rs10504229 0.683 rs61241336 chr8:58106585 A/G cg21724239 chr8:58056113 NA 0.52 6.99 0.36 1.58e-11 Developmental language disorder (linguistic errors); CRC cis rs8180040 0.654 rs6791062 chr3:47174343 T/A cg02527881 chr3:46936655 PTH1R -0.34 -6.02 -0.32 4.55e-9 Colorectal cancer; CRC cis rs317689 0.680 rs315140 chr12:69790780 A/T cg14784868 chr12:69753453 YEATS4 0.55 6.78 0.35 5.61e-11 Response to diuretic therapy; CRC trans rs7395662 0.963 rs11039950 chr11:48737471 G/A cg21153622 chr11:89784906 NA 0.46 7.44 0.38 8.9e-13 HDL cholesterol; CRC cis rs2013441 0.896 rs1812934 chr17:20030960 A/T cg13482628 chr17:19912719 NA -0.4 -6.06 -0.32 3.69e-9 Obesity-related traits; CRC cis rs7769051 0.711 rs9493436 chr6:133088275 T/C cg22852734 chr6:133119734 C6orf192 0.88 10.36 0.5 6.12e-22 Type 2 diabetes nephropathy; CRC cis rs7666738 0.830 rs7673385 chr4:99024922 T/G cg17366294 chr4:99064904 C4orf37 0.43 7.13 0.37 6.27e-12 Colonoscopy-negative controls vs population controls; CRC cis rs4268898 0.610 rs34216622 chr2:24463445 G/C cg06627628 chr2:24431161 ITSN2 -0.86 -11.76 -0.54 6.57e-27 Asthma; CRC cis rs870825 0.587 rs6826883 chr4:185616167 A/C cg04058563 chr4:185651563 MLF1IP 0.72 9.2 0.45 4.12e-18 Blood protein levels; CRC cis rs4363385 0.818 rs2070963 chr1:153004004 G/A cg25856811 chr1:152973957 SPRR3 -0.25 -6.94 -0.36 2.12e-11 Inflammatory skin disease; CRC cis rs12024301 0.557 rs6677194 chr1:183635587 T/C cg11505048 chr1:183622726 RGL1;APOBEC4 0.78 6.93 0.36 2.18e-11 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs10791323 0.593 rs2282604 chr11:133714672 A/G cg06766960 chr11:133703094 NA -0.36 -5.97 -0.31 6.19e-9 Childhood ear infection; CRC cis rs9400271 0.632 rs9384705 chr6:109588244 T/C cg01475377 chr6:109611718 NA -0.35 -6.09 -0.32 3.18e-9 Sum neutrophil eosinophil counts;Sum basophil neutrophil counts;White blood cell count;Neutrophil count;Myeloid white cell count;Granulocyte count; CRC cis rs6121246 0.567 rs6060263 chr20:30193110 T/C cg13852791 chr20:30311386 BCL2L1 0.6 8.21 0.41 5.04e-15 Mean corpuscular hemoglobin; CRC cis rs330048 0.525 rs10112237 chr8:9072729 A/T cg08975724 chr8:8085496 FLJ10661 -0.38 -5.71 -0.3 2.52e-8 Systemic lupus erythematosus; CRC cis rs4332037 0.615 rs62435127 chr7:1884937 A/G cg23422044 chr7:1970798 MAD1L1 -0.48 -6.22 -0.32 1.5e-9 Bipolar disorder; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg11353368 chr19:47363757 NA 0.43 6.43 0.33 4.61e-10 Response to antipsychotic treatment; CRC cis rs4363385 0.747 rs9919227 chr1:152970867 A/G cg25856811 chr1:152973957 SPRR3 -0.26 -7.24 -0.37 3.29e-12 Inflammatory skin disease; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg23376526 chr1:153748118 SLC27A3 0.42 6.3 0.33 9.31e-10 Intelligence (multi-trait analysis); CRC cis rs6479527 0.810 rs2153070 chr9:96751573 C/G cg14459158 chr9:96720562 NA 0.41 7.43 0.38 9.19e-13 Esophageal adenocarcinoma; CRC cis rs2949837 0.581 rs2960437 chr7:45977352 G/A cg10677697 chr7:45961126 IGFBP3 0.36 6.29 0.33 1.03e-9 Sitting height ratio; CRC cis rs17767392 0.794 rs61991247 chr14:71860318 C/T cg13720639 chr14:72061746 SIPA1L1 -0.54 -6.89 -0.35 2.93e-11 Mitral valve prolapse; CRC cis rs2841233 0.692 rs2028416 chr14:105348552 C/T cg03469805 chr14:105330648 KIAA0284 -0.33 -6.96 -0.36 1.89e-11 IgG glycosylation; CRC cis rs10504229 0.775 rs55734109 chr8:58162322 G/A cg22535103 chr8:58192502 C8orf71 -0.72 -8.42 -0.42 1.22e-15 Developmental language disorder (linguistic errors); CRC cis rs651907 0.535 rs1460097 chr3:101497569 C/T cg11279151 chr3:101281821 RG9MTD1 -0.51 -6.88 -0.35 3.08e-11 Colorectal cancer; CRC cis rs10540 1.000 rs71487292 chr11:486076 G/A cg03934478 chr11:495069 RNH1 0.69 7.01 0.36 1.35e-11 Body mass index; CRC cis rs62103177 0.713 rs62103186 chr18:77627574 G/C cg12964065 chr18:77638022 KCNG2 0.66 6.69 0.35 9.58e-11 Opioid sensitivity; CRC cis rs8016982 0.633 rs7160342 chr14:81713427 G/C cg01989461 chr14:81687754 GTF2A1 0.64 10.44 0.5 3.21e-22 Schizophrenia; CRC cis rs12995491 0.843 rs1878809 chr2:88518315 C/T cg07952391 chr2:88470173 THNSL2 -0.38 -5.87 -0.31 1.05e-8 Response to metformin (IC50); CRC trans rs916888 0.773 rs199533 chr17:44828931 G/A cg10053473 chr17:62856997 LRRC37A3 -0.82 -8.75 -0.43 1.15e-16 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs4713118 0.869 rs6456802 chr6:27698355 A/G cg02683197 chr6:28174875 NA 0.63 8.62 0.43 2.81e-16 Parkinson's disease; CRC cis rs7208859 0.673 rs73263785 chr17:29214808 C/T cg13385521 chr17:29058706 SUZ12P 0.68 8.02 0.4 1.83e-14 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs4077468 0.927 rs1342063 chr1:205912859 C/T cg13172432 chr1:205912842 SLC26A9 -0.34 -5.95 -0.31 6.92e-9 Cystic fibrosis-related diabetes; CRC cis rs514406 0.505 rs447581 chr1:53177098 T/C cg25767906 chr1:53392781 SCP2 -0.39 -6.1 -0.32 2.92e-9 Monocyte count; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg09103232 chr17:7185001 SLC2A4 0.44 6.09 0.32 3.23e-9 Response to antipsychotic treatment; CRC trans rs8108034 1.000 rs39587 chr19:39806997 C/T cg14903685 chr15:70391316 TLE3 -0.57 -6.4 -0.33 5.44e-10 Lung adenocarcinoma; CRC cis rs1218582 0.774 rs4845681 chr1:154868055 G/T cg24250549 chr1:154909240 PMVK 0.59 9.78 0.47 5.45e-20 Prostate cancer; CRC cis rs447 1.000 rs12707619 chr7:83748427 T/C cg22846510 chr7:83753280 SEMA3A -0.6 -7.79 -0.39 8.91e-14 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs11212617 0.935 rs183459 chr11:108089197 G/T cg14761454 chr11:108092087 ATM;NPAT 0.4 5.88 0.31 9.86e-9 Response to metformin in type 2 diabetes (glycemic); CRC cis rs11866815 0.602 rs60907769 chr16:380547 C/A cg00101154 chr16:420108 MRPL28 0.53 5.71 0.3 2.5e-8 Body mass index; CRC trans rs9329221 0.617 rs483916 chr8:9793601 A/C cg08975724 chr8:8085496 FLJ10661 -0.47 -7.63 -0.39 2.57e-13 Neuroticism; CRC cis rs2836974 0.590 rs9974757 chr21:40617244 T/C cg11644478 chr21:40555479 PSMG1 -0.7 -11.37 -0.53 1.75e-25 Cognitive function; CRC cis rs11098499 0.863 rs34308924 chr4:120481431 T/C cg24375607 chr4:120327624 NA 0.48 7.24 0.37 3.2e-12 Corneal astigmatism; CRC cis rs62064224 0.714 rs16967266 chr17:30632274 G/A cg25809561 chr17:30822961 MYO1D 0.51 9.23 0.45 3.28e-18 Schizophrenia; CRC cis rs853679 0.517 rs9380065 chr6:28144751 A/G cg06470822 chr6:28175283 NA 1.01 13.28 0.59 1.55e-32 Depression; CRC cis rs7589728 0.514 rs74426843 chr2:88459388 C/T cg14558114 chr2:88469736 THNSL2 0.62 6.22 0.32 1.48e-9 Plasma clusterin levels; CRC cis rs4731207 0.698 rs10269011 chr7:124478813 T/C cg23710748 chr7:124431027 NA 0.38 6.08 0.32 3.42e-9 Cutaneous malignant melanoma; CRC cis rs926938 0.563 rs360586 chr1:115467489 A/G cg12756093 chr1:115239321 AMPD1 0.57 8.22 0.41 4.76e-15 Autism; CRC cis rs11785400 0.793 rs7459963 chr8:143737129 C/T cg10596483 chr8:143751796 JRK 0.44 5.95 0.31 6.73e-9 Schizophrenia; CRC cis rs11997175 0.574 rs12156280 chr8:33650277 C/T cg04338863 chr8:33670619 NA 0.4 6.8 0.35 5.06e-11 Body mass index; CRC trans rs2303319 0.504 rs72877343 chr2:162607487 A/C cg22988483 chr14:93581567 ITPK1 -0.66 -6.07 -0.32 3.52e-9 Cognitive function; CRC cis rs9372498 0.536 rs62422224 chr6:118941116 G/A cg01339444 chr6:118972232 C6orf204 0.56 6.09 0.32 3.14e-9 Diastolic blood pressure; CRC cis rs45430 1.000 rs45430 chr21:42746081 C/T cg22778903 chr21:42741698 MX2 0.38 6.25 0.33 1.26e-9 Melanoma; CRC cis rs877282 0.898 rs34490091 chr10:765800 A/C cg17470449 chr10:769945 NA 0.64 8.08 0.41 1.28e-14 Uric acid levels; CRC cis rs4132509 1.000 rs28869008 chr1:243986344 C/A cg21452805 chr1:244014465 NA 0.53 7.14 0.37 5.9e-12 RR interval (heart rate); CRC cis rs4237845 0.622 rs10783859 chr12:58332794 C/A cg02175503 chr12:58329896 NA 0.76 11.83 0.55 3.9e-27 Intelligence (multi-trait analysis); CRC cis rs4909189 1.000 rs71547530 chr7:158135503 A/G cg25566285 chr7:158114605 PTPRN2 0.42 5.76 0.3 1.94e-8 Response to amphetamines; CRC trans rs6546324 0.539 rs4671192 chr2:67841855 A/G cg00907274 chr3:27498161 SLC4A7 -0.48 -6.13 -0.32 2.55e-9 Endometriosis; CRC cis rs7727544 0.716 rs4705926 chr5:131561758 C/T cg11843238 chr5:131593191 PDLIM4 0.34 6.38 0.33 5.98e-10 Blood metabolite levels; CRC cis rs9733 0.596 rs7529998 chr1:150662531 C/T cg18016565 chr1:150552671 MCL1 0.46 6.74 0.35 6.91e-11 Tonsillectomy; CRC trans rs7618501 1.000 rs11709680 chr3:49745188 C/T cg21582582 chr3:182698605 DCUN1D1 -0.56 -8.33 -0.42 2.24e-15 Intelligence (multi-trait analysis); CRC cis rs5769765 0.671 rs138832 chr22:50178082 A/G cg04121214 chr22:50244548 NA 0.45 6.31 0.33 9.27e-10 Schizophrenia; CRC cis rs4820294 0.669 rs9622677 chr22:38054262 A/C cg21798802 chr22:38057573 PDXP 0.35 5.68 0.3 2.93e-8 Fat distribution (HIV); CRC cis rs7258465 0.931 rs8107351 chr19:18612758 G/A cg10790698 chr19:18539756 SSBP4 -0.43 -8.4 -0.42 1.37e-15 Breast cancer; CRC cis rs798554 0.757 rs1182172 chr7:2878103 G/A cg04166393 chr7:2884313 GNA12 0.51 6.75 0.35 6.85e-11 Height; CRC cis rs6831352 0.918 rs35784540 chr4:100061692 T/A cg13256891 chr4:100009986 ADH5 -0.66 -8.9 -0.44 3.84e-17 Alcohol dependence; CRC cis rs13191362 1.000 rs67042566 chr6:163006541 A/T cg21926612 chr6:163149169 PACRG;PARK2 0.8 11.15 0.52 1.08e-24 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs1862618 0.853 rs252921 chr5:56137787 G/A cg18230493 chr5:56204884 C5orf35 -0.7 -9.07 -0.45 1.13e-17 Initial pursuit acceleration; CRC cis rs611744 0.647 rs11785776 chr8:109264933 C/T cg21045802 chr8:109455806 TTC35 0.41 6.53 0.34 2.55e-10 Dupuytren's disease; CRC cis rs1150668 0.796 rs2247002 chr6:28397951 G/C cg21251018 chr6:28226885 NKAPL 0.48 8.25 0.41 3.84e-15 Pubertal anthropometrics; CRC cis rs372883 0.648 rs11088117 chr21:30737816 G/C cg24692254 chr21:30365293 RNF160 0.61 9.29 0.46 2.17e-18 Pancreatic cancer; CRC cis rs9303542 0.559 rs62066693 chr17:46617530 G/C cg04904318 chr17:46607828 HOXB1 -0.53 -6.14 -0.32 2.36e-9 Ovarian cancer;Epithelial ovarian cancer; CRC cis rs9303401 0.659 rs11079357 chr17:56902778 A/G cg02118635 chr17:56770003 RAD51C;TEX14 0.78 9.95 0.48 1.51e-20 Cognitive test performance; CRC cis rs4332037 0.851 rs34040190 chr7:1920356 G/A cg25834613 chr7:1915315 MAD1L1 -0.48 -6.82 -0.35 4.38e-11 Bipolar disorder; CRC trans rs11098499 0.954 rs28572238 chr4:120316686 T/G cg25214090 chr10:38739885 LOC399744 0.65 10.23 0.49 1.69e-21 Corneal astigmatism; CRC cis rs933688 1.000 rs6452953 chr5:90723034 T/G cg02339078 chr5:90679543 LOC100129716;ARRDC3 0.89 15.17 0.64 8.49e-40 Smoking behavior; CRC cis rs6964587 1.000 rs2299240 chr7:91654618 A/G cg17063962 chr7:91808500 NA 0.83 14.82 0.63 2.03e-38 Breast cancer; CRC cis rs3617 0.539 rs9985365 chr3:52953844 A/G cg15147215 chr3:52552868 STAB1 0.43 7.05 0.36 1.09e-11 Red blood cell count;Autism spectrum disorder or schizophrenia; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg23888375 chr2:203776317 ALS2CR8;WDR12 -0.42 -6.06 -0.32 3.68e-9 Myopia (pathological); CRC cis rs10479542 0.784 rs4701132 chr5:178985270 A/G cg14820908 chr5:178986412 RUFY1 -0.41 -7.17 -0.37 4.97e-12 Lung cancer; CRC cis rs1005277 0.579 rs2021649 chr10:38392122 C/T cg00409905 chr10:38381863 ZNF37A -0.67 -11.23 -0.53 5.37e-25 Extrinsic epigenetic age acceleration; CRC cis rs6502050 0.805 rs56020943 chr17:80105248 C/A cg11859384 chr17:80120422 CCDC57 -0.37 -5.85 -0.31 1.16e-8 Life satisfaction; CRC trans rs9929218 0.953 rs3114411 chr16:68734591 G/T cg04657470 chr2:198365150 HSPE1;HSPD1 0.94 12.91 0.58 3.83e-31 Colorectal cancer; CRC cis rs9322193 0.923 rs12175504 chr6:149985215 T/G cg07701084 chr6:150067640 NUP43 0.47 6.63 0.34 1.36e-10 Lung cancer; CRC cis rs941873 0.869 rs7917610 chr10:81117237 T/C cg09469691 chr10:81107165 PPIF 0.58 9.38 0.46 1.12e-18 Height; CRC trans rs1005277 0.579 rs1985707 chr10:38434098 C/T cg27523141 chr10:43048294 ZNF37B 0.49 7.15 0.37 5.75e-12 Extrinsic epigenetic age acceleration; CRC cis rs10504229 0.906 rs56130194 chr8:58197061 C/A cg02725872 chr8:58115012 NA -0.44 -6.23 -0.32 1.45e-9 Developmental language disorder (linguistic errors); CRC cis rs6598163 0.517 rs11246827 chr12:132296423 G/A cg22244940 chr12:132335942 MMP17 0.44 6.49 0.34 3.07e-10 Migraine; CRC cis rs6582630 0.598 rs12823134 chr12:38514347 T/A cg26384229 chr12:38710491 ALG10B -0.52 -7.49 -0.38 6.57e-13 Drug-induced liver injury (flucloxacillin); CRC cis rs1862618 0.525 rs2662019 chr5:56263104 A/G cg12311346 chr5:56204834 C5orf35 0.77 10.66 0.51 5.7e-23 Initial pursuit acceleration; CRC cis rs524023 0.914 rs2666559 chr11:64439227 G/T cg06522879 chr11:64358276 SLC22A12 -0.51 -7.88 -0.4 4.91e-14 Urate levels in obese individuals; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg12670061 chr16:67465042 HSD11B2 0.43 6.01 0.31 4.95e-9 Anxiety disorder; CRC cis rs6951245 1.000 rs76804143 chr7:1082021 C/T cg03188948 chr7:1209495 NA 0.63 6.54 0.34 2.29e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs60871478 0.898 rs62432225 chr7:789433 G/A cg13844804 chr7:814759 HEATR2 0.66 7.86 0.4 5.47e-14 Cerebrospinal P-tau181p levels; CRC cis rs10504229 0.683 rs11774847 chr8:58140775 T/A cg02290350 chr8:58132656 NA -0.61 -7.12 -0.37 6.7e-12 Developmental language disorder (linguistic errors); CRC trans rs9291683 0.527 rs73212848 chr4:10093299 T/C cg26043149 chr18:55253948 FECH -0.55 -8.25 -0.41 3.76e-15 Bone mineral density; CRC cis rs6694672 1.000 rs1412640 chr1:197070815 T/C cg13682187 chr1:196946512 CFHR5 0.51 8.24 0.41 4.16e-15 Asthma; CRC cis rs6783573 0.535 rs12637699 chr3:46628443 C/T cg27371741 chr3:46619158 LRRC2;TDGF1 -0.42 -5.87 -0.31 1.06e-8 Cerebrospinal fluid biomarker levels; CRC cis rs11628318 0.715 rs1815262 chr14:103056926 C/T cg23071808 chr14:103021642 NA -0.64 -6.96 -0.36 1.84e-11 Platelet count; CRC cis rs35110281 0.782 rs1454650 chr21:45012353 C/T cg01579765 chr21:45077557 HSF2BP -0.37 -7.12 -0.37 6.61e-12 Mean corpuscular volume; CRC cis rs501120 0.584 rs10900003 chr10:44698044 C/A cg09554077 chr10:44749378 NA 0.69 7.91 0.4 4.04e-14 Coronary artery disease;Coronary heart disease; CRC cis rs2985684 0.948 rs6572592 chr14:50080871 G/A cg04989706 chr14:50066350 PPIL5 -0.6 -8.22 -0.41 4.87e-15 Carotid intima media thickness; CRC cis rs826838 0.684 rs12367400 chr12:38618673 G/T cg26384229 chr12:38710491 ALG10B 0.69 9.2 0.45 4.37e-18 Heart rate; CRC cis rs28386778 0.830 rs2665841 chr17:61861219 A/T cg06601766 chr17:61851465 DDX42;CCDC47 0.46 6.22 0.32 1.51e-9 Prudent dietary pattern; CRC cis rs6088590 0.687 rs73106933 chr20:33287425 T/C cg08999081 chr20:33150536 PIGU 0.57 10.34 0.5 6.81e-22 Coronary artery disease; CRC trans rs12188164 0.610 rs6555242 chr5:416546 A/C cg15371732 chr17:78194151 SLC26A11;SGSH 0.42 6.26 0.33 1.18e-9 Cystic fibrosis severity; CRC cis rs3892630 0.878 rs1061686 chr19:33204544 C/T cg22980127 chr19:33182716 NUDT19 -0.82 -10.22 -0.49 1.74e-21 Red blood cell traits; CRC cis rs10540 0.730 rs34690033 chr11:492677 G/C cg03576123 chr11:487126 PTDSS2 -1.03 -10.72 -0.51 3.43e-23 Body mass index; CRC cis rs868036 0.918 rs4238411 chr15:68079424 A/T cg05925327 chr15:68127851 NA -0.32 -6.15 -0.32 2.22e-9 Restless legs syndrome; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg14431266 chr11:67057003 ANKRD13D 0.49 7.05 0.36 1.05e-11 Response to antipsychotic treatment; CRC cis rs4665809 1.000 rs6546744 chr2:26302161 A/G cg27170947 chr2:26402098 FAM59B -0.45 -6.03 -0.32 4.51e-9 Gut microbiome composition (summer); CRC cis rs561341 1.000 rs111454793 chr17:30319267 T/C cg12193833 chr17:30244370 NA -0.76 -8.87 -0.44 4.62e-17 Hip circumference adjusted for BMI; CRC cis rs972578 1.000 rs2256040 chr22:43398049 C/A cg01576275 chr22:43409880 NA -0.48 -7.92 -0.4 3.65e-14 Mean platelet volume; CRC cis rs2228479 0.850 rs9282681 chr16:89805914 T/C cg06558623 chr16:89946397 TCF25 1.16 10.86 0.51 1.1e-23 Skin colour saturation; CRC cis rs11122272 0.701 rs7414807 chr1:231476874 G/A cg06096015 chr1:231504339 EGLN1 0.38 5.7 0.3 2.67e-8 Hemoglobin concentration; CRC cis rs12701220 0.894 rs12701406 chr7:1050283 G/A cg26240231 chr7:1148101 C7orf50 -0.42 -5.7 -0.3 2.61e-8 Bronchopulmonary dysplasia; CRC cis rs4713118 0.955 rs9368528 chr6:27683798 G/A cg12172441 chr6:28176163 NA 0.47 6.19 0.32 1.75e-9 Parkinson's disease; CRC cis rs1348850 0.567 rs4893838 chr2:178531436 T/C cg22681709 chr2:178499509 PDE11A -0.43 -7.92 -0.4 3.58e-14 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs9733 0.818 rs4970924 chr1:150633079 A/G cg17724175 chr1:150552817 MCL1 -0.46 -7.22 -0.37 3.54e-12 Tonsillectomy; CRC cis rs780096 0.546 rs1060525 chr2:27635582 A/G cg24768116 chr2:27665128 KRTCAP3 -0.33 -7.37 -0.38 1.37e-12 Total body bone mineral density; CRC cis rs270601 0.770 rs1007602 chr5:131602166 T/C cg11843238 chr5:131593191 PDLIM4 0.49 9.31 0.46 1.86e-18 Acylcarnitine levels; CRC cis rs12497850 0.931 rs9311432 chr3:48850443 T/A cg20833759 chr3:49053208 WDR6;DALRD3 0.53 9.22 0.45 3.73e-18 Parkinson's disease; CRC cis rs9926296 0.572 rs2376878 chr16:89885161 G/A cg27121462 chr16:89883253 FANCA 0.44 6.92 0.36 2.38e-11 Vitiligo; CRC cis rs875971 1.000 rs2220626 chr7:65546062 C/T cg18876405 chr7:65276391 NA -0.52 -9.04 -0.45 1.36e-17 Aortic root size; CRC cis rs6502050 0.805 rs4789740 chr17:80119202 T/C cg19223190 chr17:80058835 NA 0.39 6.17 0.32 2.02e-9 Life satisfaction; CRC trans rs208520 0.690 rs12194057 chr6:66745616 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 1.05 14.83 0.63 1.81e-38 Exhaled nitric oxide output; CRC cis rs10463316 0.817 rs58892766 chr5:150776115 T/C cg03212797 chr5:150827313 SLC36A1 -0.45 -6.93 -0.36 2.25e-11 Metabolite levels (Pyroglutamine); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg12235988 chr19:1605645 UQCR 0.38 5.96 0.31 6.39e-9 Liver disease severity in Alagille syndrome; CRC cis rs6860806 0.507 rs169256 chr5:131688533 A/G cg04518342 chr5:131593106 PDLIM4 0.42 6.02 0.32 4.62e-9 Breast cancer; CRC cis rs763014 0.932 rs2384974 chr16:651279 C/G cg03804128 chr16:635623 NA 0.31 7.29 0.37 2.36e-12 Height; CRC cis rs9372498 0.536 rs9489433 chr6:118867006 G/A cg07617317 chr6:118971624 C6orf204 0.5 6.21 0.32 1.56e-9 Diastolic blood pressure; CRC cis rs7618915 0.501 rs3755798 chr3:52741160 G/A cg05573699 chr3:52720067 GNL3;PBRM1 -0.47 -6.88 -0.35 3.04e-11 Bipolar disorder; CRC cis rs832540 0.898 rs252888 chr5:56227326 T/A cg20203395 chr5:56204925 C5orf35 -0.42 -5.93 -0.31 7.8e-9 Coronary artery disease; CRC cis rs728616 0.867 rs12781912 chr10:81918128 G/T cg05935833 chr10:81318306 SFTPA2 -0.5 -5.98 -0.31 5.7e-9 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs17384381 0.953 rs3768223 chr1:85809183 T/C cg16011679 chr1:85725395 C1orf52 0.66 6.72 0.35 7.79e-11 Lobe attachment (rater-scored or self-reported); CRC cis rs2976388 0.566 rs2585141 chr8:143806343 G/A cg24634471 chr8:143751801 JRK -0.46 -6.44 -0.33 4.22e-10 Urinary tract infection frequency; CRC cis rs4713118 0.621 rs10484403 chr6:28033523 A/G cg02683197 chr6:28174875 NA 0.73 8.97 0.44 2.34e-17 Parkinson's disease; CRC cis rs765787 0.530 rs1648285 chr15:45517505 C/G cg24006582 chr15:45444508 DUOX1 -0.55 -8.37 -0.42 1.67e-15 Uric acid levels; CRC cis rs9875589 0.509 rs6442423 chr3:14016062 G/A cg14375111 chr3:14165186 TMEM43;CHCHD4 0.41 5.93 0.31 7.66e-9 Ovarian reserve; CRC cis rs9393692 0.620 rs6930616 chr6:26331969 A/G cg00631329 chr6:26305371 NA -0.56 -9.46 -0.46 6.13e-19 Educational attainment; CRC cis rs10256972 0.577 rs4999286 chr7:1199506 C/G cg09177884 chr7:1199841 ZFAND2A -0.49 -7.32 -0.37 1.88e-12 Longevity;Endometriosis; CRC cis rs4285028 0.699 rs12637968 chr3:121599976 C/T cg11130432 chr3:121712080 ILDR1 -0.48 -5.95 -0.31 6.91e-9 Multiple sclerosis; CRC trans rs7395662 1.000 rs10838944 chr11:48559571 T/C cg21153622 chr11:89784906 NA -0.45 -7.22 -0.37 3.51e-12 HDL cholesterol; CRC trans rs877282 0.853 rs7092805 chr10:756246 G/A cg22713356 chr15:30763199 NA 1.22 14.43 0.62 6.46e-37 Uric acid levels; CRC cis rs28386778 0.897 rs716880 chr17:61902822 C/G cg25654072 chr17:61904446 PSMC5;FTSJ3 0.72 11.25 0.53 4.67e-25 Prudent dietary pattern; CRC cis rs7937682 0.883 rs568038 chr11:111432161 A/C cg09085632 chr11:111637200 PPP2R1B 0.95 17.6 0.7 2.44e-49 Primary sclerosing cholangitis; CRC cis rs138880 0.542 rs9616393 chr22:50314809 A/G cg02269571 chr22:50332266 NA 0.85 9.16 0.45 5.85e-18 Schizophrenia; CRC trans rs3942852 0.806 rs1503188 chr11:48117478 C/T cg15704280 chr7:45808275 SEPT13 -0.6 -7.77 -0.39 9.9e-14 Acute lymphoblastic leukemia (childhood); CRC cis rs4144743 0.702 rs16941733 chr17:45318289 T/C cg18085866 chr17:45331354 ITGB3 -0.53 -6.12 -0.32 2.66e-9 Body mass index; CRC cis rs9811920 0.809 rs7649349 chr3:99725629 A/G cg07805332 chr3:99536008 MIR548G;C3orf26 0.39 6.0 0.31 5.28e-9 Axial length; CRC cis rs7589728 1.000 rs6720809 chr2:88528943 T/C cg07952391 chr2:88470173 THNSL2 0.64 6.34 0.33 7.37e-10 Plasma clusterin levels; CRC cis rs875971 0.862 rs4718330 chr7:65715243 G/A cg11764359 chr7:65958608 NA -0.61 -9.34 -0.46 1.54e-18 Aortic root size; CRC cis rs4774899 0.752 rs2464429 chr15:57348302 C/T cg08128148 chr15:57256372 TCF12 -0.39 -5.66 -0.3 3.33e-8 Urinary tract infection frequency; CRC cis rs12188164 0.931 rs115554641 chr5:443236 C/G cg26850624 chr5:429559 AHRR -0.8 -13.54 -0.6 1.64e-33 Cystic fibrosis severity; CRC cis rs1707322 0.964 rs1707339 chr1:46513179 A/G cg03146154 chr1:46216737 IPP -0.51 -7.09 -0.36 8.16e-12 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC trans rs7824557 0.713 rs6601575 chr8:11097804 A/C cg16141378 chr3:129829833 LOC729375 -0.46 -6.82 -0.35 4.44e-11 Retinal vascular caliber; CRC cis rs13108904 0.935 rs13148614 chr4:1248357 G/C cg24560729 chr4:1342394 KIAA1530 0.33 5.74 0.3 2.11e-8 Obesity-related traits; CRC cis rs7833790 0.963 rs10958046 chr8:82729210 A/G cg17211192 chr8:82754475 SNX16 -0.55 -6.7 -0.35 8.84e-11 Diastolic blood pressure; CRC cis rs950169 0.580 rs2271431 chr15:85189464 A/C cg17507749 chr15:85114479 UBE2QP1 0.62 8.91 0.44 3.58e-17 Schizophrenia; CRC cis rs12497850 1.000 rs4858828 chr3:48724811 C/T cg07636037 chr3:49044803 WDR6 0.92 15.86 0.66 1.86e-42 Parkinson's disease; CRC cis rs11098499 0.820 rs12503082 chr4:120284317 A/G cg09307838 chr4:120376055 NA 0.68 10.53 0.5 1.51e-22 Corneal astigmatism; CRC trans rs3942852 0.524 rs7118665 chr11:48078427 C/A cg15704280 chr7:45808275 SEPT13 0.65 9.12 0.45 7.62e-18 Acute lymphoblastic leukemia (childhood); CRC cis rs7635838 0.718 rs2594981 chr3:11380638 C/G cg00170343 chr3:11313890 ATG7 0.46 7.07 0.36 9.55e-12 HDL cholesterol; CRC cis rs6960043 0.738 rs12538043 chr7:15058998 C/G cg19272540 chr7:15055459 NA 0.23 6.22 0.32 1.55e-9 Type 2 diabetes; CRC cis rs2249694 0.520 rs7096321 chr10:135324536 A/G cg20169779 chr10:135381914 SYCE1 -0.54 -7.33 -0.37 1.76e-12 Obesity-related traits; CRC cis rs751728 0.648 rs6922275 chr6:33749739 G/A cg25922239 chr6:33757077 LEMD2 0.46 6.82 0.35 4.29e-11 Crohn's disease; CRC cis rs394563 0.591 rs11155641 chr6:149648595 G/A cg16235748 chr6:149772707 ZC3H12D 0.37 6.56 0.34 2.13e-10 Dupuytren's disease; CRC cis rs769267 0.965 rs2074303 chr19:19381755 C/T cg20644253 chr19:19431407 KIAA0892;SF4 0.43 5.97 0.31 6e-9 Tonsillectomy; CRC cis rs796364 0.760 rs11690371 chr2:200989616 A/G cg25936922 chr2:200820526 C2orf60;C2orf47 -0.66 -6.21 -0.32 1.62e-9 Schizophrenia; CRC cis rs1046896 0.553 rs56775875 chr17:80831291 G/T cg08200770 chr17:80723486 TBCD -0.5 -7.6 -0.39 3.09e-13 Glycated hemoglobin levels; CRC cis rs8058578 0.832 rs7500719 chr16:30840877 C/T cg02466173 chr16:30829666 NA -0.86 -13.84 -0.61 1.15e-34 Multiple myeloma; CRC cis rs2075371 0.932 rs2598290 chr7:133987736 C/G cg11752832 chr7:134001865 SLC35B4 0.5 7.71 0.39 1.54e-13 Mean platelet volume; CRC cis rs972578 1.000 rs5759080 chr22:43393940 C/T cg01576275 chr22:43409880 NA -0.49 -7.88 -0.4 4.74e-14 Mean platelet volume; CRC cis rs294883 0.701 rs4709293 chr6:159730481 A/G cg14500486 chr6:159655392 FNDC1 -0.36 -6.19 -0.32 1.81e-9 Coronary artery disease; CRC cis rs10992471 0.528 rs6479423 chr9:95265580 A/T cg14631576 chr9:95140430 CENPP -0.32 -5.83 -0.31 1.34e-8 Visceral adipose tissue/subcutaneous adipose tissue ratio; CRC cis rs4481887 0.861 rs6669290 chr1:248476804 G/A cg00666640 chr1:248458726 OR2T12 0.46 7.73 0.39 1.3e-13 Common traits (Other); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg26823989 chr1:87380673 SEP15;HS2ST1 0.4 7.04 0.36 1.14e-11 Liver disease severity in Alagille syndrome; CRC cis rs9733 0.596 rs6692960 chr1:150695965 G/A cg10589385 chr1:150898437 SETDB1 0.28 5.96 0.31 6.66e-9 Tonsillectomy; CRC cis rs7312933 0.567 rs11181399 chr12:42666412 G/A cg11827402 chr12:42719852 PPHLN1;ZCRB1 0.64 9.04 0.45 1.33e-17 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CRC cis rs897984 0.542 rs11864839 chr16:31095251 G/C cg02466173 chr16:30829666 NA -0.62 -9.57 -0.47 2.72e-19 Dementia with Lewy bodies; CRC cis rs737008 0.922 rs2070923 chr16:11369855 G/T cg00044050 chr16:11439710 C16orf75 0.44 5.61 0.3 4.38e-8 Obesity-related traits; CRC cis rs1223397 1.000 rs1223403 chr6:13271812 G/A cg21538684 chr6:13274180 PHACTR1 0.49 6.02 0.31 4.69e-9 Blood pressure; CRC cis rs477692 1.000 rs567700 chr10:131423126 C/T cg05714579 chr10:131428358 MGMT 0.55 8.13 0.41 8.91e-15 Response to temozolomide; CRC cis rs9381040 0.655 rs2268192 chr6:41024626 T/C cg09580153 chr6:41068724 NFYA;LOC221442 -0.42 -6.12 -0.32 2.71e-9 Alzheimer's disease (late onset); CRC cis rs1552244 1.000 rs17032268 chr3:10067972 C/T cg00166722 chr3:10149974 C3orf24 0.65 8.86 0.44 5.13e-17 Alzheimer's disease; CRC cis rs4253772 0.550 rs6007823 chr22:46706249 C/T cg24881330 chr22:46731750 TRMU 0.56 6.36 0.33 6.84e-10 LDL cholesterol;Cholesterol, total; CRC cis rs11122272 0.735 rs973253 chr1:231520874 C/T cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.54 -8.14 -0.41 7.99e-15 Hemoglobin concentration; CRC cis rs7635838 0.819 rs4684781 chr3:11516299 G/A cg00170343 chr3:11313890 ATG7 0.43 6.53 0.34 2.53e-10 HDL cholesterol; CRC cis rs6951245 1.000 rs11770909 chr7:1086716 G/A cg20603222 chr7:1096387 C7orf50;GPR146 -0.73 -8.53 -0.43 5.27e-16 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs7618501 0.573 rs7634917 chr3:50049299 T/G cg24110177 chr3:50126178 RBM5 0.47 7.02 0.36 1.25e-11 Intelligence (multi-trait analysis); CRC cis rs644799 1.000 rs481630 chr11:95582447 G/C cg25622487 chr11:95524042 FAM76B;CEP57 0.75 11.78 0.54 5.78e-27 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs1552244 1.000 rs6442147 chr3:10078247 A/G cg13047869 chr3:10149882 C3orf24 0.52 7.36 0.38 1.48e-12 Alzheimer's disease; CRC cis rs1448094 0.556 rs4897831 chr12:86168248 C/T cg02569458 chr12:86230093 RASSF9 0.49 8.05 0.41 1.48e-14 Major depressive disorder; CRC cis rs6502050 0.835 rs9674648 chr17:80096756 A/G cg25804541 chr17:80189381 SLC16A3 -0.29 -5.63 -0.3 3.8e-8 Life satisfaction; CRC cis rs4638749 0.677 rs2219081 chr2:108844350 T/C cg25838818 chr2:108905173 SULT1C2 -0.34 -5.72 -0.3 2.33e-8 Blood pressure; CRC cis rs7412746 0.658 rs3843843 chr1:150918084 C/T cg15448220 chr1:150897856 SETDB1 0.55 8.16 0.41 7.36e-15 Melanoma; CRC cis rs2398893 0.855 rs11791859 chr9:96788758 G/A cg14459158 chr9:96720562 NA 0.39 6.4 0.33 5.5e-10 Waist-hip ratio;Waist-to-hip ratio adjusted for body mass index; CRC cis rs6460942 0.915 rs6965564 chr7:12306013 C/T cg06484146 chr7:12443880 VWDE -0.54 -7.02 -0.36 1.28e-11 Coronary artery disease; CRC cis rs672059 1.000 rs483783 chr1:183162152 G/T ch.1.3577855R chr1:183094577 LAMC1 0.49 6.93 0.36 2.2e-11 Hypertriglyceridemia; CRC trans rs4332037 0.539 rs55993248 chr7:2071132 A/G cg11693508 chr17:37793320 STARD3 0.62 7.32 0.37 1.88e-12 Bipolar disorder; CRC cis rs7647973 1.000 rs73088137 chr3:49448423 G/A cg20833759 chr3:49053208 WDR6;DALRD3 -0.62 -9.27 -0.46 2.46e-18 Menarche (age at onset); CRC trans rs11039798 0.858 rs7121333 chr11:48332138 C/T cg03929089 chr4:120376271 NA 0.67 6.42 0.33 4.68e-10 Axial length; CRC cis rs9611565 0.592 rs4822046 chr22:41987543 G/A cg06481639 chr22:41940642 POLR3H -0.56 -6.03 -0.32 4.48e-9 Vitiligo; CRC cis rs4819052 0.851 rs2330011 chr21:46658498 G/A cg11663144 chr21:46675770 NA -0.73 -12.16 -0.56 2.29e-28 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs561341 0.700 rs79272796 chr17:30226974 T/C cg13647721 chr17:30228624 UTP6 0.63 8.05 0.41 1.53e-14 Hip circumference adjusted for BMI; CRC cis rs9649213 0.574 rs12873 chr7:97922773 T/C cg21770322 chr7:97807741 LMTK2 0.54 9.11 0.45 8.51e-18 Prostate cancer (SNP x SNP interaction); CRC cis rs6665290 0.904 rs3738729 chr1:227191227 C/T cg10327440 chr1:227177885 CDC42BPA -1.04 -23.0 -0.79 1.81e-70 Myeloid white cell count; CRC cis rs2303759 0.626 rs12982246 chr19:49801169 A/G cg24324837 chr19:49891574 CCDC155 0.5 6.64 0.34 1.28e-10 Multiple sclerosis; CRC trans rs2727020 0.533 rs10839195 chr11:48973460 C/T cg03929089 chr4:120376271 NA -0.49 -7.08 -0.36 8.76e-12 Coronary artery disease; CRC cis rs6582630 0.502 rs4385963 chr12:38295264 G/A cg26384229 chr12:38710491 ALG10B 0.69 9.79 0.47 5.01e-20 Drug-induced liver injury (flucloxacillin); CRC cis rs1448094 0.511 rs61930581 chr12:86157241 G/A cg06740227 chr12:86229804 RASSF9 0.38 5.7 0.3 2.73e-8 Major depressive disorder; CRC cis rs736408 0.509 rs3774349 chr3:52722335 A/C cg07507251 chr3:52567010 NT5DC2 0.45 6.81 0.35 4.52e-11 Bipolar disorder; CRC cis rs7493 0.950 rs17880101 chr7:95031457 A/T cg01874867 chr7:94954059 PON1 -0.51 -6.33 -0.33 7.86e-10 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs8016982 0.633 rs8019108 chr14:81716781 A/T cg01989461 chr14:81687754 GTF2A1 0.63 10.37 0.5 5.44e-22 Schizophrenia; CRC cis rs12612619 0.704 rs10185736 chr2:27321224 T/C cg00617064 chr2:27272375 NA 0.41 6.61 0.34 1.59e-10 Venous thromboembolism adjusted for sickle cell variant rs77121243-T; CRC cis rs11148252 0.740 rs9536046 chr13:52955899 T/G cg12458913 chr13:53173898 NA 0.49 7.19 0.37 4.52e-12 Lewy body disease; CRC cis rs699 0.698 rs2478528 chr1:230863396 T/C cg07502417 chr1:230849801 AGT 0.29 5.94 0.31 7.11e-9 Coronary artery disease; CRC cis rs9818758 0.607 rs10049462 chr3:49309684 C/T cg07636037 chr3:49044803 WDR6 -0.72 -6.08 -0.32 3.38e-9 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; CRC cis rs2991971 0.934 rs11580609 chr1:45975856 C/G cg03123370 chr1:45965343 CCDC163P;MMACHC -0.4 -6.17 -0.32 1.95e-9 High light scatter reticulocyte count; CRC cis rs295140 0.507 rs4673814 chr2:201108133 G/A cg23649088 chr2:200775458 C2orf69 -0.43 -6.26 -0.33 1.17e-9 QT interval; CRC cis rs597539 0.652 rs654071 chr11:68653432 A/C cg06028808 chr11:68637592 NA 0.4 6.34 0.33 7.42e-10 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC trans rs931812 0.757 rs34988706 chr8:101907062 C/T cg20993868 chr7:22813445 NA 0.45 9.01 0.44 1.68e-17 Attention deficit hyperactivity disorder and conduct disorder; CRC cis rs2108225 0.967 rs7785790 chr7:107449896 C/T cg18560240 chr7:107437656 SLC26A3 0.56 8.52 0.43 5.68e-16 Ulcerative colitis; CRC cis rs11098499 0.644 rs10012252 chr4:120559139 T/C cg09307838 chr4:120376055 NA 0.62 9.54 0.47 3.25e-19 Corneal astigmatism; CRC cis rs6867032 0.570 rs13166888 chr5:1982966 G/T cg26168224 chr5:2018326 NA -0.8 -11.4 -0.53 1.35e-25 Gut microbiome composition (winter); CRC cis rs1448094 0.512 rs6539933 chr12:86247611 T/C cg25456477 chr12:86230367 RASSF9 0.34 6.01 0.31 4.96e-9 Major depressive disorder; CRC cis rs7692995 1.000 rs7659195 chr4:18022692 T/C cg08925142 chr4:18023851 LCORL -0.51 -5.81 -0.3 1.5e-8 Height; CRC cis rs9549367 0.774 rs9549364 chr13:113903745 T/C cg00898013 chr13:113819073 PROZ -0.46 -6.51 -0.34 2.77e-10 Platelet distribution width; CRC cis rs815815 0.608 rs6751198 chr2:47396274 C/T cg27223769 chr2:47403360 CALM2 -0.6 -7.79 -0.39 8.81e-14 Dialysis-related mortality; CRC cis rs7274811 0.681 rs291670 chr20:31945861 G/A cg07470512 chr20:32255052 NECAB3;C20orf134 0.42 5.83 0.31 1.32e-8 Height; CRC cis rs2243480 1.000 rs778679 chr7:65840911 A/G cg12463550 chr7:65579703 CRCP 0.7 6.26 0.33 1.22e-9 Diabetic kidney disease; CRC trans rs2018683 0.739 rs10233884 chr7:28972307 A/G cg19402173 chr7:128379420 CALU -0.42 -6.15 -0.32 2.25e-9 Response to irinotecan and platinum-based chemotherapy in non-small-cell lung cancer; CRC cis rs733592 0.599 rs12819124 chr12:48409054 G/T cg21466736 chr12:48725269 NA -0.43 -6.75 -0.35 6.5e-11 Plateletcrit; CRC cis rs9488822 0.676 rs13210143 chr6:116389636 G/A cg26893134 chr6:116381904 FRK 0.26 7.63 0.39 2.57e-13 Cholesterol, total;LDL cholesterol; CRC cis rs1223397 0.651 rs2439543 chr6:13312153 A/C cg07912922 chr6:13274314 PHACTR1 0.38 6.0 0.31 5.21e-9 Blood pressure; CRC cis rs8180040 0.966 rs11719877 chr3:47425473 C/T cg27129171 chr3:47204927 SETD2 0.52 8.07 0.41 1.37e-14 Colorectal cancer; CRC trans rs75804782 0.810 rs55694368 chr2:239317692 G/T cg01134436 chr17:81009848 B3GNTL1 0.72 6.43 0.33 4.4e-10 Morning vs. evening chronotype;Chronotype; CRC cis rs300703 0.654 rs300771 chr2:117241 A/G cg21211680 chr2:198530 NA -1.0 -11.73 -0.54 9.05e-27 Blood protein levels; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg17474435 chr12:50135167 TMBIM6 0.53 6.78 0.35 5.52e-11 Thyroid stimulating hormone; CRC cis rs7959452 0.503 rs7300266 chr12:69654187 A/G cg20891283 chr12:69753455 YEATS4 0.76 12.86 0.58 6.25e-31 Blood protein levels; CRC cis rs1865760 0.566 rs3752420 chr6:26027135 G/A cg17691542 chr6:26056736 HIST1H1C 0.55 8.32 0.42 2.36e-15 Height; CRC cis rs2075671 0.855 rs62483567 chr7:100286435 G/A cg16850897 chr7:100343110 ZAN -0.59 -8.78 -0.44 9.43e-17 Other erythrocyte phenotypes; CRC cis rs6495122 0.699 rs1378942 chr15:75077367 A/C cg14664628 chr15:75095509 CSK 0.71 11.64 0.54 1.92e-26 Caffeine consumption;Diastolic blood pressure;Coffee consumption; CRC cis rs637571 0.676 rs1151523 chr11:65665200 C/T cg04055107 chr11:65626734 MUS81;CFL1 -0.43 -6.04 -0.32 4.08e-9 Eosinophil percentage of white cells; CRC cis rs4713118 0.513 rs156739 chr6:28013410 C/A cg21251018 chr6:28226885 NKAPL 0.47 7.36 0.38 1.49e-12 Parkinson's disease; CRC cis rs3889199 0.924 rs12758643 chr1:59669918 C/T cg25881383 chr1:59680599 NA -0.38 -6.08 -0.32 3.36e-9 Pulse pressure; CRC trans rs2727020 0.576 rs12293522 chr11:49558425 T/A cg11707556 chr5:10655725 ANKRD33B -0.4 -7.6 -0.39 3.02e-13 Coronary artery disease; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg23699148 chr19:53087184 ZNF701 -0.39 -6.51 -0.34 2.78e-10 Liver disease severity in Alagille syndrome; CRC cis rs2976388 0.578 rs3736010 chr8:143817503 T/C cg04969067 chr8:143858791 LYNX1 -0.42 -6.2 -0.32 1.7e-9 Urinary tract infection frequency; CRC cis rs4072980 0.527 rs11210825 chr1:38446986 G/A cg04673462 chr1:38461896 NA 0.36 5.87 0.31 1.07e-8 Coronary artery disease; CRC cis rs362272 0.545 rs3129308 chr4:3309272 C/T cg02993699 chr4:3415135 RGS12 -0.38 -6.32 -0.33 8.43e-10 Serum sulfate level; CRC cis rs13108904 0.901 rs7668661 chr4:1300172 A/G cg20887711 chr4:1340912 KIAA1530 0.43 6.47 0.34 3.61e-10 Obesity-related traits; CRC cis rs910316 0.726 rs175040 chr14:75469555 A/G cg11812906 chr14:75593930 NEK9 -0.57 -8.73 -0.43 1.29e-16 Height; CRC cis rs28386778 0.734 rs12946669 chr17:62006007 A/G cg06873352 chr17:61820015 STRADA 0.54 9.18 0.45 4.86e-18 Prudent dietary pattern; CRC cis rs8180040 0.966 rs60369822 chr3:47479735 A/C cg27129171 chr3:47204927 SETD2 -0.59 -9.14 -0.45 6.57e-18 Colorectal cancer; CRC cis rs1707322 0.716 rs6694889 chr1:46101806 A/C cg06784218 chr1:46089804 CCDC17 0.65 12.37 0.56 3.93e-29 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs3751196 0.901 rs77409472 chr12:104181616 C/T cg02344784 chr12:104178138 NT5DC3 0.69 7.01 0.36 1.4e-11 Sense of smell; CRC trans rs2303319 0.504 rs62188153 chr2:162313036 G/T cg04145477 chr6:107077629 RTN4IP1;QRSL1 -0.84 -6.27 -0.33 1.13e-9 Cognitive function; CRC cis rs9393692 0.875 rs2142703 chr6:26289605 A/G cg13736514 chr6:26305472 NA -0.62 -11.66 -0.54 1.56e-26 Educational attainment; CRC cis rs9287719 0.746 rs6742448 chr2:10759126 G/A cg00105475 chr2:10696890 NA 0.45 7.12 0.37 6.81e-12 Prostate cancer; CRC cis rs13315871 1.000 rs13320620 chr3:58408845 A/G cg20936604 chr3:58311152 NA -0.75 -7.12 -0.37 6.99e-12 Cholesterol, total; CRC trans rs7615952 0.546 rs11711150 chr3:125315663 C/T cg02007433 chr3:129722099 NA -0.51 -6.13 -0.32 2.54e-9 Blood pressure (smoking interaction); CRC cis rs9640161 0.659 rs7781827 chr7:150008858 T/C cg13722127 chr7:150037890 RARRES2 0.47 7.82 0.4 7.37e-14 Blood protein levels;Circulating chemerin levels; CRC cis rs28386778 0.897 rs2584626 chr17:61903179 A/G cg11494091 chr17:61959527 GH2 0.6 10.1 0.49 4.51e-21 Prudent dietary pattern; CRC cis rs270601 0.770 rs61352298 chr5:131600589 G/C cg09877947 chr5:131593287 PDLIM4 0.53 9.92 0.48 1.81e-20 Acylcarnitine levels; CRC cis rs10876993 0.890 rs1092472 chr12:58036688 G/T cg15848620 chr12:58087721 OS9 -0.6 -8.15 -0.41 7.76e-15 Celiac disease or Rheumatoid arthritis; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg23556923 chr17:62774590 LOC146880 0.26 6.52 0.34 2.72e-10 Liver disease severity in Alagille syndrome; CRC cis rs9682041 0.597 rs62295834 chr3:170075701 G/A cg11886554 chr3:170076028 SKIL 0.63 7.79 0.39 8.99e-14 Glomerular filtration rate in non diabetics (creatinine);Glomerular filtration rate (creatinine); CRC cis rs1983170 1.000 rs10874785 chr1:92015243 G/A cg21854759 chr1:92012499 NA 0.46 6.17 0.32 1.98e-9 Eosinophil percentage of white cells; CRC cis rs875971 0.522 rs781144 chr7:65440344 C/G cg18876405 chr7:65276391 NA 0.68 12.75 0.57 1.63e-30 Aortic root size; CRC cis rs67311347 1.000 rs2276871 chr3:40499273 C/T cg09455208 chr3:40491958 NA 0.44 8.96 0.44 2.51e-17 Renal cell carcinoma; CRC cis rs4332037 0.615 rs62435127 chr7:1884937 A/G cg23378565 chr7:2036160 MAD1L1 -0.41 -6.27 -0.33 1.13e-9 Bipolar disorder; CRC cis rs79349575 0.811 rs60708039 chr17:46999373 C/G cg22482690 chr17:47019901 SNF8 0.48 8.07 0.41 1.33e-14 Type 2 diabetes; CRC cis rs2439831 0.764 rs2447193 chr15:43929733 A/C cg02155558 chr15:43621948 ADAL;LCMT2 0.67 7.51 0.38 5.79e-13 Lung cancer in ever smokers; CRC cis rs1561198 0.523 rs2040349 chr2:85889525 A/C cg02493740 chr2:85810744 VAMP5 -0.39 -5.92 -0.31 8.25e-9 Coronary artery disease; CRC cis rs4282054 0.631 rs13081155 chr3:52732429 A/G cg18404041 chr3:52824283 ITIH1 -0.3 -6.09 -0.32 3.08e-9 Cognitive function; CRC cis rs7103648 0.897 rs3758675 chr11:47400602 G/A cg20307385 chr11:47447363 PSMC3 0.92 14.82 0.63 2.04e-38 Diastolic blood pressure;Systolic blood pressure; CRC cis rs10504229 0.683 rs11775506 chr8:58133639 G/T cg21724239 chr8:58056113 NA 0.48 6.57 0.34 1.92e-10 Developmental language disorder (linguistic errors); CRC cis rs172166 0.694 rs536704 chr6:28092603 T/G cg12273811 chr6:28175739 NA 0.58 8.52 0.43 5.75e-16 Cardiac Troponin-T levels; CRC cis rs6496667 0.642 rs58328011 chr15:91057629 C/A cg04176472 chr15:90893244 GABARAPL3 0.55 7.94 0.4 3.16e-14 Rheumatoid arthritis; CRC cis rs10927875 0.662 rs848309 chr1:16308447 T/C cg22431228 chr1:16359049 CLCNKA -0.3 -5.63 -0.3 3.86e-8 Dilated cardiomyopathy; CRC cis rs870825 0.616 rs1401361 chr4:185643742 G/C cg04058563 chr4:185651563 MLF1IP 0.72 9.42 0.46 8.15e-19 Blood protein levels; CRC cis rs2004318 1.000 rs73614626 chr19:55139399 T/C cg03320607 chr19:54800032 LILRA3 -0.75 -6.0 -0.31 5.26e-9 Blood protein levels; CRC cis rs762407 0.925 rs4594536 chr21:45164854 C/T cg19815989 chr21:45161359 PDXK -0.39 -5.63 -0.3 3.94e-8 Systolic blood pressure change trajectories; CRC cis rs977987 0.778 rs62059846 chr16:75430809 T/A cg03315344 chr16:75512273 CHST6 0.54 9.16 0.45 5.87e-18 Dupuytren's disease; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg14023449 chr19:44342834 ZNF283 0.41 6.15 0.32 2.29e-9 Liver disease severity in Alagille syndrome; CRC cis rs10128251 0.962 rs4748018 chr10:5711507 T/A cg11519256 chr10:5708881 ASB13 0.49 6.09 0.32 3.07e-9 Childhood ear infection; CRC cis rs12200560 0.505 rs1334318 chr6:97079610 A/G cg06623918 chr6:96969491 KIAA0776 -0.51 -7.59 -0.39 3.24e-13 Coronary heart disease; CRC cis rs60871478 1.000 rs60871478 chr7:827325 A/G cg04727924 chr7:799746 HEATR2 -0.44 -6.56 -0.34 2.15e-10 Cerebrospinal P-tau181p levels; CRC cis rs13064411 0.696 rs3732803 chr3:113211957 T/C cg10517650 chr3:113235015 CCDC52 -0.4 -6.97 -0.36 1.73e-11 Response to simvastatin treatment (PCSK9 protein level change); CRC cis rs2495707 0.647 rs1541266 chr10:102421292 C/T cg03932441 chr10:102415297 NA -0.33 -5.66 -0.3 3.31e-8 Body mass index; CRC cis rs7647973 0.593 rs1799844 chr3:49847642 G/A cg03060546 chr3:49711283 APEH -0.63 -7.22 -0.37 3.71e-12 Menarche (age at onset); CRC cis rs11997175 0.713 rs4733455 chr8:33651290 C/T ch.8.33884649F chr8:33765107 NA -0.43 -6.94 -0.36 2.13e-11 Body mass index; CRC cis rs116095464 0.510 rs60844864 chr5:267000 A/G cg22496380 chr5:211416 CCDC127 -0.91 -10.24 -0.49 1.56e-21 Breast cancer; CRC cis rs853679 0.569 rs9348798 chr6:28143011 G/A cg18032046 chr6:28092343 ZSCAN16 -0.52 -5.93 -0.31 7.58e-9 Depression; CRC cis rs7044106 0.708 rs10984992 chr9:123473416 G/A cg09419670 chr9:123605666 PSMD5;LOC253039 0.73 11.81 0.55 4.61e-27 Hip circumference adjusted for BMI; CRC cis rs7177699 0.557 rs9920968 chr15:79118747 G/A cg15571903 chr15:79123663 NA 0.31 6.14 0.32 2.42e-9 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; CRC cis rs7917772 0.503 rs746552 chr10:104342501 A/G cg04362960 chr10:104952993 NT5C2 -0.42 -5.92 -0.31 8.03e-9 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC cis rs7618915 0.501 rs11130308 chr3:52639257 G/C cg05573699 chr3:52720067 GNL3;PBRM1 -0.48 -6.97 -0.36 1.75e-11 Bipolar disorder; CRC cis rs832540 0.629 rs10461616 chr5:56080347 T/C cg24531977 chr5:56204891 C5orf35 -0.51 -7.55 -0.38 4.33e-13 Coronary artery disease; CRC trans rs264943 0.783 rs7583069 chr2:104231852 C/T cg19630665 chr10:5523276 NA 0.36 6.14 0.32 2.42e-9 HIV-1 viral setpoint; CRC cis rs7727544 1.000 rs10076701 chr5:131596419 A/G cg18758796 chr5:131593413 PDLIM4 0.36 6.92 0.36 2.42e-11 Blood metabolite levels; CRC trans rs561341 0.825 rs2008368 chr17:30347397 T/C cg27661571 chr11:113659931 NA -0.93 -10.77 -0.51 2.28e-23 Hip circumference adjusted for BMI; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg25312966 chr22:24408316 CABIN1 0.44 6.21 0.32 1.57e-9 Response to antipsychotic treatment; CRC cis rs3809566 1.000 rs4774471 chr15:63332645 A/T cg05507819 chr15:63340323 TPM1 -0.45 -6.94 -0.36 2.16e-11 Platelet count; CRC cis rs10791097 0.694 rs4457753 chr11:130755575 A/G cg12179176 chr11:130786555 SNX19 0.75 12.56 0.57 8.09e-30 Autism spectrum disorder or schizophrenia;Schizophrenia; CRC cis rs2692947 0.832 rs2438978 chr2:96679740 G/C cg23100626 chr2:96804247 ASTL 0.27 7.02 0.36 1.29e-11 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; CRC cis rs11931598 0.513 rs3857170 chr4:7003366 A/T cg26116260 chr4:7069785 GRPEL1 0.45 6.9 0.36 2.67e-11 Sum basophil neutrophil counts;Sum neutrophil eosinophil counts;Granulocyte count;Neutrophil count;Myeloid white cell count; CRC cis rs875971 0.767 rs61348003 chr7:66005934 C/T cg18252515 chr7:66147081 NA -0.43 -6.23 -0.32 1.43e-9 Aortic root size; CRC trans rs4675374 0.505 rs61118437 chr2:204795383 C/T cg03032253 chr19:4652450 TNFAIP8L1 0.52 6.01 0.31 4.84e-9 Celiac disease; CRC cis rs4722166 0.630 rs12700390 chr7:22777129 G/T cg26061582 chr7:22766209 IL6 0.55 8.35 0.42 1.92e-15 Lung cancer; CRC cis rs6088580 0.634 rs7271970 chr20:32987666 A/G cg08999081 chr20:33150536 PIGU -0.62 -11.54 -0.54 4.29e-26 Glomerular filtration rate (creatinine); CRC cis rs1552244 0.810 rs4019706 chr3:10112862 G/A cg08888203 chr3:10149979 C3orf24 0.7 9.84 0.48 3.31e-20 Alzheimer's disease; CRC cis rs11971779 0.590 rs6467839 chr7:139062790 T/C cg23387468 chr7:139079360 LUC7L2 0.4 6.93 0.36 2.23e-11 Diisocyanate-induced asthma; CRC cis rs1223397 0.651 rs202018 chr6:13301502 G/A cg20827128 chr6:13274284 PHACTR1 0.37 5.69 0.3 2.8e-8 Blood pressure; CRC cis rs1865760 0.566 rs9348706 chr6:26065481 G/C cg16482183 chr6:26056742 HIST1H1C 0.52 7.63 0.39 2.51e-13 Height; CRC cis rs4664293 0.867 rs4665110 chr2:160587525 C/T cg08347373 chr2:160653686 CD302 -0.47 -7.43 -0.38 9.32e-13 Monocyte percentage of white cells; CRC cis rs9322193 0.923 rs62439842 chr6:149996983 G/A cg13206674 chr6:150067644 NUP43 0.63 9.32 0.46 1.7e-18 Lung cancer; CRC cis rs600806 0.888 rs3853500 chr1:109864269 T/C cg23032129 chr1:109941072 SORT1 -0.28 -6.04 -0.32 4.16e-9 Intelligence (multi-trait analysis); CRC cis rs12893668 0.703 rs35498576 chr14:104025893 T/C cg01849466 chr14:104193079 ZFYVE21 -0.38 -5.87 -0.31 1.08e-8 Reticulocyte count; CRC trans rs2727020 0.590 rs7949936 chr11:49378902 G/A cg11707556 chr5:10655725 ANKRD33B -0.44 -6.66 -0.34 1.12e-10 Coronary artery disease; CRC cis rs3857067 0.806 rs7669168 chr4:95104881 G/T cg11021082 chr4:95130006 SMARCAD1 -0.49 -7.62 -0.39 2.68e-13 QT interval; CRC cis rs6952808 0.582 rs10479762 chr7:2045351 T/C cg00106254 chr7:1943704 MAD1L1 0.43 6.62 0.34 1.48e-10 Bipolar disorder and schizophrenia; CRC trans rs7618501 1.000 rs57648519 chr3:49813169 C/A cg21665057 chr3:196295764 WDR53;FBXO45 0.86 16.08 0.66 2.35e-43 Intelligence (multi-trait analysis); CRC cis rs7647973 0.769 rs6446204 chr3:49034879 T/C cg07636037 chr3:49044803 WDR6 0.86 10.33 0.49 7.36e-22 Menarche (age at onset); CRC cis rs11112613 0.775 rs61200462 chr12:105969271 G/A cg03607813 chr12:105948248 NA 0.77 9.89 0.48 2.23e-20 Corrected insulin response;Corrected insulin response adjusted for insulin sensitivity index; CRC cis rs1348850 0.914 rs3813259 chr2:178257214 G/A cg22681709 chr2:178499509 PDE11A -0.37 -6.86 -0.35 3.52e-11 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs2019137 0.936 rs12620738 chr2:113963739 C/T cg21482265 chr2:113992762 PAX8;LOC440839;LOC654433 -0.48 -6.78 -0.35 5.48e-11 Lymphocyte counts; CRC trans rs7178691 0.705 rs1906445 chr15:53891205 T/C cg05337636 chr17:78720537 RPTOR -0.47 -6.34 -0.33 7.45e-10 Fear of severe pain; CRC cis rs12497850 0.931 rs13064911 chr3:48952385 A/G cg20833759 chr3:49053208 WDR6;DALRD3 0.53 9.14 0.45 6.63e-18 Parkinson's disease; CRC cis rs7737355 0.812 rs251012 chr5:131030295 A/G cg25547332 chr5:131281432 NA -0.37 -6.05 -0.32 3.96e-9 Life satisfaction; CRC cis rs6952808 0.964 rs6945719 chr7:1932688 G/A cg02951883 chr7:2050386 MAD1L1 -0.72 -11.52 -0.54 4.96e-26 Bipolar disorder and schizophrenia; CRC cis rs12477438 0.798 rs12477754 chr2:99628073 G/A cg26064155 chr2:99771622 LIPT1;TSGA10 -0.79 -11.23 -0.53 5.3e-25 Chronic sinus infection; CRC cis rs4819052 0.788 rs9978857 chr21:46705155 T/G cg02159808 chr21:46707872 POFUT2;LOC642852 0.55 7.4 0.38 1.12e-12 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs758324 0.947 rs615305 chr5:131291856 A/G cg06307176 chr5:131281290 NA -0.39 -5.65 -0.3 3.39e-8 Alzheimer's disease in APOE e4- carriers; CRC cis rs600806 0.821 rs4970840 chr1:109873367 A/G cg23032129 chr1:109941072 SORT1 -0.27 -5.8 -0.3 1.59e-8 Intelligence (multi-trait analysis); CRC cis rs354225 0.565 rs2971880 chr2:54885640 A/T cg26097391 chr2:54893211 SPTBN1 0.53 9.57 0.47 2.58e-19 Schizophrenia; CRC cis rs13272623 0.502 rs268627 chr8:71561041 C/T cg23757474 chr8:71581111 LACTB2;XKR9 -0.47 -6.77 -0.35 5.98e-11 IgG glycosylation; CRC trans rs2012709 0.870 rs4867114 chr5:32550128 C/T cg03755955 chr8:6424269 MCPH1 -0.43 -6.47 -0.34 3.49e-10 Breast cancer; CRC cis rs2439831 0.850 rs68079546 chr15:44136957 G/T cg02155558 chr15:43621948 ADAL;LCMT2 0.65 7.16 0.37 5.44e-12 Lung cancer in ever smokers; CRC cis rs1862618 0.853 rs252916 chr5:56121788 G/C cg12311346 chr5:56204834 C5orf35 -0.75 -10.15 -0.49 3.15e-21 Initial pursuit acceleration; CRC cis rs7613875 0.600 rs1061474 chr3:50144951 T/C cg24308560 chr3:49941425 MST1R 0.4 6.01 0.31 5.01e-9 Body mass index; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg13885325 chr10:89623122 PTEN;KILLIN 0.45 6.21 0.32 1.58e-9 Anxiety disorder; CRC cis rs17152411 1.000 rs11245432 chr10:126616861 G/A cg07906193 chr10:126599966 NA 0.58 5.68 0.3 2.98e-8 Height; CRC cis rs873946 0.586 rs3793685 chr10:134569316 G/A cg18305652 chr10:134549665 INPP5A 0.49 6.26 0.33 1.23e-9 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CRC cis rs7249142 0.597 rs7250650 chr19:19285989 A/T cg08207377 chr19:19281140 LOC729991-MEF2B;MEF2B -0.38 -6.18 -0.32 1.91e-9 IgG glycosylation; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg20624980 chr19:50432627 NUP62;ATF5;IL4I1 0.44 7.25 0.37 2.91e-12 Liver disease severity in Alagille syndrome; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg13338022 chr15:43029438 CDAN1 0.42 6.15 0.32 2.29e-9 Intelligence (multi-trait analysis); CRC cis rs8180040 0.966 rs2291298 chr3:47555142 C/A cg27129171 chr3:47204927 SETD2 0.53 8.16 0.41 7.24e-15 Colorectal cancer; CRC cis rs2257205 0.667 rs7209498 chr17:56680642 G/A cg25885038 chr17:56607967 SEPT4 -0.55 -5.99 -0.31 5.54e-9 Pancreatic cancer; CRC cis rs9467711 0.606 rs28360517 chr6:26602453 A/G cg12315302 chr6:26189340 HIST1H4D 0.76 6.0 0.31 5.23e-9 Autism spectrum disorder or schizophrenia; CRC cis rs875971 0.545 rs75577046 chr7:65958716 A/G cg18876405 chr7:65276391 NA 0.46 6.37 0.33 6.52e-10 Aortic root size; CRC cis rs3790844 0.876 rs3790847 chr1:200006217 G/T cg07208853 chr1:200005219 NR5A2 0.36 8.98 0.44 2.09e-17 Pancreatic cancer; CRC cis rs1552244 0.572 rs3894322 chr3:10168965 G/A cg00166722 chr3:10149974 C3orf24 0.66 7.71 0.39 1.49e-13 Alzheimer's disease; CRC cis rs4862750 0.872 rs6836781 chr4:187899701 G/A cg27532560 chr4:187881888 NA -0.57 -10.58 -0.5 1.04e-22 Lobe attachment (rater-scored or self-reported); CRC cis rs853679 0.517 rs3734573 chr6:28059437 T/C cg12273811 chr6:28175739 NA 0.74 9.41 0.46 8.58e-19 Depression; CRC cis rs13323323 0.691 rs9814256 chr3:44668037 A/T cg11003573 chr3:44754125 ZNF502 -0.41 -5.81 -0.3 1.51e-8 IgG glycosylation; CRC cis rs1552244 0.572 rs66514627 chr3:10166632 A/C cg18598329 chr3:10140678 FANCD2;C3orf24 -0.91 -10.81 -0.51 1.62e-23 Alzheimer's disease; CRC cis rs7107770 0.583 rs1808861 chr11:125073943 G/C cg27629782 chr11:125073726 PKNOX2 0.51 7.26 0.37 2.84e-12 Photic sneeze reflex; CRC cis rs6963495 0.818 rs6961863 chr7:105180953 C/T cg02135003 chr7:105160482 PUS7 -0.73 -10.52 -0.5 1.68e-22 Bipolar disorder (body mass index interaction); CRC cis rs1572438 0.862 rs4959468 chr6:858056 C/A cg13447295 chr6:887704 NA -0.42 -6.13 -0.32 2.58e-9 Aging; CRC cis rs4604732 0.631 rs7546720 chr1:247627229 G/A cg12758973 chr1:247694275 LOC148824;OR2C3 0.42 6.14 0.32 2.32e-9 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CRC cis rs7512552 0.839 rs834232 chr1:150354682 T/C cg15654264 chr1:150340011 RPRD2 0.58 8.56 0.43 4.48e-16 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); CRC cis rs17767392 1.000 rs35854505 chr14:71841477 C/T cg13720639 chr14:72061746 SIPA1L1 -0.54 -6.77 -0.35 5.81e-11 Mitral valve prolapse; CRC cis rs9381040 0.537 rs9462669 chr6:41013659 C/A cg04346459 chr6:41068666 NFYA;LOC221442 -0.42 -6.16 -0.32 2.18e-9 Alzheimer's disease (late onset); CRC cis rs2066819 1.000 rs118130855 chr12:56677979 T/A cg26714650 chr12:56694279 CS -1.41 -11.64 -0.54 1.88e-26 Psoriasis vulgaris; CRC cis rs782590 0.738 rs4312532 chr2:55812061 A/G cg18811423 chr2:55921094 PNPT1 -0.73 -12.24 -0.56 1.25e-28 Metabolic syndrome; CRC cis rs9910055 0.762 rs2240226 chr17:42266218 C/T cg13607699 chr17:42295918 UBTF 0.5 6.7 0.35 9e-11 Total body bone mineral density; CRC cis rs10971721 0.822 rs11848 chr9:33921919 T/C cg13495928 chr9:33750294 PRSS3 0.56 5.97 0.31 6.15e-9 Body mass index; CRC trans rs2797160 0.651 rs1268092 chr6:126029043 A/G cg05039488 chr6:79577232 IRAK1BP1 -0.53 -8.11 -0.41 1.03e-14 Endometrial cancer; CRC cis rs796364 0.950 rs56155997 chr2:200768491 C/T cg25936922 chr2:200820526 C2orf60;C2orf47 -0.77 -7.41 -0.38 1.04e-12 Schizophrenia; CRC cis rs7666738 0.830 rs2865951 chr4:99040191 C/T cg05340658 chr4:99064831 C4orf37 0.59 9.1 0.45 8.57e-18 Colonoscopy-negative controls vs population controls; CRC cis rs11098499 0.909 rs28714195 chr4:120316950 A/T cg09307838 chr4:120376055 NA 0.71 10.84 0.51 1.34e-23 Corneal astigmatism; CRC cis rs1707322 1.000 rs11211204 chr1:46317864 A/G cg03146154 chr1:46216737 IPP 0.5 7.0 0.36 1.43e-11 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs6952808 0.689 rs12670737 chr7:2046830 C/T cg22963979 chr7:1858916 MAD1L1 -0.49 -7.23 -0.37 3.31e-12 Bipolar disorder and schizophrenia; CRC cis rs6728642 0.519 rs7589232 chr2:97566148 C/T cg26665480 chr2:98280029 ACTR1B -0.55 -6.13 -0.32 2.54e-9 Bipolar disorder lithium response (continuous) or schizophrenia; CRC trans rs7267979 0.844 rs4423675 chr20:25402778 A/G cg17903999 chr18:56338584 MALT1 0.41 6.64 0.34 1.26e-10 Liver enzyme levels (alkaline phosphatase); CRC cis rs4722166 0.630 rs10950916 chr7:22799667 C/T cg26061582 chr7:22766209 IL6 0.52 7.88 0.4 4.75e-14 Lung cancer; CRC cis rs11212617 0.967 rs228608 chr11:108088900 C/T cg14761454 chr11:108092087 ATM;NPAT 0.42 6.36 0.33 6.7e-10 Response to metformin in type 2 diabetes (glycemic); CRC cis rs66573146 1.000 rs55688389 chr4:7030689 C/G cg15105060 chr4:7024189 TBC1D14 -0.69 -5.86 -0.31 1.14e-8 Granulocyte percentage of myeloid white cells; CRC cis rs7727544 0.684 rs274561 chr5:131719228 A/C cg07395648 chr5:131743802 NA -0.41 -6.49 -0.34 3.08e-10 Blood metabolite levels; CRC cis rs9303280 0.806 rs10852936 chr17:38031714 C/T cg11212589 chr17:38028394 ZPBP2 0.44 8.0 0.4 2.18e-14 Self-reported allergy; CRC cis rs10883723 0.810 rs2296581 chr10:104242886 G/A cg11453585 chr10:104263688 ACTR1A;SUFU 0.9 15.71 0.65 7.04e-42 Allergic disease (asthma, hay fever or eczema); CRC cis rs1577917 0.958 rs6454487 chr6:86446868 A/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A 0.56 7.67 0.39 2e-13 Response to antipsychotic treatment; CRC cis rs12530845 0.623 rs77454235 chr7:135341862 T/C cg23117316 chr7:135346802 PL-5283 -0.45 -5.81 -0.3 1.48e-8 Red blood cell traits; CRC cis rs6866344 0.697 rs17184344 chr5:178129281 A/G cg03877680 chr5:178157825 ZNF354A 0.79 11.28 0.53 3.52e-25 Neutrophil percentage of white cells; CRC cis rs13118159 0.527 rs1250119 chr4:1261336 G/A cg16405210 chr4:1374714 KIAA1530 0.9 13.48 0.6 2.92e-33 Longevity; CRC cis rs12893668 0.703 rs34896432 chr14:104027995 C/T cg08213375 chr14:104286397 PPP1R13B 0.4 6.24 0.33 1.31e-9 Reticulocyte count; CRC trans rs7615952 0.599 rs2270986 chr3:125701099 T/C cg07211511 chr3:129823064 LOC729375 -0.79 -10.9 -0.52 7.88e-24 Blood pressure (smoking interaction); CRC cis rs10911363 0.592 rs2702177 chr1:183450622 G/C cg09173681 chr1:183549694 NCF2 0.73 10.13 0.49 3.49e-21 Systemic lupus erythematosus; CRC cis rs2742417 0.904 rs2373047 chr3:45747497 C/A cg04837898 chr3:45731254 SACM1L -0.36 -5.92 -0.31 7.98e-9 Response to anti-depressant treatment in major depressive disorder; CRC cis rs35306767 0.903 rs12250936 chr10:870109 C/T cg26597838 chr10:835615 NA 0.93 11.28 0.53 3.54e-25 Eosinophil percentage of granulocytes; CRC trans rs9858542 0.953 rs9858280 chr3:49597737 T/C cg21665057 chr3:196295764 WDR53;FBXO45 -0.67 -9.18 -0.45 4.77e-18 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs11650494 0.710 rs11654557 chr17:47390136 A/G cg08112188 chr17:47440006 ZNF652 1.26 11.54 0.54 4.31e-26 Prostate cancer; CRC cis rs6933660 0.745 rs3778608 chr6:151738131 A/G cg14262678 chr6:151773367 RMND1;C6orf211 0.5 8.15 0.41 7.77e-15 Menarche (age at onset); CRC cis rs10924970 0.934 rs6666023 chr1:235480068 G/A cg26050004 chr1:235667680 B3GALNT2 0.41 6.08 0.32 3.36e-9 Asthma; CRC cis rs2692947 0.644 rs772175 chr2:96944553 G/A cg23100626 chr2:96804247 ASTL 0.28 7.18 0.37 4.71e-12 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; CRC trans rs208520 1.000 rs12193077 chr6:66989548 C/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.89 10.88 0.51 9.5e-24 Exhaled nitric oxide output; CRC cis rs1080500 1.000 rs1080500 chr3:53175017 C/T cg18099408 chr3:52552593 STAB1 -0.38 -5.8 -0.3 1.6e-8 Autism spectrum disorder or schizophrenia; CRC cis rs9325144 0.600 rs2171405 chr12:38741030 G/T cg13010199 chr12:38710504 ALG10B -0.41 -5.96 -0.31 6.61e-9 Morning vs. evening chronotype; CRC trans rs1005277 0.557 rs176887 chr10:38406094 T/C cg27523141 chr10:43048294 ZNF37B 0.5 7.25 0.37 3.04e-12 Extrinsic epigenetic age acceleration; CRC cis rs12908161 1.000 rs35726233 chr15:85337800 C/T cg17507749 chr15:85114479 UBE2QP1 0.62 8.75 0.43 1.15e-16 Schizophrenia; CRC cis rs12024301 0.557 rs12031263 chr1:183591586 T/G cg11505048 chr1:183622726 RGL1;APOBEC4 0.76 6.93 0.36 2.16e-11 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs12580194 0.593 rs7976828 chr12:55726450 A/T cg19537932 chr12:55886519 OR6C68 -0.69 -8.71 -0.43 1.49e-16 Cancer; CRC cis rs9325144 0.600 rs34138871 chr12:38735261 A/G cg26384229 chr12:38710491 ALG10B 0.53 8.04 0.41 1.66e-14 Morning vs. evening chronotype; CRC cis rs769267 0.631 rs7252981 chr19:19692579 T/C cg03709012 chr19:19516395 GATAD2A -0.55 -7.29 -0.37 2.38e-12 Tonsillectomy; CRC trans rs3780486 0.846 rs7850878 chr9:33126570 A/G cg20290983 chr6:43655470 MRPS18A 1.16 27.05 0.83 1.25e-85 IgG glycosylation; CRC cis rs1448094 0.845 rs7966131 chr12:86350633 T/G cg00310523 chr12:86230176 RASSF9 0.45 7.56 0.38 3.97e-13 Major depressive disorder; CRC cis rs9837602 0.529 rs793494 chr3:99508768 T/C cg07805332 chr3:99536008 MIR548G;C3orf26 0.49 7.29 0.37 2.28e-12 Breast cancer; CRC trans rs11148252 0.904 rs9536079 chr13:53030565 G/A cg18335740 chr13:41363409 SLC25A15 0.61 9.69 0.47 1.07e-19 Lewy body disease; CRC cis rs12762955 0.529 rs2387213 chr10:1051420 C/T cg26597838 chr10:835615 NA 0.46 6.1 0.32 3.05e-9 Response to angiotensin II receptor blocker therapy; CRC cis rs10504229 0.683 rs1495865 chr8:58141160 T/G cg22535103 chr8:58192502 C8orf71 -0.7 -9.34 -0.46 1.47e-18 Developmental language disorder (linguistic errors); CRC cis rs3096299 0.967 rs2965935 chr16:89481274 C/T cg01788221 chr16:89496183 ANKRD11 0.44 6.78 0.35 5.54e-11 Multiple myeloma (IgH translocation); CRC cis rs875971 0.964 rs160635 chr7:65528918 T/C cg18876405 chr7:65276391 NA 0.52 8.97 0.44 2.22e-17 Aortic root size; CRC cis rs1348850 0.561 rs4893956 chr2:178373452 C/T cg27490568 chr2:178487706 NA 0.58 7.08 0.36 8.66e-12 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs13315871 0.790 rs13071148 chr3:58310838 A/C cg20936604 chr3:58311152 NA -0.76 -7.13 -0.37 6.48e-12 Cholesterol, total; CRC cis rs9486715 0.838 rs7770889 chr6:96858453 C/T cg06623918 chr6:96969491 KIAA0776 -0.95 -17.36 -0.69 2.28e-48 Headache; CRC cis rs2880765 0.743 rs6497194 chr15:86014116 C/T cg17133734 chr15:86042851 AKAP13 0.39 6.19 0.32 1.82e-9 Coronary artery disease; CRC cis rs4132509 0.947 rs10927039 chr1:243721726 C/T cg21452805 chr1:244014465 NA -0.42 -5.97 -0.31 6.11e-9 RR interval (heart rate); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg23805785 chr1:32671112 IQCC 0.37 6.11 0.32 2.76e-9 Liver disease severity in Alagille syndrome; CRC cis rs7927997 0.757 rs2212434 chr11:76281593 C/T cg10400081 chr11:76299682 NA -0.4 -7.29 -0.37 2.27e-12 Gut microbiota (functional units);Crohn's disease; CRC cis rs6570726 0.791 rs6902410 chr6:145905261 G/A cg13319975 chr6:146136371 FBXO30 -0.42 -6.28 -0.33 1.04e-9 Lobe attachment (rater-scored or self-reported); CRC trans rs2727020 0.595 rs11040416 chr11:49566429 C/T cg03929089 chr4:120376271 NA -0.92 -17.07 -0.69 3.23e-47 Coronary artery disease; CRC cis rs12188164 0.930 rs72717440 chr5:449701 A/T cg21972741 chr5:435613 AHRR 0.55 7.56 0.38 4.15e-13 Cystic fibrosis severity; CRC cis rs7072216 0.922 rs942813 chr10:100153608 A/C cg26618903 chr10:100175079 PYROXD2 -0.37 -6.13 -0.32 2.58e-9 Metabolite levels; CRC cis rs2692947 0.832 rs4907212 chr2:96410048 T/A cg23100626 chr2:96804247 ASTL 0.26 6.72 0.35 7.95e-11 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; CRC cis rs881375 0.967 rs2416806 chr9:123690292 G/C cg09586646 chr9:123605570 PSMD5;LOC253039 0.47 6.46 0.34 3.69e-10 Rheumatoid arthritis; CRC cis rs832540 0.629 rs10940512 chr5:56082094 G/C cg18230493 chr5:56204884 C5orf35 -0.42 -5.99 -0.31 5.39e-9 Coronary artery disease; CRC cis rs282587 0.597 rs450351 chr13:113394987 C/T cg04656015 chr13:113407548 ATP11A 0.61 7.47 0.38 7.36e-13 Glycated hemoglobin levels; CRC cis rs6460942 0.643 rs7780093 chr7:12233661 C/G cg06484146 chr7:12443880 VWDE -0.58 -6.08 -0.32 3.36e-9 Coronary artery disease; CRC trans rs1814175 0.817 rs1818890 chr11:49856882 T/C cg11707556 chr5:10655725 ANKRD33B -0.42 -7.87 -0.4 5.18e-14 Height; CRC cis rs4594175 0.926 rs12323654 chr14:51630894 G/T cg23942311 chr14:51606299 NA 0.61 9.72 0.47 8.46e-20 Cancer; CRC cis rs9287719 0.934 rs4371336 chr2:10755723 C/A cg00105475 chr2:10696890 NA 0.45 7.17 0.37 4.85e-12 Prostate cancer; CRC cis rs4664293 0.647 rs10198053 chr2:160461680 G/A cg08347373 chr2:160653686 CD302 -0.39 -6.49 -0.34 3.11e-10 Monocyte percentage of white cells; CRC cis rs1448094 0.817 rs10779220 chr12:86323543 T/A cg02569458 chr12:86230093 RASSF9 0.46 7.68 0.39 1.89e-13 Major depressive disorder; CRC cis rs11148252 0.595 rs9526968 chr13:53240183 T/C cg00495681 chr13:53174319 NA 0.84 15.41 0.65 1.01e-40 Lewy body disease; CRC cis rs6502050 0.835 rs11077971 chr17:80090629 A/G cg22110888 chr17:80059540 CCDC57 0.41 6.42 0.33 4.87e-10 Life satisfaction; CRC cis rs10986311 0.775 rs7872979 chr9:127104412 G/A cg14243010 chr9:127117328 LOC100129034;PSMB7 0.4 6.1 0.32 2.94e-9 Vitiligo; CRC trans rs2727020 0.514 rs4980444 chr11:49550764 T/A cg11707556 chr5:10655725 ANKRD33B -0.4 -7.5 -0.38 6.16e-13 Coronary artery disease; CRC cis rs9322193 0.923 rs35961297 chr6:149989065 T/C cg00933542 chr6:150070202 PCMT1 0.28 5.77 0.3 1.85e-8 Lung cancer; CRC cis rs35306767 0.903 rs765867 chr10:869901 G/T cg20503657 chr10:835505 NA 0.91 11.34 0.53 2.16e-25 Eosinophil percentage of granulocytes; CRC trans rs1602565 1.000 rs1907605 chr11:29158507 A/G cg20483690 chr1:225616668 LBR -0.64 -6.7 -0.35 8.85e-11 Schizophrenia; CRC trans rs7580658 0.614 rs7585198 chr2:127962635 C/T cg26797661 chr1:151138516 LYSMD1;SCNM1 -0.42 -6.01 -0.31 4.88e-9 Protein C levels; CRC cis rs7772486 0.743 rs9403742 chr6:146060193 A/C cg13319975 chr6:146136371 FBXO30 -0.41 -6.2 -0.32 1.69e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs6963495 0.818 rs73192120 chr7:105171156 C/T cg02135003 chr7:105160482 PUS7 -0.92 -12.46 -0.57 1.94e-29 Bipolar disorder (body mass index interaction); CRC cis rs2969070 0.763 rs4721714 chr7:2498467 G/A cg03277898 chr7:2518824 NA -0.43 -6.2 -0.32 1.65e-9 Diastolic blood pressure; CRC cis rs2295359 0.892 rs56920441 chr1:67652012 A/G cg17031739 chr1:67600172 NA 0.37 5.87 0.31 1.07e-8 Psoriasis; CRC cis rs1949733 0.585 rs2631768 chr4:8473050 A/G cg11789530 chr4:8429930 ACOX3 -0.66 -9.52 -0.46 4.02e-19 Response to antineoplastic agents; CRC cis rs4900538 0.855 rs60215817 chr14:102873886 A/G cg18135206 chr14:102964638 TECPR2 -0.97 -17.52 -0.69 5.33e-49 Mean corpuscular volume;Mean corpuscular hemoglobin; CRC cis rs7618915 0.501 rs2336146 chr3:52626646 A/G cg05573699 chr3:52720067 GNL3;PBRM1 -0.47 -6.96 -0.36 1.87e-11 Bipolar disorder; CRC cis rs1153858 1.000 rs8032904 chr15:45651309 C/T cg21132104 chr15:45694354 SPATA5L1 0.6 8.87 0.44 4.85e-17 Homoarginine levels; CRC cis rs3749237 0.595 rs4855861 chr3:49525962 G/T cg03060546 chr3:49711283 APEH 0.69 11.93 0.55 1.62e-27 Resting heart rate; CRC cis rs473651 0.716 rs548179 chr2:239320505 G/A cg21699342 chr2:239360505 ASB1 0.53 9.39 0.46 1.07e-18 Multiple system atrophy; CRC cis rs6951245 1.000 rs76388414 chr7:1100694 G/A cg04025307 chr7:1156635 C7orf50 0.64 6.81 0.35 4.53e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs9322193 0.887 rs9505824 chr6:149954799 A/G cg07701084 chr6:150067640 NUP43 0.55 8.04 0.41 1.58e-14 Lung cancer; CRC cis rs9488822 0.596 rs13192549 chr6:116338352 C/A cg05304507 chr6:116381966 FRK 0.29 7.4 0.38 1.16e-12 Cholesterol, total;LDL cholesterol; CRC cis rs7493 0.950 rs6961624 chr7:95037661 T/C cg07404485 chr7:94953653 PON1 -0.45 -6.04 -0.32 4.26e-9 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs7762018 0.607 rs77004024 chr6:170063437 G/A cg24289452 chr6:170231220 NA -0.81 -7.02 -0.36 1.31e-11 Thiazide-induced adverse metabolic effects in hypertensive patients; CRC cis rs2898681 0.567 rs77657787 chr4:53729981 G/A cg26260408 chr4:53727979 RASL11B 0.5 5.73 0.3 2.29e-8 Optic nerve measurement (cup area); CRC cis rs9992667 0.955 rs28664852 chr4:38646100 A/C cg19726192 chr4:38663646 FLJ13197 -0.66 -8.74 -0.43 1.23e-16 Eosinophil percentage of granulocytes; CRC cis rs10504229 0.554 rs17802082 chr8:58095867 C/T cg02725872 chr8:58115012 NA -0.45 -6.82 -0.35 4.42e-11 Developmental language disorder (linguistic errors); CRC cis rs12995491 0.698 rs34352413 chr2:88498754 T/G cg07952391 chr2:88470173 THNSL2 -0.45 -6.59 -0.34 1.78e-10 Response to metformin (IC50); CRC cis rs950169 1.000 rs34751999 chr15:84758419 T/C cg03959625 chr15:84868606 LOC388152 0.41 6.07 0.32 3.55e-9 Schizophrenia; CRC cis rs11214589 0.875 rs10891540 chr11:113239082 A/G cg14159747 chr11:113255604 NA -0.5 -9.76 -0.47 6.4e-20 Neuroticism; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg03041860 chr2:208489911 FAM119A 0.47 6.53 0.34 2.45e-10 Response to antipsychotic treatment; CRC cis rs10504229 0.683 rs55637580 chr8:58135419 C/T cg05313129 chr8:58192883 C8orf71 -0.43 -6.11 -0.32 2.74e-9 Developmental language disorder (linguistic errors); CRC cis rs4713118 0.614 rs9468209 chr6:27694421 C/T cg15786705 chr6:28176104 NA 0.46 6.71 0.35 8.45e-11 Parkinson's disease; CRC cis rs1843834 0.574 rs6436499 chr2:225456551 A/T cg22509189 chr2:225307070 NA -0.39 -5.8 -0.3 1.57e-8 IgE levels in asthmatics (D.p. specific); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg05314271 chr8:28747585 INTS9;HMBOX1 0.46 6.68 0.35 1.04e-10 Intelligence (multi-trait analysis); CRC cis rs4474465 0.833 rs10793320 chr11:78217460 G/A cg27205649 chr11:78285834 NARS2 0.47 5.81 0.3 1.5e-8 Alzheimer's disease (survival time); CRC cis rs754466 0.606 rs11002309 chr10:79594931 C/T cg17075019 chr10:79541650 NA -0.98 -18.04 -0.71 4.72e-51 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs3617 0.559 rs11915546 chr3:52866845 A/C cg07507251 chr3:52567010 NT5DC2 -0.4 -6.2 -0.32 1.66e-9 Red blood cell count;Autism spectrum disorder or schizophrenia; CRC cis rs1218582 0.772 rs12069356 chr1:154849771 C/T cg03351412 chr1:154909251 PMVK 0.52 8.36 0.42 1.85e-15 Prostate cancer; CRC cis rs1799949 1.000 rs11657835 chr17:41291953 C/G cg23758822 chr17:41437982 NA 0.8 13.44 0.6 3.93e-33 Menopause (age at onset); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg26794364 chr3:9691143 MTMR14 0.36 6.56 0.34 2.11e-10 Liver disease severity in Alagille syndrome; CRC cis rs2952156 0.959 rs2934952 chr17:37832366 G/A cg00129232 chr17:37814104 STARD3 -0.69 -11.58 -0.54 3.03e-26 Asthma; CRC cis rs1862618 0.853 rs10051747 chr5:56083289 C/A cg18230493 chr5:56204884 C5orf35 -0.76 -9.69 -0.47 1.07e-19 Initial pursuit acceleration; CRC trans rs2228479 0.850 rs11649162 chr16:89807131 C/A cg24644049 chr4:85504048 CDS1 0.9 7.41 0.38 1.05e-12 Skin colour saturation; CRC cis rs2075371 0.764 rs1643034 chr7:134006176 A/G cg02659138 chr7:134003124 SLC35B4 0.45 7.94 0.4 3.16e-14 Mean platelet volume; CRC cis rs9291683 0.588 rs17247314 chr4:10004743 C/G cg11266682 chr4:10021025 SLC2A9 0.53 10.73 0.51 3.07e-23 Bone mineral density; CRC cis rs6460942 0.591 rs6942432 chr7:12338393 A/G cg20607287 chr7:12443886 VWDE -0.55 -6.23 -0.32 1.41e-9 Coronary artery disease; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg18881247 chr2:157189314 NR4A2 -0.42 -6.65 -0.34 1.26e-10 Myopia (pathological); CRC cis rs4843747 0.619 rs66508972 chr16:88086385 C/G cg03395651 chr16:88107091 BANP 0.56 7.19 0.37 4.43e-12 Menopause (age at onset); CRC cis rs6502050 0.769 rs8079122 chr17:80120427 G/T cg25804541 chr17:80189381 SLC16A3 -0.3 -5.83 -0.31 1.3e-8 Life satisfaction; CRC trans rs79976124 0.797 rs74995761 chr6:66640216 G/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.77 9.59 0.47 2.32e-19 Type 2 diabetes; CRC cis rs11628318 0.803 rs2277468 chr14:103024080 A/G cg02094049 chr14:103021097 NA -0.48 -6.07 -0.32 3.48e-9 Platelet count; CRC cis rs6502050 0.604 rs9897355 chr17:80078095 G/A cg02741985 chr17:80059408 CCDC57 -0.44 -7.2 -0.37 4.13e-12 Life satisfaction; CRC cis rs9467773 0.620 rs2494694 chr6:26619328 A/T cg09904177 chr6:26538194 HMGN4 0.72 11.21 0.53 6.63e-25 Intelligence (multi-trait analysis); CRC cis rs7617773 0.780 rs13082859 chr3:48344675 C/T cg11946769 chr3:48343235 NME6 0.73 9.71 0.47 9.45e-20 Coronary artery disease; CRC cis rs4713118 0.868 rs760587 chr6:27740300 C/A cg15786705 chr6:28176104 NA 0.61 6.75 0.35 6.5e-11 Parkinson's disease; CRC cis rs453301 0.571 rs2929454 chr8:9083854 A/C cg08975724 chr8:8085496 FLJ10661 -0.4 -6.27 -0.33 1.12e-9 Joint mobility (Beighton score); CRC cis rs11577318 0.853 rs1071849 chr1:26646726 A/G cg00852783 chr1:26633632 UBXN11 0.48 6.77 0.35 5.83e-11 Granulocyte percentage of myeloid white cells; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg11718113 chr1:16011424 PLEKHM2 0.46 6.36 0.33 6.9e-10 Response to antipsychotic treatment; CRC cis rs1552244 0.572 rs3894323 chr3:10168967 G/A cg18598329 chr3:10140678 FANCD2;C3orf24 -0.9 -10.73 -0.51 3.19e-23 Alzheimer's disease; CRC cis rs10751667 0.666 rs4074234 chr11:977715 C/G cg06064525 chr11:970664 AP2A2 -0.3 -6.11 -0.32 2.78e-9 Alzheimer's disease (late onset); CRC cis rs10751667 0.621 rs10794348 chr11:939941 G/A cg01483505 chr11:975446 AP2A2 0.41 6.63 0.34 1.41e-10 Alzheimer's disease (late onset); CRC cis rs7727544 0.735 rs274559 chr5:131720070 A/G cg04518342 chr5:131593106 PDLIM4 -0.33 -5.85 -0.31 1.2e-8 Blood metabolite levels; CRC cis rs6748734 1.000 rs4675863 chr2:241830763 A/T cg07537917 chr2:241836409 C2orf54 -0.21 -6.03 -0.32 4.52e-9 Urinary metabolites; CRC cis rs17023223 0.537 rs12065809 chr1:119724535 A/T cg05756136 chr1:119680316 WARS2 -0.52 -7.14 -0.37 6e-12 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for BMI in active individuals; CRC cis rs9488822 0.676 rs12190737 chr6:116328128 C/A cg05304507 chr6:116381966 FRK 0.3 8.24 0.41 4.08e-15 Cholesterol, total;LDL cholesterol; CRC cis rs11155671 0.530 rs6933882 chr6:150210802 A/G cg13206674 chr6:150067644 NUP43 0.49 7.04 0.36 1.13e-11 Testicular germ cell tumor; CRC cis rs8103278 0.507 rs2041975 chr19:46238555 T/C cg20908204 chr19:46285434 DMPK 0.33 7.19 0.37 4.28e-12 Coronary artery disease; CRC cis rs597539 0.617 rs686348 chr11:68636996 A/G cg04772025 chr11:68637568 NA 0.51 8.11 0.41 1.04e-14 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs2836974 0.829 rs8128191 chr21:40527311 A/G cg11644478 chr21:40555479 PSMG1 0.82 13.39 0.59 6.26e-33 Cognitive function; CRC cis rs524023 0.957 rs561193 chr11:64353029 A/G cg06522879 chr11:64358276 SLC22A12 0.55 8.22 0.41 4.83e-15 Urate levels in obese individuals; CRC cis rs7647973 0.626 rs1996663 chr3:49878264 C/G cg13072238 chr3:49761600 GMPPB 0.51 6.05 0.32 3.95e-9 Menarche (age at onset); CRC cis rs995000 0.931 rs1168047 chr1:62983751 C/T cg19896129 chr1:63156450 NA -0.44 -6.91 -0.36 2.57e-11 Triglyceride levels; CRC cis rs6952808 0.893 rs35487994 chr7:1920171 G/A cg22963979 chr7:1858916 MAD1L1 -0.52 -7.79 -0.39 8.99e-14 Bipolar disorder and schizophrenia; CRC cis rs4662945 0.762 rs2406822 chr2:130218178 C/T cg05903289 chr2:130345205 NA -0.3 -5.76 -0.3 1.89e-8 Response to cytidine analogues (gemcitabine); CRC cis rs7618915 0.547 rs11130323 chr3:52770277 T/C cg18404041 chr3:52824283 ITIH1 -0.43 -8.78 -0.44 8.82e-17 Bipolar disorder; CRC cis rs1881797 1.000 rs67977965 chr1:247687835 G/A cg05639522 chr1:247681581 NA 0.46 6.95 0.36 1.91e-11 Acute lymphoblastic leukemia (childhood); CRC cis rs7811142 0.666 rs28401739 chr7:99905684 A/G cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.6 7.68 0.39 1.84e-13 Platelet count; CRC cis rs7924005 0.543 rs71479758 chr10:6177894 A/G cg17191567 chr10:6178319 NA -0.41 -5.95 -0.31 6.8e-9 Soluble interleukin-2 receptor subunit alpha; CRC cis rs938554 0.784 rs13131257 chr4:9981889 T/C cg00071950 chr4:10020882 SLC2A9 0.46 6.5 0.34 2.93e-10 Blood metabolite levels; CRC cis rs67311347 0.544 rs6762121 chr3:40355313 G/A cg09455208 chr3:40491958 NA 0.31 6.06 0.32 3.74e-9 Renal cell carcinoma; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg21249729 chr9:138392748 C9orf116;MRPS2 0.43 7.11 0.36 7.12e-12 Liver disease severity in Alagille syndrome; CRC cis rs1691799 0.899 rs1168305 chr12:66738714 A/G cg16791601 chr12:66731901 HELB -0.66 -10.92 -0.52 6.61e-24 White blood cell count (basophil); CRC cis rs870825 0.616 rs28459754 chr4:185636280 C/A cg04058563 chr4:185651563 MLF1IP 0.73 9.38 0.46 1.13e-18 Blood protein levels; CRC trans rs3749237 0.964 rs2234385 chr3:49846041 G/A cg21665057 chr3:196295764 WDR53;FBXO45 0.55 7.92 0.4 3.66e-14 Resting heart rate; CRC cis rs9463078 0.739 rs1293467 chr6:44769204 C/G cg25276700 chr6:44698697 NA 0.28 6.92 0.36 2.34e-11 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; CRC cis rs1355223 0.583 rs2941043 chr11:34870994 A/G cg24088639 chr11:34937564 PDHX;APIP 0.58 8.39 0.42 1.43e-15 Systemic lupus erythematosus and Systemic sclerosis; CRC cis rs394563 0.726 rs366905 chr6:149735097 T/A cg03678062 chr6:149772716 ZC3H12D -0.35 -6.38 -0.33 6.09e-10 Dupuytren's disease; CRC trans rs7618501 0.633 rs2353579 chr3:50027774 C/T cg21665057 chr3:196295764 WDR53;FBXO45 0.57 9.14 0.45 6.78e-18 Intelligence (multi-trait analysis); CRC cis rs17270561 0.609 rs9348694 chr6:25753640 C/T cg16482183 chr6:26056742 HIST1H1C 0.82 10.77 0.51 2.33e-23 Iron status biomarkers; CRC cis rs12541635 1.000 rs1366969 chr8:107092851 A/T cg10147462 chr8:107024639 NA -0.38 -6.39 -0.33 5.73e-10 Age of smoking initiation; CRC cis rs12701220 0.655 rs9638973 chr7:1133678 A/G cg00990874 chr7:1149470 C7orf50 -0.67 -8.79 -0.44 8.67e-17 Bronchopulmonary dysplasia; CRC cis rs2380220 0.808 rs2716072 chr6:95909773 A/G cg04719120 chr6:96025338 MANEA -0.53 -5.88 -0.31 9.93e-9 Behavioural disinhibition (generation interaction); CRC cis rs2072510 0.966 rs2660896 chr12:96423782 A/G cg22491680 chr12:96389547 HAL -0.39 -6.16 -0.32 2.08e-9 Metabolite levels (small molecules and protein measures); CRC cis rs9910055 0.639 rs7217858 chr17:42254527 T/G cg10896456 chr17:42255109 ASB16;C17orf65 0.45 7.71 0.39 1.47e-13 Total body bone mineral density; CRC cis rs7538876 0.935 rs11577822 chr1:17754608 T/G cg01904812 chr1:17746340 RCC2 0.37 5.94 0.31 7.44e-9 Basal cell carcinoma; CRC cis rs2842992 0.872 rs2758328 chr6:160090731 T/A cg11366901 chr6:160182831 ACAT2 0.86 11.42 0.53 1.14e-25 Age-related macular degeneration (geographic atrophy); CRC cis rs34172651 0.917 rs12923476 chr16:24798079 G/A cg06028605 chr16:24865363 SLC5A11 0.45 8.01 0.4 2.04e-14 Intelligence (multi-trait analysis); CRC cis rs9322193 0.884 rs12528279 chr6:150072028 A/C cg13206674 chr6:150067644 NUP43 0.68 10.28 0.49 1.08e-21 Lung cancer; CRC cis rs2032447 0.798 rs807212 chr6:26065621 A/G cg26028573 chr6:26043587 HIST1H2BB 0.5 7.28 0.37 2.43e-12 Intelligence (multi-trait analysis); CRC cis rs3892630 0.824 rs12327732 chr19:33221767 C/T cg22980127 chr19:33182716 NUDT19 0.91 10.87 0.51 9.82e-24 Red blood cell traits; CRC cis rs4819052 0.788 rs13049700 chr21:46701909 G/C cg02159808 chr21:46707872 POFUT2;LOC642852 0.57 7.67 0.39 1.97e-13 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC trans rs4927850 1.000 rs7614767 chr3:195753451 C/T cg16724585 chr3:197361211 NA -0.48 -7.07 -0.36 9.12e-12 Pancreatic cancer; CRC cis rs375066 0.592 rs349045 chr19:44299892 A/G cg12072164 chr19:44306565 LYPD5 -0.37 -5.86 -0.31 1.11e-8 Breast cancer; CRC cis rs873946 0.504 rs4880275 chr10:134576552 C/T cg06453172 chr10:134556979 INPP5A -0.64 -8.35 -0.42 1.87e-15 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CRC cis rs12586317 0.525 rs10144430 chr14:35433682 T/A cg05294307 chr14:35346193 BAZ1A -0.69 -8.75 -0.43 1.12e-16 Psoriasis; CRC trans rs11098499 0.697 rs4560394 chr4:120313435 T/G cg25214090 chr10:38739885 LOC399744 0.64 10.07 0.49 5.92e-21 Corneal astigmatism; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg05100916 chr7:112090586 IFRD1 0.52 6.92 0.36 2.39e-11 Thyroid stimulating hormone; CRC cis rs977987 0.806 rs8050769 chr16:75388434 C/T cg03315344 chr16:75512273 CHST6 0.52 8.74 0.43 1.22e-16 Dupuytren's disease; CRC cis rs5498 0.839 rs62130686 chr19:10408742 A/C cg10604476 chr19:10403908 ICAM5 0.3 5.66 0.3 3.3e-8 Lymphocyte counts;Soluble ICAM-1;Blood protein levels; CRC cis rs1008375 1.000 rs10939744 chr4:17664473 G/T cg16339924 chr4:17578868 LAP3 0.53 6.92 0.36 2.39e-11 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs910316 0.664 rs2098252 chr14:75492732 T/C cg03030879 chr14:75389066 RPS6KL1 -0.41 -6.21 -0.32 1.59e-9 Height; CRC cis rs2836974 0.568 rs429955 chr21:40539760 G/A cg11644478 chr21:40555479 PSMG1 0.73 12.32 0.56 6.18e-29 Cognitive function; CRC trans rs7618501 0.521 rs2352984 chr3:49948728 T/C cg21665057 chr3:196295764 WDR53;FBXO45 0.48 7.07 0.36 9.45e-12 Intelligence (multi-trait analysis); CRC trans rs10504229 1.000 rs57186557 chr8:58177277 A/G cg04077850 chr5:125800366 GRAMD3 0.37 6.27 0.33 1.15e-9 Developmental language disorder (linguistic errors); CRC cis rs59104589 0.617 rs6672 chr2:242293021 A/G cg19488206 chr2:242435732 STK25 0.47 6.81 0.35 4.76e-11 Fibrinogen levels; CRC cis rs8072100 0.713 rs2292346 chr17:45455473 G/A cg08085267 chr17:45401833 C17orf57 -0.57 -8.52 -0.42 6e-16 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs524281 0.731 rs2276036 chr11:66033430 C/T cg16950941 chr11:66035639 RAB1B -0.72 -8.16 -0.41 7.42e-15 Electroencephalogram traits; CRC cis rs10986311 0.722 rs17315546 chr9:127148229 C/T cg14243010 chr9:127117328 LOC100129034;PSMB7 0.43 6.36 0.33 6.73e-10 Vitiligo; CRC cis rs2180341 0.680 rs9388554 chr6:127576234 C/G cg27446573 chr6:127587934 RNF146 0.76 11.44 0.53 9.62e-26 Breast cancer; CRC cis rs6952808 0.500 rs3800902 chr7:2144378 C/T cg22963979 chr7:1858916 MAD1L1 -0.45 -6.57 -0.34 1.96e-10 Bipolar disorder and schizophrenia; CRC cis rs2580764 0.565 rs6760429 chr2:55228499 C/T cg09592903 chr2:55203963 RTN4 -0.74 -11.92 -0.55 1.81e-27 Mean platelet volume; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg17841782 chr1:59762205 FGGY 0.38 6.15 0.32 2.3e-9 Liver disease severity in Alagille syndrome; CRC cis rs7618915 0.547 rs11130315 chr3:52697163 A/G cg18404041 chr3:52824283 ITIH1 -0.43 -8.74 -0.43 1.21e-16 Bipolar disorder; CRC cis rs1008375 1.000 rs56308330 chr4:17643050 G/A cg16339924 chr4:17578868 LAP3 0.57 7.72 0.39 1.37e-13 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs12586317 0.547 rs112138868 chr14:35444385 C/T cg16230307 chr14:35515116 FAM177A1 0.88 10.19 0.49 2.18e-21 Psoriasis; CRC cis rs1046896 0.519 rs9900369 chr17:80829807 G/A cg19500275 chr17:80737654 TBCD 0.51 7.02 0.36 1.31e-11 Glycated hemoglobin levels; CRC cis rs875971 0.545 rs67775320 chr7:65658779 T/C cg18876405 chr7:65276391 NA 0.45 6.34 0.33 7.56e-10 Aortic root size; CRC cis rs734999 0.588 rs60520190 chr1:2533706 G/A cg20673091 chr1:2541236 MMEL1 0.36 5.84 0.31 1.26e-8 Ulcerative colitis; CRC cis rs2032447 0.639 rs198810 chr6:26128618 A/G cg12310025 chr6:25882481 NA 0.46 6.4 0.33 5.5e-10 Intelligence (multi-trait analysis); CRC cis rs7072216 0.763 rs2147901 chr10:100165496 A/C cg26618903 chr10:100175079 PYROXD2 0.51 8.53 0.43 5.5e-16 Metabolite levels; CRC cis rs7493 1.000 rs2068604 chr7:95041542 G/T cg20119798 chr7:94954144 PON1 -0.49 -6.19 -0.32 1.77e-9 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs7264396 0.635 rs6060682 chr20:34506331 G/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.6 -10.11 -0.49 4.13e-21 Total cholesterol levels; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg17236293 chr7:6865970 C7orf28B 0.39 6.05 0.32 3.97e-9 Liver disease severity in Alagille syndrome; CRC cis rs7666738 0.962 rs4699605 chr4:99064379 A/G cg03676636 chr4:99064102 C4orf37 0.22 5.91 0.31 8.46e-9 Colonoscopy-negative controls vs population controls; CRC cis rs17376456 0.877 rs10057605 chr5:93443950 T/G cg25358565 chr5:93447407 FAM172A 1.01 10.18 0.49 2.48e-21 Diabetic retinopathy; CRC cis rs10504229 0.683 rs1495866 chr8:58141128 T/C cg02725872 chr8:58115012 NA -0.64 -11.55 -0.54 3.85e-26 Developmental language disorder (linguistic errors); CRC cis rs7113874 0.610 rs10840055 chr11:8494345 C/T cg02811074 chr11:8615871 STK33 0.36 6.15 0.32 2.24e-9 Body mass index in physically active individuals;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs7246657 0.943 rs8109632 chr19:37931125 A/T cg23950597 chr19:37808831 NA -0.49 -6.09 -0.32 3.18e-9 Coronary artery calcification; CRC cis rs7072216 0.763 rs10736129 chr10:100171571 C/T cg26618903 chr10:100175079 PYROXD2 0.55 8.93 0.44 3.18e-17 Metabolite levels; CRC trans rs1493916 0.748 rs7230463 chr18:31309133 G/C cg27147174 chr7:100797783 AP1S1 -0.4 -6.69 -0.35 9.38e-11 Life satisfaction; CRC trans rs1005277 0.505 rs200939 chr10:38139483 T/C cg27523141 chr10:43048294 ZNF37B 0.44 6.45 0.34 3.89e-10 Extrinsic epigenetic age acceleration; CRC cis rs7208859 0.623 rs59447372 chr17:29057585 C/T cg13385521 chr17:29058706 SUZ12P 0.7 7.84 0.4 6.24e-14 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs4588572 0.643 rs6453391 chr5:77755035 T/C cg11446398 chr5:77624930 NA 0.46 6.24 0.33 1.37e-9 Triglycerides; CRC cis rs9341808 0.718 rs2874829 chr6:80856097 A/G cg08355045 chr6:80787529 NA 0.42 6.84 0.35 3.92e-11 Sitting height ratio; CRC cis rs9549367 0.789 rs9549705 chr13:113888425 T/C cg18105134 chr13:113819100 PROZ -0.72 -10.74 -0.51 2.8e-23 Platelet distribution width; CRC cis rs853679 1.000 rs68141011 chr6:28217797 G/T cg15845792 chr6:28175446 NA 0.73 6.86 0.35 3.38e-11 Depression; CRC cis rs6748734 0.857 rs4675857 chr2:241842326 T/C cg07537917 chr2:241836409 C2orf54 -0.21 -5.75 -0.3 2.05e-8 Urinary metabolites; CRC cis rs853679 0.517 rs9357061 chr6:28051772 A/G cg21251018 chr6:28226885 NKAPL 0.48 6.29 0.33 9.93e-10 Depression; CRC cis rs6570726 1.000 rs441477 chr6:145848243 C/T cg05347473 chr6:146136440 FBXO30 0.38 6.0 0.31 5.26e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs1865760 0.555 rs2051541 chr6:25945211 C/T cg17691542 chr6:26056736 HIST1H1C -0.39 -5.93 -0.31 7.84e-9 Height; CRC cis rs7949030 0.596 rs71490394 chr11:62370155 G/A cg13298116 chr11:62369859 EML3;MTA2 0.61 10.67 0.51 4.86e-23 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; CRC trans rs35110281 0.805 rs3788062 chr21:44991159 C/T cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.45 7.47 0.38 7.34e-13 Mean corpuscular volume; CRC cis rs13191362 1.000 rs35092540 chr6:163090778 A/G cg06582575 chr6:163149167 PACRG;PARK2 0.93 11.67 0.54 1.44e-26 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs2836950 0.565 rs8130320 chr21:40580258 C/T cg17971929 chr21:40555470 PSMG1 -0.58 -8.74 -0.43 1.2e-16 Menarche (age at onset); CRC cis rs1865760 0.963 rs9356991 chr6:25901758 C/A cg16482183 chr6:26056742 HIST1H1C 0.55 8.0 0.4 2.09e-14 Height; CRC cis rs6968419 0.747 rs3807975 chr7:115880277 G/A cg02561103 chr7:115862891 TES -0.42 -6.35 -0.33 7.09e-10 Intraocular pressure; CRC cis rs2072510 1.000 rs2072510 chr12:96403199 A/G cg22491680 chr12:96389547 HAL 0.37 5.88 0.31 1e-8 Metabolite levels (small molecules and protein measures); CRC cis rs3892630 0.878 rs7246451 chr19:33209614 C/G cg22980127 chr19:33182716 NUDT19 0.93 11.09 0.52 1.66e-24 Red blood cell traits; CRC cis rs1881396 0.945 rs1881397 chr2:27832285 A/G cg27432699 chr2:27873401 GPN1 0.55 7.23 0.37 3.37e-12 Nonalcoholic fatty liver disease; CRC cis rs7113874 0.504 rs10743081 chr11:8624100 T/G cg17679104 chr11:8615758 STK33 0.34 5.8 0.3 1.59e-8 Body mass index in physically active individuals;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs7737355 0.681 rs11242094 chr5:131072622 A/G cg25547332 chr5:131281432 NA 0.35 5.61 0.3 4.37e-8 Life satisfaction; CRC cis rs709400 0.628 rs10141120 chr14:103923008 T/C cg12935359 chr14:103987150 CKB -0.49 -7.94 -0.4 3.3e-14 Body mass index; CRC cis rs250677 0.687 rs250673 chr5:148445798 C/T cg18129178 chr5:148520854 ABLIM3 -0.36 -5.64 -0.3 3.72e-8 Breast cancer; CRC cis rs736408 0.774 rs4687551 chr3:52823448 C/T cg18099408 chr3:52552593 STAB1 0.38 5.89 0.31 9.32e-9 Bipolar disorder; CRC cis rs4481887 0.893 rs6587450 chr1:248480496 T/A cg13385794 chr1:248469461 NA 0.38 6.66 0.34 1.14e-10 Common traits (Other); CRC cis rs4713118 0.866 rs9468217 chr6:27726467 G/A cg15786705 chr6:28176104 NA 0.58 7.1 0.36 7.58e-12 Parkinson's disease; CRC cis rs7772486 0.806 rs4075695 chr6:146250959 A/G cg23711669 chr6:146136114 FBXO30 -0.66 -11.34 -0.53 2.3e-25 Lobe attachment (rater-scored or self-reported); CRC cis rs7264396 0.690 rs2425183 chr20:34450621 T/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.62 -10.28 -0.49 1.13e-21 Total cholesterol levels; CRC cis rs9399135 0.935 rs949547 chr6:135343499 C/G cg22676075 chr6:135203613 NA 0.41 6.38 0.33 5.97e-10 Red blood cell count; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg25428213 chr17:80929211 B3GNTL1 -0.39 -6.28 -0.33 1.06e-9 Liver disease severity in Alagille syndrome; CRC cis rs1862618 0.853 rs33326 chr5:56142601 G/A cg24531977 chr5:56204891 C5orf35 -0.82 -10.96 -0.52 4.91e-24 Initial pursuit acceleration; CRC cis rs2274273 0.714 rs7154889 chr14:55806885 G/A cg23234261 chr14:55582407 NA -0.29 -5.81 -0.31 1.47e-8 Protein biomarker; CRC trans rs867371 0.502 rs3759800 chr15:82532963 A/C cg04831495 chr15:85060580 GOLGA6L5 0.39 6.09 0.32 3.14e-9 Cognitive ability;Cognitive ability (multi-trait analysis); CRC cis rs11785400 0.928 rs750529 chr8:143744877 G/C cg24634471 chr8:143751801 JRK 0.53 7.54 0.38 4.55e-13 Schizophrenia; CRC cis rs10489202 0.632 rs203781 chr1:167880518 A/C cg24449463 chr1:168025552 DCAF6 -0.6 -8.98 -0.44 2.06e-17 Schizophrenia; CRC cis rs514406 0.861 rs1749907 chr1:53259658 C/T cg24675658 chr1:53192096 ZYG11B 0.56 8.16 0.41 6.94e-15 Monocyte count; CRC cis rs3741404 0.560 rs2875748 chr11:63915537 G/A cg06219103 chr11:63990595 FERMT3 0.48 7.69 0.39 1.73e-13 Platelet count; CRC cis rs174601 0.668 rs174559 chr11:61581656 G/A cg06781209 chr11:61594997 FADS2 -0.43 -5.97 -0.31 6.27e-9 Blood metabolite levels;Red blood cell fatty acid levels;Liver enzyme levels (alkaline phosphatase);Gondoic acid (20:1n-9) levels;Trans fatty acid levels; CRC cis rs9467711 0.606 rs2072803 chr6:26392515 G/C cg14345882 chr6:26364793 BTN3A2 0.77 6.28 0.33 1.04e-9 Autism spectrum disorder or schizophrenia; CRC cis rs10504229 0.861 rs6990617 chr8:58182960 G/T cg02725872 chr8:58115012 NA -0.38 -6.43 -0.33 4.44e-10 Developmental language disorder (linguistic errors); CRC cis rs514406 0.893 rs479569 chr1:53352407 C/T cg24675658 chr1:53192096 ZYG11B -0.57 -8.24 -0.41 4.19e-15 Monocyte count; CRC cis rs17666538 1.000 rs59631161 chr8:587808 G/T cg07234876 chr8:600039 NA -0.93 -8.14 -0.41 8.53e-15 IgG glycosylation; CRC trans rs7395662 1.000 rs4882021 chr11:48615966 G/C cg21153622 chr11:89784906 NA -0.48 -7.68 -0.39 1.78e-13 HDL cholesterol; CRC cis rs1401999 1.000 rs6804242 chr3:183659463 A/T cg01324343 chr3:183735012 ABCC5 0.81 14.75 0.63 3.71e-38 Anterior chamber depth; CRC cis rs28655083 0.529 rs662101 chr16:77105405 G/T cg01753188 chr16:77233325 SYCE1L;MON1B -0.47 -6.7 -0.35 9.02e-11 Lobe attachment (rater-scored or self-reported); CRC cis rs4665809 1.000 rs10182857 chr2:26344411 C/T cg04944784 chr2:26401820 FAM59B -0.6 -7.67 -0.39 1.98e-13 Gut microbiome composition (summer); CRC cis rs853679 0.517 rs9380055 chr6:28081629 A/G cg18032046 chr6:28092343 ZSCAN16 -0.52 -6.02 -0.31 4.76e-9 Depression; CRC cis rs1976403 0.510 rs1697421 chr1:21823292 C/T cg02390115 chr1:21767211 NBPF3 0.46 6.75 0.35 6.81e-11 Liver enzyme levels (alkaline phosphatase); CRC cis rs2836974 0.568 rs2836969 chr21:40648265 G/A cg11644478 chr21:40555479 PSMG1 -0.7 -11.4 -0.53 1.35e-25 Cognitive function; CRC trans rs3743266 0.613 rs2414669 chr15:60708824 A/G cg02181963 chr13:111358803 CARS2 0.4 6.03 0.32 4.45e-9 Menarche (age at onset); CRC trans rs7267979 0.903 rs6115118 chr20:25246734 G/A cg17903999 chr18:56338584 MALT1 -0.41 -6.49 -0.34 3.23e-10 Liver enzyme levels (alkaline phosphatase); CRC cis rs7177699 0.526 rs7166764 chr15:79123509 T/G cg15571903 chr15:79123663 NA 0.34 6.81 0.35 4.58e-11 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; CRC cis rs4862750 0.872 rs9998172 chr4:187898773 T/C cg03647317 chr4:187891568 NA -0.55 -10.22 -0.49 1.83e-21 Lobe attachment (rater-scored or self-reported); CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg23058613 chr11:62414236 GANAB 0.5 6.51 0.34 2.83e-10 Anxiety disorder; CRC cis rs877282 0.891 rs34383514 chr10:800181 T/C cg17470449 chr10:769945 NA 0.68 9.06 0.45 1.2e-17 Uric acid levels; CRC cis rs898097 0.585 rs9892342 chr17:80893029 C/T cg15369054 chr17:80825471 TBCD -0.36 -5.91 -0.31 8.45e-9 Breast cancer; CRC cis rs7917772 0.503 rs61871067 chr10:104295382 C/T cg22532475 chr10:104410764 TRIM8 -0.42 -7.06 -0.36 9.93e-12 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC trans rs944990 0.595 rs10123378 chr9:96375217 C/T cg13953403 chr8:38034403 LSM1;BAG4 0.4 6.07 0.32 3.53e-9 Body mass index; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg27054524 chr16:19097807 NA 0.49 7.06 0.36 1.02e-11 Response to antipsychotic treatment; CRC cis rs7829975 0.540 rs2976909 chr8:8346690 C/T cg14979609 chr8:8086686 FLJ10661 0.38 5.82 0.31 1.41e-8 Mood instability; CRC trans rs3733585 0.699 rs6834893 chr4:9959123 C/T cg26043149 chr18:55253948 FECH -0.5 -7.62 -0.39 2.81e-13 Cleft plate (environmental tobacco smoke interaction); CRC cis rs8077889 0.719 rs2079006 chr17:41865745 C/G cg25876840 chr17:41920477 NA 0.4 6.42 0.33 4.82e-10 Triglycerides; CRC cis rs769267 1.000 rs769267 chr19:19446936 A/G cg03709012 chr19:19516395 GATAD2A 0.67 10.32 0.49 8.27e-22 Tonsillectomy; CRC cis rs3749237 0.595 rs4855861 chr3:49525962 G/T cg07636037 chr3:49044803 WDR6 0.56 8.03 0.4 1.72e-14 Resting heart rate; CRC cis rs736801 0.607 rs11739135 chr5:131733397 C/G cg12564285 chr5:131593104 PDLIM4 0.35 5.87 0.31 1.06e-8 Breast cancer;Mosquito bite size; CRC cis rs870825 0.929 rs871253 chr4:185589234 G/A cg04058563 chr4:185651563 MLF1IP 0.64 6.6 0.34 1.6e-10 Blood protein levels; CRC cis rs7632954 0.669 rs9879912 chr3:8527801 C/T cg03495237 chr3:8533978 NA 0.35 6.55 0.34 2.21e-10 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs9355610 0.727 rs2247315 chr6:167370211 A/C cg23791538 chr6:167370224 RNASET2 0.58 9.62 0.47 1.83e-19 Graves' disease; CRC cis rs875971 0.800 rs427557 chr7:65519250 A/G cg18912574 chr7:65842487 NCRNA00174 0.38 6.49 0.34 3.22e-10 Aortic root size; CRC cis rs3820928 0.647 rs2115597 chr2:227791218 T/C cg11843606 chr2:227700838 RHBDD1 -0.45 -6.85 -0.35 3.62e-11 Pulmonary function; CRC cis rs703842 0.739 rs701008 chr12:58117645 A/G cg00677455 chr12:58241039 CTDSP2 0.48 6.62 0.34 1.47e-10 Multiple sclerosis; CRC cis rs58688157 0.705 rs2396545 chr11:601785 T/C cg07212818 chr11:638076 DRD4 -0.43 -5.77 -0.3 1.81e-8 Systemic lupus erythematosus; CRC cis rs3816788 0.774 rs11784816 chr8:21773500 C/T cg17168535 chr8:21777572 XPO7 -0.57 -9.5 -0.46 4.66e-19 Lung cancer in ever smokers; CRC cis rs3204270 0.639 rs62080213 chr17:79642531 C/T cg18367735 chr17:79674897 NA 0.5 5.77 0.3 1.88e-8 Dental caries; CRC cis rs172166 0.637 rs1225595 chr6:28151340 A/T cg17949981 chr6:28129498 ZNF389 0.41 5.71 0.3 2.54e-8 Cardiac Troponin-T levels; CRC cis rs4819052 1.000 rs4818769 chr21:46667451 C/T cg02159808 chr21:46707872 POFUT2;LOC642852 0.62 7.51 0.38 5.67e-13 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs344364 0.629 rs9806826 chr16:1894912 C/T cg14074117 chr16:1909714 C16orf73 0.34 5.95 0.31 6.71e-9 Glomerular filtration rate in chronic kidney disease; CRC cis rs9858542 0.953 rs9859556 chr3:49455986 G/T cg07274523 chr3:49395745 GPX1 0.47 6.32 0.33 8.64e-10 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs6963495 0.932 rs55700120 chr7:105148460 G/T cg13798780 chr7:105162888 PUS7 0.66 8.06 0.41 1.39e-14 Bipolar disorder (body mass index interaction); CRC cis rs372883 0.600 rs2832298 chr21:30743863 C/G cg08807101 chr21:30365312 RNF160 0.57 8.16 0.41 7.18e-15 Pancreatic cancer; CRC cis rs1007738 0.579 rs61896136 chr11:47120299 C/A cg19486271 chr11:47235900 DDB2 0.44 5.89 0.31 9.76e-9 Bone mineral density (hip); CRC cis rs7512552 0.839 rs834229 chr1:150384665 G/C cg15654264 chr1:150340011 RPRD2 0.6 8.46 0.42 9.15e-16 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); CRC cis rs3768617 0.811 rs4350171 chr1:182982148 C/T ch.1.3577855R chr1:183094577 LAMC1 0.61 8.98 0.44 2.15e-17 Fuchs's corneal dystrophy; CRC cis rs11608355 0.545 rs9943764 chr12:109905720 G/A cg05360138 chr12:110035743 NA 0.77 8.7 0.43 1.65e-16 Neuroticism; CRC cis rs2274273 0.870 rs10147434 chr14:55674847 C/T cg23234261 chr14:55582407 NA -0.29 -5.73 -0.3 2.28e-8 Protein biomarker; CRC cis rs2535633 0.631 rs2336670 chr3:52998504 T/G cg11645453 chr3:52864694 ITIH4 -0.4 -7.51 -0.38 5.64e-13 Body mass index; CRC cis rs2569991 0.636 rs9211 chr3:12939546 A/G cg22481960 chr3:13008800 IQSEC1 0.49 6.42 0.33 4.73e-10 Periodontitis (DPAL); CRC cis rs3806843 1.000 rs1548699 chr5:140164918 T/C cg19875535 chr5:140030758 IK 0.6 9.79 0.48 4.86e-20 Depressive symptoms (multi-trait analysis); CRC cis rs738322 0.533 rs5756934 chr22:38547279 G/A cg25457927 chr22:38595422 NA -0.37 -7.4 -0.38 1.18e-12 Cutaneous nevi; CRC cis rs68170813 0.559 rs78404515 chr7:106909126 G/A cg02696742 chr7:106810147 HBP1 -0.61 -6.7 -0.35 9.26e-11 Coronary artery disease; CRC cis rs6951245 1.000 rs77702926 chr7:1088838 G/A cg04025307 chr7:1156635 C7orf50 0.64 6.66 0.34 1.16e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs514406 0.689 rs7548389 chr1:53404211 C/T cg25767906 chr1:53392781 SCP2 -0.51 -8.19 -0.41 5.78e-15 Monocyte count; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg21652107 chr4:48782392 FRYL 0.44 6.21 0.32 1.63e-9 Response to antipsychotic treatment; CRC cis rs1448094 0.512 rs4362214 chr12:86245145 C/T cg02569458 chr12:86230093 RASSF9 0.42 7.24 0.37 3.17e-12 Major depressive disorder; CRC cis rs6570726 0.837 rs636894 chr6:145864122 T/C cg05347473 chr6:146136440 FBXO30 0.4 6.24 0.33 1.34e-9 Lobe attachment (rater-scored or self-reported); CRC trans rs4650994 0.525 rs2493864 chr1:178545003 A/C cg05059571 chr16:84539110 KIAA1609 -0.56 -7.76 -0.39 1.05e-13 HDL cholesterol levels;HDL cholesterol; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg22087953 chr7:45847100 NA -0.4 -6.44 -0.33 4.15e-10 Liver disease severity in Alagille syndrome; CRC cis rs4700695 0.719 rs153390 chr5:65431087 G/C cg21114390 chr5:65439923 SFRS12 -0.63 -8.46 -0.42 8.74e-16 Facial morphology (factor 19); CRC cis rs968567 0.705 rs174573 chr11:61600327 G/A cg19610905 chr11:61596333 FADS2 -0.42 -6.03 -0.32 4.3e-9 Blood metabolite levels;Rheumatoid arthritis;Vitiligo;Glycerophospholipid levels; CRC cis rs1153858 1.000 rs1980288 chr15:45620612 T/C cg10760299 chr15:45669010 GATM 0.51 8.12 0.41 9.73e-15 Homoarginine levels; CRC cis rs1046896 0.520 rs8074086 chr17:80818460 A/C cg08200770 chr17:80723486 TBCD -0.48 -7.42 -0.38 9.91e-13 Glycated hemoglobin levels; CRC cis rs477895 0.652 rs72920332 chr11:63947071 G/T cg04317338 chr11:64019027 PLCB3 0.61 7.42 0.38 9.81e-13 Mean platelet volume; CRC cis rs2976388 0.609 rs2572899 chr8:143785549 A/G cg24046110 chr8:143859143 LYNX1 0.49 8.57 0.43 4.11e-16 Urinary tract infection frequency; CRC cis rs7811142 0.830 rs61735533 chr7:99955866 G/A cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.11 15.96 0.66 7.52e-43 Platelet count; CRC cis rs1129187 0.719 rs3805953 chr6:42936900 C/T cg09436375 chr6:42928200 GNMT -0.34 -6.17 -0.32 2.05e-9 Alzheimer's disease in APOE e4+ carriers; CRC cis rs28374715 0.662 rs113913466 chr15:41483100 A/G cg18705301 chr15:41695430 NDUFAF1 -0.93 -13.84 -0.61 1.25e-34 Ulcerative colitis; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg25411849 chr6:89855994 PM20D2 -0.41 -6.17 -0.32 2e-9 Myopia (pathological); CRC cis rs2050392 0.624 rs303435 chr10:30731491 T/C cg18806716 chr10:30721971 MAP3K8 -0.71 -10.58 -0.5 1.06e-22 Inflammatory bowel disease; CRC cis rs9892942 1 rs9892942 chr17:27178761 C/T cg16670446 chr17:27188758 MIR451;MIR144 0.6 9.71 0.47 9.02e-20 Mean corpuscular volume;Mean corpuscular hemoglobin; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg24274600 chr5:95066816 RHOBTB3 0.46 6.68 0.35 1e-10 Intelligence (multi-trait analysis); CRC cis rs1552244 0.572 rs12107622 chr3:10171898 T/A cg13047869 chr3:10149882 C3orf24 0.55 6.66 0.34 1.17e-10 Alzheimer's disease; CRC cis rs3889199 0.924 rs12752853 chr1:59668705 C/T cg25881383 chr1:59680599 NA -0.38 -6.11 -0.32 2.82e-9 Pulse pressure; CRC cis rs1451375 0.741 rs55738142 chr7:50632326 T/C cg14593290 chr7:50529359 DDC 0.53 7.26 0.37 2.76e-12 Malaria; CRC cis rs7589728 0.563 rs78685993 chr2:88447026 T/C cg07952391 chr2:88470173 THNSL2 0.69 7.1 0.36 7.77e-12 Plasma clusterin levels; CRC cis rs9787249 0.874 rs12094291 chr1:40226046 G/A cg19912559 chr1:40204330 PPIE 0.52 7.64 0.39 2.39e-13 Blood protein levels; CRC cis rs7945705 0.747 rs2568045 chr11:9004060 T/C cg21881798 chr11:8931708 C11orf17;ST5 -0.7 -12.26 -0.56 1e-28 Hemoglobin concentration; CRC cis rs10540 1.000 rs78520676 chr11:517173 G/A cg15790184 chr11:494944 RNH1 0.61 6.25 0.33 1.27e-9 Body mass index; CRC trans rs561341 0.941 rs501773 chr17:30314435 T/G cg20587970 chr11:113659929 NA -1.18 -17.29 -0.69 4.03e-48 Hip circumference adjusted for BMI; CRC cis rs2625529 0.586 rs11639282 chr15:72435260 G/A cg16672083 chr15:72433130 SENP8 0.4 6.09 0.32 3.13e-9 Red blood cell count; CRC cis rs10992471 0.580 rs7847534 chr9:95282653 C/T cg14631576 chr9:95140430 CENPP -0.39 -6.76 -0.35 6.18e-11 Visceral adipose tissue/subcutaneous adipose tissue ratio; CRC cis rs11025559 0.796 rs11603462 chr11:20412180 C/A cg19653624 chr11:20408972 PRMT3 -0.63 -7.69 -0.39 1.76e-13 Pursuit maintenance gain; CRC cis rs875971 0.540 rs781152 chr7:65479572 T/A cg11764359 chr7:65958608 NA 0.52 7.67 0.39 2e-13 Aortic root size; CRC trans rs3743266 0.613 rs2414669 chr15:60708824 A/G cg19590674 chr17:25783100 NA 0.42 6.44 0.33 4.19e-10 Menarche (age at onset); CRC cis rs1448094 0.512 rs6539931 chr12:86247473 C/T cg02569458 chr12:86230093 RASSF9 0.43 7.41 0.38 1.06e-12 Major depressive disorder; CRC cis rs9611565 0.694 rs202665 chr22:41814401 A/G cg06634786 chr22:41940651 POLR3H 0.62 7.12 0.37 6.85e-12 Vitiligo; CRC cis rs9487051 0.702 rs670414 chr6:109529912 A/G cg21918786 chr6:109611834 NA 0.35 5.87 0.31 1.06e-8 Reticulocyte fraction of red cells; CRC trans rs2303319 0.504 rs62189043 chr2:162608466 A/T cg22627826 chr19:1240265 ATP5D -0.72 -6.24 -0.33 1.32e-9 Cognitive function; CRC cis rs77861329 1.000 rs55834589 chr3:52081724 C/T cg08692210 chr3:52188851 WDR51A 0.82 6.9 0.36 2.73e-11 Macrophage inflammatory protein 1b levels; CRC cis rs2979489 0.945 rs11993146 chr8:30319537 G/A cg26383811 chr8:30366931 RBPMS -0.68 -9.72 -0.47 8.49e-20 Mean corpuscular hemoglobin;Plateletcrit;Neutrophil count;Granulocyte count;Sum basophil neutrophil counts;Mean corpuscular volume;Myeloid white cell count;Sum neutrophil eosinophil counts; CRC cis rs3768617 0.510 rs2027075 chr1:183073266 A/G ch.1.3577855R chr1:183094577 LAMC1 0.85 14.84 0.63 1.74e-38 Fuchs's corneal dystrophy; CRC trans rs2243480 1.000 rs316330 chr7:65605372 C/A cg10756647 chr7:56101905 PSPH 0.72 7.51 0.38 5.66e-13 Diabetic kidney disease; CRC cis rs425277 0.583 rs4648807 chr1:2040898 A/G cg04315214 chr1:2043799 PRKCZ 0.46 8.27 0.41 3.43e-15 Height; CRC trans rs57221529 0.709 rs72703090 chr5:598314 C/T cg11887960 chr12:57824829 NA 0.59 6.66 0.34 1.15e-10 Lung disease severity in cystic fibrosis; CRC cis rs7927771 0.800 rs12146565 chr11:47398963 G/A cg05585544 chr11:47624801 NA -0.56 -10.06 -0.49 6.22e-21 Subjective well-being; CRC cis rs68170813 0.523 rs79619227 chr7:107025335 T/C cg02696742 chr7:106810147 HBP1 -0.57 -5.9 -0.31 9.01e-9 Coronary artery disease; CRC cis rs5758265 1 rs5758265 chr22:41617897 G/A cg03806693 chr22:41940476 POLR3H -0.51 -6.67 -0.35 1.09e-10 Depressive symptoms (multi-trait analysis); CRC cis rs9910055 0.530 rs8072954 chr17:42294722 G/A cg13607699 chr17:42295918 UBTF 0.81 14.41 0.62 8.01e-37 Total body bone mineral density; CRC cis rs12024301 0.557 rs12041485 chr1:183591526 C/A cg11505048 chr1:183622726 RGL1;APOBEC4 0.76 6.93 0.36 2.16e-11 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs6952808 1.000 rs10260585 chr7:1889521 G/A cg04267008 chr7:1944627 MAD1L1 -0.77 -11.15 -0.52 1.08e-24 Bipolar disorder and schizophrenia; CRC trans rs7937682 0.924 rs7924683 chr11:111555796 C/A cg18187862 chr3:45730750 SACM1L 0.46 6.7 0.35 8.95e-11 Primary sclerosing cholangitis; CRC cis rs67311347 0.869 rs6790495 chr3:40366770 C/T cg09455208 chr3:40491958 NA 0.39 7.45 0.38 8.13e-13 Renal cell carcinoma; CRC cis rs10791323 0.604 rs2723605 chr11:133711241 C/G cg00579200 chr11:133705235 NA -0.4 -5.92 -0.31 8.18e-9 Childhood ear infection; CRC cis rs4713118 0.539 rs200967 chr6:27862127 A/G cg20933634 chr6:27740509 NA 0.5 7.0 0.36 1.47e-11 Parkinson's disease; CRC cis rs3858526 0.584 rs10769276 chr11:5868020 G/T cg02574844 chr11:5959923 NA -0.52 -7.52 -0.38 5.24e-13 DNA methylation (variation); CRC cis rs11098499 0.821 rs28665282 chr4:120384186 C/T cg24375607 chr4:120327624 NA 0.5 7.72 0.39 1.4e-13 Corneal astigmatism; CRC cis rs7917772 0.503 rs7896841 chr10:104294665 C/T cg22532475 chr10:104410764 TRIM8 -0.36 -6.62 -0.34 1.43e-10 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC cis rs10504229 0.683 rs2101864 chr8:58113226 C/T cg04204079 chr8:58130323 NA -0.46 -5.84 -0.31 1.22e-8 Developmental language disorder (linguistic errors); CRC cis rs6831352 0.703 rs2602862 chr4:100033221 A/G cg12011299 chr4:100065546 ADH4 0.45 8.75 0.43 1.1e-16 Alcohol dependence; CRC trans rs877282 0.583 rs11595057 chr10:819203 A/C cg22713356 chr15:30763199 NA 0.72 8.61 0.43 3.04e-16 Uric acid levels; CRC cis rs9969804 0.782 rs912262 chr9:95525557 C/T cg14631576 chr9:95140430 CENPP 0.31 5.67 0.3 3.07e-8 Height; CRC cis rs1552244 1.000 rs17032283 chr3:10081545 C/G cg02579736 chr3:10068473 FANCD2;CIDECP 1.07 14.7 0.63 5.81e-38 Alzheimer's disease; CRC cis rs1046896 0.561 rs8076476 chr17:80861017 A/C cg19500275 chr17:80737654 TBCD 0.53 7.28 0.37 2.56e-12 Glycated hemoglobin levels; CRC cis rs600626 0.636 rs11236518 chr11:75453066 C/T cg24262691 chr11:75473276 NA 0.49 6.77 0.35 5.94e-11 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CRC trans rs17685 0.712 rs4552844 chr7:75718095 A/G cg19862616 chr7:65841803 NCRNA00174 0.99 18.51 0.71 6.2e-53 Coffee consumption;Coffee consumption (cups per day); CRC cis rs172166 0.694 rs203892 chr6:28067196 T/C cg06470822 chr6:28175283 NA 0.82 12.25 0.56 1.14e-28 Cardiac Troponin-T levels; CRC cis rs477895 0.653 rs7102327 chr11:63908720 C/T cg04317338 chr11:64019027 PLCB3 0.59 7.31 0.37 2.02e-12 Mean platelet volume; CRC cis rs9303280 0.936 rs907091 chr17:37921742 A/G cg11212589 chr17:38028394 ZPBP2 0.43 7.94 0.4 3.32e-14 Self-reported allergy; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg16150678 chr8:101170369 SPAG1 0.43 7.35 0.38 1.57e-12 Liver disease severity in Alagille syndrome; CRC cis rs7523050 0.643 rs12741194 chr1:109400390 T/C cg08274380 chr1:109419600 GPSM2 0.84 6.6 0.34 1.69e-10 Fat distribution (HIV); CRC cis rs11971779 0.715 rs7779390 chr7:139112953 C/T cg23387468 chr7:139079360 LUC7L2 0.41 7.04 0.36 1.14e-11 Diisocyanate-induced asthma; CRC trans rs9858542 1.000 rs6770670 chr3:49686682 T/C cg21582582 chr3:182698605 DCUN1D1 -0.58 -7.1 -0.36 7.97e-12 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs2302190 0.882 rs9901693 chr17:56606915 C/T cg25885038 chr17:56607967 SEPT4 -0.51 -7.76 -0.39 1.11e-13 Vitamin D levels; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg27226861 chr4:71705278 GRSF1 0.4 6.64 0.34 1.27e-10 Liver disease severity in Alagille syndrome; CRC cis rs6570726 0.791 rs370112 chr6:145859853 T/G cg05347473 chr6:146136440 FBXO30 0.39 5.85 0.31 1.21e-8 Lobe attachment (rater-scored or self-reported); CRC cis rs739401 0.572 rs739399 chr11:3016452 A/G cg08508325 chr11:3079039 CARS -0.49 -9.21 -0.45 3.85e-18 Longevity; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg21717879 chr19:572359 BSG 0.38 6.19 0.32 1.78e-9 Liver disease severity in Alagille syndrome; CRC cis rs921968 0.565 rs6436082 chr2:219639430 A/G cg02176678 chr2:219576539 TTLL4 -0.41 -6.52 -0.34 2.65e-10 Mean corpuscular hemoglobin concentration; CRC cis rs6032067 0.852 rs17424751 chr20:43814622 T/C cg10761708 chr20:43804764 PI3 0.5 5.69 0.3 2.77e-8 Blood protein levels; CRC cis rs1018836 0.847 rs2285231 chr8:91545387 G/T cg16814680 chr8:91681699 NA -0.75 -12.45 -0.57 1.99e-29 Ejection fraction in Tripanosoma cruzi seropositivity; CRC cis rs4713118 0.824 rs2179095 chr6:27750858 A/G cg21204522 chr6:27730016 NA 0.42 5.7 0.3 2.63e-8 Parkinson's disease; CRC cis rs561341 0.883 rs7219239 chr17:30212016 A/G cg23018236 chr17:30244563 NA 0.53 6.72 0.35 7.79e-11 Hip circumference adjusted for BMI; CRC cis rs7811142 1.000 rs11771419 chr7:99988403 A/G cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.74 10.08 0.49 5.16e-21 Platelet count; CRC cis rs7659604 0.539 rs3217753 chr4:122746325 A/G cg20573242 chr4:122745356 CCNA2 0.58 8.86 0.44 5.21e-17 Type 2 diabetes; CRC cis rs55702914 0.809 rs2376407 chr2:198183465 A/G cg10820045 chr2:198174542 NA -0.48 -8.98 -0.44 2.14e-17 Major depression and alcohol dependence; CRC cis rs977987 0.778 rs4888426 chr16:75476451 G/A cg03315344 chr16:75512273 CHST6 0.55 9.35 0.46 1.39e-18 Dupuytren's disease; CRC trans rs9858542 0.953 rs9878943 chr3:49434654 G/A cg21659725 chr3:3221576 CRBN -0.65 -8.94 -0.44 2.92e-17 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs4400599 0.549 rs12044616 chr1:154189417 G/A cg26808167 chr1:154192205 UBAP2L;C1orf43 -0.36 -5.76 -0.3 1.91e-8 Platelet distribution width; CRC cis rs4713118 0.869 rs9461400 chr6:27700559 A/G cg20933634 chr6:27740509 NA 0.58 8.5 0.42 6.74e-16 Parkinson's disease; CRC cis rs62064224 0.593 rs916663 chr17:30835833 A/C cg24550644 chr17:30846204 MYO1D 0.42 7.15 0.37 5.57e-12 Schizophrenia; CRC cis rs6089584 0.925 rs35683654 chr20:60625401 G/T cg23463467 chr20:60627584 TAF4 -0.37 -5.99 -0.31 5.39e-9 Body mass index; CRC cis rs7772486 0.875 rs10457796 chr6:146416087 T/G cg23711669 chr6:146136114 FBXO30 0.65 11.2 0.53 7.09e-25 Lobe attachment (rater-scored or self-reported); CRC cis rs4523957 0.690 rs4790884 chr17:2105299 G/C cg16513277 chr17:2031491 SMG6 -0.52 -8.54 -0.43 5.01e-16 Autism spectrum disorder or schizophrenia;Schizophrenia; CRC cis rs12997796 0.556 rs13004867 chr2:86982504 C/G cg25203885 chr2:87302643 LOC285074 -0.58 -6.0 -0.31 5.23e-9 Schizophrenia; CRC cis rs2549003 1.000 rs2548999 chr5:131831058 G/T cg21138405 chr5:131827807 IRF1 -0.59 -11.61 -0.54 2.33e-26 Asthma (sex interaction); CRC cis rs7727544 0.570 rs7701237 chr5:131534381 C/T cg12564285 chr5:131593104 PDLIM4 0.32 5.6 0.3 4.47e-8 Blood metabolite levels; CRC cis rs17711722 0.510 rs11767457 chr7:65290615 C/T cg02869306 chr7:64672164 INTS4L1 -0.43 -7.07 -0.36 9.61e-12 Calcium levels; CRC cis rs7103648 0.712 rs10838703 chr11:47422861 C/G cg20307385 chr11:47447363 PSMC3 0.84 12.01 0.55 8.66e-28 Diastolic blood pressure;Systolic blood pressure; CRC cis rs56146971 0.703 rs76533089 chr14:91863973 G/T cg16433844 chr14:91963127 SMEK1 -0.59 -6.12 -0.32 2.7e-9 Alzheimer disease and age of onset; CRC cis rs3806843 0.868 rs2531352 chr5:140119534 A/G cg19875535 chr5:140030758 IK -0.54 -8.69 -0.43 1.79e-16 Depressive symptoms (multi-trait analysis); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg01154849 chr17:16343053 NCRNA00188;SNORD65;SNORD49A 0.41 5.98 0.31 5.82e-9 Liver disease severity in Alagille syndrome; CRC trans rs561341 1.000 rs530209 chr17:30315287 A/G cg20587970 chr11:113659929 NA -1.43 -20.51 -0.75 8.67e-61 Hip circumference adjusted for BMI; CRC cis rs741668 0.931 rs61953335 chr13:46598816 G/A cg06018095 chr13:46550134 ZC3H13 0.42 5.91 0.31 8.45e-9 Cerebrospinal fluid clusterin levels; CRC cis rs10540 1.000 rs116101630 chr11:506826 G/C cg03576123 chr11:487126 PTDSS2 -1.05 -10.95 -0.52 5.21e-24 Body mass index; CRC cis rs9517320 1.000 rs9517322 chr13:99126338 C/G cg07423050 chr13:99094983 FARP1 0.41 6.54 0.34 2.37e-10 Longevity; CRC cis rs7408868 1.000 rs10406754 chr19:15274201 T/A cg14696996 chr19:15285081 NOTCH3 0.97 8.99 0.44 1.99e-17 Pulse pressure; CRC cis rs9517320 0.515 rs72646416 chr13:99232916 C/G cg20487152 chr13:99095054 FARP1 -0.46 -6.59 -0.34 1.71e-10 Longevity; CRC cis rs11252926 0.574 rs10904065 chr10:423226 G/T cg16386425 chr10:429943 DIP2C 0.44 5.73 0.3 2.25e-8 Psychosis in Alzheimer's disease; CRC cis rs1062746 0.545 rs3815947 chr16:87359648 C/T cg02258303 chr16:87377426 FBXO31 -0.53 -7.4 -0.38 1.12e-12 Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 2 peripheral neuropathy); CRC cis rs597539 0.690 rs635529 chr11:68626294 C/T cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.85 13.32 0.59 1.13e-32 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC trans rs1814175 0.817 rs4881645 chr11:49791168 G/A cg15704280 chr7:45808275 SEPT13 -1.01 -20.35 -0.75 3.57e-60 Height; CRC cis rs597539 0.652 rs602805 chr11:68662076 A/T cg04772025 chr11:68637568 NA 0.48 7.38 0.38 1.32e-12 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs7772486 0.754 rs6922507 chr6:146250155 A/T cg13319975 chr6:146136371 FBXO30 0.44 6.62 0.34 1.49e-10 Lobe attachment (rater-scored or self-reported); CRC cis rs35306767 0.761 rs11253559 chr10:1044809 T/C cg20503657 chr10:835505 NA 0.92 11.13 0.52 1.19e-24 Eosinophil percentage of granulocytes; CRC trans rs1973993 0.717 rs55650017 chr1:96952142 G/A cg10631902 chr5:14652156 NA -0.41 -6.82 -0.35 4.39e-11 Weight; CRC cis rs875971 1.000 rs12533997 chr7:65965377 A/G cg00343986 chr7:65444356 GUSB 0.44 6.47 0.34 3.56e-10 Aortic root size; CRC cis rs2075371 0.611 rs62462979 chr7:134019379 G/T cg20476274 chr7:133979776 SLC35B4 0.54 8.01 0.4 1.97e-14 Mean platelet volume; CRC cis rs77633900 0.892 rs1810348 chr15:76632487 C/T cg05412396 chr15:76631569 ISL2 -0.44 -5.79 -0.3 1.65e-8 Non-glioblastoma glioma;Glioma; CRC cis rs4665809 0.759 rs62128394 chr2:26364026 T/G cg27170947 chr2:26402098 FAM59B 0.56 6.13 0.32 2.57e-9 Gut microbiome composition (summer); CRC cis rs2067615 0.507 rs10746063 chr12:107086240 G/T cg13491945 chr12:107078410 RFX4 0.37 6.29 0.33 9.86e-10 Heart rate; CRC cis rs1881797 0.872 rs12404733 chr1:247690417 A/C cg11166453 chr1:247681781 NA 0.42 6.95 0.36 1.94e-11 Acute lymphoblastic leukemia (childhood); CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg02959429 chr17:27916858 GIT1 0.48 6.47 0.34 3.63e-10 Anxiety disorder; CRC cis rs17601876 0.814 rs28637352 chr15:51559666 C/A cg19946085 chr15:51559439 CYP19A1 -0.34 -6.97 -0.36 1.74e-11 Estrone/androstenedione ratio in resected early stage-receptor positive breast cancer; CRC cis rs2404602 0.692 rs7350777 chr15:76985441 G/A cg23625390 chr15:77176239 SCAPER 0.5 7.35 0.38 1.63e-12 Blood metabolite levels; CRC cis rs10256972 0.591 rs6968988 chr7:1169619 A/G cg03188948 chr7:1209495 NA 0.47 7.02 0.36 1.27e-11 Longevity;Endometriosis; CRC cis rs477895 0.653 rs2875749 chr11:63903878 C/A cg04317338 chr11:64019027 PLCB3 0.6 7.28 0.37 2.53e-12 Mean platelet volume; CRC cis rs2976388 0.609 rs2585152 chr8:143786214 A/T cg04969067 chr8:143858791 LYNX1 0.44 7.51 0.38 5.62e-13 Urinary tract infection frequency; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg03583812 chr2:61244620 PEX13;PUS10 0.49 6.98 0.36 1.64e-11 Response to antipsychotic treatment; CRC cis rs877282 0.898 rs71489279 chr10:760510 T/C cg06581033 chr10:766294 NA -0.52 -5.87 -0.31 1.04e-8 Uric acid levels; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg22682864 chr1:111326110 NA 0.48 6.41 0.33 4.99e-10 Thyroid stimulating hormone; CRC cis rs1008375 1.000 rs10009541 chr4:17682218 C/T cg16339924 chr4:17578868 LAP3 -0.53 -7.08 -0.36 8.56e-12 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs897080 0.552 rs1085442 chr2:44635454 C/A cg04920474 chr2:44395004 PPM1B 0.42 5.82 0.31 1.37e-8 Height; CRC cis rs3736485 0.966 rs28376817 chr15:51889280 A/T cg08986416 chr15:51914746 DMXL2 -0.46 -6.46 -0.34 3.75e-10 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs7937682 0.924 rs10891286 chr11:111532691 C/G cg19812747 chr11:111475976 SIK2 -0.57 -9.89 -0.48 2.34e-20 Primary sclerosing cholangitis; CRC cis rs7945718 0.810 rs7930282 chr11:12835941 C/T cg25843174 chr11:12811716 TEAD1 0.5 9.32 0.46 1.72e-18 Educational attainment (years of education); CRC cis rs6912958 0.781 rs9444524 chr6:88311260 T/C cg12350822 chr6:88032061 C6orf162;GJB7 -0.33 -6.27 -0.33 1.1e-9 Monocyte percentage of white cells; CRC cis rs561341 1.000 rs8064843 chr17:30245744 A/G cg12193833 chr17:30244370 NA -0.57 -8.01 -0.4 1.94e-14 Hip circumference adjusted for BMI; CRC cis rs6502050 0.799 rs4789673 chr17:80123218 T/C cg19223190 chr17:80058835 NA 0.39 6.23 0.32 1.43e-9 Life satisfaction; CRC cis rs4319547 0.661 rs7398014 chr12:122943980 T/C cg05707623 chr12:122985044 ZCCHC8 -0.8 -9.95 -0.48 1.47e-20 Body mass index; CRC cis rs10751667 0.643 rs6597969 chr11:928843 C/T cg06064525 chr11:970664 AP2A2 -0.33 -6.65 -0.34 1.25e-10 Alzheimer's disease (late onset); CRC trans rs875971 0.545 rs13311962 chr7:66068129 C/T cg02869306 chr7:64672164 INTS4L1 0.42 6.04 0.32 4.26e-9 Aortic root size; CRC trans rs2303319 0.504 rs35304298 chr2:162617185 G/T cg03774468 chr3:140950104 ACPL2 -0.65 -6.07 -0.32 3.46e-9 Cognitive function; CRC cis rs13108904 0.935 rs13148614 chr4:1248357 G/C cg02018176 chr4:1364513 KIAA1530 0.4 6.62 0.34 1.46e-10 Obesity-related traits; CRC cis rs9303280 0.806 rs4795400 chr17:38067020 C/T cg00129232 chr17:37814104 STARD3 -0.45 -6.97 -0.36 1.77e-11 Self-reported allergy; CRC cis rs7223966 1.000 rs3817181 chr17:61776538 G/C cg05941027 chr17:61774174 LIMD2 0.36 6.22 0.32 1.53e-9 Hip circumference adjusted for BMI;Body mass index; CRC cis rs6570726 0.791 rs9373464 chr6:145907167 T/C cg13319975 chr6:146136371 FBXO30 -0.41 -6.09 -0.32 3.1e-9 Lobe attachment (rater-scored or self-reported); CRC trans rs10435719 0.647 rs10092605 chr8:11787395 T/G cg06636001 chr8:8085503 FLJ10661 0.47 7.08 0.36 8.95e-12 C-reactive protein levels or triglyceride levels (pleiotropy); CRC cis rs11711311 1.000 rs62268169 chr3:113493860 G/A cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.51 -6.99 -0.36 1.57e-11 IgG glycosylation; CRC trans rs6600671 1.000 rs4844607 chr1:121184059 C/T cg09829573 chr1:144692074 NBPF9 0.4 6.11 0.32 2.75e-9 Hip geometry; CRC cis rs2839186 0.814 rs2839167 chr21:47661587 A/G cg05896524 chr21:47604654 C21orf56 0.49 7.51 0.38 5.47e-13 Testicular germ cell tumor; CRC cis rs7296418 0.961 rs1727307 chr12:123575742 A/G cg00376283 chr12:123451042 ABCB9 0.65 9.81 0.48 4.38e-20 Platelet count; CRC cis rs10883723 0.810 rs7074343 chr10:104283165 G/A cg11453585 chr10:104263688 ACTR1A;SUFU 0.91 17.47 0.69 8.43e-49 Allergic disease (asthma, hay fever or eczema); CRC cis rs2842992 0.692 rs9347342 chr6:160193129 T/C cg11366901 chr6:160182831 ACAT2 0.74 11.41 0.53 1.27e-25 Age-related macular degeneration (geographic atrophy); CRC cis rs12928939 0.911 rs12917983 chr16:71835243 A/C cg08717414 chr16:71523259 ZNF19 -0.51 -6.43 -0.33 4.45e-10 Post bronchodilator FEV1; CRC cis rs13108904 0.901 rs12642410 chr4:1308409 A/G cg00684032 chr4:1343700 KIAA1530 0.46 6.59 0.34 1.78e-10 Obesity-related traits; CRC cis rs9291683 0.588 rs35438220 chr4:9999398 C/T cg11266682 chr4:10021025 SLC2A9 0.54 11.45 0.53 8.7e-26 Bone mineral density; CRC cis rs748404 0.516 rs523156 chr15:43811843 C/G cg02155558 chr15:43621948 ADAL;LCMT2 -0.43 -6.06 -0.32 3.83e-9 Lung cancer; CRC cis rs6011002 0.683 rs6089966 chr20:62361250 A/G cg01176363 chr20:62369445 LIME1 -0.72 -5.67 -0.3 3.14e-8 Dental caries; CRC cis rs1448094 0.967 rs10863115 chr12:86332586 T/C cg18827107 chr12:86230957 RASSF9 -0.37 -6.04 -0.32 4.16e-9 Major depressive disorder; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg03398303 chr18:12702742 PSMG2;CEP76 0.45 6.22 0.32 1.48e-9 Response to antipsychotic treatment; CRC trans rs4650994 0.544 rs2811314 chr1:178619183 C/T cg05059571 chr16:84539110 KIAA1609 0.63 8.94 0.44 2.79e-17 HDL cholesterol levels;HDL cholesterol; CRC cis rs7666738 0.830 rs62318471 chr4:98925848 G/A cg17366294 chr4:99064904 C4orf37 0.43 7.32 0.37 1.95e-12 Colonoscopy-negative controls vs population controls; CRC cis rs1692580 0.846 rs377599 chr1:2164699 C/T cg21194808 chr1:2205498 SKI 0.44 6.66 0.34 1.14e-10 Coronary artery disease; CRC cis rs4076764 0.958 rs6688997 chr1:163411562 G/A cg24596788 chr1:163392923 NA -0.69 -11.07 -0.52 2.02e-24 Motion sickness; CRC cis rs2479724 0.598 rs4415146 chr6:41941980 G/T cg17623882 chr6:41773611 USP49 0.45 7.31 0.37 2.04e-12 Menarche (age at onset); CRC cis rs7647973 0.925 rs11130183 chr3:49228946 A/G cg20833759 chr3:49053208 WDR6;DALRD3 0.55 8.44 0.42 1.01e-15 Menarche (age at onset); CRC cis rs10540 1.000 rs35255804 chr11:492617 G/A cg15790184 chr11:494944 RNH1 0.6 6.18 0.32 1.85e-9 Body mass index; CRC cis rs1707322 0.656 rs9429172 chr1:46092476 C/G cg06784218 chr1:46089804 CCDC17 -0.66 -12.04 -0.55 6.41e-28 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg19778287 chr11:82905545 ANKRD42 0.46 6.56 0.34 2.11e-10 Response to antipsychotic treatment; CRC cis rs6142102 0.961 rs2235596 chr20:32684309 A/G cg08999081 chr20:33150536 PIGU -0.37 -5.84 -0.31 1.26e-8 Skin pigmentation; CRC cis rs4481887 0.676 rs7520659 chr1:248527586 C/A cg00666640 chr1:248458726 OR2T12 0.35 6.53 0.34 2.54e-10 Common traits (Other); CRC cis rs28386778 0.897 rs2137144 chr17:61805607 G/A cg23090583 chr17:61904693 PSMC5;FTSJ3 1.01 19.05 0.72 4.76e-55 Prudent dietary pattern; CRC cis rs7584330 0.554 rs6740834 chr2:238423442 T/C cg08992911 chr2:238395768 MLPH 0.46 5.73 0.3 2.26e-8 Prostate cancer; CRC cis rs12928939 0.911 rs12917983 chr16:71835243 A/C cg03805757 chr16:71968109 PKD1L3 -0.46 -5.96 -0.31 6.62e-9 Post bronchodilator FEV1; CRC cis rs12760731 0.920 rs12747346 chr1:178488809 T/C cg00404053 chr1:178313656 RASAL2 0.59 6.91 0.36 2.47e-11 Obesity-related traits; CRC cis rs10256972 0.616 rs6463001 chr7:1108272 A/C cg18402987 chr7:1209562 NA 0.43 6.62 0.34 1.45e-10 Longevity;Endometriosis; CRC cis rs524281 0.731 rs1125078 chr11:65809875 C/A cg16950941 chr11:66035639 RAB1B 0.51 6.05 0.32 3.98e-9 Electroencephalogram traits; CRC cis rs2289681 0.525 rs12451394 chr17:42979592 G/A cg15193461 chr17:42977049 CCDC103;EFTUD2 -0.53 -6.09 -0.32 3.23e-9 Cognitive function; CRC cis rs4713118 0.662 rs9468274 chr6:28026077 G/T cg23161317 chr6:28129485 ZNF389 0.44 5.71 0.3 2.49e-8 Parkinson's disease; CRC cis rs427941 0.703 rs10953358 chr7:101738226 T/C cg06246474 chr7:101738831 CUX1 -0.46 -7.16 -0.37 5.46e-12 Plasma omega-3 polyunsaturated fatty acid level (eicosapentaenoic acid); CRC cis rs2739330 0.796 rs2154594 chr22:24254055 A/G cg11905131 chr22:24372483 LOC391322 0.71 11.48 0.53 7.27e-26 Liver enzyme levels (gamma-glutamyl transferase); CRC trans rs1814175 0.676 rs1721999 chr11:49917372 A/G cg03929089 chr4:120376271 NA -0.91 -16.07 -0.66 2.65e-43 Height; CRC trans rs7615952 0.866 rs1976459 chr3:125647486 A/T cg02560186 chr11:3602584 NA -0.47 -6.31 -0.33 9.08e-10 Blood pressure (smoking interaction); CRC cis rs7618915 0.547 rs3755806 chr3:52643685 C/T cg10802521 chr3:52805072 NEK4 0.57 8.84 0.44 5.93e-17 Bipolar disorder; CRC cis rs11083475 0.714 rs1471432 chr19:39260282 G/A cg26703956 chr19:39260304 NA -0.38 -6.24 -0.33 1.37e-9 Heart rate; CRC cis rs4481887 0.861 rs1339989 chr1:248511624 C/G cg13385794 chr1:248469461 NA 0.34 6.2 0.32 1.71e-9 Common traits (Other); CRC cis rs2635047 0.638 rs9956809 chr18:44655843 A/G cg19077165 chr18:44547161 KATNAL2 -0.43 -6.66 -0.34 1.17e-10 Educational attainment; CRC cis rs853679 0.517 rs2273564 chr6:28057594 A/T cg18032046 chr6:28092343 ZSCAN16 -0.5 -5.84 -0.31 1.26e-8 Depression; CRC cis rs16852403 0.548 rs10798600 chr1:178180719 C/T cg00404053 chr1:178313656 RASAL2 0.49 6.38 0.33 5.97e-10 Childhood ear infection; CRC cis rs617791 0.569 rs11227370 chr11:65747693 C/T cg09783858 chr11:65769428 EIF1AD;BANF1 0.48 7.23 0.37 3.38e-12 Breast cancer; CRC cis rs561341 0.883 rs4795661 chr17:30201774 T/A cg19193384 chr17:30244184 NA 0.46 5.7 0.3 2.62e-8 Hip circumference adjusted for BMI; CRC cis rs651907 0.557 rs3806654 chr3:101396529 G/C cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.68 9.53 0.47 3.56e-19 Colorectal cancer; CRC cis rs3785574 0.962 rs62077509 chr17:61848973 A/G cg06601766 chr17:61851465 DDX42;CCDC47 0.6 8.54 0.43 5.06e-16 Height; CRC cis rs4604732 0.631 rs34924545 chr1:247626892 G/T cg02104434 chr1:247694406 LOC148824;OR2C3 0.6 8.82 0.44 6.97e-17 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CRC cis rs364477 1.000 rs364477 chr9:955794 A/G cg13952963 chr9:998547 NA -0.48 -6.27 -0.33 1.14e-9 Major depressive disorder; CRC cis rs2380220 0.606 rs7754906 chr6:95992429 C/T cg04719120 chr6:96025338 MANEA 0.52 6.39 0.33 5.56e-10 Behavioural disinhibition (generation interaction); CRC cis rs6831352 0.918 rs29001231 chr4:100046680 T/C cg13256891 chr4:100009986 ADH5 -0.66 -8.89 -0.44 4.04e-17 Alcohol dependence; CRC cis rs4713118 0.662 rs149900 chr6:28014597 C/T cg03623178 chr6:28175578 NA 0.87 12.13 0.56 2.98e-28 Parkinson's disease; CRC cis rs2580764 0.598 rs2580772 chr2:55218805 G/T cg09592903 chr2:55203963 RTN4 0.73 11.76 0.54 6.58e-27 Mean platelet volume; CRC cis rs73200209 0.744 rs17426239 chr12:116438287 A/G cg01776926 chr12:116560359 MED13L 0.57 6.44 0.33 4.33e-10 Total body bone mineral density; CRC cis rs965469 1.000 rs6133036 chr20:3349682 A/G cg25506879 chr20:3388711 C20orf194 -0.4 -5.77 -0.3 1.81e-8 IFN-related cytopenia; CRC cis rs924607 0.966 rs1709554 chr5:637443 A/G cg24163568 chr5:669837 TPPP 0.43 6.83 0.35 4.09e-11 Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia; CRC cis rs1223397 0.651 rs2496146 chr6:13312474 A/G cg20827128 chr6:13274284 PHACTR1 0.38 5.81 0.3 1.5e-8 Blood pressure; CRC cis rs7333181 1.000 rs36045739 chr13:112232686 G/A cg27543320 chr13:112200689 NA 0.44 5.91 0.31 8.76e-9 Menopause (age at onset); CRC cis rs1707322 0.752 rs3811436 chr1:46125880 T/C cg03146154 chr1:46216737 IPP 0.66 9.65 0.47 1.44e-19 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs780096 0.565 rs8179252 chr2:27746832 A/C cg21248554 chr2:27665150 KRTCAP3 -0.3 -6.88 -0.35 3.02e-11 Total body bone mineral density; CRC cis rs6088590 1.000 rs6120705 chr20:33313740 T/C cg24642439 chr20:33292090 TP53INP2 0.59 10.76 0.51 2.55e-23 Coronary artery disease; CRC cis rs1153858 1.000 rs7164602 chr15:45671325 A/G cg14582100 chr15:45693742 SPATA5L1 0.28 5.72 0.3 2.41e-8 Homoarginine levels; CRC cis rs1832871 0.683 rs6908487 chr6:158713047 G/T cg07165851 chr6:158734300 TULP4 0.62 7.75 0.39 1.18e-13 Height; CRC cis rs12997796 0.556 rs34933869 chr2:86922397 T/C cg25203885 chr2:87302643 LOC285074 -0.58 -5.93 -0.31 7.58e-9 Schizophrenia; CRC cis rs765787 0.530 rs2433227 chr15:45517119 A/T cg24006582 chr15:45444508 DUOX1 -0.57 -8.75 -0.43 1.15e-16 Uric acid levels; CRC cis rs860295 0.676 rs10908466 chr1:155429725 A/C cg02153340 chr1:155202674 NA -0.58 -6.82 -0.35 4.33e-11 Body mass index; CRC trans rs9388451 0.807 rs1268065 chr6:126042783 G/A cg05039488 chr6:79577232 IRAK1BP1 0.55 8.15 0.41 7.55e-15 Brugada syndrome; CRC cis rs10504229 0.775 rs72650876 chr8:58161638 G/A cg24829409 chr8:58192753 C8orf71 -0.6 -8.04 -0.41 1.67e-14 Developmental language disorder (linguistic errors); CRC cis rs11212617 0.901 rs11212538 chr11:108045956 C/T cg12106634 chr11:108092400 ATM;NPAT 0.4 5.89 0.31 9.44e-9 Response to metformin in type 2 diabetes (glycemic); CRC cis rs10504229 0.683 rs67048677 chr8:58140023 C/G cg02290350 chr8:58132656 NA -0.58 -8.16 -0.41 7.29e-15 Developmental language disorder (linguistic errors); CRC cis rs4880487 0.853 rs1876898 chr10:1249986 C/T cg03183215 chr10:1252341 ADARB2 -0.27 -5.81 -0.31 1.47e-8 Migraine; CRC cis rs10782582 0.609 rs1770889 chr1:76401166 A/G cg10523679 chr1:76189770 ACADM -0.39 -5.65 -0.3 3.43e-8 Daytime sleep phenotypes; CRC cis rs11958404 0.932 rs72816552 chr5:157422376 G/A cg05962755 chr5:157440814 NA 0.84 11.22 0.53 5.68e-25 IgG glycosylation; CRC cis rs7605827 0.930 rs6723148 chr2:15592019 G/T cg19274914 chr2:15703543 NA 0.38 5.77 0.3 1.84e-8 Educational attainment (years of education); CRC cis rs6502050 0.799 rs6502088 chr17:80169484 C/T cg19223190 chr17:80058835 NA 0.41 6.6 0.34 1.67e-10 Life satisfaction; CRC cis rs4713118 0.513 rs149945 chr6:28002853 T/C cg23161317 chr6:28129485 ZNF389 0.44 6.41 0.33 5.12e-10 Parkinson's disease; CRC cis rs7113874 0.589 rs10840058 chr11:8498399 G/T cg20771178 chr11:8615675 STK33 0.34 5.67 0.3 3.07e-8 Body mass index in physically active individuals;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs11864453 0.713 rs9925763 chr16:72142595 C/A cg01557791 chr16:72042693 DHODH -0.44 -6.15 -0.32 2.23e-9 Fibrinogen levels; CRC cis rs12497850 0.931 rs6446253 chr3:48911443 C/T cg07636037 chr3:49044803 WDR6 1.02 18.52 0.71 5.84e-53 Parkinson's disease; CRC cis rs736408 0.812 rs1075653 chr3:52825528 T/C cg15147215 chr3:52552868 STAB1 -0.57 -9.09 -0.45 9.6e-18 Bipolar disorder; CRC cis rs932541 1.000 rs6034490 chr20:16457021 G/A cg17003395 chr20:16555519 KIF16B 0.41 5.63 0.3 3.82e-8 Intelligence; CRC trans rs2055729 0.710 rs6981023 chr8:9746585 C/T cg06636001 chr8:8085503 FLJ10661 -0.55 -7.3 -0.37 2.25e-12 Multiple myeloma (hyperdiploidy); CRC trans rs1814175 0.817 rs6486046 chr11:49997017 T/C cg21153622 chr11:89784906 NA -0.38 -6.01 -0.31 4.86e-9 Height; CRC cis rs11948739 0.539 rs1119863 chr5:130282399 T/G cg08523029 chr5:130500466 HINT1 0.46 5.62 0.3 4.02e-8 Pediatric bone mineral content (hip); CRC cis rs5751901 1.000 rs5751901 chr22:24992266 C/T cg08808123 chr22:24999002 GGT1 0.4 5.85 0.31 1.19e-8 Protein quantitative trait loci; CRC cis rs6952808 1.000 rs4256490 chr7:1890764 G/A cg22963979 chr7:1858916 MAD1L1 -0.66 -10.09 -0.49 4.87e-21 Bipolar disorder and schizophrenia; CRC cis rs1256061 0.624 rs1152586 chr14:64690784 T/C cg23250157 chr14:64679961 SYNE2 0.48 7.39 0.38 1.24e-12 Hemoglobin concentration;Red blood cell count;Hematocrit; CRC trans rs10504229 1.000 rs1961778 chr8:58168756 G/A cg04077850 chr5:125800366 GRAMD3 0.36 6.15 0.32 2.22e-9 Developmental language disorder (linguistic errors); CRC cis rs6540559 0.673 rs17015361 chr1:210018901 C/G cg22029157 chr1:209979665 IRF6 0.62 7.4 0.38 1.18e-12 Cleft lip with or without cleft palate; CRC cis rs6459804 1.000 rs6459805 chr7:157510294 T/C cg05585630 chr7:157510462 PTPRN2 -0.43 -6.86 -0.35 3.47e-11 Bipolar disorder and schizophrenia; CRC cis rs853679 1.000 rs1778511 chr6:28229411 G/A cg15786705 chr6:28176104 NA -0.58 -6.11 -0.32 2.89e-9 Depression; CRC cis rs12477438 0.572 rs10170063 chr2:99655639 A/C cg14399236 chr2:99771627 LIPT1;TSGA10 -0.6 -8.19 -0.41 6.03e-15 Chronic sinus infection; CRC cis rs651907 0.557 rs34624546 chr3:101374226 T/G cg11279151 chr3:101281821 RG9MTD1 -0.57 -7.76 -0.39 1.05e-13 Colorectal cancer; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg05775451 chr1:228353712 C1orf69 0.39 6.26 0.33 1.22e-9 Liver disease severity in Alagille syndrome; CRC cis rs1348850 0.567 rs12994392 chr2:178536640 A/G cg02961200 chr2:178257176 LOC100130691;AGPS 0.59 8.38 0.42 1.6e-15 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs4665809 0.590 rs962217 chr2:26438276 T/C cg27170947 chr2:26402098 FAM59B -0.61 -7.93 -0.4 3.51e-14 Gut microbiome composition (summer); CRC cis rs10992471 0.630 rs10992322 chr9:95159196 A/G cg13798575 chr9:95087839 CENPP;NOL8 -0.4 -5.96 -0.31 6.41e-9 Visceral adipose tissue/subcutaneous adipose tissue ratio; CRC cis rs597539 0.652 rs660614 chr11:68659488 G/A cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.9 15.68 0.65 8.67e-42 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs11214589 0.651 rs11214595 chr11:113259658 G/T cg14159747 chr11:113255604 NA 0.62 12.62 0.57 4.66e-30 Neuroticism; CRC cis rs11098499 0.554 rs2175381 chr4:120265967 T/C cg09307838 chr4:120376055 NA 0.62 9.69 0.47 1.07e-19 Corneal astigmatism; CRC cis rs11148252 0.811 rs9535895 chr13:52765847 G/A cg00495681 chr13:53174319 NA 0.58 8.87 0.44 4.78e-17 Lewy body disease; CRC cis rs10991814 0.920 rs76218486 chr9:94027677 T/A cg14446406 chr9:93919335 NA 0.58 6.41 0.33 5.03e-10 Neutrophil percentage of granulocytes; CRC cis rs7617480 0.519 rs6790914 chr3:49206318 G/C cg07636037 chr3:49044803 WDR6 0.77 11.25 0.53 4.8e-25 Subjective well-being (multi-trait analysis);Menarche (age at onset); CRC cis rs28386778 0.897 rs7212196 chr17:61834981 T/C cg06873352 chr17:61820015 STRADA 0.78 14.48 0.62 4.13e-37 Prudent dietary pattern; CRC cis rs9467711 0.606 rs71557334 chr6:26365913 G/T cg16898833 chr6:26189333 HIST1H4D 0.76 6.58 0.34 1.88e-10 Autism spectrum disorder or schizophrenia; CRC trans rs9650657 0.707 rs11250076 chr8:10647823 A/G cg06636001 chr8:8085503 FLJ10661 -0.46 -6.81 -0.35 4.72e-11 Neuroticism; CRC cis rs929354 0.772 rs6957939 chr7:156978485 T/C cg17757837 chr7:157058334 UBE3C 0.74 12.6 0.57 5.83e-30 Body mass index; CRC cis rs7212590 0.618 rs59767604 chr17:58041339 C/G cg10252138 chr17:58120427 NA -0.58 -6.28 -0.33 1.1e-9 Granulocyte percentage of myeloid white cells;Monocyte count;Monocyte percentage of white cells; CRC cis rs4594175 0.707 rs4901102 chr14:51746605 C/T cg23942311 chr14:51606299 NA -0.46 -6.98 -0.36 1.63e-11 Cancer; CRC cis rs7959452 0.535 rs1350166 chr12:69636314 G/T cg20891283 chr12:69753455 YEATS4 0.79 13.04 0.58 1.27e-31 Blood protein levels; CRC trans rs7618501 0.699 rs2681781 chr3:49898273 A/G cg21665057 chr3:196295764 WDR53;FBXO45 0.67 10.57 0.5 1.14e-22 Intelligence (multi-trait analysis); CRC cis rs10504073 0.584 rs56078938 chr8:49940342 A/C cg00325661 chr8:49890786 NA 0.61 11.02 0.52 3.06e-24 Blood metabolite ratios; CRC trans rs61931739 0.500 rs11053271 chr12:34545407 C/A cg26384229 chr12:38710491 ALG10B 0.68 8.8 0.44 7.69e-17 Morning vs. evening chronotype; CRC cis rs801193 1.000 rs7782320 chr7:66177098 C/T cg25985355 chr7:65971099 NA -0.32 -5.64 -0.3 3.73e-8 Aortic root size; CRC cis rs6810498 0.774 rs4692328 chr4:26054619 C/T cg12925881 chr4:26050407 NA 0.34 5.7 0.3 2.68e-8 Alcohol dependence; CRC cis rs12580194 0.556 rs58780687 chr12:55736498 A/C cg23425280 chr12:56401806 NA 0.48 5.91 0.31 8.48e-9 Cancer; CRC cis rs7666738 0.830 rs28802909 chr4:99039410 G/A cg17366294 chr4:99064904 C4orf37 0.44 7.5 0.38 6.02e-13 Colonoscopy-negative controls vs population controls; CRC cis rs7666738 0.830 rs1593570 chr4:99017058 T/C cg17366294 chr4:99064904 C4orf37 0.43 7.28 0.37 2.52e-12 Colonoscopy-negative controls vs population controls; CRC cis rs12476592 0.602 rs1348805 chr2:63895673 A/G cg10828910 chr2:63850056 LOC388955 0.51 6.44 0.33 4.22e-10 Childhood ear infection; CRC cis rs6499255 0.951 rs11641233 chr16:69734563 C/T cg15192750 chr16:69999425 NA 0.53 7.31 0.37 2e-12 IgE levels; CRC cis rs3540 0.533 rs4932342 chr15:90982923 C/T cg22089800 chr15:90895588 ZNF774 0.57 9.49 0.46 4.75e-19 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; CRC cis rs1552244 1.000 rs6768102 chr3:10149380 A/G cg16606324 chr3:10149918 C3orf24 0.69 9.18 0.45 4.79e-18 Alzheimer's disease; CRC cis rs7666738 0.830 rs60391193 chr4:98933912 T/G cg05340658 chr4:99064831 C4orf37 0.6 9.35 0.46 1.41e-18 Colonoscopy-negative controls vs population controls; CRC cis rs4808199 0.948 rs757000 chr19:19448301 A/G cg03709012 chr19:19516395 GATAD2A 0.96 11.1 0.52 1.55e-24 Nonalcoholic fatty liver disease; CRC cis rs875971 0.862 rs10256544 chr7:65675128 A/G cg00343986 chr7:65444356 GUSB 0.42 6.05 0.32 3.98e-9 Aortic root size; CRC cis rs9427116 0.502 rs12125166 chr1:154582129 A/G cg24304309 chr1:154577895 ADAR -0.34 -5.65 -0.3 3.48e-8 Blood protein levels; CRC cis rs6500395 0.775 rs4471681 chr16:48665946 C/T cg04672837 chr16:48644449 N4BP1 0.44 6.53 0.34 2.53e-10 Response to tocilizumab in rheumatoid arthritis; CRC cis rs853679 1.000 rs853678 chr6:28297313 T/A cg06470822 chr6:28175283 NA 0.59 6.14 0.32 2.39e-9 Depression; CRC cis rs477692 0.507 rs7080570 chr10:131455328 C/T cg05714579 chr10:131428358 MGMT -0.41 -5.76 -0.3 1.96e-8 Response to temozolomide; CRC cis rs6724607 1.000 rs7598979 chr2:191453375 A/G cg21644426 chr2:191273491 MFSD6 0.45 6.07 0.32 3.56e-9 Pulse pressure; CRC cis rs7932354 0.528 rs6485739 chr11:47145072 G/A cg19486271 chr11:47235900 DDB2 -0.49 -7.53 -0.38 4.81e-13 Bone mineral density (hip);Bone mineral density; CRC cis rs2286885 0.965 rs741024 chr9:129251821 A/G cg15282417 chr9:129245246 FAM125B -0.45 -8.48 -0.42 7.7e-16 Intraocular pressure; CRC cis rs8060686 0.920 rs3809630 chr16:67879400 G/A cg08314208 chr16:67682810 RLTPR -0.64 -7.34 -0.38 1.63e-12 HDL cholesterol;Metabolic syndrome; CRC cis rs2739330 0.760 rs1007888 chr22:24241101 C/T cg18538332 chr22:24372958 LOC391322 -0.68 -10.65 -0.51 5.9e-23 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs3750082 0.889 rs970673 chr7:32927727 A/G cg05721444 chr7:32995514 FKBP9 0.5 7.76 0.39 1.12e-13 Glomerular filtration rate (creatinine); CRC cis rs4713118 0.615 rs9348772 chr6:27656090 G/T cg03623178 chr6:28175578 NA 0.51 7.16 0.37 5.35e-12 Parkinson's disease; CRC cis rs2019137 0.560 rs10175462 chr2:113988492 G/A cg21482265 chr2:113992762 PAX8;LOC440839;LOC654433 0.59 9.16 0.45 5.88e-18 Lymphocyte counts; CRC cis rs13256369 1.000 rs9329166 chr8:8576655 C/T cg17143192 chr8:8559678 CLDN23 0.48 5.76 0.3 1.89e-8 Obesity-related traits; CRC cis rs62229266 0.771 rs11701590 chr21:37384730 A/C cg08632701 chr21:37451849 NA -0.43 -6.71 -0.35 8.49e-11 Mitral valve prolapse; CRC cis rs4588572 0.644 rs6882191 chr5:77743098 G/A cg11446398 chr5:77624930 NA 0.42 6.01 0.31 5.01e-9 Triglycerides; CRC cis rs13256369 0.901 rs12679831 chr8:8566411 T/G cg00074818 chr8:8560427 CLDN23 0.4 6.99 0.36 1.58e-11 Obesity-related traits; CRC cis rs55882075 0.723 rs56227602 chr5:179179472 A/G cg14593053 chr5:179126677 CANX 0.52 8.38 0.42 1.55e-15 Monocyte percentage of white cells; CRC cis rs10751667 0.666 rs10902248 chr11:957742 A/G cg01483505 chr11:975446 AP2A2 0.45 7.58 0.39 3.59e-13 Alzheimer's disease (late onset); CRC cis rs7208859 0.673 rs73277984 chr17:29196133 T/C cg13385521 chr17:29058706 SUZ12P 0.65 7.71 0.39 1.51e-13 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs11971779 0.793 rs4732366 chr7:139027845 G/C cg07862535 chr7:139043722 LUC7L2 0.8 10.45 0.5 2.9e-22 Diisocyanate-induced asthma; CRC cis rs2014572 1.000 rs3746231 chr19:57760057 G/A cg24459738 chr19:57751996 ZNF805 -0.57 -8.99 -0.44 1.93e-17 Hyperactive-impulsive symptoms; CRC cis rs12024301 0.557 rs7517163 chr1:183594872 C/A cg11505048 chr1:183622726 RGL1;APOBEC4 0.76 6.93 0.36 2.16e-11 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs10256972 0.681 rs6979076 chr7:1116247 C/T cg03923535 chr7:1197113 ZFAND2A -0.6 -8.61 -0.43 3.15e-16 Longevity;Endometriosis; CRC cis rs6860806 0.507 rs272854 chr5:131688017 C/T cg20512303 chr5:131592959 PDLIM4 0.38 6.51 0.34 2.77e-10 Breast cancer; CRC cis rs9486719 0.947 rs2499801 chr6:96854594 G/A cg06623918 chr6:96969491 KIAA0776 0.81 9.24 0.45 3.05e-18 Migraine;Coronary artery disease; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg00091162 chr1:167906284 BRP44;DCAF6 0.42 6.12 0.32 2.61e-9 Anxiety disorder; CRC cis rs769267 0.930 rs892021 chr19:19613480 T/C cg03709012 chr19:19516395 GATAD2A 0.72 11.21 0.53 6.56e-25 Tonsillectomy; CRC cis rs965469 1.000 rs2236087 chr20:3255905 C/T cg25506879 chr20:3388711 C20orf194 -0.39 -5.63 -0.3 3.88e-8 IFN-related cytopenia; CRC cis rs1348850 0.914 rs12469386 chr2:178358281 A/G cg02961200 chr2:178257176 LOC100130691;AGPS -0.55 -7.94 -0.4 3.19e-14 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs10924970 0.687 rs10802286 chr1:235349239 A/G cg09010748 chr1:235293032 TOMM20 0.4 5.63 0.3 3.83e-8 Asthma; CRC cis rs1712517 0.836 rs7093039 chr10:105149547 A/G cg05636881 chr10:105038444 INA 0.49 8.41 0.42 1.26e-15 Migraine; CRC cis rs2303759 0.507 rs1465696 chr19:49837439 G/A cg22307029 chr19:49891270 CCDC155 0.64 6.08 0.32 3.32e-9 Multiple sclerosis; CRC cis rs10979 0.928 rs6924967 chr6:143906235 C/T cg25407410 chr6:143891975 LOC285740 -0.81 -12.95 -0.58 2.76e-31 Hypospadias; CRC cis rs35306767 0.951 rs61833265 chr10:990143 C/T cg26597838 chr10:835615 NA 1.04 12.45 0.57 1.95e-29 Eosinophil percentage of granulocytes; CRC cis rs514406 0.929 rs12410420 chr1:53323754 T/C cg27535305 chr1:53392650 SCP2 -0.37 -6.77 -0.35 5.97e-11 Monocyte count; CRC cis rs7119 0.717 rs11635567 chr15:77819515 A/G cg10437265 chr15:77819839 NA 0.67 12.38 0.56 3.61e-29 Type 2 diabetes; CRC cis rs6062302 0.522 rs6090475 chr20:62245397 C/A cg16989086 chr20:62203971 PRIC285 0.5 6.47 0.34 3.65e-10 Glioblastoma; CRC cis rs11608355 0.545 rs2302708 chr12:109893726 A/C cg05360138 chr12:110035743 NA 0.77 8.7 0.43 1.65e-16 Neuroticism; CRC cis rs71391092 1 rs71391092 chr16:74567075 C/G cg01733217 chr16:74700730 RFWD3 -0.67 -6.41 -0.33 5.19e-10 Schizophrenia; CRC cis rs6500596 0.570 rs8055628 chr16:4447477 G/A cg14951292 chr16:4525986 HMOX2;NMRAL1 0.62 7.27 0.37 2.59e-12 Schizophrenia; CRC cis rs9462027 0.628 rs9469909 chr6:34813077 C/G cg07306190 chr6:34760872 UHRF1BP1 -0.34 -6.02 -0.32 4.63e-9 Systemic lupus erythematosus; CRC cis rs7618915 0.524 rs35249778 chr3:52661640 G/C cg05573699 chr3:52720067 GNL3;PBRM1 -0.46 -6.62 -0.34 1.42e-10 Bipolar disorder; CRC cis rs9649213 0.593 rs34534766 chr7:97920871 G/C cg00277769 chr7:97922759 BAIAP2L1 -0.61 -10.73 -0.51 3.09e-23 Prostate cancer (SNP x SNP interaction); CRC cis rs10927875 0.619 rs12121764 chr1:16138059 A/T cg21385522 chr1:16154831 NA -0.73 -11.75 -0.54 7.43e-27 Dilated cardiomyopathy; CRC cis rs6831352 0.760 rs1311616 chr4:100012303 T/G cg12011299 chr4:100065546 ADH4 0.49 9.16 0.45 5.61e-18 Alcohol dependence; CRC cis rs9326248 0.520 rs236919 chr11:117095361 A/G cg01368799 chr11:117014884 PAFAH1B2 0.54 8.75 0.43 1.14e-16 Blood protein levels; CRC cis rs8060686 0.621 rs35432211 chr16:68095449 T/C cg08314208 chr16:67682810 RLTPR -0.64 -6.85 -0.35 3.57e-11 HDL cholesterol;Metabolic syndrome; CRC cis rs1816752 0.870 rs3825449 chr13:25014441 A/C cg02811702 chr13:24901961 NA 0.47 6.55 0.34 2.16e-10 Obesity-related traits; CRC cis rs7666738 0.791 rs17549003 chr4:98969132 A/C cg05340658 chr4:99064831 C4orf37 0.6 9.45 0.46 6.71e-19 Colonoscopy-negative controls vs population controls; CRC cis rs2840044 1.000 rs225262 chr17:33959697 A/G cg05299278 chr17:33885742 SLFN14 0.39 5.86 0.31 1.14e-8 Response to radiotherapy in cancer (late toxicity); CRC cis rs6810498 0.735 rs871384 chr4:26052506 A/T cg12925881 chr4:26050407 NA -0.42 -7.97 -0.4 2.59e-14 Alcohol dependence; CRC cis rs7680126 0.596 rs4637402 chr4:10045430 C/T cg11266682 chr4:10021025 SLC2A9 0.45 7.23 0.37 3.4e-12 Urate levels in lean individuals;Urate levels in overweight individuals;Urate levels in obese individuals; CRC cis rs7129556 0.954 rs11823651 chr11:77253879 G/A cg12586386 chr11:77299805 AQP11 0.43 6.02 0.31 4.79e-9 Weight loss (gastric bypass surgery); CRC trans rs61931739 0.500 rs11052966 chr12:34019826 C/T cg26384229 chr12:38710491 ALG10B 0.5 6.93 0.36 2.27e-11 Morning vs. evening chronotype; CRC cis rs72781680 0.716 rs2712065 chr2:23973603 C/T cg08917208 chr2:24149416 ATAD2B -0.53 -6.48 -0.34 3.33e-10 Lymphocyte counts; CRC cis rs7607369 0.536 rs6436090 chr2:219669002 A/G cg02176678 chr2:219576539 TTLL4 -0.39 -6.34 -0.33 7.69e-10 Red blood cell count;Amyotrophic lateral sclerosis; CRC cis rs73200209 0.912 rs59509739 chr12:116573496 A/G cg01776926 chr12:116560359 MED13L -0.48 -5.79 -0.3 1.62e-8 Total body bone mineral density; CRC cis rs13191362 1.000 rs35575481 chr6:163007746 T/A cg06582575 chr6:163149167 PACRG;PARK2 0.76 10.41 0.5 4.01e-22 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs4481887 0.927 rs4336885 chr1:248473168 A/C cg00666640 chr1:248458726 OR2T12 0.48 8.16 0.41 6.97e-15 Common traits (Other); CRC cis rs10751667 0.621 rs7394681 chr11:952111 C/T cg23136738 chr11:925521 AP2A2 -0.41 -7.01 -0.36 1.32e-11 Alzheimer's disease (late onset); CRC cis rs9039 1.000 rs1128001 chr16:9207003 T/C cg08831531 chr16:9218945 NA -0.58 -8.08 -0.41 1.24e-14 Menopause (age at onset); CRC cis rs6840360 0.582 rs59714108 chr4:152325939 G/A cg09659197 chr4:152720779 NA 0.3 5.66 0.3 3.28e-8 Intelligence (multi-trait analysis); CRC cis rs9837602 1.000 rs9864437 chr3:99764754 G/A cg07805332 chr3:99536008 MIR548G;C3orf26 -0.48 -6.33 -0.33 8.13e-10 Breast cancer; CRC cis rs6952808 0.689 rs1107591 chr7:2041638 G/A cg18279126 chr7:2041391 MAD1L1 0.4 5.93 0.31 7.82e-9 Bipolar disorder and schizophrenia; CRC cis rs9303401 0.921 rs34102441 chr17:56877414 A/G cg10487724 chr17:56770010 TEX14;RAD51C 0.56 8.2 0.41 5.52e-15 Cognitive test performance; CRC cis rs853679 0.517 rs3823180 chr6:28061744 G/A cg02683197 chr6:28174875 NA 0.82 10.03 0.48 7.9e-21 Depression; CRC cis rs9457247 0.508 rs9459874 chr6:167504127 A/G cg07513332 chr6:167530253 CCR6 -0.32 -5.79 -0.3 1.62e-8 Crohn's disease; CRC cis rs514406 0.607 rs11206000 chr1:53205923 A/C cg27535305 chr1:53392650 SCP2 0.34 6.36 0.33 6.7e-10 Monocyte count; CRC cis rs17065868 0.764 rs9533866 chr13:45037907 G/A cg10246903 chr13:45222710 NA 0.54 5.69 0.3 2.79e-8 Antineutrophil cytoplasmic antibody-associated vasculitis; CRC cis rs7666738 0.830 rs11940273 chr4:98979965 T/A cg05340658 chr4:99064831 C4orf37 0.59 9.22 0.45 3.6e-18 Colonoscopy-negative controls vs population controls; CRC cis rs1552244 0.872 rs7646073 chr3:10097405 G/A cg16606324 chr3:10149918 C3orf24 0.7 9.66 0.47 1.31e-19 Alzheimer's disease; CRC cis rs4523957 0.928 rs4790071 chr17:2173184 A/G cg16513277 chr17:2031491 SMG6 -0.56 -9.56 -0.47 2.97e-19 Autism spectrum disorder or schizophrenia;Schizophrenia; CRC cis rs6504950 0.800 rs8065361 chr17:53008853 A/T cg26251398 chr17:52985966 TOM1L1 0.37 5.69 0.3 2.8e-8 Breast cancer; CRC cis rs854572 0.870 rs757158 chr7:94955528 C/T cg01874867 chr7:94954059 PON1 -0.62 -9.83 -0.48 3.55e-20 Paraoxonase activity; CRC cis rs35306767 0.903 rs17159970 chr10:935601 T/C cg20503657 chr10:835505 NA 0.97 12.01 0.55 8.78e-28 Eosinophil percentage of granulocytes; CRC cis rs6860806 0.661 rs2136187 chr5:131577894 T/C cg04518342 chr5:131593106 PDLIM4 0.47 8.82 0.44 6.73e-17 Breast cancer; CRC cis rs9487051 0.676 rs9374077 chr6:109600194 C/T cg01475377 chr6:109611718 NA -0.37 -6.54 -0.34 2.41e-10 Reticulocyte fraction of red cells; CRC cis rs1150668 0.796 rs2247002 chr6:28397951 G/C cg15845792 chr6:28175446 NA 0.45 6.66 0.34 1.13e-10 Pubertal anthropometrics; CRC cis rs6499255 0.951 rs10500551 chr16:69666970 C/T cg15192750 chr16:69999425 NA 0.56 7.55 0.38 4.24e-13 IgE levels; CRC cis rs1005277 0.579 rs2474574 chr10:38387295 C/T cg25517755 chr10:38738941 LOC399744 -0.44 -6.41 -0.33 5.05e-10 Extrinsic epigenetic age acceleration; CRC cis rs9733 0.593 rs10888384 chr1:150574256 C/T cg15448220 chr1:150897856 SETDB1 -0.4 -5.87 -0.31 1.04e-8 Tonsillectomy; CRC cis rs6735179 0.837 rs6548058 chr2:1775108 T/A cg19300414 chr2:1746591 PXDN 0.37 5.78 0.3 1.75e-8 Response to antipsychotic treatment; CRC cis rs916888 0.773 rs199533 chr17:44828931 G/A cg01570182 chr17:44337453 NA 1.29 14.37 0.62 1.1e-36 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs79149102 0.579 rs74023935 chr15:75359184 T/C cg09165964 chr15:75287851 SCAMP5 -0.61 -5.91 -0.31 8.68e-9 Lung cancer; CRC cis rs7833986 1.000 rs34608229 chr8:57097017 T/C cg23139584 chr8:56987506 RPS20;SNORD54 0.62 7.54 0.38 4.61e-13 Height; CRC cis rs10504229 0.679 rs17801003 chr8:58050930 A/G cg08219700 chr8:58056026 NA 0.56 6.65 0.34 1.2e-10 Developmental language disorder (linguistic errors); CRC cis rs4268898 0.636 rs72787385 chr2:24585820 G/A cg06627628 chr2:24431161 ITSN2 -0.82 -11.16 -0.52 9.63e-25 Asthma; CRC cis rs9457247 0.967 rs430145 chr6:167410369 C/T cg23791538 chr6:167370224 RNASET2 -0.39 -6.08 -0.32 3.37e-9 Crohn's disease; CRC cis rs11758351 0.660 rs77337633 chr6:26233610 T/C cg01420254 chr6:26195488 NA 0.73 8.07 0.41 1.31e-14 Gout;Renal underexcretion gout; CRC cis rs4654899 0.897 rs10799668 chr1:21169385 T/C cg02927042 chr1:21476669 EIF4G3 0.41 6.64 0.34 1.3e-10 Superior frontal gyrus grey matter volume; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg04135372 chr2:99061383 INPP4A 0.41 6.37 0.33 6.35e-10 Liver disease severity in Alagille syndrome; CRC cis rs11764590 0.651 rs12673687 chr7:2081873 C/T cg23422044 chr7:1970798 MAD1L1 -0.42 -5.99 -0.31 5.48e-9 Neuroticism; CRC cis rs875971 0.660 rs28698552 chr7:66005018 A/G cg05627663 chr7:65219948 SNORA22;CCT6P1 0.43 6.46 0.34 3.8e-10 Aortic root size; CRC cis rs11628318 0.614 rs942022 chr14:103108842 C/T cg08075719 chr14:103021372 NA -0.66 -7.86 -0.4 5.47e-14 Platelet count; CRC cis rs17376456 0.877 rs7701011 chr5:93311456 G/A cg21475434 chr5:93447410 FAM172A 0.77 7.8 0.4 8.13e-14 Diabetic retinopathy; CRC cis rs7107174 1.000 rs10899495 chr11:78123293 C/T cg02023728 chr11:77925099 USP35 0.42 6.3 0.33 9.33e-10 Testicular germ cell tumor; CRC trans rs116095464 0.558 rs7736600 chr5:231337 A/C cg00938859 chr5:1591904 SDHAP3 0.72 7.88 0.4 4.89e-14 Breast cancer; CRC cis rs7215564 0.730 rs7214653 chr17:78581450 A/G cg09596252 chr17:78655493 RPTOR -0.63 -6.69 -0.35 9.83e-11 Myopia (pathological); CRC cis rs2718058 0.639 rs2718036 chr7:37775288 T/A cg24998770 chr7:37888106 TXNDC3 0.38 6.07 0.32 3.48e-9 Alzheimer's disease (late onset); CRC cis rs6598955 0.671 rs11247901 chr1:26612693 T/A cg04990556 chr1:26633338 UBXN11 0.55 5.86 0.31 1.15e-8 Obesity-related traits; CRC cis rs4819052 0.765 rs2838868 chr21:46714641 A/G cg11663144 chr21:46675770 NA 0.71 9.89 0.48 2.22e-20 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs7258465 0.965 rs10408290 chr19:18542701 C/T cg10790698 chr19:18539756 SSBP4 -0.47 -8.71 -0.43 1.53e-16 Breast cancer; CRC trans rs10242455 0.702 rs73403286 chr7:99154865 A/C cg09045935 chr12:6379348 NA 1.15 8.8 0.44 7.62e-17 Blood metabolite levels; CRC cis rs4680 1.000 rs4680 chr22:19951271 C/T cg23601416 chr22:19950040 COMT 0.29 7.89 0.4 4.6e-14 Blood metabolite levels; CRC trans rs5756813 0.635 rs4820301 chr22:38126364 G/A cg19894588 chr14:64061835 NA -0.58 -7.69 -0.39 1.71e-13 Optic cup area;Vertical cup-disc ratio; CRC trans rs9929218 0.954 rs7199991 chr16:68818245 T/G cg04657470 chr2:198365150 HSPE1;HSPD1 -0.8 -11.18 -0.52 8.13e-25 Colorectal cancer; CRC cis rs2032447 0.839 rs199750 chr6:26016462 A/G cg26028573 chr6:26043587 HIST1H2BB -0.5 -7.33 -0.37 1.77e-12 Intelligence (multi-trait analysis); CRC cis rs2276314 0.857 rs28396546 chr18:33639024 T/C cg19628046 chr18:33552617 C18orf21 0.57 7.81 0.4 7.57e-14 Endometriosis;Drug-induced torsades de pointes; CRC cis rs4237845 0.586 rs4760174 chr12:58320436 G/A cg02175503 chr12:58329896 NA 0.81 13.41 0.59 5.24e-33 Intelligence (multi-trait analysis); CRC cis rs12681287 0.640 rs13251006 chr8:87469105 C/T cg27223183 chr8:87520930 FAM82B -0.52 -7.47 -0.38 7.07e-13 Caudate activity during reward; CRC cis rs561341 1.000 rs1557731 chr17:30321567 T/G cg23018236 chr17:30244563 NA -0.6 -8.03 -0.4 1.74e-14 Hip circumference adjusted for BMI; CRC cis rs79349575 0.715 rs4793997 chr17:47019672 C/A cg00947319 chr17:47005597 UBE2Z -0.34 -5.89 -0.31 9.32e-9 Type 2 diabetes; CRC cis rs1577917 0.874 rs1838954 chr6:86565478 C/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.51 -6.81 -0.35 4.6e-11 Response to antipsychotic treatment; CRC cis rs11123170 0.640 rs1015754 chr2:113967990 T/C cg07772999 chr2:113993052 PAX8;LOC440839;LOC654433 -0.46 -6.1 -0.32 2.93e-9 Renal function-related traits (BUN); CRC cis rs2549003 1.000 rs10068129 chr5:131821246 A/G cg02551604 chr5:131831745 NA 0.54 8.37 0.42 1.68e-15 Asthma (sex interaction); CRC cis rs7937682 0.575 rs1940391 chr11:111776891 G/A cg09085632 chr11:111637200 PPP2R1B 0.91 15.82 0.66 2.59e-42 Primary sclerosing cholangitis; CRC cis rs17270561 0.553 rs9379784 chr6:25725506 A/G cg17691542 chr6:26056736 HIST1H1C 0.64 8.08 0.41 1.22e-14 Iron status biomarkers; CRC cis rs875971 1.000 rs12533997 chr7:65965377 A/G cg18876405 chr7:65276391 NA 0.51 8.78 0.44 9.39e-17 Aortic root size; CRC trans rs1997103 1.000 rs1997102 chr7:55399322 A/C cg20935933 chr6:143382018 AIG1 -0.51 -6.71 -0.35 8.55e-11 QRS interval (sulfonylurea treatment interaction); CRC trans rs559356 0.519 rs523810 chr3:34848023 G/A cg18960307 chr17:4699574 PSMB6 0.43 6.43 0.33 4.4e-10 Cognitive function; CRC trans rs2243480 1.000 rs781142 chr7:65438778 C/T cg10756647 chr7:56101905 PSPH 0.71 7.95 0.4 2.97e-14 Diabetic kidney disease; CRC cis rs6541297 0.938 rs7551742 chr1:230290118 A/G cg20703242 chr1:230279135 GALNT2 0.52 7.7 0.39 1.63e-13 Coronary artery disease; CRC cis rs864537 0.646 rs1723016 chr1:167433056 T/C cg09179987 chr1:167433047 CD247 0.56 8.84 0.44 5.72e-17 Celiac disease or Rheumatoid arthritis;Celiac disease; CRC trans rs1997103 1.000 rs6950311 chr7:55400990 G/A cg20935933 chr6:143382018 AIG1 0.52 6.72 0.35 7.8e-11 QRS interval (sulfonylurea treatment interaction); CRC cis rs11758351 0.518 rs79922979 chr6:26224975 A/G cg10723962 chr6:26240782 HIST1H4F -0.38 -6.13 -0.32 2.54e-9 Gout;Renal underexcretion gout; CRC trans rs7647973 0.593 rs58339610 chr3:49845006 T/A cg21659725 chr3:3221576 CRBN 0.66 7.32 0.37 1.88e-12 Menarche (age at onset); CRC cis rs6831352 0.819 rs1154401 chr4:100009738 G/C cg13256891 chr4:100009986 ADH5 0.54 7.66 0.39 2.11e-13 Alcohol dependence; CRC cis rs9372498 0.536 rs28605789 chr6:118889952 G/A cg18833306 chr6:118973337 C6orf204 0.45 5.84 0.31 1.24e-8 Diastolic blood pressure; CRC cis rs12760731 0.623 rs12691482 chr1:178421901 T/G cg00404053 chr1:178313656 RASAL2 0.7 8.73 0.43 1.31e-16 Obesity-related traits; CRC cis rs9584850 0.834 rs9584854 chr13:99118590 C/T cg20487152 chr13:99095054 FARP1 0.43 6.28 0.33 1.1e-9 Neuroticism; CRC cis rs3749237 0.595 rs2878298 chr3:49406080 T/C cg07636037 chr3:49044803 WDR6 0.55 8.1 0.41 1.08e-14 Resting heart rate; CRC cis rs2836974 0.836 rs1041440 chr21:40627325 C/T cg11644478 chr21:40555479 PSMG1 0.82 12.47 0.57 1.74e-29 Cognitive function; CRC cis rs597539 0.616 rs631001 chr11:68642974 C/T cg06112835 chr11:68658793 MRPL21 0.48 7.39 0.38 1.19e-12 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs6500395 0.925 rs16946342 chr16:48668542 G/A cg04672837 chr16:48644449 N4BP1 0.47 6.96 0.36 1.8e-11 Response to tocilizumab in rheumatoid arthritis; CRC cis rs58235267 0.591 rs4671457 chr2:63346356 C/T cg17519650 chr2:63277830 OTX1 0.45 6.19 0.32 1.83e-9 Prostate-specific antigen levels (conditioned on lead SNPs); CRC cis rs295137 0.836 rs10804097 chr2:201104924 A/T cg23649088 chr2:200775458 C2orf69 0.39 5.7 0.3 2.64e-8 Asthma (bronchodilator response); CRC cis rs742320 0.756 rs3765263 chr16:840378 A/G cg02106180 chr16:845767 CHTF18 0.56 9.13 0.45 7.23e-18 Mean corpuscular volume; CRC cis rs2842992 0.724 rs2273823 chr6:160211485 T/C cg16489826 chr6:160211363 TCP1;MRPL18 0.61 8.99 0.44 1.94e-17 Age-related macular degeneration (geographic atrophy); CRC cis rs10256972 0.706 rs12701969 chr7:1121849 A/G cg03923535 chr7:1197113 ZFAND2A 0.62 8.52 0.43 5.64e-16 Longevity;Endometriosis; CRC cis rs7615952 0.576 rs4646763 chr3:125822129 G/A cg05084668 chr3:125655381 ALG1L -0.45 -6.39 -0.33 5.72e-10 Blood pressure (smoking interaction); CRC cis rs13118159 0.550 rs4974611 chr4:1358449 T/C cg19318889 chr4:1322082 MAEA 0.69 10.13 0.49 3.56e-21 Longevity; CRC trans rs916888 0.773 rs199451 chr17:44801784 G/A cg23590916 chr17:43697445 MGC57346 0.7 7.11 0.36 7.2e-12 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs2836974 0.965 rs8130984 chr21:40639966 A/C cg11644478 chr21:40555479 PSMG1 0.81 12.32 0.56 5.9e-29 Cognitive function; CRC cis rs9911578 0.839 rs1871751 chr17:57190368 A/G cg05425664 chr17:57184151 TRIM37 -0.51 -8.15 -0.41 7.95e-15 Intelligence (multi-trait analysis); CRC cis rs8014671 0.552 rs4899359 chr14:71027964 G/A cg25576086 chr14:70833871 SYNJ2BP 0.37 6.13 0.32 2.51e-9 Prostate cancer; CRC cis rs738321 0.757 rs5750546 chr22:38542499 C/T cg25457927 chr22:38595422 NA -0.3 -5.97 -0.31 6e-9 Breast cancer; CRC cis rs7584330 0.554 rs75918156 chr2:238426287 G/A cg14458575 chr2:238380390 NA 0.46 6.51 0.34 2.8e-10 Prostate cancer; CRC cis rs12368653 0.591 rs1552842 chr12:58012163 A/G cg00677455 chr12:58241039 CTDSP2 0.39 5.64 0.3 3.74e-8 Multiple sclerosis; CRC cis rs9916302 0.904 rs11078915 chr17:37715426 T/C cg15445000 chr17:37608096 MED1 0.42 9.4 0.46 9.75e-19 Glomerular filtration rate (creatinine); CRC cis rs9549367 0.826 rs2302755 chr13:113898418 C/T cg00898013 chr13:113819073 PROZ -0.4 -5.72 -0.3 2.44e-8 Platelet distribution width; CRC cis rs17376456 0.825 rs28534784 chr5:93063332 C/A cg21475434 chr5:93447410 FAM172A 0.71 7.31 0.37 2.08e-12 Diabetic retinopathy; CRC cis rs7618915 0.501 rs34739010 chr3:52766122 A/G cg10802521 chr3:52805072 NEK4 -0.57 -8.87 -0.44 4.63e-17 Bipolar disorder; CRC cis rs780096 0.526 rs12476704 chr2:27613031 C/A cg24768116 chr2:27665128 KRTCAP3 -0.35 -7.65 -0.39 2.26e-13 Total body bone mineral density; CRC cis rs12410462 0.681 rs113984727 chr1:227553917 C/A cg23173402 chr1:227635558 NA 0.59 6.02 0.32 4.56e-9 Major depressive disorder; CRC cis rs910316 0.935 rs175076 chr14:75505486 A/G cg03030879 chr14:75389066 RPS6KL1 0.48 7.61 0.39 2.83e-13 Height; CRC cis rs4243830 0.737 rs7552172 chr1:6612269 C/T cg05709478 chr1:6581295 PLEKHG5 -0.57 -6.81 -0.35 4.6e-11 Body mass index; CRC cis rs9660992 0.573 rs12140703 chr1:205182865 G/C cg21643547 chr1:205240462 TMCC2 -0.38 -6.15 -0.32 2.19e-9 Mean corpuscular volume;Mean platelet volume; CRC cis rs2046867 0.908 rs62251640 chr3:72801605 T/C cg25664220 chr3:72788482 NA -0.46 -6.39 -0.33 5.8e-10 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; CRC cis rs208520 0.634 rs3909071 chr6:66836947 T/C cg07460842 chr6:66804631 NA -1.1 -15.0 -0.64 4.06e-39 Exhaled nitric oxide output; CRC trans rs1499614 1.000 rs2659903 chr7:66180931 G/A cg10756647 chr7:56101905 PSPH 0.76 7.97 0.4 2.69e-14 Gout; CRC cis rs1552244 1.000 rs56394721 chr3:10150795 A/G cg08888203 chr3:10149979 C3orf24 0.71 9.58 0.47 2.48e-19 Alzheimer's disease; CRC cis rs1728785 0.901 rs1183956 chr16:68606726 G/A cg02972257 chr16:68554789 NA -0.6 -7.52 -0.38 5.1e-13 Ulcerative colitis; CRC cis rs17666538 0.792 rs1669715 chr8:593641 T/C cg23958373 chr8:599963 NA 0.9 8.73 0.43 1.28e-16 IgG glycosylation; CRC trans rs7618501 0.633 rs11130228 chr3:50003246 C/T cg21665057 chr3:196295764 WDR53;FBXO45 0.58 9.27 0.46 2.53e-18 Intelligence (multi-trait analysis); CRC trans rs1814175 0.781 rs11040681 chr11:49981654 G/T cg15704280 chr7:45808275 SEPT13 -0.97 -18.82 -0.72 3.98e-54 Height; CRC cis rs3806843 0.735 rs801183 chr5:140091115 C/T cg19875535 chr5:140030758 IK 0.63 10.67 0.51 5.21e-23 Depressive symptoms (multi-trait analysis); CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg14489366 chr9:79521082 PRUNE2 -0.4 -6.19 -0.32 1.81e-9 Myopia (pathological); CRC cis rs6502050 0.799 rs12603050 chr17:80104631 A/G cg09264619 chr17:80180166 NA -0.34 -5.81 -0.3 1.5e-8 Life satisfaction; CRC cis rs208520 0.690 rs1776365 chr6:66834474 G/T cg07460842 chr6:66804631 NA -1.1 -15.01 -0.64 3.68e-39 Exhaled nitric oxide output; CRC cis rs12474201 0.862 rs7562173 chr2:46976217 C/G cg06386533 chr2:46925753 SOCS5 -0.75 -12.32 -0.56 6.05e-29 Height; CRC cis rs4713118 0.662 rs9468278 chr6:28028482 C/T cg12172441 chr6:28176163 NA 0.55 6.94 0.36 2.03e-11 Parkinson's disease; CRC cis rs672059 1.000 rs659307 chr1:183163078 G/A ch.1.3577855R chr1:183094577 LAMC1 0.48 6.95 0.36 1.95e-11 Hypertriglyceridemia; CRC cis rs7208859 0.673 rs11656845 chr17:29206164 G/T cg13385521 chr17:29058706 SUZ12P 0.68 7.94 0.4 3.16e-14 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg26400169 chr5:131131892 FNIP1 0.42 6.1 0.32 2.98e-9 Response to antipsychotic treatment; CRC cis rs9303401 0.659 rs12150536 chr17:56640834 C/T cg02118635 chr17:56770003 RAD51C;TEX14 0.78 9.44 0.46 6.87e-19 Cognitive test performance; CRC cis rs372883 0.600 rs2832293 chr21:30738872 C/G cg08807101 chr21:30365312 RNF160 0.59 8.41 0.42 1.23e-15 Pancreatic cancer; CRC cis rs9549367 0.789 rs3764124 chr13:113897320 C/T cg18105134 chr13:113819100 PROZ -0.74 -10.68 -0.51 4.61e-23 Platelet distribution width; CRC cis rs4927850 1.000 rs7630875 chr3:195753766 A/G cg00031303 chr3:195681400 NA 0.49 7.04 0.36 1.15e-11 Pancreatic cancer; CRC cis rs514406 0.565 rs897732 chr1:53382816 A/C cg25767906 chr1:53392781 SCP2 -0.49 -7.57 -0.39 3.82e-13 Monocyte count; CRC cis rs8060686 0.516 rs7197756 chr16:68275516 A/C cg26727032 chr16:67993705 SLC12A4 -0.65 -9.9 -0.48 2.12e-20 HDL cholesterol;Metabolic syndrome; CRC cis rs9926296 0.632 rs1800286 chr16:89869761 T/C cg27121462 chr16:89883253 FANCA 0.42 6.32 0.33 8.71e-10 Vitiligo; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg25582403 chr17:37844421 ERBB2;PGAP3 0.43 6.22 0.32 1.54e-9 Intelligence (multi-trait analysis); CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg26398333 chr1:153895721 GATAD2B 0.46 6.0 0.31 5.15e-9 Thyroid stimulating hormone; CRC cis rs6502050 0.835 rs8065981 chr17:80091393 G/T cg22110888 chr17:80059540 CCDC57 0.4 6.36 0.33 6.76e-10 Life satisfaction; CRC cis rs1129187 0.902 rs6907751 chr6:42944850 C/T cg02353165 chr6:42928485 GNMT 0.91 18.22 0.71 8.94e-52 Alzheimer's disease in APOE e4+ carriers; CRC cis rs6502050 0.835 rs7406529 chr17:80080877 C/T cg22110888 chr17:80059540 CCDC57 -0.41 -6.46 -0.34 3.81e-10 Life satisfaction; CRC cis rs17065868 0.649 rs1053948 chr13:45008333 G/C cg10246903 chr13:45222710 NA 0.56 6.21 0.32 1.64e-9 Antineutrophil cytoplasmic antibody-associated vasculitis; CRC cis rs826838 1.000 rs11514441 chr12:38775190 C/T cg26384229 chr12:38710491 ALG10B 0.75 10.56 0.5 1.25e-22 Heart rate; CRC cis rs79057730 0.528 rs4719313 chr7:822501 C/T cg11064039 chr7:766100 PRKAR1B;HEATR2 0.68 6.85 0.35 3.71e-11 Initial pursuit acceleration; CRC cis rs13118159 0.899 rs3796613 chr4:1353321 A/T cg21620606 chr4:1342894 KIAA1530 0.48 8.41 0.42 1.31e-15 Longevity; CRC cis rs8177253 0.965 rs4854762 chr3:133499063 A/G cg11941060 chr3:133502564 NA 0.57 9.81 0.48 4.4e-20 Iron status biomarkers; CRC cis rs2153535 0.580 rs1577471 chr6:8485905 T/A cg07606381 chr6:8435919 SLC35B3 0.68 10.89 0.51 8.84e-24 Motion sickness; CRC trans rs1728785 0.901 rs11075688 chr16:68655924 A/G cg04657470 chr2:198365150 HSPE1;HSPD1 -0.72 -8.78 -0.44 9.14e-17 Ulcerative colitis; CRC cis rs9814567 1.000 rs4955555 chr3:134286427 C/T cg06541857 chr3:134203789 ANAPC13;CEP63 -0.4 -5.98 -0.31 5.95e-9 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs11971779 0.680 rs7795520 chr7:139079207 A/G cg07862535 chr7:139043722 LUC7L2 0.57 7.35 0.38 1.61e-12 Diisocyanate-induced asthma; CRC cis rs10751667 0.621 rs10794351 chr11:946228 C/T cg23136738 chr11:925521 AP2A2 -0.42 -7.07 -0.36 9.13e-12 Alzheimer's disease (late onset); CRC cis rs6461049 0.765 rs4719431 chr7:2140312 T/C cg02951883 chr7:2050386 MAD1L1 -0.6 -9.89 -0.48 2.36e-20 Schizophrenia; CRC cis rs9549367 0.713 rs3024757 chr13:113823186 G/T cg00898013 chr13:113819073 PROZ -0.58 -8.31 -0.42 2.63e-15 Platelet distribution width; CRC cis rs753955 0.592 rs4769288 chr13:24360434 T/G cg25267304 chr13:24462978 PCOTH;MIPEP -0.44 -6.22 -0.32 1.53e-9 Lung cancer; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg24159451 chr19:9938429 UBL5 0.52 7.41 0.38 1.04e-12 Response to antipsychotic treatment; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg22150397 chr12:82752718 CCDC59;C12orf26 0.44 7.46 0.38 7.73e-13 Liver disease severity in Alagille syndrome; CRC cis rs25422 0.887 rs9320666 chr6:118989181 C/T cg22561889 chr6:118971681 C6orf204 0.44 6.13 0.32 2.48e-9 Renal cell carcinoma; CRC trans rs8002861 0.664 rs4942246 chr13:44404853 A/G cg17145862 chr1:211918768 LPGAT1 0.58 10.07 0.49 5.66e-21 Leprosy; CRC cis rs7550918 1 rs7550918 chr1:247675559 C/T cg21399703 chr1:247681439 NA -0.53 -9.9 -0.48 2.12e-20 Platelet count; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg18638793 chr12:108908854 FICD 0.43 6.1 0.32 2.9e-9 Response to antipsychotic treatment; CRC cis rs6835098 1.000 rs4561909 chr4:174086937 A/T cg08422745 chr4:174089978 GALNT7 -0.99 -14.97 -0.64 5.4e-39 Dementia and core Alzheimer's disease neuropathologic changes; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg03226245 chr19:36486125 SDHAF1 0.41 5.98 0.31 5.81e-9 Intelligence (multi-trait analysis); CRC cis rs57221529 0.600 rs11750269 chr5:666270 G/A cg09021430 chr5:549028 NA -0.72 -7.55 -0.38 4.37e-13 Lung disease severity in cystic fibrosis; CRC cis rs9467773 0.620 rs1490488 chr6:26614808 T/C cg09904177 chr6:26538194 HMGN4 0.72 11.24 0.53 5.19e-25 Intelligence (multi-trait analysis); CRC cis rs12325245 0.536 rs12931051 chr16:58626534 C/T cg02549819 chr16:58548995 SETD6 1.2 7.97 0.4 2.72e-14 Schizophrenia; CRC cis rs897984 0.609 rs732173 chr16:31050023 C/A cg02466173 chr16:30829666 NA -0.66 -10.11 -0.49 4.1e-21 Dementia with Lewy bodies; CRC cis rs7584330 0.910 rs880930 chr2:238396872 G/C cg16989719 chr2:238392110 NA -0.42 -7.65 -0.39 2.27e-13 Prostate cancer; CRC cis rs11229555 0.609 rs12291791 chr11:58186290 C/T cg15696309 chr11:58395628 NA -0.81 -10.31 -0.49 8.83e-22 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; CRC cis rs6912958 0.559 rs445434 chr6:88041849 A/G cg12350822 chr6:88032061 C6orf162;GJB7 0.51 10.21 0.49 1.9e-21 Monocyte percentage of white cells; CRC cis rs2404602 0.646 rs3764245 chr15:77223176 G/C cg23625390 chr15:77176239 SCAPER 0.79 11.66 0.54 1.52e-26 Blood metabolite levels; CRC cis rs6952808 0.656 rs73048919 chr7:2103637 C/A cg02951883 chr7:2050386 MAD1L1 -0.73 -11.21 -0.53 6.53e-25 Bipolar disorder and schizophrenia; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg04296778 chr1:94344488 DNTTIP2 0.41 6.02 0.31 4.53e-9 Intelligence (multi-trait analysis); CRC trans rs8073060 0.586 rs2428464 chr17:34021994 C/G cg19694781 chr19:47549865 TMEM160 -1.06 -14.24 -0.62 3.54e-36 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; CRC cis rs9811920 0.599 rs61148087 chr3:99539891 C/A cg07805332 chr3:99536008 MIR548G;C3orf26 0.54 8.15 0.41 7.6e-15 Axial length; CRC cis rs4731207 0.565 rs7780392 chr7:124575655 C/T cg23710748 chr7:124431027 NA -0.39 -6.19 -0.32 1.8e-9 Cutaneous malignant melanoma; CRC cis rs12142240 0.692 rs7529674 chr1:46818508 T/C cg14993813 chr1:46806288 NSUN4 -0.48 -6.15 -0.32 2.24e-9 Menopause (age at onset); CRC cis rs2836974 0.623 rs34240248 chr21:40685239 A/G cg11890956 chr21:40555474 PSMG1 -0.86 -13.73 -0.6 3.08e-34 Cognitive function; CRC cis rs1046896 0.503 rs12947062 chr17:80686370 A/G cg08200770 chr17:80723486 TBCD 0.42 7.19 0.37 4.25e-12 Glycated hemoglobin levels; CRC trans rs1455244 0.700 rs7229302 chr18:11508904 G/T cg07382149 chr1:150601807 ENSA 0.42 6.47 0.34 3.46e-10 Schizophrenia; CRC cis rs10751667 1.000 rs10794349 chr11:945678 T/C cg23136738 chr11:925521 AP2A2 -0.53 -8.51 -0.42 6.18e-16 Alzheimer's disease (late onset); CRC cis rs597539 0.615 rs629426 chr11:68671104 A/G cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.89 15.15 0.64 1.07e-39 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs7044106 0.762 rs7849566 chr9:123460769 A/C cg09419670 chr9:123605666 PSMD5;LOC253039 0.7 10.61 0.5 8.3e-23 Hip circumference adjusted for BMI; CRC cis rs7517126 1.000 rs2133138 chr1:196843171 A/G cg13682187 chr1:196946512 CFHR5 0.34 5.68 0.3 3e-8 Blood protein levels; CRC cis rs10464366 0.843 rs12701691 chr7:39090177 T/G cg18850127 chr7:39170497 POU6F2 0.49 6.38 0.33 6.02e-10 IgG glycosylation; CRC cis rs6701037 0.625 rs67332874 chr1:175128537 G/A cg14847009 chr1:175162515 KIAA0040 -0.27 -5.85 -0.31 1.21e-8 Alcohol dependence; CRC cis rs939658 0.805 rs34478496 chr15:79440997 C/A cg17916960 chr15:79447300 NA -0.44 -7.1 -0.36 7.67e-12 Refractive error; CRC cis rs12936587 0.748 rs12939297 chr17:17524247 G/A cg09796270 chr17:17721594 SREBF1 -0.41 -5.91 -0.31 8.57e-9 Hip circumference;Coronary artery disease or large artery stroke;Coronary heart disease;Coronary artery disease; CRC cis rs28386778 0.897 rs2665833 chr17:61906846 T/C cg23090583 chr17:61904693 PSMC5;FTSJ3 1.05 20.84 0.75 4.55e-62 Prudent dietary pattern; CRC cis rs2836974 0.555 rs35909862 chr21:40621158 G/A cg11644478 chr21:40555479 PSMG1 -0.69 -11.03 -0.52 2.67e-24 Cognitive function; CRC trans rs2228479 0.850 rs11649100 chr16:89798179 A/G cg24644049 chr4:85504048 CDS1 0.9 7.37 0.38 1.39e-12 Skin colour saturation; CRC cis rs9768139 0.708 rs896782 chr7:158114115 G/A cg06219351 chr7:158114137 PTPRN2 -0.6 -9.53 -0.47 3.61e-19 Calcium levels; CRC cis rs7811142 0.830 rs6948685 chr7:99970188 C/T cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.61 7.77 0.39 9.87e-14 Platelet count; CRC trans rs6952808 0.771 rs10244946 chr7:1921068 A/G cg04565464 chr8:145669602 NFKBIL2 -0.41 -6.17 -0.32 2.04e-9 Bipolar disorder and schizophrenia; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg04674497 chr6:45346044 SUPT3H;RUNX2 0.43 6.28 0.33 1.1e-9 Intelligence (multi-trait analysis); CRC cis rs6952808 0.862 rs4721167 chr7:1933224 C/T cg21782813 chr7:2030301 MAD1L1 0.47 8.17 0.41 6.59e-15 Bipolar disorder and schizophrenia; CRC trans rs9956878 0.555 rs8085188 chr18:73544676 A/G cg24760647 chr2:220408209 TMEM198;CHPF -0.4 -6.05 -0.32 3.92e-9 Obesity-related traits; CRC cis rs59104589 0.617 rs59487360 chr2:242270433 A/G cg19488206 chr2:242435732 STK25 0.46 6.4 0.33 5.31e-10 Fibrinogen levels; CRC cis rs2153535 0.601 rs4960414 chr6:8438541 A/G cg21535247 chr6:8435926 SLC35B3 0.48 7.26 0.37 2.78e-12 Motion sickness; CRC cis rs4665809 0.590 rs2289019 chr2:26420809 G/C cg26119090 chr2:26468346 HADHA;HADHB -1.05 -15.29 -0.64 3.04e-40 Gut microbiome composition (summer); CRC trans rs116095464 0.558 rs112343653 chr5:257174 G/A cg00938859 chr5:1591904 SDHAP3 0.73 7.89 0.4 4.53e-14 Breast cancer; CRC cis rs270601 0.661 rs10036208 chr5:131571323 T/C cg11843238 chr5:131593191 PDLIM4 0.55 9.76 0.47 6.4e-20 Acylcarnitine levels; CRC trans rs2228479 0.867 rs57940434 chr16:89975496 G/A cg21302420 chr1:112162376 RAP1A 0.65 6.41 0.33 5.02e-10 Skin colour saturation; CRC cis rs12549902 0.966 rs4317621 chr8:41516581 A/G cg17182837 chr8:41585554 ANK1 -0.35 -5.76 -0.3 1.92e-8 Corrected insulin response;Corrected insulin response adjusted for insulin sensitivity index;Insulin levels adjusted for BMI;Type 2 diabetes; CRC cis rs10256972 0.591 rs10229680 chr7:1158565 C/T cg18765753 chr7:1198926 ZFAND2A -0.4 -6.7 -0.35 9.12e-11 Longevity;Endometriosis; CRC cis rs9287719 0.967 rs6709466 chr2:10748257 T/C cg00105475 chr2:10696890 NA 0.45 7.17 0.37 4.87e-12 Prostate cancer; CRC cis rs9462027 0.628 rs6457795 chr6:34819366 G/A cg07306190 chr6:34760872 UHRF1BP1 -0.34 -6.07 -0.32 3.52e-9 Systemic lupus erythematosus; CRC cis rs4076764 0.846 rs4255362 chr1:163424630 G/A cg24596788 chr1:163392923 NA -0.57 -8.93 -0.44 3.13e-17 Motion sickness; CRC cis rs9463078 0.605 rs10948188 chr6:44926212 G/A cg25276700 chr6:44698697 NA 0.26 6.24 0.33 1.38e-9 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; CRC cis rs9409565 0.559 rs9409774 chr9:97241983 G/A cg04523069 chr9:97136363 HIATL1 0.43 5.88 0.31 9.92e-9 Colorectal cancer (alcohol consumption interaction); CRC cis rs76533333 0.646 rs71446628 chr13:113393611 C/T cg04656015 chr13:113407548 ATP11A 0.75 5.73 0.3 2.22e-8 Red cell distribution width; CRC cis rs375066 0.934 rs2191564 chr19:44367611 T/C cg12072164 chr19:44306565 LYPD5 0.37 5.61 0.3 4.31e-8 Breast cancer; CRC cis rs1008375 1.000 rs17507481 chr4:17620066 A/G cg16339924 chr4:17578868 LAP3 0.54 7.28 0.37 2.54e-12 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs9894429 0.538 rs9747080 chr17:79606704 A/G cg09655341 chr17:79618100 PDE6G -0.39 -7.03 -0.36 1.21e-11 Eye color traits; CRC cis rs10504229 0.645 rs6995814 chr8:58114159 C/T cg02725872 chr8:58115012 NA -0.65 -11.61 -0.54 2.34e-26 Developmental language disorder (linguistic errors); CRC cis rs7772486 0.790 rs3924498 chr6:146233338 A/T cg23711669 chr6:146136114 FBXO30 -0.72 -12.76 -0.58 1.48e-30 Lobe attachment (rater-scored or self-reported); CRC cis rs7917772 0.636 rs7897384 chr10:104529042 T/G cg04362960 chr10:104952993 NT5C2 0.46 6.11 0.32 2.84e-9 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC cis rs13144136 0.664 rs12501252 chr4:10661563 A/G cg10242279 chr4:10666415 CLNK -0.37 -6.41 -0.33 4.94e-10 Resistance to antihypertensive treatment in hypertension; CRC cis rs7512552 0.839 rs2873669 chr1:150426224 C/T cg15654264 chr1:150340011 RPRD2 -0.59 -8.23 -0.41 4.34e-15 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); CRC cis rs7680126 0.633 rs17389602 chr4:10206926 T/A cg00071950 chr4:10020882 SLC2A9 -0.53 -6.65 -0.34 1.19e-10 Urate levels in lean individuals;Urate levels in overweight individuals;Urate levels in obese individuals; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg00139244 chr10:31608402 ZEB1;LOC220930 0.32 6.11 0.32 2.85e-9 Liver disease severity in Alagille syndrome; CRC cis rs4721295 0.502 rs2058430 chr7:2206110 A/G cg02951883 chr7:2050386 MAD1L1 -0.58 -8.36 -0.42 1.84e-15 Schizophrenia, schizoaffective disorder or bipolar disorder; CRC cis rs77372450 0.636 rs10072471 chr5:157022207 G/C cg25387487 chr5:157003181 ADAM19 -0.39 -5.68 -0.3 3.03e-8 Bipolar disorder (body mass index interaction); CRC cis rs11758351 0.715 rs76130408 chr6:26208962 A/G cg22723502 chr6:26240528 HIST1H4F -0.38 -6.11 -0.32 2.79e-9 Gout;Renal underexcretion gout; CRC cis rs7811142 0.943 rs66958101 chr7:100074020 G/A cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.61 7.8 0.4 8.28e-14 Platelet count; CRC cis rs1552244 1.000 rs1552244 chr3:10135577 A/G cg18598329 chr3:10140678 FANCD2;C3orf24 -0.9 -12.82 -0.58 8.43e-31 Alzheimer's disease; CRC cis rs7937682 1.000 rs11608149 chr11:111535102 G/A cg19812747 chr11:111475976 SIK2 0.52 8.13 0.41 8.69e-15 Primary sclerosing cholangitis; CRC cis rs1577917 0.958 rs6921315 chr6:86471668 G/A cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.52 -7.11 -0.36 7.42e-12 Response to antipsychotic treatment; CRC cis rs9914988 0.943 rs3181215 chr17:27077331 C/T cg20469991 chr17:27169893 C17orf63 0.48 5.92 0.31 8.01e-9 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs951366 0.789 rs823094 chr1:205689807 G/T cg14159672 chr1:205819179 PM20D1 -0.7 -10.71 -0.51 3.58e-23 Menarche (age at onset); CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg23429981 chr6:97345948 NDUFAF4 0.39 6.46 0.34 3.75e-10 Obesity-related traits; CRC cis rs4964805 0.632 rs9706225 chr12:104188086 T/C cg02344784 chr12:104178138 NT5DC3 0.79 15.0 0.64 4.21e-39 Attention deficit hyperactivity disorder; CRC trans rs61931739 0.500 rs7963282 chr12:34535255 A/C cg13010199 chr12:38710504 ALG10B 0.45 6.52 0.34 2.65e-10 Morning vs. evening chronotype; CRC cis rs9372498 0.536 rs9481821 chr6:118846022 A/C cg24463073 chr6:118973353 C6orf204 0.51 6.87 0.35 3.16e-11 Diastolic blood pressure; CRC cis rs6952808 1.000 rs10233560 chr7:1885415 T/C cg21782813 chr7:2030301 MAD1L1 0.42 7.26 0.37 2.87e-12 Bipolar disorder and schizophrenia; CRC cis rs6952808 0.531 rs3800922 chr7:2184505 A/G cg02951883 chr7:2050386 MAD1L1 -0.62 -9.22 -0.45 3.73e-18 Bipolar disorder and schizophrenia; CRC cis rs7639513 0.591 rs9849171 chr3:12622623 G/C cg23032965 chr3:12705835 RAF1 0.54 8.0 0.4 2.09e-14 Itch intensity from mosquito bite; CRC cis rs9527 0.590 rs2148198 chr10:104915310 A/G cg15744005 chr10:104629667 AS3MT 0.3 5.65 0.3 3.46e-8 Arsenic metabolism; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg19319088 chr7:6388563 C7orf70 0.38 6.19 0.32 1.84e-9 Liver disease severity in Alagille syndrome; CRC trans rs12702919 0.869 rs10237257 chr7:9553854 G/A cg15597424 chr4:24472487 NA -0.39 -6.19 -0.32 1.83e-9 PR interval in Tripanosoma cruzi seropositivity; CRC trans rs916888 0.821 rs199525 chr17:44847834 T/G cg22968622 chr17:43663579 NA 1.45 18.09 0.71 2.95e-51 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs6121246 0.567 rs6058187 chr20:30190923 T/C cg13852791 chr20:30311386 BCL2L1 0.6 8.21 0.41 5.04e-15 Mean corpuscular hemoglobin; CRC trans rs1814175 0.692 rs1851873 chr11:49937767 A/G cg15704280 chr7:45808275 SEPT13 -0.75 -12.23 -0.56 1.28e-28 Height; CRC cis rs7666738 0.830 rs969049 chr4:98988857 C/T cg05340658 chr4:99064831 C4orf37 0.6 9.42 0.46 8.39e-19 Colonoscopy-negative controls vs population controls; CRC cis rs1882538 0.596 rs10281827 chr7:133081810 A/G cg10665199 chr7:133106180 EXOC4 0.67 10.53 0.5 1.59e-22 Intelligence (multi-trait analysis); CRC trans rs7618501 1.000 rs9859153 chr3:49807085 G/T cg21659725 chr3:3221576 CRBN 0.91 17.27 0.69 4.93e-48 Intelligence (multi-trait analysis); CRC cis rs4662945 0.603 rs10496678 chr2:130262209 C/T cg05962382 chr2:130345044 NA -0.49 -8.67 -0.43 1.97e-16 Response to cytidine analogues (gemcitabine); CRC cis rs2836950 0.545 rs2836940 chr21:40588696 T/C cg06238570 chr21:40685208 BRWD1 -0.6 -8.74 -0.43 1.23e-16 Menarche (age at onset); CRC cis rs875971 0.862 rs7783779 chr7:65796626 A/G cg11764359 chr7:65958608 NA -0.6 -8.83 -0.44 6.42e-17 Aortic root size; CRC cis rs7647973 1.000 rs62259947 chr3:49439924 T/C cg20833759 chr3:49053208 WDR6;DALRD3 -0.62 -9.27 -0.46 2.46e-18 Menarche (age at onset); CRC cis rs3015497 0.789 rs10133849 chr14:51121700 A/G cg09863266 chr14:51125203 SAV1 -0.32 -6.02 -0.31 4.68e-9 Mean platelet volume; CRC cis rs9910055 0.683 rs7220138 chr17:42254011 C/G cg10896456 chr17:42255109 ASB16;C17orf65 0.45 7.67 0.39 2.02e-13 Total body bone mineral density; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg13482236 chr15:59062977 FAM63B 0.45 6.25 0.33 1.28e-9 Response to antipsychotic treatment; CRC cis rs875971 0.825 rs1860472 chr7:66082723 T/C cg18252515 chr7:66147081 NA 0.43 6.14 0.32 2.35e-9 Aortic root size; CRC cis rs11098499 0.908 rs2017057 chr4:120257711 A/G cg24375607 chr4:120327624 NA 0.49 7.57 0.39 3.78e-13 Corneal astigmatism; CRC cis rs9868809 0.881 rs13063312 chr3:48661985 G/A cg00383909 chr3:49044727 WDR6 0.78 7.8 0.4 8.09e-14 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; CRC cis rs6952808 0.601 rs3800882 chr7:2120758 G/A cg21782813 chr7:2030301 MAD1L1 0.47 8.53 0.43 5.44e-16 Bipolar disorder and schizophrenia; CRC cis rs7429990 0.932 rs34025851 chr3:47953733 C/A cg11946769 chr3:48343235 NME6 0.46 5.9 0.31 8.99e-9 Educational attainment (years of education); CRC trans rs1455244 0.700 rs7229302 chr18:11508904 G/T cg21963318 chr16:85832920 COX4I1;COX4NB 0.43 6.63 0.34 1.41e-10 Schizophrenia; CRC trans rs7618501 0.633 rs9814664 chr3:50078541 C/T cg21659725 chr3:3221576 CRBN -0.55 -8.63 -0.43 2.71e-16 Intelligence (multi-trait analysis); CRC cis rs12997796 0.556 rs35129240 chr2:86929217 G/A cg25203885 chr2:87302643 LOC285074 -0.58 -5.87 -0.31 1.09e-8 Schizophrenia; CRC cis rs344364 0.511 rs1742460 chr16:1945441 G/C cg03013636 chr16:1946785 NA 0.58 6.66 0.34 1.15e-10 Glomerular filtration rate in chronic kidney disease; CRC cis rs6570726 0.764 rs9399553 chr6:145873664 A/T cg05347473 chr6:146136440 FBXO30 0.4 6.12 0.32 2.66e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs858239 0.712 rs200717 chr7:23392271 A/G cg00469287 chr7:23338798 C7orf30 0.43 5.99 0.31 5.51e-9 Cerebrospinal fluid biomarker levels; CRC cis rs6570726 0.791 rs440477 chr6:145854188 C/T cg23711669 chr6:146136114 FBXO30 0.75 13.11 0.59 7.31e-32 Lobe attachment (rater-scored or self-reported); CRC cis rs79057730 0.599 rs4333501 chr7:803244 C/T cg11064039 chr7:766100 PRKAR1B;HEATR2 0.67 7.4 0.38 1.17e-12 Initial pursuit acceleration; CRC cis rs1577917 0.958 rs12660846 chr6:86573809 T/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.5 -6.54 -0.34 2.31e-10 Response to antipsychotic treatment; CRC cis rs3733585 0.699 rs17245723 chr4:9962218 A/T cg00071950 chr4:10020882 SLC2A9 -0.55 -9.78 -0.47 5.41e-20 Cleft plate (environmental tobacco smoke interaction); CRC cis rs847577 0.646 rs10270222 chr7:97781799 C/T cg21770322 chr7:97807741 LMTK2 -0.67 -12.26 -0.56 1.01e-28 Breast cancer; CRC cis rs6582630 0.537 rs1829579 chr12:38420555 A/G cg13010199 chr12:38710504 ALG10B 0.47 6.32 0.33 8.32e-10 Drug-induced liver injury (flucloxacillin); CRC cis rs28374715 0.681 rs11629979 chr15:41626579 A/G cg18705301 chr15:41695430 NDUFAF1 -0.85 -14.32 -0.62 1.68e-36 Ulcerative colitis; CRC cis rs6540559 1.000 rs742215 chr1:209961023 A/T cg23283495 chr1:209979779 IRF6 0.44 6.92 0.36 2.33e-11 Cleft lip with or without cleft palate; CRC cis rs7089973 0.624 rs17586888 chr10:116598121 T/C cg23260525 chr10:116636907 FAM160B1 0.35 8.12 0.41 9.56e-15 Bipolar disorder or attention deficit hyperactivity disorder; CRC cis rs7044106 0.762 rs3903886 chr9:123383646 A/G cg09419670 chr9:123605666 PSMD5;LOC253039 -0.71 -11.94 -0.55 1.51e-27 Hip circumference adjusted for BMI; CRC cis rs3736485 0.816 rs12443362 chr15:51874542 C/A cg08986416 chr15:51914746 DMXL2 -0.48 -6.92 -0.36 2.39e-11 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs524023 0.958 rs12802649 chr11:64359627 C/T cg06522879 chr11:64358276 SLC22A12 -0.59 -9.38 -0.46 1.11e-18 Urate levels in obese individuals; CRC cis rs4713118 0.513 rs149954 chr6:28035246 G/A cg02683197 chr6:28174875 NA 0.62 8.57 0.43 4.07e-16 Parkinson's disease; CRC cis rs6541297 1.000 rs4846909 chr1:230285372 G/A cg20703242 chr1:230279135 GALNT2 0.53 8.18 0.41 6.37e-15 Coronary artery disease; CRC cis rs7289126 0.966 rs2284072 chr22:38633666 A/C cg25457927 chr22:38595422 NA -0.3 -5.76 -0.3 1.89e-8 Mammographic density (dense area);Percent mammographic density; CRC cis rs6142102 0.961 rs1883524 chr20:32626107 G/A cg08999081 chr20:33150536 PIGU 0.37 5.64 0.3 3.6e-8 Skin pigmentation; CRC cis rs2836974 0.965 rs7354783 chr21:40652992 G/A cg11644478 chr21:40555479 PSMG1 0.81 12.32 0.56 6.05e-29 Cognitive function; CRC cis rs1865760 0.786 rs1436308 chr6:25939567 T/G cg17691542 chr6:26056736 HIST1H1C 0.54 7.75 0.39 1.14e-13 Height; CRC cis rs370915 0.607 rs28548850 chr4:187786716 G/A cg12892747 chr4:187813459 NA -0.56 -8.04 -0.41 1.67e-14 Gout; CRC trans rs2303319 0.504 rs62189054 chr2:162624654 C/G cg03774468 chr3:140950104 ACPL2 -0.65 -6.07 -0.32 3.46e-9 Cognitive function; CRC cis rs847577 0.506 rs7808528 chr7:97721425 G/T cg21770322 chr7:97807741 LMTK2 0.85 19.36 0.73 2.8e-56 Breast cancer; CRC cis rs11148252 0.574 rs61958118 chr13:53170226 C/T cg02158880 chr13:53174818 NA 0.59 9.39 0.46 1.05e-18 Lewy body disease; CRC cis rs6426558 0.524 rs2813948 chr1:227459621 A/T cg10327440 chr1:227177885 CDC42BPA 0.43 6.39 0.33 5.8e-10 Neutrophil percentage of white cells; CRC cis rs780094 0.544 rs2303370 chr2:27651375 C/T cg12000995 chr2:27665139 KRTCAP3 -0.28 -5.84 -0.31 1.26e-8 Calcium levels;Fasting blood insulin;Metabolic traits;Triglyceride levels;Fasting plasma glucose;Urate levels in overweight individuals;Urate levels in obese individuals;Uric acid levels;Height;Age-related diseases, mortality and associated endophenotypes;Renal underexcretion gout;Fasting blood glucose (BMI interaction);Urate levels;Gondoic acid (20:1n-9) levels;Fasting blood insulin (BMI interaction);Triglycerides;Plasma omega-3 polyunsaturated fatty acid levels (docosapentaenoic acid);Type 2 diabetes;Nonalcoholic fatty liver disease;Hypertriglyceridemia;C-reactive protein;Age-related disease endophenotypes;LDL cholesterol;Metabolic syndrome;Crohn's disease;Alcohol consumption (drinks per week);Homeostasis model assessment of insulin resistance;Alcohol consumption;Red blood cell count;Fasting blood glucose; CRC cis rs7666738 0.830 rs4345191 chr4:98945408 A/G cg17366294 chr4:99064904 C4orf37 0.43 7.34 0.38 1.69e-12 Colonoscopy-negative controls vs population controls; CRC cis rs11190604 0.767 rs74869390 chr10:102189385 A/G cg16342193 chr10:102329863 NA -0.37 -6.0 -0.31 5.3300000000000004e-09 Palmitoleic acid (16:1n-7) levels; CRC cis rs11098499 0.863 rs13134665 chr4:120426430 T/C cg09307838 chr4:120376055 NA 0.68 10.3 0.49 9.17e-22 Corneal astigmatism; CRC trans rs66573146 0.572 rs66734745 chr4:6948765 T/C cg07817883 chr1:32538562 TMEM39B 1.11 11.97 0.55 1.19e-27 Granulocyte percentage of myeloid white cells; CRC cis rs6502050 0.835 rs35555954 chr17:80122438 T/C cg22110888 chr17:80059540 CCDC57 0.41 6.39 0.33 5.61e-10 Life satisfaction; CRC cis rs7727544 0.669 rs113823725 chr5:131563501 C/G cg12564285 chr5:131593104 PDLIM4 0.39 7.27 0.37 2.7e-12 Blood metabolite levels; CRC cis rs2839186 0.500 rs13052701 chr21:47660045 A/T cg20399509 chr21:47717575 C21orf57 -0.39 -6.31 -0.33 9.21e-10 Testicular germ cell tumor; CRC cis rs11764590 0.715 rs9969125 chr7:2088460 C/T cg23422044 chr7:1970798 MAD1L1 -0.52 -6.19 -0.32 1.76e-9 Neuroticism; CRC cis rs12024301 0.557 rs12029935 chr1:183588983 G/A cg11505048 chr1:183622726 RGL1;APOBEC4 0.76 6.93 0.36 2.16e-11 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs1555895 0.576 rs2274376 chr10:850157 A/G cg10556349 chr10:835070 NA -0.37 -7.0 -0.36 1.48e-11 Survival in rectal cancer; CRC trans rs670292 0.564 rs607971 chr6:150677754 A/C cg11381792 chr21:45432451 TRAPPC10 0.44 6.23 0.32 1.43e-9 Anger; CRC cis rs7726839 0.507 rs60068988 chr5:597668 T/C cg16447950 chr5:562315 NA -0.73 -9.65 -0.47 1.41e-19 Obesity-related traits; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg22924680 chr5:43557135 PAIP1 -0.39 -6.09 -0.32 3.18e-9 Myopia (pathological); CRC cis rs798554 0.679 rs2527677 chr7:2882621 A/G cg13628971 chr7:2884303 GNA12 0.61 8.32 0.42 2.34e-15 Height; CRC cis rs6121246 0.909 rs1075698 chr20:30387992 G/C cg13852791 chr20:30311386 BCL2L1 0.72 11.33 0.53 2.39e-25 Mean corpuscular hemoglobin; CRC cis rs3733585 0.673 rs4407505 chr4:9953367 T/G cg00071950 chr4:10020882 SLC2A9 -0.55 -9.74 -0.47 7.09e-20 Cleft plate (environmental tobacco smoke interaction); CRC cis rs9463078 0.774 rs4373351 chr6:45276324 T/C cg25276700 chr6:44698697 NA -0.28 -6.71 -0.35 8.73e-11 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; CRC cis rs10504229 0.595 rs79077737 chr8:58117520 G/A cg22535103 chr8:58192502 C8orf71 -0.7 -9.24 -0.45 3.14e-18 Developmental language disorder (linguistic errors); CRC cis rs7584330 0.740 rs13426236 chr2:238447940 A/G cg14458575 chr2:238380390 NA 0.54 8.92 0.44 3.34e-17 Prostate cancer; CRC trans rs1656966 1.000 rs1656966 chr3:186466252 C/T cg14213021 chr10:71930531 SAR1A 0.41 6.33 0.33 8.01e-10 Myopia (pathological); CRC cis rs6951245 0.872 rs74360401 chr7:1067403 G/A cg21664854 chr7:1097933 C7orf50;GPR146 0.79 8.92 0.44 3.39e-17 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs7301016 0.846 rs73126024 chr12:63027764 C/T cg11441379 chr12:63026424 NA 0.54 5.65 0.3 3.47e-8 IgG glycosylation; CRC cis rs10045504 0.502 rs17352751 chr5:38737836 G/A cg15396434 chr5:38725168 NA -0.6 -5.99 -0.31 5.54e-9 Night sleep phenotypes; CRC cis rs8060686 0.920 rs73593810 chr16:67866783 C/T cg04539111 chr16:67997858 SLC12A4 -0.48 -5.75 -0.3 2.07e-8 HDL cholesterol;Metabolic syndrome; CRC cis rs9925964 0.933 rs881929 chr16:31079371 G/T cg02466173 chr16:30829666 NA 0.43 5.82 0.31 1.41e-8 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs5769765 0.955 rs9616367 chr22:50303515 A/C cg22709217 chr22:50311962 ALG12;CRELD2 -1.01 -16.54 -0.67 3.83e-45 Schizophrenia; CRC cis rs10193935 0.901 rs59890734 chr2:42595662 G/A cg27598129 chr2:42591480 NA -0.72 -7.91 -0.4 3.84e-14 Colonoscopy-negative controls vs population controls; CRC cis rs3749237 0.595 rs7643845 chr3:49530711 A/G cg07636037 chr3:49044803 WDR6 0.55 8.01 0.4 2.07e-14 Resting heart rate; CRC cis rs1580019 0.885 rs3801331 chr7:32497039 A/G cg06627557 chr7:32535165 LSM5;AVL9 -0.83 -13.08 -0.58 9.21e-32 Cognitive ability; CRC cis rs514406 0.708 rs536621 chr1:53309097 A/G cg08859206 chr1:53392774 SCP2 -0.61 -9.73 -0.47 8.1e-20 Monocyte count; CRC cis rs3820068 0.581 rs16851876 chr1:15950628 A/T cg24675056 chr1:15929824 NA -0.51 -7.21 -0.37 3.8e-12 Systolic blood pressure; CRC cis rs17065868 0.764 rs11552414 chr13:45010867 C/T cg10246903 chr13:45222710 NA 0.56 6.21 0.32 1.64e-9 Antineutrophil cytoplasmic antibody-associated vasculitis; CRC cis rs10504229 0.683 rs79284841 chr8:58107611 T/A cg02725872 chr8:58115012 NA -0.59 -7.96 -0.4 2.85e-14 Developmental language disorder (linguistic errors); CRC cis rs240764 0.658 rs12213201 chr6:101176285 C/A cg09795085 chr6:101329169 ASCC3 -0.42 -5.84 -0.31 1.25e-8 Neuroticism; CRC cis rs67478160 0.619 rs2368560 chr14:104273311 C/T cg01849466 chr14:104193079 ZFYVE21 -0.45 -7.77 -0.39 9.99e-14 Schizophrenia; CRC cis rs1448094 0.935 rs11117119 chr12:86336432 A/T cg19622623 chr12:86230825 RASSF9 -0.36 -5.94 -0.31 7.17e-9 Major depressive disorder; CRC cis rs8105895 0.935 rs10422289 chr19:22256060 C/T cg02657401 chr19:22469223 NA -0.34 -5.65 -0.3 3.56e-8 Body mass index (change over time); CRC cis rs4819052 0.851 rs2838866 chr21:46713014 G/C cg19498844 chr21:46707878 POFUT2;LOC642852 0.75 10.65 0.51 6.14e-23 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC trans rs877282 0.898 rs11253340 chr10:764786 G/T cg22713356 chr15:30763199 NA 1.29 15.31 0.65 2.44e-40 Uric acid levels; CRC cis rs3018066 0.748 rs12642900 chr4:107010329 T/C cg01869342 chr4:106983673 TBCK 0.44 6.7 0.35 9.19e-11 Cancer; CRC cis rs4423214 0.802 rs4402322 chr11:71184015 C/G cg13043300 chr11:71146211 DHCR7 -0.44 -5.98 -0.31 5.98e-9 Vitamin D levels; CRC cis rs875971 0.964 rs778735 chr7:65814809 C/A cg18876405 chr7:65276391 NA 0.52 8.84 0.44 5.97e-17 Aortic root size; CRC cis rs6461049 0.765 rs4719432 chr7:2140330 A/G cg04267008 chr7:1944627 MAD1L1 -0.55 -8.08 -0.41 1.28e-14 Schizophrenia; CRC cis rs1712517 0.873 rs1163086 chr10:105039579 A/G cg05636881 chr10:105038444 INA 0.48 8.31 0.42 2.56e-15 Migraine; CRC cis rs11864453 0.762 rs6416742 chr16:72149061 C/T cg01557791 chr16:72042693 DHODH -0.44 -5.79 -0.3 1.62e-8 Fibrinogen levels; CRC cis rs17270561 0.636 rs1575535 chr6:25809909 C/T cg16482183 chr6:26056742 HIST1H1C 0.71 9.43 0.46 7.49e-19 Iron status biomarkers; CRC cis rs6764363 0.733 rs186704 chr3:295418 T/C cg02057681 chr3:285234 CHL1 -0.35 -5.71 -0.3 2.5e-8 Sudden cardiac arrest; CRC cis rs758324 0.947 rs476428 chr5:131301615 G/A cg06307176 chr5:131281290 NA -0.4 -5.74 -0.3 2.12e-8 Alzheimer's disease in APOE e4- carriers; CRC cis rs11252926 0.574 rs7068976 chr10:453112 A/G cg18196295 chr10:418757 DIP2C 0.48 7.47 0.38 7.46e-13 Psychosis in Alzheimer's disease; CRC cis rs4713118 0.738 rs200465 chr6:27757654 T/A cg25164649 chr6:28176230 NA 0.6 7.94 0.4 3.28e-14 Parkinson's disease; CRC cis rs2836950 0.565 rs2836931 chr21:40546569 T/G cg06238570 chr21:40685208 BRWD1 -0.63 -9.29 -0.46 2.2e-18 Menarche (age at onset); CRC cis rs6500395 0.926 rs11076570 chr16:48597915 G/A cg04672837 chr16:48644449 N4BP1 0.42 5.99 0.31 5.43e-9 Response to tocilizumab in rheumatoid arthritis; CRC trans rs45509595 0.822 rs200484 chr6:27775674 A/G cg06606381 chr12:133084897 FBRSL1 -0.77 -6.6 -0.34 1.66e-10 Breast cancer; CRC cis rs2204008 0.837 rs34381557 chr12:38181983 T/C cg26384229 chr12:38710491 ALG10B 0.69 9.26 0.45 2.81e-18 Bladder cancer; CRC trans rs9409565 0.826 rs9409778 chr9:97242839 G/A cg05679027 chr9:99775184 HIATL2 -0.41 -6.22 -0.32 1.52e-9 Colorectal cancer (alcohol consumption interaction); CRC cis rs1707322 0.721 rs10789471 chr1:46215619 G/A cg06784218 chr1:46089804 CCDC17 0.65 12.05 0.55 5.8e-28 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs7264396 0.943 rs1810742 chr20:34109718 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.42 -6.93 -0.36 2.17e-11 Total cholesterol levels; CRC cis rs926392 0.896 rs742276 chr20:37679849 C/T cg16355469 chr20:37678765 NA 0.35 5.73 0.3 2.28e-8 Dialysis-related mortality; CRC cis rs6838801 0.964 rs4859701 chr4:77564469 T/G cg17476223 chr4:77663285 SHROOM3 -0.41 -5.63 -0.3 3.9e-8 Cleft lip with or without cleft palate; CRC cis rs6461049 0.608 rs3800923 chr7:2184673 A/G cg21782813 chr7:2030301 MAD1L1 0.41 7.37 0.38 1.38e-12 Schizophrenia; CRC cis rs1387259 0.758 rs2634670 chr12:48771877 G/A cg24011408 chr12:48396354 COL2A1 0.44 6.13 0.32 2.5e-9 Obstructive sleep apnea trait (apnea hypopnea index); CRC cis rs4713118 0.527 rs36042294 chr6:27720712 C/G cg21251018 chr6:28226885 NKAPL 0.39 6.08 0.32 3.31e-9 Parkinson's disease; CRC cis rs9463078 0.727 rs2396371 chr6:44946550 C/T cg25276700 chr6:44698697 NA -0.28 -7.13 -0.37 6.58e-12 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; CRC cis rs28655083 0.529 rs589002 chr16:77104044 T/C cg01753188 chr16:77233325 SYCE1L;MON1B 0.46 6.58 0.34 1.87e-10 Lobe attachment (rater-scored or self-reported); CRC cis rs9611519 0.929 rs13055800 chr22:41440424 G/A cg03806693 chr22:41940476 POLR3H -0.59 -7.48 -0.38 6.66e-13 Neuroticism; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg05506986 chr2:174220200 CDCA7 0.41 6.16 0.32 2.11e-9 Intelligence (multi-trait analysis); CRC cis rs10992471 0.603 rs10992342 chr9:95212068 C/T cg14631576 chr9:95140430 CENPP -0.41 -7.33 -0.37 1.77e-12 Visceral adipose tissue/subcutaneous adipose tissue ratio; CRC cis rs9910055 0.529 rs425038 chr17:42182028 T/C cg19774624 chr17:42201019 HDAC5 0.54 7.3 0.37 2.14e-12 Total body bone mineral density; CRC cis rs6973256 0.605 rs7792396 chr7:133345526 T/C cg10665199 chr7:133106180 EXOC4 0.48 7.58 0.39 3.67e-13 Intelligence (multi-trait analysis); CRC cis rs6496667 0.533 rs2589949 chr15:90955015 C/T cg00425431 chr15:90792223 TTLL13 0.32 5.68 0.3 2.91e-8 Rheumatoid arthritis; CRC cis rs798554 0.797 rs798497 chr7:2795957 A/G cg19717773 chr7:2847554 GNA12 -0.47 -6.84 -0.35 3.86e-11 Height; CRC cis rs2013441 0.670 rs35317166 chr17:19959820 T/A cg13482628 chr17:19912719 NA 0.41 5.71 0.3 2.5e-8 Obesity-related traits; CRC cis rs367943 1.000 rs348928 chr5:112815295 C/T cg12552261 chr5:112820674 MCC -0.49 -7.66 -0.39 2.06e-13 Type 2 diabetes; CRC cis rs7811142 0.830 rs7792525 chr7:99972122 A/G cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.1 15.83 0.66 2.27e-42 Platelet count; CRC cis rs9399135 0.967 rs6909975 chr6:135315570 C/T cg22676075 chr6:135203613 NA 0.42 6.33 0.33 8.1e-10 Red blood cell count; CRC cis rs6860806 0.507 rs200837 chr5:131699958 G/A cg09877947 chr5:131593287 PDLIM4 0.43 7.01 0.36 1.39e-11 Breast cancer; CRC cis rs2228479 0.850 rs2238532 chr16:89863672 T/C cg04013166 chr16:89971882 TCF25 0.62 5.64 0.3 3.59e-8 Skin colour saturation; CRC cis rs4727027 0.899 rs4727025 chr7:148862863 A/G cg23583168 chr7:148888333 NA -0.92 -16.26 -0.67 4.73e-44 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC cis rs72615157 0.595 rs112241539 chr7:99847237 C/T cg19337854 chr7:99768885 GPC2 0.47 5.93 0.31 7.64e-9 Lung function (FEV1/FVC); CRC cis rs9549328 0.700 rs3011474 chr13:113617865 T/C cg25790453 chr13:113633590 MCF2L 0.44 7.56 0.38 4e-13 Systolic blood pressure; CRC cis rs6582630 0.519 rs11514056 chr12:38284001 G/T cg26384229 chr12:38710491 ALG10B 0.66 9.19 0.45 4.44e-18 Drug-induced liver injury (flucloxacillin); CRC trans rs7395662 1.000 rs7482528 chr11:48640052 A/G cg21153622 chr11:89784906 NA -0.47 -7.41 -0.38 1.08e-12 HDL cholesterol; CRC cis rs10540 1.000 rs116876680 chr11:517473 G/T cg03352830 chr11:487213 PTDSS2 0.65 7.41 0.38 1.09e-12 Body mass index; CRC cis rs832540 0.512 rs33320 chr5:56206529 C/T cg24531977 chr5:56204891 C5orf35 -0.56 -8.54 -0.43 4.93e-16 Coronary artery disease; CRC cis rs4819052 0.851 rs2838865 chr21:46712299 C/T cg11663144 chr21:46675770 NA -0.84 -14.25 -0.62 3.27e-36 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs2404602 0.532 rs12591100 chr15:76700801 C/A cg23625390 chr15:77176239 SCAPER -0.6 -8.98 -0.44 2.09e-17 Blood metabolite levels; CRC cis rs561341 0.769 rs559228 chr17:30294527 T/C cg19193384 chr17:30244184 NA -0.65 -7.48 -0.38 6.75e-13 Hip circumference adjusted for BMI; CRC cis rs950169 0.959 rs66801143 chr15:84736657 C/T cg03959625 chr15:84868606 LOC388152 0.41 6.08 0.32 3.26e-9 Schizophrenia; CRC cis rs10504229 0.683 rs56408763 chr8:58137276 G/A cg04204079 chr8:58130323 NA -0.45 -5.78 -0.3 1.71e-8 Developmental language disorder (linguistic errors); CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg05313302 chr10:75006908 DNAJC9 0.44 6.15 0.32 2.3e-9 Anxiety disorder; CRC cis rs6502050 0.871 rs6416857 chr17:80063004 A/G cg19223190 chr17:80058835 NA -0.45 -7.24 -0.37 3.21e-12 Life satisfaction; CRC cis rs9549328 0.614 rs35299896 chr13:113617229 G/T cg17524180 chr13:113633600 MCF2L 0.52 9.51 0.46 4.24e-19 Systolic blood pressure; CRC cis rs10971721 0.749 rs72725371 chr9:33825011 G/A cg13495928 chr9:33750294 PRSS3 0.55 5.93 0.31 7.79e-9 Body mass index; CRC trans rs6076960 0.684 rs6054055 chr20:6257517 C/G cg24759859 chr6:86352639 SYNCRIP 0.47 6.5 0.34 3.01e-10 Smooth-surface caries; CRC trans rs8002861 0.905 rs12428350 chr13:44446161 G/A cg12856521 chr11:46389249 DGKZ -0.41 -6.46 -0.34 3.69e-10 Leprosy; CRC cis rs8063761 0.689 rs4785763 chr16:90066936 G/T cg08547343 chr16:90038815 CENPBD1;AFG3L1 -0.47 -6.43 -0.33 4.6e-10 Squamous cell carcinoma; CRC trans rs2727020 0.823 rs7102374 chr11:49261795 G/A cg03929089 chr4:120376271 NA 0.65 8.89 0.44 3.98e-17 Coronary artery disease; CRC cis rs11677416 0.813 rs4848299 chr2:113523454 C/A cg06156847 chr2:113672199 IL1F7 -0.4 -6.03 -0.32 4.38e-9 Response to antipsychotic treatment in schizophrenia (working memory); CRC cis rs9894429 0.789 rs35887231 chr17:79587126 G/A cg18240062 chr17:79603768 NPLOC4 0.67 11.91 0.55 2.01e-27 Eye color traits; CRC cis rs6662572 0.737 rs6665193 chr1:46347910 G/A cg03123370 chr1:45965343 CCDC163P;MMACHC -0.46 -5.9 -0.31 8.93e-9 Blood protein levels; CRC cis rs896854 0.738 rs527234 chr8:95963798 C/G cg16049864 chr8:95962084 TP53INP1 0.55 8.94 0.44 2.94e-17 Type 2 diabetes; CRC cis rs7618915 0.524 rs10433615 chr3:52638482 C/T cg07507251 chr3:52567010 NT5DC2 0.42 5.98 0.31 5.82e-9 Bipolar disorder; CRC cis rs7107174 1.000 rs10899485 chr11:78072383 C/T cg02023728 chr11:77925099 USP35 -0.45 -8.03 -0.4 1.8e-14 Testicular germ cell tumor; CRC cis rs4363385 0.818 rs436621 chr1:153005492 A/G cg25856811 chr1:152973957 SPRR3 -0.25 -6.99 -0.36 1.51e-11 Inflammatory skin disease; CRC cis rs6445967 1.000 rs13059916 chr3:58316364 A/G cg23715586 chr3:58305044 RPP14 0.36 5.99 0.31 5.44e-9 Platelet count; CRC cis rs7374004 1.000 rs7374004 chr3:38625709 A/T cg01465620 chr3:38496096 LOC100128640;ACVR2B -0.42 -5.74 -0.3 2.1e-8 PR interval; CRC cis rs4700695 0.925 rs4700693 chr5:65399078 A/G cg21114390 chr5:65439923 SFRS12 -0.63 -6.92 -0.36 2.31e-11 Facial morphology (factor 19); CRC cis rs3617 0.625 rs3774364 chr3:52863605 G/A cg15147215 chr3:52552868 STAB1 -0.48 -7.8 -0.39 8.38e-14 Red blood cell count;Autism spectrum disorder or schizophrenia; CRC cis rs919433 0.963 rs13033821 chr2:198173536 T/G cg10820045 chr2:198174542 NA -0.54 -9.16 -0.45 5.5e-18 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC cis rs10504229 1.000 rs72650900 chr8:58185675 T/A cg02290350 chr8:58132656 NA -0.42 -5.96 -0.31 6.62e-9 Developmental language disorder (linguistic errors); CRC cis rs875971 1.000 rs1167411 chr7:65539264 C/G cg00343986 chr7:65444356 GUSB -0.47 -6.83 -0.35 4.15e-11 Aortic root size; CRC cis rs457287 0.772 rs465032 chr9:4833866 T/C cg14182974 chr9:4791918 RCL1 0.42 5.9 0.31 8.81e-9 Platelet count; CRC cis rs4253772 0.550 rs6007830 chr22:46711323 C/T cg09491104 chr22:46646882 C22orf40 -0.43 -5.85 -0.31 1.2e-8 LDL cholesterol;Cholesterol, total; CRC cis rs67478160 0.643 rs2295145 chr14:104202304 G/A cg01849466 chr14:104193079 ZFYVE21 -0.48 -8.43 -0.42 1.1e-15 Schizophrenia; CRC cis rs2276314 0.857 rs6507157 chr18:33631703 A/C cg19628046 chr18:33552617 C18orf21 0.57 7.62 0.39 2.75e-13 Endometriosis;Drug-induced torsades de pointes; CRC cis rs4604732 0.574 rs111928142 chr1:247625229 G/T cg12758973 chr1:247694275 LOC148824;OR2C3 0.42 6.0 0.31 5.32e-9 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CRC cis rs1784581 0.802 rs9458430 chr6:162426517 G/T cg17173639 chr6:162384350 PARK2 -0.57 -8.69 -0.43 1.74e-16 Itch intensity from mosquito bite; CRC cis rs67311347 1.000 rs13324109 chr3:40460767 T/C cg09455208 chr3:40491958 NA 0.45 9.25 0.45 2.89e-18 Renal cell carcinoma; CRC cis rs2836974 0.674 rs1011413 chr21:40638241 A/G cg06238570 chr21:40685208 BRWD1 -0.8 -12.96 -0.58 2.47e-31 Cognitive function; CRC cis rs735396 1.000 rs1169310 chr12:121439433 G/A cg02403541 chr12:121454288 C12orf43 0.45 6.72 0.35 7.97e-11 N-glycan levels; CRC cis rs7605827 0.866 rs9710962 chr2:15533884 C/A cg19274914 chr2:15703543 NA 0.39 5.88 0.31 9.87e-9 Educational attainment (years of education); CRC cis rs76419734 0.558 rs10030620 chr4:106574536 A/G cg05309399 chr4:106552544 FLJ20184 -0.55 -6.43 -0.33 4.54e-10 Post bronchodilator FEV1; CRC cis rs453301 0.686 rs28665409 chr8:8869277 G/A cg06636001 chr8:8085503 FLJ10661 -0.48 -7.01 -0.36 1.32e-11 Joint mobility (Beighton score); CRC cis rs28719689 0.655 rs17063833 chr8:1275384 A/G cg22761795 chr8:1265118 NA 0.57 6.92 0.36 2.33e-11 Colonoscopy-negative controls vs population controls; CRC cis rs10504229 1.000 rs67236942 chr8:58176525 T/C cg02290350 chr8:58132656 NA -0.42 -5.96 -0.31 6.62e-9 Developmental language disorder (linguistic errors); CRC cis rs1348850 0.914 rs4893944 chr2:178289357 G/T cg02961200 chr2:178257176 LOC100130691;AGPS 0.58 8.61 0.43 3.16e-16 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs12188164 0.543 rs890972 chr5:462465 C/A cg21625146 chr5:486483 SLC9A3 0.37 5.75 0.3 2.06e-8 Cystic fibrosis severity; CRC cis rs9462027 0.628 rs10738078 chr6:34693917 G/A cg07306190 chr6:34760872 UHRF1BP1 0.34 6.07 0.32 3.49e-9 Systemic lupus erythematosus; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg27498211 chr16:4588826 C16orf5 0.31 6.24 0.33 1.35e-9 Liver disease severity in Alagille syndrome; CRC cis rs13108904 0.870 rs4493483 chr4:1279916 G/A cg00684032 chr4:1343700 KIAA1530 0.48 7.08 0.36 8.57e-12 Obesity-related traits; CRC cis rs7945718 0.621 rs7943920 chr11:12695614 A/G cg25843174 chr11:12811716 TEAD1 0.4 7.11 0.37 7.06e-12 Educational attainment (years of education); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg18382590 chr9:131219195 ODF2 0.48 6.86 0.35 3.43e-11 Response to antipsychotic treatment; CRC cis rs7617773 0.780 rs2541 chr3:48339618 A/G cg11946769 chr3:48343235 NME6 0.73 9.93 0.48 1.73e-20 Coronary artery disease; CRC trans rs7267979 1.000 rs2500424 chr20:25391969 C/T cg17903999 chr18:56338584 MALT1 0.4 6.51 0.34 2.76e-10 Liver enzyme levels (alkaline phosphatase); CRC cis rs131777 0.577 rs131748 chr22:51024837 A/G cg00083937 chr22:51039805 MAPK8IP2 -0.35 -5.72 -0.3 2.41e-8 Mean corpuscular volume;Mean corpuscular hemoglobin; CRC cis rs17125944 0.505 rs75296244 chr14:53233218 G/A cg00686598 chr14:53173677 PSMC6 1.23 11.56 0.54 3.66e-26 Alzheimer's disease (late onset); CRC cis rs2032447 0.802 rs198853 chr6:26104096 T/C cg18357526 chr6:26021779 HIST1H4A -0.76 -11.44 -0.53 9.94e-26 Intelligence (multi-trait analysis); CRC cis rs4561483 0.801 rs33649 chr16:11979608 G/C cg08843971 chr16:11963173 GSPT1 -0.62 -9.57 -0.47 2.66e-19 Testicular germ cell tumor; CRC trans rs459571 0.920 rs455073 chr9:136909141 G/C cg15028160 chr19:49622717 PPFIA3;C19orf73 -0.5 -6.02 -0.31 4.54e-9 Platelet distribution width; CRC cis rs4665809 1.000 rs10202478 chr2:26276049 T/C cg27170947 chr2:26402098 FAM59B -0.46 -6.1 -0.32 2.96e-9 Gut microbiome composition (summer); CRC cis rs1451375 0.617 rs10277662 chr7:50594836 C/T cg14593290 chr7:50529359 DDC 0.62 8.15 0.41 7.72e-15 Malaria; CRC cis rs1448094 0.556 rs11610789 chr12:86169541 A/G cg06740227 chr12:86229804 RASSF9 0.39 5.86 0.31 1.09e-8 Major depressive disorder; CRC cis rs763121 0.853 rs1043441 chr22:39130964 C/T cg06022373 chr22:39101656 GTPBP1 0.78 12.28 0.56 8.75e-29 Menopause (age at onset); CRC cis rs10911232 0.507 rs4575047 chr1:182976028 A/G ch.1.3577855R chr1:183094577 LAMC1 0.87 15.17 0.64 9.22e-40 Hypertriglyceridemia; CRC cis rs4566357 0.615 rs2272200 chr2:227912331 G/A cg11843606 chr2:227700838 RHBDD1 -0.44 -6.85 -0.35 3.53e-11 Coronary artery disease; CRC cis rs3790844 0.678 rs3790854 chr1:200000125 C/T cg13229857 chr1:200006247 NR5A2 -0.51 -7.45 -0.38 8.04e-13 Pancreatic cancer; CRC cis rs6860806 0.507 rs2631372 chr5:131703578 C/G cg12564285 chr5:131593104 PDLIM4 0.46 7.78 0.39 9.36e-14 Breast cancer; CRC cis rs929354 0.742 rs6956046 chr7:156962874 G/A cg05182265 chr7:156933206 UBE3C -0.76 -14.38 -0.62 1.04e-36 Body mass index; CRC cis rs3796352 0.667 rs34288509 chr3:52849493 G/C cg06204229 chr3:52865917 ITIH4 0.6 7.3 0.37 2.22e-12 Immune reponse to smallpox (secreted IL-2); CRC cis rs3749237 0.964 rs34522271 chr3:49808517 A/G cg05072774 chr3:49840536 C3orf54 -0.43 -5.74 -0.3 2.15e-8 Resting heart rate; CRC cis rs7615952 0.641 rs61048217 chr3:125807905 G/T cg15145296 chr3:125709740 NA -0.57 -6.72 -0.35 8.16e-11 Blood pressure (smoking interaction); CRC trans rs13315871 0.615 rs7625655 chr3:58337723 C/T cg25250853 chr2:85822726 RNF181 -0.53 -6.35 -0.33 7.08e-10 Cholesterol, total; CRC cis rs4900538 0.821 rs8016191 chr14:102825340 G/A cg01761236 chr14:102990251 NA -0.29 -5.77 -0.3 1.86e-8 Mean corpuscular volume;Mean corpuscular hemoglobin; CRC cis rs17092148 0.836 rs4322911 chr20:33182577 G/A cg08999081 chr20:33150536 PIGU 0.49 6.35 0.33 7.34e-10 Neuroticism; CRC cis rs7043114 0.525 rs2516567 chr9:95187418 C/T cg13798575 chr9:95087839 CENPP;NOL8 -0.4 -5.96 -0.31 6.43e-9 Height; CRC cis rs6951245 0.872 rs113119264 chr7:1080564 G/A cg26224354 chr7:1096374 C7orf50;GPR146 -0.89 -11.19 -0.53 7.61e-25 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs6496667 0.738 rs5020807 chr15:91043188 C/A cg04176472 chr15:90893244 GABARAPL3 0.54 7.76 0.39 1.08e-13 Rheumatoid arthritis; CRC cis rs1538970 0.924 rs2088100 chr1:45877575 C/T cg05343316 chr1:45956843 TESK2 0.72 9.7 0.47 1.02e-19 Platelet count; CRC cis rs11785693 0.862 rs11781233 chr8:4993653 C/G cg26367366 chr8:4980734 NA -0.79 -9.97 -0.48 1.27e-20 Neuroticism (multi-trait analysis);Neuroticism; CRC cis rs2839186 0.721 rs3788252 chr21:47661235 C/T cg11766577 chr21:47581405 C21orf56 -0.51 -8.36 -0.42 1.75e-15 Testicular germ cell tumor; CRC cis rs12451471 0.500 rs8077056 chr17:78076006 C/T cg12326244 chr17:78078995 GAA -0.38 -5.71 -0.3 2.46e-8 Plateletcrit;Mean corpuscular hemoglobin concentration; CRC cis rs4718428 0.672 rs4718412 chr7:66286867 C/T cg18252515 chr7:66147081 NA 0.46 6.38 0.33 5.86e-10 Corneal structure; CRC cis rs3736485 0.932 rs2278988 chr15:51915234 A/C cg08986416 chr15:51914746 DMXL2 -0.45 -6.39 -0.33 5.63e-10 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs9309711 0.736 rs13409102 chr2:3496321 G/A cg10845886 chr2:3471009 TTC15 -0.64 -9.53 -0.47 3.63e-19 Neurofibrillary tangles; CRC trans rs10411161 0.690 rs7252336 chr19:52389514 C/T cg22319618 chr22:45562946 NUP50 -0.65 -7.24 -0.37 3.26e-12 Breast cancer; CRC cis rs17270561 0.609 rs1317510 chr6:25778924 T/C cg17691542 chr6:26056736 HIST1H1C 0.68 8.59 0.43 3.51e-16 Iron status biomarkers; CRC cis rs4561483 0.603 rs17235629 chr16:11932421 C/T cg08843971 chr16:11963173 GSPT1 -0.49 -7.39 -0.38 1.21e-12 Testicular germ cell tumor; CRC cis rs801193 0.660 rs2659914 chr7:66156914 C/T cg18912574 chr7:65842487 NCRNA00174 0.36 5.99 0.31 5.46e-9 Aortic root size; CRC cis rs4862750 0.872 rs13101408 chr4:187894777 G/A cg11301795 chr4:187892539 NA -0.87 -19.9 -0.74 2.15e-58 Lobe attachment (rater-scored or self-reported); CRC cis rs9916302 0.851 rs4794810 chr17:37603774 T/C cg07936489 chr17:37558343 FBXL20 -0.76 -11.31 -0.53 2.72e-25 Glomerular filtration rate (creatinine); CRC cis rs2456568 0.709 rs7942444 chr11:93637160 G/A cg26875233 chr11:93583750 C11orf90 0.31 5.83 0.31 1.32e-8 Response to serotonin reuptake inhibitors in major depressive disorder; CRC cis rs10924970 0.687 rs946027 chr1:235346286 T/C cg09010748 chr1:235293032 TOMM20 -0.41 -5.74 -0.3 2.12e-8 Asthma; CRC cis rs9517320 0.534 rs9556963 chr13:99157026 G/A cg07423050 chr13:99094983 FARP1 -0.57 -8.08 -0.41 1.23e-14 Longevity; CRC cis rs7937682 0.924 rs4630327 chr11:111539327 C/T cg09085632 chr11:111637200 PPP2R1B 0.98 20.69 0.75 1.72e-61 Primary sclerosing cholangitis; CRC cis rs10504229 0.906 rs113823909 chr8:58170635 A/G cg02725872 chr8:58115012 NA -0.38 -6.32 -0.33 8.27e-10 Developmental language disorder (linguistic errors); CRC cis rs6724607 1.000 rs11680758 chr2:191446268 T/G cg21644426 chr2:191273491 MFSD6 0.45 6.16 0.32 2.09e-9 Pulse pressure; CRC cis rs7020830 0.825 rs10973248 chr9:37197768 C/T cg14294708 chr9:37120828 ZCCHC7 1.19 27.17 0.83 4.38e-86 Schizophrenia; CRC cis rs6582630 0.599 rs4882313 chr12:38454011 G/A cg13010199 chr12:38710504 ALG10B -0.42 -5.96 -0.31 6.39e-9 Drug-induced liver injury (flucloxacillin); CRC cis rs10484885 0.588 rs9344947 chr6:90304789 A/G cg13799429 chr6:90582589 CASP8AP2 0.57 7.54 0.38 4.71e-13 QRS interval (sulfonylurea treatment interaction); CRC cis rs1552244 1.000 rs2272125 chr3:10138069 A/C cg10729496 chr3:10149963 C3orf24 0.49 6.71 0.35 8.51e-11 Alzheimer's disease; CRC cis rs736408 0.608 rs6445534 chr3:52743384 G/A cg15147215 chr3:52552868 STAB1 -0.62 -10.45 -0.5 2.81e-22 Bipolar disorder; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg13692869 chr1:169336982 NME7;BLZF1 0.56 7.49 0.38 6.44e-13 Thyroid stimulating hormone; CRC cis rs6598955 0.671 rs10902732 chr1:26606174 A/C cg04990556 chr1:26633338 UBXN11 0.53 5.73 0.3 2.23e-8 Obesity-related traits; CRC cis rs6570726 0.791 rs6913727 chr6:145899826 A/G cg05347473 chr6:146136440 FBXO30 0.38 5.86 0.31 1.15e-8 Lobe attachment (rater-scored or self-reported); CRC cis rs921968 0.541 rs576901 chr2:219424364 A/G cg02176678 chr2:219576539 TTLL4 0.53 8.49 0.42 7.06e-16 Mean corpuscular hemoglobin concentration; CRC cis rs4665809 0.590 rs1865324 chr2:26417533 C/A cg26119090 chr2:26468346 HADHA;HADHB -1.05 -15.29 -0.64 3.04e-40 Gut microbiome composition (summer); CRC trans rs4853036 0.672 rs35293234 chr2:70025165 C/A cg14633329 chr9:139640053 LCN6 -0.34 -5.98 -0.31 5.69e-9 Colorectal or endometrial cancer; CRC cis rs7666738 0.800 rs28427190 chr4:98989106 A/G cg17366294 chr4:99064904 C4orf37 0.44 7.39 0.38 1.23e-12 Colonoscopy-negative controls vs population controls; CRC cis rs12497850 0.931 rs4974085 chr3:48924900 C/T cg07636037 chr3:49044803 WDR6 1.03 17.99 0.7 7.33e-51 Parkinson's disease; CRC cis rs1832871 0.672 rs56115227 chr6:158773884 G/A cg07165851 chr6:158734300 TULP4 0.61 7.76 0.39 1.11e-13 Height; CRC cis rs2075671 0.903 rs11979818 chr7:100293639 A/G cg00334542 chr7:100209784 MOSPD3 0.54 6.72 0.35 7.8e-11 Other erythrocyte phenotypes; CRC trans rs7615952 0.932 rs3811679 chr3:125648283 A/G cg07211511 chr3:129823064 LOC729375 -1.06 -17.63 -0.7 1.99e-49 Blood pressure (smoking interaction); CRC cis rs11203032 0.831 rs4617498 chr10:90943713 G/A cg16672925 chr10:90967113 CH25H 0.44 5.67 0.3 3.13e-8 Heart failure; CRC cis rs644799 0.965 rs549695 chr11:95617788 T/C cg25622487 chr11:95524042 FAM76B;CEP57 0.74 11.29 0.53 3.24e-25 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs9837602 1.000 rs62285478 chr3:99822135 C/T cg07805332 chr3:99536008 MIR548G;C3orf26 -0.46 -6.09 -0.32 3.18e-9 Breast cancer; CRC cis rs12540874 0.518 rs12718674 chr7:50627130 T/C cg14593290 chr7:50529359 DDC -0.45 -6.24 -0.33 1.31e-9 Systemic sclerosis; CRC cis rs449789 0.817 rs1875814 chr6:159720266 G/A cg14500486 chr6:159655392 FNDC1 -0.48 -7.39 -0.38 1.24e-12 Pulse pressure; CRC cis rs11170631 0.504 rs10128880 chr12:53927783 T/C cg06632207 chr12:54070931 ATP5G2 0.45 7.58 0.39 3.62e-13 Height; CRC cis rs651907 0.535 rs11711903 chr3:101500748 C/G cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.58 7.73 0.39 1.32e-13 Colorectal cancer; CRC cis rs6089584 0.927 rs3787427 chr20:60579789 T/C cg13770153 chr20:60521292 NA -0.55 -9.14 -0.45 6.38e-18 Body mass index; CRC cis rs344364 0.511 rs1742469 chr16:1950244 C/T cg14074117 chr16:1909714 C16orf73 0.41 5.66 0.3 3.28e-8 Glomerular filtration rate in chronic kidney disease; CRC cis rs7192750 0.617 rs9929256 chr16:72040032 A/C cg14768367 chr16:72042858 DHODH 0.83 7.35 0.38 1.62e-12 LDL cholesterol levels;Total cholesterol levels; CRC cis rs7246657 0.943 rs1382357 chr19:37977609 G/A cg23950597 chr19:37808831 NA -0.48 -5.89 -0.31 9.5e-9 Coronary artery calcification; CRC cis rs9814567 1.000 rs9989967 chr3:134238964 A/C cg06541857 chr3:134203789 ANAPC13;CEP63 -0.38 -5.64 -0.3 3.64e-8 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs11764590 0.715 rs11766468 chr7:2082604 G/A cg25834613 chr7:1915315 MAD1L1 -0.46 -6.59 -0.34 1.72e-10 Neuroticism; CRC cis rs13064411 0.696 rs35860985 chr3:113209828 C/T cg18753928 chr3:113234510 CCDC52 -0.7 -10.83 -0.51 1.45e-23 Response to simvastatin treatment (PCSK9 protein level change); CRC cis rs1355223 0.545 rs7123029 chr11:34874815 G/A cg11058730 chr11:34937778 PDHX;APIP -0.43 -6.07 -0.32 3.51e-9 Systemic lupus erythematosus and Systemic sclerosis; CRC cis rs2839186 0.771 rs2839155 chr21:47639992 A/G cg11766577 chr21:47581405 C21orf56 -0.51 -8.28 -0.42 3.14e-15 Testicular germ cell tumor; CRC cis rs9462846 0.959 rs9462845 chr6:42860958 A/G cg21280719 chr6:42927975 GNMT -0.33 -5.86 -0.31 1.11e-8 Blood protein levels; CRC cis rs939658 0.805 rs35291410 chr15:79438660 C/T cg17916960 chr15:79447300 NA -0.44 -7.26 -0.37 2.75e-12 Refractive error; CRC cis rs9486719 0.843 rs2499793 chr6:96846402 A/C cg06623918 chr6:96969491 KIAA0776 0.79 8.57 0.43 4.23e-16 Migraine;Coronary artery disease; CRC cis rs17127169 0.536 rs112625995 chr1:65496627 A/G cg15583014 chr1:65468659 NA 0.89 6.12 0.32 2.71e-9 Sitting height ratio; CRC cis rs6662572 0.737 rs4474301 chr1:46255272 A/G cg08644498 chr1:46502608 NA -0.43 -6.89 -0.36 2.8e-11 Blood protein levels; CRC cis rs9910055 0.762 rs4239142 chr17:42205876 A/G cg09913183 chr17:42254507 C17orf65;ASB16 -0.57 -8.29 -0.42 2.85e-15 Total body bone mineral density; CRC cis rs7524258 0.900 rs2412151 chr1:7303216 G/C cg07173049 chr1:7289937 CAMTA1 0.51 8.46 0.42 8.88e-16 Tourette's syndrome or obsessive-compulsive disorder; CRC cis rs57994353 0.793 rs35531907 chr9:139327143 C/T cg13611204 chr9:139324423 INPP5E -0.42 -5.9 -0.31 8.84e-9 Eosinophil counts;Cutaneous squamous cell carcinoma; CRC cis rs763121 0.853 rs5750671 chr22:39094619 A/C cg06022373 chr22:39101656 GTPBP1 0.81 13.33 0.59 1.05e-32 Menopause (age at onset); CRC cis rs77972916 0.561 rs4372955 chr2:43566146 A/G cg06169590 chr2:43455088 ZFP36L2;LOC100129726 -0.54 -5.66 -0.3 3.26e-8 Granulocyte percentage of myeloid white cells; CRC cis rs7044106 0.762 rs3904197 chr9:123480378 C/T cg14255062 chr9:123606675 PSMD5;LOC253039 0.48 7.42 0.38 9.88e-13 Hip circumference adjusted for BMI; CRC cis rs12477438 0.798 rs6705583 chr2:99602625 T/C cg14399236 chr2:99771627 LIPT1;TSGA10 -0.75 -10.57 -0.5 1.08e-22 Chronic sinus infection; CRC cis rs1005224 0.819 rs10147492 chr14:76155309 T/G cg25116370 chr14:76127843 TTLL5;C14orf1 -0.46 -7.17 -0.37 4.92e-12 Large artery stroke; CRC cis rs2011503 0.941 rs56278919 chr19:19367190 A/G cg11584989 chr19:19387371 SF4 0.59 6.72 0.35 7.95e-11 Bipolar disorder; CRC cis rs4561483 0.801 rs33620 chr16:12008546 C/G cg08843971 chr16:11963173 GSPT1 -0.63 -9.82 -0.48 3.98e-20 Testicular germ cell tumor; CRC cis rs8060686 0.920 rs2292316 chr16:67861134 C/G cg08314208 chr16:67682810 RLTPR 0.63 7.21 0.37 3.95e-12 HDL cholesterol;Metabolic syndrome; CRC cis rs66486766 1 rs66486766 chr15:84806060 G/A cg11189052 chr15:85197271 WDR73 0.63 8.87 0.44 4.87e-17 Bipolar disorder lithium response (categorical) or schizophrenia; CRC cis rs4713118 0.513 rs149951 chr6:28033087 T/C cg02683197 chr6:28174875 NA 0.62 8.5 0.42 6.91e-16 Parkinson's disease; CRC cis rs12451471 0.637 rs12950757 chr17:78096800 T/G cg12100956 chr17:78086420 GAA -0.37 -5.73 -0.3 2.22e-8 Plateletcrit;Mean corpuscular hemoglobin concentration; CRC cis rs10504229 0.683 rs72650849 chr8:58140323 A/G cg24829409 chr8:58192753 C8orf71 -0.55 -8.03 -0.4 1.71e-14 Developmental language disorder (linguistic errors); CRC cis rs11864453 0.826 rs12325142 chr16:72138112 G/T cg01557791 chr16:72042693 DHODH -0.47 -6.59 -0.34 1.76e-10 Fibrinogen levels; CRC cis rs2836974 0.897 rs35386515 chr21:40532047 C/T cg06238570 chr21:40685208 BRWD1 0.74 10.4 0.5 4.41e-22 Cognitive function; CRC cis rs68170813 0.599 rs11769901 chr7:106958505 G/A cg02696742 chr7:106810147 HBP1 -0.59 -6.54 -0.34 2.29e-10 Coronary artery disease; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg12588638 chr12:83080208 TMTC2 0.44 6.41 0.33 5.15e-10 Response to antipsychotic treatment; CRC cis rs9368481 0.502 rs3933232 chr6:26877446 T/C cg12292205 chr6:26970375 C6orf41 0.62 9.82 0.48 4e-20 Autism spectrum disorder or schizophrenia; CRC cis rs780096 0.526 rs3845686 chr2:27655447 T/G cg12648201 chr2:27665141 KRTCAP3 -0.33 -6.3 -0.33 9.69e-10 Total body bone mineral density; CRC cis rs10791323 0.628 rs1893850 chr11:133705356 T/C cg06766960 chr11:133703094 NA -0.36 -6.1 -0.32 2.92e-9 Childhood ear infection; CRC trans rs2303319 0.504 rs56026147 chr2:162614089 T/C cg18122310 chr12:50236657 BCDIN3D -0.73 -6.35 -0.33 7.23e-10 Cognitive function; CRC cis rs561341 0.941 rs72825736 chr17:30330286 G/A cg23018236 chr17:30244563 NA -0.67 -8.01 -0.4 1.96e-14 Hip circumference adjusted for BMI; CRC cis rs6502050 0.835 rs6502067 chr17:80111205 A/G cg19223190 chr17:80058835 NA 0.4 6.36 0.33 6.88e-10 Life satisfaction; CRC cis rs853679 0.546 rs200989 chr6:27816442 A/G cg19041857 chr6:27730383 NA -0.71 -6.67 -0.35 1.05e-10 Depression; CRC cis rs2832191 0.716 rs8132085 chr21:30501389 G/T cg08807101 chr21:30365312 RNF160 -0.69 -10.72 -0.51 3.49e-23 Dental caries; CRC cis rs6912958 0.500 rs3828759 chr6:87806640 T/C cg08069147 chr6:88032118 GJB7;C6orf162 -0.62 -8.98 -0.44 2.14e-17 Monocyte percentage of white cells; CRC cis rs6502050 0.835 rs8065037 chr17:80158966 T/G cg19223190 chr17:80058835 NA 0.4 6.52 0.34 2.63e-10 Life satisfaction; CRC cis rs6952808 0.792 rs35582663 chr7:1948756 G/A cg04267008 chr7:1944627 MAD1L1 -0.84 -12.35 -0.56 4.69e-29 Bipolar disorder and schizophrenia; CRC cis rs3812049 0.784 rs2617617 chr5:127455008 C/T cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.72 8.71 0.43 1.49e-16 Lymphocyte counts;Red cell distribution width; CRC cis rs4969178 0.932 rs3744219 chr17:76400236 G/A cg05887092 chr17:76393375 PGS1 0.56 10.01 0.48 9.4e-21 HDL cholesterol levels; CRC cis rs8060686 0.920 rs2271293 chr16:67902070 A/G cg08314208 chr16:67682810 RLTPR 0.61 6.64 0.34 1.3e-10 HDL cholesterol;Metabolic syndrome; CRC cis rs9826463 0.702 rs28365824 chr3:142315114 C/A cg20824294 chr3:142316082 PLS1 0.42 6.84 0.35 3.86e-11 QRS duration in Tripanosoma cruzi seropositivity; CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg26751469 chr19:56116382 NA -0.5 -6.23 -0.32 1.45e-9 Diisocyanate-induced asthma; CRC cis rs2032447 0.702 rs199753 chr6:26001888 G/A cg18357526 chr6:26021779 HIST1H4A 0.8 12.03 0.55 6.84e-28 Intelligence (multi-trait analysis); CRC cis rs516243 0.806 rs7545228 chr1:10740303 G/C cg02903756 chr1:10750680 CASZ1 -0.42 -7.18 -0.37 4.57e-12 Migraine - clinic-based; CRC cis rs1559088 0.600 rs7259117 chr19:33550113 G/T cg17764715 chr19:33622953 WDR88 0.43 6.23 0.32 1.47e-9 Bone ultrasound measurement (broadband ultrasound attenuation); CRC cis rs7811142 0.830 rs73401443 chr7:99977582 T/G cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.03 14.54 0.63 2.38e-37 Platelet count; CRC cis rs4925540 0.724 rs3104110 chr1:247173006 A/G cg22502715 chr1:247171572 ZNF695 0.42 6.02 0.31 4.71e-9 Response to taxane treatment (docetaxel); CRC cis rs7474896 0.583 rs10740950 chr10:38003496 C/T cg25427524 chr10:38739819 LOC399744 -0.6 -7.58 -0.39 3.58e-13 Obesity (extreme); CRC cis rs9443189 0.570 rs569731 chr6:76357593 G/A cg01950844 chr6:76311363 SENP6 0.73 9.76 0.47 6.14e-20 Prostate cancer; CRC cis rs10191773 0.535 rs11123133 chr2:112965023 G/A cg24977338 chr2:113188963 RGPD8;RGPD5 -0.65 -5.89 -0.31 9.39e-9 Yeast infection; CRC cis rs2386661 0.522 rs11258044 chr10:5644392 C/T cg26603656 chr10:5671107 NA 0.37 6.6 0.34 1.64e-10 Breast cancer; CRC cis rs6912958 0.712 rs4707383 chr6:88330602 T/A cg12350822 chr6:88032061 C6orf162;GJB7 -0.32 -6.01 -0.31 5e-9 Monocyte percentage of white cells; CRC cis rs3087591 0.690 rs12103621 chr17:29607235 T/A cg24425628 chr17:29625626 OMG;NF1 -0.82 -14.37 -0.62 1.11e-36 Hip circumference; CRC cis rs9311474 0.508 rs4687546 chr3:52605943 T/A cg10802521 chr3:52805072 NEK4 -0.56 -8.89 -0.44 4e-17 Electroencephalogram traits; CRC cis rs1707322 1.000 rs12097799 chr1:46459886 C/A cg03146154 chr1:46216737 IPP 0.51 7.16 0.37 5.18e-12 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC trans rs6089829 1.000 rs6089829 chr20:61669036 C/T cg23505145 chr19:12996616 KLF1 -0.48 -7.77 -0.39 1.03e-13 Prostate cancer (SNP x SNP interaction); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg26672739 chr14:77843588 C14orf174;TMED8 0.38 6.09 0.32 3.11e-9 Liver disease severity in Alagille syndrome; CRC cis rs67478160 0.595 rs12889993 chr14:104274294 A/G cg08213375 chr14:104286397 PPP1R13B 0.62 12.96 0.58 2.67e-31 Schizophrenia; CRC cis rs2032447 0.531 rs428469 chr6:25898624 G/A cg15691649 chr6:25882328 NA -0.56 -7.02 -0.36 1.3e-11 Intelligence (multi-trait analysis); CRC cis rs7493 0.755 rs2375001 chr7:94964640 A/T cg04155289 chr7:94953770 PON1 -0.55 -7.01 -0.36 1.33e-11 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs801193 0.527 rs2707837 chr7:66181073 G/C cg11764359 chr7:65958608 NA 0.59 8.79 0.44 8.46e-17 Aortic root size; CRC cis rs9611565 0.512 rs4512 chr22:42206084 G/C cg03806693 chr22:41940476 POLR3H -1.08 -12.91 -0.58 3.99e-31 Vitiligo; CRC cis rs8177253 0.898 rs8177258 chr3:133480387 C/A cg08048268 chr3:133502702 NA -0.36 -6.83 -0.35 4.08e-11 Iron status biomarkers; CRC cis rs6933660 0.745 rs6912830 chr6:151743629 A/C cg14416726 chr6:151773293 C6orf211;RMND1 -0.6 -9.09 -0.45 9.19e-18 Menarche (age at onset); CRC cis rs7131987 0.650 rs3782509 chr12:29453778 G/A cg09582351 chr12:29534625 ERGIC2 -0.33 -7.1 -0.36 7.58e-12 QT interval; CRC cis rs2243480 1.000 rs34933526 chr7:65383199 A/G cg12463550 chr7:65579703 CRCP 0.63 6.04 0.32 4.17e-9 Diabetic kidney disease; CRC trans rs57590327 0.503 rs7618973 chr3:81619588 C/T cg23387109 chr10:94051229 MARCH5;CPEB3 -0.44 -6.0 -0.31 5.18e-9 Extraversion; CRC cis rs12681288 0.676 rs2701910 chr8:1001246 G/T cg08648136 chr8:956695 NA 0.32 5.75 0.3 2.06e-8 Schizophrenia; CRC cis rs524281 0.861 rs10896094 chr11:65959206 C/T cg16950941 chr11:66035639 RAB1B -0.6 -7.43 -0.38 9.29e-13 Electroencephalogram traits; CRC cis rs10781543 0.817 rs1128874 chr9:139323424 T/C cg14169450 chr9:139327907 INPP5E 0.37 5.82 0.31 1.36e-8 Monocyte percentage of white cells; CRC cis rs62064224 0.589 rs4523973 chr17:30809455 G/A cg25809561 chr17:30822961 MYO1D 0.57 10.63 0.51 7.19e-23 Schizophrenia; CRC cis rs1005277 0.603 rs1998062 chr10:38457652 G/C cg25427524 chr10:38739819 LOC399744 -0.76 -13.39 -0.59 6.42e-33 Extrinsic epigenetic age acceleration; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg11785858 chr4:153858123 NA 0.44 6.0 0.31 5.08e-9 Anxiety disorder; CRC cis rs1568889 1.000 rs61889046 chr11:28297024 A/G cg06544937 chr11:28130018 METT5D1;KIF18A 0.8 11.57 0.54 3.42e-26 Bipolar disorder; CRC trans rs11098499 0.863 rs7657849 chr4:120455494 T/C cg25214090 chr10:38739885 LOC399744 0.65 10.07 0.49 5.96e-21 Corneal astigmatism; CRC cis rs4925325 1.000 rs4925325 chr20:60514224 G/A cg18761221 chr20:60518478 NA -0.71 -11.73 -0.54 9.07e-27 Obesity-related traits; CRC cis rs4713118 0.662 rs464312 chr6:27967591 T/A cg20933634 chr6:27740509 NA 0.42 5.85 0.31 1.21e-8 Parkinson's disease; CRC cis rs477895 0.938 rs28395875 chr11:64024048 G/C cg18225595 chr11:63971243 STIP1 0.58 6.65 0.34 1.22e-10 Mean platelet volume; CRC cis rs9303280 0.901 rs869402 chr17:38068043 C/T cg17344932 chr17:38183730 MED24;SNORD124 0.36 5.69 0.3 2.76e-8 Self-reported allergy; CRC cis rs7932354 0.528 rs11039107 chr11:47157866 G/A cg19486271 chr11:47235900 DDB2 0.46 6.7 0.35 9.27e-11 Bone mineral density (hip);Bone mineral density; CRC cis rs6963495 0.818 rs73190183 chr7:105163022 G/A cg13798780 chr7:105162888 PUS7 0.68 8.08 0.41 1.27e-14 Bipolar disorder (body mass index interaction); CRC cis rs1552244 1.000 rs2272123 chr3:10140115 G/A cg18598329 chr3:10140678 FANCD2;C3orf24 -0.89 -12.17 -0.56 2.25e-28 Alzheimer's disease; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg11454606 chr11:67888949 CHKA -0.39 -6.4 -0.33 5.41e-10 Myopia (pathological); CRC cis rs6835098 1.000 rs10011724 chr4:174088865 A/G cg08422745 chr4:174089978 GALNT7 -0.98 -16.79 -0.68 3.96e-46 Dementia and core Alzheimer's disease neuropathologic changes; CRC cis rs10504229 1.000 rs116995796 chr8:58181960 G/A cg22535103 chr8:58192502 C8orf71 -0.82 -12.28 -0.56 8.9e-29 Developmental language disorder (linguistic errors); CRC cis rs62244186 0.659 rs9873072 chr3:44516496 G/A cg11003573 chr3:44754125 ZNF502 -0.34 -5.77 -0.3 1.8e-8 Depressive symptoms; CRC cis rs9322193 0.923 rs9689723 chr6:149977071 C/A cg00933542 chr6:150070202 PCMT1 0.3 6.21 0.32 1.59e-9 Lung cancer; CRC cis rs7666738 0.830 rs13134819 chr4:98919885 G/C cg05340658 chr4:99064831 C4orf37 0.59 9.19 0.45 4.49e-18 Colonoscopy-negative controls vs population controls; CRC cis rs780096 0.525 rs13388159 chr2:27648284 A/T cg27432699 chr2:27873401 GPN1 -0.57 -8.63 -0.43 2.72e-16 Total body bone mineral density; CRC cis rs28386778 0.734 rs7210724 chr17:61799198 T/C cg23090583 chr17:61904693 PSMC5;FTSJ3 1.03 19.28 0.73 5.63e-56 Prudent dietary pattern; CRC cis rs10771431 1.000 rs11611670 chr12:9385535 C/T cg22349387 chr12:9600060 DDX12 -0.36 -5.65 -0.3 3.51e-8 Breast size; CRC cis rs4665809 1.000 rs6546728 chr2:26276531 G/C cg25036284 chr2:26402008 FAM59B -0.47 -5.91 -0.31 8.67e-9 Gut microbiome composition (summer); CRC cis rs61774743 0.681 rs10749805 chr1:41850182 C/T cg08462924 chr1:41848221 NA 0.4 6.31 0.33 8.85e-10 Intelligence (multi-trait analysis); CRC cis rs13118159 0.509 rs7688922 chr4:1361011 T/C cg02475777 chr4:1388615 CRIPAK 0.5 6.32 0.33 8.35e-10 Longevity; CRC cis rs35000415 0.872 rs2070197 chr7:128589000 T/C cg19972273 chr7:128594194 NA 0.67 5.98 0.31 5.74e-9 Systemic lupus erythematosus; CRC cis rs12594515 1.000 rs12911309 chr15:45985719 G/C cg06207120 chr15:45996521 NA 0.32 7.66 0.39 2.08e-13 Waist circumference;Weight; CRC cis rs6952808 0.756 rs4719311 chr7:1881813 C/T cg04267008 chr7:1944627 MAD1L1 -0.66 -9.66 -0.47 1.29e-19 Bipolar disorder and schizophrenia; CRC cis rs13064411 0.696 rs6769516 chr3:113219905 T/C cg10517650 chr3:113235015 CCDC52 -0.41 -7.18 -0.37 4.55e-12 Response to simvastatin treatment (PCSK9 protein level change); CRC cis rs929596 0.556 rs4477910 chr2:234643737 A/T cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.58 -9.21 -0.45 3.8e-18 Total bilirubin levels in HIV-1 infection; CRC cis rs9287719 0.601 rs6755281 chr2:10769855 T/C cg00105475 chr2:10696890 NA 0.46 7.04 0.36 1.13e-11 Prostate cancer; CRC cis rs9522267 0.535 rs9522291 chr13:112233761 T/C cg10483660 chr13:112241077 NA -0.48 -8.98 -0.44 2.09e-17 Hepatitis; CRC cis rs13108904 0.870 rs12506095 chr4:1262233 T/C cg00684032 chr4:1343700 KIAA1530 0.46 6.86 0.35 3.42e-11 Obesity-related traits; CRC cis rs17767392 0.794 rs61989255 chr14:71729657 G/A cg13720639 chr14:72061746 SIPA1L1 -0.52 -6.36 -0.33 6.63e-10 Mitral valve prolapse; CRC cis rs72634258 0.945 rs12727642 chr1:8046672 C/A cg26816564 chr1:7831052 VAMP3 0.55 6.08 0.32 3.26e-9 Inflammatory bowel disease; CRC cis rs908922 0.676 rs12116609 chr1:152497685 C/T cg23254163 chr1:152506842 NA 0.51 10.18 0.49 2.4e-21 Hair morphology; CRC cis rs6582630 0.519 rs11520262 chr12:38333051 A/G cg26384229 chr12:38710491 ALG10B 0.68 9.51 0.46 4.14e-19 Drug-induced liver injury (flucloxacillin); CRC cis rs9788333 0.962 rs34853044 chr13:21883784 C/T cg21970626 chr13:21893289 NA -0.43 -7.96 -0.4 2.87e-14 Thiazide-induced adverse metabolic effects in hypertensive patients; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg22645636 chr2:55496232 MTIF2 0.48 6.78 0.35 5.75e-11 Response to antipsychotic treatment; CRC cis rs28386778 0.897 rs2156903 chr17:61937179 G/A cg25654072 chr17:61904446 PSMC5;FTSJ3 0.69 10.63 0.51 7.03e-23 Prudent dietary pattern; CRC cis rs6088580 0.634 rs6059824 chr20:33014543 T/C cg24642439 chr20:33292090 TP53INP2 0.38 6.35 0.33 7.3e-10 Glomerular filtration rate (creatinine); CRC cis rs904251 0.861 rs1776456 chr6:37484698 C/G cg25019722 chr6:37503610 NA -0.48 -8.97 -0.44 2.37e-17 Cognitive performance; CRC trans rs13046373 0.905 rs4816372 chr21:32077414 A/T cg21271961 chr1:95285780 SLC44A3 -0.4 -6.14 -0.32 2.39e-9 HDL cholesterol; CRC cis rs11190604 1.000 rs4919465 chr10:102221703 C/T cg16342193 chr10:102329863 NA -0.37 -6.1 -0.32 2.96e-9 Palmitoleic acid (16:1n-7) levels; CRC cis rs1865760 1.000 rs9358893 chr6:25921761 A/G cg17691542 chr6:26056736 HIST1H1C 0.56 8.43 0.42 1.08e-15 Height; CRC cis rs9322193 0.884 rs11155669 chr6:149954637 T/C cg05861140 chr6:150128134 PCMT1 -0.36 -5.92 -0.31 8.26e-9 Lung cancer; CRC cis rs12024301 0.557 rs12047836 chr1:183615880 A/T cg11505048 chr1:183622726 RGL1;APOBEC4 0.81 7.0 0.36 1.42e-11 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs2625529 0.730 rs1481860 chr15:72241857 T/C cg16672083 chr15:72433130 SENP8 0.45 6.43 0.33 4.51e-10 Red blood cell count; CRC cis rs6963495 0.651 rs3892298 chr7:105152187 A/G cg02135003 chr7:105160482 PUS7 -0.9 -11.7 -0.54 1.09e-26 Bipolar disorder (body mass index interaction); CRC cis rs2839186 0.771 rs13046451 chr21:47641373 T/A cg11766577 chr21:47581405 C21orf56 0.52 8.45 0.42 9.53e-16 Testicular germ cell tumor; CRC cis rs10504229 0.724 rs58715581 chr8:58134568 A/G cg22535103 chr8:58192502 C8orf71 -0.7 -9.34 -0.46 1.47e-18 Developmental language disorder (linguistic errors); CRC cis rs9733 0.566 rs112967224 chr1:150677263 G/A cg18016565 chr1:150552671 MCL1 0.46 6.7 0.35 9.26e-11 Tonsillectomy; CRC cis rs12142240 0.698 rs72677596 chr1:46833930 C/T cg14993813 chr1:46806288 NSUN4 -0.5 -6.25 -0.33 1.26e-9 Menopause (age at onset); CRC cis rs10193935 0.901 rs10189710 chr2:42573102 C/G cg27598129 chr2:42591480 NA -0.68 -7.68 -0.39 1.86e-13 Colonoscopy-negative controls vs population controls; CRC cis rs9911578 0.933 rs74370218 chr17:57095212 C/T cg05425664 chr17:57184151 TRIM37 0.52 8.17 0.41 6.53e-15 Intelligence (multi-trait analysis); CRC cis rs8180040 0.764 rs4082155 chr3:47125385 G/A cg10298567 chr3:47292165 KIF9 -0.36 -5.76 -0.3 1.93e-8 Colorectal cancer; CRC cis rs34375054 0.660 rs900411 chr12:125612839 C/T cg02766259 chr12:125626809 AACS -0.4 -7.01 -0.36 1.36e-11 Post bronchodilator FEV1/FVC ratio; CRC cis rs67478160 0.643 rs12880821 chr14:104276049 C/T cg01849466 chr14:104193079 ZFYVE21 -0.43 -7.28 -0.37 2.44e-12 Schizophrenia; CRC cis rs1559088 0.901 rs12610053 chr19:33582606 A/G cg27124370 chr19:33622961 WDR88 0.44 6.13 0.32 2.53e-9 Bone ultrasound measurement (broadband ultrasound attenuation); CRC cis rs12449964 0.524 rs4925094 chr17:17569012 C/T cg04398451 chr17:18023971 MYO15A 0.36 6.01 0.31 4.84e-9 Coronary artery disease or ischemic stroke; CRC cis rs17826219 0.714 rs11650821 chr17:28968150 T/C cg13385521 chr17:29058706 SUZ12P 0.61 6.64 0.34 1.28e-10 Body mass index; CRC cis rs972578 0.791 rs5751380 chr22:43227867 G/C cg01576275 chr22:43409880 NA -0.36 -5.68 -0.3 2.96e-8 Mean platelet volume; CRC cis rs10751667 0.600 rs1128419 chr11:1010750 G/A cg23136738 chr11:925521 AP2A2 -0.39 -6.08 -0.32 3.37e-9 Alzheimer's disease (late onset); CRC trans rs1656966 1.000 rs1656966 chr3:186466252 C/T cg05300939 chr11:44587523 CD82 0.4 6.1 0.32 2.92e-9 Myopia (pathological); CRC cis rs1862618 0.529 rs978406 chr5:56259808 A/T cg12311346 chr5:56204834 C5orf35 0.85 11.77 0.54 6.13e-27 Initial pursuit acceleration; CRC cis rs7224737 0.957 rs6503687 chr17:40295397 G/A cg20291162 chr17:40259547 DHX58 -0.55 -8.01 -0.4 2.06e-14 Fibrinogen levels; CRC cis rs826838 0.874 rs10880943 chr12:38734317 C/T cg26384229 chr12:38710491 ALG10B 0.76 10.88 0.51 9.39e-24 Heart rate; CRC cis rs875971 0.545 rs6950988 chr7:65976415 C/T cg05627663 chr7:65219948 SNORA22;CCT6P1 0.55 7.09 0.36 8.14e-12 Aortic root size; CRC cis rs9925964 1.000 rs9925964 chr16:31129895 A/G cg03418659 chr16:31128414 MYST1 0.53 7.71 0.39 1.51e-13 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs9322193 0.884 rs11155679 chr6:150080017 T/C cg04369109 chr6:150039330 LATS1 -0.43 -5.61 -0.3 4.31e-8 Lung cancer; CRC cis rs12048904 0.505 rs4517368 chr1:101255052 C/T cg15686842 chr1:101360669 SLC30A7;EXTL2 -0.51 -6.82 -0.35 4.41e-11 Multiple sclerosis; CRC cis rs864537 0.676 rs1773561 chr1:167421951 C/T cg09179987 chr1:167433047 CD247 0.47 7.04 0.36 1.11e-11 Celiac disease or Rheumatoid arthritis;Celiac disease; CRC cis rs9611565 0.840 rs2234052 chr22:41777241 A/G cg03806693 chr22:41940476 POLR3H -1.02 -13.05 -0.58 1.2e-31 Vitiligo; CRC trans rs703108 0.731 rs7898954 chr10:22323646 A/G cg11913072 chr19:11404605 NA -0.5 -6.19 -0.32 1.8e-9 Monocyte percentage of white cells; CRC cis rs6502050 0.835 rs62078305 chr17:80085326 G/A cg25804541 chr17:80189381 SLC16A3 0.31 5.9 0.31 8.94e-9 Life satisfaction; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg14195377 chr11:60928647 VPS37C 0.38 6.07 0.32 3.43e-9 Liver disease severity in Alagille syndrome; CRC cis rs10463316 0.894 rs7719630 chr5:150760961 C/T cg03212797 chr5:150827313 SLC36A1 -0.5 -7.78 -0.39 9.41e-14 Metabolite levels (Pyroglutamine); CRC cis rs1801251 1.000 rs11676216 chr2:233706368 C/T cg25237894 chr2:233734115 C2orf82 -0.54 -8.79 -0.44 8.63e-17 Coronary artery disease; CRC cis rs57590327 0.555 rs7634258 chr3:81799100 T/C cg07356753 chr3:81810745 GBE1 -0.66 -8.99 -0.44 1.93e-17 Extraversion; CRC cis rs13191362 1.000 rs34637087 chr6:163004064 T/G cg06582575 chr6:163149167 PACRG;PARK2 0.77 10.59 0.5 9.54e-23 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs10504229 1.000 rs67546820 chr8:58168567 G/A cg22535103 chr8:58192502 C8orf71 -0.78 -12.13 -0.56 3.17e-28 Developmental language disorder (linguistic errors); CRC cis rs881375 0.678 rs10985102 chr9:123707497 G/A cg09586646 chr9:123605570 PSMD5;LOC253039 0.44 6.51 0.34 2.82e-10 Rheumatoid arthritis; CRC cis rs6700896 0.931 rs4655584 chr1:66155515 T/G cg04111102 chr1:66153794 NA 0.33 5.81 0.31 1.47e-8 C-reactive protein;Mean corpuscular volume;Mean corpuscular hemoglobin; CRC cis rs16852403 0.571 rs11800119 chr1:178144973 T/G cg00404053 chr1:178313656 RASAL2 0.59 7.56 0.38 4.1e-13 Childhood ear infection; CRC cis rs4319547 0.656 rs3817011 chr12:122819566 C/T cg05707623 chr12:122985044 ZCCHC8 -0.62 -7.83 -0.4 6.73e-14 Body mass index; CRC cis rs1799949 0.965 rs11650913 chr17:41331597 T/C cg23758822 chr17:41437982 NA 0.82 13.92 0.61 5.82e-35 Menopause (age at onset); CRC cis rs12451471 0.559 rs1042396 chr17:78084769 G/A cg12100956 chr17:78086420 GAA -0.39 -6.1 -0.32 2.97e-9 Plateletcrit;Mean corpuscular hemoglobin concentration; CRC cis rs9359856 0.636 rs6454767 chr6:90317335 G/A cg13799429 chr6:90582589 CASP8AP2 0.61 8.25 0.41 3.78e-15 Bipolar disorder; CRC cis rs2836950 0.527 rs2836958 chr21:40623526 T/C cg11890956 chr21:40555474 PSMG1 -0.61 -8.79 -0.44 8.39e-17 Menarche (age at onset); CRC cis rs11167764 1.000 rs7730511 chr5:141480418 T/C cg23435118 chr5:141488016 NDFIP1 -0.46 -7.3 -0.37 2.22e-12 Crohn's disease; CRC trans rs11098499 0.909 rs79026312 chr4:120440677 C/A cg25214090 chr10:38739885 LOC399744 0.64 9.9 0.48 2.14e-20 Corneal astigmatism; CRC cis rs17443541 0.507 rs4675716 chr2:200463370 A/C cg03741458 chr2:200468445 NA 0.35 5.63 0.3 3.93e-8 Intelligence (multi-trait analysis); CRC cis rs780096 0.526 rs7602534 chr2:27592423 C/T cg12000995 chr2:27665139 KRTCAP3 -0.28 -5.63 -0.3 3.96e-8 Total body bone mineral density; CRC cis rs9916302 0.904 rs7208274 chr17:37513796 C/T cg03013999 chr17:37608204 MED1 -0.47 -7.3 -0.37 2.2e-12 Glomerular filtration rate (creatinine); CRC cis rs7617773 0.817 rs35414021 chr3:48293524 G/C cg11946769 chr3:48343235 NME6 0.72 9.58 0.47 2.53e-19 Coronary artery disease; CRC cis rs12586317 0.534 rs28384418 chr14:35452126 C/A cg16230307 chr14:35515116 FAM177A1 0.69 8.94 0.44 2.9e-17 Psoriasis; CRC trans rs7395662 1.000 rs10838975 chr11:48617615 C/T cg21153622 chr11:89784906 NA -0.48 -7.68 -0.39 1.78e-13 HDL cholesterol; CRC cis rs6032067 0.929 rs34412950 chr20:43805132 C/A cg10761708 chr20:43804764 PI3 0.51 5.89 0.31 9.53e-9 Blood protein levels; CRC cis rs2270875 0.660 rs6982719 chr8:132930163 G/T cg24184792 chr8:132919238 EFR3A -0.54 -6.11 -0.32 2.77e-9 Response to cholinesterase inhibitors in Alzheimer's disease; CRC cis rs6912958 0.781 rs13193380 chr6:88297057 G/T cg08069147 chr6:88032118 GJB7;C6orf162 -0.57 -8.57 -0.43 4.19e-16 Monocyte percentage of white cells; CRC cis rs9443645 0.901 rs1354831 chr6:79613576 T/C cg09184832 chr6:79620586 NA -0.52 -9.69 -0.47 1.03e-19 Intelligence (multi-trait analysis); CRC cis rs3785574 0.962 rs2584633 chr17:61879501 T/C cg22520471 chr17:61851767 DDX42;CCDC47 0.47 6.52 0.34 2.63e-10 Height; CRC cis rs6540559 1.000 rs4844895 chr1:209958580 T/C cg22029157 chr1:209979665 IRF6 0.68 9.7 0.47 9.96e-20 Cleft lip with or without cleft palate; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg09378111 chr2:211036309 C2orf67 0.53 7.06 0.36 9.82e-12 Thyroid stimulating hormone; CRC cis rs4730250 0.634 rs11767623 chr7:106792332 C/T cg02696742 chr7:106810147 HBP1 0.56 6.36 0.33 6.77e-10 Osteoarthritis; CRC cis rs875971 0.862 rs778684 chr7:65836403 A/T cg18876405 chr7:65276391 NA 0.51 8.48 0.42 7.47e-16 Aortic root size; CRC cis rs6460942 0.591 rs62448733 chr7:12350526 C/T cg06484146 chr7:12443880 VWDE -0.61 -6.64 -0.34 1.33e-10 Coronary artery disease; CRC cis rs7044106 0.648 rs2031369 chr9:123360294 G/A cg14255062 chr9:123606675 PSMD5;LOC253039 0.38 5.76 0.3 1.93e-8 Hip circumference adjusted for BMI; CRC cis rs6502050 0.835 rs4789738 chr17:80123053 G/A cg13198984 chr17:80129470 CCDC57 0.47 8.35 0.42 1.88e-15 Life satisfaction; CRC cis rs736801 0.607 rs11746555 chr5:131727033 G/A cg12564285 chr5:131593104 PDLIM4 0.34 5.8 0.3 1.6e-8 Breast cancer;Mosquito bite size; CRC cis rs3126085 0.935 rs11204934 chr1:152176848 C/A cg09127314 chr1:152161683 NA -0.51 -5.89 -0.31 9.59e-9 Atopic dermatitis; CRC cis rs4629180 1.000 rs974374 chr2:102105846 C/T cg01388757 chr2:102091195 RFX8 0.59 8.06 0.41 1.43e-14 Chronic rhinosinusitis with nasal polyps; CRC cis rs13256369 0.851 rs11249890 chr8:8565245 G/T cg06636001 chr8:8085503 FLJ10661 0.48 5.99 0.31 5.46e-9 Obesity-related traits; CRC cis rs427941 0.595 rs201477 chr7:101746915 G/A cg06246474 chr7:101738831 CUX1 0.43 6.62 0.34 1.45e-10 Plasma omega-3 polyunsaturated fatty acid level (eicosapentaenoic acid); CRC trans rs8123881 0.733 rs7268466 chr20:15810676 C/T cg23439141 chr13:113951774 LAMP1 0.54 6.22 0.32 1.51e-9 Body mass index; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg18959360 chr18:43684205 ATP5A1;HAUS1 0.44 6.6 0.34 1.63e-10 Response to antipsychotic treatment; CRC cis rs9921222 0.597 rs7193109 chr16:413523 T/G cg26913058 chr16:419975 MRPL28 -0.39 -5.68 -0.3 3.03e-8 Bone mineral density (spine);Bone mineral density; CRC cis rs243505 0.559 rs2072407 chr7:148508833 A/G cg09806900 chr7:148480153 CUL1 0.55 7.71 0.39 1.5e-13 Inflammatory bowel disease;Crohn's disease; CRC cis rs9916302 0.861 rs11658219 chr17:37709782 G/A cg03013999 chr17:37608204 MED1 0.46 7.0 0.36 1.41e-11 Glomerular filtration rate (creatinine); CRC cis rs4148883 0.675 rs10015824 chr4:100074544 C/G cg13256891 chr4:100009986 ADH5 0.42 6.08 0.32 3.28e-9 Alcohol dependence; CRC cis rs477895 0.838 rs1058735 chr11:64000410 C/G cg18225595 chr11:63971243 STIP1 0.61 7.85 0.4 5.9e-14 Mean platelet volume; CRC cis rs7726839 0.540 rs55929359 chr5:595956 C/G cg09021430 chr5:549028 NA -0.72 -8.21 -0.41 5.08e-15 Obesity-related traits; CRC cis rs7666738 0.791 rs28579101 chr4:98843203 T/C cg05340658 chr4:99064831 C4orf37 0.55 7.99 0.4 2.22e-14 Colonoscopy-negative controls vs population controls; CRC trans rs747334 0.791 rs2901176 chr10:92743250 G/A cg15865243 chr12:34496342 NA 0.33 6.04 0.32 4.19e-9 Fibroblast growth factor basic levels; CRC cis rs4073582 0.595 rs528842 chr11:66032390 G/A cg14036092 chr11:66035641 RAB1B 0.57 9.23 0.45 3.27e-18 Gout; CRC trans rs9650657 0.504 rs10108347 chr8:11033517 G/C cg06636001 chr8:8085503 FLJ10661 -0.54 -8.56 -0.43 4.48e-16 Neuroticism; CRC cis rs1799949 0.965 rs34633610 chr17:41419385 A/G cg01879757 chr17:41196368 BRCA1 -0.41 -6.05 -0.32 4.03e-9 Menopause (age at onset); CRC cis rs3862030 0.720 rs11593971 chr10:104234090 C/G cg11453585 chr10:104263688 ACTR1A;SUFU -0.8 -14.29 -0.62 2.27e-36 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for body mass index; CRC cis rs4730250 0.707 rs6946931 chr7:106788621 G/T cg02696742 chr7:106810147 HBP1 -0.54 -6.13 -0.32 2.48e-9 Osteoarthritis; CRC cis rs780096 0.546 rs1260320 chr2:27722416 A/G cg12000995 chr2:27665139 KRTCAP3 0.29 6.04 0.32 4.07e-9 Total body bone mineral density; CRC cis rs11711311 0.955 rs12636536 chr3:113474226 G/A cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.51 -6.91 -0.36 2.49e-11 IgG glycosylation; CRC cis rs9611565 0.512 rs5751153 chr22:42156561 T/C cg06634786 chr22:41940651 POLR3H 0.65 7.25 0.37 3e-12 Vitiligo; CRC cis rs4664293 0.609 rs357033 chr2:160494473 T/C cg08347373 chr2:160653686 CD302 -0.39 -6.68 -0.35 1.03e-10 Monocyte percentage of white cells; CRC cis rs7737355 0.947 rs2108871 chr5:131089044 A/C cg06307176 chr5:131281290 NA 0.43 6.39 0.33 5.8e-10 Life satisfaction; CRC cis rs11711311 1.000 rs7649590 chr3:113447267 T/C cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.51 -6.98 -0.36 1.64e-11 IgG glycosylation; CRC cis rs60843830 1.000 rs59937473 chr2:271797 G/A cg25945732 chr2:264204 ACP1;SH3YL1 0.71 11.85 0.55 3.15e-27 Spherical equivalent (joint analysis main effects and education interaction); CRC cis rs2011503 0.882 rs10407933 chr19:19364319 A/G cg11584989 chr19:19387371 SF4 0.48 5.99 0.31 5.51e-9 Bipolar disorder; CRC cis rs250677 0.687 rs10040624 chr5:148437579 A/G cg23229984 chr5:148520753 ABLIM3 0.48 6.5 0.34 2.99e-10 Breast cancer; CRC cis rs9611565 0.559 rs7290991 chr22:41964361 C/G cg03806693 chr22:41940476 POLR3H -0.88 -11.06 -0.52 2.22e-24 Vitiligo; CRC cis rs7615952 0.599 rs7631268 chr3:125755664 T/A cg05084668 chr3:125655381 ALG1L -0.44 -6.16 -0.32 2.09e-9 Blood pressure (smoking interaction); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg06825448 chr2:240884925 NA 0.16 5.98 0.31 5.71e-9 Liver disease severity in Alagille syndrome; CRC cis rs7589342 0.929 rs2060036 chr2:106436101 G/A cg16077055 chr2:106428750 NCK2 0.39 5.63 0.3 3.97e-8 Addiction; CRC cis rs7520050 0.667 rs11211176 chr1:46223086 C/T cg06784218 chr1:46089804 CCDC17 -0.33 -5.68 -0.3 2.93e-8 Red blood cell count;Reticulocyte count; CRC trans rs1814175 0.817 rs1794162 chr11:49899506 A/C cg21153622 chr11:89784906 NA -0.38 -6.0 -0.31 5.28e-9 Height; CRC cis rs11190604 1.000 rs11190578 chr10:102238953 C/T cg07080220 chr10:102295463 HIF1AN 0.48 5.77 0.3 1.79e-8 Palmitoleic acid (16:1n-7) levels; CRC cis rs6938 0.534 rs4886636 chr15:75196176 G/A cg17294928 chr15:75287854 SCAMP5 0.51 7.91 0.4 4.02e-14 Breast cancer; CRC cis rs4290604 0.748 rs7594554 chr2:238065981 A/G cg23555395 chr2:238036564 NA -0.62 -6.29 -0.33 1.02e-9 Asthma; CRC cis rs2576037 0.526 rs7240239 chr18:44460037 T/C cg23996704 chr18:44553084 KATNAL2 -0.35 -7.11 -0.36 7.3e-12 Personality dimensions; CRC cis rs600231 0.665 rs1626021 chr11:65226187 A/G cg17120908 chr11:65337727 SSSCA1 -0.55 -8.12 -0.41 9.17e-15 Bone mineral density; CRC trans rs561341 0.739 rs7213369 chr17:30211878 G/A cg20587970 chr11:113659929 NA 0.63 8.2 0.41 5.32e-15 Hip circumference adjusted for BMI; CRC cis rs2404602 0.716 rs17364076 chr15:76760891 C/T cg03037974 chr15:76606532 NA 0.69 12.0 0.55 8.93e-28 Blood metabolite levels; CRC cis rs12410462 0.901 rs2814090 chr1:227658444 C/G cg23173402 chr1:227635558 NA -0.58 -6.72 -0.35 7.93e-11 Major depressive disorder; CRC cis rs801193 1.000 rs2055682 chr7:66260289 A/G cg11764359 chr7:65958608 NA 0.53 8.14 0.41 8.46e-15 Aortic root size; CRC cis rs9903692 0.862 rs4794453 chr17:46184926 C/T cg21215337 chr17:46176117 CBX1 -0.43 -7.95 -0.4 2.95e-14 Pulse pressure; CRC cis rs2361718 0.500 rs8064429 chr17:78096187 A/C cg12100956 chr17:78086420 GAA -0.37 -5.96 -0.31 6.46e-9 Yeast infection; CRC cis rs12760731 0.511 rs10429849 chr1:178611933 G/A cg00404053 chr1:178313656 RASAL2 0.6 6.94 0.36 2.05e-11 Obesity-related traits; CRC cis rs896854 0.967 rs10956933 chr8:95967688 C/G cg09323728 chr8:95962352 TP53INP1 -0.44 -7.25 -0.37 2.97e-12 Type 2 diabetes; CRC cis rs2243480 1.000 rs313809 chr7:65499983 G/A cg18252515 chr7:66147081 NA -1.14 -12.6 -0.57 5.69e-30 Diabetic kidney disease; CRC cis rs72615157 0.697 rs2056726 chr7:99780283 G/A cg00814883 chr7:100076585 TSC22D4 -0.52 -6.21 -0.32 1.57e-9 Lung function (FEV1/FVC); CRC cis rs807029 0.533 rs3740487 chr10:102750783 C/A cg04662943 chr10:102668895 NA 0.59 7.18 0.37 4.66e-12 Ejection fraction in Tripanosoma cruzi seropositivity; CRC cis rs9611565 0.694 rs202639 chr22:41856137 T/A cg03806693 chr22:41940476 POLR3H 1.08 14.62 0.63 1.25e-37 Vitiligo; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg25404069 chr7:150924520 ABCF2 0.43 6.2 0.32 1.65e-9 Anxiety disorder; CRC trans rs1005277 0.579 rs1740737 chr10:38499365 G/T cg27523141 chr10:43048294 ZNF37B 0.46 6.63 0.34 1.36e-10 Extrinsic epigenetic age acceleration; CRC trans rs2243480 1.000 rs316322 chr7:65611233 G/C cg10756647 chr7:56101905 PSPH 0.75 7.61 0.39 2.98e-13 Diabetic kidney disease; CRC cis rs11622475 1.000 rs2269186 chr14:104379912 C/T cg20488157 chr14:104394430 TDRD9 0.65 8.93 0.44 3e-17 Bipolar disorder; CRC cis rs514406 0.861 rs7524476 chr1:53240212 C/T cg27535305 chr1:53392650 SCP2 0.39 7.07 0.36 9.36e-12 Monocyte count; CRC cis rs11112613 0.713 rs68053161 chr12:105950035 G/C cg03607813 chr12:105948248 NA 0.82 10.85 0.51 1.21e-23 Corrected insulin response;Corrected insulin response adjusted for insulin sensitivity index; CRC cis rs7589728 1.000 rs75309929 chr2:88524377 T/C cg18490616 chr2:88469792 THNSL2 0.58 5.73 0.3 2.23e-8 Plasma clusterin levels; CRC cis rs2806561 0.894 rs1738475 chr1:23536891 C/G cg19743168 chr1:23544995 NA 0.38 5.95 0.31 6.82e-9 Height; CRC cis rs4285028 0.948 rs10934565 chr3:121664661 G/A cg20356878 chr3:121714668 ILDR1 -0.47 -6.84 -0.35 3.91e-11 Multiple sclerosis; CRC cis rs9549367 0.713 rs9549682 chr13:113830181 C/T cg00898013 chr13:113819073 PROZ -0.58 -8.22 -0.41 4.72e-15 Platelet distribution width; CRC trans rs2727020 0.729 rs10839268 chr11:49380328 G/A cg11707556 chr5:10655725 ANKRD33B -0.36 -6.61 -0.34 1.58e-10 Coronary artery disease; CRC cis rs853679 0.527 rs213228 chr6:28331252 A/C cg06470822 chr6:28175283 NA 0.44 5.92 0.31 7.96e-9 Depression; CRC trans rs7267979 0.816 rs374701 chr20:25483616 A/G cg17903999 chr18:56338584 MALT1 -0.4 -6.54 -0.34 2.3e-10 Liver enzyme levels (alkaline phosphatase); CRC cis rs72627509 0.951 rs6554401 chr4:57825336 C/G cg26694713 chr4:57773883 REST 0.47 5.71 0.3 2.52e-8 Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); CRC trans rs2228479 0.850 rs11076623 chr16:89844120 G/T cg21302420 chr1:112162376 RAP1A 0.72 5.96 0.31 6.33e-9 Skin colour saturation; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg09698166 chr20:21106763 PLK1S1 0.48 6.9 0.36 2.66e-11 Response to antipsychotic treatment; CRC trans rs1814175 0.587 rs847628 chr11:49927064 A/T cg11707556 chr5:10655725 ANKRD33B -0.52 -9.95 -0.48 1.49e-20 Height; CRC cis rs7914558 1.000 rs7896547 chr10:104866958 A/G cg15744005 chr10:104629667 AS3MT -0.34 -7.29 -0.37 2.38e-12 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs77861329 1.000 rs72964044 chr3:52092670 G/C cg08692210 chr3:52188851 WDR51A 0.88 8.43 0.42 1.1e-15 Macrophage inflammatory protein 1b levels; CRC trans rs4130344 0.935 rs11725623 chr4:159732671 A/G cg02106828 chr1:236959224 MTR -0.42 -6.22 -0.32 1.49e-9 Intelligence (multi-trait analysis); CRC cis rs1059312 1.000 rs7970815 chr12:129288366 G/A cg21616243 chr12:129299702 MGC16384;SLC15A4 -0.67 -11.05 -0.52 2.42e-24 Systemic lupus erythematosus; CRC cis rs7811142 0.830 rs41280971 chr7:99954457 G/T cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.94 12.7 0.57 2.49e-30 Platelet count; CRC cis rs28386778 0.799 rs2727322 chr17:61921706 G/A cg06601766 chr17:61851465 DDX42;CCDC47 0.42 5.8 0.3 1.53e-8 Prudent dietary pattern; CRC cis rs881375 0.678 rs7021049 chr9:123683982 G/T cg09586646 chr9:123605570 PSMD5;LOC253039 0.45 6.66 0.34 1.16e-10 Rheumatoid arthritis; CRC cis rs3091242 0.967 rs665372 chr1:25719235 A/C cg23205692 chr1:25664452 TMEM50A 0.41 5.82 0.31 1.37e-8 Erythrocyte sedimentation rate; CRC cis rs780096 0.526 rs3845686 chr2:27655447 T/G cg17158414 chr2:27665306 KRTCAP3 -0.3 -6.33 -0.33 8e-10 Total body bone mineral density; CRC cis rs9309473 0.861 rs6546856 chr2:73837751 T/C cg20560298 chr2:73613845 ALMS1 -0.46 -5.65 -0.3 3.55e-8 Metabolite levels; CRC cis rs9322193 0.923 rs9800806 chr6:150061486 G/T cg13206674 chr6:150067644 NUP43 0.68 10.39 0.5 4.69e-22 Lung cancer; CRC cis rs3806843 0.735 rs778596 chr5:140037272 G/A cg19875535 chr5:140030758 IK -0.64 -10.76 -0.51 2.49e-23 Depressive symptoms (multi-trait analysis); CRC cis rs6088590 1.000 rs6119512 chr20:33306904 T/C cg24642439 chr20:33292090 TP53INP2 0.6 10.87 0.51 1.02e-23 Coronary artery disease; CRC trans rs7267979 1.000 rs34645895 chr20:25368373 A/G cg17903999 chr18:56338584 MALT1 0.42 6.98 0.36 1.63e-11 Liver enzyme levels (alkaline phosphatase); CRC trans rs8002861 0.870 rs1348671 chr13:44449505 C/T cg17145862 chr1:211918768 LPGAT1 0.72 14.14 0.61 8.55e-36 Leprosy; CRC cis rs57221529 0.709 rs72703034 chr5:577101 C/T cg14541582 chr5:601475 NA -0.37 -7.13 -0.37 6.35e-12 Lung disease severity in cystic fibrosis; CRC cis rs910187 0.605 rs6124961 chr20:45804467 G/C cg27589058 chr20:45804311 EYA2 -0.43 -8.76 -0.44 1.02e-16 Migraine; CRC cis rs2050392 0.517 rs593400 chr10:30762088 A/G cg18806716 chr10:30721971 MAP3K8 0.57 8.23 0.41 4.4e-15 Inflammatory bowel disease; CRC cis rs7959452 0.605 rs12819406 chr12:69696400 G/T cg22834771 chr12:69754056 YEATS4 -0.4 -5.71 -0.3 2.52e-8 Blood protein levels; CRC cis rs644799 0.648 rs1255182 chr11:95472391 C/T cg03916912 chr11:95522834 CEP57;FAM76B 0.58 9.22 0.45 3.58e-18 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs9747201 1.000 rs9303020 chr17:80163247 C/T cg14673194 chr17:80132900 CCDC57 -0.5 -6.65 -0.34 1.21e-10 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs801193 0.660 rs10950049 chr7:66230860 T/C cg11764359 chr7:65958608 NA 0.61 9.39 0.46 1.03e-18 Aortic root size; CRC cis rs2836974 0.836 rs8129355 chr21:40579869 A/G cg11644478 chr21:40555479 PSMG1 0.81 12.33 0.56 5.44e-29 Cognitive function; CRC cis rs6088580 0.634 rs6059875 chr20:33086090 T/G cg08999081 chr20:33150536 PIGU 0.64 11.5 0.54 5.95e-26 Glomerular filtration rate (creatinine); CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg12059507 chr11:62606662 WDR74 -0.4 -5.98 -0.31 5.94e-9 Myopia (pathological); CRC cis rs17818399 0.597 rs13385693 chr2:46867158 C/T cg26688816 chr2:46740690 ATP6V1E2 -0.4 -5.82 -0.31 1.36e-8 Height; CRC cis rs344364 0.511 rs2982449 chr16:1947878 C/G cg09830162 chr16:1889614 FAHD1;C16orf73 -0.77 -9.36 -0.46 1.32e-18 Glomerular filtration rate in chronic kidney disease; CRC cis rs8072100 0.713 rs1912486 chr17:45515167 A/G cg08085267 chr17:45401833 C17orf57 -0.58 -8.68 -0.43 1.92e-16 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs138880 0.542 rs9616215 chr22:50318834 C/T cg02269571 chr22:50332266 NA -0.97 -9.34 -0.46 1.47e-18 Schizophrenia; CRC cis rs11112613 0.713 rs11112586 chr12:105939816 C/T cg03607813 chr12:105948248 NA 0.64 8.48 0.42 7.7e-16 Corrected insulin response;Corrected insulin response adjusted for insulin sensitivity index; CRC cis rs6500395 1.000 rs6500402 chr16:48687354 C/T cg04672837 chr16:48644449 N4BP1 0.44 6.46 0.34 3.83e-10 Response to tocilizumab in rheumatoid arthritis; CRC cis rs7223966 1.000 rs9891018 chr17:61827856 A/G cg05941027 chr17:61774174 LIMD2 0.35 6.23 0.32 1.42e-9 Hip circumference adjusted for BMI;Body mass index; CRC cis rs758324 0.812 rs12653237 chr5:131241778 C/T cg25547332 chr5:131281432 NA 0.37 5.73 0.3 2.23e-8 Alzheimer's disease in APOE e4- carriers; CRC cis rs7917772 0.503 rs7093285 chr10:104374815 G/C cg22532475 chr10:104410764 TRIM8 -0.35 -6.47 -0.34 3.57e-10 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC cis rs12681288 0.823 rs2701905 chr8:1003482 T/C cg15309053 chr8:964076 NA 0.33 5.87 0.31 1.06e-8 Schizophrenia; CRC cis rs3008870 0.755 rs1535365 chr1:67497613 T/C cg08660285 chr1:67390436 MIER1;WDR78 0.57 8.04 0.41 1.68e-14 Lymphocyte percentage of white cells; CRC cis rs4555082 0.834 rs2816623 chr14:105733295 G/A cg18132624 chr14:105716052 BTBD6;BRF1 -0.5 -8.0 -0.4 2.13e-14 Mean platelet volume;Platelet distribution width; CRC cis rs2882667 0.728 rs10037071 chr5:138277847 A/G cg09476006 chr5:138032270 NA 0.57 9.88 0.48 2.58e-20 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs270601 0.770 rs10463891 chr5:131597392 C/T cg18301423 chr5:131593218 PDLIM4 -0.47 -8.81 -0.44 7.24e-17 Acylcarnitine levels; CRC cis rs9287719 0.967 rs6755548 chr2:10746126 A/G cg00105475 chr2:10696890 NA 0.45 7.15 0.37 5.48e-12 Prostate cancer; CRC cis rs9914988 0.943 rs59461345 chr17:27151852 G/T cg07195577 chr17:27052828 TLCD1 0.41 5.92 0.31 7.89e-9 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC trans rs1005277 0.579 rs2474599 chr10:38438939 A/G cg11292332 chr7:45801988 SEPT13 -0.34 -6.16 -0.32 2.12e-9 Extrinsic epigenetic age acceleration; CRC cis rs4689592 0.503 rs11937667 chr4:7057037 C/G cg06697600 chr4:7070879 GRPEL1 0.54 6.99 0.36 1.58e-11 Monocyte percentage of white cells; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg06568038 chr16:30669663 NA 0.44 6.37 0.33 6.22e-10 Intelligence (multi-trait analysis); CRC cis rs17376456 0.569 rs7702348 chr5:93065683 A/G cg25358565 chr5:93447407 FAM172A -0.5 -6.08 -0.32 3.35e-9 Diabetic retinopathy; CRC cis rs7208859 0.623 rs56378576 chr17:29010120 C/T cg19761014 chr17:28927070 LRRC37B2 0.6 5.89 0.31 9.61e-9 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs755249 0.567 rs2036463 chr1:39688075 G/A cg18385671 chr1:39797026 MACF1 -0.43 -6.13 -0.32 2.48e-9 Peripheral arterial disease (traffic-related air pollution interaction); CRC trans rs61931739 0.500 rs7310237 chr12:34483435 G/A cg13010199 chr12:38710504 ALG10B 0.44 6.28 0.33 1.06e-9 Morning vs. evening chronotype; CRC cis rs875971 0.862 rs1981799 chr7:65955559 T/C cg18912574 chr7:65842487 NCRNA00174 0.36 6.1 0.32 2.99e-9 Aortic root size; CRC cis rs4713118 0.868 rs35069907 chr6:27746692 T/C cg15845792 chr6:28175446 NA 0.69 7.6 0.39 3.01e-13 Parkinson's disease; CRC cis rs9462027 0.628 rs7752522 chr6:34760583 T/C cg07306190 chr6:34760872 UHRF1BP1 -0.34 -6.05 -0.32 4.04e-9 Systemic lupus erythematosus; CRC cis rs45544231 0.544 rs7193453 chr16:52565150 C/T cg09051775 chr16:52580266 TOX3 -0.4 -6.52 -0.34 2.6200000000000003e-10 Restless legs syndrome; CRC cis rs7191439 0.674 rs4782429 chr16:88792097 A/G cg27087555 chr16:88793112 FAM38A -1.43 -15.33 -0.65 2.03e-40 Plateletcrit; CRC cis rs796364 0.806 rs74706215 chr2:200941367 T/C cg25936922 chr2:200820526 C2orf60;C2orf47 -0.68 -6.47 -0.34 3.5e-10 Schizophrenia; CRC cis rs3812762 0.871 rs3862352 chr11:8818020 C/T cg21881798 chr11:8931708 C11orf17;ST5 -0.42 -6.2 -0.32 1.68e-9 Hypospadias; CRC cis rs1218582 0.774 rs11264284 chr1:154875793 C/T cg24250549 chr1:154909240 PMVK 0.59 9.6 0.47 2.13e-19 Prostate cancer; CRC cis rs6908034 0.546 rs74514942 chr6:19810520 G/A cg02682789 chr6:19804855 NA 0.81 6.48 0.34 3.35e-10 Endometriosis;Deep ovarian and/or rectovaginal disease with dense adhesions; CRC cis rs7772486 0.597 rs1970306 chr6:146154543 A/G cg23711669 chr6:146136114 FBXO30 0.66 9.83 0.48 3.67e-20 Lobe attachment (rater-scored or self-reported); CRC cis rs798554 0.660 rs2527687 chr7:2838485 G/A cg19717773 chr7:2847554 GNA12 -0.5 -8.16 -0.41 7.42e-15 Height; CRC cis rs904251 0.523 rs1776454 chr6:37482099 C/T cg25019722 chr6:37503610 NA -0.46 -8.64 -0.43 2.42e-16 Cognitive performance; CRC cis rs6496667 0.738 rs56337344 chr15:90988371 A/T cg04176472 chr15:90893244 GABARAPL3 0.59 8.03 0.4 1.71e-14 Rheumatoid arthritis; CRC cis rs2179367 0.881 rs2744432 chr6:149743871 A/C cg16235748 chr6:149772707 ZC3H12D 0.37 5.97 0.31 6.1e-9 Dupuytren's disease; CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg14235568 chr17:73774897 H3F3B 0.38 6.11 0.32 2.82e-9 Obesity-related traits; CRC cis rs748404 0.697 rs473016 chr15:43558823 A/C cg02155558 chr15:43621948 ADAL;LCMT2 0.42 6.25 0.33 1.28e-9 Lung cancer; CRC cis rs6484504 0.576 rs441975 chr11:31233351 C/T cg14844989 chr11:31128820 NA -0.34 -6.0 -0.31 5.16e-9 Red blood cell count; CRC cis rs11997175 1.000 rs7464996 chr8:33770925 G/T ch.8.33884649F chr8:33765107 NA 0.47 7.03 0.36 1.23e-11 Body mass index; CRC cis rs11098499 0.754 rs1849457 chr4:120254355 A/G cg24375607 chr4:120327624 NA 0.47 7.38 0.38 1.26e-12 Corneal astigmatism; CRC cis rs3760982 0.585 rs4803659 chr19:44290235 C/T cg11993925 chr19:44307056 LYPD5 0.58 10.28 0.49 1.08e-21 Breast cancer (estrogen-receptor negative);Breast cancer; CRC cis rs72781680 0.583 rs6731333 chr2:24113354 C/T cg08917208 chr2:24149416 ATAD2B 0.54 6.41 0.33 5.05e-10 Lymphocyte counts; CRC cis rs2115630 0.967 rs11073702 chr15:85310071 G/A cg11189052 chr15:85197271 WDR73 -0.61 -9.94 -0.48 1.54e-20 P wave terminal force; CRC cis rs9649213 0.593 rs12704982 chr7:97926053 C/T cg00277769 chr7:97922759 BAIAP2L1 -0.61 -10.74 -0.51 2.82e-23 Prostate cancer (SNP x SNP interaction); CRC cis rs9916302 0.904 rs9905432 chr17:37555918 C/A cg03013999 chr17:37608204 MED1 -0.47 -7.31 -0.37 2e-12 Glomerular filtration rate (creatinine); CRC cis rs7659604 0.702 rs61217486 chr4:122693973 T/C cg20573242 chr4:122745356 CCNA2 0.52 7.58 0.39 3.66e-13 Type 2 diabetes; CRC cis rs9583531 0.509 rs9521923 chr13:111405462 C/T cg24331049 chr13:111365604 ING1 -0.55 -5.73 -0.3 2.27e-8 Coronary artery disease; CRC cis rs10540 1.000 rs61876323 chr11:462855 G/A cg11503833 chr11:492997 NA 0.56 5.89 0.31 9.64e-9 Body mass index; CRC trans rs7267979 0.714 rs2474763 chr20:25241295 A/G cg17903999 chr18:56338584 MALT1 -0.42 -6.59 -0.34 1.73e-10 Liver enzyme levels (alkaline phosphatase); CRC cis rs4743820 0.620 rs10991784 chr9:93917094 T/C cg14446406 chr9:93919335 NA 0.77 13.47 0.6 2.94e-33 Ulcerative colitis;Inflammatory bowel disease; CRC cis rs1707322 0.963 rs12145287 chr1:46325002 C/G cg06784218 chr1:46089804 CCDC17 0.6 10.6 0.5 8.89e-23 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs11212617 0.901 rs10789656 chr11:108024336 T/C cg12106634 chr11:108092400 ATM;NPAT 0.41 5.87 0.31 1.06e-8 Response to metformin in type 2 diabetes (glycemic); CRC cis rs9660992 0.573 rs12126439 chr1:205200720 C/T cg00857998 chr1:205179979 DSTYK 0.43 5.69 0.3 2.83e-8 Mean corpuscular volume;Mean platelet volume; CRC trans rs11098499 0.954 rs11734241 chr4:120416872 A/G cg25214090 chr10:38739885 LOC399744 0.65 10.15 0.49 3.02e-21 Corneal astigmatism; CRC cis rs17155006 0.664 rs402113 chr7:107743664 A/G cg05962710 chr7:107745446 LAMB4 -0.43 -7.6 -0.39 3.06e-13 Pneumococcal bacteremia; CRC cis rs35306767 0.903 rs11253492 chr10:936873 T/C cg20503657 chr10:835505 NA 0.95 11.73 0.54 8.69e-27 Eosinophil percentage of granulocytes; CRC cis rs6952808 0.723 rs4721282 chr7:2025040 A/G cg21782813 chr7:2030301 MAD1L1 0.53 9.59 0.47 2.27e-19 Bipolar disorder and schizophrenia; CRC cis rs6693567 0.565 rs3754217 chr1:150480373 G/T cg04165759 chr1:150448943 RPRD2 0.36 5.9 0.31 9.2e-9 Migraine; CRC cis rs4588572 0.644 rs2115435 chr5:77723700 A/C cg11547950 chr5:77652471 NA -0.51 -7.28 -0.37 2.48e-12 Triglycerides; CRC trans rs2303319 0.504 rs62189043 chr2:162608466 A/T cg18122310 chr12:50236657 BCDIN3D -0.73 -6.35 -0.33 7.23e-10 Cognitive function; CRC cis rs9911578 1.000 rs4482353 chr17:56896834 A/G cg05425664 chr17:57184151 TRIM37 -0.48 -7.57 -0.38 3.89e-13 Intelligence (multi-trait analysis); CRC cis rs3008870 1.000 rs6673462 chr1:67461857 A/C cg08660285 chr1:67390436 MIER1;WDR78 -1.04 -15.24 -0.64 4.66e-40 Lymphocyte percentage of white cells; CRC trans rs58106596 0.800 rs11675826 chr2:232565507 T/C cg01370599 chr3:116745421 NA 0.51 6.84 0.35 3.95e-11 White blood cell count;Lymphocyte counts; CRC cis rs10504229 0.817 rs114173899 chr8:58170640 G/T cg22535103 chr8:58192502 C8orf71 -0.82 -12.22 -0.56 1.44e-28 Developmental language disorder (linguistic errors); CRC cis rs2576037 0.526 rs10853544 chr18:44474194 T/C cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.65 -10.61 -0.5 8.17e-23 Personality dimensions; CRC cis rs7811142 1.000 rs6972167 chr7:100080013 G/T cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.73 9.96 0.48 1.33e-20 Platelet count; CRC cis rs910316 0.763 rs4556 chr14:75476071 G/C cg03030879 chr14:75389066 RPS6KL1 -0.43 -6.48 -0.34 3.38e-10 Height; CRC cis rs6456156 0.565 rs7750209 chr6:167482895 T/G cg07741184 chr6:167504864 NA 0.38 6.65 0.34 1.21e-10 Primary biliary cholangitis; CRC cis rs12762955 0.561 rs7918118 chr10:1042823 C/A cg19847866 chr10:1019161 NA 0.4 5.82 0.31 1.43e-8 Response to angiotensin II receptor blocker therapy; CRC cis rs9916302 0.800 rs8069451 chr17:37504933 C/T cg03013999 chr17:37608204 MED1 0.47 7.22 0.37 3.74e-12 Glomerular filtration rate (creatinine); CRC cis rs561341 1.000 rs550264 chr17:30317540 G/T cg00745463 chr17:30367425 LRRC37B -0.88 -9.71 -0.47 9.33e-20 Hip circumference adjusted for BMI; CRC cis rs7618915 0.547 rs12486847 chr3:52691112 T/C cg18404041 chr3:52824283 ITIH1 -0.44 -9.03 -0.45 1.49e-17 Bipolar disorder; CRC cis rs4237845 0.537 rs1599931 chr12:58258850 A/G cg00677455 chr12:58241039 CTDSP2 0.8 11.45 0.53 8.99e-26 Intelligence (multi-trait analysis); CRC cis rs1008375 1.000 rs4698634 chr4:17630192 A/C cg16339924 chr4:17578868 LAP3 -0.52 -7.09 -0.36 8.22e-12 Parasitemia in Tripanosoma cruzi seropositivity; CRC trans rs877282 0.898 rs11253338 chr10:759559 C/T cg22713356 chr15:30763199 NA 1.03 11.91 0.55 1.98e-27 Uric acid levels; CRC cis rs2404602 0.631 rs9646213 chr15:76807672 G/C cg03037974 chr15:76606532 NA 0.72 12.33 0.56 5.8e-29 Blood metabolite levels; CRC cis rs294883 0.858 rs569882 chr6:159678599 C/G cg14500486 chr6:159655392 FNDC1 0.37 6.14 0.32 2.31e-9 Coronary artery disease; CRC cis rs10751667 1.000 rs10902233 chr11:925510 A/G cg23136738 chr11:925521 AP2A2 -0.54 -8.74 -0.43 1.22e-16 Alzheimer's disease (late onset); CRC cis rs6687430 0.526 rs7555790 chr1:10613167 A/G cg17425144 chr1:10567563 PEX14 -0.46 -9.46 -0.46 6.09e-19 Hand grip strength; CRC cis rs13064411 0.542 rs9874747 chr3:113221258 G/A cg18753928 chr3:113234510 CCDC52 -0.54 -8.34 -0.42 2.12e-15 Response to simvastatin treatment (PCSK9 protein level change); CRC cis rs727505 0.954 rs1568883 chr7:124710761 G/A cg23710748 chr7:124431027 NA -0.79 -13.82 -0.61 1.39e-34 Lewy body disease; CRC trans rs58688157 0.705 rs7122021 chr11:595810 A/G cg19188899 chr13:112838565 NA -0.42 -6.45 -0.34 3.93e-10 Systemic lupus erythematosus; CRC cis rs3785574 1.000 rs7223257 chr17:61787684 T/C cg06601766 chr17:61851465 DDX42;CCDC47 0.59 8.41 0.42 1.24e-15 Height; CRC cis rs7107174 1.000 rs11237468 chr11:78072833 A/G cg02023728 chr11:77925099 USP35 0.49 8.61 0.43 3.05e-16 Testicular germ cell tumor; CRC cis rs6502050 0.835 rs6502067 chr17:80111205 A/G cg02741985 chr17:80059408 CCDC57 0.43 7.15 0.37 5.66e-12 Life satisfaction; CRC cis rs4731207 0.596 rs7795605 chr7:124578447 G/A cg23710748 chr7:124431027 NA -0.39 -6.12 -0.32 2.67e-9 Cutaneous malignant melanoma; CRC cis rs2072510 0.569 rs17677343 chr12:96397081 T/A cg22491680 chr12:96389547 HAL -0.5 -6.13 -0.32 2.46e-9 Metabolite levels (small molecules and protein measures); CRC cis rs11123170 0.529 rs1015753 chr2:113968803 T/G cg11763394 chr2:113992921 PAX8;LOC440839;LOC654433 0.49 5.85 0.31 1.2e-8 Renal function-related traits (BUN); CRC cis rs6831352 0.918 rs13112733 chr4:100050319 A/T cg12011299 chr4:100065546 ADH4 -0.49 -9.27 -0.45 2.61e-18 Alcohol dependence; CRC cis rs457287 0.772 rs369064 chr9:4832130 G/T cg14182974 chr9:4791918 RCL1 0.39 6.0 0.31 5.21e-9 Platelet count; CRC cis rs3820068 0.705 rs4646109 chr1:15817319 T/C cg27534772 chr1:16042836 PLEKHM2 0.39 6.7 0.35 8.98e-11 Systolic blood pressure; CRC cis rs2739330 0.731 rs2000468 chr22:24241611 G/T cg10819733 chr22:24237672 NA -0.37 -6.43 -0.33 4.47e-10 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs875971 0.660 rs79009421 chr7:66068509 G/C cg00343986 chr7:65444356 GUSB -0.51 -7.57 -0.39 3.86e-13 Aortic root size; CRC cis rs7618915 0.547 rs2336542 chr3:52710636 A/G cg07507251 chr3:52567010 NT5DC2 0.42 6.06 0.32 3.7e-9 Bipolar disorder; CRC cis rs9905704 0.918 rs11657676 chr17:56842043 A/G cg12560992 chr17:57184187 TRIM37 0.53 7.22 0.37 3.69e-12 Testicular germ cell tumor; CRC cis rs7916697 0.593 rs10762198 chr10:70023053 A/G cg06988349 chr10:69991859 ATOH7 -0.38 -7.15 -0.37 5.64e-12 Optic disc area; CRC cis rs9322193 0.962 rs9397022 chr6:150133188 C/T cg04369109 chr6:150039330 LATS1 -0.43 -5.95 -0.31 7.05e-9 Lung cancer; CRC trans rs10242455 0.702 rs41385645 chr7:98974038 A/T cg09045935 chr12:6379348 NA 0.87 7.24 0.37 3.24e-12 Blood metabolite levels; CRC cis rs2836974 0.932 rs13048178 chr21:40561012 G/T cg17971929 chr21:40555470 PSMG1 0.82 11.62 0.54 2.27e-26 Cognitive function; CRC cis rs3796352 0.527 rs11716506 chr3:52944328 C/T cg06204229 chr3:52865917 ITIH4 0.43 5.95 0.31 6.94e-9 Immune reponse to smallpox (secreted IL-2); CRC cis rs4604732 1.000 rs4604732 chr1:247623872 C/T cg12758973 chr1:247694275 LOC148824;OR2C3 -0.37 -5.78 -0.3 1.76e-8 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CRC cis rs7618915 0.524 rs2028216 chr3:52680823 C/T cg07507251 chr3:52567010 NT5DC2 0.46 6.6 0.34 1.68e-10 Bipolar disorder; CRC cis rs2404602 0.692 rs60658665 chr15:77042508 T/C cg22467129 chr15:76604101 ETFA -0.4 -6.59 -0.34 1.78e-10 Blood metabolite levels; CRC cis rs8077889 0.869 rs11713 chr17:41845824 A/G cg25876840 chr17:41920477 NA -0.46 -6.49 -0.34 3.21e-10 Triglycerides; CRC cis rs4654899 0.785 rs9426656 chr1:21505932 T/G cg02927042 chr1:21476669 EIF4G3 -0.39 -6.17 -0.32 2.01e-9 Superior frontal gyrus grey matter volume; CRC cis rs12995491 0.731 rs56188884 chr2:88508657 G/A cg18490616 chr2:88469792 THNSL2 -0.4 -5.8 -0.3 1.53e-8 Response to metformin (IC50); CRC cis rs2153535 0.580 rs1410766 chr6:8525360 T/C cg21535247 chr6:8435926 SLC35B3 0.49 7.52 0.38 5.42e-13 Motion sickness; CRC cis rs933688 1.000 rs1895448 chr5:90743854 C/T cg02339078 chr5:90679543 LOC100129716;ARRDC3 0.92 15.0 0.64 3.93e-39 Smoking behavior; CRC cis rs7527798 0.592 rs11118345 chr1:207854827 A/T cg09232269 chr1:207846808 CR1L -0.45 -7.33 -0.37 1.84e-12 Erythrocyte sedimentation rate; CRC cis rs9381040 0.610 rs2268196 chr6:41021950 C/G cg04346459 chr6:41068666 NFYA;LOC221442 0.42 6.29 0.33 1e-9 Alzheimer's disease (late onset); CRC trans rs4942242 0.663 rs7332737 chr13:44215043 C/T cg26741380 chr15:41871084 TYRO3 -0.46 -6.43 -0.33 4.57e-10 Response to tocilizumab in rheumatoid arthritis; CRC cis rs10883723 0.810 rs2296581 chr10:104242886 G/A cg22532475 chr10:104410764 TRIM8 -0.34 -6.03 -0.32 4.49e-9 Allergic disease (asthma, hay fever or eczema); CRC trans rs17126268 0.502 rs1340396 chr1:102890347 C/G cg18468354 chr14:36993517 NA -0.39 -6.3 -0.33 9.44e-10 Glomerular filtration rate; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg02754225 chr10:76971001 VDAC2 0.4 6.43 0.33 4.59e-10 Liver disease severity in Alagille syndrome; CRC cis rs7412746 0.611 rs111842513 chr1:150712926 G/A cg10589385 chr1:150898437 SETDB1 0.29 6.13 0.32 2.47e-9 Melanoma; CRC cis rs311392 0.554 rs377045 chr8:55098409 A/C cg06042504 chr8:55087323 NA -0.37 -5.87 -0.31 1.06e-8 Pelvic organ prolapse (moderate/severe); CRC cis rs972578 0.868 rs1076118 chr22:43299710 C/T cg01576275 chr22:43409880 NA 0.38 5.91 0.31 8.74e-9 Mean platelet volume; CRC cis rs13256369 0.950 rs13248096 chr8:8577476 C/T cg06671706 chr8:8559999 CLDN23 0.52 7.74 0.39 1.25e-13 Obesity-related traits; CRC cis rs6120849 0.518 rs11696652 chr20:33637060 T/G cg08999081 chr20:33150536 PIGU 0.44 5.73 0.3 2.23e-8 Protein C levels; CRC cis rs6951245 0.554 rs4724294 chr7:1139695 G/A cg26224354 chr7:1096374 C7orf50;GPR146 -0.6 -8.17 -0.41 6.67e-15 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs911555 0.755 rs7148567 chr14:103882234 C/T cg12935359 chr14:103987150 CKB -0.56 -9.03 -0.45 1.52e-17 Intelligence (multi-trait analysis); CRC trans rs9858542 0.903 rs11921590 chr3:49644193 T/C cg21582582 chr3:182698605 DCUN1D1 -0.56 -6.67 -0.35 1.11e-10 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs10504229 1.000 rs73609762 chr8:58192695 A/G cg02290350 chr8:58132656 NA -0.42 -5.96 -0.31 6.62e-9 Developmental language disorder (linguistic errors); CRC cis rs9894429 0.646 rs6565612 chr17:79602820 C/T cg18240062 chr17:79603768 NPLOC4 -0.47 -7.55 -0.38 4.31e-13 Eye color traits; CRC cis rs8051149 0.793 rs12445334 chr16:87871213 G/A cg01412419 chr16:87856264 NA 0.52 7.05 0.36 1.08e-11 Blood metabolite levels; CRC cis rs9399135 0.935 rs4445070 chr6:135309212 C/T cg22676075 chr6:135203613 NA 0.41 6.34 0.33 7.63e-10 Red blood cell count; CRC cis rs2243480 0.901 rs3813708 chr7:65305632 C/A cg12463550 chr7:65579703 CRCP 0.71 6.4 0.33 5.32e-10 Diabetic kidney disease; CRC cis rs2732480 0.500 rs1552550 chr12:48643351 C/A cg21466736 chr12:48725269 NA -0.52 -7.84 -0.4 6.31e-14 Hemoglobin concentration;Red blood cell count;Hematocrit; CRC cis rs763121 0.819 rs3747173 chr22:39069045 A/G cg06544989 chr22:39130855 UNC84B 0.45 6.9 0.36 2.7e-11 Menopause (age at onset); CRC cis rs12477438 0.765 rs6735801 chr2:99657995 G/T cg26064155 chr2:99771622 LIPT1;TSGA10 -0.63 -8.55 -0.43 4.61e-16 Chronic sinus infection; CRC cis rs1401999 1.000 rs6443924 chr3:183679532 A/G cg05044414 chr3:183734942 ABCC5 0.47 8.25 0.41 3.75e-15 Anterior chamber depth; CRC cis rs2549003 1.000 rs2549005 chr5:131827191 C/T cg02551604 chr5:131831745 NA -0.56 -8.6 -0.43 3.28e-16 Asthma (sex interaction); CRC cis rs8141529 0.748 rs132528 chr22:29295898 C/T cg15103426 chr22:29168792 CCDC117 -0.51 -7.15 -0.37 5.64e-12 Lymphocyte counts; CRC cis rs12130219 0.500 rs4845737 chr1:152177539 G/A cg23107878 chr1:152161397 NA 0.43 6.21 0.32 1.58e-9 Inflammatory skin disease; CRC cis rs12024301 0.557 rs6686494 chr1:183622598 C/T cg11505048 chr1:183622726 RGL1;APOBEC4 0.81 7.0 0.36 1.42e-11 Peripheral arterial disease (traffic-related air pollution interaction); CRC trans rs561341 0.883 rs1034626 chr17:30219500 C/G cg20587970 chr11:113659929 NA 0.9 11.42 0.53 1.17e-25 Hip circumference adjusted for BMI; CRC cis rs7772486 0.764 rs7762562 chr6:146158994 T/C cg05347473 chr6:146136440 FBXO30 0.39 5.99 0.31 5.55e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs7945705 0.935 rs2568061 chr11:8886260 A/G cg12365402 chr11:9010492 NRIP3 -0.49 -8.23 -0.41 4.39e-15 Hemoglobin concentration; CRC trans rs11039798 0.764 rs7294013 chr11:48762416 G/A cg03929089 chr4:120376271 NA 0.63 6.06 0.32 3.73e-9 Axial length; CRC cis rs1448094 0.785 rs6539941 chr12:86452813 G/T cg02569458 chr12:86230093 RASSF9 -0.42 -7.04 -0.36 1.11e-11 Major depressive disorder; CRC cis rs9787249 0.915 rs6664570 chr1:40206298 G/A cg24920358 chr1:40204285 PPIE 0.56 8.49 0.42 7.22e-16 Blood protein levels; CRC cis rs853679 0.546 rs200990 chr6:27815823 T/G cg15845792 chr6:28175446 NA 0.73 6.43 0.33 4.37e-10 Depression; CRC cis rs1046896 0.594 rs8070403 chr17:80865404 A/G cg17346650 chr17:80929145 B3GNTL1 0.46 6.81 0.35 4.66e-11 Glycated hemoglobin levels; CRC cis rs1186222 0.505 rs2867803 chr7:75284941 C/A cg05145297 chr7:75264568 HIP1 0.36 6.13 0.32 2.5e-9 Basophil percentage of granulocytes;White blood cell count (basophil);Basophil percentage of white cells; CRC cis rs7618501 0.521 rs11130222 chr3:49901060 A/T cg24308560 chr3:49941425 MST1R -0.44 -6.52 -0.34 2.68e-10 Intelligence (multi-trait analysis); CRC cis rs13088318 0.521 rs2553415 chr3:101095630 T/A cg11279151 chr3:101281821 RG9MTD1 0.4 5.73 0.3 2.32e-8 Allergic disease (asthma, hay fever or eczema); CRC trans rs17685 0.753 rs4732595 chr7:75755139 A/G cg19862616 chr7:65841803 NCRNA00174 0.95 16.84 0.68 2.56e-46 Coffee consumption;Coffee consumption (cups per day); CRC cis rs8072100 0.790 rs6505048 chr17:45674998 G/A cg08085267 chr17:45401833 C17orf57 0.58 8.77 0.44 9.5e-17 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs2688608 0.592 rs10824032 chr10:75528130 G/A cg16540259 chr10:75572220 NDST2 0.38 6.15 0.32 2.26e-9 Inflammatory bowel disease; CRC cis rs7193541 0.662 rs8052367 chr16:74658867 G/A cg01733217 chr16:74700730 RFWD3 1.06 22.74 0.78 1.84e-69 Multiple myeloma; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg00265317 chr16:70472993 ST3GAL2 0.36 5.97 0.31 6.29e-9 Liver disease severity in Alagille syndrome; CRC cis rs2303745 0.589 rs1965717 chr19:17398559 C/T cg02221750 chr19:17393354 ANKLE1 -0.44 -6.66 -0.34 1.14e-10 Systemic lupus erythematosus; CRC cis rs7786808 0.615 rs4909212 chr7:158197037 G/T cg15440763 chr7:158190612 PTPRN2 0.52 8.42 0.42 1.15e-15 Obesity-related traits; CRC cis rs7811142 1.000 rs11764818 chr7:100043055 G/A cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.63 8.1 0.41 1.1e-14 Platelet count; CRC cis rs4862750 0.914 rs1863405 chr4:187874528 G/T cg10295955 chr4:187884368 NA 0.98 23.34 0.79 9.1e-72 Lobe attachment (rater-scored or self-reported); CRC cis rs7618915 0.501 rs3733041 chr3:52731598 T/C cg15147215 chr3:52552868 STAB1 -0.62 -10.5 -0.5 1.96e-22 Bipolar disorder; CRC cis rs12410462 0.681 rs114950580 chr1:227673334 G/C cg04117972 chr1:227635322 NA 0.76 6.15 0.32 2.28e-9 Major depressive disorder; CRC cis rs2243480 1.000 rs160637 chr7:65584318 C/T cg12463550 chr7:65579703 CRCP 0.66 6.15 0.32 2.28e-9 Diabetic kidney disease; CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg15164871 chr12:123380523 VPS37B 0.37 6.0 0.31 5.34e-9 Obesity-related traits; CRC trans rs66573146 1.000 rs66519732 chr4:6990569 C/G cg07817883 chr1:32538562 TMEM39B 1.4 12.18 0.56 1.99e-28 Granulocyte percentage of myeloid white cells; CRC cis rs7605827 0.930 rs4571032 chr2:15685038 A/G cg19274914 chr2:15703543 NA 0.39 5.82 0.31 1.4e-8 Educational attainment (years of education); CRC cis rs7249142 0.506 rs8101388 chr19:19293938 A/C cg12558012 chr19:19281197 LOC729991-MEF2B;MEF2B 0.59 9.18 0.45 5.05e-18 IgG glycosylation; CRC cis rs6460942 1.000 rs117657017 chr7:12318891 T/C cg20607287 chr7:12443886 VWDE -0.64 -6.41 -0.33 5.11e-10 Coronary artery disease; CRC cis rs2019137 0.560 rs11123172 chr2:113984303 C/T cg07594247 chr2:113993304 PAX8;LOC440839;LOC654433 -0.48 -7.52 -0.38 5.37e-13 Lymphocyte counts; CRC cis rs3087591 0.708 rs7406783 chr17:29689980 A/G cg24425628 chr17:29625626 OMG;NF1 0.7 12.97 0.58 2.27e-31 Hip circumference; CRC cis rs8031584 0.781 rs4779498 chr15:31177476 C/T cg08704250 chr15:31115839 NA -0.49 -8.88 -0.44 4.39e-17 Huntington's disease progression; CRC cis rs6933660 0.646 rs3816778 chr6:151773353 G/C cg10883421 chr6:151773342 RMND1;C6orf211 0.8 14.58 0.63 1.69e-37 Menarche (age at onset); CRC cis rs1448094 0.511 rs17280643 chr12:86210154 C/T cg19622623 chr12:86230825 RASSF9 0.35 5.72 0.3 2.44e-8 Major depressive disorder; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg03940137 chr1:200708937 CAMSAP1L1 0.4 6.57 0.34 2.02e-10 Liver disease severity in Alagille syndrome; CRC cis rs12681287 0.547 rs7837569 chr8:87507366 C/T cg27223183 chr8:87520930 FAM82B -0.52 -7.37 -0.38 1.38e-12 Caudate activity during reward; CRC cis rs9296092 0.538 rs80012910 chr6:33519542 G/A cg13560919 chr6:33536144 NA -0.44 -6.2 -0.32 1.71e-9 Age at smoking initiation in chronic obstructive pulmonary disease; CRC cis rs736408 0.677 rs1042779 chr3:52821011 A/G cg18099408 chr3:52552593 STAB1 -0.4 -6.62 -0.34 1.43e-10 Bipolar disorder; CRC cis rs4718428 0.672 rs12530806 chr7:66390724 A/G cg18252515 chr7:66147081 NA -0.55 -7.71 -0.39 1.55e-13 Corneal structure; CRC trans rs13046373 0.905 rs4816372 chr21:32077414 A/T cg26912078 chr2:97523308 ANKRD39 -0.39 -6.13 -0.32 2.54e-9 HDL cholesterol; CRC cis rs11608355 1.000 rs11066523 chr12:109851899 A/G cg19025524 chr12:109796872 NA 0.45 6.55 0.34 2.25e-10 Neuroticism; CRC cis rs801193 0.548 rs6975044 chr7:66227482 C/T cg18876405 chr7:65276391 NA 0.5 8.02 0.4 1.84e-14 Aortic root size; CRC cis rs10504229 0.610 rs7011877 chr8:58147181 C/T cg24829409 chr8:58192753 C8orf71 -0.52 -8.15 -0.41 7.84e-15 Developmental language disorder (linguistic errors); CRC cis rs9322193 0.810 rs62439811 chr6:149961552 C/T cg00933542 chr6:150070202 PCMT1 0.32 6.29 0.33 1.01e-9 Lung cancer; CRC cis rs1448094 0.838 rs11834294 chr12:86311958 C/T cg18827107 chr12:86230957 RASSF9 -0.41 -6.73 -0.35 7.76e-11 Major depressive disorder; CRC cis rs2976388 0.647 rs2164307 chr8:143788831 A/T cg20041105 chr8:143859282 LYNX1 0.44 7.93 0.4 3.35e-14 Urinary tract infection frequency; CRC cis rs6502050 0.799 rs58538819 chr17:80107153 G/C cg19223190 chr17:80058835 NA 0.42 6.58 0.34 1.81e-10 Life satisfaction; CRC cis rs2797160 1.000 rs1418639 chr6:125999940 C/T cg05901451 chr6:126070800 HEY2 -0.38 -5.93 -0.31 7.46e-9 Endometrial cancer; CRC cis rs9322193 0.651 rs9322188 chr6:149909491 A/G cg00933542 chr6:150070202 PCMT1 -0.29 -5.95 -0.31 7e-9 Lung cancer; CRC cis rs6502050 0.799 rs4789674 chr17:80123200 G/A cg22110888 chr17:80059540 CCDC57 0.4 6.31 0.33 9.05e-10 Life satisfaction; CRC cis rs736408 0.609 rs2230534 chr3:52802402 A/C cg07507251 chr3:52567010 NT5DC2 0.42 5.88 0.31 1.03e-8 Bipolar disorder; CRC cis rs537930 0.560 rs877812 chr5:134346304 G/A cg24576358 chr5:134350122 NA 0.32 5.66 0.3 3.35e-8 Height; CRC cis rs873946 0.648 rs12766050 chr10:134549108 G/A cg27286337 chr10:134555280 INPP5A 0.8 9.97 0.48 1.21e-20 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CRC trans rs9929218 0.501 rs12448999 chr16:68815549 T/A cg04657470 chr2:198365150 HSPE1;HSPD1 0.92 15.89 0.66 1.38e-42 Colorectal cancer; CRC cis rs11608355 0.545 rs4766474 chr12:109908084 G/C cg05360138 chr12:110035743 NA 0.78 8.75 0.43 1.15e-16 Neuroticism; CRC cis rs1322512 1.000 rs2800634 chr6:153010414 G/A cg03415253 chr6:152958462 SYNE1 0.39 5.82 0.31 1.37e-8 Tonometry; CRC cis rs7216064 0.954 rs8079291 chr17:65887622 A/G cg12091567 chr17:66097778 LOC651250 -0.67 -7.74 -0.39 1.24e-13 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CRC cis rs4731207 0.698 rs10227821 chr7:124449587 A/G cg23710748 chr7:124431027 NA 0.37 5.96 0.31 6.53e-9 Cutaneous malignant melanoma; CRC cis rs7215564 0.730 rs9901550 chr17:78584464 T/C cg09596252 chr17:78655493 RPTOR 0.57 5.99 0.31 5.49e-9 Myopia (pathological); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg01939414 chr2:103353548 MFSD9 0.47 6.72 0.35 8.03e-11 Response to antipsychotic treatment; CRC cis rs939584 1.000 rs13412197 chr2:653250 A/G cg03610516 chr2:642275 NA -0.42 -5.74 -0.3 2.18e-8 Body mass index; CRC trans rs6500957 0.920 rs17648524 chr16:7459683 C/G cg00292662 chr22:38071168 LGALS1 0.41 6.08 0.32 3.38e-9 Spherical equivalent (joint analysis main effects and education interaction); CRC trans rs9866825 1.000 rs9866825 chr3:8250790 A/C cg24148841 chr6:4949437 CDYL -0.41 -5.97 -0.31 6.08e-9 QT interval; CRC cis rs801193 0.967 rs2707853 chr7:66214010 G/A cg05627663 chr7:65219948 SNORA22;CCT6P1 0.42 6.12 0.32 2.65e-9 Aortic root size; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg20684399 chr9:96338308 PHF2 0.43 6.27 0.33 1.12e-9 Intelligence (multi-trait analysis); CRC cis rs7799006 1.000 rs7787274 chr7:2275993 G/A cg08027265 chr7:2291960 NA -0.36 -5.81 -0.31 1.44e-8 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs2836974 0.897 rs35123057 chr21:40711689 C/T cg17971929 chr21:40555470 PSMG1 0.73 9.9 0.48 2.09e-20 Cognitive function; CRC cis rs9787249 0.957 rs11809515 chr1:40205326 C/A cg02773041 chr1:40204384 PPIE 0.62 9.12 0.45 7.45e-18 Blood protein levels; CRC cis rs17539620 0.624 rs62432735 chr6:154834055 T/C cg20019720 chr6:154832845 CNKSR3 0.5 8.24 0.41 4.01e-15 Lipoprotein (a) levels; CRC cis rs897984 0.513 rs17839568 chr16:31099783 T/C cg00531865 chr16:30841666 NA -0.42 -6.09 -0.32 3.15e-9 Dementia with Lewy bodies; CRC cis rs12540874 0.542 rs4947581 chr7:50565967 G/A cg18232548 chr7:50535776 DDC -0.49 -7.45 -0.38 8.43e-13 Systemic sclerosis; CRC cis rs1008375 1.000 rs10032326 chr4:17630717 A/T cg02297831 chr4:17616191 MED28 0.44 5.94 0.31 7.26e-9 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs10197940 0.662 rs13555 chr2:152333304 C/A cg19508488 chr2:152266495 RIF1 0.54 7.93 0.4 3.56e-14 Lung cancer; CRC cis rs9372498 0.536 rs62424198 chr6:118827247 A/G cg18833306 chr6:118973337 C6orf204 0.45 5.91 0.31 8.35e-9 Diastolic blood pressure; CRC cis rs951366 0.789 rs823121 chr1:205724302 A/G cg14893161 chr1:205819251 PM20D1 -0.82 -12.95 -0.58 2.81e-31 Menarche (age at onset); CRC cis rs7666738 0.830 rs35822567 chr4:98654138 G/A cg05340658 chr4:99064831 C4orf37 0.56 8.43 0.42 1.12e-15 Colonoscopy-negative controls vs population controls; CRC cis rs3749237 1.000 rs11130214 chr3:49735746 C/G cg24308560 chr3:49941425 MST1R 0.39 5.64 0.3 3.62e-8 Resting heart rate; CRC cis rs905456 0.535 rs9813622 chr3:30748940 C/T cg06106510 chr3:30762233 NA 0.37 6.46 0.34 3.72e-10 Positive affect; CRC cis rs11997175 0.546 rs1561913 chr8:33587002 A/T ch.8.33884649F chr8:33765107 NA 0.43 6.69 0.35 9.6e-11 Body mass index; CRC cis rs7309 0.935 rs11884495 chr2:162059969 A/T cg08807892 chr2:162101083 NA 0.45 6.65 0.34 1.21e-10 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Educational attainment; CRC cis rs2836974 0.568 rs2183573 chr21:40574305 A/G cg11890956 chr21:40555474 PSMG1 -0.91 -15.79 -0.66 3.4e-42 Cognitive function; CRC cis rs4132509 1.000 rs2881275 chr1:243918313 G/C cg21452805 chr1:244014465 NA 0.51 7.01 0.36 1.36e-11 RR interval (heart rate); CRC cis rs1555895 0.566 rs11253451 chr10:852885 C/T cg10556349 chr10:835070 NA -0.36 -6.73 -0.35 7.49e-11 Survival in rectal cancer; CRC cis rs8067545 0.611 rs8071274 chr17:20216928 T/C cg13482628 chr17:19912719 NA -0.47 -7.28 -0.37 2.51e-12 Schizophrenia; CRC cis rs12505749 0.542 rs12508008 chr4:57353767 G/A cg06922635 chr4:57371607 ARL9 -0.54 -5.7 -0.3 2.66e-8 Airflow obstruction; CRC trans rs1005277 0.522 rs1208684 chr10:38093936 G/A cg17830980 chr10:43048298 ZNF37B -0.4 -6.16 -0.32 2.07e-9 Extrinsic epigenetic age acceleration; CRC trans rs4927850 0.752 rs7624460 chr3:195748530 C/T cg16724585 chr3:197361211 NA -0.45 -6.74 -0.35 7.15e-11 Pancreatic cancer; CRC trans rs11039798 0.764 rs4357721 chr11:48354907 G/A cg15704280 chr7:45808275 SEPT13 -0.68 -6.73 -0.35 7.6e-11 Axial length; CRC cis rs873946 0.557 rs34854637 chr10:134582962 A/G cg27286337 chr10:134555280 INPP5A 0.73 8.83 0.44 6.4e-17 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CRC cis rs910316 0.967 rs4903285 chr14:75609268 A/T cg08847533 chr14:75593920 NEK9 0.94 18.28 0.71 5.15e-52 Height; CRC cis rs56399783 0.901 rs73049305 chr7:2778755 C/T cg23627948 chr7:2760692 NA 0.47 5.62 0.3 3.98e-8 Childhood ear infection; CRC cis rs6121246 0.609 rs6060627 chr20:30262159 C/T cg18721089 chr20:30220636 NA -0.31 -5.67 -0.3 3.16e-8 Mean corpuscular hemoglobin; CRC cis rs7772486 0.754 rs6915718 chr6:146100676 A/G cg05347473 chr6:146136440 FBXO30 -0.39 -5.8 -0.3 1.58e-8 Lobe attachment (rater-scored or self-reported); CRC cis rs17376456 0.877 rs35075119 chr5:93385457 T/C cg25358565 chr5:93447407 FAM172A 0.98 10.51 0.5 1.85e-22 Diabetic retinopathy; CRC cis rs9435341 0.896 rs1730851 chr1:107596443 A/G cg14671364 chr1:107599128 PRMT6 -0.56 -7.7 -0.39 1.6e-13 Facial morphology (factor 21, depth of nasal alae); CRC cis rs79349575 0.778 rs12950328 chr17:46967061 C/T cg22482690 chr17:47019901 SNF8 0.49 8.16 0.41 7.35e-15 Type 2 diabetes; CRC cis rs3768617 0.510 rs10458355 chr1:183063993 C/T ch.1.3577855R chr1:183094577 LAMC1 0.86 15.19 0.64 7.31e-40 Fuchs's corneal dystrophy; CRC cis rs17152411 0.895 rs7084646 chr10:126585738 T/C cg07906193 chr10:126599966 NA 0.56 6.34 0.33 7.77e-10 Height; CRC cis rs6502050 0.835 rs4789722 chr17:80151881 G/A cg13198984 chr17:80129470 CCDC57 0.44 7.83 0.4 6.88e-14 Life satisfaction; CRC cis rs7591163 0.959 rs2396497 chr2:228724139 T/C cg21577049 chr2:228736449 WDR69 -0.43 -5.77 -0.3 1.8e-8 Blood pressure; CRC cis rs10256972 0.721 rs2030959 chr7:1075906 T/C cg04025307 chr7:1156635 C7orf50 0.52 8.07 0.41 1.3e-14 Longevity;Endometriosis; CRC cis rs7849270 0.921 rs6478864 chr9:131880630 C/G cg13538475 chr9:131942899 NA -0.29 -5.89 -0.31 9.75e-9 Blood metabolite ratios; CRC trans rs7395662 0.963 rs10454482 chr11:48754977 A/G cg21153622 chr11:89784906 NA -0.48 -7.79 -0.39 8.59e-14 HDL cholesterol; CRC cis rs10751667 0.600 rs10751665 chr11:941300 G/A cg01483505 chr11:975446 AP2A2 0.42 6.71 0.35 8.38e-11 Alzheimer's disease (late onset); CRC trans rs4650994 0.544 rs11579513 chr1:178496092 T/C cg27649806 chr9:35101217 STOML2 0.38 6.08 0.32 3.37e-9 HDL cholesterol levels;HDL cholesterol; CRC cis rs7309 0.810 rs11684253 chr2:162034536 G/T cg16506815 chr2:162101123 NA 0.52 8.56 0.43 4.24e-16 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Educational attainment; CRC trans rs61931739 0.500 rs9669027 chr12:34583528 C/T cg13010199 chr12:38710504 ALG10B -0.47 -6.66 -0.34 1.15e-10 Morning vs. evening chronotype; CRC cis rs4713118 0.615 rs9295747 chr6:27736993 G/T cg12273811 chr6:28175739 NA -0.45 -6.34 -0.33 7.49e-10 Parkinson's disease; CRC cis rs6163 0.508 rs11191381 chr10:104493444 C/T cg04362960 chr10:104952993 NT5C2 0.52 6.21 0.32 1.56e-9 Waist circumference;Hip circumference; CRC cis rs4964805 0.954 rs4964812 chr12:104189615 A/G cg02344784 chr12:104178138 NT5DC3 0.56 8.45 0.42 9.23e-16 Attention deficit hyperactivity disorder; CRC cis rs11098499 0.954 rs9993199 chr4:120392873 A/G cg24375607 chr4:120327624 NA -0.49 -7.8 -0.4 8.32e-14 Corneal astigmatism; CRC cis rs6570726 0.967 rs418662 chr6:145848832 A/C cg05347473 chr6:146136440 FBXO30 0.37 5.84 0.31 1.27e-8 Lobe attachment (rater-scored or self-reported); CRC cis rs7615952 0.641 rs7618515 chr3:125790578 C/T cg02772935 chr3:125709198 NA -0.48 -5.73 -0.3 2.33e-8 Blood pressure (smoking interaction); CRC cis rs72945132 0.882 rs55758686 chr11:70172204 C/T cg00319359 chr11:70116639 PPFIA1 0.66 7.32 0.37 1.94e-12 Coronary artery disease; CRC cis rs7493 0.950 rs12704794 chr7:95036133 A/T cg21856205 chr7:94953877 PON1 -0.49 -6.44 -0.33 4.12e-10 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs3796352 0.764 rs34872575 chr3:52986277 G/A cg27565382 chr3:53032988 SFMBT1 0.78 6.26 0.33 1.21e-9 Immune reponse to smallpox (secreted IL-2); CRC cis rs6921919 0.583 rs13201726 chr6:28385551 T/A cg21251018 chr6:28226885 NKAPL 0.4 6.01 0.31 4.96e-9 Autism spectrum disorder or schizophrenia; CRC cis rs28386778 0.897 rs2036911 chr17:61794839 A/T cg06601766 chr17:61851465 DDX42;CCDC47 0.44 5.94 0.31 7.06e-9 Prudent dietary pattern; CRC cis rs7781266 0.790 rs17597439 chr7:133160732 A/C cg03336402 chr7:133662267 EXOC4 0.48 5.66 0.3 3.25e-8 Educational attainment (college completion); CRC cis rs9399135 1.000 rs4896130 chr6:135355118 C/T cg22676075 chr6:135203613 NA 0.4 6.1 0.32 2.95e-9 Red blood cell count; CRC cis rs7833986 0.501 rs72653951 chr8:56961837 G/A cg23139584 chr8:56987506 RPS20;SNORD54 0.85 12.01 0.55 8.69e-28 Height; CRC cis rs6764363 0.527 rs13072907 chr3:279924 G/A cg02057681 chr3:285234 CHL1 0.42 7.12 0.37 6.65e-12 Sudden cardiac arrest; CRC cis rs2180341 0.782 rs6912552 chr6:127722946 C/G cg27446573 chr6:127587934 RNF146 -0.7 -9.79 -0.47 5.08e-20 Breast cancer; CRC cis rs9399135 0.967 rs9399129 chr6:135285148 C/A cg22676075 chr6:135203613 NA 0.42 6.4 0.33 5.49e-10 Red blood cell count; CRC trans rs7615952 0.558 rs7641353 chr3:125339879 T/C cg16558177 chr4:4109446 NA -0.6 -8.45 -0.42 9.75e-16 Blood pressure (smoking interaction); CRC cis rs7666738 0.830 rs34412187 chr4:99010454 A/G cg17366294 chr4:99064904 C4orf37 0.45 7.58 0.39 3.6e-13 Colonoscopy-negative controls vs population controls; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg19909895 chr3:128368930 RPN1 0.52 6.76 0.35 6.36e-11 Thyroid stimulating hormone; CRC cis rs644799 0.526 rs693172 chr11:95636618 A/G cg25622487 chr11:95524042 FAM76B;CEP57 0.52 7.74 0.39 1.22e-13 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs6570726 0.791 rs1509214 chr6:145784606 A/C cg05347473 chr6:146136440 FBXO30 -0.38 -5.91 -0.31 8.67e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs6951245 1.000 rs76388414 chr7:1100694 G/A cg03188948 chr7:1209495 NA 0.65 6.84 0.35 3.8e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs6960043 0.818 rs10228796 chr7:15064190 C/G cg19272540 chr7:15055459 NA -0.21 -5.63 -0.3 3.95e-8 Type 2 diabetes; CRC cis rs9649213 0.574 rs7790229 chr7:97919338 G/A cg00277769 chr7:97922759 BAIAP2L1 -0.62 -10.88 -0.51 9.41e-24 Prostate cancer (SNP x SNP interaction); CRC cis rs801193 0.569 rs11761542 chr7:66218196 G/A cg18252515 chr7:66147081 NA -0.4 -5.78 -0.3 1.77e-8 Aortic root size; CRC cis rs10504229 0.683 rs17802743 chr8:58105897 C/T cg24829409 chr8:58192753 C8orf71 -0.63 -7.7 -0.39 1.59e-13 Developmental language disorder (linguistic errors); CRC cis rs1552244 0.572 rs3894322 chr3:10168965 G/A cg10729496 chr3:10149963 C3orf24 0.48 5.63 0.3 3.81e-8 Alzheimer's disease; CRC cis rs9467773 0.620 rs2451732 chr6:26622904 A/T cg09904177 chr6:26538194 HMGN4 -0.72 -11.47 -0.53 7.63e-26 Intelligence (multi-trait analysis); CRC cis rs911119 0.913 rs2405392 chr20:23569186 C/T cg16589663 chr20:23618590 CST3 0.44 6.06 0.32 3.75e-9 Chronic kidney disease; CRC cis rs4561483 0.771 rs7202234 chr16:11942322 A/G cg08843971 chr16:11963173 GSPT1 0.63 9.94 0.48 1.62e-20 Testicular germ cell tumor; CRC cis rs9910055 0.659 rs7216294 chr17:42251095 T/C cg10896456 chr17:42255109 ASB16;C17orf65 0.44 7.59 0.39 3.41e-13 Total body bone mineral density; CRC cis rs8067545 0.641 rs203482 chr17:19827210 G/A cg04132472 chr17:19861366 AKAP10 0.42 6.44 0.33 4.12e-10 Schizophrenia; CRC cis rs4665809 0.590 rs11552518 chr2:26455127 G/A cg27170947 chr2:26402098 FAM59B 0.6 7.82 0.4 7.45e-14 Gut microbiome composition (summer); CRC cis rs7605827 0.836 rs13019322 chr2:15511270 G/A cg19274914 chr2:15703543 NA 0.38 5.8 0.3 1.59e-8 Educational attainment (years of education); CRC cis rs6674970 0.518 rs6587552 chr1:151018861 C/T cg04469105 chr1:151031679 CDC42SE1;MLLT11 0.48 6.23 0.32 1.42e-9 Childhood ear infection; CRC cis rs2075371 0.863 rs1646635 chr7:134006728 T/C cg02659138 chr7:134003124 SLC35B4 0.42 7.38 0.38 1.32e-12 Mean platelet volume; CRC cis rs1348850 0.914 rs2364854 chr2:178378452 T/A cg22681709 chr2:178499509 PDE11A -0.34 -6.27 -0.33 1.13e-9 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs1109861 0.535 rs7085721 chr10:11242780 G/A cg24910943 chr10:11206320 CUGBP2 -0.29 -7.34 -0.38 1.67e-12 Urinary albumin-to-creatinine ratio; CRC cis rs7786808 0.741 rs4909222 chr7:158228095 C/T cg17401720 chr7:158221031 PTPRN2 -0.46 -7.68 -0.39 1.78e-13 Obesity-related traits; CRC cis rs11971779 0.878 rs4732378 chr7:139120395 C/T cg07862535 chr7:139043722 LUC7L2 0.96 11.6 0.54 2.56e-26 Diisocyanate-induced asthma; CRC cis rs4253772 0.550 rs6008600 chr22:46704676 A/G cg03482458 chr22:46692211 CN5H6.4;GTSE1 0.49 6.16 0.32 2.1e-9 LDL cholesterol;Cholesterol, total; CRC cis rs4919694 1.000 rs4917986 chr10:104630181 T/C cg04362960 chr10:104952993 NT5C2 1.05 9.45 0.46 6.51e-19 Arsenic metabolism; CRC cis rs28386778 0.897 rs2044125 chr17:61863184 A/C cg06601766 chr17:61851465 DDX42;CCDC47 -0.42 -5.74 -0.3 2.12e-8 Prudent dietary pattern; CRC trans rs1814175 0.692 rs1851873 chr11:49937767 A/G cg11707556 chr5:10655725 ANKRD33B -0.38 -7.02 -0.36 1.25e-11 Height; CRC cis rs1992660 0.510 rs6889125 chr5:40412590 A/T cg09067459 chr5:40385259 NA 0.44 7.38 0.38 1.27e-12 Crohn's disease; CRC cis rs2404602 0.716 rs7174953 chr15:76906847 A/C cg23625390 chr15:77176239 SCAPER 0.48 7.03 0.36 1.21e-11 Blood metabolite levels; CRC cis rs736408 0.562 rs12497998 chr3:52793602 C/T cg18099408 chr3:52552593 STAB1 -0.47 -7.89 -0.4 4.63e-14 Bipolar disorder; CRC cis rs2239547 0.618 rs2071041 chr3:52864693 T/G cg18404041 chr3:52824283 ITIH1 -0.36 -7.02 -0.36 1.3e-11 Schizophrenia; CRC cis rs12541635 0.639 rs6415444 chr8:107043797 G/A cg10147462 chr8:107024639 NA 0.6 10.29 0.49 1.05e-21 Age of smoking initiation; CRC cis rs875971 0.862 rs2088655 chr7:65795711 T/C cg12463550 chr7:65579703 CRCP -0.49 -6.58 -0.34 1.85e-10 Aortic root size; CRC cis rs992157 0.735 rs13388024 chr2:219097773 A/G cg04731861 chr2:219085781 ARPC2 -0.32 -6.83 -0.35 4.23e-11 Colorectal cancer; CRC cis rs12476592 0.602 rs959195 chr2:63804125 G/A cg10828910 chr2:63850056 LOC388955 0.49 6.18 0.32 1.84e-9 Childhood ear infection; CRC cis rs2576037 0.899 rs2060417 chr18:44576486 C/A cg19077165 chr18:44547161 KATNAL2 0.5 7.66 0.39 2.05e-13 Personality dimensions; CRC cis rs1865760 1.000 rs6910174 chr6:25904414 C/T cg16482183 chr6:26056742 HIST1H1C 0.55 7.97 0.4 2.55e-14 Height; CRC cis rs9372498 0.572 rs56082110 chr6:118909480 A/G cg24463073 chr6:118973353 C6orf204 0.54 7.13 0.37 6.33e-12 Diastolic blood pressure; CRC cis rs2625529 0.586 rs59975112 chr15:72423710 G/T cg16672083 chr15:72433130 SENP8 0.43 6.64 0.34 1.27e-10 Red blood cell count; CRC cis rs1552244 1.000 rs9827740 chr3:10120531 T/C cg10729496 chr3:10149963 C3orf24 0.5 6.81 0.35 4.67e-11 Alzheimer's disease; CRC cis rs7772486 0.875 rs2224121 chr6:146343214 G/A cg23711669 chr6:146136114 FBXO30 0.67 11.51 0.54 5.52e-26 Lobe attachment (rater-scored or self-reported); CRC cis rs6564851 0.506 rs61227863 chr16:81259814 T/C cg05274606 chr16:81253692 PKD1L2 -0.39 -6.58 -0.34 1.85e-10 Carotenoid and tocopherol levels; CRC cis rs1395 0.778 rs11126918 chr2:27438710 G/A cg14242246 chr2:27434262 C2orf28;SLC5A6 0.42 7.77 0.39 1.02e-13 Blood metabolite levels; CRC cis rs7224737 1.000 rs739637 chr17:40280944 G/C cg20291162 chr17:40259547 DHX58 -0.55 -7.98 -0.4 2.46e-14 Fibrinogen levels; CRC cis rs6598955 0.640 rs6667826 chr1:26531408 T/C cg04990556 chr1:26633338 UBXN11 -0.8 -12.89 -0.58 4.79e-31 Obesity-related traits; CRC cis rs6076065 0.723 rs743024 chr20:23342476 C/T cg11657817 chr20:23433608 CST11 -0.38 -6.04 -0.32 4.16e-9 Facial morphology (factor 15, philtrum width); CRC cis rs6088580 0.634 rs9789792 chr20:32957709 G/A cg08999081 chr20:33150536 PIGU -0.63 -11.8 -0.55 5.1e-27 Glomerular filtration rate (creatinine); CRC cis rs1552244 1.000 rs722509 chr3:10102377 T/A cg00166722 chr3:10149974 C3orf24 0.7 9.53 0.46 3.69e-19 Alzheimer's disease; CRC cis rs832540 0.898 rs170732 chr5:56251777 C/T cg12311346 chr5:56204834 C5orf35 -0.44 -7.0 -0.36 1.44e-11 Coronary artery disease; CRC cis rs57221529 0.709 rs72703090 chr5:598314 C/T cg14541582 chr5:601475 NA -0.36 -7.37 -0.38 1.42e-12 Lung disease severity in cystic fibrosis; CRC trans rs11098499 0.697 rs35280960 chr4:120257059 G/A cg25214090 chr10:38739885 LOC399744 0.51 7.64 0.39 2.35e-13 Corneal astigmatism; CRC cis rs6933660 0.760 rs6904364 chr6:151754273 T/C cg14262678 chr6:151773367 RMND1;C6orf211 0.39 6.02 0.32 4.55e-9 Menarche (age at onset); CRC cis rs6456156 0.792 rs4710183 chr6:167514083 A/G cg07741184 chr6:167504864 NA -0.45 -7.75 -0.39 1.17e-13 Primary biliary cholangitis; CRC cis rs7932354 0.528 rs11039105 chr11:47157677 A/T cg19486271 chr11:47235900 DDB2 0.47 6.85 0.35 3.65e-11 Bone mineral density (hip);Bone mineral density; CRC cis rs4713118 0.869 rs9283882 chr6:27715258 A/C cg25164649 chr6:28176230 NA 0.59 8.32 0.42 2.36e-15 Parkinson's disease; CRC cis rs668210 0.793 rs590531 chr11:65773939 C/A cg02202077 chr11:65769826 EIF1AD;BANF1 -0.55 -6.99 -0.36 1.51e-11 Cerebrospinal fluid biomarker levels; CRC cis rs4332037 0.950 rs62442895 chr7:1936938 G/A cg21155852 chr7:2048760 MAD1L1 -0.51 -6.88 -0.35 3.09e-11 Bipolar disorder; CRC cis rs2011503 1.000 rs11671253 chr19:19604206 C/T cg11584989 chr19:19387371 SF4 0.56 6.35 0.33 7.35e-10 Bipolar disorder; CRC cis rs1158570 0.521 rs10089819 chr8:131172968 C/T cg21674704 chr8:131455249 NA -0.46 -7.01 -0.36 1.39e-11 Platelet count; CRC cis rs9976767 1.000 rs11702374 chr21:43829758 G/A cg23042151 chr21:43824109 UBASH3A -0.33 -5.84 -0.31 1.26e-8 Type 1 diabetes; CRC cis rs2836950 0.545 rs11701805 chr21:40618683 T/C cg11644478 chr21:40555479 PSMG1 -0.48 -7.15 -0.37 5.69e-12 Menarche (age at onset); CRC cis rs3785888 0.548 rs3885731 chr17:45033310 T/C cg16759221 chr17:45003025 GOSR2 -0.72 -10.57 -0.5 1.12e-22 Cleft lip with or without cleft palate; CRC cis rs826838 0.967 rs1486345 chr12:39131677 G/A cg13010199 chr12:38710504 ALG10B -0.41 -5.83 -0.31 1.32e-8 Heart rate; CRC cis rs3736485 0.966 rs28428679 chr15:51913040 A/G cg08986416 chr15:51914746 DMXL2 -0.45 -6.38 -0.33 5.86e-10 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs9303401 0.580 rs34076823 chr17:57114497 C/G cg10487724 chr17:56770010 TEX14;RAD51C 0.68 8.29 0.42 2.96e-15 Cognitive test performance; CRC cis rs12142240 0.698 rs17413701 chr1:46818452 A/G cg14993813 chr1:46806288 NSUN4 -0.48 -6.15 -0.32 2.24e-9 Menopause (age at onset); CRC cis rs4253772 0.591 rs6007795 chr22:46686792 C/G cg03482458 chr22:46692211 CN5H6.4;GTSE1 0.58 8.31 0.42 2.52e-15 LDL cholesterol;Cholesterol, total; CRC cis rs4561483 0.583 rs33636 chr16:11990323 C/G cg08843971 chr16:11963173 GSPT1 -0.51 -7.72 -0.39 1.43e-13 Testicular germ cell tumor; CRC cis rs950169 0.512 rs4374136 chr15:84645007 C/G cg11189052 chr15:85197271 WDR73 0.56 7.07 0.36 9.41e-12 Schizophrenia; CRC cis rs28386778 0.897 rs4968597 chr17:61805747 G/A cg25654072 chr17:61904446 PSMC5;FTSJ3 0.71 10.95 0.52 5.51e-24 Prudent dietary pattern; CRC cis rs11190604 1.000 rs6584383 chr10:102303065 C/G cg16342193 chr10:102329863 NA -0.33 -5.69 -0.3 2.85e-8 Palmitoleic acid (16:1n-7) levels; CRC cis rs394563 0.591 rs11155641 chr6:149648595 G/A cg07828024 chr6:149772892 ZC3H12D 0.52 9.59 0.47 2.31e-19 Dupuytren's disease; CRC cis rs9467711 0.606 rs9379854 chr6:26362854 T/C cg14345882 chr6:26364793 BTN3A2 0.64 5.63 0.3 3.85e-8 Autism spectrum disorder or schizophrenia; CRC trans rs9956878 0.555 rs8085188 chr18:73544676 A/G cg18895155 chr7:99214691 ZNF498 -0.39 -6.34 -0.33 7.75e-10 Obesity-related traits; CRC cis rs9487051 0.735 rs1341272 chr6:109507533 C/T cg21918786 chr6:109611834 NA 0.36 6.23 0.32 1.41e-9 Reticulocyte fraction of red cells; CRC cis rs9311474 0.659 rs1133415 chr3:52575831 G/A cg10802521 chr3:52805072 NEK4 -0.52 -8.3 -0.42 2.76e-15 Electroencephalogram traits; CRC cis rs8180040 0.966 rs11711824 chr3:47468261 C/T cg02527881 chr3:46936655 PTH1R -0.4 -7.64 -0.39 2.43e-13 Colorectal cancer; CRC cis rs2070433 0.800 rs11702190 chr21:47877367 C/T cg05998816 chr21:47859926 PCNT 0.5 5.68 0.3 2.94e-8 Lymphocyte counts; CRC cis rs2197308 0.765 rs12230545 chr12:37927114 C/T cg26384229 chr12:38710491 ALG10B -0.64 -9.62 -0.47 1.8e-19 Morning vs. evening chronotype; CRC cis rs929354 0.772 rs2023977 chr7:156996022 C/G cg17757837 chr7:157058334 UBE3C 0.74 12.6 0.57 5.83e-30 Body mass index; CRC cis rs2075371 0.796 rs12154724 chr7:133943443 G/A cg02659138 chr7:134003124 SLC35B4 0.39 6.54 0.34 2.39e-10 Mean platelet volume; CRC cis rs2243480 1.000 rs2460422 chr7:65601505 C/T cg25985355 chr7:65971099 NA -0.52 -5.98 -0.31 5.86e-9 Diabetic kidney disease; CRC cis rs9910055 0.762 rs2631299 chr17:42219773 G/T cg09913183 chr17:42254507 C17orf65;ASB16 0.57 8.31 0.42 2.55e-15 Total body bone mineral density; CRC cis rs1475911 0.708 rs56185023 chr21:43521538 T/C cg14562523 chr21:43528734 C21orf128;UMODL1 -0.63 -9.87 -0.48 2.64e-20 IgG glycosylation; CRC cis rs977987 0.671 rs9922008 chr16:75335406 T/C cg03315344 chr16:75512273 CHST6 0.56 9.0 0.44 1.84e-17 Dupuytren's disease; CRC cis rs1964356 0.967 rs2953802 chr8:8851881 G/A cg08975724 chr8:8085496 FLJ10661 0.39 5.74 0.3 2.1e-8 Mean corpuscular volume; CRC cis rs9291683 0.588 rs35866697 chr4:10018604 C/A cg11266682 chr4:10021025 SLC2A9 0.54 11.43 0.53 1.09e-25 Bone mineral density; CRC cis rs17162190 0.698 rs56241541 chr1:26840904 C/T cg17456097 chr1:26900765 RPS6KA1 0.42 6.15 0.32 2.22e-9 Mean corpuscular volume; CRC cis rs425277 0.958 rs262660 chr1:2086757 A/G cg24578937 chr1:2090814 PRKCZ 0.66 11.79 0.54 5.41e-27 Height; CRC cis rs7613875 0.620 rs7634441 chr3:50071677 G/A cg05623727 chr3:50126028 RBM5 -0.56 -9.68 -0.47 1.11e-19 Body mass index; CRC cis rs7208859 0.673 rs216409 chr17:28906269 C/T cg19761014 chr17:28927070 LRRC37B2 -0.5 -6.32 -0.33 8.69e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs2072510 0.932 rs2070614 chr12:96390336 T/C cg22491680 chr12:96389547 HAL -0.39 -6.06 -0.32 3.82e-9 Metabolite levels (small molecules and protein measures); CRC cis rs6546550 0.935 rs3771541 chr2:70031797 C/G cg02498382 chr2:70120550 SNRNP27 -0.48 -7.76 -0.39 1.06e-13 Prevalent atrial fibrillation; CRC cis rs951366 0.789 rs823137 chr1:205738302 C/T cg07157834 chr1:205819609 PM20D1 0.77 11.75 0.54 7.18e-27 Menarche (age at onset); CRC cis rs1707322 1.000 rs10890378 chr1:46410657 A/G cg06784218 chr1:46089804 CCDC17 -0.52 -9.17 -0.45 5.13e-18 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC trans rs1005277 0.541 rs2505193 chr10:38394638 G/C cg11292332 chr7:45801988 SEPT13 -0.35 -6.26 -0.33 1.19e-9 Extrinsic epigenetic age acceleration; CRC cis rs7781557 0.640 rs73192025 chr7:102591489 T/C cg18108683 chr7:102477205 FBXL13 -0.49 -5.76 -0.3 1.9e-8 Colorectal adenoma (advanced); CRC cis rs9747201 0.925 rs8072670 chr17:80159566 T/C cg14673194 chr17:80132900 CCDC57 -0.51 -6.79 -0.35 5.12e-11 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs3858526 0.959 rs11039699 chr11:5951091 G/A cg13902645 chr11:5959945 NA -0.64 -9.0 -0.44 1.81e-17 DNA methylation (variation); CRC cis rs1065852 0.526 rs9611711 chr22:42410695 G/A cg22189786 chr22:42395067 WBP2NL 0.43 6.25 0.33 1.27e-9 Response to serotonin reuptake inhibitors in major depressive disorder (plasma drug and metabolite levels); CRC cis rs868036 1.000 rs1026736 chr15:68101813 T/C cg05925327 chr15:68127851 NA -0.31 -6.0 -0.31 5.18e-9 Restless legs syndrome; CRC cis rs6089584 0.888 rs6089624 chr20:60619907 C/G cg23463467 chr20:60627584 TAF4 0.33 5.72 0.3 2.4e-8 Body mass index; CRC cis rs72634258 0.554 rs4908699 chr1:7905274 G/A cg26816564 chr1:7831052 VAMP3 0.86 9.43 0.46 7.59e-19 Inflammatory bowel disease; CRC cis rs270601 0.770 rs10463891 chr5:131597392 C/T cg04518342 chr5:131593106 PDLIM4 -0.55 -10.4 -0.5 4.33e-22 Acylcarnitine levels; CRC cis rs2836974 0.644 rs11088471 chr21:40699313 A/G cg06238570 chr21:40685208 BRWD1 -0.83 -13.0 -0.58 1.9e-31 Cognitive function; CRC cis rs736408 0.511 rs12637632 chr3:52708073 A/T cg05573699 chr3:52720067 GNL3;PBRM1 -0.46 -6.53 -0.34 2.55e-10 Bipolar disorder; CRC trans rs800082 1.000 rs12637885 chr3:144291254 G/T cg24215973 chr2:240111563 HDAC4 -0.51 -6.91 -0.36 2.56e-11 Smoking behavior; CRC cis rs6598955 0.671 rs12116908 chr1:26587918 G/A cg04990556 chr1:26633338 UBXN11 0.56 6.02 0.32 4.53e-9 Obesity-related traits; CRC cis rs2836974 0.932 rs6517526 chr21:40581530 T/C cg17971929 chr21:40555470 PSMG1 0.83 11.93 0.55 1.67e-27 Cognitive function; CRC cis rs9733 0.596 rs12086472 chr1:150697710 G/A cg10589385 chr1:150898437 SETDB1 0.28 5.96 0.31 6.66e-9 Tonsillectomy; CRC cis rs11971779 0.618 rs6943788 chr7:139087697 C/T cg23387468 chr7:139079360 LUC7L2 0.41 7.04 0.36 1.14e-11 Diisocyanate-induced asthma; CRC cis rs6679356 0.789 rs6695348 chr1:67827016 T/C cg24364144 chr1:67875067 SERBP1 0.43 6.61 0.34 1.55e-10 Primary biliary cholangitis; CRC cis rs1387259 0.839 rs7487682 chr12:48579665 A/C cg21466736 chr12:48725269 NA 0.5 7.75 0.39 1.12e-13 Obstructive sleep apnea trait (apnea hypopnea index); CRC cis rs4713118 0.869 rs9366700 chr6:27696951 C/T cg15786705 chr6:28176104 NA 0.54 7.62 0.39 2.72e-13 Parkinson's disease; CRC cis rs372883 0.648 rs4817279 chr21:30638285 T/C cg24692254 chr21:30365293 RNF160 -0.63 -9.41 -0.46 8.77e-19 Pancreatic cancer; CRC cis rs9322193 0.962 rs2342764 chr6:150156204 G/A cg05861140 chr6:150128134 PCMT1 -0.37 -5.71 -0.3 2.49e-8 Lung cancer; CRC cis rs9649213 0.593 rs6970801 chr7:97925240 T/C cg21770322 chr7:97807741 LMTK2 0.5 8.23 0.41 4.49e-15 Prostate cancer (SNP x SNP interaction); CRC cis rs6867032 0.958 rs4975795 chr5:2015390 G/A cg26168224 chr5:2018326 NA 0.99 18.35 0.71 2.67e-52 Gut microbiome composition (winter); CRC cis rs7618501 0.521 rs2883059 chr3:49902160 C/T cg24110177 chr3:50126178 RBM5 0.59 8.89 0.44 4.13e-17 Intelligence (multi-trait analysis); CRC cis rs6860806 0.507 rs2631362 chr5:131707293 A/G cg09877947 chr5:131593287 PDLIM4 -0.45 -7.27 -0.37 2.72e-12 Breast cancer; CRC cis rs2579500 0.807 rs6753926 chr2:97298949 T/C cg23100626 chr2:96804247 ASTL -0.23 -5.65 -0.3 3.54e-8 Eosinophil counts;Eosinophil percentage of white cells; CRC trans rs11098499 0.865 rs10032158 chr4:120391632 C/T cg25214090 chr10:38739885 LOC399744 0.66 10.6 0.5 9.01e-23 Corneal astigmatism; CRC cis rs4356975 0.522 rs7679184 chr4:69965930 C/G cg25583503 chr4:69962676 UGT2B7 -0.32 -5.8 -0.3 1.55e-8 Obesity-related traits; CRC cis rs7731657 0.537 rs3962196 chr5:130372512 A/T cg08523029 chr5:130500466 HINT1 -0.45 -5.95 -0.31 6.73e-9 Fasting plasma glucose; CRC cis rs1552244 0.935 rs7652190 chr3:10105150 G/A cg10729496 chr3:10149963 C3orf24 0.58 7.52 0.38 5.23e-13 Alzheimer's disease; CRC cis rs34779708 0.966 rs1057108 chr10:35484949 T/G cg03585969 chr10:35415529 CREM 0.54 7.32 0.37 1.95e-12 Inflammatory bowel disease;Crohn's disease; CRC cis rs7945705 0.875 rs4929914 chr11:8824388 C/T cg14711859 chr11:8959438 ASCL3 0.35 5.65 0.3 3.43e-8 Hemoglobin concentration; CRC cis rs2836974 0.644 rs11088472 chr21:40699376 A/C cg11890956 chr21:40555474 PSMG1 -0.83 -13.53 -0.6 1.8e-33 Cognitive function; CRC cis rs56114371 0.777 rs200481 chr6:27773832 A/T cg26958806 chr6:27640298 NA 0.63 5.69 0.3 2.78e-8 Breast cancer; CRC cis rs11098499 0.913 rs13126596 chr4:120140729 A/G cg09307838 chr4:120376055 NA 0.59 8.79 0.44 8.47e-17 Corneal astigmatism; CRC cis rs806795 0.525 rs12661552 chr6:26265200 G/A cg13736514 chr6:26305472 NA -0.47 -7.68 -0.39 1.89e-13 Mosquito bite size; CRC cis rs5753618 0.561 rs737887 chr22:31696615 A/G cg22777020 chr22:31556080 RNF185 -0.53 -6.04 -0.32 4.08e-9 Colorectal cancer; CRC cis rs7089973 0.872 rs10490908 chr10:116616162 T/C cg23260525 chr10:116636907 FAM160B1 0.31 6.73 0.35 7.51e-11 Bipolar disorder or attention deficit hyperactivity disorder; CRC cis rs853679 0.517 rs1947862 chr6:28105196 C/T cg02631126 chr6:28058918 ZSCAN12L1 0.29 5.87 0.31 1.05e-8 Depression; CRC trans rs11148252 0.595 rs4884522 chr13:53053768 C/A cg18335740 chr13:41363409 SLC25A15 0.75 13.69 0.6 4.57e-34 Lewy body disease; CRC trans rs2303319 0.504 rs961421 chr2:162626099 G/C cg03774468 chr3:140950104 ACPL2 -0.65 -6.07 -0.32 3.46e-9 Cognitive function; CRC cis rs71403859 0.502 rs7195767 chr16:71464943 A/G cg08717414 chr16:71523259 ZNF19 -0.85 -8.97 -0.44 2.22e-17 Post bronchodilator FEV1; CRC cis rs6840360 0.606 rs2709813 chr4:152357444 T/C cg09659197 chr4:152720779 NA 0.34 6.66 0.34 1.14e-10 Intelligence (multi-trait analysis); CRC trans rs116095464 0.614 rs10061564 chr5:271329 T/C cg00938859 chr5:1591904 SDHAP3 0.72 7.72 0.39 1.43e-13 Breast cancer; CRC trans rs2303319 0.504 rs56009150 chr2:162598582 T/C cg04551154 chr10:95462393 C10orf4 -0.75 -6.36 -0.33 6.93e-10 Cognitive function; CRC cis rs1580019 0.922 rs1376289 chr7:32486980 C/G cg06627557 chr7:32535165 LSM5;AVL9 -0.82 -12.4 -0.56 3.04e-29 Cognitive ability; CRC trans rs800082 1.000 rs800082 chr3:144340205 A/G cg24215973 chr2:240111563 HDAC4 0.51 6.94 0.36 2.07e-11 Smoking behavior; CRC cis rs9322817 0.583 rs9391226 chr6:105158405 T/C cg02098413 chr6:105308735 HACE1 -0.42 -8.21 -0.41 5.1e-15 Thyroid stimulating hormone; CRC cis rs1862618 0.613 rs252889 chr5:56227069 C/A cg24531977 chr5:56204891 C5orf35 -0.69 -10.44 -0.5 3.23e-22 Initial pursuit acceleration; CRC cis rs907683 0.570 rs3755056 chr2:220281016 T/A cg15015639 chr2:220282977 DES 0.4 6.56 0.34 2.08e-10 Resting heart rate; CRC cis rs738322 0.967 rs4380 chr22:38569529 T/C cg25457927 chr22:38595422 NA -0.36 -7.46 -0.38 7.58e-13 Cutaneous nevi; CRC cis rs801193 1.000 rs10252765 chr7:66228732 C/G cg11764359 chr7:65958608 NA 0.51 7.67 0.39 1.9e-13 Aortic root size; CRC cis rs4731207 0.596 rs6466973 chr7:124605426 G/A cg23710748 chr7:124431027 NA -0.38 -6.08 -0.32 3.35e-9 Cutaneous malignant melanoma; CRC cis rs78707713 0.592 rs3829182 chr10:71251384 A/G cg12610070 chr10:71211762 TSPAN15 -0.4 -7.14 -0.37 5.96e-12 Venous thromboembolism; CRC cis rs7586879 0.658 rs7563204 chr2:25125075 T/G cg22495460 chr2:25135724 ADCY3 -0.87 -17.16 -0.69 1.36e-47 Body mass index; CRC cis rs2836974 0.897 rs8133146 chr21:40614298 T/C cg11644478 chr21:40555479 PSMG1 0.79 12.04 0.55 6.34e-28 Cognitive function; CRC cis rs6502050 0.835 rs6502077 chr17:80122966 G/C cg19223190 chr17:80058835 NA 0.39 6.23 0.32 1.43e-9 Life satisfaction; CRC cis rs13118159 0.801 rs1128427 chr4:1330759 T/C cg20887711 chr4:1340912 KIAA1530 0.44 6.05 0.32 3.94e-9 Longevity; CRC cis rs7666738 0.830 rs4699588 chr4:98973789 A/G cg17366294 chr4:99064904 C4orf37 0.44 7.44 0.38 8.98e-13 Colonoscopy-negative controls vs population controls; CRC cis rs919433 0.783 rs3097383 chr2:198236887 A/G cg10820045 chr2:198174542 NA 0.45 7.89 0.4 4.58e-14 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC cis rs3008870 0.755 rs2208577 chr1:67513574 A/C cg08660285 chr1:67390436 MIER1;WDR78 0.61 8.59 0.43 3.44e-16 Lymphocyte percentage of white cells; CRC cis rs9359856 0.564 rs41273329 chr6:90393483 G/A cg13799429 chr6:90582589 CASP8AP2 -0.75 -7.78 -0.39 9.4e-14 Bipolar disorder; CRC cis rs2692947 0.655 rs4605406 chr2:96583735 A/C cg23100626 chr2:96804247 ASTL 0.28 7.23 0.37 3.38e-12 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; CRC cis rs1552244 1.000 rs9820598 chr3:10117912 C/G cg16606324 chr3:10149918 C3orf24 0.7 9.74 0.47 7.03e-20 Alzheimer's disease; CRC cis rs1707322 0.721 rs61784800 chr1:46178112 A/G cg06784218 chr1:46089804 CCDC17 -0.58 -10.52 -0.5 1.69e-22 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC trans rs916888 0.773 rs199534 chr17:44824213 T/G cg22433210 chr17:43662623 NA 1.01 10.19 0.49 2.29e-21 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs4290604 0.831 rs7608514 chr2:238023578 C/A cg23555395 chr2:238036564 NA -0.66 -6.67 -0.35 1.09e-10 Asthma; CRC cis rs929354 0.772 rs6967764 chr7:156994964 C/T cg05182265 chr7:156933206 UBE3C -0.76 -14.52 -0.62 3.01e-37 Body mass index; CRC cis rs7208859 0.623 rs11657777 chr17:29091785 T/C cg13385521 chr17:29058706 SUZ12P 0.73 8.4 0.42 1.39e-15 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs853679 0.882 rs9468300 chr6:28126840 C/T cg06470822 chr6:28175283 NA 0.81 6.57 0.34 2.03e-10 Depression; CRC cis rs875971 0.545 rs316316 chr7:65614257 C/T cg03233332 chr7:66118400 NA 0.45 6.3 0.33 9.62e-10 Aortic root size; CRC cis rs4380275 1.000 rs4359695 chr2:774214 G/C cg27237671 chr2:676223 TMEM18 -0.43 -6.18 -0.32 1.95e-9 Adverse response to chemotherapy (neutropenia/leucopenia) (doxorubicin); CRC cis rs6964587 0.655 rs6465351 chr7:91773213 T/C cg17063962 chr7:91808500 NA 0.61 9.8 0.48 4.47e-20 Breast cancer; CRC cis rs4243830 0.737 rs11122085 chr1:6597861 T/C cg22792644 chr1:6614718 TAS1R1;NOL9 0.8 8.69 0.43 1.7e-16 Body mass index; CRC cis rs10782582 0.586 rs1796813 chr1:76400403 G/A cg03433033 chr1:76189801 ACADM -0.42 -6.2 -0.32 1.68e-9 Daytime sleep phenotypes; CRC trans rs6703335 0.870 rs10803142 chr1:243598234 A/G cg04915425 chr11:47236385 DDB2 0.44 6.05 0.32 3.86e-9 Schizophrenia;Schizophrenia, schizoaffective disorder or bipolar disorder; CRC trans rs310501 0.843 rs515334 chr5:82901788 C/T cg26920327 chr19:41035836 SPTBN4 -0.39 -5.97 -0.31 6.28e-9 Major depressive disorder; CRC cis rs561341 1.000 rs527256 chr17:30321293 C/G cg00745463 chr17:30367425 LRRC37B -0.88 -9.71 -0.47 9.33e-20 Hip circumference adjusted for BMI; CRC cis rs1799949 1.000 rs33926631 chr17:41304463 T/C cg01879757 chr17:41196368 BRCA1 -0.44 -6.73 -0.35 7.33e-11 Menopause (age at onset); CRC cis rs4919694 1.000 rs112809537 chr10:104670346 C/T cg04362960 chr10:104952993 NT5C2 1.12 10.35 0.5 6.61e-22 Arsenic metabolism; CRC cis rs7647973 0.626 rs9835157 chr3:49797769 G/A cg03060546 chr3:49711283 APEH -0.65 -7.89 -0.4 4.56e-14 Menarche (age at onset); CRC cis rs4566357 0.615 rs10178260 chr2:227914458 G/T cg11843606 chr2:227700838 RHBDD1 -0.44 -6.97 -0.36 1.7e-11 Coronary artery disease; CRC trans rs4144743 0.759 rs67972765 chr17:45318326 G/A cg03564338 chr16:50585384 NKD1 0.54 6.07 0.32 3.56e-9 Body mass index; CRC trans rs7647973 0.588 rs62262675 chr3:49673662 A/G cg21659725 chr3:3221576 CRBN 0.6 6.12 0.32 2.63e-9 Menarche (age at onset); CRC cis rs6088580 0.524 rs1321306 chr20:33266379 T/A cg08999081 chr20:33150536 PIGU -0.38 -5.69 -0.3 2.77e-8 Glomerular filtration rate (creatinine); CRC cis rs3018066 0.831 rs6533237 chr4:106954292 T/C cg01869342 chr4:106983673 TBCK 0.38 5.86 0.31 1.15e-8 Cancer; CRC cis rs801193 1.000 rs3800812 chr7:66223461 T/C cg25985355 chr7:65971099 NA -0.32 -5.61 -0.3 4.26e-8 Aortic root size; CRC cis rs9309711 0.666 rs11127430 chr2:3485242 G/C cg15541040 chr2:3486749 NA -0.52 -8.23 -0.41 4.52e-15 Neurofibrillary tangles; CRC cis rs1552244 1.000 rs61077902 chr3:10126153 T/G cg08888203 chr3:10149979 C3orf24 0.72 10.21 0.49 1.87e-21 Alzheimer's disease; CRC cis rs2688608 0.618 rs28553894 chr10:75489843 C/A cg23231163 chr10:75533350 FUT11 -0.37 -5.64 -0.3 3.64e-8 Inflammatory bowel disease; CRC cis rs4853012 0.941 rs4852329 chr2:74354544 A/G cg01017244 chr2:74357527 NA 0.75 9.4 0.46 9.37e-19 Gestational age at birth (maternal effect); CRC trans rs4276421 0.869 rs1351720 chr5:45561903 G/A cg04793272 chr11:119020941 ABCG4 -0.38 -6.1 -0.32 3.03e-9 P wave duration; CRC cis rs1401999 0.724 rs1016752 chr3:183665062 C/G cg20387954 chr3:183756860 HTR3D -0.44 -7.02 -0.36 1.28e-11 Anterior chamber depth; CRC cis rs2404602 0.735 rs11632222 chr15:76712927 C/G cg23625390 chr15:77176239 SCAPER -0.83 -12.41 -0.56 2.76e-29 Blood metabolite levels; CRC cis rs4253772 0.530 rs6008623 chr22:46710024 G/A cg09491104 chr22:46646882 C22orf40 -0.43 -5.83 -0.31 1.34e-8 LDL cholesterol;Cholesterol, total; CRC trans rs3942852 0.759 rs905475 chr11:48149755 C/T cg15704280 chr7:45808275 SEPT13 -0.6 -7.58 -0.39 3.65e-13 Acute lymphoblastic leukemia (childhood); CRC cis rs6499129 0.867 rs8056770 chr16:67416730 A/C cg26727032 chr16:67993705 SLC12A4 -0.6 -7.29 -0.37 2.37e-12 Waist-to-hip ratio adjusted for body mass index; CRC cis rs597539 0.690 rs552517 chr11:68625286 T/G cg04772025 chr11:68637568 NA 0.53 8.26 0.41 3.71e-15 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs10883723 0.810 rs6584504 chr10:104253507 T/C cg04362960 chr10:104952993 NT5C2 -0.43 -6.1 -0.32 2.92e-9 Allergic disease (asthma, hay fever or eczema); CRC cis rs853679 0.542 rs9380063 chr6:28137853 A/G cg18032046 chr6:28092343 ZSCAN16 -0.51 -5.93 -0.31 7.47e-9 Depression; CRC cis rs9443645 0.836 rs9352676 chr6:79629999 A/G cg05283184 chr6:79620031 NA -0.57 -9.14 -0.45 6.54e-18 Intelligence (multi-trait analysis); CRC cis rs2243480 1.000 rs10807702 chr7:65767843 C/T cg12463550 chr7:65579703 CRCP 0.64 5.88 0.31 9.83e-9 Diabetic kidney disease; CRC cis rs9549367 0.789 rs9549699 chr13:113878263 T/A cg00898013 chr13:113819073 PROZ -0.45 -6.73 -0.35 7.71e-11 Platelet distribution width; CRC trans rs2727020 0.521 rs10839285 chr11:49496852 T/G cg03929089 chr4:120376271 NA 0.73 10.11 0.49 4.1e-21 Coronary artery disease; CRC cis rs1832871 0.672 rs9457345 chr6:158743098 A/G cg07165851 chr6:158734300 TULP4 0.63 7.98 0.4 2.48e-14 Height; CRC cis rs4561483 0.549 rs154149 chr16:11956118 T/A cg08843971 chr16:11963173 GSPT1 -0.5 -7.7 -0.39 1.64e-13 Testicular germ cell tumor; CRC cis rs34172651 0.917 rs6497760 chr16:24806535 G/A cg00339695 chr16:24857497 SLC5A11 0.29 6.54 0.34 2.41e-10 Intelligence (multi-trait analysis); CRC cis rs4731207 0.698 rs6961292 chr7:124503189 A/G cg23710748 chr7:124431027 NA -0.38 -6.08 -0.32 3.42e-9 Cutaneous malignant melanoma; CRC cis rs7107174 0.892 rs10899487 chr11:78085474 G/A cg02023728 chr11:77925099 USP35 0.48 7.2 0.37 4.06e-12 Testicular germ cell tumor; CRC cis rs568617 0.953 rs583887 chr11:65644027 T/C cg19792802 chr11:65647270 CTSW -0.5 -7.55 -0.38 4.23e-13 Crohn's disease; CRC cis rs4665809 0.590 rs6730310 chr2:26419470 C/G cg26119090 chr2:26468346 HADHA;HADHB -1.06 -14.97 -0.64 5.39e-39 Gut microbiome composition (summer); CRC cis rs7119 0.717 rs11631274 chr15:77816431 A/T cg10437265 chr15:77819839 NA 0.69 12.74 0.57 1.76e-30 Type 2 diabetes; CRC cis rs3806843 0.735 rs801189 chr5:140063091 A/G cg19875535 chr5:140030758 IK -0.64 -10.73 -0.51 3.05e-23 Depressive symptoms (multi-trait analysis); CRC cis rs875971 0.660 rs2013222 chr7:66035936 C/G cg18876405 chr7:65276391 NA -0.61 -11.31 -0.53 2.89e-25 Aortic root size; CRC cis rs9527 0.569 rs78193706 chr10:104780564 T/C cg04362960 chr10:104952993 NT5C2 0.6 8.48 0.42 7.93e-16 Arsenic metabolism; CRC cis rs7617773 0.817 rs11710861 chr3:48297560 C/T cg11946769 chr3:48343235 NME6 0.63 8.63 0.43 2.64e-16 Coronary artery disease; CRC cis rs2836974 0.627 rs7278985 chr21:40653767 C/T cg11644478 chr21:40555479 PSMG1 -0.7 -11.4 -0.53 1.35e-25 Cognitive function; CRC cis rs11958404 0.789 rs72818145 chr5:157476552 G/C cg05962755 chr5:157440814 NA 1.0 12.64 0.57 4.01e-30 IgG glycosylation; CRC cis rs9303280 0.517 rs12939566 chr17:38038390 A/T cg11212589 chr17:38028394 ZPBP2 0.43 8.03 0.4 1.71e-14 Self-reported allergy; CRC cis rs736408 0.522 rs11716747 chr3:52748857 C/T cg11645453 chr3:52864694 ITIH4 0.37 6.53 0.34 2.57e-10 Bipolar disorder; CRC cis rs853679 1.000 rs1778511 chr6:28229411 G/A cg15845792 chr6:28175446 NA -0.61 -6.27 -0.33 1.14e-9 Depression; CRC cis rs7618501 0.602 rs2071207 chr3:50159844 T/C cg24110177 chr3:50126178 RBM5 0.52 8.14 0.41 8.26e-15 Intelligence (multi-trait analysis); CRC cis rs1862618 0.853 rs252902 chr5:56116085 A/G cg24531977 chr5:56204891 C5orf35 -0.79 -10.82 -0.51 1.56e-23 Initial pursuit acceleration; CRC cis rs10504229 0.511 rs75967910 chr8:58024231 C/G cg22535103 chr8:58192502 C8orf71 -0.68 -7.36 -0.38 1.49e-12 Developmental language disorder (linguistic errors); CRC cis rs6460942 0.591 rs6945587 chr7:12356992 G/A cg06484146 chr7:12443880 VWDE -0.55 -5.68 -0.3 3.02e-8 Coronary artery disease; CRC cis rs9640161 0.711 rs3800781 chr7:150027324 T/A cg13722127 chr7:150037890 RARRES2 0.5 7.96 0.4 2.84e-14 Blood protein levels;Circulating chemerin levels; CRC cis rs67311347 1.000 rs28871903 chr3:40511094 T/G cg24209194 chr3:40518798 ZNF619 0.41 5.71 0.3 2.47e-8 Renal cell carcinoma; CRC cis rs896854 0.631 rs10097617 chr8:95961626 T/C cg16049864 chr8:95962084 TP53INP1 -0.67 -12.5 -0.57 1.38e-29 Type 2 diabetes; CRC cis rs2811415 0.597 rs11721156 chr3:127796627 C/T cg13719885 chr3:127795394 NA -0.39 -5.86 -0.31 1.12e-8 Lung function (FEV1/FVC); CRC cis rs801193 0.569 rs3846973 chr7:66120035 T/C cg18876405 chr7:65276391 NA -0.5 -8.05 -0.41 1.5e-14 Aortic root size; CRC cis rs4474465 0.915 rs7128449 chr11:78206760 G/A cg27205649 chr11:78285834 NARS2 0.47 5.79 0.3 1.61e-8 Alzheimer's disease (survival time); CRC cis rs6076065 0.723 rs2249943 chr20:23378098 A/G cg11657817 chr20:23433608 CST11 0.45 6.61 0.34 1.55e-10 Facial morphology (factor 15, philtrum width); CRC cis rs9807989 0.507 rs6706002 chr2:103006104 A/G cg03938978 chr2:103052716 IL18RAP 0.59 10.18 0.49 2.53e-21 Asthma; CRC cis rs727505 1.000 rs1541416 chr7:124450345 T/C cg23710748 chr7:124431027 NA -0.69 -12.29 -0.56 8.25e-29 Lewy body disease; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg13478031 chr18:47808184 MBD1 0.45 6.2 0.32 1.64e-9 Anxiety disorder; CRC trans rs7267979 0.966 rs6037097 chr20:25347221 C/T cg17903999 chr18:56338584 MALT1 -0.41 -6.96 -0.36 1.81e-11 Liver enzyme levels (alkaline phosphatase); CRC cis rs910316 1.000 rs8003506 chr14:75586288 A/C cg03030879 chr14:75389066 RPS6KL1 0.49 7.53 0.38 4.88e-13 Height; CRC cis rs832540 0.931 rs33319 chr5:56206675 C/A cg20203395 chr5:56204925 C5orf35 -0.4 -5.63 -0.3 3.83e-8 Coronary artery disease; CRC cis rs8103278 0.507 rs3745802 chr19:46271177 G/T cg20908204 chr19:46285434 DMPK 0.34 7.61 0.39 2.82e-13 Coronary artery disease; CRC trans rs28643277 0.671 rs10906921 chr10:15555056 T/C cg18315834 chr14:64909119 MTHFD1 0.41 6.02 0.31 4.67e-9 Periodontitis (CDC/AAP); CRC cis rs798766 0.903 rs798726 chr4:1685211 C/T cg21505886 chr4:1724428 TMEM129;TACC3 0.4 5.75 0.3 1.99e-8 Bladder cancer;Urinary bladder cancer; CRC cis rs6748734 0.894 rs4675869 chr2:241827696 A/G cg07537917 chr2:241836409 C2orf54 -0.22 -6.17 -0.32 1.95e-9 Urinary metabolites; CRC cis rs230203 0.506 rs6070027 chr20:55780898 C/T cg13236649 chr20:55835020 BMP7 -0.38 -5.75 -0.3 1.99e-8 Monobrow; CRC cis rs611744 0.608 rs1448152 chr8:109278249 C/T cg18478394 chr8:109455254 TTC35 0.38 5.8 0.3 1.55e-8 Dupuytren's disease; CRC cis rs7945705 0.818 rs2653613 chr11:8879105 C/T cg21881798 chr11:8931708 C11orf17;ST5 -0.72 -12.57 -0.57 7.46e-30 Hemoglobin concentration; CRC trans rs656319 0.559 rs17689007 chr8:9974824 G/A cg08975724 chr8:8085496 FLJ10661 -0.42 -6.12 -0.32 2.59e-9 Myopia (pathological); CRC trans rs3733585 0.674 rs7375643 chr4:9955239 A/G cg26043149 chr18:55253948 FECH -0.53 -8.28 -0.42 3.04e-15 Cleft plate (environmental tobacco smoke interaction); CRC cis rs7085104 0.572 rs284860 chr10:104572963 T/C cg04362960 chr10:104952993 NT5C2 -0.55 -8.13 -0.41 8.67e-15 Immature fraction of reticulocytes;Schizophrenia; CRC cis rs7591163 0.883 rs16824023 chr2:228720877 G/A cg14329157 chr2:228736135 WDR69 -0.42 -6.17 -0.32 2.05e-9 Blood pressure; CRC cis rs4789294 0.806 rs9896887 chr17:74444059 G/A cg06840243 chr17:74442338 UBE2O 0.43 6.13 0.32 2.51e-9 Lymphocyte percentage of white cells; CRC cis rs66569888 0.538 rs56291108 chr2:106757143 G/A cg16099169 chr2:106886729 NA -0.37 -5.66 -0.3 3.29e-8 Facial morphology (factor 23); CRC cis rs4713118 0.513 rs149945 chr6:28002853 T/C cg15845792 chr6:28175446 NA 0.73 10.85 0.51 1.19e-23 Parkinson's disease; CRC cis rs1005277 0.528 rs2057228 chr10:38515766 T/C cg03665457 chr10:38645376 HSD17B7P2 -0.42 -5.96 -0.31 6.58e-9 Extrinsic epigenetic age acceleration; CRC cis rs34779708 0.966 rs12260130 chr10:35467671 C/T cg03585969 chr10:35415529 CREM 0.55 7.49 0.38 6.45e-13 Inflammatory bowel disease;Crohn's disease; CRC cis rs9660180 1.000 rs3737628 chr1:1722932 C/T cg23982607 chr1:1823379 GNB1 -0.87 -15.97 -0.66 6.42e-43 Body mass index; CRC cis rs3008870 1.000 rs2985822 chr1:67404910 T/G cg08660285 chr1:67390436 MIER1;WDR78 1.0 14.52 0.62 2.96e-37 Lymphocyte percentage of white cells; CRC cis rs116095464 0.558 rs6555052 chr5:224268 G/A cg22496380 chr5:211416 CCDC127 -0.84 -9.73 -0.47 7.72e-20 Breast cancer; CRC cis rs939574 1.000 rs56927225 chr2:220100922 A/G cg00496455 chr2:220118770 TUBA4A;TUBA4B 0.89 8.98 0.44 2.2e-17 Platelet distribution width; CRC trans rs2303319 0.504 rs62189053 chr2:162624324 G/A cg03774468 chr3:140950104 ACPL2 -0.65 -6.07 -0.32 3.46e-9 Cognitive function; CRC cis rs9457247 0.602 rs17615336 chr6:167506734 A/G cg07741184 chr6:167504864 NA 0.49 8.28 0.42 3.19e-15 Crohn's disease; CRC cis rs17376456 0.504 rs7702649 chr5:93065149 C/A cg25358565 chr5:93447407 FAM172A 0.62 7.31 0.37 2.02e-12 Diabetic retinopathy; CRC cis rs3733585 0.673 rs4580649 chr4:9948461 G/A cg00071950 chr4:10020882 SLC2A9 -0.54 -9.37 -0.46 1.24e-18 Cleft plate (environmental tobacco smoke interaction); CRC cis rs6831352 0.918 rs17218560 chr4:100060794 C/T cg12011299 chr4:100065546 ADH4 0.47 8.84 0.44 6.01e-17 Alcohol dependence; CRC cis rs673253 0.520 rs3791034 chr1:44145130 A/G cg10881128 chr1:44031826 PTPRF 0.24 5.82 0.31 1.42e-8 Intelligence (multi-trait analysis); CRC cis rs35771425 0.619 rs7538812 chr1:211442186 A/G cg25617285 chr1:211431773 RCOR3 -0.4 -5.74 -0.3 2.2e-8 Educational attainment (years of education); CRC cis rs172166 0.543 rs1150691 chr6:28168033 A/G cg15786705 chr6:28176104 NA 0.51 7.44 0.38 8.81e-13 Cardiac Troponin-T levels; CRC cis rs7552404 0.727 rs12093623 chr1:76256232 T/G cg10523679 chr1:76189770 ACADM 0.72 9.29 0.46 2.15e-18 Blood metabolite levels;Acylcarnitine levels; CRC cis rs3924048 0.559 rs4075303 chr1:12626593 C/G cg00291366 chr1:12616550 NA 0.55 9.76 0.47 6.14e-20 Optic cup area; CRC cis rs7639513 0.767 rs13060705 chr3:12710016 C/A cg23032965 chr3:12705835 RAF1 0.64 9.84 0.48 3.37e-20 Itch intensity from mosquito bite; CRC cis rs4478858 0.684 rs16865957 chr1:31753353 G/A cg00250761 chr1:31883323 NA -0.44 -8.59 -0.43 3.52e-16 Alcohol dependence; CRC cis rs853679 0.542 rs2295594 chr6:28053097 G/A cg06470822 chr6:28175283 NA 0.98 13.22 0.59 2.69e-32 Depression; CRC cis rs854765 0.583 rs9912895 chr17:17826020 C/T cg16928487 chr17:17741425 SREBF1 0.55 10.37 0.5 5.42e-22 Total body bone mineral density; CRC cis rs2878628 0.596 rs57039206 chr3:52758570 T/A cg05573699 chr3:52720067 GNL3;PBRM1 -0.48 -7.02 -0.36 1.27e-11 Intelligence (multi-trait analysis); CRC cis rs11122272 0.735 rs2474633 chr1:231486989 A/C cg06096015 chr1:231504339 EGLN1 0.42 6.45 0.34 3.97e-10 Hemoglobin concentration; CRC cis rs6541297 1.000 rs11122405 chr1:230282997 C/A cg20703242 chr1:230279135 GALNT2 0.51 7.71 0.39 1.52e-13 Coronary artery disease; CRC cis rs28386778 0.897 rs3785572 chr17:61829989 C/T cg23090583 chr17:61904693 PSMC5;FTSJ3 1.04 20.64 0.75 2.54e-61 Prudent dietary pattern; CRC cis rs12048904 0.512 rs932798 chr1:101249355 G/C cg15686842 chr1:101360669 SLC30A7;EXTL2 -0.56 -7.63 -0.39 2.55e-13 Multiple sclerosis; CRC cis rs6088590 0.735 rs6060003 chr20:33294945 T/C cg24642439 chr20:33292090 TP53INP2 0.44 7.5 0.38 6.01e-13 Coronary artery disease; CRC cis rs11098499 0.863 rs10018280 chr4:120478139 T/G cg24375607 chr4:120327624 NA 0.49 7.3 0.37 2.12e-12 Corneal astigmatism; CRC cis rs644799 1.000 rs516551 chr11:95588626 C/T cg25478527 chr11:95522999 CEP57;FAM76B 0.53 8.0 0.4 2.08e-14 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC trans rs4650994 0.525 rs4650996 chr1:178517365 A/G cg05059571 chr16:84539110 KIAA1609 -0.64 -8.87 -0.44 4.81e-17 HDL cholesterol levels;HDL cholesterol; CRC cis rs3733585 0.605 rs4697926 chr4:10124567 G/T cg00071950 chr4:10020882 SLC2A9 0.51 8.15 0.41 7.48e-15 Cleft plate (environmental tobacco smoke interaction); CRC cis rs1524976 1.000 rs1524976 chr3:65486388 A/G cg16238336 chr3:65465873 MAGI1 0.5 6.43 0.33 4.59e-10 PR interval; CRC cis rs10883723 0.518 rs10786679 chr10:104315667 C/T cg11453585 chr10:104263688 ACTR1A;SUFU 0.73 11.04 0.52 2.63e-24 Allergic disease (asthma, hay fever or eczema); CRC cis rs10504229 1.000 rs17216711 chr8:58170856 T/C cg24829409 chr8:58192753 C8orf71 -0.68 -11.34 -0.53 2.27e-25 Developmental language disorder (linguistic errors); CRC trans rs6703335 0.870 rs10803142 chr1:243598234 A/G cg03856714 chr2:96658020 NA 0.46 6.49 0.34 3.15e-10 Schizophrenia;Schizophrenia, schizoaffective disorder or bipolar disorder; CRC cis rs7659604 0.676 rs4516739 chr4:122699741 G/T cg19748678 chr4:122722346 EXOSC9 0.68 10.83 0.51 1.36e-23 Type 2 diabetes; CRC cis rs17767392 0.918 rs17767499 chr14:71867275 T/C cg13720639 chr14:72061746 SIPA1L1 -0.54 -6.84 -0.35 3.96e-11 Mitral valve prolapse; CRC cis rs1552244 1.000 rs34179822 chr3:10140017 A/G cg13047869 chr3:10149882 C3orf24 0.51 7.34 0.37 1.72e-12 Alzheimer's disease; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg12551166 chr16:85645228 KIAA0182 0.46 6.7 0.35 9.32e-11 Intelligence (multi-trait analysis); CRC cis rs6582630 0.537 rs7310749 chr12:38400472 C/T cg26384229 chr12:38710491 ALG10B 0.7 9.81 0.48 4.41e-20 Drug-induced liver injury (flucloxacillin); CRC cis rs3820068 0.705 rs41486146 chr1:15900517 A/G cg27534772 chr1:16042836 PLEKHM2 -0.42 -6.65 -0.34 1.19e-10 Systolic blood pressure; CRC cis rs7208859 0.623 rs1061342 chr17:29114463 G/A cg13385521 chr17:29058706 SUZ12P 0.73 8.38 0.42 1.53e-15 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC trans rs2797160 1.000 rs984040 chr6:126021277 A/G cg05039488 chr6:79577232 IRAK1BP1 0.5 7.39 0.38 1.24e-12 Endometrial cancer; CRC trans rs7615952 1.000 rs7615952 chr3:125649403 A/C cg00769240 chr8:12517080 NA 0.51 6.4 0.33 5.42e-10 Blood pressure (smoking interaction); CRC trans rs7302981 0.667 rs7308692 chr12:50627654 C/T cg21483700 chr19:12943593 RTBDN 0.37 5.99 0.31 5.61e-9 Systolic blood pressure; CRC cis rs9303280 0.901 rs9303277 chr17:37976469 C/T cg00129232 chr17:37814104 STARD3 -0.41 -6.54 -0.34 2.4e-10 Self-reported allergy; CRC cis rs2832191 0.720 rs2832194 chr21:30494250 T/C cg08807101 chr21:30365312 RNF160 -0.63 -9.93 -0.48 1.74e-20 Dental caries; CRC cis rs7638909 0.512 rs7645178 chr3:38597558 A/G cg01465620 chr3:38496096 LOC100128640;ACVR2B -0.51 -7.29 -0.37 2.27e-12 Electrocardiographic conduction measures; CRC cis rs116095464 0.558 rs10043002 chr5:226753 G/A cg22496380 chr5:211416 CCDC127 -0.86 -10.03 -0.48 7.61e-21 Breast cancer; CRC cis rs2898681 0.519 rs6554057 chr4:53730147 A/T cg00791764 chr4:53727839 RASL11B 0.51 6.9 0.36 2.73e-11 Optic nerve measurement (cup area); CRC trans rs60843830 1.000 rs60484953 chr2:221560 G/A cg11347411 chr7:150020925 ACTR3C;LRRC61 0.6 9.11 0.45 8.3e-18 Spherical equivalent (joint analysis main effects and education interaction); CRC cis rs6840360 0.593 rs10222925 chr4:152690215 A/G cg22705602 chr4:152727874 NA -0.35 -5.88 -0.31 9.94e-9 Intelligence (multi-trait analysis); CRC cis rs4665809 1.000 rs1030730 chr2:26284143 T/C cg26119090 chr2:26468346 HADHA;HADHB -0.67 -8.27 -0.41 3.39e-15 Gut microbiome composition (summer); CRC cis rs62244186 0.566 rs3762636 chr3:44854563 A/G cg10263370 chr3:44754102 ZNF502 -0.36 -6.14 -0.32 2.39e-9 Depressive symptoms; CRC cis rs7412746 0.658 rs10888397 chr1:150886752 A/G cg15448220 chr1:150897856 SETDB1 -0.48 -6.99 -0.36 1.57e-11 Melanoma; CRC trans rs61931739 0.500 rs4436630 chr12:34394200 C/T cg26384229 chr12:38710491 ALG10B 0.61 9.02 0.45 1.59e-17 Morning vs. evening chronotype; CRC cis rs9549328 0.614 rs35299896 chr13:113617229 G/T cg08614441 chr13:113633676 MCF2L 0.4 7.08 0.36 8.76e-12 Systolic blood pressure; CRC cis rs11785693 0.862 rs62491169 chr8:4986425 C/A cg26367366 chr8:4980734 NA 0.87 10.47 0.5 2.44e-22 Neuroticism (multi-trait analysis);Neuroticism; CRC cis rs6960043 0.738 rs2358159 chr7:15054908 T/C cg19272540 chr7:15055459 NA 0.24 6.61 0.34 1.58e-10 Type 2 diabetes; CRC cis rs6988636 1.000 rs13260775 chr8:124190167 G/A cg27053337 chr8:124217698 FAM83A 0.43 6.59 0.34 1.74e-10 Urinary uromodulin levels; CRC trans rs61931739 0.534 rs7133262 chr12:34279444 G/A cg26384229 chr12:38710491 ALG10B 0.53 6.78 0.35 5.46e-11 Morning vs. evening chronotype; CRC cis rs10504229 0.683 rs55868006 chr8:58135703 C/T cg02290350 chr8:58132656 NA -0.58 -8.16 -0.41 7.29e-15 Developmental language disorder (linguistic errors); CRC trans rs853679 1.000 rs853678 chr6:28297313 T/A cg06606381 chr12:133084897 FBRSL1 -0.58 -6.11 -0.32 2.89e-9 Depression; CRC cis rs1862618 0.715 rs6866779 chr5:56090000 G/A cg12311346 chr5:56204834 C5orf35 -0.78 -10.11 -0.49 4.1e-21 Initial pursuit acceleration; CRC cis rs7769051 0.522 rs7762248 chr6:133105303 A/C cg22852734 chr6:133119734 C6orf192 0.81 6.72 0.35 7.89e-11 Type 2 diabetes nephropathy; CRC trans rs2727020 0.658 rs4980440 chr11:49386017 C/T cg03929089 chr4:120376271 NA -0.87 -15.87 -0.66 1.69e-42 Coronary artery disease; CRC cis rs6540556 0.723 rs12034758 chr1:209920545 G/A cg05527609 chr1:210001259 C1orf107 -0.54 -6.01 -0.31 5.06e-9 Red blood cell count; CRC cis rs12024301 0.557 rs12027675 chr1:183657048 G/A cg11505048 chr1:183622726 RGL1;APOBEC4 0.71 6.24 0.33 1.33e-9 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs1552244 1.000 rs6772315 chr3:10113644 G/A cg10729496 chr3:10149963 C3orf24 0.54 7.19 0.37 4.3e-12 Alzheimer's disease; CRC trans rs9467711 0.659 rs36162392 chr6:26569135 T/C cg06606381 chr12:133084897 FBRSL1 -1.07 -7.43 -0.38 9.5e-13 Autism spectrum disorder or schizophrenia; CRC cis rs3824347 0.804 rs4527947 chr9:77587202 T/A cg01251476 chr9:77566080 C9orf40 0.37 5.7 0.3 2.66e-8 Urinary magnesium-to-creatinine ratio; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg17687970 chr8:22462467 KIAA1967 0.38 7.21 0.37 3.76e-12 Liver disease severity in Alagille syndrome; CRC cis rs2120019 0.938 rs59094290 chr15:75308561 G/T cg17294928 chr15:75287854 SCAMP5 -0.8 -11.52 -0.54 4.88e-26 Blood trace element (Zn levels); CRC trans rs783540 0.934 rs783530 chr15:83266549 G/C cg18393722 chr15:85113863 UBE2QP1 -0.37 -6.26 -0.33 1.18e-9 Schizophrenia; CRC cis rs28386778 0.863 rs7221573 chr17:61859390 G/A cg23090583 chr17:61904693 PSMC5;FTSJ3 1.05 20.71 0.75 1.47e-61 Prudent dietary pattern; CRC cis rs9303401 0.646 rs7342863 chr17:57227010 G/A cg02118635 chr17:56770003 RAD51C;TEX14 0.44 6.78 0.35 5.53e-11 Cognitive test performance; CRC cis rs9796 0.870 rs72737704 chr15:41323575 C/G cg18705301 chr15:41695430 NDUFAF1 -0.36 -6.03 -0.32 4.34e-9 Menopause (age at onset); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg09448058 chr2:70521051 SNRPG 0.43 5.98 0.31 5.83e-9 Intelligence (multi-trait analysis); CRC cis rs4713118 0.513 rs156738 chr6:28014025 G/C cg02683197 chr6:28174875 NA 0.62 8.4 0.42 1.32e-15 Parkinson's disease; CRC cis rs10782582 0.593 rs11801414 chr1:76124517 G/A cg10523679 chr1:76189770 ACADM -0.4 -5.66 -0.3 3.28e-8 Daytime sleep phenotypes; CRC cis rs172166 0.516 rs2791333 chr6:28111114 A/G cg25164649 chr6:28176230 NA 0.47 6.9 0.36 2.75e-11 Cardiac Troponin-T levels; CRC cis rs7591163 0.959 rs11685995 chr2:228722008 T/C cg14329157 chr2:228736135 WDR69 -0.44 -6.15 -0.32 2.27e-9 Blood pressure; CRC cis rs733592 0.894 rs886589 chr12:48477197 C/T cg21466736 chr12:48725269 NA 0.47 7.37 0.38 1.39e-12 Plateletcrit; CRC cis rs3785574 0.927 rs2854183 chr17:61968002 C/T cg06601766 chr17:61851465 DDX42;CCDC47 0.59 8.2 0.41 5.53e-15 Height; CRC cis rs9303401 0.659 rs7210432 chr17:56668170 C/T cg10487724 chr17:56770010 TEX14;RAD51C 0.79 9.55 0.47 3.04e-19 Cognitive test performance; CRC cis rs2836974 0.931 rs13625 chr21:40669083 G/T cg06238570 chr21:40685208 BRWD1 0.79 10.97 0.52 4.45e-24 Cognitive function; CRC cis rs896854 0.654 rs1453377 chr8:95969947 C/T cg23172400 chr8:95962367 TP53INP1 -0.45 -7.75 -0.39 1.14e-13 Type 2 diabetes; CRC cis rs7086803 1.000 rs7075510 chr10:114501509 C/T cg03281572 chr10:114502318 VTI1A 0.75 6.34 0.33 7.77e-10 Lung cancer; CRC cis rs6860806 0.507 rs2631372 chr5:131703578 C/G cg02033258 chr5:131593261 PDLIM4 0.38 6.4 0.33 5.28e-10 Breast cancer; CRC cis rs6088590 0.561 rs6059932 chr20:33175466 C/T cg24642439 chr20:33292090 TP53INP2 0.4 6.89 0.36 2.78e-11 Coronary artery disease; CRC cis rs7605827 0.930 rs11898971 chr2:15613678 C/T cg19274914 chr2:15703543 NA -0.4 -5.97 -0.31 6.28e-9 Educational attainment (years of education); CRC cis rs28386778 0.897 rs2584640 chr17:61863488 C/T cg06601766 chr17:61851465 DDX42;CCDC47 0.44 6.04 0.32 4.16e-9 Prudent dietary pattern; CRC cis rs10924970 0.934 rs4288584 chr1:235436631 C/T cg26050004 chr1:235667680 B3GALNT2 0.4 5.94 0.31 7.23e-9 Asthma; CRC trans rs2303319 0.504 rs62189048 chr2:162613494 G/C cg11326919 chr17:43324904 LOC100133991 -0.64 -5.97 -0.31 5.99e-9 Cognitive function; CRC cis rs1577917 1.000 rs35385043 chr6:86648546 T/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.51 -6.88 -0.35 3.08e-11 Response to antipsychotic treatment; CRC cis rs9399135 0.933 rs28384512 chr6:135376232 C/T cg24558204 chr6:135376177 HBS1L 0.49 7.64 0.39 2.39e-13 Red blood cell count; CRC cis rs2252790 0.899 rs1204854 chr6:116580896 T/A cg18764771 chr6:116381957 FRK -0.21 -5.67 -0.3 3.15e-8 Fast beta electroencephalogram; CRC cis rs7107174 1.000 rs4245459 chr11:78065959 T/G cg02023728 chr11:77925099 USP35 0.5 7.56 0.38 3.92e-13 Testicular germ cell tumor; CRC cis rs10857712 0.950 rs10857711 chr10:135224059 G/A cg19623624 chr10:135278901 LOC619207 -0.37 -6.09 -0.32 3.15e-9 Systemic lupus erythematosus; CRC cis rs3806843 0.966 rs7737424 chr5:140146345 C/T cg19875535 chr5:140030758 IK 0.55 8.8 0.44 7.81e-17 Depressive symptoms (multi-trait analysis); CRC cis rs2075371 0.897 rs10488428 chr7:133997560 C/T cg02659138 chr7:134003124 SLC35B4 0.39 6.48 0.34 3.36e-10 Mean platelet volume; CRC cis rs2286885 1.000 rs10733678 chr9:129242280 G/A cg15282417 chr9:129245246 FAM125B 0.44 8.11 0.41 1.01e-14 Intraocular pressure; CRC trans rs7647973 0.593 rs9870755 chr3:49809841 A/G cg21659725 chr3:3221576 CRBN -0.63 -7.01 -0.36 1.39e-11 Menarche (age at onset); CRC cis rs951366 0.617 rs823075 chr1:205774897 C/T cg14893161 chr1:205819251 PM20D1 1.05 20.17 0.74 1.78e-59 Menarche (age at onset); CRC cis rs17152411 0.895 rs7906592 chr10:126627861 C/G cg07906193 chr10:126599966 NA 0.62 6.89 0.36 2.79e-11 Height; CRC trans rs1376359 0.636 rs12753266 chr1:103120262 G/A cg16220183 chr17:56609687 SEPT4 -0.48 -6.64 -0.34 1.28e-10 QRS duration in Tripanosoma cruzi seropositivity; CRC cis rs7552404 0.727 rs5745390 chr1:76306591 A/C cg22875332 chr1:76189707 ACADM 0.59 7.69 0.39 1.72e-13 Blood metabolite levels;Acylcarnitine levels; CRC cis rs796364 1.000 rs769949 chr2:200729558 A/G cg23649088 chr2:200775458 C2orf69 0.55 6.01 0.31 4.84e-9 Schizophrenia; CRC trans rs1455244 0.700 rs7229302 chr18:11508904 G/T cg21403771 chr7:131241396 PODXL 0.38 6.24 0.33 1.35e-9 Schizophrenia; CRC cis rs1552244 0.554 rs4488814 chr3:10002400 C/T cg13047869 chr3:10149882 C3orf24 -0.38 -6.02 -0.32 4.55e-9 Alzheimer's disease; CRC cis rs2153535 0.541 rs6923558 chr6:8461467 T/G cg07606381 chr6:8435919 SLC35B3 0.67 10.71 0.51 3.63e-23 Motion sickness; CRC cis rs2204008 0.837 rs7974888 chr12:37945215 A/G cg26384229 chr12:38710491 ALG10B 0.65 9.0 0.44 1.81e-17 Bladder cancer; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg12068969 chr15:77362720 TSPAN3 0.43 5.96 0.31 6.42e-9 Response to antipsychotic treatment; CRC cis rs2836974 0.897 rs1571709 chr21:40553980 T/C cg06238570 chr21:40685208 BRWD1 0.75 10.48 0.5 2.33e-22 Cognitive function; CRC cis rs10504229 1.000 rs66870803 chr8:58180022 G/C cg01721255 chr8:58191610 C8orf71 0.49 6.17 0.32 2e-9 Developmental language disorder (linguistic errors); CRC cis rs7584330 0.666 rs72620816 chr2:238353604 C/T cg14458575 chr2:238380390 NA 0.9 15.94 0.66 8.83e-43 Prostate cancer; CRC cis rs7605827 0.930 rs2241236 chr2:15655480 A/G cg19274914 chr2:15703543 NA 0.4 6.0 0.31 5.16e-9 Educational attainment (years of education); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg24120822 chr15:69113128 ANP32A 0.4 6.04 0.32 4.28e-9 Liver disease severity in Alagille syndrome; CRC cis rs35110281 0.667 rs7282122 chr21:45082365 G/A cg01579765 chr21:45077557 HSF2BP -0.36 -6.9 -0.36 2.75e-11 Mean corpuscular volume; CRC cis rs9910055 0.762 rs1135215 chr17:42253519 T/C cg13607699 chr17:42295918 UBTF 0.48 6.39 0.33 5.6e-10 Total body bone mineral density; CRC cis rs9611565 0.512 rs9611672 chr22:42209922 A/G cg03806693 chr22:41940476 POLR3H -1.09 -13.34 -0.59 9.89e-33 Vitiligo; CRC cis rs763121 0.853 rs5750630 chr22:38985818 A/C cg06544989 chr22:39130855 UNC84B 0.42 6.16 0.32 2.09e-9 Menopause (age at onset); CRC cis rs6717918 0.887 rs6746834 chr2:233158817 C/T ch.2.233013039R chr2:233304795 NA -0.5 -7.03 -0.36 1.2e-11 Height; CRC cis rs7809950 1.000 rs2237672 chr7:107131563 A/C cg23024343 chr7:107201750 COG5 -0.6 -8.59 -0.43 3.52e-16 Coronary artery disease; CRC cis rs1707322 0.721 rs10890346 chr1:46223892 C/T cg03146154 chr1:46216737 IPP -0.65 -9.32 -0.46 1.69e-18 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs9527 0.590 rs1475642 chr10:104546183 C/T cg04362960 chr10:104952993 NT5C2 -0.58 -6.73 -0.35 7.7e-11 Arsenic metabolism; CRC cis rs9372498 0.505 rs17080456 chr6:118985938 G/C cg18833306 chr6:118973337 C6orf204 0.47 6.03 0.32 4.32e-9 Diastolic blood pressure; CRC cis rs9937943 0.616 rs12923487 chr16:74644112 G/T cg01733217 chr16:74700730 RFWD3 0.7 7.38 0.38 1.35e-12 Neutrophil percentage of white cells; CRC cis rs4713118 0.955 rs9468200 chr6:27683063 T/A cg21204522 chr6:27730016 NA -0.41 -5.63 -0.3 3.86e-8 Parkinson's disease; CRC cis rs9926296 0.605 rs6500449 chr16:89856393 T/C cg04287289 chr16:89883240 FANCA 0.81 14.38 0.62 1.05e-36 Vitiligo; CRC cis rs6088580 0.634 rs6059824 chr20:33014543 T/C cg08999081 chr20:33150536 PIGU 0.62 11.52 0.54 5.06e-26 Glomerular filtration rate (creatinine); CRC cis rs7937682 0.564 rs10891277 chr11:111373103 A/G cg09085632 chr11:111637200 PPP2R1B 0.48 6.48 0.34 3.43e-10 Primary sclerosing cholangitis; CRC cis rs10046574 0.731 rs10267977 chr7:135159392 G/A cg27474649 chr7:135195673 CNOT4 0.69 5.7 0.3 2.61e-8 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs736408 0.609 rs2230534 chr3:52802402 A/C cg10802521 chr3:52805072 NEK4 -0.59 -8.89 -0.44 4.24e-17 Bipolar disorder; CRC cis rs763014 0.932 rs2269560 chr16:682442 A/C cg02475695 chr16:616220 NHLRC4 0.45 7.28 0.37 2.42e-12 Height; CRC cis rs2243480 1.000 rs2533288 chr7:66056711 C/G cg18252515 chr7:66147081 NA -1.29 -15.37 -0.65 1.43e-40 Diabetic kidney disease; CRC cis rs9296095 0.607 rs9469485 chr6:33514093 C/T cg14003231 chr6:33640908 ITPR3 0.46 7.01 0.36 1.36e-11 Platelet count; CRC cis rs79839061 0.520 rs6842808 chr4:906903 C/T cg14530993 chr4:882597 GAK 0.78 7.72 0.39 1.38e-13 Intelligence (multi-trait analysis); CRC cis rs9916302 0.808 rs12947281 chr17:37652210 G/T cg03013999 chr17:37608204 MED1 0.45 6.91 0.36 2.54e-11 Glomerular filtration rate (creatinine); CRC cis rs8180040 1.000 rs811115 chr3:47322133 C/T cg27129171 chr3:47204927 SETD2 0.57 8.88 0.44 4.4e-17 Colorectal cancer; CRC cis rs1915146 0.967 rs7086481 chr10:126844523 A/T cg00406319 chr10:126851303 NA -0.41 -6.16 -0.32 2.07e-9 Menarche (age at onset); CRC trans rs478304 0.593 rs2236682 chr11:65480090 G/T cg17712092 chr4:129076599 LARP1B -0.43 -6.23 -0.32 1.42e-9 Acne (severe); CRC cis rs11651000 0.625 rs4794063 chr17:45804494 C/T cg24803719 chr17:45855879 NA -0.29 -5.9 -0.31 8.95e-9 IgG glycosylation; CRC cis rs3087591 0.960 rs11080146 chr17:29578724 C/T cg24425628 chr17:29625626 OMG;NF1 -0.85 -16.19 -0.67 8.91e-44 Hip circumference; CRC cis rs1799949 0.965 rs9911630 chr17:41188342 A/G cg19454999 chr17:41278357 BRCA1;NBR2 0.39 5.96 0.31 6.34e-9 Menopause (age at onset); CRC trans rs10506458 0.834 rs58821476 chr12:63389425 T/C cg03429785 chr15:59498649 MYO1E;LDHAL6B -1.46 -21.13 -0.76 3.29e-63 Hemostatic factors and hematological phenotypes; CRC trans rs1005277 0.579 rs2505237 chr10:38438898 T/G cg11292332 chr7:45801988 SEPT13 -0.34 -6.16 -0.32 2.12e-9 Extrinsic epigenetic age acceleration; CRC cis rs1448094 0.520 rs12304244 chr12:86272823 C/T cg25456477 chr12:86230367 RASSF9 0.33 5.67 0.3 3.16e-8 Major depressive disorder; CRC cis rs2692947 0.695 rs12464148 chr2:96596710 G/C cg23100626 chr2:96804247 ASTL 0.25 6.92 0.36 2.31e-11 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; CRC trans rs10982213 0.830 rs2274163 chr9:117188714 C/T cg15985338 chr7:6048868 PMS2;AIMP2 0.4 6.19 0.32 1.82e-9 Interleukin-6 levels; CRC cis rs908922 0.702 rs569232 chr1:152526643 A/G cg23254163 chr1:152506842 NA 0.44 8.41 0.42 1.27e-15 Hair morphology; CRC cis rs7605827 0.780 rs2287279 chr2:15667778 G/A cg19274914 chr2:15703543 NA 0.39 5.83 0.31 1.32e-8 Educational attainment (years of education); CRC cis rs56011263 0.687 rs4690293 chr4:706101 A/G cg20735989 chr4:730612 PCGF3 -0.47 -5.9 -0.31 8.87e-9 White blood cell count; CRC cis rs35306767 0.953 rs11253517 chr10:970524 A/G cg20503657 chr10:835505 NA -0.82 -10.34 -0.5 6.68e-22 Eosinophil percentage of granulocytes; CRC cis rs7677751 0.806 rs1800813 chr4:55094467 G/A cg13615338 chr4:55094005 PDGFRA 0.4 5.68 0.3 2.99e-8 Corneal astigmatism; CRC cis rs10256972 0.552 rs2949192 chr7:1203841 C/T cg18765753 chr7:1198926 ZFAND2A -0.41 -7.21 -0.37 3.78e-12 Longevity;Endometriosis; CRC cis rs1129187 0.755 rs9471986 chr6:42944127 A/G cg10862848 chr6:42927986 GNMT -0.39 -9.22 -0.45 3.57e-18 Alzheimer's disease in APOE e4+ carriers; CRC cis rs1153858 1.000 rs4775906 chr15:45638294 C/T cg21132104 chr15:45694354 SPATA5L1 0.58 8.6 0.43 3.24e-16 Homoarginine levels; CRC cis rs870825 0.616 rs12512839 chr4:185610347 G/A cg04058563 chr4:185651563 MLF1IP 0.73 8.03 0.4 1.71e-14 Blood protein levels; CRC cis rs1018836 0.884 rs13279263 chr8:91648780 T/C cg16814680 chr8:91681699 NA -0.7 -10.64 -0.51 6.45e-23 Ejection fraction in Tripanosoma cruzi seropositivity; CRC cis rs10870270 0.830 rs10781571 chr10:133774316 G/C cg17892150 chr10:133769511 PPP2R2D -0.75 -11.05 -0.52 2.38e-24 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; CRC cis rs7586879 0.789 rs13035239 chr2:25134000 T/A cg04586622 chr2:25135609 ADCY3 -0.58 -9.66 -0.47 1.35e-19 Body mass index; CRC cis rs4237845 0.837 rs7954957 chr12:58299250 C/T cg02175503 chr12:58329896 NA 0.62 8.97 0.44 2.25e-17 Intelligence (multi-trait analysis); CRC cis rs12143943 0.966 rs2369246 chr1:204567762 C/T cg17419461 chr1:204415978 PIK3C2B 0.4 6.04 0.32 4.28e-9 Cognitive performance; CRC cis rs769267 0.965 rs2269873 chr19:19392401 T/C cg20644253 chr19:19431407 KIAA0892;SF4 0.43 5.97 0.31 6e-9 Tonsillectomy; CRC cis rs3733585 0.631 rs4697925 chr4:10124330 G/C cg11266682 chr4:10021025 SLC2A9 -0.44 -7.95 -0.4 2.97e-14 Cleft plate (environmental tobacco smoke interaction); CRC cis rs7552404 0.727 rs5745427 chr1:76332637 C/A cg10523679 chr1:76189770 ACADM -0.65 -8.49 -0.42 7.35e-16 Blood metabolite levels;Acylcarnitine levels; CRC trans rs3780486 0.846 rs10113903 chr9:33122645 C/G cg04842962 chr6:43655489 MRPS18A -1.14 -24.62 -0.81 1.25e-76 IgG glycosylation; CRC cis rs1179624 0.639 rs13233152 chr7:75272055 C/T cg05145297 chr7:75264568 HIP1 0.61 8.39 0.42 1.42e-15 Age-related nuclear cataracts; CRC cis rs853679 0.517 rs9380059 chr6:28132358 A/C cg15845792 chr6:28175446 NA 1.04 13.89 0.61 7.67e-35 Depression; CRC cis rs72781680 0.898 rs12622290 chr2:23979894 C/G cg08917208 chr2:24149416 ATAD2B 0.86 8.42 0.42 1.16e-15 Lymphocyte counts; CRC cis rs9814567 0.712 rs9838621 chr3:134332319 C/T cg06109529 chr3:134205091 CEP63;ANAPC13 -0.67 -9.58 -0.47 2.53e-19 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs10089 0.953 rs6879970 chr5:127387178 A/G cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.75 10.85 0.51 1.22e-23 Ileal carcinoids; CRC cis rs6918586 0.658 rs198822 chr6:26123539 G/C cg18357526 chr6:26021779 HIST1H4A -0.5 -7.61 -0.39 2.97e-13 Schizophrenia; CRC cis rs898097 0.691 rs7222773 chr17:80907283 A/G cg17346650 chr17:80929145 B3GNTL1 0.33 5.7 0.3 2.62e-8 Breast cancer; CRC cis rs3087591 1.000 rs7226006 chr17:29650656 A/G cg24425628 chr17:29625626 OMG;NF1 -0.77 -14.22 -0.62 4.06e-36 Hip circumference; CRC cis rs3806843 0.864 rs2531343 chr5:140129346 A/G cg16607685 chr5:140181889 PCDHA2;PCDHA1;PCDHA3 0.26 5.93 0.31 7.73e-9 Depressive symptoms (multi-trait analysis); CRC cis rs9381040 0.610 rs2268191 chr6:41027653 G/C cg04346459 chr6:41068666 NFYA;LOC221442 -0.41 -6.17 -0.32 2.04e-9 Alzheimer's disease (late onset); CRC cis rs17270561 0.609 rs3922699 chr6:25734969 A/G cg17691542 chr6:26056736 HIST1H1C 0.73 9.26 0.45 2.71e-18 Iron status biomarkers; CRC cis rs1065852 0.526 rs2097562 chr22:42389500 T/C cg22189786 chr22:42395067 WBP2NL 0.44 6.44 0.33 4.33e-10 Response to serotonin reuptake inhibitors in major depressive disorder (plasma drug and metabolite levels); CRC cis rs9649213 0.593 rs13246868 chr7:97986453 T/C cg21770322 chr7:97807741 LMTK2 0.53 8.62 0.43 2.78e-16 Prostate cancer (SNP x SNP interaction); CRC cis rs9322193 1.000 rs9767077 chr6:150109615 T/A cg00933542 chr6:150070202 PCMT1 0.28 5.63 0.3 3.86e-8 Lung cancer; CRC cis rs7647973 1.000 rs10155014 chr3:49432321 C/T cg20833759 chr3:49053208 WDR6;DALRD3 0.57 8.85 0.44 5.5e-17 Menarche (age at onset); CRC cis rs3996993 0.809 rs1984728 chr6:52677591 C/T cg20803780 chr6:52668592 GSTA1 0.35 6.24 0.33 1.37e-9 Hemoglobin concentration; CRC cis rs2832191 0.671 rs2832213 chr21:30512914 A/G cg24692254 chr21:30365293 RNF160 -0.56 -8.25 -0.41 3.76e-15 Dental caries; CRC cis rs9435341 0.896 rs1623927 chr1:107596120 T/C cg11070056 chr1:107600091 PRMT6 -0.4 -5.74 -0.3 2.12e-8 Facial morphology (factor 21, depth of nasal alae); CRC cis rs1862618 0.853 rs1862619 chr5:56098256 T/A cg12311346 chr5:56204834 C5orf35 -0.73 -9.48 -0.46 5.09e-19 Initial pursuit acceleration; CRC cis rs3733346 0.505 rs11734449 chr4:921733 C/A cg20916646 chr4:852691 GAK 0.54 7.4 0.38 1.18e-12 Sjögren's syndrome; CRC cis rs10540 1.000 rs67912009 chr11:495057 G/T cg03576123 chr11:487126 PTDSS2 -0.9 -9.83 -0.48 3.65e-20 Body mass index; CRC cis rs9649213 0.574 rs6961790 chr7:98007993 C/G cg21770322 chr7:97807741 LMTK2 0.51 8.39 0.42 1.44e-15 Prostate cancer (SNP x SNP interaction); CRC trans rs9291683 0.551 rs2276961 chr4:10022981 C/T cg26043149 chr18:55253948 FECH 0.51 7.85 0.4 5.82e-14 Bone mineral density; CRC cis rs5750830 0.649 rs2413590 chr22:39790191 G/C cg25956985 chr22:39795188 MAP3K7IP1 -0.47 -6.56 -0.34 2.07e-10 Intelligence (multi-trait analysis); CRC cis rs6499255 0.951 rs11639947 chr16:69646122 C/T cg04110750 chr16:69646130 NFAT5 -0.57 -7.74 -0.39 1.24e-13 IgE levels; CRC cis rs7072216 0.763 rs7914401 chr10:100163928 A/G cg26618903 chr10:100175079 PYROXD2 -0.51 -8.4 -0.42 1.4e-15 Metabolite levels; CRC cis rs4363385 0.720 rs6665527 chr1:152967009 C/A cg25856811 chr1:152973957 SPRR3 -0.27 -7.55 -0.38 4.33e-13 Inflammatory skin disease; CRC cis rs2153535 0.580 rs1335636 chr6:8465047 T/C cg07606381 chr6:8435919 SLC35B3 0.68 10.9 0.51 8.26e-24 Motion sickness; CRC cis rs3733585 0.699 rs7437120 chr4:9967683 T/A cg11266682 chr4:10021025 SLC2A9 -0.47 -9.51 -0.46 4.17e-19 Cleft plate (environmental tobacco smoke interaction); CRC cis rs1799949 1.000 rs8077486 chr17:41212805 C/T cg07153921 chr17:41440717 NA -0.37 -5.69 -0.3 2.8e-8 Menopause (age at onset); CRC cis rs11958404 0.932 rs59246968 chr5:157418180 T/C cg05962755 chr5:157440814 NA 0.76 10.43 0.5 3.33e-22 IgG glycosylation; CRC cis rs4713118 0.621 rs4713134 chr6:28034121 T/C cg12963246 chr6:28129442 ZNF389 0.47 5.77 0.3 1.84e-8 Parkinson's disease; CRC cis rs10504229 1.000 rs66731170 chr8:58187895 C/G cg24829409 chr8:58192753 C8orf71 -0.68 -11.34 -0.53 2.27e-25 Developmental language disorder (linguistic errors); CRC cis rs12681287 0.640 rs34794500 chr8:87449995 G/A cg27223183 chr8:87520930 FAM82B -0.52 -7.44 -0.38 8.7e-13 Caudate activity during reward; CRC cis rs270601 0.837 rs367805 chr5:131701279 T/C cg27615366 chr5:131592974 PDLIM4 0.32 5.75 0.3 2e-8 Acylcarnitine levels; CRC cis rs2153535 0.580 rs4639392 chr6:8446547 A/G cg07606381 chr6:8435919 SLC35B3 0.68 10.85 0.51 1.22e-23 Motion sickness; CRC trans rs1814175 0.527 rs3974435 chr11:49619533 G/A cg11707556 chr5:10655725 ANKRD33B -0.42 -6.89 -0.36 2.9e-11 Height; CRC cis rs4689388 0.750 rs10001190 chr4:6284633 C/T cg00701064 chr4:6280414 WFS1 -0.58 -8.97 -0.44 2.27e-17 Type 2 diabetes and other traits;Type 2 diabetes; CRC cis rs11098699 0.821 rs11935129 chr4:124207106 T/A cg09941581 chr4:124220074 SPATA5 0.4 5.87 0.31 1.08e-8 Mosquito bite size; CRC cis rs7614311 0.681 rs6796317 chr3:63927739 A/G cg22134162 chr3:63841271 THOC7 -0.54 -5.83 -0.31 1.3e-8 Lung function (FVC);Lung function (FEV1); CRC cis rs6502050 0.835 rs9900128 chr17:80087920 A/T cg19223190 chr17:80058835 NA 0.39 6.16 0.32 2.12e-9 Life satisfaction; CRC cis rs4820294 1.000 rs4820294 chr22:38071043 G/A cg21798802 chr22:38057573 PDXP 0.46 7.45 0.38 8.16e-13 Fat distribution (HIV); CRC cis rs7618915 0.501 rs2109634 chr3:52752075 T/G cg10802521 chr3:52805072 NEK4 -0.58 -9.05 -0.45 1.31e-17 Bipolar disorder; CRC cis rs853679 0.517 rs9393888 chr6:28059217 G/C cg15845792 chr6:28175446 NA 0.98 13.03 0.58 1.45e-31 Depression; CRC cis rs7772486 0.754 rs1055212 chr6:146058315 A/T cg23711669 chr6:146136114 FBXO30 -0.74 -12.72 -0.57 2.07e-30 Lobe attachment (rater-scored or self-reported); CRC cis rs7098414 0.511 rs7899513 chr10:82150559 G/A cg00277334 chr10:82204260 NA -0.47 -7.58 -0.39 3.48e-13 Post bronchodilator FEV1; CRC cis rs55823223 0.680 rs57287238 chr17:73850940 T/C cg08125733 chr17:73851984 WBP2 1.01 13.49 0.6 2.68e-33 Psoriasis; CRC trans rs10838801 1 rs10838801 chr11:48098280 G/A cg15704280 chr7:45808275 SEPT13 -0.68 -9.57 -0.47 2.73e-19 Height; CRC cis rs12893668 0.572 rs35011804 chr14:104151400 C/T cg24130564 chr14:104152367 KLC1 -0.43 -5.74 -0.3 2.19e-8 Reticulocyte count; CRC trans rs925098 0.577 rs2724470 chr4:17996046 A/G cg24003225 chr3:184870891 C3orf70 -0.43 -6.31 -0.33 8.83e-10 Birth weight;Height; CRC cis rs1580019 0.922 rs34545272 chr7:32460630 C/T cg06627557 chr7:32535165 LSM5;AVL9 0.84 13.53 0.6 1.88e-33 Cognitive ability; CRC cis rs1007738 0.542 rs4752970 chr11:47208982 A/G cg19486271 chr11:47235900 DDB2 -0.44 -6.07 -0.32 3.43e-9 Bone mineral density (hip); CRC cis rs950169 0.610 rs34529571 chr15:84691807 A/G cg17507749 chr15:85114479 UBE2QP1 0.67 8.94 0.44 2.9e-17 Schizophrenia; CRC cis rs35306767 0.714 rs12767171 chr10:1084491 A/G cg26597838 chr10:835615 NA 0.67 9.0 0.44 1.79e-17 Eosinophil percentage of granulocytes; CRC cis rs1322512 1.000 rs7744715 chr6:152949026 G/A cg03415253 chr6:152958462 SYNE1 -0.42 -6.43 -0.33 4.53e-10 Tonometry; CRC cis rs12142240 0.659 rs72677591 chr1:46818219 T/G cg14993813 chr1:46806288 NSUN4 -0.48 -6.18 -0.32 1.87e-9 Menopause (age at onset); CRC cis rs924607 1.000 rs2455331 chr5:643593 T/C cg01605746 chr5:669925 TPPP 0.34 5.6 0.3 4.45e-8 Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia; CRC trans rs2303319 0.504 rs57419108 chr2:162311357 G/C cg19471553 chr17:41393123 NA -0.7 -6.07 -0.32 3.48e-9 Cognitive function; CRC cis rs4727027 0.840 rs12670633 chr7:148796707 G/A cg23583168 chr7:148888333 NA -0.89 -14.83 -0.63 1.87e-38 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC cis rs57221529 0.766 rs72706610 chr5:561111 G/A cg16447950 chr5:562315 NA -0.83 -11.29 -0.53 3.31e-25 Lung disease severity in cystic fibrosis; CRC cis rs9372498 0.536 rs62424172 chr6:118777533 C/A cg01339444 chr6:118972232 C6orf204 0.54 6.02 0.32 4.65e-9 Diastolic blood pressure; CRC cis rs10504229 1.000 rs949848 chr8:58169125 A/G cg02290350 chr8:58132656 NA -0.42 -6.07 -0.32 3.57e-9 Developmental language disorder (linguistic errors); CRC cis rs7762018 0.882 rs4716342 chr6:170137959 A/G cg19338460 chr6:170058176 WDR27 -0.71 -7.74 -0.39 1.27e-13 Thiazide-induced adverse metabolic effects in hypertensive patients; CRC cis rs939584 0.867 rs34119520 chr2:632760 T/C cg03610516 chr2:642275 NA 0.42 5.65 0.3 3.49e-8 Body mass index; CRC cis rs10504229 0.683 rs7817188 chr8:58129549 C/T cg02290350 chr8:58132656 NA -0.58 -8.16 -0.41 7.29e-15 Developmental language disorder (linguistic errors); CRC cis rs2933343 0.729 rs1680786 chr3:128644840 T/C cg11901034 chr3:128598214 ACAD9 -0.56 -8.15 -0.41 7.47e-15 IgG glycosylation; CRC cis rs6879260 1.000 rs7706951 chr5:179733407 C/T cg26918954 chr5:179728553 GFPT2 -0.42 -6.87 -0.35 3.29e-11 Height; CRC cis rs889312 0.500 rs252906 chr5:56119190 G/T cg03609598 chr5:56110824 MAP3K1 -0.41 -5.67 -0.3 3.13e-8 Breast cancer;Breast cancer (early onset); CRC cis rs6461049 0.638 rs1859993 chr7:2183702 A/G cg02951883 chr7:2050386 MAD1L1 -0.51 -8.24 -0.41 4.2e-15 Schizophrenia; CRC trans rs1814175 0.559 rs1818892 chr11:49863084 C/A cg03929089 chr4:120376271 NA -0.91 -15.93 -0.66 9.48e-43 Height; CRC cis rs6500602 0.855 rs1139652 chr16:4476089 T/C cg14951292 chr16:4525986 HMOX2;NMRAL1 0.57 7.53 0.38 5.05e-13 Schizophrenia; CRC cis rs35110281 0.693 rs11089093 chr21:45121161 C/T cg01579765 chr21:45077557 HSF2BP -0.35 -6.54 -0.34 2.3e-10 Mean corpuscular volume; CRC cis rs28386778 0.724 rs35092235 chr17:61944621 T/C cg22520471 chr17:61851767 DDX42;CCDC47 0.73 11.24 0.53 5.01e-25 Prudent dietary pattern; CRC cis rs3785574 0.962 rs2665799 chr17:61919723 A/G cg22520471 chr17:61851767 DDX42;CCDC47 0.46 6.34 0.33 7.7e-10 Height; CRC cis rs7408868 1.000 rs7408868 chr19:15285679 G/C cg14696996 chr19:15285081 NOTCH3 0.91 8.58 0.43 3.82e-16 Pulse pressure; CRC cis rs736801 0.808 rs72797306 chr5:131800750 G/C cg21138405 chr5:131827807 IRF1 -0.36 -6.21 -0.32 1.59e-9 Breast cancer;Mosquito bite size; CRC cis rs7811142 0.830 rs1063945 chr7:99930447 C/T cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.61 7.9 0.4 4.33e-14 Platelet count; CRC cis rs1949733 0.655 rs2631736 chr4:8478421 C/G cg11789530 chr4:8429930 ACOX3 -0.74 -10.96 -0.52 5.07e-24 Response to antineoplastic agents; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg22856972 chr6:134275178 TBPL1 0.43 6.56 0.34 2.06e-10 Response to antipsychotic treatment; CRC cis rs9467711 0.591 rs10484435 chr6:26031811 A/C cg16898833 chr6:26189333 HIST1H4D 0.74 6.39 0.33 5.72e-10 Autism spectrum disorder or schizophrenia; CRC trans rs10504229 1.000 rs61998259 chr8:58192290 T/C cg04077850 chr5:125800366 GRAMD3 0.37 6.27 0.33 1.15e-9 Developmental language disorder (linguistic errors); CRC cis rs1656402 1.000 rs1190440 chr2:233422274 G/A cg03852847 chr2:233439513 NA 0.45 7.71 0.39 1.54e-13 Non-small cell lung cancer (survival); CRC cis rs12188164 0.610 rs57433159 chr5:418725 C/T cg00976097 chr5:421733 AHRR -0.42 -5.78 -0.3 1.72e-8 Cystic fibrosis severity; CRC cis rs8060686 0.858 rs6499143 chr16:67874264 T/C cg26727032 chr16:67993705 SLC12A4 -0.73 -11.82 -0.55 4.12e-27 HDL cholesterol;Metabolic syndrome; CRC cis rs10089 1.000 rs72794401 chr5:127517626 C/T cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.74 9.58 0.47 2.52e-19 Ileal carcinoids; CRC cis rs1816752 1.000 rs1816752 chr13:24980949 A/G cg02811702 chr13:24901961 NA 0.46 6.32 0.33 8.48e-10 Obesity-related traits; CRC cis rs6062302 0.522 rs6090475 chr20:62245397 C/A cg06363034 chr20:62225388 GMEB2 -0.44 -6.8 -0.35 4.95e-11 Glioblastoma; CRC cis rs4664304 0.658 rs2667016 chr2:160868855 C/T cg03641300 chr2:160917029 PLA2R1 -0.39 -5.65 -0.3 3.46e-8 Crohn's disease;Inflammatory bowel disease; CRC cis rs73200209 0.912 rs57465027 chr12:116627026 G/C cg01776926 chr12:116560359 MED13L -0.48 -5.82 -0.31 1.43e-8 Total body bone mineral density; CRC cis rs6582630 0.638 rs1829584 chr12:38526299 G/T cg13010199 chr12:38710504 ALG10B -0.44 -6.35 -0.33 7.25e-10 Drug-induced liver injury (flucloxacillin); CRC cis rs7246760 1.000 rs7246772 chr19:9886283 C/T cg16876255 chr19:9731953 ZNF561 0.69 5.71 0.3 2.49e-8 Pursuit maintenance gain; CRC cis rs7659604 1.000 rs73844281 chr4:122664688 A/G cg19748678 chr4:122722346 EXOSC9 0.54 8.67 0.43 2.05e-16 Type 2 diabetes; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg05604720 chr8:90769698 RIPK2 0.47 6.94 0.36 2.14e-11 Intelligence (multi-trait analysis); CRC cis rs4713118 0.868 rs7756968 chr6:27734954 C/G cg02683197 chr6:28174875 NA 0.67 7.19 0.37 4.4e-12 Parkinson's disease; CRC cis rs11098499 0.955 rs35434465 chr4:120169378 C/G cg09307838 chr4:120376055 NA 0.65 9.9 0.48 2.18e-20 Corneal astigmatism; CRC cis rs4478858 0.735 rs12134484 chr1:31823741 G/A cg00250761 chr1:31883323 NA -0.44 -8.42 -0.42 1.2e-15 Alcohol dependence; CRC cis rs9341808 0.690 rs9448909 chr6:80909031 G/A cg08355045 chr6:80787529 NA 0.43 6.94 0.36 2.08e-11 Sitting height ratio; CRC cis rs4561483 0.551 rs1126889 chr16:12061910 C/G cg08843971 chr16:11963173 GSPT1 -0.45 -6.31 -0.33 8.96e-10 Testicular germ cell tumor; CRC cis rs2227564 0.830 rs2633322 chr10:75693932 T/C cg00564723 chr10:75632066 CAMK2G -0.3 -7.08 -0.36 8.83e-12 Crohn's disease;Inflammatory bowel disease; CRC cis rs992157 0.710 rs12612347 chr2:219057338 C/T cg00012203 chr2:219082015 ARPC2 -0.61 -10.0 -0.48 1e-20 Colorectal cancer; CRC cis rs7647973 1.000 rs3866330 chr3:49582994 T/C cg07636037 chr3:49044803 WDR6 0.67 8.43 0.42 1.09e-15 Menarche (age at onset); CRC cis rs6502050 0.799 rs4789673 chr17:80123218 T/C cg02741985 chr17:80059408 CCDC57 0.43 7.15 0.37 5.59e-12 Life satisfaction; CRC cis rs4555082 0.874 rs760270 chr14:105737785 A/G cg06808227 chr14:105710500 BRF1 -0.62 -8.75 -0.43 1.16e-16 Mean platelet volume;Platelet distribution width; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg15957017 chr4:71571214 RUFY3 0.38 6.18 0.32 1.92e-9 Liver disease severity in Alagille syndrome; CRC cis rs2153535 0.580 rs9505467 chr6:8520219 G/A cg21535247 chr6:8435926 SLC35B3 0.47 7.27 0.37 2.63e-12 Motion sickness; CRC cis rs9309711 0.666 rs11127430 chr2:3485242 G/C cg15506890 chr2:3487001 NA -0.53 -8.58 -0.43 3.92e-16 Neurofibrillary tangles; CRC cis rs6952808 0.601 rs3800882 chr7:2120758 G/A cg04267008 chr7:1944627 MAD1L1 -0.56 -8.05 -0.41 1.53e-14 Bipolar disorder and schizophrenia; CRC cis rs76878669 0.561 rs4244813 chr11:66129488 G/C cg24851651 chr11:66362959 CCS -0.38 -6.54 -0.34 2.3e-10 Educational attainment (years of education); CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg07791671 chr2:242255336 SEPT2;HDLBP 0.46 6.36 0.33 6.84e-10 Anxiety disorder; CRC cis rs769267 0.965 rs2023882 chr19:19405405 T/C cg03709012 chr19:19516395 GATAD2A 0.71 11.0 0.52 3.55e-24 Tonsillectomy; CRC cis rs12900413 0.603 rs12911871 chr15:90301429 T/C cg24249390 chr15:90295951 MESP1 -0.61 -9.28 -0.46 2.26e-18 Coronary artery aneurysm in Kawasaki disease; CRC cis rs972578 0.840 rs8138151 chr22:43386003 T/A cg01576275 chr22:43409880 NA -0.48 -7.66 -0.39 2.14e-13 Mean platelet volume; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg08207256 chr19:10828848 DNM2;MIR638 0.4 7.51 0.38 5.65e-13 Liver disease severity in Alagille syndrome; CRC cis rs2204008 0.774 rs3910796 chr12:38230660 G/T cg26384229 chr12:38710491 ALG10B 0.7 9.31 0.46 1.88e-18 Bladder cancer; CRC cis rs2204008 0.580 rs11520047 chr12:38051778 T/A cg26384229 chr12:38710491 ALG10B 0.69 9.17 0.45 5.4e-18 Bladder cancer; CRC cis rs611744 0.647 rs1457211 chr8:109261318 C/T cg21045802 chr8:109455806 TTC35 -0.4 -6.33 -0.33 8.15e-10 Dupuytren's disease; CRC cis rs2836950 0.545 rs4818001 chr21:40575088 T/C cg11890956 chr21:40555474 PSMG1 -0.68 -10.04 -0.48 7.38e-21 Menarche (age at onset); CRC cis rs35306767 0.761 rs11253560 chr10:1047226 T/G cg20503657 chr10:835505 NA 0.92 11.13 0.52 1.19e-24 Eosinophil percentage of granulocytes; CRC cis rs68170813 0.559 rs79778437 chr7:107004972 T/A cg02696742 chr7:106810147 HBP1 -0.5 -5.73 -0.3 2.31e-8 Coronary artery disease; CRC trans rs8073060 0.586 rs2011897 chr17:34054408 A/T cg19694781 chr19:47549865 TMEM160 1.07 14.64 0.63 1.04e-37 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg00762468 chr16:103568 POLR3K;SNRNP25 0.38 5.96 0.31 6.33e-9 Obesity-related traits; CRC cis rs2573652 0.722 rs12903458 chr15:100542673 T/G cg00587665 chr15:100533223 ADAMTS17 -0.36 -6.27 -0.33 1.13e-9 Height; CRC cis rs733592 1.000 rs733592 chr12:48429776 C/T cg24011408 chr12:48396354 COL2A1 -0.38 -5.68 -0.3 3.01e-8 Plateletcrit; CRC cis rs1552244 0.816 rs56271597 chr3:10042790 C/T cg16606324 chr3:10149918 C3orf24 0.64 8.31 0.42 2.59e-15 Alzheimer's disease; CRC cis rs765787 0.530 rs2554456 chr15:45521138 A/C cg24006582 chr15:45444508 DUOX1 -0.56 -8.42 -0.42 1.22e-15 Uric acid levels; CRC cis rs7043114 0.525 rs10761153 chr9:95130769 A/G cg14631576 chr9:95140430 CENPP -0.3 -5.63 -0.3 3.78e-8 Height; CRC cis rs10242455 0.702 rs45461000 chr7:99052710 A/G cg18809830 chr7:99032528 PTCD1 -1.14 -8.35 -0.42 1.92e-15 Blood metabolite levels; CRC cis rs6432018 1.000 rs3951115 chr2:9740561 T/C cg12832956 chr2:9616023 IAH1 -0.38 -5.75 -0.3 2.08e-8 Heart rate variability traits; CRC cis rs7258465 1.000 rs2278238 chr19:18576484 T/C cg06462663 chr19:18546047 ISYNA1 0.48 7.36 0.38 1.47e-12 Breast cancer; CRC cis rs2070677 1.000 rs743534 chr10:135349226 G/T cg16964102 chr10:135390573 NA -0.47 -6.45 -0.33 4.08e-10 Gout; CRC cis rs4731207 0.596 rs2402756 chr7:124579782 A/G cg23710748 chr7:124431027 NA -0.39 -6.12 -0.32 2.71e-9 Cutaneous malignant melanoma; CRC cis rs1799949 1.000 rs8176077 chr17:41276348 T/C cg25072359 chr17:41440525 NA 0.46 6.93 0.36 2.19e-11 Menopause (age at onset); CRC trans rs1814175 0.727 rs2140597 chr11:49873946 G/A cg11707556 chr5:10655725 ANKRD33B -0.42 -8.05 -0.41 1.48e-14 Height; CRC cis rs896854 0.654 rs6982393 chr8:95980708 T/C cg23172400 chr8:95962367 TP53INP1 -0.49 -8.25 -0.41 3.81e-15 Type 2 diabetes; CRC cis rs7119 0.717 rs8033654 chr15:77825250 T/C cg27398640 chr15:77910606 LINGO1 -0.44 -7.52 -0.38 5.19e-13 Type 2 diabetes; CRC cis rs1983170 0.736 rs13447495 chr1:91974965 A/G cg21854759 chr1:92012499 NA 0.52 6.0 0.31 5.25e-9 Eosinophil percentage of white cells; CRC cis rs365302 1.000 rs485368 chr6:159651361 C/G cg14500486 chr6:159655392 FNDC1 0.44 6.82 0.35 4.31e-11 Coronary heart disease; CRC cis rs6809651 0.524 rs4686728 chr3:185795333 C/T cg00760338 chr3:185826511 ETV5 0.7 9.17 0.45 5.13e-18 Body mass index in physically active individuals;Glomerular filtration rate (creatinine);Body mass index (joint analysis main effects and physical activity interaction);Body mass index;Body mass index in physically inactive individuals; CRC trans rs875971 0.660 rs2191268 chr7:66110224 C/T cg21024916 chr3:4535815 ITPR1 -0.35 -6.04 -0.32 4.28e-9 Aortic root size; CRC cis rs9393777 0.513 rs9295702 chr6:26634040 T/C cg12292205 chr6:26970375 C6orf41 -0.6 -6.75 -0.35 6.71e-11 Intelligence (multi-trait analysis); CRC cis rs6951245 1.000 rs11761941 chr7:1097183 G/A cg20603222 chr7:1096387 C7orf50;GPR146 -0.72 -8.66 -0.43 2.19e-16 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs62229266 0.693 rs2835264 chr21:37435965 C/T cg12218747 chr21:37451666 NA -0.37 -6.16 -0.32 2.11e-9 Mitral valve prolapse; CRC cis rs9911578 0.765 rs66954617 chr17:56999427 A/G cg12560992 chr17:57184187 TRIM37 0.92 17.22 0.69 8.3e-48 Intelligence (multi-trait analysis); CRC cis rs780096 0.506 rs2950834 chr2:27627366 G/A cg22903471 chr2:27725779 GCKR -0.38 -6.17 -0.32 2.03e-9 Total body bone mineral density; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg17008164 chr15:31507824 NA 0.4 6.92 0.36 2.43e-11 Liver disease severity in Alagille syndrome; CRC cis rs938554 0.784 rs7682751 chr4:9976294 A/G cg11266682 chr4:10021025 SLC2A9 0.35 5.64 0.3 3.62e-8 Blood metabolite levels; CRC cis rs9399135 0.935 rs6908681 chr6:135337733 A/G cg22676075 chr6:135203613 NA 0.4 6.25 0.33 1.27e-9 Red blood cell count; CRC cis rs9660992 0.649 rs12128229 chr1:205268014 C/A cg21643547 chr1:205240462 TMCC2 -0.43 -6.78 -0.35 5.71e-11 Mean corpuscular volume;Mean platelet volume; CRC cis rs6951245 0.872 rs77569514 chr7:1085508 G/A cg07217954 chr7:1067459 C7orf50 0.55 5.61 0.3 4.23e-8 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs4400599 1.000 rs4400599 chr1:154127100 A/G cg05139571 chr1:154127138 NUP210L 0.46 7.32 0.37 1.97e-12 Platelet distribution width; CRC cis rs2668423 0.501 rs502121 chr19:1387299 T/C cg02639931 chr19:1387894 NDUFS7 -0.7 -12.27 -0.56 9.65e-29 Nonalcoholic fatty liver disease; CRC cis rs2072510 0.966 rs1990611 chr12:96413984 G/A cg22491680 chr12:96389547 HAL -0.38 -5.95 -0.31 7.03e-9 Metabolite levels (small molecules and protein measures); CRC cis rs2062225 1.000 rs1157084 chr2:111755123 G/A cg11729679 chr2:111877065 BCL2L11 -0.56 -5.64 -0.3 3.67e-8 Monocyte count; CRC cis rs317689 0.513 rs529268 chr12:69687051 G/A cg20891283 chr12:69753455 YEATS4 0.7 11.31 0.53 2.78e-25 Response to diuretic therapy; CRC cis rs9549367 0.713 rs1755690 chr13:113824266 T/C cg24300038 chr13:113819356 PROZ 0.5 6.61 0.34 1.51e-10 Platelet distribution width; CRC cis rs873946 0.586 rs61862838 chr10:134572282 C/T cg26818010 chr10:134567672 INPP5A -0.7 -9.06 -0.45 1.17e-17 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CRC cis rs4713118 0.869 rs9283881 chr6:27715255 A/T cg20933634 chr6:27740509 NA 0.59 8.66 0.43 2.1e-16 Parkinson's disease; CRC cis rs4665809 1.000 rs10048683 chr2:26320519 C/T cg04944784 chr2:26401820 FAM59B -0.59 -7.55 -0.38 4.36e-13 Gut microbiome composition (summer); CRC cis rs921968 0.541 rs3755042 chr2:219317248 T/C cg02176678 chr2:219576539 TTLL4 -0.57 -9.12 -0.45 7.52e-18 Mean corpuscular hemoglobin concentration; CRC cis rs2281845 0.929 rs6413915 chr1:201091041 A/C cg01987224 chr1:201084466 NA -0.5 -9.56 -0.47 2.84e-19 Permanent tooth development; CRC trans rs10838798 0.504 rs10838852 chr11:48286256 C/T cg03929089 chr4:120376271 NA -0.47 -6.74 -0.35 7.08e-11 Height; CRC cis rs75804782 0.641 rs55844289 chr2:239323207 C/T cg18131467 chr2:239335373 ASB1 -0.7 -6.21 -0.32 1.56e-9 Morning vs. evening chronotype;Chronotype; CRC cis rs8058578 0.832 rs3812999 chr16:30773605 G/T cg02466173 chr16:30829666 NA -0.76 -12.15 -0.56 2.66e-28 Multiple myeloma; CRC cis rs7493 0.950 rs17880101 chr7:95031457 A/T cg21856205 chr7:94953877 PON1 -0.5 -6.45 -0.34 3.88e-10 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs9733 0.566 rs878471 chr1:150547747 G/A cg15448220 chr1:150897856 SETDB1 -0.4 -6.2 -0.32 1.64e-9 Tonsillectomy; CRC cis rs2239547 0.657 rs13072536 chr3:52861211 A/T cg11645453 chr3:52864694 ITIH4 0.62 11.22 0.53 5.75e-25 Schizophrenia; CRC cis rs2777491 0.957 rs8026197 chr15:41711447 C/T cg18705301 chr15:41695430 NDUFAF1 -0.73 -12.65 -0.57 3.59e-30 Ulcerative colitis; CRC cis rs10464366 0.746 rs6945402 chr7:39145385 A/T cg18850127 chr7:39170497 POU6F2 0.53 6.98 0.36 1.59e-11 IgG glycosylation; CRC cis rs6540556 0.608 rs2205985 chr1:209912100 A/G cg23920097 chr1:209922102 NA -0.45 -5.67 -0.3 3.2e-8 Red blood cell count; CRC trans rs6951245 1.000 rs11768761 chr7:1069807 A/G cg13565492 chr6:43139072 SRF -0.71 -7.31 -0.37 2.04e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs7212938 0.509 rs3893044 chr17:38103016 C/T cg17467752 chr17:38218738 THRA -0.42 -6.12 -0.32 2.72e-9 Asthma and hay fever; CRC cis rs2842992 0.789 rs2277072 chr6:160182845 A/G cg11366901 chr6:160182831 ACAT2 0.98 14.41 0.62 7.9e-37 Age-related macular degeneration (geographic atrophy); CRC trans rs7267979 0.966 rs2145126 chr20:25263648 G/A cg17903999 chr18:56338584 MALT1 -0.41 -6.88 -0.35 3.08e-11 Liver enzyme levels (alkaline phosphatase); CRC trans rs6129564 0.731 rs6029074 chr20:38999927 C/G cg12409982 chr3:137489312 NA -0.5 -6.04 -0.32 4.09e-9 Cranial base width; CRC cis rs13108904 0.901 rs1680073 chr4:1280337 G/A cg23123621 chr4:1343375 KIAA1530 -0.37 -6.9 -0.36 2.68e-11 Obesity-related traits; CRC cis rs713477 0.967 rs10150617 chr14:55916225 A/C cg13175173 chr14:55914753 NA 0.48 9.06 0.45 1.19e-17 Pediatric bone mineral content (femoral neck); CRC cis rs10504229 0.775 rs17804840 chr8:58157045 C/T cg21724239 chr8:58056113 NA 0.64 8.48 0.42 8e-16 Developmental language disorder (linguistic errors); CRC cis rs11971779 0.588 rs6972408 chr7:139071474 T/G cg07862535 chr7:139043722 LUC7L2 0.57 7.35 0.38 1.61e-12 Diisocyanate-induced asthma; CRC cis rs6502050 0.835 rs7502548 chr17:80087569 T/C cg09264619 chr17:80180166 NA 0.37 6.13 0.32 2.51e-9 Life satisfaction; CRC cis rs9733 0.628 rs72700895 chr1:150626029 C/T cg17724175 chr1:150552817 MCL1 0.58 9.4 0.46 9.25e-19 Tonsillectomy; CRC cis rs9487051 0.714 rs7755970 chr6:109602359 A/G cg01475377 chr6:109611718 NA -0.39 -6.75 -0.35 6.61e-11 Reticulocyte fraction of red cells; CRC cis rs2032447 0.832 rs6922788 chr6:26052291 C/T cg03264133 chr6:25882463 NA -0.46 -6.4 -0.33 5.32e-10 Intelligence (multi-trait analysis); CRC cis rs3768617 0.727 rs12066735 chr1:183101451 T/G ch.1.3577855R chr1:183094577 LAMC1 0.64 9.71 0.47 8.96e-20 Fuchs's corneal dystrophy; CRC cis rs919433 0.963 rs12617117 chr2:198155170 T/A cg10820045 chr2:198174542 NA -0.56 -9.43 -0.46 7.69e-19 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC cis rs7208859 0.623 rs1061342 chr17:29114463 G/A cg01831904 chr17:28903510 LRRC37B2 -0.63 -6.49 -0.34 3.2e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs11931598 0.783 rs28661210 chr4:7050956 C/A cg19539972 chr4:7069911 GRPEL1 0.44 6.0 0.31 5.3300000000000004e-09 Sum basophil neutrophil counts;Sum neutrophil eosinophil counts;Granulocyte count;Neutrophil count;Myeloid white cell count; CRC cis rs4803468 1.000 rs11880539 chr19:41918949 A/C cg09537434 chr19:41945824 ATP5SL 0.88 16.18 0.67 1.01e-43 Height; CRC cis rs7772486 0.790 rs2254257 chr6:146203724 C/T cg13319975 chr6:146136371 FBXO30 -0.41 -6.27 -0.33 1.14e-9 Lobe attachment (rater-scored or self-reported); CRC trans rs7267979 1.000 rs6050565 chr20:25347563 A/C cg17903999 chr18:56338584 MALT1 0.41 7.06 0.36 9.88e-12 Liver enzyme levels (alkaline phosphatase); CRC cis rs60871478 0.636 rs4276575 chr7:900035 C/T cg13844804 chr7:814759 HEATR2 -0.57 -6.43 -0.33 4.62e-10 Cerebrospinal P-tau181p levels; CRC cis rs8063761 0.689 rs4785763 chr16:90066936 G/T cg05185784 chr16:90016020 DEF8 -0.54 -7.82 -0.4 7.31e-14 Squamous cell carcinoma; CRC cis rs2243480 1.000 rs7804223 chr7:65664559 T/G cg12463550 chr7:65579703 CRCP -0.69 -6.08 -0.32 3.29e-9 Diabetic kidney disease; CRC cis rs2797685 0.617 rs172933 chr1:7844680 T/C cg06712362 chr1:7811235 CAMTA1 -0.44 -5.8 -0.3 1.53e-8 Crohn's disease; CRC cis rs561341 0.609 rs7214626 chr17:30190989 G/A cg12193833 chr17:30244370 NA 0.45 6.01 0.31 4.79e-9 Hip circumference adjusted for BMI; CRC cis rs10887265 1 rs10887265 chr10:86015573 G/C cg02698580 chr10:86016643 RGR 0.45 6.91 0.36 2.59e-11 Myopia; CRC cis rs60871478 1.000 rs35488064 chr7:812722 G/C cg13844804 chr7:814759 HEATR2 0.65 8.47 0.42 8.46e-16 Cerebrospinal P-tau181p levels; CRC cis rs11758351 0.866 rs55815656 chr6:26207303 G/A cg01420254 chr6:26195488 NA 0.77 8.9 0.44 3.75e-17 Gout;Renal underexcretion gout; CRC cis rs9325144 0.647 rs12424190 chr12:39111206 A/T cg26384229 chr12:38710491 ALG10B -0.5 -7.12 -0.37 6.99e-12 Morning vs. evening chronotype; CRC trans rs1005277 0.505 rs1208689 chr10:38097775 C/G cg23533926 chr12:111358616 MYL2 -0.45 -6.65 -0.34 1.23e-10 Extrinsic epigenetic age acceleration; CRC cis rs17376456 0.569 rs7713956 chr5:93133185 T/C cg25358565 chr5:93447407 FAM172A -0.63 -7.72 -0.39 1.41e-13 Diabetic retinopathy; CRC cis rs12681287 0.547 rs71502658 chr8:87478785 T/A cg27223183 chr8:87520930 FAM82B -0.53 -7.42 -0.38 1.01e-12 Caudate activity during reward; CRC cis rs1552244 1.000 rs7651058 chr3:10066964 C/T cg00166722 chr3:10149974 C3orf24 0.65 8.81 0.44 7.45e-17 Alzheimer's disease; CRC cis rs13161895 1.000 rs17079968 chr5:179443423 C/T cg02702477 chr5:179499311 RNF130 0.54 6.35 0.33 7.35e-10 LDL cholesterol; CRC cis rs1215050 0.740 rs2555390 chr4:98999112 A/G cg05340658 chr4:99064831 C4orf37 -0.48 -7.34 -0.38 1.65e-12 Waist-to-hip ratio adjusted for body mass index; CRC cis rs7945705 0.747 rs1123936 chr11:9003306 A/G cg00186954 chr11:8933980 ST5;C11orf17 -0.45 -7.49 -0.38 6.4e-13 Hemoglobin concentration; CRC cis rs7727544 0.735 rs2569266 chr5:131706791 T/C cg12564285 chr5:131593104 PDLIM4 -0.32 -5.82 -0.31 1.38e-8 Blood metabolite levels; CRC cis rs4629180 0.959 rs11896771 chr2:102098328 T/C cg04415270 chr2:102091202 RFX8 -0.54 -7.98 -0.4 2.45e-14 Chronic rhinosinusitis with nasal polyps; CRC cis rs1552244 0.572 rs3774208 chr3:10164722 T/G cg10729496 chr3:10149963 C3orf24 0.48 5.61 0.3 4.19e-8 Alzheimer's disease; CRC cis rs4727027 0.866 rs7778766 chr7:148806729 A/G cg23583168 chr7:148888333 NA -0.85 -13.67 -0.6 5.3e-34 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC cis rs2857891 0.909 rs56372435 chr11:6938658 T/C cg04053776 chr11:6947353 ZNF215 0.51 6.84 0.35 3.86e-11 Response to cytadine analogues (cytosine arabinoside); CRC cis rs2073300 0.609 rs2277765 chr20:23425163 C/T cg12062639 chr20:23401060 NAPB 0.81 7.38 0.38 1.27e-12 Peripheral arterial disease (traffic-related air pollution interaction); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg25942691 chr19:36705733 ZNF565;ZNF146 0.44 6.49 0.34 3.17e-10 Intelligence (multi-trait analysis); CRC cis rs832540 0.603 rs6870175 chr5:56093371 A/G cg24531977 chr5:56204891 C5orf35 -0.53 -8.0 -0.4 2.18e-14 Coronary artery disease; CRC cis rs3785574 0.962 rs9944483 chr17:61783553 G/T cg06873352 chr17:61820015 STRADA -0.51 -8.3 -0.42 2.77e-15 Height; CRC cis rs2952156 0.920 rs903502 chr17:37829604 C/T cg07936489 chr17:37558343 FBXL20 -0.42 -5.97 -0.31 6.2e-9 Asthma; CRC cis rs2153535 0.580 rs1932279 chr6:8473653 T/C cg07606381 chr6:8435919 SLC35B3 0.67 10.7 0.51 4.01e-23 Motion sickness; CRC cis rs7408868 1.000 rs8107180 chr19:15275430 T/C cg14696996 chr19:15285081 NOTCH3 0.97 8.99 0.44 1.99e-17 Pulse pressure; CRC trans rs7824557 0.564 rs2736290 chr8:11234298 C/T cg06636001 chr8:8085503 FLJ10661 -0.48 -7.2 -0.37 4.21e-12 Retinal vascular caliber; CRC cis rs28374715 0.578 rs13313520 chr15:41629127 T/G cg18705301 chr15:41695430 NDUFAF1 -1.1 -18.87 -0.72 2.42e-54 Ulcerative colitis; CRC cis rs4713118 0.513 rs200971 chr6:27858904 C/T cg12172441 chr6:28176163 NA 0.5 6.65 0.34 1.22e-10 Parkinson's disease; CRC cis rs2764208 0.860 rs205286 chr6:34551334 A/C cg07306190 chr6:34760872 UHRF1BP1 -0.34 -5.89 -0.31 9.39e-9 Systemic lupus erythematosus; CRC cis rs514406 0.505 rs431459 chr1:53183230 T/G cg08859206 chr1:53392774 SCP2 -0.4 -6.03 -0.32 4.29e-9 Monocyte count; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg11865413 chr10:72969054 NA 0.5 7.37 0.38 1.38e-12 Response to antipsychotic treatment; CRC cis rs4713118 0.869 rs9348775 chr6:27695329 C/T cg15845792 chr6:28175446 NA 0.61 8.31 0.42 2.61e-15 Parkinson's disease; CRC cis rs6973256 0.828 rs2041996 chr7:133390510 G/A cg10665199 chr7:133106180 EXOC4 -0.38 -5.64 -0.3 3.72e-8 Intelligence (multi-trait analysis); CRC cis rs11098499 0.863 rs2306457 chr4:120472839 T/A cg24375607 chr4:120327624 NA 0.48 7.29 0.37 2.35e-12 Corneal astigmatism; CRC trans rs208520 0.690 rs12204512 chr6:66710486 C/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 1.04 14.72 0.63 4.93e-38 Exhaled nitric oxide output; CRC cis rs4478858 0.746 rs10798832 chr1:31688630 C/G cg00250761 chr1:31883323 NA 0.31 5.82 0.31 1.4e-8 Alcohol dependence; CRC cis rs7072216 0.763 rs12763326 chr10:100167396 A/G cg26618903 chr10:100175079 PYROXD2 0.53 8.96 0.44 2.44e-17 Metabolite levels; CRC cis rs1552244 0.872 rs7646073 chr3:10097405 G/A cg02579736 chr3:10068473 FANCD2;CIDECP 0.97 13.13 0.59 6.13e-32 Alzheimer's disease; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg20563921 chr11:62420975 INTS5 0.42 6.09 0.32 3.21e-9 Intelligence (multi-trait analysis); CRC cis rs9462846 1.000 rs56158882 chr6:42860740 T/G cg10862848 chr6:42927986 GNMT -0.3 -5.64 -0.3 3.75e-8 Blood protein levels; CRC cis rs4481887 0.927 rs12039929 chr1:248482018 G/A cg13385794 chr1:248469461 NA 0.38 6.68 0.35 1.01e-10 Common traits (Other); CRC cis rs2120019 1.000 rs7167285 chr15:75368769 A/G cg11632617 chr15:75315747 PPCDC -0.56 -8.05 -0.41 1.52e-14 Blood trace element (Zn levels); CRC cis rs67311347 1.000 rs1466236 chr3:40462162 C/T cg24209194 chr3:40518798 ZNF619 0.45 6.89 0.36 2.81e-11 Renal cell carcinoma; CRC cis rs12188164 0.515 rs2672744 chr5:411047 A/G cg21972741 chr5:435613 AHRR -0.39 -5.65 -0.3 3.41e-8 Cystic fibrosis severity; CRC cis rs875971 0.545 rs316324 chr7:65610614 A/G cg02869306 chr7:64672164 INTS4L1 0.43 6.28 0.33 1.07e-9 Aortic root size; CRC trans rs1728785 1.000 rs1749793 chr16:68569312 C/T cg04657470 chr2:198365150 HSPE1;HSPD1 0.76 8.91 0.44 3.53e-17 Ulcerative colitis; CRC cis rs10504229 1.000 rs77823122 chr8:58170161 A/G cg02725872 chr8:58115012 NA -0.38 -6.43 -0.33 4.44e-10 Developmental language disorder (linguistic errors); CRC cis rs1008375 0.966 rs4698638 chr4:17632988 G/C cg02297831 chr4:17616191 MED28 0.43 5.76 0.3 1.98e-8 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs6088590 1.000 rs6119516 chr20:33328024 C/T cg08999081 chr20:33150536 PIGU 0.49 8.38 0.42 1.59e-15 Coronary artery disease; CRC cis rs4700695 0.841 rs448454 chr5:65293462 G/A cg21114390 chr5:65439923 SFRS12 0.5 6.3 0.33 9.48e-10 Facial morphology (factor 19); CRC cis rs62432291 0.681 rs439126 chr6:159656632 T/C cg14500486 chr6:159655392 FNDC1 -0.76 -10.39 -0.5 4.8e-22 Joint mobility (Beighton score); CRC cis rs7412746 0.611 rs111905669 chr1:150777565 T/C cg18016565 chr1:150552671 MCL1 0.43 5.91 0.31 8.57e-9 Melanoma; CRC cis rs77633900 0.772 rs284903 chr15:76744813 G/A cg21673338 chr15:77095150 SCAPER -0.69 -6.18 -0.32 1.89e-9 Non-glioblastoma glioma;Glioma; CRC cis rs2032447 0.610 rs189911 chr6:25965942 A/G cg12588279 chr6:26043732 HIST1H2BB 0.42 6.06 0.32 3.77e-9 Intelligence (multi-trait analysis); CRC cis rs231513 0.954 rs231504 chr17:41970906 C/G cg26893861 chr17:41843967 DUSP3 -0.63 -6.41 -0.33 4.92e-10 Cognitive function; CRC cis rs9311474 0.508 rs7652191 chr3:52610415 T/C cg18099408 chr3:52552593 STAB1 -0.46 -7.97 -0.4 2.56e-14 Electroencephalogram traits; CRC cis rs941873 0.868 rs7898 chr10:81114959 C/T cg09469691 chr10:81107165 PPIF 0.49 7.77 0.39 1.01e-13 Height; CRC cis rs7632954 1.000 rs9863622 chr3:8524604 C/T cg03495237 chr3:8533978 NA 0.33 5.88 0.31 9.99e-9 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC trans rs916888 0.773 rs199447 chr17:44812188 C/T cg07870213 chr5:140052090 DND1 1.01 11.6 0.54 2.65e-26 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs11190604 1.000 rs12219789 chr10:102213778 A/G cg16342193 chr10:102329863 NA -0.37 -6.1 -0.32 2.96e-9 Palmitoleic acid (16:1n-7) levels; CRC cis rs7773004 0.905 rs6932727 chr6:26327087 C/A cg00631329 chr6:26305371 NA -0.4 -6.89 -0.36 2.86e-11 Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for body mass index;Waist circumference adjusted for BMI in non-smokers;Waist circumference adjusted for BMI (adjusted for smoking behaviour); CRC cis rs7412746 0.611 rs66847267 chr1:150875173 C/A cg17724175 chr1:150552817 MCL1 0.39 6.0 0.31 5.11e-9 Melanoma; CRC cis rs4658101 0.700 rs10874796 chr1:92050825 T/C cg24006770 chr1:92056542 NA 0.46 6.84 0.35 3.97e-11 Optic disc area;Vertical cup-disc ratio; CRC cis rs1814175 0.529 rs1988417 chr11:49932430 A/G cg02254774 chr11:50257496 LOC441601 -0.47 -6.62 -0.34 1.47e-10 Height; CRC cis rs35110281 0.748 rs2838322 chr21:44998615 G/C cg01579765 chr21:45077557 HSF2BP -0.37 -7.1 -0.36 7.67e-12 Mean corpuscular volume; CRC cis rs1971762 0.527 rs2365343 chr12:54038149 C/T cg06632207 chr12:54070931 ATP5G2 -0.48 -8.72 -0.43 1.41e-16 Height; CRC cis rs1451375 0.669 rs4512339 chr7:50646977 C/T cg14593290 chr7:50529359 DDC -0.53 -7.32 -0.37 1.9e-12 Malaria; CRC cis rs7618501 0.574 rs6765484 chr3:50041313 C/T cg05623727 chr3:50126028 RBM5 -0.43 -7.24 -0.37 3.18e-12 Intelligence (multi-trait analysis); CRC cis rs6961069 0.935 rs819437 chr7:80223996 C/T cg04458919 chr7:80252533 CD36 -0.33 -5.79 -0.3 1.65e-8 Platelet count; CRC cis rs2228479 0.702 rs11649501 chr16:89850957 A/T cg06656553 chr16:89960601 TCF25 -0.7 -5.81 -0.3 1.51e-8 Skin colour saturation; CRC cis rs1691799 0.867 rs2172881 chr12:66766039 C/G cg16791601 chr12:66731901 HELB -0.65 -11.09 -0.52 1.72e-24 White blood cell count (basophil); CRC trans rs7615952 0.512 rs2979351 chr3:125363599 C/T cg02560186 chr11:3602584 NA -0.63 -9.51 -0.46 4.23e-19 Blood pressure (smoking interaction); CRC cis rs7617773 0.780 rs11706277 chr3:48360433 A/G cg11946769 chr3:48343235 NME6 0.74 9.89 0.48 2.29e-20 Coronary artery disease; CRC cis rs9660992 0.686 rs1668870 chr1:205239031 C/G cg21643547 chr1:205240462 TMCC2 -0.45 -7.26 -0.37 2.84e-12 Mean corpuscular volume;Mean platelet volume; CRC cis rs11123170 0.542 rs28522253 chr2:113967387 G/A cg21550016 chr2:113992930 PAX8;LOC440839;LOC654433 0.52 6.17 0.32 2.05e-9 Renal function-related traits (BUN); CRC cis rs1843834 0.539 rs6739735 chr2:225405253 A/G cg22455342 chr2:225449267 CUL3 -0.68 -9.28 -0.46 2.26e-18 IgE levels in asthmatics (D.p. specific); CRC cis rs12541335 0.639 rs6993855 chr8:22163797 A/G cg02463440 chr8:22132932 PIWIL2 0.54 9.59 0.47 2.29e-19 Hypertriglyceridemia; CRC cis rs853679 0.517 rs9380062 chr6:28137569 G/A cg12273811 chr6:28175739 NA 0.73 9.16 0.45 5.8e-18 Depression; CRC trans rs1997103 0.871 rs6956733 chr7:55393032 A/C cg20935933 chr6:143382018 AIG1 0.53 6.11 0.32 2.85e-9 QRS interval (sulfonylurea treatment interaction); CRC cis rs7215564 0.908 rs34333328 chr17:78683420 G/A cg09596252 chr17:78655493 RPTOR 0.56 6.15 0.32 2.26e-9 Myopia (pathological); CRC cis rs7224737 0.750 rs12325861 chr17:40289412 T/C cg20291162 chr17:40259547 DHX58 -0.45 -5.82 -0.31 1.39e-8 Fibrinogen levels; CRC cis rs720844 0.684 rs930652 chr2:149317494 C/T cg09247360 chr2:149335327 NA -0.56 -6.03 -0.32 4.49e-9 Peripheral arterial disease (traffic-related air pollution interaction); CRC trans rs12699921 0.572 rs2030725 chr7:17868331 T/C cg02066331 chr6:17282778 RBM24 -0.35 -6.02 -0.31 4.63e-9 Fibrinogen levels; CRC cis rs9611565 0.512 rs139573 chr22:42214785 G/A cg06634786 chr22:41940651 POLR3H -0.71 -7.86 -0.4 5.55e-14 Vitiligo; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg03108330 chr19:2900762 ZNF57 0.34 6.0 0.31 5.09e-9 Liver disease severity in Alagille syndrome; CRC cis rs1005277 0.522 rs289648 chr10:37971837 T/C cg25427524 chr10:38739819 LOC399744 -0.72 -12.19 -0.56 1.9e-28 Extrinsic epigenetic age acceleration; CRC cis rs1129187 0.967 rs3805952 chr6:42937126 C/T cg03790207 chr6:42947109 PEX6 -0.44 -6.18 -0.32 1.92e-9 Alzheimer's disease in APOE e4+ carriers; CRC cis rs916888 0.773 rs169201 chr17:44790203 A/G cg01570182 chr17:44337453 NA 1.26 14.07 0.61 1.59e-35 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs9292777 0.720 rs4957130 chr5:40399541 C/A cg09067459 chr5:40385259 NA -0.55 -8.97 -0.44 2.31e-17 Crohn's disease;Multiple sclerosis; CRC cis rs6860806 0.507 rs273912 chr5:131661349 A/C cg24060327 chr5:131705240 SLC22A5 0.51 7.56 0.38 4.17e-13 Breast cancer; CRC cis rs2223471 0.870 rs2744494 chr6:50757690 G/A cg03432817 chr6:50765336 NA 0.38 6.02 0.32 4.54e-9 Subcutaneous adipose tissue; CRC cis rs7762018 1.000 rs6942332 chr6:170131934 A/G cg17545662 chr6:170176663 C6orf70 0.57 6.54 0.34 2.31e-10 Thiazide-induced adverse metabolic effects in hypertensive patients; CRC cis rs2836974 0.897 rs2836928 chr21:40543320 C/T cg11890956 chr21:40555474 PSMG1 1.01 16.04 0.66 3.52e-43 Cognitive function; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg01110552 chr10:103578627 MGEA5 0.47 6.75 0.35 6.7e-11 Response to antipsychotic treatment; CRC cis rs4716602 0.609 rs12386633 chr7:156158232 G/C cg16983916 chr7:156159713 NA -0.39 -6.92 -0.36 2.42e-11 Anti-saccade response; CRC cis rs1348850 0.526 rs1345138 chr2:178387100 A/T cg27490568 chr2:178487706 NA 0.62 7.51 0.38 5.45e-13 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs10484885 0.553 rs6901718 chr6:90243843 G/A cg13799429 chr6:90582589 CASP8AP2 -0.55 -6.14 -0.32 2.37e-9 QRS interval (sulfonylurea treatment interaction); CRC cis rs7617773 0.743 rs13071960 chr3:48367537 A/G cg11946769 chr3:48343235 NME6 0.72 9.58 0.47 2.48e-19 Coronary artery disease; CRC cis rs7197653 0.748 rs61460037 chr16:68336125 A/C cg09835421 chr16:68378352 PRMT7 -0.8 -8.16 -0.41 7.05e-15 Magnesium levels; CRC cis rs2153535 0.580 rs9392223 chr6:8468650 G/A cg07606381 chr6:8435919 SLC35B3 0.68 10.93 0.52 6.5e-24 Motion sickness; CRC cis rs34172651 0.517 rs2287783 chr16:24831727 C/T cg06028605 chr16:24865363 SLC5A11 0.58 9.64 0.47 1.6e-19 Intelligence (multi-trait analysis); CRC trans rs61931739 0.500 rs10844845 chr12:34381117 C/T cg26384229 chr12:38710491 ALG10B 0.62 9.04 0.45 1.43e-17 Morning vs. evening chronotype; CRC cis rs7666738 0.612 rs6830172 chr4:99093947 G/A cg17366294 chr4:99064904 C4orf37 0.35 5.67 0.3 3.18e-8 Colonoscopy-negative controls vs population controls; CRC cis rs6681460 1.000 rs1325263 chr1:67129791 C/A cg02459107 chr1:67143332 SGIP1 0.46 7.95 0.4 3.03e-14 Presence of antiphospholipid antibodies; CRC trans rs10028773 0.515 rs9994488 chr4:120587781 C/T cg25214090 chr10:38739885 LOC399744 0.49 7.64 0.39 2.47e-13 Educational attainment; CRC cis rs2228479 0.717 rs1061647 chr16:89806063 G/C cg06656553 chr16:89960601 TCF25 -0.68 -5.67 -0.3 3.16e-8 Skin colour saturation; CRC cis rs4838594 0.563 rs4838598 chr10:49679413 A/G cg17291251 chr10:49678358 ARHGAP22 0.44 7.01 0.36 1.33e-11 Daytime sleep phenotypes; CRC cis rs12760731 0.920 rs16852934 chr1:178479290 C/T cg00404053 chr1:178313656 RASAL2 0.61 7.17 0.37 5.02e-12 Obesity-related traits; CRC cis rs6662572 0.703 rs55641506 chr1:46580708 G/A cg08644498 chr1:46502608 NA 0.43 7.01 0.36 1.32e-11 Blood protein levels; CRC trans rs66759488 0.739 rs10851451 chr15:47608991 A/G cg00329300 chr1:161008462 TSTD1 -0.47 -7.11 -0.36 7.05e-12 Lung cancer; CRC cis rs926938 0.618 rs516985 chr1:115495011 G/A cg12756093 chr1:115239321 AMPD1 0.58 8.98 0.44 2.17e-17 Autism; CRC cis rs7953508 0.506 rs768775 chr12:93968197 T/C cg18151635 chr12:93972918 NA -0.8 -11.58 -0.54 2.97e-26 Pubertal anthropometrics; CRC cis rs8180040 1.000 rs11130127 chr3:47398793 C/G cg10298567 chr3:47292165 KIF9 0.43 7.06 0.36 1.02e-11 Colorectal cancer; CRC cis rs1451375 0.959 rs17133878 chr7:50620927 T/C cg14593290 chr7:50529359 DDC 0.5 7.17 0.37 5.13e-12 Malaria; CRC cis rs9467711 0.606 rs34622023 chr6:26362119 A/T cg14345882 chr6:26364793 BTN3A2 0.64 5.63 0.3 3.85e-8 Autism spectrum disorder or schizophrenia; CRC cis rs9486719 1.000 rs2472882 chr6:96863474 C/T cg06623918 chr6:96969491 KIAA0776 0.81 9.48 0.46 5.18e-19 Migraine;Coronary artery disease; CRC cis rs4972806 0.739 rs10834 chr2:177042087 A/G cg10305451 chr2:177043427 NA 0.62 8.88 0.44 4.28e-17 IgG glycosylation; CRC cis rs7208859 0.623 rs73269974 chr17:29112384 C/T cg01831904 chr17:28903510 LRRC37B2 -0.63 -6.45 -0.33 4.07e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg16402443 chr7:2598526 IQCE 0.43 6.82 0.35 4.34e-11 Liver disease severity in Alagille syndrome; CRC cis rs13118159 0.836 rs12647145 chr4:1338618 C/A cg20092199 chr4:1342459 KIAA1530 0.33 5.77 0.3 1.87e-8 Longevity; CRC cis rs3087591 1.000 rs2905877 chr17:29543269 A/C cg24425628 chr17:29625626 OMG;NF1 -0.77 -13.97 -0.61 3.77e-35 Hip circumference; CRC cis rs1707322 0.963 rs10890373 chr1:46393755 A/C cg06784218 chr1:46089804 CCDC17 0.58 10.23 0.49 1.63e-21 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs7849270 1.000 rs10760589 chr9:131906293 T/C cg13538475 chr9:131942899 NA -0.29 -5.74 -0.3 2.11e-8 Blood metabolite ratios; CRC trans rs1814175 0.630 rs1722019 chr11:49904102 G/A cg21153622 chr11:89784906 NA -0.42 -6.96 -0.36 1.85e-11 Height; CRC cis rs7312933 0.934 rs11181289 chr12:42402342 C/T cg17420585 chr12:42539391 GXYLT1 -0.43 -6.15 -0.32 2.2e-9 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CRC cis rs4973397 0.765 rs13030174 chr2:232271284 A/C cg13347044 chr2:232276743 NA 0.47 6.74 0.35 7.12e-11 Anti-saccade response; CRC cis rs2032447 0.966 rs7756117 chr6:26046565 A/G cg03517284 chr6:25882590 NA 0.43 6.0 0.31 5.07e-9 Intelligence (multi-trait analysis); CRC cis rs736408 0.527 rs2336147 chr3:52626443 T/C cg08222913 chr3:52553049 STAB1 -0.38 -7.52 -0.38 5.33e-13 Bipolar disorder; CRC cis rs8180040 0.967 rs807935 chr3:47321669 A/G cg10298567 chr3:47292165 KIF9 -0.4 -6.72 -0.35 7.9e-11 Colorectal cancer; CRC cis rs11123170 0.640 rs931472 chr2:113969948 C/T cg11763394 chr2:113992921 PAX8;LOC440839;LOC654433 -0.55 -7.38 -0.38 1.31e-12 Renal function-related traits (BUN); CRC cis rs10504229 0.683 rs16921829 chr8:58110950 A/G cg04204079 chr8:58130323 NA -0.47 -5.94 -0.31 7.15e-9 Developmental language disorder (linguistic errors); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg26839812 chr6:16129282 MYLIP 0.43 6.03 0.32 4.45e-9 Response to antipsychotic treatment; CRC cis rs8077889 0.917 rs72836545 chr17:41892602 A/G cg26893861 chr17:41843967 DUSP3 0.95 12.4 0.56 3.19e-29 Triglycerides; CRC cis rs62103177 0.759 rs7227794 chr18:77610925 C/T cg12964065 chr18:77638022 KCNG2 0.57 6.04 0.32 4.19e-9 Opioid sensitivity; CRC cis rs6502050 0.835 rs7502676 chr17:80093433 C/G cg11859384 chr17:80120422 CCDC57 -0.35 -5.6 -0.3 4.44e-8 Life satisfaction; CRC cis rs853679 0.517 rs3823180 chr6:28061744 G/A cg15786705 chr6:28176104 NA 0.76 9.63 0.47 1.68e-19 Depression; CRC trans rs7615952 0.800 rs13086460 chr3:125646417 C/T cg07211511 chr3:129823064 LOC729375 -1.07 -17.81 -0.7 3.74e-50 Blood pressure (smoking interaction); CRC trans rs6129564 0.731 rs1969696 chr20:38989872 T/C cg12409982 chr3:137489312 NA -0.44 -5.97 -0.31 6e-9 Cranial base width; CRC cis rs17253792 0.822 rs74051609 chr14:56171132 G/A cg01858014 chr14:56050164 KTN1 -0.72 -6.94 -0.36 2.05e-11 Putamen volume; CRC cis rs67311347 1.000 rs9827461 chr3:40489351 T/A cg09455208 chr3:40491958 NA 0.49 9.65 0.47 1.48e-19 Renal cell carcinoma; CRC cis rs35110281 0.774 rs2838323 chr21:44999086 G/A cg04455712 chr21:45112962 RRP1B 0.4 7.84 0.4 6.44e-14 Mean corpuscular volume; CRC cis rs6426558 0.621 rs7521639 chr1:227223736 T/C cg10327440 chr1:227177885 CDC42BPA 0.65 10.95 0.52 5.25e-24 Neutrophil percentage of white cells; CRC cis rs1153858 0.621 rs2413769 chr15:45561868 A/C cg21132104 chr15:45694354 SPATA5L1 0.56 7.42 0.38 1.01e-12 Homoarginine levels; CRC trans rs6951245 0.935 rs79143504 chr7:1110212 A/G cg13565492 chr6:43139072 SRF -0.72 -7.27 -0.37 2.59e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs4790333 0.537 rs2447106 chr17:2257819 A/T cg02569219 chr17:2266849 SGSM2 -0.38 -6.32 -0.33 8.55e-10 Proinsulin levels; CRC cis rs514406 0.825 rs1242328 chr1:53396869 A/G cg08859206 chr1:53392774 SCP2 -0.48 -7.53 -0.38 4.8e-13 Monocyte count; CRC cis rs4713118 0.621 rs4713133 chr6:28034041 T/C cg02683197 chr6:28174875 NA 0.72 8.85 0.44 5.44e-17 Parkinson's disease; CRC cis rs231513 0.954 rs231494 chr17:41976928 G/C cg26893861 chr17:41843967 DUSP3 -0.62 -6.27 -0.33 1.11e-9 Cognitive function; CRC cis rs3785574 0.962 rs2727324 chr17:61922102 G/C cg22520471 chr17:61851767 DDX42;CCDC47 0.43 5.95 0.31 6.71e-9 Height; CRC cis rs7659604 0.967 rs10008348 chr4:122666987 A/C cg06713675 chr4:122721982 EXOSC9 -0.39 -6.34 -0.33 7.65e-10 Type 2 diabetes; CRC cis rs875971 0.522 rs34973832 chr7:65396204 A/G cg02869306 chr7:64672164 INTS4L1 -0.35 -5.89 -0.31 9.64e-9 Aortic root size; CRC cis rs2279817 0.863 rs12757678 chr1:17983680 G/C cg21791023 chr1:18019539 ARHGEF10L -0.51 -5.67 -0.3 3.19e-8 Neuroticism; CRC cis rs7618501 0.669 rs7634084 chr3:49949834 A/T cg24308560 chr3:49941425 MST1R -0.55 -9.14 -0.45 6.65e-18 Intelligence (multi-trait analysis); CRC cis rs7589728 0.925 rs80065975 chr2:88502758 G/A cg24977027 chr2:88469347 THNSL2 0.52 5.94 0.31 7.21e-9 Plasma clusterin levels; CRC cis rs853679 0.760 rs11962305 chr6:28199937 G/C cg12172441 chr6:28176163 NA 0.56 5.8 0.3 1.54e-8 Depression; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg22297305 chr22:18923471 PRODH 0.39 6.16 0.32 2.11e-9 Intelligence (multi-trait analysis); CRC cis rs10413329 0.810 rs10401950 chr19:13101197 C/G cg13338734 chr19:13113668 NFIX 0.33 5.66 0.3 3.23e-8 Intelligence (multi-trait analysis); CRC trans rs1814175 0.669 rs12416837 chr11:49669761 G/T cg11707556 chr5:10655725 ANKRD33B -0.35 -6.59 -0.34 1.73e-10 Height; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg26027482 chr12:1100598 ERC1 0.45 6.37 0.33 6.33e-10 Response to antipsychotic treatment; CRC cis rs801193 0.660 rs1962050 chr7:66240008 C/T cg12463550 chr7:65579703 CRCP -0.45 -6.27 -0.33 1.13e-9 Aortic root size; CRC cis rs9858542 0.953 rs11706370 chr3:49441091 G/A cg07274523 chr3:49395745 GPX1 0.46 6.23 0.32 1.46e-9 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs524281 0.861 rs535395 chr11:65906534 A/G cg16950941 chr11:66035639 RAB1B 0.57 7.25 0.37 2.94e-12 Electroencephalogram traits; CRC trans rs2797160 0.967 rs1578793 chr6:126015057 A/G cg05039488 chr6:79577232 IRAK1BP1 0.51 7.59 0.39 3.37e-13 Endometrial cancer; CRC cis rs2404602 0.622 rs11632670 chr15:76974055 A/G cg23625390 chr15:77176239 SCAPER -0.83 -13.88 -0.61 8.38e-35 Blood metabolite levels; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg06102153 chr16:4674926 MGRN1 0.42 6.89 0.36 2.78e-11 Liver disease severity in Alagille syndrome; CRC cis rs720844 1.000 rs1020468 chr2:149334413 A/G cg09247360 chr2:149335327 NA -0.61 -7.68 -0.39 1.87e-13 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs10911232 0.507 rs28477876 chr1:183019882 T/C ch.1.3577855R chr1:183094577 LAMC1 0.83 14.62 0.63 1.23e-37 Hypertriglyceridemia; CRC trans rs9393777 0.920 rs34150729 chr6:27388754 T/C cg06606381 chr12:133084897 FBRSL1 -1.12 -7.45 -0.38 8.43e-13 Intelligence (multi-trait analysis); CRC cis rs875971 1.000 rs778726 chr7:65828731 C/T cg18912574 chr7:65842487 NCRNA00174 0.36 6.18 0.32 1.92e-9 Aortic root size; CRC cis rs9467773 0.595 rs12525810 chr6:26623511 T/A cg09904177 chr6:26538194 HMGN4 0.64 9.29 0.46 2.2e-18 Intelligence (multi-trait analysis); CRC cis rs12906542 0.507 rs4395040 chr15:78282533 G/A cg01794103 chr15:78342494 TBC1D2B 0.43 5.9 0.31 9.1e-9 Breast cancer; CRC cis rs6963495 0.818 rs73190149 chr7:105152793 C/T cg13798780 chr7:105162888 PUS7 0.67 7.93 0.4 3.42e-14 Bipolar disorder (body mass index interaction); CRC cis rs644799 1.000 rs632388 chr11:95563775 A/G cg25478527 chr11:95522999 CEP57;FAM76B 0.52 7.86 0.4 5.6e-14 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs9467603 1.000 rs9467606 chr6:25809218 A/G cg16898833 chr6:26189333 HIST1H4D 0.77 6.45 0.33 4.07e-10 Intelligence (multi-trait analysis); CRC cis rs11677370 0.574 rs11686118 chr2:3854938 C/T cg17052675 chr2:3827356 NA -0.68 -11.08 -0.52 1.78e-24 Type 2 diabetes; CRC cis rs10504229 0.683 rs56208052 chr8:58130207 A/T cg05313129 chr8:58192883 C8orf71 -0.43 -6.11 -0.32 2.74e-9 Developmental language disorder (linguistic errors); CRC cis rs6964587 0.967 rs6465353 chr7:91779971 G/T cg17063962 chr7:91808500 NA -0.85 -15.69 -0.65 8.57e-42 Breast cancer; CRC cis rs910316 1.000 rs12589876 chr14:75544189 G/A cg11812906 chr14:75593930 NEK9 0.62 9.87 0.48 2.72e-20 Height; CRC cis rs8114671 0.836 rs734308 chr20:33572096 A/G cg07148914 chr20:33460835 GGT7 -0.36 -5.77 -0.3 1.86e-8 Height; CRC trans rs7726839 0.574 rs72705017 chr5:623733 G/A cg11887960 chr12:57824829 NA 0.59 6.57 0.34 2e-10 Obesity-related traits; CRC cis rs79839061 0.520 rs6842808 chr4:906903 C/T cg07828340 chr4:882639 GAK 1.1 11.18 0.52 8.1e-25 Intelligence (multi-trait analysis); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg23739036 chr1:2343736 PEX10 0.44 6.23 0.32 1.43e-9 Response to antipsychotic treatment; CRC cis rs8177253 1.000 rs8177272 chr3:133482870 C/T cg01448562 chr3:133502909 NA -0.53 -9.02 -0.45 1.65e-17 Iron status biomarkers; CRC cis rs4964805 0.559 rs1469999 chr12:104208111 A/G cg02344784 chr12:104178138 NT5DC3 -0.48 -6.66 -0.34 1.12e-10 Attention deficit hyperactivity disorder; CRC trans rs4332037 0.539 rs1533827 chr7:2074290 A/G cg11693508 chr17:37793320 STARD3 -0.63 -7.62 -0.39 2.69e-13 Bipolar disorder; CRC cis rs875971 0.660 rs12698534 chr7:65986845 C/T cg18876405 chr7:65276391 NA 0.6 10.94 0.52 5.87e-24 Aortic root size; CRC cis rs832540 0.898 rs252888 chr5:56227326 T/A cg24531977 chr5:56204891 C5orf35 -0.48 -7.36 -0.38 1.45e-12 Coronary artery disease; CRC cis rs2839186 0.771 rs2280959 chr21:47641996 C/G cg13012494 chr21:47604986 C21orf56 0.46 7.26 0.37 2.86e-12 Testicular germ cell tumor; CRC cis rs9948 0.655 rs17119564 chr2:97384728 G/A cg20312557 chr2:97357134 FER1L5 -0.61 -5.68 -0.3 2.93e-8 Erectile dysfunction and prostate cancer treatment; CRC cis rs7208859 0.673 rs11080138 chr17:29224542 A/G cg14008862 chr17:28927542 LRRC37B2 0.55 5.75 0.3 2.04e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs7552404 0.921 rs10873685 chr1:76218818 A/C cg10523679 chr1:76189770 ACADM 0.86 11.87 0.55 2.82e-27 Blood metabolite levels;Acylcarnitine levels; CRC cis rs644799 1.000 rs627568 chr11:95569253 A/C cg25478527 chr11:95522999 CEP57;FAM76B 0.52 7.67 0.39 1.98e-13 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs834811 0.602 rs7779031 chr7:135889681 A/G cg01726295 chr7:135938950 NA -0.35 -6.08 -0.32 3.24e-9 Post-traumatic stress disorder; CRC cis rs7085104 0.660 rs7902804 chr10:104585405 A/T cg08772003 chr10:104629869 AS3MT -0.38 -6.47 -0.34 3.57e-10 Immature fraction of reticulocytes;Schizophrenia; CRC cis rs28386778 0.897 rs2584615 chr17:61927774 T/C cg06601766 chr17:61851465 DDX42;CCDC47 0.42 5.77 0.3 1.86e-8 Prudent dietary pattern; CRC cis rs9747201 1.000 rs12451470 chr17:80177532 G/A cg23141183 chr17:80185318 SLC16A3 0.42 5.88 0.31 1.01e-8 Peripheral arterial disease (traffic-related air pollution interaction); CRC trans rs10863936 0.558 rs7522330 chr1:212234104 A/T cg03890664 chr19:10613492 KEAP1 -0.43 -6.0 -0.31 5.1e-9 Height; CRC trans rs10155879 0.505 rs12704265 chr7:86142678 A/G cg27383975 chr19:17356182 NR2F6 0.56 6.32 0.33 8.4e-10 Interleukin-4 levels; CRC cis rs8103278 1.000 rs1548029 chr19:46309203 A/C cg14061069 chr19:46274453 DMPK -0.54 -8.24 -0.41 4.04e-15 Coronary artery disease; CRC cis rs875971 0.929 rs778682 chr7:65837934 A/G cg12463550 chr7:65579703 CRCP 0.48 6.96 0.36 1.89e-11 Aortic root size; CRC cis rs12477438 0.765 rs6750876 chr2:99679673 C/T cg14399236 chr2:99771627 LIPT1;TSGA10 -0.6 -8.19 -0.41 6.03e-15 Chronic sinus infection; CRC cis rs4942783 0.647 rs9590972 chr13:31583488 A/G cg22761482 chr13:31579400 NA -0.33 -5.77 -0.3 1.83e-8 Subjective well-being; CRC cis rs2976388 0.590 rs7828042 chr8:143819383 A/G cg20041105 chr8:143859282 LYNX1 -0.41 -6.78 -0.35 5.61e-11 Urinary tract infection frequency; CRC cis rs13108904 0.967 rs12642396 chr4:1293055 C/A cg16405210 chr4:1374714 KIAA1530 -0.44 -5.94 -0.31 7.1e-9 Obesity-related traits; CRC cis rs77861329 0.748 rs735768 chr3:52174970 A/C cg08692210 chr3:52188851 WDR51A 0.5 5.98 0.31 5.82e-9 Macrophage inflammatory protein 1b levels; CRC cis rs12325245 0.536 rs8058781 chr16:58653838 G/A cg26666090 chr16:58549219 SETD6 0.94 6.49 0.34 3.19e-10 Schizophrenia; CRC trans rs7395662 0.889 rs1848158 chr11:48697294 C/T cg21153622 chr11:89784906 NA -0.48 -7.7 -0.39 1.59e-13 HDL cholesterol; CRC cis rs6495122 0.644 rs11630087 chr15:75261673 G/T cg21523564 chr15:75251491 NA 0.42 6.12 0.32 2.65e-9 Caffeine consumption;Diastolic blood pressure;Coffee consumption; CRC cis rs6088580 0.609 rs2378205 chr20:33110803 C/G cg08999081 chr20:33150536 PIGU 0.63 11.63 0.54 1.96e-26 Glomerular filtration rate (creatinine); CRC cis rs11122272 0.705 rs2486731 chr1:231532511 C/T cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX 0.51 7.52 0.38 5.19e-13 Hemoglobin concentration; CRC cis rs7618501 1.000 rs695238 chr3:49869158 A/C cg24308560 chr3:49941425 MST1R -0.45 -7.12 -0.37 6.61e-12 Intelligence (multi-trait analysis); CRC cis rs5769765 0.862 rs9616385 chr22:50313124 C/T cg22709217 chr22:50311962 ALG12;CRELD2 -1.12 -18.26 -0.71 6.49e-52 Schizophrenia; CRC cis rs10504229 0.906 rs113823909 chr8:58170635 A/G cg05313129 chr8:58192883 C8orf71 -0.47 -6.93 -0.36 2.23e-11 Developmental language disorder (linguistic errors); CRC cis rs997295 0.570 rs17241808 chr15:67892792 A/G cg24247231 chr15:67904302 MAP2K5 -0.33 -5.8 -0.3 1.52e-8 Motion sickness; CRC cis rs807669 0.548 rs723414 chr22:19185736 G/A cg02655711 chr22:19163373 SLC25A1 0.76 13.5 0.6 2.46e-33 Metabolite levels; CRC cis rs2652834 0.904 rs2729826 chr15:63360446 C/G cg05507819 chr15:63340323 TPM1 -0.45 -6.16 -0.32 2.09e-9 HDL cholesterol; CRC cis rs113835537 0.935 rs117480267 chr11:66398596 C/T cg22134325 chr11:66188745 NPAS4 0.37 6.28 0.33 1.1e-9 Airway imaging phenotypes; CRC cis rs713587 0.776 rs3731623 chr2:25163783 T/C cg04586622 chr2:25135609 ADCY3 -0.35 -6.04 -0.32 4.15e-9 Body mass index in non-asthmatics; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg22583711 chr7:154795321 PAXIP1;LOC202781 0.43 7.0 0.36 1.42e-11 Liver disease severity in Alagille syndrome; CRC cis rs853679 0.569 rs9348798 chr6:28143011 G/A cg02683197 chr6:28174875 NA 0.88 10.83 0.51 1.42e-23 Depression; CRC cis rs1552244 1.000 rs9881859 chr3:10072814 A/T cg10729496 chr3:10149963 C3orf24 0.5 6.6 0.34 1.61e-10 Alzheimer's disease; CRC cis rs9894429 0.621 rs7502337 chr17:79588470 T/C cg09655341 chr17:79618100 PDE6G -0.35 -5.94 -0.31 7.05e-9 Eye color traits; CRC cis rs41005 1.000 rs193929 chr2:8107620 G/T cg03155496 chr2:8117019 LOC339788 0.41 7.48 0.38 7.01e-13 Response to anti-TNF therapy in rheumatoid arthritis; CRC cis rs9649213 0.593 rs7795176 chr7:97978287 A/C cg24562669 chr7:97807699 LMTK2 0.45 7.43 0.38 9.75e-13 Prostate cancer (SNP x SNP interaction); CRC cis rs12142240 0.698 rs6703374 chr1:46862332 C/G cg00530320 chr1:46809349 NSUN4 0.59 8.07 0.41 1.35e-14 Menopause (age at onset); CRC cis rs611744 0.647 rs2848620 chr8:109249551 G/T cg21045802 chr8:109455806 TTC35 0.42 6.68 0.35 1.05e-10 Dupuytren's disease; CRC cis rs514406 0.760 rs475969 chr1:53292607 T/A cg08859206 chr1:53392774 SCP2 -0.63 -10.31 -0.49 8.81e-22 Monocyte count; CRC cis rs8072100 0.934 rs6504872 chr17:45438952 C/T cg08085267 chr17:45401833 C17orf57 -0.73 -12.76 -0.58 1.48e-30 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs11971779 0.680 rs10229249 chr7:139052510 A/T cg07862535 chr7:139043722 LUC7L2 0.57 7.35 0.38 1.61e-12 Diisocyanate-induced asthma; CRC cis rs13631 0.728 rs7466635 chr9:139980417 T/C cg11611856 chr9:139973337 UAP1L1 -0.51 -8.05 -0.41 1.53e-14 Cerebrospinal fluid biomarker levels; CRC trans rs66759488 0.739 rs10851451 chr15:47608991 A/G cg04919811 chr17:78870302 RPTOR -0.45 -6.3 -0.33 9.66e-10 Lung cancer; CRC cis rs11958404 0.932 rs72816564 chr5:157427484 T/C cg05962755 chr5:157440814 NA 1.01 12.84 0.58 7.03e-31 IgG glycosylation; CRC cis rs6500395 0.962 rs1564980 chr16:48651377 A/T cg04672837 chr16:48644449 N4BP1 0.43 6.26 0.33 1.22e-9 Response to tocilizumab in rheumatoid arthritis; CRC cis rs1790761 0.967 rs7131041 chr11:67230184 A/T cg17375396 chr11:67202808 RPS6KB2 0.33 5.78 0.3 1.78e-8 Mean corpuscular volume; CRC cis rs826838 0.616 rs7977357 chr12:38626008 C/G cg13010199 chr12:38710504 ALG10B -0.42 -6.03 -0.32 4.33e-9 Heart rate; CRC cis rs9287719 0.967 rs7563816 chr2:10763400 C/T cg00105475 chr2:10696890 NA 0.45 7.29 0.37 2.26e-12 Prostate cancer; CRC cis rs61774743 0.636 rs1892423 chr1:41849340 A/C cg08462924 chr1:41848221 NA 0.4 6.19 0.32 1.83e-9 Intelligence (multi-trait analysis); CRC cis rs4604732 0.631 rs12038880 chr1:247624603 A/G cg02104434 chr1:247694406 LOC148824;OR2C3 0.66 9.42 0.46 8.3e-19 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CRC cis rs6951245 1.000 rs11768761 chr7:1069807 A/G cg04025307 chr7:1156635 C7orf50 0.63 6.63 0.34 1.41e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs17270561 0.609 rs9358885 chr6:25758024 T/C cg17691542 chr6:26056736 HIST1H1C 0.73 9.24 0.45 3.13e-18 Iron status biomarkers; CRC cis rs9322193 0.847 rs12210605 chr6:150138403 A/G cg07701084 chr6:150067640 NUP43 0.59 8.09 0.41 1.16e-14 Lung cancer; CRC cis rs2932538 0.922 rs6681371 chr1:113101168 A/C cg22162597 chr1:113214053 CAPZA1 0.67 9.14 0.45 6.7e-18 Systolic blood pressure;Diastolic blood pressure;Hypertension;Blood pressure; CRC cis rs6952808 0.510 rs13227554 chr7:2048220 G/C cg21782813 chr7:2030301 MAD1L1 -0.45 -8.23 -0.41 4.4e-15 Bipolar disorder and schizophrenia; CRC trans rs2243480 1.000 rs10247526 chr7:65780696 T/G cg10756647 chr7:56101905 PSPH -0.78 -8.02 -0.4 1.83e-14 Diabetic kidney disease; CRC cis rs9914988 0.943 rs4313850 chr17:27080768 T/C cg07195577 chr17:27052828 TLCD1 0.41 5.91 0.31 8.45e-9 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs9487051 1.000 rs9487048 chr6:109615603 G/T cg01475377 chr6:109611718 NA -0.44 -7.89 -0.4 4.6e-14 Reticulocyte fraction of red cells; CRC trans rs9858542 0.953 rs11922013 chr3:49458355 G/C cg21582582 chr3:182698605 DCUN1D1 -0.51 -6.47 -0.34 3.62e-10 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs826838 1.000 rs11183941 chr12:38851692 G/C cg26384229 chr12:38710491 ALG10B 0.75 10.59 0.5 9.64e-23 Heart rate; CRC cis rs877282 0.898 rs12357995 chr10:765739 T/C cg06581033 chr10:766294 NA -0.53 -5.79 -0.3 1.61e-8 Uric acid levels; CRC cis rs7615952 0.512 rs1077621 chr3:125819799 A/G cg15145296 chr3:125709740 NA -0.56 -6.49 -0.34 3.08e-10 Blood pressure (smoking interaction); CRC cis rs9322193 0.962 rs9397357 chr6:150133601 G/A cg07701084 chr6:150067640 NUP43 0.47 6.69 0.35 9.6e-11 Lung cancer; CRC cis rs2014572 0.967 rs10413671 chr19:57763489 G/A cg24459738 chr19:57751996 ZNF805 -0.56 -8.9 -0.44 3.82e-17 Hyperactive-impulsive symptoms; CRC cis rs6089584 0.893 rs6089306 chr20:60574868 G/A cg13770153 chr20:60521292 NA -0.57 -9.66 -0.47 1.38e-19 Body mass index; CRC cis rs2996428 0.667 rs72640928 chr1:3768568 T/C cg13057898 chr1:3703894 LRRC47 0.53 6.96 0.36 1.82e-11 Red cell distribution width; CRC cis rs12476592 0.602 rs10168545 chr2:63734284 C/A cg10828910 chr2:63850056 LOC388955 0.48 5.97 0.31 6.27e-9 Childhood ear infection; CRC cis rs9443645 0.869 rs6926537 chr6:79554193 T/A cg09184832 chr6:79620586 NA -0.51 -9.73 -0.47 7.89e-20 Intelligence (multi-trait analysis); CRC cis rs9733 0.596 rs6690725 chr1:150632322 T/C cg17724175 chr1:150552817 MCL1 0.58 9.4 0.46 9.25e-19 Tonsillectomy; CRC cis rs1670533 1.000 rs2014318 chr4:1068778 C/T cg27284194 chr4:1044797 NA -0.5 -6.25 -0.33 1.31e-9 Recombination rate (females); CRC cis rs12220238 1.000 rs11000890 chr10:75904073 A/G cg19889307 chr10:75911429 ADK;AP3M1 0.61 5.92 0.31 7.99e-9 Soluble interleukin-2 receptor subunit alpha; CRC cis rs1552244 1.000 rs12374115 chr3:10134766 A/G cg16606324 chr3:10149918 C3orf24 -0.67 -9.08 -0.45 1.03e-17 Alzheimer's disease; CRC cis rs10504229 0.683 rs61306359 chr8:58134646 G/A cg02290350 chr8:58132656 NA -0.58 -8.16 -0.41 7.29e-15 Developmental language disorder (linguistic errors); CRC cis rs55788414 0.932 rs12103303 chr16:81181497 A/G cg06400318 chr16:81190750 PKD1L2 -0.58 -6.7 -0.35 9.27e-11 Left ventricular obstructive tract defect (maternal effect); CRC cis rs1867631 0.585 rs4655639 chr1:67089090 T/C cg02459107 chr1:67143332 SGIP1 0.34 6.17 0.32 1.96e-9 Menopause (age at onset); CRC cis rs12745968 0.653 rs6660136 chr1:93165207 T/A cg17283838 chr1:93427260 FAM69A -0.43 -5.85 -0.31 1.17e-8 Bipolar disorder and schizophrenia; CRC cis rs2797160 0.714 rs1777220 chr6:126022602 G/T cg05901451 chr6:126070800 HEY2 0.39 5.95 0.31 6.8e-9 Endometrial cancer; CRC cis rs10751667 0.557 rs12281858 chr11:1022187 C/T ch.11.42038R chr11:967971 AP2A2 0.56 8.77 0.44 9.87e-17 Alzheimer's disease (late onset); CRC cis rs11958404 0.860 rs6868839 chr5:157442196 T/G cg05962755 chr5:157440814 NA 1.01 12.62 0.57 4.62e-30 IgG glycosylation; CRC cis rs6500395 1.000 rs1420701 chr16:48730873 C/T cg04672837 chr16:48644449 N4BP1 -0.44 -6.52 -0.34 2.6e-10 Response to tocilizumab in rheumatoid arthritis; CRC cis rs6952808 1.000 rs12540579 chr7:1882227 C/A cg20295408 chr7:1910781 MAD1L1 -0.47 -6.76 -0.35 6.25e-11 Bipolar disorder and schizophrenia; CRC cis rs3741404 0.594 rs11231704 chr11:63898182 C/T cg05016508 chr11:63871570 FLRT1;MACROD1 -0.38 -5.74 -0.3 2.11e-8 Platelet count; CRC cis rs9322193 0.923 rs62439840 chr6:149995775 G/A cg13206674 chr6:150067644 NUP43 0.66 9.36 0.46 1.27e-18 Lung cancer; CRC cis rs2976388 0.506 rs2572902 chr8:143791387 A/G cg15511327 chr8:143859410 LYNX1 0.41 7.33 0.37 1.74e-12 Urinary tract infection frequency; CRC cis rs2243480 1.000 rs10807702 chr7:65767843 C/T cg18252515 chr7:66147081 NA -1.11 -12.34 -0.56 5.34e-29 Diabetic kidney disease; CRC trans rs9329221 0.683 rs688491 chr8:9884823 C/G cg16141378 chr3:129829833 LOC729375 0.42 6.32 0.33 8.75e-10 Neuroticism; CRC cis rs6761276 0.635 rs4849150 chr2:113830582 A/C cg24553058 chr2:113831203 IL1F10 0.42 6.6 0.34 1.6e-10 Protein quantitative trait loci; CRC cis rs11098499 0.820 rs28535956 chr4:120536858 C/T cg09307838 chr4:120376055 NA -0.68 -10.19 -0.49 2.29e-21 Corneal astigmatism; CRC cis rs4862750 0.872 rs10027252 chr4:187873462 T/G cg27532560 chr4:187881888 NA -0.54 -9.58 -0.47 2.44e-19 Lobe attachment (rater-scored or self-reported); CRC cis rs6089584 0.927 rs2281734 chr20:60582401 C/A cg13770153 chr20:60521292 NA -0.57 -9.37 -0.46 1.17e-18 Body mass index; CRC cis rs2227564 0.620 rs10740418 chr10:75519322 T/C cg00564723 chr10:75632066 CAMK2G -0.31 -7.53 -0.38 4.9e-13 Crohn's disease;Inflammatory bowel disease; CRC cis rs10949834 0.529 rs7785826 chr7:73548785 C/A cg07137043 chr7:73588983 EIF4H -0.67 -6.76 -0.35 6.2e-11 Verbal memory performance (residualized delayed recall change); CRC cis rs875971 1.000 rs811880 chr7:65818646 T/C cg11764359 chr7:65958608 NA 0.62 10.03 0.48 7.58e-21 Aortic root size; CRC cis rs10028773 0.700 rs35653026 chr4:120248378 A/G cg09307838 chr4:120376055 NA 0.64 9.48 0.46 5.15e-19 Educational attainment; CRC cis rs10927875 0.541 rs1048237 chr1:16341733 T/C cg10494257 chr1:16342123 HSPB7 0.45 6.33 0.33 7.97e-10 Dilated cardiomyopathy; CRC cis rs10782582 0.593 rs6704444 chr1:76205108 T/C cg10523679 chr1:76189770 ACADM -0.43 -6.27 -0.33 1.16e-9 Daytime sleep phenotypes; CRC trans rs561341 0.710 rs9900031 chr17:30199537 T/C cg00801512 chr17:28996047 NA 0.47 5.99 0.31 5.41e-9 Hip circumference adjusted for BMI; CRC cis rs11212617 0.902 rs599406 chr11:108118234 T/A cg14761454 chr11:108092087 ATM;NPAT 0.43 6.34 0.33 7.78e-10 Response to metformin in type 2 diabetes (glycemic); CRC cis rs202629 1 rs202629 chr22:41849975 C/T cg06634786 chr22:41940651 POLR3H 0.55 6.69 0.35 9.76e-11 Cannabis dependence symptom count; CRC cis rs9325144 0.600 rs34138871 chr12:38735261 A/G cg13010199 chr12:38710504 ALG10B 0.4 6.01 0.31 4.79e-9 Morning vs. evening chronotype; CRC cis rs875971 0.790 rs10257911 chr7:65743770 A/G cg12463550 chr7:65579703 CRCP -0.49 -6.6 -0.34 1.68e-10 Aortic root size; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg13421935 chr4:153700886 ARFIP1;TIGD4 0.44 5.99 0.31 5.35e-9 Anxiety disorder; CRC cis rs7224685 0.501 rs781848 chr17:3958105 A/C cg05562828 chr17:3906858 NA 0.69 12.44 0.57 2.25e-29 Type 2 diabetes; CRC cis rs870825 0.860 rs72689277 chr4:185593699 G/A cg04058563 chr4:185651563 MLF1IP 0.74 7.5 0.38 5.81e-13 Blood protein levels; CRC cis rs145308728 1 rs145308728 chr15:91000156 GTA/G cg04176472 chr15:90893244 GABARAPL3 0.56 7.84 0.4 6.34e-14 Lymphocyte percentage of white cells; CRC cis rs9916302 0.904 rs4795355 chr17:37427382 C/T cg00129232 chr17:37814104 STARD3 -0.55 -8.05 -0.41 1.5e-14 Glomerular filtration rate (creatinine); CRC cis rs7517126 1.000 rs56300393 chr1:196841394 G/A cg13682187 chr1:196946512 CFHR5 -0.37 -5.97 -0.31 6.03e-9 Blood protein levels; CRC cis rs17270561 0.609 rs2154218 chr6:25776290 T/C cg17691542 chr6:26056736 HIST1H1C 0.67 8.55 0.43 4.82e-16 Iron status biomarkers; CRC cis rs10089 0.951 rs1864923 chr5:127420843 G/C cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.71 9.87 0.48 2.78e-20 Ileal carcinoids; CRC cis rs13064411 0.735 rs2614191 chr3:113269201 C/T cg18753928 chr3:113234510 CCDC52 -0.49 -6.96 -0.36 1.82e-11 Response to simvastatin treatment (PCSK9 protein level change); CRC cis rs6952808 1.000 rs12540579 chr7:1882227 C/A cg22963979 chr7:1858916 MAD1L1 -0.61 -9.55 -0.47 3.17e-19 Bipolar disorder and schizophrenia; CRC cis rs2816062 0.813 rs2816053 chr1:18895819 A/G cg18795169 chr1:18902165 NA -0.92 -19.06 -0.72 4.49e-55 Urate levels in lean individuals; CRC trans rs875971 0.545 rs1796217 chr7:66085918 A/G cg02869306 chr7:64672164 INTS4L1 0.43 6.09 0.32 3.19e-9 Aortic root size; CRC cis rs34172651 0.917 rs1075987 chr16:24794957 G/A cg00339695 chr16:24857497 SLC5A11 0.26 6.01 0.31 5.01e-9 Intelligence (multi-trait analysis); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg22686022 chr17:61851232 DDX42;CCDC47 0.44 6.27 0.33 1.14e-9 Intelligence (multi-trait analysis); CRC cis rs3789045 0.774 rs11801299 chr1:204529084 G/A cg17419461 chr1:204415978 PIK3C2B -0.55 -7.75 -0.39 1.16e-13 Educational attainment (college completion); CRC cis rs12681287 0.608 rs13273338 chr8:87453361 T/G cg27223183 chr8:87520930 FAM82B -0.52 -7.44 -0.38 8.7e-13 Caudate activity during reward; CRC cis rs7927771 0.832 rs7105851 chr11:47383275 T/C cg05585544 chr11:47624801 NA 0.48 8.42 0.42 1.19e-15 Subjective well-being; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg20032723 chr11:126174041 DCPS 0.48 6.82 0.35 4.42e-11 Response to antipsychotic treatment; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg15929228 chr2:240323491 HDAC4 0.41 6.72 0.35 8.04e-11 Liver disease severity in Alagille syndrome; CRC trans rs11039798 0.588 rs3924476 chr11:48581733 T/C cg03929089 chr4:120376271 NA 0.65 7.13 0.37 6.53e-12 Axial length; CRC cis rs6840360 0.615 rs12647465 chr4:152607318 C/A cg09659197 chr4:152720779 NA 0.39 7.68 0.39 1.82e-13 Intelligence (multi-trait analysis); CRC cis rs7927592 0.913 rs11228287 chr11:68349754 A/G cg01657329 chr11:68192670 LRP5 -0.47 -6.79 -0.35 5.16e-11 Total body bone mineral density; CRC cis rs9787249 1.000 rs9787249 chr1:40212878 G/A cg02773041 chr1:40204384 PPIE 0.64 9.54 0.47 3.23e-19 Blood protein levels; CRC cis rs9322193 0.847 rs868375 chr6:150166041 T/A cg05861140 chr6:150128134 PCMT1 -0.42 -6.51 -0.34 2.77e-10 Lung cancer; CRC cis rs7917772 0.636 rs2486757 chr10:104535145 C/T cg11453585 chr10:104263688 ACTR1A;SUFU 0.68 9.88 0.48 2.57e-20 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC cis rs1799949 0.965 rs11656945 chr17:41330265 A/G cg05368731 chr17:41323189 NBR1 0.65 9.54 0.47 3.3e-19 Menopause (age at onset); CRC cis rs12908161 1.000 rs12911736 chr15:85240008 A/G cg17507749 chr15:85114479 UBE2QP1 0.62 8.83 0.44 6.36e-17 Schizophrenia; CRC cis rs3820068 0.603 rs10492986 chr1:15988702 T/C cg13390004 chr1:15929781 NA 0.53 7.26 0.37 2.78e-12 Systolic blood pressure; CRC cis rs10193935 0.901 rs7605782 chr2:42502332 C/T cg27598129 chr2:42591480 NA -0.74 -8.24 -0.41 4.27e-15 Colonoscopy-negative controls vs population controls; CRC cis rs6831352 0.918 rs13140423 chr4:100050400 T/C cg12011299 chr4:100065546 ADH4 -0.49 -9.27 -0.45 2.61e-18 Alcohol dependence; CRC cis rs977987 0.835 rs8046109 chr16:75360096 A/G cg03315344 chr16:75512273 CHST6 0.51 8.62 0.43 2.86e-16 Dupuytren's disease; CRC trans rs11825064 1.000 rs11825064 chr11:134477854 G/C cg00033773 chr19:12779366 MORG1;C19orf56 0.53 6.01 0.31 5.02e-9 Seasonality; CRC cis rs11785400 0.731 rs4294163 chr8:143730830 G/T cg10596483 chr8:143751796 JRK 0.48 6.49 0.34 3.23e-10 Schizophrenia; CRC cis rs9467711 0.606 rs13190739 chr6:26587373 G/T cg08501292 chr6:25962987 TRIM38 0.88 6.11 0.32 2.84e-9 Autism spectrum disorder or schizophrenia; CRC cis rs642858 1.000 rs6933684 chr6:140300384 C/T cg27524944 chr6:140295369 NA 0.36 6.01 0.31 5.06e-9 Type 2 diabetes; CRC cis rs77106637 0.858 rs117819392 chr11:72514503 C/T cg03713592 chr11:72463424 ARAP1 0.91 8.64 0.43 2.46e-16 Type 2 diabetes; CRC cis rs11098499 0.863 rs6835635 chr4:120458867 A/G cg24375607 chr4:120327624 NA 0.5 7.48 0.38 6.67e-13 Corneal astigmatism; CRC cis rs6764363 0.616 rs9814099 chr3:286206 A/G cg02057681 chr3:285234 CHL1 -0.41 -6.04 -0.32 4.2e-9 Sudden cardiac arrest; CRC cis rs12681287 0.752 rs4282548 chr8:87270792 A/T cg27223183 chr8:87520930 FAM82B -0.44 -5.67 -0.3 3.17e-8 Caudate activity during reward; CRC cis rs4700695 0.719 rs27084 chr5:65435286 G/A cg21114390 chr5:65439923 SFRS12 -0.63 -8.35 -0.42 1.88e-15 Facial morphology (factor 19); CRC cis rs877282 0.898 rs12354872 chr10:763362 G/A cg17470449 chr10:769945 NA 0.65 8.51 0.42 6.25e-16 Uric acid levels; CRC cis rs116095464 0.558 rs6874745 chr5:264527 A/G cg22857025 chr5:266934 NA -1.25 -16.78 -0.68 4.42e-46 Breast cancer; CRC cis rs1568889 0.838 rs12273631 chr11:28042135 A/T cg06544937 chr11:28130018 METT5D1;KIF18A 0.93 15.64 0.65 1.34e-41 Bipolar disorder; CRC cis rs4664293 0.836 rs13397597 chr2:160603595 A/T cg08347373 chr2:160653686 CD302 -0.47 -7.43 -0.38 9.32e-13 Monocyte percentage of white cells; CRC cis rs12474201 0.862 rs13025595 chr2:46977893 A/G cg06386533 chr2:46925753 SOCS5 0.76 12.57 0.57 7.19e-30 Height; CRC cis rs9488822 0.676 rs12196579 chr6:116351724 G/T cg05304507 chr6:116381966 FRK 0.32 8.87 0.44 4.84e-17 Cholesterol, total;LDL cholesterol; CRC cis rs826838 0.967 rs11183622 chr12:38792849 T/C cg26384229 chr12:38710491 ALG10B 0.75 10.46 0.5 2.69e-22 Heart rate; CRC trans rs2018683 0.707 rs2057957 chr7:28974626 A/C cg19402173 chr7:128379420 CALU 0.43 6.38 0.33 6.07e-10 Response to irinotecan and platinum-based chemotherapy in non-small-cell lung cancer; CRC trans rs61101201 0.962 rs10835790 chr11:31610022 C/T cg11781535 chr10:38893821 NA -0.53 -6.26 -0.33 1.2e-9 Optic disc area; CRC cis rs875971 1.000 rs6946143 chr7:65579722 A/C cg12463550 chr7:65579703 CRCP 0.46 6.71 0.35 8.35e-11 Aortic root size; CRC cis rs1865760 0.534 rs72834629 chr6:26023032 C/T cg16482183 chr6:26056742 HIST1H1C 0.65 8.88 0.44 4.54e-17 Height; CRC cis rs2032447 0.639 rs198810 chr6:26128618 A/G cg26028573 chr6:26043587 HIST1H2BB -0.4 -5.71 -0.3 2.59e-8 Intelligence (multi-trait analysis); CRC cis rs3785574 0.924 rs2727292 chr17:61893747 A/G cg25654072 chr17:61904446 PSMC5;FTSJ3 0.44 6.01 0.31 4.82e-9 Height; CRC cis rs172166 0.637 rs1233708 chr6:28173219 C/T cg03623178 chr6:28175578 NA 0.79 11.83 0.55 3.95e-27 Cardiac Troponin-T levels; CRC cis rs7680126 0.596 rs11731652 chr4:10292984 T/C cg11266682 chr4:10021025 SLC2A9 -0.43 -6.48 -0.34 3.28e-10 Urate levels in lean individuals;Urate levels in overweight individuals;Urate levels in obese individuals; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg17309711 chr11:45826527 SLC35C1 0.53 7.61 0.39 3.01e-13 Response to antipsychotic treatment; CRC cis rs6748734 1.000 rs4675868 chr2:241828542 A/C cg16358738 chr2:241808595 AGXT -0.39 -5.93 -0.31 7.46e-9 Urinary metabolites; CRC cis rs853679 0.550 rs1150692 chr6:28173957 A/G cg02683197 chr6:28174875 NA 0.82 11.17 0.52 8.77e-25 Depression; CRC trans rs7618501 0.633 rs9853222 chr3:50022926 T/C cg21659725 chr3:3221576 CRBN 0.61 9.54 0.47 3.42e-19 Intelligence (multi-trait analysis); CRC cis rs951366 0.646 rs1772159 chr1:205759195 G/A cg07157834 chr1:205819609 PM20D1 0.92 14.69 0.63 6.51e-38 Menarche (age at onset); CRC cis rs6964587 0.869 rs7793946 chr7:91520628 T/C cg17063962 chr7:91808500 NA -0.72 -11.8 -0.55 4.72e-27 Breast cancer; CRC cis rs12477438 0.520 rs11695751 chr2:99708247 A/C cg14399236 chr2:99771627 LIPT1;TSGA10 0.83 14.59 0.63 1.51e-37 Chronic sinus infection; CRC cis rs10760158 0.832 rs10760164 chr9:124011162 C/T cg14417974 chr9:124058376 GSN -0.34 -5.7 -0.3 2.62e-8 Pulse pressure; CRC trans rs12432203 1.000 rs72622439 chr14:51736948 C/A cg14592830 chr9:122318704 NA 0.58 6.0 0.31 5.07e-9 Cancer; CRC cis rs4423214 0.625 rs78685409 chr11:71137383 T/C cg13043300 chr11:71146211 DHCR7 -0.46 -6.2 -0.32 1.73e-9 Vitamin D levels; CRC cis rs11785400 1.000 rs9720653 chr8:143731939 T/G cg10596483 chr8:143751796 JRK 0.5 7.1 0.36 7.85e-12 Schizophrenia; CRC cis rs9303401 0.659 rs62081314 chr17:56778328 A/G cg02118635 chr17:56770003 RAD51C;TEX14 0.79 10.13 0.49 3.5e-21 Cognitive test performance; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg25466368 chr3:193853978 HES1 0.46 6.98 0.36 1.59e-11 Intelligence (multi-trait analysis); CRC cis rs4713118 0.547 rs2116981 chr6:28067951 T/G cg03623178 chr6:28175578 NA 0.95 12.46 0.57 1.93e-29 Parkinson's disease; CRC cis rs2228479 0.541 rs12918575 chr16:89811151 A/G cg19635926 chr16:89946313 TCF25 0.57 5.96 0.31 6.58e-9 Skin colour saturation; CRC cis rs9611565 0.649 rs202666 chr22:41814719 T/C cg06634786 chr22:41940651 POLR3H 0.62 7.12 0.37 6.85e-12 Vitiligo; CRC cis rs34375054 0.738 rs10773145 chr12:125625603 C/T cg02766259 chr12:125626809 AACS 0.41 7.83 0.4 6.74e-14 Post bronchodilator FEV1/FVC ratio; CRC cis rs9527 0.615 rs4919685 chr10:104587362 G/T cg04362960 chr10:104952993 NT5C2 0.64 8.13 0.41 8.69e-15 Arsenic metabolism; CRC cis rs7771547 0.573 rs566742 chr6:36395668 C/T cg07856975 chr6:36356162 ETV7 0.4 5.86 0.31 1.12e-8 Platelet distribution width; CRC cis rs12541335 0.639 rs11135995 chr8:22200148 C/T cg02788857 chr8:22132959 PIWIL2 -0.48 -8.24 -0.41 4.08e-15 Hypertriglyceridemia; CRC trans rs11148252 0.904 rs7321964 chr13:53040822 A/G cg18335740 chr13:41363409 SLC25A15 0.63 10.04 0.48 7.43e-21 Lewy body disease; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg22557350 chr10:126432983 FAM53B 0.43 6.18 0.32 1.93e-9 Response to antipsychotic treatment; CRC trans rs941408 1.000 rs1640271 chr19:2799979 C/T cg19676328 chr12:49525230 TUBA1B -0.66 -10.63 -0.51 6.8e-23 Total cholesterol levels; CRC cis rs1395 0.744 rs11686131 chr2:27508710 C/T cg23587288 chr2:27483067 SLC30A3 -0.44 -6.54 -0.34 2.36e-10 Blood metabolite levels; CRC cis rs7394190 0.630 rs113799665 chr10:75575138 C/T cg07699608 chr10:75541558 CHCHD1 0.58 5.82 0.31 1.41e-8 Incident atrial fibrillation; CRC cis rs7692995 1.000 rs7696532 chr4:18029299 C/T cg08925142 chr4:18023851 LCORL -0.53 -5.98 -0.31 5.94e-9 Height; CRC cis rs67311347 0.544 rs7652439 chr3:40349948 G/T cg09455208 chr3:40491958 NA 0.29 5.62 0.3 4.14e-8 Renal cell carcinoma; CRC cis rs995000 0.895 rs783291 chr1:62914978 G/A cg19896129 chr1:63156450 NA 0.43 6.59 0.34 1.75e-10 Triglyceride levels; CRC cis rs709400 1.000 rs58133129 chr14:104104759 A/G cg12935359 chr14:103987150 CKB -0.39 -6.44 -0.33 4.13e-10 Body mass index; CRC cis rs10504229 0.593 rs79874994 chr8:57993709 C/A cg11062466 chr8:58055876 NA 0.49 5.88 0.31 1e-8 Developmental language disorder (linguistic errors); CRC cis rs3785574 0.962 rs2665835 chr17:61903258 C/T cg11494091 chr17:61959527 GH2 0.37 5.66 0.3 3.34e-8 Height; CRC cis rs72627123 0.656 rs6574169 chr14:74637178 G/A cg12022184 chr14:74485813 ENTPD5;C14orf45 -0.72 -5.67 -0.3 3.06e-8 Morning vs. evening chronotype; CRC cis rs7552404 1.000 rs4949875 chr1:76173080 G/A cg10523679 chr1:76189770 ACADM 0.83 11.25 0.53 4.54e-25 Blood metabolite levels;Acylcarnitine levels; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg17114402 chr2:97778470 ANKRD36 0.47 7.34 0.38 1.66e-12 Liver disease severity in Alagille syndrome; CRC cis rs1538970 0.962 rs4660849 chr1:45819872 A/G cg05343316 chr1:45956843 TESK2 -0.69 -9.34 -0.46 1.55e-18 Platelet count; CRC cis rs9443645 0.901 rs2174742 chr6:79610101 G/T cg05283184 chr6:79620031 NA -0.58 -9.24 -0.45 3.18e-18 Intelligence (multi-trait analysis); CRC cis rs6952808 0.792 rs12531315 chr7:1953650 C/G cg02951883 chr7:2050386 MAD1L1 -0.69 -10.95 -0.52 5.26e-24 Bipolar disorder and schizophrenia; CRC cis rs941873 0.836 rs6480931 chr10:81108482 T/C cg09469691 chr10:81107165 PPIF 0.53 8.36 0.42 1.76e-15 Height; CRC cis rs2576037 0.583 rs11659693 chr18:44458733 C/T cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.56 -8.81 -0.44 7.5e-17 Personality dimensions; CRC cis rs775227 0.574 rs36108475 chr3:113038406 C/T cg18753928 chr3:113234510 CCDC52 -0.55 -6.82 -0.35 4.44e-11 Dental caries; CRC cis rs995000 0.839 rs1168028 chr1:62969431 G/A cg19896129 chr1:63156450 NA -0.39 -6.08 -0.32 3.29e-9 Triglyceride levels; CRC cis rs4474465 1.000 rs7950813 chr11:78215082 A/T cg27205649 chr11:78285834 NARS2 0.48 6.06 0.32 3.81e-9 Alzheimer's disease (survival time); CRC cis rs3749237 0.964 rs13084243 chr3:49821878 G/C cg24308560 chr3:49941425 MST1R -0.42 -5.93 -0.31 7.5e-9 Resting heart rate; CRC cis rs7647973 1.000 rs3870341 chr3:49584745 A/G cg07690219 chr3:49449608 TCTA;RHOA -0.54 -6.34 -0.33 7.58e-10 Menarche (age at onset); CRC cis rs514406 0.825 rs6693210 chr1:53223398 A/G cg08859206 chr1:53392774 SCP2 0.42 6.56 0.34 2.14e-10 Monocyte count; CRC cis rs12824058 0.799 rs4759656 chr12:130815804 G/A cg26677194 chr12:130822605 PIWIL1 0.45 7.42 0.38 9.93e-13 Menopause (age at onset); CRC cis rs11711311 0.955 rs12634241 chr3:113397685 T/C cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.51 -6.81 -0.35 4.76e-11 IgG glycosylation; CRC cis rs6570726 0.967 rs403584 chr6:145807010 G/A cg05347473 chr6:146136440 FBXO30 0.37 5.8 0.3 1.58e-8 Lobe attachment (rater-scored or self-reported); CRC cis rs4547160 1.000 rs4547160 chr12:63503650 A/C cg26727693 chr12:63544175 AVPR1A 0.41 8.22 0.41 4.7e-15 Morning vs. evening chronotype; CRC cis rs739401 0.527 rs423236 chr11:3065916 C/T cg08508325 chr11:3079039 CARS -0.52 -9.42 -0.46 8.25e-19 Longevity; CRC cis rs17152411 0.895 rs11245418 chr10:126586319 T/C cg07906193 chr10:126599966 NA 0.56 6.33 0.33 7.97e-10 Height; CRC cis rs34172651 0.517 rs200526 chr16:24760511 C/T cg00339695 chr16:24857497 SLC5A11 -0.44 -9.1 -0.45 8.59e-18 Intelligence (multi-trait analysis); CRC cis rs9381040 0.610 rs9357345 chr6:41025118 G/C cg25110423 chr6:41068646 NFYA;LOC221442 -0.38 -5.77 -0.3 1.79e-8 Alzheimer's disease (late onset); CRC cis rs11785400 0.762 rs4401833 chr8:143739731 A/T cg10596483 chr8:143751796 JRK 0.44 5.88 0.31 9.91e-9 Schizophrenia; CRC cis rs172166 0.694 rs1150666 chr6:28123928 T/C cg12172441 chr6:28176163 NA 0.54 7.31 0.37 2.06e-12 Cardiac Troponin-T levels; CRC cis rs875971 0.545 rs67775320 chr7:65658779 T/C cg05627663 chr7:65219948 SNORA22;CCT6P1 0.61 8.03 0.4 1.78e-14 Aortic root size; CRC cis rs2739330 0.828 rs5760107 chr22:24252597 T/C cg04234412 chr22:24373322 LOC391322 -0.7 -11.27 -0.53 3.81e-25 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs116095464 0.558 rs6866776 chr5:264495 C/T cg22496380 chr5:211416 CCDC127 -0.91 -10.46 -0.5 2.65e-22 Breast cancer; CRC cis rs2230307 0.536 rs2893426 chr1:100528200 G/T cg24955406 chr1:100503596 HIAT1 0.58 7.15 0.37 5.76e-12 Carotid intima media thickness; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg15959262 chr8:102381107 NACAP1 -0.38 -6.06 -0.32 3.76e-9 Liver disease severity in Alagille syndrome; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg01392097 chr7:101331643 NA 0.49 6.97 0.36 1.72e-11 Response to antipsychotic treatment; CRC cis rs10982256 0.567 rs1000709 chr9:117237754 C/T cg13636371 chr9:117264095 DFNB31 0.32 6.16 0.32 2.13e-9 Bipolar disorder; CRC cis rs10493773 0.609 rs11161656 chr1:86182414 A/G cg17807903 chr1:86174739 ZNHIT6 -0.64 -17.36 -0.69 2.23e-48 Urate levels in overweight individuals; CRC cis rs4688759 0.764 rs11716961 chr3:49908338 G/A cg00383909 chr3:49044727 WDR6 1.38 10.23 0.49 1.67e-21 Blood protein levels; CRC trans rs703108 0.731 rs7898954 chr10:22323646 A/G cg11215015 chr1:197116161 ASPM -0.6 -7.68 -0.39 1.89e-13 Monocyte percentage of white cells; CRC trans rs5756813 0.754 rs15691 chr22:38172380 C/A cg19894588 chr14:64061835 NA -0.58 -7.8 -0.4 8.15e-14 Optic cup area;Vertical cup-disc ratio; CRC cis rs6502050 0.835 rs4789668 chr17:80161990 C/T cg19223190 chr17:80058835 NA 0.43 6.82 0.35 4.37e-11 Life satisfaction; CRC cis rs7927771 0.524 rs7929014 chr11:47776283 C/T cg20307385 chr11:47447363 PSMC3 0.45 6.57 0.34 1.92e-10 Subjective well-being; CRC trans rs208520 0.874 rs208481 chr6:66922636 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.91 -11.82 -0.55 3.98e-27 Exhaled nitric oxide output; CRC cis rs4237845 0.611 rs7978588 chr12:58304783 G/C cg02175503 chr12:58329896 NA 0.79 12.45 0.57 2.12e-29 Intelligence (multi-trait analysis); CRC cis rs9894429 0.550 rs6565617 chr17:79612333 G/A cg18240062 chr17:79603768 NPLOC4 0.47 7.42 0.38 1.02e-12 Eye color traits; CRC trans rs925098 0.577 rs2724470 chr4:17996046 A/G cg04981696 chr16:16044519 ABCC1 -0.46 -6.63 -0.34 1.34e-10 Birth weight;Height; CRC cis rs7781266 0.947 rs2542264 chr7:133480664 C/T cg03336402 chr7:133662267 EXOC4 -0.55 -7.15 -0.37 5.66e-12 Educational attainment (college completion); CRC trans rs1584120 0.830 rs7315662 chr12:23514531 T/C cg15904523 chr19:44763979 ZNF233 -0.42 -5.98 -0.31 5.84e-9 Pelvic organ prolapse (moderate/severe); CRC trans rs7395662 0.892 rs11040010 chr11:48776929 G/T cg21153622 chr11:89784906 NA 0.46 7.39 0.38 1.26e-12 HDL cholesterol; CRC cis rs10927875 0.722 rs1763606 chr1:16338282 A/G cg10494257 chr1:16342123 HSPB7 0.45 6.0 0.31 5.3e-9 Dilated cardiomyopathy; CRC cis rs2224391 1.000 rs9784870 chr6:5261359 A/G cg26165608 chr6:5261829 LYRM4;FARS2 -0.45 -5.66 -0.3 3.23e-8 Height; CRC cis rs2398893 0.889 rs7870790 chr9:96779553 G/A cg14459158 chr9:96720562 NA 0.42 6.82 0.35 4.47e-11 Waist-hip ratio;Waist-to-hip ratio adjusted for body mass index; CRC trans rs9291683 0.546 rs10939672 chr4:10052136 A/G cg26043149 chr18:55253948 FECH 0.53 8.03 0.4 1.78e-14 Bone mineral density; CRC cis rs7727544 0.548 rs4705938 chr5:131694077 A/G cg02033258 chr5:131593261 PDLIM4 0.34 6.32 0.33 8.36e-10 Blood metabolite levels; CRC cis rs877282 0.755 rs2486578 chr10:785227 C/T cg17470449 chr10:769945 NA -0.44 -6.33 -0.33 7.84e-10 Uric acid levels; CRC cis rs6942756 1.000 rs7806089 chr7:128972215 C/G cg02491457 chr7:128862824 NA -0.75 -10.04 -0.48 7.2e-21 White matter hyperintensity burden; CRC cis rs4555082 0.874 rs2142190 chr14:105719306 G/A cg13114125 chr14:105738426 BRF1 -0.85 -12.44 -0.57 2.23e-29 Mean platelet volume;Platelet distribution width; CRC cis rs9814567 0.929 rs9855013 chr3:134240414 C/T cg06109529 chr3:134205091 CEP63;ANAPC13 -0.81 -12.19 -0.56 1.92e-28 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs6701037 0.748 rs11585368 chr1:175135448 G/A cg14847009 chr1:175162515 KIAA0040 -0.26 -5.68 -0.3 2.89e-8 Alcohol dependence; CRC trans rs1814175 0.645 rs10444311 chr11:49986906 A/G cg11707556 chr5:10655725 ANKRD33B -0.52 -10.05 -0.48 6.61e-21 Height; CRC cis rs11677416 1.000 rs6542090 chr2:113524795 T/C cg27083787 chr2:113543245 IL1A 0.45 6.47 0.34 3.5e-10 Response to antipsychotic treatment in schizophrenia (working memory); CRC cis rs3768617 0.510 rs3765522 chr1:183077618 C/T ch.1.3577855R chr1:183094577 LAMC1 0.87 15.53 0.65 3.62e-41 Fuchs's corneal dystrophy; CRC cis rs875971 0.965 rs10267430 chr7:65743023 G/T cg11764359 chr7:65958608 NA -0.61 -9.83 -0.48 3.71e-20 Aortic root size; CRC cis rs1950626 0.699 rs12880424 chr14:101459660 C/T cg02351406 chr14:101447389 SNORD114-20;SNORD114-21 0.98 15.9 0.66 1.28e-42 Pelvic organ prolapse (moderate/severe); CRC cis rs4970966 0.951 rs6665912 chr1:150544093 T/C cg17724175 chr1:150552817 MCL1 -0.48 -5.87 -0.31 1.08e-8 Granulocyte percentage of myeloid white cells;Monocyte count;Monocyte percentage of white cells; CRC cis rs7917772 0.502 rs4919670 chr10:104515799 C/A cg22532475 chr10:104410764 TRIM8 0.32 5.66 0.3 3.34e-8 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC cis rs7666738 0.830 rs4699590 chr4:98974030 A/C cg17366294 chr4:99064904 C4orf37 0.44 7.37 0.38 1.43e-12 Colonoscopy-negative controls vs population controls; CRC cis rs6502050 0.769 rs9904237 chr17:80119664 G/A cg13198984 chr17:80129470 CCDC57 0.47 8.35 0.42 1.88e-15 Life satisfaction; CRC cis rs910316 1.000 rs12589376 chr14:75561152 C/T cg08847533 chr14:75593920 NEK9 0.93 17.78 0.7 4.82e-50 Height; CRC cis rs1552244 0.554 rs2272118 chr3:10049287 T/C cg18598329 chr3:10140678 FANCD2;C3orf24 -0.54 -7.67 -0.39 1.98e-13 Alzheimer's disease; CRC cis rs2288073 0.965 rs10185445 chr2:24410976 A/C cg06627628 chr2:24431161 ITSN2 0.7 9.8 0.48 4.69e-20 Venous thromboembolism (SNP x SNP interaction); CRC cis rs728616 0.681 rs17100316 chr10:81913337 A/G cg05935833 chr10:81318306 SFTPA2 -0.49 -5.85 -0.31 1.21e-8 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs3768617 0.510 rs12095664 chr1:183101686 G/A ch.1.3577855R chr1:183094577 LAMC1 0.89 15.86 0.66 1.84e-42 Fuchs's corneal dystrophy; CRC cis rs3785574 1.000 rs7223257 chr17:61787684 T/C cg23090583 chr17:61904693 PSMC5;FTSJ3 0.64 9.34 0.46 1.46e-18 Height; CRC cis rs9916302 0.861 rs632202 chr17:37453294 C/A cg00129232 chr17:37814104 STARD3 0.55 8.19 0.41 5.68e-15 Glomerular filtration rate (creatinine); CRC trans rs7395662 0.504 rs1814158 chr11:48437937 C/T cg21153622 chr11:89784906 NA -0.5 -8.42 -0.42 1.19e-15 HDL cholesterol; CRC cis rs34779708 0.931 rs11597392 chr10:35288575 T/C cg03585969 chr10:35415529 CREM 0.65 8.64 0.43 2.4e-16 Inflammatory bowel disease;Crohn's disease; CRC cis rs10751667 0.643 rs7396623 chr11:934104 G/A cg01483505 chr11:975446 AP2A2 0.45 7.28 0.37 2.52e-12 Alzheimer's disease (late onset); CRC cis rs11628318 0.614 rs3825565 chr14:103060465 G/A cg08075719 chr14:103021372 NA -0.68 -7.93 -0.4 3.47e-14 Platelet count; CRC cis rs7192380 0.639 rs12448486 chr16:69802878 G/A cg00738113 chr16:70207722 CLEC18C 0.47 8.1 0.41 1.11e-14 Sjögren's syndrome; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg27662123 chr14:100842884 WARS;WDR25 0.45 6.43 0.33 4.44e-10 Anxiety disorder; CRC cis rs2274273 0.648 rs58553156 chr14:55582694 T/A cg10130446 chr14:55658398 DLGAP5 -0.44 -6.16 -0.32 2.09e-9 Protein biomarker; CRC cis rs13108904 0.560 rs11247994 chr4:1343720 G/A cg00684032 chr4:1343700 KIAA1530 0.61 8.62 0.43 2.96e-16 Obesity-related traits; CRC cis rs10924970 0.967 rs4659678 chr1:235396697 A/G cg26050004 chr1:235667680 B3GALNT2 0.39 5.78 0.3 1.71e-8 Asthma; CRC cis rs28456 1 rs28456 chr11:61589481 A/G cg00603274 chr11:61596626 FADS2 -0.47 -6.59 -0.34 1.72e-10 Bipolar disorder; CRC cis rs9463078 0.845 rs9369514 chr6:44797271 C/A cg25276700 chr6:44698697 NA -0.25 -6.08 -0.32 3.4e-9 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; CRC cis rs526821 0.595 rs517627 chr11:55356489 C/T cg04317927 chr11:55418816 OR4S2 0.4 6.85 0.35 3.57e-11 Pediatric bone mineral density (spine); CRC cis rs902774 0.818 rs17120257 chr12:53303331 T/C cg16329197 chr12:53359506 NA -0.54 -5.77 -0.3 1.8e-8 Prostate cancer; CRC trans rs2797160 0.967 rs2797162 chr6:126011381 G/T cg05039488 chr6:79577232 IRAK1BP1 0.49 7.29 0.37 2.25e-12 Endometrial cancer; CRC cis rs10486722 0.603 rs10279802 chr7:41774169 G/A cg22138096 chr7:41772439 LOC285954 0.38 5.8 0.3 1.54e-8 Pit-and-Fissure caries; CRC cis rs10883723 0.810 rs2296590 chr10:104262628 G/A cg22532475 chr10:104410764 TRIM8 -0.37 -6.86 -0.35 3.51e-11 Allergic disease (asthma, hay fever or eczema); CRC cis rs4820539 0.966 rs5751590 chr22:23486830 A/C cg14186256 chr22:23484241 RTDR1 0.91 17.41 0.69 1.38e-48 Bone mineral density; CRC cis rs1448094 0.791 rs10863124 chr12:86352548 A/T cg25456477 chr12:86230367 RASSF9 0.34 5.81 0.31 1.46e-8 Major depressive disorder; CRC cis rs362272 0.505 rs60208975 chr4:3364530 A/G cg16416165 chr4:3325029 RGS12 0.39 5.77 0.3 1.85e-8 Serum sulfate level; CRC cis rs62158211 0.691 rs1964463 chr2:114069021 C/T cg17784749 chr2:114082611 LOC440839 -0.49 -5.94 -0.31 7.24e-9 Sleep duration (oversleepers vs undersleepers);Sleep traits (multi-trait analysis);Sleep duration; CRC cis rs8114671 0.562 rs6087653 chr20:33522054 T/C cg07148914 chr20:33460835 GGT7 0.4 6.65 0.34 1.21e-10 Height; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg00287636 chr16:49892218 NA -0.38 -6.7 -0.35 9.32e-11 Myopia (pathological); CRC trans rs2821260 0.902 rs12131816 chr1:72529866 A/G cg18779060 chr21:38740667 DYRK1A -0.48 -6.02 -0.31 4.7e-9 Intelligence (multi-trait analysis); CRC trans rs10982213 0.830 rs2274163 chr9:117188714 C/T cg00267196 chr8:135710113 ZFAT 0.44 6.49 0.34 3.07e-10 Interleukin-6 levels; CRC cis rs6860806 0.531 rs272887 chr5:131665713 A/G cg18301423 chr5:131593218 PDLIM4 0.37 6.14 0.32 2.36e-9 Breast cancer; CRC cis rs11122272 0.735 rs2295420 chr1:231485640 C/T cg06096015 chr1:231504339 EGLN1 0.41 6.22 0.32 1.52e-9 Hemoglobin concentration; CRC cis rs1983170 0.778 rs906241 chr1:92012154 G/T cg02896835 chr1:92012615 NA -0.51 -7.16 -0.37 5.23e-12 Eosinophil percentage of white cells; CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg11611950 chr6:24667276 ACOT13;TTRAP 0.37 6.16 0.32 2.16e-9 Obesity-related traits; CRC cis rs12369179 0.737 rs116896792 chr12:122948907 T/C cg18578876 chr12:123200353 GPR109B -1.12 -8.94 -0.44 2.92e-17 Age-related diseases, mortality and associated endophenotypes;Age-related disease endophenotypes; CRC cis rs2303759 0.881 rs10412811 chr19:49884495 G/A cg22307029 chr19:49891270 CCDC155 0.7 9.89 0.48 2.25e-20 Multiple sclerosis; CRC cis rs12701220 0.894 rs12539012 chr7:1052133 G/A cg02733842 chr7:1102375 C7orf50 -0.83 -9.99 -0.48 1.05e-20 Bronchopulmonary dysplasia; CRC cis rs861020 0.710 rs7516902 chr1:210022179 A/G cg09163369 chr1:210001066 C1orf107 0.61 8.08 0.41 1.22e-14 Orofacial clefts; CRC cis rs7173389 0.551 rs11638230 chr15:73656261 G/A cg01796676 chr15:73680284 NA 0.62 5.9 0.31 8.94e-9 Resting heart rate; CRC cis rs11583043 0.918 rs58029001 chr1:101393409 A/G cg00063077 chr1:101360652 SLC30A7;EXTL2 0.5 6.76 0.35 6.34e-11 Ulcerative colitis;Inflammatory bowel disease; CRC cis rs6867032 0.958 rs4975797 chr5:2015573 G/A cg26168224 chr5:2018326 NA 1.0 18.55 0.71 4.56e-53 Gut microbiome composition (winter); CRC cis rs7927592 0.913 rs7925275 chr11:68290433 T/C cg01657329 chr11:68192670 LRP5 -0.46 -6.56 -0.34 2.06e-10 Total body bone mineral density; CRC cis rs2286885 1.000 rs1537987 chr9:129242112 T/C cg15282417 chr9:129245246 FAM125B 0.44 8.09 0.41 1.18e-14 Intraocular pressure; CRC cis rs1799949 1.000 rs11654452 chr17:41189383 G/T cg25072359 chr17:41440525 NA 0.47 6.92 0.36 2.32e-11 Menopause (age at onset); CRC cis rs2239547 0.522 rs4519686 chr3:52997871 C/T cg10802521 chr3:52805072 NEK4 -0.46 -6.34 -0.33 7.51e-10 Schizophrenia; CRC cis rs694739 0.894 rs887314 chr11:64053157 T/G cg23796481 chr11:64053134 BAD;GPR137 0.58 8.46 0.42 8.96e-16 Alopecia areata;Crohn's disease;Psoriasis vulgaris; CRC cis rs1003719 0.680 rs2835629 chr21:38521660 A/T cg10648535 chr21:38446584 PIGP;TTC3 -0.48 -6.63 -0.34 1.39e-10 Eye color traits; CRC cis rs6860806 0.661 rs6890009 chr5:131580033 G/T cg02033258 chr5:131593261 PDLIM4 0.4 7.69 0.39 1.69e-13 Breast cancer; CRC cis rs8072100 0.967 rs4338849 chr17:45512483 A/G cg25173405 chr17:45401733 C17orf57 -0.51 -8.05 -0.41 1.48e-14 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs2991971 0.967 rs12133294 chr1:45988764 C/T cg15605315 chr1:45957053 TESK2 0.43 6.77 0.35 5.89e-11 High light scatter reticulocyte count; CRC cis rs9368481 0.569 rs6907403 chr6:26877297 A/C cg05192639 chr6:26864778 GUSBL1 0.33 5.9 0.31 8.99e-9 Autism spectrum disorder or schizophrenia; CRC cis rs6968419 0.585 rs10953816 chr7:115918527 A/G cg19719915 chr7:115928094 NA 0.4 6.58 0.34 1.84e-10 Intraocular pressure; CRC cis rs79349575 0.783 rs15563 chr17:47005193 A/G cg22482690 chr17:47019901 SNF8 0.48 8.17 0.41 6.49e-15 Type 2 diabetes; CRC cis rs9303401 0.614 rs12948536 chr17:56580413 G/T cg02118635 chr17:56770003 RAD51C;TEX14 0.78 9.7 0.47 1.02e-19 Cognitive test performance; CRC cis rs4409675 0.576 rs3766396 chr1:28221554 C/T cg23691781 chr1:28212827 C1orf38 -0.34 -7.83 -0.4 6.66e-14 Corneal astigmatism; CRC cis rs921968 0.509 rs556468 chr2:219355794 G/A cg02176678 chr2:219576539 TTLL4 0.54 8.69 0.43 1.78e-16 Mean corpuscular hemoglobin concentration; CRC cis rs1577917 0.958 rs7453105 chr6:86500761 A/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.52 -6.88 -0.35 2.95e-11 Response to antipsychotic treatment; CRC cis rs2795502 1.000 rs2795496 chr10:43337842 G/A cg20628663 chr10:43360327 NA -0.69 -10.73 -0.51 3.19e-23 Blood protein levels; CRC cis rs67311347 1.000 rs112619360 chr3:40432645 T/G cg17687789 chr3:40543613 NA 0.3 5.62 0.3 4.15e-8 Renal cell carcinoma; CRC cis rs8077889 0.956 rs4793026 chr17:41850508 A/G cg16892393 chr17:41919603 NA 0.4 6.04 0.32 4.08e-9 Triglycerides; CRC cis rs2996428 0.667 rs7538067 chr1:3761772 C/T cg13057898 chr1:3703894 LRRC47 0.53 6.99 0.36 1.53e-11 Red cell distribution width; CRC cis rs6912958 0.630 rs9450726 chr6:88236728 A/G cg08069147 chr6:88032118 GJB7;C6orf162 -0.48 -7.29 -0.37 2.25e-12 Monocyte percentage of white cells; CRC trans rs1455244 0.700 rs7229302 chr18:11508904 G/T cg24543526 chr10:75911479 ADK;AP3M1 0.42 6.32 0.33 8.67e-10 Schizophrenia; CRC cis rs9826463 0.757 rs73240316 chr3:142266061 A/G cg20824294 chr3:142316082 PLS1 0.42 7.06 0.36 1.01e-11 QRS duration in Tripanosoma cruzi seropositivity; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg27209983 chr11:124824125 CCDC15 0.43 6.03 0.32 4.43e-9 Response to antipsychotic treatment; CRC trans rs1814175 0.533 rs4528310 chr11:49983106 C/A cg15704280 chr7:45808275 SEPT13 -0.94 -16.88 -0.68 1.75e-46 Height; CRC cis rs478304 0.934 rs603645 chr11:65533000 A/C cg27068330 chr11:65405492 SIPA1 0.44 6.55 0.34 2.26e-10 Acne (severe); CRC cis rs77633900 0.614 rs280012 chr15:76974854 G/T cg21673338 chr15:77095150 SCAPER -0.75 -7.82 -0.4 7.28e-14 Non-glioblastoma glioma;Glioma; CRC cis rs7208859 0.673 rs3764420 chr17:29164154 A/G cg13385521 chr17:29058706 SUZ12P 0.69 8.07 0.41 1.34e-14 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs12188164 0.543 rs2672757 chr5:454732 A/G cg26850624 chr5:429559 AHRR 0.52 8.8 0.44 8.1e-17 Cystic fibrosis severity; CRC cis rs853679 0.517 rs4713137 chr6:28083521 C/G cg12963246 chr6:28129442 ZNF389 0.5 5.8 0.3 1.53e-8 Depression; CRC cis rs10540 0.558 rs12806062 chr11:501429 G/A cg15790184 chr11:494944 RNH1 0.67 6.63 0.34 1.34e-10 Body mass index; CRC cis rs2832191 1.000 rs2832185 chr21:30483761 C/G cg24692254 chr21:30365293 RNF160 -0.65 -11.18 -0.52 8.29e-25 Dental caries; CRC cis rs8062405 0.965 rs56040780 chr16:28861881 C/T cg16576597 chr16:28551801 NUPR1 0.48 6.83 0.35 4.14e-11 Cognitive ability (multi-trait analysis);Cognitive ability; CRC cis rs8038465 0.622 rs17185525 chr15:73885539 T/C cg15420318 chr15:73925796 NPTN 0.45 7.27 0.37 2.67e-12 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs870825 0.616 rs2141258 chr4:185609576 A/C cg07424746 chr4:185654737 MLF1IP 0.54 5.7 0.3 2.74e-8 Blood protein levels; CRC cis rs6570726 0.935 rs429306 chr6:145827016 T/C cg05347473 chr6:146136440 FBXO30 0.37 6.0 0.31 5.27e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs875971 0.928 rs2036263 chr7:65800197 C/T cg18876405 chr7:65276391 NA -0.52 -8.56 -0.43 4.45e-16 Aortic root size; CRC cis rs55788414 0.932 rs28583467 chr16:81186428 G/C cg06400318 chr16:81190750 PKD1L2 -0.6 -7.04 -0.36 1.11e-11 Left ventricular obstructive tract defect (maternal effect); CRC cis rs6585424 1.000 rs11201966 chr10:81931780 T/C cg11900509 chr10:81946545 ANXA11 -0.72 -8.84 -0.44 5.72e-17 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs9549367 0.789 rs2302754 chr13:113898385 C/T cg00898013 chr13:113819073 PROZ 0.44 6.18 0.32 1.89e-9 Platelet distribution width; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg22112460 chr1:32688107 C1orf91;EIF3I 0.46 6.54 0.34 2.32e-10 Response to antipsychotic treatment; CRC cis rs2836974 0.568 rs371625 chr21:40535271 A/G cg22974920 chr21:40686053 BRWD1 -0.42 -6.0 -0.31 5.34e-9 Cognitive function; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg02220365 chr11:67211717 CORO1B 0.37 6.31 0.33 8.82e-10 Liver disease severity in Alagille syndrome; CRC trans rs6600671 1.000 rs12047116 chr1:121185770 G/A cg00646200 chr1:148855367 NA 0.34 6.2 0.32 1.72e-9 Hip geometry; CRC cis rs66569888 0.754 rs6719028 chr2:106895212 T/C cg15412446 chr2:106886593 NA 0.67 10.48 0.5 2.21e-22 Facial morphology (factor 23); CRC cis rs13108904 0.901 rs12641735 chr4:1304434 G/C cg16405210 chr4:1374714 KIAA1530 -0.42 -5.96 -0.31 6.33e-9 Obesity-related traits; CRC cis rs2243480 0.803 rs13224048 chr7:65993766 G/A cg12463550 chr7:65579703 CRCP 0.68 6.17 0.32 2.02e-9 Diabetic kidney disease; CRC cis rs9788333 0.962 rs12584792 chr13:21887208 C/T cg21970626 chr13:21893289 NA -0.45 -8.37 -0.42 1.65e-15 Thiazide-induced adverse metabolic effects in hypertensive patients; CRC cis rs2197308 0.619 rs4002730 chr12:37876400 T/C cg26384229 chr12:38710491 ALG10B 0.67 8.79 0.44 8.51e-17 Morning vs. evening chronotype; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg23740310 chr12:12878752 APOLD1 0.45 6.12 0.32 2.6e-9 Response to antipsychotic treatment; CRC cis rs35740288 0.862 rs11637444 chr15:86311188 G/A cg20737812 chr15:86336631 KLHL25 -0.36 -5.61 -0.3 4.28e-8 Eosinophil percentage of white cells;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg00371891 chr19:4723959 DPP9 0.45 6.29 0.33 1.03e-9 Response to antipsychotic treatment; CRC cis rs3785574 0.962 rs16947051 chr17:61790917 G/C cg23090583 chr17:61904693 PSMC5;FTSJ3 0.64 9.28 0.46 2.35e-18 Height; CRC cis rs66573146 1.000 rs73202122 chr4:7005594 G/A cg00086871 chr4:6988644 TBC1D14 1.0 6.66 0.34 1.14e-10 Granulocyte percentage of myeloid white cells; CRC cis rs875971 0.545 rs10950025 chr7:65623933 G/A cg05627663 chr7:65219948 SNORA22;CCT6P1 0.6 7.73 0.39 1.29e-13 Aortic root size; CRC cis rs1451375 0.617 rs2329371 chr7:50615440 G/A cg14593290 chr7:50529359 DDC 0.64 8.47 0.42 8.37e-16 Malaria; CRC cis rs4242434 0.927 rs11136093 chr8:22479988 C/G cg03733263 chr8:22462867 KIAA1967 1.04 18.34 0.71 3.05e-52 Exploratory eye movement dysfunction in schizophrenia (cognitive search score); CRC cis rs780096 0.546 rs715325 chr2:27725572 C/A cg24768116 chr2:27665128 KRTCAP3 -0.34 -7.75 -0.39 1.17e-13 Total body bone mineral density; CRC cis rs1003719 0.591 rs1053984 chr21:38574018 C/T cg10648535 chr21:38446584 PIGP;TTC3 -0.42 -5.95 -0.31 6.96e-9 Eye color traits; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg07325233 chr21:34638662 IL10RB 0.37 6.0 0.31 5.24e-9 Liver disease severity in Alagille syndrome; CRC cis rs294883 0.739 rs962337 chr6:159729404 T/A cg14500486 chr6:159655392 FNDC1 -0.36 -6.19 -0.32 1.81e-9 Coronary artery disease; CRC trans rs9650657 0.506 rs7823296 chr8:10778546 A/G cg06636001 chr8:8085503 FLJ10661 -0.65 -9.6 -0.47 2.19e-19 Neuroticism; CRC cis rs8005677 0.962 rs8003934 chr14:23401142 A/G cg25600027 chr14:23388339 RBM23 -0.51 -7.86 -0.4 5.48e-14 Cognitive ability (multi-trait analysis); CRC cis rs7615952 0.599 rs2333408 chr3:125732098 G/A cg05084668 chr3:125655381 ALG1L -0.52 -8.2 -0.41 5.52e-15 Blood pressure (smoking interaction); CRC cis rs2115536 1.000 rs2115540 chr15:80190308 A/G cg00225070 chr15:80189496 MTHFS 0.52 8.18 0.41 6.17e-15 Eosinophil counts;Eosinophil percentage of white cells;Sum eosinophil basophil counts;Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; CRC cis rs11240408 1 rs11240408 chr1:205264536 A/T cg21643547 chr1:205240462 TMCC2 0.45 7.63 0.39 2.54e-13 Platelet count; CRC cis rs1129187 0.755 rs13215983 chr6:42924193 C/T cg03790207 chr6:42947109 PEX6 -0.52 -7.68 -0.39 1.82e-13 Alzheimer's disease in APOE e4+ carriers; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg20140052 chr17:79367844 NA 0.39 5.98 0.31 5.7e-9 Intelligence (multi-trait analysis); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg04349673 chr14:36278568 RALGAPA1 0.45 6.03 0.32 4.38e-9 Response to antipsychotic treatment; CRC cis rs644799 0.763 rs2950521 chr11:95536870 G/A cg25622487 chr11:95524042 FAM76B;CEP57 0.75 11.82 0.55 4.16e-27 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC trans rs7267979 0.966 rs6050567 chr20:25354561 C/T cg17903999 chr18:56338584 MALT1 0.41 6.79 0.35 5.23e-11 Liver enzyme levels (alkaline phosphatase); CRC cis rs877282 0.891 rs34652870 chr10:772218 T/C cg06581033 chr10:766294 NA -0.5 -5.76 -0.3 1.93e-8 Uric acid levels; CRC cis rs1656402 0.953 rs1190446 chr2:233420683 G/C cg03852847 chr2:233439513 NA 0.43 7.06 0.36 9.92e-12 Non-small cell lung cancer (survival); CRC cis rs1218582 0.772 rs6656435 chr1:154876869 G/A cg16680214 chr1:154839983 KCNN3 -0.45 -8.95 -0.44 2.66e-17 Prostate cancer; CRC trans rs2303319 0.504 rs72873603 chr2:162469665 C/T cg18122310 chr12:50236657 BCDIN3D -0.73 -6.17 -0.32 2.02e-9 Cognitive function; CRC cis rs875971 0.545 rs801199 chr7:66025273 A/G cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.56 -7.25 -0.37 3.06e-12 Aortic root size; CRC cis rs559928 1.000 rs72926038 chr11:64142391 G/C cg19465662 chr11:63993652 NUDT22;TRPT1 0.6 5.63 0.3 3.93e-8 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; CRC cis rs910316 1.000 rs4903275 chr14:75512509 C/T cg03030879 chr14:75389066 RPS6KL1 -0.45 -6.99 -0.36 1.57e-11 Height; CRC cis rs8078723 1.000 rs4794824 chr17:38179290 G/A cg17467752 chr17:38218738 THRA 0.75 12.16 0.56 2.32e-28 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); CRC cis rs7772486 0.754 rs6570703 chr6:145957052 C/T cg13319975 chr6:146136371 FBXO30 -0.42 -6.3 -0.33 9.47e-10 Lobe attachment (rater-scored or self-reported); CRC cis rs9925964 0.804 rs9926533 chr16:31014179 C/T cg03418659 chr16:31128414 MYST1 0.42 6.22 0.32 1.54e-9 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs365302 0.672 rs396364 chr6:159611151 C/T cg14500486 chr6:159655392 FNDC1 0.6 8.59 0.43 3.42e-16 Coronary heart disease; CRC cis rs863345 0.604 rs2317969 chr1:158491753 A/G cg12129480 chr1:158549410 OR10X1 -0.3 -6.25 -0.33 1.25e-9 Pneumococcal bacteremia; CRC cis rs754466 0.606 rs56402185 chr10:79585848 G/A cg17075019 chr10:79541650 NA -0.97 -17.97 -0.7 8.88e-51 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs8062405 0.755 rs4787457 chr16:28555400 A/G cg05139728 chr16:28306816 SBK1 -0.37 -5.98 -0.31 5.74e-9 Cognitive ability (multi-trait analysis);Cognitive ability; CRC cis rs12477438 0.798 rs4324365 chr2:99623845 T/G cg14399236 chr2:99771627 LIPT1;TSGA10 -0.74 -10.4 -0.5 4.36e-22 Chronic sinus infection; CRC cis rs6540556 0.723 rs7539852 chr1:209898539 A/G cg05527609 chr1:210001259 C1orf107 -0.5 -5.63 -0.3 3.78e-8 Red blood cell count; CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg20181420 chr10:60028918 CISD1;IPMK 0.41 6.75 0.35 6.81e-11 Obesity-related traits; CRC cis rs12142240 0.698 rs6690075 chr1:46819848 G/A cg14993813 chr1:46806288 NSUN4 -0.48 -6.15 -0.32 2.24e-9 Menopause (age at onset); CRC cis rs3736485 0.934 rs28695624 chr15:51874928 A/C cg08986416 chr15:51914746 DMXL2 -0.46 -6.56 -0.34 2.11e-10 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs853679 0.517 rs3757187 chr6:28107654 T/C cg12172441 chr6:28176163 NA 0.62 7.4 0.38 1.17e-12 Depression; CRC cis rs4972806 0.739 rs10834 chr2:177042087 A/G cg13092806 chr2:177043255 NA 0.66 9.37 0.46 1.18e-18 IgG glycosylation; CRC cis rs1707322 0.835 rs946525 chr1:46487277 A/T cg06784218 chr1:46089804 CCDC17 -0.52 -9.42 -0.46 8.2e-19 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs7193541 0.684 rs9923145 chr16:74686166 G/A cg01733217 chr16:74700730 RFWD3 1.05 21.87 0.77 4.22e-66 Multiple myeloma; CRC cis rs1577917 0.958 rs12199832 chr6:86652748 T/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.52 -6.79 -0.35 5.09e-11 Response to antipsychotic treatment; CRC cis rs796364 0.813 rs4672686 chr2:201065044 A/G cg12253985 chr2:200820533 C2orf60;C2orf47 0.5 5.69 0.3 2.81e-8 Schizophrenia; CRC cis rs11148252 0.755 rs116860555 chr13:52936937 C/T cg00495681 chr13:53174319 NA -0.58 -8.84 -0.44 5.99e-17 Lewy body disease; CRC cis rs9549328 0.670 rs35992827 chr13:113616752 G/A cg08614441 chr13:113633676 MCF2L 0.37 6.59 0.34 1.76e-10 Systolic blood pressure; CRC cis rs11997175 0.653 rs7817167 chr8:33633088 A/C ch.8.33884649F chr8:33765107 NA 0.42 6.48 0.34 3.37e-10 Body mass index; CRC cis rs12135062 0.538 rs2651929 chr1:3101353 C/T cg25382214 chr1:3105252 PRDM16 0.42 7.32 0.37 1.9e-12 Migraine; CRC cis rs9322193 0.962 rs9689242 chr6:150109106 T/C cg05861140 chr6:150128134 PCMT1 -0.43 -7.05 -0.36 1.03e-11 Lung cancer; CRC cis rs861020 0.959 rs641348 chr1:209992043 A/G cg05527609 chr1:210001259 C1orf107 1.04 13.15 0.59 5.14e-32 Orofacial clefts; CRC cis rs7833986 0.501 rs2719259 chr8:56941630 A/G cg23139584 chr8:56987506 RPS20;SNORD54 0.83 11.64 0.54 1.89e-26 Height; CRC cis rs6543140 0.964 rs6543142 chr2:103082006 T/C cg09003973 chr2:102972529 NA 0.41 5.83 0.31 1.33e-8 Blood protein levels; CRC cis rs514406 0.861 rs12141260 chr1:53300127 C/T cg08859206 chr1:53392774 SCP2 -0.42 -6.57 -0.34 1.97e-10 Monocyte count; CRC cis rs3806843 0.900 rs2531340 chr5:140131046 C/T cg16607685 chr5:140181889 PCDHA2;PCDHA1;PCDHA3 0.26 5.93 0.31 7.73e-9 Depressive symptoms (multi-trait analysis); CRC cis rs17270561 0.609 rs7772382 chr6:25708116 C/T cg16482183 chr6:26056742 HIST1H1C 0.73 9.21 0.45 3.97e-18 Iron status biomarkers; CRC cis rs1003719 0.751 rs55740803 chr21:38542761 G/A cg10648535 chr21:38446584 PIGP;TTC3 -0.48 -6.58 -0.34 1.83e-10 Eye color traits; CRC cis rs2032447 0.802 rs198853 chr6:26104096 T/C cg12310025 chr6:25882481 NA 0.46 6.38 0.33 6.1e-10 Intelligence (multi-trait analysis); CRC cis rs6076065 0.707 rs12349 chr20:23352480 A/G cg11657817 chr20:23433608 CST11 0.55 9.16 0.45 5.74e-18 Facial morphology (factor 15, philtrum width); CRC cis rs10504229 0.906 rs73607869 chr8:58172665 G/T cg01721255 chr8:58191610 C8orf71 0.49 6.17 0.32 2e-9 Developmental language disorder (linguistic errors); CRC cis rs208520 0.955 rs208532 chr6:66961280 T/A cg07460842 chr6:66804631 NA -0.92 -11.45 -0.53 8.97e-26 Exhaled nitric oxide output; CRC cis rs6163 0.727 rs284854 chr10:104574562 T/G cg11453585 chr10:104263688 ACTR1A;SUFU 0.44 6.41 0.33 5.12e-10 Waist circumference;Hip circumference; CRC cis rs7091068 0.566 rs1326220 chr10:95486155 G/A cg20715218 chr10:95462985 C10orf4 0.54 5.71 0.3 2.57e-8 Urinary tract infection frequency; CRC cis rs6461049 0.765 rs3800908 chr7:2159437 C/T cg04267008 chr7:1944627 MAD1L1 -0.46 -6.56 -0.34 2.06e-10 Schizophrenia; CRC trans rs7944735 0.517 rs12274550 chr11:48196752 C/A cg15704280 chr7:45808275 SEPT13 0.61 6.18 0.32 1.93e-9 Intraocular pressure; CRC cis rs9814567 0.806 rs4245904 chr3:134321808 G/A cg06541857 chr3:134203789 ANAPC13;CEP63 -0.37 -5.73 -0.3 2.3e-8 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs7666738 0.830 rs11722272 chr4:99000839 C/T cg17366294 chr4:99064904 C4orf37 0.44 7.34 0.38 1.7e-12 Colonoscopy-negative controls vs population controls; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg23629415 chr14:54955474 GMFB 0.54 7.22 0.37 3.55e-12 Thyroid stimulating hormone; CRC cis rs56114371 0.568 rs200468 chr6:27757855 C/G cg19041857 chr6:27730383 NA -0.48 -6.05 -0.32 3.9e-9 Breast cancer; CRC cis rs2180341 1.000 rs6569477 chr6:127589302 T/A cg27446573 chr6:127587934 RNF146 0.99 14.56 0.63 2.05e-37 Breast cancer; CRC cis rs12188164 0.965 rs11743639 chr5:450710 C/T cg17553881 chr5:443987 EXOC3;C5orf55 -0.37 -7.9 -0.4 4.09e-14 Cystic fibrosis severity; CRC cis rs12134245 1.000 rs12134245 chr1:92021464 C/T cg21854759 chr1:92012499 NA -0.49 -7.56 -0.38 3.92e-13 Breast cancer; CRC cis rs478304 0.654 rs6591185 chr11:65455742 A/G cg05805236 chr11:65401703 PCNXL3 -0.41 -6.57 -0.34 1.93e-10 Acne (severe); CRC cis rs875971 0.800 rs427557 chr7:65519250 A/G cg18876405 chr7:65276391 NA 0.51 8.8 0.44 8.15e-17 Aortic root size; CRC cis rs9291683 0.507 rs3796837 chr4:10011321 C/G cg00071950 chr4:10020882 SLC2A9 0.61 10.77 0.51 2.3e-23 Bone mineral density; CRC cis rs2294693 0.947 rs9349176 chr6:40989525 C/T cg14769373 chr6:40998127 UNC5CL -0.56 -7.46 -0.38 7.65e-13 Gastric cancer;Non-cardia gastric cancer; CRC cis rs28386778 0.897 rs2727333 chr17:61876023 G/A cg25654072 chr17:61904446 PSMC5;FTSJ3 0.72 11.24 0.53 5.2e-25 Prudent dietary pattern; CRC cis rs7932354 0.583 rs7480140 chr11:46856335 A/G cg19486271 chr11:47235900 DDB2 -0.43 -6.55 -0.34 2.25e-10 Bone mineral density (hip);Bone mineral density; CRC cis rs7725052 0.561 rs6890667 chr5:40457232 T/A cg09067459 chr5:40385259 NA -0.4 -6.15 -0.32 2.19e-9 Pediatric autoimmune diseases; CRC cis rs7927592 0.913 rs11228276 chr11:68307525 A/G cg16797656 chr11:68205561 LRP5 0.36 5.75 0.3 2.08e-8 Total body bone mineral density; CRC cis rs11628318 0.614 rs10140498 chr14:103154191 A/G cg23461800 chr14:103021989 NA 0.56 6.7 0.35 9.17e-11 Platelet count; CRC cis rs1401999 0.628 rs7639048 chr3:183746044 A/G cg05044414 chr3:183734942 ABCC5 0.43 7.52 0.38 5.38e-13 Anterior chamber depth; CRC cis rs2361718 0.500 rs4889970 chr17:78096086 C/T cg27427491 chr17:78079615 GAA 0.45 5.86 0.31 1.12e-8 Yeast infection; CRC cis rs2243480 1.000 rs35396113 chr7:65495461 C/T cg18252515 chr7:66147081 NA -1.11 -12.26 -0.56 1.04e-28 Diabetic kidney disease; CRC cis rs72945132 0.825 rs2277273 chr11:70223992 T/C cg14191688 chr11:70257035 CTTN 0.4 5.66 0.3 3.29e-8 Coronary artery disease; CRC cis rs7725052 0.609 rs10941508 chr5:40459067 A/G cg09067459 chr5:40385259 NA -0.4 -6.68 -0.35 9.91e-11 Pediatric autoimmune diseases; CRC cis rs60871478 0.947 rs62432255 chr7:804219 G/A cg04727924 chr7:799746 HEATR2 -0.45 -6.77 -0.35 6e-11 Cerebrospinal P-tau181p levels; CRC trans rs7142881 0.508 rs4981871 chr14:32118636 T/C cg10453823 chr2:190539512 ANKAR -0.4 -5.99 -0.31 5.65e-9 Response to iloperidone treatment (QT prolongation); CRC cis rs9463078 0.546 rs6458418 chr6:45014997 G/A cg25276700 chr6:44698697 NA 0.24 5.65 0.3 3.54e-8 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; CRC cis rs1862618 0.802 rs986049 chr5:56110233 G/A cg12311346 chr5:56204834 C5orf35 -0.8 -10.65 -0.51 6.01e-23 Initial pursuit acceleration; CRC cis rs8105895 0.935 rs62111030 chr19:22279375 C/A cg02912127 chr19:22235281 ZNF257 -0.41 -5.71 -0.3 2.54e-8 Body mass index (change over time); CRC cis rs916888 0.821 rs70602 chr17:44859715 T/C cg15921436 chr17:44337874 NA -0.68 -7.81 -0.4 7.78e-14 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs447 0.806 rs929334 chr7:83744373 T/C cg22846510 chr7:83753280 SEMA3A -0.42 -5.76 -0.3 1.95e-8 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs35520189 0.591 rs6722962 chr2:113701383 T/G cg12858261 chr2:113808755 IL1F8 0.49 6.87 0.35 3.29e-11 Obstructive sleep apnea trait (apnea hypopnea index); CRC cis rs2635047 0.542 rs2684853 chr18:44793532 G/A cg19077165 chr18:44547161 KATNAL2 -0.38 -5.84 -0.31 1.28e-8 Educational attainment; CRC cis rs897984 0.770 rs12930657 chr16:30931968 C/T cg00531865 chr16:30841666 NA 0.49 7.0 0.36 1.48e-11 Dementia with Lewy bodies; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg01593421 chr7:65303149 NA -0.41 -6.71 -0.35 8.6e-11 Liver disease severity in Alagille syndrome; CRC cis rs10242455 0.702 rs28668326 chr7:98998153 G/A cg18809830 chr7:99032528 PTCD1 -1.12 -8.16 -0.41 7.01e-15 Blood metabolite levels; CRC cis rs796364 0.806 rs78527234 chr2:200913453 C/T cg25936922 chr2:200820526 C2orf60;C2orf47 -0.7 -6.57 -0.34 2.02e-10 Schizophrenia; CRC cis rs12368653 0.693 rs2640610 chr12:58037435 T/A cg00677455 chr12:58241039 CTDSP2 -0.47 -6.79 -0.35 5.12e-11 Multiple sclerosis; CRC cis rs1005277 0.602 rs2504142 chr10:38383793 C/T cg17219203 chr10:38645113 HSD17B7P2 -0.41 -5.76 -0.3 1.89e-8 Extrinsic epigenetic age acceleration; CRC cis rs6546324 0.625 rs6717863 chr2:67844799 C/A cg15745817 chr2:67799979 NA -0.57 -9.7 -0.47 1.01e-19 Endometriosis; CRC cis rs4713118 0.662 rs156744 chr6:27967274 G/A cg12172441 chr6:28176163 NA 0.56 7.57 0.39 3.8e-13 Parkinson's disease; CRC cis rs7584330 0.554 rs74832280 chr2:238426625 G/A cg08992911 chr2:238395768 MLPH 0.47 5.76 0.3 1.89e-8 Prostate cancer; CRC cis rs11640734 0.609 rs11647746 chr16:89806343 C/A cg06558623 chr16:89946397 TCF25 0.94 9.69 0.47 1.09e-19 Interleukin-17 levels; CRC cis rs13256369 0.802 rs12681326 chr8:8566389 G/A cg18904891 chr8:8559673 CLDN23 0.53 7.04 0.36 1.1e-11 Obesity-related traits; CRC cis rs601339 0.938 rs1696345 chr12:123183060 T/G cg25190513 chr12:123201362 GPR109B -0.5 -6.25 -0.33 1.31e-9 Adiponectin levels; CRC cis rs7523050 0.643 rs7519293 chr1:109399543 A/G cg08274380 chr1:109419600 GPSM2 0.84 6.6 0.34 1.69e-10 Fat distribution (HIV); CRC cis rs10028773 0.666 rs12498657 chr4:120262866 G/C cg09307838 chr4:120376055 NA 0.62 9.62 0.47 1.82e-19 Educational attainment; CRC cis rs932287 0.545 rs1960181 chr11:9046767 A/C cg00186954 chr11:8933980 ST5;C11orf17 0.6 9.69 0.47 1.06e-19 Colonoscopy-negative controls vs population controls; CRC cis rs1552244 1.000 rs28684871 chr3:10072635 C/A cg08888203 chr3:10149979 C3orf24 0.67 9.19 0.45 4.67e-18 Alzheimer's disease; CRC cis rs9291683 0.595 rs13145442 chr4:10037261 C/A cg00071950 chr4:10020882 SLC2A9 0.67 12.66 0.57 3.54e-30 Bone mineral density; CRC cis rs4862750 0.794 rs7692427 chr4:187901727 G/A cg03452623 chr4:187889614 NA -0.92 -22.45 -0.78 2.37e-68 Lobe attachment (rater-scored or self-reported); CRC cis rs1865760 0.713 rs9461229 chr6:25992279 G/T cg18357526 chr6:26021779 HIST1H4A 0.41 5.99 0.31 5.36e-9 Height; CRC cis rs4972806 0.814 rs6710370 chr2:177045969 T/C cg03152288 chr2:177042942 NA 0.81 13.08 0.59 8.83e-32 IgG glycosylation; CRC cis rs2032447 0.714 rs2051540 chr6:25947197 T/C cg03517284 chr6:25882590 NA -0.59 -8.23 -0.41 4.36e-15 Intelligence (multi-trait analysis); CRC cis rs7843479 0.601 rs11781959 chr8:21841863 C/G cg17168535 chr8:21777572 XPO7 0.62 10.58 0.5 1.05e-22 Mean corpuscular volume; CRC cis rs4332037 0.539 rs1533827 chr7:2074290 A/G cg02825527 chr7:2087843 MAD1L1 0.45 5.61 0.3 4.31e-8 Bipolar disorder; CRC cis rs7605827 0.930 rs4668909 chr2:15607842 T/C cg19274914 chr2:15703543 NA 0.38 5.8 0.3 1.57e-8 Educational attainment (years of education); CRC cis rs7937682 0.883 rs566647 chr11:111466607 A/G cg19812747 chr11:111475976 SIK2 0.55 8.98 0.44 2.08e-17 Primary sclerosing cholangitis; CRC trans rs7615952 0.546 rs2979307 chr3:125309574 C/T cg16558177 chr4:4109446 NA 0.52 6.33 0.33 7.86e-10 Blood pressure (smoking interaction); CRC cis rs11702148 0.552 rs2154583 chr21:34888940 T/G cg14850771 chr21:34775459 IFNGR2 0.39 5.74 0.3 2.14e-8 Mean corpuscular hemoglobin; CRC trans rs2470578 0.716 rs2733514 chr3:17323931 A/G cg27134732 chr2:85108175 C2orf89 -0.46 -6.63 -0.34 1.39e-10 Schizophrenia; CRC cis rs6076065 0.723 rs6137908 chr20:23344590 G/A cg11657817 chr20:23433608 CST11 0.43 6.25 0.33 1.31e-9 Facial morphology (factor 15, philtrum width); CRC trans rs2727020 0.513 rs10839307 chr11:49609843 A/C cg15704280 chr7:45808275 SEPT13 -0.94 -17.93 -0.7 1.29e-50 Coronary artery disease; CRC cis rs56399783 0.901 rs7803944 chr7:2809087 G/A cg19731401 chr7:2775893 GNA12 0.58 6.54 0.34 2.29e-10 Childhood ear infection; CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg02668984 chr17:48172022 PDK2 -0.54 -6.64 -0.34 1.29e-10 Diisocyanate-induced asthma; CRC cis rs10991814 1.000 rs78826784 chr9:93944200 G/A cg14446406 chr9:93919335 NA 0.61 6.97 0.36 1.74e-11 Neutrophil percentage of granulocytes; CRC cis rs12148488 0.966 rs1867149 chr15:75339993 C/T cg17294928 chr15:75287854 SCAMP5 -0.42 -6.07 -0.32 3.48e-9 Caffeine consumption; CRC cis rs10883723 0.847 rs3808934 chr10:104264280 C/T cg04362960 chr10:104952993 NT5C2 -0.43 -6.1 -0.32 2.92e-9 Allergic disease (asthma, hay fever or eczema); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg26371787 chr6:7910221 TXNDC5 0.4 6.26 0.33 1.17e-9 Liver disease severity in Alagille syndrome; CRC cis rs2980439 0.846 rs2980437 chr8:8094763 C/T cg06636001 chr8:8085503 FLJ10661 -0.73 -12.36 -0.56 4.52e-29 Neuroticism; CRC cis rs4862750 0.872 rs6830426 chr4:187897270 T/A cg03452623 chr4:187889614 NA -0.93 -22.01 -0.77 1.17e-66 Lobe attachment (rater-scored or self-reported); CRC trans rs11088226 0.681 rs2833891 chr21:33928821 A/G cg09050820 chr6:167586206 TCP10L2 0.85 9.35 0.46 1.44e-18 Gastritis; CRC cis rs2160860 0.965 rs7013824 chr8:39808425 A/G cg11363097 chr8:39792086 IDO2 -0.4 -6.66 -0.34 1.14e-10 Blood metabolite levels; CRC cis rs1448094 0.842 rs7309725 chr12:86440612 T/C cg02569458 chr12:86230093 RASSF9 0.4 6.77 0.35 6.08e-11 Major depressive disorder; CRC cis rs13191362 0.507 rs2849518 chr6:163134248 T/C cg21926612 chr6:163149169 PACRG;PARK2 -0.63 -9.92 -0.48 1.84e-20 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs2841277 0.616 rs1048257 chr14:105404384 T/C cg15352829 chr14:105391018 PLD4 -0.5 -10.86 -0.51 1.13e-23 Rheumatoid arthritis; CRC cis rs1552244 1.000 rs3846177 chr3:10068572 G/T cg13047869 chr3:10149882 C3orf24 0.51 7.07 0.36 9.31e-12 Alzheimer's disease; CRC cis rs7172809 0.643 rs75159723 chr15:77841841 A/G cg10437265 chr15:77819839 NA -0.35 -5.86 -0.31 1.13e-8 Glucose homeostasis traits; CRC trans rs116095464 0.558 rs1541822 chr5:269234 A/C cg00938859 chr5:1591904 SDHAP3 -0.75 -8.06 -0.41 1.41e-14 Breast cancer; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg21792150 chr3:101567884 NFKBIZ 0.39 6.05 0.32 3.91e-9 Liver disease severity in Alagille syndrome; CRC cis rs10504229 0.728 rs17216187 chr8:58158778 G/T cg08219700 chr8:58056026 NA 0.46 5.72 0.3 2.37e-8 Developmental language disorder (linguistic errors); CRC cis rs853679 0.542 rs9393892 chr6:28081394 A/G cg25164649 chr6:28176230 NA 0.75 9.35 0.46 1.35e-18 Depression; CRC cis rs9611519 0.542 rs8139770 chr22:41416181 C/T cg03806693 chr22:41940476 POLR3H -0.4 -5.69 -0.3 2.84e-8 Neuroticism; CRC cis rs1670533 0.929 rs6599280 chr4:1063818 A/G cg27284194 chr4:1044797 NA 0.48 5.93 0.31 7.8e-9 Recombination rate (females); CRC cis rs9488822 0.702 rs10872141 chr6:116323246 C/A cg18764771 chr6:116381957 FRK 0.25 7.02 0.36 1.28e-11 Cholesterol, total;LDL cholesterol; CRC cis rs698833 0.926 rs1067370 chr2:44652343 T/G cg04920474 chr2:44395004 PPM1B 0.42 6.11 0.32 2.79e-9 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; CRC cis rs73206853 0.698 rs871922 chr12:111114942 T/C cg12870014 chr12:110450643 ANKRD13A 0.86 9.64 0.47 1.53e-19 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC cis rs911119 1.000 rs35488434 chr20:23620401 T/C cg16589663 chr20:23618590 CST3 0.62 8.01 0.4 2.01e-14 Chronic kidney disease; CRC cis rs10744422 1.000 rs10847869 chr12:123328359 C/G cg25930673 chr12:123319894 HIP1R -0.54 -5.87 -0.31 1.04e-8 Schizophrenia; CRC cis rs1862618 0.671 rs2591968 chr5:56233541 A/G cg22800045 chr5:56110881 MAP3K1 0.47 5.85 0.31 1.21e-8 Initial pursuit acceleration; CRC cis rs2303745 0.589 rs11882562 chr19:17395055 C/G cg27101125 chr19:17392770 ANKLE1 0.32 5.74 0.3 2.13e-8 Systemic lupus erythematosus; CRC cis rs9896933 0.732 rs590886 chr17:80767350 A/G cg02186141 chr17:80864562 TBCD -0.38 -5.65 -0.3 3.45e-8 Bone mineral accretion in asthma (oral corticosteroid dose interaction); CRC cis rs9910055 0.659 rs7212573 chr17:42254281 A/G cg19774624 chr17:42201019 HDAC5 -0.73 -11.63 -0.54 1.94e-26 Total body bone mineral density; CRC cis rs7945718 0.839 rs11022512 chr11:12835952 G/A cg25843174 chr11:12811716 TEAD1 0.5 9.42 0.46 8.46e-19 Educational attainment (years of education); CRC cis rs4862750 0.874 rs6822062 chr4:187895553 T/C cg27532560 chr4:187881888 NA -0.56 -10.28 -0.49 1.1e-21 Lobe attachment (rater-scored or self-reported); CRC cis rs1862618 0.756 rs13356762 chr5:56110992 G/T cg22800045 chr5:56110881 MAP3K1 0.55 5.96 0.31 6.48e-9 Initial pursuit acceleration; CRC cis rs514406 0.861 rs6588443 chr1:53250650 G/A cg24675658 chr1:53192096 ZYG11B 0.56 8.18 0.41 6.21e-15 Monocyte count; CRC cis rs9287719 0.649 rs10175884 chr2:10718534 C/T cg00105475 chr2:10696890 NA 0.45 7.06 0.36 9.97e-12 Prostate cancer; CRC cis rs3617 0.573 rs3821873 chr3:52913006 C/T cg15147215 chr3:52552868 STAB1 0.42 7.03 0.36 1.17e-11 Red blood cell count;Autism spectrum disorder or schizophrenia; CRC cis rs10791097 0.739 rs12279359 chr11:130730544 G/A cg12179176 chr11:130786555 SNX19 0.68 11.08 0.52 1.79e-24 Autism spectrum disorder or schizophrenia;Schizophrenia; CRC trans rs35110281 0.667 rs2838354 chr21:45119857 T/C cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.44 6.94 0.36 2.11e-11 Mean corpuscular volume; CRC cis rs79349575 0.756 rs3848460 chr17:47047114 A/G cg22482690 chr17:47019901 SNF8 -0.5 -8.23 -0.41 4.56e-15 Type 2 diabetes; CRC cis rs9467603 0.800 rs4236040 chr6:25761209 T/C cg08501292 chr6:25962987 TRIM38 -0.93 -8.38 -0.42 1.56e-15 Intelligence (multi-trait analysis); CRC trans rs2303319 0.504 rs56100249 chr2:162415157 T/C cg11875773 chr22:50468633 TTLL8 -0.69 -6.05 -0.32 3.84e-9 Cognitive function; CRC cis rs10504229 1.000 rs17805549 chr8:58179653 T/C cg02290350 chr8:58132656 NA -0.42 -5.96 -0.31 6.62e-9 Developmental language disorder (linguistic errors); CRC cis rs7568458 1.000 rs7568458 chr2:85788175 T/A cg02493740 chr2:85810744 VAMP5 -0.36 -5.64 -0.3 3.62e-8 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); CRC cis rs9916302 0.752 rs9901219 chr17:37558369 T/G cg07936489 chr17:37558343 FBXL20 0.97 14.66 0.63 8.09e-38 Glomerular filtration rate (creatinine); CRC cis rs2075371 1.000 rs2075371 chr7:133984127 A/G cg11752832 chr7:134001865 SLC35B4 0.5 7.75 0.39 1.13e-13 Mean platelet volume; CRC cis rs7762018 0.770 rs3823466 chr6:170189926 C/T cg19338460 chr6:170058176 WDR27 -0.62 -7.11 -0.36 7.44e-12 Thiazide-induced adverse metabolic effects in hypertensive patients; CRC cis rs10504229 0.683 rs79262965 chr8:58129826 G/T cg24829409 chr8:58192753 C8orf71 -0.62 -7.92 -0.4 3.68e-14 Developmental language disorder (linguistic errors); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg22807378 chr6:170151601 TCTE3;C6orf70 0.38 6.28 0.33 1.09e-9 Liver disease severity in Alagille syndrome; CRC cis rs13064411 0.696 rs869343 chr3:113226705 C/T cg18753928 chr3:113234510 CCDC52 -0.7 -10.74 -0.51 2.89e-23 Response to simvastatin treatment (PCSK9 protein level change); CRC cis rs826838 0.510 rs17523988 chr12:39222785 A/C cg26384229 chr12:38710491 ALG10B 0.56 6.78 0.35 5.54e-11 Heart rate; CRC cis rs896854 0.625 rs4735335 chr8:95973327 G/C cg13393036 chr8:95962371 TP53INP1 -0.54 -9.27 -0.46 2.49e-18 Type 2 diabetes; CRC cis rs4665809 0.590 rs13016300 chr2:26468365 G/C cg25036284 chr2:26402008 FAM59B 0.61 7.76 0.39 1.09e-13 Gut microbiome composition (summer); CRC cis rs40363 0.645 rs4786421 chr16:3522303 A/G cg05754148 chr16:3507555 NAT15 -0.47 -6.73 -0.35 7.56e-11 Tuberculosis; CRC cis rs1550582 1.000 rs7822348 chr8:135542483 C/G cg17885191 chr8:135476712 NA 0.73 8.97 0.44 2.23e-17 Educational attainment; CRC cis rs394563 0.625 rs384306 chr6:149796140 A/G cg11245181 chr6:149772854 ZC3H12D -0.43 -6.74 -0.35 7.2e-11 Dupuytren's disease; CRC trans rs3794271 0.706 rs9971816 chr12:20826911 C/T cg25667490 chr4:72052924 SLC4A4 0.38 6.04 0.32 4.22e-9 Response to TNF-alpha inhibitors in rheumatoid arthritis; CRC trans rs6952808 0.717 rs12534679 chr7:1926745 G/A cg04565464 chr8:145669602 NFKBIL2 0.39 6.06 0.32 3.83e-9 Bipolar disorder and schizophrenia; CRC cis rs61008539 0.815 rs6960062 chr7:884665 A/G cg07138768 chr7:917805 C7orf20 0.3 5.69 0.3 2.83e-8 Perceived unattractiveness to mosquitoes; CRC cis rs6665290 0.904 rs11578103 chr1:227189642 C/A cg10327440 chr1:227177885 CDC42BPA -1.04 -23.06 -0.79 1.07e-70 Myeloid white cell count; CRC cis rs172166 0.694 rs1631552 chr6:28089699 C/A cg25164649 chr6:28176230 NA 0.62 8.92 0.44 3.31e-17 Cardiac Troponin-T levels; CRC cis rs2292096 0.929 rs6667419 chr1:200756197 G/C cg07580975 chr1:200843333 NA 0.43 5.92 0.31 8.27e-9 Epilepsy; CRC cis rs757110 0.866 rs5213 chr11:17408404 C/T cg15432903 chr11:17409602 KCNJ11 0.8 12.26 0.56 1e-28 Type 2 diabetes; CRC cis rs4654899 0.897 rs10916859 chr1:21087956 A/G cg02927042 chr1:21476669 EIF4G3 -0.44 -6.87 -0.35 3.29e-11 Superior frontal gyrus grey matter volume; CRC cis rs3126085 0.877 rs4456098 chr1:152176034 C/T cg09127314 chr1:152161683 NA 0.52 6.57 0.34 1.95e-10 Atopic dermatitis; CRC cis rs7659604 0.539 rs7686084 chr4:122764725 A/C cg20573242 chr4:122745356 CCNA2 0.57 8.57 0.43 4.01e-16 Type 2 diabetes; CRC cis rs9303401 0.659 rs7223708 chr17:56896398 A/G cg10487724 chr17:56770010 TEX14;RAD51C 0.76 9.59 0.47 2.2e-19 Cognitive test performance; CRC cis rs9733 0.519 rs10788792 chr1:150638572 T/G cg17724175 chr1:150552817 MCL1 0.59 9.61 0.47 2.03e-19 Tonsillectomy; CRC trans rs1814175 0.616 rs1722001 chr11:49894427 A/G cg03929089 chr4:120376271 NA -0.91 -16.08 -0.66 2.35e-43 Height; CRC cis rs11212617 1.000 rs608086 chr11:108185023 G/A cg14761454 chr11:108092087 ATM;NPAT 0.43 6.5 0.34 2.91e-10 Response to metformin in type 2 diabetes (glycemic); CRC cis rs7666738 0.830 rs4699584 chr4:98952019 A/G cg05340658 chr4:99064831 C4orf37 0.61 9.54 0.47 3.45e-19 Colonoscopy-negative controls vs population controls; CRC cis rs4819852 0.958 rs2238787 chr22:19976406 G/A cg07821417 chr22:19972146 ARVCF 0.45 6.06 0.32 3.63e-9 Pulse pressure; CRC cis rs9796 0.621 rs2928142 chr15:41470449 T/C cg18705301 chr15:41695430 NDUFAF1 0.42 6.88 0.35 3.03e-11 Menopause (age at onset); CRC cis rs889398 0.742 rs12446197 chr16:69854869 A/G cg00738113 chr16:70207722 CLEC18C 0.36 6.2 0.32 1.69e-9 Body mass index; CRC cis rs12908161 1.000 rs17600551 chr15:85319258 A/G cg11189052 chr15:85197271 WDR73 0.59 8.58 0.43 3.73e-16 Schizophrenia; CRC cis rs4713118 0.786 rs200502 chr6:27788062 C/T cg12172441 chr6:28176163 NA 0.51 6.24 0.33 1.34e-9 Parkinson's disease; CRC cis rs4888262 0.526 rs4887776 chr16:74635632 A/G cg01733217 chr16:74700730 RFWD3 0.79 12.06 0.55 5.49e-28 Testicular germ cell tumor; CRC trans rs2228479 0.850 rs1800344 chr16:89816367 T/G cg24644049 chr4:85504048 CDS1 0.9 7.46 0.38 7.69e-13 Skin colour saturation; CRC cis rs1023500 0.505 rs134901 chr22:42683520 C/T cg15557168 chr22:42548783 NA -0.36 -6.19 -0.32 1.76e-9 Schizophrenia; CRC cis rs8008758 1.000 rs915379 chr14:101689392 T/C cg26224664 chr14:101693935 NA -0.4 -6.09 -0.32 3.21e-9 Body mass index (alcohol intake interaction); CRC cis rs3796352 1.000 rs2336541 chr3:52974630 G/C cg27565382 chr3:53032988 SFMBT1 0.7 6.16 0.32 2.07e-9 Immune reponse to smallpox (secreted IL-2); CRC cis rs62408225 0.962 rs58521088 chr6:90985198 A/T cg06866423 chr6:90926672 BACH2 0.48 7.9 0.4 4.14e-14 Eosinophil counts;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC cis rs2415984 0.622 rs12435397 chr14:46940867 G/A cg14871534 chr14:47121158 RPL10L -0.44 -6.23 -0.32 1.43e-9 Number of children ever born; CRC cis rs950169 0.526 rs698620 chr15:85177208 G/A cg09876464 chr15:85330779 ZNF592 0.39 6.5 0.34 2.99e-10 Schizophrenia; CRC cis rs1448094 0.512 rs4540904 chr12:86235472 A/G cg25456477 chr12:86230367 RASSF9 0.33 5.69 0.3 2.77e-8 Major depressive disorder; CRC cis rs9911578 0.803 rs8069033 chr17:57131581 T/A cg05425664 chr17:57184151 TRIM37 0.52 8.17 0.41 6.53e-15 Intelligence (multi-trait analysis); CRC cis rs3858526 0.514 rs4595572 chr11:5864045 T/G cg26762873 chr11:5879799 OR52E8 -0.49 -8.32 -0.42 2.36e-15 DNA methylation (variation); CRC cis rs10089 1.000 rs2409109 chr5:127461471 C/T cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.72 9.97 0.48 1.28e-20 Ileal carcinoids; CRC cis rs1003719 0.715 rs2835642 chr21:38539066 A/G cg10648535 chr21:38446584 PIGP;TTC3 -0.48 -6.72 -0.35 7.91e-11 Eye color traits; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg04631757 chr12:58176492 TSFM 0.42 6.02 0.31 4.63e-9 Intelligence (multi-trait analysis); CRC cis rs3733585 0.673 rs6850143 chr4:9958924 T/C cg00071950 chr4:10020882 SLC2A9 -0.54 -9.65 -0.47 1.42e-19 Cleft plate (environmental tobacco smoke interaction); CRC cis rs9468186 1 rs9468186 chr6:27626631 A/G cg03623178 chr6:28175578 NA 0.5 6.06 0.32 3.78e-9 Neuroticism; CRC cis rs12410462 0.579 rs78343168 chr1:227621090 G/A cg23173402 chr1:227635558 NA 0.88 9.01 0.44 1.68e-17 Major depressive disorder; CRC cis rs10746514 0.813 rs9724918 chr1:232248087 C/T cg09506761 chr1:232265262 NA 0.42 5.9 0.31 9.22e-9 Response to statin therapy; CRC cis rs11098499 0.954 rs2389803 chr4:120393511 A/G cg24375607 chr4:120327624 NA -0.54 -8.31 -0.42 2.52e-15 Corneal astigmatism; CRC cis rs6860806 0.661 rs4705929 chr5:131584178 G/T cg18301423 chr5:131593218 PDLIM4 0.37 6.94 0.36 2.12e-11 Breast cancer; CRC cis rs35110281 0.782 rs9981291 chr21:45031458 A/G cg01579765 chr21:45077557 HSF2BP -0.38 -7.31 -0.37 2.04e-12 Mean corpuscular volume; CRC cis rs9916302 0.904 rs4795384 chr17:37716771 C/G cg20243544 chr17:37824526 PNMT 0.41 5.71 0.3 2.54e-8 Glomerular filtration rate (creatinine); CRC cis rs10924970 0.935 rs4659674 chr1:235392354 T/A cg26050004 chr1:235667680 B3GALNT2 0.39 5.78 0.3 1.71e-8 Asthma; CRC cis rs7107770 1.000 rs61911056 chr11:125088380 A/T cg27629782 chr11:125073726 PKNOX2 0.49 5.88 0.31 1.03e-8 Photic sneeze reflex; CRC cis rs853679 1.000 rs853685 chr6:28288785 C/T cg03623178 chr6:28175578 NA 0.68 7.08 0.36 8.59e-12 Depression; CRC cis rs11212617 1.000 rs650173 chr11:108174173 G/A cg12106634 chr11:108092400 ATM;NPAT 0.41 6.14 0.32 2.33e-9 Response to metformin in type 2 diabetes (glycemic); CRC cis rs9463078 0.774 rs6458441 chr6:45327401 G/T cg25276700 chr6:44698697 NA 0.29 6.83 0.35 4.06e-11 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; CRC cis rs959260 1.000 rs2053158 chr17:73393459 A/T cg20590849 chr17:73267439 MIF4GD 0.44 5.83 0.31 1.3e-8 Systemic lupus erythematosus; CRC cis rs3772130 0.540 rs11717089 chr3:121563271 C/T cg20356878 chr3:121714668 ILDR1 0.37 6.08 0.32 3.24e-9 Cognitive performance; CRC cis rs10256972 0.641 rs12702017 chr7:1129413 C/T cg18765753 chr7:1198926 ZFAND2A -0.38 -6.45 -0.34 4.01e-10 Longevity;Endometriosis; CRC cis rs7666738 0.830 rs11731478 chr4:99001686 A/G cg05340658 chr4:99064831 C4orf37 0.61 9.54 0.47 3.44e-19 Colonoscopy-negative controls vs population controls; CRC cis rs7538876 0.903 rs730153 chr1:17749504 A/G cg01904812 chr1:17746340 RCC2 -0.35 -5.8 -0.3 1.54e-8 Basal cell carcinoma; CRC cis rs1707322 1.000 rs1707337 chr1:46508769 A/G cg03146154 chr1:46216737 IPP -0.53 -7.37 -0.38 1.42e-12 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs208520 0.526 rs9354366 chr6:66788559 C/T cg07460842 chr6:66804631 NA -1.16 -24.69 -0.81 7.19e-77 Exhaled nitric oxide output; CRC cis rs9341808 0.667 rs583426 chr6:80946687 G/A cg08355045 chr6:80787529 NA -0.36 -6.07 -0.32 3.59e-9 Sitting height ratio; CRC cis rs847577 0.506 rs7808528 chr7:97721425 G/T cg00277769 chr7:97922759 BAIAP2L1 -0.41 -6.85 -0.35 3.69e-11 Breast cancer; CRC cis rs3806843 0.801 rs2531358 chr5:140117437 A/G cg26395211 chr5:140044315 WDR55 0.38 5.68 0.3 3.04e-8 Depressive symptoms (multi-trait analysis); CRC cis rs7772486 0.790 rs9386141 chr6:146268623 T/A cg13319975 chr6:146136371 FBXO30 0.39 5.93 0.31 7.81e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs10504229 0.639 rs16921812 chr8:58106737 C/T cg02725872 chr8:58115012 NA -0.66 -11.36 -0.53 1.85e-25 Developmental language disorder (linguistic errors); CRC cis rs10504229 0.639 rs67996345 chr8:58117127 A/G cg05313129 chr8:58192883 C8orf71 -0.43 -6.11 -0.32 2.74e-9 Developmental language disorder (linguistic errors); CRC cis rs1153858 1.000 rs7167900 chr15:45639471 A/G cg14582100 chr15:45693742 SPATA5L1 0.28 5.91 0.31 8.48e-9 Homoarginine levels; CRC cis rs12983728 0.831 rs79222418 chr19:58664418 T/C cg21294424 chr19:58662284 ZNF329 0.83 9.33 0.46 1.62e-18 Cholesterol, total; CRC cis rs7618915 0.547 rs2336542 chr3:52710636 A/G cg15147215 chr3:52552868 STAB1 -0.63 -10.4 -0.5 4.44e-22 Bipolar disorder; CRC cis rs1158570 0.521 rs10089819 chr8:131172968 C/T cg26053073 chr8:131455383 NA -0.42 -6.45 -0.33 4.04e-10 Platelet count; CRC cis rs875971 0.929 rs12673810 chr7:65923853 T/A cg00343986 chr7:65444356 GUSB 0.43 6.29 0.33 1.03e-9 Aortic root size; CRC cis rs769267 0.965 rs2315024 chr19:19423817 T/A cg01262667 chr19:19385393 TM6SF2 0.38 6.3 0.33 9.76e-10 Tonsillectomy; CRC cis rs2228479 0.850 rs2239358 chr16:89827330 C/G cg06656553 chr16:89960601 TCF25 -0.7 -5.76 -0.3 1.93e-8 Skin colour saturation; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg11003009 chr5:74632112 HMGCR 0.44 6.54 0.34 2.33e-10 Thyroid stimulating hormone; CRC cis rs12410462 0.681 rs76705164 chr1:227615570 G/A cg04117972 chr1:227635322 NA 0.73 7.8 0.4 8.27e-14 Major depressive disorder; CRC cis rs25422 0.878 rs55894300 chr6:118982076 T/A cg01339444 chr6:118972232 C6orf204 0.57 6.07 0.32 3.53e-9 Renal cell carcinoma; CRC cis rs2303759 0.918 rs9749416 chr19:49885005 G/A cg24324837 chr19:49891574 CCDC155 0.56 8.17 0.41 6.92e-15 Multiple sclerosis; CRC cis rs12024301 0.557 rs7542304 chr1:183595180 A/C cg11505048 chr1:183622726 RGL1;APOBEC4 0.76 6.93 0.36 2.16e-11 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs7085104 0.591 rs4919683 chr10:104585125 G/T cg04362960 chr10:104952993 NT5C2 0.58 8.19 0.41 5.73e-15 Immature fraction of reticulocytes;Schizophrenia; CRC trans rs10411161 0.702 rs17835311 chr19:52386781 A/C cg22319618 chr22:45562946 NUP50 -0.64 -6.64 -0.34 1.28e-10 Breast cancer; CRC cis rs2839186 0.967 rs2839191 chr21:47695395 C/G cg11766577 chr21:47581405 C21orf56 -0.38 -5.81 -0.31 1.44e-8 Testicular germ cell tumor; CRC cis rs116095464 0.558 rs7703803 chr5:292311 A/G cg22857025 chr5:266934 NA -1.24 -16.22 -0.67 6.66e-44 Breast cancer; CRC cis rs9467711 0.659 rs34246779 chr6:26549212 G/A cg16898833 chr6:26189333 HIST1H4D 1.14 8.46 0.42 8.89e-16 Autism spectrum disorder or schizophrenia; CRC cis rs875971 0.545 rs73142245 chr7:65691649 A/G cg05627663 chr7:65219948 SNORA22;CCT6P1 0.63 8.19 0.41 5.86e-15 Aortic root size; CRC cis rs67340775 0.541 rs169287 chr6:27854760 C/A cg25164649 chr6:28176230 NA 0.56 5.71 0.3 2.54e-8 Lung cancer in ever smokers; CRC trans rs9929218 0.817 rs3114402 chr16:68719607 C/T cg04657470 chr2:198365150 HSPE1;HSPD1 -1.07 -16.8 -0.68 3.48e-46 Colorectal cancer; CRC cis rs478304 0.654 rs6591187 chr11:65460086 C/G cg05805236 chr11:65401703 PCNXL3 -0.41 -6.61 -0.34 1.59e-10 Acne (severe); CRC cis rs9435341 0.965 rs1730864 chr1:107607810 C/T cg14671364 chr1:107599128 PRMT6 -0.61 -8.29 -0.42 3e-15 Facial morphology (factor 21, depth of nasal alae); CRC cis rs6918586 0.658 rs198809 chr6:26128766 G/A cg18357526 chr6:26021779 HIST1H4A -0.5 -7.44 -0.38 8.66e-13 Schizophrenia; CRC cis rs2228479 0.850 rs12599473 chr16:89827435 A/C cg06656553 chr16:89960601 TCF25 -0.7 -5.76 -0.3 1.93e-8 Skin colour saturation; CRC cis rs2386661 0.543 rs61832673 chr10:5643818 C/T cg26603656 chr10:5671107 NA 0.37 6.61 0.34 1.55e-10 Breast cancer; CRC cis rs7584330 0.554 rs6729415 chr2:238429943 C/G cg14458575 chr2:238380390 NA 0.41 6.02 0.32 4.64e-9 Prostate cancer; CRC trans rs4942242 0.663 rs17460812 chr13:44215504 A/G cg26741380 chr15:41871084 TYRO3 -0.47 -6.93 -0.36 2.27e-11 Response to tocilizumab in rheumatoid arthritis; CRC cis rs763014 1.000 rs7205409 chr16:642610 A/G cg04562611 chr16:615315 C16orf11 0.35 5.93 0.31 7.66e-9 Height; CRC cis rs78456975 1.000 rs72776251 chr2:1525097 G/A cg26248373 chr2:1572462 NA -0.63 -6.54 -0.34 2.3e-10 Placebo response in major depressive disorder (% change in symptom score); CRC cis rs514406 0.679 rs11206006 chr1:53218380 A/G cg25767906 chr1:53392781 SCP2 0.52 8.04 0.41 1.61e-14 Monocyte count; CRC cis rs1843834 0.539 rs3912999 chr2:225390089 C/T cg22509189 chr2:225307070 NA -0.38 -5.89 -0.31 9.53e-9 IgE levels in asthmatics (D.p. specific); CRC cis rs9467773 1.000 rs1884948 chr6:26567988 G/A cg09904177 chr6:26538194 HMGN4 0.86 14.82 0.63 2.06e-38 Intelligence (multi-trait analysis); CRC cis rs427394 0.659 rs419128 chr5:6739791 G/A cg15145174 chr5:6755386 POLS -0.44 -6.49 -0.34 3.22e-10 Menopause (age at onset); CRC cis rs1707322 0.964 rs796773 chr1:46564475 C/T cg03146154 chr1:46216737 IPP -0.52 -7.18 -0.37 4.54e-12 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs651907 0.557 rs2303474 chr3:101371899 G/T cg11279151 chr3:101281821 RG9MTD1 -0.56 -7.5 -0.38 6.16e-13 Colorectal cancer; CRC cis rs9311474 0.507 rs4687644 chr3:52746541 T/G cg15147215 chr3:52552868 STAB1 -0.63 -10.57 -0.5 1.14e-22 Electroencephalogram traits; CRC cis rs9649213 0.593 rs2158553 chr7:97951131 G/A cg08684580 chr7:98029266 BAIAP2L1 -0.31 -5.62 -0.3 4.03e-8 Prostate cancer (SNP x SNP interaction); CRC cis rs1891275 0.515 rs7475294 chr10:93508199 T/C cg07889827 chr10:93443413 NA -0.38 -6.43 -0.33 4.55e-10 Intelligence (multi-trait analysis); CRC cis rs6866614 0.608 rs17132288 chr5:131336105 C/T cg02033258 chr5:131593261 PDLIM4 0.34 6.39 0.33 5.77e-10 Perceived unattractiveness to mosquitoes; CRC cis rs72634258 0.945 rs441597 chr1:8080895 A/G cg00042356 chr1:8021962 PARK7 0.61 6.95 0.36 2.02e-11 Inflammatory bowel disease; CRC cis rs225245 0.817 rs225297 chr17:33924587 G/A cg05299278 chr17:33885742 SLFN14 0.49 8.04 0.41 1.62e-14 Reticulocyte count;Reticulocyte fraction of red cells;High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells; CRC cis rs2635047 0.601 rs2635052 chr18:44650607 C/G cg23996704 chr18:44553084 KATNAL2 -0.29 -5.66 -0.3 3.29e-8 Educational attainment; CRC cis rs11122272 0.735 rs2474631 chr1:231541341 T/A cg06096015 chr1:231504339 EGLN1 0.38 5.7 0.3 2.69e-8 Hemoglobin concentration; CRC cis rs1401999 0.899 rs2313211 chr3:183738626 T/A cg01324343 chr3:183735012 ABCC5 0.82 15.07 0.64 2.24e-39 Anterior chamber depth; CRC cis rs7258465 0.965 rs8100767 chr19:18589088 T/C cg10790698 chr19:18539756 SSBP4 -0.45 -8.61 -0.43 3.07e-16 Breast cancer; CRC cis rs4975709 0.610 rs4975706 chr5:1860365 G/T cg20790798 chr5:1857306 NA -0.44 -6.7 -0.35 8.93e-11 Cardiovascular disease risk factors; CRC cis rs1816752 0.837 rs4769355 chr13:25015197 G/A cg02811702 chr13:24901961 NA 0.48 6.63 0.34 1.4e-10 Obesity-related traits; CRC trans rs6678914 1.000 rs4950774 chr1:202190546 G/A cg19977628 chr5:1262072 TERT 0.43 6.24 0.33 1.33e-9 Breast cancer (estrogen-receptor negative);Breast cancer; CRC trans rs9929218 0.954 rs9929239 chr16:68821126 C/T cg04657470 chr2:198365150 HSPE1;HSPD1 -0.79 -11.22 -0.53 5.78e-25 Colorectal cancer; CRC cis rs919433 0.680 rs2564389 chr2:198260098 A/T cg10820045 chr2:198174542 NA 0.4 6.71 0.35 8.56e-11 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC cis rs9467603 0.547 rs2039069 chr6:25424327 G/A cg16898833 chr6:26189333 HIST1H4D -0.76 -5.81 -0.3 1.5e-8 Intelligence (multi-trait analysis); CRC cis rs2842992 0.789 rs4709376 chr6:160226337 A/G cg11366901 chr6:160182831 ACAT2 0.99 14.28 0.62 2.57e-36 Age-related macular degeneration (geographic atrophy); CRC cis rs7618501 1.000 rs6446295 chr3:49809063 G/T cg24308560 chr3:49941425 MST1R -0.45 -7.01 -0.36 1.33e-11 Intelligence (multi-trait analysis); CRC cis rs7945718 0.934 rs7114040 chr11:12781659 C/T cg25843174 chr11:12811716 TEAD1 -0.47 -9.07 -0.45 1.09e-17 Educational attainment (years of education); CRC cis rs1799949 0.965 rs9911630 chr17:41188342 A/G cg07153921 chr17:41440717 NA -0.37 -5.62 -0.3 4.14e-8 Menopause (age at onset); CRC cis rs860295 0.702 rs12025532 chr1:155369302 C/T cg02153340 chr1:155202674 NA -0.58 -6.86 -0.35 3.43e-11 Body mass index; CRC cis rs11229555 0.645 rs61903159 chr11:58184475 G/A cg15696309 chr11:58395628 NA -0.81 -10.31 -0.49 8.83e-22 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; CRC cis rs1448094 1.000 rs1448094 chr12:86343135 G/T cg02569458 chr12:86230093 RASSF9 0.39 6.66 0.34 1.16e-10 Major depressive disorder; CRC cis rs28386778 0.863 rs9207 chr17:61823899 C/T cg07362569 chr17:61921086 SMARCD2 0.37 5.71 0.3 2.58e-8 Prudent dietary pattern; CRC cis rs9527 1.000 rs12416687 chr10:104629011 T/C cg15744005 chr10:104629667 AS3MT -0.39 -6.83 -0.35 4.07e-11 Arsenic metabolism; CRC cis rs9926296 0.527 rs1800335 chr16:89846195 A/G cg03388025 chr16:89894329 SPIRE2 0.43 8.62 0.43 2.84e-16 Vitiligo; CRC cis rs294883 0.858 rs12203970 chr6:159723788 A/T cg14500486 chr6:159655392 FNDC1 -0.34 -5.65 -0.3 3.55e-8 Coronary artery disease; CRC cis rs9457247 0.740 rs10946204 chr6:167451129 T/C cg07741184 chr6:167504864 NA 0.38 6.58 0.34 1.85e-10 Crohn's disease; CRC cis rs7119 0.651 rs8041398 chr15:77839173 A/G cg22256960 chr15:77711686 NA -0.42 -5.65 -0.3 3.51e-8 Type 2 diabetes; CRC cis rs6460942 0.915 rs62448621 chr7:12459941 G/A cg20607287 chr7:12443886 VWDE -0.66 -6.93 -0.36 2.17e-11 Coronary artery disease; CRC cis rs7927771 0.524 rs7118747 chr11:47889545 C/T cg20307385 chr11:47447363 PSMC3 -0.45 -6.67 -0.35 1.06e-10 Subjective well-being; CRC cis rs17433780 0.857 rs12140979 chr1:89467242 C/G cg09516651 chr1:89888402 LOC400759 0.47 6.92 0.36 2.35e-11 Carotid intima media thickness; CRC cis rs11676348 0.714 rs4674254 chr2:218986077 T/C cg00012203 chr2:219082015 ARPC2 -0.43 -6.31 -0.33 9.07e-10 Ulcerative colitis; CRC cis rs2180341 0.618 rs12199451 chr6:127597780 C/G cg27446573 chr6:127587934 RNF146 0.62 9.05 0.45 1.28e-17 Breast cancer; CRC cis rs7666738 0.830 rs2167892 chr4:99048503 G/C cg17366294 chr4:99064904 C4orf37 0.45 7.75 0.39 1.16e-13 Colonoscopy-negative controls vs population controls; CRC cis rs4713118 0.669 rs200997 chr6:27811815 G/A cg21251018 chr6:28226885 NKAPL 0.47 7.26 0.37 2.9e-12 Parkinson's disease; CRC cis rs2692947 0.759 rs2949885 chr2:96662415 A/G cg23100626 chr2:96804247 ASTL 0.25 6.88 0.35 3.09e-11 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; CRC trans rs6703335 0.870 rs10803142 chr1:243598234 A/G cg06343869 chr13:115079967 ZNF828 0.43 6.17 0.32 2.02e-9 Schizophrenia;Schizophrenia, schizoaffective disorder or bipolar disorder; CRC trans rs7267979 0.932 rs6107052 chr20:25530838 G/A cg17903999 chr18:56338584 MALT1 -0.43 -7.3 -0.37 2.22e-12 Liver enzyme levels (alkaline phosphatase); CRC cis rs7640424 0.929 rs326358 chr3:107822310 C/T cg09227934 chr3:107805635 CD47 0.43 6.5 0.34 2.98e-10 Body mass index; CRC cis rs2204008 0.837 rs11495548 chr12:38076756 C/T cg26384229 chr12:38710491 ALG10B 0.7 9.29 0.46 2.22e-18 Bladder cancer; CRC cis rs9928842 0.941 rs8057145 chr16:75256251 A/G cg08657710 chr16:75258780 CTRB1 -0.57 -6.73 -0.35 7.33e-11 Alcoholic chronic pancreatitis; CRC cis rs8031584 0.505 rs2959036 chr15:31219742 T/G cg08704250 chr15:31115839 NA 0.31 5.74 0.3 2.13e-8 Huntington's disease progression; CRC cis rs79349575 0.749 rs318093 chr17:46989354 A/G cg00947319 chr17:47005597 UBE2Z -0.34 -5.87 -0.31 1.07e-8 Type 2 diabetes; CRC trans rs561341 0.769 rs8074383 chr17:30178793 C/T cg20587970 chr11:113659929 NA 1.05 11.85 0.55 3.18e-27 Hip circumference adjusted for BMI; CRC cis rs3733585 0.648 rs28513781 chr4:9959334 G/C cg11266682 chr4:10021025 SLC2A9 -0.47 -9.67 -0.47 1.2e-19 Cleft plate (environmental tobacco smoke interaction); CRC cis rs11212617 1.000 rs186595 chr11:108251211 C/A cg12106634 chr11:108092400 ATM;NPAT 0.44 6.65 0.34 1.25e-10 Response to metformin in type 2 diabetes (glycemic); CRC cis rs2842992 0.830 rs2273819 chr6:160183325 G/C cg16489826 chr6:160211363 TCP1;MRPL18 0.49 6.15 0.32 2.22e-9 Age-related macular degeneration (geographic atrophy); CRC cis rs736408 0.609 rs13087772 chr3:52782274 T/G cg08222913 chr3:52553049 STAB1 -0.34 -6.05 -0.32 3.94e-9 Bipolar disorder; CRC trans rs2243480 1.000 rs313799 chr7:65494330 A/G cg10756647 chr7:56101905 PSPH 0.77 8.14 0.41 8.52e-15 Diabetic kidney disease; CRC cis rs12048904 0.619 rs3737581 chr1:101341083 A/G cg00063077 chr1:101360652 SLC30A7;EXTL2 0.76 11.49 0.54 6.38e-26 Multiple sclerosis; CRC trans rs3942852 0.806 rs10769316 chr11:48119745 C/G cg15704280 chr7:45808275 SEPT13 -0.61 -7.94 -0.4 3.17e-14 Acute lymphoblastic leukemia (childhood); CRC cis rs10504229 0.639 rs67996345 chr8:58117127 A/G cg21724239 chr8:58056113 NA 0.49 6.81 0.35 4.75e-11 Developmental language disorder (linguistic errors); CRC cis rs1030877 0.515 rs2576742 chr2:105898822 A/T cg02079111 chr2:105885981 TGFBRAP1 0.51 7.15 0.37 5.65e-12 Obesity-related traits; CRC cis rs9916302 0.706 rs8075737 chr17:37727316 C/T cg15445000 chr17:37608096 MED1 -0.41 -7.73 -0.39 1.29e-13 Glomerular filtration rate (creatinine); CRC cis rs10504229 0.817 rs35207430 chr8:58167614 G/A cg02290350 chr8:58132656 NA -0.44 -6.5 -0.34 3e-10 Developmental language disorder (linguistic errors); CRC cis rs10751667 0.666 rs4074231 chr11:978219 G/C cg06064525 chr11:970664 AP2A2 -0.3 -6.11 -0.32 2.78e-9 Alzheimer's disease (late onset); CRC cis rs2692947 0.702 rs2312955 chr2:96777168 T/G cg23100626 chr2:96804247 ASTL -0.29 -7.81 -0.4 7.66e-14 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; CRC cis rs6952808 0.723 rs57216949 chr7:2030287 G/T cg00106254 chr7:1943704 MAD1L1 -0.55 -8.16 -0.41 7.41e-15 Bipolar disorder and schizophrenia; CRC cis rs7617773 0.823 rs9839446 chr3:48194666 T/A cg11946769 chr3:48343235 NME6 -0.51 -6.83 -0.35 4.12e-11 Coronary artery disease; CRC cis rs2243480 1.000 rs34560516 chr7:65404092 A/T cg18252515 chr7:66147081 NA -1.07 -12.34 -0.56 5.05e-29 Diabetic kidney disease; CRC cis rs7113874 0.569 rs10840077 chr11:8601210 A/T cg02811074 chr11:8615871 STK33 0.35 6.06 0.32 3.75e-9 Body mass index in physically active individuals;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs4665809 1.000 rs6546728 chr2:26276531 G/C cg22920501 chr2:26401640 FAM59B -0.56 -7.37 -0.38 1.38e-12 Gut microbiome composition (summer); CRC cis rs4728302 0.838 rs10224828 chr7:133591071 G/A cg10665199 chr7:133106180 EXOC4 0.38 5.85 0.31 1.22e-8 Intelligence;Intelligence (multi-trait analysis); CRC cis rs7107174 1.000 rs72931642 chr11:78037862 A/T cg02023728 chr11:77925099 USP35 0.48 7.27 0.37 2.71e-12 Testicular germ cell tumor; CRC cis rs853679 0.517 rs9283884 chr6:28135660 C/G cg25164649 chr6:28176230 NA -0.76 -9.3 -0.46 1.94e-18 Depression; CRC cis rs921968 0.591 rs6717107 chr2:219588697 A/G cg02176678 chr2:219576539 TTLL4 -0.39 -6.3 -0.33 9.48e-10 Mean corpuscular hemoglobin concentration; CRC cis rs1046896 1.000 rs1046917 chr17:80685655 A/G cg03160526 chr17:80928410 B3GNTL1 -0.49 -7.31 -0.37 2e-12 Glycated hemoglobin levels; CRC cis rs9467603 0.925 rs13199775 chr6:25828782 A/T cg08501292 chr6:25962987 TRIM38 1.11 9.7 0.47 9.84e-20 Intelligence (multi-trait analysis); CRC cis rs4423214 0.592 rs10898186 chr11:71188800 G/A cg05163923 chr11:71159392 DHCR7 -0.56 -6.04 -0.32 4.28e-9 Vitamin D levels; CRC cis rs7945705 0.902 rs11042152 chr11:9020987 C/T cg12365402 chr11:9010492 NRIP3 0.53 8.78 0.44 9.43e-17 Hemoglobin concentration; CRC trans rs8035957 1.000 rs4924273 chr15:38846738 C/G cg26918957 chr8:22926800 TNFRSF10B -0.5 -6.08 -0.32 3.35e-9 Type 1 diabetes; CRC cis rs3087591 0.521 rs1013948 chr17:29530709 C/T cg24425628 chr17:29625626 OMG;NF1 0.68 9.41 0.46 8.68e-19 Hip circumference; CRC cis rs2949837 0.528 rs10260816 chr7:46010100 C/G cg21268650 chr7:45961089 IGFBP3 -0.41 -6.87 -0.35 3.21e-11 Sitting height ratio; CRC cis rs3736485 0.816 rs4143722 chr15:51867191 C/G cg08986416 chr15:51914746 DMXL2 -0.48 -6.97 -0.36 1.78e-11 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs1670533 0.769 rs6814833 chr4:1057679 A/C cg27284194 chr4:1044797 NA 0.5 6.2 0.32 1.68e-9 Recombination rate (females); CRC cis rs7584330 0.554 rs6736468 chr2:238422228 A/G cg16989719 chr2:238392110 NA -0.35 -5.73 -0.3 2.3e-8 Prostate cancer; CRC cis rs6426558 0.537 rs12139758 chr1:227260519 A/G cg10327440 chr1:227177885 CDC42BPA 0.45 6.78 0.35 5.43e-11 Neutrophil percentage of white cells; CRC cis rs45509595 0.841 rs200485 chr6:27775697 G/C cg23259851 chr6:27775964 HIST1H2AI;HIST1H2BL 0.69 5.85 0.31 1.21e-8 Breast cancer; CRC cis rs9747201 0.894 rs4503854 chr17:80178696 A/T cg23141183 chr17:80185318 SLC16A3 0.4 5.62 0.3 4.11e-8 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs1881797 1.000 rs66845073 chr1:247688010 C/T cg05639522 chr1:247681581 NA 0.46 6.95 0.36 1.91e-11 Acute lymphoblastic leukemia (childhood); CRC trans rs12639288 0.962 rs12638639 chr3:167660757 C/T cg02537909 chr2:165697595 COBLL1 -0.51 -6.07 -0.32 3.54e-9 Hirschsprung disease; CRC cis rs9322193 0.884 rs2095375 chr6:150128173 C/A cg05861140 chr6:150128134 PCMT1 -0.43 -7.05 -0.36 1.03e-11 Lung cancer; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg22624212 chr21:44298959 WDR4 0.41 6.07 0.32 3.48e-9 Intelligence (multi-trait analysis); CRC cis rs4423214 0.879 rs1792284 chr11:71134966 A/G cg13043300 chr11:71146211 DHCR7 0.48 6.53 0.34 2.45e-10 Vitamin D levels; CRC cis rs4713118 0.869 rs6902689 chr6:27709441 C/T cg08798685 chr6:27730294 NA -0.43 -6.2 -0.32 1.64e-9 Parkinson's disease; CRC cis rs7249142 0.562 rs1050544 chr19:19287901 A/G cg12558012 chr19:19281197 LOC729991-MEF2B;MEF2B 0.54 8.6 0.43 3.23e-16 IgG glycosylation; CRC cis rs919433 0.963 rs4850430 chr2:198182796 A/T cg10820045 chr2:198174542 NA -0.53 -9.12 -0.45 7.78e-18 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC trans rs6678914 1.000 rs12129536 chr1:202189338 T/C cg19977628 chr5:1262072 TERT 0.4 5.97 0.31 6.14e-9 Breast cancer (estrogen-receptor negative);Breast cancer; CRC cis rs1218582 0.772 rs4240875 chr1:154885782 G/A cg03351412 chr1:154909251 PMVK 0.54 8.73 0.43 1.27e-16 Prostate cancer; CRC cis rs9648716 1.000 rs1267603 chr7:140544447 T/C cg10747023 chr7:140774559 NA 0.43 5.61 0.3 4.2e-8 Type 2 diabetes; CRC cis rs10256972 0.732 rs1574108 chr7:1105805 T/C cg23708337 chr7:1209742 NA 0.39 5.82 0.31 1.36e-8 Longevity;Endometriosis; CRC cis rs9894429 0.646 rs7220310 chr17:79606056 C/A cg21984481 chr17:79567631 NPLOC4 -0.44 -7.62 -0.39 2.77e-13 Eye color traits; CRC cis rs10450586 0.932 rs10082611 chr11:27320108 C/G cg10370305 chr11:27303972 NA 0.35 5.76 0.3 1.98e-8 Total body bone mineral density; CRC cis rs11155671 0.530 rs6939761 chr6:150210994 T/C cg13206674 chr6:150067644 NUP43 0.49 7.04 0.36 1.13e-11 Testicular germ cell tumor; CRC cis rs4665809 0.590 rs72809668 chr2:26467653 C/T cg25036284 chr2:26402008 FAM59B 0.61 7.76 0.39 1.09e-13 Gut microbiome composition (summer); CRC trans rs3780486 0.846 rs10124479 chr9:33136233 T/G cg20290983 chr6:43655470 MRPS18A 1.16 25.31 0.81 3.42e-79 IgG glycosylation; CRC cis rs78545713 0.541 rs111465843 chr6:26222823 G/A cg01420254 chr6:26195488 NA 0.73 6.04 0.32 4.13e-9 Iron status biomarkers (total iron binding capacity); CRC cis rs9914988 0.943 rs2046759 chr17:27138817 T/C cg12682573 chr17:27188876 MIR451;MIR144 0.58 8.04 0.41 1.65e-14 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs9733 0.596 rs6692960 chr1:150695965 G/A cg17724175 chr1:150552817 MCL1 0.57 9.12 0.45 7.76e-18 Tonsillectomy; CRC cis rs12431939 0.948 rs12435444 chr14:51656071 C/T cg23942311 chr14:51606299 NA -0.53 -6.4 -0.33 5.41e-10 Cancer; CRC cis rs1552244 0.882 rs3732966 chr3:10015740 C/T cg13047869 chr3:10149882 C3orf24 0.51 6.91 0.36 2.54e-11 Alzheimer's disease; CRC cis rs6815814 0.904 rs2101521 chr4:38811551 C/T cg06935464 chr4:38784597 TLR10 0.62 7.76 0.39 1.08e-13 Breast cancer; CRC cis rs28655083 1.000 rs8045658 chr16:77056343 A/C cg01753188 chr16:77233325 SYCE1L;MON1B -0.59 -8.25 -0.41 3.77e-15 Lobe attachment (rater-scored or self-reported); CRC cis rs1862618 0.802 rs252900 chr5:56185281 T/A cg22800045 chr5:56110881 MAP3K1 0.62 6.64 0.34 1.29e-10 Initial pursuit acceleration; CRC cis rs4363385 0.747 rs1129655 chr1:152958267 T/C cg25856811 chr1:152973957 SPRR3 -0.28 -7.64 -0.39 2.38e-13 Inflammatory skin disease; CRC cis rs8060686 0.668 rs8048034 chr16:68210604 A/G cg26727032 chr16:67993705 SLC12A4 -0.6 -9.11 -0.45 8.1e-18 HDL cholesterol;Metabolic syndrome; CRC cis rs798554 0.686 rs2527690 chr7:2854250 C/T cg19717773 chr7:2847554 GNA12 -0.47 -7.91 -0.4 4.05e-14 Height; CRC cis rs2839186 0.558 rs2968 chr21:47608580 C/T cg13012494 chr21:47604986 C21orf56 -0.44 -7.08 -0.36 8.58e-12 Testicular germ cell tumor; CRC cis rs9649213 0.593 rs6967457 chr7:97912221 T/G cg24562669 chr7:97807699 LMTK2 0.47 7.9 0.4 4.14e-14 Prostate cancer (SNP x SNP interaction); CRC cis rs972578 0.837 rs1983647 chr22:43255182 T/G cg01576275 chr22:43409880 NA -0.4 -6.34 -0.33 7.65e-10 Mean platelet volume; CRC cis rs11628318 0.803 rs2277468 chr14:103024080 A/G cg23461800 chr14:103021989 NA -0.71 -9.19 -0.45 4.62e-18 Platelet count; CRC cis rs2404602 1.000 rs12594212 chr15:76802014 T/A cg03037974 chr15:76606532 NA 0.59 9.98 0.48 1.18e-20 Blood metabolite levels; CRC cis rs6502050 0.731 rs9891378 chr17:80116035 T/C cg19223190 chr17:80058835 NA 0.39 6.25 0.33 1.27e-9 Life satisfaction; CRC cis rs9649213 0.593 rs6465662 chr7:97917801 A/T cg24562669 chr7:97807699 LMTK2 0.45 7.52 0.38 5.11e-13 Prostate cancer (SNP x SNP interaction); CRC cis rs7927771 1.000 rs11039390 chr11:47796295 C/G cg18512352 chr11:47633146 NA -0.49 -9.48 -0.46 5.08e-19 Subjective well-being; CRC cis rs11252926 0.674 rs11598550 chr10:504778 A/C cg18196295 chr10:418757 DIP2C -0.54 -8.1 -0.41 1.06e-14 Psychosis in Alzheimer's disease; CRC cis rs736408 0.522 rs998909 chr3:52805093 A/G cg18099408 chr3:52552593 STAB1 -0.45 -7.54 -0.38 4.52e-13 Bipolar disorder; CRC cis rs7618915 0.547 rs11130323 chr3:52770277 T/C cg05573699 chr3:52720067 GNL3;PBRM1 -0.47 -6.74 -0.35 7.13e-11 Bipolar disorder; CRC cis rs947211 0.846 rs708726 chr1:205762139 G/T cg07167872 chr1:205819463 PM20D1 -0.44 -6.47 -0.34 3.59e-10 Parkinson's disease; CRC cis rs28386778 0.897 rs7501614 chr17:61802612 T/C cg11494091 chr17:61959527 GH2 0.61 10.2 0.49 2.05e-21 Prudent dietary pattern; CRC trans rs7301826 0.627 rs7315707 chr12:131272819 A/G cg02902800 chr4:6784175 KIAA0232 0.48 6.16 0.32 2.09e-9 Plasma plasminogen activator levels; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg25096193 chr3:16306690 OXNAD1;DPH3 0.44 6.23 0.32 1.41e-9 Anxiety disorder; CRC cis rs1552244 1.000 rs3846177 chr3:10068572 G/T cg02579736 chr3:10068473 FANCD2;CIDECP 0.95 12.63 0.57 4.38e-30 Alzheimer's disease; CRC cis rs12024301 0.557 rs12045554 chr1:183625753 G/C cg11505048 chr1:183622726 RGL1;APOBEC4 0.78 6.93 0.36 2.18e-11 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs7487075 0.718 rs4768735 chr12:46944134 G/T cg22049899 chr12:47219821 SLC38A4 -0.3 -5.98 -0.31 5.94e-9 Itch intensity from mosquito bite; CRC cis rs798554 0.759 rs1182189 chr7:2869522 G/A cg19346786 chr7:2764209 NA -0.41 -6.96 -0.36 1.9e-11 Height; CRC cis rs10504229 1.000 rs17805602 chr8:58179915 A/G cg01721255 chr8:58191610 C8orf71 0.49 6.17 0.32 2e-9 Developmental language disorder (linguistic errors); CRC cis rs728616 0.867 rs56235549 chr10:81834948 G/A cg05935833 chr10:81318306 SFTPA2 -0.59 -6.9 -0.36 2.69e-11 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs703842 1.000 rs3825079 chr12:58203354 C/T cg00677455 chr12:58241039 CTDSP2 0.64 8.72 0.43 1.44e-16 Multiple sclerosis; CRC cis rs365302 1.000 rs684052 chr6:159651247 C/T cg14500486 chr6:159655392 FNDC1 0.44 6.78 0.35 5.7e-11 Coronary heart disease; CRC cis rs919433 0.963 rs4850787 chr2:198181750 G/A cg10820045 chr2:198174542 NA -0.53 -9.51 -0.46 4.1e-19 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC cis rs11608355 0.545 rs34737994 chr12:109901621 C/T cg05360138 chr12:110035743 NA 0.77 8.7 0.43 1.65e-16 Neuroticism; CRC cis rs11971779 0.618 rs13068 chr7:139104141 G/C cg07862535 chr7:139043722 LUC7L2 0.57 7.32 0.37 1.92e-12 Diisocyanate-induced asthma; CRC cis rs4629180 0.586 rs1848699 chr2:102137903 C/G cg01388757 chr2:102091195 RFX8 -0.35 -5.65 -0.3 3.48e-8 Chronic rhinosinusitis with nasal polyps; CRC cis rs2304069 0.837 rs10041451 chr5:149385197 A/C cg22760475 chr5:149380129 HMGXB3;TIGD6 0.87 10.21 0.49 1.89e-21 HIV-1 control; CRC cis rs2282802 0.685 rs2337082 chr5:139649201 G/A cg26211634 chr5:139558579 C5orf32 0.4 6.78 0.35 5.52e-11 Intelligence (multi-trait analysis); CRC cis rs1552244 0.554 rs2272120 chr3:10046703 C/T cg18598329 chr3:10140678 FANCD2;C3orf24 -0.53 -7.53 -0.38 4.84e-13 Alzheimer's disease; CRC cis rs10479542 0.784 rs7702303 chr5:178986436 G/A cg05457628 chr5:178986728 RUFY1 0.43 7.31 0.37 2.08e-12 Lung cancer; CRC cis rs6502050 0.799 rs6502066 chr17:80103737 T/C cg09264619 chr17:80180166 NA -0.34 -5.81 -0.3 1.5e-8 Life satisfaction; CRC cis rs7552404 0.924 rs1303169 chr1:76195041 T/C cg03433033 chr1:76189801 ACADM 0.75 11.61 0.54 2.39e-26 Blood metabolite levels;Acylcarnitine levels; CRC trans rs10043228 1.000 rs6876972 chr5:115642519 C/T cg03160740 chr3:42544400 VIPR1 -0.65 -6.04 -0.32 4.18e-9 Asthma or chronic obstructive pulmonary disease; CRC cis rs7274811 0.554 rs35556109 chr20:32133489 G/A cg03904042 chr20:32255491 NECAB3;C20orf134 -0.46 -6.26 -0.33 1.23e-9 Height; CRC cis rs9902453 0.765 rs2264303 chr17:28055348 C/T cg26525008 chr17:28256777 EFCAB5;SSH2 -0.72 -12.14 -0.56 2.82e-28 Coffee consumption (cups per day); CRC cis rs9479482 0.935 rs5017315 chr6:150333574 C/T cg25797454 chr6:150327115 RAET1K 0.36 6.33 0.33 8.21e-10 Alopecia areata; CRC cis rs7208859 0.673 rs73271887 chr17:29154935 T/C cg01831904 chr17:28903510 LRRC37B2 -0.61 -6.43 -0.33 4.58e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs2933343 1.000 rs789232 chr3:128603080 T/G cg11901034 chr3:128598214 ACAD9 -0.5 -6.23 -0.32 1.44e-9 IgG glycosylation; CRC cis rs853679 0.517 rs67878650 chr6:28142587 G/C cg25164649 chr6:28176230 NA 0.78 9.69 0.47 1.04e-19 Depression; CRC cis rs172166 0.516 rs1225618 chr6:28129713 A/C cg12172441 chr6:28176163 NA 0.44 6.48 0.34 3.34e-10 Cardiac Troponin-T levels; CRC cis rs801193 0.569 rs881285 chr7:66119420 A/G cg18876405 chr7:65276391 NA -0.5 -8.05 -0.41 1.5e-14 Aortic root size; CRC cis rs12477438 0.798 rs6761570 chr2:99577276 T/G cg26064155 chr2:99771622 LIPT1;TSGA10 -0.75 -10.56 -0.5 1.23e-22 Chronic sinus infection; CRC cis rs1670533 1.000 rs13119276 chr4:1051574 T/C cg27284194 chr4:1044797 NA 0.51 6.38 0.33 6.02e-10 Recombination rate (females); CRC cis rs921968 0.541 rs12987171 chr2:219327030 G/C cg02176678 chr2:219576539 TTLL4 0.54 8.69 0.43 1.78e-16 Mean corpuscular hemoglobin concentration; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg08059820 chr3:184080810 CLCN2;POLR2H 0.49 6.76 0.35 6.35e-11 Anxiety disorder; CRC cis rs1799949 0.965 rs799910 chr17:41279561 G/C cg19454999 chr17:41278357 BRCA1;NBR2 0.4 6.22 0.32 1.49e-9 Menopause (age at onset); CRC cis rs9486719 1.000 rs12208011 chr6:96991105 G/A cg06623918 chr6:96969491 KIAA0776 -0.82 -9.56 -0.47 2.8e-19 Migraine;Coronary artery disease; CRC cis rs877282 0.898 rs11253356 chr10:768604 G/A cg17470449 chr10:769945 NA 0.58 7.98 0.4 2.53e-14 Uric acid levels; CRC cis rs9527 0.590 rs1935323 chr10:104877035 T/C cg15744005 chr10:104629667 AS3MT -0.3 -5.92 -0.31 8.19e-9 Arsenic metabolism; CRC cis rs864537 0.691 rs9662048 chr1:167412947 A/T cg09179987 chr1:167433047 CD247 -0.4 -6.14 -0.32 2.33e-9 Celiac disease or Rheumatoid arthritis;Celiac disease; CRC cis rs9522267 0.535 rs9515454 chr13:112236885 A/G cg10483660 chr13:112241077 NA -0.48 -9.0 -0.44 1.85e-17 Hepatitis; CRC cis rs939658 0.683 rs1474256 chr15:79463847 C/T cg17916960 chr15:79447300 NA 0.45 6.97 0.36 1.7e-11 Refractive error; CRC cis rs2976388 0.556 rs10956985 chr8:143818750 C/A cg15511327 chr8:143859410 LYNX1 -0.39 -6.13 -0.32 2.52e-9 Urinary tract infection frequency; CRC trans rs3743266 0.613 rs2414669 chr15:60708824 A/G cg04255276 chr11:65314021 LTBP3 0.36 6.41 0.33 5.01e-10 Menarche (age at onset); CRC cis rs1044826 0.692 rs176987 chr3:139233001 G/A cg00490450 chr3:139108681 COPB2 -0.43 -6.49 -0.34 3.11e-10 Obesity-related traits; CRC cis rs4285028 0.948 rs12497349 chr3:121708517 T/C cg11130432 chr3:121712080 ILDR1 -0.51 -6.67 -0.35 1.06e-10 Multiple sclerosis; CRC cis rs2386661 0.603 rs11259704 chr10:5646999 C/T cg26603656 chr10:5671107 NA 0.42 7.11 0.36 7.29e-12 Breast cancer; CRC trans rs2303319 0.504 rs62187656 chr2:162487699 A/G cg01191114 chr3:48936118 SLC25A20 -0.68 -5.96 -0.31 6.49e-9 Cognitive function; CRC trans rs1656966 1.000 rs1656966 chr3:186466252 C/T cg04873026 chr21:30365177 RNF160 0.43 6.66 0.34 1.13e-10 Myopia (pathological); CRC cis rs9443645 0.901 rs9361460 chr6:79589467 C/G cg05283184 chr6:79620031 NA -0.57 -9.21 -0.45 3.98e-18 Intelligence (multi-trait analysis); CRC trans rs10028773 0.515 rs9994651 chr4:120587803 C/T cg25214090 chr10:38739885 LOC399744 0.49 7.58 0.39 3.59e-13 Educational attainment; CRC cis rs7264396 0.561 rs2050930 chr20:34579397 T/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.58 -8.09 -0.41 1.15e-14 Total cholesterol levels; CRC cis rs4722166 0.645 rs1404006 chr7:22795077 T/C cg26061582 chr7:22766209 IL6 0.5 7.95 0.4 3.04e-14 Lung cancer; CRC cis rs4731207 0.564 rs1471569 chr7:124650721 A/G cg23710748 chr7:124431027 NA -0.38 -6.08 -0.32 3.27e-9 Cutaneous malignant melanoma; CRC cis rs9942416 0.660 rs10462356 chr5:74987108 C/T cg19683494 chr5:74908142 NA 0.5 6.28 0.33 1.06e-9 Age-related disease endophenotypes; CRC cis rs7493 0.950 rs7785705 chr7:95033803 A/T cg01874867 chr7:94954059 PON1 -0.52 -6.59 -0.34 1.74e-10 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs10540 1.000 rs12801271 chr11:508720 C/T cg15790184 chr11:494944 RNH1 0.61 6.24 0.33 1.35e-9 Body mass index; CRC cis rs801193 0.660 rs974239 chr7:66213491 G/A cg12463550 chr7:65579703 CRCP 0.45 6.25 0.33 1.26e-9 Aortic root size; CRC cis rs892961 0.899 rs35217221 chr17:75412385 G/A cg05865280 chr17:75406074 SEPT9 0.61 13.71 0.6 3.82e-34 Airflow obstruction; CRC cis rs597539 0.652 rs1249474 chr11:68654774 C/T cg21963583 chr11:68658836 MRPL21 0.59 10.93 0.52 6.09e-24 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs6912958 0.559 rs1201409 chr6:88055264 T/C cg04972856 chr6:88032051 C6orf162;GJB7 0.31 5.92 0.31 8.26e-9 Monocyte percentage of white cells; CRC cis rs9403521 0.898 rs3924969 chr6:143979399 C/G cg18240653 chr6:144019428 PHACTR2 -0.57 -6.47 -0.34 3.48e-10 Obesity-related traits; CRC cis rs10876993 0.890 rs12302350 chr12:58062589 T/G cg15848620 chr12:58087721 OS9 -0.63 -8.58 -0.43 3.87e-16 Celiac disease or Rheumatoid arthritis; CRC cis rs10504229 0.609 rs66477547 chr8:58105763 A/C cg22535103 chr8:58192502 C8orf71 -0.69 -8.7 -0.43 1.59e-16 Developmental language disorder (linguistic errors); CRC cis rs7949030 0.626 rs7930896 chr11:62325272 A/G cg13298116 chr11:62369859 EML3;MTA2 0.6 10.63 0.51 7.19e-23 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; CRC trans rs7937682 0.961 rs552387 chr11:111490047 T/G cg18187862 chr3:45730750 SACM1L 0.46 6.7 0.35 9.15e-11 Primary sclerosing cholangitis; CRC cis rs4713118 0.869 rs6902689 chr6:27709441 C/T cg15786705 chr6:28176104 NA 0.57 7.88 0.4 4.81e-14 Parkinson's disease; CRC cis rs2842992 0.789 rs2146163 chr6:160224346 T/C cg16489826 chr6:160211363 TCP1;MRPL18 0.49 6.14 0.32 2.32e-9 Age-related macular degeneration (geographic atrophy); CRC cis rs13108904 0.901 rs4974594 chr4:1300480 C/T cg21620606 chr4:1342894 KIAA1530 -0.37 -6.49 -0.34 3.18e-10 Obesity-related traits; CRC trans rs2727020 0.786 rs10839263 chr11:49354462 A/G cg15704280 chr7:45808275 SEPT13 -0.74 -9.85 -0.48 3.02e-20 Coronary artery disease; CRC cis rs1881797 0.932 rs10925071 chr1:247686521 C/T cg11166453 chr1:247681781 NA -0.49 -9.04 -0.45 1.41e-17 Acute lymphoblastic leukemia (childhood); CRC cis rs17065868 0.764 rs55633498 chr13:45020560 G/A cg10246903 chr13:45222710 NA 0.59 5.83 0.31 1.33e-8 Antineutrophil cytoplasmic antibody-associated vasculitis; CRC cis rs524281 0.692 rs10791845 chr11:65834340 C/G cg16950941 chr11:66035639 RAB1B 0.57 7.9 0.4 4.34e-14 Electroencephalogram traits; CRC cis rs990171 0.913 rs2272128 chr2:103039929 G/A cg03938978 chr2:103052716 IL18RAP 0.45 5.68 0.3 2.97e-8 Lymphocyte counts; CRC cis rs3087591 0.708 rs10438801 chr17:29693785 G/A cg24425628 chr17:29625626 OMG;NF1 0.7 12.97 0.58 2.27e-31 Hip circumference; CRC cis rs1707322 1.000 rs12124291 chr1:46432132 G/A cg03146154 chr1:46216737 IPP 0.51 7.09 0.36 8.01e-12 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC trans rs10983614 1.000 rs7867776 chr9:120072627 A/G cg08206623 chr11:2907334 CDKN1C 0.43 6.17 0.32 1.97e-9 Survival in pancreatic cancer; CRC cis rs10751667 0.666 rs10902242 chr11:949700 G/A cg23136738 chr11:925521 AP2A2 -0.41 -7.01 -0.36 1.32e-11 Alzheimer's disease (late onset); CRC cis rs7959452 0.536 rs4761237 chr12:69776461 C/G cg22834771 chr12:69754056 YEATS4 -0.54 -8.11 -0.41 1e-14 Blood protein levels; CRC cis rs4722166 0.695 rs7787893 chr7:22774437 A/G cg05472934 chr7:22766657 IL6 0.67 11.03 0.52 2.73e-24 Lung cancer; CRC cis rs11628318 0.853 rs7155171 chr14:103031845 C/T cg02094049 chr14:103021097 NA -0.56 -7.51 -0.38 5.44e-13 Platelet count; CRC cis rs56399783 0.901 rs17241904 chr7:2875574 C/T cg19731401 chr7:2775893 GNA12 0.61 6.46 0.34 3.72e-10 Childhood ear infection; CRC cis rs57561814 1.000 rs57561814 chr7:22753675 G/C cg26061582 chr7:22766209 IL6 0.78 6.37 0.33 6.26e-10 Tonsillectomy; CRC cis rs6456156 0.524 rs6932740 chr6:167466439 G/A cg07741184 chr6:167504864 NA 0.39 6.89 0.35 2.93e-11 Primary biliary cholangitis; CRC cis rs6502050 0.835 rs7220639 chr17:80146866 G/A cg25804541 chr17:80189381 SLC16A3 -0.3 -5.71 -0.3 2.57e-8 Life satisfaction; CRC cis rs4713118 0.614 rs9380007 chr6:27660508 T/C cg15786705 chr6:28176104 NA 0.47 6.82 0.35 4.5e-11 Parkinson's disease; CRC cis rs727505 1.000 rs67552763 chr7:124517857 A/G cg23710748 chr7:124431027 NA -0.8 -14.18 -0.62 6.24e-36 Lewy body disease; CRC cis rs9291683 0.679 rs13137795 chr4:10051506 G/A cg00071950 chr4:10020882 SLC2A9 0.64 12.0 0.55 8.93e-28 Bone mineral density; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T ch.12.1569034F chr12:77413631 NA 0.44 6.4 0.33 5.5e-10 Intelligence (multi-trait analysis); CRC cis rs875971 0.545 rs7810213 chr7:65946579 G/C cg05627663 chr7:65219948 SNORA22;CCT6P1 0.59 7.52 0.38 5.37e-13 Aortic root size; CRC cis rs7666738 0.830 rs1426668 chr4:98945585 T/A cg05340658 chr4:99064831 C4orf37 0.61 9.54 0.47 3.45e-19 Colonoscopy-negative controls vs population controls; CRC trans rs17106184 1.000 rs59786222 chr1:51295793 C/T cg02869289 chr19:46177325 MIR642;GIPR 0.62 6.07 0.32 3.51e-9 Type 2 diabetes; CRC cis rs3785574 0.962 rs62077512 chr17:61851435 C/T cg06873352 chr17:61820015 STRADA 0.5 8.04 0.41 1.66e-14 Height; CRC cis rs13082711 0.554 rs35840701 chr3:27334231 A/C cg02860705 chr3:27208620 NA 0.82 10.82 0.51 1.5e-23 Systolic blood pressure;Diastolic blood pressure;Blood pressure; CRC cis rs6582630 0.519 rs10880194 chr12:38302836 G/A cg26384229 chr12:38710491 ALG10B 0.69 9.77 0.47 5.73e-20 Drug-induced liver injury (flucloxacillin); CRC cis rs977987 0.843 rs11860231 chr16:75385159 A/G cg03315344 chr16:75512273 CHST6 0.52 8.8 0.44 7.68e-17 Dupuytren's disease; CRC cis rs4665809 1.000 rs11678157 chr2:26321526 T/C cg26119090 chr2:26468346 HADHA;HADHB -0.6 -7.88 -0.4 4.77e-14 Gut microbiome composition (summer); CRC cis rs77633900 0.614 rs1443110 chr15:76928322 C/T cg21673338 chr15:77095150 SCAPER 0.69 7.31 0.37 2.04e-12 Non-glioblastoma glioma;Glioma; CRC cis rs7786808 0.782 rs7787923 chr7:158227312 A/G cg01191920 chr7:158217561 PTPRN2 -0.78 -15.16 -0.64 9.45e-40 Obesity-related traits; CRC trans rs924135 0.634 rs246221 chr16:16138322 T/C cg06794141 chr16:77535527 NA 0.39 5.98 0.31 5.77e-9 White blood cell count (basophil);Blood metabolite levels; CRC trans rs1814175 0.817 rs28525029 chr11:50045815 A/G cg03929089 chr4:120376271 NA -0.96 -19.27 -0.73 6.37e-56 Height; CRC cis rs3096299 0.719 rs2353581 chr16:89518908 T/C cg02187348 chr16:89574699 SPG7 0.4 5.95 0.31 7.01e-9 Multiple myeloma (IgH translocation); CRC cis rs891088 0.695 rs28695870 chr19:7197988 C/T cg09779027 chr19:7224513 INSR -0.59 -7.31 -0.37 2.1e-12 Hip circumference adjusted for BMI;Height; CRC cis rs6502050 0.799 rs6416859 chr17:80111442 G/C cg22110888 chr17:80059540 CCDC57 0.4 6.44 0.33 4.17e-10 Life satisfaction; CRC cis rs1448094 0.512 rs7133591 chr12:86239752 G/C cg18827107 chr12:86230957 RASSF9 -0.46 -7.54 -0.38 4.63e-13 Major depressive disorder; CRC cis rs992157 0.798 rs10932772 chr2:219177148 C/T cg00012203 chr2:219082015 ARPC2 0.43 6.56 0.34 2.03e-10 Colorectal cancer; CRC cis rs9733 0.650 rs11204668 chr1:150543686 G/A cg17724175 chr1:150552817 MCL1 -0.53 -8.51 -0.42 6.16e-16 Tonsillectomy; CRC cis rs2769264 0.602 rs11204777 chr1:151072049 G/A cg11822372 chr1:151115635 SEMA6C 0.46 5.75 0.3 2.02e-8 Blood trace element (Cu levels); CRC cis rs7811142 1.000 rs11763414 chr7:100016844 C/G cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.16 17.33 0.69 2.96e-48 Platelet count; CRC cis rs7312933 1.000 rs7957213 chr12:42475438 T/G cg17420585 chr12:42539391 GXYLT1 -0.43 -6.2 -0.32 1.68e-9 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CRC cis rs62244186 0.711 rs6778410 chr3:44743993 C/T cg18722847 chr3:44754129 ZNF502 -0.34 -5.74 -0.3 2.17e-8 Depressive symptoms; CRC cis rs3741404 0.620 rs2236648 chr11:63964657 C/T cg19465662 chr11:63993652 NUDT22;TRPT1 0.74 11.83 0.55 3.97e-27 Platelet count; CRC cis rs7937682 0.663 rs3867466 chr11:111668256 A/C cg09085632 chr11:111637200 PPP2R1B 0.96 15.32 0.65 2.31e-40 Primary sclerosing cholangitis; CRC trans rs7615952 0.546 rs2979333 chr3:125360343 T/A cg00769240 chr8:12517080 NA -0.68 -7.78 -0.39 9.14e-14 Blood pressure (smoking interaction); CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg19082920 chr1:202830751 LOC148709 0.45 6.01 0.31 4.82e-9 Thyroid stimulating hormone; CRC cis rs55702914 0.712 rs10931778 chr2:198148922 C/T cg03934865 chr2:198174659 NA -0.4 -6.93 -0.36 2.28e-11 Major depression and alcohol dependence; CRC cis rs477895 0.653 rs11231701 chr11:63893702 G/A cg04317338 chr11:64019027 PLCB3 0.6 7.37 0.38 1.35e-12 Mean platelet volume; CRC cis rs1881797 1.000 rs12071797 chr1:247686871 A/G cg11166453 chr1:247681781 NA 0.43 7.0 0.36 1.48e-11 Acute lymphoblastic leukemia (childhood); CRC cis rs1218582 0.772 rs4845693 chr1:154911257 A/G cg09359103 chr1:154839909 KCNN3 0.73 12.71 0.57 2.18e-30 Prostate cancer; CRC cis rs763121 1.000 rs1946990 chr22:38912771 C/T cg06544989 chr22:39130855 UNC84B -0.47 -7.92 -0.4 3.63e-14 Menopause (age at onset); CRC cis rs62408225 0.963 rs1321859 chr6:91011673 C/T cg06866423 chr6:90926672 BACH2 0.5 8.33 0.42 2.28e-15 Eosinophil counts;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC cis rs7618915 0.524 rs12488461 chr3:52698417 T/C cg11645453 chr3:52864694 ITIH4 0.37 6.41 0.33 4.91e-10 Bipolar disorder; CRC cis rs7224685 0.501 rs6502765 chr17:3901814 A/G cg10724054 chr17:3904396 NA -0.46 -7.57 -0.39 3.71e-13 Type 2 diabetes; CRC trans rs2908835 0.503 rs73056812 chr12:11609577 C/A cg03979024 chr10:419189 DIP2C -0.39 -6.07 -0.32 3.45e-9 Information processing speed; CRC cis rs651907 0.557 rs59596156 chr3:101394217 C/T cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.68 9.29 0.46 2.12e-18 Colorectal cancer; CRC cis rs7707921 1.000 rs4703879 chr5:81553815 C/T cg17942617 chr5:81327376 ATG10 0.4 5.87 0.31 1.06e-8 Breast cancer; CRC cis rs4713118 0.539 rs510987 chr6:27847517 G/A cg23161317 chr6:28129485 ZNF389 0.43 5.98 0.31 5.95e-9 Parkinson's disease; CRC cis rs9858542 1.000 rs9812791 chr3:49682311 G/A cg07274523 chr3:49395745 GPX1 0.46 6.02 0.31 4.74e-9 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs8141797 0.748 rs3788368 chr22:24577986 T/C cg20894457 chr22:24584366 SUSD2 0.6 7.66 0.39 2.09e-13 Amyotrophic lateral sclerosis;Coronary artery disease; CRC cis rs8077889 1.000 rs17742905 chr17:41891143 C/A cg16892393 chr17:41919603 NA 0.61 8.97 0.44 2.31e-17 Triglycerides; CRC cis rs8044868 0.586 rs7200854 chr16:72083318 G/A cg06172871 chr16:72088244 HP 0.44 6.45 0.33 4.08e-10 Body mass index (change over time) in cancer or chronic obstructive pulmonary disease;Body mass index (change over time) in cancer; CRC cis rs4434138 0.683 rs13063160 chr3:52602274 T/C cg18099408 chr3:52552593 STAB1 -0.46 -7.98 -0.4 2.44e-14 Intelligence (multi-trait analysis); CRC trans rs61931739 0.500 rs6488221 chr12:34525671 A/G cg13010199 chr12:38710504 ALG10B 0.45 6.52 0.34 2.6e-10 Morning vs. evening chronotype; CRC cis rs6570726 0.764 rs367065 chr6:145882309 T/G cg13319975 chr6:146136371 FBXO30 -0.44 -6.52 -0.34 2.66e-10 Lobe attachment (rater-scored or self-reported); CRC trans rs561341 1.000 rs2344312 chr17:30243583 G/T cg20587970 chr11:113659929 NA -0.95 -13.66 -0.6 5.9e-34 Hip circumference adjusted for BMI; CRC cis rs11212617 0.967 rs227053 chr11:108226855 A/T cg01991180 chr11:108092276 ATM;NPAT 0.41 6.01 0.31 4.96e-9 Response to metformin in type 2 diabetes (glycemic); CRC cis rs780096 0.545 rs2280737 chr2:27589810 A/G cg21248554 chr2:27665150 KRTCAP3 -0.27 -6.24 -0.33 1.32e-9 Total body bone mineral density; CRC cis rs2635047 0.638 rs9956809 chr18:44655843 A/G cg23996704 chr18:44553084 KATNAL2 -0.29 -5.66 -0.3 3.29e-8 Educational attainment; CRC cis rs12541335 0.639 rs7834182 chr8:22163112 G/A cg09517075 chr8:22133004 PIWIL2 0.48 8.41 0.42 1.25e-15 Hypertriglyceridemia; CRC cis rs210142 1.000 rs210142 chr6:33546837 T/C cg07679836 chr6:33548423 BAK1 0.35 5.79 0.3 1.65e-8 Platelet count;Plateletcrit;Chronic lymphocytic leukemia; CRC cis rs7927592 0.956 rs10896341 chr11:68313180 G/A cg16797656 chr11:68205561 LRP5 0.36 5.71 0.3 2.55e-8 Total body bone mineral density; CRC cis rs7772486 0.754 rs6570708 chr6:145989428 C/T cg13319975 chr6:146136371 FBXO30 0.45 6.54 0.34 2.4e-10 Lobe attachment (rater-scored or self-reported); CRC cis rs7772486 0.790 rs1133832 chr6:146205604 C/T cg13319975 chr6:146136371 FBXO30 0.38 5.78 0.3 1.69e-8 Lobe attachment (rater-scored or self-reported); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg06748153 chr16:50279807 NA 0.39 6.58 0.34 1.87e-10 Liver disease severity in Alagille syndrome; CRC cis rs1712517 0.873 rs1712510 chr10:105009086 A/G cg05636881 chr10:105038444 INA -0.49 -8.81 -0.44 7.1e-17 Migraine; CRC cis rs2455601 0.638 rs2742478 chr11:8996099 G/C cg21881798 chr11:8931708 C11orf17;ST5 -0.53 -6.25 -0.33 1.29e-9 Schizophrenia; CRC cis rs2462686 0.965 rs1534151 chr7:45984645 A/G cg23193639 chr7:45961078 IGFBP3 -0.37 -5.74 -0.3 2.2e-8 Major depressive disorder; CRC cis rs4722166 0.630 rs7781534 chr7:22778592 A/C cg05472934 chr7:22766657 IL6 0.76 12.37 0.56 4.12e-29 Lung cancer; CRC cis rs875971 0.767 rs1695815 chr7:65831344 A/G cg00343986 chr7:65444356 GUSB 0.43 6.3 0.33 9.66e-10 Aortic root size; CRC cis rs7811142 0.830 rs6955367 chr7:99961194 A/G cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.08 16.52 0.67 4.73e-45 Platelet count; CRC cis rs9322193 0.886 rs17672976 chr6:150097343 T/A cg13206674 chr6:150067644 NUP43 0.57 8.14 0.41 8.29e-15 Lung cancer; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg18803079 chr1:64014643 EFCAB7;DLEU2L -0.4 -6.35 -0.33 6.96e-10 Liver disease severity in Alagille syndrome; CRC cis rs7618501 1.000 rs11709680 chr3:49745188 C/T cg24308560 chr3:49941425 MST1R 0.45 7.2 0.37 4.09e-12 Intelligence (multi-trait analysis); CRC cis rs7727544 0.716 rs4705928 chr5:131578637 A/G cg11843238 chr5:131593191 PDLIM4 -0.35 -6.42 -0.33 4.78e-10 Blood metabolite levels; CRC cis rs1799949 1.000 rs11653069 chr17:41283377 C/T cg05368731 chr17:41323189 NBR1 0.69 10.48 0.5 2.22e-22 Menopause (age at onset); CRC cis rs2762353 0.505 rs2096386 chr6:25787817 C/T cg16482183 chr6:26056742 HIST1H1C -0.54 -7.43 -0.38 9.26e-13 Blood metabolite levels; CRC cis rs1862618 0.525 rs832403 chr5:56265992 G/T cg12311346 chr5:56204834 C5orf35 0.88 11.77 0.54 6.28e-27 Initial pursuit acceleration; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg11784697 chr19:1104586 GPX4 0.44 6.03 0.32 4.4e-9 Anxiety disorder; CRC cis rs11098499 0.954 rs10008459 chr4:120394231 T/C cg09307838 chr4:120376055 NA 0.71 11.09 0.52 1.73e-24 Corneal astigmatism; CRC cis rs6460942 0.915 rs7803002 chr7:12306738 C/T cg06484146 chr7:12443880 VWDE -0.54 -7.09 -0.36 8.29e-12 Coronary artery disease; CRC trans rs11098499 0.954 rs13151285 chr4:120314741 C/A cg25214090 chr10:38739885 LOC399744 0.62 9.74 0.47 7.35e-20 Corneal astigmatism; CRC trans rs6956675 0.957 rs28541324 chr7:62608767 G/A cg01314568 chr7:57830625 NA -0.69 -9.26 -0.45 2.68e-18 Obesity-related traits; CRC cis rs9611565 0.694 rs202613 chr22:41821993 C/A cg06634786 chr22:41940651 POLR3H 0.7 7.77 0.39 1.03e-13 Vitiligo; CRC cis rs116095464 0.558 rs10055993 chr5:264296 A/C cg22857025 chr5:266934 NA -1.2 -12.13 -0.56 3.02e-28 Breast cancer; CRC cis rs1005277 0.579 rs2472175 chr10:38382901 T/G cg17219203 chr10:38645113 HSD17B7P2 -0.41 -5.76 -0.3 1.89e-8 Extrinsic epigenetic age acceleration; CRC cis rs4713118 0.662 rs149970 chr6:27980220 C/T cg02683197 chr6:28174875 NA 0.69 9.03 0.45 1.53e-17 Parkinson's disease; CRC cis rs7959452 0.535 rs10784771 chr12:69621264 A/G cg22834771 chr12:69754056 YEATS4 -0.4 -5.77 -0.3 1.82e-8 Blood protein levels; CRC cis rs1865760 0.663 rs9467656 chr6:25993559 G/A cg18357526 chr6:26021779 HIST1H4A 0.41 5.99 0.31 5.41e-9 Height; CRC cis rs8180040 0.966 rs1872164 chr3:47415100 G/A cg10298567 chr3:47292165 KIF9 0.38 6.17 0.32 2.03e-9 Colorectal cancer; CRC cis rs6912958 0.781 rs9444522 chr6:88309705 G/A cg12350822 chr6:88032061 C6orf162;GJB7 -0.33 -6.27 -0.33 1.1e-9 Monocyte percentage of white cells; CRC cis rs10464366 0.517 rs13231075 chr7:39174806 G/T cg15212455 chr7:39170539 POU6F2 0.5 6.56 0.34 2.03e-10 IgG glycosylation; CRC cis rs977987 0.771 rs4888387 chr16:75389755 T/G cg03315344 chr16:75512273 CHST6 0.52 8.73 0.43 1.29e-16 Dupuytren's disease; CRC cis rs1552244 1.000 rs4269070 chr3:10126083 C/G cg02579736 chr3:10068473 FANCD2;CIDECP 0.97 13.18 0.59 3.68e-32 Alzheimer's disease; CRC trans rs1814175 0.817 rs4084376 chr11:49831160 T/C cg11707556 chr5:10655725 ANKRD33B -0.43 -8.07 -0.41 1.31e-14 Height; CRC cis rs4589502 1.000 rs75502100 chr15:67131417 T/C cg12317470 chr15:67143691 NA 0.79 6.87 0.35 3.26e-11 Lung cancer (smoking interaction); CRC cis rs7917772 0.503 rs2031602 chr10:104307955 G/C cg11453585 chr10:104263688 ACTR1A;SUFU 0.89 17.29 0.69 4.24e-48 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC cis rs25422 0.938 rs62424176 chr6:118798602 T/C cg07617317 chr6:118971624 C6orf204 0.51 6.32 0.33 8.53e-10 Renal cell carcinoma; CRC cis rs9902453 0.817 rs7217961 chr17:28403112 T/C cg26525008 chr17:28256777 EFCAB5;SSH2 -0.69 -11.43 -0.53 1.03e-25 Coffee consumption (cups per day); CRC cis rs1552172 0.853 rs913513 chr1:145595423 G/A cg11743829 chr1:145714124 CD160 0.36 5.75 0.3 2.06e-8 Breast cancer; CRC cis rs1707322 0.717 rs2991989 chr1:46082965 C/T cg03146154 chr1:46216737 IPP -0.67 -9.51 -0.46 4.3e-19 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs11098499 0.954 rs11935596 chr4:120412457 G/C cg24375607 chr4:120327624 NA 0.49 7.5 0.38 6.06e-13 Corneal astigmatism; CRC cis rs6952808 0.792 rs12531315 chr7:1953650 C/G cg04267008 chr7:1944627 MAD1L1 -0.84 -12.87 -0.58 5.48e-31 Bipolar disorder and schizophrenia; CRC cis rs28386778 1.000 rs28386778 chr17:61964815 T/C cg22520471 chr17:61851767 DDX42;CCDC47 0.74 10.95 0.52 5.42e-24 Prudent dietary pattern; CRC cis rs7666738 0.830 rs7687315 chr4:98900613 A/G cg05340658 chr4:99064831 C4orf37 0.58 8.82 0.44 6.96e-17 Colonoscopy-negative controls vs population controls; CRC cis rs7215564 0.818 rs1032130 chr17:78610636 A/G cg09596252 chr17:78655493 RPTOR -0.64 -6.33 -0.33 8.02e-10 Myopia (pathological); CRC cis rs12477438 0.501 rs7608938 chr2:99782226 C/T cg14399236 chr2:99771627 LIPT1;TSGA10 0.73 12.17 0.56 2.24e-28 Chronic sinus infection; CRC cis rs9911578 1.000 rs1267545 chr17:56646909 A/G cg05425664 chr17:57184151 TRIM37 -0.51 -8.06 -0.41 1.39e-14 Intelligence (multi-trait analysis); CRC cis rs7503807 0.515 rs12601001 chr17:78681084 T/C cg00549398 chr17:78725201 RPTOR 0.43 5.77 0.3 1.86e-8 Obesity; CRC cis rs12950390 0.893 rs4239166 chr17:45847329 A/G cg24803719 chr17:45855879 NA -0.3 -6.5 -0.34 3.03e-10 IgG glycosylation; CRC cis rs4713118 0.824 rs9468229 chr6:27750086 G/A cg12273811 chr6:28175739 NA 0.5 6.63 0.34 1.38e-10 Parkinson's disease; CRC cis rs72717009 0.825 rs7515174 chr1:161476949 C/G cg23840854 chr1:161414152 NA -0.67 -8.14 -0.41 8.07e-15 Rheumatoid arthritis; CRC cis rs7215564 0.908 rs4969411 chr17:78747982 T/C cg09596252 chr17:78655493 RPTOR -0.55 -5.79 -0.3 1.65e-8 Myopia (pathological); CRC cis rs736408 0.677 rs678 chr3:52820981 A/T cg15147215 chr3:52552868 STAB1 -0.58 -8.98 -0.44 2.18e-17 Bipolar disorder; CRC cis rs1799949 1.000 rs9646417 chr17:41424253 G/A cg01879757 chr17:41196368 BRCA1 -0.41 -6.0 -0.31 5.15e-9 Menopause (age at onset); CRC cis rs3741404 0.620 rs2236647 chr11:63964605 A/G cg20160996 chr11:63990575 FERMT3 0.38 6.21 0.32 1.57e-9 Platelet count; CRC cis rs9733 0.566 rs112967224 chr1:150677263 G/A cg10589385 chr1:150898437 SETDB1 0.3 6.24 0.33 1.34e-9 Tonsillectomy; CRC trans rs61931739 0.500 rs10844864 chr12:34532468 A/G cg26384229 chr12:38710491 ALG10B 0.59 8.77 0.44 9.64e-17 Morning vs. evening chronotype; CRC cis rs9326248 0.861 rs7120309 chr11:117042816 T/A cg11861562 chr11:117069780 TAGLN 0.34 6.34 0.33 7.39e-10 Blood protein levels; CRC cis rs13191362 0.935 rs13219926 chr6:163004213 T/C cg06582575 chr6:163149167 PACRG;PARK2 0.77 10.59 0.5 9.54e-23 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs225245 0.817 rs225269 chr17:33967931 G/T cg05299278 chr17:33885742 SLFN14 0.49 7.89 0.4 4.48e-14 Reticulocyte count;Reticulocyte fraction of red cells;High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells; CRC cis rs7605827 0.897 rs11885852 chr2:15515371 A/C cg19274914 chr2:15703543 NA 0.4 6.05 0.32 3.97e-9 Educational attainment (years of education); CRC cis rs12410462 0.681 rs4614224 chr1:227574966 C/T cg23173402 chr1:227635558 NA 0.69 6.51 0.34 2.84e-10 Major depressive disorder; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg26816438 chr1:45139524 TMEM53;C1orf228 0.41 6.21 0.32 1.61e-9 Intelligence (multi-trait analysis); CRC cis rs6951245 0.935 rs61753396 chr7:1105372 A/G cg03188948 chr7:1209495 NA 0.65 6.85 0.35 3.68e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs12188164 0.686 rs72711367 chr5:418494 A/G cg21972741 chr5:435613 AHRR 0.5 6.67 0.35 1.08e-10 Cystic fibrosis severity; CRC cis rs4862750 0.872 rs4862748 chr4:187877388 C/T cg22105103 chr4:187893119 NA -0.63 -10.4 -0.5 4.34e-22 Lobe attachment (rater-scored or self-reported); CRC cis rs4481887 0.893 rs7528645 chr1:248427291 T/A cg13385794 chr1:248469461 NA 0.41 7.28 0.37 2.46e-12 Common traits (Other); CRC cis rs1348850 0.750 rs12997716 chr2:178494629 G/A cg02961200 chr2:178257176 LOC100130691;AGPS 0.52 7.37 0.38 1.42e-12 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs10504229 0.683 rs11786527 chr8:58131344 G/C cg05313129 chr8:58192883 C8orf71 -0.44 -6.05 -0.32 3.92e-9 Developmental language disorder (linguistic errors); CRC trans rs66573146 0.901 rs7668802 chr4:6986236 T/A cg07817883 chr1:32538562 TMEM39B 1.7 13.65 0.6 6.13e-34 Granulocyte percentage of myeloid white cells; CRC cis rs1008375 0.898 rs2079892 chr4:17577163 G/A cg16339924 chr4:17578868 LAP3 0.6 8.0 0.4 2.16e-14 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs10242455 0.702 rs6976017 chr7:99249999 G/A cg18809830 chr7:99032528 PTCD1 -1.04 -7.34 -0.38 1.68e-12 Blood metabolite levels; CRC cis rs738322 0.555 rs5750549 chr22:38547172 C/T cg03162506 chr22:38580953 NA 0.28 5.98 0.31 5.7e-9 Cutaneous nevi; CRC cis rs2180341 1.000 rs2326567 chr6:127606160 G/A cg24812749 chr6:127587940 RNF146 0.94 13.67 0.6 5.36e-34 Breast cancer; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg06931245 chr8:28351501 FZD3 0.4 6.11 0.32 2.74e-9 Liver disease severity in Alagille syndrome; CRC trans rs2303319 0.504 rs62189054 chr2:162624654 C/G cg23919916 chr10:103825097 HPS6 -0.69 -5.99 -0.31 5.54e-9 Cognitive function; CRC cis rs427941 0.655 rs201468 chr7:101742673 C/T cg06246474 chr7:101738831 CUX1 0.45 7.03 0.36 1.22e-11 Plasma omega-3 polyunsaturated fatty acid level (eicosapentaenoic acid); CRC cis rs9322193 0.923 rs7767622 chr6:150002902 T/C cg00933542 chr6:150070202 PCMT1 0.31 6.38 0.33 6.16e-10 Lung cancer; CRC cis rs2839186 0.721 rs3788252 chr21:47661235 C/T cg13012494 chr21:47604986 C21orf56 0.46 7.29 0.37 2.36e-12 Testicular germ cell tumor; CRC cis rs875971 0.862 rs35378740 chr7:65987712 C/A cg18876405 chr7:65276391 NA 0.52 8.38 0.42 1.6e-15 Aortic root size; CRC cis rs1799949 0.894 rs8176160 chr17:41241503 T/C cg19454999 chr17:41278357 BRCA1;NBR2 0.57 8.9 0.44 3.69e-17 Menopause (age at onset); CRC cis rs13191362 0.507 rs2023037 chr6:163120385 C/T cg21926612 chr6:163149169 PACRG;PARK2 0.57 8.94 0.44 2.88e-17 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs7191439 0.789 rs4433802 chr16:88784964 A/G cg27087555 chr16:88793112 FAM38A -1.49 -13.43 -0.6 4.33e-33 Plateletcrit; CRC cis rs2933343 0.553 rs789212 chr3:128686912 A/C cg11901034 chr3:128598214 ACAD9 -0.61 -8.06 -0.41 1.4e-14 IgG glycosylation; CRC cis rs2806561 1.000 rs1757048 chr1:23510601 A/C cg19743168 chr1:23544995 NA 0.37 6.0 0.31 5.21e-9 Height; CRC cis rs7727544 0.716 rs2089855 chr5:131573529 A/G cg09877947 chr5:131593287 PDLIM4 0.34 6.06 0.32 3.71e-9 Blood metabolite levels; CRC cis rs1552244 1.000 rs17032277 chr3:10077023 T/C cg13047869 chr3:10149882 C3orf24 0.57 7.76 0.39 1.1e-13 Alzheimer's disease; CRC cis rs6951245 1.000 rs79443843 chr7:1075245 G/A cg03188948 chr7:1209495 NA 0.63 6.51 0.34 2.76e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC trans rs7395662 0.963 rs7952491 chr11:48663295 T/A cg21153622 chr11:89784906 NA -0.44 -7.09 -0.36 8.39e-12 HDL cholesterol; CRC cis rs7020830 0.931 rs1388978 chr9:37144062 G/T cg14294708 chr9:37120828 ZCCHC7 1.05 19.88 0.74 2.52e-58 Schizophrenia; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg13331940 chr15:59663987 MYO1E 0.4 6.35 0.33 7.06e-10 Liver disease severity in Alagille syndrome; CRC cis rs1799949 1.000 rs12944458 chr17:41180772 C/T cg05368731 chr17:41323189 NBR1 0.69 10.07 0.49 5.76e-21 Menopause (age at onset); CRC cis rs9372498 0.536 rs13437605 chr6:118899014 C/T cg22561889 chr6:118971681 C6orf204 0.5 6.43 0.33 4.51e-10 Diastolic blood pressure; CRC cis rs2456568 0.778 rs7940973 chr11:93682045 C/G cg26875233 chr11:93583750 C11orf90 0.3 5.64 0.3 3.76e-8 Response to serotonin reuptake inhibitors in major depressive disorder; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg21732842 chr11:47198564 ARFGAP2 -0.43 -6.68 -0.35 1.04e-10 Myopia (pathological); CRC cis rs67478160 0.619 rs11628481 chr14:104241499 C/T cg08213375 chr14:104286397 PPP1R13B 0.65 13.67 0.6 5.24e-34 Schizophrenia; CRC cis rs1059312 1.000 rs12814773 chr12:129280786 C/T cg21616243 chr12:129299702 MGC16384;SLC15A4 -0.65 -10.69 -0.51 4.17e-23 Systemic lupus erythematosus; CRC cis rs6685188 0.920 rs6676110 chr1:205662977 G/A cg07167872 chr1:205819463 PM20D1 -0.44 -6.22 -0.32 1.48e-9 White blood cell count (basophil);Basophil percentage of white cells; CRC cis rs13191362 0.935 rs13215748 chr6:163010710 A/C cg21926612 chr6:163149169 PACRG;PARK2 0.78 10.8 0.51 1.77e-23 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs9916302 0.821 rs412430 chr17:37737094 C/G cg15445000 chr17:37608096 MED1 0.43 9.31 0.46 1.8e-18 Glomerular filtration rate (creatinine); CRC trans rs1814175 0.791 rs10219223 chr11:49791468 A/T cg03929089 chr4:120376271 NA -0.94 -18.03 -0.7 5.18e-51 Height; CRC cis rs2839186 0.609 rs2839189 chr21:47694357 C/T cg09417038 chr21:47716443 C21orf57 0.56 9.2 0.45 4.3e-18 Testicular germ cell tumor; CRC cis rs2067615 0.579 rs10778506 chr12:107143260 T/C cg13491945 chr12:107078410 RFX4 0.35 5.94 0.31 7.11e-9 Heart rate; CRC cis rs40363 0.723 rs4785936 chr16:3535116 A/G cg00484396 chr16:3507460 NAT15 -0.57 -5.88 -0.31 9.9e-9 Tuberculosis; CRC cis rs9894429 0.646 rs7406522 chr17:79615396 G/T cg21984481 chr17:79567631 NPLOC4 -0.42 -7.23 -0.37 3.36e-12 Eye color traits; CRC cis rs8180040 0.654 rs6791062 chr3:47174343 T/A cg27129171 chr3:47204927 SETD2 0.72 11.51 0.54 5.51e-26 Colorectal cancer; CRC cis rs4727027 0.736 rs12704084 chr7:148915050 C/G cg23583168 chr7:148888333 NA -0.88 -16.3 -0.67 3.23e-44 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC cis rs10504229 0.728 rs17804666 chr8:58154473 C/T cg21724239 chr8:58056113 NA 0.62 8.38 0.42 1.51e-15 Developmental language disorder (linguistic errors); CRC cis rs6089584 0.606 rs2296082 chr20:60573983 A/G cg06108461 chr20:60628389 TAF4 -0.66 -11.39 -0.53 1.46e-25 Body mass index; CRC cis rs9322817 0.691 rs2486143 chr6:105308593 A/G cg02098413 chr6:105308735 HACE1 0.43 8.4 0.42 1.35e-15 Thyroid stimulating hormone; CRC trans rs2243480 0.803 rs34004500 chr7:65312178 A/T cg10756647 chr7:56101905 PSPH 0.73 7.72 0.39 1.46e-13 Diabetic kidney disease; CRC cis rs10256972 0.552 rs2960831 chr7:1201192 A/T cg27094323 chr7:1216898 NA -0.4 -6.61 -0.34 1.52e-10 Longevity;Endometriosis; CRC cis rs10971721 0.822 rs72727318 chr9:33901800 A/T cg13495928 chr9:33750294 PRSS3 0.56 5.97 0.31 6.15e-9 Body mass index; CRC cis rs4862750 0.872 rs4862748 chr4:187877388 C/T cg03647317 chr4:187891568 NA 0.47 7.76 0.39 1.06e-13 Lobe attachment (rater-scored or self-reported); CRC trans rs875971 0.660 rs2191268 chr7:66110224 C/T cg26591879 chr1:161736013 ATF6 -0.41 -6.36 -0.33 6.64e-10 Aortic root size; CRC cis rs4727027 0.901 rs4727018 chr7:148822247 G/C cg12479418 chr7:148823350 ZNF425;ZNF398 0.45 6.09 0.32 3.1e-9 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC trans rs205391 0.947 rs412951 chr16:28053011 A/C cg05061471 chr11:14994561 CALCA 0.52 6.02 0.31 4.65e-9 Obesity-related traits; CRC cis rs728616 0.614 rs35193855 chr10:81788495 C/A cg05935833 chr10:81318306 SFTPA2 -0.53 -7.12 -0.37 7.03e-12 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs883565 1.000 rs883565 chr3:39055317 C/T cg01426195 chr3:39028469 NA -0.42 -6.0 -0.31 5.19e-9 Handedness; CRC cis rs1129187 0.755 rs7760250 chr6:42929839 G/A cg21280719 chr6:42927975 GNMT -0.46 -10.42 -0.5 3.71e-22 Alzheimer's disease in APOE e4+ carriers; CRC cis rs9427116 0.502 rs12125166 chr1:154582129 A/G cg17218026 chr1:154582156 ADAR -0.65 -11.03 -0.52 2.86e-24 Blood protein levels; CRC cis rs875971 0.545 rs6969224 chr7:65834998 T/G cg18876405 chr7:65276391 NA 0.47 6.51 0.34 2.85e-10 Aortic root size; CRC cis rs72615157 0.634 rs74742883 chr7:99785765 T/G cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.57 6.78 0.35 5.45e-11 Lung function (FEV1/FVC); CRC cis rs2976388 0.609 rs2585140 chr8:143806896 A/G cg20041105 chr8:143859282 LYNX1 0.45 8.09 0.41 1.13e-14 Urinary tract infection frequency; CRC cis rs7772486 0.875 rs9399573 chr6:146403255 A/T cg23711669 chr6:146136114 FBXO30 0.63 10.72 0.51 3.38e-23 Lobe attachment (rater-scored or self-reported); CRC cis rs6502050 0.835 rs7213172 chr17:80085703 G/T cg19223190 chr17:80058835 NA -0.39 -6.24 -0.33 1.31e-9 Life satisfaction; CRC cis rs6543140 0.601 rs7558013 chr2:102992806 G/T cg09003973 chr2:102972529 NA 0.56 6.96 0.36 1.84e-11 Blood protein levels; CRC cis rs3741798 1.000 rs2160588 chr12:12487447 C/T cg08615371 chr12:12503544 MANSC1 1.07 10.25 0.49 1.39e-21 Cerebrospinal fluid biomarker levels; CRC cis rs2739330 0.760 rs1002286 chr22:24257337 A/G cg16132339 chr22:24313637 DDTL;DDT -0.65 -11.01 -0.52 3.32e-24 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs7927771 0.832 rs935914 chr11:47387599 C/T cg18512352 chr11:47633146 NA 0.33 6.53 0.34 2.48e-10 Subjective well-being; CRC cis rs10208940 0.841 rs7598760 chr2:68837054 A/G cg12452813 chr2:68675892 NA 0.48 6.02 0.31 4.69e-9 Urate levels in lean individuals; CRC trans rs6952808 0.693 rs10950413 chr7:1912988 A/G cg04565464 chr8:145669602 NFKBIL2 0.42 6.58 0.34 1.87e-10 Bipolar disorder and schizophrenia; CRC trans rs12599106 0.660 rs12919333 chr16:34991336 C/T cg11235426 chr6:292522 DUSP22 -0.66 -9.52 -0.46 3.81e-19 Menopause (age at onset); CRC cis rs1799949 0.930 rs33968979 chr17:41297992 G/T cg19454999 chr17:41278357 BRCA1;NBR2 0.55 8.65 0.43 2.28e-16 Menopause (age at onset); CRC cis rs12044355 0.929 rs12045248 chr1:231850748 A/G cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX 0.45 6.07 0.32 3.43e-9 Alzheimer's disease; CRC cis rs77633900 0.685 rs2469556 chr15:76650148 G/A cg21673338 chr15:77095150 SCAPER -0.74 -6.93 -0.36 2.29e-11 Non-glioblastoma glioma;Glioma; CRC cis rs1008375 0.932 rs12500947 chr4:17603424 C/T cg16339924 chr4:17578868 LAP3 0.52 6.75 0.35 6.86e-11 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs7044106 0.537 rs10818474 chr9:123489964 C/T cg09419670 chr9:123605666 PSMD5;LOC253039 0.79 12.1 0.56 3.79e-28 Hip circumference adjusted for BMI; CRC cis rs10504229 0.639 rs55687236 chr8:58105856 C/T cg02725872 chr8:58115012 NA -0.58 -7.95 -0.4 3.05e-14 Developmental language disorder (linguistic errors); CRC cis rs6460942 0.591 rs62448727 chr7:12332362 G/C cg06484146 chr7:12443880 VWDE -0.64 -6.83 -0.35 4.2e-11 Coronary artery disease; CRC cis rs9393692 0.905 rs9379843 chr6:26289435 A/G cg13736514 chr6:26305472 NA -0.63 -11.64 -0.54 1.85e-26 Educational attainment; CRC trans rs7618501 0.633 rs9866695 chr3:50069452 G/T cg21665057 chr3:196295764 WDR53;FBXO45 -0.61 -9.64 -0.47 1.59e-19 Intelligence (multi-trait analysis); CRC cis rs2836974 0.966 rs2836977 chr21:40666066 T/C cg06238570 chr21:40685208 BRWD1 0.79 11.03 0.52 2.79e-24 Cognitive function; CRC cis rs10504229 0.512 rs77289815 chr8:57995242 A/G cg24829409 chr8:58192753 C8orf71 -0.66 -7.19 -0.37 4.49e-12 Developmental language disorder (linguistic errors); CRC trans rs7613875 0.620 rs17657688 chr3:50033228 C/T cg21659725 chr3:3221576 CRBN -0.47 -7.06 -0.36 1.02e-11 Body mass index; CRC cis rs6502050 0.835 rs7405738 chr17:80084227 A/G cg25804541 chr17:80189381 SLC16A3 0.31 5.9 0.31 8.94e-9 Life satisfaction; CRC cis rs4664308 1.000 rs62175517 chr2:160911575 C/T cg03641300 chr2:160917029 PLA2R1 -0.75 -12.51 -0.57 1.18e-29 Idiopathic membranous nephropathy; CRC cis rs881375 0.678 rs9886724 chr9:123665019 A/G cg09419670 chr9:123605666 PSMD5;LOC253039 0.51 8.11 0.41 9.95e-15 Rheumatoid arthritis; CRC cis rs11971779 0.616 rs6967932 chr7:139022381 C/T cg07862535 chr7:139043722 LUC7L2 0.56 7.3 0.37 2.21e-12 Diisocyanate-induced asthma; CRC cis rs6460942 0.556 rs2287067 chr7:12370533 T/C cg06484146 chr7:12443880 VWDE -0.55 -7.49 -0.38 6.31e-13 Coronary artery disease; CRC cis rs2396545 0.634 rs35788385 chr11:570094 G/A cg01842473 chr11:617407 IRF7;MUPCDH -0.49 -5.67 -0.3 3.17e-8 Systemic lupus erythematosus and Systemic sclerosis; CRC cis rs4713118 0.786 rs200503 chr6:27785882 A/G cg21251018 chr6:28226885 NKAPL 0.44 5.95 0.31 6.99e-9 Parkinson's disease; CRC cis rs727563 0.562 rs5758458 chr22:42154132 G/A cg17554472 chr22:41940697 POLR3H 0.56 5.71 0.3 2.55e-8 Crohn's disease;Inflammatory bowel disease; CRC cis rs9926296 0.607 rs11076629 chr16:89875259 T/C cg27121462 chr16:89883253 FANCA 0.43 6.62 0.34 1.46e-10 Vitiligo; CRC cis rs9291683 0.588 rs12647117 chr4:10022059 T/C cg11266682 chr4:10021025 SLC2A9 0.53 11.36 0.53 1.81e-25 Bone mineral density; CRC cis rs13191362 1.000 rs13210756 chr6:163009030 T/A cg21926612 chr6:163149169 PACRG;PARK2 0.74 10.83 0.51 1.37e-23 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs9916302 0.904 rs12600751 chr17:37553651 G/C cg03013999 chr17:37608204 MED1 -0.42 -6.12 -0.32 2.72e-9 Glomerular filtration rate (creatinine); CRC cis rs720844 1.000 rs7590549 chr2:149333736 C/T cg09247360 chr2:149335327 NA 0.62 7.76 0.39 1.1e-13 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs3806843 1.000 rs10477033 chr5:140169603 G/C cg16607685 chr5:140181889 PCDHA2;PCDHA1;PCDHA3 -0.26 -6.02 -0.31 4.69e-9 Depressive symptoms (multi-trait analysis); CRC cis rs1878931 0.624 rs39728 chr16:3453076 A/T cg26668626 chr16:3451006 ZNF174;ZNF434 0.56 7.16 0.37 5.25e-12 Body mass index (adult); CRC cis rs6912958 1.000 rs9294380 chr6:88152667 G/A cg08069147 chr6:88032118 GJB7;C6orf162 -0.62 -9.51 -0.46 4.29e-19 Monocyte percentage of white cells; CRC trans rs9650657 0.504 rs7813802 chr8:11033976 C/T cg08975724 chr8:8085496 FLJ10661 0.4 6.15 0.32 2.24e-9 Neuroticism; CRC cis rs3857067 0.806 rs6532471 chr4:95108584 T/C cg11021082 chr4:95130006 SMARCAD1 -0.5 -7.82 -0.4 7.01e-14 QT interval; CRC cis rs11098499 0.588 rs6534149 chr4:120559292 T/G cg09307838 chr4:120376055 NA -0.59 -9.17 -0.45 5.42e-18 Corneal astigmatism; CRC cis rs2404602 0.684 rs28895952 chr15:76856776 A/G cg23625390 chr15:77176239 SCAPER -0.86 -14.04 -0.61 2.07e-35 Blood metabolite levels; CRC cis rs7771547 0.573 rs546272 chr6:36398562 G/A cg07856975 chr6:36356162 ETV7 0.39 5.64 0.3 3.61e-8 Platelet distribution width; CRC cis rs1448094 0.511 rs10506920 chr12:86165212 A/T cg00310523 chr12:86230176 RASSF9 0.38 6.1 0.32 3.01e-9 Major depressive disorder; CRC cis rs826838 0.967 rs10875979 chr12:39095149 G/A cg26384229 chr12:38710491 ALG10B 0.66 9.76 0.47 6.28e-20 Heart rate; CRC cis rs7312933 0.933 rs4534650 chr12:42444222 A/G cg11827402 chr12:42719852 PPHLN1;ZCRB1 0.6 7.63 0.39 2.57e-13 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CRC cis rs2153535 0.541 rs6932434 chr6:8467679 G/A cg21535247 chr6:8435926 SLC35B3 0.49 7.4 0.38 1.14e-12 Motion sickness; CRC cis rs8180040 0.966 rs13072802 chr3:47346415 G/C cg27129171 chr3:47204927 SETD2 0.55 8.75 0.43 1.1e-16 Colorectal cancer; CRC cis rs2976388 0.609 rs2585145 chr8:143799457 G/A cg05569086 chr8:143859399 LYNX1 0.38 6.58 0.34 1.88e-10 Urinary tract infection frequency; CRC cis rs12908161 1.000 rs35630683 chr15:85349231 T/C cg11189052 chr15:85197271 WDR73 0.57 7.98 0.4 2.41e-14 Schizophrenia; CRC cis rs6502050 0.740 rs4789748 chr17:80093061 A/C cg09264619 chr17:80180166 NA -0.37 -6.33 -0.33 8.13e-10 Life satisfaction; CRC cis rs7647973 1.000 rs940045 chr3:49449638 G/A cg07636037 chr3:49044803 WDR6 0.67 8.35 0.42 1.92e-15 Menarche (age at onset); CRC trans rs16846053 0.792 rs72875528 chr2:162533523 C/T cg18122310 chr12:50236657 BCDIN3D -0.74 -6.19 -0.32 1.81e-9 Blood osmolality (transformed sodium); CRC cis rs2832191 0.703 rs2853827 chr21:30443596 T/C cg08807101 chr21:30365312 RNF160 0.72 11.67 0.54 1.45e-26 Dental caries; CRC cis rs2276314 0.857 rs56230698 chr18:33628885 A/G cg05985134 chr18:33552581 C18orf21 0.5 6.92 0.36 2.34e-11 Endometriosis;Drug-induced torsades de pointes; CRC cis rs7647973 0.961 rs7638750 chr3:49452957 A/T cg07636037 chr3:49044803 WDR6 -0.64 -7.52 -0.38 5.43e-13 Menarche (age at onset); CRC cis rs1957429 0.808 rs1957436 chr14:65348207 T/G cg23373153 chr14:65346875 NA 0.79 8.25 0.41 3.9e-15 Pediatric areal bone mineral density (radius); CRC cis rs992157 0.965 rs13419763 chr2:219134950 C/T cg20019365 chr2:219134978 PNKD;AAMP 0.39 5.88 0.31 1.01e-8 Colorectal cancer; CRC cis rs72781680 1.000 rs72796357 chr2:24160131 A/G cg08917208 chr2:24149416 ATAD2B 0.93 9.42 0.46 8.51e-19 Lymphocyte counts; CRC cis rs780096 0.526 rs4803 chr2:27667297 A/G cg21248554 chr2:27665150 KRTCAP3 -0.34 -7.95 -0.4 3.07e-14 Total body bone mineral density; CRC cis rs644799 0.710 rs473852 chr11:95568757 C/A cg03916912 chr11:95522834 CEP57;FAM76B 0.87 16.15 0.67 1.26e-43 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs172166 0.516 rs1225710 chr6:28100640 C/T cg21251018 chr6:28226885 NKAPL -0.62 -10.96 -0.52 4.88e-24 Cardiac Troponin-T levels; CRC cis rs4862750 0.832 rs9995958 chr4:187901764 G/A cg10295955 chr4:187884368 NA -1.06 -28.72 -0.85 1.21e-91 Lobe attachment (rater-scored or self-reported); CRC cis rs4713118 0.955 rs9380012 chr6:27684654 A/G cg15786705 chr6:28176104 NA 0.48 6.42 0.33 4.89e-10 Parkinson's disease; CRC cis rs11583043 1.000 rs7541397 chr1:101322866 C/T cg00063077 chr1:101360652 SLC30A7;EXTL2 -0.5 -6.55 -0.34 2.27e-10 Ulcerative colitis;Inflammatory bowel disease; CRC cis rs6502050 0.865 rs56193110 chr17:80151501 A/G cg13198984 chr17:80129470 CCDC57 0.46 8.15 0.41 7.93e-15 Life satisfaction; CRC cis rs57221529 0.709 rs72706611 chr5:561146 C/A cg14541582 chr5:601475 NA -0.33 -6.42 -0.33 4.64e-10 Lung disease severity in cystic fibrosis; CRC cis rs1552244 0.572 rs6783705 chr3:10164783 A/G cg00166722 chr3:10149974 C3orf24 0.65 7.7 0.39 1.56e-13 Alzheimer's disease; CRC cis rs908922 0.676 rs7518654 chr1:152517845 C/G cg09873164 chr1:152488093 CRCT1 0.35 6.0 0.31 5.27e-9 Hair morphology; CRC cis rs10504229 0.775 rs55734109 chr8:58162322 G/A cg02290350 chr8:58132656 NA -0.49 -5.93 -0.31 7.66e-9 Developmental language disorder (linguistic errors); CRC cis rs17826219 0.706 rs8075357 chr17:29057197 A/C cg13385521 chr17:29058706 SUZ12P 0.7 7.84 0.4 6.34e-14 Body mass index; CRC trans rs7267979 1.000 rs884613 chr20:25288505 C/T cg17903999 chr18:56338584 MALT1 0.43 7.01 0.36 1.36e-11 Liver enzyme levels (alkaline phosphatase); CRC cis rs9435341 0.762 rs72697623 chr1:107554269 G/A cg03874509 chr1:107600012 PRMT6 0.43 5.79 0.3 1.64e-8 Facial morphology (factor 21, depth of nasal alae); CRC cis rs6540556 0.723 rs10863783 chr1:209889802 T/C cg05527609 chr1:210001259 C1orf107 -0.56 -5.88 -0.31 1.01e-8 Red blood cell count; CRC cis rs6582630 0.519 rs8189623 chr12:38351436 G/A cg26384229 chr12:38710491 ALG10B 0.69 9.79 0.48 4.92e-20 Drug-induced liver injury (flucloxacillin); CRC cis rs507506 0.771 rs929229 chr17:7105399 C/T cg13729891 chr17:7108468 DLG4 -0.47 -7.45 -0.38 8.41e-13 Adiponectin levels; CRC cis rs7586879 0.662 rs2384059 chr2:25100338 C/T cg04586622 chr2:25135609 ADCY3 -0.55 -10.17 -0.49 2.62e-21 Body mass index; CRC cis rs9786986 0.764 rs382584 chr1:235696155 A/C cg08848088 chr1:235714526 GNG4 0.49 5.76 0.3 1.89e-8 Body mass index; CRC cis rs13082711 0.834 rs2172297 chr3:27428423 C/T cg02860705 chr3:27208620 NA 0.59 8.39 0.42 1.41e-15 Systolic blood pressure;Diastolic blood pressure;Blood pressure; CRC trans rs11039798 0.528 rs10769559 chr11:49032446 T/C cg15704280 chr7:45808275 SEPT13 0.58 6.15 0.32 2.3e-9 Axial length; CRC cis rs1865760 0.929 rs2876693 chr6:25954434 C/G cg16482183 chr6:26056742 HIST1H1C 0.57 8.3 0.42 2.81e-15 Height; CRC cis rs6735179 0.549 rs56066419 chr2:1755649 G/A cg19300414 chr2:1746591 PXDN 0.33 5.8 0.3 1.55e-8 Response to antipsychotic treatment; CRC cis rs8078723 0.714 rs2241244 chr17:38153554 G/C cg17344932 chr17:38183730 MED24;SNORD124 0.49 8.02 0.4 1.88e-14 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); CRC cis rs6952808 0.929 rs11768206 chr7:1932151 T/G cg22963979 chr7:1858916 MAD1L1 -0.52 -7.63 -0.39 2.5e-13 Bipolar disorder and schizophrenia; CRC cis rs17023223 0.537 rs17023185 chr1:119610787 C/T cg05756136 chr1:119680316 WARS2 -0.5 -6.51 -0.34 2.87e-10 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for BMI in active individuals; CRC cis rs2115630 1.000 rs8037423 chr15:85355494 C/T cg09876464 chr15:85330779 ZNF592 0.47 8.09 0.41 1.14e-14 P wave terminal force; CRC cis rs10876993 0.928 rs1689587 chr12:58075398 A/G cg18357645 chr12:58087776 OS9 0.62 8.83 0.44 6.45e-17 Celiac disease or Rheumatoid arthritis; CRC cis rs3748682 1.000 rs3748682 chr1:38279987 C/T cg12658694 chr1:38397304 INPP5B -0.46 -6.09 -0.32 3.22e-9 Hypothyroidism; CRC cis rs2062225 1.000 rs1384793 chr2:111766127 C/A cg11729679 chr2:111877065 BCL2L11 -0.56 -5.62 -0.3 4.08e-8 Monocyte count; CRC cis rs10504229 0.683 rs6998040 chr8:58110155 G/T cg05313129 chr8:58192883 C8orf71 0.44 6.05 0.32 3.97e-9 Developmental language disorder (linguistic errors); CRC cis rs769267 0.965 rs2905425 chr19:19475717 G/C cg01262667 chr19:19385393 TM6SF2 -0.38 -6.21 -0.32 1.6e-9 Tonsillectomy; CRC cis rs17270561 0.609 rs7746609 chr6:25727996 C/T cg17691542 chr6:26056736 HIST1H1C -0.6 -8.12 -0.41 9.43e-15 Iron status biomarkers; CRC cis rs59043219 1 rs59043219 chr1:209970610 G/A cg04352962 chr1:209979756 IRF6 0.53 7.82 0.4 7.28e-14 Crohn's disease;Inflammatory bowel disease;Alzheimer's disease (APOE e4 interaction); CRC cis rs68170813 0.559 rs74387778 chr7:106963213 T/C cg02696742 chr7:106810147 HBP1 -0.57 -6.13 -0.32 2.49e-9 Coronary artery disease; CRC trans rs3733585 0.699 rs12498956 chr4:9950705 G/T cg26043149 chr18:55253948 FECH -0.45 -6.75 -0.35 6.76e-11 Cleft plate (environmental tobacco smoke interaction); CRC cis rs4604732 0.527 rs7539082 chr1:247627260 T/C cg12754571 chr1:247694271 LOC148824;OR2C3 0.41 5.77 0.3 1.87e-8 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CRC cis rs35146811 0.735 rs1727140 chr7:99815399 T/A cg13334819 chr7:99746414 C7orf59 0.52 6.78 0.35 5.48e-11 Coronary artery disease; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg04742047 chr19:14544036 PKN1 0.36 6.07 0.32 3.51e-9 Liver disease severity in Alagille syndrome; CRC cis rs2070677 0.935 rs11101869 chr10:135400631 C/T cg20169779 chr10:135381914 SYCE1 -0.94 -14.88 -0.63 1.2e-38 Gout; CRC cis rs1552244 1.000 rs6772315 chr3:10113644 G/A cg18598329 chr3:10140678 FANCD2;C3orf24 -0.86 -11.53 -0.54 4.46e-26 Alzheimer's disease; CRC cis rs4713118 0.955 rs9380011 chr6:27683924 A/G cg02683197 chr6:28174875 NA 0.57 7.53 0.38 5.05e-13 Parkinson's disease; CRC cis rs6700896 0.931 rs1938498 chr1:66098653 T/C cg04111102 chr1:66153794 NA 0.32 5.67 0.3 3.06e-8 C-reactive protein;Mean corpuscular volume;Mean corpuscular hemoglobin; CRC cis rs10504229 0.683 rs16921937 chr8:58145010 A/G cg02725872 chr8:58115012 NA -0.64 -11.26 -0.53 4.38e-25 Developmental language disorder (linguistic errors); CRC cis rs904251 0.861 rs2776877 chr6:37487135 G/A cg01843034 chr6:37503916 NA -0.48 -8.8 -0.44 7.73e-17 Cognitive performance; CRC cis rs17023223 0.537 rs3934789 chr1:119683063 G/A cg05756136 chr1:119680316 WARS2 -0.53 -7.24 -0.37 3.29e-12 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for BMI in active individuals; CRC cis rs11148252 0.538 rs9535879 chr13:52704624 T/A cg02158880 chr13:53174818 NA 0.41 5.84 0.31 1.27e-8 Lewy body disease; CRC cis rs853679 0.882 rs9461432 chr6:28086883 T/C cg15786705 chr6:28176104 NA 0.7 5.78 0.3 1.74e-8 Depression; CRC cis rs2239547 0.522 rs7652131 chr3:52997154 C/T cg10802521 chr3:52805072 NEK4 -0.45 -6.15 -0.32 2.28e-9 Schizophrenia; CRC cis rs5769765 0.862 rs9616386 chr22:50313179 G/A cg22709217 chr22:50311962 ALG12;CRELD2 -1.12 -18.26 -0.71 6.49e-52 Schizophrenia; CRC trans rs4332037 0.624 rs73046339 chr7:1889300 G/A cg11693508 chr17:37793320 STARD3 0.64 8.37 0.42 1.65e-15 Bipolar disorder; CRC cis rs951366 0.789 rs823121 chr1:205724302 A/G cg11965913 chr1:205819406 PM20D1 -0.81 -13.1 -0.59 7.58e-32 Menarche (age at onset); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg24833071 chr7:75115655 POM121C 0.41 6.77 0.35 5.76e-11 Liver disease severity in Alagille syndrome; CRC cis rs13108904 0.901 rs13124847 chr4:1278206 A/G cg19318889 chr4:1322082 MAEA 0.4 5.74 0.3 2.13e-8 Obesity-related traits; CRC cis rs9733 0.596 rs7538493 chr1:150655421 T/C cg15448220 chr1:150897856 SETDB1 0.45 6.43 0.33 4.42e-10 Tonsillectomy; CRC cis rs1448094 0.791 rs7300340 chr12:86329867 G/T cg00310523 chr12:86230176 RASSF9 0.43 7.26 0.37 2.88e-12 Major depressive disorder; CRC trans rs4276421 0.806 rs2337412 chr5:45483512 G/T cg04793272 chr11:119020941 ABCG4 -0.39 -6.46 -0.34 3.86e-10 P wave duration; CRC trans rs4263408 0.934 rs9683743 chr4:39703194 A/C cg07219710 chr6:74230925 EEF1A1 -0.44 -6.37 -0.33 6.34e-10 Plasma amyloid beta peptide concentrations (ABx-40); CRC cis rs887797 0.576 rs9914573 chr17:64591389 A/G cg27019712 chr17:64599478 PRKCA -0.37 -5.65 -0.3 3.51e-8 Possible neuropathic pain in post total joint replacement surgery for osteoarthritis; CRC cis rs9811920 0.809 rs902159 chr3:99747445 A/G cg07805332 chr3:99536008 MIR548G;C3orf26 -0.39 -6.05 -0.32 3.85e-9 Axial length; CRC cis rs1799949 0.930 rs35292991 chr17:41334016 C/A cg23758822 chr17:41437982 NA 0.82 14.03 0.61 2.33e-35 Menopause (age at onset); CRC cis rs9322193 0.962 rs9397357 chr6:150133601 G/A cg13206674 chr6:150067644 NUP43 0.54 7.66 0.39 2.09e-13 Lung cancer; CRC cis rs8177253 1.000 rs8177253 chr3:133480192 A/G cg08048268 chr3:133502702 NA 0.37 7.09 0.36 8.03e-12 Iron status biomarkers; CRC cis rs7666738 0.800 rs13106995 chr4:99028790 A/T cg05340658 chr4:99064831 C4orf37 0.61 9.42 0.46 8.23e-19 Colonoscopy-negative controls vs population controls; CRC cis rs561341 1.000 rs757009 chr17:30243937 A/G cg00745463 chr17:30367425 LRRC37B -0.55 -6.76 -0.35 6.19e-11 Hip circumference adjusted for BMI; CRC cis rs9583531 0.600 rs1441043 chr13:111367650 A/G cg24331049 chr13:111365604 ING1 0.6 8.13 0.41 8.89e-15 Coronary artery disease; CRC trans rs944990 0.595 rs10123378 chr9:96375217 C/T cg07808590 chr11:64137524 RPS6KA4 0.41 6.07 0.32 3.51e-9 Body mass index; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg08089702 chr22:21822289 NA 0.49 6.34 0.33 7.36e-10 Thyroid stimulating hormone; CRC cis rs17209837 0.646 rs10452935 chr7:87094247 A/T cg00919237 chr7:87102261 ABCB4 -0.54 -7.09 -0.36 8.37e-12 Gallbladder cancer; CRC cis rs35306767 0.855 rs56222464 chr10:867535 C/G cg20503657 chr10:835505 NA 1.23 15.05 0.64 2.68e-39 Eosinophil percentage of granulocytes; CRC trans rs9903692 0.954 rs2051821 chr17:46143515 T/C cg13910583 chr8:56987998 RPS20 -0.45 -6.04 -0.32 4.2e-9 Pulse pressure; CRC cis rs763121 0.853 rs3761454 chr22:39066820 C/T cg06544989 chr22:39130855 UNC84B 0.46 7.15 0.37 5.81e-12 Menopause (age at onset); CRC cis rs2032447 0.670 rs198845 chr6:26107790 A/C cg26028573 chr6:26043587 HIST1H2BB 0.39 5.61 0.3 4.29e-8 Intelligence (multi-trait analysis); CRC cis rs514406 0.861 rs72637996 chr1:53249618 A/T cg24675658 chr1:53192096 ZYG11B 0.6 9.48 0.46 5.13e-19 Monocyte count; CRC cis rs10752881 1.000 rs10752881 chr1:182973491 A/G ch.1.3577855R chr1:183094577 LAMC1 0.87 15.23 0.64 4.96e-40 Colorectal cancer; CRC cis rs6541297 1.000 rs6665260 chr1:230279067 G/T cg05784532 chr1:230284198 GALNT2 0.44 6.19 0.32 1.75e-9 Coronary artery disease; CRC cis rs9287719 0.934 rs10181806 chr2:10741141 A/G cg00105475 chr2:10696890 NA 0.45 7.3 0.37 2.19e-12 Prostate cancer; CRC cis rs17401966 0.838 rs946503 chr1:10308631 C/G cg19773385 chr1:10388646 KIF1B 0.63 10.13 0.49 3.73e-21 Hepatocellular carcinoma; CRC cis rs7909074 1.000 rs7909074 chr10:45395839 G/A cg05187965 chr10:45406764 TMEM72 -0.38 -8.81 -0.44 7.14e-17 Mean corpuscular volume; CRC cis rs1707322 0.752 rs8179402 chr1:46142466 C/A cg06784218 chr1:46089804 CCDC17 0.66 12.35 0.56 4.77e-29 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs798554 0.797 rs1182174 chr7:2875420 G/A cg17321639 chr7:2759063 NA -0.53 -7.09 -0.36 8.11e-12 Height; CRC cis rs7666738 1.000 rs13106934 chr4:99028685 C/T cg17366294 chr4:99064904 C4orf37 0.45 7.24 0.37 3.17e-12 Colonoscopy-negative controls vs population controls; CRC cis rs7618915 0.547 rs11130313 chr3:52676190 A/C cg15147215 chr3:52552868 STAB1 -0.62 -10.24 -0.49 1.48e-21 Bipolar disorder; CRC trans rs17780086 0.529 rs7406406 chr17:30220153 T/G cg20587970 chr11:113659929 NA -0.54 -7.18 -0.37 4.7e-12 Height; CRC cis rs473651 0.935 rs541013 chr2:239336492 G/A cg21699342 chr2:239360505 ASB1 0.58 10.5 0.5 1.94e-22 Multiple system atrophy; CRC cis rs780096 0.546 rs2293572 chr2:27728777 C/G cg21248554 chr2:27665150 KRTCAP3 0.31 6.97 0.36 1.7e-11 Total body bone mineral density; CRC cis rs1341267 0.529 rs6492721 chr13:95258944 A/G cg18412871 chr13:95254051 GPR180 -0.54 -7.53 -0.38 4.94e-13 Triglyceride levels; CRC cis rs2976388 0.578 rs3758081 chr8:143824373 A/G cg22687807 chr8:143858763 LYNX1 -0.46 -7.14 -0.37 6.2e-12 Urinary tract infection frequency; CRC cis rs644799 1.000 rs593665 chr11:95574302 A/G cg25622487 chr11:95524042 FAM76B;CEP57 0.76 11.98 0.55 1.12e-27 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs9549260 0.651 rs57735994 chr13:41226561 C/G cg21288729 chr13:41239152 FOXO1 0.49 7.63 0.39 2.54e-13 Red blood cell count; CRC cis rs7246760 1.000 rs113915533 chr19:9881379 A/C cg16876255 chr19:9731953 ZNF561 0.69 5.71 0.3 2.49e-8 Pursuit maintenance gain; CRC cis rs9296404 1 rs9296404 chr6:42925803 T/C cg03790207 chr6:42947109 PEX6 -0.52 -7.68 -0.39 1.82e-13 Plasma homocysteine levels (post-methionine load test); CRC cis rs889398 0.617 rs55887947 chr16:69893343 G/A cg00738113 chr16:70207722 CLEC18C -0.35 -6.21 -0.32 1.58e-9 Body mass index; CRC cis rs4332037 0.539 rs57148375 chr7:2025001 G/C cg23422044 chr7:1970798 MAD1L1 -0.61 -7.53 -0.38 4.86e-13 Bipolar disorder; CRC cis rs9322193 0.884 rs10872647 chr6:150079823 T/C cg00933542 chr6:150070202 PCMT1 0.31 5.98 0.31 5.84e-9 Lung cancer; CRC cis rs7552404 0.920 rs2788654 chr1:76219569 C/T cg10523679 chr1:76189770 ACADM 0.77 11.71 0.54 1.07e-26 Blood metabolite levels;Acylcarnitine levels; CRC trans rs7615952 0.546 rs4428131 chr3:125346479 C/T cg00769240 chr8:12517080 NA -0.66 -7.45 -0.38 8.21e-13 Blood pressure (smoking interaction); CRC cis rs12497850 0.863 rs4858799 chr3:48728204 G/C cg07636037 chr3:49044803 WDR6 0.93 16.06 0.66 3.02e-43 Parkinson's disease; CRC cis rs6502050 0.799 rs4789667 chr17:80162143 C/T cg19223190 chr17:80058835 NA 0.41 6.67 0.35 1.09e-10 Life satisfaction; CRC cis rs6681460 1.000 rs1329978 chr1:67116231 C/T cg02459107 chr1:67143332 SGIP1 0.46 7.94 0.4 3.15e-14 Presence of antiphospholipid antibodies; CRC cis rs10986311 0.722 rs6478660 chr9:127133920 A/T cg14243010 chr9:127117328 LOC100129034;PSMB7 0.43 6.49 0.34 3.22e-10 Vitiligo; CRC trans rs61101201 0.962 rs10835790 chr11:31610022 C/T cg14840727 chr4:7783969 AFAP1 -0.52 -6.1 -0.32 3.05e-9 Optic disc area; CRC cis rs11249608 0.548 rs11960161 chr5:178453837 A/G cg01312482 chr5:178451176 ZNF879 -0.36 -5.99 -0.31 5.53e-9 Pubertal anthropometrics; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg27180563 chr19:13056485 RAD23A 0.43 6.17 0.32 1.99e-9 Anxiety disorder; CRC cis rs4713118 0.568 rs9468213 chr6:27706180 G/A cg08798685 chr6:27730294 NA -0.39 -5.92 -0.31 8.2e-9 Parkinson's disease; CRC cis rs7552404 0.960 rs61797339 chr1:76189946 G/T cg03433033 chr1:76189801 ACADM 0.81 11.34 0.53 2.26e-25 Blood metabolite levels;Acylcarnitine levels; CRC cis rs1891275 0.515 rs7092745 chr10:93483820 C/T cg07889827 chr10:93443413 NA -0.39 -6.5 -0.34 3.01e-10 Intelligence (multi-trait analysis); CRC cis rs2289583 0.597 rs12148708 chr15:75384397 G/A cg14664628 chr15:75095509 CSK 0.45 6.27 0.33 1.11e-9 Systemic lupus erythematosus; CRC cis rs3858526 0.920 rs11039698 chr11:5950907 C/T cg05234568 chr11:5960015 NA -0.58 -8.0 -0.4 2.08e-14 DNA methylation (variation); CRC cis rs2228479 0.850 rs17226428 chr16:89842884 T/A cg06656553 chr16:89960601 TCF25 -0.71 -5.96 -0.31 6.42e-9 Skin colour saturation; CRC cis rs853679 0.517 rs4713143 chr6:28106759 A/C cg06470822 chr6:28175283 NA 1.0 13.33 0.59 1.06e-32 Depression; CRC cis rs17270561 0.609 rs1317817 chr6:25765377 G/A cg17691542 chr6:26056736 HIST1H1C 0.65 8.23 0.41 4.38e-15 Iron status biomarkers; CRC cis rs875971 1.000 rs1167411 chr7:65539264 C/G cg11764359 chr7:65958608 NA -0.6 -9.48 -0.46 5.13e-19 Aortic root size; CRC cis rs1799949 1.000 rs8176296 chr17:41203591 T/C cg23758822 chr17:41437982 NA 0.8 13.69 0.6 4.46e-34 Menopause (age at onset); CRC cis rs875971 0.862 rs6944374 chr7:65686929 C/G cg18252515 chr7:66147081 NA 0.42 5.9 0.31 9.22e-9 Aortic root size; CRC cis rs875971 0.825 rs59466412 chr7:65565358 A/G cg11764359 chr7:65958608 NA -0.58 -8.83 -0.44 6.38e-17 Aortic root size; CRC cis rs1448094 0.817 rs11117115 chr12:86331021 A/G cg00310523 chr12:86230176 RASSF9 0.43 7.26 0.37 2.88e-12 Major depressive disorder; CRC cis rs10751667 0.643 rs7396623 chr11:934104 G/A cg23136738 chr11:925521 AP2A2 -0.42 -6.93 -0.36 2.19e-11 Alzheimer's disease (late onset); CRC cis rs4746818 0.793 rs2008541 chr10:70860599 A/G cg11621586 chr10:70884670 VPS26A 0.66 6.03 0.32 4.3e-9 Left atrial antero-posterior diameter; CRC cis rs7487075 0.578 rs4768713 chr12:46814047 A/G cg22049899 chr12:47219821 SLC38A4 0.31 5.67 0.3 3.17e-8 Itch intensity from mosquito bite; CRC cis rs2739330 0.731 rs2000468 chr22:24241611 G/T cg11060661 chr22:24314208 DDT;DDTL 0.45 7.78 0.39 9.7e-14 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs9527 0.590 rs12414232 chr10:104914491 A/T cg15744005 chr10:104629667 AS3MT -0.31 -6.1 -0.32 3.03e-9 Arsenic metabolism; CRC trans rs7395662 0.833 rs1963073 chr11:48975094 T/A cg21153622 chr11:89784906 NA -0.48 -7.6 -0.39 3.06e-13 HDL cholesterol; CRC cis rs4889855 0.530 rs12603265 chr17:78618637 A/G cg16591659 chr17:78472290 NA -0.43 -6.29 -0.33 1.01e-9 Fractional excretion of uric acid; CRC cis rs17092148 0.652 rs7269526 chr20:33053293 G/C cg08999081 chr20:33150536 PIGU -0.45 -5.68 -0.3 3.02e-8 Neuroticism; CRC cis rs2836974 0.602 rs2037925 chr21:40699931 C/T cg11890956 chr21:40555474 PSMG1 -0.83 -13.54 -0.6 1.68e-33 Cognitive function; CRC cis rs568617 1.000 rs568617 chr11:65653242 C/T cg19792802 chr11:65647270 CTSW 0.5 7.55 0.38 4.23e-13 Crohn's disease; CRC cis rs66573146 0.808 rs55942328 chr4:6990960 T/G cg00086871 chr4:6988644 TBC1D14 0.95 7.98 0.4 2.46e-14 Granulocyte percentage of myeloid white cells; CRC cis rs2153535 0.580 rs3938660 chr6:8443335 G/A cg07606381 chr6:8435919 SLC35B3 0.68 10.86 0.51 1.08e-23 Motion sickness; CRC trans rs2303319 0.504 rs56009150 chr2:162598582 T/C cg10498984 chr16:28874827 SH2B1 -0.73 -6.25 -0.33 1.3e-9 Cognitive function; CRC cis rs853679 0.517 rs9380059 chr6:28132358 A/C cg15786705 chr6:28176104 NA 0.78 9.83 0.48 3.57e-20 Depression; CRC cis rs8063761 0.689 rs4785763 chr16:90066936 G/T cg25193494 chr16:90016004 DEF8 -0.43 -6.16 -0.32 2.14e-9 Squamous cell carcinoma; CRC cis rs3785574 0.962 rs2955235 chr17:61966950 A/C cg22520471 chr17:61851767 DDX42;CCDC47 0.43 5.89 0.31 9.33e-9 Height; CRC cis rs7647973 0.710 rs7629322 chr3:49621994 C/T cg13072238 chr3:49761600 GMPPB -0.51 -5.78 -0.3 1.74e-8 Menarche (age at onset); CRC cis rs9611565 0.512 rs4820446 chr22:42215684 C/T cg03806693 chr22:41940476 POLR3H -1.08 -12.78 -0.58 1.21e-30 Vitiligo; CRC trans rs507506 0.771 rs929229 chr17:7105399 C/T cg15655154 chr3:113604241 GRAMD1C 0.59 9.74 0.47 7.57e-20 Adiponectin levels; CRC cis rs77972916 0.536 rs62137421 chr2:43594091 C/T cg06169590 chr2:43455088 ZFP36L2;LOC100129726 -0.52 -5.85 -0.31 1.16e-8 Granulocyte percentage of myeloid white cells; CRC cis rs1448094 0.621 rs10863089 chr12:86279699 C/T cg02569458 chr12:86230093 RASSF9 0.38 6.29 0.33 9.9e-10 Major depressive disorder; CRC cis rs10924970 0.967 rs6680443 chr1:235480067 A/G cg26050004 chr1:235667680 B3GALNT2 0.41 6.08 0.32 3.36e-9 Asthma; CRC cis rs6951245 0.638 rs74976697 chr7:1160505 C/T cg22907277 chr7:1156413 C7orf50 0.77 8.84 0.44 5.74e-17 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs2836974 0.583 rs2410124 chr21:40704760 C/G cg17971929 chr21:40555470 PSMG1 -0.65 -9.61 -0.47 1.91e-19 Cognitive function; CRC cis rs9905704 0.846 rs372648 chr17:56736785 A/C cg12560992 chr17:57184187 TRIM37 0.57 8.29 0.42 2.9e-15 Testicular germ cell tumor; CRC cis rs8031584 0.736 rs11635775 chr15:31160640 A/G cg14829155 chr15:31115871 NA -0.66 -9.97 -0.48 1.23e-20 Huntington's disease progression; CRC cis rs11229555 0.645 rs7929028 chr11:58188258 C/T cg15696309 chr11:58395628 NA -0.82 -10.31 -0.49 8.59e-22 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; CRC cis rs59698941 0.943 rs12515752 chr5:132312960 C/G cg14825688 chr5:132208181 LEAP2 -0.49 -5.72 -0.3 2.37e-8 Apolipoprotein A-IV levels; CRC cis rs2072499 0.778 rs2842868 chr1:156196407 A/C cg25208724 chr1:156163844 SLC25A44 0.96 15.0 0.64 3.97e-39 Testicular germ cell tumor; CRC cis rs1862618 0.853 rs2548665 chr5:56131805 T/A cg24531977 chr5:56204891 C5orf35 -0.81 -10.94 -0.52 5.99e-24 Initial pursuit acceleration; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg03277652 chr8:142011117 PTK2 0.47 7.68 0.39 1.87e-13 Liver disease severity in Alagille syndrome; CRC cis rs1707322 0.650 rs4660879 chr1:46105401 C/A cg03146154 chr1:46216737 IPP 0.66 9.69 0.47 1.07e-19 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs12325245 0.536 rs71389028 chr16:58663260 G/A cg26666090 chr16:58549219 SETD6 0.94 6.49 0.34 3.19e-10 Schizophrenia; CRC trans rs2303319 0.504 rs35304298 chr2:162617185 G/T cg22677401 chr17:46026860 NA -0.67 -6.09 -0.32 3.14e-9 Cognitive function; CRC cis rs1580019 0.523 rs9791770 chr7:32582252 C/A cg07520158 chr7:32535189 LSM5;AVL9 0.53 7.76 0.39 1.07e-13 Cognitive ability; CRC cis rs7264396 0.561 rs6058387 chr20:34568092 G/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.58 -8.5 -0.42 6.5e-16 Total cholesterol levels; CRC cis rs4664293 0.967 rs13020365 chr2:160476404 G/A cg08347373 chr2:160653686 CD302 -0.45 -7.25 -0.37 2.95e-12 Monocyte percentage of white cells; CRC cis rs4363385 0.818 rs10888525 chr1:153000215 G/A cg25856811 chr1:152973957 SPRR3 -0.25 -6.8 -0.35 5.09e-11 Inflammatory skin disease; CRC cis rs9372498 0.536 rs9489399 chr6:118767147 C/A cg07617317 chr6:118971624 C6orf204 0.52 6.48 0.34 3.43e-10 Diastolic blood pressure; CRC cis rs1003719 0.788 rs2835602 chr21:38469069 G/C cg10648535 chr21:38446584 PIGP;TTC3 0.51 7.19 0.37 4.48e-12 Eye color traits; CRC cis rs6429082 0.818 rs704722 chr1:235669988 G/A cg26050004 chr1:235667680 B3GALNT2 0.58 7.8 0.4 8.03e-14 Adiposity; CRC cis rs4332037 0.522 rs4721098 chr7:1881527 G/C cg23422044 chr7:1970798 MAD1L1 0.49 6.32 0.33 8.72e-10 Bipolar disorder; CRC cis rs561341 1.000 rs7216102 chr17:30259450 A/G cg00745463 chr17:30367425 LRRC37B -0.6 -7.57 -0.39 3.83e-13 Hip circumference adjusted for BMI; CRC cis rs990171 1.000 rs6737668 chr2:103093081 C/T cg03938978 chr2:103052716 IL18RAP 0.45 5.71 0.3 2.5e-8 Lymphocyte counts; CRC cis rs2062225 1.000 rs3789093 chr2:111750549 C/T cg11729679 chr2:111877065 BCL2L11 -0.58 -5.63 -0.3 3.81e-8 Monocyte count; CRC cis rs9462027 0.628 rs9462019 chr6:34748730 C/T cg07306190 chr6:34760872 UHRF1BP1 -0.35 -6.23 -0.32 1.41e-9 Systemic lupus erythematosus; CRC cis rs1865760 0.613 rs9358894 chr6:25923315 C/T cg03264133 chr6:25882463 NA -0.48 -7.2 -0.37 4.11e-12 Height; CRC cis rs2832191 1.000 rs2832191 chr21:30489300 A/C cg08807101 chr21:30365312 RNF160 -0.61 -9.75 -0.47 6.61e-20 Dental caries; CRC cis rs4319547 0.656 rs3817011 chr12:122819566 C/T cg23029597 chr12:123009494 RSRC2 -0.49 -6.32 -0.33 8.28e-10 Body mass index; CRC cis rs7107174 1.000 rs7116611 chr11:78030046 A/G cg02023728 chr11:77925099 USP35 0.51 7.34 0.38 1.67e-12 Testicular germ cell tumor; CRC cis rs17092148 0.616 rs1122174 chr20:33110846 T/C cg08999081 chr20:33150536 PIGU 0.46 5.65 0.3 3.45e-8 Neuroticism; CRC cis rs270601 0.683 rs81598 chr5:131587960 C/G cg27615366 chr5:131592974 PDLIM4 0.33 5.86 0.31 1.1e-8 Acylcarnitine levels; CRC cis rs7692995 1.000 rs13144742 chr4:17974181 A/G cg08925142 chr4:18023851 LCORL -0.5 -5.65 -0.3 3.39e-8 Height; CRC trans rs11148252 0.538 rs9535885 chr13:52726524 A/G cg18335740 chr13:41363409 SLC25A15 0.54 8.15 0.41 7.54e-15 Lewy body disease; CRC cis rs12134245 0.776 rs6688261 chr1:91987034 C/T cg02896835 chr1:92012615 NA -0.69 -13.47 -0.6 2.94e-33 Breast cancer; CRC cis rs1555322 0.530 rs2275275 chr20:33872311 G/C cg03689076 chr20:33865952 NA 0.47 6.64 0.34 1.27e-10 Attention deficit hyperactivity disorder; CRC trans rs7615952 0.546 rs2922171 chr3:125343193 C/T cg02007433 chr3:129722099 NA -0.51 -6.26 -0.33 1.19e-9 Blood pressure (smoking interaction); CRC cis rs546131 0.928 rs552868 chr11:34830694 G/A cg06937548 chr11:34938143 PDHX;APIP 0.41 6.19 0.32 1.76e-9 Lung disease severity in cystic fibrosis; CRC cis rs7944584 0.511 rs10838731 chr11:47607135 C/T cg20307385 chr11:47447363 PSMC3 0.85 12.58 0.57 7e-30 Fasting blood glucose;Fasting blood glucose (BMI interaction); CRC cis rs8044868 0.530 rs8060770 chr16:72155694 C/A cg06172871 chr16:72088244 HP 0.41 6.06 0.32 3.76e-9 Body mass index (change over time) in cancer or chronic obstructive pulmonary disease;Body mass index (change over time) in cancer; CRC cis rs4478858 0.684 rs7519766 chr1:31735512 C/A cg00250761 chr1:31883323 NA -0.43 -8.5 -0.42 6.71e-16 Alcohol dependence; CRC cis rs1395 0.778 rs62128747 chr2:27412605 T/C cg14242246 chr2:27434262 C2orf28;SLC5A6 0.4 7.33 0.37 1.74e-12 Blood metabolite levels; CRC trans rs12478296 0.901 rs67423532 chr2:243004719 A/G cg18288967 chr1:45987694 PRDX1 0.68 7.72 0.39 1.37e-13 Obesity-related traits; CRC cis rs12893668 0.644 rs12890820 chr14:104034849 T/C cg08213375 chr14:104286397 PPP1R13B 0.37 6.06 0.32 3.81e-9 Reticulocyte count; CRC cis rs9325144 0.555 rs1843867 chr12:38703855 A/G cg26384229 chr12:38710491 ALG10B -0.54 -8.14 -0.41 8.44e-15 Morning vs. evening chronotype; CRC cis rs2304069 0.507 rs13167061 chr5:149388624 T/G cg12661370 chr5:149340060 SLC26A2 0.43 6.19 0.32 1.8e-9 HIV-1 control; CRC cis rs13108904 0.557 rs1680030 chr4:1245500 A/T cg20887711 chr4:1340912 KIAA1530 -0.63 -8.7 -0.43 1.63e-16 Obesity-related traits; CRC cis rs968567 0.705 rs174575 chr11:61602003 C/G cg00603274 chr11:61596626 FADS2 -0.5 -6.87 -0.35 3.17e-11 Blood metabolite levels;Rheumatoid arthritis;Vitiligo;Glycerophospholipid levels; CRC cis rs2949837 0.655 rs11977526 chr7:46008110 G/A cg10677697 chr7:45961126 IGFBP3 0.41 6.88 0.35 2.98e-11 Sitting height ratio; CRC trans rs1455244 0.700 rs7229302 chr18:11508904 G/T cg13980533 chr15:32322829 CHRNA7 0.4 6.26 0.33 1.18e-9 Schizophrenia; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg18274279 chr7:73153629 ABHD11 0.42 5.99 0.31 5.39e-9 Anxiety disorder; CRC cis rs3736485 0.816 rs6493503 chr15:51821041 C/G cg08986416 chr15:51914746 DMXL2 -0.49 -7.06 -0.36 9.93e-12 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs7618915 0.501 rs2079929 chr3:52765646 C/T cg18404041 chr3:52824283 ITIH1 -0.41 -8.4 -0.42 1.36e-15 Bipolar disorder; CRC cis rs1552244 0.938 rs56274701 chr3:10167790 G/A cg18598329 chr3:10140678 FANCD2;C3orf24 -0.85 -11.33 -0.53 2.36e-25 Alzheimer's disease; CRC cis rs12413816 0.517 rs4750400 chr10:13765923 A/G cg16485048 chr10:13749193 FRMD4A 0.46 7.76 0.39 1.05e-13 Red cell distribution width; CRC cis rs539514 0.664 rs1323712 chr13:76300085 C/G cg04757411 chr13:76259545 LMO7 -0.36 -6.06 -0.32 3.81e-9 Type 1 diabetes; CRC cis rs9322193 0.923 rs55993747 chr6:149943152 A/G cg07701084 chr6:150067640 NUP43 0.59 8.79 0.44 8.6e-17 Lung cancer; CRC cis rs11785400 0.793 rs9297969 chr8:143723237 A/G cg10596483 chr8:143751796 JRK 0.47 6.37 0.33 6.37e-10 Schizophrenia; CRC trans rs10504229 1.000 rs67384205 chr8:58180348 C/G cg04077850 chr5:125800366 GRAMD3 0.37 6.27 0.33 1.15e-9 Developmental language disorder (linguistic errors); CRC cis rs629535 0.783 rs538832 chr8:70033817 A/G cg26132723 chr8:70041827 NA 0.35 5.72 0.3 2.41e-8 Dupuytren's disease; CRC cis rs62064224 0.614 rs728718 chr17:30708960 T/G cg09324608 chr17:30823087 MYO1D 0.33 5.63 0.3 3.89e-8 Schizophrenia; CRC cis rs73001065 0.901 rs739846 chr19:19419071 G/A cg03709012 chr19:19516395 GATAD2A 0.92 6.29 0.33 1.02e-9 LDL cholesterol; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg22608147 chr4:77069698 NUP54 0.51 7.66 0.39 2.09e-13 Intelligence (multi-trait analysis); CRC trans rs3733585 0.699 rs60045583 chr4:9971950 G/A cg26043149 chr18:55253948 FECH -0.47 -7.14 -0.37 6.03e-12 Cleft plate (environmental tobacco smoke interaction); CRC cis rs2180341 0.576 rs2057224 chr6:127624414 C/G cg27446573 chr6:127587934 RNF146 0.63 9.23 0.45 3.3e-18 Breast cancer; CRC cis rs77972916 0.519 rs13411327 chr2:43515483 G/C cg06169590 chr2:43455088 ZFP36L2;LOC100129726 -0.61 -5.97 -0.31 6.02e-9 Granulocyte percentage of myeloid white cells; CRC cis rs17443541 0.507 rs4675698 chr2:200451350 T/C cg03741458 chr2:200468445 NA -0.38 -5.95 -0.31 6.72e-9 Intelligence (multi-trait analysis); CRC cis rs780096 0.565 rs13022659 chr2:27743630 C/T cg21248554 chr2:27665150 KRTCAP3 -0.3 -6.48 -0.34 3.4e-10 Total body bone mineral density; CRC cis rs6089584 0.821 rs2273990 chr20:60579149 G/T cg13770153 chr20:60521292 NA -0.56 -9.38 -0.46 1.12e-18 Body mass index; CRC cis rs1218582 0.772 rs10796934 chr1:154849479 C/G cg06221963 chr1:154839813 KCNN3 -0.79 -16.33 -0.67 2.65e-44 Prostate cancer; CRC cis rs9926296 0.508 rs1558184 chr16:89842374 T/G cg03388025 chr16:89894329 SPIRE2 0.45 9.12 0.45 7.46e-18 Vitiligo; CRC cis rs4919694 1.000 rs76255497 chr10:104651955 T/C cg04362960 chr10:104952993 NT5C2 1.08 9.82 0.48 3.92e-20 Arsenic metabolism; CRC cis rs6686643 0.762 rs6672982 chr1:165612815 T/A cg19407955 chr1:165599744 MGST3 -0.52 -6.62 -0.34 1.49e-10 Total ventricular volume; CRC cis rs62064224 0.589 rs2344976 chr17:30685935 T/C cg12855166 chr17:30846586 MYO1D -0.37 -6.02 -0.32 4.57e-9 Schizophrenia; CRC cis rs9807989 0.839 rs4851565 chr2:102971481 C/A cg03938978 chr2:103052716 IL18RAP 0.37 5.97 0.31 6.2e-9 Asthma; CRC cis rs9467160 0.871 rs13191455 chr6:24448459 T/C cg20631270 chr6:24437470 GPLD1 0.47 6.61 0.34 1.53e-10 Liver enzyme levels; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg02157667 chr16:85722621 GINS2 0.45 6.16 0.32 2.09e-9 Response to antipsychotic treatment; CRC cis rs2032447 0.670 rs198852 chr6:26104448 A/G cg18357526 chr6:26021779 HIST1H4A -0.68 -10.18 -0.49 2.43e-21 Intelligence (multi-trait analysis); CRC trans rs7395662 1.000 rs4881994 chr11:48498139 G/T cg21153622 chr11:89784906 NA -0.48 -7.7 -0.39 1.61e-13 HDL cholesterol; CRC cis rs1799949 0.965 rs8176322 chr17:41195773 A/G cg19454999 chr17:41278357 BRCA1;NBR2 0.54 8.52 0.43 5.78e-16 Menopause (age at onset); CRC cis rs9916302 0.718 rs7219909 chr17:37706243 C/T cg15445000 chr17:37608096 MED1 0.42 9.41 0.46 9.02e-19 Glomerular filtration rate (creatinine); CRC cis rs875971 0.520 rs2420597 chr7:65915986 A/G cg12463550 chr7:65579703 CRCP 0.49 6.8 0.35 4.87e-11 Aortic root size; CRC cis rs780096 0.565 rs13022659 chr2:27743630 C/T cg12000995 chr2:27665139 KRTCAP3 -0.3 -6.04 -0.32 4.09e-9 Total body bone mineral density; CRC cis rs2011503 1.000 rs2965179 chr19:19512755 G/A cg11584989 chr19:19387371 SF4 0.55 6.36 0.33 6.6e-10 Bipolar disorder; CRC cis rs6547741 0.816 rs7560847 chr2:27882700 A/G cg27432699 chr2:27873401 GPN1 -0.86 -16.77 -0.68 4.89e-46 Oral cavity cancer; CRC cis rs929354 0.713 rs6946660 chr7:156948648 T/C cg05182265 chr7:156933206 UBE3C -0.76 -14.38 -0.62 1.04e-36 Body mass index; CRC cis rs9381040 0.610 rs2235678 chr6:41020510 G/T cg09580153 chr6:41068724 NFYA;LOC221442 -0.42 -6.14 -0.32 2.42e-9 Alzheimer's disease (late onset); CRC cis rs9733 0.569 rs11588404 chr1:150688529 C/A cg18016565 chr1:150552671 MCL1 0.45 6.52 0.34 2.57e-10 Tonsillectomy; CRC cis rs12325245 0.536 rs34161389 chr16:58622604 G/A cg19824325 chr16:58548873 SETD6 1.0 6.84 0.35 3.87e-11 Schizophrenia; CRC cis rs7666738 0.830 rs10049985 chr4:99023517 C/T cg05340658 chr4:99064831 C4orf37 0.61 9.51 0.46 4.05e-19 Colonoscopy-negative controls vs population controls; CRC cis rs2404602 0.669 rs9788684 chr15:77194838 A/T cg22467129 chr15:76604101 ETFA -0.38 -6.1 -0.32 2.99e-9 Blood metabolite levels; CRC trans rs2727020 0.538 rs11040373 chr11:49461791 T/C cg03929089 chr4:120376271 NA -0.7 -11.11 -0.52 1.47e-24 Coronary artery disease; CRC cis rs7412746 0.634 rs72704658 chr1:150833010 T/C cg18016565 chr1:150552671 MCL1 0.46 6.31 0.33 9.12e-10 Melanoma; CRC cis rs2932538 0.961 rs4240534 chr1:113175429 T/A cg22162597 chr1:113214053 CAPZA1 -0.72 -10.22 -0.49 1.78e-21 Systolic blood pressure;Diastolic blood pressure;Hypertension;Blood pressure; CRC cis rs7725052 0.609 rs7728925 chr5:40456652 T/C cg09067459 chr5:40385259 NA 0.39 6.43 0.33 4.42e-10 Pediatric autoimmune diseases; CRC cis rs4862750 1.000 rs4862750 chr4:187904043 C/T cg06074448 chr4:187884817 NA -0.61 -11.06 -0.52 2.12e-24 Lobe attachment (rater-scored or self-reported); CRC cis rs9322193 0.923 rs62439840 chr6:149995775 G/A cg07701084 chr6:150067640 NUP43 0.57 7.94 0.4 3.15e-14 Lung cancer; CRC cis rs875971 0.522 rs709604 chr7:65497434 A/G cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.52 -7.72 -0.39 1.37e-13 Aortic root size; CRC cis rs6456156 0.586 rs6909180 chr6:167460537 A/G cg07741184 chr6:167504864 NA 0.39 6.9 0.36 2.63e-11 Primary biliary cholangitis; CRC cis rs7546094 1.000 rs1994604 chr1:113156426 C/T cg22162597 chr1:113214053 CAPZA1 0.45 6.22 0.32 1.54e-9 Platelet distribution width; CRC cis rs6502050 0.842 rs8080305 chr17:80074516 A/C cg11859384 chr17:80120422 CCDC57 0.38 5.87 0.31 1.04e-8 Life satisfaction; CRC cis rs1957429 0.808 rs1951492 chr14:65346895 G/A cg23373153 chr14:65346875 NA 0.77 7.83 0.4 6.98e-14 Pediatric areal bone mineral density (radius); CRC cis rs533581 0.866 rs871756 chr16:88969076 G/C cg16701003 chr16:89028210 CBFA2T3 0.47 6.75 0.35 6.58e-11 Social autistic-like traits; CRC cis rs77861329 1.000 rs183029 chr3:52209884 A/G cg08692210 chr3:52188851 WDR51A 0.84 7.83 0.4 6.75e-14 Macrophage inflammatory protein 1b levels; CRC cis rs950169 0.887 rs62029593 chr15:84955180 A/G cg11189052 chr15:85197271 WDR73 0.63 8.8 0.44 7.65e-17 Schizophrenia; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg26685501 chr1:38019921 SNIP1 0.41 6.12 0.32 2.6e-9 Intelligence (multi-trait analysis); CRC cis rs9322193 0.962 rs9322218 chr6:150103319 A/G cg13206674 chr6:150067644 NUP43 0.54 7.76 0.39 1.11e-13 Lung cancer; CRC cis rs2120019 0.508 rs8030528 chr15:75171825 C/T cg17294928 chr15:75287854 SCAMP5 -0.62 -7.26 -0.37 2.83e-12 Blood trace element (Zn levels); CRC cis rs6120849 0.754 rs6119560 chr20:33606977 G/C cg08999081 chr20:33150536 PIGU 0.45 5.87 0.31 1.05e-8 Protein C levels; CRC cis rs425277 0.606 rs451061 chr1:2075068 C/G cg12639453 chr1:2035780 PRKCZ 0.3 5.6 0.3 4.46e-8 Height; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg05454237 chr11:14913849 CYP2R1 0.47 6.57 0.34 1.92e-10 Response to antipsychotic treatment; CRC cis rs801193 1.000 rs7789184 chr7:66210195 A/T cg11764359 chr7:65958608 NA 0.54 8.25 0.41 3.77e-15 Aortic root size; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg10309340 chr10:102747329 C10orf2;MRPL43 -0.44 -6.86 -0.35 3.39e-11 Myopia (pathological); CRC cis rs875971 0.895 rs3857684 chr7:65938158 G/C cg18876405 chr7:65276391 NA 0.52 8.89 0.44 4.24e-17 Aortic root size; CRC cis rs896854 0.967 rs1320164 chr8:95960767 G/A cg16049864 chr8:95962084 TP53INP1 -0.67 -12.39 -0.56 3.33e-29 Type 2 diabetes; CRC cis rs372883 0.600 rs2832294 chr21:30739671 A/C cg08807101 chr21:30365312 RNF160 0.59 8.46 0.42 9.13e-16 Pancreatic cancer; CRC cis rs79349575 0.778 rs12950328 chr17:46967061 C/T cg00947319 chr17:47005597 UBE2Z -0.34 -5.92 -0.31 8.16e-9 Type 2 diabetes; CRC cis rs10504229 0.815 rs75577263 chr8:58188434 A/G cg02725872 chr8:58115012 NA -0.38 -6.43 -0.33 4.44e-10 Developmental language disorder (linguistic errors); CRC trans rs10982213 0.830 rs2274163 chr9:117188714 C/T cg06585566 chr19:57276794 NA 0.35 6.33 0.33 8.14e-10 Interleukin-6 levels; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg26667821 chr1:155099774 EFNA1 0.45 6.49 0.34 3.17e-10 Response to antipsychotic treatment; CRC cis rs1552244 0.751 rs12715665 chr3:10021601 C/T cg08888203 chr3:10149979 C3orf24 0.6 8.42 0.42 1.22e-15 Alzheimer's disease; CRC cis rs1958560 0.932 rs61987994 chr14:66070733 A/G cg03016385 chr14:66212404 NA -0.45 -6.19 -0.32 1.81e-9 Menarche (age at onset); CRC cis rs7769051 0.522 rs6930703 chr6:133111266 C/T cg07930552 chr6:133119739 C6orf192 0.64 5.64 0.3 3.58e-8 Type 2 diabetes nephropathy; CRC cis rs875971 0.660 rs10950044 chr7:66042976 A/G cg00343986 chr7:65444356 GUSB -0.5 -7.51 -0.38 5.55e-13 Aortic root size; CRC cis rs9527 0.567 rs6584539 chr10:104879402 G/C cg15744005 chr10:104629667 AS3MT -0.31 -6.1 -0.32 3.05e-9 Arsenic metabolism; CRC cis rs2257205 0.667 rs8068677 chr17:56869386 G/A cg25885038 chr17:56607967 SEPT4 -0.53 -5.75 -0.3 2.07e-8 Pancreatic cancer; CRC cis rs875971 1.000 rs4718357 chr7:65960878 A/G cg18912574 chr7:65842487 NCRNA00174 0.35 6.09 0.32 3.11e-9 Aortic root size; CRC cis rs2455601 0.882 rs10840139 chr11:8894838 T/G cg21881798 chr11:8931708 C11orf17;ST5 -0.55 -6.26 -0.33 1.2e-9 Schizophrenia; CRC cis rs17818399 0.547 rs7607633 chr2:46759427 T/C cg21681030 chr2:46777652 RHOQ 0.45 6.05 0.32 3.89e-9 Height; CRC trans rs9393777 0.841 rs13191474 chr6:27413345 C/T cg06606381 chr12:133084897 FBRSL1 -1.06 -7.28 -0.37 2.49e-12 Intelligence (multi-trait analysis); CRC cis rs7618915 0.501 rs34157897 chr3:52716937 T/C cg08222913 chr3:52553049 STAB1 -0.34 -6.38 -0.33 6.15e-10 Bipolar disorder; CRC trans rs916888 0.773 rs199535 chr17:44822662 A/G cg23590916 chr17:43697445 MGC57346 0.7 7.4 0.38 1.17e-12 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs7197653 0.586 rs55856208 chr16:68324210 A/T cg05110241 chr16:68378359 PRMT7 -0.72 -7.01 -0.36 1.39e-11 Magnesium levels; CRC cis rs4713118 0.869 rs6901520 chr6:27714575 G/T cg15786705 chr6:28176104 NA 0.55 7.73 0.39 1.34e-13 Parkinson's disease; CRC cis rs2976388 0.609 rs2585152 chr8:143786214 A/T cg12516270 chr8:143859308 LYNX1 0.44 7.77 0.39 9.92e-14 Urinary tract infection frequency; CRC cis rs11628318 0.614 rs942022 chr14:103108842 C/T cg12046867 chr14:103022105 NA -0.76 -9.2 -0.45 4.16e-18 Platelet count; CRC cis rs1552244 1.000 rs6804473 chr3:10060425 C/T cg00166722 chr3:10149974 C3orf24 0.66 8.84 0.44 5.84e-17 Alzheimer's disease; CRC cis rs1865760 0.964 rs9295677 chr6:25933712 T/C cg16482183 chr6:26056742 HIST1H1C 0.53 7.44 0.38 8.72e-13 Height; CRC trans rs9858542 0.953 rs7633271 chr3:49555963 T/C cg21665057 chr3:196295764 WDR53;FBXO45 -0.65 -8.9 -0.44 3.86e-17 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs1564271 0.528 rs2489589 chr10:26983095 A/G cg13837822 chr10:26931731 LOC731789 0.56 8.54 0.43 5.12e-16 Overall survival in serous epithelial ovarian cancer treated with paclitaxel and cisplatin; CRC cis rs6502050 0.835 rs34287733 chr17:80078236 C/T cg19223190 chr17:80058835 NA -0.38 -6.05 -0.32 3.96e-9 Life satisfaction; CRC cis rs11190604 1.000 rs7078799 chr10:102301447 G/A cg07080220 chr10:102295463 HIF1AN 0.47 5.66 0.3 3.31e-8 Palmitoleic acid (16:1n-7) levels; CRC cis rs9393692 0.645 rs9467703 chr6:26318903 A/G cg00631329 chr6:26305371 NA -0.7 -12.8 -0.58 1.02e-30 Educational attainment; CRC cis rs7044106 0.791 rs10818473 chr9:123484155 A/C cg14255062 chr9:123606675 PSMD5;LOC253039 0.49 7.35 0.38 1.61e-12 Hip circumference adjusted for BMI; CRC cis rs9768139 0.733 rs56205111 chr7:158121055 T/C cg24154853 chr7:158122151 PTPRN2 0.64 10.52 0.5 1.6400000000000001e-22 Calcium levels; CRC trans rs629535 0.814 rs674429 chr8:70069942 G/A cg21567404 chr3:27674614 NA 0.93 15.32 0.65 2.37e-40 Dupuytren's disease; CRC cis rs76419734 0.558 rs10019217 chr4:106588509 C/T cg24545054 chr4:106630052 GSTCD;INTS12 0.61 7.59 0.39 3.37e-13 Post bronchodilator FEV1; CRC trans rs11671005 0.610 rs4756 chr19:59074653 T/C cg22037779 chr5:139682734 PFDN1 -0.58 -8.22 -0.41 4.6e-15 Mean platelet volume; CRC cis rs561341 0.882 rs2428337 chr17:30299467 C/T cg12193833 chr17:30244370 NA -0.75 -8.75 -0.43 1.13e-16 Hip circumference adjusted for BMI; CRC cis rs7777484 0.517 rs2644306 chr7:2831602 A/G cg09658497 chr7:2847517 GNA12 -0.4 -6.66 -0.34 1.14e-10 Height; CRC cis rs6952808 0.692 rs10950473 chr7:1999453 G/A cg20295408 chr7:1910781 MAD1L1 -0.43 -5.93 -0.31 7.87e-9 Bipolar disorder and schizophrenia; CRC cis rs10256972 0.684 rs4724039 chr7:1111633 A/G cg18402987 chr7:1209562 NA 0.43 6.47 0.34 3.54e-10 Longevity;Endometriosis; CRC cis rs10504229 0.906 rs58251024 chr8:58172259 G/C cg05313129 chr8:58192883 C8orf71 -0.47 -6.99 -0.36 1.49e-11 Developmental language disorder (linguistic errors); CRC cis rs10504229 0.593 rs17794451 chr8:58019217 C/T cg02725872 chr8:58115012 NA -0.52 -7.24 -0.37 3.13e-12 Developmental language disorder (linguistic errors); CRC cis rs6723226 0.750 rs10182170 chr2:32704186 G/A cg02381751 chr2:32503542 YIPF4 0.54 7.89 0.4 4.38e-14 Intelligence (multi-trait analysis); CRC cis rs13191362 1.000 rs73035023 chr6:163000927 C/T cg23758597 chr6:163146217 PARK2 -0.56 -6.17 -0.32 1.98e-9 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs9341808 0.905 rs3805903 chr6:80975829 T/C cg08355045 chr6:80787529 NA 0.36 6.11 0.32 2.86e-9 Sitting height ratio; CRC cis rs6502050 0.835 rs12950475 chr17:80118924 T/C cg19223190 chr17:80058835 NA 0.39 6.23 0.32 1.43e-9 Life satisfaction; CRC cis rs909002 0.830 rs7542583 chr1:32110813 A/G cg01639898 chr1:32083012 HCRTR1 0.31 6.42 0.33 4.69e-10 Intelligence (multi-trait analysis); CRC cis rs6582630 0.519 rs4436613 chr12:38293653 T/C cg13010199 chr12:38710504 ALG10B 0.46 6.25 0.33 1.25e-9 Drug-induced liver injury (flucloxacillin); CRC cis rs7618915 0.547 rs13085331 chr3:52627486 G/C cg18404041 chr3:52824283 ITIH1 -0.43 -8.72 -0.43 1.39e-16 Bipolar disorder; CRC cis rs34311866 0.808 rs17783233 chr4:976598 T/C cg07828340 chr4:882639 GAK 0.92 8.92 0.44 3.35e-17 Parkinson's disease; CRC cis rs7618915 0.547 rs1561337 chr3:52659963 C/T cg15147215 chr3:52552868 STAB1 -0.6 -10.0 -0.48 9.92e-21 Bipolar disorder; CRC cis rs12477438 1.000 rs73963398 chr2:99887025 T/C cg14399236 chr2:99771627 LIPT1;TSGA10 -0.76 -9.31 -0.46 1.88e-18 Chronic sinus infection; CRC cis rs926938 0.527 rs360684 chr1:115499001 A/G cg12756093 chr1:115239321 AMPD1 0.48 7.08 0.36 8.63e-12 Autism; CRC cis rs2153535 1.000 rs2153535 chr6:8369679 C/G cg07606381 chr6:8435919 SLC35B3 -0.41 -6.08 -0.32 3.27e-9 Motion sickness; CRC trans rs6000782 0.590 rs1079981 chr22:37929464 A/G cg01410359 chr2:38302230 CYP1B1 0.45 6.01 0.31 4.9e-9 Autoimmune hepatitis type-1; CRC cis rs73206853 0.686 rs7974047 chr12:111119631 C/T cg12870014 chr12:110450643 ANKRD13A 0.76 8.03 0.4 1.8e-14 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC trans rs1814175 0.817 rs10839358 chr11:49770972 G/A cg21153622 chr11:89784906 NA -0.37 -5.98 -0.31 5.8e-9 Height; CRC cis rs17767392 0.957 rs35692397 chr14:71756683 A/C cg13720639 chr14:72061746 SIPA1L1 -0.53 -6.82 -0.35 4.34e-11 Mitral valve prolapse; CRC cis rs11190604 1.000 rs10786598 chr10:102291579 G/A cg16342193 chr10:102329863 NA -0.36 -5.94 -0.31 7.21e-9 Palmitoleic acid (16:1n-7) levels; CRC cis rs748404 0.697 rs492743 chr15:43560945 A/G cg02155558 chr15:43621948 ADAL;LCMT2 0.41 6.18 0.32 1.95e-9 Lung cancer; CRC cis rs9811920 0.609 rs9817005 chr3:99682692 T/C cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G -0.46 -6.19 -0.32 1.79e-9 Axial length; CRC cis rs4604732 0.642 rs4266925 chr1:247639165 T/C cg02104434 chr1:247694406 LOC148824;OR2C3 0.41 6.74 0.35 7.19e-11 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CRC cis rs965469 0.857 rs6037523 chr20:3249463 A/T cg25506879 chr20:3388711 C20orf194 -0.38 -5.75 -0.3 2e-8 IFN-related cytopenia; CRC cis rs12024301 0.557 rs10911385 chr1:183606183 G/C cg11505048 chr1:183622726 RGL1;APOBEC4 0.77 6.73 0.35 7.45e-11 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs7044106 0.708 rs991121 chr9:123370345 C/G cg09419670 chr9:123605666 PSMD5;LOC253039 0.65 10.5 0.5 1.98e-22 Hip circumference adjusted for BMI; CRC cis rs7843479 1.000 rs7843479 chr8:21820813 G/T cg17168535 chr8:21777572 XPO7 0.55 8.67 0.43 2.01e-16 Mean corpuscular volume; CRC cis rs4727963 0.511 rs846655 chr7:122645560 A/G cg03640110 chr7:122635026 TAS2R16 -0.52 -10.08 -0.49 5.33e-21 Adverse response to chemotherapy (neutropenia/leucopenia) (docetaxel); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg16925090 chr11:101785516 KIAA1377;ANGPTL5 0.46 6.71 0.35 8.64e-11 Response to antipsychotic treatment; CRC cis rs2797160 1.000 rs2747723 chr6:126010790 C/T cg05901451 chr6:126070800 HEY2 0.38 5.96 0.31 6.37e-9 Endometrial cancer; CRC cis rs9296092 0.538 rs7761464 chr6:33519417 C/A cg13560919 chr6:33536144 NA -0.45 -6.28 -0.33 1.07e-9 Age at smoking initiation in chronic obstructive pulmonary disease; CRC cis rs1997103 0.871 rs1997100 chr7:55399656 C/G cg17469321 chr7:55412551 NA 0.73 11.31 0.53 2.75e-25 QRS interval (sulfonylurea treatment interaction); CRC cis rs10791097 0.668 rs10791102 chr11:130744977 G/A cg12179176 chr11:130786555 SNX19 0.75 12.66 0.57 3.46e-30 Autism spectrum disorder or schizophrenia;Schizophrenia; CRC trans rs561341 1.000 rs72823785 chr17:30273784 C/T cg27661571 chr11:113659931 NA -0.95 -11.08 -0.52 1.91e-24 Hip circumference adjusted for BMI; CRC cis rs9368481 0.729 rs9379950 chr6:26961548 T/C cg18867708 chr6:26865862 GUSBL1 -0.42 -5.89 -0.31 9.8e-9 Autism spectrum disorder or schizophrenia; CRC cis rs6860806 0.507 rs273901 chr5:131694360 G/T cg18758796 chr5:131593413 PDLIM4 0.4 6.46 0.34 3.83e-10 Breast cancer; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg03323938 chr19:39663667 PAK4 -0.36 -5.98 -0.31 5.73e-9 Liver disease severity in Alagille syndrome; CRC cis rs7786808 0.536 rs4909210 chr7:158194376 T/C cg09998033 chr7:158218633 PTPRN2 -0.44 -5.89 -0.31 9.38e-9 Obesity-related traits; CRC cis rs2295359 1.000 rs2295359 chr1:67635950 G/A cg03340356 chr1:67600835 NA 0.25 5.71 0.3 2.52e-8 Psoriasis; CRC cis rs2302190 0.882 rs7226008 chr17:56644633 T/C cg25885038 chr17:56607967 SEPT4 -0.51 -7.72 -0.39 1.44e-13 Vitamin D levels; CRC trans rs10021731 0.718 rs1585447 chr4:115412068 G/C cg25927708 chr2:119603813 EN1 -0.33 -6.01 -0.31 4.92e-9 Optic disc area; CRC cis rs13191362 0.507 rs13212746 chr6:163203092 T/C cg21926612 chr6:163149169 PACRG;PARK2 0.57 8.95 0.44 2.71e-17 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC trans rs10504229 0.906 rs72650894 chr8:58179734 C/T cg04077850 chr5:125800366 GRAMD3 0.37 6.27 0.33 1.15e-9 Developmental language disorder (linguistic errors); CRC trans rs2975734 0.680 rs1052453 chr8:10108325 C/T cg06636001 chr8:8085503 FLJ10661 -0.54 -7.59 -0.39 3.24e-13 Morning vs. evening chronotype;Chronotype; CRC cis rs939584 1.000 rs10190313 chr2:647577 A/G cg03610516 chr2:642275 NA 0.41 5.93 0.31 7.83e-9 Body mass index; CRC cis rs1448094 0.549 rs7297996 chr12:86235899 C/T cg19622623 chr12:86230825 RASSF9 -0.41 -6.57 -0.34 1.94e-10 Major depressive disorder; CRC cis rs4891159 0.513 rs35534021 chr18:74130523 G/A cg24786174 chr18:74118243 ZNF516 0.89 21.05 0.76 6.83e-63 Longevity; CRC cis rs2153535 0.541 rs945304 chr6:8442892 A/G cg21535247 chr6:8435926 SLC35B3 0.48 7.3 0.37 2.21e-12 Motion sickness; CRC cis rs6952808 0.792 rs4721184 chr7:1950784 T/C cg00106254 chr7:1943704 MAD1L1 -0.51 -7.47 -0.38 7.52e-13 Bipolar disorder and schizophrenia; CRC trans rs11026407 0.967 rs7127246 chr11:22060228 C/G cg13567813 chr19:50879636 NR1H2 -0.61 -6.13 -0.32 2.49e-9 Plasma thyroid-stimulating hormone levels; CRC trans rs963731 0.649 rs297129 chr2:39299271 C/T cg13401531 chr11:70333281 SHANK2 -0.69 -6.1 -0.32 3.02e-9 Corticobasal degeneration; CRC cis rs11864453 0.647 rs9932062 chr16:72136055 T/C cg23815491 chr16:72088622 HP 0.49 7.51 0.38 5.77e-13 Fibrinogen levels; CRC cis rs9925964 0.869 rs749670 chr16:31088625 A/G cg02466173 chr16:30829666 NA 0.43 5.87 0.31 1.09e-8 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs2115630 0.645 rs3825877 chr15:85174631 G/A cg11189052 chr15:85197271 WDR73 -0.68 -11.51 -0.54 5.59e-26 P wave terminal force; CRC cis rs7811142 0.830 rs6975660 chr7:99975266 A/G cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.75 10.58 0.5 1.02e-22 Platelet count; CRC cis rs7647973 1.000 rs6783003 chr3:49524778 G/C cg07690219 chr3:49449608 TCTA;RHOA 0.53 5.81 0.31 1.46e-8 Menarche (age at onset); CRC cis rs3617 0.625 rs11719137 chr3:52876389 G/T cg18099408 chr3:52552593 STAB1 0.34 5.83 0.31 1.35e-8 Red blood cell count;Autism spectrum disorder or schizophrenia; CRC cis rs709400 0.526 rs11622835 chr14:103967504 G/A cg07514618 chr14:103979422 NA -0.44 -6.9 -0.36 2.66e-11 Body mass index; CRC cis rs35110281 0.744 rs162373 chr21:44927107 C/A cg04455712 chr21:45112962 RRP1B -0.39 -7.54 -0.38 4.74e-13 Mean corpuscular volume; CRC cis rs11122272 0.735 rs2808611 chr1:231548480 A/G cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX 0.56 8.45 0.42 9.27e-16 Hemoglobin concentration; CRC trans rs4942242 0.663 rs9525815 chr13:44223692 T/C cg19169023 chr15:41853346 TYRO3 -0.61 -8.59 -0.43 3.43e-16 Response to tocilizumab in rheumatoid arthritis; CRC cis rs5769765 0.908 rs138866 chr22:50205903 A/G cg22709217 chr22:50311962 ALG12;CRELD2 0.89 14.08 0.61 1.49e-35 Schizophrenia; CRC cis rs10492096 1.000 rs12427239 chr12:6590626 C/T cg07142400 chr12:6602447 NCAPD2;MRPL51 -0.49 -5.77 -0.3 1.86e-8 Hip geometry; CRC cis rs8060686 0.858 rs8057986 chr16:67893879 A/G cg07125278 chr16:67683757 RLTPR -0.48 -6.6 -0.34 1.68e-10 HDL cholesterol;Metabolic syndrome; CRC cis rs1941023 0.584 rs2197236 chr11:60168859 T/C cg08716584 chr11:60157161 MS4A7 -0.55 -8.99 -0.44 2.04e-17 Congenital heart disease (maternal effect); CRC cis rs1580019 0.522 rs10951340 chr7:32562408 G/A cg14728415 chr7:32535168 LSM5;AVL9 0.43 6.02 0.32 4.59e-9 Cognitive ability; CRC cis rs7119 0.717 rs62009071 chr15:77817886 C/G cg27398640 chr15:77910606 LINGO1 -0.43 -7.47 -0.38 7.13e-13 Type 2 diabetes; CRC cis rs4803455 0.565 rs1800470 chr19:41858921 G/A cg08477640 chr19:41863820 B9D2 0.48 7.46 0.38 7.65e-13 Migraine;Coronary artery disease; CRC cis rs1348850 0.958 rs4528793 chr2:178464271 C/T cg22681709 chr2:178499509 PDE11A -0.33 -6.08 -0.32 3.37e-9 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs853679 0.517 rs9295759 chr6:28124469 C/T cg21251018 chr6:28226885 NKAPL 0.48 6.17 0.32 2.02e-9 Depression; CRC cis rs13108904 0.901 rs12641735 chr4:1304434 G/C cg15763984 chr4:1342303 KIAA1530 0.34 5.69 0.3 2.76e-8 Obesity-related traits; CRC cis rs2811415 0.597 rs2878507 chr3:127793923 G/A cg13719885 chr3:127795394 NA -0.39 -5.86 -0.31 1.12e-8 Lung function (FEV1/FVC); CRC cis rs9486719 0.656 rs4839826 chr6:96853616 A/G cg06623918 chr6:96969491 KIAA0776 -0.79 -10.77 -0.51 2.25e-23 Migraine;Coronary artery disease; CRC cis rs1046896 0.553 rs1044661 chr17:80901020 G/A cg03160526 chr17:80928410 B3GNTL1 0.64 8.89 0.44 4.14e-17 Glycated hemoglobin levels; CRC cis rs6502050 0.835 rs35857672 chr17:80078303 G/A cg19223190 chr17:80058835 NA -0.39 -6.06 -0.32 3.63e-9 Life satisfaction; CRC cis rs950776 0.593 rs555018 chr15:78879242 G/A cg06917634 chr15:78832804 PSMA4 -0.58 -9.0 -0.44 1.83e-17 Sudden cardiac arrest; CRC cis rs3996993 0.809 rs4144185 chr6:52702948 A/G cg20803780 chr6:52668592 GSTA1 -0.36 -6.74 -0.35 7.18e-11 Hemoglobin concentration; CRC cis rs2739330 0.760 rs5760095 chr22:24247293 A/G cg11060661 chr22:24314208 DDT;DDTL 0.48 8.09 0.41 1.14e-14 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs1448094 0.512 rs61930864 chr12:86246740 G/A cg19622623 chr12:86230825 RASSF9 -0.41 -6.74 -0.35 7.23e-11 Major depressive disorder; CRC cis rs1448094 0.512 rs10863086 chr12:86244225 G/A cg19622623 chr12:86230825 RASSF9 -0.41 -6.7 -0.35 9.04e-11 Major depressive disorder; CRC cis rs9443645 0.869 rs2095724 chr6:79742101 C/T cg11833968 chr6:79620685 NA -0.36 -6.1 -0.32 2.99e-9 Intelligence (multi-trait analysis); CRC cis rs951366 0.789 rs823152 chr1:205736285 G/A cg26354017 chr1:205819088 PM20D1 0.77 11.67 0.54 1.46e-26 Menarche (age at onset); CRC cis rs10504229 0.728 rs17804666 chr8:58154473 C/T cg02725872 chr8:58115012 NA -0.57 -9.07 -0.45 1.09e-17 Developmental language disorder (linguistic errors); CRC cis rs12594515 1.000 rs6493170 chr15:45987019 G/A cg06207120 chr15:45996521 NA 0.32 7.82 0.4 7.26e-14 Waist circumference;Weight; CRC cis rs9916302 0.851 rs9909064 chr17:37500434 G/T cg00129232 chr17:37814104 STARD3 0.54 7.97 0.4 2.68e-14 Glomerular filtration rate (creatinine); CRC cis rs11252926 0.574 rs4881254 chr10:453567 C/T cg18196295 chr10:418757 DIP2C 0.48 7.53 0.38 4.84e-13 Psychosis in Alzheimer's disease; CRC cis rs807669 0.548 rs762522 chr22:19180575 C/T cg02655711 chr22:19163373 SLC25A1 0.79 14.23 0.62 3.84e-36 Metabolite levels; CRC cis rs9469890 0.604 rs78121911 chr6:34503739 T/C cg17674042 chr6:34482479 PACSIN1 -0.67 -7.79 -0.39 8.91e-14 Pubertal anthropometrics;Coronary artery disease; CRC cis rs2839186 0.526 rs2839297 chr21:47921839 A/G cg13012494 chr21:47604986 C21orf56 0.42 6.39 0.33 5.8e-10 Testicular germ cell tumor; CRC cis rs932287 0.536 rs10840160 chr11:9053536 C/T cg21881798 chr11:8931708 C11orf17;ST5 -0.54 -8.04 -0.41 1.66e-14 Colonoscopy-negative controls vs population controls; CRC trans rs6601327 0.641 rs4129360 chr8:9573284 T/A cg06636001 chr8:8085503 FLJ10661 -0.51 -7.42 -0.38 1.03e-12 Multiple myeloma (hyperdiploidy); CRC cis rs13108904 0.934 rs13125842 chr4:1280947 G/A cg00684032 chr4:1343700 KIAA1530 0.48 6.99 0.36 1.54e-11 Obesity-related traits; CRC cis rs13191362 1.000 rs13192894 chr6:163052444 T/A cg14584255 chr6:163149320 PACRG;PARK2 0.43 6.05 0.32 3.89e-9 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs2204008 0.560 rs1315354 chr12:38165716 A/G cg13010199 chr12:38710504 ALG10B -0.43 -6.17 -0.32 1.96e-9 Bladder cancer; CRC cis rs1008375 1.000 rs6854733 chr4:17640526 C/T cg02297831 chr4:17616191 MED28 0.44 5.83 0.31 1.29e-8 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs9858542 1.000 rs11718165 chr3:49696797 A/G cg03060546 chr3:49711283 APEH -0.53 -7.32 -0.37 1.94e-12 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs10208940 0.920 rs6724540 chr2:68779356 A/G cg12452813 chr2:68675892 NA 0.47 5.9 0.31 9.19e-9 Urate levels in lean individuals; CRC cis rs798554 0.757 rs1182172 chr7:2878103 G/A cg19717773 chr7:2847554 GNA12 -0.48 -6.79 -0.35 5.35e-11 Height; CRC cis rs1158570 0.500 rs7846376 chr8:131155443 G/A cg26053073 chr8:131455383 NA -0.41 -6.22 -0.32 1.51e-9 Platelet count; CRC cis rs10924970 0.781 rs10802589 chr1:235444049 A/G cg26050004 chr1:235667680 B3GALNT2 0.4 6.01 0.31 4.84e-9 Asthma; CRC cis rs4728302 0.559 rs7779409 chr7:133158475 A/G cg10665199 chr7:133106180 EXOC4 0.67 10.41 0.5 4.15e-22 Intelligence;Intelligence (multi-trait analysis); CRC trans rs7395662 0.864 rs10839201 chr11:48989417 A/G cg21153622 chr11:89784906 NA 0.49 7.98 0.4 2.4e-14 HDL cholesterol; CRC trans rs617791 0.530 rs735942 chr11:65749337 A/G cg17712092 chr4:129076599 LARP1B -0.49 -7.15 -0.37 5.65e-12 Breast cancer; CRC cis rs10071761 0.513 rs56952742 chr5:40368332 A/G cg09067459 chr5:40385259 NA -0.53 -7.11 -0.37 7.18e-12 Selective IgA deficiency; CRC cis rs4332037 0.664 rs73046334 chr7:1887037 T/C cg23378565 chr7:2036160 MAD1L1 -0.4 -6.04 -0.32 4.16e-9 Bipolar disorder; CRC cis rs12497850 0.931 rs13064784 chr3:49135961 C/G cg20833759 chr3:49053208 WDR6;DALRD3 0.47 7.94 0.4 3.18e-14 Parkinson's disease; CRC cis rs11212617 0.934 rs2056267 chr11:108061808 C/A cg14761454 chr11:108092087 ATM;NPAT 0.39 5.85 0.31 1.2e-8 Response to metformin in type 2 diabetes (glycemic); CRC trans rs12478296 1.000 rs6717667 chr2:242997530 C/T cg06834434 chr14:75079333 LTBP2 0.51 6.14 0.32 2.31e-9 Obesity-related traits; CRC cis rs8078723 0.738 rs4065321 chr17:38143548 C/T cg17467752 chr17:38218738 THRA -0.57 -8.94 -0.44 2.79e-17 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); CRC cis rs10504229 0.953 rs78089850 chr8:58171557 A/G cg02290350 chr8:58132656 NA -0.42 -5.9 -0.31 8.92e-9 Developmental language disorder (linguistic errors); CRC cis rs7107174 1.000 rs1893447 chr11:77973182 A/G cg02023728 chr11:77925099 USP35 0.53 8.99 0.44 1.95e-17 Testicular germ cell tumor; CRC cis rs9611519 0.780 rs1983631 chr22:41644074 C/T cg03806693 chr22:41940476 POLR3H -0.66 -9.41 -0.46 8.95e-19 Neuroticism; CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg21638108 chr19:19431283 KIAA0892;SF4 0.38 6.31 0.33 9.07e-10 Obesity-related traits; CRC cis rs6662572 0.737 rs4518839 chr1:46376690 G/T cg03123370 chr1:45965343 CCDC163P;MMACHC -0.46 -5.85 -0.31 1.21e-8 Blood protein levels; CRC cis rs863345 0.604 rs11265008 chr1:158498671 C/T cg12129480 chr1:158549410 OR10X1 -0.3 -6.27 -0.33 1.12e-9 Pneumococcal bacteremia; CRC cis rs10504229 0.871 rs10504227 chr8:58162005 G/A cg21724239 chr8:58056113 NA 0.4 6.02 0.31 4.76e-9 Developmental language disorder (linguistic errors); CRC cis rs6693567 0.545 rs2012751 chr1:150438266 T/C cg15654264 chr1:150340011 RPRD2 0.42 6.19 0.32 1.76e-9 Migraine; CRC cis rs2933343 1.000 rs2929859 chr3:128608341 T/G cg11901034 chr3:128598214 ACAD9 -0.5 -6.23 -0.32 1.44e-9 IgG glycosylation; CRC cis rs853679 0.517 rs9366715 chr6:28064633 A/G cg12273811 chr6:28175739 NA 0.73 9.31 0.46 1.82e-18 Depression; CRC cis rs12431939 0.948 rs67116854 chr14:51670464 G/A cg23942311 chr14:51606299 NA -0.53 -6.35 -0.33 7.21e-10 Cancer; CRC cis rs4243830 0.850 rs2412309 chr1:6603151 A/G cg05709478 chr1:6581295 PLEKHG5 -0.57 -6.75 -0.35 6.83e-11 Body mass index; CRC cis rs2991971 0.869 rs2453404 chr1:46014735 A/G cg15605315 chr1:45957053 TESK2 0.42 6.7 0.35 9.31e-11 High light scatter reticulocyte count; CRC cis rs7737355 0.947 rs56228197 chr5:130805475 C/T cg06307176 chr5:131281290 NA -0.42 -6.31 -0.33 8.8e-10 Life satisfaction; CRC cis rs7725052 0.609 rs10052842 chr5:40450848 G/A cg09067459 chr5:40385259 NA -0.4 -6.61 -0.34 1.53e-10 Pediatric autoimmune diseases; CRC cis rs4862307 0.836 rs11132220 chr4:184997247 A/T cg06737308 chr4:185021514 ENPP6 -0.46 -7.48 -0.38 6.93e-13 Serum dimethylarginine levels (asymmetric/symetric ratio); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg25832598 chr1:247094143 AHCTF1 0.41 6.01 0.31 4.88e-9 Response to antipsychotic treatment; CRC cis rs55794721 0.543 rs1293260 chr1:25709104 C/G cg20684491 chr1:25596433 NA 0.43 7.68 0.39 1.88e-13 Plateletcrit;Mean corpuscular volume; CRC cis rs9463078 0.774 rs12199720 chr6:45307443 C/T cg25276700 chr6:44698697 NA 0.29 6.98 0.36 1.6e-11 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; CRC cis rs9916302 0.904 rs7503705 chr17:37669704 A/G cg15445000 chr17:37608096 MED1 0.43 9.59 0.47 2.25e-19 Glomerular filtration rate (creatinine); CRC cis rs17253792 0.642 rs10483648 chr14:56104278 T/C cg01858014 chr14:56050164 KTN1 -0.87 -7.25 -0.37 3.01e-12 Putamen volume; CRC cis rs916888 0.779 rs199528 chr17:44843136 C/T cg01570182 chr17:44337453 NA 1.28 14.22 0.62 4.24e-36 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs7666738 0.716 rs6814353 chr4:99074202 A/G cg05340658 chr4:99064831 C4orf37 0.57 8.52 0.43 5.9e-16 Colonoscopy-negative controls vs population controls; CRC trans rs561341 1.000 rs506766 chr17:30289659 T/C cg27661571 chr11:113659931 NA -0.98 -10.93 -0.52 6.31e-24 Hip circumference adjusted for BMI; CRC cis rs669446 0.533 rs4660261 chr1:44229597 G/A cg12908607 chr1:44402522 ARTN -0.34 -6.06 -0.32 3.7e-9 Amyotrophic lateral sclerosis (age of onset); CRC cis rs1799949 1.000 rs3092994 chr17:41215825 C/T cg23758822 chr17:41437982 NA 0.8 13.54 0.6 1.66e-33 Menopause (age at onset); CRC cis rs425277 0.583 rs4648807 chr1:2040898 A/G cg24578937 chr1:2090814 PRKCZ -0.42 -7.75 -0.39 1.16e-13 Height; CRC cis rs7618915 0.570 rs11714088 chr3:52758942 A/C cg11645453 chr3:52864694 ITIH4 0.35 6.02 0.32 4.62e-9 Bipolar disorder; CRC cis rs7666738 0.830 rs13137859 chr4:99050319 A/G cg05340658 chr4:99064831 C4orf37 0.6 9.35 0.46 1.4e-18 Colonoscopy-negative controls vs population controls; CRC cis rs4332037 0.539 rs55988458 chr7:2059761 G/A cg13880726 chr7:1868755 MAD1L1 -0.47 -5.78 -0.3 1.75e-8 Bipolar disorder; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg05278650 chr3:13009132 IQSEC1 -0.42 -6.31 -0.33 9.01e-10 Myopia (pathological); CRC cis rs9614461 0.609 rs9614653 chr22:45767391 A/G cg01808030 chr22:45809952 RIBC2;SMC1B -0.61 -6.89 -0.36 2.87e-11 Tonsillectomy; CRC cis rs6502050 0.799 rs34448080 chr17:80121275 A/G cg25804541 chr17:80189381 SLC16A3 -0.31 -5.95 -0.31 6.84e-9 Life satisfaction; CRC cis rs7618915 0.547 rs2590846 chr3:52692359 C/G cg11645453 chr3:52864694 ITIH4 0.36 6.22 0.32 1.48e-9 Bipolar disorder; CRC cis rs9783347 1.000 rs4150610 chr11:18364140 A/G cg15585147 chr11:18324498 HPS5 0.45 6.32 0.33 8.5e-10 Pancreatic cancer; CRC trans rs9900280 1.000 rs8081267 chr17:27763910 G/T cg15051795 chr19:1816298 MIR1909;REXO1 -0.46 -6.05 -0.32 3.89e-9 Mean platelet volume; CRC cis rs1559088 0.576 rs11084707 chr19:33612873 C/T cg17764715 chr19:33622953 WDR88 0.46 6.82 0.35 4.49e-11 Bone ultrasound measurement (broadband ultrasound attenuation); CRC trans rs6951245 0.872 rs76713558 chr7:1095866 A/G cg13565492 chr6:43139072 SRF -0.71 -7.38 -0.38 1.32e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs853679 0.517 rs868987 chr6:28110148 A/G cg15845792 chr6:28175446 NA -1.0 -13.56 -0.6 1.39e-33 Depression; CRC cis rs12474201 0.928 rs17822019 chr2:46934505 T/C cg06386533 chr2:46925753 SOCS5 0.8 13.15 0.59 4.87e-32 Height; CRC trans rs561341 0.882 rs16967101 chr17:30377162 A/G cg20587970 chr11:113659929 NA -1.1 -15.94 -0.66 8.66e-43 Hip circumference adjusted for BMI; CRC cis rs3823572 0.542 rs10224226 chr7:133626662 G/A cg03336402 chr7:133662267 EXOC4 0.68 10.39 0.5 4.76e-22 Intelligence (multi-trait analysis); CRC cis rs6964587 0.839 rs10236107 chr7:91485461 G/A cg17063962 chr7:91808500 NA -0.7 -11.61 -0.54 2.42e-26 Breast cancer; CRC cis rs3823572 0.564 rs4728305 chr7:133666949 C/T cg03336402 chr7:133662267 EXOC4 -0.67 -10.6 -0.5 8.85e-23 Intelligence (multi-trait analysis); CRC cis rs7223966 0.960 rs11659013 chr17:61869559 C/G cg23090583 chr17:61904693 PSMC5;FTSJ3 0.51 6.27 0.33 1.16e-9 Hip circumference adjusted for BMI;Body mass index; CRC cis rs12681287 0.511 rs7839601 chr8:87503839 G/C cg27223183 chr8:87520930 FAM82B -0.52 -7.4 -0.38 1.13e-12 Caudate activity during reward; CRC trans rs8073060 0.671 rs9894813 chr17:33873848 C/T cg19694781 chr19:47549865 TMEM160 0.73 9.69 0.47 1.05e-19 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; CRC cis rs4665809 1.000 rs6709595 chr2:26259885 A/G cg22920501 chr2:26401640 FAM59B -0.49 -6.83 -0.35 4.12e-11 Gut microbiome composition (summer); CRC cis rs7618915 0.547 rs11714419 chr3:52628816 A/G cg05573699 chr3:52720067 GNL3;PBRM1 -0.45 -6.26 -0.33 1.19e-9 Bipolar disorder; CRC cis rs3820068 0.603 rs7516453 chr1:15972558 C/G cg27534772 chr1:16042836 PLEKHM2 0.54 9.65 0.47 1.41e-19 Systolic blood pressure; CRC cis rs801193 0.591 rs4506088 chr7:66135457 G/A cg11764359 chr7:65958608 NA -0.59 -8.67 -0.43 1.98e-16 Aortic root size; CRC cis rs2404602 0.583 rs2139190 chr15:76555539 G/C cg03037974 chr15:76606532 NA 0.83 17.0 0.68 5.85e-47 Blood metabolite levels; CRC cis rs7666738 0.830 rs7673385 chr4:99024922 T/G cg05340658 chr4:99064831 C4orf37 0.59 8.97 0.44 2.22e-17 Colonoscopy-negative controls vs population controls; CRC cis rs2735413 0.837 rs4888735 chr16:78083742 C/T cg04733911 chr16:78082701 NA -0.45 -7.42 -0.38 1.03e-12 Systolic blood pressure (alcohol consumption interaction); CRC cis rs7811142 1.000 rs11773661 chr7:100073069 G/C cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.99 13.27 0.59 1.79e-32 Platelet count; CRC trans rs4272382 1 rs4272382 chr8:8433488 C/T cg13072446 chr1:151019727 C1orf56;BNIPL -0.53 -5.96 -0.31 6.32e-9 Response to cytidine analogues (gemcitabine); CRC trans rs1864729 1.000 rs1835743 chr8:98282643 T/C cg08679828 chr8:102218111 ZNF706 -0.63 -7.54 -0.38 4.76e-13 Estradiol plasma levels (breast cancer); CRC cis rs10489202 0.683 rs4657730 chr1:168072738 A/T cg24449463 chr1:168025552 DCAF6 -0.53 -7.31 -0.37 2.09e-12 Schizophrenia; CRC cis rs1577917 0.740 rs6926049 chr6:86266133 G/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A 0.66 8.73 0.43 1.33e-16 Response to antipsychotic treatment; CRC cis rs9311474 0.508 rs17052259 chr3:52593138 A/G cg10802521 chr3:52805072 NEK4 -0.56 -8.91 -0.44 3.55e-17 Electroencephalogram traits; CRC trans rs12310956 0.532 rs10844715 chr12:33968444 A/G cg26384229 chr12:38710491 ALG10B 0.44 5.97 0.31 6.06e-9 Morning vs. evening chronotype; CRC cis rs10876993 0.890 rs774891 chr12:58068571 G/A cg15848620 chr12:58087721 OS9 -0.63 -8.65 -0.43 2.26e-16 Celiac disease or Rheumatoid arthritis; CRC cis rs6502050 0.835 rs6502065 chr17:80095642 T/C cg19223190 chr17:80058835 NA 0.4 6.36 0.33 6.88e-10 Life satisfaction; CRC cis rs2692947 0.727 rs893173 chr2:96789787 T/C cg23100626 chr2:96804247 ASTL 0.32 8.93 0.44 2.97e-17 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; CRC cis rs1552244 1.000 rs6442150 chr3:10122575 T/C cg08888203 chr3:10149979 C3orf24 0.73 10.16 0.49 2.86e-21 Alzheimer's disease; CRC trans rs1814175 0.935 rs7950947 chr11:49668369 C/T cg03929089 chr4:120376271 NA -0.94 -17.35 -0.69 2.52e-48 Height; CRC cis rs1475911 1.000 rs34421316 chr21:43513989 C/T cg14562523 chr21:43528734 C21orf128;UMODL1 -0.46 -6.11 -0.32 2.8e-9 IgG glycosylation; CRC cis rs2282802 0.685 rs1347143 chr5:139669386 A/G cg26211634 chr5:139558579 C5orf32 -0.42 -7.28 -0.37 2.52e-12 Intelligence (multi-trait analysis); CRC cis rs7772486 0.686 rs9403739 chr6:146015357 A/G cg23711669 chr6:146136114 FBXO30 -0.64 -10.55 -0.5 1.31e-22 Lobe attachment (rater-scored or self-reported); CRC cis rs78077440 1.000 rs78951062 chr5:40323887 C/A cg09067459 chr5:40385259 NA -0.54 -5.88 -0.31 9.99e-9 Multiple sclerosis; CRC cis rs7208859 0.673 rs2269915 chr17:29233344 C/T cg01831904 chr17:28903510 LRRC37B2 -0.56 -5.83 -0.31 1.35e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs7647973 0.516 rs4308307 chr3:49193216 C/T cg03060546 chr3:49711283 APEH 0.44 6.43 0.33 4.5e-10 Menarche (age at onset); CRC cis rs939574 0.722 rs115402093 chr2:220096128 C/T cg00496455 chr2:220118770 TUBA4A;TUBA4B 0.91 8.25 0.41 3.84e-15 Platelet distribution width; CRC cis rs8072100 0.544 rs7214993 chr17:45386797 C/G cg25173405 chr17:45401733 C17orf57 -0.46 -7.05 -0.36 1.06e-11 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC trans rs2228479 0.717 rs62052210 chr16:89980158 A/G cg21302420 chr1:112162376 RAP1A 0.62 6.29 0.33 9.82e-10 Skin colour saturation; CRC cis rs11758351 0.925 rs10452600 chr6:26192502 C/A cg22723502 chr6:26240528 HIST1H4F -0.38 -5.83 -0.31 1.35e-8 Gout;Renal underexcretion gout; CRC cis rs7715806 0.500 rs888788 chr5:74988336 C/T cg19683494 chr5:74908142 NA 0.59 6.58 0.34 1.81e-10 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs35110281 0.748 rs4997353 chr21:45002329 A/C cg01579765 chr21:45077557 HSF2BP -0.35 -6.72 -0.35 8.09e-11 Mean corpuscular volume; CRC cis rs72945132 0.882 rs55738915 chr11:70190019 C/T cg14191688 chr11:70257035 CTTN 0.43 5.74 0.3 2.12e-8 Coronary artery disease; CRC cis rs798554 0.679 rs2644281 chr7:2886748 A/G cg04166393 chr7:2884313 GNA12 0.55 7.74 0.39 1.23e-13 Height; CRC cis rs2522056 0.808 rs1016988 chr5:131744574 T/C cg24060327 chr5:131705240 SLC22A5 0.48 6.46 0.34 3.73e-10 Lymphocyte counts;Fibrinogen; CRC cis rs10979 1.000 rs9386034 chr6:143890572 T/G cg25407410 chr6:143891975 LOC285740 -0.82 -13.4 -0.59 5.5e-33 Hypospadias; CRC cis rs9399135 0.967 rs2297338 chr6:135375762 G/A cg24558204 chr6:135376177 HBS1L 0.49 7.69 0.39 1.67e-13 Red blood cell count; CRC cis rs870825 0.616 rs7678949 chr4:185635018 G/C cg04058563 chr4:185651563 MLF1IP 0.73 9.38 0.46 1.13e-18 Blood protein levels; CRC cis rs4604732 0.631 rs76761880 chr1:247626377 T/A cg02104434 chr1:247694406 LOC148824;OR2C3 0.6 8.82 0.44 6.67e-17 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CRC cis rs35306767 0.623 rs36051896 chr10:1155747 T/C cg20503657 chr10:835505 NA 0.73 8.54 0.43 4.99e-16 Eosinophil percentage of granulocytes; CRC cis rs769267 0.930 rs7254748 chr19:19397479 A/C cg02546618 chr19:19431379 KIAA0892;SF4 0.46 6.35 0.33 7.02e-10 Tonsillectomy; CRC cis rs9503598 1.000 rs9503598 chr6:3446263 A/G cg00476032 chr6:3446245 SLC22A23 -0.42 -6.84 -0.35 3.88e-11 Cognitive ability (multi-trait analysis);Cognitive ability;Intelligence (multi-trait analysis); CRC cis rs4718428 0.705 rs3800817 chr7:66263550 T/A cg18252515 chr7:66147081 NA -0.51 -7.04 -0.36 1.16e-11 Corneal structure; CRC trans rs459571 0.715 rs401826 chr9:136890591 C/T cg15028160 chr19:49622717 PPFIA3;C19orf73 -0.58 -7.19 -0.37 4.46e-12 Platelet distribution width; CRC cis rs5769765 1.000 rs1033665 chr22:50252127 A/G cg04121214 chr22:50244548 NA 0.46 7.18 0.37 4.73e-12 Schizophrenia; CRC cis rs651907 0.557 rs34457525 chr3:101435225 C/T cg11279151 chr3:101281821 RG9MTD1 -0.55 -7.58 -0.39 3.52e-13 Colorectal cancer; CRC cis rs66573146 0.561 rs67245546 chr4:6947164 T/C cg26116260 chr4:7069785 GRPEL1 -0.66 -5.74 -0.3 2.13e-8 Granulocyte percentage of myeloid white cells; CRC cis rs10193935 0.901 rs997288 chr2:42525582 C/G cg27598129 chr2:42591480 NA -0.62 -7.45 -0.38 8.46e-13 Colonoscopy-negative controls vs population controls; CRC cis rs7113874 0.589 rs7939731 chr11:8510299 T/G cg20771178 chr11:8615675 STK33 -0.35 -5.75 -0.3 2.05e-8 Body mass index in physically active individuals;Body mass index (joint analysis main effects and physical activity interaction); CRC trans rs6600671 1.000 rs4844607 chr1:121184059 C/T cg00646200 chr1:148855367 NA -0.35 -6.53 -0.34 2.53e-10 Hip geometry; CRC cis rs9818758 0.607 rs11706052 chr3:49064110 A/G cg07636037 chr3:49044803 WDR6 -0.82 -6.7 -0.35 9.21e-11 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; CRC cis rs6502050 0.835 rs7221451 chr17:80089785 A/G cg22110888 chr17:80059540 CCDC57 0.41 6.39 0.33 5.57e-10 Life satisfaction; CRC cis rs3018066 0.867 rs7693333 chr4:107047594 A/C cg01869342 chr4:106983673 TBCK -0.37 -5.8 -0.3 1.58e-8 Cancer; CRC cis rs3858526 0.920 rs11039548 chr11:5930283 G/A cg02574844 chr11:5959923 NA -0.43 -6.11 -0.32 2.77e-9 DNA methylation (variation); CRC cis rs6534441 1.000 rs12651542 chr4:125419479 T/G cg21609808 chr4:125404261 NA -0.38 -5.76 -0.3 1.98e-8 Major depressive disorder; CRC cis rs9916302 0.808 rs12948906 chr17:37644854 C/T cg15445000 chr17:37608096 MED1 0.42 9.27 0.46 2.5e-18 Glomerular filtration rate (creatinine); CRC cis rs875971 0.862 rs801194 chr7:66028495 T/C cg12463550 chr7:65579703 CRCP -0.47 -6.4 -0.33 5.38e-10 Aortic root size; CRC cis rs4713118 0.662 rs9393881 chr6:28023751 C/G cg15845792 chr6:28175446 NA 0.92 13.04 0.58 1.34e-31 Parkinson's disease; CRC cis rs9818758 0.607 rs61729488 chr3:49067904 T/C cg07636037 chr3:49044803 WDR6 -0.82 -6.2 -0.32 1.68e-9 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; CRC cis rs3771570 1.000 rs3771564 chr2:242355701 G/A cg21155796 chr2:242212141 HDLBP 0.6 6.69 0.35 9.36e-11 Prostate cancer; CRC cis rs1577917 0.771 rs9450290 chr6:86233397 T/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A 0.66 8.73 0.43 1.35e-16 Response to antipsychotic treatment; CRC cis rs853679 0.517 rs9368550 chr6:28051803 T/A cg02631126 chr6:28058918 ZSCAN12L1 0.29 6.09 0.32 3.1e-9 Depression; CRC cis rs1552244 0.608 rs7615408 chr3:10000186 A/G cg08888203 chr3:10149979 C3orf24 0.49 7.57 0.39 3.85e-13 Alzheimer's disease; CRC cis rs6743226 0.748 rs12620606 chr2:242154015 A/G cg10021735 chr2:242295487 FARP2 0.43 6.21 0.32 1.58e-9 Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI in non-smokers; CRC trans rs2303319 0.504 rs56405014 chr2:162497603 C/T cg18122310 chr12:50236657 BCDIN3D -0.73 -6.13 -0.32 2.58e-9 Cognitive function; CRC cis rs13108904 0.870 rs13115355 chr4:1261576 G/A cg00684032 chr4:1343700 KIAA1530 0.46 6.76 0.35 6.27e-11 Obesity-related traits; CRC cis rs847577 0.572 rs847573 chr7:97681761 C/T cg24562669 chr7:97807699 LMTK2 -0.51 -7.77 -0.39 1.03e-13 Breast cancer; CRC trans rs2243480 1.000 rs7778911 chr7:65694506 T/C cg10756647 chr7:56101905 PSPH -0.79 -8.16 -0.41 7.21e-15 Diabetic kidney disease; CRC cis rs12476592 0.602 rs4671065 chr2:63791131 G/A cg10828910 chr2:63850056 LOC388955 0.49 6.11 0.32 2.79e-9 Childhood ear infection; CRC cis rs4663866 0.901 rs3739067 chr2:239184203 G/A cg16914508 chr2:239161102 PER2 0.74 7.35 0.38 1.56e-12 Irritable bowel syndrome; CRC trans rs2976388 0.647 rs2585154 chr8:143783485 C/T cg24628676 chr5:59189846 PDE4D -0.3 -5.96 -0.31 6.32e-9 Urinary tract infection frequency; CRC cis rs1997103 1.000 rs6953494 chr7:55412157 G/A cg17469321 chr7:55412551 NA 0.72 11.16 0.52 9.35e-25 QRS interval (sulfonylurea treatment interaction); CRC cis rs6973256 0.605 rs10227672 chr7:133326196 G/C cg10665199 chr7:133106180 EXOC4 -0.45 -7.09 -0.36 8.48e-12 Intelligence (multi-trait analysis); CRC cis rs3096299 0.685 rs4238830 chr16:89540241 C/T cg00750074 chr16:89608354 SPG7 -0.5 -7.68 -0.39 1.86e-13 Multiple myeloma (IgH translocation); CRC cis rs798554 0.644 rs7783400 chr7:2894434 A/C cg04166393 chr7:2884313 GNA12 -0.47 -6.65 -0.34 1.26e-10 Height; CRC trans rs10230207 0.647 rs985882 chr7:19575505 A/G cg03214765 chr19:55678215 C19orf51 0.46 6.3 0.33 9.3e-10 Intracranial aneurysm; CRC cis rs7542091 0.635 rs7550733 chr1:210044968 G/A cg22029157 chr1:209979665 IRF6 0.47 7.4 0.38 1.11e-12 Monobrow; CRC cis rs1044826 0.553 rs295469 chr3:139212900 G/A cg00490450 chr3:139108681 COPB2 0.44 6.46 0.34 3.84e-10 Obesity-related traits; CRC cis rs2067615 0.542 rs4964184 chr12:107070425 A/T cg13491945 chr12:107078410 RFX4 0.35 6.07 0.32 3.52e-9 Heart rate; CRC cis rs7666738 0.830 rs7664169 chr4:99037859 C/T cg17366294 chr4:99064904 C4orf37 -0.44 -7.38 -0.38 1.3e-12 Colonoscopy-negative controls vs population controls; CRC cis rs4713118 0.513 rs149941 chr6:28001033 T/C cg20615401 chr6:28092323 ZSCAN16 0.46 6.19 0.32 1.82e-9 Parkinson's disease; CRC cis rs9611565 0.918 rs2281333 chr22:41749630 T/C cg06634786 chr22:41940651 POLR3H -0.44 -6.02 -0.32 4.61e-9 Vitiligo; CRC cis rs9649213 0.593 rs7776638 chr7:97993506 C/T cg24562669 chr7:97807699 LMTK2 0.44 7.32 0.37 1.97e-12 Prostate cancer (SNP x SNP interaction); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg06396496 chr3:53289970 TKT 0.52 7.32 0.37 1.91e-12 Response to antipsychotic treatment; CRC cis rs6089584 0.526 rs6089316 chr20:60627552 C/T cg13770153 chr20:60521292 NA -0.44 -6.53 -0.34 2.43e-10 Body mass index; CRC cis rs66782572 1 rs66782572 chr3:52567617 A/G cg01758942 chr3:52551074 STAB1 0.32 6.31 0.33 9.19e-10 Hemoglobin concentration; CRC cis rs875971 0.862 rs13226170 chr7:65999298 G/A cg12463550 chr7:65579703 CRCP 0.47 6.43 0.33 4.41e-10 Aortic root size; CRC cis rs6424115 0.679 rs2267961 chr1:24071048 A/G cg15997130 chr1:24165203 NA -0.66 -8.31 -0.42 2.49e-15 Immature fraction of reticulocytes; CRC cis rs4819052 0.851 rs2838836 chr21:46665875 G/T cg11663144 chr21:46675770 NA -0.83 -14.13 -0.61 9.4e-36 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs11212617 1.000 rs608086 chr11:108185023 G/A cg12106634 chr11:108092400 ATM;NPAT 0.42 6.22 0.32 1.52e-9 Response to metformin in type 2 diabetes (glycemic); CRC cis rs28386778 0.830 rs7209321 chr17:61855668 A/C cg07362569 chr17:61921086 SMARCD2 0.38 5.7 0.3 2.66e-8 Prudent dietary pattern; CRC cis rs11098499 0.644 rs28787668 chr4:120554687 G/A cg09307838 chr4:120376055 NA 0.6 9.14 0.45 6.54e-18 Corneal astigmatism; CRC cis rs12928939 0.911 rs12919271 chr16:71792696 C/A cg08717414 chr16:71523259 ZNF19 -0.48 -5.93 -0.31 7.85e-9 Post bronchodilator FEV1; CRC cis rs1046896 0.512 rs3785513 chr17:80886748 G/A cg03160526 chr17:80928410 B3GNTL1 0.55 7.79 0.39 8.78e-14 Glycated hemoglobin levels; CRC cis rs7927771 0.864 rs2293577 chr11:47437202 C/T cg18512352 chr11:47633146 NA 0.36 7.1 0.36 7.8e-12 Subjective well-being; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg09435190 chr22:50968297 TYMP 0.39 6.0 0.31 5.11e-9 Liver disease severity in Alagille syndrome; CRC cis rs7666738 0.830 rs1426668 chr4:98945585 T/A cg17366294 chr4:99064904 C4orf37 0.43 7.34 0.38 1.69e-12 Colonoscopy-negative controls vs population controls; CRC cis rs10256972 0.641 rs12702017 chr7:1129413 C/T cg07308232 chr7:1071921 C7orf50 -0.44 -6.0 -0.31 5.17e-9 Longevity;Endometriosis; CRC trans rs9929218 0.529 rs8060790 chr16:68729112 A/G cg04657470 chr2:198365150 HSPE1;HSPD1 1.07 21.9 0.77 3.14e-66 Colorectal cancer; CRC cis rs9828933 0.766 rs704361 chr3:63883671 T/G cg16258503 chr3:63850278 ATXN7;THOC7 0.67 6.91 0.36 2.51e-11 Type 2 diabetes; CRC cis rs4713118 0.539 rs510987 chr6:27847517 G/A cg03623178 chr6:28175578 NA 0.75 10.59 0.5 9.61e-23 Parkinson's disease; CRC cis rs703842 0.964 rs2014886 chr12:58177437 C/T cg00677455 chr12:58241039 CTDSP2 0.64 8.66 0.43 2.14e-16 Multiple sclerosis; CRC trans rs3733585 0.604 rs73215003 chr4:10126317 C/G cg26043149 chr18:55253948 FECH -0.57 -8.28 -0.42 3.22e-15 Cleft plate (environmental tobacco smoke interaction); CRC cis rs2050392 0.929 rs10826798 chr10:30700904 G/A cg18806716 chr10:30721971 MAP3K8 0.47 7.22 0.37 3.6e-12 Inflammatory bowel disease; CRC trans rs877282 0.898 rs11253341 chr10:765008 G/C cg22713356 chr15:30763199 NA 1.29 15.31 0.65 2.44e-40 Uric acid levels; CRC cis rs7224685 0.569 rs2123841 chr17:4022557 G/C cg05562828 chr17:3906858 NA 0.46 5.96 0.31 6.33e-9 Type 2 diabetes; CRC cis rs6951245 1.000 rs11770909 chr7:1086716 G/A cg22907277 chr7:1156413 C7orf50 0.71 7.23 0.37 3.5e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC trans rs1814175 0.645 rs10742953 chr11:49807491 C/G cg15704280 chr7:45808275 SEPT13 0.96 16.38 0.67 1.56e-44 Height; CRC cis rs25645 0.792 rs8077456 chr17:38128765 C/G cg17344932 chr17:38183730 MED24;SNORD124 0.72 13.1 0.59 7.36e-32 Myeloid white cell count; CRC trans rs1455244 0.700 rs7229302 chr18:11508904 G/T cg11717700 chr4:154387421 KIAA0922 0.38 6.02 0.31 4.7e-9 Schizophrenia; CRC cis rs6662572 0.737 rs1355641 chr1:46599143 T/A cg08644498 chr1:46502608 NA 0.44 6.99 0.36 1.57e-11 Blood protein levels; CRC cis rs2932538 0.922 rs4838961 chr1:113163967 T/C cg22162597 chr1:113214053 CAPZA1 -0.72 -10.35 -0.5 6.43e-22 Systolic blood pressure;Diastolic blood pressure;Hypertension;Blood pressure; CRC cis rs7916697 0.947 rs1900004 chr10:70000881 C/T cg06988349 chr10:69991859 ATOH7 0.34 6.18 0.32 1.87e-9 Optic disc area; CRC cis rs10504229 0.683 rs11786074 chr8:58133532 A/G cg05313129 chr8:58192883 C8orf71 -0.43 -6.11 -0.32 2.74e-9 Developmental language disorder (linguistic errors); CRC cis rs12681287 0.673 rs2976178 chr8:87332552 C/G cg27223183 chr8:87520930 FAM82B -0.48 -6.33 -0.33 8.23e-10 Caudate activity during reward; CRC cis rs780096 0.546 rs715326 chr2:27725761 A/G cg12648201 chr2:27665141 KRTCAP3 0.29 5.78 0.3 1.69e-8 Total body bone mineral density; CRC cis rs477895 0.838 rs11607007 chr11:64007976 C/T cg05016508 chr11:63871570 FLRT1;MACROD1 0.53 6.52 0.34 2.71e-10 Mean platelet volume; CRC cis rs7666738 0.830 rs6848397 chr4:98946738 A/G cg17366294 chr4:99064904 C4orf37 0.43 7.34 0.38 1.69e-12 Colonoscopy-negative controls vs population controls; CRC cis rs9611519 0.929 rs11090039 chr22:41496800 G/A cg03806693 chr22:41940476 POLR3H -0.65 -7.94 -0.4 3.31e-14 Neuroticism; CRC cis rs3845702 0.935 rs6433822 chr2:180840422 G/C cg23417306 chr2:180868811 CWC22 -0.45 -6.09 -0.32 3.1e-9 Schizophrenia; CRC cis rs10504229 0.679 rs72649107 chr8:58030453 C/A cg02725872 chr8:58115012 NA -0.37 -6.64 -0.34 1.29e-10 Developmental language disorder (linguistic errors); CRC cis rs4319547 0.737 rs10846921 chr12:122943376 G/T cg23029597 chr12:123009494 RSRC2 0.47 6.14 0.32 2.37e-9 Body mass index; CRC cis rs4722166 0.695 rs4722177 chr7:22798531 T/C cg26061582 chr7:22766209 IL6 0.51 8.04 0.41 1.66e-14 Lung cancer; CRC cis rs853679 1.000 rs735765 chr6:28170297 G/A cg25164649 chr6:28176230 NA 0.62 5.91 0.31 8.41e-9 Depression; CRC cis rs4664293 0.867 rs13432 chr2:160625727 C/G cg08347373 chr2:160653686 CD302 -0.49 -7.7 -0.39 1.64e-13 Monocyte percentage of white cells; CRC cis rs7586879 1.000 rs10175064 chr2:25117537 T/C cg04586622 chr2:25135609 ADCY3 -0.43 -7.19 -0.37 4.46e-12 Body mass index; CRC trans rs3806843 0.801 rs801170 chr5:140115343 C/T cg06840491 chr10:48416966 GDF2 -0.35 -6.18 -0.32 1.88e-9 Depressive symptoms (multi-trait analysis); CRC cis rs1443512 0.812 rs1975472 chr12:54337083 A/G cg17410650 chr12:54324560 NA -0.34 -6.14 -0.32 2.38e-9 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for BMI in non-smokers;Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction);Waist-hip ratio;Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour); CRC trans rs10242455 0.702 rs73397481 chr7:99030108 C/T cg09045935 chr12:6379348 NA 1.18 9.09 0.45 9.34e-18 Blood metabolite levels; CRC cis rs1008375 1.000 rs11727312 chr4:17669185 C/T cg04450456 chr4:17643702 FAM184B 0.37 5.87 0.31 1.08e-8 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs9660180 0.967 rs11260623 chr1:1781456 G/T cg23982607 chr1:1823379 GNB1 -0.91 -16.71 -0.68 7.93e-46 Body mass index; CRC cis rs6460942 1.000 rs17191008 chr7:12417690 T/G cg20607287 chr7:12443886 VWDE -0.64 -6.38 -0.33 6.05e-10 Coronary artery disease; CRC cis rs4604732 0.631 rs35046441 chr1:247626812 G/A cg02104434 chr1:247694406 LOC148824;OR2C3 0.6 8.82 0.44 6.67e-17 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CRC cis rs6460942 0.687 rs74753576 chr7:12463926 G/A cg06484146 chr7:12443880 VWDE -0.69 -8.55 -0.43 4.81e-16 Coronary artery disease; CRC trans rs875971 0.660 rs2191268 chr7:66110224 C/T cg02281226 chr17:9479218 STX8;WDR16 -0.41 -6.75 -0.35 6.8e-11 Aortic root size; CRC cis rs172166 0.516 rs1150670 chr6:28130559 A/G cg25164649 chr6:28176230 NA 0.47 6.95 0.36 2e-11 Cardiac Troponin-T levels; CRC cis rs7208859 0.623 rs8068645 chr17:29104342 T/A cg13385521 chr17:29058706 SUZ12P 0.74 8.39 0.42 1.47e-15 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs713587 0.719 rs58048722 chr2:25187825 C/T cg22495460 chr2:25135724 ADCY3 0.66 11.01 0.52 3.24e-24 Body mass index in non-asthmatics; CRC cis rs7078219 0.543 rs10786557 chr10:101283328 C/G cg09788492 chr10:101292477 NKX2-3 0.28 5.64 0.3 3.67e-8 Dental caries; CRC cis rs6460942 0.915 rs1595802 chr7:12439672 C/T cg20607287 chr7:12443886 VWDE -0.68 -7.33 -0.37 1.84e-12 Coronary artery disease; CRC cis rs35883536 0.588 rs955337 chr1:101108834 A/T cg14515779 chr1:101123966 NA -0.35 -6.18 -0.32 1.95e-9 Monocyte count; CRC trans rs67340775 0.541 rs200964 chr6:27866943 G/C cg06606381 chr12:133084897 FBRSL1 -0.64 -6.35 -0.33 7.24e-10 Lung cancer in ever smokers; CRC cis rs2439831 0.850 rs28413704 chr15:44148427 A/G cg02155558 chr15:43621948 ADAL;LCMT2 0.69 7.39 0.38 1.19e-12 Lung cancer in ever smokers; CRC cis rs6840360 0.642 rs7658169 chr4:152353414 G/A cg09659197 chr4:152720779 NA 0.33 6.59 0.34 1.7e-10 Intelligence (multi-trait analysis); CRC cis rs3796619 1.000 rs28620427 chr4:1086247 T/G cg27284194 chr4:1044797 NA 0.41 6.39 0.33 5.7e-10 Recombination rate (males); CRC cis rs6424115 0.830 rs2229585 chr1:24200921 T/C cg15997130 chr1:24165203 NA 0.73 10.74 0.51 2.79e-23 Immature fraction of reticulocytes; CRC cis rs853679 0.517 rs9368552 chr6:28068426 A/G cg18032046 chr6:28092343 ZSCAN16 -0.5 -5.89 -0.31 9.34e-9 Depression; CRC cis rs600806 0.850 rs10745355 chr1:109951711 T/C cg23032129 chr1:109941072 SORT1 -0.28 -5.94 -0.31 7.09e-9 Intelligence (multi-trait analysis); CRC cis rs765787 0.530 rs1706831 chr15:45516230 T/C cg24006582 chr15:45444508 DUOX1 -0.57 -8.75 -0.43 1.15e-16 Uric acid levels; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg08517826 chr3:33759932 CLASP2 -0.42 -6.27 -0.33 1.15e-9 Liver disease severity in Alagille syndrome; CRC cis rs972578 0.967 rs4822236 chr22:43358088 A/G cg01576275 chr22:43409880 NA -0.45 -7.25 -0.37 3.08e-12 Mean platelet volume; CRC cis rs2839186 0.900 rs56840278 chr21:47708933 T/G cg09417038 chr21:47716443 C21orf57 -0.42 -6.93 -0.36 2.21e-11 Testicular germ cell tumor; CRC cis rs12134245 0.742 rs17501381 chr1:92003919 A/G cg02896835 chr1:92012615 NA -0.65 -11.58 -0.54 2.98e-26 Breast cancer; CRC cis rs10888329 0.741 rs6587438 chr1:248355881 G/C cg00666640 chr1:248458726 OR2T12 0.44 6.97 0.36 1.75e-11 Autism spectrum disorder; CRC cis rs2072510 1.000 rs1978331 chr12:96409201 A/G cg22491680 chr12:96389547 HAL -0.37 -5.88 -0.31 9.99e-9 Metabolite levels (small molecules and protein measures); CRC cis rs6831352 0.840 rs29001223 chr4:100047433 C/T cg12011299 chr4:100065546 ADH4 -0.49 -9.25 -0.45 3.02e-18 Alcohol dependence; CRC cis rs644799 0.965 rs10831426 chr11:95505888 G/A cg03916912 chr11:95522834 CEP57;FAM76B 0.96 17.82 0.7 3.44e-50 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs10992471 0.603 rs747628 chr9:95289532 A/T cg14631576 chr9:95140430 CENPP -0.39 -6.77 -0.35 5.99e-11 Visceral adipose tissue/subcutaneous adipose tissue ratio; CRC cis rs9682041 1.000 rs15709 chr3:170110529 T/A cg11886554 chr3:170076028 SKIL 0.74 8.28 0.42 3.11e-15 Glomerular filtration rate in non diabetics (creatinine);Glomerular filtration rate (creatinine); CRC cis rs7617773 0.780 rs11714176 chr3:48360862 C/T cg11946769 chr3:48343235 NME6 0.73 9.9 0.48 2.16e-20 Coronary artery disease; CRC cis rs5769765 0.773 rs9616208 chr22:50313359 G/A cg04121214 chr22:50244548 NA 0.42 5.95 0.31 6.94e-9 Schizophrenia; CRC cis rs1215050 0.740 rs13134479 chr4:99067723 G/A cg05340658 chr4:99064831 C4orf37 0.49 7.33 0.37 1.78e-12 Waist-to-hip ratio adjusted for body mass index; CRC cis rs172166 0.516 rs1225715 chr6:28113373 C/T cg02683197 chr6:28174875 NA -0.44 -6.1 -0.32 2.92e-9 Cardiac Troponin-T levels; CRC cis rs13118159 0.742 rs34947293 chr4:1335034 T/C cg02018176 chr4:1364513 KIAA1530 0.4 6.59 0.34 1.79e-10 Longevity; CRC cis rs1215050 0.791 rs1215049 chr4:98848280 C/T cg05340658 chr4:99064831 C4orf37 0.49 7.24 0.37 3.28e-12 Waist-to-hip ratio adjusted for body mass index; CRC cis rs4713675 0.584 rs6457739 chr6:33673831 A/G cg14003231 chr6:33640908 ITPR3 0.51 8.26 0.41 3.71e-15 Plateletcrit; CRC cis rs10760158 0.832 rs3827678 chr9:124046722 C/T cg14417974 chr9:124058376 GSN -0.34 -5.8 -0.3 1.57e-8 Pulse pressure; CRC cis rs10779751 1.000 rs7549109 chr1:11278813 C/G cg08854313 chr1:11322531 MTOR -0.77 -12.04 -0.55 6.75e-28 Body mass index; CRC trans rs9650657 0.585 rs4841401 chr8:10489592 C/G cg06636001 chr8:8085503 FLJ10661 -0.57 -8.09 -0.41 1.14e-14 Neuroticism; CRC cis rs6598955 0.694 rs4659416 chr1:26580937 T/G cg00852783 chr1:26633632 UBXN11 0.43 7.1 0.36 7.77e-12 Obesity-related traits; CRC cis rs9911578 1.000 rs437732 chr17:56675861 A/C cg05425664 chr17:57184151 TRIM37 -0.5 -7.98 -0.4 2.38e-14 Intelligence (multi-trait analysis); CRC cis rs7647973 0.580 rs2334958 chr3:49252364 C/T cg20833759 chr3:49053208 WDR6;DALRD3 0.39 6.49 0.34 3.14e-10 Menarche (age at onset); CRC cis rs995000 0.899 rs11577840 chr1:62991369 T/C cg19896129 chr1:63156450 NA -0.45 -6.94 -0.36 2.07e-11 Triglyceride levels; CRC cis rs10504229 0.639 rs56066782 chr8:58105857 A/G cg24829409 chr8:58192753 C8orf71 -0.56 -8.01 -0.4 2.05e-14 Developmental language disorder (linguistic errors); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg24513433 chr18:47088234 LIPG 0.39 6.26 0.33 1.2e-9 Liver disease severity in Alagille syndrome; CRC cis rs1559088 0.600 rs6510344 chr19:33583942 C/A cg17764715 chr19:33622953 WDR88 0.45 6.52 0.34 2.63e-10 Bone ultrasound measurement (broadband ultrasound attenuation); CRC cis rs7739232 0.920 rs74447887 chr6:53529219 A/G cg15658676 chr6:53530538 KLHL31 -0.76 -5.9 -0.31 8.9e-9 Hip circumference adjusted for BMI; CRC cis rs644799 1.000 rs693597 chr11:95589629 T/C cg25478527 chr11:95522999 CEP57;FAM76B 0.53 8.0 0.4 2.17e-14 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs1577917 1.000 rs2816815 chr6:86691656 C/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.51 -6.89 -0.36 2.82e-11 Response to antipsychotic treatment; CRC cis rs9309711 0.770 rs13409323 chr2:3488184 C/T cg10845886 chr2:3471009 TTC15 -0.69 -10.89 -0.51 8.35e-24 Neurofibrillary tangles; CRC cis rs826838 0.616 rs4619214 chr12:38614704 C/A cg26384229 chr12:38710491 ALG10B 0.43 6.25 0.33 1.26e-9 Heart rate; CRC cis rs7615952 0.641 rs66520539 chr3:125780374 G/A cg18479299 chr3:125709523 NA -0.55 -6.58 -0.34 1.86e-10 Blood pressure (smoking interaction); CRC cis rs644799 1.000 rs3748256 chr11:95521953 A/G cg25478527 chr11:95522999 CEP57;FAM76B 0.52 7.76 0.39 1.09e-13 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs877282 0.945 rs11253391 chr10:788752 G/A cg17470449 chr10:769945 NA 0.69 9.03 0.45 1.51e-17 Uric acid levels; CRC cis rs8060686 0.925 rs1134760 chr16:67964203 T/C cg26727032 chr16:67993705 SLC12A4 -0.63 -9.54 -0.47 3.46e-19 HDL cholesterol;Metabolic syndrome; CRC cis rs6743376 0.533 rs10206428 chr2:113826475 A/G cg24553058 chr2:113831203 IL1F10 0.35 5.83 0.31 1.32e-8 Inflammatory biomarkers; CRC cis rs12410462 1.000 rs1587158 chr1:227658753 G/A cg23173402 chr1:227635558 NA -0.58 -6.72 -0.35 7.93e-11 Major depressive disorder; CRC cis rs10256972 0.568 rs1133043 chr7:1133305 C/G cg04025307 chr7:1156635 C7orf50 0.76 12.66 0.57 3.25e-30 Longevity;Endometriosis; CRC cis rs6951245 1.000 rs79443843 chr7:1075245 G/A cg21664854 chr7:1097933 C7orf50;GPR146 0.79 8.97 0.44 2.23e-17 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs73206853 0.841 rs73206847 chr12:110672353 G/A cg12870014 chr12:110450643 ANKRD13A 0.8 7.8 0.39 8.42e-14 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC cis rs11098499 0.562 rs2389879 chr4:120557684 G/A cg24375607 chr4:120327624 NA -0.4 -6.33 -0.33 8.23e-10 Corneal astigmatism; CRC cis rs7619708 1 rs7619708 chr3:195810187 T/C cg01181863 chr3:195395398 SDHAP2 0.55 6.46 0.34 3.66e-10 Red cell distribution width; CRC cis rs7666738 0.611 rs34982650 chr4:98819530 T/A cg05340658 chr4:99064831 C4orf37 0.54 7.74 0.39 1.19e-13 Colonoscopy-negative controls vs population controls; CRC cis rs2415984 0.622 rs11846013 chr14:46932291 A/C cg14871534 chr14:47121158 RPL10L 0.43 6.29 0.33 1.04e-9 Number of children ever born; CRC cis rs2882667 0.931 rs12719518 chr5:138340976 T/C cg09476006 chr5:138032270 NA 0.44 7.32 0.37 1.97e-12 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs8180040 0.966 rs59586735 chr3:47518325 C/T cg10298567 chr3:47292165 KIF9 0.38 6.09 0.32 3.06e-9 Colorectal cancer; CRC cis rs4268898 0.722 rs10445893 chr2:24407128 A/G cg26838691 chr2:24397539 C2orf84 0.4 5.66 0.3 3.22e-8 Asthma; CRC cis rs7927771 0.832 rs4992357 chr11:47393638 C/T cg05585544 chr11:47624801 NA -0.47 -8.25 -0.41 3.78e-15 Subjective well-being; CRC cis rs7633770 0.786 rs1520489 chr3:46677519 A/G cg11219411 chr3:46661640 NA -0.55 -8.94 -0.44 2.78e-17 Coronary artery disease; CRC cis rs6860806 0.507 rs169256 chr5:131688533 A/G cg12564285 chr5:131593104 PDLIM4 0.43 6.31 0.33 9.06e-10 Breast cancer; CRC trans rs1376359 0.636 rs7536383 chr1:103123803 C/A cg16220183 chr17:56609687 SEPT4 -0.47 -6.48 -0.34 3.34e-10 QRS duration in Tripanosoma cruzi seropositivity; CRC cis rs7666738 0.830 rs1426664 chr4:98988264 A/C cg17366294 chr4:99064904 C4orf37 0.43 7.33 0.37 1.76e-12 Colonoscopy-negative controls vs population controls; CRC cis rs3812762 0.701 rs4929915 chr11:8824418 A/C cg21881798 chr11:8931708 C11orf17;ST5 -0.44 -5.77 -0.3 1.86e-8 Hypospadias; CRC trans rs2303319 0.504 rs72877343 chr2:162607487 A/C cg10498984 chr16:28874827 SH2B1 -0.73 -6.3 -0.33 9.75e-10 Cognitive function; CRC cis rs2832191 0.791 rs2832181 chr21:30481371 G/T cg24692254 chr21:30365293 RNF160 -0.71 -12.4 -0.56 3.17e-29 Dental caries; CRC cis rs875971 0.862 rs4236208 chr7:65749078 C/T cg18252515 chr7:66147081 NA 0.39 5.72 0.3 2.45e-8 Aortic root size; CRC cis rs7811142 1.000 rs74460138 chr7:100027339 C/G cg00814883 chr7:100076585 TSC22D4 -0.74 -9.42 -0.46 8.21e-19 Platelet count; CRC cis rs9322193 0.923 rs9767652 chr6:150055638 A/T cg00933542 chr6:150070202 PCMT1 0.31 6.19 0.32 1.8e-9 Lung cancer; CRC cis rs7666738 0.791 rs34152299 chr4:98929862 G/C cg05340658 chr4:99064831 C4orf37 0.6 9.35 0.46 1.41e-18 Colonoscopy-negative controls vs population controls; CRC cis rs11098499 0.722 rs28713555 chr4:120251995 C/T cg24375607 chr4:120327624 NA 0.47 7.6 0.39 3.06e-13 Corneal astigmatism; CRC cis rs10911251 0.546 rs3359 chr1:183112041 G/C ch.1.3577855R chr1:183094577 LAMC1 0.8 13.59 0.6 1.06e-33 Colorectal cancer; CRC cis rs8180040 0.764 rs11130115 chr3:47181661 C/A cg10298567 chr3:47292165 KIF9 -0.36 -5.77 -0.3 1.8e-8 Colorectal cancer; CRC cis rs72781680 0.611 rs72781692 chr2:24263319 T/G cg20701182 chr2:24300061 SF3B14 0.63 6.99 0.36 1.58e-11 Lymphocyte counts; CRC cis rs34779708 0.931 rs7923172 chr10:35309367 G/A cg03585969 chr10:35415529 CREM 0.59 7.86 0.4 5.38e-14 Inflammatory bowel disease;Crohn's disease; CRC cis rs11579220 1 rs11579220 chr1:205144363 G/T cg03948781 chr1:205179583 DSTYK 0.43 5.94 0.31 7.43e-9 White blood cell count (basophil);Basophil percentage of white cells; CRC cis rs6840360 0.615 rs4696290 chr4:152631472 A/G cg09659197 chr4:152720779 NA 0.4 8.26 0.41 3.7e-15 Intelligence (multi-trait analysis); CRC cis rs6918586 0.616 rs1056314 chr6:26114653 G/A cg18357526 chr6:26021779 HIST1H4A 0.49 7.39 0.38 1.21e-12 Schizophrenia; CRC cis rs9560113 0.960 rs4773378 chr13:112174154 G/A cg14154082 chr13:112174009 NA 0.35 5.71 0.3 2.59e-8 Menarche (age at onset); CRC cis rs7833986 1.000 rs66553445 chr8:57096781 G/A cg23139584 chr8:56987506 RPS20;SNORD54 0.61 7.54 0.38 4.64e-13 Height; CRC cis rs6604026 0.922 rs71652510 chr1:93366357 T/C cg22128645 chr1:93425802 FAM69A -0.4 -5.86 -0.31 1.15e-8 Multiple sclerosis; CRC cis rs755249 0.567 rs61779309 chr1:39940499 T/C cg18385671 chr1:39797026 MACF1 -0.41 -5.67 -0.3 3.1e-8 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs11622475 1.000 rs1187448 chr14:104406627 C/T cg12183467 chr14:104352244 NA -0.47 -6.76 -0.35 6.16e-11 Bipolar disorder; CRC cis rs4563143 0.663 rs2218396 chr19:29236392 C/T cg04546413 chr19:29218101 NA 0.4 6.18 0.32 1.84e-9 Methadone dose in opioid dependence; CRC cis rs2404602 0.716 rs12907805 chr15:76690606 C/T cg22467129 chr15:76604101 ETFA -0.43 -7.15 -0.37 5.5e-12 Blood metabolite levels; CRC cis rs4731207 0.596 rs1481332 chr7:124577262 G/T cg23710748 chr7:124431027 NA -0.39 -6.12 -0.32 2.67e-9 Cutaneous malignant melanoma; CRC cis rs826838 0.967 rs2892410 chr12:38990282 A/G cg26384229 chr12:38710491 ALG10B -0.73 -10.28 -0.49 1.12e-21 Heart rate; CRC cis rs1580019 0.563 rs13225132 chr7:32800975 A/G cg14728415 chr7:32535168 LSM5;AVL9 0.44 5.99 0.31 5.36e-9 Cognitive ability; CRC cis rs9488822 0.676 rs7774952 chr6:116380909 A/G cg05304507 chr6:116381966 FRK 0.29 7.96 0.4 2.91e-14 Cholesterol, total;LDL cholesterol; CRC trans rs7615952 0.546 rs11718647 chr3:125352022 G/A cg07211511 chr3:129823064 LOC729375 -0.59 -6.97 -0.36 1.74e-11 Blood pressure (smoking interaction); CRC cis rs9296092 0.500 rs9469504 chr6:33527243 G/A cg13560919 chr6:33536144 NA -0.44 -6.28 -0.33 1.09e-9 Age at smoking initiation in chronic obstructive pulmonary disease; CRC cis rs7119 0.717 rs62007348 chr15:77804501 C/T cg27398640 chr15:77910606 LINGO1 -0.46 -8.05 -0.41 1.5e-14 Type 2 diabetes; CRC cis rs6088580 0.634 rs6059890 chr20:33101653 G/C cg08999081 chr20:33150536 PIGU 0.64 11.83 0.55 3.91e-27 Glomerular filtration rate (creatinine); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg23629415 chr14:54955474 GMFB 0.44 6.26 0.33 1.2e-9 Response to antipsychotic treatment; CRC trans rs208520 0.837 rs208471 chr6:66916749 A/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.91 -11.82 -0.55 3.98e-27 Exhaled nitric oxide output; CRC cis rs720844 1.000 rs10454124 chr2:149345749 A/G cg09247360 chr2:149335327 NA -0.63 -7.73 -0.39 1.3e-13 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs35306767 0.668 rs35657988 chr10:1103590 A/G cg26597838 chr10:835615 NA 0.6 7.94 0.4 3.15e-14 Eosinophil percentage of granulocytes; CRC cis rs12474201 0.963 rs3829835 chr2:46925789 C/T cg06386533 chr2:46925753 SOCS5 0.81 13.37 0.59 7.47e-33 Height; CRC trans rs4942242 1.000 rs7335094 chr13:44223936 T/C cg26741380 chr15:41871084 TYRO3 -0.41 -6.22 -0.32 1.49e-9 Response to tocilizumab in rheumatoid arthritis; CRC trans rs7819412 0.595 rs10503416 chr8:10987553 C/T cg06636001 chr8:8085503 FLJ10661 0.48 7.3 0.37 2.17e-12 Triglycerides; CRC cis rs823143 0.570 rs823082 chr1:205786935 C/T cg14159672 chr1:205819179 PM20D1 -0.64 -9.77 -0.47 5.83e-20 Monocyte percentage of white cells; CRC cis rs8072100 0.840 rs1912482 chr17:45454883 G/A cg25173405 chr17:45401733 C17orf57 -0.52 -8.31 -0.42 2.61e-15 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs11601602 0.576 rs4075635 chr11:28511643 A/G cg06544937 chr11:28130018 METT5D1;KIF18A 0.59 7.92 0.4 3.63e-14 Obesity-related traits; CRC cis rs7715806 0.500 rs17649350 chr5:75006156 C/T cg19683494 chr5:74908142 NA -0.55 -6.42 -0.33 4.69e-10 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs2836974 0.666 rs35182074 chr21:40685284 A/C cg11890956 chr21:40555474 PSMG1 -0.88 -14.09 -0.61 1.3e-35 Cognitive function; CRC cis rs881375 1.000 rs6478486 chr9:123655329 T/C cg14255062 chr9:123606675 PSMD5;LOC253039 0.42 6.08 0.32 3.27e-9 Rheumatoid arthritis; CRC cis rs4654899 0.802 rs10916906 chr1:21255675 C/A cg02927042 chr1:21476669 EIF4G3 -0.5 -7.82 -0.4 7.31e-14 Superior frontal gyrus grey matter volume; CRC cis rs7945705 0.967 rs10840148 chr11:8923528 C/T cg12365402 chr11:9010492 NRIP3 0.49 7.94 0.4 3.15e-14 Hemoglobin concentration; CRC cis rs6860806 0.507 rs273912 chr5:131661349 A/C cg18301423 chr5:131593218 PDLIM4 -0.38 -6.34 -0.33 7.76e-10 Breast cancer; CRC cis rs9894429 0.505 rs35570626 chr17:79611084 A/G cg18240062 chr17:79603768 NPLOC4 0.48 7.55 0.38 4.24e-13 Eye color traits; CRC cis rs12760731 0.565 rs12040475 chr1:178185651 G/A cg00404053 chr1:178313656 RASAL2 1.11 11.47 0.53 7.73e-26 Obesity-related traits; CRC cis rs56114371 0.530 rs9357045 chr6:27688927 G/A cg19041857 chr6:27730383 NA -0.49 -6.28 -0.33 1.09e-9 Breast cancer; CRC cis rs2120019 0.938 rs2304903 chr15:75315778 A/G cg17294928 chr15:75287854 SCAMP5 -0.77 -11.09 -0.52 1.73e-24 Blood trace element (Zn levels); CRC trans rs2228479 0.850 rs11640188 chr16:89807732 C/T cg21302420 chr1:112162376 RAP1A 0.72 5.96 0.31 6.38e-9 Skin colour saturation; CRC cis rs76993477 0.666 rs75007377 chr1:169714267 G/A cg03211132 chr1:169703751 SELE 0.58 5.7 0.3 2.72e-8 Tonsillectomy; CRC cis rs4930103 0.591 rs11042048 chr11:1986240 C/G cg23202291 chr11:1979235 NA 0.63 9.2 0.45 4.34e-18 DNA methylation (parent-of-origin);DNA methylation (variation); CRC trans rs853679 0.607 rs201002 chr6:27808192 A/G cg06606381 chr12:133084897 FBRSL1 -0.74 -6.59 -0.34 1.72e-10 Depression; CRC cis rs6951245 1.000 rs74369356 chr7:1071711 T/C cg20603222 chr7:1096387 C7orf50;GPR146 -0.69 -8.1 -0.41 1.07e-14 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs4665809 1.000 rs4665811 chr2:26260017 A/G cg22920501 chr2:26401640 FAM59B -0.52 -7.11 -0.36 7.36e-12 Gut microbiome composition (summer); CRC cis rs10504229 0.683 rs16921823 chr8:58108612 G/C cg04204079 chr8:58130323 NA -0.46 -5.8 -0.3 1.58e-8 Developmental language disorder (linguistic errors); CRC cis rs79387448 0.745 rs76746266 chr2:103124920 C/T cg09003973 chr2:102972529 NA 0.68 7.54 0.38 4.74e-13 Gut microbiota (bacterial taxa); CRC cis rs72945132 0.882 rs6592552 chr11:70223831 A/T cg00319359 chr11:70116639 PPFIA1 0.56 6.34 0.33 7.73e-10 Coronary artery disease; CRC cis rs8044995 0.563 rs7190134 chr16:68381516 A/G cg05110241 chr16:68378359 PRMT7 0.76 7.69 0.39 1.66e-13 Schizophrenia; CRC cis rs60871478 0.947 rs62432862 chr7:807719 G/C cg13844804 chr7:814759 HEATR2 0.67 8.51 0.42 6.32e-16 Cerebrospinal P-tau181p levels; CRC cis rs7786808 0.608 rs6978352 chr7:158209802 T/C cg01191920 chr7:158217561 PTPRN2 0.59 9.5 0.46 4.4e-19 Obesity-related traits; CRC cis rs9381040 0.655 rs6903444 chr6:41014220 C/T cg04346459 chr6:41068666 NFYA;LOC221442 0.42 6.04 0.32 4.25e-9 Alzheimer's disease (late onset); CRC cis rs9660180 0.967 rs6603802 chr1:1812521 C/T cg13866156 chr1:1669148 SLC35E2 -0.62 -9.53 -0.47 3.6e-19 Body mass index; CRC cis rs9894429 1.000 rs7213129 chr17:79581573 C/T cg21028142 chr17:79581711 NPLOC4 0.39 8.62 0.43 2.89e-16 Eye color traits; CRC cis rs7666738 0.830 rs7672720 chr4:98938760 A/T cg05340658 chr4:99064831 C4orf37 0.59 9.25 0.45 2.92e-18 Colonoscopy-negative controls vs population controls; CRC cis rs6539267 0.847 rs12831519 chr12:106682917 A/G cg00173435 chr12:106696525 TCP11L2 0.51 6.03 0.32 4.35e-9 Tourette syndrome; CRC cis rs9393692 0.905 rs2393592 chr6:26285560 A/G cg00631329 chr6:26305371 NA -0.69 -13.71 -0.6 3.87e-34 Educational attainment; CRC cis rs1008375 1.000 rs4235388 chr4:17682030 G/A cg16339924 chr4:17578868 LAP3 0.51 6.66 0.34 1.17e-10 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs7249142 0.549 rs72997174 chr19:19294389 T/C cg12558012 chr19:19281197 LOC729991-MEF2B;MEF2B 0.59 9.07 0.45 1.14e-17 IgG glycosylation; CRC trans rs948562 1.000 rs76435840 chr11:58285981 G/T cg26660744 chr1:1573181 CDK11B 0.52 6.1 0.32 2.93e-9 Lymphoma; CRC cis rs6500395 1.000 rs7197732 chr16:48575878 G/A cg04672837 chr16:48644449 N4BP1 0.42 6.04 0.32 4.07e-9 Response to tocilizumab in rheumatoid arthritis; CRC cis rs2404602 0.716 rs12437627 chr15:76845050 T/C cg03037974 chr15:76606532 NA 0.71 12.66 0.57 3.3e-30 Blood metabolite levels; CRC cis rs1451375 0.583 rs3779078 chr7:50610918 C/T cg18232548 chr7:50535776 DDC 0.46 6.01 0.31 4.99e-9 Malaria; CRC cis rs6860806 0.507 rs272883 chr5:131668698 A/G cg18758796 chr5:131593413 PDLIM4 0.39 6.35 0.33 7.24e-10 Breast cancer; CRC cis rs1322512 1.000 rs2758785 chr6:153010878 C/T cg03415253 chr6:152958462 SYNE1 0.42 6.51 0.34 2.85e-10 Tonometry; CRC cis rs8177253 1.000 rs8177248 chr3:133479626 C/T cg24879335 chr3:133465180 TF 0.31 5.62 0.3 4.03e-8 Iron status biomarkers; CRC cis rs10256972 0.591 rs11766651 chr7:1161646 A/G cg22907277 chr7:1156413 C7orf50 0.67 10.27 0.49 1.23e-21 Longevity;Endometriosis; CRC cis rs4588572 0.643 rs10043027 chr5:77792707 T/C cg11547950 chr5:77652471 NA -0.57 -8.08 -0.41 1.21e-14 Triglycerides; CRC cis rs870825 0.929 rs1405939 chr4:185591444 C/T cg04058563 chr4:185651563 MLF1IP 0.57 5.61 0.3 4.24e-8 Blood protein levels; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg07552157 chr3:142720316 SR140 0.39 6.26 0.33 1.17e-9 Liver disease severity in Alagille syndrome; CRC cis rs477692 0.673 rs1970197 chr10:131359588 C/T cg05714579 chr10:131428358 MGMT 0.47 6.71 0.35 8.65e-11 Response to temozolomide; CRC cis rs6942756 0.876 rs822039 chr7:129065774 A/G cg02491457 chr7:128862824 NA -0.59 -7.96 -0.4 2.89e-14 White matter hyperintensity burden; CRC cis rs61776719 0.520 rs12569027 chr1:38449163 C/T cg12658694 chr1:38397304 INPP5B 0.43 6.02 0.31 4.75e-9 Coronary artery disease; CRC cis rs7177699 0.557 rs6495333 chr15:79113215 G/A cg15571903 chr15:79123663 NA 0.31 6.13 0.32 2.47e-9 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; CRC cis rs35883536 1.000 rs2050472 chr1:101125560 T/C cg14515779 chr1:101123966 NA -0.43 -8.31 -0.42 2.55e-15 Monocyte count; CRC trans rs17685 0.753 rs11972240 chr7:75694079 A/C cg19862616 chr7:65841803 NCRNA00174 0.98 18.15 0.71 1.65e-51 Coffee consumption;Coffee consumption (cups per day); CRC cis rs2836974 0.931 rs7283569 chr21:40644062 T/G cg11644478 chr21:40555479 PSMG1 0.81 12.32 0.56 6.05e-29 Cognitive function; CRC cis rs9399135 0.967 rs6902954 chr6:135313994 C/A cg24558204 chr6:135376177 HBS1L 0.5 7.95 0.4 3.01e-14 Red blood cell count; CRC cis rs28386778 0.897 rs2727320 chr17:61865325 T/C cg11494091 chr17:61959527 GH2 0.62 10.57 0.5 1.09e-22 Prudent dietary pattern; CRC cis rs713587 0.571 rs563590 chr2:25331172 A/G cg22495460 chr2:25135724 ADCY3 0.4 6.0 0.31 5.35e-9 Body mass index in non-asthmatics; CRC cis rs9916302 0.706 rs4332770 chr17:37704712 T/C cg15445000 chr17:37608096 MED1 0.35 6.18 0.32 1.91e-9 Glomerular filtration rate (creatinine); CRC cis rs6681460 0.901 rs1373911 chr1:67041065 T/C cg02459107 chr1:67143332 SGIP1 0.45 7.21 0.37 3.85e-12 Presence of antiphospholipid antibodies; CRC cis rs1799949 1.000 rs9646412 chr17:41425893 A/T cg01879757 chr17:41196368 BRCA1 -0.4 -6.0 -0.31 5.24e-9 Menopause (age at onset); CRC cis rs11252926 0.624 rs7085214 chr10:468133 A/G cg03684893 chr10:554711 DIP2C -0.35 -5.95 -0.31 7e-9 Psychosis in Alzheimer's disease; CRC cis rs12612619 0.732 rs10432697 chr2:27272052 T/C cg00617064 chr2:27272375 NA -0.4 -6.69 -0.35 9.89e-11 Venous thromboembolism adjusted for sickle cell variant rs77121243-T; CRC cis rs4073416 0.542 rs10142283 chr14:66044129 G/A cg03016385 chr14:66212404 NA -0.46 -6.32 -0.33 8.4e-10 N-glycan levels; CRC cis rs853679 0.517 rs2273564 chr6:28057594 A/T cg02683197 chr6:28174875 NA 0.82 10.03 0.48 7.9e-21 Depression; CRC cis rs9326248 0.906 rs171052 chr11:117081763 C/G cg26566898 chr11:117069891 TAGLN -0.45 -9.55 -0.47 3.13e-19 Blood protein levels; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg02671540 chr2:61244799 PEX13;PUS10 0.45 6.71 0.35 8.49e-11 Intelligence (multi-trait analysis); CRC cis rs10504229 0.610 rs7840469 chr8:58146992 C/T cg02290350 chr8:58132656 NA -0.53 -7.91 -0.4 3.99e-14 Developmental language disorder (linguistic errors); CRC cis rs4654899 0.833 rs10916858 chr1:21086602 C/G cg02927042 chr1:21476669 EIF4G3 -0.42 -6.55 -0.34 2.22e-10 Superior frontal gyrus grey matter volume; CRC cis rs4665809 0.887 rs4665825 chr2:26333100 A/G cg22920501 chr2:26401640 FAM59B -0.52 -7.16 -0.37 5.39e-12 Gut microbiome composition (summer); CRC trans rs9784649 1.000 rs1493479 chr5:24987768 A/G cg11038491 chr20:34638489 LOC647979 -0.6 -7.21 -0.37 3.93e-12 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs853679 0.517 rs9393890 chr6:28063855 C/T cg02631126 chr6:28058918 ZSCAN12L1 0.3 6.11 0.32 2.83e-9 Depression; CRC cis rs8020095 0.571 rs8009087 chr14:67564210 C/T cg00791868 chr14:66963628 C14orf53 -0.51 -6.87 -0.35 3.14e-11 Depression (quantitative trait); CRC cis rs6951245 0.706 rs28483034 chr7:1170171 C/A cg03188948 chr7:1209495 NA 0.63 7.07 0.36 9.35e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs8060686 0.668 rs255056 chr16:68016185 G/C cg08314208 chr16:67682810 RLTPR -0.66 -7.0 -0.36 1.44e-11 HDL cholesterol;Metabolic syndrome; CRC trans rs11039798 0.858 rs7121333 chr11:48332138 C/T cg15704280 chr7:45808275 SEPT13 0.68 6.52 0.34 2.58e-10 Axial length; CRC cis rs875971 0.862 rs10274883 chr7:66116091 C/T cg00343986 chr7:65444356 GUSB -0.45 -6.2 -0.32 1.7e-9 Aortic root size; CRC cis rs8060686 0.858 rs7206671 chr16:67807146 A/G cg26727032 chr16:67993705 SLC12A4 -0.7 -10.74 -0.51 2.82e-23 HDL cholesterol;Metabolic syndrome; CRC cis rs8060686 0.516 rs7194894 chr16:68145062 C/T cg08314208 chr16:67682810 RLTPR -0.49 -5.88 -0.31 1.01e-8 HDL cholesterol;Metabolic syndrome; CRC cis rs2404602 0.679 rs12900494 chr15:76912504 A/G cg03037974 chr15:76606532 NA 0.69 12.16 0.56 2.4e-28 Blood metabolite levels; CRC cis rs9911578 1.000 rs12952832 chr17:56906254 T/C cg12560992 chr17:57184187 TRIM37 0.91 16.64 0.68 1.56e-45 Intelligence (multi-trait analysis); CRC cis rs7493 0.950 rs17880101 chr7:95031457 A/T cg19678392 chr7:94953810 PON1 -0.59 -7.3 -0.37 2.19e-12 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs6500602 0.727 rs10451135 chr16:4580214 T/C cg14951292 chr16:4525986 HMOX2;NMRAL1 0.56 8.4 0.42 1.31e-15 Schizophrenia; CRC trans rs10242455 0.702 rs78218664 chr7:99154381 C/A cg09045935 chr12:6379348 NA 1.12 8.09 0.41 1.14e-14 Blood metabolite levels; CRC cis rs1190552 0.841 rs56144019 chr14:102949731 G/A cg18135206 chr14:102964638 TECPR2 0.54 6.42 0.33 4.82e-10 Blood protein levels; CRC cis rs10512697 0.803 rs13172911 chr5:3578242 T/C cg19473799 chr5:3511975 NA -0.73 -5.8 -0.3 1.53e-8 Immune response to smallpox vaccine (IL-6); CRC cis rs4911259 0.507 rs8118663 chr20:31398876 A/G cg13636640 chr20:31349939 DNMT3B 0.62 9.42 0.46 8.19e-19 Inflammatory bowel disease; CRC cis rs796364 0.906 rs281789 chr2:200780698 T/G cg12253985 chr2:200820533 C2orf60;C2orf47 0.61 6.71 0.35 8.34e-11 Schizophrenia; CRC trans rs10983614 1.000 rs7867776 chr9:120072627 A/G cg10708793 chr17:40264626 DHX58 0.46 6.35 0.33 7.26e-10 Survival in pancreatic cancer; CRC cis rs7945705 0.935 rs2653593 chr11:8877317 G/A cg00186954 chr11:8933980 ST5;C11orf17 -0.44 -7.11 -0.36 7.23e-12 Hemoglobin concentration; CRC cis rs1670533 0.872 rs13108222 chr4:1054256 C/A cg27284194 chr4:1044797 NA 0.5 6.2 0.32 1.66e-9 Recombination rate (females); CRC cis rs3785574 0.962 rs2584628 chr17:61894578 T/C cg25654072 chr17:61904446 PSMC5;FTSJ3 0.44 6.12 0.32 2.62e-9 Height; CRC cis rs881375 1.000 rs10760118 chr9:123641616 C/T cg14255062 chr9:123606675 PSMD5;LOC253039 0.43 6.3 0.33 9.56e-10 Rheumatoid arthritis; CRC trans rs116095464 0.510 rs60844864 chr5:267000 A/G cg00938859 chr5:1591904 SDHAP3 0.72 7.58 0.39 3.48e-13 Breast cancer; CRC cis rs17345786 0.906 rs55710435 chr3:101180330 G/A cg11279151 chr3:101281821 RG9MTD1 -0.67 -8.41 -0.42 1.27e-15 Colonoscopy-negative controls vs population controls; CRC cis rs9875589 0.509 rs1386932 chr3:14061369 G/A cg14375111 chr3:14165186 TMEM43;CHCHD4 0.39 5.95 0.31 6.75e-9 Ovarian reserve; CRC cis rs908922 0.676 rs526099 chr1:152497811 T/C cg23254163 chr1:152506842 NA 0.5 10.11 0.49 4.05e-21 Hair morphology; CRC cis rs10461617 0.592 rs6450403 chr5:56062737 A/C cg12311346 chr5:56204834 C5orf35 -0.49 -6.48 -0.34 3.28e-10 Type 2 diabetes; CRC cis rs10256972 0.758 rs9801444 chr7:1080444 A/C cg22907277 chr7:1156413 C7orf50 -0.48 -7.04 -0.36 1.11e-11 Longevity;Endometriosis; CRC cis rs7591163 1.000 rs6744308 chr2:228711816 T/G cg22079747 chr2:228736145 WDR69 -0.44 -5.88 -0.31 1.01e-8 Blood pressure; CRC cis rs2530545 0.660 rs2530546 chr7:34697224 C/T cg14401837 chr7:34697493 NPSR1 0.51 6.85 0.35 3.64e-11 IgG glycosylation; CRC cis rs6460942 0.915 rs62447639 chr7:12486803 T/C cg20607287 chr7:12443886 VWDE -0.66 -6.84 -0.35 3.78e-11 Coronary artery disease; CRC trans rs459571 0.834 rs379417 chr9:136890704 G/A cg09836344 chr4:1243392 C4orf42;CTBP1 -0.84 -11.93 -0.55 1.66e-27 Platelet distribution width; CRC cis rs9992667 0.955 rs28418927 chr4:38626130 A/C cg19726192 chr4:38663646 FLJ13197 -0.65 -8.16 -0.41 7.27e-15 Eosinophil percentage of granulocytes; CRC cis rs9325144 0.671 rs7306605 chr12:38730471 C/T cg26384229 chr12:38710491 ALG10B 0.57 8.45 0.42 9.72e-16 Morning vs. evening chronotype; CRC cis rs3736485 0.808 rs55982453 chr15:51951245 C/T cg08986416 chr15:51914746 DMXL2 -0.42 -5.84 -0.31 1.27e-8 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs4689592 0.503 rs2292461 chr4:7058473 C/T cg19539972 chr4:7069911 GRPEL1 0.74 8.67 0.43 1.95e-16 Monocyte percentage of white cells; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg00718791 chr11:76432872 GUCY2E 0.46 6.49 0.34 3.08e-10 Response to antipsychotic treatment; CRC cis rs1179624 0.767 rs12539806 chr7:75257290 C/A cg05145297 chr7:75264568 HIP1 0.53 7.16 0.37 5.15e-12 Age-related nuclear cataracts; CRC cis rs2836974 0.526 rs418359 chr21:40536734 T/C cg06238570 chr21:40685208 BRWD1 -0.79 -12.62 -0.57 4.68e-30 Cognitive function; CRC cis rs3736594 0.722 rs12993377 chr2:27952767 G/C cg27432699 chr2:27873401 GPN1 -0.62 -8.73 -0.43 1.34e-16 Fasting blood glucose;Fasting blood glucose (BMI interaction); CRC cis rs1008375 1.000 rs12507142 chr4:17656103 A/G cg16339924 chr4:17578868 LAP3 0.55 7.44 0.38 8.69e-13 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs897984 0.806 rs8050588 chr16:30937799 G/A cg02466173 chr16:30829666 NA -0.65 -9.93 -0.48 1.73e-20 Dementia with Lewy bodies; CRC cis rs9549328 0.614 rs35872678 chr13:113617231 A/T cg17524180 chr13:113633600 MCF2L 0.52 9.51 0.46 4.32e-19 Systolic blood pressure; CRC cis rs1949733 0.655 rs2631736 chr4:8478421 C/G cg13073564 chr4:8508604 NA 0.49 7.58 0.39 3.47e-13 Response to antineoplastic agents; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg13622267 chr4:68411338 CENPC1 0.49 6.2 0.32 1.72e-9 Thyroid stimulating hormone; CRC cis rs10504229 1.000 rs67594249 chr8:58180521 T/A cg24829409 chr8:58192753 C8orf71 -0.68 -11.34 -0.53 2.27e-25 Developmental language disorder (linguistic errors); CRC cis rs2204008 0.811 rs11520277 chr12:38359611 G/A cg13010199 chr12:38710504 ALG10B 0.47 6.42 0.33 4.78e-10 Bladder cancer; CRC cis rs752010 0.619 rs1123483 chr1:42114198 C/T cg06885757 chr1:42089581 HIVEP3 -0.44 -7.23 -0.37 3.49e-12 Lupus nephritis in systemic lupus erythematosus; CRC cis rs6867032 1.000 rs4246753 chr5:2014721 G/A cg26168224 chr5:2018326 NA 0.98 17.91 0.7 1.45e-50 Gut microbiome composition (winter); CRC cis rs7618915 0.501 rs7622694 chr3:52663882 G/A cg18404041 chr3:52824283 ITIH1 -0.41 -8.63 -0.43 2.69e-16 Bipolar disorder; CRC cis rs9916302 0.752 rs8071300 chr17:37508524 G/C cg00129232 chr17:37814104 STARD3 0.58 7.09 0.36 8.09e-12 Glomerular filtration rate (creatinine); CRC cis rs2549003 1.000 rs10214312 chr5:131821866 T/G cg21138405 chr5:131827807 IRF1 0.57 11.38 0.53 1.59e-25 Asthma (sex interaction); CRC cis rs62064224 0.614 rs4794921 chr17:30742310 C/T cg25809561 chr17:30822961 MYO1D 0.53 9.52 0.46 3.82e-19 Schizophrenia; CRC cis rs28386778 0.897 rs7501614 chr17:61802612 T/C cg23090583 chr17:61904693 PSMC5;FTSJ3 1.03 19.28 0.73 5.63e-56 Prudent dietary pattern; CRC cis rs731174 0.797 rs501252 chr1:38154170 A/G cg06917450 chr1:38156652 C1orf109 -0.52 -7.21 -0.37 3.82e-12 Prostate cancer (SNP x SNP interaction); CRC cis rs6545883 0.965 rs2305155 chr2:61729258 A/G cg15711740 chr2:61764176 XPO1 -0.51 -6.96 -0.36 1.81e-11 Tuberculosis; CRC cis rs1707322 0.717 rs2991989 chr1:46082965 C/T cg06784218 chr1:46089804 CCDC17 -0.66 -12.05 -0.55 5.86e-28 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs854765 0.927 rs12943914 chr17:17980671 A/G cg09796270 chr17:17721594 SREBF1 0.53 8.65 0.43 2.24e-16 Total body bone mineral density; CRC cis rs8060686 0.641 rs3785109 chr16:68118311 G/A cg08314208 chr16:67682810 RLTPR -0.56 -6.06 -0.32 3.72e-9 HDL cholesterol;Metabolic syndrome; CRC cis rs7927771 1.000 rs10838757 chr11:47763016 T/C cg05585544 chr11:47624801 NA -0.61 -10.86 -0.51 1.1e-23 Subjective well-being; CRC cis rs611744 0.647 rs615126 chr8:109247619 C/T cg21045802 chr8:109455806 TTC35 0.42 6.65 0.34 1.24e-10 Dupuytren's disease; CRC cis rs72781680 1.000 rs7581107 chr2:24173565 C/T cg08917208 chr2:24149416 ATAD2B 0.91 9.24 0.45 3.06e-18 Lymphocyte counts; CRC cis rs1865760 0.963 rs1540273 chr6:25924158 T/C cg17691542 chr6:26056736 HIST1H1C 0.56 8.47 0.42 8.18e-16 Height; CRC cis rs1129187 0.755 rs3818554 chr6:42934620 C/T cg03790207 chr6:42947109 PEX6 -0.5 -7.23 -0.37 3.47e-12 Alzheimer's disease in APOE e4+ carriers; CRC cis rs12594515 1.000 rs11070467 chr15:45985001 C/T cg19682013 chr15:45996608 NA -0.35 -7.24 -0.37 3.16e-12 Waist circumference;Weight; CRC cis rs1728785 1.000 rs1170426 chr16:68603798 C/T cg02972257 chr16:68554789 NA -0.6 -7.52 -0.38 5.1e-13 Ulcerative colitis; CRC trans rs11264213 0.643 rs10908407 chr1:36162328 C/T cg07175433 chr4:21947400 KCNIP4 0.37 6.36 0.33 6.71e-10 Schizophrenia; CRC trans rs9858542 0.953 rs9811982 chr3:49624377 A/C cg21659725 chr3:3221576 CRBN -0.75 -10.2 -0.49 2.05e-21 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs1348850 0.958 rs4893941 chr2:178269531 A/T cg02961200 chr2:178257176 LOC100130691;AGPS 0.6 8.99 0.44 2.04e-17 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs7493 0.755 rs17166861 chr7:95020602 G/C cg07404485 chr7:94953653 PON1 -0.43 -5.64 -0.3 3.62e-8 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs60843830 1.000 rs62114544 chr2:269679 C/T cg25945732 chr2:264204 ACP1;SH3YL1 0.71 11.67 0.54 1.46e-26 Spherical equivalent (joint analysis main effects and education interaction); CRC cis rs12188164 0.515 rs2672744 chr5:411047 A/G cg26850624 chr5:429559 AHRR 0.56 9.37 0.46 1.16e-18 Cystic fibrosis severity; CRC cis rs1347297 0.789 rs11688081 chr2:179280799 A/G cg03991736 chr2:179345203 MIR548N;PLEKHA3 -0.41 -5.65 -0.3 3.43e-8 Alzheimer disease and age of onset; CRC cis rs9733 0.596 rs72702556 chr1:150680115 C/T cg15448220 chr1:150897856 SETDB1 0.45 6.41 0.33 5.09e-10 Tonsillectomy; CRC cis rs7618501 1.000 rs6775384 chr3:49853073 G/A cg24308560 chr3:49941425 MST1R -0.46 -7.28 -0.37 2.53e-12 Intelligence (multi-trait analysis); CRC cis rs9902453 0.791 rs55655651 chr17:28244286 T/A cg26525008 chr17:28256777 EFCAB5;SSH2 0.57 8.56 0.43 4.53e-16 Coffee consumption (cups per day); CRC cis rs13161895 1.000 rs3719 chr5:179435118 T/C cg02702477 chr5:179499311 RNF130 -0.56 -6.48 -0.34 3.35e-10 LDL cholesterol; CRC cis rs9322193 0.884 rs1108889 chr6:150166569 A/G cg00933542 chr6:150070202 PCMT1 0.31 6.15 0.32 2.27e-9 Lung cancer; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg16411895 chr7:123174614 IQUB 0.41 6.88 0.35 3.07e-11 Liver disease severity in Alagille syndrome; CRC cis rs270601 0.683 rs81598 chr5:131587960 C/G cg02033258 chr5:131593261 PDLIM4 0.48 8.4 0.42 1.31e-15 Acylcarnitine levels; CRC cis rs7584330 0.737 rs1390985 chr2:238367420 G/A cg16989719 chr2:238392110 NA -0.44 -8.69 -0.43 1.69e-16 Prostate cancer; CRC cis rs4862750 0.872 rs7671914 chr4:187878165 A/G cg11301795 chr4:187892539 NA -0.83 -18.38 -0.71 2.12e-52 Lobe attachment (rater-scored or self-reported); CRC cis rs1005277 0.541 rs2263163 chr10:38389887 G/A cg17219203 chr10:38645113 HSD17B7P2 -0.4 -5.64 -0.3 3.68e-8 Extrinsic epigenetic age acceleration; CRC cis rs1552244 0.882 rs9757159 chr3:10039166 C/T cg16606324 chr3:10149918 C3orf24 0.62 8.08 0.41 1.25e-14 Alzheimer's disease; CRC cis rs4862750 0.832 rs6836426 chr4:187897837 T/G cg06074448 chr4:187884817 NA -0.6 -11.29 -0.53 3.23e-25 Lobe attachment (rater-scored or self-reported); CRC cis rs3820068 0.603 rs6429768 chr1:15963531 G/A cg27534772 chr1:16042836 PLEKHM2 0.55 10.93 0.52 6.22e-24 Systolic blood pressure; CRC trans rs2832077 0.527 rs11088095 chr21:30223188 A/T cg14791747 chr16:20752902 THUMPD1 0.67 10.83 0.51 1.37e-23 Cognitive test performance; CRC cis rs9372498 0.536 rs9489460 chr6:118925754 C/T cg07617317 chr6:118971624 C6orf204 0.49 6.0 0.31 5.29e-9 Diastolic blood pressure; CRC cis rs394563 0.591 rs6570964 chr6:149691859 G/A cg07828024 chr6:149772892 ZC3H12D 0.47 8.73 0.43 1.3e-16 Dupuytren's disease; CRC cis rs6835098 0.961 rs11737748 chr4:174130503 T/C cg08422745 chr4:174089978 GALNT7 0.94 14.18 0.62 5.77e-36 Dementia and core Alzheimer's disease neuropathologic changes; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg24361620 chr11:45868787 CRY2 0.45 6.4 0.33 5.34e-10 Response to antipsychotic treatment; CRC cis rs6570726 0.764 rs448258 chr6:145869145 C/A cg05347473 chr6:146136440 FBXO30 0.39 5.99 0.31 5.54e-9 Lobe attachment (rater-scored or self-reported); CRC trans rs61931739 0.500 rs11053207 chr12:34459827 A/G cg26384229 chr12:38710491 ALG10B 0.62 9.03 0.45 1.52e-17 Morning vs. evening chronotype; CRC cis rs748404 0.660 rs2467738 chr15:43739936 T/A cg02155558 chr15:43621948 ADAL;LCMT2 0.52 7.52 0.38 5.27e-13 Lung cancer; CRC cis rs67311347 1.000 rs2371186 chr3:40488713 G/C cg09455208 chr3:40491958 NA 0.49 9.63 0.47 1.66e-19 Renal cell carcinoma; CRC cis rs62064224 0.589 rs9889607 chr17:30785585 A/C cg18200150 chr17:30822561 MYO1D -0.49 -9.88 -0.48 2.58e-20 Schizophrenia; CRC cis rs7223966 1.000 rs16947042 chr17:61766457 T/G cg23903597 chr17:61704154 MAP3K3 -0.43 -5.85 -0.31 1.19e-8 Hip circumference adjusted for BMI;Body mass index; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg18776286 chr10:52383679 SGMS1 0.46 6.46 0.34 3.78e-10 Anxiety disorder; CRC cis rs236352 0.576 rs2303993 chr6:36842427 C/G cg10099585 chr6:36853529 C6orf89 -0.46 -6.47 -0.34 3.59e-10 Heart rate; CRC cis rs10046574 0.519 rs34274894 chr7:135214725 G/C cg27474649 chr7:135195673 CNOT4 0.6 5.64 0.3 3.6e-8 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs9916302 0.706 rs11655972 chr17:37407072 C/T cg00129232 chr17:37814104 STARD3 -0.57 -7.01 -0.36 1.39e-11 Glomerular filtration rate (creatinine); CRC cis rs2233152 0.572 rs10411008 chr19:41297241 T/C cg21869046 chr19:41225005 ITPKC 0.37 5.86 0.31 1.14e-8 Kawasaki disease; CRC cis rs12476592 0.602 rs6546009 chr2:63745742 G/C cg10828910 chr2:63850056 LOC388955 0.49 6.07 0.32 3.6e-9 Childhood ear infection; CRC cis rs908922 0.676 rs10888492 chr1:152499908 G/C cg09873164 chr1:152488093 CRCT1 0.38 6.34 0.33 7.53e-10 Hair morphology; CRC cis rs9487051 0.698 rs35849756 chr6:109644610 G/A cg01475377 chr6:109611718 NA -0.39 -5.96 -0.31 6.59e-9 Reticulocyte fraction of red cells; CRC cis rs2404602 0.735 rs11629888 chr15:76719880 A/T cg03037974 chr15:76606532 NA -0.51 -7.24 -0.37 3.14e-12 Blood metabolite levels; CRC cis rs7607369 0.637 rs3888879 chr2:219290676 C/T cg02176678 chr2:219576539 TTLL4 -0.53 -7.8 -0.4 8.13e-14 Red blood cell count;Amyotrophic lateral sclerosis; CRC cis rs4700695 0.841 rs251610 chr5:65278481 G/T cg21114390 chr5:65439923 SFRS12 -0.52 -6.34 -0.33 7.61e-10 Facial morphology (factor 19); CRC cis rs4332037 0.538 rs6951956 chr7:1934131 C/T cg25834613 chr7:1915315 MAD1L1 -0.39 -6.13 -0.32 2.5e-9 Bipolar disorder; CRC cis rs3026101 0.671 rs11868032 chr17:5283617 A/T cg25236894 chr17:5323110 RPAIN;NUP88 0.47 7.84 0.4 6.48e-14 Body mass index; CRC cis rs7412746 0.658 rs12068264 chr1:150727329 C/T cg17724175 chr1:150552817 MCL1 0.5 7.33 0.37 1.83e-12 Melanoma; CRC cis rs6951245 0.872 rs77434655 chr7:1098405 G/A cg03188948 chr7:1209495 NA 0.65 6.84 0.35 3.8e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs6504622 0.905 rs3851785 chr17:45040147 T/G cg16759221 chr17:45003025 GOSR2 -0.55 -8.68 -0.43 1.85e-16 Orofacial clefts; CRC cis rs853679 0.517 rs12332979 chr6:28141548 T/G cg06470822 chr6:28175283 NA 1.01 13.28 0.59 1.55e-32 Depression; CRC cis rs77633900 0.614 rs280033 chr15:77023099 G/A cg21673338 chr15:77095150 SCAPER -0.76 -8.0 -0.4 2.14e-14 Non-glioblastoma glioma;Glioma; CRC cis rs2239547 0.657 rs2072391 chr3:52862200 C/T cg10802521 chr3:52805072 NEK4 -0.45 -6.0 -0.31 5.32e-9 Schizophrenia; CRC cis rs55788414 1.000 rs9921827 chr16:81181869 T/C cg06400318 chr16:81190750 PKD1L2 -0.59 -6.78 -0.35 5.73e-11 Left ventricular obstructive tract defect (maternal effect); CRC cis rs10463316 0.823 rs7700340 chr5:150776320 C/T cg03212797 chr5:150827313 SLC36A1 -0.49 -7.82 -0.4 7.31e-14 Metabolite levels (Pyroglutamine); CRC trans rs1642645 0.831 rs1327711 chr1:42495949 A/G cg16926213 chr1:1841314 NA -0.45 -6.44 -0.33 4.25e-10 Left ventricular obstructive tract defect (maternal effect); CRC cis rs6743376 0.556 rs2515398 chr2:113819334 A/C cg09040174 chr2:113837401 NA 0.44 6.44 0.33 4.3e-10 Inflammatory biomarkers; CRC cis rs4523957 0.928 rs422632 chr17:2162049 G/A cg16513277 chr17:2031491 SMG6 0.53 8.76 0.43 1.07e-16 Autism spectrum disorder or schizophrenia;Schizophrenia; CRC cis rs1009181 0.585 rs2183947 chr6:26159356 G/A cg13736514 chr6:26305472 NA -0.42 -6.26 -0.33 1.21e-9 Childhood ear infection; CRC cis rs7385804 0.796 rs221799 chr7:100288545 G/A cg16850897 chr7:100343110 ZAN 0.46 6.99 0.36 1.54e-11 Iron status biomarkers;Mean corpuscular hemoglobin;Hematocrit;Iron status biomarkers (transferrin saturation);Red blood cell count;Iron status biomarkers (iron levels);Mean corpuscular volume;Hematological parameters; CRC cis rs853679 0.517 rs3823180 chr6:28061744 G/A cg15845792 chr6:28175446 NA 0.98 13.03 0.58 1.45e-31 Depression; CRC cis rs3820068 0.603 rs7536654 chr1:15989141 C/G cg24675056 chr1:15929824 NA 0.51 7.31 0.37 2.11e-12 Systolic blood pressure; CRC cis rs7584330 0.704 rs11884395 chr2:238359366 C/T cg16989719 chr2:238392110 NA -0.42 -7.61 -0.39 2.87e-13 Prostate cancer; CRC trans rs10982213 0.830 rs2274163 chr9:117188714 C/T cg07464025 chr10:13482639 BEND7 0.38 6.19 0.32 1.75e-9 Interleukin-6 levels; CRC cis rs55702914 0.712 rs10931778 chr2:198148922 C/T cg20885578 chr2:198174922 NA -0.35 -6.14 -0.32 2.32e-9 Major depression and alcohol dependence; CRC cis rs7618915 0.547 rs13085331 chr3:52627486 G/C cg05573699 chr3:52720067 GNL3;PBRM1 -0.46 -6.62 -0.34 1.44e-10 Bipolar disorder; CRC cis rs10751667 0.961 rs6597971 chr11:928598 T/A ch.11.42038R chr11:967971 AP2A2 0.72 12.01 0.55 8.26e-28 Alzheimer's disease (late onset); CRC cis rs3804749 0.966 rs3792369 chr3:122840731 C/T cg26084141 chr3:122786895 PDIA5 -0.22 -5.95 -0.31 6.95e-9 Plateletcrit;Mean platelet volume;Platelet count;Platelet distribution width; CRC cis rs11098499 0.863 rs2127823 chr4:120485670 G/T cg09307838 chr4:120376055 NA 0.67 10.04 0.48 7.41e-21 Corneal astigmatism; CRC cis rs2576037 0.526 rs9962523 chr18:44486414 A/T cg24750912 chr18:44543259 TCEB3CL;KATNAL2 0.29 5.65 0.3 3.47e-8 Personality dimensions; CRC cis rs6500602 0.647 rs3747600 chr16:4586222 A/G cg14951292 chr16:4525986 HMOX2;NMRAL1 0.57 8.61 0.43 3.07e-16 Schizophrenia; CRC cis rs826838 1.000 rs34254519 chr12:39041235 G/A cg26384229 chr12:38710491 ALG10B 0.72 10.15 0.49 3.07e-21 Heart rate; CRC cis rs8180040 1.000 rs807810 chr3:47403892 G/A cg10298567 chr3:47292165 KIF9 0.39 6.6 0.34 1.62e-10 Colorectal cancer; CRC cis rs7666738 0.830 rs2098934 chr4:98992403 A/G cg05340658 chr4:99064831 C4orf37 0.61 9.54 0.47 3.44e-19 Colonoscopy-negative controls vs population controls; CRC cis rs10256972 0.591 rs11766651 chr7:1161646 A/G cg16145915 chr7:1198662 ZFAND2A -0.45 -8.94 -0.44 2.93e-17 Longevity;Endometriosis; CRC cis rs1799949 1.000 rs12951869 chr17:41187567 T/G cg23758822 chr17:41437982 NA 0.8 13.18 0.59 3.91e-32 Menopause (age at onset); CRC cis rs7224737 1.000 rs11869069 chr17:40287101 C/G cg00647820 chr17:40259828 DHX58 -0.47 -6.67 -0.35 1.06e-10 Fibrinogen levels; CRC cis rs2976388 0.590 rs4736322 chr8:143822208 T/C cg10596483 chr8:143751796 JRK -0.45 -6.39 -0.33 5.8e-10 Urinary tract infection frequency; CRC cis rs9894429 0.646 rs12603868 chr17:79618834 G/C cg21028142 chr17:79581711 NPLOC4 0.36 7.31 0.37 2.1e-12 Eye color traits; CRC cis rs1707322 0.963 rs9787412 chr1:46371596 C/T cg03146154 chr1:46216737 IPP 0.51 7.16 0.37 5.32e-12 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs17152411 0.895 rs61872120 chr10:126583588 T/G cg07906193 chr10:126599966 NA 0.52 5.81 0.3 1.5e-8 Height; CRC cis rs11574514 1.000 rs59343240 chr16:67850529 C/G cg26727032 chr16:67993705 SLC12A4 -0.62 -6.02 -0.31 4.73e-9 Crohn's disease; CRC cis rs3806843 1.000 rs1548700 chr5:140164889 A/T cg19875535 chr5:140030758 IK 0.6 9.79 0.48 4.86e-20 Depressive symptoms (multi-trait analysis); CRC cis rs78456975 0.527 rs10206020 chr2:1557927 A/G cg26248373 chr2:1572462 NA -0.81 -11.22 -0.53 5.8e-25 Placebo response in major depressive disorder (% change in symptom score); CRC cis rs11585357 0.947 rs11585118 chr1:17605774 C/A cg08277548 chr1:17600880 PADI3 -0.9 -11.23 -0.53 5.56e-25 Hair shape; CRC cis rs919433 0.963 rs4850787 chr2:198181750 G/A cg20885578 chr2:198174922 NA -0.39 -6.47 -0.34 3.61e-10 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC cis rs372883 0.648 rs382732 chr21:30719010 A/G cg08807101 chr21:30365312 RNF160 0.5 6.98 0.36 1.67e-11 Pancreatic cancer; CRC cis rs2880765 0.835 rs900573 chr15:86037993 G/T cg17133734 chr15:86042851 AKAP13 -0.43 -6.83 -0.35 4.1e-11 Coronary artery disease; CRC cis rs2013441 1.000 rs2703804 chr17:20107195 T/C cg13482628 chr17:19912719 NA -0.42 -6.57 -0.34 1.95e-10 Obesity-related traits; CRC cis rs7618915 0.571 rs1961959 chr3:52585760 G/C cg11645453 chr3:52864694 ITIH4 0.35 6.19 0.32 1.8e-9 Bipolar disorder; CRC cis rs453301 0.571 rs2929452 chr8:9084465 G/A cg08975724 chr8:8085496 FLJ10661 -0.39 -6.12 -0.32 2.68e-9 Joint mobility (Beighton score); CRC trans rs116095464 0.558 rs56043030 chr5:220917 A/G cg00938859 chr5:1591904 SDHAP3 0.68 7.39 0.38 1.24e-12 Breast cancer; CRC cis rs2075371 1.000 rs1421485 chr7:133985181 C/T cg02659138 chr7:134003124 SLC35B4 0.4 6.96 0.36 1.84e-11 Mean platelet volume; CRC cis rs9443189 0.762 rs2647417 chr6:76435943 A/G cg01950844 chr6:76311363 SENP6 -0.69 -9.28 -0.46 2.42e-18 Prostate cancer; CRC cis rs2797160 1.000 rs61299898 chr6:126007651 G/C cg05901451 chr6:126070800 HEY2 0.4 6.17 0.32 1.99e-9 Endometrial cancer; CRC cis rs7177699 0.526 rs7182529 chr15:79123631 T/C cg15571903 chr15:79123663 NA 0.34 6.92 0.36 2.4e-11 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; CRC cis rs8177253 1.000 rs8177262 chr3:133480652 A/G cg08048268 chr3:133502702 NA 0.37 6.85 0.35 3.69e-11 Iron status biomarkers; CRC trans rs9747201 1.000 rs9747201 chr17:80177852 A/C cg07393940 chr7:158741817 NA 0.52 7.49 0.38 6.46e-13 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs12586317 0.547 rs116499019 chr14:35441931 T/C cg16230307 chr14:35515116 FAM177A1 0.88 10.19 0.49 2.18e-21 Psoriasis; CRC cis rs490234 0.775 rs12341245 chr9:128340941 C/T cg14078157 chr9:128172775 NA -0.39 -6.51 -0.34 2.75e-10 Mean arterial pressure; CRC cis rs2153535 0.541 rs5026687 chr6:8473957 A/T cg21535247 chr6:8435926 SLC35B3 0.51 7.71 0.39 1.54e-13 Motion sickness; CRC cis rs897984 0.806 rs1046276 chr16:30914626 A/G cg02466173 chr16:30829666 NA 0.62 9.1 0.45 8.64e-18 Dementia with Lewy bodies; CRC cis rs12476592 0.602 rs2121351 chr2:63828361 G/A cg10828910 chr2:63850056 LOC388955 0.5 6.13 0.32 2.54e-9 Childhood ear infection; CRC trans rs1997103 1.000 rs6957984 chr7:55397331 G/A cg20935933 chr6:143382018 AIG1 0.52 6.72 0.35 7.9e-11 QRS interval (sulfonylurea treatment interaction); CRC cis rs2949837 0.581 rs2949838 chr7:45993924 T/C cg06713098 chr7:45960367 IGFBP3 0.43 6.92 0.36 2.34e-11 Sitting height ratio; CRC cis rs853679 0.517 rs6941992 chr6:28106141 T/C cg23161317 chr6:28129485 ZNF389 0.53 6.54 0.34 2.37e-10 Depression; CRC cis rs896854 0.654 rs4735340 chr8:95976251 A/T cg16049864 chr8:95962084 TP53INP1 -0.65 -11.81 -0.55 4.64e-27 Type 2 diabetes; CRC cis rs769267 0.965 rs2916068 chr19:19516433 A/G cg02546618 chr19:19431379 KIAA0892;SF4 0.46 6.44 0.33 4.28e-10 Tonsillectomy; CRC cis rs2811415 0.597 rs10934837 chr3:127726173 A/G cg13719885 chr3:127795394 NA -0.38 -5.83 -0.31 1.32e-8 Lung function (FEV1/FVC); CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg14976978 chr11:67159397 RAD9A -0.4 -6.22 -0.32 1.54e-9 Myopia (pathological); CRC cis rs9612 1.000 rs1059 chr19:44268348 C/T cg08581076 chr19:44259116 C19orf61 0.48 6.18 0.32 1.86e-9 Exhaled nitric oxide output; CRC cis rs12142240 0.698 rs1984490 chr1:46858734 C/T cg00530320 chr1:46809349 NSUN4 -0.59 -8.21 -0.41 5.06e-15 Menopause (age at onset); CRC cis rs1862618 0.756 rs832548 chr5:56183637 G/C cg03609598 chr5:56110824 MAP3K1 -0.85 -10.06 -0.49 6.18e-21 Initial pursuit acceleration; CRC cis rs7584330 0.826 rs7604315 chr2:238381729 C/G cg14458575 chr2:238380390 NA 0.7 12.62 0.57 4.66e-30 Prostate cancer; CRC cis rs2011503 1.000 rs8111093 chr19:19505548 C/T cg11584989 chr19:19387371 SF4 0.55 6.36 0.33 6.6e-10 Bipolar disorder; CRC cis rs736408 0.609 rs13095332 chr3:52787242 C/T cg18404041 chr3:52824283 ITIH1 -0.43 -8.9 -0.44 3.76e-17 Bipolar disorder; CRC cis rs1005277 0.541 rs1740741 chr10:38515334 C/T cg03665457 chr10:38645376 HSD17B7P2 -0.42 -5.96 -0.31 6.58e-9 Extrinsic epigenetic age acceleration; CRC cis rs9467773 0.506 rs9393709 chr6:26365147 C/T cg09904177 chr6:26538194 HMGN4 -0.44 -6.04 -0.32 4.12e-9 Intelligence (multi-trait analysis); CRC trans rs7618501 0.699 rs2681780 chr3:49897830 C/T cg21665057 chr3:196295764 WDR53;FBXO45 0.68 10.64 0.51 6.41e-23 Intelligence (multi-trait analysis); CRC cis rs4853012 0.838 rs12619982 chr2:74356022 G/A cg19729930 chr2:74357872 NA 0.74 11.21 0.53 6.57e-25 Gestational age at birth (maternal effect); CRC cis rs752010 1.000 rs6664724 chr1:42093821 G/A cg06885757 chr1:42089581 HIVEP3 0.49 8.51 0.42 6.42e-16 Lupus nephritis in systemic lupus erythematosus; CRC cis rs9389248 0.737 rs12664956 chr6:135384188 T/C cg24558204 chr6:135376177 HBS1L 0.61 9.06 0.45 1.23e-17 High light scatter reticulocyte percentage of red cells; CRC cis rs6429082 0.738 rs2131921 chr1:235705157 C/T cg26050004 chr1:235667680 B3GALNT2 0.49 6.49 0.34 3.18e-10 Adiposity; CRC cis rs1577917 0.958 rs6454488 chr6:86450842 T/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.52 -7.11 -0.36 7.42e-12 Response to antipsychotic treatment; CRC cis rs9487051 1.000 rs9487048 chr6:109615603 G/T cg21918786 chr6:109611834 NA -0.38 -6.56 -0.34 2.09e-10 Reticulocyte fraction of red cells; CRC trans rs2014572 0.967 rs10421632 chr19:57764770 G/A cg02674126 chr19:40336878 FBL 0.42 6.74 0.35 6.98e-11 Hyperactive-impulsive symptoms; CRC trans rs9329221 0.698 rs12547997 chr8:10260837 A/G cg06636001 chr8:8085503 FLJ10661 0.49 7.61 0.39 2.85e-13 Neuroticism; CRC cis rs6502050 0.835 rs12051747 chr17:80114814 T/C cg22110888 chr17:80059540 CCDC57 0.4 6.33 0.33 8.16e-10 Life satisfaction; CRC cis rs1215050 0.791 rs783969 chr4:98906504 C/T cg05340658 chr4:99064831 C4orf37 0.5 7.26 0.37 2.73e-12 Waist-to-hip ratio adjusted for body mass index; CRC cis rs4253772 0.550 rs738444 chr22:46721088 C/T cg24881330 chr22:46731750 TRMU 0.71 8.88 0.44 4.41e-17 LDL cholesterol;Cholesterol, total; CRC cis rs7552404 1.000 rs2133134 chr1:76179587 G/A cg22875332 chr1:76189707 ACADM 0.7 9.4 0.46 9.55e-19 Blood metabolite levels;Acylcarnitine levels; CRC cis rs12477438 0.715 rs6724476 chr2:99627316 C/T cg26064155 chr2:99771622 LIPT1;TSGA10 -0.62 -8.53 -0.43 5.31e-16 Chronic sinus infection; CRC cis rs4711336 1.000 rs3818523 chr6:33660371 G/A cg14003231 chr6:33640908 ITPR3 0.46 7.36 0.38 1.52e-12 Height; CRC cis rs2404602 0.669 rs17367297 chr15:77158026 A/C cg23625390 chr15:77176239 SCAPER 0.46 6.54 0.34 2.39e-10 Blood metabolite levels; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg02573121 chr1:46806359 NSUN4 0.4 6.07 0.32 3.47e-9 Intelligence (multi-trait analysis); CRC cis rs10540 1.000 rs10540 chr11:494662 G/A cg03934478 chr11:495069 RNH1 0.69 7.73 0.39 1.28e-13 Body mass index; CRC cis rs868943 0.743 rs10457303 chr6:116413841 C/T cg26893134 chr6:116381904 FRK 0.26 6.34 0.33 7.49e-10 Total cholesterol levels; CRC trans rs9929218 0.954 rs10163398 chr16:68823124 C/G cg04657470 chr2:198365150 HSPE1;HSPD1 -0.77 -11.19 -0.53 7.43e-25 Colorectal cancer; CRC cis rs7959452 0.590 rs10878974 chr12:69781528 C/G cg22834771 chr12:69754056 YEATS4 -0.54 -8.1 -0.41 1.07e-14 Blood protein levels; CRC cis rs1729951 0.575 rs835642 chr3:136703365 A/T cg21827317 chr3:136751795 NA 0.35 5.81 0.31 1.44e-8 Neuroticism; CRC cis rs79839061 0.610 rs11248051 chr4:858332 C/T cg14530993 chr4:882597 GAK 0.82 7.82 0.4 7.15e-14 Intelligence (multi-trait analysis); CRC cis rs9611565 0.512 rs6002474 chr22:42168181 A/G cg06481639 chr22:41940642 POLR3H 0.56 6.24 0.33 1.38e-9 Vitiligo; CRC cis rs8177179 0.967 rs6439436 chr3:133453779 C/T cg17775713 chr3:133465469 TF -0.38 -6.96 -0.36 1.85e-11 Iron status biomarkers (transferrin levels); CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg12373195 chr12:64798416 XPOT 0.39 5.97 0.31 6.06e-9 Anxiety disorder; CRC cis rs801193 1.000 rs7789184 chr7:66210195 A/T cg18876405 chr7:65276391 NA 0.6 10.61 0.51 7.98e-23 Aortic root size; CRC cis rs3814231 0.531 rs11196446 chr10:115471016 A/C cg24846397 chr10:115438155 CASP7 -0.35 -5.7 -0.3 2.6e-8 Vitiligo; CRC cis rs4819052 0.851 rs34101026 chr21:46662200 C/T cg11663144 chr21:46675770 NA -0.83 -14.01 -0.61 2.7900000000000003e-35 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs3862260 0.509 rs3862262 chr1:120161841 G/T cg16322792 chr1:120165303 ZNF697 0.47 8.31 0.42 2.63e-15 Systemic lupus erythematosus; CRC cis rs483180 0.511 rs496198 chr1:120207177 A/G cg19096424 chr1:120255104 PHGDH -0.44 -6.36 -0.33 6.91e-10 Macular telangiectasia type 2; CRC cis rs1018836 0.812 rs10808619 chr8:91622916 A/T cg16814680 chr8:91681699 NA -0.76 -12.39 -0.56 3.32e-29 Ejection fraction in Tripanosoma cruzi seropositivity; CRC cis rs711830 0.931 rs717852 chr2:177031623 C/T cg13092806 chr2:177043255 NA 0.73 8.75 0.43 1.15e-16 Serous invasive ovarian cancer;Epithelial ovarian cancer;Invasive epithelial ovarian cancer;Mucinous ovarian carcinoma;Low-grade serous and serous borderline ovarian cancer;Serous borderline ovarian cancer;High-grade serous ovarian cancer; CRC cis rs7552404 0.727 rs1146653 chr1:76280438 A/G cg10523679 chr1:76189770 ACADM 0.65 8.79 0.44 8.24e-17 Blood metabolite levels;Acylcarnitine levels; CRC cis rs2839186 0.770 rs2839171 chr21:47673247 C/T cg05896524 chr21:47604654 C21orf56 -0.46 -7.02 -0.36 1.27e-11 Testicular germ cell tumor; CRC trans rs3942852 0.545 rs10838798 chr11:48091303 T/G cg15704280 chr7:45808275 SEPT13 -0.68 -9.65 -0.47 1.43e-19 Acute lymphoblastic leukemia (childhood); CRC cis rs10174077 0.874 rs11892439 chr2:152469858 T/A cg19508488 chr2:152266495 RIF1 0.49 6.91 0.36 2.5e-11 Squamous cell lung carcinoma; CRC cis rs2530545 0.762 rs10245221 chr7:34667197 A/C cg14401837 chr7:34697493 NPSR1 -0.43 -6.35 -0.33 7.1e-10 IgG glycosylation; CRC cis rs6502050 0.731 rs9892653 chr17:80100191 G/T cg11859384 chr17:80120422 CCDC57 -0.37 -5.85 -0.31 1.16e-8 Life satisfaction; CRC cis rs9611565 0.729 rs2413647 chr22:41907148 G/A cg06481639 chr22:41940642 POLR3H -0.57 -6.56 -0.34 2.06e-10 Vitiligo; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg03689054 chr17:81037743 METRNL 0.4 6.05 0.32 3.83e-9 Intelligence (multi-trait analysis); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg01334186 chr1:151372572 PSMB4 0.44 6.31 0.33 9.14e-10 Response to antipsychotic treatment; CRC cis rs939584 0.866 rs13405307 chr2:650973 T/C cg03610516 chr2:642275 NA -0.42 -5.89 -0.31 9.46e-9 Body mass index; CRC cis rs2463822 1.000 rs2463820 chr11:62112290 A/T cg06239285 chr11:62104954 ASRGL1 1.06 11.64 0.54 1.85e-26 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs6840360 0.571 rs1473305 chr4:152511721 T/G cg09659197 chr4:152720779 NA 0.31 5.67 0.3 3.05e-8 Intelligence (multi-trait analysis); CRC cis rs10504229 0.953 rs78089850 chr8:58171557 A/G cg01721255 chr8:58191610 C8orf71 0.53 6.6 0.34 1.69e-10 Developmental language disorder (linguistic errors); CRC cis rs4319547 0.656 rs7135419 chr12:122911861 T/A cg23029597 chr12:123009494 RSRC2 -0.56 -6.91 -0.36 2.5e-11 Body mass index; CRC cis rs2735413 0.881 rs11150036 chr16:78075687 C/G cg04733911 chr16:78082701 NA -0.43 -7.11 -0.36 7.29e-12 Systolic blood pressure (alcohol consumption interaction); CRC trans rs35110281 0.693 rs2838345 chr21:45092715 C/T cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.4 6.55 0.34 2.26e-10 Mean corpuscular volume; CRC trans rs3733585 0.673 rs4495037 chr4:9954050 C/G cg26043149 chr18:55253948 FECH -0.5 -7.71 -0.39 1.51e-13 Cleft plate (environmental tobacco smoke interaction); CRC cis rs1448094 0.549 rs4919770 chr12:86238050 G/T cg19622623 chr12:86230825 RASSF9 -0.38 -6.28 -0.33 1.09e-9 Major depressive disorder; CRC cis rs7737355 0.947 rs32115 chr5:131051328 A/G cg06307176 chr5:131281290 NA 0.4 5.89 0.31 9.46e-9 Life satisfaction; CRC cis rs728616 0.867 rs12413715 chr10:81687360 G/T cg05935833 chr10:81318306 SFTPA2 -0.72 -8.2 -0.41 5.51e-15 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs172166 0.694 rs2791332 chr6:28108788 C/T cg06470822 chr6:28175283 NA 0.81 12.0 0.55 9.1e-28 Cardiac Troponin-T levels; CRC cis rs375066 0.551 rs10500286 chr19:44331613 T/C cg19542119 chr19:44331823 ZNF283 0.41 5.74 0.3 2.1e-8 Breast cancer; CRC cis rs651907 0.557 rs36002990 chr3:101437862 G/A cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.59 7.94 0.4 3.21e-14 Colorectal cancer; CRC cis rs4713118 0.614 rs9380007 chr6:27660508 T/C cg06470822 chr6:28175283 NA 0.59 8.56 0.43 4.49e-16 Parkinson's disease; CRC cis rs477692 0.597 rs574831 chr10:131379190 C/T cg05714579 chr10:131428358 MGMT -0.47 -6.58 -0.34 1.88e-10 Response to temozolomide; CRC cis rs9488822 0.676 rs11153593 chr6:116335131 C/A cg18764771 chr6:116381957 FRK 0.25 7.1 0.36 7.64e-12 Cholesterol, total;LDL cholesterol; CRC cis rs2629540 0.847 rs10901807 chr10:126384610 G/A cg08799069 chr10:126477246 METTL10 0.62 7.94 0.4 3.25e-14 Cocaine dependence; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg16790682 chr12:57984821 PIP4K2C 0.41 6.18 0.32 1.93e-9 Intelligence (multi-trait analysis); CRC cis rs1865760 0.865 rs6929805 chr6:25950834 T/A cg16482183 chr6:26056742 HIST1H1C 0.55 7.99 0.4 2.25e-14 Height; CRC cis rs17253792 0.822 rs77182097 chr14:56136695 G/A cg24579896 chr14:56047964 C14orf33;KTN1 0.7 5.66 0.3 3.3e-8 Putamen volume; CRC cis rs12143943 0.866 rs12030639 chr1:204530924 C/T cg17419461 chr1:204415978 PIK3C2B 0.39 6.21 0.32 1.61e-9 Cognitive performance; CRC cis rs7613875 0.663 rs6762477 chr3:50093209 G/A cg24308560 chr3:49941425 MST1R 0.43 6.6 0.34 1.69e-10 Body mass index; CRC cis rs11971779 0.680 rs4732370 chr7:139077240 A/C cg07862535 chr7:139043722 LUC7L2 -0.55 -6.96 -0.36 1.83e-11 Diisocyanate-induced asthma; CRC cis rs760805 1.000 rs10903115 chr1:25261696 A/G cg22509179 chr1:25234806 RUNX3 -0.57 -8.93 -0.44 3.07e-17 Allergic disease (asthma, hay fever or eczema); CRC cis rs68170813 0.559 rs12536485 chr7:106978005 T/C cg02696742 chr7:106810147 HBP1 -0.58 -6.28 -0.33 1.08e-9 Coronary artery disease; CRC cis rs10207060 0.771 rs4852124 chr2:240680022 C/T cg20333904 chr2:240724165 NA -0.34 -6.66 -0.34 1.15e-10 Obesity-related traits; CRC cis rs10540 1.000 rs12788729 chr11:502371 G/A cg19913688 chr11:428466 ANO9 -0.7 -7.19 -0.37 4.26e-12 Body mass index; CRC cis rs7074356 0.688 rs7898558 chr10:82183505 G/T cg27171509 chr10:82033454 MAT1A -0.36 -6.62 -0.34 1.5e-10 Borderline personality disorder; CRC cis rs10504229 0.953 rs75253516 chr8:58171547 C/A cg02290350 chr8:58132656 NA -0.42 -5.9 -0.31 8.92e-9 Developmental language disorder (linguistic errors); CRC cis rs10504229 1.000 rs73609747 chr8:58189104 G/C cg22535103 chr8:58192502 C8orf71 -0.82 -12.27 -0.56 9.63e-29 Developmental language disorder (linguistic errors); CRC cis rs67311347 1.000 rs73080165 chr3:40533062 G/T cg09455208 chr3:40491958 NA 0.43 8.21 0.41 5.2e-15 Renal cell carcinoma; CRC cis rs826838 1.000 rs2129627 chr12:38653036 C/T cg26384229 chr12:38710491 ALG10B 0.72 10.23 0.49 1.61e-21 Heart rate; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg02401220 chr17:39845253 EIF1 0.49 7.77 0.39 9.92e-14 Liver disease severity in Alagille syndrome; CRC cis rs6912958 0.559 rs376633 chr6:88042785 T/C cg12350822 chr6:88032061 C6orf162;GJB7 0.47 9.66 0.47 1.3e-19 Monocyte percentage of white cells; CRC cis rs7772486 0.902 rs2144476 chr6:146322484 G/A cg23711669 chr6:146136114 FBXO30 0.61 10.18 0.49 2.43e-21 Lobe attachment (rater-scored or self-reported); CRC cis rs7618915 0.501 rs34754793 chr3:52629177 A/T cg11645453 chr3:52864694 ITIH4 0.36 6.48 0.34 3.43e-10 Bipolar disorder; CRC cis rs9486719 1.000 rs12212614 chr6:97036466 T/G cg18709589 chr6:96969512 KIAA0776 -0.52 -5.83 -0.31 1.3e-8 Migraine;Coronary artery disease; CRC cis rs4664308 0.618 rs4665138 chr2:160890427 C/T cg03641300 chr2:160917029 PLA2R1 -0.55 -8.24 -0.41 4.15e-15 Idiopathic membranous nephropathy; CRC cis rs2032447 0.714 rs2051540 chr6:25947197 T/C cg18357526 chr6:26021779 HIST1H4A 0.69 10.0 0.48 9.65e-21 Intelligence (multi-trait analysis); CRC cis rs7659604 0.539 rs3217771 chr4:122739483 G/A cg20573242 chr4:122745356 CCNA2 0.57 8.5 0.42 6.7e-16 Type 2 diabetes; CRC cis rs7725052 0.609 rs12520532 chr5:40455445 T/C cg09067459 chr5:40385259 NA -0.4 -6.58 -0.34 1.86e-10 Pediatric autoimmune diseases; CRC cis rs58688157 0.639 rs60568231 chr11:575553 A/T cg16486109 chr11:613632 IRF7 0.7 11.59 0.54 2.75e-26 Systemic lupus erythematosus; CRC cis rs1799949 1.000 rs915945 chr17:41179864 C/T cg25072359 chr17:41440525 NA 0.45 6.54 0.34 2.33e-10 Menopause (age at onset); CRC cis rs4689388 0.890 rs1801206 chr4:6302707 C/T cg14416269 chr4:6271139 WFS1 0.41 6.74 0.35 7.2e-11 Type 2 diabetes and other traits;Type 2 diabetes; CRC cis rs10788264 0.504 rs4751883 chr10:124018027 A/C cg09507567 chr10:124027408 NA 0.35 7.54 0.38 4.76e-13 Total body bone mineral density; CRC cis rs3796352 0.667 rs3755805 chr3:52866299 G/A cg06204229 chr3:52865917 ITIH4 0.63 7.37 0.38 1.41e-12 Immune reponse to smallpox (secreted IL-2); CRC cis rs4865169 0.595 rs4865165 chr4:57765546 A/G cg24291500 chr4:57773398 REST -0.29 -5.83 -0.31 1.3e-8 Breast cancer; CRC cis rs801193 1.000 rs6958520 chr7:66151453 T/C cg11764359 chr7:65958608 NA 0.54 8.3 0.42 2.67e-15 Aortic root size; CRC cis rs4862750 0.872 rs6825289 chr4:187879109 T/G cg27532560 chr4:187881888 NA -0.55 -10.06 -0.48 6.26e-21 Lobe attachment (rater-scored or self-reported); CRC cis rs9916302 0.851 rs6503502 chr17:37501855 A/G cg00129232 chr17:37814104 STARD3 0.54 7.97 0.4 2.68e-14 Glomerular filtration rate (creatinine); CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg22708233 chr11:47198576 ARFGAP2 0.36 6.24 0.33 1.35e-9 Obesity-related traits; CRC cis rs13191362 0.935 rs34934114 chr6:163082480 G/A cg21926612 chr6:163149169 PACRG;PARK2 0.97 12.62 0.57 4.78e-30 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs34172651 0.917 rs11074651 chr16:24778409 A/G cg04756594 chr16:24857601 SLC5A11 0.23 5.76 0.3 1.88e-8 Intelligence (multi-trait analysis); CRC cis rs13191362 1.000 rs28360546 chr6:163210973 G/A cg23758597 chr6:163146217 PARK2 -0.65 -6.46 -0.34 3.77e-10 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs1005277 0.602 rs1780141 chr10:38504299 T/C cg03665457 chr10:38645376 HSD17B7P2 -0.42 -5.97 -0.31 6.02e-9 Extrinsic epigenetic age acceleration; CRC cis rs4664308 0.618 rs17830904 chr2:160891688 C/T cg03641300 chr2:160917029 PLA2R1 0.55 8.37 0.42 1.64e-15 Idiopathic membranous nephropathy; CRC cis rs9916302 0.904 rs7216086 chr17:37709422 G/A cg20243544 chr17:37824526 PNMT 0.4 5.63 0.3 3.87e-8 Glomerular filtration rate (creatinine); CRC trans rs7826238 0.535 rs2979179 chr8:8320029 C/T cg16141378 chr3:129829833 LOC729375 -0.46 -7.08 -0.36 8.9e-12 Systolic blood pressure; CRC cis rs7613875 0.600 rs7061 chr3:50114515 C/T cg24308560 chr3:49941425 MST1R 0.39 5.94 0.31 7.41e-9 Body mass index; CRC cis rs11190604 0.767 rs10883491 chr10:102196071 G/T cg16342193 chr10:102329863 NA -0.35 -5.82 -0.31 1.39e-8 Palmitoleic acid (16:1n-7) levels; CRC cis rs4654899 0.802 rs10916903 chr1:21247944 T/C cg02927042 chr1:21476669 EIF4G3 -0.49 -7.54 -0.38 4.76e-13 Superior frontal gyrus grey matter volume; CRC cis rs10504229 1.000 rs58382845 chr8:58169851 A/C cg05313129 chr8:58192883 C8orf71 -0.46 -6.81 -0.35 4.6e-11 Developmental language disorder (linguistic errors); CRC cis rs4654899 0.802 rs12127519 chr1:21247365 C/T cg02927042 chr1:21476669 EIF4G3 -0.5 -7.99 -0.4 2.27e-14 Superior frontal gyrus grey matter volume; CRC cis rs3736485 0.844 rs67524810 chr15:51805291 A/C cg08986416 chr15:51914746 DMXL2 -0.48 -6.93 -0.36 2.29e-11 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs7208859 0.623 rs9906957 chr17:29157755 C/T cg01831904 chr17:28903510 LRRC37B2 -0.58 -6.21 -0.32 1.62e-9 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs4711336 1.000 rs2296736 chr6:33656250 T/C cg14003231 chr6:33640908 ITPR3 0.52 8.25 0.41 3.94e-15 Height; CRC cis rs1448094 0.512 rs7957170 chr12:86243282 A/G cg00310523 chr12:86230176 RASSF9 0.33 5.62 0.3 3.97e-8 Major depressive disorder; CRC trans rs17685 0.753 rs869804 chr7:75688954 A/G cg19862616 chr7:65841803 NCRNA00174 0.99 18.55 0.71 4.31e-53 Coffee consumption;Coffee consumption (cups per day); CRC cis rs9355610 0.609 rs3756838 chr6:167371251 G/A cg23791538 chr6:167370224 RNASET2 0.54 7.53 0.38 4.79e-13 Graves' disease; CRC cis rs6502050 0.697 rs8078634 chr17:80126208 C/T cg22110888 chr17:80059540 CCDC57 0.43 6.77 0.35 5.97e-11 Life satisfaction; CRC cis rs853679 0.517 rs9380065 chr6:28144751 A/G cg12172441 chr6:28176163 NA 0.63 7.43 0.38 9.41e-13 Depression; CRC trans rs2303319 0.504 rs62189053 chr2:162624324 G/A cg23247704 chr1:116518985 SLC22A15 -0.72 -6.12 -0.32 2.7e-9 Cognitive function; CRC trans rs2228479 0.850 rs11076619 chr16:89831243 C/A cg24644049 chr4:85504048 CDS1 0.87 7.08 0.36 8.68e-12 Skin colour saturation; CRC cis rs8031584 0.958 rs7168641 chr15:31235452 G/A cg08109568 chr15:31115862 NA -0.52 -8.48 -0.42 7.57e-16 Huntington's disease progression; CRC cis rs7615952 0.599 rs7652883 chr3:125707977 T/G cg05084668 chr3:125655381 ALG1L -0.47 -6.84 -0.35 3.84e-11 Blood pressure (smoking interaction); CRC cis rs17092148 1.000 rs1884431 chr20:33338585 G/A cg08999081 chr20:33150536 PIGU 0.45 5.69 0.3 2.78e-8 Neuroticism; CRC cis rs13315871 1.000 rs75828026 chr3:58346736 C/T cg20936604 chr3:58311152 NA -0.76 -7.23 -0.37 3.46e-12 Cholesterol, total; CRC cis rs459193 1.000 rs465002 chr5:55808475 C/T cg26646659 chr5:55776364 NA 0.42 5.65 0.3 3.48e-8 Coronary artery disease;Type 2 diabetes;Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);Waist-to-hip ratio adjusted for BMI in non-smokers;Waist-to-hip ratio adjusted for BMI (smoking interaction);Waist-to-hip ratio adjusted for body mass index;Waist-hip ratio;Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction); CRC cis rs6700896 0.931 rs7546242 chr1:66093030 C/T cg04111102 chr1:66153794 NA 0.33 5.81 0.31 1.48e-8 C-reactive protein;Mean corpuscular volume;Mean corpuscular hemoglobin; CRC trans rs11098499 0.562 rs2389879 chr4:120557684 G/A cg25214090 chr10:38739885 LOC399744 -0.52 -8.18 -0.41 6.09e-15 Corneal astigmatism; CRC cis rs9322193 0.923 rs9767554 chr6:149937996 T/C cg05861140 chr6:150128134 PCMT1 -0.35 -5.64 -0.3 3.6e-8 Lung cancer; CRC cis rs28386778 0.897 rs2584617 chr17:61925298 C/T cg07362569 chr17:61921086 SMARCD2 0.37 5.73 0.3 2.33e-8 Prudent dietary pattern; CRC cis rs1552244 0.882 rs7633769 chr3:10020622 C/T cg16606324 chr3:10149918 C3orf24 0.6 8.14 0.41 8.28e-15 Alzheimer's disease; CRC cis rs2651899 0.934 rs1627080 chr1:3081309 T/C cg22674798 chr1:3096360 PRDM16 0.38 7.79 0.39 9.06e-14 Migraine; CRC cis rs7927771 1.000 rs11605774 chr11:47832793 G/A cg20307385 chr11:47447363 PSMC3 -0.49 -6.49 -0.34 3.07e-10 Subjective well-being; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg23436918 chr7:16685595 BZW2;ANKMY2 0.44 6.37 0.33 6.5e-10 Response to antipsychotic treatment; CRC trans rs2303319 0.504 rs62187597 chr2:162398263 A/T cg27113153 chr11:123612418 ZNF202 -0.72 -6.15 -0.32 2.25e-9 Cognitive function; CRC cis rs9322193 0.884 rs933055 chr6:150130837 A/G cg00933542 chr6:150070202 PCMT1 0.28 5.64 0.3 3.7e-8 Lung cancer; CRC cis rs938554 0.784 rs13102218 chr4:9976113 G/T cg00071950 chr4:10020882 SLC2A9 0.47 6.65 0.34 1.21e-10 Blood metabolite levels; CRC cis rs7119 0.604 rs2682924 chr15:77863720 C/T cg27398640 chr15:77910606 LINGO1 -0.43 -7.61 -0.39 2.84e-13 Type 2 diabetes; CRC cis rs3096299 0.503 rs9940093 chr16:89558705 G/A cg08392591 chr16:89556376 ANKRD11 0.47 6.4 0.33 5.29e-10 Multiple myeloma (IgH translocation); CRC cis rs5769707 0.967 rs2051626 chr22:50008973 G/A cg20744362 chr22:50050164 C22orf34 0.33 6.61 0.34 1.55e-10 Monocyte count;Monocyte percentage of white cells; CRC cis rs617791 0.669 rs4994056 chr11:65750997 G/A cg17985854 chr11:65770987 BANF1;EIF1AD 0.51 8.69 0.43 1.73e-16 Breast cancer; CRC cis rs6563739 0.628 rs9603588 chr13:40224412 T/C cg00026919 chr13:40226031 NA 0.5 6.41 0.33 4.98e-10 Menarche (age at onset); CRC cis rs3768617 0.510 rs10752899 chr1:183081241 T/G ch.1.3577855R chr1:183094577 LAMC1 0.88 15.62 0.65 1.5e-41 Fuchs's corneal dystrophy; CRC cis rs7772486 0.875 rs9322043 chr6:146352690 A/G cg23711669 chr6:146136114 FBXO30 0.7 12.18 0.56 1.99e-28 Lobe attachment (rater-scored or self-reported); CRC cis rs7412746 0.658 rs72704682 chr1:150897677 A/T cg17724175 chr1:150552817 MCL1 0.44 6.71 0.35 8.35e-11 Melanoma; CRC cis rs6499255 0.951 rs56316408 chr16:69658776 A/G cg15192750 chr16:69999425 NA 0.55 7.27 0.37 2.58e-12 IgE levels; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg21838329 chr15:81173075 KIAA1199 0.35 6.15 0.32 2.23e-9 Liver disease severity in Alagille syndrome; CRC cis rs17152411 1.000 rs11245440 chr10:126634572 C/T cg07906193 chr10:126599966 NA 0.57 5.74 0.3 2.15e-8 Height; CRC cis rs9296095 1.000 rs9296095 chr6:33542523 A/G cg14003231 chr6:33640908 ITPR3 0.49 7.03 0.36 1.23e-11 Platelet count; CRC cis rs798554 0.686 rs7777484 chr7:2814271 A/G cg04166393 chr7:2884313 GNA12 0.39 5.72 0.3 2.43e-8 Height; CRC cis rs853679 0.517 rs9393891 chr6:28079160 C/T cg18032046 chr6:28092343 ZSCAN16 -0.52 -6.02 -0.31 4.76e-9 Depression; CRC cis rs736408 0.608 rs35004449 chr3:52852897 G/T cg18404041 chr3:52824283 ITIH1 -0.41 -7.59 -0.39 3.36e-13 Bipolar disorder; CRC cis rs7091068 0.518 rs1572772 chr10:95432862 A/G cg20715218 chr10:95462985 C10orf4 -0.52 -7.1 -0.36 7.96e-12 Urinary tract infection frequency; CRC cis rs9818758 0.607 rs56004653 chr3:49072228 T/C cg00383909 chr3:49044727 WDR6 1.36 11.14 0.52 1.1e-24 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; CRC cis rs2708977 0.667 rs772156 chr2:97029830 G/A cg23100626 chr2:96804247 ASTL 0.23 6.08 0.32 3.29e-9 Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes; CRC cis rs6502050 0.604 rs9897355 chr17:80078095 G/A cg09264619 chr17:80180166 NA 0.39 6.5 0.34 3.04e-10 Life satisfaction; CRC cis rs9322193 0.923 rs1984111 chr6:150152856 G/A cg05861140 chr6:150128134 PCMT1 -0.42 -6.79 -0.35 5.4e-11 Lung cancer; CRC cis rs354225 0.615 rs12713274 chr2:54848728 C/T cg26097391 chr2:54893211 SPTBN1 -0.4 -6.16 -0.32 2.1e-9 Schizophrenia; CRC cis rs2282802 0.685 rs2053055 chr5:139646776 C/T cg26211634 chr5:139558579 C5orf32 0.41 6.95 0.36 1.95e-11 Intelligence (multi-trait analysis); CRC cis rs2839186 0.647 rs9976233 chr21:47616913 G/A cg13012494 chr21:47604986 C21orf56 -0.48 -7.78 -0.39 9.72e-14 Testicular germ cell tumor; CRC cis rs12403795 0.527 rs114286538 chr1:150269177 A/T cg17724175 chr1:150552817 MCL1 0.64 5.89 0.31 9.62e-9 Illicit drug use; CRC cis rs6977660 0.652 rs58559474 chr7:19751569 C/T cg07541023 chr7:19748670 TWISTNB 1.14 10.62 0.51 7.57e-23 Thyroid stimulating hormone; CRC cis rs9381040 0.655 rs2268193 chr6:41024625 A/G cg09580153 chr6:41068724 NFYA;LOC221442 -0.42 -6.12 -0.32 2.71e-9 Alzheimer's disease (late onset); CRC cis rs9611565 0.649 rs202625 chr22:41827082 G/A cg06634786 chr22:41940651 POLR3H 0.72 8.0 0.4 2.21e-14 Vitiligo; CRC cis rs875971 0.660 rs801217 chr7:66010577 C/T cg11764359 chr7:65958608 NA -0.54 -8.48 -0.42 7.53e-16 Aortic root size; CRC cis rs7666738 0.962 rs17550217 chr4:98999699 T/A cg05340658 chr4:99064831 C4orf37 0.51 7.3 0.37 2.18e-12 Colonoscopy-negative controls vs population controls; CRC cis rs12699477 0.545 rs117125814 chr7:1910681 T/G cg14004847 chr7:1930337 MAD1L1 -0.43 -6.13 -0.32 2.45e-9 Testicular germ cell tumor; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg25759457 chr1:172502420 C1orf9 0.5 7.13 0.37 6.45e-12 Response to antipsychotic treatment; CRC cis rs12908161 1.000 rs62019464 chr15:85294469 T/A cg11189052 chr15:85197271 WDR73 0.58 8.43 0.42 1.1e-15 Schizophrenia; CRC cis rs780096 0.526 rs1647276 chr2:27688601 C/T cg12648201 chr2:27665141 KRTCAP3 -0.31 -6.28 -0.33 1.05e-9 Total body bone mineral density; CRC trans rs8124695 0.649 rs16985175 chr20:39011254 A/G cg15699267 chr20:61809557 MIR124-3 -0.53 -6.04 -0.32 4.19e-9 Dupuytren's disease; CRC cis rs7247513 0.897 rs12979146 chr19:12717904 C/T cg04657146 chr19:12876947 HOOK2 0.39 5.61 0.3 4.32e-8 Bipolar disorder; CRC cis rs68170813 0.559 rs77605964 chr7:106962948 G/A cg02696742 chr7:106810147 HBP1 -0.57 -6.13 -0.32 2.49e-9 Coronary artery disease; CRC cis rs4824093 0.610 rs73443974 chr22:50314316 G/A cg22709217 chr22:50311962 ALG12;CRELD2 -0.96 -9.24 -0.45 3.06e-18 Amyotrophic lateral sclerosis (sporadic); CRC cis rs10876993 0.890 rs2619441 chr12:58083015 C/A cg18357645 chr12:58087776 OS9 0.63 9.03 0.45 1.47e-17 Celiac disease or Rheumatoid arthritis; CRC cis rs7923609 0.934 rs2893919 chr10:65134778 G/A cg08743896 chr10:65200160 JMJD1C -0.4 -5.76 -0.3 1.98e-8 Educational attainment;Liver enzyme levels (alkaline phosphatase); CRC cis rs6570726 0.791 rs370654 chr6:145879005 C/G cg23711669 chr6:146136114 FBXO30 0.77 13.41 0.59 5.08e-33 Lobe attachment (rater-scored or self-reported); CRC trans rs7267979 0.933 rs2387887 chr20:25427081 G/T cg17903999 chr18:56338584 MALT1 -0.42 -6.98 -0.36 1.6e-11 Liver enzyme levels (alkaline phosphatase); CRC cis rs921968 0.643 rs645796 chr2:219389236 A/G cg02176678 chr2:219576539 TTLL4 0.48 8.0 0.4 2.09e-14 Mean corpuscular hemoglobin concentration; CRC cis rs908922 0.676 rs545418 chr1:152497338 C/T cg09873164 chr1:152488093 CRCT1 0.37 6.22 0.32 1.49e-9 Hair morphology; CRC cis rs6952808 0.692 rs12666575 chr7:2004421 C/T cg22963979 chr7:1858916 MAD1L1 -0.49 -7.09 -0.36 7.99e-12 Bipolar disorder and schizophrenia; CRC cis rs3956705 0.762 rs13311608 chr7:32999601 C/T cg05721444 chr7:32995514 FKBP9 0.45 6.62 0.34 1.44e-10 Red cell distribution width; CRC cis rs2204008 0.715 rs12815986 chr12:38343869 G/A cg13010199 chr12:38710504 ALG10B 0.45 5.74 0.3 2.15e-8 Bladder cancer; CRC cis rs1448094 0.512 rs7970081 chr12:86243392 G/T cg02569458 chr12:86230093 RASSF9 0.42 7.24 0.37 3.17e-12 Major depressive disorder; CRC cis rs477895 1.000 rs7939107 chr11:64034773 C/T cg18375707 chr11:64034959 PLCB3 0.48 6.03 0.32 4.34e-9 Mean platelet volume; CRC cis rs6942756 0.806 rs6467237 chr7:128964831 A/G cg02491457 chr7:128862824 NA -0.64 -8.73 -0.43 1.28e-16 White matter hyperintensity burden; CRC cis rs2239547 0.521 rs9682464 chr3:52888485 C/T cg18404041 chr3:52824283 ITIH1 -0.39 -7.26 -0.37 2.73e-12 Schizophrenia; CRC cis rs12893668 0.572 rs4906350 chr14:104111794 C/T cg24130564 chr14:104152367 KLC1 -0.42 -5.61 -0.3 4.36e-8 Reticulocyte count; CRC cis rs2019137 0.539 rs6755040 chr2:113981137 T/C cg07772999 chr2:113993052 PAX8;LOC440839;LOC654433 0.56 8.36 0.42 1.78e-15 Lymphocyte counts; CRC trans rs75804782 0.641 rs72987327 chr2:239359833 T/G cg01134436 chr17:81009848 B3GNTL1 0.74 6.74 0.35 7.25e-11 Morning vs. evening chronotype;Chronotype; CRC cis rs9814567 0.806 rs11927539 chr3:134319448 C/G cg06541857 chr3:134203789 ANAPC13;CEP63 -0.37 -5.72 -0.3 2.42e-8 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs7197653 0.748 rs58542611 chr16:68350219 C/T cg09835421 chr16:68378352 PRMT7 -0.73 -7.54 -0.38 4.5e-13 Magnesium levels; CRC cis rs2380220 0.574 rs9374322 chr6:95998994 G/A cg04719120 chr6:96025338 MANEA 0.52 6.43 0.33 4.56e-10 Behavioural disinhibition (generation interaction); CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg26260149 chr4:20701950 PACRGL 0.44 6.04 0.32 4.09e-9 Anxiety disorder; CRC cis rs7666738 0.830 rs13110498 chr4:98959150 G/A cg05340658 chr4:99064831 C4orf37 0.61 9.54 0.47 3.45e-19 Colonoscopy-negative controls vs population controls; CRC cis rs6754311 0.593 rs10186843 chr2:136586958 C/A cg25344623 chr2:136566232 LCT 0.32 5.89 0.31 9.62e-9 Mosquito bite size; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg08553284 chr12:4381997 CCND2 0.4 6.77 0.35 6.07e-11 Liver disease severity in Alagille syndrome; CRC cis rs77633900 0.881 rs80003765 chr15:76657075 T/A cg21673338 chr15:77095150 SCAPER -0.7 -6.06 -0.32 3.77e-9 Non-glioblastoma glioma;Glioma; CRC cis rs9814567 1.000 rs13071551 chr3:134310867 C/G cg06109529 chr3:134205091 CEP63;ANAPC13 0.83 12.18 0.56 1.98e-28 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs9660180 0.837 rs915292 chr1:1792157 A/C cg13866156 chr1:1669148 SLC35E2 -0.62 -9.4 -0.46 9.47e-19 Body mass index; CRC cis rs4713118 0.513 rs149897 chr6:28006650 A/G cg06470822 chr6:28175283 NA 0.8 12.29 0.56 8.04e-29 Parkinson's disease; CRC cis rs6904897 0.563 rs6569976 chr6:135224753 A/C cg22676075 chr6:135203613 NA 0.77 13.33 0.59 1.05e-32 Mean corpuscular volume;Mean corpuscular hemoglobin; CRC trans rs875971 0.660 rs2191268 chr7:66110224 C/T cg10780112 chr6:138725213 HEBP2 -0.43 -6.63 -0.34 1.39e-10 Aortic root size; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg01390591 chr3:143690991 C3orf58 0.46 6.27 0.33 1.13e-9 Anxiety disorder; CRC cis rs6951245 1.000 rs11763835 chr7:1094513 A/G cg03188948 chr7:1209495 NA 0.66 6.97 0.36 1.77e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs2976388 0.609 rs2164308 chr8:143785659 A/G cg24046110 chr8:143859143 LYNX1 -0.48 -8.35 -0.42 1.87e-15 Urinary tract infection frequency; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg02099313 chr1:231114956 TTC13;ARV1 0.51 6.71 0.35 8.27e-11 Thyroid stimulating hormone; CRC cis rs9399137 0.507 rs11757723 chr6:135291293 C/T cg24558204 chr6:135376177 HBS1L 0.6 8.86 0.44 5.07e-17 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; CRC trans rs7395662 0.864 rs11039872 chr11:48629533 C/T cg21153622 chr11:89784906 NA -0.44 -7.1 -0.36 7.82e-12 HDL cholesterol; CRC cis rs1865760 0.827 rs9295681 chr6:25944117 T/G cg17691542 chr6:26056736 HIST1H1C 0.52 7.65 0.39 2.24e-13 Height; CRC cis rs977987 0.806 rs4888420 chr16:75462998 G/C cg03315344 chr16:75512273 CHST6 0.55 9.25 0.45 3.01e-18 Dupuytren's disease; CRC cis rs875971 0.545 rs67688847 chr7:65626051 G/A cg03233332 chr7:66118400 NA -0.45 -6.22 -0.32 1.49e-9 Aortic root size; CRC trans rs2303319 0.504 rs12470830 chr2:162429996 C/T cg10498984 chr16:28874827 SH2B1 -0.73 -5.97 -0.31 6.13e-9 Cognitive function; CRC cis rs17767392 0.813 rs61989386 chr14:71986545 T/C cg13720639 chr14:72061746 SIPA1L1 -0.49 -6.4 -0.33 5.28e-10 Mitral valve prolapse; CRC cis rs7662987 0.517 rs2602878 chr4:100039953 T/G cg12011299 chr4:100065546 ADH4 0.49 9.25 0.45 3.02e-18 Smoking initiation; CRC trans rs16846053 0.786 rs72873645 chr2:162495047 G/A cg04269497 chr6:167369491 RNASET2 -0.71 -6.01 -0.31 4.99e-9 Blood osmolality (transformed sodium); CRC cis rs769267 0.895 rs2916073 chr19:19528324 T/G cg01262667 chr19:19385393 TM6SF2 0.37 6.23 0.33 1.39e-9 Tonsillectomy; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg02317742 chr2:85981021 ATOH8 0.47 6.59 0.34 1.7e-10 Response to antipsychotic treatment; CRC cis rs16975963 0.644 rs59426132 chr19:38092770 T/G cg15135657 chr19:38346511 NA -0.43 -6.02 -0.31 4.66e-9 Longevity; CRC cis rs1707322 1.000 rs12077546 chr1:46431806 C/T cg03146154 chr1:46216737 IPP 0.51 7.09 0.36 8.01e-12 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs2629540 0.855 rs12776722 chr10:126469833 G/A cg08799069 chr10:126477246 METTL10 0.63 7.95 0.4 3.01e-14 Cocaine dependence; CRC cis rs9549367 0.664 rs9549689 chr13:113848387 G/A cg18105134 chr13:113819100 PROZ -0.88 -12.74 -0.57 1.69e-30 Platelet distribution width; CRC cis rs13382862 0.862 rs340595 chr2:20889714 A/G cg12334488 chr2:20871173 GDF7 -0.34 -6.35 -0.33 7.07e-10 Abdominal aortic aneurysm; CRC cis rs801193 1.000 rs3800812 chr7:66223461 T/C cg00343986 chr7:65444356 GUSB 0.49 7.32 0.37 1.92e-12 Aortic root size; CRC cis rs34779708 0.898 rs4934695 chr10:35280605 C/T cg03585969 chr10:35415529 CREM 0.66 8.82 0.44 6.68e-17 Inflammatory bowel disease;Crohn's disease; CRC cis rs1862618 0.671 rs28397234 chr5:56248428 T/G cg24531977 chr5:56204891 C5orf35 0.66 10.26 0.49 1.29e-21 Initial pursuit acceleration; CRC cis rs12410462 1.000 rs6672162 chr1:227632335 G/A cg23173402 chr1:227635558 NA 0.7 7.96 0.4 2.83e-14 Major depressive disorder; CRC cis rs853679 0.517 rs11552219 chr6:28126834 C/T cg02683197 chr6:28174875 NA 0.87 10.73 0.51 3.25e-23 Depression; CRC cis rs6088580 0.634 rs6087579 chr20:32985155 A/G cg24642439 chr20:33292090 TP53INP2 -0.37 -6.29 -0.33 9.83e-10 Glomerular filtration rate (creatinine); CRC cis rs3806843 0.868 rs2563291 chr5:140119599 T/A cg16607685 chr5:140181889 PCDHA2;PCDHA1;PCDHA3 0.25 6.01 0.31 5.05e-9 Depressive symptoms (multi-trait analysis); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg21436751 chr20:18118344 PET117 0.44 6.08 0.32 3.35e-9 Response to antipsychotic treatment; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg06648271 chr10:126432949 FAM53B 0.43 6.26 0.33 1.21e-9 Response to antipsychotic treatment; CRC cis rs1018836 0.923 rs2157607 chr8:91600268 A/G cg16814680 chr8:91681699 NA -0.76 -11.65 -0.54 1.7e-26 Ejection fraction in Tripanosoma cruzi seropositivity; CRC trans rs4873772 0.800 rs4873478 chr8:48523296 C/G cg05343739 chr1:154731938 KCNN3 0.35 6.13 0.32 2.55e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs9462027 0.606 rs2814979 chr6:34578425 G/C cg07306190 chr6:34760872 UHRF1BP1 -0.35 -6.1 -0.32 2.91e-9 Systemic lupus erythematosus; CRC cis rs6951245 0.678 rs28600085 chr7:1169636 C/T cg26224354 chr7:1096374 C7orf50;GPR146 -0.82 -10.97 -0.52 4.39e-24 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs769267 0.896 rs7253807 chr19:19631444 A/T cg03709012 chr19:19516395 GATAD2A 0.69 10.69 0.51 4.27e-23 Tonsillectomy; CRC cis rs10927875 0.518 rs1763597 chr1:16343297 C/T cg22431228 chr1:16359049 CLCNKA -0.38 -6.91 -0.36 2.52e-11 Dilated cardiomyopathy; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg16854524 chr4:83931902 LIN54 0.46 6.03 0.32 4.36e-9 Thyroid stimulating hormone; CRC cis rs72781680 0.898 rs6712175 chr2:24023431 T/G cg08917208 chr2:24149416 ATAD2B 0.86 8.58 0.43 3.88e-16 Lymphocyte counts; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg02124459 chr5:141256135 PCDH1 0.5 6.73 0.35 7.44e-11 Thyroid stimulating hormone; CRC cis rs7120118 0.517 rs3758671 chr11:47273089 G/C cg25783544 chr11:47291846 MADD 0.64 5.77 0.3 1.85e-8 HDL cholesterol; CRC cis rs113835537 0.935 rs3867133 chr11:66451962 A/G cg22134325 chr11:66188745 NPAS4 -0.33 -5.72 -0.3 2.41e-8 Airway imaging phenotypes; CRC cis rs6662572 0.737 rs7533750 chr1:46558434 G/C cg03123370 chr1:45965343 CCDC163P;MMACHC 0.48 6.26 0.33 1.22e-9 Blood protein levels; CRC cis rs6951245 0.706 rs28685743 chr7:1197736 C/T cg04025307 chr7:1156635 C7orf50 0.61 6.78 0.35 5.47e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs11628318 0.853 rs7140280 chr14:103026991 C/T cg12046867 chr14:103022105 NA -0.63 -8.66 -0.43 2.18e-16 Platelet count; CRC cis rs13191362 0.872 rs13215538 chr6:163037975 T/C cg23758597 chr6:163146217 PARK2 -0.62 -6.2 -0.32 1.65e-9 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs7617773 0.563 rs13082269 chr3:48392274 G/A cg11946769 chr3:48343235 NME6 0.61 8.32 0.42 2.43e-15 Coronary artery disease; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg04510639 chr17:74722764 JMJD6;C17orf95 0.4 6.31 0.33 8.81e-10 Liver disease severity in Alagille syndrome; CRC cis rs832540 0.603 rs6870175 chr5:56093371 A/G cg20203395 chr5:56204925 C5orf35 -0.47 -6.46 -0.34 3.73e-10 Coronary artery disease; CRC cis rs1223397 0.938 rs3817741 chr6:13279507 A/G cg00460589 chr6:13274354 PHACTR1 -0.46 -5.94 -0.31 7.43e-9 Blood pressure; CRC cis rs2933343 0.621 rs4927921 chr3:128568868 A/G cg11901034 chr3:128598214 ACAD9 0.52 7.6 0.39 3.03e-13 IgG glycosylation; CRC cis rs758324 0.812 rs11242095 chr5:131152575 A/G cg25547332 chr5:131281432 NA 0.36 5.78 0.3 1.7e-8 Alzheimer's disease in APOE e4- carriers; CRC cis rs6502050 0.835 rs10163496 chr17:80110867 G/A cg11859384 chr17:80120422 CCDC57 -0.37 -5.85 -0.31 1.16e-8 Life satisfaction; CRC cis rs887829 0.570 rs10203266 chr2:234596368 G/C cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.47 -7.31 -0.37 2.05e-12 Metabolic traits;Bilirubin levels;Cholelithiasis-related traits in sickle cell anemia;Metabolite levels;Total bilirubin levels in HIV-1 infection;Serum metabolite levels;Blood metabolite levels; CRC cis rs10791097 0.547 rs12365680 chr11:130749059 C/T cg12179176 chr11:130786555 SNX19 0.76 12.74 0.57 1.77e-30 Autism spectrum disorder or schizophrenia;Schizophrenia; CRC cis rs1707322 0.752 rs28568986 chr1:46207743 C/T cg03146154 chr1:46216737 IPP 0.68 9.85 0.48 3.13e-20 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs2415984 0.579 rs2642091 chr14:46972754 A/G cg14871534 chr14:47121158 RPL10L 0.38 5.65 0.3 3.43e-8 Number of children ever born; CRC cis rs11122272 0.735 rs2437150 chr1:231488524 A/G cg06096015 chr1:231504339 EGLN1 -0.37 -5.63 -0.3 3.96e-8 Hemoglobin concentration; CRC cis rs6960043 0.818 rs10950550 chr7:15063923 T/G cg19272540 chr7:15055459 NA 0.23 6.01 0.31 4.81e-9 Type 2 diabetes; CRC cis rs4731207 0.564 rs6967420 chr7:124609360 C/T cg23710748 chr7:124431027 NA -0.39 -6.23 -0.32 1.46e-9 Cutaneous malignant melanoma; CRC cis rs736801 0.808 rs2706403 chr5:131799012 A/G cg02033258 chr5:131593261 PDLIM4 -0.34 -5.96 -0.31 6.66e-9 Breast cancer;Mosquito bite size; CRC trans rs1005277 0.579 rs2472182 chr10:38388865 T/C cg11292332 chr7:45801988 SEPT13 -0.35 -6.26 -0.33 1.18e-9 Extrinsic epigenetic age acceleration; CRC cis rs5750830 0.649 rs4384886 chr22:39793766 C/T cg24399712 chr22:39784796 NA -0.53 -11.41 -0.53 1.25e-25 Intelligence (multi-trait analysis); CRC cis rs6977940 0.512 rs11765726 chr7:2850878 A/G cg19731401 chr7:2775893 GNA12 0.53 5.84 0.31 1.26e-8 White matter integrity; CRC cis rs79976124 0.837 rs12194087 chr6:66644399 T/A cg07460842 chr6:66804631 NA 0.75 9.35 0.46 1.4e-18 Type 2 diabetes; CRC cis rs896854 0.812 rs2340586 chr8:95969261 G/A cg16049864 chr8:95962084 TP53INP1 -0.64 -11.63 -0.54 2e-26 Type 2 diabetes; CRC cis rs950169 0.580 rs4603535 chr15:85173872 C/T cg17507749 chr15:85114479 UBE2QP1 0.63 8.95 0.44 2.66e-17 Schizophrenia; CRC cis rs6831352 0.693 rs2602875 chr4:100039495 C/G cg13256891 chr4:100009986 ADH5 0.56 7.89 0.4 4.44e-14 Alcohol dependence; CRC cis rs10791323 0.604 rs2851116 chr11:133705759 G/A cg03690763 chr11:133734501 NA -0.35 -5.72 -0.3 2.4e-8 Childhood ear infection; CRC cis rs10504229 0.683 rs35244711 chr8:58117762 T/G cg22535103 chr8:58192502 C8orf71 -0.7 -9.34 -0.46 1.47e-18 Developmental language disorder (linguistic errors); CRC trans rs11098499 0.866 rs9995136 chr4:120286845 A/G cg25214090 chr10:38739885 LOC399744 0.61 9.66 0.47 1.39e-19 Corneal astigmatism; CRC cis rs10876993 0.826 rs1678534 chr12:58057435 A/C cg15848620 chr12:58087721 OS9 -0.65 -8.98 -0.44 2.14e-17 Celiac disease or Rheumatoid arthritis; CRC cis rs6922632 0.867 rs1343625 chr6:24112737 C/G cg26194775 chr6:24126114 NRSN1 -0.63 -7.61 -0.39 2.98e-13 Information processing speed; CRC cis rs7584330 0.554 rs3751106 chr2:238428418 G/A cg14458575 chr2:238380390 NA 0.43 6.01 0.31 4.86e-9 Prostate cancer; CRC cis rs2050392 0.630 rs303426 chr10:30740379 A/G cg25182066 chr10:30743637 MAP3K8 0.49 7.2 0.37 4.01e-12 Inflammatory bowel disease; CRC trans rs3960554 0.808 rs868555 chr7:75697418 G/A cg19862616 chr7:65841803 NCRNA00174 0.73 8.64 0.43 2.55e-16 Eotaxin levels; CRC cis rs13118159 0.550 rs2878607 chr4:1353310 G/C cg19318889 chr4:1322082 MAEA 0.71 10.49 0.5 2.17e-22 Longevity; CRC cis rs6918586 0.658 rs198819 chr6:26124430 C/T cg18357526 chr6:26021779 HIST1H4A -0.49 -7.33 -0.37 1.81e-12 Schizophrenia; CRC cis rs4713118 0.662 rs149961 chr6:28015569 A/C cg25164649 chr6:28176230 NA 0.65 8.64 0.43 2.53e-16 Parkinson's disease; CRC cis rs6543140 1.000 rs6543140 chr2:103074274 G/T cg04239558 chr2:103089729 SLC9A4 0.37 6.58 0.34 1.83e-10 Blood protein levels; CRC cis rs11112613 0.713 rs10507192 chr12:105948247 A/G cg03607813 chr12:105948248 NA 0.9 12.35 0.56 4.91e-29 Corrected insulin response;Corrected insulin response adjusted for insulin sensitivity index; CRC trans rs7726839 0.507 rs56282020 chr5:596701 T/C cg11887960 chr12:57824829 NA 0.59 6.66 0.34 1.15e-10 Obesity-related traits; CRC cis rs7086627 0.515 rs10887896 chr10:82210144 A/C cg09626299 chr10:82213104 TSPAN14 -0.37 -6.12 -0.32 2.6e-9 Post bronchodilator FEV1; CRC cis rs2836974 0.897 rs2836932 chr21:40546717 G/A cg17971929 chr21:40555470 PSMG1 0.81 11.76 0.54 6.78e-27 Cognitive function; CRC cis rs8014204 0.935 rs2300596 chr14:75353855 C/T cg03030879 chr14:75389066 RPS6KL1 -0.53 -8.61 -0.43 3.04e-16 Caffeine consumption; CRC cis rs7666738 0.830 rs2903150 chr4:99027184 T/C cg17366294 chr4:99064904 C4orf37 0.44 7.48 0.38 6.96e-13 Colonoscopy-negative controls vs population controls; CRC cis rs6582630 0.500 rs35251810 chr12:38577666 T/C cg26384229 chr12:38710491 ALG10B -0.53 -7.67 -0.39 1.94e-13 Drug-induced liver injury (flucloxacillin); CRC cis rs7412746 0.658 rs11204739 chr1:150865760 A/G cg10589385 chr1:150898437 SETDB1 0.34 7.28 0.37 2.49e-12 Melanoma; CRC cis rs9399137 0.507 rs7754722 chr6:135260303 T/C cg24558204 chr6:135376177 HBS1L -0.59 -8.58 -0.43 3.9e-16 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; CRC cis rs73206853 0.841 rs56017468 chr12:110653857 T/C cg12870014 chr12:110450643 ANKRD13A 0.79 7.63 0.39 2.58e-13 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC cis rs4332037 0.539 rs11764780 chr7:2020904 G/C cg25834613 chr7:1915315 MAD1L1 -0.48 -6.87 -0.35 3.21e-11 Bipolar disorder; CRC cis rs644799 0.965 rs502521 chr11:95533557 T/A cg03916912 chr11:95522834 CEP57;FAM76B 0.93 17.68 0.7 1.19e-49 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs6748734 1.000 rs4311055 chr2:241821017 T/C cg04034577 chr2:241836375 C2orf54 -0.41 -8.79 -0.44 8.21e-17 Urinary metabolites; CRC cis rs9372498 0.536 rs9481821 chr6:118846022 A/C cg22561889 chr6:118971681 C6orf204 0.49 6.31 0.33 9.17e-10 Diastolic blood pressure; CRC cis rs3820068 0.581 rs74054797 chr1:15926217 G/A cg24675056 chr1:15929824 NA 0.49 6.66 0.34 1.12e-10 Systolic blood pressure; CRC cis rs1395 0.744 rs4665962 chr2:27515105 A/G cg14242246 chr2:27434262 C2orf28;SLC5A6 0.35 5.82 0.31 1.44e-8 Blood metabolite levels; CRC cis rs4728302 0.869 rs10808273 chr7:133597691 G/C cg03336402 chr7:133662267 EXOC4 -0.45 -6.5 -0.34 2.97e-10 Intelligence;Intelligence (multi-trait analysis); CRC cis rs2153535 0.601 rs9328487 chr6:8529378 G/C cg21535247 chr6:8435926 SLC35B3 0.49 7.45 0.38 8.34e-13 Motion sickness; CRC cis rs734999 0.588 rs2764841 chr1:2529360 G/A cg18854424 chr1:2615690 NA -0.5 -9.91 -0.48 2.03e-20 Ulcerative colitis; CRC cis rs4713118 0.955 rs9380010 chr6:27683572 A/G cg15845792 chr6:28175446 NA 0.6 7.95 0.4 3.01e-14 Parkinson's disease; CRC trans rs6819266 0.636 rs13148734 chr4:63330858 A/G cg13627451 chr15:52043674 TMOD2;LYSMD2 0.37 6.05 0.32 3.88e-9 Age-related macular degeneration; CRC trans rs1814175 0.935 rs6485999 chr11:49658986 G/C cg11707556 chr5:10655725 ANKRD33B -0.42 -7.73 -0.39 1.35e-13 Height; CRC cis rs7224685 0.569 rs7215798 chr17:4007666 C/G cg09695851 chr17:3907499 NA -0.5 -6.2 -0.32 1.67e-9 Type 2 diabetes; CRC cis rs7674212 0.539 rs6854709 chr4:104129786 A/G cg16532752 chr4:104119610 CENPE -0.4 -5.68 -0.3 2.91e-8 Type 2 diabetes; CRC trans rs78049276 0.512 rs6855875 chr4:148402737 C/T cg13149281 chr14:23389818 RBM23;PRMT5 -0.49 -6.42 -0.33 4.65e-10 Pulse pressure; CRC cis rs7772486 0.875 rs1412081 chr6:146409733 A/G cg23711669 chr6:146136114 FBXO30 0.66 11.41 0.53 1.29e-25 Lobe attachment (rater-scored or self-reported); CRC trans rs916888 0.773 rs9896243 chr17:44826056 C/G cg01341218 chr17:43662625 NA 0.89 9.38 0.46 1.13e-18 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs6964587 1.000 rs6960867 chr7:91712698 A/G cg17063962 chr7:91808500 NA 0.67 10.71 0.51 3.67e-23 Breast cancer; CRC cis rs9311676 0.656 rs34579268 chr3:58410554 C/T cg06643156 chr3:58380774 PXK 0.42 6.38 0.33 5.84e-10 Systemic lupus erythematosus; CRC cis rs8060686 0.920 rs2292318 chr16:67985706 C/T cg07125278 chr16:67683757 RLTPR -0.57 -6.08 -0.32 3.36e-9 HDL cholesterol;Metabolic syndrome; CRC cis rs1577917 1.000 rs1911553 chr6:86630892 T/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.51 -6.74 -0.35 7.09e-11 Response to antipsychotic treatment; CRC cis rs4662945 0.724 rs4427966 chr2:130221148 G/A cg05962382 chr2:130345044 NA -0.34 -5.87 -0.31 1.06e-8 Response to cytidine analogues (gemcitabine); CRC trans rs1814175 0.817 rs7932683 chr11:49983640 G/A cg11707556 chr5:10655725 ANKRD33B -0.44 -8.34 -0.42 2.03e-15 Height; CRC cis rs12477438 0.798 rs1349779 chr2:99645055 T/C cg14399236 chr2:99771627 LIPT1;TSGA10 -0.75 -10.56 -0.5 1.22e-22 Chronic sinus infection; CRC cis rs6597981 0.604 rs7945912 chr11:750849 A/T cg01741372 chr11:783889 NA 0.52 8.79 0.44 8.43e-17 Breast cancer; CRC cis rs2739330 0.760 rs5751761 chr22:24243736 A/G cg10150615 chr22:24372951 LOC391322 0.51 7.41 0.38 1.08e-12 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs853679 0.546 rs200977 chr6:27854301 T/C cg26587870 chr6:27730563 NA -0.63 -6.09 -0.32 3.1e-9 Depression; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg01061575 chr22:45098367 PRR5-ARHGAP8;PRR5 0.48 6.79 0.35 5.19e-11 Response to antipsychotic treatment; CRC trans rs7819412 0.875 rs11250121 chr8:11060311 A/C cg16141378 chr3:129829833 LOC729375 0.41 6.05 0.32 3.98e-9 Triglycerides; CRC cis rs6540559 0.673 rs6540561 chr1:209982255 C/T cg21951975 chr1:209979733 IRF6 0.48 6.54 0.34 2.34e-10 Cleft lip with or without cleft palate; CRC cis rs7538876 0.935 rs11577822 chr1:17754608 T/G cg07965774 chr1:17746286 RCC2 0.33 6.17 0.32 1.95e-9 Basal cell carcinoma; CRC cis rs514406 0.505 rs6688064 chr1:53165609 C/T cg25767906 chr1:53392781 SCP2 -0.38 -5.84 -0.31 1.26e-8 Monocyte count; CRC cis rs769267 0.930 rs2315022 chr19:19413381 A/G cg02546618 chr19:19431379 KIAA0892;SF4 0.46 6.3 0.33 9.47e-10 Tonsillectomy; CRC cis rs763121 0.853 rs4821809 chr22:39065743 G/C cg06544989 chr22:39130855 UNC84B 0.46 7.17 0.37 5.11e-12 Menopause (age at onset); CRC cis rs10504229 0.679 rs11783963 chr8:58130496 T/A cg05313129 chr8:58192883 C8orf71 -0.43 -6.11 -0.32 2.74e-9 Developmental language disorder (linguistic errors); CRC cis rs1355223 1.000 rs1396879 chr11:34766653 A/C cg11058730 chr11:34937778 PDHX;APIP -0.46 -6.58 -0.34 1.88e-10 Systemic lupus erythematosus and Systemic sclerosis; CRC trans rs3736594 0.559 rs62141292 chr2:27784300 A/C cg02184673 chr11:123066560 ASAM 0.3 6.06 0.32 3.66e-9 Fasting blood glucose;Fasting blood glucose (BMI interaction); CRC cis rs5751901 0.688 rs2017869 chr22:24997309 C/G cg08808123 chr22:24999002 GGT1 -0.39 -5.9 -0.31 9.19e-9 Protein quantitative trait loci; CRC cis rs9513627 0.512 rs9517759 chr13:100180108 T/G cg15490075 chr13:100150979 NA 0.56 6.45 0.34 3.97e-10 Obesity-related traits; CRC cis rs1008375 1.000 rs6449323 chr4:17683916 A/T cg16339924 chr4:17578868 LAP3 0.53 7.22 0.37 3.63e-12 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs4665809 0.531 rs3892649 chr2:26457267 T/G cg26119090 chr2:26468346 HADHA;HADHB 1.06 15.53 0.65 3.62e-41 Gut microbiome composition (summer); CRC cis rs17711722 0.701 rs781143 chr7:65439879 G/C cg18876405 chr7:65276391 NA 0.66 12.14 0.56 2.88e-28 Calcium levels; CRC cis rs7586879 0.616 rs6545809 chr2:25126715 C/T cg22495460 chr2:25135724 ADCY3 -0.87 -16.95 -0.68 9.6e-47 Body mass index; CRC cis rs6558530 0.692 rs6558521 chr8:1700818 C/T cg19131313 chr8:1704013 NA 0.49 5.8 0.3 1.52e-8 Systolic blood pressure; CRC cis rs73206853 0.686 rs73194018 chr12:111127697 G/A cg12870014 chr12:110450643 ANKRD13A 0.63 5.79 0.3 1.6e-8 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC cis rs11655198 1 rs11655198 chr17:38026169 C/T cg00129232 chr17:37814104 STARD3 -0.48 -7.76 -0.39 1.05e-13 Asthma; CRC trans rs10838798 0.523 rs11039593 chr11:48240112 A/G cg15704280 chr7:45808275 SEPT13 -0.47 -6.55 -0.34 2.19e-10 Height; CRC cis rs10769945 0.679 rs7105710 chr11:1918083 T/C cg23202291 chr11:1979235 NA 0.42 6.11 0.32 2.88e-9 DNA methylation (variation); CRC cis rs1799949 1.000 rs12942277 chr17:41187974 G/C cg05368731 chr17:41323189 NBR1 0.67 9.58 0.47 2.42e-19 Menopause (age at onset); CRC trans rs853679 0.824 rs34712084 chr6:28043828 A/G cg06606381 chr12:133084897 FBRSL1 -0.95 -8.06 -0.41 1.38e-14 Depression; CRC cis rs35883536 1.000 rs1577504 chr1:101123913 A/T cg14515779 chr1:101123966 NA -0.44 -8.65 -0.43 2.35e-16 Monocyte count; CRC cis rs7131987 0.903 rs10843367 chr12:29408380 G/A cg09582351 chr12:29534625 ERGIC2 -0.33 -7.11 -0.37 7.07e-12 QT interval; CRC cis rs2243480 0.901 rs2949697 chr7:65464236 A/G cg18252515 chr7:66147081 NA -1.06 -12.27 -0.56 9.34e-29 Diabetic kidney disease; CRC cis rs28386778 0.863 rs11649912 chr17:61797515 T/A cg11494091 chr17:61959527 GH2 0.58 9.83 0.48 3.67e-20 Prudent dietary pattern; CRC cis rs6867032 0.958 rs4505990 chr5:2015811 A/G cg26168224 chr5:2018326 NA 1.0 18.47 0.71 9.02e-53 Gut microbiome composition (winter); CRC trans rs9825823 0.617 rs2083264 chr3:61074229 A/G cg21574204 chr6:28048958 ZNF165 0.4 5.97 0.31 6.03e-9 Depressive symptom measurement or major depressive disorder; CRC cis rs2836974 0.932 rs35571600 chr21:40590624 A/C cg11890956 chr21:40555474 PSMG1 1.11 19.3 0.73 4.74e-56 Cognitive function; CRC cis rs17401966 1.000 rs1536263 chr1:10378914 T/C cg19773385 chr1:10388646 KIF1B -0.58 -7.88 -0.4 4.8e-14 Hepatocellular carcinoma; CRC cis rs728616 0.614 rs17678338 chr10:82098146 C/T cg11900509 chr10:81946545 ANXA11 -0.56 -6.33 -0.33 8.22e-10 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs1862618 0.853 rs866222 chr5:56184444 T/C cg20203395 chr5:56204925 C5orf35 -0.72 -8.29 -0.42 2.99e-15 Initial pursuit acceleration; CRC cis rs9467603 0.925 rs1954598 chr6:25776060 T/C cg08501292 chr6:25962987 TRIM38 -0.95 -8.23 -0.41 4.57e-15 Intelligence (multi-trait analysis); CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg27574256 chr1:52607756 ZFYVE9 0.48 6.79 0.35 5.3e-11 Anxiety disorder; CRC cis rs7517126 1.000 rs6428366 chr1:196844167 C/T cg13682187 chr1:196946512 CFHR5 0.35 5.68 0.3 2.95e-8 Blood protein levels; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg17231661 chr11:119039801 NLRX1 0.39 6.01 0.31 4.88e-9 Intelligence (multi-trait analysis); CRC cis rs10751667 0.666 rs7395182 chr11:927553 A/C cg01483505 chr11:975446 AP2A2 0.43 6.87 0.35 3.26e-11 Alzheimer's disease (late onset); CRC cis rs9291683 0.588 rs2240724 chr4:10021290 G/C cg00071950 chr4:10020882 SLC2A9 0.67 12.98 0.58 2.23e-31 Bone mineral density; CRC cis rs7613875 0.641 rs6446194 chr3:50067298 T/A cg24308560 chr3:49941425 MST1R 0.43 6.79 0.35 5.22e-11 Body mass index; CRC cis rs7107174 0.688 rs11237490 chr11:78135229 C/T cg02023728 chr11:77925099 USP35 0.39 5.94 0.31 7.11e-9 Testicular germ cell tumor; CRC cis rs832540 0.556 rs4146565 chr5:56093825 T/C cg20203395 chr5:56204925 C5orf35 -0.48 -6.54 -0.34 2.38e-10 Coronary artery disease; CRC cis rs8022179 0.566 rs959083 chr14:103822687 A/G cg12935359 chr14:103987150 CKB -0.44 -5.6 -0.3 4.45e-8 Monocyte count; CRC cis rs9903692 0.954 rs7217496 chr17:46154202 A/G cg21215337 chr17:46176117 CBX1 0.42 7.79 0.39 8.93e-14 Pulse pressure; CRC trans rs7937682 0.924 rs6589244 chr11:111534333 T/C cg18187862 chr3:45730750 SACM1L 0.51 7.38 0.38 1.32e-12 Primary sclerosing cholangitis; CRC cis rs9584850 0.834 rs9584855 chr13:99119000 G/T cg20487152 chr13:99095054 FARP1 -0.39 -5.92 -0.31 8.23e-9 Neuroticism; CRC cis rs4713118 0.662 rs9380046 chr6:28030499 T/C cg15845792 chr6:28175446 NA 0.95 13.61 0.6 8.98e-34 Parkinson's disease; CRC cis rs12620999 0.555 rs4078064 chr2:238110296 C/T cg15867307 chr2:238110829 NA 0.44 7.23 0.37 3.34e-12 Systemic lupus erythematosus; CRC cis rs6502050 0.799 rs12603050 chr17:80104631 A/G cg19223190 chr17:80058835 NA 0.4 6.36 0.33 6.88e-10 Life satisfaction; CRC cis rs6496667 1.000 rs7178663 chr15:90897058 C/T cg04176472 chr15:90893244 GABARAPL3 0.62 8.5 0.42 6.52e-16 Rheumatoid arthritis; CRC cis rs11690935 0.959 rs7597387 chr2:172577116 T/C cg13550731 chr2:172543902 DYNC1I2 -1.06 -18.65 -0.72 1.83e-53 Schizophrenia; CRC cis rs738322 0.775 rs13056506 chr22:38580917 G/T cg25457927 chr22:38595422 NA 0.45 9.95 0.48 1.49e-20 Cutaneous nevi; CRC cis rs4713118 0.586 rs6905522 chr6:28086479 A/C cg21251018 chr6:28226885 NKAPL 0.48 6.19 0.32 1.84e-9 Parkinson's disease; CRC cis rs9359856 0.510 rs2748298 chr6:90436877 A/C cg13799429 chr6:90582589 CASP8AP2 -0.78 -10.24 -0.49 1.49e-21 Bipolar disorder; CRC cis rs11190604 1.000 rs11190558 chr10:102209397 C/A cg07080220 chr10:102295463 HIF1AN 0.47 5.79 0.3 1.63e-8 Palmitoleic acid (16:1n-7) levels; CRC cis rs25422 0.938 rs62421538 chr6:118729703 A/T cg18833306 chr6:118973337 C6orf204 0.44 5.71 0.3 2.53e-8 Renal cell carcinoma; CRC cis rs875971 0.545 rs35459055 chr7:65944386 G/A cg18876405 chr7:65276391 NA 0.45 6.29 0.33 9.96e-10 Aortic root size; CRC cis rs7208859 0.524 rs8069400 chr17:29075967 G/T cg13385521 chr17:29058706 SUZ12P 0.71 7.64 0.39 2.36e-13 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs1691799 0.867 rs1168339 chr12:66759236 T/G cg16791601 chr12:66731901 HELB -0.73 -12.82 -0.58 8.7e-31 White blood cell count (basophil); CRC cis rs11191205 0.644 rs10883667 chr10:103384849 A/T cg15320455 chr10:103880129 LDB1 0.54 6.01 0.31 5.02e-9 Intelligence (multi-trait analysis); CRC cis rs9814567 1.000 rs7433663 chr3:134235790 A/G cg06109529 chr3:134205091 CEP63;ANAPC13 -0.82 -12.18 -0.56 2.02e-28 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC trans rs9825823 0.617 rs2083264 chr3:61074229 A/G cg24861191 chr19:2740086 SLC39A3 0.43 5.97 0.31 6.17e-9 Depressive symptom measurement or major depressive disorder; CRC trans rs4586057 0.671 rs12261011 chr10:92580807 A/G cg26894278 chr13:21016241 CRYL1 0.4 5.99 0.31 5.63e-9 Economic and political preferences (time); CRC cis rs9649213 0.574 rs7794187 chr7:97889758 A/C cg00277769 chr7:97922759 BAIAP2L1 -0.57 -9.76 -0.47 6.09e-20 Prostate cancer (SNP x SNP interaction); CRC cis rs6681460 0.649 rs6691033 chr1:67007429 C/T cg02459107 chr1:67143332 SGIP1 0.37 5.78 0.3 1.77e-8 Presence of antiphospholipid antibodies; CRC cis rs1707322 1.000 rs12097761 chr1:46291162 T/C cg06784218 chr1:46089804 CCDC17 0.6 10.78 0.51 2.09e-23 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs17270561 0.609 rs1892254 chr6:25750530 T/C cg17691542 chr6:26056736 HIST1H1C 0.7 8.57 0.43 4.08e-16 Iron status biomarkers; CRC trans rs453301 0.686 rs11785634 chr8:8892597 G/T cg16141378 chr3:129829833 LOC729375 0.43 6.48 0.34 3.37e-10 Joint mobility (Beighton score); CRC cis rs709400 0.628 rs2273699 chr14:103923475 A/G cg12935359 chr14:103987150 CKB -0.48 -7.76 -0.39 1.05e-13 Body mass index; CRC cis rs1129187 0.755 rs2274514 chr6:42934500 C/T cg10862848 chr6:42927986 GNMT -0.39 -9.43 -0.46 7.53e-19 Alzheimer's disease in APOE e4+ carriers; CRC cis rs1552244 1.000 rs35993975 chr3:10067794 A/G cg16606324 chr3:10149918 C3orf24 0.68 7.93 0.4 3.39e-14 Alzheimer's disease; CRC cis rs1712517 0.771 rs61869827 chr10:105079439 T/C cg05636881 chr10:105038444 INA 0.45 8.01 0.4 2.02e-14 Migraine; CRC cis rs1691799 0.867 rs1168344 chr12:66758213 G/A cg16791601 chr12:66731901 HELB -0.73 -12.82 -0.58 8.7e-31 White blood cell count (basophil); CRC cis rs6831352 0.918 rs28987097 chr4:100049579 C/T cg12011299 chr4:100065546 ADH4 -0.49 -9.27 -0.45 2.61e-18 Alcohol dependence; CRC cis rs35146811 0.695 rs858509 chr7:99821470 A/G cg00553149 chr7:99775558 STAG3;GPC2 -0.25 -5.72 -0.3 2.38e-8 Coronary artery disease; CRC cis rs801193 1.000 rs1553610 chr7:66197233 T/C cg00343986 chr7:65444356 GUSB 0.49 7.26 0.37 2.9e-12 Aortic root size; CRC cis rs6964587 1.000 rs417 chr7:91581121 C/A cg17063962 chr7:91808500 NA -0.82 -14.48 -0.62 4.27e-37 Breast cancer; CRC cis rs875971 0.862 rs801194 chr7:66028495 T/C cg18876405 chr7:65276391 NA -0.52 -8.35 -0.42 1.91e-15 Aortic root size; CRC cis rs6835098 0.816 rs13111572 chr4:174159788 G/A cg08422745 chr4:174089978 GALNT7 0.95 14.6 0.63 1.42e-37 Dementia and core Alzheimer's disease neuropathologic changes; CRC cis rs637571 0.522 rs7105628 chr11:65763067 C/T cg17985854 chr11:65770987 BANF1;EIF1AD 0.53 8.69 0.43 1.79e-16 Eosinophil percentage of white cells; CRC cis rs7615952 0.576 rs2276729 chr3:125826214 G/A cg15145296 chr3:125709740 NA -0.52 -6.36 -0.33 6.63e-10 Blood pressure (smoking interaction); CRC cis rs11229555 0.645 rs11229450 chr11:58201629 G/C cg15696309 chr11:58395628 NA -0.82 -10.31 -0.49 8.59e-22 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; CRC cis rs3785574 0.962 rs13030 chr17:61908556 C/T cg06601766 chr17:61851465 DDX42;CCDC47 0.6 8.45 0.42 9.3e-16 Height; CRC cis rs7662987 0.517 rs2602876 chr4:100039535 A/T cg13256891 chr4:100009986 ADH5 0.62 8.42 0.42 1.16e-15 Smoking initiation; CRC trans rs9388451 0.626 rs3799708 chr6:126078530 C/T cg05039488 chr6:79577232 IRAK1BP1 -0.72 -12.41 -0.56 2.86e-29 Brugada syndrome; CRC cis rs28386778 0.897 rs7222189 chr17:61836372 T/C cg25654072 chr17:61904446 PSMC5;FTSJ3 0.71 11.05 0.52 2.32e-24 Prudent dietary pattern; CRC cis rs2692947 0.673 rs584811 chr2:97069879 A/G cg23100626 chr2:96804247 ASTL -0.29 -7.62 -0.39 2.7e-13 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; CRC cis rs477895 0.653 rs7102327 chr11:63908720 C/T cg05016508 chr11:63871570 FLRT1;MACROD1 0.52 6.72 0.35 8.22e-11 Mean platelet volume; CRC cis rs17021463 0.902 rs13102926 chr4:95245527 C/T cg11021082 chr4:95130006 SMARCAD1 0.47 6.9 0.36 2.71e-11 Testicular germ cell tumor; CRC cis rs57221529 0.713 rs12521091 chr5:590710 G/T cg09021430 chr5:549028 NA -0.68 -7.37 -0.38 1.41e-12 Lung disease severity in cystic fibrosis; CRC cis rs2342371 0.641 rs4916427 chr3:196094213 C/T cg15048948 chr3:196158458 UBXN7 0.53 6.38 0.33 6.18e-10 Fat distribution (HIV); CRC cis rs478304 0.651 rs10896037 chr11:65503424 A/G cg27068330 chr11:65405492 SIPA1 -0.63 -9.75 -0.47 6.92e-20 Acne (severe); CRC cis rs3820068 0.705 rs1800616 chr1:15832229 G/A cg27534772 chr1:16042836 PLEKHM2 0.42 7.03 0.36 1.19e-11 Systolic blood pressure; CRC cis rs2842992 0.724 rs4709368 chr6:160204127 C/T cg19482086 chr6:160211437 TCP1;MRPL18 -0.8 -12.92 -0.58 3.64e-31 Age-related macular degeneration (geographic atrophy); CRC cis rs1707322 0.717 rs2275086 chr1:46085879 C/G cg06784218 chr1:46089804 CCDC17 -0.66 -12.21 -0.56 1.58e-28 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs6499255 1.000 rs12446201 chr16:69815586 T/C cg15192750 chr16:69999425 NA 0.58 7.64 0.39 2.43e-13 IgE levels; CRC cis rs3809863 0.602 rs7225700 chr17:45391804 T/C cg25173405 chr17:45401733 C17orf57 -0.65 -10.18 -0.49 2.4e-21 Glaucoma (primary open-angle); CRC cis rs9381040 0.701 rs4711658 chr6:41162891 C/T cg03526776 chr6:41159608 TREML2 -0.41 -7.73 -0.39 1.34e-13 Alzheimer's disease (late onset); CRC cis rs477895 1.000 rs34292685 chr11:64049021 C/T cg04317338 chr11:64019027 PLCB3 0.59 6.19 0.32 1.79e-9 Mean platelet volume; CRC cis rs7998202 0.667 rs282568 chr13:113371938 A/G cg04656015 chr13:113407548 ATP11A -0.53 -6.04 -0.32 4.17e-9 Glycated hemoglobin levels; CRC cis rs6598163 0.700 rs12813179 chr12:132302228 C/G cg22244940 chr12:132335942 MMP17 0.4 5.86 0.31 1.12e-8 Migraine; CRC cis rs9611519 1.000 rs4820433 chr22:41607065 C/G cg03806693 chr22:41940476 POLR3H -0.45 -5.94 -0.31 7.4e-9 Neuroticism; CRC cis rs7849270 0.959 rs1410017 chr9:131913430 C/T cg13538475 chr9:131942899 NA -0.29 -5.75 -0.3 2.04e-8 Blood metabolite ratios; CRC trans rs7615952 0.932 rs3811679 chr3:125648283 A/G cg00769240 chr8:12517080 NA -0.54 -6.7 -0.35 9.27e-11 Blood pressure (smoking interaction); CRC cis rs8141797 1.000 rs5760229 chr22:24560254 C/G cg20894457 chr22:24584366 SUSD2 0.66 6.51 0.34 2.77e-10 Amyotrophic lateral sclerosis;Coronary artery disease; CRC cis rs11098499 0.708 rs1546506 chr4:120241240 T/C cg24375607 chr4:120327624 NA 0.47 7.33 0.37 1.79e-12 Corneal astigmatism; CRC cis rs9715521 0.900 rs72634623 chr4:59827419 T/C cg11281224 chr4:60001000 NA -0.38 -5.74 -0.3 2.2e-8 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs798554 0.567 rs1182190 chr7:2869391 A/G cg19717773 chr7:2847554 GNA12 -0.34 -5.81 -0.3 1.5e-8 Height; CRC cis rs7215564 0.818 rs4889776 chr17:78592385 C/T cg09596252 chr17:78655493 RPTOR 0.61 5.71 0.3 2.52e-8 Myopia (pathological); CRC cis rs7647973 0.593 rs28535523 chr3:49848414 C/T cg13072238 chr3:49761600 GMPPB 0.5 5.74 0.3 2.11e-8 Menarche (age at onset); CRC cis rs2032447 0.933 rs1540275 chr6:26036476 T/C cg18357526 chr6:26021779 HIST1H4A 0.8 12.26 0.56 1.03e-28 Intelligence (multi-trait analysis); CRC cis rs1448094 0.556 rs17345522 chr12:86169929 T/C cg19622623 chr12:86230825 RASSF9 -0.37 -5.63 -0.3 3.81e-8 Major depressive disorder; CRC cis rs7208487 0.684 rs12449852 chr17:37632088 A/G cg07936489 chr17:37558343 FBXL20 -0.93 -11.68 -0.54 1.39e-26 Primary biliary cholangitis;Glomerular filtration rate in non diabetics (creatinine); CRC cis rs2243480 0.711 rs2420172 chr7:65635341 T/C cg18252515 chr7:66147081 NA 1.23 14.37 0.62 1.07e-36 Diabetic kidney disease; CRC cis rs5753618 0.561 rs2040533 chr22:31679110 G/C cg22777020 chr22:31556080 RNF185 -0.51 -5.88 -0.31 1.03e-8 Colorectal cancer; CRC trans rs561341 1.000 rs72823789 chr17:30284084 G/A cg20587970 chr11:113659929 NA -1.42 -20.2 -0.74 1.43e-59 Hip circumference adjusted for BMI; CRC cis rs4862750 0.914 rs6814259 chr4:187872337 T/C cg07414643 chr4:187882934 NA 0.37 6.47 0.34 3.47e-10 Lobe attachment (rater-scored or self-reported); CRC cis rs798554 0.797 rs798486 chr7:2803037 A/G cg04166393 chr7:2884313 GNA12 0.5 6.76 0.35 6.24e-11 Height; CRC cis rs77633900 0.614 rs280030 chr15:77026853 T/C cg21673338 chr15:77095150 SCAPER -0.75 -7.94 -0.4 3.29e-14 Non-glioblastoma glioma;Glioma; CRC cis rs6500395 0.962 rs1477135 chr16:48726823 C/T cg04672837 chr16:48644449 N4BP1 0.43 6.07 0.32 3.6e-9 Response to tocilizumab in rheumatoid arthritis; CRC cis rs6831352 0.918 rs34071486 chr4:100051087 A/G cg12011299 chr4:100065546 ADH4 -0.49 -9.27 -0.45 2.61e-18 Alcohol dependence; CRC cis rs4743820 0.503 rs10991791 chr9:93921505 T/C cg14446406 chr9:93919335 NA -0.48 -8.43 -0.42 1.12e-15 Ulcerative colitis;Inflammatory bowel disease; CRC cis rs709400 1.000 rs61995780 chr14:104120612 A/G cg12935359 chr14:103987150 CKB -0.4 -6.56 -0.34 2.09e-10 Body mass index; CRC cis rs860295 0.702 rs12746592 chr1:155505967 G/A cg02153340 chr1:155202674 NA -0.58 -6.82 -0.35 4.35e-11 Body mass index; CRC cis rs10046574 0.519 rs7810403 chr7:135216172 G/A cg27474649 chr7:135195673 CNOT4 0.61 5.81 0.31 1.44e-8 Peripheral arterial disease (traffic-related air pollution interaction); CRC trans rs7267979 1.000 rs2257982 chr20:25269630 A/G cg17903999 chr18:56338584 MALT1 -0.41 -6.89 -0.36 2.82e-11 Liver enzyme levels (alkaline phosphatase); CRC cis rs4689592 0.554 rs3822270 chr4:7069804 C/A cg19539972 chr4:7069911 GRPEL1 0.77 9.92 0.48 1.82e-20 Monocyte percentage of white cells; CRC cis rs477895 0.653 rs11606544 chr11:63896901 C/T cg23719950 chr11:63933701 MACROD1 -0.65 -8.25 -0.41 3.86e-15 Mean platelet volume; CRC cis rs25645 0.792 rs8077456 chr17:38128765 C/G cg17467752 chr17:38218738 THRA -0.45 -6.53 -0.34 2.49e-10 Myeloid white cell count; CRC cis rs7916697 0.628 rs10998036 chr10:70016678 C/G cg06988349 chr10:69991859 ATOH7 -0.37 -6.72 -0.35 8.21e-11 Optic disc area; CRC trans rs9784649 1.000 rs11738315 chr5:24967891 T/C cg08600765 chr20:34638493 LOC647979 -0.59 -7.27 -0.37 2.69e-12 Peripheral arterial disease (traffic-related air pollution interaction); CRC trans rs10506458 1.000 rs12580997 chr12:63433420 G/A cg03429785 chr15:59498649 MYO1E;LDHAL6B -1.32 -18.73 -0.72 8.93e-54 Hemostatic factors and hematological phenotypes; CRC cis rs6502050 0.787 rs11653012 chr17:80058857 C/T cg22110888 chr17:80059540 CCDC57 -0.45 -7.33 -0.37 1.8e-12 Life satisfaction; CRC cis rs4629710 0.645 rs35561719 chr6:131551244 G/A cg12606694 chr6:131520996 AKAP7 0.55 8.16 0.41 7.08e-15 Multiple myeloma (IgH translocation); CRC cis rs9611565 0.840 rs9607799 chr22:41777558 A/G cg03806693 chr22:41940476 POLR3H -1.02 -13.04 -0.58 1.24e-31 Vitiligo; CRC cis rs6938 0.534 rs11072512 chr15:75204026 C/T cg14664628 chr15:75095509 CSK -0.64 -9.9 -0.48 2.21e-20 Breast cancer; CRC cis rs875971 0.862 rs778707 chr7:65857027 G/A cg00343986 chr7:65444356 GUSB 0.45 6.22 0.32 1.52e-9 Aortic root size; CRC trans rs8073060 0.544 rs225274 chr17:33971221 C/T cg19694781 chr19:47549865 TMEM160 0.9 12.54 0.57 9.42e-30 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; CRC trans rs561341 0.824 rs1978115 chr17:30220776 A/C cg20587970 chr11:113659929 NA -0.99 -11.76 -0.54 6.91e-27 Hip circumference adjusted for BMI; CRC cis rs1949733 1.000 rs2631745 chr4:8490530 T/C cg11789530 chr4:8429930 ACOX3 -0.84 -12.75 -0.58 1.56e-30 Response to antineoplastic agents; CRC cis rs7309 0.935 rs10930013 chr2:162070325 G/A cg13854012 chr2:162103682 NA -0.47 -7.54 -0.38 4.65e-13 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Educational attainment; CRC cis rs10208940 0.764 rs6737302 chr2:68782837 A/G cg12452813 chr2:68675892 NA 0.47 5.9 0.31 9.19e-9 Urate levels in lean individuals; CRC cis rs7666738 0.830 rs28465658 chr4:99035866 T/C cg17366294 chr4:99064904 C4orf37 0.44 7.47 0.38 7.18e-13 Colonoscopy-negative controls vs population controls; CRC cis rs9359856 0.564 rs17584108 chr6:90458209 T/C cg13799429 chr6:90582589 CASP8AP2 -0.75 -7.58 -0.39 3.44e-13 Bipolar disorder; CRC cis rs9479482 1.000 rs9478380 chr6:150354665 A/G cg25797454 chr6:150327115 RAET1K -0.4 -6.68 -0.35 1.04e-10 Alopecia areata; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg15299721 chr4:103997510 NHEDC2 0.41 6.02 0.31 4.6e-9 Intelligence (multi-trait analysis); CRC cis rs6089584 0.850 rs6089634 chr20:60632566 T/C cg13770153 chr20:60521292 NA -0.62 -9.49 -0.46 4.71e-19 Body mass index; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg01488865 chr20:61569319 C20orf11;DIDO1 0.39 6.05 0.32 3.96e-9 Intelligence (multi-trait analysis); CRC cis rs10504073 0.584 rs1511368 chr8:49949523 A/T cg00325661 chr8:49890786 NA 0.57 10.25 0.49 1.36e-21 Blood metabolite ratios; CRC cis rs6951245 1.000 rs76388414 chr7:1100694 G/A cg18402987 chr7:1209562 NA 0.67 7.17 0.37 5.02e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs9303401 0.659 rs17822735 chr17:56620167 C/T cg02118635 chr17:56770003 RAD51C;TEX14 0.8 9.95 0.48 1.48e-20 Cognitive test performance; CRC cis rs789852 0.867 rs1773176 chr3:194316238 C/G cg21106136 chr3:194405973 FAM43A 0.68 5.91 0.31 8.71e-9 QT interval; CRC cis rs10504229 0.906 rs73607868 chr8:58172482 T/C cg24829409 chr8:58192753 C8orf71 -0.68 -11.34 -0.53 2.27e-25 Developmental language disorder (linguistic errors); CRC cis rs4434138 0.664 rs62255364 chr3:52701502 C/T cg11645453 chr3:52864694 ITIH4 0.36 6.18 0.32 1.91e-9 Intelligence (multi-trait analysis); CRC cis rs11676348 1.000 rs11676348 chr2:219010146 C/T cg00012203 chr2:219082015 ARPC2 -0.38 -5.79 -0.3 1.61e-8 Ulcerative colitis; CRC cis rs9910055 0.659 rs7214540 chr17:42256604 A/G cg19774624 chr17:42201019 HDAC5 -0.72 -11.45 -0.53 8.61e-26 Total body bone mineral density; CRC cis rs7568498 0.517 rs11678856 chr2:161925443 C/T cg16506815 chr2:162101123 NA -0.39 -5.84 -0.31 1.22e-8 Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 3 peripheral neuropathy); CRC cis rs13108904 0.905 rs1680074 chr4:1279621 G/A cg05665937 chr4:1216051 CTBP1 -0.39 -5.99 -0.31 5.58e-9 Obesity-related traits; CRC cis rs4954585 0.683 rs10221893 chr2:137013606 C/T cg05194412 chr2:137003533 NA 0.44 6.89 0.35 2.9e-11 Colorectal cancer; CRC cis rs10905065 0.930 rs7909988 chr10:5736388 A/T cg11519256 chr10:5708881 ASB13 0.46 6.63 0.34 1.38e-10 Menopause (age at onset); CRC trans rs7615952 0.546 rs112919177 chr3:125346070 G/A cg07211511 chr3:129823064 LOC729375 -0.62 -7.25 -0.37 3.03e-12 Blood pressure (smoking interaction); CRC cis rs780096 0.506 rs8395 chr2:27715207 T/A cg12000995 chr2:27665139 KRTCAP3 -0.3 -6.11 -0.32 2.81e-9 Total body bone mineral density; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg17176195 chr11:71639533 LOC100133315;RNF121 0.5 6.42 0.33 4.84e-10 Thyroid stimulating hormone; CRC cis rs9534288 0.797 rs7998854 chr13:46592174 C/A cg15192986 chr13:46630673 CPB2 -0.66 -9.67 -0.47 1.23e-19 Blood protein levels; CRC cis rs7202877 0.656 rs4888394 chr16:75413709 T/C cg03315344 chr16:75512273 CHST6 0.49 5.65 0.3 3.51e-8 Type 2 diabetes;Type 1 diabetes; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg25706373 chr1:206858537 MAPKAPK2 0.45 6.27 0.33 1.13e-9 Anxiety disorder; CRC cis rs41005 1.000 rs41005 chr2:8111231 A/G cg03155496 chr2:8117019 LOC339788 -0.39 -7.04 -0.36 1.15e-11 Response to anti-TNF therapy in rheumatoid arthritis; CRC cis rs6540556 0.723 rs6752 chr1:209908100 G/A cg05527609 chr1:210001259 C1orf107 -0.57 -6.29 -0.33 1.01e-9 Red blood cell count; CRC cis rs76878669 0.561 rs6591217 chr11:66174653 G/A cg24851651 chr11:66362959 CCS 0.38 6.41 0.33 5.04e-10 Educational attainment (years of education); CRC cis rs10504229 0.906 rs73607869 chr8:58172665 G/T cg02290350 chr8:58132656 NA -0.42 -5.96 -0.31 6.62e-9 Developmental language disorder (linguistic errors); CRC cis rs2204008 0.744 rs67889662 chr12:38327042 T/A cg13010199 chr12:38710504 ALG10B 0.44 5.64 0.3 3.7e-8 Bladder cancer; CRC cis rs7493 0.901 rs2237586 chr7:95051052 G/T cg01874867 chr7:94954059 PON1 -0.52 -6.46 -0.34 3.79e-10 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs7666738 0.724 rs28451676 chr4:98966990 C/T cg17366294 chr4:99064904 C4orf37 0.43 7.36 0.38 1.49e-12 Colonoscopy-negative controls vs population controls; CRC cis rs4665809 0.938 rs35844686 chr2:26304949 A/G cg27170947 chr2:26402098 FAM59B 0.51 6.11 0.32 2.81e-9 Gut microbiome composition (summer); CRC cis rs17270561 0.636 rs9393671 chr6:25789189 G/C cg16482183 chr6:26056742 HIST1H1C -0.6 -8.12 -0.41 9.28e-15 Iron status biomarkers; CRC cis rs8060686 0.545 rs17688076 chr16:68286427 C/A cg26727032 chr16:67993705 SLC12A4 -0.59 -6.41 -0.33 4.93e-10 HDL cholesterol;Metabolic syndrome; CRC cis rs2839186 0.721 rs13051200 chr21:47701693 A/T cg09417038 chr21:47716443 C21orf57 -0.41 -6.8 -0.35 4.94e-11 Testicular germ cell tumor; CRC cis rs7264396 0.635 rs6088971 chr20:34535373 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.64 -10.32 -0.49 8.03e-22 Total cholesterol levels; CRC cis rs853679 0.517 rs1904840 chr6:28108232 C/T cg12963246 chr6:28129442 ZNF389 0.49 5.7 0.3 2.71e-8 Depression; CRC cis rs1552244 0.554 rs17050705 chr3:10046398 G/C cg02579736 chr3:10068473 FANCD2;CIDECP 0.66 9.24 0.45 3.11e-18 Alzheimer's disease; CRC cis rs7591163 1.000 rs1039665 chr2:228717392 A/G cg21577049 chr2:228736449 WDR69 -0.47 -6.2 -0.32 1.71e-9 Blood pressure; CRC cis rs736408 0.562 rs13071584 chr3:52804487 T/C cg18099408 chr3:52552593 STAB1 -0.45 -7.54 -0.38 4.52e-13 Bipolar disorder; CRC cis rs4474465 0.850 rs4590904 chr11:78263847 C/T cg27205649 chr11:78285834 NARS2 0.5 6.41 0.33 5.19e-10 Alzheimer's disease (survival time); CRC cis rs28386778 0.897 rs2727323 chr17:61921999 G/T cg06873352 chr17:61820015 STRADA 0.76 14.24 0.62 3.62e-36 Prudent dietary pattern; CRC cis rs12618769 0.652 rs17506535 chr2:99222834 G/C cg18455616 chr2:99124870 INPP4A 0.35 5.82 0.31 1.41e-8 Bipolar disorder; CRC cis rs6815814 0.950 rs5743595 chr4:38802644 A/G cg06935464 chr4:38784597 TLR10 0.58 5.84 0.31 1.22e-8 Breast cancer; CRC cis rs875971 0.540 rs4717275 chr7:65265180 C/T cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.49 -7.21 -0.37 3.93e-12 Aortic root size; CRC cis rs7640424 0.784 rs68044584 chr3:107845395 A/G cg09227934 chr3:107805635 CD47 -0.45 -6.68 -0.35 1.01e-10 Body mass index; CRC cis rs7552404 0.960 rs12085123 chr1:76149749 G/A cg03433033 chr1:76189801 ACADM 0.82 11.35 0.53 2.04e-25 Blood metabolite levels;Acylcarnitine levels; CRC cis rs6429082 0.818 rs291386 chr1:235647050 C/T cg26050004 chr1:235667680 B3GALNT2 0.59 8.18 0.41 6.07e-15 Adiposity; CRC trans rs1005277 0.579 rs2474608 chr10:38457109 C/T cg17830980 chr10:43048298 ZNF37B -0.59 -9.89 -0.48 2.27e-20 Extrinsic epigenetic age acceleration; CRC cis rs1577917 0.771 rs7762321 chr6:86412146 A/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A 0.59 8.39 0.42 1.49e-15 Response to antipsychotic treatment; CRC cis rs9903692 0.954 rs34750858 chr17:46132937 T/A cg21215337 chr17:46176117 CBX1 0.43 7.83 0.4 6.68e-14 Pulse pressure; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg26924209 chr1:193074740 GLRX2 0.45 6.66 0.34 1.15e-10 Intelligence (multi-trait analysis); CRC cis rs7849530 0.538 rs11788610 chr9:94969508 A/G cg21205276 chr9:95056231 IARS;SNORA84 0.58 6.02 0.32 4.56e-9 Left inferior lateral ventricle volume (Cerebrospinal fluid biomarker status interaction); CRC cis rs9296092 0.538 rs9469486 chr6:33516849 G/A cg13560919 chr6:33536144 NA -0.42 -5.94 -0.31 7.09e-9 Age at smoking initiation in chronic obstructive pulmonary disease; CRC cis rs1593 0.734 rs4253407 chr4:187193308 A/T cg09526685 chr4:187126073 CYP4V2 0.38 5.61 0.3 4.28e-8 Activated partial thromboplastin time; CRC cis rs8062405 0.755 rs4788074 chr16:28593597 A/G cg05139728 chr16:28306816 SBK1 0.37 6.01 0.31 4.85e-9 Cognitive ability (multi-trait analysis);Cognitive ability; CRC cis rs763014 0.932 rs35067229 chr16:649638 T/C cg07343612 chr16:622815 PIGQ -0.82 -14.24 -0.62 3.66e-36 Height; CRC cis rs2243480 0.831 rs7806717 chr7:65393174 A/G cg12463550 chr7:65579703 CRCP -0.63 -6.04 -0.32 4.17e-9 Diabetic kidney disease; CRC cis rs17376456 0.877 rs9314092 chr5:93326362 A/G cg25358565 chr5:93447407 FAM172A 0.97 10.07 0.49 5.84e-21 Diabetic retinopathy; CRC cis rs4713118 0.513 rs156734 chr6:28007357 A/C cg12273811 chr6:28175739 NA 0.57 8.37 0.42 1.73e-15 Parkinson's disease; CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg15693898 chr3:183602556 PARL 0.41 6.47 0.34 3.53e-10 Obesity-related traits; CRC cis rs6503863 1 rs6503863 chr17:56517034 G/A cg12560992 chr17:57184187 TRIM37 0.58 8.8 0.44 7.9e-17 Intelligence (multi-trait analysis); CRC cis rs919433 0.648 rs3097384 chr2:198278834 T/A cg10820045 chr2:198174542 NA 0.38 6.38 0.33 6.09e-10 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC cis rs7591163 0.959 rs10933217 chr2:228716226 T/C cg21577049 chr2:228736449 WDR69 -0.47 -6.28 -0.33 1.09e-9 Blood pressure; CRC cis rs7811142 1.000 rs4472444 chr7:100070758 T/C cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.16 17.21 0.69 8.33e-48 Platelet count; CRC cis rs1799949 1.000 rs2271573 chr17:41327621 A/G cg05368731 chr17:41323189 NBR1 0.65 9.51 0.46 4.26e-19 Menopause (age at onset); CRC trans rs11098499 1.000 rs7659194 chr4:120207147 T/G cg25214090 chr10:38739885 LOC399744 0.52 7.88 0.4 4.94e-14 Corneal astigmatism; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg24858591 chr3:44803638 KIAA1143;KIF15 0.46 6.77 0.35 5.89e-11 Response to antipsychotic treatment; CRC cis rs1891275 0.509 rs76313529 chr10:93443076 T/C cg07889827 chr10:93443413 NA -0.37 -6.25 -0.33 1.25e-9 Intelligence (multi-trait analysis); CRC cis rs9916302 0.904 rs4357971 chr17:37717280 C/T cg03013999 chr17:37608204 MED1 0.47 7.31 0.37 2.05e-12 Glomerular filtration rate (creatinine); CRC cis rs2239547 0.603 rs34230854 chr3:53078590 C/A cg05573699 chr3:52720067 GNL3;PBRM1 -0.46 -5.84 -0.31 1.23e-8 Schizophrenia; CRC cis rs5769765 0.862 rs9616381 chr22:50312382 G/A cg02269571 chr22:50332266 NA -0.61 -7.92 -0.4 3.64e-14 Schizophrenia; CRC cis rs7945705 0.935 rs11042103 chr11:8888700 C/T cg00186954 chr11:8933980 ST5;C11orf17 0.46 7.16 0.37 5.33e-12 Hemoglobin concentration; CRC trans rs2727020 0.658 rs10839278 chr11:49450847 G/C cg21153622 chr11:89784906 NA -0.37 -6.05 -0.32 3.95e-9 Coronary artery disease; CRC cis rs561341 1.000 rs506766 chr17:30289659 T/C cg23018236 chr17:30244563 NA -0.66 -7.59 -0.39 3.33e-13 Hip circumference adjusted for BMI; CRC cis rs875971 0.862 rs1612452 chr7:65573896 T/A cg00343986 chr7:65444356 GUSB -0.4 -5.78 -0.3 1.71e-8 Aortic root size; CRC cis rs35146811 0.586 rs6964754 chr7:99589404 G/A cg13334819 chr7:99746414 C7orf59 -0.44 -6.0 -0.31 5.32e-9 Coronary artery disease; CRC cis rs8072100 0.713 rs11079776 chr17:45546893 C/T cg08085267 chr17:45401833 C17orf57 -0.58 -8.93 -0.44 2.98e-17 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs1348850 0.668 rs12618542 chr2:178494520 A/G cg22681709 chr2:178499509 PDE11A -0.4 -6.48 -0.34 3.43e-10 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs6500602 0.563 rs917305 chr16:4440593 C/T cg14951292 chr16:4525986 HMOX2;NMRAL1 0.58 6.94 0.36 2.12e-11 Schizophrenia; CRC cis rs9868809 0.772 rs9811318 chr3:48702606 A/G cg00383909 chr3:49044727 WDR6 0.64 6.76 0.35 6.37e-11 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; CRC cis rs6842047 0.901 rs2102575 chr4:187131504 G/A cg09526685 chr4:187126073 CYP4V2 0.48 6.34 0.33 7.73e-10 Blood protein levels; CRC cis rs1448094 0.512 rs7133591 chr12:86239752 G/C cg02569458 chr12:86230093 RASSF9 0.43 7.34 0.38 1.68e-12 Major depressive disorder; CRC cis rs10193935 0.901 rs10175378 chr2:42456267 A/C cg27598129 chr2:42591480 NA -0.73 -8.2 -0.41 5.5e-15 Colonoscopy-negative controls vs population controls; CRC cis rs11168351 0.864 rs10875743 chr12:48498413 C/T cg00601486 chr12:48723148 H1FNT -0.35 -6.71 -0.35 8.48e-11 Bipolar disorder and schizophrenia; CRC cis rs10751667 0.666 rs7395321 chr11:940280 C/T cg23136738 chr11:925521 AP2A2 -0.42 -6.98 -0.36 1.65e-11 Alzheimer's disease (late onset); CRC cis rs9942416 0.660 rs17649055 chr5:74984269 C/T cg19683494 chr5:74908142 NA 0.51 6.47 0.34 3.65e-10 Age-related disease endophenotypes; CRC cis rs2172802 0.629 rs62304005 chr4:62494219 C/T cg04118610 chr4:62707027 LPHN3 0.38 5.64 0.3 3.6e-8 Partial epilepsies; CRC trans rs2243480 1.000 rs313798 chr7:65493031 A/G cg10756647 chr7:56101905 PSPH 0.77 7.94 0.4 3.29e-14 Diabetic kidney disease; CRC cis rs1448094 0.935 rs11117120 chr12:86336447 G/A cg02569458 chr12:86230093 RASSF9 0.38 6.57 0.34 1.99e-10 Major depressive disorder; CRC cis rs951366 0.789 rs1772148 chr1:205704580 A/T cg07157834 chr1:205819609 PM20D1 0.76 11.48 0.53 6.93e-26 Menarche (age at onset); CRC cis rs4862750 0.832 rs6836426 chr4:187897837 T/G cg10295955 chr4:187884368 NA -1.03 -25.55 -0.82 4.1e-80 Lobe attachment (rater-scored or self-reported); CRC cis rs11711311 1.000 rs9811353 chr3:113483979 G/A cg15478005 chr3:113465772 ATP6V1A;NAA50 0.45 6.3 0.33 9.55e-10 IgG glycosylation; CRC cis rs875971 1.000 rs11971949 chr7:65626014 A/G cg00343986 chr7:65444356 GUSB -0.45 -6.59 -0.34 1.75e-10 Aortic root size; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg14049615 chr4:87928107 AFF1 -0.42 -6.23 -0.32 1.4e-9 Myopia (pathological); CRC cis rs1881797 1.000 rs12071797 chr1:247686871 A/G cg05639522 chr1:247681581 NA 0.46 6.98 0.36 1.68e-11 Acute lymphoblastic leukemia (childhood); CRC cis rs3806843 0.900 rs116210441 chr5:140128649 T/A cg19875535 chr5:140030758 IK -0.53 -8.36 -0.42 1.77e-15 Depressive symptoms (multi-trait analysis); CRC cis rs1448094 0.813 rs6539942 chr12:86452969 T/C cg18827107 chr12:86230957 RASSF9 0.36 5.71 0.3 2.49e-8 Major depressive disorder; CRC cis rs262150 1.000 rs262150 chr7:158777934 G/A cg10570241 chr7:158785291 NA 0.48 8.25 0.41 3.73e-15 Facial morphology (factor 20); CRC cis rs1150668 0.768 rs1233713 chr6:28198281 A/G cg10876282 chr6:28092338 ZSCAN16 0.4 5.83 0.31 1.32e-8 Pubertal anthropometrics; CRC cis rs1577917 1.000 rs1857965 chr6:86630776 T/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.52 -6.78 -0.35 5.63e-11 Response to antipsychotic treatment; CRC cis rs7827545 1.000 rs1372660 chr8:135566788 C/G cg17885191 chr8:135476712 NA 0.52 7.03 0.36 1.18e-11 Hypertension (SNP x SNP interaction); CRC cis rs1008375 1.000 rs1558378 chr4:17650351 T/C cg04450456 chr4:17643702 FAM184B 0.37 5.88 0.31 9.91e-9 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs12540874 0.728 rs3807563 chr7:50566390 C/T cg18232548 chr7:50535776 DDC -0.52 -7.71 -0.39 1.49e-13 Systemic sclerosis; CRC cis rs11711311 1.000 rs9855613 chr3:113448455 G/A cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.51 -7.03 -0.36 1.23e-11 IgG glycosylation; CRC cis rs2832191 0.935 rs11910475 chr21:30519702 T/C cg08807101 chr21:30365312 RNF160 -0.61 -9.65 -0.47 1.46e-19 Dental caries; CRC cis rs2243480 1.000 rs6460274 chr7:65628484 T/A cg12463550 chr7:65579703 CRCP -0.71 -6.52 -0.34 2.65e-10 Diabetic kidney disease; CRC cis rs727563 0.635 rs713988 chr22:42159072 A/G cg06481639 chr22:41940642 POLR3H 0.56 6.16 0.32 2.09e-9 Crohn's disease;Inflammatory bowel disease; CRC cis rs9926296 0.548 rs6500439 chr16:89808275 A/C cg27121462 chr16:89883253 FANCA 0.57 8.9 0.44 3.95e-17 Vitiligo; CRC cis rs738322 0.967 rs4385 chr22:38573229 T/C cg25457927 chr22:38595422 NA -0.35 -7.45 -0.38 8.28e-13 Cutaneous nevi; CRC cis rs13202913 0.581 rs12662412 chr6:151824309 T/A cg10883421 chr6:151773342 RMND1;C6orf211 0.59 6.66 0.34 1.18e-10 Epstein-Barr virus copy number in lymphoblastoid cell lines; CRC cis rs651907 0.535 rs13084113 chr3:101534039 C/G cg11279151 chr3:101281821 RG9MTD1 -0.51 -6.66 -0.34 1.14e-10 Colorectal cancer; CRC cis rs1552244 0.554 rs6762594 chr3:9995516 G/A cg13047869 chr3:10149882 C3orf24 0.36 5.7 0.3 2.73e-8 Alzheimer's disease; CRC cis rs7927771 1.000 rs2290850 chr11:47807774 T/C cg05585544 chr11:47624801 NA -0.62 -10.82 -0.51 1.47e-23 Subjective well-being; CRC cis rs9611565 0.649 rs2413659 chr22:42164862 A/G cg03806693 chr22:41940476 POLR3H 0.66 9.19 0.45 4.5e-18 Vitiligo; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg27657473 chr17:4901092 INCA1;KIF1C -0.41 -6.26 -0.33 1.19e-9 Myopia (pathological); CRC cis rs7412746 0.611 rs16827671 chr1:150738759 T/C cg10589385 chr1:150898437 SETDB1 0.29 6.0 0.31 5.3e-9 Melanoma; CRC cis rs9926296 0.528 rs4785721 chr16:89839997 G/A cg03388025 chr16:89894329 SPIRE2 0.42 8.28 0.42 3.08e-15 Vitiligo; CRC cis rs9660180 0.620 rs3817856 chr1:1663831 C/T cg13866156 chr1:1669148 SLC35E2 0.71 11.12 0.52 1.32e-24 Body mass index; CRC cis rs10865397 0.506 rs6546810 chr2:73389716 A/G cg01422370 chr2:73384389 NA 0.35 5.73 0.3 2.3e-8 Intelligence (multi-trait analysis); CRC cis rs765787 0.530 rs4270107 chr15:45535350 A/G cg24006582 chr15:45444508 DUOX1 -0.57 -8.79 -0.44 8.5e-17 Uric acid levels; CRC cis rs1552244 1.000 rs12374115 chr3:10134766 A/G cg13047869 chr3:10149882 C3orf24 -0.51 -7.07 -0.36 9.23e-12 Alzheimer's disease; CRC cis rs9309473 0.898 rs10197755 chr2:73797623 T/A cg20560298 chr2:73613845 ALMS1 -0.47 -5.81 -0.31 1.47e-8 Metabolite levels; CRC cis rs4700695 0.841 rs417152 chr5:65316205 G/A cg21114390 chr5:65439923 SFRS12 0.57 6.99 0.36 1.58e-11 Facial morphology (factor 19); CRC cis rs11212617 0.967 rs228588 chr11:108113331 C/G cg01991180 chr11:108092276 ATM;NPAT 0.42 6.13 0.32 2.52e-9 Response to metformin in type 2 diabetes (glycemic); CRC cis rs2115630 1.000 rs1030863 chr15:85282635 C/T cg09876464 chr15:85330779 ZNF592 0.44 7.31 0.37 2.09e-12 P wave terminal force; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg05056390 chr11:124824120 CCDC15 0.45 6.27 0.33 1.15e-9 Response to antipsychotic treatment; CRC cis rs2404602 0.583 rs35707798 chr15:76565026 G/C cg26408565 chr15:76604113 ETFA -0.38 -6.03 -0.32 4.49e-9 Blood metabolite levels; CRC cis rs7647973 1.000 rs9842132 chr3:49427933 G/A cg20833759 chr3:49053208 WDR6;DALRD3 -0.55 -8.2 -0.41 5.38e-15 Menarche (age at onset); CRC cis rs4409675 0.576 rs6564 chr1:28212975 A/G cg11176159 chr1:28213800 NA -0.29 -5.75 -0.3 2.08e-8 Corneal astigmatism; CRC cis rs6951245 1.000 rs1997243 chr7:1083777 A/G cg04025307 chr7:1156635 C7orf50 0.64 6.76 0.35 6.29e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs2760061 0.819 rs708115 chr1:228198046 C/T cg01200585 chr1:228362443 C1orf69 0.39 5.73 0.3 2.22e-8 Diastolic blood pressure; CRC cis rs763014 1.000 rs7205409 chr16:642610 A/G cg09263875 chr16:632152 PIGQ 0.66 10.22 0.49 1.76e-21 Height; CRC cis rs365302 1.000 rs432598 chr6:159645755 C/G cg14500486 chr6:159655392 FNDC1 0.43 6.59 0.34 1.76e-10 Coronary heart disease; CRC cis rs919433 0.963 rs1896857 chr2:198164530 A/G cg20885578 chr2:198174922 NA -0.38 -6.33 -0.33 8.07e-10 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC cis rs10540 1.000 rs61876332 chr11:487101 C/T cg21784768 chr11:537496 LRRC56 -0.66 -6.13 -0.32 2.48e-9 Body mass index; CRC cis rs10489202 0.657 rs201541 chr1:167992344 T/A cg24449463 chr1:168025552 DCAF6 -0.61 -9.23 -0.45 3.38e-18 Schizophrenia; CRC cis rs2559856 1.000 rs10778139 chr12:102083202 C/T cg12924262 chr12:102091054 CHPT1 -0.57 -8.59 -0.43 3.55e-16 Blood protein levels; CRC cis rs13392177 0.660 rs62185964 chr2:219073745 A/G cg04731861 chr2:219085781 ARPC2 0.32 6.5 0.34 2.93e-10 Pyoderma gangrenosum in inflammatory bowel disease; CRC cis rs7932354 0.528 rs4319472 chr11:47109514 G/C cg03339077 chr11:47165057 C11orf49 -0.45 -6.19 -0.32 1.77e-9 Bone mineral density (hip);Bone mineral density; CRC cis rs479844 1.000 rs479844 chr11:65551957 A/G cg08755490 chr11:65554678 OVOL1 0.49 7.19 0.37 4.33e-12 Allergic disease (asthma, hay fever or eczema);Atopic march;Atopic dermatitis; CRC cis rs2842992 0.724 rs2273823 chr6:160211485 T/C cg19482086 chr6:160211437 TCP1;MRPL18 0.84 13.56 0.6 1.38e-33 Age-related macular degeneration (geographic atrophy); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg03044510 chr21:27107978 ATP5J;GABPA 0.41 6.54 0.34 2.31e-10 Liver disease severity in Alagille syndrome; CRC cis rs6951245 0.935 rs61910751 chr7:1097895 A/G cg24642844 chr7:1081250 C7orf50 -0.76 -9.16 -0.45 5.78e-18 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs713587 0.626 rs62140636 chr2:25233811 T/C cg22495460 chr2:25135724 ADCY3 0.65 10.99 0.52 3.73e-24 Body mass index in non-asthmatics; CRC cis rs1401999 0.807 rs9869029 chr3:183735286 C/G cg20387954 chr3:183756860 HTR3D 0.47 8.04 0.41 1.6e-14 Anterior chamber depth; CRC trans rs800082 0.690 rs2118001 chr3:144336609 T/C cg24215973 chr2:240111563 HDAC4 -0.61 -9.79 -0.47 5.03e-20 Smoking behavior; CRC cis rs79387448 0.701 rs3752659 chr2:103001598 A/G cg09003973 chr2:102972529 NA 0.87 9.52 0.46 3.87e-19 Gut microbiota (bacterial taxa); CRC cis rs939658 0.805 rs35602654 chr15:79417527 T/A cg17916960 chr15:79447300 NA -0.45 -7.3 -0.37 2.2e-12 Refractive error; CRC cis rs34172651 0.517 rs8059004 chr16:24837905 G/A cg06505273 chr16:24850292 NA 0.53 6.93 0.36 2.2e-11 Intelligence (multi-trait analysis); CRC cis rs139156536 1 rs139156536 chr17:38164432 TTTTA/T cg17467752 chr17:38218738 THRA 0.58 9.14 0.45 6.66e-18 Lymphocyte percentage of white cells; CRC cis rs13108904 0.840 rs13106092 chr4:1257290 T/A cg00684032 chr4:1343700 KIAA1530 0.47 6.95 0.36 1.97e-11 Obesity-related traits; CRC cis rs9549367 0.789 rs2287250 chr13:113889474 C/T cg24300038 chr13:113819356 PROZ 0.44 6.01 0.31 4.96e-9 Platelet distribution width; CRC cis rs968567 1.000 rs968567 chr11:61595564 C/T cg06781209 chr11:61594997 FADS2 -0.71 -8.37 -0.42 1.64e-15 Blood metabolite levels;Rheumatoid arthritis;Vitiligo;Glycerophospholipid levels; CRC cis rs28386778 0.897 rs2727320 chr17:61865325 T/C cg07362569 chr17:61921086 SMARCD2 0.37 5.7 0.3 2.7e-8 Prudent dietary pattern; CRC cis rs3772130 0.564 rs28620947 chr3:121585631 G/A cg20356878 chr3:121714668 ILDR1 0.56 10.91 0.52 7.62e-24 Cognitive performance; CRC cis rs13394619 0.744 rs10929759 chr2:11722012 C/G cg07314298 chr2:11723111 GREB1 0.53 9.26 0.45 2.66e-18 Endometriosis; CRC cis rs9467711 0.559 rs6920256 chr6:26537801 G/A cg12315302 chr6:26189340 HIST1H4D 0.71 5.76 0.3 1.93e-8 Autism spectrum disorder or schizophrenia; CRC cis rs3806843 0.966 rs2563261 chr5:140137713 G/T cg19875535 chr5:140030758 IK -0.61 -10.01 -0.48 9.04e-21 Depressive symptoms (multi-trait analysis); CRC cis rs7523050 0.730 rs7519107 chr1:109399367 A/C cg08274380 chr1:109419600 GPSM2 0.83 6.35 0.33 7.02e-10 Fat distribution (HIV); CRC cis rs1552172 0.887 rs718942 chr1:145662853 T/A cg11743829 chr1:145714124 CD160 -0.41 -6.16 -0.32 2.16e-9 Breast cancer; CRC cis rs9527 0.640 rs7089061 chr10:104723015 C/A cg15744005 chr10:104629667 AS3MT -0.31 -6.23 -0.32 1.41e-9 Arsenic metabolism; CRC cis rs727505 1.000 rs10228201 chr7:124449895 A/G cg23710748 chr7:124431027 NA -0.81 -14.48 -0.62 4.19e-37 Lewy body disease; CRC cis rs28386778 0.897 rs2584627 chr17:61901439 T/C cg06601766 chr17:61851465 DDX42;CCDC47 0.45 6.14 0.32 2.33e-9 Prudent dietary pattern; CRC cis rs17270561 0.609 rs7746609 chr6:25727996 C/T cg16482183 chr6:26056742 HIST1H1C -0.64 -8.51 -0.42 6.05e-16 Iron status biomarkers; CRC cis rs17767392 0.834 rs56362777 chr14:71735418 G/C cg13720639 chr14:72061746 SIPA1L1 -0.53 -6.42 -0.33 4.67e-10 Mitral valve prolapse; CRC cis rs853679 0.517 rs4713144 chr6:28106790 C/G cg12273811 chr6:28175739 NA 0.73 9.36 0.46 1.34e-18 Depression; CRC trans rs3942852 0.568 rs10769313 chr11:48097466 A/G cg03929089 chr4:120376271 NA -0.6 -8.23 -0.41 4.37e-15 Acute lymphoblastic leukemia (childhood); CRC cis rs9916302 0.752 rs676882 chr17:37433424 A/T cg07936489 chr17:37558343 FBXL20 0.81 10.04 0.48 7.17e-21 Glomerular filtration rate (creatinine); CRC cis rs10489202 0.632 rs275143 chr1:168056724 A/G cg24449463 chr1:168025552 DCAF6 -0.62 -9.3 -0.46 1.96e-18 Schizophrenia; CRC cis rs6701037 0.681 rs1057246 chr1:175127534 C/G cg00321850 chr1:175162397 KIAA0040 0.4 6.7 0.35 9e-11 Alcohol dependence; CRC cis rs10540 1.000 rs12788729 chr11:502371 G/A cg03352830 chr11:487213 PTDSS2 0.67 7.71 0.39 1.48e-13 Body mass index; CRC cis rs7216064 1.000 rs62084249 chr17:65874998 A/G cg12091567 chr17:66097778 LOC651250 -0.67 -7.74 -0.39 1.24e-13 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CRC cis rs12477438 0.520 rs2964969 chr2:99782811 G/A cg26064155 chr2:99771622 LIPT1;TSGA10 0.87 15.96 0.66 7.31e-43 Chronic sinus infection; CRC cis rs10911251 0.509 rs4652780 chr1:183105923 G/C ch.1.3577855R chr1:183094577 LAMC1 0.82 13.99 0.61 3.3e-35 Colorectal cancer; CRC cis rs4713118 0.866 rs9468217 chr6:27726467 G/A cg02683197 chr6:28174875 NA 0.64 7.5 0.38 6.09e-13 Parkinson's disease; CRC cis rs9322193 0.886 rs17672976 chr6:150097343 T/A cg07701084 chr6:150067640 NUP43 0.47 6.61 0.34 1.51e-10 Lung cancer; CRC cis rs9467711 0.606 rs1977 chr6:26377546 A/G cg14345882 chr6:26364793 BTN3A2 0.66 5.75 0.3 2.03e-8 Autism spectrum disorder or schizophrenia; CRC cis rs155076 0.938 rs536209 chr13:21847714 C/T cg21970626 chr13:21893289 NA 0.45 5.91 0.31 8.39e-9 White matter hyperintensity burden; CRC cis rs1801251 0.778 rs778338 chr2:233740227 A/G cg25237894 chr2:233734115 C2orf82 -0.63 -10.99 -0.52 3.98e-24 Coronary artery disease; CRC trans rs17685 0.712 rs869805 chr7:75688596 C/T cg19862616 chr7:65841803 NCRNA00174 0.99 18.63 0.72 2.21e-53 Coffee consumption;Coffee consumption (cups per day); CRC cis rs6840360 0.642 rs7682770 chr4:152390413 A/C cg09659197 chr4:152720779 NA 0.34 6.64 0.34 1.27e-10 Intelligence (multi-trait analysis); CRC cis rs2072499 0.750 rs10159384 chr1:156160822 C/T cg25208724 chr1:156163844 SLC25A44 1.01 16.24 0.67 5.94e-44 Testicular germ cell tumor; CRC trans rs4263408 0.934 rs9683743 chr4:39703194 A/C cg03646922 chr17:4167316 ANKFY1 -0.4 -6.14 -0.32 2.41e-9 Plasma amyloid beta peptide concentrations (ABx-40); CRC cis rs2976388 0.573 rs1529865 chr8:143789171 C/T cg12516270 chr8:143859308 LYNX1 0.42 7.54 0.38 4.55e-13 Urinary tract infection frequency; CRC trans rs1814175 0.765 rs1722003 chr11:49895896 G/A cg11707556 chr5:10655725 ANKRD33B -0.44 -8.44 -0.42 1.03e-15 Height; CRC cis rs4319547 0.626 rs12423420 chr12:122938466 G/A cg05707623 chr12:122985044 ZCCHC8 -0.58 -7.61 -0.39 2.87e-13 Body mass index; CRC cis rs394563 0.901 rs448874 chr6:149796967 C/T cg16235748 chr6:149772707 ZC3H12D -0.36 -6.26 -0.33 1.22e-9 Dupuytren's disease; CRC trans rs7395662 0.927 rs117030714 chr11:48760511 C/T cg21153622 chr11:89784906 NA 0.46 7.39 0.38 1.26e-12 HDL cholesterol; CRC trans rs6545883 0.929 rs12617911 chr2:61740825 A/G cg11704114 chr12:21509398 SLCO1A2 -0.32 -6.07 -0.32 3.57e-9 Tuberculosis; CRC cis rs208515 0.525 rs12193560 chr6:66690457 A/T cg07460842 chr6:66804631 NA 0.95 12.01 0.55 8.27e-28 Exhaled nitric oxide levels; CRC cis rs951366 0.789 rs864783 chr1:205711974 T/C cg26354017 chr1:205819088 PM20D1 0.73 11.02 0.52 3e-24 Menarche (age at onset); CRC cis rs6952808 0.689 rs871924 chr7:2047845 A/G cg14004847 chr7:1930337 MAD1L1 -0.41 -5.6 -0.3 4.5e-8 Bipolar disorder and schizophrenia; CRC cis rs6951245 1.000 rs79443843 chr7:1075245 G/A cg22907277 chr7:1156413 C7orf50 0.72 7.53 0.38 4.91e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs6570726 0.935 rs432086 chr6:145841593 C/T cg23711669 chr6:146136114 FBXO30 -0.7 -12.42 -0.56 2.62e-29 Lobe attachment (rater-scored or self-reported); CRC cis rs709400 0.663 rs11624367 chr14:103892818 T/A cg12935359 chr14:103987150 CKB -0.52 -8.06 -0.41 1.43e-14 Body mass index; CRC cis rs875971 0.862 rs778702 chr7:65864835 G/A cg18876405 chr7:65276391 NA 0.51 8.6 0.43 3.29e-16 Aortic root size; CRC cis rs7917772 0.502 rs10748827 chr10:104368336 G/T cg04362960 chr10:104952993 NT5C2 -0.42 -5.9 -0.31 9.14e-9 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC cis rs8078723 1.000 rs4795416 chr17:38158133 C/T cg17344932 chr17:38183730 MED24;SNORD124 -0.45 -6.9 -0.36 2.73e-11 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); CRC cis rs7259376 0.875 rs9304996 chr19:22486535 A/G cg02657401 chr19:22469223 NA -0.36 -8.0 -0.4 2.14e-14 Menopause (age at onset); CRC cis rs9584850 0.834 rs7334078 chr13:99120484 C/T cg07423050 chr13:99094983 FARP1 -0.45 -6.46 -0.34 3.71e-10 Neuroticism; CRC cis rs950169 0.610 rs34529571 chr15:84691807 A/G cg11189052 chr15:85197271 WDR73 0.57 7.55 0.38 4.25e-13 Schizophrenia; CRC trans rs1814175 0.712 rs9665784 chr11:50030617 C/T cg03929089 chr4:120376271 NA -0.96 -19.27 -0.73 6.37e-56 Height; CRC cis rs4718428 0.705 rs3800817 chr7:66263550 T/A cg25985355 chr7:65971099 NA -0.35 -5.64 -0.3 3.7e-8 Corneal structure; CRC cis rs8180040 0.966 rs11719877 chr3:47425473 C/T cg10298567 chr3:47292165 KIF9 -0.35 -5.83 -0.31 1.33e-8 Colorectal cancer; CRC cis rs514406 0.830 rs533935 chr1:53308807 T/C cg27535305 chr1:53392650 SCP2 -0.37 -6.74 -0.35 6.97e-11 Monocyte count; CRC cis rs1218582 0.596 rs4845676 chr1:154827861 C/G cg09359103 chr1:154839909 KCNN3 -0.56 -8.43 -0.42 1.07e-15 Prostate cancer; CRC cis rs6424115 0.867 rs2501432 chr1:24201920 T/C cg15997130 chr1:24165203 NA 0.73 10.74 0.51 2.79e-23 Immature fraction of reticulocytes; CRC cis rs889312 0.521 rs12651942 chr5:56088484 C/T cg20203395 chr5:56204925 C5orf35 -0.41 -5.76 -0.3 1.94e-8 Breast cancer;Breast cancer (early onset); CRC cis rs6951245 0.572 rs60918895 chr7:1039036 C/T cg24642844 chr7:1081250 C7orf50 -0.75 -6.74 -0.35 7.12e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg22779477 chr10:127408223 C10orf137 0.37 6.18 0.32 1.89e-9 Liver disease severity in Alagille syndrome; CRC cis rs34172651 0.876 rs964782 chr16:24811740 T/C cg06028605 chr16:24865363 SLC5A11 0.44 7.95 0.4 2.93e-14 Intelligence (multi-trait analysis); CRC cis rs7945718 0.935 rs4757059 chr11:12812356 G/A cg25843174 chr11:12811716 TEAD1 -0.47 -8.77 -0.44 9.9900000000000006e-17 Educational attainment (years of education); CRC cis rs7927592 0.913 rs10896346 chr11:68352671 C/T cg01657329 chr11:68192670 LRP5 -0.47 -6.79 -0.35 5.16e-11 Total body bone mineral density; CRC cis rs62229266 0.804 rs2255858 chr21:37412752 T/C cg12218747 chr21:37451666 NA -0.43 -7.39 -0.38 1.25e-12 Mitral valve prolapse; CRC cis rs9303401 1.000 rs6503877 chr17:56841948 C/T cg12560992 chr17:57184187 TRIM37 0.44 5.84 0.31 1.24e-8 Cognitive test performance; CRC trans rs3733585 0.699 rs6449157 chr4:9960442 G/A cg26043149 chr18:55253948 FECH -0.48 -7.43 -0.38 9.29e-13 Cleft plate (environmental tobacco smoke interaction); CRC cis rs10464366 0.957 rs2392618 chr7:39108392 G/A cg15212455 chr7:39170539 POU6F2 0.45 5.69 0.3 2.82e-8 IgG glycosylation; CRC cis rs796364 0.951 rs72932280 chr2:200996851 G/C cg12253985 chr2:200820533 C2orf60;C2orf47 -0.52 -5.73 -0.3 2.25e-8 Schizophrenia; CRC cis rs9906695 1.000 rs17652000 chr17:32550104 C/A cg12698626 chr17:32581466 CCL2 0.41 5.63 0.3 3.81e-8 Monocyte percentage of white cells; CRC cis rs9372498 0.536 rs9489447 chr6:118900846 G/A cg15382696 chr6:118971807 C6orf204 0.62 8.0 0.4 2.17e-14 Diastolic blood pressure; CRC cis rs17713451 0.593 rs75885547 chr7:151279118 T/C cg18404559 chr7:151322523 PRKAG2 -0.54 -6.2 -0.32 1.66e-9 Interleukin-4 levels; CRC cis rs9388451 0.872 rs2008027 chr6:126052359 A/G cg10911889 chr6:126070802 HEY2 0.38 5.79 0.3 1.65e-8 Brugada syndrome; CRC cis rs12135062 1.000 rs12135062 chr1:3103312 A/C cg21609526 chr1:3105151 PRDM16 0.52 8.85 0.44 5.6e-17 Migraine; CRC cis rs7811142 1.000 rs6975729 chr7:100028187 C/T cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.17 17.44 0.69 1.04e-48 Platelet count; CRC cis rs1451375 1.000 rs10250513 chr7:50621488 T/G cg18232548 chr7:50535776 DDC 0.47 6.62 0.34 1.43e-10 Malaria; CRC cis rs367615 0.506 rs246102 chr5:108699695 C/G cg17395555 chr5:108820864 NA -0.35 -6.68 -0.35 9.97e-11 Colorectal cancer (SNP x SNP interaction); CRC cis rs651907 0.535 rs11707250 chr3:101509371 A/T cg03837452 chr3:101395095 ZBTB11;LOC100009676 -0.59 -7.8 -0.4 8.2e-14 Colorectal cancer; CRC cis rs910316 0.712 rs175037 chr14:75465038 T/C cg03030879 chr14:75389066 RPS6KL1 0.38 5.67 0.3 3.12e-8 Height; CRC cis rs6543140 0.927 rs917999 chr2:103067869 G/A cg09003973 chr2:102972529 NA 0.41 5.86 0.31 1.11e-8 Blood protein levels; CRC cis rs7621025 0.500 rs12629000 chr3:136643571 T/A cg15507776 chr3:136538369 TMEM22 0.43 6.73 0.35 7.76e-11 C-reactive protein levels or HDL-cholesterol levels (pleiotropy);Body mass index; CRC cis rs9814567 1.000 rs9814567 chr3:134218557 C/T cg06541857 chr3:134203789 ANAPC13;CEP63 0.4 5.88 0.31 9.98e-9 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs801193 0.569 rs2707847 chr7:66202871 C/G cg11764359 chr7:65958608 NA 0.59 8.85 0.44 5.43e-17 Aortic root size; CRC cis rs769267 1.000 rs2301669 chr19:19453560 C/A cg01262667 chr19:19385393 TM6SF2 -0.37 -6.26 -0.33 1.17e-9 Tonsillectomy; CRC cis rs12760731 0.720 rs2175254 chr1:178319105 G/A cg00404053 chr1:178313656 RASAL2 1.12 11.43 0.53 1.04e-25 Obesity-related traits; CRC cis rs6540559 0.932 rs764093 chr1:209983331 A/G cg21951975 chr1:209979733 IRF6 0.44 6.79 0.35 5.28e-11 Cleft lip with or without cleft palate; CRC cis rs9926296 0.533 rs9938865 chr16:89867797 A/G cg03388025 chr16:89894329 SPIRE2 0.45 9.11 0.45 8.09e-18 Vitiligo; CRC cis rs4862750 0.872 rs10027252 chr4:187873462 T/G cg22105103 chr4:187893119 NA 0.61 10.54 0.5 1.38e-22 Lobe attachment (rater-scored or self-reported); CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg05165064 chr20:18037039 OVOL2 0.47 6.58 0.34 1.88e-10 Thyroid stimulating hormone; CRC cis rs921968 0.643 rs590771 chr2:219369851 C/T cg02176678 chr2:219576539 TTLL4 0.48 7.96 0.4 2.84e-14 Mean corpuscular hemoglobin concentration; CRC cis rs877282 0.945 rs71491311 chr10:791747 G/A cg06581033 chr10:766294 NA -0.51 -5.68 -0.3 2.97e-8 Uric acid levels; CRC cis rs1005277 0.579 rs2504143 chr10:38383706 C/T cg25427524 chr10:38739819 LOC399744 -0.77 -13.66 -0.6 5.87e-34 Extrinsic epigenetic age acceleration; CRC trans rs3780486 0.505 rs959749 chr9:33147858 T/C cg20290983 chr6:43655470 MRPS18A 0.95 17.24 0.69 6.44e-48 IgG glycosylation; CRC cis rs826838 1.000 rs1095575 chr12:39110284 C/G cg13010199 chr12:38710504 ALG10B -0.4 -5.89 -0.31 9.35e-9 Heart rate; CRC cis rs875971 0.862 rs1167399 chr7:65561877 G/A cg18876405 chr7:65276391 NA -0.51 -8.49 -0.42 6.96e-16 Aortic root size; CRC cis rs7258465 1.000 rs2303695 chr19:18562624 C/T cg01065977 chr19:18549689 ISYNA1 -0.41 -6.36 -0.33 6.75e-10 Breast cancer; CRC cis rs763121 0.853 rs9610993 chr22:39042818 C/A cg06022373 chr22:39101656 GTPBP1 0.78 12.39 0.56 3.54e-29 Menopause (age at onset); CRC trans rs10982213 0.830 rs2274163 chr9:117188714 C/T cg26322434 chr3:61237156 FHIT 0.42 6.1 0.32 3.04e-9 Interleukin-6 levels; CRC cis rs6665290 0.901 rs68087483 chr1:227202668 T/C cg10327440 chr1:227177885 CDC42BPA -1.02 -21.95 -0.77 2.14e-66 Myeloid white cell count; CRC trans rs916888 0.610 rs199536 chr17:44820425 T/C cg22968622 chr17:43663579 NA -0.86 -12.08 -0.55 4.59e-28 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs11719291 0.915 rs9834996 chr3:48754877 G/T cg07636037 chr3:49044803 WDR6 -0.71 -6.76 -0.35 6.38e-11 Cognitive function; CRC cis rs28386778 0.799 rs2727322 chr17:61921706 G/A cg11494091 chr17:61959527 GH2 0.6 10.33 0.49 7.77e-22 Prudent dietary pattern; CRC cis rs7113874 0.569 rs10769924 chr11:8623193 C/A cg02811074 chr11:8615871 STK33 0.36 6.15 0.32 2.22e-9 Body mass index in physically active individuals;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs6570726 0.846 rs409553 chr6:145886963 C/T cg13319975 chr6:146136371 FBXO30 -0.39 -5.86 -0.31 1.13e-8 Lobe attachment (rater-scored or self-reported); CRC cis rs9322193 0.962 rs4869966 chr6:150084850 A/G cg05861140 chr6:150128134 PCMT1 -0.44 -7.18 -0.37 4.53e-12 Lung cancer; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg17282769 chr12:11802362 ETV6 0.39 6.34 0.33 7.48e-10 Liver disease severity in Alagille syndrome; CRC cis rs10911251 0.528 rs4652779 chr1:183104552 G/A ch.1.3577855R chr1:183094577 LAMC1 0.88 15.33 0.65 2.18e-40 Colorectal cancer; CRC cis rs7618915 0.547 rs3774365 chr3:52642487 T/C cg08222913 chr3:52553049 STAB1 -0.34 -6.22 -0.32 1.54e-9 Bipolar disorder; CRC cis rs7552404 0.655 rs5745336 chr1:76273519 G/A cg10523679 chr1:76189770 ACADM 0.69 8.97 0.44 2.24e-17 Blood metabolite levels;Acylcarnitine levels; CRC cis rs3741151 0.892 rs7105681 chr11:73059341 G/A cg17517138 chr11:73019481 ARHGEF17 0.62 6.57 0.34 1.95e-10 GIP levels in response to oral glucose tolerance test (120 minutes); CRC cis rs1881797 1.000 rs1881797 chr1:247689532 A/G cg18198730 chr1:247681584 NA 0.61 11.06 0.52 2.14e-24 Acute lymphoblastic leukemia (childhood); CRC cis rs10504229 0.683 rs56211106 chr8:58113497 A/G cg05313129 chr8:58192883 C8orf71 -0.43 -6.0 -0.31 5.07e-9 Developmental language disorder (linguistic errors); CRC cis rs9291683 0.530 rs13115193 chr4:9982191 C/T cg11266682 chr4:10021025 SLC2A9 0.5 10.22 0.49 1.79e-21 Bone mineral density; CRC cis rs2658782 0.756 rs3019223 chr11:93084182 G/A cg15737290 chr11:93063684 CCDC67 0.53 7.52 0.38 5.24e-13 Pulmonary function decline; CRC cis rs9894429 0.646 rs6565612 chr17:79602820 C/T cg09655341 chr17:79618100 PDE6G 0.35 6.05 0.32 3.95e-9 Eye color traits; CRC cis rs6662572 0.737 rs75490316 chr1:46553785 G/A cg08644498 chr1:46502608 NA 0.43 6.6 0.34 1.64e-10 Blood protein levels; CRC cis rs1891275 0.515 rs1080496 chr10:93444262 C/T cg07889827 chr10:93443413 NA 0.4 6.9 0.36 2.67e-11 Intelligence (multi-trait analysis); CRC cis rs3806843 0.619 rs2569160 chr5:140028774 T/C cg19875535 chr5:140030758 IK -0.69 -11.69 -0.54 1.27e-26 Depressive symptoms (multi-trait analysis); CRC cis rs10782582 0.609 rs79835994 chr1:76287508 G/T cg03433033 chr1:76189801 ACADM -0.4 -5.62 -0.3 4.06e-8 Daytime sleep phenotypes; CRC cis rs6690583 0.697 rs2012369 chr1:85520845 T/C cg11262906 chr1:85462892 MCOLN2 -0.5 -6.96 -0.36 1.83e-11 Serum sulfate level; CRC cis rs10242455 0.702 rs115279860 chr7:98994492 C/T cg18809830 chr7:99032528 PTCD1 -1.28 -8.67 -0.43 1.94e-16 Blood metabolite levels; CRC cis rs72945132 0.638 rs627079 chr11:70165505 G/T cg14191688 chr11:70257035 CTTN 0.39 6.11 0.32 2.89e-9 Coronary artery disease; CRC cis rs9393777 0.513 rs7759969 chr6:26663096 T/A cg12292205 chr6:26970375 C6orf41 -0.62 -7.08 -0.36 8.59e-12 Intelligence (multi-trait analysis); CRC cis rs9522267 0.535 rs7323829 chr13:112232308 C/G cg10483660 chr13:112241077 NA -0.47 -8.67 -0.43 1.97e-16 Hepatitis; CRC cis rs4332037 0.539 rs56016347 chr7:2060126 C/T cg23422044 chr7:1970798 MAD1L1 -0.55 -6.59 -0.34 1.79e-10 Bipolar disorder; CRC cis rs875971 1.000 rs778699 chr7:65868290 G/A cg18876405 chr7:65276391 NA 0.52 9.04 0.45 1.37e-17 Aortic root size; CRC cis rs3804749 0.966 rs9823527 chr3:122842611 G/A cg26084141 chr3:122786895 PDIA5 0.22 6.15 0.32 2.23e-9 Plateletcrit;Mean platelet volume;Platelet count;Platelet distribution width; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg25973374 chr1:24194516 FUCA1 0.46 5.99 0.31 5.37e-9 Anxiety disorder; CRC trans rs9858542 0.903 rs11917431 chr3:49644012 C/T cg21582582 chr3:182698605 DCUN1D1 -0.52 -6.21 -0.32 1.59e-9 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs2836974 0.897 rs2026265 chr21:40595517 G/A cg17971929 chr21:40555470 PSMG1 0.82 11.69 0.54 1.24e-26 Cognitive function; CRC cis rs12928939 0.815 rs12448022 chr16:71724369 T/C cg08717414 chr16:71523259 ZNF19 -0.46 -5.87 -0.31 1.04e-8 Post bronchodilator FEV1; CRC trans rs12744310 0.887 rs34539673 chr1:41796817 G/A cg19175123 chr10:103411746 FBXW4 0.44 6.0 0.31 5.21e-9 Cognitive ability (multi-trait analysis);Intelligence;Cognitive ability; CRC cis rs7677751 0.806 rs73252942 chr4:55104604 T/C cg17187183 chr4:55093834 PDGFRA 0.51 7.49 0.38 6.2800000000000005e-13 Corneal astigmatism; CRC cis rs1401999 1.000 rs1402003 chr3:183642879 C/T cg01324343 chr3:183735012 ABCC5 0.79 14.33 0.62 1.65e-36 Anterior chamber depth; CRC cis rs826838 0.616 rs11182893 chr12:38627715 C/G cg13010199 chr12:38710504 ALG10B -0.42 -6.1 -0.32 2.99e-9 Heart rate; CRC cis rs7412746 0.634 rs7521592 chr1:150821691 A/C cg18016565 chr1:150552671 MCL1 0.46 6.3 0.33 9.72e-10 Melanoma; CRC trans rs875971 0.660 rs2191268 chr7:66110224 C/T cg05457514 chr20:44034744 DBNDD2;SYS1-DBNDD2 -0.42 -6.15 -0.32 2.19e-9 Aortic root size; CRC cis rs34172651 0.917 rs6497760 chr16:24806535 G/A cg06028605 chr16:24865363 SLC5A11 0.44 8.07 0.41 1.33e-14 Intelligence (multi-trait analysis); CRC cis rs7692995 1.000 rs73098848 chr4:17941027 G/C cg08925142 chr4:18023851 LCORL -0.52 -5.74 -0.3 2.14e-8 Height; CRC cis rs4974559 0.947 rs28540746 chr4:1352954 G/A cg02980000 chr4:1222292 CTBP1 0.72 8.07 0.41 1.3e-14 Systolic blood pressure; CRC trans rs561341 0.609 rs7214626 chr17:30190989 G/A cg20587970 chr11:113659929 NA 0.69 8.73 0.43 1.34e-16 Hip circumference adjusted for BMI; CRC cis rs13191362 0.507 rs2849527 chr6:163117932 G/T cg21926612 chr6:163149169 PACRG;PARK2 0.57 8.92 0.44 3.29e-17 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs7615952 0.641 rs4422257 chr3:125774363 A/G cg02772935 chr3:125709198 NA -0.49 -5.74 -0.3 2.11e-8 Blood pressure (smoking interaction); CRC cis rs16852403 0.517 rs12034044 chr1:178234409 G/T cg00404053 chr1:178313656 RASAL2 0.47 5.8 0.3 1.54e-8 Childhood ear infection; CRC cis rs561341 1.000 rs510264 chr17:30323414 A/G cg12193833 chr17:30244370 NA -0.76 -8.88 -0.44 4.43e-17 Hip circumference adjusted for BMI; CRC cis rs911555 0.755 rs6575988 chr14:103900827 G/T cg24130564 chr14:104152367 KLC1 0.42 5.86 0.31 1.14e-8 Intelligence (multi-trait analysis); CRC cis rs11679072 1.000 rs13410551 chr2:240447431 A/T cg03276489 chr2:240449683 NA -0.91 -9.19 -0.45 4.49e-18 Blood pressure (smoking interaction); CRC cis rs8062405 0.895 rs56186137 chr16:28825953 A/G cg16576597 chr16:28551801 NUPR1 0.49 7.13 0.37 6.53e-12 Cognitive ability (multi-trait analysis);Cognitive ability; CRC cis rs2180341 0.814 rs7768435 chr6:127737038 A/C cg27446573 chr6:127587934 RNF146 0.69 9.42 0.46 8.11e-19 Breast cancer; CRC cis rs4604732 0.588 rs4925551 chr1:247631724 T/A cg12758973 chr1:247694275 LOC148824;OR2C3 0.37 5.66 0.3 3.3e-8 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CRC cis rs231513 0.954 rs231516 chr17:41963205 G/A cg26893861 chr17:41843967 DUSP3 -0.65 -6.58 -0.34 1.85e-10 Cognitive function; CRC cis rs5753618 0.561 rs1858821 chr22:31676454 T/C cg07713946 chr22:31675144 LIMK2 -0.39 -5.63 -0.3 3.94e-8 Colorectal cancer; CRC cis rs4073416 0.542 rs1889731 chr14:65942711 C/G cg03016385 chr14:66212404 NA -0.43 -5.94 -0.31 7.44e-9 N-glycan levels; CRC cis rs7527798 0.592 rs11118278 chr1:207831357 C/G cg09232269 chr1:207846808 CR1L -0.5 -8.39 -0.42 1.43e-15 Erythrocyte sedimentation rate; CRC cis rs17155006 0.746 rs985152 chr7:107750357 G/A cg05962710 chr7:107745446 LAMB4 -0.41 -7.33 -0.37 1.77e-12 Pneumococcal bacteremia; CRC cis rs2832191 0.716 rs1984012 chr21:30392472 T/C cg24692254 chr21:30365293 RNF160 0.85 15.96 0.66 7.24e-43 Dental caries; CRC cis rs6598955 0.614 rs1134584 chr1:26608828 G/A cg04990556 chr1:26633338 UBXN11 -0.77 -12.98 -0.58 2.22e-31 Obesity-related traits; CRC cis rs17270561 0.609 rs1185976 chr6:25822363 A/G cg17691542 chr6:26056736 HIST1H1C -0.52 -7.53 -0.38 5.06e-13 Iron status biomarkers; CRC cis rs9649213 0.593 rs6970990 chr7:97925382 T/G cg00277769 chr7:97922759 BAIAP2L1 -0.61 -10.75 -0.51 2.71e-23 Prostate cancer (SNP x SNP interaction); CRC cis rs644799 0.509 rs580181 chr11:95643040 G/C cg03916912 chr11:95522834 CEP57;FAM76B 0.65 10.41 0.5 4.04e-22 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs9467160 1.000 rs6922631 chr6:24438734 G/A cg20631270 chr6:24437470 GPLD1 0.51 6.53 0.34 2.48e-10 Liver enzyme levels; CRC cis rs75920871 0.528 rs7930264 chr11:116870766 G/A cg01368799 chr11:117014884 PAFAH1B2 -0.4 -5.78 -0.3 1.71e-8 Subjective well-being; CRC cis rs8060686 0.623 rs56303487 chr16:68029739 C/T cg26727032 chr16:67993705 SLC12A4 -0.64 -8.68 -0.43 1.82e-16 HDL cholesterol;Metabolic syndrome; CRC cis rs9527 0.615 rs7073295 chr10:104672233 A/G cg15744005 chr10:104629667 AS3MT -0.3 -6.1 -0.32 3.02e-9 Arsenic metabolism; CRC cis rs2153535 0.540 rs9378557 chr6:8517381 T/C cg07606381 chr6:8435919 SLC35B3 0.66 10.74 0.51 2.78e-23 Motion sickness; CRC cis rs28386778 0.830 rs6504180 chr17:61813169 T/C cg22520471 chr17:61851767 DDX42;CCDC47 0.72 11.15 0.52 1.01e-24 Prudent dietary pattern; CRC cis rs6121246 0.529 rs750144 chr20:30179027 C/T cg13852791 chr20:30311386 BCL2L1 -0.63 -8.48 -0.42 7.47e-16 Mean corpuscular hemoglobin; CRC cis rs769267 0.930 rs2288852 chr19:19605348 T/C cg03709012 chr19:19516395 GATAD2A 0.73 11.35 0.53 1.98e-25 Tonsillectomy; CRC cis rs2120019 1.000 rs7167285 chr15:75368769 A/G cg17294928 chr15:75287854 SCAMP5 -0.73 -10.86 -0.51 1.1e-23 Blood trace element (Zn levels); CRC cis rs2252521 0.553 rs317705 chr7:29097148 T/C cg11728747 chr7:29037910 CPVL -0.52 -7.25 -0.37 2.96e-12 Cognitive performance; CRC trans rs2727020 1.000 rs2727020 chr11:49111407 C/G cg03929089 chr4:120376271 NA 0.63 8.55 0.43 4.55e-16 Coronary artery disease; CRC cis rs1348850 0.519 rs10201883 chr2:178471407 T/C cg27490568 chr2:178487706 NA 0.65 7.65 0.39 2.31e-13 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs7605827 0.930 rs2052435 chr2:15687306 A/T cg19274914 chr2:15703543 NA 0.37 5.62 0.3 4.13e-8 Educational attainment (years of education); CRC cis rs4713118 0.513 rs149941 chr6:28001033 T/C cg02683197 chr6:28174875 NA 0.61 8.44 0.42 9.89e-16 Parkinson's disease; CRC cis rs1129187 0.934 rs9471974 chr6:42918984 T/A cg26304593 chr6:42947056 PEX6 -0.42 -5.99 -0.31 5.39e-9 Alzheimer's disease in APOE e4+ carriers; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg08422181 chr19:4909468 UHRF1 0.44 6.26 0.33 1.17e-9 Anxiety disorder; CRC trans rs9388451 0.839 rs3757217 chr6:126069636 G/C cg05039488 chr6:79577232 IRAK1BP1 -0.58 -8.89 -0.44 4.05e-17 Brugada syndrome; CRC cis rs7659604 0.676 rs6855269 chr4:122697418 T/G cg19748678 chr4:122722346 EXOSC9 0.69 11.3 0.53 3.08e-25 Type 2 diabetes; CRC cis rs12024301 0.557 rs12038369 chr1:183608146 G/A cg11505048 chr1:183622726 RGL1;APOBEC4 0.77 6.73 0.35 7.45e-11 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs7580658 0.676 rs58475809 chr2:128002650 A/G cg09760422 chr2:128146352 NA -0.3 -5.79 -0.3 1.67e-8 Protein C levels; CRC cis rs910316 0.712 rs175015 chr14:75457075 A/C cg08847533 chr14:75593920 NEK9 -0.85 -14.56 -0.63 1.97e-37 Height; CRC cis rs951366 0.789 rs1775154 chr1:205696615 T/A cg17178900 chr1:205818956 PM20D1 0.67 9.85 0.48 3.24e-20 Menarche (age at onset); CRC cis rs875971 0.502 rs2946580 chr7:65531842 G/A cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.62 -7.93 -0.4 3.49e-14 Aortic root size; CRC trans rs6500957 0.920 rs17648524 chr16:7459683 C/G cg27018124 chr22:26879714 HPS4;SRRD 0.41 6.04 0.32 4.26e-9 Spherical equivalent (joint analysis main effects and education interaction); CRC cis rs754466 0.510 rs55893027 chr10:79588209 C/T cg17075019 chr10:79541650 NA -0.82 -14.36 -0.62 1.21e-36 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs9487051 0.676 rs7753705 chr6:109593302 A/C cg12927641 chr6:109611667 NA -0.36 -6.44 -0.33 4.15e-10 Reticulocyte fraction of red cells; CRC cis rs12220238 1.000 rs10824112 chr10:75969003 T/C cg19889307 chr10:75911429 ADK;AP3M1 0.54 5.61 0.3 4.26e-8 Soluble interleukin-2 receptor subunit alpha; CRC cis rs200986 1 rs200986 chr6:27824766 G/C cg23161317 chr6:28129485 ZNF389 0.43 6.12 0.32 2.66e-9 Autism spectrum disorder or schizophrenia; CRC cis rs1552244 0.572 rs3894323 chr3:10168967 G/A cg02579736 chr3:10068473 FANCD2;CIDECP 1.01 11.62 0.54 2.28e-26 Alzheimer's disease; CRC cis rs875971 0.895 rs1833495 chr7:65921595 T/C cg18876405 chr7:65276391 NA 0.52 8.85 0.44 5.32e-17 Aortic root size; CRC cis rs875971 0.505 rs2462573 chr7:65507392 C/T cg11764359 chr7:65958608 NA -0.53 -8.07 -0.41 1.29e-14 Aortic root size; CRC trans rs61931739 0.500 rs11053189 chr12:34433455 G/A cg26384229 chr12:38710491 ALG10B 0.66 8.81 0.44 7.3e-17 Morning vs. evening chronotype; CRC cis rs72781680 1.000 rs17712391 chr2:24245659 C/T cg08917208 chr2:24149416 ATAD2B 0.98 9.37 0.46 1.23e-18 Lymphocyte counts; CRC cis rs7927771 0.864 rs4752999 chr11:47428565 C/T cg05585544 chr11:47624801 NA -0.55 -9.76 -0.47 6.31e-20 Subjective well-being; CRC cis rs4862750 0.794 rs1030382 chr4:187903782 T/G cg07414643 chr4:187882934 NA 0.43 7.31 0.37 2.03e-12 Lobe attachment (rater-scored or self-reported); CRC cis rs6938 0.618 rs1133323 chr15:75212225 C/T cg18612461 chr15:75251733 NA 0.38 5.75 0.3 1.99e-8 Breast cancer; CRC cis rs116095464 0.558 rs12173015 chr5:269967 A/C cg22857025 chr5:266934 NA 1.02 14.59 0.63 1.52e-37 Breast cancer; CRC cis rs1552244 0.882 rs13063929 chr3:10010308 T/C cg00166722 chr3:10149974 C3orf24 0.63 8.25 0.41 3.98e-15 Alzheimer's disease; CRC cis rs7617480 0.648 rs6801211 chr3:48774420 C/G cg07636037 chr3:49044803 WDR6 0.85 11.43 0.53 1.05e-25 Subjective well-being (multi-trait analysis);Menarche (age at onset); CRC cis rs6121246 0.909 rs7272062 chr20:30259145 A/G cg13852791 chr20:30311386 BCL2L1 0.69 10.79 0.51 1.94e-23 Mean corpuscular hemoglobin; CRC trans rs951252 0.504 rs11734405 chr4:146081096 C/T cg21400344 chr1:25870172 LDLRAP1 0.48 6.54 0.34 2.31e-10 Hip circumference; CRC cis rs73195822 0.614 rs7975139 chr12:111221131 T/C cg12870014 chr12:110450643 ANKRD13A 0.68 7.68 0.39 1.87e-13 Itch intensity from mosquito bite; CRC cis rs798554 0.679 rs1639066 chr7:2892972 A/G cg19346786 chr7:2764209 NA -0.39 -6.64 -0.34 1.3e-10 Height; CRC trans rs2553218 0.690 rs8032415 chr15:54851945 A/G cg22373392 chr17:45973408 SP2 0.47 6.16 0.32 2.11e-9 Immune response to smallpox vaccine (IL-6); CRC cis rs9463078 0.753 rs1980265 chr6:44928868 C/A cg25276700 chr6:44698697 NA -0.28 -6.74 -0.35 6.95e-11 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; CRC cis rs75920871 0.512 rs6589583 chr11:116863766 C/T cg20608306 chr11:116969690 SIK3 -0.34 -6.5 -0.34 2.97e-10 Subjective well-being; CRC cis rs9660180 0.967 rs2272908 chr1:1721479 A/G cg03396347 chr1:1875803 NA 0.59 9.4 0.46 9.22e-19 Body mass index; CRC cis rs9311676 0.609 rs55797456 chr3:58378206 C/T cg06643156 chr3:58380774 PXK 0.41 6.2 0.32 1.67e-9 Systemic lupus erythematosus; CRC cis rs6570726 0.791 rs9373466 chr6:145912016 T/C cg05347473 chr6:146136440 FBXO30 0.38 5.71 0.3 2.52e-8 Lobe attachment (rater-scored or self-reported); CRC cis rs853679 1.000 rs7740487 chr6:28216486 C/G cg15786705 chr6:28176104 NA 0.63 6.06 0.32 3.78e-9 Depression; CRC cis rs7493 0.806 rs17876090 chr7:95053404 A/T cg01874867 chr7:94954059 PON1 -0.53 -6.58 -0.34 1.82e-10 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs9467773 0.935 rs1884947 chr6:26553273 G/T cg09904177 chr6:26538194 HMGN4 0.73 11.33 0.53 2.48e-25 Intelligence (multi-trait analysis); CRC cis rs13191362 1.000 rs73035025 chr6:163000988 T/C cg23758597 chr6:163146217 PARK2 -0.55 -6.12 -0.32 2.61e-9 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs860295 0.812 rs12024257 chr1:155780536 G/A cg02153340 chr1:155202674 NA -0.52 -6.21 -0.32 1.57e-9 Body mass index; CRC cis rs6684514 0.885 rs12036837 chr1:156283895 A/C cg16558208 chr1:156270281 VHLL 0.54 8.15 0.41 7.7e-15 Mean corpuscular hemoglobin concentration;Glycated hemoglobin levels; CRC cis rs713477 0.967 rs4901565 chr14:55912508 T/G cg13175173 chr14:55914753 NA -0.52 -9.79 -0.48 4.94e-20 Pediatric bone mineral content (femoral neck); CRC cis rs6761276 0.932 rs10186133 chr2:113836944 G/T cg24553058 chr2:113831203 IL1F10 0.38 5.82 0.31 1.4e-8 Protein quantitative trait loci; CRC cis rs951366 0.873 rs823118 chr1:205723572 C/T cg17178900 chr1:205818956 PM20D1 0.44 6.58 0.34 1.9e-10 Menarche (age at onset); CRC cis rs3858526 0.584 rs10769276 chr11:5868020 G/T cg13902645 chr11:5959945 NA -0.68 -9.67 -0.47 1.28e-19 DNA methylation (variation); CRC cis rs896854 0.684 rs10098778 chr8:95992020 C/T cg16049864 chr8:95962084 TP53INP1 -0.65 -11.97 -0.55 1.16e-27 Type 2 diabetes; CRC cis rs17376456 0.825 rs17372649 chr5:93126096 C/G cg21475434 chr5:93447410 FAM172A 0.71 6.79 0.35 5.34e-11 Diabetic retinopathy; CRC cis rs1670533 0.932 rs13108207 chr4:1054218 C/T cg27284194 chr4:1044797 NA 0.51 6.48 0.34 3.41e-10 Recombination rate (females); CRC cis rs17376456 0.825 rs10079708 chr5:93261796 G/C cg25358565 chr5:93447407 FAM172A 1.1 10.9 0.52 7.71e-24 Diabetic retinopathy; CRC trans rs4576506 0.536 rs13286245 chr9:31496532 T/A cg26940518 chr16:1593766 IFT140;TMEM204 -0.66 -6.11 -0.32 2.86e-9 Psychosis and Alzheimer's disease; CRC cis rs1003719 0.788 rs2835593 chr21:38465873 G/C cg10648535 chr21:38446584 PIGP;TTC3 0.52 7.4 0.38 1.11e-12 Eye color traits; CRC cis rs172166 0.652 rs476167 chr6:28065888 T/C cg25164649 chr6:28176230 NA 0.62 8.85 0.44 5.46e-17 Cardiac Troponin-T levels; CRC trans rs2797160 0.967 rs1777182 chr6:126013614 T/A cg05039488 chr6:79577232 IRAK1BP1 0.5 7.48 0.38 6.79e-13 Endometrial cancer; CRC cis rs2050392 0.557 rs306588 chr10:30723593 G/A cg18806716 chr10:30721971 MAP3K8 -0.7 -10.18 -0.49 2.39e-21 Inflammatory bowel disease; CRC cis rs929354 0.772 rs10228145 chr7:157007337 A/G cg17757837 chr7:157058334 UBE3C 0.75 12.89 0.58 4.83e-31 Body mass index; CRC cis rs7618915 0.570 rs11130319 chr3:52755592 A/T cg08222913 chr3:52553049 STAB1 -0.35 -6.22 -0.32 1.49e-9 Bipolar disorder; CRC cis rs4970988 0.787 rs1532770 chr1:150725335 G/T cg10589385 chr1:150898437 SETDB1 0.3 6.13 0.32 2.45e-9 Urate levels; CRC cis rs67311347 1.000 rs6599102 chr3:40468406 G/A cg09455208 chr3:40491958 NA 0.43 8.6 0.43 3.4e-16 Renal cell carcinoma; CRC cis rs929596 0.639 rs2070959 chr2:234602191 A/G cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.48 -7.03 -0.36 1.22e-11 Total bilirubin levels in HIV-1 infection; CRC cis rs4665809 0.556 rs1560869 chr2:26417095 T/C cg25036284 chr2:26402008 FAM59B -0.6 -7.65 -0.39 2.29e-13 Gut microbiome composition (summer); CRC cis rs72730918 0.564 rs2414112 chr15:51903024 C/T cg14296394 chr15:51910925 DMXL2 -0.45 -5.91 -0.31 8.53e-9 Intelligence (multi-trait analysis); CRC cis rs6570726 0.935 rs395948 chr6:145820185 G/A cg05347473 chr6:146136440 FBXO30 0.37 6.0 0.31 5.27e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs13082711 0.911 rs13078798 chr3:27445971 A/G cg02860705 chr3:27208620 NA -0.61 -9.03 -0.45 1.45e-17 Systolic blood pressure;Diastolic blood pressure;Blood pressure; CRC trans rs10983614 1.000 rs7867776 chr9:120072627 A/G cg12581662 chr19:36706085 ZNF565;ZNF146 0.43 6.18 0.32 1.92e-9 Survival in pancreatic cancer; CRC trans rs6561151 0.681 rs17065161 chr13:44443723 A/T cg17145862 chr1:211918768 LPGAT1 0.5 6.59 0.34 1.71e-10 Crohn's disease; CRC cis rs12477438 0.520 rs2516830 chr2:99773702 T/G cg26064155 chr2:99771622 LIPT1;TSGA10 0.77 13.13 0.59 5.79e-32 Chronic sinus infection; CRC cis rs10504229 1.000 rs59383954 chr8:58189689 G/A cg02290350 chr8:58132656 NA -0.42 -5.96 -0.31 6.62e-9 Developmental language disorder (linguistic errors); CRC cis rs1832871 0.672 rs9456285 chr6:158732819 T/G cg07165851 chr6:158734300 TULP4 0.63 7.96 0.4 2.75e-14 Height; CRC cis rs860295 0.627 rs11264410 chr1:155745349 G/A cg02153340 chr1:155202674 NA -0.53 -6.55 -0.34 2.21e-10 Body mass index; CRC cis rs12024301 0.557 rs12043560 chr1:183594102 G/T cg11505048 chr1:183622726 RGL1;APOBEC4 0.7 6.75 0.35 6.53e-11 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs62229266 0.682 rs11700546 chr21:37371139 A/C cg12218747 chr21:37451666 NA -0.39 -6.64 -0.34 1.27e-10 Mitral valve prolapse; CRC cis rs1223397 0.938 rs3734878 chr6:13288850 C/T cg21538684 chr6:13274180 PHACTR1 0.48 5.63 0.3 3.93e-8 Blood pressure; CRC cis rs769267 0.965 rs6511026 chr19:19391402 C/T cg20644253 chr19:19431407 KIAA0892;SF4 0.43 5.97 0.31 6e-9 Tonsillectomy; CRC cis rs972578 1.000 rs1569508 chr22:43359130 T/C cg01576275 chr22:43409880 NA -0.46 -7.47 -0.38 7.44e-13 Mean platelet volume; CRC cis rs79349575 0.783 rs12453394 chr17:46994970 G/A cg00947319 chr17:47005597 UBE2Z -0.34 -5.81 -0.3 1.5e-8 Type 2 diabetes; CRC cis rs7666738 0.830 rs35865860 chr4:98968822 C/T cg05340658 chr4:99064831 C4orf37 0.6 9.45 0.46 6.71e-19 Colonoscopy-negative controls vs population controls; CRC cis rs7647973 0.516 rs4536858 chr3:49193081 A/G cg20833759 chr3:49053208 WDR6;DALRD3 0.4 6.42 0.33 4.66e-10 Menarche (age at onset); CRC cis rs2952156 0.684 rs11658786 chr17:37815899 G/A cg00129232 chr17:37814104 STARD3 -0.71 -12.55 -0.57 8.52e-30 Asthma; CRC cis rs3785574 0.962 rs2584632 chr17:61880641 G/A cg06873352 chr17:61820015 STRADA 0.5 8.13 0.41 8.85e-15 Height; CRC trans rs6703335 0.870 rs10803142 chr1:243598234 A/G cg15368822 chr1:226070397 TMEM63A 0.43 5.98 0.31 5.68e-9 Schizophrenia;Schizophrenia, schizoaffective disorder or bipolar disorder; CRC cis rs1062746 0.527 rs35143469 chr16:87335483 T/C cg02258303 chr16:87377426 FBXO31 -0.49 -7.14 -0.37 6.2e-12 Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 2 peripheral neuropathy); CRC cis rs10078 0.898 rs2241598 chr5:438564 C/T cg08916839 chr5:415575 AHRR -0.52 -6.34 -0.33 7.45e-10 Fat distribution (HIV); CRC cis rs4713118 0.591 rs2056924 chr6:27690174 G/A cg21251018 chr6:28226885 NKAPL 0.38 5.97 0.31 6.16e-9 Parkinson's disease; CRC cis rs4728142 0.604 rs10239340 chr7:128668510 T/G cg06630958 chr7:128577819 IRF5 -0.35 -5.74 -0.3 2.14e-8 Inflammatory bowel disease;Systemic lupus erythematosus;Ulcerative colitis; CRC cis rs7254114 0.578 rs3745682 chr19:11313256 C/T cg02815516 chr19:11306319 KANK2 -0.35 -6.33 -0.33 8.07e-10 Immature fraction of reticulocytes; CRC cis rs67478160 0.643 rs3742369 chr14:104251276 T/C cg08213375 chr14:104286397 PPP1R13B 0.67 13.96 0.61 4.12e-35 Schizophrenia; CRC cis rs1046896 0.553 rs72634343 chr17:80827392 T/C cg17346650 chr17:80929145 B3GNTL1 0.49 7.38 0.38 1.29e-12 Glycated hemoglobin levels; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg18879991 chr6:27861393 HIST1H2AM;HIST1H2BO 0.54 8.44 0.42 9.95e-16 Liver disease severity in Alagille syndrome; CRC cis rs6960043 1.000 rs6980437 chr7:15054916 T/G cg19272540 chr7:15055459 NA -0.23 -6.22 -0.32 1.49e-9 Type 2 diabetes; CRC trans rs6044834 0.671 rs4239724 chr20:17445078 A/G cg24693218 chr3:170023372 PRKCI 0.48 6.01 0.31 4.92e-9 Obesity-related traits; CRC trans rs7615952 0.605 rs11708269 chr3:125332150 C/T cg00769240 chr8:12517080 NA -0.74 -6.64 -0.34 1.27e-10 Blood pressure (smoking interaction); CRC cis rs875971 0.830 rs587360 chr7:65522698 C/A cg18876405 chr7:65276391 NA 0.52 8.82 0.44 7e-17 Aortic root size; CRC cis rs6815814 0.898 rs5743562 chr4:38806096 T/C cg06935464 chr4:38784597 TLR10 0.57 5.97 0.31 6.19e-9 Breast cancer; CRC cis rs9902453 0.935 rs9911794 chr17:28349466 T/C cg26525008 chr17:28256777 EFCAB5;SSH2 -0.59 -8.86 -0.44 4.95e-17 Coffee consumption (cups per day); CRC cis rs3751196 0.708 rs77265338 chr12:104149689 G/A cg02344784 chr12:104178138 NT5DC3 0.68 6.33 0.33 8.16e-10 Sense of smell; CRC cis rs28830936 0.510 rs7175346 chr15:42100674 G/A cg17847044 chr15:42102381 MAPKBP1 -0.38 -9.26 -0.45 2.72e-18 Diastolic blood pressure; CRC cis rs73058052 0.531 rs3745475 chr19:50100295 A/G cg15963326 chr19:50037085 RCN3 -0.37 -5.84 -0.31 1.25e-8 Fibrinogen levels; CRC cis rs1163251 0.837 rs2764886 chr1:120241771 C/T cg19096424 chr1:120255104 PHGDH 0.41 5.85 0.31 1.16e-8 Blood metabolite levels; CRC cis rs875971 1.000 rs6961990 chr7:65888570 C/A cg00343986 chr7:65444356 GUSB 0.42 6.14 0.32 2.39e-9 Aortic root size; CRC cis rs17592366 0.517 rs10145350 chr14:35279109 A/C cg09327582 chr14:35236912 BAZ1A 0.45 6.03 0.32 4.34e-9 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells; CRC cis rs10504229 0.683 rs882429 chr8:58129292 A/G cg02290350 chr8:58132656 NA -0.58 -8.16 -0.41 7.29e-15 Developmental language disorder (linguistic errors); CRC cis rs1129187 0.755 rs28868299 chr6:42921221 T/G cg10862848 chr6:42927986 GNMT -0.38 -8.93 -0.44 3.04e-17 Alzheimer's disease in APOE e4+ carriers; CRC cis rs3751196 0.710 rs3812802 chr12:104215874 C/T cg02344784 chr12:104178138 NT5DC3 0.7 8.24 0.41 4.16e-15 Sense of smell; CRC cis rs2811415 0.627 rs9289325 chr3:127779693 A/C cg13719885 chr3:127795394 NA -0.39 -5.95 -0.31 6.69e-9 Lung function (FEV1/FVC); CRC cis rs539514 0.690 rs504273 chr13:76310850 C/T cg04757411 chr13:76259545 LMO7 -0.36 -6.05 -0.32 4.04e-9 Type 1 diabetes; CRC cis rs28386778 0.897 rs2584627 chr17:61901439 T/C cg23090583 chr17:61904693 PSMC5;FTSJ3 1.05 20.27 0.75 7.25e-60 Prudent dietary pattern; CRC cis rs853679 0.546 rs200953 chr6:27837267 T/C cg19041857 chr6:27730383 NA -0.76 -7.43 -0.38 9.26e-13 Depression; CRC cis rs7615952 0.641 rs61048217 chr3:125807905 G/T cg02772935 chr3:125709198 NA -0.5 -5.81 -0.3 1.5e-8 Blood pressure (smoking interaction); CRC cis rs28386778 0.863 rs3826341 chr17:61819222 C/A cg25654072 chr17:61904446 PSMC5;FTSJ3 0.7 10.84 0.51 1.31e-23 Prudent dietary pattern; CRC cis rs4803468 1.000 rs284655 chr19:41928765 C/T cg09537434 chr19:41945824 ATP5SL -0.97 -18.39 -0.71 1.96e-52 Height; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg27067234 chr6:107077272 RTN4IP1;QRSL1 0.5 6.91 0.36 2.57e-11 Anxiety disorder; CRC cis rs7552404 1.000 rs12126607 chr1:76217097 G/A cg10523679 chr1:76189770 ACADM 0.86 11.82 0.55 3.99e-27 Blood metabolite levels;Acylcarnitine levels; CRC trans rs17685 0.712 rs1637049 chr7:75729975 C/G cg19862616 chr7:65841803 NCRNA00174 1.0 18.87 0.72 2.33e-54 Coffee consumption;Coffee consumption (cups per day); CRC cis rs1003719 0.788 rs2835599 chr21:38466937 G/T cg10648535 chr21:38446584 PIGP;TTC3 0.52 7.42 0.38 1.03e-12 Eye color traits; CRC cis rs57590327 0.555 rs13088603 chr3:81791167 A/G cg07356753 chr3:81810745 GBE1 -0.66 -8.99 -0.44 1.93e-17 Extraversion; CRC cis rs4253772 0.614 rs11090859 chr22:46687460 T/G cg03482458 chr22:46692211 CN5H6.4;GTSE1 0.59 8.36 0.42 1.79e-15 LDL cholesterol;Cholesterol, total; CRC trans rs35110281 0.591 rs86139 chr21:44932802 G/A cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.46 7.49 0.38 6.2800000000000005e-13 Mean corpuscular volume; CRC cis rs1008375 1.000 rs1558378 chr4:17650351 T/C cg02297831 chr4:17616191 MED28 0.5 6.71 0.35 8.74e-11 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs950169 0.922 rs4842941 chr15:84831312 G/C cg11189052 chr15:85197271 WDR73 -0.63 -8.95 -0.44 2.65e-17 Schizophrenia; CRC cis rs6088580 0.634 rs1890000 chr20:32968312 G/T cg24642439 chr20:33292090 TP53INP2 -0.37 -6.27 -0.33 1.13e-9 Glomerular filtration rate (creatinine); CRC cis rs11608355 0.545 rs4766473 chr12:109900596 C/T cg05360138 chr12:110035743 NA 0.77 8.7 0.43 1.65e-16 Neuroticism; CRC cis rs60843830 0.662 rs6721594 chr2:305203 C/T cg25945732 chr2:264204 ACP1;SH3YL1 -0.57 -8.5 -0.42 6.57e-16 Spherical equivalent (joint analysis main effects and education interaction); CRC cis rs6860806 0.661 rs2136188 chr5:131577514 A/G cg02033258 chr5:131593261 PDLIM4 -0.4 -7.71 -0.39 1.56e-13 Breast cancer; CRC trans rs6550704 0.687 rs9865314 chr3:22634337 A/G cg01509451 chr4:1873985 WHSC1 -0.42 -6.08 -0.32 3.37e-9 Daytime sleep phenotypes; CRC trans rs1455244 0.700 rs7229302 chr18:11508904 G/T cg04305677 chr7:2281541 NUDT1;FTSJ2 0.39 6.13 0.32 2.48e-9 Schizophrenia; CRC cis rs9469890 0.604 rs11758426 chr6:34503338 A/G cg17674042 chr6:34482479 PACSIN1 -0.68 -8.75 -0.43 1.11e-16 Pubertal anthropometrics;Coronary artery disease; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg24861191 chr19:2740086 SLC39A3 0.43 6.29 0.33 1.02e-9 Intelligence (multi-trait analysis); CRC cis rs9914988 0.887 rs28873200 chr17:27149512 A/G cg16670446 chr17:27188758 MIR451;MIR144 0.53 8.4 0.42 1.32e-15 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs9926296 0.533 rs7190823 chr16:89866043 A/G cg04287289 chr16:89883240 FANCA 0.83 15.46 0.65 6.76e-41 Vitiligo; CRC cis rs1003719 0.645 rs8131944 chr21:38547215 G/A cg10648535 chr21:38446584 PIGP;TTC3 -0.48 -6.67 -0.35 1.08e-10 Eye color traits; CRC cis rs910316 0.763 rs13712 chr14:75483812 T/C cg03030879 chr14:75389066 RPS6KL1 -0.38 -5.75 -0.3 2.02e-8 Height; CRC cis rs9354308 0.933 rs2802064 chr6:66564352 C/T cg07460842 chr6:66804631 NA 0.47 5.9 0.31 9.09e-9 Metabolite levels; CRC cis rs6831352 0.918 rs29001203 chr4:100053091 A/G cg13256891 chr4:100009986 ADH5 -0.65 -8.9 -0.44 3.84e-17 Alcohol dependence; CRC cis rs72945132 0.882 rs7950916 chr11:70210001 T/C cg00319359 chr11:70116639 PPFIA1 0.55 6.04 0.32 4.16e-9 Coronary artery disease; CRC trans rs2303319 0.504 rs56009150 chr2:162598582 T/C cg06896663 chr8:82754093 SNX16 -0.69 -6.06 -0.32 3.82e-9 Cognitive function; CRC cis rs2839186 0.934 rs13049797 chr21:47707582 T/C cg02776659 chr21:47717406 C21orf57 -0.34 -5.62 -0.3 4.13e-8 Testicular germ cell tumor; CRC cis rs7615952 0.599 rs66532274 chr3:125731845 G/A cg02807482 chr3:125708958 NA -0.41 -5.73 -0.3 2.24e-8 Blood pressure (smoking interaction); CRC trans rs8002861 0.619 rs1337203 chr13:44423621 T/G cg17145862 chr1:211918768 LPGAT1 0.57 9.95 0.48 1.5e-20 Leprosy; CRC cis rs2635047 0.625 rs1836259 chr18:44732389 C/G cg19077165 chr18:44547161 KATNAL2 -0.41 -6.38 -0.33 6.18e-10 Educational attainment; CRC cis rs3931020 0.530 rs6668736 chr1:75234550 C/T cg17719053 chr1:75198211 TYW3;CRYZ 0.44 6.23 0.32 1.42e-9 Resistin levels; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg25431026 chr19:7701841 STXBP2 0.52 7.2 0.37 4.1e-12 Anxiety disorder; CRC trans rs2303319 0.504 rs12467625 chr2:162603387 C/A cg13490827 chr1:46269305 MAST2 -0.69 -6.0 -0.31 5.24e-9 Cognitive function; CRC cis rs9359856 0.564 rs17584290 chr6:90467114 T/G cg13799429 chr6:90582589 CASP8AP2 -0.75 -7.58 -0.39 3.44e-13 Bipolar disorder; CRC cis rs1552244 0.554 rs6762397 chr3:10007840 C/T cg18598329 chr3:10140678 FANCD2;C3orf24 -0.51 -7.28 -0.37 2.44e-12 Alzheimer's disease; CRC cis rs9868809 0.505 rs11706203 chr3:48746239 T/A cg00383909 chr3:49044727 WDR6 0.79 8.02 0.4 1.93e-14 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; CRC cis rs13191362 1.000 rs35383933 chr6:163002869 G/A cg23758597 chr6:163146217 PARK2 -0.55 -6.12 -0.32 2.61e-9 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs7849270 0.851 rs1819381 chr9:131908007 G/A cg13538475 chr9:131942899 NA -0.29 -5.73 -0.3 2.24e-8 Blood metabolite ratios; CRC cis rs727505 0.954 rs2054586 chr7:124708414 C/T cg23710748 chr7:124431027 NA -0.79 -13.83 -0.61 1.33e-34 Lewy body disease; CRC cis rs763014 0.966 rs7185390 chr16:666382 A/G cg04562611 chr16:615315 C16orf11 0.36 6.07 0.32 3.6e-9 Height; CRC cis rs752010 0.806 rs4641303 chr1:42091310 A/G cg06885757 chr1:42089581 HIVEP3 0.46 8.25 0.41 3.83e-15 Lupus nephritis in systemic lupus erythematosus; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg23763197 chr11:118965649 H2AFX 0.43 6.53 0.34 2.47e-10 Intelligence (multi-trait analysis); CRC cis rs9372498 0.536 rs9481808 chr6:118784571 G/A cg24463073 chr6:118973353 C6orf204 0.52 6.84 0.35 3.84e-11 Diastolic blood pressure; CRC cis rs950027 0.584 rs1145086 chr15:45654327 A/G cg21132104 chr15:45694354 SPATA5L1 0.42 6.0 0.31 5.3e-9 Response to fenofibrate (adiponectin levels); CRC cis rs929354 0.772 rs2301914 chr7:157000176 T/C cg05182265 chr7:156933206 UBE3C -0.76 -14.49 -0.62 3.69e-37 Body mass index; CRC cis rs8141529 0.719 rs6005916 chr22:29233342 T/C cg02153584 chr22:29168773 CCDC117 0.51 7.64 0.39 2.43e-13 Lymphocyte counts; CRC cis rs9462027 0.628 rs6924898 chr6:34811199 C/G cg07306190 chr6:34760872 UHRF1BP1 -0.34 -6.08 -0.32 3.4e-9 Systemic lupus erythematosus; CRC cis rs12497850 0.864 rs3212 chr3:49145741 T/C cg07636037 chr3:49044803 WDR6 1.0 16.33 0.67 2.51e-44 Parkinson's disease; CRC cis rs4474465 0.790 rs4544031 chr11:78265403 G/C cg02023728 chr11:77925099 USP35 -0.37 -6.33 -0.33 7.83e-10 Alzheimer's disease (survival time); CRC cis rs2836974 0.897 rs2836925 chr21:40532353 T/C cg06238570 chr21:40685208 BRWD1 0.74 10.4 0.5 4.41e-22 Cognitive function; CRC cis rs12701220 0.503 rs12702024 chr7:1129820 G/C cg26769984 chr7:1090371 C7orf50 0.51 6.3 0.33 9.3e-10 Bronchopulmonary dysplasia; CRC cis rs7662987 0.517 rs2602865 chr4:100034841 T/C cg12011299 chr4:100065546 ADH4 0.49 9.26 0.45 2.63e-18 Smoking initiation; CRC trans rs12702919 0.714 rs11760291 chr7:9550415 G/A cg15597424 chr4:24472487 NA -0.39 -6.04 -0.32 4.19e-9 PR interval in Tripanosoma cruzi seropositivity; CRC cis rs1832871 0.683 rs11756200 chr6:158657736 A/G cg07165851 chr6:158734300 TULP4 0.58 7.22 0.37 3.52e-12 Height; CRC cis rs9942416 0.660 rs166183 chr5:74977845 T/C cg00601450 chr5:74908170 NA -0.41 -5.77 -0.3 1.84e-8 Age-related disease endophenotypes; CRC cis rs11677370 0.574 rs12329183 chr2:3866943 G/A cg17052675 chr2:3827356 NA -0.68 -10.81 -0.51 1.6e-23 Type 2 diabetes; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg00605358 chr12:89747739 DUSP6 0.55 7.2 0.37 4.14e-12 Thyroid stimulating hormone; CRC cis rs10493773 0.609 rs11161651 chr1:86177816 A/G cg00734567 chr1:86172782 ZNHIT6 -0.46 -7.11 -0.37 7.17e-12 Urate levels in overweight individuals; CRC trans rs703108 0.731 rs7898954 chr10:22323646 A/G cg24483655 chr1:53686142 C1orf123 -0.51 -6.23 -0.32 1.42e-9 Monocyte percentage of white cells; CRC cis rs10751667 0.666 rs10902247 chr11:953686 G/A cg01483505 chr11:975446 AP2A2 0.45 7.44 0.38 9.1e-13 Alzheimer's disease (late onset); CRC cis rs765787 0.530 rs4775822 chr15:45527127 A/G cg24006582 chr15:45444508 DUOX1 -0.57 -8.61 -0.43 3.11e-16 Uric acid levels; CRC cis rs11677370 0.561 rs11687254 chr2:3830906 C/T cg17052675 chr2:3827356 NA -0.68 -11.46 -0.53 8.41e-26 Type 2 diabetes; CRC trans rs61931739 0.500 rs7979769 chr12:34509522 C/T cg26384229 chr12:38710491 ALG10B 0.67 8.88 0.44 4.28e-17 Morning vs. evening chronotype; CRC trans rs1814175 0.781 rs11040681 chr11:49981654 G/T cg11707556 chr5:10655725 ANKRD33B -0.42 -8.01 -0.4 2.02e-14 Height; CRC cis rs7223966 1.000 rs11658175 chr17:61923838 G/A cg23090583 chr17:61904693 PSMC5;FTSJ3 0.56 7.02 0.36 1.25e-11 Hip circumference adjusted for BMI;Body mass index; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg09093137 chr7:105028539 SRPK2 0.48 6.26 0.33 1.18e-9 Thyroid stimulating hormone; CRC cis rs737337 0.623 rs4804155 chr19:11334295 C/G cg00586551 chr19:11347513 LOC55908;DOCK6 0.89 11.01 0.52 3.38e-24 HDL cholesterol;HDL cholesterol levels; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg27611857 chr2:99347979 MGAT4A 0.4 6.3 0.33 9.66e-10 Intelligence (multi-trait analysis); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg02771843 chr3:69062953 C3orf64 0.41 6.62 0.34 1.46e-10 Liver disease severity in Alagille syndrome; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg04315863 chr15:34330588 AVEN;CHRM5 0.47 6.92 0.36 2.36e-11 Intelligence (multi-trait analysis); CRC cis rs12824058 0.831 rs7299065 chr12:130809661 A/T cg24838063 chr12:130822603 PIWIL1 0.58 9.77 0.47 5.67e-20 Menopause (age at onset); CRC trans rs10875746 0.859 rs12305511 chr12:48582716 C/T cg16281234 chr15:35388805 NA 0.49 6.32 0.33 8.53e-10 Longevity (90 years and older); CRC cis rs780096 0.546 rs1104 chr2:27599875 T/G cg02592271 chr2:27665507 KRTCAP3 -0.26 -5.97 -0.31 6e-9 Total body bone mineral density; CRC cis rs9443645 0.869 rs6913028 chr6:79513590 C/T cg09184832 chr6:79620586 NA -0.49 -9.04 -0.45 1.35e-17 Intelligence (multi-trait analysis); CRC cis rs1008375 1.000 rs62295634 chr4:17685346 C/A cg16339924 chr4:17578868 LAP3 0.54 7.29 0.37 2.31e-12 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs12681287 0.640 rs12679811 chr8:87465370 T/C cg27223183 chr8:87520930 FAM82B -0.52 -7.44 -0.38 8.7e-13 Caudate activity during reward; CRC cis rs7814319 0.674 rs2643339 chr8:97246978 C/A cg20787634 chr8:97240163 UQCRB -0.49 -8.32 -0.42 2.37e-15 Lung function (FVC); CRC cis rs11098499 0.599 rs3864142 chr4:120266191 A/T cg24375607 chr4:120327624 NA 0.47 7.68 0.39 1.89e-13 Corneal astigmatism; CRC cis rs2502731 0.539 rs3003615 chr9:130997892 C/T cg13642260 chr9:130955380 CIZ1 0.44 6.94 0.36 2.11e-11 Attention deficit hyperactivity disorder; CRC cis rs10504229 1.000 rs72650885 chr8:58175131 G/A cg24829409 chr8:58192753 C8orf71 -0.68 -11.34 -0.53 2.27e-25 Developmental language disorder (linguistic errors); CRC cis rs7258465 1.000 rs10413237 chr19:18548249 A/C cg10790698 chr19:18539756 SSBP4 -0.45 -8.46 -0.42 8.74e-16 Breast cancer; CRC cis rs2732480 0.538 rs1387260 chr12:48703091 A/C cg04545296 chr12:48745243 ZNF641 0.34 5.77 0.3 1.83e-8 Hemoglobin concentration;Red blood cell count;Hematocrit; CRC cis rs6479527 0.810 rs2153070 chr9:96751573 C/G cg13460858 chr9:96720652 NA 0.3 5.67 0.3 3.19e-8 Esophageal adenocarcinoma; CRC trans rs7671189 0.502 rs10939367 chr4:11740193 C/A cg18054620 chr5:111191530 C5orf13 -0.3 -6.03 -0.32 4.39e-9 Obesity-related traits; CRC cis rs329648 0.889 rs329647 chr11:133764666 G/C cg15485101 chr11:133734466 NA 0.37 6.09 0.32 3.17e-9 Parkinson's disease; CRC cis rs7727544 0.507 rs10051679 chr5:131570931 T/A cg24060327 chr5:131705240 SLC22A5 -0.41 -6.28 -0.33 1.07e-9 Blood metabolite levels; CRC trans rs11039798 0.588 rs584899 chr11:48431408 T/C cg15704280 chr7:45808275 SEPT13 -0.67 -7.39 -0.38 1.19e-12 Axial length; CRC cis rs13064411 0.696 rs3732803 chr3:113211957 T/C cg18753928 chr3:113234510 CCDC52 -0.7 -10.68 -0.51 4.62e-23 Response to simvastatin treatment (PCSK9 protein level change); CRC cis rs10979 1.000 rs9285500 chr6:143897614 G/C cg25407410 chr6:143891975 LOC285740 -0.84 -13.84 -0.61 1.22e-34 Hypospadias; CRC cis rs1129187 0.967 rs3805951 chr6:42937176 C/A cg02359409 chr6:42947317 PEX6 -0.59 -9.23 -0.45 3.5e-18 Alzheimer's disease in APOE e4+ carriers; CRC cis rs4713118 0.869 rs6902689 chr6:27709441 C/T cg12172441 chr6:28176163 NA 0.54 7.41 0.38 1.11e-12 Parkinson's disease; CRC cis rs7546094 1.000 rs10857963 chr1:113091487 C/T cg22162597 chr1:113214053 CAPZA1 0.43 5.93 0.31 7.67e-9 Platelet distribution width; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg03809994 chr4:75023664 MTHFD2L 0.41 6.58 0.34 1.88e-10 Liver disease severity in Alagille syndrome; CRC cis rs1443512 0.812 rs2044210 chr12:54335533 C/G cg17410650 chr12:54324560 NA -0.33 -6.07 -0.32 3.53e-9 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for BMI in non-smokers;Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction);Waist-hip ratio;Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour); CRC cis rs6502050 0.835 rs9900072 chr17:80114360 C/G cg02741985 chr17:80059408 CCDC57 0.43 7.2 0.37 4.16e-12 Life satisfaction; CRC cis rs881375 0.631 rs2416808 chr9:123706283 G/A cg09586646 chr9:123605570 PSMD5;LOC253039 0.44 6.59 0.34 1.7e-10 Rheumatoid arthritis; CRC cis rs11190604 1.000 rs10883510 chr10:102297018 C/T cg16342193 chr10:102329863 NA -0.38 -5.83 -0.31 1.33e-8 Palmitoleic acid (16:1n-7) levels; CRC cis rs1448094 0.706 rs10863149 chr12:86425498 A/T cg00310523 chr12:86230176 RASSF9 0.4 6.62 0.34 1.48e-10 Major depressive disorder; CRC cis rs9942416 0.517 rs116509898 chr5:74994361 C/T cg00601450 chr5:74908170 NA 0.41 5.76 0.3 1.95e-8 Age-related disease endophenotypes; CRC cis rs1448094 0.556 rs61930632 chr12:86168937 A/C cg00310523 chr12:86230176 RASSF9 0.4 6.53 0.34 2.54e-10 Major depressive disorder; CRC trans rs12478296 1.000 rs66612947 chr2:243035962 A/T cg18288967 chr1:45987694 PRDX1 0.69 7.62 0.39 2.75e-13 Obesity-related traits; CRC trans rs7618501 1.000 rs7431106 chr3:49808374 G/A cg21659725 chr3:3221576 CRBN 0.91 17.8 0.7 4.22e-50 Intelligence (multi-trait analysis); CRC cis rs9583531 0.689 rs4773244 chr13:111383937 A/T cg24331049 chr13:111365604 ING1 -0.54 -7.02 -0.36 1.3e-11 Coronary artery disease; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg00177013 chr20:62339100 ARFRP1;ZGPAT 0.5 7.2 0.37 4.02e-12 Response to antipsychotic treatment; CRC cis rs6700896 0.931 rs1938490 chr1:66132800 T/A cg04111102 chr1:66153794 NA 0.35 6.1 0.32 3.03e-9 C-reactive protein;Mean corpuscular volume;Mean corpuscular hemoglobin; CRC cis rs62458065 0.850 rs7808992 chr7:32470677 C/T cg20159608 chr7:32802032 NA -0.55 -6.56 -0.34 2.11e-10 Metabolite levels (HVA/MHPG ratio); CRC cis rs6565180 0.888 rs8060853 chr16:30403858 A/G cg01392867 chr16:30410429 ZNF48 0.38 6.03 0.32 4.51e-9 Tonsillectomy; CRC cis rs3809566 1.000 rs4775610 chr15:63332057 C/T cg05507819 chr15:63340323 TPM1 -0.45 -6.85 -0.35 3.68e-11 Platelet count; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg00106211 chr6:36514552 STK38 0.43 6.4 0.33 5.37e-10 Intelligence (multi-trait analysis); CRC cis rs17711722 1.000 rs17711722 chr7:65271197 C/T cg02869306 chr7:64672164 INTS4L1 0.34 5.63 0.3 3.96e-8 Calcium levels; CRC cis rs703842 0.575 rs701006 chr12:58106836 C/T cg15848620 chr12:58087721 OS9 0.5 6.96 0.36 1.83e-11 Multiple sclerosis; CRC cis rs7044106 0.762 rs966396 chr9:123453281 T/C cg09586646 chr9:123605570 PSMD5;LOC253039 0.62 8.76 0.43 1.04e-16 Hip circumference adjusted for BMI; CRC cis rs10986311 0.775 rs13300918 chr9:127145290 A/C cg14243010 chr9:127117328 LOC100129034;PSMB7 0.43 6.25 0.33 1.29e-9 Vitiligo; CRC trans rs7873102 0.702 rs7028020 chr9:38007747 C/T cg22263405 chr18:42259244 SETBP1 -0.36 -6.0 -0.31 5.3e-9 Brain structure; CRC cis rs6951245 0.706 rs28483034 chr7:1170171 C/A cg21664854 chr7:1097933 C7orf50;GPR146 0.69 8.24 0.41 4.07e-15 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs1957429 0.901 rs1951491 chr14:65346950 G/A cg23373153 chr14:65346875 NA 0.77 7.83 0.4 6.98e-14 Pediatric areal bone mineral density (radius); CRC cis rs67340775 0.541 rs200975 chr6:27855625 G/T cg06470822 chr6:28175283 NA 0.82 8.34 0.42 2.13e-15 Lung cancer in ever smokers; CRC cis rs7312933 0.618 rs12366848 chr12:42682215 A/G cg11827402 chr12:42719852 PPHLN1;ZCRB1 0.63 8.84 0.44 5.7e-17 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CRC cis rs801193 1.000 rs17566701 chr7:66193183 T/C cg18876405 chr7:65276391 NA 0.56 9.62 0.47 1.79e-19 Aortic root size; CRC cis rs6860806 0.507 rs273917 chr5:131659618 A/G cg11843238 chr5:131593191 PDLIM4 0.44 7.4 0.38 1.17e-12 Breast cancer; CRC cis rs4664293 0.967 rs7590607 chr2:160545635 T/C cg08347373 chr2:160653686 CD302 -0.38 -6.19 -0.32 1.83e-9 Monocyte percentage of white cells; CRC cis rs1448094 0.511 rs2405621 chr12:86149336 A/T cg19622623 chr12:86230825 RASSF9 0.41 6.47 0.34 3.54e-10 Major depressive disorder; CRC cis rs35306767 0.761 rs12770910 chr10:1050318 A/G cg26597838 chr10:835615 NA 0.95 11.2 0.53 6.98e-25 Eosinophil percentage of granulocytes; CRC cis rs798554 0.757 rs2533878 chr7:2878707 A/G cg13628971 chr7:2884303 GNA12 -0.54 -7.3 -0.37 2.21e-12 Height; CRC cis rs73206853 0.764 rs16940909 chr12:111054591 G/C cg12870014 chr12:110450643 ANKRD13A 0.76 9.26 0.45 2.73e-18 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC cis rs8103278 1.000 rs35302007 chr19:46219145 G/C cg14061069 chr19:46274453 DMPK -0.59 -8.96 -0.44 2.46e-17 Coronary artery disease; CRC cis rs4481887 0.927 rs7534188 chr1:248434303 C/T cg00666640 chr1:248458726 OR2T12 -0.54 -9.77 -0.47 5.59e-20 Common traits (Other); CRC cis rs8105895 0.935 rs7247041 chr19:22249790 G/A cg02657401 chr19:22469223 NA -0.34 -5.65 -0.3 3.56e-8 Body mass index (change over time); CRC cis rs4862750 0.794 rs7692427 chr4:187901727 G/A cg07414643 chr4:187882934 NA 0.39 6.95 0.36 1.94e-11 Lobe attachment (rater-scored or self-reported); CRC cis rs733592 0.560 rs2158515 chr12:48507668 T/C cg15465823 chr12:48382534 COL2A1 -0.34 -5.62 -0.3 4.13e-8 Plateletcrit; CRC cis rs59698941 0.527 rs1910075 chr5:132180089 A/T cg14825688 chr5:132208181 LEAP2 -0.38 -5.92 -0.31 8.21e-9 Apolipoprotein A-IV levels; CRC cis rs853679 0.517 rs4713150 chr6:28136212 G/A cg15786705 chr6:28176104 NA 0.78 9.71 0.47 9.33e-20 Depression; CRC cis rs9388451 0.536 rs34725880 chr6:126155237 A/G cg05901451 chr6:126070800 HEY2 -0.4 -5.84 -0.31 1.24e-8 Brugada syndrome; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg27554509 chr20:61847579 YTHDF1 0.45 6.5 0.34 2.98e-10 Anxiety disorder; CRC cis rs2576037 0.583 rs530205 chr18:44385150 C/T cg19077165 chr18:44547161 KATNAL2 -0.6 -9.81 -0.48 4.36e-20 Personality dimensions; CRC cis rs7824557 0.505 rs2736313 chr8:11086942 C/T cg27411982 chr8:10470053 RP1L1 0.36 5.62 0.3 4.01e-8 Retinal vascular caliber; CRC cis rs10861342 1.000 rs10861354 chr12:105524294 T/C cg23923672 chr12:105501055 KIAA1033 0.6 5.79 0.3 1.64e-8 IgG glycosylation; CRC trans rs2727020 0.521 rs11040377 chr11:49474346 T/C cg11707556 chr5:10655725 ANKRD33B -0.35 -6.39 -0.33 5.59e-10 Coronary artery disease; CRC trans rs7726839 0.540 rs58599998 chr5:596087 A/G cg11887960 chr12:57824829 NA 0.59 6.66 0.34 1.15e-10 Obesity-related traits; CRC cis rs6922632 0.867 rs6934526 chr6:24114746 G/C cg26194775 chr6:24126114 NRSN1 -0.62 -7.23 -0.37 3.37e-12 Information processing speed; CRC cis rs10992471 0.651 rs13296623 chr9:95301627 T/C cg14631576 chr9:95140430 CENPP -0.31 -5.88 -0.31 1.01e-8 Visceral adipose tissue/subcutaneous adipose tissue ratio; CRC cis rs9372498 0.536 rs9489477 chr6:118946192 T/G cg01339444 chr6:118972232 C6orf204 0.54 6.01 0.31 4.89e-9 Diastolic blood pressure; CRC cis rs919433 0.890 rs979020 chr2:198169749 T/C cg03934865 chr2:198174659 NA -0.45 -7.73 -0.39 1.34e-13 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC trans rs10983614 1.000 rs7867776 chr9:120072627 A/G cg00319567 chr13:60971258 TDRD3 0.52 7.01 0.36 1.33e-11 Survival in pancreatic cancer; CRC cis rs9916302 0.706 rs4287601 chr17:37513852 T/C cg00129232 chr17:37814104 STARD3 0.58 7.09 0.36 8.09e-12 Glomerular filtration rate (creatinine); CRC cis rs2836974 0.583 rs2410124 chr21:40704760 C/G cg11890956 chr21:40555474 PSMG1 -0.83 -13.33 -0.59 1.06e-32 Cognitive function; CRC cis rs7586673 0.930 rs6432667 chr2:161905001 T/C cg22496339 chr2:162101262 NA 0.59 8.1 0.41 1.09e-14 Intelligence (multi-trait analysis); CRC cis rs7412746 0.658 rs11589458 chr1:150792616 A/G cg15448220 chr1:150897856 SETDB1 0.56 8.01 0.4 1.94e-14 Melanoma; CRC cis rs4862750 0.872 rs4862747 chr4:187877236 A/T cg22105103 chr4:187893119 NA -0.65 -12.19 -0.56 1.87e-28 Lobe attachment (rater-scored or self-reported); CRC cis rs2153535 0.580 rs1335628 chr6:8491742 A/T cg21535247 chr6:8435926 SLC35B3 0.5 7.54 0.38 4.72e-13 Motion sickness; CRC cis rs11677416 1.000 rs1516790 chr2:113531291 G/A cg06156847 chr2:113672199 IL1F7 -0.38 -5.67 -0.3 3.13e-8 Response to antipsychotic treatment in schizophrenia (working memory); CRC cis rs6933660 0.745 rs9397405 chr6:151736084 G/T cg14416726 chr6:151773293 C6orf211;RMND1 -0.58 -8.85 -0.44 5.64e-17 Menarche (age at onset); CRC cis rs5758659 0.652 rs133322 chr22:42405659 A/G cg04733989 chr22:42467013 NAGA 0.4 5.62 0.3 4.12e-8 Cognitive function; CRC cis rs4474465 0.850 rs10793323 chr11:78244170 C/T cg27205649 chr11:78285834 NARS2 0.47 6.11 0.32 2.79e-9 Alzheimer's disease (survival time); CRC cis rs4760636 0.648 rs12818241 chr12:48157019 A/G cg13326926 chr12:48153388 RAPGEF3 -0.61 -6.11 -0.32 2.75e-9 Urate levels; CRC cis rs754466 0.580 rs1344966 chr10:79534527 T/C cg26805224 chr10:79626177 DLG5 -0.49 -7.31 -0.37 2.02e-12 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs10486722 0.651 rs2190336 chr7:41801254 A/G cg22138096 chr7:41772439 LOC285954 0.62 7.46 0.38 8.01e-13 Pit-and-Fissure caries; CRC cis rs1915146 0.546 rs2681919 chr10:126859029 A/G cg05090351 chr10:126851162 NA 0.55 7.68 0.39 1.86e-13 Menarche (age at onset); CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg22691505 chr7:6312217 CYTH3 0.42 6.92 0.36 2.33e-11 Obesity-related traits; CRC cis rs4819852 0.958 rs9606203 chr22:19972118 C/A cg07821417 chr22:19972146 ARVCF 0.45 6.08 0.32 3.42e-9 Pulse pressure; CRC cis rs4638749 0.953 rs4676033 chr2:108869368 G/A cg25838818 chr2:108905173 SULT1C2 -0.37 -6.07 -0.32 3.57e-9 Blood pressure; CRC cis rs12050794 0.671 rs62022788 chr15:72559326 T/G cg16672083 chr15:72433130 SENP8 0.47 7.12 0.37 6.96e-12 Metabolite levels (HVA/MHPG ratio); CRC trans rs6499188 1.000 rs6499188 chr16:68674788 G/A cg04657470 chr2:198365150 HSPE1;HSPD1 0.6 7.96 0.4 2.83e-14 Ulcerative colitis; CRC cis rs13394619 0.875 rs7576826 chr2:11723021 C/T cg07314298 chr2:11723111 GREB1 -0.46 -7.65 -0.39 2.22e-13 Endometriosis; CRC trans rs11039798 0.588 rs10838979 chr11:48626810 T/G cg03929089 chr4:120376271 NA 0.67 7.17 0.37 5.14e-12 Axial length; CRC cis rs13394619 1.000 rs4669752 chr2:11727988 G/C cg07314298 chr2:11723111 GREB1 -0.49 -8.2 -0.41 5.39e-15 Endometriosis; CRC cis rs2565722 0.825 rs2489928 chr6:161256391 A/G cg03159191 chr6:161285451 NA -0.49 -5.97 -0.31 6.27e-9 Blood protein levels; CRC cis rs1044826 0.619 rs57357132 chr3:139118358 A/T cg15131784 chr3:139108705 COPB2 -0.41 -5.94 -0.31 7.11e-9 Obesity-related traits; CRC cis rs798554 1.000 rs798554 chr7:2759795 C/T cg19717773 chr7:2847554 GNA12 -0.46 -6.78 -0.35 5.43e-11 Height; CRC cis rs3789045 0.774 rs12041243 chr1:204490470 A/G cg17419461 chr1:204415978 PIK3C2B -0.57 -7.95 -0.4 3.06e-14 Educational attainment (college completion); CRC cis rs4713118 0.869 rs9295743 chr6:27715102 G/C cg21251018 chr6:28226885 NKAPL 0.38 5.73 0.3 2.24e-8 Parkinson's disease; CRC trans rs1945213 0.694 rs1384088 chr11:55848713 G/C cg15704280 chr7:45808275 SEPT13 -0.57 -6.52 -0.34 2.64e-10 Acute lymphoblastic leukemia (childhood); CRC cis rs875971 0.508 rs10950045 chr7:66066373 T/C cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.42 -6.22 -0.32 1.55e-9 Aortic root size; CRC cis rs62408225 1.000 rs11757155 chr6:90941240 C/T cg06866423 chr6:90926672 BACH2 0.51 8.25 0.41 3.92e-15 Eosinophil counts;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC cis rs875971 0.964 rs2277911 chr7:65958625 T/G cg18912574 chr7:65842487 NCRNA00174 0.36 6.1 0.32 2.99e-9 Aortic root size; CRC cis rs6500602 0.627 rs860891 chr16:4586529 C/T cg13763550 chr16:4524223 NMRAL1;HMOX2 -0.41 -5.65 -0.3 3.46e-8 Schizophrenia; CRC cis rs9522267 0.535 rs11069897 chr13:112231319 A/G cg26182253 chr13:112236782 NA 0.31 6.25 0.33 1.26e-9 Hepatitis; CRC cis rs9858213 1 rs9858213 chr3:49731861 G/T cg03060546 chr3:49711283 APEH -0.54 -7.29 -0.37 2.37e-12 Educational attainment; CRC cis rs11608355 0.515 rs1045582 chr12:109915727 G/T cg05360138 chr12:110035743 NA 0.77 8.62 0.43 2.95e-16 Neuroticism; CRC trans rs853679 0.607 rs200489 chr6:27798257 T/C cg06606381 chr12:133084897 FBRSL1 -0.77 -6.62 -0.34 1.45e-10 Depression; CRC cis rs7584330 0.554 rs729388 chr2:238425004 G/C cg14458575 chr2:238380390 NA 0.46 6.53 0.34 2.51e-10 Prostate cancer; CRC cis rs2463822 1.000 rs2513071 chr11:62098387 A/C cg06239285 chr11:62104954 ASRGL1 0.97 11.38 0.53 1.58e-25 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs2976388 0.609 rs2572899 chr8:143785549 A/G cg12516270 chr8:143859308 LYNX1 0.44 7.77 0.39 9.84e-14 Urinary tract infection frequency; CRC cis rs2380220 0.808 rs2716074 chr6:95907662 T/C cg04719120 chr6:96025338 MANEA -0.53 -5.88 -0.31 9.93e-9 Behavioural disinhibition (generation interaction); CRC cis rs8141529 0.632 rs5762803 chr22:29193638 G/C cg02153584 chr22:29168773 CCDC117 0.54 7.8 0.4 8.22e-14 Lymphocyte counts; CRC cis rs6570726 0.791 rs10872577 chr6:145900560 G/T cg05347473 chr6:146136440 FBXO30 0.38 5.86 0.31 1.15e-8 Lobe attachment (rater-scored or self-reported); CRC trans rs2303319 0.504 rs961421 chr2:162626099 G/C cg22902534 chr3:183892754 AP2M1 -0.7 -6.07 -0.32 3.56e-9 Cognitive function; CRC cis rs34779708 0.801 rs12255409 chr10:35535425 G/A cg03585969 chr10:35415529 CREM 0.55 7.02 0.36 1.25e-11 Inflammatory bowel disease;Crohn's disease; CRC cis rs4481887 0.732 rs6703399 chr1:248416343 T/C cg00666640 chr1:248458726 OR2T12 0.55 9.65 0.47 1.45e-19 Common traits (Other); CRC cis rs769267 0.929 rs34538000 chr19:19481379 G/T cg02546618 chr19:19431379 KIAA0892;SF4 -0.45 -6.25 -0.33 1.29e-9 Tonsillectomy; CRC cis rs8044995 0.706 rs111948678 chr16:68255959 G/A cg26727032 chr16:67993705 SLC12A4 -0.59 -6.31 -0.33 9.1e-10 Schizophrenia; CRC cis rs501120 1.000 rs554568 chr10:44755446 C/T cg09554077 chr10:44749378 NA 0.89 13.32 0.59 1.14e-32 Coronary artery disease;Coronary heart disease; CRC cis rs12497850 0.931 rs6442130 chr3:48778027 A/G cg07636037 chr3:49044803 WDR6 0.96 15.86 0.66 1.74e-42 Parkinson's disease; CRC cis rs6424115 0.830 rs3003335 chr1:24200052 A/G cg15997130 chr1:24165203 NA 0.72 10.57 0.5 1.09e-22 Immature fraction of reticulocytes; CRC trans rs35110281 0.744 rs162396 chr21:44947807 T/C cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.43 6.84 0.35 3.85e-11 Mean corpuscular volume; CRC cis rs1552244 0.882 rs3755782 chr3:10029305 T/C cg00166722 chr3:10149974 C3orf24 0.61 7.92 0.4 3.81e-14 Alzheimer's disease; CRC trans rs629535 0.590 rs55988608 chr8:70133619 A/G cg21567404 chr3:27674614 NA -0.92 -13.67 -0.6 5.38e-34 Dupuytren's disease; CRC cis rs9926296 0.509 rs2159113 chr16:89832083 C/T cg04287289 chr16:89883240 FANCA 0.66 10.56 0.5 1.22e-22 Vitiligo; CRC cis rs7772486 0.875 rs863820 chr6:146347402 C/T cg23711669 chr6:146136114 FBXO30 -0.64 -11.16 -0.52 9.95e-25 Lobe attachment (rater-scored or self-reported); CRC trans rs6550704 0.687 rs9865314 chr3:22634337 A/G cg22653602 chr6:90529138 MDN1 -0.46 -7.03 -0.36 1.2e-11 Daytime sleep phenotypes; CRC cis rs1153858 1.000 rs11070456 chr15:45686835 G/A cg10760299 chr15:45669010 GATM 0.5 7.74 0.39 1.26e-13 Homoarginine levels; CRC cis rs1153858 1.000 rs1346268 chr15:45673029 T/C cg21132104 chr15:45694354 SPATA5L1 0.59 8.56 0.43 4.47e-16 Homoarginine levels; CRC cis rs2836974 0.666 rs1888487 chr21:40683259 A/G cg11890956 chr21:40555474 PSMG1 -0.9 -15.29 -0.64 3.08e-40 Cognitive function; CRC cis rs8180040 0.900 rs4858894 chr3:47484953 C/G cg27129171 chr3:47204927 SETD2 0.52 8.17 0.41 6.93e-15 Colorectal cancer; CRC cis rs4654899 0.931 rs935917 chr1:21167102 A/T cg02927042 chr1:21476669 EIF4G3 -0.42 -6.7 -0.35 8.88e-11 Superior frontal gyrus grey matter volume; CRC cis rs7523050 0.730 rs11102650 chr1:109464228 C/G cg08274380 chr1:109419600 GPSM2 0.72 6.4 0.33 5.31e-10 Fat distribution (HIV); CRC cis rs2404602 0.716 rs1588961 chr15:76752698 A/G cg23625390 chr15:77176239 SCAPER 0.5 7.38 0.38 1.29e-12 Blood metabolite levels; CRC cis rs7666738 0.753 rs1830230 chr4:99026186 G/C cg05340658 chr4:99064831 C4orf37 0.6 9.19 0.45 4.67e-18 Colonoscopy-negative controls vs population controls; CRC cis rs4909189 1.000 rs4909189 chr7:158136986 A/T cg24154853 chr7:158122151 PTPRN2 -0.53 -7.97 -0.4 2.69e-14 Response to amphetamines; CRC cis rs801193 1.000 rs2659909 chr7:66160279 G/A cg11764359 chr7:65958608 NA 0.54 8.43 0.42 1.12e-15 Aortic root size; CRC cis rs6951245 0.554 rs78999139 chr7:1138525 G/A cg21664854 chr7:1097933 C7orf50;GPR146 0.58 7.34 0.37 1.72e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs2243480 1.000 rs35820085 chr7:65442758 C/T cg18252515 chr7:66147081 NA -1.08 -12.36 -0.56 4.53e-29 Diabetic kidney disease; CRC cis rs6964587 1.000 rs4727266 chr7:91570129 C/T cg17063962 chr7:91808500 NA -0.78 -13.48 -0.6 2.8e-33 Breast cancer; CRC cis rs61008539 0.586 rs6959154 chr7:856320 C/T cg00934597 chr7:893267 UNC84A -0.54 -7.47 -0.38 7.21e-13 Perceived unattractiveness to mosquitoes; CRC cis rs514406 0.505 rs437954 chr1:53173321 C/G cg08859206 chr1:53392774 SCP2 -0.41 -6.25 -0.33 1.28e-9 Monocyte count; CRC cis rs898097 0.841 rs4986122 chr17:80825500 C/T cg03160526 chr17:80928410 B3GNTL1 -0.44 -6.64 -0.34 1.3e-10 Breast cancer; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg04421424 chr19:57791681 ZNF460 0.47 6.01 0.31 5.04e-9 Thyroid stimulating hormone; CRC cis rs2075371 0.829 rs11770521 chr7:133936251 A/C cg02659138 chr7:134003124 SLC35B4 0.39 6.49 0.34 3.14e-10 Mean platelet volume; CRC cis rs6582630 0.519 rs1851130 chr12:38507819 C/T cg26384229 chr12:38710491 ALG10B 0.71 9.99 0.48 1.05e-20 Drug-induced liver injury (flucloxacillin); CRC cis rs9467711 0.606 rs9348709 chr6:26360311 G/A cg14345882 chr6:26364793 BTN3A2 0.64 5.63 0.3 3.85e-8 Autism spectrum disorder or schizophrenia; CRC cis rs13118159 0.714 rs6843025 chr4:1334418 C/G cg02018176 chr4:1364513 KIAA1530 0.4 6.59 0.34 1.79e-10 Longevity; CRC cis rs853679 0.517 rs9348796 chr6:28126202 A/G cg02683197 chr6:28174875 NA 0.87 10.73 0.51 3.25e-23 Depression; CRC cis rs9807989 1.000 rs9807989 chr2:102971200 T/C cg03938978 chr2:103052716 IL18RAP 0.37 5.97 0.31 6.2e-9 Asthma; CRC cis rs4713118 0.662 rs156744 chr6:27967274 G/A cg15845792 chr6:28175446 NA 0.86 12.78 0.58 1.16e-30 Parkinson's disease; CRC cis rs4664293 0.867 rs1427328 chr2:160618575 A/G cg08347373 chr2:160653686 CD302 -0.47 -7.43 -0.38 9.32e-13 Monocyte percentage of white cells; CRC cis rs12541335 0.639 rs11779277 chr8:22200683 C/T cg14487702 chr8:22132665 PIWIL2 0.38 5.77 0.3 1.86e-8 Hypertriglyceridemia; CRC cis rs10463316 0.894 rs869196 chr5:150746287 G/T cg03212797 chr5:150827313 SLC36A1 -0.49 -7.48 -0.38 6.85e-13 Metabolite levels (Pyroglutamine); CRC cis rs2721195 0.967 rs748195 chr8:145682514 T/C cg11211951 chr8:145729740 GPT 0.42 7.41 0.38 1.11e-12 Age at first birth; CRC cis rs6539267 0.847 rs17217845 chr12:106697802 C/T cg00173435 chr12:106696525 TCP11L2 -0.47 -5.89 -0.31 9.29e-9 Tourette syndrome; CRC cis rs12745968 0.653 rs6604013 chr1:93192134 A/G cg17283838 chr1:93427260 FAM69A -0.44 -5.99 -0.31 5.4e-9 Bipolar disorder and schizophrenia; CRC cis rs6582630 0.519 rs8189623 chr12:38351436 G/A cg13010199 chr12:38710504 ALG10B 0.47 6.3 0.33 9.67e-10 Drug-induced liver injury (flucloxacillin); CRC cis rs4604732 0.631 rs60311891 chr1:247623127 C/T cg12758973 chr1:247694275 LOC148824;OR2C3 0.42 6.01 0.31 4.99e-9 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CRC cis rs270601 0.770 rs1007602 chr5:131602166 T/C cg22638593 chr5:131593259 PDLIM4 0.49 9.08 0.45 1.05e-17 Acylcarnitine levels; CRC cis rs801193 1.000 rs2286684 chr7:66129830 G/T cg18876405 chr7:65276391 NA -0.61 -10.75 -0.51 2.66e-23 Aortic root size; CRC cis rs6502050 0.769 rs8068708 chr17:80120424 T/C cg19223190 chr17:80058835 NA 0.39 6.3 0.33 9.57e-10 Life satisfaction; CRC trans rs2303319 0.504 rs62187571 chr2:162374319 A/G cg18122310 chr12:50236657 BCDIN3D -0.72 -6.07 -0.32 3.54e-9 Cognitive function; CRC trans rs3794271 0.706 rs9971816 chr12:20826911 C/T cg13714271 chr9:33076774 SMU1 0.44 6.11 0.32 2.75e-9 Response to TNF-alpha inhibitors in rheumatoid arthritis; CRC cis rs7493 1.000 rs17876123 chr7:95045307 C/A cg17330251 chr7:94953956 PON1 -0.59 -7.5 -0.38 5.82e-13 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs10242455 0.571 rs7805661 chr7:99171522 A/C cg18809830 chr7:99032528 PTCD1 -1.08 -7.99 -0.4 2.29e-14 Blood metabolite levels; CRC cis rs62244186 0.748 rs6441861 chr3:44652287 A/G cg11003573 chr3:44754125 ZNF502 -0.35 -5.96 -0.31 6.56e-9 Depressive symptoms; CRC cis rs1799949 1.000 rs2271573 chr17:41327621 A/G cg01879757 chr17:41196368 BRCA1 -0.42 -6.17 -0.32 2.05e-9 Menopause (age at onset); CRC cis rs644799 0.930 rs587123 chr11:95560539 T/G cg25622487 chr11:95524042 FAM76B;CEP57 0.76 11.99 0.55 9.59e-28 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs13256369 0.755 rs12680167 chr8:8562467 A/G cg17143192 chr8:8559678 CLDN23 0.52 6.68 0.35 1.04e-10 Obesity-related traits; CRC cis rs924607 0.931 rs1709556 chr5:637058 A/G cg09021430 chr5:549028 NA -0.51 -8.45 -0.42 9.25e-16 Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia; CRC cis rs77633900 0.614 rs2439982 chr15:76925071 T/G cg21673338 chr15:77095150 SCAPER -0.76 -8.03 -0.4 1.79e-14 Non-glioblastoma glioma;Glioma; CRC cis rs6598955 0.670 rs6663950 chr1:26560131 T/C cg04990556 chr1:26633338 UBXN11 -0.79 -13.15 -0.59 4.94e-32 Obesity-related traits; CRC cis rs881375 1.000 rs7037140 chr9:123656327 T/C cg00246817 chr9:123691163 NA -0.46 -5.85 -0.31 1.16e-8 Rheumatoid arthritis; CRC cis rs7267979 0.789 rs6050472 chr20:25219852 A/G cg13962466 chr20:25176127 ENTPD6 0.41 6.32 0.33 8.62e-10 Liver enzyme levels (alkaline phosphatase); CRC cis rs9479482 1.000 rs9478354 chr6:150334366 G/A cg25797454 chr6:150327115 RAET1K 0.38 6.35 0.33 7.14e-10 Alopecia areata; CRC cis rs7618501 0.635 rs34080578 chr3:50026029 A/C cg24110177 chr3:50126178 RBM5 -0.46 -6.84 -0.35 3.94e-11 Intelligence (multi-trait analysis); CRC trans rs1814175 0.546 rs1614397 chr11:49913384 G/C cg03929089 chr4:120376271 NA -0.94 -17.84 -0.7 2.9e-50 Height; CRC cis rs9311474 0.629 rs7636227 chr3:52566682 G/A cg15147215 chr3:52552868 STAB1 -0.77 -15.99 -0.66 5.33e-43 Electroencephalogram traits; CRC cis rs2739330 0.760 rs1002286 chr22:24257337 A/G cg23131131 chr22:24373011 LOC391322 0.61 9.59 0.47 2.33e-19 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs694739 0.628 rs508168 chr11:64135435 G/A cg23796481 chr11:64053134 BAD;GPR137 0.49 6.92 0.36 2.33e-11 Alopecia areata;Crohn's disease;Psoriasis vulgaris; CRC cis rs4243830 0.850 rs4908911 chr1:6599523 C/T cg05709478 chr1:6581295 PLEKHG5 -0.5 -5.69 -0.3 2.83e-8 Body mass index; CRC cis rs6499255 0.951 rs8054096 chr16:69695886 G/A cg15192750 chr16:69999425 NA 0.57 7.69 0.39 1.75e-13 IgE levels; CRC cis rs3018066 0.867 rs3109960 chr4:107214171 T/C cg01869342 chr4:106983673 TBCK 0.37 5.69 0.3 2.83e-8 Cancer; CRC cis rs2404602 1.000 rs2120107 chr15:76869789 A/G cg23625390 chr15:77176239 SCAPER 0.56 8.71 0.43 1.53e-16 Blood metabolite levels; CRC cis rs9322193 0.962 rs7740784 chr6:150154500 C/T cg05861140 chr6:150128134 PCMT1 -0.41 -6.21 -0.32 1.61e-9 Lung cancer; CRC cis rs2806561 0.664 rs4620508 chr1:23307438 C/T cg12483005 chr1:23474871 LUZP1 0.45 6.41 0.33 5.04e-10 Height; CRC cis rs11690935 0.959 rs10194102 chr2:172626143 G/C cg13550731 chr2:172543902 DYNC1I2 -1.06 -17.46 -0.69 9.32e-49 Schizophrenia; CRC cis rs12476592 0.571 rs7577952 chr2:63787212 C/T cg10828910 chr2:63850056 LOC388955 0.49 6.11 0.32 2.79e-9 Childhood ear infection; CRC cis rs7615952 0.599 rs60847438 chr3:125746005 T/C cg02807482 chr3:125708958 NA -0.45 -5.65 -0.3 3.39e-8 Blood pressure (smoking interaction); CRC cis rs11971779 0.648 rs9642121 chr7:139092621 G/A cg07862535 chr7:139043722 LUC7L2 0.57 7.35 0.38 1.61e-12 Diisocyanate-induced asthma; CRC cis rs6912958 0.684 rs6931069 chr6:88367082 C/T cg12350822 chr6:88032061 C6orf162;GJB7 -0.3 -5.75 -0.3 2.06e-8 Monocyte percentage of white cells; CRC cis rs10883723 0.737 rs7074444 chr10:104249922 A/G cg22532475 chr10:104410764 TRIM8 -0.37 -6.8 -0.35 4.94e-11 Allergic disease (asthma, hay fever or eczema); CRC cis rs2227564 0.729 rs2688611 chr10:75653372 G/T cg00564723 chr10:75632066 CAMK2G -0.33 -7.63 -0.39 2.58e-13 Crohn's disease;Inflammatory bowel disease; CRC trans rs2727020 0.729 rs6485965 chr11:49166730 C/T cg21153622 chr11:89784906 NA 0.43 7.04 0.36 1.13e-11 Coronary artery disease; CRC cis rs477692 0.563 rs7079165 chr10:131430240 G/A cg05714579 chr10:131428358 MGMT -0.8 -12.28 -0.56 8.52e-29 Response to temozolomide; CRC trans rs7824557 0.872 rs2572431 chr8:11105077 C/T cg06636001 chr8:8085503 FLJ10661 -0.43 -6.39 -0.33 5.83e-10 Retinal vascular caliber; CRC cis rs10504229 0.774 rs72650880 chr8:58164727 C/T cg22535103 chr8:58192502 C8orf71 -0.78 -9.05 -0.45 1.32e-17 Developmental language disorder (linguistic errors); CRC cis rs4588572 0.643 rs9293747 chr5:77705567 A/G cg11547950 chr5:77652471 NA -0.5 -6.95 -0.36 1.97e-11 Triglycerides; CRC cis rs3785574 0.962 rs2665840 chr17:61873307 C/T cg11494091 chr17:61959527 GH2 -0.41 -6.48 -0.34 3.3e-10 Height; CRC cis rs1983170 1.000 rs483532 chr1:91980447 A/G cg02896835 chr1:92012615 NA -0.48 -6.25 -0.33 1.27e-9 Eosinophil percentage of white cells; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg13086606 chr15:69452796 MIR548H4;GLCE 0.42 6.03 0.32 4.34e-9 Response to antipsychotic treatment; CRC trans rs2303319 0.504 rs1449641 chr2:162619567 T/C cg22922770 chr7:98923339 ARPC1A -0.67 -5.99 -0.31 5.55e-9 Cognitive function; CRC cis rs7666738 0.791 rs10856934 chr4:99010844 A/G cg05340658 chr4:99064831 C4orf37 -0.61 -9.57 -0.47 2.58e-19 Colonoscopy-negative controls vs population controls; CRC cis rs7224685 0.501 rs781845 chr17:3958341 A/G cg05562828 chr17:3906858 NA -0.65 -11.81 -0.55 4.68e-27 Type 2 diabetes; CRC trans rs17685 0.712 rs10275521 chr7:75770972 T/C cg19862616 chr7:65841803 NCRNA00174 0.99 18.11 0.71 2.51e-51 Coffee consumption;Coffee consumption (cups per day); CRC cis rs7833986 0.501 rs2719255 chr8:57036658 A/G cg23139584 chr8:56987506 RPS20;SNORD54 0.92 11.98 0.55 1.1e-27 Height; CRC cis rs9549328 0.589 rs34144481 chr13:113617322 T/G cg17524180 chr13:113633600 MCF2L 0.52 9.34 0.46 1.46e-18 Systolic blood pressure; CRC cis rs11997175 0.583 rs34540455 chr8:33799300 C/T ch.8.33884649F chr8:33765107 NA 0.43 5.93 0.31 7.78e-9 Body mass index; CRC cis rs7737355 0.812 rs11746227 chr5:130961236 C/T cg25547332 chr5:131281432 NA 0.37 5.74 0.3 2.21e-8 Life satisfaction; CRC cis rs10504229 1.000 rs67039591 chr8:58174553 T/A cg01721255 chr8:58191610 C8orf71 0.49 6.17 0.32 2e-9 Developmental language disorder (linguistic errors); CRC cis rs6951245 1.000 rs78861357 chr7:1095418 C/T cg21664854 chr7:1097933 C7orf50;GPR146 0.78 8.81 0.44 7.57e-17 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs6582630 0.519 rs4002440 chr12:38485012 A/G cg26384229 chr12:38710491 ALG10B 0.72 10.11 0.49 4.19e-21 Drug-induced liver injury (flucloxacillin); CRC cis rs9814567 1.000 rs9835204 chr3:134261342 G/T cg06541857 chr3:134203789 ANAPC13;CEP63 -0.4 -6.12 -0.32 2.65e-9 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs17253792 0.822 rs13379343 chr14:56050205 G/A cg01858014 chr14:56050164 KTN1 -0.92 -8.25 -0.41 3.95e-15 Putamen volume; CRC cis rs13118159 0.550 rs4974611 chr4:1358449 T/C cg16405210 chr4:1374714 KIAA1530 -0.92 -14.26 -0.62 2.89e-36 Longevity; CRC cis rs1008375 0.966 rs6833808 chr4:17652526 T/A cg04450456 chr4:17643702 FAM184B 0.37 5.88 0.31 9.91e-9 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs7615952 0.641 rs12491577 chr3:125731131 C/T cg15145296 chr3:125709740 NA -0.59 -6.97 -0.36 1.72e-11 Blood pressure (smoking interaction); CRC cis rs2050392 0.517 rs160017 chr10:30772894 A/G cg25182066 chr10:30743637 MAP3K8 -0.55 -7.49 -0.38 6.37e-13 Inflammatory bowel disease; CRC cis rs3008870 1.000 rs2065001 chr1:67486509 C/G cg08660285 chr1:67390436 MIER1;WDR78 1.04 14.93 0.64 7.31e-39 Lymphocyte percentage of white cells; CRC cis rs11105298 0.891 rs10777162 chr12:89830523 A/G cg08166232 chr12:89918718 WDR51B;GALNT4 -0.58 -7.43 -0.38 9.24e-13 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; CRC cis rs77861329 0.748 rs12629791 chr3:52175783 C/T cg08692210 chr3:52188851 WDR51A 0.5 5.89 0.31 9.43e-9 Macrophage inflammatory protein 1b levels; CRC cis rs6586163 1.000 rs6586164 chr10:90752031 T/A cg03111039 chr10:90751583 FAS;ACTA2 -0.51 -7.45 -0.38 8.36e-13 Chronic lymphocytic leukemia; CRC cis rs61008539 0.853 rs10950611 chr7:861094 G/T cg07138768 chr7:917805 C7orf20 0.3 5.72 0.3 2.45e-8 Perceived unattractiveness to mosquitoes; CRC cis rs7914558 1.000 rs7094843 chr10:104806654 A/C cg04362960 chr10:104952993 NT5C2 0.6 9.07 0.45 1.14e-17 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs13108904 0.870 rs4974577 chr4:1266046 G/A cg00684032 chr4:1343700 KIAA1530 0.48 7.1 0.36 7.89e-12 Obesity-related traits; CRC trans rs12554020 0.581 rs4255201 chr9:96163337 G/A cg23291280 chr19:31847970 NA -0.7 -6.31 -0.33 9.14e-10 Schizophrenia; CRC cis rs73206853 0.702 rs7960516 chr12:110529238 T/A cg12870014 chr12:110450643 ANKRD13A 0.64 8.17 0.41 6.67e-15 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC cis rs1003719 0.788 rs2835576 chr21:38457393 C/T cg10648535 chr21:38446584 PIGP;TTC3 0.51 7.26 0.37 2.74e-12 Eye color traits; CRC cis rs6764363 0.527 rs13091420 chr3:277889 A/G cg02057681 chr3:285234 CHL1 0.4 6.69 0.35 9.83e-11 Sudden cardiac arrest; CRC cis rs2580764 0.598 rs6726158 chr2:55239202 G/T cg09592903 chr2:55203963 RTN4 -0.65 -10.49 -0.5 2.08e-22 Mean platelet volume; CRC cis rs4820539 1.000 rs916583 chr22:23469267 C/T cg14186256 chr22:23484241 RTDR1 0.9 17.57 0.7 3.18e-49 Bone mineral density; CRC cis rs780096 0.526 rs72819536 chr2:27682850 G/T cg17158414 chr2:27665306 KRTCAP3 -0.29 -6.18 -0.32 1.9e-9 Total body bone mineral density; CRC cis rs713587 0.563 rs7591460 chr2:25103967 A/C cg22495460 chr2:25135724 ADCY3 -0.86 -16.44 -0.67 9.68e-45 Body mass index in non-asthmatics; CRC cis rs875971 0.545 rs6961853 chr7:66002022 G/A cg18876405 chr7:65276391 NA 0.44 6.21 0.32 1.58e-9 Aortic root size; CRC cis rs546131 0.928 rs546521 chr11:34824773 G/C cg11058730 chr11:34937778 PDHX;APIP 0.45 6.43 0.33 4.51e-10 Lung disease severity in cystic fibrosis; CRC cis rs73200209 0.704 rs17498131 chr12:116436185 C/G cg01776926 chr12:116560359 MED13L -0.63 -7.54 -0.38 4.5e-13 Total body bone mineral density; CRC cis rs2652834 1.000 rs2729830 chr15:63395812 G/C cg05507819 chr15:63340323 TPM1 0.47 6.24 0.33 1.32e-9 HDL cholesterol; CRC cis rs728616 0.867 rs61860044 chr10:81946538 C/G cg05935833 chr10:81318306 SFTPA2 -0.75 -8.25 -0.41 3.97e-15 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs10479542 0.784 rs6601050 chr5:178986261 C/G cg05457628 chr5:178986728 RUFY1 -0.42 -7.2 -0.37 4.12e-12 Lung cancer; CRC cis rs7811142 1.000 rs11761725 chr7:100039815 C/T cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.73 9.54 0.47 3.46e-19 Platelet count; CRC cis rs7584330 0.704 rs7598954 chr2:238364776 C/T cg11271282 chr2:238384023 NA 0.48 5.6 0.3 4.45e-8 Prostate cancer; CRC cis rs10206020 0.759 rs11903889 chr2:1576601 C/T cg12573674 chr2:1569213 NA -0.78 -10.53 -0.5 1.54e-22 IgG glycosylation; CRC cis rs11148252 0.774 rs7993748 chr13:52941631 C/T cg00495681 chr13:53174319 NA 0.62 9.84 0.48 3.32e-20 Lewy body disease; CRC cis rs11212617 0.935 rs652541 chr11:108226025 C/T cg01991180 chr11:108092276 ATM;NPAT -0.42 -6.12 -0.32 2.61e-9 Response to metformin in type 2 diabetes (glycemic); CRC trans rs61931739 0.500 rs12829125 chr12:34314789 A/G cg26384229 chr12:38710491 ALG10B 0.55 7.05 0.36 1.08e-11 Morning vs. evening chronotype; CRC cis rs853679 0.517 rs9393884 chr6:28046789 A/G cg21251018 chr6:28226885 NKAPL 0.47 6.28 0.33 1.05e-9 Depression; CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg09529537 chr5:78531947 JMY -0.55 -6.7 -0.35 8.8e-11 Diisocyanate-induced asthma; CRC cis rs7772486 0.597 rs6570732 chr6:146245151 G/A cg13319975 chr6:146136371 FBXO30 0.63 9.25 0.45 2.93e-18 Lobe attachment (rater-scored or self-reported); CRC cis rs10779751 0.734 rs910660 chr1:11130643 C/T cg08854313 chr1:11322531 MTOR -0.7 -10.1 -0.49 4.41e-21 Body mass index; CRC cis rs2742417 1.000 rs2673065 chr3:45771222 C/T cg04837898 chr3:45731254 SACM1L -0.34 -5.63 -0.3 3.86e-8 Response to anti-depressant treatment in major depressive disorder; CRC cis rs3096299 0.728 rs1011749 chr16:89510869 G/C cg02187348 chr16:89574699 SPG7 0.39 5.67 0.3 3.05e-8 Multiple myeloma (IgH translocation); CRC cis rs12431939 1.000 rs12431939 chr14:51692699 A/G cg23942311 chr14:51606299 NA 0.54 6.44 0.33 4.32e-10 Cancer; CRC cis rs9733 0.526 rs11204696 chr1:150658721 T/C cg15448220 chr1:150897856 SETDB1 0.47 6.77 0.35 6.05e-11 Tonsillectomy; CRC cis rs3091242 0.804 rs631133 chr1:25724146 T/C cg27572855 chr1:25598939 RHD 0.36 6.14 0.32 2.34e-9 Erythrocyte sedimentation rate; CRC cis rs17433780 0.897 rs17434151 chr1:89500526 G/T cg09516651 chr1:89888402 LOC400759 0.48 7.35 0.38 1.57e-12 Carotid intima media thickness; CRC cis rs1862618 0.573 rs1550821 chr5:56242323 C/T cg24531977 chr5:56204891 C5orf35 0.96 14.14 0.61 8.27e-36 Initial pursuit acceleration; CRC cis rs2032447 0.672 rs9379811 chr6:25955197 G/C cg03517284 chr6:25882590 NA -0.53 -7.51 -0.38 5.66e-13 Intelligence (multi-trait analysis); CRC cis rs7927771 0.864 rs2053979 chr11:47439444 A/G cg05585544 chr11:47624801 NA -0.52 -9.45 -0.46 6.66e-19 Subjective well-being; CRC cis rs9928842 0.823 rs4888365 chr16:75282247 A/G cg08657710 chr16:75258780 CTRB1 -0.57 -6.58 -0.34 1.91e-10 Alcoholic chronic pancreatitis; CRC cis rs896854 0.625 rs4735336 chr8:95973410 A/C cg16049864 chr8:95962084 TP53INP1 0.64 11.77 0.54 6.11e-27 Type 2 diabetes; CRC cis rs7412746 0.611 rs4970985 chr1:150887442 C/T cg10589385 chr1:150898437 SETDB1 -0.27 -5.71 -0.3 2.57e-8 Melanoma; CRC cis rs12602172 1 rs12602172 chr17:38163567 G/A cg17344932 chr17:38183730 MED24;SNORD124 -0.45 -6.98 -0.36 1.62e-11 Neutrophil percentage of white cells;Granulocyte percentage of myeloid white cells; CRC cis rs1401999 0.966 rs2313216 chr3:183637251 C/T cg20387954 chr3:183756860 HTR3D 0.37 6.17 0.32 1.96e-9 Anterior chamber depth; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg13010990 chr3:122103261 FAM162A;CCDC58 0.43 6.02 0.31 4.61e-9 Response to antipsychotic treatment; CRC cis rs4664308 1.000 rs1511218 chr2:160906390 T/C cg03641300 chr2:160917029 PLA2R1 -0.76 -12.77 -0.58 1.35e-30 Idiopathic membranous nephropathy; CRC cis rs7246657 0.943 rs10414904 chr19:37830088 G/A cg23950597 chr19:37808831 NA -0.47 -5.77 -0.3 1.86e-8 Coronary artery calcification; CRC cis rs13217239 0.646 rs10946897 chr6:26995251 A/C cg05192639 chr6:26864778 GUSBL1 0.32 6.08 0.32 3.41e-9 Schizophrenia; CRC cis rs995000 0.868 rs6666816 chr1:63171199 C/T cg19896129 chr1:63156450 NA -0.44 -6.79 -0.35 5.09e-11 Triglyceride levels; CRC cis rs2228479 0.850 rs17226973 chr16:89825248 T/C cg19635926 chr16:89946313 TCF25 0.63 5.68 0.3 3.01e-8 Skin colour saturation; CRC cis rs6545883 0.895 rs7588814 chr2:61695589 A/T cg15711740 chr2:61764176 XPO1 -0.43 -5.67 -0.3 3.16e-8 Tuberculosis; CRC cis rs11614062 0.761 rs11107115 chr12:93972987 A/G cg18151635 chr12:93972918 NA -0.8 -11.54 -0.54 4.1e-26 Height; CRC cis rs4728142 0.584 rs6965542 chr7:128655918 C/T cg06630958 chr7:128577819 IRF5 -0.35 -5.78 -0.3 1.74e-8 Inflammatory bowel disease;Systemic lupus erythematosus;Ulcerative colitis; CRC cis rs3736485 0.932 rs4775946 chr15:51775930 A/G cg08986416 chr15:51914746 DMXL2 -0.45 -6.43 -0.33 4.41e-10 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs924607 0.900 rs1697950 chr5:616890 G/A cg04476341 chr5:669733 TPPP -0.42 -6.94 -0.36 2.09e-11 Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia; CRC cis rs9910055 0.639 rs7217858 chr17:42254527 T/G cg19774624 chr17:42201019 HDAC5 -0.73 -11.74 -0.54 7.86e-27 Total body bone mineral density; CRC cis rs300703 0.654 rs393277 chr2:121539 G/T cg21211680 chr2:198530 NA -0.99 -11.71 -0.54 1.01e-26 Blood protein levels; CRC cis rs2239547 0.603 rs59989280 chr3:53098875 T/C cg11645453 chr3:52864694 ITIH4 0.53 8.82 0.44 6.94e-17 Schizophrenia; CRC cis rs9326248 0.590 rs2542063 chr11:116684767 C/T cg26566898 chr11:117069891 TAGLN 0.27 5.85 0.31 1.19e-8 Blood protein levels; CRC cis rs1570884 0.516 rs9316463 chr13:50176844 G/A cg02321871 chr13:50159138 RCBTB1 -0.45 -6.32 -0.33 8.5e-10 Sum basophil neutrophil counts;Sum neutrophil eosinophil counts;Neutrophil count;Myeloid white cell count;Granulocyte count; CRC trans rs877282 0.898 rs11253346 chr10:765313 A/G cg22713356 chr15:30763199 NA 1.3 15.02 0.64 3.32e-39 Uric acid levels; CRC cis rs2637266 0.549 rs4633402 chr10:78414244 C/A cg18941641 chr10:78392320 NA -0.36 -6.05 -0.32 4.04e-9 Pulmonary function; CRC cis rs977987 0.806 rs11640473 chr16:75403289 C/A cg03315344 chr16:75512273 CHST6 0.54 9.11 0.45 8.36e-18 Dupuytren's disease; CRC cis rs951366 0.617 rs823080 chr1:205789282 G/A cg11965913 chr1:205819406 PM20D1 1.03 20.06 0.74 5.16e-59 Menarche (age at onset); CRC cis rs2298450 0.717 rs9974041 chr21:37634873 G/A cg02919814 chr21:37666008 DOPEY2 -0.5 -6.65 -0.34 1.23e-10 Schizophrenia; CRC cis rs881375 0.902 rs2900180 chr9:123706382 T/C cg09419670 chr9:123605666 PSMD5;LOC253039 0.56 8.33 0.42 2.21e-15 Rheumatoid arthritis; CRC cis rs910187 0.597 rs1883885 chr20:45795456 T/C cg27589058 chr20:45804311 EYA2 -0.34 -6.39 -0.33 5.75e-10 Migraine; CRC cis rs2160860 0.773 rs11787388 chr8:39799193 G/T cg11363097 chr8:39792086 IDO2 -0.42 -7.39 -0.38 1.22e-12 Blood metabolite levels; CRC cis rs7762018 0.891 rs73242950 chr6:170144737 C/T cg19338460 chr6:170058176 WDR27 -0.69 -7.6 -0.39 3.03e-13 Thiazide-induced adverse metabolic effects in hypertensive patients; CRC cis rs10463316 0.817 rs1810083 chr5:150776807 A/G cg03212797 chr5:150827313 SLC36A1 0.46 7.11 0.36 7.21e-12 Metabolite levels (Pyroglutamine); CRC cis rs977987 0.843 rs4888415 chr16:75448921 C/T cg03315344 chr16:75512273 CHST6 0.51 8.69 0.43 1.75e-16 Dupuytren's disease; CRC trans rs459571 0.959 rs461462 chr9:136911272 C/T cg15028160 chr19:49622717 PPFIA3;C19orf73 -0.56 -7.24 -0.37 3.29e-12 Platelet distribution width; CRC cis rs17270561 0.943 rs4478398 chr6:25694684 T/C cg17691542 chr6:26056736 HIST1H1C 0.69 7.69 0.39 1.67e-13 Iron status biomarkers; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg07817097 chr1:179851575 TOR1AIP1 0.44 6.93 0.36 2.25e-11 Liver disease severity in Alagille syndrome; CRC trans rs6951245 0.572 rs79489623 chr7:1045632 C/T cg13565492 chr6:43139072 SRF -0.85 -6.18 -0.32 1.86e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg06651054 chr15:83680015 C15orf40 0.5 6.57 0.34 1.91e-10 Thyroid stimulating hormone; CRC cis rs1572438 0.839 rs6597297 chr6:864484 C/T cg13447295 chr6:887704 NA 0.44 6.69 0.35 9.7e-11 Aging; CRC cis rs4332037 0.722 rs28705934 chr7:1916116 T/A cg24505167 chr7:1915268 MAD1L1 -0.49 -7.44 -0.38 8.84e-13 Bipolar disorder; CRC cis rs561341 0.883 rs72821942 chr17:30234460 C/T cg12193833 chr17:30244370 NA -0.68 -8.38 -0.42 1.57e-15 Hip circumference adjusted for BMI; CRC cis rs11148252 0.904 rs9568734 chr13:53004222 G/A cg00495681 chr13:53174319 NA 0.66 10.41 0.5 3.84e-22 Lewy body disease; CRC cis rs7692995 0.920 rs73802707 chr4:17932319 C/T cg08925142 chr4:18023851 LCORL -0.55 -5.95 -0.31 7.03e-9 Height; CRC cis rs1799949 1.000 rs35668327 chr17:41273095 G/A cg05368731 chr17:41323189 NBR1 0.69 10.46 0.5 2.77e-22 Menopause (age at onset); CRC cis rs1904096 0.506 rs4558832 chr4:95148042 G/A cg11021082 chr4:95130006 SMARCAD1 -0.6 -9.57 -0.47 2.69e-19 Type 2 diabetes; CRC cis rs9287719 0.967 rs12692417 chr2:10745718 C/G cg00105475 chr2:10696890 NA 0.45 7.21 0.37 3.91e-12 Prostate cancer; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg26638003 chr17:685505 GLOD4;RNMTL1 0.41 6.0 0.31 5.2e-9 Response to antipsychotic treatment; CRC cis rs1223397 0.938 rs35511719 chr6:13282442 T/C cg00460589 chr6:13274354 PHACTR1 0.49 5.98 0.31 5.74e-9 Blood pressure; CRC trans rs1814175 0.626 rs1722008 chr11:49897676 A/T cg15704280 chr7:45808275 SEPT13 -0.97 -18.76 -0.72 6.72e-54 Height; CRC cis rs1862618 0.853 rs252902 chr5:56116085 A/G cg22800045 chr5:56110881 MAP3K1 0.53 5.96 0.31 6.46e-9 Initial pursuit acceleration; CRC cis rs478304 0.903 rs12293022 chr11:65531698 C/T cg08755490 chr11:65554678 OVOL1 0.42 6.15 0.32 2.24e-9 Acne (severe); CRC cis rs12142240 0.698 rs72677587 chr1:46813982 G/A cg14993813 chr1:46806288 NSUN4 -0.5 -6.42 -0.33 4.75e-10 Menopause (age at onset); CRC trans rs2243480 1.000 rs35046236 chr7:65408613 T/C cg10756647 chr7:56101905 PSPH 0.72 7.98 0.4 2.39e-14 Diabetic kidney disease; CRC cis rs9902453 0.935 rs9905950 chr17:28431198 T/C cg26525008 chr17:28256777 EFCAB5;SSH2 0.72 11.76 0.54 6.77e-27 Coffee consumption (cups per day); CRC cis rs2739330 0.828 rs5760107 chr22:24252597 T/C cg11060661 chr22:24314208 DDT;DDTL 0.49 8.45 0.42 9.34e-16 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs6968419 0.547 rs72603593 chr7:115894376 T/C cg02561103 chr7:115862891 TES -0.43 -6.45 -0.34 3.94e-10 Intraocular pressure; CRC cis rs7927592 0.913 rs7109294 chr11:68332093 A/G cg01657329 chr11:68192670 LRP5 -0.45 -6.45 -0.34 4e-10 Total body bone mineral density; CRC cis rs7705042 0.865 rs6580223 chr5:141489027 G/T cg07392085 chr5:141489673 NDFIP1 0.46 7.25 0.37 3e-12 Asthma; CRC cis rs11155671 0.530 rs9371223 chr6:150214806 T/C cg13206674 chr6:150067644 NUP43 0.52 7.15 0.37 5.81e-12 Testicular germ cell tumor; CRC cis rs9467711 0.651 rs16891334 chr6:26124303 T/C cg08501292 chr6:25962987 TRIM38 0.64 6.15 0.32 2.27e-9 Autism spectrum disorder or schizophrenia; CRC cis rs7781266 0.619 rs4731992 chr7:133702097 A/G cg03336402 chr7:133662267 EXOC4 -0.58 -6.73 -0.35 7.75e-11 Educational attainment (college completion); CRC cis rs9549328 0.564 rs34556022 chr13:113617437 G/A cg24588162 chr13:113633484 MCF2L 0.36 6.52 0.34 2.68e-10 Systolic blood pressure; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg12830829 chr14:51707081 TMX1 0.44 6.91 0.36 2.54e-11 Liver disease severity in Alagille syndrome; CRC cis rs2842992 0.830 rs2758320 chr6:160070676 T/G cg11366901 chr6:160182831 ACAT2 0.86 11.4 0.53 1.3e-25 Age-related macular degeneration (geographic atrophy); CRC cis rs1538970 0.748 rs11211137 chr1:46013892 T/A cg05343316 chr1:45956843 TESK2 0.74 9.54 0.47 3.32e-19 Platelet count; CRC trans rs4621152 1.000 rs11894340 chr2:217917167 A/G cg14039228 chr17:38374778 WIPF2 -0.39 -6.05 -0.32 3.89e-9 Gut microbiota (bacterial taxa); CRC cis rs17023223 0.537 rs7532510 chr1:119594236 A/G cg05756136 chr1:119680316 WARS2 -0.51 -6.79 -0.35 5.35e-11 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for BMI in active individuals; CRC cis rs9322193 0.962 rs4552 chr6:150132319 A/T cg07701084 chr6:150067640 NUP43 0.48 6.7 0.35 9.05e-11 Lung cancer; CRC cis rs8067545 0.611 rs8078716 chr17:20044291 G/A cg13482628 chr17:19912719 NA 0.43 6.77 0.35 5.78e-11 Schizophrenia; CRC cis rs11958404 0.932 rs76601259 chr5:157430337 C/T cg05962755 chr5:157440814 NA 1.02 12.62 0.57 4.6e-30 IgG glycosylation; CRC cis rs7113874 0.589 rs7939731 chr11:8510299 T/G cg17679104 chr11:8615758 STK33 -0.36 -5.92 -0.31 8.19e-9 Body mass index in physically active individuals;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs8067354 0.645 rs2645487 chr17:57886125 T/G cg13753209 chr17:57696993 CLTC 0.45 5.88 0.31 9.94e-9 Hemoglobin concentration; CRC cis rs853679 0.882 rs9393908 chr6:28190830 T/A cg03623178 chr6:28175578 NA 0.9 7.35 0.38 1.55e-12 Depression; CRC cis rs875971 1.000 rs6946143 chr7:65579722 A/C cg11764359 chr7:65958608 NA 0.56 9.17 0.45 5.41e-18 Aortic root size; CRC cis rs4319547 0.774 rs7959238 chr12:123131498 A/T cg23029597 chr12:123009494 RSRC2 -0.52 -6.95 -0.36 1.99e-11 Body mass index; CRC trans rs1728785 1.000 rs889561 chr16:68605741 G/A cg04657470 chr2:198365150 HSPE1;HSPD1 0.75 8.94 0.44 2.86e-17 Ulcerative colitis; CRC cis rs7932354 0.528 rs7125807 chr11:47041163 G/T cg19486271 chr11:47235900 DDB2 0.42 6.19 0.32 1.79e-9 Bone mineral density (hip);Bone mineral density; CRC cis rs9322193 0.962 rs12175575 chr6:150084487 G/A cg07701084 chr6:150067640 NUP43 0.46 6.49 0.34 3.1e-10 Lung cancer; CRC cis rs72627123 1.000 rs72627117 chr14:74355233 T/C cg19860245 chr14:74300557 NA -0.51 -5.63 -0.3 3.81e-8 Morning vs. evening chronotype; CRC cis rs6502050 0.731 rs9892653 chr17:80100191 G/T cg09264619 chr17:80180166 NA -0.34 -5.81 -0.3 1.5e-8 Life satisfaction; CRC cis rs4713118 0.955 rs9368528 chr6:27683798 G/A cg12273811 chr6:28175739 NA 0.51 6.99 0.36 1.49e-11 Parkinson's disease; CRC cis rs477895 0.653 rs3824854 chr11:63885305 C/T cg23719950 chr11:63933701 MACROD1 -0.64 -8.12 -0.41 9.37e-15 Mean platelet volume; CRC cis rs1153858 1.000 rs4534782 chr15:45652933 G/A cg21132104 chr15:45694354 SPATA5L1 0.6 8.87 0.44 4.74e-17 Homoarginine levels; CRC cis rs78456975 1.000 rs10208340 chr2:1563100 G/A cg12573674 chr2:1569213 NA -0.74 -7.7 -0.39 1.59e-13 Placebo response in major depressive disorder (% change in symptom score); CRC cis rs9467711 0.591 rs7748167 chr6:25904652 A/C cg08501292 chr6:25962987 TRIM38 0.94 9.22 0.45 3.55e-18 Autism spectrum disorder or schizophrenia; CRC cis rs11098499 0.954 rs12505469 chr4:120249585 C/T cg24375607 chr4:120327624 NA 0.48 7.33 0.37 1.84e-12 Corneal astigmatism; CRC cis rs11123610 0.520 rs12711962 chr2:3717985 C/T cg25251562 chr2:3704773 ALLC -0.47 -5.94 -0.31 7.09e-9 Response to inhaled corticosteroid treatment in asthma (change in FEV1); CRC trans rs10875746 0.859 rs11558768 chr12:48577789 C/T cg16281234 chr15:35388805 NA -0.5 -6.3 -0.33 9.68e-10 Longevity (90 years and older); CRC trans rs10504229 1.000 rs58382845 chr8:58169851 A/C cg04077850 chr5:125800366 GRAMD3 0.37 6.18 0.32 1.91e-9 Developmental language disorder (linguistic errors); CRC cis rs62344088 0.590 rs60845955 chr5:185094 C/T cg22857025 chr5:266934 NA -0.91 -7.92 -0.4 3.57e-14 Asthma (childhood onset); CRC cis rs231513 1.000 rs231526 chr17:41951277 T/C cg26893861 chr17:41843967 DUSP3 -0.82 -7.36 -0.38 1.52e-12 Cognitive function; CRC cis rs7662987 0.540 rs2851278 chr4:100021253 G/C cg13256891 chr4:100009986 ADH5 0.62 8.39 0.42 1.5e-15 Smoking initiation; CRC cis rs12477438 0.520 rs2516829 chr2:99773201 T/G cg26064155 chr2:99771622 LIPT1;TSGA10 0.82 14.39 0.62 8.96e-37 Chronic sinus infection; CRC cis rs344364 0.511 rs1742467 chr16:1950187 G/T cg00046913 chr16:1877150 HAGH;FAHD1 -0.58 -6.06 -0.32 3.66e-9 Glomerular filtration rate in chronic kidney disease; CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg24088775 chr19:12595630 ZNF709 0.38 6.2 0.32 1.7e-9 Obesity-related traits; CRC cis rs243505 0.559 rs1558420 chr7:148480114 G/T cg09806900 chr7:148480153 CUL1 0.6 8.4 0.42 1.36e-15 Inflammatory bowel disease;Crohn's disease; CRC cis rs7927592 0.956 rs11228251 chr11:68244558 G/T cg16797656 chr11:68205561 LRP5 0.41 7.01 0.36 1.39e-11 Total body bone mineral density; CRC cis rs4242434 0.927 rs11781149 chr8:22473158 C/T cg03733263 chr8:22462867 KIAA1967 1.04 18.13 0.71 2.1e-51 Exploratory eye movement dysfunction in schizophrenia (cognitive search score); CRC cis rs6952808 0.609 rs12699449 chr7:1951227 G/C cg14004847 chr7:1930337 MAD1L1 -0.4 -5.89 -0.31 9.61e-9 Bipolar disorder and schizophrenia; CRC cis rs236352 0.576 rs2116447 chr6:36837364 T/C cg10099585 chr6:36853529 C6orf89 -0.45 -6.3 -0.33 9.3e-10 Heart rate; CRC cis rs2290159 0.752 rs3773352 chr3:12651982 G/C cg23032965 chr3:12705835 RAF1 0.49 6.31 0.33 9.24e-10 Cholesterol, total; CRC cis rs950169 0.800 rs34302901 chr15:85110943 C/G cg03959625 chr15:84868606 LOC388152 0.37 5.68 0.3 2.89e-8 Schizophrenia; CRC cis rs2204008 0.665 rs11179830 chr12:38220966 T/C cg13010199 chr12:38710504 ALG10B 0.44 5.84 0.31 1.28e-8 Bladder cancer; CRC cis rs7666738 0.791 rs10010438 chr4:99022177 C/T cg05340658 chr4:99064831 C4orf37 0.61 9.51 0.46 4.05e-19 Colonoscopy-negative controls vs population controls; CRC trans rs2727020 0.729 rs4315497 chr11:49214499 G/A cg11707556 chr5:10655725 ANKRD33B 0.36 6.58 0.34 1.81e-10 Coronary artery disease; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg17115147 chr6:45345601 RUNX2;SUPT3H -0.42 -6.48 -0.34 3.37e-10 Myopia (pathological); CRC cis rs734999 0.505 rs60687045 chr1:2539603 G/A cg20673091 chr1:2541236 MMEL1 0.36 5.79 0.3 1.69e-8 Ulcerative colitis; CRC cis rs2243480 1.000 rs387676 chr7:65598220 C/T cg18252515 chr7:66147081 NA -1.24 -14.68 -0.63 7.09e-38 Diabetic kidney disease; CRC cis rs7829975 0.564 rs2921060 chr8:8317817 G/T cg08975724 chr8:8085496 FLJ10661 -0.55 -7.81 -0.4 7.68e-14 Mood instability; CRC cis rs9291683 0.546 rs13139055 chr4:10038924 G/T cg11266682 chr4:10021025 SLC2A9 0.52 10.64 0.51 6.61e-23 Bone mineral density; CRC cis rs9488822 0.676 rs11153594 chr6:116354591 A/G cg05304507 chr6:116381966 FRK -0.32 -8.95 -0.44 2.63e-17 Cholesterol, total;LDL cholesterol; CRC cis rs7725052 0.609 rs13358164 chr5:40455962 G/A cg09067459 chr5:40385259 NA -0.4 -6.57 -0.34 1.94e-10 Pediatric autoimmune diseases; CRC cis rs7662987 0.517 rs3018048 chr4:100005538 C/T cg12011299 chr4:100065546 ADH4 0.49 9.21 0.45 4.05e-18 Smoking initiation; CRC cis rs12541335 0.639 rs13257108 chr8:22165043 T/C cg26039829 chr8:22132926 PIWIL2 0.5 8.93 0.44 3.17e-17 Hypertriglyceridemia; CRC cis rs9868809 0.656 rs13324119 chr3:48710606 G/C cg07636037 chr3:49044803 WDR6 -0.64 -6.13 -0.32 2.5e-9 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; CRC cis rs748404 0.660 rs2439846 chr15:43740970 G/A cg02155558 chr15:43621948 ADAL;LCMT2 0.51 7.47 0.38 7.15e-13 Lung cancer; CRC cis rs2153535 0.542 rs915354 chr6:8440357 T/C cg21535247 chr6:8435926 SLC35B3 0.47 7.12 0.37 6.79e-12 Motion sickness; CRC cis rs10504229 0.683 rs72650849 chr8:58140323 A/G cg21724239 chr8:58056113 NA 0.49 6.81 0.35 4.75e-11 Developmental language disorder (linguistic errors); CRC trans rs3780486 0.801 rs3780495 chr9:33125942 A/C cg20290983 chr6:43655470 MRPS18A 1.16 26.67 0.83 3.01e-84 IgG glycosylation; CRC cis rs1153858 1.000 rs2066090 chr15:45650018 T/C cg10760299 chr15:45669010 GATM 0.49 7.84 0.4 6.41e-14 Homoarginine levels; CRC trans rs116095464 0.558 rs56081398 chr5:247318 C/T cg00938859 chr5:1591904 SDHAP3 0.66 6.07 0.32 3.52e-9 Breast cancer; CRC cis rs12701220 0.948 rs10275712 chr7:1082918 G/A cg26240231 chr7:1148101 C7orf50 -0.47 -6.48 -0.34 3.44e-10 Bronchopulmonary dysplasia; CRC cis rs3812762 0.833 rs10500705 chr11:8805261 A/G cg21881798 chr11:8931708 C11orf17;ST5 -0.42 -6.18 -0.32 1.87e-9 Hypospadias; CRC cis rs910187 0.605 rs6018320 chr20:45804412 A/G cg27589058 chr20:45804311 EYA2 -0.41 -7.95 -0.4 2.95e-14 Migraine; CRC cis rs7927592 0.913 rs7123564 chr11:68362164 C/T cg01657329 chr11:68192670 LRP5 -0.48 -6.83 -0.35 4.09e-11 Total body bone mineral density; CRC cis rs2204008 0.837 rs7308714 chr12:38274307 T/C cg13010199 chr12:38710504 ALG10B 0.44 5.73 0.3 2.33e-8 Bladder cancer; CRC cis rs2354432 0.556 rs59180647 chr1:146772062 C/T cg25205988 chr1:146714368 CHD1L -1.13 -9.44 -0.46 7.14e-19 Mitochondrial DNA levels; CRC cis rs7849270 0.760 rs419636 chr9:131931277 T/C cg13538475 chr9:131942899 NA 0.31 5.85 0.31 1.19e-8 Blood metabolite ratios; CRC cis rs9326248 0.817 rs6589598 chr11:117002403 A/G cg11861562 chr11:117069780 TAGLN 0.4 7.92 0.4 3.63e-14 Blood protein levels; CRC cis rs7772486 0.686 rs1569540 chr6:146069112 A/G cg23711669 chr6:146136114 FBXO30 -0.67 -11.06 -0.52 2.19e-24 Lobe attachment (rater-scored or self-reported); CRC cis rs9768139 0.935 rs7782393 chr7:158120486 G/A cg25566285 chr7:158114605 PTPRN2 -0.59 -10.11 -0.49 4.04e-21 Calcium levels; CRC cis rs2290405 0.527 rs7663192 chr4:923947 T/C cg03286735 chr4:906491 GAK -0.28 -6.01 -0.31 4.83e-9 Systemic sclerosis; CRC cis rs2032447 0.714 rs2051540 chr6:25947197 T/C cg26028573 chr6:26043587 HIST1H2BB 0.43 6.16 0.32 2.11e-9 Intelligence (multi-trait analysis); CRC cis rs7647973 0.600 rs13064780 chr3:49274826 T/G cg03060546 chr3:49711283 APEH 0.49 7.16 0.37 5.31e-12 Menarche (age at onset); CRC cis rs9394438 0.628 rs10947680 chr6:37543668 T/C cg00985040 chr6:37553208 NA -0.38 -6.22 -0.32 1.52e-9 IgG glycosylation; CRC cis rs10504229 0.683 rs7460059 chr8:58111561 C/T cg02725872 chr8:58115012 NA -0.66 -11.64 -0.54 1.83e-26 Developmental language disorder (linguistic errors); CRC cis rs728616 0.681 rs12769764 chr10:81917113 C/G cg11900509 chr10:81946545 ANXA11 -0.46 -6.81 -0.35 4.79e-11 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs7811142 1.000 rs67040465 chr7:100083078 G/A cg00814883 chr7:100076585 TSC22D4 -0.79 -9.92 -0.48 1.86e-20 Platelet count; CRC cis rs9486719 1.000 rs4077932 chr6:96905144 C/T cg06623918 chr6:96969491 KIAA0776 -0.8 -9.28 -0.46 2.39e-18 Migraine;Coronary artery disease; CRC cis rs2011503 1.000 rs77254326 chr19:19626781 T/G cg11584989 chr19:19387371 SF4 0.58 6.39 0.33 5.66e-10 Bipolar disorder; CRC cis rs9303401 0.573 rs34717648 chr17:56886624 T/A cg10487724 chr17:56770010 TEX14;RAD51C 0.76 9.57 0.47 2.67e-19 Cognitive test performance; CRC cis rs7647973 0.925 rs7429661 chr3:49228800 G/A cg07636037 chr3:49044803 WDR6 0.57 6.71 0.35 8.37e-11 Menarche (age at onset); CRC cis rs7811142 1.000 rs2897358 chr7:100088640 C/G cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.17 17.16 0.69 1.43e-47 Platelet count; CRC trans rs9409565 0.821 rs9299419 chr9:97066584 C/T cg05679027 chr9:99775184 HIATL2 0.4 6.11 0.32 2.77e-9 Colorectal cancer (alcohol consumption interaction); CRC cis rs6963495 0.818 rs73192113 chr7:105169603 C/T cg02135003 chr7:105160482 PUS7 -0.92 -12.46 -0.57 1.94e-29 Bipolar disorder (body mass index interaction); CRC cis rs12474201 0.928 rs35825831 chr2:46932544 T/G cg06386533 chr2:46925753 SOCS5 0.8 13.22 0.59 2.66e-32 Height; CRC cis rs12497850 1.000 rs4858831 chr3:48735558 C/T cg20833759 chr3:49053208 WDR6;DALRD3 0.44 7.47 0.38 7.24e-13 Parkinson's disease; CRC cis rs10504229 0.679 rs72649109 chr8:58031274 A/T cg21724239 chr8:58056113 NA 0.75 9.47 0.46 5.59e-19 Developmental language disorder (linguistic errors); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg07352234 chr8:121457652 MTBP;MRPL13 0.44 6.89 0.36 2.92e-11 Liver disease severity in Alagille syndrome; CRC cis rs9486715 0.867 rs4598081 chr6:96975227 A/G cg18709589 chr6:96969512 KIAA0776 0.5 7.47 0.38 7.3e-13 Headache; CRC cis rs780096 0.526 rs2911713 chr2:27640980 G/A cg12648201 chr2:27665141 KRTCAP3 -0.29 -5.76 -0.3 1.88e-8 Total body bone mineral density; CRC cis rs9296095 0.747 rs12206050 chr6:33564296 A/T cg14003231 chr6:33640908 ITPR3 0.66 9.75 0.47 6.62e-20 Platelet count; CRC cis rs2019137 0.936 rs4849169 chr2:113953657 A/C cg12889195 chr2:113992843 PAX8;LOC440839;LOC654433 -0.51 -7.36 -0.38 1.5e-12 Lymphocyte counts; CRC cis rs6582630 0.519 rs12368889 chr12:38315160 G/A cg26384229 chr12:38710491 ALG10B 0.67 9.0 0.44 1.84e-17 Drug-induced liver injury (flucloxacillin); CRC cis rs2066819 1.000 rs79718165 chr12:56644251 C/T cg26714650 chr12:56694279 CS -1.41 -11.64 -0.54 1.88e-26 Psoriasis vulgaris; CRC cis rs514406 0.861 rs7518390 chr1:53233374 A/G cg08859206 chr1:53392774 SCP2 0.44 6.76 0.35 6.34e-11 Monocyte count; CRC cis rs4819052 0.851 rs4819043 chr21:46660078 G/A cg11663144 chr21:46675770 NA -0.8 -13.38 -0.59 6.77e-33 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs780096 0.526 rs75855890 chr2:27625005 G/T cg21248554 chr2:27665150 KRTCAP3 -0.32 -7.24 -0.37 3.28e-12 Total body bone mineral density; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg01538984 chr7:140396422 LOC100134713;NDUFB2 0.52 7.5 0.38 5.8e-13 Response to antipsychotic treatment; CRC cis rs4727027 0.745 rs10952801 chr7:148864757 T/C cg12479418 chr7:148823350 ZNF425;ZNF398 0.42 5.76 0.3 1.91e-8 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC cis rs9649213 0.613 rs6961129 chr7:97975542 T/G cg24562669 chr7:97807699 LMTK2 0.44 7.3 0.37 2.12e-12 Prostate cancer (SNP x SNP interaction); CRC cis rs57994353 0.793 rs35531907 chr9:139327143 C/T cg14119001 chr9:139324193 INPP5E -0.47 -6.72 -0.35 7.96e-11 Eosinophil counts;Cutaneous squamous cell carcinoma; CRC cis rs2252521 0.583 rs1846490 chr7:29080827 G/A cg11728747 chr7:29037910 CPVL -0.48 -6.75 -0.35 6.51e-11 Cognitive performance; CRC cis rs1046896 0.520 rs8074086 chr17:80818460 A/C cg02711726 chr17:80685570 FN3KRP -0.53 -7.14 -0.37 6.07e-12 Glycated hemoglobin levels; CRC cis rs7613875 0.578 rs4688753 chr3:50074773 A/G cg24308560 chr3:49941425 MST1R 0.43 6.82 0.35 4.29e-11 Body mass index; CRC cis rs7772486 0.875 rs1331644 chr6:146398660 T/C cg13319975 chr6:146136371 FBXO30 -0.4 -6.14 -0.32 2.36e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs6426558 0.537 rs6685823 chr1:227270835 A/G cg10327440 chr1:227177885 CDC42BPA 0.44 6.54 0.34 2.42e-10 Neutrophil percentage of white cells; CRC cis rs3859192 0.599 rs2227321 chr17:38171294 G/C cg17467752 chr17:38218738 THRA -0.49 -7.16 -0.37 5.2e-12 White blood cell count; CRC cis rs3540 0.554 rs34650360 chr15:91059017 T/C cg22089800 chr15:90895588 ZNF774 -0.57 -9.43 -0.46 7.51e-19 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; CRC cis rs17270561 0.636 rs9393656 chr6:25722059 A/C cg17691542 chr6:26056736 HIST1H1C 0.64 8.25 0.41 3.82e-15 Iron status biomarkers; CRC cis rs2070677 1.000 rs12263487 chr10:135403585 A/G cg16964102 chr10:135390573 NA 0.52 7.3 0.37 2.14e-12 Gout; CRC cis rs9549328 0.700 rs2185001 chr13:113616369 G/T cg08614441 chr13:113633676 MCF2L -0.47 -8.05 -0.41 1.51e-14 Systolic blood pressure; CRC trans rs656319 0.625 rs4526366 chr8:9890179 C/G cg06636001 chr8:8085503 FLJ10661 -0.51 -7.48 -0.38 7.02e-13 Myopia (pathological); CRC cis rs2073499 1.000 rs77217288 chr3:50393676 G/A cg09545109 chr3:50388910 TUSC4;CYB561D2 0.68 5.87 0.31 1.07e-8 Schizophrenia; CRC cis rs1046896 0.503 rs12947062 chr17:80686370 A/G cg03160526 chr17:80928410 B3GNTL1 -0.49 -7.31 -0.37 2e-12 Glycated hemoglobin levels; CRC cis rs12477438 0.520 rs10865029 chr2:99718298 C/T cg14399236 chr2:99771627 LIPT1;TSGA10 0.82 14.36 0.62 1.21e-36 Chronic sinus infection; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg19071035 chr6:20404090 E2F3 0.47 6.8 0.35 4.91e-11 Intelligence (multi-trait analysis); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg13674316 chr14:55518174 MAPK1IP1L 0.41 6.27 0.33 1.14e-9 Intelligence (multi-trait analysis); CRC trans rs587242 0.911 rs61786490 chr1:96897274 T/G cg10631902 chr5:14652156 NA 0.44 6.84 0.35 3.84e-11 Body mass index (joint analysis main effects and physical activity interaction);Body mass index in physically inactive individuals;Body mass index; CRC cis rs2447097 1.000 rs2447097 chr17:2278064 A/C cg02569219 chr17:2266849 SGSM2 0.38 5.75 0.3 2.03e-8 Autism spectrum disorder; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg17111669 chr20:44718800 NCOA5 0.41 6.15 0.32 2.28e-9 Intelligence (multi-trait analysis); CRC cis rs7264396 0.563 rs1970577 chr20:34336737 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.47 -6.43 -0.33 4.46e-10 Total cholesterol levels; CRC cis rs9311474 0.508 rs1570 chr3:52586682 T/A cg08222913 chr3:52553049 STAB1 -0.34 -6.46 -0.34 3.7e-10 Electroencephalogram traits; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg25481680 chr10:105110878 PCGF6 0.42 6.8 0.35 4.88e-11 Liver disease severity in Alagille syndrome; CRC cis rs881375 0.902 rs2900180 chr9:123706382 T/C cg09586646 chr9:123605570 PSMD5;LOC253039 0.46 6.25 0.33 1.29e-9 Rheumatoid arthritis; CRC cis rs853679 0.517 rs4713148 chr6:28115921 G/A cg25164649 chr6:28176230 NA 0.78 9.66 0.47 1.33e-19 Depression; CRC cis rs9443645 0.901 rs2050660 chr6:79734726 C/T cg09184832 chr6:79620586 NA -0.51 -9.32 -0.46 1.78e-18 Intelligence (multi-trait analysis); CRC cis rs13064411 0.696 rs6438161 chr3:113227637 G/A cg18753928 chr3:113234510 CCDC52 -0.7 -10.74 -0.51 2.89e-23 Response to simvastatin treatment (PCSK9 protein level change); CRC cis rs950027 0.620 rs872192 chr15:45614502 A/G cg21132104 chr15:45694354 SPATA5L1 0.4 5.62 0.3 4.01e-8 Response to fenofibrate (adiponectin levels); CRC trans rs57506017 0.517 rs12666279 chr7:12260552 G/A cg26461140 chr11:72811902 FCHSD2 0.59 6.69 0.35 9.44e-11 Neuroticism; CRC cis rs10256972 0.553 rs4236381 chr7:1165723 A/C cg23978390 chr7:1156363 C7orf50 0.61 8.5 0.42 6.56e-16 Longevity;Endometriosis; CRC cis rs6076065 0.748 rs6137933 chr20:23383103 A/T cg11657817 chr20:23433608 CST11 0.54 9.32 0.46 1.76e-18 Facial morphology (factor 15, philtrum width); CRC cis rs2380220 0.808 rs2613554 chr6:95916782 C/A cg04719120 chr6:96025338 MANEA -0.53 -5.86 -0.31 1.14e-8 Behavioural disinhibition (generation interaction); CRC cis rs9457247 1.000 rs439237 chr6:167391392 A/G cg23791538 chr6:167370224 RNASET2 -0.38 -5.97 -0.31 6.08e-9 Crohn's disease; CRC cis rs7772486 0.754 rs12199362 chr6:146118225 A/G cg23711669 chr6:146136114 FBXO30 0.8 14.03 0.61 2.33e-35 Lobe attachment (rater-scored or self-reported); CRC cis rs34779708 0.931 rs67261877 chr10:35386340 T/A cg03585969 chr10:35415529 CREM 0.67 8.87 0.44 4.78e-17 Inflammatory bowel disease;Crohn's disease; CRC cis rs11785400 1.000 rs7002932 chr8:143738816 C/A cg10596483 chr8:143751796 JRK 0.49 6.85 0.35 3.71e-11 Schizophrenia; CRC cis rs847577 0.609 rs6965016 chr7:97807882 C/A cg21770322 chr7:97807741 LMTK2 0.87 19.62 0.73 2.74e-57 Breast cancer; CRC cis rs875971 0.660 rs13224319 chr7:66007363 A/G cg05627663 chr7:65219948 SNORA22;CCT6P1 0.43 6.44 0.33 4.21e-10 Aortic root size; CRC cis rs7538876 0.935 rs6586542 chr1:17763566 C/G cg01904812 chr1:17746340 RCC2 -0.4 -6.75 -0.35 6.7e-11 Basal cell carcinoma; CRC cis rs2739330 0.760 rs5751761 chr22:24243736 A/G cg23131131 chr22:24373011 LOC391322 0.61 9.24 0.45 3.24e-18 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs344364 0.511 rs1742395 chr16:1955965 G/A cg03013636 chr16:1946785 NA 0.52 6.49 0.34 3.24e-10 Glomerular filtration rate in chronic kidney disease; CRC cis rs9322193 0.962 rs3763163 chr6:150140906 G/T cg13206674 chr6:150067644 NUP43 0.54 7.69 0.39 1.78e-13 Lung cancer; CRC cis rs2032447 0.772 rs199754 chr6:25992309 A/G cg26028573 chr6:26043587 HIST1H2BB 0.52 7.49 0.38 6.58e-13 Intelligence (multi-trait analysis); CRC cis rs9291683 0.527 rs73212848 chr4:10093299 T/C cg00071950 chr4:10020882 SLC2A9 -0.55 -9.27 -0.46 2.46e-18 Bone mineral density; CRC cis rs60154123 0.505 rs77990373 chr1:210041111 T/C cg22029157 chr1:209979665 IRF6 0.61 6.76 0.35 6.47e-11 Coronary artery disease; CRC cis rs2652834 0.851 rs4468558 chr15:63346681 T/C cg05507819 chr15:63340323 TPM1 0.46 6.04 0.32 4.19e-9 HDL cholesterol; CRC cis rs2267708 0.504 rs3903523 chr7:124668032 A/G cg23710748 chr7:124431027 NA -0.38 -6.06 -0.32 3.73e-9 Chronic lymphocytic leukemia; CRC cis rs798554 0.797 rs798488 chr7:2802522 T/C cg19346786 chr7:2764209 NA -0.39 -6.57 -0.34 1.93e-10 Height; CRC cis rs6701037 1.000 rs34493921 chr1:175122759 A/G cg00321850 chr1:175162397 KIAA0040 -0.36 -5.89 -0.31 9.48e-9 Alcohol dependence; CRC cis rs1179624 0.767 rs34160770 chr7:75259242 C/T cg05145297 chr7:75264568 HIP1 0.54 7.32 0.37 1.93e-12 Age-related nuclear cataracts; CRC cis rs16973500 0.808 rs72801786 chr16:71955085 C/T cg00732059 chr16:71740210 PHLPP2 -0.67 -6.9 -0.36 2.7e-11 Response to anti-TNF therapy in rheumatoid arthritis;Attention deficit hyperactivity disorder and conduct disorder; CRC cis rs8058578 1.000 rs2289442 chr16:30739919 A/G cg00531865 chr16:30841666 NA -0.44 -5.94 -0.31 7.24e-9 Multiple myeloma; CRC trans rs61931739 0.517 rs11052977 chr12:34035030 A/C cg26384229 chr12:38710491 ALG10B 0.52 6.48 0.34 3.28e-10 Morning vs. evening chronotype; CRC cis rs868943 0.714 rs13216178 chr6:116392629 T/G cg18764771 chr6:116381957 FRK 0.26 6.24 0.33 1.34e-9 Total cholesterol levels; CRC cis rs853679 1.000 rs1778508 chr6:28229881 C/T cg03623178 chr6:28175578 NA -0.68 -7.24 -0.37 3.23e-12 Depression; CRC cis rs7119 0.717 rs12898656 chr15:77807995 C/T cg10437265 chr15:77819839 NA -0.62 -10.38 -0.5 5.12e-22 Type 2 diabetes; CRC cis rs10905065 0.931 rs11255228 chr10:5837671 T/C cg25171089 chr10:5708825 ASB13 0.41 5.75 0.3 2.04e-8 Menopause (age at onset); CRC cis rs4132509 1.000 rs9782883 chr1:243892532 A/G cg21452805 chr1:244014465 NA 0.47 6.33 0.33 8.23e-10 RR interval (heart rate); CRC cis rs12431939 0.947 rs59298295 chr14:51659047 T/G cg23942311 chr14:51606299 NA -0.57 -6.39 -0.33 5.84e-10 Cancer; CRC cis rs2760061 0.819 rs708120 chr1:228207651 G/C cg02753203 chr1:228287806 NA 0.71 10.94 0.52 5.68e-24 Diastolic blood pressure; CRC cis rs2243480 1.000 rs410128 chr7:65603173 C/T cg12463550 chr7:65579703 CRCP 0.76 6.72 0.35 7.81e-11 Diabetic kidney disease; CRC cis rs1355223 0.583 rs2941057 chr11:34882220 G/A cg11058730 chr11:34937778 PDHX;APIP 0.73 11.95 0.55 1.35e-27 Systemic lupus erythematosus and Systemic sclerosis; CRC cis rs736408 0.527 rs2336147 chr3:52626443 T/C cg18404041 chr3:52824283 ITIH1 -0.29 -5.99 -0.31 5.47e-9 Bipolar disorder; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg00945735 chr7:41982767 NA 0.35 6.34 0.33 7.42e-10 Liver disease severity in Alagille syndrome; CRC cis rs17152411 0.793 rs7085829 chr10:126587142 A/G cg07906193 chr10:126599966 NA 0.57 6.45 0.33 4.08e-10 Height; CRC cis rs9393692 0.620 rs4412193 chr6:26338056 A/G cg00631329 chr6:26305371 NA -0.55 -9.31 -0.46 1.84e-18 Educational attainment; CRC cis rs12824058 0.831 rs4759451 chr12:130812739 G/A cg24838063 chr12:130822603 PIWIL1 0.58 9.76 0.47 6.18e-20 Menopause (age at onset); CRC trans rs9341835 0.772 rs9294196 chr6:64135193 A/G cg13657004 chr13:50234944 EBPL 0.37 6.24 0.33 1.35e-9 Schizophrenia; CRC cis rs6479527 0.806 rs2211362 chr9:96750361 A/T cg14459158 chr9:96720562 NA 0.41 7.52 0.38 5.11e-13 Esophageal adenocarcinoma; CRC cis rs477895 0.629 rs7130030 chr11:63933733 T/G cg05016508 chr11:63871570 FLRT1;MACROD1 0.54 6.93 0.36 2.19e-11 Mean platelet volume; CRC cis rs9325144 0.513 rs7977596 chr12:38649067 C/A cg13010199 chr12:38710504 ALG10B -0.42 -6.12 -0.32 2.7e-9 Morning vs. evening chronotype; CRC cis rs3760982 1.000 rs3760983 chr19:44286660 C/T cg21496419 chr19:44306685 LYPD5 -0.34 -6.34 -0.33 7.49e-10 Breast cancer (estrogen-receptor negative);Breast cancer; CRC cis rs7786808 0.705 rs1377373 chr7:158215549 A/C cg01191920 chr7:158217561 PTPRN2 0.7 12.52 0.57 1.16e-29 Obesity-related traits; CRC cis rs9487051 0.802 rs6568558 chr6:109592701 A/T cg12927641 chr6:109611667 NA -0.36 -6.51 -0.34 2.77e-10 Reticulocyte fraction of red cells; CRC cis rs3101457 0.515 rs4658632 chr1:244516949 G/T cg09033006 chr1:244517177 C1orf100 -0.45 -6.32 -0.33 8.48e-10 Smoking behavior; CRC cis rs2239547 0.657 rs4687554 chr3:52864135 T/C cg18404041 chr3:52824283 ITIH1 -0.41 -7.66 -0.39 2.08e-13 Schizophrenia; CRC cis rs10504229 0.683 rs55868006 chr8:58135703 C/T cg02725872 chr8:58115012 NA -0.64 -11.55 -0.54 3.85e-26 Developmental language disorder (linguistic errors); CRC trans rs2840044 1.000 rs10068 chr17:33901965 C/G cg19694781 chr19:47549865 TMEM160 0.44 6.97 0.36 1.7e-11 Response to radiotherapy in cancer (late toxicity); CRC cis rs2624839 0.679 rs2624835 chr3:50209049 G/A cg05623727 chr3:50126028 RBM5 0.42 6.61 0.34 1.57e-10 Intelligence (multi-trait analysis); CRC cis rs2836754 1.000 rs2836751 chr21:40290959 C/T cg02119577 chr21:40195074 ETS2 -0.35 -6.04 -0.32 4.13e-9 Crohn's disease;Body mass index; CRC cis rs7605827 0.930 rs1019360 chr2:15524741 C/T cg19274914 chr2:15703543 NA 0.39 5.9 0.31 8.92e-9 Educational attainment (years of education); CRC cis rs4363385 0.818 rs454993 chr1:153008992 C/G cg25856811 chr1:152973957 SPRR3 -0.25 -6.99 -0.36 1.51e-11 Inflammatory skin disease; CRC cis rs524281 0.692 rs10896076 chr11:65840668 A/G cg14036092 chr11:66035641 RAB1B -0.47 -6.07 -0.32 3.43e-9 Electroencephalogram traits; CRC cis rs853679 0.542 rs6934769 chr6:28090931 A/G cg12172441 chr6:28176163 NA 0.62 7.4 0.38 1.17e-12 Depression; CRC cis rs9905704 0.647 rs6503888 chr17:57028126 T/C cg12560992 chr17:57184187 TRIM37 0.62 9.44 0.46 7.26e-19 Testicular germ cell tumor; CRC cis rs1008375 1.000 rs28693609 chr4:17645233 C/T cg02297831 chr4:17616191 MED28 0.42 5.6 0.3 4.43e-8 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs10771431 1.000 rs11611670 chr12:9385535 C/T cg08997352 chr12:9597637 DDX12 -0.48 -7.19 -0.37 4.48e-12 Breast size; CRC cis rs7618501 1.000 rs2234391 chr3:49842625 A/G cg24308560 chr3:49941425 MST1R -0.44 -7.04 -0.36 1.12e-11 Intelligence (multi-trait analysis); CRC cis rs11148252 0.538 rs2897976 chr13:52715944 G/A cg00495681 chr13:53174319 NA 0.62 9.4 0.46 9.76e-19 Lewy body disease; CRC cis rs4908768 0.501 rs6577488 chr1:8534529 T/C cg20416874 chr1:8611966 RERE -0.45 -6.42 -0.33 4.68e-10 Neuroticism (multi-trait analysis);Subjective well-being (multi-trait analysis); CRC cis rs7614311 0.636 rs73117059 chr3:63916028 A/G cg22134162 chr3:63841271 THOC7 -0.57 -5.76 -0.3 1.91e-8 Lung function (FVC);Lung function (FEV1); CRC cis rs7208859 0.673 rs11649765 chr17:29233888 T/A cg13385521 chr17:29058706 SUZ12P 0.69 7.93 0.4 3.48e-14 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs8180040 0.966 rs922957 chr3:47422152 G/C cg10298567 chr3:47292165 KIF9 0.38 6.11 0.32 2.74e-9 Colorectal cancer; CRC trans rs6546324 0.625 rs11900280 chr2:67840401 T/C cg00907274 chr3:27498161 SLC4A7 -0.49 -6.21 -0.32 1.6e-9 Endometriosis; CRC cis rs9925964 0.967 rs12716981 chr16:31118024 C/A cg03418659 chr16:31128414 MYST1 0.52 7.62 0.39 2.67e-13 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg16139199 chr18:19180362 ESCO1 0.43 6.23 0.32 1.43e-9 Response to antipsychotic treatment; CRC cis rs2952156 0.883 rs1495100 chr17:37832279 C/T cg20243544 chr17:37824526 PNMT 0.54 8.74 0.43 1.19e-16 Asthma; CRC cis rs6032067 0.925 rs62208424 chr20:43813341 G/A cg10761708 chr20:43804764 PI3 0.5 5.63 0.3 3.85e-8 Blood protein levels; CRC cis rs4132509 0.739 rs79367267 chr1:243689543 C/A cg21452805 chr1:244014465 NA 0.55 5.84 0.31 1.27e-8 RR interval (heart rate); CRC cis rs2032447 0.670 rs198820 chr6:26124243 G/A cg03264133 chr6:25882463 NA 0.43 5.81 0.31 1.46e-8 Intelligence (multi-trait analysis); CRC trans rs4689592 0.503 rs4689064 chr4:7055603 A/G cg07817883 chr1:32538562 TMEM39B 0.7 7.88 0.4 4.84e-14 Monocyte percentage of white cells; CRC cis rs8077889 0.956 rs4792910 chr17:41840229 T/C cg25876840 chr17:41920477 NA 0.53 7.11 0.36 7.48e-12 Triglycerides; CRC cis rs2346177 0.844 rs4953371 chr2:46651143 T/A cg26688816 chr2:46740690 ATP6V1E2 -0.46 -6.87 -0.35 3.25e-11 HDL cholesterol; CRC trans rs2832077 1.000 rs2832065 chr21:30135362 C/T cg14791747 chr16:20752902 THUMPD1 0.53 6.64 0.34 1.32e-10 Cognitive test performance; CRC cis rs7917772 0.582 rs10786687 chr10:104336994 A/C cg11453585 chr10:104263688 ACTR1A;SUFU 0.82 15.26 0.64 3.8e-40 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC cis rs6598955 0.515 rs61776655 chr1:26541430 T/C cg04990556 chr1:26633338 UBXN11 -0.8 -13.36 -0.59 8.34e-33 Obesity-related traits; CRC cis rs7927592 0.763 rs4340059 chr11:68362433 A/G cg01657329 chr11:68192670 LRP5 -0.56 -9.39 -0.46 1.05e-18 Total body bone mineral density; CRC cis rs28830936 1.000 rs17677991 chr15:42032383 C/G cg17847044 chr15:42102381 MAPKBP1 -0.29 -6.34 -0.33 7.72e-10 Diastolic blood pressure; CRC cis rs3733585 0.605 rs4235355 chr4:10123078 C/A cg11266682 chr4:10021025 SLC2A9 -0.49 -9.07 -0.45 1.06e-17 Cleft plate (environmental tobacco smoke interaction); CRC cis rs6977660 0.507 rs72591450 chr7:19775480 A/G cg07541023 chr7:19748670 TWISTNB 0.79 7.35 0.38 1.56e-12 Thyroid stimulating hormone; CRC cis rs57590327 0.555 rs6795133 chr3:81756267 A/G cg07356753 chr3:81810745 GBE1 -0.65 -8.88 -0.44 4.57e-17 Extraversion; CRC cis rs3204270 0.684 rs57405099 chr17:79637065 T/C cg18367735 chr17:79674897 NA 0.52 5.96 0.31 6.35e-9 Dental caries; CRC cis rs172166 0.561 rs149976 chr6:27987776 C/T cg21251018 chr6:28226885 NKAPL -0.58 -10.1 -0.49 4.6e-21 Cardiac Troponin-T levels; CRC cis rs514406 0.505 rs269289 chr1:53167151 A/C cg24675658 chr1:53192096 ZYG11B -0.7 -10.93 -0.52 6.03e-24 Monocyte count; CRC cis rs208520 1.000 rs208536 chr6:66963440 T/C cg07460842 chr6:66804631 NA -0.92 -11.45 -0.53 8.97e-26 Exhaled nitric oxide output; CRC cis rs2996428 0.667 rs72640928 chr1:3768568 T/C cg22529645 chr1:3704559 LRRC47 0.44 5.89 0.31 9.44e-9 Red cell distribution width; CRC cis rs8180040 0.726 rs6785790 chr3:47146932 C/T cg02527881 chr3:46936655 PTH1R -0.4 -7.43 -0.38 9.38e-13 Colorectal cancer; CRC cis rs6570726 0.791 rs11155432 chr6:145898761 T/C cg13319975 chr6:146136371 FBXO30 -0.42 -6.19 -0.32 1.75e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs3806933 0.522 rs13153937 chr5:110434307 C/T cg04450332 chr5:110408780 TSLP 0.42 5.91 0.31 8.42e-9 Eosinophilic esophagitis; CRC cis rs4713118 0.666 rs2893930 chr6:27738806 T/C cg15845792 chr6:28175446 NA 0.7 7.65 0.39 2.28e-13 Parkinson's disease; CRC cis rs4891159 0.548 rs11150952 chr18:74128188 T/C cg24786174 chr18:74118243 ZNF516 0.9 20.85 0.75 4.04e-62 Longevity; CRC cis rs2404602 0.647 rs11855296 chr15:77092962 C/T cg03037974 chr15:76606532 NA -0.5 -7.06 -0.36 9.85e-12 Blood metabolite levels; CRC cis rs2456568 0.508 rs1607403 chr11:93660514 A/G cg26875233 chr11:93583750 C11orf90 -0.36 -6.91 -0.36 2.46e-11 Response to serotonin reuptake inhibitors in major depressive disorder; CRC trans rs116095464 0.510 rs7723883 chr5:270798 T/C cg00938859 chr5:1591904 SDHAP3 0.67 7.4 0.38 1.17e-12 Breast cancer; CRC cis rs919433 0.927 rs3843857 chr2:198195965 T/C cg03934865 chr2:198174659 NA -0.4 -6.24 -0.33 1.37e-9 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC cis rs35306767 0.714 rs10508206 chr10:1075777 A/C cg20503657 chr10:835505 NA 0.66 8.87 0.44 4.8e-17 Eosinophil percentage of granulocytes; CRC cis rs3785574 0.962 rs62077509 chr17:61848973 A/G cg22520471 chr17:61851767 DDX42;CCDC47 0.45 6.29 0.33 1.02e-9 Height; CRC cis rs4332037 0.950 rs62442895 chr7:1936938 G/A cg25834613 chr7:1915315 MAD1L1 -0.46 -6.5 -0.34 2.95e-10 Bipolar disorder; CRC cis rs67311347 1.000 rs9827461 chr3:40489351 T/A cg24209194 chr3:40518798 ZNF619 0.42 6.06 0.32 3.69e-9 Renal cell carcinoma; CRC cis rs8062405 1.000 rs12444171 chr16:28845251 G/A cg16576597 chr16:28551801 NUPR1 0.48 6.9 0.36 2.65e-11 Cognitive ability (multi-trait analysis);Cognitive ability; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg13373360 chr4:149364881 NR3C2 0.37 6.07 0.32 3.45e-9 Liver disease severity in Alagille syndrome; CRC cis rs11098499 0.738 rs72918577 chr4:120326701 G/A cg09307838 chr4:120376055 NA 0.72 10.94 0.52 5.95e-24 Corneal astigmatism; CRC cis rs11608355 0.618 rs7958220 chr12:109830980 T/C cg19025524 chr12:109796872 NA -0.57 -9.38 -0.46 1.09e-18 Neuroticism; CRC cis rs6831352 0.918 rs29001203 chr4:100053091 A/G cg12011299 chr4:100065546 ADH4 -0.48 -9.08 -0.45 9.94e-18 Alcohol dependence; CRC cis rs2857891 0.909 rs56026267 chr11:6940211 T/C cg26870460 chr11:6947759 ZNF215 0.58 6.05 0.32 3.85e-9 Response to cytadine analogues (cytosine arabinoside); CRC cis rs8078723 0.866 rs3935280 chr17:38189055 A/G cg17344932 chr17:38183730 MED24;SNORD124 0.49 7.69 0.39 1.78e-13 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); CRC cis rs651907 0.535 rs12631513 chr3:101517476 A/C cg11279151 chr3:101281821 RG9MTD1 -0.53 -7.09 -0.36 8.3e-12 Colorectal cancer; CRC cis rs9325144 0.647 rs11168741 chr12:38989120 C/T cg26384229 chr12:38710491 ALG10B -0.52 -7.43 -0.38 9.25e-13 Morning vs. evening chronotype; CRC cis rs7772486 0.686 rs9390349 chr6:146054430 T/G cg13319975 chr6:146136371 FBXO30 0.43 6.51 0.34 2.88e-10 Lobe attachment (rater-scored or self-reported); CRC cis rs12477438 0.871 rs13396584 chr2:99611768 G/T cg14399236 chr2:99771627 LIPT1;TSGA10 0.59 7.12 0.37 6.85e-12 Chronic sinus infection; CRC cis rs7107174 1.000 rs11237460 chr11:78056274 G/A cg12700464 chr11:78128424 GAB2 -0.47 -5.76 -0.3 1.96e-8 Testicular germ cell tumor; CRC cis rs1707322 0.963 rs34907901 chr1:46405214 T/G cg03146154 chr1:46216737 IPP 0.51 7.07 0.36 9.15e-12 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs35995292 0.534 rs917322 chr7:38943165 A/T cg19327137 chr7:38886074 VPS41 -0.65 -11.05 -0.52 2.41e-24 Subjective well-being (multi-trait analysis); CRC cis rs9611565 0.512 rs139562 chr22:42196684 G/C cg06634786 chr22:41940651 POLR3H -0.69 -7.77 -0.39 1.04e-13 Vitiligo; CRC cis rs4713118 0.824 rs742046 chr6:27739254 A/G cg15786705 chr6:28176104 NA 0.53 6.93 0.36 2.17e-11 Parkinson's disease; CRC cis rs6089584 0.586 rs4925216 chr20:60599923 G/A cg23262073 chr20:60523788 NA -0.35 -5.7 -0.3 2.72e-8 Body mass index; CRC cis rs9522267 0.535 rs9515451 chr13:112234382 A/G cg10483660 chr13:112241077 NA -0.48 -8.99 -0.44 2.04e-17 Hepatitis; CRC cis rs561341 0.824 rs1978115 chr17:30220776 A/C cg19193384 chr17:30244184 NA -0.54 -6.44 -0.33 4.33e-10 Hip circumference adjusted for BMI; CRC cis rs172166 0.694 rs2791332 chr6:28108788 C/T cg21251018 chr6:28226885 NKAPL 0.46 6.93 0.36 2.28e-11 Cardiac Troponin-T levels; CRC cis rs6691722 0.503 rs3765428 chr1:24706113 G/A cg18323236 chr1:24743029 NIPAL3 0.38 5.64 0.3 3.66e-8 Response to interferon beta in multiple sclerosis; CRC cis rs8062405 0.755 rs4787456 chr16:28559573 C/T cg16576597 chr16:28551801 NUPR1 0.56 8.26 0.41 3.67e-15 Cognitive ability (multi-trait analysis);Cognitive ability; CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg04533189 chr17:64298763 PRKCA 0.33 6.12 0.32 2.74e-9 Obesity-related traits; CRC cis rs9900062 0.586 rs6504249 chr17:62676149 A/G cg02097616 chr17:62675921 NA 0.47 6.27 0.33 1.13e-9 QT interval; CRC cis rs6062302 0.548 rs6089940 chr20:62252695 C/T cg09650180 chr20:62225654 GMEB2 -0.51 -6.74 -0.35 6.97e-11 Glioblastoma; CRC cis rs11792861 0.781 rs2151426 chr9:111743797 A/C cg05043794 chr9:111880884 C9orf5 -0.34 -5.94 -0.31 7.2e-9 Menarche (age at onset); CRC cis rs9660992 0.573 rs7368327 chr1:205214792 C/T cg03948781 chr1:205179583 DSTYK 0.41 5.61 0.3 4.22e-8 Mean corpuscular volume;Mean platelet volume; CRC cis rs4363385 0.747 rs6678107 chr1:152966818 T/G cg25856811 chr1:152973957 SPRR3 -0.26 -7.17 -0.37 5e-12 Inflammatory skin disease; CRC cis rs3771570 1.000 rs62186411 chr2:242236667 A/C cg21155796 chr2:242212141 HDLBP 0.64 7.0 0.36 1.48e-11 Prostate cancer; CRC cis rs2760061 0.846 rs3094912 chr1:228209815 T/A cg02753203 chr1:228287806 NA 0.68 10.56 0.5 1.17e-22 Diastolic blood pressure; CRC cis rs12188164 0.686 rs56279338 chr5:416118 G/A cg00976097 chr5:421733 AHRR -0.44 -6.02 -0.31 4.69e-9 Cystic fibrosis severity; CRC cis rs56307353 0.513 rs2041120 chr19:1961474 C/T cg26776924 chr19:1969666 CSNK1G2 0.49 7.8 0.4 8.08e-14 Coronary artery disease; CRC cis rs8141797 1.000 rs8138799 chr22:24556902 G/A cg20894457 chr22:24584366 SUSD2 0.63 7.2 0.37 4.05e-12 Amyotrophic lateral sclerosis;Coronary artery disease; CRC cis rs7829975 0.682 rs7013471 chr8:8687325 A/G cg06636001 chr8:8085503 FLJ10661 -0.46 -6.65 -0.34 1.25e-10 Mood instability; CRC cis rs10256972 0.577 rs6962809 chr7:1208889 A/G cg09177884 chr7:1199841 ZFAND2A -0.54 -8.07 -0.41 1.3e-14 Longevity;Endometriosis; CRC cis rs2836974 0.644 rs2836986 chr21:40702136 A/C cg22974920 chr21:40686053 BRWD1 -0.42 -5.65 -0.3 3.5e-8 Cognitive function; CRC cis rs394563 0.967 rs438852 chr6:149794533 C/T cg16235748 chr6:149772707 ZC3H12D 0.36 6.34 0.33 7.53e-10 Dupuytren's disease; CRC cis rs972578 0.806 rs5751386 chr22:43245345 T/C cg01576275 chr22:43409880 NA -0.39 -6.05 -0.32 3.99e-9 Mean platelet volume; CRC cis rs151227923 1 rs151227923 chr7:155106564 C/T cg04811098 chr7:155088454 INSIG1 0.42 6.49 0.34 3.17e-10 Stem cell growth factor beta levels; CRC cis rs9463078 0.585 rs1748235 chr6:45141361 T/C cg25276700 chr6:44698697 NA -0.23 -5.6 -0.3 4.44e-8 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; CRC cis rs1475911 0.708 rs66994219 chr21:43521647 G/A cg19766460 chr21:43528205 UMODL1;C21orf128 0.96 14.22 0.62 4.36e-36 IgG glycosylation; CRC cis rs9894429 0.789 rs9747336 chr17:79584189 C/T cg21984481 chr17:79567631 NPLOC4 -0.58 -11.19 -0.53 7.42e-25 Eye color traits; CRC cis rs1448094 0.512 rs7302741 chr12:86237127 C/T cg19622623 chr12:86230825 RASSF9 -0.41 -6.57 -0.34 1.94e-10 Major depressive disorder; CRC cis rs703842 1.000 rs10877015 chr12:58167788 A/G cg04478727 chr12:58166393 METTL1;FAM119B 0.43 5.77 0.3 1.84e-8 Multiple sclerosis; CRC cis rs2408955 0.568 rs12099462 chr12:48503104 T/C cg15465823 chr12:48382534 COL2A1 -0.38 -6.36 -0.33 6.57e-10 Glycated hemoglobin levels; CRC cis rs8063761 0.589 rs4238833 chr16:90050689 G/T cg05185784 chr16:90016020 DEF8 0.56 8.69 0.43 1.78e-16 Squamous cell carcinoma; CRC cis rs10504229 0.861 rs114700910 chr8:58170642 C/T cg22535103 chr8:58192502 C8orf71 -0.82 -12.22 -0.56 1.44e-28 Developmental language disorder (linguistic errors); CRC cis rs734999 0.588 rs876938 chr1:2523212 G/C cg20673091 chr1:2541236 MMEL1 0.37 5.98 0.31 5.88e-9 Ulcerative colitis; CRC cis rs12922317 0.556 rs11648938 chr16:12094149 C/T cg09319797 chr16:12061715 TNFRSF17 0.32 5.69 0.3 2.78e-8 Schizophrenia; CRC cis rs1448094 0.511 rs17345299 chr12:86166005 C/G cg19622623 chr12:86230825 RASSF9 -0.38 -5.85 -0.31 1.18e-8 Major depressive disorder; CRC cis rs875971 0.571 rs160641 chr7:65577346 G/A cg11764359 chr7:65958608 NA -0.46 -5.81 -0.31 1.47e-8 Aortic root size; CRC cis rs9309473 1.000 rs6705489 chr2:73648811 G/T cg20560298 chr2:73613845 ALMS1 -0.47 -5.88 -0.31 1.02e-8 Metabolite levels; CRC cis rs10752881 1.000 rs10797810 chr1:182980950 C/T ch.1.3577855R chr1:183094577 LAMC1 0.87 15.17 0.64 9.03e-40 Colorectal cancer; CRC cis rs7762018 0.607 rs61740334 chr6:170047902 T/A cg24289452 chr6:170231220 NA -0.93 -7.57 -0.39 3.88e-13 Thiazide-induced adverse metabolic effects in hypertensive patients; CRC cis rs9611565 0.694 rs202631 chr22:41863423 A/G cg03806693 chr22:41940476 POLR3H 1.04 14.75 0.63 3.78e-38 Vitiligo; CRC cis rs12594515 1.000 rs12595137 chr15:45986105 G/T cg22117107 chr15:45993392 NA -0.44 -8.88 -0.44 4.52e-17 Waist circumference;Weight; CRC cis rs939584 1.000 rs12714415 chr2:651430 T/C cg03610516 chr2:642275 NA -0.43 -5.93 -0.31 7.78e-9 Body mass index; CRC cis rs10461617 0.531 rs2662033 chr5:56213410 T/G cg03609598 chr5:56110824 MAP3K1 -0.6 -7.02 -0.36 1.31e-11 Type 2 diabetes; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg10683054 chr6:132129037 ENPP1 0.36 5.97 0.31 6.01e-9 Liver disease severity in Alagille syndrome; CRC trans rs10504229 0.906 rs113823909 chr8:58170635 A/G cg04077850 chr5:125800366 GRAMD3 0.37 6.09 0.32 3.12e-9 Developmental language disorder (linguistic errors); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg10865849 chr10:48355149 ZNF488 0.45 6.45 0.34 3.95e-10 Response to antipsychotic treatment; CRC trans rs7615952 0.576 rs6780025 chr3:125815624 A/C cg07211511 chr3:129823064 LOC729375 -0.7 -9.29 -0.46 2.22e-18 Blood pressure (smoking interaction); CRC cis rs9911578 1.000 rs2333332 chr17:56631054 A/G cg12560992 chr17:57184187 TRIM37 -0.91 -16.78 -0.68 4.25e-46 Intelligence (multi-trait analysis); CRC cis rs11969893 0.850 rs9791284 chr6:101353886 G/A cg12253828 chr6:101329408 ASCC3 1.04 7.53 0.38 5.02e-13 Economic and political preferences (immigration/crime); CRC cis rs4930103 0.935 rs4930101 chr11:2021859 G/T cg23202291 chr11:1979235 NA 0.45 6.15 0.32 2.18e-9 DNA methylation (parent-of-origin);DNA methylation (variation); CRC cis rs7508679 1.000 rs4804411 chr19:7222377 G/C cg09779027 chr19:7224513 INSR 1.01 22.37 0.78 5.08e-68 Hypothyroidism; CRC cis rs2739330 0.761 rs5760176 chr22:24402321 A/G cg18538332 chr22:24372958 LOC391322 0.65 10.22 0.49 1.74e-21 Liver enzyme levels (gamma-glutamyl transferase); CRC trans rs61931739 0.500 rs10844862 chr12:34531965 A/T cg13010199 chr12:38710504 ALG10B 0.45 6.52 0.34 2.65e-10 Morning vs. evening chronotype; CRC cis rs1179624 0.679 rs62475464 chr7:75263197 G/A cg05145297 chr7:75264568 HIP1 0.57 7.63 0.39 2.61e-13 Age-related nuclear cataracts; CRC trans rs916888 0.779 rs199498 chr17:44865603 A/G cg01341218 chr17:43662625 NA 0.74 8.59 0.43 3.67e-16 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs548181 1.000 rs548181 chr11:125461709 A/G cg03464685 chr11:125439445 EI24 0.99 10.94 0.52 5.59e-24 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC trans rs4785204 1.000 rs7187350 chr16:50099036 C/A cg07960154 chr17:37760198 NEUROD2 -0.65 -6.05 -0.32 3.98e-9 Esophageal cancer (squamous cell); CRC trans rs13046373 0.905 rs4816372 chr21:32077414 A/T cg25957114 chr5:147582460 SPINK6 -0.43 -6.6 -0.34 1.62e-10 HDL cholesterol; CRC cis rs6952808 0.531 rs1107351 chr7:2177093 G/A cg04267008 chr7:1944627 MAD1L1 -0.62 -8.34 -0.42 2.04e-15 Bipolar disorder and schizophrenia; CRC cis rs1865760 0.566 rs2032449 chr6:26026599 G/C cg16482183 chr6:26056742 HIST1H1C 0.52 7.63 0.39 2.5e-13 Height; CRC cis rs1669338 0.507 rs4685609 chr3:3202279 T/C cg16797762 chr3:3221439 CRBN -0.63 -5.76 -0.3 1.92e-8 White matter integrity; CRC cis rs7727544 0.571 rs12521097 chr5:131575338 G/A cg02033258 chr5:131593261 PDLIM4 0.33 6.32 0.33 8.7e-10 Blood metabolite levels; CRC trans rs2303319 0.504 rs62187655 chr2:162487440 C/G cg22988483 chr14:93581567 ITPK1 -0.67 -6.03 -0.32 4.48e-9 Cognitive function; CRC cis rs853679 0.517 rs9366715 chr6:28064633 A/G cg03623178 chr6:28175578 NA 0.95 12.46 0.57 1.93e-29 Depression; CRC cis rs10924970 0.649 rs6697580 chr1:235484609 T/A cg09010748 chr1:235293032 TOMM20 -0.4 -5.65 -0.3 3.57e-8 Asthma; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg11802732 chr17:2206917 SRR;SMG6 0.47 6.11 0.32 2.79e-9 Thyroid stimulating hormone; CRC cis rs780096 0.526 rs1260342 chr2:27663416 G/T cg27432699 chr2:27873401 GPN1 -0.51 -7.82 -0.4 7.11e-14 Total body bone mineral density; CRC cis rs7119 0.679 rs12909808 chr15:77816944 A/G cg27398640 chr15:77910606 LINGO1 -0.43 -7.47 -0.38 7.13e-13 Type 2 diabetes; CRC cis rs6540556 0.637 rs12060922 chr1:209904433 G/A cg23920097 chr1:209922102 NA -0.5 -5.62 -0.3 4.07e-8 Red blood cell count; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg20611850 chr19:41284006 RAB4B 0.49 7.49 0.38 6.2800000000000005e-13 Liver disease severity in Alagille syndrome; CRC cis rs60871478 0.636 rs56393680 chr7:885696 A/G cg13844804 chr7:814759 HEATR2 -0.56 -5.88 -0.31 9.96e-9 Cerebrospinal P-tau181p levels; CRC trans rs2797160 0.651 rs6569436 chr6:126032104 A/G cg05039488 chr6:79577232 IRAK1BP1 0.54 8.27 0.41 3.39e-15 Endometrial cancer; CRC cis rs3858526 0.959 rs10838797 chr11:5920977 A/G cg05234568 chr11:5960015 NA -0.58 -7.94 -0.4 3.27e-14 DNA methylation (variation); CRC trans rs9545047 0.669 rs9545113 chr13:79996152 G/A cg07061582 chr15:90234082 PEX11A;WDR93 0.41 5.97 0.31 6.15e-9 Schizophrenia; CRC cis rs13082711 0.911 rs2370995 chr3:27428216 C/T cg02860705 chr3:27208620 NA 0.6 8.69 0.43 1.75e-16 Systolic blood pressure;Diastolic blood pressure;Blood pressure; CRC cis rs12291225 0.679 rs11023172 chr11:14295367 C/G cg05501817 chr11:14380813 RRAS2 -0.45 -5.96 -0.31 6.43e-9 Sense of smell; CRC cis rs933688 1.000 rs12656350 chr5:90751343 C/T cg26981201 chr5:90679533 LOC100129716;ARRDC3 0.98 15.09 0.64 1.79e-39 Smoking behavior; CRC cis rs28386778 0.863 rs2727355 chr17:61931790 C/T cg23090583 chr17:61904693 PSMC5;FTSJ3 1.03 19.93 0.74 1.63e-58 Prudent dietary pattern; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg24438655 chr17:45727598 KPNB1 0.46 6.57 0.34 1.95e-10 Response to antipsychotic treatment; CRC trans rs1455244 0.700 rs7229302 chr18:11508904 G/T cg13655586 chr7:111202389 IMMP2L 0.41 6.04 0.32 4.27e-9 Schizophrenia; CRC cis rs1949733 0.656 rs2688243 chr4:8436286 A/G cg13073564 chr4:8508604 NA -0.46 -7.09 -0.36 8.44e-12 Response to antineoplastic agents; CRC cis rs704795 0.775 rs4665975 chr2:27626017 A/T cg17158414 chr2:27665306 KRTCAP3 -0.29 -5.85 -0.31 1.16e-8 Menopause (age at onset); CRC cis rs7584330 0.554 rs3751107 chr2:238427251 G/A cg08992911 chr2:238395768 MLPH 0.47 5.75 0.3 2.04e-8 Prostate cancer; CRC cis rs1552244 0.554 rs13079240 chr3:10047246 C/T cg13047869 chr3:10149882 C3orf24 0.39 5.95 0.31 6.9e-9 Alzheimer's disease; CRC cis rs1008375 0.932 rs4698630 chr4:17614692 C/G cg16339924 chr4:17578868 LAP3 0.49 6.38 0.33 5.98e-10 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs6502050 0.835 rs8071737 chr17:80117537 T/C cg19223190 chr17:80058835 NA 0.39 6.25 0.33 1.27e-9 Life satisfaction; CRC cis rs9549367 0.789 rs6577035 chr13:113879997 G/A cg00898013 chr13:113819073 PROZ -0.46 -6.76 -0.35 6.2e-11 Platelet distribution width; CRC cis rs9858542 0.953 rs34588335 chr3:49407660 G/C cg00383909 chr3:49044727 WDR6 0.43 5.65 0.3 3.45e-8 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs9322193 0.607 rs3798763 chr6:150211100 T/C cg13206674 chr6:150067644 NUP43 0.48 5.84 0.31 1.28e-8 Lung cancer; CRC cis rs282587 0.569 rs373653 chr13:113406699 A/G cg04656015 chr13:113407548 ATP11A 0.58 7.45 0.38 8.25e-13 Glycated hemoglobin levels; CRC cis rs7799006 0.929 rs745566 chr7:2256406 T/C cg08027265 chr7:2291960 NA -0.4 -5.98 -0.31 5.8e-9 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs11168351 0.750 rs11168366 chr12:48421773 T/C cg24011408 chr12:48396354 COL2A1 -0.43 -6.14 -0.32 2.35e-9 Bipolar disorder and schizophrenia; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg05393045 chr10:119256233 EMX2OS 0.44 6.15 0.32 2.21e-9 Response to antipsychotic treatment; CRC cis rs1580019 0.587 rs10951338 chr7:32560089 A/G cg14728415 chr7:32535168 LSM5;AVL9 0.44 6.28 0.33 1.07e-9 Cognitive ability; CRC cis rs9768139 0.733 rs12698208 chr7:158117575 C/T cg25566285 chr7:158114605 PTPRN2 0.5 8.01 0.4 1.99e-14 Calcium levels; CRC cis rs9287719 0.967 rs7566767 chr2:10754663 T/C cg00105475 chr2:10696890 NA 0.45 7.1 0.36 7.95e-12 Prostate cancer; CRC cis rs780096 0.526 rs1260342 chr2:27663416 G/T cg02592271 chr2:27665507 KRTCAP3 -0.29 -6.69 -0.35 9.47e-11 Total body bone mineral density; CRC cis rs769267 0.930 rs7256149 chr19:19566255 T/C cg03709012 chr19:19516395 GATAD2A 0.73 11.46 0.53 7.95e-26 Tonsillectomy; CRC cis rs13392177 0.684 rs62185965 chr2:219073779 T/C cg04880052 chr2:219191631 PNKD -0.39 -5.88 -0.31 1.03e-8 Pyoderma gangrenosum in inflammatory bowel disease; CRC cis rs7172677 0.768 rs72730586 chr15:75354165 G/A cg14664628 chr15:75095509 CSK 0.52 6.31 0.33 9.22e-10 Systemic lupus erythematosus and Systemic sclerosis; CRC cis rs6840360 0.967 rs7684350 chr4:152672882 T/G cg09659197 chr4:152720779 NA 0.52 11.41 0.53 1.21e-25 Intelligence (multi-trait analysis); CRC cis rs16924133 0.793 rs67622484 chr11:33209057 A/G cg05567920 chr11:33183001 CSTF3 -0.78 -6.08 -0.32 3.39e-9 Anger; CRC cis rs67340775 0.541 rs200965 chr6:27866384 G/A cg02683197 chr6:28174875 NA 0.73 7.17 0.37 4.91e-12 Lung cancer in ever smokers; CRC cis rs644799 1.000 rs566204 chr11:95580926 G/A cg25622487 chr11:95524042 FAM76B;CEP57 0.76 11.91 0.55 1.95e-27 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs9926296 0.581 rs12598477 chr16:89902482 T/C cg27121462 chr16:89883253 FANCA 0.44 6.54 0.34 2.33e-10 Vitiligo; CRC cis rs7615952 0.599 rs67566088 chr3:125768973 C/A cg05084668 chr3:125655381 ALG1L -0.45 -6.46 -0.34 3.72e-10 Blood pressure (smoking interaction); CRC cis rs7618915 0.547 rs12487591 chr3:52642936 A/T cg10802521 chr3:52805072 NEK4 -0.57 -8.92 -0.44 3.24e-17 Bipolar disorder; CRC cis rs2658782 0.547 rs3020065 chr11:93059899 A/G cg15737290 chr11:93063684 CCDC67 0.67 10.73 0.51 3.2e-23 Pulmonary function decline; CRC cis rs7072216 1.000 rs7072216 chr10:100156853 A/G cg26618903 chr10:100175079 PYROXD2 -0.41 -7.14 -0.37 5.83e-12 Metabolite levels; CRC cis rs1215050 0.904 rs9307215 chr4:98813965 A/G cg05340658 chr4:99064831 C4orf37 0.44 5.93 0.31 7.81e-9 Waist-to-hip ratio adjusted for body mass index; CRC cis rs7591163 1.000 rs2396499 chr2:228724368 C/T cg14329157 chr2:228736135 WDR69 0.43 5.82 0.31 1.41e-8 Blood pressure; CRC cis rs2000999 0.514 rs35930480 chr16:72217681 G/A cg04254540 chr16:71951199 KIAA0174 -0.71 -5.79 -0.3 1.62e-8 Total cholesterol levels;Cholesterol, total;Blood protein levels;LDL cholesterol levels;Haptoglobin levels;LDL cholesterol; CRC cis rs4319547 0.774 rs10773394 chr12:123124778 C/A cg05707623 chr12:122985044 ZCCHC8 -0.49 -6.36 -0.33 6.69e-10 Body mass index; CRC cis rs875971 0.965 rs9969301 chr7:65781655 G/A cg18912574 chr7:65842487 NCRNA00174 -0.36 -6.27 -0.33 1.16e-9 Aortic root size; CRC cis rs1448094 0.506 rs61930640 chr12:86173333 T/C cg06740227 chr12:86229804 RASSF9 0.39 5.94 0.31 7.29e-9 Major depressive disorder; CRC cis rs1223397 0.702 rs1223400 chr6:13271242 T/C cg06879394 chr6:13274151 PHACTR1 0.55 6.61 0.34 1.55e-10 Blood pressure; CRC cis rs7659604 1.000 rs35249024 chr4:122664538 C/A cg19748678 chr4:122722346 EXOSC9 0.56 9.0 0.44 1.79e-17 Type 2 diabetes; CRC cis rs4653767 0.573 rs708770 chr1:226912135 C/T cg05049329 chr1:226924846 ITPKB 0.29 6.57 0.34 1.95e-10 Parkinson's disease; CRC cis rs9486719 0.857 rs2983897 chr6:97033780 C/T cg06623918 chr6:96969491 KIAA0776 -0.8 -11.32 -0.53 2.58e-25 Migraine;Coronary artery disease; CRC cis rs7811142 1.000 rs60478351 chr7:100089017 C/T cg00814883 chr7:100076585 TSC22D4 -0.74 -9.36 -0.46 1.31e-18 Platelet count; CRC cis rs7618915 0.571 rs6762457 chr3:52609157 G/A cg11645453 chr3:52864694 ITIH4 0.34 5.92 0.31 8.26e-9 Bipolar disorder; CRC cis rs9381040 0.655 rs2268188 chr6:41042590 T/G cg03644281 chr6:41068752 NFYA;LOC221442 -0.43 -5.99 -0.31 5.38e-9 Alzheimer's disease (late onset); CRC cis rs3760982 0.585 rs67648499 chr19:44294055 G/A cg11993925 chr19:44307056 LYPD5 0.56 10.08 0.49 5.18e-21 Breast cancer (estrogen-receptor negative);Breast cancer; CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg00995911 chr19:45004602 ZNF180 0.42 6.82 0.35 4.45e-11 Obesity-related traits; CRC cis rs7666738 0.830 rs58367603 chr4:99015350 T/C cg17366294 chr4:99064904 C4orf37 0.44 7.35 0.38 1.55e-12 Colonoscopy-negative controls vs population controls; CRC cis rs711830 1.000 rs1562315 chr2:177045482 T/A cg13092806 chr2:177043255 NA 0.74 9.46 0.46 5.9e-19 Serous invasive ovarian cancer;Epithelial ovarian cancer;Invasive epithelial ovarian cancer;Mucinous ovarian carcinoma;Low-grade serous and serous borderline ovarian cancer;Serous borderline ovarian cancer;High-grade serous ovarian cancer; CRC cis rs703842 1.000 rs10747783 chr12:58176614 T/C cg00677455 chr12:58241039 CTDSP2 0.64 8.61 0.43 3.15e-16 Multiple sclerosis; CRC cis rs7591163 0.959 rs2396497 chr2:228724139 T/C cg00063174 chr2:228736253 WDR69 -0.48 -6.48 -0.34 3.35e-10 Blood pressure; CRC cis rs4481887 1.000 rs4916125 chr1:248466583 A/T cg00666640 chr1:248458726 OR2T12 0.52 9.22 0.45 3.57e-18 Common traits (Other); CRC cis rs250677 0.687 rs36044 chr5:148441128 T/C cg18129178 chr5:148520854 ABLIM3 -0.36 -5.71 -0.3 2.51e-8 Breast cancer; CRC cis rs7223966 1.000 rs752621 chr17:61901880 G/C cg23090583 chr17:61904693 PSMC5;FTSJ3 0.57 6.74 0.35 7.09e-11 Hip circumference adjusted for BMI;Body mass index; CRC cis rs9311474 0.629 rs7639267 chr3:52568805 G/T cg18099408 chr3:52552593 STAB1 -0.64 -12.7 -0.57 2.33e-30 Electroencephalogram traits; CRC cis rs6502050 0.871 rs8066137 chr17:80074316 T/C cg02741985 chr17:80059408 CCDC57 -0.45 -7.4 -0.38 1.17e-12 Life satisfaction; CRC cis rs13118159 0.550 rs2878607 chr4:1353310 G/C cg02475777 chr4:1388615 CRIPAK 0.51 6.51 0.34 2.8e-10 Longevity; CRC cis rs875971 1.000 rs937495 chr7:65779798 A/G cg12463550 chr7:65579703 CRCP -0.5 -7.21 -0.37 3.79e-12 Aortic root size; CRC cis rs11098499 0.532 rs4504231 chr4:120586891 G/A cg09307838 chr4:120376055 NA 0.62 9.33 0.46 1.65e-18 Corneal astigmatism; CRC cis rs8009147 1 rs8009147 chr14:104264662 A/G cg01849466 chr14:104193079 ZFYVE21 -0.47 -8.39 -0.42 1.48e-15 Autism spectrum disorder or schizophrenia; CRC cis rs4268898 0.552 rs6754391 chr2:24369019 C/T cg06627628 chr2:24431161 ITSN2 -0.43 -6.73 -0.35 7.69e-11 Asthma; CRC cis rs4910157 1 rs4910157 chr11:8941215 A/G cg00186954 chr11:8933980 ST5;C11orf17 0.52 8.46 0.42 8.66e-16 Tonsillectomy; CRC cis rs4713118 0.513 rs202908 chr6:28011551 C/G cg12273811 chr6:28175739 NA 0.57 8.36 0.42 1.76e-15 Parkinson's disease; CRC cis rs1832871 0.711 rs9459924 chr6:158703902 G/A cg07165851 chr6:158734300 TULP4 0.61 7.75 0.39 1.15e-13 Height; CRC cis rs4713118 0.586 rs6905516 chr6:28086478 A/G cg18032046 chr6:28092343 ZSCAN16 -0.52 -6.02 -0.31 4.76e-9 Parkinson's disease; CRC cis rs875971 1.000 rs2420168 chr7:65630631 C/G cg12463550 chr7:65579703 CRCP -0.48 -6.97 -0.36 1.7e-11 Aortic root size; CRC cis rs7662987 0.517 rs2602858 chr4:100030461 T/C cg12011299 chr4:100065546 ADH4 0.49 9.27 0.46 2.46e-18 Smoking initiation; CRC cis rs8044868 0.530 rs8060770 chr16:72155694 C/A cg23815491 chr16:72088622 HP 0.46 6.78 0.35 5.69e-11 Body mass index (change over time) in cancer or chronic obstructive pulmonary disease;Body mass index (change over time) in cancer; CRC cis rs1223397 0.938 rs9381884 chr6:13278788 A/G cg00460589 chr6:13274354 PHACTR1 0.46 5.82 0.31 1.4e-8 Blood pressure; CRC cis rs10504229 0.906 rs56130194 chr8:58197061 C/A cg05313129 chr8:58192883 C8orf71 -0.48 -5.89 -0.31 9.7e-9 Developmental language disorder (linguistic errors); CRC cis rs5167 0.504 rs7258345 chr19:45453151 T/G cg13119609 chr19:45449297 APOC2 0.32 6.02 0.32 4.62e-9 Blood protein levels; CRC cis rs6951245 0.554 rs35126802 chr7:1134842 C/T cg03188948 chr7:1209495 NA 0.49 5.83 0.31 1.3e-8 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs2952156 0.920 rs11078919 chr17:37835755 T/C cg20243544 chr17:37824526 PNMT 0.56 9.01 0.44 1.72e-17 Asthma; CRC cis rs853679 0.760 rs11967137 chr6:28199764 A/G cg12172441 chr6:28176163 NA 0.56 5.8 0.3 1.54e-8 Depression; CRC trans rs2303319 0.504 rs62189042 chr2:162602320 G/T cg04551154 chr10:95462393 C10orf4 -0.75 -6.37 -0.33 6.43e-10 Cognitive function; CRC cis rs8067545 0.750 rs11871651 chr17:19997425 T/C cg13482628 chr17:19912719 NA 0.47 7.46 0.38 7.83e-13 Schizophrenia; CRC cis rs1552244 0.935 rs35148833 chr3:10116937 C/A cg13047869 chr3:10149882 C3orf24 0.57 7.8 0.4 8.27e-14 Alzheimer's disease; CRC cis rs7647973 0.925 rs4955421 chr3:49218888 G/A cg20833759 chr3:49053208 WDR6;DALRD3 0.55 8.49 0.42 7.08e-16 Menarche (age at onset); CRC cis rs1451375 1.000 rs921450 chr7:50623260 A/G cg14593290 chr7:50529359 DDC -0.54 -7.53 -0.38 4.84e-13 Malaria; CRC cis rs7615952 0.611 rs35321002 chr3:125612065 G/C cg05084668 chr3:125655381 ALG1L -0.7 -9.08 -0.45 1.01e-17 Blood pressure (smoking interaction); CRC cis rs3857536 0.785 rs2157964 chr6:66938419 A/G cg07460842 chr6:66804631 NA -0.43 -5.81 -0.3 1.48e-8 Blood trace element (Cu levels); CRC cis rs7246657 0.943 rs12709813 chr19:37844983 G/A cg23950597 chr19:37808831 NA -0.47 -5.76 -0.3 1.94e-8 Coronary artery calcification; CRC cis rs6938 0.534 rs8025447 chr15:75192222 T/G cg05627522 chr15:75251581 NA 0.38 5.83 0.31 1.33e-8 Breast cancer; CRC cis rs4285028 0.796 rs12638492 chr3:121711763 G/A cg11130432 chr3:121712080 ILDR1 -0.49 -6.1 -0.32 2.97e-9 Multiple sclerosis; CRC cis rs8141797 0.901 rs5751811 chr22:24570772 G/A cg20894457 chr22:24584366 SUSD2 0.66 6.51 0.34 2.77e-10 Amyotrophic lateral sclerosis;Coronary artery disease; CRC cis rs2404602 0.716 rs12594577 chr15:76828793 A/C cg03037974 chr15:76606532 NA 0.72 12.67 0.57 3.16e-30 Blood metabolite levels; CRC cis rs10779751 1.000 rs11121710 chr1:11313244 T/C cg08854313 chr1:11322531 MTOR 0.69 9.75 0.47 6.98e-20 Body mass index; CRC cis rs526821 0.595 rs532278 chr11:55344983 A/G cg04317927 chr11:55418816 OR4S2 0.39 6.63 0.34 1.37e-10 Pediatric bone mineral density (spine); CRC cis rs7665939 0.860 rs72709247 chr4:190126086 A/G cg09826759 chr4:190284978 NA -0.65 -5.64 -0.3 3.58e-8 Amyotrophic lateral sclerosis; CRC cis rs2576037 0.583 rs9947131 chr18:44534769 G/T cg19077165 chr18:44547161 KATNAL2 -0.66 -10.78 -0.51 2.12e-23 Personality dimensions; CRC cis rs9916302 0.904 rs9905432 chr17:37555918 C/A cg00129232 chr17:37814104 STARD3 0.54 8.12 0.41 9.26e-15 Glomerular filtration rate (creatinine); CRC cis rs4665809 1.000 rs4665306 chr2:26319124 C/T cg26119090 chr2:26468346 HADHA;HADHB -0.61 -7.91 -0.4 3.92e-14 Gut microbiome composition (summer); CRC cis rs12318506 0.793 rs71460129 chr12:75699427 C/T cg04728562 chr12:75699417 CAPS2 -0.96 -7.25 -0.37 2.91e-12 Coronary artery calcification; CRC cis rs1862618 0.511 rs2591952 chr5:56120769 T/A cg12311346 chr5:56204834 C5orf35 -0.76 -10.06 -0.48 6.3e-21 Initial pursuit acceleration; CRC cis rs56114371 0.777 rs200482 chr6:27773904 G/A cg15845792 chr6:28175446 NA 0.73 6.48 0.34 3.27e-10 Breast cancer; CRC cis rs1552244 0.935 rs4441636 chr3:10083876 G/A cg08888203 chr3:10149979 C3orf24 0.73 9.96 0.48 1.34e-20 Alzheimer's disease; CRC cis rs35306767 0.623 rs34034003 chr10:1143435 G/A cg26597838 chr10:835615 NA 0.67 7.69 0.39 1.75e-13 Eosinophil percentage of granulocytes; CRC cis rs1552244 0.832 rs66597916 chr3:10195407 T/C cg13047869 chr3:10149882 C3orf24 0.56 6.66 0.34 1.15e-10 Alzheimer's disease; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg05815920 chr10:103880348 LDB1 -0.42 -6.64 -0.34 1.32e-10 Myopia (pathological); CRC cis rs4728302 0.869 rs12707129 chr7:133593177 A/G cg03336402 chr7:133662267 EXOC4 -0.45 -6.56 -0.34 2.04e-10 Intelligence;Intelligence (multi-trait analysis); CRC cis rs10751667 0.666 rs7395488 chr11:954111 T/C cg23136738 chr11:925521 AP2A2 -0.42 -7.05 -0.36 1.03e-11 Alzheimer's disease (late onset); CRC cis rs6918586 0.658 rs198813 chr6:26128226 C/T cg18357526 chr6:26021779 HIST1H4A -0.5 -7.47 -0.38 7.38e-13 Schizophrenia; CRC cis rs7635838 0.750 rs2648463 chr3:11403857 G/A cg00170343 chr3:11313890 ATG7 0.45 7.05 0.36 1.05e-11 HDL cholesterol; CRC cis rs4700695 0.841 rs784276 chr5:65317332 A/T cg21114390 chr5:65439923 SFRS12 0.51 6.37 0.33 6.55e-10 Facial morphology (factor 19); CRC cis rs853679 0.517 rs9393884 chr6:28046789 A/G cg18032046 chr6:28092343 ZSCAN16 -0.48 -5.71 -0.3 2.54e-8 Depression; CRC cis rs1799949 0.931 rs34474989 chr17:41445410 A/T cg25072359 chr17:41440525 NA 0.5 8.07 0.41 1.3e-14 Menopause (age at onset); CRC cis rs3099143 1.000 rs3102710 chr15:77061148 T/C cg21673338 chr15:77095150 SCAPER -0.75 -7.87 -0.4 5.12e-14 Recalcitrant atopic dermatitis; CRC cis rs5417 0.788 rs2654185 chr17:7183362 G/T cg25256661 chr17:7137939 DVL2 0.66 11.69 0.54 1.19e-26 Diastolic blood pressure; CRC cis rs12497850 0.931 rs7647813 chr3:48833348 G/T cg20833759 chr3:49053208 WDR6;DALRD3 0.51 8.74 0.43 1.19e-16 Parkinson's disease; CRC cis rs4665809 0.590 rs6730317 chr2:26419482 C/T cg04944784 chr2:26401820 FAM59B -0.88 -11.59 -0.54 2.9e-26 Gut microbiome composition (summer); CRC cis rs7191700 0.712 rs7187741 chr16:11433103 C/G cg00044050 chr16:11439710 C16orf75 -0.53 -7.91 -0.4 3.89e-14 Multiple sclerosis; CRC cis rs6502050 0.835 rs7208673 chr17:80165908 G/C cg02741985 chr17:80059408 CCDC57 0.43 7.23 0.37 3.4e-12 Life satisfaction; CRC cis rs473651 0.740 rs502349 chr2:239318389 C/T cg21699342 chr2:239360505 ASB1 0.52 9.12 0.45 7.76e-18 Multiple system atrophy; CRC cis rs4654899 0.802 rs6426648 chr1:21179527 A/G cg02927042 chr1:21476669 EIF4G3 -0.5 -7.93 -0.4 3.35e-14 Superior frontal gyrus grey matter volume; CRC cis rs34172651 0.876 rs2112785 chr16:24781176 C/T cg06028605 chr16:24865363 SLC5A11 0.4 7.55 0.38 4.39e-13 Intelligence (multi-trait analysis); CRC cis rs853679 0.517 rs3823180 chr6:28061744 G/A cg03623178 chr6:28175578 NA 0.96 12.48 0.57 1.62e-29 Depression; CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg10354764 chr16:3285464 ZNF200 -0.54 -6.63 -0.34 1.34e-10 Diisocyanate-induced asthma; CRC cis rs2404602 0.684 rs62026898 chr15:76944371 C/A cg23625390 chr15:77176239 SCAPER -0.86 -14.11 -0.61 1.06e-35 Blood metabolite levels; CRC cis rs2721195 0.719 rs4925811 chr8:145802447 G/T cg15320075 chr8:145703422 NA -0.53 -8.16 -0.41 6.95e-15 Age at first birth; CRC cis rs2625529 0.730 rs7403191 chr15:72160964 C/T cg16672083 chr15:72433130 SENP8 -0.45 -6.48 -0.34 3.29e-10 Red blood cell count; CRC cis rs969413 0.624 rs7213540 chr17:79255912 C/T cg17393016 chr17:79283390 C17orf55 -0.28 -5.77 -0.3 1.84e-8 Frontotemporal dementia; CRC cis rs6840360 0.573 rs4696249 chr4:152264647 A/G cg09659197 chr4:152720779 NA 0.33 6.37 0.33 6.19e-10 Intelligence (multi-trait analysis); CRC cis rs853679 0.517 rs9368556 chr6:28131153 T/C cg12963246 chr6:28129442 ZNF389 0.49 5.7 0.3 2.71e-8 Depression; CRC cis rs7524258 0.903 rs4908608 chr1:7292772 T/C cg07173049 chr1:7289937 CAMTA1 0.67 10.69 0.51 4.24e-23 Tourette's syndrome or obsessive-compulsive disorder; CRC cis rs9902453 1.000 rs9912741 chr17:28359511 G/A cg26525008 chr17:28256777 EFCAB5;SSH2 -0.59 -8.78 -0.44 8.99e-17 Coffee consumption (cups per day); CRC cis rs1552244 1.000 rs9879080 chr3:10084224 C/T cg18598329 chr3:10140678 FANCD2;C3orf24 -0.89 -12.69 -0.57 2.6e-30 Alzheimer's disease; CRC cis rs6712932 0.962 rs10496390 chr2:105838791 C/T cg27422857 chr2:105853526 NA -0.36 -6.71 -0.35 8.32e-11 Type 2 diabetes; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg24823993 chr22:42085003 NHP2L1 0.47 7.12 0.37 6.77e-12 Intelligence (multi-trait analysis); CRC cis rs9942416 0.617 rs72633979 chr5:74990178 A/T cg19683494 chr5:74908142 NA 0.49 6.05 0.32 3.97e-9 Age-related disease endophenotypes; CRC cis rs4253772 0.637 rs8139035 chr22:46651367 A/G cg24881330 chr22:46731750 TRMU 0.56 6.63 0.34 1.35e-10 LDL cholesterol;Cholesterol, total; CRC cis rs9549367 0.713 rs1755690 chr13:113824266 T/C cg00898013 chr13:113819073 PROZ 0.51 7.69 0.39 1.77e-13 Platelet distribution width; CRC cis rs910316 0.737 rs28687415 chr14:75495482 T/C cg11812906 chr14:75593930 NEK9 0.59 9.27 0.46 2.49e-18 Height; CRC cis rs873946 0.586 rs12783078 chr10:134569706 C/T cg26818010 chr10:134567672 INPP5A -0.72 -9.29 -0.46 2.14e-18 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CRC cis rs6840360 0.642 rs2709822 chr4:152351500 A/G cg09659197 chr4:152720779 NA 0.34 6.69 0.35 9.53e-11 Intelligence (multi-trait analysis); CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg09580147 chr16:22431764 RRN3P3 0.46 6.86 0.35 3.35e-11 Myopia (pathological); CRC cis rs7584330 0.704 rs72620820 chr2:238358844 G/A cg16989719 chr2:238392110 NA -0.41 -6.69 -0.35 9.51e-11 Prostate cancer; CRC cis rs6500395 0.775 rs1968902 chr16:48663974 A/G cg04672837 chr16:48644449 N4BP1 0.43 6.5 0.34 3.06e-10 Response to tocilizumab in rheumatoid arthritis; CRC cis rs12024301 0.557 rs6658064 chr1:183621175 A/G cg11505048 chr1:183622726 RGL1;APOBEC4 0.81 7.0 0.36 1.42e-11 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs2898681 0.580 rs41279517 chr4:53729771 T/C cg00791764 chr4:53727839 RASL11B 0.59 6.29 0.33 1.02e-9 Optic nerve measurement (cup area); CRC cis rs9311676 0.656 rs7647184 chr3:58370046 C/T cg06643156 chr3:58380774 PXK 0.42 6.39 0.33 5.78e-10 Systemic lupus erythematosus; CRC cis rs6679356 0.789 rs1908632 chr1:67805806 G/T cg24364144 chr1:67875067 SERBP1 0.41 6.24 0.33 1.38e-9 Primary biliary cholangitis; CRC cis rs4713118 0.662 rs4713120 chr6:27721835 C/A cg15786705 chr6:28176104 NA 0.47 6.84 0.35 3.92e-11 Parkinson's disease; CRC cis rs2066819 1.000 rs77768890 chr12:56725121 A/G cg26714650 chr12:56694279 CS -1.41 -11.51 -0.54 5.39e-26 Psoriasis vulgaris; CRC cis rs7312933 0.558 rs4768399 chr12:42742696 G/A cg11827402 chr12:42719852 PPHLN1;ZCRB1 -0.67 -9.87 -0.48 2.66e-20 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CRC cis rs2797160 0.874 rs58305111 chr6:126008386 G/T cg05901451 chr6:126070800 HEY2 0.41 6.2 0.32 1.68e-9 Endometrial cancer; CRC cis rs654950 0.783 rs639298 chr1:42001530 A/G cg06885757 chr1:42089581 HIVEP3 -0.34 -5.97 -0.31 6.23e-9 Airway imaging phenotypes; CRC cis rs35264875 1.000 rs72928644 chr11:68849845 A/G cg01993067 chr11:68851601 TPCN2 0.56 6.33 0.33 7.99e-10 Blond vs. brown hair color; CRC cis rs7264396 0.887 rs4911510 chr20:34093153 G/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.39 -6.55 -0.34 2.26e-10 Total cholesterol levels; CRC cis rs6748734 1.000 rs4293565 chr2:241834770 A/G cg04034577 chr2:241836375 C2orf54 -0.42 -8.8 -0.44 8.16e-17 Urinary metabolites; CRC cis rs1355223 0.867 rs1869360 chr11:34698590 C/T cg11058730 chr11:34937778 PDHX;APIP -0.41 -5.7 -0.3 2.69e-8 Systemic lupus erythematosus and Systemic sclerosis; CRC cis rs2075371 0.829 rs1993058 chr7:133930361 G/A cg20476274 chr7:133979776 SLC35B4 0.7 11.26 0.53 4.22e-25 Mean platelet volume; CRC cis rs3087591 1.000 rs2952980 chr17:29473353 G/A cg24425628 chr17:29625626 OMG;NF1 0.84 15.45 0.65 7.12e-41 Hip circumference; CRC cis rs514406 0.644 rs6661196 chr1:53203664 A/G cg27535305 chr1:53392650 SCP2 0.34 6.32 0.33 8.34e-10 Monocyte count; CRC cis rs13256369 1.000 rs885000 chr8:8568875 G/T cg18904891 chr8:8559673 CLDN23 0.52 6.97 0.36 1.76e-11 Obesity-related traits; CRC cis rs2404602 0.692 rs58973160 chr15:77000342 T/C cg22467129 chr15:76604101 ETFA -0.43 -7.09 -0.36 8.44e-12 Blood metabolite levels; CRC cis rs3026101 0.671 rs3026115 chr17:5285222 C/T cg25236894 chr17:5323110 RPAIN;NUP88 0.45 7.55 0.38 4.31e-13 Body mass index; CRC cis rs7527798 0.592 rs960088 chr1:207827067 A/C cg09232269 chr1:207846808 CR1L -0.45 -7.31 -0.37 2.02e-12 Erythrocyte sedimentation rate; CRC trans rs7615952 1.000 rs9289275 chr3:125648659 A/T cg07211511 chr3:129823064 LOC729375 -1.1 -18.2 -0.71 1.07e-51 Blood pressure (smoking interaction); CRC trans rs7829975 0.593 rs2921077 chr8:8304502 C/T cg16141378 chr3:129829833 LOC729375 -0.45 -6.8 -0.35 4.97e-11 Mood instability; CRC cis rs59104589 1.000 rs59104589 chr2:242237902 C/T cg10021735 chr2:242295487 FARP2 0.44 5.98 0.31 5.69e-9 Fibrinogen levels; CRC cis rs9902453 1.000 rs4239227 chr17:28389103 A/C cg26525008 chr17:28256777 EFCAB5;SSH2 -0.59 -8.86 -0.44 4.95e-17 Coffee consumption (cups per day); CRC trans rs1455244 0.700 rs7229302 chr18:11508904 G/T cg14952089 chr5:126366488 MARCH3 0.41 6.14 0.32 2.4e-9 Schizophrenia; CRC cis rs4689388 0.853 rs13114527 chr4:6294655 T/G cg25554036 chr4:6271136 WFS1 0.53 8.7 0.43 1.59e-16 Type 2 diabetes and other traits;Type 2 diabetes; CRC cis rs6740322 0.895 rs13384080 chr2:43557363 C/T cg06169590 chr2:43455088 ZFP36L2;LOC100129726 -0.64 -7.79 -0.39 8.68e-14 Coronary artery disease; CRC cis rs597539 0.652 rs496616 chr11:68672800 G/C cg06028808 chr11:68637592 NA 0.42 6.67 0.35 1.09e-10 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs4862750 0.832 rs6836076 chr4:187899660 A/C cg22105103 chr4:187893119 NA 0.64 11.71 0.54 1.01e-26 Lobe attachment (rater-scored or self-reported); CRC cis rs9733 0.596 rs6587516 chr1:150623221 C/T cg18016565 chr1:150552671 MCL1 0.46 6.74 0.35 6.91e-11 Tonsillectomy; CRC cis rs4746091 1.000 rs61650587 chr10:73398722 G/A cg22763136 chr10:73395000 CDH23 0.42 6.18 0.32 1.91e-9 Selective IgA deficiency; CRC cis rs1519814 1.000 rs4871041 chr8:121136584 C/T cg22335954 chr8:121166405 COL14A1 -0.56 -6.44 -0.33 4.13e-10 Breast cancer; CRC cis rs3858526 0.527 rs10839168 chr11:6002798 A/G cg05234568 chr11:5960015 NA 0.4 6.06 0.32 3.74e-9 DNA methylation (variation); CRC trans rs9291683 0.526 rs6827785 chr4:10018205 C/T cg26043149 chr18:55253948 FECH 0.5 7.46 0.38 7.7e-13 Bone mineral density; CRC cis rs13108904 0.967 rs62293658 chr4:1276416 T/C cg19318889 chr4:1322082 MAEA -0.41 -6.38 -0.33 5.88e-10 Obesity-related traits; CRC cis rs73001065 0.636 rs11668104 chr19:19426181 G/A cg03709012 chr19:19516395 GATAD2A 0.83 7.01 0.36 1.34e-11 LDL cholesterol; CRC cis rs9846480 0.598 rs6439804 chr3:138056550 T/C cg25476813 chr3:138050155 TXNDC6 -0.38 -5.73 -0.3 2.24e-8 Whole-brain volume (Alzheimer's disease interaction); CRC cis rs9811920 0.609 rs13317017 chr3:99665521 A/C cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G -0.46 -6.18 -0.32 1.91e-9 Axial length; CRC cis rs9992667 0.955 rs73232876 chr4:38647509 C/T cg19726192 chr4:38663646 FLJ13197 -0.69 -8.6 -0.43 3.27e-16 Eosinophil percentage of granulocytes; CRC cis rs10504229 0.683 rs61364624 chr8:58134339 T/A cg05313129 chr8:58192883 C8orf71 -0.43 -6.11 -0.32 2.74e-9 Developmental language disorder (linguistic errors); CRC cis rs2361710 0.668 rs2304855 chr17:78118266 T/A cg20811857 chr17:78079795 GAA -0.4 -6.33 -0.33 8.05e-10 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count;Immature fraction of reticulocytes; CRC cis rs5750830 0.649 rs6001588 chr22:39819049 G/C cg25459000 chr22:39777742 SYNGR1 -0.34 -6.05 -0.32 3.91e-9 Intelligence (multi-trait analysis); CRC cis rs12701220 0.948 rs12690826 chr7:1081618 A/G cg26769984 chr7:1090371 C7orf50 0.75 10.43 0.5 3.54e-22 Bronchopulmonary dysplasia; CRC cis rs9611565 0.649 rs4822050 chr22:42177453 C/G cg03806693 chr22:41940476 POLR3H -0.63 -8.68 -0.43 1.82e-16 Vitiligo; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg00814883 chr7:100076585 TSC22D4 0.44 6.98 0.36 1.65e-11 Liver disease severity in Alagille syndrome; CRC cis rs6499255 0.904 rs7187653 chr16:69562838 G/C cg15192750 chr16:69999425 NA 0.52 6.97 0.36 1.71e-11 IgE levels; CRC cis rs8060686 0.641 rs12600199 chr16:68069742 C/T cg26727032 chr16:67993705 SLC12A4 -0.57 -6.26 -0.33 1.2e-9 HDL cholesterol;Metabolic syndrome; CRC cis rs9443645 0.901 rs1354831 chr6:79613576 T/C cg05283184 chr6:79620031 NA -0.58 -9.28 -0.46 2.26e-18 Intelligence (multi-trait analysis); CRC trans rs10242455 0.702 rs55927283 chr7:99057191 G/C cg09045935 chr12:6379348 NA 1.03 8.84 0.44 5.85e-17 Blood metabolite levels; CRC cis rs11608355 1.000 rs2075439 chr12:109859374 A/G cg19025524 chr12:109796872 NA -0.47 -6.72 -0.35 8.22e-11 Neuroticism; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg04465201 chr20:32699025 EIF2S2 0.45 6.47 0.34 3.57e-10 Response to antipsychotic treatment; CRC cis rs9549328 0.837 rs9549618 chr13:113628648 G/A cg17524180 chr13:113633600 MCF2L -0.68 -12.82 -0.58 8.76e-31 Systolic blood pressure; CRC cis rs8114671 0.562 rs2076667 chr20:33506964 G/A cg07148914 chr20:33460835 GGT7 0.39 6.41 0.33 4.92e-10 Height; CRC cis rs72615157 0.697 rs2056726 chr7:99780283 G/A cg19337854 chr7:99768885 GPC2 0.47 6.29 0.33 9.99e-10 Lung function (FEV1/FVC); CRC trans rs6550704 0.687 rs9865314 chr3:22634337 A/G cg25947998 chr8:42948467 SGK196 -0.41 -6.06 -0.32 3.68e-9 Daytime sleep phenotypes; CRC cis rs2933343 0.729 rs789230 chr3:128602558 G/A cg25356066 chr3:128598488 ACAD9 0.39 5.69 0.3 2.82e-8 IgG glycosylation; CRC cis rs28374715 0.662 rs16971558 chr15:41458619 G/A cg18705301 chr15:41695430 NDUFAF1 -0.85 -12.75 -0.57 1.62e-30 Ulcerative colitis; CRC cis rs514406 0.861 rs7513052 chr1:53241360 C/T cg24675658 chr1:53192096 ZYG11B 0.6 9.42 0.46 8.36e-19 Monocyte count; CRC cis rs7264396 0.635 rs2024854 chr20:34511189 T/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.61 -10.11 -0.49 4.33e-21 Total cholesterol levels; CRC trans rs1814175 0.817 rs7927373 chr11:49957640 A/C cg15704280 chr7:45808275 SEPT13 -0.97 -18.82 -0.72 3.98e-54 Height; CRC cis rs9486719 0.749 rs1009596 chr6:96843688 A/G cg06623918 chr6:96969491 KIAA0776 0.79 8.57 0.43 4.23e-16 Migraine;Coronary artery disease; CRC cis rs9814567 1.000 rs13081688 chr3:134259954 C/T cg06109529 chr3:134205091 CEP63;ANAPC13 0.83 12.22 0.56 1.46e-28 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs9733 0.596 rs11204687 chr1:150629880 C/A cg17724175 chr1:150552817 MCL1 0.58 9.4 0.46 9.25e-19 Tonsillectomy; CRC cis rs6951245 0.572 rs79489623 chr7:1045632 C/T cg20603222 chr7:1096387 C7orf50;GPR146 -0.74 -6.03 -0.32 4.32e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs2188554 0.740 rs213948 chr7:117194470 G/A cg09181792 chr7:117119393 CFTR 0.33 5.95 0.31 6.94e-9 Esophageal adenocarcinoma; CRC cis rs4253772 0.550 rs739164 chr22:46684558 C/T cg03482458 chr22:46692211 CN5H6.4;GTSE1 -0.54 -7.16 -0.37 5.45e-12 LDL cholesterol;Cholesterol, total; CRC cis rs7953249 0.618 rs7954039 chr12:121398654 A/C cg02403541 chr12:121454288 C12orf43 -0.42 -5.99 -0.31 5.36e-9 Invasive epithelial ovarian cancer;High-grade serous ovarian cancer;Chronic obstructive pulmonary disease-related biomarkers;N-glycan levels;Serous invasive ovarian cancer;Epithelial ovarian cancer; CRC cis rs7772486 0.790 rs2254283 chr6:146204289 T/C cg13319975 chr6:146136371 FBXO30 -0.39 -5.9 -0.31 8.88e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs4563143 0.514 rs73030738 chr19:29312328 G/A cg12667521 chr19:29218732 NA 0.51 7.09 0.36 8.18e-12 Methadone dose in opioid dependence; CRC cis rs8014204 0.836 rs888413 chr14:75267396 C/T cg03030879 chr14:75389066 RPS6KL1 -0.49 -7.82 -0.4 7.17e-14 Caffeine consumption; CRC cis rs9462846 0.691 rs7744454 chr6:42914041 C/G cg27588902 chr6:42928151 GNMT -0.36 -5.72 -0.3 2.34e-8 Blood protein levels; CRC cis rs4713118 0.588 rs200994 chr6:27813813 A/C cg21251018 chr6:28226885 NKAPL -0.46 -6.5 -0.34 2.9e-10 Parkinson's disease; CRC cis rs2576037 0.899 rs12955429 chr18:44585484 C/T cg07416455 chr18:44543612 TCEB3CL;KATNAL2 0.52 7.55 0.38 4.43e-13 Personality dimensions; CRC trans rs10982213 0.830 rs2274163 chr9:117188714 C/T cg02190572 chr10:74057806 NA 0.4 6.17 0.32 2.02e-9 Interleukin-6 levels; CRC cis rs644799 0.526 rs506180 chr11:95623109 G/A cg03916912 chr11:95522834 CEP57;FAM76B 0.66 10.82 0.51 1.53e-23 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs832540 0.866 rs252894 chr5:56224339 A/C cg24531977 chr5:56204891 C5orf35 0.43 6.37 0.33 6.54e-10 Coronary artery disease; CRC cis rs10779751 1.000 rs4845859 chr1:11304873 A/G cg08854313 chr1:11322531 MTOR 0.68 9.63 0.47 1.72e-19 Body mass index; CRC cis rs6960043 0.738 rs10266209 chr7:15058691 C/T cg19272540 chr7:15055459 NA -0.24 -6.4 -0.33 5.26e-10 Type 2 diabetes; CRC cis rs9858542 0.953 rs11706370 chr3:49441091 G/A cg03060546 chr3:49711283 APEH -0.48 -6.81 -0.35 4.64e-11 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs11785693 0.862 rs6994150 chr8:4996630 T/G cg26367366 chr8:4980734 NA 0.8 10.02 0.48 8.79e-21 Neuroticism (multi-trait analysis);Neuroticism; CRC cis rs228769 0.543 rs170634 chr17:42175821 C/A cg09913183 chr17:42254507 C17orf65;ASB16 -0.48 -6.62 -0.34 1.44e-10 Bone mineral density (hip);Bone mineral density (spine); CRC cis rs6860806 0.507 rs272872 chr5:131675864 C/T cg27615366 chr5:131592974 PDLIM4 -0.32 -5.77 -0.3 1.79e-8 Breast cancer; CRC cis rs6540556 0.723 rs9430012 chr1:209900615 G/C cg23920097 chr1:209922102 NA -0.5 -5.66 -0.3 3.25e-8 Red blood cell count; CRC cis rs10197940 0.662 rs4467261 chr2:152281391 G/C cg19508488 chr2:152266495 RIF1 0.52 7.65 0.39 2.2e-13 Lung cancer; CRC trans rs473651 0.904 rs501333 chr2:239336045 G/A cg13521940 chr21:36262239 RUNX1 -0.41 -6.07 -0.32 3.54e-9 Multiple system atrophy; CRC cis rs734999 0.566 rs6664969 chr1:2534978 G/A cg20673091 chr1:2541236 MMEL1 0.37 5.91 0.31 8.46e-9 Ulcerative colitis; CRC cis rs17095355 1.000 rs17126890 chr10:111699169 T/C cg00817464 chr10:111662876 XPNPEP1 -0.61 -8.27 -0.41 3.31e-15 Biliary atresia; CRC cis rs2732480 0.538 rs2468943 chr12:48747249 G/T cg04545296 chr12:48745243 ZNF641 -0.37 -6.49 -0.34 3.08e-10 Hemoglobin concentration;Red blood cell count;Hematocrit; CRC cis rs9326248 0.954 rs4938349 chr11:117021923 C/T cg26566898 chr11:117069891 TAGLN 0.44 9.45 0.46 6.74e-19 Blood protein levels; CRC cis rs6088580 0.524 rs2378251 chr20:33276750 C/T cg08999081 chr20:33150536 PIGU -0.37 -5.64 -0.3 3.71e-8 Glomerular filtration rate (creatinine); CRC cis rs6951245 0.507 rs11976805 chr7:1138716 C/T cg22907277 chr7:1156413 C7orf50 0.8 10.99 0.52 3.77e-24 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs10512697 0.803 rs77728185 chr5:3577798 T/A cg19473799 chr5:3511975 NA -0.73 -5.8 -0.3 1.53e-8 Immune response to smallpox vaccine (IL-6); CRC cis rs2153535 0.580 rs5001322 chr6:8451608 A/G cg21535247 chr6:8435926 SLC35B3 0.5 7.45 0.38 8.15e-13 Motion sickness; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg05030574 chr11:65189075 NEAT1 0.49 6.98 0.36 1.61e-11 Response to antipsychotic treatment; CRC cis rs28386778 0.897 rs2156903 chr17:61937179 G/A cg22520471 chr17:61851767 DDX42;CCDC47 0.73 11.47 0.53 7.78e-26 Prudent dietary pattern; CRC cis rs3733585 0.699 rs2018643 chr4:9947121 C/T cg11266682 chr4:10021025 SLC2A9 0.46 9.23 0.45 3.47e-18 Cleft plate (environmental tobacco smoke interaction); CRC cis rs9470366 0.816 rs1321311 chr6:36622900 C/A cg08179530 chr6:36648295 CDKN1A 0.49 5.77 0.3 1.87e-8 QRS duration; CRC cis rs8180040 0.903 rs2276853 chr3:47282303 G/A cg02527881 chr3:46936655 PTH1R -0.38 -7.03 -0.36 1.22e-11 Colorectal cancer; CRC cis rs17234274 0.644 rs1947939 chr11:23221739 T/C cg05245346 chr11:23248277 NA 0.35 5.75 0.3 2.02e-8 Cancer; CRC cis rs6433857 0.536 rs1901750 chr2:181350739 C/T cg23363182 chr2:181467187 NA -0.53 -7.92 -0.4 3.82e-14 Body mass index; CRC cis rs2354432 0.556 rs2353975 chr1:146837703 C/A cg25205988 chr1:146714368 CHD1L 1.15 9.97 0.48 1.26e-20 Mitochondrial DNA levels; CRC cis rs1865760 0.613 rs9379801 chr6:25901711 T/C cg17691542 chr6:26056736 HIST1H1C 0.45 6.82 0.35 4.32e-11 Height; CRC cis rs514406 0.830 rs533935 chr1:53308807 T/C cg08859206 chr1:53392774 SCP2 -0.43 -6.79 -0.35 5.36e-11 Monocyte count; CRC cis rs1223397 0.651 rs957175 chr6:13311243 C/T cg20827128 chr6:13274284 PHACTR1 0.38 5.81 0.3 1.5e-8 Blood pressure; CRC cis rs2976388 0.578 rs13254358 chr8:143823876 G/A cg10596483 chr8:143751796 JRK -0.49 -6.67 -0.35 1.09e-10 Urinary tract infection frequency; CRC cis rs561341 1.000 rs2470243 chr17:30290955 C/T cg12193833 chr17:30244370 NA -0.75 -8.72 -0.43 1.4e-16 Hip circumference adjusted for BMI; CRC trans rs12481514 0.702 rs73586667 chr20:4303278 T/C cg11071926 chr1:116380316 NHLH2 -0.52 -6.1 -0.32 2.91e-9 Paneth cell defects in Crohn's disease; CRC cis rs1451375 0.652 rs7803440 chr7:50625632 C/T cg14593290 chr7:50529359 DDC 0.59 7.9 0.4 4.2e-14 Malaria; CRC trans rs7267979 0.934 rs4815423 chr20:25387521 A/G cg17903999 chr18:56338584 MALT1 0.4 6.69 0.35 9.83e-11 Liver enzyme levels (alkaline phosphatase); CRC cis rs1552244 0.572 rs68013239 chr3:10165711 G/T cg02579736 chr3:10068473 FANCD2;CIDECP 1.01 11.58 0.54 2.98e-26 Alzheimer's disease; CRC cis rs10504229 0.683 rs10504225 chr8:58145121 A/T cg04204079 chr8:58130323 NA -0.45 -5.84 -0.31 1.28e-8 Developmental language disorder (linguistic errors); CRC cis rs2153535 0.580 rs1335637 chr6:8465101 A/G cg21535247 chr6:8435926 SLC35B3 0.49 7.4 0.38 1.14e-12 Motion sickness; CRC cis rs812925 0.533 rs60997156 chr2:61396539 T/A cg10580144 chr2:61372316 C2orf74 0.35 7.81 0.4 7.58e-14 Immature fraction of reticulocytes; CRC cis rs902774 0.585 rs7399070 chr12:53355678 G/T cg14581129 chr12:53358946 NA -0.91 -8.83 -0.44 6.57e-17 Prostate cancer; CRC cis rs4862750 0.872 rs4862748 chr4:187877388 C/T cg11301795 chr4:187892539 NA 0.77 14.09 0.61 1.3e-35 Lobe attachment (rater-scored or self-reported); CRC cis rs13256369 1.000 rs12545771 chr8:8567977 C/G cg06671706 chr8:8559999 CLDN23 0.62 9.14 0.45 6.71e-18 Obesity-related traits; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg26829925 chr15:80216159 C15orf37;ST20 0.47 6.43 0.33 4.43e-10 Anxiety disorder; CRC cis rs2836974 0.932 rs11910151 chr21:40560262 T/C cg11890956 chr21:40555474 PSMG1 1.11 20.66 0.75 2.27e-61 Cognitive function; CRC cis rs875971 0.895 rs1833495 chr7:65921595 T/C cg11764359 chr7:65958608 NA 0.62 9.91 0.48 1.96e-20 Aortic root size; CRC cis rs6662572 0.737 rs6429592 chr1:46472153 G/A cg03123370 chr1:45965343 CCDC163P;MMACHC -0.46 -6.0 -0.31 5.17e-9 Blood protein levels; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg19427701 chr9:140196790 NRARP 0.43 6.1 0.32 3.02e-9 Response to antipsychotic treatment; CRC cis rs4268898 0.662 rs58971404 chr2:24403753 G/A cg06627628 chr2:24431161 ITSN2 -0.86 -11.71 -0.54 1.02e-26 Asthma; CRC cis rs2346160 0.899 rs206977 chr6:167690746 G/C cg27333441 chr6:167680455 NA -0.38 -6.21 -0.32 1.58e-9 Parental extreme longevity (95 years and older); CRC cis rs12410462 0.582 rs12408978 chr1:227596235 A/T cg04117972 chr1:227635322 NA -0.64 -6.85 -0.35 3.7e-11 Major depressive disorder; CRC cis rs6502050 0.871 rs8072702 chr17:80074280 C/T cg09264619 chr17:80180166 NA 0.38 6.28 0.33 1.06e-9 Life satisfaction; CRC cis rs875971 0.825 rs1000464 chr7:65777909 G/C cg00343986 chr7:65444356 GUSB -0.4 -5.7 -0.3 2.61e-8 Aortic root size; CRC cis rs4654899 0.802 rs10493004 chr1:21442736 T/C cg02927042 chr1:21476669 EIF4G3 -0.52 -8.07 -0.41 1.31e-14 Superior frontal gyrus grey matter volume; CRC cis rs7044106 0.718 rs1981021 chr9:123388393 T/G cg09586646 chr9:123605570 PSMD5;LOC253039 0.63 9.51 0.46 4.25e-19 Hip circumference adjusted for BMI; CRC cis rs6500395 0.926 rs9929569 chr16:48677584 C/T cg04672837 chr16:48644449 N4BP1 0.42 6.02 0.31 4.71e-9 Response to tocilizumab in rheumatoid arthritis; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg22371845 chr8:140718096 NA 0.44 6.19 0.32 1.75e-9 Response to antipsychotic treatment; CRC cis rs709400 0.827 rs2274269 chr14:104029246 G/A cg12935359 chr14:103987150 CKB -0.36 -5.64 -0.3 3.58e-8 Body mass index; CRC cis rs2243480 0.908 rs1532573 chr7:65798802 A/G cg12463550 chr7:65579703 CRCP -0.7 -6.28 -0.33 1.08e-9 Diabetic kidney disease; CRC trans rs561341 1.000 rs8073186 chr17:30244956 T/C cg20587970 chr11:113659929 NA -0.96 -13.3 -0.59 1.36e-32 Hip circumference adjusted for BMI; CRC trans rs2172802 0.570 rs2133009 chr4:62516026 T/C cg25787300 chr7:101599518 CUX1 -0.42 -5.97 -0.31 6.22e-9 Partial epilepsies; CRC cis rs7586879 0.593 rs10198275 chr2:25130542 A/C cg04586622 chr2:25135609 ADCY3 -0.54 -10.05 -0.48 6.83e-21 Body mass index; CRC cis rs7804356 1.000 rs3801814 chr7:26881302 T/G cg03456212 chr7:26904342 SKAP2 -0.49 -5.62 -0.3 4.1e-8 Type 1 diabetes; CRC cis rs2108622 0.727 rs2158511 chr19:15986647 C/T cg13772218 chr19:15982569 NA 0.48 6.75 0.35 6.72e-11 Circulating phylloquinone levels;Vitamin E levels;Acenocoumarol maintenance dosage;Response to Vitamin E supplementation;Metabolite levels;Warfarin maintenance dose; CRC cis rs12142240 0.698 rs6659228 chr1:46811027 C/G cg14993813 chr1:46806288 NSUN4 -0.49 -6.1 -0.32 2.92e-9 Menopause (age at onset); CRC cis rs2842992 0.958 rs2758318 chr6:160069637 C/G cg19482086 chr6:160211437 TCP1;MRPL18 0.73 10.05 0.48 6.9299999999999992e-21 Age-related macular degeneration (geographic atrophy); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg14886145 chr10:74451829 CCDC109A 0.46 6.44 0.33 4.25e-10 Response to antipsychotic treatment; CRC cis rs727563 0.635 rs5751141 chr22:42107745 A/G cg06634786 chr22:41940651 POLR3H 0.68 7.58 0.39 3.6e-13 Crohn's disease;Inflammatory bowel disease; CRC cis rs4713118 0.868 rs742047 chr6:27739380 A/G cg12273811 chr6:28175739 NA 0.51 5.71 0.3 2.55e-8 Parkinson's disease; CRC cis rs2439831 1.000 rs527921 chr15:43770416 G/T cg02155558 chr15:43621948 ADAL;LCMT2 -0.7 -8.18 -0.41 6.14e-15 Lung cancer in ever smokers; CRC cis rs11098499 0.779 rs7674500 chr4:120303593 C/T cg24375607 chr4:120327624 NA 0.51 7.86 0.4 5.5e-14 Corneal astigmatism; CRC trans rs7746199 0.668 rs7749305 chr6:27446566 T/C cg06606381 chr12:133084897 FBRSL1 -0.84 -6.75 -0.35 6.61e-11 Gait speed in old age;Autism spectrum disorder or schizophrenia; CRC cis rs7107174 0.892 rs4291702 chr11:78001248 C/T cg02023728 chr11:77925099 USP35 0.46 7.92 0.4 3.66e-14 Testicular germ cell tumor; CRC cis rs524023 0.957 rs538737 chr11:64355772 C/G cg14139581 chr11:64358342 SLC22A12 0.38 6.03 0.32 4.38e-9 Urate levels in obese individuals; CRC cis rs4676380 0.927 rs1583259 chr2:241644934 G/T cg21930842 chr2:241631663 AQP12A 0.42 6.49 0.34 3.16e-10 Response to metformin (IC50); CRC trans rs7937682 0.961 rs1784784 chr11:111483185 C/T cg18187862 chr3:45730750 SACM1L 0.45 6.54 0.34 2.35e-10 Primary sclerosing cholangitis; CRC cis rs3820068 0.559 rs6675334 chr1:15923580 A/T cg13390004 chr1:15929781 NA 0.5 7.06 0.36 9.67e-12 Systolic blood pressure; CRC cis rs651907 0.557 rs62284198 chr3:101474699 G/A cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.63 8.73 0.43 1.3e-16 Colorectal cancer; CRC cis rs881375 0.678 rs1930782 chr9:123687905 C/T cg14255062 chr9:123606675 PSMD5;LOC253039 0.36 5.61 0.3 4.23e-8 Rheumatoid arthritis; CRC cis rs7312933 0.703 rs10880264 chr12:42586535 A/G cg19980929 chr12:42632907 YAF2 0.45 6.6 0.34 1.65e-10 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CRC cis rs4819052 0.851 rs2877018 chr21:46658306 G/A cg02159808 chr21:46707872 POFUT2;LOC642852 0.49 6.41 0.33 5.19e-10 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs1348850 0.914 rs6761593 chr2:178451600 A/G cg02961200 chr2:178257176 LOC100130691;AGPS -0.49 -7.1 -0.36 7.89e-12 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC trans rs801193 1.000 rs3778909 chr7:66255646 G/C cg05627663 chr7:65219948 SNORA22;CCT6P1 0.41 5.97 0.31 6.04e-9 Aortic root size; CRC trans rs2303319 0.504 rs62188988 chr2:162531068 T/C cg22988483 chr14:93581567 ITPK1 -0.68 -6.29 -0.33 1.03e-9 Cognitive function; CRC cis rs9443645 0.869 rs1507154 chr6:79503700 C/T cg05283184 chr6:79620031 NA -0.56 -8.97 -0.44 2.23e-17 Intelligence (multi-trait analysis); CRC cis rs6120849 0.707 rs6088690 chr20:33633326 A/G cg08999081 chr20:33150536 PIGU 0.44 5.73 0.3 2.23e-8 Protein C levels; CRC cis rs9534288 0.671 rs4942465 chr13:46562687 C/T cg15192986 chr13:46630673 CPB2 -0.64 -9.74 -0.47 7.04e-20 Blood protein levels; CRC cis rs4481887 0.790 rs4453078 chr1:248411889 A/G cg00666640 chr1:248458726 OR2T12 -0.47 -8.96 -0.44 2.53e-17 Common traits (Other); CRC cis rs863345 0.604 rs6663277 chr1:158495001 A/T cg12129480 chr1:158549410 OR10X1 -0.29 -5.95 -0.31 6.94e-9 Pneumococcal bacteremia; CRC cis rs634534 0.562 rs1151505 chr11:65734539 C/T cg26695010 chr11:65641043 EFEMP2 -0.4 -6.1 -0.32 2.94e-9 Sum eosinophil basophil counts;Eosinophil counts; CRC cis rs10046574 0.831 rs7780028 chr7:135092556 A/G cg27474649 chr7:135195673 CNOT4 0.69 5.71 0.3 2.58e-8 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs11123170 0.543 rs2166421 chr2:113990242 T/C cg21482265 chr2:113992762 PAX8;LOC440839;LOC654433 0.51 5.74 0.3 2.2e-8 Renal function-related traits (BUN); CRC trans rs7618501 0.635 rs34080578 chr3:50026029 A/C cg21665057 chr3:196295764 WDR53;FBXO45 0.61 9.77 0.47 5.59e-20 Intelligence (multi-trait analysis); CRC cis rs9291683 0.588 rs4697705 chr4:10108127 G/A cg11266682 chr4:10021025 SLC2A9 -0.43 -8.54 -0.43 5.05e-16 Bone mineral density; CRC cis rs7209700 0.889 rs16941801 chr17:45354543 G/C cg08085267 chr17:45401833 C17orf57 0.46 6.53 0.34 2.53e-10 IgG glycosylation; CRC trans rs2012709 0.935 rs11742628 chr5:32563122 T/G cg03755955 chr8:6424269 MCPH1 0.44 6.53 0.34 2.56e-10 Breast cancer; CRC trans rs58106596 0.517 rs17271845 chr2:232653173 G/T cg01370599 chr3:116745421 NA 0.48 6.23 0.32 1.43e-9 White blood cell count;Lymphocyte counts; CRC cis rs7927771 0.832 rs67116452 chr11:47385194 G/A cg05585544 chr11:47624801 NA -0.5 -8.88 -0.44 4.49e-17 Subjective well-being; CRC cis rs9916302 0.904 rs587343 chr17:37440603 C/T cg03013999 chr17:37608204 MED1 -0.47 -7.13 -0.37 6.51e-12 Glomerular filtration rate (creatinine); CRC cis rs1448094 0.512 rs7953318 chr12:86245929 G/A cg02569458 chr12:86230093 RASSF9 0.43 7.41 0.38 1.06e-12 Major depressive disorder; CRC cis rs3617 0.539 rs9985365 chr3:52953844 A/G cg11645453 chr3:52864694 ITIH4 -0.36 -6.76 -0.35 6.3e-11 Red blood cell count;Autism spectrum disorder or schizophrenia; CRC trans rs3733585 0.699 rs6449158 chr4:9960459 T/C cg26043149 chr18:55253948 FECH -0.5 -7.62 -0.39 2.7e-13 Cleft plate (environmental tobacco smoke interaction); CRC cis rs7666738 0.830 rs62321564 chr4:98976496 C/G cg05340658 chr4:99064831 C4orf37 0.6 9.35 0.46 1.41e-18 Colonoscopy-negative controls vs population controls; CRC cis rs2576037 0.583 rs9947131 chr18:44534769 G/T cg07643061 chr18:44555308 TCEB3C;TCEB3CL;KATNAL2 -0.35 -5.78 -0.3 1.72e-8 Personality dimensions; CRC trans rs7615952 0.599 rs67575510 chr3:125742355 C/G cg07211511 chr3:129823064 LOC729375 -0.77 -10.24 -0.49 1.47e-21 Blood pressure (smoking interaction); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg21076935 chr2:10861602 ATP6V1C2 0.37 6.46 0.34 3.72e-10 Liver disease severity in Alagille syndrome; CRC cis rs2535633 0.588 rs2564930 chr3:53017307 T/C cg07507251 chr3:52567010 NT5DC2 -0.39 -5.81 -0.3 1.51e-8 Body mass index; CRC cis rs2228479 0.850 rs17226519 chr16:89839854 T/C cg19635926 chr16:89946313 TCF25 0.62 5.73 0.3 2.3e-8 Skin colour saturation; CRC cis rs1218582 0.772 rs6686873 chr1:154913404 C/G cg24250549 chr1:154909240 PMVK 0.64 10.92 0.52 6.6e-24 Prostate cancer; CRC cis rs72945132 0.882 rs7929271 chr11:70165749 A/G cg00319359 chr11:70116639 PPFIA1 0.67 7.46 0.38 7.95e-13 Coronary artery disease; CRC cis rs713587 0.646 rs34697209 chr2:25127394 A/G cg22495460 chr2:25135724 ADCY3 -0.9 -18.46 -0.71 1.04e-52 Body mass index in non-asthmatics; CRC cis rs644799 0.965 rs1944080 chr11:95503636 T/C cg25478527 chr11:95522999 CEP57;FAM76B 0.52 7.75 0.39 1.15e-13 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs7259376 0.623 rs7252078 chr19:22503015 G/A cg02657401 chr19:22469223 NA -0.3 -6.44 -0.33 4.24e-10 Menopause (age at onset); CRC cis rs1443512 0.755 rs1373160 chr12:54340383 A/G cg17410650 chr12:54324560 NA -0.33 -5.84 -0.31 1.23e-8 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for BMI in non-smokers;Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction);Waist-hip ratio;Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour); CRC cis rs875971 0.522 rs1968127 chr7:66056803 C/T cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.43 -6.32 -0.33 8.44e-10 Aortic root size; CRC trans rs71537559 1 rs71537559 chr6:27309779 G/C cg06606381 chr12:133084897 FBRSL1 -1.24 -8.14 -0.41 8e-15 Squamous cell lung carcinoma; CRC cis rs2836950 0.545 rs2297256 chr21:40558421 C/T cg11644478 chr21:40555479 PSMG1 -0.49 -7.36 -0.38 1.49e-12 Menarche (age at onset); CRC cis rs4973397 0.668 rs4973393 chr2:232289526 G/T cg13347044 chr2:232276743 NA 0.41 5.92 0.31 8.16e-9 Anti-saccade response; CRC cis rs12188164 0.610 rs57433159 chr5:418725 C/T cg26850624 chr5:429559 AHRR -0.68 -10.78 -0.51 2.14e-23 Cystic fibrosis severity; CRC cis rs4332037 0.522 rs4721098 chr7:1881527 G/C cg13880726 chr7:1868755 MAD1L1 0.43 5.77 0.3 1.84e-8 Bipolar disorder; CRC cis rs875971 0.545 rs73378304 chr7:65640747 G/A cg02869306 chr7:64672164 INTS4L1 -0.4 -6.04 -0.32 4.19e-9 Aortic root size; CRC cis rs4964805 0.594 rs3812805 chr12:104170872 C/T cg02344784 chr12:104178138 NT5DC3 0.42 6.15 0.32 2.28e-9 Attention deficit hyperactivity disorder; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg02571725 chr16:1832656 SPSB3;NUBP2 0.48 6.67 0.35 1.06e-10 Response to antipsychotic treatment; CRC cis rs6942756 1.000 rs6467243 chr7:129001508 A/G cg02491457 chr7:128862824 NA -0.61 -8.04 -0.41 1.59e-14 White matter hyperintensity burden; CRC cis rs939584 0.825 rs7579971 chr2:631603 C/T cg03610516 chr2:642275 NA 0.43 5.61 0.3 4.36e-8 Body mass index; CRC trans rs1005277 0.579 rs1780137 chr10:38501475 C/G cg23533926 chr12:111358616 MYL2 -0.55 -8.31 -0.42 2.49e-15 Extrinsic epigenetic age acceleration; CRC cis rs2836974 0.897 rs6517513 chr21:40526878 A/G cg11644478 chr21:40555479 PSMG1 0.82 13.39 0.59 6.26e-33 Cognitive function; CRC cis rs7044106 0.791 rs7043969 chr9:123493989 A/C cg14255062 chr9:123606675 PSMD5;LOC253039 0.5 7.63 0.39 2.59e-13 Hip circumference adjusted for BMI; CRC cis rs12142240 0.698 rs6684274 chr1:46810842 A/G cg14993813 chr1:46806288 NSUN4 0.5 6.46 0.34 3.84e-10 Menopause (age at onset); CRC cis rs9914988 0.887 rs8078402 chr17:27145124 T/A cg07195577 chr17:27052828 TLCD1 0.41 5.92 0.31 7.89e-9 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs9649213 0.593 rs10953255 chr7:97923198 A/G cg00277769 chr7:97922759 BAIAP2L1 -0.62 -10.89 -0.51 8.89e-24 Prostate cancer (SNP x SNP interaction); CRC cis rs483180 0.512 rs612430 chr1:120216025 A/G cg19096424 chr1:120255104 PHGDH 0.46 6.65 0.34 1.2e-10 Macular telangiectasia type 2; CRC cis rs57994353 0.793 rs33982662 chr9:139324737 C/A cg14119001 chr9:139324193 INPP5E -0.51 -7.33 -0.37 1.82e-12 Eosinophil counts;Cutaneous squamous cell carcinoma; CRC cis rs780096 0.526 rs1647267 chr2:27651054 A/T cg02592271 chr2:27665507 KRTCAP3 -0.28 -6.44 -0.33 4.31e-10 Total body bone mineral density; CRC cis rs4713118 0.662 rs149948 chr6:27974817 C/G cg12273811 chr6:28175739 NA 0.62 9.12 0.45 7.46e-18 Parkinson's disease; CRC cis rs6964587 0.967 rs6465341 chr7:91596121 G/C cg17063962 chr7:91808500 NA 0.81 14.21 0.62 4.72e-36 Breast cancer; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg03940137 chr1:200708937 CAMSAP1L1 -0.4 -5.97 -0.31 6.27e-9 Myopia (pathological); CRC cis rs2153535 0.967 rs10484750 chr6:8378609 A/G cg07606381 chr6:8435919 SLC35B3 -0.41 -6.07 -0.32 3.45e-9 Motion sickness; CRC cis rs3733585 0.699 rs4515163 chr4:9959603 C/T cg00071950 chr4:10020882 SLC2A9 -0.54 -9.65 -0.47 1.42e-19 Cleft plate (environmental tobacco smoke interaction); CRC cis rs6951245 1.000 rs77346188 chr7:1114023 C/A cg18402987 chr7:1209562 NA 0.66 7.02 0.36 1.29e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg24686357 chr4:48272266 TEC 0.45 6.37 0.33 6.41e-10 Anxiety disorder; CRC cis rs738321 0.725 rs5756926 chr22:38542613 T/C cg25457927 chr22:38595422 NA -0.3 -5.98 -0.31 5.92e-9 Breast cancer; CRC cis rs9303280 0.806 rs12709365 chr17:38027400 A/G cg17344932 chr17:38183730 MED24;SNORD124 0.36 5.67 0.3 3.13e-8 Self-reported allergy; CRC cis rs12431939 0.857 rs2999383 chr14:51648755 C/T cg23942311 chr14:51606299 NA -0.49 -6.36 -0.33 6.56e-10 Cancer; CRC cis rs2559856 1.000 rs2695296 chr12:102085487 T/C cg12924262 chr12:102091054 CHPT1 0.56 8.28 0.42 3.15e-15 Blood protein levels; CRC cis rs9326248 0.501 rs4938351 chr11:117022352 A/C cg20608306 chr11:116969690 SIK3 0.31 6.3 0.33 9.55e-10 Blood protein levels; CRC cis rs7914558 1.000 rs10786733 chr10:104794947 G/A cg04362960 chr10:104952993 NT5C2 0.61 9.23 0.45 3.27e-18 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs4891159 0.790 rs8087557 chr18:74116848 G/C cg24786174 chr18:74118243 ZNF516 -0.92 -17.58 -0.7 3.08e-49 Longevity; CRC cis rs3749237 0.595 rs1050088 chr3:49570882 C/T cg02487422 chr3:49467188 NICN1 -0.43 -6.99 -0.36 1.52e-11 Resting heart rate; CRC cis rs1545257 0.560 rs7561752 chr2:24643834 A/G cg06627628 chr2:24431161 ITSN2 0.47 6.88 0.35 2.99e-11 Sjögren's syndrome; CRC cis rs8180040 0.966 rs17476234 chr3:47326298 G/A cg02527881 chr3:46936655 PTH1R 0.4 7.18 0.37 4.75e-12 Colorectal cancer; CRC cis rs8180040 0.764 rs11130115 chr3:47181661 C/A cg27129171 chr3:47204927 SETD2 0.68 11.12 0.52 1.36e-24 Colorectal cancer; CRC cis rs7618915 0.532 rs13060675 chr3:52674300 T/G cg05573699 chr3:52720067 GNL3;PBRM1 -0.47 -6.68 -0.35 1.02e-10 Bipolar disorder; CRC cis rs875971 0.545 rs1796217 chr7:66085918 A/G cg03233332 chr7:66118400 NA 0.44 6.11 0.32 2.87e-9 Aortic root size; CRC cis rs2836974 0.897 rs2026267 chr21:40711477 C/A cg17971929 chr21:40555470 PSMG1 0.73 9.9 0.48 2.09e-20 Cognitive function; CRC cis rs644799 0.930 rs631099 chr11:95563482 T/C cg25478527 chr11:95522999 CEP57;FAM76B 0.52 7.86 0.4 5.6e-14 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs13191362 0.935 rs34009353 chr6:163007668 T/G cg06582575 chr6:163149167 PACRG;PARK2 0.71 10.22 0.49 1.72e-21 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC trans rs587242 0.955 rs12739556 chr1:96977901 C/T cg10631902 chr5:14652156 NA 0.4 6.15 0.32 2.26e-9 Body mass index (joint analysis main effects and physical activity interaction);Body mass index in physically inactive individuals;Body mass index; CRC cis rs875971 1.000 rs778706 chr7:65860424 A/G cg18912574 chr7:65842487 NCRNA00174 0.36 6.18 0.32 1.88e-9 Aortic root size; CRC cis rs1448094 0.785 rs7955173 chr12:86447214 G/A cg02569458 chr12:86230093 RASSF9 -0.39 -6.56 -0.34 2.11e-10 Major depressive disorder; CRC cis rs9612 0.948 rs189408 chr19:44268006 T/C cg08581076 chr19:44259116 C19orf61 0.47 5.98 0.31 5.87e-9 Exhaled nitric oxide output; CRC cis rs3617 0.573 rs4687682 chr3:52916939 T/C cg11645453 chr3:52864694 ITIH4 -0.43 -8.45 -0.42 9.54e-16 Red blood cell count;Autism spectrum disorder or schizophrenia; CRC cis rs2239547 0.657 rs6445538 chr3:52874288 T/C cg10802521 chr3:52805072 NEK4 -0.47 -6.3 -0.33 9.4e-10 Schizophrenia; CRC cis rs853679 0.527 rs853693 chr6:28282648 C/T cg21251018 chr6:28226885 NKAPL 0.48 7.85 0.4 5.87e-14 Depression; CRC cis rs3743162 0.553 rs12915656 chr15:85415580 G/C cg11189052 chr15:85197271 WDR73 0.53 7.11 0.37 7.08e-12 Alzheimer's disease (age of onset); CRC cis rs8017423 0.615 rs12586761 chr14:90820897 A/G cg14092571 chr14:90743983 NA 0.39 6.0 0.31 5.22e-9 Mortality in heart failure; CRC cis rs4727027 0.901 rs7794500 chr7:148819519 C/T cg12479418 chr7:148823350 ZNF425;ZNF398 -0.45 -6.11 -0.32 2.76e-9 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC cis rs7572644 0.699 rs2016616 chr2:28134037 A/G cg27432699 chr2:27873401 GPN1 -0.41 -5.66 -0.3 3.38e-8 Response to carboplatin and paclitaxel in ovarian cancer (Caspase 3/7 EC50); CRC cis rs9648716 1.000 rs1267624 chr7:140535764 A/C cg10747023 chr7:140774559 NA 0.44 5.76 0.3 1.94e-8 Type 2 diabetes; CRC cis rs910316 0.763 rs175450 chr14:75590340 G/A cg08847533 chr14:75593920 NEK9 -0.84 -14.69 -0.63 6.5e-38 Height; CRC cis rs754466 0.580 rs2579176 chr10:79529350 A/G cg17075019 chr10:79541650 NA -0.95 -17.71 -0.7 9.35e-50 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs6461049 0.765 rs1476887 chr7:2151633 T/C cg02951883 chr7:2050386 MAD1L1 -0.61 -9.75 -0.47 6.55e-20 Schizophrenia; CRC cis rs7772486 0.686 rs857875 chr6:145980033 T/G cg23711669 chr6:146136114 FBXO30 -0.65 -10.82 -0.51 1.55e-23 Lobe attachment (rater-scored or self-reported); CRC trans rs7618501 0.602 rs2240327 chr3:50113034 C/T cg21659725 chr3:3221576 CRBN 0.62 9.76 0.47 6.41e-20 Intelligence (multi-trait analysis); CRC trans rs7613875 0.578 rs2624822 chr3:50107219 T/C cg21665057 chr3:196295764 WDR53;FBXO45 -0.47 -7.06 -0.36 9.98e-12 Body mass index; CRC trans rs6550704 0.687 rs9865314 chr3:22634337 A/G cg04623168 chr12:112546260 NAA25 -0.44 -6.29 -0.33 9.91e-10 Daytime sleep phenotypes; CRC cis rs6502050 0.723 rs11650633 chr17:80083807 T/C cg09264619 chr17:80180166 NA 0.36 5.98 0.31 5.94e-9 Life satisfaction; CRC cis rs4819052 0.851 rs2877019 chr21:46658647 G/A cg11663144 chr21:46675770 NA -0.83 -14.02 -0.61 2.46e-35 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs11122272 0.735 rs2808604 chr1:231538916 T/C cg06096015 chr1:231504339 EGLN1 0.41 6.17 0.32 1.97e-9 Hemoglobin concentration; CRC cis rs853679 0.517 rs6922063 chr6:28094366 G/A cg02683197 chr6:28174875 NA 0.85 10.69 0.51 4.25e-23 Depression; CRC cis rs10504229 0.683 rs6995355 chr8:58113870 C/T cg24829409 chr8:58192753 C8orf71 -0.54 -7.88 -0.4 4.9e-14 Developmental language disorder (linguistic errors); CRC cis rs1552244 0.938 rs7625049 chr3:10115619 C/T cg18598329 chr3:10140678 FANCD2;C3orf24 -0.89 -12.69 -0.57 2.6e-30 Alzheimer's disease; CRC cis rs7703744 0.597 rs73237297 chr5:118691121 G/T cg23917399 chr5:118691751 TNFAIP8 0.42 5.95 0.31 6.94e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs992157 0.798 rs4996257 chr2:219162836 C/T cg04880052 chr2:219191631 PNKD 0.42 6.84 0.35 3.96e-11 Colorectal cancer; CRC cis rs56114371 0.777 rs200482 chr6:27773904 G/A cg23259851 chr6:27775964 HIST1H2AI;HIST1H2BL 0.67 5.72 0.3 2.33e-8 Breast cancer; CRC cis rs72945132 0.882 rs17160762 chr11:70134766 A/G cg00319359 chr11:70116639 PPFIA1 -0.61 -6.28 -0.33 1.07e-9 Coronary artery disease; CRC cis rs4363385 0.818 rs61811863 chr1:152995721 T/C cg25856811 chr1:152973957 SPRR3 -0.25 -7.1 -0.36 7.84e-12 Inflammatory skin disease; CRC cis rs1799949 1.000 rs35330014 chr17:41212547 C/T cg05368731 chr17:41323189 NBR1 0.67 10.09 0.49 5.05e-21 Menopause (age at onset); CRC cis rs12155623 0.803 rs7011862 chr8:49817333 C/G cg22283653 chr8:49824208 NA 0.39 5.88 0.31 1.02e-8 Sudden cardiac arrest; CRC cis rs7666738 0.830 rs28615340 chr4:98896922 T/C cg17366294 chr4:99064904 C4orf37 0.41 6.69 0.35 9.89e-11 Colonoscopy-negative controls vs population controls; CRC cis rs9549328 0.542 rs36172983 chr13:113616582 T/C cg20742385 chr13:113633654 MCF2L 0.55 9.39 0.46 1.01e-18 Systolic blood pressure; CRC cis rs12541635 0.934 rs62527361 chr8:107021574 T/A cg10147462 chr8:107024639 NA 0.41 6.78 0.35 5.72e-11 Age of smoking initiation; CRC cis rs11122272 0.735 rs2474631 chr1:231541341 T/A cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.58 -8.74 -0.43 1.23e-16 Hemoglobin concentration; CRC cis rs61008539 0.853 rs10950611 chr7:861094 G/T cg00934597 chr7:893267 UNC84A -0.57 -7.9 -0.4 4.14e-14 Perceived unattractiveness to mosquitoes; CRC cis rs7224685 0.501 rs6502770 chr17:4007314 A/G cg05562828 chr17:3906858 NA 0.57 10.01 0.48 8.84e-21 Type 2 diabetes; CRC cis rs2115630 1.000 rs4633690 chr15:85361960 C/T cg12501888 chr15:85177176 SCAND2 -0.36 -5.97 -0.31 6.29e-9 P wave terminal force; CRC cis rs6456156 0.586 rs2001114 chr6:167486578 A/G cg23791538 chr6:167370224 RNASET2 -0.39 -5.81 -0.3 1.5e-8 Primary biliary cholangitis; CRC cis rs473651 0.503 rs515342 chr2:239367296 A/G cg21699342 chr2:239360505 ASB1 -0.47 -6.32 -0.33 8.68e-10 Multiple system atrophy; CRC cis rs9322193 0.923 rs57012784 chr6:149948827 G/A cg07701084 chr6:150067640 NUP43 0.55 8.04 0.41 1.61e-14 Lung cancer; CRC cis rs951366 0.789 rs864783 chr1:205711974 T/C cg23034840 chr1:205782522 SLC41A1 0.47 6.4 0.33 5.37e-10 Menarche (age at onset); CRC trans rs1814175 0.645 rs1721995 chr11:49915488 A/G cg11707556 chr5:10655725 ANKRD33B -0.51 -9.64 -0.47 1.6e-19 Height; CRC cis rs2421770 0.530 rs3858470 chr11:35365444 T/C cg13971030 chr11:35366721 SLC1A2 -0.38 -6.67 -0.35 1.08e-10 Staphylococcus aureus nasal carriage (persistent); CRC cis rs9649213 0.593 rs13307593 chr7:97986146 A/G cg24562669 chr7:97807699 LMTK2 0.44 7.27 0.37 2.71e-12 Prostate cancer (SNP x SNP interaction); CRC cis rs4481887 0.927 rs4534422 chr1:248479482 A/G cg13385794 chr1:248469461 NA 0.39 6.74 0.35 7.22e-11 Common traits (Other); CRC cis rs11229555 0.645 rs11560908 chr11:58434545 A/C cg15696309 chr11:58395628 NA 0.84 8.83 0.44 6.28e-17 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; CRC cis rs2404602 0.647 rs12905181 chr15:77098431 A/G cg23625390 chr15:77176239 SCAPER -0.85 -13.64 -0.6 7.19e-34 Blood metabolite levels; CRC cis rs13253111 0.624 rs35990565 chr8:28107815 C/T cg26534493 chr8:28060551 NA 0.45 7.74 0.39 1.21e-13 Childhood body mass index; CRC cis rs7843479 0.601 rs2002941 chr8:21834366 A/C cg17168535 chr8:21777572 XPO7 0.62 10.55 0.5 1.35e-22 Mean corpuscular volume; CRC cis rs9381040 0.655 rs7775972 chr6:41038116 A/C cg09580153 chr6:41068724 NFYA;LOC221442 -0.44 -6.28 -0.33 1.08e-9 Alzheimer's disease (late onset); CRC cis rs12291225 0.679 rs11023170 chr11:14294909 A/G cg19336497 chr11:14380999 RRAS2 -0.51 -8.53 -0.43 5.24e-16 Sense of smell; CRC cis rs1997103 1.000 rs6949244 chr7:55411301 C/G cg17469321 chr7:55412551 NA 0.72 11.28 0.53 3.48e-25 QRS interval (sulfonylurea treatment interaction); CRC cis rs2637266 0.538 rs4379767 chr10:78472596 G/A cg18941641 chr10:78392320 NA -0.35 -5.85 -0.31 1.16e-8 Pulmonary function; CRC cis rs3820068 0.705 rs4646022 chr1:15839112 G/A cg27534772 chr1:16042836 PLEKHM2 0.42 7.09 0.36 8.14e-12 Systolic blood pressure; CRC cis rs7618915 0.501 rs7622694 chr3:52663882 G/A cg10802521 chr3:52805072 NEK4 -0.56 -8.9 -0.44 3.79e-17 Bipolar disorder; CRC trans rs7623430 0.598 rs6550406 chr3:36218075 A/T cg16587794 chr15:69706675 KIF23 -0.43 -6.34 -0.33 7.65e-10 Response to abacavir-containing treatment in HIV-1 infection (virologic failure); CRC cis rs4713118 0.629 rs203889 chr6:28021775 T/G cg03623178 chr6:28175578 NA 0.9 13.0 0.58 1.81e-31 Parkinson's disease; CRC cis rs13108904 0.935 rs1620928 chr4:1279124 C/T cg23123621 chr4:1343375 KIAA1530 -0.33 -5.91 -0.31 8.56e-9 Obesity-related traits; CRC cis rs807669 0.934 rs1780643 chr22:19191725 T/C cg02655711 chr22:19163373 SLC25A1 0.99 20.81 0.75 5.84e-62 Metabolite levels; CRC cis rs1552244 1.000 rs9827740 chr3:10120531 T/C cg16606324 chr3:10149918 C3orf24 0.7 9.74 0.47 7.03e-20 Alzheimer's disease; CRC cis rs2239547 0.522 rs6768844 chr3:53004620 A/G cg11645453 chr3:52864694 ITIH4 -0.52 -9.36 -0.46 1.28e-18 Schizophrenia; CRC cis rs875971 0.545 rs73142233 chr7:65686280 T/A cg05627663 chr7:65219948 SNORA22;CCT6P1 0.63 8.19 0.41 5.86e-15 Aortic root size; CRC cis rs9747201 0.832 rs4072580 chr17:80160337 A/C cg14673194 chr17:80132900 CCDC57 -0.51 -6.74 -0.35 7.09e-11 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs2252521 0.643 rs4141275 chr7:29079870 C/T cg11728747 chr7:29037910 CPVL -0.33 -5.95 -0.31 6.85e-9 Cognitive performance; CRC cis rs7666738 0.830 rs7657490 chr4:99043973 C/T cg17366294 chr4:99064904 C4orf37 0.45 7.73 0.39 1.34e-13 Colonoscopy-negative controls vs population controls; CRC cis rs9325144 0.560 rs11182930 chr12:38633693 A/T cg13010199 chr12:38710504 ALG10B -0.42 -6.08 -0.32 3.27e-9 Morning vs. evening chronotype; CRC cis rs9837602 0.938 rs1017968 chr3:99787011 T/C cg07805332 chr3:99536008 MIR548G;C3orf26 -0.46 -6.02 -0.31 4.7e-9 Breast cancer; CRC cis rs2153535 0.580 rs6905242 chr6:8471799 A/C cg21535247 chr6:8435926 SLC35B3 0.5 7.64 0.39 2.33e-13 Motion sickness; CRC trans rs11673344 0.528 rs578655 chr19:37410757 A/G cg18947437 chr10:1231002 ADARB2 -0.34 -6.06 -0.32 3.74e-9 Obesity-related traits; CRC cis rs72717009 0.825 rs61802846 chr1:161473873 A/C cg15358701 chr1:161410459 NA -0.65 -6.88 -0.35 2.96e-11 Rheumatoid arthritis; CRC cis rs9898058 0.769 rs12150425 chr17:47913932 C/T cg06375292 chr17:47786311 SLC35B1 -0.74 -5.65 -0.3 3.45e-8 Milk allergy; CRC cis rs644799 0.526 rs568120 chr11:95578734 C/T cg25622487 chr11:95524042 FAM76B;CEP57 0.58 8.76 0.44 1.02e-16 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs9399135 0.967 rs9389254 chr6:135330709 C/T cg24558204 chr6:135376177 HBS1L 0.51 8.12 0.41 9.59e-15 Red blood cell count; CRC cis rs7264396 0.563 rs2425136 chr20:34344782 G/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.46 -6.47 -0.34 3.53e-10 Total cholesterol levels; CRC cis rs6120849 0.754 rs3746436 chr20:33586193 C/T cg08999081 chr20:33150536 PIGU 0.45 5.71 0.3 2.56e-8 Protein C levels; CRC cis rs13108904 0.905 rs11247983 chr4:1281951 C/G cg00684032 chr4:1343700 KIAA1530 0.47 6.87 0.35 3.18e-11 Obesity-related traits; CRC cis rs6952808 0.965 rs4719318 chr7:1887930 G/A cg05279229 chr7:1896384 MAD1L1 -0.36 -5.7 -0.3 2.68e-8 Bipolar disorder and schizophrenia; CRC cis rs7131987 0.650 rs16934135 chr12:29483963 T/G cg09582351 chr12:29534625 ERGIC2 -0.33 -6.97 -0.36 1.7e-11 QT interval; CRC cis rs17270561 0.541 rs17586946 chr6:25939053 C/T cg17691542 chr6:26056736 HIST1H1C 0.95 10.61 0.5 8.2000000000000006e-23 Iron status biomarkers; CRC cis rs9914988 0.943 rs2043032 chr17:27136692 A/G cg07195577 chr17:27052828 TLCD1 0.44 5.73 0.3 2.23e-8 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs9837602 0.938 rs793457 chr3:99518987 G/A cg07805332 chr3:99536008 MIR548G;C3orf26 0.47 6.23 0.32 1.44e-9 Breast cancer; CRC cis rs2836950 0.565 rs8134214 chr21:40542367 A/C cg06238570 chr21:40685208 BRWD1 -0.63 -9.24 -0.45 3.09e-18 Menarche (age at onset); CRC trans rs60843830 1.000 rs56321614 chr2:268191 G/T cg11347411 chr7:150020925 ACTR3C;LRRC61 0.56 8.76 0.43 1.09e-16 Spherical equivalent (joint analysis main effects and education interaction); CRC cis rs909002 0.800 rs1061770 chr1:32096265 A/G cg01639898 chr1:32083012 HCRTR1 0.32 6.71 0.35 8.62e-11 Intelligence (multi-trait analysis); CRC cis rs2004318 1.000 rs4097296 chr19:55141019 G/A cg03320607 chr19:54800032 LILRA3 -0.75 -6.0 -0.31 5.26e-9 Blood protein levels; CRC cis rs3785574 0.886 rs62077504 chr17:61837734 A/G cg06601766 chr17:61851465 DDX42;CCDC47 0.6 8.57 0.43 3.95e-16 Height; CRC trans rs747782 0.528 rs16905753 chr11:48285906 C/T cg27395922 chr11:50257633 LOC441601 0.48 6.28 0.33 1.07e-9 Intraocular pressure; CRC cis rs4243830 0.850 rs4908911 chr1:6599523 C/T cg15205204 chr1:6545172 PLEKHG5 0.4 5.73 0.3 2.26e-8 Body mass index; CRC cis rs1552244 0.882 rs13074282 chr3:10024699 T/G cg18598329 chr3:10140678 FANCD2;C3orf24 -0.81 -10.69 -0.51 4.18e-23 Alzheimer's disease; CRC cis rs7773004 0.905 rs1053860 chr6:26325228 C/T cg13736514 chr6:26305472 NA -0.36 -6.17 -0.32 1.99e-9 Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for body mass index;Waist circumference adjusted for BMI in non-smokers;Waist circumference adjusted for BMI (adjusted for smoking behaviour); CRC cis rs1832871 0.711 rs9459946 chr6:158707957 T/C cg07165851 chr6:158734300 TULP4 0.61 7.64 0.39 2.43e-13 Height; CRC cis rs10504229 1.000 rs57624567 chr8:58176995 T/C cg22535103 chr8:58192502 C8orf71 -0.82 -12.27 -0.56 9.63e-29 Developmental language disorder (linguistic errors); CRC cis rs9814567 0.727 rs7430034 chr3:134342127 C/T cg06109529 chr3:134205091 CEP63;ANAPC13 -0.62 -8.89 -0.44 4.11e-17 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs67340775 0.541 rs169287 chr6:27854760 C/A cg15845792 chr6:28175446 NA 0.83 8.58 0.43 3.7e-16 Lung cancer in ever smokers; CRC cis rs9463078 0.691 rs6928753 chr6:45340070 T/C cg25276700 chr6:44698697 NA 0.25 5.95 0.31 6.81e-9 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; CRC cis rs4144743 1.000 rs7223003 chr17:45324293 G/A cg18085866 chr17:45331354 ITGB3 -0.58 -7.98 -0.4 2.41e-14 Body mass index; CRC cis rs4474465 1.000 rs7950865 chr11:78157401 A/G cg27205649 chr11:78285834 NARS2 -0.44 -5.72 -0.3 2.38e-8 Alzheimer's disease (survival time); CRC cis rs875971 0.862 rs1167399 chr7:65561877 G/A cg12463550 chr7:65579703 CRCP -0.53 -7.55 -0.38 4.32e-13 Aortic root size; CRC cis rs7923609 0.967 rs10761758 chr10:65172747 A/T cg08743896 chr10:65200160 JMJD1C -0.42 -6.06 -0.32 3.74e-9 Educational attainment;Liver enzyme levels (alkaline phosphatase); CRC trans rs2797160 1.000 rs1739348 chr6:126014573 T/C cg05039488 chr6:79577232 IRAK1BP1 0.51 7.59 0.39 3.37e-13 Endometrial cancer; CRC cis rs9513593 1.000 rs1964898 chr13:99997181 A/G cg21788972 chr13:99853209 UBAC2 0.46 6.01 0.31 4.91e-9 Psoriasis; CRC cis rs7552404 1.000 rs7552404 chr1:76135946 A/G cg22875332 chr1:76189707 ACADM 0.67 9.14 0.45 6.56e-18 Blood metabolite levels;Acylcarnitine levels; CRC cis rs9911578 1.000 rs6503866 chr17:56619581 C/T cg12560992 chr17:57184187 TRIM37 -0.91 -17.13 -0.69 1.81e-47 Intelligence (multi-trait analysis); CRC cis rs9925964 0.933 rs12448321 chr16:31048280 C/T cg02466173 chr16:30829666 NA 0.44 5.94 0.31 7.14e-9 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs1799949 1.000 rs8176242 chr17:41217874 C/T cg19454999 chr17:41278357 BRCA1;NBR2 0.54 8.24 0.41 4e-15 Menopause (age at onset); CRC cis rs185694 1.000 rs185694 chr13:30885223 C/T cg07600127 chr13:30881527 KATNAL1 0.58 6.56 0.34 2.12e-10 Antineutrophil cytoplasmic antibody-associated vasculitis; CRC cis rs10979 1.000 rs9321923 chr6:143897206 A/G cg25407410 chr6:143891975 LOC285740 -0.84 -13.84 -0.61 1.22e-34 Hypospadias; CRC cis rs6714710 0.603 rs58546246 chr2:98521823 C/A cg26665480 chr2:98280029 ACTR1B 0.53 7.41 0.38 1.08e-12 Posterior cortical atrophy and Alzheimer's disease; CRC trans rs10802346 0.545 rs4607841 chr1:246373295 T/C cg13514129 chr1:39547527 MACF1 0.65 9.78 0.47 5.47e-20 Fractional exhaled nitric oxide (childhood); CRC cis rs9611565 0.512 rs5996063 chr22:42168767 G/A cg06481639 chr22:41940642 POLR3H 0.56 6.24 0.33 1.38e-9 Vitiligo; CRC cis rs28386778 0.863 rs8076760 chr17:61920497 T/C cg11494091 chr17:61959527 GH2 0.6 10.2 0.49 2.03e-21 Prudent dietary pattern; CRC cis rs1451375 0.794 rs11238133 chr7:50542914 A/C cg18232548 chr7:50535776 DDC -0.56 -8.07 -0.41 1.37e-14 Malaria; CRC cis rs1801251 1.000 rs6738386 chr2:233602028 T/C cg25237894 chr2:233734115 C2orf82 0.51 8.33 0.42 2.18e-15 Coronary artery disease; CRC cis rs7258465 0.965 rs7254249 chr19:18591745 G/A cg01065977 chr19:18549689 ISYNA1 -0.41 -6.43 -0.33 4.37e-10 Breast cancer; CRC cis rs7777484 0.534 rs2258709 chr7:2832365 C/T cg09658497 chr7:2847517 GNA12 0.34 5.71 0.3 2.57e-8 Height; CRC cis rs17376456 0.877 rs28418572 chr5:93144161 A/C cg25358565 chr5:93447407 FAM172A 0.99 9.72 0.47 8.19e-20 Diabetic retinopathy; CRC cis rs8141797 0.901 rs2001106 chr22:24535229 A/G cg20894457 chr22:24584366 SUSD2 0.62 8.17 0.41 6.92e-15 Amyotrophic lateral sclerosis;Coronary artery disease; CRC cis rs6089584 0.528 rs4925335 chr20:60627034 G/A cg23463467 chr20:60627584 TAF4 0.44 8.31 0.42 2.47e-15 Body mass index; CRC cis rs1552244 0.882 rs13089863 chr3:10032259 G/T cg08888203 chr3:10149979 C3orf24 -0.58 -7.38 -0.38 1.28e-12 Alzheimer's disease; CRC cis rs875971 0.706 rs1643374 chr7:65872682 T/A cg18876405 chr7:65276391 NA 0.61 10.75 0.51 2.62e-23 Aortic root size; CRC cis rs6701037 0.566 rs729675 chr1:175136946 T/C cg14847009 chr1:175162515 KIAA0040 0.3 6.61 0.34 1.55e-10 Alcohol dependence; CRC trans rs10411161 1.000 rs10402988 chr19:52363104 G/A cg22319618 chr22:45562946 NUP50 -0.52 -6.03 -0.32 4.4e-9 Breast cancer; CRC cis rs17401966 0.838 rs8019 chr1:10366487 T/G cg19773385 chr1:10388646 KIF1B -0.65 -10.38 -0.5 5.1e-22 Hepatocellular carcinoma; CRC cis rs11711311 0.784 rs13081931 chr3:113349928 G/C cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.48 -6.56 -0.34 2.09e-10 IgG glycosylation; CRC cis rs4604732 0.631 rs75600450 chr1:247625492 C/T cg12754571 chr1:247694271 LOC148824;OR2C3 0.42 5.8 0.3 1.57e-8 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CRC cis rs68170813 0.559 rs12535258 chr7:106971050 T/C cg02696742 chr7:106810147 HBP1 -0.58 -6.31 -0.33 8.77e-10 Coronary artery disease; CRC cis rs6545883 0.524 rs2694619 chr2:61536901 C/T cg10580144 chr2:61372316 C2orf74 -0.34 -7.47 -0.38 7.34e-13 Tuberculosis; CRC cis rs1448094 0.512 rs7960130 chr12:86243191 T/C cg02569458 chr12:86230093 RASSF9 0.42 7.24 0.37 3.17e-12 Major depressive disorder; CRC cis rs898097 0.627 rs3785514 chr17:80888905 A/G cg17346650 chr17:80929145 B3GNTL1 0.37 5.82 0.31 1.38e-8 Breast cancer; CRC cis rs3741404 0.620 rs2236647 chr11:63964605 A/G cg19465662 chr11:63993652 NUDT22;TRPT1 -0.64 -9.92 -0.48 1.79e-20 Platelet count; CRC cis rs6942756 0.806 rs10257620 chr7:128901429 C/A cg02491457 chr7:128862824 NA 0.66 9.19 0.45 4.59e-18 White matter hyperintensity burden; CRC cis rs4665809 0.878 rs4665826 chr2:26367503 A/T cg27170947 chr2:26402098 FAM59B 0.5 6.18 0.32 1.85e-9 Gut microbiome composition (summer); CRC cis rs57221529 0.709 rs72707023 chr5:667620 G/A cg16447950 chr5:562315 NA -0.84 -10.57 -0.5 1.15e-22 Lung disease severity in cystic fibrosis; CRC cis rs3106136 0.872 rs10033662 chr4:95239462 G/A cg11021082 chr4:95130006 SMARCAD1 0.45 6.91 0.36 2.46e-11 Capecitabine sensitivity; CRC cis rs801193 1.000 rs2659906 chr7:66165310 T/C cg00343986 chr7:65444356 GUSB 0.49 7.22 0.37 3.53e-12 Aortic root size; CRC cis rs1552244 0.882 rs28366039 chr3:10028988 C/A cg10729496 chr3:10149963 C3orf24 0.5 6.11 0.32 2.82e-9 Alzheimer's disease; CRC cis rs6570726 0.791 rs374478 chr6:145840022 C/T cg13319975 chr6:146136371 FBXO30 -0.44 -6.66 -0.34 1.13e-10 Lobe attachment (rater-scored or self-reported); CRC cis rs17826219 0.706 rs9905827 chr17:29192168 C/A cg13385521 chr17:29058706 SUZ12P 0.68 7.95 0.4 3.09e-14 Body mass index; CRC cis rs4665809 0.590 rs62128457 chr2:26467347 C/A cg27170947 chr2:26402098 FAM59B 0.59 7.71 0.39 1.53e-13 Gut microbiome composition (summer); CRC cis rs524281 0.692 rs2452681 chr11:65814842 G/A cg14036092 chr11:66035641 RAB1B 0.47 6.49 0.34 3.12e-10 Electroencephalogram traits; CRC cis rs62408225 0.963 rs45553631 chr6:90981657 C/T cg06866423 chr6:90926672 BACH2 0.48 7.97 0.4 2.55e-14 Eosinophil counts;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC cis rs9303280 0.776 rs9910826 chr17:38035648 A/G cg11212589 chr17:38028394 ZPBP2 0.43 8.03 0.4 1.71e-14 Self-reported allergy; CRC trans rs1499614 1.000 rs2707832 chr7:66136549 C/T cg10756647 chr7:56101905 PSPH 0.75 8.09 0.41 1.15e-14 Gout; CRC cis rs71403859 0.504 rs12926413 chr16:71972325 T/C cg03805757 chr16:71968109 PKD1L3 -0.66 -5.72 -0.3 2.42e-8 Post bronchodilator FEV1; CRC cis rs2439831 0.850 rs28590651 chr15:44113016 T/C cg02155558 chr15:43621948 ADAL;LCMT2 0.62 7.1 0.36 7.54e-12 Lung cancer in ever smokers; CRC cis rs4499344 0.531 rs259247 chr19:33147657 T/C cg22980127 chr19:33182716 NUDT19 -0.4 -5.61 -0.3 4.27e-8 Mean platelet volume; CRC cis rs11628318 0.614 rs10132160 chr14:103058023 A/G cg23461800 chr14:103021989 NA -0.69 -7.9 -0.4 4.23e-14 Platelet count; CRC trans rs6951245 1.000 rs78185558 chr7:1090183 G/C cg13565492 chr6:43139072 SRF -0.58 -6.05 -0.32 3.96e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs2404602 0.716 rs12902174 chr15:76863540 T/C cg23625390 chr15:77176239 SCAPER 0.47 6.85 0.35 3.61e-11 Blood metabolite levels; CRC cis rs9517320 0.534 rs4772088 chr13:99138270 T/G cg07423050 chr13:99094983 FARP1 -0.55 -7.71 -0.39 1.51e-13 Longevity; CRC cis rs6912958 0.703 rs9353483 chr6:88097180 G/A cg08069147 chr6:88032118 GJB7;C6orf162 0.72 11.43 0.53 1.09e-25 Monocyte percentage of white cells; CRC cis rs2762353 0.595 rs10498728 chr6:25751320 A/T cg15691649 chr6:25882328 NA -0.51 -6.74 -0.35 6.93e-11 Blood metabolite levels; CRC cis rs10256972 0.521 rs7811577 chr7:1102829 C/G cg04025307 chr7:1156635 C7orf50 0.38 5.76 0.3 1.91e-8 Longevity;Endometriosis; CRC cis rs35146811 0.844 rs13223792 chr7:99675659 T/G cg13334819 chr7:99746414 C7orf59 -0.55 -7.52 -0.38 5.24e-13 Coronary artery disease; CRC cis rs453301 0.686 rs28482034 chr8:8869664 G/A cg08975724 chr8:8085496 FLJ10661 -0.39 -5.79 -0.3 1.66e-8 Joint mobility (Beighton score); CRC cis rs17711722 0.675 rs6947132 chr7:65273495 G/A cg11764359 chr7:65958608 NA -0.52 -7.92 -0.4 3.67e-14 Calcium levels; CRC cis rs473651 0.935 rs472357 chr2:239355454 A/G cg08773314 chr2:239334832 ASB1 -0.38 -8.71 -0.43 1.5e-16 Multiple system atrophy; CRC cis rs2429369 0.528 rs2526376 chr17:56427142 A/C cg12560992 chr17:57184187 TRIM37 0.56 8.45 0.42 9.71e-16 Cognitive function; CRC cis rs6693567 0.565 rs12736375 chr1:150411912 T/C cg15654264 chr1:150340011 RPRD2 0.42 6.19 0.32 1.76e-9 Migraine; CRC cis rs1046896 0.514 rs67735447 chr17:80823042 G/T cg19046167 chr17:80928561 B3GNTL1 0.52 7.55 0.38 4.29e-13 Glycated hemoglobin levels; CRC cis rs11212617 1.000 rs624366 chr11:108154097 C/G cg12106634 chr11:108092400 ATM;NPAT -0.41 -6.03 -0.32 4.4e-9 Response to metformin in type 2 diabetes (glycemic); CRC cis rs2814982 0.605 rs75152896 chr6:34477793 G/A cg17674042 chr6:34482479 PACSIN1 -1.01 -11.07 -0.52 2.01e-24 Cholesterol, total;Total cholesterol levels; CRC cis rs9549367 0.789 rs6577034 chr13:113879900 T/C cg18105134 chr13:113819100 PROZ -0.74 -11.67 -0.54 1.41e-26 Platelet distribution width; CRC cis rs7659604 1.000 rs73844281 chr4:122664688 A/G cg20573242 chr4:122745356 CCNA2 0.41 6.14 0.32 2.4e-9 Type 2 diabetes; CRC cis rs13108904 0.967 rs62293658 chr4:1276416 T/C cg02018176 chr4:1364513 KIAA1530 -0.42 -7.28 -0.37 2.52e-12 Obesity-related traits; CRC cis rs12188164 0.965 rs11744539 chr5:451425 C/T cg15813090 chr5:442598 EXOC3;C5orf55 0.39 5.63 0.3 3.9e-8 Cystic fibrosis severity; CRC cis rs10256972 0.552 rs2960837 chr7:1203957 A/G cg18402987 chr7:1209562 NA 0.58 8.92 0.44 3.35e-17 Longevity;Endometriosis; CRC cis rs1267303 0.642 rs11588450 chr1:47000996 C/T cg08533674 chr1:46993347 NA 0.71 9.73 0.47 7.94e-20 Monobrow; CRC cis rs10883723 0.810 rs13287 chr10:104240438 A/G cg22532475 chr10:104410764 TRIM8 -0.34 -6.1 -0.32 2.94e-9 Allergic disease (asthma, hay fever or eczema); CRC cis rs425277 0.606 rs16824792 chr1:2039521 G/T cg24578937 chr1:2090814 PRKCZ -0.39 -7.03 -0.36 1.2e-11 Height; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg18149653 chr12:53267995 NA 0.45 6.43 0.33 4.61e-10 Response to antipsychotic treatment; CRC cis rs6500602 0.527 rs13338333 chr16:4443250 T/C cg14951292 chr16:4525986 HMOX2;NMRAL1 0.62 7.41 0.38 1.05e-12 Schizophrenia; CRC cis rs7584330 0.554 rs13395743 chr2:238437554 C/T cg14458575 chr2:238380390 NA 0.54 6.99 0.36 1.57e-11 Prostate cancer; CRC cis rs270601 0.770 rs10463891 chr5:131597392 C/T cg20512303 chr5:131592959 PDLIM4 -0.43 -8.28 -0.42 3.05e-15 Acylcarnitine levels; CRC cis rs4604732 0.536 rs61184655 chr1:247651342 T/C cg12754571 chr1:247694271 LOC148824;OR2C3 0.39 5.65 0.3 3.5e-8 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CRC cis rs1003719 0.743 rs2835615 chr21:38497303 G/A cg10648535 chr21:38446584 PIGP;TTC3 -0.5 -6.92 -0.36 2.43e-11 Eye color traits; CRC cis rs3785574 0.962 rs4480868 chr17:61788859 C/T cg06601766 chr17:61851465 DDX42;CCDC47 0.56 8.13 0.41 8.78e-15 Height; CRC cis rs4423214 0.840 rs1792231 chr11:71182681 G/A cg05163923 chr11:71159392 DHCR7 -0.63 -7.61 -0.39 2.92e-13 Vitamin D levels; CRC cis rs11122272 0.735 rs2790881 chr1:231534181 A/G cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.58 -8.61 -0.43 2.98e-16 Hemoglobin concentration; CRC cis rs968567 0.638 rs7943728 chr11:61547068 G/A cg00614641 chr11:61596405 FADS2 -0.56 -6.93 -0.36 2.28e-11 Blood metabolite levels;Rheumatoid arthritis;Vitiligo;Glycerophospholipid levels; CRC cis rs2777491 0.872 rs7176588 chr15:41588872 C/T cg18705301 chr15:41695430 NDUFAF1 -0.65 -11.1 -0.52 1.63e-24 Ulcerative colitis; CRC cis rs13191362 0.507 rs2849524 chr6:163127070 C/T cg21926612 chr6:163149169 PACRG;PARK2 -0.63 -9.95 -0.48 1.49e-20 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC trans rs61931739 0.500 rs10772154 chr12:34373271 A/C cg13010199 chr12:38710504 ALG10B 0.45 6.38 0.33 6.15e-10 Morning vs. evening chronotype; CRC cis rs13118159 0.550 rs28614045 chr4:1374695 C/A cg05025164 chr4:1340916 KIAA1530 0.53 7.56 0.38 4.09e-13 Longevity; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg12713848 chr20:35401901 DSN1 0.43 7.12 0.37 6.98e-12 Intelligence (multi-trait analysis); CRC cis rs10504229 0.728 rs17215753 chr8:58153764 A/G cg08219700 chr8:58056026 NA 0.45 5.74 0.3 2.11e-8 Developmental language disorder (linguistic errors); CRC cis rs7727544 0.716 rs72793278 chr5:131561372 C/A cg12564285 chr5:131593104 PDLIM4 0.38 7.18 0.37 4.62e-12 Blood metabolite levels; CRC cis rs1552244 1.000 rs6442146 chr3:10073544 C/T cg08888203 chr3:10149979 C3orf24 0.7 9.92 0.48 1.9e-20 Alzheimer's disease; CRC cis rs1669338 0.588 rs3864049 chr3:3186719 T/G cg16797762 chr3:3221439 CRBN -0.61 -5.68 -0.3 2.93e-8 White matter integrity; CRC cis rs2742417 0.603 rs2673062 chr3:45763635 A/G cg04837898 chr3:45731254 SACM1L -0.48 -7.69 -0.39 1.74e-13 Response to anti-depressant treatment in major depressive disorder; CRC cis rs10206020 0.885 rs11886082 chr2:1576683 T/C cg12573674 chr2:1569213 NA -0.76 -9.71 -0.47 9.16e-20 IgG glycosylation; CRC cis rs7119 0.623 rs11637932 chr15:77847353 T/G cg10437265 chr15:77819839 NA 0.59 9.93 0.48 1.75e-20 Type 2 diabetes; CRC cis rs11098499 0.954 rs2892848 chr4:120381341 C/T cg09307838 chr4:120376055 NA 0.7 10.87 0.51 1.05e-23 Corneal astigmatism; CRC cis rs9309473 0.948 rs13392691 chr2:73748980 G/A cg20560298 chr2:73613845 ALMS1 -0.55 -6.34 -0.33 7.49e-10 Metabolite levels; CRC cis rs6728642 0.803 rs11891458 chr2:97632450 G/T cg26665480 chr2:98280029 ACTR1B -0.5 -5.87 -0.31 1.08e-8 Bipolar disorder lithium response (continuous) or schizophrenia; CRC cis rs832540 0.931 rs2591960 chr5:56238811 A/T cg20203395 chr5:56204925 C5orf35 0.52 7.3 0.37 2.19e-12 Coronary artery disease; CRC cis rs13108904 0.539 rs13135102 chr4:1330983 A/C cg15763984 chr4:1342303 KIAA1530 0.45 6.95 0.36 1.94e-11 Obesity-related traits; CRC cis rs1784581 0.674 rs1784592 chr6:162387365 T/A cg17173639 chr6:162384350 PARK2 -0.74 -12.38 -0.56 3.63e-29 Itch intensity from mosquito bite; CRC cis rs12760731 0.565 rs11583503 chr1:178169663 G/C cg00404053 chr1:178313656 RASAL2 1.05 10.93 0.52 6.36e-24 Obesity-related traits; CRC cis rs72781680 0.611 rs72781699 chr2:24277709 G/A cg20701182 chr2:24300061 SF3B14 0.59 6.79 0.35 5.27e-11 Lymphocyte counts; CRC cis rs7927592 0.913 rs948316 chr11:68309670 G/T cg01657329 chr11:68192670 LRP5 -0.47 -6.72 -0.35 7.81e-11 Total body bone mineral density; CRC cis rs10782582 0.593 rs114421765 chr1:76141802 C/T cg10523679 chr1:76189770 ACADM -0.42 -5.81 -0.3 1.52e-8 Daytime sleep phenotypes; CRC trans rs208520 1.000 rs208521 chr6:66953625 C/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.89 -11.02 -0.52 2.96e-24 Exhaled nitric oxide output; CRC cis rs4727027 0.833 rs2107846 chr7:148832774 G/A cg23583168 chr7:148888333 NA -0.92 -15.95 -0.66 8.15e-43 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC cis rs7666738 0.791 rs4440223 chr4:99044796 G/A cg17366294 chr4:99064904 C4orf37 0.45 7.73 0.39 1.34e-13 Colonoscopy-negative controls vs population controls; CRC cis rs7258465 1.000 rs7252848 chr19:18612351 C/G cg10790698 chr19:18539756 SSBP4 -0.42 -8.03 -0.4 1.79e-14 Breast cancer; CRC cis rs6951245 0.872 rs76713558 chr7:1095866 A/G cg24642844 chr7:1081250 C7orf50 -0.78 -9.44 -0.46 7.23e-19 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs3806843 0.900 rs2563280 chr5:140131530 G/C cg19875535 chr5:140030758 IK -0.53 -8.41 -0.42 1.22e-15 Depressive symptoms (multi-trait analysis); CRC cis rs9399135 0.935 rs11760000 chr6:135370496 G/A cg24558204 chr6:135376177 HBS1L 0.49 7.74 0.39 1.21e-13 Red blood cell count; CRC cis rs644799 1.000 rs586238 chr11:95560371 C/T cg25478527 chr11:95522999 CEP57;FAM76B 0.53 8.05 0.41 1.52e-14 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs4423214 1.000 rs4423214 chr11:71173254 C/T cg05163923 chr11:71159392 DHCR7 0.66 9.34 0.46 1.55e-18 Vitamin D levels; CRC cis rs7727544 0.716 rs11955347 chr5:131567924 G/A cg11843238 chr5:131593191 PDLIM4 0.36 6.69 0.35 9.43e-11 Blood metabolite levels; CRC cis rs6088813 1.000 rs6141546 chr20:33949282 T/C cg14752227 chr20:34000481 UQCC -0.37 -5.82 -0.31 1.39e-8 Height; CRC cis rs1572438 0.759 rs9379144 chr6:846919 C/G cg13447295 chr6:887704 NA 0.48 6.74 0.35 7.31e-11 Aging; CRC cis rs6762 0.642 rs28692469 chr11:839675 T/C cg03116740 chr11:841335 TSPAN4;POLR2L -0.42 -7.1 -0.36 7.51e-12 Mean platelet volume; CRC cis rs2032447 0.802 rs12346 chr6:26097046 T/C cg03517284 chr6:25882590 NA -0.47 -6.41 -0.33 5.18e-10 Intelligence (multi-trait analysis); CRC cis rs28386778 0.897 rs2584640 chr17:61863488 C/T cg07362569 chr17:61921086 SMARCD2 0.39 5.96 0.31 6.34e-9 Prudent dietary pattern; CRC trans rs11165623 0.602 rs4619021 chr1:97025910 T/C cg10631902 chr5:14652156 NA -0.4 -6.87 -0.35 3.29e-11 Hip circumference;Waist circumference; CRC cis rs28386778 0.830 rs2597636 chr17:61876010 A/G cg25654072 chr17:61904446 PSMC5;FTSJ3 0.74 11.5 0.54 6.02e-26 Prudent dietary pattern; CRC trans rs60843830 0.964 rs17713879 chr2:254215 G/A cg11347411 chr7:150020925 ACTR3C;LRRC61 0.59 9.21 0.45 3.97e-18 Spherical equivalent (joint analysis main effects and education interaction); CRC cis rs1448094 0.621 rs10863091 chr12:86282240 T/C cg19622623 chr12:86230825 RASSF9 -0.39 -6.19 -0.32 1.77e-9 Major depressive disorder; CRC cis rs7666738 0.753 rs10029372 chr4:98859002 T/C cg17366294 chr4:99064904 C4orf37 0.4 6.48 0.34 3.45e-10 Colonoscopy-negative controls vs population controls; CRC cis rs2276314 0.857 rs62101376 chr18:33582955 T/C cg19628046 chr18:33552617 C18orf21 0.47 6.2 0.32 1.68e-9 Endometriosis;Drug-induced torsades de pointes; CRC trans rs656319 0.559 rs17689289 chr8:9977980 C/G cg06636001 chr8:8085503 FLJ10661 0.44 6.45 0.34 4.02e-10 Myopia (pathological); CRC cis rs79387448 0.745 rs57942521 chr2:103139849 A/G cg00507830 chr2:103233733 NA 0.54 5.84 0.31 1.27e-8 Gut microbiota (bacterial taxa); CRC cis rs11212617 1.000 rs608086 chr11:108185023 G/A cg01991180 chr11:108092276 ATM;NPAT 0.42 6.2 0.32 1.68e-9 Response to metformin in type 2 diabetes (glycemic); CRC trans rs7615952 0.512 rs11921452 chr3:125359750 A/G cg21747405 chr11:67723411 NA -0.58 -9.13 -0.45 6.88e-18 Blood pressure (smoking interaction); CRC cis rs10751667 0.857 rs6597961 chr11:976677 T/C ch.11.42038R chr11:967971 AP2A2 0.68 11.28 0.53 3.59e-25 Alzheimer's disease (late onset); CRC cis rs6445967 1.000 rs3796215 chr3:58316657 A/G cg23715586 chr3:58305044 RPP14 0.37 6.01 0.31 4.82e-9 Platelet count; CRC cis rs1799949 1.000 rs8176297 chr17:41203325 T/A cg25072359 chr17:41440525 NA 0.45 6.82 0.35 4.26e-11 Menopause (age at onset); CRC cis rs8177179 0.967 rs9869311 chr3:133451613 C/T cg16262614 chr3:133464971 TF 0.5 9.58 0.47 2.47e-19 Iron status biomarkers (transferrin levels); CRC trans rs11039798 0.588 rs589834 chr11:48419382 C/G cg03929089 chr4:120376271 NA -0.64 -7.05 -0.36 1.05e-11 Axial length; CRC cis rs7043114 0.525 rs1053446 chr9:95146761 T/A cg13798575 chr9:95087839 CENPP;NOL8 -0.4 -5.98 -0.31 5.7e-9 Height; CRC trans rs6066835 0.572 rs12329434 chr20:47260191 T/C cg21109867 chr19:55897418 RPL28 -0.83 -6.25 -0.33 1.24e-9 Multiple myeloma; CRC cis rs1577917 0.958 rs2324817 chr6:86462654 A/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.52 -7.11 -0.36 7.42e-12 Response to antipsychotic treatment; CRC cis rs796364 0.906 rs281789 chr2:200780698 T/G cg23649088 chr2:200775458 C2orf69 0.55 5.98 0.31 5.66e-9 Schizophrenia; CRC cis rs6700896 0.931 rs10889569 chr1:66086194 A/T cg04111102 chr1:66153794 NA 0.33 5.95 0.31 6.81e-9 C-reactive protein;Mean corpuscular volume;Mean corpuscular hemoglobin; CRC cis rs8180040 0.726 rs11130110 chr3:47000606 T/C cg27129171 chr3:47204927 SETD2 0.65 10.49 0.5 2.1e-22 Colorectal cancer; CRC trans rs2732480 0.500 rs2732461 chr12:48692802 C/A cg14576681 chr2:42588304 COX7A2L 0.46 5.99 0.31 5.42e-9 Hemoglobin concentration;Red blood cell count;Hematocrit; CRC cis rs6502050 0.731 rs11867299 chr17:80088675 C/A cg09264619 chr17:80180166 NA -0.36 -6.09 -0.32 3.09e-9 Life satisfaction; CRC cis rs9399137 0.507 rs11754021 chr6:135308375 A/G cg24558204 chr6:135376177 HBS1L 0.61 9.22 0.45 3.61e-18 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; CRC cis rs1322512 1.000 rs2758777 chr6:153007467 G/T cg03415253 chr6:152958462 SYNE1 0.4 6.13 0.32 2.49e-9 Tonometry; CRC cis rs12973672 1.000 rs10421599 chr19:35767933 G/A cg12095397 chr19:35769544 USF2 0.43 5.67 0.3 3.1e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs763121 0.853 rs2267394 chr22:39101633 T/C cg06022373 chr22:39101656 GTPBP1 0.82 13.45 0.6 3.74e-33 Menopause (age at onset); CRC cis rs2228479 0.867 rs11646448 chr16:89966357 A/T cg19635926 chr16:89946313 TCF25 0.69 7.3 0.37 2.21e-12 Skin colour saturation; CRC cis rs720844 0.748 rs34671855 chr2:149366385 C/T cg09247360 chr2:149335327 NA -0.56 -5.79 -0.3 1.69e-8 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs2710642 0.962 rs2058567 chr2:63091426 T/C cg17519650 chr2:63277830 OTX1 0.44 6.34 0.33 7.47e-10 LDL cholesterol levels;LDL cholesterol; CRC cis rs7605827 0.897 rs6729018 chr2:15540676 A/G cg19274914 chr2:15703543 NA 0.39 5.93 0.31 7.81e-9 Educational attainment (years of education); CRC cis rs4853012 0.775 rs12465641 chr2:74337715 A/G cg05890377 chr2:74357713 NA -0.66 -10.82 -0.51 1.56e-23 Gestational age at birth (maternal effect); CRC cis rs1801251 1.000 rs12990821 chr2:233617585 C/G cg25237894 chr2:233734115 C2orf82 0.54 8.8 0.44 7.77e-17 Coronary artery disease; CRC cis rs7552404 1.000 rs942270 chr1:76177332 G/A cg03433033 chr1:76189801 ACADM 0.8 10.86 0.51 1.11e-23 Blood metabolite levels;Acylcarnitine levels; CRC cis rs11758351 1.000 rs77961951 chr6:26186075 A/G cg00620190 chr6:26240307 HIST1H4F -0.49 -5.75 -0.3 2.06e-8 Gout;Renal underexcretion gout; CRC cis rs769267 0.965 rs7254230 chr19:19434350 C/T cg20644253 chr19:19431407 KIAA0892;SF4 -0.41 -5.73 -0.3 2.33e-8 Tonsillectomy; CRC cis rs3824867 0.920 rs7111873 chr11:47469439 A/G cg05585544 chr11:47624801 NA -0.4 -6.3 -0.33 9.28e-10 Mean corpuscular hemoglobin; CRC cis rs10504229 0.683 rs16921819 chr8:58107936 G/T cg05313129 chr8:58192883 C8orf71 -0.43 -5.87 -0.31 1.09e-8 Developmental language disorder (linguistic errors); CRC cis rs2243480 1.000 rs7792391 chr7:65773429 A/G cg18252515 chr7:66147081 NA 1.27 14.75 0.63 3.81e-38 Diabetic kidney disease; CRC cis rs9325144 0.624 rs12231544 chr12:38901956 C/T cg26384229 chr12:38710491 ALG10B -0.51 -7.2 -0.37 4.14e-12 Morning vs. evening chronotype; CRC cis rs2251381 0.520 rs873651 chr21:30781848 G/A cg24692254 chr21:30365293 RNF160 0.6 9.1 0.45 9.01e-18 Selective IgA deficiency; CRC cis rs12477438 1.000 rs12477438 chr2:99841085 T/G cg26064155 chr2:99771622 LIPT1;TSGA10 -0.69 -8.39 -0.42 1.45e-15 Chronic sinus infection; CRC cis rs1223397 0.651 rs2458309 chr6:13312086 G/A cg07912922 chr6:13274314 PHACTR1 0.38 6.0 0.31 5.21e-9 Blood pressure; CRC cis rs4964805 0.913 rs12229276 chr12:104204771 G/T cg02344784 chr12:104178138 NT5DC3 -0.51 -7.91 -0.4 3.88e-14 Attention deficit hyperactivity disorder; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg07150314 chr2:27579984 GTF3C2 0.43 6.03 0.32 4.37e-9 Anxiety disorder; CRC cis rs743757 0.697 rs763030 chr3:50528092 G/C cg09545109 chr3:50388910 TUSC4;CYB561D2 0.43 5.73 0.3 2.27e-8 Diastolic blood pressure; CRC cis rs910873 0.505 rs7261964 chr20:33205011 C/T cg08999081 chr20:33150536 PIGU 0.49 5.96 0.31 6.38e-9 Melanoma; CRC cis rs1799949 1.000 rs34942571 chr17:41273379 G/C cg25072359 chr17:41440525 NA 0.43 6.34 0.33 7.37e-10 Menopause (age at onset); CRC cis rs67340775 0.541 rs200979 chr6:27852357 G/A cg15845792 chr6:28175446 NA 0.84 8.59 0.43 3.66e-16 Lung cancer in ever smokers; CRC cis rs932541 0.955 rs6043994 chr20:16457896 G/A cg17003395 chr20:16555519 KIF16B 0.41 5.7 0.3 2.7e-8 Intelligence; CRC cis rs7811142 1.000 rs2406253 chr7:100077273 A/G cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.08 15.27 0.64 3.58e-40 Platelet count; CRC cis rs3091242 0.933 rs61775167 chr1:25780893 A/G cg23205692 chr1:25664452 TMEM50A -0.4 -5.67 -0.3 3.13e-8 Erythrocyte sedimentation rate; CRC cis rs13256369 0.774 rs11777719 chr8:8581038 A/G cg17143192 chr8:8559678 CLDN23 0.44 5.76 0.3 1.96e-8 Obesity-related traits; CRC cis rs12541635 0.966 rs62525734 chr8:106984056 T/C cg10147462 chr8:107024639 NA 0.44 7.23 0.37 3.31e-12 Age of smoking initiation; CRC cis rs7772486 0.754 rs697053 chr6:145989807 T/C cg05347473 chr6:146136440 FBXO30 -0.39 -5.84 -0.31 1.25e-8 Lobe attachment (rater-scored or self-reported); CRC cis rs6951245 1.000 rs76804143 chr7:1082021 C/T cg08132940 chr7:1081526 C7orf50 -0.54 -5.64 -0.3 3.65e-8 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs644799 0.965 rs2508713 chr11:95547927 T/A cg25478527 chr11:95522999 CEP57;FAM76B 0.51 7.67 0.39 1.95e-13 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs10847980 0.590 rs1979237 chr12:123325895 C/T cg25930673 chr12:123319894 HIP1R 0.95 7.26 0.37 2.78e-12 Adiponectin levels; CRC cis rs2180341 1.000 rs9285460 chr6:127640190 A/G cg24812749 chr6:127587940 RNF146 0.95 13.63 0.6 7.53e-34 Breast cancer; CRC cis rs7223966 1.000 rs9912201 chr17:61763208 A/G cg23090583 chr17:61904693 PSMC5;FTSJ3 0.55 6.64 0.34 1.33e-10 Hip circumference adjusted for BMI;Body mass index; CRC trans rs9784649 0.891 rs57762467 chr5:25025700 C/T cg11038491 chr20:34638489 LOC647979 -0.6 -6.73 -0.35 7.62e-11 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs1707322 0.752 rs3811435 chr1:46125790 C/A cg03146154 chr1:46216737 IPP 0.67 9.75 0.47 6.98e-20 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs28386778 0.863 rs894414 chr17:61916384 T/C cg11494091 chr17:61959527 GH2 0.6 10.2 0.49 2.03e-21 Prudent dietary pattern; CRC cis rs2976388 0.609 rs2585145 chr8:143799457 G/A cg22687807 chr8:143858763 LYNX1 0.5 8.8 0.44 8.06e-17 Urinary tract infection frequency; CRC cis rs2932538 0.922 rs12143068 chr1:113138110 A/G cg22162597 chr1:113214053 CAPZA1 0.73 10.58 0.5 1.03e-22 Systolic blood pressure;Diastolic blood pressure;Hypertension;Blood pressure; CRC trans rs916888 0.821 rs70600 chr17:44860021 C/T cg07870213 chr5:140052090 DND1 0.9 10.3 0.49 9.55e-22 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs4713118 0.513 rs156739 chr6:28013410 C/A cg03623178 chr6:28175578 NA 0.77 11.37 0.53 1.66e-25 Parkinson's disease; CRC cis rs2637266 0.600 rs11001823 chr10:78326767 G/A cg18941641 chr10:78392320 NA -0.35 -5.85 -0.31 1.21e-8 Pulmonary function; CRC cis rs10208940 0.920 rs7604110 chr2:68790161 A/G cg12452813 chr2:68675892 NA -0.45 -5.75 -0.3 2.03e-8 Urate levels in lean individuals; CRC cis rs11229555 1.000 rs11603890 chr11:58402251 T/C cg15696309 chr11:58395628 NA -0.95 -13.52 -0.6 1.94e-33 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; CRC cis rs2629540 0.766 rs10794177 chr10:126407409 G/C cg08799069 chr10:126477246 METTL10 0.63 7.98 0.4 2.4e-14 Cocaine dependence; CRC cis rs6460942 0.778 rs76030612 chr7:12462937 C/A cg20607287 chr7:12443886 VWDE -0.59 -7.3 -0.37 2.12e-12 Coronary artery disease; CRC cis rs10493773 0.532 rs12064199 chr1:86187073 A/T cg23216685 chr1:86174607 ZNHIT6 -0.27 -6.61 -0.34 1.58e-10 Urate levels in overweight individuals; CRC cis rs7760949 0.888 rs9296853 chr6:13893945 T/A cg27413430 chr6:13925136 RNF182 0.31 5.66 0.3 3.31e-8 Mean corpuscular hemoglobin concentration; CRC cis rs4243830 0.850 rs7552196 chr1:6590502 G/A cg05709478 chr1:6581295 PLEKHG5 -0.56 -6.74 -0.35 7.28e-11 Body mass index; CRC trans rs7395662 0.591 rs7482521 chr11:48609735 G/A cg03929089 chr4:120376271 NA -0.46 -6.42 -0.33 4.85e-10 HDL cholesterol; CRC cis rs4728142 1.000 rs4728142 chr7:128573967 C/T cg14349538 chr7:128577651 IRF5 -0.42 -6.8 -0.35 4.87e-11 Inflammatory bowel disease;Systemic lupus erythematosus;Ulcerative colitis; CRC cis rs916888 0.610 rs142167 chr17:44795234 C/T cg15921436 chr17:44337874 NA -0.51 -6.33 -0.33 8.15e-10 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs7917772 0.636 rs2253709 chr10:104542745 T/A cg22532475 chr10:104410764 TRIM8 -0.36 -6.02 -0.32 4.65e-9 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC cis rs2836974 0.644 rs719230 chr21:40676307 C/T cg06238570 chr21:40685208 BRWD1 -0.82 -13.19 -0.59 3.59e-32 Cognitive function; CRC cis rs7666738 0.606 rs3846447 chr4:99099907 G/A cg05340658 chr4:99064831 C4orf37 0.5 7.3 0.37 2.13e-12 Colonoscopy-negative controls vs population controls; CRC cis rs10479542 0.896 rs4701131 chr5:178982446 A/G cg26516362 chr5:178986906 RUFY1 0.4 7.42 0.38 1.03e-12 Lung cancer; CRC cis rs62229266 0.740 rs2835233 chr21:37393582 A/G cg12218747 chr21:37451666 NA -0.41 -7.0 -0.36 1.46e-11 Mitral valve prolapse; CRC cis rs2354432 0.607 rs9782976 chr1:146825049 A/G cg25205988 chr1:146714368 CHD1L 0.9 8.96 0.44 2.39e-17 Mitochondrial DNA levels; CRC cis rs861020 1.000 rs630984 chr1:209982293 C/T cg09163369 chr1:210001066 C1orf107 0.54 6.77 0.35 5.77e-11 Orofacial clefts; CRC cis rs8044995 0.563 rs8058517 chr16:68379860 A/G cg05110241 chr16:68378359 PRMT7 0.71 7.28 0.37 2.48e-12 Schizophrenia; CRC cis rs644799 0.562 rs654345 chr11:95581865 T/C cg03916912 chr11:95522834 CEP57;FAM76B 0.68 11.21 0.53 6.21e-25 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs3845702 1.000 rs259808 chr2:180791419 T/G cg23417306 chr2:180868811 CWC22 -0.42 -5.67 -0.3 3.14e-8 Schizophrenia; CRC cis rs9611565 0.527 rs2234053 chr22:41777315 G/T cg06634786 chr22:41940651 POLR3H -0.68 -7.81 -0.4 7.69e-14 Vitiligo; CRC cis rs1552244 0.872 rs115331527 chr3:10154504 G/A cg18598329 chr3:10140678 FANCD2;C3orf24 -0.88 -11.6 -0.54 2.66e-26 Alzheimer's disease; CRC cis rs10256972 0.552 rs7805591 chr7:1210745 A/G cg26608667 chr7:1196370 ZFAND2A 0.45 7.34 0.38 1.67e-12 Longevity;Endometriosis; CRC cis rs7103648 1.000 rs10838705 chr11:47424931 G/A cg20307385 chr11:47447363 PSMC3 0.99 18.11 0.71 2.45e-51 Diastolic blood pressure;Systolic blood pressure; CRC cis rs7849270 1.000 rs9697030 chr9:131920181 T/C cg13538475 chr9:131942899 NA -0.34 -6.34 -0.33 7.58e-10 Blood metabolite ratios; CRC cis rs9420 0.961 rs708228 chr11:57585662 C/T cg23127183 chr11:57508653 C11orf31 -0.53 -7.09 -0.36 8.22e-12 Schizophrenia; CRC trans rs2243480 1.000 rs4718333 chr7:65772758 T/C cg10756647 chr7:56101905 PSPH -0.78 -8.05 -0.41 1.55e-14 Diabetic kidney disease; CRC trans rs2407314 0.639 rs1630897 chr8:4085206 T/G cg02458499 chr8:110280928 NUDCD1 -0.33 -6.11 -0.32 2.88e-9 Insulin resistance/response; CRC cis rs875971 0.522 rs1880556 chr7:65432544 T/C cg00343986 chr7:65444356 GUSB 0.53 8.11 0.41 1.03e-14 Aortic root size; CRC cis rs916888 0.697 rs199516 chr17:44856485 C/T cg15921436 chr17:44337874 NA -0.68 -7.78 -0.39 9.39e-14 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs1218582 0.596 rs11264275 chr1:154825270 G/T cg16680214 chr1:154839983 KCNN3 0.41 7.44 0.38 8.97e-13 Prostate cancer; CRC cis rs7680126 0.596 rs714436 chr4:10314667 A/C cg00071950 chr4:10020882 SLC2A9 -0.49 -6.33 -0.33 7.81e-10 Urate levels in lean individuals;Urate levels in overweight individuals;Urate levels in obese individuals; CRC cis rs4700695 0.545 rs29441 chr5:65509116 G/T cg21114390 chr5:65439923 SFRS12 -0.55 -7.67 -0.39 1.9e-13 Facial morphology (factor 19); CRC cis rs6545883 0.507 rs10169662 chr2:61507936 T/C cg10580144 chr2:61372316 C2orf74 -0.35 -7.82 -0.4 7.06e-14 Tuberculosis; CRC cis rs6952808 0.689 rs79950306 chr7:2022063 C/G cg00106254 chr7:1943704 MAD1L1 -0.51 -7.21 -0.37 3.81e-12 Bipolar disorder and schizophrenia; CRC cis rs4975709 0.610 rs4975705 chr5:1860359 T/C cg12288994 chr5:1860383 NA 0.39 6.87 0.35 3.16e-11 Cardiovascular disease risk factors; CRC cis rs9325144 0.650 rs6582631 chr12:38744135 T/C cg13010199 chr12:38710504 ALG10B 0.42 6.09 0.32 3.07e-9 Morning vs. evening chronotype; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg11998173 chr5:107007752 EFNA5 0.41 6.07 0.32 3.6e-9 Liver disease severity in Alagille syndrome; CRC cis rs9303401 0.612 rs2526370 chr17:56487636 G/C cg12560992 chr17:57184187 TRIM37 0.51 7.66 0.39 2.13e-13 Cognitive test performance; CRC cis rs7072216 0.727 rs7915108 chr10:100164441 T/C cg26618903 chr10:100175079 PYROXD2 -0.49 -7.97 -0.4 2.68e-14 Metabolite levels; CRC cis rs9814567 1.000 rs7611611 chr3:134307877 A/G cg06109529 chr3:134205091 CEP63;ANAPC13 -0.8 -11.7 -0.54 1.13e-26 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs6502050 0.835 rs3935129 chr17:80113381 G/C cg13198984 chr17:80129470 CCDC57 0.46 8.16 0.41 6.94e-15 Life satisfaction; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg10991454 chr2:30834674 LCLAT1 0.29 6.3 0.33 9.71e-10 Liver disease severity in Alagille syndrome; CRC cis rs8005677 1.000 rs4982706 chr14:23381697 C/T cg25600027 chr14:23388339 RBM23 -0.53 -8.37 -0.42 1.65e-15 Cognitive ability (multi-trait analysis); CRC cis rs7258465 1.000 rs34746918 chr19:18539744 C/T cg06462663 chr19:18546047 ISYNA1 0.49 7.15 0.37 5.68e-12 Breast cancer; CRC cis rs12291225 0.679 rs7934671 chr11:14305101 C/T cg19336497 chr11:14380999 RRAS2 -0.52 -8.54 -0.43 5.22e-16 Sense of smell; CRC cis rs35110281 0.807 rs9984002 chr21:45061501 T/C cg01579765 chr21:45077557 HSF2BP -0.39 -7.63 -0.39 2.56e-13 Mean corpuscular volume; CRC cis rs1862618 0.853 rs190414 chr5:56116772 C/A cg20203395 chr5:56204925 C5orf35 -0.66 -7.97 -0.4 2.65e-14 Initial pursuit acceleration; CRC cis rs10504229 1.000 rs34616626 chr8:58184650 C/T cg24829409 chr8:58192753 C8orf71 -0.68 -11.34 -0.53 2.27e-25 Developmental language disorder (linguistic errors); CRC cis rs4737010 0.570 rs7823138 chr8:41644861 C/T cg17182837 chr8:41585554 ANK1 0.53 7.58 0.39 3.54e-13 Lymphocyte counts;High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Reticulocyte count;Reticulocyte fraction of red cells;Mean corpuscular volume;Immature fraction of reticulocytes;Mean corpuscular hemoglobin concentration; CRC cis rs2303759 0.918 rs9749416 chr19:49885005 G/A cg22307029 chr19:49891270 CCDC155 0.66 9.48 0.46 5.32e-19 Multiple sclerosis; CRC cis rs9467711 0.606 rs9393712 chr6:26371000 G/C cg14345882 chr6:26364793 BTN3A2 0.65 5.74 0.3 2.17e-8 Autism spectrum disorder or schizophrenia; CRC cis rs7726839 0.578 rs10080150 chr5:593160 C/T cg04221910 chr5:616842 CEP72 -0.39 -5.8 -0.3 1.59e-8 Obesity-related traits; CRC cis rs1545257 0.550 rs66943245 chr2:24631075 G/A cg06627628 chr2:24431161 ITSN2 -0.46 -6.73 -0.35 7.57e-11 Sjögren's syndrome; CRC cis rs9938149 0.706 rs12711488 chr16:88319421 C/G cg05435882 chr16:88311214 NA -0.46 -6.12 -0.32 2.6e-9 Corneal structure;Central corneal thickness; CRC cis rs3087591 0.592 rs2342054 chr17:29724708 G/A cg24425628 chr17:29625626 OMG;NF1 0.68 12.47 0.57 1.65e-29 Hip circumference; CRC cis rs8060686 0.641 rs12447931 chr16:68179195 C/T cg26727032 chr16:67993705 SLC12A4 -0.55 -6.32 -0.33 8.35e-10 HDL cholesterol;Metabolic syndrome; CRC cis rs9457247 1.000 rs365189 chr6:167384545 G/A cg23791538 chr6:167370224 RNASET2 -0.38 -5.97 -0.31 6.08e-9 Crohn's disease; CRC cis rs4363385 0.510 rs11205182 chr1:153045748 C/T cg25856811 chr1:152973957 SPRR3 -0.21 -5.86 -0.31 1.1e-8 Inflammatory skin disease; CRC cis rs1707322 0.686 rs1250 chr1:46094027 A/G cg03146154 chr1:46216737 IPP 0.68 9.64 0.47 1.51e-19 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs763121 0.853 rs35522482 chr22:39063015 C/A cg06022373 chr22:39101656 GTPBP1 0.8 12.71 0.57 2.19e-30 Menopause (age at onset); CRC cis rs875971 0.964 rs2161065 chr7:65932905 A/G cg00343986 chr7:65444356 GUSB 0.43 6.29 0.33 1.03e-9 Aortic root size; CRC cis rs11997175 0.756 rs4739435 chr8:33818818 A/G ch.8.33884649F chr8:33765107 NA 0.48 6.87 0.35 3.14e-11 Body mass index; CRC cis rs12476592 0.571 rs262475 chr2:63869045 A/T cg10828910 chr2:63850056 LOC388955 0.5 6.25 0.33 1.3e-9 Childhood ear infection; CRC cis rs10504229 0.953 rs116564484 chr8:58172818 T/C cg05313129 chr8:58192883 C8orf71 -0.46 -7.07 -0.36 9.56e-12 Developmental language disorder (linguistic errors); CRC cis rs60843830 0.550 rs300751 chr2:209063 A/C cg00108164 chr2:264199 ACP1;SH3YL1 0.46 6.99 0.36 1.56e-11 Spherical equivalent (joint analysis main effects and education interaction); CRC cis rs6860806 0.507 rs270608 chr5:131648406 C/T cg18758796 chr5:131593413 PDLIM4 0.43 6.8 0.35 4.98e-11 Breast cancer; CRC cis rs7605827 0.897 rs2890488 chr2:15635439 T/A cg19274914 chr2:15703543 NA 0.4 6.05 0.32 4e-9 Educational attainment (years of education); CRC cis rs1552244 0.882 rs6443279 chr3:10053599 C/A cg02579736 chr3:10068473 FANCD2;CIDECP 0.99 12.66 0.57 3.33e-30 Alzheimer's disease; CRC cis rs7224685 0.501 rs11649992 chr17:4026823 A/C cg21851534 chr17:3907994 ZZEF1 -0.37 -6.05 -0.32 3.87e-9 Type 2 diabetes; CRC cis rs12908161 0.959 rs35557864 chr15:85331629 A/G cg17507749 chr15:85114479 UBE2QP1 0.63 8.87 0.44 4.74e-17 Schizophrenia; CRC cis rs1387259 0.723 rs2732488 chr12:48771444 G/A cg21466736 chr12:48725269 NA -0.52 -7.69 -0.39 1.78e-13 Obstructive sleep apnea trait (apnea hypopnea index); CRC cis rs7552404 0.727 rs61770533 chr1:76306490 C/G cg22875332 chr1:76189707 ACADM 0.59 7.69 0.39 1.72e-13 Blood metabolite levels;Acylcarnitine levels; CRC cis rs6502050 0.842 rs7218075 chr17:80076808 C/G cg13198984 chr17:80129470 CCDC57 -0.48 -8.57 -0.43 3.99e-16 Life satisfaction; CRC cis rs9911578 1.000 rs9904879 chr17:56864422 G/A cg05425664 chr17:57184151 TRIM37 -0.48 -7.44 -0.38 8.69e-13 Intelligence (multi-trait analysis); CRC cis rs9733 0.519 rs11800855 chr1:150800995 G/A cg15448220 chr1:150897856 SETDB1 0.44 6.38 0.33 5.94e-10 Tonsillectomy; CRC cis rs875971 0.830 rs587360 chr7:65522698 C/A cg00343986 chr7:65444356 GUSB 0.46 6.73 0.35 7.44e-11 Aortic root size; CRC cis rs7917772 0.636 rs2253709 chr10:104542745 T/A cg11453585 chr10:104263688 ACTR1A;SUFU 0.68 9.62 0.47 1.76e-19 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC cis rs7811142 1.000 rs6979335 chr7:100089860 T/C cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.06 14.21 0.62 4.58e-36 Platelet count; CRC cis rs7635838 0.892 rs9310384 chr3:11491980 A/G cg00170343 chr3:11313890 ATG7 0.44 6.73 0.35 7.62e-11 HDL cholesterol; CRC cis rs478304 0.637 rs11227255 chr11:65454044 C/T cg05805236 chr11:65401703 PCNXL3 -0.41 -6.54 -0.34 2.29e-10 Acne (severe); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg26649394 chr18:32870462 ZNF271;ZNF397OS 0.41 5.99 0.31 5.52e-9 Intelligence (multi-trait analysis); CRC cis rs7824557 0.564 rs12550129 chr8:11233917 C/T cg08071915 chr8:12219732 FAM66A 0.34 6.16 0.32 2.12e-9 Retinal vascular caliber; CRC cis rs951366 0.873 rs823118 chr1:205723572 C/T cg07157834 chr1:205819609 PM20D1 0.46 6.84 0.35 3.83e-11 Menarche (age at onset); CRC cis rs4713118 0.527 rs35949862 chr6:28115367 A/G cg23161317 chr6:28129485 ZNF389 0.53 6.43 0.33 4.52e-10 Parkinson's disease; CRC cis rs11758351 0.660 rs113208674 chr6:26210465 C/G cg01420254 chr6:26195488 NA 0.79 8.84 0.44 6.05e-17 Gout;Renal underexcretion gout; CRC cis rs9467711 0.606 rs9393713 chr6:26373678 C/T cg16898833 chr6:26189333 HIST1H4D 0.76 6.69 0.35 9.36e-11 Autism spectrum disorder or schizophrenia; CRC cis rs2976388 0.566 rs13250661 chr8:143804134 C/T cg15511327 chr8:143859410 LYNX1 -0.43 -7.14 -0.37 5.92e-12 Urinary tract infection frequency; CRC cis rs68170813 0.559 rs76020313 chr7:106877468 A/G cg02696742 chr7:106810147 HBP1 -0.6 -6.5 -0.34 3.05e-10 Coronary artery disease; CRC cis rs6674970 0.627 rs2864700 chr1:151028929 C/T cg11822372 chr1:151115635 SEMA6C 0.43 6.25 0.33 1.3e-9 Childhood ear infection; CRC cis rs1005277 0.579 rs932538 chr10:38381314 T/C cg17219203 chr10:38645113 HSD17B7P2 -0.42 -5.99 -0.31 5.49e-9 Extrinsic epigenetic age acceleration; CRC cis rs769267 0.931 rs2965197 chr19:19470910 C/T cg01262667 chr19:19385393 TM6SF2 -0.37 -6.02 -0.32 4.6e-9 Tonsillectomy; CRC cis rs9467711 0.651 rs7749414 chr6:26074884 G/T cg08501292 chr6:25962987 TRIM38 0.9 8.44 0.42 1.05e-15 Autism spectrum disorder or schizophrenia; CRC cis rs875971 0.862 rs12698521 chr7:65939489 T/C cg12463550 chr7:65579703 CRCP 0.48 6.78 0.35 5.54e-11 Aortic root size; CRC cis rs523522 0.962 rs1050187 chr12:120902111 A/G cg12219531 chr12:120966889 COQ5 -0.7 -9.15 -0.45 6.32e-18 High light scatter reticulocyte count; CRC cis rs6758955 0.929 rs73161277 chr2:10480883 A/G cg15773312 chr2:10472214 HPCAL1 -0.74 -9.56 -0.47 2.91e-19 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; CRC cis rs1163251 0.869 rs487884 chr1:120217330 C/T cg19096424 chr1:120255104 PHGDH 0.46 6.65 0.34 1.2e-10 Blood metabolite levels; CRC cis rs1223397 1.000 rs1223402 chr6:13271640 G/A cg20827128 chr6:13274284 PHACTR1 0.54 6.54 0.34 2.38e-10 Blood pressure; CRC cis rs10504229 0.906 rs7006539 chr8:58178799 A/T cg24829409 chr8:58192753 C8orf71 -0.67 -10.76 -0.51 2.43e-23 Developmental language disorder (linguistic errors); CRC cis rs9311474 0.508 rs12637627 chr3:52619962 G/T cg15147215 chr3:52552868 STAB1 -0.63 -10.96 -0.52 4.88e-24 Electroencephalogram traits; CRC cis rs3761218 1.000 rs3761218 chr20:3776175 A/G cg25011176 chr20:3776985 CDC25B 0.4 5.69 0.3 2.88e-8 Bipolar disorder; CRC trans rs2303319 0.504 rs55840249 chr2:162426849 C/A cg27113153 chr11:123612418 ZNF202 -0.72 -6.16 -0.32 2.06e-9 Cognitive function; CRC cis rs3087591 1.000 rs984125 chr17:29547254 A/G cg24425628 chr17:29625626 OMG;NF1 0.83 15.89 0.66 1.4e-42 Hip circumference; CRC cis rs9649213 0.574 rs34817002 chr7:97887051 G/A cg21770322 chr7:97807741 LMTK2 0.59 9.85 0.48 3.04e-20 Prostate cancer (SNP x SNP interaction); CRC cis rs7224685 0.501 rs781847 chr17:3958194 G/A cg10724054 chr17:3904396 NA -0.46 -7.56 -0.38 4.16e-13 Type 2 diabetes; CRC cis rs9322193 0.923 rs9968911 chr6:149978555 A/T cg00933542 chr6:150070202 PCMT1 0.31 6.46 0.34 3.81e-10 Lung cancer; CRC cis rs68170813 0.559 rs17427849 chr7:106864237 A/G cg02696742 chr7:106810147 HBP1 -0.63 -7.08 -0.36 8.79e-12 Coronary artery disease; CRC cis rs4631830 0.900 rs10763534 chr10:51534920 C/T cg16070123 chr10:51489643 NA -0.33 -5.61 -0.3 4.26e-8 Prostate-specific antigen levels; CRC cis rs9491140 0.539 rs10872283 chr6:124685919 G/A cg22366943 chr6:124882293 NKAIN2 0.56 8.38 0.42 1.57e-15 Neuroticism; CRC cis rs898097 0.812 rs56405605 chr17:80843663 T/C cg15369054 chr17:80825471 TBCD 0.55 8.9 0.44 3.74e-17 Breast cancer; CRC cis rs4862750 0.872 rs56389997 chr4:187894796 A/C cg11301795 chr4:187892539 NA -0.87 -19.92 -0.74 1.77e-58 Lobe attachment (rater-scored or self-reported); CRC cis rs5753618 0.583 rs5749268 chr22:31809152 G/A cg07713946 chr22:31675144 LIMK2 0.42 6.29 0.33 1.02e-9 Colorectal cancer; CRC cis rs7586879 0.964 rs13412941 chr2:25102709 C/T cg04586622 chr2:25135609 ADCY3 -0.58 -9.98 -0.48 1.12e-20 Body mass index; CRC cis rs807669 0.548 rs9605957 chr22:19187375 G/A cg02655711 chr22:19163373 SLC25A1 0.64 11.08 0.52 1.91e-24 Metabolite levels; CRC cis rs1552244 1.000 rs113771705 chr3:10075983 T/C cg00166722 chr3:10149974 C3orf24 0.71 9.49 0.46 4.86e-19 Alzheimer's disease; CRC cis rs7772486 0.875 rs2748501 chr6:146312258 G/A cg23711669 chr6:146136114 FBXO30 0.68 11.47 0.53 7.33e-26 Lobe attachment (rater-scored or self-reported); CRC cis rs7223966 0.960 rs113155878 chr17:61706560 C/A cg05941027 chr17:61774174 LIMD2 0.33 5.74 0.3 2.17e-8 Hip circumference adjusted for BMI;Body mass index; CRC cis rs1873147 0.569 rs59418037 chr15:63310871 A/G cg12160578 chr15:63334699 TPM1 0.63 7.53 0.38 5.02e-13 Orofacial clefts; CRC cis rs12824058 0.831 rs11060826 chr12:130809931 G/C cg26677194 chr12:130822605 PIWIL1 0.45 7.19 0.37 4.42e-12 Menopause (age at onset); CRC cis rs1506636 0.854 rs6466879 chr7:123276197 G/A cg03229431 chr7:123269106 ASB15 -0.82 -13.36 -0.59 7.68e-33 Plateletcrit;Platelet count; CRC cis rs1799949 1.000 rs2070834 chr17:41242285 T/G cg23758822 chr17:41437982 NA 0.81 13.6 0.6 9.97e-34 Menopause (age at onset); CRC cis rs72717009 0.825 rs6671753 chr1:161478708 G/A cg23840854 chr1:161414152 NA -0.67 -8.14 -0.41 8.07e-15 Rheumatoid arthritis; CRC cis rs7584330 0.554 rs76408976 chr2:238384784 C/T cg14458575 chr2:238380390 NA 0.89 11.18 0.52 8.18e-25 Prostate cancer; CRC cis rs6964587 0.933 rs6465350 chr7:91768615 G/A cg17063962 chr7:91808500 NA 0.83 14.5 0.62 3.6e-37 Breast cancer; CRC cis rs12922317 0.556 rs8062691 chr16:12091829 A/G cg02368508 chr16:12060182 TNFRSF17 -0.5 -8.41 -0.42 1.23e-15 Schizophrenia; CRC cis rs2576037 0.583 rs9954336 chr18:44465945 A/G cg23996704 chr18:44553084 KATNAL2 -0.34 -6.93 -0.36 2.22e-11 Personality dimensions; CRC cis rs4711350 0.862 rs652049 chr6:33711420 C/T cg07979401 chr6:33739406 LEMD2 0.48 5.95 0.31 6.77e-9 Schizophrenia; CRC cis rs6728642 0.908 rs7588921 chr2:98021001 C/T cg26665480 chr2:98280029 ACTR1B -0.55 -6.15 -0.32 2.3e-9 Bipolar disorder lithium response (continuous) or schizophrenia; CRC cis rs4147929 0.532 rs4147932 chr19:1064485 C/T cg26576206 chr19:1064938 ABCA7 0.43 6.33 0.33 8e-10 Alzheimer's disease (late onset); CRC cis rs896854 0.654 rs4735337 chr8:95973465 T/C cg13393036 chr8:95962371 TP53INP1 -0.54 -9.27 -0.46 2.49e-18 Type 2 diabetes; CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg24057176 chr19:1275466 C19orf24 0.38 6.04 0.32 4.28e-9 Obesity-related traits; CRC cis rs6502050 0.835 rs7503111 chr17:80101587 A/T cg02741985 chr17:80059408 CCDC57 0.43 7.15 0.37 5.66e-12 Life satisfaction; CRC cis rs4268898 0.662 rs2303296 chr2:24432839 A/G cg06627628 chr2:24431161 ITSN2 -0.85 -11.58 -0.54 3.01e-26 Asthma; CRC cis rs4713118 0.824 rs9366702 chr6:27734470 T/C cg19041857 chr6:27730383 NA -0.47 -6.51 -0.34 2.77e-10 Parkinson's disease; CRC cis rs9916302 0.861 rs12150493 chr17:37586154 T/C cg07936489 chr17:37558343 FBXL20 -0.85 -13.38 -0.59 6.93e-33 Glomerular filtration rate (creatinine); CRC cis rs7833790 0.660 rs67666182 chr8:82772037 A/G cg27398817 chr8:82754497 SNX16 0.43 5.95 0.31 6.84e-9 Diastolic blood pressure; CRC cis rs9457247 0.534 rs1130033 chr6:167385623 C/T cg23791538 chr6:167370224 RNASET2 -0.5 -8.05 -0.41 1.51e-14 Crohn's disease; CRC cis rs172166 0.516 rs2021826 chr6:28132756 G/A cg03623178 chr6:28175578 NA 0.66 10.08 0.49 5.38e-21 Cardiac Troponin-T levels; CRC cis rs612683 0.517 rs3767832 chr1:100943100 A/G cg06223162 chr1:101003688 GPR88 -0.37 -6.49 -0.34 3.12e-10 Breast cancer; CRC cis rs1552244 1.000 rs17032283 chr3:10081545 C/G cg13047869 chr3:10149882 C3orf24 0.55 7.52 0.38 5.16e-13 Alzheimer's disease; CRC cis rs8180040 0.676 rs13098228 chr3:47138253 A/G cg02527881 chr3:46936655 PTH1R -0.37 -6.8 -0.35 5.02e-11 Colorectal cancer; CRC cis rs12682352 0.602 rs28399241 chr8:8663215 C/T cg06636001 chr8:8085503 FLJ10661 0.52 8.1 0.41 1.08e-14 Neuroticism; CRC cis rs4563143 0.514 rs73029076 chr19:29292032 G/T cg14983838 chr19:29218262 NA 0.52 6.94 0.36 2.03e-11 Methadone dose in opioid dependence; CRC cis rs6754311 0.638 rs1011361 chr2:136553639 G/A cg15123519 chr2:136567270 LCT 0.31 5.83 0.31 1.36e-8 Mosquito bite size; CRC cis rs245880 0.740 rs245888 chr7:29190414 C/T cg17163760 chr7:29186267 CPVL -0.39 -6.73 -0.35 7.63e-11 Warfarin maintenance dose; CRC cis rs4713118 0.869 rs6456802 chr6:27698355 A/G cg06470822 chr6:28175283 NA 0.71 10.07 0.49 5.85e-21 Parkinson's disease; CRC cis rs896854 0.608 rs6991067 chr8:95875676 A/G cg23172400 chr8:95962367 TP53INP1 -0.43 -7.09 -0.36 8.29e-12 Type 2 diabetes; CRC cis rs1801251 0.778 rs2592116 chr2:233735709 G/A cg25237894 chr2:233734115 C2orf82 -0.63 -11.02 -0.52 2.9e-24 Coronary artery disease; CRC trans rs4650994 0.525 rs4650997 chr1:178530744 T/A cg05059571 chr16:84539110 KIAA1609 -0.58 -8.09 -0.41 1.18e-14 HDL cholesterol levels;HDL cholesterol; CRC cis rs7532866 0.885 rs7517224 chr1:26731029 A/G cg17456097 chr1:26900765 RPS6KA1 -0.4 -6.01 -0.31 5.04e-9 Height; CRC cis rs17826219 0.568 rs9898097 chr17:29072672 T/G cg01831904 chr17:28903510 LRRC37B2 -0.62 -6.39 -0.33 5.8e-10 Body mass index; CRC cis rs9534288 0.830 rs1126364 chr13:46633394 C/G cg15192986 chr13:46630673 CPB2 -0.78 -10.96 -0.52 5.02e-24 Blood protein levels; CRC cis rs2806561 0.695 rs67238799 chr1:23335012 G/A cg12483005 chr1:23474871 LUZP1 0.44 6.33 0.33 7.98e-10 Height; CRC cis rs870825 0.929 rs72689273 chr4:185592750 C/T cg04058563 chr4:185651563 MLF1IP 0.63 6.65 0.34 1.2e-10 Blood protein levels; CRC cis rs4731207 0.967 rs3807544 chr7:124400705 G/A cg23710748 chr7:124431027 NA 0.39 6.27 0.33 1.16e-9 Cutaneous malignant melanoma; CRC cis rs7618915 0.571 rs34954168 chr3:52612159 C/T cg18099408 chr3:52552593 STAB1 -0.44 -7.36 -0.38 1.52e-12 Bipolar disorder; CRC cis rs1475911 1.000 rs1475911 chr21:43513480 A/C cg14562523 chr21:43528734 C21orf128;UMODL1 -0.47 -6.55 -0.34 2.21e-10 IgG glycosylation; CRC cis rs16852403 0.507 rs451341 chr1:178097515 G/A cg00404053 chr1:178313656 RASAL2 -0.41 -5.66 -0.3 3.32e-8 Childhood ear infection; CRC cis rs6840360 1.000 rs12502055 chr4:152596668 G/A cg09659197 chr4:152720779 NA 0.52 11.24 0.53 4.87e-25 Intelligence (multi-trait analysis); CRC cis rs1552244 1.000 rs66797209 chr3:10078526 G/A cg00166722 chr3:10149974 C3orf24 0.71 9.49 0.46 4.86e-19 Alzheimer's disease; CRC cis rs2836974 0.931 rs8132285 chr21:40655752 T/C cg17971929 chr21:40555470 PSMG1 0.83 11.88 0.55 2.57e-27 Cognitive function; CRC trans rs2243480 0.711 rs2460426 chr7:65623129 A/G cg10756647 chr7:56101905 PSPH -0.76 -7.96 -0.4 2.77e-14 Diabetic kidney disease; CRC cis rs11161851 0.609 rs1327093 chr1:75369429 C/T cg11196437 chr1:75593865 LHX8 -0.27 -5.61 -0.3 4.29e-8 Visceral fat; CRC cis rs7923609 0.846 rs10740116 chr10:65094992 T/C cg08743896 chr10:65200160 JMJD1C -0.4 -5.77 -0.3 1.81e-8 Educational attainment;Liver enzyme levels (alkaline phosphatase); CRC cis rs1008375 0.966 rs1476836 chr4:17585014 G/C cg02297831 chr4:17616191 MED28 0.45 5.82 0.31 1.41e-8 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs7572644 0.640 rs9678430 chr2:28057129 G/C cg27432699 chr2:27873401 GPN1 0.45 6.11 0.32 2.79e-9 Response to carboplatin and paclitaxel in ovarian cancer (Caspase 3/7 EC50); CRC cis rs10992471 0.603 rs12336415 chr9:95195458 G/T cg14631576 chr9:95140430 CENPP -0.41 -7.24 -0.37 3.14e-12 Visceral adipose tissue/subcutaneous adipose tissue ratio; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg20447654 chr14:45366388 C14orf28 0.43 6.1 0.32 2.95e-9 Response to antipsychotic treatment; CRC cis rs67311347 1.000 rs7612015 chr3:40399974 A/C cg24209194 chr3:40518798 ZNF619 0.42 6.51 0.34 2.74e-10 Renal cell carcinoma; CRC cis rs225245 0.755 rs8078905 chr17:34009029 T/C cg05299278 chr17:33885742 SLFN14 0.5 8.14 0.41 8.31e-15 Reticulocyte count;Reticulocyte fraction of red cells;High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells; CRC cis rs6502050 0.835 rs56095560 chr17:80151304 C/T cg22110888 chr17:80059540 CCDC57 0.4 6.24 0.33 1.33e-9 Life satisfaction; CRC cis rs868036 1.000 rs8037262 chr15:68108572 C/T cg05925327 chr15:68127851 NA -0.3 -5.88 -0.31 9.87e-9 Restless legs syndrome; CRC cis rs4648845 0.579 rs4592207 chr1:2369498 A/G cg07700843 chr1:2391317 NA -0.39 -6.33 -0.33 7.88e-10 Schizophrenia; CRC cis rs62158211 0.955 rs7556815 chr2:114085785 G/A cg17784749 chr2:114082611 LOC440839 0.54 6.33 0.33 8.14e-10 Sleep duration (oversleepers vs undersleepers);Sleep traits (multi-trait analysis);Sleep duration; CRC cis rs881375 0.967 rs2239658 chr9:123671837 A/G cg09586646 chr9:123605570 PSMD5;LOC253039 0.48 6.69 0.35 9.83e-11 Rheumatoid arthritis; CRC cis rs7605827 0.930 rs6431707 chr2:15638165 A/T cg19274914 chr2:15703543 NA 0.39 5.96 0.31 6.59e-9 Educational attainment (years of education); CRC cis rs875971 0.545 rs2420456 chr7:65745606 T/G cg18876405 chr7:65276391 NA 0.46 6.46 0.34 3.85e-10 Aortic root size; CRC cis rs7617773 0.780 rs3731550 chr3:48206583 A/C cg11946769 chr3:48343235 NME6 0.73 9.9 0.48 2.21e-20 Coronary artery disease; CRC cis rs11724804 0.532 rs7657611 chr4:880558 G/C cg08222618 chr4:941054 TMEM175 0.72 12.65 0.57 3.74e-30 Primary biliary cholangitis;Limited cutaneous systemic scleroderma; CRC cis rs9768139 0.733 rs921617 chr7:158118198 A/G cg25566285 chr7:158114605 PTPRN2 0.47 7.5 0.38 6.01e-13 Calcium levels; CRC cis rs728616 0.681 rs34816332 chr10:81907967 G/A cg05935833 chr10:81318306 SFTPA2 -0.54 -6.26 -0.33 1.22e-9 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs4927850 0.501 rs9881504 chr3:195656614 A/G cg12923728 chr3:195709715 SDHAP1 -0.48 -6.45 -0.34 4.02e-10 Pancreatic cancer; CRC cis rs2243480 0.666 rs1880311 chr7:65276752 G/C cg12463550 chr7:65579703 CRCP -0.73 -6.53 -0.34 2.56e-10 Diabetic kidney disease; CRC cis rs1552244 1.000 rs6772315 chr3:10113644 G/A cg13047869 chr3:10149882 C3orf24 0.56 7.7 0.39 1.63e-13 Alzheimer's disease; CRC cis rs9911578 1.000 rs1057068 chr17:56598439 T/C cg05425664 chr17:57184151 TRIM37 0.52 8.24 0.41 4.03e-15 Intelligence (multi-trait analysis); CRC cis rs7618915 0.501 rs11130308 chr3:52639257 G/C cg10802521 chr3:52805072 NEK4 -0.58 -9.08 -0.45 1e-17 Bipolar disorder; CRC trans rs2727020 0.538 rs11040373 chr11:49461791 T/C cg15704280 chr7:45808275 SEPT13 -0.69 -10.94 -0.52 5.68e-24 Coronary artery disease; CRC cis rs7726839 0.540 rs72705097 chr5:655067 G/A cg09021430 chr5:549028 NA -0.72 -8.15 -0.41 7.69e-15 Obesity-related traits; CRC cis rs6546550 0.901 rs11893500 chr2:70154187 T/C cg02498382 chr2:70120550 SNRNP27 -0.55 -9.39 -0.46 1.02e-18 Prevalent atrial fibrillation; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg18276145 chr4:72052432 SLC4A4 0.39 6.45 0.34 3.9e-10 Liver disease severity in Alagille syndrome; CRC trans rs11039798 0.764 rs11039929 chr11:48703289 A/G cg03929089 chr4:120376271 NA 0.63 6.06 0.32 3.73e-9 Axial length; CRC cis rs10751667 0.666 rs10902243 chr11:949900 T/C cg06064525 chr11:970664 AP2A2 -0.31 -6.2 -0.32 1.68e-9 Alzheimer's disease (late onset); CRC cis rs11971779 0.680 rs10261557 chr7:139099037 G/C cg07862535 chr7:139043722 LUC7L2 0.57 7.32 0.37 1.92e-12 Diisocyanate-induced asthma; CRC cis rs561341 0.941 rs17780080 chr17:30343146 G/A cg00745463 chr17:30367425 LRRC37B -0.88 -9.64 -0.47 1.51e-19 Hip circumference adjusted for BMI; CRC trans rs7011507 1.000 rs76948763 chr8:49192004 A/G cg04544946 chr8:978226 NA 0.44 6.19 0.32 1.82e-9 Inflammatory bowel disease;Ulcerative colitis; CRC cis rs317865 0.748 rs73234656 chr4:16212702 G/A cg04764131 chr4:16228633 TAPT1;FLJ39653 0.64 5.77 0.3 1.87e-8 Kidney disease (early stage) in type 1 diabetes; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg01711073 chr1:37980396 MEAF6 0.46 6.35 0.33 7.03e-10 Anxiety disorder; CRC cis rs72772090 0.634 rs10515246 chr5:96099265 A/G cg17330273 chr5:96107758 CAST;ERAP1 -0.68 -6.43 -0.33 4.51e-10 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs9322193 0.886 rs12525871 chr6:150097018 A/G cg07701084 chr6:150067640 NUP43 0.48 6.71 0.35 8.7e-11 Lung cancer; CRC cis rs2439831 0.850 rs28578398 chr15:44075046 T/C cg02155558 chr15:43621948 ADAL;LCMT2 0.69 7.61 0.39 2.95e-13 Lung cancer in ever smokers; CRC cis rs6502050 0.871 rs6502055 chr17:80070868 G/T cg19223190 chr17:80058835 NA -0.41 -6.39 -0.33 5.53e-10 Life satisfaction; CRC cis rs4332037 0.522 rs4721098 chr7:1881527 G/C cg23378565 chr7:2036160 MAD1L1 0.42 6.39 0.33 5.82e-10 Bipolar disorder; CRC cis rs1799949 1.000 rs4793215 chr17:41318932 G/A cg25072359 chr17:41440525 NA 0.43 6.36 0.33 6.83e-10 Menopause (age at onset); CRC cis rs10832963 0.924 rs10500834 chr11:18638712 A/T cg09201001 chr11:18656081 SPTY2D1 0.8 12.52 0.57 1.1e-29 Breast cancer; CRC cis rs7493 0.755 rs13228784 chr7:94960825 A/G cg19678392 chr7:94953810 PON1 -0.52 -6.52 -0.34 2.58e-10 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs10504229 0.728 rs17804750 chr8:58155751 T/C cg02290350 chr8:58132656 NA -0.51 -6.57 -0.34 1.98e-10 Developmental language disorder (linguistic errors); CRC cis rs1950626 0.623 rs3742401 chr14:101453344 G/A cg02351406 chr14:101447389 SNORD114-20;SNORD114-21 0.76 12.3 0.56 7.39e-29 Pelvic organ prolapse (moderate/severe); CRC cis rs35306767 0.855 rs35666723 chr10:867346 A/G cg20503657 chr10:835505 NA 1.23 15.05 0.64 2.68e-39 Eosinophil percentage of granulocytes; CRC cis rs10504229 0.728 rs72650852 chr8:58150463 G/A cg24829409 chr8:58192753 C8orf71 -0.65 -8.59 -0.43 3.52e-16 Developmental language disorder (linguistic errors); CRC cis rs9611565 0.559 rs5751160 chr22:42175695 A/G cg06634786 chr22:41940651 POLR3H 0.67 7.46 0.38 7.85e-13 Vitiligo; CRC cis rs6724607 1.000 rs6434402 chr2:191469322 C/T cg27211696 chr2:191398769 TMEM194B -0.4 -5.94 -0.31 7.37e-9 Pulse pressure; CRC cis rs6011002 0.745 rs1151625 chr20:62369997 C/T cg01176363 chr20:62369445 LIME1 0.73 5.68 0.3 3.02e-8 Dental caries; CRC cis rs8067354 0.645 rs2102507 chr17:57875907 A/G cg13753209 chr17:57696993 CLTC 0.44 5.81 0.3 1.49e-8 Hemoglobin concentration; CRC trans rs66573146 1.000 rs67405518 chr4:6965930 C/T cg07817883 chr1:32538562 TMEM39B 1.51 13.3 0.59 1.33e-32 Granulocyte percentage of myeloid white cells; CRC cis rs9527 0.615 rs11191401 chr10:104573403 A/G cg23093090 chr10:104574429 C10orf26 -0.43 -5.92 -0.31 8.19e-9 Arsenic metabolism; CRC cis rs11997175 0.646 rs4609158 chr8:33693420 A/G ch.8.33884649F chr8:33765107 NA 0.45 6.55 0.34 2.26e-10 Body mass index; CRC cis rs3771570 1.000 rs62190367 chr2:242376276 G/A cg21155796 chr2:242212141 HDLBP 0.63 6.85 0.35 3.64e-11 Prostate cancer; CRC trans rs2243480 0.901 rs57126451 chr7:65416306 T/C cg10756647 chr7:56101905 PSPH 0.73 8.05 0.41 1.58e-14 Diabetic kidney disease; CRC cis rs9303280 0.901 rs7216558 chr17:38070071 C/T cg11212589 chr17:38028394 ZPBP2 -0.42 -7.67 -0.39 1.92e-13 Self-reported allergy; CRC cis rs4478858 0.684 rs2062951 chr1:31762981 T/C cg00250761 chr1:31883323 NA -0.44 -8.59 -0.43 3.52e-16 Alcohol dependence; CRC cis rs9488822 0.676 rs1556857 chr6:116325559 T/C cg18764771 chr6:116381957 FRK 0.25 7.0 0.36 1.42e-11 Cholesterol, total;LDL cholesterol; CRC cis rs2841277 0.708 rs11623422 chr14:105407031 A/G cg15352829 chr14:105391018 PLD4 -0.5 -10.94 -0.52 5.95e-24 Rheumatoid arthritis; CRC cis rs1882538 0.538 rs7783217 chr7:133104117 C/G cg10665199 chr7:133106180 EXOC4 -0.65 -10.13 -0.49 3.68e-21 Intelligence (multi-trait analysis); CRC cis rs9868809 0.505 rs28567949 chr3:48744560 G/A cg00383909 chr3:49044727 WDR6 0.75 7.59 0.39 3.24e-13 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; CRC cis rs7904368 0.806 rs7087360 chr10:16872337 C/A cg14835575 chr10:16859367 RSU1 0.44 6.05 0.32 3.99e-9 Ratio of the peak velocity of the mitral E-Wave divided by the peak velocity of the mitral A-wave.; CRC cis rs2976388 1.000 rs2920296 chr8:143763109 A/G cg20041105 chr8:143859282 LYNX1 -0.32 -5.65 -0.3 3.45e-8 Urinary tract infection frequency; CRC cis rs2229774 1.000 rs11170481 chr12:53611791 C/T cg21746001 chr12:53610772 RARG -0.57 -5.98 -0.31 5.67e-9 Anthracycline-induced cardiotoxicity in childhood cancer; CRC cis rs17384381 0.859 rs12130591 chr1:85904985 C/T cg16011679 chr1:85725395 C1orf52 0.57 6.33 0.33 8.02e-10 Lobe attachment (rater-scored or self-reported); CRC cis rs7618915 0.547 rs2268027 chr3:52766606 G/A cg10802521 chr3:52805072 NEK4 -0.57 -8.77 -0.44 1.01e-16 Bipolar disorder; CRC cis rs490234 0.932 rs474489 chr9:128317881 C/G cg14078157 chr9:128172775 NA 0.35 5.81 0.31 1.45e-8 Mean arterial pressure; CRC cis rs6121246 0.909 rs6119725 chr20:30385557 G/T cg13852791 chr20:30311386 BCL2L1 0.72 11.47 0.53 7.68e-26 Mean corpuscular hemoglobin; CRC cis rs4555082 0.834 rs2735826 chr14:105710866 G/A cg18132624 chr14:105716052 BTBD6;BRF1 -0.52 -8.67 -0.43 2.04e-16 Mean platelet volume;Platelet distribution width; CRC cis rs1059312 0.808 rs4760537 chr12:129301299 C/A cg21616243 chr12:129299702 MGC16384;SLC15A4 -0.73 -12.89 -0.58 4.55e-31 Systemic lupus erythematosus; CRC cis rs1552244 1.000 rs113153120 chr3:10156398 G/A cg00166722 chr3:10149974 C3orf24 0.7 9.17 0.45 5.21e-18 Alzheimer's disease; CRC cis rs9486715 0.867 rs2475025 chr6:96988696 A/T cg06623918 chr6:96969491 KIAA0776 -1.04 -21.24 -0.76 1.22e-63 Headache; CRC cis rs7044106 0.762 rs10760115 chr9:123476952 G/A cg09419670 chr9:123605666 PSMD5;LOC253039 0.73 11.78 0.54 5.75e-27 Hip circumference adjusted for BMI; CRC cis rs1552244 1.000 rs9811771 chr3:10133949 A/G cg13047869 chr3:10149882 C3orf24 0.51 7.18 0.37 4.76e-12 Alzheimer's disease; CRC cis rs1552244 0.810 rs6809572 chr3:10100145 G/A cg00166722 chr3:10149974 C3orf24 0.7 9.53 0.46 3.69e-19 Alzheimer's disease; CRC cis rs3096299 0.719 rs2965945 chr16:89514017 T/C cg01788221 chr16:89496183 ANKRD11 -0.43 -6.56 -0.34 2.14e-10 Multiple myeloma (IgH translocation); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg25304775 chr11:64885222 ZNHIT2 0.36 5.98 0.31 5.85e-9 Liver disease severity in Alagille syndrome; CRC cis rs12681288 0.823 rs2701909 chr8:1003057 A/G cg04851639 chr8:1020857 NA -0.35 -7.5 -0.38 6.1e-13 Schizophrenia; CRC cis rs11711311 1.000 rs13073843 chr3:113449150 A/G cg15478005 chr3:113465772 ATP6V1A;NAA50 0.45 6.15 0.32 2.19e-9 IgG glycosylation; CRC cis rs10782582 0.593 rs17585530 chr1:76134990 G/A cg10523679 chr1:76189770 ACADM -0.42 -5.8 -0.3 1.57e-8 Daytime sleep phenotypes; CRC cis rs6988985 0.560 rs4418320 chr8:143944138 G/A cg10324643 chr8:143916377 GML 0.36 6.04 0.32 4.21e-9 Plasma androstenedione levels in resected early stage-receptor positive breast cancer; CRC cis rs17767392 0.846 rs12127 chr14:71956270 T/C cg13720639 chr14:72061746 SIPA1L1 -0.46 -6.08 -0.32 3.38e-9 Mitral valve prolapse; CRC cis rs7917772 0.502 rs4919670 chr10:104515799 C/A cg04362960 chr10:104952993 NT5C2 0.44 5.99 0.31 5.58e-9 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC cis rs3764400 0.567 rs67345313 chr17:46302201 T/C cg10706073 chr17:46328419 SKAP1 -0.61 -6.65 -0.34 1.22e-10 Body mass index; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg02530464 chr5:176449541 ZNF346 0.48 6.13 0.32 2.56e-9 Thyroid stimulating hormone; CRC trans rs11654801 0.812 rs11656525 chr17:20881745 T/C cg23759823 chr7:139672531 TBXAS1 -0.41 -6.12 -0.32 2.64e-9 Mosquito bite size; CRC cis rs9322193 0.923 rs57938011 chr6:149964105 T/A cg07701084 chr6:150067640 NUP43 0.57 8.0 0.4 2.2e-14 Lung cancer; CRC cis rs2180341 0.814 rs6940933 chr6:127732740 C/G cg27446573 chr6:127587934 RNF146 0.68 9.23 0.45 3.48e-18 Breast cancer; CRC cis rs68170813 0.559 rs1002935 chr7:106832361 G/A cg23293999 chr7:106826042 HBP1 -0.49 -5.61 -0.3 4.26e-8 Coronary artery disease; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg17573594 chr12:110338513 TCHP 0.45 6.09 0.32 3.09e-9 Thyroid stimulating hormone; CRC cis rs10752881 0.935 rs12082051 chr1:183051614 C/T ch.1.3577855R chr1:183094577 LAMC1 0.82 14.22 0.62 4.28e-36 Colorectal cancer; CRC cis rs3741404 0.537 rs1123251 chr11:63917601 G/T cg05555928 chr11:63887634 MACROD1 0.47 7.85 0.4 5.98e-14 Platelet count; CRC cis rs75920871 0.588 rs7119185 chr11:116886096 C/T cg01368799 chr11:117014884 PAFAH1B2 -0.43 -6.06 -0.32 3.68e-9 Subjective well-being; CRC cis rs873946 0.586 rs12259688 chr10:134549628 A/G cg27286337 chr10:134555280 INPP5A 0.72 8.9 0.44 3.71e-17 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CRC cis rs6938 0.596 rs11630918 chr15:75155896 C/T cg09165964 chr15:75287851 SCAMP5 0.55 8.69 0.43 1.72e-16 Breast cancer; CRC cis rs2976388 1.000 rs2572910 chr8:143770135 C/G cg22687807 chr8:143858763 LYNX1 -0.4 -7.01 -0.36 1.35e-11 Urinary tract infection frequency; CRC trans rs3780486 0.846 rs10971419 chr9:33124161 T/C cg04842962 chr6:43655489 MRPS18A 1.16 26.05 0.82 5.8e-82 IgG glycosylation; CRC cis rs7246657 1.000 rs8110011 chr19:37745813 G/T cg23950597 chr19:37808831 NA -0.54 -6.25 -0.33 1.3e-9 Coronary artery calcification; CRC cis rs6088580 0.634 rs6088478 chr20:32971719 T/C cg08999081 chr20:33150536 PIGU -0.6 -11.21 -0.53 6.38e-25 Glomerular filtration rate (creatinine); CRC cis rs11764590 0.813 rs11768212 chr7:1992582 A/C cg25834613 chr7:1915315 MAD1L1 -0.43 -6.31 -0.33 9.27e-10 Neuroticism; CRC cis rs1552244 0.810 rs4019706 chr3:10112862 G/A cg02579736 chr3:10068473 FANCD2;CIDECP 0.96 12.92 0.58 3.51e-31 Alzheimer's disease; CRC cis rs514406 0.679 rs11206006 chr1:53218380 A/G cg08859206 chr1:53392774 SCP2 0.63 9.81 0.48 4.26e-20 Monocyte count; CRC cis rs11971779 0.616 rs7779314 chr7:139112696 G/C cg23387468 chr7:139079360 LUC7L2 0.41 7.04 0.36 1.14e-11 Diisocyanate-induced asthma; CRC cis rs11212617 0.967 rs227067 chr11:108209360 A/G cg12106634 chr11:108092400 ATM;NPAT 0.39 5.6 0.3 4.44e-8 Response to metformin in type 2 diabetes (glycemic); CRC cis rs13108904 0.535 rs1250101 chr4:1236111 G/A cg05025164 chr4:1340916 KIAA1530 -0.55 -7.46 -0.38 7.7e-13 Obesity-related traits; CRC cis rs4819052 0.851 rs2838850 chr21:46671445 G/C cg11663144 chr21:46675770 NA -0.83 -14.35 -0.62 1.38e-36 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs873946 0.590 rs12259699 chr10:134549692 A/G cg26818010 chr10:134567672 INPP5A -0.55 -7.72 -0.39 1.36e-13 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CRC cis rs9926296 0.548 rs6500439 chr16:89808275 A/C cg03388025 chr16:89894329 SPIRE2 0.44 8.74 0.43 1.26e-16 Vitiligo; CRC cis rs6988636 0.710 rs17316158 chr8:124157607 A/C cg27053337 chr8:124217698 FAM83A 0.41 5.69 0.3 2.77e-8 Urinary uromodulin levels; CRC cis rs4713118 0.955 rs9468204 chr6:27688809 C/T cg12172441 chr6:28176163 NA 0.47 6.16 0.32 2.09e-9 Parkinson's disease; CRC cis rs2282802 0.685 rs11745502 chr5:139558808 G/A cg26211634 chr5:139558579 C5orf32 -0.44 -7.73 -0.39 1.32e-13 Intelligence (multi-trait analysis); CRC cis rs875971 0.522 rs56028712 chr7:65466565 C/T cg05627663 chr7:65219948 SNORA22;CCT6P1 0.5 7.29 0.37 2.28e-12 Aortic root size; CRC cis rs3749237 0.595 rs12489092 chr3:49550914 G/C cg02487422 chr3:49467188 NICN1 0.42 6.79 0.35 5.35e-11 Resting heart rate; CRC cis rs7312933 0.966 rs6582375 chr12:42423185 A/T cg17420585 chr12:42539391 GXYLT1 -0.43 -6.19 -0.32 1.77e-9 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CRC cis rs7618915 0.524 rs10433615 chr3:52638482 C/T cg05573699 chr3:52720067 GNL3;PBRM1 -0.46 -6.62 -0.34 1.44e-10 Bipolar disorder; CRC cis rs17401966 0.931 rs2236678 chr1:10471789 A/T cg19773385 chr1:10388646 KIF1B -0.67 -10.51 -0.5 1.84e-22 Hepatocellular carcinoma; CRC cis rs9814567 1.000 rs9829092 chr3:134229866 C/G cg06541857 chr3:134203789 ANAPC13;CEP63 -0.4 -5.95 -0.31 6.77e-9 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs9322193 0.962 rs4816 chr6:150114745 G/A cg07701084 chr6:150067640 NUP43 0.47 6.61 0.34 1.51e-10 Lung cancer; CRC cis rs10504229 0.683 rs79262965 chr8:58129826 G/T cg02290350 chr8:58132656 NA -0.59 -7.14 -0.37 6.05e-12 Developmental language disorder (linguistic errors); CRC cis rs561341 0.769 rs7217004 chr17:30178092 A/G cg00745463 chr17:30367425 LRRC37B 0.72 7.51 0.38 5.5e-13 Hip circumference adjusted for BMI; CRC cis rs4819052 0.851 rs13049337 chr21:46663460 T/G cg19498844 chr21:46707878 POFUT2;LOC642852 0.77 11.18 0.52 8.01e-25 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs933688 1.000 rs10474353 chr5:90732285 A/C cg02339078 chr5:90679543 LOC100129716;ARRDC3 0.94 14.67 0.63 7.72e-38 Smoking behavior; CRC cis rs501916 0.634 rs1561483 chr15:48069488 A/C cg16110827 chr15:48056943 SEMA6D -0.42 -6.14 -0.32 2.35e-9 Inflammatory bowel disease;Ulcerative colitis; CRC cis rs8177179 0.505 rs1405023 chr3:133481128 T/C cg01448562 chr3:133502909 NA 0.37 5.84 0.31 1.23e-8 Iron status biomarkers (transferrin levels); CRC cis rs921968 0.541 rs1863704 chr2:219562675 C/T cg02176678 chr2:219576539 TTLL4 -0.6 -9.57 -0.47 2.65e-19 Mean corpuscular hemoglobin concentration; CRC cis rs4141404 0.923 rs2413046 chr22:31665909 C/A cg22777020 chr22:31556080 RNF185 -0.51 -5.86 -0.31 1.15e-8 Paclitaxel-induced neuropathy; CRC cis rs2404602 0.583 rs11072580 chr15:76540231 G/A cg03037974 chr15:76606532 NA 0.77 14.52 0.63 2.86e-37 Blood metabolite levels; CRC cis rs2032447 0.765 rs1935235 chr6:26067782 C/G cg18357526 chr6:26021779 HIST1H4A 0.75 11.29 0.53 3.33e-25 Intelligence (multi-trait analysis); CRC cis rs9522267 0.535 rs6492373 chr13:112238627 T/C cg14352298 chr13:112236639 NA -0.27 -6.11 -0.32 2.87e-9 Hepatitis; CRC cis rs59104589 0.617 rs60178325 chr2:242300651 A/T cg19488206 chr2:242435732 STK25 0.47 6.68 0.35 1.02e-10 Fibrinogen levels; CRC cis rs4713118 0.513 rs149989 chr6:27998184 T/A cg12172441 chr6:28176163 NA 0.52 7.29 0.37 2.4e-12 Parkinson's disease; CRC cis rs2019137 0.836 rs4848318 chr2:113953952 T/C cg12889195 chr2:113992843 PAX8;LOC440839;LOC654433 -0.51 -7.36 -0.38 1.5e-12 Lymphocyte counts; CRC cis rs7113874 0.589 rs10840060 chr11:8500045 A/C cg17679104 chr11:8615758 STK33 0.36 5.89 0.31 9.64e-9 Body mass index in physically active individuals;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs4927850 1.000 rs7627706 chr3:195753353 A/C cg12923728 chr3:195709715 SDHAP1 -0.7 -10.9 -0.52 7.9e-24 Pancreatic cancer; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg16221841 chr14:77279127 ANGEL1 0.44 6.29 0.33 9.93e-10 Anxiety disorder; CRC cis rs6764363 0.565 rs625589 chr3:288775 A/T cg02057681 chr3:285234 CHL1 -0.41 -6.71 -0.35 8.73e-11 Sudden cardiac arrest; CRC trans rs4263408 0.934 rs9683743 chr4:39703194 A/C cg12585429 chr16:49889252 NA -0.41 -6.04 -0.32 4.12e-9 Plasma amyloid beta peptide concentrations (ABx-40); CRC cis rs4481887 0.927 rs4244184 chr1:248486895 G/T cg13385794 chr1:248469461 NA 0.38 6.66 0.34 1.14e-10 Common traits (Other); CRC cis rs240110 0.539 rs6934256 chr6:101338728 G/A cg09795085 chr6:101329169 ASCC3 0.49 6.83 0.35 4.09e-11 Neuroticism; CRC trans rs1814175 0.817 rs4405313 chr11:50013636 G/A cg03929089 chr4:120376271 NA -0.95 -19.14 -0.73 2.04e-55 Height; CRC cis rs13256369 0.950 rs13248096 chr8:8577476 C/T cg18904891 chr8:8559673 CLDN23 0.5 6.84 0.35 3.83e-11 Obesity-related traits; CRC cis rs9368481 0.729 rs9379950 chr6:26961548 T/C cg07220782 chr6:26987966 LOC100270746;C6orf41 -0.41 -5.72 -0.3 2.44e-8 Autism spectrum disorder or schizophrenia; CRC trans rs1005277 0.540 rs116205409 chr10:38478970 G/A cg17830980 chr10:43048298 ZNF37B -0.6 -9.93 -0.48 1.76e-20 Extrinsic epigenetic age acceleration; CRC cis rs854765 0.929 rs854766 chr17:18012775 A/G cg04398451 chr17:18023971 MYO15A -0.59 -10.43 -0.5 3.35e-22 Total body bone mineral density; CRC cis rs6541297 1.000 rs4846838 chr1:230281618 G/A cg05784532 chr1:230284198 GALNT2 0.55 6.96 0.36 1.88e-11 Coronary artery disease; CRC cis rs7586879 0.828 rs11675013 chr2:25107208 G/A cg22495460 chr2:25135724 ADCY3 -0.87 -14.99 -0.64 4.51e-39 Body mass index; CRC trans rs6703335 0.870 rs10803142 chr1:243598234 A/G cg00887444 chr13:31248228 NA 0.44 6.04 0.32 4.12e-9 Schizophrenia;Schizophrenia, schizoaffective disorder or bipolar disorder; CRC cis rs804280 0.662 rs7826055 chr8:11611723 G/C cg23972785 chr8:11611189 GATA4 -0.4 -5.68 -0.3 2.89e-8 Myopia (pathological); CRC cis rs916888 0.821 rs199525 chr17:44847834 T/G cg17911788 chr17:44343683 NA -0.66 -7.27 -0.37 2.69e-12 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs4713118 0.513 rs149962 chr6:28015918 G/A cg23161317 chr6:28129485 ZNF389 0.44 6.27 0.33 1.16e-9 Parkinson's disease; CRC cis rs7020830 0.898 rs308492 chr9:37298020 C/T cg14294708 chr9:37120828 ZCCHC7 1.07 21.65 0.77 3.11e-65 Schizophrenia; CRC cis rs8180040 0.620 rs11709660 chr3:47074927 G/A cg10298567 chr3:47292165 KIF9 0.38 5.96 0.31 6.55e-9 Colorectal cancer; CRC cis rs28386778 0.897 rs2665795 chr17:61925272 A/G cg06601766 chr17:61851465 DDX42;CCDC47 -0.43 -5.94 -0.31 7.26e-9 Prudent dietary pattern; CRC cis rs7613875 0.620 rs11721204 chr3:49982765 C/T cg24110177 chr3:50126178 RBM5 -0.55 -8.12 -0.41 9.35e-15 Body mass index; CRC cis rs7811142 1.000 rs7787620 chr7:100089234 A/G cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.6 7.74 0.39 1.27e-13 Platelet count; CRC cis rs11785400 0.793 rs4567014 chr8:143737690 G/C cg10596483 chr8:143751796 JRK 0.44 5.89 0.31 9.35e-9 Schizophrenia; CRC cis rs7552404 1.000 rs211723 chr1:76103030 C/T cg10523679 chr1:76189770 ACADM -0.77 -10.63 -0.51 6.97e-23 Blood metabolite levels;Acylcarnitine levels; CRC cis rs1799949 1.000 rs8176220 chr17:41222462 A/G cg25072359 chr17:41440525 NA 0.47 7.04 0.36 1.11e-11 Menopause (age at onset); CRC cis rs9322193 0.923 rs1112729 chr6:150087627 C/A cg00933542 chr6:150070202 PCMT1 0.28 5.69 0.3 2.75e-8 Lung cancer; CRC cis rs2730260 0.537 rs55864635 chr7:158859744 C/T cg02254261 chr7:158964346 NA -0.51 -5.86 -0.31 1.15e-8 Myopia (pathological); CRC cis rs7923609 0.967 rs7095571 chr10:65150959 T/G cg08743896 chr10:65200160 JMJD1C -0.42 -5.95 -0.31 6.74e-9 Educational attainment;Liver enzyme levels (alkaline phosphatase); CRC cis rs9322193 0.923 rs2342765 chr6:150180009 C/G cg07701084 chr6:150067640 NUP43 0.42 5.95 0.31 6.87e-9 Lung cancer; CRC cis rs727563 0.593 rs5758461 chr22:42162189 G/C cg03806693 chr22:41940476 POLR3H 1.1 13.52 0.6 2e-33 Crohn's disease;Inflammatory bowel disease; CRC trans rs1814175 0.645 rs11040671 chr11:49958776 G/A cg15704280 chr7:45808275 SEPT13 -0.94 -16.88 -0.68 1.75e-46 Height; CRC cis rs6502050 0.835 rs6502077 chr17:80122966 G/C cg22110888 chr17:80059540 CCDC57 0.4 6.38 0.33 5.96e-10 Life satisfaction; CRC cis rs17376456 0.825 rs13171131 chr5:93223028 C/T cg25358565 chr5:93447407 FAM172A 1.05 10.23 0.49 1.68e-21 Diabetic retinopathy; CRC cis rs883565 0.528 rs9818979 chr3:38963835 C/G cg01426195 chr3:39028469 NA 0.38 6.38 0.33 5.95e-10 Handedness; CRC cis rs28386778 0.769 rs6504179 chr17:61812995 T/G cg23090583 chr17:61904693 PSMC5;FTSJ3 0.97 16.88 0.68 1.68e-46 Prudent dietary pattern; CRC cis rs8044995 0.563 rs3743743 chr16:68397775 C/T cg05110241 chr16:68378359 PRMT7 -0.76 -7.61 -0.39 2.95e-13 Schizophrenia; CRC trans rs2727020 0.521 rs10839296 chr11:49537617 T/C cg11707556 chr5:10655725 ANKRD33B 0.47 7.66 0.39 2.06e-13 Coronary artery disease; CRC cis rs35740288 0.571 rs11633790 chr15:86326370 G/A cg20737812 chr15:86336631 KLHL25 -0.43 -6.62 -0.34 1.44e-10 Eosinophil percentage of white cells;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes; CRC cis rs853679 0.517 rs9380062 chr6:28137569 G/A cg12172441 chr6:28176163 NA 0.64 7.53 0.38 5.03e-13 Depression; CRC cis rs7772486 0.790 rs2265472 chr6:146220758 G/C cg13319975 chr6:146136371 FBXO30 -0.41 -6.16 -0.32 2.18e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs1552244 0.938 rs34750074 chr3:10091740 G/A cg16606324 chr3:10149918 C3orf24 0.72 9.72 0.47 8.68e-20 Alzheimer's disease; CRC trans rs1814175 0.817 rs10769648 chr11:50013992 T/C cg03929089 chr4:120376271 NA -0.95 -19.14 -0.73 2.04e-55 Height; CRC cis rs67311347 0.911 rs58282210 chr3:40417943 C/T cg09455208 chr3:40491958 NA 0.43 8.58 0.43 3.84e-16 Renal cell carcinoma; CRC cis rs9649213 0.593 rs35983874 chr7:97916461 C/T cg00277769 chr7:97922759 BAIAP2L1 -0.61 -10.73 -0.51 3.23e-23 Prostate cancer (SNP x SNP interaction); CRC cis rs344364 0.511 rs1742469 chr16:1950244 C/T cg03013636 chr16:1946785 NA 0.58 7.08 0.36 8.69e-12 Glomerular filtration rate in chronic kidney disease; CRC cis rs10504229 0.683 rs17194529 chr8:58105647 A/G cg22535103 chr8:58192502 C8orf71 -0.72 -7.98 -0.4 2.44e-14 Developmental language disorder (linguistic errors); CRC cis rs10450586 0.932 rs10742172 chr11:27314297 C/T cg10370305 chr11:27303972 NA 0.35 5.69 0.3 2.76e-8 Total body bone mineral density; CRC cis rs8180040 0.739 rs66539935 chr3:47025327 C/T cg02527881 chr3:46936655 PTH1R 0.39 7.16 0.37 5.33e-12 Colorectal cancer; CRC cis rs9747201 1.000 rs36048409 chr17:80096961 T/A cg09264619 chr17:80180166 NA 0.51 7.32 0.37 1.9e-12 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs7727544 0.901 rs55633655 chr5:131598756 T/G cg09877947 chr5:131593287 PDLIM4 0.36 6.73 0.35 7.53e-11 Blood metabolite levels; CRC cis rs798554 0.959 rs798556 chr7:2759002 C/A cg13628971 chr7:2884303 GNA12 0.47 6.47 0.34 3.58e-10 Height; CRC cis rs59918340 0.764 rs753779 chr8:142228809 T/C cg23750338 chr8:142222470 SLC45A4 0.61 11.25 0.53 4.79e-25 Immature fraction of reticulocytes; CRC cis rs1506636 0.539 rs17701547 chr7:123383461 A/G cg03229431 chr7:123269106 ASB15 -0.71 -8.63 -0.43 2.66e-16 Plateletcrit;Platelet count; CRC cis rs10089 1.000 rs72794392 chr5:127490061 A/T cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.71 9.22 0.45 3.71e-18 Ileal carcinoids; CRC cis rs7772486 0.875 rs2492855 chr6:146296926 A/G cg23711669 chr6:146136114 FBXO30 0.6 10.1 0.49 4.48e-21 Lobe attachment (rater-scored or self-reported); CRC cis rs875971 0.502 rs11769702 chr7:65720516 A/C cg11764359 chr7:65958608 NA 0.46 5.69 0.3 2.85e-8 Aortic root size; CRC cis rs3617 0.539 rs4687689 chr3:52948674 A/C cg18099408 chr3:52552593 STAB1 0.34 5.95 0.31 6.78e-9 Red blood cell count;Autism spectrum disorder or schizophrenia; CRC cis rs2153535 0.580 rs7743995 chr6:8496212 A/G cg21535247 chr6:8435926 SLC35B3 0.47 7.03 0.36 1.2e-11 Motion sickness; CRC trans rs4308415 0.781 rs12498631 chr4:67811543 T/C cg19648955 chr2:177134095 MTX2 -0.43 -6.34 -0.33 7.43e-10 Educational attainment (years of education); CRC cis rs113835537 0.935 rs15969 chr11:66394387 C/T cg22134325 chr11:66188745 NPAS4 0.37 6.11 0.32 2.86e-9 Airway imaging phenotypes; CRC cis rs881375 0.967 rs7034653 chr9:123687372 G/A cg09419670 chr9:123605666 PSMD5;LOC253039 0.57 8.48 0.42 7.92e-16 Rheumatoid arthritis; CRC cis rs9467711 0.516 rs1324087 chr6:25841408 A/G cg08501292 chr6:25962987 TRIM38 -0.64 -6.94 -0.36 2.09e-11 Autism spectrum disorder or schizophrenia; CRC cis rs7208859 0.623 rs35916850 chr17:29011173 G/A cg19761014 chr17:28927070 LRRC37B2 0.6 5.89 0.31 9.61e-9 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs708547 0.836 rs1315005 chr4:57858237 C/G cg25525207 chr4:57843836 C4orf14;POLR2B -0.57 -8.01 -0.4 1.95e-14 Response to bleomycin (chromatid breaks); CRC cis rs3771570 1.000 rs57196672 chr2:242235193 G/A cg21155796 chr2:242212141 HDLBP 0.65 6.98 0.36 1.68e-11 Prostate cancer; CRC cis rs2565722 0.825 rs1247540 chr6:161253016 G/A cg03159191 chr6:161285451 NA -0.48 -5.81 -0.31 1.46e-8 Blood protein levels; CRC cis rs9486719 1.000 rs4078038 chr6:96904366 A/G cg18709589 chr6:96969512 KIAA0776 -0.5 -5.61 -0.3 4.32e-8 Migraine;Coronary artery disease; CRC cis rs7615952 0.799 rs13315434 chr3:125641394 T/G cg05084668 chr3:125655381 ALG1L -0.6 -8.82 -0.44 6.96e-17 Blood pressure (smoking interaction); CRC cis rs11212617 0.905 rs172927 chr11:108124299 G/A cg01991180 chr11:108092276 ATM;NPAT 0.41 5.82 0.31 1.43e-8 Response to metformin in type 2 diabetes (glycemic); CRC cis rs972578 0.936 rs2267486 chr22:43384017 C/A cg01576275 chr22:43409880 NA -0.48 -7.71 -0.39 1.47e-13 Mean platelet volume; CRC trans rs7395662 0.517 rs2021248 chr11:49013054 C/T cg15704280 chr7:45808275 SEPT13 -0.52 -7.37 -0.38 1.36e-12 HDL cholesterol; CRC cis rs780096 0.546 rs6547626 chr2:27646770 C/T cg24768116 chr2:27665128 KRTCAP3 -0.35 -7.99 -0.4 2.25e-14 Total body bone mineral density; CRC cis rs6964587 0.773 rs12740 chr7:92029302 A/G cg17063962 chr7:91808500 NA 0.66 10.25 0.49 1.36e-21 Breast cancer; CRC cis rs2075371 1.000 rs2244694 chr7:133987093 C/T cg02659138 chr7:134003124 SLC35B4 0.4 6.96 0.36 1.84e-11 Mean platelet volume; CRC cis rs7811142 1.000 rs73405353 chr7:100091215 G/A cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.16 16.12 0.66 1.72e-43 Platelet count; CRC cis rs929354 0.772 rs1182448 chr7:157021415 G/A cg05182265 chr7:156933206 UBE3C 0.76 14.55 0.63 2.33e-37 Body mass index; CRC cis rs2652834 1.000 rs2652835 chr15:63396408 T/C cg05507819 chr15:63340323 TPM1 0.47 6.22 0.32 1.52e-9 HDL cholesterol; CRC cis rs853679 0.607 rs33932084 chr6:28268824 A/G cg15845792 chr6:28175446 NA 0.84 5.82 0.31 1.37e-8 Depression; CRC cis rs9837602 0.507 rs1718244 chr3:99512608 C/T cg07805332 chr3:99536008 MIR548G;C3orf26 0.5 7.38 0.38 1.33e-12 Breast cancer; CRC cis rs8031584 0.541 rs2955777 chr15:31219788 A/C cg08109568 chr15:31115862 NA 0.4 6.55 0.34 2.26e-10 Huntington's disease progression; CRC cis rs7932354 0.583 rs10769212 chr11:46893498 C/A cg19486271 chr11:47235900 DDB2 -0.42 -6.36 -0.33 6.58e-10 Bone mineral density (hip);Bone mineral density; CRC cis rs9916302 0.706 rs11655972 chr17:37407072 C/T cg15445000 chr17:37608096 MED1 0.35 6.2 0.32 1.69e-9 Glomerular filtration rate (creatinine); CRC cis rs853679 0.517 rs9393886 chr6:28050039 T/G cg03623178 chr6:28175578 NA 0.92 12.19 0.56 1.91e-28 Depression; CRC cis rs1552244 1.000 rs7610821 chr3:10136150 C/T cg13047869 chr3:10149882 C3orf24 0.51 7.2 0.37 4.24e-12 Alzheimer's disease; CRC cis rs6089829 1.000 rs6089828 chr20:61668998 C/T cg03213289 chr20:61660250 NA 0.35 7.11 0.36 7.27e-12 Prostate cancer (SNP x SNP interaction); CRC cis rs3733585 0.660 rs13122290 chr4:9933832 A/G cg11266682 chr4:10021025 SLC2A9 -0.52 -10.56 -0.5 1.22e-22 Cleft plate (environmental tobacco smoke interaction); CRC cis rs2976388 0.566 rs6998746 chr8:143802456 A/C cg04969067 chr8:143858791 LYNX1 0.41 6.43 0.33 4.42e-10 Urinary tract infection frequency; CRC cis rs17376456 0.825 rs6898842 chr5:93213221 T/C cg21475434 chr5:93447410 FAM172A 0.81 7.68 0.39 1.89e-13 Diabetic retinopathy; CRC trans rs4843747 0.519 rs12599755 chr16:88107006 A/G cg26811252 chr16:29126840 RRN3P2 0.72 9.61 0.47 1.95e-19 Menopause (age at onset); CRC cis rs7249142 0.562 rs10418053 chr19:19287164 A/G cg12558012 chr19:19281197 LOC729991-MEF2B;MEF2B 0.55 8.57 0.43 4.05e-16 IgG glycosylation; CRC cis rs5769765 0.908 rs9616213 chr22:50317851 T/G cg02269571 chr22:50332266 NA -0.62 -7.71 -0.39 1.5e-13 Schizophrenia; CRC cis rs847577 0.508 rs12538837 chr7:97684468 C/T cg21770322 chr7:97807741 LMTK2 0.54 7.89 0.4 4.44e-14 Breast cancer; CRC cis rs936229 0.656 rs12898397 chr15:75130093 T/C cg17294928 chr15:75287854 SCAMP5 0.45 6.82 0.35 4.48e-11 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); CRC cis rs875971 0.862 rs11760844 chr7:65739883 C/G cg12463550 chr7:65579703 CRCP -0.53 -7.42 -0.38 9.97e-13 Aortic root size; CRC cis rs887829 0.641 rs10167119 chr2:234589312 T/C cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.42 -6.32 -0.33 8.45e-10 Metabolic traits;Bilirubin levels;Cholelithiasis-related traits in sickle cell anemia;Metabolite levels;Total bilirubin levels in HIV-1 infection;Serum metabolite levels;Blood metabolite levels; CRC cis rs7044106 0.718 rs1981021 chr9:123388393 T/G cg09419670 chr9:123605666 PSMD5;LOC253039 0.73 12.03 0.55 7.15e-28 Hip circumference adjusted for BMI; CRC cis rs7552404 0.731 rs10873788 chr1:76367857 A/C cg10523679 chr1:76189770 ACADM 0.66 8.2 0.41 5.5e-15 Blood metabolite levels;Acylcarnitine levels; CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg23526204 chr20:43992176 SYS1;SYS1-DBNDD2 0.39 6.0 0.31 5.28e-9 Obesity-related traits; CRC cis rs7786877 0.723 rs10487157 chr7:100214487 C/G cg20848291 chr7:100343083 ZAN -0.55 -6.99 -0.36 1.57e-11 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC trans rs9354308 0.933 rs2814131 chr6:66562051 T/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.47 5.99 0.31 5.47e-9 Metabolite levels; CRC cis rs9427116 0.532 rs9426828 chr1:154591489 G/A cg17218026 chr1:154582156 ADAR 0.66 11.46 0.53 8.55e-26 Blood protein levels; CRC trans rs12599106 0.792 rs11648801 chr16:34360980 C/T cg18110333 chr6:292329 DUSP22 -0.59 -8.58 -0.43 3.93e-16 Menopause (age at onset); CRC cis rs2836950 0.501 rs2836984 chr21:40700949 A/C cg06238570 chr21:40685208 BRWD1 -0.56 -8.01 -0.4 2.05e-14 Menarche (age at onset); CRC cis rs2153535 0.580 rs6913100 chr6:8456855 A/G cg21535247 chr6:8435926 SLC35B3 0.51 7.91 0.4 3.89e-14 Motion sickness; CRC cis rs601339 0.877 rs2649991 chr12:123179461 A/G cg25190513 chr12:123201362 GPR109B -0.49 -6.27 -0.33 1.11e-9 Adiponectin levels; CRC cis rs7833790 0.632 rs6415653 chr8:82702536 A/G cg17211192 chr8:82754475 SNX16 -0.46 -6.16 -0.32 2.15e-9 Diastolic blood pressure; CRC cis rs4665809 0.838 rs2243834 chr2:26357748 A/C cg22920501 chr2:26401640 FAM59B 0.54 7.46 0.38 7.55e-13 Gut microbiome composition (summer); CRC cis rs4629710 0.562 rs3798252 chr6:131583758 A/T cg12606694 chr6:131520996 AKAP7 0.53 8.0 0.4 2.19e-14 Multiple myeloma (IgH translocation); CRC cis rs910316 1.000 rs910316 chr14:75626042 A/C cg08847533 chr14:75593920 NEK9 0.96 18.42 0.71 1.43e-52 Height; CRC cis rs9814567 0.752 rs13075253 chr3:134329600 G/A cg06109529 chr3:134205091 CEP63;ANAPC13 0.68 9.82 0.48 3.92e-20 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs8062405 1.000 rs2008514 chr16:28825605 A/G cg16576597 chr16:28551801 NUPR1 -0.48 -7.03 -0.36 1.19e-11 Cognitive ability (multi-trait analysis);Cognitive ability; CRC cis rs2204008 0.506 rs11495470 chr12:38026904 C/T cg26384229 chr12:38710491 ALG10B 0.67 9.3 0.46 2.04e-18 Bladder cancer; CRC trans rs12195424 0.730 rs9475698 chr6:56298924 A/G cg10659575 chr11:102188233 BIRC3 0.51 6.03 0.32 4.34e-9 Cerebrospinal fluid clusterin levels; CRC cis rs7666738 0.830 rs7682991 chr4:98982595 C/A cg17366294 chr4:99064904 C4orf37 0.43 7.33 0.37 1.76e-12 Colonoscopy-negative controls vs population controls; CRC cis rs4409675 0.576 rs11247705 chr1:28212272 G/A cg23691781 chr1:28212827 C1orf38 0.33 7.72 0.39 1.39e-13 Corneal astigmatism; CRC cis rs10504229 1.000 rs73607871 chr8:58173007 T/C cg22535103 chr8:58192502 C8orf71 -0.82 -12.27 -0.56 9.63e-29 Developmental language disorder (linguistic errors); CRC cis rs3754214 0.857 rs9126 chr1:150259400 A/C cg15654264 chr1:150340011 RPRD2 -0.39 -5.84 -0.31 1.22e-8 Cerebrospinal fluid biomarker levels; CRC trans rs9784649 0.882 rs2201296 chr5:24967119 G/A cg11038491 chr20:34638489 LOC647979 -0.59 -7.18 -0.37 4.59e-12 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs4665809 0.556 rs10221814 chr2:26442759 C/T cg27170947 chr2:26402098 FAM59B -0.63 -8.51 -0.42 6.43e-16 Gut microbiome composition (summer); CRC cis rs62064224 0.589 rs9903650 chr17:30689370 T/A cg09324608 chr17:30823087 MYO1D 0.33 5.72 0.3 2.43e-8 Schizophrenia; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg21684385 chr6:143772210 ADAT2;PEX3 0.44 6.08 0.32 3.27e-9 Response to antipsychotic treatment; CRC cis rs7615952 0.599 rs6438955 chr3:125730333 C/A cg06494592 chr3:125709126 NA -0.53 -6.73 -0.35 7.61e-11 Blood pressure (smoking interaction); CRC cis rs12325245 0.536 rs34676074 chr16:58549321 G/C cg21335942 chr16:58549945 SETD6 0.91 5.86 0.31 1.13e-8 Schizophrenia; CRC cis rs9926296 0.585 rs8058009 chr16:89856439 G/A cg03388025 chr16:89894329 SPIRE2 0.36 6.7 0.35 9.18e-11 Vitiligo; CRC cis rs728616 0.717 rs116884206 chr10:81990546 A/G cg11900509 chr10:81946545 ANXA11 -0.74 -6.9 -0.36 2.65e-11 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs9372498 0.572 rs62422230 chr6:118959436 T/C cg01339444 chr6:118972232 C6orf204 0.56 6.09 0.32 3.14e-9 Diastolic blood pressure; CRC cis rs8180040 0.966 rs11716763 chr3:47518266 C/T cg02527881 chr3:46936655 PTH1R 0.38 7.08 0.36 8.93e-12 Colorectal cancer; CRC cis rs3820068 0.581 rs72645879 chr1:15928199 A/G cg27534772 chr1:16042836 PLEKHM2 0.54 10.46 0.5 2.7e-22 Systolic blood pressure; CRC cis rs9517320 1.000 rs7996093 chr13:99133092 T/C cg07423050 chr13:99094983 FARP1 0.4 6.29 0.33 9.91e-10 Longevity; CRC cis rs11098499 0.820 rs13122709 chr4:120555356 T/A cg09307838 chr4:120376055 NA 0.71 10.48 0.5 2.36e-22 Corneal astigmatism; CRC cis rs1003719 0.751 rs7280371 chr21:38450008 T/C cg10648535 chr21:38446584 PIGP;TTC3 0.53 7.48 0.38 6.64e-13 Eye color traits; CRC cis rs60843830 0.964 rs7584915 chr2:264227 G/A cg00108164 chr2:264199 ACP1;SH3YL1 0.61 9.75 0.47 6.72e-20 Spherical equivalent (joint analysis main effects and education interaction); CRC trans rs10504229 1.000 rs73609764 chr8:58192971 G/A cg04077850 chr5:125800366 GRAMD3 0.37 6.27 0.33 1.15e-9 Developmental language disorder (linguistic errors); CRC cis rs2462686 1.000 rs809298 chr7:45998344 C/A cg15898840 chr7:45960834 IGFBP3 -0.39 -5.86 -0.31 1.11e-8 Major depressive disorder; CRC cis rs477895 0.838 rs1058735 chr11:64000410 C/G cg04317338 chr11:64019027 PLCB3 0.7 8.59 0.43 3.49e-16 Mean platelet volume; CRC cis rs13064411 0.696 rs6786974 chr3:113190149 T/A cg10517650 chr3:113235015 CCDC52 -0.38 -6.66 -0.34 1.14e-10 Response to simvastatin treatment (PCSK9 protein level change); CRC cis rs7772486 0.686 rs9497395 chr6:146013592 A/G cg23711669 chr6:146136114 FBXO30 -0.64 -10.4 -0.5 4.29e-22 Lobe attachment (rater-scored or self-reported); CRC cis rs2404602 0.647 rs4312276 chr15:77164361 T/C cg03037974 chr15:76606532 NA -0.53 -7.55 -0.38 4.22e-13 Blood metabolite levels; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg11287903 chr10:115613834 DCLRE1A;NHLRC2 0.51 7.39 0.38 1.22e-12 Response to antipsychotic treatment; CRC cis rs9487051 0.837 rs2356817 chr6:109642675 G/A cg01475377 chr6:109611718 NA -0.42 -7.49 -0.38 6.5e-13 Reticulocyte fraction of red cells; CRC cis rs733592 0.524 rs10875726 chr12:48425992 A/G cg24011408 chr12:48396354 COL2A1 -0.43 -6.34 -0.33 7.41e-10 Plateletcrit; CRC cis rs11971779 0.680 rs9683 chr7:139107739 T/A cg23387468 chr7:139079360 LUC7L2 0.41 7.05 0.36 1.04e-11 Diisocyanate-induced asthma; CRC cis rs2839186 0.647 rs9976233 chr21:47616913 G/A cg09417038 chr21:47716443 C21orf57 0.38 6.64 0.34 1.3100000000000001e-10 Testicular germ cell tumor; CRC cis rs1799949 1.000 rs35956818 chr17:41422985 T/C cg19454999 chr17:41278357 BRCA1;NBR2 0.52 8.12 0.41 9.78e-15 Menopause (age at onset); CRC cis rs7937682 0.924 rs495460 chr11:111504777 G/A cg09085632 chr11:111637200 PPP2R1B -0.99 -19.28 -0.73 5.84e-56 Primary sclerosing cholangitis; CRC cis rs10791097 0.694 rs2236717 chr11:130739887 G/T cg12179176 chr11:130786555 SNX19 0.75 12.76 0.58 1.4e-30 Autism spectrum disorder or schizophrenia;Schizophrenia; CRC cis rs35306767 0.714 rs17293608 chr10:1056252 C/T cg20503657 chr10:835505 NA 0.87 10.66 0.51 5.49e-23 Eosinophil percentage of granulocytes; CRC cis rs9326248 1.000 rs664971 chr11:117070857 A/G cg10130564 chr11:117069849 TAGLN -0.39 -7.38 -0.38 1.34e-12 Blood protein levels; CRC cis rs2404602 0.716 rs4079681 chr15:76695230 G/A cg23625390 chr15:77176239 SCAPER 0.5 7.33 0.37 1.8e-12 Blood metabolite levels; CRC cis rs2739330 0.828 rs5760107 chr22:24252597 T/C cg11905131 chr22:24372483 LOC391322 -0.71 -11.44 -0.53 9.46e-26 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs3800461 0.544 rs76990047 chr6:34504042 T/G cg17674042 chr6:34482479 PACSIN1 -0.92 -9.2 -0.45 4.09e-18 Chronic lymphocytic leukemia; CRC cis rs7666738 0.830 rs34671152 chr4:98978177 C/T cg17366294 chr4:99064904 C4orf37 0.44 7.44 0.38 8.98e-13 Colonoscopy-negative controls vs population controls; CRC cis rs854572 0.870 rs757158 chr7:94955528 C/T cg19678392 chr7:94953810 PON1 -0.8 -13.33 -0.59 1.03e-32 Paraoxonase activity; CRC cis rs7607369 0.574 rs12990478 chr2:219667463 T/A cg02176678 chr2:219576539 TTLL4 -0.37 -5.92 -0.31 7.91e-9 Red blood cell count;Amyotrophic lateral sclerosis; CRC cis rs208520 0.661 rs6937856 chr6:66867468 A/G cg07460842 chr6:66804631 NA -1.07 -14.89 -0.63 1.12e-38 Exhaled nitric oxide output; CRC cis rs6693567 0.507 rs4970964 chr1:150458029 A/G cg04165759 chr1:150448943 RPRD2 0.35 5.72 0.3 2.44e-8 Migraine; CRC cis rs6785206 0.772 rs6439134 chr3:128323504 C/T cg16766828 chr3:128327626 NA -0.5 -5.74 -0.3 2.18e-8 Lymphocyte percentage of white cells; CRC cis rs3820068 0.529 rs79570154 chr1:15990912 T/C cg13390004 chr1:15929781 NA 0.53 7.25 0.37 2.99e-12 Systolic blood pressure; CRC cis rs798554 0.796 rs2533884 chr7:2836848 T/G cg14895029 chr7:2775587 GNA12 -0.45 -6.49 -0.34 3.18e-10 Height; CRC cis rs6942756 0.531 rs9649531 chr7:128927659 T/C cg02491457 chr7:128862824 NA 0.54 7.75 0.39 1.14e-13 White matter hyperintensity burden; CRC cis rs7940866 0.678 rs61909201 chr11:130839547 C/T cg12179176 chr11:130786555 SNX19 0.57 7.59 0.39 3.33e-13 Schizophrenia; CRC cis rs12497850 0.931 rs11705888 chr3:48817289 T/C cg07636037 chr3:49044803 WDR6 1.02 18.11 0.71 2.41e-51 Parkinson's disease; CRC cis rs4713118 0.662 rs9380046 chr6:28030499 T/C cg23161317 chr6:28129485 ZNF389 0.44 5.73 0.3 2.27e-8 Parkinson's disease; CRC cis rs6546550 0.933 rs1454498 chr2:70149225 C/A cg02498382 chr2:70120550 SNRNP27 -0.56 -9.52 -0.46 3.78e-19 Prevalent atrial fibrillation; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg01015199 chr6:53409878 GCLC 0.51 7.37 0.38 1.4e-12 Anxiety disorder; CRC cis rs7727544 0.547 rs10076758 chr5:131524299 A/G cg02033258 chr5:131593261 PDLIM4 0.31 5.6 0.3 4.5e-8 Blood metabolite levels; CRC cis rs9399135 0.967 rs4896120 chr6:135293512 C/G cg24558204 chr6:135376177 HBS1L 0.48 7.36 0.38 1.49e-12 Red blood cell count; CRC cis rs17253792 0.822 rs78395034 chr14:56069783 G/A cg01858014 chr14:56050164 KTN1 -0.87 -7.23 -0.37 3.34e-12 Putamen volume; CRC cis rs9359856 0.564 rs1179902 chr6:90321545 C/T cg13799429 chr6:90582589 CASP8AP2 -0.71 -7.88 -0.4 4.72e-14 Bipolar disorder; CRC cis rs9400239 0.622 rs1268169 chr6:109007977 A/C cg11073813 chr6:109029018 NA -0.39 -6.2 -0.32 1.72e-9 Waist circumference;Body mass index;BMI (adjusted for smoking behaviour); CRC cis rs2213920 0.679 rs4979536 chr9:118213738 C/T cg13918206 chr9:118159781 DEC1 0.61 5.82 0.31 1.4e-8 Docetaxel-induced peripheral neuropathy in metastatic castrate-resistant prostate cancer; CRC trans rs6066835 0.702 rs6095228 chr20:47279876 A/G cg21109867 chr19:55897418 RPL28 0.74 5.98 0.31 5.73e-9 Multiple myeloma; CRC trans rs660498 0.785 rs2484204 chr10:27738002 G/A cg13661793 chr10:32399026 NA -0.34 -6.11 -0.32 2.76e-9 Asthma (childhood onset); CRC cis rs9811920 0.809 rs793476 chr3:99541747 G/T cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G -0.4 -5.67 -0.3 3.2e-8 Axial length; CRC cis rs7605827 0.930 rs13017972 chr2:15699739 A/G cg19274914 chr2:15703543 NA 0.37 5.65 0.3 3.57e-8 Educational attainment (years of education); CRC cis rs798554 0.591 rs1182156 chr7:2901084 G/T cg04166393 chr7:2884313 GNA12 0.38 5.7 0.3 2.64e-8 Height; CRC cis rs9467711 0.606 rs12173854 chr6:26371679 A/G cg16898833 chr6:26189333 HIST1H4D 0.76 6.58 0.34 1.84e-10 Autism spectrum disorder or schizophrenia; CRC cis rs1552244 0.882 rs13062917 chr3:10017032 T/A cg02579736 chr3:10068473 FANCD2;CIDECP 0.93 11.94 0.55 1.55e-27 Alzheimer's disease; CRC trans rs2832077 0.943 rs2832100 chr21:30175628 A/C cg14791747 chr16:20752902 THUMPD1 0.54 6.78 0.35 5.64e-11 Cognitive test performance; CRC cis rs4660214 0.666 rs7553009 chr1:39713113 C/T cg11070191 chr1:39582205 MACF1 0.36 5.73 0.3 2.23e-8 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs1143633 0.579 rs4849132 chr2:113673471 G/A cg06156847 chr2:113672199 IL1F7 0.49 7.48 0.38 6.69e-13 Allergic disease (asthma, hay fever or eczema); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg01655355 chr19:17982748 SLC5A5 0.39 6.09 0.32 3.18e-9 Response to antipsychotic treatment; CRC cis rs2032447 0.507 rs478349 chr6:25894057 T/C cg12310025 chr6:25882481 NA -0.81 -11.36 -0.53 1.85e-25 Intelligence (multi-trait analysis); CRC cis rs3087591 0.960 rs7212264 chr17:29454766 C/T cg24425628 chr17:29625626 OMG;NF1 0.79 14.21 0.62 4.4e-36 Hip circumference; CRC cis rs2976388 0.578 rs13263987 chr8:143827387 A/C cg24634471 chr8:143751801 JRK -0.49 -6.7 -0.35 9.05e-11 Urinary tract infection frequency; CRC cis rs654950 0.875 rs55865698 chr1:41986758 C/T cg06885757 chr1:42089581 HIVEP3 -0.34 -5.83 -0.31 1.29e-8 Airway imaging phenotypes; CRC cis rs9633740 1.000 rs7900536 chr10:82253701 G/T cg00277334 chr10:82204260 NA -0.5 -5.62 -0.3 4.01e-8 Post bronchodilator FEV1; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg26957173 chr10:75173848 ANXA7 0.39 6.28 0.33 1.09e-9 Liver disease severity in Alagille syndrome; CRC cis rs7215564 0.908 rs4243241 chr17:78660502 A/C cg09596252 chr17:78655493 RPTOR 0.54 5.73 0.3 2.25e-8 Myopia (pathological); CRC cis rs4711350 1.000 rs751727 chr6:33764158 A/G cg07979401 chr6:33739406 LEMD2 -0.49 -6.1 -0.32 2.94e-9 Schizophrenia; CRC cis rs7917772 0.503 rs7899576 chr10:104307504 G/A cg22532475 chr10:104410764 TRIM8 -0.36 -6.77 -0.35 5.98e-11 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC cis rs35110281 0.807 rs4818850 chr21:45028071 T/G cg01579765 chr21:45077557 HSF2BP -0.36 -6.76 -0.35 6.15e-11 Mean corpuscular volume; CRC cis rs9925964 0.933 rs749671 chr16:31088347 G/A cg02466173 chr16:30829666 NA 0.44 5.73 0.3 2.25e-8 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs951366 0.789 rs823121 chr1:205724302 A/G cg26354017 chr1:205819088 PM20D1 -0.72 -10.87 -0.51 1.04e-23 Menarche (age at onset); CRC cis rs4072980 0.545 rs7528185 chr1:38452059 C/T cg17077180 chr1:38461687 NA -0.37 -5.74 -0.3 2.15e-8 Coronary artery disease; CRC cis rs9660992 0.710 rs1668873 chr1:205235990 G/A cg21643547 chr1:205240462 TMCC2 -0.46 -7.42 -0.38 1.02e-12 Mean corpuscular volume;Mean platelet volume; CRC cis rs2204008 0.807 rs4123933 chr12:37973539 G/A cg26384229 chr12:38710491 ALG10B 0.69 9.14 0.45 6.75e-18 Bladder cancer; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg05501829 chr17:3749777 C17orf85 0.42 6.21 0.32 1.6e-9 Response to antipsychotic treatment; CRC trans rs4942242 0.663 rs9590779 chr13:44234886 A/G cg19169023 chr15:41853346 TYRO3 0.56 7.57 0.39 3.89e-13 Response to tocilizumab in rheumatoid arthritis; CRC cis rs2882667 0.931 rs10070021 chr5:138324706 A/G cg09476006 chr5:138032270 NA 0.42 7.09 0.36 8.17e-12 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs6942756 0.747 rs691124 chr7:129098439 A/G cg02491457 chr7:128862824 NA -0.59 -7.93 -0.4 3.44e-14 White matter hyperintensity burden; CRC cis rs17155006 0.664 rs411396 chr7:107744759 A/G cg05962710 chr7:107745446 LAMB4 -0.4 -7.12 -0.37 6.77e-12 Pneumococcal bacteremia; CRC cis rs798554 0.683 rs1636264 chr7:2864586 G/T cg13628971 chr7:2884303 GNA12 0.53 7.75 0.39 1.16e-13 Height; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg00665395 chr2:219575490 TTLL4 0.48 6.09 0.32 3.11e-9 Thyroid stimulating hormone; CRC cis rs1552244 1.000 rs9834980 chr3:10065528 G/A cg18598329 chr3:10140678 FANCD2;C3orf24 -0.88 -12.22 -0.56 1.48e-28 Alzheimer's disease; CRC cis rs10789491 1.000 rs601060 chr1:47139580 C/G cg15501359 chr1:47185051 KIAA0494 -0.66 -8.07 -0.41 1.35e-14 Response to hepatitis C treatment; CRC cis rs7552404 1.000 rs7516226 chr1:76234257 G/A cg03433033 chr1:76189801 ACADM 0.82 11.17 0.52 8.68e-25 Blood metabolite levels;Acylcarnitine levels; CRC cis rs7772486 0.790 rs1832362 chr6:146179955 C/T cg23711669 chr6:146136114 FBXO30 0.68 11.64 0.54 1.81e-26 Lobe attachment (rater-scored or self-reported); CRC cis rs17345786 0.911 rs10936707 chr3:101324063 G/A cg12386194 chr3:101231763 SENP7 0.53 6.93 0.36 2.24e-11 Colonoscopy-negative controls vs population controls; CRC cis rs35883536 1.000 rs35883536 chr1:101106534 G/A cg14515779 chr1:101123966 NA -0.43 -8.3 -0.42 2.75e-15 Monocyte count; CRC cis rs11785400 0.753 rs9694286 chr8:143737157 G/T cg24634471 chr8:143751801 JRK 0.49 6.57 0.34 1.98e-10 Schizophrenia; CRC cis rs2404602 0.716 rs56351018 chr15:76824591 T/C cg23625390 chr15:77176239 SCAPER 0.51 7.4 0.38 1.12e-12 Blood metabolite levels; CRC cis rs2242116 0.796 rs4683297 chr3:46973673 T/C cg27129171 chr3:47204927 SETD2 -0.63 -9.14 -0.45 6.63e-18 Birth weight; CRC cis rs9547692 1.000 rs2147167 chr13:37467404 G/A cg01493522 chr13:37497338 NA -0.49 -6.87 -0.35 3.16e-11 Coronary artery disease; CRC cis rs10256972 0.706 rs12701970 chr7:1121958 T/C cg03923535 chr7:1197113 ZFAND2A 0.61 8.46 0.42 9.01e-16 Longevity;Endometriosis; CRC cis rs10504229 0.683 rs16921937 chr8:58145010 A/G cg21724239 chr8:58056113 NA 0.5 6.79 0.35 5.1e-11 Developmental language disorder (linguistic errors); CRC cis rs780096 0.506 rs1647285 chr2:27714511 A/C cg27432699 chr2:27873401 GPN1 -0.52 -8.01 -0.4 1.99e-14 Total body bone mineral density; CRC cis rs8060686 0.641 rs12598256 chr16:68084021 G/A cg08314208 chr16:67682810 RLTPR -0.57 -6.09 -0.32 3.17e-9 HDL cholesterol;Metabolic syndrome; CRC cis rs4665809 0.590 rs35727620 chr2:26458364 G/A cg08067268 chr2:26466485 HADHB;HADHA 0.65 8.34 0.42 2e-15 Gut microbiome composition (summer); CRC cis rs1046896 0.538 rs3803771 chr17:80687758 G/A cg02711726 chr17:80685570 FN3KRP 0.41 6.52 0.34 2.68e-10 Glycated hemoglobin levels; CRC cis rs9660992 0.573 rs1172139 chr1:205213962 G/A cg21643547 chr1:205240462 TMCC2 -0.37 -6.06 -0.32 3.83e-9 Mean corpuscular volume;Mean platelet volume; CRC cis rs4243830 0.850 rs12744992 chr1:6601290 G/A cg05709478 chr1:6581295 PLEKHG5 -0.57 -6.75 -0.35 6.83e-11 Body mass index; CRC cis rs1223397 0.651 rs202019 chr6:13301790 A/C cg20827128 chr6:13274284 PHACTR1 0.38 5.75 0.3 2.07e-8 Blood pressure; CRC cis rs826838 1.000 rs11183747 chr12:38822595 A/G cg13010199 chr12:38710504 ALG10B -0.44 -5.81 -0.31 1.47e-8 Heart rate; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg13452400 chr2:7006280 CMPK2 0.46 6.25 0.33 1.3e-9 Anxiety disorder; CRC cis rs78456975 1.000 rs111935361 chr2:1554192 C/A cg26248373 chr2:1572462 NA -0.66 -7.1 -0.36 7.65e-12 Placebo response in major depressive disorder (% change in symptom score); CRC cis rs6502050 0.769 rs8068708 chr17:80120424 T/C cg09264619 chr17:80180166 NA -0.35 -5.93 -0.31 7.79e-9 Life satisfaction; CRC cis rs10870270 0.956 rs10781555 chr10:133745720 G/A cg17892150 chr10:133769511 PPP2R2D -0.74 -11.21 -0.53 6.17e-25 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; CRC cis rs5769765 0.773 rs9616391 chr22:50314573 C/T cg04121214 chr22:50244548 NA 0.42 5.63 0.3 3.84e-8 Schizophrenia; CRC cis rs7615952 0.512 rs34651730 chr3:125358640 T/C cg11143507 chr3:125485238 NA -0.58 -7.46 -0.38 7.69e-13 Blood pressure (smoking interaction); CRC cis rs1707322 0.964 rs785508 chr1:46527159 G/A cg03146154 chr1:46216737 IPP -0.52 -7.0 -0.36 1.42e-11 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs941408 0.515 rs1005556 chr19:2778543 G/T cg17333051 chr19:2783644 SGTA 0.43 6.68 0.35 1.02e-10 Total cholesterol levels; CRC trans rs4650994 0.525 rs10913567 chr1:178511941 A/C cg05059571 chr16:84539110 KIAA1609 -0.67 -9.45 -0.46 6.33e-19 HDL cholesterol levels;HDL cholesterol; CRC cis rs1448094 0.512 rs61930137 chr12:86242930 C/T cg00310523 chr12:86230176 RASSF9 0.33 5.62 0.3 3.97e-8 Major depressive disorder; CRC cis rs7122539 0.646 rs608248 chr11:66562248 C/T cg24851651 chr11:66362959 CCS -0.51 -9.69 -0.47 1.03e-19 HIV-1 susceptibility; CRC cis rs7705042 0.865 rs12655465 chr5:141522213 C/T cg07392085 chr5:141489673 NDFIP1 0.45 7.19 0.37 4.4e-12 Asthma; CRC cis rs2842992 0.747 rs1547093 chr6:160205991 C/A cg16489826 chr6:160211363 TCP1;MRPL18 0.48 6.06 0.32 3.76e-9 Age-related macular degeneration (geographic atrophy); CRC cis rs7772486 0.641 rs9390370 chr6:146357569 C/T cg05347473 chr6:146136440 FBXO30 0.49 7.1 0.36 7.87e-12 Lobe attachment (rater-scored or self-reported); CRC cis rs7659604 0.689 rs59131059 chr4:122666357 C/T cg06713675 chr4:122721982 EXOSC9 -0.4 -6.49 -0.34 3.2e-10 Type 2 diabetes; CRC cis rs36715 0.904 rs36701 chr5:127552529 C/T cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.58 6.74 0.35 7.03e-11 Breast cancer; CRC cis rs514406 0.708 rs536621 chr1:53309097 A/G cg25767906 chr1:53392781 SCP2 -0.53 -8.32 -0.42 2.4e-15 Monocyte count; CRC cis rs10504229 1.000 rs17217082 chr8:58180918 G/A cg05313129 chr8:58192883 C8orf71 -0.47 -6.99 -0.36 1.49e-11 Developmental language disorder (linguistic errors); CRC cis rs2836950 0.501 rs2836980 chr21:40687618 G/T cg06238570 chr21:40685208 BRWD1 -0.6 -8.64 -0.43 2.48e-16 Menarche (age at onset); CRC trans rs7968440 0.651 rs7309519 chr12:50652280 G/A cg00474734 chr12:53645975 MFSD5 0.37 5.96 0.31 6.47e-9 Fibrinogen; CRC cis rs28386778 0.897 rs8069969 chr17:61822223 T/G cg06873352 chr17:61820015 STRADA 0.76 14.29 0.62 2.31e-36 Prudent dietary pattern; CRC cis rs736408 0.507 rs6445531 chr3:52717282 T/C cg11645453 chr3:52864694 ITIH4 0.36 6.51 0.34 2.74e-10 Bipolar disorder; CRC cis rs10504229 0.639 rs17331850 chr8:58113538 G/T cg04204079 chr8:58130323 NA -0.45 -5.84 -0.31 1.27e-8 Developmental language disorder (linguistic errors); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg23817779 chr6:5261046 LYRM4;FARS2 0.41 6.46 0.34 3.75e-10 Liver disease severity in Alagille syndrome; CRC cis rs10504229 1.000 rs78953746 chr8:58170608 A/G cg02725872 chr8:58115012 NA -0.38 -6.42 -0.33 4.68e-10 Developmental language disorder (linguistic errors); CRC cis rs7923609 0.967 rs7912893 chr10:65162000 T/A cg08743896 chr10:65200160 JMJD1C -0.43 -6.2 -0.32 1.7e-9 Educational attainment;Liver enzyme levels (alkaline phosphatase); CRC cis rs6546550 0.901 rs10167142 chr2:70062360 T/C cg02498382 chr2:70120550 SNRNP27 -0.48 -7.83 -0.4 6.76e-14 Prevalent atrial fibrillation; CRC cis rs4363385 0.571 rs387930 chr1:153050058 A/G cg25856811 chr1:152973957 SPRR3 -0.24 -6.41 -0.33 5.08e-10 Inflammatory skin disease; CRC cis rs2658782 0.724 rs2605627 chr11:93259515 A/G cg15737290 chr11:93063684 CCDC67 0.57 7.85 0.4 6.09e-14 Pulmonary function decline; CRC cis rs2404602 0.647 rs11634266 chr15:77093461 A/G cg23625390 chr15:77176239 SCAPER -0.85 -13.7 -0.6 4.06e-34 Blood metabolite levels; CRC cis rs7258465 0.965 rs2561043 chr19:18622683 A/T cg06462663 chr19:18546047 ISYNA1 0.49 7.39 0.38 1.2e-12 Breast cancer; CRC cis rs73206853 0.764 rs67715513 chr12:110562910 G/A cg12870014 chr12:110450643 ANKRD13A 0.83 10.65 0.51 5.74e-23 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC cis rs1403694 0.695 rs3806689 chr3:186435077 A/G cg04611788 chr3:186434169 KNG1 -0.61 -9.13 -0.45 7.33e-18 Blood protein levels; CRC trans rs6011368 0.740 rs6062357 chr20:62892739 C/T cg13869341 chr1:15865 WASH5P 0.42 6.22 0.32 1.48e-9 Clozapine-induced cytotoxicity; CRC cis rs9925964 0.933 rs2359612 chr16:31103796 A/G cg10396673 chr16:31104726 VKORC1 -0.33 -5.6 -0.3 4.48e-8 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs1348850 0.507 rs10186934 chr2:178425998 T/C cg27490568 chr2:178487706 NA 0.55 5.64 0.3 3.67e-8 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs416603 0.967 rs11644184 chr16:11365104 G/A cg00044050 chr16:11439710 C16orf75 -0.56 -8.27 -0.41 3.43e-15 Type 1 diabetes; CRC cis rs1003719 0.762 rs4399800 chr21:38489478 G/T cg10648535 chr21:38446584 PIGP;TTC3 0.53 7.44 0.38 8.95e-13 Eye color traits; CRC cis rs6754311 0.773 rs4988226 chr2:136610598 A/G cg25344623 chr2:136566232 LCT 0.33 5.98 0.31 5.97e-9 Mosquito bite size; CRC cis rs1552244 0.572 rs3843008 chr3:10173742 C/T cg16606324 chr3:10149918 C3orf24 0.63 6.43 0.33 4.61e-10 Alzheimer's disease; CRC cis rs6460942 0.908 rs79175014 chr7:12245378 T/G cg06484146 chr7:12443880 VWDE -0.66 -6.56 -0.34 2.1e-10 Coronary artery disease; CRC cis rs9372498 0.536 rs72952761 chr6:118866758 A/C cg18833306 chr6:118973337 C6orf204 0.45 5.95 0.31 6.95e-9 Diastolic blood pressure; CRC cis rs7474896 0.537 rs1779068 chr10:38250785 G/A cg25427524 chr10:38739819 LOC399744 0.59 7.25 0.37 3.06e-12 Obesity (extreme); CRC cis rs4665809 0.590 rs66477033 chr2:26472497 T/C cg08067268 chr2:26466485 HADHB;HADHA 0.66 8.38 0.42 1.54e-15 Gut microbiome composition (summer); CRC cis rs8099014 0.906 rs4940696 chr18:56106596 C/T cg19312305 chr18:56117016 MIR122 0.45 6.88 0.35 3.11e-11 Platelet count; CRC cis rs4243830 0.850 rs10746502 chr1:6607199 A/G cg22792644 chr1:6614718 TAS1R1;NOL9 -0.83 -10.2 -0.49 2.05e-21 Body mass index; CRC cis rs2836974 0.932 rs2150415 chr21:40615367 A/G cg17971929 chr21:40555470 PSMG1 0.81 11.64 0.54 1.9e-26 Cognitive function; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg05573837 chr3:42696434 ZBTB47 -0.42 -6.77 -0.35 5.85e-11 Myopia (pathological); CRC cis rs12681288 0.676 rs7459467 chr8:999359 C/T cg15309053 chr8:964076 NA 0.44 7.39 0.38 1.24e-12 Schizophrenia; CRC cis rs3126085 0.877 rs7543541 chr1:152230878 T/C cg09127314 chr1:152161683 NA 0.47 5.99 0.31 5.61e-9 Atopic dermatitis; CRC cis rs9467711 0.651 rs13206443 chr6:26119245 C/T cg16898833 chr6:26189333 HIST1H4D 0.67 5.91 0.31 8.41e-9 Autism spectrum disorder or schizophrenia; CRC cis rs4700695 0.719 rs27077 chr5:65445342 C/T cg21114390 chr5:65439923 SFRS12 0.63 8.48 0.42 7.51e-16 Facial morphology (factor 19); CRC cis rs7762018 0.505 rs79938197 chr6:170059932 A/T cg24289452 chr6:170231220 NA -0.98 -7.04 -0.36 1.12e-11 Thiazide-induced adverse metabolic effects in hypertensive patients; CRC cis rs939584 0.932 rs2903490 chr2:651290 A/G cg03610516 chr2:642275 NA -0.42 -5.89 -0.31 9.71e-9 Body mass index; CRC cis rs17376456 0.825 rs72786702 chr5:93254656 A/C cg09848695 chr5:92956644 FAM172A;MIR2277 0.7 6.21 0.32 1.58e-9 Diabetic retinopathy; CRC cis rs1799949 0.602 rs4600503 chr17:41414324 C/G cg23758822 chr17:41437982 NA 0.79 13.4 0.59 5.5e-33 Menopause (age at onset); CRC cis rs6456156 1.000 rs6456156 chr6:167522300 T/C cg07513332 chr6:167530253 CCR6 0.45 7.99 0.4 2.32e-14 Primary biliary cholangitis; CRC cis rs11098499 0.909 rs7681978 chr4:120383775 T/C cg09307838 chr4:120376055 NA 0.71 10.92 0.52 6.75e-24 Corneal astigmatism; CRC cis rs2235642 0.750 rs2755185 chr16:1645827 A/G cg26528668 chr16:1614120 IFT140 0.38 5.97 0.31 6.12e-9 Coronary artery disease; CRC cis rs561341 0.941 rs4795664 chr17:30233467 C/T cg23018236 chr17:30244563 NA -0.61 -7.72 -0.39 1.44e-13 Hip circumference adjusted for BMI; CRC cis rs3789045 0.774 rs4252697 chr1:204501383 C/T cg17419461 chr1:204415978 PIK3C2B -0.55 -7.83 -0.4 6.98e-14 Educational attainment (college completion); CRC trans rs12699921 0.572 rs2030725 chr7:17868331 T/C cg15753394 chr6:17282781 RBM24 -0.36 -5.96 -0.31 6.37e-9 Fibrinogen levels; CRC cis rs7512552 0.803 rs9435997 chr1:150289496 G/A cg15654264 chr1:150340011 RPRD2 -0.57 -7.83 -0.4 6.56e-14 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); CRC trans rs7647973 0.710 rs6797299 chr3:49609794 G/T cg21665057 chr3:196295764 WDR53;FBXO45 -0.67 -6.94 -0.36 2.13e-11 Menarche (age at onset); CRC cis rs9308731 0.644 rs1439287 chr2:111871897 G/A cg18646521 chr2:111875858 NA 0.37 5.73 0.3 2.25e-8 Chronic lymphocytic leukemia; CRC cis rs28386778 0.562 rs721575 chr17:61782920 A/G cg11494091 chr17:61959527 GH2 -0.51 -8.45 -0.42 9.27e-16 Prudent dietary pattern; CRC cis rs11971779 0.941 rs4732368 chr7:139034207 A/C cg07862535 chr7:139043722 LUC7L2 1.05 12.7 0.57 2.45e-30 Diisocyanate-induced asthma; CRC cis rs17253792 0.915 rs79100824 chr14:56179606 C/T cg01858014 chr14:56050164 KTN1 -0.81 -6.11 -0.32 2.87e-9 Putamen volume; CRC cis rs477895 0.652 rs72920332 chr11:63947071 G/T cg18225595 chr11:63971243 STIP1 0.61 8.12 0.41 9.49e-15 Mean platelet volume; CRC cis rs801193 0.935 rs2286683 chr7:66129843 G/A cg00343986 chr7:65444356 GUSB -0.49 -7.23 -0.37 3.38e-12 Aortic root size; CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg00030291 chr7:8302094 ICA1 0.38 6.04 0.32 4.23e-9 Obesity-related traits; CRC cis rs4423214 0.840 rs1123007 chr11:71185357 G/A cg13043300 chr11:71146211 DHCR7 -0.44 -5.98 -0.31 5.98e-9 Vitamin D levels; CRC cis rs758324 0.947 rs2088719 chr5:131184439 C/T cg06307176 chr5:131281290 NA 0.42 6.14 0.32 2.32e-9 Alzheimer's disease in APOE e4- carriers; CRC cis rs4731207 0.698 rs727506 chr7:124462027 A/G cg23710748 chr7:124431027 NA 0.36 5.83 0.31 1.31e-8 Cutaneous malignant melanoma; CRC cis rs863345 0.604 rs2023632 chr1:158459034 T/C cg12129480 chr1:158549410 OR10X1 -0.29 -6.07 -0.32 3.49e-9 Pneumococcal bacteremia; CRC trans rs3008870 0.583 rs17497947 chr1:67457199 G/T cg01448155 chr10:3564782 NA 0.52 6.22 0.32 1.5e-9 Lymphocyte percentage of white cells; CRC cis rs2576037 0.583 rs9304336 chr18:44461687 T/C cg23996704 chr18:44553084 KATNAL2 -0.35 -7.09 -0.36 7.99e-12 Personality dimensions; CRC cis rs1129187 0.967 rs3805952 chr6:42937126 C/T cg05552183 chr6:42928497 GNMT 0.61 9.6 0.47 2.14e-19 Alzheimer's disease in APOE e4+ carriers; CRC cis rs644799 0.932 rs572015 chr11:95637416 T/A cg25622487 chr11:95524042 FAM76B;CEP57 0.73 11.16 0.52 9.7e-25 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs9837602 0.507 rs793455 chr3:99526135 C/A cg08350549 chr3:99591722 C3orf26;FILIP1L;MIR548G -0.4 -6.18 -0.32 1.85e-9 Breast cancer; CRC cis rs873946 0.586 rs12782567 chr10:134576709 C/G cg06453172 chr10:134556979 INPP5A 0.66 7.93 0.4 3.37e-14 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CRC cis rs12745968 0.589 rs6695638 chr1:93023486 G/A cg17283838 chr1:93427260 FAM69A -0.44 -6.02 -0.32 4.61e-9 Bipolar disorder and schizophrenia; CRC cis rs208515 0.525 rs10944871 chr6:66690306 A/G cg07460842 chr6:66804631 NA 0.96 12.25 0.56 1.13e-28 Exhaled nitric oxide levels; CRC cis rs1580019 0.587 rs1597555 chr7:32546118 T/G cg07520158 chr7:32535189 LSM5;AVL9 0.55 8.08 0.41 1.25e-14 Cognitive ability; CRC cis rs875971 1.000 rs937495 chr7:65779798 A/G cg18876405 chr7:65276391 NA -0.52 -8.84 -0.44 5.9e-17 Aortic root size; CRC cis rs270601 0.770 rs61352298 chr5:131600589 G/C cg18301423 chr5:131593218 PDLIM4 0.44 8.17 0.41 6.63e-15 Acylcarnitine levels; CRC cis rs3760982 1.000 rs11669175 chr19:44289824 A/G cg11993925 chr19:44307056 LYPD5 0.47 7.85 0.4 5.8e-14 Breast cancer (estrogen-receptor negative);Breast cancer; CRC cis rs7973719 0.865 rs1057225 chr12:7363574 C/G cg07052231 chr12:7363540 PEX5 0.51 8.06 0.41 1.42e-14 IgG glycosylation; CRC cis rs4700695 0.925 rs6449799 chr5:65394476 A/G cg21114390 chr5:65439923 SFRS12 -0.54 -6.87 -0.35 3.31e-11 Facial morphology (factor 19); CRC cis rs2153535 0.541 rs9405386 chr6:8458067 C/G cg07606381 chr6:8435919 SLC35B3 0.69 11.15 0.52 1.04e-24 Motion sickness; CRC cis rs1044826 0.642 rs4683464 chr3:139196961 C/T cg15131784 chr3:139108705 COPB2 0.39 5.65 0.3 3.5e-8 Obesity-related traits; CRC cis rs6502050 0.865 rs74480314 chr17:80117716 C/T cg22110888 chr17:80059540 CCDC57 0.4 6.45 0.34 3.95e-10 Life satisfaction; CRC cis rs9916302 0.904 rs4794807 chr17:37531718 T/A cg03013999 chr17:37608204 MED1 -0.47 -7.31 -0.37 2.1e-12 Glomerular filtration rate (creatinine); CRC cis rs2303759 0.709 rs10411679 chr19:49826480 A/T cg22307029 chr19:49891270 CCDC155 0.68 9.05 0.45 1.32e-17 Multiple sclerosis; CRC cis rs2228479 0.681 rs11641790 chr16:89961957 A/G cg06558623 chr16:89946397 TCF25 -0.64 -7.53 -0.38 4.81e-13 Skin colour saturation; CRC cis rs6540556 0.906 rs6540554 chr1:209932297 A/T cg23920097 chr1:209922102 NA 0.52 6.59 0.34 1.77e-10 Red blood cell count; CRC trans rs7267979 1.000 rs910997 chr20:25267301 G/A cg17903999 chr18:56338584 MALT1 -0.42 -7.0 -0.36 1.41e-11 Liver enzyme levels (alkaline phosphatase); CRC cis rs798554 0.591 rs1713913 chr7:2895627 C/T cg13628971 chr7:2884303 GNA12 0.42 6.41 0.33 5.05e-10 Height; CRC cis rs77861329 1.000 rs9811707 chr3:52190657 G/A cg08692210 chr3:52188851 WDR51A 0.86 8.11 0.41 1.03e-14 Macrophage inflammatory protein 1b levels; CRC cis rs2760061 0.655 rs686533 chr1:228119604 A/G cg18477163 chr1:228402036 OBSCN -0.35 -5.68 -0.3 2.97e-8 Diastolic blood pressure; CRC cis rs7542091 0.704 rs4133950 chr1:210044393 C/G cg22029157 chr1:209979665 IRF6 0.47 7.4 0.38 1.11e-12 Monobrow; CRC cis rs6662572 0.737 rs6429593 chr1:46505235 T/G cg08644498 chr1:46502608 NA 0.46 7.41 0.38 1.11e-12 Blood protein levels; CRC cis rs10949834 0.504 rs77541100 chr7:73555605 C/T cg07137043 chr7:73588983 EIF4H -0.63 -6.7 -0.35 9.13e-11 Verbal memory performance (residualized delayed recall change); CRC cis rs4474465 1.000 rs4474465 chr11:78204380 C/T cg27205649 chr11:78285834 NARS2 0.5 6.07 0.32 3.5e-9 Alzheimer's disease (survival time); CRC cis rs6502050 0.871 rs62079998 chr17:80077245 A/C cg13198984 chr17:80129470 CCDC57 -0.46 -7.98 -0.4 2.39e-14 Life satisfaction; CRC cis rs561341 1.000 rs1557731 chr17:30321567 T/G cg12193833 chr17:30244370 NA -0.63 -8.24 -0.41 4.13e-15 Hip circumference adjusted for BMI; CRC cis rs62432291 0.681 rs418859 chr6:159649695 A/T cg14500486 chr6:159655392 FNDC1 0.75 10.25 0.49 1.39e-21 Joint mobility (Beighton score); CRC cis rs10927875 0.632 rs10927863 chr1:16165247 C/A cg21385522 chr1:16154831 NA -1.12 -20.75 -0.75 9.51e-62 Dilated cardiomyopathy; CRC cis rs11190604 1.000 rs10883505 chr10:102280772 C/T cg07080220 chr10:102295463 HIF1AN 0.47 5.64 0.3 3.61e-8 Palmitoleic acid (16:1n-7) levels; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg24170415 chr4:185747632 ACSL1 0.43 6.16 0.32 2.1e-9 Response to antipsychotic treatment; CRC cis rs28386778 0.897 rs894406 chr17:61901657 A/G cg25654072 chr17:61904446 PSMC5;FTSJ3 0.72 11.25 0.53 4.67e-25 Prudent dietary pattern; CRC cis rs3771570 0.748 rs62186361 chr2:242168518 G/A cg21155796 chr2:242212141 HDLBP 0.57 6.21 0.32 1.6e-9 Prostate cancer; CRC cis rs9399135 0.660 rs4646868 chr6:135271946 A/G cg24558204 chr6:135376177 HBS1L 0.52 7.93 0.4 3.48e-14 Red blood cell count; CRC cis rs4728142 0.738 rs3807306 chr7:128580680 A/C cg06630958 chr7:128577819 IRF5 0.4 6.96 0.36 1.82e-11 Inflammatory bowel disease;Systemic lupus erythematosus;Ulcerative colitis; CRC cis rs6500395 1.000 rs1486412 chr16:48651750 A/T cg04672837 chr16:48644449 N4BP1 0.44 6.47 0.34 3.62e-10 Response to tocilizumab in rheumatoid arthritis; CRC cis rs2153535 0.580 rs5001130 chr6:8442298 G/A cg21535247 chr6:8435926 SLC35B3 0.47 7.12 0.37 6.79e-12 Motion sickness; CRC cis rs6456156 0.586 rs10946208 chr6:167459596 C/T cg23791538 chr6:167370224 RNASET2 -0.38 -5.71 -0.3 2.47e-8 Primary biliary cholangitis; CRC cis rs12024301 0.557 rs6693049 chr1:183624260 G/A cg11505048 chr1:183622726 RGL1;APOBEC4 0.78 6.93 0.36 2.18e-11 Peripheral arterial disease (traffic-related air pollution interaction); CRC trans rs6472235 0.807 rs60667481 chr8:66928360 G/A cg07884673 chr3:53033167 SFMBT1 -0.45 -6.03 -0.32 4.47e-9 Myopia (pathological);Plateletcrit; CRC cis rs13256369 0.851 rs11249890 chr8:8565245 G/T cg17143192 chr8:8559678 CLDN23 0.52 6.68 0.35 9.94e-11 Obesity-related traits; CRC cis rs933688 1.000 rs9293568 chr5:90737845 C/T cg02339078 chr5:90679543 LOC100129716;ARRDC3 0.88 13.58 0.6 1.14e-33 Smoking behavior; CRC cis rs7772486 0.840 rs2814867 chr6:146334030 C/A cg23711669 chr6:146136114 FBXO30 0.67 11.37 0.53 1.78e-25 Lobe attachment (rater-scored or self-reported); CRC cis rs9807841 0.544 rs10407692 chr19:10770783 A/G cg17710535 chr19:10819994 QTRT1 0.45 6.54 0.34 2.33e-10 Inflammatory skin disease; CRC cis rs6951245 1.000 rs78861357 chr7:1095418 C/T cg18402987 chr7:1209562 NA 0.67 7.15 0.37 5.54e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs2204008 0.774 rs3910796 chr12:38230660 G/T cg13010199 chr12:38710504 ALG10B 0.46 5.8 0.3 1.57e-8 Bladder cancer; CRC cis rs4665809 0.652 rs6728090 chr2:26524726 C/T cg04944784 chr2:26401820 FAM59B -0.57 -7.46 -0.38 7.85e-13 Gut microbiome composition (summer); CRC cis rs3858526 0.523 rs10838749 chr11:5884246 A/G cg02574844 chr11:5959923 NA -0.5 -7.23 -0.37 3.34e-12 DNA methylation (variation); CRC cis rs6960043 0.791 rs2191346 chr7:15053878 C/G cg19272540 chr7:15055459 NA -0.22 -5.78 -0.3 1.76e-8 Type 2 diabetes; CRC cis rs10242455 0.702 rs73713507 chr7:99138603 G/A cg18809830 chr7:99032528 PTCD1 -1.32 -9.15 -0.45 6.31e-18 Blood metabolite levels; CRC trans rs7824557 0.564 rs2736290 chr8:11234298 C/T cg16141378 chr3:129829833 LOC729375 0.4 6.05 0.32 3.86e-9 Retinal vascular caliber; CRC cis rs7918232 0.607 rs1755401 chr10:27405763 A/C cg14240646 chr10:27532245 ACBD5 -0.89 -8.98 -0.44 2.19e-17 Breast cancer; CRC cis rs9814567 1.000 rs6802654 chr3:134217072 C/T cg06109529 chr3:134205091 CEP63;ANAPC13 -0.81 -12.26 -0.56 1e-28 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs12048904 0.964 rs12027668 chr1:101330984 G/A cg00063077 chr1:101360652 SLC30A7;EXTL2 0.52 7.6 0.39 3.19e-13 Multiple sclerosis; CRC cis rs1799949 0.965 rs12950779 chr17:41306523 C/T cg05368731 chr17:41323189 NBR1 0.69 10.5 0.5 1.97e-22 Menopause (age at onset); CRC trans rs7824557 0.527 rs2736298 chr8:11235136 C/G cg06636001 chr8:8085503 FLJ10661 -0.45 -6.79 -0.35 5.15e-11 Retinal vascular caliber; CRC cis rs4509693 0.941 rs7914169 chr10:102495725 A/G cg23167259 chr10:102495509 NA -0.45 -6.45 -0.34 3.9e-10 Alzheimer's disease; CRC cis rs9902453 1.000 rs4581755 chr17:28427898 A/G cg26525008 chr17:28256777 EFCAB5;SSH2 0.59 8.92 0.44 3.23e-17 Coffee consumption (cups per day); CRC trans rs5756813 0.782 rs3171656 chr22:38172213 G/A cg19894588 chr14:64061835 NA -0.58 -7.8 -0.4 8.15e-14 Optic cup area;Vertical cup-disc ratio; CRC cis rs6558174 0.630 rs6558176 chr8:22522502 C/T cg03733263 chr8:22462867 KIAA1967 -0.5 -7.07 -0.36 9.19e-12 Breast cancer; CRC cis rs66573146 1.000 rs28384174 chr4:6961107 G/T cg00086871 chr4:6988644 TBC1D14 0.8 6.25 0.33 1.28e-9 Granulocyte percentage of myeloid white cells; CRC trans rs2710642 0.821 rs56373728 chr2:63095792 G/A cg05376469 chr2:102649931 NA -0.38 -6.21 -0.32 1.57e-9 LDL cholesterol levels;LDL cholesterol; CRC cis rs72781680 0.821 rs17045981 chr2:24109316 A/G cg08917208 chr2:24149416 ATAD2B 0.53 6.31 0.33 8.99e-10 Lymphocyte counts; CRC cis rs2072510 0.966 rs11108372 chr12:96394517 A/G cg22491680 chr12:96389547 HAL -0.39 -6.08 -0.32 3.36e-9 Metabolite levels (small molecules and protein measures); CRC cis rs7666738 0.723 rs35327100 chr4:98977788 C/A cg05340658 chr4:99064831 C4orf37 0.6 9.35 0.46 1.41e-18 Colonoscopy-negative controls vs population controls; CRC cis rs7666738 0.791 rs13120773 chr4:98972589 C/T cg17366294 chr4:99064904 C4orf37 0.44 7.44 0.38 8.98e-13 Colonoscopy-negative controls vs population controls; CRC cis rs7843479 0.601 rs9969551 chr8:21860007 T/C cg16476235 chr8:21771668 DOK2 0.41 6.89 0.36 2.84e-11 Mean corpuscular volume; CRC cis rs7811142 0.943 rs3900792 chr7:100004577 C/G cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.12 16.89 0.68 1.63e-46 Platelet count; CRC cis rs1799949 1.000 rs36036395 chr17:41181297 T/C cg05368731 chr17:41323189 NBR1 0.69 10.12 0.49 3.81e-21 Menopause (age at onset); CRC cis rs7223966 1.000 rs11079511 chr17:61858537 C/G cg05941027 chr17:61774174 LIMD2 0.33 5.64 0.3 3.65e-8 Hip circumference adjusted for BMI;Body mass index; CRC cis rs1983891 0.865 rs10947980 chr6:41525739 A/G cg20194872 chr6:41519635 FOXP4 0.43 5.85 0.31 1.17e-8 Prostate cancer; CRC cis rs6840360 0.642 rs7666571 chr4:152443273 C/T cg09659197 chr4:152720779 NA 0.32 6.43 0.33 4.4e-10 Intelligence (multi-trait analysis); CRC cis rs7119 0.717 rs12911854 chr15:77817288 T/C cg10437265 chr15:77819839 NA 0.69 12.73 0.57 1.9e-30 Type 2 diabetes; CRC cis rs2549003 0.933 rs7719499 chr5:131814091 C/G cg02551604 chr5:131831745 NA -0.54 -8.13 -0.41 9.05e-15 Asthma (sex interaction); CRC cis rs16975963 0.843 rs241954 chr19:38277530 C/T cg15135657 chr19:38346511 NA -0.43 -5.77 -0.3 1.87e-8 Longevity; CRC cis rs13191362 0.507 rs7772787 chr6:163190981 C/T cg06582575 chr6:163149167 PACRG;PARK2 0.48 7.71 0.39 1.47e-13 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs916888 0.821 rs199514 chr17:44856881 G/A cg17911788 chr17:44343683 NA 0.57 6.87 0.35 3.18e-11 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs2075371 1.000 rs2244694 chr7:133987093 C/T cg11752832 chr7:134001865 SLC35B4 0.5 7.75 0.39 1.19e-13 Mean platelet volume; CRC cis rs13256369 1.000 rs12550458 chr8:8567832 G/A cg06636001 chr8:8085503 FLJ10661 0.49 6.2 0.32 1.67e-9 Obesity-related traits; CRC cis rs9549260 0.755 rs17061450 chr13:41183716 G/A cg21288729 chr13:41239152 FOXO1 0.41 6.44 0.33 4.29e-10 Red blood cell count; CRC cis rs4481887 0.927 rs10888340 chr1:248440381 C/T cg00666640 chr1:248458726 OR2T12 0.56 9.96 0.48 1.32e-20 Common traits (Other); CRC cis rs79349575 0.783 rs28409394 chr17:46998118 T/C cg00947319 chr17:47005597 UBE2Z -0.34 -5.9 -0.31 9.06e-9 Type 2 diabetes; CRC cis rs28386778 0.897 rs2727295 chr17:61887693 C/T cg23090583 chr17:61904693 PSMC5;FTSJ3 0.97 19.0 0.72 7.38e-55 Prudent dietary pattern; CRC cis rs1865760 0.516 rs9393683 chr6:26066198 A/G cg18357526 chr6:26021779 HIST1H4A 0.43 6.05 0.32 4.01e-9 Height; CRC trans rs10242455 0.557 rs45492501 chr7:99047030 T/A cg09045935 chr12:6379348 NA 1.13 9.23 0.45 3.42e-18 Blood metabolite levels; CRC cis rs9926296 0.585 rs8045232 chr16:89857548 A/G cg04287289 chr16:89883240 FANCA 0.82 14.65 0.63 8.85e-38 Vitiligo; CRC cis rs7917772 0.582 rs10786691 chr10:104364652 G/A cg11453585 chr10:104263688 ACTR1A;SUFU 0.82 15.29 0.64 3.08e-40 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC cis rs2067615 0.579 rs10861665 chr12:107193836 T/C cg13491945 chr12:107078410 RFX4 0.35 6.0 0.31 5.34e-9 Heart rate; CRC cis rs1023500 0.573 rs133370 chr22:42465260 T/C cg15557168 chr22:42548783 NA -0.38 -6.63 -0.34 1.38e-10 Schizophrenia; CRC cis rs4713118 0.614 rs9468209 chr6:27694421 C/T cg12172441 chr6:28176163 NA 0.43 6.13 0.32 2.55e-9 Parkinson's disease; CRC trans rs2303319 0.504 rs56009150 chr2:162598582 T/C cg20024234 chr21:43431083 ZNF295 -0.68 -6.17 -0.32 2.02e-9 Cognitive function; CRC cis rs1448094 0.511 rs59858864 chr12:86166404 G/A cg25456477 chr12:86230367 RASSF9 0.37 6.16 0.32 2.13e-9 Major depressive disorder; CRC cis rs9372498 0.536 rs9489436 chr6:118873817 A/C cg24463073 chr6:118973353 C6orf204 0.52 6.91 0.36 2.52e-11 Diastolic blood pressure; CRC cis rs10751667 0.666 rs4074234 chr11:977715 C/G cg01483505 chr11:975446 AP2A2 0.46 7.66 0.39 2.11e-13 Alzheimer's disease (late onset); CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg15353389 chr12:120525027 CCDC64 0.47 6.02 0.31 4.77e-9 Thyroid stimulating hormone; CRC trans rs11252926 0.604 rs12359454 chr10:568081 T/C cg00953403 chr17:74099816 EXOC7 -0.47 -6.95 -0.36 1.98e-11 Psychosis in Alzheimer's disease; CRC cis rs1639906 0.895 rs34255795 chr7:2207416 A/G cg19897017 chr7:2163380 MAD1L1 -0.6 -8.92 -0.44 3.34e-17 Colonoscopy-negative controls vs population controls; CRC cis rs5769765 0.862 rs9616380 chr22:50312225 T/C cg04121214 chr22:50244548 NA 0.42 5.89 0.31 9.4e-9 Schizophrenia; CRC cis rs55702914 0.837 rs2195507 chr2:198172336 T/C cg03934865 chr2:198174659 NA -0.39 -6.81 -0.35 4.56e-11 Major depression and alcohol dependence; CRC cis rs28386778 0.966 rs2008053 chr17:61954918 G/C cg11494091 chr17:61959527 GH2 0.59 10.19 0.49 2.27e-21 Prudent dietary pattern; CRC trans rs10504229 0.954 rs114134184 chr8:58181969 G/A cg04077850 chr5:125800366 GRAMD3 0.37 6.27 0.33 1.15e-9 Developmental language disorder (linguistic errors); CRC cis rs10979 0.964 rs9321922 chr6:143895231 A/G cg25407410 chr6:143891975 LOC285740 -0.84 -13.84 -0.61 1.22e-34 Hypospadias; CRC cis rs669446 0.533 rs28833034 chr1:44212942 A/G cg12908607 chr1:44402522 ARTN -0.35 -6.04 -0.32 4.1e-9 Amyotrophic lateral sclerosis (age of onset); CRC cis rs11098499 0.697 rs6832410 chr4:120296800 A/G cg24375607 chr4:120327624 NA 0.51 7.86 0.4 5.5e-14 Corneal astigmatism; CRC cis rs7772486 0.790 rs2253880 chr6:146200774 T/C cg23711669 chr6:146136114 FBXO30 0.67 11.48 0.53 6.99e-26 Lobe attachment (rater-scored or self-reported); CRC cis rs11711311 1.000 rs9828099 chr3:113518402 T/C cg15478005 chr3:113465772 ATP6V1A;NAA50 0.43 5.88 0.31 9.92e-9 IgG glycosylation; CRC cis rs1799949 1.000 rs11653069 chr17:41283377 C/T cg01879757 chr17:41196368 BRCA1 -0.43 -6.61 -0.34 1.54e-10 Menopause (age at onset); CRC cis rs2075371 0.829 rs11770764 chr7:134003308 T/C cg11752832 chr7:134001865 SLC35B4 0.44 6.6 0.34 1.65e-10 Mean platelet volume; CRC trans rs2727020 0.514 rs4980444 chr11:49550764 T/A cg15704280 chr7:45808275 SEPT13 -0.95 -17.56 -0.7 3.48e-49 Coronary artery disease; CRC cis rs7927771 0.864 rs11600581 chr11:47448497 T/C cg20307385 chr11:47447363 PSMC3 -0.62 -9.19 -0.45 4.48e-18 Subjective well-being; CRC cis rs10464366 0.544 rs12701697 chr7:39182165 C/T cg18850127 chr7:39170497 POU6F2 0.57 7.56 0.38 4e-13 IgG glycosylation; CRC cis rs877282 0.898 rs36064821 chr10:760952 C/T cg17470449 chr10:769945 NA 0.64 8.35 0.42 1.98e-15 Uric acid levels; CRC trans rs9784649 0.760 rs72755820 chr5:25066181 G/A cg11038491 chr20:34638489 LOC647979 -0.58 -7.4 -0.38 1.12e-12 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs2302190 0.882 rs8067183 chr17:56462023 G/A cg25885038 chr17:56607967 SEPT4 -0.37 -5.74 -0.3 2.15e-8 Vitamin D levels; CRC cis rs9611565 0.694 rs202616 chr22:41822221 C/G cg06481639 chr22:41940642 POLR3H 0.51 5.63 0.3 3.96e-8 Vitiligo; CRC cis rs2075371 0.933 rs1421480 chr7:133958114 A/C cg20476274 chr7:133979776 SLC35B4 0.78 14.1 0.61 1.18e-35 Mean platelet volume; CRC cis rs4481887 0.800 rs4514268 chr1:248444600 T/G cg00666640 chr1:248458726 OR2T12 0.49 8.52 0.43 5.98e-16 Common traits (Other); CRC cis rs7833790 0.660 rs67666182 chr8:82772037 A/G cg17211192 chr8:82754475 SNX16 0.47 6.62 0.34 1.47e-10 Diastolic blood pressure; CRC cis rs2477686 0.526 rs1998760 chr1:2397136 C/T cg07700843 chr1:2391317 NA -0.48 -7.49 -0.38 6.51e-13 Non-obstructive azoospermia; CRC cis rs9322193 0.923 rs9371207 chr6:150179223 A/G cg07701084 chr6:150067640 NUP43 0.53 7.23 0.37 3.33e-12 Lung cancer; CRC trans rs1005277 0.579 rs1740742 chr10:38518860 C/T cg17830980 chr10:43048298 ZNF37B -0.57 -9.68 -0.47 1.16e-19 Extrinsic epigenetic age acceleration; CRC cis rs4631830 0.869 rs4131357 chr10:51537292 C/A cg20129853 chr10:51489980 NA -0.36 -5.92 -0.31 8.09e-9 Prostate-specific antigen levels; CRC cis rs11098499 0.820 rs28578366 chr4:120536905 A/G cg24375607 chr4:120327624 NA -0.53 -8.01 -0.4 1.96e-14 Corneal astigmatism; CRC cis rs28386778 0.897 rs2028567 chr17:61915326 G/A cg06601766 chr17:61851465 DDX42;CCDC47 0.45 6.12 0.32 2.71e-9 Prudent dietary pattern; CRC cis rs9649213 0.593 rs6947340 chr7:97912241 A/G cg00277769 chr7:97922759 BAIAP2L1 0.6 10.74 0.51 2.91e-23 Prostate cancer (SNP x SNP interaction); CRC cis rs875971 0.862 rs778684 chr7:65836403 A/T cg18252515 chr7:66147081 NA -0.4 -5.78 -0.3 1.71e-8 Aortic root size; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg14544983 chr19:47248940 FKRP;STRN4 0.51 7.15 0.37 5.82e-12 Anxiety disorder; CRC cis rs1005277 0.579 rs1780139 chr10:38503018 C/T cg17219203 chr10:38645113 HSD17B7P2 -0.41 -5.93 -0.31 7.61e-9 Extrinsic epigenetic age acceleration; CRC cis rs270601 0.770 rs10463891 chr5:131597392 C/T cg27615366 chr5:131592974 PDLIM4 -0.36 -7.02 -0.36 1.25e-11 Acylcarnitine levels; CRC cis rs990171 0.607 rs2192752 chr2:102769373 A/C cg22835712 chr2:102737379 NA -0.45 -5.72 -0.3 2.35e-8 Lymphocyte counts; CRC cis rs2067615 0.524 rs4964186 chr12:107080235 C/T cg15890332 chr12:107067104 RFX4 0.32 5.67 0.3 3.2e-8 Heart rate; CRC cis rs9488822 0.676 rs11153594 chr6:116354591 A/G cg26893134 chr6:116381904 FRK -0.29 -8.5 -0.42 6.79e-16 Cholesterol, total;LDL cholesterol; CRC cis rs10504229 0.593 rs76922080 chr8:57985837 C/G cg21724239 chr8:58056113 NA 0.77 9.39 0.46 1.06e-18 Developmental language disorder (linguistic errors); CRC cis rs8031584 0.958 rs34294266 chr15:31246840 A/G cg08704250 chr15:31115839 NA -0.44 -7.96 -0.4 2.75e-14 Huntington's disease progression; CRC cis rs9858542 1.000 rs9823546 chr3:49705512 T/A cg07274523 chr3:49395745 GPX1 0.48 6.18 0.32 1.91e-9 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs1401999 1.000 rs7632670 chr3:183713877 A/G cg05044414 chr3:183734942 ABCC5 0.48 8.31 0.42 2.55e-15 Anterior chamber depth; CRC cis rs79149102 0.579 rs61166993 chr15:75306644 C/A cg17294928 chr15:75287854 SCAMP5 -0.55 -5.83 -0.31 1.35e-8 Lung cancer; CRC cis rs763121 0.853 rs4821808 chr22:39065739 A/G cg06022373 chr22:39101656 GTPBP1 0.8 12.67 0.57 3.21e-30 Menopause (age at onset); CRC cis rs6951245 1.000 rs113066613 chr7:1094128 T/C cg22907277 chr7:1156413 C7orf50 0.73 7.7 0.39 1.59e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs10782582 0.609 rs10873797 chr1:76377191 G/T cg10523679 chr1:76189770 ACADM -0.42 -5.96 -0.31 6.32e-9 Daytime sleep phenotypes; CRC cis rs172166 0.637 rs1225597 chr6:28162087 C/T cg10876282 chr6:28092338 ZSCAN16 0.49 6.78 0.35 5.55e-11 Cardiac Troponin-T levels; CRC cis rs4908768 0.539 rs7526171 chr1:8650185 T/C cg20416874 chr1:8611966 RERE -0.42 -5.9 -0.31 8.86e-9 Neuroticism (multi-trait analysis);Subjective well-being (multi-trait analysis); CRC cis rs460214 0.528 rs4817954 chr21:40023857 C/T cg05519781 chr21:40033154 ERG -0.42 -5.98 -0.31 5.67e-9 Response to cognitive-behavioural therapy in anxiety disorder; CRC cis rs10504229 0.683 rs11786845 chr8:58133642 T/C cg21724239 chr8:58056113 NA 0.48 6.57 0.34 1.92e-10 Developmental language disorder (linguistic errors); CRC cis rs6952809 0.532 rs6952152 chr7:2440912 G/A cg23289794 chr7:2394357 EIF3B -0.79 -9.51 -0.46 4.25e-19 Multiple sclerosis; CRC cis rs9326248 0.689 rs4516002 chr11:116999059 A/G cg26566898 chr11:117069891 TAGLN 0.41 6.46 0.34 3.82e-10 Blood protein levels; CRC cis rs6921919 0.583 rs7740351 chr6:28399412 A/C cg21251018 chr6:28226885 NKAPL 0.39 5.98 0.31 5.98e-9 Autism spectrum disorder or schizophrenia; CRC trans rs61931739 0.500 rs11053272 chr12:34547020 C/G cg26384229 chr12:38710491 ALG10B 0.68 8.8 0.44 7.69e-17 Morning vs. evening chronotype; CRC cis rs8180040 0.966 rs11925823 chr3:47443065 C/G cg10298567 chr3:47292165 KIF9 -0.35 -5.83 -0.31 1.33e-8 Colorectal cancer; CRC cis rs826838 1.000 rs10880785 chr12:38655405 T/G cg26384229 chr12:38710491 ALG10B 0.72 10.23 0.49 1.61e-21 Heart rate; CRC cis rs6089584 0.888 rs6142927 chr20:60605848 A/G cg18761221 chr20:60518478 NA 0.54 8.31 0.42 2.62e-15 Body mass index; CRC cis rs6951245 1.000 rs76833820 chr7:1070278 A/T cg26224354 chr7:1096374 C7orf50;GPR146 -0.88 -11.08 -0.52 1.89e-24 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC trans rs10435719 0.753 rs9694940 chr8:11789858 G/C cg08975724 chr8:8085496 FLJ10661 0.4 6.01 0.31 4.86e-9 C-reactive protein levels or triglyceride levels (pleiotropy); CRC cis rs7215564 0.908 rs35725122 chr17:78663275 A/T cg09596252 chr17:78655493 RPTOR 0.54 6.08 0.32 3.26e-9 Myopia (pathological); CRC cis rs10256972 0.616 rs6957733 chr7:1106327 T/G cg04025307 chr7:1156635 C7orf50 0.38 5.71 0.3 2.48e-8 Longevity;Endometriosis; CRC trans rs877282 0.891 rs34383514 chr10:800181 T/C cg22713356 chr15:30763199 NA 1.34 16.61 0.68 2.03e-45 Uric acid levels; CRC cis rs17608059 0.504 rs11656981 chr17:13978777 A/G cg11395062 chr17:14139857 CDRT15 0.64 10.56 0.5 1.23e-22 Temperament; CRC cis rs1448094 0.967 rs11117116 chr12:86331087 A/T cg18827107 chr12:86230957 RASSF9 -0.37 -6.1 -0.32 2.98e-9 Major depressive disorder; CRC cis rs1448094 0.512 rs10863086 chr12:86244225 G/A cg00310523 chr12:86230176 RASSF9 0.33 5.62 0.3 3.97e-8 Major depressive disorder; CRC cis rs1799949 1.000 rs8176296 chr17:41203591 T/C cg01879757 chr17:41196368 BRCA1 -0.41 -6.26 -0.33 1.24e-9 Menopause (age at onset); CRC cis rs7249142 0.573 rs2238668 chr19:19282597 A/G cg26504305 chr19:19281019 LOC729991-MEF2B;MEF2B -0.44 -8.85 -0.44 5.31e-17 IgG glycosylation; CRC cis rs10896135 0.526 rs12795774 chr11:66381517 T/C cg24851651 chr11:66362959 CCS -0.5 -8.23 -0.41 4.34e-15 Bipolar disorder; CRC cis rs9914988 0.943 rs7215000 chr17:27088436 C/T cg16670446 chr17:27188758 MIR451;MIR144 0.55 8.58 0.43 3.81e-16 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs17376456 0.825 rs13165400 chr5:93091427 G/A cg25358565 chr5:93447407 FAM172A 1.0 9.41 0.46 9.08e-19 Diabetic retinopathy; CRC cis rs13108904 0.870 rs1564508 chr4:1244879 A/G cg00684032 chr4:1343700 KIAA1530 0.41 6.42 0.33 4.63e-10 Obesity-related traits; CRC cis rs10464366 0.614 rs62442213 chr7:39146933 C/T cg20302533 chr7:39170763 POU6F2 0.41 5.63 0.3 3.79e-8 IgG glycosylation; CRC cis rs6662572 0.737 rs10789476 chr1:46305362 G/A cg03123370 chr1:45965343 CCDC163P;MMACHC -0.46 -5.82 -0.31 1.43e-8 Blood protein levels; CRC cis rs1552172 0.922 rs12724816 chr1:145639324 G/T cg11743829 chr1:145714124 CD160 -0.42 -6.38 -0.33 6.15e-10 Breast cancer; CRC cis rs4689592 0.503 rs10516184 chr4:7060959 C/T cg06697600 chr4:7070879 GRPEL1 -0.52 -6.81 -0.35 4.57e-11 Monocyte percentage of white cells; CRC cis rs9549367 0.789 rs9577218 chr13:113894911 A/G cg00898013 chr13:113819073 PROZ -0.43 -6.36 -0.33 6.66e-10 Platelet distribution width; CRC cis rs3806843 1.000 rs3733707 chr5:140181892 T/C cg19875535 chr5:140030758 IK 0.62 10.16 0.49 2.9e-21 Depressive symptoms (multi-trait analysis); CRC cis rs2153535 0.580 rs6929206 chr6:8447961 A/G cg21535247 chr6:8435926 SLC35B3 0.49 7.37 0.38 1.43e-12 Motion sickness; CRC cis rs769267 0.930 rs10402451 chr19:19608537 A/G cg02546618 chr19:19431379 KIAA0892;SF4 0.45 6.11 0.32 2.75e-9 Tonsillectomy; CRC trans rs7615952 0.546 rs111812401 chr3:125361495 G/A cg16558177 chr4:4109446 NA -0.56 -6.7 -0.35 8.94e-11 Blood pressure (smoking interaction); CRC cis rs597539 0.616 rs473997 chr11:68639481 C/T cg06028808 chr11:68637592 NA 0.41 6.24 0.33 1.36e-9 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs7487075 1.000 rs7976280 chr12:46800825 G/A cg22049899 chr12:47219821 SLC38A4 0.33 6.53 0.34 2.53e-10 Itch intensity from mosquito bite; CRC cis rs7772486 0.875 rs6914813 chr6:146397798 A/G cg13319975 chr6:146136371 FBXO30 -0.39 -6.0 -0.31 5.31e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs10540 0.915 rs12419209 chr11:494510 T/C cg15790184 chr11:494944 RNH1 0.6 6.18 0.32 1.85e-9 Body mass index; CRC trans rs16957091 0.528 rs72713795 chr15:43141628 T/A cg07673103 chr8:74277181 NA 0.55 6.0 0.31 5.09e-9 MGMT methylation in smokers; CRC cis rs7647973 1.000 rs11928090 chr3:49604904 G/A cg07690219 chr3:49449608 TCTA;RHOA -0.51 -5.93 -0.31 7.5e-9 Menarche (age at onset); CRC cis rs1023500 0.573 rs4822088 chr22:42470589 G/C cg04733989 chr22:42467013 NAGA 0.6 9.09 0.45 9.84e-18 Schizophrenia; CRC cis rs524281 0.692 rs2302884 chr11:65824084 C/T cg16950941 chr11:66035639 RAB1B -0.55 -7.35 -0.38 1.56e-12 Electroencephalogram traits; CRC cis rs10540 1.000 rs61877760 chr11:506596 C/T cg03934478 chr11:495069 RNH1 0.7 7.81 0.4 7.99e-14 Body mass index; CRC cis rs4819052 0.807 rs28715237 chr21:46673768 C/G cg02159808 chr21:46707872 POFUT2;LOC642852 0.53 6.93 0.36 2.17e-11 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs753778 0.667 rs10103731 chr8:142206068 C/T cg18755752 chr8:142205143 DENND3 -0.64 -10.53 -0.5 1.56e-22 Reticulocyte fraction of red cells;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; CRC cis rs926938 0.783 rs10858053 chr1:115297374 A/G cg12756093 chr1:115239321 AMPD1 -0.7 -10.81 -0.51 1.61e-23 Autism; CRC cis rs3008870 1.000 rs975451 chr1:67480060 T/C cg08660285 chr1:67390436 MIER1;WDR78 1.04 15.42 0.65 9.52e-41 Lymphocyte percentage of white cells; CRC cis rs7408868 1.000 rs2074622 chr19:15277620 G/C cg14696996 chr19:15285081 NOTCH3 0.96 9.0 0.44 1.82e-17 Pulse pressure; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg02619805 chr19:5623015 SAFB2;SAFB 0.51 7.14 0.37 6e-12 Anxiety disorder; CRC cis rs75804782 0.641 rs72983853 chr2:239324210 C/T cg18131467 chr2:239335373 ASB1 -0.7 -6.2 -0.32 1.67e-9 Morning vs. evening chronotype;Chronotype; CRC cis rs11098499 0.954 rs12499324 chr4:120393786 C/T cg09307838 chr4:120376055 NA 0.71 11.01 0.52 3.26e-24 Corneal astigmatism; CRC cis rs7945705 0.869 rs2742471 chr11:9003953 C/T cg21881798 chr11:8931708 C11orf17;ST5 -0.68 -11.35 -0.53 2.04e-25 Hemoglobin concentration; CRC cis rs1712517 0.873 rs1163083 chr10:105038455 T/A cg05636881 chr10:105038444 INA 0.49 8.88 0.44 4.51e-17 Migraine; CRC trans rs12495832 0.778 rs79133147 chr3:147934169 A/T cg10221266 chr7:153579447 NA 0.53 6.0 0.31 5.26e-9 Chin dimples; CRC cis rs908922 0.676 rs491077 chr1:152519570 C/A cg23254163 chr1:152506842 NA 0.45 8.87 0.44 4.86e-17 Hair morphology; CRC cis rs950776 0.667 rs57728226 chr15:78929350 G/C cg06917634 chr15:78832804 PSMA4 0.55 8.03 0.41 1.69e-14 Sudden cardiac arrest; CRC cis rs9325144 0.723 rs3887436 chr12:39189526 A/C cg26384229 chr12:38710491 ALG10B -0.44 -5.83 -0.31 1.33e-8 Morning vs. evening chronotype; CRC cis rs10504229 0.683 rs55881798 chr8:58106406 T/C cg24829409 chr8:58192753 C8orf71 -0.57 -8.14 -0.41 8.48e-15 Developmental language disorder (linguistic errors); CRC cis rs4713118 0.586 rs6905516 chr6:28086478 A/G cg12963246 chr6:28129442 ZNF389 0.5 5.8 0.3 1.53e-8 Parkinson's disease; CRC cis rs10170846 0.893 rs11692810 chr2:223544096 A/C cg25565276 chr2:223520875 FARSB -0.53 -7.4 -0.38 1.15e-12 Schizophrenia (inflammation and infection response interaction); CRC cis rs1707322 0.650 rs4553239 chr1:46150486 C/A cg06784218 chr1:46089804 CCDC17 0.66 12.41 0.56 2.91e-29 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs2072510 0.643 rs2367755 chr12:96393082 T/C cg22491680 chr12:96389547 HAL -0.49 -7.08 -0.36 8.97e-12 Metabolite levels (small molecules and protein measures); CRC cis rs10504229 0.683 rs11775568 chr8:58133762 G/A cg24829409 chr8:58192753 C8orf71 -0.62 -7.92 -0.4 3.68e-14 Developmental language disorder (linguistic errors); CRC cis rs1552244 0.882 rs9312044 chr3:10037481 T/C cg10729496 chr3:10149963 C3orf24 0.45 6.13 0.32 2.57e-9 Alzheimer's disease; CRC cis rs653465 0.709 rs1609978 chr3:27203626 G/A cg02860705 chr3:27208620 NA -0.39 -6.04 -0.32 4.15e-9 Breast cancer (early onset); CRC cis rs2235649 0.833 rs9922139 chr16:1848329 G/T cg00935504 chr16:1863053 HAGH 0.31 5.65 0.3 3.39e-8 Blood metabolite levels; CRC cis rs2239547 0.618 rs1573815 chr3:52870132 A/G cg10802521 chr3:52805072 NEK4 0.44 5.89 0.31 9.4e-9 Schizophrenia; CRC cis rs1552244 0.572 rs59074548 chr3:10164347 G/C cg08888203 chr3:10149979 C3orf24 0.71 8.57 0.43 4.18e-16 Alzheimer's disease; CRC cis rs6952808 0.760 rs34961072 chr7:1948620 G/C cg20295408 chr7:1910781 MAD1L1 -0.43 -5.86 -0.31 1.11e-8 Bipolar disorder and schizophrenia; CRC cis rs9660180 0.967 rs6664664 chr1:1751264 G/A cg05132306 chr1:1846340 CALML6 -0.46 -7.18 -0.37 4.58e-12 Body mass index; CRC cis rs7772486 0.790 rs2253307 chr6:146196181 T/G cg13319975 chr6:146136371 FBXO30 -0.46 -6.95 -0.36 2.01e-11 Lobe attachment (rater-scored or self-reported); CRC cis rs736408 0.609 rs2230534 chr3:52802402 A/C cg05573699 chr3:52720067 GNL3;PBRM1 -0.46 -6.41 -0.33 5.15e-10 Bipolar disorder; CRC trans rs7615952 0.800 rs11915699 chr3:125632684 A/G cg00769240 chr8:12517080 NA -0.57 -6.69 -0.35 9.86e-11 Blood pressure (smoking interaction); CRC cis rs9814567 0.731 rs34797591 chr3:134192516 A/T cg06109529 chr3:134205091 CEP63;ANAPC13 0.71 8.64 0.43 2.45e-16 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs2839186 0.771 rs2280957 chr21:47642272 A/G cg13126279 chr21:47581558 C21orf56 0.5 8.1 0.41 1.11e-14 Testicular germ cell tumor; CRC cis rs9911578 1.000 rs2055779 chr17:57030561 A/G cg12560992 chr17:57184187 TRIM37 0.93 17.28 0.69 4.48e-48 Intelligence (multi-trait analysis); CRC cis rs546131 0.928 rs553789 chr11:34827579 G/A cg24088639 chr11:34937564 PDHX;APIP -0.48 -6.65 -0.34 1.22e-10 Lung disease severity in cystic fibrosis; CRC cis rs7216064 1.000 rs62084210 chr17:65828710 A/G cg12091567 chr17:66097778 LOC651250 -0.71 -7.76 -0.39 1.06e-13 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg06700265 chr12:12715028 DUSP16 0.42 5.98 0.31 5.88e-9 Response to antipsychotic treatment; CRC cis rs921968 0.510 rs591573 chr2:219478193 C/T cg02176678 chr2:219576539 TTLL4 0.54 8.73 0.43 1.3e-16 Mean corpuscular hemoglobin concentration; CRC cis rs172166 0.769 rs149965 chr6:28018689 T/A cg15786705 chr6:28176104 NA 0.58 8.21 0.41 5.23e-15 Cardiac Troponin-T levels; CRC cis rs7044106 0.762 rs13291660 chr9:123392748 T/C cg09586646 chr9:123605570 PSMD5;LOC253039 0.64 9.57 0.47 2.57e-19 Hip circumference adjusted for BMI; CRC cis rs4843747 0.749 rs72818535 chr16:88074039 G/A cg17633681 chr16:88106987 BANP 0.8 13.72 0.6 3.32e-34 Menopause (age at onset); CRC cis rs6424115 0.931 rs2473377 chr1:24148260 T/C cg10978503 chr1:24200527 CNR2 0.51 9.04 0.45 1.39e-17 Immature fraction of reticulocytes; CRC cis rs9527 0.590 rs1807298 chr10:104870218 G/A cg15744005 chr10:104629667 AS3MT -0.31 -6.12 -0.32 2.69e-9 Arsenic metabolism; CRC cis rs9522267 0.535 rs9515451 chr13:112234382 A/G cg26182253 chr13:112236782 NA 0.31 6.3 0.33 9.74e-10 Hepatitis; CRC cis rs7259376 0.905 rs11879791 chr19:22536939 A/G cg02657401 chr19:22469223 NA -0.33 -7.44 -0.38 8.57e-13 Menopause (age at onset); CRC cis rs62064224 0.512 rs9912766 chr17:30712780 A/G cg12855166 chr17:30846586 MYO1D -0.35 -5.67 -0.3 3.14e-8 Schizophrenia; CRC cis rs7666738 0.830 rs28769113 chr4:98950371 T/G cg05340658 chr4:99064831 C4orf37 0.61 9.54 0.47 3.45e-19 Colonoscopy-negative controls vs population controls; CRC trans rs853679 0.882 rs9393908 chr6:28190830 T/A cg06606381 chr12:133084897 FBRSL1 -1.04 -8.72 -0.43 1.41e-16 Depression; CRC cis rs2075371 0.933 rs2244548 chr7:133986234 A/G cg20476274 chr7:133979776 SLC35B4 0.82 15.11 0.64 1.57e-39 Mean platelet volume; CRC cis rs12477438 1.000 rs12466388 chr2:99916538 T/G cg26064155 chr2:99771622 LIPT1;TSGA10 -0.76 -9.5 -0.46 4.43e-19 Chronic sinus infection; CRC cis rs2932538 0.961 rs2932529 chr1:113193364 G/A cg22162597 chr1:113214053 CAPZA1 -0.69 -9.63 -0.47 1.72e-19 Systolic blood pressure;Diastolic blood pressure;Hypertension;Blood pressure; CRC cis rs995000 0.931 rs636497 chr1:62920029 A/G cg19896129 chr1:63156450 NA 0.44 6.78 0.35 5.59e-11 Triglyceride levels; CRC cis rs7772486 0.754 rs6932863 chr6:146021255 A/T cg05347473 chr6:146136440 FBXO30 -0.39 -5.91 -0.31 8.62e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs1552244 1.000 rs66838678 chr3:10150350 G/A cg02579736 chr3:10068473 FANCD2;CIDECP 1.04 13.81 0.61 1.49e-34 Alzheimer's disease; CRC cis rs9292777 0.720 rs1545334 chr5:40430118 C/T cg09067459 chr5:40385259 NA -0.49 -8.06 -0.41 1.47e-14 Crohn's disease;Multiple sclerosis; CRC cis rs870825 0.616 rs72703531 chr4:185611092 C/T cg07424746 chr4:185654737 MLF1IP -0.57 -5.7 -0.3 2.66e-8 Blood protein levels; CRC cis rs2404602 1.000 rs12148786 chr15:76800362 A/G cg23625390 chr15:77176239 SCAPER 0.62 9.61 0.47 1.92e-19 Blood metabolite levels; CRC cis rs896854 0.653 rs13266313 chr8:95975302 C/T cg13393036 chr8:95962371 TP53INP1 -0.54 -9.29 -0.46 2.16e-18 Type 2 diabetes; CRC cis rs780096 0.587 rs1049817 chr2:27550967 A/G cg02592271 chr2:27665507 KRTCAP3 -0.25 -5.76 -0.3 1.94e-8 Total body bone mineral density; CRC cis rs6860806 0.507 rs272882 chr5:131669161 G/T cg09877947 chr5:131593287 PDLIM4 0.43 7.14 0.37 5.93e-12 Breast cancer; CRC cis rs4481887 1.000 rs7527822 chr1:248467301 A/G cg00666640 chr1:248458726 OR2T12 0.53 9.07 0.45 1.14e-17 Common traits (Other); CRC cis rs7829975 0.535 rs17683510 chr8:8500724 A/G cg06636001 chr8:8085503 FLJ10661 0.47 7.23 0.37 3.49e-12 Mood instability; CRC cis rs11785400 1.000 rs11785400 chr8:143730456 C/T cg24634471 chr8:143751801 JRK 0.53 7.55 0.38 4.26e-13 Schizophrenia; CRC cis rs10504229 1.000 rs17217047 chr8:58180296 G/A cg01721255 chr8:58191610 C8orf71 0.49 6.17 0.32 2e-9 Developmental language disorder (linguistic errors); CRC cis rs919433 0.783 rs2565165 chr2:198233575 T/G cg03934865 chr2:198174659 NA 0.36 5.82 0.31 1.42e-8 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC cis rs2153535 0.541 rs6932434 chr6:8467679 G/A cg07606381 chr6:8435919 SLC35B3 0.67 10.7 0.51 4.01e-23 Motion sickness; CRC cis rs6502050 0.805 rs4789740 chr17:80119202 T/C cg22110888 chr17:80059540 CCDC57 0.41 6.47 0.34 3.51e-10 Life satisfaction; CRC cis rs7923609 0.967 rs10761729 chr10:64995604 G/C cg08743896 chr10:65200160 JMJD1C -0.39 -5.62 -0.3 4.15e-8 Educational attainment;Liver enzyme levels (alkaline phosphatase); CRC trans rs7267979 0.966 rs6083855 chr20:25405118 A/G cg17903999 chr18:56338584 MALT1 0.42 7.06 0.36 9.77e-12 Liver enzyme levels (alkaline phosphatase); CRC cis rs10782582 0.617 rs1846233 chr1:76159354 C/T cg03433033 chr1:76189801 ACADM -0.43 -6.21 -0.32 1.61e-9 Daytime sleep phenotypes; CRC cis rs6502050 0.731 rs11867299 chr17:80088675 C/A cg22110888 chr17:80059540 CCDC57 0.4 6.34 0.33 7.4e-10 Life satisfaction; CRC trans rs28411352 0.922 rs12118489 chr1:38247673 T/G cg19525872 chr12:130934808 RIMBP2 -0.4 -6.01 -0.31 5.04e-9 Rheumatoid arthritis; CRC trans rs1005277 0.505 rs200910 chr10:38108176 C/T cg23533926 chr12:111358616 MYL2 -0.45 -6.66 -0.34 1.15e-10 Extrinsic epigenetic age acceleration; CRC cis rs12906542 0.507 rs4395040 chr15:78282533 G/A cg23683012 chr15:78369302 TBC1D2B 0.49 6.28 0.33 1.07e-9 Breast cancer; CRC cis rs6952808 0.609 rs10230383 chr7:1950113 T/C cg21782813 chr7:2030301 MAD1L1 0.4 7.39 0.38 1.23e-12 Bipolar disorder and schizophrenia; CRC cis rs9403521 1.000 rs6901659 chr6:143985106 T/C cg18240653 chr6:144019428 PHACTR2 -0.56 -6.15 -0.32 2.23e-9 Obesity-related traits; CRC cis rs1401999 0.807 rs9869029 chr3:183735286 C/G cg05044414 chr3:183734942 ABCC5 0.47 8.2 0.41 5.57e-15 Anterior chamber depth; CRC cis rs12745968 0.589 rs6682801 chr1:93074541 C/T cg17283838 chr1:93427260 FAM69A -0.49 -6.6 -0.34 1.62e-10 Bipolar disorder and schizophrenia; CRC cis rs9925964 0.933 rs8050894 chr16:31104509 C/G cg02466173 chr16:30829666 NA 0.4 5.61 0.3 4.4e-8 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs9858542 0.953 rs9837027 chr3:49597013 C/T cg07274523 chr3:49395745 GPX1 0.48 6.45 0.33 4.06e-10 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs1348850 0.914 rs4893961 chr2:178411075 A/G cg02961200 chr2:178257176 LOC100130691;AGPS 0.55 8.06 0.41 1.45e-14 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs3751196 0.708 rs7485127 chr12:104207864 C/T cg02344784 chr12:104178138 NT5DC3 0.7 7.12 0.37 6.87e-12 Sense of smell; CRC cis rs4803455 0.565 rs2241713 chr19:41869468 C/G cg08477640 chr19:41863820 B9D2 -0.43 -6.77 -0.35 5.94e-11 Migraine;Coronary artery disease; CRC cis rs727563 0.635 rs5758444 chr22:42133921 T/A cg06634786 chr22:41940651 POLR3H 0.63 7.25 0.37 2.94e-12 Crohn's disease;Inflammatory bowel disease; CRC cis rs514406 0.667 rs10788942 chr1:53210521 A/T cg27535305 chr1:53392650 SCP2 0.33 6.15 0.32 2.25e-9 Monocyte count; CRC cis rs9486715 0.758 rs2971610 chr6:97027380 C/T cg06623918 chr6:96969491 KIAA0776 -1.03 -20.89 -0.76 2.86e-62 Headache; CRC cis rs12983728 0.572 rs59114323 chr19:58649994 C/T cg08687515 chr19:58661962 ZNF329 0.51 6.32 0.33 8.56e-10 Cholesterol, total; CRC trans rs12495832 0.778 rs6793965 chr3:147938200 A/C cg10221266 chr7:153579447 NA 0.54 6.14 0.32 2.41e-9 Chin dimples; CRC cis rs300703 0.592 rs300800 chr2:105493 T/C cg21211680 chr2:198530 NA -1.05 -11.97 -0.55 1.18e-27 Blood protein levels; CRC cis rs4243830 0.850 rs4434862 chr1:6602241 C/A cg05709478 chr1:6581295 PLEKHG5 -0.56 -6.68 -0.35 1.05e-10 Body mass index; CRC cis rs912057 0.609 rs1294431 chr6:6745003 G/C cg06612196 chr6:6737390 NA 0.54 8.62 0.43 2.84e-16 Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction); CRC cis rs853679 0.517 rs9393885 chr6:28050009 A/T cg21251018 chr6:28226885 NKAPL 0.47 6.23 0.33 1.39e-9 Depression; CRC cis rs13191362 1.000 rs73008453 chr6:163013384 G/A cg23758597 chr6:163146217 PARK2 -0.55 -6.12 -0.32 2.7e-9 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs9916302 0.847 rs7218670 chr17:37500424 G/A cg03013999 chr17:37608204 MED1 -0.48 -7.42 -0.38 9.94e-13 Glomerular filtration rate (creatinine); CRC cis rs501916 1.000 rs3743276 chr15:48055119 C/T cg16110827 chr15:48056943 SEMA6D 0.35 6.0 0.31 5.06e-9 Inflammatory bowel disease;Ulcerative colitis; CRC cis rs7394190 0.748 rs3088070 chr10:75530013 C/T cg07699608 chr10:75541558 CHCHD1 0.61 6.37 0.33 6.53e-10 Incident atrial fibrillation; CRC cis rs9902453 0.845 rs3115099 chr17:28019293 T/C cg26525008 chr17:28256777 EFCAB5;SSH2 0.6 8.98 0.44 2.17e-17 Coffee consumption (cups per day); CRC cis rs2836974 0.590 rs9974757 chr21:40617244 T/C cg11890956 chr21:40555474 PSMG1 -0.91 -15.96 -0.66 7.54e-43 Cognitive function; CRC cis rs3749237 0.595 rs11130196 chr3:49490149 A/C cg03060546 chr3:49711283 APEH 0.61 10.33 0.49 7.72e-22 Resting heart rate; CRC cis rs11148252 1.000 rs4886018 chr13:52990717 C/T cg00495681 chr13:53174319 NA 0.55 8.47 0.42 8.11e-16 Lewy body disease; CRC cis rs2030114 0.583 rs7195329 chr16:51590733 G/A cg03758633 chr16:51611768 NA 0.35 5.84 0.31 1.28e-8 Blood pressure measurement (high sodium and potassium intervention); CRC cis rs9291683 0.609 rs55959894 chr4:10026580 G/A cg11266682 chr4:10021025 SLC2A9 0.54 11.35 0.53 2.02e-25 Bone mineral density; CRC trans rs7267979 0.933 rs2258728 chr20:25276343 G/A cg17903999 chr18:56338584 MALT1 -0.41 -6.79 -0.35 5.11e-11 Liver enzyme levels (alkaline phosphatase); CRC cis rs2576037 0.583 rs12386118 chr18:44540376 C/G cg07643061 chr18:44555308 TCEB3C;TCEB3CL;KATNAL2 -0.34 -5.74 -0.3 2.12e-8 Personality dimensions; CRC trans rs13079221 0.614 rs172429 chr3:14905513 T/G cg18308285 chr17:7942551 ALOX15B 0.42 6.12 0.32 2.66e-9 Coronary artery disease; CRC cis rs1799949 1.000 rs8176083 chr17:41275151 G/C cg19454999 chr17:41278357 BRCA1;NBR2 0.54 8.26 0.41 3.56e-15 Menopause (age at onset); CRC cis rs12431939 0.857 rs4547259 chr14:51669224 T/G cg23942311 chr14:51606299 NA 0.49 6.73 0.35 7.53e-11 Cancer; CRC cis rs67311347 0.955 rs2085114 chr3:40497437 T/A cg09455208 chr3:40491958 NA 0.48 9.32 0.46 1.75e-18 Renal cell carcinoma; CRC cis rs739401 0.595 rs6578305 chr11:3001120 C/T cg05729581 chr11:3078854 CARS -0.51 -7.51 -0.38 5.8e-13 Longevity; CRC cis rs12824058 0.767 rs4759654 chr12:130815559 A/G cg24838063 chr12:130822603 PIWIL1 0.58 9.82 0.48 3.93e-20 Menopause (age at onset); CRC cis rs4285028 0.699 rs1920297 chr3:121598000 T/C cg20356878 chr3:121714668 ILDR1 -0.48 -6.67 -0.35 1.1e-10 Multiple sclerosis; CRC trans rs2303319 0.504 rs56026147 chr2:162614089 T/C cg10498984 chr16:28874827 SH2B1 -0.73 -6.3 -0.33 9.75e-10 Cognitive function; CRC cis rs7799006 0.606 rs12669625 chr7:2315950 C/T cg08027265 chr7:2291960 NA -0.46 -7.88 -0.4 4.7e-14 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs12497850 0.931 rs4974079 chr3:48906469 T/G cg07636037 chr3:49044803 WDR6 1.03 18.15 0.71 1.69e-51 Parkinson's disease; CRC cis rs9292777 0.933 rs6879489 chr5:40425190 T/G cg09067459 chr5:40385259 NA 0.53 9.25 0.45 3.02e-18 Crohn's disease;Multiple sclerosis; CRC cis rs9322193 0.923 rs4869750 chr6:150177132 C/T cg13206674 chr6:150067644 NUP43 0.56 8.16 0.41 7.26e-15 Lung cancer; CRC cis rs2066819 0.786 rs116934693 chr12:56696545 T/G cg26714650 chr12:56694279 CS -1.38 -11.53 -0.54 4.7e-26 Psoriasis vulgaris; CRC cis rs4660306 1.000 rs1044717 chr1:45976587 A/G cg03123370 chr1:45965343 CCDC163P;MMACHC -0.56 -7.96 -0.4 2.9e-14 Homocysteine levels; CRC cis rs6964587 1.000 rs6951972 chr7:91689446 T/G cg17063962 chr7:91808500 NA 0.8 14.02 0.61 2.36e-35 Breast cancer; CRC cis rs2239547 0.563 rs4687699 chr3:53101224 C/T cg15147215 chr3:52552868 STAB1 -0.44 -6.48 -0.34 3.28e-10 Schizophrenia; CRC cis rs4803468 1.000 rs8105833 chr19:41896145 G/A cg09537434 chr19:41945824 ATP5SL -0.92 -18.3 -0.71 4.41e-52 Height; CRC cis rs6424115 1.000 rs34477640 chr1:24154067 T/C cg09473613 chr1:24152604 HMGCL -0.36 -6.16 -0.32 2.1e-9 Immature fraction of reticulocytes; CRC cis rs4363385 0.720 rs1415968 chr1:152970219 C/G cg25856811 chr1:152973957 SPRR3 -0.25 -6.92 -0.36 2.36e-11 Inflammatory skin disease; CRC cis rs11212617 1.000 rs11212617 chr11:108283161 G/T cg14761454 chr11:108092087 ATM;NPAT 0.43 6.3 0.33 9.79e-10 Response to metformin in type 2 diabetes (glycemic); CRC cis rs9309473 1.000 rs6736866 chr2:73661986 C/G cg20560298 chr2:73613845 ALMS1 -0.51 -5.99 -0.31 5.54e-9 Metabolite levels; CRC cis rs875971 0.964 rs6978721 chr7:65883204 A/G cg12463550 chr7:65579703 CRCP 0.48 6.96 0.36 1.89e-11 Aortic root size; CRC cis rs6674176 0.597 rs12127737 chr1:44402565 G/A cg13606994 chr1:44402422 ARTN -0.39 -6.57 -0.34 1.94e-10 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Cognitive ability; CRC cis rs2014572 0.967 rs4801452 chr19:57768066 A/G cg12963866 chr19:57752005 ZNF805 -0.43 -6.32 -0.33 8.31e-10 Hyperactive-impulsive symptoms; CRC cis rs17767294 0.612 rs9461425 chr6:27919688 G/A cg03623178 chr6:28175578 NA 0.72 7.24 0.37 3.29e-12 Parkinson's disease; CRC cis rs6500395 0.926 rs7192297 chr16:48670421 G/A cg04672837 chr16:48644449 N4BP1 0.45 6.73 0.35 7.64e-11 Response to tocilizumab in rheumatoid arthritis; CRC cis rs11628318 0.614 rs7155489 chr14:103123119 C/T cg08075719 chr14:103021372 NA 0.6 6.65 0.34 1.19e-10 Platelet count; CRC cis rs853679 0.760 rs9368563 chr6:28208558 A/G cg21251018 chr6:28226885 NKAPL 0.51 5.95 0.31 6.9e-9 Depression; CRC cis rs243505 0.528 rs1558419 chr7:148480233 C/T cg09806900 chr7:148480153 CUL1 0.56 8.45 0.42 9.87e-16 Inflammatory bowel disease;Crohn's disease; CRC cis rs11971779 0.680 rs6954531 chr7:139054706 C/T cg07862535 chr7:139043722 LUC7L2 0.57 7.35 0.38 1.61e-12 Diisocyanate-induced asthma; CRC cis rs2243480 0.803 rs55700941 chr7:65389800 T/A cg18252515 chr7:66147081 NA -1.09 -12.53 -0.57 1.06e-29 Diabetic kidney disease; CRC cis rs9467773 0.595 rs2237236 chr6:26451553 A/G cg09904177 chr6:26538194 HMGN4 -0.44 -6.18 -0.32 1.87e-9 Intelligence (multi-trait analysis); CRC cis rs6540556 0.834 rs6700223 chr1:209935031 G/A cg23920097 chr1:209922102 NA -0.5 -6.39 -0.33 5.6e-10 Red blood cell count; CRC cis rs7618915 0.547 rs62253700 chr3:52625019 T/A cg18099408 chr3:52552593 STAB1 -0.44 -7.31 -0.37 2e-12 Bipolar disorder; CRC cis rs7772486 0.875 rs2814875 chr6:146305810 G/A cg23711669 chr6:146136114 FBXO30 0.68 11.55 0.54 3.94e-26 Lobe attachment (rater-scored or self-reported); CRC cis rs6597981 0.592 rs10902218 chr11:743813 C/T cg21775979 chr11:780331 NA 0.4 6.46 0.34 3.72e-10 Breast cancer; CRC cis rs6964587 1.000 rs36120033 chr7:91679298 G/A cg17063962 chr7:91808500 NA 0.8 14.21 0.62 4.48e-36 Breast cancer; CRC cis rs875971 0.825 rs1860472 chr7:66082723 T/C cg11764359 chr7:65958608 NA -0.59 -8.76 -0.43 1.09e-16 Aortic root size; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg21156815 chr8:22526736 BIN3 0.4 6.79 0.35 5.33e-11 Liver disease severity in Alagille syndrome; CRC cis rs477895 1.000 rs34292685 chr11:64049021 C/T cg18375707 chr11:64034959 PLCB3 0.48 5.96 0.31 6.38e-9 Mean platelet volume; CRC cis rs2070488 0.965 rs7433277 chr3:38529818 C/T cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.93 17.32 0.69 3.19e-48 Electrocardiographic conduction measures; CRC cis rs6952808 0.723 rs4721295 chr7:2036669 G/T cg21782813 chr7:2030301 MAD1L1 -0.53 -9.46 -0.46 5.88e-19 Bipolar disorder and schizophrenia; CRC cis rs9303280 0.868 rs11650661 chr17:38026286 A/T cg20243544 chr17:37824526 PNMT 0.42 6.6 0.34 1.69e-10 Self-reported allergy; CRC cis rs4555082 0.834 rs2816651 chr14:105708470 A/G cg13114125 chr14:105738426 BRF1 -0.76 -11.42 -0.53 1.15e-25 Mean platelet volume;Platelet distribution width; CRC cis rs7626444 0.625 rs9877495 chr3:196483280 G/A cg12930392 chr3:196481615 PAK2 0.39 7.11 0.36 7.25e-12 Monocyte count; CRC cis rs10751667 0.666 rs6597967 chr11:950583 G/T cg01483505 chr11:975446 AP2A2 0.42 6.83 0.35 4.14e-11 Alzheimer's disease (late onset); CRC cis rs9487051 0.837 rs4403290 chr6:109611583 A/T cg21918786 chr6:109611834 NA -0.44 -8.12 -0.41 9.71e-15 Reticulocyte fraction of red cells; CRC cis rs736408 0.648 rs3774354 chr3:52817675 G/A cg11645453 chr3:52864694 ITIH4 0.39 6.64 0.34 1.26e-10 Bipolar disorder; CRC cis rs7618501 0.633 rs6772095 chr3:49978069 C/T cg05623727 chr3:50126028 RBM5 0.46 7.58 0.39 3.49e-13 Intelligence (multi-trait analysis); CRC cis rs3806843 0.766 rs6848 chr5:140086062 A/T cg19875535 chr5:140030758 IK -0.53 -8.71 -0.43 1.51e-16 Depressive symptoms (multi-trait analysis); CRC cis rs853679 0.517 rs4711165 chr6:28115184 T/G cg02683197 chr6:28174875 NA 0.87 10.73 0.51 3.25e-23 Depression; CRC cis rs28386778 0.897 rs4968599 chr17:61835992 T/C cg06601766 chr17:61851465 DDX42;CCDC47 0.45 6.1 0.32 3.06e-9 Prudent dietary pattern; CRC cis rs7618501 0.633 rs9861216 chr3:50059339 A/G cg05623727 chr3:50126028 RBM5 -0.43 -7.31 -0.37 2.04e-12 Intelligence (multi-trait analysis); CRC cis rs10131894 0.611 rs175002 chr14:75436466 C/G cg03030879 chr14:75389066 RPS6KL1 -0.4 -6.36 -0.33 6.75e-10 Coronary artery disease; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg00429477 chr12:6798907 ZNF384 0.45 7.0 0.36 1.4e-11 Liver disease severity in Alagille syndrome; CRC cis rs611744 0.669 rs13251024 chr8:109258333 T/C cg21045802 chr8:109455806 TTC35 0.42 6.68 0.35 1.05e-10 Dupuytren's disease; CRC cis rs10504229 0.600 rs6987243 chr8:58115406 T/C cg24829409 chr8:58192753 C8orf71 -0.55 -8.03 -0.4 1.71e-14 Developmental language disorder (linguistic errors); CRC cis rs9435341 1.000 rs9435341 chr1:107616641 T/C cg11070056 chr1:107600091 PRMT6 -0.37 -5.61 -0.3 4.31e-8 Facial morphology (factor 21, depth of nasal alae); CRC cis rs6952808 0.573 rs12668848 chr7:2020995 G/A cg22963979 chr7:1858916 MAD1L1 -0.46 -7.04 -0.36 1.11e-11 Bipolar disorder and schizophrenia; CRC cis rs1218582 0.772 rs6669791 chr1:154845484 G/T cg16680214 chr1:154839983 KCNN3 -0.48 -9.57 -0.47 2.72e-19 Prostate cancer; CRC cis rs4658101 0.906 rs1192404 chr1:92068967 A/G cg24006770 chr1:92056542 NA 0.5 5.77 0.3 1.87e-8 Optic disc area;Vertical cup-disc ratio; CRC cis rs7089973 0.564 rs55671354 chr10:116571281 T/C cg23260525 chr10:116636907 FAM160B1 0.39 8.87 0.44 4.87e-17 Bipolar disorder or attention deficit hyperactivity disorder; CRC cis rs736408 0.509 rs13083798 chr3:52649748 A/G cg08222913 chr3:52553049 STAB1 -0.36 -7.11 -0.37 7.12e-12 Bipolar disorder; CRC cis rs7264396 0.563 rs6060558 chr20:34271092 C/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.43 -5.71 -0.3 2.52e-8 Total cholesterol levels; CRC cis rs10504229 0.683 rs6999984 chr8:58115079 G/A cg21724239 chr8:58056113 NA 0.49 6.79 0.35 5.28e-11 Developmental language disorder (linguistic errors); CRC cis rs6743376 0.556 rs2515396 chr2:113819175 G/A cg09040174 chr2:113837401 NA 0.44 6.5 0.34 3.01e-10 Inflammatory biomarkers; CRC cis rs77106637 1.000 rs76793820 chr11:72619860 G/A cg03713592 chr11:72463424 ARAP1 0.76 7.13 0.37 6.24e-12 Type 2 diabetes; CRC trans rs7615952 0.800 rs13086460 chr3:125646417 C/T cg02007433 chr3:129722099 NA -0.46 -6.3 -0.33 9.67e-10 Blood pressure (smoking interaction); CRC cis rs2832191 0.511 rs7278227 chr21:30482707 C/T cg08807101 chr21:30365312 RNF160 -0.5 -6.85 -0.35 3.68e-11 Dental caries; CRC cis rs2243480 1.000 rs34136756 chr7:65381256 A/G cg18252515 chr7:66147081 NA -1.1 -12.86 -0.58 6.13e-31 Diabetic kidney disease; CRC cis rs875971 0.862 rs2420174 chr7:65645361 C/T cg00343986 chr7:65444356 GUSB -0.42 -5.97 -0.31 6.07e-9 Aortic root size; CRC cis rs2842992 0.789 rs6908680 chr6:160218209 G/T cg19482086 chr6:160211437 TCP1;MRPL18 0.74 9.54 0.47 3.36e-19 Age-related macular degeneration (geographic atrophy); CRC cis rs6951245 1.000 rs79443843 chr7:1075245 G/A cg20603222 chr7:1096387 C7orf50;GPR146 -0.67 -7.88 -0.4 4.97e-14 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs4843747 0.749 rs13333619 chr16:88072076 C/T cg03395651 chr16:88107091 BANP 0.58 7.63 0.39 2.6e-13 Menopause (age at onset); CRC cis rs6964587 1.000 rs9690208 chr7:91735613 T/A cg17063962 chr7:91808500 NA 0.8 13.89 0.61 7.52e-35 Breast cancer; CRC cis rs4819052 0.808 rs2246697 chr21:46689999 G/A cg02159808 chr21:46707872 POFUT2;LOC642852 0.51 6.71 0.35 8.75e-11 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs644799 0.735 rs10831432 chr11:95516040 C/A cg25478527 chr11:95522999 CEP57;FAM76B 0.5 7.72 0.39 1.37e-13 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs9463078 0.677 rs1886345 chr6:45078266 A/G cg25276700 chr6:44698697 NA -0.24 -5.64 -0.3 3.72e-8 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg22979080 chr17:4693765 NA 0.41 6.25 0.33 1.27e-9 Intelligence (multi-trait analysis); CRC cis rs10504229 1.000 rs1961778 chr8:58168756 G/A cg22535103 chr8:58192502 C8orf71 -0.78 -12.13 -0.56 3.17e-28 Developmental language disorder (linguistic errors); CRC cis rs2976388 0.609 rs2585153 chr8:143785345 G/A cg12516270 chr8:143859308 LYNX1 0.44 7.8 0.4 8.3e-14 Urinary tract infection frequency; CRC cis rs4665809 1.000 rs1560868 chr2:26281459 A/T cg22920501 chr2:26401640 FAM59B 0.56 7.76 0.39 1.11e-13 Gut microbiome composition (summer); CRC cis rs6445967 1.000 rs6777105 chr3:58307644 A/G cg23715586 chr3:58305044 RPP14 0.35 5.99 0.31 5.37e-9 Platelet count; CRC cis rs2072510 0.569 rs61937880 chr12:96390867 C/A cg22491680 chr12:96389547 HAL -0.49 -6.08 -0.32 3.33e-9 Metabolite levels (small molecules and protein measures); CRC cis rs4713118 0.955 rs9380010 chr6:27683572 A/G cg02683197 chr6:28174875 NA 0.57 7.53 0.38 5.05e-13 Parkinson's disease; CRC cis rs9469913 0.542 rs114863007 chr6:34729158 G/A cg17674042 chr6:34482479 PACSIN1 -0.89 -7.9 -0.4 4.21e-14 Body mass index (joint analysis main effects and physical activity interaction);Body mass index;Body mass index in physically active individuals; CRC cis rs344364 0.636 rs344363 chr16:1972548 C/T cg03013636 chr16:1946785 NA 0.57 6.56 0.34 2.07e-10 Glomerular filtration rate in chronic kidney disease; CRC cis rs4319547 1.000 rs1392236 chr12:123074890 C/G cg05707623 chr12:122985044 ZCCHC8 -0.75 -9.41 -0.46 9.07e-19 Body mass index; CRC cis rs2976388 0.578 rs13263987 chr8:143827387 A/C cg05569086 chr8:143859399 LYNX1 -0.4 -6.33 -0.33 8.02e-10 Urinary tract infection frequency; CRC cis rs863345 0.604 rs12034004 chr1:158463885 A/G cg12129480 chr1:158549410 OR10X1 -0.3 -6.32 -0.33 8.42e-10 Pneumococcal bacteremia; CRC cis rs875971 0.545 rs73376394 chr7:65637681 C/T cg03233332 chr7:66118400 NA -0.41 -5.97 -0.31 6.29e-9 Aortic root size; CRC cis rs11148252 0.557 rs9536223 chr13:53233194 A/T cg12458913 chr13:53173898 NA 0.77 14.02 0.61 2.45e-35 Lewy body disease; CRC cis rs3096299 0.933 rs2965934 chr16:89481229 C/G cg01788221 chr16:89496183 ANKRD11 -0.48 -7.45 -0.38 8.5e-13 Multiple myeloma (IgH translocation); CRC cis rs2625529 0.730 rs6494975 chr15:72177825 T/A cg16672083 chr15:72433130 SENP8 0.49 7.44 0.38 8.81e-13 Red blood cell count; CRC cis rs17092148 0.887 rs4911430 chr20:33145404 C/G cg08999081 chr20:33150536 PIGU 0.51 6.6 0.34 1.66e-10 Neuroticism; CRC cis rs2857891 0.695 rs2346002 chr11:6987741 T/C cg04053776 chr11:6947353 ZNF215 0.42 6.38 0.33 6.16e-10 Response to cytadine analogues (cytosine arabinoside); CRC cis rs8063761 1.000 rs8063761 chr16:90027626 A/T cg25193494 chr16:90016004 DEF8 0.52 7.45 0.38 8.56e-13 Squamous cell carcinoma; CRC cis rs4780401 0.609 rs4781143 chr16:11809721 T/G cg01061890 chr16:11836724 TXNDC11 -0.62 -9.13 -0.45 7.34e-18 Rheumatoid arthritis; CRC cis rs17767294 0.612 rs9461425 chr6:27919688 G/A cg02683197 chr6:28174875 NA 0.74 7.45 0.38 8.36e-13 Parkinson's disease; CRC cis rs6011002 0.808 rs1291211 chr20:62337622 A/G cg01176363 chr20:62369445 LIME1 -0.6 -5.71 -0.3 2.49e-8 Dental caries; CRC cis rs4938330 0.608 rs4938358 chr11:117084091 C/T cg01368799 chr11:117014884 PAFAH1B2 -0.47 -6.0 -0.31 5.31e-9 Blood protein levels; CRC cis rs11622475 1.000 rs34964872 chr14:104448435 T/A cg12183467 chr14:104352244 NA -0.48 -6.71 -0.35 8.32e-11 Bipolar disorder; CRC cis rs11098499 0.955 rs35197422 chr4:120169314 T/G cg09307838 chr4:120376055 NA 0.61 9.47 0.46 5.44e-19 Corneal astigmatism; CRC cis rs7274811 0.681 rs158676 chr20:31974395 G/A cg07470512 chr20:32255052 NECAB3;C20orf134 0.43 5.92 0.31 8.01e-9 Height; CRC cis rs12580194 0.593 rs79104523 chr12:55749220 T/C cg19537932 chr12:55886519 OR6C68 -0.69 -8.95 -0.44 2.63e-17 Cancer; CRC cis rs12612619 0.704 rs6742004 chr2:27309659 A/C cg00617064 chr2:27272375 NA -0.37 -6.03 -0.32 4.51e-9 Venous thromboembolism adjusted for sickle cell variant rs77121243-T; CRC cis rs2898681 0.519 rs76606067 chr4:53728221 G/T cg00338735 chr4:53728038 RASL11B 0.48 6.51 0.34 2.8e-10 Optic nerve measurement (cup area); CRC cis rs10256972 0.577 rs2949179 chr7:1209885 C/G cg09177884 chr7:1199841 ZFAND2A -0.56 -8.52 -0.43 5.72e-16 Longevity;Endometriosis; CRC trans rs35110281 0.693 rs11089093 chr21:45121161 C/T cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.44 7.08 0.36 8.66e-12 Mean corpuscular volume; CRC cis rs10504229 0.683 rs56192850 chr8:58135356 A/G cg02290350 chr8:58132656 NA -0.58 -8.16 -0.41 7.29e-15 Developmental language disorder (linguistic errors); CRC cis rs4474465 1.000 rs10899505 chr11:78165343 T/C cg27205649 chr11:78285834 NARS2 -0.45 -5.7 -0.3 2.63e-8 Alzheimer's disease (survival time); CRC cis rs12824058 0.831 rs4759655 chr12:130815740 A/G cg24838063 chr12:130822603 PIWIL1 -0.59 -9.91 -0.48 2.02e-20 Menopause (age at onset); CRC cis rs1005277 0.540 rs2224248 chr10:38451886 A/G cg25427524 chr10:38739819 LOC399744 -0.76 -13.4 -0.59 5.88e-33 Extrinsic epigenetic age acceleration; CRC trans rs9747201 0.926 rs35131420 chr17:80103631 T/C cg07393940 chr7:158741817 NA -0.51 -7.38 -0.38 1.27e-12 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs10504229 0.639 rs2318145 chr8:58114867 A/G cg21724239 chr8:58056113 NA 0.49 6.77 0.35 5.94e-11 Developmental language disorder (linguistic errors); CRC trans rs9747201 1.000 rs36048409 chr17:80096961 T/A cg07393940 chr7:158741817 NA -0.52 -7.44 -0.38 8.79e-13 Peripheral arterial disease (traffic-related air pollution interaction); CRC trans rs7267979 1.000 rs6050599 chr20:25400240 T/C cg17903999 chr18:56338584 MALT1 0.41 6.92 0.36 2.4e-11 Liver enzyme levels (alkaline phosphatase); CRC cis rs2625529 0.689 rs4526973 chr15:72138719 A/G cg16672083 chr15:72433130 SENP8 -0.44 -6.68 -0.35 9.99e-11 Red blood cell count; CRC cis rs2153535 0.601 rs1928183 chr6:8530018 A/G cg07606381 chr6:8435919 SLC35B3 0.67 10.98 0.52 4.03e-24 Motion sickness; CRC cis rs1129187 0.720 rs9471972 chr6:42915021 G/A cg02353165 chr6:42928485 GNMT 0.65 10.45 0.5 2.82e-22 Alzheimer's disease in APOE e4+ carriers; CRC cis rs4604732 0.631 rs11490198 chr1:247625703 A/G cg02104434 chr1:247694406 LOC148824;OR2C3 0.6 8.82 0.44 6.67e-17 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CRC cis rs1348850 0.958 rs4243390 chr2:178468008 G/A cg22681709 chr2:178499509 PDE11A -0.34 -6.25 -0.33 1.27e-9 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs7811142 0.830 rs10085549 chr7:99983135 C/T cg00814883 chr7:100076585 TSC22D4 -0.68 -8.65 -0.43 2.29e-16 Platelet count; CRC cis rs55788414 0.932 rs11649028 chr16:81185326 G/A cg06400318 chr16:81190750 PKD1L2 0.55 6.75 0.35 6.88e-11 Left ventricular obstructive tract defect (maternal effect); CRC cis rs7940866 0.903 rs10750457 chr11:130850277 T/C cg12179176 chr11:130786555 SNX19 0.55 8.31 0.42 2.49e-15 Schizophrenia; CRC cis rs858239 0.867 rs10250602 chr7:23303701 T/C cg00469287 chr7:23338798 C7orf30 0.46 5.83 0.31 1.3e-8 Cerebrospinal fluid biomarker levels; CRC cis rs9649213 0.593 rs13246725 chr7:97914898 C/G cg00277769 chr7:97922759 BAIAP2L1 -0.61 -10.79 -0.51 1.87e-23 Prostate cancer (SNP x SNP interaction); CRC cis rs6662572 0.737 rs56301932 chr1:46422086 G/A cg08644498 chr1:46502608 NA 0.44 6.87 0.35 3.31e-11 Blood protein levels; CRC cis rs2404602 0.583 rs3759853 chr15:76587777 C/T cg26408565 chr15:76604113 ETFA -0.36 -5.75 -0.3 2.08e-8 Blood metabolite levels; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg13521891 chr12:95466445 NR2C1 0.45 6.02 0.31 4.67e-9 Thyroid stimulating hormone; CRC cis rs9303401 0.704 rs740605 chr17:56604811 C/T cg12560992 chr17:57184187 TRIM37 0.58 8.69 0.43 1.72e-16 Cognitive test performance; CRC cis rs7618501 0.933 rs6809431 chr3:49804119 A/G cg24308560 chr3:49941425 MST1R -0.47 -7.44 -0.38 9e-13 Intelligence (multi-trait analysis); CRC cis rs73195822 0.667 rs60579973 chr12:111245629 C/T cg12870014 chr12:110450643 ANKRD13A 0.65 5.65 0.3 3.54e-8 Itch intensity from mosquito bite; CRC cis rs6860806 0.661 rs2136187 chr5:131577894 T/C cg22638593 chr5:131593259 PDLIM4 0.42 7.87 0.4 5.24e-14 Breast cancer; CRC cis rs6585424 0.925 rs11201964 chr10:81931367 A/G cg11900509 chr10:81946545 ANXA11 -0.72 -8.84 -0.44 5.72e-17 Chronic obstructive pulmonary disease-related biomarkers; CRC trans rs12432203 1.000 rs61987265 chr14:51728808 T/C cg14592830 chr9:122318704 NA 0.6 6.18 0.32 1.92e-9 Cancer; CRC cis rs7107174 0.892 rs2512540 chr11:77979299 A/G cg02023728 chr11:77925099 USP35 0.51 7.42 0.38 1e-12 Testicular germ cell tumor; CRC cis rs367943 0.730 rs2914174 chr5:112978531 C/T cg12552261 chr5:112820674 MCC -0.39 -6.08 -0.32 3.38e-9 Type 2 diabetes; CRC cis rs11167764 0.945 rs891991 chr5:141484977 A/T cg08523384 chr5:141488047 NDFIP1 -0.51 -8.59 -0.43 3.5e-16 Crohn's disease; CRC cis rs11650494 0.516 rs117384420 chr17:47505383 G/C cg08112188 chr17:47440006 ZNF652 0.84 6.89 0.36 2.82e-11 Prostate cancer; CRC cis rs1799949 1.000 rs8176297 chr17:41203325 T/A cg23758822 chr17:41437982 NA 0.8 13.69 0.6 4.46e-34 Menopause (age at onset); CRC trans rs12599106 0.754 rs11640596 chr16:34347277 T/C cg01171360 chr6:293285 DUSP22 -0.47 -6.67 -0.35 1.09e-10 Menopause (age at onset); CRC cis rs7512552 0.780 rs2794681 chr1:150321951 C/T cg15654264 chr1:150340011 RPRD2 0.58 8.1 0.41 1.08e-14 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); CRC cis rs4665809 0.590 rs7260 chr2:26413917 C/T cg27170947 chr2:26402098 FAM59B -0.59 -7.86 -0.4 5.7e-14 Gut microbiome composition (summer); CRC cis rs13191362 0.938 rs13192618 chr6:163132822 T/C cg21926612 chr6:163149169 PACRG;PARK2 0.97 13.1 0.59 7.85e-32 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs11583043 1.000 rs6675353 chr1:101459625 A/T cg16556008 chr1:101360663 SLC30A7;EXTL2 0.46 5.99 0.31 5.41e-9 Ulcerative colitis;Inflammatory bowel disease; CRC trans rs1005277 0.579 rs2474571 chr10:38384639 T/G cg17830980 chr10:43048298 ZNF37B -0.6 -9.94 -0.48 1.53e-20 Extrinsic epigenetic age acceleration; CRC cis rs1003719 0.762 rs2835598 chr21:38466669 T/C cg10648535 chr21:38446584 PIGP;TTC3 0.52 7.41 0.38 1.07e-12 Eye color traits; CRC cis rs9463078 0.804 rs9395086 chr6:45225331 T/A cg25276700 chr6:44698697 NA -0.27 -6.52 -0.34 2.68e-10 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; CRC cis rs1448094 0.967 rs1374995 chr12:86341764 A/G cg18827107 chr12:86230957 RASSF9 -0.39 -6.31 -0.33 8.89e-10 Major depressive disorder; CRC cis rs7246657 0.943 rs10413602 chr19:37891492 T/C cg23950597 chr19:37808831 NA -0.54 -6.52 -0.34 2.58e-10 Coronary artery calcification; CRC cis rs3736485 0.966 rs4774596 chr15:51910975 C/A cg08986416 chr15:51914746 DMXL2 -0.46 -6.38 -0.33 5.97e-10 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs6860806 0.531 rs272887 chr5:131665713 A/G cg20512303 chr5:131592959 PDLIM4 0.39 6.71 0.35 8.63e-11 Breast cancer; CRC cis rs4362 0.902 rs4325 chr17:61563200 G/T cg21881537 chr17:61574411 ACE 0.34 5.87 0.31 1.09e-8 Blood metabolite levels; CRC cis rs6076065 0.723 rs6132604 chr20:23342226 G/A cg11657817 chr20:23433608 CST11 0.44 6.55 0.34 2.26e-10 Facial morphology (factor 15, philtrum width); CRC cis rs8067545 0.611 rs2703777 chr17:20138891 C/T cg13482628 chr17:19912719 NA -0.46 -7.33 -0.37 1.74e-12 Schizophrenia; CRC cis rs1577917 0.958 rs10944136 chr6:86448499 C/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.54 -7.24 -0.37 3.22e-12 Response to antipsychotic treatment; CRC cis rs185694 1.000 rs202101 chr13:30897337 A/G cg04551440 chr13:30881194 KATNAL1 -0.61 -6.22 -0.32 1.48e-9 Antineutrophil cytoplasmic antibody-associated vasculitis; CRC cis rs9309473 1.000 rs13428235 chr2:73633430 G/A cg20560298 chr2:73613845 ALMS1 -0.47 -5.97 -0.31 6.15e-9 Metabolite levels; CRC cis rs1552244 0.554 rs6762594 chr3:9995516 G/A cg02579736 chr3:10068473 FANCD2;CIDECP 0.64 9.07 0.45 1.07e-17 Alzheimer's disease; CRC cis rs3018066 0.698 rs10027207 chr4:107083779 T/C cg01869342 chr4:106983673 TBCK 0.37 5.74 0.3 2.15e-8 Cancer; CRC cis rs1448094 0.556 rs11614513 chr12:86167756 G/C cg02569458 chr12:86230093 RASSF9 0.48 8.02 0.4 1.9e-14 Major depressive disorder; CRC trans rs2727020 0.530 rs7113153 chr11:49457957 G/A cg15704280 chr7:45808275 SEPT13 -0.72 -9.38 -0.46 1.1e-18 Coronary artery disease; CRC cis rs7524258 0.868 rs10779678 chr1:7300573 A/G cg07173049 chr1:7289937 CAMTA1 0.61 9.83 0.48 3.62e-20 Tourette's syndrome or obsessive-compulsive disorder; CRC cis rs752092 1.000 rs8033360 chr15:101778710 C/A cg19997662 chr15:101784653 CHSY1 -0.62 -10.1 -0.49 4.71e-21 Corneal structure; CRC cis rs9916302 0.706 rs7503081 chr17:37482673 A/G cg07936489 chr17:37558343 FBXL20 0.9 11.59 0.54 2.74e-26 Glomerular filtration rate (creatinine); CRC cis rs7613875 0.620 rs7634441 chr3:50071677 G/A cg24308560 chr3:49941425 MST1R 0.43 6.82 0.35 4.25e-11 Body mass index; CRC cis rs6684514 0.961 rs12126696 chr1:156241348 C/T cg16558208 chr1:156270281 VHLL 0.62 9.83 0.48 3.57e-20 Mean corpuscular hemoglobin concentration;Glycated hemoglobin levels; CRC cis rs2019137 0.560 rs10175462 chr2:113988492 G/A cg23564664 chr2:113997917 PAX8;LOC654433;LOC440839 -0.36 -5.96 -0.31 6.38e-9 Lymphocyte counts; CRC cis rs4561483 0.624 rs2215928 chr16:11927918 A/T cg08843971 chr16:11963173 GSPT1 -0.46 -7.14 -0.37 6.1e-12 Testicular germ cell tumor; CRC cis rs1580019 0.563 rs896137 chr7:32579345 G/T cg07520158 chr7:32535189 LSM5;AVL9 0.53 7.76 0.39 1.07e-13 Cognitive ability; CRC cis rs738322 0.805 rs2235344 chr22:38518083 G/A cg25457927 chr22:38595422 NA -0.31 -6.3 -0.33 9.47e-10 Cutaneous nevi; CRC trans rs2303319 0.504 rs57464189 chr2:162419312 G/A cg27113153 chr11:123612418 ZNF202 -0.72 -6.15 -0.32 2.25e-9 Cognitive function; CRC cis rs12922317 0.538 rs446289 chr16:12070486 T/G cg02368508 chr16:12060182 TNFRSF17 -0.44 -6.96 -0.36 1.81e-11 Schizophrenia; CRC trans rs7267979 1.000 rs10966 chr20:25282944 A/G cg17903999 chr18:56338584 MALT1 -0.43 -7.11 -0.36 7.25e-12 Liver enzyme levels (alkaline phosphatase); CRC cis rs2777491 0.957 rs8027626 chr15:41711514 T/G cg18705301 chr15:41695430 NDUFAF1 -0.73 -12.65 -0.57 3.59e-30 Ulcerative colitis; CRC trans rs17730929 0.659 rs1033095 chr4:67232011 A/G cg05901279 chr12:42979568 PRICKLE1 -0.52 -5.99 -0.31 5.55e-9 Colorectal cancer (SNP x SNP interaction); CRC cis rs1046896 0.586 rs9897951 chr17:80810662 T/C cg02711726 chr17:80685570 FN3KRP -0.53 -7.2 -0.37 4.17e-12 Glycated hemoglobin levels; CRC trans rs4942242 0.663 rs9525815 chr13:44223692 T/C cg26741380 chr15:41871084 TYRO3 -0.46 -6.54 -0.34 2.4e-10 Response to tocilizumab in rheumatoid arthritis; CRC cis rs10479542 0.544 rs7706275 chr5:178990305 A/G cg19626725 chr5:178986131 RUFY1 0.36 6.4 0.33 5.45e-10 Lung cancer; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg08117032 chr8:38325144 FGFR1 0.33 6.53 0.34 2.52e-10 Liver disease severity in Alagille syndrome; CRC cis rs6545883 0.929 rs55806663 chr2:61740487 G/T cg15711740 chr2:61764176 XPO1 -0.52 -7.2 -0.37 4.03e-12 Tuberculosis; CRC cis rs10743315 0.778 rs965861 chr12:19360719 A/G cg02471346 chr12:19282374 PLEKHA5 -0.63 -7.93 -0.4 3.37e-14 Gut microbiota (bacterial taxa); CRC cis rs6499255 1.000 rs55992518 chr16:69821407 C/T cg04110750 chr16:69646130 NFAT5 -0.52 -6.83 -0.35 4.06e-11 IgE levels; CRC cis rs875971 0.895 rs3857684 chr7:65938158 G/C cg18912574 chr7:65842487 NCRNA00174 0.36 6.18 0.32 1.88e-9 Aortic root size; CRC cis rs10504229 0.683 rs2318144 chr8:58114743 G/A cg02725872 chr8:58115012 NA -0.58 -8.43 -0.42 1.11e-15 Developmental language disorder (linguistic errors); CRC cis rs1707322 0.721 rs11211178 chr1:46227566 G/T cg03146154 chr1:46216737 IPP 0.66 9.44 0.46 7.2e-19 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs6585424 1.000 rs3851055 chr10:81938096 T/C cg11900509 chr10:81946545 ANXA11 -0.72 -8.86 -0.44 5.08e-17 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs7618915 0.547 rs6762813 chr3:52726695 C/T cg08222913 chr3:52553049 STAB1 -0.34 -6.23 -0.32 1.45e-9 Bipolar disorder; CRC trans rs941408 1.000 rs1736180 chr19:2796021 C/T cg22153745 chr1:153894579 GATAD2B -0.62 -9.5 -0.46 4.44e-19 Total cholesterol levels; CRC cis rs6582630 0.555 rs4601853 chr12:38435569 G/A cg13010199 chr12:38710504 ALG10B 0.47 6.3 0.33 9.81e-10 Drug-induced liver injury (flucloxacillin); CRC trans rs4332037 0.539 rs57148375 chr7:2025001 G/C cg11693508 chr17:37793320 STARD3 0.65 7.74 0.39 1.22e-13 Bipolar disorder; CRC cis rs13108904 0.846 rs12643212 chr4:1224948 A/G cg02018176 chr4:1364513 KIAA1530 0.42 6.85 0.35 3.64e-11 Obesity-related traits; CRC cis rs9640161 0.789 rs60283368 chr7:150023258 G/A cg13722127 chr7:150037890 RARRES2 0.47 7.63 0.39 2.48e-13 Blood protein levels;Circulating chemerin levels; CRC cis rs1008375 0.800 rs35463363 chr4:17613423 G/T cg16339924 chr4:17578868 LAP3 0.55 6.86 0.35 3.33e-11 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs875971 0.862 rs1695820 chr7:65844563 G/A cg00343986 chr7:65444356 GUSB 0.41 5.87 0.31 1.09e-8 Aortic root size; CRC cis rs4268898 0.760 rs11125535 chr2:24528114 T/C cg06627628 chr2:24431161 ITSN2 0.44 6.46 0.34 3.82e-10 Asthma; CRC cis rs9487051 1.000 rs9487051 chr6:109617079 A/G cg21918786 chr6:109611834 NA -0.38 -6.66 -0.34 1.14e-10 Reticulocyte fraction of red cells; CRC trans rs7618501 1.000 rs34614773 chr3:49753003 T/G cg21665057 chr3:196295764 WDR53;FBXO45 -0.86 -16.05 -0.66 3.08e-43 Intelligence (multi-trait analysis); CRC cis rs881375 0.867 rs6478487 chr9:123672777 C/T cg00246817 chr9:123691163 NA -0.45 -5.75 -0.3 2.04e-8 Rheumatoid arthritis; CRC cis rs2573652 1.000 rs2581359 chr15:100513707 A/G cg00587665 chr15:100533223 ADAMTS17 -0.37 -6.37 -0.33 6.23e-10 Height; CRC cis rs10504229 0.679 rs72649115 chr8:58037631 T/G cg22535103 chr8:58192502 C8orf71 -0.72 -7.88 -0.4 4.8e-14 Developmental language disorder (linguistic errors); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg21959181 chr7:150755243 CDK5;SLC4A2 0.43 7.66 0.39 2.12e-13 Liver disease severity in Alagille syndrome; CRC cis rs2050392 0.799 rs303429 chr10:30708441 C/T cg25182066 chr10:30743637 MAP3K8 -0.39 -5.67 -0.3 3.07e-8 Inflammatory bowel disease; CRC cis rs12142240 0.698 rs56130131 chr1:46861306 A/C cg00530320 chr1:46809349 NSUN4 0.58 7.93 0.4 3.44e-14 Menopause (age at onset); CRC cis rs9322193 0.923 rs9767309 chr6:150037943 A/G cg00933542 chr6:150070202 PCMT1 0.3 6.26 0.33 1.17e-9 Lung cancer; CRC cis rs2302729 0.578 rs10848682 chr12:2771756 C/G cg19945202 chr12:2788847 CACNA1C -0.43 -6.93 -0.36 2.28e-11 Sleep quality; CRC trans rs17033702 0.560 rs1607904 chr2:67757780 G/T cg11936311 chr5:178957434 NA -0.31 -6.0 -0.31 5.14e-9 Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for BMI in active individuals; CRC trans rs7726839 0.540 rs72703095 chr5:601789 T/C cg11887960 chr12:57824829 NA 0.59 6.52 0.34 2.61e-10 Obesity-related traits; CRC cis rs9368481 1.000 rs9368481 chr6:26961761 C/T cg12292205 chr6:26970375 C6orf41 -0.74 -11.92 -0.55 1.85e-27 Autism spectrum disorder or schizophrenia; CRC cis rs2108622 0.727 rs3093216 chr19:15987737 A/G cg13772218 chr19:15982569 NA 0.48 6.75 0.35 6.72e-11 Circulating phylloquinone levels;Vitamin E levels;Acenocoumarol maintenance dosage;Response to Vitamin E supplementation;Metabolite levels;Warfarin maintenance dose; CRC cis rs7772486 0.875 rs854148 chr6:146310979 G/C cg23711669 chr6:146136114 FBXO30 0.69 11.69 0.54 1.24e-26 Lobe attachment (rater-scored or self-reported); CRC cis rs1799949 0.930 rs56729776 chr17:41422131 C/T cg23758822 chr17:41437982 NA 0.81 13.63 0.6 7.36e-34 Menopause (age at onset); CRC trans rs3806843 0.868 rs2531345 chr5:140126781 T/G cg06840491 chr10:48416966 GDF2 -0.35 -6.04 -0.32 4.16e-9 Depressive symptoms (multi-trait analysis); CRC trans rs2228479 0.850 rs17226666 chr16:89835401 G/A cg24644049 chr4:85504048 CDS1 0.87 7.12 0.37 7.01e-12 Skin colour saturation; CRC cis rs9486719 0.895 rs34051754 chr6:97007754 A/T cg18709589 chr6:96969512 KIAA0776 -0.52 -5.85 -0.31 1.21e-8 Migraine;Coronary artery disease; CRC cis rs9787249 0.957 rs12086750 chr1:40210468 G/C cg02773041 chr1:40204384 PPIE 0.63 9.54 0.47 3.34e-19 Blood protein levels; CRC cis rs8180040 1.000 rs1638676 chr3:47327651 A/G cg10298567 chr3:47292165 KIF9 -0.4 -6.72 -0.35 7.9e-11 Colorectal cancer; CRC cis rs9291683 0.552 rs17187075 chr4:9990328 G/C cg11266682 chr4:10021025 SLC2A9 0.53 11.06 0.52 2.12e-24 Bone mineral density; CRC cis rs6665290 0.904 rs11586604 chr1:227183865 G/T cg10327440 chr1:227177885 CDC42BPA -1.04 -23.31 -0.79 1.24e-71 Myeloid white cell count; CRC cis rs9486715 0.867 rs9384628 chr6:96960232 T/C cg18709589 chr6:96969512 KIAA0776 0.49 7.2 0.37 4.01e-12 Headache; CRC cis rs7772486 0.692 rs1577916 chr6:146069789 G/A cg13319975 chr6:146136371 FBXO30 0.45 6.58 0.34 1.83e-10 Lobe attachment (rater-scored or self-reported); CRC cis rs898097 0.812 rs72859941 chr17:80837459 G/A cg15369054 chr17:80825471 TBCD 0.53 8.64 0.43 2.55e-16 Breast cancer; CRC cis rs9527 0.641 rs4919684 chr10:104587024 A/G cg15744005 chr10:104629667 AS3MT -0.35 -6.44 -0.33 4.27e-10 Arsenic metabolism; CRC cis rs231513 0.911 rs231515 chr17:41964083 A/G cg26893861 chr17:41843967 DUSP3 -0.65 -6.57 -0.34 1.94e-10 Cognitive function; CRC cis rs67311347 0.866 rs3214006 chr3:40352134 C/T cg09455208 chr3:40491958 NA 0.36 6.93 0.36 2.23e-11 Renal cell carcinoma; CRC cis rs9372498 0.536 rs62422220 chr6:118923731 G/A cg22561889 chr6:118971681 C6orf204 0.5 6.43 0.33 4.49e-10 Diastolic blood pressure; CRC cis rs654950 0.840 rs647146 chr1:41986286 G/A cg06885757 chr1:42089581 HIVEP3 0.37 6.37 0.33 6.37e-10 Airway imaging phenotypes; CRC cis rs12549902 0.800 rs7825494 chr8:41507350 C/T cg17182837 chr8:41585554 ANK1 -0.36 -5.68 -0.3 2.89e-8 Corrected insulin response;Corrected insulin response adjusted for insulin sensitivity index;Insulin levels adjusted for BMI;Type 2 diabetes; CRC cis rs7618501 0.602 rs2013208 chr3:50129399 C/T cg05623727 chr3:50126028 RBM5 -0.46 -7.83 -0.4 6.89e-14 Intelligence (multi-trait analysis); CRC cis rs2425143 0.818 rs7272684 chr20:34424692 C/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.53 -6.01 -0.31 4.96e-9 Blood protein levels; CRC cis rs7312774 0.618 rs7953093 chr12:107334540 G/A cg16260113 chr12:107380972 MTERFD3 0.77 7.72 0.39 1.42e-13 Severe influenza A (H1N1) infection; CRC cis rs4731207 0.591 rs1481336 chr7:124696739 G/C cg23710748 chr7:124431027 NA -0.39 -6.22 -0.32 1.54e-9 Cutaneous malignant melanoma; CRC cis rs4478858 0.735 rs4949382 chr1:31776731 A/G cg07478791 chr1:31886160 SERINC2 -0.4 -5.64 -0.3 3.76e-8 Alcohol dependence; CRC cis rs9399135 0.660 rs9376072 chr6:135280519 G/C cg22676075 chr6:135203613 NA 0.46 7.06 0.36 9.99e-12 Red blood cell count; CRC cis rs1712517 0.740 rs4917387 chr10:105108455 T/C cg05636881 chr10:105038444 INA 0.47 8.05 0.41 1.53e-14 Migraine; CRC cis rs243505 0.660 rs243488 chr7:148446649 G/A cg09806900 chr7:148480153 CUL1 -0.6 -7.47 -0.38 7.52e-13 Inflammatory bowel disease;Crohn's disease; CRC cis rs11155671 0.530 rs7768665 chr6:150208024 G/A cg07701084 chr6:150067640 NUP43 0.49 7.17 0.37 4.95e-12 Testicular germ cell tumor; CRC cis rs8180040 0.966 rs13072802 chr3:47346415 G/C cg02527881 chr3:46936655 PTH1R -0.4 -7.7 -0.39 1.58e-13 Colorectal cancer; CRC cis rs10242455 0.702 rs74416635 chr7:99180569 G/A cg18809830 chr7:99032528 PTCD1 -1.2 -8.67 -0.43 1.94e-16 Blood metabolite levels; CRC cis rs294883 0.858 rs6932095 chr6:159720458 C/T cg14500486 chr6:159655392 FNDC1 -0.35 -5.76 -0.3 1.95e-8 Coronary artery disease; CRC cis rs3764400 0.567 rs12600980 chr17:46187141 C/T cg10706073 chr17:46328419 SKAP1 0.61 6.62 0.34 1.44e-10 Body mass index; CRC cis rs8031584 0.958 rs11637469 chr15:31238783 T/C cg14829155 chr15:31115871 NA -0.5 -8.12 -0.41 9.41e-15 Huntington's disease progression; CRC cis rs1005277 0.579 rs1985707 chr10:38434098 C/T cg17219203 chr10:38645113 HSD17B7P2 -0.4 -5.68 -0.3 2.98e-8 Extrinsic epigenetic age acceleration; CRC cis rs7904368 0.806 rs4612698 chr10:16855070 C/A cg23933602 chr10:16859644 RSU1 0.52 5.8 0.3 1.58e-8 Ratio of the peak velocity of the mitral E-Wave divided by the peak velocity of the mitral A-wave.; CRC cis rs243505 0.732 rs10255478 chr7:148501985 C/G cg09806900 chr7:148480153 CUL1 0.52 7.45 0.38 8.26e-13 Inflammatory bowel disease;Crohn's disease; CRC cis rs7927592 0.871 rs17603185 chr11:68376241 C/T cg16797656 chr11:68205561 LRP5 0.36 5.71 0.3 2.49e-8 Total body bone mineral density; CRC cis rs12188164 0.561 rs2251843 chr5:457955 C/T cg21625146 chr5:486483 SLC9A3 -0.37 -5.69 -0.3 2.77e-8 Cystic fibrosis severity; CRC cis rs514406 0.621 rs2003250 chr1:53196666 T/C cg25767906 chr1:53392781 SCP2 0.42 6.66 0.34 1.15e-10 Monocyte count; CRC cis rs7212938 0.509 rs62068170 chr17:38103210 G/A cg26162295 chr17:38119207 GSDMA -0.36 -6.54 -0.34 2.4e-10 Asthma and hay fever; CRC cis rs992157 0.717 rs3817266 chr2:219142594 C/T cg04731861 chr2:219085781 ARPC2 0.33 6.95 0.36 2.01e-11 Colorectal cancer; CRC cis rs796364 0.901 rs35572201 chr2:201035093 T/C cg25936922 chr2:200820526 C2orf60;C2orf47 -0.64 -6.72 -0.35 8.06e-11 Schizophrenia; CRC cis rs1799949 1.000 rs4793192 chr17:41204390 T/C cg19454999 chr17:41278357 BRCA1;NBR2 0.54 8.53 0.43 5.37e-16 Menopause (age at onset); CRC cis rs870825 0.616 rs2141257 chr4:185609463 C/T cg07424746 chr4:185654737 MLF1IP 0.61 6.07 0.32 3.48e-9 Blood protein levels; CRC cis rs916888 0.610 rs199452 chr17:44801340 C/T cg15921436 chr17:44337874 NA 0.51 6.78 0.35 5.45e-11 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs10876993 0.928 rs2640631 chr12:58067532 A/T cg18357645 chr12:58087776 OS9 0.58 8.42 0.42 1.19e-15 Celiac disease or Rheumatoid arthritis; CRC cis rs9818758 0.607 rs9880088 chr3:49178990 G/A cg00383909 chr3:49044727 WDR6 1.12 10.64 0.51 6.59e-23 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; CRC cis rs736408 0.609 rs62255396 chr3:52782839 C/T cg05573699 chr3:52720067 GNL3;PBRM1 -0.46 -6.49 -0.34 3.08e-10 Bipolar disorder; CRC cis rs11997175 0.545 rs66783231 chr8:33811467 A/T cg04338863 chr8:33670619 NA 0.41 6.18 0.32 1.86e-9 Body mass index; CRC cis rs7607369 0.559 rs13002060 chr2:219660394 G/T cg02176678 chr2:219576539 TTLL4 -0.39 -6.16 -0.32 2.15e-9 Red blood cell count;Amyotrophic lateral sclerosis; CRC cis rs2842992 0.789 rs2146163 chr6:160224346 T/C cg11366901 chr6:160182831 ACAT2 0.97 13.91 0.61 6.76e-35 Age-related macular degeneration (geographic atrophy); CRC cis rs6662572 1.000 rs72688452 chr1:46092365 G/A cg08644498 chr1:46502608 NA 0.45 6.6 0.34 1.68e-10 Blood protein levels; CRC cis rs3849570 0.533 rs6548782 chr3:81993287 T/G cg07356753 chr3:81810745 GBE1 -0.48 -6.4 -0.33 5.35e-10 Waist circumference;Body mass index; CRC cis rs7208859 0.673 rs450585 chr17:28951039 G/A cg01831904 chr17:28903510 LRRC37B2 -0.54 -6.58 -0.34 1.81e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC trans rs11039798 0.557 rs4441015 chr11:49027070 A/G cg15704280 chr7:45808275 SEPT13 0.67 6.81 0.35 4.59e-11 Axial length; CRC cis rs2949837 0.581 rs1852210 chr7:45994256 C/T cg04727332 chr7:45960243 IGFBP3 0.36 5.65 0.3 3.46e-8 Sitting height ratio; CRC cis rs2032447 0.839 rs199750 chr6:26016462 A/G cg18357526 chr6:26021779 HIST1H4A -0.79 -12.07 -0.55 5.09e-28 Intelligence (multi-trait analysis); CRC cis rs72634258 0.945 rs225131 chr1:8095486 T/C cg00042356 chr1:8021962 PARK7 0.56 6.89 0.35 2.92e-11 Inflammatory bowel disease; CRC cis rs2836974 0.932 rs6517527 chr21:40581751 G/A cg11644478 chr21:40555479 PSMG1 0.81 12.39 0.56 3.3600000000000003e-29 Cognitive function; CRC cis rs875971 0.929 rs12535036 chr7:65964063 G/T cg12463550 chr7:65579703 CRCP 0.47 6.79 0.35 5.17e-11 Aortic root size; CRC trans rs7615952 0.641 rs66520539 chr3:125780374 G/A cg07211511 chr3:129823064 LOC729375 -0.72 -9.7 -0.47 9.79e-20 Blood pressure (smoking interaction); CRC cis rs4654899 0.802 rs12137203 chr1:21109088 T/A cg02927042 chr1:21476669 EIF4G3 -0.44 -6.89 -0.36 2.87e-11 Superior frontal gyrus grey matter volume; CRC cis rs7617773 0.539 rs17593974 chr3:48387334 G/T cg11946769 chr3:48343235 NME6 0.61 8.38 0.42 1.54e-15 Coronary artery disease; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg19752117 chr17:4850710 PFN1 0.53 7.51 0.38 5.54e-13 Response to antipsychotic treatment; CRC cis rs7809950 1.000 rs4730245 chr7:107087294 C/T cg23024343 chr7:107201750 COG5 -0.62 -8.74 -0.43 1.21e-16 Coronary artery disease; CRC cis rs763121 0.853 rs3747172 chr22:39067524 A/G cg06544989 chr22:39130855 UNC84B 0.45 6.83 0.35 4.13e-11 Menopause (age at onset); CRC cis rs72901758 0.768 rs11657271 chr17:76249682 A/T cg26068271 chr17:76253126 NA 0.37 5.61 0.3 4.29e-8 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells; CRC cis rs6500602 0.701 rs1362626 chr16:4549226 C/G cg08645402 chr16:4508243 NA 0.59 9.97 0.48 1.27e-20 Schizophrenia; CRC cis rs704795 0.775 rs4665975 chr2:27626017 A/T cg24768116 chr2:27665128 KRTCAP3 -0.36 -7.65 -0.39 2.17e-13 Menopause (age at onset); CRC cis rs7937682 0.889 rs7948236 chr11:111499933 C/A cg19812747 chr11:111475976 SIK2 -0.56 -9.35 -0.46 1.41e-18 Primary sclerosing cholangitis; CRC cis rs11764590 0.813 rs11768212 chr7:1992582 A/C cg24505167 chr7:1915268 MAD1L1 -0.4 -5.81 -0.3 1.51e-8 Neuroticism; CRC cis rs3733585 0.673 rs4314284 chr4:9956096 C/T cg11266682 chr4:10021025 SLC2A9 -0.47 -9.58 -0.47 2.55e-19 Cleft plate (environmental tobacco smoke interaction); CRC cis rs597539 0.654 rs7107137 chr11:68623712 A/G cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.85 13.61 0.6 9.15e-34 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs6921919 0.848 rs9468350 chr6:28319107 A/G cg21251018 chr6:28226885 NKAPL 0.42 6.22 0.32 1.55e-9 Autism spectrum disorder or schizophrenia; CRC cis rs4072980 0.545 rs11210870 chr1:38449910 T/C cg12658694 chr1:38397304 INPP5B -0.59 -7.95 -0.4 2.92e-14 Coronary artery disease; CRC cis rs3741404 0.791 rs7112960 chr11:63907079 A/G cg05016508 chr11:63871570 FLRT1;MACROD1 0.44 6.53 0.34 2.55e-10 Platelet count; CRC cis rs9487051 0.872 rs9400271 chr6:109607556 G/A cg21918786 chr6:109611834 NA -0.44 -8.05 -0.41 1.56e-14 Reticulocyte fraction of red cells; CRC cis rs1042058 0.565 rs650110 chr10:30753132 A/G cg25182066 chr10:30743637 MAP3K8 -0.51 -7.12 -0.37 6.72e-12 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; CRC cis rs12586317 0.513 rs74564132 chr14:35472882 C/T cg16230307 chr14:35515116 FAM177A1 0.85 9.81 0.48 4.4e-20 Psoriasis; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg06076054 chr21:19191045 C21orf91 0.48 6.82 0.35 4.42e-11 Response to antipsychotic treatment; CRC cis rs17001868 0.568 rs3788578 chr22:40742921 C/T cg07138101 chr22:40742427 ADSL 0.59 7.8 0.4 8.21e-14 Mammographic density (dense area); CRC cis rs4713118 0.955 rs9468203 chr6:27688667 A/G cg26587870 chr6:27730563 NA -0.42 -6.27 -0.33 1.16e-9 Parkinson's disease; CRC cis rs13191362 1.000 rs36007635 chr6:163009335 G/A cg21926612 chr6:163149169 PACRG;PARK2 0.78 10.8 0.51 1.77e-23 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs12142240 0.659 rs72677602 chr1:46837487 G/A cg00530320 chr1:46809349 NSUN4 0.56 7.25 0.37 2.98e-12 Menopause (age at onset); CRC cis rs35146811 0.735 rs7811662 chr7:99792608 A/G cg00553149 chr7:99775558 STAG3;GPC2 0.24 5.79 0.3 1.63e-8 Coronary artery disease; CRC cis rs10504229 0.683 rs35889486 chr8:58117749 T/A cg22535103 chr8:58192502 C8orf71 -0.7 -9.34 -0.46 1.47e-18 Developmental language disorder (linguistic errors); CRC cis rs2477686 0.526 rs1998760 chr1:2397136 C/T cg13556452 chr1:2391241 NA -0.36 -5.75 -0.3 2.08e-8 Non-obstructive azoospermia; CRC cis rs2304069 0.545 rs4705404 chr5:149381952 A/C cg22760475 chr5:149380129 HMGXB3;TIGD6 0.47 6.81 0.35 4.78e-11 HIV-1 control; CRC cis rs8078723 1.000 rs6503530 chr17:38161823 T/C cg17344932 chr17:38183730 MED24;SNORD124 -0.45 -6.93 -0.36 2.24e-11 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); CRC cis rs7647973 0.588 rs62262675 chr3:49673662 A/G cg13072238 chr3:49761600 GMPPB 0.56 6.07 0.32 3.43e-9 Menarche (age at onset); CRC cis rs17253792 0.822 rs77555779 chr14:56078430 A/G cg01858014 chr14:56050164 KTN1 -0.87 -7.23 -0.37 3.34e-12 Putamen volume; CRC cis rs9796 0.621 rs1659227 chr15:41472398 G/A cg18705301 chr15:41695430 NDUFAF1 0.41 6.82 0.35 4.3e-11 Menopause (age at onset); CRC cis rs7666738 0.830 rs28515641 chr4:98726419 G/A cg17366294 chr4:99064904 C4orf37 0.42 6.91 0.36 2.59e-11 Colonoscopy-negative controls vs population controls; CRC cis rs1552244 1.000 rs7651058 chr3:10066964 C/T cg16606324 chr3:10149918 C3orf24 0.69 9.39 0.46 1e-18 Alzheimer's disease; CRC cis rs2985684 0.802 rs10150823 chr14:50051751 C/T cg23565292 chr14:50234668 KLHDC2 -0.44 -6.21 -0.32 1.57e-9 Carotid intima media thickness; CRC cis rs10791323 0.569 rs2298738 chr11:133715153 G/C cg03690763 chr11:133734501 NA -0.36 -5.97 -0.31 6.21e-9 Childhood ear infection; CRC cis rs6502050 0.712 rs8077079 chr17:80059011 C/T cg25804541 chr17:80189381 SLC16A3 0.3 5.68 0.3 3.02e-8 Life satisfaction; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg13338022 chr15:43029438 CDAN1 0.46 6.56 0.34 2.05e-10 Response to antipsychotic treatment; CRC cis rs7927592 0.913 rs59056571 chr11:68272973 T/G cg01657329 chr11:68192670 LRP5 -0.46 -6.47 -0.34 3.53e-10 Total body bone mineral density; CRC cis rs4332037 0.539 rs56305291 chr7:2048706 A/G cg13880726 chr7:1868755 MAD1L1 -0.46 -5.63 -0.3 3.89e-8 Bipolar disorder; CRC trans rs9825823 0.617 rs2083264 chr3:61074229 A/G cg25224543 chr5:52405696 MOCS2 0.4 6.04 0.32 4.14e-9 Depressive symptom measurement or major depressive disorder; CRC cis rs10504229 0.728 rs17215851 chr8:58154160 A/C cg02725872 chr8:58115012 NA -0.57 -9.07 -0.45 1.09e-17 Developmental language disorder (linguistic errors); CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg20848390 chr8:59465780 SDCBP 0.47 6.73 0.35 7.48e-11 Anxiety disorder; CRC cis rs514406 0.800 rs7548519 chr1:53294473 A/G cg24675658 chr1:53192096 ZYG11B -0.57 -8.88 -0.44 4.55e-17 Monocyte count; CRC cis rs9868809 0.881 rs2286652 chr3:48689192 G/A cg07636037 chr3:49044803 WDR6 -0.64 -5.94 -0.31 7.37e-9 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; CRC cis rs4731207 0.698 rs4731222 chr7:124481635 G/A cg23710748 chr7:124431027 NA 0.38 6.08 0.32 3.42e-9 Cutaneous malignant melanoma; CRC cis rs7113874 0.589 rs11041944 chr11:8500996 G/A cg17679104 chr11:8615758 STK33 0.35 5.83 0.31 1.33e-8 Body mass index in physically active individuals;Body mass index (joint analysis main effects and physical activity interaction); CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg11252337 chr19:2273843 NA 0.45 6.21 0.32 1.63e-9 Thyroid stimulating hormone; CRC cis rs4713118 0.868 rs10484401 chr6:27746590 A/T cg02683197 chr6:28174875 NA -0.66 -7.2 -0.37 4.16e-12 Parkinson's disease; CRC cis rs4555082 0.957 rs2816608 chr14:105718407 A/G cg18132624 chr14:105716052 BTBD6;BRF1 0.37 6.2 0.32 1.72e-9 Mean platelet volume;Platelet distribution width; CRC cis rs798554 0.757 rs1182179 chr7:2873648 A/G cg14895029 chr7:2775587 GNA12 -0.43 -6.2 -0.32 1.72e-9 Height; CRC cis rs8062405 1.000 rs9972693 chr16:28859802 A/G cg08761264 chr16:28874980 SH2B1 -0.44 -5.84 -0.31 1.27e-8 Cognitive ability (multi-trait analysis);Cognitive ability; CRC cis rs6909279 0.678 rs9479056 chr6:151848899 C/A cg10883421 chr6:151773342 RMND1;C6orf211 -0.44 -6.68 -0.35 1.02e-10 Bone mineral density; CRC cis rs2380220 0.541 rs9285413 chr6:96023439 G/A cg04719120 chr6:96025338 MANEA 0.73 9.32 0.46 1.71e-18 Behavioural disinhibition (generation interaction); CRC cis rs35110281 0.591 rs162366 chr21:44935383 C/T cg04455712 chr21:45112962 RRP1B -0.4 -7.63 -0.39 2.53e-13 Mean corpuscular volume; CRC cis rs9768139 0.708 rs10234067 chr7:158114542 C/T cg24154853 chr7:158122151 PTPRN2 0.59 9.88 0.48 2.43e-20 Calcium levels; CRC cis rs1572438 1.000 rs873559 chr6:875336 G/A cg13447295 chr6:887704 NA 0.44 6.25 0.33 1.25e-9 Aging; CRC cis rs9837602 0.938 rs9873709 chr3:99711687 G/A cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G 0.46 5.6 0.3 4.47e-8 Breast cancer; CRC cis rs4819052 1.000 rs4818769 chr21:46667451 C/T cg19498844 chr21:46707878 POFUT2;LOC642852 0.84 10.97 0.52 4.37e-24 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC trans rs6703335 0.870 rs10803142 chr1:243598234 A/G cg19325359 chr11:85955589 EED 0.43 6.12 0.32 2.64e-9 Schizophrenia;Schizophrenia, schizoaffective disorder or bipolar disorder; CRC trans rs4332037 0.707 rs62435130 chr7:1890002 C/T cg11693508 chr17:37793320 STARD3 0.64 8.24 0.41 4.16e-15 Bipolar disorder; CRC cis rs2836974 0.568 rs7282604 chr21:40536910 C/T cg11890956 chr21:40555474 PSMG1 -0.94 -16.8 -0.68 3.46e-46 Cognitive function; CRC cis rs6460942 0.730 rs7780477 chr7:12233750 G/C cg06484146 chr7:12443880 VWDE -0.58 -6.08 -0.32 3.36e-9 Coronary artery disease; CRC cis rs6088580 0.619 rs1205335 chr20:32927507 C/T cg24642439 chr20:33292090 TP53INP2 -0.4 -6.78 -0.35 5.44e-11 Glomerular filtration rate (creatinine); CRC cis rs2075371 0.932 rs1035328 chr7:133978419 T/C cg20476274 chr7:133979776 SLC35B4 0.78 13.98 0.61 3.45e-35 Mean platelet volume; CRC cis rs9768139 0.708 rs10234067 chr7:158114542 C/T cg23298862 chr7:158159286 PTPRN2 0.39 6.16 0.32 2.1e-9 Calcium levels; CRC trans rs2303319 0.504 rs12467613 chr2:162603216 G/T cg12500891 chr11:57225987 NA -0.65 -6.06 -0.32 3.77e-9 Cognitive function; CRC cis rs995000 0.931 rs998403 chr1:62928549 G/A cg19896129 chr1:63156450 NA 0.4 5.91 0.31 8.41e-9 Triglyceride levels; CRC cis rs12024301 0.557 rs114086623 chr1:183648626 G/T cg11505048 chr1:183622726 RGL1;APOBEC4 0.71 6.24 0.33 1.33e-9 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs2276314 0.857 rs9304155 chr18:33585710 A/C cg05985134 chr18:33552581 C18orf21 0.49 6.76 0.35 6.12e-11 Endometriosis;Drug-induced torsades de pointes; CRC cis rs9467773 0.967 rs9467775 chr6:26513435 G/A cg09904177 chr6:26538194 HMGN4 0.86 14.68 0.63 7.08e-38 Intelligence (multi-trait analysis); CRC cis rs881375 1.000 rs4323544 chr9:123647377 C/T cg00246817 chr9:123691163 NA -0.47 -5.9 -0.31 9.04e-9 Rheumatoid arthritis; CRC cis rs9611565 0.681 rs5751094 chr22:41803279 C/T cg06634786 chr22:41940651 POLR3H 0.62 7.15 0.37 5.6e-12 Vitiligo; CRC cis rs9326248 0.559 rs476399 chr11:116733728 T/C cg20608306 chr11:116969690 SIK3 0.33 6.88 0.35 3.07e-11 Blood protein levels; CRC cis rs1580019 0.961 rs766657 chr7:32499510 A/G cg07520158 chr7:32535189 LSM5;AVL9 0.46 6.52 0.34 2.6e-10 Cognitive ability; CRC cis rs35306767 0.903 rs12240651 chr10:943656 A/G cg26597838 chr10:835615 NA 0.97 11.62 0.54 2.17e-26 Eosinophil percentage of granulocytes; CRC cis rs490234 0.676 rs13299008 chr9:128213966 T/G cg14078157 chr9:128172775 NA -0.37 -6.15 -0.32 2.19e-9 Mean arterial pressure; CRC cis rs7089973 0.604 rs11196947 chr10:116601372 G/A cg23260525 chr10:116636907 FAM160B1 0.35 8.13 0.41 8.85e-15 Bipolar disorder or attention deficit hyperactivity disorder; CRC cis rs7666738 0.962 rs2865985 chr4:99068009 T/C cg05340658 chr4:99064831 C4orf37 0.53 7.46 0.38 7.87e-13 Colonoscopy-negative controls vs population controls; CRC cis rs7615952 0.599 rs1044215 chr3:125725559 C/G cg05084668 chr3:125655381 ALG1L -0.52 -8.43 -0.42 1.13e-15 Blood pressure (smoking interaction); CRC cis rs17162190 0.698 rs12086684 chr1:26837067 C/A cg17456097 chr1:26900765 RPS6KA1 0.42 6.18 0.32 1.94e-9 Mean corpuscular volume; CRC cis rs7208859 0.623 rs8079891 chr17:29058863 G/A cg01831904 chr17:28903510 LRRC37B2 -0.61 -6.22 -0.32 1.52e-9 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs123509 0.687 rs6865 chr3:42826041 A/C cg12982090 chr3:42733453 KBTBD5 -0.56 -6.83 -0.35 4.16e-11 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs12983728 0.831 rs79222418 chr19:58664418 T/C cg24884572 chr19:58661833 ZNF329 0.75 8.23 0.41 4.52e-15 Cholesterol, total; CRC cis rs990171 1.000 rs1420106 chr2:103035044 C/T cg03938978 chr2:103052716 IL18RAP -0.43 -5.61 -0.3 4.3e-8 Lymphocyte counts; CRC cis rs847649 0.692 rs6949391 chr7:102446863 C/T cg18108683 chr7:102477205 FBXL13 -0.67 -11.29 -0.53 3.37e-25 Morning vs. evening chronotype; CRC trans rs12310956 0.532 rs11608842 chr12:33951121 C/T cg26384229 chr12:38710491 ALG10B 0.44 6.06 0.32 3.64e-9 Morning vs. evening chronotype; CRC cis rs9914988 0.943 rs11656256 chr17:27153553 G/A cg16670446 chr17:27188758 MIR451;MIR144 0.53 8.4 0.42 1.32e-15 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs7772486 0.846 rs7755440 chr6:146375906 T/C cg13319975 chr6:146136371 FBXO30 -0.39 -5.97 -0.31 6.13e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs4363385 0.574 rs4845503 chr1:152959939 A/G cg25856811 chr1:152973957 SPRR3 -0.24 -6.63 -0.34 1.39e-10 Inflammatory skin disease; CRC cis rs9287719 0.781 rs6732671 chr2:10759149 T/G cg00105475 chr2:10696890 NA 0.45 7.12 0.37 6.81e-12 Prostate cancer; CRC cis rs6693567 0.565 rs1776273 chr1:150270209 C/T cg15654264 chr1:150340011 RPRD2 0.37 5.67 0.3 3.11e-8 Migraine; CRC cis rs6502050 0.865 rs56193110 chr17:80151501 A/G cg02741985 chr17:80059408 CCDC57 0.44 7.33 0.37 1.76e-12 Life satisfaction; CRC cis rs67385638 0.862 rs11036641 chr11:5310578 A/G cg21506790 chr11:5277210 HBG2 0.36 5.77 0.3 1.85e-8 Hemoglobin levels; CRC cis rs8060686 0.920 rs55661503 chr16:67836552 T/A cg19582491 chr16:67682965 RLTPR -0.58 -6.92 -0.36 2.32e-11 HDL cholesterol;Metabolic syndrome; CRC cis rs4555082 0.874 rs113291192 chr14:105738181 C/T cg10792982 chr14:105748885 BRF1 0.38 6.37 0.33 6.36e-10 Mean platelet volume;Platelet distribution width; CRC cis rs561341 0.941 rs736678 chr17:30347423 G/T cg23018236 chr17:30244563 NA -0.67 -8.11 -0.41 9.97e-15 Hip circumference adjusted for BMI; CRC cis rs1008375 0.966 rs7658240 chr4:17588950 A/G cg16339924 chr4:17578868 LAP3 -0.68 -8.9 -0.44 3.69e-17 Parasitemia in Tripanosoma cruzi seropositivity; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg10089324 chr1:51984752 EPS15 0.51 6.66 0.34 1.13e-10 Thyroid stimulating hormone; CRC cis rs600231 0.708 rs1784100 chr11:65249227 T/C cg17120908 chr11:65337727 SSSCA1 -0.58 -8.72 -0.43 1.38e-16 Bone mineral density; CRC cis rs6500602 0.702 rs11076835 chr16:4549618 G/A cg08645402 chr16:4508243 NA 0.59 10.24 0.49 1.58e-21 Schizophrenia; CRC cis rs10504229 1.000 rs72650892 chr8:58179714 A/G cg22535103 chr8:58192502 C8orf71 -0.82 -12.27 -0.56 9.63e-29 Developmental language disorder (linguistic errors); CRC cis rs9660992 0.512 rs12123773 chr1:205122420 C/G cg03948781 chr1:205179583 DSTYK 0.42 5.85 0.31 1.2e-8 Mean corpuscular volume;Mean platelet volume; CRC trans rs7618501 0.633 rs2008877 chr3:50162291 T/G cg21659725 chr3:3221576 CRBN -0.59 -9.16 -0.45 5.83e-18 Intelligence (multi-trait analysis); CRC cis rs7208859 0.623 rs55814012 chr17:29077697 T/A cg01831904 chr17:28903510 LRRC37B2 -0.62 -6.42 -0.33 4.72e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC trans rs11098499 0.866 rs12501602 chr4:120287935 A/T cg25214090 chr10:38739885 LOC399744 0.61 9.55 0.47 3.06e-19 Corneal astigmatism; CRC cis rs2404602 0.647 rs907594 chr15:77197745 C/A cg23625390 chr15:77176239 SCAPER -0.89 -14.16 -0.62 7.2e-36 Blood metabolite levels; CRC cis rs6502050 0.835 rs3935129 chr17:80113381 G/C cg22110888 chr17:80059540 CCDC57 0.4 6.44 0.33 4.17e-10 Life satisfaction; CRC cis rs6952808 0.692 rs11765549 chr7:2027311 G/T cg21782813 chr7:2030301 MAD1L1 0.54 9.09 0.45 9.59e-18 Bipolar disorder and schizophrenia; CRC cis rs6738825 0.606 rs10931784 chr2:198405636 T/A cg10820045 chr2:198174542 NA 0.34 6.08 0.32 3.36e-9 Crohn's disease; CRC cis rs7772486 0.686 rs2142983 chr6:146069701 G/C cg13319975 chr6:146136371 FBXO30 0.43 6.48 0.34 3.33e-10 Lobe attachment (rater-scored or self-reported); CRC trans rs12188164 0.686 rs72711365 chr5:416672 G/A cg15371732 chr17:78194151 SLC26A11;SGSH 0.43 6.11 0.32 2.74e-9 Cystic fibrosis severity; CRC cis rs6540559 0.546 rs735693 chr1:210033988 A/C cg22029157 chr1:209979665 IRF6 0.65 7.86 0.4 5.53e-14 Cleft lip with or without cleft palate; CRC cis rs2836974 0.932 rs2836955 chr21:40619887 G/A cg17971929 chr21:40555470 PSMG1 0.74 10.16 0.49 2.75e-21 Cognitive function; CRC cis rs939584 1.000 rs13396935 chr2:653195 G/A cg03610516 chr2:642275 NA -0.42 -5.78 -0.3 1.75e-8 Body mass index; CRC cis rs4423214 0.592 rs7120029 chr11:71198957 G/A cg05163923 chr11:71159392 DHCR7 -0.54 -5.92 -0.31 8.16e-9 Vitamin D levels; CRC cis rs9682041 0.660 rs13089256 chr3:170113601 G/A cg11886554 chr3:170076028 SKIL 0.7 8.33 0.42 2.21e-15 Glomerular filtration rate in non diabetics (creatinine);Glomerular filtration rate (creatinine); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg23721301 chr10:112064230 SMNDC1 0.4 6.5 0.34 2.95e-10 Liver disease severity in Alagille syndrome; CRC cis rs1023500 0.505 rs134899 chr22:42683030 T/G cg05082376 chr22:42548792 NA -0.36 -5.83 -0.31 1.3e-8 Schizophrenia; CRC cis rs1005277 0.541 rs2263163 chr10:38389887 G/A cg25427524 chr10:38739819 LOC399744 -0.76 -13.43 -0.59 4.45e-33 Extrinsic epigenetic age acceleration; CRC cis rs9322193 0.923 rs9505982 chr6:149939601 G/A cg05861140 chr6:150128134 PCMT1 -0.36 -5.85 -0.31 1.17e-8 Lung cancer; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg03274021 chr8:130952480 FAM49B 0.47 6.04 0.32 4.24e-9 Thyroid stimulating hormone; CRC cis rs7959452 0.557 rs899224 chr12:69784774 A/G cg20891283 chr12:69753455 YEATS4 0.91 17.31 0.69 3.38e-48 Blood protein levels; CRC cis rs1506636 0.646 rs805779 chr7:123214835 C/T cg03229431 chr7:123269106 ASB15 -0.59 -8.55 -0.43 4.56e-16 Plateletcrit;Platelet count; CRC cis rs12101261 0.580 rs3783949 chr14:81448382 A/C cg06600135 chr14:81408086 NA 0.4 5.93 0.31 7.69e-9 Graves' disease; CRC cis rs12760731 0.582 rs6700741 chr1:178566386 C/T cg00404053 chr1:178313656 RASAL2 0.56 6.81 0.35 4.69e-11 Obesity-related traits; CRC cis rs17376456 0.569 rs2045021 chr5:93224222 G/A cg21475434 chr5:93447410 FAM172A -0.49 -6.16 -0.32 2.1e-9 Diabetic retinopathy; CRC cis rs924607 1.000 rs4045344 chr5:595870 G/T cg04476341 chr5:669733 TPPP -0.42 -6.87 -0.35 3.14e-11 Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia; CRC cis rs3540 0.960 rs6496675 chr15:90982756 C/T cg04176472 chr15:90893244 GABARAPL3 0.37 6.48 0.34 3.42e-10 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; CRC cis rs7727544 0.716 rs72793283 chr5:131566941 G/A cg22638593 chr5:131593259 PDLIM4 0.35 6.39 0.33 5.71e-10 Blood metabolite levels; CRC cis rs6496044 0.568 rs1982742 chr15:86068750 A/G cg17133734 chr15:86042851 AKAP13 0.39 6.31 0.33 9.23e-10 Interstitial lung disease; CRC cis rs11971779 0.941 rs6954453 chr7:139031794 C/T cg07862535 chr7:139043722 LUC7L2 1.04 12.45 0.57 2.04e-29 Diisocyanate-induced asthma; CRC cis rs6951245 1.000 rs77760339 chr7:1083927 G/T cg26224354 chr7:1096374 C7orf50;GPR146 -0.89 -11.19 -0.53 7.61e-25 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC trans rs10489849 0.730 rs72713603 chr1:159231430 T/C cg11166453 chr1:247681781 NA -0.39 -6.04 -0.32 4.22e-9 Select biomarker traits; CRC cis rs12142240 0.698 rs1057533 chr1:46815836 C/T cg14993813 chr1:46806288 NSUN4 -0.5 -6.4 -0.33 5.38e-10 Menopause (age at onset); CRC cis rs4700695 0.764 rs27701 chr5:65377526 G/C cg21114390 chr5:65439923 SFRS12 -0.48 -6.15 -0.32 2.19e-9 Facial morphology (factor 19); CRC cis rs71403859 0.502 rs12927456 chr16:71505706 A/G cg08717414 chr16:71523259 ZNF19 -1.0 -10.54 -0.5 1.39e-22 Post bronchodilator FEV1; CRC cis rs17443541 0.507 rs4675697 chr2:200450808 C/T cg03741458 chr2:200468445 NA -0.38 -6.11 -0.32 2.76e-9 Intelligence (multi-trait analysis); CRC cis rs34779708 0.931 rs34304999 chr10:35365705 C/T cg03585969 chr10:35415529 CREM 0.65 8.64 0.43 2.53e-16 Inflammatory bowel disease;Crohn's disease; CRC cis rs7666738 1.000 rs35066600 chr4:98991066 C/A cg17366294 chr4:99064904 C4orf37 0.45 7.35 0.38 1.62e-12 Colonoscopy-negative controls vs population controls; CRC cis rs1552244 0.832 rs115415687 chr3:10195704 C/T cg00166722 chr3:10149974 C3orf24 0.68 7.84 0.4 6.29e-14 Alzheimer's disease; CRC cis rs561341 0.505 rs548298 chr17:30297494 C/A cg12193833 chr17:30244370 NA -0.62 -7.94 -0.4 3.33e-14 Hip circumference adjusted for BMI; CRC cis rs6951245 1.000 rs74347384 chr7:1072440 G/A cg24642844 chr7:1081250 C7orf50 -0.78 -9.35 -0.46 1.42e-18 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs17401966 0.537 rs3748575 chr1:10342352 C/T cg19773385 chr1:10388646 KIF1B -0.47 -7.45 -0.38 8.53e-13 Hepatocellular carcinoma; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg12199425 chr5:90676154 LOC100129716;ARRDC3 0.42 6.07 0.32 3.46e-9 Anxiety disorder; CRC cis rs12479064 0.724 rs6748200 chr2:100080895 G/A cg26064155 chr2:99771622 LIPT1;TSGA10 -0.65 -7.95 -0.4 2.95e-14 Chronic sinus infection; CRC cis rs10504229 0.906 rs7003276 chr8:58173089 A/T cg24829409 chr8:58192753 C8orf71 -0.67 -11.37 -0.53 1.7e-25 Developmental language disorder (linguistic errors); CRC cis rs9796 0.558 rs8043253 chr15:41503730 C/T cg18705301 chr15:41695430 NDUFAF1 -0.42 -6.95 -0.36 1.95e-11 Menopause (age at onset); CRC cis rs6665290 0.901 rs2104860 chr1:227208637 G/C cg10327440 chr1:227177885 CDC42BPA -0.92 -17.94 -0.7 1.17e-50 Myeloid white cell count; CRC cis rs56307353 0.753 rs34318825 chr19:1961342 T/C cg08800497 chr19:1970008 CSNK1G2 0.58 9.13 0.45 7.36e-18 Coronary artery disease; CRC cis rs7618915 0.501 rs35526119 chr3:52749334 C/T cg18404041 chr3:52824283 ITIH1 -0.4 -8.28 -0.42 3.21e-15 Bipolar disorder; CRC cis rs929596 0.574 rs75444879 chr2:234587848 G/A cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.48 -7.48 -0.38 7.04e-13 Total bilirubin levels in HIV-1 infection; CRC cis rs6448317 0.954 rs11946846 chr4:24922703 G/A cg21108841 chr4:24914750 CCDC149 -0.46 -5.97 -0.31 6.22e-9 Heschl's gyrus morphology; CRC cis rs13256369 0.951 rs12679360 chr8:8566269 G/T cg18904891 chr8:8559673 CLDN23 -0.48 -6.22 -0.32 1.49e-9 Obesity-related traits; CRC cis rs10782582 0.593 rs12130832 chr1:76234294 T/C cg10523679 chr1:76189770 ACADM -0.44 -6.3 -0.33 9.35e-10 Daytime sleep phenotypes; CRC cis rs6500602 0.964 rs2896893 chr16:4478559 T/A cg08645402 chr16:4508243 NA 0.53 8.9 0.44 3.75e-17 Schizophrenia; CRC cis rs9525927 0.570 rs9533797 chr13:44799368 A/C cg19190762 chr13:44806055 NA 0.52 6.63 0.34 1.34e-10 Dupuytren's disease; CRC cis rs2354432 0.607 rs7537279 chr1:146673642 A/G cg25205988 chr1:146714368 CHD1L 1.12 9.41 0.46 8.98e-19 Mitochondrial DNA levels; CRC cis rs9894429 0.550 rs6565617 chr17:79612333 G/A cg13777783 chr17:79615861 NA -0.3 -5.64 -0.3 3.71e-8 Eye color traits; CRC cis rs9488822 0.676 rs11153593 chr6:116335131 C/A cg26893134 chr6:116381904 FRK 0.27 7.73 0.39 1.33e-13 Cholesterol, total;LDL cholesterol; CRC cis rs7107174 1.000 rs10899491 chr11:78106305 T/C cg02023728 chr11:77925099 USP35 0.47 7.13 0.37 6.6e-12 Testicular germ cell tumor; CRC cis rs7412746 0.658 rs6669855 chr1:150861229 C/T cg10589385 chr1:150898437 SETDB1 0.34 7.05 0.36 1.03e-11 Melanoma; CRC cis rs17376456 0.825 rs10054790 chr5:93272520 A/G cg21475434 chr5:93447410 FAM172A 0.83 7.88 0.4 4.83e-14 Diabetic retinopathy; CRC cis rs883565 0.569 rs784508 chr3:39166484 C/T cg01426195 chr3:39028469 NA 0.42 6.99 0.36 1.56e-11 Handedness; CRC cis rs9902453 0.765 rs2729440 chr17:28106874 T/A cg26525008 chr17:28256777 EFCAB5;SSH2 -0.72 -12.11 -0.56 3.76e-28 Coffee consumption (cups per day); CRC cis rs9486719 1.000 rs12529248 chr6:96895377 T/G cg06623918 chr6:96969491 KIAA0776 -0.81 -9.51 -0.46 4.17e-19 Migraine;Coronary artery disease; CRC cis rs6879260 1.000 rs7706951 chr5:179733407 C/T cg23248424 chr5:179741104 GFPT2 -0.61 -9.31 -0.46 1.92e-18 Height; CRC trans rs66573146 1.000 rs7686186 chr4:6986094 C/T cg07817883 chr1:32538562 TMEM39B 1.51 13.4 0.59 5.67e-33 Granulocyte percentage of myeloid white cells; CRC cis rs7847628 0.587 rs4837796 chr9:123610288 A/G cg14255062 chr9:123606675 PSMD5;LOC253039 -0.59 -9.95 -0.48 1.46e-20 Birth weight; CRC cis rs11190604 1.000 rs11190558 chr10:102209397 C/A cg16342193 chr10:102329863 NA -0.35 -5.83 -0.31 1.29e-8 Palmitoleic acid (16:1n-7) levels; CRC cis rs4665809 0.627 rs35461456 chr2:26482361 C/G cg26119090 chr2:26468346 HADHA;HADHB 1.06 15.53 0.65 3.62e-41 Gut microbiome composition (summer); CRC cis rs1552244 0.608 rs3732962 chr3:10048951 T/C cg18598329 chr3:10140678 FANCD2;C3orf24 -0.54 -7.67 -0.39 1.98e-13 Alzheimer's disease; CRC cis rs55702914 0.628 rs67657812 chr2:198387401 A/G cg10820045 chr2:198174542 NA 0.34 5.96 0.31 6.6e-9 Major depression and alcohol dependence; CRC cis rs1448094 0.511 rs1993807 chr12:86146833 A/G cg25456477 chr12:86230367 RASSF9 -0.36 -6.07 -0.32 3.43e-9 Major depressive disorder; CRC cis rs6694672 1.000 rs1412633 chr1:197027220 C/G cg13682187 chr1:196946512 CFHR5 0.49 7.59 0.39 3.24e-13 Asthma; CRC cis rs1801251 1.000 rs283469 chr2:233656997 G/T cg25237894 chr2:233734115 C2orf82 0.51 8.29 0.42 2.97e-15 Coronary artery disease; CRC cis rs17711722 0.510 rs11767457 chr7:65290615 C/T cg00343986 chr7:65444356 GUSB 0.42 5.74 0.3 2.19e-8 Calcium levels; CRC cis rs2976388 0.609 rs1560986 chr8:143789775 T/C cg20041105 chr8:143859282 LYNX1 0.44 7.93 0.4 3.35e-14 Urinary tract infection frequency; CRC cis rs9311474 0.597 rs6778735 chr3:52565100 T/C cg18099408 chr3:52552593 STAB1 -0.65 -12.98 -0.58 2.15e-31 Electroencephalogram traits; CRC cis rs7937682 0.710 rs674230 chr11:111437887 A/G cg19812747 chr11:111475976 SIK2 -0.53 -8.81 -0.44 7.59e-17 Primary sclerosing cholangitis; CRC cis rs4819052 0.851 rs13047104 chr21:46673562 T/G cg02159808 chr21:46707872 POFUT2;LOC642852 0.53 6.93 0.36 2.17e-11 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs9527 0.615 rs11191485 chr10:104729816 G/C cg04362960 chr10:104952993 NT5C2 0.6 8.52 0.43 5.95e-16 Arsenic metabolism; CRC cis rs6540556 0.608 rs2064148 chr1:209909385 C/T cg23920097 chr1:209922102 NA 0.48 5.99 0.31 5.59e-9 Red blood cell count; CRC trans rs116095464 0.867 rs10074958 chr5:230828 C/T cg00938859 chr5:1591904 SDHAP3 0.72 7.97 0.4 2.65e-14 Breast cancer; CRC cis rs11758351 0.866 rs77889957 chr6:26207435 A/G cg10723962 chr6:26240782 HIST1H4F -0.38 -6.33 -0.33 7.95e-10 Gout;Renal underexcretion gout; CRC cis rs6860806 0.661 rs2136187 chr5:131577894 T/C cg27615366 chr5:131592974 PDLIM4 0.29 5.63 0.3 3.84e-8 Breast cancer; CRC cis rs8060686 0.641 rs7190079 chr16:68073834 G/A cg08314208 chr16:67682810 RLTPR -0.64 -6.74 -0.35 6.97e-11 HDL cholesterol;Metabolic syndrome; CRC cis rs4478858 0.684 rs3753374 chr1:31740668 C/T cg00250761 chr1:31883323 NA -0.4 -7.65 -0.39 2.23e-13 Alcohol dependence; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg10471644 chr12:6976491 TPI1 0.4 6.15 0.32 2.25e-9 Intelligence (multi-trait analysis); CRC cis rs9527 0.571 rs10786715 chr10:104620735 G/C cg04362960 chr10:104952993 NT5C2 0.56 7.9 0.4 4.29e-14 Arsenic metabolism; CRC cis rs4728302 0.869 rs6467510 chr7:133607968 A/G cg10665199 chr7:133106180 EXOC4 0.38 5.76 0.3 1.97e-8 Intelligence;Intelligence (multi-trait analysis); CRC trans rs8073060 0.660 rs34184070 chr17:34003810 A/G cg19694781 chr19:47549865 TMEM160 -1.07 -14.34 -0.62 1.5e-36 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; CRC cis rs6694672 0.764 rs6669113 chr1:197143279 A/C cg13682187 chr1:196946512 CFHR5 0.46 7.25 0.37 3.09e-12 Asthma; CRC trans rs561341 0.882 rs563539 chr17:30307958 A/G cg20587970 chr11:113659929 NA -1.16 -16.92 -0.68 1.22e-46 Hip circumference adjusted for BMI; CRC cis rs2576037 0.583 rs11659693 chr18:44458733 C/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.62 11.0 0.52 3.53e-24 Personality dimensions; CRC cis rs1153858 1.000 rs16952714 chr15:45650358 G/A cg14582100 chr15:45693742 SPATA5L1 0.28 5.94 0.31 7.23e-9 Homoarginine levels; CRC cis rs728616 0.867 rs17606361 chr10:81845411 G/C cg11900509 chr10:81946545 ANXA11 -0.56 -5.83 -0.31 1.3e-8 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs9469890 0.591 rs11754773 chr6:34577257 A/G cg14254433 chr6:34482411 PACSIN1 -0.73 -6.49 -0.34 3.14e-10 Pubertal anthropometrics;Coronary artery disease; CRC trans rs34421088 0.560 rs2618434 chr8:11398865 A/G cg06636001 chr8:8085503 FLJ10661 -0.53 -7.88 -0.4 4.83e-14 Neuroticism; CRC cis rs2153535 0.580 rs2143357 chr6:8497196 A/G cg21535247 chr6:8435926 SLC35B3 0.48 7.17 0.37 5.1e-12 Motion sickness; CRC trans rs66573146 0.572 rs67252699 chr4:6946411 A/G cg07817883 chr1:32538562 TMEM39B 1.1 11.79 0.54 5.31e-27 Granulocyte percentage of myeloid white cells; CRC cis rs8062405 0.965 rs62037363 chr16:28865042 T/C cg08761264 chr16:28874980 SH2B1 -0.44 -5.84 -0.31 1.27e-8 Cognitive ability (multi-trait analysis);Cognitive ability; CRC trans rs1814175 0.817 rs4881648 chr11:49812901 A/G cg11707556 chr5:10655725 ANKRD33B -0.43 -8.04 -0.41 1.65e-14 Height; CRC cis rs600231 0.542 rs10896010 chr11:65246220 C/A cg17120908 chr11:65337727 SSSCA1 -0.68 -7.56 -0.38 4.09e-13 Bone mineral density; CRC cis rs10791323 0.604 rs2723615 chr11:133704567 C/T cg15485101 chr11:133734466 NA 0.42 7.16 0.37 5.36e-12 Childhood ear infection; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg00859112 chr14:99736559 BCL11B 0.43 6.29 0.33 1.01e-9 Response to antipsychotic treatment; CRC cis rs2153535 0.580 rs2152348 chr6:8474301 C/A cg21535247 chr6:8435926 SLC35B3 0.5 7.56 0.38 4.18e-13 Motion sickness; CRC cis rs4727027 0.704 rs1123992 chr7:148907201 C/G cg23583168 chr7:148888333 NA -0.8 -13.28 -0.59 1.64e-32 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC cis rs11212617 0.967 rs396552 chr11:108221483 G/C cg01991180 chr11:108092276 ATM;NPAT 0.42 5.97 0.31 6.15e-9 Response to metformin in type 2 diabetes (glycemic); CRC cis rs7215564 0.908 rs35103651 chr17:78666732 T/C cg09596252 chr17:78655493 RPTOR 0.57 6.16 0.32 2.08e-9 Myopia (pathological); CRC cis rs6681460 1.000 rs6670378 chr1:67126585 C/T cg02459107 chr1:67143332 SGIP1 0.47 8.26 0.41 3.48e-15 Presence of antiphospholipid antibodies; CRC cis rs9649465 0.967 rs2402666 chr7:123285478 A/T cg03229431 chr7:123269106 ASB15 -0.4 -6.1 -0.32 2.97e-9 Migraine; CRC cis rs9533799 0.559 rs9533796 chr13:44790446 C/G cg19190762 chr13:44806055 NA 0.43 5.74 0.3 2.1e-8 Amyotrophic lateral sclerosis; CRC trans rs2018683 0.691 rs4722881 chr7:29001560 A/G cg19402173 chr7:128379420 CALU 0.5 7.28 0.37 2.48e-12 Response to irinotecan and platinum-based chemotherapy in non-small-cell lung cancer; CRC cis rs7666738 0.791 rs13149968 chr4:99070262 G/T cg17366294 chr4:99064904 C4orf37 0.43 7.29 0.37 2.29e-12 Colonoscopy-negative controls vs population controls; CRC cis rs4660306 0.961 rs12145526 chr1:45969036 G/C cg03123370 chr1:45965343 CCDC163P;MMACHC -0.56 -7.96 -0.4 2.9e-14 Homocysteine levels; CRC cis rs7586879 0.828 rs13387053 chr2:25103025 G/A cg22495460 chr2:25135724 ADCY3 -0.88 -15.15 -0.64 1.04e-39 Body mass index; CRC cis rs1580019 0.523 rs13236410 chr7:32690663 G/A cg06627557 chr7:32535165 LSM5;AVL9 0.94 17.01 0.68 5.56e-47 Cognitive ability; CRC cis rs6952808 0.724 rs7792631 chr7:1982779 C/T cg02951883 chr7:2050386 MAD1L1 -0.71 -10.7 -0.51 3.88e-23 Bipolar disorder and schizophrenia; CRC cis rs1707322 1.000 rs1768807 chr1:46510570 A/G cg03146154 chr1:46216737 IPP -0.53 -7.37 -0.38 1.42e-12 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs8180040 0.966 rs11710322 chr3:47331136 C/T cg02527881 chr3:46936655 PTH1R 0.41 7.28 0.37 2.45e-12 Colorectal cancer; CRC cis rs17270561 0.608 rs9358875 chr6:25738008 G/A cg17691542 chr6:26056736 HIST1H1C 0.73 9.28 0.46 2.3e-18 Iron status biomarkers; CRC cis rs4423214 1.000 rs12806844 chr11:71170770 G/A cg05163923 chr11:71159392 DHCR7 0.66 9.28 0.46 2.32e-18 Vitamin D levels; CRC cis rs10779751 1.000 rs1135172 chr1:11301714 C/T cg08854313 chr1:11322531 MTOR -0.66 -9.01 -0.44 1.73e-17 Body mass index; CRC trans rs6956675 0.915 rs7786464 chr7:62615322 C/A cg01314568 chr7:57830625 NA -0.68 -9.2 -0.45 4.16e-18 Obesity-related traits; CRC cis rs4285028 0.948 rs13089878 chr3:121703895 T/C cg20356878 chr3:121714668 ILDR1 -0.48 -6.98 -0.36 1.63e-11 Multiple sclerosis; CRC cis rs9467711 0.651 rs13192713 chr6:25943234 C/A cg08501292 chr6:25962987 TRIM38 1.12 10.69 0.51 4.27e-23 Autism spectrum disorder or schizophrenia; CRC cis rs6496667 0.738 rs62020723 chr15:90971738 G/C cg04176472 chr15:90893244 GABARAPL3 0.6 8.33 0.42 2.21e-15 Rheumatoid arthritis; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg20166106 chr17:78120787 EIF4A3 0.46 6.47 0.34 3.51e-10 Anxiety disorder; CRC cis rs1401999 1.000 rs6800217 chr3:183685893 T/C cg01324343 chr3:183735012 ABCC5 0.79 14.28 0.62 2.55e-36 Anterior chamber depth; CRC cis rs11628318 0.853 rs10151896 chr14:103039936 G/C cg08075719 chr14:103021372 NA -0.7 -9.58 -0.47 2.53e-19 Platelet count; CRC cis rs12701220 0.655 rs9638973 chr7:1133678 A/G cg26240231 chr7:1148101 C7orf50 -0.41 -5.92 -0.31 8.1e-9 Bronchopulmonary dysplasia; CRC cis rs1862618 0.853 rs1862619 chr5:56098256 T/A cg18230493 chr5:56204884 C5orf35 -0.7 -9.11 -0.45 8.53e-18 Initial pursuit acceleration; CRC cis rs6540556 0.769 rs7521461 chr1:209926207 C/G cg23920097 chr1:209922102 NA -0.53 -6.53 -0.34 2.51e-10 Red blood cell count; CRC cis rs704795 0.805 rs1728926 chr2:27612937 A/G cg27432699 chr2:27873401 GPN1 -0.5 -7.56 -0.38 3.99e-13 Menopause (age at onset); CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg23068124 chr14:58711505 PSMA3 0.5 6.48 0.34 3.34e-10 Thyroid stimulating hormone; CRC cis rs7089973 0.966 rs12775180 chr10:116639754 T/C cg23260525 chr10:116636907 FAM160B1 0.32 6.29 0.33 1.01e-9 Bipolar disorder or attention deficit hyperactivity disorder; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg01174859 chr7:128379317 CALU 0.41 6.61 0.34 1.54e-10 Liver disease severity in Alagille syndrome; CRC cis rs10256972 0.567 rs2949185 chr7:1209013 A/G cg23708337 chr7:1209742 NA 0.51 7.78 0.39 9.18e-14 Longevity;Endometriosis; CRC cis rs1451375 1.000 rs1451375 chr7:50622712 A/C cg18232548 chr7:50535776 DDC -0.46 -6.62 -0.34 1.43e-10 Malaria; CRC cis rs9487051 0.872 rs9372211 chr6:109609648 C/T cg01475377 chr6:109611718 NA -0.49 -9.26 -0.45 2.75e-18 Reticulocyte fraction of red cells; CRC cis rs9325144 0.560 rs11182952 chr12:38636278 C/A cg13010199 chr12:38710504 ALG10B -0.42 -6.0 -0.31 5.06e-9 Morning vs. evening chronotype; CRC cis rs8005677 1.000 rs4982709 chr14:23394699 C/T cg25600027 chr14:23388339 RBM23 -0.52 -8.06 -0.41 1.47e-14 Cognitive ability (multi-trait analysis); CRC cis rs7412746 0.611 rs4970931 chr1:150910727 G/A cg15448220 chr1:150897856 SETDB1 0.46 6.84 0.35 3.98e-11 Melanoma; CRC cis rs8177253 0.507 rs4241357 chr3:133475563 A/C cg17775713 chr3:133465469 TF -0.37 -6.92 -0.36 2.42e-11 Iron status biomarkers; CRC cis rs6694672 0.850 rs3891964 chr1:197066074 C/T cg13682187 chr1:196946512 CFHR5 -0.43 -6.87 -0.35 3.31e-11 Asthma; CRC cis rs950027 0.620 rs1145093 chr15:45649813 C/A cg21132104 chr15:45694354 SPATA5L1 0.42 6.1 0.32 2.96e-9 Response to fenofibrate (adiponectin levels); CRC cis rs3812762 0.871 rs11042068 chr11:8815599 C/G cg21881798 chr11:8931708 C11orf17;ST5 -0.41 -6.07 -0.32 3.57e-9 Hypospadias; CRC cis rs7044106 0.791 rs7036196 chr9:123479457 A/G cg09419670 chr9:123605666 PSMD5;LOC253039 0.75 12.1 0.56 3.85e-28 Hip circumference adjusted for BMI; CRC trans rs10506458 1.000 rs12425932 chr12:63410497 C/A cg03429785 chr15:59498649 MYO1E;LDHAL6B -1.34 -19.44 -0.73 1.39e-56 Hemostatic factors and hematological phenotypes; CRC trans rs61931739 0.517 rs7960878 chr12:34055645 C/A cg26384229 chr12:38710491 ALG10B 0.53 6.77 0.35 5.85e-11 Morning vs. evening chronotype; CRC cis rs10752881 1.000 rs6424879 chr1:182986592 T/C ch.1.3577855R chr1:183094577 LAMC1 0.86 15.22 0.64 5.91e-40 Colorectal cancer; CRC cis rs3806843 0.864 rs2531343 chr5:140129346 A/G cg19875535 chr5:140030758 IK -0.53 -8.41 -0.42 1.22e-15 Depressive symptoms (multi-trait analysis); CRC cis rs4481887 0.790 rs10888364 chr1:248488387 T/G cg13385794 chr1:248469461 NA 0.4 7.1 0.36 7.96e-12 Common traits (Other); CRC cis rs3018066 0.867 rs7673101 chr4:107095505 T/C cg01869342 chr4:106983673 TBCK 0.37 5.7 0.3 2.6e-8 Cancer; CRC cis rs4319547 1.000 rs6489071 chr12:123025576 C/G cg23029597 chr12:123009494 RSRC2 -0.63 -8.2 -0.41 5.31e-15 Body mass index; CRC cis rs10504073 0.584 rs55795863 chr8:49898055 A/G cg00325661 chr8:49890786 NA 0.63 11.4 0.53 1.33e-25 Blood metabolite ratios; CRC cis rs11098499 0.739 rs4833612 chr4:120147596 A/C cg09307838 chr4:120376055 NA -0.53 -8.41 -0.42 1.23e-15 Corneal astigmatism; CRC cis rs9399137 0.507 rs11154791 chr6:135379148 A/G cg22676075 chr6:135203613 NA 0.57 8.41 0.42 1.29e-15 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; CRC cis rs9611565 0.694 rs202618 chr22:41822856 A/G cg03806693 chr22:41940476 POLR3H 1.1 13.46 0.6 3.24e-33 Vitiligo; CRC cis rs62458065 0.850 rs7785659 chr7:32461015 C/T cg20159608 chr7:32802032 NA -0.54 -6.64 -0.34 1.26e-10 Metabolite levels (HVA/MHPG ratio); CRC cis rs7223966 1.000 rs8075422 chr17:61804686 G/A cg23090583 chr17:61904693 PSMC5;FTSJ3 0.45 5.72 0.3 2.39e-8 Hip circumference adjusted for BMI;Body mass index; CRC cis rs6951245 0.938 rs117729148 chr7:1108531 G/A cg03188948 chr7:1209495 NA 0.65 6.85 0.35 3.68e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs2652834 1.000 rs68088462 chr15:63397617 T/C cg05507819 chr15:63340323 TPM1 0.46 5.89 0.31 9.7e-9 HDL cholesterol; CRC cis rs6951245 0.882 rs10256720 chr7:1210825 C/G cg03188948 chr7:1209495 NA 0.78 8.78 0.44 9.3e-17 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC trans rs7618501 0.521 rs952594 chr3:49908023 G/A cg21665057 chr3:196295764 WDR53;FBXO45 0.53 7.96 0.4 2.84e-14 Intelligence (multi-trait analysis); CRC cis rs10883723 0.810 rs2296582 chr10:104244139 G/T cg22532475 chr10:104410764 TRIM8 -0.36 -6.41 -0.33 4.96e-10 Allergic disease (asthma, hay fever or eczema); CRC trans rs2727020 0.576 rs11040223 chr11:49034633 G/T cg15704280 chr7:45808275 SEPT13 -0.53 -7.51 -0.38 5.47e-13 Coronary artery disease; CRC cis rs7998202 0.667 rs914018 chr13:113354819 A/G cg02820901 chr13:113351484 ATP11A 0.6 6.6 0.34 1.62e-10 Glycated hemoglobin levels; CRC cis rs3892630 0.529 rs35300319 chr19:33409948 G/A cg22980127 chr19:33182716 NUDT19 0.62 7.83 0.4 6.88e-14 Red blood cell traits; CRC cis rs6570726 0.764 rs366673 chr6:145814628 T/A cg13319975 chr6:146136371 FBXO30 -0.44 -6.64 -0.34 1.32e-10 Lobe attachment (rater-scored or self-reported); CRC cis rs172166 0.694 rs188105 chr6:28071393 C/T cg26587870 chr6:27730563 NA -0.37 -5.64 -0.3 3.62e-8 Cardiac Troponin-T levels; CRC cis rs1215050 0.740 rs783916 chr4:99026264 A/C cg05340658 chr4:99064831 C4orf37 -0.48 -7.27 -0.37 2.62e-12 Waist-to-hip ratio adjusted for body mass index; CRC cis rs6598955 0.617 rs11247895 chr1:26599542 G/A cg04990556 chr1:26633338 UBXN11 0.53 5.73 0.3 2.23e-8 Obesity-related traits; CRC cis rs10991814 0.920 rs78181783 chr9:94032205 C/T cg14446406 chr9:93919335 NA 0.55 5.95 0.31 7.05e-9 Neutrophil percentage of granulocytes; CRC cis rs703842 1.000 rs11172333 chr12:58170335 A/G cg00677455 chr12:58241039 CTDSP2 0.66 9.0 0.44 1.83e-17 Multiple sclerosis; CRC cis rs11123170 0.543 rs2863242 chr2:113989236 C/T cg21482265 chr2:113992762 PAX8;LOC440839;LOC654433 0.51 5.91 0.31 8.63e-9 Renal function-related traits (BUN); CRC cis rs7772486 0.686 rs1004752 chr6:146037822 G/A cg23711669 chr6:146136114 FBXO30 -0.65 -10.71 -0.51 3.69e-23 Lobe attachment (rater-scored or self-reported); CRC cis rs2274273 0.840 rs28568813 chr14:55794114 C/G cg23234261 chr14:55582407 NA -0.29 -5.78 -0.3 1.75e-8 Protein biomarker; CRC cis rs600231 0.577 rs12269965 chr11:65232087 C/T cg17120908 chr11:65337727 SSSCA1 -0.69 -7.61 -0.39 2.89e-13 Bone mineral density; CRC trans rs2303319 0.504 rs72877343 chr2:162607487 A/C cg13490827 chr1:46269305 MAST2 -0.69 -6.0 -0.31 5.24e-9 Cognitive function; CRC cis rs6988636 1.000 rs62521826 chr8:124186668 C/T cg27053337 chr8:124217698 FAM83A 0.45 6.84 0.35 3.77e-11 Urinary uromodulin levels; CRC cis rs10193935 0.792 rs13430031 chr2:42499968 C/T cg27598129 chr2:42591480 NA -0.67 -7.55 -0.38 4.36e-13 Colonoscopy-negative controls vs population controls; CRC cis rs35306767 0.715 rs12777801 chr10:1036285 T/A cg26597838 chr10:835615 NA 0.95 10.47 0.5 2.45e-22 Eosinophil percentage of granulocytes; CRC cis rs4076764 0.958 rs12022261 chr1:163398422 A/G cg24596788 chr1:163392923 NA -0.68 -10.9 -0.52 7.79e-24 Motion sickness; CRC cis rs1862618 0.756 rs9292125 chr5:56107200 C/T cg22800045 chr5:56110881 MAP3K1 0.53 5.85 0.31 1.17e-8 Initial pursuit acceleration; CRC cis rs11233250 0.502 rs12422030 chr11:82405529 A/G cg17391194 chr11:82401662 NA 0.42 6.34 0.33 7.61e-10 Glioblastoma;Glioma; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg19898230 chr1:37980216 MEAF6 0.45 6.35 0.33 7.03e-10 Anxiety disorder; CRC cis rs57994353 0.897 rs55824202 chr9:139357273 A/T cg13856295 chr9:139396418 NOTCH1 -0.43 -5.7 -0.3 2.6e-8 Eosinophil counts;Cutaneous squamous cell carcinoma; CRC cis rs10504229 0.728 rs17804774 chr8:58155950 G/T cg21724239 chr8:58056113 NA 0.64 8.46 0.42 8.61e-16 Developmental language disorder (linguistic errors); CRC cis rs6951245 1.000 rs79422648 chr7:1080241 T/C cg20603222 chr7:1096387 C7orf50;GPR146 -0.68 -7.91 -0.4 4e-14 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs798554 0.680 rs2533889 chr7:2900309 G/C cg04166393 chr7:2884313 GNA12 0.5 6.59 0.34 1.73e-10 Height; CRC cis rs1008375 1.000 rs11727312 chr4:17669185 C/T cg16339924 chr4:17578868 LAP3 0.49 6.51 0.34 2.82e-10 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs4594175 0.926 rs10149006 chr14:51615265 A/C cg23942311 chr14:51606299 NA 0.65 10.48 0.5 2.33e-22 Cancer; CRC cis rs7615952 0.641 rs6438951 chr3:125696999 A/G cg05084668 chr3:125655381 ALG1L -0.47 -6.92 -0.36 2.41e-11 Blood pressure (smoking interaction); CRC trans rs7615952 0.800 rs11915699 chr3:125632684 A/G cg16558177 chr4:4109446 NA -0.49 -5.97 -0.31 6.09e-9 Blood pressure (smoking interaction); CRC cis rs7591163 1.000 rs7574255 chr2:228699884 C/G cg14329157 chr2:228736135 WDR69 0.46 6.31 0.33 9.17e-10 Blood pressure; CRC cis rs826838 0.935 rs1684406 chr12:39127265 A/G cg26384229 chr12:38710491 ALG10B -0.64 -9.58 -0.47 2.56e-19 Heart rate; CRC cis rs920590 0.684 rs57837509 chr8:19670088 A/G cg03894339 chr8:19674705 INTS10 0.41 5.75 0.3 2e-8 Acute lymphoblastic leukemia (childhood); CRC trans rs9388451 0.513 rs1268069 chr6:126039994 A/C cg05039488 chr6:79577232 IRAK1BP1 -0.65 -10.28 -0.49 1.12e-21 Brugada syndrome; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg09920427 chr19:12777674 MORG1;MAN2B1 0.54 7.85 0.4 5.84e-14 Response to antipsychotic treatment; CRC cis rs10178094 0.669 rs7595982 chr2:161332385 T/G cg03641300 chr2:160917029 PLA2R1 -0.44 -6.07 -0.32 3.61e-9 White blood cell count; CRC cis rs3806843 1.000 rs4451093 chr5:140158542 A/G cg19875535 chr5:140030758 IK -0.58 -9.4 -0.46 9.51e-19 Depressive symptoms (multi-trait analysis); CRC cis rs7917772 0.582 rs7907760 chr10:104345197 C/T cg11453585 chr10:104263688 ACTR1A;SUFU 0.82 15.29 0.64 3.08e-40 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC cis rs6951245 0.935 rs76525951 chr7:1096013 C/T cg20603222 chr7:1096387 C7orf50;GPR146 -0.72 -8.67 -0.43 1.96e-16 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs66573146 1.000 rs7686168 chr4:6986057 C/A cg00086871 chr4:6988644 TBC1D14 1.03 7.79 0.39 8.6e-14 Granulocyte percentage of myeloid white cells; CRC cis rs59918340 0.692 rs6983780 chr8:142231944 G/A cg03316587 chr8:142245164 NA -0.4 -6.04 -0.32 4.16e-9 Immature fraction of reticulocytes; CRC cis rs1163251 0.869 rs629735 chr1:120206932 G/T cg19096424 chr1:120255104 PHGDH -0.44 -6.19 -0.32 1.75e-9 Blood metabolite levels; CRC cis rs61160187 0.582 rs12652830 chr5:60252482 A/G cg16298547 chr5:60138761 ELOVL7 -0.27 -5.74 -0.3 2.13e-8 Educational attainment (years of education);Educational attainment (college completion); CRC cis rs875971 0.862 rs11765791 chr7:65936574 A/G cg00343986 chr7:65444356 GUSB 0.44 6.06 0.32 3.81e-9 Aortic root size; CRC cis rs7618915 0.621 rs6788993 chr3:52605136 T/C cg18099408 chr3:52552593 STAB1 -0.49 -8.35 -0.42 1.96e-15 Bipolar disorder; CRC cis rs11764590 0.671 rs62444906 chr7:2083161 G/T cg02421172 chr7:1938701 MAD1L1 0.46 6.11 0.32 2.83e-9 Neuroticism; CRC cis rs10256972 0.758 rs9801444 chr7:1080444 A/C cg18402987 chr7:1209562 NA -0.43 -6.4 -0.33 5.46e-10 Longevity;Endometriosis; CRC cis rs4731207 0.596 rs6957525 chr7:124656377 T/C cg23710748 chr7:124431027 NA -0.39 -6.25 -0.33 1.24e-9 Cutaneous malignant melanoma; CRC trans rs2303319 0.504 rs961421 chr2:162626099 G/C cg22627826 chr19:1240265 ATP5D -0.72 -6.24 -0.33 1.37e-9 Cognitive function; CRC cis rs763014 0.593 rs28455838 chr16:681966 T/C cg04497992 chr16:616212 NHLRC4 0.39 6.06 0.32 3.68e-9 Height; CRC cis rs1862618 0.853 rs33325 chr5:56142547 G/C cg18230493 chr5:56204884 C5orf35 -0.71 -9.11 -0.45 8.07e-18 Initial pursuit acceleration; CRC cis rs11148252 0.634 rs4941727 chr13:52721067 A/G cg12458913 chr13:53173898 NA -0.4 -6.0 -0.31 5.18e-9 Lewy body disease; CRC cis rs2404602 0.692 rs4886829 chr15:77091182 G/T cg22467129 chr15:76604101 ETFA -0.4 -6.59 -0.34 1.75e-10 Blood metabolite levels; CRC trans rs7267979 1.000 rs6083805 chr20:25317356 T/C cg17903999 chr18:56338584 MALT1 0.42 6.84 0.35 3.98e-11 Liver enzyme levels (alkaline phosphatase); CRC cis rs3736485 0.934 rs2414106 chr15:51868741 C/T cg08986416 chr15:51914746 DMXL2 -0.46 -6.63 -0.34 1.41e-10 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs7626444 0.625 rs2686599 chr3:196483794 G/A cg12930392 chr3:196481615 PAK2 0.39 7.11 0.36 7.25e-12 Monocyte count; CRC cis rs67311347 1.000 rs9874006 chr3:40471596 G/A cg09455208 chr3:40491958 NA 0.43 8.72 0.43 1.36e-16 Renal cell carcinoma; CRC cis rs7635838 0.684 rs2594965 chr3:11323799 G/C cg00170343 chr3:11313890 ATG7 0.44 6.62 0.34 1.5e-10 HDL cholesterol; CRC cis rs11690935 0.959 rs7604918 chr2:172588094 G/A cg13550731 chr2:172543902 DYNC1I2 -1.1 -18.53 -0.71 5.39e-53 Schizophrenia; CRC cis rs9814567 1.000 rs11919350 chr3:134235970 G/C cg06109529 chr3:134205091 CEP63;ANAPC13 0.82 12.09 0.55 4.21e-28 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC trans rs8108034 0.920 rs30480 chr19:39807213 A/G cg09325174 chr14:50154983 POLE2 -0.5 -6.0 -0.31 5.31e-9 Lung adenocarcinoma; CRC cis rs73200209 0.789 rs74420242 chr12:116551289 A/T cg01776926 chr12:116560359 MED13L -0.62 -7.27 -0.37 2.7e-12 Total body bone mineral density; CRC cis rs9303401 0.614 rs34058624 chr17:57118121 T/C cg02118635 chr17:56770003 RAD51C;TEX14 0.67 8.28 0.42 3.04e-15 Cognitive test performance; CRC cis rs3789045 0.560 rs1107339 chr1:204411942 C/T cg17419461 chr1:204415978 PIK3C2B -0.82 -10.9 -0.52 7.79e-24 Educational attainment (college completion); CRC cis rs875971 0.964 rs9691480 chr7:65944306 A/C cg11764359 chr7:65958608 NA 0.62 9.91 0.48 1.96e-20 Aortic root size; CRC cis rs9858542 1.000 rs1131095 chr3:49714225 T/C cg07274523 chr3:49395745 GPX1 0.47 5.98 0.31 5.79e-9 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg14868726 chr18:2571660 METTL4;NDC80 0.49 6.61 0.34 1.53e-10 Thyroid stimulating hormone; CRC cis rs9311474 0.596 rs524986 chr3:52228496 T/C cg15147215 chr3:52552868 STAB1 -0.44 -7.22 -0.37 3.7e-12 Electroencephalogram traits; CRC cis rs2573652 1.000 rs2581345 chr15:100514291 A/G cg00587665 chr15:100533223 ADAMTS17 -0.34 -5.86 -0.31 1.14e-8 Height; CRC cis rs9583531 0.657 rs7318291 chr13:111352460 C/T cg24331049 chr13:111365604 ING1 -0.64 -8.05 -0.41 1.53e-14 Coronary artery disease; CRC trans rs7395662 0.963 rs4882146 chr11:48660169 C/T cg21153622 chr11:89784906 NA -0.47 -7.6 -0.39 3.01e-13 HDL cholesterol; CRC cis rs13126513 0.510 rs10516445 chr4:100524679 C/G cg05468953 chr4:100565104 NA 0.52 8.25 0.41 3.78e-15 Metabolite levels (MHPG); CRC cis rs1005277 0.563 rs2800550 chr10:38482929 T/C cg00409905 chr10:38381863 ZNF37A -0.65 -10.65 -0.51 5.95e-23 Extrinsic epigenetic age acceleration; CRC cis rs4076764 0.846 rs7525724 chr1:163426372 G/A cg06092702 chr1:163392909 NA -0.54 -8.5 -0.42 6.64e-16 Motion sickness; CRC cis rs7412746 0.611 rs4970984 chr1:150887377 T/C cg15448220 chr1:150897856 SETDB1 0.46 6.84 0.35 3.98e-11 Melanoma; CRC cis rs6424115 1.000 rs6424115 chr1:24153231 A/G cg10978503 chr1:24200527 CNR2 -0.51 -8.85 -0.44 5.3e-17 Immature fraction of reticulocytes; CRC cis rs8067545 0.967 rs1034904 chr17:19927699 A/G cg13482628 chr17:19912719 NA -0.53 -8.52 -0.43 5.96e-16 Schizophrenia; CRC cis rs7659604 0.702 rs58649165 chr4:122693752 C/A cg20573242 chr4:122745356 CCNA2 0.51 7.41 0.38 1.07e-12 Type 2 diabetes; CRC cis rs6952808 0.609 rs6950151 chr7:1953521 T/C cg21782813 chr7:2030301 MAD1L1 0.39 7.29 0.37 2.33e-12 Bipolar disorder and schizophrenia; CRC cis rs9914988 0.887 rs4795464 chr17:27146497 G/C cg12682573 chr17:27188876 MIR451;MIR144 0.57 7.99 0.4 2.37e-14 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs72720396 0.789 rs12022460 chr1:91202257 A/G cg13456504 chr1:91191583 NA -0.48 -6.91 -0.36 2.47e-11 Morning vs. evening chronotype;Chronotype; CRC cis rs17095355 1.000 rs921351 chr10:111704715 A/G cg00817464 chr10:111662876 XPNPEP1 -0.6 -7.97 -0.4 2.62e-14 Biliary atresia; CRC cis rs9322193 0.923 rs9688861 chr6:149959060 G/T cg07701084 chr6:150067640 NUP43 0.54 7.96 0.4 2.81e-14 Lung cancer; CRC trans rs4714291 0.832 rs1524087 chr6:40057504 A/G cg02267698 chr19:7991119 CTXN1 -0.51 -7.04 -0.36 1.14e-11 Strep throat; CRC cis rs7843479 0.601 rs10453141 chr8:21847235 T/C cg17168535 chr8:21777572 XPO7 0.6 9.98 0.48 1.12e-20 Mean corpuscular volume; CRC cis rs9462846 0.658 rs9471970 chr6:42913646 G/A cg05552183 chr6:42928497 GNMT 0.47 6.57 0.34 1.92e-10 Blood protein levels; CRC trans rs9858542 0.953 rs6766581 chr3:49539401 T/C cg21665057 chr3:196295764 WDR53;FBXO45 -0.65 -8.86 -0.44 5.12e-17 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs754466 0.651 rs10824583 chr10:79619402 C/T cg17075019 chr10:79541650 NA 0.89 15.38 0.65 1.4e-40 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs2075371 0.527 rs1862046 chr7:134023524 T/C cg20476274 chr7:133979776 SLC35B4 0.54 7.7 0.39 1.63e-13 Mean platelet volume; CRC cis rs734999 0.545 rs4648356 chr1:2709164 C/A cg20673091 chr1:2541236 MMEL1 0.36 5.7 0.3 2.73e-8 Ulcerative colitis; CRC cis rs875971 1.000 rs6945843 chr7:65734783 G/A cg18876405 chr7:65276391 NA -0.51 -8.81 -0.44 7.46e-17 Aortic root size; CRC trans rs3942852 0.806 rs4752808 chr11:48141252 G/A cg15704280 chr7:45808275 SEPT13 -0.59 -7.47 -0.38 7.27e-13 Acute lymphoblastic leukemia (childhood); CRC cis rs4665809 0.652 rs10779956 chr2:26405985 A/G cg08067268 chr2:26466485 HADHB;HADHA -0.66 -8.31 -0.42 2.57e-15 Gut microbiome composition (summer); CRC cis rs1322512 1.000 rs2758782 chr6:153010341 C/T cg03415253 chr6:152958462 SYNE1 0.4 6.04 0.32 4.14e-9 Tonometry; CRC trans rs6550704 0.687 rs9865314 chr3:22634337 A/G cg24274428 chr6:13328569 TBC1D7 -0.44 -6.48 -0.34 3.28e-10 Daytime sleep phenotypes; CRC cis rs10504229 0.815 rs72650879 chr8:58164648 A/G cg20607798 chr8:58055168 NA 0.48 5.87 0.31 1.08e-8 Developmental language disorder (linguistic errors); CRC cis rs138857 0.515 rs9616375 chr22:50310600 G/A cg22709217 chr22:50311962 ALG12;CRELD2 -1.0 -10.2 -0.49 2.14e-21 Mean platelet volume; CRC cis rs995000 0.931 rs10889349 chr1:63081919 A/G cg19896129 chr1:63156450 NA 0.42 6.57 0.34 1.98e-10 Triglyceride levels; CRC cis rs7811142 0.943 rs111493473 chr7:100049742 A/G cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.06 15.5 0.65 4.65e-41 Platelet count; CRC cis rs2979489 0.891 rs3824107 chr8:30353412 A/G cg26383811 chr8:30366931 RBPMS 0.66 9.29 0.46 2.13e-18 Mean corpuscular hemoglobin;Plateletcrit;Neutrophil count;Granulocyte count;Sum basophil neutrophil counts;Mean corpuscular volume;Myeloid white cell count;Sum neutrophil eosinophil counts; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg07671174 chr3:58224051 ABHD6 0.52 6.78 0.35 5.62e-11 Anxiety disorder; CRC cis rs7786808 0.653 rs7810861 chr7:158212633 G/A cg15440763 chr7:158190612 PTPRN2 0.47 7.43 0.38 9.45e-13 Obesity-related traits; CRC cis rs1178968 1.000 rs757938 chr7:72778573 A/G cg25889504 chr7:72793014 NA 0.49 5.83 0.31 1.32e-8 Triglyceride levels; CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg11543725 chr11:10329292 NA 0.36 6.08 0.32 3.25e-9 Obesity-related traits; CRC cis rs2996428 0.667 rs11578581 chr1:3770642 G/A cg13057898 chr1:3703894 LRRC47 0.52 6.85 0.35 3.61e-11 Red cell distribution width; CRC cis rs12024301 0.557 rs61040652 chr1:183642153 C/T cg11505048 chr1:183622726 RGL1;APOBEC4 0.81 7.06 0.36 1.01e-11 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs11677416 1.000 rs1878319 chr2:113544826 G/A cg06156847 chr2:113672199 IL1F7 -0.4 -5.98 -0.31 5.91e-9 Response to antipsychotic treatment in schizophrenia (working memory); CRC cis rs7927771 1.000 rs34910028 chr11:47758449 T/C cg20307385 chr11:47447363 PSMC3 -0.5 -6.64 -0.34 1.29e-10 Subjective well-being; CRC cis rs244731 0.959 rs9313752 chr5:176645435 G/T cg16006841 chr5:176797999 RGS14 -0.65 -8.69 -0.43 1.71e-16 Urate levels in lean individuals; CRC cis rs7208859 0.573 rs28779471 chr17:29084369 T/C cg01831904 chr17:28903510 LRRC37B2 -0.63 -6.45 -0.33 4.07e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs2880765 0.835 rs6497206 chr15:86029225 A/G cg17133734 chr15:86042851 AKAP13 0.43 6.88 0.35 2.94e-11 Coronary artery disease; CRC cis rs9926296 0.618 rs8058179 chr16:89846987 C/T cg27121462 chr16:89883253 FANCA -0.4 -6.02 -0.31 4.72e-9 Vitiligo; CRC cis rs35110281 0.633 rs4818860 chr21:45119617 C/T cg01579765 chr21:45077557 HSF2BP -0.32 -6.06 -0.32 3.77e-9 Mean corpuscular volume; CRC cis rs9611565 0.765 rs132908 chr22:41801795 G/A cg06481639 chr22:41940642 POLR3H 0.52 5.82 0.31 1.4e-8 Vitiligo; CRC cis rs9807989 0.501 rs11903946 chr2:103005330 A/G cg03938978 chr2:103052716 IL18RAP 0.59 10.18 0.49 2.53e-21 Asthma; CRC cis rs8180040 0.627 rs6442059 chr3:47187075 C/G cg10298567 chr3:47292165 KIF9 -0.4 -6.25 -0.33 1.3e-9 Colorectal cancer; CRC cis rs755249 0.567 rs61783376 chr1:39769000 T/C cg18385671 chr1:39797026 MACF1 -0.42 -5.98 -0.31 5.94e-9 Peripheral arterial disease (traffic-related air pollution interaction); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg08393086 chr7:100081535 C7orf51 0.39 6.23 0.32 1.45e-9 Liver disease severity in Alagille syndrome; CRC cis rs11785693 0.862 rs11782343 chr8:5001642 C/G cg26367366 chr8:4980734 NA 0.49 6.22 0.32 1.49e-9 Neuroticism (multi-trait analysis);Neuroticism; CRC cis rs7662987 0.517 rs2602866 chr4:100034997 A/G cg13256891 chr4:100009986 ADH5 0.63 8.54 0.43 4.99e-16 Smoking initiation; CRC cis rs2046867 0.908 rs1106310 chr3:72818902 A/T cg25664220 chr3:72788482 NA 0.42 6.71 0.35 8.32e-11 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; CRC cis rs62064224 0.509 rs2302276 chr17:30791503 C/T cg12855166 chr17:30846586 MYO1D -0.37 -6.01 -0.31 4.87e-9 Schizophrenia; CRC trans rs6693295 0.729 rs10802325 chr1:246213454 C/A cg03680032 chr11:94965610 SESN3 0.53 6.57 0.34 2e-10 Migraine - clinic-based;Migraine with aura; CRC cis rs523522 0.962 rs4767914 chr12:120993817 C/T cg27279351 chr12:120934652 DYNLL1 0.77 11.24 0.53 4.96e-25 High light scatter reticulocyte count; CRC cis rs1003719 0.762 rs11088381 chr21:38478429 G/A cg10648535 chr21:38446584 PIGP;TTC3 0.52 7.27 0.37 2.6e-12 Eye color traits; CRC cis rs863345 0.604 rs10797012 chr1:158465485 C/T cg12129480 chr1:158549410 OR10X1 -0.29 -6.11 -0.32 2.86e-9 Pneumococcal bacteremia; CRC cis rs9322193 0.923 rs10747276 chr6:150079875 G/A cg05861140 chr6:150128134 PCMT1 -0.36 -5.76 -0.3 1.93e-8 Lung cancer; CRC cis rs10256972 0.681 rs12702016 chr7:1129392 C/T cg09177884 chr7:1199841 ZFAND2A -0.4 -5.72 -0.3 2.45e-8 Longevity;Endometriosis; CRC cis rs10911232 0.507 rs10911199 chr1:182998036 T/A ch.1.3577855R chr1:183094577 LAMC1 0.86 15.15 0.64 1.1e-39 Hypertriglyceridemia; CRC cis rs6502050 0.835 rs3924781 chr17:80113130 T/C cg25804541 chr17:80189381 SLC16A3 -0.32 -5.98 -0.31 5.67e-9 Life satisfaction; CRC cis rs11122272 0.735 rs2009873 chr1:231499236 C/T cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.53 -8.1 -0.41 1.12e-14 Hemoglobin concentration; CRC cis rs597539 0.616 rs72945243 chr11:68633358 T/C cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.87 15.45 0.65 7.14e-41 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs2396545 0.591 rs12802200 chr11:566936 C/A cg01842473 chr11:617407 IRF7;MUPCDH -0.51 -5.67 -0.3 3.11e-8 Systemic lupus erythematosus and Systemic sclerosis; CRC cis rs7474896 0.537 rs1208591 chr10:38212502 A/T cg25427524 chr10:38739819 LOC399744 -0.54 -6.65 -0.34 1.21e-10 Obesity (extreme); CRC cis rs7772486 0.632 rs9386128 chr6:146049053 G/A cg23711669 chr6:146136114 FBXO30 -0.64 -10.66 -0.51 5.7e-23 Lobe attachment (rater-scored or self-reported); CRC cis rs7703051 0.513 rs6895057 chr5:74624234 G/A cg00601450 chr5:74908170 NA -0.39 -5.61 -0.3 4.2e-8 LDL cholesterol;Age-related disease endophenotypes;Age-related diseases, mortality and associated endophenotypes; CRC cis rs12980942 0.591 rs2304232 chr19:41762525 A/G cg25627403 chr19:41769009 HNRNPUL1 0.57 6.59 0.34 1.78e-10 Coronary artery disease; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg16266895 chr12:101674004 UTP20 0.44 6.23 0.32 1.44e-9 Response to antipsychotic treatment; CRC cis rs3740540 0.507 rs897293 chr10:126290050 T/G cg04949429 chr10:126290192 LHPP 0.43 6.37 0.33 6.44e-10 Obesity-related traits;Acute lymphoblastic leukemia (childhood); CRC cis rs897984 0.542 rs4468641 chr16:31096876 A/C cg00531865 chr16:30841666 NA -0.44 -6.36 -0.33 6.82e-10 Dementia with Lewy bodies; CRC cis rs10504229 0.774 rs72650880 chr8:58164727 C/T cg02725872 chr8:58115012 NA -0.54 -7.8 -0.4 8.17e-14 Developmental language disorder (linguistic errors); CRC cis rs16975963 0.843 rs73041047 chr19:38299289 T/C cg15135657 chr19:38346511 NA -0.45 -5.91 -0.31 8.61e-9 Longevity; CRC cis rs1862618 0.853 rs2432195 chr5:56120413 C/T cg24531977 chr5:56204891 C5orf35 -0.79 -10.66 -0.51 5.31e-23 Initial pursuit acceleration; CRC trans rs9329221 0.683 rs4598253 chr8:9890304 A/T cg16141378 chr3:129829833 LOC729375 0.43 6.7 0.35 8.97e-11 Neuroticism; CRC cis rs16867335 0.652 rs1528439 chr2:181462035 C/T cg23363182 chr2:181467187 NA -0.52 -8.37 -0.42 1.64e-15 Survival in rectal cancer; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg16118817 chr19:4792497 FEM1A 0.33 5.99 0.31 5.55e-9 Liver disease severity in Alagille syndrome; CRC cis rs4843747 0.636 rs11117358 chr16:88105053 T/A cg07865391 chr16:88106882 BANP 0.45 5.95 0.31 6.92e-9 Menopause (age at onset); CRC cis rs274567 0.501 rs274571 chr5:131712125 A/G cg20512303 chr5:131592959 PDLIM4 -0.39 -6.82 -0.35 4.49e-11 Blood metabolite levels; CRC cis rs10463316 0.894 rs6579866 chr5:150762524 A/G cg03212797 chr5:150827313 SLC36A1 -0.5 -7.78 -0.39 9.41e-14 Metabolite levels (Pyroglutamine); CRC trans rs9929218 0.551 rs2296409 chr16:68713730 G/A cg04657470 chr2:198365150 HSPE1;HSPD1 1.21 31.22 0.86 2.14e-100 Colorectal cancer; CRC cis rs9660180 0.967 rs12034740 chr1:1728969 C/A cg17747265 chr1:1875780 NA -0.73 -12.7 -0.57 2.45e-30 Body mass index; CRC cis rs13108904 0.557 rs1680030 chr4:1245500 A/T cg19318889 chr4:1322082 MAEA -0.65 -9.34 -0.46 1.55e-18 Obesity-related traits; CRC cis rs1577917 0.958 rs12209668 chr6:86566517 C/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.51 -6.59 -0.34 1.76e-10 Response to antipsychotic treatment; CRC cis rs9733 0.526 rs6587542 chr1:150907701 G/T cg15448220 chr1:150897856 SETDB1 0.46 6.84 0.35 3.98e-11 Tonsillectomy; CRC cis rs11030122 0.632 rs7925954 chr11:3982746 A/T cg18678763 chr11:4115507 RRM1 -0.41 -6.89 -0.35 2.92e-11 Mean platelet volume;Platelet distribution width; CRC cis rs4474465 0.688 rs10751296 chr11:78277277 C/T cg27205649 chr11:78285834 NARS2 -0.55 -7.14 -0.37 5.91e-12 Alzheimer's disease (survival time); CRC cis rs2408955 0.521 rs10875749 chr12:48531917 T/A cg21466736 chr12:48725269 NA 0.47 7.15 0.37 5.57e-12 Glycated hemoglobin levels; CRC cis rs7107174 0.901 rs2450138 chr11:77924870 C/T cg02023728 chr11:77925099 USP35 0.51 7.72 0.39 1.4e-13 Testicular germ cell tumor; CRC trans rs6601327 0.613 rs11785458 chr8:9506810 T/C cg06636001 chr8:8085503 FLJ10661 -0.47 -6.94 -0.36 2.07e-11 Multiple myeloma (hyperdiploidy); CRC trans rs951252 0.504 rs11734405 chr4:146081096 C/T cg26534993 chr2:3291401 TSSC1 -0.47 -6.19 -0.32 1.83e-9 Hip circumference; CRC cis rs2692947 0.770 rs6719831 chr2:96502590 A/C cg23100626 chr2:96804247 ASTL 0.27 7.07 0.36 9.2e-12 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; CRC cis rs514406 0.679 rs499239 chr1:53310594 A/G cg25767906 chr1:53392781 SCP2 -0.53 -8.39 -0.42 1.5e-15 Monocyte count; CRC trans rs8089364 0.917 rs35476226 chr18:57885593 C/G cg05871254 chr17:14213225 HS3ST3B1 -0.45 -6.45 -0.34 4.07e-10 Type 2 diabetes;Body mass index; CRC cis rs16852403 0.517 rs7531227 chr1:178232469 C/T cg00404053 chr1:178313656 RASAL2 0.49 6.18 0.32 1.88e-9 Childhood ear infection; CRC cis rs1448094 0.512 rs12309296 chr12:86241566 T/C cg25456477 chr12:86230367 RASSF9 0.32 5.67 0.3 3.13e-8 Major depressive disorder; CRC cis rs2204008 0.807 rs12816136 chr12:38456037 A/G cg13010199 chr12:38710504 ALG10B -0.48 -6.83 -0.35 4.18e-11 Bladder cancer; CRC cis rs11864453 0.713 rs7191127 chr16:72123992 G/T cg23815491 chr16:72088622 HP 0.5 7.6 0.39 3.09e-13 Fibrinogen levels; CRC cis rs9400239 0.584 rs1268179 chr6:109017237 G/C cg11073813 chr6:109029018 NA -0.38 -5.84 -0.31 1.23e-8 Waist circumference;Body mass index;BMI (adjusted for smoking behaviour); CRC cis rs4363385 0.620 rs4388644 chr1:152983674 A/G cg25856811 chr1:152973957 SPRR3 -0.25 -6.75 -0.35 6.61e-11 Inflammatory skin disease; CRC cis rs6860806 1.000 rs6860806 chr5:131640536 C/T cg04518342 chr5:131593106 PDLIM4 -0.36 -6.53 -0.34 2.54e-10 Breast cancer; CRC cis rs11122272 0.735 rs2486736 chr1:231521478 A/G cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX 0.51 7.43 0.38 9.24e-13 Hemoglobin concentration; CRC cis rs3806843 0.576 rs246021 chr5:140334504 C/A cg19875535 chr5:140030758 IK 0.4 6.12 0.32 2.64e-9 Depressive symptoms (multi-trait analysis); CRC trans rs17685 0.816 rs11763076 chr7:75765963 C/T cg19862616 chr7:65841803 NCRNA00174 0.99 18.11 0.71 2.51e-51 Coffee consumption;Coffee consumption (cups per day); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg21215323 chr15:41220556 DLL4 0.52 7.63 0.39 2.57e-13 Response to antipsychotic treatment; CRC cis rs739401 0.967 rs451041 chr11:3060725 C/T cg05729581 chr11:3078854 CARS -0.4 -5.72 -0.3 2.44e-8 Longevity; CRC cis rs7542091 0.669 rs11119357 chr1:210042382 C/T cg22029157 chr1:209979665 IRF6 0.48 7.41 0.38 1.05e-12 Monobrow; CRC cis rs6815814 0.950 rs11722788 chr4:38810738 C/G cg06935464 chr4:38784597 TLR10 0.55 5.66 0.3 3.27e-8 Breast cancer; CRC trans rs11098499 0.909 rs11723757 chr4:120299669 C/T cg25214090 chr10:38739885 LOC399744 0.63 9.8 0.48 4.51e-20 Corneal astigmatism; CRC cis rs968567 0.817 rs61896141 chr11:61556039 A/C cg05698098 chr11:61595494 FADS2 -0.42 -5.73 -0.3 2.3e-8 Blood metabolite levels;Rheumatoid arthritis;Vitiligo;Glycerophospholipid levels; CRC cis rs892961 0.867 rs6501955 chr17:75414443 A/G cg05865280 chr17:75406074 SEPT9 0.62 14.01 0.61 2.8e-35 Airflow obstruction; CRC cis rs4713118 0.513 rs149950 chr6:28033039 T/G cg06470822 chr6:28175283 NA 0.8 12.0 0.55 9.26e-28 Parkinson's disease; CRC cis rs4474465 0.790 rs4492845 chr11:78260161 C/T cg02023728 chr11:77925099 USP35 -0.36 -6.07 -0.32 3.53e-9 Alzheimer's disease (survival time); CRC cis rs1983891 0.955 rs4714479 chr6:41518807 A/G cg20194872 chr6:41519635 FOXP4 0.4 5.89 0.31 9.33e-9 Prostate cancer; CRC cis rs12681287 0.546 rs12546802 chr8:87499335 T/A cg27223183 chr8:87520930 FAM82B -0.53 -7.64 -0.39 2.46e-13 Caudate activity during reward; CRC cis rs10504229 1.000 rs74546828 chr8:58171678 A/G cg02290350 chr8:58132656 NA -0.42 -5.96 -0.31 6.62e-9 Developmental language disorder (linguistic errors); CRC cis rs17376456 0.569 rs10476520 chr5:93058290 A/C cg25358565 chr5:93447407 FAM172A 0.7 8.37 0.42 1.65e-15 Diabetic retinopathy; CRC cis rs11628318 0.614 rs7155489 chr14:103123119 C/T cg23461800 chr14:103021989 NA 0.64 6.94 0.36 2.11e-11 Platelet count; CRC cis rs10927875 0.894 rs34957618 chr1:16320499 G/C cg21385522 chr1:16154831 NA -0.6 -7.72 -0.39 1.43e-13 Dilated cardiomyopathy; CRC cis rs7737355 0.645 rs184950 chr5:130852847 G/A cg06307176 chr5:131281290 NA 0.43 6.28 0.33 1.05e-9 Life satisfaction; CRC cis rs9300255 0.510 rs1727322 chr12:123699520 A/G cg00376283 chr12:123451042 ABCB9 0.59 6.83 0.35 4.23e-11 Neutrophil percentage of white cells; CRC cis rs13108904 0.901 rs7668661 chr4:1300172 A/G cg02018176 chr4:1364513 KIAA1530 0.39 6.56 0.34 2.07e-10 Obesity-related traits; CRC cis rs34172651 0.517 rs11642954 chr16:24824248 G/A cg02428538 chr16:24856791 SLC5A11 -0.54 -6.3 -0.33 9.54e-10 Intelligence (multi-trait analysis); CRC cis rs9322193 0.884 rs9480009 chr6:150079638 A/G cg00933542 chr6:150070202 PCMT1 0.33 6.97 0.36 1.73e-11 Lung cancer; CRC trans rs7647973 0.588 rs4855848 chr3:49653457 C/T cg21665057 chr3:196295764 WDR53;FBXO45 -0.67 -7.37 -0.38 1.43e-12 Menarche (age at onset); CRC cis rs68170813 0.527 rs78133594 chr7:107025260 T/C cg02696742 chr7:106810147 HBP1 -0.52 -5.76 -0.3 1.98e-8 Coronary artery disease; CRC cis rs1862618 0.853 rs252898 chr5:56188931 T/C cg22800045 chr5:56110881 MAP3K1 0.6 6.38 0.33 5.99e-10 Initial pursuit acceleration; CRC cis rs17253792 0.822 rs10148983 chr14:56051879 A/G cg24579896 chr14:56047964 C14orf33;KTN1 0.72 6.11 0.32 2.88e-9 Putamen volume; CRC cis rs10256972 0.577 rs6962809 chr7:1208889 A/G cg26608667 chr7:1196370 ZFAND2A 0.44 7.16 0.37 5.41e-12 Longevity;Endometriosis; CRC cis rs734999 0.572 rs2985857 chr1:2532624 C/T cg20673091 chr1:2541236 MMEL1 -0.36 -5.78 -0.3 1.76e-8 Ulcerative colitis; CRC cis rs9303280 0.806 rs12941333 chr17:38040534 C/T cg17467752 chr17:38218738 THRA -0.37 -5.65 -0.3 3.39e-8 Self-reported allergy; CRC cis rs2032447 0.765 rs6942072 chr6:26014987 A/G cg03264133 chr6:25882463 NA -0.47 -6.5 -0.34 2.99e-10 Intelligence (multi-trait analysis); CRC cis rs12477438 0.798 rs12473029 chr2:99637961 A/G cg14399236 chr2:99771627 LIPT1;TSGA10 -0.75 -10.56 -0.5 1.22e-22 Chronic sinus infection; CRC cis rs3820068 0.532 rs72645862 chr1:15920366 A/G cg13390004 chr1:15929781 NA 0.5 6.88 0.35 3.01e-11 Systolic blood pressure; CRC cis rs7726839 0.540 rs57306627 chr5:597643 T/C cg14541582 chr5:601475 NA -0.35 -7.25 -0.37 3.02e-12 Obesity-related traits; CRC cis rs6951245 0.572 rs112072378 chr7:1039400 C/T cg26224354 chr7:1096374 C7orf50;GPR146 -0.97 -8.25 -0.41 3.81e-15 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC trans rs2727020 0.636 rs11040368 chr11:49453602 C/A cg21153622 chr11:89784906 NA -0.37 -6.0 -0.31 5.06e-9 Coronary artery disease; CRC trans rs703108 0.731 rs7898954 chr10:22323646 A/G cg07506689 chr16:72459978 NA 0.48 6.0 0.31 5.07e-9 Monocyte percentage of white cells; CRC cis rs10504229 0.683 rs56211106 chr8:58113497 A/G cg24829409 chr8:58192753 C8orf71 -0.54 -7.88 -0.4 4.9e-14 Developmental language disorder (linguistic errors); CRC cis rs7095944 0.583 rs12218394 chr10:126480591 G/C cg08799069 chr10:126477246 METTL10 -0.46 -7.21 -0.37 3.86e-12 Asthma; CRC cis rs9910055 0.821 rs4473241 chr17:42281282 G/T cg10896456 chr17:42255109 ASB16;C17orf65 0.46 8.02 0.4 1.87e-14 Total body bone mineral density; CRC cis rs1150668 0.796 rs213236 chr6:28324397 T/C cg03623178 chr6:28175578 NA 0.53 7.8 0.4 8.33e-14 Pubertal anthropometrics; CRC cis rs877282 1.000 rs12219807 chr10:772870 A/C cg06581033 chr10:766294 NA -0.48 -5.76 -0.3 1.94e-8 Uric acid levels; CRC cis rs72717009 0.825 rs6671753 chr1:161478708 G/A cg15358701 chr1:161410459 NA -0.62 -6.63 -0.34 1.39e-10 Rheumatoid arthritis; CRC cis rs9911578 1.000 rs11869828 chr17:56609525 G/A cg12560992 chr17:57184187 TRIM37 -0.91 -17.13 -0.69 1.81e-47 Intelligence (multi-trait analysis); CRC trans rs596169 0.541 rs73111535 chr1:219222850 C/A cg09853702 chr12:47665230 NA 0.82 6.36 0.33 6.59e-10 Intraocular pressure; CRC cis rs10256972 0.616 rs4585652 chr7:1145396 A/G cg23708337 chr7:1209742 NA 0.44 6.52 0.34 2.6e-10 Longevity;Endometriosis; CRC cis rs3008870 0.920 rs2755253 chr1:67470843 C/T cg21115004 chr1:67520352 SLC35D1 -0.4 -5.8 -0.3 1.54e-8 Lymphocyte percentage of white cells; CRC cis rs10504229 0.645 rs56670121 chr8:58138872 C/T cg22535103 chr8:58192502 C8orf71 -0.7 -9.31 -0.46 1.84e-18 Developmental language disorder (linguistic errors); CRC cis rs875971 0.737 rs7803424 chr7:65880605 T/C cg18912574 chr7:65842487 NCRNA00174 0.36 6.18 0.32 1.88e-9 Aortic root size; CRC cis rs10504229 0.683 rs77548248 chr8:58117542 G/A cg02725872 chr8:58115012 NA -0.65 -11.45 -0.53 8.72e-26 Developmental language disorder (linguistic errors); CRC cis rs11792861 0.781 rs72607158 chr9:111763010 T/C cg05043794 chr9:111880884 C9orf5 -0.33 -5.68 -0.3 2.96e-8 Menarche (age at onset); CRC cis rs4728302 0.869 rs7805864 chr7:133610390 G/A cg10665199 chr7:133106180 EXOC4 0.38 5.73 0.3 2.22e-8 Intelligence;Intelligence (multi-trait analysis); CRC cis rs968567 0.638 rs7943728 chr11:61547068 G/A cg05698098 chr11:61595494 FADS2 -0.42 -5.71 -0.3 2.52e-8 Blood metabolite levels;Rheumatoid arthritis;Vitiligo;Glycerophospholipid levels; CRC cis rs4148883 0.689 rs2851275 chr4:100024883 A/G cg12011299 chr4:100065546 ADH4 0.54 12.03 0.55 7.34e-28 Alcohol dependence; CRC cis rs9311676 0.609 rs62258133 chr3:58398318 C/G cg06643156 chr3:58380774 PXK 0.42 6.38 0.33 5.84e-10 Systemic lupus erythematosus; CRC trans rs61931739 0.517 rs1586409 chr12:34046614 C/A cg26384229 chr12:38710491 ALG10B 0.51 6.96 0.36 1.82e-11 Morning vs. evening chronotype; CRC cis rs11764590 0.543 rs55893771 chr7:2096255 C/T cg21155852 chr7:2048760 MAD1L1 -0.43 -5.74 -0.3 2.13e-8 Neuroticism; CRC cis rs9549367 0.789 rs6577031 chr13:113878182 T/C cg00898013 chr13:113819073 PROZ 0.42 6.26 0.33 1.2e-9 Platelet distribution width; CRC cis rs10504229 0.683 rs11786845 chr8:58133642 T/C cg02290350 chr8:58132656 NA -0.58 -8.21 -0.41 5e-15 Developmental language disorder (linguistic errors); CRC cis rs9400271 0.632 rs9384703 chr6:109586803 A/G cg01475377 chr6:109611718 NA -0.35 -5.94 -0.31 7.39e-9 Sum neutrophil eosinophil counts;Sum basophil neutrophil counts;White blood cell count;Neutrophil count;Myeloid white cell count;Granulocyte count; CRC cis rs2842992 0.714 rs2495278 chr6:160123674 G/A cg19482086 chr6:160211437 TCP1;MRPL18 0.7 8.6 0.43 3.35e-16 Age-related macular degeneration (geographic atrophy); CRC cis rs5750830 0.594 rs5757650 chr22:39778419 A/G cg24399712 chr22:39784796 NA -0.5 -9.42 -0.46 8.42e-19 Intelligence (multi-trait analysis); CRC cis rs1728785 0.901 rs1728797 chr16:68570989 A/T cg02972257 chr16:68554789 NA -0.58 -7.15 -0.37 5.78e-12 Ulcerative colitis; CRC cis rs2839186 0.588 rs2839140 chr21:47616080 G/A cg26721908 chr21:47610096 LSS 0.45 7.39 0.38 1.21e-12 Testicular germ cell tumor; CRC cis rs10504229 0.683 rs10504223 chr8:58140944 G/A cg02725872 chr8:58115012 NA -0.64 -11.55 -0.54 3.85e-26 Developmental language disorder (linguistic errors); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg00309650 chr4:88312547 HSD17B11 0.43 6.34 0.33 7.64e-10 Intelligence (multi-trait analysis); CRC cis rs4972806 0.668 rs2072588 chr2:177042930 G/C cg13092806 chr2:177043255 NA 0.8 12.86 0.58 5.95e-31 IgG glycosylation; CRC cis rs13108904 0.967 rs12502916 chr4:1276349 G/A cg20887711 chr4:1340912 KIAA1530 -0.45 -6.48 -0.34 3.37e-10 Obesity-related traits; CRC cis rs951366 0.622 rs11580015 chr1:205676088 G/C cg07167872 chr1:205819463 PM20D1 0.78 11.68 0.54 1.36e-26 Menarche (age at onset); CRC cis rs1865760 0.964 rs3799373 chr6:25929173 A/C cg16482183 chr6:26056742 HIST1H1C 0.53 7.57 0.39 3.86e-13 Height; CRC trans rs7647973 0.626 rs7637711 chr3:49829653 A/G cg21665057 chr3:196295764 WDR53;FBXO45 0.6 6.71 0.35 8.75e-11 Menarche (age at onset); CRC cis rs1218582 0.772 rs877343 chr1:154910012 A/G cg06221963 chr1:154839813 KCNN3 -0.75 -14.88 -0.63 1.21e-38 Prostate cancer; CRC cis rs1348850 0.668 rs2365619 chr2:178497366 A/G cg02961200 chr2:178257176 LOC100130691;AGPS -0.45 -5.74 -0.3 2.2e-8 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs7618915 0.524 rs2028216 chr3:52680823 C/T cg15147215 chr3:52552868 STAB1 -0.62 -10.31 -0.49 8.76e-22 Bipolar disorder; CRC cis rs919433 0.927 rs1429418 chr2:198158151 G/C cg03934865 chr2:198174659 NA -0.47 -7.33 -0.37 1.76e-12 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC cis rs2839186 0.609 rs2839189 chr21:47694357 C/T cg00612595 chr21:47717864 NA 0.41 6.62 0.34 1.44e-10 Testicular germ cell tumor; CRC cis rs3804749 0.966 rs3792378 chr3:122845077 G/A cg26084141 chr3:122786895 PDIA5 0.23 6.16 0.32 2.16e-9 Plateletcrit;Mean platelet volume;Platelet count;Platelet distribution width; CRC cis rs9487051 0.872 rs9487032 chr6:109605323 G/T cg01475377 chr6:109611718 NA -0.49 -9.22 -0.45 3.54e-18 Reticulocyte fraction of red cells; CRC cis rs7725052 0.609 rs7709690 chr5:40456871 G/A cg09067459 chr5:40385259 NA 0.39 6.43 0.33 4.42e-10 Pediatric autoimmune diseases; CRC trans rs1814175 0.645 rs847635 chr11:49923323 G/A cg15704280 chr7:45808275 SEPT13 -0.95 -16.82 -0.68 3.11e-46 Height; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg19564637 chr14:56584874 PELI2 0.43 6.05 0.32 3.92e-9 Response to antipsychotic treatment; CRC cis rs250677 0.617 rs166106 chr5:148447061 T/C cg18129178 chr5:148520854 ABLIM3 -0.39 -5.84 -0.31 1.27e-8 Breast cancer; CRC cis rs16924133 0.793 rs12292299 chr11:33132499 G/A cg05567920 chr11:33183001 CSTF3 -0.77 -5.8 -0.3 1.58e-8 Anger; CRC cis rs9916302 0.706 rs903507 chr17:37726423 A/G cg07936489 chr17:37558343 FBXL20 -0.95 -11.96 -0.55 1.32e-27 Glomerular filtration rate (creatinine); CRC cis rs6543140 0.964 rs4851592 chr2:103087641 C/T cg09003973 chr2:102972529 NA 0.4 5.77 0.3 1.81e-8 Blood protein levels; CRC trans rs2303319 0.504 rs62189052 chr2:162623869 C/G cg10498984 chr16:28874827 SH2B1 -0.73 -6.28 -0.33 1.04e-9 Cognitive function; CRC cis rs7811142 1.000 rs2406253 chr7:100077273 A/G cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.92 12.27 0.56 9.74e-29 Platelet count; CRC cis rs11212617 0.967 rs4754305 chr11:108075912 T/C cg01991180 chr11:108092276 ATM;NPAT 0.44 6.48 0.34 3.31e-10 Response to metformin in type 2 diabetes (glycemic); CRC cis rs6879260 1.000 rs7730585 chr5:179733440 T/C cg26918954 chr5:179728553 GFPT2 -0.42 -6.87 -0.35 3.29e-11 Height; CRC trans rs2228479 0.850 rs17233455 chr16:89816407 A/G cg21302420 chr1:112162376 RAP1A 0.72 6.01 0.31 5.05e-9 Skin colour saturation; CRC cis rs11031096 0.782 rs4910904 chr11:4165529 C/T cg18678763 chr11:4115507 RRM1 0.42 7.19 0.37 4.38e-12 Mean corpuscular volume;Mean corpuscular hemoglobin; CRC cis rs4862750 0.794 rs7672272 chr4:187896774 T/G cg03452623 chr4:187889614 NA -0.93 -22.01 -0.77 1.17e-66 Lobe attachment (rater-scored or self-reported); CRC cis rs10946940 0.930 rs12215012 chr6:27507494 C/G cg21251018 chr6:28226885 NKAPL -0.4 -6.26 -0.33 1.2e-9 Systemic lupus erythematosus; CRC cis rs4742903 0.933 rs10820608 chr9:106890840 A/G cg21169611 chr9:106856078 SMC2 0.42 5.87 0.31 1.06e-8 High-grade serous ovarian cancer;Breast cancer; CRC cis rs6951245 1.000 rs6951245 chr7:1058193 G/A cg22907277 chr7:1156413 C7orf50 0.69 7.23 0.37 3.46e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs1862618 0.525 rs832403 chr5:56265992 G/T cg18230493 chr5:56204884 C5orf35 0.8 10.4 0.5 4.33e-22 Initial pursuit acceleration; CRC cis rs514406 0.679 rs11585495 chr1:53244331 T/C cg25767906 chr1:53392781 SCP2 0.52 8.1 0.41 1.05e-14 Monocyte count; CRC cis rs9303542 0.559 rs2229302 chr17:46620402 G/A cg04904318 chr17:46607828 HOXB1 -0.53 -6.12 -0.32 2.64e-9 Ovarian cancer;Epithelial ovarian cancer; CRC cis rs4481887 1.000 rs4360553 chr1:248467092 A/G cg13385794 chr1:248469461 NA 0.38 6.75 0.35 6.74e-11 Common traits (Other); CRC cis rs736408 0.609 rs2268025 chr3:52795224 A/T cg15147215 chr3:52552868 STAB1 -0.62 -10.16 -0.49 2.75e-21 Bipolar disorder; CRC cis rs10089 1.000 rs3816006 chr5:127450581 T/A cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.71 9.9 0.48 2.11e-20 Ileal carcinoids; CRC cis rs3796352 1.000 rs35720014 chr3:52982110 A/C cg07884673 chr3:53033167 SFMBT1 0.76 6.12 0.32 2.68e-9 Immune reponse to smallpox (secreted IL-2); CRC cis rs10504229 0.775 rs17216236 chr8:58159352 G/A cg02725872 chr8:58115012 NA -0.59 -9.19 -0.45 4.66e-18 Developmental language disorder (linguistic errors); CRC cis rs853679 1.000 rs853679 chr6:28296863 C/A cg15786705 chr6:28176104 NA 0.55 5.97 0.31 6.08e-9 Depression; CRC cis rs1005277 0.602 rs1740743 chr10:38519222 C/T cg25427524 chr10:38739819 LOC399744 -0.79 -14.49 -0.62 3.78e-37 Extrinsic epigenetic age acceleration; CRC cis rs3889199 0.924 rs60199046 chr1:59663341 A/G cg25881383 chr1:59680599 NA -0.39 -6.23 -0.32 1.41e-9 Pulse pressure; CRC trans rs4332037 0.664 rs73046334 chr7:1887037 T/C cg11693508 chr17:37793320 STARD3 0.64 8.23 0.41 4.39e-15 Bipolar disorder; CRC cis rs728616 0.681 rs35420115 chr10:81908188 A/G cg11900509 chr10:81946545 ANXA11 -0.74 -8.44 -0.42 1.06e-15 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs9326248 1.000 rs4938344 chr11:117003749 G/A cg11861562 chr11:117069780 TAGLN 0.38 8.08 0.41 1.28e-14 Blood protein levels; CRC cis rs2050392 0.630 rs303428 chr10:30739058 C/T cg25182066 chr10:30743637 MAP3K8 0.5 7.0 0.36 1.44e-11 Inflammatory bowel disease; CRC cis rs10927875 0.830 rs1763610 chr1:16335527 C/G cg22431228 chr1:16359049 CLCNKA 0.37 6.52 0.34 2.71e-10 Dilated cardiomyopathy; CRC cis rs3768617 0.510 rs10911242 chr1:183072147 C/T ch.1.3577855R chr1:183094577 LAMC1 0.87 15.12 0.64 1.37e-39 Fuchs's corneal dystrophy; CRC cis rs7705042 0.793 rs7705547 chr5:141514027 A/G cg07392085 chr5:141489673 NDFIP1 0.45 7.26 0.37 2.75e-12 Asthma; CRC cis rs2115630 0.967 rs12595786 chr15:85336670 T/C cg09876464 chr15:85330779 ZNF592 0.45 7.74 0.39 1.2e-13 P wave terminal force; CRC cis rs6952808 0.689 rs11771625 chr7:2050401 C/T cg02951883 chr7:2050386 MAD1L1 -0.8 -13.14 -0.59 5.28e-32 Bipolar disorder and schizophrenia; CRC cis rs9807989 0.507 rs6743516 chr2:103036335 A/G cg03938978 chr2:103052716 IL18RAP 0.59 10.13 0.49 3.5e-21 Asthma; CRC cis rs9388451 0.903 rs7758115 chr6:126061502 C/T cg05901451 chr6:126070800 HEY2 -0.66 -11.54 -0.54 4.24e-26 Brugada syndrome; CRC cis rs4713118 0.786 rs200503 chr6:27785882 A/G cg26587870 chr6:27730563 NA -0.41 -5.64 -0.3 3.61e-8 Parkinson's disease; CRC cis rs1691799 0.899 rs1168300 chr12:66736467 C/A cg16791601 chr12:66731901 HELB -0.66 -10.92 -0.52 6.61e-24 White blood cell count (basophil); CRC cis rs6662572 0.737 rs7552810 chr1:46452823 A/C cg08644498 chr1:46502608 NA 0.46 7.23 0.37 3.4e-12 Blood protein levels; CRC cis rs2976388 1.000 rs2294010 chr8:143762430 A/G cg20041105 chr8:143859282 LYNX1 -0.32 -5.66 -0.3 3.28e-8 Urinary tract infection frequency; CRC cis rs6952407 1 rs6952407 chr7:66045512 A/G cg11764359 chr7:65958608 NA -0.56 -8.45 -0.42 9.87e-16 Cotinine glucuronidation; CRC cis rs863345 0.625 rs950487 chr1:158460130 A/T cg12129480 chr1:158549410 OR10X1 -0.29 -6.04 -0.32 4.2e-9 Pneumococcal bacteremia; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg24198128 chr19:18682398 UBA52 0.5 6.53 0.34 2.49e-10 Thyroid stimulating hormone; CRC cis rs9649213 0.586 rs11768599 chr7:97974555 C/T cg09267113 chr7:98030324 BAIAP2L1 -0.9 -11.78 -0.54 5.77e-27 Prostate cancer (SNP x SNP interaction); CRC cis rs2243480 0.901 rs2900904 chr7:65204264 C/G cg18252515 chr7:66147081 NA -1.16 -13.27 -0.59 1.71e-32 Diabetic kidney disease; CRC cis rs780096 0.506 rs780100 chr2:27652153 G/T cg27432699 chr2:27873401 GPN1 -0.49 -7.55 -0.38 4.26e-13 Total body bone mineral density; CRC cis rs62064224 0.560 rs12162135 chr17:30805795 A/C cg18200150 chr17:30822561 MYO1D 0.63 13.69 0.6 4.55e-34 Schizophrenia; CRC cis rs2204008 0.837 rs4432085 chr12:38181146 C/T cg13010199 chr12:38710504 ALG10B 0.48 6.07 0.32 3.57e-9 Bladder cancer; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg07231102 chr3:19988460 RAB5A 0.4 6.04 0.32 4.23e-9 Intelligence (multi-trait analysis); CRC trans rs931812 0.829 rs13266662 chr8:101916156 C/T cg20993868 chr7:22813445 NA 0.4 7.79 0.39 8.81e-14 Attention deficit hyperactivity disorder and conduct disorder; CRC cis rs6088580 0.601 rs6059827 chr20:33016358 C/T cg24642439 chr20:33292090 TP53INP2 0.39 6.77 0.35 6.06e-11 Glomerular filtration rate (creatinine); CRC cis rs1552244 1.000 rs112847840 chr3:10101652 C/T cg18598329 chr3:10140678 FANCD2;C3orf24 -0.87 -11.82 -0.55 4.24e-27 Alzheimer's disease; CRC cis rs9311474 0.629 rs11709284 chr3:52559705 G/A cg01758942 chr3:52551074 STAB1 0.3 5.94 0.31 7.07e-9 Electroencephalogram traits; CRC trans rs7618501 1.000 rs9855505 chr3:49792158 T/G cg21665057 chr3:196295764 WDR53;FBXO45 -0.86 -15.73 -0.66 5.59e-42 Intelligence (multi-trait analysis); CRC cis rs116095464 0.558 rs6878087 chr5:223117 C/T cg22496380 chr5:211416 CCDC127 0.78 9.05 0.45 1.27e-17 Breast cancer; CRC cis rs8031584 0.918 rs34331396 chr15:31248736 C/G cg14829155 chr15:31115871 NA -0.5 -8.09 -0.41 1.13e-14 Huntington's disease progression; CRC cis rs4731207 0.565 rs7811203 chr7:124653374 T/C cg23710748 chr7:124431027 NA -0.39 -6.17 -0.32 1.99e-9 Cutaneous malignant melanoma; CRC cis rs17152411 0.895 rs7086128 chr10:126587373 A/G cg07906193 chr10:126599966 NA 0.58 6.83 0.35 4.2e-11 Height; CRC cis rs17401966 0.965 rs12751375 chr1:10291874 C/G cg19773385 chr1:10388646 KIF1B -0.57 -7.88 -0.4 4.99e-14 Hepatocellular carcinoma; CRC cis rs35146811 0.771 rs6465762 chr7:99620554 G/A cg13334819 chr7:99746414 C7orf59 -0.58 -7.93 -0.4 3.36e-14 Coronary artery disease; CRC cis rs10504229 0.683 rs7459925 chr8:58111771 G/A cg05313129 chr8:58192883 C8orf71 -0.42 -5.85 -0.31 1.16e-8 Developmental language disorder (linguistic errors); CRC cis rs2880765 0.835 rs4843062 chr15:86040137 A/G cg17133734 chr15:86042851 AKAP13 0.42 6.6 0.34 1.69e-10 Coronary artery disease; CRC cis rs12024301 0.557 rs28595511 chr1:183661833 T/C cg11505048 chr1:183622726 RGL1;APOBEC4 0.71 6.24 0.33 1.33e-9 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs9916302 0.707 rs11078903 chr17:37631924 G/A cg00129232 chr17:37814104 STARD3 -0.53 -7.84 -0.4 6.29e-14 Glomerular filtration rate (creatinine); CRC cis rs60843830 0.623 rs55932737 chr2:107543 C/T cg25945732 chr2:264204 ACP1;SH3YL1 0.46 6.42 0.33 4.7e-10 Spherical equivalent (joint analysis main effects and education interaction); CRC cis rs2228479 0.850 rs62054640 chr16:89823157 C/T cg06558623 chr16:89946397 TCF25 1.13 10.45 0.5 2.85e-22 Skin colour saturation; CRC cis rs7119 0.717 rs34194537 chr15:77795761 G/A cg17802220 chr15:77601643 NA -0.45 -6.42 -0.33 4.74e-10 Type 2 diabetes; CRC cis rs72717009 0.825 rs7539468 chr1:161477066 G/A cg10431340 chr1:161279108 MPZ -0.52 -6.96 -0.36 1.84e-11 Rheumatoid arthritis; CRC cis rs637571 0.522 rs542332 chr11:65744421 C/T cg02427764 chr11:65769310 BANF1;EIF1AD 0.39 5.67 0.3 3.09e-8 Eosinophil percentage of white cells; CRC cis rs10492096 0.947 rs11064227 chr12:6598043 A/G cg07142400 chr12:6602447 NCAPD2;MRPL51 -0.48 -5.66 -0.3 3.24e-8 Hip geometry; CRC cis rs116095464 0.558 rs10462754 chr5:246669 T/C cg22857025 chr5:266934 NA -1.25 -16.72 -0.68 7.53e-46 Breast cancer; CRC cis rs8141529 0.702 rs8137262 chr22:29292135 C/T cg02153584 chr22:29168773 CCDC117 0.46 6.62 0.34 1.42e-10 Lymphocyte counts; CRC cis rs7647973 0.593 rs7652179 chr3:49808618 T/A cg03060546 chr3:49711283 APEH -0.62 -6.92 -0.36 2.31e-11 Menarche (age at onset); CRC cis rs3820928 0.874 rs6717168 chr2:227901342 C/T cg11843606 chr2:227700838 RHBDD1 -0.38 -5.62 -0.3 4e-8 Pulmonary function; CRC cis rs72634258 0.945 rs7517357 chr1:8025275 C/T cg00042356 chr1:8021962 PARK7 0.69 7.27 0.37 2.7e-12 Inflammatory bowel disease; CRC cis rs6662572 0.737 rs2067635 chr1:46537946 T/G cg08644498 chr1:46502608 NA 0.45 7.07 0.36 9.62e-12 Blood protein levels; CRC cis rs7215564 0.908 rs35361366 chr17:78684751 T/C cg09596252 chr17:78655493 RPTOR 0.56 6.15 0.32 2.22e-9 Myopia (pathological); CRC cis rs10512697 0.772 rs34012000 chr5:3536248 T/C cg19473799 chr5:3511975 NA -0.78 -6.0 -0.31 5.14e-9 Immune response to smallpox vaccine (IL-6); CRC cis rs2692947 0.832 rs62153679 chr2:96558400 C/T cg22654517 chr2:96458247 NA 0.32 5.72 0.3 2.43e-8 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; CRC trans rs35110281 0.811 rs1122873 chr21:45044672 G/C cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.53 9.15 0.45 6.11e-18 Mean corpuscular volume; CRC cis rs1800469 1.000 rs2317130 chr19:41861674 C/T cg08477640 chr19:41863820 B9D2 0.54 7.6 0.39 3.09e-13 Colorectal cancer; CRC cis rs6460942 0.841 rs17443848 chr7:12443688 A/G cg06484146 chr7:12443880 VWDE -0.73 -9.34 -0.46 1.55e-18 Coronary artery disease; CRC cis rs854765 0.647 rs854790 chr17:18028318 C/G cg09796270 chr17:17721594 SREBF1 0.39 6.16 0.32 2.09e-9 Total body bone mineral density; CRC cis rs13108904 0.934 rs13128045 chr4:1305309 C/T cg00684032 chr4:1343700 KIAA1530 0.44 6.33 0.33 8.09e-10 Obesity-related traits; CRC cis rs1008375 1.000 rs3933453 chr4:17636319 A/C cg16339924 chr4:17578868 LAP3 0.52 7.04 0.36 1.1e-11 Parasitemia in Tripanosoma cruzi seropositivity; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg08293760 chr1:220445750 RAB3GAP2 0.46 6.28 0.33 1.05e-9 Response to antipsychotic treatment; CRC cis rs2486012 1.000 rs1548634 chr1:44399608 T/C cg12908607 chr1:44402522 ARTN 0.43 5.72 0.3 2.37e-8 Intelligence (multi-trait analysis); CRC cis rs16867335 1.000 rs11887445 chr2:181490442 C/T cg23363182 chr2:181467187 NA -0.49 -6.7 -0.35 9.01e-11 Survival in rectal cancer; CRC cis rs9649465 0.967 rs2299986 chr7:123369539 T/C cg03229431 chr7:123269106 ASB15 -0.36 -5.67 -0.3 3.21e-8 Migraine; CRC trans rs2303319 0.504 rs1449641 chr2:162619567 T/C cg03774468 chr3:140950104 ACPL2 -0.65 -6.07 -0.32 3.46e-9 Cognitive function; CRC cis rs1707322 1.000 rs9429186 chr1:46539687 C/T cg06784218 chr1:46089804 CCDC17 -0.54 -9.36 -0.46 1.25e-18 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs4680 0.737 rs4646312 chr22:19948337 C/T cg23601416 chr22:19950040 COMT 0.32 8.79 0.44 8.42e-17 Blood metabolite levels; CRC cis rs6061231 1.000 rs13043313 chr20:60958269 A/G cg24112000 chr20:60950667 NA -0.62 -10.21 -0.49 1.86e-21 Colorectal cancer; CRC trans rs7618501 0.933 rs3811695 chr3:49761613 C/T cg21659725 chr3:3221576 CRBN -0.9 -17.32 -0.69 3.07e-48 Intelligence (multi-trait analysis); CRC cis rs9372498 0.536 rs77435770 chr6:118819467 G/A cg24463073 chr6:118973353 C6orf204 0.52 6.97 0.36 1.69e-11 Diastolic blood pressure; CRC cis rs12188164 0.965 rs41282625 chr5:475626 C/G cg14137381 chr5:502291 SLC9A3 -0.32 -5.63 -0.3 3.91e-8 Cystic fibrosis severity; CRC cis rs1953600 0.870 rs2788296 chr10:81937889 G/A cg04850286 chr10:81895943 PLAC9 0.38 6.72 0.35 7.9e-11 Sarcoidosis; CRC cis rs7589728 0.514 rs12465706 chr2:88467459 C/A cg18490616 chr2:88469792 THNSL2 0.58 5.85 0.31 1.22e-8 Plasma clusterin levels; CRC cis rs12477438 0.501 rs11683188 chr2:99724512 T/C cg14399236 chr2:99771627 LIPT1;TSGA10 0.72 12.02 0.55 7.68e-28 Chronic sinus infection; CRC cis rs7760949 0.963 rs9396248 chr6:13906360 A/G cg27413430 chr6:13925136 RNF182 0.31 5.65 0.3 3.53e-8 Mean corpuscular hemoglobin concentration; CRC cis rs2932538 0.922 rs9429694 chr1:113158289 G/A cg22162597 chr1:113214053 CAPZA1 0.74 10.58 0.5 1.03e-22 Systolic blood pressure;Diastolic blood pressure;Hypertension;Blood pressure; CRC cis rs12760731 0.565 rs34593395 chr1:178129488 C/T cg00404053 chr1:178313656 RASAL2 1.09 11.33 0.53 2.46e-25 Obesity-related traits; CRC cis rs7586879 0.639 rs13407913 chr2:25097644 A/G cg04586622 chr2:25135609 ADCY3 -0.56 -10.45 -0.5 2.87e-22 Body mass index; CRC cis rs910187 0.678 rs6124964 chr20:45812536 T/G cg27589058 chr20:45804311 EYA2 -0.42 -8.19 -0.41 5.85e-15 Migraine; CRC cis rs1949733 0.877 rs940133 chr4:8473614 T/C cg11789530 chr4:8429930 ACOX3 0.82 11.68 0.54 1.28e-26 Response to antineoplastic agents; CRC cis rs875971 0.545 rs6460276 chr7:65647277 G/A cg03233332 chr7:66118400 NA -0.45 -6.38 -0.33 6.02e-10 Aortic root size; CRC cis rs3008870 1.000 rs2985824 chr1:67410171 C/T cg08660285 chr1:67390436 MIER1;WDR78 -1.01 -15.22 -0.64 5.49e-40 Lymphocyte percentage of white cells; CRC cis rs2840044 1.000 rs11656138 chr17:33910218 T/C cg05299278 chr17:33885742 SLFN14 -0.4 -6.08 -0.32 3.39e-9 Response to radiotherapy in cancer (late toxicity); CRC cis rs3796352 1.000 rs35849389 chr3:53005235 A/G cg27565382 chr3:53032988 SFMBT1 0.7 6.21 0.32 1.63e-9 Immune reponse to smallpox (secreted IL-2); CRC cis rs2070488 0.662 rs7373930 chr3:38454931 A/G cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.56 8.07 0.41 1.32e-14 Electrocardiographic conduction measures; CRC cis rs4713118 0.505 rs276371 chr6:27910708 A/T cg25164649 chr6:28176230 NA 0.41 5.7 0.3 2.73e-8 Parkinson's disease; CRC cis rs9660180 0.868 rs72634846 chr1:1704915 C/G cg05132306 chr1:1846340 CALML6 -0.45 -6.93 -0.36 2.26e-11 Body mass index; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg10972625 chr1:143745140 LOC100286793;FLJ39739 -0.45 -6.85 -0.35 3.62e-11 Liver disease severity in Alagille syndrome; CRC cis rs6700896 0.897 rs11208696 chr1:66121781 T/G cg04111102 chr1:66153794 NA 0.34 5.92 0.31 8.22e-9 C-reactive protein;Mean corpuscular volume;Mean corpuscular hemoglobin; CRC cis rs67340775 0.541 rs200965 chr6:27866384 G/A cg12273811 chr6:28175739 NA 0.6 6.11 0.32 2.84e-9 Lung cancer in ever smokers; CRC cis rs6570726 0.791 rs398408 chr6:145801020 G/A cg23711669 chr6:146136114 FBXO30 0.72 12.5 0.57 1.35e-29 Lobe attachment (rater-scored or self-reported); CRC cis rs4969178 0.965 rs12944051 chr17:76395856 C/T cg20026190 chr17:76395443 PGS1 -0.39 -5.93 -0.31 7.7e-9 HDL cholesterol levels; CRC cis rs919433 0.927 rs6759834 chr2:198204860 C/T cg20885578 chr2:198174922 NA -0.37 -5.69 -0.3 2.83e-8 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC trans rs9329221 0.657 rs17694485 chr8:10114458 A/T cg16141378 chr3:129829833 LOC729375 -0.43 -5.96 -0.31 6.37e-9 Neuroticism; CRC cis rs6502050 0.835 rs6502065 chr17:80095642 T/C cg02741985 chr17:80059408 CCDC57 0.43 7.15 0.37 5.66e-12 Life satisfaction; CRC cis rs919433 0.680 rs2565160 chr2:198286474 A/G cg10820045 chr2:198174542 NA 0.39 6.55 0.34 2.2e-10 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC cis rs11608355 0.545 rs2302709 chr12:109893697 A/G cg05360138 chr12:110035743 NA 0.77 8.7 0.43 1.65e-16 Neuroticism; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg05976695 chr10:7860543 TAF3 0.46 6.27 0.33 1.16e-9 Anxiety disorder; CRC cis rs17401966 0.838 rs946501 chr1:10309580 C/G cg19773385 chr1:10388646 KIF1B -0.68 -11.18 -0.52 8.34e-25 Hepatocellular carcinoma; CRC cis rs9910055 0.509 rs9916444 chr17:42313512 C/G cg13607699 chr17:42295918 UBTF 0.76 12.89 0.58 4.89e-31 Total body bone mineral density; CRC cis rs782590 0.764 rs2586970 chr2:55829967 A/G cg18811423 chr2:55921094 PNPT1 0.79 13.94 0.61 4.99e-35 Metabolic syndrome; CRC cis rs1965732 1.000 rs6707320 chr2:3708966 A/G cg25251562 chr2:3704773 ALLC -0.43 -6.2 -0.32 1.65e-9 Response to inhaled corticosteroid treatment in asthma (change in FEV1); CRC trans rs12310956 0.515 rs1852221 chr12:33945489 G/T cg26384229 chr12:38710491 ALG10B 0.47 6.44 0.33 4.25e-10 Morning vs. evening chronotype; CRC cis rs11112613 0.713 rs11112587 chr12:105941285 G/A cg03607813 chr12:105948248 NA 0.77 10.2 0.49 2.03e-21 Corrected insulin response;Corrected insulin response adjusted for insulin sensitivity index; CRC cis rs2070677 0.935 rs2070676 chr10:135351137 C/G cg20169779 chr10:135381914 SYCE1 0.78 11.36 0.53 1.94e-25 Gout; CRC trans rs11148252 0.574 rs3742297 chr13:53278067 T/C cg18335740 chr13:41363409 SLC25A15 0.79 14.4 0.62 8.33e-37 Lewy body disease; CRC cis rs9341808 0.718 rs9361584 chr6:80819946 G/C cg08355045 chr6:80787529 NA 0.43 6.88 0.35 2.95e-11 Sitting height ratio; CRC cis rs763121 0.853 rs4821816 chr22:39113134 G/A cg06544989 chr22:39130855 UNC84B 0.47 7.44 0.38 8.98e-13 Menopause (age at onset); CRC cis rs2243480 1.000 rs34577383 chr7:65385726 C/T cg12463550 chr7:65579703 CRCP 0.63 6.04 0.32 4.17e-9 Diabetic kidney disease; CRC trans rs7267979 1.000 rs2387881 chr20:25378172 A/G cg17903999 chr18:56338584 MALT1 0.4 6.55 0.34 2.25e-10 Liver enzyme levels (alkaline phosphatase); CRC cis rs992157 0.560 rs12987130 chr2:219104990 T/C cg00012203 chr2:219082015 ARPC2 -0.54 -8.47 -0.42 8.01e-16 Colorectal cancer; CRC cis rs9393777 0.841 rs34332556 chr6:27357414 C/G cg26958806 chr6:27640298 NA 0.85 5.66 0.3 3.23e-8 Intelligence (multi-trait analysis); CRC cis rs17376456 0.569 rs6895356 chr5:93060781 A/G cg09848695 chr5:92956644 FAM172A;MIR2277 0.5 5.89 0.31 9.46e-9 Diabetic retinopathy; CRC cis rs9826463 0.757 rs73240310 chr3:142240459 T/C cg20824294 chr3:142316082 PLS1 0.41 6.89 0.36 2.77e-11 QRS duration in Tripanosoma cruzi seropositivity; CRC cis rs897984 0.683 rs8050330 chr16:30824970 C/T cg00531865 chr16:30841666 NA -0.48 -6.94 -0.36 2.14e-11 Dementia with Lewy bodies; CRC cis rs9916302 0.904 rs7503705 chr17:37669704 A/G cg07936489 chr17:37558343 FBXL20 -0.84 -13.25 -0.59 2.04e-32 Glomerular filtration rate (creatinine); CRC cis rs9894429 1.000 rs9894429 chr17:79596811 C/T cg21028142 chr17:79581711 NPLOC4 0.38 8.32 0.42 2.38e-15 Eye color traits; CRC cis rs2457480 0.516 rs10899992 chr10:44648515 C/T cg09554077 chr10:44749378 NA 0.46 5.9 0.31 8.85e-9 Coronary artery disease; CRC cis rs9612 1.000 rs346528 chr19:44259232 G/T cg08581076 chr19:44259116 C19orf61 0.49 6.28 0.33 1.06e-9 Exhaled nitric oxide output; CRC cis rs7617480 0.648 rs9882443 chr3:48749064 G/A cg20833759 chr3:49053208 WDR6;DALRD3 0.65 9.88 0.48 2.55e-20 Subjective well-being (multi-trait analysis);Menarche (age at onset); CRC cis rs4363385 0.747 rs11205149 chr1:152958840 C/T cg25856811 chr1:152973957 SPRR3 -0.26 -7.28 -0.37 2.52e-12 Inflammatory skin disease; CRC cis rs995000 0.931 rs10889343 chr1:63026429 T/G cg19896129 chr1:63156450 NA -0.43 -6.67 -0.35 1.06e-10 Triglyceride levels; CRC cis rs1670533 1.000 rs2045065 chr4:1052488 A/G cg27284194 chr4:1044797 NA 0.51 6.31 0.33 9.25e-10 Recombination rate (females); CRC cis rs10782582 0.609 rs78776851 chr1:76424845 T/C cg03433033 chr1:76189801 ACADM -0.42 -5.87 -0.31 1.09e-8 Daytime sleep phenotypes; CRC cis rs3806843 0.676 rs778593 chr5:140027216 T/C cg19875535 chr5:140030758 IK -0.68 -11.49 -0.54 6.33e-26 Depressive symptoms (multi-trait analysis); CRC cis rs1878931 0.726 rs3843728 chr16:3448251 T/C cg26668626 chr16:3451006 ZNF174;ZNF434 1.01 17.68 0.7 1.27e-49 Body mass index (adult); CRC cis rs3749237 0.557 rs7631908 chr3:49425707 T/G cg02487422 chr3:49467188 NICN1 0.42 6.89 0.35 2.9100000000000002e-11 Resting heart rate; CRC cis rs763121 0.889 rs4820335 chr22:38935927 C/G cg06022373 chr22:39101656 GTPBP1 -0.7 -10.82 -0.51 1.56e-23 Menopause (age at onset); CRC cis rs55702914 0.712 rs12619296 chr2:198148767 A/G cg03934865 chr2:198174659 NA -0.36 -6.29 -0.33 9.91e-10 Major depression and alcohol dependence; CRC cis rs4820539 1.000 rs2157710 chr22:23457486 C/T cg14186256 chr22:23484241 RTDR1 0.87 16.77 0.68 4.79e-46 Bone mineral density; CRC cis rs853679 0.882 rs9468287 chr6:28079741 G/T cg03623178 chr6:28175578 NA 0.83 6.66 0.34 1.12e-10 Depression; CRC cis rs9611565 0.918 rs4822024 chr22:41757647 G/A cg06481639 chr22:41940642 POLR3H -0.49 -6.15 -0.32 2.26e-9 Vitiligo; CRC cis rs17345786 0.906 rs56171035 chr3:101111108 G/C cg12386194 chr3:101231763 SENP7 0.56 7.31 0.37 2.08e-12 Colonoscopy-negative controls vs population controls; CRC cis rs68170813 0.523 rs10253172 chr7:106786474 C/T cg02696742 chr7:106810147 HBP1 0.58 6.68 0.35 1.02e-10 Coronary artery disease; CRC cis rs2576037 0.796 rs2571032 chr18:44578250 T/A cg07416455 chr18:44543612 TCEB3CL;KATNAL2 0.42 6.12 0.32 2.71e-9 Personality dimensions; CRC cis rs4654899 0.865 rs6685831 chr1:21507888 G/A cg02927042 chr1:21476669 EIF4G3 -0.5 -7.9 -0.4 4.36e-14 Superior frontal gyrus grey matter volume; CRC cis rs7487075 0.786 rs59919892 chr12:46712230 A/G cg22049899 chr12:47219821 SLC38A4 0.34 6.54 0.34 2.31e-10 Itch intensity from mosquito bite; CRC cis rs6500395 1.000 rs1558817 chr16:48730722 G/A cg04672837 chr16:48644449 N4BP1 0.43 6.07 0.32 3.6e-9 Response to tocilizumab in rheumatoid arthritis; CRC cis rs11628318 0.614 rs10140498 chr14:103154191 A/G cg08075719 chr14:103021372 NA 0.54 6.67 0.35 1.08e-10 Platelet count; CRC cis rs8072100 0.934 rs8067286 chr17:45594590 A/G cg25173405 chr17:45401733 C17orf57 0.47 7.26 0.37 2.85e-12 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs12449964 0.524 rs4925092 chr17:17568931 A/G cg09796270 chr17:17721594 SREBF1 0.47 8.06 0.41 1.39e-14 Coronary artery disease or ischemic stroke; CRC cis rs853679 0.517 rs17711801 chr6:28092307 C/G cg21251018 chr6:28226885 NKAPL 0.48 6.33 0.33 7.86e-10 Depression; CRC trans rs3780486 0.718 rs3818593 chr9:33120706 A/G cg20290983 chr6:43655470 MRPS18A 0.95 12.11 0.56 3.67e-28 IgG glycosylation; CRC cis rs3741404 0.560 rs12362602 chr11:63908660 G/A cg06243084 chr11:63990629 FERMT3 0.45 7.24 0.37 3.16e-12 Platelet count; CRC cis rs12200560 0.505 rs2387378 chr6:97077504 C/A cg06623918 chr6:96969491 KIAA0776 0.52 7.77 0.39 1.02e-13 Coronary heart disease; CRC trans rs11088226 0.681 rs2833902 chr21:33940458 A/G cg09050820 chr6:167586206 TCP10L2 0.81 8.53 0.43 5.43e-16 Gastritis; CRC cis rs9910055 1.000 rs2071167 chr17:42287519 A/G cg13607699 chr17:42295918 UBTF -0.65 -9.76 -0.47 6.46e-20 Total body bone mineral density; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg14671666 chr5:41904456 C5orf51 0.44 6.16 0.32 2.1e-9 Anxiety disorder; CRC cis rs6570726 0.791 rs6915094 chr6:145883540 C/G cg05347473 chr6:146136440 FBXO30 0.41 6.15 0.32 2.19e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs425277 1.000 rs427811 chr1:2075560 T/G cg24578937 chr1:2090814 PRKCZ 0.66 11.81 0.55 4.44e-27 Height; CRC cis rs1048238 0.545 rs848199 chr1:16292742 C/T cg21385522 chr1:16154831 NA -0.62 -9.01 -0.45 1.67e-17 Systolic blood pressure; CRC cis rs7666738 0.830 rs7678250 chr4:98922109 G/A cg05340658 chr4:99064831 C4orf37 0.6 9.35 0.46 1.41e-18 Colonoscopy-negative controls vs population controls; CRC cis rs11758351 0.866 rs2022448 chr6:26207928 C/T cg10723962 chr6:26240782 HIST1H4F -0.34 -6.05 -0.32 3.84e-9 Gout;Renal underexcretion gout; CRC cis rs6543140 0.964 rs6736135 chr2:103064924 A/G cg03938978 chr2:103052716 IL18RAP 0.45 7.1 0.36 7.53e-12 Blood protein levels; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg07555797 chr14:61788314 PRKCH 0.37 6.1 0.32 3.05e-9 Liver disease severity in Alagille syndrome; CRC cis rs939658 0.776 rs11631411 chr15:79445816 C/T cg17916960 chr15:79447300 NA -0.45 -7.44 -0.38 9.02e-13 Refractive error; CRC trans rs1973993 0.689 rs17115225 chr1:96884330 C/T cg10631902 chr5:14652156 NA -0.43 -7.05 -0.36 1.06e-11 Weight; CRC cis rs1008375 0.931 rs3796814 chr4:17602033 G/C cg16339924 chr4:17578868 LAP3 0.48 6.42 0.33 4.64e-10 Parasitemia in Tripanosoma cruzi seropositivity; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg07976860 chr16:67281332 FHOD1 0.37 6.37 0.33 6.49e-10 Liver disease severity in Alagille syndrome; CRC trans rs2303319 0.504 rs56260047 chr2:162497225 G/T cg13490827 chr1:46269305 MAST2 -0.7 -6.28 -0.33 1.09e-9 Cognitive function; CRC cis rs6696846 0.749 rs11578293 chr1:205070178 T/C cg00857998 chr1:205179979 DSTYK 0.41 5.8 0.3 1.57e-8 Red blood cell count; CRC cis rs12893668 0.628 rs57072546 chr14:104063723 T/C cg24130564 chr14:104152367 KLC1 -0.42 -5.66 -0.3 3.36e-8 Reticulocyte count; CRC cis rs10540 0.908 rs71487293 chr11:486414 G/A cg08200582 chr11:442649 ANO9 -0.7 -7.12 -0.37 6.8e-12 Body mass index; CRC cis rs516243 0.703 rs284313 chr1:10736434 A/G cg02903756 chr1:10750680 CASZ1 -0.5 -8.71 -0.43 1.46e-16 Migraine - clinic-based; CRC cis rs6121246 0.580 rs6121016 chr20:30245239 C/T cg07809909 chr20:30433512 FOXS1 0.35 5.64 0.3 3.58e-8 Mean corpuscular hemoglobin; CRC cis rs4665809 0.531 rs10199898 chr2:26445485 T/G cg27170947 chr2:26402098 FAM59B -0.59 -7.71 -0.39 1.53e-13 Gut microbiome composition (summer); CRC cis rs9372498 0.536 rs13437605 chr6:118899014 C/T cg24463073 chr6:118973353 C6orf204 0.52 6.85 0.35 3.69e-11 Diastolic blood pressure; CRC cis rs6761276 0.649 rs3811057 chr2:113831188 C/A cg12858261 chr2:113808755 IL1F8 0.46 6.68 0.35 1.02e-10 Protein quantitative trait loci; CRC cis rs4975709 0.569 rs4975743 chr5:1859941 G/T cg20790798 chr5:1857306 NA -0.46 -6.96 -0.36 1.88e-11 Cardiovascular disease risk factors; CRC cis rs57221529 0.766 rs56350081 chr5:583198 G/A cg09021430 chr5:549028 NA -0.72 -7.9 -0.4 4.17e-14 Lung disease severity in cystic fibrosis; CRC cis rs11971779 0.715 rs7787398 chr7:139061846 A/G cg07862535 chr7:139043722 LUC7L2 0.83 10.67 0.51 5.14e-23 Diisocyanate-induced asthma; CRC cis rs6570726 0.846 rs397311 chr6:145806701 C/T cg23711669 chr6:146136114 FBXO30 -0.65 -11.38 -0.53 1.54e-25 Lobe attachment (rater-scored or self-reported); CRC cis rs7626444 0.584 rs11711813 chr3:196467338 C/T cg12930392 chr3:196481615 PAK2 0.38 6.66 0.34 1.14e-10 Monocyte count; CRC cis rs35146811 0.657 rs36019559 chr7:99814586 A/G cg00553149 chr7:99775558 STAG3;GPC2 -0.24 -5.61 -0.3 4.38e-8 Coronary artery disease; CRC cis rs17253792 0.732 rs75796044 chr14:56034128 C/T cg01858014 chr14:56050164 KTN1 -0.84 -7.78 -0.39 9.76e-14 Putamen volume; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg12625874 chr1:1284440 DVL1 0.41 6.0 0.31 5.19e-9 Intelligence (multi-trait analysis); CRC trans rs7481584 0.564 rs7948848 chr11:2981896 G/A cg12244665 chr8:104325860 FZD6 -0.33 -5.98 -0.31 5.79e-9 Calcium levels; CRC cis rs9527 0.615 rs10883810 chr10:104727224 A/C cg15744005 chr10:104629667 AS3MT -0.31 -6.22 -0.32 1.54e-9 Arsenic metabolism; CRC cis rs62064224 0.714 rs11653974 chr17:30635002 T/C cg25833597 chr17:30823145 MYO1D 0.34 5.64 0.3 3.7e-8 Schizophrenia; CRC cis rs7618915 0.571 rs2289249 chr3:52597664 G/A cg18099408 chr3:52552593 STAB1 -0.45 -7.39 -0.38 1.22e-12 Bipolar disorder; CRC cis rs477692 0.569 rs1711670 chr10:131281115 A/G cg05714579 chr10:131428358 MGMT 0.54 7.65 0.39 2.2e-13 Response to temozolomide; CRC cis rs3815700 1.000 rs8104328 chr19:33094371 G/A cg02997394 chr19:33096574 ANKRD27 0.75 8.68 0.43 1.88e-16 Eosinophilic esophagitis; CRC cis rs1865760 0.534 rs1541988 chr6:25950804 C/A cg16482183 chr6:26056742 HIST1H1C 0.45 6.75 0.35 6.81e-11 Height; CRC trans rs9545047 0.716 rs2265378 chr13:79999716 T/C cg07061582 chr15:90234082 PEX11A;WDR93 -0.41 -5.97 -0.31 6.15e-9 Schizophrenia; CRC cis rs2067615 0.542 rs10861654 chr12:107122896 A/G cg13491945 chr12:107078410 RFX4 0.34 5.87 0.31 1.09e-8 Heart rate; CRC cis rs7680126 0.596 rs28441463 chr4:10289577 T/C cg11266682 chr4:10021025 SLC2A9 -0.39 -6.04 -0.32 4.26e-9 Urate levels in lean individuals;Urate levels in overweight individuals;Urate levels in obese individuals; CRC cis rs4713675 0.565 rs4713670 chr6:33699882 C/T cg14003231 chr6:33640908 ITPR3 -0.46 -7.49 -0.38 6.59e-13 Plateletcrit; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg07376846 chr1:203765385 ZC3H11A 0.46 6.59 0.34 1.74e-10 Intelligence (multi-trait analysis); CRC cis rs3741151 1.000 rs60924672 chr11:73098724 A/C cg17517138 chr11:73019481 ARHGEF17 1.04 8.39 0.42 1.44e-15 GIP levels in response to oral glucose tolerance test (120 minutes); CRC cis rs9325144 0.555 rs1973292 chr12:38679626 T/C cg13010199 chr12:38710504 ALG10B 0.44 6.43 0.33 4.49e-10 Morning vs. evening chronotype; CRC cis rs10479542 0.784 rs4701132 chr5:178985270 A/G cg09060608 chr5:178986726 RUFY1 -0.56 -10.0 -0.48 9.93e-21 Lung cancer; CRC cis rs12142240 0.698 rs61519400 chr1:46855298 A/G cg14993813 chr1:46806288 NSUN4 -0.48 -6.07 -0.32 3.62e-9 Menopause (age at onset); CRC cis rs6674176 0.628 rs3791119 chr1:44431362 C/G cg12908607 chr1:44402522 ARTN -0.54 -9.67 -0.47 1.21e-19 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Cognitive ability; CRC cis rs2243480 1.000 rs34560516 chr7:65404092 A/T cg12463550 chr7:65579703 CRCP 0.67 6.41 0.33 5.16e-10 Diabetic kidney disease; CRC cis rs10504229 1.000 rs67384205 chr8:58180348 C/G cg05313129 chr8:58192883 C8orf71 -0.47 -6.99 -0.36 1.49e-11 Developmental language disorder (linguistic errors); CRC cis rs3889199 0.924 rs12755444 chr1:59681252 A/G cg25881383 chr1:59680599 NA -0.38 -6.28 -0.33 1.08e-9 Pulse pressure; CRC cis rs6968419 0.755 rs2402057 chr7:115897096 C/T cg02561103 chr7:115862891 TES 0.42 6.38 0.33 6.12e-10 Intraocular pressure; CRC cis rs1065656 0.581 rs1065666 chr16:1839134 T/C cg03013636 chr16:1946785 NA -0.47 -5.85 -0.31 1.18e-8 Insulin-like growth factors; CRC trans rs12367572 0.620 rs1857924 chr12:45344212 T/G cg23954465 chr10:8078038 NA -0.28 -6.19 -0.32 1.79e-9 Gut microbiome composition (summer); CRC cis rs7773004 0.936 rs6917995 chr6:26327814 T/C cg13736514 chr6:26305472 NA -0.4 -6.51 -0.34 2.88e-10 Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for body mass index;Waist circumference adjusted for BMI in non-smokers;Waist circumference adjusted for BMI (adjusted for smoking behaviour); CRC cis rs1552244 0.882 rs28366039 chr3:10028988 C/A cg13047869 chr3:10149882 C3orf24 0.49 6.24 0.33 1.38e-9 Alzheimer's disease; CRC cis rs13315871 1.000 rs71311873 chr3:58447106 C/A cg20936604 chr3:58311152 NA -0.73 -7.25 -0.37 3.06e-12 Cholesterol, total; CRC cis rs853679 0.517 rs4713144 chr6:28106790 C/G cg02683197 chr6:28174875 NA 0.85 10.52 0.5 1.71e-22 Depression; CRC cis rs7605827 0.930 rs2287274 chr2:15658577 T/C cg19274914 chr2:15703543 NA 0.38 5.72 0.3 2.4e-8 Educational attainment (years of education); CRC cis rs929354 1.000 rs1182391 chr7:157038368 T/C cg17757837 chr7:157058334 UBE3C -0.85 -15.96 -0.66 7.37e-43 Body mass index; CRC cis rs2153535 0.580 rs6597332 chr6:8504748 C/G cg21535247 chr6:8435926 SLC35B3 0.47 7.23 0.37 3.47e-12 Motion sickness; CRC cis rs56011263 0.687 rs11734460 chr4:705074 C/T cg20735989 chr4:730612 PCGF3 -0.46 -5.74 -0.3 2.21e-8 White blood cell count; CRC cis rs897984 0.568 rs4889651 chr16:30895545 C/T cg02466173 chr16:30829666 NA -0.66 -8.67 -0.43 2.05e-16 Dementia with Lewy bodies; CRC cis rs6831352 1.000 rs6532798 chr4:100054827 C/T cg13256891 chr4:100009986 ADH5 0.61 8.71 0.43 1.48e-16 Alcohol dependence; CRC cis rs720844 0.628 rs16828791 chr2:149296887 C/T cg09247360 chr2:149335327 NA -0.56 -5.83 -0.31 1.3e-8 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs9469578 0.901 rs57303110 chr6:33706159 G/A cg18708504 chr6:33715942 IP6K3 0.6 6.7 0.35 9.31e-11 Phosphorus levels; CRC cis rs13191362 0.938 rs28360532 chr6:162997477 T/C cg06582575 chr6:163149167 PACRG;PARK2 0.77 10.7 0.51 3.98e-23 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC trans rs10021731 0.718 rs1460771 chr4:115407911 C/T cg25927708 chr2:119603813 EN1 0.33 6.29 0.33 1.03e-9 Optic disc area; CRC cis rs6860806 0.507 rs272878 chr5:131671769 C/T cg02033258 chr5:131593261 PDLIM4 -0.37 -6.41 -0.33 5.17e-10 Breast cancer; CRC cis rs375066 0.586 rs2883946 chr19:44352688 G/A cg19542119 chr19:44331823 ZNF283 0.4 5.61 0.3 4.24e-8 Breast cancer; CRC cis rs11098499 0.866 rs10518329 chr4:120401835 A/G cg24375607 chr4:120327624 NA 0.41 6.36 0.33 6.92e-10 Corneal astigmatism; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg18452149 chr3:108308268 KIAA1524;DZIP3 -0.4 -6.29 -0.33 1.01e-9 Myopia (pathological); CRC cis rs5753618 0.561 rs5749265 chr22:31796897 A/C cg22777020 chr22:31556080 RNF185 0.53 6.26 0.33 1.17e-9 Colorectal cancer; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg09253211 chr11:63438586 ATL3 -0.45 -6.85 -0.35 3.64e-11 Myopia (pathological); CRC cis rs4713118 0.869 rs9461400 chr6:27700559 A/G cg12172441 chr6:28176163 NA 0.52 7.19 0.37 4.51e-12 Parkinson's disease; CRC cis rs28386778 0.897 rs9915552 chr17:61869095 G/A cg06601766 chr17:61851465 DDX42;CCDC47 0.46 6.2 0.32 1.66e-9 Prudent dietary pattern; CRC cis rs6120849 0.754 rs7268266 chr20:33581889 T/C cg08999081 chr20:33150536 PIGU 0.46 5.94 0.31 7.15e-9 Protein C levels; CRC cis rs9807989 0.524 rs7591246 chr2:102999403 C/A cg03938978 chr2:103052716 IL18RAP 0.59 10.12 0.49 3.77e-21 Asthma; CRC cis rs873946 0.648 rs12769533 chr10:134548685 C/T cg27286337 chr10:134555280 INPP5A -0.7 -8.67 -0.43 2.04e-16 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CRC cis rs1757171 0.542 rs3818985 chr6:37484214 G/T cg25019722 chr6:37503610 NA -0.41 -7.39 -0.38 1.2e-12 Cognitive performance; CRC cis rs72615157 0.634 rs11762932 chr7:99792666 C/T cg13153964 chr7:100026424 MEPCE;ZCWPW1 -0.81 -9.94 -0.48 1.62e-20 Lung function (FEV1/FVC); CRC cis rs916888 0.773 rs199535 chr17:44822662 A/G cg17911788 chr17:44343683 NA -0.6 -7.03 -0.36 1.19e-11 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs9611565 0.625 rs9611606 chr22:41931074 A/G cg06634786 chr22:41940651 POLR3H -0.66 -7.66 -0.39 2.04e-13 Vitiligo; CRC trans rs11989744 0.597 rs11135768 chr8:23573278 A/G cg03492747 chr16:86543808 FOXF1 0.5 9.02 0.45 1.63e-17 Waist-hip ratio; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg12450255 chr15:34659304 LPCAT4 0.47 6.06 0.32 3.74e-9 Thyroid stimulating hormone; CRC cis rs2204008 0.744 rs8186814 chr12:38335169 C/T cg13010199 chr12:38710504 ALG10B 0.46 6.1 0.32 3.04e-9 Bladder cancer; CRC cis rs5758511 0.731 rs5751186 chr22:42349710 G/A cg00645731 chr22:42541494 CYP2D7P1 -0.47 -7.0 -0.36 1.47e-11 Birth weight; CRC cis rs875971 1.000 rs1144895 chr7:65541307 C/G cg18912574 chr7:65842487 NCRNA00174 -0.37 -6.32 -0.33 8.29e-10 Aortic root size; CRC cis rs172166 0.611 rs203882 chr6:28078502 G/A cg20615401 chr6:28092323 ZSCAN16 0.45 5.9 0.31 9.1e-9 Cardiac Troponin-T levels; CRC cis rs9467711 0.591 rs10484433 chr6:26030492 G/T cg16898833 chr6:26189333 HIST1H4D 0.66 5.77 0.3 1.8e-8 Autism spectrum disorder or schizophrenia; CRC cis rs870825 0.616 rs6552804 chr4:185637699 A/G cg04058563 chr4:185651563 MLF1IP 0.73 9.38 0.46 1.13e-18 Blood protein levels; CRC trans rs12439619 0.739 rs4778988 chr15:82540337 T/C cg04831495 chr15:85060580 GOLGA6L5 -0.5 -7.1 -0.36 7.69e-12 Intelligence (multi-trait analysis); CRC cis rs1950626 0.743 rs1956734 chr14:101399830 A/T cg02351406 chr14:101447389 SNORD114-20;SNORD114-21 -0.89 -13.53 -0.6 1.86e-33 Pelvic organ prolapse (moderate/severe); CRC cis rs12048904 0.619 rs10783153 chr1:101328230 T/C cg00063077 chr1:101360652 SLC30A7;EXTL2 0.8 12.15 0.56 2.51e-28 Multiple sclerosis; CRC cis rs9614461 0.826 rs9614649 chr22:45746097 C/A cg23503501 chr22:45809793 SMC1B;RIBC2 0.64 6.73 0.35 7.75e-11 Tonsillectomy; CRC cis rs17711722 0.565 rs73372653 chr7:65442795 A/T cg07294406 chr7:64700536 NA 0.38 6.06 0.32 3.77e-9 Calcium levels; CRC cis rs7586879 0.639 rs6722022 chr2:25098859 A/G cg22495460 chr2:25135724 ADCY3 -0.85 -15.85 -0.66 1.9e-42 Body mass index; CRC cis rs6545883 0.929 rs6545873 chr2:61733012 T/C cg15711740 chr2:61764176 XPO1 -0.54 -7.47 -0.38 7.19e-13 Tuberculosis; CRC cis rs6479527 0.840 rs2225458 chr9:96756805 A/G cg14459158 chr9:96720562 NA 0.41 7.48 0.38 6.61e-13 Esophageal adenocarcinoma; CRC cis rs4555082 0.645 rs2816605 chr14:105715515 C/T cg13114125 chr14:105738426 BRF1 -0.83 -11.89 -0.55 2.22e-27 Mean platelet volume;Platelet distribution width; CRC cis rs6866344 0.697 rs56159071 chr5:178127246 T/A cg10224037 chr5:178157518 ZNF354A 0.78 11.45 0.53 9.28e-26 Neutrophil percentage of white cells; CRC cis rs7843479 0.930 rs4871903 chr8:21827833 C/T cg17168535 chr8:21777572 XPO7 -0.52 -8.01 -0.4 1.94e-14 Mean corpuscular volume; CRC cis rs4237845 0.611 rs4335583 chr12:58305111 T/C cg02175503 chr12:58329896 NA 0.79 12.42 0.57 2.55e-29 Intelligence (multi-trait analysis); CRC cis rs875971 0.666 rs13242072 chr7:65765988 A/G cg00343986 chr7:65444356 GUSB -0.45 -6.64 -0.34 1.32e-10 Aortic root size; CRC cis rs2404602 0.716 rs8030411 chr15:76699855 A/G cg03037974 chr15:76606532 NA 0.71 12.42 0.56 2.71e-29 Blood metabolite levels; CRC cis rs17227506 0.630 rs67670052 chr8:13443474 G/C cg03566418 chr8:13424080 C8orf48 0.35 6.01 0.31 4.97e-9 Nonsyndromic cleft lip with cleft palate; CRC cis rs10256972 0.706 rs12701970 chr7:1121958 T/C cg04025307 chr7:1156635 C7orf50 0.74 11.98 0.55 1.04e-27 Longevity;Endometriosis; CRC cis rs7605827 0.930 rs9287664 chr2:15597116 A/G cg19274914 chr2:15703543 NA -0.39 -5.99 -0.31 5.51e-9 Educational attainment (years of education); CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg19428682 chr12:42538191 GXYLT1 0.42 6.11 0.32 2.74e-9 Anxiety disorder; CRC cis rs4662945 0.688 rs62174139 chr2:130202775 G/C cg05962382 chr2:130345044 NA -0.33 -5.76 -0.3 1.91e-8 Response to cytidine analogues (gemcitabine); CRC cis rs116095464 0.558 rs6555056 chr5:226222 T/C cg22496380 chr5:211416 CCDC127 -0.85 -9.83 -0.48 3.67e-20 Breast cancer; CRC cis rs7811142 0.943 rs73403312 chr7:100024153 T/C cg00814883 chr7:100076585 TSC22D4 -0.73 -9.37 -0.46 1.17e-18 Platelet count; CRC cis rs9916302 0.904 rs7503705 chr17:37669704 A/G cg03013999 chr17:37608204 MED1 0.45 6.91 0.36 2.6e-11 Glomerular filtration rate (creatinine); CRC cis rs28386778 0.863 rs2727288 chr17:61901197 T/A cg23090583 chr17:61904693 PSMC5;FTSJ3 1.05 20.68 0.75 1.83e-61 Prudent dietary pattern; CRC cis rs9894429 0.608 rs7406219 chr17:79609410 G/T cg21984481 chr17:79567631 NPLOC4 -0.44 -7.6 -0.39 3.18e-13 Eye color traits; CRC cis rs7089973 0.604 rs11196924 chr10:116571796 A/C cg23260525 chr10:116636907 FAM160B1 -0.33 -7.26 -0.37 2.73e-12 Bipolar disorder or attention deficit hyperactivity disorder; CRC cis rs9467711 0.659 rs35555795 chr6:26509382 C/T cg08501292 chr6:25962987 TRIM38 0.88 6.11 0.32 2.84e-9 Autism spectrum disorder or schizophrenia; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg26635366 chr16:30710347 SRCAP 0.45 6.28 0.33 1.1e-9 Anxiety disorder; CRC cis rs9926296 0.565 rs8055825 chr16:89832848 C/T cg21285383 chr16:89894308 SPIRE2 0.34 5.73 0.3 2.25e-8 Vitiligo; CRC cis rs2637266 0.500 rs11001799 chr10:78252554 T/C cg18941641 chr10:78392320 NA -0.35 -5.69 -0.3 2.79e-8 Pulmonary function; CRC cis rs10504229 1.000 rs67630725 chr8:58185580 G/A cg02290350 chr8:58132656 NA -0.42 -5.96 -0.31 6.62e-9 Developmental language disorder (linguistic errors); CRC cis rs7605827 0.930 rs10201564 chr2:15623608 C/G cg19274914 chr2:15703543 NA 0.39 5.95 0.31 6.89e-9 Educational attainment (years of education); CRC cis rs11098499 0.954 rs11098524 chr4:120390032 A/G cg09307838 chr4:120376055 NA 0.66 9.81 0.48 4.12e-20 Corneal astigmatism; CRC cis rs10911251 0.528 rs2333622 chr1:183075456 T/C ch.1.3577855R chr1:183094577 LAMC1 0.86 15.33 0.65 2.18e-40 Colorectal cancer; CRC cis rs5753618 0.561 rs4141404 chr22:31675185 A/C cg22777020 chr22:31556080 RNF185 -0.51 -5.82 -0.31 1.42e-8 Colorectal cancer; CRC cis rs4713118 0.824 rs7759217 chr6:27730463 A/G cg03623178 chr6:28175578 NA 0.69 9.22 0.45 3.71e-18 Parkinson's disease; CRC cis rs1577917 0.771 rs9353318 chr6:86231721 T/A cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A 0.66 8.73 0.43 1.35e-16 Response to antipsychotic treatment; CRC cis rs2404602 0.669 rs1875884 chr15:76638161 C/T cg03037974 chr15:76606532 NA 0.73 12.65 0.57 3.69e-30 Blood metabolite levels; CRC cis rs2688482 0.557 rs3103952 chr3:195522690 T/C cg18918831 chr3:195489782 MUC4 0.66 7.52 0.38 5.25e-13 Lung disease severity in cystic fibrosis; CRC cis rs883565 0.569 rs7637036 chr3:38997778 C/T cg01426195 chr3:39028469 NA -0.42 -7.01 -0.36 1.35e-11 Handedness; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg26222042 chr5:31532200 RNASEN;C5orf22 0.47 6.04 0.32 4.24e-9 Thyroid stimulating hormone; CRC cis rs875971 0.660 rs10215132 chr7:66054406 C/A cg18876405 chr7:65276391 NA -0.61 -11.09 -0.52 1.71e-24 Aortic root size; CRC cis rs4664308 0.935 rs4637057 chr2:160950161 G/T cg03641300 chr2:160917029 PLA2R1 -0.73 -11.83 -0.55 3.66e-27 Idiopathic membranous nephropathy; CRC cis rs17362650 0.653 rs12474647 chr2:9554280 A/T cg12832956 chr2:9616023 IAH1 -0.48 -6.49 -0.34 3.09e-10 Alcohol dependence (age at onset); CRC cis rs35110281 0.744 rs162396 chr21:44947807 T/C cg01579765 chr21:45077557 HSF2BP -0.36 -6.8 -0.35 4.86e-11 Mean corpuscular volume; CRC cis rs6681460 0.966 rs10749765 chr1:67150280 C/T cg02459107 chr1:67143332 SGIP1 0.39 6.93 0.36 2.2e-11 Presence of antiphospholipid antibodies; CRC cis rs6500395 1.000 rs8052073 chr16:48682696 T/C cg04672837 chr16:48644449 N4BP1 0.45 6.63 0.34 1.38e-10 Response to tocilizumab in rheumatoid arthritis; CRC cis rs2576037 0.526 rs3892820 chr18:44479558 A/G cg23996704 chr18:44553084 KATNAL2 -0.33 -6.73 -0.35 7.53e-11 Personality dimensions; CRC cis rs599083 0.590 rs661988 chr11:68189251 T/G cg01657329 chr11:68192670 LRP5 -0.54 -6.55 -0.34 2.16e-10 Bone mineral density (spine); CRC trans rs3733585 0.579 rs4235353 chr4:10122934 C/T cg26043149 chr18:55253948 FECH -0.51 -7.08 -0.36 8.98e-12 Cleft plate (environmental tobacco smoke interaction); CRC cis rs11098499 0.754 rs4107728 chr4:120253910 G/A cg24375607 chr4:120327624 NA 0.47 7.49 0.38 6.26e-13 Corneal astigmatism; CRC cis rs6860806 0.661 rs4705927 chr5:131578608 C/G cg18758796 chr5:131593413 PDLIM4 0.44 8.4 0.42 1.35e-15 Breast cancer; CRC cis rs13191362 1.000 rs35820211 chr6:163046252 C/T cg21926612 chr6:163149169 PACRG;PARK2 0.96 12.13 0.56 3.18e-28 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs11122272 0.701 rs11122273 chr1:231476789 A/G cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.52 -8.02 -0.4 1.89e-14 Hemoglobin concentration; CRC cis rs10540 1.000 rs61876323 chr11:462855 G/A cg21784768 chr11:537496 LRRC56 -0.59 -5.64 -0.3 3.67e-8 Body mass index; CRC trans rs7267979 0.873 rs6132822 chr20:25228695 C/T cg17903999 chr18:56338584 MALT1 -0.41 -6.48 -0.34 3.29e-10 Liver enzyme levels (alkaline phosphatase); CRC cis rs7918232 0.941 rs10741128 chr10:27411509 G/A cg14442939 chr10:27389572 ANKRD26 0.82 9.16 0.45 5.68e-18 Breast cancer; CRC cis rs10504229 0.596 rs7004566 chr8:58115602 G/C cg24829409 chr8:58192753 C8orf71 -0.55 -8.03 -0.4 1.71e-14 Developmental language disorder (linguistic errors); CRC cis rs11971779 0.616 rs11771715 chr7:139027496 T/C cg07862535 chr7:139043722 LUC7L2 0.54 7.05 0.36 1.09e-11 Diisocyanate-induced asthma; CRC cis rs910187 0.571 rs3827049 chr20:45801319 T/A cg27589058 chr20:45804311 EYA2 -0.44 -8.64 -0.43 2.45e-16 Migraine; CRC cis rs13108904 0.539 rs13141992 chr4:1340765 C/T cg00684032 chr4:1343700 KIAA1530 0.61 8.35 0.42 1.93e-15 Obesity-related traits; CRC cis rs2108622 0.727 rs8101038 chr19:15982864 C/T cg13772218 chr19:15982569 NA 0.49 7.01 0.36 1.39e-11 Circulating phylloquinone levels;Vitamin E levels;Acenocoumarol maintenance dosage;Response to Vitamin E supplementation;Metabolite levels;Warfarin maintenance dose; CRC cis rs523522 0.962 rs1050187 chr12:120902111 A/G cg27279351 chr12:120934652 DYNLL1 -0.76 -10.69 -0.51 4.33e-23 High light scatter reticulocyte count; CRC cis rs7666738 0.830 rs4440224 chr4:99044924 G/A cg17366294 chr4:99064904 C4orf37 0.45 7.73 0.39 1.34e-13 Colonoscopy-negative controls vs population controls; CRC cis rs10540 1.000 rs116101630 chr11:506826 G/C cg15790184 chr11:494944 RNH1 0.57 5.8 0.3 1.52e-8 Body mass index; CRC cis rs394563 0.726 rs366905 chr6:149735097 T/A cg16235748 chr6:149772707 ZC3H12D -0.37 -6.75 -0.35 6.74e-11 Dupuytren's disease; CRC cis rs4713118 0.868 rs10484401 chr6:27746590 A/T cg12172441 chr6:28176163 NA -0.57 -6.3 -0.33 9.5e-10 Parkinson's disease; CRC cis rs11233250 0.502 rs17144103 chr11:82403522 C/A cg17391194 chr11:82401662 NA 0.43 6.64 0.34 1.29e-10 Glioblastoma;Glioma; CRC cis rs11229555 0.609 rs11229434 chr11:58185501 C/T cg15696309 chr11:58395628 NA -0.81 -10.31 -0.49 8.83e-22 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; CRC cis rs919433 0.963 rs4850786 chr2:198178608 A/G cg03934865 chr2:198174659 NA 0.43 6.58 0.34 1.87e-10 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC cis rs11098499 0.909 rs11723757 chr4:120299669 C/T cg24375607 chr4:120327624 NA 0.51 7.8 0.39 8.4e-14 Corneal astigmatism; CRC cis rs477692 0.692 rs12265758 chr10:131445144 A/G cg05714579 chr10:131428358 MGMT -0.71 -10.88 -0.51 9.56e-24 Response to temozolomide; CRC trans rs3780486 0.801 rs56687083 chr9:33132134 A/G cg04842962 chr6:43655489 MRPS18A 1.16 25.92 0.82 1.73e-81 IgG glycosylation; CRC cis rs9322193 0.923 rs9800736 chr6:149982417 A/G cg13206674 chr6:150067644 NUP43 0.67 10.1 0.49 4.45e-21 Lung cancer; CRC cis rs853679 0.517 rs9368557 chr6:28131537 T/C cg25164649 chr6:28176230 NA 0.78 9.66 0.47 1.33e-19 Depression; CRC cis rs7954584 0.531 rs11043271 chr12:122394921 A/C cg22618164 chr12:122356400 WDR66 0.37 5.63 0.3 3.93e-8 Mean corpuscular volume; CRC cis rs10504229 1.000 rs17216957 chr8:58179893 C/T cg01721255 chr8:58191610 C8orf71 0.49 6.17 0.32 2e-9 Developmental language disorder (linguistic errors); CRC cis rs10504229 0.636 rs10958525 chr8:58051528 C/A cg11062466 chr8:58055876 NA 0.44 6.02 0.32 4.61e-9 Developmental language disorder (linguistic errors); CRC cis rs9733 0.519 rs12095002 chr1:150649249 G/A cg15448220 chr1:150897856 SETDB1 0.45 6.43 0.33 4.42e-10 Tonsillectomy; CRC trans rs1268083 0.546 rs9398785 chr6:126057748 A/G cg05039488 chr6:79577232 IRAK1BP1 -0.6 -9.56 -0.47 2.76e-19 Migraine; CRC cis rs826838 0.967 rs826858 chr12:39116731 A/G cg26384229 chr12:38710491 ALG10B -0.63 -9.56 -0.47 2.8e-19 Heart rate; CRC cis rs7715806 0.500 rs4703676 chr5:74979866 G/C cg00601450 chr5:74908170 NA 0.45 5.64 0.3 3.73e-8 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs597539 0.652 rs496616 chr11:68672800 G/C cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.89 15.1 0.64 1.63e-39 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs2075371 0.863 rs1646638 chr7:134008706 T/C cg11752832 chr7:134001865 SLC35B4 0.5 7.89 0.4 4.42e-14 Mean platelet volume; CRC cis rs9300255 0.679 rs12829456 chr12:123725395 C/T cg00376283 chr12:123451042 ABCB9 -0.54 -6.08 -0.32 3.26e-9 Neutrophil percentage of white cells; CRC cis rs739496 0.542 rs10849937 chr12:111792427 A/G cg10833066 chr12:111807467 FAM109A 0.54 7.0 0.36 1.46e-11 Platelet count; CRC cis rs4713118 0.513 rs200971 chr6:27858904 C/T cg03623178 chr6:28175578 NA 0.76 10.69 0.51 4.45e-23 Parkinson's disease; CRC cis rs910316 0.967 rs2268619 chr14:75640354 C/G cg03030879 chr14:75389066 RPS6KL1 0.47 6.91 0.36 2.53e-11 Height; CRC cis rs889312 0.500 rs33323 chr5:56175566 C/G cg12311346 chr5:56204834 C5orf35 -0.48 -7.3 -0.37 2.15e-12 Breast cancer;Breast cancer (early onset); CRC cis rs1395 0.744 rs11126931 chr2:27474306 C/T cg14242246 chr2:27434262 C2orf28;SLC5A6 0.32 6.05 0.32 3.9e-9 Blood metabolite levels; CRC cis rs1401999 1.000 rs6443927 chr3:183718864 A/G cg01324343 chr3:183735012 ABCC5 0.8 14.59 0.63 1.54e-37 Anterior chamber depth; CRC cis rs66573146 1.000 rs7686186 chr4:6986094 C/T cg00086871 chr4:6988644 TBC1D14 1.03 7.79 0.39 8.6e-14 Granulocyte percentage of myeloid white cells; CRC cis rs2404602 0.735 rs2436996 chr15:76817420 C/T cg03037974 chr15:76606532 NA -0.5 -7.28 -0.37 2.47e-12 Blood metabolite levels; CRC cis rs2976388 1.000 rs2976394 chr8:143763622 C/T cg22687807 chr8:143858763 LYNX1 -0.37 -6.47 -0.34 3.46e-10 Urinary tract infection frequency; CRC cis rs9814567 1.000 rs9985356 chr3:134232920 C/G cg06109529 chr3:134205091 CEP63;ANAPC13 0.81 11.67 0.54 1.4e-26 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs642803 1.000 rs642803 chr11:65560620 C/T cg27068330 chr11:65405492 SIPA1 0.43 6.05 0.32 3.97e-9 Urate levels; CRC cis rs6951245 1.000 rs76129108 chr7:1089159 G/A cg22907277 chr7:1156413 C7orf50 0.71 7.23 0.37 3.34e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs12479064 0.694 rs11896520 chr2:99995517 C/T cg14399236 chr2:99771627 LIPT1;TSGA10 -0.61 -7.17 -0.37 4.91e-12 Chronic sinus infection; CRC cis rs7917772 0.503 rs11191342 chr10:104344450 G/A cg22532475 chr10:104410764 TRIM8 -0.36 -6.56 -0.34 2.14e-10 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC cis rs7552404 0.924 rs1858536 chr1:76161595 G/T cg22875332 chr1:76189707 ACADM 0.76 11.1 0.52 1.61e-24 Blood metabolite levels;Acylcarnitine levels; CRC cis rs1448094 0.967 rs7312144 chr12:86328256 T/C cg19622623 chr12:86230825 RASSF9 -0.35 -5.69 -0.3 2.8e-8 Major depressive disorder; CRC cis rs17711722 0.565 rs4717276 chr7:65294741 G/T cg18876405 chr7:65276391 NA 0.52 8.65 0.43 2.23e-16 Calcium levels; CRC cis rs2688482 0.557 rs2550236 chr3:195522321 A/G cg18713687 chr3:195489789 MUC4 0.65 7.19 0.37 4.27e-12 Lung disease severity in cystic fibrosis; CRC cis rs7927771 0.524 rs7110300 chr11:47848442 T/G cg20307385 chr11:47447363 PSMC3 0.46 6.64 0.34 1.33e-10 Subjective well-being; CRC cis rs2070488 0.804 rs13059256 chr3:38504315 T/C cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.75 13.13 0.59 5.98e-32 Electrocardiographic conduction measures; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg05141026 chr8:145064874 GRINA 0.41 6.19 0.32 1.75e-9 Liver disease severity in Alagille syndrome; CRC cis rs2976388 0.609 rs2717550 chr8:143787808 T/A cg04969067 chr8:143858791 LYNX1 0.44 7.53 0.38 4.79e-13 Urinary tract infection frequency; CRC cis rs1401999 0.606 rs7644687 chr3:183753353 A/G cg20387954 chr3:183756860 HTR3D 0.46 7.28 0.37 2.55e-12 Anterior chamber depth; CRC cis rs9649213 0.537 rs6971825 chr7:97979548 C/T cg21770322 chr7:97807741 LMTK2 0.53 8.66 0.43 2.22e-16 Prostate cancer (SNP x SNP interaction); CRC cis rs9469890 0.591 rs11754773 chr6:34577257 A/G cg17674042 chr6:34482479 PACSIN1 -0.9 -8.07 -0.41 1.34e-14 Pubertal anthropometrics;Coronary artery disease; CRC cis rs4563143 0.514 rs73029076 chr19:29292032 G/T cg12667521 chr19:29218732 NA 0.53 7.28 0.37 2.45e-12 Methadone dose in opioid dependence; CRC cis rs644799 0.710 rs10765771 chr11:95521044 A/G cg03916912 chr11:95522834 CEP57;FAM76B 0.85 15.78 0.66 3.81e-42 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg07830110 chr22:38794284 LOC400927 0.52 7.44 0.38 8.59e-13 Response to antipsychotic treatment; CRC cis rs1799949 0.965 rs11656945 chr17:41330265 A/G cg23758822 chr17:41437982 NA 0.81 13.61 0.6 9.13e-34 Menopause (age at onset); CRC cis rs12971120 0.891 rs12608037 chr18:72169395 A/G cg26446133 chr18:72167187 CNDP2 -0.76 -11.23 -0.53 5.41e-25 Refractive error; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg26183330 chr7:35577229 NA 0.43 5.96 0.31 6.36e-9 Anxiety disorder; CRC cis rs9322193 0.736 rs10457851 chr6:150096352 T/A cg05861140 chr6:150128134 PCMT1 -0.43 -7.05 -0.36 1.03e-11 Lung cancer; CRC cis rs17023223 0.537 rs2765531 chr1:119585497 A/G cg05756136 chr1:119680316 WARS2 -0.47 -6.33 -0.33 7.91e-10 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for BMI in active individuals; CRC cis rs7712401 0.686 rs185007 chr5:122199318 C/T cg18764291 chr5:122110994 SNX2 0.36 5.74 0.3 2.21e-8 Mean platelet volume; CRC cis rs7945718 0.591 rs7926971 chr11:12698040 A/G cg25843174 chr11:12811716 TEAD1 0.42 7.75 0.39 1.13e-13 Educational attainment (years of education); CRC trans rs7647973 0.710 rs34890793 chr3:49619493 C/T cg21659725 chr3:3221576 CRBN -0.7 -7.78 -0.39 9.74e-14 Menarche (age at onset); CRC cis rs367615 0.704 rs60538082 chr5:108829101 A/G cg17395555 chr5:108820864 NA 0.45 9.21 0.45 4e-18 Colorectal cancer (SNP x SNP interaction); CRC cis rs4746818 1.000 rs10733850 chr10:70959617 C/T cg11621586 chr10:70884670 VPS26A 0.89 7.8 0.4 8.09e-14 Left atrial antero-posterior diameter; CRC cis rs7618915 0.547 rs1561337 chr3:52659963 C/T cg18099408 chr3:52552593 STAB1 -0.43 -7.09 -0.36 8.22e-12 Bipolar disorder; CRC cis rs2721195 0.967 rs1480000 chr8:145702007 C/T cg11211951 chr8:145729740 GPT -0.38 -6.68 -0.35 1.03e-10 Age at first birth; CRC cis rs990171 1.000 rs917996 chr2:103082273 C/A cg03938978 chr2:103052716 IL18RAP 0.46 5.88 0.31 1e-8 Lymphocyte counts; CRC cis rs4237845 0.537 rs59401446 chr12:58259564 G/A cg00677455 chr12:58241039 CTDSP2 0.76 11.49 0.54 6.44e-26 Intelligence (multi-trait analysis); CRC cis rs853679 0.546 rs200948 chr6:27835272 T/C cg23259851 chr6:27775964 HIST1H2AI;HIST1H2BL 0.71 5.93 0.31 7.83e-9 Depression; CRC cis rs9926296 0.585 rs1800337 chr16:89845194 A/G cg21285383 chr16:89894308 SPIRE2 0.36 6.05 0.32 3.97e-9 Vitiligo; CRC cis rs4654899 0.965 rs61779124 chr1:21513306 C/T cg02927042 chr1:21476669 EIF4G3 -0.48 -7.59 -0.39 3.27e-13 Superior frontal gyrus grey matter volume; CRC cis rs4975616 0.869 rs31490 chr5:1344458 G/A cg26373071 chr5:1325741 CLPTM1L 0.49 8.74 0.43 1.17e-16 Lung cancer; CRC cis rs34779708 0.966 rs4934730 chr10:35415555 A/G cg03585969 chr10:35415529 CREM 0.65 8.64 0.43 2.56e-16 Inflammatory bowel disease;Crohn's disease; CRC cis rs4803468 1.000 rs284663 chr19:41932612 C/T cg09537434 chr19:41945824 ATP5SL -0.97 -18.48 -0.71 8.39e-53 Height; CRC cis rs951366 0.789 rs823095 chr1:205679239 G/A cg26354017 chr1:205819088 PM20D1 0.72 10.51 0.5 1.79e-22 Menarche (age at onset); CRC cis rs4638749 0.677 rs12712014 chr2:108812044 A/G cg25838818 chr2:108905173 SULT1C2 0.34 5.66 0.3 3.24e-8 Blood pressure; CRC cis rs4820294 0.669 rs12628135 chr22:38065655 A/G cg11679014 chr22:38092719 TRIOBP -0.27 -5.69 -0.3 2.76e-8 Fat distribution (HIV); CRC cis rs4481887 0.741 rs6587467 chr1:248550976 T/G cg00666640 chr1:248458726 OR2T12 0.4 7.22 0.37 3.67e-12 Common traits (Other); CRC cis rs919433 0.927 rs7592748 chr2:198170688 G/A cg20885578 chr2:198174922 NA -0.45 -7.09 -0.36 8.18e-12 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC cis rs514406 0.505 rs405208 chr1:53176674 C/T cg08859206 chr1:53392774 SCP2 -0.4 -6.05 -0.32 3.87e-9 Monocyte count; CRC cis rs12701220 0.553 rs7782024 chr7:1157502 G/T cg26769984 chr7:1090371 C7orf50 0.55 7.49 0.38 6.44e-13 Bronchopulmonary dysplasia; CRC cis rs11645898 0.935 rs35370634 chr16:72184566 C/T cg14768367 chr16:72042858 DHODH -0.6 -6.74 -0.35 7.24e-11 Blood protein levels; CRC cis rs7737355 0.898 rs4706024 chr5:130904163 G/A cg06307176 chr5:131281290 NA 0.41 5.78 0.3 1.74e-8 Life satisfaction; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg11259409 chr11:1331124 LOC255512;TOLLIP 0.39 6.42 0.33 4.63e-10 Liver disease severity in Alagille syndrome; CRC trans rs7937682 0.883 rs568038 chr11:111432161 A/C cg18187862 chr3:45730750 SACM1L -0.44 -6.19 -0.32 1.78e-9 Primary sclerosing cholangitis; CRC cis rs7811142 1.000 rs67040465 chr7:100083078 G/A cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.06 14.22 0.62 4.03e-36 Platelet count; CRC cis rs59104589 0.569 rs4254498 chr2:242363611 G/C cg19488206 chr2:242435732 STK25 0.49 7.1 0.36 7.78e-12 Fibrinogen levels; CRC cis rs7512552 0.839 rs2867894 chr1:150452912 T/A cg15654264 chr1:150340011 RPRD2 0.59 8.4 0.42 1.39e-15 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); CRC cis rs2732480 0.577 rs2634678 chr12:48735538 C/G cg04545296 chr12:48745243 ZNF641 0.36 6.22 0.32 1.49e-9 Hemoglobin concentration;Red blood cell count;Hematocrit; CRC cis rs66887589 0.616 rs11098497 chr4:120187068 C/T cg09307838 chr4:120376055 NA 0.54 8.32 0.42 2.39e-15 Diastolic blood pressure; CRC cis rs13082711 0.953 rs35124294 chr3:27539526 A/G cg02860705 chr3:27208620 NA 0.58 7.53 0.38 4.97e-13 Systolic blood pressure;Diastolic blood pressure;Blood pressure; CRC cis rs6502050 0.871 rs8066970 chr17:80076051 T/C cg02741985 chr17:80059408 CCDC57 -0.45 -7.43 -0.38 9.53e-13 Life satisfaction; CRC cis rs2952156 0.883 rs1495100 chr17:37832279 C/T cg11212589 chr17:38028394 ZPBP2 0.34 6.1 0.32 2.93e-9 Asthma; CRC cis rs35146811 0.695 rs1623264 chr7:99811204 G/C cg13334819 chr7:99746414 C7orf59 0.52 6.82 0.35 4.46e-11 Coronary artery disease; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg22162010 chr1:113249994 RHOC 0.38 6.93 0.36 2.2e-11 Liver disease severity in Alagille syndrome; CRC cis rs7474896 0.526 rs1208633 chr10:38156873 A/C cg25427524 chr10:38739819 LOC399744 0.66 8.11 0.41 1.03e-14 Obesity (extreme); CRC cis rs8177253 0.665 rs10935074 chr3:133441692 T/G cg11941060 chr3:133502564 NA -0.41 -6.79 -0.35 5.25e-11 Iron status biomarkers; CRC cis rs7487075 0.930 rs11183468 chr12:46806261 A/T cg22049899 chr12:47219821 SLC38A4 0.32 6.44 0.33 4.15e-10 Itch intensity from mosquito bite; CRC cis rs6701037 0.625 rs67332874 chr1:175128537 G/A cg00321850 chr1:175162397 KIAA0040 -0.4 -6.69 -0.35 9.5e-11 Alcohol dependence; CRC cis rs7584330 0.657 rs10211024 chr2:238353776 A/T cg16989719 chr2:238392110 NA -0.49 -9.63 -0.47 1.71e-19 Prostate cancer; CRC cis rs79387448 0.505 rs17027327 chr2:103122513 C/A cg09003973 chr2:102972529 NA 0.68 7.56 0.38 3.99e-13 Gut microbiota (bacterial taxa); CRC cis rs2108622 0.727 rs62106156 chr19:15980424 C/T cg13772218 chr19:15982569 NA 0.48 6.75 0.35 6.63e-11 Circulating phylloquinone levels;Vitamin E levels;Acenocoumarol maintenance dosage;Response to Vitamin E supplementation;Metabolite levels;Warfarin maintenance dose; CRC cis rs9372498 0.505 rs9489493 chr6:118992323 T/C cg18833306 chr6:118973337 C6orf204 0.48 6.81 0.35 4.78e-11 Diastolic blood pressure; CRC cis rs832540 0.552 rs702681 chr5:56218029 C/T cg12311346 chr5:56204834 C5orf35 -0.57 -8.65 -0.43 2.27e-16 Coronary artery disease; CRC cis rs4237845 0.742 rs3751330 chr12:58290226 T/C cg00677455 chr12:58241039 CTDSP2 0.52 7.49 0.38 6.32e-13 Intelligence (multi-trait analysis); CRC cis rs10791323 0.604 rs2853115 chr11:133707908 C/T cg15485101 chr11:133734466 NA -0.41 -7.0 -0.36 1.41e-11 Childhood ear infection; CRC cis rs1691799 0.899 rs1168327 chr12:66728842 G/A cg16791601 chr12:66731901 HELB -0.68 -11.53 -0.54 4.57e-26 White blood cell count (basophil); CRC cis rs2243480 1.000 rs1404147 chr7:65264524 C/T cg18252515 chr7:66147081 NA -1.0 -12.68 -0.57 2.82e-30 Diabetic kidney disease; CRC cis rs17023223 0.537 rs12086686 chr1:119689084 T/A cg05756136 chr1:119680316 WARS2 -0.53 -7.3 -0.37 2.17e-12 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for BMI in active individuals; CRC cis rs7605827 0.930 rs4668912 chr2:15610882 C/T cg19274914 chr2:15703543 NA 0.39 5.9 0.31 8.83e-9 Educational attainment (years of education); CRC cis rs477692 1.000 rs516704 chr10:131419879 G/A cg05714579 chr10:131428358 MGMT 0.52 7.67 0.39 1.99e-13 Response to temozolomide; CRC trans rs11782652 1.000 rs76837345 chr8:82668818 A/G cg26586384 chr17:12526632 NA 0.76 5.98 0.31 5.81e-9 Epithelial ovarian cancer;Ovarian cancer; CRC cis rs941408 0.515 rs1005556 chr19:2778543 G/T cg06609049 chr19:2785107 THOP1 0.95 16.11 0.66 1.8e-43 Total cholesterol levels; CRC cis rs637571 0.522 rs1786175 chr11:65754808 G/A cg17985854 chr11:65770987 BANF1;EIF1AD 0.52 8.75 0.43 1.12e-16 Eosinophil percentage of white cells; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg06978021 chr20:61493312 TCFL5 0.45 6.47 0.34 3.59e-10 Anxiety disorder; CRC cis rs7618915 0.547 rs34173654 chr3:52634605 T/C cg11645453 chr3:52864694 ITIH4 0.36 6.33 0.33 8.26e-10 Bipolar disorder; CRC cis rs6570726 0.935 rs391524 chr6:145823844 A/G cg05347473 chr6:146136440 FBXO30 0.37 6.0 0.31 5.27e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs1865760 1.000 rs3799372 chr6:25922311 A/G cg17691542 chr6:26056736 HIST1H1C 0.56 8.47 0.42 8.18e-16 Height; CRC cis rs17253792 0.545 rs35418987 chr14:56017407 T/G cg01858014 chr14:56050164 KTN1 -0.86 -6.64 -0.34 1.27e-10 Putamen volume; CRC cis rs34779708 0.931 rs68039650 chr10:35385499 C/A cg03585969 chr10:35415529 CREM 0.67 8.87 0.44 4.78e-17 Inflammatory bowel disease;Crohn's disease; CRC cis rs9814567 1.000 rs9884031 chr3:134256500 C/T cg06109529 chr3:134205091 CEP63;ANAPC13 -0.81 -12.3 -0.56 7.56e-29 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs6964587 0.755 rs13229505 chr7:91444679 G/T cg17063962 chr7:91808500 NA 0.67 10.51 0.5 1.88e-22 Breast cancer; CRC cis rs10992471 0.756 rs10123342 chr9:95087824 T/G cg14631576 chr9:95140430 CENPP -0.4 -7.42 -0.38 9.91e-13 Visceral adipose tissue/subcutaneous adipose tissue ratio; CRC trans rs11098499 0.954 rs12510138 chr4:120423935 C/G cg25214090 chr10:38739885 LOC399744 0.64 10.07 0.49 5.96e-21 Corneal astigmatism; CRC cis rs7428 0.527 rs1554110 chr2:85547963 C/T cg24342717 chr2:85555507 TGOLN2 -0.78 -12.69 -0.57 2.61e-30 Ear protrusion; CRC cis rs561341 1.000 rs4795669 chr17:30244701 C/T cg23018236 chr17:30244563 NA -0.63 -7.69 -0.39 1.73e-13 Hip circumference adjusted for BMI; CRC cis rs546131 0.928 rs547504 chr11:34847225 G/T cg11058730 chr11:34937778 PDHX;APIP 0.46 6.7 0.35 8.8e-11 Lung disease severity in cystic fibrosis; CRC cis rs9462846 0.959 rs2235831 chr6:42883911 G/C cg21280719 chr6:42927975 GNMT -0.33 -6.34 -0.33 7.59e-10 Blood protein levels; CRC cis rs1011108 0.518 rs935172 chr2:26804247 A/G cg18742855 chr2:26800399 C2orf70 -0.35 -5.83 -0.31 1.31e-8 Periodontal microbiota; CRC cis rs1707322 0.964 rs785499 chr1:46592420 G/A cg03146154 chr1:46216737 IPP -0.6 -8.09 -0.41 1.18e-14 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs2153535 0.541 rs6905934 chr6:8440043 C/A cg21535247 chr6:8435926 SLC35B3 0.48 7.24 0.37 3.19e-12 Motion sickness; CRC cis rs919433 0.963 rs6738836 chr2:198182432 A/G cg03934865 chr2:198174659 NA -0.43 -6.81 -0.35 4.66e-11 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC cis rs41005 1.000 rs13402078 chr2:8113107 C/T cg03155496 chr2:8117019 LOC339788 -0.38 -6.64 -0.34 1.3e-10 Response to anti-TNF therapy in rheumatoid arthritis; CRC cis rs10484885 0.715 rs2585013 chr6:90553402 T/G cg13799429 chr6:90582589 CASP8AP2 -0.84 -12.61 -0.57 5.05e-30 QRS interval (sulfonylurea treatment interaction); CRC cis rs2153535 0.623 rs6597338 chr6:8533508 A/C cg21535247 chr6:8435926 SLC35B3 0.49 7.47 0.38 7.44e-13 Motion sickness; CRC cis rs3018066 0.867 rs7692652 chr4:107047493 C/T cg01869342 chr4:106983673 TBCK -0.37 -5.88 -0.31 9.89e-9 Cancer; CRC cis rs2721195 0.967 rs1480000 chr8:145702007 C/T cg15320075 chr8:145703422 NA -0.63 -10.38 -0.5 5.15e-22 Age at first birth; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg22834172 chr17:37774349 NA 0.49 6.33 0.33 8.24e-10 Thyroid stimulating hormone; CRC cis rs372883 0.613 rs1153274 chr21:30660026 T/C cg24692254 chr21:30365293 RNF160 -0.63 -9.41 -0.46 8.77e-19 Pancreatic cancer; CRC cis rs950027 0.620 rs1153857 chr15:45659095 G/T cg21132104 chr15:45694354 SPATA5L1 0.41 5.96 0.31 6.57e-9 Response to fenofibrate (adiponectin levels); CRC cis rs4665809 1.000 rs4665309 chr2:26335502 T/C cg27170947 chr2:26402098 FAM59B -0.46 -6.1 -0.32 2.93e-9 Gut microbiome composition (summer); CRC cis rs6691722 0.506 rs1016209 chr1:24745615 A/G cg18323236 chr1:24743029 NIPAL3 -0.48 -7.44 -0.38 8.71e-13 Response to interferon beta in multiple sclerosis; CRC cis rs7178572 0.568 rs1823100 chr15:77402744 C/T cg22256960 chr15:77711686 NA -0.64 -8.96 -0.44 2.48e-17 Type 2 diabetes; CRC cis rs9435341 1.000 rs9435341 chr1:107616641 T/C cg14828511 chr1:107599125 PRMT6 -0.45 -6.5 -0.34 2.99e-10 Facial morphology (factor 21, depth of nasal alae); CRC cis rs2836633 0.929 rs2836602 chr21:40039169 A/T cg12884169 chr21:40033163 ERG -0.43 -9.84 -0.48 3.31e-20 Coronary artery disease; CRC cis rs988712 0.622 rs2030323 chr11:27728539 A/C cg10635145 chr11:27742435 BDNF 0.41 6.23 0.32 1.42e-9 Obesity; CRC trans rs944990 0.595 rs10123378 chr9:96375217 C/T cg17023971 chr6:2415850 NA -0.4 -6.07 -0.32 3.51e-9 Body mass index; CRC cis rs3806843 1.000 rs10223116 chr5:140192643 C/T cg19875535 chr5:140030758 IK 0.54 8.65 0.43 2.28e-16 Depressive symptoms (multi-trait analysis); CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg23713156 chr17:80606235 WDR45L -0.44 -6.46 -0.34 3.73e-10 Myopia (pathological); CRC cis rs2239547 0.603 rs12489490 chr3:53064022 C/A cg18404041 chr3:52824283 ITIH1 -0.38 -6.38 -0.33 5.92e-10 Schizophrenia; CRC cis rs4819052 0.851 rs9974628 chr21:46672647 C/T cg11663144 chr21:46675770 NA -0.85 -15.04 -0.64 2.95e-39 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg07256006 chr1:156182774 PMF1 0.53 7.55 0.38 4.18e-13 Response to antipsychotic treatment; CRC cis rs6540559 0.546 rs59435160 chr1:210030730 C/A cg22029157 chr1:209979665 IRF6 0.64 8.11 0.41 1.05e-14 Cleft lip with or without cleft palate; CRC cis rs1953600 0.668 rs3122586 chr10:81950326 C/T cg27417294 chr10:81904244 PLAC9 -0.37 -5.82 -0.31 1.42e-8 Sarcoidosis; CRC cis rs1799949 1.000 rs1060915 chr17:41234470 A/G cg23758822 chr17:41437982 NA 0.82 13.6 0.6 9.9e-34 Menopause (age at onset); CRC cis rs2976388 1.000 rs2920295 chr8:143764937 A/G cg05569086 chr8:143859399 LYNX1 -0.33 -5.8 -0.3 1.55e-8 Urinary tract infection frequency; CRC cis rs1728785 1.000 rs11648314 chr16:68596775 A/G cg02972257 chr16:68554789 NA -0.66 -7.85 -0.4 6.01e-14 Ulcerative colitis; CRC cis rs17713451 0.635 rs113032029 chr7:151270211 G/A cg18404559 chr7:151322523 PRKAG2 -0.57 -6.42 -0.33 4.66e-10 Interleukin-4 levels; CRC cis rs7208859 0.573 rs8078182 chr17:29149664 C/T cg14008862 chr17:28927542 LRRC37B2 0.54 6.31 0.33 9.25e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs3857067 0.934 rs899132 chr4:95040022 A/C cg11021082 chr4:95130006 SMARCAD1 0.38 5.7 0.3 2.68e-8 QT interval; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg12801072 chr3:5229809 EDEM1 0.38 6.07 0.32 3.61e-9 Intelligence (multi-trait analysis); CRC cis rs2404602 0.716 rs2404737 chr15:76872217 T/G cg03037974 chr15:76606532 NA 0.69 12.16 0.56 2.47e-28 Blood metabolite levels; CRC cis rs4972806 0.776 rs2072589 chr2:177042871 C/T cg14324370 chr2:177042789 NA 0.8 13.4 0.59 5.87e-33 IgG glycosylation; CRC cis rs10256972 0.933 rs35696159 chr7:1047194 A/G cg03923535 chr7:1197113 ZFAND2A 0.43 5.85 0.31 1.18e-8 Longevity;Endometriosis; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg03105770 chr11:82997414 CCDC90B 0.44 5.98 0.31 5.92e-9 Anxiety disorder; CRC cis rs11792861 0.888 rs57314245 chr9:111813832 G/A cg14432460 chr9:111696404 IKBKAP;C9orf6 0.43 5.72 0.3 2.43e-8 Menarche (age at onset); CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg18491775 chr10:76586186 MYST4 0.56 7.63 0.39 2.49e-13 Thyroid stimulating hormone; CRC cis rs1005277 0.579 rs2474568 chr10:38383147 A/T cg25427524 chr10:38739819 LOC399744 -0.76 -13.55 -0.6 1.52e-33 Extrinsic epigenetic age acceleration; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg04219625 chr11:66247798 DPP3 0.41 6.14 0.32 2.35e-9 Intelligence (multi-trait analysis); CRC cis rs611744 0.550 rs57045491 chr8:109279120 A/C cg18478394 chr8:109455254 TTC35 0.38 5.89 0.31 9.79e-9 Dupuytren's disease; CRC cis rs35306767 0.671 rs11253473 chr10:906826 A/G cg20503657 chr10:835505 NA 0.92 11.77 0.54 6.17e-27 Eosinophil percentage of granulocytes; CRC cis rs4713118 0.513 rs149944 chr6:28002818 C/T cg20615401 chr6:28092323 ZSCAN16 0.46 6.26 0.33 1.18e-9 Parkinson's disease; CRC cis rs28386778 0.897 rs2665795 chr17:61925272 A/G cg06873352 chr17:61820015 STRADA -0.74 -13.96 -0.61 4.29e-35 Prudent dietary pattern; CRC cis rs2708240 0.666 rs2710121 chr7:147608448 C/T cg02373104 chr7:147601429 MIR548F3;CNTNAP2 -0.4 -5.88 -0.31 1.01e-8 QT interval (drug interaction); CRC cis rs2073300 0.609 rs3827086 chr20:23357331 C/T cg12062639 chr20:23401060 NAPB 0.69 6.25 0.33 1.28e-9 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs7771547 0.542 rs597153 chr6:36395997 C/T cg04289385 chr6:36355825 ETV7 0.39 5.71 0.3 2.48e-8 Platelet distribution width; CRC cis rs713477 0.967 rs6573031 chr14:55913763 C/G cg13175173 chr14:55914753 NA -0.52 -9.9 -0.48 2.06e-20 Pediatric bone mineral content (femoral neck); CRC cis rs12692738 0.526 rs650330 chr2:165624861 G/A cg03182029 chr2:165697222 COBLL1 0.5 5.86 0.31 1.11e-8 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);Waist-to-hip ratio adjusted for BMI in non-smokers;Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction);Waist-to-hip ratio adjusted for body mass index; CRC cis rs6860806 0.507 rs272892 chr5:131664349 C/T cg27615366 chr5:131592974 PDLIM4 0.32 5.69 0.3 2.79e-8 Breast cancer; CRC cis rs1799949 0.965 rs11656945 chr17:41330265 A/G cg19454999 chr17:41278357 BRCA1;NBR2 0.54 8.25 0.41 3.98e-15 Menopause (age at onset); CRC cis rs870825 0.929 rs72689255 chr4:185590141 T/C cg07424746 chr4:185654737 MLF1IP -0.63 -5.98 -0.31 5.66e-9 Blood protein levels; CRC cis rs11212617 0.935 rs4623864 chr11:108051300 A/G cg01991180 chr11:108092276 ATM;NPAT 0.41 6.1 0.32 2.97e-9 Response to metformin in type 2 diabetes (glycemic); CRC cis rs17767392 0.918 rs72728427 chr14:71769989 T/C cg13720639 chr14:72061746 SIPA1L1 -0.53 -6.86 -0.35 3.45e-11 Mitral valve prolapse; CRC cis rs66573146 1.000 rs55833486 chr4:6978729 C/A cg00086871 chr4:6988644 TBC1D14 1.01 8.57 0.43 4.18e-16 Granulocyte percentage of myeloid white cells; CRC cis rs9875589 0.509 rs6778884 chr3:14044681 A/G cg14375111 chr3:14165186 TMEM43;CHCHD4 0.38 5.9 0.31 9.22e-9 Ovarian reserve; CRC cis rs6693567 0.565 rs1260374 chr1:150331593 G/A cg15654264 chr1:150340011 RPRD2 0.42 6.22 0.32 1.55e-9 Migraine; CRC cis rs6838801 0.892 rs28568554 chr4:77576016 T/G cg17476223 chr4:77663285 SHROOM3 0.42 5.9 0.31 9.22e-9 Cleft lip with or without cleft palate; CRC cis rs853679 0.517 rs9348796 chr6:28126202 A/G cg02631126 chr6:28058918 ZSCAN12L1 0.29 5.91 0.31 8.38e-9 Depression; CRC cis rs9814567 1.000 rs7426847 chr3:134267519 A/G cg06109529 chr3:134205091 CEP63;ANAPC13 0.82 12.06 0.55 5.69e-28 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs2979489 0.945 rs2979472 chr8:30291704 G/C cg26383811 chr8:30366931 RBPMS 0.69 9.45 0.46 6.43e-19 Mean corpuscular hemoglobin;Plateletcrit;Neutrophil count;Granulocyte count;Sum basophil neutrophil counts;Mean corpuscular volume;Myeloid white cell count;Sum neutrophil eosinophil counts; CRC cis rs2732480 0.557 rs2634682 chr12:48732943 T/C cg04545296 chr12:48745243 ZNF641 0.36 6.18 0.32 1.88e-9 Hemoglobin concentration;Red blood cell count;Hematocrit; CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg06058923 chr6:80488001 NA 0.44 6.97 0.36 1.78e-11 Obesity-related traits; CRC cis rs9329221 0.736 rs12548025 chr8:10260921 A/T cg27411982 chr8:10470053 RP1L1 0.36 5.65 0.3 3.46e-8 Neuroticism; CRC cis rs5758659 0.714 rs133376 chr22:42466905 C/T cg25452165 chr22:42524984 CYP2D6 0.42 5.92 0.31 8.25e-9 Cognitive function; CRC trans rs7267979 1.000 rs2297497 chr20:25297909 C/T cg17903999 chr18:56338584 MALT1 0.41 6.76 0.35 6.22e-11 Liver enzyme levels (alkaline phosphatase); CRC cis rs7772486 0.840 rs2777478 chr6:146309117 T/C cg13319975 chr6:146136371 FBXO30 -0.39 -5.87 -0.31 1.08e-8 Lobe attachment (rater-scored or self-reported); CRC cis rs9611565 0.546 rs5758431 chr22:42109917 A/G cg03806693 chr22:41940476 POLR3H 1.0 12.85 0.58 6.4e-31 Vitiligo; CRC cis rs4319547 1.000 rs6489071 chr12:123025576 C/G cg05707623 chr12:122985044 ZCCHC8 -0.75 -9.73 -0.47 8.05e-20 Body mass index; CRC cis rs898097 0.625 rs2125479 chr17:80890262 A/G cg15664640 chr17:80829946 TBCD -0.46 -7.22 -0.37 3.68e-12 Breast cancer; CRC cis rs10760158 0.739 rs10760163 chr9:124008452 C/A cg14417974 chr9:124058376 GSN -0.33 -5.6 -0.3 4.46e-8 Pulse pressure; CRC cis rs881375 0.867 rs10818484 chr9:123661194 C/T cg09586646 chr9:123605570 PSMD5;LOC253039 0.52 7.15 0.37 5.83e-12 Rheumatoid arthritis; CRC cis rs9322193 0.923 rs11155670 chr6:149966128 C/G cg00933542 chr6:150070202 PCMT1 0.31 6.21 0.32 1.57e-9 Lung cancer; CRC cis rs10479542 0.784 rs7703730 chr5:178986632 C/A cg05457628 chr5:178986728 RUFY1 -0.35 -5.9 -0.31 8.84e-9 Lung cancer; CRC cis rs6543140 0.964 rs62154972 chr2:103048738 G/A cg03938978 chr2:103052716 IL18RAP 0.47 7.25 0.37 3.04e-12 Blood protein levels; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg03306564 chr11:64902099 SYVN1 0.48 6.68 0.35 1.02e-10 Response to antipsychotic treatment; CRC trans rs1973993 0.967 rs2181375 chr1:96940119 A/G cg10631902 chr5:14652156 NA 0.47 8.38 0.42 1.61e-15 Weight; CRC cis rs483180 0.531 rs662243 chr1:120209564 A/C cg19096424 chr1:120255104 PHGDH 0.42 5.98 0.31 5.71e-9 Macular telangiectasia type 2; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg19769827 chr1:203259772 NA 0.4 6.12 0.32 2.59e-9 Intelligence (multi-trait analysis); CRC cis rs13256369 1.000 rs10088439 chr8:8576699 T/G cg17143192 chr8:8559678 CLDN23 0.47 6.08 0.32 3.37e-9 Obesity-related traits; CRC cis rs6912958 0.559 rs376633 chr6:88042785 T/C cg04972856 chr6:88032051 C6orf162;GJB7 0.32 6.05 0.32 3.87e-9 Monocyte percentage of white cells; CRC cis rs10504229 0.600 rs6987243 chr8:58115406 T/C cg04204079 chr8:58130323 NA -0.45 -5.78 -0.3 1.71e-8 Developmental language disorder (linguistic errors); CRC cis rs6540556 0.769 rs10157973 chr1:209924425 C/T cg23920097 chr1:209922102 NA -0.54 -6.65 -0.34 1.22e-10 Red blood cell count; CRC cis rs2243480 1.000 rs6959002 chr7:65650496 A/G cg12463550 chr7:65579703 CRCP -0.71 -6.52 -0.34 2.61e-10 Diabetic kidney disease; CRC cis rs1577917 0.876 rs1582126 chr6:86697205 C/A cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.56 -6.99 -0.36 1.51e-11 Response to antipsychotic treatment; CRC cis rs2652834 0.904 rs34786874 chr15:63397504 A/G cg05507819 chr15:63340323 TPM1 0.46 6.05 0.32 3.88e-9 HDL cholesterol; CRC cis rs875971 0.965 rs28682868 chr7:65689809 C/T cg11764359 chr7:65958608 NA -0.62 -9.98 -0.48 1.2e-20 Aortic root size; CRC cis rs853679 0.517 rs9468286 chr6:28079428 C/T cg12172441 chr6:28176163 NA 0.62 7.27 0.37 2.56e-12 Depression; CRC cis rs7412746 0.658 rs2275235 chr1:150730279 A/G cg15448220 chr1:150897856 SETDB1 0.54 7.59 0.39 3.39e-13 Melanoma; CRC trans rs17607347 0.738 rs1297137 chr16:72412385 T/C cg27230510 chr3:50404023 CACNA2D2 -0.54 -6.05 -0.32 4e-9 Intelligence (multi-trait analysis); CRC cis rs2814982 0.514 rs73405691 chr6:34468767 A/G cg14254433 chr6:34482411 PACSIN1 -0.57 -6.53 -0.34 2.44e-10 Cholesterol, total;Total cholesterol levels; CRC cis rs12887734 0.524 rs722637 chr14:104261723 G/T cg01849466 chr14:104193079 ZFYVE21 0.48 7.66 0.39 2.13e-13 Schizophrenia;Autism spectrum disorder or schizophrenia; CRC cis rs2276314 0.857 rs28375959 chr18:33601534 T/G cg05985134 chr18:33552581 C18orf21 0.49 6.38 0.33 6.15e-10 Endometriosis;Drug-induced torsades de pointes; CRC cis rs11098699 0.784 rs11947137 chr4:124205966 C/G cg09941581 chr4:124220074 SPATA5 0.4 5.87 0.31 1.08e-8 Mosquito bite size; CRC trans rs61931739 0.534 rs1352207 chr12:34036862 C/T cg26384229 chr12:38710491 ALG10B -0.46 -6.34 -0.33 7.52e-10 Morning vs. evening chronotype; CRC cis rs7918232 0.941 rs4749228 chr10:27433618 C/T cg14240646 chr10:27532245 ACBD5 0.81 9.18 0.45 4.9e-18 Breast cancer; CRC cis rs2493151 1.000 rs2478542 chr1:230879511 T/C cg07502417 chr1:230849801 AGT 0.28 5.65 0.3 3.4e-8 Blood protein levels; CRC cis rs28386778 0.897 rs2727295 chr17:61887693 C/T cg06873352 chr17:61820015 STRADA 0.66 12.09 0.55 4.32e-28 Prudent dietary pattern; CRC cis rs6952808 0.929 rs34145223 chr7:1926237 G/A cg02951883 chr7:2050386 MAD1L1 -0.72 -11.69 -0.54 1.22e-26 Bipolar disorder and schizophrenia; CRC cis rs243505 0.737 rs243513 chr7:148429806 G/A cg09806900 chr7:148480153 CUL1 -0.53 -6.68 -0.35 1.03e-10 Inflammatory bowel disease;Crohn's disease; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg06620762 chr15:76136437 UBE2Q2 0.47 6.74 0.35 7.06e-11 Response to antipsychotic treatment; CRC cis rs2224391 1.000 rs2753248 chr6:5262154 G/T cg09085698 chr6:5261316 LYRM4;FARS2 -0.44 -5.71 -0.3 2.51e-8 Height; CRC cis rs1580019 0.844 rs1584615 chr7:32503258 G/C cg06627557 chr7:32535165 LSM5;AVL9 0.85 13.48 0.6 2.83e-33 Cognitive ability; CRC cis rs9487051 0.676 rs6929438 chr6:109595506 C/T cg21918786 chr6:109611834 NA -0.4 -7.02 -0.36 1.29e-11 Reticulocyte fraction of red cells; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg23260255 chr3:187871479 LPP 0.46 6.52 0.34 2.7e-10 Response to antipsychotic treatment; CRC cis rs1018836 0.892 rs13267237 chr8:91550820 T/C cg16814680 chr8:91681699 NA -0.65 -10.46 -0.5 2.63e-22 Ejection fraction in Tripanosoma cruzi seropositivity; CRC cis rs2354432 0.607 rs6593751 chr1:146726023 A/G cg25205988 chr1:146714368 CHD1L -1.17 -9.73 -0.47 7.81e-20 Mitochondrial DNA levels; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg23365832 chr22:26986032 TPST2 0.44 6.11 0.32 2.84e-9 Anxiety disorder; CRC cis rs1862618 0.853 rs3099459 chr5:56137170 G/C cg18230493 chr5:56204884 C5orf35 -0.72 -9.16 -0.45 5.73e-18 Initial pursuit acceleration; CRC cis rs4820294 0.669 rs12628135 chr22:38065655 A/G cg21798802 chr22:38057573 PDXP 0.37 6.24 0.33 1.35e-9 Fat distribution (HIV); CRC cis rs7727544 0.716 rs10058655 chr5:131570896 A/T cg09877947 chr5:131593287 PDLIM4 0.36 6.46 0.34 3.74e-10 Blood metabolite levels; CRC trans rs11343 0.675 rs7359333 chr16:19262344 A/T cg08460590 chr17:7495881 FXR2 -0.45 -6.04 -0.32 4.23e-9 Parkinson's disease; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg11208039 chr11:19138753 ZDHHC13 0.43 6.01 0.31 4.8e-9 Response to antipsychotic treatment; CRC cis rs10046574 0.831 rs7797208 chr7:135137729 C/T cg27474649 chr7:135195673 CNOT4 0.69 5.71 0.3 2.49e-8 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs4474465 1.000 rs10899506 chr11:78168705 C/T cg27205649 chr11:78285834 NARS2 -0.48 -5.85 -0.31 1.18e-8 Alzheimer's disease (survival time); CRC cis rs806215 1.000 rs712698 chr7:127249098 C/T cg25922125 chr7:127225783 GCC1 0.58 6.37 0.33 6.52e-10 Type 2 diabetes; CRC cis rs10464366 0.957 rs6979210 chr7:39104119 C/G cg18850127 chr7:39170497 POU6F2 0.5 6.43 0.33 4.42e-10 IgG glycosylation; CRC cis rs2228479 0.850 rs11649162 chr16:89807131 C/A cg19635926 chr16:89946313 TCF25 0.66 5.98 0.31 5.71e-9 Skin colour saturation; CRC cis rs6424115 0.800 rs4649123 chr1:24197696 A/G cg15997130 chr1:24165203 NA 0.72 10.69 0.51 4.31e-23 Immature fraction of reticulocytes; CRC cis rs2952156 1.000 rs1565923 chr17:37858678 A/G cg11212589 chr17:38028394 ZPBP2 0.37 6.28 0.33 1.06e-9 Asthma; CRC trans rs9291683 0.609 rs55959894 chr4:10026580 G/A cg26043149 chr18:55253948 FECH 0.51 7.92 0.4 3.78e-14 Bone mineral density; CRC cis rs13098911 0.540 rs9845382 chr3:46111759 C/T cg12691230 chr3:46064611 XCR1 -0.52 -6.11 -0.32 2.89e-9 Celiac disease; CRC cis rs9916302 0.706 rs9646419 chr17:37597185 A/G cg00129232 chr17:37814104 STARD3 -0.58 -7.18 -0.37 4.56e-12 Glomerular filtration rate (creatinine); CRC cis rs3858526 0.628 rs1840177 chr11:5944627 T/G cg26762873 chr11:5879799 OR52E8 0.4 6.51 0.34 2.77e-10 DNA methylation (variation); CRC cis rs1552244 0.554 rs3732963 chr3:10048885 G/T cg00166722 chr3:10149974 C3orf24 0.43 6.37 0.33 6.36e-10 Alzheimer's disease; CRC cis rs76878669 0.561 rs6591215 chr11:66170611 A/C cg24851651 chr11:66362959 CCS 0.37 6.37 0.33 6.38e-10 Educational attainment (years of education); CRC cis rs10540 0.818 rs12806089 chr11:501468 G/A cg21784768 chr11:537496 LRRC56 -0.69 -6.56 -0.34 2.11e-10 Body mass index; CRC cis rs6504950 0.830 rs17745231 chr17:53036529 C/G cg26251398 chr17:52985966 TOM1L1 0.42 5.62 0.3 4.01e-8 Breast cancer; CRC cis rs2070997 0.938 rs3808817 chr9:133746060 C/T cg01000188 chr9:133769184 QRFP 0.58 6.73 0.35 7.74e-11 Response to amphetamines; CRC cis rs17713451 0.593 rs80311488 chr7:151279117 G/A cg18404559 chr7:151322523 PRKAG2 -0.54 -6.27 -0.33 1.11e-9 Interleukin-4 levels; CRC cis rs4594175 0.926 rs10138269 chr14:51615360 T/C cg23942311 chr14:51606299 NA 0.67 11.24 0.53 4.9e-25 Cancer; CRC cis rs7727544 0.735 rs274559 chr5:131720070 A/G cg09877947 chr5:131593287 PDLIM4 -0.32 -5.68 -0.3 3.04e-8 Blood metabolite levels; CRC cis rs6426558 0.514 rs3754418 chr1:227348473 T/C cg10327440 chr1:227177885 CDC42BPA -0.43 -6.35 -0.33 7.16e-10 Neutrophil percentage of white cells; CRC cis rs1799949 0.965 rs799916 chr17:41243190 G/T cg25072359 chr17:41440525 NA -0.53 -8.48 -0.42 7.79e-16 Menopause (age at onset); CRC trans rs3733585 0.726 rs4306953 chr4:9955776 G/A cg26043149 chr18:55253948 FECH -0.5 -7.78 -0.39 9.21e-14 Cleft plate (environmental tobacco smoke interaction); CRC cis rs7937682 0.883 rs517982 chr11:111462687 T/C cg09085632 chr11:111637200 PPP2R1B -0.97 -18.57 -0.72 3.67e-53 Primary sclerosing cholangitis; CRC cis rs28386778 0.863 rs58269663 chr17:61843130 G/A cg11494091 chr17:61959527 GH2 0.63 10.73 0.51 3.01e-23 Prudent dietary pattern; CRC cis rs1799949 1.000 rs12944430 chr17:41330820 C/G cg23758822 chr17:41437982 NA 0.81 13.61 0.6 9.13e-34 Menopause (age at onset); CRC cis rs9430161 0.644 rs34365965 chr1:11034442 G/A cg02454025 chr1:11042201 C1orf127 0.97 16.17 0.67 1.12e-43 Ewing sarcoma; CRC cis rs28386778 0.897 rs1062787 chr17:61896004 T/C cg22520471 chr17:61851767 DDX42;CCDC47 0.76 11.71 0.54 1.01e-26 Prudent dietary pattern; CRC trans rs3780486 0.846 rs7036812 chr9:33143822 T/C cg04842962 chr6:43655489 MRPS18A 1.17 24.03 0.8 2.24e-74 IgG glycosylation; CRC cis rs8072100 1.000 rs8065669 chr17:45724996 G/A cg08085267 chr17:45401833 C17orf57 -0.66 -10.77 -0.51 2.23e-23 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC trans rs1455244 0.700 rs7229302 chr18:11508904 G/T cg06536750 chr1:6846042 CAMTA1 0.41 6.27 0.33 1.12e-9 Schizophrenia; CRC cis rs7725052 0.609 rs6451507 chr5:40458688 G/A cg09067459 chr5:40385259 NA -0.4 -6.57 -0.34 1.94e-10 Pediatric autoimmune diseases; CRC cis rs7617773 0.779 rs3731487 chr3:48229624 C/T cg11946769 chr3:48343235 NME6 0.71 9.59 0.47 2.25e-19 Coronary artery disease; CRC cis rs6500602 0.627 rs2270363 chr16:4526292 A/G cg14951292 chr16:4525986 HMOX2;NMRAL1 0.75 10.45 0.5 2.84e-22 Schizophrenia; CRC cis rs10504229 0.569 rs75466737 chr8:58055034 A/G cg20607798 chr8:58055168 NA 0.55 6.15 0.32 2.26e-9 Developmental language disorder (linguistic errors); CRC cis rs1448094 0.512 rs61930862 chr12:86246567 A/G cg18827107 chr12:86230957 RASSF9 -0.45 -7.49 -0.38 6.6e-13 Major depressive disorder; CRC cis rs3750082 0.621 rs7778110 chr7:32949001 C/T cg05721444 chr7:32995514 FKBP9 0.48 6.21 0.32 1.62e-9 Glomerular filtration rate (creatinine); CRC trans rs11148252 0.846 rs8001624 chr13:53002995 T/C cg18335740 chr13:41363409 SLC25A15 0.54 8.26 0.41 3.51e-15 Lewy body disease; CRC cis rs9300255 0.722 rs10773008 chr12:123800820 A/G cg00376283 chr12:123451042 ABCB9 0.54 7.19 0.37 4.4e-12 Neutrophil percentage of white cells; CRC cis rs2739330 0.796 rs5760106 chr22:24250645 A/C cg16132339 chr22:24313637 DDTL;DDT -0.58 -9.03 -0.45 1.51e-17 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs7811142 1.000 rs7811142 chr7:100065443 A/T cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.99 13.68 0.6 4.96e-34 Platelet count; CRC cis rs4713118 0.715 rs200480 chr6:27773664 A/G cg12273811 chr6:28175739 NA 0.45 6.4 0.33 5.4e-10 Parkinson's disease; CRC cis rs1059312 0.808 rs10847694 chr12:129292457 C/A cg09035930 chr12:129282057 SLC15A4 0.52 8.8 0.44 8.05e-17 Systemic lupus erythematosus; CRC cis rs9527 0.615 rs10883800 chr10:104671212 A/C cg15744005 chr10:104629667 AS3MT -0.3 -6.1 -0.32 3.02e-9 Arsenic metabolism; CRC cis rs1707322 0.721 rs10157795 chr1:46228192 G/A cg06784218 chr1:46089804 CCDC17 0.56 10.29 0.49 1.01e-21 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg08165151 chr6:88411075 NCRNA00120;AKIRIN2 0.47 5.98 0.31 5.94e-9 Thyroid stimulating hormone; CRC cis rs7113874 0.589 rs7949017 chr11:8492127 C/T cg17679104 chr11:8615758 STK33 0.35 5.74 0.3 2.17e-8 Body mass index in physically active individuals;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs7824557 0.583 rs2263511 chr8:11233318 A/C cg20542592 chr8:11973495 FAM66D 0.36 6.21 0.32 1.63e-9 Retinal vascular caliber; CRC cis rs2836974 0.544 rs8128919 chr21:40711862 C/T cg11890956 chr21:40555474 PSMG1 0.67 9.88 0.48 2.44e-20 Cognitive function; CRC cis rs637571 0.522 rs12797319 chr11:65735672 G/A cg17985854 chr11:65770987 BANF1;EIF1AD 0.54 8.71 0.43 1.47e-16 Eosinophil percentage of white cells; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg05013483 chr15:72978625 HIGD2B;BBS4 0.45 6.0 0.31 5.29e-9 Anxiety disorder; CRC cis rs12282928 1.000 rs10769336 chr11:48292339 T/C cg20307385 chr11:47447363 PSMC3 -0.49 -6.03 -0.32 4.47e-9 Migraine - clinic-based; CRC trans rs916888 0.821 rs199514 chr17:44856881 G/A cg22968622 chr17:43663579 NA -1.2 -15.29 -0.64 2.89e-40 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC trans rs13046373 0.905 rs4816372 chr21:32077414 A/T cg12302830 chr20:33297742 TP53INP2 -0.41 -6.12 -0.32 2.69e-9 HDL cholesterol; CRC cis rs9891119 0.550 rs7219059 chr17:40521670 T/C cg06270615 chr17:40516068 STAT3 -0.31 -6.1 -0.32 3.04e-9 Multiple sclerosis;Crohn's disease; CRC cis rs2180341 1.000 rs9398838 chr6:127635285 C/T cg27446573 chr6:127587934 RNF146 0.98 14.44 0.62 6.21e-37 Breast cancer; CRC trans rs11764590 0.694 rs6972969 chr7:2099331 A/G cg11693508 chr17:37793320 STARD3 0.48 6.44 0.33 4.14e-10 Neuroticism; CRC trans rs3733585 0.725 rs6449201 chr4:9973894 C/T cg26043149 chr18:55253948 FECH -0.5 -7.57 -0.39 3.73e-13 Cleft plate (environmental tobacco smoke interaction); CRC cis rs1218582 0.772 rs12095061 chr1:154912968 A/T cg24250549 chr1:154909240 PMVK 0.64 10.86 0.51 1.07e-23 Prostate cancer; CRC cis rs6502050 0.835 rs6502077 chr17:80122966 G/C cg09264619 chr17:80180166 NA -0.35 -5.93 -0.31 7.47e-9 Life satisfaction; CRC cis rs9287719 0.967 rs12995159 chr2:10753323 C/T cg00105475 chr2:10696890 NA 0.45 7.17 0.37 4.85e-12 Prostate cancer; CRC trans rs7726839 0.540 rs74553517 chr5:665671 C/T cg25482853 chr8:67687455 SGK3 1.16 13.2 0.59 3.15e-32 Obesity-related traits; CRC cis rs4665809 1.000 rs6546767 chr2:26328746 A/G cg04944784 chr2:26401820 FAM59B -0.6 -7.57 -0.39 3.84e-13 Gut microbiome composition (summer); CRC cis rs798554 0.959 rs798557 chr7:2758982 G/A cg14895029 chr7:2775587 GNA12 -0.42 -6.17 -0.32 1.99e-9 Height; CRC cis rs853679 0.628 rs9368560 chr6:28159960 T/C cg15786705 chr6:28176104 NA 0.79 10.76 0.51 2.44e-23 Depression; CRC cis rs12142240 0.738 rs41293275 chr1:46806429 A/T cg00530320 chr1:46809349 NSUN4 0.58 7.84 0.4 6.26e-14 Menopause (age at onset); CRC cis rs12134245 0.776 rs13447526 chr1:91983174 A/G cg21854759 chr1:92012499 NA 0.48 7.36 0.38 1.46e-12 Breast cancer; CRC cis rs9427116 0.702 rs9427109 chr1:154609009 A/G cg17218026 chr1:154582156 ADAR 0.63 10.22 0.49 1.74e-21 Blood protein levels; CRC cis rs4975709 0.589 rs4975745 chr5:1861058 G/C cg12288994 chr5:1860383 NA 0.39 6.93 0.36 2.17e-11 Cardiovascular disease risk factors; CRC cis rs1552244 0.938 rs7647987 chr3:10140696 A/G cg08888203 chr3:10149979 C3orf24 0.67 9.77 0.47 6.02e-20 Alzheimer's disease; CRC cis rs9467711 0.606 rs9348726 chr6:26605206 G/A cg12315302 chr6:26189340 HIST1H4D 0.81 6.23 0.32 1.45e-9 Autism spectrum disorder or schizophrenia; CRC cis rs311392 0.967 rs4255114 chr8:55089450 G/A cg20636351 chr8:55087400 NA -0.33 -5.86 -0.31 1.11e-8 Pelvic organ prolapse (moderate/severe); CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg20314438 chr6:126661369 C6orf173 0.51 6.55 0.34 2.21e-10 Thyroid stimulating hormone; CRC cis rs8032158 1.000 rs8026172 chr15:56125182 T/A cg02198044 chr15:56286336 NEDD4 -0.38 -5.97 -0.31 6.31e-9 Keloid; CRC cis rs2859741 0.967 rs822854 chr1:37485788 A/G cg09363841 chr1:37513479 NA -0.62 -11.41 -0.53 1.23e-25 Forced expiratory volume in 1 second (environmental tobacco smoke interaction); CRC cis rs9894429 0.682 rs7406360 chr17:79591545 G/A cg21984481 chr17:79567631 NPLOC4 -0.58 -11.19 -0.52 7.81e-25 Eye color traits; CRC cis rs6500602 0.679 rs736685 chr16:4508606 T/C cg14951292 chr16:4525986 HMOX2;NMRAL1 0.59 9.09 0.45 9.49e-18 Schizophrenia; CRC cis rs6952808 0.510 rs13227554 chr7:2048220 G/C cg02951883 chr7:2050386 MAD1L1 0.63 10.43 0.5 3.47e-22 Bipolar disorder and schizophrenia; CRC cis rs9486715 0.838 rs9320127 chr6:96865358 G/A cg06623918 chr6:96969491 KIAA0776 1.01 20.09 0.74 3.94e-59 Headache; CRC cis rs11148252 0.538 rs9535885 chr13:52726524 A/G cg02158880 chr13:53174818 NA 0.42 6.0 0.31 5.07e-9 Lewy body disease; CRC cis rs8114671 0.562 rs6088640 chr20:33472509 C/T cg07148914 chr20:33460835 GGT7 0.37 6.2 0.32 1.67e-9 Height; CRC trans rs2303319 0.504 rs62189046 chr2:162612371 C/G cg20024234 chr21:43431083 ZNF295 -0.66 -5.99 -0.31 5.57e-9 Cognitive function; CRC cis rs9457247 0.967 rs402191 chr6:167405553 T/C cg23791538 chr6:167370224 RNASET2 -0.38 -5.94 -0.31 7.32e-9 Crohn's disease; CRC cis rs2739330 0.791 rs4822458 chr22:24265659 C/T cg10150615 chr22:24372951 LOC391322 -0.55 -8.34 -0.42 1.99e-15 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs34034915 1 rs34034915 chr6:27720703 T/TG cg20933634 chr6:27740509 NA 0.45 6.56 0.34 2.05e-10 Hepatitis A; CRC trans rs7618501 1.000 rs11130221 chr3:49819102 C/G cg21659725 chr3:3221576 CRBN 0.9 17.3 0.69 3.92e-48 Intelligence (multi-trait analysis); CRC trans rs1945213 0.694 rs34390414 chr11:55863367 T/G cg03929089 chr4:120376271 NA 0.55 6.37 0.33 6.43e-10 Acute lymphoblastic leukemia (childhood); CRC cis rs9928842 0.882 rs8048956 chr16:75254966 C/G cg09066997 chr16:75300724 BCAR1 -0.6 -6.1 -0.32 2.93e-9 Alcoholic chronic pancreatitis; CRC cis rs1552244 1.000 rs7610821 chr3:10136150 C/T cg10729496 chr3:10149963 C3orf24 0.49 6.58 0.34 1.83e-10 Alzheimer's disease; CRC cis rs6502050 0.835 rs34287733 chr17:80078236 C/T cg09264619 chr17:80180166 NA 0.37 6.15 0.32 2.26e-9 Life satisfaction; CRC cis rs4246215 1 rs4246215 chr11:61564299 G/T cg00603274 chr11:61596626 FADS2 -0.45 -6.57 -0.34 1.96e-10 Plasma omega-3 polyunsaturated fatty acid levels (alphalinolenic acid);Platelet count;Inflammatory bowel disease;Trans fatty acid levels;Crohn's disease;Plasma omega-3 polyunsaturated fatty acid level (eicosapentaenoic acid);Red blood cell fatty acid levels;Plasma omega-3 polyunsaturated fatty acid levels (docosapentaenoic acid); CRC cis rs7914558 1.000 rs6584540 chr10:104927634 A/G cg04362960 chr10:104952993 NT5C2 0.59 8.71 0.43 1.46e-16 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs12142240 0.698 rs12385696 chr1:46818836 A/G cg14993813 chr1:46806288 NSUN4 -0.48 -6.09 -0.32 3.09e-9 Menopause (age at onset); CRC trans rs9341835 0.772 rs9344090 chr6:64135830 G/A cg13657004 chr13:50234944 EBPL -0.37 -6.22 -0.32 1.48e-9 Schizophrenia; CRC cis rs2836950 0.585 rs1029004 chr21:40615343 A/G cg06238570 chr21:40685208 BRWD1 -0.61 -8.91 -0.44 3.68e-17 Menarche (age at onset); CRC cis rs172166 0.561 rs149973 chr6:27983613 G/T cg25164649 chr6:28176230 NA 0.46 6.76 0.35 6.23e-11 Cardiac Troponin-T levels; CRC cis rs9372498 0.536 rs62424199 chr6:118827252 G/A cg15382696 chr6:118971807 C6orf204 0.61 7.95 0.4 2.97e-14 Diastolic blood pressure; CRC cis rs7258465 1.000 rs7251653 chr19:18608283 C/T cg06953865 chr19:18549723 ISYNA1 -0.38 -5.74 -0.3 2.16e-8 Breast cancer; CRC trans rs2795502 1.000 rs2185717 chr10:43343875 G/A cg06791473 chr12:49259579 RND1 -0.62 -6.17 -0.32 2e-9 Blood protein levels; CRC cis rs282587 0.530 rs282602 chr13:113392644 G/A cg04656015 chr13:113407548 ATP11A 0.63 7.79 0.39 8.78e-14 Glycated hemoglobin levels; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg12991161 chr17:26684865 TMEM199;POLDIP2 0.52 7.29 0.37 2.27e-12 Response to antipsychotic treatment; CRC cis rs11711311 1.000 rs2242108 chr3:113433903 T/G cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.52 -6.97 -0.36 1.77e-11 IgG glycosylation; CRC cis rs12134245 0.874 rs17501937 chr1:92021705 C/T cg25838465 chr1:92012736 NA 0.56 9.29 0.46 2.22e-18 Breast cancer; CRC cis rs861020 0.630 rs585627 chr1:210004199 C/G cg05527609 chr1:210001259 C1orf107 0.77 10.68 0.51 4.51e-23 Orofacial clefts; CRC cis rs1005277 0.579 rs1780136 chr10:38501453 A/G cg03665457 chr10:38645376 HSD17B7P2 -0.42 -5.97 -0.31 6.02e-9 Extrinsic epigenetic age acceleration; CRC cis rs2227631 0.505 rs4729662 chr7:100765559 C/T cg18465962 chr7:100767262 NA 0.58 7.22 0.37 3.61e-12 Plasminogen activator inhibitor type 1 levels (PAI-1); CRC cis rs10743315 0.547 rs7310796 chr12:19362390 C/T cg02471346 chr12:19282374 PLEKHA5 -0.67 -8.35 -0.42 1.94e-15 Gut microbiota (bacterial taxa); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg15959319 chr5:32174494 GOLPH3 0.38 6.52 0.34 2.6e-10 Liver disease severity in Alagille syndrome; CRC cis rs832540 0.931 rs832535 chr5:56213334 C/T cg18230493 chr5:56204884 C5orf35 -0.39 -5.76 -0.3 1.91e-8 Coronary artery disease; CRC cis rs3617 0.598 rs56214994 chr3:52878600 G/C cg07507251 chr3:52567010 NT5DC2 -0.41 -6.35 -0.33 7.08e-10 Red blood cell count;Autism spectrum disorder or schizophrenia; CRC cis rs801193 0.967 rs2420827 chr7:66147101 G/A cg18876405 chr7:65276391 NA -0.58 -10.01 -0.48 9.21e-21 Aortic root size; CRC cis rs10744422 1.000 rs2135014 chr12:123333065 C/T cg25930673 chr12:123319894 HIP1R -0.6 -6.32 -0.33 8.36e-10 Schizophrenia; CRC cis rs9488822 0.676 rs12154016 chr6:116355188 C/T cg18764771 chr6:116381957 FRK 0.24 7.04 0.36 1.15e-11 Cholesterol, total;LDL cholesterol; CRC cis rs9916302 0.904 rs35335692 chr17:37710006 A/G cg07936489 chr17:37558343 FBXL20 -0.85 -13.48 -0.6 2.8e-33 Glomerular filtration rate (creatinine); CRC cis rs12142240 0.731 rs6681857 chr1:46850124 T/C cg00530320 chr1:46809349 NSUN4 0.59 8.06 0.41 1.43e-14 Menopause (age at onset); CRC cis rs875971 1.000 rs11974219 chr7:65647410 C/T cg18876405 chr7:65276391 NA -0.54 -9.46 -0.46 6.17e-19 Aortic root size; CRC cis rs7607369 0.791 rs12468043 chr2:219354197 C/A cg02176678 chr2:219576539 TTLL4 0.54 8.69 0.43 1.78e-16 Red blood cell count;Amyotrophic lateral sclerosis; CRC cis rs6066835 1.000 rs6066828 chr20:47344233 C/T cg18078177 chr20:47281410 PREX1 0.62 5.93 0.31 7.5e-9 Multiple myeloma; CRC cis rs921968 0.643 rs612874 chr2:219492924 T/C cg02176678 chr2:219576539 TTLL4 0.49 7.86 0.4 5.56e-14 Mean corpuscular hemoglobin concentration; CRC cis rs561341 1.000 rs564714 chr17:30318404 C/T cg23018236 chr17:30244563 NA -0.67 -7.99 -0.4 2.29e-14 Hip circumference adjusted for BMI; CRC trans rs57221529 0.766 rs72703026 chr5:572383 G/A cg25482853 chr8:67687455 SGK3 1.22 14.83 0.63 1.88e-38 Lung disease severity in cystic fibrosis; CRC cis rs2279817 0.908 rs12137775 chr1:18018927 G/T cg21791023 chr1:18019539 ARHGEF10L 0.54 6.4 0.33 5.26e-10 Neuroticism; CRC cis rs12142240 0.667 rs12062 chr1:46830447 G/T cg00530320 chr1:46809349 NSUN4 -0.58 -7.97 -0.4 2.68e-14 Menopause (age at onset); CRC cis rs1862618 0.756 rs13356762 chr5:56110992 G/T cg12311346 chr5:56204834 C5orf35 -0.79 -10.41 -0.5 4.04e-22 Initial pursuit acceleration; CRC cis rs9487051 0.676 rs9386788 chr6:109600523 C/T cg12927641 chr6:109611667 NA 0.34 6.04 0.32 4.13e-9 Reticulocyte fraction of red cells; CRC cis rs11098499 0.754 rs4443261 chr4:120249301 T/C cg24375607 chr4:120327624 NA 0.47 7.59 0.39 3.42e-13 Corneal astigmatism; CRC trans rs9329221 0.683 rs4598253 chr8:9890304 A/T cg06636001 chr8:8085503 FLJ10661 -0.52 -8.16 -0.41 7.39e-15 Neuroticism; CRC cis rs3768617 0.966 rs10797850 chr1:183094802 G/A ch.1.3577855R chr1:183094577 LAMC1 0.61 9.28 0.46 2.36e-18 Fuchs's corneal dystrophy; CRC cis rs6502050 0.835 rs4789737 chr17:80123269 G/A cg22110888 chr17:80059540 CCDC57 0.4 6.38 0.33 5.96e-10 Life satisfaction; CRC cis rs10791323 0.517 rs1120246 chr11:133745212 G/A cg15485101 chr11:133734466 NA 0.4 7.16 0.37 5.26e-12 Childhood ear infection; CRC cis rs728616 0.867 rs726289 chr10:81706951 C/T cg05935833 chr10:81318306 SFTPA2 -0.74 -8.13 -0.41 9.14e-15 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs4332037 0.539 rs55790766 chr7:2021248 C/T cg23378565 chr7:2036160 MAD1L1 -0.46 -6.53 -0.34 2.51e-10 Bipolar disorder; CRC trans rs2228479 0.850 rs11647174 chr16:89958538 G/A cg24644049 chr4:85504048 CDS1 0.91 7.97 0.4 2.59e-14 Skin colour saturation; CRC cis rs4722166 0.573 rs35436671 chr7:22775508 G/A cg05472934 chr7:22766657 IL6 0.78 12.66 0.57 3.39e-30 Lung cancer; CRC cis rs1865760 0.663 rs9379815 chr6:25980116 T/A cg18357526 chr6:26021779 HIST1H4A 0.41 5.98 0.31 5.66e-9 Height; CRC cis rs7618501 0.602 rs2240327 chr3:50113034 C/T cg24110177 chr3:50126178 RBM5 -0.49 -7.34 -0.38 1.71e-12 Intelligence (multi-trait analysis); CRC cis rs4423214 1.000 rs4944958 chr11:71168073 A/G cg05163923 chr11:71159392 DHCR7 0.65 9.14 0.45 6.38e-18 Vitamin D levels; CRC cis rs7589728 0.563 rs79892776 chr2:88470593 G/A cg07952391 chr2:88470173 THNSL2 0.66 6.76 0.35 6.44e-11 Plasma clusterin levels; CRC cis rs4713118 0.784 rs9468219 chr6:27731755 C/A cg19041857 chr6:27730383 NA -0.46 -6.42 -0.33 4.87e-10 Parkinson's disease; CRC trans rs2228479 0.850 rs2238525 chr16:89809902 T/C cg24644049 chr4:85504048 CDS1 0.69 6.01 0.31 4.99e-9 Skin colour saturation; CRC cis rs13118159 0.836 rs12647145 chr4:1338618 C/A cg21620606 chr4:1342894 KIAA1530 0.4 7.15 0.37 5.57e-12 Longevity; CRC cis rs2180341 0.538 rs3756993 chr6:127651551 A/C cg24812749 chr6:127587940 RNF146 0.64 9.59 0.47 2.37e-19 Breast cancer; CRC cis rs853679 0.517 rs67878650 chr6:28142587 G/C cg06470822 chr6:28175283 NA 1.01 13.28 0.59 1.55e-32 Depression; CRC cis rs523522 0.962 rs687873 chr12:121019634 G/A cg12219531 chr12:120966889 COQ5 0.69 9.12 0.45 7.92e-18 High light scatter reticulocyte count; CRC cis rs6540559 0.673 rs2357230 chr1:210019498 G/A cg21951975 chr1:209979733 IRF6 0.46 5.6 0.3 4.48e-8 Cleft lip with or without cleft palate; CRC cis rs9372498 0.536 rs62424199 chr6:118827252 G/A cg07617317 chr6:118971624 C6orf204 0.5 6.26 0.33 1.22e-9 Diastolic blood pressure; CRC cis rs73200209 0.744 rs7959347 chr12:116479781 A/G cg01776926 chr12:116560359 MED13L -0.64 -7.69 -0.39 1.74e-13 Total body bone mineral density; CRC cis rs2290405 0.527 rs7663192 chr4:923947 T/C cg04824913 chr4:887549 GAK 0.72 10.91 0.52 7.23e-24 Systemic sclerosis; CRC cis rs2239547 0.657 rs3755803 chr3:52866157 C/G cg15147215 chr3:52552868 STAB1 -0.43 -6.05 -0.32 3.92e-9 Schizophrenia; CRC trans rs116095464 0.558 rs62346508 chr5:203668 T/C cg00938859 chr5:1591904 SDHAP3 0.65 6.02 0.31 4.63e-9 Breast cancer; CRC trans rs3733585 0.699 rs11724510 chr4:9958583 C/T cg26043149 chr18:55253948 FECH -0.48 -7.43 -0.38 9.29e-13 Cleft plate (environmental tobacco smoke interaction); CRC cis rs13108904 0.935 rs2199956 chr4:1248919 A/G cg23123621 chr4:1343375 KIAA1530 0.36 6.51 0.34 2.8e-10 Obesity-related traits; CRC cis rs6582630 0.519 rs11514372 chr12:38308613 T/G cg13010199 chr12:38710504 ALG10B 0.46 6.25 0.33 1.28e-9 Drug-induced liver injury (flucloxacillin); CRC cis rs4268898 0.931 rs55642516 chr2:24502305 A/G cg06627628 chr2:24431161 ITSN2 -0.58 -8.75 -0.43 1.16e-16 Asthma; CRC cis rs8072100 0.790 rs34200664 chr17:45744652 C/T cg08085267 chr17:45401833 C17orf57 0.55 8.44 0.42 1e-15 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs6496667 0.779 rs2107436 chr15:91042921 A/T cg04176472 chr15:90893244 GABARAPL3 0.54 7.79 0.39 9.1e-14 Rheumatoid arthritis; CRC cis rs7666738 0.581 rs34205844 chr4:98887494 C/A cg17366294 chr4:99064904 C4orf37 0.4 6.59 0.34 1.71e-10 Colonoscopy-negative controls vs population controls; CRC cis rs35883536 0.647 rs7535762 chr1:101047534 A/G cg06223162 chr1:101003688 GPR88 -0.34 -6.14 -0.32 2.42e-9 Monocyte count; CRC cis rs4713118 0.869 rs9283880 chr6:27715243 A/C cg21251018 chr6:28226885 NKAPL 0.38 5.74 0.3 2.13e-8 Parkinson's disease; CRC trans rs7395662 1.000 rs11039800 chr11:48542579 C/T cg21153622 chr11:89784906 NA 0.43 6.8 0.35 4.85e-11 HDL cholesterol; CRC cis rs972578 0.967 rs1883314 chr22:43374807 G/C cg01576275 chr22:43409880 NA -0.49 -7.84 -0.4 6.52e-14 Mean platelet volume; CRC cis rs9733 0.543 rs72702558 chr1:150683251 G/A cg10589385 chr1:150898437 SETDB1 0.28 5.96 0.31 6.66e-9 Tonsillectomy; CRC cis rs727563 0.594 rs5758408 chr22:42077737 A/C cg03806693 chr22:41940476 POLR3H 1.05 13.07 0.58 1.02e-31 Crohn's disease;Inflammatory bowel disease; CRC cis rs4891159 0.505 rs680253 chr18:74167427 A/C cg24786174 chr18:74118243 ZNF516 -0.79 -16.35 -0.67 2.2e-44 Longevity; CRC cis rs853679 0.517 rs4713144 chr6:28106790 C/G cg23161317 chr6:28129485 ZNF389 0.53 6.54 0.34 2.37e-10 Depression; CRC cis rs12540874 0.794 rs1470750 chr7:50576648 C/G cg18232548 chr7:50535776 DDC -0.5 -7.3 -0.37 2.25e-12 Systemic sclerosis; CRC cis rs514406 0.861 rs35517489 chr1:53304062 G/C cg25767906 chr1:53392781 SCP2 -0.42 -6.76 -0.35 6.19e-11 Monocyte count; CRC cis rs7927592 0.830 rs10896339 chr11:68302846 G/C cg01657329 chr11:68192670 LRP5 -0.48 -7.33 -0.37 1.76e-12 Total body bone mineral density; CRC cis rs782590 0.517 rs13013133 chr2:55889466 G/A cg18811423 chr2:55921094 PNPT1 -0.66 -8.94 -0.44 2.95e-17 Metabolic syndrome; CRC cis rs7617480 0.544 rs6442129 chr3:48735256 T/C cg20833759 chr3:49053208 WDR6;DALRD3 0.59 9.09 0.45 9.3e-18 Subjective well-being (multi-trait analysis);Menarche (age at onset); CRC cis rs10992471 0.603 rs9299405 chr9:95284873 A/G cg14631576 chr9:95140430 CENPP -0.39 -6.76 -0.35 6.18e-11 Visceral adipose tissue/subcutaneous adipose tissue ratio; CRC cis rs4665809 0.590 rs2303892 chr2:26461733 C/G cg27170947 chr2:26402098 FAM59B 0.6 7.82 0.4 7.45e-14 Gut microbiome composition (summer); CRC cis rs2279817 0.735 rs12075624 chr1:17991573 A/G cg21791023 chr1:18019539 ARHGEF10L -0.49 -5.78 -0.3 1.71e-8 Neuroticism; CRC cis rs11758351 1.000 rs16891378 chr6:26188864 A/G cg01420254 chr6:26195488 NA 0.8 8.61 0.43 2.98e-16 Gout;Renal underexcretion gout; CRC cis rs11112613 0.775 rs7959699 chr12:105959848 C/A cg03607813 chr12:105948248 NA 0.75 10.06 0.49 6.23e-21 Corrected insulin response;Corrected insulin response adjusted for insulin sensitivity index; CRC cis rs3785574 0.962 rs2727332 chr17:61878584 T/A cg23090583 chr17:61904693 PSMC5;FTSJ3 0.66 9.62 0.47 1.8e-19 Height; CRC cis rs9326248 0.520 rs236919 chr11:117095361 A/G cg10398005 chr11:117014888 PAFAH1B2 -0.41 -6.14 -0.32 2.34e-9 Blood protein levels; CRC cis rs7249142 0.527 rs12975096 chr19:19279409 G/T cg08207377 chr19:19281140 LOC729991-MEF2B;MEF2B -0.37 -6.04 -0.32 4.17e-9 IgG glycosylation; CRC cis rs11155671 0.530 rs2342767 chr6:150209717 C/G cg13206674 chr6:150067644 NUP43 0.49 7.04 0.36 1.13e-11 Testicular germ cell tumor; CRC cis rs7617773 0.817 rs9853804 chr3:48327729 T/C cg11946769 chr3:48343235 NME6 0.64 8.85 0.44 5.61e-17 Coronary artery disease; CRC cis rs9640161 0.830 rs3757423 chr7:150067714 A/G cg13722127 chr7:150037890 RARRES2 -0.37 -5.95 -0.31 6.69e-9 Blood protein levels;Circulating chemerin levels; CRC cis rs9322193 0.926 rs2342860 chr6:150098777 T/C cg05861140 chr6:150128134 PCMT1 -0.43 -7.05 -0.36 1.03e-11 Lung cancer; CRC cis rs7772486 0.686 rs6570701 chr6:145954090 A/G cg13319975 chr6:146136371 FBXO30 -0.44 -6.65 -0.34 1.26e-10 Lobe attachment (rater-scored or self-reported); CRC cis rs4319547 0.656 rs9788145 chr12:122899522 C/T cg05707623 chr12:122985044 ZCCHC8 -0.7 -8.69 -0.43 1.78e-16 Body mass index; CRC cis rs2811415 0.627 rs4602340 chr3:127732942 A/C cg13719885 chr3:127795394 NA -0.37 -5.66 -0.3 3.24e-8 Lung function (FEV1/FVC); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg00715988 chr14:96968640 PAPOLA 0.42 6.4 0.33 5.21e-10 Liver disease severity in Alagille syndrome; CRC cis rs10256972 0.732 rs12701856 chr7:1107707 C/T cg03923535 chr7:1197113 ZFAND2A 0.58 8.19 0.41 5.69e-15 Longevity;Endometriosis; CRC cis rs3015497 0.586 rs12587821 chr14:51092554 A/G cg09863266 chr14:51125203 SAV1 -0.3 -5.76 -0.3 1.92e-8 Mean platelet volume; CRC cis rs9287719 0.967 rs728134 chr2:10745187 A/G cg00105475 chr2:10696890 NA 0.45 7.21 0.37 3.91e-12 Prostate cancer; CRC cis rs3820068 0.581 rs72645889 chr1:15930251 T/G cg13390004 chr1:15929781 NA 0.51 7.2 0.37 4.22e-12 Systolic blood pressure; CRC trans rs10838798 0.584 rs1566732 chr11:48151494 A/C cg21153622 chr11:89784906 NA 0.43 6.7 0.35 9.1e-11 Height; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg15620385 chr12:26986279 ITPR2 0.37 6.32 0.33 8.62e-10 Liver disease severity in Alagille syndrome; CRC cis rs3768617 0.782 rs12146099 chr1:182968079 G/A ch.1.3577855R chr1:183094577 LAMC1 0.6 8.65 0.43 2.36e-16 Fuchs's corneal dystrophy; CRC cis rs11792861 0.816 rs11788336 chr9:111688387 T/C cg05043794 chr9:111880884 C9orf5 -0.32 -5.75 -0.3 1.99e-8 Menarche (age at onset); CRC trans rs8073060 0.544 rs7210966 chr17:33986334 G/C cg19694781 chr19:47549865 TMEM160 -1.08 -15.9 -0.66 1.28e-42 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg05360402 chr5:110848191 STARD4 0.44 6.13 0.32 2.47e-9 Response to antipsychotic treatment; CRC cis rs6088580 0.634 rs6087577 chr20:32955423 C/T cg08999081 chr20:33150536 PIGU 0.56 10.03 0.48 8.05e-21 Glomerular filtration rate (creatinine); CRC cis rs1552244 0.882 rs6443276 chr3:10008905 C/A cg13047869 chr3:10149882 C3orf24 0.52 7.06 0.36 9.86e-12 Alzheimer's disease; CRC cis rs7833790 0.724 rs12676336 chr8:82771008 C/T cg27398817 chr8:82754497 SNX16 0.43 5.85 0.31 1.21e-8 Diastolic blood pressure; CRC cis rs7224685 0.501 rs812996 chr17:3965674 T/C cg09695851 chr17:3907499 NA 0.76 14.45 0.62 5.69e-37 Type 2 diabetes; CRC cis rs910316 0.646 rs11546525 chr14:75537381 C/T cg03030879 chr14:75389066 RPS6KL1 -0.59 -8.95 -0.44 2.75e-17 Height; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg24707616 chr17:16342815 NCRNA00188;SNORD49B;SNORD49A 0.52 7.53 0.38 5.04e-13 Response to antipsychotic treatment; CRC cis rs2070997 0.667 rs7851946 chr9:133719256 A/T cg01000188 chr9:133769184 QRFP -0.44 -5.64 -0.3 3.62e-8 Response to amphetamines; CRC cis rs35110281 0.748 rs2838322 chr21:44998615 G/C cg04455712 chr21:45112962 RRP1B 0.43 8.3 0.42 2.7e-15 Mean corpuscular volume; CRC cis rs16852403 0.548 rs1412784 chr1:178206664 A/G cg00404053 chr1:178313656 RASAL2 0.5 6.53 0.34 2.55e-10 Childhood ear infection; CRC cis rs10876993 0.855 rs1689601 chr12:58049557 G/A cg18357645 chr12:58087776 OS9 0.58 7.89 0.4 4.61e-14 Celiac disease or Rheumatoid arthritis; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg03209496 chr7:99725123 MBLAC1 0.43 6.24 0.33 1.35e-9 Intelligence (multi-trait analysis); CRC cis rs904251 0.523 rs2776920 chr6:37480605 G/A cg01843034 chr6:37503916 NA -0.44 -8.2 -0.41 5.61e-15 Cognitive performance; CRC cis rs826838 1.000 rs826838 chr12:39106731 C/T cg26384229 chr12:38710491 ALG10B -0.62 -9.59 -0.47 2.26e-19 Heart rate; CRC cis rs6662572 1.000 rs72688460 chr1:46111094 C/T cg08644498 chr1:46502608 NA 0.44 6.05 0.32 3.95e-9 Blood protein levels; CRC cis rs11690935 0.959 rs6722757 chr2:172591963 A/G cg13550731 chr2:172543902 DYNC1I2 -1.09 -17.82 -0.7 3.5e-50 Schizophrenia; CRC cis rs1609391 0.543 rs6800690 chr3:136623026 G/A cg15507776 chr3:136538369 TMEM22 0.34 6.16 0.32 2.18e-9 Neuroticism; CRC cis rs1059312 0.808 rs12816551 chr12:129295616 T/C cg23521905 chr12:129298690 SLC15A4;MGC16384 0.38 6.58 0.34 1.85e-10 Systemic lupus erythematosus; CRC cis rs9487051 0.768 rs463916 chr6:109520538 A/G cg21918786 chr6:109611834 NA -0.33 -5.72 -0.3 2.33e-8 Reticulocyte fraction of red cells; CRC cis rs7224685 0.501 rs11650023 chr17:4012850 C/T cg09597638 chr17:3907349 NA -0.67 -11.85 -0.55 3.17e-27 Type 2 diabetes; CRC cis rs77216612 0.835 rs10845621 chr12:12887977 C/T cg04607235 chr12:12878440 APOLD1 -1.03 -14.23 -0.62 3.94e-36 Lymphocyte counts; CRC cis rs6938 0.618 rs11633472 chr15:75184084 T/G cg18612461 chr15:75251733 NA 0.4 6.18 0.32 1.94e-9 Breast cancer; CRC cis rs344364 0.511 rs12596510 chr16:1949480 G/A cg09830162 chr16:1889614 FAHD1;C16orf73 -0.77 -9.36 -0.46 1.32e-18 Glomerular filtration rate in chronic kidney disease; CRC cis rs6495122 0.501 rs12148488 chr15:75382542 G/T cg09165964 chr15:75287851 SCAMP5 -0.52 -8.25 -0.41 3.97e-15 Caffeine consumption;Diastolic blood pressure;Coffee consumption; CRC cis rs6952808 0.609 rs4721190 chr7:1954732 A/G cg02951883 chr7:2050386 MAD1L1 0.57 9.38 0.46 1.14e-18 Bipolar disorder and schizophrenia; CRC cis rs4819052 0.851 rs8133045 chr21:46658137 A/G cg19498844 chr21:46707878 POFUT2;LOC642852 0.77 10.99 0.52 3.97e-24 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs9291683 0.620 rs4444830 chr4:10124819 A/G cg00071950 chr4:10020882 SLC2A9 -0.46 -7.16 -0.37 5.3e-12 Bone mineral density; CRC cis rs3736485 0.966 rs10519312 chr15:51912971 A/G cg08986416 chr15:51914746 DMXL2 -0.45 -6.38 -0.33 5.86e-10 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs7666738 0.830 rs28522896 chr4:99008243 C/T cg05340658 chr4:99064831 C4orf37 0.61 9.54 0.47 3.44e-19 Colonoscopy-negative controls vs population controls; CRC cis rs4642101 0.640 rs12629398 chr3:12826799 A/G cg24848339 chr3:12840334 CAND2 0.3 5.67 0.3 3.09e-8 QRS complex (12-leadsum); CRC cis rs2635047 0.638 rs1434529 chr18:44730142 C/T cg19077165 chr18:44547161 KATNAL2 -0.42 -6.47 -0.34 3.5e-10 Educational attainment; CRC cis rs10779751 0.770 rs12097293 chr1:11197467 A/G cg08854313 chr1:11322531 MTOR -0.62 -7.72 -0.39 1.44e-13 Body mass index; CRC cis rs10504229 0.775 rs17805026 chr8:58160637 A/C cg24829409 chr8:58192753 C8orf71 -0.6 -8.07 -0.41 1.29e-14 Developmental language disorder (linguistic errors); CRC cis rs67311347 1.000 rs9835219 chr3:40424093 C/T cg24209194 chr3:40518798 ZNF619 0.4 5.89 0.31 9.44e-9 Renal cell carcinoma; CRC cis rs72781680 1.000 rs72788286 chr2:24098321 A/C cg08917208 chr2:24149416 ATAD2B 0.89 9.04 0.45 1.4e-17 Lymphocyte counts; CRC cis rs933688 0.941 rs11948056 chr5:90680468 A/C cg02339078 chr5:90679543 LOC100129716;ARRDC3 0.92 15.57 0.65 2.39e-41 Smoking behavior; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg08456130 chr6:151773385 RMND1;C6orf211 0.49 7.52 0.38 5.21e-13 Liver disease severity in Alagille syndrome; CRC trans rs2243480 1.000 rs2420170 chr7:65656053 T/C cg10756647 chr7:56101905 PSPH -0.77 -7.85 -0.4 5.93e-14 Diabetic kidney disease; CRC cis rs28386778 0.897 rs1982400 chr17:61793818 T/C cg25654072 chr17:61904446 PSMC5;FTSJ3 0.7 10.89 0.51 8.92e-24 Prudent dietary pattern; CRC cis rs7223966 1.000 rs7223672 chr17:61720565 T/C cg05941027 chr17:61774174 LIMD2 0.35 6.38 0.33 5.92e-10 Hip circumference adjusted for BMI;Body mass index; CRC cis rs10035650 0.546 rs11949638 chr5:93907889 C/T cg21051031 chr5:93905482 C5orf36;MIR1974 -0.38 -6.16 -0.32 2.08e-9 Cancer; CRC cis rs753778 0.570 rs6985866 chr8:142210336 C/T cg23750338 chr8:142222470 SLC45A4 -0.39 -6.69 -0.35 9.42e-11 Reticulocyte fraction of red cells;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; CRC cis rs703842 0.928 rs724834 chr12:58180416 G/C cg00677455 chr12:58241039 CTDSP2 0.64 8.58 0.43 3.84e-16 Multiple sclerosis; CRC cis rs9560113 1.000 rs9555804 chr13:112179751 T/C cg10483660 chr13:112241077 NA 0.36 5.81 0.3 1.49e-8 Menarche (age at onset); CRC cis rs75920871 0.528 rs7124872 chr11:116927951 C/T cg01368799 chr11:117014884 PAFAH1B2 0.41 5.83 0.31 1.31e-8 Subjective well-being; CRC cis rs3892630 1.000 rs3892630 chr19:33181484 A/G cg22980127 chr19:33182716 NUDT19 -0.93 -11.65 -0.54 1.67e-26 Red blood cell traits; CRC cis rs7264396 0.635 rs6060719 chr20:34546013 A/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.61 -9.82 -0.48 4.01e-20 Total cholesterol levels; CRC cis rs8177253 0.634 rs6798547 chr3:133448499 G/A cg24879335 chr3:133465180 TF 0.37 6.86 0.35 3.44e-11 Iron status biomarkers; CRC cis rs3736594 0.513 rs6751087 chr2:27778016 T/C cg27432699 chr2:27873401 GPN1 0.66 8.49 0.42 7.24e-16 Fasting blood glucose;Fasting blood glucose (BMI interaction); CRC cis rs4481887 0.538 rs10888328 chr1:248378777 G/A cg00666640 chr1:248458726 OR2T12 0.43 7.58 0.39 3.62e-13 Common traits (Other); CRC cis rs10924970 0.687 rs10802441 chr1:235357698 A/T cg09010748 chr1:235293032 TOMM20 -0.4 -5.65 -0.3 3.5e-8 Asthma; CRC cis rs7589728 0.563 rs80324973 chr2:88447264 T/G cg07952391 chr2:88470173 THNSL2 0.69 7.1 0.36 7.77e-12 Plasma clusterin levels; CRC cis rs12230513 0.732 rs4318592 chr12:55837124 C/A cg19537932 chr12:55886519 OR6C68 -0.73 -9.49 -0.46 5.01e-19 Contrast sensitivity; CRC cis rs7119 0.717 rs35284122 chr15:77804568 G/T cg27398640 chr15:77910606 LINGO1 -0.46 -7.98 -0.4 2.48e-14 Type 2 diabetes; CRC cis rs11122272 0.735 rs2355873 chr1:231477442 A/G cg06096015 chr1:231504339 EGLN1 0.38 5.62 0.3 4.02e-8 Hemoglobin concentration; CRC cis rs7542091 0.813 rs2049999 chr1:210031331 A/G cg22029157 chr1:209979665 IRF6 0.51 8.35 0.42 1.94e-15 Monobrow; CRC cis rs9611565 0.765 rs727563 chr22:41867377 C/T cg06634786 chr22:41940651 POLR3H 0.44 5.85 0.31 1.18e-8 Vitiligo; CRC cis rs3617 0.652 rs60332615 chr3:52867595 C/A cg18099408 chr3:52552593 STAB1 0.35 6.02 0.32 4.63e-9 Red blood cell count;Autism spectrum disorder or schizophrenia; CRC cis rs7827545 1.000 rs6995244 chr8:135568959 A/G cg17885191 chr8:135476712 NA 0.53 7.39 0.38 1.23e-12 Hypertension (SNP x SNP interaction); CRC cis rs2530545 0.543 rs61121916 chr7:34671351 G/T cg14401837 chr7:34697493 NPSR1 0.54 5.67 0.3 3.17e-8 IgG glycosylation; CRC cis rs6951245 1.000 rs11761941 chr7:1097183 G/A cg04025307 chr7:1156635 C7orf50 0.64 6.81 0.35 4.53e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs7923609 0.869 rs9971352 chr10:65265108 A/T cg08743896 chr10:65200160 JMJD1C -0.42 -5.94 -0.31 7.27e-9 Educational attainment;Liver enzyme levels (alkaline phosphatase); CRC cis rs3857067 1.000 rs7694631 chr4:95016931 G/C cg11021082 chr4:95130006 SMARCAD1 -0.4 -6.05 -0.32 3.9e-9 QT interval; CRC cis rs7666738 0.830 rs6852015 chr4:99054373 C/A cg05340658 chr4:99064831 C4orf37 0.6 9.37 0.46 1.17e-18 Colonoscopy-negative controls vs population controls; CRC cis rs4665809 0.590 rs1560865 chr2:26452197 C/A cg08067268 chr2:26466485 HADHB;HADHA -0.64 -8.33 -0.42 2.17e-15 Gut microbiome composition (summer); CRC cis rs2153535 0.580 rs2327056 chr6:8443305 C/T cg21535247 chr6:8435926 SLC35B3 0.48 7.24 0.37 3.19e-12 Motion sickness; CRC cis rs2840044 1.000 rs225243 chr17:33947212 A/G cg05299278 chr17:33885742 SLFN14 0.4 5.99 0.31 5.59e-9 Response to radiotherapy in cancer (late toxicity); CRC cis rs4713118 0.869 rs6922574 chr6:27693003 A/T cg06470822 chr6:28175283 NA 0.68 9.25 0.45 3e-18 Parkinson's disease; CRC trans rs61931739 0.500 rs11053213 chr12:34466395 G/T cg26384229 chr12:38710491 ALG10B 0.68 8.9 0.44 3.69e-17 Morning vs. evening chronotype; CRC cis rs2559856 1.000 rs2695284 chr12:102089318 A/G cg12924262 chr12:102091054 CHPT1 -0.53 -8.1 -0.41 1.11e-14 Blood protein levels; CRC cis rs4713675 0.546 rs2296739 chr6:33656969 G/A cg14003231 chr6:33640908 ITPR3 0.55 8.71 0.43 1.46e-16 Plateletcrit; CRC cis rs9527 0.590 rs11191540 chr10:104822809 G/C cg15744005 chr10:104629667 AS3MT -0.3 -5.96 -0.31 6.54e-9 Arsenic metabolism; CRC cis rs7615952 0.641 rs12495947 chr3:125771698 C/T cg04553112 chr3:125709451 NA -0.51 -5.89 -0.31 9.55e-9 Blood pressure (smoking interaction); CRC cis rs7772486 0.754 rs9386133 chr6:146141213 A/G cg13319975 chr6:146136371 FBXO30 -0.43 -6.37 -0.33 6.31e-10 Lobe attachment (rater-scored or self-reported); CRC cis rs72781680 0.752 rs72796116 chr2:23913769 C/T cg08917208 chr2:24149416 ATAD2B 1.01 9.35 0.46 1.42e-18 Lymphocyte counts; CRC cis rs2411233 1.000 rs11070163 chr15:39277151 A/G cg23129342 chr15:39283510 NA -0.32 -6.05 -0.32 3.87e-9 Platelet count; CRC cis rs10504229 0.953 rs75545548 chr8:58172816 T/C cg02725872 chr8:58115012 NA -0.38 -6.43 -0.33 4.44e-10 Developmental language disorder (linguistic errors); CRC trans rs12408261 0.685 rs4085125 chr1:189277546 A/T cg18397308 chr19:18672850 C19orf50 0.43 6.42 0.33 4.8e-10 Number of pregnancies; CRC cis rs780096 0.526 rs704791 chr2:27657167 T/C cg12648201 chr2:27665141 KRTCAP3 -0.32 -6.36 -0.33 6.91e-10 Total body bone mineral density; CRC cis rs55794721 0.509 rs2375313 chr1:25748235 G/A cg20684491 chr1:25596433 NA 0.42 7.48 0.38 6.74e-13 Plateletcrit;Mean corpuscular volume; CRC cis rs11229555 0.874 rs10896794 chr11:58339124 T/C cg15696309 chr11:58395628 NA -0.95 -12.73 -0.57 1.82e-30 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg03952484 chr1:149899818 SF3B4 0.52 7.33 0.37 1.78e-12 Response to antipsychotic treatment; CRC cis rs7493 0.760 rs17876092 chr7:95053313 C/A cg20119798 chr7:94954144 PON1 -0.53 -6.54 -0.34 2.35e-10 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs9462846 0.691 rs7744454 chr6:42914041 C/G cg02353165 chr6:42928485 GNMT 0.63 8.77 0.44 9.53e-17 Blood protein levels; CRC cis rs798554 0.757 rs1182179 chr7:2873648 A/G cg17321639 chr7:2759063 NA -0.54 -7.32 -0.37 1.93e-12 Height; CRC cis rs13315871 1.000 rs74834816 chr3:58321828 G/A cg20936604 chr3:58311152 NA -0.77 -7.34 -0.38 1.65e-12 Cholesterol, total; CRC cis rs1862618 0.529 rs978406 chr5:56259808 A/T cg18230493 chr5:56204884 C5orf35 0.81 10.97 0.52 4.6e-24 Initial pursuit acceleration; CRC cis rs911186 0.891 rs6914824 chr6:27139048 C/T cg12292205 chr6:26970375 C6orf41 -0.77 -8.16 -0.41 7.07e-15 Autism spectrum disorder or schizophrenia; CRC trans rs11098499 0.731 rs9995026 chr4:120490499 T/A cg25214090 chr10:38739885 LOC399744 0.66 10.34 0.5 6.8e-22 Corneal astigmatism; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg18531175 chr5:43483681 C5orf28 0.38 6.14 0.32 2.32e-9 Liver disease severity in Alagille syndrome; CRC cis rs883565 0.655 rs6599000 chr3:39061512 A/G cg01426195 chr3:39028469 NA -0.53 -8.58 -0.43 3.86e-16 Handedness; CRC trans rs4263408 0.934 rs9683743 chr4:39703194 A/C cg06538757 chr5:177631493 HNRNPAB -0.41 -6.05 -0.32 3.86e-9 Plasma amyloid beta peptide concentrations (ABx-40); CRC cis rs7429990 0.864 rs319693 chr3:47886580 G/T cg11946769 chr3:48343235 NME6 0.45 5.78 0.3 1.72e-8 Educational attainment (years of education); CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg06805064 chr13:52263093 WDFY2 -0.44 -6.09 -0.32 3.1e-9 Myopia (pathological); CRC cis rs875971 0.545 rs4441996 chr7:65588220 T/C cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.61 -7.88 -0.4 4.99e-14 Aortic root size; CRC cis rs10504229 0.775 rs17805110 chr8:58161439 C/G cg02725872 chr8:58115012 NA 0.59 9.18 0.45 5.05e-18 Developmental language disorder (linguistic errors); CRC cis rs798554 0.660 rs2283783 chr7:2855326 G/A cg19717773 chr7:2847554 GNA12 -0.51 -8.46 -0.42 8.79e-16 Height; CRC cis rs2070488 0.775 rs6599204 chr3:38525734 C/T cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.68 11.42 0.53 1.12e-25 Electrocardiographic conduction measures; CRC cis rs4665809 0.590 rs2891496 chr2:26452605 G/A cg25036284 chr2:26402008 FAM59B 0.62 7.86 0.4 5.64e-14 Gut microbiome composition (summer); CRC cis rs2346177 0.844 rs12991646 chr2:46643831 A/G cg26688816 chr2:46740690 ATP6V1E2 -0.47 -6.87 -0.35 3.27e-11 HDL cholesterol; CRC cis rs9311474 0.508 rs6786043 chr3:52604861 A/G cg15147215 chr3:52552868 STAB1 -0.63 -10.98 -0.52 4.02e-24 Electroencephalogram traits; CRC cis rs7677751 0.806 rs6554163 chr4:55102559 A/T cg00691999 chr4:55094011 PDGFRA 0.42 6.25 0.33 1.31e-9 Corneal astigmatism; CRC cis rs35264875 0.898 rs72928701 chr11:68861564 C/T cg03469862 chr11:68924853 NA 0.47 6.03 0.32 4.33e-9 Blond vs. brown hair color; CRC trans rs7726839 0.540 rs55929359 chr5:595956 C/G cg11887960 chr12:57824829 NA 0.59 6.66 0.34 1.16e-10 Obesity-related traits; CRC cis rs7249142 0.549 rs12609573 chr19:19297567 C/T cg26504305 chr19:19281019 LOC729991-MEF2B;MEF2B 0.42 8.58 0.43 3.72e-16 IgG glycosylation; CRC cis rs875971 0.862 rs1875057 chr7:65731855 A/G cg18876405 chr7:65276391 NA -0.52 -8.34 -0.42 2.06e-15 Aortic root size; CRC cis rs10486722 0.607 rs2108173 chr7:41771295 G/C cg22138096 chr7:41772439 LOC285954 0.71 8.34 0.42 2.07e-15 Pit-and-Fissure caries; CRC cis rs4332037 0.615 rs62435127 chr7:1884937 A/G cg21155852 chr7:2048760 MAD1L1 -0.42 -6.07 -0.32 3.57e-9 Bipolar disorder; CRC cis rs10504229 0.775 rs56155911 chr8:58163247 C/T cg11062466 chr8:58055876 NA 0.45 5.82 0.31 1.39e-8 Developmental language disorder (linguistic errors); CRC cis rs7726839 0.574 rs72707007 chr5:661856 T/C cg09021430 chr5:549028 NA -0.72 -8.04 -0.41 1.6e-14 Obesity-related traits; CRC trans rs1373453 0.908 rs17106874 chr12:70044923 G/A cg06033789 chr8:105899330 NA 0.42 6.03 0.32 4.51e-9 Orofacial clefts; CRC cis rs7811142 1.000 rs7787620 chr7:100089234 A/G cg00814883 chr7:100076585 TSC22D4 -0.74 -9.36 -0.46 1.31e-18 Platelet count; CRC cis rs4664308 1.000 rs6707458 chr2:160914540 G/T cg03641300 chr2:160917029 PLA2R1 -0.73 -12.59 -0.57 6.05e-30 Idiopathic membranous nephropathy; CRC cis rs4237845 0.537 rs7312623 chr12:58262523 G/T cg00677455 chr12:58241039 CTDSP2 0.83 12.17 0.56 2.24e-28 Intelligence (multi-trait analysis); CRC cis rs11123170 0.640 rs1015754 chr2:113967990 T/C cg11763394 chr2:113992921 PAX8;LOC440839;LOC654433 -0.56 -7.51 -0.38 5.51e-13 Renal function-related traits (BUN); CRC cis rs9902453 0.904 rs11654983 chr17:28370042 A/C cg26525008 chr17:28256777 EFCAB5;SSH2 -0.69 -11.3 -0.53 3.04e-25 Coffee consumption (cups per day); CRC cis rs9341808 0.591 rs7741013 chr6:80916330 G/A cg08355045 chr6:80787529 NA 0.33 5.73 0.3 2.22e-8 Sitting height ratio; CRC cis rs1609391 0.543 rs6761993 chr3:136625902 C/T cg15507776 chr3:136538369 TMEM22 0.34 6.16 0.32 2.18e-9 Neuroticism; CRC cis rs12449964 0.524 rs4925092 chr17:17568931 A/G cg16928487 chr17:17741425 SREBF1 -0.34 -5.74 -0.3 2.12e-8 Coronary artery disease or ischemic stroke; CRC cis rs1538970 0.962 rs2153607 chr1:45813820 G/A cg05343316 chr1:45956843 TESK2 0.64 8.98 0.44 2.19e-17 Platelet count; CRC cis rs10751667 0.961 rs7395928 chr11:952605 T/G cg23136738 chr11:925521 AP2A2 -0.5 -8.18 -0.41 6.27e-15 Alzheimer's disease (late onset); CRC cis rs2346177 1.000 rs2346177 chr2:46642249 A/G cg26688816 chr2:46740690 ATP6V1E2 0.5 8.2 0.41 5.41e-15 HDL cholesterol; CRC cis rs3849570 0.961 rs3772896 chr3:81751968 C/T cg07356753 chr3:81810745 GBE1 -0.75 -11.2 -0.53 6.91e-25 Waist circumference;Body mass index; CRC cis rs9549367 0.789 rs912012 chr13:113886152 G/A cg00898013 chr13:113819073 PROZ -0.46 -6.79 -0.35 5.37e-11 Platelet distribution width; CRC cis rs6546324 0.625 rs2861689 chr2:67838604 C/G cg15745817 chr2:67799979 NA -0.53 -9.29 -0.46 2.25e-18 Endometriosis; CRC cis rs6543140 0.964 rs6748390 chr2:103062175 A/G cg04239558 chr2:103089729 SLC9A4 0.35 6.07 0.32 3.58e-9 Blood protein levels; CRC cis rs2239547 0.603 rs59989280 chr3:53098875 T/C cg18404041 chr3:52824283 ITIH1 -0.35 -6.17 -0.32 2.01e-9 Schizophrenia; CRC cis rs10504229 0.683 rs882429 chr8:58129292 A/G cg04204079 chr8:58130323 NA -0.45 -5.78 -0.3 1.71e-8 Developmental language disorder (linguistic errors); CRC cis rs6499255 0.951 rs78772829 chr16:69607098 G/A cg15192750 chr16:69999425 NA 0.56 7.54 0.38 4.67e-13 IgE levels; CRC cis rs10504229 0.683 rs903706 chr8:58128134 T/G cg05313129 chr8:58192883 C8orf71 -0.43 -6.11 -0.32 2.74e-9 Developmental language disorder (linguistic errors); CRC trans rs10504229 1.000 rs73607863 chr8:58170178 A/G cg04077850 chr5:125800366 GRAMD3 0.37 6.27 0.33 1.15e-9 Developmental language disorder (linguistic errors); CRC cis rs11650494 0.908 rs75904857 chr17:47370449 T/G cg08112188 chr17:47440006 ZNF652 1.18 10.8 0.51 1.72e-23 Prostate cancer; CRC cis rs6121246 0.559 rs1062794 chr20:30381758 G/C cg13852791 chr20:30311386 BCL2L1 0.8 15.85 0.66 1.91e-42 Mean corpuscular hemoglobin; CRC cis rs7945705 0.846 rs905290 chr11:8753729 A/G cg21881798 chr11:8931708 C11orf17;ST5 0.47 6.85 0.35 3.64e-11 Hemoglobin concentration; CRC trans rs10504229 0.953 rs59265461 chr8:58189701 A/T cg04077850 chr5:125800366 GRAMD3 0.37 6.27 0.33 1.15e-9 Developmental language disorder (linguistic errors); CRC cis rs853679 0.545 rs35949109 chr6:28025926 T/C cg03623178 chr6:28175578 NA 0.84 7.64 0.39 2.39e-13 Depression; CRC cis rs8014204 0.804 rs7154845 chr14:75247746 A/G cg03030879 chr14:75389066 RPS6KL1 -0.51 -8.02 -0.4 1.89e-14 Caffeine consumption; CRC cis rs2075371 0.932 rs2241332 chr7:133969439 A/G cg02659138 chr7:134003124 SLC35B4 0.38 6.31 0.33 9.12e-10 Mean platelet volume; CRC cis rs4073416 0.542 rs8017880 chr14:65942924 G/C cg03016385 chr14:66212404 NA -0.44 -6.1 -0.32 3.05e-9 N-glycan levels; CRC cis rs62229266 0.659 rs2835245 chr21:37416708 C/T cg12218747 chr21:37451666 NA -0.36 -6.16 -0.32 2.18e-9 Mitral valve prolapse; CRC cis rs140364877 1 rs140364877 chr7:1885178 C/T cg20295408 chr7:1910781 MAD1L1 -0.42 -6.11 -0.32 2.87e-9 Autism spectrum disorder or schizophrenia; CRC cis rs1005277 0.505 rs200939 chr10:38139483 T/C cg00409905 chr10:38381863 ZNF37A -0.63 -10.54 -0.5 1.44e-22 Extrinsic epigenetic age acceleration; CRC cis rs2204008 0.774 rs11615665 chr12:38328162 T/A cg13010199 chr12:38710504 ALG10B 0.45 6.01 0.31 5.04e-9 Bladder cancer; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg00026974 chr17:42298151 UBTF 0.44 7.0 0.36 1.44e-11 Liver disease severity in Alagille syndrome; CRC cis rs6762 0.550 rs8672 chr11:838634 C/G cg03885332 chr11:832357 CD151 -0.4 -5.93 -0.31 7.57e-9 Mean platelet volume; CRC cis rs883565 0.569 rs1274971 chr3:39161464 G/A cg01426195 chr3:39028469 NA -0.42 -7.0 -0.36 1.4e-11 Handedness; CRC cis rs9916302 0.904 rs4795357 chr17:37569551 T/C cg03013999 chr17:37608204 MED1 0.45 6.74 0.35 7.08e-11 Glomerular filtration rate (creatinine); CRC cis rs861020 0.630 rs655713 chr1:210006438 C/T cg05527609 chr1:210001259 C1orf107 0.77 10.66 0.51 5.37e-23 Orofacial clefts; CRC cis rs11764590 0.666 rs3996325 chr7:2053747 T/C cg24505167 chr7:1915268 MAD1L1 -0.37 -5.68 -0.3 2.9e-8 Neuroticism; CRC cis rs2516839 0.652 rs2516841 chr1:161010774 A/G cg11161846 chr1:160990452 F11R -0.49 -7.36 -0.38 1.48e-12 Granulocyte percentage of myeloid white cells; CRC cis rs10751667 0.666 rs10902247 chr11:953686 G/A cg06064525 chr11:970664 AP2A2 -0.31 -6.28 -0.33 1.07e-9 Alzheimer's disease (late onset); CRC cis rs10791097 0.690 rs12284540 chr11:130729772 T/C cg12179176 chr11:130786555 SNX19 0.68 11.03 0.52 2.76e-24 Autism spectrum disorder or schizophrenia;Schizophrenia; CRC cis rs1656402 1.000 rs2077929 chr2:233425738 G/A cg03852847 chr2:233439513 NA 0.45 7.71 0.39 1.54e-13 Non-small cell lung cancer (survival); CRC cis rs9309711 0.623 rs4641971 chr2:3481857 A/C cg15541040 chr2:3486749 NA 0.5 7.85 0.4 5.97e-14 Neurofibrillary tangles; CRC cis rs7605827 0.930 rs4668445 chr2:15515838 C/T cg19274914 chr2:15703543 NA 0.38 5.74 0.3 2.13e-8 Educational attainment (years of education); CRC cis rs4332037 0.722 rs4719332 chr7:1914681 G/A cg25834613 chr7:1915315 MAD1L1 -0.5 -7.78 -0.39 9.28e-14 Bipolar disorder; CRC cis rs172166 0.611 rs203883 chr6:28078356 A/G cg20615401 chr6:28092323 ZSCAN16 0.45 5.9 0.31 9.1e-9 Cardiac Troponin-T levels; CRC cis rs11955398 0.625 rs6874072 chr5:59987682 C/G cg02684056 chr5:59996105 DEPDC1B 0.4 5.84 0.31 1.23e-8 Intelligence (multi-trait analysis); CRC cis rs6123683 0.964 rs6127983 chr20:55824475 T/C cg13236649 chr20:55835020 BMP7 0.43 6.14 0.32 2.4e-9 Facial morphology (factor 5, width of mouth relative to central midface); CRC cis rs2153535 0.584 rs62395677 chr6:8371589 G/A cg07606381 chr6:8435919 SLC35B3 -0.64 -9.92 -0.48 1.82e-20 Motion sickness; CRC cis rs1707322 0.717 rs3014237 chr1:46090252 A/G cg03146154 chr1:46216737 IPP -0.67 -9.44 -0.46 7.06e-19 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs2404602 0.716 rs4886813 chr15:76838221 C/T cg22467129 chr15:76604101 ETFA 0.38 6.39 0.33 5.72e-10 Blood metabolite levels; CRC trans rs3942852 0.915 rs905477 chr11:48148606 T/C cg03929089 chr4:120376271 NA -0.61 -7.44 -0.38 9.12e-13 Acute lymphoblastic leukemia (childhood); CRC cis rs763121 0.889 rs1043402 chr22:38879688 G/A cg06544989 chr22:39130855 UNC84B 0.44 6.51 0.34 2.8e-10 Menopause (age at onset); CRC cis rs2153535 0.607 rs9502722 chr6:8541483 C/T cg07606381 chr6:8435919 SLC35B3 0.68 11.11 0.52 1.46e-24 Motion sickness; CRC cis rs9826463 0.582 rs73238176 chr3:142114256 G/A cg20824294 chr3:142316082 PLS1 0.37 5.88 0.31 1.03e-8 QRS duration in Tripanosoma cruzi seropositivity; CRC cis rs4481887 1.000 rs4372295 chr1:248464871 G/T cg00666640 chr1:248458726 OR2T12 0.52 9.37 0.46 1.17e-18 Common traits (Other); CRC cis rs936229 0.651 rs12908814 chr15:75132490 C/G cg09165964 chr15:75287851 SCAMP5 0.43 6.6 0.34 1.65e-10 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); CRC cis rs1707322 0.752 rs7529699 chr1:46134634 C/T cg03146154 chr1:46216737 IPP 0.66 9.65 0.47 1.44e-19 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs1728785 1.000 rs698717 chr16:68560199 A/G cg02972257 chr16:68554789 NA -0.61 -6.93 -0.36 2.22e-11 Ulcerative colitis; CRC cis rs911555 0.755 rs1138400 chr14:103956833 A/G cg12935359 chr14:103987150 CKB -0.55 -9.17 -0.45 5.26e-18 Intelligence (multi-trait analysis); CRC cis rs7274811 0.744 rs6120316 chr20:32177079 T/C cg03904042 chr20:32255491 NECAB3;C20orf134 -0.46 -6.32 -0.33 8.3e-10 Height; CRC cis rs10848704 0.956 rs10848703 chr12:2882250 C/T cg19995117 chr12:2880862 NA 0.47 8.36 0.42 1.79e-15 Quantitative traits; CRC cis rs9527 0.662 rs743575 chr10:104594906 T/G cg23093090 chr10:104574429 C10orf26 -0.4 -5.7 -0.3 2.7e-8 Arsenic metabolism; CRC cis rs4969178 0.930 rs7208596 chr17:76396528 C/G cg05887092 chr17:76393375 PGS1 0.55 10.0 0.48 1.01e-20 HDL cholesterol levels; CRC cis rs12188164 0.965 rs11743639 chr5:450710 C/T cg21972741 chr5:435613 AHRR 0.55 7.56 0.38 4.15e-13 Cystic fibrosis severity; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg06247172 chr6:34216481 C6orf1 0.44 6.36 0.33 6.75e-10 Intelligence (multi-trait analysis); CRC cis rs12477438 0.501 rs6727749 chr2:99793590 C/T cg14399236 chr2:99771627 LIPT1;TSGA10 0.73 12.17 0.56 2.24e-28 Chronic sinus infection; CRC cis rs4588572 0.643 rs1864173 chr5:77691158 C/T cg11547950 chr5:77652471 NA 0.54 7.5 0.38 6.18e-13 Triglycerides; CRC cis rs896854 0.654 rs28716845 chr8:95974485 A/G cg23172400 chr8:95962367 TP53INP1 -0.49 -8.19 -0.41 5.96e-15 Type 2 diabetes; CRC cis rs8067545 0.611 rs12949481 chr17:20190974 C/A cg13482628 chr17:19912719 NA -0.49 -7.8 -0.39 8.46e-14 Schizophrenia; CRC cis rs7845219 0.544 rs4570121 chr8:95917088 C/T cg16049864 chr8:95962084 TP53INP1 -0.44 -6.76 -0.35 6.34e-11 Type 2 diabetes; CRC cis rs1499614 1.000 rs1638731 chr7:66144679 C/T cg12463550 chr7:65579703 CRCP 0.65 5.91 0.31 8.34e-9 Gout; CRC cis rs2836974 0.568 rs8130795 chr21:40549983 T/A cg11890956 chr21:40555474 PSMG1 0.87 14.34 0.62 1.4e-36 Cognitive function; CRC cis rs10876993 0.928 rs1689587 chr12:58075398 A/G cg15848620 chr12:58087721 OS9 -0.65 -9.21 -0.45 3.84e-18 Celiac disease or Rheumatoid arthritis; CRC cis rs2294693 0.679 rs12200923 chr6:40970092 T/G cg14769373 chr6:40998127 UNC5CL -0.46 -5.62 -0.3 4.06e-8 Gastric cancer;Non-cardia gastric cancer; CRC cis rs910316 0.934 rs8006587 chr14:75664939 A/G cg11812906 chr14:75593930 NEK9 0.52 7.96 0.4 2.85e-14 Height; CRC cis rs3736485 0.966 rs8040080 chr15:51904459 C/T cg08986416 chr15:51914746 DMXL2 -0.47 -6.65 -0.34 1.22e-10 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC trans rs2727020 0.636 rs11040368 chr11:49453602 C/A cg03929089 chr4:120376271 NA -0.88 -16.45 -0.67 8.44e-45 Coronary artery disease; CRC cis rs3736594 0.802 rs9678824 chr2:27964328 G/C cg27432699 chr2:27873401 GPN1 0.59 7.69 0.39 1.73e-13 Fasting blood glucose;Fasting blood glucose (BMI interaction); CRC cis rs6429082 0.818 rs453315 chr1:235680585 C/T cg26050004 chr1:235667680 B3GALNT2 0.57 7.84 0.4 6.45e-14 Adiposity; CRC cis rs1799949 1.000 rs8176233 chr17:41219804 T/C cg05368731 chr17:41323189 NBR1 0.68 10.22 0.49 1.81e-21 Menopause (age at onset); CRC cis rs6500395 1.000 rs9933976 chr16:48590145 A/G cg04672837 chr16:48644449 N4BP1 0.45 6.66 0.34 1.18e-10 Response to tocilizumab in rheumatoid arthritis; CRC cis rs7959452 0.640 rs4274230 chr12:69700772 T/G cg22834771 chr12:69754056 YEATS4 -0.4 -5.75 -0.3 2.05e-8 Blood protein levels; CRC cis rs6743226 0.811 rs12471975 chr2:242154849 C/T cg10021735 chr2:242295487 FARP2 0.44 6.43 0.33 4.47e-10 Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI in non-smokers; CRC cis rs870825 0.616 rs6419939 chr4:185642869 C/T cg04058563 chr4:185651563 MLF1IP 0.72 9.42 0.46 8.15e-19 Blood protein levels; CRC cis rs780096 0.526 rs10182937 chr2:27651693 T/C cg27432699 chr2:27873401 GPN1 -0.5 -7.66 -0.39 2.06e-13 Total body bone mineral density; CRC cis rs12477438 0.798 rs13409996 chr2:99575497 C/T cg14399236 chr2:99771627 LIPT1;TSGA10 -0.7 -9.74 -0.47 7.45e-20 Chronic sinus infection; CRC cis rs7949030 0.626 rs1061093 chr11:62334908 G/C cg11742103 chr11:62369870 EML3;MTA2 0.62 11.79 0.54 5.33e-27 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; CRC cis rs35110281 0.667 rs2070533 chr21:45122753 G/A cg04455712 chr21:45112962 RRP1B 0.4 7.66 0.39 2.05e-13 Mean corpuscular volume; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg18728606 chr19:2050773 MKNK2 0.45 6.12 0.32 2.64e-9 Anxiety disorder; CRC cis rs853679 0.517 rs9357065 chr6:28129580 T/C cg12273811 chr6:28175739 NA 0.74 9.25 0.45 2.82e-18 Depression; CRC cis rs853679 0.517 rs4713146 chr6:28111536 A/T cg06470822 chr6:28175283 NA 1.03 13.59 0.6 1.04e-33 Depression; CRC cis rs3733585 0.624 rs7376154 chr4:9952587 C/A cg11266682 chr4:10021025 SLC2A9 -0.47 -9.62 -0.47 1.76e-19 Cleft plate (environmental tobacco smoke interaction); CRC cis rs6546324 0.625 rs2861700 chr2:67855441 A/G cg15745817 chr2:67799979 NA 0.57 9.72 0.47 8.44e-20 Endometriosis; CRC cis rs6459788 0.693 rs11981578 chr7:157250133 C/T cg03453431 chr7:157225567 NA -0.56 -8.73 -0.43 1.32e-16 Epstein-Barr virus copy number in lymphoblastoid cell lines; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg23857200 chr19:39882127 MED29;PAF1 0.47 6.02 0.31 4.72e-9 Anxiety disorder; CRC cis rs9443645 0.901 rs9352669 chr6:79584141 T/G cg09184832 chr6:79620586 NA -0.5 -9.44 -0.46 7.24e-19 Intelligence (multi-trait analysis); CRC cis rs17711722 0.523 rs365896 chr7:65510697 A/G cg07294406 chr7:64700536 NA -0.38 -6.33 -0.33 7.88e-10 Calcium levels; CRC cis rs9527 0.590 rs11191513 chr10:104772984 T/G cg15744005 chr10:104629667 AS3MT -0.29 -5.89 -0.31 9.32e-9 Arsenic metabolism; CRC cis rs6685188 0.920 rs6676110 chr1:205662977 G/A cg11965913 chr1:205819406 PM20D1 -0.47 -6.78 -0.35 5.55e-11 White blood cell count (basophil);Basophil percentage of white cells; CRC cis rs9322193 0.923 rs4870529 chr6:150037572 A/G cg00933542 chr6:150070202 PCMT1 0.3 6.26 0.33 1.17e-9 Lung cancer; CRC cis rs9467773 1.000 rs9467782 chr6:26542773 G/A cg09904177 chr6:26538194 HMGN4 0.85 14.88 0.63 1.17e-38 Intelligence (multi-trait analysis); CRC cis rs1580019 0.961 rs3801328 chr7:32496930 T/C cg07520158 chr7:32535189 LSM5;AVL9 0.45 6.48 0.34 3.4e-10 Cognitive ability; CRC cis rs13191362 0.872 rs13194619 chr6:163203657 C/T cg06582575 chr6:163149167 PACRG;PARK2 0.91 11.49 0.53 6.66e-26 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs12580194 0.593 rs66902680 chr12:55724080 A/C cg19537932 chr12:55886519 OR6C68 -0.7 -8.81 -0.44 7.51e-17 Cancer; CRC cis rs763121 0.853 rs2076028 chr22:39150450 G/A cg06022373 chr22:39101656 GTPBP1 0.79 12.03 0.55 7.09e-28 Menopause (age at onset); CRC cis rs2857891 0.909 rs17191140 chr11:6944283 G/A cg12728517 chr11:6947552 ZNF215 0.56 5.95 0.31 6.96e-9 Response to cytadine analogues (cytosine arabinoside); CRC cis rs10504229 1.000 rs79561699 chr8:58170601 A/G cg02290350 chr8:58132656 NA -0.44 -6.41 -0.33 4.95e-10 Developmental language disorder (linguistic errors); CRC trans rs2243480 1.000 rs10807702 chr7:65767843 C/T cg10756647 chr7:56101905 PSPH 0.68 7.0 0.36 1.46e-11 Diabetic kidney disease; CRC cis rs1865760 0.566 rs9379825 chr6:26083871 C/A cg18357526 chr6:26021779 HIST1H4A 0.41 5.83 0.31 1.32e-8 Height; CRC cis rs172166 0.516 rs2791333 chr6:28111114 A/G cg15845792 chr6:28175446 NA 0.64 9.61 0.47 1.9e-19 Cardiac Troponin-T levels; CRC cis rs7829975 0.807 rs519019 chr8:8595104 A/T cg08975724 chr8:8085496 FLJ10661 -0.44 -6.82 -0.35 4.51e-11 Mood instability; CRC cis rs1728785 1.000 rs7195979 chr16:68586801 G/A cg02972257 chr16:68554789 NA -0.64 -7.52 -0.38 5.13e-13 Ulcerative colitis; CRC trans rs9650657 0.513 rs4841459 chr8:10782442 A/C cg06636001 chr8:8085503 FLJ10661 -0.64 -9.37 -0.46 1.19e-18 Neuroticism; CRC cis rs2288073 0.965 rs10199334 chr2:24392618 T/C cg06627628 chr2:24431161 ITSN2 -0.72 -9.72 -0.47 8.27e-20 Venous thromboembolism (SNP x SNP interaction); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg05402854 chr6:111408840 SLC16A10 0.33 6.25 0.33 1.25e-9 Liver disease severity in Alagille syndrome; CRC cis rs10751667 0.666 rs7396473 chr11:966181 T/C cg06064525 chr11:970664 AP2A2 -0.3 -6.11 -0.32 2.78e-9 Alzheimer's disease (late onset); CRC cis rs13096480 0.583 rs17598137 chr3:49891362 G/T cg07859876 chr3:50654386 MAPKAPK3 0.46 6.82 0.35 4.48e-11 Intelligence (multi-trait analysis); CRC cis rs6120849 0.586 rs2025096 chr20:33540000 G/A cg08999081 chr20:33150536 PIGU 0.43 5.69 0.3 2.76e-8 Protein C levels; CRC cis rs11098499 0.909 rs11723757 chr4:120299669 C/T cg09307838 chr4:120376055 NA 0.7 10.76 0.51 2.47e-23 Corneal astigmatism; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg25057861 chr10:72142518 LRRC20 0.43 6.76 0.35 6.29e-11 Liver disease severity in Alagille syndrome; CRC cis rs2836974 0.533 rs4817999 chr21:40554355 C/A cg06238570 chr21:40685208 BRWD1 -0.8 -12.79 -0.58 1.12e-30 Cognitive function; CRC cis rs2836950 0.545 rs2836956 chr21:40623018 C/G cg06238570 chr21:40685208 BRWD1 0.62 8.95 0.44 2.63e-17 Menarche (age at onset); CRC trans rs1656966 1.000 rs1656966 chr3:186466252 C/T cg09477292 chr4:6577027 MAN2B2 0.41 6.12 0.32 2.73e-9 Myopia (pathological); CRC cis rs9811920 0.609 rs812657 chr3:99566329 T/C cg07805332 chr3:99536008 MIR548G;C3orf26 0.51 7.72 0.39 1.38e-13 Axial length; CRC cis rs12519773 0.534 rs2453763 chr5:92376460 T/A cg18783429 chr5:92414398 NA -0.34 -7.23 -0.37 3.51e-12 Migraine; CRC cis rs67340775 0.541 rs200975 chr6:27855625 G/T cg25164649 chr6:28176230 NA 0.59 6.01 0.31 5.06e-9 Lung cancer in ever smokers; CRC cis rs950169 0.845 rs4502182 chr15:84923520 A/G cg17507749 chr15:85114479 UBE2QP1 0.75 10.94 0.52 5.76e-24 Schizophrenia; CRC cis rs8072100 0.840 rs2136751 chr17:45456093 A/G cg25173405 chr17:45401733 C17orf57 -0.51 -8.23 -0.41 4.3e-15 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs4073582 0.595 rs801734 chr11:65931216 T/C cg14036092 chr11:66035641 RAB1B 0.54 8.74 0.43 1.24e-16 Gout; CRC cis rs10450586 0.863 rs1478690 chr11:27295878 A/G cg10370305 chr11:27303972 NA -0.38 -6.25 -0.33 1.29e-9 Total body bone mineral density; CRC cis rs9522267 0.535 rs9522299 chr13:112236013 C/A cg26182253 chr13:112236782 NA 0.31 6.33 0.33 7.97e-10 Hepatitis; CRC cis rs1008375 0.898 rs61047804 chr4:17593965 G/A cg16339924 chr4:17578868 LAP3 0.58 7.73 0.39 1.36e-13 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs427394 0.659 rs274693 chr5:6734162 G/A cg15145174 chr5:6755386 POLS -0.46 -6.78 -0.35 5.53e-11 Menopause (age at onset); CRC cis rs17270561 0.779 rs17271767 chr6:25886921 C/T cg16482183 chr6:26056742 HIST1H1C 0.85 11.1 0.52 1.52e-24 Iron status biomarkers; CRC cis rs11098499 0.863 rs11723090 chr4:120490592 T/C cg09307838 chr4:120376055 NA 0.71 10.46 0.5 2.62e-22 Corneal astigmatism; CRC cis rs6570726 0.764 rs366673 chr6:145814628 T/A cg23711669 chr6:146136114 FBXO30 0.74 12.96 0.58 2.47e-31 Lobe attachment (rater-scored or self-reported); CRC cis rs1218582 0.772 rs4845400 chr1:154872523 C/T cg24250549 chr1:154909240 PMVK 0.65 11.16 0.52 9.75e-25 Prostate cancer; CRC cis rs7640424 0.589 rs78673584 chr3:107813133 A/G cg09227934 chr3:107805635 CD47 -0.51 -6.41 -0.33 5.01e-10 Body mass index; CRC cis rs12541635 0.932 rs1835267 chr8:107044435 C/T cg10147462 chr8:107024639 NA 0.46 7.75 0.39 1.19e-13 Age of smoking initiation; CRC cis rs10540 1.000 rs35255804 chr11:492617 G/A cg03934478 chr11:495069 RNH1 0.69 7.73 0.39 1.28e-13 Body mass index; CRC trans rs3942852 0.955 rs1532754 chr11:48115279 A/T cg15704280 chr7:45808275 SEPT13 -0.62 -7.31 -0.37 2.09e-12 Acute lymphoblastic leukemia (childhood); CRC trans rs8123881 0.733 rs7268466 chr20:15810676 C/T cg02073511 chr16:3550924 CLUAP1 0.51 6.03 0.32 4.47e-9 Body mass index; CRC cis rs12134245 0.874 rs17501937 chr1:92021705 C/T cg07090678 chr1:91966139 CDC7 -0.36 -5.63 -0.3 3.9e-8 Breast cancer; CRC trans rs2084898 0.891 rs501021 chr11:120000872 T/C cg10387956 chr15:72646210 HEXA 0.68 6.27 0.33 1.12e-9 Stroke (pediatric); CRC cis rs34929064 0.536 rs2961279 chr7:22638154 T/C cg26061582 chr7:22766209 IL6 -0.38 -5.61 -0.3 4.26e-8 Major depression and alcohol dependence; CRC cis rs13631 0.894 rs7856589 chr9:140003921 A/G cg15396367 chr9:139972779 UAP1L1 -0.4 -6.14 -0.32 2.44e-9 Cerebrospinal fluid biomarker levels; CRC cis rs4272321 1 rs4272321 chr7:157951835 A/G cg27194152 chr7:157982427 PTPRN2 0.38 5.94 0.31 7.26e-9 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; CRC cis rs12580194 0.593 rs7313465 chr12:55736863 C/T cg23425280 chr12:56401806 NA 0.47 6.02 0.31 4.68e-9 Cancer; CRC cis rs7914558 1.000 rs4917996 chr10:104925829 A/C cg15744005 chr10:104629667 AS3MT -0.34 -7.32 -0.37 1.97e-12 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs7618915 0.547 rs4130905 chr3:52709831 A/T cg18404041 chr3:52824283 ITIH1 -0.44 -9.03 -0.45 1.49e-17 Bipolar disorder; CRC cis rs7811142 0.830 rs3087502 chr7:99955364 G/A cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.94 12.66 0.57 3.42e-30 Platelet count; CRC cis rs736408 0.609 rs13061423 chr3:52790213 T/C cg05573699 chr3:52720067 GNL3;PBRM1 -0.46 -6.57 -0.34 1.96e-10 Bipolar disorder; CRC cis rs28386778 0.897 rs1062791 chr17:61896487 C/T cg07362569 chr17:61921086 SMARCD2 0.38 5.96 0.31 6.6e-9 Prudent dietary pattern; CRC cis rs13191362 1.000 rs34655790 chr6:163202739 G/A cg21926612 chr6:163149169 PACRG;PARK2 0.92 12.01 0.55 8.28e-28 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg14514618 chr14:68171536 RDH12 0.42 6.04 0.32 4.18e-9 Intelligence (multi-trait analysis); CRC cis rs1448094 0.817 rs12370270 chr12:86343303 T/G cg02569458 chr12:86230093 RASSF9 0.46 7.85 0.4 6.05e-14 Major depressive disorder; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg00366814 chr2:75061219 HK2 -0.41 -6.25 -0.33 1.29e-9 Myopia (pathological); CRC cis rs9287719 0.967 rs10929686 chr2:10743705 A/C cg00105475 chr2:10696890 NA 0.45 7.3 0.37 2.19e-12 Prostate cancer; CRC cis rs6502050 0.835 rs4789677 chr17:80119842 A/G cg13198984 chr17:80129470 CCDC57 0.47 8.35 0.42 1.88e-15 Life satisfaction; CRC cis rs7044106 0.708 rs1324472 chr9:123375110 C/T cg09419670 chr9:123605666 PSMD5;LOC253039 0.56 8.51 0.42 6.3e-16 Hip circumference adjusted for BMI; CRC cis rs832540 0.656 rs832567 chr5:56152416 C/A cg20203395 chr5:56204925 C5orf35 -0.46 -6.35 -0.33 7.36e-10 Coronary artery disease; CRC cis rs367615 0.552 rs2963022 chr5:108727185 A/G cg17395555 chr5:108820864 NA -0.37 -7.02 -0.36 1.31e-11 Colorectal cancer (SNP x SNP interaction); CRC cis rs35849525 0.814 rs7635601 chr3:50044006 A/T cg05623727 chr3:50126028 RBM5 0.52 6.75 0.35 6.83e-11 Intelligence (multi-trait analysis); CRC cis rs7618915 0.501 rs35526119 chr3:52749334 C/T cg18099408 chr3:52552593 STAB1 -0.46 -7.71 -0.39 1.48e-13 Bipolar disorder; CRC trans rs11039798 0.544 rs114343057 chr11:48558172 C/T cg15704280 chr7:45808275 SEPT13 0.66 6.79 0.35 5.21e-11 Axial length; CRC cis rs4076764 0.846 rs10753616 chr1:163415855 G/T cg24596788 chr1:163392923 NA 0.62 10.19 0.49 2.32e-21 Motion sickness; CRC cis rs59901009 0.569 rs12280005 chr11:10228452 G/A cg23875677 chr11:10229755 SBF2 -0.53 -5.97 -0.31 6.29e-9 Hematocrit;Hemoglobin concentration; CRC cis rs2019137 0.560 rs6707386 chr2:113981022 G/A cg07772999 chr2:113993052 PAX8;LOC440839;LOC654433 0.58 8.48 0.42 7.69e-16 Lymphocyte counts; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg06975499 chr17:40896881 EZH1 0.44 6.34 0.33 7.56e-10 Intelligence (multi-trait analysis); CRC cis rs4363385 0.574 rs6671520 chr1:152944156 C/T cg25856811 chr1:152973957 SPRR3 -0.25 -6.6 -0.34 1.64e-10 Inflammatory skin disease; CRC cis rs3736485 0.789 rs11070857 chr15:51857220 C/T cg08986416 chr15:51914746 DMXL2 -0.44 -6.1 -0.32 3e-9 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs921968 0.643 rs711186 chr2:219346102 A/G cg02176678 chr2:219576539 TTLL4 -0.49 -8.1 -0.41 1.11e-14 Mean corpuscular hemoglobin concentration; CRC cis rs11229555 0.645 rs36002376 chr11:58204809 C/G cg15696309 chr11:58395628 NA -0.9 -11.45 -0.53 8.8e-26 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; CRC cis rs4660214 0.666 rs950805 chr1:39705458 A/C cg11070191 chr1:39582205 MACF1 0.36 5.61 0.3 4.37e-8 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs2739330 0.587 rs4820571 chr22:24242973 A/G cg04234412 chr22:24373322 LOC391322 -0.63 -9.6 -0.47 2.1e-19 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs9487051 0.676 rs13210693 chr6:109598964 A/G cg21918786 chr6:109611834 NA 0.38 6.56 0.34 2.1e-10 Reticulocyte fraction of red cells; CRC cis rs4363385 0.530 rs10888529 chr1:153050654 G/T cg25856811 chr1:152973957 SPRR3 -0.21 -5.77 -0.3 1.81e-8 Inflammatory skin disease; CRC cis rs950169 0.579 rs62027818 chr15:84661145 T/C cg11189052 chr15:85197271 WDR73 0.55 7.38 0.38 1.28e-12 Schizophrenia; CRC cis rs6963495 0.818 rs73190161 chr7:105156871 C/T cg13798780 chr7:105162888 PUS7 0.68 8.08 0.41 1.27e-14 Bipolar disorder (body mass index interaction); CRC cis rs1891275 0.515 rs2153653 chr10:93495926 T/A cg07889827 chr10:93443413 NA -0.4 -6.61 -0.34 1.53e-10 Intelligence (multi-trait analysis); CRC cis rs4972806 0.849 rs1542180 chr2:177028767 C/T cg10305451 chr2:177043427 NA 0.72 11.29 0.53 3.29e-25 IgG glycosylation; CRC cis rs853679 0.517 rs9295761 chr6:28147987 A/G cg02631126 chr6:28058918 ZSCAN12L1 0.28 5.68 0.3 2.95e-8 Depression; CRC cis rs1218582 0.741 rs10908446 chr1:154869559 G/A cg09359103 chr1:154839909 KCNN3 -0.71 -12.54 -0.57 9.61e-30 Prostate cancer; CRC cis rs10504229 1.000 rs72650899 chr8:58180525 G/T cg02290350 chr8:58132656 NA -0.42 -5.96 -0.31 6.62e-9 Developmental language disorder (linguistic errors); CRC cis rs9368481 1.000 rs9368481 chr6:26961761 C/T cg10547057 chr6:26987810 LOC100270746;C6orf41 -0.41 -5.74 -0.3 2.12e-8 Autism spectrum disorder or schizophrenia; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg16004800 chr12:4758496 NDUFA9 0.44 6.28 0.33 1.06e-9 Response to antipsychotic treatment; CRC cis rs12908161 1.000 rs12908549 chr15:85322351 C/G cg17507749 chr15:85114479 UBE2QP1 0.62 8.93 0.44 3.03e-17 Schizophrenia; CRC cis rs2737618 0.698 rs2737678 chr1:200088041 C/T cg21825944 chr1:200113062 NR5A2 -0.5 -6.94 -0.36 2.09e-11 Uric acid levels; CRC cis rs7945705 0.902 rs1560569 chr11:8939887 C/T cg00186954 chr11:8933980 ST5;C11orf17 -0.44 -6.99 -0.36 1.54e-11 Hemoglobin concentration; CRC trans rs8002861 0.905 rs6561149 chr13:44456782 T/G cg12856521 chr11:46389249 DGKZ -0.43 -6.73 -0.35 7.69e-11 Leprosy; CRC cis rs11971779 0.793 rs11543827 chr7:139032693 G/A cg07862535 chr7:139043722 LUC7L2 0.79 10.33 0.49 7.52e-22 Diisocyanate-induced asthma; CRC cis rs12497850 0.897 rs6446252 chr3:48911125 C/T cg07636037 chr3:49044803 WDR6 1.03 18.15 0.71 1.69e-51 Parkinson's disease; CRC cis rs870825 0.616 rs2090590 chr4:185647850 A/C cg04058563 chr4:185651563 MLF1IP 0.72 9.3 0.46 2.04e-18 Blood protein levels; CRC cis rs9311474 1.000 rs7614727 chr3:52295895 C/T cg08222913 chr3:52553049 STAB1 -0.35 -6.56 -0.34 2.04e-10 Electroencephalogram traits; CRC cis rs6541297 1.000 rs6686054 chr1:230282853 C/T cg20703242 chr1:230279135 GALNT2 0.51 8.01 0.4 2.05e-14 Coronary artery disease; CRC cis rs6582630 0.502 rs11181214 chr12:38298313 C/A cg26384229 chr12:38710491 ALG10B 0.69 9.74 0.47 7.18e-20 Drug-induced liver injury (flucloxacillin); CRC cis rs4889855 0.505 rs4890057 chr17:78591679 A/G cg16591659 chr17:78472290 NA -0.43 -6.13 -0.32 2.53e-9 Fractional excretion of uric acid; CRC cis rs9916302 0.904 rs4239222 chr17:37696235 A/C cg07936489 chr17:37558343 FBXL20 0.83 13.05 0.58 1.21e-31 Glomerular filtration rate (creatinine); CRC cis rs6120849 0.663 rs11698868 chr20:33549946 C/T cg08999081 chr20:33150536 PIGU 0.44 5.73 0.3 2.22e-8 Protein C levels; CRC trans rs3780486 0.505 rs1411609 chr9:33137303 C/T cg20290983 chr6:43655470 MRPS18A 0.96 16.87 0.68 1.95e-46 IgG glycosylation; CRC cis rs2204008 0.774 rs12810027 chr12:38212165 A/G cg26384229 chr12:38710491 ALG10B 0.69 9.26 0.45 2.81e-18 Bladder cancer; CRC cis rs1552244 0.572 rs2054478 chr3:10172211 C/T cg13047869 chr3:10149882 C3orf24 0.55 6.66 0.34 1.17e-10 Alzheimer's disease; CRC cis rs4713118 0.615 rs57252182 chr6:27720249 C/A cg03623178 chr6:28175578 NA 0.61 8.65 0.43 2.37e-16 Parkinson's disease; CRC cis rs13118159 0.836 rs2276903 chr4:1343405 A/G cg19318889 chr4:1322082 MAEA 0.48 7.16 0.37 5.18e-12 Longevity; CRC cis rs3026101 0.697 rs2107152 chr17:5297350 A/G cg25236894 chr17:5323110 RPAIN;NUP88 0.42 6.84 0.35 3.98e-11 Body mass index; CRC cis rs992157 0.730 rs2891078 chr2:219184432 C/T cg04880052 chr2:219191631 PNKD 0.4 6.08 0.32 3.32e-9 Colorectal cancer; CRC cis rs798554 0.836 rs798490 chr7:2801542 C/T cg13628971 chr7:2884303 GNA12 0.55 7.42 0.38 1.03e-12 Height; CRC cis rs4481887 0.676 rs1544177 chr1:248524683 C/G cg26353448 chr1:248524236 OR2T4 -0.35 -7.19 -0.37 4.3e-12 Common traits (Other); CRC cis rs4319547 0.737 rs10846920 chr12:122943231 C/T cg05707623 chr12:122985044 ZCCHC8 -0.56 -7.32 -0.37 1.88e-12 Body mass index; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg14927277 chr11:28129967 METT5D1;KIF18A 0.5 7.2 0.37 4.09e-12 Response to antipsychotic treatment; CRC cis rs2180341 1.000 rs7756336 chr6:127650299 T/C cg24812749 chr6:127587940 RNF146 0.95 13.72 0.6 3.35e-34 Breast cancer; CRC cis rs59104589 0.521 rs60988810 chr2:242430084 C/A cg19488206 chr2:242435732 STK25 0.43 6.92 0.36 2.31e-11 Fibrinogen levels; CRC cis rs769267 0.965 rs12460764 chr19:19431963 G/T cg03709012 chr19:19516395 GATAD2A -0.68 -10.4 -0.5 4.29e-22 Tonsillectomy; CRC cis rs875971 0.862 rs10282433 chr7:65721439 G/A cg12463550 chr7:65579703 CRCP -0.52 -7.23 -0.37 3.44e-12 Aortic root size; CRC trans rs9929218 0.911 rs1075959 chr16:68832750 A/G cg04657470 chr2:198365150 HSPE1;HSPD1 -0.8 -11.34 -0.53 2.17e-25 Colorectal cancer; CRC cis rs4481887 0.830 rs6686474 chr1:248477116 A/C cg13385794 chr1:248469461 NA 0.38 6.67 0.35 1.09e-10 Common traits (Other); CRC cis rs12476592 0.602 rs262533 chr2:63906048 C/G cg10828910 chr2:63850056 LOC388955 0.52 6.39 0.33 5.59e-10 Childhood ear infection; CRC cis rs1865760 0.566 rs9358902 chr6:26058570 C/G cg16482183 chr6:26056742 HIST1H1C 0.52 7.54 0.38 4.58e-13 Height; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg06452647 chr12:49961750 MCRS1 0.45 6.4 0.33 5.5e-10 Response to antipsychotic treatment; CRC cis rs7044106 0.708 rs10760113 chr9:123474050 T/C cg09419670 chr9:123605666 PSMD5;LOC253039 0.72 11.63 0.54 2.04e-26 Hip circumference adjusted for BMI; CRC cis rs3087591 1.000 rs2040791 chr17:29627297 G/C cg24425628 chr17:29625626 OMG;NF1 -0.88 -16.49 -0.67 5.77e-45 Hip circumference; CRC cis rs7707921 0.958 rs6452447 chr5:81482522 A/G cg17942617 chr5:81327376 ATG10 -0.4 -5.94 -0.31 7.22e-9 Breast cancer; CRC cis rs2976388 0.590 rs11785290 chr8:143814849 A/G cg20041105 chr8:143859282 LYNX1 -0.42 -6.98 -0.36 1.66e-11 Urinary tract infection frequency; CRC cis rs6541297 0.941 rs2180078 chr1:230280513 T/C cg20703242 chr1:230279135 GALNT2 0.52 7.7 0.39 1.58e-13 Coronary artery disease; CRC cis rs10504229 0.724 rs16922734 chr8:58111192 C/T cg05313129 chr8:58192883 C8orf71 -0.42 -5.85 -0.31 1.16e-8 Developmental language disorder (linguistic errors); CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg05398773 chr8:71581521 XKR9;LACTB2 -0.45 -7.2 -0.37 4.11e-12 Myopia (pathological); CRC cis rs2832191 0.716 rs1888440 chr21:30454484 C/T cg24692254 chr21:30365293 RNF160 0.85 16.14 0.66 1.48e-43 Dental caries; CRC cis rs4594175 0.926 rs9323206 chr14:51621800 C/T cg23942311 chr14:51606299 NA 0.68 11.09 0.52 1.77e-24 Cancer; CRC cis rs6502050 0.835 rs6502065 chr17:80095642 T/C cg25804541 chr17:80189381 SLC16A3 -0.31 -5.97 -0.31 6.08e-9 Life satisfaction; CRC cis rs1552244 0.935 rs2272124 chr3:10138189 T/C cg08888203 chr3:10149979 C3orf24 0.67 9.75 0.47 6.71e-20 Alzheimer's disease; CRC cis rs10504229 0.595 rs79077737 chr8:58117520 G/A cg04204079 chr8:58130323 NA -0.46 -5.8 -0.3 1.57e-8 Developmental language disorder (linguistic errors); CRC cis rs68170813 0.559 rs3823959 chr7:107009379 T/G cg02696742 chr7:106810147 HBP1 -0.57 -6.22 -0.32 1.52e-9 Coronary artery disease; CRC cis rs7937682 0.961 rs11828343 chr11:111491322 A/G cg19812747 chr11:111475976 SIK2 0.54 8.39 0.42 1.49e-15 Primary sclerosing cholangitis; CRC cis rs55871839 0.708 rs10093993 chr8:59811454 T/C cg07426533 chr8:59803705 TOX -0.34 -5.94 -0.31 7.22e-9 Pneumonia; CRC cis rs6424115 0.964 rs2473375 chr1:24136545 C/T cg15997130 chr1:24165203 NA 0.77 11.8 0.55 4.75e-27 Immature fraction of reticulocytes; CRC cis rs2412459 1.000 rs8023482 chr15:40307095 A/C cg01081584 chr15:40268610 EIF2AK4 -0.73 -6.59 -0.34 1.72e-10 Response to haloperidol in psychosis; CRC cis rs1801251 0.963 rs7562712 chr2:233606580 A/G cg25237894 chr2:233734115 C2orf82 0.54 8.77 0.44 9.91e-17 Coronary artery disease; CRC cis rs5769765 0.773 rs9616382 chr22:50312979 C/T cg08270630 chr22:50330655 NA -0.4 -5.61 -0.3 4.4e-8 Schizophrenia; CRC trans rs13046373 0.905 rs4816372 chr21:32077414 A/T cg26898958 chr10:38383359 ZNF37A -0.42 -6.05 -0.32 3.87e-9 HDL cholesterol; CRC cis rs7258465 0.931 rs271626 chr19:18627067 C/T cg01065977 chr19:18549689 ISYNA1 0.37 5.72 0.3 2.36e-8 Breast cancer; CRC cis rs9992667 0.955 rs1000571 chr4:38662895 G/A cg19726192 chr4:38663646 FLJ13197 -0.71 -9.02 -0.45 1.62e-17 Eosinophil percentage of granulocytes; CRC cis rs6502050 0.835 rs35070385 chr17:80128447 G/A cg09264619 chr17:80180166 NA -0.34 -5.76 -0.3 1.93e-8 Life satisfaction; CRC cis rs11191270 0.590 rs12569901 chr10:104025410 C/G cg15320455 chr10:103880129 LDB1 0.75 6.96 0.36 1.91e-11 Intelligence (multi-trait analysis); CRC cis rs7909074 1.000 rs4948926 chr10:45392604 G/C cg04218760 chr10:45406644 TMEM72 -0.36 -10.38 -0.5 4.96e-22 Mean corpuscular volume; CRC cis rs12701220 0.520 rs7803208 chr7:1162084 C/T cg00990874 chr7:1149470 C7orf50 -0.56 -8.32 -0.42 2.43e-15 Bronchopulmonary dysplasia; CRC cis rs1552244 0.572 rs68013239 chr3:10165711 G/T cg10729496 chr3:10149963 C3orf24 0.48 5.61 0.3 4.19e-8 Alzheimer's disease; CRC trans rs9858542 0.953 rs6803222 chr3:49665976 T/G cg21582582 chr3:182698605 DCUN1D1 -0.53 -6.39 -0.33 5.65e-10 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs11122272 0.735 rs2355872 chr1:231478489 A/T cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.51 -7.41 -0.38 1.1e-12 Hemoglobin concentration; CRC cis rs17376456 0.877 rs7728736 chr5:93404277 C/T cg09848695 chr5:92956644 FAM172A;MIR2277 0.64 6.26 0.33 1.22e-9 Diabetic retinopathy; CRC cis rs4713118 0.629 rs149899 chr6:28019979 C/T cg23161317 chr6:28129485 ZNF389 0.43 5.71 0.3 2.46e-8 Parkinson's disease; CRC cis rs7827545 1.000 rs62523736 chr8:135560916 A/T cg13086574 chr8:135490821 ZFAT -0.36 -5.94 -0.31 7.21e-9 Hypertension (SNP x SNP interaction); CRC cis rs2303745 0.544 rs6512180 chr19:17399153 C/T cg04248312 chr19:17393744 ANKLE1 -0.97 -14.27 -0.62 2.6e-36 Systemic lupus erythematosus; CRC cis rs7772486 0.790 rs10223507 chr6:146285204 C/A cg23711669 chr6:146136114 FBXO30 -0.66 -10.97 -0.52 4.6e-24 Lobe attachment (rater-scored or self-reported); CRC cis rs11191205 0.686 rs10883668 chr10:103398834 G/A cg15320455 chr10:103880129 LDB1 0.56 6.19 0.32 1.77e-9 Intelligence (multi-trait analysis); CRC cis rs10504073 0.584 rs62507182 chr8:49942500 C/A cg00325661 chr8:49890786 NA 0.59 10.67 0.51 4.86e-23 Blood metabolite ratios; CRC cis rs17376456 0.569 rs11948511 chr5:93286601 A/C cg21475434 chr5:93447410 FAM172A -0.45 -6.36 -0.33 6.59e-10 Diabetic retinopathy; CRC cis rs4730250 0.654 rs6947857 chr7:106787266 T/G cg02696742 chr7:106810147 HBP1 0.58 6.68 0.35 1.02e-10 Osteoarthritis; CRC cis rs6762477 0.748 rs3755831 chr3:50228767 G/T cg24110177 chr3:50126178 RBM5 0.44 6.59 0.34 1.71e-10 Menarche (age at onset); CRC cis rs10489202 0.634 rs11582396 chr1:168077636 C/T cg24449463 chr1:168025552 DCAF6 -0.52 -7.3 -0.37 2.21e-12 Schizophrenia; CRC cis rs67478160 0.572 rs8016014 chr14:104293798 G/C cg01849466 chr14:104193079 ZFYVE21 -0.47 -8.02 -0.4 1.83e-14 Schizophrenia; CRC cis rs2033908 0.620 rs1440272 chr11:12852309 G/A cg25843174 chr11:12811716 TEAD1 -0.4 -7.01 -0.36 1.35e-11 Sitting height ratio; CRC cis rs6570726 0.935 rs387965 chr6:145869366 A/G cg23711669 chr6:146136114 FBXO30 0.71 12.3 0.56 7.07e-29 Lobe attachment (rater-scored or self-reported); CRC cis rs873946 0.586 rs12259688 chr10:134549628 A/G cg18305652 chr10:134549665 INPP5A 0.53 7.24 0.37 3.24e-12 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CRC cis rs6952808 0.717 rs12534679 chr7:1926745 G/A cg14004847 chr7:1930337 MAD1L1 -0.5 -7.58 -0.39 3.5e-13 Bipolar disorder and schizophrenia; CRC cis rs6951245 0.872 rs77434655 chr7:1098405 G/A cg21664854 chr7:1097933 C7orf50;GPR146 0.77 8.8 0.44 7.85e-17 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs3087591 1.000 rs2952982 chr17:29470646 A/C cg24425628 chr17:29625626 OMG;NF1 0.87 16.66 0.68 1.32e-45 Hip circumference; CRC cis rs853679 0.666 rs200956 chr6:27839746 A/G cg25164649 chr6:28176230 NA 0.5 5.77 0.3 1.88e-8 Depression; CRC cis rs7086627 0.515 rs11202960 chr10:82209807 G/A cg00277334 chr10:82204260 NA -0.84 -16.95 -0.68 9.58e-47 Post bronchodilator FEV1; CRC cis rs881375 0.967 rs7875829 chr9:123660398 A/G cg09419670 chr9:123605666 PSMD5;LOC253039 0.6 8.79 0.44 8.51e-17 Rheumatoid arthritis; CRC cis rs28830936 0.510 rs7174099 chr15:42099059 A/G cg17847044 chr15:42102381 MAPKBP1 -0.37 -8.95 -0.44 2.65e-17 Diastolic blood pressure; CRC cis rs9814567 1.000 rs7426847 chr3:134267519 A/G cg06541857 chr3:134203789 ANAPC13;CEP63 0.39 5.74 0.3 2.15e-8 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs2882667 1.000 rs2060222 chr5:138308466 C/T cg09476006 chr5:138032270 NA 0.44 7.15 0.37 5.63e-12 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs6860806 0.531 rs272888 chr5:131665423 T/C cg09877947 chr5:131593287 PDLIM4 0.43 7.07 0.36 9.52e-12 Breast cancer; CRC cis rs875971 0.862 rs10250544 chr7:65766561 A/G cg18876405 chr7:65276391 NA -0.53 -8.45 -0.42 9.32e-16 Aortic root size; CRC trans rs7395662 0.853 rs4882062 chr11:48453271 A/G cg21153622 chr11:89784906 NA 0.45 7.0 0.36 1.42e-11 HDL cholesterol; CRC cis rs12449964 0.524 rs4925093 chr17:17568946 G/T cg09796270 chr17:17721594 SREBF1 0.46 8.01 0.4 2.05e-14 Coronary artery disease or ischemic stroke; CRC cis rs796364 1.000 rs1509835 chr2:200814809 C/G cg12253985 chr2:200820533 C2orf60;C2orf47 0.55 6.04 0.32 4.06e-9 Schizophrenia; CRC cis rs10504229 0.775 rs17804840 chr8:58157045 C/T cg22535103 chr8:58192502 C8orf71 -0.7 -8.43 -0.42 1.07e-15 Developmental language disorder (linguistic errors); CRC cis rs12760731 0.623 rs1342849 chr1:178296692 A/G cg00404053 chr1:178313656 RASAL2 0.71 9.05 0.45 1.31e-17 Obesity-related traits; CRC cis rs4664293 0.867 rs2098976 chr2:160593775 T/C cg08347373 chr2:160653686 CD302 -0.47 -7.43 -0.38 9.32e-13 Monocyte percentage of white cells; CRC cis rs514406 0.683 rs6588440 chr1:53209587 C/T cg08859206 chr1:53392774 SCP2 0.42 6.6 0.34 1.69e-10 Monocyte count; CRC cis rs10256972 0.552 rs2949195 chr7:1202705 G/A cg07308232 chr7:1071921 C7orf50 -0.45 -6.17 -0.32 1.97e-9 Longevity;Endometriosis; CRC cis rs9911578 1.000 rs391370 chr17:56675050 A/C cg12560992 chr17:57184187 TRIM37 0.9 16.52 0.67 4.61e-45 Intelligence (multi-trait analysis); CRC cis rs4072705 0.616 rs915033 chr9:127245558 C/G cg13476313 chr9:127244764 NR5A1 0.28 5.71 0.3 2.55e-8 Menarche (age at onset); CRC cis rs7726839 0.540 rs3792720 chr5:643028 T/G cg16447950 chr5:562315 NA -0.74 -9.72 -0.47 8.22e-20 Obesity-related traits; CRC cis rs2439831 0.850 rs61390361 chr15:44159842 C/T cg02155558 chr15:43621948 ADAL;LCMT2 0.69 7.17 0.37 4.89e-12 Lung cancer in ever smokers; CRC cis rs2882667 0.690 rs288032 chr5:138215328 G/A cg09476006 chr5:138032270 NA 0.54 8.92 0.44 3.21e-17 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs832540 0.898 rs252888 chr5:56227326 T/A cg18230493 chr5:56204884 C5orf35 -0.39 -5.81 -0.31 1.46e-8 Coronary artery disease; CRC cis rs2032447 0.714 rs175319 chr6:25956172 A/G cg04800585 chr6:26043546 HIST1H2BB 0.52 7.52 0.38 5.35e-13 Intelligence (multi-trait analysis); CRC cis rs6424115 0.679 rs2076345 chr1:24083494 C/T cg15997130 chr1:24165203 NA -0.62 -7.79 -0.39 8.96e-14 Immature fraction of reticulocytes; CRC cis rs1712517 0.873 rs1712516 chr10:105033628 G/A cg05636881 chr10:105038444 INA 0.5 8.75 0.43 1.1e-16 Migraine; CRC cis rs2836974 0.897 rs2836927 chr21:40543216 T/C cg11644478 chr21:40555479 PSMG1 0.82 12.67 0.57 3.15e-30 Cognitive function; CRC cis rs477895 0.713 rs1059440 chr11:63991801 C/T cg05016508 chr11:63871570 FLRT1;MACROD1 -0.54 -6.98 -0.36 1.64e-11 Mean platelet volume; CRC cis rs9463078 0.746 rs9395095 chr6:45273877 C/A cg25276700 chr6:44698697 NA -0.28 -6.73 -0.35 7.53e-11 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; CRC cis rs4713118 0.826 rs2893929 chr6:27738732 A/T cg15786705 chr6:28176104 NA 0.6 6.74 0.35 7.32e-11 Parkinson's disease; CRC cis rs73198271 0.562 rs3827810 chr8:8659040 T/G cg01851573 chr8:8652454 MFHAS1 0.51 6.18 0.32 1.84e-9 Bone ultrasound measurement (broadband ultrasound attenuation); CRC trans rs12940923 1.000 rs12940923 chr17:56369849 A/T cg16900910 chr15:72789182 ARIH1 0.52 5.97 0.31 6.14e-9 Circulating myeloperoxidase levels (plasma); CRC cis rs72717009 0.825 rs12722986 chr1:161465420 A/G cg15358701 chr1:161410459 NA -0.66 -7.03 -0.36 1.21e-11 Rheumatoid arthritis; CRC cis rs311392 1.000 rs2666870 chr8:55086427 T/C cg20636351 chr8:55087400 NA -0.35 -5.98 -0.31 5.76e-9 Pelvic organ prolapse (moderate/severe); CRC cis rs4588572 0.643 rs1864173 chr5:77691158 C/T cg11446398 chr5:77624930 NA -0.48 -6.61 -0.34 1.51e-10 Triglycerides; CRC trans rs61931739 0.534 rs10844725 chr12:34009504 C/A cg26384229 chr12:38710491 ALG10B 0.54 6.9 0.36 2.76e-11 Morning vs. evening chronotype; CRC cis rs16858210 0.874 rs7618182 chr3:183607003 T/A cg25686905 chr3:183603175 PARL -0.44 -6.23 -0.32 1.44e-9 Menopause (age at onset); CRC cis rs2124969 0.548 rs983916 chr2:161015066 T/G cg03641300 chr2:160917029 PLA2R1 -0.65 -8.34 -0.42 2.08e-15 Waist circumference adjusted for body mass index; CRC cis rs68170813 0.559 rs79978998 chr7:106845482 C/T cg02696742 chr7:106810147 HBP1 -0.61 -6.67 -0.34 1.12e-10 Coronary artery disease; CRC cis rs2067615 0.579 rs1922438 chr12:107085171 C/G cg13491945 chr12:107078410 RFX4 0.35 6.06 0.32 3.67e-9 Heart rate; CRC cis rs6952808 0.760 rs34961072 chr7:1948620 G/C cg02951883 chr7:2050386 MAD1L1 -0.71 -10.84 -0.51 1.29e-23 Bipolar disorder and schizophrenia; CRC cis rs3020333 0.755 rs1293935 chr6:152017958 C/G cg22157087 chr6:152012887 ESR1 0.46 6.96 0.36 1.85e-11 Total body bone mineral density; CRC cis rs2635047 0.638 rs2668784 chr18:44711391 A/G cg19077165 chr18:44547161 KATNAL2 -0.42 -6.62 -0.34 1.48e-10 Educational attainment; CRC cis rs7246760 1.000 rs68176351 chr19:9864222 G/A cg16876255 chr19:9731953 ZNF561 0.68 5.71 0.3 2.5e-8 Pursuit maintenance gain; CRC cis rs2153535 0.580 rs2327057 chr6:8443319 G/A cg07606381 chr6:8435919 SLC35B3 0.67 10.68 0.51 4.61e-23 Motion sickness; CRC cis rs10512697 0.803 rs11745378 chr5:3579723 G/A cg19473799 chr5:3511975 NA -0.72 -5.69 -0.3 2.81e-8 Immune response to smallpox vaccine (IL-6); CRC cis rs6546324 0.625 rs6752799 chr2:67858503 G/A cg15745817 chr2:67799979 NA -0.57 -9.68 -0.47 1.16e-19 Endometriosis; CRC cis rs2016266 0.614 rs7303922 chr12:53654219 A/G cg06632207 chr12:54070931 ATP5G2 0.47 5.98 0.31 5.77e-9 Bone mineral density (spine);Bone mineral density; CRC trans rs8085804 1.000 rs658728 chr18:40222856 C/T cg15579888 chr18:48722878 MEX3C -0.4 -6.01 -0.31 4.8e-9 Cognitive performance; CRC cis rs3889199 1.000 rs12753566 chr1:59654019 T/C cg25881383 chr1:59680599 NA -0.37 -6.02 -0.31 4.68e-9 Pulse pressure; CRC cis rs7584330 0.780 rs12474519 chr2:238377012 G/A cg14458575 chr2:238380390 NA 0.67 12.2 0.56 1.72e-28 Prostate cancer; CRC cis rs7553864 0.518 rs10747341 chr1:87627331 G/A cg17711365 chr1:87617296 LOC339524 0.43 6.69 0.35 9.76e-11 Smoking behavior; CRC cis rs28386778 0.897 rs716880 chr17:61902822 C/G cg06601766 chr17:61851465 DDX42;CCDC47 0.44 5.96 0.31 6.33e-9 Prudent dietary pattern; CRC cis rs4689388 0.853 rs13114527 chr4:6294655 T/G cg00701064 chr4:6280414 WFS1 0.75 13.24 0.59 2.21e-32 Type 2 diabetes and other traits;Type 2 diabetes; CRC cis rs2032447 0.517 rs7767546 chr6:25904067 T/C cg03517284 chr6:25882590 NA -0.76 -11.06 -0.52 2.11e-24 Intelligence (multi-trait analysis); CRC trans rs9467711 0.790 rs34158769 chr6:26336572 G/A cg06606381 chr12:133084897 FBRSL1 -0.97 -6.84 -0.35 3.96e-11 Autism spectrum disorder or schizophrenia; CRC cis rs875971 1.000 rs6460292 chr7:65810075 G/A cg00343986 chr7:65444356 GUSB -0.43 -6.24 -0.33 1.32e-9 Aortic root size; CRC cis rs936229 0.954 rs936230 chr15:75145098 C/T cg10253484 chr15:75165896 SCAMP2 0.42 6.44 0.33 4.34e-10 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); CRC cis rs7412746 0.634 rs12409208 chr1:150860055 A/G cg17724175 chr1:150552817 MCL1 0.47 7.08 0.36 8.64e-12 Melanoma; CRC cis rs8177253 0.665 rs12493887 chr3:133440737 T/C cg24879335 chr3:133465180 TF 0.31 5.68 0.3 3.03e-8 Iron status biomarkers; CRC cis rs7786808 0.608 rs7784758 chr7:158214386 A/G cg09998033 chr7:158218633 PTPRN2 -0.48 -6.74 -0.35 7.21e-11 Obesity-related traits; CRC cis rs2836974 0.965 rs7354783 chr21:40652992 G/A cg17971929 chr21:40555470 PSMG1 0.83 11.88 0.55 2.57e-27 Cognitive function; CRC cis rs6558174 0.965 rs4072394 chr8:22490800 C/T cg03733263 chr8:22462867 KIAA1967 0.48 6.31 0.33 9.17e-10 Breast cancer; CRC cis rs6952808 0.630 rs1860832 chr7:2161849 G/A cg02951883 chr7:2050386 MAD1L1 -0.68 -10.57 -0.5 1.17e-22 Bipolar disorder and schizophrenia; CRC cis rs11711311 1.000 rs12631232 chr3:113497386 C/G cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.54 -7.06 -0.36 1.02e-11 IgG glycosylation; CRC cis rs1997103 0.871 rs9649855 chr7:55410222 T/C cg17469321 chr7:55412551 NA 0.72 11.23 0.53 5.64e-25 QRS interval (sulfonylurea treatment interaction); CRC cis rs9361491 0.510 rs1507151 chr6:79483246 T/C cg09184832 chr6:79620586 NA -0.46 -8.01 -0.4 2e-14 Intelligence (multi-trait analysis); CRC cis rs7618915 0.501 rs2336149 chr3:52692124 G/A cg11645453 chr3:52864694 ITIH4 0.37 6.6 0.34 1.68e-10 Bipolar disorder; CRC cis rs7615952 0.576 rs2276729 chr3:125826214 G/A cg02807482 chr3:125708958 NA -0.43 -5.72 -0.3 2.37e-8 Blood pressure (smoking interaction); CRC cis rs2204008 0.774 rs7959048 chr12:37948276 T/A cg26384229 chr12:38710491 ALG10B 0.67 8.95 0.44 2.61e-17 Bladder cancer; CRC cis rs6752107 0.503 rs13002340 chr2:234234959 G/A cg07618928 chr2:234183455 ATG16L1;SCARNA5 0.52 7.83 0.4 6.7e-14 Crohn's disease;Inflammatory bowel disease; CRC cis rs9807989 0.801 rs6752482 chr2:102967858 T/C cg03938978 chr2:103052716 IL18RAP 0.37 5.97 0.31 6.2e-9 Asthma; CRC cis rs9359856 0.564 rs6914142 chr6:90398903 C/T cg13799429 chr6:90582589 CASP8AP2 -0.74 -8.28 -0.42 3.24e-15 Bipolar disorder; CRC cis rs116979167 0.630 rs56230603 chr7:105165268 A/G cg13798780 chr7:105162888 PUS7 0.69 8.2 0.41 5.36e-15 Bipolar disorder (body mass index interaction); CRC cis rs728616 0.558 rs12414691 chr10:82156982 A/T cg05935833 chr10:81318306 SFTPA2 -0.58 -6.97 -0.36 1.74e-11 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs889398 0.741 rs6499270 chr16:69917740 A/G cg00738113 chr16:70207722 CLEC18C 0.34 5.79 0.3 1.63e-8 Body mass index; CRC cis rs736408 0.677 rs2286798 chr3:52821177 G/T cg18099408 chr3:52552593 STAB1 0.38 6.18 0.32 1.9e-9 Bipolar disorder; CRC cis rs7727544 0.507 rs11741341 chr5:131570218 A/G cg20512303 chr5:131592959 PDLIM4 0.38 6.97 0.36 1.75e-11 Blood metabolite levels; CRC cis rs62103177 1.000 rs62103177 chr18:77624479 G/A cg12964065 chr18:77638022 KCNG2 0.66 6.69 0.35 9.58e-11 Opioid sensitivity; CRC cis rs9287719 0.967 rs2010080 chr2:10736552 A/T cg00105475 chr2:10696890 NA 0.45 7.3 0.37 2.19e-12 Prostate cancer; CRC cis rs1218582 0.741 rs2335407 chr1:154843347 A/G cg09359103 chr1:154839909 KCNN3 0.74 13.51 0.6 2.16e-33 Prostate cancer; CRC cis rs1552244 0.554 rs34883592 chr3:10046165 C/T cg16606324 chr3:10149918 C3orf24 0.48 7.09 0.36 8.29e-12 Alzheimer's disease; CRC cis rs720844 0.688 rs13010027 chr2:149326704 G/A cg09247360 chr2:149335327 NA -0.55 -5.98 -0.31 5.75e-9 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs3008870 1.000 rs2755246 chr1:67488984 A/G cg08660285 chr1:67390436 MIER1;WDR78 0.97 13.83 0.61 1.26e-34 Lymphocyte percentage of white cells; CRC cis rs4629710 0.568 rs9492880 chr6:131565962 G/T cg12606694 chr6:131520996 AKAP7 0.54 8.09 0.41 1.13e-14 Multiple myeloma (IgH translocation); CRC cis rs881375 0.678 rs10760128 chr9:123696325 C/T cg09586646 chr9:123605570 PSMD5;LOC253039 0.45 6.63 0.34 1.41e-10 Rheumatoid arthritis; CRC cis rs644799 0.710 rs11021311 chr11:95505227 G/A cg03916912 chr11:95522834 CEP57;FAM76B 0.85 15.48 0.65 5.58e-41 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs7772486 0.686 rs1292334 chr6:145968288 A/G cg13319975 chr6:146136371 FBXO30 -0.44 -6.54 -0.34 2.37e-10 Lobe attachment (rater-scored or self-reported); CRC trans rs3942852 0.806 rs4752808 chr11:48141252 G/A cg03929089 chr4:120376271 NA -0.55 -6.97 -0.36 1.76e-11 Acute lymphoblastic leukemia (childhood); CRC cis rs9291683 0.669 rs887733 chr4:10183108 T/C cg00071950 chr4:10020882 SLC2A9 -0.42 -6.85 -0.35 3.72e-11 Bone mineral density; CRC cis rs2290416 0.786 rs60401352 chr8:144673097 G/A cg17524265 chr8:144659883 NAPRT1 0.65 5.63 0.3 3.85e-8 Attention deficit hyperactivity disorder; CRC cis rs2573652 1.000 rs2581341 chr15:100514494 T/C cg00587665 chr15:100533223 ADAMTS17 -0.36 -6.19 -0.32 1.77e-9 Height; CRC trans rs1578862 0.872 rs1771918 chr1:247433035 A/G cg06850283 chr5:44389769 FGF10 -0.26 -6.36 -0.33 6.76e-10 Monocyte percentage of white cells; CRC trans rs1455244 0.700 rs7229302 chr18:11508904 G/T cg10082270 chr16:87425748 FBXO31;MAP1LC3B 0.39 6.02 0.31 4.56e-9 Schizophrenia; CRC cis rs3733585 0.674 rs7375643 chr4:9955239 A/G cg11266682 chr4:10021025 SLC2A9 -0.51 -10.54 -0.5 1.45e-22 Cleft plate (environmental tobacco smoke interaction); CRC cis rs7493 0.901 rs2237586 chr7:95051052 G/T cg19678392 chr7:94953810 PON1 -0.6 -7.35 -0.38 1.54e-12 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs9296092 0.538 rs62405948 chr6:33522753 A/C cg13560919 chr6:33536144 NA -0.43 -6.17 -0.32 2.04e-9 Age at smoking initiation in chronic obstructive pulmonary disease; CRC cis rs8072100 0.512 rs9674670 chr17:45386157 G/A cg08085267 chr17:45401833 C17orf57 -0.76 -13.33 -0.59 1.07e-32 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC trans rs9929218 0.529 rs11640736 chr16:68738324 G/T cg04657470 chr2:198365150 HSPE1;HSPD1 0.98 18.24 0.71 7.34e-52 Colorectal cancer; CRC cis rs344364 0.511 rs2982452 chr16:1949511 G/A cg00046913 chr16:1877150 HAGH;FAHD1 -0.58 -6.06 -0.32 3.66e-9 Glomerular filtration rate in chronic kidney disease; CRC cis rs4243830 0.850 rs12030607 chr1:6601007 T/A cg05709478 chr1:6581295 PLEKHG5 0.65 7.63 0.39 2.57e-13 Body mass index; CRC cis rs9372498 0.536 rs2356501 chr6:118942371 C/A cg18833306 chr6:118973337 C6orf204 0.45 5.81 0.3 1.49e-8 Diastolic blood pressure; CRC cis rs4888262 0.545 rs4072450 chr16:74666634 G/C cg01733217 chr16:74700730 RFWD3 0.82 12.58 0.57 6.93e-30 Testicular germ cell tumor; CRC cis rs8105895 0.877 rs8100768 chr19:22270468 T/C cg02657401 chr19:22469223 NA -0.34 -5.63 -0.3 3.89e-8 Body mass index (change over time); CRC cis rs12826942 0.605 rs17801484 chr12:42483931 T/C cg11827402 chr12:42719852 PPHLN1;ZCRB1 0.58 6.2 0.32 1.72e-9 Coronary artery disease; CRC cis rs79349575 0.783 rs62078372 chr17:47028989 T/C cg22482690 chr17:47019901 SNF8 0.5 8.26 0.41 3.58e-15 Type 2 diabetes; CRC cis rs6502050 0.761 rs11653003 chr17:80058795 G/T cg02741985 chr17:80059408 CCDC57 -0.46 -7.37 -0.38 1.38e-12 Life satisfaction; CRC cis rs12545109 0.800 rs1837620 chr8:57399473 C/A cg09654669 chr8:57350985 NA -0.38 -5.65 -0.3 3.57e-8 Obesity-related traits; CRC cis rs7107174 0.901 rs10899496 chr11:78123831 A/G cg12700464 chr11:78128424 GAB2 -0.49 -5.91 -0.31 8.33e-9 Testicular germ cell tumor; CRC cis rs3736485 0.578 rs11638106 chr15:51969295 C/T cg08986416 chr15:51914746 DMXL2 -0.39 -5.66 -0.3 3.31e-8 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs2836974 0.526 rs1888488 chr21:40686521 C/T cg17971929 chr21:40555470 PSMG1 -0.61 -8.83 -0.44 6.42e-17 Cognitive function; CRC cis rs13191362 1.000 rs13220181 chr6:163004401 T/A cg21926612 chr6:163149169 PACRG;PARK2 0.76 11.15 0.52 1.03e-24 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs317689 0.581 rs160829 chr12:69769538 G/C cg20891283 chr12:69753455 YEATS4 0.71 10.05 0.48 6.63e-21 Response to diuretic therapy; CRC cis rs35883536 0.647 rs10875317 chr1:101045438 G/T cg06223162 chr1:101003688 GPR88 -0.35 -6.56 -0.34 2.09e-10 Monocyte count; CRC cis rs9486719 0.947 rs11757102 chr6:96885073 G/A cg06623918 chr6:96969491 KIAA0776 -0.81 -9.51 -0.46 4.17e-19 Migraine;Coronary artery disease; CRC cis rs55883249 1.000 rs55883249 chr2:9741535 C/A cg23886495 chr2:9695866 ADAM17 0.52 5.89 0.31 9.33e-9 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; CRC cis rs11098499 0.909 rs28884220 chr4:120307211 A/G cg24375607 chr4:120327624 NA 0.51 7.88 0.4 4.76e-14 Corneal astigmatism; CRC cis rs7772486 0.754 rs697055 chr6:146003790 C/G cg23711669 chr6:146136114 FBXO30 0.72 11.6 0.54 2.62e-26 Lobe attachment (rater-scored or self-reported); CRC cis rs7208859 0.673 rs11080135 chr17:29176481 A/G cg13385521 chr17:29058706 SUZ12P 0.69 8.02 0.4 1.81e-14 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs10540 0.908 rs1044707 chr11:491334 G/T cg03352830 chr11:487213 PTDSS2 -0.64 -7.46 -0.38 8.01e-13 Body mass index; CRC cis rs4820539 1.000 rs4820539 chr22:23477970 C/T cg14186256 chr22:23484241 RTDR1 -0.84 -16.2 -0.67 8.18e-44 Bone mineral density; CRC cis rs2573652 0.722 rs11630930 chr15:100544145 G/T cg00587665 chr15:100533223 ADAMTS17 -0.37 -6.58 -0.34 1.9e-10 Height; CRC cis rs875971 0.862 rs778736 chr7:65813848 C/T cg18876405 chr7:65276391 NA 0.54 8.67 0.43 1.96e-16 Aortic root size; CRC cis rs853679 0.517 rs6941992 chr6:28106141 T/C cg18032046 chr6:28092343 ZSCAN16 -0.52 -6.08 -0.32 3.3e-9 Depression; CRC cis rs17818399 0.547 rs4953400 chr2:46777208 T/A cg06386533 chr2:46925753 SOCS5 0.45 5.67 0.3 3.15e-8 Height; CRC cis rs10782582 0.609 rs11584577 chr1:76242378 A/G cg10523679 chr1:76189770 ACADM -0.39 -5.61 -0.3 4.39e-8 Daytime sleep phenotypes; CRC cis rs853679 0.517 rs4713148 chr6:28115921 G/A cg12963246 chr6:28129442 ZNF389 0.49 5.7 0.3 2.71e-8 Depression; CRC trans rs61931739 0.534 rs4931775 chr12:34050729 G/A cg26384229 chr12:38710491 ALG10B 0.53 6.77 0.35 5.85e-11 Morning vs. evening chronotype; CRC cis rs4692589 0.965 rs6847470 chr4:170954468 T/C cg19918862 chr4:170955249 NA 0.36 5.71 0.3 2.5e-8 Anxiety disorder; CRC cis rs9322193 0.923 rs12526675 chr6:150050676 A/C cg13206674 chr6:150067644 NUP43 -0.63 -9.01 -0.44 1.73e-17 Lung cancer; CRC cis rs870825 0.616 rs7668009 chr4:185641998 A/C cg04058563 chr4:185651563 MLF1IP 0.7 9.05 0.45 1.29e-17 Blood protein levels; CRC cis rs12580194 0.593 rs7487895 chr12:55796720 T/C cg19537932 chr12:55886519 OR6C68 -0.73 -9.28 -0.46 2.34e-18 Cancer; CRC cis rs11608355 0.515 rs7976796 chr12:109928013 C/T cg05360138 chr12:110035743 NA 0.78 8.76 0.43 1.07e-16 Neuroticism; CRC cis rs7618915 0.508 rs13065851 chr3:52644836 T/A cg10802521 chr3:52805072 NEK4 -0.57 -8.71 -0.43 1.52e-16 Bipolar disorder; CRC cis rs832540 0.656 rs832573 chr5:56159578 T/C cg24531977 chr5:56204891 C5orf35 -0.5 -7.37 -0.38 1.41e-12 Coronary artery disease; CRC cis rs2878628 0.650 rs56098033 chr3:52758571 T/A cg18404041 chr3:52824283 ITIH1 -0.4 -8.34 -0.42 2.1e-15 Intelligence (multi-trait analysis); CRC cis rs709400 0.663 rs62007684 chr14:103894223 T/C cg12935359 chr14:103987150 CKB -0.52 -8.06 -0.41 1.43e-14 Body mass index; CRC cis rs806215 0.950 rs989099 chr7:127220827 A/G cg25922125 chr7:127225783 GCC1 -0.65 -7.03 -0.36 1.23e-11 Type 2 diabetes; CRC cis rs10504229 0.683 rs7459958 chr8:58111905 G/T cg24829409 chr8:58192753 C8orf71 -0.55 -7.9 -0.4 4.11e-14 Developmental language disorder (linguistic errors); CRC cis rs2836950 0.565 rs2836931 chr21:40546569 T/G cg11890956 chr21:40555474 PSMG1 -0.69 -10.48 -0.5 2.33e-22 Menarche (age at onset); CRC cis rs9443645 0.527 rs10943600 chr6:79611505 G/A cg05283184 chr6:79620031 NA -0.45 -6.57 -0.34 1.99e-10 Intelligence (multi-trait analysis); CRC cis rs798554 0.797 rs1182184 chr7:2872446 G/A cg13628971 chr7:2884303 GNA12 0.54 7.29 0.37 2.27e-12 Height; CRC cis rs56104184 0.775 rs117016425 chr19:49400216 C/T cg21252483 chr19:49399788 TULP2 -0.43 -6.62 -0.34 1.49e-10 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; CRC cis rs4731207 0.662 rs7782031 chr7:124505784 C/A cg23710748 chr7:124431027 NA -0.38 -6.08 -0.32 3.42e-9 Cutaneous malignant melanoma; CRC cis rs17767392 0.595 rs60536344 chr14:71654400 G/A cg13720639 chr14:72061746 SIPA1L1 -0.46 -5.86 -0.31 1.15e-8 Mitral valve prolapse; CRC cis rs9488822 0.676 rs873879 chr6:116391259 A/G cg26893134 chr6:116381904 FRK 0.28 7.97 0.4 2.67e-14 Cholesterol, total;LDL cholesterol; CRC cis rs13108904 0.901 rs13124847 chr4:1278206 A/G cg02018176 chr4:1364513 KIAA1530 0.48 7.93 0.4 3.43e-14 Obesity-related traits; CRC cis rs763121 0.853 rs5750669 chr22:39080638 T/A cg06544989 chr22:39130855 UNC84B 0.46 7.01 0.36 1.37e-11 Menopause (age at onset); CRC cis rs6952808 1.000 rs12699404 chr7:1894022 A/T cg02951883 chr7:2050386 MAD1L1 -0.75 -11.66 -0.54 1.51e-26 Bipolar disorder and schizophrenia; CRC cis rs3785574 0.962 rs2665799 chr17:61919723 A/G cg23090583 chr17:61904693 PSMC5;FTSJ3 0.65 9.19 0.45 4.59e-18 Height; CRC cis rs4566357 0.521 rs78411533 chr2:227910807 G/A cg11843606 chr2:227700838 RHBDD1 -0.44 -6.85 -0.35 3.54e-11 Coronary artery disease; CRC cis rs6834538 1.000 rs6823117 chr4:113447354 T/C cg10021238 chr4:113569128 MIR367;LARP7 -0.43 -6.12 -0.32 2.62e-9 Free thyroxine concentration; CRC cis rs8072100 0.666 rs9913014 chr17:45460189 C/T cg08085267 chr17:45401833 C17orf57 -0.57 -8.52 -0.42 6e-16 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC trans rs1814175 0.817 rs10839397 chr11:49857074 C/T cg15704280 chr7:45808275 SEPT13 -0.96 -18.34 -0.71 3.01e-52 Height; CRC cis rs9914988 0.943 rs9890155 chr17:27125467 A/G cg12682573 chr17:27188876 MIR451;MIR144 0.58 7.99 0.4 2.37e-14 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC trans rs7615952 0.546 rs2979307 chr3:125309574 C/T cg07211511 chr3:129823064 LOC729375 0.52 6.23 0.32 1.43e-9 Blood pressure (smoking interaction); CRC cis rs3617 0.625 rs2240915 chr3:52859526 T/A cg15147215 chr3:52552868 STAB1 -0.54 -9.36 -0.46 1.28e-18 Red blood cell count;Autism spectrum disorder or schizophrenia; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg03642513 chr4:71859104 DCK 0.48 6.99 0.36 1.5e-11 Response to antipsychotic treatment; CRC trans rs1455244 0.700 rs7229302 chr18:11508904 G/T cg20022578 chr7:73081950 VPS37D 0.39 5.97 0.31 6.29e-9 Schizophrenia; CRC cis rs142958719 1 rs142958719 chr5:131232959 G/A cg06307176 chr5:131281290 NA -0.43 -6.17 -0.32 2.02e-9 Alzheimer's disease in APOE e4- carriers; CRC cis rs7552404 0.731 rs1770885 chr1:76402212 C/T cg03433033 chr1:76189801 ACADM -0.58 -7.18 -0.37 4.7e-12 Blood metabolite levels;Acylcarnitine levels; CRC trans rs113835537 0.627 rs4630309 chr11:66333072 A/C cg02323633 chr5:73937762 ENC1 0.59 6.33 0.33 8.23e-10 Airway imaging phenotypes; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg25504222 chr19:4639508 TNFAIP8L1 0.42 6.43 0.33 4.62e-10 Intelligence (multi-trait analysis); CRC cis rs344364 0.511 rs337286 chr16:1965719 C/T cg14074117 chr16:1909714 C16orf73 0.45 6.16 0.32 2.12e-9 Glomerular filtration rate in chronic kidney disease; CRC cis rs4332037 0.539 rs57148375 chr7:2025001 G/C cg23378565 chr7:2036160 MAD1L1 -0.48 -6.88 -0.35 3.08e-11 Bipolar disorder; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg11759937 chr19:47729458 BBC3 0.39 6.33 0.33 8.08e-10 Liver disease severity in Alagille syndrome; CRC cis rs4319547 0.619 rs10744208 chr12:122931559 C/A cg05707623 chr12:122985044 ZCCHC8 -0.75 -9.27 -0.46 2.46e-18 Body mass index; CRC cis rs1862618 0.853 rs832582 chr5:56177743 G/A cg12311346 chr5:56204834 C5orf35 -0.79 -10.04 -0.48 7.48e-21 Initial pursuit acceleration; CRC cis rs9463078 0.547 rs9472362 chr6:44751285 C/A cg25276700 chr6:44698697 NA 0.3 7.62 0.39 2.74e-13 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; CRC cis rs7208859 0.623 rs8081299 chr17:29104296 G/A cg01831904 chr17:28903510 LRRC37B2 -0.63 -6.43 -0.33 4.56e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs9311474 0.508 rs12629701 chr3:52619836 T/C cg05573699 chr3:52720067 GNL3;PBRM1 -0.44 -6.43 -0.33 4.62e-10 Electroencephalogram traits; CRC trans rs116095464 0.558 rs6878061 chr5:223072 A/G cg00938859 chr5:1591904 SDHAP3 0.68 7.39 0.38 1.24e-12 Breast cancer; CRC cis rs853679 0.517 rs9393895 chr6:28127621 T/C cg15845792 chr6:28175446 NA 1.01 13.44 0.6 4.09e-33 Depression; CRC cis rs1950626 0.833 rs35436326 chr14:101396148 G/A cg02351406 chr14:101447389 SNORD114-20;SNORD114-21 0.95 15.88 0.66 1.43e-42 Pelvic organ prolapse (moderate/severe); CRC trans rs208520 0.565 rs1385222 chr6:66753013 C/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 1.1 20.81 0.75 5.86e-62 Exhaled nitric oxide output; CRC cis rs6662572 0.737 rs72692603 chr1:46378838 T/C cg03123370 chr1:45965343 CCDC163P;MMACHC 0.45 5.74 0.3 2.17e-8 Blood protein levels; CRC trans rs10242455 0.702 rs112475236 chr7:99044679 A/G cg09045935 chr12:6379348 NA 1.03 8.86 0.44 5.29e-17 Blood metabolite levels; CRC trans rs2243480 1.000 rs316313 chr7:65593548 G/A cg10756647 chr7:56101905 PSPH 0.74 7.74 0.39 1.23e-13 Diabetic kidney disease; CRC cis rs9914988 0.943 rs11656256 chr17:27153553 G/A cg20469991 chr17:27169893 C17orf63 -0.59 -7.19 -0.37 4.48e-12 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs2032447 0.933 rs4401650 chr6:26035208 G/A cg18357526 chr6:26021779 HIST1H4A 0.76 11.6 0.54 2.66e-26 Intelligence (multi-trait analysis); CRC trans rs17086954 0.548 rs62436482 chr6:156321151 C/T cg07027430 chr16:7354685 A2BP1 -0.2 -5.98 -0.31 5.87e-9 Early childhood aggressive behavior; CRC cis rs1559088 0.847 rs8110181 chr19:33605939 G/A cg27124370 chr19:33622961 WDR88 0.44 6.07 0.32 3.48e-9 Bone ultrasound measurement (broadband ultrasound attenuation); CRC cis rs35306767 0.501 rs4880763 chr10:1147045 G/A cg20503657 chr10:835505 NA 0.73 8.36 0.42 1.85e-15 Eosinophil percentage of granulocytes; CRC cis rs57994353 0.861 rs34302850 chr9:139327064 A/G cg13856295 chr9:139396418 NOTCH1 -0.42 -5.86 -0.31 1.12e-8 Eosinophil counts;Cutaneous squamous cell carcinoma; CRC cis rs6761276 0.866 rs12469822 chr2:113830563 C/T cg24553058 chr2:113831203 IL1F10 0.41 6.52 0.34 2.6200000000000003e-10 Protein quantitative trait loci; CRC cis rs2370759 1.000 rs11599522 chr10:32568434 G/C cg01819863 chr10:32635814 EPC1 1.09 12.92 0.58 3.64e-31 Sexual dysfunction (female); CRC cis rs10751667 0.666 rs11246357 chr11:963980 A/C cg01483505 chr11:975446 AP2A2 0.44 7.33 0.37 1.81e-12 Alzheimer's disease (late onset); CRC cis rs79387448 0.655 rs11891827 chr2:102951182 A/G cg09003973 chr2:102972529 NA 0.96 10.0 0.48 9.65e-21 Gut microbiota (bacterial taxa); CRC trans rs10411161 0.810 rs57171871 chr19:52385332 T/C cg22319618 chr22:45562946 NUP50 -0.69 -6.0 -0.31 5.21e-9 Breast cancer; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg22674793 chr4:71570323 RUFY3 0.39 6.33 0.33 7.92e-10 Liver disease severity in Alagille syndrome; CRC cis rs7208859 0.673 rs9891413 chr17:29208209 G/C cg14008862 chr17:28927542 LRRC37B2 0.55 5.74 0.3 2.12e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs6988985 0.667 rs7818953 chr8:143959289 T/C cg10324643 chr8:143916377 GML 0.39 6.39 0.33 5.63e-10 Plasma androstenedione levels in resected early stage-receptor positive breast cancer; CRC cis rs9457247 0.508 rs9457268 chr6:167503639 A/T cg07513332 chr6:167530253 CCR6 0.36 6.34 0.33 7.37e-10 Crohn's disease; CRC cis rs4862750 0.914 rs1863405 chr4:187874528 G/T cg11301795 chr4:187892539 NA 0.84 18.93 0.72 1.37e-54 Lobe attachment (rater-scored or self-reported); CRC trans rs34816374 1 rs34816374 chr6:26949672 A/G cg06606381 chr12:133084897 FBRSL1 -0.98 -6.94 -0.36 2.1e-11 Lung cancer in ever smokers; CRC cis rs425277 0.606 rs2503705 chr1:2076741 A/G cg12639453 chr1:2035780 PRKCZ 0.35 6.82 0.35 4.37e-11 Height; CRC cis rs4820294 0.770 rs7285699 chr22:38066556 A/C cg21798802 chr22:38057573 PDXP 0.37 6.11 0.32 2.75e-9 Fat distribution (HIV); CRC cis rs28386778 0.897 rs2727328 chr17:61923564 G/A cg06873352 chr17:61820015 STRADA 0.76 14.24 0.62 3.62e-36 Prudent dietary pattern; CRC cis rs3858526 0.834 rs10839166 chr11:6002464 T/C cg02574844 chr11:5959923 NA -0.42 -5.73 -0.3 2.28e-8 DNA methylation (variation); CRC cis rs7523050 0.643 rs12725689 chr1:109405151 T/C cg08274380 chr1:109419600 GPSM2 0.93 7.09 0.36 8.34e-12 Fat distribution (HIV); CRC cis rs11148252 0.904 rs9536079 chr13:53030565 G/A cg02158880 chr13:53174818 NA 0.48 7.24 0.37 3.16e-12 Lewy body disease; CRC cis rs72781680 0.821 rs12616257 chr2:24135034 A/G cg08917208 chr2:24149416 ATAD2B 0.55 6.71 0.35 8.52e-11 Lymphocyte counts; CRC cis rs6502050 0.698 rs67143649 chr17:80117772 C/G cg09264619 chr17:80180166 NA -0.35 -5.93 -0.31 7.76e-9 Life satisfaction; CRC cis rs801193 0.935 rs2659916 chr7:66151352 C/G cg00343986 chr7:65444356 GUSB 0.49 7.25 0.37 3.04e-12 Aortic root size; CRC cis rs10504229 1.000 rs58947041 chr8:58188934 G/A cg01721255 chr8:58191610 C8orf71 0.48 6.06 0.32 3.81e-9 Developmental language disorder (linguistic errors); CRC trans rs2303319 0.504 rs72877343 chr2:162607487 A/C cg14875682 chr5:52083620 ITGA1;PELO -0.73 -6.16 -0.32 2.11e-9 Cognitive function; CRC cis rs9341808 0.727 rs4706834 chr6:81012605 G/T cg08355045 chr6:80787529 NA 0.35 5.7 0.3 2.63e-8 Sitting height ratio; CRC cis rs7635838 0.684 rs384989 chr3:11320120 C/T cg00170343 chr3:11313890 ATG7 0.51 7.82 0.4 7.42e-14 HDL cholesterol; CRC cis rs79976124 0.837 rs10944858 chr6:66646039 G/A cg07460842 chr6:66804631 NA 0.75 9.38 0.46 1.07e-18 Type 2 diabetes; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg10457504 chr17:19281708 MAPK7 0.49 6.59 0.34 1.72e-10 Thyroid stimulating hormone; CRC cis rs950776 0.518 rs12916483 chr15:78832397 G/A cg06917634 chr15:78832804 PSMA4 0.68 10.68 0.51 4.64e-23 Sudden cardiac arrest; CRC cis rs6547741 1.000 rs1528404 chr2:27846603 C/T cg27432699 chr2:27873401 GPN1 -0.75 -13.32 -0.59 1.14e-32 Oral cavity cancer; CRC cis rs548181 0.736 rs1941558 chr11:125425606 C/T cg03464685 chr11:125439445 EI24 1.2 12.89 0.58 4.87e-31 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC trans rs12195424 0.730 rs9475698 chr6:56298924 A/G cg00011284 chr16:53469344 RBL2 0.51 6.09 0.32 3.1e-9 Cerebrospinal fluid clusterin levels; CRC cis rs9837602 0.688 rs793488 chr3:99495567 T/C cg07805332 chr3:99536008 MIR548G;C3orf26 0.48 5.86 0.31 1.15e-8 Breast cancer; CRC cis rs155076 0.625 rs4769159 chr13:21881978 A/C cg25811766 chr13:21894605 NA 0.57 6.77 0.35 5.88e-11 White matter hyperintensity burden; CRC cis rs7811142 0.830 rs11765869 chr7:99964789 T/G cg00814883 chr7:100076585 TSC22D4 -0.72 -8.79 -0.44 8.62e-17 Platelet count; CRC cis rs12476592 0.571 rs262520 chr2:63892432 T/C cg10828910 chr2:63850056 LOC388955 0.51 6.44 0.33 4.22e-10 Childhood ear infection; CRC cis rs853679 0.517 rs9468297 chr6:28118874 G/T cg06470822 chr6:28175283 NA 1.03 13.59 0.6 1.04e-33 Depression; CRC cis rs6860806 0.507 rs635620 chr5:131720263 A/G cg07395648 chr5:131743802 NA 0.41 5.69 0.3 2.8e-8 Breast cancer; CRC cis rs9911578 1.000 rs7342903 chr17:56914588 C/G cg12560992 chr17:57184187 TRIM37 0.92 16.91 0.68 1.29e-46 Intelligence (multi-trait analysis); CRC cis rs2197308 0.610 rs10880837 chr12:37864924 C/T cg13010199 chr12:38710504 ALG10B 0.44 5.64 0.3 3.63e-8 Morning vs. evening chronotype; CRC cis rs875971 1.000 rs4718343 chr7:65874288 T/G cg11764359 chr7:65958608 NA 0.61 9.95 0.48 1.41e-20 Aortic root size; CRC cis rs9648716 1.000 rs56797136 chr7:140573485 C/T cg10747023 chr7:140774559 NA 0.45 5.82 0.31 1.36e-8 Type 2 diabetes; CRC cis rs7619833 0.620 rs11129270 chr3:27257943 A/G cg02860705 chr3:27208620 NA 0.37 5.86 0.31 1.15e-8 Breast cancer; CRC cis rs1218582 0.772 rs4240874 chr1:154885779 C/T cg06221963 chr1:154839813 KCNN3 -0.77 -15.47 -0.65 5.8e-41 Prostate cancer; CRC cis rs8060686 0.641 rs113502835 chr16:68238965 A/T cg08314208 chr16:67682810 RLTPR -0.54 -5.94 -0.31 7.18e-9 HDL cholesterol;Metabolic syndrome; CRC cis rs8072100 0.713 rs57427906 chr17:45494014 G/A cg08085267 chr17:45401833 C17orf57 -0.58 -8.74 -0.43 1.22e-16 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs2795502 0.938 rs3121324 chr10:43379515 C/T cg20628663 chr10:43360327 NA 0.56 9.19 0.45 4.6e-18 Blood protein levels; CRC cis rs72615157 0.612 rs7786505 chr7:99817585 G/T cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.46 5.83 0.31 1.32e-8 Lung function (FEV1/FVC); CRC cis rs755249 0.567 rs61779308 chr1:39938257 C/T cg18385671 chr1:39797026 MACF1 -0.41 -5.68 -0.3 2.93e-8 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs1448094 0.512 rs7303330 chr12:86255123 G/A cg25456477 chr12:86230367 RASSF9 0.33 5.78 0.3 1.69e-8 Major depressive disorder; CRC cis rs7727544 0.636 rs2631365 chr5:131705949 T/C cg21138405 chr5:131827807 IRF1 0.32 5.69 0.3 2.75e-8 Blood metabolite levels; CRC cis rs427394 0.659 rs175594 chr5:6729885 T/G cg15145174 chr5:6755386 POLS -0.46 -6.8 -0.35 5e-11 Menopause (age at onset); CRC cis rs6662572 0.737 rs6673894 chr1:46301182 G/A cg08644498 chr1:46502608 NA -0.44 -6.97 -0.36 1.74e-11 Blood protein levels; CRC cis rs60871478 0.838 rs12530859 chr7:835034 G/A cg13798912 chr7:905769 UNC84A -0.53 -5.88 -0.31 1.03e-8 Cerebrospinal P-tau181p levels; CRC cis rs2456568 0.741 rs2102332 chr11:93635281 G/T cg26875233 chr11:93583750 C11orf90 -0.32 -6.27 -0.33 1.11e-9 Response to serotonin reuptake inhibitors in major depressive disorder; CRC cis rs9649213 0.593 rs7789380 chr7:97956180 G/A cg08684580 chr7:98029266 BAIAP2L1 -0.31 -5.62 -0.3 4.05e-8 Prostate cancer (SNP x SNP interaction); CRC cis rs12541335 0.639 rs13257108 chr8:22165043 T/C cg18135555 chr8:22132992 PIWIL2 0.4 7.95 0.4 3.07e-14 Hypertriglyceridemia; CRC cis rs7312774 0.618 rs4964503 chr12:107335937 C/G cg16260113 chr12:107380972 MTERFD3 -0.79 -7.72 -0.39 1.41e-13 Severe influenza A (H1N1) infection; CRC cis rs910316 1.000 rs3742778 chr14:75538217 A/C cg03030879 chr14:75389066 RPS6KL1 0.47 7.46 0.38 7.56e-13 Height; CRC cis rs883565 0.771 rs3736573 chr3:39129742 A/C cg01426195 chr3:39028469 NA -0.54 -8.3 -0.42 2.82e-15 Handedness; CRC cis rs769267 0.965 rs2269873 chr19:19392401 T/C cg02546618 chr19:19431379 KIAA0892;SF4 0.46 6.3 0.33 9.51e-10 Tonsillectomy; CRC cis rs77106637 0.932 rs7109082 chr11:72707441 A/C cg03713592 chr11:72463424 ARAP1 0.76 7.42 0.38 1.04e-12 Type 2 diabetes; CRC cis rs9318086 0.712 rs9510917 chr13:24442846 C/T cg25267304 chr13:24462978 PCOTH;MIPEP 0.61 9.72 0.47 8.54e-20 Myopia (pathological); CRC cis rs8077889 1.000 rs17675122 chr17:41886190 A/G cg26893861 chr17:41843967 DUSP3 0.98 12.79 0.58 1.12e-30 Triglycerides; CRC cis rs73206853 0.764 rs6606685 chr12:110881986 C/G cg12870014 chr12:110450643 ANKRD13A 0.7 8.9 0.44 3.95e-17 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC cis rs6460942 1.000 rs79659770 chr7:12326371 T/C cg06484146 chr7:12443880 VWDE -0.77 -7.55 -0.38 4.39e-13 Coronary artery disease; CRC cis rs12474201 0.572 rs7596521 chr2:46918665 A/G cg06386533 chr2:46925753 SOCS5 0.55 7.47 0.38 7.21e-13 Height; CRC cis rs72634258 0.842 rs6668846 chr1:8152102 C/G cg26816564 chr1:7831052 VAMP3 -0.57 -6.59 -0.34 1.79e-10 Inflammatory bowel disease; CRC cis rs2361718 0.500 rs4889970 chr17:78096086 C/T cg20811857 chr17:78079795 GAA 0.53 7.21 0.37 3.81e-12 Yeast infection; CRC cis rs7945705 0.869 rs2742471 chr11:9003953 C/T cg14711859 chr11:8959438 ASCL3 0.42 7.03 0.36 1.23e-11 Hemoglobin concentration; CRC cis rs9372498 0.536 rs62421539 chr6:118730559 C/A cg10217327 chr6:118973057 C6orf204 0.5 5.69 0.3 2.82e-8 Diastolic blood pressure; CRC cis rs2836974 0.666 rs35182074 chr21:40685284 A/C cg22974920 chr21:40686053 BRWD1 -0.45 -6.0 -0.31 5.12e-9 Cognitive function; CRC cis rs933688 1.000 rs10058025 chr5:90689052 A/G cg02339078 chr5:90679543 LOC100129716;ARRDC3 0.92 13.87 0.61 9.28e-35 Smoking behavior; CRC cis rs10540 1.000 rs12786555 chr11:506229 C/T cg03934478 chr11:495069 RNH1 0.69 7.77 0.39 9.92e-14 Body mass index; CRC cis rs12753569 0.934 rs10430051 chr1:76491628 T/G cg00791851 chr1:76518896 NA -0.4 -7.13 -0.37 6.38e-12 Personality dimensions; CRC cis rs1538970 0.884 rs61788261 chr1:45899114 G/A cg05343316 chr1:45956843 TESK2 0.74 10.05 0.48 6.51e-21 Platelet count; CRC cis rs9814567 1.000 rs934093 chr3:134195885 A/G cg06541857 chr3:134203789 ANAPC13;CEP63 -0.42 -6.34 -0.33 7.48e-10 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs7666738 0.830 rs13134216 chr4:98919765 C/T cg17366294 chr4:99064904 C4orf37 0.43 7.24 0.37 3.2e-12 Colonoscopy-negative controls vs population controls; CRC cis rs2479724 0.840 rs6925777 chr6:41750822 C/T cg17623882 chr6:41773611 USP49 0.57 9.7 0.47 9.56e-20 Menarche (age at onset); CRC cis rs10504229 0.728 rs17804624 chr8:58154216 T/C cg24829409 chr8:58192753 C8orf71 -0.58 -7.96 -0.4 2.86e-14 Developmental language disorder (linguistic errors); CRC cis rs12348691 0.503 rs6478423 chr9:100592030 C/T cg13688889 chr9:100608707 NA -0.48 -6.18 -0.32 1.85e-9 Alopecia areata; CRC cis rs6088590 1.000 rs2295353 chr20:33356511 C/T cg24642439 chr20:33292090 TP53INP2 0.61 11.01 0.52 3.4e-24 Coronary artery disease; CRC trans rs637571 0.584 rs659824 chr11:65636509 A/G cg17712092 chr4:129076599 LARP1B -0.61 -9.7 -0.47 1.02e-19 Eosinophil percentage of white cells; CRC trans rs11252926 0.966 rs61831030 chr10:578869 C/T cg00953403 chr17:74099816 EXOC7 -0.46 -6.22 -0.32 1.54e-9 Psychosis in Alzheimer's disease; CRC trans rs1488564 1.000 rs1488564 chr3:173453868 A/G cg13809815 chr14:24912071 SDR39U1 0.43 6.53 0.34 2.43e-10 Age-related hearing impairment (SNP x SNP interaction); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg21613324 chr5:175875188 FAF2 0.49 6.96 0.36 1.89e-11 Response to antipsychotic treatment; CRC cis rs6793245 0.801 rs41315485 chr3:38590275 A/G cg01465620 chr3:38496096 LOC100128640;ACVR2B -0.46 -5.66 -0.3 3.28e-8 QT interval; CRC cis rs2522056 0.808 rs17771891 chr5:131744202 A/G cg12564285 chr5:131593104 PDLIM4 0.38 5.65 0.3 3.55e-8 Lymphocyte counts;Fibrinogen; CRC cis rs7715806 0.500 rs17563589 chr5:74980019 A/G cg00601450 chr5:74908170 NA 0.45 5.64 0.3 3.73e-8 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs11098499 0.909 rs7681214 chr4:120385320 C/A cg24375607 chr4:120327624 NA 0.5 7.72 0.39 1.4e-13 Corneal astigmatism; CRC cis rs832540 0.656 rs2408597 chr5:56098632 G/A cg24531977 chr5:56204891 C5orf35 -0.5 -7.56 -0.38 4.12e-13 Coronary artery disease; CRC cis rs11969893 0.850 rs9485417 chr6:101300038 C/T cg12253828 chr6:101329408 ASCC3 -1.19 -9.37 -0.46 1.17e-18 Economic and political preferences (immigration/crime); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg11064558 chr21:43430383 ZNF295 0.43 6.01 0.31 4.91e-9 Response to antipsychotic treatment; CRC cis rs5750830 0.594 rs1010169 chr22:39778167 C/T cg05872129 chr22:39784769 NA 0.55 9.98 0.48 1.12e-20 Intelligence (multi-trait analysis); CRC cis rs7618915 0.570 rs11130312 chr3:52675055 A/C cg05573699 chr3:52720067 GNL3;PBRM1 -0.47 -6.68 -0.35 1.02e-10 Bipolar disorder; CRC cis rs11971779 0.680 rs2355787 chr7:139089928 G/T cg07862535 chr7:139043722 LUC7L2 -0.59 -7.64 -0.39 2.4e-13 Diisocyanate-induced asthma; CRC cis rs9372498 0.536 rs62424195 chr6:118812108 T/A cg22561889 chr6:118971681 C6orf204 0.51 6.6 0.34 1.68e-10 Diastolic blood pressure; CRC cis rs832540 0.931 rs2591960 chr5:56238811 A/T cg12311346 chr5:56204834 C5orf35 0.57 8.69 0.43 1.71e-16 Coronary artery disease; CRC cis rs72781680 0.800 rs72780112 chr2:23991182 C/T cg08917208 chr2:24149416 ATAD2B 0.87 8.46 0.42 8.88e-16 Lymphocyte counts; CRC cis rs1670533 1.000 rs6836350 chr4:1069973 C/T cg27284194 chr4:1044797 NA 0.5 6.39 0.33 5.61e-10 Recombination rate (females); CRC cis rs3741404 0.895 rs1860368 chr11:63994692 T/C cg18225595 chr11:63971243 STIP1 -0.55 -9.04 -0.45 1.38e-17 Platelet count; CRC trans rs2303319 0.504 rs58622044 chr2:162596287 A/G cg10272801 chr16:14013773 ERCC4 -0.69 -6.16 -0.32 2.15e-9 Cognitive function; CRC cis rs35306767 0.761 rs11253559 chr10:1044809 T/C cg26597838 chr10:835615 NA 0.94 11.17 0.52 8.94e-25 Eosinophil percentage of granulocytes; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg19078334 chr9:113019254 TXN 0.42 6.08 0.32 3.42e-9 Intelligence (multi-trait analysis); CRC trans rs6561151 0.718 rs11842000 chr13:44413467 T/C cg17145862 chr1:211918768 LPGAT1 0.53 6.19 0.32 1.77e-9 Crohn's disease; CRC cis rs9303280 0.806 rs13380815 chr17:38027583 A/G cg20243544 chr17:37824526 PNMT 0.38 5.73 0.3 2.28e-8 Self-reported allergy; CRC cis rs17155006 0.746 rs430628 chr7:107746214 T/G cg05962710 chr7:107745446 LAMB4 -0.41 -7.44 -0.38 8.61e-13 Pneumococcal bacteremia; CRC cis rs28386778 0.701 rs2727337 chr17:61991966 G/A cg06873352 chr17:61820015 STRADA -0.67 -11.84 -0.55 3.39e-27 Prudent dietary pattern; CRC cis rs77633900 0.614 rs280005 chr15:77009185 G/C cg21673338 chr15:77095150 SCAPER -0.77 -8.19 -0.41 5.79e-15 Non-glioblastoma glioma;Glioma; CRC trans rs11098499 1.000 rs58601355 chr4:120186367 T/C cg25214090 chr10:38739885 LOC399744 0.52 8.05 0.41 1.5e-14 Corneal astigmatism; CRC trans rs116095464 0.558 rs2288459 chr5:231143 T/C cg00938859 chr5:1591904 SDHAP3 0.72 7.94 0.4 3.15e-14 Breast cancer; CRC cis rs910316 1.000 rs10873275 chr14:75531460 A/T cg03030879 chr14:75389066 RPS6KL1 -0.46 -7.14 -0.37 6.1e-12 Height; CRC cis rs7481584 0.624 rs451060 chr11:3056389 G/A cg25174290 chr11:3078921 CARS -0.42 -5.82 -0.31 1.39e-8 Calcium levels; CRC cis rs875971 0.540 rs4717275 chr7:65265180 C/T cg11764359 chr7:65958608 NA -0.52 -7.98 -0.4 2.51e-14 Aortic root size; CRC cis rs17376456 0.757 rs1031424 chr5:93139706 G/C cg25358565 chr5:93447407 FAM172A 1.01 10.15 0.49 3.01e-21 Diabetic retinopathy; CRC cis rs477692 0.699 rs509017 chr10:131367174 T/G cg05714579 chr10:131428358 MGMT 0.49 6.98 0.36 1.68e-11 Response to temozolomide; CRC cis rs911119 0.955 rs2067488 chr20:23594331 T/G cg16589663 chr20:23618590 CST3 0.44 6.17 0.32 1.96e-9 Chronic kidney disease; CRC cis rs1008375 0.898 rs4698623 chr4:17594702 T/C cg16339924 chr4:17578868 LAP3 0.6 7.92 0.4 3.63e-14 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs1218582 0.682 rs12046459 chr1:154912017 A/C cg06221963 chr1:154839813 KCNN3 -0.77 -15.11 -0.64 1.49e-39 Prostate cancer; CRC cis rs2996428 0.667 rs7511793 chr1:3744249 A/G cg17848003 chr1:3704513 LRRC47 0.4 5.81 0.31 1.47e-8 Red cell distribution width; CRC cis rs6696846 0.630 rs6692706 chr1:205158561 G/T cg00857998 chr1:205179979 DSTYK 0.51 6.95 0.36 1.92e-11 Red blood cell count; CRC cis rs870825 0.550 rs10000507 chr4:185619281 C/T cg04058563 chr4:185651563 MLF1IP 0.72 9.47 0.46 5.62e-19 Blood protein levels; CRC cis rs78472555 1.000 rs11247124 chr15:100265725 C/T cg18869061 chr15:100272053 LYSMD4 -0.54 -6.84 -0.35 3.83e-11 Post bronchodilator FEV1/FVC ratio in COPD; CRC cis rs796364 1.000 rs281794 chr2:200846666 C/T cg25936922 chr2:200820526 C2orf60;C2orf47 0.73 7.97 0.4 2.71e-14 Schizophrenia; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg10878768 chr1:33430605 RNF19B 0.43 6.16 0.32 2.1e-9 Response to antipsychotic treatment; CRC cis rs909002 0.772 rs12740754 chr1:32083273 G/C cg13919466 chr1:32135498 COL16A1 -0.31 -5.81 -0.31 1.46e-8 Intelligence (multi-trait analysis); CRC cis rs6088580 0.668 rs1205337 chr20:32926041 T/A cg24642439 chr20:33292090 TP53INP2 -0.4 -6.78 -0.35 5.44e-11 Glomerular filtration rate (creatinine); CRC cis rs243505 0.559 rs7802887 chr7:148494758 C/T cg09806900 chr7:148480153 CUL1 0.56 7.91 0.4 3.88e-14 Inflammatory bowel disease;Crohn's disease; CRC cis rs6089584 0.816 rs6061411 chr20:60634716 C/A cg06108461 chr20:60628389 TAF4 -0.89 -15.17 -0.64 9.25e-40 Body mass index; CRC cis rs11168351 0.591 rs4258439 chr12:48468652 A/G cg21466736 chr12:48725269 NA 0.51 7.97 0.4 2.6e-14 Bipolar disorder and schizophrenia; CRC cis rs72945132 0.882 rs7940090 chr11:70227824 C/G cg14191688 chr11:70257035 CTTN 0.4 5.65 0.3 3.55e-8 Coronary artery disease; CRC trans rs877282 0.945 rs10904556 chr10:789429 A/G cg22713356 chr15:30763199 NA 1.33 16.09 0.66 2.34e-43 Uric acid levels; CRC cis rs2456568 0.805 rs2032400 chr11:93676937 G/A cg26875233 chr11:93583750 C11orf90 -0.34 -6.64 -0.34 1.28e-10 Response to serotonin reuptake inhibitors in major depressive disorder; CRC cis rs2976388 0.566 rs13250661 chr8:143804134 C/T cg10596483 chr8:143751796 JRK -0.45 -6.27 -0.33 1.14e-9 Urinary tract infection frequency; CRC cis rs13108904 0.901 rs4974594 chr4:1300480 C/T cg20887711 chr4:1340912 KIAA1530 -0.42 -5.98 -0.31 5.78e-9 Obesity-related traits; CRC cis rs9443189 0.570 rs6903448 chr6:76173832 C/T cg01950844 chr6:76311363 SENP6 0.65 8.41 0.42 1.25e-15 Prostate cancer; CRC trans rs6550704 0.687 rs9865314 chr3:22634337 A/G cg27304813 chr3:120068385 LRRC58 -0.4 -6.04 -0.32 4.13e-9 Daytime sleep phenotypes; CRC cis rs311392 0.554 rs311386 chr8:55101507 A/G cg06042504 chr8:55087323 NA -0.36 -5.72 -0.3 2.35e-8 Pelvic organ prolapse (moderate/severe); CRC cis rs1707322 0.752 rs11211168 chr1:46163647 C/T cg06784218 chr1:46089804 CCDC17 0.65 12.1 0.55 4.01e-28 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC trans rs2271001 0.518 rs905551 chr11:19096299 C/G cg23684973 chr10:1780003 ADARB2 0.35 6.1 0.32 3.02e-9 Gut microbiome composition (winter); CRC cis rs2354432 0.607 rs1530335 chr1:146685288 T/C cg25205988 chr1:146714368 CHD1L 1.07 9.25 0.45 2.99e-18 Mitochondrial DNA levels; CRC cis rs8114671 0.836 rs6120778 chr20:33565169 T/C cg07148914 chr20:33460835 GGT7 0.36 5.69 0.3 2.8e-8 Height; CRC cis rs910316 0.967 rs35446981 chr14:75637351 A/T cg11812906 chr14:75593930 NEK9 -0.62 -9.57 -0.47 2.68e-19 Height; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg02128655 chr19:17186722 MYO9B;HAUS8 0.39 5.97 0.31 6.07e-9 Liver disease severity in Alagille syndrome; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg04568155 chr16:14724289 PARN 0.48 6.66 0.34 1.14e-10 Response to antipsychotic treatment; CRC trans rs7618501 0.633 rs6772095 chr3:49978069 C/T cg21665057 chr3:196295764 WDR53;FBXO45 0.61 9.53 0.47 3.56e-19 Intelligence (multi-trait analysis); CRC cis rs72781680 0.898 rs55841168 chr2:24007926 T/C cg08917208 chr2:24149416 ATAD2B 0.84 8.11 0.41 1e-14 Lymphocyte counts; CRC cis rs4862750 0.914 rs9995391 chr4:187873749 A/T cg06074448 chr4:187884817 NA 0.57 10.32 0.49 8.21e-22 Lobe attachment (rater-scored or self-reported); CRC cis rs17270561 0.779 rs78589800 chr6:25883500 C/G cg16482183 chr6:26056742 HIST1H1C 0.87 11.04 0.52 2.54e-24 Iron status biomarkers; CRC cis rs947211 0.950 rs1775145 chr1:205756143 C/A cg07167872 chr1:205819463 PM20D1 0.45 6.18 0.32 1.93e-9 Parkinson's disease; CRC cis rs12928939 0.723 rs34053338 chr16:71849974 C/T cg03805757 chr16:71968109 PKD1L3 -0.48 -6.05 -0.32 3.83e-9 Post bronchodilator FEV1; CRC cis rs394563 0.690 rs237009 chr6:149759552 C/T cg07828024 chr6:149772892 ZC3H12D -0.54 -10.03 -0.48 7.77e-21 Dupuytren's disease; CRC cis rs1707322 0.752 rs12047629 chr1:46162802 G/A cg03146154 chr1:46216737 IPP 0.67 9.73 0.47 7.77e-20 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs6502050 0.835 rs4789665 chr17:80168097 A/C cg19223190 chr17:80058835 NA 0.41 6.59 0.34 1.78e-10 Life satisfaction; CRC cis rs11628318 0.853 rs7140280 chr14:103026991 C/T cg08075719 chr14:103021372 NA -0.48 -6.39 -0.33 5.65e-10 Platelet count; CRC cis rs2304069 0.817 rs216132 chr5:149431259 C/T cg22760475 chr5:149380129 HMGXB3;TIGD6 -0.69 -8.25 -0.41 3.81e-15 HIV-1 control; CRC cis rs200986 1 rs200986 chr6:27824766 G/C cg02683197 chr6:28174875 NA 0.68 9.47 0.46 5.81e-19 Autism spectrum disorder or schizophrenia; CRC cis rs3760982 0.585 rs1386502 chr19:44293356 T/C cg11993925 chr19:44307056 LYPD5 0.56 9.92 0.48 1.78e-20 Breast cancer (estrogen-receptor negative);Breast cancer; CRC cis rs9372498 0.536 rs62421539 chr6:118730559 C/A cg24463073 chr6:118973353 C6orf204 0.5 6.69 0.35 9.8e-11 Diastolic blood pressure; CRC cis rs11864453 0.713 rs6680 chr16:72146570 T/C cg01557791 chr16:72042693 DHODH -0.43 -6.05 -0.32 4.04e-9 Fibrinogen levels; CRC cis rs990171 1.000 rs3755274 chr2:103002395 A/G cg03938978 chr2:103052716 IL18RAP 0.46 5.82 0.31 1.37e-8 Lymphocyte counts; CRC cis rs66573146 1.000 rs66519732 chr4:6990569 C/G cg00086871 chr4:6988644 TBC1D14 0.92 6.89 0.35 2.9e-11 Granulocyte percentage of myeloid white cells; CRC cis rs34375054 0.624 rs7132026 chr12:125678096 A/G cg25124228 chr12:125621409 AACS 0.52 6.9 0.36 2.67e-11 Post bronchodilator FEV1/FVC ratio; CRC cis rs6089584 0.888 rs6061983 chr20:60621202 T/C cg06108461 chr20:60628389 TAF4 -0.92 -15.9 -0.66 1.28e-42 Body mass index; CRC cis rs9292777 0.805 rs12659057 chr5:40414875 A/G cg09067459 chr5:40385259 NA 0.51 8.86 0.44 4.94e-17 Crohn's disease;Multiple sclerosis; CRC cis rs8177253 0.763 rs6797713 chr3:133474832 T/C cg16262614 chr3:133464971 TF 0.37 6.34 0.33 7.45e-10 Iron status biomarkers; CRC cis rs6545883 0.929 rs12713436 chr2:61691260 T/C cg15711740 chr2:61764176 XPO1 -0.45 -5.91 -0.31 8.68e-9 Tuberculosis; CRC cis rs2839186 0.708 rs6518285 chr21:47644667 T/C cg05896524 chr21:47604654 C21orf56 0.48 7.31 0.37 1.99e-12 Testicular germ cell tumor; CRC cis rs3768617 0.811 rs4285667 chr1:182970225 T/A ch.1.3577855R chr1:183094577 LAMC1 0.61 9.0 0.44 1.91e-17 Fuchs's corneal dystrophy; CRC cis rs2506889 0.553 rs7548453 chr1:10589836 A/G cg17425144 chr1:10567563 PEX14 0.54 12.34 0.56 5.15e-29 Breast cancer; CRC cis rs875971 0.522 rs56028712 chr7:65466565 C/T cg00343986 chr7:65444356 GUSB 0.57 8.61 0.43 3.11e-16 Aortic root size; CRC cis rs9910055 0.821 rs4473241 chr17:42281282 G/T cg09913183 chr17:42254507 C17orf65;ASB16 0.53 7.98 0.4 2.47e-14 Total body bone mineral density; CRC cis rs875971 0.862 rs7782704 chr7:65805366 G/A cg18876405 chr7:65276391 NA -0.52 -8.56 -0.43 4.45e-16 Aortic root size; CRC cis rs3749237 0.595 rs3870338 chr3:49557051 A/G cg03060546 chr3:49711283 APEH 0.6 10.24 0.49 1.56e-21 Resting heart rate; CRC cis rs9311676 0.656 rs62258134 chr3:58398447 C/T cg06643156 chr3:58380774 PXK 0.42 6.38 0.33 5.84e-10 Systemic lupus erythematosus; CRC cis rs6456156 0.774 rs1012656 chr6:167525303 G/C cg07513332 chr6:167530253 CCR6 -0.4 -7.25 -0.37 2.93e-12 Primary biliary cholangitis; CRC cis rs6500602 0.701 rs8053770 chr16:4539030 T/A cg14951292 chr16:4525986 HMOX2;NMRAL1 0.65 9.39 0.46 1.05e-18 Schizophrenia; CRC cis rs274567 0.501 rs274571 chr5:131712125 A/G cg18301423 chr5:131593218 PDLIM4 -0.39 -6.53 -0.34 2.56e-10 Blood metabolite levels; CRC cis rs28386778 0.897 rs6504187 chr17:61917099 G/A cg06601766 chr17:61851465 DDX42;CCDC47 0.45 6.12 0.32 2.71e-9 Prudent dietary pattern; CRC cis rs6502050 0.835 rs6502077 chr17:80122966 G/C cg11859384 chr17:80120422 CCDC57 -0.36 -5.75 -0.3 2.06e-8 Life satisfaction; CRC cis rs7666738 0.830 rs11931166 chr4:99054187 A/T cg17366294 chr4:99064904 C4orf37 0.45 7.71 0.39 1.46e-13 Colonoscopy-negative controls vs population controls; CRC cis rs7113874 0.569 rs7131358 chr11:8558333 G/C cg02811074 chr11:8615871 STK33 -0.36 -6.1 -0.32 2.92e-9 Body mass index in physically active individuals;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs2066819 1.000 rs76466034 chr12:56719450 G/A cg26714650 chr12:56694279 CS -1.39 -11.42 -0.53 1.14e-25 Psoriasis vulgaris; CRC cis rs1862618 0.853 rs861283 chr5:56184610 C/T cg22800045 chr5:56110881 MAP3K1 0.62 6.64 0.34 1.29e-10 Initial pursuit acceleration; CRC cis rs9611519 0.780 rs9611542 chr22:41677317 C/T cg03806693 chr22:41940476 POLR3H -0.66 -8.71 -0.43 1.54e-16 Neuroticism; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg21011043 chr12:96252937 SNRPF 0.45 6.3 0.33 9.34e-10 Anxiety disorder; CRC cis rs727505 0.721 rs56069273 chr7:124768604 G/A cg23710748 chr7:124431027 NA -0.64 -11.26 -0.53 4.37e-25 Lewy body disease; CRC cis rs1107366 1.000 rs9873704 chr3:125901902 G/C cg08481491 chr3:125900108 ALDH1L1 -0.34 -5.97 -0.31 6.17e-9 Metabolite levels; CRC cis rs3771570 1.000 rs73002111 chr2:242277833 C/T cg21155796 chr2:242212141 HDLBP 0.64 6.97 0.36 1.72e-11 Prostate cancer; CRC cis rs10450586 0.863 rs6484284 chr11:27298890 C/T cg10370305 chr11:27303972 NA 0.38 6.23 0.32 1.42e-9 Total body bone mineral density; CRC cis rs12586317 0.547 rs2254990 chr14:35465565 T/C cg05294307 chr14:35346193 BAZ1A -0.73 -8.21 -0.41 5.01e-15 Psoriasis; CRC cis rs9916302 0.904 rs7501488 chr17:37576417 T/G cg03013999 chr17:37608204 MED1 0.47 7.31 0.37 2e-12 Glomerular filtration rate (creatinine); CRC cis rs7647973 1.000 rs7613491 chr3:49508976 T/C cg20833759 chr3:49053208 WDR6;DALRD3 -0.62 -9.13 -0.45 7.11e-18 Menarche (age at onset); CRC cis rs9902453 0.726 rs4795523 chr17:28176314 A/G cg26525008 chr17:28256777 EFCAB5;SSH2 0.74 12.11 0.56 3.5e-28 Coffee consumption (cups per day); CRC cis rs9837602 1.000 rs4279135 chr3:99733096 C/T cg07805332 chr3:99536008 MIR548G;C3orf26 -0.49 -6.37 -0.33 6.39e-10 Breast cancer; CRC cis rs10540 0.730 rs61876338 chr11:493730 A/G cg15790184 chr11:494944 RNH1 0.6 6.18 0.32 1.85e-9 Body mass index; CRC cis rs10484885 0.878 rs17763820 chr6:90569634 A/G cg13799429 chr6:90582589 CASP8AP2 -0.72 -7.71 -0.39 1.47e-13 QRS interval (sulfonylurea treatment interaction); CRC cis rs3106136 0.933 rs35718240 chr4:95164030 G/A cg11021082 chr4:95130006 SMARCAD1 -0.46 -6.68 -0.35 1e-10 Capecitabine sensitivity; CRC cis rs2281727 0.500 rs2169356 chr17:2138016 A/T cg16513277 chr17:2031491 SMG6 -0.53 -9.03 -0.45 1.52e-17 Coronary artery disease;Body mass index; CRC cis rs12681288 0.676 rs1562921 chr8:1021986 G/T cg04851639 chr8:1020857 NA -0.42 -8.5 -0.42 6.75e-16 Schizophrenia; CRC cis rs7725052 0.609 rs4957298 chr5:40455245 G/T cg09067459 chr5:40385259 NA -0.4 -6.68 -0.35 9.91e-11 Pediatric autoimmune diseases; CRC cis rs3106136 0.843 rs7438414 chr4:95265822 T/C cg11021082 chr4:95130006 SMARCAD1 0.41 6.17 0.32 2.04e-9 Capecitabine sensitivity; CRC cis rs11098499 0.754 rs7672594 chr4:120248543 A/C cg09307838 chr4:120376055 NA 0.62 9.71 0.47 9.4e-20 Corneal astigmatism; CRC cis rs17767392 0.829 rs35796129 chr14:71758598 G/A cg13720639 chr14:72061746 SIPA1L1 -0.54 -6.87 -0.35 3.2e-11 Mitral valve prolapse; CRC cis rs514406 0.895 rs1925673 chr1:53326984 T/G cg24675658 chr1:53192096 ZYG11B -0.57 -8.48 -0.42 7.78e-16 Monocyte count; CRC cis rs924607 1.000 rs924607 chr5:610093 C/T cg09021430 chr5:549028 NA 0.51 8.55 0.43 4.84e-16 Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia; CRC trans rs7555117 0.763 rs1461356 chr1:61037015 C/T cg16795821 chr3:142720237 SR140 -0.36 -6.02 -0.31 4.72e-9 Facial morphology (factor 19); CRC cis rs2204008 0.807 rs12816136 chr12:38456037 A/G cg26384229 chr12:38710491 ALG10B -0.67 -9.94 -0.48 1.51e-20 Bladder cancer; CRC trans rs9813712 0.597 rs11711883 chr3:129960210 C/T cg23942268 chr17:6347992 FAM64A -0.41 -6.01 -0.31 5.03e-9 Response to amphetamines; CRC cis rs79349575 0.783 rs12601955 chr17:47034420 C/T cg00947319 chr17:47005597 UBE2Z -0.34 -5.69 -0.3 2.83e-8 Type 2 diabetes; CRC trans rs13046373 0.905 rs4816372 chr21:32077414 A/T cg24331354 chr3:14444067 SLC6A6 -0.41 -6.0 -0.31 5.11e-9 HDL cholesterol; CRC cis rs17376456 0.877 rs10050465 chr5:93349963 C/A cg25358565 chr5:93447407 FAM172A 1.08 10.79 0.51 1.99e-23 Diabetic retinopathy; CRC cis rs1552244 0.832 rs61056817 chr3:10027641 C/T cg00166722 chr3:10149974 C3orf24 0.58 7.04 0.36 1.15e-11 Alzheimer's disease; CRC cis rs7849270 1.000 rs3124514 chr9:131904608 C/T cg13538475 chr9:131942899 NA 0.33 6.23 0.33 1.4e-9 Blood metabolite ratios; CRC cis rs891088 0.695 rs35296670 chr19:7198004 G/A cg09779027 chr19:7224513 INSR -0.61 -7.47 -0.38 7.43e-13 Hip circumference adjusted for BMI;Height; CRC cis rs7680126 0.672 rs10939819 chr4:10290661 T/C cg00071950 chr4:10020882 SLC2A9 -0.44 -5.97 -0.31 6.23e-9 Urate levels in lean individuals;Urate levels in overweight individuals;Urate levels in obese individuals; CRC cis rs9549328 0.642 rs2993343 chr13:113616844 C/G cg17524180 chr13:113633600 MCF2L 0.52 9.24 0.45 3.04e-18 Systolic blood pressure; CRC trans rs2303319 0.504 rs1006428 chr2:162592559 A/C cg18122310 chr12:50236657 BCDIN3D -0.73 -6.35 -0.33 7.23e-10 Cognitive function; CRC trans rs6693295 0.605 rs4396095 chr1:246213270 A/G cg17980625 chr11:94965587 SESN3 0.48 6.05 0.32 3.9e-9 Migraine - clinic-based;Migraine with aura; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg21860679 chr12:89745673 DUSP6 0.45 6.14 0.32 2.42e-9 Anxiety disorder; CRC trans rs2228479 0.850 rs17226980 chr16:89825065 G/A cg24644049 chr4:85504048 CDS1 0.86 6.93 0.36 2.29e-11 Skin colour saturation; CRC cis rs12325245 0.536 rs12931124 chr16:58620063 G/A cg21335942 chr16:58549945 SETD6 0.85 5.69 0.3 2.79e-8 Schizophrenia; CRC cis rs1577917 1.000 rs12204015 chr6:86598334 C/A cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.5 -6.51 -0.34 2.79e-10 Response to antipsychotic treatment; CRC cis rs6502050 0.835 rs12945993 chr17:80129485 T/C cg25804541 chr17:80189381 SLC16A3 -0.3 -5.75 -0.3 2.07e-8 Life satisfaction; CRC cis rs4713118 0.539 rs200967 chr6:27862127 A/G cg10876282 chr6:28092338 ZSCAN16 0.46 6.1 0.32 2.94e-9 Parkinson's disease; CRC cis rs3785574 0.962 rs7219920 chr17:61811642 C/G cg25654072 chr17:61904446 PSMC5;FTSJ3 0.42 5.9 0.31 9.27e-9 Height; CRC cis rs875971 1.000 rs6958271 chr7:65979331 A/C cg11764359 chr7:65958608 NA 0.63 10.26 0.49 1.3e-21 Aortic root size; CRC trans rs9329221 0.527 rs10903328 chr8:10332167 G/C cg08975724 chr8:8085496 FLJ10661 0.4 6.0 0.31 5.2e-9 Neuroticism; CRC cis rs8102476 0.905 rs7250689 chr19:38753625 C/T cg14131526 chr19:38747285 PPP1R14A 0.36 6.38 0.33 6.05e-10 Prostate cancer;Prostate cancer (SNP x SNP interaction); CRC cis rs7762018 0.941 rs4716384 chr6:170109184 T/A cg17545662 chr6:170176663 C6orf70 0.53 5.82 0.31 1.37e-8 Thiazide-induced adverse metabolic effects in hypertensive patients; CRC trans rs916888 0.821 rs199512 chr17:44857352 T/C cg10053473 chr17:62856997 LRRC37A3 0.71 8.39 0.42 1.42e-15 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs2242116 0.833 rs6442038 chr3:46960742 A/G cg02527881 chr3:46936655 PTH1R -0.46 -7.96 -0.4 2.85e-14 Birth weight; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg02010524 chr4:57333365 SRP72 0.42 6.0 0.31 5.07e-9 Intelligence (multi-trait analysis); CRC cis rs6952808 0.500 rs3778996 chr7:2177190 G/A cg21782813 chr7:2030301 MAD1L1 0.5 8.42 0.42 1.16e-15 Bipolar disorder and schizophrenia; CRC cis rs7666738 0.830 rs17558151 chr4:99048699 T/C cg05340658 chr4:99064831 C4orf37 0.58 8.91 0.44 3.67e-17 Colonoscopy-negative controls vs population controls; CRC cis rs4555082 0.834 rs2816653 chr14:105713973 A/G cg10792982 chr14:105748885 BRF1 0.33 5.65 0.3 3.5e-8 Mean platelet volume;Platelet distribution width; CRC cis rs2880765 0.835 rs7180923 chr15:86050890 A/T cg17133734 chr15:86042851 AKAP13 0.4 6.53 0.34 2.5e-10 Coronary artery disease; CRC cis rs116095464 0.558 rs7715108 chr5:264661 A/G cg22496380 chr5:211416 CCDC127 -0.91 -10.46 -0.5 2.65e-22 Breast cancer; CRC cis rs6840360 1.000 rs3749561 chr4:152610117 C/T cg22705602 chr4:152727874 NA 0.34 5.63 0.3 3.95e-8 Intelligence (multi-trait analysis); CRC cis rs9467711 0.659 rs72845428 chr6:26550144 C/T cg12315302 chr6:26189340 HIST1H4D 0.99 6.93 0.36 2.22e-11 Autism spectrum disorder or schizophrenia; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg21306212 chr13:79979929 RBM26 0.45 6.5 0.34 2.96e-10 Response to antipsychotic treatment; CRC cis rs853679 0.598 rs9380054 chr6:28067537 G/A cg06470822 chr6:28175283 NA 1.0 13.33 0.59 1.04e-32 Depression; CRC cis rs35883536 1.000 rs3904672 chr1:101136651 C/T cg14515779 chr1:101123966 NA -0.43 -8.31 -0.42 2.46e-15 Monocyte count; CRC cis rs853679 0.517 rs1904841 chr6:28108085 C/T cg21251018 chr6:28226885 NKAPL 0.47 6.16 0.32 2.1e-9 Depression; CRC cis rs796364 0.951 rs3098341 chr2:200792498 G/T cg25936922 chr2:200820526 C2orf60;C2orf47 0.7 7.65 0.39 2.21e-13 Schizophrenia; CRC cis rs11098499 0.754 rs714899 chr4:120243035 G/A cg09307838 chr4:120376055 NA 0.62 9.71 0.47 9.32e-20 Corneal astigmatism; CRC cis rs7589728 1.000 rs7425670 chr2:88522028 C/T cg07952391 chr2:88470173 THNSL2 0.6 6.24 0.33 1.32e-9 Plasma clusterin levels; CRC cis rs3772130 0.962 rs6789736 chr3:121543084 T/G cg20356878 chr3:121714668 ILDR1 0.51 7.99 0.4 2.3e-14 Cognitive performance; CRC trans rs2243480 1.000 rs709607 chr7:65449541 C/G cg10756647 chr7:56101905 PSPH -0.66 -7.61 -0.39 2.95e-13 Diabetic kidney disease; CRC cis rs9381040 0.610 rs2268191 chr6:41027653 G/C cg03644281 chr6:41068752 NFYA;LOC221442 -0.44 -6.37 -0.33 6.24e-10 Alzheimer's disease (late onset); CRC trans rs3942852 0.594 rs10769311 chr11:48094009 T/C cg03929089 chr4:120376271 NA -0.6 -8.4 -0.42 1.38e-15 Acute lymphoblastic leukemia (childhood); CRC cis rs9926296 0.744 rs154657 chr16:89708096 A/G cg01097406 chr16:89675127 NA -0.51 -9.28 -0.46 2.4e-18 Vitiligo; CRC trans rs7618501 0.521 rs868891 chr3:49949071 A/G cg21659725 chr3:3221576 CRBN 0.46 6.63 0.34 1.34e-10 Intelligence (multi-trait analysis); CRC cis rs561341 1.000 rs113115092 chr17:30284164 G/A cg12193833 chr17:30244370 NA -0.74 -8.72 -0.43 1.45e-16 Hip circumference adjusted for BMI; CRC cis rs7224685 0.501 rs7222628 chr17:3890429 A/G cg05562828 chr17:3906858 NA 0.72 13.48 0.6 2.89e-33 Type 2 diabetes; CRC cis rs12540874 0.542 rs4947582 chr7:50566090 C/T cg18232548 chr7:50535776 DDC -0.48 -7.22 -0.37 3.58e-12 Systemic sclerosis; CRC cis rs7103648 0.618 rs11039284 chr11:47564785 A/G cg20307385 chr11:47447363 PSMC3 0.82 11.77 0.54 6.14e-27 Diastolic blood pressure;Systolic blood pressure; CRC cis rs11587400 0.656 rs6689415 chr1:115107469 G/T cg12756093 chr1:115239321 AMPD1 0.44 6.06 0.32 3.77e-9 Autism; CRC cis rs3204270 0.759 rs77740144 chr17:79608968 G/A cg09655341 chr17:79618100 PDE6G 0.64 7.65 0.39 2.29e-13 Dental caries; CRC cis rs561341 0.739 rs6505267 chr17:30225950 A/C cg13647721 chr17:30228624 UTP6 0.61 7.21 0.37 3.94e-12 Hip circumference adjusted for BMI; CRC cis rs1003719 0.680 rs8130069 chr21:38552116 A/G cg10648535 chr21:38446584 PIGP;TTC3 -0.48 -6.67 -0.35 1.09e-10 Eye color traits; CRC cis rs748404 0.660 rs693510 chr15:43714625 C/G cg15269541 chr15:43626905 ADAL -0.36 -5.64 -0.3 3.7e-8 Lung cancer; CRC cis rs10256972 0.552 rs2949195 chr7:1202705 G/A cg07092213 chr7:1199455 ZFAND2A -0.48 -6.87 -0.35 3.19e-11 Longevity;Endometriosis; CRC cis rs1728785 0.901 rs1645934 chr16:68564490 T/A cg02972257 chr16:68554789 NA -0.58 -7.08 -0.36 9.03e-12 Ulcerative colitis; CRC cis rs2180341 0.782 rs4487601 chr6:127723521 A/G cg24812749 chr6:127587940 RNF146 0.68 9.21 0.45 4.07e-18 Breast cancer; CRC cis rs950173 1.000 rs950173 chr2:172570419 G/A cg13550731 chr2:172543902 DYNC1I2 -0.77 -6.11 -0.32 2.81e-9 Hippocampal volume; CRC cis rs9368481 0.546 rs12664610 chr6:26885031 G/A cg05192639 chr6:26864778 GUSBL1 0.34 6.07 0.32 3.62e-9 Autism spectrum disorder or schizophrenia; CRC cis rs2239547 0.522 rs2581805 chr3:52979050 T/C cg11645453 chr3:52864694 ITIH4 -0.52 -9.11 -0.45 8.43e-18 Schizophrenia; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg11179286 chr13:115047994 UPF3A 0.39 6.03 0.32 4.29e-9 Liver disease severity in Alagille syndrome; CRC cis rs10256972 0.591 rs11766651 chr7:1161646 A/G cg27094323 chr7:1216898 NA -0.4 -6.47 -0.34 3.65e-10 Longevity;Endometriosis; CRC cis rs4843747 0.697 rs72818533 chr16:88073841 G/A cg03395651 chr16:88107091 BANP 0.55 7.29 0.37 2.31e-12 Menopause (age at onset); CRC cis rs3096299 0.754 rs2965816 chr16:89514183 G/T cg00750074 chr16:89608354 SPG7 0.48 7.41 0.38 1.08e-12 Multiple myeloma (IgH translocation); CRC cis rs853679 0.567 rs16894106 chr6:28400339 G/A cg21251018 chr6:28226885 NKAPL 0.42 6.11 0.32 2.78e-9 Depression; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg02641675 chr6:74363634 SLC17A5 0.44 7.01 0.36 1.38e-11 Liver disease severity in Alagille syndrome; CRC cis rs7666738 0.830 rs1426670 chr4:98923572 A/G cg17366294 chr4:99064904 C4orf37 0.43 7.28 0.37 2.43e-12 Colonoscopy-negative controls vs population controls; CRC cis rs9611565 0.659 rs9611610 chr22:41949259 A/G cg17554472 chr22:41940697 POLR3H -0.54 -5.65 -0.3 3.47e-8 Vitiligo; CRC cis rs11098699 0.821 rs13114886 chr4:124217302 T/A cg09941581 chr4:124220074 SPATA5 0.39 5.76 0.3 1.96e-8 Mosquito bite size; CRC cis rs4073416 0.508 rs7146993 chr14:66048872 A/G cg03016385 chr14:66212404 NA 0.45 6.09 0.32 3.18e-9 N-glycan levels; CRC cis rs2576037 0.526 rs658756 chr18:44431832 A/G cg23996704 chr18:44553084 KATNAL2 -0.34 -7.07 -0.36 9.52e-12 Personality dimensions; CRC cis rs7264396 0.887 rs4281980 chr20:34096581 T/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.38 -6.28 -0.33 1.07e-9 Total cholesterol levels; CRC cis rs7493 1.000 rs2158806 chr7:95051998 A/C cg04155289 chr7:94953770 PON1 -0.62 -7.71 -0.39 1.55e-13 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs2361710 0.704 rs12937349 chr17:78120320 G/C cg20811857 chr17:78079795 GAA -0.41 -6.61 -0.34 1.52e-10 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count;Immature fraction of reticulocytes; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg00692933 chr16:68877417 TMCO7 0.45 6.15 0.32 2.24e-9 Response to antipsychotic treatment; CRC cis rs9868809 0.505 rs9882549 chr3:48749358 C/T cg00383909 chr3:49044727 WDR6 0.79 8.2 0.41 5.45e-15 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; CRC cis rs17401966 0.540 rs11121557 chr1:10448260 T/G cg19773385 chr1:10388646 KIF1B -0.48 -7.58 -0.39 3.44e-13 Hepatocellular carcinoma; CRC cis rs7618915 0.547 rs34173654 chr3:52634605 T/C cg05573699 chr3:52720067 GNL3;PBRM1 -0.44 -6.27 -0.33 1.16e-9 Bipolar disorder; CRC cis rs2270875 0.736 rs7832443 chr8:132886443 C/T cg24184792 chr8:132919238 EFR3A 0.54 5.64 0.3 3.68e-8 Response to cholinesterase inhibitors in Alzheimer's disease; CRC cis rs311392 0.903 rs6993362 chr8:55089220 A/G cg06042504 chr8:55087323 NA -0.43 -6.78 -0.35 5.55e-11 Pelvic organ prolapse (moderate/severe); CRC cis rs1448094 0.512 rs11117061 chr12:86250916 G/A cg25456477 chr12:86230367 RASSF9 0.38 6.65 0.34 1.23e-10 Major depressive disorder; CRC cis rs6684514 0.542 rs11264472 chr1:156292366 A/G cg20302342 chr1:156215951 PAQR6 0.37 7.26 0.37 2.85e-12 Mean corpuscular hemoglobin concentration;Glycated hemoglobin levels; CRC cis rs7246657 0.882 rs6508719 chr19:37877419 A/G cg23950597 chr19:37808831 NA -0.47 -5.76 -0.3 1.95e-8 Coronary artery calcification; CRC cis rs7107174 0.901 rs2512522 chr11:77925855 G/C cg02023728 chr11:77925099 USP35 0.54 8.2 0.41 5.55e-15 Testicular germ cell tumor; CRC trans rs10842750 1.000 rs10842750 chr12:26690565 G/T ch.8.34907260F chr8:34787718 NA 0.53 6.28 0.33 1.09e-9 Kashin-Beck disease; CRC cis rs7772486 0.754 rs702319 chr6:146006117 T/C cg05347473 chr6:146136440 FBXO30 -0.4 -5.96 -0.31 6.36e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs4073416 0.518 rs8013442 chr14:65871861 A/G cg03016385 chr14:66212404 NA -0.43 -5.95 -0.31 6.94e-9 N-glycan levels; CRC trans rs7395662 0.654 rs12289625 chr11:48817242 A/G cg21153622 chr11:89784906 NA 0.44 7.01 0.36 1.34e-11 HDL cholesterol; CRC cis rs4321325 0.733 rs78516281 chr2:127944564 G/C cg11380483 chr2:127933992 NA 0.57 7.11 0.36 7.23e-12 Protein C levels; CRC trans rs6951245 0.554 rs58210047 chr7:1149381 G/A cg13565492 chr6:43139072 SRF -0.84 -10.4 -0.5 4.44e-22 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs7618915 0.621 rs6788993 chr3:52605136 T/C cg11645453 chr3:52864694 ITIH4 0.34 5.92 0.31 7.98e-9 Bipolar disorder; CRC cis rs9911578 0.935 rs7216698 chr17:57007495 G/A cg12560992 chr17:57184187 TRIM37 0.83 14.63 0.63 1.06e-37 Intelligence (multi-trait analysis); CRC cis rs2721195 0.654 rs4610795 chr8:145881333 C/T cg11211951 chr8:145729740 GPT -0.38 -6.69 -0.35 9.48e-11 Age at first birth; CRC cis rs1865760 0.964 rs3799373 chr6:25929173 A/C cg17691542 chr6:26056736 HIST1H1C 0.54 7.98 0.4 2.54e-14 Height; CRC cis rs1707322 0.721 rs11211165 chr1:46157906 C/T cg03146154 chr1:46216737 IPP 0.67 9.82 0.48 3.93e-20 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs28386778 0.897 rs894413 chr17:61916347 A/G cg06601766 chr17:61851465 DDX42;CCDC47 0.44 5.94 0.31 7.26e-9 Prudent dietary pattern; CRC cis rs561341 0.769 rs559228 chr17:30294527 T/C cg00745463 chr17:30367425 LRRC37B -0.9 -9.89 -0.48 2.27e-20 Hip circumference adjusted for BMI; CRC cis rs7580658 0.963 rs62157555 chr2:128107176 C/T cg09760422 chr2:128146352 NA -0.36 -6.92 -0.36 2.34e-11 Protein C levels; CRC cis rs3749237 0.964 rs7431078 chr3:49808190 G/A cg24308560 chr3:49941425 MST1R -0.43 -6.18 -0.32 1.85e-9 Resting heart rate; CRC cis rs9322193 0.923 rs2342857 chr6:150130673 G/A cg13206674 chr6:150067644 NUP43 0.57 8.08 0.41 1.27e-14 Lung cancer; CRC cis rs8072100 1.000 rs8065437 chr17:45721653 C/T cg08085267 chr17:45401833 C17orf57 -0.65 -10.59 -0.5 9.32e-23 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs6496667 0.779 rs2074582 chr15:91009177 A/G cg04176472 chr15:90893244 GABARAPL3 0.53 7.5 0.38 6.06e-13 Rheumatoid arthritis; CRC cis rs2839186 0.596 rs4819217 chr21:47644092 G/T cg26721908 chr21:47610096 LSS -0.41 -6.36 -0.33 6.85e-10 Testicular germ cell tumor; CRC cis rs6032067 0.929 rs13038355 chr20:43805555 C/T cg10761708 chr20:43804764 PI3 0.52 5.99 0.31 5.6e-9 Blood protein levels; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg04680037 chr1:33430483 RNF19B 0.41 5.96 0.31 6.38e-9 Intelligence (multi-trait analysis); CRC cis rs262150 0.574 rs2730273 chr7:158797754 A/C cg12590608 chr7:158785262 NA 0.37 6.51 0.34 2.75e-10 Facial morphology (factor 20); CRC cis rs12024301 0.557 rs16861241 chr1:183589167 C/T cg11505048 chr1:183622726 RGL1;APOBEC4 0.72 6.86 0.35 3.52e-11 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs7618915 0.571 rs6805539 chr3:52609710 T/A cg10802521 chr3:52805072 NEK4 -0.59 -9.13 -0.45 7.13e-18 Bipolar disorder; CRC cis rs9469890 0.604 rs78871484 chr6:34503677 T/C cg17674042 chr6:34482479 PACSIN1 -0.66 -7.76 -0.39 1.1e-13 Pubertal anthropometrics;Coronary artery disease; CRC cis rs6840360 1.000 rs10049991 chr4:152664163 A/T cg09659197 chr4:152720779 NA 0.52 11.42 0.53 1.18e-25 Intelligence (multi-trait analysis); CRC cis rs4332037 0.539 rs62444881 chr7:2052318 C/T cg25834613 chr7:1915315 MAD1L1 -0.44 -6.22 -0.32 1.5e-9 Bipolar disorder; CRC cis rs780096 0.546 rs2293572 chr2:27728777 C/G cg27432699 chr2:27873401 GPN1 0.6 9.21 0.45 3.88e-18 Total body bone mineral density; CRC cis rs3617 0.599 rs12487379 chr3:52895785 G/A cg15147215 chr3:52552868 STAB1 -0.45 -7.23 -0.37 3.49e-12 Red blood cell count;Autism spectrum disorder or schizophrenia; CRC cis rs9916302 0.706 rs8075737 chr17:37727316 C/T cg00129232 chr17:37814104 STARD3 0.55 7.1 0.36 7.89e-12 Glomerular filtration rate (creatinine); CRC cis rs4665809 1.000 rs12469163 chr2:26283587 T/C cg22920501 chr2:26401640 FAM59B -0.52 -7.11 -0.36 7.39e-12 Gut microbiome composition (summer); CRC cis rs67478160 0.609 rs6576003 chr14:104291330 C/A cg08213375 chr14:104286397 PPP1R13B 0.58 11.92 0.55 1.83e-27 Schizophrenia; CRC cis rs4234798 0.527 rs4689668 chr4:7249378 T/A cg18431297 chr4:7219810 SORCS2 0.5 8.23 0.41 4.43e-15 Insulin-like growth factors; CRC cis rs12701220 0.655 rs6463317 chr7:1159243 G/A cg26769984 chr7:1090371 C7orf50 0.55 8.11 0.41 1.01e-14 Bronchopulmonary dysplasia; CRC cis rs28386778 0.830 rs2597636 chr17:61876010 A/G cg06873352 chr17:61820015 STRADA 0.8 15.3 0.64 2.82e-40 Prudent dietary pattern; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg20118422 chr15:64455210 PPIB 0.41 6.76 0.35 6.42e-11 Liver disease severity in Alagille syndrome; CRC cis rs10504229 0.679 rs11786328 chr8:58039269 A/G cg02725872 chr8:58115012 NA -0.5 -6.93 -0.36 2.22e-11 Developmental language disorder (linguistic errors); CRC cis rs7044106 0.762 rs10760110 chr9:123412563 A/G cg14255062 chr9:123606675 PSMD5;LOC253039 -0.39 -5.76 -0.3 1.94e-8 Hip circumference adjusted for BMI; CRC cis rs4566357 0.539 rs10933164 chr2:227860671 A/G cg11843606 chr2:227700838 RHBDD1 -0.69 -8.64 -0.43 2.52e-16 Coronary artery disease; CRC cis rs9322193 0.962 rs9767122 chr6:150104689 T/G cg00933542 chr6:150070202 PCMT1 0.28 5.63 0.3 3.86e-8 Lung cancer; CRC cis rs910316 1.000 rs2268617 chr14:75608728 G/A cg11812906 chr14:75593930 NEK9 0.6 9.42 0.46 8.3e-19 Height; CRC cis rs6831352 0.918 rs2851253 chr4:100043505 G/T cg12011299 chr4:100065546 ADH4 -0.48 -9.23 -0.45 3.35e-18 Alcohol dependence; CRC cis rs6088580 0.634 rs1205336 chr20:32926336 G/A cg08999081 chr20:33150536 PIGU -0.65 -11.78 -0.54 5.63e-27 Glomerular filtration rate (creatinine); CRC cis rs4713118 0.869 rs9283883 chr6:27715470 T/A cg25164649 chr6:28176230 NA 0.61 8.56 0.43 4.36e-16 Parkinson's disease; CRC cis rs9308731 0.965 rs6758181 chr2:111886914 C/T cg04202892 chr2:111875749 ACOXL 0.35 5.66 0.3 3.25e-8 Chronic lymphocytic leukemia; CRC cis rs9611565 0.694 rs2142505 chr22:41820541 A/G cg06481639 chr22:41940642 POLR3H 0.52 5.7 0.3 2.61e-8 Vitiligo; CRC cis rs853679 0.599 rs149990 chr6:27998258 G/A cg06470822 chr6:28175283 NA 0.76 7.09 0.36 8.3e-12 Depression; CRC cis rs2108225 1.000 rs2108225 chr7:107453103 G/A cg18560240 chr7:107437656 SLC26A3 -0.58 -8.81 -0.44 7.58e-17 Ulcerative colitis; CRC cis rs875971 0.793 rs460678 chr7:65527200 C/G cg00343986 chr7:65444356 GUSB 0.45 6.64 0.34 1.28e-10 Aortic root size; CRC cis rs2303759 0.918 rs7251704 chr19:49890873 T/G cg24324837 chr19:49891574 CCDC155 0.57 7.96 0.4 2.87e-14 Multiple sclerosis; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg25765569 chr12:117175636 C12orf49;RNFT2 -0.43 -6.25 -0.33 1.25e-9 Myopia (pathological); CRC cis rs1448094 0.692 rs7958438 chr12:86326141 A/T cg02569458 chr12:86230093 RASSF9 0.47 7.97 0.4 2.55e-14 Major depressive disorder; CRC trans rs6550704 0.687 rs9865314 chr3:22634337 A/G cg05031797 chr17:60557085 TLK2 -0.43 -6.2 -0.32 1.66e-9 Daytime sleep phenotypes; CRC cis rs1448094 1.000 rs10083080 chr12:86348579 G/C cg19622623 chr12:86230825 RASSF9 -0.37 -6.06 -0.32 3.64e-9 Major depressive disorder; CRC cis rs1322512 1.000 rs9371620 chr6:152949230 T/G cg03415253 chr6:152958462 SYNE1 -0.42 -6.43 -0.33 4.53e-10 Tonometry; CRC cis rs17376456 0.825 rs35496867 chr5:93220400 T/C cg09848695 chr5:92956644 FAM172A;MIR2277 0.65 5.82 0.31 1.37e-8 Diabetic retinopathy; CRC cis rs10504229 0.775 rs72650869 chr8:58157923 T/A cg11062466 chr8:58055876 NA 0.45 6.01 0.31 4.87e-9 Developmental language disorder (linguistic errors); CRC cis rs13064411 0.696 rs6808394 chr3:113122524 T/G cg18753928 chr3:113234510 CCDC52 -0.63 -8.72 -0.43 1.39e-16 Response to simvastatin treatment (PCSK9 protein level change); CRC cis rs911119 0.866 rs4815223 chr20:23577112 C/A cg16589663 chr20:23618590 CST3 0.41 5.77 0.3 1.85e-8 Chronic kidney disease; CRC cis rs3768617 0.510 rs2027083 chr1:183088330 T/C ch.1.3577855R chr1:183094577 LAMC1 0.89 15.86 0.66 1.84e-42 Fuchs's corneal dystrophy; CRC cis rs7666738 0.753 rs13122897 chr4:98936185 C/A cg17366294 chr4:99064904 C4orf37 0.43 7.32 0.37 1.95e-12 Colonoscopy-negative controls vs population controls; CRC cis rs4713118 0.662 rs464312 chr6:27967591 T/A cg12172441 chr6:28176163 NA 0.54 7.43 0.38 9.55e-13 Parkinson's disease; CRC cis rs9378357 0.850 rs7770256 chr6:3294153 G/A cg08754725 chr6:3293098 SLC22A23 -0.81 -7.52 -0.38 5.41e-13 Obesity-related traits; CRC cis rs8141797 0.901 rs5760236 chr22:24572034 G/A cg20894457 chr22:24584366 SUSD2 0.66 6.51 0.34 2.77e-10 Amyotrophic lateral sclerosis;Coronary artery disease; CRC cis rs7615952 0.599 rs16834938 chr3:125706046 C/T cg18479299 chr3:125709523 NA -0.49 -5.96 -0.31 6.46e-9 Blood pressure (smoking interaction); CRC trans rs8073060 0.586 rs7212488 chr17:33993476 A/T cg19694781 chr19:47549865 TMEM160 -1.1 -15.87 -0.66 1.67e-42 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; CRC cis rs868036 1.000 rs1871307 chr15:68100623 C/T cg05925327 chr15:68127851 NA -0.31 -6.0 -0.31 5.18e-9 Restless legs syndrome; CRC cis rs9916302 0.851 rs11078907 chr17:37662954 C/T cg00129232 chr17:37814104 STARD3 -0.55 -8.16 -0.41 6.96e-15 Glomerular filtration rate (creatinine); CRC cis rs4132509 1.000 rs12116882 chr1:243959106 G/A cg21452805 chr1:244014465 NA 0.51 6.81 0.35 4.58e-11 RR interval (heart rate); CRC cis rs73206853 0.686 rs60439011 chr12:110909179 T/C cg12870014 chr12:110450643 ANKRD13A 0.84 9.77 0.47 5.83e-20 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC cis rs2304069 0.545 rs12153714 chr5:149395254 A/G cg12661370 chr5:149340060 SLC26A2 0.43 6.21 0.32 1.62e-9 HIV-1 control; CRC cis rs7258465 1.000 rs4808801 chr19:18571141 A/G cg01065977 chr19:18549689 ISYNA1 -0.43 -6.76 -0.35 6.36e-11 Breast cancer; CRC cis rs3806843 1.000 rs6898939 chr5:140169355 C/A cg19875535 chr5:140030758 IK 0.6 9.78 0.47 5.17e-20 Depressive symptoms (multi-trait analysis); CRC cis rs7666738 0.830 rs7696568 chr4:99005333 A/T cg17366294 chr4:99064904 C4orf37 0.44 7.39 0.38 1.19e-12 Colonoscopy-negative controls vs population controls; CRC cis rs11122272 0.706 rs2749710 chr1:231535112 A/C cg06096015 chr1:231504339 EGLN1 -0.42 -6.33 -0.33 8.17e-10 Hemoglobin concentration; CRC cis rs2032447 0.798 rs807214 chr6:26061769 G/C cg26028573 chr6:26043587 HIST1H2BB 0.45 6.7 0.35 9.14e-11 Intelligence (multi-trait analysis); CRC cis rs9648716 1.000 rs6961127 chr7:140613952 G/T cg10747023 chr7:140774559 NA 0.47 6.1 0.32 2.98e-9 Type 2 diabetes; CRC cis rs3733585 0.781 rs13103879 chr4:9972879 T/C cg00071950 chr4:10020882 SLC2A9 -0.59 -10.65 -0.51 6.01e-23 Cleft plate (environmental tobacco smoke interaction); CRC cis rs58804349 0.581 rs12221397 chr10:43239833 A/G cg08461752 chr10:43522343 NA 0.77 6.16 0.32 2.12e-9 Pediatric bone mineral content (radius); CRC cis rs9814567 0.964 rs9847788 chr3:134186496 A/C cg06109529 chr3:134205091 CEP63;ANAPC13 -0.8 -11.79 -0.55 5.25e-27 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs875971 0.638 rs35986979 chr7:66088990 G/A cg18876405 chr7:65276391 NA -0.62 -11.15 -0.52 1.06e-24 Aortic root size; CRC trans rs2228479 0.850 rs17233664 chr16:89810628 C/T cg21302420 chr1:112162376 RAP1A 0.72 5.96 0.31 6.38e-9 Skin colour saturation; CRC cis rs832540 0.656 rs832567 chr5:56152416 C/A cg24531977 chr5:56204891 C5orf35 -0.53 -7.89 -0.4 4.38e-14 Coronary artery disease; CRC cis rs7811142 1.000 rs6979335 chr7:100089860 T/C cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.93 11.93 0.55 1.68e-27 Platelet count; CRC trans rs7873102 0.702 rs7028020 chr9:38007747 C/T cg25312474 chr6:142468512 VTA1 -0.42 -6.27 -0.33 1.17e-9 Brain structure; CRC cis rs77972916 0.611 rs6709988 chr2:43601317 C/T cg06169590 chr2:43455088 ZFP36L2;LOC100129726 -0.54 -6.45 -0.33 4.11e-10 Granulocyte percentage of myeloid white cells; CRC cis rs4242434 0.927 rs13264187 chr8:22506098 C/T cg03733263 chr8:22462867 KIAA1967 1.04 19.82 0.74 4.3e-58 Exploratory eye movement dysfunction in schizophrenia (cognitive search score); CRC cis rs1448094 0.511 rs2405623 chr12:86153466 G/A cg19622623 chr12:86230825 RASSF9 0.4 6.36 0.33 6.66e-10 Major depressive disorder; CRC cis rs17095355 1.000 rs12571674 chr10:111717608 C/T cg00817464 chr10:111662876 XPNPEP1 0.56 6.66 0.34 1.12e-10 Biliary atresia; CRC cis rs10924970 0.625 rs12044028 chr1:235492972 T/G cg09010748 chr1:235293032 TOMM20 -0.42 -5.86 -0.31 1.13e-8 Asthma; CRC cis rs6951245 1.000 rs28528096 chr7:1070912 G/C cg24642844 chr7:1081250 C7orf50 -0.78 -9.35 -0.46 1.42e-18 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs17209837 0.607 rs60040620 chr7:87085379 C/A cg00919237 chr7:87102261 ABCB4 -0.54 -7.09 -0.36 8.37e-12 Gallbladder cancer; CRC cis rs9296092 0.538 rs62405943 chr6:33517359 A/G cg13560919 chr6:33536144 NA -0.43 -5.98 -0.31 5.72e-9 Age at smoking initiation in chronic obstructive pulmonary disease; CRC cis rs9322193 0.923 rs62441303 chr6:150088683 A/G cg05861140 chr6:150128134 PCMT1 -0.44 -7.18 -0.37 4.53e-12 Lung cancer; CRC cis rs1018836 0.595 rs2223010 chr8:91480068 A/G cg16814680 chr8:91681699 NA -0.67 -10.28 -0.49 1.15e-21 Ejection fraction in Tripanosoma cruzi seropositivity; CRC trans rs7395662 0.963 rs11039772 chr11:48513892 T/A cg21153622 chr11:89784906 NA -0.45 -7.24 -0.37 3.11e-12 HDL cholesterol; CRC cis rs4819052 0.851 rs1999335 chr21:46670613 A/G cg11663144 chr21:46675770 NA -0.85 -14.82 -0.63 1.97e-38 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs908922 0.676 rs545418 chr1:152497338 C/T cg23254163 chr1:152506842 NA 0.5 10.11 0.49 4.05e-21 Hair morphology; CRC cis rs801193 0.548 rs7805152 chr7:66209253 C/T cg00343986 chr7:65444356 GUSB 0.44 6.16 0.32 2.13e-9 Aortic root size; CRC trans rs9968300 0.727 rs11728154 chr4:149660723 G/A cg17504397 chr17:38574575 TOP2A 0.55 6.02 0.31 4.54e-9 Plasma thyroid-stimulating hormone levels; CRC cis rs7493 1.000 rs2299263 chr7:95040411 A/G cg21856205 chr7:94953877 PON1 0.49 6.4 0.33 5.39e-10 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs7927592 0.956 rs7124078 chr11:68298633 G/T cg16797656 chr11:68205561 LRP5 0.37 5.84 0.31 1.25e-8 Total body bone mineral density; CRC cis rs17376456 0.877 rs10044139 chr5:93407803 T/C cg25358565 chr5:93447407 FAM172A 1.02 10.4 0.5 4.25e-22 Diabetic retinopathy; CRC cis rs6598955 0.724 rs869683 chr1:26570993 T/A cg00852783 chr1:26633632 UBXN11 0.43 7.04 0.36 1.15e-11 Obesity-related traits; CRC cis rs2072510 0.569 rs7970524 chr12:96390152 A/G cg22491680 chr12:96389547 HAL -0.46 -6.05 -0.32 3.93e-9 Metabolite levels (small molecules and protein measures); CRC cis rs7917772 0.582 rs10883736 chr10:104320029 G/T cg11453585 chr10:104263688 ACTR1A;SUFU 0.81 15.14 0.64 1.15e-39 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC cis rs4964805 0.526 rs934845 chr12:104185257 T/G cg02344784 chr12:104178138 NT5DC3 0.81 15.89 0.66 1.37e-42 Attention deficit hyperactivity disorder; CRC cis rs274567 0.550 rs272885 chr5:131667736 A/G cg18758796 chr5:131593413 PDLIM4 0.39 6.4 0.33 5.39e-10 Blood metabolite levels; CRC cis rs9467773 0.967 rs1535276 chr6:26520941 T/C cg09904177 chr6:26538194 HMGN4 0.86 14.6 0.63 1.44e-37 Intelligence (multi-trait analysis); CRC trans rs2303319 0.504 rs12470743 chr2:162611202 G/A cg22922770 chr7:98923339 ARPC1A -0.67 -5.98 -0.31 5.68e-9 Cognitive function; CRC cis rs6901250 0.807 rs1606366 chr6:117132438 C/G cg12892004 chr6:117198278 RFX6 0.45 7.02 0.36 1.27e-11 C-reactive protein levels; CRC cis rs7618915 0.571 rs1961958 chr3:52585990 A/G cg11645453 chr3:52864694 ITIH4 0.35 6.09 0.32 3.15e-9 Bipolar disorder; CRC cis rs6433857 0.657 rs2368178 chr2:181501938 T/C cg23363182 chr2:181467187 NA -0.58 -9.45 -0.46 6.48e-19 Body mass index; CRC cis rs9916302 0.904 rs9892055 chr17:37510402 C/T cg07936489 chr17:37558343 FBXL20 0.79 11.78 0.54 5.66e-27 Glomerular filtration rate (creatinine); CRC cis rs9443645 0.527 rs12527806 chr6:79507667 A/T cg05283184 chr6:79620031 NA -0.44 -6.36 -0.33 6.88e-10 Intelligence (multi-trait analysis); CRC cis rs7799006 0.755 rs12534131 chr7:2294123 C/T cg08027265 chr7:2291960 NA -0.49 -7.89 -0.4 4.5e-14 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs6951245 1.000 rs77083167 chr7:1071823 C/T cg20603222 chr7:1096387 C7orf50;GPR146 -0.69 -8.1 -0.41 1.07e-14 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs1707322 1.000 rs10890350 chr1:46262378 G/A cg03146154 chr1:46216737 IPP 0.52 7.31 0.37 2e-12 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs1003719 0.715 rs35199609 chr21:38510262 T/C cg10648535 chr21:38446584 PIGP;TTC3 -0.48 -6.65 -0.34 1.23e-10 Eye color traits; CRC cis rs6570726 1.000 rs951143 chr6:145932576 C/T cg05347473 chr6:146136440 FBXO30 0.37 5.7 0.3 2.7e-8 Lobe attachment (rater-scored or self-reported); CRC cis rs11690935 0.959 rs6705200 chr2:172637600 A/G cg13550731 chr2:172543902 DYNC1I2 -1.06 -18.36 -0.71 2.61e-52 Schizophrenia; CRC cis rs6952808 0.723 rs4721264 chr7:2012997 G/A cg22963979 chr7:1858916 MAD1L1 -0.52 -7.45 -0.38 8.51e-13 Bipolar disorder and schizophrenia; CRC cis rs6479527 0.806 rs10761308 chr9:96753643 A/G cg14459158 chr9:96720562 NA 0.41 7.64 0.39 2.36e-13 Esophageal adenocarcinoma; CRC cis rs1862618 0.853 rs832568 chr5:56153776 G/A cg22800045 chr5:56110881 MAP3K1 0.59 6.45 0.33 4.05e-10 Initial pursuit acceleration; CRC cis rs4665809 1.000 rs6546728 chr2:26276531 G/C cg04944784 chr2:26401820 FAM59B -0.66 -8.1 -0.41 1.06e-14 Gut microbiome composition (summer); CRC cis rs1153858 1.000 rs4774579 chr15:45651803 G/A cg14582100 chr15:45693742 SPATA5L1 0.29 6.11 0.32 2.89e-9 Homoarginine levels; CRC cis rs9372498 0.536 rs62424198 chr6:118827247 A/G cg15382696 chr6:118971807 C6orf204 0.61 7.91 0.4 4.08e-14 Diastolic blood pressure; CRC cis rs2816062 0.813 rs2745321 chr1:18889198 G/C cg18795169 chr1:18902165 NA -0.9 -18.56 -0.72 3.91e-53 Urate levels in lean individuals; CRC cis rs3617 0.573 rs2336668 chr3:52919096 G/T cg15147215 chr3:52552868 STAB1 0.43 7.23 0.37 3.5e-12 Red blood cell count;Autism spectrum disorder or schizophrenia; CRC cis rs66887589 0.748 rs28439855 chr4:120262256 G/A cg09307838 chr4:120376055 NA 0.56 8.69 0.43 1.7e-16 Diastolic blood pressure; CRC cis rs11864453 0.786 rs1050362 chr16:72130815 C/A cg23815491 chr16:72088622 HP 0.53 8.11 0.41 1.04e-14 Fibrinogen levels; CRC cis rs17270561 0.609 rs7772382 chr6:25708116 C/T cg17691542 chr6:26056736 HIST1H1C 0.63 7.98 0.4 2.51e-14 Iron status biomarkers; CRC cis rs4713118 0.869 rs9461405 chr6:27719375 G/T cg12273811 chr6:28175739 NA 0.53 7.6 0.39 3.1400000000000003e-13 Parkinson's disease; CRC cis rs6500602 0.819 rs3747580 chr16:4455675 G/A cg14951292 chr16:4525986 HMOX2;NMRAL1 0.65 8.35 0.42 1.91e-15 Schizophrenia; CRC cis rs7683537 0.887 rs7678412 chr4:185648611 T/C cg04058563 chr4:185651563 MLF1IP 0.72 9.11 0.45 8.52e-18 Systemic lupus erythematosus; CRC cis rs9915657 0.660 rs975772 chr17:70067810 T/G cg09344028 chr17:70110421 NA 0.49 7.33 0.37 1.77e-12 Thyroid hormone levels; CRC trans rs10090774 0.760 rs10111852 chr8:141937541 A/G cg14360659 chr9:137029702 RNU6ATAC -0.45 -6.16 -0.32 2.11e-9 Acute graft versus host disease in bone marrow transplantation (recipient effect); CRC cis rs1552244 1.000 rs6807846 chr3:10134491 G/T cg02579736 chr3:10068473 FANCD2;CIDECP 0.97 13.27 0.59 1.76e-32 Alzheimer's disease; CRC cis rs17666538 0.792 rs7820788 chr8:601846 C/T cg07234876 chr8:600039 NA 1.0 9.43 0.46 7.42e-19 IgG glycosylation; CRC cis rs736408 0.609 rs13087772 chr3:52782274 T/G cg07507251 chr3:52567010 NT5DC2 0.45 6.39 0.33 5.82e-10 Bipolar disorder; CRC cis rs10751667 0.643 rs7396046 chr11:937176 T/C cg01483505 chr11:975446 AP2A2 0.44 7.24 0.37 3.16e-12 Alzheimer's disease (late onset); CRC cis rs270601 0.837 rs367805 chr5:131701279 T/C cg04518342 chr5:131593106 PDLIM4 0.41 6.73 0.35 7.36e-11 Acylcarnitine levels; CRC cis rs6062302 0.522 rs4809312 chr20:62234240 C/T cg09650180 chr20:62225654 GMEB2 -0.5 -6.46 -0.34 3.84e-10 Glioblastoma; CRC cis rs977987 0.806 rs4888416 chr16:75449176 C/G cg03315344 chr16:75512273 CHST6 0.54 9.08 0.45 1.04e-17 Dupuytren's disease; CRC cis rs9640161 0.789 rs1464751 chr7:150021282 C/T cg13722127 chr7:150037890 RARRES2 0.48 7.56 0.38 4.04e-13 Blood protein levels;Circulating chemerin levels; CRC cis rs823143 0.570 rs823082 chr1:205786935 C/T cg24503407 chr1:205819492 PM20D1 -0.68 -10.66 -0.51 5.48e-23 Monocyte percentage of white cells; CRC trans rs2243480 1.000 rs160634 chr7:65528664 C/T cg10756647 chr7:56101905 PSPH -0.6 -7.11 -0.36 7.4e-12 Diabetic kidney disease; CRC cis rs2243480 1.000 rs316304 chr7:65616894 T/C cg18252515 chr7:66147081 NA -1.23 -14.38 -0.62 9.77e-37 Diabetic kidney disease; CRC cis rs72615157 0.634 rs7789890 chr7:99800559 G/T cg13153964 chr7:100026424 MEPCE;ZCWPW1 0.78 9.46 0.46 5.95e-19 Lung function (FEV1/FVC); CRC cis rs3617 0.572 rs2245538 chr3:52852060 T/C cg18099408 chr3:52552593 STAB1 -0.35 -6.0 -0.31 5.34e-9 Red blood cell count;Autism spectrum disorder or schizophrenia; CRC trans rs3960554 0.808 rs78587454 chr7:75688672 G/A cg19862616 chr7:65841803 NCRNA00174 0.74 8.67 0.43 1.99e-16 Eotaxin levels; CRC cis rs9488822 0.597 rs12214881 chr6:116342187 G/T cg15226275 chr6:116381976 FRK 0.3 8.45 0.42 9.45e-16 Cholesterol, total;LDL cholesterol; CRC trans rs12495832 0.778 rs77639470 chr3:147903892 G/A cg10221266 chr7:153579447 NA 0.55 6.06 0.32 3.81e-9 Chin dimples; CRC cis rs7662987 0.517 rs2851260 chr4:100033574 C/T cg12011299 chr4:100065546 ADH4 0.49 9.26 0.45 2.63e-18 Smoking initiation; CRC cis rs2836950 0.509 rs11088466 chr21:40580017 T/A cg11890956 chr21:40555474 PSMG1 -0.64 -9.49 -0.46 4.81e-19 Menarche (age at onset); CRC cis rs7103648 0.669 rs10437655 chr11:47391948 G/A cg20307385 chr11:47447363 PSMC3 0.93 16.45 0.67 8.26e-45 Diastolic blood pressure;Systolic blood pressure; CRC cis rs6460942 0.908 rs78780802 chr7:12233216 T/C cg06484146 chr7:12443880 VWDE -0.58 -6.05 -0.32 4.03e-9 Coronary artery disease; CRC trans rs2243480 1.000 rs464895 chr7:65527106 A/G cg10756647 chr7:56101905 PSPH 0.75 7.45 0.38 8.5e-13 Diabetic kidney disease; CRC cis rs5769707 0.967 rs2051626 chr22:50008973 G/A cg10356904 chr22:49881777 NA -0.32 -6.02 -0.32 4.59e-9 Monocyte count;Monocyte percentage of white cells; CRC cis rs9911578 1.000 rs12453459 chr17:56624291 C/T cg05425664 chr17:57184151 TRIM37 0.51 8.17 0.41 6.81e-15 Intelligence (multi-trait analysis); CRC cis rs7568458 0.684 rs1048740 chr2:85764966 A/T cg02493740 chr2:85810744 VAMP5 -0.54 -8.23 -0.41 4.52e-15 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); CRC trans rs1728785 1.000 rs3203684 chr16:68600440 C/T cg04657470 chr2:198365150 HSPE1;HSPD1 -0.6 -7.22 -0.37 3.64e-12 Ulcerative colitis; CRC cis rs873946 0.590 rs7071777 chr10:134559976 T/A cg27286337 chr10:134555280 INPP5A 0.79 9.64 0.47 1.55e-19 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CRC cis rs1045714 0.895 rs4721867 chr7:2643352 A/G cg24848437 chr7:2645542 IQCE -0.54 -5.82 -0.31 1.39e-8 Urate levels in lean individuals; CRC cis rs853679 0.517 rs4713148 chr6:28115921 G/A cg12172441 chr6:28176163 NA 0.64 7.53 0.38 5.03e-13 Depression; CRC cis rs17376456 0.825 rs10056879 chr5:93282218 C/A cg25358565 chr5:93447407 FAM172A 1.1 10.2 0.49 2.13e-21 Diabetic retinopathy; CRC cis rs597539 0.580 rs7935851 chr11:68731122 A/G cg06112835 chr11:68658793 MRPL21 0.39 6.16 0.32 2.15e-9 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC trans rs17685 0.753 rs9691174 chr7:75790405 T/C cg19862616 chr7:65841803 NCRNA00174 0.97 16.87 0.68 1.91e-46 Coffee consumption;Coffee consumption (cups per day); CRC cis rs7615952 0.641 rs12488180 chr3:125782236 C/T cg02772935 chr3:125709198 NA -0.48 -5.69 -0.3 2.82e-8 Blood pressure (smoking interaction); CRC cis rs2075371 0.674 rs11771785 chr7:134013249 A/G cg02659138 chr7:134003124 SLC35B4 -0.36 -5.95 -0.31 6.82e-9 Mean platelet volume; CRC cis rs1163251 0.902 rs483360 chr1:120200606 C/T cg19096424 chr1:120255104 PHGDH -0.45 -6.31 -0.33 9.03e-10 Blood metabolite levels; CRC cis rs6540556 0.723 rs6540551 chr1:209925295 C/T cg23920097 chr1:209922102 NA -0.54 -6.65 -0.34 1.22e-10 Red blood cell count; CRC trans rs208520 0.690 rs207114 chr6:66791703 C/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.09 -14.79 -0.63 2.74e-38 Exhaled nitric oxide output; CRC cis rs1552244 0.572 rs68121641 chr3:10165845 T/A cg02579736 chr3:10068473 FANCD2;CIDECP 1.01 11.58 0.54 2.98e-26 Alzheimer's disease; CRC cis rs12950390 0.853 rs67441169 chr17:45854462 T/G cg24803719 chr17:45855879 NA -0.32 -7.02 -0.36 1.24e-11 IgG glycosylation; CRC cis rs12971120 1.000 rs12971120 chr18:72174023 A/G cg26446133 chr18:72167187 CNDP2 -0.78 -12.19 -0.56 1.82e-28 Refractive error; CRC cis rs6500602 0.674 rs8051695 chr16:4536621 T/C cg06139259 chr16:4526053 HMOX2;NMRAL1 0.5 6.77 0.35 5.79e-11 Schizophrenia; CRC trans rs10504229 1.000 rs73609760 chr8:58192170 A/G cg04077850 chr5:125800366 GRAMD3 0.38 6.24 0.33 1.33e-9 Developmental language disorder (linguistic errors); CRC cis rs4481887 0.708 rs6688853 chr1:248548006 G/A cg00666640 chr1:248458726 OR2T12 0.41 7.46 0.38 7.72e-13 Common traits (Other); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg26034150 chr2:201936608 FAM126B;NDUFB3 0.41 6.01 0.31 4.79e-9 Intelligence (multi-trait analysis); CRC cis rs7647973 1.000 rs12583 chr3:49571462 G/T cg20833759 chr3:49053208 WDR6;DALRD3 -0.55 -8.05 -0.41 1.5e-14 Menarche (age at onset); CRC cis rs9818758 0.607 rs73084135 chr3:49272218 A/G cg07636037 chr3:49044803 WDR6 -0.85 -6.46 -0.34 3.81e-10 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; CRC cis rs7614311 0.731 rs73117087 chr3:63948696 A/G cg22134162 chr3:63841271 THOC7 -0.57 -5.83 -0.31 1.3e-8 Lung function (FVC);Lung function (FEV1); CRC cis rs3733585 0.673 rs4467563 chr4:9953460 A/T cg11266682 chr4:10021025 SLC2A9 -0.47 -9.62 -0.47 1.76e-19 Cleft plate (environmental tobacco smoke interaction); CRC cis rs6952808 0.594 rs3778965 chr7:2138296 G/A cg21782813 chr7:2030301 MAD1L1 0.54 9.45 0.46 6.57e-19 Bipolar disorder and schizophrenia; CRC cis rs9926296 0.715 rs467035 chr16:89740285 C/G cg03605463 chr16:89740564 NA -0.57 -8.76 -0.43 1.07e-16 Vitiligo; CRC cis rs4332037 0.539 rs62444881 chr7:2052318 C/T cg02825527 chr7:2087843 MAD1L1 -0.5 -5.91 -0.31 8.66e-9 Bipolar disorder; CRC cis rs7927771 1.000 rs11605774 chr11:47832793 G/A cg05585544 chr11:47624801 NA -0.62 -10.84 -0.51 1.34e-23 Subjective well-being; CRC cis rs9894429 0.789 rs7502346 chr17:79603741 T/C cg18240062 chr17:79603768 NPLOC4 0.66 11.84 0.55 3.51e-27 Eye color traits; CRC cis rs898097 0.801 rs68141193 chr17:80878816 C/T cg15369054 chr17:80825471 TBCD 0.55 8.84 0.44 5.93e-17 Breast cancer; CRC cis rs7826238 0.509 rs2948288 chr8:8115304 A/G cg08975724 chr8:8085496 FLJ10661 0.48 7.29 0.37 2.34e-12 Systolic blood pressure; CRC cis rs8060686 0.920 rs73594581 chr16:67955554 G/A cg08314208 chr16:67682810 RLTPR -0.66 -7.43 -0.38 9.64e-13 HDL cholesterol;Metabolic syndrome; CRC cis rs4474465 0.688 rs4277140 chr11:78285096 G/T cg27205649 chr11:78285834 NARS2 -0.51 -6.55 -0.34 2.18e-10 Alzheimer's disease (survival time); CRC cis rs11785400 0.793 rs4430070 chr8:143729184 G/C cg10596483 chr8:143751796 JRK 0.48 6.48 0.34 3.4e-10 Schizophrenia; CRC cis rs1048238 0.506 rs698889 chr1:16267040 A/C cg21385522 chr1:16154831 NA -0.63 -8.98 -0.44 2.15e-17 Systolic blood pressure; CRC cis rs10946940 0.965 rs10946935 chr6:27501345 T/C cg21251018 chr6:28226885 NKAPL -0.41 -6.33 -0.33 7.81e-10 Systemic lupus erythematosus; CRC trans rs2243480 1.000 rs458291 chr7:65520479 C/A cg10756647 chr7:56101905 PSPH 0.76 7.74 0.39 1.2e-13 Diabetic kidney disease; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg13099106 chr12:120525172 CCDC64 0.51 6.91 0.36 2.49e-11 Thyroid stimulating hormone; CRC cis rs57561814 0.655 rs8180726 chr7:22749306 A/C cg26061582 chr7:22766209 IL6 0.73 6.27 0.33 1.17e-9 Tonsillectomy; CRC cis rs35146811 0.735 rs11767968 chr7:99790971 G/A cg13334819 chr7:99746414 C7orf59 -0.51 -6.72 -0.35 7.79e-11 Coronary artery disease; CRC cis rs1799949 1.000 rs12951869 chr17:41187567 T/G cg19454999 chr17:41278357 BRCA1;NBR2 0.53 7.99 0.4 2.31e-14 Menopause (age at onset); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg22985785 chr1:22352096 HSPC157 0.42 6.27 0.33 1.13e-9 Intelligence (multi-trait analysis); CRC cis rs2235649 0.789 rs4567715 chr16:1849363 G/C cg00935504 chr16:1863053 HAGH 0.31 5.65 0.3 3.39e-8 Blood metabolite levels; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg16253168 chr6:13614902 NOL7 0.46 6.56 0.34 2.09e-10 Response to antipsychotic treatment; CRC cis rs7726839 0.574 rs12517345 chr5:628294 G/A cg16447950 chr5:562315 NA -0.74 -9.76 -0.47 6.14e-20 Obesity-related traits; CRC cis rs6459804 1.000 rs58278053 chr7:157512934 A/T cg03339717 chr7:157503488 PTPRN2 0.34 5.91 0.31 8.33e-9 Bipolar disorder and schizophrenia; CRC cis rs7705042 0.826 rs11749731 chr5:141500436 A/C cg07392085 chr5:141489673 NDFIP1 0.47 7.44 0.38 8.94e-13 Asthma; CRC cis rs7737355 0.947 rs12656936 chr5:130788642 A/C cg06307176 chr5:131281290 NA -0.43 -6.43 -0.33 4.55e-10 Life satisfaction; CRC cis rs6952808 0.609 rs11772205 chr7:1951236 C/T cg04267008 chr7:1944627 MAD1L1 -0.62 -9.58 -0.47 2.39e-19 Bipolar disorder and schizophrenia; CRC cis rs7927771 0.965 rs35184771 chr11:47475189 G/T cg05585544 chr11:47624801 NA -0.62 -11.26 -0.53 4.14e-25 Subjective well-being; CRC cis rs1552244 0.608 rs7615408 chr3:10000186 A/G cg16606324 chr3:10149918 C3orf24 0.48 7.33 0.37 1.78e-12 Alzheimer's disease; CRC cis rs1552244 0.832 rs67145301 chr3:10197314 G/A cg02579736 chr3:10068473 FANCD2;CIDECP 1.02 11.43 0.53 1.07e-25 Alzheimer's disease; CRC cis rs6952808 0.636 rs73048162 chr7:1949328 T/C cg21782813 chr7:2030301 MAD1L1 0.4 7.24 0.37 3.22e-12 Bipolar disorder and schizophrenia; CRC cis rs7959452 0.590 rs28778648 chr12:69771911 C/A cg14784868 chr12:69753453 YEATS4 0.82 14.27 0.62 2.67e-36 Blood protein levels; CRC cis rs72945132 0.882 rs72949078 chr11:70217708 T/C cg00319359 chr11:70116639 PPFIA1 0.65 6.89 0.36 2.78e-11 Coronary artery disease; CRC cis rs2979489 0.945 rs17627903 chr8:30351812 T/C cg26383811 chr8:30366931 RBPMS -0.71 -9.78 -0.47 5.31e-20 Mean corpuscular hemoglobin;Plateletcrit;Neutrophil count;Granulocyte count;Sum basophil neutrophil counts;Mean corpuscular volume;Myeloid white cell count;Sum neutrophil eosinophil counts; CRC cis rs9811920 0.609 rs2452320 chr3:99645216 G/A cg07805332 chr3:99536008 MIR548G;C3orf26 -0.51 -7.68 -0.39 1.84e-13 Axial length; CRC cis rs748404 0.631 rs3809482 chr15:43661802 T/C cg02155558 chr15:43621948 ADAL;LCMT2 0.53 7.67 0.39 1.98e-13 Lung cancer; CRC cis rs4664293 0.867 rs2081722 chr2:160594208 A/T cg08347373 chr2:160653686 CD302 -0.47 -7.43 -0.38 9.32e-13 Monocyte percentage of white cells; CRC cis rs7772486 0.846 rs2748499 chr6:146315002 T/C cg13319975 chr6:146136371 FBXO30 -0.38 -5.6 -0.3 4.48e-8 Lobe attachment (rater-scored or self-reported); CRC cis rs1799949 1.000 rs34534709 chr17:41302940 C/G cg05368731 chr17:41323189 NBR1 0.65 9.59 0.47 2.27e-19 Menopause (age at onset); CRC cis rs644799 1.000 rs1944074 chr11:95511445 C/A cg03916912 chr11:95522834 CEP57;FAM76B 0.96 18.02 0.7 5.41e-51 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg00116463 chr17:19266443 B9D1 0.38 6.21 0.32 1.64e-9 Liver disease severity in Alagille syndrome; CRC trans rs11098499 0.954 rs10017371 chr4:120293776 A/G cg25214090 chr10:38739885 LOC399744 0.61 9.6 0.47 2.18e-19 Corneal astigmatism; CRC trans rs10983614 1.000 rs7867776 chr9:120072627 A/G cg07442639 chr11:3014225 NAP1L4 0.46 6.3 0.33 9.29e-10 Survival in pancreatic cancer; CRC cis rs2303759 0.626 rs12982246 chr19:49801169 A/G cg22590775 chr19:49891494 CCDC155 0.57 7.55 0.38 4.21e-13 Multiple sclerosis; CRC cis rs73198271 0.563 rs3748143 chr8:8655237 A/G cg01851573 chr8:8652454 MFHAS1 -0.58 -7.39 -0.38 1.21e-12 Bone ultrasound measurement (broadband ultrasound attenuation); CRC cis rs4713118 0.955 rs9368528 chr6:27683798 G/A cg20933634 chr6:27740509 NA 0.57 8.08 0.41 1.24e-14 Parkinson's disease; CRC cis rs6570726 0.935 rs428659 chr6:145827039 T/C cg23711669 chr6:146136114 FBXO30 0.68 12.16 0.56 2.33e-28 Lobe attachment (rater-scored or self-reported); CRC cis rs9814567 0.752 rs4634170 chr3:134335471 T/C cg06109529 chr3:134205091 CEP63;ANAPC13 -0.68 -9.74 -0.47 7.1e-20 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs60871478 1.000 rs4397290 chr7:828493 T/C cg13844804 chr7:814759 HEATR2 -0.65 -8.35 -0.42 1.87e-15 Cerebrospinal P-tau181p levels; CRC cis rs9462027 0.651 rs4259246 chr6:34803947 C/T cg07306190 chr6:34760872 UHRF1BP1 -0.33 -5.72 -0.3 2.34e-8 Systemic lupus erythematosus; CRC cis rs11690935 0.959 rs10204502 chr2:172588866 C/G cg13550731 chr2:172543902 DYNC1I2 -1.1 -18.59 -0.72 3.14e-53 Schizophrenia; CRC cis rs10256972 0.681 rs12702016 chr7:1129392 C/T cg22907277 chr7:1156413 C7orf50 0.68 10.43 0.5 3.34e-22 Longevity;Endometriosis; CRC cis rs9549260 0.739 rs7330614 chr13:41199421 G/A cg21288729 chr13:41239152 FOXO1 0.44 6.97 0.36 1.75e-11 Red blood cell count; CRC cis rs57221529 0.766 rs72703070 chr5:590458 T/C cg17948913 chr5:572064 NA 0.52 5.95 0.31 6.79e-9 Lung disease severity in cystic fibrosis; CRC cis rs2228479 0.850 rs1800355 chr16:89813194 C/T cg06558623 chr16:89946397 TCF25 1.15 10.8 0.51 1.85e-23 Skin colour saturation; CRC trans rs2243480 1.000 rs4718309 chr7:65627764 G/C cg10756647 chr7:56101905 PSPH -0.76 -7.89 -0.4 4.47e-14 Diabetic kidney disease; CRC cis rs1552244 0.882 rs17081288 chr3:10042113 A/G cg10729496 chr3:10149963 C3orf24 0.5 6.53 0.34 2.55e-10 Alzheimer's disease; CRC cis rs28489187 0.706 rs233074 chr1:85809065 T/C cg17737388 chr1:85724454 C1orf52 0.37 5.6 0.3 4.46e-8 Asymmetrical dimethylarginine levels;Serum dimethylarginine levels (asymmetric/symetric ratio); CRC cis rs950776 0.518 rs11630349 chr15:78824608 C/T cg06917634 chr15:78832804 PSMA4 0.66 10.42 0.5 3.55e-22 Sudden cardiac arrest; CRC cis rs10256972 0.758 rs2280724 chr7:1064720 A/G cg03923535 chr7:1197113 ZFAND2A 0.48 6.65 0.34 1.22e-10 Longevity;Endometriosis; CRC cis rs9914988 1.000 rs901975 chr17:27189774 A/G cg20469991 chr17:27169893 C17orf63 0.47 5.91 0.31 8.55e-9 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs644799 0.542 rs10831416 chr11:95467220 A/G cg25622487 chr11:95524042 FAM76B;CEP57 0.49 6.87 0.35 3.18e-11 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs7666738 0.830 rs7659006 chr4:98934529 T/C cg05340658 chr4:99064831 C4orf37 0.6 9.35 0.46 1.41e-18 Colonoscopy-negative controls vs population controls; CRC cis rs6964587 0.967 rs1978061 chr7:91779242 G/A cg17063962 chr7:91808500 NA 0.84 14.85 0.63 1.52e-38 Breast cancer; CRC cis rs12477438 0.798 rs17708218 chr2:99696284 C/A cg26064155 chr2:99771622 LIPT1;TSGA10 -0.79 -11.21 -0.53 6.35e-25 Chronic sinus infection; CRC cis rs2721195 0.549 rs2958492 chr8:145919126 C/T cg10700019 chr8:145984882 NA -0.29 -5.79 -0.3 1.67e-8 Age at first birth; CRC cis rs9891119 0.965 rs7217655 chr17:40496024 C/T cg06270615 chr17:40516068 STAT3 -0.27 -5.97 -0.31 6.21e-9 Multiple sclerosis;Crohn's disease; CRC trans rs4689592 0.503 rs3857180 chr4:7073899 T/G cg07817883 chr1:32538562 TMEM39B 0.62 6.77 0.35 6e-11 Monocyte percentage of white cells; CRC cis rs10206020 0.842 rs7590900 chr2:1574902 A/G cg26248373 chr2:1572462 NA -0.83 -12.38 -0.56 3.62e-29 IgG glycosylation; CRC cis rs9399135 0.838 rs4896126 chr6:135342786 C/A cg22676075 chr6:135203613 NA 0.4 6.25 0.33 1.27e-9 Red blood cell count; CRC cis rs3093024 0.874 rs3093018 chr6:167539805 C/T cg19688584 chr6:167529678 CCR6 -0.33 -6.15 -0.32 2.28e-9 Rheumatoid arthritis; CRC cis rs10750766 1 rs10750766 chr11:65473798 C/A cg08755490 chr11:65554678 OVOL1 0.53 6.79 0.35 5.13e-11 High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count;Immature fraction of reticulocytes; CRC cis rs780096 0.506 rs1647285 chr2:27714511 A/C cg12648201 chr2:27665141 KRTCAP3 -0.33 -6.66 -0.34 1.15e-10 Total body bone mineral density; CRC cis rs9462027 0.539 rs2814963 chr6:34708908 C/T cg07306190 chr6:34760872 UHRF1BP1 -0.34 -6.12 -0.32 2.72e-9 Systemic lupus erythematosus; CRC cis rs798554 0.704 rs798503 chr7:2789704 G/A cg13628971 chr7:2884303 GNA12 0.42 6.58 0.34 1.85e-10 Height; CRC trans rs875971 0.660 rs2191268 chr7:66110224 C/T cg24494008 chr3:160116838 IFT80;SMC4 -0.42 -6.32 -0.33 8.3e-10 Aortic root size; CRC cis rs9322193 0.923 rs35830138 chr6:149989771 T/C cg05861140 chr6:150128134 PCMT1 -0.36 -5.8 -0.3 1.52e-8 Lung cancer; CRC cis rs3858526 0.727 rs10769353 chr11:5954809 C/T cg13902645 chr11:5959945 NA 0.75 12.22 0.56 1.46e-28 DNA methylation (variation); CRC cis rs929354 0.772 rs6459737 chr7:156975136 G/A cg16102536 chr7:156981717 UBE3C 0.4 6.76 0.35 6.39e-11 Body mass index; CRC cis rs9858542 0.953 rs9858280 chr3:49597737 T/C cg00383909 chr3:49044727 WDR6 0.44 5.64 0.3 3.76e-8 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs1008375 1.000 rs11947857 chr4:17691047 T/C cg16339924 chr4:17578868 LAP3 -0.47 -5.91 -0.31 8.62e-9 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs73206853 0.925 rs12310834 chr12:110762756 A/G cg12870014 chr12:110450643 ANKRD13A 0.66 8.28 0.42 3.22e-15 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC cis rs9322193 0.923 rs57012784 chr6:149948827 G/A cg00933542 chr6:150070202 PCMT1 0.29 6.07 0.32 3.54e-9 Lung cancer; CRC cis rs7927592 0.913 rs6591340 chr11:68297636 A/G cg01657329 chr11:68192670 LRP5 -0.46 -6.56 -0.34 2.06e-10 Total body bone mineral density; CRC cis rs1023500 0.573 rs13057094 chr22:42470317 T/C cg04733989 chr22:42467013 NAGA 0.61 9.0 0.44 1.84e-17 Schizophrenia; CRC cis rs4731207 0.671 rs4397336 chr7:124503196 C/T cg23710748 chr7:124431027 NA 0.38 5.75 0.3 2.08e-8 Cutaneous malignant melanoma; CRC cis rs2239547 0.523 rs6803486 chr3:53098209 T/A cg18404041 chr3:52824283 ITIH1 -0.34 -6.03 -0.32 4.29e-9 Schizophrenia; CRC trans rs703108 0.731 rs7898954 chr10:22323646 A/G cg18002905 chr4:8442565 ACOX3 -0.51 -6.0 -0.31 5.23e-9 Monocyte percentage of white cells; CRC cis rs4731207 0.596 rs12537473 chr7:124586711 G/A cg23710748 chr7:124431027 NA -0.38 -6.08 -0.32 3.35e-9 Cutaneous malignant melanoma; CRC cis rs7618915 0.501 rs2159644 chr3:52774530 C/T cg10802521 chr3:52805072 NEK4 -0.57 -8.87 -0.44 4.63e-17 Bipolar disorder; CRC cis rs9398803 0.830 rs1490387 chr6:126834083 C/A cg19875578 chr6:126661172 C6orf173 0.42 5.86 0.31 1.15e-8 Male-pattern baldness; CRC cis rs9910055 0.529 rs228757 chr17:42164885 G/C cg13607699 chr17:42295918 UBTF -0.49 -6.26 -0.33 1.17e-9 Total body bone mineral density; CRC cis rs12692738 0.526 rs355862 chr2:165630100 A/G cg03182029 chr2:165697222 COBLL1 0.5 5.86 0.31 1.11e-8 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);Waist-to-hip ratio adjusted for BMI in non-smokers;Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction);Waist-to-hip ratio adjusted for body mass index; CRC cis rs3749237 1.000 rs11130214 chr3:49735746 C/G cg05072774 chr3:49840536 C3orf54 0.43 5.87 0.31 1.08e-8 Resting heart rate; CRC cis rs968567 1.000 rs968567 chr11:61595564 C/T cg07005513 chr11:61595956 FADS2 -0.47 -5.8 -0.3 1.57e-8 Blood metabolite levels;Rheumatoid arthritis;Vitiligo;Glycerophospholipid levels; CRC cis rs7224610 0.966 rs3794748 chr17:53365172 A/G cg02383154 chr17:53343283 HLF -0.33 -5.85 -0.31 1.16e-8 Urate levels; CRC cis rs9583531 0.600 rs7984468 chr13:111362093 C/A cg24331049 chr13:111365604 ING1 0.57 7.92 0.4 3.6e-14 Coronary artery disease; CRC cis rs1707322 0.721 rs4330955 chr1:46217485 G/C cg03146154 chr1:46216737 IPP 0.68 9.94 0.48 1.59e-20 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs968567 0.906 rs61897793 chr11:61599347 G/A cg16576620 chr11:61596068 FADS2 -0.47 -5.78 -0.3 1.72e-8 Blood metabolite levels;Rheumatoid arthritis;Vitiligo;Glycerophospholipid levels; CRC cis rs6968419 0.714 rs17138472 chr7:115892738 A/G cg02561103 chr7:115862891 TES -0.42 -6.43 -0.33 4.55e-10 Intraocular pressure; CRC cis rs883565 0.740 rs6599006 chr3:39114276 T/G cg01426195 chr3:39028469 NA -0.54 -8.68 -0.43 1.86e-16 Handedness; CRC cis rs921968 0.541 rs526897 chr2:219433597 C/T cg02176678 chr2:219576539 TTLL4 0.54 8.52 0.43 5.84e-16 Mean corpuscular hemoglobin concentration; CRC cis rs9733 0.596 rs72702557 chr1:150680130 A/G cg15448220 chr1:150897856 SETDB1 0.45 6.41 0.33 5.09e-10 Tonsillectomy; CRC cis rs7618501 0.633 rs6772095 chr3:49978069 C/T cg24308560 chr3:49941425 MST1R -0.51 -8.26 -0.41 3.52e-15 Intelligence (multi-trait analysis); CRC cis rs2242116 0.796 rs2290546 chr3:46965197 C/G cg02527881 chr3:46936655 PTH1R -0.48 -8.35 -0.42 1.93e-15 Birth weight; CRC cis rs3751196 0.708 rs12425537 chr12:104151931 T/C cg02344784 chr12:104178138 NT5DC3 0.65 5.82 0.31 1.41e-8 Sense of smell; CRC cis rs11161851 0.839 rs12120668 chr1:75321017 G/C cg11196437 chr1:75593865 LHX8 -0.28 -5.71 -0.3 2.5e-8 Visceral fat; CRC cis rs6860806 0.507 rs272880 chr5:131670178 C/T cg22638593 chr5:131593259 PDLIM4 0.38 6.32 0.33 8.31e-10 Breast cancer; CRC cis rs3760982 0.967 rs3760984 chr19:44286762 C/T cg21496419 chr19:44306685 LYPD5 0.34 6.42 0.33 4.66e-10 Breast cancer (estrogen-receptor negative);Breast cancer; CRC cis rs2304069 0.545 rs1864998 chr5:149389465 C/T cg22760475 chr5:149380129 HMGXB3;TIGD6 0.46 6.72 0.35 8.25e-11 HIV-1 control; CRC cis rs7082209 0.941 rs67379075 chr10:44811968 A/C cg09554077 chr10:44749378 NA 0.44 5.87 0.31 1.04e-8 Resistance to Mycobacterium tuberculosis in HIV-positive individuals measured by a negative tuberculin skin test (continuous); CRC cis rs8072100 0.902 rs12051716 chr17:45582395 G/A cg08085267 chr17:45401833 C17orf57 0.66 10.82 0.51 1.49e-23 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs1941023 0.567 rs955019 chr11:60174250 C/T cg08716584 chr11:60157161 MS4A7 -0.44 -7.34 -0.38 1.68e-12 Congenital heart disease (maternal effect); CRC cis rs6598955 0.724 rs12726972 chr1:26639634 A/G cg00852783 chr1:26633632 UBXN11 -0.4 -6.58 -0.34 1.83e-10 Obesity-related traits; CRC cis rs172166 0.694 rs188105 chr6:28071393 C/T cg21251018 chr6:28226885 NKAPL 0.47 7.26 0.37 2.83e-12 Cardiac Troponin-T levels; CRC cis rs6570726 0.755 rs2103633 chr6:145894021 C/T cg05347473 chr6:146136440 FBXO30 0.38 5.85 0.31 1.18e-8 Lobe attachment (rater-scored or self-reported); CRC cis rs10463316 0.862 rs11747047 chr5:150777953 C/T cg03212797 chr5:150827313 SLC36A1 -0.53 -8.42 -0.42 1.14e-15 Metabolite levels (Pyroglutamine); CRC cis rs77972916 0.505 rs6719754 chr2:43526386 A/T cg06169590 chr2:43455088 ZFP36L2;LOC100129726 -0.65 -7.78 -0.39 9.33e-14 Granulocyte percentage of myeloid white cells; CRC cis rs6750795 0.765 rs6742387 chr2:232354832 G/T cg21424120 chr2:232395308 NMUR1 0.28 5.68 0.3 3.03e-8 Height; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg18089145 chr14:39572493 SEC23A 0.41 6.07 0.32 3.58e-9 Intelligence (multi-trait analysis); CRC cis rs7781557 0.938 rs73192015 chr7:102511732 C/T cg18108683 chr7:102477205 FBXL13 -0.49 -6.44 -0.33 4.12e-10 Colorectal adenoma (advanced); CRC cis rs11628318 0.614 rs62007936 chr14:103198740 G/A cg08075719 chr14:103021372 NA 0.63 7.03 0.36 1.23e-11 Platelet count; CRC cis rs1862618 0.853 rs832554 chr5:56115036 A/G cg24531977 chr5:56204891 C5orf35 -0.81 -10.88 -0.51 9.16e-24 Initial pursuit acceleration; CRC cis rs6951245 0.580 rs77101766 chr7:1122438 A/G cg18402987 chr7:1209562 NA 0.56 6.71 0.35 8.47e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs5753618 0.561 rs13054220 chr22:31704492 A/G cg07713946 chr22:31675144 LIMK2 0.39 5.67 0.3 3.14e-8 Colorectal cancer; CRC cis rs12594515 1.000 rs6493169 chr15:45986994 A/G cg19682013 chr15:45996608 NA -0.3 -6.26 -0.33 1.2e-9 Waist circumference;Weight; CRC cis rs7772486 0.754 rs10872580 chr6:146140281 C/T cg05347473 chr6:146136440 FBXO30 -0.39 -5.99 -0.31 5.52e-9 Lobe attachment (rater-scored or self-reported); CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg06231882 chr16:81040594 CENPN;C16orf61 0.56 7.41 0.38 1.06e-12 Thyroid stimulating hormone; CRC cis rs7824557 0.527 rs2736296 chr8:11234844 G/A cg20542592 chr8:11973495 FAM66D 0.32 5.63 0.3 3.82e-8 Retinal vascular caliber; CRC cis rs11190604 1.000 rs10883502 chr10:102238343 T/G cg16342193 chr10:102329863 NA -0.36 -5.86 -0.31 1.14e-8 Palmitoleic acid (16:1n-7) levels; CRC cis rs8067545 0.611 rs757494 chr17:20150340 C/T cg13482628 chr17:19912719 NA -0.47 -7.46 -0.38 7.67e-13 Schizophrenia; CRC cis rs9659323 1.000 rs9658899 chr1:119504543 G/A cg26570165 chr1:119541833 NA -0.38 -6.46 -0.34 3.67e-10 Body mass index; CRC cis rs2882667 0.861 rs10075541 chr5:138390318 C/T cg09476006 chr5:138032270 NA 0.43 7.26 0.37 2.89e-12 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs2304069 0.545 rs7445660 chr5:149413610 A/C cg12661370 chr5:149340060 SLC26A2 0.43 6.2 0.32 1.67e-9 HIV-1 control; CRC cis rs2179367 0.920 rs638407 chr6:149738350 A/G cg11245181 chr6:149772854 ZC3H12D -0.41 -6.16 -0.32 2.08e-9 Dupuytren's disease; CRC cis rs11122272 0.735 rs2739518 chr1:231537633 C/T cg06096015 chr1:231504339 EGLN1 0.41 6.18 0.32 1.89e-9 Hemoglobin concentration; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg17272331 chr6:101328506 ASCC3 0.47 6.29 0.33 1.03e-9 Thyroid stimulating hormone; CRC cis rs2295359 0.892 rs72676058 chr1:67627681 C/A cg17031739 chr1:67600172 NA 0.45 7.04 0.36 1.12e-11 Psoriasis; CRC cis rs826838 1.000 rs10880914 chr12:38720543 C/T cg26384229 chr12:38710491 ALG10B 0.76 10.85 0.51 1.21e-23 Heart rate; CRC cis rs34779708 0.966 rs113170867 chr10:35450147 C/T cg03585969 chr10:35415529 CREM 0.66 8.75 0.43 1.14e-16 Inflammatory bowel disease;Crohn's disease; CRC cis rs4722166 0.630 rs4722168 chr7:22779002 G/A cg05472934 chr7:22766657 IL6 0.76 12.37 0.56 4.12e-29 Lung cancer; CRC trans rs3806843 0.900 rs2563286 chr5:140125199 T/A cg06840491 chr10:48416966 GDF2 -0.34 -5.99 -0.31 5.54e-9 Depressive symptoms (multi-trait analysis); CRC cis rs763014 0.932 rs35067229 chr16:649638 T/C cg00908189 chr16:619842 PIGQ 0.69 11.59 0.54 2.89e-26 Height; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg02386183 chr20:13619553 TASP1 0.41 6.72 0.35 8.1e-11 Liver disease severity in Alagille syndrome; CRC cis rs6938 0.534 rs11636892 chr15:75266049 G/C cg17294928 chr15:75287854 SCAMP5 0.49 7.06 0.36 1.02e-11 Breast cancer; CRC cis rs12936587 0.748 rs12939297 chr17:17524247 G/A cg16928487 chr17:17741425 SREBF1 0.39 5.82 0.31 1.42e-8 Hip circumference;Coronary artery disease or large artery stroke;Coronary heart disease;Coronary artery disease; CRC cis rs2204008 0.715 rs11514282 chr12:38169056 G/T cg13010199 chr12:38710504 ALG10B 0.47 5.94 0.31 7.08e-9 Bladder cancer; CRC trans rs453301 0.571 rs2929453 chr8:9084341 A/G cg16141378 chr3:129829833 LOC729375 0.4 6.31 0.33 9.01e-10 Joint mobility (Beighton score); CRC cis rs10504229 0.683 rs903706 chr8:58128134 T/G cg04204079 chr8:58130323 NA -0.45 -5.78 -0.3 1.71e-8 Developmental language disorder (linguistic errors); CRC cis rs868036 1.000 rs4776975 chr15:68102220 G/C cg05925327 chr15:68127851 NA -0.31 -6.0 -0.31 5.18e-9 Restless legs syndrome; CRC cis rs7429990 0.930 rs7374516 chr3:48002640 T/C cg11946769 chr3:48343235 NME6 0.44 5.8 0.3 1.53e-8 Educational attainment (years of education); CRC cis rs11955398 0.501 rs10067618 chr5:60010995 G/A cg02684056 chr5:59996105 DEPDC1B -0.4 -5.82 -0.31 1.41e-8 Intelligence (multi-trait analysis); CRC cis rs763014 0.932 rs2384974 chr16:651279 C/G cg08989290 chr16:615782 NHLRC4 0.47 9.39 0.46 1.06e-18 Height; CRC cis rs28386778 0.830 rs2665841 chr17:61861219 A/T cg06873352 chr17:61820015 STRADA 0.8 15.29 0.64 2.98e-40 Prudent dietary pattern; CRC cis rs1862618 0.671 rs2591955 chr5:56244948 C/T cg03609598 chr5:56110824 MAP3K1 0.59 7.99 0.4 2.34e-14 Initial pursuit acceleration; CRC cis rs9649213 0.593 rs6465683 chr7:98026092 C/A cg24562669 chr7:97807699 LMTK2 0.44 7.29 0.37 2.3e-12 Prostate cancer (SNP x SNP interaction); CRC trans rs6703335 0.870 rs10803142 chr1:243598234 A/G cg16677162 chr22:22465502 NA 0.34 6.07 0.32 3.53e-9 Schizophrenia;Schizophrenia, schizoaffective disorder or bipolar disorder; CRC cis rs9515201 0.627 rs11838637 chr13:111029923 G/A cg06243866 chr13:111019493 COL4A2 -0.43 -6.72 -0.35 7.97e-11 White matter hyperintensity burden; CRC cis rs929354 0.713 rs3802130 chr7:156965237 A/G cg16102536 chr7:156981717 UBE3C 0.4 6.69 0.35 9.57e-11 Body mass index; CRC cis rs3026445 0.851 rs34840178 chr12:110832027 A/G cg12870014 chr12:110450643 ANKRD13A 0.37 5.79 0.3 1.66e-8 QT interval; CRC cis rs6459804 0.967 rs10233396 chr7:157512290 C/T cg05731713 chr7:157510257 PTPRN2 0.47 7.91 0.4 3.95e-14 Bipolar disorder and schizophrenia; CRC cis rs734999 0.588 rs3748817 chr1:2525665 T/C cg18854424 chr1:2615690 NA 0.5 9.88 0.48 2.55e-20 Ulcerative colitis; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg00941241 chr1:9885960 CLSTN1 0.38 6.2 0.32 1.73e-9 Response to antipsychotic treatment; CRC cis rs736408 0.812 rs9324 chr3:52825585 T/C cg11645453 chr3:52864694 ITIH4 0.47 8.38 0.42 1.55e-15 Bipolar disorder; CRC cis rs6866344 0.661 rs72812606 chr5:178129094 A/T cg10224037 chr5:178157518 ZNF354A 0.79 11.57 0.54 3.43e-26 Neutrophil percentage of white cells; CRC trans rs8002861 0.875 rs12428432 chr13:44464043 A/G cg17145862 chr1:211918768 LPGAT1 -0.71 -13.0 -0.58 1.87e-31 Leprosy; CRC cis rs4713118 0.513 rs149989 chr6:27998184 T/A cg12273811 chr6:28175739 NA 0.57 8.47 0.42 8.16e-16 Parkinson's disease; CRC cis rs7605827 0.897 rs4668908 chr2:15589290 G/T cg19274914 chr2:15703543 NA 0.37 5.72 0.3 2.4e-8 Educational attainment (years of education); CRC cis rs6952808 0.929 rs4721217 chr7:1973579 C/T cg22963979 chr7:1858916 MAD1L1 -0.54 -7.67 -0.39 1.95e-13 Bipolar disorder and schizophrenia; CRC cis rs7666738 0.830 rs13110903 chr4:98946373 A/G cg17366294 chr4:99064904 C4orf37 0.43 7.34 0.38 1.69e-12 Colonoscopy-negative controls vs population controls; CRC cis rs7615952 0.599 rs12485717 chr3:125707075 C/T cg18479299 chr3:125709523 NA 0.5 5.95 0.31 6.85e-9 Blood pressure (smoking interaction); CRC cis rs13082711 0.554 rs10514679 chr3:27412591 A/G cg02860705 chr3:27208620 NA 0.88 11.47 0.53 7.46e-26 Systolic blood pressure;Diastolic blood pressure;Blood pressure; CRC cis rs9355610 0.609 rs7772112 chr6:167408896 G/A cg23791538 chr6:167370224 RNASET2 0.52 7.09 0.36 8.49e-12 Graves' disease; CRC cis rs17345786 1.000 rs3804775 chr3:101306507 C/T cg11279151 chr3:101281821 RG9MTD1 -0.69 -8.98 -0.44 2.18e-17 Colonoscopy-negative controls vs population controls; CRC cis rs9905704 0.846 rs302851 chr17:56685424 G/A cg12560992 chr17:57184187 TRIM37 0.57 8.24 0.41 4.03e-15 Testicular germ cell tumor; CRC cis rs17253792 0.822 rs75560658 chr14:56079896 C/T cg24579896 chr14:56047964 C14orf33;KTN1 0.71 5.69 0.3 2.81e-8 Putamen volume; CRC trans rs6472235 0.837 rs4380924 chr8:66920744 C/A cg07884673 chr3:53033167 SFMBT1 -0.45 -6.07 -0.32 3.54e-9 Myopia (pathological);Plateletcrit; CRC cis rs6840360 0.557 rs4696261 chr4:152322659 C/G cg09659197 chr4:152720779 NA 0.33 6.32 0.33 8.5e-10 Intelligence (multi-trait analysis); CRC cis rs17155006 0.638 rs2074747 chr7:107744735 G/A cg05962710 chr7:107745446 LAMB4 -0.43 -7.58 -0.39 3.63e-13 Pneumococcal bacteremia; CRC cis rs1862618 0.853 rs832584 chr5:56179212 A/G cg22800045 chr5:56110881 MAP3K1 -0.55 -6.43 -0.33 4.48e-10 Initial pursuit acceleration; CRC cis rs7772486 0.754 rs6910790 chr6:146255330 G/A cg13319975 chr6:146136371 FBXO30 0.41 6.24 0.33 1.32e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs806794 1.000 rs806794 chr6:26200677 A/G cg13736514 chr6:26305472 NA -0.42 -6.96 -0.36 1.89e-11 Waist circumference;Hip circumference adjusted for BMI;Waist circumference adjusted for body mass index;Hip circumference;Height;Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction);Waist circumference adjusted for BMI in active individuals; CRC cis rs6089584 1.000 rs6089591 chr20:60570548 A/C cg13770153 chr20:60521292 NA -0.52 -8.5 -0.42 6.81e-16 Body mass index; CRC cis rs4319547 0.656 rs10161534 chr12:122873864 T/C cg23029597 chr12:123009494 RSRC2 -0.53 -6.58 -0.34 1.8e-10 Body mass index; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg24840228 chr9:131037543 C9orf119;GOLGA2 0.36 5.98 0.31 5.78e-9 Liver disease severity in Alagille syndrome; CRC cis rs116095464 0.558 rs62346526 chr5:220614 T/C cg22857025 chr5:266934 NA -1.23 -16.9 -0.68 1.4300000000000001e-46 Breast cancer; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg14561672 chr9:139014975 NA -0.39 -6.23 -0.32 1.44e-9 Myopia (pathological); CRC cis rs9368481 0.761 rs12661756 chr6:27003483 A/G cg07220782 chr6:26987966 LOC100270746;C6orf41 0.4 5.65 0.3 3.54e-8 Autism spectrum disorder or schizophrenia; CRC cis rs1150668 0.768 rs1233713 chr6:28198281 A/G cg15786705 chr6:28176104 NA 0.42 6.31 0.33 8.97e-10 Pubertal anthropometrics; CRC cis rs863345 0.535 rs12068285 chr1:158499632 G/A cg12129480 chr1:158549410 OR10X1 -0.3 -6.18 -0.32 1.88e-9 Pneumococcal bacteremia; CRC cis rs2652834 1.000 rs2652834 chr15:63396867 A/G cg05507819 chr15:63340323 TPM1 0.46 6.05 0.32 3.88e-9 HDL cholesterol; CRC cis rs10924970 0.625 rs10925127 chr1:235378659 C/T cg09010748 chr1:235293032 TOMM20 -0.4 -5.68 -0.3 2.98e-8 Asthma; CRC cis rs7208859 0.673 rs9911989 chr17:29237702 A/C cg13385521 chr17:29058706 SUZ12P -0.71 -8.19 -0.41 6.02e-15 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs9549260 0.755 rs9532577 chr13:41231542 A/G cg21288729 chr13:41239152 FOXO1 0.47 7.46 0.38 7.57e-13 Red blood cell count; CRC cis rs7927771 0.832 rs56030824 chr11:47397353 G/A cg20307385 chr11:47447363 PSMC3 -0.61 -8.59 -0.43 3.65e-16 Subjective well-being; CRC cis rs59104589 0.617 rs62193220 chr2:242353493 G/A cg19488206 chr2:242435732 STK25 0.43 6.4 0.33 5.37e-10 Fibrinogen levels; CRC cis rs7809950 0.773 rs62483722 chr7:107186349 C/T cg23024343 chr7:107201750 COG5 -0.61 -8.69 -0.43 1.69e-16 Coronary artery disease; CRC cis rs12824058 0.831 rs4759450 chr12:130812732 G/A cg24838063 chr12:130822603 PIWIL1 0.58 9.76 0.47 6.18e-20 Menopause (age at onset); CRC cis rs3617 0.573 rs4687680 chr3:52907372 G/A cg15147215 chr3:52552868 STAB1 -0.43 -7.02 -0.36 1.28e-11 Red blood cell count;Autism spectrum disorder or schizophrenia; CRC cis rs6570726 0.599 rs9403725 chr6:145897622 A/T cg05347473 chr6:146136440 FBXO30 -0.46 -6.68 -0.35 1.04e-10 Lobe attachment (rater-scored or self-reported); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg11355319 chr5:89825117 LYSMD3 0.41 6.0 0.31 5.34e-9 Intelligence (multi-trait analysis); CRC cis rs2839186 0.872 rs13052495 chr21:47707474 G/A cg09417038 chr21:47716443 C21orf57 -0.42 -6.93 -0.36 2.21e-11 Testicular germ cell tumor; CRC cis rs11255291 1.000 rs11255291 chr10:7736904 C/T cg00997801 chr10:7671259 ITIH5 0.4 5.81 0.31 1.44e-8 Ovarian reserve; CRC cis rs9400271 0.632 rs949882 chr6:109586062 A/G cg01475377 chr6:109611718 NA 0.35 6.0 0.31 5.11e-9 Sum neutrophil eosinophil counts;Sum basophil neutrophil counts;White blood cell count;Neutrophil count;Myeloid white cell count;Granulocyte count; CRC cis rs6502050 0.835 rs8077772 chr17:80117220 A/G cg09264619 chr17:80180166 NA 0.35 5.84 0.31 1.25e-8 Life satisfaction; CRC cis rs6570726 0.791 rs11155426 chr6:145817130 T/C cg13319975 chr6:146136371 FBXO30 -0.46 -6.85 -0.35 3.74e-11 Lobe attachment (rater-scored or self-reported); CRC cis rs4780401 0.901 rs34774904 chr16:11817107 G/A cg01061890 chr16:11836724 TXNDC11 -0.41 -5.61 -0.3 4.32e-8 Rheumatoid arthritis; CRC cis rs6912958 0.712 rs7755167 chr6:88338752 T/C cg12350822 chr6:88032061 C6orf162;GJB7 -0.32 -6.01 -0.31 5e-9 Monocyte percentage of white cells; CRC cis rs7727544 1.000 rs7727038 chr5:131590257 C/T cg12564285 chr5:131593104 PDLIM4 0.4 7.74 0.39 1.24e-13 Blood metabolite levels; CRC cis rs7618915 0.501 rs3774366 chr3:52641255 T/C cg18404041 chr3:52824283 ITIH1 -0.41 -8.57 -0.43 4.05e-16 Bipolar disorder; CRC trans rs6446298 0.738 rs1060970 chr3:49708769 T/C cg21665057 chr3:196295764 WDR53;FBXO45 -0.56 -6.62 -0.34 1.45e-10 Intelligence (multi-trait analysis); CRC cis rs7725052 0.544 rs6451500 chr5:40448195 C/G cg09067459 chr5:40385259 NA 0.38 6.37 0.33 6.42e-10 Pediatric autoimmune diseases; CRC cis rs6540559 0.611 rs17015226 chr1:209970096 C/G cg23283495 chr1:209979779 IRF6 0.46 6.56 0.34 2.06e-10 Cleft lip with or without cleft palate; CRC trans rs61931739 0.534 rs11053131 chr12:34282109 A/G cg26384229 chr12:38710491 ALG10B 0.47 6.75 0.35 6.71e-11 Morning vs. evening chronotype; CRC cis rs12760731 0.511 rs10429850 chr1:178612000 A/G cg00404053 chr1:178313656 RASAL2 0.58 6.88 0.35 2.96e-11 Obesity-related traits; CRC cis rs12541635 0.966 rs1496182 chr8:107024505 C/T cg10147462 chr8:107024639 NA 0.46 7.78 0.39 9.16e-14 Age of smoking initiation; CRC cis rs6446731 0.614 rs6446727 chr4:3274488 T/A cg16416165 chr4:3325029 RGS12 0.38 5.71 0.3 2.54e-8 Mean platelet volume; CRC cis rs1552244 0.882 rs3846168 chr3:9996925 C/T cg18598329 chr3:10140678 FANCD2;C3orf24 -0.8 -10.74 -0.51 2.81e-23 Alzheimer's disease; CRC cis rs10751667 1.000 rs6597972 chr11:928402 C/T ch.11.42038R chr11:967971 AP2A2 0.7 11.7 0.54 1.08e-26 Alzheimer's disease (late onset); CRC cis rs6748734 1.000 rs6751693 chr2:241837332 T/C cg04034577 chr2:241836375 C2orf54 -0.42 -8.55 -0.43 4.63e-16 Urinary metabolites; CRC cis rs10504229 1.000 rs57624567 chr8:58176995 T/C cg02725872 chr8:58115012 NA -0.38 -6.43 -0.33 4.44e-10 Developmental language disorder (linguistic errors); CRC cis rs9443645 0.810 rs9448610 chr6:79739622 G/A cg05283184 chr6:79620031 NA -0.57 -8.76 -0.43 1.04e-16 Intelligence (multi-trait analysis); CRC cis rs7680126 0.596 rs12511337 chr4:10311972 A/G cg11266682 chr4:10021025 SLC2A9 0.43 6.46 0.34 3.86e-10 Urate levels in lean individuals;Urate levels in overweight individuals;Urate levels in obese individuals; CRC cis rs10463316 0.862 rs13354553 chr5:150758128 G/A cg03212797 chr5:150827313 SLC36A1 -0.54 -8.52 -0.43 5.82e-16 Metabolite levels (Pyroglutamine); CRC cis rs7618501 0.633 rs2353579 chr3:50027774 C/T cg24308560 chr3:49941425 MST1R -0.53 -8.9 -0.44 3.75e-17 Intelligence (multi-trait analysis); CRC cis rs11711311 0.955 rs1048892 chr3:113464859 A/G cg15478005 chr3:113465772 ATP6V1A;NAA50 0.45 6.19 0.32 1.8e-9 IgG glycosylation; CRC trans rs3733585 0.673 rs4292332 chr4:9953830 C/A cg26043149 chr18:55253948 FECH -0.5 -7.71 -0.39 1.51e-13 Cleft plate (environmental tobacco smoke interaction); CRC cis rs12477438 0.520 rs2516835 chr2:99779131 T/C cg26064155 chr2:99771622 LIPT1;TSGA10 0.77 13.13 0.59 5.79e-32 Chronic sinus infection; CRC cis rs208520 0.633 rs7738469 chr6:66807446 T/C cg07460842 chr6:66804631 NA -1.08 -15.3 -0.64 2.83e-40 Exhaled nitric oxide output; CRC cis rs11190604 1.000 rs3793771 chr10:102222957 C/G cg16342193 chr10:102329863 NA -0.35 -5.73 -0.3 2.32e-8 Palmitoleic acid (16:1n-7) levels; CRC cis rs6952808 1.000 rs6952808 chr7:1886535 C/G cg22963979 chr7:1858916 MAD1L1 -0.58 -9.18 -0.45 4.97e-18 Bipolar disorder and schizophrenia; CRC cis rs3733585 0.673 rs4495037 chr4:9954050 C/G cg00071950 chr4:10020882 SLC2A9 -0.55 -9.74 -0.47 7.09e-20 Cleft plate (environmental tobacco smoke interaction); CRC cis rs2268241 0.938 rs7283827 chr21:34769904 A/G cg14850771 chr21:34775459 IFNGR2 0.79 10.54 0.5 1.45e-22 Obesity-related traits; CRC cis rs9467603 0.925 rs1954598 chr6:25776060 T/C cg16898833 chr6:26189333 HIST1H4D -0.69 -5.9 -0.31 9.01e-9 Intelligence (multi-trait analysis); CRC cis rs1448094 0.511 rs17345272 chr12:86165334 A/C cg02569458 chr12:86230093 RASSF9 0.46 7.46 0.38 7.87e-13 Major depressive disorder; CRC cis rs2014572 0.967 rs4801452 chr19:57768066 A/G cg24459738 chr19:57751996 ZNF805 -0.58 -9.13 -0.45 6.92e-18 Hyperactive-impulsive symptoms; CRC cis rs9372498 0.505 rs62422250 chr6:118990182 T/C cg10217327 chr6:118973057 C6orf204 0.54 5.62 0.3 4.04e-8 Diastolic blood pressure; CRC cis rs2072510 0.593 rs2660838 chr12:96416383 T/C cg09636302 chr12:96389483 HAL -0.51 -6.28 -0.33 1.05e-9 Metabolite levels (small molecules and protein measures); CRC cis rs736408 0.546 rs3733046 chr3:52621627 C/T cg05573699 chr3:52720067 GNL3;PBRM1 -0.47 -6.87 -0.35 3.28e-11 Bipolar disorder; CRC cis rs950169 1.000 rs11638394 chr15:84778928 G/A cg03959625 chr15:84868606 LOC388152 0.42 6.36 0.33 6.88e-10 Schizophrenia; CRC trans rs11764590 0.715 rs11760737 chr7:2104055 T/C cg11693508 chr17:37793320 STARD3 0.59 6.71 0.35 8.43e-11 Neuroticism; CRC cis rs2769264 0.505 rs11801791 chr1:151387508 C/T cg18801370 chr1:151430492 POGZ 0.57 6.66 0.34 1.19e-10 Blood trace element (Cu levels); CRC cis rs12048904 0.505 rs11166511 chr1:101240686 G/C cg00063077 chr1:101360652 SLC30A7;EXTL2 -0.7 -10.27 -0.49 1.17e-21 Multiple sclerosis; CRC cis rs10911232 0.507 rs10797814 chr1:182990929 C/A ch.1.3577855R chr1:183094577 LAMC1 0.86 15.17 0.64 8.93e-40 Hypertriglyceridemia; CRC cis rs739401 0.595 rs2237903 chr11:2967901 C/T cg25174290 chr11:3078921 CARS 0.4 6.07 0.32 3.48e-9 Longevity; CRC cis rs2797160 1.000 rs1777222 chr6:126021030 C/T cg05901451 chr6:126070800 HEY2 0.39 6.02 0.31 4.71e-9 Endometrial cancer; CRC cis rs6502050 0.799 rs12603050 chr17:80104631 A/G cg02741985 chr17:80059408 CCDC57 0.43 7.15 0.37 5.66e-12 Life satisfaction; CRC cis rs853679 0.517 rs9380065 chr6:28144751 A/G cg25164649 chr6:28176230 NA 0.78 9.69 0.47 1.04e-19 Depression; CRC cis rs2576037 0.583 rs2187091 chr18:44520048 T/C cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.58 -8.74 -0.43 1.23e-16 Personality dimensions; CRC cis rs68170813 0.559 rs12536574 chr7:106810997 A/T cg02696742 chr7:106810147 HBP1 -0.62 -6.84 -0.35 3.77e-11 Coronary artery disease; CRC cis rs6977660 0.653 rs28537170 chr7:19814239 T/G cg07541023 chr7:19748670 TWISTNB 0.57 5.63 0.3 3.85e-8 Thyroid stimulating hormone; CRC cis rs1568889 1.000 rs12802830 chr11:28321196 G/T cg06544937 chr11:28130018 METT5D1;KIF18A 0.79 10.67 0.51 5.12e-23 Bipolar disorder; CRC cis rs73206853 0.764 rs59527539 chr12:110968119 A/G cg12870014 chr12:110450643 ANKRD13A 0.81 9.47 0.46 5.52e-19 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC cis rs7085104 0.572 rs284856 chr10:104574329 A/T cg11453585 chr10:104263688 ACTR1A;SUFU 0.41 5.93 0.31 7.51e-9 Immature fraction of reticulocytes;Schizophrenia; CRC trans rs7618501 1.000 rs7372725 chr3:49790544 C/A cg21665057 chr3:196295764 WDR53;FBXO45 -0.87 -15.74 -0.66 5.06e-42 Intelligence (multi-trait analysis); CRC cis rs763121 0.853 rs7289577 chr22:39042214 C/G cg06544989 chr22:39130855 UNC84B 0.44 6.84 0.35 3.76e-11 Menopause (age at onset); CRC cis rs2223471 0.840 rs2744495 chr6:50756663 T/C cg03432817 chr6:50765336 NA 0.4 6.5 0.34 3.01e-10 Subcutaneous adipose tissue; CRC cis rs10504229 0.953 rs57131327 chr8:58171895 T/C cg02290350 chr8:58132656 NA -0.42 -5.96 -0.31 6.62e-9 Developmental language disorder (linguistic errors); CRC cis rs765787 0.530 rs3759893 chr15:45542950 G/T cg24006582 chr15:45444508 DUOX1 -0.56 -8.57 -0.43 4.1e-16 Uric acid levels; CRC trans rs1814175 0.559 rs1818892 chr11:49863084 C/A cg15704280 chr7:45808275 SEPT13 -0.94 -16.65 -0.68 1.36e-45 Height; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg13617204 chr6:27832869 HIST1H2AL 0.38 5.98 0.31 5.87e-9 Response to antipsychotic treatment; CRC cis rs6502050 0.835 rs12051747 chr17:80114814 T/C cg25804541 chr17:80189381 SLC16A3 -0.29 -5.69 -0.3 2.75e-8 Life satisfaction; CRC cis rs6502050 0.805 rs4789720 chr17:80157490 G/C cg22110888 chr17:80059540 CCDC57 0.38 6.07 0.32 3.61e-9 Life satisfaction; CRC cis rs6582630 0.555 rs12828034 chr12:38274249 C/T cg26384229 chr12:38710491 ALG10B -0.51 -7.35 -0.38 1.63e-12 Drug-induced liver injury (flucloxacillin); CRC cis rs6960043 0.818 rs10238161 chr7:15053827 A/T cg19272540 chr7:15055459 NA 0.25 6.66 0.34 1.17e-10 Type 2 diabetes; CRC cis rs1552244 1.000 rs6791810 chr3:10124444 A/G cg00166722 chr3:10149974 C3orf24 -0.68 -9.35 -0.46 1.43e-18 Alzheimer's disease; CRC cis rs1552244 0.554 rs3732964 chr3:10048839 C/G cg18598329 chr3:10140678 FANCD2;C3orf24 -0.54 -7.67 -0.39 1.98e-13 Alzheimer's disease; CRC cis rs2882667 0.898 rs4380651 chr5:138391072 A/G cg09476006 chr5:138032270 NA 0.44 7.34 0.38 1.7e-12 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs35306767 0.903 rs4522091 chr10:874116 G/T cg20503657 chr10:835505 NA 0.91 11.03 0.52 2.69e-24 Eosinophil percentage of granulocytes; CRC cis rs7786808 0.707 rs62479983 chr7:158227613 G/A cg01191920 chr7:158217561 PTPRN2 -0.89 -16.93 -0.68 1.12e-46 Obesity-related traits; CRC cis rs9549367 0.789 rs8001506 chr13:113867153 A/C cg00898013 chr13:113819073 PROZ -0.39 -5.72 -0.3 2.42e-8 Platelet distribution width; CRC trans rs1814175 0.708 rs10839464 chr11:49981386 T/C cg15704280 chr7:45808275 SEPT13 -0.94 -16.88 -0.68 1.75e-46 Height; CRC cis rs2070488 1.000 rs13072809 chr3:38468171 G/A cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.9 16.3 0.67 3.49e-44 Electrocardiographic conduction measures; CRC cis rs7618915 0.533 rs35107891 chr3:52613656 G/C cg08222913 chr3:52553049 STAB1 -0.34 -6.27 -0.33 1.14e-9 Bipolar disorder; CRC cis rs12451471 0.667 rs12942002 chr17:78101629 C/G cg08347473 chr17:78092826 GAA -0.35 -5.76 -0.3 1.92e-8 Plateletcrit;Mean corpuscular hemoglobin concentration; CRC trans rs116095464 0.558 rs10055405 chr5:265666 C/T cg00938859 chr5:1591904 SDHAP3 0.73 7.88 0.4 4.81e-14 Breast cancer; CRC cis rs4356975 0.563 rs11932131 chr4:69949547 G/T cg25583503 chr4:69962676 UGT2B7 -0.31 -5.68 -0.3 2.92e-8 Obesity-related traits; CRC cis rs17376456 0.825 rs28645862 chr5:93233128 G/C cg25358565 chr5:93447407 FAM172A 1.06 10.61 0.5 8.48e-23 Diabetic retinopathy; CRC cis rs4713118 0.955 rs9380010 chr6:27683572 A/G cg25164649 chr6:28176230 NA 0.54 7.3 0.37 2.13e-12 Parkinson's disease; CRC cis rs758324 0.891 rs635164 chr5:131312874 C/T cg06307176 chr5:131281290 NA -0.41 -6.02 -0.32 4.58e-9 Alzheimer's disease in APOE e4- carriers; CRC cis rs11122272 0.705 rs2491411 chr1:231533448 C/G cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.58 -8.61 -0.43 2.98e-16 Hemoglobin concentration; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg08785274 chr1:161068252 KLHDC9 0.42 6.27 0.33 1.14e-9 Response to antipsychotic treatment; CRC cis rs6089584 0.893 rs6089306 chr20:60574868 G/A cg06108461 chr20:60628389 TAF4 -0.7 -11.96 -0.55 1.24e-27 Body mass index; CRC trans rs9825823 0.617 rs2083264 chr3:61074229 A/G cg09423085 chr2:68478351 PPP3R1 0.44 6.17 0.32 2.01e-9 Depressive symptom measurement or major depressive disorder; CRC cis rs9322193 0.923 rs9404048 chr6:149937324 C/T cg00933542 chr6:150070202 PCMT1 0.3 6.3 0.33 9.49e-10 Lung cancer; CRC cis rs3617 0.625 rs11715347 chr3:52883070 C/T cg11645453 chr3:52864694 ITIH4 -0.46 -9.31 -0.46 1.92e-18 Red blood cell count;Autism spectrum disorder or schizophrenia; CRC cis rs763121 0.853 rs2413545 chr22:39092524 C/T cg06022373 chr22:39101656 GTPBP1 0.78 11.32 0.53 2.65e-25 Menopause (age at onset); CRC trans rs208520 0.874 rs208469 chr6:66915891 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.88 -11.77 -0.54 6.15e-27 Exhaled nitric oxide output; CRC cis rs853679 0.517 rs2281588 chr6:28072602 G/A cg23161317 chr6:28129485 ZNF389 0.52 6.35 0.33 6.97e-10 Depression; CRC cis rs9326248 0.798 rs10892079 chr11:117016824 T/G cg10130564 chr11:117069849 TAGLN 0.34 5.91 0.31 8.76e-9 Blood protein levels; CRC cis rs2239547 0.522 rs6770957 chr3:52995416 T/C cg18404041 chr3:52824283 ITIH1 -0.36 -6.76 -0.35 6.2e-11 Schizophrenia; CRC cis rs11098499 0.865 rs11722183 chr4:120280597 A/C cg24375607 chr4:120327624 NA 0.5 7.66 0.39 2.05e-13 Corneal astigmatism; CRC cis rs9611565 0.592 rs5758406 chr22:42076641 A/G cg03806693 chr22:41940476 POLR3H 0.98 12.83 0.58 8.19e-31 Vitiligo; CRC cis rs1799949 1.000 rs4793190 chr17:41200109 T/C cg05368731 chr17:41323189 NBR1 0.68 10.3 0.49 9.6e-22 Menopause (age at onset); CRC cis rs9640161 0.742 rs11767726 chr7:150018096 A/C cg12556325 chr7:150026731 C7orf29;LRRC61 0.39 6.06 0.32 3.62e-9 Blood protein levels;Circulating chemerin levels; CRC cis rs941873 0.900 rs4979862 chr10:81131599 G/A cg09469691 chr10:81107165 PPIF 0.54 8.47 0.42 8.21e-16 Height; CRC cis rs9517320 0.534 rs61971163 chr13:99188883 G/A cg20487152 chr13:99095054 FARP1 -0.46 -6.65 -0.34 1.19e-10 Longevity; CRC cis rs6426558 0.502 rs6697665 chr1:227474665 T/C cg10327440 chr1:227177885 CDC42BPA 0.42 6.35 0.33 7.12e-10 Neutrophil percentage of white cells; CRC cis rs9467711 0.559 rs12176129 chr6:26514940 C/T cg16898833 chr6:26189333 HIST1H4D 0.82 7.16 0.37 5.26e-12 Autism spectrum disorder or schizophrenia; CRC cis rs9811920 0.609 rs6440938 chr3:99652092 T/C cg07805332 chr3:99536008 MIR548G;C3orf26 0.51 7.68 0.39 1.84e-13 Axial length; CRC cis rs3858526 0.584 rs10769270 chr11:5860563 T/C cg05234568 chr11:5960015 NA -0.63 -8.83 -0.44 6.39e-17 DNA methylation (variation); CRC cis rs6460942 1.000 rs7796485 chr7:12405676 G/A cg20607287 chr7:12443886 VWDE -0.64 -6.66 -0.34 1.15e-10 Coronary artery disease; CRC cis rs2811415 0.597 rs11719889 chr3:127805780 G/A cg13719885 chr3:127795394 NA -0.39 -5.91 -0.31 8.77e-9 Lung function (FEV1/FVC); CRC cis rs4713118 0.513 rs149878 chr6:27878738 T/G cg21251018 chr6:28226885 NKAPL 0.54 8.51 0.42 6.19e-16 Parkinson's disease; CRC cis rs9911578 0.967 rs12603238 chr17:57130785 C/T cg12560992 chr17:57184187 TRIM37 -0.95 -17.81 -0.7 3.86e-50 Intelligence (multi-trait analysis); CRC cis rs9818758 0.556 rs9814987 chr3:49207849 T/C cg07636037 chr3:49044803 WDR6 -0.66 -5.97 -0.31 6.31e-9 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; CRC cis rs559928 0.548 rs11231713 chr11:63931849 C/T cg19465662 chr11:63993652 NUDT22;TRPT1 0.68 6.38 0.33 6.16e-10 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; CRC cis rs11971779 0.680 rs2355785 chr7:139070983 C/A cg07862535 chr7:139043722 LUC7L2 0.57 7.35 0.38 1.61e-12 Diisocyanate-induced asthma; CRC cis rs9916302 0.851 rs7225096 chr17:37664443 T/C cg15445000 chr17:37608096 MED1 0.43 9.5 0.46 4.37e-19 Glomerular filtration rate (creatinine); CRC cis rs703842 1.000 rs2072052 chr12:58146719 A/C cg00677455 chr12:58241039 CTDSP2 0.65 8.67 0.43 2.06e-16 Multiple sclerosis; CRC cis rs4363385 0.588 rs6661059 chr1:153027257 A/T cg25856811 chr1:152973957 SPRR3 -0.23 -6.26 -0.33 1.2e-9 Inflammatory skin disease; CRC cis rs7927771 0.801 rs12798028 chr11:47604639 C/T cg18512352 chr11:47633146 NA -0.37 -7.33 -0.37 1.75e-12 Subjective well-being; CRC cis rs2346177 0.580 rs7565770 chr2:46683683 A/C cg26688816 chr2:46740690 ATP6V1E2 -0.59 -10.0 -0.48 9.9e-21 HDL cholesterol; CRC trans rs79976124 0.837 rs10455591 chr6:66650584 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.76 9.55 0.47 3.03e-19 Type 2 diabetes; CRC cis rs9894429 0.646 rs7406522 chr17:79615396 G/T cg21028142 chr17:79581711 NPLOC4 0.34 7.01 0.36 1.35e-11 Eye color traits; CRC cis rs10256972 0.552 rs2960831 chr7:1201192 A/T cg16145915 chr7:1198662 ZFAND2A -0.53 -11.4 -0.53 1.39e-25 Longevity;Endometriosis; CRC cis rs853679 0.550 rs1237875 chr6:28173010 A/G cg12172441 chr6:28176163 NA -0.69 -9.21 -0.45 3.79e-18 Depression; CRC cis rs2115630 0.967 rs10438428 chr15:85330745 C/T cg09876464 chr15:85330779 ZNF592 0.48 8.4 0.42 1.36e-15 P wave terminal force; CRC cis rs12950390 0.853 rs11655336 chr17:45858836 A/G cg24803719 chr17:45855879 NA 0.3 6.73 0.35 7.52e-11 IgG glycosylation; CRC cis rs769267 0.895 rs2965182 chr19:19548246 A/G cg01262667 chr19:19385393 TM6SF2 0.35 5.75 0.3 2e-8 Tonsillectomy; CRC cis rs1005277 0.579 rs2472182 chr10:38388865 T/C cg17219203 chr10:38645113 HSD17B7P2 -0.41 -5.76 -0.3 1.9e-8 Extrinsic epigenetic age acceleration; CRC cis rs7412746 0.611 rs4509581 chr1:150774465 A/G cg17724175 chr1:150552817 MCL1 0.47 7.01 0.36 1.35e-11 Melanoma; CRC cis rs13191362 0.872 rs13215538 chr6:163037975 T/C cg21926612 chr6:163149169 PACRG;PARK2 0.94 12.18 0.56 2.01e-28 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs7412746 0.658 rs1027699 chr1:150811712 T/C cg15448220 chr1:150897856 SETDB1 0.56 7.98 0.4 2.41e-14 Melanoma; CRC cis rs8030485 0.756 rs2102999 chr15:79410710 C/T cg17916960 chr15:79447300 NA -0.35 -5.7 -0.3 2.71e-8 Left ventricle wall thickness; CRC cis rs10464366 0.912 rs2030960 chr7:39106010 G/A cg18850127 chr7:39170497 POU6F2 0.5 6.43 0.33 4.42e-10 IgG glycosylation; CRC cis rs7147624 1.000 rs61987807 chr14:66207050 G/T cg03016385 chr14:66212404 NA -1.04 -10.44 -0.5 3.06e-22 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs2734839 0.964 rs2734831 chr11:113293596 G/T cg14159747 chr11:113255604 NA -0.41 -7.16 -0.37 5.25e-12 Information processing speed; CRC cis rs9522267 0.535 rs914031 chr13:112240176 C/A cg26182253 chr13:112236782 NA 0.31 6.25 0.33 1.3e-9 Hepatitis; CRC cis rs10782582 0.593 rs11802717 chr1:76124648 C/T cg10523679 chr1:76189770 ACADM -0.4 -5.66 -0.3 3.28e-8 Daytime sleep phenotypes; CRC cis rs972578 1.000 rs4820502 chr22:43387915 C/A cg01576275 chr22:43409880 NA -0.49 -7.91 -0.4 3.96e-14 Mean platelet volume; CRC cis rs6701037 0.566 rs13373754 chr1:175139275 C/A cg00321850 chr1:175162397 KIAA0040 0.46 7.78 0.39 9.16e-14 Alcohol dependence; CRC cis rs17666538 0.792 rs1703912 chr8:600643 A/G cg07685180 chr8:600429 NA 0.86 8.6 0.43 3.32e-16 IgG glycosylation; CRC cis rs10924970 0.649 rs12729988 chr1:235372580 G/A cg09010748 chr1:235293032 TOMM20 -0.4 -5.64 -0.3 3.72e-8 Asthma; CRC cis rs2404602 0.684 rs12437981 chr15:76842401 A/G cg23625390 chr15:77176239 SCAPER -0.88 -14.65 -0.63 9.61e-38 Blood metabolite levels; CRC cis rs4713118 0.586 rs6905522 chr6:28086479 A/C cg12273811 chr6:28175739 NA 0.73 9.18 0.45 4.85e-18 Parkinson's disease; CRC cis rs6662572 0.703 rs17855317 chr1:46500613 T/C cg03123370 chr1:45965343 CCDC163P;MMACHC 0.46 5.95 0.31 6.91e-9 Blood protein levels; CRC cis rs1005277 0.540 rs4934907 chr10:38015230 A/C cg00409905 chr10:38381863 ZNF37A -0.64 -10.63 -0.51 6.96e-23 Extrinsic epigenetic age acceleration; CRC cis rs801193 0.569 rs11772819 chr7:66217970 T/C cg18252515 chr7:66147081 NA -0.41 -5.8 -0.3 1.58e-8 Aortic root size; CRC cis rs9325144 0.560 rs6582561 chr12:38666821 G/A cg26384229 chr12:38710491 ALG10B -0.55 -8.21 -0.41 5.22e-15 Morning vs. evening chronotype; CRC cis rs561341 1.000 rs56903735 chr17:30254393 T/A cg19193384 chr17:30244184 NA -0.49 -6.33 -0.33 7.9e-10 Hip circumference adjusted for BMI; CRC cis rs2251381 0.778 rs722013 chr21:30549245 G/T cg08807101 chr21:30365312 RNF160 0.66 9.67 0.47 1.29e-19 Selective IgA deficiency; CRC cis rs5750830 0.649 rs4337572 chr22:39800704 C/G cg11247378 chr22:39784982 NA -0.47 -9.29 -0.46 2.22e-18 Intelligence (multi-trait analysis); CRC cis rs3750082 0.603 rs2278818 chr7:32961180 C/T cg05721444 chr7:32995514 FKBP9 0.5 6.37 0.33 6.34e-10 Glomerular filtration rate (creatinine); CRC cis rs6952808 0.531 rs3778991 chr7:2172455 G/A cg02951883 chr7:2050386 MAD1L1 -0.61 -9.11 -0.45 8.21e-18 Bipolar disorder and schizophrenia; CRC cis rs992157 0.687 rs35271699 chr2:219117482 G/A cg00012203 chr2:219082015 ARPC2 0.62 10.38 0.5 5.16e-22 Colorectal cancer; CRC cis rs62408225 1.000 rs62408224 chr6:90955995 A/G cg06866423 chr6:90926672 BACH2 0.49 8.06 0.41 1.42e-14 Eosinophil counts;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC cis rs13343954 0.518 rs8106293 chr19:33536376 C/T cg17764715 chr19:33622953 WDR88 0.4 5.95 0.31 6.68e-9 Colorectal cancer; CRC cis rs9611565 0.729 rs2413646 chr22:41906325 C/T cg03806693 chr22:41940476 POLR3H -1.09 -13.91 -0.61 6.53e-35 Vitiligo; CRC cis rs2576037 0.899 rs12955429 chr18:44585484 C/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 -0.46 -7.25 -0.37 2.93e-12 Personality dimensions; CRC cis rs1552244 0.832 rs66597916 chr3:10195407 T/C cg08888203 chr3:10149979 C3orf24 0.65 7.55 0.38 4.33e-13 Alzheimer's disease; CRC cis rs758324 0.947 rs687816 chr5:131262077 C/T cg06307176 chr5:131281290 NA -0.42 -6.28 -0.33 1.05e-9 Alzheimer's disease in APOE e4- carriers; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg14056668 chr15:52122448 TMOD3 0.51 7.19 0.37 4.32e-12 Response to antipsychotic treatment; CRC cis rs1949733 0.598 rs4696838 chr4:8540349 A/G cg11789530 chr4:8429930 ACOX3 -0.59 -7.99 -0.4 2.33e-14 Response to antineoplastic agents; CRC cis rs10751667 0.557 rs12281858 chr11:1022187 C/T cg23136738 chr11:925521 AP2A2 -0.38 -5.85 -0.31 1.2e-8 Alzheimer's disease (late onset); CRC cis rs9796 0.558 rs7166205 chr15:41514733 A/G cg18705301 chr15:41695430 NDUFAF1 -0.4 -6.62 -0.34 1.44e-10 Menopause (age at onset); CRC cis rs17711722 0.510 rs73142128 chr7:65331109 A/C cg18876405 chr7:65276391 NA 0.5 8.08 0.41 1.25e-14 Calcium levels; CRC cis rs7552404 0.690 rs7549863 chr1:76327923 T/C cg05598546 chr1:76251766 SNORD45C;RABGGTB -0.51 -5.87 -0.31 1.06e-8 Blood metabolite levels;Acylcarnitine levels; CRC cis rs11123170 0.640 rs931472 chr2:113969948 C/T cg07772999 chr2:113993052 PAX8;LOC440839;LOC654433 -0.45 -5.95 -0.31 6.96e-9 Renal function-related traits (BUN); CRC cis rs1862618 0.853 rs3099459 chr5:56137170 G/C cg03609598 chr5:56110824 MAP3K1 -0.81 -9.8 -0.48 4.51e-20 Initial pursuit acceleration; CRC cis rs3617 0.573 rs4687680 chr3:52907372 G/A cg10802521 chr3:52805072 NEK4 -0.39 -5.97 -0.31 6e-9 Red blood cell count;Autism spectrum disorder or schizophrenia; CRC trans rs10243593 0.698 rs10275761 chr7:40073282 A/G cg13911576 chr9:84174038 NA 0.34 6.0 0.31 5.32e-9 Lymphocyte counts; CRC cis rs7917772 0.636 rs4418737 chr10:104525123 A/G cg11453585 chr10:104263688 ACTR1A;SUFU -0.69 -10.28 -0.49 1.15e-21 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC cis rs3820068 0.705 rs58424111 chr1:15868470 A/C cg27534772 chr1:16042836 PLEKHM2 0.42 6.97 0.36 1.78e-11 Systolic blood pressure; CRC cis rs7914558 1.000 rs10883824 chr10:104812897 A/G cg04362960 chr10:104952993 NT5C2 0.6 9.12 0.45 7.86e-18 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs727505 1.000 rs12111865 chr7:124498035 G/A cg23710748 chr7:124431027 NA -0.68 -12.21 -0.56 1.6e-28 Lewy body disease; CRC cis rs763121 0.962 rs5757130 chr22:38937794 G/A cg06544989 chr22:39130855 UNC84B 0.47 7.44 0.38 8.66e-13 Menopause (age at onset); CRC cis rs4481887 0.927 rs4460676 chr1:248431781 G/A cg00666640 chr1:248458726 OR2T12 0.58 10.26 0.49 1.31e-21 Common traits (Other); CRC cis rs28386778 0.897 rs3744293 chr17:61841788 T/A cg11494091 chr17:61959527 GH2 0.63 10.73 0.51 3.01e-23 Prudent dietary pattern; CRC cis rs7666738 0.830 rs17484966 chr4:99014432 T/C cg17366294 chr4:99064904 C4orf37 0.44 7.35 0.38 1.55e-12 Colonoscopy-negative controls vs population controls; CRC trans rs9291683 0.525 rs12506455 chr4:10031569 T/A cg26043149 chr18:55253948 FECH 0.53 8.1 0.41 1.12e-14 Bone mineral density; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg22161983 chr8:103818636 NA 0.51 7.61 0.39 2.82e-13 Intelligence (multi-trait analysis); CRC cis rs595982 0.559 rs17272680 chr19:49364511 A/G cg21252483 chr19:49399788 TULP2 0.37 6.1 0.32 2.93e-9 Red cell distribution width; CRC cis rs10504229 0.953 rs6991035 chr8:58183374 C/T cg01721255 chr8:58191610 C8orf71 0.49 6.17 0.32 2e-9 Developmental language disorder (linguistic errors); CRC cis rs4074493 0.928 rs4310430 chr1:231172881 T/G cg22172038 chr1:231176991 FAM89A 0.34 5.86 0.31 1.14e-8 Carotid plaque burden (smoking interaction); CRC cis rs11098499 0.644 rs2389880 chr4:120559870 T/A cg24375607 chr4:120327624 NA 0.47 7.37 0.38 1.41e-12 Corneal astigmatism; CRC cis rs270601 0.770 rs61352298 chr5:131600589 G/C cg20512303 chr5:131592959 PDLIM4 0.4 7.58 0.39 3.67e-13 Acylcarnitine levels; CRC cis rs7811142 1.000 rs6972167 chr7:100080013 G/T cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.6 7.81 0.4 7.89e-14 Platelet count; CRC cis rs12681287 0.640 rs6992944 chr8:87419308 G/T cg27223183 chr8:87520930 FAM82B 0.51 6.96 0.36 1.87e-11 Caudate activity during reward; CRC cis rs1949733 0.958 rs2631731 chr4:8429817 A/G cg13073564 chr4:8508604 NA -0.47 -7.03 -0.36 1.22e-11 Response to antineoplastic agents; CRC cis rs6952808 0.531 rs73039217 chr7:2178731 G/A cg22963979 chr7:1858916 MAD1L1 -0.41 -5.76 -0.3 1.94e-8 Bipolar disorder and schizophrenia; CRC cis rs34375054 0.624 rs73233307 chr12:125675873 G/C cg02766259 chr12:125626809 AACS -0.48 -7.73 -0.39 1.29e-13 Post bronchodilator FEV1/FVC ratio; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg04786791 chr1:218458496 RRP15 0.42 5.99 0.31 5.62e-9 Response to antipsychotic treatment; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg12651014 chr10:32735292 CCDC7 0.42 6.68 0.35 1.05e-10 Liver disease severity in Alagille syndrome; CRC cis rs1223397 0.651 rs2439535 chr6:13305822 C/T cg07912922 chr6:13274314 PHACTR1 0.39 5.95 0.31 6.78e-9 Blood pressure; CRC cis rs1873147 1.000 rs2130165 chr15:63314519 C/T cg12160578 chr15:63334699 TPM1 -0.41 -5.94 -0.31 7.42e-9 Orofacial clefts; CRC trans rs1728785 0.901 rs698715 chr16:68560896 A/G cg04657470 chr2:198365150 HSPE1;HSPD1 0.76 8.68 0.43 1.88e-16 Ulcerative colitis; CRC cis rs801193 0.660 rs1962050 chr7:66240008 C/T cg18876405 chr7:65276391 NA -0.46 -7.47 -0.38 7.34e-13 Aortic root size; CRC cis rs4563143 0.634 rs113736470 chr19:29240125 G/A cg14983838 chr19:29218262 NA 0.56 8.64 0.43 2.47e-16 Methadone dose in opioid dependence; CRC cis rs4481887 0.893 rs10158180 chr1:248481423 C/T cg13385794 chr1:248469461 NA 0.38 6.67 0.35 1.06e-10 Common traits (Other); CRC cis rs929354 1.000 rs1182378 chr7:157048322 T/C cg16102536 chr7:156981717 UBE3C -0.39 -6.68 -0.35 9.94e-11 Body mass index; CRC cis rs67311347 1.000 rs11706148 chr3:40407243 A/C cg09455208 chr3:40491958 NA 0.49 9.52 0.46 3.77e-19 Renal cell carcinoma; CRC cis rs2952156 0.684 rs1877031 chr17:37814080 G/A cg07936489 chr17:37558343 FBXL20 -0.52 -7.74 -0.39 1.27e-13 Asthma; CRC cis rs11098499 0.913 rs35271032 chr4:120156659 C/T cg09307838 chr4:120376055 NA 0.63 9.71 0.47 9.04e-20 Corneal astigmatism; CRC cis rs7255436 0.965 rs11666003 chr19:8452102 G/A cg10174797 chr19:8464628 RAB11B 0.44 7.69 0.39 1.67e-13 HDL cholesterol; CRC cis rs28386778 0.897 rs716880 chr17:61902822 C/G cg06873352 chr17:61820015 STRADA 0.77 14.46 0.62 5e-37 Prudent dietary pattern; CRC cis rs6662572 0.703 rs4660909 chr1:46477326 G/C cg03123370 chr1:45965343 CCDC163P;MMACHC -0.46 -6.0 -0.31 5.17e-9 Blood protein levels; CRC cis rs897984 0.683 rs8046001 chr16:30833321 C/T cg00531865 chr16:30841666 NA -0.52 -7.85 -0.4 5.78e-14 Dementia with Lewy bodies; CRC cis rs9486715 0.867 rs4839834 chr6:96882109 C/A cg18709589 chr6:96969512 KIAA0776 0.47 6.89 0.35 2.9100000000000002e-11 Headache; CRC cis rs4665809 0.590 rs62128455 chr2:26466530 G/A cg08067268 chr2:26466485 HADHB;HADHA 0.65 8.34 0.42 2e-15 Gut microbiome composition (summer); CRC cis rs7615952 0.641 rs12488180 chr3:125782236 C/T cg06494592 chr3:125709126 NA -0.56 -6.72 -0.35 8.11e-11 Blood pressure (smoking interaction); CRC cis rs12999616 0.817 rs62157581 chr2:98327502 G/T cg26665480 chr2:98280029 ACTR1B 0.52 6.43 0.33 4.6e-10 Colorectal cancer; CRC cis rs8077889 0.917 rs28694735 chr17:41912144 A/G cg25876840 chr17:41920477 NA 0.54 7.81 0.4 7.61e-14 Triglycerides; CRC cis rs7772486 0.875 rs10457795 chr6:146415665 A/G cg13319975 chr6:146136371 FBXO30 -0.4 -6.17 -0.32 2.02e-9 Lobe attachment (rater-scored or self-reported); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg21166047 chr9:7478187 NA -0.37 -5.97 -0.31 6.22e-9 Liver disease severity in Alagille syndrome; CRC cis rs7959452 0.640 rs4761154 chr12:69705362 A/G cg20891283 chr12:69753455 YEATS4 -0.78 -13.06 -0.58 1.08e-31 Blood protein levels; CRC trans rs208520 1.000 rs12212063 chr6:66985148 C/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.86 10.54 0.5 1.47e-22 Exhaled nitric oxide output; CRC cis rs13191362 0.935 rs67889271 chr6:163045753 T/G cg23758597 chr6:163146217 PARK2 -0.64 -6.28 -0.33 1.05e-9 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC trans rs7615952 0.546 rs11711150 chr3:125315663 C/T cg07211511 chr3:129823064 LOC729375 -0.61 -6.92 -0.36 2.42e-11 Blood pressure (smoking interaction); CRC cis rs2070488 0.775 rs1132064 chr3:38566519 T/C cg01465620 chr3:38496096 LOC100128640;ACVR2B -0.76 -12.49 -0.57 1.4e-29 Electrocardiographic conduction measures; CRC cis rs9916302 0.706 rs667239 chr17:37442241 A/G cg03013999 chr17:37608204 MED1 -0.45 -5.91 -0.31 8.39e-9 Glomerular filtration rate (creatinine); CRC cis rs11031096 0.711 rs10767881 chr11:4205122 C/G cg18678763 chr11:4115507 RRM1 -0.37 -5.85 -0.31 1.19e-8 Mean corpuscular volume;Mean corpuscular hemoglobin; CRC cis rs1179624 0.679 rs62475465 chr7:75265541 C/T cg05145297 chr7:75264568 HIP1 0.6 8.2 0.41 5.44e-15 Age-related nuclear cataracts; CRC cis rs4713118 0.955 rs9393848 chr6:27688369 C/T cg26587870 chr6:27730563 NA -0.42 -6.37 -0.33 6.51e-10 Parkinson's disease; CRC cis rs2013441 1.000 rs9897328 chr17:20174852 G/A cg13482628 chr17:19912719 NA -0.4 -6.15 -0.32 2.2e-9 Obesity-related traits; CRC cis rs12900413 0.603 rs12909833 chr15:90301518 G/A cg24249390 chr15:90295951 MESP1 -0.61 -9.28 -0.46 2.26e-18 Coronary artery aneurysm in Kawasaki disease; CRC cis rs4423214 1.000 rs12807718 chr11:71171170 T/C cg05163923 chr11:71159392 DHCR7 0.66 9.38 0.46 1.13e-18 Vitamin D levels; CRC cis rs1448094 0.511 rs10863083 chr12:86226739 C/A cg00310523 chr12:86230176 RASSF9 0.35 5.86 0.31 1.1e-8 Major depressive disorder; CRC cis rs9393692 0.620 rs9379842 chr6:26289310 C/T cg00631329 chr6:26305371 NA 0.53 9.05 0.45 1.24e-17 Educational attainment; CRC cis rs96067 0.711 rs272833 chr1:36622870 C/G cg24686825 chr1:36642396 MAP7D1 -0.52 -6.71 -0.35 8.6e-11 Corneal structure; CRC cis rs66569888 0.632 rs6728600 chr2:106898653 G/T cg16099169 chr2:106886729 NA -0.64 -10.22 -0.49 1.85e-21 Facial morphology (factor 23); CRC cis rs938554 0.513 rs3775947 chr4:9995240 C/T cg11266682 chr4:10021025 SLC2A9 0.35 6.16 0.32 2.16e-9 Blood metabolite levels; CRC cis rs801193 0.569 rs13226966 chr7:66233623 A/G cg00343986 chr7:65444356 GUSB 0.44 6.09 0.32 3.13e-9 Aortic root size; CRC cis rs4853012 0.838 rs4563249 chr2:74354016 G/T cg05890377 chr2:74357713 NA 0.68 11.44 0.53 9.34e-26 Gestational age at birth (maternal effect); CRC cis rs9341808 0.527 rs2505946 chr6:80810683 A/G cg08355045 chr6:80787529 NA 0.48 8.62 0.43 2.79e-16 Sitting height ratio; CRC cis rs6963495 0.818 rs73192125 chr7:105175068 A/C cg13798780 chr7:105162888 PUS7 0.54 6.91 0.36 2.46e-11 Bipolar disorder (body mass index interaction); CRC cis rs1448094 0.845 rs11117129 chr12:86349390 A/G cg18827107 chr12:86230957 RASSF9 -0.43 -6.85 -0.35 3.64e-11 Major depressive disorder; CRC cis rs2404602 0.716 rs7164813 chr15:76708066 T/C cg23625390 chr15:77176239 SCAPER 0.47 6.92 0.36 2.32e-11 Blood metabolite levels; CRC cis rs6500395 1.000 rs9931123 chr16:48614293 G/T cg04672837 chr16:48644449 N4BP1 0.44 6.6 0.34 1.69e-10 Response to tocilizumab in rheumatoid arthritis; CRC cis rs231513 0.954 rs231505 chr17:41970268 A/T cg26893861 chr17:41843967 DUSP3 0.57 5.79 0.3 1.64e-8 Cognitive function; CRC cis rs10191773 0.535 rs12477879 chr2:112969865 C/T cg24977338 chr2:113188963 RGPD8;RGPD5 -0.61 -5.95 -0.31 6.97e-9 Yeast infection; CRC cis rs2243480 1.000 rs4718317 chr7:65648901 A/G cg12463550 chr7:65579703 CRCP -0.65 -6.03 -0.32 4.49e-9 Diabetic kidney disease; CRC cis rs8180040 1.000 rs4858888 chr3:47405305 C/T cg10298567 chr3:47292165 KIF9 0.4 6.43 0.33 4.47e-10 Colorectal cancer; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg21441505 chr4:1714055 SLBP 0.38 6.08 0.32 3.4e-9 Intelligence (multi-trait analysis); CRC cis rs853679 0.607 rs200489 chr6:27798257 T/C cg19041857 chr6:27730383 NA -0.71 -6.65 -0.34 1.2e-10 Depression; CRC cis rs6951245 0.554 rs35126802 chr7:1134842 C/T cg22907277 chr7:1156413 C7orf50 0.81 10.52 0.5 1.6400000000000001e-22 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs2180341 0.961 rs910720 chr6:127619070 T/C cg24812749 chr6:127587940 RNF146 0.94 13.67 0.6 5.36e-34 Breast cancer; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg27089754 chr16:75590036 TMEM231 0.44 6.13 0.32 2.56e-9 Anxiety disorder; CRC trans rs1814175 0.527 rs10769595 chr11:49638212 A/G cg11707556 chr5:10655725 ANKRD33B -0.45 -7.43 -0.38 9.15e-13 Height; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg03301945 chr19:10764555 ILF3;LOC147727 0.45 6.33 0.33 7.96e-10 Anxiety disorder; CRC cis rs6840360 1.000 rs4696283 chr4:152580516 A/G cg09659197 chr4:152720779 NA 0.51 10.79 0.51 1.88e-23 Intelligence (multi-trait analysis); CRC cis rs10504229 1.000 rs67105789 chr8:58192002 G/T cg02290350 chr8:58132656 NA -0.42 -5.96 -0.31 6.62e-9 Developmental language disorder (linguistic errors); CRC cis rs2456568 0.802 rs10831139 chr11:93640537 G/A cg26875233 chr11:93583750 C11orf90 -0.31 -6.02 -0.32 4.6e-9 Response to serotonin reuptake inhibitors in major depressive disorder; CRC cis rs11690935 0.550 rs62183784 chr2:172866696 A/G cg13550731 chr2:172543902 DYNC1I2 0.61 8.8 0.44 7.61e-17 Schizophrenia; CRC cis rs12541635 0.739 rs1896915 chr8:107083520 G/T cg10147462 chr8:107024639 NA 0.51 9.27 0.46 2.49e-18 Age of smoking initiation; CRC cis rs1816752 0.870 rs9581027 chr13:24997928 G/A cg02811702 chr13:24901961 NA 0.43 5.97 0.31 5.99e-9 Obesity-related traits; CRC cis rs7937682 0.855 rs521947 chr11:111492616 A/G cg19812747 chr11:111475976 SIK2 -0.59 -10.14 -0.49 3.31e-21 Primary sclerosing cholangitis; CRC cis rs3789045 0.729 rs61817460 chr1:204543579 G/A cg17419461 chr1:204415978 PIK3C2B -0.53 -7.54 -0.38 4.61e-13 Educational attainment (college completion); CRC cis rs1552244 1.000 rs6786638 chr3:10118075 G/C cg13047869 chr3:10149882 C3orf24 0.57 7.8 0.4 8.27e-14 Alzheimer's disease; CRC cis rs763121 0.853 rs1569716 chr22:38998519 C/A cg06022373 chr22:39101656 GTPBP1 0.8 13.29 0.59 1.5e-32 Menopause (age at onset); CRC cis rs832540 0.656 rs702689 chr5:56177443 G/A cg24531977 chr5:56204891 C5orf35 -0.5 -7.21 -0.37 3.78e-12 Coronary artery disease; CRC trans rs916888 0.610 rs199442 chr17:44820122 G/A cg10053473 chr17:62856997 LRRC37A3 -0.65 -8.92 -0.44 3.39e-17 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs1552244 0.882 rs7636817 chr3:10014876 G/T cg13047869 chr3:10149882 C3orf24 0.51 6.87 0.35 3.15e-11 Alzheimer's disease; CRC cis rs1707322 0.963 rs11211202 chr1:46292382 C/T cg06784218 chr1:46089804 CCDC17 0.52 9.15 0.45 6.17e-18 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs12024301 0.557 rs6688641 chr1:183635678 A/G cg11505048 chr1:183622726 RGL1;APOBEC4 0.78 6.93 0.36 2.18e-11 Peripheral arterial disease (traffic-related air pollution interaction); CRC trans rs11654801 0.836 rs11654932 chr17:20872947 G/A cg23759823 chr7:139672531 TBXAS1 -0.38 -6.0 -0.31 5.26e-9 Mosquito bite size; CRC cis rs7772486 0.754 rs1415746 chr6:146077107 A/G cg13319975 chr6:146136371 FBXO30 0.43 6.26 0.33 1.17e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs7551222 0.749 rs6682208 chr1:204566183 T/C cg07972458 chr1:204535000 NA 0.37 5.72 0.3 2.34e-8 Schizophrenia; CRC cis rs10504229 1.000 rs17816781 chr8:58186161 A/T cg22535103 chr8:58192502 C8orf71 -0.82 -12.27 -0.56 9.63e-29 Developmental language disorder (linguistic errors); CRC cis rs11212617 0.967 rs227062 chr11:108205383 G/A cg12106634 chr11:108092400 ATM;NPAT 0.43 6.43 0.33 4.48e-10 Response to metformin in type 2 diabetes (glycemic); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg21944135 chr22:30163316 UCRC;ZMAT5 0.41 6.11 0.32 2.83e-9 Intelligence (multi-trait analysis); CRC trans rs2303319 0.504 rs72877343 chr2:162607487 A/C cg23919916 chr10:103825097 HPS6 -0.69 -6.01 -0.31 4.8e-9 Cognitive function; CRC cis rs17767392 0.958 rs61989374 chr14:71940581 A/T cg13720639 chr14:72061746 SIPA1L1 -0.56 -7.18 -0.37 4.66e-12 Mitral valve prolapse; CRC cis rs5747327 0.557 rs2895951 chr22:18232368 C/T cg13346441 chr22:18231586 BID 0.34 5.61 0.3 4.2e-8 Myeloid white cell count;Granulocyte count; CRC cis rs2239547 0.563 rs9839035 chr3:52909877 C/T cg11645453 chr3:52864694 ITIH4 0.52 9.15 0.45 5.94e-18 Schizophrenia; CRC cis rs478304 0.934 rs574483 chr11:65515277 A/G cg27068330 chr11:65405492 SIPA1 0.48 7.0 0.36 1.45e-11 Acne (severe); CRC trans rs7944735 0.507 rs7114598 chr11:48101766 C/T cg15704280 chr7:45808275 SEPT13 0.64 8.3 0.42 2.66e-15 Intraocular pressure; CRC cis rs10504229 0.679 rs7839948 chr8:58130607 A/G cg22535103 chr8:58192502 C8orf71 -0.7 -9.34 -0.46 1.47e-18 Developmental language disorder (linguistic errors); CRC cis rs728616 0.850 rs3889823 chr10:81918362 T/C cg11900509 chr10:81946545 ANXA11 -0.71 -7.34 -0.38 1.71e-12 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs11123170 0.640 rs2863240 chr2:113970116 C/T cg21610815 chr2:113994035 PAX8;LOC654433;LOC440839 -0.5 -6.51 -0.34 2.76e-10 Renal function-related traits (BUN); CRC cis rs11122272 0.735 rs2739506 chr1:231529183 T/G cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.58 -8.75 -0.43 1.1e-16 Hemoglobin concentration; CRC cis rs9372498 0.505 rs17080456 chr6:118985938 G/C cg22561889 chr6:118971681 C6orf204 0.53 6.68 0.35 1.01e-10 Diastolic blood pressure; CRC cis rs9325144 0.555 rs11183215 chr12:38693127 G/A cg13010199 chr12:38710504 ALG10B -0.45 -6.47 -0.34 3.62e-10 Morning vs. evening chronotype; CRC cis rs9400271 0.609 rs9386783 chr6:109588644 G/T cg01475377 chr6:109611718 NA -0.35 -6.09 -0.32 3.18e-9 Sum neutrophil eosinophil counts;Sum basophil neutrophil counts;White blood cell count;Neutrophil count;Myeloid white cell count;Granulocyte count; CRC cis rs7113874 0.589 rs6578969 chr11:8488991 G/A cg17679104 chr11:8615758 STK33 -0.35 -5.78 -0.3 1.71e-8 Body mass index in physically active individuals;Body mass index (joint analysis main effects and physical activity interaction); CRC trans rs11098499 0.691 rs9995716 chr4:120264996 T/C cg25214090 chr10:38739885 LOC399744 0.54 8.57 0.43 4.07e-16 Corneal astigmatism; CRC cis rs172166 0.561 rs149971 chr6:27982152 G/A cg12172441 chr6:28176163 NA 0.45 6.47 0.34 3.51e-10 Cardiac Troponin-T levels; CRC cis rs6696846 0.936 rs1042831 chr1:205043250 G/C cg00857998 chr1:205179979 DSTYK 0.44 5.97 0.31 6.18e-9 Red blood cell count; CRC cis rs3820068 0.581 rs16851819 chr1:15918739 C/T cg13390004 chr1:15929781 NA -0.5 -7.02 -0.36 1.29e-11 Systolic blood pressure; CRC trans rs2243480 0.901 rs12530490 chr7:65691647 G/A cg10756647 chr7:56101905 PSPH -0.79 -8.16 -0.41 7.21e-15 Diabetic kidney disease; CRC cis rs9322193 0.884 rs2064521 chr6:149946472 A/C cg05861140 chr6:150128134 PCMT1 0.36 5.77 0.3 1.84e-8 Lung cancer; CRC trans rs7395662 0.525 rs1945189 chr11:48418889 A/G cg21153622 chr11:89784906 NA -0.5 -8.34 -0.42 2.13e-15 HDL cholesterol; CRC cis rs8044995 0.925 rs9928653 chr16:68252079 T/C cg05110241 chr16:68378359 PRMT7 -0.44 -5.61 -0.3 4.23e-8 Schizophrenia; CRC cis rs10905065 0.965 rs10795541 chr10:5811954 A/G cg11519256 chr10:5708881 ASB13 -0.51 -7.51 -0.38 5.74e-13 Menopause (age at onset); CRC cis rs7917772 0.636 rs10786708 chr10:104526245 C/T cg04362960 chr10:104952993 NT5C2 -0.46 -6.03 -0.32 4.32e-9 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC cis rs11098499 0.779 rs7699346 chr4:120310542 C/T cg24375607 chr4:120327624 NA 0.51 7.81 0.4 7.63e-14 Corneal astigmatism; CRC trans rs7027930 0.560 rs62531538 chr9:600893 T/C cg27061366 chr19:13044373 FARSA 0.5 6.4 0.33 5.32e-10 Pulmonary function decline; CRC cis rs6964587 1.000 rs2282974 chr7:91761617 G/A cg17063962 chr7:91808500 NA 0.84 14.74 0.63 4.19e-38 Breast cancer; CRC cis rs11997175 0.574 rs7001404 chr8:33645219 G/A cg04338863 chr8:33670619 NA 0.4 6.8 0.35 5.06e-11 Body mass index; CRC cis rs394563 0.601 rs439495 chr6:149793224 A/G cg11245181 chr6:149772854 ZC3H12D 0.48 7.4 0.38 1.15e-12 Dupuytren's disease; CRC cis rs9914988 0.943 rs7211502 chr17:27163295 C/A cg07195577 chr17:27052828 TLCD1 0.41 5.81 0.31 1.45e-8 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs672059 1.000 rs544352 chr1:183157546 G/A ch.1.3577855R chr1:183094577 LAMC1 0.5 7.29 0.37 2.38e-12 Hypertriglyceridemia; CRC cis rs1005277 0.563 rs2505215 chr10:38481273 A/G cg00409905 chr10:38381863 ZNF37A -0.65 -10.65 -0.51 5.95e-23 Extrinsic epigenetic age acceleration; CRC cis rs2456568 0.802 rs7115629 chr11:93635477 G/A cg26875233 chr11:93583750 C11orf90 -0.32 -6.27 -0.33 1.11e-9 Response to serotonin reuptake inhibitors in major depressive disorder; CRC cis rs123509 0.913 rs339686 chr3:42769688 T/C cg12982090 chr3:42733453 KBTBD5 0.55 7.1 0.36 7.9e-12 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg03771878 chr16:30760186 PHKG2 0.43 6.51 0.34 2.87e-10 Intelligence (multi-trait analysis); CRC cis rs4713118 0.824 rs13211701 chr6:27750079 T/C cg20933634 chr6:27740509 NA 0.65 9.13 0.45 7.01e-18 Parkinson's disease; CRC cis rs10504229 0.953 rs17805380 chr8:58171128 C/A cg05313129 chr8:58192883 C8orf71 -0.47 -6.99 -0.36 1.49e-11 Developmental language disorder (linguistic errors); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg00989217 chr21:33651492 C21orf45 0.52 7.23 0.37 3.51e-12 Response to antipsychotic treatment; CRC cis rs1448094 0.817 rs7972773 chr12:86340774 A/C cg18827107 chr12:86230957 RASSF9 -0.43 -6.86 -0.35 3.44e-11 Major depressive disorder; CRC cis rs796364 0.951 rs12620298 chr2:201047184 C/T cg23649088 chr2:200775458 C2orf69 -0.55 -5.93 -0.31 7.46e-9 Schizophrenia; CRC cis rs11608355 0.515 rs7971160 chr12:109946751 T/A cg05360138 chr12:110035743 NA 0.77 8.66 0.43 2.14e-16 Neuroticism; CRC trans rs1005277 0.579 rs2472181 chr10:38386764 T/C cg23533926 chr12:111358616 MYL2 -0.52 -7.84 -0.4 6.17e-14 Extrinsic epigenetic age acceleration; CRC cis rs7584330 0.518 rs74003108 chr2:238448000 T/C cg14458575 chr2:238380390 NA 0.69 8.3 0.42 2.77e-15 Prostate cancer; CRC cis rs736408 0.774 rs4687551 chr3:52823448 C/T cg10802521 chr3:52805072 NEK4 0.46 6.53 0.34 2.43e-10 Bipolar disorder; CRC cis rs4481887 0.830 rs9662041 chr1:248484701 A/T cg00666640 chr1:248458726 OR2T12 0.49 8.34 0.42 2.08e-15 Common traits (Other); CRC cis rs875971 0.830 rs4718358 chr7:65973668 T/C cg11764359 chr7:65958608 NA 0.64 10.29 0.49 1.01e-21 Aortic root size; CRC cis rs8062405 1.000 rs28403629 chr16:28854769 A/G cg08761264 chr16:28874980 SH2B1 -0.44 -5.84 -0.31 1.28e-8 Cognitive ability (multi-trait analysis);Cognitive ability; CRC cis rs9916302 0.904 rs679995 chr17:37441679 A/T cg07936489 chr17:37558343 FBXL20 0.83 12.49 0.57 1.42e-29 Glomerular filtration rate (creatinine); CRC cis rs954108 0.809 rs715704 chr13:29369317 C/T cg11788234 chr13:29393811 NA -0.42 -6.62 -0.34 1.43e-10 Obesity-related traits; CRC cis rs651907 0.535 rs13094911 chr3:101519021 T/C cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.59 7.86 0.4 5.42e-14 Colorectal cancer; CRC cis rs7086627 0.515 rs11202960 chr10:82209807 G/A cg09626299 chr10:82213104 TSPAN14 -0.37 -6.23 -0.33 1.39e-9 Post bronchodilator FEV1; CRC cis rs713477 0.901 rs1572612 chr14:55909939 C/T cg13175173 chr14:55914753 NA -0.52 -9.84 -0.48 3.33e-20 Pediatric bone mineral content (femoral neck); CRC cis rs7953508 0.750 rs7310512 chr12:93976703 C/T cg18151635 chr12:93972918 NA -0.58 -8.45 -0.42 9.69e-16 Pubertal anthropometrics; CRC cis rs9916302 0.718 rs7219909 chr17:37706243 C/T cg03013999 chr17:37608204 MED1 0.47 7.3 0.37 2.19e-12 Glomerular filtration rate (creatinine); CRC cis rs889312 0.500 rs252903 chr5:56117952 A/G cg24531977 chr5:56204891 C5orf35 -0.44 -6.87 -0.35 3.18e-11 Breast cancer;Breast cancer (early onset); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg19602773 chr3:52007747 ABHD14B;ABHD14A 0.39 6.53 0.34 2.53e-10 Liver disease severity in Alagille syndrome; CRC cis rs6426558 0.537 rs10495253 chr1:227471820 A/T cg10327440 chr1:227177885 CDC42BPA 0.43 6.43 0.33 4.61e-10 Neutrophil percentage of white cells; CRC cis rs1448094 0.549 rs7297996 chr12:86235899 C/T cg25456477 chr12:86230367 RASSF9 0.36 6.23 0.32 1.46e-9 Major depressive disorder; CRC cis rs6866344 0.697 rs11739893 chr5:178127837 G/A cg10224037 chr5:178157518 ZNF354A 0.79 11.59 0.54 2.72e-26 Neutrophil percentage of white cells; CRC cis rs13256369 0.802 rs12681925 chr8:8561649 G/A cg06636001 chr8:8085503 FLJ10661 0.48 6.11 0.32 2.78e-9 Obesity-related traits; CRC cis rs2996428 0.601 rs59414187 chr1:3762815 T/C cg17848003 chr1:3704513 LRRC47 0.39 5.65 0.3 3.42e-8 Red cell distribution width; CRC cis rs2066819 1.000 rs117779516 chr12:56750872 G/C cg26714650 chr12:56694279 CS -1.45 -10.81 -0.51 1.6e-23 Psoriasis vulgaris; CRC cis rs2033711 0.840 rs10423138 chr19:58928302 T/C cg00825309 chr19:58991885 ZNF446 -0.46 -6.71 -0.35 8.75e-11 Uric acid clearance; CRC cis rs995000 0.965 rs10789113 chr1:63015199 A/T cg19896129 chr1:63156450 NA 0.4 5.83 0.31 1.29e-8 Triglyceride levels; CRC cis rs4689388 0.926 rs10937717 chr4:6295087 T/A cg00701064 chr4:6280414 WFS1 0.76 13.2 0.59 3.22e-32 Type 2 diabetes and other traits;Type 2 diabetes; CRC cis rs2204008 0.744 rs1115514 chr12:38280140 C/T cg13010199 chr12:38710504 ALG10B 0.45 6.1 0.32 2.95e-9 Bladder cancer; CRC cis rs875971 0.862 rs801204 chr7:66022921 T/C cg18876405 chr7:65276391 NA -0.52 -8.41 -0.42 1.27e-15 Aortic root size; CRC cis rs936229 0.813 rs4886619 chr15:75106138 C/T cg10253484 chr15:75165896 SCAMP2 -0.42 -6.07 -0.32 3.57e-9 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); CRC cis rs12580194 0.593 rs4590978 chr12:55725086 G/T cg19537932 chr12:55886519 OR6C68 -0.7 -8.73 -0.43 1.31e-16 Cancer; CRC cis rs4689388 0.926 rs28420833 chr4:6279504 G/A cg25554036 chr4:6271136 WFS1 0.55 8.87 0.44 4.72e-17 Type 2 diabetes and other traits;Type 2 diabetes; CRC cis rs1005224 0.889 rs9323617 chr14:76158638 A/G cg04684003 chr14:76127793 TTLL5;C14orf1 -0.49 -6.91 -0.36 2.53e-11 Large artery stroke; CRC cis rs13064411 0.696 rs6438161 chr3:113227637 G/A cg10517650 chr3:113235015 CCDC52 -0.41 -7.29 -0.37 2.4e-12 Response to simvastatin treatment (PCSK9 protein level change); CRC cis rs1008375 1.000 rs2159584 chr4:17620568 G/A cg04450456 chr4:17643702 FAM184B 0.36 5.72 0.3 2.44e-8 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs12580194 1.000 rs12580194 chr12:55696558 A/G cg19537932 chr12:55886519 OR6C68 0.61 8.44 0.42 1.01e-15 Cancer; CRC cis rs6543140 0.964 rs4851578 chr2:103028951 T/G cg09003973 chr2:102972529 NA 0.41 5.6 0.3 4.43e-8 Blood protein levels; CRC cis rs7309 0.935 rs1921309 chr2:162048975 T/A cg21518248 chr2:162101506 NA 0.45 6.64 0.34 1.3100000000000001e-10 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Educational attainment; CRC cis rs2066819 1.000 rs744051 chr12:56667298 C/T cg26714650 chr12:56694279 CS 1.41 11.64 0.54 1.88e-26 Psoriasis vulgaris; CRC cis rs7618501 0.540 rs11130241 chr3:50131459 A/T cg05623727 chr3:50126028 RBM5 -0.45 -7.38 -0.38 1.33e-12 Intelligence (multi-trait analysis); CRC cis rs3087591 1.000 rs2012988 chr17:29547296 T/C cg24425628 chr17:29625626 OMG;NF1 0.86 16.6 0.68 2.24e-45 Hip circumference; CRC cis rs853679 0.542 rs9393892 chr6:28081394 A/G cg03623178 chr6:28175578 NA 0.94 12.21 0.56 1.62e-28 Depression; CRC cis rs968567 1.000 rs968567 chr11:61595564 C/T cg00614641 chr11:61596405 FADS2 -0.54 -6.49 -0.34 3.09e-10 Blood metabolite levels;Rheumatoid arthritis;Vitiligo;Glycerophospholipid levels; CRC cis rs10504229 0.569 rs75466737 chr8:58055034 A/G cg21724239 chr8:58056113 NA 0.79 9.61 0.47 1.91e-19 Developmental language disorder (linguistic errors); CRC cis rs6952808 0.862 rs4721135 chr7:1912222 A/G cg02951883 chr7:2050386 MAD1L1 -0.58 -9.63 -0.47 1.69e-19 Bipolar disorder and schizophrenia; CRC cis rs4808199 0.948 rs1859287 chr19:19422187 T/C cg03709012 chr19:19516395 GATAD2A 0.88 11.02 0.52 3.07e-24 Nonalcoholic fatty liver disease; CRC cis rs250677 0.687 rs250666 chr5:148454622 A/G cg18129178 chr5:148520854 ABLIM3 -0.36 -5.61 -0.3 4.38e-8 Breast cancer; CRC cis rs1552244 0.554 rs6800204 chr3:9995404 A/G cg13047869 chr3:10149882 C3orf24 0.36 5.7 0.3 2.73e-8 Alzheimer's disease; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg09755102 chr1:33283495 S100PBP;YARS 0.56 7.34 0.38 1.65e-12 Thyroid stimulating hormone; CRC cis rs6866344 0.570 rs1071881 chr5:178135917 C/T cg03877680 chr5:178157825 ZNF354A 0.78 11.35 0.53 1.98e-25 Neutrophil percentage of white cells; CRC cis rs6701037 1.000 rs11585617 chr1:175123186 C/G cg00321850 chr1:175162397 KIAA0040 -0.37 -5.93 -0.31 7.86e-9 Alcohol dependence; CRC cis rs9747201 0.926 rs8065606 chr17:80063526 G/A cg14673194 chr17:80132900 CCDC57 0.48 6.24 0.33 1.36e-9 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs3099143 1.000 rs3102709 chr15:77072260 C/T cg21673338 chr15:77095150 SCAPER -0.75 -7.87 -0.4 5.12e-14 Recalcitrant atopic dermatitis; CRC cis rs12368653 0.666 rs1050045 chr12:58115271 A/G cg00677455 chr12:58241039 CTDSP2 -0.41 -5.97 -0.31 6.21e-9 Multiple sclerosis; CRC cis rs9462027 0.651 rs7752390 chr6:34790624 T/C cg07306190 chr6:34760872 UHRF1BP1 -0.34 -6.08 -0.32 3.4e-9 Systemic lupus erythematosus; CRC cis rs10744422 0.920 rs3896871 chr12:123333610 G/T cg25930673 chr12:123319894 HIP1R -0.59 -6.23 -0.32 1.42e-9 Schizophrenia; CRC cis rs12900413 0.603 rs2882677 chr15:90299514 C/T cg24249390 chr15:90295951 MESP1 -0.56 -8.95 -0.44 2.66e-17 Coronary artery aneurysm in Kawasaki disease; CRC cis rs17155006 0.746 rs435522 chr7:107748701 A/G cg05962710 chr7:107745446 LAMB4 -0.41 -7.44 -0.38 8.61e-13 Pneumococcal bacteremia; CRC cis rs34172651 0.917 rs11640931 chr16:24797919 A/G cg00339695 chr16:24857497 SLC5A11 0.26 6.01 0.31 5.01e-9 Intelligence (multi-trait analysis); CRC cis rs477692 1.000 rs506274 chr10:131409392 T/A cg05714579 chr10:131428358 MGMT 0.53 7.83 0.4 6.78e-14 Response to temozolomide; CRC cis rs10256972 0.616 rs4998392 chr7:1113344 A/C cg07308232 chr7:1071921 C7orf50 -0.47 -6.59 -0.34 1.7e-10 Longevity;Endometriosis; CRC cis rs13256369 0.708 rs10903310 chr8:8589687 A/C cg17143192 chr8:8559678 CLDN23 -0.52 -6.9 -0.36 2.75e-11 Obesity-related traits; CRC trans rs2018683 0.834 rs2012754 chr7:29026257 G/A cg19402173 chr7:128379420 CALU -0.53 -7.87 -0.4 5.26e-14 Response to irinotecan and platinum-based chemotherapy in non-small-cell lung cancer; CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg06875740 chr19:51307921 C19orf48 0.41 6.2 0.32 1.72e-9 Obesity-related traits; CRC cis rs9905704 0.914 rs34556895 chr17:56826953 G/T cg12560992 chr17:57184187 TRIM37 0.53 7.29 0.37 2.33e-12 Testicular germ cell tumor; CRC cis rs8060686 0.641 rs113790673 chr16:68244347 C/T cg26727032 chr16:67993705 SLC12A4 -0.55 -6.31 -0.33 9.13e-10 HDL cholesterol;Metabolic syndrome; CRC cis rs3741404 0.825 rs11603538 chr11:63986713 C/A cg05016508 chr11:63871570 FLRT1;MACROD1 0.44 6.62 0.34 1.47e-10 Platelet count; CRC cis rs3617 0.598 rs56214994 chr3:52878600 G/C cg18099408 chr3:52552593 STAB1 0.34 5.81 0.31 1.46e-8 Red blood cell count;Autism spectrum disorder or schizophrenia; CRC cis rs853679 0.550 rs1225599 chr6:28165190 C/T cg15786705 chr6:28176104 NA 0.81 11.69 0.54 1.25e-26 Depression; CRC cis rs9811920 0.609 rs4928232 chr3:99694217 G/A cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G -0.46 -6.19 -0.32 1.78e-9 Axial length; CRC cis rs6860806 0.507 rs273915 chr5:131660119 G/C cg18301423 chr5:131593218 PDLIM4 0.38 6.28 0.33 1.05e-9 Breast cancer; CRC cis rs62064224 0.554 rs9889352 chr17:30775761 T/C cg09324608 chr17:30823087 MYO1D 0.36 6.15 0.32 2.31e-9 Schizophrenia; CRC cis rs7617773 0.780 rs79089926 chr3:48348564 A/C cg11946769 chr3:48343235 NME6 0.73 9.71 0.47 9.45e-20 Coronary artery disease; CRC cis rs9325144 0.555 rs2387843 chr12:38711203 T/C cg13010199 chr12:38710504 ALG10B 0.41 6.08 0.32 3.27e-9 Morning vs. evening chronotype; CRC cis rs2832191 0.626 rs2254796 chr21:30341891 A/G cg08807101 chr21:30365312 RNF160 -0.71 -11.35 -0.53 2.12e-25 Dental caries; CRC cis rs7412746 0.658 rs6660845 chr1:150841066 G/A cg17724175 chr1:150552817 MCL1 0.49 7.28 0.37 2.54e-12 Melanoma; CRC cis rs2180341 0.722 rs9388555 chr6:127576363 G/A cg27446573 chr6:127587934 RNF146 0.82 12.17 0.56 2.14e-28 Breast cancer; CRC cis rs6860806 0.631 rs4705931 chr5:131588345 T/C cg18301423 chr5:131593218 PDLIM4 0.38 6.96 0.36 1.9e-11 Breast cancer; CRC cis rs9467773 0.935 rs4573 chr6:26546808 A/G cg09904177 chr6:26538194 HMGN4 0.73 11.52 0.54 5.08e-26 Intelligence (multi-trait analysis); CRC cis rs427394 0.796 rs274683 chr5:6747950 T/A cg15145174 chr5:6755386 POLS -0.4 -5.95 -0.31 7.03e-9 Menopause (age at onset); CRC cis rs2481665 0.739 rs6674622 chr1:62534938 A/G cg18591186 chr1:62594603 INADL -0.45 -6.49 -0.34 3.12e-10 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs2243480 1.000 rs781142 chr7:65438778 C/T cg12463550 chr7:65579703 CRCP 0.59 5.78 0.3 1.7e-8 Diabetic kidney disease; CRC cis rs9287719 0.967 rs3814388 chr2:10702099 A/T cg00105475 chr2:10696890 NA 0.46 7.47 0.38 7.36e-13 Prostate cancer; CRC cis rs60843830 1.000 rs62114548 chr2:274672 C/G cg00108164 chr2:264199 ACP1;SH3YL1 0.63 9.66 0.47 1.31e-19 Spherical equivalent (joint analysis main effects and education interaction); CRC cis rs6951245 0.554 rs79367977 chr7:1152657 G/A cg22907277 chr7:1156413 C7orf50 0.82 10.63 0.51 6.79e-23 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs10504229 0.639 rs16921812 chr8:58106737 C/T cg21724239 chr8:58056113 NA 0.52 6.99 0.36 1.58e-11 Developmental language disorder (linguistic errors); CRC trans rs2055729 0.885 rs13268133 chr8:9731470 C/T cg06636001 chr8:8085503 FLJ10661 0.47 6.58 0.34 1.84e-10 Multiple myeloma (hyperdiploidy); CRC cis rs17095355 1.000 rs55781439 chr10:111670220 C/T cg00817464 chr10:111662876 XPNPEP1 -0.59 -7.81 -0.4 7.98e-14 Biliary atresia; CRC cis rs6921919 0.638 rs1416920 chr6:28302784 A/G cg15845792 chr6:28175446 NA 0.49 6.55 0.34 2.19e-10 Autism spectrum disorder or schizophrenia; CRC cis rs9611565 0.559 rs132765 chr22:42008068 A/G cg06634786 chr22:41940651 POLR3H 0.62 6.51 0.34 2.84e-10 Vitiligo; CRC cis rs1799949 1.000 rs4793215 chr17:41318932 G/A cg19454999 chr17:41278357 BRCA1;NBR2 0.54 8.27 0.41 3.29e-15 Menopause (age at onset); CRC cis rs7705042 0.793 rs7705547 chr5:141514027 A/G cg08523384 chr5:141488047 NDFIP1 -0.31 -5.68 -0.3 3.02e-8 Asthma; CRC cis rs939584 0.935 rs13391851 chr2:642467 A/G cg03610516 chr2:642275 NA 0.43 5.64 0.3 3.58e-8 Body mass index; CRC cis rs7937682 0.575 rs7950926 chr11:111776437 G/C cg09085632 chr11:111637200 PPP2R1B 0.9 15.31 0.65 2.45e-40 Primary sclerosing cholangitis; CRC cis rs1799949 1.000 rs1135214 chr17:41292323 T/C cg01879757 chr17:41196368 BRCA1 -0.42 -6.24 -0.33 1.31e-9 Menopause (age at onset); CRC cis rs1552244 0.882 rs55840655 chr3:10042690 C/T cg13047869 chr3:10149882 C3orf24 0.51 6.97 0.36 1.74e-11 Alzheimer's disease; CRC trans rs7944735 0.832 rs7130876 chr11:48050995 A/G cg03929089 chr4:120376271 NA 0.58 6.2 0.32 1.68e-9 Intraocular pressure; CRC trans rs4130344 0.595 rs7697179 chr4:159863583 A/C cg04008429 chr3:160167646 TRIM59 -0.4 -5.97 -0.31 6.13e-9 Intelligence (multi-trait analysis); CRC cis rs7772486 0.686 rs2092263 chr6:146029687 G/A cg13319975 chr6:146136371 FBXO30 0.43 6.44 0.33 4.21e-10 Lobe attachment (rater-scored or self-reported); CRC cis rs11971779 0.680 rs6978680 chr7:139112048 A/G cg07862535 chr7:139043722 LUC7L2 -0.57 -7.35 -0.38 1.61e-12 Diisocyanate-induced asthma; CRC cis rs17023223 0.537 rs12087987 chr1:119734821 C/A cg05756136 chr1:119680316 WARS2 -0.53 -7.13 -0.37 6.28e-12 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for BMI in active individuals; CRC cis rs559928 0.569 rs7103915 chr11:63944370 A/G cg19465662 chr11:63993652 NUDT22;TRPT1 -0.66 -6.15 -0.32 2.21e-9 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; CRC cis rs4865169 0.934 rs3796531 chr4:57850846 A/G cg25525207 chr4:57843836 C4orf14;POLR2B 0.48 7.06 0.36 9.9e-12 Breast cancer; CRC cis rs10504229 0.906 rs113745779 chr8:58191301 C/G cg02290350 chr8:58132656 NA -0.42 -5.96 -0.31 6.62e-9 Developmental language disorder (linguistic errors); CRC cis rs9814567 1.000 rs9968172 chr3:134231251 A/G cg06109529 chr3:134205091 CEP63;ANAPC13 0.82 12.12 0.56 3.4e-28 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs651907 0.557 rs13099674 chr3:101489629 G/A cg11279151 chr3:101281821 RG9MTD1 -0.48 -6.5 -0.34 3.06e-10 Colorectal cancer; CRC cis rs17270561 0.578 rs76182885 chr6:25904085 G/C cg17691542 chr6:26056736 HIST1H1C 0.9 10.7 0.51 3.87e-23 Iron status biomarkers; CRC cis rs2243480 1.000 rs958550 chr7:65635679 C/T cg18252515 chr7:66147081 NA 1.09 12.59 0.57 6.33e-30 Diabetic kidney disease; CRC cis rs7927771 0.832 rs11605672 chr11:47413733 A/G cg18512352 chr11:47633146 NA -0.38 -7.33 -0.37 1.75e-12 Subjective well-being; CRC cis rs2985684 0.948 rs2985685 chr14:50101370 G/A cg04989706 chr14:50066350 PPIL5 -0.51 -7.17 -0.37 4.91e-12 Carotid intima media thickness; CRC cis rs78545713 0.649 rs79759076 chr6:26223694 C/G cg01420254 chr6:26195488 NA 0.66 5.87 0.31 1.04e-8 Iron status biomarkers (total iron binding capacity); CRC cis rs1577917 0.561 rs3087978 chr6:86388223 C/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A 0.52 7.41 0.38 1.09e-12 Response to antipsychotic treatment; CRC cis rs17376456 0.825 rs10054790 chr5:93272520 A/G cg25358565 chr5:93447407 FAM172A 1.12 10.53 0.5 1.51e-22 Diabetic retinopathy; CRC cis rs1862618 0.671 rs2591966 chr5:56233688 T/G cg24531977 chr5:56204891 C5orf35 0.65 10.15 0.49 3.18e-21 Initial pursuit acceleration; CRC cis rs7119 0.651 rs12902072 chr15:77848732 T/C cg10437265 chr15:77819839 NA 0.65 11.1 0.52 1.64e-24 Type 2 diabetes; CRC cis rs6951245 1.000 rs78308415 chr7:1072634 G/A cg04025307 chr7:1156635 C7orf50 0.63 6.58 0.34 1.85e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs4808199 0.895 rs12981405 chr19:19651577 C/T cg03709012 chr19:19516395 GATAD2A 1.0 11.09 0.52 1.74e-24 Nonalcoholic fatty liver disease; CRC cis rs1949733 1.000 rs2688233 chr4:8491885 T/C cg11789530 chr4:8429930 ACOX3 0.84 12.6 0.57 5.55e-30 Response to antineoplastic agents; CRC cis rs1538970 0.816 rs9727262 chr1:45998579 T/G cg05343316 chr1:45956843 TESK2 0.74 9.85 0.48 3.19e-20 Platelet count; CRC cis rs12477438 0.765 rs6754843 chr2:99680485 C/T cg26064155 chr2:99771622 LIPT1;TSGA10 -0.63 -8.55 -0.43 4.61e-16 Chronic sinus infection; CRC cis rs2932538 0.961 rs10745332 chr1:113189053 G/A cg22162597 chr1:113214053 CAPZA1 -0.69 -9.8 -0.48 4.75e-20 Systolic blood pressure;Diastolic blood pressure;Hypertension;Blood pressure; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg19089394 chr11:66610747 RCE1;C11orf80 0.48 6.57 0.34 1.93e-10 Anxiety disorder; CRC cis rs10911251 0.546 rs10911267 chr1:183115323 C/T ch.1.3577855R chr1:183094577 LAMC1 0.83 14.32 0.62 1.72e-36 Colorectal cancer; CRC cis rs7630877 0.719 rs1524514 chr3:179673066 T/C cg18765712 chr3:179670323 PEX5L 0.5 7.18 0.37 4.82e-12 Type 2 diabetes; CRC cis rs2836974 0.583 rs2735307 chr21:40713358 C/T cg17971929 chr21:40555470 PSMG1 0.52 7.29 0.37 2.29e-12 Cognitive function; CRC cis rs9902453 0.900 rs12451122 chr17:28486376 T/G cg26525008 chr17:28256777 EFCAB5;SSH2 0.59 9.17 0.45 5.44e-18 Coffee consumption (cups per day); CRC trans rs561341 0.654 rs6505265 chr17:30172580 C/T cg20587970 chr11:113659929 NA 0.82 10.15 0.49 3.13e-21 Hip circumference adjusted for BMI; CRC cis rs2227564 0.645 rs2633309 chr10:75654086 G/A cg00564723 chr10:75632066 CAMK2G -0.24 -5.71 -0.3 2.55e-8 Crohn's disease;Inflammatory bowel disease; CRC cis rs4713118 0.666 rs2893930 chr6:27738806 T/C cg15786705 chr6:28176104 NA 0.6 6.74 0.35 7.32e-11 Parkinson's disease; CRC cis rs344364 0.511 rs2982433 chr16:1954508 A/G cg09830162 chr16:1889614 FAHD1;C16orf73 -0.74 -9.49 -0.46 4.71e-19 Glomerular filtration rate in chronic kidney disease; CRC cis rs2396545 0.680 rs35467761 chr11:571568 A/G cg01842473 chr11:617407 IRF7;MUPCDH -0.5 -5.72 -0.3 2.41e-8 Systemic lupus erythematosus and Systemic sclerosis; CRC trans rs7829975 0.659 rs4382480 chr8:8721473 C/T cg16141378 chr3:129829833 LOC729375 -0.41 -6.08 -0.32 3.29e-9 Mood instability; CRC cis rs6504622 0.905 rs2317997 chr17:45027648 T/C cg16759221 chr17:45003025 GOSR2 -0.53 -8.42 -0.42 1.17e-15 Orofacial clefts; CRC cis rs8180040 0.701 rs34103310 chr3:47073266 C/T cg02527881 chr3:46936655 PTH1R -0.38 -7.05 -0.36 1.09e-11 Colorectal cancer; CRC cis rs11792861 0.816 rs28361186 chr9:111704064 G/A cg05043794 chr9:111880884 C9orf5 -0.33 -5.92 -0.31 7.88e-9 Menarche (age at onset); CRC cis rs11997175 0.740 rs4733462 chr8:33679904 A/G cg04338863 chr8:33670619 NA 0.36 5.74 0.3 2.19e-8 Body mass index; CRC cis rs2032447 0.966 rs9358901 chr6:26024436 G/T cg18357526 chr6:26021779 HIST1H4A 0.71 10.99 0.52 3.7e-24 Intelligence (multi-trait analysis); CRC cis rs524281 0.861 rs10896086 chr11:65914764 T/A cg16950941 chr11:66035639 RAB1B -0.61 -7.47 -0.38 7.43e-13 Electroencephalogram traits; CRC cis rs3750082 0.852 rs7786669 chr7:32898338 A/G cg05721444 chr7:32995514 FKBP9 0.49 7.63 0.39 2.57e-13 Glomerular filtration rate (creatinine); CRC trans rs10842750 1.000 rs10842750 chr12:26690565 G/T cg21115516 chr19:9251333 ZNF317 0.53 6.28 0.33 1.08e-9 Kashin-Beck disease; CRC cis rs4555082 0.681 rs28588570 chr14:105709606 A/T cg10792982 chr14:105748885 BRF1 0.34 5.71 0.3 2.48e-8 Mean platelet volume;Platelet distribution width; CRC cis rs9814567 0.752 rs6764764 chr3:134331167 C/T cg06109529 chr3:134205091 CEP63;ANAPC13 0.55 7.47 0.38 7.42e-13 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs9381040 0.610 rs6940462 chr6:41020223 G/A cg09580153 chr6:41068724 NFYA;LOC221442 -0.42 -6.14 -0.32 2.42e-9 Alzheimer's disease (late onset); CRC cis rs875971 1.000 rs6961155 chr7:65933295 T/C cg00343986 chr7:65444356 GUSB 0.43 6.29 0.33 1.03e-9 Aortic root size; CRC cis rs1401999 1.000 rs1533684 chr3:183635815 A/G cg20387954 chr3:183756860 HTR3D 0.44 7.36 0.38 1.47e-12 Anterior chamber depth; CRC cis rs1448094 0.556 rs4897831 chr12:86168248 C/T cg18827107 chr12:86230957 RASSF9 -0.4 -6.18 -0.32 1.89e-9 Major depressive disorder; CRC cis rs909002 0.849 rs2271933 chr1:32092525 C/T cg13919466 chr1:32135498 COL16A1 0.31 5.92 0.31 8.14e-9 Intelligence (multi-trait analysis); CRC cis rs3617 0.625 rs2535633 chr3:52859630 C/G cg11645453 chr3:52864694 ITIH4 -0.46 -9.14 -0.45 6.39e-18 Red blood cell count;Autism spectrum disorder or schizophrenia; CRC cis rs9467160 0.734 rs35901848 chr6:24443640 G/A cg20631270 chr6:24437470 GPLD1 0.5 7.08 0.36 8.98e-12 Liver enzyme levels; CRC cis rs67478160 0.643 rs7147171 chr14:104264857 G/A cg08213375 chr14:104286397 PPP1R13B 0.63 13.35 0.59 8.5e-33 Schizophrenia; CRC cis rs11190604 1.000 rs7084810 chr10:102297546 A/G cg16342193 chr10:102329863 NA -0.36 -5.99 -0.31 5.62e-9 Palmitoleic acid (16:1n-7) levels; CRC cis rs6912958 0.712 rs9444525 chr6:88324142 T/C cg12350822 chr6:88032061 C6orf162;GJB7 -0.35 -6.48 -0.34 3.37e-10 Monocyte percentage of white cells; CRC cis rs7408868 1.000 rs7254269 chr19:15277429 A/T cg14696996 chr19:15285081 NOTCH3 -0.96 -9.0 -0.44 1.82e-17 Pulse pressure; CRC cis rs877282 1.000 rs12763443 chr10:771941 G/A cg17470449 chr10:769945 NA 0.64 8.69 0.43 1.78e-16 Uric acid levels; CRC cis rs4478858 0.735 rs2271072 chr1:31840426 C/G cg00250761 chr1:31883323 NA -0.44 -8.45 -0.42 9.35e-16 Alcohol dependence; CRC cis rs8062405 0.824 rs4788084 chr16:28539848 C/T cg05139728 chr16:28306816 SBK1 -0.33 -5.63 -0.3 3.77e-8 Cognitive ability (multi-trait analysis);Cognitive ability; CRC cis rs12620999 0.941 rs10803654 chr2:238036570 C/T cg23555395 chr2:238036564 NA -0.63 -9.93 -0.48 1.71e-20 Systemic lupus erythematosus; CRC cis rs2070488 1.000 rs2268753 chr3:38500189 C/T cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.91 17.03 0.68 4.35e-47 Electrocardiographic conduction measures; CRC cis rs728616 0.614 rs17678338 chr10:82098146 C/T cg05935833 chr10:81318306 SFTPA2 -0.59 -7.26 -0.37 2.73e-12 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs1865760 0.865 rs9393677 chr6:25945815 G/A cg17691542 chr6:26056736 HIST1H1C 0.52 7.7 0.39 1.63e-13 Height; CRC cis rs9302690 0.557 rs223875 chr16:57506915 C/T cg16753122 chr16:57506917 DOK4 0.54 6.28 0.33 1.05e-9 Blood protein levels; CRC cis rs17767392 0.718 rs35609708 chr14:71843844 C/T cg13720639 chr14:72061746 SIPA1L1 -0.54 -6.77 -0.35 5.81e-11 Mitral valve prolapse; CRC cis rs12760731 0.565 rs11580064 chr1:178226520 A/G cg00404053 chr1:178313656 RASAL2 0.96 10.07 0.49 5.59e-21 Obesity-related traits; CRC trans rs2303319 0.504 rs55821334 chr2:162452014 A/G cg18122310 chr12:50236657 BCDIN3D -0.72 -6.17 -0.32 2.06e-9 Cognitive function; CRC cis rs4975616 0.804 rs457130 chr5:1336178 A/T cg06550200 chr5:1325588 CLPTM1L -0.69 -11.2 -0.53 7.13e-25 Lung cancer; CRC cis rs11148252 0.634 rs66849828 chr13:52714837 C/A cg12458913 chr13:53173898 NA 0.39 5.7 0.3 2.73e-8 Lewy body disease; CRC cis rs11212617 0.967 rs227076 chr11:108218905 T/C cg14761454 chr11:108092087 ATM;NPAT 0.42 6.34 0.33 7.54e-10 Response to metformin in type 2 diabetes (glycemic); CRC cis rs7085104 0.632 rs4290163 chr10:104610926 G/T cg04362960 chr10:104952993 NT5C2 0.57 8.33 0.42 2.24e-15 Immature fraction of reticulocytes;Schizophrenia; CRC cis rs10504229 0.728 rs72650868 chr8:58155568 G/C cg22535103 chr8:58192502 C8orf71 -0.68 -8.37 -0.42 1.72e-15 Developmental language disorder (linguistic errors); CRC trans rs559356 0.519 rs554650 chr3:34840139 G/A cg18960307 chr17:4699574 PSMB6 0.4 6.04 0.32 4.2e-9 Cognitive function; CRC cis rs10450586 0.863 rs7484147 chr11:27298126 T/C cg10370305 chr11:27303972 NA 0.38 6.11 0.32 2.86e-9 Total body bone mineral density; CRC cis rs2075371 0.863 rs12672691 chr7:133954431 C/T cg20476274 chr7:133979776 SLC35B4 0.72 12.05 0.55 6.02e-28 Mean platelet volume; CRC cis rs2404602 0.692 rs7350777 chr15:76985441 G/A cg03037974 chr15:76606532 NA 0.69 12.06 0.55 5.61e-28 Blood metabolite levels; CRC cis rs8170 0.603 rs7249329 chr19:17423373 G/T cg04749549 chr19:17459798 NA -0.44 -7.45 -0.38 8.16e-13 Breast cancer (estrogen-receptor negative);Breast Cancer in BRCA1 mutation carriers;Ovarian cancer;Breast cancer;Epithelial ovarian cancer; CRC cis rs780096 0.526 rs780102 chr2:27659491 T/C cg22903471 chr2:27725779 GCKR -0.37 -6.05 -0.32 4.04e-9 Total body bone mineral density; CRC cis rs7680126 0.596 rs35782983 chr4:10117728 G/A cg00071950 chr4:10020882 SLC2A9 -0.5 -6.28 -0.33 1.08e-9 Urate levels in lean individuals;Urate levels in overweight individuals;Urate levels in obese individuals; CRC cis rs11190604 1.000 rs6584379 chr10:102224490 G/A cg07570687 chr10:102243282 WNT8B 0.44 5.66 0.3 3.36e-8 Palmitoleic acid (16:1n-7) levels; CRC cis rs6933660 0.745 rs3800272 chr6:151744283 A/G cg14416726 chr6:151773293 C6orf211;RMND1 0.61 9.28 0.46 2.42e-18 Menarche (age at onset); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg23152667 chr5:77072348 TBCA 0.42 6.49 0.34 3.22e-10 Liver disease severity in Alagille syndrome; CRC cis rs9905704 0.918 rs9891129 chr17:56630474 T/C cg12560992 chr17:57184187 TRIM37 -0.57 -7.87 -0.4 5.06e-14 Testicular germ cell tumor; CRC cis rs651907 0.535 rs34063583 chr3:101509948 C/T cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.59 7.84 0.4 6.37e-14 Colorectal cancer; CRC cis rs7119 0.604 rs2682927 chr15:77859168 C/T cg27398640 chr15:77910606 LINGO1 0.42 7.09 0.36 8.26e-12 Type 2 diabetes; CRC cis rs3825932 0.961 rs28655102 chr15:79232700 C/T cg25744700 chr15:79237217 CTSH 0.39 5.97 0.31 6.3e-9 Type 1 diabetes; CRC cis rs62577244 0.645 rs12001733 chr9:138431675 G/T cg14582108 chr9:138439003 OBP2A 0.52 8.06 0.41 1.39e-14 Subcutaneous adipose tissue (sex interaction);Subcutaneous adipose tissue; CRC cis rs35110281 0.776 rs2838338 chr21:45075582 T/C cg01579765 chr21:45077557 HSF2BP -0.4 -7.74 -0.39 1.27e-13 Mean corpuscular volume; CRC cis rs2749592 0.725 rs9417245 chr10:37826322 C/T cg00409905 chr10:38381863 ZNF37A 0.47 6.3 0.33 9.75e-10 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs2204008 0.840 rs7136347 chr12:38453531 G/A cg13010199 chr12:38710504 ALG10B 0.47 5.99 0.31 5.57e-9 Bladder cancer; CRC cis rs7725052 0.609 rs7721742 chr5:40474477 A/G cg09067459 chr5:40385259 NA 0.4 6.57 0.34 1.94e-10 Pediatric autoimmune diseases; CRC cis rs7208859 0.573 rs73277974 chr17:29189869 A/G cg13385521 chr17:29058706 SUZ12P 0.69 8.01 0.4 2.02e-14 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs6594713 0.819 rs13180522 chr5:112726022 A/G cg12552261 chr5:112820674 MCC 0.42 5.76 0.3 1.96e-8 Brain cytoarchitecture; CRC cis rs875971 0.660 rs7807944 chr7:66087195 C/G cg18876405 chr7:65276391 NA -0.62 -11.15 -0.52 1.06e-24 Aortic root size; CRC cis rs7394190 0.748 rs12573448 chr10:75504512 T/G cg07699608 chr10:75541558 CHCHD1 0.7 6.76 0.35 6.2e-11 Incident atrial fibrillation; CRC cis rs9419702 0.568 rs7093241 chr10:133556596 G/A cg04492858 chr10:133558786 NA 0.36 5.93 0.31 7.49e-9 Survival in rectal cancer; CRC trans rs951252 0.504 rs11734405 chr4:146081096 C/T cg23486179 chr3:49466665 NICN1 0.45 6.03 0.32 4.43e-9 Hip circumference; CRC cis rs6758955 0.850 rs55638790 chr2:10480389 C/T cg15773312 chr2:10472214 HPCAL1 -0.83 -9.76 -0.47 6.34e-20 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; CRC cis rs908922 0.676 rs7531317 chr1:152528439 A/C cg23254163 chr1:152506842 NA 0.47 9.51 0.46 4.23e-19 Hair morphology; CRC cis rs2898681 0.519 rs76606067 chr4:53728221 G/T cg00791764 chr4:53727839 RASL11B 0.5 6.71 0.35 8.27e-11 Optic nerve measurement (cup area); CRC cis rs1862618 0.802 rs194058 chr5:56188977 G/A cg12311346 chr5:56204834 C5orf35 -0.83 -10.44 -0.5 3.04e-22 Initial pursuit acceleration; CRC cis rs2204008 0.775 rs2387809 chr12:38363338 T/A cg13010199 chr12:38710504 ALG10B 0.47 6.3 0.33 9.77e-10 Bladder cancer; CRC cis rs9311474 0.508 rs11720243 chr3:52618018 T/C cg11645453 chr3:52864694 ITIH4 0.36 6.41 0.33 5.03e-10 Electroencephalogram traits; CRC cis rs2204008 0.837 rs11519926 chr12:38348992 G/A cg26384229 chr12:38710491 ALG10B 0.69 9.24 0.45 3.04e-18 Bladder cancer; CRC cis rs11792861 0.816 rs28361111 chr9:111761012 A/C cg05043794 chr9:111880884 C9orf5 -0.33 -5.76 -0.3 1.88e-8 Menarche (age at onset); CRC cis rs13256369 1.000 rs10110591 chr8:8576608 G/T cg06671706 chr8:8559999 CLDN23 -0.5 -7.59 -0.39 3.31e-13 Obesity-related traits; CRC cis rs4242434 0.927 rs746011 chr8:22457804 C/T cg03733263 chr8:22462867 KIAA1967 1.04 18.28 0.71 5.3e-52 Exploratory eye movement dysfunction in schizophrenia (cognitive search score); CRC cis rs2739330 0.828 rs5751770 chr22:24252842 A/G cg10150615 chr22:24372951 LOC391322 -0.63 -9.67 -0.47 1.22e-19 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs6500602 0.893 rs4786489 chr16:4485527 G/A cg14951292 chr16:4525986 HMOX2;NMRAL1 0.58 8.41 0.42 1.28e-15 Schizophrenia; CRC cis rs7618915 0.501 rs12486554 chr3:52742537 A/T cg05573699 chr3:52720067 GNL3;PBRM1 -0.4 -5.82 -0.31 1.38e-8 Bipolar disorder; CRC cis rs11098499 0.863 rs36040693 chr4:120477616 A/G cg24375607 chr4:120327624 NA 0.48 7.19 0.37 4.29e-12 Corneal astigmatism; CRC cis rs889312 0.500 rs252903 chr5:56117952 A/G cg12311346 chr5:56204834 C5orf35 -0.44 -6.7 -0.35 9.07e-11 Breast cancer;Breast cancer (early onset); CRC cis rs1451375 0.617 rs7790758 chr7:50561544 G/A cg14593290 chr7:50529359 DDC -0.65 -8.61 -0.43 3.06e-16 Malaria; CRC trans rs7824557 0.713 rs6601575 chr8:11097804 A/C cg08975724 chr8:8085496 FLJ10661 0.41 6.16 0.32 2.16e-9 Retinal vascular caliber; CRC cis rs736408 0.812 rs2071506 chr3:52826276 T/C cg18404041 chr3:52824283 ITIH1 -0.48 -10.08 -0.49 5.44e-21 Bipolar disorder; CRC cis rs2204008 0.774 rs11495520 chr12:38060605 T/G cg13010199 chr12:38710504 ALG10B 0.44 5.64 0.3 3.74e-8 Bladder cancer; CRC cis rs10733682 0.524 rs10987422 chr9:129462687 C/A cg00232160 chr9:129468157 NA 0.34 5.78 0.3 1.76e-8 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs7552404 0.690 rs11161620 chr1:76255228 A/G cg10523679 chr1:76189770 ACADM -0.68 -8.82 -0.44 7.03e-17 Blood metabolite levels;Acylcarnitine levels; CRC cis rs734999 0.505 rs10797437 chr1:2539006 T/C cg18854424 chr1:2615690 NA 0.49 9.8 0.48 4.76e-20 Ulcerative colitis; CRC cis rs12762955 0.561 rs2620942 chr10:1048398 C/T cg19847866 chr10:1019161 NA -0.39 -5.69 -0.3 2.85e-8 Response to angiotensin II receptor blocker therapy; CRC cis rs12762955 0.561 rs2620942 chr10:1048398 C/T cg26597838 chr10:835615 NA 0.42 5.71 0.3 2.47e-8 Response to angiotensin II receptor blocker therapy; CRC cis rs11209185 0.509 rs9436789 chr1:68441456 G/A cg22082780 chr1:68452167 NA 0.39 5.82 0.31 1.44e-8 Itch intensity from mosquito bite adjusted by bite size; CRC cis rs17711722 0.522 rs4642526 chr7:65216742 G/T cg05627663 chr7:65219948 SNORA22;CCT6P1 0.63 9.76 0.47 6.16e-20 Calcium levels; CRC cis rs2281845 0.791 rs1325313 chr1:201076167 C/T cg24849736 chr1:201084428 NA 0.59 10.5 0.5 1.97e-22 Permanent tooth development; CRC cis rs10540 1.000 rs67912009 chr11:495057 G/T cg03934478 chr11:495069 RNH1 0.7 8.56 0.43 4.4e-16 Body mass index; CRC cis rs798554 0.836 rs798502 chr7:2789880 G/T cg04166393 chr7:2884313 GNA12 -0.43 -5.88 -0.31 1e-8 Height; CRC cis rs7607369 0.572 rs629177 chr2:219454801 T/G cg02176678 chr2:219576539 TTLL4 0.54 8.62 0.43 2.78e-16 Red blood cell count;Amyotrophic lateral sclerosis; CRC cis rs12477438 0.520 rs11123766 chr2:99780915 C/T cg14399236 chr2:99771627 LIPT1;TSGA10 0.81 14.32 0.62 1.66e-36 Chronic sinus infection; CRC cis rs28386778 0.863 rs6504178 chr17:61812733 A/G cg25654072 chr17:61904446 PSMC5;FTSJ3 -0.71 -11.0 -0.52 3.53e-24 Prudent dietary pattern; CRC cis rs12497850 0.931 rs12493289 chr3:48905161 G/A cg07636037 chr3:49044803 WDR6 1.02 18.52 0.71 5.84e-53 Parkinson's disease; CRC cis rs7705042 0.865 rs249643 chr5:141524746 C/G cg08523384 chr5:141488047 NDFIP1 -0.32 -5.71 -0.3 2.5e-8 Asthma; CRC trans rs2303319 0.504 rs62189043 chr2:162608466 A/T cg10498984 chr16:28874827 SH2B1 -0.73 -6.3 -0.33 9.75e-10 Cognitive function; CRC cis rs1267303 0.600 rs57100184 chr1:47004710 A/C cg08533674 chr1:46993347 NA -0.82 -10.33 -0.49 7.5e-22 Monobrow; CRC cis rs1129187 0.967 rs9462857 chr6:42943098 T/C cg02359409 chr6:42947317 PEX6 -0.58 -9.16 -0.45 5.57e-18 Alzheimer's disease in APOE e4+ carriers; CRC cis rs9303542 0.559 rs1042818 chr17:46620111 T/C cg04904318 chr17:46607828 HOXB1 -0.53 -6.12 -0.32 2.64e-9 Ovarian cancer;Epithelial ovarian cancer; CRC trans rs1455244 0.700 rs7229302 chr18:11508904 G/T cg07921184 chr16:71880281 ATXN1L 0.45 7.0 0.36 1.44e-11 Schizophrenia; CRC trans rs75246769 0.636 rs76951614 chr7:145700773 C/G cg14916917 chr5:81574294 RPS23 0.94 6.38 0.33 6.08e-10 Facial morphology (factor 10, width of nasal floor); CRC cis rs11785400 1.000 rs4557682 chr8:143738182 T/C cg10596483 chr8:143751796 JRK 0.49 6.85 0.35 3.71e-11 Schizophrenia; CRC cis rs2204008 0.837 rs12366727 chr12:38365748 A/C cg13010199 chr12:38710504 ALG10B 0.45 5.75 0.3 2e-8 Bladder cancer; CRC cis rs9818758 0.607 rs11716445 chr3:49406095 C/T cg00383909 chr3:49044727 WDR6 1.33 10.98 0.52 4.15e-24 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; CRC cis rs4917833 0.752 rs4598598 chr10:100216817 C/T cg25691326 chr10:100228212 HPSE2 0.35 5.64 0.3 3.67e-8 Pediatric bone mineral density (femoral neck); CRC cis rs4805272 0.539 rs11883172 chr19:29318536 C/T cg12756686 chr19:29218302 NA 0.49 6.52 0.34 2.61e-10 Plasma omega-3 polyunsaturated fatty acid levels (docosahexaenoic acid); CRC cis rs2732480 0.577 rs2634693 chr12:48706498 C/T cg04545296 chr12:48745243 ZNF641 0.36 6.0 0.31 5.27e-9 Hemoglobin concentration;Red blood cell count;Hematocrit; CRC cis rs926938 0.520 rs969273 chr1:115256669 G/A cg12756093 chr1:115239321 AMPD1 -0.65 -9.15 -0.45 5.97e-18 Autism; CRC cis rs1552244 0.572 rs6797536 chr3:10168802 C/T cg00166722 chr3:10149974 C3orf24 -0.66 -7.96 -0.4 2.79e-14 Alzheimer's disease; CRC cis rs4654899 0.895 rs7515590 chr1:21216664 T/C cg02927042 chr1:21476669 EIF4G3 0.42 6.74 0.35 7.06e-11 Superior frontal gyrus grey matter volume; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg06300141 chr3:32612708 DYNC1LI1 0.51 7.62 0.39 2.81e-13 Intelligence (multi-trait analysis); CRC cis rs9322193 0.962 rs10872656 chr6:150120580 A/C cg13206674 chr6:150067644 NUP43 0.56 7.97 0.4 2.71e-14 Lung cancer; CRC cis rs4665809 1.000 rs4665823 chr2:26312723 A/G cg27170947 chr2:26402098 FAM59B -0.46 -6.07 -0.32 3.59e-9 Gut microbiome composition (summer); CRC cis rs4853012 0.539 rs9789534 chr2:74362990 A/T cg01017244 chr2:74357527 NA 0.56 7.76 0.39 1.05e-13 Gestational age at birth (maternal effect); CRC cis rs1218582 0.772 rs6669791 chr1:154845484 G/T cg03351412 chr1:154909251 PMVK 0.54 8.62 0.43 2.95e-16 Prostate cancer; CRC cis rs1577917 0.740 rs9344542 chr6:86393905 C/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A 0.59 8.44 0.42 1.05e-15 Response to antipsychotic treatment; CRC cis rs10504229 0.775 rs56082079 chr8:58163732 T/C cg22535103 chr8:58192502 C8orf71 -0.72 -8.51 -0.42 6.25e-16 Developmental language disorder (linguistic errors); CRC cis rs2075371 0.933 rs1901214 chr7:133945108 C/T cg11752832 chr7:134001865 SLC35B4 -0.41 -6.26 -0.33 1.23e-9 Mean platelet volume; CRC cis rs941408 0.515 rs759067 chr19:2775668 C/T cg06609049 chr19:2785107 THOP1 1.09 18.35 0.71 2.76e-52 Total cholesterol levels; CRC cis rs910316 1.000 rs12589815 chr14:75544101 C/T cg11812906 chr14:75593930 NEK9 0.61 9.85 0.48 3.15e-20 Height; CRC cis rs6952809 1.000 rs7350030 chr7:2449157 G/A cg23289794 chr7:2394357 EIF3B -0.42 -5.71 -0.3 2.58e-8 Multiple sclerosis; CRC cis rs7412746 0.611 rs2256355 chr1:150811794 A/G cg15448220 chr1:150897856 SETDB1 0.46 6.6 0.34 1.66e-10 Melanoma; CRC cis rs13256369 0.950 rs13270006 chr8:8574197 C/A cg00074818 chr8:8560427 CLDN23 0.36 6.73 0.35 7.71e-11 Obesity-related traits; CRC cis rs1005277 0.579 rs2505237 chr10:38438898 T/G cg25517755 chr10:38738941 LOC399744 -0.42 -6.12 -0.32 2.69e-9 Extrinsic epigenetic age acceleration; CRC cis rs11971779 0.680 rs7804388 chr7:139086413 A/G cg23387468 chr7:139079360 LUC7L2 0.41 7.04 0.36 1.14e-11 Diisocyanate-induced asthma; CRC cis rs514406 0.570 rs1332776 chr1:53189816 C/T cg27535305 chr1:53392650 SCP2 -0.35 -6.46 -0.34 3.79e-10 Monocyte count; CRC trans rs875971 0.545 rs73150604 chr7:65945532 T/A cg02869306 chr7:64672164 INTS4L1 -0.42 -6.03 -0.32 4.31e-9 Aortic root size; CRC cis rs9368481 0.547 rs2093303 chr6:26864406 C/T cg18278486 chr6:26987575 LOC100270746;C6orf41 0.38 5.98 0.31 5.74e-9 Autism spectrum disorder or schizophrenia; CRC cis rs35110281 0.774 rs2838327 chr21:45018566 A/C cg01579765 chr21:45077557 HSF2BP -0.36 -6.86 -0.35 3.52e-11 Mean corpuscular volume; CRC cis rs9788333 0.707 rs12584557 chr13:21886171 C/A cg06138931 chr13:21896616 NA 0.56 9.28 0.46 2.29e-18 Thiazide-induced adverse metabolic effects in hypertensive patients; CRC cis rs853679 0.517 rs9393893 chr6:28109262 T/C cg12963246 chr6:28129442 ZNF389 0.49 5.7 0.3 2.71e-8 Depression; CRC cis rs6089584 0.586 rs1079755 chr20:60615262 G/A cg13770153 chr20:60521292 NA -0.43 -6.36 -0.33 6.82e-10 Body mass index; CRC cis rs7085104 0.700 rs10786712 chr10:104596396 A/G cg08772003 chr10:104629869 AS3MT 0.35 6.34 0.33 7.55e-10 Immature fraction of reticulocytes;Schizophrenia; CRC cis rs9326248 0.559 rs484646 chr11:116732856 A/G cg11861562 chr11:117069780 TAGLN 0.28 6.16 0.32 2.12e-9 Blood protein levels; CRC cis rs7224737 0.956 rs7208907 chr17:40284783 C/T cg00647820 chr17:40259828 DHX58 -0.46 -6.59 -0.34 1.78e-10 Fibrinogen levels; CRC cis rs8072100 0.967 rs7221548 chr17:45582952 T/C cg08085267 chr17:45401833 C17orf57 0.64 10.47 0.5 2.56e-22 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC trans rs9858542 0.953 rs6766581 chr3:49539401 T/C cg21582582 chr3:182698605 DCUN1D1 -0.51 -6.47 -0.34 3.47e-10 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs73206853 0.764 rs7960988 chr12:110749918 G/A cg12870014 chr12:110450643 ANKRD13A 0.85 10.3 0.49 9.63e-22 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC cis rs6951245 1.000 rs11763020 chr7:1060288 C/T cg04025307 chr7:1156635 C7orf50 0.66 7.04 0.36 1.13e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs10193935 0.818 rs2374428 chr2:42667961 T/C cg27598129 chr2:42591480 NA 0.63 7.62 0.39 2.76e-13 Colonoscopy-negative controls vs population controls; CRC cis rs2414095 0.520 rs3784307 chr15:51506634 G/A cg19946085 chr15:51559439 CYP19A1 -0.3 -6.11 -0.32 2.79e-9 Follicule stimulating hormone;Hormone measurements;Total body bone mineral density; CRC cis rs11098499 0.954 rs10008392 chr4:120318839 G/A cg09307838 chr4:120376055 NA 0.71 10.88 0.51 9.34e-24 Corneal astigmatism; CRC cis rs2404602 0.684 rs4886819 chr15:76901698 C/T cg03037974 chr15:76606532 NA -0.52 -7.69 -0.39 1.72e-13 Blood metabolite levels; CRC trans rs6951245 0.938 rs113642700 chr7:1105654 C/T cg13565492 chr6:43139072 SRF -0.72 -7.44 -0.38 8.72e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs13108904 0.934 rs13128045 chr4:1305309 C/T cg02018176 chr4:1364513 KIAA1530 0.46 7.44 0.38 8.6e-13 Obesity-related traits; CRC cis rs1552244 0.572 rs67227131 chr3:10172744 G/A cg16606324 chr3:10149918 C3orf24 0.65 6.77 0.35 5.81e-11 Alzheimer's disease; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg08726342 chr22:50689161 HDAC10 0.41 6.28 0.33 1.07e-9 Intelligence (multi-trait analysis); CRC cis rs294883 0.858 rs294885 chr6:159681052 T/C cg14500486 chr6:159655392 FNDC1 -0.35 -5.79 -0.3 1.66e-8 Coronary artery disease; CRC cis rs7591163 0.959 rs2396497 chr2:228724139 T/C cg14646075 chr2:228736089 WDR69 -0.43 -5.88 -0.31 1.01e-8 Blood pressure; CRC cis rs6951245 0.935 rs61910751 chr7:1097895 A/G cg22907277 chr7:1156413 C7orf50 0.73 7.68 0.39 1.78e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs66573146 0.656 rs41410847 chr4:6957332 C/T cg00086871 chr4:6988644 TBC1D14 0.87 8.62 0.43 2.91e-16 Granulocyte percentage of myeloid white cells; CRC cis rs9916302 0.707 rs11078903 chr17:37631924 G/A cg07936489 chr17:37558343 FBXL20 -0.82 -12.67 -0.57 3.17e-30 Glomerular filtration rate (creatinine); CRC cis rs1552244 1.000 rs9811771 chr3:10133949 A/G cg00166722 chr3:10149974 C3orf24 0.62 8.46 0.42 9.05e-16 Alzheimer's disease; CRC cis rs6582630 0.519 rs7305570 chr12:38349285 G/A cg13010199 chr12:38710504 ALG10B 0.47 6.3 0.33 9.67e-10 Drug-induced liver injury (flucloxacillin); CRC cis rs9534288 0.797 rs2148414 chr13:46582368 G/T cg15192986 chr13:46630673 CPB2 -0.67 -9.85 -0.48 3.16e-20 Blood protein levels; CRC cis rs9916302 0.904 rs9904334 chr17:37468336 G/A cg03013999 chr17:37608204 MED1 -0.48 -7.51 -0.38 5.62e-13 Glomerular filtration rate (creatinine); CRC cis rs1656402 0.863 rs6437069 chr2:233456647 C/T cg03852847 chr2:233439513 NA -0.41 -6.97 -0.36 1.71e-11 Non-small cell lung cancer (survival); CRC cis rs1843834 0.858 rs4674933 chr2:225514923 C/T cg22455342 chr2:225449267 CUL3 0.5 6.67 0.35 1.1e-10 IgE levels in asthmatics (D.p. specific); CRC cis rs1448094 0.512 rs6539932 chr12:86247497 T/C cg18827107 chr12:86230957 RASSF9 -0.45 -7.53 -0.38 4.88e-13 Major depressive disorder; CRC cis rs7771547 0.573 rs517890 chr6:36397786 G/C cg04289385 chr6:36355825 ETV7 0.39 5.71 0.3 2.48e-8 Platelet distribution width; CRC cis rs10504229 1.000 rs114486414 chr8:58185103 G/A cg02290350 chr8:58132656 NA -0.42 -5.96 -0.31 6.62e-9 Developmental language disorder (linguistic errors); CRC cis rs1552244 1.000 rs6414438 chr3:10073824 G/C cg10729496 chr3:10149963 C3orf24 0.49 6.6 0.34 1.7e-10 Alzheimer's disease; CRC cis rs2842992 0.915 rs2758335 chr6:160111011 G/A cg11366901 chr6:160182831 ACAT2 0.88 11.77 0.54 6.18e-27 Age-related macular degeneration (geographic atrophy); CRC trans rs4276421 0.806 rs7732970 chr5:45452146 C/T cg04793272 chr11:119020941 ABCG4 -0.38 -6.31 -0.33 9.19e-10 P wave duration; CRC trans rs34156428 0.591 rs12574491 chr11:16806473 T/A cg05563613 chr7:99070410 ZNF789 0.72 6.0 0.31 5.15e-9 Coronary artery disease; CRC trans rs1814175 0.647 rs10769646 chr11:49992204 C/A cg15704280 chr7:45808275 SEPT13 -0.94 -16.88 -0.68 1.75e-46 Height; CRC cis rs1799949 0.965 rs8176193 chr17:41231516 C/T cg19454999 chr17:41278357 BRCA1;NBR2 0.56 8.85 0.44 5.36e-17 Menopause (age at onset); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg03873659 chr3:123304056 PTPLB 0.44 6.01 0.31 4.9e-9 Response to antipsychotic treatment; CRC cis rs11105298 0.891 rs10858852 chr12:89833338 T/C cg00757033 chr12:89920650 WDR51B 0.37 6.19 0.32 1.8e-9 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; CRC cis rs4713118 0.513 rs1225591 chr6:28148752 G/A cg06470822 chr6:28175283 NA 0.83 12.2 0.56 1.72e-28 Parkinson's disease; CRC cis rs67981189 0.501 rs3829954 chr14:71455540 A/G cg15910301 chr14:71632612 NA 0.29 5.7 0.3 2.61e-8 Schizophrenia; CRC cis rs6952808 0.689 rs58227534 chr7:2046328 A/G cg18279126 chr7:2041391 MAD1L1 0.41 6.0 0.31 5.1e-9 Bipolar disorder and schizophrenia; CRC cis rs7246657 0.943 rs10405325 chr19:37883477 G/C cg23950597 chr19:37808831 NA -0.54 -6.5 -0.34 2.93e-10 Coronary artery calcification; CRC cis rs1003719 0.788 rs2835588 chr21:38462716 A/G cg10648535 chr21:38446584 PIGP;TTC3 0.52 7.29 0.37 2.32e-12 Eye color traits; CRC cis rs7107174 1.000 rs2511171 chr11:77930935 G/A cg02023728 chr11:77925099 USP35 0.49 7.24 0.37 3.29e-12 Testicular germ cell tumor; CRC cis rs57590327 0.503 rs13079104 chr3:81886039 A/T cg07356753 chr3:81810745 GBE1 -0.61 -8.37 -0.42 1.66e-15 Extraversion; CRC cis rs2067615 0.507 rs10746064 chr12:107086245 G/T cg15890332 chr12:107067104 RFX4 0.32 5.62 0.3 4.12e-8 Heart rate; CRC cis rs950776 0.714 rs17408276 chr15:78881618 T/C cg06917634 chr15:78832804 PSMA4 0.56 8.42 0.42 1.18e-15 Sudden cardiac arrest; CRC cis rs4474465 0.920 rs4474466 chr11:78204406 C/T cg27205649 chr11:78285834 NARS2 0.5 6.07 0.32 3.5e-9 Alzheimer's disease (survival time); CRC cis rs9443645 0.901 rs9352670 chr6:79584433 A/G cg09184832 chr6:79620586 NA -0.52 -9.73 -0.47 7.62e-20 Intelligence (multi-trait analysis); CRC cis rs7178572 1.000 rs12910361 chr15:77782335 A/G cg22256960 chr15:77711686 NA -0.69 -10.8 -0.51 1.8e-23 Type 2 diabetes; CRC cis rs801193 0.569 rs7800620 chr7:66223688 T/C cg00343986 chr7:65444356 GUSB 0.44 6.15 0.32 2.29e-9 Aortic root size; CRC cis rs1448094 0.817 rs10863121 chr12:86343834 A/C cg00310523 chr12:86230176 RASSF9 -0.43 -7.37 -0.38 1.39e-12 Major depressive disorder; CRC cis rs270601 0.633 rs4535443 chr5:131572561 A/G cg11843238 chr5:131593191 PDLIM4 0.54 9.66 0.47 1.36e-19 Acylcarnitine levels; CRC cis rs7605827 0.866 rs2160696 chr2:15518983 A/T cg19274914 chr2:15703543 NA 0.39 5.87 0.31 1.05e-8 Educational attainment (years of education); CRC cis rs8141529 0.748 rs7287918 chr22:29281710 G/A cg02153584 chr22:29168773 CCDC117 0.46 6.64 0.34 1.29e-10 Lymphocyte counts; CRC cis rs9381040 0.610 rs4140579 chr6:41041752 G/A cg09580153 chr6:41068724 NFYA;LOC221442 -0.41 -5.9 -0.31 9.22e-9 Alzheimer's disease (late onset); CRC cis rs477692 1.000 rs503660 chr10:131418999 A/G cg05714579 chr10:131428358 MGMT 0.52 7.76 0.39 1.09e-13 Response to temozolomide; CRC cis rs6546324 0.540 rs4671811 chr2:67827416 G/A cg15745817 chr2:67799979 NA -0.52 -8.68 -0.43 1.82e-16 Endometriosis; CRC cis rs7635838 0.827 rs9826044 chr3:11458075 A/G cg00170343 chr3:11313890 ATG7 0.41 6.24 0.33 1.35e-9 HDL cholesterol; CRC cis rs10782582 0.532 rs78106188 chr1:76137836 A/G cg10523679 chr1:76189770 ACADM -0.4 -5.73 -0.3 2.25e-8 Daytime sleep phenotypes; CRC cis rs9649213 0.614 rs4236537 chr7:97996593 T/C cg09267113 chr7:98030324 BAIAP2L1 -0.92 -12.37 -0.56 4e-29 Prostate cancer (SNP x SNP interaction); CRC trans rs7301826 0.627 rs7315707 chr12:131272819 A/G cg23334365 chr11:67806337 TCIRG1 0.48 6.26 0.33 1.23e-9 Plasma plasminogen activator levels; CRC cis rs1448094 0.791 rs7300340 chr12:86329867 G/T cg18827107 chr12:86230957 RASSF9 -0.42 -6.62 -0.34 1.48e-10 Major depressive disorder; CRC cis rs9916302 0.800 rs11869259 chr17:37518141 C/A cg15445000 chr17:37608096 MED1 -0.43 -9.66 -0.47 1.36e-19 Glomerular filtration rate (creatinine); CRC cis rs2777491 1.000 rs2730055 chr15:41735708 C/A cg18705301 chr15:41695430 NDUFAF1 -0.74 -12.68 -0.57 2.79e-30 Ulcerative colitis; CRC cis rs12476592 0.602 rs4671068 chr2:63798333 C/T cg10828910 chr2:63850056 LOC388955 0.47 6.0 0.31 5.2e-9 Childhood ear infection; CRC cis rs637571 0.522 rs550435 chr11:65732651 G/A cg17985854 chr11:65770987 BANF1;EIF1AD 0.53 8.91 0.44 3.52e-17 Eosinophil percentage of white cells; CRC cis rs7949030 0.653 rs17773169 chr11:62318530 G/T cg13298116 chr11:62369859 EML3;MTA2 0.59 10.69 0.51 4.47e-23 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; CRC cis rs7208859 0.673 rs3764421 chr17:29167653 A/C cg13385521 chr17:29058706 SUZ12P 0.69 8.01 0.4 2.06e-14 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC trans rs11039798 0.920 rs9667596 chr11:48691193 T/C cg03929089 chr4:120376271 NA 0.63 6.06 0.32 3.73e-9 Axial length; CRC trans rs2303319 0.504 rs62189055 chr2:162625749 C/A cg03774468 chr3:140950104 ACPL2 -0.66 -6.1 -0.32 3.01e-9 Cognitive function; CRC cis rs11098499 0.954 rs35091806 chr4:120325529 G/A cg09307838 chr4:120376055 NA 0.72 11.14 0.52 1.1e-24 Corneal astigmatism; CRC cis rs4332037 0.851 rs1403175 chr7:1964357 A/T cg02421172 chr7:1938701 MAD1L1 -0.42 -5.82 -0.31 1.4e-8 Bipolar disorder; CRC cis rs7927771 0.864 rs11604680 chr11:47457539 A/G cg18512352 chr11:47633146 NA -0.44 -8.5 -0.42 6.61e-16 Subjective well-being; CRC cis rs2303759 0.874 rs8108669 chr19:49845895 C/T cg24324837 chr19:49891574 CCDC155 0.57 8.18 0.41 6.38e-15 Multiple sclerosis; CRC cis rs9522267 0.535 rs56330641 chr13:112233538 C/T cg14352298 chr13:112236639 NA 0.29 6.67 0.35 1.1e-10 Hepatitis; CRC cis rs524281 0.861 rs11227411 chr11:65879478 C/T cg14036092 chr11:66035641 RAB1B -0.46 -5.62 -0.3 4.09e-8 Electroencephalogram traits; CRC cis rs1862618 0.853 rs1833896 chr5:56097669 C/A cg20203395 chr5:56204925 C5orf35 -0.59 -6.9 -0.36 2.63e-11 Initial pursuit acceleration; CRC cis rs3823572 0.542 rs2860599 chr7:133648625 C/T cg03336402 chr7:133662267 EXOC4 0.68 10.51 0.5 1.79e-22 Intelligence (multi-trait analysis); CRC cis rs2836950 0.565 rs2836930 chr21:40545656 A/G cg17971929 chr21:40555470 PSMG1 -0.6 -8.81 -0.44 7.55e-17 Menarche (age at onset); CRC cis rs1865760 0.551 rs9461230 chr6:26019240 G/C cg18357526 chr6:26021779 HIST1H4A 0.44 6.38 0.33 6.13e-10 Height; CRC cis rs3772130 0.583 rs12695415 chr3:121398853 C/T cg20356878 chr3:121714668 ILDR1 0.56 10.23 0.49 1.62e-21 Cognitive performance; CRC trans rs877282 0.898 rs12357016 chr10:765675 C/T cg22713356 chr15:30763199 NA 1.3 15.02 0.64 3.32e-39 Uric acid levels; CRC cis rs2882667 0.690 rs288024 chr5:138223792 A/G cg09476006 chr5:138032270 NA 0.55 9.14 0.45 6.76e-18 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs28386778 0.897 rs2584610 chr17:61934783 T/C cg22520471 chr17:61851767 DDX42;CCDC47 0.73 11.3 0.53 3.11e-25 Prudent dietary pattern; CRC cis rs1552244 0.816 rs13059144 chr3:10010197 A/C cg00166722 chr3:10149974 C3orf24 0.61 8.0 0.4 2.22e-14 Alzheimer's disease; CRC trans rs12478296 1.000 rs56323081 chr2:243040807 A/G cg18288967 chr1:45987694 PRDX1 0.65 7.13 0.37 6.35e-12 Obesity-related traits; CRC cis rs860295 0.702 rs3738590 chr1:155630752 A/G cg02153340 chr1:155202674 NA -0.57 -7.03 -0.36 1.2e-11 Body mass index; CRC cis rs10208940 0.777 rs35682733 chr2:68717001 G/C cg12452813 chr2:68675892 NA 0.5 6.17 0.32 2e-9 Urate levels in lean individuals; CRC cis rs4713118 0.824 rs7759217 chr6:27730463 A/G cg12172441 chr6:28176163 NA 0.55 7.14 0.37 5.96e-12 Parkinson's disease; CRC cis rs769267 0.965 rs2074303 chr19:19381755 C/T cg03709012 chr19:19516395 GATAD2A 0.72 10.98 0.52 4.29e-24 Tonsillectomy; CRC cis rs6500602 0.702 rs2058812 chr16:4524443 C/G cg14951292 chr16:4525986 HMOX2;NMRAL1 0.55 8.25 0.41 3.85e-15 Schizophrenia; CRC cis rs7618915 0.571 rs1961959 chr3:52585760 G/C cg08222913 chr3:52553049 STAB1 -0.34 -6.26 -0.33 1.23e-9 Bipolar disorder; CRC cis rs2243480 1.000 rs427044 chr7:65508545 G/A cg25985355 chr7:65971099 NA -0.53 -6.07 -0.32 3.5e-9 Diabetic kidney disease; CRC cis rs6570726 0.902 rs4895678 chr6:145935510 C/T cg23711669 chr6:146136114 FBXO30 0.69 11.2 0.53 7.2e-25 Lobe attachment (rater-scored or self-reported); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg08964912 chr20:60982779 CABLES2 0.44 6.23 0.32 1.39e-9 Response to antipsychotic treatment; CRC cis rs9318086 0.904 rs9580769 chr13:24439724 T/C cg25267304 chr13:24462978 PCOTH;MIPEP -0.59 -9.62 -0.47 1.79e-19 Myopia (pathological); CRC cis rs875971 0.965 rs9969301 chr7:65781655 G/A cg00343986 chr7:65444356 GUSB -0.43 -6.35 -0.33 7.09e-10 Aortic root size; CRC cis rs7945718 0.967 rs10831904 chr11:12760937 A/G cg25843174 chr11:12811716 TEAD1 0.49 9.11 0.45 8.26e-18 Educational attainment (years of education); CRC cis rs7726839 0.574 rs11739866 chr5:636299 C/T cg09021430 chr5:549028 NA -0.73 -8.37 -0.42 1.66e-15 Obesity-related traits; CRC cis rs7715806 0.500 rs17563700 chr5:74986045 A/G cg00601450 chr5:74908170 NA 0.49 6.12 0.32 2.71e-9 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs3736485 0.873 rs12441759 chr15:51755033 C/A cg08986416 chr15:51914746 DMXL2 -0.46 -6.65 -0.34 1.23e-10 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs5750830 0.594 rs1010169 chr22:39778167 C/T cg25459000 chr22:39777742 SYNGR1 0.36 6.55 0.34 2.22e-10 Intelligence (multi-trait analysis); CRC cis rs6693567 0.565 rs698914 chr1:150298750 A/G cg15654264 chr1:150340011 RPRD2 0.42 6.29 0.33 1.04e-9 Migraine; CRC cis rs9896052 0.591 rs7212620 chr17:73461930 A/T cg23244877 chr17:73518230 TSEN54 0.46 7.41 0.38 1.11e-12 Sight-threatening diabetic retinopathy in type 2 diabetes; CRC cis rs67311347 0.568 rs9864544 chr3:40336204 T/C cg09455208 chr3:40491958 NA 0.32 6.37 0.33 6.22e-10 Renal cell carcinoma; CRC cis rs727563 0.636 rs2187795 chr22:42092225 C/A cg06634786 chr22:41940651 POLR3H 0.63 7.15 0.37 5.78e-12 Crohn's disease;Inflammatory bowel disease; CRC cis rs1552244 1.000 rs6793396 chr3:10110927 T/C cg02579736 chr3:10068473 FANCD2;CIDECP 1.02 13.77 0.6 2.25e-34 Alzheimer's disease; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg21407906 chr20:61427925 C20orf20 0.4 6.84 0.35 3.79e-11 Liver disease severity in Alagille syndrome; CRC cis rs10751667 0.600 rs10794342 chr11:924904 C/T cg23136738 chr11:925521 AP2A2 -0.42 -6.97 -0.36 1.73e-11 Alzheimer's disease (late onset); CRC trans rs747782 0.528 rs624348 chr11:48400795 G/A cg15704280 chr7:45808275 SEPT13 -0.64 -6.27 -0.33 1.12e-9 Intraocular pressure; CRC trans rs10983614 1.000 rs7867776 chr9:120072627 A/G cg23486345 chr6:99797485 C6orf168 0.4 6.04 0.32 4.07e-9 Survival in pancreatic cancer; CRC cis rs56104184 0.887 rs4801778 chr19:49370609 G/T cg15549821 chr19:49342101 PLEKHA4 -0.6 -7.54 -0.38 4.56e-13 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; CRC cis rs3768617 0.782 rs12143211 chr1:182990172 C/G ch.1.3577855R chr1:183094577 LAMC1 0.62 9.03 0.45 1.45e-17 Fuchs's corneal dystrophy; CRC cis rs2228479 0.850 rs17226980 chr16:89825065 G/A cg06558623 chr16:89946397 TCF25 1.13 10.45 0.5 2.85e-22 Skin colour saturation; CRC cis rs6747952 0.899 rs1374387 chr2:239085687 A/C cg07480446 chr2:239069576 NA -0.37 -6.91 -0.36 2.55e-11 Mean corpuscular hemoglobin concentration; CRC cis rs9487051 0.768 rs461487 chr6:109525504 A/G cg01475377 chr6:109611718 NA -0.34 -5.98 -0.31 5.7e-9 Reticulocyte fraction of red cells; CRC cis rs6088580 0.634 rs6119497 chr20:33012529 T/A cg08999081 chr20:33150536 PIGU 0.61 11.47 0.53 7.56e-26 Glomerular filtration rate (creatinine); CRC cis rs13108904 0.840 rs3915420 chr4:1260337 T/C cg00684032 chr4:1343700 KIAA1530 0.46 6.82 0.35 4.44e-11 Obesity-related traits; CRC cis rs372883 0.600 rs407712 chr21:30722531 G/A cg08807101 chr21:30365312 RNF160 -0.58 -8.16 -0.41 7.39e-15 Pancreatic cancer; CRC trans rs1005277 0.579 rs2505196 chr10:38393563 G/A cg17830980 chr10:43048298 ZNF37B -0.6 -9.96 -0.48 1.3e-20 Extrinsic epigenetic age acceleration; CRC cis rs9916302 0.821 rs412430 chr17:37737094 C/G cg07936489 chr17:37558343 FBXL20 -0.82 -12.35 -0.56 4.71e-29 Glomerular filtration rate (creatinine); CRC cis rs6831352 0.918 rs13110176 chr4:100062430 C/T cg13256891 chr4:100009986 ADH5 0.65 8.7 0.43 1.58e-16 Alcohol dependence; CRC cis rs7267979 0.844 rs6107027 chr20:25288632 A/G cg24626310 chr20:25276739 ABHD12;PYGB 0.35 6.02 0.31 4.71e-9 Liver enzyme levels (alkaline phosphatase); CRC cis rs9902453 0.765 rs62068653 chr17:28212663 G/C cg26525008 chr17:28256777 EFCAB5;SSH2 0.66 10.58 0.5 1.03e-22 Coffee consumption (cups per day); CRC cis rs10504229 1.000 rs66840104 chr8:58190001 C/T cg05313129 chr8:58192883 C8orf71 -0.47 -6.99 -0.36 1.49e-11 Developmental language disorder (linguistic errors); CRC cis rs5750830 0.594 rs6001587 chr22:39819008 T/C cg24399712 chr22:39784796 NA -0.47 -8.86 -0.44 5.06e-17 Intelligence (multi-trait analysis); CRC cis rs10857712 0.687 rs11101742 chr10:135224372 C/G cg19904058 chr10:135279010 LOC619207 -0.28 -5.65 -0.3 3.48e-8 Systemic lupus erythematosus; CRC cis rs12477438 0.834 rs10179043 chr2:99687490 T/C cg26064155 chr2:99771622 LIPT1;TSGA10 -0.76 -10.68 -0.51 4.78e-23 Chronic sinus infection; CRC trans rs56114371 0.777 rs200481 chr6:27773832 A/T cg06606381 chr12:133084897 FBRSL1 -0.7 -6.32 -0.33 8.54e-10 Breast cancer; CRC trans rs10982213 0.830 rs2274163 chr9:117188714 C/T cg24730871 chr19:19516902 GATAD2A 0.39 6.39 0.33 5.82e-10 Interleukin-6 levels; CRC cis rs644799 1.000 rs3748256 chr11:95521953 A/G cg25622487 chr11:95524042 FAM76B;CEP57 0.75 11.76 0.54 6.56e-27 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs7493 0.853 rs6973380 chr7:95043523 C/T cg19678392 chr7:94953810 PON1 -0.56 -7.24 -0.37 3.3e-12 Yu-Zhi constitution type in type 2 diabetes; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg13557688 chr9:119449590 ASTN2;TRIM32 0.38 6.27 0.33 1.15e-9 Liver disease severity in Alagille syndrome; CRC cis rs2842992 0.830 rs2273819 chr6:160183325 G/C cg11366901 chr6:160182831 ACAT2 0.98 14.41 0.62 7.9e-37 Age-related macular degeneration (geographic atrophy); CRC trans rs61931739 0.534 rs11053016 chr12:34104372 C/T cg26384229 chr12:38710491 ALG10B 0.54 6.95 0.36 1.99e-11 Morning vs. evening chronotype; CRC cis rs727563 0.636 rs2187795 chr22:42092225 C/A cg03806693 chr22:41940476 POLR3H 1.06 13.33 0.59 1.06e-32 Crohn's disease;Inflammatory bowel disease; CRC cis rs8005677 1.000 rs7155857 chr14:23400059 C/A cg01529538 chr14:23388837 RBM23 0.39 6.02 0.32 4.56e-9 Cognitive ability (multi-trait analysis); CRC cis rs7615952 0.599 rs6779141 chr3:125709995 A/T cg05084668 chr3:125655381 ALG1L -0.46 -6.6 -0.34 1.64e-10 Blood pressure (smoking interaction); CRC cis rs1532331 0.865 rs6862639 chr5:43166254 A/G cg09164108 chr5:43007320 NA 0.38 5.89 0.31 9.72e-9 Menarche (age at onset); CRC cis rs17227506 0.679 rs67768235 chr8:13443286 T/C cg03566418 chr8:13424080 C8orf48 0.35 5.92 0.31 7.94e-9 Nonsyndromic cleft lip with cleft palate; CRC cis rs9549367 0.713 rs4907599 chr13:113861441 C/T cg18105134 chr13:113819100 PROZ 0.84 13.44 0.6 3.95e-33 Platelet distribution width; CRC cis rs1572438 0.760 rs7740748 chr6:869509 T/C cg21062780 chr6:887772 NA -0.38 -5.98 -0.31 5.78e-9 Aging; CRC cis rs28386778 0.897 rs2584610 chr17:61934783 T/C cg25654072 chr17:61904446 PSMC5;FTSJ3 0.71 10.95 0.52 5.46e-24 Prudent dietary pattern; CRC cis rs13191362 1.000 rs66789102 chr6:163104432 T/C cg21926612 chr6:163149169 PACRG;PARK2 0.98 12.74 0.57 1.77e-30 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs10540 0.570 rs8176330 chr11:535798 G/A cg03576123 chr11:487126 PTDSS2 -1.0 -10.1 -0.49 4.63e-21 Body mass index; CRC cis rs9649213 0.593 rs2158553 chr7:97951131 G/A cg21770322 chr7:97807741 LMTK2 0.51 8.29 0.42 2.89e-15 Prostate cancer (SNP x SNP interaction); CRC cis rs7927771 0.965 rs34958982 chr11:47547046 T/C cg05585544 chr11:47624801 NA -0.62 -11.39 -0.53 1.48e-25 Subjective well-being; CRC cis rs9902453 0.689 rs56788338 chr17:28186557 C/T cg26525008 chr17:28256777 EFCAB5;SSH2 0.65 10.55 0.5 1.31e-22 Coffee consumption (cups per day); CRC cis rs8180040 0.654 rs6766230 chr3:47196209 C/A cg10298567 chr3:47292165 KIF9 -0.4 -6.25 -0.33 1.3e-9 Colorectal cancer; CRC cis rs10504229 0.635 rs72649130 chr8:58053810 G/T cg02725872 chr8:58115012 NA -0.56 -7.62 -0.39 2.74e-13 Developmental language disorder (linguistic errors); CRC cis rs13108904 0.935 rs3755920 chr4:1243617 T/C cg21620606 chr4:1342894 KIAA1530 0.37 6.4 0.33 5.37e-10 Obesity-related traits; CRC cis rs10479542 0.896 rs4701130 chr5:178982416 C/T cg22764044 chr5:178986830 RUFY1 -0.42 -7.38 -0.38 1.29e-12 Lung cancer; CRC cis rs9443645 0.803 rs1547731 chr6:79776104 A/G cg05283184 chr6:79620031 NA -0.6 -9.47 -0.46 5.53e-19 Intelligence (multi-trait analysis); CRC cis rs9902453 0.838 rs7217638 chr17:28336772 T/C cg26525008 chr17:28256777 EFCAB5;SSH2 -0.59 -8.78 -0.44 8.99e-17 Coffee consumption (cups per day); CRC cis rs3785574 1.000 rs7223257 chr17:61787684 T/C cg22520471 chr17:61851767 DDX42;CCDC47 0.45 6.22 0.32 1.48e-9 Height; CRC cis rs9039 1.000 rs56193985 chr16:9207199 C/A cg08831531 chr16:9218945 NA -0.46 -5.93 -0.31 7.59e-9 Menopause (age at onset); CRC cis rs644799 0.710 rs3017756 chr11:95537358 G/A cg25622487 chr11:95524042 FAM76B;CEP57 0.8 13.52 0.6 2.03e-33 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs4588572 0.537 rs7719228 chr5:77730576 G/A cg11547950 chr5:77652471 NA -0.49 -7.08 -0.36 9e-12 Triglycerides; CRC cis rs7626444 0.625 rs843531 chr3:196481771 T/C cg12930392 chr3:196481615 PAK2 0.39 7.11 0.36 7.25e-12 Monocyte count; CRC cis rs2462686 1.000 rs2965071 chr7:46001382 T/A cg23193639 chr7:45961078 IGFBP3 0.37 5.72 0.3 2.37e-8 Major depressive disorder; CRC cis rs853679 0.517 rs9357065 chr6:28129580 T/C cg02683197 chr6:28174875 NA 0.88 10.7 0.51 3.93e-23 Depression; CRC cis rs9487051 0.872 rs9400271 chr6:109607556 G/A cg12927641 chr6:109611667 NA -0.37 -6.75 -0.35 6.5e-11 Reticulocyte fraction of red cells; CRC cis rs8067545 0.611 rs16960697 chr17:20027718 A/G cg13482628 chr17:19912719 NA 0.44 6.92 0.36 2.34e-11 Schizophrenia; CRC cis rs364477 0.904 rs279905 chr9:959821 T/C cg13952963 chr9:998547 NA 0.55 5.88 0.31 9.89e-9 Major depressive disorder; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg19260500 chr3:133969278 RYK 0.43 6.05 0.32 3.92e-9 Anxiety disorder; CRC cis rs6570726 0.791 rs365869 chr6:145884751 C/T cg05347473 chr6:146136440 FBXO30 0.41 6.15 0.32 2.19e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs3733585 0.605 rs4697708 chr4:10121189 A/G cg11266682 chr4:10021025 SLC2A9 -0.49 -9.15 -0.45 6.36e-18 Cleft plate (environmental tobacco smoke interaction); CRC cis rs7725052 0.609 rs61422440 chr5:40447157 G/A cg09067459 chr5:40385259 NA -0.44 -7.23 -0.37 3.46e-12 Pediatric autoimmune diseases; CRC cis rs6960043 0.818 rs10244051 chr7:15063833 T/G cg19272540 chr7:15055459 NA -0.22 -5.94 -0.31 7.15e-9 Type 2 diabetes; CRC cis rs4555082 0.718 rs75139030 chr14:105710853 A/AG cg13114125 chr14:105738426 BRF1 -0.82 -11.97 -0.55 1.2e-27 Mean platelet volume;Platelet distribution width; CRC cis rs7246657 0.943 rs7255972 chr19:37933841 T/C cg23950597 chr19:37808831 NA -0.54 -6.51 -0.34 2.82e-10 Coronary artery calcification; CRC cis rs7412746 0.611 rs9661876 chr1:150910911 C/T cg15448220 chr1:150897856 SETDB1 0.46 6.84 0.35 3.98e-11 Melanoma; CRC cis rs10504229 0.593 rs76922080 chr8:57985837 C/G cg08219700 chr8:58056026 NA 0.56 6.45 0.34 3.97e-10 Developmental language disorder (linguistic errors); CRC cis rs765787 0.530 rs16941017 chr15:45543281 T/C cg24006582 chr15:45444508 DUOX1 -0.57 -8.58 -0.43 3.94e-16 Uric acid levels; CRC cis rs7914558 0.933 rs12763665 chr10:104653717 G/A cg15744005 chr10:104629667 AS3MT -0.33 -7.19 -0.37 4.36e-12 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs294883 0.739 rs962339 chr6:159729165 G/T cg14500486 chr6:159655392 FNDC1 -0.36 -6.19 -0.32 1.81e-9 Coronary artery disease; CRC cis rs3751196 0.901 rs55987022 chr12:104205100 G/C cg02344784 chr12:104178138 NT5DC3 0.69 6.98 0.36 1.62e-11 Sense of smell; CRC cis rs2836974 0.932 rs6517527 chr21:40581751 G/A cg17971929 chr21:40555470 PSMG1 0.83 11.93 0.55 1.67e-27 Cognitive function; CRC cis rs1865760 0.602 rs9467662 chr6:26021327 G/A cg16482183 chr6:26056742 HIST1H1C 0.53 7.79 0.39 9.12e-14 Height; CRC cis rs11122272 0.668 rs2472261 chr1:231505701 G/A cg06096015 chr1:231504339 EGLN1 0.41 6.11 0.32 2.79e-9 Hemoglobin concentration; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg05243909 chr16:2097910 NTHL1;TSC2 0.49 6.23 0.32 1.46e-9 Thyroid stimulating hormone; CRC cis rs2404602 0.647 rs12914196 chr15:76941361 C/T cg23625390 chr15:77176239 SCAPER -0.86 -13.34 -0.59 9.63e-33 Blood metabolite levels; CRC cis rs10484885 0.887 rs2273246 chr6:90453263 A/G cg13799429 chr6:90582589 CASP8AP2 -0.77 -10.0 -0.48 1.01e-20 QRS interval (sulfonylurea treatment interaction); CRC cis rs3858526 0.959 rs11039723 chr11:5956002 G/C cg05234568 chr11:5960015 NA -0.62 -8.24 -0.41 4.14e-15 DNA methylation (variation); CRC cis rs4891159 0.790 rs683306 chr18:74112473 C/G cg24786174 chr18:74118243 ZNF516 -0.91 -17.15 -0.69 1.5e-47 Longevity; CRC cis rs2274273 0.967 rs1009978 chr14:55603061 C/G cg23234261 chr14:55582407 NA -0.29 -5.72 -0.3 2.39e-8 Protein biomarker; CRC cis rs12971120 0.947 rs4891559 chr18:72170397 C/T cg25817165 chr18:72167213 CNDP2 -0.64 -12.13 -0.56 3.04e-28 Refractive error; CRC cis rs4148883 0.689 rs1311621 chr4:100014018 T/C cg12011299 chr4:100065546 ADH4 0.53 11.82 0.55 4.25e-27 Alcohol dependence; CRC cis rs7605827 0.897 rs11901455 chr2:15623888 C/T cg19274914 chr2:15703543 NA 0.38 5.8 0.3 1.57e-8 Educational attainment (years of education); CRC cis rs614226 1.000 rs541126 chr12:120972396 C/T cg27489772 chr12:121021490 NA -0.49 -6.6 -0.34 1.62e-10 Type 1 diabetes nephropathy; CRC cis rs7584330 0.518 rs11888077 chr2:238424763 G/A cg08992911 chr2:238395768 MLPH 0.65 6.52 0.34 2.69e-10 Prostate cancer; CRC cis rs3751196 0.808 rs61512578 chr12:104218838 C/G cg02344784 chr12:104178138 NT5DC3 0.71 7.55 0.38 4.35e-13 Sense of smell; CRC cis rs9640161 0.789 rs3735172 chr7:150028958 C/T cg12556325 chr7:150026731 C7orf29;LRRC61 0.4 6.4 0.33 5.35e-10 Blood protein levels;Circulating chemerin levels; CRC cis rs7224737 1.000 rs739637 chr17:40280944 G/C cg02228675 chr17:40259724 DHX58 -0.5 -7.01 -0.36 1.38e-11 Fibrinogen levels; CRC cis rs2204008 0.748 rs11180579 chr12:38237830 A/G cg13010199 chr12:38710504 ALG10B 0.46 5.83 0.31 1.31e-8 Bladder cancer; CRC cis rs9462027 0.540 rs2814951 chr6:34695081 C/T cg07306190 chr6:34760872 UHRF1BP1 -0.34 -6.07 -0.32 3.49e-9 Systemic lupus erythematosus; CRC cis rs6860806 0.507 rs635619 chr5:131720265 G/A cg04518342 chr5:131593106 PDLIM4 -0.44 -7.18 -0.37 4.77e-12 Breast cancer; CRC cis rs72717009 0.825 rs7552317 chr1:161479438 C/T cg10431340 chr1:161279108 MPZ -0.5 -6.82 -0.35 4.4e-11 Rheumatoid arthritis; CRC cis rs2153535 0.580 rs9405390 chr6:8466209 T/G cg21535247 chr6:8435926 SLC35B3 0.5 7.53 0.38 4.89e-13 Motion sickness; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg08030210 chr19:10362462 MRPL4 0.48 6.08 0.32 3.33e-9 Thyroid stimulating hormone; CRC cis rs4654899 0.897 rs10916856 chr1:21082074 A/C cg02927042 chr1:21476669 EIF4G3 -0.43 -6.69 -0.35 9.37e-11 Superior frontal gyrus grey matter volume; CRC cis rs11122272 0.735 rs2486740 chr1:231517552 T/C cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.54 -8.09 -0.41 1.18e-14 Hemoglobin concentration; CRC cis rs2836974 0.568 rs2142111 chr21:40549289 G/C cg06238570 chr21:40685208 BRWD1 0.83 13.29 0.59 1.53e-32 Cognitive function; CRC cis rs7615952 0.599 rs6438953 chr3:125724951 T/C cg02772935 chr3:125709198 NA -0.46 -5.98 -0.31 5.91e-9 Blood pressure (smoking interaction); CRC cis rs2976388 0.609 rs2263092 chr8:143789966 A/G cg04969067 chr8:143858791 LYNX1 0.45 7.59 0.39 3.26e-13 Urinary tract infection frequency; CRC cis rs9527 0.590 rs11191547 chr10:104843148 C/T cg04362960 chr10:104952993 NT5C2 0.58 8.17 0.41 6.8e-15 Arsenic metabolism; CRC trans rs1814175 0.817 rs10769648 chr11:50013992 T/C cg15704280 chr7:45808275 SEPT13 -0.99 -20.61 -0.75 3.6e-61 Height; CRC cis rs8177253 0.665 rs9869257 chr3:133451412 G/T cg17775713 chr3:133465469 TF 0.33 5.85 0.31 1.19e-8 Iron status biomarkers; CRC cis rs2880765 0.677 rs7181410 chr15:86006335 A/G cg17133734 chr15:86042851 AKAP13 -0.4 -6.34 -0.33 7.43e-10 Coronary artery disease; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg02767759 chr16:30366751 CD2BP2 0.46 5.99 0.31 5.53e-9 Thyroid stimulating hormone; CRC cis rs425277 0.606 rs2257182 chr1:2082566 C/T cg04315214 chr1:2043799 PRKCZ 0.34 6.09 0.32 3.1e-9 Height; CRC cis rs13108904 0.870 rs11721789 chr4:1254414 C/A cg05665937 chr4:1216051 CTBP1 0.43 6.44 0.33 4.34e-10 Obesity-related traits; CRC cis rs9976767 0.896 rs9975920 chr21:43818656 A/G cg23042151 chr21:43824109 UBASH3A -0.37 -6.57 -0.34 1.99e-10 Type 1 diabetes; CRC cis rs9393692 0.676 rs1543681 chr6:26187783 G/T cg13736514 chr6:26305472 NA -0.54 -9.72 -0.47 8.63e-20 Educational attainment; CRC cis rs10540 1.000 rs12418639 chr11:473300 A/C cg08200582 chr11:442649 ANO9 0.64 6.54 0.34 2.32e-10 Body mass index; CRC cis rs55665837 0.524 rs2882128 chr11:14414634 A/C cg05501817 chr11:14380813 RRAS2 -0.43 -5.85 -0.31 1.16e-8 Vitamin D levels; CRC cis rs8114671 0.562 rs6120763 chr20:33506400 C/G cg07148914 chr20:33460835 GGT7 0.39 6.33 0.33 8.21e-10 Height; CRC cis rs9902453 0.904 rs4461132 chr17:28423430 A/G cg26525008 chr17:28256777 EFCAB5;SSH2 0.72 12.03 0.55 6.96e-28 Coffee consumption (cups per day); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg00805381 chr6:24720818 C6orf62 0.43 6.3 0.33 9.48e-10 Intelligence (multi-trait analysis); CRC cis rs10992471 0.528 rs4744135 chr9:95251874 A/C cg14631576 chr9:95140430 CENPP 0.31 5.76 0.3 1.96e-8 Visceral adipose tissue/subcutaneous adipose tissue ratio; CRC cis rs2730260 0.736 rs7784586 chr7:158836379 T/C cg02254261 chr7:158964346 NA -0.52 -6.21 -0.32 1.57e-9 Myopia (pathological); CRC cis rs13108904 0.967 rs13149715 chr4:1278255 C/A cg02018176 chr4:1364513 KIAA1530 0.48 7.93 0.4 3.43e-14 Obesity-related traits; CRC cis rs10504229 0.517 rs75486476 chr8:58056079 G/T cg22535103 chr8:58192502 C8orf71 -0.48 -6.95 -0.36 1.93e-11 Developmental language disorder (linguistic errors); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg19243130 chr11:124543550 SIAE;SPA17 0.37 6.09 0.32 3.17e-9 Liver disease severity in Alagille syndrome; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg17840164 chr10:104262570 SUFU;ACTR1A 0.44 6.13 0.32 2.45e-9 Response to antipsychotic treatment; CRC cis rs3617 0.573 rs9860296 chr3:52913781 A/G cg15147215 chr3:52552868 STAB1 -0.42 -6.88 -0.35 2.96e-11 Red blood cell count;Autism spectrum disorder or schizophrenia; CRC cis rs9486719 0.843 rs3849198 chr6:97036539 C/A cg18709589 chr6:96969512 KIAA0776 -0.52 -5.83 -0.31 1.3e-8 Migraine;Coronary artery disease; CRC cis rs763121 0.853 rs6001214 chr22:39149155 C/T cg06544989 chr22:39130855 UNC84B 0.47 6.98 0.36 1.69e-11 Menopause (age at onset); CRC cis rs7923609 0.967 rs3740331 chr10:65192288 G/A cg08743896 chr10:65200160 JMJD1C -0.42 -6.12 -0.32 2.62e-9 Educational attainment;Liver enzyme levels (alkaline phosphatase); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg14843902 chr17:47492407 PHB 0.37 6.24 0.33 1.36e-9 Liver disease severity in Alagille syndrome; CRC cis rs6570726 0.935 rs7757387 chr6:145816726 G/T cg23711669 chr6:146136114 FBXO30 0.62 10.62 0.51 7.79e-23 Lobe attachment (rater-scored or self-reported); CRC trans rs9329221 0.905 rs4610752 chr8:10248962 A/G cg06636001 chr8:8085503 FLJ10661 -0.56 -8.88 -0.44 4.39e-17 Neuroticism; CRC cis rs365302 1.000 rs378194 chr6:159646323 C/T cg14500486 chr6:159655392 FNDC1 0.43 6.59 0.34 1.76e-10 Coronary heart disease; CRC cis rs1865760 0.566 rs9379821 chr6:26054268 A/C cg17691542 chr6:26056736 HIST1H1C 0.55 8.28 0.42 3.14e-15 Height; CRC cis rs10782582 0.593 rs12130832 chr1:76234294 T/C cg05598546 chr1:76251766 SNORD45C;RABGGTB 0.44 5.79 0.3 1.63e-8 Daytime sleep phenotypes; CRC cis rs17711722 0.510 rs11767457 chr7:65290615 C/T cg05627663 chr7:65219948 SNORA22;CCT6P1 0.68 10.35 0.5 6.36e-22 Calcium levels; CRC cis rs17666538 0.792 rs7820788 chr8:601846 C/T cg26554054 chr8:600488 NA 0.7 6.91 0.36 2.51e-11 IgG glycosylation; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg13244110 chr17:40688572 NAGLU 0.46 6.45 0.34 3.93e-10 Response to antipsychotic treatment; CRC cis rs2404602 0.684 rs157759 chr15:76846990 T/A cg23625390 chr15:77176239 SCAPER 0.78 12.62 0.57 4.87e-30 Blood metabolite levels; CRC cis rs9399135 0.967 rs9321481 chr6:135352648 C/G cg22676075 chr6:135203613 NA -0.38 -5.75 -0.3 2.06e-8 Red blood cell count; CRC cis rs919433 1.000 rs1429414 chr2:198162430 C/T cg10820045 chr2:198174542 NA -0.54 -10.2 -0.49 2.08e-21 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC cis rs6089584 0.888 rs2386555 chr20:60612373 C/T cg23262073 chr20:60523788 NA -0.46 -7.17 -0.37 5.07e-12 Body mass index; CRC cis rs1552244 1.000 rs76041173 chr3:10078695 G/T cg10729496 chr3:10149963 C3orf24 0.55 7.12 0.37 6.94e-12 Alzheimer's disease; CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg13099106 chr12:120525172 CCDC64 -0.49 -6.17 -0.32 2.03e-9 Diisocyanate-induced asthma; CRC cis rs7259376 0.623 rs12610063 chr19:22493057 C/T cg02657401 chr19:22469223 NA -0.31 -6.8 -0.35 4.97e-11 Menopause (age at onset); CRC cis rs12042938 0.507 rs1655301 chr1:231731730 T/C cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.61 -9.24 -0.45 3.2e-18 Neuranatomic and neurocognitive phenotypes; CRC cis rs7224737 1.000 rs12603327 chr17:40290552 T/C cg02228675 chr17:40259724 DHX58 -0.48 -6.8 -0.35 5.05e-11 Fibrinogen levels; CRC cis rs4665809 0.759 rs62128394 chr2:26364026 T/G cg25036284 chr2:26402008 FAM59B 0.62 6.69 0.35 9.7e-11 Gut microbiome composition (summer); CRC cis rs514406 0.505 rs6703127 chr1:53180565 C/T cg25767906 chr1:53392781 SCP2 -0.39 -6.02 -0.32 4.65e-9 Monocyte count; CRC cis rs9902453 0.967 rs8082175 chr17:28430303 C/A cg26525008 chr17:28256777 EFCAB5;SSH2 0.59 8.92 0.44 3.23e-17 Coffee consumption (cups per day); CRC cis rs7107770 1.000 rs34457642 chr11:125086200 A/T cg27629782 chr11:125073726 PKNOX2 0.51 6.21 0.32 1.57e-9 Photic sneeze reflex; CRC cis rs12472274 0.646 rs34989058 chr2:239074698 C/T cg17459225 chr2:239074497 NA 0.68 8.13 0.41 9.13e-15 Phospholipid levels (plasma); CRC cis rs4713118 0.516 rs6931858 chr6:28078411 A/T cg12172441 chr6:28176163 NA 0.58 6.78 0.35 5.72e-11 Parkinson's disease; CRC cis rs7247513 0.759 rs8110545 chr19:12754898 C/T cg11738485 chr19:12877000 HOOK2 0.39 5.69 0.3 2.75e-8 Bipolar disorder; CRC cis rs2456568 0.803 rs10831140 chr11:93640689 G/A cg26875233 chr11:93583750 C11orf90 -0.31 -6.02 -0.32 4.6e-9 Response to serotonin reuptake inhibitors in major depressive disorder; CRC cis rs9399135 1.000 rs4895435 chr6:135293463 C/A cg24558204 chr6:135376177 HBS1L 0.47 7.2 0.37 4e-12 Red blood cell count; CRC cis rs7617773 0.710 rs36064160 chr3:48243101 C/G cg11946769 chr3:48343235 NME6 0.73 9.72 0.47 8.56e-20 Coronary artery disease; CRC cis rs12024301 0.557 rs7517010 chr1:183594728 C/G cg11505048 chr1:183622726 RGL1;APOBEC4 0.76 6.93 0.36 2.16e-11 Peripheral arterial disease (traffic-related air pollution interaction); CRC trans rs61931739 0.517 rs11611190 chr12:34015697 G/A cg26384229 chr12:38710491 ALG10B 0.54 6.9 0.36 2.76e-11 Morning vs. evening chronotype; CRC trans rs1642645 0.831 rs2042064 chr1:42491429 C/T cg16926213 chr1:1841314 NA -0.43 -6.11 -0.32 2.74e-9 Left ventricular obstructive tract defect (maternal effect); CRC trans rs7821565 0.904 rs1370444 chr8:52164298 G/A cg09187163 chr7:72721838 NSUN5 -0.41 -5.98 -0.31 5.79e-9 Tuberculosis; CRC cis rs8177253 1.000 rs8177272 chr3:133482870 C/T cg24879335 chr3:133465180 TF 0.31 5.76 0.3 1.95e-8 Iron status biomarkers; CRC cis rs2551802 0.615 rs17395735 chr2:177067780 C/T cg13092806 chr2:177043255 NA 0.53 7.14 0.37 6.1e-12 Motion sickness; CRC cis rs7586879 0.796 rs916484 chr2:25082588 A/C cg04586622 chr2:25135609 ADCY3 -0.54 -9.2 -0.45 4.19e-18 Body mass index; CRC cis rs11105298 0.891 rs10858894 chr12:89914261 T/C cg08166232 chr12:89918718 WDR51B;GALNT4 -0.63 -7.88 -0.4 4.75e-14 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; CRC cis rs9487051 0.872 rs1111864 chr6:109611138 A/G cg01475377 chr6:109611718 NA -0.49 -9.26 -0.45 2.75e-18 Reticulocyte fraction of red cells; CRC trans rs1973993 0.934 rs588660 chr1:96886604 G/A cg10631902 chr5:14652156 NA 0.52 9.17 0.45 5.35e-18 Weight; CRC cis rs3793683 0.556 rs2803989 chr10:134560596 C/T cg18305652 chr10:134549665 INPP5A 0.4 5.8 0.3 1.54e-8 Migraine; CRC cis rs9902453 0.868 rs9896012 chr17:28470091 T/C cg26525008 chr17:28256777 EFCAB5;SSH2 0.68 11.1 0.52 1.55e-24 Coffee consumption (cups per day); CRC cis rs9911578 0.874 rs302865 chr17:56756977 A/G cg12560992 chr17:57184187 TRIM37 0.85 15.09 0.64 1.79e-39 Intelligence (multi-trait analysis); CRC cis rs3741151 0.686 rs1938777 chr11:73122340 A/G cg17517138 chr11:73019481 ARHGEF17 0.53 5.75 0.3 2.09e-8 GIP levels in response to oral glucose tolerance test (120 minutes); CRC cis rs703970 0.522 rs2802363 chr10:80988837 A/G cg20744163 chr10:80999841 ZMIZ1 -0.37 -6.34 -0.33 7.41e-10 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs11971779 0.941 rs7802779 chr7:139122579 G/T cg07862535 chr7:139043722 LUC7L2 0.75 9.08 0.45 1e-17 Diisocyanate-induced asthma; CRC cis rs727505 0.754 rs55859595 chr7:124783083 G/T cg23710748 chr7:124431027 NA -0.67 -11.43 -0.53 1.04e-25 Lewy body disease; CRC cis rs2070997 0.617 rs3808816 chr9:133746117 C/T cg01000188 chr9:133769184 QRFP -0.56 -7.58 -0.39 3.57e-13 Response to amphetamines; CRC cis rs12780046 0.536 rs2862599 chr10:101085582 G/A cg26459859 chr10:101118273 CNNM1 -0.44 -5.96 -0.31 6.66e-9 Non-glioblastoma glioma; CRC trans rs2303319 0.504 rs62189046 chr2:162612371 C/G cg04551154 chr10:95462393 C10orf4 -0.75 -6.37 -0.33 6.43e-10 Cognitive function; CRC cis rs1008375 1.000 rs4698198 chr4:17656536 G/A cg16339924 chr4:17578868 LAP3 0.59 8.0 0.4 2.12e-14 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs17253792 0.915 rs76952651 chr14:56188994 G/A cg01858014 chr14:56050164 KTN1 -0.75 -5.7 -0.3 2.69e-8 Putamen volume; CRC cis rs72717009 0.756 rs10494359 chr1:161463876 G/C cg10431340 chr1:161279108 MPZ -0.57 -7.49 -0.38 6.53e-13 Rheumatoid arthritis; CRC cis rs8078723 0.668 rs3859192 chr17:38128648 C/T cg17344932 chr17:38183730 MED24;SNORD124 -0.52 -8.28 -0.42 3.21e-15 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); CRC cis rs9467711 0.538 rs35942482 chr6:26444938 T/A cg12315302 chr6:26189340 HIST1H4D 0.82 6.33 0.33 8.12e-10 Autism spectrum disorder or schizophrenia; CRC cis rs9818758 0.882 rs74926817 chr3:49378833 C/G cg00383909 chr3:49044727 WDR6 0.72 7.36 0.38 1.52e-12 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; CRC cis rs9916302 0.660 rs665413 chr17:37455678 T/A cg15445000 chr17:37608096 MED1 -0.35 -6.17 -0.32 2.03e-9 Glomerular filtration rate (creatinine); CRC cis rs4713118 0.513 rs200971 chr6:27858904 C/T cg15786705 chr6:28176104 NA 0.54 7.4 0.38 1.16e-12 Parkinson's disease; CRC cis rs1153858 1.000 rs56806728 chr15:45637814 A/G cg14582100 chr15:45693742 SPATA5L1 0.28 5.87 0.31 1.07e-8 Homoarginine levels; CRC cis rs3772130 0.962 rs4280673 chr3:121526107 C/T cg20356878 chr3:121714668 ILDR1 0.51 8.05 0.41 1.5e-14 Cognitive performance; CRC trans rs9354308 0.899 rs2814099 chr6:66555130 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.47 5.97 0.31 6.27e-9 Metabolite levels; CRC cis rs3820068 0.581 rs6666373 chr1:15939884 A/T cg27534772 chr1:16042836 PLEKHM2 0.53 10.39 0.5 4.58e-22 Systolic blood pressure; CRC cis rs853679 0.542 rs2295594 chr6:28053097 G/A cg18032046 chr6:28092343 ZSCAN16 -0.5 -5.94 -0.31 7.43e-9 Depression; CRC cis rs9467711 0.606 rs9366656 chr6:26434630 T/C cg16898833 chr6:26189333 HIST1H4D 0.94 7.65 0.39 2.25e-13 Autism spectrum disorder or schizophrenia; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg25055477 chr6:34360916 NUDT3 0.41 6.13 0.32 2.5e-9 Response to antipsychotic treatment; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg15605011 chr1:110162477 AMPD2 0.43 7.53 0.38 5.02e-13 Liver disease severity in Alagille syndrome; CRC cis rs7680126 0.596 rs4698030 chr4:10315850 A/G cg00071950 chr4:10020882 SLC2A9 -0.45 -5.99 -0.31 5.53e-9 Urate levels in lean individuals;Urate levels in overweight individuals;Urate levels in obese individuals; CRC cis rs1448094 0.512 rs12297441 chr12:86233980 C/T cg25456477 chr12:86230367 RASSF9 0.33 5.72 0.3 2.43e-8 Major depressive disorder; CRC cis rs9311676 0.656 rs6773193 chr3:58385960 C/T cg06643156 chr3:58380774 PXK 0.41 6.33 0.33 7.82e-10 Systemic lupus erythematosus; CRC cis rs3790645 1.000 rs282177 chr1:26899125 C/T cg23229016 chr1:26872525 RPS6KA1 0.24 5.7 0.3 2.65e-8 Glucose homeostasis traits; CRC cis rs4862750 0.914 rs6553028 chr4:187876046 T/C cg10295955 chr4:187884368 NA -1.01 -23.12 -0.79 6.45e-71 Lobe attachment (rater-scored or self-reported); CRC cis rs9527 0.590 rs1926037 chr10:104878010 A/C cg15744005 chr10:104629667 AS3MT -0.31 -6.1 -0.32 3.05e-9 Arsenic metabolism; CRC cis rs597539 0.652 rs488363 chr11:68658298 C/G cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.9 15.68 0.65 8.67e-42 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs9905704 0.801 rs2013182 chr17:56637770 G/A cg12560992 chr17:57184187 TRIM37 -0.59 -8.61 -0.43 2.97e-16 Testicular germ cell tumor; CRC cis rs116095464 0.558 rs10059907 chr5:205360 G/C cg22857025 chr5:266934 NA -1.14 -11.82 -0.55 4.15e-27 Breast cancer; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg14906251 chr6:40555731 LRFN2 0.45 6.25 0.33 1.25e-9 Anxiety disorder; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg10033612 chr16:1664176 CRAMP1L 0.4 7.09 0.36 8.29e-12 Liver disease severity in Alagille syndrome; CRC cis rs3785574 0.962 rs2584630 chr17:61887561 T/A cg11494091 chr17:61959527 GH2 0.37 5.69 0.3 2.88e-8 Height; CRC trans rs7615952 0.512 rs2979334 chr3:125358824 G/A cg07211511 chr3:129823064 LOC729375 -0.63 -8.76 -0.43 1.03e-16 Blood pressure (smoking interaction); CRC cis rs875971 0.862 rs4718383 chr7:66108409 T/C cg11764359 chr7:65958608 NA -0.59 -8.78 -0.44 9.27e-17 Aortic root size; CRC trans rs3806843 0.838 rs2337514 chr5:140132732 T/C cg06840491 chr10:48416966 GDF2 -0.35 -6.04 -0.32 4.16e-9 Depressive symptoms (multi-trait analysis); CRC cis rs1816752 0.905 rs1050112 chr13:25009297 G/T cg02811702 chr13:24901961 NA 0.48 6.66 0.34 1.16e-10 Obesity-related traits; CRC cis rs11764590 0.724 rs1533829 chr7:2082841 A/G cg25834613 chr7:1915315 MAD1L1 -0.34 -5.73 -0.3 2.28e-8 Neuroticism; CRC cis rs6089584 0.854 rs2380146 chr20:60632233 C/T cg18761221 chr20:60518478 NA 0.48 7.87 0.4 5.33e-14 Body mass index; CRC cis rs1552244 0.882 rs3732967 chr3:10015437 T/C cg02579736 chr3:10068473 FANCD2;CIDECP 0.93 11.94 0.55 1.55e-27 Alzheimer's disease; CRC cis rs6693567 0.565 rs1262432 chr1:150371839 C/A cg15654264 chr1:150340011 RPRD2 0.44 6.63 0.34 1.42e-10 Migraine; CRC trans rs1814175 0.935 rs10839329 chr11:49694206 G/A cg11707556 chr5:10655725 ANKRD33B -0.43 -8.03 -0.4 1.81e-14 Height; CRC cis rs7618915 0.547 rs11130314 chr3:52697082 T/C cg05573699 chr3:52720067 GNL3;PBRM1 -0.47 -6.77 -0.35 6.02e-11 Bipolar disorder; CRC cis rs7659604 0.592 rs56077950 chr4:122721412 C/T cg06713675 chr4:122721982 EXOSC9 -0.52 -8.35 -0.42 1.95e-15 Type 2 diabetes; CRC cis rs11971779 0.616 rs1133068 chr7:139053143 G/A cg23387468 chr7:139079360 LUC7L2 0.41 7.04 0.36 1.14e-11 Diisocyanate-induced asthma; CRC cis rs875971 1.000 rs12698523 chr7:65968113 C/G cg18876405 chr7:65276391 NA 0.51 8.78 0.44 9.39e-17 Aortic root size; CRC cis rs1799949 1.000 rs33918839 chr17:41329172 T/C cg19454999 chr17:41278357 BRCA1;NBR2 0.55 8.62 0.43 2.95e-16 Menopause (age at onset); CRC cis rs9462027 0.606 rs4624858 chr6:34802301 C/T cg07306190 chr6:34760872 UHRF1BP1 -0.34 -6.04 -0.32 4.16e-9 Systemic lupus erythematosus; CRC cis rs17376456 1.000 rs34756085 chr5:93556294 A/G cg25358565 chr5:93447407 FAM172A 1.05 9.72 0.47 8.7e-20 Diabetic retinopathy; CRC cis rs7552404 0.727 rs12093623 chr1:76256232 T/G cg22875332 chr1:76189707 ACADM 0.6 7.8 0.4 8e-14 Blood metabolite levels;Acylcarnitine levels; CRC cis rs3806843 1.000 rs10477034 chr5:140169730 A/G cg19875535 chr5:140030758 IK 0.6 9.79 0.47 5.09e-20 Depressive symptoms (multi-trait analysis); CRC cis rs9916302 0.904 rs8079560 chr17:37497661 C/T cg00129232 chr17:37814104 STARD3 0.54 8.16 0.41 7.42e-15 Glomerular filtration rate (creatinine); CRC cis rs9303401 0.614 rs28651036 chr17:57080471 G/A cg10487724 chr17:56770010 TEX14;RAD51C 0.72 9.2 0.45 4.17e-18 Cognitive test performance; CRC cis rs7731657 0.537 rs7725020 chr5:130285115 C/G cg08523029 chr5:130500466 HINT1 0.49 6.19 0.32 1.83e-9 Fasting plasma glucose; CRC cis rs4319547 0.695 rs6488958 chr12:122880704 A/G cg23029597 chr12:123009494 RSRC2 -0.57 -7.4 -0.38 1.15e-12 Body mass index; CRC cis rs7927771 1.000 rs34128973 chr11:47851376 C/T cg20307385 chr11:47447363 PSMC3 -0.49 -6.56 -0.34 2.04e-10 Subjective well-being; CRC cis rs2239547 0.522 rs2581805 chr3:52979050 T/C cg18404041 chr3:52824283 ITIH1 0.34 6.37 0.33 6.29e-10 Schizophrenia; CRC cis rs2739330 0.796 rs1006771 chr22:24314006 G/T cg11905131 chr22:24372483 LOC391322 -0.64 -10.11 -0.49 4.17e-21 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs4731207 0.596 rs12111658 chr7:124584768 A/G cg23710748 chr7:124431027 NA -0.38 -6.08 -0.32 3.35e-9 Cutaneous malignant melanoma; CRC cis rs735539 1.000 rs735539 chr13:21280034 A/G cg04906043 chr13:21280425 IL17D 0.46 7.08 0.36 8.97e-12 Dental caries; CRC cis rs9611565 0.546 rs5758431 chr22:42109917 A/G cg06634786 chr22:41940651 POLR3H 0.6 7.02 0.36 1.24e-11 Vitiligo; CRC cis rs2457480 0.543 rs1482473 chr10:44707598 G/C cg09554077 chr10:44749378 NA 0.48 6.31 0.33 9.16e-10 Coronary artery disease; CRC cis rs12024301 0.557 rs3889889 chr1:183621446 T/C cg11505048 chr1:183622726 RGL1;APOBEC4 0.78 6.44 0.33 4.11e-10 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs8022206 0.841 rs1958113 chr14:68637906 A/T cg19578161 chr14:68482919 RAD51L1 0.42 5.66 0.3 3.38e-8 Platelet count;Mean platelet volume; CRC cis rs10504229 0.636 rs10958525 chr8:58051528 C/A cg24829409 chr8:58192753 C8orf71 -0.44 -5.85 -0.31 1.17e-8 Developmental language disorder (linguistic errors); CRC cis rs875971 0.862 rs2420611 chr7:65999320 A/G cg18876405 chr7:65276391 NA 0.52 8.37 0.42 1.64e-15 Aortic root size; CRC cis rs7843479 0.601 rs3824338 chr8:21864540 A/C cg16476235 chr8:21771668 DOK2 0.39 6.85 0.35 3.62e-11 Mean corpuscular volume; CRC cis rs12477438 0.765 rs6754843 chr2:99680485 C/T cg14399236 chr2:99771627 LIPT1;TSGA10 -0.6 -8.19 -0.41 6.03e-15 Chronic sinus infection; CRC cis rs28386778 0.897 rs7210443 chr17:61785374 A/G cg06873352 chr17:61820015 STRADA 0.78 14.69 0.63 6.4e-38 Prudent dietary pattern; CRC cis rs10197940 0.624 rs10497082 chr2:152355258 T/C cg19508488 chr2:152266495 RIF1 0.6 8.27 0.41 3.47e-15 Lung cancer; CRC cis rs2228479 0.850 rs45567439 chr16:89814604 G/A cg06558623 chr16:89946397 TCF25 1.15 10.8 0.51 1.85e-23 Skin colour saturation; CRC cis rs826838 0.967 rs11183022 chr12:38652519 G/A cg13010199 chr12:38710504 ALG10B 0.45 6.0 0.31 5.12e-9 Heart rate; CRC cis rs17331151 0.505 rs13066644 chr3:52565247 G/A cg07884673 chr3:53033167 SFMBT1 0.76 6.08 0.32 3.31e-9 Immune reponse to smallpox (secreted IL-2); CRC cis rs548181 0.577 rs569766 chr11:125532369 G/A cg03464685 chr11:125439445 EI24 1.07 11.38 0.53 1.58e-25 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs1465370 0.720 rs7811462 chr7:130017487 G/A cg03229158 chr7:130009420 NA 0.44 6.26 0.33 1.23e-9 Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction);Waist circumference adjusted for BMI in active individuals;Waist circumference adjusted for body mass index; CRC cis rs6952808 0.723 rs4721295 chr7:2036669 G/T cg20295408 chr7:1910781 MAD1L1 0.4 5.72 0.3 2.38e-8 Bipolar disorder and schizophrenia; CRC cis rs11583043 0.575 rs12759611 chr1:101587145 T/G cg16556008 chr1:101360663 SLC30A7;EXTL2 0.45 5.79 0.3 1.62e-8 Ulcerative colitis;Inflammatory bowel disease; CRC cis rs9372498 0.536 rs9481825 chr6:118876092 C/T cg07617317 chr6:118971624 C6orf204 0.49 6.22 0.32 1.51e-9 Diastolic blood pressure; CRC cis rs921968 0.643 rs4674324 chr2:219523433 T/G cg02176678 chr2:219576539 TTLL4 0.5 7.96 0.4 2.79e-14 Mean corpuscular hemoglobin concentration; CRC cis rs1552244 1.000 rs61077902 chr3:10126153 T/G cg18598329 chr3:10140678 FANCD2;C3orf24 -0.88 -12.18 -0.56 1.96e-28 Alzheimer's disease; CRC cis rs34779708 0.966 rs12782948 chr10:35450607 G/A cg03585969 chr10:35415529 CREM 0.57 7.63 0.39 2.58e-13 Inflammatory bowel disease;Crohn's disease; CRC cis rs1552244 0.882 rs113268531 chr3:10167069 A/G cg18598329 chr3:10140678 FANCD2;C3orf24 -0.85 -11.33 -0.53 2.36e-25 Alzheimer's disease; CRC cis rs2811415 0.597 rs6802633 chr3:127774722 A/G cg13719885 chr3:127795394 NA -0.36 -5.62 -0.3 4.17e-8 Lung function (FEV1/FVC); CRC cis rs8180040 0.620 rs7373821 chr3:47080127 A/C cg10298567 chr3:47292165 KIF9 -0.38 -5.96 -0.31 6.55e-9 Colorectal cancer; CRC cis rs7224685 0.501 rs781852 chr17:3953102 A/G cg09597638 chr17:3907349 NA 0.65 11.76 0.54 6.61e-27 Type 2 diabetes; CRC cis rs10911251 0.508 rs6424890 chr1:183112764 A/G ch.1.3577855R chr1:183094577 LAMC1 0.83 14.65 0.63 9.3e-38 Colorectal cancer; CRC cis rs514406 0.644 rs7529978 chr1:53204705 G/A cg27535305 chr1:53392650 SCP2 0.34 6.36 0.33 6.57e-10 Monocyte count; CRC cis rs6424115 0.830 rs2501431 chr1:24201643 G/A cg10978503 chr1:24200527 CNR2 0.61 11.06 0.52 2.22e-24 Immature fraction of reticulocytes; CRC trans rs4263408 0.934 rs9683743 chr4:39703194 A/C cg27286572 chr17:3796072 CAMKK1 -0.46 -7.01 -0.36 1.32e-11 Plasma amyloid beta peptide concentrations (ABx-40); CRC cis rs6952809 0.532 rs2057840 chr7:2432797 C/G cg23289794 chr7:2394357 EIF3B -0.65 -8.21 -0.41 5.18e-15 Multiple sclerosis; CRC trans rs1005277 0.603 rs1998062 chr10:38457652 G/C cg27523141 chr10:43048294 ZNF37B 0.5 7.32 0.37 1.98e-12 Extrinsic epigenetic age acceleration; CRC cis rs4927850 0.709 rs6765762 chr3:195652851 G/A cg01181863 chr3:195395398 SDHAP2 -0.77 -9.94 -0.48 1.53e-20 Pancreatic cancer; CRC cis rs875971 0.862 rs6958294 chr7:65794796 C/A cg00343986 chr7:65444356 GUSB -0.45 -6.17 -0.32 1.99e-9 Aortic root size; CRC cis rs6860806 0.631 rs4705931 chr5:131588345 T/C cg22638593 chr5:131593259 PDLIM4 0.42 7.75 0.39 1.13e-13 Breast cancer; CRC cis rs7927771 0.524 rs7111576 chr11:47787445 G/A cg20307385 chr11:47447363 PSMC3 0.45 6.57 0.34 1.92e-10 Subjective well-being; CRC cis rs736408 0.924 rs2535629 chr3:52833219 C/T cg15147215 chr3:52552868 STAB1 -0.54 -8.45 -0.42 9.39e-16 Bipolar disorder; CRC cis rs887829 0.531 rs4338954 chr2:234593931 C/G cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.48 -7.45 -0.38 8.03e-13 Metabolic traits;Bilirubin levels;Cholelithiasis-related traits in sickle cell anemia;Metabolite levels;Total bilirubin levels in HIV-1 infection;Serum metabolite levels;Blood metabolite levels; CRC cis rs2882667 0.858 rs4643949 chr5:138372345 C/T cg09476006 chr5:138032270 NA 0.44 7.44 0.38 8.77e-13 Age-related hearing impairment (SNP x SNP interaction); CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg13614946 chr1:100315421 AGL 0.52 6.77 0.35 5.97e-11 Thyroid stimulating hormone; CRC cis rs3820068 0.603 rs41270279 chr1:15988878 A/G cg27534772 chr1:16042836 PLEKHM2 0.55 10.42 0.5 3.63e-22 Systolic blood pressure; CRC cis rs911555 0.511 rs8007489 chr14:104054572 A/G cg12935359 chr14:103987150 CKB 0.41 6.73 0.35 7.37e-11 Intelligence (multi-trait analysis); CRC cis rs2797160 1.000 rs77678056 chr6:126019738 A/G cg05901451 chr6:126070800 HEY2 0.39 5.99 0.31 5.45e-9 Endometrial cancer; CRC trans rs4263408 0.934 rs9683743 chr4:39703194 A/C cg23459997 chr3:9932426 JAGN1 -0.4 -6.01 -0.31 5.05e-9 Plasma amyloid beta peptide concentrations (ABx-40); CRC cis rs2257205 0.667 rs7220884 chr17:56743948 G/A cg25885038 chr17:56607967 SEPT4 -0.52 -5.69 -0.3 2.87e-8 Pancreatic cancer; CRC trans rs1005277 0.602 rs1831315 chr10:38473353 T/C cg17830980 chr10:43048298 ZNF37B -0.59 -9.71 -0.47 9.06e-20 Extrinsic epigenetic age acceleration; CRC cis rs17376456 0.809 rs13177800 chr5:93307350 T/C cg09848695 chr5:92956644 FAM172A;MIR2277 0.65 5.87 0.31 1.08e-8 Diabetic retinopathy; CRC cis rs17152411 0.895 rs66531168 chr10:126586908 T/A cg07906193 chr10:126599966 NA 0.56 6.33 0.33 7.97e-10 Height; CRC cis rs1801251 0.896 rs4973561 chr2:233687337 C/G cg25237894 chr2:233734115 C2orf82 -0.44 -7.06 -0.36 9.66e-12 Coronary artery disease; CRC cis rs9611565 0.694 rs4822032 chr22:41925535 T/C cg03806693 chr22:41940476 POLR3H -0.73 -10.2 -0.49 2.15e-21 Vitiligo; CRC cis rs17767392 0.958 rs722633 chr14:71898788 T/C cg13720639 chr14:72061746 SIPA1L1 -0.55 -6.95 -0.36 1.96e-11 Mitral valve prolapse; CRC cis rs4713118 0.621 rs9368548 chr6:28034737 A/G cg12963246 chr6:28129442 ZNF389 0.47 5.72 0.3 2.34e-8 Parkinson's disease; CRC cis rs10504229 0.683 rs6998040 chr8:58110155 G/T cg02290350 chr8:58132656 NA 0.58 7.92 0.4 3.72e-14 Developmental language disorder (linguistic errors); CRC cis rs7264396 1.000 rs224429 chr20:34152018 A/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.48 -7.88 -0.4 4.7e-14 Total cholesterol levels; CRC trans rs916888 0.773 rs169201 chr17:44790203 A/G cg07870213 chr5:140052090 DND1 1.01 10.96 0.52 5.03e-24 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs7274811 0.554 rs35556109 chr20:32133489 G/A cg07470512 chr20:32255052 NECAB3;C20orf134 -0.44 -5.66 -0.3 3.31e-8 Height; CRC cis rs9583531 0.600 rs1441042 chr13:111365589 T/G cg24331049 chr13:111365604 ING1 0.61 8.19 0.41 5.86e-15 Coronary artery disease; CRC cis rs10504229 0.728 rs59266065 chr8:58156236 A/G cg02290350 chr8:58132656 NA -0.5 -6.19 -0.32 1.75e-9 Developmental language disorder (linguistic errors); CRC cis rs10979 1.000 rs9376756 chr6:143886125 C/T cg25407410 chr6:143891975 LOC285740 -0.81 -13.31 -0.59 1.24e-32 Hypospadias; CRC cis rs4853036 0.951 rs10165061 chr2:70146363 C/T cg02498382 chr2:70120550 SNRNP27 -0.45 -6.92 -0.36 2.36e-11 Colorectal or endometrial cancer; CRC cis rs7258465 0.931 rs271626 chr19:18627067 C/T cg10790698 chr19:18539756 SSBP4 0.46 8.68 0.43 1.84e-16 Breast cancer; CRC cis rs9814567 1.000 rs4423809 chr3:134300107 A/G cg06109529 chr3:134205091 CEP63;ANAPC13 0.82 11.96 0.55 1.33e-27 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs739401 0.572 rs739399 chr11:3016452 A/G cg05729581 chr11:3078854 CARS -0.55 -8.27 -0.41 3.43e-15 Longevity; CRC cis rs11098499 0.562 rs58583086 chr4:120556362 A/G cg24375607 chr4:120327624 NA -0.41 -6.44 -0.33 4.12e-10 Corneal astigmatism; CRC cis rs3126085 0.935 rs4845426 chr1:152195359 A/G cg09127314 chr1:152161683 NA 0.46 5.93 0.31 7.56e-9 Atopic dermatitis; CRC cis rs116095464 0.614 rs78905930 chr5:246560 G/A cg22496380 chr5:211416 CCDC127 -0.9 -10.19 -0.49 2.2e-21 Breast cancer; CRC cis rs10791323 0.604 rs2250025 chr11:133710914 G/A cg03690763 chr11:133734501 NA -0.35 -5.86 -0.31 1.13e-8 Childhood ear infection; CRC cis rs9649213 0.593 rs3801264 chr7:97950620 A/G cg24562669 chr7:97807699 LMTK2 0.42 7.04 0.36 1.1e-11 Prostate cancer (SNP x SNP interaction); CRC cis rs711245 0.573 rs11899523 chr2:36800918 T/C cg01206211 chr2:36825736 FEZ2 0.46 7.16 0.37 5.27e-12 Height; CRC cis rs7827545 0.545 rs4909477 chr8:135562976 A/G cg17885191 chr8:135476712 NA 0.64 7.62 0.39 2.81e-13 Hypertension (SNP x SNP interaction); CRC cis rs2237234 1.000 rs2237234 chr6:26391394 G/A cg14345882 chr6:26364793 BTN3A2 0.48 6.19 0.32 1.83e-9 Autism spectrum disorder or schizophrenia; CRC cis rs1862618 0.671 rs2591965 chr5:56236176 T/C cg24531977 chr5:56204891 C5orf35 0.67 10.23 0.49 1.61e-21 Initial pursuit acceleration; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg11310125 chr2:113239311 TTL 0.4 6.42 0.33 4.72e-10 Liver disease severity in Alagille syndrome; CRC cis rs7551222 0.749 rs6594018 chr1:204568152 A/G cg07972458 chr1:204535000 NA 0.37 5.72 0.3 2.34e-8 Schizophrenia; CRC trans rs1814175 0.781 rs1851872 chr11:50009770 A/G cg03929089 chr4:120376271 NA -0.95 -19.14 -0.73 2.04e-55 Height; CRC cis rs2153535 0.580 rs1577468 chr6:8444266 C/A cg21535247 chr6:8435926 SLC35B3 0.49 7.35 0.38 1.62e-12 Motion sickness; CRC cis rs12887734 0.546 rs12886637 chr14:104222892 A/G cg01849466 chr14:104193079 ZFYVE21 0.47 7.36 0.38 1.48e-12 Schizophrenia;Autism spectrum disorder or schizophrenia; CRC cis rs79349575 0.783 rs12453374 chr17:46994846 G/C cg00947319 chr17:47005597 UBE2Z -0.34 -5.81 -0.3 1.5e-8 Type 2 diabetes; CRC trans rs2797160 1.000 rs1832980 chr6:125997444 T/G cg05039488 chr6:79577232 IRAK1BP1 -0.51 -7.7 -0.39 1.62e-13 Endometrial cancer; CRC cis rs394563 0.591 rs805026 chr6:149728254 G/C cg16235748 chr6:149772707 ZC3H12D -0.37 -6.73 -0.35 7.69e-11 Dupuytren's disease; CRC trans rs7011507 0.945 rs13268843 chr8:49201957 C/T cg04544946 chr8:978226 NA 0.45 5.99 0.31 5.52e-9 Inflammatory bowel disease;Ulcerative colitis; CRC cis rs7208859 0.673 rs2433 chr17:29226228 T/C cg14008862 chr17:28927542 LRRC37B2 0.55 5.75 0.3 2.04e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs6952808 0.825 rs4236277 chr7:1942270 C/T cg22963979 chr7:1858916 MAD1L1 -0.51 -7.63 -0.39 2.51e-13 Bipolar disorder and schizophrenia; CRC cis rs72615157 0.612 rs7786505 chr7:99817585 G/T cg19337854 chr7:99768885 GPC2 0.44 5.89 0.31 9.65e-9 Lung function (FEV1/FVC); CRC cis rs10832963 1.000 rs10832962 chr11:18656271 C/T cg20219074 chr11:18656078 SPTY2D1 0.6 8.48 0.42 7.85e-16 Breast cancer; CRC cis rs13108904 0.935 rs3755920 chr4:1243617 T/C cg16405210 chr4:1374714 KIAA1530 -0.49 -6.98 -0.36 1.61e-11 Obesity-related traits; CRC cis rs427943 0.750 rs2838807 chr21:46619001 A/G cg19498844 chr21:46707878 POFUT2;LOC642852 0.44 5.93 0.31 7.53e-9 Body mass index; CRC cis rs7586879 0.964 rs4077680 chr2:25122942 A/G cg04586622 chr2:25135609 ADCY3 -0.42 -6.95 -0.36 1.92e-11 Body mass index; CRC cis rs1448094 0.511 rs4492889 chr12:86146735 C/A cg06740227 chr12:86229804 RASSF9 -0.37 -5.64 -0.3 3.71e-8 Major depressive disorder; CRC cis rs826838 0.967 rs1352123 chr12:39130992 T/C cg26384229 chr12:38710491 ALG10B -0.64 -9.67 -0.47 1.21e-19 Heart rate; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg04505727 chr17:79885823 LOC92659;MAFG 0.46 6.43 0.33 4.59e-10 Anxiety disorder; CRC cis rs6089584 0.606 rs2144674 chr20:60576579 G/A cg23463467 chr20:60627584 TAF4 0.4 8.15 0.41 7.93e-15 Body mass index; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg03705947 chr1:68152081 GADD45A 0.54 7.15 0.37 5.76e-12 Thyroid stimulating hormone; CRC cis rs10450586 0.829 rs6484286 chr11:27301922 G/A cg10370305 chr11:27303972 NA 0.37 6.08 0.32 3.41e-9 Total body bone mineral density; CRC cis rs6502050 0.777 rs6502058 chr17:80082500 A/C cg22110888 chr17:80059540 CCDC57 -0.41 -6.39 -0.33 5.58e-10 Life satisfaction; CRC cis rs3771570 1.000 rs62193210 chr2:242323616 G/A cg21155796 chr2:242212141 HDLBP 0.65 7.01 0.36 1.34e-11 Prostate cancer; CRC cis rs11155671 0.530 rs7774787 chr6:150209432 G/A cg07701084 chr6:150067640 NUP43 0.49 7.2 0.37 4.19e-12 Testicular germ cell tumor; CRC cis rs422249 0.512 rs174577 chr11:61604814 A/C cg00603274 chr11:61596626 FADS2 0.4 6.06 0.32 3.69e-9 Trans fatty acid levels; CRC cis rs7586879 0.828 rs4077677 chr2:25122798 G/C cg04586622 chr2:25135609 ADCY3 -0.57 -9.66 -0.47 1.3e-19 Body mass index; CRC cis rs6499255 1.000 rs60231938 chr16:69830415 G/A cg00738113 chr16:70207722 CLEC18C -0.4 -5.74 -0.3 2.15e-8 IgE levels; CRC cis rs7208859 0.673 rs56085216 chr17:29217234 T/C cg13385521 chr17:29058706 SUZ12P 0.65 7.62 0.39 2.68e-13 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs6089584 0.861 rs2180302 chr20:60576369 A/G cg23262073 chr20:60523788 NA -0.41 -6.97 -0.36 1.79e-11 Body mass index; CRC cis rs992157 0.710 rs10167446 chr2:219056866 A/G cg00012203 chr2:219082015 ARPC2 0.59 9.62 0.47 1.85e-19 Colorectal cancer; CRC cis rs6952808 0.608 rs58120505 chr7:2029867 T/C cg22963979 chr7:1858916 MAD1L1 -0.45 -6.78 -0.35 5.63e-11 Bipolar disorder and schizophrenia; CRC trans rs3806843 0.801 rs801171 chr5:140115303 G/A cg06840491 chr10:48416966 GDF2 -0.35 -6.08 -0.32 3.25e-9 Depressive symptoms (multi-trait analysis); CRC cis rs9457247 0.624 rs2239826 chr6:167504880 T/C cg07513332 chr6:167530253 CCR6 0.37 5.9 0.31 9.15e-9 Crohn's disease; CRC cis rs7666738 0.830 rs1426670 chr4:98923572 A/G cg05340658 chr4:99064831 C4orf37 0.6 9.26 0.45 2.73e-18 Colonoscopy-negative controls vs population controls; CRC cis rs3736485 0.966 rs10775144 chr15:51891134 C/T cg08986416 chr15:51914746 DMXL2 -0.45 -6.44 -0.33 4.27e-10 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs9534288 0.797 rs9526127 chr13:46571744 A/G cg15192986 chr13:46630673 CPB2 -0.67 -9.85 -0.48 3.16e-20 Blood protein levels; CRC cis rs4363385 0.747 rs6665575 chr1:152960506 G/A cg25856811 chr1:152973957 SPRR3 -0.27 -7.44 -0.38 8.88e-13 Inflammatory skin disease; CRC cis rs1580019 0.587 rs7805311 chr7:32558302 A/G cg07520158 chr7:32535189 LSM5;AVL9 -0.55 -8.02 -0.4 1.81e-14 Cognitive ability; CRC cis rs1949733 0.701 rs940136 chr4:8448992 G/A cg13073564 chr4:8508604 NA -0.45 -7.04 -0.36 1.15e-11 Response to antineoplastic agents; CRC cis rs4665809 0.567 rs6546848 chr2:26444414 G/C cg22920501 chr2:26401640 FAM59B -0.85 -12.62 -0.57 4.71e-30 Gut microbiome composition (summer); CRC cis rs2979489 0.945 rs12548554 chr8:30346544 G/A cg26383811 chr8:30366931 RBPMS -0.71 -9.83 -0.48 3.53e-20 Mean corpuscular hemoglobin;Plateletcrit;Neutrophil count;Granulocyte count;Sum basophil neutrophil counts;Mean corpuscular volume;Myeloid white cell count;Sum neutrophil eosinophil counts; CRC cis rs9611565 0.512 rs9607842 chr22:42192722 G/A cg06481639 chr22:41940642 POLR3H -0.58 -6.44 -0.33 4.17e-10 Vitiligo; CRC cis rs79349575 0.651 rs4378658 chr17:46993370 G/A cg00947319 chr17:47005597 UBE2Z -0.34 -5.81 -0.3 1.5e-8 Type 2 diabetes; CRC cis rs887829 0.569 rs6711351 chr2:234634916 A/G cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.52 -8.35 -0.42 1.93e-15 Metabolic traits;Bilirubin levels;Cholelithiasis-related traits in sickle cell anemia;Metabolite levels;Total bilirubin levels in HIV-1 infection;Serum metabolite levels;Blood metabolite levels; CRC cis rs11627756 0.915 rs11850368 chr14:103131770 G/C cg12046867 chr14:103022105 NA 0.44 6.05 0.32 3.97e-9 Mean platelet volume; CRC cis rs12024301 0.557 rs12022469 chr1:183601157 C/G cg11505048 chr1:183622726 RGL1;APOBEC4 0.75 6.81 0.35 4.6e-11 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs7618915 0.547 rs13064064 chr3:52657002 T/C cg08222913 chr3:52553049 STAB1 -0.34 -6.12 -0.32 2.65e-9 Bipolar disorder; CRC cis rs7394190 0.748 rs4746151 chr10:75578720 G/T cg07699608 chr10:75541558 CHCHD1 0.59 6.01 0.31 5.03e-9 Incident atrial fibrillation; CRC cis rs9549328 0.670 rs2873372 chr13:113613383 A/G cg20742385 chr13:113633654 MCF2L -0.58 -9.9 -0.48 2.17e-20 Systolic blood pressure; CRC cis rs9372498 0.536 rs13437605 chr6:118899014 C/T cg07617317 chr6:118971624 C6orf204 0.5 6.12 0.32 2.65e-9 Diastolic blood pressure; CRC cis rs9911578 0.967 rs12944948 chr17:56951474 A/G cg05425664 chr17:57184151 TRIM37 -0.49 -7.77 -0.39 9.89e-14 Intelligence (multi-trait analysis); CRC cis rs6088580 0.634 rs6088502 chr20:33037644 A/T cg24642439 chr20:33292090 TP53INP2 0.37 6.23 0.32 1.45e-9 Glomerular filtration rate (creatinine); CRC cis rs4294134 0.935 rs3110823 chr7:135357476 A/C cg20392616 chr7:135392013 SLC13A4 0.49 6.09 0.32 3.09e-9 Paget's disease; CRC cis rs1218582 0.772 rs1109815 chr1:154909268 A/G cg03351412 chr1:154909251 PMVK 0.54 8.59 0.43 3.55e-16 Prostate cancer; CRC cis rs6690583 0.943 rs1837329 chr1:85469614 G/A cg11262906 chr1:85462892 MCOLN2 -0.52 -7.1 -0.36 7.97e-12 Serum sulfate level; CRC cis rs11148252 0.716 rs1887360 chr13:52779166 A/G cg12458913 chr13:53173898 NA 0.48 6.85 0.35 3.58e-11 Lewy body disease; CRC cis rs9486719 0.947 rs12194971 chr6:96911073 T/C cg18709589 chr6:96969512 KIAA0776 -0.51 -5.75 -0.3 2.04e-8 Migraine;Coronary artery disease; CRC trans rs6951245 0.580 rs77101766 chr7:1122438 A/G cg13565492 chr6:43139072 SRF -0.85 -10.64 -0.51 6.4e-23 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs35740288 0.539 rs11629991 chr15:86336664 A/G cg20737812 chr15:86336631 KLHL25 -0.43 -7.07 -0.36 9.54e-12 Eosinophil percentage of white cells;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes; CRC cis rs9527 0.615 rs3897401 chr10:104696379 T/C cg15744005 chr10:104629667 AS3MT -0.31 -6.23 -0.32 1.41e-9 Arsenic metabolism; CRC cis rs7666738 0.830 rs13106434 chr4:98991651 T/A cg17366294 chr4:99064904 C4orf37 0.43 7.27 0.37 2.57e-12 Colonoscopy-negative controls vs population controls; CRC cis rs6901250 1.000 rs6901250 chr6:117114025 A/G cg12892004 chr6:117198278 RFX6 -0.41 -6.42 -0.33 4.64e-10 C-reactive protein levels; CRC cis rs12701220 0.895 rs12534778 chr7:1065861 C/T cg26769984 chr7:1090371 C7orf50 -0.71 -9.32 -0.46 1.75e-18 Bronchopulmonary dysplasia; CRC cis rs7659604 1.000 rs28640980 chr4:122664284 T/C cg19748678 chr4:122722346 EXOSC9 0.55 8.91 0.44 3.63e-17 Type 2 diabetes; CRC cis rs826838 0.838 rs11183646 chr12:38799846 A/T cg13010199 chr12:38710504 ALG10B 0.46 5.98 0.31 5.88e-9 Heart rate; CRC cis rs12826942 1.000 rs12826942 chr12:42796300 A/G cg11827402 chr12:42719852 PPHLN1;ZCRB1 0.6 7.0 0.36 1.48e-11 Coronary artery disease; CRC cis rs7224737 1.000 rs35184688 chr17:40272406 G/C cg20291162 chr17:40259547 DHX58 -0.55 -7.91 -0.4 4e-14 Fibrinogen levels; CRC cis rs6424115 0.767 rs11591202 chr1:24102080 A/C cg15997130 chr1:24165203 NA -0.63 -8.24 -0.41 4.15e-15 Immature fraction of reticulocytes; CRC cis rs62244186 0.659 rs4682745 chr3:44508967 T/C cg11003573 chr3:44754125 ZNF502 -0.33 -5.68 -0.3 2.98e-8 Depressive symptoms; CRC cis rs12142240 0.738 rs17361749 chr1:46806480 C/T cg14993813 chr1:46806288 NSUN4 -0.5 -6.33 -0.33 7.89e-10 Menopause (age at onset); CRC cis rs9814567 1.000 rs7429866 chr3:134236306 C/T cg06541857 chr3:134203789 ANAPC13;CEP63 0.39 5.71 0.3 2.53e-8 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs6502050 0.871 rs62079994 chr17:80076516 T/C cg22110888 chr17:80059540 CCDC57 -0.42 -6.62 -0.34 1.48e-10 Life satisfaction; CRC cis rs7107174 1.000 rs7104222 chr11:78007169 G/A cg02023728 chr11:77925099 USP35 0.5 8.12 0.41 9.14e-15 Testicular germ cell tumor; CRC cis rs7605827 0.930 rs7586201 chr2:15575735 G/A cg19274914 chr2:15703543 NA 0.39 5.86 0.31 1.11e-8 Educational attainment (years of education); CRC cis rs16867321 0.639 rs12466864 chr2:181441417 C/G cg23363182 chr2:181467187 NA 0.6 9.17 0.45 5.12e-18 Obesity; CRC cis rs7647973 1.000 rs62259947 chr3:49439924 T/C cg07636037 chr3:49044803 WDR6 -0.64 -7.44 -0.38 8.68e-13 Menarche (age at onset); CRC cis rs875971 1.000 rs6460296 chr7:65895139 C/T cg18876405 chr7:65276391 NA 0.52 8.85 0.44 5.32e-17 Aortic root size; CRC cis rs9911578 1.000 rs9807057 chr17:56889952 A/C cg12560992 chr17:57184187 TRIM37 0.9 16.65 0.68 1.44e-45 Intelligence (multi-trait analysis); CRC cis rs1552244 0.935 rs28815328 chr3:10062227 G/A cg00166722 chr3:10149974 C3orf24 0.64 8.57 0.43 4.11e-16 Alzheimer's disease; CRC cis rs2180341 1.000 rs2144742 chr6:127595786 C/A cg27446573 chr6:127587934 RNF146 0.99 14.76 0.63 3.48e-38 Breast cancer; CRC trans rs2303319 0.504 rs62188960 chr2:162492578 A/C cg25193742 chr10:104614220 C10orf32 -0.72 -5.97 -0.31 6.32e-9 Cognitive function; CRC cis rs7208859 0.623 rs7219712 chr17:29080570 G/T cg01831904 chr17:28903510 LRRC37B2 -0.63 -6.49 -0.34 3.16e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs17433780 0.808 rs1074541 chr1:89509499 A/G cg09516651 chr1:89888402 LOC400759 0.5 7.85 0.4 5.87e-14 Carotid intima media thickness; CRC cis rs798554 0.757 rs1182181 chr7:2873247 C/G cg04166393 chr7:2884313 GNA12 0.5 6.73 0.35 7.61e-11 Height; CRC cis rs12681287 0.640 rs4490816 chr8:87384938 T/C cg27223183 chr8:87520930 FAM82B 0.52 7.07 0.36 9.37e-12 Caudate activity during reward; CRC trans rs116095464 0.558 rs6882584 chr5:223411 A/C cg00938859 chr5:1591904 SDHAP3 0.68 7.39 0.38 1.24e-12 Breast cancer; CRC cis rs67311347 0.956 rs9822870 chr3:40514890 A/C cg09455208 chr3:40491958 NA -0.45 -9.15 -0.45 6.05e-18 Renal cell carcinoma; CRC cis rs9549328 0.700 rs4907568 chr13:113617574 A/T cg17524180 chr13:113633600 MCF2L -0.53 -9.67 -0.47 1.21e-19 Systolic blood pressure; CRC cis rs13064411 0.696 rs9860549 chr3:113148368 G/A cg18753928 chr3:113234510 CCDC52 -0.51 -7.31 -0.37 1.98e-12 Response to simvastatin treatment (PCSK9 protein level change); CRC cis rs2797160 0.967 rs1739355 chr6:126018114 A/G cg05901451 chr6:126070800 HEY2 0.39 6.03 0.32 4.46e-9 Endometrial cancer; CRC cis rs10504229 0.683 rs58438731 chr8:58134790 C/T cg21724239 chr8:58056113 NA 0.49 6.81 0.35 4.75e-11 Developmental language disorder (linguistic errors); CRC cis rs2430386 1.000 rs2430386 chr2:63178111 C/T cg17519650 chr2:63277830 OTX1 0.51 7.69 0.39 1.69e-13 Prostate cancer; CRC cis rs999943 0.846 rs9348923 chr6:33617924 C/T cg14003231 chr6:33640908 ITPR3 0.93 16.52 0.67 4.52e-45 Obesity (extreme); CRC cis rs7707921 0.957 rs2059891 chr5:81508792 G/C cg17942617 chr5:81327376 ATG10 -0.39 -5.82 -0.31 1.39e-8 Breast cancer; CRC trans rs2228479 0.571 rs62052183 chr16:89966921 C/A cg24644049 chr4:85504048 CDS1 0.77 7.05 0.36 1.06e-11 Skin colour saturation; CRC cis rs4474465 1.000 rs11237509 chr11:78173439 C/A cg27205649 chr11:78285834 NARS2 -0.45 -5.67 -0.3 3.08e-8 Alzheimer's disease (survival time); CRC trans rs747782 0.527 rs12289516 chr11:48234680 G/A cg15704280 chr7:45808275 SEPT13 0.69 6.67 0.35 1.11e-10 Intraocular pressure; CRC cis rs832540 0.695 rs702686 chr5:56201350 A/G cg18230493 chr5:56204884 C5orf35 -0.5 -7.23 -0.37 3.36e-12 Coronary artery disease; CRC cis rs2976388 0.578 rs3736010 chr8:143817503 T/C cg15511327 chr8:143859410 LYNX1 -0.39 -6.13 -0.32 2.52e-9 Urinary tract infection frequency; CRC cis rs67311347 1.000 rs9848083 chr3:40466979 A/G cg24209194 chr3:40518798 ZNF619 -0.43 -6.66 -0.34 1.14e-10 Renal cell carcinoma; CRC cis rs6461049 0.800 rs1860831 chr7:2160931 T/C cg21782813 chr7:2030301 MAD1L1 0.47 8.51 0.42 6.21e-16 Schizophrenia; CRC cis rs7772486 0.686 rs857877 chr6:145976230 A/C cg23711669 chr6:146136114 FBXO30 -0.73 -12.39 -0.56 3.43e-29 Lobe attachment (rater-scored or self-reported); CRC cis rs216205 0.547 rs2641431 chr17:2030507 C/G cg16513277 chr17:2031491 SMG6 -0.5 -6.33 -0.33 8.08e-10 Mitral valve prolapse; CRC cis rs4975709 0.610 rs4975706 chr5:1860365 G/T cg12288994 chr5:1860383 NA 0.39 6.87 0.35 3.16e-11 Cardiovascular disease risk factors; CRC cis rs10504229 0.609 rs66477547 chr8:58105763 A/C cg21724239 chr8:58056113 NA 0.52 6.92 0.36 2.37e-11 Developmental language disorder (linguistic errors); CRC cis rs13392177 0.647 rs6718220 chr2:219066518 T/C cg00012203 chr2:219082015 ARPC2 -0.49 -7.21 -0.37 3.85e-12 Pyoderma gangrenosum in inflammatory bowel disease; CRC cis rs4481887 1.000 rs6666690 chr1:248465323 T/C cg13385794 chr1:248469461 NA 0.37 6.56 0.34 2.1e-10 Common traits (Other); CRC cis rs3736594 0.840 rs57238885 chr2:27974260 C/G cg27432699 chr2:27873401 GPN1 0.59 7.83 0.4 6.61e-14 Fasting blood glucose;Fasting blood glucose (BMI interaction); CRC cis rs6681460 1.000 rs2147777 chr1:67129254 A/T cg02459107 chr1:67143332 SGIP1 0.47 8.26 0.41 3.48e-15 Presence of antiphospholipid antibodies; CRC cis rs1862618 0.802 rs252900 chr5:56185281 T/A cg12311346 chr5:56204834 C5orf35 -0.79 -10.04 -0.48 7.48e-21 Initial pursuit acceleration; CRC cis rs8067545 0.532 rs17759609 chr17:19992514 C/G cg13482628 chr17:19912719 NA 0.4 5.92 0.31 7.89e-9 Schizophrenia; CRC cis rs977987 0.815 rs1364078 chr16:75396881 T/C cg03315344 chr16:75512273 CHST6 0.52 8.81 0.44 7.42e-17 Dupuytren's disease; CRC cis rs10504229 0.679 rs56040464 chr8:58131603 G/A cg02290350 chr8:58132656 NA -0.58 -8.16 -0.41 7.29e-15 Developmental language disorder (linguistic errors); CRC cis rs9329221 0.527 rs4841352 chr8:10327590 A/C cg27411982 chr8:10470053 RP1L1 0.36 5.6 0.3 4.44e-8 Neuroticism; CRC cis rs9487051 0.735 rs455839 chr6:109524221 G/A cg01475377 chr6:109611718 NA -0.34 -5.88 -0.31 1.02e-8 Reticulocyte fraction of red cells; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg12314729 chr11:45361763 NA -0.42 -6.18 -0.32 1.85e-9 Myopia (pathological); CRC cis rs11690935 0.632 rs6433323 chr2:172873060 A/G cg13550731 chr2:172543902 DYNC1I2 -0.68 -10.05 -0.48 6.87e-21 Schizophrenia; CRC cis rs798554 0.759 rs1182189 chr7:2869522 G/A cg13628971 chr7:2884303 GNA12 0.52 6.88 0.35 3.03e-11 Height; CRC cis rs6502050 0.842 rs62079996 chr17:80076862 A/G cg13198984 chr17:80129470 CCDC57 -0.48 -8.57 -0.43 3.99e-16 Life satisfaction; CRC cis rs2242116 0.592 rs2290545 chr3:46967040 C/T cg02527881 chr3:46936655 PTH1R -0.44 -6.7 -0.35 8.92e-11 Birth weight; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg01043910 chr6:132834340 STX7 0.48 7.04 0.36 1.14e-11 Intelligence (multi-trait analysis); CRC cis rs661713 0.734 rs9111 chr6:90981653 C/T cg06866423 chr6:90926672 BACH2 0.38 5.62 0.3 4.18e-8 Hypothyroidism; CRC cis rs4853012 0.838 rs6715351 chr2:74346119 G/A cg20891558 chr2:74357851 NA 0.57 8.97 0.44 2.37e-17 Gestational age at birth (maternal effect); CRC cis rs2070488 1.000 rs13074160 chr3:38455650 G/T cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.9 16.19 0.67 8.85e-44 Electrocardiographic conduction measures; CRC cis rs11229555 0.645 rs12803648 chr11:58177561 G/T cg15696309 chr11:58395628 NA -0.81 -10.45 -0.5 2.9e-22 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg01594514 chr11:67374213 NDUFV1 0.41 6.59 0.34 1.78e-10 Liver disease severity in Alagille syndrome; CRC cis rs10857712 0.904 rs7083614 chr10:135226236 G/A cg01444801 chr10:135216882 MTG1 -0.57 -7.98 -0.4 2.4e-14 Systemic lupus erythematosus; CRC cis rs7666738 0.791 rs10856933 chr4:98958542 C/A cg17366294 chr4:99064904 C4orf37 0.43 7.34 0.38 1.69e-12 Colonoscopy-negative controls vs population controls; CRC cis rs8105895 0.935 rs8103518 chr19:22246952 G/C cg02657401 chr19:22469223 NA -0.34 -5.65 -0.3 3.56e-8 Body mass index (change over time); CRC trans rs10838798 0.504 rs10838852 chr11:48286256 C/T cg15704280 chr7:45808275 SEPT13 -0.49 -6.98 -0.36 1.65e-11 Height; CRC trans rs17685 0.523 rs10246583 chr7:75746667 C/A cg19862616 chr7:65841803 NCRNA00174 0.97 17.96 0.7 9.48e-51 Coffee consumption;Coffee consumption (cups per day); CRC cis rs10504229 0.679 rs12375445 chr8:58040082 A/G cg02725872 chr8:58115012 NA -0.36 -6.04 -0.32 4.18e-9 Developmental language disorder (linguistic errors); CRC cis rs4727027 0.933 rs12154382 chr7:148862284 C/T cg12479418 chr7:148823350 ZNF425;ZNF398 0.42 5.75 0.3 2e-8 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC cis rs7223966 0.921 rs34699959 chr17:61960720 T/G cg23903597 chr17:61704154 MAP3K3 -0.44 -6.05 -0.32 3.99e-9 Hip circumference adjusted for BMI;Body mass index; CRC cis rs875971 1.000 rs2036264 chr7:65799904 G/A cg00343986 chr7:65444356 GUSB -0.43 -6.19 -0.32 1.8e-9 Aortic root size; CRC trans rs9329221 0.651 rs2975648 chr8:10135976 C/T cg16141378 chr3:129829833 LOC729375 0.47 7.21 0.37 3.92e-12 Neuroticism; CRC cis rs1348850 0.914 rs1453370 chr2:178327727 C/T cg02961200 chr2:178257176 LOC100130691;AGPS 0.63 9.29 0.46 2.16e-18 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs10751667 0.621 rs4075990 chr11:976614 T/C cg01483505 chr11:975446 AP2A2 0.46 7.66 0.39 2.11e-13 Alzheimer's disease (late onset); CRC cis rs561341 1.000 rs527256 chr17:30321293 C/G cg19193384 chr17:30244184 NA -0.65 -7.57 -0.39 3.82e-13 Hip circumference adjusted for BMI; CRC cis rs9467773 0.609 rs12663780 chr6:26397573 T/C cg09904177 chr6:26538194 HMGN4 -0.41 -5.64 -0.3 3.73e-8 Intelligence (multi-trait analysis); CRC trans rs800082 0.668 rs9876975 chr3:144292255 G/A cg24215973 chr2:240111563 HDAC4 -0.64 -10.19 -0.49 2.22e-21 Smoking behavior; CRC cis rs1046896 0.553 rs72634343 chr17:80827392 T/C cg19500275 chr17:80737654 TBCD 0.5 6.83 0.35 4.02e-11 Glycated hemoglobin levels; CRC cis rs7762018 0.607 rs80267898 chr6:170040306 G/A cg24289452 chr6:170231220 NA -0.93 -7.55 -0.38 4.3e-13 Thiazide-induced adverse metabolic effects in hypertensive patients; CRC cis rs8077889 0.956 rs116979403 chr17:41849105 G/A cg16892393 chr17:41919603 NA 0.5 6.92 0.36 2.32e-11 Triglycerides; CRC cis rs172166 0.694 rs2791332 chr6:28108788 C/T cg12172441 chr6:28176163 NA 0.53 7.3 0.37 2.19e-12 Cardiac Troponin-T levels; CRC trans rs9784649 0.760 rs17403440 chr5:25054004 C/T cg11038491 chr20:34638489 LOC647979 -0.66 -8.26 -0.41 3.71e-15 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs6700896 0.897 rs2375805 chr1:66156567 C/T cg04111102 chr1:66153794 NA 0.34 5.89 0.31 9.43e-9 C-reactive protein;Mean corpuscular volume;Mean corpuscular hemoglobin; CRC cis rs921968 0.565 rs7599568 chr2:219607819 A/G cg02176678 chr2:219576539 TTLL4 -0.39 -6.31 -0.33 8.76e-10 Mean corpuscular hemoglobin concentration; CRC cis rs4731207 0.698 rs7778544 chr7:124527481 C/T cg23710748 chr7:124431027 NA -0.38 -6.08 -0.32 3.42e-9 Cutaneous malignant melanoma; CRC cis rs12476592 0.602 rs10865338 chr2:63732509 A/G cg10828910 chr2:63850056 LOC388955 0.49 6.08 0.32 3.33e-9 Childhood ear infection; CRC cis rs10751667 0.961 rs7943115 chr11:973885 T/C ch.11.42038R chr11:967971 AP2A2 0.7 11.82 0.55 3.99e-27 Alzheimer's disease (late onset); CRC trans rs10802346 0.545 rs1770003 chr1:246408356 A/G cg22732515 chr19:44031385 ETHE1 0.68 10.19 0.49 2.24e-21 Fractional exhaled nitric oxide (childhood); CRC cis rs6860806 0.632 rs4330455 chr5:131586349 T/C cg22638593 chr5:131593259 PDLIM4 0.39 7.22 0.37 3.56e-12 Breast cancer; CRC cis rs3741151 0.686 rs7927344 chr11:73207517 T/C cg17517138 chr11:73019481 ARHGEF17 0.55 5.86 0.31 1.11e-8 GIP levels in response to oral glucose tolerance test (120 minutes); CRC cis rs4664293 0.867 rs4664301 chr2:160623366 C/T cg08347373 chr2:160653686 CD302 -0.47 -7.43 -0.38 9.32e-13 Monocyte percentage of white cells; CRC cis rs3087591 0.960 rs1013947 chr17:29530362 C/T cg24425628 chr17:29625626 OMG;NF1 0.82 15.89 0.66 1.38e-42 Hip circumference; CRC cis rs4808199 0.895 rs8105984 chr19:19374068 T/C cg03709012 chr19:19516395 GATAD2A 0.97 11.21 0.53 6.56e-25 Nonalcoholic fatty liver disease; CRC cis rs3796352 1.000 rs3796352 chr3:52913279 C/T cg07884673 chr3:53033167 SFMBT1 0.82 6.55 0.34 2.25e-10 Immune reponse to smallpox (secreted IL-2); CRC cis rs7309 0.935 rs11884495 chr2:162059969 A/T cg13854012 chr2:162103682 NA -0.47 -7.55 -0.38 4.37e-13 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Educational attainment; CRC cis rs875971 0.522 rs7784623 chr7:65395034 T/G cg18912574 chr7:65842487 NCRNA00174 0.33 5.62 0.3 4.06e-8 Aortic root size; CRC cis rs55692411 0.517 rs62262106 chr3:49991427 A/G cg24110177 chr3:50126178 RBM5 -0.49 -5.67 -0.3 3.05e-8 Intelligence (multi-trait analysis); CRC cis rs896854 0.967 rs13257021 chr8:95965695 A/G cg23172400 chr8:95962367 TP53INP1 -0.49 -8.25 -0.41 3.74e-15 Type 2 diabetes; CRC cis rs28386778 0.897 rs3785572 chr17:61829989 C/T cg06601766 chr17:61851465 DDX42;CCDC47 0.44 5.97 0.31 6.14e-9 Prudent dietary pattern; CRC cis rs4285028 0.948 rs12493408 chr3:121692119 C/A cg20356878 chr3:121714668 ILDR1 -0.48 -6.91 -0.36 2.51e-11 Multiple sclerosis; CRC cis rs2677744 0.626 rs867468 chr15:91498127 G/A cg23684204 chr15:91497937 RCCD1 0.46 7.03 0.36 1.22e-11 Attention deficit hyperactivity disorder; CRC trans rs7944735 0.671 rs1228044 chr11:48011180 A/G cg03929089 chr4:120376271 NA 0.54 7.23 0.37 3.33e-12 Intraocular pressure; CRC cis rs6933660 0.800 rs6931104 chr6:151786177 C/T cg14262678 chr6:151773367 RMND1;C6orf211 0.54 8.98 0.44 2.1e-17 Menarche (age at onset); CRC cis rs2839186 0.708 rs17183123 chr21:47671961 G/C cg13012494 chr21:47604986 C21orf56 0.44 6.8 0.35 4.81e-11 Testicular germ cell tumor; CRC cis rs6952808 1.000 rs4256490 chr7:1890764 G/A cg02951883 chr7:2050386 MAD1L1 -0.73 -11.48 -0.53 7.11e-26 Bipolar disorder and schizophrenia; CRC cis rs6735179 0.761 rs6723862 chr2:1779260 T/C cg19300414 chr2:1746591 PXDN 0.39 6.5 0.34 2.99e-10 Response to antipsychotic treatment; CRC cis rs10197940 0.578 rs6718372 chr2:152345871 C/G cg19508488 chr2:152266495 RIF1 0.46 6.65 0.34 1.21e-10 Lung cancer; CRC cis rs3733585 0.578 rs6837224 chr4:9955255 G/T cg00071950 chr4:10020882 SLC2A9 -0.55 -9.78 -0.47 5.18e-20 Cleft plate (environmental tobacco smoke interaction); CRC cis rs2204008 0.837 rs12581130 chr12:38319387 A/G cg26384229 chr12:38710491 ALG10B 0.67 9.43 0.46 7.68e-19 Bladder cancer; CRC trans rs10504229 0.906 rs114810777 chr8:58185298 A/G cg04077850 chr5:125800366 GRAMD3 0.37 6.25 0.33 1.3e-9 Developmental language disorder (linguistic errors); CRC cis rs514406 0.621 rs928452 chr1:53195926 G/C cg25767906 chr1:53392781 SCP2 0.42 6.66 0.34 1.15e-10 Monocyte count; CRC cis rs6762 0.692 rs5030778 chr11:836008 T/C cg03885332 chr11:832357 CD151 -0.43 -6.4 -0.33 5.5e-10 Mean platelet volume; CRC cis rs8141529 0.719 rs9625619 chr22:29272328 T/A cg15103426 chr22:29168792 CCDC117 0.51 7.08 0.36 8.51e-12 Lymphocyte counts; CRC cis rs4930561 0.739 rs7118045 chr11:67978734 C/G cg04465784 chr11:67976953 SUV420H1 -0.29 -5.89 -0.31 9.72e-9 Breast cancer in childhood cancer survivors;IgG glycosylation; CRC cis rs4665809 0.590 rs4665837 chr2:26434022 C/A cg25036284 chr2:26402008 FAM59B -0.62 -7.83 -0.4 6.87e-14 Gut microbiome composition (summer); CRC trans rs10875746 0.810 rs10875732 chr12:48442105 A/C cg08231274 chr14:57735852 MUDENG;EXOC5 -0.59 -6.2 -0.32 1.72e-9 Longevity (90 years and older); CRC cis rs6540556 0.723 rs9430014 chr1:209905372 A/C cg05527609 chr1:210001259 C1orf107 -0.56 -6.27 -0.33 1.17e-9 Red blood cell count; CRC cis rs7615952 0.866 rs13063119 chr3:125643847 G/A cg05084668 chr3:125655381 ALG1L -0.64 -9.38 -0.46 1.11e-18 Blood pressure (smoking interaction); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg07035147 chr4:74904607 CXCL3 0.45 6.37 0.33 6.47e-10 Response to antipsychotic treatment; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg20098514 chr17:39845086 EIF1 0.45 6.12 0.32 2.69e-9 Anxiety disorder; CRC cis rs2549003 1.000 rs10068129 chr5:131821246 A/G cg21138405 chr5:131827807 IRF1 -0.57 -11.11 -0.52 1.39e-24 Asthma (sex interaction); CRC cis rs73195822 0.773 rs10849903 chr12:111112319 T/C cg12870014 chr12:110450643 ANKRD13A 0.82 11.61 0.54 2.33e-26 Itch intensity from mosquito bite; CRC cis rs1941023 0.503 rs4939348 chr11:60135871 A/C cg08716584 chr11:60157161 MS4A7 -0.54 -8.98 -0.44 2.16e-17 Congenital heart disease (maternal effect); CRC trans rs12599106 0.792 rs76039834 chr16:34598453 G/A cg18110333 chr6:292329 DUSP22 -0.58 -8.56 -0.43 4.52e-16 Menopause (age at onset); CRC cis rs11997175 0.624 rs12677772 chr8:33772521 T/C cg04338863 chr8:33670619 NA 0.47 7.45 0.38 8.26e-13 Body mass index; CRC cis rs1891275 0.515 rs7093728 chr10:93443617 C/T cg07889827 chr10:93443413 NA -0.39 -6.66 -0.34 1.17e-10 Intelligence (multi-trait analysis); CRC cis rs798766 1.000 rs798744 chr4:1714684 C/A cg05874882 chr4:1763078 NA -0.37 -6.73 -0.35 7.62e-11 Bladder cancer;Urinary bladder cancer; CRC cis rs6502050 0.835 rs34620191 chr17:80149532 G/A cg09264619 chr17:80180166 NA -0.37 -6.17 -0.32 2.04e-9 Life satisfaction; CRC cis rs4363385 0.720 rs1415967 chr1:152965585 C/T cg25856811 chr1:152973957 SPRR3 -0.26 -7.27 -0.37 2.72e-12 Inflammatory skin disease; CRC cis rs4654899 0.680 rs4654881 chr1:21209769 T/C cg02927042 chr1:21476669 EIF4G3 0.36 5.66 0.3 3.33e-8 Superior frontal gyrus grey matter volume; CRC trans rs2727020 0.637 rs1164673 chr11:49328356 C/G cg03929089 chr4:120376271 NA 0.68 10.48 0.5 2.26e-22 Coronary artery disease; CRC cis rs1552244 1.000 rs67006488 chr3:10152993 T/C cg08888203 chr3:10149979 C3orf24 0.7 9.48 0.46 5.31e-19 Alzheimer's disease; CRC trans rs1005277 0.563 rs2800550 chr10:38482929 T/C cg11292332 chr7:45801988 SEPT13 -0.38 -6.83 -0.35 4.14e-11 Extrinsic epigenetic age acceleration; CRC cis rs7647973 1.000 rs62259933 chr3:49469703 G/A cg07636037 chr3:49044803 WDR6 -0.64 -7.59 -0.39 3.33e-13 Menarche (age at onset); CRC cis rs2153535 0.580 rs962590 chr6:8450899 A/G cg07606381 chr6:8435919 SLC35B3 0.68 10.85 0.51 1.2e-23 Motion sickness; CRC cis rs344364 0.552 rs388928 chr16:1909657 G/C cg09830162 chr16:1889614 FAHD1;C16orf73 0.56 8.29 0.42 3.02e-15 Glomerular filtration rate in chronic kidney disease; CRC cis rs4713118 0.629 rs203887 chr6:28021269 C/T cg15786705 chr6:28176104 NA 0.66 8.45 0.42 9.36e-16 Parkinson's disease; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg23330034 chr19:41770021 HNRNPUL1 0.46 6.74 0.35 7.04e-11 Intelligence (multi-trait analysis); CRC cis rs734999 0.545 rs7364820 chr1:2556709 G/A cg18854424 chr1:2615690 NA 0.4 7.53 0.38 4.77e-13 Ulcerative colitis; CRC cis rs7572644 0.640 rs13027427 chr2:28021043 G/T cg27432699 chr2:27873401 GPN1 0.45 5.72 0.3 2.4e-8 Response to carboplatin and paclitaxel in ovarian cancer (Caspase 3/7 EC50); CRC cis rs425277 0.606 rs262669 chr1:2082489 A/G cg04315214 chr1:2043799 PRKCZ 0.4 6.89 0.36 2.77e-11 Height; CRC cis rs7591163 0.959 rs11685995 chr2:228722008 T/C cg20647610 chr2:228736258 WDR69 -0.47 -6.44 -0.33 4.14e-10 Blood pressure; CRC cis rs9527 0.544 rs3781280 chr10:104863843 T/G cg04362960 chr10:104952993 NT5C2 0.59 8.12 0.41 9.58e-15 Arsenic metabolism; CRC cis rs754466 1.000 rs67059283 chr10:79683235 C/T cg17075019 chr10:79541650 NA -0.74 -10.25 -0.49 1.45e-21 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs62064224 0.714 rs4794917 chr17:30636146 C/G cg21839984 chr17:30846986 MYO1D -0.33 -5.74 -0.3 2.15e-8 Schizophrenia; CRC cis rs3008870 0.755 rs2815380 chr1:67510857 A/G cg08660285 chr1:67390436 MIER1;WDR78 -0.62 -9.1 -0.45 9.04e-18 Lymphocyte percentage of white cells; CRC cis rs1707322 0.752 rs4660880 chr1:46111040 C/T cg03146154 chr1:46216737 IPP 0.68 10.01 0.48 9.13e-21 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs7953508 0.711 rs11611927 chr12:93977591 A/G cg18151635 chr12:93972918 NA -0.71 -9.85 -0.48 3.25e-20 Pubertal anthropometrics; CRC cis rs8177253 0.896 rs34252038 chr3:133490621 G/T cg11941060 chr3:133502564 NA -0.58 -10.01 -0.48 9.22e-21 Iron status biomarkers; CRC cis rs6860806 0.632 rs4330455 chr5:131586349 T/C cg18758796 chr5:131593413 PDLIM4 0.43 7.99 0.4 2.33e-14 Breast cancer; CRC cis rs11098499 0.754 rs7672778 chr4:120248585 A/G cg09307838 chr4:120376055 NA 0.62 9.71 0.47 9.4e-20 Corneal astigmatism; CRC cis rs6860806 0.531 rs2631359 chr5:131707892 C/T cg07395648 chr5:131743802 NA 0.43 5.98 0.31 5.88e-9 Breast cancer; CRC cis rs7408868 0.908 rs757474 chr19:15273624 T/C cg14696996 chr19:15285081 NOTCH3 0.97 8.99 0.44 1.99e-17 Pulse pressure; CRC cis rs174601 0.615 rs174534 chr11:61549458 C/T cg00603274 chr11:61596626 FADS2 0.46 7.02 0.36 1.25e-11 Blood metabolite levels;Red blood cell fatty acid levels;Liver enzyme levels (alkaline phosphatase);Gondoic acid (20:1n-9) levels;Trans fatty acid levels; CRC cis rs9287719 0.649 rs9973456 chr2:10718130 C/T cg00105475 chr2:10696890 NA 0.45 7.06 0.36 9.97e-12 Prostate cancer; CRC cis rs6570726 0.935 rs442254 chr6:145849118 T/C cg23711669 chr6:146136114 FBXO30 0.68 12.3 0.56 7.07e-29 Lobe attachment (rater-scored or self-reported); CRC cis rs11190604 1.000 rs11190602 chr10:102297256 T/C cg07080220 chr10:102295463 HIF1AN 0.47 5.68 0.3 2.96e-8 Palmitoleic acid (16:1n-7) levels; CRC cis rs9747201 0.962 rs35051180 chr17:80135046 G/A cg14673194 chr17:80132900 CCDC57 0.49 6.42 0.33 4.73e-10 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs736408 0.812 rs2071508 chr3:52826846 A/G cg11645453 chr3:52864694 ITIH4 -0.41 -6.84 -0.35 3.88e-11 Bipolar disorder; CRC cis rs17155006 0.691 rs409815 chr7:107745443 A/G cg05962710 chr7:107745446 LAMB4 0.4 7.18 0.37 4.65e-12 Pneumococcal bacteremia; CRC cis rs4285028 0.948 rs7651226 chr3:121670802 G/T cg20356878 chr3:121714668 ILDR1 -0.48 -6.95 -0.36 1.93e-11 Multiple sclerosis; CRC cis rs7829975 0.742 rs12547493 chr8:8661534 C/T cg08975724 chr8:8085496 FLJ10661 -0.42 -6.22 -0.32 1.48e-9 Mood instability; CRC cis rs12137294 0.866 rs1172140 chr1:205213024 G/A cg24159697 chr1:205181237 DSTYK -0.34 -6.14 -0.32 2.42e-9 Red cell distribution width; CRC cis rs713477 0.692 rs8019270 chr14:55907172 C/G cg13175173 chr14:55914753 NA -0.43 -7.43 -0.38 9.2e-13 Pediatric bone mineral content (femoral neck); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg26260540 chr19:589513 HCN2 0.33 6.38 0.33 5.96e-10 Liver disease severity in Alagille syndrome; CRC trans rs11146838 1 rs11146838 chr10:39149977 A/T cg18107078 chr1:162760321 HSD17B7 -0.43 -5.96 -0.31 6.38e-9 Breast cancer; CRC cis rs1865760 0.566 rs1971509 chr6:26085777 T/C cg18357526 chr6:26021779 HIST1H4A 0.43 6.09 0.32 3.08e-9 Height; CRC cis rs8060686 0.920 rs73594581 chr16:67955554 G/A cg07125278 chr16:67683757 RLTPR -0.61 -6.74 -0.35 7.23e-11 HDL cholesterol;Metabolic syndrome; CRC cis rs6951245 1.000 rs74785791 chr7:1088494 T/C cg26224354 chr7:1096374 C7orf50;GPR146 -0.94 -11.87 -0.55 2.79e-27 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs7731657 0.537 rs2188957 chr5:130253459 C/T cg08523029 chr5:130500466 HINT1 0.42 5.7 0.3 2.61e-8 Fasting plasma glucose; CRC cis rs875971 0.895 rs4145009 chr7:65726615 T/C cg11764359 chr7:65958608 NA -0.59 -8.95 -0.44 2.64e-17 Aortic root size; CRC cis rs7666738 0.830 rs13118945 chr4:98968586 T/G cg05340658 chr4:99064831 C4orf37 0.6 9.45 0.46 6.71e-19 Colonoscopy-negative controls vs population controls; CRC cis rs9291683 0.546 rs13120348 chr4:10053155 C/G cg11266682 chr4:10021025 SLC2A9 -0.53 -10.84 -0.51 1.33e-23 Bone mineral density; CRC trans rs1997103 1.000 rs10279035 chr7:55412055 C/T cg20935933 chr6:143382018 AIG1 0.51 6.63 0.34 1.35e-10 QRS interval (sulfonylurea treatment interaction); CRC cis rs1577917 0.739 rs9344532 chr6:86234070 A/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A 0.67 8.72 0.43 1.45e-16 Response to antipsychotic treatment; CRC cis rs875971 0.862 rs7782704 chr7:65805366 G/A cg00343986 chr7:65444356 GUSB -0.4 -5.66 -0.3 3.3e-8 Aortic root size; CRC cis rs7618915 0.547 rs4687548 chr3:52666650 A/T cg15147215 chr3:52552868 STAB1 -0.62 -10.31 -0.49 8.6e-22 Bipolar disorder; CRC cis rs4718428 1.000 rs4718428 chr7:66421446 T/G cg25985355 chr7:65971099 NA -0.34 -5.73 -0.3 2.22e-8 Corneal structure; CRC cis rs875971 0.520 rs160645 chr7:65556307 A/G cg18876405 chr7:65276391 NA -0.44 -5.97 -0.31 6.3e-9 Aortic root size; CRC trans rs11098499 0.863 rs2127823 chr4:120485670 G/T cg25214090 chr10:38739885 LOC399744 0.67 10.46 0.5 2.59e-22 Corneal astigmatism; CRC cis rs8044868 0.586 rs12917999 chr16:72089451 T/C cg23815491 chr16:72088622 HP 0.5 7.33 0.37 1.77e-12 Body mass index (change over time) in cancer or chronic obstructive pulmonary disease;Body mass index (change over time) in cancer; CRC cis rs4332037 0.901 rs7791899 chr7:1935988 T/C cg21155852 chr7:2048760 MAD1L1 -0.49 -6.71 -0.35 8.7e-11 Bipolar disorder; CRC cis rs758324 0.755 rs2221674 chr5:131242218 T/A cg25547332 chr5:131281432 NA -0.36 -5.68 -0.3 3.01e-8 Alzheimer's disease in APOE e4- carriers; CRC cis rs9462027 0.606 rs2038841 chr6:34738203 T/C cg07306190 chr6:34760872 UHRF1BP1 -0.35 -6.25 -0.33 1.28e-9 Systemic lupus erythematosus; CRC cis rs9393777 0.623 rs7773938 chr6:26474044 C/T cg12292205 chr6:26970375 C6orf41 -0.53 -5.71 -0.3 2.55e-8 Intelligence (multi-trait analysis); CRC cis rs7659604 0.539 rs7699776 chr4:122753885 A/G cg19748678 chr4:122722346 EXOSC9 0.65 10.42 0.5 3.8e-22 Type 2 diabetes; CRC cis rs6543140 0.964 rs1035126 chr2:103019981 C/T cg04239558 chr2:103089729 SLC9A4 0.36 6.18 0.32 1.95e-9 Blood protein levels; CRC trans rs11039798 0.545 rs7118670 chr11:48532056 C/T cg03929089 chr4:120376271 NA 0.63 6.39 0.33 5.78e-10 Axial length; CRC cis rs10782582 0.609 rs5745430 chr1:76332994 C/T cg03433033 chr1:76189801 ACADM -0.41 -5.87 -0.31 1.06e-8 Daytime sleep phenotypes; CRC cis rs7552404 0.924 rs2173378 chr1:76201992 G/T cg10523679 chr1:76189770 ACADM 0.77 11.7 0.54 1.16e-26 Blood metabolite levels;Acylcarnitine levels; CRC cis rs4268898 0.560 rs78711174 chr2:24496531 G/A cg06627628 chr2:24431161 ITSN2 -0.83 -11.12 -0.52 1.31e-24 Asthma; CRC trans rs6951245 1.000 rs113146460 chr7:1105164 C/G cg13565492 chr6:43139072 SRF -0.72 -7.5 -0.38 6.06e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs7517126 1.000 rs13374399 chr1:196842006 G/A cg13682187 chr1:196946512 CFHR5 -0.37 -6.13 -0.32 2.58e-9 Blood protein levels; CRC cis rs7811142 0.830 rs11769057 chr7:99964661 A/G cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.15 16.85 0.68 2.34e-46 Platelet count; CRC trans rs783540 0.900 rs783525 chr15:83284629 T/A cg18393722 chr15:85113863 UBE2QP1 -0.4 -6.9 -0.36 2.65e-11 Schizophrenia; CRC cis rs7072216 0.763 rs8181292 chr10:100175477 A/G cg26618903 chr10:100175079 PYROXD2 -0.52 -8.44 -0.42 1.02e-15 Metabolite levels; CRC cis rs7811142 1.000 rs67163493 chr7:100023838 C/T cg00814883 chr7:100076585 TSC22D4 -0.75 -9.48 -0.46 5.22e-19 Platelet count; CRC trans rs11640734 0.609 rs11647746 chr16:89806343 C/A cg24644049 chr4:85504048 CDS1 0.66 6.0 0.31 5.3300000000000004e-09 Interleukin-17 levels; CRC cis rs9467711 0.651 rs17586784 chr6:25935227 C/A cg08501292 chr6:25962987 TRIM38 1.06 9.38 0.46 1.08e-18 Autism spectrum disorder or schizophrenia; CRC cis rs7178572 0.568 rs12905951 chr15:77649431 G/A cg22256960 chr15:77711686 NA -0.65 -9.48 -0.46 5.41e-19 Type 2 diabetes; CRC trans rs2228479 0.867 rs62052187 chr16:89973071 G/A cg21302420 chr1:112162376 RAP1A 0.67 6.6 0.34 1.61e-10 Skin colour saturation; CRC cis rs10870270 1.000 rs7199 chr10:133769848 C/G cg08754478 chr10:133766260 PPP2R2D -0.66 -9.29 -0.46 2.22e-18 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; CRC cis rs4919694 1.000 rs12245779 chr10:104645944 C/A cg04362960 chr10:104952993 NT5C2 1.13 10.19 0.49 2.22e-21 Arsenic metabolism; CRC cis rs10450586 0.932 rs899303 chr11:27309681 A/G cg10370305 chr11:27303972 NA 0.35 5.7 0.3 2.68e-8 Total body bone mineral density; CRC cis rs11711311 0.955 rs12636536 chr3:113474226 G/A cg15478005 chr3:113465772 ATP6V1A;NAA50 0.43 5.98 0.31 5.92e-9 IgG glycosylation; CRC cis rs9549367 0.789 rs2287247 chr13:113889212 A/G cg00898013 chr13:113819073 PROZ -0.45 -6.77 -0.35 5.98e-11 Platelet distribution width; CRC cis rs7937682 0.883 rs1784775 chr11:111472460 T/C cg09085632 chr11:111637200 PPP2R1B -0.97 -18.57 -0.72 3.59e-53 Primary sclerosing cholangitis; CRC cis rs7937682 0.889 rs1784786 chr11:111486043 A/G cg09085632 chr11:111637200 PPP2R1B 0.98 19.99 0.74 9.7e-59 Primary sclerosing cholangitis; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg18796520 chr12:4758272 NDUFA9 0.45 6.36 0.33 6.88e-10 Response to antipsychotic treatment; CRC trans rs4927850 0.723 rs7630825 chr3:195753740 T/C cg16724585 chr3:197361211 NA -0.46 -6.91 -0.36 2.58e-11 Pancreatic cancer; CRC cis rs2243480 0.614 rs34032527 chr7:65565141 C/G cg25985355 chr7:65971099 NA -0.47 -5.65 -0.3 3.54e-8 Diabetic kidney disease; CRC cis rs3782089 1.000 rs3782089 chr11:65336819 C/T cg21890820 chr11:65308645 LTBP3 0.74 5.97 0.31 5.98e-9 Height; CRC cis rs3806843 0.966 rs2563255 chr5:140142547 T/C cg16607685 chr5:140181889 PCDHA2;PCDHA1;PCDHA3 0.26 5.99 0.31 5.59e-9 Depressive symptoms (multi-trait analysis); CRC cis rs9914988 0.887 rs34644886 chr17:27168327 T/C cg07195577 chr17:27052828 TLCD1 0.4 5.68 0.3 3e-8 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs17767392 0.846 rs2332576 chr14:71765507 T/A cg13720639 chr14:72061746 SIPA1L1 -0.45 -6.06 -0.32 3.68e-9 Mitral valve prolapse; CRC cis rs9381040 0.655 rs2268192 chr6:41024626 T/C cg25110423 chr6:41068646 NFYA;LOC221442 -0.38 -5.77 -0.3 1.79e-8 Alzheimer's disease (late onset); CRC cis rs7712401 0.755 rs1545696 chr5:122102442 A/G cg18764291 chr5:122110994 SNX2 0.37 5.91 0.31 8.64e-9 Mean platelet volume; CRC cis rs28386778 0.562 rs721575 chr17:61782920 A/G cg22520471 chr17:61851767 DDX42;CCDC47 -0.65 -9.98 -0.48 1.16e-20 Prudent dietary pattern; CRC cis rs8064299 0.655 rs734232 chr17:72765731 C/T cg25054828 chr17:72772726 NAT9;TMEM104 0.61 9.14 0.45 6.66e-18 Monocyte count; CRC cis rs501120 0.584 rs11238937 chr10:44719816 T/A cg09554077 chr10:44749378 NA 0.65 7.29 0.37 2.37e-12 Coronary artery disease;Coronary heart disease; CRC cis rs9322193 0.923 rs7753812 chr6:150011286 C/T cg07701084 chr6:150067640 NUP43 0.47 6.71 0.35 8.37e-11 Lung cancer; CRC cis rs780096 0.506 rs780100 chr2:27652153 G/T cg17158414 chr2:27665306 KRTCAP3 -0.3 -6.5 -0.34 2.98e-10 Total body bone mineral density; CRC cis rs7666738 0.830 rs35560671 chr4:99069095 G/A cg05340658 chr4:99064831 C4orf37 0.6 9.33 0.46 1.57e-18 Colonoscopy-negative controls vs population controls; CRC cis rs10504229 0.645 rs35142596 chr8:58128151 C/T cg02725872 chr8:58115012 NA -0.64 -11.55 -0.54 3.85e-26 Developmental language disorder (linguistic errors); CRC cis rs877282 0.898 rs11253338 chr10:759559 C/T cg17470449 chr10:769945 NA 0.57 7.72 0.39 1.39e-13 Uric acid levels; CRC cis rs929354 0.713 rs6946947 chr7:156948787 T/C cg16102536 chr7:156981717 UBE3C 0.4 6.69 0.35 9.57e-11 Body mass index; CRC trans rs561341 1.000 rs555629 chr17:30294136 T/C cg20587970 chr11:113659929 NA -1.43 -20.42 -0.75 2e-60 Hip circumference adjusted for BMI; CRC trans rs1005277 0.579 rs2472181 chr10:38386764 T/C cg11292332 chr7:45801988 SEPT13 -0.35 -6.26 -0.33 1.18e-9 Extrinsic epigenetic age acceleration; CRC cis rs1670533 0.932 rs9992925 chr4:1050909 A/T cg27284194 chr4:1044797 NA 0.51 6.23 0.33 1.39e-9 Recombination rate (females); CRC cis rs1799949 0.965 rs8067269 chr17:41235799 C/T cg23758822 chr17:41437982 NA 0.92 17.75 0.7 6.17e-50 Menopause (age at onset); CRC trans rs3806843 0.778 rs2531346 chr5:140126139 T/G cg06840491 chr10:48416966 GDF2 -0.35 -5.99 -0.31 5.61e-9 Depressive symptoms (multi-trait analysis); CRC cis rs9399137 0.507 rs13209780 chr6:135344795 G/C cg24558204 chr6:135376177 HBS1L 0.62 9.51 0.46 4.33e-19 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; CRC cis rs8180040 0.553 rs7620997 chr3:47214122 C/T cg27129171 chr3:47204927 SETD2 -0.63 -9.36 -0.46 1.32e-18 Colorectal cancer; CRC cis rs2933343 0.729 rs1683816 chr3:128651195 G/T cg25356066 chr3:128598488 ACAD9 -0.38 -5.64 -0.3 3.72e-8 IgG glycosylation; CRC cis rs7811142 1.000 rs67040465 chr7:100083078 G/A cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.15 16.07 0.66 2.66e-43 Platelet count; CRC cis rs7811142 1.000 rs66632384 chr7:100018904 G/A cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.74 10.28 0.49 1.11e-21 Platelet count; CRC cis rs6952808 0.792 rs35582663 chr7:1948756 G/A cg00106254 chr7:1943704 MAD1L1 -0.51 -7.3 -0.37 2.22e-12 Bipolar disorder and schizophrenia; CRC cis rs780096 0.526 rs809058 chr2:27616790 T/C cg12648201 chr2:27665141 KRTCAP3 -0.29 -5.77 -0.3 1.86e-8 Total body bone mineral density; CRC cis rs11098499 0.820 rs6829903 chr4:120506884 C/T cg24375607 chr4:120327624 NA 0.49 7.37 0.38 1.4e-12 Corneal astigmatism; CRC cis rs79839061 0.610 rs12651368 chr4:856787 G/A cg07828340 chr4:882639 GAK 1.13 10.96 0.52 4.84e-24 Intelligence (multi-trait analysis); CRC cis rs6860806 0.507 rs169256 chr5:131688533 A/G cg24060327 chr5:131705240 SLC22A5 -0.49 -6.36 -0.33 6.7e-10 Breast cancer; CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg19701416 chr10:28592092 NA -0.52 -6.27 -0.33 1.16e-9 Diisocyanate-induced asthma; CRC cis rs9434723 0.920 rs11801562 chr1:9293156 G/A cg04199779 chr1:9294473 H6PD 0.52 6.06 0.32 3.62e-9 Height; CRC trans rs12439619 0.921 rs56042848 chr15:82527585 A/T cg04831495 chr15:85060580 GOLGA6L5 -0.44 -6.09 -0.32 3.16e-9 Intelligence (multi-trait analysis); CRC cis rs1218582 0.710 rs9794000 chr1:154878876 T/A cg06221963 chr1:154839813 KCNN3 -0.76 -15.27 -0.64 3.51e-40 Prostate cancer; CRC trans rs4689592 0.513 rs3857177 chr4:7066332 G/A cg07817883 chr1:32538562 TMEM39B -0.63 -7.9 -0.4 4.1e-14 Monocyte percentage of white cells; CRC trans rs208520 0.690 rs12197578 chr6:66725905 C/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 1.05 14.77 0.63 3.05e-38 Exhaled nitric oxide output; CRC cis rs2795502 0.882 rs2744091 chr10:43339441 A/G cg20628663 chr10:43360327 NA -0.65 -10.21 -0.49 1.98e-21 Blood protein levels; CRC cis rs4638749 0.677 rs7370742 chr2:108815385 T/C cg25838818 chr2:108905173 SULT1C2 -0.34 -5.72 -0.3 2.4e-8 Blood pressure; CRC cis rs10876993 0.855 rs1689601 chr12:58049557 G/A cg15848620 chr12:58087721 OS9 -0.65 -8.91 -0.44 3.64e-17 Celiac disease or Rheumatoid arthritis; CRC cis rs887829 0.570 rs7563561 chr2:234598991 A/C cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.46 -7.28 -0.37 2.55e-12 Metabolic traits;Bilirubin levels;Cholelithiasis-related traits in sickle cell anemia;Metabolite levels;Total bilirubin levels in HIV-1 infection;Serum metabolite levels;Blood metabolite levels; CRC cis rs477692 0.870 rs512655 chr10:131424547 T/A cg05714579 chr10:131428358 MGMT 0.62 8.96 0.44 2.49e-17 Response to temozolomide; CRC cis rs3617 0.591 rs2276823 chr3:52869263 C/A cg07507251 chr3:52567010 NT5DC2 -0.4 -6.13 -0.32 2.5e-9 Red blood cell count;Autism spectrum disorder or schizophrenia; CRC cis rs6598955 0.543 rs6699798 chr1:26556442 G/T cg04990556 chr1:26633338 UBXN11 0.88 10.68 0.51 4.85e-23 Obesity-related traits; CRC cis rs1538970 0.962 rs4660301 chr1:45820149 T/A cg05343316 chr1:45956843 TESK2 0.69 9.26 0.45 2.7e-18 Platelet count; CRC cis rs9443645 0.869 rs6926537 chr6:79554193 T/A cg05283184 chr6:79620031 NA -0.57 -9.14 -0.45 6.47e-18 Intelligence (multi-trait analysis); CRC cis rs7615952 0.599 rs7631268 chr3:125755664 T/A cg02807482 chr3:125708958 NA -0.45 -5.65 -0.3 3.39e-8 Blood pressure (smoking interaction); CRC cis rs10450586 0.965 rs10450589 chr11:27308819 A/C cg10370305 chr11:27303972 NA 0.36 5.8 0.3 1.59e-8 Total body bone mineral density; CRC cis rs514406 0.505 rs12726160 chr1:53175099 A/G cg24675658 chr1:53192096 ZYG11B -0.65 -10.08 -0.49 5.41e-21 Monocyte count; CRC cis rs7618915 0.571 rs1961959 chr3:52585760 G/C cg10802521 chr3:52805072 NEK4 -0.58 -9.03 -0.45 1.53e-17 Bipolar disorder; CRC cis rs9486715 0.867 rs9372106 chr6:96875058 T/C cg06623918 chr6:96969491 KIAA0776 0.98 18.05 0.71 4.09e-51 Headache; CRC trans rs11098499 0.820 rs6829903 chr4:120506884 C/T cg25214090 chr10:38739885 LOC399744 0.66 10.32 0.49 8.14e-22 Corneal astigmatism; CRC cis rs736408 0.522 rs6445535 chr3:52771468 T/C cg08222913 chr3:52553049 STAB1 -0.33 -6.12 -0.32 2.72e-9 Bipolar disorder; CRC cis rs1448094 0.511 rs4897823 chr12:86161484 C/T cg00310523 chr12:86230176 RASSF9 0.37 6.05 0.32 3.84e-9 Major depressive disorder; CRC cis rs11167764 0.895 rs9324865 chr5:141488792 T/C cg08523384 chr5:141488047 NDFIP1 -0.5 -8.49 -0.42 7.34e-16 Crohn's disease; CRC cis rs7412746 0.634 rs4451553 chr1:150937329 C/T cg10589385 chr1:150898437 SETDB1 0.31 6.63 0.34 1.4e-10 Melanoma; CRC cis rs9611565 0.681 rs6002372 chr22:41801299 A/T cg06634786 chr22:41940651 POLR3H 0.67 7.61 0.39 2.99e-13 Vitiligo; CRC cis rs9868809 0.505 rs28793701 chr3:48762683 C/G cg00383909 chr3:49044727 WDR6 0.9 9.03 0.45 1.47e-17 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; CRC cis rs4690686 0.538 rs7436387 chr4:177257723 T/G cg17059388 chr4:177262070 NA 0.38 5.68 0.3 2.93e-8 Essential tremor; CRC cis rs12024301 0.557 rs75291028 chr1:183609985 T/A cg11505048 chr1:183622726 RGL1;APOBEC4 0.81 7.0 0.36 1.42e-11 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs4713118 0.587 rs61471148 chr6:28037032 T/A cg02631126 chr6:28058918 ZSCAN12L1 0.27 5.76 0.3 1.94e-8 Parkinson's disease; CRC cis rs7949030 0.591 rs35880596 chr11:62369884 C/G cg22862634 chr11:62369728 EML3;MTA2 0.57 9.84 0.48 3.47e-20 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; CRC cis rs2032447 0.507 rs478349 chr6:25894057 T/C cg18357526 chr6:26021779 HIST1H4A 0.55 6.93 0.36 2.2e-11 Intelligence (multi-trait analysis); CRC cis rs8060686 0.920 rs3809630 chr16:67879400 G/A cg07125278 chr16:67683757 RLTPR -0.62 -7.17 -0.37 5.04e-12 HDL cholesterol;Metabolic syndrome; CRC cis rs7020830 0.931 rs6476613 chr9:37084340 A/G cg14294708 chr9:37120828 ZCCHC7 1.1 22.73 0.78 1.94e-69 Schizophrenia; CRC cis rs4478858 0.735 rs6425736 chr1:31784376 T/A cg00250761 chr1:31883323 NA -0.42 -8.0 -0.4 2.13e-14 Alcohol dependence; CRC cis rs11711311 0.911 rs3773681 chr3:113523901 C/T cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.52 -7.04 -0.36 1.12e-11 IgG glycosylation; CRC cis rs1957429 0.808 rs6573581 chr14:65331955 G/A cg23373153 chr14:65346875 NA 0.65 6.68 0.35 9.97e-11 Pediatric areal bone mineral density (radius); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg21062897 chr14:50999680 MAP4K5;ATL1 0.39 6.29 0.33 1.01e-9 Liver disease severity in Alagille syndrome; CRC cis rs4363385 0.747 rs2879488 chr1:152975241 G/A cg25856811 chr1:152973957 SPRR3 -0.25 -6.76 -0.35 6.27e-11 Inflammatory skin disease; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg27408887 chr6:16129570 MYLIP -0.39 -6.01 -0.31 4.88e-9 Myopia (pathological); CRC cis rs7772486 0.743 rs9376955 chr6:145949404 T/A cg05347473 chr6:146136440 FBXO30 0.37 5.69 0.3 2.77e-8 Lobe attachment (rater-scored or self-reported); CRC cis rs4073582 0.595 rs801731 chr11:65938446 G/C cg14036092 chr11:66035641 RAB1B 0.53 8.64 0.43 2.47e-16 Gout; CRC trans rs11227306 0.812 rs11227310 chr11:65584733 A/T cg17712092 chr4:129076599 LARP1B 0.52 6.88 0.35 3.09e-11 DNA methylation (variation); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg04208787 chr11:118966294 H2AFX 0.4 6.01 0.31 4.87e-9 Intelligence (multi-trait analysis); CRC cis rs8180040 0.835 rs6780013 chr3:47452118 G/A cg27129171 chr3:47204927 SETD2 -0.59 -8.75 -0.43 1.11e-16 Colorectal cancer; CRC cis rs1538970 0.924 rs4660851 chr1:45843810 A/T cg05343316 chr1:45956843 TESK2 0.7 9.67 0.47 1.23e-19 Platelet count; CRC cis rs939658 0.805 rs11630571 chr15:79432992 C/A cg17916960 chr15:79447300 NA -0.46 -7.44 -0.38 8.99e-13 Refractive error; CRC cis rs853679 0.517 rs9368554 chr6:28082711 T/C cg12273811 chr6:28175739 NA 0.73 9.18 0.45 4.85e-18 Depression; CRC cis rs990171 1.000 rs6543134 chr2:103050458 T/G cg03938978 chr2:103052716 IL18RAP 0.46 5.91 0.31 8.41e-9 Lymphocyte counts; CRC cis rs4400599 0.618 rs1194602 chr1:154231943 T/C cg26808167 chr1:154192205 UBAP2L;C1orf43 -0.36 -5.69 -0.3 2.75e-8 Platelet distribution width; CRC cis rs7618915 0.547 rs34215106 chr3:52659124 T/C cg18404041 chr3:52824283 ITIH1 -0.43 -8.83 -0.44 6.25e-17 Bipolar disorder; CRC cis rs4285028 0.948 rs12497349 chr3:121708517 T/C cg20356878 chr3:121714668 ILDR1 -0.49 -7.29 -0.37 2.39e-12 Multiple sclerosis; CRC cis rs995000 0.931 rs1168132 chr1:63133468 T/A cg19896129 chr1:63156450 NA -0.42 -6.45 -0.34 3.99e-10 Triglyceride levels; CRC cis rs9292777 0.720 rs12515722 chr5:40412018 C/A cg09067459 chr5:40385259 NA -0.53 -8.69 -0.43 1.72e-16 Crohn's disease;Multiple sclerosis; CRC cis rs7107174 1.000 rs2512535 chr11:77971468 C/T cg02023728 chr11:77925099 USP35 0.52 8.83 0.44 6.58e-17 Testicular germ cell tumor; CRC cis rs9549328 0.614 rs34306822 chr13:113616499 G/A cg08614441 chr13:113633676 MCF2L 0.4 6.97 0.36 1.69e-11 Systolic blood pressure; CRC cis rs17270561 0.609 rs4131670 chr6:25738619 T/C cg16482183 chr6:26056742 HIST1H1C 0.83 10.58 0.5 1.07e-22 Iron status biomarkers; CRC cis rs1832871 0.683 rs62437360 chr6:158720162 G/A cg07165851 chr6:158734300 TULP4 0.62 7.76 0.39 1.11e-13 Height; CRC cis rs9372498 0.536 rs17080302 chr6:118854037 A/G cg18833306 chr6:118973337 C6orf204 0.45 6.01 0.31 4.81e-9 Diastolic blood pressure; CRC cis rs6860806 0.661 rs6890009 chr5:131580033 G/T cg18301423 chr5:131593218 PDLIM4 0.37 6.88 0.35 3.04e-11 Breast cancer; CRC cis rs3126085 0.935 rs3126048 chr1:152260165 T/C cg09127314 chr1:152161683 NA -0.45 -5.86 -0.31 1.14e-8 Atopic dermatitis; CRC cis rs7615952 0.641 rs7618515 chr3:125790578 C/T cg15145296 chr3:125709740 NA -0.58 -6.91 -0.36 2.52e-11 Blood pressure (smoking interaction); CRC cis rs7772486 0.686 rs9390349 chr6:146054430 T/G cg23711669 chr6:146136114 FBXO30 -0.64 -10.66 -0.51 5.7e-23 Lobe attachment (rater-scored or self-reported); CRC cis rs2153535 0.542 rs9378553 chr6:8472632 T/C cg21535247 chr6:8435926 SLC35B3 0.5 7.53 0.38 4.89e-13 Motion sickness; CRC cis rs681343 1.000 rs681343 chr19:49206462 C/T cg21064579 chr19:49206444 FUT2 0.53 9.36 0.46 1.25e-18 Lung adenocarcinoma;Primary sclerosing cholangitis;Childhood ear infection; CRC cis rs4819052 0.851 rs2330011 chr21:46658498 G/A cg02159808 chr21:46707872 POFUT2;LOC642852 0.46 6.07 0.32 3.5e-9 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs11098499 0.657 rs71614442 chr4:120379346 C/T cg24375607 chr4:120327624 NA 0.5 7.71 0.39 1.46e-13 Corneal astigmatism; CRC cis rs270601 0.690 rs162904 chr5:131595784 C/T cg01305625 chr5:131593812 PDLIM4 -0.36 -5.97 -0.31 6.15e-9 Acylcarnitine levels; CRC cis rs4713118 0.662 rs149969 chr6:27977737 A/G cg15786705 chr6:28176104 NA 0.69 9.98 0.48 1.13e-20 Parkinson's disease; CRC cis rs9291683 0.588 rs3756236 chr4:10013463 T/A cg00071950 chr4:10020882 SLC2A9 0.68 13.33 0.59 1.07e-32 Bone mineral density; CRC cis rs972578 1.000 rs1569509 chr22:43359261 A/G cg01576275 chr22:43409880 NA -0.44 -7.21 -0.37 3.75e-12 Mean platelet volume; CRC cis rs10504229 0.679 rs6474100 chr8:58031161 G/A cg22535103 chr8:58192502 C8orf71 -0.44 -5.85 -0.31 1.21e-8 Developmental language disorder (linguistic errors); CRC cis rs7259376 0.869 rs10402396 chr19:22601809 G/C cg02657401 chr19:22469223 NA 0.31 6.82 0.35 4.25e-11 Menopause (age at onset); CRC cis rs651907 0.557 rs13066768 chr3:101486920 A/T cg03837452 chr3:101395095 ZBTB11;LOC100009676 -0.59 -7.95 -0.4 2.94e-14 Colorectal cancer; CRC cis rs7914558 0.966 rs3977751 chr10:104920232 A/G cg15744005 chr10:104629667 AS3MT -0.32 -6.66 -0.34 1.15e-10 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs1005277 0.579 rs1985707 chr10:38434098 C/T cg25517755 chr10:38738941 LOC399744 -0.42 -6.09 -0.32 3.14e-9 Extrinsic epigenetic age acceleration; CRC trans rs1455244 0.700 rs7229302 chr18:11508904 G/T cg05952643 chr9:132597404 C9orf78;USP20 0.45 6.63 0.34 1.38e-10 Schizophrenia; CRC cis rs2836974 0.627 rs7278985 chr21:40653767 C/T cg11890956 chr21:40555474 PSMG1 -0.91 -15.92 -0.66 1.01e-42 Cognitive function; CRC cis rs67311347 0.544 rs9821440 chr3:40342347 T/C cg09455208 chr3:40491958 NA 0.32 6.41 0.33 4.94e-10 Renal cell carcinoma; CRC trans rs9467711 0.606 rs9379899 chr6:26603015 T/A cg06606381 chr12:133084897 FBRSL1 -0.85 -6.44 -0.33 4.18e-10 Autism spectrum disorder or schizophrenia; CRC cis rs7927592 0.763 rs2513277 chr11:68360887 T/G cg01657329 chr11:68192670 LRP5 -0.56 -9.39 -0.46 1.05e-18 Total body bone mineral density; CRC cis rs78456975 1.000 rs72776298 chr2:1570163 C/G cg26248373 chr2:1572462 NA -0.71 -7.95 -0.4 2.92e-14 Placebo response in major depressive disorder (% change in symptom score); CRC cis rs9891119 0.576 rs6503697 chr17:40501579 A/T cg06270615 chr17:40516068 STAT3 -0.35 -7.56 -0.38 3.99e-13 Multiple sclerosis;Crohn's disease; CRC cis rs10911251 0.546 rs2274984 chr1:183107446 A/C ch.1.3577855R chr1:183094577 LAMC1 -0.79 -13.34 -0.59 9.52e-33 Colorectal cancer; CRC cis rs4363385 0.747 rs10494285 chr1:152982285 G/A cg25856811 chr1:152973957 SPRR3 -0.25 -6.85 -0.35 3.56e-11 Inflammatory skin disease; CRC cis rs713477 0.505 rs8019209 chr14:55891329 C/T cg13175173 chr14:55914753 NA -0.48 -7.8 -0.4 8.2e-14 Pediatric bone mineral content (femoral neck); CRC cis rs7552404 1.000 rs6593585 chr1:76140273 G/A cg22875332 chr1:76189707 ACADM 0.67 9.14 0.45 6.46e-18 Blood metabolite levels;Acylcarnitine levels; CRC cis rs13118159 0.836 rs2293630 chr4:1342521 G/A cg19318889 chr4:1322082 MAEA 0.5 7.42 0.38 1.01e-12 Longevity; CRC cis rs1524976 1.000 rs62255278 chr3:65475846 A/T cg16238336 chr3:65465873 MAGI1 -0.54 -7.72 -0.39 1.43e-13 PR interval; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg15806109 chr3:125802485 SLC41A3 0.46 6.4 0.33 5.33e-10 Response to antipsychotic treatment; CRC cis rs10883723 0.810 rs2281879 chr10:104268877 C/G cg11453585 chr10:104263688 ACTR1A;SUFU 0.9 16.76 0.68 5.05e-46 Allergic disease (asthma, hay fever or eczema); CRC cis rs12900413 0.687 rs6496601 chr15:90317694 C/T cg24249390 chr15:90295951 MESP1 -0.59 -9.5 -0.46 4.43e-19 Coronary artery aneurysm in Kawasaki disease; CRC cis rs7493 0.760 rs17876092 chr7:95053313 C/A cg17330251 chr7:94953956 PON1 -0.61 -7.65 -0.39 2.21e-13 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs1267303 0.675 rs1267308 chr1:46987718 A/G cg08533674 chr1:46993347 NA 0.74 9.24 0.45 3.25e-18 Monobrow; CRC cis rs6957923 0.934 rs9969137 chr7:23478288 C/T cg20265043 chr7:23510089 IGF2BP3 0.37 5.61 0.3 4.3e-8 Height; CRC cis rs751728 0.717 rs2281816 chr6:33772335 A/G cg25922239 chr6:33757077 LEMD2 0.47 6.35 0.33 7.09e-10 Crohn's disease; CRC cis rs245880 0.666 rs245894 chr7:29192686 G/C cg17163760 chr7:29186267 CPVL -0.4 -6.9 -0.36 2.6e-11 Warfarin maintenance dose; CRC trans rs1455244 0.700 rs7229302 chr18:11508904 G/T cg12901283 chr17:53045974 COX11;STXBP4 0.45 6.73 0.35 7.69e-11 Schizophrenia; CRC trans rs3780486 0.846 rs3824458 chr9:33144809 C/T cg04842962 chr6:43655489 MRPS18A 1.16 23.7 0.79 3.99e-73 IgG glycosylation; CRC trans rs1005277 0.579 rs2749612 chr10:38488610 G/A cg23533926 chr12:111358616 MYL2 -0.53 -8.04 -0.41 1.59e-14 Extrinsic epigenetic age acceleration; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg05043048 chr1:45266447 PLK3 0.43 6.15 0.32 2.19e-9 Response to antipsychotic treatment; CRC cis rs8177253 0.828 rs8177259 chr3:133480388 T/C cg01448562 chr3:133502909 NA -0.53 -9.09 -0.45 9.72e-18 Iron status biomarkers; CRC cis rs6546550 0.867 rs1551374 chr2:70079633 C/T cg02498382 chr2:70120550 SNRNP27 -0.49 -7.95 -0.4 3.07e-14 Prevalent atrial fibrillation; CRC cis rs7772486 0.875 rs2748482 chr6:146336532 T/C cg23711669 chr6:146136114 FBXO30 0.67 11.53 0.54 4.5e-26 Lobe attachment (rater-scored or self-reported); CRC cis rs9902453 0.838 rs9646436 chr17:28209059 C/T cg26525008 chr17:28256777 EFCAB5;SSH2 0.59 8.81 0.44 7.18e-17 Coffee consumption (cups per day); CRC cis rs1707322 0.721 rs11211178 chr1:46227566 G/T cg06784218 chr1:46089804 CCDC17 0.66 12.26 0.56 9.89e-29 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs9649213 0.593 rs7778015 chr7:97920270 T/C cg24562669 chr7:97807699 LMTK2 0.45 7.54 0.38 4.56e-13 Prostate cancer (SNP x SNP interaction); CRC cis rs6089584 0.816 rs744778 chr20:60631365 A/G cg23463467 chr20:60627584 TAF4 0.35 6.13 0.32 2.51e-9 Body mass index; CRC cis rs561341 1.000 rs72821971 chr17:30269343 T/G cg19193384 chr17:30244184 NA -0.65 -7.51 -0.38 5.54e-13 Hip circumference adjusted for BMI; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg09455096 chr2:61765470 XPO1 0.46 6.46 0.34 3.72e-10 Response to antipsychotic treatment; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg10211518 chr19:633735 POLRMT 0.44 6.07 0.32 3.47e-9 Response to antipsychotic treatment; CRC cis rs883565 0.740 rs10510698 chr3:39107993 A/C cg01426195 chr3:39028469 NA -0.55 -9.07 -0.45 1.11e-17 Handedness; CRC cis rs6951245 0.554 rs58210047 chr7:1149381 G/A cg07217954 chr7:1067459 C7orf50 0.51 5.94 0.31 7.41e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs13108904 0.840 rs13149790 chr4:1262239 A/G cg16405210 chr4:1374714 KIAA1530 -0.43 -5.88 -0.31 1.01e-8 Obesity-related traits; CRC cis rs875971 0.564 rs313804 chr7:65514622 A/G cg18912574 chr7:65842487 NCRNA00174 0.37 6.32 0.33 8.6e-10 Aortic root size; CRC cis rs7618915 0.547 rs34610142 chr3:52708429 G/A cg18404041 chr3:52824283 ITIH1 -0.44 -9.03 -0.45 1.49e-17 Bipolar disorder; CRC cis rs7264396 0.887 rs4911502 chr20:34063034 C/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.38 -6.22 -0.32 1.51e-9 Total cholesterol levels; CRC cis rs7666738 0.791 rs34790496 chr4:98930516 C/T cg17366294 chr4:99064904 C4orf37 0.43 7.19 0.37 4.48e-12 Colonoscopy-negative controls vs population controls; CRC cis rs9527 0.567 rs11191573 chr10:104896816 T/C cg04362960 chr10:104952993 NT5C2 0.6 8.32 0.42 2.32e-15 Arsenic metabolism; CRC cis rs4332037 0.575 rs55952733 chr7:2070680 G/A cg02421172 chr7:1938701 MAD1L1 0.42 5.62 0.3 4.11e-8 Bipolar disorder; CRC cis rs898097 0.625 rs6502017 chr17:80891135 C/T cg03160526 chr17:80928410 B3GNTL1 0.49 8.01 0.4 1.99e-14 Breast cancer; CRC cis rs600626 0.636 rs11236515 chr11:75451411 A/G cg24262691 chr11:75473276 NA 0.52 7.09 0.36 8.39e-12 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CRC cis rs9457247 0.765 rs10946203 chr6:167446735 A/C cg07741184 chr6:167504864 NA 0.39 6.73 0.35 7.52e-11 Crohn's disease; CRC cis rs6951245 1.000 rs80031817 chr7:1096793 T/C cg20603222 chr7:1096387 C7orf50;GPR146 -0.72 -8.67 -0.43 1.96e-16 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs9640161 0.659 rs59572505 chr7:150014986 C/T cg13722127 chr7:150037890 RARRES2 0.47 7.38 0.38 1.26e-12 Blood protein levels;Circulating chemerin levels; CRC cis rs11971779 0.680 rs12154842 chr7:139078484 A/G cg07862535 chr7:139043722 LUC7L2 0.59 7.58 0.39 3.58e-13 Diisocyanate-induced asthma; CRC cis rs68170813 0.559 rs3801959 chr7:106955666 A/G cg02696742 chr7:106810147 HBP1 -0.59 -6.53 -0.34 2.57e-10 Coronary artery disease; CRC cis rs7959452 0.562 rs10878975 chr12:69782044 G/C cg20891283 chr12:69753455 YEATS4 0.91 17.31 0.69 3.38e-48 Blood protein levels; CRC cis rs2032447 0.839 rs199750 chr6:26016462 A/G cg17691542 chr6:26056736 HIST1H1C -0.41 -5.68 -0.3 2.93e-8 Intelligence (multi-trait analysis); CRC cis rs9896933 0.667 rs2253131 chr17:80696547 T/A cg02398342 chr17:80708632 TBCD;FN3K 0.54 6.47 0.34 3.6e-10 Bone mineral accretion in asthma (oral corticosteroid dose interaction); CRC trans rs4073221 0.520 rs13065273 chr3:18194852 T/C cg19396872 chr19:8495671 MARCH2 0.63 6.23 0.32 1.46e-9 Parkinson's disease; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg00873521 chr9:95056130 IARS;SNORA84 0.49 6.91 0.36 2.51e-11 Response to antipsychotic treatment; CRC cis rs9847710 0.524 rs11712910 chr3:53094194 C/A cg18099408 chr3:52552593 STAB1 0.4 5.61 0.3 4.27e-8 Ulcerative colitis; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg17424859 chr6:71319002 NA -0.4 -6.33 -0.33 8.16e-10 Liver disease severity in Alagille syndrome; CRC cis rs79387448 0.701 rs10515921 chr2:102981018 T/G cg09003973 chr2:102972529 NA 0.95 10.12 0.49 3.91e-21 Gut microbiota (bacterial taxa); CRC cis rs9908102 0.710 rs56988654 chr17:12912635 T/G cg26162695 chr17:12921313 ELAC2 0.43 5.85 0.31 1.17e-8 Schizophrenia; CRC trans rs703108 0.731 rs7898954 chr10:22323646 A/G cg03463641 chr2:25565497 DNMT3A -0.49 -5.98 -0.31 5.87e-9 Monocyte percentage of white cells; CRC cis rs8177253 0.930 rs12595 chr3:133496553 T/C cg16262614 chr3:133464971 TF 0.32 5.66 0.3 3.27e-8 Iron status biomarkers; CRC cis rs10760158 0.832 rs10818522 chr9:124019010 A/C cg14417974 chr9:124058376 GSN -0.34 -5.7 -0.3 2.62e-8 Pulse pressure; CRC cis rs889312 0.500 rs252903 chr5:56117952 A/G cg18230493 chr5:56204884 C5orf35 -0.39 -5.98 -0.31 5.98e-9 Breast cancer;Breast cancer (early onset); CRC cis rs9486719 1.000 rs35487471 chr6:96879715 C/T cg06623918 chr6:96969491 KIAA0776 -0.81 -9.51 -0.46 4.17e-19 Migraine;Coronary artery disease; CRC trans rs1814175 0.645 rs28436748 chr11:50046422 G/A cg15704280 chr7:45808275 SEPT13 -0.94 -17.39 -0.69 1.77e-48 Height; CRC cis rs10540 1.000 rs12801148 chr11:511707 T/G cg03576123 chr11:487126 PTDSS2 -1.04 -10.78 -0.51 2.09e-23 Body mass index; CRC cis rs13108904 0.901 rs6826029 chr4:1307689 A/G cg23123621 chr4:1343375 KIAA1530 0.34 6.19 0.32 1.81e-9 Obesity-related traits; CRC cis rs375066 0.623 rs1549957 chr19:44354238 T/C cg19542119 chr19:44331823 ZNF283 0.4 5.61 0.3 4.24e-8 Breast cancer; CRC cis rs7312933 0.703 rs11181378 chr12:42600658 T/C cg19980929 chr12:42632907 YAF2 0.44 6.56 0.34 2.14e-10 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CRC cis rs10504073 0.584 rs7823690 chr8:49943831 G/A cg00325661 chr8:49890786 NA 0.57 10.25 0.49 1.36e-21 Blood metabolite ratios; CRC cis rs1008375 0.966 rs2315553 chr4:17627332 T/C cg02297831 chr4:17616191 MED28 0.47 6.26 0.33 1.22e-9 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs7937682 0.883 rs568506 chr11:111466429 C/T cg19812747 chr11:111475976 SIK2 -0.57 -9.72 -0.47 8.51e-20 Primary sclerosing cholangitis; CRC cis rs1799949 0.965 rs11651623 chr17:41329847 G/A cg19454999 chr17:41278357 BRCA1;NBR2 0.54 8.25 0.41 3.98e-15 Menopause (age at onset); CRC cis rs597539 0.652 rs11603827 chr11:68719221 C/T cg04772025 chr11:68637568 NA 0.46 7.02 0.36 1.27e-11 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs1799949 0.896 rs35908185 chr17:41255111 A/T cg25072359 chr17:41440525 NA 0.47 7.1 0.36 7.51e-12 Menopause (age at onset); CRC cis rs763121 0.853 rs9622833 chr22:39000397 G/A cg06022373 chr22:39101656 GTPBP1 0.76 11.41 0.53 1.3e-25 Menopause (age at onset); CRC cis rs853679 0.517 rs3173443 chr6:28137027 T/G cg23161317 chr6:28129485 ZNF389 0.53 6.43 0.33 4.52e-10 Depression; CRC cis rs637571 0.726 rs689274 chr11:65665988 A/G cg26695010 chr11:65641043 EFEMP2 0.45 6.88 0.35 3.07e-11 Eosinophil percentage of white cells; CRC trans rs17111230 0.675 rs1349568 chr14:41315945 A/C cg19983597 chr14:21852154 SUPT16H 0.43 5.98 0.31 5.97e-9 Congenital heart disease (inherited effect); CRC cis rs73206853 0.841 rs73191829 chr12:110948906 A/G cg12870014 chr12:110450643 ANKRD13A 0.74 6.38 0.33 6.1e-10 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC cis rs1865760 0.566 rs1971509 chr6:26085777 T/C cg17691542 chr6:26056736 HIST1H1C 0.56 8.51 0.42 6.1e-16 Height; CRC cis rs6860806 0.632 rs4330455 chr5:131586349 T/C cg12564285 chr5:131593104 PDLIM4 0.47 9.05 0.45 1.27e-17 Breast cancer; CRC cis rs4654899 1.000 rs7554770 chr1:21481361 A/T cg02927042 chr1:21476669 EIF4G3 -0.48 -7.58 -0.39 3.62e-13 Superior frontal gyrus grey matter volume; CRC cis rs524023 1.000 rs10897518 chr11:64360705 A/G cg06522879 chr11:64358276 SLC22A12 0.59 9.27 0.46 2.44e-18 Urate levels in obese individuals; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg08329777 chr17:79885590 LOC92659;MAFG 0.41 5.97 0.31 6.2e-9 Intelligence (multi-trait analysis); CRC cis rs7677751 0.806 rs7682912 chr4:55085620 T/G cg13615338 chr4:55094005 PDGFRA 0.4 5.81 0.3 1.51e-8 Corneal astigmatism; CRC cis rs2976388 0.647 rs2082801 chr8:143786461 A/G cg20041105 chr8:143859282 LYNX1 0.44 7.85 0.4 5.91e-14 Urinary tract infection frequency; CRC cis rs7737355 0.947 rs1422871 chr5:130942481 G/A cg25547332 chr5:131281432 NA 0.4 5.63 0.3 3.89e-8 Life satisfaction; CRC cis rs453301 0.571 rs2929456 chr8:9083416 G/A cg08975724 chr8:8085496 FLJ10661 -0.41 -6.37 -0.33 6.34e-10 Joint mobility (Beighton score); CRC cis rs1656402 0.954 rs3111399 chr2:233429810 G/A cg03852847 chr2:233439513 NA 0.44 7.51 0.38 5.71e-13 Non-small cell lung cancer (survival); CRC cis rs514406 0.861 rs1749907 chr1:53259658 C/T cg08859206 chr1:53392774 SCP2 0.45 6.96 0.36 1.89e-11 Monocyte count; CRC cis rs10256972 0.516 rs12702081 chr7:1141528 T/C cg27094323 chr7:1216898 NA -0.37 -6.02 -0.31 4.68e-9 Longevity;Endometriosis; CRC cis rs282587 0.569 rs282593 chr13:113378882 T/C cg04656015 chr13:113407548 ATP11A 0.62 7.84 0.4 6.28e-14 Glycated hemoglobin levels; CRC cis rs1218582 0.774 rs2335409 chr1:154916106 G/A cg03351412 chr1:154909251 PMVK 0.5 7.6 0.39 3.06e-13 Prostate cancer; CRC cis rs713587 0.520 rs522806 chr2:25316584 C/A cg22495460 chr2:25135724 ADCY3 0.43 6.47 0.34 3.64e-10 Body mass index in non-asthmatics; CRC cis rs1129187 0.755 rs4714638 chr6:42917017 A/G cg02353165 chr6:42928485 GNMT 0.71 11.63 0.54 1.97e-26 Alzheimer's disease in APOE e4+ carriers; CRC cis rs7811142 0.720 rs112622797 chr7:99917416 G/A cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.1 14.17 0.62 6.75e-36 Platelet count; CRC cis rs875971 1.000 rs1167411 chr7:65539264 C/G cg18876405 chr7:65276391 NA -0.52 -8.83 -0.44 6.37e-17 Aortic root size; CRC cis rs58688157 0.660 rs7117022 chr11:583787 T/C cg01842473 chr11:617407 IRF7;MUPCDH -0.57 -6.93 -0.36 2.16e-11 Systemic lupus erythematosus; CRC trans rs61931739 0.500 rs11053242 chr12:34511625 A/G cg26384229 chr12:38710491 ALG10B 0.62 9.17 0.45 5.2e-18 Morning vs. evening chronotype; CRC cis rs1976403 0.633 rs1697422 chr1:21821897 T/C cg20417195 chr1:21767127 NBPF3 0.41 5.9 0.31 8.86e-9 Liver enzyme levels (alkaline phosphatase); CRC cis rs9393692 0.627 rs2179517 chr6:26198845 G/C cg00631329 chr6:26305371 NA -0.57 -10.41 -0.5 4.07e-22 Educational attainment; CRC cis rs8067545 0.641 rs169412 chr17:19851875 G/T cg04132472 chr17:19861366 AKAP10 0.44 6.94 0.36 2.08e-11 Schizophrenia; CRC trans rs853679 0.546 rs200950 chr6:27835772 A/G cg16898833 chr6:26189333 HIST1H4D 0.72 6.45 0.34 4.08e-10 Depression; CRC trans rs1005277 0.522 rs11011343 chr10:38002698 A/G cg23533926 chr12:111358616 MYL2 -0.45 -6.57 -0.34 1.99e-10 Extrinsic epigenetic age acceleration; CRC cis rs6500395 0.963 rs6500405 chr16:48690486 C/T cg04672837 chr16:48644449 N4BP1 -0.45 -6.63 -0.34 1.38e-10 Response to tocilizumab in rheumatoid arthritis; CRC cis rs4713675 0.565 rs9366828 chr6:33672798 G/A cg14003231 chr6:33640908 ITPR3 0.51 8.26 0.41 3.71e-15 Plateletcrit; CRC cis rs8180040 0.966 rs3816779 chr3:47543389 C/T cg10298567 chr3:47292165 KIF9 -0.35 -5.7 -0.3 2.71e-8 Colorectal cancer; CRC cis rs7615952 0.599 rs12486459 chr3:125741465 T/G cg02807482 chr3:125708958 NA -0.45 -5.65 -0.3 3.39e-8 Blood pressure (smoking interaction); CRC cis rs11122272 0.735 rs2250749 chr1:231485763 C/G cg06096015 chr1:231504339 EGLN1 0.38 5.88 0.31 1.01e-8 Hemoglobin concentration; CRC trans rs10983614 1.000 rs7867776 chr9:120072627 A/G cg07002965 chr16:88923228 GALNS;TRAPPC2L 0.45 6.13 0.32 2.58e-9 Survival in pancreatic cancer; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg06713521 chr6:7313605 SSR1 0.39 6.2 0.32 1.65e-9 Liver disease severity in Alagille syndrome; CRC cis rs7215564 0.818 rs35459747 chr17:78661475 T/C cg09596252 chr17:78655493 RPTOR 0.53 5.66 0.3 3.38e-8 Myopia (pathological); CRC cis rs561341 1.000 rs4795670 chr17:30244839 T/C cg19193384 chr17:30244184 NA -0.5 -6.62 -0.34 1.47e-10 Hip circumference adjusted for BMI; CRC cis rs1799949 1.000 rs16941 chr17:41244435 T/C cg19454999 chr17:41278357 BRCA1;NBR2 0.55 8.52 0.43 5.93e-16 Menopause (age at onset); CRC cis rs9914988 0.887 rs11650282 chr17:27090741 C/G cg20469991 chr17:27169893 C17orf63 -0.6 -7.26 -0.37 2.76e-12 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs3806843 0.735 rs2563335 chr5:140044292 A/C cg19875535 chr5:140030758 IK 0.64 10.57 0.5 1.08e-22 Depressive symptoms (multi-trait analysis); CRC cis rs801193 0.569 rs3846973 chr7:66120035 T/C cg12463550 chr7:65579703 CRCP -0.46 -6.16 -0.32 2.1e-9 Aortic root size; CRC cis rs9549328 0.699 rs2993345 chr13:113617086 C/T cg24588162 chr13:113633484 MCF2L 0.36 6.5 0.34 2.9e-10 Systolic blood pressure; CRC trans rs11722228 0.508 rs2241472 chr4:10085902 C/G cg26043149 chr18:55253948 FECH 1.12 17.14 0.69 1.7e-47 Gout;Urate levels;Serum uric acid levels; CRC cis rs6938 0.596 rs11072511 chr15:75159433 A/G cg05627522 chr15:75251581 NA 0.37 5.72 0.3 2.46e-8 Breast cancer; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg04407579 chr13:99228509 STK24 0.41 6.97 0.36 1.76e-11 Liver disease severity in Alagille syndrome; CRC cis rs372883 0.554 rs10154065 chr21:30749480 G/C cg08807101 chr21:30365312 RNF160 0.58 8.28 0.42 3.16e-15 Pancreatic cancer; CRC cis rs1728785 1.000 rs1094282 chr16:68577260 G/A cg02972257 chr16:68554789 NA -0.58 -7.23 -0.37 3.4e-12 Ulcerative colitis; CRC cis rs669446 0.562 rs3791036 chr1:44155383 A/G cg12908607 chr1:44402522 ARTN -0.34 -5.71 -0.3 2.47e-8 Amyotrophic lateral sclerosis (age of onset); CRC cis rs6500395 1.000 rs1039340 chr16:48574637 A/C cg04672837 chr16:48644449 N4BP1 0.44 6.55 0.34 2.2e-10 Response to tocilizumab in rheumatoid arthritis; CRC trans rs55675132 0.548 rs76034359 chr1:115375048 C/G cg25493687 chr8:27288214 PTK2B 0.5 6.06 0.32 3.77e-9 Schizophrenia; CRC cis rs4654899 0.802 rs935918 chr1:21145660 C/T cg02927042 chr1:21476669 EIF4G3 -0.53 -8.02 -0.4 1.82e-14 Superior frontal gyrus grey matter volume; CRC cis rs6893807 1.000 rs3814424 chr5:87968953 C/T cg09002922 chr5:87956389 LOC645323 -0.41 -5.69 -0.3 2.82e-8 Body mass index; CRC cis rs1538970 0.924 rs1826691 chr1:45881262 A/G cg05343316 chr1:45956843 TESK2 -0.7 -9.7 -0.47 9.61e-20 Platelet count; CRC cis rs72945132 0.769 rs3781645 chr11:70190374 T/C cg00319359 chr11:70116639 PPFIA1 0.65 7.24 0.37 3.14e-12 Coronary artery disease; CRC cis rs7224737 1.000 rs8070446 chr17:40285879 G/A cg02228675 chr17:40259724 DHX58 -0.5 -7.01 -0.36 1.38e-11 Fibrinogen levels; CRC cis rs4688759 0.719 rs73079018 chr3:49875327 T/C cg00383909 chr3:49044727 WDR6 1.38 12.37 0.56 3.96e-29 Blood protein levels; CRC cis rs910316 0.726 rs61979167 chr14:75663610 C/T cg03030879 chr14:75389066 RPS6KL1 0.41 6.24 0.33 1.35e-9 Height; CRC cis rs11628318 0.853 rs8003309 chr14:103050143 C/G cg12046867 chr14:103022105 NA -0.84 -11.52 -0.54 5.2e-26 Platelet count; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg09408520 chr2:157188965 NR4A2 0.46 6.03 0.32 4.5e-9 Thyroid stimulating hormone; CRC cis rs758324 0.812 rs601441 chr5:131284433 C/T cg25547332 chr5:131281432 NA -0.36 -5.85 -0.31 1.16e-8 Alzheimer's disease in APOE e4- carriers; CRC cis rs4665809 1.000 rs7573118 chr2:26308086 A/G cg22920501 chr2:26401640 FAM59B -0.53 -7.23 -0.37 3.4e-12 Gut microbiome composition (summer); CRC cis rs7107174 1.000 rs1006441 chr11:77932126 G/C cg02023728 chr11:77925099 USP35 0.48 7.33 0.37 1.79e-12 Testicular germ cell tumor; CRC cis rs7113874 0.610 rs10840055 chr11:8494345 C/T cg17679104 chr11:8615758 STK33 0.35 5.74 0.3 2.17e-8 Body mass index in physically active individuals;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs875971 0.798 rs12698522 chr7:65967341 T/C cg12463550 chr7:65579703 CRCP 0.46 6.29 0.33 9.97e-10 Aortic root size; CRC cis rs2976388 0.609 rs2717605 chr8:143801015 T/G cg04969067 chr8:143858791 LYNX1 0.44 7.44 0.38 8.59e-13 Urinary tract infection frequency; CRC cis rs2739330 0.828 rs5760108 chr22:24252668 G/T cg16132339 chr22:24313637 DDTL;DDT 0.64 10.39 0.5 4.75e-22 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs8177179 0.967 rs4078166 chr3:133435979 C/A cg17775713 chr3:133465469 TF 0.36 6.44 0.33 4.32e-10 Iron status biomarkers (transferrin levels); CRC cis rs1005277 0.522 rs289643 chr10:37941494 T/G cg25517755 chr10:38738941 LOC399744 -0.4 -5.73 -0.3 2.31e-8 Extrinsic epigenetic age acceleration; CRC cis rs713477 0.654 rs7143800 chr14:55917734 A/G cg13175173 chr14:55914753 NA -0.45 -7.99 -0.4 2.34e-14 Pediatric bone mineral content (femoral neck); CRC trans rs116095464 0.558 rs10057492 chr5:239503 T/C cg00938859 chr5:1591904 SDHAP3 0.74 7.92 0.4 3.68e-14 Breast cancer; CRC cis rs3806843 0.966 rs2563263 chr5:140137644 A/G cg19875535 chr5:140030758 IK 0.62 10.11 0.49 4.25e-21 Depressive symptoms (multi-trait analysis); CRC cis rs6088580 0.634 rs6088478 chr20:32971719 T/C cg24642439 chr20:33292090 TP53INP2 -0.38 -6.41 -0.33 5.08e-10 Glomerular filtration rate (creatinine); CRC cis rs5750830 0.649 rs5750808 chr22:39790987 G/A cg11247378 chr22:39784982 NA -0.44 -8.05 -0.41 1.48e-14 Intelligence (multi-trait analysis); CRC trans rs11039798 0.588 rs113800184 chr11:48756855 G/A cg15704280 chr7:45808275 SEPT13 0.66 6.81 0.35 4.72e-11 Axial length; CRC cis rs11948739 0.573 rs736046 chr5:130278613 A/G cg08523029 chr5:130500466 HINT1 0.49 6.19 0.32 1.83e-9 Pediatric bone mineral content (hip); CRC cis rs2153535 0.580 rs6902001 chr6:8477055 T/G cg07606381 chr6:8435919 SLC35B3 0.68 10.9 0.51 8.26e-24 Motion sickness; CRC cis rs611744 0.506 rs4735054 chr8:109261780 A/C cg18478394 chr8:109455254 TTC35 -0.39 -5.75 -0.3 2.09e-8 Dupuytren's disease; CRC cis rs1552244 0.816 rs13059144 chr3:10010197 A/C cg10729496 chr3:10149963 C3orf24 0.5 6.45 0.33 4.04e-10 Alzheimer's disease; CRC cis rs7614311 0.681 rs2241822 chr3:63965304 A/G cg22134162 chr3:63841271 THOC7 -0.57 -5.79 -0.3 1.63e-8 Lung function (FVC);Lung function (FEV1); CRC cis rs7772486 0.603 rs2223411 chr6:146028767 T/C cg13319975 chr6:146136371 FBXO30 0.63 9.16 0.45 5.77e-18 Lobe attachment (rater-scored or self-reported); CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg25599242 chr11:63304337 RARRES3 0.47 6.15 0.32 2.21e-9 Thyroid stimulating hormone; CRC cis rs1499614 1.000 rs2659903 chr7:66180931 G/A cg25985355 chr7:65971099 NA -0.52 -5.93 -0.31 7.56e-9 Gout; CRC cis rs977987 0.843 rs28558946 chr16:75489322 G/T cg03315344 chr16:75512273 CHST6 0.53 8.99 0.44 1.94e-17 Dupuytren's disease; CRC cis rs4363385 0.747 rs2339496 chr1:152970719 C/T cg25856811 chr1:152973957 SPRR3 -0.25 -6.8 -0.35 4.98e-11 Inflammatory skin disease; CRC cis rs600626 0.529 rs11236527 chr11:75469310 A/G cg24262691 chr11:75473276 NA -0.54 -8.39 -0.42 1.43e-15 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CRC cis rs7605827 0.836 rs2052436 chr2:15697518 T/C cg19274914 chr2:15703543 NA 0.37 5.62 0.3 4.13e-8 Educational attainment (years of education); CRC cis rs1005277 0.505 rs13503 chr10:38239843 C/A cg25427524 chr10:38739819 LOC399744 0.76 13.29 0.59 1.54e-32 Extrinsic epigenetic age acceleration; CRC cis rs9399135 0.935 rs2150680 chr6:135347131 G/C cg22676075 chr6:135203613 NA 0.41 6.38 0.33 5.97e-10 Red blood cell count; CRC cis rs9457247 0.602 rs2157388 chr6:167481912 G/A cg07741184 chr6:167504864 NA 0.43 7.2 0.37 4.2e-12 Crohn's disease; CRC cis rs7677751 0.747 rs1800809 chr4:55093914 A/G cg13615338 chr4:55094005 PDGFRA 0.4 5.8 0.3 1.57e-8 Corneal astigmatism; CRC cis rs919433 1.000 rs1346649 chr2:198166117 C/A cg10820045 chr2:198174542 NA -0.55 -11.04 -0.52 2.61e-24 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC cis rs12586317 0.508 rs10134914 chr14:35425012 T/G cg16230307 chr14:35515116 FAM177A1 0.66 8.52 0.43 5.97e-16 Psoriasis; CRC cis rs9303280 0.901 rs2952140 chr17:37928059 C/T cg11212589 chr17:38028394 ZPBP2 -0.43 -8.02 -0.4 1.92e-14 Self-reported allergy; CRC cis rs6598955 0.724 rs12726972 chr1:26639634 A/G cg04990556 chr1:26633338 UBXN11 0.66 10.86 0.51 1.09e-23 Obesity-related traits; CRC cis rs60871478 1.000 rs9195 chr7:825786 C/T cg04727924 chr7:799746 HEATR2 0.4 6.13 0.32 2.5e-9 Cerebrospinal P-tau181p levels; CRC cis rs951366 0.789 rs823094 chr1:205689807 G/T cg24503407 chr1:205819492 PM20D1 -0.8 -12.97 -0.58 2.36e-31 Menarche (age at onset); CRC cis rs12142240 0.698 rs68112720 chr1:46813888 T/C cg00530320 chr1:46809349 NSUN4 0.58 7.81 0.4 7.54e-14 Menopause (age at onset); CRC cis rs9868809 0.772 rs28452701 chr3:48708575 C/T cg07636037 chr3:49044803 WDR6 -0.64 -6.13 -0.32 2.5e-9 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; CRC cis rs7932354 0.528 rs4752967 chr11:47169376 T/C cg03339077 chr11:47165057 C11orf49 -0.47 -6.66 -0.34 1.12e-10 Bone mineral density (hip);Bone mineral density; CRC cis rs514406 0.929 rs1242224 chr1:53314887 G/A cg08859206 chr1:53392774 SCP2 -0.43 -6.86 -0.35 3.39e-11 Monocyte count; CRC cis rs853679 0.517 rs9380049 chr6:28048535 A/G cg03623178 chr6:28175578 NA 0.93 12.26 0.56 9.88e-29 Depression; CRC cis rs989128 0.600 rs9913430 chr17:48628470 A/T cg24438145 chr17:48624694 SPATA20 0.44 6.46 0.34 3.76e-10 Type 2 diabetes; CRC cis rs832540 0.618 rs41106 chr5:56145057 G/T cg24531977 chr5:56204891 C5orf35 -0.53 -7.89 -0.4 4.38e-14 Coronary artery disease; CRC trans rs61931739 0.534 rs11052973 chr12:34029708 A/G cg26384229 chr12:38710491 ALG10B 0.53 6.72 0.35 8.12e-11 Morning vs. evening chronotype; CRC cis rs853679 0.517 rs9357066 chr6:28129831 T/C cg02631126 chr6:28058918 ZSCAN12L1 0.29 5.91 0.31 8.38e-9 Depression; CRC cis rs10256972 0.681 rs12702016 chr7:1129392 C/T cg03188948 chr7:1209495 NA 0.44 6.3 0.33 9.51e-10 Longevity;Endometriosis; CRC cis rs11608355 0.515 rs11614551 chr12:109931630 G/A cg05360138 chr12:110035743 NA 0.76 8.5 0.42 6.78e-16 Neuroticism; CRC cis rs12024301 0.557 rs12061628 chr1:183653559 G/C cg11505048 chr1:183622726 RGL1;APOBEC4 0.71 6.24 0.33 1.33e-9 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs367943 0.966 rs444322 chr5:112815399 C/T cg12552261 chr5:112820674 MCC -0.49 -7.66 -0.39 2.06e-13 Type 2 diabetes; CRC cis rs3087591 1.000 rs7220483 chr17:29577248 G/A cg24425628 chr17:29625626 OMG;NF1 -0.86 -16.79 -0.68 4.09e-46 Hip circumference; CRC cis rs2294693 0.945 rs9369252 chr6:40986028 C/T cg14769373 chr6:40998127 UNC5CL 0.5 6.45 0.33 4.04e-10 Gastric cancer;Non-cardia gastric cancer; CRC cis rs747650 0.892 rs1976143 chr11:47225534 G/A cg03339077 chr11:47165057 C11orf49 0.46 6.51 0.34 2.85e-10 Acne (severe); CRC cis rs9814567 1.000 rs9826496 chr3:134224437 G/C cg06541857 chr3:134203789 ANAPC13;CEP63 -0.41 -6.23 -0.32 1.44e-9 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs2836974 0.863 rs8128026 chr21:40533702 T/C cg11644478 chr21:40555479 PSMG1 0.8 12.62 0.57 4.88e-30 Cognitive function; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg26114571 chr19:3225002 BRUNOL5 0.43 6.65 0.34 1.22e-10 Intelligence (multi-trait analysis); CRC cis rs1552244 1.000 rs6791810 chr3:10124444 A/G cg08888203 chr3:10149979 C3orf24 -0.74 -10.47 -0.5 2.57e-22 Alzheimer's disease; CRC cis rs13108904 0.517 rs13128825 chr4:1334007 G/A cg24560729 chr4:1342394 KIAA1530 0.38 6.14 0.32 2.36e-9 Obesity-related traits; CRC cis rs7662987 0.540 rs2851257 chr4:100039499 G/C cg13256891 chr4:100009986 ADH5 0.63 8.54 0.43 4.99e-16 Smoking initiation; CRC cis rs2652834 1.000 rs2652838 chr15:63396088 A/G cg05507819 chr15:63340323 TPM1 0.47 6.21 0.32 1.56e-9 HDL cholesterol; CRC cis rs4253772 0.550 rs9615913 chr22:46668515 A/T cg24881330 chr22:46731750 TRMU -0.62 -7.61 -0.39 2.98e-13 LDL cholesterol;Cholesterol, total; CRC cis rs7258465 0.931 rs8107347 chr19:18612748 G/A cg06462663 chr19:18546047 ISYNA1 0.46 7.04 0.36 1.15e-11 Breast cancer; CRC cis rs9902453 1.000 rs55971458 chr17:28427016 A/G cg26525008 chr17:28256777 EFCAB5;SSH2 0.59 8.79 0.44 8.21e-17 Coffee consumption (cups per day); CRC cis rs7666738 0.716 rs11721453 chr4:99045485 G/T cg05340658 chr4:99064831 C4orf37 0.6 9.35 0.46 1.36e-18 Colonoscopy-negative controls vs population controls; CRC cis rs7589728 0.925 rs80065975 chr2:88502758 G/A cg04511125 chr2:88470314 THNSL2 0.66 6.47 0.34 3.48e-10 Plasma clusterin levels; CRC cis rs919433 0.889 rs12472355 chr2:198205840 C/A cg10820045 chr2:198174542 NA -0.51 -8.89 -0.44 4.05e-17 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC cis rs9660180 0.934 rs34849348 chr1:1762757 C/T cg03396347 chr1:1875803 NA -0.6 -9.11 -0.45 8.23e-18 Body mass index; CRC cis rs12476592 0.602 rs174485 chr2:63857402 G/A cg10828910 chr2:63850056 LOC388955 0.49 6.09 0.32 3.15e-9 Childhood ear infection; CRC cis rs7814319 0.899 rs1878638 chr8:97258719 C/T cg20787634 chr8:97240163 UQCRB -0.55 -9.53 -0.47 3.53e-19 Lung function (FVC); CRC cis rs929596 0.793 rs2602376 chr2:234582051 C/T cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.56 -7.85 -0.4 5.81e-14 Total bilirubin levels in HIV-1 infection; CRC cis rs9487051 0.714 rs9487058 chr6:109631060 A/C cg12927641 chr6:109611667 NA -0.36 -6.38 -0.33 6.1e-10 Reticulocyte fraction of red cells; CRC cis rs916888 0.697 rs199516 chr17:44856485 C/T cg17911788 chr17:44343683 NA 0.57 6.98 0.36 1.59e-11 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs2223471 0.719 rs9357673 chr6:50779653 C/T cg03432817 chr6:50765336 NA 0.37 5.8 0.3 1.58e-8 Subcutaneous adipose tissue; CRC cis rs3018066 0.748 rs80076579 chr4:106991115 A/T cg01869342 chr4:106983673 TBCK 0.44 6.71 0.35 8.61e-11 Cancer; CRC cis rs7202877 0.656 rs247427 chr16:75439132 T/C cg03315344 chr16:75512273 CHST6 -0.51 -5.9 -0.31 8.84e-9 Type 2 diabetes;Type 1 diabetes; CRC cis rs600231 0.665 rs1784858 chr11:65222952 T/C cg17120908 chr11:65337727 SSSCA1 -0.55 -8.14 -0.41 8.07e-15 Bone mineral density; CRC cis rs6685188 0.920 rs6593964 chr1:205662337 G/T cg07157834 chr1:205819609 PM20D1 0.42 5.82 0.31 1.37e-8 White blood cell count (basophil);Basophil percentage of white cells; CRC cis rs1847505 0.609 rs1514541 chr13:61586096 C/G cg14094164 chr13:61491000 NA 0.42 9.41 0.46 8.67e-19 Polychlorinated biphenyl levels; CRC cis rs11212617 0.967 rs662578 chr11:108194557 C/T cg01991180 chr11:108092276 ATM;NPAT 0.42 6.25 0.33 1.27e-9 Response to metformin in type 2 diabetes (glycemic); CRC cis rs4716602 0.542 rs10249935 chr7:156159781 G/A cg16983916 chr7:156159713 NA -0.4 -6.92 -0.36 2.41e-11 Anti-saccade response; CRC cis rs9322193 0.962 rs10872653 chr6:150100043 A/C cg07701084 chr6:150067640 NUP43 0.47 6.61 0.34 1.51e-10 Lung cancer; CRC cis rs6738485 0.507 rs66569888 chr2:106886967 G/A cg15412446 chr2:106886593 NA -0.6 -8.81 -0.44 7.3e-17 Pursuit maintenance gain;Pursuit maintenance gain in psychotic disorders; CRC cis rs7659604 1.000 rs7660078 chr4:122665577 G/T cg06713675 chr4:122721982 EXOSC9 -0.4 -6.56 -0.34 2.05e-10 Type 2 diabetes; CRC cis rs7274811 0.744 rs209677 chr20:32140287 C/T cg07470512 chr20:32255052 NECAB3;C20orf134 0.48 6.56 0.34 2.06e-10 Height; CRC cis rs13161895 0.941 rs3797764 chr5:179439345 A/G cg02702477 chr5:179499311 RNF130 -0.56 -6.48 -0.34 3.35e-10 LDL cholesterol; CRC cis rs875971 0.545 rs6961853 chr7:66002022 G/A cg11764359 chr7:65958608 NA 0.46 5.79 0.3 1.6e-8 Aortic root size; CRC cis rs7786808 0.782 rs7787923 chr7:158227312 A/G cg15440763 chr7:158190612 PTPRN2 0.34 5.61 0.3 4.2e-8 Obesity-related traits; CRC cis rs6968419 0.747 rs1004109 chr7:115862296 A/T cg02561103 chr7:115862891 TES 0.43 6.61 0.34 1.54e-10 Intraocular pressure; CRC cis rs12479064 0.724 rs10496336 chr2:99996165 A/G cg14399236 chr2:99771627 LIPT1;TSGA10 -0.56 -6.69 -0.35 9.63e-11 Chronic sinus infection; CRC cis rs34172651 0.517 rs11647120 chr16:24819806 A/G cg02428538 chr16:24856791 SLC5A11 -0.53 -6.2 -0.32 1.66e-9 Intelligence (multi-trait analysis); CRC cis rs11722228 1.000 rs6825187 chr4:9915325 T/C cg11266682 chr4:10021025 SLC2A9 -0.4 -6.78 -0.35 5.61e-11 Gout;Urate levels;Serum uric acid levels; CRC trans rs561341 1.000 rs508192 chr17:30315147 C/T cg27661571 chr11:113659931 NA 0.88 9.84 0.48 3.5e-20 Hip circumference adjusted for BMI; CRC trans rs1814175 0.817 rs10839318 chr11:49657511 G/C cg11707556 chr5:10655725 ANKRD33B -0.42 -7.79 -0.39 9.04e-14 Height; CRC cis rs1568889 0.838 rs10835273 chr11:28156598 T/C cg06544937 chr11:28130018 METT5D1;KIF18A 0.92 15.5 0.65 4.47e-41 Bipolar disorder; CRC cis rs9916302 0.904 rs11654018 chr17:37703740 C/T cg07936489 chr17:37558343 FBXL20 0.84 13.33 0.59 1.03e-32 Glomerular filtration rate (creatinine); CRC cis rs7119 0.717 rs11629835 chr15:77787469 G/T cg05673287 chr15:77411982 SGK269 -0.53 -8.14 -0.41 8.13e-15 Type 2 diabetes; CRC cis rs6662572 0.737 rs11211247 chr1:46476587 G/T cg08644498 chr1:46502608 NA 0.44 7.05 0.36 1.07e-11 Blood protein levels; CRC cis rs9467711 0.606 rs2393667 chr6:26421345 T/C cg08501292 chr6:25962987 TRIM38 0.79 6.17 0.32 2e-9 Autism spectrum disorder or schizophrenia; CRC cis rs9486715 0.867 rs9480700 chr6:96965056 A/G cg18709589 chr6:96969512 KIAA0776 0.49 7.2 0.37 4.01e-12 Headache; CRC cis rs9409565 0.855 rs7042481 chr9:97064273 C/A cg04523069 chr9:97136363 HIATL1 -0.4 -6.01 -0.31 5.04e-9 Colorectal cancer (alcohol consumption interaction); CRC cis rs12701220 0.901 rs12701710 chr7:1090396 A/G cg02869364 chr7:1081709 C7orf50 0.44 5.73 0.3 2.31e-8 Bronchopulmonary dysplasia; CRC cis rs4332037 0.707 rs11763813 chr7:1896690 C/T cg25834613 chr7:1915315 MAD1L1 -0.43 -6.3 -0.33 9.36e-10 Bipolar disorder; CRC cis rs6547741 0.816 rs10201652 chr2:27874332 A/C cg27432699 chr2:27873401 GPN1 -0.82 -15.72 -0.65 6.47e-42 Oral cavity cancer; CRC cis rs6840360 0.642 rs6855845 chr4:152417380 A/G cg09659197 chr4:152720779 NA 0.33 6.54 0.34 2.34e-10 Intelligence (multi-trait analysis); CRC cis rs7224685 0.501 rs2676276 chr17:3919981 C/T cg09597638 chr17:3907349 NA -0.62 -11.72 -0.54 9.55e-27 Type 2 diabetes; CRC cis rs1707322 1.000 rs7539800 chr1:46262129 C/G cg06784218 chr1:46089804 CCDC17 -0.59 -10.73 -0.51 3.06e-23 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs7258465 1.000 rs2278238 chr19:18576484 T/C cg01065977 chr19:18549689 ISYNA1 -0.41 -6.39 -0.33 5.59e-10 Breast cancer; CRC cis rs9381040 0.610 rs2235678 chr6:41020510 G/T cg04346459 chr6:41068666 NFYA;LOC221442 -0.41 -6.2 -0.32 1.67e-9 Alzheimer's disease (late onset); CRC cis rs67340775 0.541 rs200965 chr6:27866384 G/A cg15845792 chr6:28175446 NA 0.89 9.2 0.45 4.22e-18 Lung cancer in ever smokers; CRC cis rs6540556 0.769 rs6665715 chr1:209931353 A/C cg23920097 chr1:209922102 NA 0.53 6.48 0.34 3.43e-10 Red blood cell count; CRC cis rs1577917 0.696 rs10806334 chr6:86439329 T/A cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.6 -8.51 -0.42 6.45e-16 Response to antipsychotic treatment; CRC cis rs727505 0.721 rs67277928 chr7:124776704 G/T cg23710748 chr7:124431027 NA -0.64 -11.39 -0.53 1.5e-25 Lewy body disease; CRC cis rs8060686 0.623 rs56303487 chr16:68029739 C/T cg09835421 chr16:68378352 PRMT7 -0.5 -5.83 -0.31 1.33e-8 HDL cholesterol;Metabolic syndrome; CRC cis rs1568889 1.000 rs12797155 chr11:28290866 A/T cg06544937 chr11:28130018 METT5D1;KIF18A 0.78 10.98 0.52 4.29e-24 Bipolar disorder; CRC cis rs755249 0.567 rs4660636 chr1:39770227 T/C cg18385671 chr1:39797026 MACF1 -0.42 -5.98 -0.31 5.94e-9 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs4363385 0.818 rs57311099 chr1:153005597 A/C cg25856811 chr1:152973957 SPRR3 -0.25 -6.99 -0.36 1.51e-11 Inflammatory skin disease; CRC cis rs7580658 0.864 rs4150441 chr2:128040915 T/C cg09760422 chr2:128146352 NA -0.3 -5.99 -0.31 5.43e-9 Protein C levels; CRC cis rs1218582 0.772 rs1109815 chr1:154909268 A/G cg09359103 chr1:154839909 KCNN3 -0.69 -11.99 -0.55 1.04e-27 Prostate cancer; CRC cis rs8060686 0.920 rs112894876 chr16:67812039 G/C cg26727032 chr16:67993705 SLC12A4 -0.6 -6.97 -0.36 1.69e-11 HDL cholesterol;Metabolic syndrome; CRC cis rs7618915 0.547 rs35211965 chr3:52685305 C/G cg18099408 chr3:52552593 STAB1 -0.44 -7.16 -0.37 5.27e-12 Bipolar disorder; CRC cis rs7267979 0.718 rs2983489 chr20:25244120 C/A cg24626310 chr20:25276739 ABHD12;PYGB 0.35 5.8 0.3 1.56e-8 Liver enzyme levels (alkaline phosphatase); CRC cis rs7493 0.950 rs6961624 chr7:95037661 T/C cg20119798 chr7:94954144 PON1 -0.48 -6.19 -0.32 1.83e-9 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs4481887 0.927 rs4534422 chr1:248479482 A/G cg00666640 chr1:248458726 OR2T12 0.48 8.18 0.41 6.14e-15 Common traits (Other); CRC cis rs9487051 0.652 rs13210424 chr6:109598737 G/A cg12927641 chr6:109611667 NA -0.36 -6.35 -0.33 7.26e-10 Reticulocyte fraction of red cells; CRC cis rs7666738 0.830 rs6823718 chr4:99063202 C/T cg05340658 chr4:99064831 C4orf37 0.6 9.38 0.46 1.1e-18 Colonoscopy-negative controls vs population controls; CRC cis rs59901009 0.911 rs61192802 chr11:10200742 A/G cg23875677 chr11:10229755 SBF2 -0.47 -5.84 -0.31 1.25e-8 Hematocrit;Hemoglobin concentration; CRC cis rs79839061 0.656 rs11726912 chr4:887868 A/C cg14530993 chr4:882597 GAK 0.79 7.79 0.39 8.83e-14 Intelligence (multi-trait analysis); CRC cis rs798554 0.660 rs2644295 chr7:2860217 A/C cg13628971 chr7:2884303 GNA12 0.38 5.75 0.3 2.07e-8 Height; CRC cis rs7208859 0.673 rs12103759 chr17:29235687 G/A cg01831904 chr17:28903510 LRRC37B2 -0.56 -5.83 -0.31 1.35e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs897984 0.806 rs11640534 chr16:30949515 G/A cg00531865 chr16:30841666 NA 0.5 7.1 0.36 7.91e-12 Dementia with Lewy bodies; CRC cis rs6665290 0.904 rs6426559 chr1:227195876 T/C cg10327440 chr1:227177885 CDC42BPA -1.04 -23.33 -0.79 9.69e-72 Myeloid white cell count; CRC cis rs9303280 0.901 rs883770 chr17:38063381 C/T cg17344932 chr17:38183730 MED24;SNORD124 0.37 5.82 0.31 1.42e-8 Self-reported allergy; CRC cis rs6681460 0.866 rs1856318 chr1:67024215 T/C cg02459107 chr1:67143332 SGIP1 0.46 7.36 0.38 1.45e-12 Presence of antiphospholipid antibodies; CRC cis rs73198271 0.530 rs11778326 chr8:8651566 T/G cg01851573 chr8:8652454 MFHAS1 0.56 7.08 0.36 8.86e-12 Bone ultrasound measurement (broadband ultrasound attenuation); CRC cis rs6502050 0.835 rs3088177 chr17:80111724 A/G cg11859384 chr17:80120422 CCDC57 -0.37 -5.88 -0.31 1.03e-8 Life satisfaction; CRC cis rs9291683 0.546 rs13129453 chr4:10044784 T/C cg11266682 chr4:10021025 SLC2A9 0.52 10.62 0.51 7.35e-23 Bone mineral density; CRC cis rs7267979 0.816 rs376742 chr20:25487417 A/C cg24626310 chr20:25276739 ABHD12;PYGB 0.32 5.64 0.3 3.76e-8 Liver enzyme levels (alkaline phosphatase); CRC trans rs3733585 0.783 rs13148371 chr4:10032561 C/T cg26043149 chr18:55253948 FECH 0.53 8.09 0.41 1.13e-14 Cleft plate (environmental tobacco smoke interaction); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg25330514 chr12:110152300 C12orf34 0.41 6.41 0.33 5.14e-10 Liver disease severity in Alagille syndrome; CRC cis rs1348850 0.567 rs3770011 chr2:178537890 C/T cg22681709 chr2:178499509 PDE11A -0.44 -8.11 -0.41 1.02e-14 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg03584783 chr1:173836803 GAS5;SNORD76;SNORD75;SNORD77;ZBTB37 0.42 6.76 0.35 6.2e-11 Liver disease severity in Alagille syndrome; CRC cis rs8031584 0.672 rs17815726 chr15:31313252 C/G cg14829155 chr15:31115871 NA 0.46 5.89 0.31 9.39e-9 Huntington's disease progression; CRC cis rs3617 0.559 rs11915546 chr3:52866845 A/C cg18099408 chr3:52552593 STAB1 0.35 6.03 0.32 4.48e-9 Red blood cell count;Autism spectrum disorder or schizophrenia; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg21365899 chr1:231558446 EGLN1 0.41 6.02 0.31 4.62e-9 Intelligence (multi-trait analysis); CRC cis rs2976388 0.632 rs2585139 chr8:143808175 C/G cg04969067 chr8:143858791 LYNX1 0.45 7.66 0.39 2.15e-13 Urinary tract infection frequency; CRC cis rs6479527 0.806 rs1592153 chr9:96745836 A/C cg14459158 chr9:96720562 NA 0.41 7.36 0.38 1.5e-12 Esophageal adenocarcinoma; CRC cis rs62432291 0.681 rs294913 chr6:159667227 G/A cg14500486 chr6:159655392 FNDC1 -0.74 -9.0 -0.44 1.91e-17 Joint mobility (Beighton score); CRC cis rs7945705 0.935 rs1883098 chr11:8890594 G/A cg14711859 chr11:8959438 ASCL3 0.45 7.61 0.39 2.88e-13 Hemoglobin concentration; CRC cis rs875971 0.862 rs10261398 chr7:65750164 A/G cg18876405 chr7:65276391 NA -0.5 -8.29 -0.42 2.87e-15 Aortic root size; CRC cis rs6424115 0.679 rs2267961 chr1:24071048 A/G cg10978503 chr1:24200527 CNR2 -0.43 -6.43 -0.33 4.56e-10 Immature fraction of reticulocytes; CRC cis rs31872 0.520 rs246053 chr5:140326290 T/A cg19875535 chr5:140030758 IK 0.39 6.02 0.31 4.67e-9 Visceral adipose tissue adjusted for BMI; CRC cis rs2717559 0.522 rs10956987 chr8:143886613 T/C cg12516270 chr8:143859308 LYNX1 -0.7 -13.14 -0.59 5.43e-32 Urinary tract infection frequency; CRC cis rs7552404 1.000 rs7524467 chr1:76194054 C/G cg10523679 chr1:76189770 ACADM 0.85 11.74 0.54 8.26e-27 Blood metabolite levels;Acylcarnitine levels; CRC cis rs9916302 0.800 rs8069451 chr17:37504933 C/T cg15445000 chr17:37608096 MED1 0.42 9.25 0.45 2.97e-18 Glomerular filtration rate (creatinine); CRC cis rs8060686 0.920 rs73591968 chr16:67803063 G/A cg10544611 chr16:67998164 SLC12A4 -0.53 -5.64 -0.3 3.66e-8 HDL cholesterol;Metabolic syndrome; CRC cis rs887829 0.570 rs10168333 chr2:234596988 C/T cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.47 -7.31 -0.37 2.04e-12 Metabolic traits;Bilirubin levels;Cholelithiasis-related traits in sickle cell anemia;Metabolite levels;Total bilirubin levels in HIV-1 infection;Serum metabolite levels;Blood metabolite levels; CRC cis rs13191362 1.000 rs34066731 chr6:163011047 A/G cg21926612 chr6:163149169 PACRG;PARK2 0.78 10.8 0.51 1.77e-23 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs7927592 0.913 rs6591340 chr11:68297636 A/G cg16797656 chr11:68205561 LRP5 0.37 5.89 0.31 9.67e-9 Total body bone mineral density; CRC trans rs10983614 1.000 rs7867776 chr9:120072627 A/G cg01774158 chr5:133562094 PPP2CA 0.44 6.0 0.31 5.27e-9 Survival in pancreatic cancer; CRC cis rs7119 0.717 rs12916515 chr15:77818518 G/T cg27398640 chr15:77910606 LINGO1 -0.43 -7.42 -0.38 1.03e-12 Type 2 diabetes; CRC cis rs13064411 0.696 rs6766615 chr3:113219342 T/C cg10517650 chr3:113235015 CCDC52 -0.41 -7.21 -0.37 3.77e-12 Response to simvastatin treatment (PCSK9 protein level change); CRC cis rs6066835 1.000 rs6066820 chr20:47318444 T/C cg18078177 chr20:47281410 PREX1 0.68 5.67 0.3 3.09e-8 Multiple myeloma; CRC cis rs11785400 0.793 rs4467920 chr8:143736846 C/T cg10596483 chr8:143751796 JRK 0.43 5.81 0.3 1.51e-8 Schizophrenia; CRC cis rs875971 0.545 rs2279757 chr7:65828663 T/C cg03233332 chr7:66118400 NA -0.43 -5.87 -0.31 1.05e-8 Aortic root size; CRC trans rs72956618 1.000 rs68160031 chr2:207489365 T/G cg20754261 chr2:468330 NA -0.63 -6.09 -0.32 3.22e-9 Tonsillectomy; CRC trans rs61931739 0.500 rs11053249 chr12:34518834 A/T cg26384229 chr12:38710491 ALG10B 0.65 8.64 0.43 2.45e-16 Morning vs. evening chronotype; CRC cis rs12477438 0.798 rs1453562 chr2:99615850 G/A cg14399236 chr2:99771627 LIPT1;TSGA10 -0.74 -10.4 -0.5 4.36e-22 Chronic sinus infection; CRC cis rs8005677 0.828 rs12589539 chr14:23396680 A/G cg01529538 chr14:23388837 RBM23 0.39 5.92 0.31 7.93e-9 Cognitive ability (multi-trait analysis); CRC cis rs3790844 1.000 rs3790844 chr1:200007432 A/G cg13229857 chr1:200006247 NR5A2 0.6 8.59 0.43 3.62e-16 Pancreatic cancer; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg05935374 chr11:82782929 RAB30 0.47 6.15 0.32 2.3e-9 Thyroid stimulating hormone; CRC trans rs2235573 0.527 rs139878 chr22:38361559 C/T cg19894588 chr14:64061835 NA 0.52 7.29 0.37 2.4e-12 Glioblastoma;Glioma; CRC cis rs9914988 0.832 rs11650788 chr17:27174523 T/A cg12682573 chr17:27188876 MIR451;MIR144 0.59 8.33 0.42 2.24e-15 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs1707322 0.613 rs1473840 chr1:46601197 A/G cg06784218 chr1:46089804 CCDC17 -0.51 -8.24 -0.41 4.07e-15 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs9549260 0.755 rs9532571 chr13:41218670 C/T cg21288729 chr13:41239152 FOXO1 0.45 6.99 0.36 1.53e-11 Red blood cell count; CRC cis rs921968 0.613 rs2710251 chr2:219543433 T/C cg02176678 chr2:219576539 TTLL4 -0.44 -6.95 -0.36 1.99e-11 Mean corpuscular hemoglobin concentration; CRC cis rs736408 0.609 rs2230534 chr3:52802402 A/C cg15147215 chr3:52552868 STAB1 -0.63 -10.21 -0.49 1.89e-21 Bipolar disorder; CRC cis rs16973500 0.808 rs72801797 chr16:71975300 A/G cg00732059 chr16:71740210 PHLPP2 -0.65 -6.72 -0.35 7.98e-11 Response to anti-TNF therapy in rheumatoid arthritis;Attention deficit hyperactivity disorder and conduct disorder; CRC cis rs55794721 0.509 rs2982358 chr1:25745204 G/T cg20684491 chr1:25596433 NA 0.41 7.08 0.36 8.54e-12 Plateletcrit;Mean corpuscular volume; CRC cis rs11112613 0.713 rs73184083 chr12:105952593 T/A cg03607813 chr12:105948248 NA 0.78 10.91 0.52 7.6e-24 Corrected insulin response;Corrected insulin response adjusted for insulin sensitivity index; CRC cis rs11677416 1.000 rs3783559 chr2:113529837 A/G cg27083787 chr2:113543245 IL1A 0.46 6.58 0.34 1.89e-10 Response to antipsychotic treatment in schizophrenia (working memory); CRC trans rs17607347 0.738 rs8056067 chr16:72347401 G/C cg27230510 chr3:50404023 CACNA2D2 -0.53 -6.01 -0.31 4.87e-9 Intelligence (multi-trait analysis); CRC cis rs67478160 0.619 rs11623546 chr14:104269098 A/G cg08213375 chr14:104286397 PPP1R13B 0.63 12.91 0.58 4.04e-31 Schizophrenia; CRC cis rs1348850 0.874 rs12996447 chr2:178283592 C/T cg22681709 chr2:178499509 PDE11A -0.34 -6.37 -0.33 6.26e-10 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs7512552 0.839 rs17597088 chr1:150475772 A/G cg15654264 chr1:150340011 RPRD2 0.6 8.4 0.42 1.35e-15 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); CRC cis rs4555082 0.830 rs2735812 chr14:105727575 A/G cg18132624 chr14:105716052 BTBD6;BRF1 -0.46 -7.37 -0.38 1.36e-12 Mean platelet volume;Platelet distribution width; CRC cis rs10256972 0.521 rs871019 chr7:1105230 A/G cg18402987 chr7:1209562 NA 0.43 6.66 0.34 1.18e-10 Longevity;Endometriosis; CRC cis rs78456975 0.622 rs11888851 chr2:1518254 C/G cg12573674 chr2:1569213 NA -0.62 -7.23 -0.37 3.41e-12 Placebo response in major depressive disorder (% change in symptom score); CRC cis rs3820068 0.581 rs72645879 chr1:15928199 A/G cg24675056 chr1:15929824 NA 0.49 6.77 0.35 5.87e-11 Systolic blood pressure; CRC cis rs6901004 0.570 rs783084 chr6:111477887 T/C cg15721981 chr6:111408429 SLC16A10 0.52 6.6 0.34 1.66e-10 Blood metabolite levels; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg16098923 chr2:88927231 EIF2AK3 0.39 6.44 0.33 4.13e-10 Liver disease severity in Alagille syndrome; CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg19419581 chr17:79482410 NA -0.55 -6.81 -0.35 4.7e-11 Diisocyanate-induced asthma; CRC cis rs13118159 0.801 rs1128427 chr4:1330759 T/C cg19318889 chr4:1322082 MAEA 0.53 7.75 0.39 1.15e-13 Longevity; CRC trans rs11098499 0.866 rs12513310 chr4:120288039 T/A cg25214090 chr10:38739885 LOC399744 0.61 9.66 0.47 1.39e-19 Corneal astigmatism; CRC cis rs736801 0.780 rs11951091 chr5:131786595 G/A cg21138405 chr5:131827807 IRF1 -0.38 -6.58 -0.34 1.84e-10 Breast cancer;Mosquito bite size; CRC cis rs10193935 0.901 rs6752455 chr2:42543577 A/C cg27598129 chr2:42591480 NA -0.65 -7.61 -0.39 2.98e-13 Colonoscopy-negative controls vs population controls; CRC trans rs7615952 0.800 rs35390120 chr3:125599809 G/A cg07211511 chr3:129823064 LOC729375 -1.08 -13.72 -0.6 3.4e-34 Blood pressure (smoking interaction); CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg16176301 chr11:8933372 ST5;C11orf17 0.54 7.07 0.36 9.46e-12 Thyroid stimulating hormone; CRC cis rs3018066 0.666 rs28866820 chr4:107031077 T/C cg01869342 chr4:106983673 TBCK 0.45 5.9 0.31 8.95e-9 Cancer; CRC cis rs1448094 0.512 rs61930861 chr12:86245023 G/T cg19622623 chr12:86230825 RASSF9 -0.41 -6.7 -0.35 9.04e-11 Major depressive disorder; CRC cis rs3806843 0.868 rs2531342 chr5:140130612 C/T cg16607685 chr5:140181889 PCDHA2;PCDHA1;PCDHA3 0.27 6.11 0.32 2.75e-9 Depressive symptoms (multi-trait analysis); CRC cis rs1552244 0.882 rs2130813 chr3:10038706 A/C cg08888203 chr3:10149979 C3orf24 0.64 8.64 0.43 2.5e-16 Alzheimer's disease; CRC cis rs2617583 0.530 rs10060889 chr5:1456803 A/G cg07148919 chr5:1466943 LPCAT1 -0.43 -5.81 -0.31 1.44e-8 Breast cancer; CRC cis rs8141529 0.748 rs2064261 chr22:29287730 C/T cg15103426 chr22:29168792 CCDC117 0.47 6.55 0.34 2.27e-10 Lymphocyte counts; CRC cis rs644799 0.965 rs549695 chr11:95617788 T/C cg25478527 chr11:95522999 CEP57;FAM76B 0.5 7.4 0.38 1.13e-12 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs3740540 0.530 rs2362507 chr10:126290820 A/G cg04949429 chr10:126290192 LHPP 0.43 6.35 0.33 7.13e-10 Obesity-related traits;Acute lymphoblastic leukemia (childhood); CRC cis rs9463078 0.804 rs9463081 chr6:45233108 G/A cg25276700 chr6:44698697 NA -0.27 -6.49 -0.34 3.07e-10 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; CRC cis rs775227 1.000 rs66518523 chr3:113004759 G/T cg18753928 chr3:113234510 CCDC52 -0.49 -6.16 -0.32 2.09e-9 Dental caries; CRC cis rs9818758 0.607 rs66991555 chr3:49228643 A/G cg00383909 chr3:49044727 WDR6 1.09 11.1 0.52 1.52e-24 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; CRC cis rs10992471 0.603 rs4744141 chr9:95352140 T/C cg14631576 chr9:95140430 CENPP -0.37 -6.42 -0.33 4.74e-10 Visceral adipose tissue/subcutaneous adipose tissue ratio; CRC cis rs3204270 0.759 rs8065104 chr17:79672605 G/A cg18367735 chr17:79674897 NA 0.54 6.15 0.32 2.25e-9 Dental caries; CRC cis rs7546094 1.000 rs3013440 chr1:113195789 G/A cg22162597 chr1:113214053 CAPZA1 -0.42 -5.75 -0.3 2.04e-8 Platelet distribution width; CRC cis rs875971 0.545 rs316316 chr7:65614257 C/T cg02869306 chr7:64672164 INTS4L1 0.43 6.36 0.33 6.93e-10 Aortic root size; CRC cis rs17209837 1.000 rs17149640 chr7:87086039 A/C cg00919237 chr7:87102261 ABCB4 -0.49 -6.03 -0.32 4.4e-9 Gallbladder cancer; CRC cis rs1552244 1.000 rs33917318 chr3:10067797 T/C cg13047869 chr3:10149882 C3orf24 0.52 7.13 0.37 6.56e-12 Alzheimer's disease; CRC cis rs9818758 0.607 rs66991555 chr3:49228643 A/G cg07636037 chr3:49044803 WDR6 -0.66 -5.85 -0.31 1.18e-8 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; CRC cis rs9649213 0.574 rs7791321 chr7:97944125 G/C cg00277769 chr7:97922759 BAIAP2L1 -0.61 -10.6 -0.5 8.74e-23 Prostate cancer (SNP x SNP interaction); CRC cis rs1519814 0.956 rs7827008 chr8:121130281 A/T cg22335954 chr8:121166405 COL14A1 -0.49 -6.03 -0.32 4.52e-9 Breast cancer; CRC cis rs514406 0.893 rs476108 chr1:53317351 C/T cg27535305 chr1:53392650 SCP2 -0.37 -6.75 -0.35 6.5500000000000006e-11 Monocyte count; CRC cis rs6496667 0.558 rs61653706 chr15:91076654 G/A cg04176472 chr15:90893244 GABARAPL3 0.48 7.26 0.37 2.75e-12 Rheumatoid arthritis; CRC cis rs950169 0.840 rs2896002 chr15:84945121 A/G cg11189052 chr15:85197271 WDR73 0.63 8.8 0.44 7.65e-17 Schizophrenia; CRC cis rs317689 0.513 rs317678 chr12:69692166 C/G cg14784868 chr12:69753453 YEATS4 0.63 9.62 0.47 1.84e-19 Response to diuretic therapy; CRC cis rs2576037 0.526 rs4258717 chr18:44456954 T/C cg24750912 chr18:44543259 TCEB3CL;KATNAL2 0.29 5.9 0.31 9.05e-9 Personality dimensions; CRC cis rs1552244 0.882 rs13063098 chr3:10009919 G/A cg08888203 chr3:10149979 C3orf24 0.65 8.77 0.44 9.52e-17 Alzheimer's disease; CRC trans rs9291683 0.538 rs11727199 chr4:10036190 C/T cg26043149 chr18:55253948 FECH 0.53 8.17 0.41 6.8e-15 Bone mineral density; CRC cis rs6502050 0.835 rs11654584 chr17:80079435 A/T cg02741985 chr17:80059408 CCDC57 0.45 7.31 0.37 2.08e-12 Life satisfaction; CRC cis rs1223397 0.938 rs3817742 chr6:13279552 T/C cg07912922 chr6:13274314 PHACTR1 0.5 6.18 0.32 1.87e-9 Blood pressure; CRC cis rs1448094 0.558 rs7485285 chr12:86483641 G/A cg02569458 chr12:86230093 RASSF9 -0.42 -7.11 -0.36 7.39e-12 Major depressive disorder; CRC cis rs7680126 0.596 rs12503603 chr4:10313757 T/G cg11266682 chr4:10021025 SLC2A9 -0.5 -7.25 -0.37 2.95e-12 Urate levels in lean individuals;Urate levels in overweight individuals;Urate levels in obese individuals; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg01517273 chr1:154599968 ADAR 0.43 5.99 0.31 5.63e-9 Response to antipsychotic treatment; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg15539395 chr19:59086703 MGC2752 0.46 6.75 0.35 6.78e-11 Intelligence (multi-trait analysis); CRC cis rs1218582 0.772 rs2102423 chr1:154916068 A/G cg03351412 chr1:154909251 PMVK 0.53 8.38 0.42 1.59e-15 Prostate cancer; CRC cis rs6460942 1.000 rs6948314 chr7:12418363 T/A cg10578991 chr7:12443926 VWDE -0.5 -5.98 -0.31 5.94e-9 Coronary artery disease; CRC cis rs7833986 0.534 rs10504198 chr8:57006254 G/C cg23139584 chr8:56987506 RPS20;SNORD54 0.91 12.38 0.56 3.79e-29 Height; CRC cis rs9303401 0.614 rs3887355 chr17:56538639 T/C cg10487724 chr17:56770010 TEX14;RAD51C 0.77 9.53 0.47 3.55e-19 Cognitive test performance; CRC cis rs4077515 0.504 rs10870164 chr9:139315682 C/T cg14019695 chr9:139328340 INPP5E -0.39 -5.9 -0.31 9.06e-9 Ulcerative colitis;IgA nephropathy;Inflammatory bowel disease;Crohn's disease; CRC cis rs11122272 0.735 rs2808580 chr1:231509259 A/G cg06096015 chr1:231504339 EGLN1 0.4 5.95 0.31 6.7e-9 Hemoglobin concentration; CRC cis rs6866344 0.601 rs4419608 chr5:178097049 C/T cg03877680 chr5:178157825 ZNF354A 0.62 7.91 0.4 3.84e-14 Neutrophil percentage of white cells; CRC cis rs9611519 0.590 rs4821980 chr22:41415479 C/G cg03806693 chr22:41940476 POLR3H -0.4 -5.73 -0.3 2.26e-8 Neuroticism; CRC cis rs7705042 0.828 rs7737631 chr5:141506615 T/G cg07392085 chr5:141489673 NDFIP1 0.45 6.97 0.36 1.69e-11 Asthma; CRC cis rs13256369 0.951 rs13259955 chr8:8565885 C/G cg00074818 chr8:8560427 CLDN23 0.38 6.93 0.36 2.2e-11 Obesity-related traits; CRC cis rs634534 0.591 rs688862 chr11:65733393 A/G cg26695010 chr11:65641043 EFEMP2 -0.4 -6.15 -0.32 2.22e-9 Sum eosinophil basophil counts;Eosinophil counts; CRC cis rs9837602 0.938 rs17393059 chr3:99761908 A/G cg07805332 chr3:99536008 MIR548G;C3orf26 -0.51 -6.91 -0.36 2.47e-11 Breast cancer; CRC cis rs798554 0.721 rs2527680 chr7:2892361 C/T cg04166393 chr7:2884313 GNA12 0.56 7.41 0.38 1.07e-12 Height; CRC cis rs1862618 0.756 rs9292125 chr5:56107200 C/T cg24531977 chr5:56204891 C5orf35 -0.82 -11.09 -0.52 1.7e-24 Initial pursuit acceleration; CRC trans rs9825823 0.617 rs2083264 chr3:61074229 A/G cg22062239 chr16:31106011 VKORC1 0.44 6.11 0.32 2.74e-9 Depressive symptom measurement or major depressive disorder; CRC cis rs3796352 1.000 rs71301808 chr3:53085577 C/G cg06204229 chr3:52865917 ITIH4 0.5 5.86 0.31 1.11e-8 Immune reponse to smallpox (secreted IL-2); CRC cis rs10504229 0.683 rs56204590 chr8:58131642 T/G cg21724239 chr8:58056113 NA 0.49 6.81 0.35 4.75e-11 Developmental language disorder (linguistic errors); CRC cis rs12497850 0.931 rs4072859 chr3:49032205 G/C cg07636037 chr3:49044803 WDR6 1.03 18.28 0.71 4.94e-52 Parkinson's disease; CRC trans rs1455244 0.700 rs7229302 chr18:11508904 G/T cg24620338 chr11:71498715 FAM86C 0.42 6.56 0.34 2.06e-10 Schizophrenia; CRC cis rs10946940 0.965 rs6915266 chr6:27528643 G/A cg08798685 chr6:27730294 NA 0.4 6.07 0.32 3.51e-9 Systemic lupus erythematosus; CRC cis rs77633900 0.772 rs2078437 chr15:76669580 A/G cg21673338 chr15:77095150 SCAPER 0.68 6.31 0.33 9.13e-10 Non-glioblastoma glioma;Glioma; CRC cis rs4713118 0.513 rs149878 chr6:27878738 T/G cg10876282 chr6:28092338 ZSCAN16 0.43 5.74 0.3 2.16e-8 Parkinson's disease; CRC cis rs921968 0.643 rs532475 chr2:219434208 C/T cg02176678 chr2:219576539 TTLL4 0.48 7.99 0.4 2.35e-14 Mean corpuscular hemoglobin concentration; CRC cis rs7827545 1.000 rs2119879 chr8:135549042 T/C cg17885191 chr8:135476712 NA 0.6 8.38 0.42 1.51e-15 Hypertension (SNP x SNP interaction); CRC cis rs908922 0.627 rs1053588 chr1:152488063 C/T cg09873164 chr1:152488093 CRCT1 0.36 6.05 0.32 3.84e-9 Hair morphology; CRC cis rs9486715 1.000 rs7752277 chr6:97065131 C/T cg18709589 chr6:96969512 KIAA0776 -0.46 -6.63 -0.34 1.39e-10 Headache; CRC cis rs1218582 0.772 rs11264290 chr1:154912300 C/T cg03351412 chr1:154909251 PMVK 0.53 8.43 0.42 1.07e-15 Prostate cancer; CRC trans rs16953946 0.542 rs8048249 chr16:80743431 C/G cg11504718 chr13:113537807 ATP11A -0.57 -6.01 -0.31 4.94e-9 Inflammatory bowel disease; CRC cis rs10504229 1.000 rs67039591 chr8:58174553 T/A cg05313129 chr8:58192883 C8orf71 -0.47 -6.99 -0.36 1.49e-11 Developmental language disorder (linguistic errors); CRC cis rs2404602 0.583 rs12913096 chr15:76551852 C/T cg26408565 chr15:76604113 ETFA -0.36 -5.62 -0.3 4.08e-8 Blood metabolite levels; CRC cis rs7591163 1.000 rs7591163 chr2:228715375 C/T cg14646075 chr2:228736089 WDR69 -0.46 -6.2 -0.32 1.72e-9 Blood pressure; CRC cis rs2635047 1.000 rs2684841 chr18:44724262 C/T cg19077165 chr18:44547161 KATNAL2 -0.47 -7.61 -0.39 2.91e-13 Educational attainment; CRC cis rs11997175 0.624 rs7819074 chr8:33682472 C/T cg04338863 chr8:33670619 NA 0.44 6.99 0.36 1.52e-11 Body mass index; CRC cis rs7591163 1.000 rs6738964 chr2:228739135 G/T cg23807890 chr2:228736357 WDR69 -0.5 -6.91 -0.36 2.53e-11 Blood pressure; CRC cis rs2075371 0.965 rs2544216 chr7:133987902 G/A cg11752832 chr7:134001865 SLC35B4 0.5 7.71 0.39 1.55e-13 Mean platelet volume; CRC cis rs3736485 0.903 rs9944241 chr15:51898058 T/C cg08986416 chr15:51914746 DMXL2 -0.45 -6.46 -0.34 3.73e-10 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs11212617 1.000 rs645485 chr11:108168863 A/G cg12106634 chr11:108092400 ATM;NPAT 0.42 6.12 0.32 2.73e-9 Response to metformin in type 2 diabetes (glycemic); CRC cis rs853679 0.517 rs12332979 chr6:28141548 T/G cg02631126 chr6:28058918 ZSCAN12L1 0.29 5.73 0.3 2.26e-8 Depression; CRC cis rs6758955 0.850 rs6755410 chr2:10480083 A/C cg15773312 chr2:10472214 HPCAL1 -0.83 -9.55 -0.47 3.01e-19 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; CRC cis rs775227 0.574 rs66866534 chr3:113147315 T/C cg18753928 chr3:113234510 CCDC52 -0.58 -6.98 -0.36 1.66e-11 Dental caries; CRC cis rs6964587 1.000 rs10234071 chr7:91645152 C/G cg17063962 chr7:91808500 NA -0.79 -14.31 -0.62 1.89e-36 Breast cancer; CRC cis rs6502050 0.799 rs28376857 chr17:80104351 G/A cg11859384 chr17:80120422 CCDC57 -0.37 -5.85 -0.31 1.16e-8 Life satisfaction; CRC cis rs11098499 0.955 rs56386062 chr4:120155135 T/C cg09307838 chr4:120376055 NA 0.63 9.72 0.47 8.33e-20 Corneal astigmatism; CRC cis rs6964587 0.934 rs4512319 chr7:91733829 G/A cg01689657 chr7:91764605 CYP51A1 0.34 5.6 0.3 4.43e-8 Breast cancer; CRC cis rs7677751 0.806 rs7681399 chr4:55090886 T/G cg17187183 chr4:55093834 PDGFRA 0.53 7.62 0.39 2.8e-13 Corneal astigmatism; CRC cis rs12824058 0.831 rs12297939 chr12:130811923 G/C cg24838063 chr12:130822603 PIWIL1 0.58 9.76 0.47 6.18e-20 Menopause (age at onset); CRC cis rs612683 0.658 rs12407689 chr1:100999585 C/G cg06223162 chr1:101003688 GPR88 0.39 7.1 0.36 7.71e-12 Breast cancer; CRC cis rs8014204 0.604 rs11159109 chr14:75389074 G/A cg03030879 chr14:75389066 RPS6KL1 -0.7 -11.69 -0.54 1.25e-26 Caffeine consumption; CRC cis rs6546550 0.867 rs6738174 chr2:70150215 A/C cg02498382 chr2:70120550 SNRNP27 -0.56 -9.52 -0.46 3.78e-19 Prevalent atrial fibrillation; CRC cis rs1552244 1.000 rs6791810 chr3:10124444 A/G cg13047869 chr3:10149882 C3orf24 -0.56 -7.75 -0.39 1.18e-13 Alzheimer's disease; CRC cis rs875971 0.543 rs801191 chr7:66032955 G/A cg18876405 chr7:65276391 NA -0.58 -10.39 -0.5 4.61e-22 Aortic root size; CRC cis rs2404602 0.735 rs3765115 chr15:76673716 T/C cg23625390 chr15:77176239 SCAPER -0.82 -13.24 -0.59 2.19e-32 Blood metabolite levels; CRC cis rs3772130 0.603 rs10470410 chr3:121434977 G/T cg20356878 chr3:121714668 ILDR1 0.56 10.13 0.49 3.62e-21 Cognitive performance; CRC cis rs34779708 0.931 rs4934524 chr10:35270921 G/C cg03585969 chr10:35415529 CREM 0.66 8.76 0.43 1.09e-16 Inflammatory bowel disease;Crohn's disease; CRC cis rs1448094 0.933 rs11117102 chr12:86312720 A/C cg02569458 chr12:86230093 RASSF9 0.38 6.51 0.34 2.85e-10 Major depressive disorder; CRC cis rs2806561 0.765 rs1738470 chr1:23511911 G/A cg12483005 chr1:23474871 LUZP1 0.5 7.37 0.38 1.36e-12 Height; CRC trans rs6540559 0.546 rs59435160 chr1:210030730 C/A cg24434056 chr13:112550360 NA 0.36 6.01 0.31 4.89e-9 Cleft lip with or without cleft palate; CRC cis rs2535633 0.631 rs2465101 chr3:52991307 A/T cg15147215 chr3:52552868 STAB1 0.42 6.74 0.35 7.13e-11 Body mass index; CRC cis rs6582630 0.538 rs7971292 chr12:38498151 A/G cg13010199 chr12:38710504 ALG10B -0.43 -6.25 -0.33 1.3e-9 Drug-induced liver injury (flucloxacillin); CRC cis rs67311347 1.000 rs6599102 chr3:40468406 G/A cg24209194 chr3:40518798 ZNF619 0.43 6.46 0.34 3.79e-10 Renal cell carcinoma; CRC cis rs7178572 1.000 rs62007299 chr15:77711719 G/A cg22256960 chr15:77711686 NA -0.69 -10.65 -0.51 5.92e-23 Type 2 diabetes; CRC cis rs8060686 0.641 rs2418737 chr16:68122726 T/C cg26727032 chr16:67993705 SLC12A4 -0.59 -7.44 -0.38 8.71e-13 HDL cholesterol;Metabolic syndrome; CRC trans rs941408 0.515 rs1005556 chr19:2778543 G/T cg22153745 chr1:153894579 GATAD2B -0.53 -7.44 -0.38 8.6e-13 Total cholesterol levels; CRC cis rs7512552 1.000 rs7512552 chr1:150265704 T/C cg15654264 chr1:150340011 RPRD2 -0.54 -7.97 -0.4 2.7e-14 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); CRC cis rs7589728 0.563 rs78685993 chr2:88447026 T/C cg14558114 chr2:88469736 THNSL2 0.62 6.22 0.32 1.48e-9 Plasma clusterin levels; CRC cis rs7618915 0.524 rs35249778 chr3:52661640 G/C cg08222913 chr3:52553049 STAB1 -0.34 -6.13 -0.32 2.58e-9 Bipolar disorder; CRC cis rs2549003 0.966 rs10072571 chr5:131816711 A/C cg00255919 chr5:131827918 IRF1 0.59 11.88 0.55 2.57e-27 Asthma (sex interaction); CRC cis rs9420 0.961 rs7116341 chr11:57481155 G/A cg23127183 chr11:57508653 C11orf31 -0.52 -7.07 -0.36 9.19e-12 Schizophrenia; CRC cis rs6502050 0.835 rs7406529 chr17:80080877 C/T cg09264619 chr17:80180166 NA 0.38 6.44 0.33 4.28e-10 Life satisfaction; CRC cis rs25422 0.878 rs55894300 chr6:118982076 T/A cg24463073 chr6:118973353 C6orf204 0.5 6.21 0.32 1.63e-9 Renal cell carcinoma; CRC trans rs6076960 0.598 rs3905168 chr20:6226752 C/T cg17788362 chr6:86352627 SYNCRIP 0.5 6.88 0.35 3e-11 Smooth-surface caries; CRC cis rs17711722 1.000 rs17711722 chr7:65271197 C/T cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.48 -7.1 -0.36 7.87e-12 Calcium levels; CRC cis rs6502050 0.799 rs9675196 chr17:80096655 C/T cg22110888 chr17:80059540 CCDC57 0.41 6.49 0.34 3.15e-10 Life satisfaction; CRC cis rs10504229 0.728 rs17804365 chr8:58151537 C/A cg11062466 chr8:58055876 NA 0.45 6.11 0.32 2.74e-9 Developmental language disorder (linguistic errors); CRC cis rs8070740 0.786 rs34856659 chr17:5327572 T/C cg25236894 chr17:5323110 RPAIN;NUP88 0.47 6.86 0.35 3.46e-11 Menopause (age at onset); CRC cis rs1691799 0.867 rs1027400 chr12:66760922 A/T cg16791601 chr12:66731901 HELB -0.73 -12.62 -0.57 4.77e-30 White blood cell count (basophil); CRC cis rs7605827 0.930 rs6733647 chr2:15542159 A/G cg19274914 chr2:15703543 NA 0.4 5.94 0.31 7.2e-9 Educational attainment (years of education); CRC cis rs7264396 0.832 rs224349 chr20:34045392 G/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.42 -6.85 -0.35 3.64e-11 Total cholesterol levels; CRC cis rs7666738 0.830 rs34313689 chr4:99013689 T/C cg17366294 chr4:99064904 C4orf37 0.43 7.16 0.37 5.16e-12 Colonoscopy-negative controls vs population controls; CRC cis rs3733346 0.520 rs62297086 chr4:909040 G/A cg15105011 chr4:940614 TMEM175 0.55 9.15 0.45 5.95e-18 Sjögren's syndrome; CRC cis rs9814567 1.000 rs13087875 chr3:134261123 C/T cg06541857 chr3:134203789 ANAPC13;CEP63 0.39 5.74 0.3 2.15e-8 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs9325144 0.560 rs2013804 chr12:38631079 C/T cg26384229 chr12:38710491 ALG10B -0.49 -7.2 -0.37 4.11e-12 Morning vs. evening chronotype; CRC cis rs6679356 0.789 rs6672670 chr1:67818577 C/T cg24364144 chr1:67875067 SERBP1 0.43 6.66 0.34 1.14e-10 Primary biliary cholangitis; CRC cis rs13108904 0.935 rs4974575 chr4:1252028 A/G cg16405210 chr4:1374714 KIAA1530 -0.48 -6.89 -0.35 2.9e-11 Obesity-related traits; CRC cis rs2075165 0.901 rs10908492 chr1:156224795 C/T cg20302342 chr1:156215951 PAQR6 0.4 7.85 0.4 5.83e-14 Tonsillectomy; CRC trans rs2303319 0.504 rs55925603 chr2:162497210 G/A cg22988483 chr14:93581567 ITPK1 -0.66 -6.08 -0.32 3.27e-9 Cognitive function; CRC cis rs17095355 1.000 rs734163 chr10:111698192 A/G cg00817464 chr10:111662876 XPNPEP1 -0.53 -7.27 -0.37 2.68e-12 Biliary atresia; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg20376447 chr17:60143446 MED13 0.46 6.82 0.35 4.29e-11 Intelligence (multi-trait analysis); CRC cis rs6952808 1.000 rs6954673 chr7:1886937 C/T cg00106254 chr7:1943704 MAD1L1 -0.44 -6.26 -0.33 1.22e-9 Bipolar disorder and schizophrenia; CRC cis rs919433 0.963 rs10153881 chr2:198171098 T/C cg20885578 chr2:198174922 NA -0.42 -6.82 -0.35 4.34e-11 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC cis rs965469 0.779 rs6133034 chr20:3337661 A/G cg25506879 chr20:3388711 C20orf194 -0.37 -5.69 -0.3 2.86e-8 IFN-related cytopenia; CRC cis rs1023500 0.551 rs133371 chr22:42465574 G/A cg11915388 chr22:42470451 FAM109B -0.42 -6.47 -0.34 3.63e-10 Schizophrenia; CRC cis rs6502050 0.731 rs35156322 chr17:80096323 T/C cg13198984 chr17:80129470 CCDC57 0.46 8.16 0.41 6.94e-15 Life satisfaction; CRC cis rs4588572 0.644 rs6882191 chr5:77743098 G/A cg11547950 chr5:77652471 NA -0.48 -7.03 -0.36 1.19e-11 Triglycerides; CRC cis rs4253772 0.637 rs36125344 chr22:46655779 G/C cg24881330 chr22:46731750 TRMU 0.57 5.65 0.3 3.46e-8 LDL cholesterol;Cholesterol, total; CRC cis rs12142240 0.698 rs966907 chr1:46817125 C/G cg00530320 chr1:46809349 NSUN4 0.57 7.75 0.39 1.19e-13 Menopause (age at onset); CRC cis rs904251 0.828 rs1757174 chr6:37486695 G/A cg01843034 chr6:37503916 NA -0.48 -8.8 -0.44 7.73e-17 Cognitive performance; CRC cis rs1005277 0.579 rs2474580 chr10:38398713 G/A cg25517755 chr10:38738941 LOC399744 -0.44 -6.44 -0.33 4.23e-10 Extrinsic epigenetic age acceleration; CRC cis rs9443645 0.869 rs4706747 chr6:79722639 A/G cg05283184 chr6:79620031 NA -0.61 -9.64 -0.47 1.54e-19 Intelligence (multi-trait analysis); CRC cis rs6921919 0.609 rs9468357 chr6:28342053 T/C cg21251018 chr6:28226885 NKAPL 0.4 6.09 0.32 3.12e-9 Autism spectrum disorder or schizophrenia; CRC cis rs853679 0.760 rs9468317 chr6:28198456 A/G cg12172441 chr6:28176163 NA 0.53 5.77 0.3 1.85e-8 Depression; CRC cis rs684232 0.602 rs384628 chr17:554912 G/A cg15660573 chr17:549704 VPS53 -0.86 -15.77 -0.66 3.96e-42 Prostate cancer; CRC cis rs9648428 0.515 rs4723485 chr7:36205242 G/T cg14708893 chr7:36124863 NA -0.44 -6.34 -0.33 7.43e-10 Obesity-related traits; CRC cis rs514406 0.621 rs928452 chr1:53195926 G/C cg27535305 chr1:53392650 SCP2 0.36 6.42 0.33 4.77e-10 Monocyte count; CRC cis rs6088580 0.634 rs6142164 chr20:33006597 C/T cg24642439 chr20:33292090 TP53INP2 -0.38 -6.41 -0.33 5.19e-10 Glomerular filtration rate (creatinine); CRC cis rs7089973 0.966 rs55711292 chr10:116604870 T/G cg23260525 chr10:116636907 FAM160B1 0.32 6.4 0.33 5.32e-10 Bipolar disorder or attention deficit hyperactivity disorder; CRC trans rs561341 1.000 rs550264 chr17:30317540 G/T cg20587970 chr11:113659929 NA -1.43 -20.38 -0.75 2.82e-60 Hip circumference adjusted for BMI; CRC cis rs801193 0.636 rs10233806 chr7:66118248 G/C cg18912574 chr7:65842487 NCRNA00174 -0.36 -5.97 -0.31 6.21e-9 Aortic root size; CRC cis rs875971 0.660 rs6460308 chr7:66084740 T/C cg00343986 chr7:65444356 GUSB -0.51 -7.62 -0.39 2.71e-13 Aortic root size; CRC cis rs875971 0.862 rs801195 chr7:66026115 A/G cg12463550 chr7:65579703 CRCP -0.47 -6.4 -0.33 5.38e-10 Aortic root size; CRC cis rs4713118 0.586 rs9468290 chr6:28087674 C/T cg12963246 chr6:28129442 ZNF389 0.5 5.8 0.3 1.53e-8 Parkinson's disease; CRC cis rs60871478 0.685 rs34421533 chr7:816638 A/G cg13798912 chr7:905769 UNC84A 0.59 6.43 0.33 4.59e-10 Cerebrospinal P-tau181p levels; CRC cis rs2073499 0.872 rs58051625 chr3:50278717 G/C cg09545109 chr3:50388910 TUSC4;CYB561D2 0.61 5.71 0.3 2.52e-8 Schizophrenia; CRC cis rs6952808 1.000 rs12540579 chr7:1882227 C/A cg05279229 chr7:1896384 MAD1L1 -0.36 -5.7 -0.3 2.64e-8 Bipolar disorder and schizophrenia; CRC cis rs72615157 0.612 rs7786505 chr7:99817585 G/T cg13153964 chr7:100026424 MEPCE;ZCWPW1 0.79 9.82 0.48 4.06e-20 Lung function (FEV1/FVC); CRC cis rs5753037 0.676 rs6006267 chr22:30216982 C/A cg01021169 chr22:30184971 ASCC2 -0.43 -6.67 -0.35 1.07e-10 Type 1 diabetes; CRC cis rs523522 0.962 rs9788155 chr12:120938408 G/A cg27279351 chr12:120934652 DYNLL1 0.79 11.6 0.54 2.58e-26 High light scatter reticulocyte count; CRC cis rs9399135 0.967 rs1590975 chr6:135352088 C/T cg24558204 chr6:135376177 HBS1L 0.51 8.03 0.4 1.8e-14 Red blood cell count; CRC cis rs9303280 0.776 rs11078926 chr17:38062976 G/A cg17344932 chr17:38183730 MED24;SNORD124 0.39 6.21 0.32 1.62e-9 Self-reported allergy; CRC cis rs9534288 0.659 rs1581846 chr13:46650686 G/A cg15192986 chr13:46630673 CPB2 -0.62 -8.49 -0.42 7.19e-16 Blood protein levels; CRC cis rs1223397 0.651 rs2439542 chr6:13311823 G/A cg07912922 chr6:13274314 PHACTR1 0.38 6.0 0.31 5.21e-9 Blood pressure; CRC cis rs4132509 0.948 rs7517921 chr1:243856420 T/C cg21452805 chr1:244014465 NA 0.5 6.68 0.35 1.01e-10 RR interval (heart rate); CRC cis rs2370759 1.000 rs7910776 chr10:32639093 C/T cg01819863 chr10:32635814 EPC1 1.11 12.18 0.56 1.97e-28 Sexual dysfunction (female); CRC trans rs944990 0.595 rs10123378 chr9:96375217 C/T cg26422674 chr12:10766150 MAGOHB 0.38 5.99 0.31 5.37e-9 Body mass index; CRC cis rs6938 0.596 rs11072511 chr15:75159433 A/G cg17294928 chr15:75287854 SCAMP5 0.5 7.74 0.39 1.27e-13 Breast cancer; CRC cis rs6540556 0.769 rs6540553 chr1:209929044 C/G cg23920097 chr1:209922102 NA -0.55 -6.73 -0.35 7.61e-11 Red blood cell count; CRC cis rs853679 0.517 rs16893666 chr6:28054707 C/T cg25164649 chr6:28176230 NA -0.74 -9.4 -0.46 9.82e-19 Depression; CRC cis rs6582630 0.537 rs11611326 chr12:38547958 C/A cg13010199 chr12:38710504 ALG10B 0.47 6.0 0.31 5.3300000000000004e-09 Drug-induced liver injury (flucloxacillin); CRC cis rs1707322 1.000 rs6682683 chr1:46342337 A/G cg06784218 chr1:46089804 CCDC17 0.51 8.95 0.44 2.75e-17 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs73186030 0.920 rs2001548 chr3:122032789 C/T cg16331599 chr3:121796627 CD86 0.51 5.8 0.3 1.52e-8 Serum parathyroid hormone levels; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg26942392 chr20:5591638 RP5-1022P6.2 0.48 7.73 0.39 1.32e-13 Liver disease severity in Alagille syndrome; CRC trans rs1005277 0.579 rs2021649 chr10:38392122 C/T cg23533926 chr12:111358616 MYL2 -0.53 -7.89 -0.4 4.39e-14 Extrinsic epigenetic age acceleration; CRC trans rs7618501 1.000 rs7634902 chr3:49762662 G/T cg21582582 chr3:182698605 DCUN1D1 -0.56 -8.24 -0.41 4.05e-15 Intelligence (multi-trait analysis); CRC cis rs1065852 0.526 rs59993856 chr22:42403980 C/T cg00645731 chr22:42541494 CYP2D7P1 0.4 6.89 0.36 2.84e-11 Response to serotonin reuptake inhibitors in major depressive disorder (plasma drug and metabolite levels); CRC trans rs4650994 0.544 rs4652301 chr1:178499799 T/C cg05059571 chr16:84539110 KIAA1609 -0.64 -8.61 -0.43 3.08e-16 HDL cholesterol levels;HDL cholesterol; CRC cis rs8072100 0.870 rs10432035 chr17:45624913 G/C cg08085267 chr17:45401833 C17orf57 0.62 10.03 0.48 7.74e-21 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs7843479 0.582 rs7009693 chr8:21775314 C/T cg16476235 chr8:21771668 DOK2 0.35 6.02 0.31 4.66e-9 Mean corpuscular volume; CRC cis rs59918340 0.616 rs3739222 chr8:142205904 C/G cg18755752 chr8:142205143 DENND3 -0.52 -8.26 -0.41 3.7e-15 Immature fraction of reticulocytes; CRC cis rs4594175 0.926 rs11157800 chr14:51615502 A/T cg23942311 chr14:51606299 NA 0.66 11.17 0.52 8.96e-25 Cancer; CRC trans rs2303319 0.504 rs62188988 chr2:162531068 T/C cg23919916 chr10:103825097 HPS6 -0.69 -6.06 -0.32 3.73e-9 Cognitive function; CRC cis rs9911578 0.817 rs304264 chr17:56749628 A/G cg05425664 chr17:57184151 TRIM37 -0.48 -7.64 -0.39 2.44e-13 Intelligence (multi-trait analysis); CRC cis rs8062405 0.964 rs62036614 chr16:28824685 T/C cg16576597 chr16:28551801 NUPR1 0.43 5.85 0.31 1.18e-8 Cognitive ability (multi-trait analysis);Cognitive ability; CRC cis rs4363385 0.747 rs1413848 chr1:152970210 C/T cg25856811 chr1:152973957 SPRR3 -0.25 -6.92 -0.36 2.36e-11 Inflammatory skin disease; CRC cis rs11122272 0.735 rs2749706 chr1:231527170 C/A cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.55 -8.18 -0.41 6.23e-15 Hemoglobin concentration; CRC cis rs7552404 0.727 rs5745427 chr1:76332637 C/A cg03433033 chr1:76189801 ACADM -0.64 -8.52 -0.42 6e-16 Blood metabolite levels;Acylcarnitine levels; CRC cis rs11148252 0.514 rs3818422 chr13:52719214 C/T cg00495681 chr13:53174319 NA -0.54 -7.9 -0.4 4.3e-14 Lewy body disease; CRC cis rs769267 0.930 rs747050 chr19:19584987 C/G cg02546618 chr19:19431379 KIAA0892;SF4 0.45 6.19 0.32 1.78e-9 Tonsillectomy; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg05529848 chr2:25600059 NA 0.45 6.37 0.33 6.39e-10 Response to antipsychotic treatment; CRC cis rs9649465 0.967 rs6966470 chr7:123299855 C/T cg03229431 chr7:123269106 ASB15 0.38 5.86 0.31 1.14e-8 Migraine; CRC cis rs6743376 0.556 rs2441376 chr2:113817755 T/C cg24553058 chr2:113831203 IL1F10 0.42 6.9 0.36 2.69e-11 Inflammatory biomarkers; CRC cis rs796364 0.951 rs7608668 chr2:201000017 T/C cg25936922 chr2:200820526 C2orf60;C2orf47 -0.65 -7.25 -0.37 3.08e-12 Schizophrenia; CRC cis rs4728302 0.869 rs10231102 chr7:133573310 G/A cg10665199 chr7:133106180 EXOC4 0.43 6.52 0.34 2.68e-10 Intelligence;Intelligence (multi-trait analysis); CRC cis rs1865760 0.820 rs9348697 chr6:25890834 C/T cg16482183 chr6:26056742 HIST1H1C 0.56 8.42 0.42 1.21e-15 Height; CRC cis rs9488822 0.676 rs873879 chr6:116391259 A/G cg18764771 chr6:116381957 FRK 0.26 7.42 0.38 1.03e-12 Cholesterol, total;LDL cholesterol; CRC trans rs17685 0.753 rs12531559 chr7:75631697 C/T cg19862616 chr7:65841803 NCRNA00174 -0.97 -18.55 -0.71 4.42e-53 Coffee consumption;Coffee consumption (cups per day); CRC trans rs9545047 0.680 rs9574405 chr13:79903078 A/G cg07061582 chr15:90234082 PEX11A;WDR93 0.41 5.97 0.31 6.22e-9 Schizophrenia; CRC cis rs1355223 0.583 rs2915177 chr11:34880266 A/G cg11058730 chr11:34937778 PDHX;APIP 0.71 11.58 0.54 3.06e-26 Systemic lupus erythematosus and Systemic sclerosis; CRC cis rs7959452 0.535 rs1350166 chr12:69636314 G/T cg22834771 chr12:69754056 YEATS4 -0.42 -5.94 -0.31 7.35e-9 Blood protein levels; CRC cis rs9322193 0.886 rs9767555 chr6:149968158 T/C cg13206674 chr6:150067644 NUP43 0.67 9.39 0.46 1.02e-18 Lung cancer; CRC cis rs7223966 0.883 rs2727317 chr17:61961302 C/T cg23090583 chr17:61904693 PSMC5;FTSJ3 0.46 5.74 0.3 2.17e-8 Hip circumference adjusted for BMI;Body mass index; CRC cis rs1799949 0.965 rs4793230 chr17:41427403 A/C cg19454999 chr17:41278357 BRCA1;NBR2 0.4 6.18 0.32 1.84e-9 Menopause (age at onset); CRC cis rs992157 0.717 rs11692780 chr2:219149163 A/G cg04880052 chr2:219191631 PNKD -0.43 -6.8 -0.35 4.8e-11 Colorectal cancer; CRC cis rs17253792 0.822 rs80328469 chr14:56067701 G/A cg24579896 chr14:56047964 C14orf33;KTN1 0.71 5.69 0.3 2.81e-8 Putamen volume; CRC trans rs6703335 0.870 rs10803142 chr1:243598234 A/G cg24538372 chr2:105953882 C2orf49 0.47 6.54 0.34 2.33e-10 Schizophrenia;Schizophrenia, schizoaffective disorder or bipolar disorder; CRC cis rs9311474 0.597 rs6778735 chr3:52565100 T/C cg18591801 chr3:52553433 STAB1 -0.35 -6.97 -0.36 1.78e-11 Electroencephalogram traits; CRC cis rs853679 0.517 rs9366715 chr6:28064633 A/G cg02631126 chr6:28058918 ZSCAN12L1 0.3 6.11 0.32 2.83e-9 Depression; CRC cis rs6938 0.534 rs7495739 chr15:75185670 C/T cg14664628 chr15:75095509 CSK 0.67 10.51 0.5 1.88e-22 Breast cancer; CRC cis rs12995491 0.731 rs56188884 chr2:88508657 G/A cg07952391 chr2:88470173 THNSL2 -0.42 -6.2 -0.32 1.71e-9 Response to metformin (IC50); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg08578305 chr12:25403937 KRAS 0.39 6.02 0.31 4.63e-9 Liver disease severity in Alagille syndrome; CRC cis rs3858526 0.676 rs10838772 chr11:5895754 T/C cg13902645 chr11:5959945 NA -0.57 -7.28 -0.37 2.5e-12 DNA methylation (variation); CRC cis rs4148883 0.689 rs2851275 chr4:100024883 A/G cg13256891 chr4:100009986 ADH5 0.45 6.41 0.33 5.03e-10 Alcohol dependence; CRC cis rs9322193 0.923 rs9377230 chr6:149934743 T/C cg07701084 chr6:150067640 NUP43 0.54 7.93 0.4 3.47e-14 Lung cancer; CRC cis rs1129187 0.967 rs3805952 chr6:42937126 C/T cg26304593 chr6:42947056 PEX6 -0.41 -5.75 -0.3 2.05e-8 Alzheimer's disease in APOE e4+ carriers; CRC cis rs28386778 0.897 rs2665797 chr17:61922485 C/G cg06873352 chr17:61820015 STRADA -0.75 -14.16 -0.62 7.07e-36 Prudent dietary pattern; CRC cis rs6968419 0.674 rs12669768 chr7:115907140 C/T cg02561103 chr7:115862891 TES -0.42 -6.2 -0.32 1.66e-9 Intraocular pressure; CRC cis rs13108904 0.934 rs13125842 chr4:1280947 G/A cg02018176 chr4:1364513 KIAA1530 0.48 7.9 0.4 4.1e-14 Obesity-related traits; CRC cis rs1552244 0.882 rs3732967 chr3:10015437 T/C cg08888203 chr3:10149979 C3orf24 0.62 8.23 0.41 4.29e-15 Alzheimer's disease; CRC cis rs6674176 0.660 rs2108202 chr1:44395786 A/G cg13606994 chr1:44402422 ARTN 0.38 6.42 0.33 4.82e-10 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Cognitive ability; CRC cis rs4149423 1.000 rs12620050 chr2:108919798 G/A cg25838818 chr2:108905173 SULT1C2 -0.51 -7.8 -0.4 8.16e-14 Lobe size; CRC trans rs2303319 0.504 rs62189051 chr2:162622318 G/A cg22677401 chr17:46026860 NA -0.67 -6.09 -0.32 3.14e-9 Cognitive function; CRC trans rs2303319 0.504 rs62188988 chr2:162531068 T/C cg05865860 chr7:158649142 WDR60 -0.7 -5.97 -0.31 6.26e-9 Cognitive function; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg22455090 chr5:89825803 LYSMD3 0.43 6.14 0.32 2.39e-9 Intelligence (multi-trait analysis); CRC cis rs798554 0.757 rs2533878 chr7:2878707 A/G cg04166393 chr7:2884313 GNA12 -0.53 -7.14 -0.37 6.07e-12 Height; CRC cis rs12024301 0.557 rs10911399 chr1:183646903 A/G cg11505048 chr1:183622726 RGL1;APOBEC4 0.69 5.88 0.31 9.99e-9 Peripheral arterial disease (traffic-related air pollution interaction); CRC trans rs208520 0.874 rs208514 chr6:66945520 G/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.91 -11.86 -0.55 2.97e-27 Exhaled nitric oxide output; CRC cis rs11792861 0.851 rs4542004 chr9:111814478 A/G cg05043794 chr9:111880884 C9orf5 -0.33 -6.14 -0.32 2.35e-9 Menarche (age at onset); CRC cis rs739496 0.542 rs7306529 chr12:111780644 A/G cg10833066 chr12:111807467 FAM109A 0.55 6.92 0.36 2.4e-11 Platelet count; CRC cis rs7786808 0.564 rs10267128 chr7:158198490 G/A cg15440763 chr7:158190612 PTPRN2 -0.38 -6.17 -0.32 1.96e-9 Obesity-related traits; CRC trans rs4824093 0.610 rs9627799 chr22:50317989 C/T cg09872104 chr7:134855509 C7orf49 -0.79 -7.27 -0.37 2.67e-12 Amyotrophic lateral sclerosis (sporadic); CRC cis rs2836974 0.897 rs34394827 chr21:40528087 T/C cg11644478 chr21:40555479 PSMG1 0.8 12.55 0.57 8.94e-30 Cognitive function; CRC cis rs6963495 0.719 rs73190174 chr7:105161216 T/G cg13798780 chr7:105162888 PUS7 0.68 8.08 0.41 1.27e-14 Bipolar disorder (body mass index interaction); CRC cis rs17152411 0.895 rs11245420 chr10:126586469 T/C cg07906193 chr10:126599966 NA 0.56 6.33 0.33 7.97e-10 Height; CRC cis rs7527798 0.592 rs10863437 chr1:207817612 T/C cg09232269 chr1:207846808 CR1L -0.5 -7.96 -0.4 2.73e-14 Erythrocyte sedimentation rate; CRC cis rs12142240 0.698 rs12385696 chr1:46818836 A/G cg00530320 chr1:46809349 NSUN4 0.58 7.87 0.4 5.16e-14 Menopause (age at onset); CRC cis rs10883723 0.810 rs2281879 chr10:104268877 C/G cg22532475 chr10:104410764 TRIM8 -0.38 -6.95 -0.36 1.95e-11 Allergic disease (asthma, hay fever or eczema); CRC cis rs13108904 0.967 rs900029 chr4:1279145 C/T cg02018176 chr4:1364513 KIAA1530 0.48 7.96 0.4 2.74e-14 Obesity-related traits; CRC cis rs4969178 0.965 rs12450500 chr17:76395750 C/T cg20026190 chr17:76395443 PGS1 0.4 6.2 0.32 1.73e-9 HDL cholesterol levels; CRC cis rs9399135 0.684 rs1135205 chr6:135281795 C/T cg24558204 chr6:135376177 HBS1L 0.52 7.93 0.4 3.4e-14 Red blood cell count; CRC cis rs9926296 0.533 rs10852623 chr16:89865242 T/C cg03388025 chr16:89894329 SPIRE2 0.45 9.23 0.45 3.29e-18 Vitiligo; CRC trans rs2235573 0.657 rs4821731 chr22:38445214 C/A cg19894588 chr14:64061835 NA 0.43 6.31 0.33 8.9e-10 Glioblastoma;Glioma; CRC cis rs9359856 0.564 rs17228548 chr6:90439164 T/C cg13799429 chr6:90582589 CASP8AP2 -0.75 -7.61 -0.39 2.88e-13 Bipolar disorder; CRC cis rs9916302 0.904 rs10432031 chr17:37397852 G/A cg07936489 chr17:37558343 FBXL20 -0.79 -11.87 -0.55 2.73e-27 Glomerular filtration rate (creatinine); CRC cis rs2559856 0.935 rs2695287 chr12:102088361 T/C cg12924262 chr12:102091054 CHPT1 0.55 8.26 0.41 3.59e-15 Blood protein levels; CRC trans rs2303319 0.504 rs1006427 chr2:162592328 T/C cg23247704 chr1:116518985 SLC22A15 -0.72 -6.14 -0.32 2.42e-9 Cognitive function; CRC cis rs826838 0.935 rs1684407 chr12:39127270 C/T cg26384229 chr12:38710491 ALG10B -0.64 -9.58 -0.47 2.56e-19 Heart rate; CRC cis rs6860806 0.507 rs273901 chr5:131694360 G/T cg02033258 chr5:131593261 PDLIM4 0.37 6.27 0.33 1.14e-9 Breast cancer; CRC cis rs9611565 0.729 rs132902 chr22:41797758 A/G cg03806693 chr22:41940476 POLR3H -0.95 -12.36 -0.56 4.36e-29 Vitiligo; CRC cis rs1005277 0.522 rs289650 chr10:37975505 G/T cg00409905 chr10:38381863 ZNF37A -0.64 -10.92 -0.52 6.54e-24 Extrinsic epigenetic age acceleration; CRC trans rs11098499 0.604 rs10022185 chr4:120571765 C/G cg25214090 chr10:38739885 LOC399744 0.56 8.35 0.42 1.95e-15 Corneal astigmatism; CRC cis rs727479 0.502 rs12148604 chr15:51501404 A/G cg19946085 chr15:51559439 CYP19A1 0.28 5.89 0.31 9.3e-9 Estradiol levels; CRC cis rs2153535 0.580 rs6927589 chr6:8456632 A/G cg07606381 chr6:8435919 SLC35B3 -0.67 -10.99 -0.52 4e-24 Motion sickness; CRC cis rs2404602 0.684 rs2047504 chr15:76883516 A/T cg03037974 chr15:76606532 NA -0.52 -7.66 -0.39 2.14e-13 Blood metabolite levels; CRC cis rs7113874 0.569 rs10769916 chr11:8598214 G/A cg17679104 chr11:8615758 STK33 -0.36 -6.02 -0.31 4.73e-9 Body mass index in physically active individuals;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs739401 0.611 rs2071104 chr11:3036933 G/T cg08508325 chr11:3079039 CARS -0.51 -9.63 -0.47 1.72e-19 Longevity; CRC cis rs1881797 1.000 rs10158379 chr1:247686352 C/A cg21399703 chr1:247681439 NA 0.47 7.65 0.39 2.24e-13 Acute lymphoblastic leukemia (childhood); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg22123729 chr4:54232041 SCFD2 0.41 5.98 0.31 5.85e-9 Response to antipsychotic treatment; CRC cis rs4908768 0.501 rs6577502 chr1:8615577 T/C cg20416874 chr1:8611966 RERE -0.46 -6.53 -0.34 2.49e-10 Neuroticism (multi-trait analysis);Subjective well-being (multi-trait analysis); CRC cis rs17767392 1.000 rs61991204 chr14:71768073 C/T cg13720639 chr14:72061746 SIPA1L1 -0.53 -6.81 -0.35 4.7e-11 Mitral valve prolapse; CRC cis rs2386661 0.826 rs10795723 chr10:5675983 C/T cg26603656 chr10:5671107 NA 0.55 9.16 0.45 5.86e-18 Breast cancer; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg25219047 chr19:3500813 DOHH 0.47 6.5 0.34 2.9e-10 Response to antipsychotic treatment; CRC cis rs9372498 0.536 rs62422220 chr6:118923731 G/A cg07617317 chr6:118971624 C6orf204 0.49 6.06 0.32 3.7e-9 Diastolic blood pressure; CRC cis rs3741798 1.000 rs17375328 chr12:12485292 T/C cg08615371 chr12:12503544 MANSC1 1.06 8.99 0.44 1.96e-17 Cerebrospinal fluid biomarker levels; CRC cis rs7843479 0.562 rs11774629 chr8:21859315 C/T cg16476235 chr8:21771668 DOK2 0.4 6.84 0.35 3.89e-11 Mean corpuscular volume; CRC cis rs375066 0.623 rs1549956 chr19:44354138 T/G cg19542119 chr19:44331823 ZNF283 0.4 5.61 0.3 4.24e-8 Breast cancer; CRC cis rs9322817 0.669 rs4079063 chr6:105266118 A/G cg02098413 chr6:105308735 HACE1 -0.44 -8.6 -0.43 3.29e-16 Thyroid stimulating hormone; CRC trans rs2235573 0.551 rs139893 chr22:38393608 G/A cg19894588 chr14:64061835 NA 0.53 7.41 0.38 1.1e-12 Glioblastoma;Glioma; CRC cis rs11608355 0.521 rs7972346 chr12:109808771 C/G cg19025524 chr12:109796872 NA 0.56 9.12 0.45 7.58e-18 Neuroticism; CRC cis rs2760061 0.717 rs708117 chr1:228199902 G/A cg18477163 chr1:228402036 OBSCN 0.4 6.8 0.35 5.08e-11 Diastolic blood pressure; CRC cis rs7809950 0.678 rs12672451 chr7:106853817 C/G cg23024343 chr7:107201750 COG5 -0.7 -9.48 -0.46 5.16e-19 Coronary artery disease; CRC cis rs847577 0.722 rs7790120 chr7:97712831 C/A cg21770322 chr7:97807741 LMTK2 0.83 18.33 0.71 3.32e-52 Breast cancer; CRC cis rs6860806 0.507 rs2631364 chr5:131706914 C/G cg27615366 chr5:131592974 PDLIM4 -0.33 -5.8 -0.3 1.57e-8 Breast cancer; CRC cis rs7666738 0.830 rs2865989 chr4:99067532 G/A cg05340658 chr4:99064831 C4orf37 0.6 9.33 0.46 1.57e-18 Colonoscopy-negative controls vs population controls; CRC cis rs7447927 0.950 rs13181561 chr5:138850905 A/G cg26929925 chr5:138714136 SLC23A1 -0.35 -5.75 -0.3 2.07e-8 Esophageal squamous cell carcinoma; CRC cis rs8180040 0.726 rs11130112 chr3:47024495 G/T cg27129171 chr3:47204927 SETD2 0.68 10.67 0.51 5e-23 Colorectal cancer; CRC cis rs4730250 0.707 rs257382 chr7:106804249 A/G cg02696742 chr7:106810147 HBP1 -0.6 -6.69 -0.35 9.69e-11 Osteoarthritis; CRC cis rs644799 0.710 rs519511 chr11:95538270 G/A cg03916912 chr11:95522834 CEP57;FAM76B 0.85 15.75 0.66 4.84e-42 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs950169 0.887 rs3860265 chr15:84945185 C/T cg11189052 chr15:85197271 WDR73 0.63 8.8 0.44 7.65e-17 Schizophrenia; CRC cis rs977987 0.806 rs11862684 chr16:75461746 T/G cg03315344 chr16:75512273 CHST6 0.55 9.12 0.45 7.92e-18 Dupuytren's disease; CRC cis rs4731207 0.698 rs1468378 chr7:124458359 C/A cg23710748 chr7:124431027 NA 0.38 6.08 0.32 3.42e-9 Cutaneous malignant melanoma; CRC cis rs12286929 0.589 rs4938190 chr11:115087750 C/T cg04055981 chr11:115044050 NA 0.37 5.65 0.3 3.55e-8 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs10193935 0.901 rs62142596 chr2:42529339 C/T cg27598129 chr2:42591480 NA -0.52 -6.46 -0.34 3.79e-10 Colonoscopy-negative controls vs population controls; CRC cis rs12586317 0.547 rs4982236 chr14:35468046 C/G cg05294307 chr14:35346193 BAZ1A -0.73 -8.21 -0.41 5.01e-15 Psoriasis; CRC cis rs1799949 1.000 rs1060915 chr17:41234470 A/G cg19454999 chr17:41278357 BRCA1;NBR2 0.55 8.47 0.42 8.2e-16 Menopause (age at onset); CRC cis rs4929949 0.901 rs4475924 chr11:8620009 T/C cg02811074 chr11:8615871 STK33 0.33 5.88 0.31 9.85e-9 Body mass index; CRC cis rs67311347 1.000 rs72861689 chr3:40435890 A/G cg09455208 chr3:40491958 NA 0.44 8.95 0.44 2.61e-17 Renal cell carcinoma; CRC cis rs1552172 0.811 rs12402787 chr1:145609971 T/C cg11743829 chr1:145714124 CD160 -0.42 -6.31 -0.33 9.18e-10 Breast cancer; CRC cis rs9322193 0.884 rs12528279 chr6:150072028 A/C cg00933542 chr6:150070202 PCMT1 0.33 6.97 0.36 1.73e-11 Lung cancer; CRC cis rs2797160 1.000 rs1777225 chr6:126018270 T/C cg05901451 chr6:126070800 HEY2 0.4 6.05 0.32 3.83e-9 Endometrial cancer; CRC cis rs7618915 0.501 rs7622694 chr3:52663882 G/A cg05573699 chr3:52720067 GNL3;PBRM1 -0.48 -7.03 -0.36 1.23e-11 Bipolar disorder; CRC cis rs9399137 0.507 rs56164974 chr6:135288716 C/T cg22676075 chr6:135203613 NA 0.59 8.93 0.44 3.16e-17 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; CRC cis rs4604732 0.642 rs4400652 chr1:247636479 A/G cg02104434 chr1:247694406 LOC148824;OR2C3 0.41 6.62 0.34 1.45e-10 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CRC trans rs55675132 0.548 rs79783412 chr1:115373478 G/A cg25493687 chr8:27288214 PTK2B 0.5 6.17 0.32 1.96e-9 Schizophrenia; CRC cis rs4822044 0.560 rs7284839 chr22:42010902 C/T cg03806693 chr22:41940476 POLR3H 1.07 12.59 0.57 6.34e-30 Cannabis dependence symptom count; CRC cis rs9311474 0.607 rs4475032 chr3:52560021 C/T cg08222913 chr3:52553049 STAB1 -0.37 -7.04 -0.36 1.1e-11 Electroencephalogram traits; CRC cis rs6952808 0.689 rs871924 chr7:2047845 A/G cg22963979 chr7:1858916 MAD1L1 -0.48 -7.09 -0.36 8.19e-12 Bipolar disorder and schizophrenia; CRC trans rs459571 0.839 rs2519831 chr9:136886257 T/A cg15028160 chr19:49622717 PPFIA3;C19orf73 -0.59 -7.36 -0.38 1.45e-12 Platelet distribution width; CRC trans rs12599106 0.818 rs17723574 chr16:34602945 C/G cg26668828 chr6:292823 DUSP22 -0.58 -8.68 -0.43 1.82e-16 Menopause (age at onset); CRC cis rs9911578 0.967 rs12944948 chr17:56951474 A/G cg12560992 chr17:57184187 TRIM37 0.92 17.0 0.68 6.03e-47 Intelligence (multi-trait analysis); CRC cis rs6502050 0.835 rs3935816 chr17:80137173 C/T cg13198984 chr17:80129470 CCDC57 0.44 7.63 0.39 2.49e-13 Life satisfaction; CRC trans rs9388451 1.000 rs9388451 chr6:126090377 A/G cg05039488 chr6:79577232 IRAK1BP1 -0.54 -8.28 -0.42 3.06e-15 Brugada syndrome; CRC trans rs7647973 0.677 rs11130211 chr3:49645209 C/T cg21665057 chr3:196295764 WDR53;FBXO45 -0.65 -7.03 -0.36 1.17e-11 Menarche (age at onset); CRC cis rs736801 0.754 rs2706336 chr5:131799961 T/C cg02033258 chr5:131593261 PDLIM4 -0.34 -5.96 -0.31 6.66e-9 Breast cancer;Mosquito bite size; CRC cis rs853679 0.517 rs4713141 chr6:28101678 G/C cg12273811 chr6:28175739 NA 0.73 9.36 0.46 1.34e-18 Depression; CRC cis rs1997103 0.954 rs56030000 chr7:55405750 A/G cg17469321 chr7:55412551 NA 0.72 11.28 0.53 3.48e-25 QRS interval (sulfonylurea treatment interaction); CRC cis rs2204008 0.668 rs1619009 chr12:38120485 G/A cg26384229 chr12:38710491 ALG10B -0.56 -8.38 -0.42 1.53e-15 Bladder cancer; CRC cis rs34172651 0.917 rs35283675 chr16:24820393 A/G cg00339695 chr16:24857497 SLC5A11 0.27 6.09 0.32 3.11e-9 Intelligence (multi-trait analysis); CRC cis rs875971 1.000 rs778694 chr7:65871558 A/G cg11764359 chr7:65958608 NA 0.61 9.95 0.48 1.41e-20 Aortic root size; CRC cis rs1005277 0.579 rs2474608 chr10:38457109 C/T cg25517755 chr10:38738941 LOC399744 -0.43 -6.3 -0.33 9.65e-10 Extrinsic epigenetic age acceleration; CRC cis rs6963495 0.745 rs818620 chr7:105172685 G/C cg19920283 chr7:105172520 RINT1 0.54 6.66 0.34 1.12e-10 Bipolar disorder (body mass index interaction); CRC cis rs7811142 1.000 rs74460138 chr7:100027339 C/G cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.98 13.51 0.6 2.08e-33 Platelet count; CRC cis rs9443645 0.901 rs2050663 chr6:79753394 T/C cg11833968 chr6:79620685 NA -0.35 -5.95 -0.31 7.05e-9 Intelligence (multi-trait analysis); CRC cis rs2404602 0.692 rs12910382 chr15:77053442 A/C cg23625390 chr15:77176239 SCAPER 0.48 6.83 0.35 4.16e-11 Blood metabolite levels; CRC trans rs916888 0.610 rs199454 chr17:44800110 G/A cg01341218 chr17:43662625 NA -0.57 -7.43 -0.38 9.51e-13 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs9515201 0.627 rs4773173 chr13:111025118 A/G cg15455643 chr13:111040242 COL4A2 0.34 5.64 0.3 3.65e-8 White matter hyperintensity burden; CRC cis rs11997175 0.766 rs7387133 chr8:33727045 C/G ch.8.33884649F chr8:33765107 NA -0.41 -6.03 -0.32 4.28e-9 Body mass index; CRC cis rs55788414 0.932 rs9929253 chr16:81181641 C/T cg06400318 chr16:81190750 PKD1L2 -0.55 -6.45 -0.33 4.04e-10 Left ventricular obstructive tract defect (maternal effect); CRC cis rs929354 0.742 rs10274687 chr7:156933181 T/G cg05182265 chr7:156933206 UBE3C -0.76 -14.38 -0.62 1.04e-36 Body mass index; CRC cis rs17384381 1.000 rs12138852 chr1:85878208 C/T cg16011679 chr1:85725395 C1orf52 0.65 6.68 0.35 1.05e-10 Lobe attachment (rater-scored or self-reported); CRC cis rs6546550 0.933 rs6546554 chr2:70135706 G/A cg02498382 chr2:70120550 SNRNP27 -0.56 -9.52 -0.46 3.78e-19 Prevalent atrial fibrillation; CRC cis rs4713118 0.955 rs9393847 chr6:27687973 G/A cg06470822 chr6:28175283 NA 0.68 9.05 0.45 1.29e-17 Parkinson's disease; CRC cis rs9322193 0.962 rs3805748 chr6:150093678 C/T cg05861140 chr6:150128134 PCMT1 -0.41 -6.59 -0.34 1.7e-10 Lung cancer; CRC cis rs12220238 1.000 rs12252705 chr10:75984863 A/G cg19889307 chr10:75911429 ADK;AP3M1 0.56 5.73 0.3 2.23e-8 Soluble interleukin-2 receptor subunit alpha; CRC cis rs2625529 0.529 rs1552133 chr15:72232897 T/A cg16672083 chr15:72433130 SENP8 0.47 6.96 0.36 1.9e-11 Red blood cell count; CRC cis rs7605827 0.866 rs2032692 chr2:15616847 A/G cg19274914 chr2:15703543 NA 0.37 5.7 0.3 2.64e-8 Educational attainment (years of education); CRC cis rs73198271 0.562 rs113730597 chr8:8651573 G/A cg01851573 chr8:8652454 MFHAS1 0.56 7.08 0.36 8.86e-12 Bone ultrasound measurement (broadband ultrasound attenuation); CRC cis rs2012796 1.000 rs8008024 chr14:81818492 A/G cg02996355 chr14:81879375 NA 0.56 8.08 0.41 1.21e-14 Night sleep phenotypes; CRC cis rs6693567 0.826 rs1260387 chr1:150371448 T/C cg17724175 chr1:150552817 MCL1 -0.5 -7.29 -0.37 2.29e-12 Migraine; CRC cis rs1218582 0.772 rs6686873 chr1:154913404 C/G cg09359103 chr1:154839909 KCNN3 -0.7 -12.3 -0.56 7.41e-29 Prostate cancer; CRC cis rs4380275 0.931 rs4538239 chr2:774238 C/T cg27237671 chr2:676223 TMEM18 -0.43 -6.18 -0.32 1.95e-9 Adverse response to chemotherapy (neutropenia/leucopenia) (doxorubicin); CRC cis rs929354 0.739 rs12533082 chr7:157014172 T/A cg16102536 chr7:156981717 UBE3C 0.4 6.79 0.35 5.41e-11 Body mass index; CRC trans rs6011368 0.749 rs4809418 chr20:62915231 G/A cg13869341 chr1:15865 WASH5P -0.53 -8.1 -0.41 1.06e-14 Clozapine-induced cytotoxicity; CRC cis rs2120019 0.938 rs8040169 chr15:75370958 C/A cg17294928 chr15:75287854 SCAMP5 -0.73 -10.92 -0.52 6.61e-24 Blood trace element (Zn levels); CRC cis rs7215564 0.908 rs901066 chr17:78659617 C/G cg09596252 chr17:78655493 RPTOR 0.54 5.81 0.3 1.48e-8 Myopia (pathological); CRC cis rs58688157 0.705 rs7122021 chr11:595810 A/G cg09218773 chr11:619014 MUPCDH -0.43 -6.34 -0.33 7.78e-10 Systemic lupus erythematosus; CRC cis rs4974559 0.895 rs10004411 chr4:1354306 T/G cg02980000 chr4:1222292 CTBP1 0.75 9.68 0.47 1.12e-19 Systolic blood pressure; CRC cis rs7927771 0.896 rs12794570 chr11:47658314 C/T cg05585544 chr11:47624801 NA -0.62 -11.44 -0.53 9.35e-26 Subjective well-being; CRC cis rs10208940 0.920 rs6708618 chr2:68722597 C/A cg12452813 chr2:68675892 NA 0.5 6.17 0.32 2e-9 Urate levels in lean individuals; CRC cis rs6952808 0.771 rs10275045 chr7:1920826 C/T cg04267008 chr7:1944627 MAD1L1 -0.68 -10.48 -0.5 2.37e-22 Bipolar disorder and schizophrenia; CRC trans rs6546324 0.580 rs4362541 chr2:67842866 A/T cg00907274 chr3:27498161 SLC4A7 -0.48 -6.1 -0.32 3.03e-9 Endometriosis; CRC cis rs8005677 0.828 rs12589539 chr14:23396680 A/G cg25600027 chr14:23388339 RBM23 -0.45 -6.84 -0.35 3.96e-11 Cognitive ability (multi-trait analysis); CRC cis rs67311347 1.000 rs7633809 chr3:40517737 A/G cg24209194 chr3:40518798 ZNF619 -0.41 -6.06 -0.32 3.78e-9 Renal cell carcinoma; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg11750756 chr12:50135418 TMBIM6 0.54 7.13 0.37 6.31e-12 Thyroid stimulating hormone; CRC cis rs2153535 0.580 rs7341382 chr6:8470549 A/G cg07606381 chr6:8435919 SLC35B3 0.68 10.9 0.51 8.26e-24 Motion sickness; CRC cis rs9976767 0.792 rs883868 chr21:43845092 C/T cg23042151 chr21:43824109 UBASH3A 0.37 6.44 0.33 4.29e-10 Type 1 diabetes; CRC cis rs6952808 0.595 rs3778984 chr7:2166514 T/C cg22963979 chr7:1858916 MAD1L1 -0.46 -6.47 -0.34 3.57e-10 Bipolar disorder and schizophrenia; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg05340844 chr15:90808742 NGRN 0.5 6.33 0.33 7.95e-10 Thyroid stimulating hormone; CRC cis rs2032447 0.736 rs115810 chr6:25975883 G/C cg26028573 chr6:26043587 HIST1H2BB 0.52 7.59 0.39 3.41e-13 Intelligence (multi-trait analysis); CRC cis rs7605827 0.930 rs3732004 chr2:15713783 C/T cg19274914 chr2:15703543 NA 0.41 6.15 0.32 2.25e-9 Educational attainment (years of education); CRC trans rs7267979 1.000 rs6050630 chr20:25430745 A/G cg17903999 chr18:56338584 MALT1 -0.42 -6.98 -0.36 1.6e-11 Liver enzyme levels (alkaline phosphatase); CRC cis rs7618501 0.699 rs2681780 chr3:49897830 C/T cg24308560 chr3:49941425 MST1R -0.51 -7.95 -0.4 2.93e-14 Intelligence (multi-trait analysis); CRC cis rs208515 0.525 rs4145045 chr6:66678949 T/C cg07460842 chr6:66804631 NA 0.93 11.66 0.54 1.56e-26 Exhaled nitric oxide levels; CRC cis rs6456156 0.819 rs9457273 chr6:167520749 A/T cg07741184 chr6:167504864 NA -0.46 -7.88 -0.4 4.9e-14 Primary biliary cholangitis; CRC cis rs28386778 0.897 rs2236737 chr17:61938100 C/T cg25654072 chr17:61904446 PSMC5;FTSJ3 0.69 10.67 0.51 4.87e-23 Prudent dietary pattern; CRC cis rs7927771 0.826 rs7925389 chr11:47466790 A/T cg18512352 chr11:47633146 NA -0.41 -7.91 -0.4 3.94e-14 Subjective well-being; CRC cis rs524281 0.861 rs7120326 chr11:65849256 C/T cg14036092 chr11:66035641 RAB1B -0.48 -5.8 -0.3 1.58e-8 Electroencephalogram traits; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg25201980 chr8:146127417 ZNF250 0.48 6.72 0.35 8.25e-11 Response to antipsychotic treatment; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg02522952 chr6:119671260 MAN1A1 0.4 6.55 0.34 2.17e-10 Liver disease severity in Alagille syndrome; CRC cis rs9868809 0.649 rs3733086 chr3:48699519 C/T cg00383909 chr3:49044727 WDR6 0.85 8.03 0.4 1.7e-14 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; CRC cis rs59901009 0.911 rs61889955 chr11:10183445 G/T cg23875677 chr11:10229755 SBF2 -0.46 -5.68 -0.3 3e-8 Hematocrit;Hemoglobin concentration; CRC trans rs800082 1.000 rs9882503 chr3:144321296 A/T cg24215973 chr2:240111563 HDAC4 -0.53 -7.52 -0.38 5.16e-13 Smoking behavior; CRC cis rs11758351 1.000 rs80095925 chr6:26184942 C/T cg01420254 chr6:26195488 NA 0.89 9.07 0.45 1.11e-17 Gout;Renal underexcretion gout; CRC cis rs2067615 0.542 rs7133161 chr12:107139540 A/G cg13491945 chr12:107078410 RFX4 0.34 5.84 0.31 1.25e-8 Heart rate; CRC cis rs9649213 0.593 rs6949718 chr7:97924483 G/A cg24562669 chr7:97807699 LMTK2 0.44 7.25 0.37 2.95e-12 Prostate cancer (SNP x SNP interaction); CRC cis rs10504229 0.545 rs56394419 chr8:58128982 T/C cg22535103 chr8:58192502 C8orf71 -0.7 -9.34 -0.46 1.47e-18 Developmental language disorder (linguistic errors); CRC cis rs6952808 0.965 rs4719318 chr7:1887930 G/A cg20295408 chr7:1910781 MAD1L1 -0.44 -6.4 -0.33 5.26e-10 Bipolar disorder and schizophrenia; CRC cis rs9443645 0.901 rs10455356 chr6:79664748 T/C cg05283184 chr6:79620031 NA -0.58 -9.17 -0.45 5.11e-18 Intelligence (multi-trait analysis); CRC cis rs916888 0.610 rs199438 chr17:44791643 G/A cg15921436 chr17:44337874 NA 0.51 6.43 0.33 4.45e-10 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs28386778 0.897 rs7210443 chr17:61785374 A/G cg07362569 chr17:61921086 SMARCD2 0.37 5.7 0.3 2.72e-8 Prudent dietary pattern; CRC cis rs3859192 0.599 rs12451897 chr17:38179275 G/T cg17467752 chr17:38218738 THRA -0.51 -7.52 -0.38 5.32e-13 White blood cell count; CRC cis rs10736390 0.640 rs10888858 chr1:55108978 A/G cg01517571 chr1:55089959 ACOT11;FAM151A -0.91 -15.88 -0.66 1.45e-42 Survival in pancreatic cancer; CRC cis rs3849570 0.961 rs13340130 chr3:81790970 A/T cg07356753 chr3:81810745 GBE1 -0.74 -11.2 -0.53 7.03e-25 Waist circumference;Body mass index; CRC cis rs9467773 1.000 rs1056667 chr6:26510564 T/C cg09904177 chr6:26538194 HMGN4 0.85 14.75 0.63 3.95e-38 Intelligence (multi-trait analysis); CRC cis rs6540559 1.000 rs742214 chr1:209960925 T/C cg23283495 chr1:209979779 IRF6 0.46 7.03 0.36 1.22e-11 Cleft lip with or without cleft palate; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg27263386 chr21:33984714 C21orf59 0.5 7.2 0.37 4.11e-12 Response to antipsychotic treatment; CRC cis rs7771547 0.519 rs12202691 chr6:36377820 G/A cg07856975 chr6:36356162 ETV7 0.47 5.87 0.31 1.06e-8 Platelet distribution width; CRC trans rs7746199 0.668 rs34864796 chr6:27459923 G/A cg06606381 chr12:133084897 FBRSL1 -0.84 -6.75 -0.35 6.61e-11 Gait speed in old age;Autism spectrum disorder or schizophrenia; CRC cis rs9326248 0.559 rs484646 chr11:116732856 A/G cg20608306 chr11:116969690 SIK3 0.35 7.33 0.37 1.76e-12 Blood protein levels; CRC trans rs1499614 0.803 rs1796229 chr7:66119661 G/A cg10756647 chr7:56101905 PSPH 0.76 8.08 0.41 1.26e-14 Gout; CRC trans rs35110281 0.837 rs2838341 chr21:45076443 A/G cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.43 6.93 0.36 2.2e-11 Mean corpuscular volume; CRC trans rs1814175 0.669 rs11040455 chr11:49669829 G/C cg03929089 chr4:120376271 NA -0.72 -11.74 -0.54 8.32e-27 Height; CRC cis rs847577 0.722 rs7790736 chr7:97713039 G/A cg24562669 chr7:97807699 LMTK2 0.76 16.52 0.67 4.67e-45 Breast cancer; CRC trans rs3942852 0.726 rs1503171 chr11:48175152 T/C cg15704280 chr7:45808275 SEPT13 -0.75 -9.35 -0.46 1.43e-18 Acute lymphoblastic leukemia (childhood); CRC cis rs651907 0.535 rs17347156 chr3:101504674 G/A cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.59 7.87 0.4 5.08e-14 Colorectal cancer; CRC cis rs6951245 0.872 rs75280240 chr7:1058511 C/T cg18402987 chr7:1209562 NA 0.59 6.21 0.32 1.56e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs4664304 1.000 rs55977890 chr2:160776866 C/T cg03641300 chr2:160917029 PLA2R1 -0.39 -5.68 -0.3 2.93e-8 Crohn's disease;Inflammatory bowel disease; CRC cis rs2228479 0.850 rs2238532 chr16:89863672 T/C cg19635926 chr16:89946313 TCF25 0.66 6.17 0.32 1.99e-9 Skin colour saturation; CRC cis rs2153904 0.793 rs71633563 chr1:205735854 C/T cg23034840 chr1:205782522 SLC41A1 -0.52 -5.83 -0.31 1.31e-8 Prostate-specific antigen levels; CRC cis rs9322193 0.884 rs9383865 chr6:150173179 A/G cg13206674 chr6:150067644 NUP43 0.58 8.29 0.42 2.99e-15 Lung cancer; CRC trans rs6951245 0.554 rs10246354 chr7:1132456 C/T cg13565492 chr6:43139072 SRF -0.84 -10.54 -0.5 1.46e-22 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs7727544 0.716 rs4705928 chr5:131578637 A/G cg12564285 chr5:131593104 PDLIM4 -0.38 -7.11 -0.37 7.08e-12 Blood metabolite levels; CRC cis rs7618915 0.501 rs1866268 chr3:52719398 C/A cg18099408 chr3:52552593 STAB1 -0.47 -8.01 -0.4 2.01e-14 Bipolar disorder; CRC cis rs28386778 0.897 rs1062787 chr17:61896004 T/C cg25654072 chr17:61904446 PSMC5;FTSJ3 0.74 11.51 0.54 5.33e-26 Prudent dietary pattern; CRC cis rs7833986 1.000 rs56699713 chr8:57096670 C/T cg23139584 chr8:56987506 RPS20;SNORD54 0.53 6.81 0.35 4.56e-11 Height; CRC cis rs1881396 0.947 rs8731 chr2:27873326 C/G cg27432699 chr2:27873401 GPN1 0.63 8.07 0.41 1.3e-14 Nonalcoholic fatty liver disease; CRC cis rs853679 0.517 rs9393885 chr6:28050009 A/T cg18032046 chr6:28092343 ZSCAN16 -0.51 -6.05 -0.32 3.87e-9 Depression; CRC cis rs4481887 0.927 rs4427440 chr1:248480337 T/A cg13385794 chr1:248469461 NA 0.38 6.67 0.35 1.09e-10 Common traits (Other); CRC cis rs977987 0.806 rs11864102 chr16:75442360 C/T cg03315344 chr16:75512273 CHST6 0.54 9.08 0.45 1.04e-17 Dupuytren's disease; CRC cis rs35306767 0.714 rs7072554 chr10:1090988 C/T cg26597838 chr10:835615 NA 0.63 8.28 0.42 3.12e-15 Eosinophil percentage of granulocytes; CRC cis rs1059312 1.000 rs1059312 chr12:129278864 A/G cg09035930 chr12:129282057 SLC15A4 -0.54 -9.1 -0.45 8.54e-18 Systemic lupus erythematosus; CRC cis rs10256972 0.721 rs2030959 chr7:1075906 T/C cg02869364 chr7:1081709 C7orf50 -0.38 -6.06 -0.32 3.72e-9 Longevity;Endometriosis; CRC cis rs6502050 0.842 rs7211808 chr17:80071244 T/C cg02741985 chr17:80059408 CCDC57 -0.42 -6.7 -0.35 9.15e-11 Life satisfaction; CRC trans rs529967 0.797 rs555540 chr3:124166965 A/C cg01377916 chr16:46654868 SHCBP1 -0.46 -6.34 -0.33 7.68e-10 Acute graft versus host disease in bone marrow transplantation (donor effect); CRC cis rs2530545 0.619 rs6955936 chr7:34662450 C/T cg14401837 chr7:34697493 NPSR1 0.42 6.27 0.33 1.14e-9 IgG glycosylation; CRC cis rs7666738 0.830 rs62321570 chr4:98984276 G/A cg05340658 chr4:99064831 C4orf37 0.6 9.41 0.46 8.57e-19 Colonoscopy-negative controls vs population controls; CRC cis rs12477438 0.520 rs2632277 chr2:99778985 A/G cg14399236 chr2:99771627 LIPT1;TSGA10 0.81 14.59 0.63 1.54e-37 Chronic sinus infection; CRC cis rs7512552 0.839 rs486275 chr1:150282784 G/A cg15654264 chr1:150340011 RPRD2 -0.57 -7.92 -0.4 3.63e-14 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); CRC cis rs7824557 0.527 rs2736298 chr8:11235136 C/G cg20542592 chr8:11973495 FAM66D 0.32 5.69 0.3 2.81e-8 Retinal vascular caliber; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg07718463 chr19:30303131 CCNE1 0.49 7.45 0.38 8.05e-13 Liver disease severity in Alagille syndrome; CRC cis rs4713118 0.515 rs9368549 chr6:28050047 T/A cg12273811 chr6:28175739 NA 0.71 9.2 0.45 4.28e-18 Parkinson's disease; CRC cis rs6502050 0.835 rs7212441 chr17:80080047 T/G cg09264619 chr17:80180166 NA 0.37 6.13 0.32 2.47e-9 Life satisfaction; CRC cis rs13256369 1.000 rs13266699 chr8:8570313 A/T cg00074818 chr8:8560427 CLDN23 -0.43 -7.92 -0.4 3.58e-14 Obesity-related traits; CRC cis rs1552244 0.882 rs2030564 chr3:10039044 A/G cg00166722 chr3:10149974 C3orf24 0.61 8.03 0.4 1.76e-14 Alzheimer's disease; CRC cis rs9908102 0.740 rs8078710 chr17:12910662 G/A cg26162695 chr17:12921313 ELAC2 0.43 5.85 0.31 1.17e-8 Schizophrenia; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg22162010 chr1:113249994 RHOC -0.37 -6.13 -0.32 2.49e-9 Myopia (pathological); CRC cis rs10256972 0.516 rs12702081 chr7:1141528 T/C cg18402987 chr7:1209562 NA 0.46 6.69 0.35 9.76e-11 Longevity;Endometriosis; CRC cis rs6582630 0.679 rs10785514 chr12:38573689 T/C cg26384229 chr12:38710491 ALG10B 0.45 6.46 0.34 3.7e-10 Drug-induced liver injury (flucloxacillin); CRC cis rs1552244 0.938 rs7652951 chr3:10063763 A/C cg16606324 chr3:10149918 C3orf24 0.69 9.43 0.46 7.91e-19 Alzheimer's disease; CRC cis rs1552244 1.000 rs2160869 chr3:10079255 G/A cg08888203 chr3:10149979 C3orf24 0.7 10.06 0.49 6.03e-21 Alzheimer's disease; CRC cis rs9911578 1.000 rs12952832 chr17:56906254 T/C cg05425664 chr17:57184151 TRIM37 -0.49 -7.73 -0.39 1.33e-13 Intelligence (multi-trait analysis); CRC cis rs7119 0.931 rs12901998 chr15:77833524 G/T cg10437265 chr15:77819839 NA 0.58 10.42 0.5 3.62e-22 Type 2 diabetes; CRC cis rs9486715 0.838 rs9486275 chr6:96901187 C/T cg18709589 chr6:96969512 KIAA0776 0.49 7.26 0.37 2.75e-12 Headache; CRC cis rs3091242 0.728 rs706845 chr1:25730713 G/A cg20684491 chr1:25596433 NA 0.4 6.85 0.35 3.61e-11 Erythrocyte sedimentation rate; CRC cis rs1552244 0.882 rs7636817 chr3:10014876 G/T cg16606324 chr3:10149918 C3orf24 0.61 7.94 0.4 3.33e-14 Alzheimer's disease; CRC cis rs7811142 1.000 rs11559117 chr7:100076614 A/G cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.08 15.27 0.64 3.58e-40 Platelet count; CRC cis rs9937943 0.667 rs11862508 chr16:74598688 T/C cg01733217 chr16:74700730 RFWD3 0.72 8.18 0.41 6.38e-15 Neutrophil percentage of white cells; CRC cis rs9303401 0.614 rs17175663 chr17:57108437 G/C cg10487724 chr17:56770010 TEX14;RAD51C 0.76 8.94 0.44 2.77e-17 Cognitive test performance; CRC cis rs3806843 0.735 rs2530241 chr5:140054485 C/T cg19875535 chr5:140030758 IK -0.64 -10.4 -0.5 4.36e-22 Depressive symptoms (multi-trait analysis); CRC cis rs11098499 0.863 rs10019674 chr4:120443489 C/T cg09307838 chr4:120376055 NA -0.68 -10.06 -0.49 6.09e-21 Corneal astigmatism; CRC cis rs17376456 0.877 rs13169675 chr5:93331284 A/G cg21475434 chr5:93447410 FAM172A 0.8 7.94 0.4 3.32e-14 Diabetic retinopathy; CRC cis rs2070488 0.804 rs7646429 chr3:38467713 A/G cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.78 13.36 0.59 7.84e-33 Electrocardiographic conduction measures; CRC cis rs1862618 0.853 rs3099459 chr5:56137170 G/C cg12311346 chr5:56204834 C5orf35 -0.79 -10.41 -0.5 4.06e-22 Initial pursuit acceleration; CRC cis rs1448094 0.511 rs11117042 chr12:86207547 G/T cg02569458 chr12:86230093 RASSF9 0.44 7.6 0.39 3.08e-13 Major depressive disorder; CRC trans rs3733585 0.631 rs4697924 chr4:10124239 A/G cg26043149 chr18:55253948 FECH -0.5 -6.8 -0.35 4.9e-11 Cleft plate (environmental tobacco smoke interaction); CRC cis rs172166 0.694 rs188105 chr6:28071393 C/T cg12172441 chr6:28176163 NA 0.53 7.32 0.37 1.96e-12 Cardiac Troponin-T levels; CRC cis rs12908161 0.959 rs11637728 chr15:85203392 A/T cg11189052 chr15:85197271 WDR73 0.64 9.22 0.45 3.73e-18 Schizophrenia; CRC trans rs7824557 0.670 rs2736381 chr8:11132766 A/T cg06636001 chr8:8085503 FLJ10661 -0.44 -6.16 -0.32 2.13e-9 Retinal vascular caliber; CRC cis rs12983728 0.831 rs35081008 chr19:58662235 C/T cg12792011 chr19:58661915 ZNF329 0.75 8.19 0.41 5.94e-15 Cholesterol, total; CRC cis rs929354 0.605 rs7806314 chr7:156946903 A/T cg17757837 chr7:157058334 UBE3C 0.74 12.39 0.56 3.31e-29 Body mass index; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg05210131 chr2:182757482 SSFA2 0.39 6.14 0.32 2.39e-9 Liver disease severity in Alagille syndrome; CRC cis rs769267 0.930 rs1054930 chr19:19648346 G/C cg01262667 chr19:19385393 TM6SF2 0.37 6.03 0.32 4.41e-9 Tonsillectomy; CRC cis rs13315871 1.000 rs11717423 chr3:58330177 C/G cg20936604 chr3:58311152 NA -0.76 -7.27 -0.37 2.69e-12 Cholesterol, total; CRC trans rs7267979 1.000 rs6515651 chr20:25414539 T/G cg17903999 chr18:56338584 MALT1 0.41 6.71 0.35 8.45e-11 Liver enzyme levels (alkaline phosphatase); CRC cis rs12956009 0.583 rs11663609 chr18:44862757 C/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.39 6.07 0.32 3.44e-9 Educational attainment (years of education); CRC cis rs4713118 0.869 rs9393851 chr6:27699581 A/T cg19041857 chr6:27730383 NA -0.41 -6.0 -0.31 5.3300000000000004e-09 Parkinson's disease; CRC cis rs7927771 0.524 rs2242081 chr11:47500267 T/C cg20307385 chr11:47447363 PSMC3 0.53 7.69 0.39 1.69e-13 Subjective well-being; CRC trans rs8002861 0.870 rs4942251 chr13:44440048 G/T cg17145862 chr1:211918768 LPGAT1 0.71 14.1 0.61 1.26e-35 Leprosy; CRC cis rs524281 0.773 rs7925123 chr11:65993213 G/C cg14036092 chr11:66035641 RAB1B -0.56 -6.35 -0.33 7.22e-10 Electroencephalogram traits; CRC cis rs12477438 0.798 rs6740267 chr2:99561867 T/C cg14399236 chr2:99771627 LIPT1;TSGA10 -0.7 -9.72 -0.47 8.49e-20 Chronic sinus infection; CRC cis rs516243 0.871 rs3748687 chr1:10736216 G/A cg02903756 chr1:10750680 CASZ1 -0.47 -7.91 -0.4 3.87e-14 Migraine - clinic-based; CRC cis rs10504229 0.645 rs35142596 chr8:58128151 C/T cg22535103 chr8:58192502 C8orf71 -0.7 -9.34 -0.46 1.47e-18 Developmental language disorder (linguistic errors); CRC cis rs8014204 0.804 rs2241274 chr14:75251331 G/A cg03030879 chr14:75389066 RPS6KL1 -0.5 -8.04 -0.41 1.69e-14 Caffeine consumption; CRC cis rs7264396 0.635 rs6060709 chr20:34536022 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.6 -9.73 -0.47 7.66e-20 Total cholesterol levels; CRC cis rs9522267 0.535 rs9522298 chr13:112234457 C/A cg10483660 chr13:112241077 NA -0.48 -8.99 -0.44 2.04e-17 Hepatitis; CRC cis rs6860806 0.531 rs2631359 chr5:131707892 C/T cg12564285 chr5:131593104 PDLIM4 -0.45 -7.62 -0.39 2.67e-13 Breast cancer; CRC cis rs12701220 0.655 rs6955290 chr7:1151066 A/G cg02733842 chr7:1102375 C7orf50 0.61 7.78 0.39 9.31e-14 Bronchopulmonary dysplasia; CRC cis rs12681287 0.608 rs2953511 chr8:87340870 G/A cg27223183 chr8:87520930 FAM82B -0.53 -7.05 -0.36 1.04e-11 Caudate activity during reward; CRC cis rs7932354 0.583 rs6485695 chr11:46836165 C/T cg19486271 chr11:47235900 DDB2 -0.42 -6.08 -0.32 3.31e-9 Bone mineral density (hip);Bone mineral density; CRC cis rs4975616 0.686 rs37008 chr5:1351538 C/T cg06550200 chr5:1325588 CLPTM1L -0.65 -10.0 -0.48 1.02e-20 Lung cancer; CRC cis rs1018836 0.923 rs6988733 chr8:91535686 C/T cg16814680 chr8:91681699 NA -0.75 -12.27 -0.56 9.35e-29 Ejection fraction in Tripanosoma cruzi seropositivity; CRC cis rs9487051 0.714 rs6903695 chr6:109631422 C/G cg21918786 chr6:109611834 NA 0.38 6.69 0.35 9.62e-11 Reticulocyte fraction of red cells; CRC cis rs755249 0.567 rs1126313 chr1:39639744 A/C cg18385671 chr1:39797026 MACF1 0.41 5.77 0.3 1.86e-8 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs6502050 0.769 rs9898542 chr17:80119682 C/T cg13198984 chr17:80129470 CCDC57 0.47 8.35 0.42 1.88e-15 Life satisfaction; CRC cis rs7666738 0.830 rs10034619 chr4:98970067 G/C cg17366294 chr4:99064904 C4orf37 0.44 7.32 0.37 1.94e-12 Colonoscopy-negative controls vs population controls; CRC trans rs3960554 0.529 rs7800970 chr7:75880198 C/T cg19862616 chr7:65841803 NCRNA00174 -0.48 -6.73 -0.35 7.46e-11 Eotaxin levels; CRC cis rs9837602 1.000 rs4075038 chr3:99680086 A/G cg07805332 chr3:99536008 MIR548G;C3orf26 0.47 6.36 0.33 6.86e-10 Breast cancer; CRC cis rs9372498 0.536 rs9489399 chr6:118767147 C/A cg10217327 chr6:118973057 C6orf204 0.51 5.73 0.3 2.29e-8 Diastolic blood pressure; CRC trans rs7267979 1.000 rs2258563 chr20:25273435 C/T cg17903999 chr18:56338584 MALT1 -0.42 -6.94 -0.36 2.05e-11 Liver enzyme levels (alkaline phosphatase); CRC cis rs478304 0.934 rs574483 chr11:65515277 A/G cg08755490 chr11:65554678 OVOL1 0.44 6.34 0.33 7.57e-10 Acne (severe); CRC cis rs1552244 1.000 rs3895942 chr3:10108745 G/C cg18598329 chr3:10140678 FANCD2;C3orf24 -0.87 -12.07 -0.55 5.3e-28 Alzheimer's disease; CRC cis rs992157 0.735 rs12990082 chr2:219102332 C/T cg04731861 chr2:219085781 ARPC2 -0.32 -6.78 -0.35 5.56e-11 Colorectal cancer; CRC cis rs10504229 0.953 rs57669205 chr8:58172253 T/C cg22535103 chr8:58192502 C8orf71 -0.82 -12.24 -0.56 1.18e-28 Developmental language disorder (linguistic errors); CRC cis rs936229 0.654 rs762551 chr15:75041917 C/A cg14664628 chr15:75095509 CSK -0.9 -15.13 -0.64 1.32e-39 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); CRC cis rs751728 1.000 rs4711351 chr6:33754592 G/A cg25922239 chr6:33757077 LEMD2 0.63 9.6 0.47 2.18e-19 Crohn's disease; CRC cis rs7917772 0.636 rs2863718 chr10:104519631 G/C cg22532475 chr10:104410764 TRIM8 0.33 5.71 0.3 2.53e-8 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC cis rs796364 0.806 rs11684942 chr2:201009136 C/T cg25936922 chr2:200820526 C2orf60;C2orf47 -0.65 -6.15 -0.32 2.23e-9 Schizophrenia; CRC cis rs9807841 0.592 rs6511707 chr19:10767790 C/T cg17710535 chr19:10819994 QTRT1 0.45 6.29 0.33 1.01e-9 Inflammatory skin disease; CRC cis rs7112925 0.738 rs12803688 chr11:66833265 G/A cg24851651 chr11:66362959 CCS -0.33 -5.74 -0.3 2.15e-8 Height; CRC cis rs28386778 0.897 rs1062787 chr17:61896004 T/C cg06873352 chr17:61820015 STRADA 0.8 15.25 0.64 4.21e-40 Prudent dietary pattern; CRC trans rs9858542 0.953 rs9859556 chr3:49455986 G/T cg21582582 chr3:182698605 DCUN1D1 -0.5 -6.31 -0.33 9.06e-10 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs9372498 0.536 rs1319987 chr6:118782236 A/G cg22561889 chr6:118971681 C6orf204 0.52 6.7 0.35 9.08e-11 Diastolic blood pressure; CRC cis rs116095464 0.558 rs10036253 chr5:238519 A/C cg22496380 chr5:211416 CCDC127 -0.91 -10.38 -0.5 5.2e-22 Breast cancer; CRC cis rs6496044 0.611 rs6496055 chr15:86070688 A/G cg17133734 chr15:86042851 AKAP13 0.4 6.48 0.34 3.44e-10 Interstitial lung disease; CRC cis rs6089584 0.566 rs2181589 chr20:60622817 C/T cg23262073 chr20:60523788 NA 0.38 6.45 0.33 4.06e-10 Body mass index; CRC cis rs10504229 0.906 rs56138544 chr8:58184558 A/C cg02725872 chr8:58115012 NA -0.38 -6.43 -0.33 4.44e-10 Developmental language disorder (linguistic errors); CRC trans rs7615952 0.800 rs12489350 chr3:125644116 T/C cg02007433 chr3:129722099 NA -0.47 -6.46 -0.34 3.74e-10 Blood pressure (smoking interaction); CRC cis rs4803468 0.934 rs11880674 chr19:41889423 A/T cg09537434 chr19:41945824 ATP5SL -0.9 -17.62 -0.7 2.16e-49 Height; CRC cis rs736408 0.774 rs4687551 chr3:52823448 C/T cg15147215 chr3:52552868 STAB1 0.54 8.16 0.41 7.07e-15 Bipolar disorder; CRC cis rs10924970 0.934 rs3856241 chr1:235429692 G/A cg26050004 chr1:235667680 B3GALNT2 0.39 5.8 0.3 1.53e-8 Asthma; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg00162206 chr2:113239913 TTL 0.43 6.27 0.33 1.13e-9 Response to antipsychotic treatment; CRC cis rs8141529 0.509 rs12628211 chr22:29239250 T/C cg15103426 chr22:29168792 CCDC117 0.52 6.92 0.36 2.39e-11 Lymphocyte counts; CRC cis rs13191362 0.935 rs34063386 chr6:163041271 T/C cg21926612 chr6:163149169 PACRG;PARK2 0.96 12.19 0.56 1.85e-28 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs7843479 0.601 rs878873 chr8:21834581 T/C cg16476235 chr8:21771668 DOK2 0.4 6.98 0.36 1.59e-11 Mean corpuscular volume; CRC cis rs7769051 1.000 rs9493444 chr6:133125320 C/G cg07930552 chr6:133119739 C6orf192 0.72 8.67 0.43 1.96e-16 Type 2 diabetes nephropathy; CRC cis rs6484504 0.512 rs7940020 chr11:31366453 T/G cg14844989 chr11:31128820 NA 0.35 6.18 0.32 1.87e-9 Red blood cell count; CRC cis rs10512697 0.649 rs34098513 chr5:3486403 G/C cg19473799 chr5:3511975 NA -0.83 -6.35 -0.33 7.32e-10 Immune response to smallpox vaccine (IL-6); CRC cis rs7773004 0.905 rs994379 chr6:26305407 C/G cg13736514 chr6:26305472 NA 0.37 6.26 0.33 1.19e-9 Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for body mass index;Waist circumference adjusted for BMI in non-smokers;Waist circumference adjusted for BMI (adjusted for smoking behaviour); CRC cis rs4713118 0.586 rs6905516 chr6:28086478 A/G cg25164649 chr6:28176230 NA 0.77 9.5 0.46 4.6e-19 Parkinson's disease; CRC cis rs17401966 0.838 rs1556917 chr1:10400990 G/T cg19773385 chr1:10388646 KIF1B -0.66 -10.51 -0.5 1.81e-22 Hepatocellular carcinoma; CRC cis rs11190604 1.000 rs1054399 chr10:102312565 C/T cg16342193 chr10:102329863 NA -0.36 -6.0 -0.31 5.28e-9 Palmitoleic acid (16:1n-7) levels; CRC cis rs57221529 0.766 rs12518859 chr5:587432 C/T cg14541582 chr5:601475 NA -0.37 -7.19 -0.37 4.49e-12 Lung disease severity in cystic fibrosis; CRC cis rs832540 0.902 rs194059 chr5:56197416 G/A cg24531977 chr5:56204891 C5orf35 -0.46 -6.94 -0.36 2.08e-11 Coronary artery disease; CRC cis rs9322193 0.923 rs12205092 chr6:150082511 G/T cg13206674 chr6:150067644 NUP43 0.67 9.45 0.46 6.71e-19 Lung cancer; CRC cis rs9733 0.596 rs7418501 chr1:150711896 A/T cg17724175 chr1:150552817 MCL1 0.55 8.78 0.44 9.17e-17 Tonsillectomy; CRC cis rs7659604 0.643 rs6839375 chr4:122663610 G/C cg19748678 chr4:122722346 EXOSC9 0.46 6.54 0.34 2.36e-10 Type 2 diabetes; CRC cis rs6951245 1.000 rs80212261 chr7:1114012 C/T cg18402987 chr7:1209562 NA 0.66 7.02 0.36 1.29e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs2836950 0.501 rs2836984 chr21:40700949 A/C cg11890956 chr21:40555474 PSMG1 -0.61 -8.93 -0.44 3.04e-17 Menarche (age at onset); CRC cis rs769267 1.000 rs3764567 chr19:19440066 C/T cg03709012 chr19:19516395 GATAD2A -0.67 -9.88 -0.48 2.57e-20 Tonsillectomy; CRC cis rs597539 0.652 rs646586 chr11:68681653 C/T cg04772025 chr11:68637568 NA -0.46 -7.17 -0.37 5.12e-12 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs6964587 1.000 rs2188155 chr7:91599825 A/C cg17063962 chr7:91808500 NA 0.8 14.25 0.62 3.19e-36 Breast cancer; CRC cis rs7647973 0.925 rs6446256 chr3:49224210 A/G cg07690219 chr3:49449608 TCTA;RHOA -0.52 -6.1 -0.32 2.9e-9 Menarche (age at onset); CRC trans rs9771228 0.870 rs215605 chr7:32336965 G/T cg02979224 chr7:93204462 CALCR 0.36 6.33 0.33 7.9e-10 Cognitive ability;Verbal-numerical reasoning; CRC cis rs2882667 0.690 rs288033 chr5:138214094 A/G cg09476006 chr5:138032270 NA 0.57 9.99 0.48 1.03e-20 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs854555 0.651 rs854546 chr7:94923764 A/C cg04155289 chr7:94953770 PON1 0.45 6.19 0.32 1.81e-9 Response to TNF antagonist treatment; CRC cis rs1129187 0.755 rs2274514 chr6:42934500 C/T cg27588902 chr6:42928151 GNMT -0.41 -7.6 -0.39 3.13e-13 Alzheimer's disease in APOE e4+ carriers; CRC cis rs1577917 0.916 rs12203358 chr6:86603224 C/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.53 -6.78 -0.35 5.41e-11 Response to antipsychotic treatment; CRC trans rs1814175 0.527 rs3974435 chr11:49619533 G/A cg15704280 chr7:45808275 SEPT13 -0.75 -10.19 -0.49 2.22e-21 Height; CRC cis rs17253792 0.822 rs78615025 chr14:56168012 G/A cg01858014 chr14:56050164 KTN1 -0.92 -7.31 -0.37 2e-12 Putamen volume; CRC cis rs1816752 0.776 rs7998843 chr13:25017285 T/C cg02811702 chr13:24901961 NA 0.47 6.5 0.34 2.96e-10 Obesity-related traits; CRC cis rs10782582 0.609 rs5745394 chr1:76311731 G/A cg03433033 chr1:76189801 ACADM -0.4 -5.82 -0.31 1.39e-8 Daytime sleep phenotypes; CRC cis rs364477 1.000 rs370435 chr9:954997 T/C cg13952963 chr9:998547 NA 0.51 6.57 0.34 1.95e-10 Major depressive disorder; CRC cis rs17601876 1.000 rs17601876 chr15:51553909 C/T cg19946085 chr15:51559439 CYP19A1 0.3 5.94 0.31 7.34e-9 Estrone/androstenedione ratio in resected early stage-receptor positive breast cancer; CRC cis rs290268 0.874 rs772407 chr9:93560850 A/C cg02608019 chr9:93564028 SYK 0.45 7.11 0.37 7.09e-12 Platelet count; CRC trans rs7757969 0.500 rs9387042 chr6:112155670 T/G cg08211895 chr2:48828358 STON1-GTF2A1L 0.31 6.1 0.32 3.05e-9 Schizophrenia; CRC cis rs1475911 1.000 rs2839466 chr21:43512324 A/G cg14562523 chr21:43528734 C21orf128;UMODL1 0.45 6.23 0.32 1.42e-9 IgG glycosylation; CRC cis rs7209700 0.777 rs8073827 chr17:45344662 G/T cg08085267 chr17:45401833 C17orf57 0.44 6.13 0.32 2.52e-9 IgG glycosylation; CRC trans rs2303319 0.504 rs56026147 chr2:162614089 T/C cg23919916 chr10:103825097 HPS6 -0.69 -6.01 -0.31 4.8e-9 Cognitive function; CRC cis rs208520 1.000 rs12193077 chr6:66989548 C/T cg07460842 chr6:66804631 NA 0.92 11.13 0.52 1.2e-24 Exhaled nitric oxide output; CRC cis rs7131987 0.650 rs7957339 chr12:29456495 T/C cg09582351 chr12:29534625 ERGIC2 -0.34 -7.33 -0.37 1.8e-12 QT interval; CRC cis rs2046867 0.862 rs2322611 chr3:72830087 T/G cg25664220 chr3:72788482 NA -0.45 -6.41 -0.33 5.12e-10 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; CRC trans rs9291683 0.632 rs10939669 chr4:10045827 A/G cg26043149 chr18:55253948 FECH 0.53 8.17 0.41 6.72e-15 Bone mineral density; CRC cis rs896854 0.654 rs896847 chr8:95972551 G/A cg13393036 chr8:95962371 TP53INP1 -0.54 -9.26 -0.45 2.63e-18 Type 2 diabetes; CRC cis rs356992 0.767 rs1896297 chr2:60738227 A/G cg08426369 chr2:60753602 BCL11A -0.47 -6.59 -0.34 1.7e-10 Educational attainment (years of education); CRC cis rs10752881 1.000 rs12753817 chr1:182970337 A/T ch.1.3577855R chr1:183094577 LAMC1 0.86 15.24 0.64 4.81e-40 Colorectal cancer; CRC cis rs9488822 0.676 rs13194714 chr6:116394819 T/A cg05304507 chr6:116381966 FRK 0.31 8.24 0.41 4.01e-15 Cholesterol, total;LDL cholesterol; CRC cis rs9322193 0.576 rs7452592 chr6:150196581 A/G cg07701084 chr6:150067640 NUP43 0.56 6.66 0.34 1.18e-10 Lung cancer; CRC cis rs9435341 0.930 rs2232015 chr1:107599258 A/T cg09367891 chr1:107599246 PRMT6 0.7 10.47 0.5 2.41e-22 Facial morphology (factor 21, depth of nasal alae); CRC cis rs3820068 0.532 rs6701009 chr1:15935614 T/C cg27534772 chr1:16042836 PLEKHM2 0.55 10.82 0.51 1.57e-23 Systolic blood pressure; CRC cis rs10504229 1.000 rs73609764 chr8:58192971 G/A cg02290350 chr8:58132656 NA -0.42 -5.96 -0.31 6.62e-9 Developmental language disorder (linguistic errors); CRC cis rs6952808 0.564 rs73038441 chr7:2139286 T/C cg02951883 chr7:2050386 MAD1L1 -0.67 -10.49 -0.5 2.16e-22 Bipolar disorder and schizophrenia; CRC cis rs2549003 1.000 rs9282763 chr5:131822133 T/C cg00255919 chr5:131827918 IRF1 0.59 11.92 0.55 1.77e-27 Asthma (sex interaction); CRC cis rs8180040 0.800 rs62248905 chr3:47274082 A/G cg10298567 chr3:47292165 KIF9 0.41 6.38 0.33 5.89e-10 Colorectal cancer; CRC cis rs7539542 0.600 rs9943282 chr1:202895140 C/T cg19681188 chr1:202830198 LOC148709 0.45 6.44 0.33 4.18e-10 Mean platelet volume; CRC cis rs2952156 1.000 rs1810132 chr17:37866005 C/T cg11212589 chr17:38028394 ZPBP2 0.35 5.92 0.31 8.11e-9 Asthma; CRC trans rs7615952 0.605 rs34865555 chr3:125304134 C/T cg02560186 chr11:3602584 NA -0.64 -6.03 -0.32 4.4e-9 Blood pressure (smoking interaction); CRC cis rs7552404 1.000 rs4949874 chr1:76161889 T/C cg03433033 chr1:76189801 ACADM 0.82 11.35 0.53 1.98e-25 Blood metabolite levels;Acylcarnitine levels; CRC cis rs9361491 0.621 rs12196457 chr6:79627743 A/T cg05283184 chr6:79620031 NA -0.44 -6.38 -0.33 5.85e-10 Intelligence (multi-trait analysis); CRC trans rs1728785 0.892 rs1617749 chr16:68580890 A/G cg04657470 chr2:198365150 HSPE1;HSPD1 0.77 9.05 0.45 1.23e-17 Ulcerative colitis; CRC cis rs561341 1.000 rs508192 chr17:30315147 C/T cg19193384 chr17:30244184 NA 0.62 7.01 0.36 1.38e-11 Hip circumference adjusted for BMI; CRC cis rs1799949 0.859 rs11657004 chr17:41442751 A/G cg05368731 chr17:41323189 NBR1 0.62 9.52 0.46 3.9e-19 Menopause (age at onset); CRC cis rs62229266 0.804 rs2835241 chr21:37411380 G/T cg12218747 chr21:37451666 NA 0.44 7.59 0.39 3.35e-13 Mitral valve prolapse; CRC cis rs13256369 1.000 rs13271966 chr8:8575472 T/C cg00074818 chr8:8560427 CLDN23 0.35 6.41 0.33 5.04e-10 Obesity-related traits; CRC cis rs3213545 0.659 rs2259693 chr12:121457995 G/A cg25281562 chr12:121454272 C12orf43 0.39 5.69 0.3 2.83e-8 Subjective well-being;Cardiovascular disease risk factors; CRC cis rs2075371 1.000 rs2544210 chr7:133971535 C/T cg02659138 chr7:134003124 SLC35B4 0.37 6.45 0.34 3.99e-10 Mean platelet volume; CRC cis rs1552244 0.572 rs6442154 chr3:10168785 A/G cg10729496 chr3:10149963 C3orf24 0.48 5.61 0.3 4.19e-8 Alzheimer's disease; CRC cis rs6712932 1.000 rs28521663 chr2:105846716 T/C cg27422857 chr2:105853526 NA -0.33 -6.14 -0.32 2.38e-9 Type 2 diabetes; CRC cis rs514406 0.547 rs377808 chr1:53190359 T/G cg25767906 chr1:53392781 SCP2 -0.4 -6.22 -0.32 1.5e-9 Monocyte count; CRC cis rs780096 0.546 rs4665976 chr2:27640325 A/G cg02592271 chr2:27665507 KRTCAP3 -0.26 -6.07 -0.32 3.59e-9 Total body bone mineral density; CRC cis rs4730250 0.707 rs257386 chr7:106807783 C/G cg02696742 chr7:106810147 HBP1 -0.65 -6.93 -0.36 2.28e-11 Osteoarthritis; CRC cis rs3772130 1.000 rs3772128 chr3:121345094 G/T cg20356878 chr3:121714668 ILDR1 0.49 7.64 0.39 2.33e-13 Cognitive performance; CRC cis rs977987 0.866 rs17696831 chr16:75493298 C/G cg03315344 chr16:75512273 CHST6 0.59 9.95 0.48 1.45e-20 Dupuytren's disease; CRC cis rs1448094 0.967 rs10863115 chr12:86332586 T/C cg02569458 chr12:86230093 RASSF9 0.38 6.44 0.33 4.13e-10 Major depressive disorder; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg22560197 chr1:70687124 SFRS11 0.37 6.11 0.32 2.82e-9 Liver disease severity in Alagille syndrome; CRC cis rs4713118 0.513 rs156738 chr6:28014025 G/C cg15845792 chr6:28175446 NA 0.77 11.37 0.53 1.74e-25 Parkinson's disease; CRC cis rs6582630 0.638 rs12831496 chr12:38552604 G/A cg26384229 chr12:38710491 ALG10B -0.52 -7.6 -0.39 3.1e-13 Drug-induced liver injury (flucloxacillin); CRC cis rs2976388 0.609 rs2717602 chr8:143805683 G/A cg12516270 chr8:143859308 LYNX1 0.42 7.35 0.38 1.61e-12 Urinary tract infection frequency; CRC cis rs4727027 0.866 rs1358062 chr7:148783743 T/C cg23583168 chr7:148888333 NA -0.87 -14.42 -0.62 7.04e-37 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC cis rs9814567 0.712 rs4245905 chr3:134328864 C/T cg06109529 chr3:134205091 CEP63;ANAPC13 -0.67 -9.58 -0.47 2.53e-19 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs2286885 1.000 rs1537989 chr9:129241824 C/T cg15282417 chr9:129245246 FAM125B 0.46 8.38 0.42 1.55e-15 Intraocular pressure; CRC cis rs5167 0.504 rs3760629 chr19:45458146 A/C cg13119609 chr19:45449297 APOC2 0.32 5.93 0.31 7.52e-9 Blood protein levels; CRC cis rs6762 0.719 rs28655651 chr11:837121 G/C cg03116740 chr11:841335 TSPAN4;POLR2L -0.42 -7.23 -0.37 3.49e-12 Mean platelet volume; CRC cis rs10876993 0.890 rs1678516 chr12:58047458 G/A cg15848620 chr12:58087721 OS9 -0.63 -8.74 -0.43 1.26e-16 Celiac disease or Rheumatoid arthritis; CRC cis rs262150 0.522 rs2527182 chr7:158813812 A/G cg19418458 chr7:158789849 NA -0.48 -8.39 -0.42 1.5e-15 Facial morphology (factor 20); CRC cis rs6952808 0.501 rs4721429 chr7:2171704 T/C cg21782813 chr7:2030301 MAD1L1 0.47 8.18 0.41 6.34e-15 Bipolar disorder and schizophrenia; CRC cis rs1395 0.744 rs11126931 chr2:27474306 C/T cg23587288 chr2:27483067 SLC30A3 -0.37 -6.29 -0.33 1.03e-9 Blood metabolite levels; CRC cis rs116095464 0.558 rs62344300 chr5:246336 A/G cg22857025 chr5:266934 NA -1.25 -16.72 -0.68 7.27e-46 Breast cancer; CRC cis rs1153858 1.000 rs7169587 chr15:45640379 A/G cg10760299 chr15:45669010 GATM 0.49 7.81 0.4 7.61e-14 Homoarginine levels; CRC cis rs11758351 0.866 rs75091077 chr6:26207546 A/C cg08260959 chr6:26240920 HIST1H4F -0.36 -5.86 -0.31 1.1e-8 Gout;Renal underexcretion gout; CRC cis rs727505 0.866 rs67132333 chr7:124719801 A/G cg23710748 chr7:124431027 NA -0.72 -12.33 -0.56 5.81e-29 Lewy body disease; CRC cis rs34172651 0.917 rs7202252 chr16:24741686 T/C cg06028605 chr16:24865363 SLC5A11 -0.45 -8.42 -0.42 1.2e-15 Intelligence (multi-trait analysis); CRC trans rs9291683 0.588 rs17246745 chr4:9994583 T/C cg26043149 chr18:55253948 FECH 0.51 7.91 0.4 3.98e-14 Bone mineral density; CRC cis rs4713118 0.513 rs149962 chr6:28015918 G/A cg21251018 chr6:28226885 NKAPL 0.48 7.36 0.38 1.47e-12 Parkinson's disease; CRC cis rs2228479 0.850 rs62054601 chr16:89811751 C/G cg06558623 chr16:89946397 TCF25 1.15 10.8 0.51 1.85e-23 Skin colour saturation; CRC cis rs2072499 0.966 rs6427304 chr1:156156789 A/G cg24450063 chr1:156163899 SLC25A44 1.15 27.09 0.83 8.96e-86 Testicular germ cell tumor; CRC cis rs911119 0.908 rs6048950 chr20:23603252 A/G cg16589663 chr20:23618590 CST3 0.45 6.32 0.33 8.44e-10 Chronic kidney disease; CRC cis rs9322193 0.962 rs9322218 chr6:150103319 A/G cg04369109 chr6:150039330 LATS1 -0.43 -6.01 -0.31 4.85e-9 Lung cancer; CRC cis rs514406 0.893 rs2897561 chr1:53388747 C/A cg08859206 chr1:53392774 SCP2 -0.48 -7.54 -0.38 4.72e-13 Monocyte count; CRC cis rs13191362 0.872 rs13213421 chr6:163203805 A/G cg06582575 chr6:163149167 PACRG;PARK2 0.86 11.03 0.52 2.71e-24 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs10504229 1.000 rs17217033 chr8:58180061 G/T cg22535103 chr8:58192502 C8orf71 -0.82 -12.27 -0.56 9.63e-29 Developmental language disorder (linguistic errors); CRC cis rs112158604 1 rs112158604 chr1:150696792 TCTTCTGCAG/T cg17724175 chr1:150552817 MCL1 -0.46 -7.28 -0.37 2.49e-12 Lymphocyte counts; CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg03523550 chr11:64001996 VEGFB 0.39 6.23 0.32 1.43e-9 Obesity-related traits; CRC cis rs9322193 0.923 rs9322196 chr6:149940781 T/G cg07701084 chr6:150067640 NUP43 0.52 7.62 0.39 2.76e-13 Lung cancer; CRC cis rs3018066 0.748 rs7340989 chr4:107148720 G/A cg01869342 chr4:106983673 TBCK 0.43 6.48 0.34 3.31e-10 Cancer; CRC trans rs2303319 0.504 rs62187611 chr2:162431946 A/G cg14875682 chr5:52083620 ITGA1;PELO -0.77 -6.19 -0.32 1.79e-9 Cognitive function; CRC cis rs9291683 0.526 rs6827785 chr4:10018205 C/T cg11266682 chr4:10021025 SLC2A9 0.54 11.09 0.52 1.76e-24 Bone mineral density; CRC trans rs3858526 0.883 rs1453429 chr11:5933478 C/T cg01505111 chr6:125621795 HDDC2 0.38 6.07 0.32 3.59e-9 DNA methylation (variation); CRC cis rs929354 0.772 rs1182438 chr7:157027438 G/A cg17757837 chr7:157058334 UBE3C -0.75 -13.04 -0.58 1.25e-31 Body mass index; CRC cis rs11625487 0.609 rs74063385 chr14:77966859 C/T cg20045696 chr14:77926864 AHSA1 -0.64 -6.08 -0.32 3.36e-9 Neutrophil percentage of white cells;Sum neutrophil eosinophil counts;Neutrophil count; CRC trans rs67073037 0.955 rs3924272 chr2:29167678 C/T cg13899017 chr1:159158444 CADM3 -0.37 -6.23 -0.32 1.39e-9 Breast cancer;Breast cancer (estrogen-receptor negative); CRC cis rs2415984 0.579 rs17740937 chr14:46959273 A/G cg14871534 chr14:47121158 RPL10L -0.44 -6.23 -0.32 1.43e-9 Number of children ever born; CRC cis rs13108904 0.967 rs2293635 chr4:1291791 A/G cg19318889 chr4:1322082 MAEA 0.41 5.73 0.3 2.28e-8 Obesity-related traits; CRC cis rs7224737 1.000 rs7224737 chr17:40289364 A/G cg00647820 chr17:40259828 DHX58 0.41 5.74 0.3 2.14e-8 Fibrinogen levels; CRC cis rs4363385 0.693 rs662506 chr1:153048386 A/C cg25856811 chr1:152973957 SPRR3 0.24 6.57 0.34 1.96e-10 Inflammatory skin disease; CRC cis rs8180040 0.767 rs11920853 chr3:47308183 G/A cg10298567 chr3:47292165 KIF9 0.42 6.56 0.34 2.07e-10 Colorectal cancer; CRC cis rs1904096 0.506 rs6841121 chr4:95222995 G/A cg11021082 chr4:95130006 SMARCAD1 -0.56 -9.02 -0.45 1.6e-17 Type 2 diabetes; CRC cis rs7618915 0.547 rs11709448 chr3:52647449 T/C cg07507251 chr3:52567010 NT5DC2 0.46 6.64 0.34 1.3e-10 Bipolar disorder; CRC trans rs800082 0.690 rs2717392 chr3:144280080 T/C cg24215973 chr2:240111563 HDAC4 0.57 8.89 0.44 4.06e-17 Smoking behavior; CRC cis rs1065656 0.553 rs344360 chr16:1839221 T/C cg03013636 chr16:1946785 NA -0.47 -5.85 -0.31 1.18e-8 Insulin-like growth factors; CRC cis rs6429082 0.509 rs35446932 chr1:235523480 C/T cg26050004 chr1:235667680 B3GALNT2 0.42 6.0 0.31 5.15e-9 Adiposity; CRC cis rs6951245 1.000 rs1881123 chr7:1084706 C/T cg21664854 chr7:1097933 C7orf50;GPR146 0.79 8.96 0.44 2.48e-17 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs9916302 0.904 rs7223438 chr17:37521355 T/C cg03013999 chr17:37608204 MED1 -0.46 -6.95 -0.36 1.97e-11 Glomerular filtration rate (creatinine); CRC cis rs780096 0.565 rs780104 chr2:27677691 G/A cg02592271 chr2:27665507 KRTCAP3 -0.28 -6.58 -0.34 1.83e-10 Total body bone mineral density; CRC cis rs9733 0.596 rs1136808 chr1:150702717 G/C cg15448220 chr1:150897856 SETDB1 0.45 6.41 0.33 5.09e-10 Tonsillectomy; CRC cis rs10242455 0.702 rs55927283 chr7:99057191 G/C cg18809830 chr7:99032528 PTCD1 -0.93 -7.32 -0.37 1.89e-12 Blood metabolite levels; CRC cis rs12188164 0.620 rs56070387 chr5:482531 A/T cg21972741 chr5:435613 AHRR 0.48 5.61 0.3 4.25e-8 Cystic fibrosis severity; CRC cis rs9768139 0.935 rs10949715 chr7:158117246 G/T cg24154853 chr7:158122151 PTPRN2 0.6 9.96 0.48 1.34e-20 Calcium levels; CRC cis rs9372498 0.536 rs1319987 chr6:118782236 A/G cg15382696 chr6:118971807 C6orf204 0.59 7.5 0.38 6.18e-13 Diastolic blood pressure; CRC cis rs8067545 1.000 rs8071730 chr17:19932731 C/T cg13482628 chr17:19912719 NA 0.54 8.68 0.43 1.81e-16 Schizophrenia; CRC cis rs7589728 0.563 rs79892776 chr2:88470593 G/A cg24977027 chr2:88469347 THNSL2 0.63 7.73 0.39 1.29e-13 Plasma clusterin levels; CRC cis rs2204008 0.840 rs3892363 chr12:38479487 G/A cg13010199 chr12:38710504 ALG10B 0.49 6.49 0.34 3.13e-10 Bladder cancer; CRC trans rs2228479 0.702 rs17233441 chr16:89817998 C/G cg24644049 chr4:85504048 CDS1 0.9 7.46 0.38 7.69e-13 Skin colour saturation; CRC cis rs2032447 0.702 rs199753 chr6:26001888 G/A cg03264133 chr6:25882463 NA -0.55 -7.49 -0.38 6.6e-13 Intelligence (multi-trait analysis); CRC cis rs939658 0.776 rs35382567 chr15:79440897 C/T cg17916960 chr15:79447300 NA -0.44 -7.1 -0.36 7.67e-12 Refractive error; CRC cis rs4862750 0.872 rs7672831 chr4:187898882 C/T cg03452623 chr4:187889614 NA -0.91 -22.06 -0.77 7.6e-67 Lobe attachment (rater-scored or self-reported); CRC cis rs6963495 0.818 rs73190166 chr7:105159955 G/A cg02135003 chr7:105160482 PUS7 -0.9 -12.2 -0.56 1.71e-28 Bipolar disorder (body mass index interaction); CRC cis rs2066819 1.000 rs57870697 chr12:56752874 A/G cg26714650 chr12:56694279 CS -1.4 -10.71 -0.51 3.55e-23 Psoriasis vulgaris; CRC cis rs7447593 0.626 rs3812036 chr5:176813404 C/T cg16006841 chr5:176797999 RGS14 0.68 10.27 0.49 1.24e-21 Urinary electrolytes (magnesium/calcium ratio); CRC cis rs9549328 0.700 rs4907570 chr13:113617651 T/C cg08614441 chr13:113633676 MCF2L 0.4 7.08 0.36 8.76e-12 Systolic blood pressure; CRC cis rs1997103 1.000 rs6954474 chr7:55404847 A/G cg17469321 chr7:55412551 NA 0.71 11.08 0.52 1.79e-24 QRS interval (sulfonylurea treatment interaction); CRC cis rs7107174 0.901 rs2450139 chr11:77924544 G/A cg02023728 chr11:77925099 USP35 0.45 7.45 0.38 8.36e-13 Testicular germ cell tumor; CRC trans rs7011507 1.000 rs13261342 chr8:49195847 C/A cg04544946 chr8:978226 NA 0.44 5.98 0.31 5.96e-9 Inflammatory bowel disease;Ulcerative colitis; CRC cis rs7927592 0.913 rs10896338 chr11:68299360 G/A cg16797656 chr11:68205561 LRP5 0.36 5.75 0.3 2.08e-8 Total body bone mineral density; CRC cis rs9649213 0.593 rs6969234 chr7:97987986 T/C cg00277769 chr7:97922759 BAIAP2L1 -0.6 -10.53 -0.5 1.59e-22 Prostate cancer (SNP x SNP interaction); CRC cis rs2398893 0.889 rs2039313 chr9:96781684 C/G cg14459158 chr9:96720562 NA -0.4 -6.59 -0.34 1.78e-10 Waist-hip ratio;Waist-to-hip ratio adjusted for body mass index; CRC cis rs4665809 0.878 rs4143538 chr2:26290178 A/C cg22920501 chr2:26401640 FAM59B -0.57 -7.37 -0.38 1.39e-12 Gut microbiome composition (summer); CRC cis rs11958404 0.932 rs6894528 chr5:157434788 A/G cg05962755 chr5:157440814 NA 1.01 12.88 0.58 5.12e-31 IgG glycosylation; CRC trans rs12517041 1.000 rs7734125 chr5:23300072 G/A ch.8.1293020R chr8:59333349 UBXN2B -0.56 -6.2 -0.32 1.74e-9 Calcium levels; CRC cis rs9311474 0.607 rs11711421 chr3:52561779 C/T cg18404041 chr3:52824283 ITIH1 -0.32 -6.49 -0.34 3.07e-10 Electroencephalogram traits; CRC cis rs2842992 0.789 rs2295901 chr6:160201295 C/A cg16489826 chr6:160211363 TCP1;MRPL18 0.49 6.24 0.33 1.37e-9 Age-related macular degeneration (geographic atrophy); CRC cis rs2762353 0.574 rs16890999 chr6:25755583 A/G cg15691649 chr6:25882328 NA 0.48 6.17 0.32 1.99e-9 Blood metabolite levels; CRC cis rs6961069 0.774 rs1054516 chr7:80284942 T/C cg04458919 chr7:80252533 CD36 0.35 6.06 0.32 3.65e-9 Platelet count; CRC trans rs7819412 0.668 rs920047 chr8:11087475 C/T cg16141378 chr3:129829833 LOC729375 0.4 6.13 0.32 2.58e-9 Triglycerides; CRC cis rs3617 0.573 rs2336668 chr3:52919096 G/T cg07507251 chr3:52567010 NT5DC2 -0.38 -5.76 -0.3 1.97e-8 Red blood cell count;Autism spectrum disorder or schizophrenia; CRC cis rs1059312 0.808 rs900982 chr12:129304369 G/A cg09035930 chr12:129282057 SLC15A4 0.49 8.05 0.41 1.54e-14 Systemic lupus erythematosus; CRC cis rs10504229 0.679 rs12679941 chr8:58051812 G/T cg02725872 chr8:58115012 NA -0.47 -7.44 -0.38 8.91e-13 Developmental language disorder (linguistic errors); CRC cis rs8005677 0.828 rs35085068 chr14:23409909 C/A cg25600027 chr14:23388339 RBM23 -0.42 -6.3 -0.33 9.66e-10 Cognitive ability (multi-trait analysis); CRC cis rs938554 0.513 rs3733588 chr4:9997303 A/G cg00071950 chr4:10020882 SLC2A9 -0.41 -6.32 -0.33 8.44e-10 Blood metabolite levels; CRC cis rs7811142 0.943 rs28660238 chr7:100023308 C/T cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.62 8.4 0.42 1.38e-15 Platelet count; CRC cis rs501120 0.810 rs510785 chr10:44749990 C/A cg09554077 chr10:44749378 NA 0.9 13.3 0.59 1.4e-32 Coronary artery disease;Coronary heart disease; CRC cis rs6543140 0.929 rs6742530 chr2:103082280 G/A cg09003973 chr2:102972529 NA 0.41 5.83 0.31 1.33e-8 Blood protein levels; CRC cis rs919433 1.000 rs919433 chr2:198166565 G/A cg03934865 chr2:198174659 NA -0.46 -7.81 -0.4 7.76e-14 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC cis rs2739330 0.760 rs5760095 chr22:24247293 A/G cg18538332 chr22:24372958 LOC391322 -0.71 -10.83 -0.51 1.35e-23 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs1863824 0.625 rs11202023 chr10:88165453 C/T cg07322936 chr10:88137208 NA -0.62 -8.67 -0.43 2.08e-16 Schizophrenia; CRC cis rs11628318 0.614 rs3825565 chr14:103060465 G/A cg23071808 chr14:103021642 NA -0.64 -7.19 -0.37 4.38e-12 Platelet count; CRC cis rs2952156 0.920 rs12150298 chr17:37834541 T/C cg07936489 chr17:37558343 FBXL20 -0.4 -5.8 -0.3 1.53e-8 Asthma; CRC cis rs9487051 0.802 rs9487039 chr6:109610163 A/T cg01475377 chr6:109611718 NA -0.49 -9.34 -0.46 1.52e-18 Reticulocyte fraction of red cells; CRC cis rs736408 0.562 rs13071584 chr3:52804487 T/C cg10802521 chr3:52805072 NEK4 -0.58 -8.99 -0.44 1.98e-17 Bipolar disorder; CRC cis rs5753618 0.539 rs8135344 chr22:31671932 G/T cg07713946 chr22:31675144 LIMK2 -0.4 -5.68 -0.3 2.98e-8 Colorectal cancer; CRC cis rs4713118 0.866 rs2179094 chr6:27741825 T/C cg06470822 chr6:28175283 NA 0.75 10.22 0.49 1.85e-21 Parkinson's disease; CRC cis rs11711311 1.000 rs16861312 chr3:113492402 G/T cg15478005 chr3:113465772 ATP6V1A;NAA50 0.44 6.13 0.32 2.48e-9 IgG glycosylation; CRC cis rs4453791 0.696 rs35330920 chr3:38956328 T/G cg02254461 chr3:39195904 CSRNP1 0.46 5.79 0.3 1.66e-8 Social communication problems; CRC cis rs10504229 0.728 rs72650856 chr8:58152695 C/T cg08219700 chr8:58056026 NA 0.45 5.74 0.3 2.11e-8 Developmental language disorder (linguistic errors); CRC trans rs561341 1.000 rs113115092 chr17:30284164 G/A cg27661571 chr11:113659931 NA -0.95 -11.08 -0.52 1.91e-24 Hip circumference adjusted for BMI; CRC cis rs3858526 0.959 rs4758219 chr11:5951846 G/C cg26762873 chr11:5879799 OR52E8 -0.4 -5.88 -0.31 1.01e-8 DNA methylation (variation); CRC cis rs1008375 0.966 rs7666888 chr4:17695722 C/T cg04450456 chr4:17643702 FAM184B 0.35 5.71 0.3 2.53e-8 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs6459788 0.720 rs11974772 chr7:157250645 G/A cg03453431 chr7:157225567 NA -0.56 -8.73 -0.43 1.32e-16 Epstein-Barr virus copy number in lymphoblastoid cell lines; CRC cis rs11581903 0.568 rs11205978 chr1:53076057 G/A cg19751897 chr1:52520827 TXNDC12;BTF3L4 0.71 5.65 0.3 3.42e-8 Joint mobility (Beighton score); CRC cis rs4594175 0.926 rs10498421 chr14:51586412 A/G cg23942311 chr14:51606299 NA -0.65 -10.79 -0.51 1.96e-23 Cancer; CRC cis rs9303401 0.659 rs7225896 chr17:56637337 T/C cg10487724 chr17:56770010 TEX14;RAD51C 0.78 9.14 0.45 6.68e-18 Cognitive test performance; CRC cis rs9547692 0.938 rs4520715 chr13:37459113 C/T cg01493522 chr13:37497338 NA -0.59 -7.96 -0.4 2.77e-14 Coronary artery disease; CRC cis rs10751667 0.560 rs7924794 chr11:962745 A/T ch.11.42038R chr11:967971 AP2A2 0.58 9.97 0.48 1.25e-20 Alzheimer's disease (late onset); CRC cis rs9649213 0.613 rs10953256 chr7:97951886 G/C cg08684580 chr7:98029266 BAIAP2L1 -0.31 -5.62 -0.3 4.03e-8 Prostate cancer (SNP x SNP interaction); CRC cis rs208520 0.874 rs208517 chr6:66947040 G/T cg07460842 chr6:66804631 NA -0.96 -12.4 -0.56 3.1e-29 Exhaled nitric oxide output; CRC trans rs2303319 0.504 rs62188960 chr2:162492578 A/C cg16721101 chr20:25176146 ENTPD6 -0.7 -6.09 -0.32 3.23e-9 Cognitive function; CRC cis rs11105298 0.891 rs10858890 chr12:89907166 A/G cg00757033 chr12:89920650 WDR51B 0.37 6.18 0.32 1.94e-9 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; CRC cis rs4819052 0.851 rs8130285 chr21:46671701 G/C cg19498844 chr21:46707878 POFUT2;LOC642852 0.72 10.53 0.5 1.53e-22 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs34172651 0.517 rs12920774 chr16:24830750 T/C cg02428538 chr16:24856791 SLC5A11 -0.58 -6.67 -0.35 1.1e-10 Intelligence (multi-trait analysis); CRC cis rs9733 0.596 rs72702523 chr1:150650425 G/T cg10589385 chr1:150898437 SETDB1 0.28 6.01 0.31 4.89e-9 Tonsillectomy; CRC cis rs9381040 0.655 rs7775972 chr6:41038116 A/C cg03644281 chr6:41068752 NFYA;LOC221442 -0.43 -6.04 -0.32 4.1e-9 Alzheimer's disease (late onset); CRC cis rs7617773 0.780 rs11710257 chr3:48373214 T/G cg11946769 chr3:48343235 NME6 0.74 9.91 0.48 2.03e-20 Coronary artery disease; CRC cis rs7124681 0.584 rs11039448 chr11:47918416 G/T cg20307385 chr11:47447363 PSMC3 -0.49 -7.18 -0.37 4.82e-12 Body mass index (joint analysis main effects and physical activity interaction);Body mass index;Body mass index in physically active individuals; CRC cis rs12971120 1.000 rs3829640 chr18:72174980 A/G cg25817165 chr18:72167213 CNDP2 -0.65 -9.65 -0.47 1.5e-19 Refractive error; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg12274314 chr17:62223237 SNORA76;SNORD104 0.47 6.52 0.34 2.7e-10 Response to antipsychotic treatment; CRC cis rs2227564 0.672 rs2459449 chr10:75669013 T/C cg00564723 chr10:75632066 CAMK2G -0.31 -7.22 -0.37 3.57e-12 Crohn's disease;Inflammatory bowel disease; CRC cis rs10782582 0.522 rs12125933 chr1:76130920 C/T cg10523679 chr1:76189770 ACADM -0.41 -5.76 -0.3 1.96e-8 Daytime sleep phenotypes; CRC cis rs453193 0.597 rs3111416 chr2:8452313 G/A cg12167548 chr2:8464763 NA 0.37 6.52 0.34 2.72e-10 Granulocyte percentage of myeloid white cells; CRC cis rs13191362 0.935 rs34603926 chr6:163266793 A/T cg21926612 chr6:163149169 PACRG;PARK2 0.7 8.97 0.44 2.35e-17 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs9467773 1.000 rs9467797 chr6:26568473 A/T cg09904177 chr6:26538194 HMGN4 0.86 14.82 0.63 2.06e-38 Intelligence (multi-trait analysis); CRC cis rs654950 1.000 rs679449 chr1:41988634 G/T cg06885757 chr1:42089581 HIVEP3 -0.44 -7.36 -0.38 1.52e-12 Airway imaging phenotypes; CRC cis rs995000 0.965 rs11207977 chr1:62977307 C/T cg19896129 chr1:63156450 NA 0.4 5.84 0.31 1.23e-8 Triglyceride levels; CRC cis rs2692947 0.702 rs6717101 chr2:96505552 C/T cg23100626 chr2:96804247 ASTL 0.27 7.07 0.36 9.2e-12 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; CRC cis rs4285028 0.948 rs34837785 chr3:121657776 G/A cg11130432 chr3:121712080 ILDR1 -0.46 -5.81 -0.3 1.49e-8 Multiple sclerosis; CRC cis rs6504950 0.830 rs12938118 chr17:53037359 T/C cg26251398 chr17:52985966 TOM1L1 0.42 5.62 0.3 4.01e-8 Breast cancer; CRC cis rs7072216 0.922 rs6584191 chr10:100152055 C/G cg26618903 chr10:100175079 PYROXD2 -0.39 -6.67 -0.35 1.09e-10 Metabolite levels; CRC cis rs972578 1.000 rs5759062 chr22:43363195 C/G cg01576275 chr22:43409880 NA -0.45 -7.27 -0.37 2.62e-12 Mean platelet volume; CRC cis rs344364 0.511 rs1742468 chr16:1950243 C/G cg14074117 chr16:1909714 C16orf73 0.41 5.66 0.3 3.28e-8 Glomerular filtration rate in chronic kidney disease; CRC cis rs9733 0.596 rs72702523 chr1:150650425 G/T cg18016565 chr1:150552671 MCL1 0.46 6.74 0.35 7.01e-11 Tonsillectomy; CRC cis rs4665809 0.627 rs7562192 chr2:26469457 C/G cg04944784 chr2:26401820 FAM59B 0.88 11.97 0.55 1.19e-27 Gut microbiome composition (summer); CRC cis rs9522267 0.535 rs9522301 chr13:112236726 A/T cg14352298 chr13:112236639 NA 0.3 6.77 0.35 5.79e-11 Hepatitis; CRC cis rs7553864 1.000 rs4626859 chr1:87614020 G/A cg02083836 chr1:87617350 LOC339524 0.35 6.24 0.33 1.36e-9 Smoking behavior; CRC cis rs58688157 0.705 rs936469 chr11:606749 G/A cg01842473 chr11:617407 IRF7;MUPCDH -0.54 -6.47 -0.34 3.46e-10 Systemic lupus erythematosus; CRC cis rs16870629 0.564 rs326050 chr5:1002620 C/T cg00278107 chr5:1061253 SLC12A7 0.67 9.63 0.47 1.66e-19 QT interval; CRC cis rs7474896 0.559 rs2738185 chr10:38247736 G/A cg25427524 chr10:38739819 LOC399744 0.59 7.25 0.37 3.04e-12 Obesity (extreme); CRC cis rs10771431 0.738 rs11049697 chr12:9385339 T/C cg08997352 chr12:9597637 DDX12 -0.53 -8.05 -0.41 1.49e-14 Breast size; CRC cis rs6701037 0.566 rs4344281 chr1:175135376 C/T cg00321850 chr1:175162397 KIAA0040 0.43 7.07 0.36 9.08e-12 Alcohol dependence; CRC cis rs919433 0.963 rs7582736 chr2:198170342 A/G cg03934865 chr2:198174659 NA -0.45 -7.12 -0.37 6.84e-12 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC cis rs34787248 1 rs34787248 chr6:28197886 C/T cg02683197 chr6:28174875 NA 0.64 6.59 0.34 1.77e-10 Autism spectrum disorder or schizophrenia; CRC cis rs7605827 0.930 rs2049719 chr2:15515058 A/G cg19274914 chr2:15703543 NA 0.38 5.78 0.3 1.78e-8 Educational attainment (years of education); CRC cis rs1712517 0.904 rs7905968 chr10:105135319 C/T cg05636881 chr10:105038444 INA 0.48 8.28 0.42 3.13e-15 Migraine; CRC cis rs7259376 0.623 rs58636168 chr19:22530129 C/A cg02657401 chr19:22469223 NA -0.3 -6.27 -0.33 1.14e-9 Menopause (age at onset); CRC cis rs4927850 0.881 rs7630489 chr3:195753401 T/C cg01181863 chr3:195395398 SDHAP2 -0.57 -8.0 -0.4 2.17e-14 Pancreatic cancer; CRC trans rs8002861 0.875 rs11616803 chr13:44457109 A/G cg12856521 chr11:46389249 DGKZ -0.43 -6.78 -0.35 5.74e-11 Leprosy; CRC trans rs9929218 0.551 rs7201437 chr16:68727130 A/C cg04657470 chr2:198365150 HSPE1;HSPD1 1.06 22.07 0.77 6.84e-67 Colorectal cancer; CRC cis rs2404602 0.598 rs11634019 chr15:76634680 A/G cg03037974 chr15:76606532 NA -0.46 -6.54 -0.34 2.33e-10 Blood metabolite levels; CRC cis rs7746199 0.736 rs6904596 chr6:27491299 G/A cg19041857 chr6:27730383 NA -0.75 -6.59 -0.34 1.79e-10 Gait speed in old age;Autism spectrum disorder or schizophrenia; CRC cis rs11785400 0.793 rs4301430 chr8:143737416 A/G cg24634471 chr8:143751801 JRK 0.47 6.21 0.32 1.56e-9 Schizophrenia; CRC cis rs7932354 0.583 rs10769210 chr11:46872227 G/A cg19486271 chr11:47235900 DDB2 -0.42 -6.55 -0.34 2.26e-10 Bone mineral density (hip);Bone mineral density; CRC cis rs9322193 0.923 rs55849538 chr6:149956466 T/C cg07701084 chr6:150067640 NUP43 0.56 7.92 0.4 3.58e-14 Lung cancer; CRC cis rs6500395 0.775 rs28481630 chr16:48663664 G/C cg04672837 chr16:48644449 N4BP1 0.44 6.53 0.34 2.53e-10 Response to tocilizumab in rheumatoid arthritis; CRC cis rs802075 0.967 rs635895 chr6:49658348 C/T cg20364632 chr6:49636226 NA -0.37 -5.97 -0.31 6.3e-9 Bone mineral density (hip) and age at menarche; CRC cis rs4319547 0.626 rs11057882 chr12:122875046 A/G cg23029597 chr12:123009494 RSRC2 -0.55 -6.7 -0.35 9.14e-11 Body mass index; CRC cis rs116095464 0.614 rs28736753 chr5:274081 G/A cg22857025 chr5:266934 NA -1.23 -16.46 -0.67 7.71e-45 Breast cancer; CRC cis rs4268898 0.896 rs2702042 chr2:24546542 C/T cg06627628 chr2:24431161 ITSN2 -0.57 -8.68 -0.43 1.88e-16 Asthma; CRC cis rs782590 0.902 rs4672052 chr2:55732018 A/C cg18811423 chr2:55921094 PNPT1 0.82 14.96 0.64 5.91e-39 Metabolic syndrome; CRC cis rs644799 0.710 rs11021309 chr11:95501898 C/A cg03916912 chr11:95522834 CEP57;FAM76B 0.86 15.71 0.65 6.72e-42 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs2014572 0.967 rs7248000 chr19:57762139 C/T cg24459738 chr19:57751996 ZNF805 -0.56 -8.87 -0.44 4.8e-17 Hyperactive-impulsive symptoms; CRC cis rs9467773 1.000 rs11756120 chr6:26529808 G/C cg09904177 chr6:26538194 HMGN4 0.86 14.9 0.63 9.92e-39 Intelligence (multi-trait analysis); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg15099410 chr1:28585832 SESN2 0.43 6.33 0.33 7.96e-10 Response to antipsychotic treatment; CRC cis rs9399135 0.935 rs6908681 chr6:135337733 A/G cg24558204 chr6:135376177 HBS1L 0.52 8.21 0.41 5.05e-15 Red blood cell count; CRC cis rs5750830 0.649 rs5757657 chr22:39798429 G/T cg11247378 chr22:39784982 NA -0.49 -9.82 -0.48 4.02e-20 Intelligence (multi-trait analysis); CRC cis rs3796352 1.000 rs13074524 chr3:52974184 A/G cg07884673 chr3:53033167 SFMBT1 0.65 5.71 0.3 2.51e-8 Immune reponse to smallpox (secreted IL-2); CRC cis rs9943753 0.525 rs7957928 chr12:109835975 C/G cg19025524 chr12:109796872 NA -0.51 -7.79 -0.39 8.61e-14 HDL cholesterol; CRC cis rs853679 0.824 rs1321505 chr6:28052823 A/C cg06470822 chr6:28175283 NA 0.83 6.79 0.35 5.23e-11 Depression; CRC cis rs950169 0.959 rs12911210 chr15:84792083 A/C cg24253500 chr15:84953950 NA 0.38 6.43 0.33 4.55e-10 Schizophrenia; CRC cis rs4727027 0.704 rs12535154 chr7:148895304 G/A cg23583168 chr7:148888333 NA -0.94 -17.95 -0.7 1.03e-50 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC cis rs1552244 1.000 rs12152515 chr3:10143976 C/T cg13047869 chr3:10149882 C3orf24 0.5 7.15 0.37 5.6e-12 Alzheimer's disease; CRC cis rs853679 0.517 rs9380057 chr6:28104634 G/T cg12273811 chr6:28175739 NA 0.73 9.36 0.46 1.34e-18 Depression; CRC trans rs2303319 0.504 rs1006428 chr2:162592559 A/C cg04551154 chr10:95462393 C10orf4 -0.75 -6.37 -0.33 6.43e-10 Cognitive function; CRC cis rs10752881 1.000 rs6424880 chr1:182986679 C/T ch.1.3577855R chr1:183094577 LAMC1 0.86 15.22 0.64 5.91e-40 Colorectal cancer; CRC cis rs259282 0.851 rs174083 chr19:33141180 A/G cg08127369 chr19:33164662 ANKRD27 0.37 5.86 0.31 1.1e-8 Schizophrenia; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg08838784 chr17:16557147 ZNF624 0.37 5.96 0.31 6.49e-9 Liver disease severity in Alagille syndrome; CRC trans rs2303319 0.504 rs16846073 chr2:162586548 C/G cg25193742 chr10:104614220 C10orf32 -0.72 -6.15 -0.32 2.29e-9 Cognitive function; CRC cis rs2180341 0.883 rs6904630 chr6:127696869 A/G cg24812749 chr6:127587940 RNF146 0.97 13.51 0.6 2.11e-33 Breast cancer; CRC cis rs12048904 0.541 rs1571046 chr1:101299216 T/C cg00063077 chr1:101360652 SLC30A7;EXTL2 0.72 10.46 0.5 2.74e-22 Multiple sclerosis; CRC cis rs6809651 0.524 rs6444105 chr3:185811301 C/T cg00760338 chr3:185826511 ETV5 -0.74 -9.4 -0.46 9.65e-19 Body mass index in physically active individuals;Glomerular filtration rate (creatinine);Body mass index (joint analysis main effects and physical activity interaction);Body mass index;Body mass index in physically inactive individuals; CRC cis rs873917 0.577 rs784612 chr1:40122939 T/C cg06209491 chr1:40138402 NT5C1A -0.49 -7.34 -0.38 1.63e-12 Amyotrophic lateral sclerosis; CRC cis rs10242455 0.702 rs10251282 chr7:98990236 T/C cg18809830 chr7:99032528 PTCD1 -1.11 -7.93 -0.4 3.46e-14 Blood metabolite levels; CRC cis rs5769707 0.656 rs135878 chr22:50014369 T/A cg20744362 chr22:50050164 C22orf34 0.34 6.03 0.32 4.37e-9 Monocyte count;Monocyte percentage of white cells; CRC cis rs123509 0.731 rs73087348 chr3:42811571 C/T cg12982090 chr3:42733453 KBTBD5 -0.56 -6.8 -0.35 4.85e-11 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs780096 0.546 rs715326 chr2:27725761 A/G cg22903471 chr2:27725779 GCKR 0.36 5.95 0.31 6.88e-9 Total body bone mineral density; CRC cis rs28386778 0.897 rs8073515 chr17:61795328 A/C cg11494091 chr17:61959527 GH2 0.59 9.97 0.48 1.25e-20 Prudent dietary pattern; CRC cis rs9322193 0.923 rs12660304 chr6:150060783 A/G cg07701084 chr6:150067640 NUP43 0.6 9.1 0.45 8.65e-18 Lung cancer; CRC cis rs7131987 0.621 rs3782506 chr12:29445422 A/C cg09582351 chr12:29534625 ERGIC2 0.34 7.32 0.37 1.93e-12 QT interval; CRC cis rs478304 0.651 rs11604451 chr11:65551710 C/T cg27068330 chr11:65405492 SIPA1 -0.6 -8.85 -0.44 5.48e-17 Acne (severe); CRC cis rs7615952 0.576 rs4646759 chr3:125822946 G/C cg15145296 chr3:125709740 NA -0.57 -6.72 -0.35 8.25e-11 Blood pressure (smoking interaction); CRC cis rs4234798 1.000 rs4689653 chr4:7223319 T/G cg18431297 chr4:7219810 SORCS2 0.63 11.33 0.53 2.41e-25 Insulin-like growth factors; CRC cis rs11098499 0.909 rs28668716 chr4:120309875 T/C cg24375607 chr4:120327624 NA 0.51 7.81 0.4 7.91e-14 Corneal astigmatism; CRC cis rs73206853 0.764 rs56127909 chr12:110833763 G/A cg12870014 chr12:110450643 ANKRD13A 0.78 8.56 0.43 4.41e-16 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC cis rs1401999 0.864 rs4148563 chr3:183725999 T/C cg05044414 chr3:183734942 ABCC5 0.43 7.37 0.38 1.35e-12 Anterior chamber depth; CRC cis rs8177253 1.000 rs1358023 chr3:133484393 T/C cg01448562 chr3:133502909 NA -0.54 -9.24 -0.45 3.04e-18 Iron status biomarkers; CRC cis rs17125944 0.686 rs4450307 chr14:53334783 G/A cg00686598 chr14:53173677 PSMC6 -0.6 -5.66 -0.3 3.22e-8 Alzheimer's disease (late onset); CRC cis rs10504229 0.953 rs6991035 chr8:58183374 C/T cg02725872 chr8:58115012 NA -0.38 -6.43 -0.33 4.44e-10 Developmental language disorder (linguistic errors); CRC cis rs34779708 0.966 rs11599606 chr10:35406626 G/A cg03585969 chr10:35415529 CREM 0.66 8.64 0.43 2.54e-16 Inflammatory bowel disease;Crohn's disease; CRC cis rs1403694 0.695 rs11919484 chr3:186432839 G/T cg04611788 chr3:186434169 KNG1 -0.6 -8.83 -0.44 6.23e-17 Blood protein levels; CRC cis rs6502050 0.842 rs7218075 chr17:80076808 C/G cg25804541 chr17:80189381 SLC16A3 0.32 6.13 0.32 2.51e-9 Life satisfaction; CRC cis rs7731657 0.537 rs10478953 chr5:130185380 A/C cg08523029 chr5:130500466 HINT1 0.46 6.17 0.32 1.95e-9 Fasting plasma glucose; CRC cis rs2153535 0.580 rs9393023 chr6:8469994 T/G cg07606381 chr6:8435919 SLC35B3 0.67 10.7 0.51 4.01e-23 Motion sickness; CRC cis rs2275731 0.625 rs7904333 chr10:16476271 C/T cg04254609 chr10:16479192 PTER -0.47 -6.83 -0.35 4.06e-11 Bone fracture in osteoporosis; CRC cis rs6582630 0.519 rs7294300 chr12:38277359 C/A cg13010199 chr12:38710504 ALG10B 0.45 5.75 0.3 2.07e-8 Drug-induced liver injury (flucloxacillin); CRC cis rs2576037 0.899 rs7233515 chr18:44585955 A/G cg19077165 chr18:44547161 KATNAL2 -0.5 -7.64 -0.39 2.47e-13 Personality dimensions; CRC cis rs4862750 0.914 rs6814259 chr4:187872337 T/C cg27532560 chr4:187881888 NA -0.56 -10.2 -0.49 2.05e-21 Lobe attachment (rater-scored or self-reported); CRC cis rs921968 0.541 rs532425 chr2:219434194 A/G cg02176678 chr2:219576539 TTLL4 0.54 8.61 0.43 3.16e-16 Mean corpuscular hemoglobin concentration; CRC cis rs7586879 0.638 rs10203482 chr2:25136916 T/C cg22495460 chr2:25135724 ADCY3 -0.88 -16.58 -0.67 2.68e-45 Body mass index; CRC cis rs12597458 0.752 rs8051239 chr16:72036257 T/A cg23815491 chr16:72088622 HP -0.5 -7.92 -0.4 3.77e-14 Prostate cancer; CRC cis rs7584330 0.666 rs72620816 chr2:238353604 C/T cg16989719 chr2:238392110 NA -0.4 -6.45 -0.34 3.92e-10 Prostate cancer; CRC cis rs4731207 0.596 rs1481339 chr7:124708237 A/G cg23710748 chr7:124431027 NA -0.4 -6.28 -0.33 1.07e-9 Cutaneous malignant melanoma; CRC cis rs2976388 0.590 rs11785290 chr8:143814849 A/G cg24046110 chr8:143859143 LYNX1 -0.44 -7.09 -0.36 8.09e-12 Urinary tract infection frequency; CRC cis rs11122272 0.735 rs2250719 chr1:231486208 G/A cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.52 -7.77 -0.39 1.03e-13 Hemoglobin concentration; CRC cis rs28386778 0.687 rs59596917 chr17:61806264 T/A cg25654072 chr17:61904446 PSMC5;FTSJ3 0.72 11.05 0.52 2.36e-24 Prudent dietary pattern; CRC cis rs35110281 0.774 rs2838327 chr21:45018566 A/C cg04455712 chr21:45112962 RRP1B 0.4 7.58 0.39 3.45e-13 Mean corpuscular volume; CRC cis rs2439831 0.850 rs28476182 chr15:44139643 C/T cg15269541 chr15:43626905 ADAL -0.49 -5.9 -0.31 9.27e-9 Lung cancer in ever smokers; CRC cis rs4665809 1.000 rs1550381 chr2:26266946 A/G cg04944784 chr2:26401820 FAM59B -0.6 -7.72 -0.39 1.38e-13 Gut microbiome composition (summer); CRC cis rs1129187 0.755 rs3293 chr6:42938377 G/T cg27588902 chr6:42928151 GNMT -0.41 -7.58 -0.39 3.59e-13 Alzheimer's disease in APOE e4+ carriers; CRC cis rs10992471 0.627 rs10820980 chr9:95253342 C/T cg14631576 chr9:95140430 CENPP -0.39 -6.78 -0.35 5.43e-11 Visceral adipose tissue/subcutaneous adipose tissue ratio; CRC cis rs9467711 0.538 rs9467632 chr6:25889706 A/G cg19084075 chr6:26124329 HIST1H2AC;HIST1H2BC 0.74 5.73 0.3 2.27e-8 Autism spectrum disorder or schizophrenia; CRC trans rs11039798 0.844 rs7126949 chr11:48972166 A/G cg03929089 chr4:120376271 NA 0.64 6.1 0.32 2.95e-9 Axial length; CRC cis rs9308731 0.644 rs3789065 chr2:111915022 C/G cg04202892 chr2:111875749 ACOXL 0.47 7.7 0.39 1.61e-13 Chronic lymphocytic leukemia; CRC cis rs3806843 0.676 rs2245643 chr5:140029780 C/T cg19875535 chr5:140030758 IK -0.67 -11.57 -0.54 3.37e-26 Depressive symptoms (multi-trait analysis); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg19958009 chr14:50087420 RPL36AL;MGAT2 0.4 6.56 0.34 2.05e-10 Liver disease severity in Alagille syndrome; CRC trans rs561341 0.769 rs12941700 chr17:30185022 A/G cg20587970 chr11:113659929 NA 1.06 12.66 0.57 3.45e-30 Hip circumference adjusted for BMI; CRC cis rs863345 0.604 rs949398 chr1:158461983 A/G cg12129480 chr1:158549410 OR10X1 -0.29 -6.04 -0.32 4.2e-9 Pneumococcal bacteremia; CRC trans rs9929218 0.954 rs9929479 chr16:68821271 G/C cg04657470 chr2:198365150 HSPE1;HSPD1 -0.81 -11.42 -0.53 1.17e-25 Colorectal cancer; CRC trans rs637571 0.522 rs7105628 chr11:65763067 C/T cg17712092 chr4:129076599 LARP1B 0.76 12.81 0.58 9.45e-31 Eosinophil percentage of white cells; CRC cis rs72615157 0.606 rs941288 chr7:99776808 G/A cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.54 6.21 0.32 1.63e-9 Lung function (FEV1/FVC); CRC cis rs10504229 0.728 rs17804822 chr8:58156276 T/C cg05313129 chr8:58192883 C8orf71 -0.48 -6.25 -0.33 1.26e-9 Developmental language disorder (linguistic errors); CRC cis rs782590 0.837 rs782584 chr2:55921116 C/G cg18811423 chr2:55921094 PNPT1 -0.9 -17.71 -0.7 9.21e-50 Metabolic syndrome; CRC cis rs34779708 0.931 rs34954932 chr10:35410807 G/T cg03585969 chr10:35415529 CREM 0.55 7.38 0.38 1.28e-12 Inflammatory bowel disease;Crohn's disease; CRC cis rs2228479 0.702 rs17233441 chr16:89817998 C/G cg19635926 chr16:89946313 TCF25 0.66 5.97 0.31 6.1e-9 Skin colour saturation; CRC cis rs2274273 0.837 rs7148171 chr14:55770744 G/C cg23234261 chr14:55582407 NA -0.29 -5.84 -0.31 1.25e-8 Protein biomarker; CRC cis rs883565 0.569 rs784489 chr3:39173426 T/C cg01426195 chr3:39028469 NA 0.42 6.97 0.36 1.71e-11 Handedness; CRC cis rs694739 0.628 rs617051 chr11:64133638 C/A cg23796481 chr11:64053134 BAD;GPR137 0.48 6.68 0.35 9.99e-11 Alopecia areata;Crohn's disease;Psoriasis vulgaris; CRC cis rs801193 0.660 rs2659897 chr7:66187715 A/G cg18876405 chr7:65276391 NA -0.51 -8.55 -0.43 4.73e-16 Aortic root size; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg09766769 chr16:4852830 ROGDI 0.44 6.13 0.32 2.48e-9 Anxiety disorder; CRC cis rs6952808 0.693 rs10950413 chr7:1912988 A/G cg00106254 chr7:1943704 MAD1L1 -0.42 -6.66 -0.34 1.17e-10 Bipolar disorder and schizophrenia; CRC cis rs6921919 0.638 rs6456815 chr6:28306137 C/A cg03623178 chr6:28175578 NA 0.45 6.0 0.31 5.12e-9 Autism spectrum disorder or schizophrenia; CRC cis rs9457247 1.000 rs1819333 chr6:167373547 G/T cg23791538 chr6:167370224 RNASET2 -0.39 -6.14 -0.32 2.43e-9 Crohn's disease; CRC cis rs7811142 0.830 rs3087502 chr7:99955364 G/A cg00814883 chr7:100076585 TSC22D4 -0.7 -8.85 -0.44 5.49e-17 Platelet count; CRC cis rs6952808 0.825 rs34296663 chr7:1935245 C/T cg02951883 chr7:2050386 MAD1L1 -0.69 -11.1 -0.52 1.56e-24 Bipolar disorder and schizophrenia; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg09930748 chr19:36359327 APLP1 -0.41 -6.3 -0.33 9.74e-10 Myopia (pathological); CRC cis rs10504229 0.679 rs17800895 chr8:58050085 A/G cg11062466 chr8:58055876 NA 0.55 6.98 0.36 1.67e-11 Developmental language disorder (linguistic errors); CRC trans rs4834770 0.717 rs1022146 chr4:120236103 A/G cg25214090 chr10:38739885 LOC399744 0.39 6.13 0.32 2.45e-9 Blood protein levels; CRC cis rs9926296 0.712 rs447735 chr16:89734349 T/C cg03605463 chr16:89740564 NA 0.62 9.55 0.47 3.18e-19 Vitiligo; CRC trans rs7615952 0.546 rs2976733 chr3:125414138 T/C cg07211511 chr3:129823064 LOC729375 -0.61 -8.58 -0.43 3.7e-16 Blood pressure (smoking interaction); CRC cis rs7772486 0.790 rs9376968 chr6:146180364 T/C cg13319975 chr6:146136371 FBXO30 -0.41 -6.2 -0.32 1.73e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs9858542 1.000 rs9812791 chr3:49682311 G/A cg03060546 chr3:49711283 APEH -0.5 -6.78 -0.35 5.72e-11 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs11748023 0.605 rs185123 chr5:139517197 T/C cg26211634 chr5:139558579 C5orf32 0.36 6.29 0.33 1.01e-9 Intelligence (multi-trait analysis); CRC trans rs2055729 0.645 rs62489486 chr8:9741925 G/A cg06636001 chr8:8085503 FLJ10661 0.57 7.0 0.36 1.45e-11 Multiple myeloma (hyperdiploidy); CRC cis rs10847980 0.590 rs1696326 chr12:123311981 A/G cg22842854 chr12:123319900 HIP1R -0.73 -5.74 -0.3 2.1e-8 Adiponectin levels; CRC cis rs12286929 0.669 rs11606837 chr11:115042837 C/T cg04055981 chr11:115044050 NA 0.44 7.06 0.36 1.02e-11 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs10752881 1.000 rs4233193 chr1:182970865 C/T ch.1.3577855R chr1:183094577 LAMC1 0.86 14.93 0.64 7.65e-39 Colorectal cancer; CRC cis rs6694672 0.867 rs4244141 chr1:197143618 G/A cg13682187 chr1:196946512 CFHR5 0.52 7.85 0.4 5.91e-14 Asthma; CRC cis rs2115630 1.000 rs55646601 chr15:85323568 G/T cg12501888 chr15:85177176 SCAND2 -0.36 -5.85 -0.31 1.18e-8 P wave terminal force; CRC cis rs10504229 0.516 rs60398072 chr8:58086559 G/A cg08219700 chr8:58056026 NA 0.53 8.92 0.44 3.31e-17 Developmental language disorder (linguistic errors); CRC cis rs589448 0.900 rs588493 chr12:69751986 G/A cg14784868 chr12:69753453 YEATS4 0.91 17.35 0.69 2.44e-48 Cerebrospinal fluid biomarker levels; CRC cis rs887829 0.570 rs6753320 chr2:234595615 G/T cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 0.45 7.03 0.36 1.19e-11 Metabolic traits;Bilirubin levels;Cholelithiasis-related traits in sickle cell anemia;Metabolite levels;Total bilirubin levels in HIV-1 infection;Serum metabolite levels;Blood metabolite levels; CRC cis rs735539 1.000 rs735539 chr13:21280034 A/G cg27499820 chr13:21296301 IL17D -0.37 -5.82 -0.31 1.37e-8 Dental caries; CRC cis rs881375 0.967 rs10739580 chr9:123695282 C/T cg14255062 chr9:123606675 PSMD5;LOC253039 0.4 5.87 0.31 1.05e-8 Rheumatoid arthritis; CRC cis rs1059312 1.000 rs2291350 chr12:129283711 G/A cg21616243 chr12:129299702 MGC16384;SLC15A4 -0.67 -11.13 -0.52 1.22e-24 Systemic lupus erythematosus; CRC cis rs7044106 0.791 rs7043969 chr9:123493989 A/C cg09586646 chr9:123605570 PSMD5;LOC253039 0.69 10.34 0.5 6.91e-22 Hip circumference adjusted for BMI; CRC cis rs7618915 0.547 rs62255362 chr3:52699741 C/G cg10802521 chr3:52805072 NEK4 -0.59 -9.02 -0.45 1.55e-17 Bipolar disorder; CRC cis rs910316 1.000 rs4322591 chr14:75600697 C/T cg03030879 chr14:75389066 RPS6KL1 -0.47 -7.45 -0.38 8.37e-13 Height; CRC cis rs992157 0.835 rs6729058 chr2:219148369 G/A cg04880052 chr2:219191631 PNKD -0.44 -6.93 -0.36 2.29e-11 Colorectal cancer; CRC cis rs1799949 1.000 rs8176120 chr17:41261233 C/T cg25072359 chr17:41440525 NA 0.46 7.02 0.36 1.29e-11 Menopause (age at onset); CRC cis rs2992756 0.663 rs1360915 chr1:18801804 T/C cg14356550 chr1:18808102 KLHDC7A -0.4 -5.69 -0.3 2.74e-8 Breast cancer; CRC cis rs2153535 0.601 rs2327091 chr6:8540369 G/A cg07606381 chr6:8435919 SLC35B3 0.69 11.29 0.53 3.23e-25 Motion sickness; CRC cis rs13108904 0.901 rs1316394 chr4:1315820 G/A cg19318889 chr4:1322082 MAEA 0.41 5.93 0.31 7.58e-9 Obesity-related traits; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg02625641 chr15:59041175 ADAM10 0.48 6.03 0.32 4.37e-9 Thyroid stimulating hormone; CRC cis rs7727544 0.735 rs272867 chr5:131681057 G/A cg07395648 chr5:131743802 NA -0.42 -6.57 -0.34 1.95e-10 Blood metabolite levels; CRC cis rs17331151 0.573 rs2276818 chr3:52864635 A/G cg06204229 chr3:52865917 ITIH4 0.58 7.94 0.4 3.2e-14 Immune reponse to smallpox (secreted IL-2); CRC cis rs853679 0.550 rs1233704 chr6:28166923 A/G cg15845792 chr6:28175446 NA -1.01 -15.68 -0.65 9.08e-42 Depression; CRC trans rs7944735 0.786 rs7123436 chr11:48013484 G/A cg15704280 chr7:45808275 SEPT13 0.56 6.2 0.32 1.73e-9 Intraocular pressure; CRC cis rs17376456 0.877 rs35747258 chr5:93310129 C/T cg09848695 chr5:92956644 FAM172A;MIR2277 0.63 5.67 0.3 3.18e-8 Diabetic retinopathy; CRC cis rs10927875 0.722 rs945425 chr1:16348412 T/C cg10494257 chr1:16342123 HSPB7 0.44 5.8 0.3 1.56e-8 Dilated cardiomyopathy; CRC cis rs6952808 0.608 rs6461049 chr7:2017445 C/T cg02951883 chr7:2050386 MAD1L1 0.61 10.18 0.49 2.39e-21 Bipolar disorder and schizophrenia; CRC cis rs11585357 0.843 rs72646796 chr1:17612503 T/C cg08277548 chr1:17600880 PADI3 -0.89 -11.32 -0.53 2.66e-25 Hair shape; CRC cis rs875971 0.862 rs6460293 chr7:65810192 C/A cg18876405 chr7:65276391 NA -0.53 -8.59 -0.43 3.58e-16 Aortic root size; CRC cis rs2243480 0.706 rs34466769 chr7:65453292 A/C cg18252515 chr7:66147081 NA -0.88 -10.69 -0.51 4.19e-23 Diabetic kidney disease; CRC cis rs7927771 1.000 rs12419692 chr11:47624714 A/C cg18512352 chr11:47633146 NA 0.48 9.65 0.47 1.46e-19 Subjective well-being; CRC cis rs1552244 1.000 rs4269070 chr3:10126083 C/G cg13047869 chr3:10149882 C3orf24 0.54 7.53 0.38 4.82e-13 Alzheimer's disease; CRC cis rs7072216 0.615 rs6584195 chr10:100160747 G/A cg26618903 chr10:100175079 PYROXD2 -0.35 -5.69 -0.3 2.86e-8 Metabolite levels; CRC cis rs875971 0.862 rs778697 chr7:65870426 G/A cg11764359 chr7:65958608 NA 0.57 8.44 0.42 1.01e-15 Aortic root size; CRC cis rs2836974 0.897 rs35064900 chr21:40555492 A/G cg06238570 chr21:40685208 BRWD1 0.74 10.35 0.5 6.5600000000000005e-22 Cognitive function; CRC cis rs317865 0.737 rs73234648 chr4:16193602 T/C cg04764131 chr4:16228633 TAPT1;FLJ39653 0.63 5.71 0.3 2.58e-8 Kidney disease (early stage) in type 1 diabetes; CRC cis rs896854 0.714 rs572547 chr8:95966286 A/G cg13393036 chr8:95962371 TP53INP1 0.45 6.73 0.35 7.51e-11 Type 2 diabetes; CRC cis rs932287 0.505 rs2742536 chr11:8909816 G/C cg00186954 chr11:8933980 ST5;C11orf17 -0.5 -8.59 -0.43 3.44e-16 Colonoscopy-negative controls vs population controls; CRC cis rs4713118 0.513 rs1225591 chr6:28148752 G/A cg20615401 chr6:28092323 ZSCAN16 0.44 5.76 0.3 1.88e-8 Parkinson's disease; CRC trans rs1814175 0.645 rs11040535 chr11:49808669 C/T cg15704280 chr7:45808275 SEPT13 -0.94 -16.27 -0.67 4.47e-44 Height; CRC cis rs35883536 1.000 rs6681906 chr1:101086414 C/T cg14515779 chr1:101123966 NA -0.45 -8.65 -0.43 2.25e-16 Monocyte count; CRC cis rs4713118 0.513 rs149942 chr6:28001610 T/C cg15845792 chr6:28175446 NA 0.73 10.85 0.51 1.19e-23 Parkinson's disease; CRC cis rs875971 0.522 rs10807697 chr7:65416170 A/G cg05627663 chr7:65219948 SNORA22;CCT6P1 0.47 6.94 0.36 2.08e-11 Aortic root size; CRC cis rs10504229 0.683 rs7459958 chr8:58111905 G/T cg02725872 chr8:58115012 NA -0.66 -11.64 -0.54 1.83e-26 Developmental language disorder (linguistic errors); CRC cis rs600626 0.588 rs10899116 chr11:75476195 C/T cg24262691 chr11:75473276 NA 0.51 6.97 0.36 1.74e-11 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CRC cis rs372883 0.506 rs2832301 chr21:30749712 G/A cg08807101 chr21:30365312 RNF160 0.48 7.2 0.37 4.15e-12 Pancreatic cancer; CRC cis rs933688 0.938 rs12110065 chr5:90718474 A/G cg26981201 chr5:90679533 LOC100129716;ARRDC3 1.03 16.09 0.66 2.15e-43 Smoking behavior; CRC cis rs951366 0.789 rs823137 chr1:205738302 C/T cg14159672 chr1:205819179 PM20D1 0.72 10.63 0.51 6.78e-23 Menarche (age at onset); CRC cis rs394563 0.967 rs444784 chr6:149798366 C/G cg16235748 chr6:149772707 ZC3H12D -0.37 -6.46 -0.34 3.71e-10 Dupuytren's disease; CRC trans rs34421088 0.560 rs2248315 chr8:11397086 T/A cg16141378 chr3:129829833 LOC729375 0.46 6.84 0.35 3.85e-11 Neuroticism; CRC cis rs113835537 0.877 rs3867132 chr11:66309269 C/T cg22134325 chr11:66188745 NPAS4 0.38 6.12 0.32 2.63e-9 Airway imaging phenotypes; CRC cis rs10870270 1.000 rs6560694 chr10:133773448 G/A cg17892150 chr10:133769511 PPP2R2D -0.74 -10.94 -0.52 5.78e-24 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; CRC cis rs9325144 0.647 rs11168819 chr12:39011082 C/A cg26384229 chr12:38710491 ALG10B -0.52 -7.39 -0.38 1.25e-12 Morning vs. evening chronotype; CRC cis rs7781266 0.842 rs1862871 chr7:133215165 A/C cg03336402 chr7:133662267 EXOC4 -0.55 -6.3 -0.33 9.81e-10 Educational attainment (college completion); CRC cis rs801193 1.000 rs7782320 chr7:66177098 C/T cg05627663 chr7:65219948 SNORA22;CCT6P1 0.41 6.01 0.31 4.8e-9 Aortic root size; CRC cis rs58688157 0.924 rs35865896 chr11:584591 A/G cg16486109 chr11:613632 IRF7 0.65 11.83 0.55 3.72e-27 Systemic lupus erythematosus; CRC cis rs11864453 0.963 rs7185215 chr16:72034864 T/C cg23815491 chr16:72088622 HP 0.55 8.39 0.42 1.48e-15 Fibrinogen levels; CRC cis rs597539 0.652 rs1249474 chr11:68654774 C/T cg06112835 chr11:68658793 MRPL21 0.43 7.06 0.36 9.66e-12 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs7605827 0.930 rs13384921 chr2:15602840 C/T cg19274914 chr2:15703543 NA 0.38 5.79 0.3 1.67e-8 Educational attainment (years of education); CRC cis rs9487051 0.872 rs1111865 chr6:109610863 A/G cg21918786 chr6:109611834 NA 0.44 8.14 0.41 8.12e-15 Reticulocyte fraction of red cells; CRC cis rs7677751 0.848 rs7673625 chr4:55088586 C/T cg13615338 chr4:55094005 PDGFRA 0.42 6.01 0.31 4.81e-9 Corneal astigmatism; CRC cis rs11122272 0.735 rs2474625 chr1:231519331 A/G cg06096015 chr1:231504339 EGLN1 0.4 5.94 0.31 7.17e-9 Hemoglobin concentration; CRC trans rs2303319 0.504 rs62187612 chr2:162432494 A/G cg22677401 chr17:46026860 NA -0.7 -6.05 -0.32 3.89e-9 Cognitive function; CRC cis rs17433780 0.836 rs61798917 chr1:89506093 G/A cg09516651 chr1:89888402 LOC400759 0.46 7.42 0.38 9.84e-13 Carotid intima media thickness; CRC trans rs1814175 0.817 rs10128730 chr11:50023369 G/T cg15704280 chr7:45808275 SEPT13 -0.99 -20.61 -0.75 3.6e-61 Height; CRC cis rs897984 0.645 rs9938550 chr16:30999142 A/G cg00531865 chr16:30841666 NA 0.48 6.74 0.35 6.96e-11 Dementia with Lewy bodies; CRC cis rs10751667 0.666 rs11246357 chr11:963980 A/C cg23136738 chr11:925521 AP2A2 -0.41 -6.91 -0.36 2.55e-11 Alzheimer's disease (late onset); CRC cis rs9868809 0.505 rs56735597 chr3:48765168 A/G cg00383909 chr3:49044727 WDR6 0.92 9.0 0.44 1.79e-17 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; CRC cis rs11098499 0.722 rs17595727 chr4:120262074 C/T cg09307838 chr4:120376055 NA -0.61 -9.64 -0.47 1.6e-19 Corneal astigmatism; CRC cis rs9462027 0.628 rs11759151 chr6:34747603 C/T cg07306190 chr6:34760872 UHRF1BP1 -0.35 -6.23 -0.33 1.4e-9 Systemic lupus erythematosus; CRC cis rs12477438 0.798 rs10198293 chr2:99602929 C/T cg26064155 chr2:99771622 LIPT1;TSGA10 -0.79 -11.26 -0.53 4.44e-25 Chronic sinus infection; CRC cis rs9487051 0.676 rs9400267 chr6:109600164 T/C cg01475377 chr6:109611718 NA -0.37 -6.54 -0.34 2.41e-10 Reticulocyte fraction of red cells; CRC cis rs73206853 0.841 rs73206882 chr12:110840515 G/A cg12870014 chr12:110450643 ANKRD13A 0.77 8.37 0.42 1.64e-15 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC cis rs2404602 0.647 rs7178250 chr15:77099107 T/C cg03037974 chr15:76606532 NA -0.55 -8.24 -0.41 4.17e-15 Blood metabolite levels; CRC cis rs9916302 0.605 rs2879258 chr17:37399379 G/T cg07936489 chr17:37558343 FBXL20 -0.84 -9.04 -0.45 1.4e-17 Glomerular filtration rate (creatinine); CRC cis rs4727027 0.835 rs11767810 chr7:148774433 T/A cg23583168 chr7:148888333 NA -0.89 -15.16 -0.64 9.77e-40 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC cis rs354033 1.000 rs354045 chr7:149300608 G/T cg24335155 chr7:149193227 ZNF746 -0.38 -6.42 -0.33 4.82e-10 Multiple sclerosis; CRC cis rs55788414 0.860 rs1806875 chr16:81184069 T/C cg06400318 chr16:81190750 PKD1L2 -0.59 -6.76 -0.35 6.2e-11 Left ventricular obstructive tract defect (maternal effect); CRC cis rs2439831 0.850 rs28504496 chr15:44016883 C/T cg02155558 chr15:43621948 ADAL;LCMT2 0.72 7.74 0.39 1.26e-13 Lung cancer in ever smokers; CRC cis rs769267 0.965 rs12977937 chr19:19429975 C/G cg03709012 chr19:19516395 GATAD2A 0.69 10.56 0.5 1.18e-22 Tonsillectomy; CRC cis rs12900413 0.631 rs62023455 chr15:90301999 G/A cg24249390 chr15:90295951 MESP1 -0.61 -9.38 -0.46 1.15e-18 Coronary artery aneurysm in Kawasaki disease; CRC cis rs78456975 1.000 rs11898988 chr2:1560336 G/A cg01028140 chr2:1542097 TPO -0.58 -6.13 -0.32 2.54e-9 Placebo response in major depressive disorder (% change in symptom score); CRC cis rs28386778 0.863 rs7221573 chr17:61859390 G/A cg07362569 chr17:61921086 SMARCD2 0.39 5.96 0.31 6.34e-9 Prudent dietary pattern; CRC cis rs597539 0.652 rs11603827 chr11:68719221 C/T cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.81 13.13 0.59 5.72e-32 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs11190604 1.000 rs2273695 chr10:102259568 A/G cg16342193 chr10:102329863 NA -0.34 -5.85 -0.31 1.17e-8 Palmitoleic acid (16:1n-7) levels; CRC cis rs9300255 0.543 rs655293 chr12:123528405 G/A cg00376283 chr12:123451042 ABCB9 0.55 7.01 0.36 1.34e-11 Neutrophil percentage of white cells; CRC cis rs896854 0.818 rs896855 chr8:95959808 A/G cg16049864 chr8:95962084 TP53INP1 -0.66 -11.99 -0.55 9.75e-28 Type 2 diabetes; CRC cis rs10504229 0.593 rs116916898 chr8:57984958 G/A cg22535103 chr8:58192502 C8orf71 -0.79 -7.74 -0.39 1.22e-13 Developmental language disorder (linguistic errors); CRC cis rs2836974 0.681 rs8128827 chr21:40710547 C/T cg11890956 chr21:40555474 PSMG1 0.98 14.9 0.63 9.91e-39 Cognitive function; CRC cis rs13108904 0.935 rs4974575 chr4:1252028 A/G cg23123621 chr4:1343375 KIAA1530 0.34 6.1 0.32 3.01e-9 Obesity-related traits; CRC cis rs1215050 0.791 rs1530904 chr4:98805436 A/G cg05340658 chr4:99064831 C4orf37 0.47 6.96 0.36 1.84e-11 Waist-to-hip ratio adjusted for body mass index; CRC cis rs898097 0.812 rs8065641 chr17:80820259 A/G cg19046167 chr17:80928561 B3GNTL1 -0.42 -6.71 -0.35 8.61e-11 Breast cancer; CRC cis rs7781266 0.739 rs17576069 chr7:133066514 A/G cg03336402 chr7:133662267 EXOC4 0.51 6.04 0.32 4.11e-9 Educational attainment (college completion); CRC cis rs67340775 0.541 rs200979 chr6:27852357 G/A cg08798685 chr6:27730294 NA -0.57 -6.16 -0.32 2.13e-9 Lung cancer in ever smokers; CRC cis rs10504229 0.679 rs17801003 chr8:58050930 A/G cg21724239 chr8:58056113 NA 0.75 9.58 0.47 2.38e-19 Developmental language disorder (linguistic errors); CRC cis rs7632954 0.531 rs11720160 chr3:8517932 A/T cg03495237 chr3:8533978 NA -0.35 -6.44 -0.33 4.24e-10 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs1865760 0.713 rs1130000 chr6:25985396 A/G cg17691542 chr6:26056736 HIST1H1C 0.55 8.51 0.42 6.25e-16 Height; CRC trans rs61931739 0.500 rs56404399 chr12:34543101 A/G cg26384229 chr12:38710491 ALG10B 0.68 8.8 0.44 7.69e-17 Morning vs. evening chronotype; CRC trans rs2014572 0.967 rs4801452 chr19:57768066 A/G cg02674126 chr19:40336878 FBL 0.42 6.7 0.35 8.83e-11 Hyperactive-impulsive symptoms; CRC cis rs7259376 0.871 rs34187872 chr19:22607883 G/A cg02657401 chr19:22469223 NA 0.31 6.76 0.35 6.46e-11 Menopause (age at onset); CRC cis rs1799949 1.000 rs11653253 chr17:41182662 G/A cg01879757 chr17:41196368 BRCA1 -0.41 -6.06 -0.32 3.7e-9 Menopause (age at onset); CRC cis rs7072216 0.770 rs1061123 chr10:100176997 A/G cg26618903 chr10:100175079 PYROXD2 -0.43 -7.07 -0.36 9.63e-12 Metabolite levels; CRC cis rs875971 0.508 rs10242423 chr7:66059175 A/G cg11764359 chr7:65958608 NA -0.5 -7.75 -0.39 1.14e-13 Aortic root size; CRC cis rs703842 0.642 rs73123375 chr12:58063664 C/T cg18357645 chr12:58087776 OS9 -0.49 -5.74 -0.3 2.13e-8 Multiple sclerosis; CRC trans rs2243480 1.000 rs73142121 chr7:65311206 C/T cg10756647 chr7:56101905 PSPH 0.73 7.72 0.39 1.46e-13 Diabetic kidney disease; CRC cis rs7493 1.000 rs7786401 chr7:95034001 G/T cg01874867 chr7:94954059 PON1 -0.52 -6.6 -0.34 1.64e-10 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs12142240 0.698 rs67941619 chr1:46838219 A/G cg00530320 chr1:46809349 NSUN4 0.6 8.14 0.41 8.41e-15 Menopause (age at onset); CRC cis rs877282 0.945 rs71491303 chr10:772884 G/T cg06581033 chr10:766294 NA -0.47 -5.71 -0.3 2.58e-8 Uric acid levels; CRC cis rs1862618 0.853 rs832584 chr5:56179212 A/G cg18230493 chr5:56204884 C5orf35 0.69 9.28 0.46 2.32e-18 Initial pursuit acceleration; CRC cis rs9560113 1.000 rs9555811 chr13:112181532 A/C cg10483660 chr13:112241077 NA 0.36 5.81 0.31 1.46e-8 Menarche (age at onset); CRC cis rs968567 0.817 rs61896141 chr11:61556039 A/C cg16576620 chr11:61596068 FADS2 -0.51 -6.68 -0.35 1.01e-10 Blood metabolite levels;Rheumatoid arthritis;Vitiligo;Glycerophospholipid levels; CRC cis rs55823223 0.503 rs9906971 chr17:73848477 A/G cg14829360 chr17:73884958 NA -0.44 -7.05 -0.36 1.07e-11 Psoriasis; CRC cis rs1957429 0.614 rs73279823 chr14:65351315 A/G cg23373153 chr14:65346875 NA -0.65 -5.89 -0.31 9.49e-9 Pediatric areal bone mineral density (radius); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg04328701 chr17:40761179 FAM134C;TUBG1 0.45 6.33 0.33 8.03e-10 Response to antipsychotic treatment; CRC cis rs7258465 1.000 rs34256197 chr19:18606472 G/A cg01065977 chr19:18549689 ISYNA1 -0.41 -6.38 -0.33 6.05e-10 Breast cancer; CRC trans rs6550704 0.687 rs9865314 chr3:22634337 A/G cg08132132 chr8:82644559 CHMP4C -0.38 -6.31 -0.33 9.01e-10 Daytime sleep phenotypes; CRC cis rs7772486 0.875 rs865913 chr6:146308874 C/T cg23711669 chr6:146136114 FBXO30 0.69 11.68 0.54 1.28e-26 Lobe attachment (rater-scored or self-reported); CRC trans rs1973993 0.745 rs9437743 chr1:96961723 C/T cg10631902 chr5:14652156 NA 0.41 6.86 0.35 3.33e-11 Weight; CRC cis rs8177253 0.965 rs8177245 chr3:133479230 A/G cg16262614 chr3:133464971 TF 0.34 6.01 0.31 4.93e-9 Iron status biomarkers; CRC cis rs9611565 0.729 rs203319 chr22:41914593 C/T cg03806693 chr22:41940476 POLR3H -0.79 -11.42 -0.53 1.15e-25 Vitiligo; CRC cis rs360798 0.532 rs13013218 chr2:63011671 C/T cg17519650 chr2:63277830 OTX1 -0.44 -6.15 -0.32 2.19e-9 Coronary artery disease; CRC cis rs6570726 0.935 rs397418 chr6:145842362 C/T cg05347473 chr6:146136440 FBXO30 0.38 6.13 0.32 2.58e-9 Lobe attachment (rater-scored or self-reported); CRC trans rs2976388 0.647 rs2164307 chr8:143788831 A/T cg24628676 chr5:59189846 PDE4D -0.3 -6.08 -0.32 3.3e-9 Urinary tract infection frequency; CRC cis rs644148 0.836 rs2686776 chr19:45000366 T/C cg15540054 chr19:45004280 ZNF180 -0.59 -8.28 -0.42 3.11e-15 Personality dimensions; CRC cis rs4253772 0.550 rs6008615 chr22:46707928 G/A cg03482458 chr22:46692211 CN5H6.4;GTSE1 0.5 5.95 0.31 6.97e-9 LDL cholesterol;Cholesterol, total; CRC trans rs4942242 0.640 rs9533571 chr13:44230136 C/T cg27382691 chr15:76552771 ETFA;TYRO3P -0.44 -6.04 -0.32 4.06e-9 Response to tocilizumab in rheumatoid arthritis; CRC cis rs9467711 0.591 rs6940007 chr6:25931957 A/C cg08501292 chr6:25962987 TRIM38 0.96 9.14 0.45 6.69e-18 Autism spectrum disorder or schizophrenia; CRC cis rs2658782 0.951 rs2608214 chr11:93148665 C/T cg15737290 chr11:93063684 CCDC67 0.47 6.87 0.35 3.31e-11 Pulmonary function decline; CRC cis rs9858542 0.953 rs6803222 chr3:49665976 T/G cg00383909 chr3:49044727 WDR6 0.48 5.92 0.31 7.98e-9 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC trans rs629535 0.590 rs62513426 chr8:70136843 T/G cg21567404 chr3:27674614 NA -0.91 -13.22 -0.59 2.63e-32 Dupuytren's disease; CRC cis rs2204008 0.840 rs11181795 chr12:38401129 A/G cg26384229 chr12:38710491 ALG10B 0.7 9.81 0.48 4.41e-20 Bladder cancer; CRC cis rs896543 0.702 rs6715324 chr2:237495510 C/T cg25295825 chr2:237489920 CXCR7 0.46 7.58 0.39 3.55e-13 Alcohol dependence (age at onset); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg14071762 chr20:61904060 ARFGAP1 0.38 6.17 0.32 1.99e-9 Intelligence (multi-trait analysis); CRC trans rs7615952 0.546 rs11717632 chr3:125321130 G/C cg02007433 chr3:129722099 NA -0.51 -6.2 -0.32 1.67e-9 Blood pressure (smoking interaction); CRC cis rs7617773 0.743 rs4632568 chr3:48367819 C/T cg11946769 chr3:48343235 NME6 0.72 9.58 0.47 2.48e-19 Coronary artery disease; CRC cis rs4561483 0.583 rs11075030 chr16:11976414 C/A cg08843971 chr16:11963173 GSPT1 0.51 7.63 0.39 2.49e-13 Testicular germ cell tumor; CRC cis rs9747201 0.925 rs11867806 chr17:80072049 A/G cg14673194 chr17:80132900 CCDC57 0.5 6.59 0.34 1.75e-10 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs7312774 0.881 rs7297923 chr12:107305573 T/C cg16260113 chr12:107380972 MTERFD3 0.74 7.49 0.38 6.43e-13 Severe influenza A (H1N1) infection; CRC cis rs9911578 1.000 rs6503887 chr17:56993320 T/C cg05425664 chr17:57184151 TRIM37 -0.5 -7.81 -0.4 7.69e-14 Intelligence (multi-trait analysis); CRC cis rs4731207 0.671 rs12530981 chr7:124521722 C/T cg23710748 chr7:124431027 NA -0.38 -6.08 -0.32 3.42e-9 Cutaneous malignant melanoma; CRC cis rs2635047 0.624 rs2289036 chr18:44595809 A/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 -0.42 -6.21 -0.32 1.57e-9 Educational attainment; CRC cis rs34375054 0.525 rs7133864 chr12:125606180 C/T cg25124228 chr12:125621409 AACS -0.67 -10.81 -0.51 1.66e-23 Post bronchodilator FEV1/FVC ratio; CRC cis rs4662945 0.525 rs4662951 chr2:130256272 C/T cg05903289 chr2:130345205 NA -0.36 -6.84 -0.35 3.96e-11 Response to cytidine analogues (gemcitabine); CRC cis rs477895 0.653 rs2015226 chr11:63902534 C/T cg18225595 chr11:63971243 STIP1 0.57 7.54 0.38 4.59e-13 Mean platelet volume; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg26847753 chr15:44119241 WDR76 0.39 6.22 0.32 1.51e-9 Liver disease severity in Alagille syndrome; CRC trans rs783540 0.967 rs783529 chr15:83267981 A/G cg18393722 chr15:85113863 UBE2QP1 -0.38 -6.49 -0.34 3.1e-10 Schizophrenia; CRC cis rs896854 0.516 rs12679044 chr8:95891356 C/A cg16049864 chr8:95962084 TP53INP1 -0.55 -9.09 -0.45 9.55e-18 Type 2 diabetes; CRC cis rs853679 1.000 rs11965538 chr6:28239915 G/A cg03623178 chr6:28175578 NA 0.73 7.35 0.38 1.57e-12 Depression; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg10546176 chr5:34929404 DNAJC21 0.41 7.19 0.37 4.49e-12 Liver disease severity in Alagille syndrome; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg26546685 chr4:100870642 LOC256880;H2AFZ 0.5 6.82 0.35 4.39e-11 Anxiety disorder; CRC cis rs75920871 0.557 rs11216275 chr11:116975704 T/G cg01368799 chr11:117014884 PAFAH1B2 -0.55 -7.07 -0.36 9.14e-12 Subjective well-being; CRC cis rs9393692 0.905 rs7769028 chr6:26267568 C/T cg13736514 chr6:26305472 NA -0.61 -11.34 -0.53 2.13e-25 Educational attainment; CRC cis rs7647973 0.559 rs9586 chr3:49213637 C/T cg20833759 chr3:49053208 WDR6;DALRD3 0.45 6.49 0.34 3.19e-10 Menarche (age at onset); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg26271690 chr1:202830559 LOC148709 0.45 6.4 0.33 5.33e-10 Response to antipsychotic treatment; CRC cis rs9326248 1.000 rs664922 chr11:117070895 C/A cg10398005 chr11:117014888 PAFAH1B2 -0.4 -5.69 -0.3 2.75e-8 Blood protein levels; CRC cis rs9486715 0.867 rs4839828 chr6:96863326 G/A cg18709589 chr6:96969512 KIAA0776 0.48 7.02 0.36 1.25e-11 Headache; CRC cis rs2070488 0.965 rs7373828 chr3:38524311 A/G cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.85 15.52 0.65 3.72e-41 Electrocardiographic conduction measures; CRC cis rs728616 0.558 rs55803802 chr10:81752664 A/G cg05935833 chr10:81318306 SFTPA2 -0.54 -7.02 -0.36 1.31e-11 Chronic obstructive pulmonary disease-related biomarkers; CRC trans rs11039798 0.588 rs1814768 chr11:48987455 T/C cg15704280 chr7:45808275 SEPT13 0.62 6.42 0.33 4.73e-10 Axial length; CRC cis rs10540 1.000 rs71487292 chr11:486076 G/A cg19913688 chr11:428466 ANO9 -0.73 -6.95 -0.36 1.93e-11 Body mass index; CRC cis rs875971 1.000 rs2420591 chr7:65912381 T/C cg12463550 chr7:65579703 CRCP 0.48 6.78 0.35 5.54e-11 Aortic root size; CRC cis rs76878669 0.561 rs4630308 chr11:66162587 G/A cg18002602 chr11:66138449 SLC29A2 0.27 5.84 0.31 1.22e-8 Educational attainment (years of education); CRC cis rs4665809 0.590 rs2891496 chr2:26452605 G/A cg04944784 chr2:26401820 FAM59B 0.85 11.05 0.52 2.29e-24 Gut microbiome composition (summer); CRC cis rs3858526 0.883 rs7481923 chr11:5933342 T/C cg02574844 chr11:5959923 NA -0.41 -5.75 -0.3 2.08e-8 DNA methylation (variation); CRC cis rs7937682 0.632 rs10789850 chr11:111750829 C/T cg19812747 chr11:111475976 SIK2 0.43 6.2 0.32 1.69e-9 Primary sclerosing cholangitis; CRC cis rs6540559 0.611 rs6540563 chr1:210019858 C/G cg22029157 chr1:209979665 IRF6 0.67 7.69 0.39 1.77e-13 Cleft lip with or without cleft palate; CRC cis rs9649213 0.593 rs6969731 chr7:97924571 T/G cg00277769 chr7:97922759 BAIAP2L1 -0.61 -10.74 -0.51 2.82e-23 Prostate cancer (SNP x SNP interaction); CRC cis rs4478858 0.684 rs10798837 chr1:31719340 C/T cg00250761 chr1:31883323 NA -0.43 -8.49 -0.42 7.13e-16 Alcohol dependence; CRC cis rs853679 0.517 rs9348796 chr6:28126202 A/G cg15845792 chr6:28175446 NA 1.04 13.89 0.61 7.67e-35 Depression; CRC cis rs7552404 0.727 rs6678348 chr1:76332463 C/T cg22875332 chr1:76189707 ACADM 0.54 6.95 0.36 1.98e-11 Blood metabolite levels;Acylcarnitine levels; CRC cis rs35110281 0.693 rs2251253 chr21:45092257 T/A cg01579765 chr21:45077557 HSF2BP -0.36 -6.89 -0.36 2.78e-11 Mean corpuscular volume; CRC cis rs651907 0.557 rs7629753 chr3:101371922 C/T cg12386194 chr3:101231763 SENP7 -0.48 -6.96 -0.36 1.86e-11 Colorectal cancer; CRC trans rs7647973 0.626 rs62260720 chr3:49853796 T/A cg21665057 chr3:196295764 WDR53;FBXO45 0.64 7.08 0.36 8.65e-12 Menarche (age at onset); CRC cis rs3008870 0.583 rs2815369 chr1:67500894 T/C cg08660285 chr1:67390436 MIER1;WDR78 1.01 12.31 0.56 6.54e-29 Lymphocyte percentage of white cells; CRC cis rs9911578 1.000 rs1971659 chr17:57004787 A/G cg12560992 chr17:57184187 TRIM37 0.92 17.18 0.69 1.12e-47 Intelligence (multi-trait analysis); CRC cis rs6866344 0.570 rs1079487 chr5:178136005 G/A cg10224037 chr5:178157518 ZNF354A 0.75 11.17 0.52 8.96e-25 Neutrophil percentage of white cells; CRC cis rs4713118 0.621 rs10484403 chr6:28033523 A/G cg18032046 chr6:28092343 ZSCAN16 -0.47 -5.61 -0.3 4.21e-8 Parkinson's disease; CRC cis rs875971 0.825 rs4587224 chr7:65736182 G/A cg18252515 chr7:66147081 NA 0.4 5.77 0.3 1.82e-8 Aortic root size; CRC cis rs17539620 0.628 rs11541340 chr6:154831572 C/G cg20019720 chr6:154832845 CNKSR3 0.52 8.71 0.43 1.5e-16 Lipoprotein (a) levels; CRC cis rs116095464 0.558 rs56298907 chr5:283280 C/A cg22857025 chr5:266934 NA -1.16 -12.06 -0.55 5.57e-28 Breast cancer; CRC cis rs720844 0.832 rs4972369 chr2:149287440 C/T cg09247360 chr2:149335327 NA -0.5 -6.02 -0.31 4.75e-9 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs1539053 0.932 rs11207086 chr1:58117341 A/C cg20292791 chr1:58089357 DAB1 -0.38 -6.73 -0.35 7.64e-11 Plasma omega-6 polyunsaturated fatty acid levels (arachidonic acid); CRC cis rs4819052 0.851 rs1999333 chr21:46670401 C/G cg19498844 chr21:46707878 POFUT2;LOC642852 0.75 10.72 0.51 3.27e-23 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg09974205 chr1:222638972 NA 0.49 6.27 0.33 1.11e-9 Thyroid stimulating hormone; CRC cis rs11112613 0.775 rs7299470 chr12:105961773 G/A cg03607813 chr12:105948248 NA 0.76 10.56 0.5 1.23e-22 Corrected insulin response;Corrected insulin response adjusted for insulin sensitivity index; CRC cis rs6866344 0.570 rs1132336 chr5:178140090 C/T cg10224037 chr5:178157518 ZNF354A 0.76 11.17 0.52 9.07e-25 Neutrophil percentage of white cells; CRC cis rs10760158 0.800 rs4836847 chr9:124058943 C/T cg14417974 chr9:124058376 GSN -0.33 -5.67 -0.3 3.1e-8 Pulse pressure; CRC cis rs6912958 0.500 rs4707352 chr6:87929705 G/A cg12350822 chr6:88032061 C6orf162;GJB7 -0.49 -9.96 -0.48 1.39e-20 Monocyte percentage of white cells; CRC cis rs1552244 1.000 rs6781811 chr3:10121922 A/G cg13047869 chr3:10149882 C3orf24 -0.53 -7.35 -0.38 1.6e-12 Alzheimer's disease; CRC cis rs1218582 0.710 rs4845687 chr1:154878911 A/G cg16680214 chr1:154839983 KCNN3 -0.45 -8.95 -0.44 2.64e-17 Prostate cancer; CRC cis rs4757319 0.515 rs10832437 chr11:15433225 C/T cg03245590 chr11:15329459 NA 0.52 9.24 0.45 3.06e-18 Breast cancer; CRC trans rs7819412 0.540 rs2409725 chr8:11041661 T/C cg16141378 chr3:129829833 LOC729375 0.42 6.17 0.32 2.05e-9 Triglycerides; CRC cis rs1865760 0.566 rs9366634 chr6:26072396 C/G cg17691542 chr6:26056736 HIST1H1C 0.55 8.38 0.42 1.6e-15 Height; CRC cis rs3785574 0.962 rs2665799 chr17:61919723 A/G cg25654072 chr17:61904446 PSMC5;FTSJ3 0.44 6.1 0.32 3.05e-9 Height; CRC cis rs10504229 1.000 rs115548028 chr8:58170672 T/C cg01721255 chr8:58191610 C8orf71 0.49 6.17 0.32 2e-9 Developmental language disorder (linguistic errors); CRC cis rs801193 1.000 rs10234018 chr7:66146284 A/T cg11764359 chr7:65958608 NA -0.52 -8.22 -0.41 4.91e-15 Aortic root size; CRC cis rs11098499 0.779 rs10011097 chr4:120310359 T/G cg24375607 chr4:120327624 NA 0.51 7.8 0.39 8.42e-14 Corneal astigmatism; CRC cis rs10256972 0.900 rs7812072 chr7:1053862 A/G cg07308232 chr7:1071921 C7orf50 -0.46 -6.38 -0.33 5.84e-10 Longevity;Endometriosis; CRC cis rs17162190 0.698 rs55840663 chr1:26840826 G/A cg17456097 chr1:26900765 RPS6KA1 0.42 6.15 0.32 2.22e-9 Mean corpuscular volume; CRC cis rs9326248 0.861 rs7120449 chr11:117042899 T/C cg11861562 chr11:117069780 TAGLN 0.34 6.34 0.33 7.39e-10 Blood protein levels; CRC cis rs9894429 0.816 rs9747093 chr17:79584280 G/A cg21028142 chr17:79581711 NPLOC4 0.4 8.68 0.43 1.88e-16 Eye color traits; CRC trans rs6550704 0.687 rs9865314 chr3:22634337 A/G cg24350909 chr7:6677433 NA -0.44 -6.57 -0.34 1.95e-10 Daytime sleep phenotypes; CRC cis rs12936587 0.601 rs7212538 chr17:17554587 T/G cg09796270 chr17:17721594 SREBF1 -0.47 -8.0 -0.4 2.18e-14 Hip circumference;Coronary artery disease or large artery stroke;Coronary heart disease;Coronary artery disease; CRC cis rs8077889 0.619 rs1230399 chr17:41845403 C/T cg25876840 chr17:41920477 NA -0.41 -6.59 -0.34 1.75e-10 Triglycerides; CRC cis rs875971 0.660 rs10272357 chr7:66063074 G/A cg00343986 chr7:65444356 GUSB -0.5 -7.51 -0.38 5.69e-13 Aortic root size; CRC trans rs61931739 0.500 rs7955247 chr12:34126580 G/A cg26384229 chr12:38710491 ALG10B 0.52 6.85 0.35 3.62e-11 Morning vs. evening chronotype; CRC cis rs7605827 0.930 rs4668927 chr2:15706683 C/T cg19274914 chr2:15703543 NA 0.4 6.12 0.32 2.62e-9 Educational attainment (years of education); CRC cis rs3820928 1.000 rs1835158 chr2:227763993 C/A cg11843606 chr2:227700838 RHBDD1 -0.4 -5.69 -0.3 2.84e-8 Pulmonary function; CRC cis rs2721195 1.000 rs11542372 chr8:145677089 G/A cg26752003 chr8:145688521 CYHR1 0.57 9.82 0.48 3.93e-20 Age at first birth; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg00462763 chr11:64949223 CAPN1 0.44 6.17 0.32 2e-9 Response to antipsychotic treatment; CRC cis rs514406 0.929 rs11206035 chr1:53323571 T/C cg25767906 chr1:53392781 SCP2 -0.46 -7.39 -0.38 1.25e-12 Monocyte count; CRC cis rs4423214 0.879 rs1790330 chr11:71147825 C/T cg13043300 chr11:71146211 DHCR7 -0.44 -6.01 -0.31 4.82e-9 Vitamin D levels; CRC cis rs524281 0.861 rs10896090 chr11:65945186 A/G cg16950941 chr11:66035639 RAB1B -0.61 -7.24 -0.37 3.15e-12 Electroencephalogram traits; CRC cis rs763121 0.819 rs5750658 chr22:39060917 C/T cg06544989 chr22:39130855 UNC84B 0.45 6.86 0.35 3.33e-11 Menopause (age at onset); CRC cis rs4076764 0.958 rs6688181 chr1:163384193 C/T cg06092702 chr1:163392909 NA 0.53 8.3 0.42 2.67e-15 Motion sickness; CRC cis rs1348850 0.519 rs1544002 chr2:178529534 C/T cg27490568 chr2:178487706 NA 0.38 5.64 0.3 3.66e-8 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs853679 0.517 rs4713148 chr6:28115921 G/A cg03623178 chr6:28175578 NA 0.98 12.66 0.57 3.31e-30 Depression; CRC cis rs9926296 0.585 rs8058009 chr16:89856439 G/C cg08547343 chr16:90038815 CENPBD1;AFG3L1 -0.59 -5.8 -0.3 1.57e-8 Vitiligo; CRC cis rs58688157 0.705 rs2396545 chr11:601785 T/C cg03909863 chr11:638404 DRD4 -0.53 -7.29 -0.37 2.38e-12 Systemic lupus erythematosus; CRC cis rs2072510 0.569 rs2540488 chr12:96426745 G/A cg22491680 chr12:96389547 HAL -0.5 -6.16 -0.32 2.13e-9 Metabolite levels (small molecules and protein measures); CRC cis rs4285028 0.948 rs12630486 chr3:121685267 C/T cg11130432 chr3:121712080 ILDR1 -0.52 -6.75 -0.35 6.81e-11 Multiple sclerosis; CRC cis rs896543 0.702 rs12692190 chr2:237496190 C/T cg25295825 chr2:237489920 CXCR7 0.47 7.83 0.4 6.98e-14 Alcohol dependence (age at onset); CRC cis rs7635838 0.617 rs2606731 chr3:11291615 A/C cg00170343 chr3:11313890 ATG7 0.55 8.55 0.43 4.63e-16 HDL cholesterol; CRC cis rs13191362 1.000 rs36007635 chr6:163009335 G/A cg23758597 chr6:163146217 PARK2 -0.55 -6.12 -0.32 2.7e-9 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC trans rs2797369 0.713 rs2813655 chr6:101586319 T/G cg26346621 chr12:6873348 NA 0.38 6.03 0.32 4.45e-9 Renal function-related traits (eGRFcrea); CRC cis rs6951245 0.706 rs28522260 chr7:1183964 C/A cg04025307 chr7:1156635 C7orf50 0.65 7.38 0.38 1.34e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC trans rs208520 0.690 rs2126120 chr6:66742754 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 1.05 14.83 0.63 1.81e-38 Exhaled nitric oxide output; CRC trans rs9914544 0.545 rs12451200 chr17:18778493 A/G cg21372672 chr17:16614065 CCDC144A -0.38 -6.02 -0.31 4.74e-9 Educational attainment (years of education); CRC cis rs7412746 0.658 rs6658066 chr1:150918937 T/G cg15448220 chr1:150897856 SETDB1 0.48 7.12 0.37 6.62e-12 Melanoma; CRC cis rs611744 0.604 rs6469170 chr8:109305277 T/C cg18478394 chr8:109455254 TTC35 0.43 6.44 0.33 4.34e-10 Dupuytren's disease; CRC cis rs6496667 0.642 rs12148876 chr15:91065208 G/A cg04176472 chr15:90893244 GABARAPL3 0.51 7.64 0.39 2.41e-13 Rheumatoid arthritis; CRC trans rs7937682 0.855 rs490897 chr11:111487914 A/G cg18187862 chr3:45730750 SACM1L 0.45 6.47 0.34 3.61e-10 Primary sclerosing cholangitis; CRC cis rs1223397 0.702 rs13191897 chr6:13288428 G/A cg00460589 chr6:13274354 PHACTR1 0.5 6.04 0.32 4.08e-9 Blood pressure; CRC cis rs789859 0.965 rs789858 chr3:194405966 C/T cg02072170 chr3:194406190 FAM43A 0.42 7.13 0.37 6.42e-12 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; CRC trans rs2270927 1.000 rs13174383 chr5:75580416 T/G cg13563193 chr19:33072644 PDCD5 0.74 7.89 0.4 4.64e-14 Mean corpuscular volume; CRC cis rs76878669 0.561 rs55998145 chr11:66152586 A/G cg24851651 chr11:66362959 CCS -0.39 -6.69 -0.35 9.43e-11 Educational attainment (years of education); CRC cis rs11997175 0.574 rs4733453 chr8:33650745 A/G ch.8.33884649F chr8:33765107 NA 0.49 7.66 0.39 2.1e-13 Body mass index; CRC cis rs1005277 0.579 rs1548255 chr10:38417193 T/C cg00409905 chr10:38381863 ZNF37A -0.67 -11.13 -0.52 1.25e-24 Extrinsic epigenetic age acceleration; CRC cis rs507506 0.771 rs929229 chr17:7105399 C/T cg14660024 chr17:7154518 C17orf81;DULLARD -0.47 -7.42 -0.38 1.04e-12 Adiponectin levels; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg13662262 chr21:30364895 RNF160 0.49 6.26 0.33 1.18e-9 Thyroid stimulating hormone; CRC cis rs2658782 0.724 rs2605626 chr11:93253903 A/G cg15737290 chr11:93063684 CCDC67 0.55 7.51 0.38 5.58e-13 Pulmonary function decline; CRC cis rs2252790 1.000 rs12214926 chr6:116643292 C/T cg18764771 chr6:116381957 FRK 0.22 5.75 0.3 2e-8 Fast beta electroencephalogram; CRC cis rs9660992 0.700 rs1172125 chr1:205258442 A/T cg21643547 chr1:205240462 TMCC2 -0.46 -7.83 -0.4 6.96e-14 Mean corpuscular volume;Mean platelet volume; CRC cis rs561341 1.000 rs530209 chr17:30315287 A/G cg00745463 chr17:30367425 LRRC37B -0.89 -9.87 -0.48 2.65e-20 Hip circumference adjusted for BMI; CRC cis rs12477438 0.798 rs10198293 chr2:99602929 C/T cg14399236 chr2:99771627 LIPT1;TSGA10 -0.74 -10.37 -0.5 5.51e-22 Chronic sinus infection; CRC cis rs853679 0.517 rs9348796 chr6:28126202 A/G cg03623178 chr6:28175578 NA 0.98 12.66 0.57 3.31e-30 Depression; CRC cis rs684232 0.666 rs366151 chr17:598311 A/C cg15660573 chr17:549704 VPS53 -0.77 -13.48 -0.6 2.84e-33 Prostate cancer; CRC cis rs11122272 0.705 rs2572260 chr1:231486189 T/C cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.52 -7.77 -0.39 1.03e-13 Hemoglobin concentration; CRC trans rs6600671 0.934 rs11249429 chr1:121291080 C/T cg17023122 chr1:144479586 NA -0.42 -5.98 -0.31 5.89e-9 Hip geometry; CRC cis rs2839186 0.605 rs2839174 chr21:47676934 T/C cg26721908 chr21:47610096 LSS -0.37 -5.62 -0.3 4.15e-8 Testicular germ cell tumor; CRC cis rs2404602 0.692 rs58889902 chr15:77173070 A/C cg23625390 chr15:77176239 SCAPER 0.46 6.53 0.34 2.56e-10 Blood metabolite levels; CRC cis rs10210302 0.504 rs1000141 chr2:234242347 C/T cg07618928 chr2:234183455 ATG16L1;SCARNA5 0.46 6.91 0.36 2.58e-11 Crohn's disease; CRC cis rs8077889 1.000 rs2066725 chr17:41891473 A/G cg16892393 chr17:41919603 NA 0.47 7.33 0.37 1.78e-12 Triglycerides; CRC cis rs7208859 0.673 rs423151 chr17:28952286 A/G cg19761014 chr17:28927070 LRRC37B2 0.54 6.97 0.36 1.77e-11 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs6743376 0.509 rs1530552 chr2:113818120 G/T cg24553058 chr2:113831203 IL1F10 0.42 6.93 0.36 2.24e-11 Inflammatory biomarkers; CRC cis rs992157 0.698 rs6746089 chr2:219170377 A/G cg04731861 chr2:219085781 ARPC2 -0.3 -6.14 -0.32 2.37e-9 Colorectal cancer; CRC cis rs10504229 1.000 rs67188507 chr8:58187492 A/T cg22535103 chr8:58192502 C8orf71 -0.82 -12.27 -0.56 9.63e-29 Developmental language disorder (linguistic errors); CRC cis rs6460942 1.000 rs73053531 chr7:12317474 T/C cg20607287 chr7:12443886 VWDE -0.64 -6.41 -0.33 5.11e-10 Coronary artery disease; CRC cis rs909002 0.800 rs7549590 chr1:32109849 G/A cg01639898 chr1:32083012 HCRTR1 0.31 6.43 0.33 4.39e-10 Intelligence (multi-trait analysis); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg08687137 chr11:62389499 B3GAT3 0.36 6.06 0.32 3.65e-9 Liver disease severity in Alagille syndrome; CRC cis rs2075371 1.000 rs2075371 chr7:133984127 A/G cg20476274 chr7:133979776 SLC35B4 0.8 14.55 0.63 2.31e-37 Mean platelet volume; CRC cis rs11252926 0.537 rs4881274 chr10:459940 G/A cg18196295 chr10:418757 DIP2C 0.48 7.53 0.38 4.83e-13 Psychosis in Alzheimer's disease; CRC cis rs6840360 1.000 rs749982 chr4:152601353 A/G cg09659197 chr4:152720779 NA 0.52 11.13 0.52 1.23e-24 Intelligence (multi-trait analysis); CRC cis rs2735413 0.914 rs12448754 chr16:78066747 T/C cg04733911 chr16:78082701 NA -0.37 -6.03 -0.32 4.33e-9 Systolic blood pressure (alcohol consumption interaction); CRC cis rs3008870 0.583 rs3008892 chr1:67373558 A/T cg08660285 chr1:67390436 MIER1;WDR78 0.98 12.86 0.58 6.11e-31 Lymphocyte percentage of white cells; CRC cis rs8177253 0.665 rs11921527 chr3:133441167 G/A cg16262614 chr3:133464971 TF 0.4 7.17 0.37 5.11e-12 Iron status biomarkers; CRC cis rs6502050 0.835 rs7406220 chr17:80077850 T/C cg09264619 chr17:80180166 NA 0.37 6.13 0.32 2.47e-9 Life satisfaction; CRC cis rs4925325 1.000 rs4925325 chr20:60514224 G/A cg23262073 chr20:60523788 NA 0.59 8.84 0.44 6.11e-17 Obesity-related traits; CRC cis rs4664293 0.867 rs7603274 chr2:160592690 G/C cg08347373 chr2:160653686 CD302 -0.47 -7.43 -0.38 9.32e-13 Monocyte percentage of white cells; CRC cis rs11122272 0.735 rs2572254 chr1:231512593 T/C cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.52 -7.82 -0.4 7.45e-14 Hemoglobin concentration; CRC cis rs2270875 1.000 rs10464830 chr8:132932383 C/T cg24184792 chr8:132919238 EFR3A -0.67 -6.7 -0.35 9.08e-11 Response to cholinesterase inhibitors in Alzheimer's disease; CRC cis rs25422 0.938 rs114309775 chr6:118838782 G/A cg07617317 chr6:118971624 C6orf204 0.5 6.25 0.33 1.25e-9 Renal cell carcinoma; CRC cis rs7811142 0.779 rs28680963 chr7:99905475 C/G cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.58 7.34 0.38 1.63e-12 Platelet count; CRC cis rs10504229 0.953 rs66815941 chr8:58187306 C/T cg02290350 chr8:58132656 NA -0.42 -5.96 -0.31 6.62e-9 Developmental language disorder (linguistic errors); CRC cis rs738322 0.935 rs2413503 chr22:38568944 A/T cg17652424 chr22:38574118 PLA2G6 -0.22 -6.81 -0.35 4.6e-11 Cutaneous nevi; CRC cis rs908922 0.535 rs11205006 chr1:152440176 A/T cg09873164 chr1:152488093 CRCT1 0.38 5.79 0.3 1.62e-8 Hair morphology; CRC cis rs1448094 0.967 rs7961782 chr12:86326461 T/C cg18827107 chr12:86230957 RASSF9 -0.37 -6.1 -0.32 2.98e-9 Major depressive disorder; CRC cis rs4862750 0.872 rs6553030 chr4:187899234 T/C cg10295955 chr4:187884368 NA -1.06 -28.72 -0.85 1.21e-91 Lobe attachment (rater-scored or self-reported); CRC cis rs4253772 0.550 rs6008615 chr22:46707928 G/A cg24881330 chr22:46731750 TRMU 0.59 6.29 0.33 1.01e-9 LDL cholesterol;Cholesterol, total; CRC cis rs939658 0.967 rs11629665 chr15:79457133 C/T cg17916960 chr15:79447300 NA 0.44 7.29 0.37 2.33e-12 Refractive error; CRC cis rs11098499 0.913 rs68128210 chr4:120137819 T/G cg24375607 chr4:120327624 NA 0.48 7.39 0.38 1.23e-12 Corneal astigmatism; CRC cis rs59104589 0.617 rs3771567 chr2:242358619 G/A cg19488206 chr2:242435732 STK25 0.45 6.63 0.34 1.34e-10 Fibrinogen levels; CRC cis rs7811142 0.830 rs78256546 chr7:99952970 A/G cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.62 8.0 0.4 2.19e-14 Platelet count; CRC cis rs600626 0.541 rs11236528 chr11:75469476 T/C cg24262691 chr11:75473276 NA 0.53 7.9 0.4 4.18e-14 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CRC cis rs919433 1.000 rs112572902 chr2:198175179 G/C cg03934865 chr2:198174659 NA -0.46 -8.35 -0.42 1.95e-15 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC cis rs9300255 0.568 rs1790090 chr12:123633424 G/A cg00376283 chr12:123451042 ABCB9 0.61 8.42 0.42 1.18e-15 Neutrophil percentage of white cells; CRC cis rs56283067 0.847 rs10456536 chr6:44692995 G/C cg18551225 chr6:44695536 NA -0.41 -5.97 -0.31 6.18e-9 Total body bone mineral density; CRC trans rs1005277 0.579 rs1740732 chr10:38491385 C/T cg27523141 chr10:43048294 ZNF37B 0.47 7.01 0.36 1.38e-11 Extrinsic epigenetic age acceleration; CRC cis rs9906695 0.898 rs3760396 chr17:32581441 G/C cg12698626 chr17:32581466 CCL2 0.47 6.12 0.32 2.61e-9 Monocyte percentage of white cells; CRC cis rs763121 0.719 rs9610995 chr22:39057763 C/T cg06022373 chr22:39101656 GTPBP1 0.79 12.53 0.57 1.04e-29 Menopause (age at onset); CRC cis rs1707322 1.000 rs6677777 chr1:46475836 A/G cg06784218 chr1:46089804 CCDC17 0.61 10.94 0.52 5.94e-24 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs60843830 1.000 rs36216559 chr2:262335 A/G cg00108164 chr2:264199 ACP1;SH3YL1 0.62 9.81 0.48 4.41e-20 Spherical equivalent (joint analysis main effects and education interaction); CRC cis rs853679 1.000 rs1679709 chr6:28228342 A/G cg15845792 chr6:28175446 NA -0.61 -6.14 -0.32 2.41e-9 Depression; CRC cis rs9903692 0.954 rs875065 chr17:46139569 C/T cg21215337 chr17:46176117 CBX1 0.43 7.83 0.4 6.68e-14 Pulse pressure; CRC cis rs4665809 0.590 rs4665315 chr2:26416036 T/G cg26119090 chr2:26468346 HADHA;HADHB -1.05 -15.29 -0.64 3.04e-40 Gut microbiome composition (summer); CRC cis rs9311474 0.508 rs7625743 chr3:52606366 C/G cg11645453 chr3:52864694 ITIH4 0.35 6.3 0.33 9.46e-10 Electroencephalogram traits; CRC cis rs12188164 0.965 rs11744539 chr5:451425 C/T cg21972741 chr5:435613 AHRR 0.55 7.56 0.38 4.15e-13 Cystic fibrosis severity; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg02717630 chr16:46865118 C16orf87 -0.43 -6.7 -0.35 8.88e-11 Myopia (pathological); CRC cis rs1129187 0.755 rs9471976 chr6:42920549 G/T cg10862848 chr6:42927986 GNMT -0.38 -9.09 -0.45 9.22e-18 Alzheimer's disease in APOE e4+ carriers; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg21962918 chr5:134094454 DDX46 -0.4 -6.12 -0.32 2.64e-9 Myopia (pathological); CRC cis rs4713118 0.955 rs9468204 chr6:27688809 C/T cg26587870 chr6:27730563 NA -0.42 -6.29 -0.33 9.83e-10 Parkinson's disease; CRC cis rs9659323 1.000 rs10923715 chr1:119535334 A/T cg26570165 chr1:119541833 NA 0.39 6.55 0.34 2.28e-10 Body mass index; CRC cis rs9403521 1.000 rs6907410 chr6:143995142 A/G cg18240653 chr6:144019428 PHACTR2 -0.55 -6.18 -0.32 1.85e-9 Obesity-related traits; CRC cis rs1552244 0.882 rs2030564 chr3:10039044 A/G cg18598329 chr3:10140678 FANCD2;C3orf24 -0.81 -10.68 -0.51 4.69e-23 Alzheimer's disease; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg07071157 chr11:72525331 ATG16L2 0.4 6.79 0.35 5.34e-11 Liver disease severity in Alagille syndrome; CRC cis rs10450586 0.764 rs6484287 chr11:27302272 T/A cg10370305 chr11:27303972 NA 0.38 6.14 0.32 2.37e-9 Total body bone mineral density; CRC trans rs1728785 1.000 rs821167 chr16:68577222 T/G cg04657470 chr2:198365150 HSPE1;HSPD1 0.77 8.96 0.44 2.51e-17 Ulcerative colitis; CRC cis rs3857067 0.806 rs2865343 chr4:95103005 C/T cg11021082 chr4:95130006 SMARCAD1 -0.49 -7.62 -0.39 2.68e-13 QT interval; CRC cis rs4728302 0.869 rs889826 chr7:133595871 A/G cg03336402 chr7:133662267 EXOC4 -0.45 -6.51 -0.34 2.78e-10 Intelligence;Intelligence (multi-trait analysis); CRC cis rs7826238 0.564 rs2921053 chr8:8319963 G/C cg08975724 chr8:8085496 FLJ10661 0.48 7.4 0.38 1.14e-12 Systolic blood pressure; CRC cis rs10504229 0.683 rs6998040 chr8:58110155 G/T cg21724239 chr8:58056113 NA -0.5 -6.75 -0.35 6.76e-11 Developmental language disorder (linguistic errors); CRC trans rs7615952 0.546 rs2979333 chr3:125360343 T/A cg02560186 chr11:3602584 NA -0.56 -7.1 -0.36 7.58e-12 Blood pressure (smoking interaction); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg25290303 chr17:6916095 RNASEK 0.42 6.07 0.32 3.46e-9 Intelligence (multi-trait analysis); CRC cis rs10504229 0.679 rs6995378 chr8:58113933 C/T cg02725872 chr8:58115012 NA -0.65 -11.61 -0.54 2.34e-26 Developmental language disorder (linguistic errors); CRC cis rs10463316 0.894 rs13357969 chr5:150751557 A/G cg03212797 chr5:150827313 SLC36A1 -0.52 -8.18 -0.41 6.14e-15 Metabolite levels (Pyroglutamine); CRC cis rs10876993 0.890 rs774887 chr12:58034835 A/G cg15848620 chr12:58087721 OS9 -0.62 -8.48 -0.42 7.49e-16 Celiac disease or Rheumatoid arthritis; CRC cis rs6088580 0.634 rs3746455 chr20:32957216 G/A cg24642439 chr20:33292090 TP53INP2 -0.41 -6.84 -0.35 3.95e-11 Glomerular filtration rate (creatinine); CRC cis rs4665809 0.590 rs5001914 chr2:26415429 A/G cg22920501 chr2:26401640 FAM59B -0.83 -11.79 -0.55 5.27e-27 Gut microbiome composition (summer); CRC cis rs9611565 0.659 rs73178632 chr22:41934573 C/T cg17554472 chr22:41940697 POLR3H -0.56 -5.89 -0.31 9.38e-9 Vitiligo; CRC cis rs7312933 0.584 rs6582391 chr12:42634686 G/A cg11827402 chr12:42719852 PPHLN1;ZCRB1 0.62 8.76 0.43 1.04e-16 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CRC cis rs4481887 0.927 rs4578248 chr1:248434069 G/A cg00666640 chr1:248458726 OR2T12 0.55 10.23 0.49 1.7e-21 Common traits (Other); CRC cis rs1552244 0.554 rs3846169 chr3:9997054 A/G cg00166722 chr3:10149974 C3orf24 -0.4 -6.16 -0.32 2.08e-9 Alzheimer's disease; CRC cis rs11190604 1.000 rs4919472 chr10:102315864 T/A cg16342193 chr10:102329863 NA -0.36 -5.9 -0.31 9.08e-9 Palmitoleic acid (16:1n-7) levels; CRC cis rs2836974 0.563 rs6517522 chr21:40553845 T/C cg17971929 chr21:40555470 PSMG1 0.61 8.89 0.44 4.18e-17 Cognitive function; CRC cis rs17376456 0.877 rs13156865 chr5:93390908 C/A cg25358565 chr5:93447407 FAM172A 0.99 10.61 0.5 8.17e-23 Diabetic retinopathy; CRC cis rs7493 0.901 rs2237586 chr7:95051052 G/T cg04155289 chr7:94953770 PON1 -0.63 -7.73 -0.39 1.32e-13 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs1448094 0.717 rs55811543 chr12:86290936 C/T cg18827107 chr12:86230957 RASSF9 -0.47 -7.5 -0.38 6.06e-13 Major depressive disorder; CRC cis rs6543140 0.964 rs10193485 chr2:103089573 T/C cg09003973 chr2:102972529 NA 0.42 5.93 0.31 7.87e-9 Blood protein levels; CRC cis rs6502050 0.799 rs8082355 chr17:80120316 A/G cg11859384 chr17:80120422 CCDC57 -0.36 -5.75 -0.3 2.06e-8 Life satisfaction; CRC cis rs875971 0.830 rs587360 chr7:65522698 C/A cg11764359 chr7:65958608 NA 0.57 9.05 0.45 1.29e-17 Aortic root size; CRC cis rs6502050 0.835 rs4789744 chr17:80101506 A/C cg09264619 chr17:80180166 NA -0.34 -5.81 -0.3 1.5e-8 Life satisfaction; CRC cis rs12999616 0.817 rs7425883 chr2:98331521 C/G cg26665480 chr2:98280029 ACTR1B -0.53 -6.55 -0.34 2.25e-10 Colorectal cancer; CRC cis rs2439831 0.681 rs28578454 chr15:43603032 G/A cg02155558 chr15:43621948 ADAL;LCMT2 0.74 8.02 0.4 1.91e-14 Lung cancer in ever smokers; CRC cis rs9457247 0.534 rs9347170 chr6:167405187 C/T cg23791538 chr6:167370224 RNASET2 0.54 8.98 0.44 2.2e-17 Crohn's disease; CRC trans rs11148252 0.740 rs9596642 chr13:52900879 A/G cg18335740 chr13:41363409 SLC25A15 -0.52 -7.63 -0.39 2.59e-13 Lewy body disease; CRC cis rs6714710 0.603 rs1875699 chr2:98580724 G/T cg26665480 chr2:98280029 ACTR1B 0.53 7.49 0.38 6.36e-13 Posterior cortical atrophy and Alzheimer's disease; CRC cis rs11229555 0.645 rs36019763 chr11:58232283 G/T cg15696309 chr11:58395628 NA -0.9 -11.51 -0.54 5.66e-26 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; CRC cis rs6942756 0.747 rs692432 chr7:129113287 G/A cg02491457 chr7:128862824 NA -0.59 -7.96 -0.4 2.83e-14 White matter hyperintensity burden; CRC cis rs7927592 0.913 rs4084149 chr11:68288567 A/G cg01657329 chr11:68192670 LRP5 -0.46 -6.56 -0.34 2.06e-10 Total body bone mineral density; CRC cis rs929354 0.713 rs3802129 chr7:156965297 G/A cg05182265 chr7:156933206 UBE3C -0.75 -14.06 -0.61 1.78e-35 Body mass index; CRC cis rs1580019 0.587 rs10951338 chr7:32560089 A/G cg06627557 chr7:32535165 LSM5;AVL9 0.96 18.19 0.71 1.2e-51 Cognitive ability; CRC cis rs2033711 0.870 rs7409473 chr19:58939165 A/G cg00825309 chr19:58991885 ZNF446 -0.45 -6.6 -0.34 1.64e-10 Uric acid clearance; CRC cis rs2019137 0.936 rs902696 chr2:113954879 G/T cg12889195 chr2:113992843 PAX8;LOC440839;LOC654433 0.5 7.09 0.36 8.22e-12 Lymphocyte counts; CRC cis rs7089973 0.584 rs4752322 chr10:116613258 A/C cg23260525 chr10:116636907 FAM160B1 0.4 9.38 0.46 1.11e-18 Bipolar disorder or attention deficit hyperactivity disorder; CRC cis rs7937682 0.632 rs11214009 chr11:111683142 T/C cg09085632 chr11:111637200 PPP2R1B 0.95 15.1 0.64 1.7e-39 Primary sclerosing cholangitis; CRC cis rs2549003 0.934 rs2549006 chr5:131827065 A/G cg21138405 chr5:131827807 IRF1 -0.6 -12.04 -0.55 6.81e-28 Asthma (sex interaction); CRC cis rs4332037 0.851 rs34040190 chr7:1920356 G/A cg23378565 chr7:2036160 MAD1L1 -0.47 -6.54 -0.34 2.3e-10 Bipolar disorder; CRC cis rs9303280 0.901 rs7216389 chr17:38069949 C/T cg11212589 chr17:38028394 ZPBP2 -0.44 -8.02 -0.4 1.89e-14 Self-reported allergy; CRC cis rs12476592 0.571 rs190519 chr2:63858425 T/A cg10828910 chr2:63850056 LOC388955 0.47 5.94 0.31 7.38e-9 Childhood ear infection; CRC cis rs3806843 0.576 rs246047 chr5:140328337 C/T cg19875535 chr5:140030758 IK 0.39 6.02 0.31 4.67e-9 Depressive symptoms (multi-trait analysis); CRC cis rs2228479 0.850 rs11649162 chr16:89807131 C/A cg06656553 chr16:89960601 TCF25 -0.68 -5.71 -0.3 2.55e-8 Skin colour saturation; CRC cis rs2108225 0.934 rs2283045 chr7:107440714 G/A cg18560240 chr7:107437656 SLC26A3 -0.55 -8.31 -0.42 2.53e-15 Ulcerative colitis; CRC cis rs3741151 0.686 rs17851510 chr11:73106294 A/C cg17517138 chr11:73019481 ARHGEF17 0.58 6.1 0.32 3.04e-9 GIP levels in response to oral glucose tolerance test (120 minutes); CRC cis rs4713118 0.784 rs9468219 chr6:27731755 C/A cg08798685 chr6:27730294 NA -0.49 -6.88 -0.35 3.11e-11 Parkinson's disease; CRC cis rs6558174 0.802 rs6558171 chr8:22487422 T/C cg03733263 chr8:22462867 KIAA1967 0.49 6.38 0.33 6.16e-10 Breast cancer; CRC cis rs9868809 0.772 rs73078349 chr3:48688114 G/A cg07636037 chr3:49044803 WDR6 -0.82 -5.94 -0.31 7.39e-9 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; CRC trans rs1941687 0.563 rs7232237 chr18:31324934 C/T cg27147174 chr7:100797783 AP1S1 0.37 6.09 0.32 3.1e-9 Subjective well-being (multi-trait analysis);Subjective well-being; CRC cis rs9649213 0.574 rs7802541 chr7:97933855 C/A cg24562669 chr7:97807699 LMTK2 0.44 7.37 0.38 1.4e-12 Prostate cancer (SNP x SNP interaction); CRC cis rs2857891 1.000 rs72845397 chr11:6950903 C/T cg22096450 chr11:6947773 ZNF215 0.61 6.38 0.33 6.15e-10 Response to cytadine analogues (cytosine arabinoside); CRC trans rs596169 0.655 rs6697647 chr1:219159834 A/G cg09853702 chr12:47665230 NA 0.8 6.23 0.32 1.41e-9 Intraocular pressure; CRC cis rs3617 0.522 rs6773650 chr3:52897095 A/T cg15147215 chr3:52552868 STAB1 -0.46 -7.5 -0.38 5.86e-13 Red blood cell count;Autism spectrum disorder or schizophrenia; CRC cis rs1949733 1.000 rs868105 chr4:8501030 G/T cg13073564 chr4:8508604 NA 0.5 7.51 0.38 5.52e-13 Response to antineoplastic agents; CRC cis rs1559088 0.948 rs7259333 chr19:33579128 T/C cg03563238 chr19:33554763 RHPN2 -0.31 -5.63 -0.3 3.87e-8 Bone ultrasound measurement (broadband ultrasound attenuation); CRC cis rs4820539 0.966 rs2267000 chr22:23455366 A/G cg14186256 chr22:23484241 RTDR1 0.87 16.84 0.68 2.55e-46 Bone mineral density; CRC cis rs7487075 0.820 rs4238102 chr12:46726496 T/A cg22049899 chr12:47219821 SLC38A4 0.35 6.87 0.35 3.18e-11 Itch intensity from mosquito bite; CRC cis rs10256972 0.577 rs4999286 chr7:1199506 C/G cg27094323 chr7:1216898 NA -0.35 -5.74 -0.3 2.19e-8 Longevity;Endometriosis; CRC cis rs4700695 0.841 rs44267 chr5:65274311 G/A cg21114390 chr5:65439923 SFRS12 0.59 6.63 0.34 1.35e-10 Facial morphology (factor 19); CRC cis rs807669 0.903 rs807666 chr22:19160549 C/T cg02655711 chr22:19163373 SLC25A1 0.99 20.38 0.75 2.8e-60 Metabolite levels; CRC cis rs13118159 0.778 rs12640984 chr4:1338834 G/A cg16524936 chr4:1340807 KIAA1530 -0.42 -5.79 -0.3 1.64e-8 Longevity; CRC cis rs10504229 1.000 rs6987435 chr8:58177334 G/A cg05313129 chr8:58192883 C8orf71 -0.46 -6.82 -0.35 4.29e-11 Developmental language disorder (linguistic errors); CRC cis rs7605827 0.930 rs6732252 chr2:15595473 T/C cg19274914 chr2:15703543 NA 0.38 5.79 0.3 1.62e-8 Educational attainment (years of education); CRC cis rs6921919 0.638 rs6456815 chr6:28306137 C/A cg06470822 chr6:28175283 NA 0.48 6.43 0.33 4.59e-10 Autism spectrum disorder or schizophrenia; CRC trans rs2243480 1.000 rs906134 chr7:65444288 G/C cg10756647 chr7:56101905 PSPH 0.72 7.69 0.39 1.71e-13 Diabetic kidney disease; CRC cis rs6693567 0.565 rs1313570 chr1:150342642 T/C cg15654264 chr1:150340011 RPRD2 0.39 6.01 0.31 5.05e-9 Migraine; CRC cis rs9325144 0.560 rs11183046 chr12:38655270 A/T cg26384229 chr12:38710491 ALG10B -0.56 -8.38 -0.42 1.54e-15 Morning vs. evening chronotype; CRC cis rs1008375 1.000 rs1860597 chr4:17657650 C/T cg16339924 chr4:17578868 LAP3 0.59 8.0 0.4 2.1e-14 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs34779708 0.966 rs4934536 chr10:35441169 A/G cg03585969 chr10:35415529 CREM 0.66 8.71 0.43 1.48e-16 Inflammatory bowel disease;Crohn's disease; CRC trans rs1814175 0.645 rs4598671 chr11:50003191 C/A cg03929089 chr4:120376271 NA -0.88 -15.84 -0.66 2.09e-42 Height; CRC cis rs4713118 0.513 rs149955 chr6:28036225 G/C cg12273811 chr6:28175739 NA 0.56 8.11 0.41 1.02e-14 Parkinson's disease; CRC trans rs12599106 0.624 rs2173885 chr16:34992749 G/A cg18110333 chr6:292329 DUSP22 -0.69 -10.18 -0.49 2.41e-21 Menopause (age at onset); CRC cis rs7618915 0.547 rs6768697 chr3:52703615 C/T cg08222913 chr3:52553049 STAB1 -0.34 -6.12 -0.32 2.7e-9 Bipolar disorder; CRC cis rs7811142 0.830 rs7792959 chr7:99972403 C/T cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.14 17.06 0.69 3.53e-47 Platelet count; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg00834958 chr7:100077147 TSC22D4 0.44 6.26 0.33 1.19e-9 Intelligence (multi-trait analysis); CRC cis rs12291225 0.639 rs61883858 chr11:14294708 C/T cg19336497 chr11:14380999 RRAS2 -0.51 -8.53 -0.43 5.24e-16 Sense of smell; CRC trans rs1728785 0.818 rs1069289 chr16:68585317 C/A cg04657470 chr2:198365150 HSPE1;HSPD1 0.77 9.05 0.45 1.23e-17 Ulcerative colitis; CRC cis rs10512697 0.772 rs13154653 chr5:3518916 C/A cg19473799 chr5:3511975 NA -0.83 -6.34 -0.33 7.66e-10 Immune response to smallpox vaccine (IL-6); CRC cis rs28735056 0.935 rs537962 chr18:77592660 C/G cg20368463 chr18:77673604 PQLC1 0.55 8.47 0.42 8.58e-16 Schizophrenia; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg07335843 chr2:133030691 NA -0.37 -6.73 -0.35 7.75e-11 Liver disease severity in Alagille syndrome; CRC cis rs1401999 1.000 rs4148575 chr3:183702275 A/G cg05044414 chr3:183734942 ABCC5 0.46 8.03 0.4 1.79e-14 Anterior chamber depth; CRC cis rs11122272 0.735 rs971534 chr1:231521971 C/A cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.54 -8.14 -0.41 7.99e-15 Hemoglobin concentration; CRC cis rs1465370 0.568 rs10253113 chr7:130009311 A/G cg03229158 chr7:130009420 NA 0.5 7.16 0.37 5.23e-12 Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction);Waist circumference adjusted for BMI in active individuals;Waist circumference adjusted for body mass index; CRC trans rs17685 0.712 rs6953342 chr7:75776753 T/C cg19862616 chr7:65841803 NCRNA00174 0.95 17.19 0.69 9.99e-48 Coffee consumption;Coffee consumption (cups per day); CRC cis rs35146811 0.844 rs13232115 chr7:99670932 T/C cg13334819 chr7:99746414 C7orf59 -0.54 -7.4 -0.38 1.12e-12 Coronary artery disease; CRC cis rs6076065 1.000 rs2405231 chr20:23342239 A/C cg11657817 chr20:23433608 CST11 0.38 6.1 0.32 2.98e-9 Facial morphology (factor 15, philtrum width); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg00303776 chr10:103454253 FBXW4 0.49 6.94 0.36 2.13e-11 Response to antipsychotic treatment; CRC trans rs2303319 0.504 rs58622044 chr2:162596287 A/G cg01919652 chr6:150259930 NA -0.69 -5.99 -0.31 5.48e-9 Cognitive function; CRC cis rs7937682 0.883 rs512669 chr11:111467893 G/A cg09085632 chr11:111637200 PPP2R1B -0.96 -18.36 -0.71 2.48e-52 Primary sclerosing cholangitis; CRC cis rs6684514 1.000 rs12121805 chr1:156257876 A/G cg16558208 chr1:156270281 VHLL 0.58 9.04 0.45 1.34e-17 Mean corpuscular hemoglobin concentration;Glycated hemoglobin levels; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg21685432 chr20:57556415 TH1L 0.35 6.06 0.32 3.79e-9 Liver disease severity in Alagille syndrome; CRC cis rs11677416 1.000 rs3783520 chr2:113544339 C/T cg27083787 chr2:113543245 IL1A 0.48 6.39 0.33 5.74e-10 Response to antipsychotic treatment in schizophrenia (working memory); CRC cis rs9788333 0.707 rs12584557 chr13:21886171 C/A cg21970626 chr13:21893289 NA -0.44 -8.36 -0.42 1.73e-15 Thiazide-induced adverse metabolic effects in hypertensive patients; CRC cis rs951366 0.617 rs823074 chr1:205774839 T/C cg26354017 chr1:205819088 PM20D1 0.93 16.02 0.66 4.17e-43 Menarche (age at onset); CRC cis rs9611565 0.579 rs73178621 chr22:41921665 A/G cg06634786 chr22:41940651 POLR3H -0.72 -8.33 -0.42 2.2e-15 Vitiligo; CRC cis rs1799949 1.000 rs2292595 chr17:41290674 G/C cg23758822 chr17:41437982 NA 0.79 13.41 0.59 5.14e-33 Menopause (age at onset); CRC cis rs801193 0.569 rs6978178 chr7:66123084 G/A cg11764359 chr7:65958608 NA -0.59 -8.7 -0.43 1.62e-16 Aortic root size; CRC cis rs12477438 0.748 rs7558239 chr2:99640581 G/C cg26064155 chr2:99771622 LIPT1;TSGA10 -0.79 -11.26 -0.53 4.29e-25 Chronic sinus infection; CRC cis rs2012796 0.785 rs61986593 chr14:81840659 G/A cg02996355 chr14:81879375 NA 0.6 9.23 0.45 3.34e-18 Night sleep phenotypes; CRC cis rs2816062 0.775 rs2816046 chr1:18893708 A/G cg18795169 chr1:18902165 NA -0.9 -18.14 -0.71 1.87e-51 Urate levels in lean individuals; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg19720077 chr14:51135033 SAV1 0.39 6.05 0.32 4.02e-9 Intelligence (multi-trait analysis); CRC cis rs9903692 0.909 rs9899275 chr17:46129315 C/T cg21215337 chr17:46176117 CBX1 0.43 7.83 0.4 6.68e-14 Pulse pressure; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg24415082 chr16:74700811 RFWD3 0.45 6.48 0.34 3.35e-10 Response to antipsychotic treatment; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg16442050 chr2:27294098 LOC100128731 0.47 6.75 0.35 6.69e-11 Response to antipsychotic treatment; CRC trans rs11098499 0.775 rs2002049 chr4:120257417 A/G cg25214090 chr10:38739885 LOC399744 0.54 8.52 0.43 5.9e-16 Corneal astigmatism; CRC cis rs35883536 0.647 rs1855630 chr1:101039979 C/G cg06223162 chr1:101003688 GPR88 -0.35 -6.38 -0.33 6.07e-10 Monocyte count; CRC cis rs13108904 0.901 rs4974594 chr4:1300480 C/T cg16405210 chr4:1374714 KIAA1530 0.4 5.66 0.3 3.34e-8 Obesity-related traits; CRC cis rs9399135 0.967 rs1041480 chr6:135373076 G/T cg24558204 chr6:135376177 HBS1L 0.49 7.75 0.39 1.18e-13 Red blood cell count; CRC cis rs731174 0.797 rs678511 chr1:38156427 T/C cg06917450 chr1:38156652 C1orf109 -0.52 -7.15 -0.37 5.79e-12 Prostate cancer (SNP x SNP interaction); CRC cis rs2976388 0.609 rs2585149 chr8:143793320 T/C cg04969067 chr8:143858791 LYNX1 0.45 7.58 0.39 3.66e-13 Urinary tract infection frequency; CRC cis rs1448094 0.621 rs7133309 chr12:86284078 T/C cg18827107 chr12:86230957 RASSF9 -0.44 -7.24 -0.37 3.28e-12 Major depressive disorder; CRC cis rs4969178 0.965 rs8075131 chr17:76394595 T/G cg05887092 chr17:76393375 PGS1 0.55 10.17 0.49 2.62e-21 HDL cholesterol levels; CRC cis rs10779751 0.960 rs4845857 chr1:11285680 T/C cg08854313 chr1:11322531 MTOR 0.67 9.81 0.48 4.23e-20 Body mass index; CRC cis rs60843830 0.928 rs2306060 chr2:230912 A/C cg00108164 chr2:264199 ACP1;SH3YL1 0.63 10.09 0.49 5.05e-21 Spherical equivalent (joint analysis main effects and education interaction); CRC cis rs875971 1.000 rs6961155 chr7:65933295 T/C cg18912574 chr7:65842487 NCRNA00174 0.36 6.1 0.32 2.97e-9 Aortic root size; CRC cis rs11098499 1.000 rs28419773 chr4:120211061 T/C cg24375607 chr4:120327624 NA 0.47 7.22 0.37 3.65e-12 Corneal astigmatism; CRC cis rs25645 0.830 rs4072639 chr17:38189049 G/A cg17344932 chr17:38183730 MED24;SNORD124 0.86 17.04 0.68 4.11e-47 Myeloid white cell count; CRC cis rs12220238 1.000 rs12359456 chr10:75937994 C/G cg19889307 chr10:75911429 ADK;AP3M1 0.6 5.74 0.3 2.17e-8 Soluble interleukin-2 receptor subunit alpha; CRC trans rs75804782 0.581 rs13415491 chr2:239319901 C/T cg01134436 chr17:81009848 B3GNTL1 0.77 7.02 0.36 1.24e-11 Morning vs. evening chronotype;Chronotype; CRC cis rs45509595 0.841 rs200501 chr6:27788942 C/T cg19041857 chr6:27730383 NA -0.72 -6.75 -0.35 6.7e-11 Breast cancer; CRC cis rs17711722 0.701 rs4467826 chr7:65368708 A/G cg18876405 chr7:65276391 NA 0.65 11.9 0.55 2.05e-27 Calcium levels; CRC cis rs796364 0.806 rs79156935 chr2:200913822 T/G cg25936922 chr2:200820526 C2orf60;C2orf47 -0.7 -6.57 -0.34 2.02e-10 Schizophrenia; CRC cis rs2898681 0.770 rs62336795 chr4:53737772 G/A cg00338735 chr4:53728038 RASL11B 0.36 5.77 0.3 1.84e-8 Optic nerve measurement (cup area); CRC cis rs11122272 0.735 rs2808597 chr1:231532351 T/C cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.58 -8.69 -0.43 1.69e-16 Hemoglobin concentration; CRC cis rs6502050 0.749 rs7209948 chr17:80086804 T/G cg11859384 chr17:80120422 CCDC57 0.37 5.83 0.31 1.36e-8 Life satisfaction; CRC cis rs9322193 0.926 rs2342860 chr6:150098777 T/C cg13206674 chr6:150067644 NUP43 0.57 8.14 0.41 8.29e-15 Lung cancer; CRC cis rs6121246 0.529 rs6060171 chr20:30183269 C/T cg18721089 chr20:30220636 NA -0.53 -8.03 -0.4 1.78e-14 Mean corpuscular hemoglobin; CRC cis rs1218582 0.710 rs9794000 chr1:154878876 T/A cg16680214 chr1:154839983 KCNN3 -0.46 -8.93 -0.44 3.13e-17 Prostate cancer; CRC cis rs3026101 0.671 rs1065482 chr17:5284719 T/C cg25236894 chr17:5323110 RPAIN;NUP88 0.45 7.47 0.38 7.09e-13 Body mass index; CRC cis rs6840360 0.638 rs6816002 chr4:152589439 C/T cg09659197 chr4:152720779 NA 0.44 8.93 0.44 3.05e-17 Intelligence (multi-trait analysis); CRC cis rs6570726 0.934 rs9484995 chr6:145781114 T/A cg23711669 chr6:146136114 FBXO30 -0.62 -10.3 -0.49 9.84e-22 Lobe attachment (rater-scored or self-reported); CRC trans rs3794271 0.706 rs9971816 chr12:20826911 C/T cg12888358 chr2:86668281 KDM3A -0.48 -6.61 -0.34 1.54e-10 Response to TNF-alpha inhibitors in rheumatoid arthritis; CRC trans rs11148252 0.538 rs2897976 chr13:52715944 G/A cg18335740 chr13:41363409 SLC25A15 0.53 7.94 0.4 3.21e-14 Lewy body disease; CRC cis rs7224685 0.501 rs11649992 chr17:4026823 A/C cg10724054 chr17:3904396 NA 0.48 7.64 0.39 2.34e-13 Type 2 diabetes; CRC cis rs17345786 1.000 rs55641278 chr3:101290577 G/A cg11279151 chr3:101281821 RG9MTD1 -0.66 -8.21 -0.41 5.12e-15 Colonoscopy-negative controls vs population controls; CRC cis rs34172651 0.917 rs11074654 chr16:24813743 A/G cg06028605 chr16:24865363 SLC5A11 0.4 7.47 0.38 7.28e-13 Intelligence (multi-trait analysis); CRC cis rs208520 0.690 rs207091 chr6:66799847 G/T cg07460842 chr6:66804631 NA -1.08 -15.25 -0.64 4.51e-40 Exhaled nitric oxide output; CRC cis rs4713118 0.662 rs149961 chr6:28015569 A/C cg21251018 chr6:28226885 NKAPL 0.46 6.52 0.34 2.59e-10 Parkinson's disease; CRC cis rs990171 0.913 rs10190555 chr2:102994056 A/G cg03938978 chr2:103052716 IL18RAP 0.46 5.77 0.3 1.82e-8 Lymphocyte counts; CRC cis rs12477438 0.765 rs1115757 chr2:99660146 G/A cg26064155 chr2:99771622 LIPT1;TSGA10 -0.63 -8.55 -0.43 4.61e-16 Chronic sinus infection; CRC cis rs853679 0.517 rs9368550 chr6:28051803 T/A cg15786705 chr6:28176104 NA 0.74 9.47 0.46 5.74e-19 Depression; CRC cis rs2239547 0.522 rs2336162 chr3:52951519 C/T cg10802521 chr3:52805072 NEK4 0.41 5.69 0.3 2.86e-8 Schizophrenia; CRC cis rs2050392 0.894 rs2480277 chr10:30703513 G/T cg18806716 chr10:30721971 MAP3K8 0.5 7.51 0.38 5.6e-13 Inflammatory bowel disease; CRC trans rs9467711 0.659 rs35433030 chr6:26529890 G/A cg06606381 chr12:133084897 FBRSL1 -1.07 -7.41 -0.38 1.09e-12 Autism spectrum disorder or schizophrenia; CRC cis rs1580019 0.961 rs11768506 chr7:32494788 A/C cg06627557 chr7:32535165 LSM5;AVL9 0.71 11.2 0.53 6.71e-25 Cognitive ability; CRC cis rs11997175 0.846 rs34860600 chr8:33761566 C/A cg04338863 chr8:33670619 NA 0.38 6.09 0.32 3.13e-9 Body mass index; CRC cis rs4285028 0.747 rs4048703 chr3:121374361 G/A cg20356878 chr3:121714668 ILDR1 -0.44 -5.97 -0.31 6.14e-9 Multiple sclerosis; CRC cis rs7591163 1.000 rs6436741 chr2:228714598 G/A cg00063174 chr2:228736253 WDR69 -0.51 -6.86 -0.35 3.49e-11 Blood pressure; CRC cis rs11971779 0.774 rs6467838 chr7:139043501 A/G cg07862535 chr7:139043722 LUC7L2 0.57 7.35 0.38 1.61e-12 Diisocyanate-induced asthma; CRC cis rs62229266 0.659 rs7275820 chr21:37409414 G/A cg08632701 chr21:37451849 NA -0.4 -6.27 -0.33 1.16e-9 Mitral valve prolapse; CRC cis rs9914988 0.887 rs11650282 chr17:27090741 C/G cg07195577 chr17:27052828 TLCD1 0.42 6.03 0.32 4.32e-9 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs61160187 0.582 rs34619 chr5:60465365 G/A cg16298547 chr5:60138761 ELOVL7 -0.27 -5.69 -0.3 2.85e-8 Educational attainment (years of education);Educational attainment (college completion); CRC cis rs9291683 0.530 rs4235346 chr4:9945296 C/T cg11266682 chr4:10021025 SLC2A9 -0.49 -9.9 -0.48 2.08e-20 Bone mineral density; CRC cis rs79057730 0.599 rs4721086 chr7:821123 G/A cg11064039 chr7:766100 PRKAR1B;HEATR2 0.57 6.0 0.31 5.13e-9 Initial pursuit acceleration; CRC cis rs9914988 0.943 rs9915673 chr17:27132893 G/C cg20469991 chr17:27169893 C17orf63 -0.6 -7.27 -0.37 2.59e-12 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs854765 0.583 rs9912895 chr17:17826020 C/T cg09796270 chr17:17721594 SREBF1 -0.55 -9.92 -0.48 1.87e-20 Total body bone mineral density; CRC cis rs9916302 0.904 rs602282 chr17:37433021 C/T cg15445000 chr17:37608096 MED1 0.42 9.09 0.45 9.39e-18 Glomerular filtration rate (creatinine); CRC cis rs7095944 0.614 rs10901816 chr10:126440395 G/A cg08799069 chr10:126477246 METTL10 -0.44 -6.84 -0.35 3.81e-11 Asthma; CRC cis rs11958404 0.860 rs72818116 chr5:157440616 G/T cg05962755 chr5:157440814 NA 0.96 12.14 0.56 2.72e-28 IgG glycosylation; CRC cis rs853679 0.517 rs9368556 chr6:28131153 T/C cg21251018 chr6:28226885 NKAPL 0.48 6.17 0.32 2.02e-9 Depression; CRC cis rs11098499 0.863 rs12502389 chr4:120454191 A/G cg24375607 chr4:120327624 NA 0.47 7.05 0.36 1.06e-11 Corneal astigmatism; CRC cis rs897984 0.609 rs732172 chr16:31050033 C/T cg02466173 chr16:30829666 NA -0.61 -9.25 -0.45 2.95e-18 Dementia with Lewy bodies; CRC cis rs6952808 0.792 rs11771973 chr7:1950440 C/G cg04267008 chr7:1944627 MAD1L1 -0.83 -12.66 -0.57 3.32e-30 Bipolar disorder and schizophrenia; CRC cis rs13108904 0.539 rs13141169 chr4:1340353 C/T cg15763984 chr4:1342303 KIAA1530 0.45 6.78 0.35 5.42e-11 Obesity-related traits; CRC trans rs941408 1.000 rs1736180 chr19:2796021 C/T cg19676328 chr12:49525230 TUBA1B -0.67 -10.44 -0.5 3.12e-22 Total cholesterol levels; CRC cis rs9303280 0.806 rs35569035 chr17:38035624 C/T cg20243544 chr17:37824526 PNMT 0.37 5.62 0.3 4.05e-8 Self-reported allergy; CRC cis rs7772486 0.719 rs702307 chr6:145993454 C/G cg23711669 chr6:146136114 FBXO30 -0.74 -12.68 -0.57 2.92e-30 Lobe attachment (rater-scored or self-reported); CRC cis rs17666538 0.585 rs1703927 chr8:613620 A/G cg23958373 chr8:599963 NA -0.7 -6.85 -0.35 3.61e-11 IgG glycosylation; CRC trans rs62209635 0.500 rs6088295 chr20:32344656 G/A cg22889316 chr6:5181057 LYRM4 0.54 5.97 0.31 6.31e-9 Loneliness; CRC cis rs11758351 0.660 rs113205297 chr6:26210808 A/C cg21425842 chr6:26240939 HIST1H4F -0.35 -5.76 -0.3 1.95e-8 Gout;Renal underexcretion gout; CRC cis rs9911578 0.835 rs9788975 chr17:56460800 G/A cg05425664 chr17:57184151 TRIM37 0.43 6.57 0.34 1.94e-10 Intelligence (multi-trait analysis); CRC cis rs2281845 0.929 rs6413915 chr1:201091041 A/C cg22815214 chr1:201083145 CACNA1S -0.63 -10.89 -0.51 8.38e-24 Permanent tooth development; CRC cis rs2839186 0.588 rs7280110 chr21:47619039 G/A cg13126279 chr21:47581558 C21orf56 0.38 6.09 0.32 3.22e-9 Testicular germ cell tumor; CRC cis rs1538970 0.847 rs1771550 chr1:45883565 C/T cg05343316 chr1:45956843 TESK2 -0.67 -9.23 -0.45 3.41e-18 Platelet count; CRC cis rs8105895 0.935 rs8104630 chr19:22247277 T/C cg02657401 chr19:22469223 NA -0.34 -5.65 -0.3 3.56e-8 Body mass index (change over time); CRC cis rs10504229 0.683 rs10504224 chr8:58143735 A/G cg11062466 chr8:58055876 NA 0.53 6.76 0.35 6.42e-11 Developmental language disorder (linguistic errors); CRC cis rs7666738 0.578 rs1989109 chr4:98881246 T/A cg05340658 chr4:99064831 C4orf37 0.59 8.98 0.44 2.15e-17 Colonoscopy-negative controls vs population controls; CRC cis rs7677751 0.806 rs4864863 chr4:55100831 A/G cg00691999 chr4:55094011 PDGFRA 0.41 5.76 0.3 1.89e-8 Corneal astigmatism; CRC cis rs9311474 0.569 rs7614981 chr3:52566914 G/T cg08365687 chr3:52569147 NT5DC2;LOC440957 0.36 6.04 0.32 4.28e-9 Electroencephalogram traits; CRC cis rs9916302 0.851 rs12936996 chr17:37665554 A/G cg07936489 chr17:37558343 FBXL20 0.86 13.42 0.59 4.67e-33 Glomerular filtration rate (creatinine); CRC cis rs7739232 0.920 rs75168938 chr6:53530047 C/A cg15658676 chr6:53530538 KLHL31 -0.76 -5.9 -0.31 8.9e-9 Hip circumference adjusted for BMI; CRC cis rs4253772 0.637 rs6008339 chr22:46650846 C/T cg09491104 chr22:46646882 C22orf40 -0.48 -7.51 -0.38 5.72e-13 LDL cholesterol;Cholesterol, total; CRC cis rs6089584 0.888 rs2181590 chr20:60622843 T/C cg18761221 chr20:60518478 NA 0.44 7.01 0.36 1.34e-11 Body mass index; CRC cis rs11785400 1.000 rs6997670 chr8:143737915 G/A cg24634471 chr8:143751801 JRK 0.52 7.43 0.38 9.67e-13 Schizophrenia; CRC cis rs13191362 1.000 rs13204013 chr6:163002480 T/A cg06582575 chr6:163149167 PACRG;PARK2 0.77 10.7 0.51 3.98e-23 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC trans rs7726839 0.794 rs10053310 chr5:595661 C/G cg25482853 chr8:67687455 SGK3 0.71 8.91 0.44 3.53e-17 Obesity-related traits; CRC cis rs514406 0.861 rs4926577 chr1:53226788 C/A cg08859206 chr1:53392774 SCP2 0.42 6.56 0.34 2.14e-10 Monocyte count; CRC cis rs7208859 0.623 rs7214570 chr17:29147164 A/G cg13385521 chr17:29058706 SUZ12P 0.73 8.85 0.44 5.49e-17 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs4285028 0.898 rs12491991 chr3:121706021 A/C cg11130432 chr3:121712080 ILDR1 0.5 6.66 0.34 1.15e-10 Multiple sclerosis; CRC cis rs4808199 1.000 rs17288409 chr19:19504167 T/C cg03709012 chr19:19516395 GATAD2A 1.03 12.61 0.57 5.2e-30 Nonalcoholic fatty liver disease; CRC cis rs13108904 0.870 rs12642797 chr4:1245990 G/A cg05665937 chr4:1216051 CTBP1 0.42 6.33 0.33 8.15e-10 Obesity-related traits; CRC cis rs12681288 0.523 rs6983944 chr8:955147 A/G cg08648136 chr8:956695 NA 0.35 6.8 0.35 4.84e-11 Schizophrenia; CRC cis rs9303401 0.703 rs9910629 chr17:57210301 C/G cg10487724 chr17:56770010 TEX14;RAD51C 0.47 7.17 0.37 5.01e-12 Cognitive test performance; CRC cis rs9910055 0.529 rs228748 chr17:42174390 G/A cg09913183 chr17:42254507 C17orf65;ASB16 -0.49 -6.7 -0.35 8.99e-11 Total body bone mineral density; CRC cis rs2404602 0.647 rs11072628 chr15:77107761 C/A cg23625390 chr15:77176239 SCAPER -0.85 -12.97 -0.58 2.35e-31 Blood metabolite levels; CRC cis rs9463078 0.764 rs494982 chr6:44937255 C/T cg25276700 chr6:44698697 NA -0.28 -7.08 -0.36 8.79e-12 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg19625216 chr1:249132108 ZNF672 0.44 6.32 0.33 8.65e-10 Response to antipsychotic treatment; CRC cis rs2274273 0.662 rs66476033 chr14:55660863 C/A cg10130446 chr14:55658398 DLGAP5 -0.43 -5.75 -0.3 2.08e-8 Protein biomarker; CRC trans rs7580658 0.614 rs7585198 chr2:127962635 C/T cg03490839 chr16:73082051 ZFHX3 -0.44 -6.27 -0.33 1.14e-9 Protein C levels; CRC cis rs10504229 0.683 rs35244711 chr8:58117762 T/G cg21724239 chr8:58056113 NA 0.49 6.81 0.35 4.75e-11 Developmental language disorder (linguistic errors); CRC cis rs35883536 0.647 rs10875312 chr1:101042320 G/C cg06223162 chr1:101003688 GPR88 -0.36 -6.62 -0.34 1.5e-10 Monocyte count; CRC cis rs12541335 0.590 rs11136002 chr8:22217082 C/T cg14487702 chr8:22132665 PIWIL2 0.4 5.96 0.31 6.39e-9 Hypertriglyceridemia; CRC cis rs1008375 0.966 rs3733576 chr4:17586703 T/C cg16339924 chr4:17578868 LAP3 0.69 8.87 0.44 4.68e-17 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs1511802 0.666 rs2292424 chr4:187120625 G/A cg24794857 chr4:187113578 CYP4V2 0.39 5.62 0.3 4.11e-8 Blood protein levels; CRC cis rs9381040 0.701 rs4711658 chr6:41162891 C/T cg25110423 chr6:41068646 NFYA;LOC221442 0.39 6.25 0.33 1.26e-9 Alzheimer's disease (late onset); CRC trans rs875971 0.660 rs2191268 chr7:66110224 C/T cg05446464 chr6:86387543 SNORD50B;SNHG5;SNORD50A -0.39 -6.1 -0.32 3.02e-9 Aortic root size; CRC cis rs9393777 0.513 rs6904071 chr6:27047256 G/A cg12292205 chr6:26970375 C6orf41 -0.77 -8.45 -0.42 9.35e-16 Intelligence (multi-trait analysis); CRC trans rs1728785 1.000 rs11075680 chr16:68565700 G/C cg04657470 chr2:198365150 HSPE1;HSPD1 0.57 6.78 0.35 5.72e-11 Ulcerative colitis; CRC cis rs10876993 0.928 rs1689586 chr12:58079586 A/T cg18357645 chr12:58087776 OS9 0.62 8.83 0.44 6.45e-17 Celiac disease or Rheumatoid arthritis; CRC cis rs11212617 0.967 rs227041 chr11:108222801 G/T cg14761454 chr11:108092087 ATM;NPAT 0.44 6.66 0.34 1.15e-10 Response to metformin in type 2 diabetes (glycemic); CRC cis rs9534288 0.913 rs9534299 chr13:46625586 A/T cg15192986 chr13:46630673 CPB2 -0.74 -10.26 -0.49 1.32e-21 Blood protein levels; CRC cis rs4604732 0.527 rs79329288 chr1:247626513 T/C cg12754571 chr1:247694271 LOC148824;OR2C3 0.41 5.78 0.3 1.74e-8 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CRC cis rs514406 0.861 rs1571979 chr1:53237526 G/A cg24675658 chr1:53192096 ZYG11B 0.56 8.13 0.41 8.59e-15 Monocyte count; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg26509146 chr13:80055601 NDFIP2 0.4 6.18 0.32 1.84e-9 Intelligence (multi-trait analysis); CRC cis rs9649213 0.593 rs12672092 chr7:97986557 C/A cg21770322 chr7:97807741 LMTK2 0.53 8.62 0.43 2.78e-16 Prostate cancer (SNP x SNP interaction); CRC cis rs614226 1.000 rs563920 chr12:121017439 A/G cg27489772 chr12:121021490 NA 0.5 6.81 0.35 4.54e-11 Type 1 diabetes nephropathy; CRC cis rs6500602 0.598 rs3859155 chr16:4593741 A/C cg08645402 chr16:4508243 NA -0.55 -9.45 -0.46 6.81e-19 Schizophrenia; CRC cis rs6479527 0.875 rs7858069 chr9:96769258 A/G cg14459158 chr9:96720562 NA 0.37 6.68 0.35 1.02e-10 Esophageal adenocarcinoma; CRC trans rs11098499 0.644 rs3806808 chr4:120551085 A/C cg25214090 chr10:38739885 LOC399744 0.58 9.15 0.45 5.97e-18 Corneal astigmatism; CRC cis rs11785693 0.862 rs11786595 chr8:5001621 T/G cg26367366 chr8:4980734 NA 0.69 8.35 0.42 1.98e-15 Neuroticism (multi-trait analysis);Neuroticism; CRC cis rs11098499 1.000 rs11098500 chr4:120219239 T/A cg24375607 chr4:120327624 NA 0.47 7.16 0.37 5.21e-12 Corneal astigmatism; CRC cis rs9818758 0.556 rs9880309 chr3:49304329 G/C cg00383909 chr3:49044727 WDR6 1.1 10.48 0.5 2.33e-22 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; CRC trans rs7580658 0.614 rs7585198 chr2:127962635 C/T cg11483887 chr15:78441560 IDH3A -0.46 -6.34 -0.33 7.65e-10 Protein C levels; CRC cis rs1005277 0.522 rs289649 chr10:37975384 T/C cg25517755 chr10:38738941 LOC399744 -0.42 -6.01 -0.31 5.01e-9 Extrinsic epigenetic age acceleration; CRC cis rs9322817 0.902 rs9404576 chr6:105184640 T/G cg02098413 chr6:105308735 HACE1 -0.36 -6.65 -0.34 1.2e-10 Thyroid stimulating hormone; CRC trans rs3733585 0.673 rs4314284 chr4:9956096 C/T cg26043149 chr18:55253948 FECH -0.49 -7.56 -0.38 4.02e-13 Cleft plate (environmental tobacco smoke interaction); CRC cis rs10504229 0.679 rs17801003 chr8:58050930 A/G cg11062466 chr8:58055876 NA 0.55 6.98 0.36 1.67e-11 Developmental language disorder (linguistic errors); CRC cis rs10751667 0.961 rs6421967 chr11:983966 T/C cg01483505 chr11:975446 AP2A2 0.39 5.92 0.31 7.91e-9 Alzheimer's disease (late onset); CRC cis rs11785693 0.862 rs11786186 chr8:4999059 G/C cg26367366 chr8:4980734 NA 0.79 9.74 0.47 7.33e-20 Neuroticism (multi-trait analysis);Neuroticism; CRC cis rs9640161 0.830 rs3757425 chr7:150067640 A/C cg13722127 chr7:150037890 RARRES2 0.36 5.84 0.31 1.28e-8 Blood protein levels;Circulating chemerin levels; CRC cis rs7119 0.717 rs8040702 chr15:77803615 G/A cg10437265 chr15:77819839 NA 0.67 11.85 0.55 3.34e-27 Type 2 diabetes; CRC cis rs6599388 0.803 rs11248057 chr4:906131 C/G cg15105011 chr4:940614 TMEM175 -0.39 -5.82 -0.31 1.41e-8 Parkinson's disease; CRC cis rs2153535 0.601 rs9505472 chr6:8538765 T/C cg21535247 chr6:8435926 SLC35B3 0.51 7.81 0.4 7.77e-14 Motion sickness; CRC cis rs875971 0.862 rs13226170 chr7:65999298 G/A cg18876405 chr7:65276391 NA 0.52 8.37 0.42 1.64e-15 Aortic root size; CRC cis rs3733585 0.673 rs4467564 chr4:9953472 G/T cg11266682 chr4:10021025 SLC2A9 -0.47 -9.62 -0.47 1.76e-19 Cleft plate (environmental tobacco smoke interaction); CRC trans rs6076960 0.684 rs3852949 chr20:6264758 T/A cg24759859 chr6:86352639 SYNCRIP 0.48 6.67 0.35 1.1e-10 Smooth-surface caries; CRC cis rs965469 0.895 rs6051841 chr20:3392871 A/G cg25506879 chr20:3388711 C20orf194 -0.41 -6.08 -0.32 3.24e-9 IFN-related cytopenia; CRC cis rs4481887 0.720 rs4543835 chr1:248468608 A/T cg13385794 chr1:248469461 NA 0.4 7.05 0.36 1.03e-11 Common traits (Other); CRC trans rs11039798 0.512 rs1988465 chr11:49011303 C/T cg15704280 chr7:45808275 SEPT13 0.65 6.47 0.34 3.57e-10 Axial length; CRC cis rs4481887 1.000 rs4481887 chr1:248496863 A/G cg13385794 chr1:248469461 NA 0.39 6.68 0.35 9.97e-11 Common traits (Other); CRC cis rs8014204 0.762 rs7144654 chr14:75298637 A/G cg03030879 chr14:75389066 RPS6KL1 -0.41 -6.54 -0.34 2.3e-10 Caffeine consumption; CRC cis rs28386778 0.897 rs2584608 chr17:61936710 A/G cg22520471 chr17:61851767 DDX42;CCDC47 0.73 11.22 0.53 6.03e-25 Prudent dietary pattern; CRC cis rs3858526 0.584 rs10769276 chr11:5868020 G/T cg25319279 chr11:5960081 NA -0.37 -5.73 -0.3 2.24e-8 DNA methylation (variation); CRC trans rs11098499 0.908 rs1002152 chr4:120273387 C/A cg25214090 chr10:38739885 LOC399744 0.61 9.47 0.46 5.8e-19 Corneal astigmatism; CRC cis rs4819052 0.807 rs28715237 chr21:46673768 C/G cg19498844 chr21:46707878 POFUT2;LOC642852 0.78 11.28 0.53 3.77e-25 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs9322193 0.923 rs9968911 chr6:149978555 A/T cg07701084 chr6:150067640 NUP43 0.55 7.99 0.4 2.36e-14 Lung cancer; CRC cis rs11105298 0.891 rs10506972 chr12:89861529 T/C cg00757033 chr12:89920650 WDR51B 0.37 6.13 0.32 2.52e-9 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; CRC cis rs6496667 0.821 rs13329289 chr15:90897454 C/T cg04176472 chr15:90893244 GABARAPL3 0.52 7.95 0.4 3.04e-14 Rheumatoid arthritis; CRC cis rs800160 0.777 rs2651779 chr11:2344270 G/A cg09785033 chr11:2336066 TSPAN32 -0.47 -5.61 -0.3 4.31e-8 Bacteremia; CRC cis rs9649213 0.593 rs3801256 chr7:97992095 C/G cg00277769 chr7:97922759 BAIAP2L1 -0.6 -10.53 -0.5 1.59e-22 Prostate cancer (SNP x SNP interaction); CRC cis rs394563 0.591 rs805026 chr6:149728254 G/C cg03678062 chr6:149772716 ZC3H12D -0.35 -6.36 -0.33 6.68e-10 Dupuytren's disease; CRC trans rs58688157 0.705 rs11539530 chr11:609353 G/A cg19188899 chr13:112838565 NA -0.43 -6.69 -0.35 9.72e-11 Systemic lupus erythematosus; CRC cis rs9486719 1.000 rs12208124 chr6:97027942 C/T cg18709589 chr6:96969512 KIAA0776 -0.52 -5.85 -0.31 1.21e-8 Migraine;Coronary artery disease; CRC cis rs12135894 0.648 rs4648423 chr1:3765678 C/T cg13057898 chr1:3703894 LRRC47 -0.41 -5.82 -0.31 1.37e-8 Mean corpuscular volume; CRC cis rs2354432 0.607 rs11239980 chr1:146782698 G/A cg25205988 chr1:146714368 CHD1L -1.13 -9.43 -0.46 7.38e-19 Mitochondrial DNA levels; CRC cis rs7632954 0.935 rs7619333 chr3:8530583 G/A cg03495237 chr3:8533978 NA 0.34 5.64 0.3 3.57e-8 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs9399135 0.935 rs987690 chr6:135350379 A/G cg24558204 chr6:135376177 HBS1L 0.51 8.06 0.41 1.41e-14 Red blood cell count; CRC cis rs6564219 1 rs6564219 chr16:75222006 G/C cg09066997 chr16:75300724 BCAR1 0.64 6.0 0.31 5.09e-9 Alcoholic chronic pancreatitis; CRC cis rs4073582 0.595 rs801737 chr11:65928193 T/C cg16950941 chr11:66035639 RAB1B 0.69 12.15 0.56 2.61e-28 Gout; CRC cis rs1005277 0.579 rs9299760 chr10:38377920 C/T cg25427524 chr10:38739819 LOC399744 -0.76 -13.55 -0.6 1.57e-33 Extrinsic epigenetic age acceleration; CRC cis rs6429082 0.818 rs291383 chr1:235643100 G/A cg26050004 chr1:235667680 B3GALNT2 0.58 7.96 0.4 2.87e-14 Adiposity; CRC cis rs6964587 0.692 rs17672805 chr7:91573466 A/G cg17063962 chr7:91808500 NA -0.62 -9.92 -0.48 1.77e-20 Breast cancer; CRC cis rs9322193 0.886 rs2065663 chr6:150081467 A/G cg05861140 chr6:150128134 PCMT1 -0.4 -6.26 -0.33 1.2e-9 Lung cancer; CRC cis rs2739330 0.731 rs2000468 chr22:24241611 G/T cg24846343 chr22:24311635 DDTL 0.73 12.12 0.56 3.29e-28 Liver enzyme levels (gamma-glutamyl transferase); CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg15138986 chr10:131935156 GLRX3 -0.41 -6.02 -0.31 4.75e-9 Myopia (pathological); CRC cis rs863345 0.604 rs10908670 chr1:158502113 T/C cg12129480 chr1:158549410 OR10X1 -0.3 -6.27 -0.33 1.12e-9 Pneumococcal bacteremia; CRC cis rs1799949 1.000 rs11654731 chr17:41326940 G/A cg25072359 chr17:41440525 NA 0.43 6.36 0.33 6.77e-10 Menopause (age at onset); CRC cis rs1375194 0.582 rs13391166 chr2:33805314 C/T cg04131969 chr2:33951647 MYADML 0.49 7.14 0.37 6.15e-12 Response to antidepressants in depression; CRC cis rs11628318 0.614 rs1190342 chr14:103100382 C/T cg12046867 chr14:103022105 NA -0.77 -9.19 -0.45 4.59e-18 Platelet count; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg01237565 chr14:105715025 BRF1;BTBD6 0.51 7.19 0.37 4.43e-12 Anxiety disorder; CRC cis rs2404602 0.536 rs17364330 chr15:76765385 A/T cg03037974 chr15:76606532 NA 0.64 11.16 0.52 9.32e-25 Blood metabolite levels; CRC cis rs796364 0.813 rs7565417 chr2:201057491 G/A cg25936922 chr2:200820526 C2orf60;C2orf47 0.57 6.36 0.33 6.83e-10 Schizophrenia; CRC cis rs11690935 0.959 rs7562356 chr2:172626611 C/G cg13550731 chr2:172543902 DYNC1I2 -1.07 -17.98 -0.7 7.79e-51 Schizophrenia; CRC cis rs35264875 0.898 rs55648928 chr11:68861591 G/T cg03469862 chr11:68924853 NA 0.47 6.03 0.32 4.33e-9 Blond vs. brown hair color; CRC cis rs7208859 0.673 rs9898858 chr17:29156211 A/T cg01831904 chr17:28903510 LRRC37B2 -0.61 -6.43 -0.33 4.58e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs4862750 0.832 rs6836426 chr4:187897837 T/G cg22105103 chr4:187893119 NA 0.63 11.46 0.53 8.46e-26 Lobe attachment (rater-scored or self-reported); CRC cis rs1862618 0.853 rs832551 chr5:56180112 T/G cg22800045 chr5:56110881 MAP3K1 0.62 6.64 0.34 1.29e-10 Initial pursuit acceleration; CRC cis rs9487051 0.872 rs9386793 chr6:109610002 C/A cg01475377 chr6:109611718 NA -0.49 -9.21 -0.45 3.82e-18 Reticulocyte fraction of red cells; CRC cis rs10089 1.000 rs1559263 chr5:127512873 A/C cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.69 9.22 0.45 3.55e-18 Ileal carcinoids; CRC cis rs6502050 0.835 rs12051747 chr17:80114814 T/C cg11859384 chr17:80120422 CCDC57 -0.38 -6.02 -0.31 4.78e-9 Life satisfaction; CRC cis rs2455601 0.638 rs2568092 chr11:8987438 A/G cg09997546 chr11:8931473 C11orf17;ST5 0.42 6.0 0.31 5.34e-9 Schizophrenia; CRC cis rs9463078 0.753 rs636845 chr6:44935341 C/T cg25276700 chr6:44698697 NA -0.28 -7.05 -0.36 1.06e-11 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; CRC cis rs972578 1.000 rs2267482 chr22:43380548 G/C cg01576275 chr22:43409880 NA -0.46 -7.28 -0.37 2.52e-12 Mean platelet volume; CRC cis rs6570726 0.791 rs621382 chr6:145799144 T/C cg05347473 chr6:146136440 FBXO30 0.38 5.8 0.3 1.53e-8 Lobe attachment (rater-scored or self-reported); CRC cis rs2227564 0.729 rs2633306 chr10:75652447 G/T cg00564723 chr10:75632066 CAMK2G 0.33 7.77 0.39 1.01e-13 Crohn's disease;Inflammatory bowel disease; CRC cis rs9522267 0.535 rs9522290 chr13:112233130 A/G cg10483660 chr13:112241077 NA -0.48 -8.98 -0.44 2.09e-17 Hepatitis; CRC cis rs2073300 0.609 rs77908916 chr20:23405626 C/G cg12062639 chr20:23401060 NAPB 0.84 7.64 0.39 2.34e-13 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs2569991 0.636 rs361221 chr3:12922767 A/C cg22481960 chr3:13008800 IQSEC1 0.49 6.33 0.33 8.16e-10 Periodontitis (DPAL); CRC cis rs9296092 0.517 rs113111213 chr6:33520790 A/G cg13560919 chr6:33536144 NA -0.43 -6.17 -0.32 2.04e-9 Age at smoking initiation in chronic obstructive pulmonary disease; CRC cis rs6761276 0.649 rs3811055 chr2:113831182 A/T cg09040174 chr2:113837401 NA 0.43 5.79 0.3 1.64e-8 Protein quantitative trait loci; CRC cis rs7666738 0.791 rs7660866 chr4:98961335 G/A cg05340658 chr4:99064831 C4orf37 0.61 9.45 0.46 6.55e-19 Colonoscopy-negative controls vs population controls; CRC cis rs290268 1.000 rs290268 chr9:93552450 A/G cg02608019 chr9:93564028 SYK 0.47 7.46 0.38 7.64e-13 Platelet count; CRC cis rs11190604 1.000 rs11190557 chr10:102209369 G/A cg07080220 chr10:102295463 HIF1AN 0.47 5.82 0.31 1.38e-8 Palmitoleic acid (16:1n-7) levels; CRC cis rs6484504 0.532 rs11031332 chr11:31278962 T/C cg14844989 chr11:31128820 NA -0.34 -5.96 -0.31 6.62e-9 Red blood cell count; CRC trans rs1005277 0.557 rs176887 chr10:38406094 T/C cg11292332 chr7:45801988 SEPT13 -0.35 -6.25 -0.33 1.24e-9 Extrinsic epigenetic age acceleration; CRC cis rs911555 0.574 rs34251103 chr14:103860063 A/G cg24130564 chr14:104152367 KLC1 0.42 5.67 0.3 3.08e-8 Intelligence (multi-trait analysis); CRC cis rs4664293 0.934 rs4380179 chr2:160541575 G/T cg08347373 chr2:160653686 CD302 -0.38 -6.19 -0.32 1.83e-9 Monocyte percentage of white cells; CRC cis rs6952808 0.895 rs4513875 chr7:1928159 C/T cg22963979 chr7:1858916 MAD1L1 -0.5 -7.45 -0.38 8.09e-13 Bipolar disorder and schizophrenia; CRC cis rs4363385 0.747 rs4845332 chr1:152982632 C/T cg25856811 chr1:152973957 SPRR3 -0.25 -6.85 -0.35 3.56e-11 Inflammatory skin disease; CRC cis rs425277 0.628 rs3107147 chr1:2048729 G/A cg19257562 chr1:2043853 PRKCZ 0.4 6.62 0.34 1.46e-10 Height; CRC cis rs7809950 0.861 rs2701682 chr7:107295835 G/A cg23024343 chr7:107201750 COG5 0.7 9.37 0.46 1.2e-18 Coronary artery disease; CRC cis rs13108904 0.840 rs3915420 chr4:1260337 T/C cg16405210 chr4:1374714 KIAA1530 -0.42 -5.85 -0.31 1.17e-8 Obesity-related traits; CRC cis rs897984 0.683 rs12926237 chr16:30837596 C/T cg02466173 chr16:30829666 NA 0.79 13.58 0.6 1.21e-33 Dementia with Lewy bodies; CRC cis rs55871839 0.684 rs10095333 chr8:59815629 G/A cg07426533 chr8:59803705 TOX -0.34 -5.86 -0.31 1.15e-8 Pneumonia; CRC cis rs801193 0.569 rs4717315 chr7:66178325 C/T cg11764359 chr7:65958608 NA 0.59 8.8 0.44 7.87e-17 Aortic root size; CRC cis rs17739167 0.550 rs11634233 chr15:42224563 G/A cg20935245 chr15:42234343 EHD4 0.41 6.46 0.34 3.85e-10 Monocyte count; CRC cis rs17666538 0.585 rs1669733 chr8:606696 C/T cg26554054 chr8:600488 NA -0.61 -5.93 -0.31 7.61e-9 IgG glycosylation; CRC cis rs7618501 0.602 rs2526754 chr3:50125996 G/A cg24110177 chr3:50126178 RBM5 0.52 8.22 0.41 4.72e-15 Intelligence (multi-trait analysis); CRC cis rs1997103 1.000 rs6593237 chr7:55411015 T/C cg17469321 chr7:55412551 NA 0.71 11.15 0.52 1.09e-24 QRS interval (sulfonylurea treatment interaction); CRC cis rs9467773 1.000 rs1321481 chr6:26538210 A/T cg09904177 chr6:26538194 HMGN4 0.86 14.87 0.63 1.27e-38 Intelligence (multi-trait analysis); CRC cis rs6502050 0.835 rs12600852 chr17:80104593 G/A cg13198984 chr17:80129470 CCDC57 0.46 8.16 0.41 6.94e-15 Life satisfaction; CRC cis rs231513 0.954 rs231500 chr17:41973374 T/C cg26893861 chr17:41843967 DUSP3 -0.62 -6.37 -0.33 6.48e-10 Cognitive function; CRC trans rs57221529 0.766 rs72703042 chr5:579269 C/T cg25482853 chr8:67687455 SGK3 1.25 14.99 0.64 4.45e-39 Lung disease severity in cystic fibrosis; CRC cis rs951366 0.668 rs823154 chr1:205762406 C/T cg07157834 chr1:205819609 PM20D1 0.86 13.89 0.61 8.04e-35 Menarche (age at onset); CRC cis rs3540 0.960 rs1505936 chr15:91010776 T/C cg22089800 chr15:90895588 ZNF774 0.5 7.97 0.4 2.67e-14 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; CRC cis rs4631830 0.720 rs2012677 chr10:51504797 T/A cg20129853 chr10:51489980 NA -0.41 -6.93 -0.36 2.2e-11 Prostate-specific antigen levels; CRC cis rs950169 0.545 rs4354897 chr15:84644971 T/C cg17507749 chr15:85114479 UBE2QP1 0.64 8.53 0.43 5.53e-16 Schizophrenia; CRC cis rs7246657 0.943 rs9676967 chr19:37928089 G/C cg23950597 chr19:37808831 NA -0.49 -6.09 -0.32 3.18e-9 Coronary artery calcification; CRC cis rs2066819 1.000 rs74673257 chr12:56638077 T/C cg26714650 chr12:56694279 CS -1.41 -11.64 -0.54 1.88e-26 Psoriasis vulgaris; CRC cis rs1218582 0.710 rs9793588 chr1:154878878 C/G cg06221963 chr1:154839813 KCNN3 -0.76 -15.27 -0.64 3.58e-40 Prostate cancer; CRC cis rs2204008 0.560 rs1315354 chr12:38165716 A/G cg26384229 chr12:38710491 ALG10B -0.57 -8.42 -0.42 1.21e-15 Bladder cancer; CRC cis rs11758351 1.000 rs79868973 chr6:26189312 C/G cg10723962 chr6:26240782 HIST1H4F -0.36 -5.75 -0.3 2.06e-8 Gout;Renal underexcretion gout; CRC trans rs12517041 1.000 rs2081953 chr5:23295682 G/A ch.8.1293020R chr8:59333349 UBXN2B -0.55 -6.17 -0.32 2.05e-9 Calcium levels; CRC cis rs908922 0.676 rs11205032 chr1:152527690 A/G cg23254163 chr1:152506842 NA 0.49 9.71 0.47 8.9e-20 Hair morphology; CRC cis rs6429082 0.755 rs291371 chr1:235693105 C/G cg26050004 chr1:235667680 B3GALNT2 0.57 8.43 0.42 1.13e-15 Adiposity; CRC cis rs367615 0.704 rs72804385 chr5:108848143 T/C cg17395555 chr5:108820864 NA 0.44 8.79 0.44 8.75e-17 Colorectal cancer (SNP x SNP interaction); CRC cis rs4664293 0.836 rs11687502 chr2:160616975 T/G cg08347373 chr2:160653686 CD302 -0.47 -7.43 -0.38 9.32e-13 Monocyte percentage of white cells; CRC cis rs4481887 1.000 rs11204636 chr1:248492409 A/C cg00666640 chr1:248458726 OR2T12 -0.52 -8.69 -0.43 1.76e-16 Common traits (Other); CRC cis rs6066835 0.764 rs28741053 chr20:47378114 T/C cg18078177 chr20:47281410 PREX1 0.67 5.7 0.3 2.62e-8 Multiple myeloma; CRC cis rs4713118 0.869 rs9348775 chr6:27695329 C/T cg20933634 chr6:27740509 NA 0.59 8.6 0.43 3.36e-16 Parkinson's disease; CRC trans rs7615952 0.551 rs6438945 chr3:125634473 G/A cg07211511 chr3:129823064 LOC729375 -1.19 -18.29 -0.71 4.51e-52 Blood pressure (smoking interaction); CRC cis rs73206853 0.563 rs80044246 chr12:111133535 C/A cg12870014 chr12:110450643 ANKRD13A 0.8 9.08 0.45 1.04e-17 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC cis rs4654899 0.965 rs10753513 chr1:21492168 T/C cg02927042 chr1:21476669 EIF4G3 0.45 7.22 0.37 3.56e-12 Superior frontal gyrus grey matter volume; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg13645902 chr11:118661758 DDX6 0.4 6.18 0.32 1.88e-9 Liver disease severity in Alagille syndrome; CRC cis rs77972916 0.536 rs11694173 chr2:43590899 A/G cg06169590 chr2:43455088 ZFP36L2;LOC100129726 0.51 5.89 0.31 9.74e-9 Granulocyte percentage of myeloid white cells; CRC cis rs1218582 0.774 rs4845681 chr1:154868055 G/T cg03351412 chr1:154909251 PMVK 0.5 7.92 0.4 3.68e-14 Prostate cancer; CRC cis rs736408 0.570 rs11130327 chr3:52793239 A/G cg05573699 chr3:52720067 GNL3;PBRM1 -0.45 -6.3 -0.33 9.64e-10 Bipolar disorder; CRC cis rs2952156 0.920 rs9675194 chr17:37833805 A/G cg00129232 chr17:37814104 STARD3 -0.66 -11.29 -0.53 3.22e-25 Asthma; CRC cis rs62244186 0.715 rs13321717 chr3:44667455 C/A cg15687855 chr3:44754131 ZNF502 -0.34 -5.66 -0.3 3.3e-8 Depressive symptoms; CRC cis rs1728785 0.901 rs1170444 chr16:68573287 T/C cg02972257 chr16:68554789 NA -0.57 -6.92 -0.36 2.41e-11 Ulcerative colitis; CRC cis rs1499614 1.000 rs1638731 chr7:66144679 C/T cg25985355 chr7:65971099 NA -0.52 -5.95 -0.31 6.88e-9 Gout; CRC cis rs10504229 1.000 rs59797486 chr8:58174435 T/C cg02725872 chr8:58115012 NA -0.32 -5.63 -0.3 3.94e-8 Developmental language disorder (linguistic errors); CRC cis rs9467711 0.606 rs34273322 chr6:26415409 T/A cg14345882 chr6:26364793 BTN3A2 0.7 5.75 0.3 2.03e-8 Autism spectrum disorder or schizophrenia; CRC cis rs11212617 1.000 rs186593 chr11:108262439 G/A cg01991180 chr11:108092276 ATM;NPAT 0.43 6.34 0.33 7.41e-10 Response to metformin in type 2 diabetes (glycemic); CRC cis rs847577 0.630 rs3801294 chr7:97822210 G/A cg24562669 chr7:97807699 LMTK2 0.79 17.64 0.7 1.72e-49 Breast cancer; CRC trans rs4586057 0.812 rs11186341 chr10:92623448 G/C cg26894278 chr13:21016241 CRYL1 0.36 6.04 0.32 4.13e-9 Economic and political preferences (time); CRC cis rs701145 0.556 rs355762 chr3:154012614 G/A cg16511985 chr3:153974050 SGEF 0.43 5.65 0.3 3.53e-8 Coronary artery disease; CRC cis rs1538970 0.924 rs4660855 chr1:45899795 A/G cg05343316 chr1:45956843 TESK2 0.74 10.05 0.48 6.51e-21 Platelet count; CRC cis rs2075671 0.857 rs11772849 chr7:100308412 G/A cg20848291 chr7:100343083 ZAN -0.66 -10.02 -0.48 8.71e-21 Other erythrocyte phenotypes; CRC cis rs17401966 1.000 rs17401924 chr1:10384439 A/G cg19773385 chr1:10388646 KIF1B -0.58 -8.02 -0.4 1.83e-14 Hepatocellular carcinoma; CRC cis rs1799949 0.965 rs6503726 chr17:41284742 T/C cg05368731 chr17:41323189 NBR1 0.57 8.47 0.42 8.23e-16 Menopause (age at onset); CRC cis rs2228479 0.850 rs62054611 chr16:89817017 T/C cg06558623 chr16:89946397 TCF25 1.15 10.8 0.51 1.85e-23 Skin colour saturation; CRC cis rs694739 0.796 rs479777 chr11:64107477 A/G cg02228329 chr11:64053129 BAD;GPR137 0.56 8.39 0.42 1.41e-15 Alopecia areata;Crohn's disease;Psoriasis vulgaris; CRC cis rs72781680 0.846 rs55770503 chr2:24030126 A/T cg08917208 chr2:24149416 ATAD2B 0.87 8.62 0.43 2.84e-16 Lymphocyte counts; CRC cis rs7615952 0.576 rs4646763 chr3:125822129 G/A cg02772935 chr3:125709198 NA -0.49 -5.71 -0.3 2.46e-8 Blood pressure (smoking interaction); CRC cis rs6499255 0.951 rs3743673 chr16:69711311 A/T cg04110750 chr16:69646130 NFAT5 -0.58 -7.93 -0.4 3.35e-14 IgE levels; CRC cis rs3751196 0.901 rs17794246 chr12:104177338 A/G cg02344784 chr12:104178138 NT5DC3 -0.67 -7.31 -0.37 2.09e-12 Sense of smell; CRC cis rs13315871 0.929 rs9811074 chr3:58421846 A/G cg20936604 chr3:58311152 NA -0.76 -7.15 -0.37 5.74e-12 Cholesterol, total; CRC cis rs4731207 0.564 rs12531311 chr7:124625546 A/G cg23710748 chr7:124431027 NA -0.39 -6.25 -0.33 1.29e-9 Cutaneous malignant melanoma; CRC cis rs2976388 0.590 rs10087426 chr8:143814554 G/A cg20041105 chr8:143859282 LYNX1 -0.41 -6.87 -0.35 3.15e-11 Urinary tract infection frequency; CRC cis rs731174 0.759 rs591567 chr1:38149847 A/G cg06917450 chr1:38156652 C1orf109 -0.51 -7.18 -0.37 4.74e-12 Prostate cancer (SNP x SNP interaction); CRC cis rs936229 0.954 rs936230 chr15:75145098 C/T cg14664628 chr15:75095509 CSK 0.87 16.08 0.66 2.45e-43 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); CRC cis rs2404602 0.967 rs2083762 chr15:76907376 T/C cg22467129 chr15:76604101 ETFA -0.4 -6.65 -0.34 1.19e-10 Blood metabolite levels; CRC cis rs9992667 0.577 rs10021686 chr4:38705257 C/T cg19726192 chr4:38663646 FLJ13197 -0.59 -6.72 -0.35 8.08e-11 Eosinophil percentage of granulocytes; CRC cis rs514406 0.792 rs1242201 chr1:53344748 G/A cg24675658 chr1:53192096 ZYG11B -0.61 -9.04 -0.45 1.42e-17 Monocyte count; CRC cis rs4727027 0.800 rs10952796 chr7:148813138 G/C cg23583168 chr7:148888333 NA -0.83 -13.38 -0.59 6.55e-33 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC cis rs6496667 0.779 rs8024110 chr15:90947453 A/G cg04176472 chr15:90893244 GABARAPL3 -0.53 -7.49 -0.38 6.36e-13 Rheumatoid arthritis; CRC cis rs9649213 0.613 rs10953256 chr7:97951886 G/C cg24562669 chr7:97807699 LMTK2 0.42 7.04 0.36 1.1e-11 Prostate cancer (SNP x SNP interaction); CRC cis rs769267 0.965 rs2269873 chr19:19392401 T/C cg01262667 chr19:19385393 TM6SF2 0.36 5.87 0.31 1.06e-8 Tonsillectomy; CRC cis rs1814175 0.529 rs10839396 chr11:49852406 G/T cg02254774 chr11:50257496 LOC441601 0.47 6.52 0.34 2.69e-10 Height; CRC cis rs4664293 0.867 rs12692564 chr2:160617837 G/A cg08347373 chr2:160653686 CD302 -0.47 -7.43 -0.38 9.32e-13 Monocyte percentage of white cells; CRC cis rs7412746 0.634 rs3754212 chr1:150738200 A/G cg18016565 chr1:150552671 MCL1 0.44 6.06 0.32 3.76e-9 Melanoma; CRC cis rs2976388 0.578 rs34956412 chr8:143822028 C/T cg20041105 chr8:143859282 LYNX1 -0.41 -6.48 -0.34 3.38e-10 Urinary tract infection frequency; CRC cis rs6424115 0.760 rs2999566 chr1:24051124 A/G cg15997130 chr1:24165203 NA 0.7 10.36 0.5 5.81e-22 Immature fraction of reticulocytes; CRC cis rs877282 0.838 rs34912955 chr10:772222 T/C cg06581033 chr10:766294 NA -0.5 -5.76 -0.3 1.93e-8 Uric acid levels; CRC cis rs17209837 0.646 rs11532733 chr7:87117982 A/G cg00919237 chr7:87102261 ABCB4 -0.51 -6.43 -0.33 4.5e-10 Gallbladder cancer; CRC cis rs7954584 0.505 rs11043278 chr12:122412145 C/T cg21171335 chr12:122356390 WDR66 0.39 5.91 0.31 8.61e-9 Mean corpuscular volume; CRC cis rs7493 1.000 rs17876123 chr7:95045307 C/A cg19678392 chr7:94953810 PON1 -0.59 -7.36 -0.38 1.49e-12 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs1552244 1.000 rs6442146 chr3:10073544 C/T cg16606324 chr3:10149918 C3orf24 0.69 9.58 0.47 2.55e-19 Alzheimer's disease; CRC cis rs172166 0.516 rs1150670 chr6:28130559 A/G cg10876282 chr6:28092338 ZSCAN16 0.4 5.7 0.3 2.67e-8 Cardiac Troponin-T levels; CRC cis rs77861329 0.748 rs749995 chr3:52176701 C/T cg08692210 chr3:52188851 WDR51A 0.5 5.89 0.31 9.43e-9 Macrophage inflammatory protein 1b levels; CRC cis rs898097 0.607 rs2199111 chr17:80823203 A/G cg15664640 chr17:80829946 TBCD -0.44 -7.3 -0.37 2.23e-12 Breast cancer; CRC cis rs7264396 0.563 rs2425121 chr20:34326186 A/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.49 -6.55 -0.34 2.15e-10 Total cholesterol levels; CRC cis rs910316 0.763 rs175490 chr14:75545685 A/G cg08847533 chr14:75593920 NEK9 0.86 15.19 0.64 7.39e-40 Height; CRC cis rs9768139 0.634 rs56389048 chr7:158121368 T/A cg06219351 chr7:158114137 PTPRN2 -0.54 -8.21 -0.41 5.24e-15 Calcium levels; CRC cis rs2288073 1.000 rs2288073 chr2:24413298 C/T cg06627628 chr2:24431161 ITSN2 0.65 9.16 0.45 5.67e-18 Venous thromboembolism (SNP x SNP interaction); CRC cis rs1005277 0.505 rs7069702 chr10:38247359 G/T cg25517755 chr10:38738941 LOC399744 0.45 6.56 0.34 2.07e-10 Extrinsic epigenetic age acceleration; CRC cis rs7412746 0.646 rs1972060 chr1:150937594 T/C cg15448220 chr1:150897856 SETDB1 0.47 6.99 0.36 1.58e-11 Melanoma; CRC cis rs2072510 0.569 rs61937881 chr12:96393587 C/T cg09636302 chr12:96389483 HAL -0.53 -6.49 -0.34 3.1e-10 Metabolite levels (small molecules and protein measures); CRC cis rs7659604 0.605 rs1396080 chr4:122740454 T/G cg06713675 chr4:122721982 EXOSC9 -0.41 -6.69 -0.35 9.71e-11 Type 2 diabetes; CRC cis rs561341 0.882 rs2428337 chr17:30299467 C/T cg19193384 chr17:30244184 NA -0.65 -7.5 -0.38 6.17e-13 Hip circumference adjusted for BMI; CRC cis rs2180341 1.000 rs2144742 chr6:127595786 C/A cg24812749 chr6:127587940 RNF146 0.94 13.67 0.6 5.36e-34 Breast cancer; CRC trans rs61931739 0.500 rs11053260 chr12:34530215 T/G cg26384229 chr12:38710491 ALG10B 0.59 8.77 0.44 9.64e-17 Morning vs. evening chronotype; CRC cis rs2635047 0.713 rs17723389 chr18:44762307 C/T cg19077165 chr18:44547161 KATNAL2 -0.41 -6.03 -0.32 4.41e-9 Educational attainment; CRC trans rs7395662 0.500 rs1605360 chr11:48685714 G/A cg03929089 chr4:120376271 NA -0.49 -7.05 -0.36 1.03e-11 HDL cholesterol; CRC cis rs1005277 0.579 rs1740749 chr10:38521646 A/G cg25427524 chr10:38739819 LOC399744 -0.79 -14.49 -0.62 3.78e-37 Extrinsic epigenetic age acceleration; CRC trans rs2045966 0.881 rs508052 chr8:98524688 C/T cg07320695 chr4:107423690 NA 0.52 6.22 0.32 1.54e-9 nicotine metabolite ratio in current smokers; CRC cis rs344364 0.511 rs1657132 chr16:1949924 C/T cg03013636 chr16:1946785 NA 0.59 7.16 0.37 5.31e-12 Glomerular filtration rate in chronic kidney disease; CRC cis rs17711722 0.675 rs6947132 chr7:65273495 G/A cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.48 -7.1 -0.36 7.87e-12 Calcium levels; CRC cis rs4888262 0.545 rs7193959 chr16:74664969 T/A cg01733217 chr16:74700730 RFWD3 0.83 12.71 0.57 2.22e-30 Testicular germ cell tumor; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg18076766 chr12:102455961 CCDC53 0.43 5.96 0.31 6.39e-9 Response to antipsychotic treatment; CRC cis rs6952808 0.531 rs3779003 chr7:2184902 C/T cg22963979 chr7:1858916 MAD1L1 -0.4 -5.86 -0.31 1.12e-8 Bipolar disorder and schizophrenia; CRC cis rs6762 0.642 rs28692469 chr11:839675 T/C cg07691484 chr11:842764 TSPAN4;POLR2L -0.56 -8.33 -0.42 2.21e-15 Mean platelet volume; CRC cis rs4727027 0.901 rs4727017 chr7:148822062 A/G cg12479418 chr7:148823350 ZNF425;ZNF398 0.44 5.88 0.31 1e-8 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC cis rs7937682 0.889 rs10749984 chr11:111492861 T/C cg09085632 chr11:111637200 PPP2R1B -0.98 -19.21 -0.73 1.09e-55 Primary sclerosing cholangitis; CRC cis rs9389248 0.690 rs2294321 chr6:135253048 T/G cg22676075 chr6:135203613 NA -0.65 -10.08 -0.49 5.16e-21 High light scatter reticulocyte percentage of red cells; CRC cis rs861020 0.606 rs657844 chr1:210006873 T/G cg09163369 chr1:210001066 C1orf107 0.41 5.78 0.3 1.77e-8 Orofacial clefts; CRC cis rs6502050 0.835 rs6502079 chr17:80124454 T/A cg13198984 chr17:80129470 CCDC57 0.47 8.35 0.42 1.88e-15 Life satisfaction; CRC cis rs4722166 0.532 rs6963866 chr7:22757341 C/T cg05472934 chr7:22766657 IL6 0.64 9.93 0.48 1.76e-20 Lung cancer; CRC cis rs4713118 0.955 rs9380012 chr6:27684654 A/G cg15845792 chr6:28175446 NA 0.6 7.95 0.4 3.01e-14 Parkinson's disease; CRC cis rs35306767 0.903 rs11253462 chr10:889323 T/G cg26597838 chr10:835615 NA 0.88 10.85 0.51 1.2e-23 Eosinophil percentage of granulocytes; CRC cis rs35146811 0.700 rs4729579 chr7:99780282 C/G cg13334819 chr7:99746414 C7orf59 -0.51 -6.72 -0.35 7.79e-11 Coronary artery disease; CRC cis rs950169 0.579 rs12913054 chr15:84664456 A/G cg17507749 chr15:85114479 UBE2QP1 0.64 8.64 0.43 2.56e-16 Schizophrenia; CRC cis rs17666538 0.585 rs1669733 chr8:606696 C/T cg13264159 chr8:625131 ERICH1 0.77 7.39 0.38 1.24e-12 IgG glycosylation; CRC cis rs2228479 0.618 rs34689166 chr16:89860697 C/T cg06558623 chr16:89946397 TCF25 1.18 11.57 0.54 3.24e-26 Skin colour saturation; CRC cis rs79057730 0.527 rs35316052 chr7:802954 C/T cg11064039 chr7:766100 PRKAR1B;HEATR2 0.69 6.74 0.35 7.28e-11 Initial pursuit acceleration; CRC cis rs1005277 0.522 rs289645 chr10:37943642 T/C cg25427524 chr10:38739819 LOC399744 -0.69 -11.47 -0.53 7.69e-26 Extrinsic epigenetic age acceleration; CRC cis rs6495122 0.501 rs7167261 chr15:75343807 T/C cg09165964 chr15:75287851 SCAMP5 -0.51 -7.8 -0.39 8.34e-14 Caffeine consumption;Diastolic blood pressure;Coffee consumption; CRC cis rs796364 0.806 rs74266490 chr2:201005995 A/C cg25936922 chr2:200820526 C2orf60;C2orf47 -0.65 -6.15 -0.32 2.23e-9 Schizophrenia; CRC cis rs2692947 0.673 rs2229169 chr2:96780716 T/G cg23100626 chr2:96804247 ASTL -0.31 -8.57 -0.43 4.06e-16 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; CRC cis rs7954584 0.546 rs10840630 chr12:122352445 C/T cg21171335 chr12:122356390 WDR66 0.4 6.08 0.32 3.32e-9 Mean corpuscular volume; CRC cis rs8180040 0.966 rs17784882 chr3:47544003 C/A cg02527881 chr3:46936655 PTH1R 0.37 6.78 0.35 5.52e-11 Colorectal cancer; CRC cis rs6933660 0.760 rs1825368 chr6:151775259 C/A cg14262678 chr6:151773367 RMND1;C6orf211 0.55 9.08 0.45 1.03e-17 Menarche (age at onset); CRC cis rs7412746 0.611 rs111842513 chr1:150712926 G/A cg15448220 chr1:150897856 SETDB1 0.48 6.83 0.35 4.16e-11 Melanoma; CRC cis rs8058578 0.887 rs28421305 chr16:30838128 G/A cg02466173 chr16:30829666 NA -0.86 -13.99 -0.61 3.2e-35 Multiple myeloma; CRC cis rs5758511 0.680 rs739147 chr22:42671066 T/G cg00645731 chr22:42541494 CYP2D7P1 0.64 9.7 0.47 9.7e-20 Birth weight; CRC cis rs6700896 0.931 rs10789193 chr1:66129646 A/T cg04111102 chr1:66153794 NA 0.35 6.1 0.32 3.03e-9 C-reactive protein;Mean corpuscular volume;Mean corpuscular hemoglobin; CRC cis rs6598955 0.640 rs4233460 chr1:26633387 A/G cg04990556 chr1:26633338 UBXN11 -0.77 -12.79 -0.58 1.15e-30 Obesity-related traits; CRC cis rs2180341 0.924 rs9285459 chr6:127631113 T/C cg24812749 chr6:127587940 RNF146 0.95 13.71 0.6 3.81e-34 Breast cancer; CRC cis rs1448094 0.511 rs4469976 chr12:86146723 T/C cg18827107 chr12:86230957 RASSF9 0.39 5.96 0.31 6.52e-9 Major depressive disorder; CRC cis rs9467773 0.523 rs2498399 chr6:26706544 T/C cg09904177 chr6:26538194 HMGN4 0.6 8.55 0.43 4.86e-16 Intelligence (multi-trait analysis); CRC trans rs6819266 0.636 rs13148734 chr4:63330858 A/G cg25580254 chr12:8088937 SLC2A3 -0.39 -6.01 -0.31 5e-9 Age-related macular degeneration; CRC cis rs3026445 0.851 rs1502337 chr12:111062852 A/G cg12870014 chr12:110450643 ANKRD13A -0.42 -6.68 -0.35 1.03e-10 QT interval; CRC cis rs7904985 0.924 rs2217223 chr10:88111630 A/G cg07322936 chr10:88137208 NA 0.51 7.35 0.38 1.57e-12 Barrett's esophagus; CRC cis rs875971 0.651 rs2420596 chr7:65915983 T/C cg18252515 chr7:66147081 NA -0.4 -5.8 -0.3 1.57e-8 Aortic root size; CRC cis rs6502050 0.835 rs10163482 chr17:80110394 C/A cg09264619 chr17:80180166 NA -0.34 -5.81 -0.3 1.5e-8 Life satisfaction; CRC cis rs10504229 0.911 rs77203035 chr8:58175458 C/A cg02290350 chr8:58132656 NA -0.42 -5.96 -0.31 6.62e-9 Developmental language disorder (linguistic errors); CRC cis rs1799949 0.965 rs4793233 chr17:41435437 G/C cg25072359 chr17:41440525 NA 0.43 6.44 0.33 4.21e-10 Menopause (age at onset); CRC cis rs13256369 0.826 rs12678414 chr8:8586016 G/T cg00074818 chr8:8560427 CLDN23 0.31 5.68 0.3 2.94e-8 Obesity-related traits; CRC cis rs7071206 0.704 rs11002234 chr10:79434458 A/G cg07817648 chr10:79422355 NA -0.48 -6.42 -0.33 4.75e-10 Bone mineral density; CRC cis rs875971 0.545 rs7811204 chr7:65852200 G/A cg18876405 chr7:65276391 NA 0.47 6.41 0.33 5.04e-10 Aortic root size; CRC cis rs12142240 0.738 rs67545510 chr1:46806242 G/T cg14993813 chr1:46806288 NSUN4 -0.5 -6.37 -0.33 6.42e-10 Menopause (age at onset); CRC cis rs9733 0.596 rs11582840 chr1:150688487 A/G cg17724175 chr1:150552817 MCL1 0.57 9.12 0.45 7.76e-18 Tonsillectomy; CRC cis rs1552244 0.510 rs13075308 chr3:10034925 G/C cg13047869 chr3:10149882 C3orf24 0.51 6.97 0.36 1.74e-11 Alzheimer's disease; CRC cis rs7666738 0.791 rs10033211 chr4:98995624 T/A cg17366294 chr4:99064904 C4orf37 0.44 7.39 0.38 1.19e-12 Colonoscopy-negative controls vs population controls; CRC cis rs9287719 0.967 rs2024431 chr2:10731327 A/G cg00105475 chr2:10696890 NA 0.45 7.26 0.37 2.75e-12 Prostate cancer; CRC cis rs9894429 0.608 rs7406382 chr17:79597786 T/C cg13777783 chr17:79615861 NA -0.3 -5.7 -0.3 2.6e-8 Eye color traits; CRC cis rs881375 0.933 rs4837799 chr9:123668326 T/C cg00246817 chr9:123691163 NA -0.48 -6.12 -0.32 2.67e-9 Rheumatoid arthritis; CRC cis rs7917772 0.507 rs2778036 chr10:104485725 G/A cg04362960 chr10:104952993 NT5C2 -0.49 -6.09 -0.32 3.06e-9 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC cis rs10504229 0.683 rs34859456 chr8:58117722 A/C cg02290350 chr8:58132656 NA -0.58 -8.16 -0.41 7.29e-15 Developmental language disorder (linguistic errors); CRC cis rs13108904 0.967 rs62293658 chr4:1276416 T/C cg23123621 chr4:1343375 KIAA1530 -0.37 -7.01 -0.36 1.39e-11 Obesity-related traits; CRC cis rs4979906 1.000 rs11002248 chr10:79446961 A/G cg07817648 chr10:79422355 NA -0.43 -5.64 -0.3 3.57e-8 Mortality in heart failure; CRC cis rs1008375 1.000 rs7694020 chr4:17682597 C/T cg04450456 chr4:17643702 FAM184B 0.42 6.6 0.34 1.61e-10 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs929354 0.772 rs10229630 chr7:157004790 C/T cg17757837 chr7:157058334 UBE3C 0.74 12.6 0.57 5.8e-30 Body mass index; CRC cis rs3126085 0.935 rs3126056 chr1:152266503 G/A cg09127314 chr1:152161683 NA -0.45 -5.73 -0.3 2.33e-8 Atopic dermatitis; CRC cis rs514406 0.505 rs447581 chr1:53177098 T/C cg08859206 chr1:53392774 SCP2 -0.42 -6.6 -0.34 1.66e-10 Monocyte count; CRC cis rs9487051 0.768 rs9480910 chr6:109521707 T/C cg01475377 chr6:109611718 NA -0.33 -5.79 -0.3 1.62e-8 Reticulocyte fraction of red cells; CRC cis rs10946940 0.864 rs13201411 chr6:27498217 G/C cg21251018 chr6:28226885 NKAPL -0.42 -6.55 -0.34 2.28e-10 Systemic lupus erythematosus; CRC cis rs7940866 0.774 rs10466547 chr11:130823576 T/C cg12179176 chr11:130786555 SNX19 0.6 8.95 0.44 2.64e-17 Schizophrenia; CRC cis rs3785574 0.962 rs2584621 chr17:61912436 G/A cg22520471 chr17:61851767 DDX42;CCDC47 0.46 6.26 0.33 1.19e-9 Height; CRC cis rs629535 0.814 rs652483 chr8:70055083 G/A cg26132723 chr8:70041827 NA 0.35 5.71 0.3 2.59e-8 Dupuytren's disease; CRC cis rs11167764 0.945 rs891991 chr5:141484977 A/T cg23435118 chr5:141488016 NDFIP1 -0.47 -7.44 -0.38 8.88e-13 Crohn's disease; CRC trans rs6472235 0.778 rs58967538 chr8:66927783 G/C cg07884673 chr3:53033167 SFMBT1 -0.45 -6.03 -0.32 4.47e-9 Myopia (pathological);Plateletcrit; CRC cis rs7493 0.755 rs17883791 chr7:94999438 G/A cg20119798 chr7:94954144 PON1 -0.44 -5.61 -0.3 4.36e-8 Yu-Zhi constitution type in type 2 diabetes; CRC trans rs11088226 0.709 rs55860967 chr21:33880018 G/A cg09050820 chr6:167586206 TCP10L2 0.65 7.13 0.37 6.27e-12 Gastritis; CRC cis rs10416265 0.527 rs6510337 chr19:33545701 C/T cg17764715 chr19:33622953 WDR88 0.42 6.1 0.32 2.92e-9 Bone properties (heel); CRC cis rs2228479 0.702 rs62052710 chr16:89854893 C/T cg19635926 chr16:89946313 TCF25 0.63 5.61 0.3 4.35e-8 Skin colour saturation; CRC cis rs311392 0.902 rs413667 chr8:55091908 C/A cg20636351 chr8:55087400 NA -0.34 -6.07 -0.32 3.51e-9 Pelvic organ prolapse (moderate/severe); CRC trans rs2099149 0.748 rs354128 chr12:30505536 C/G cg21144006 chr12:74931510 LOC552889 0.5 6.39 0.33 5.6e-10 Cannabis use; CRC cis rs6540559 1.000 rs2235372 chr1:209960436 A/G cg23283495 chr1:209979779 IRF6 -0.46 -7.03 -0.36 1.22e-11 Cleft lip with or without cleft palate; CRC cis rs1401999 0.898 rs4148564 chr3:183725982 C/T cg20387954 chr3:183756860 HTR3D 0.46 7.95 0.4 3.09e-14 Anterior chamber depth; CRC cis rs9488822 0.636 rs12524932 chr6:116330266 G/A cg18764771 chr6:116381957 FRK 0.25 7.0 0.36 1.45e-11 Cholesterol, total;LDL cholesterol; CRC trans rs8002861 0.619 rs9562516 chr13:44431738 T/C cg17145862 chr1:211918768 LPGAT1 0.55 9.39 0.46 1.01e-18 Leprosy; CRC cis rs889312 0.500 rs865570 chr5:56161975 C/T cg03609598 chr5:56110824 MAP3K1 -0.42 -5.76 -0.3 1.95e-8 Breast cancer;Breast cancer (early onset); CRC cis rs7312933 0.558 rs4768399 chr12:42742696 G/A cg19980929 chr12:42632907 YAF2 -0.39 -5.91 -0.31 8.67e-9 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CRC cis rs12950390 0.893 rs4239165 chr17:45847272 A/T cg24803719 chr17:45855879 NA -0.3 -6.5 -0.34 3.04e-10 IgG glycosylation; CRC trans rs2727020 0.702 rs609054 chr11:49219725 C/G cg21153622 chr11:89784906 NA 0.43 6.9 0.36 2.64e-11 Coronary artery disease; CRC cis rs3749237 0.595 rs3870338 chr3:49557051 A/G cg07636037 chr3:49044803 WDR6 0.53 7.81 0.4 7.94e-14 Resting heart rate; CRC cis rs877282 0.853 rs7092805 chr10:756246 G/A cg17470449 chr10:769945 NA 0.62 8.1 0.41 1.08e-14 Uric acid levels; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg27449864 chr7:73133982 STX1A 0.39 6.14 0.32 2.38e-9 Intelligence (multi-trait analysis); CRC cis rs6952808 1.000 rs6954521 chr7:1886865 C/A cg00106254 chr7:1943704 MAD1L1 -0.44 -6.26 -0.33 1.22e-9 Bipolar disorder and schizophrenia; CRC cis rs6951245 0.872 rs74360401 chr7:1067403 G/A cg03188948 chr7:1209495 NA 0.63 6.52 0.34 2.64e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs780096 0.527 rs59644396 chr2:27646083 A/G cg17158414 chr2:27665306 KRTCAP3 -0.3 -6.55 -0.34 2.17e-10 Total body bone mineral density; CRC cis rs3862030 0.836 rs12771867 chr10:104246691 G/A cg11453585 chr10:104263688 ACTR1A;SUFU -0.79 -14.12 -0.61 1.05e-35 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for body mass index; CRC cis rs1018836 0.923 rs6998150 chr8:91645969 A/C cg16814680 chr8:91681699 NA -0.73 -11.4 -0.53 1.37e-25 Ejection fraction in Tripanosoma cruzi seropositivity; CRC trans rs9409565 0.516 rs114766729 chr9:97069901 C/T cg05679027 chr9:99775184 HIATL2 0.39 5.97 0.31 6.03e-9 Colorectal cancer (alcohol consumption interaction); CRC cis rs56775891 1.000 rs4799088 chr18:77573548 A/G cg24058013 chr18:77568902 NA -0.47 -7.89 -0.4 4.54e-14 Schizophrenia; CRC cis rs12681287 0.547 rs60982560 chr8:87515046 C/T cg27223183 chr8:87520930 FAM82B -0.53 -7.46 -0.38 7.85e-13 Caudate activity during reward; CRC trans rs66573146 0.656 rs111560662 chr4:6952766 C/T cg07817883 chr1:32538562 TMEM39B 1.25 12.24 0.56 1.25e-28 Granulocyte percentage of myeloid white cells; CRC cis rs929354 0.713 rs6946660 chr7:156948648 T/C cg16102536 chr7:156981717 UBE3C 0.4 6.69 0.35 9.57e-11 Body mass index; CRC cis rs8077889 1.000 rs2079005 chr17:41865627 T/G cg16892393 chr17:41919603 NA 0.56 7.83 0.4 6.58e-14 Triglycerides; CRC cis rs10256972 0.567 rs2960835 chr7:1202963 A/G cg16145915 chr7:1198662 ZFAND2A -0.5 -10.34 -0.5 6.9e-22 Longevity;Endometriosis; CRC cis rs910316 0.967 rs175432 chr14:75615246 C/G cg03030879 chr14:75389066 RPS6KL1 0.4 6.15 0.32 2.31e-9 Height; CRC cis rs12431939 0.779 rs2999381 chr14:51645368 T/C cg23942311 chr14:51606299 NA 0.49 6.81 0.35 4.68e-11 Cancer; CRC cis rs55788414 0.932 rs7185658 chr16:81189336 A/G cg06400318 chr16:81190750 PKD1L2 -0.62 -7.18 -0.37 4.55e-12 Left ventricular obstructive tract defect (maternal effect); CRC cis rs853679 0.517 rs3757187 chr6:28107654 T/C cg06470822 chr6:28175283 NA 1.0 13.33 0.59 1.06e-32 Depression; CRC cis rs11122272 0.525 rs2749713 chr1:231537921 T/C cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.59 -8.89 -0.44 4.24e-17 Hemoglobin concentration; CRC cis rs7385804 0.766 rs1734909 chr7:100309582 C/G cg16850897 chr7:100343110 ZAN 0.45 6.87 0.35 3.22e-11 Iron status biomarkers;Mean corpuscular hemoglobin;Hematocrit;Iron status biomarkers (transferrin saturation);Red blood cell count;Iron status biomarkers (iron levels);Mean corpuscular volume;Hematological parameters; CRC cis rs1552244 0.748 rs113890152 chr3:10085986 A/G cg02579736 chr3:10068473 FANCD2;CIDECP 1.06 13.98 0.61 3.57e-35 Alzheimer's disease; CRC cis rs7107174 1.000 rs2373009 chr11:77945815 T/A cg02023728 chr11:77925099 USP35 0.55 7.72 0.39 1.44e-13 Testicular germ cell tumor; CRC cis rs561341 0.941 rs17780086 chr17:30343282 G/A cg23018236 chr17:30244563 NA -0.68 -8.1 -0.41 1.12e-14 Hip circumference adjusted for BMI; CRC cis rs9486719 0.843 rs2205754 chr6:96843134 T/C cg06623918 chr6:96969491 KIAA0776 0.79 8.57 0.43 4.23e-16 Migraine;Coronary artery disease; CRC cis rs12143943 0.834 rs34812029 chr1:204546987 A/G cg17419461 chr1:204415978 PIK3C2B 0.42 6.47 0.34 3.5e-10 Cognitive performance; CRC cis rs2878628 0.596 rs57039206 chr3:52758570 T/A cg10802521 chr3:52805072 NEK4 -0.58 -9.14 -0.45 6.43e-18 Intelligence (multi-trait analysis); CRC cis rs72772090 0.539 rs11738115 chr5:96113072 A/T cg17330273 chr5:96107758 CAST;ERAP1 0.66 6.29 0.33 9.9e-10 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs6088590 1.000 rs28542147 chr20:33376323 G/A cg24642439 chr20:33292090 TP53INP2 0.6 10.56 0.5 1.26e-22 Coronary artery disease; CRC cis rs6952808 0.798 rs28970524 chr7:1927484 C/T cg22963979 chr7:1858916 MAD1L1 -0.51 -7.53 -0.38 4.99e-13 Bipolar disorder and schizophrenia; CRC trans rs9467711 0.606 rs68072215 chr6:26377927 T/C cg06606381 chr12:133084897 FBRSL1 -0.75 -6.01 -0.31 5.01e-9 Autism spectrum disorder or schizophrenia; CRC cis rs7274811 0.711 rs291698 chr20:31982250 A/T cg07470512 chr20:32255052 NECAB3;C20orf134 0.45 6.17 0.32 1.99e-9 Height; CRC cis rs35110281 0.805 rs2838317 chr21:44991791 A/C cg01579765 chr21:45077557 HSF2BP -0.37 -7.17 -0.37 5.07e-12 Mean corpuscular volume; CRC cis rs2635047 0.811 rs12962421 chr18:44787498 A/G cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.36 5.62 0.3 4.08e-8 Educational attainment; CRC cis rs4822044 0.680 rs8138780 chr22:42097462 A/T cg03806693 chr22:41940476 POLR3H 1.06 13.33 0.59 1.05e-32 Cannabis dependence symptom count; CRC cis rs10464366 0.544 rs4723824 chr7:39153698 T/C cg21665744 chr7:39171113 POU6F2 0.42 5.66 0.3 3.25e-8 IgG glycosylation; CRC cis rs561341 1.000 rs4795669 chr17:30244701 C/T cg00745463 chr17:30367425 LRRC37B -0.78 -8.66 -0.43 2.16e-16 Hip circumference adjusted for BMI; CRC cis rs10256972 0.621 rs2280725 chr7:1087426 G/T cg07308232 chr7:1071921 C7orf50 -0.48 -6.81 -0.35 4.77e-11 Longevity;Endometriosis; CRC cis rs910316 0.967 rs12890371 chr14:75593839 T/C cg11812906 chr14:75593930 NEK9 0.64 10.21 0.49 1.95e-21 Height; CRC cis rs8077889 0.956 rs4792910 chr17:41840229 T/C cg16892393 chr17:41919603 NA 0.5 6.99 0.36 1.5e-11 Triglycerides; CRC cis rs6662572 0.737 rs7555458 chr1:46554142 A/G cg08644498 chr1:46502608 NA 0.45 7.19 0.37 4.27e-12 Blood protein levels; CRC cis rs56235845 0.964 rs4075958 chr5:176784512 A/G cg17509989 chr5:176798049 RGS14 -0.85 -13.39 -0.59 6.09e-33 Hemoglobin concentration;Hematocrit; CRC trans rs61931739 0.500 rs1843736 chr12:34012080 C/G cg26384229 chr12:38710491 ALG10B 0.54 6.9 0.36 2.76e-11 Morning vs. evening chronotype; CRC trans rs2228479 0.702 rs17233441 chr16:89817998 C/G cg21302420 chr1:112162376 RAP1A 0.72 6.01 0.31 5.05e-9 Skin colour saturation; CRC cis rs9447004 0.584 rs7747167 chr6:74430673 T/G cg03006477 chr6:74432658 CD109 0.36 6.41 0.33 5.01e-10 Blood protein levels;Calcium levels; CRC cis rs9814567 0.964 rs9833753 chr3:134213665 A/G cg06541857 chr3:134203789 ANAPC13;CEP63 -0.41 -6.22 -0.32 1.48e-9 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs75920871 0.660 rs4938330 chr11:116928514 C/G cg20608306 chr11:116969690 SIK3 -0.32 -5.92 -0.31 8.16e-9 Subjective well-being; CRC cis rs6089584 0.888 rs6061966 chr20:60607936 C/G cg06108461 chr20:60628389 TAF4 -0.92 -15.74 -0.66 5.48e-42 Body mass index; CRC cis rs79349575 0.783 rs56046215 chr17:47008757 A/T cg22482690 chr17:47019901 SNF8 0.48 8.08 0.41 1.28e-14 Type 2 diabetes; CRC cis rs7666738 0.830 rs35685312 chr4:98858521 G/A cg17366294 chr4:99064904 C4orf37 0.41 6.67 0.35 1.08e-10 Colonoscopy-negative controls vs population controls; CRC cis rs6545883 0.929 rs7561229 chr2:61737990 A/T cg15711740 chr2:61764176 XPO1 -0.52 -7.17 -0.37 4.83e-12 Tuberculosis; CRC cis rs13096357 0.520 rs17080319 chr3:48732480 T/C cg00383909 chr3:49044727 WDR6 0.74 7.74 0.39 1.27e-13 Cognitive ability (multi-trait analysis); CRC cis rs2298450 0.550 rs36037816 chr21:37656115 C/T cg02919814 chr21:37666008 DOPEY2 -0.44 -6.43 -0.33 4.4e-10 Schizophrenia; CRC cis rs7932354 0.528 rs6485739 chr11:47145072 G/A cg03339077 chr11:47165057 C11orf49 0.5 7.3 0.37 2.22e-12 Bone mineral density (hip);Bone mineral density; CRC cis rs28386778 0.897 rs1062790 chr17:61896455 A/G cg11494091 chr17:61959527 GH2 0.6 10.1 0.49 4.51e-21 Prudent dietary pattern; CRC cis rs9733 0.519 rs11204717 chr1:150709129 T/A cg15448220 chr1:150897856 SETDB1 0.48 6.83 0.35 4.16e-11 Tonsillectomy; CRC cis rs1862618 0.853 rs832584 chr5:56179212 A/G cg12311346 chr5:56204834 C5orf35 0.71 9.68 0.47 1.15e-19 Initial pursuit acceleration; CRC trans rs916888 0.773 rs199445 chr17:44817408 C/T cg07870213 chr5:140052090 DND1 0.99 11.34 0.53 2.17e-25 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs13108904 0.934 rs13125842 chr4:1280947 G/A cg21620606 chr4:1342894 KIAA1530 0.36 5.91 0.31 8.33e-9 Obesity-related traits; CRC cis rs3741151 0.773 rs73542952 chr11:73108556 A/G cg17517138 chr11:73019481 ARHGEF17 0.97 7.95 0.4 2.97e-14 GIP levels in response to oral glucose tolerance test (120 minutes); CRC cis rs9368481 0.646 rs75843621 chr6:26967881 G/A cg18867708 chr6:26865862 GUSBL1 -0.41 -5.72 -0.3 2.34e-8 Autism spectrum disorder or schizophrenia; CRC cis rs4908768 0.539 rs922366 chr1:8653733 C/A cg20416874 chr1:8611966 RERE -0.42 -5.95 -0.31 6.76e-9 Neuroticism (multi-trait analysis);Subjective well-being (multi-trait analysis); CRC cis rs728616 0.571 rs113030473 chr10:81649031 G/T cg05935833 chr10:81318306 SFTPA2 -0.72 -7.59 -0.39 3.41e-13 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs13191362 0.810 rs13200053 chr6:163011443 G/A cg21926612 chr6:163149169 PACRG;PARK2 0.78 10.8 0.51 1.77e-23 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs2415984 0.622 rs10131871 chr14:46931700 A/G cg14871534 chr14:47121158 RPL10L 0.43 6.14 0.32 2.38e-9 Number of children ever born; CRC trans rs116095464 0.558 rs13354585 chr5:242263 G/C cg00938859 chr5:1591904 SDHAP3 0.73 7.77 0.39 9.95e-14 Breast cancer; CRC cis rs2153535 0.580 rs1360054 chr6:8520377 C/A cg07606381 chr6:8435919 SLC35B3 0.64 10.48 0.5 2.35e-22 Motion sickness; CRC cis rs2072510 0.593 rs2540497 chr12:96404275 A/T cg15438951 chr12:96389694 HAL -0.46 -5.65 -0.3 3.53e-8 Metabolite levels (small molecules and protein measures); CRC cis rs2625529 0.652 rs9302260 chr15:72174611 T/C cg16672083 chr15:72433130 SENP8 0.46 7.2 0.37 4.04e-12 Red blood cell count; CRC trans rs1814175 0.645 rs7952104 chr11:49964180 C/T cg15704280 chr7:45808275 SEPT13 -0.94 -16.56 -0.67 3.26e-45 Height; CRC cis rs8180040 0.966 rs11707895 chr3:47574937 G/A cg10298567 chr3:47292165 KIF9 0.36 5.63 0.3 3.9e-8 Colorectal cancer; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg12568633 chr10:73533407 CDH23;C10orf54 0.39 6.48 0.34 3.36e-10 Liver disease severity in Alagille syndrome; CRC cis rs2463822 0.748 rs2513038 chr11:62081329 A/C cg06239285 chr11:62104954 ASRGL1 0.93 10.63 0.51 6.74e-23 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs1799949 0.929 rs799906 chr17:41278116 T/C cg05368731 chr17:41323189 NBR1 0.63 9.57 0.47 2.74e-19 Menopause (age at onset); CRC cis rs6495122 0.501 rs12101482 chr15:75344784 A/T cg17294928 chr15:75287854 SCAMP5 -0.44 -6.49 -0.34 3.11e-10 Caffeine consumption;Diastolic blood pressure;Coffee consumption; CRC cis rs7546094 1.000 rs7544663 chr1:113089006 A/G cg22162597 chr1:113214053 CAPZA1 -0.44 -6.18 -0.32 1.94e-9 Platelet distribution width; CRC cis rs11203032 0.831 rs11203014 chr10:90940333 C/G cg16672925 chr10:90967113 CH25H 0.45 5.66 0.3 3.24e-8 Heart failure; CRC cis rs3008870 1.000 rs2985821 chr1:67403787 G/A cg08660285 chr1:67390436 MIER1;WDR78 1.02 15.1 0.64 1.64e-39 Lymphocyte percentage of white cells; CRC cis rs13082711 0.522 rs569960 chr3:27329540 C/T cg02860705 chr3:27208620 NA 0.45 6.8 0.35 5.05e-11 Systolic blood pressure;Diastolic blood pressure;Blood pressure; CRC cis rs3736594 0.643 rs2384655 chr2:27952235 A/T cg27432699 chr2:27873401 GPN1 -0.62 -8.8 -0.44 8.04e-17 Fasting blood glucose;Fasting blood glucose (BMI interaction); CRC cis rs7705042 0.828 rs6580224 chr5:141489306 A/G cg08523384 chr5:141488047 NDFIP1 -0.33 -5.86 -0.31 1.14e-8 Asthma; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg05842370 chr22:41682224 RANGAP1 0.42 6.72 0.35 8.11e-11 Liver disease severity in Alagille syndrome; CRC cis rs6912958 0.781 rs6454631 chr6:88225863 G/A cg08069147 chr6:88032118 GJB7;C6orf162 -0.53 -7.81 -0.4 7.74e-14 Monocyte percentage of white cells; CRC cis rs2231884 0.697 rs11227332 chr11:65623739 A/G cg04055107 chr11:65626734 MUS81;CFL1 0.65 6.76 0.35 6.42e-11 Inflammatory bowel disease; CRC cis rs7172677 0.501 rs56266638 chr15:75393205 T/A cg14664628 chr15:75095509 CSK 0.44 6.19 0.32 1.83e-9 Systemic lupus erythematosus and Systemic sclerosis; CRC cis rs8180040 0.577 rs12493425 chr3:47176946 T/G cg02527881 chr3:46936655 PTH1R -0.34 -6.05 -0.32 3.85e-9 Colorectal cancer; CRC cis rs9325144 0.600 rs10880934 chr12:38730455 C/T cg13010199 chr12:38710504 ALG10B -0.43 -6.09 -0.32 3.23e-9 Morning vs. evening chronotype; CRC cis rs10504229 0.906 rs56138544 chr8:58184558 A/C cg05313129 chr8:58192883 C8orf71 -0.47 -6.99 -0.36 1.49e-11 Developmental language disorder (linguistic errors); CRC cis rs7408868 0.908 rs1044006 chr19:15285052 T/C cg14696996 chr19:15285081 NOTCH3 0.96 8.96 0.44 2.53e-17 Pulse pressure; CRC cis rs9916302 0.851 rs11868029 chr17:37650304 A/G cg00129232 chr17:37814104 STARD3 -0.55 -8.05 -0.41 1.55e-14 Glomerular filtration rate (creatinine); CRC cis rs7843479 0.965 rs733544 chr8:21835628 A/G cg17168535 chr8:21777572 XPO7 0.56 9.25 0.45 2.96e-18 Mean corpuscular volume; CRC trans rs12310956 0.532 rs6488186 chr12:33974122 G/A cg26384229 chr12:38710491 ALG10B 0.48 6.42 0.33 4.73e-10 Morning vs. evening chronotype; CRC cis rs425277 1.000 rs262667 chr1:2082722 T/C cg24578937 chr1:2090814 PRKCZ 0.66 11.72 0.54 9.36e-27 Height; CRC cis rs9611565 0.659 rs12484694 chr22:41919330 A/G cg06481639 chr22:41940642 POLR3H -0.51 -5.91 -0.31 8.45e-9 Vitiligo; CRC cis rs7618915 0.501 rs62253740 chr3:52684128 A/T cg18099408 chr3:52552593 STAB1 -0.46 -7.87 -0.4 5.05e-14 Bipolar disorder; CRC cis rs763014 0.932 rs2269560 chr16:682442 A/C cg07343612 chr16:622815 PIGQ -0.78 -12.83 -0.58 7.99e-31 Height; CRC trans rs7647973 0.588 rs9883000 chr3:49667691 A/G cg21665057 chr3:196295764 WDR53;FBXO45 -0.62 -6.77 -0.35 5.95e-11 Menarche (age at onset); CRC cis rs2032447 0.772 rs199754 chr6:25992309 A/G cg04800585 chr6:26043546 HIST1H2BB 0.6 8.81 0.44 7.37e-17 Intelligence (multi-trait analysis); CRC cis rs477692 0.517 rs871026 chr10:131293145 A/G cg05714579 chr10:131428358 MGMT -0.56 -8.21 -0.41 5.07e-15 Response to temozolomide; CRC cis rs9910055 0.639 rs7217858 chr17:42254527 T/G cg16434002 chr17:42200994 HDAC5 -0.52 -7.53 -0.38 4.88e-13 Total body bone mineral density; CRC cis rs10504229 0.683 rs55868006 chr8:58135703 C/T cg21724239 chr8:58056113 NA 0.49 6.81 0.35 4.75e-11 Developmental language disorder (linguistic errors); CRC cis rs3733585 0.753 rs12500805 chr4:10017979 C/T cg00071950 chr4:10020882 SLC2A9 0.66 12.02 0.55 7.64e-28 Cleft plate (environmental tobacco smoke interaction); CRC cis rs9914544 0.628 rs4924924 chr17:18677774 C/G cg26306683 chr17:18585705 ZNF286B 0.39 5.73 0.3 2.3e-8 Educational attainment (years of education); CRC cis rs2274273 0.624 rs11848575 chr14:55755788 A/G cg10130446 chr14:55658398 DLGAP5 -0.41 -5.73 -0.3 2.24e-8 Protein biomarker; CRC cis rs6662572 0.737 rs4423055 chr1:46259980 T/C cg03123370 chr1:45965343 CCDC163P;MMACHC -0.48 -6.22 -0.32 1.52e-9 Blood protein levels; CRC cis rs7493 1.000 rs3779492 chr7:95044183 C/T cg04155289 chr7:94953770 PON1 -0.59 -7.48 -0.38 6.83e-13 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs6089584 0.854 rs2380146 chr20:60632233 C/T cg06108461 chr20:60628389 TAF4 -0.9 -15.63 -0.65 1.37e-41 Body mass index; CRC cis rs3126085 0.735 rs4845744 chr1:152185095 T/A cg09127314 chr1:152161683 NA 0.51 6.52 0.34 2.66e-10 Atopic dermatitis; CRC cis rs9393777 0.513 rs9379895 chr6:26592707 A/G cg12292205 chr6:26970375 C6orf41 -0.61 -6.9 -0.36 2.75e-11 Intelligence (multi-trait analysis); CRC cis rs9818758 0.607 rs34566463 chr3:49245077 T/C cg07636037 chr3:49044803 WDR6 -0.66 -5.85 -0.31 1.18e-8 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; CRC cis rs2075371 0.830 rs12669960 chr7:133931782 A/G cg20476274 chr7:133979776 SLC35B4 0.69 11.19 0.52 7.68e-25 Mean platelet volume; CRC cis rs992157 0.835 rs12987180 chr2:219144089 G/A cg13835894 chr2:219148914 PNKD;TMBIM1 -0.35 -6.76 -0.35 6.22e-11 Colorectal cancer; CRC cis rs28386778 0.863 rs9207 chr17:61823899 C/T cg11494091 chr17:61959527 GH2 0.6 10.29 0.49 1.01e-21 Prudent dietary pattern; CRC cis rs798554 0.591 rs757791 chr7:2867296 A/G cg04166393 chr7:2884313 GNA12 0.39 6.01 0.31 4.94e-9 Height; CRC cis rs2195987 0.874 rs4932934 chr19:24107333 T/A cg00460763 chr19:23944615 RPSAP58 0.54 5.8 0.3 1.55e-8 Testicular germ cell tumor; CRC cis rs3809566 0.526 rs35829897 chr15:63334688 G/C cg05507819 chr15:63340323 TPM1 -0.69 -9.35 -0.46 1.39e-18 Platelet count; CRC cis rs3736594 1.000 rs13013484 chr2:27988821 G/A cg27432699 chr2:27873401 GPN1 -0.6 -8.36 -0.42 1.74e-15 Fasting blood glucose;Fasting blood glucose (BMI interaction); CRC cis rs425277 0.606 rs262663 chr1:2084598 T/C cg12639453 chr1:2035780 PRKCZ 0.31 5.88 0.31 1.01e-8 Height; CRC cis rs5750830 0.649 rs5750814 chr22:39797987 T/C cg05872129 chr22:39784769 NA -0.63 -12.59 -0.57 6.21e-30 Intelligence (multi-trait analysis); CRC cis rs61160187 0.582 rs62372103 chr5:60145448 A/G cg16298547 chr5:60138761 ELOVL7 -0.28 -6.0 -0.31 5.11e-9 Educational attainment (years of education);Educational attainment (college completion); CRC cis rs4713118 0.662 rs9357060 chr6:28024486 C/G cg03623178 chr6:28175578 NA 0.92 13.05 0.58 1.2e-31 Parkinson's disease; CRC cis rs250677 0.652 rs168751 chr5:148438264 C/T cg18129178 chr5:148520854 ABLIM3 -0.39 -5.8 -0.3 1.58e-8 Breast cancer; CRC cis rs17376456 0.825 rs10072232 chr5:93398890 G/A cg09848695 chr5:92956644 FAM172A;MIR2277 0.61 5.68 0.3 2.95e-8 Diabetic retinopathy; CRC cis rs11229555 0.609 rs12270515 chr11:58217945 G/A cg15696309 chr11:58395628 NA -0.82 -10.57 -0.5 1.14e-22 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; CRC cis rs924607 1.000 rs924607 chr5:610093 C/T cg04221910 chr5:616842 CEP72 -0.41 -6.87 -0.35 3.22e-11 Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia; CRC cis rs2637266 0.558 rs1907331 chr10:78244948 T/C cg18941641 chr10:78392320 NA -0.34 -5.61 -0.3 4.32e-8 Pulmonary function; CRC cis rs12410462 0.681 rs76705164 chr1:227615570 G/A cg23173402 chr1:227635558 NA 0.75 8.2 0.41 5.54e-15 Major depressive disorder; CRC cis rs9894429 0.646 rs7210026 chr17:79612382 T/C cg09655341 chr17:79618100 PDE6G -0.35 -6.07 -0.32 3.5e-9 Eye color traits; CRC cis rs6502050 0.634 rs11077973 chr17:80095191 C/T cg11859384 chr17:80120422 CCDC57 -0.37 -5.85 -0.31 1.16e-8 Life satisfaction; CRC cis rs8180040 1.000 rs11130127 chr3:47398793 C/G cg02527881 chr3:46936655 PTH1R 0.39 7.1 0.36 7.7e-12 Colorectal cancer; CRC cis rs7772486 0.719 rs4391282 chr6:146276780 A/T cg23711669 chr6:146136114 FBXO30 -0.66 -11.15 -0.52 1.08e-24 Lobe attachment (rater-scored or self-reported); CRC cis rs1552244 0.882 rs13084194 chr3:10031492 T/A cg13047869 chr3:10149882 C3orf24 0.51 6.45 0.34 3.96e-10 Alzheimer's disease; CRC cis rs4713118 0.616 rs9348789 chr6:28025486 C/T cg18032046 chr6:28092343 ZSCAN16 -0.51 -6.46 -0.34 3.86e-10 Parkinson's disease; CRC cis rs9457247 0.565 rs2239824 chr6:167511799 T/A cg07741184 chr6:167504864 NA 0.48 7.99 0.4 2.25e-14 Crohn's disease; CRC cis rs9916302 0.706 rs4287601 chr17:37513852 T/C cg07936489 chr17:37558343 FBXL20 0.91 11.42 0.53 1.15e-25 Glomerular filtration rate (creatinine); CRC cis rs9443645 0.901 rs4415132 chr6:79554107 T/C cg11833968 chr6:79620685 NA -0.36 -6.36 -0.33 6.62e-10 Intelligence (multi-trait analysis); CRC cis rs2249296 0.586 rs4656108 chr1:86925400 A/G cg17424433 chr1:86913263 CLCA2 -0.42 -5.94 -0.31 7.13e-9 Crohn's disease-related phenotypes; CRC cis rs2836950 0.805 rs2836961 chr21:40627020 A/C cg17971929 chr21:40555470 PSMG1 -0.47 -6.16 -0.32 2.12e-9 Menarche (age at onset); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg22190833 chr7:150929518 CHPF2 0.33 6.58 0.34 1.83e-10 Liver disease severity in Alagille syndrome; CRC cis rs6500602 0.702 rs4786493 chr16:4500122 C/T cg14951292 chr16:4525986 HMOX2;NMRAL1 0.49 7.57 0.39 3.69e-13 Schizophrenia; CRC cis rs28386778 0.897 rs2028567 chr17:61915326 G/A cg22520471 chr17:61851767 DDX42;CCDC47 0.75 11.67 0.54 1.44e-26 Prudent dietary pattern; CRC trans rs7011507 1.000 rs76272647 chr8:49194001 G/A cg04544946 chr8:978226 NA 0.48 6.76 0.35 6.43e-11 Inflammatory bowel disease;Ulcerative colitis; CRC cis rs8180040 0.800 rs11921117 chr3:47294000 T/C cg10298567 chr3:47292165 KIF9 0.42 6.56 0.34 2.07e-10 Colorectal cancer; CRC cis rs1707322 1.000 rs785506 chr1:46540652 C/T cg03146154 chr1:46216737 IPP -0.51 -6.93 -0.36 2.27e-11 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs9858542 0.953 rs11711485 chr3:49491983 G/T cg03060546 chr3:49711283 APEH -0.46 -6.37 -0.33 6.29e-10 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs2976388 0.556 rs4736300 chr8:143829269 C/T cg04969067 chr8:143858791 LYNX1 -0.4 -6.12 -0.32 2.61e-9 Urinary tract infection frequency; CRC cis rs1005277 0.579 rs2983343 chr10:38383332 A/G cg17219203 chr10:38645113 HSD17B7P2 -0.41 -5.76 -0.3 1.89e-8 Extrinsic epigenetic age acceleration; CRC cis rs1552244 1.000 rs3826 chr3:10141065 T/G cg13047869 chr3:10149882 C3orf24 0.51 7.34 0.37 1.72e-12 Alzheimer's disease; CRC cis rs2124969 0.527 rs72982044 chr2:161049395 G/A cg03641300 chr2:160917029 PLA2R1 -0.63 -8.06 -0.41 1.47e-14 Waist circumference adjusted for body mass index; CRC cis rs644799 0.525 rs3016206 chr11:95536724 T/C cg25478527 chr11:95522999 CEP57;FAM76B 0.48 7.51 0.38 5.58e-13 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs8180040 1.000 rs1638676 chr3:47327651 A/G cg27129171 chr3:47204927 SETD2 0.57 8.88 0.44 4.4e-17 Colorectal cancer; CRC cis rs7786808 0.707 rs62479983 chr7:158227613 G/A cg17401720 chr7:158221031 PTPRN2 0.48 7.83 0.4 6.86e-14 Obesity-related traits; CRC cis rs11958404 0.932 rs72818108 chr5:157437883 A/T cg05962755 chr5:157440814 NA 1.01 12.88 0.58 5.12e-31 IgG glycosylation; CRC cis rs4713118 0.869 rs9468214 chr6:27713299 G/C cg21251018 chr6:28226885 NKAPL 0.38 5.64 0.3 3.58e-8 Parkinson's disease; CRC trans rs6550704 0.687 rs9865314 chr3:22634337 A/G cg05108160 chr13:110790284 NA -0.42 -6.27 -0.33 1.14e-9 Daytime sleep phenotypes; CRC cis rs8180040 0.729 rs11720439 chr3:47347003 T/G cg10298567 chr3:47292165 KIF9 0.39 6.03 0.32 4.51e-9 Colorectal cancer; CRC cis rs863345 0.604 rs11264985 chr1:158465166 C/T cg12129480 chr1:158549410 OR10X1 -0.3 -6.35 -0.33 7.19e-10 Pneumococcal bacteremia; CRC cis rs7258465 1.000 rs7252707 chr19:18612257 G/A cg06462663 chr19:18546047 ISYNA1 0.47 7.04 0.36 1.15e-11 Breast cancer; CRC cis rs6964587 0.967 rs7788092 chr7:91646198 C/T cg17063962 chr7:91808500 NA 0.83 14.98 0.64 4.88e-39 Breast cancer; CRC cis rs6728642 0.708 rs56807297 chr2:97861340 A/C cg26665480 chr2:98280029 ACTR1B -0.53 -5.63 -0.3 3.89e-8 Bipolar disorder lithium response (continuous) or schizophrenia; CRC cis rs10504229 0.569 rs75466737 chr8:58055034 A/G cg02290350 chr8:58132656 NA -0.62 -7.02 -0.36 1.27e-11 Developmental language disorder (linguistic errors); CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg00676969 chr14:74485475 ENTPD5;C14orf45 -0.42 -6.32 -0.33 8.28e-10 Myopia (pathological); CRC cis rs4718428 1.000 rs12534637 chr7:66327654 G/C cg00343986 chr7:65444356 GUSB 0.43 5.81 0.3 1.48e-8 Corneal structure; CRC cis rs8060686 0.841 rs73594554 chr16:67920049 G/A cg26727032 chr16:67993705 SLC12A4 -0.59 -7.17 -0.37 4.92e-12 HDL cholesterol;Metabolic syndrome; CRC cis rs11098499 0.954 rs9685777 chr4:120365965 C/A cg24375607 chr4:120327624 NA 0.51 7.98 0.4 2.49e-14 Corneal astigmatism; CRC cis rs992157 0.798 rs7587220 chr2:219160864 C/A cg04880052 chr2:219191631 PNKD -0.44 -6.93 -0.36 2.24e-11 Colorectal cancer; CRC cis rs10504229 0.683 rs11781690 chr8:58132931 C/G cg22535103 chr8:58192502 C8orf71 -0.7 -9.34 -0.46 1.47e-18 Developmental language disorder (linguistic errors); CRC cis rs17270561 0.609 rs4145216 chr6:25743559 G/A cg16482183 chr6:26056742 HIST1H1C 0.83 10.69 0.51 4.46e-23 Iron status biomarkers; CRC cis rs17666538 0.535 rs1669658 chr8:607380 A/G cg10396713 chr8:602097 NA 0.56 5.66 0.3 3.35e-8 IgG glycosylation; CRC cis rs10876993 0.928 rs813854 chr12:58071347 A/G cg15848620 chr12:58087721 OS9 -0.6 -8.33 -0.42 2.17e-15 Celiac disease or Rheumatoid arthritis; CRC cis rs7666738 0.830 rs7684646 chr4:99071062 C/T cg17366294 chr4:99064904 C4orf37 0.44 7.37 0.38 1.37e-12 Colonoscopy-negative controls vs population controls; CRC cis rs7584330 0.704 rs11884395 chr2:238359366 C/T cg11271282 chr2:238384023 NA 0.46 5.81 0.3 1.5e-8 Prostate cancer; CRC cis rs2811415 0.597 rs9869012 chr3:127728663 C/T cg13719885 chr3:127795394 NA -0.39 -5.9 -0.31 8.84e-9 Lung function (FEV1/FVC); CRC cis rs875971 0.862 rs1643375 chr7:65872677 T/C cg00343986 chr7:65444356 GUSB 0.41 5.87 0.31 1.09e-8 Aortic root size; CRC cis rs67478160 0.619 rs11160759 chr14:104231542 C/T cg08213375 chr14:104286397 PPP1R13B 0.65 13.66 0.6 6.03e-34 Schizophrenia; CRC cis rs1448094 0.512 rs7133591 chr12:86239752 G/C cg00310523 chr12:86230176 RASSF9 0.34 5.79 0.3 1.67e-8 Major depressive disorder; CRC cis rs13191362 0.872 rs13206549 chr6:162978032 T/G cg23758597 chr6:163146217 PARK2 -0.56 -5.74 -0.3 2.2e-8 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs7945718 0.805 rs11022510 chr11:12833262 G/A cg25843174 chr11:12811716 TEAD1 0.46 8.55 0.43 4.58e-16 Educational attainment (years of education); CRC cis rs2019137 0.560 rs4849179 chr2:113985170 C/T cg19083407 chr2:113993142 PAX8;LOC440839;LOC654433 0.58 8.67 0.43 2.07e-16 Lymphocyte counts; CRC trans rs916888 0.610 rs199529 chr17:44837217 A/C cg07870213 chr5:140052090 DND1 0.9 10.29 0.49 1e-21 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs12451471 0.559 rs1042396 chr17:78084769 G/A cg20811857 chr17:78079795 GAA -0.46 -6.69 -0.35 9.75e-11 Plateletcrit;Mean corpuscular hemoglobin concentration; CRC cis rs9549367 0.737 rs71446680 chr13:113894846 C/T cg00898013 chr13:113819073 PROZ -0.45 -6.45 -0.33 4.11e-10 Platelet distribution width; CRC cis rs8180040 0.654 rs6766230 chr3:47196209 C/A cg27129171 chr3:47204927 SETD2 0.72 11.38 0.53 1.64e-25 Colorectal cancer; CRC cis rs250677 0.687 rs1422581 chr5:148437386 C/T cg23229984 chr5:148520753 ABLIM3 -0.47 -6.31 -0.33 8.8e-10 Breast cancer; CRC cis rs8078723 1.000 rs4795415 chr17:38157995 C/T cg17467752 chr17:38218738 THRA 0.73 11.82 0.55 4.15e-27 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); CRC cis rs56235845 0.694 rs11749830 chr5:176766547 G/A cg17261708 chr5:176794207 RGS14 0.48 7.82 0.4 7.35e-14 Hemoglobin concentration;Hematocrit; CRC cis rs6952808 0.929 rs4721217 chr7:1973579 C/T cg04267008 chr7:1944627 MAD1L1 -0.78 -10.95 -0.52 5.3e-24 Bipolar disorder and schizophrenia; CRC cis rs9595066 1.000 rs4942282 chr13:44708416 G/A cg04068111 chr13:44716778 NA -0.51 -6.46 -0.34 3.86e-10 Schizophrenia; CRC cis rs6545883 0.929 rs1186711 chr2:61688505 T/C cg15711740 chr2:61764176 XPO1 -0.46 -6.01 -0.31 4.85e-9 Tuberculosis; CRC cis rs9322193 0.923 rs2880436 chr6:150180259 T/C cg05861140 chr6:150128134 PCMT1 -0.43 -6.67 -0.35 1.08e-10 Lung cancer; CRC cis rs12701220 0.894 rs13224488 chr7:1052353 C/A cg00990874 chr7:1149470 C7orf50 -0.59 -6.88 -0.35 2.99e-11 Bronchopulmonary dysplasia; CRC cis rs2153535 0.580 rs2327056 chr6:8443305 C/T cg07606381 chr6:8435919 SLC35B3 0.68 10.86 0.51 1.08e-23 Motion sickness; CRC cis rs1670533 1.000 rs6821725 chr4:1060360 C/G cg27284194 chr4:1044797 NA 0.5 6.22 0.32 1.51e-9 Recombination rate (females); CRC cis rs524281 0.692 rs2302884 chr11:65824084 C/T cg14036092 chr11:66035641 RAB1B -0.44 -5.79 -0.3 1.67e-8 Electroencephalogram traits; CRC cis rs17376456 0.825 rs17372649 chr5:93126096 C/G cg25358565 chr5:93447407 FAM172A 1.0 9.41 0.46 9.08e-19 Diabetic retinopathy; CRC cis rs28386778 0.863 rs58269663 chr17:61843130 G/A cg25654072 chr17:61904446 PSMC5;FTSJ3 0.73 11.3 0.53 2.96e-25 Prudent dietary pattern; CRC cis rs7666738 0.830 rs10005120 chr4:99038200 A/G cg17366294 chr4:99064904 C4orf37 0.44 7.43 0.38 9.65e-13 Colonoscopy-negative controls vs population controls; CRC cis rs7849270 1.000 rs10819464 chr9:131876277 G/A cg13538475 chr9:131942899 NA -0.3 -6.15 -0.32 2.22e-9 Blood metabolite ratios; CRC cis rs561341 0.882 rs72825748 chr17:30367396 G/A cg12193833 chr17:30244370 NA -0.74 -8.62 -0.43 2.87e-16 Hip circumference adjusted for BMI; CRC cis rs3767633 0.925 rs4233380 chr1:161892483 A/C cg09175582 chr1:161736000 ATF6 0.69 6.27 0.33 1.14e-9 IgG glycosylation; CRC cis rs7772486 0.727 rs4896843 chr6:146063451 T/C cg23711669 chr6:146136114 FBXO30 -0.75 -12.66 -0.57 3.36e-30 Lobe attachment (rater-scored or self-reported); CRC cis rs2625529 0.591 rs7172158 chr15:72405313 T/C cg16672083 chr15:72433130 SENP8 0.47 6.82 0.35 4.37e-11 Red blood cell count; CRC trans rs11712655 1.000 rs9860731 chr3:135225679 G/T cg14625040 chr2:6214447 NA -0.44 -6.2 -0.32 1.7e-9 Visceral adipose tissue/subcutaneous adipose tissue ratio; CRC cis rs6540556 0.723 rs12116437 chr1:209897027 G/A cg05527609 chr1:210001259 C1orf107 -0.62 -6.72 -0.35 8.2e-11 Red blood cell count; CRC cis rs2836974 0.604 rs2854727 chr21:40713787 A/G cg17971929 chr21:40555470 PSMG1 0.51 7.25 0.37 2.92e-12 Cognitive function; CRC cis rs6500602 0.727 rs11644481 chr16:4581002 T/G cg08645402 chr16:4508243 NA 0.63 10.91 0.52 7.39e-24 Schizophrenia; CRC trans rs7027930 0.524 rs7029777 chr9:612433 A/G cg27061366 chr19:13044373 FARSA 0.47 6.0 0.31 5.3e-9 Pulmonary function decline; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg09192942 chr16:75682004 KARS;TERF2IP 0.43 6.79 0.35 5.17e-11 Liver disease severity in Alagille syndrome; CRC cis rs6502050 0.835 rs9891962 chr17:80153594 T/C cg13198984 chr17:80129470 CCDC57 0.45 7.96 0.4 2.75e-14 Life satisfaction; CRC cis rs2657888 0.628 rs2638335 chr12:56880672 C/T cg23002907 chr12:56915593 RBMS2 -0.4 -6.28 -0.33 1.08e-9 Adiponectin levels; CRC cis rs1577917 0.917 rs35283633 chr6:86690787 C/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.53 -6.64 -0.34 1.32e-10 Response to antipsychotic treatment; CRC cis rs4819052 0.851 rs7276591 chr21:46680156 C/T cg11663144 chr21:46675770 NA -0.85 -14.73 -0.63 4.41e-38 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs7487075 0.893 rs4768116 chr12:46733030 G/T cg22049899 chr12:47219821 SLC38A4 0.35 6.82 0.35 4.45e-11 Itch intensity from mosquito bite; CRC cis rs3823572 0.564 rs10272509 chr7:133636302 A/G cg03336402 chr7:133662267 EXOC4 0.67 10.32 0.49 8.37e-22 Intelligence (multi-trait analysis); CRC cis rs2153535 0.580 rs9505455 chr6:8478622 A/G cg07606381 chr6:8435919 SLC35B3 0.68 10.89 0.51 8.84e-24 Motion sickness; CRC cis rs1218582 0.688 rs2135219 chr1:154857217 G/A cg09359103 chr1:154839909 KCNN3 -0.75 -11.82 -0.55 4.23e-27 Prostate cancer; CRC cis rs597539 0.616 rs513476 chr11:68698996 C/T cg21963583 chr11:68658836 MRPL21 0.59 10.51 0.5 1.75e-22 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs7487075 0.859 rs7961994 chr12:46755112 A/T cg22049899 chr12:47219821 SLC38A4 0.32 5.89 0.31 9.34e-9 Itch intensity from mosquito bite; CRC cis rs4665809 0.590 rs13016300 chr2:26468365 G/C cg26119090 chr2:26468346 HADHA;HADHB 1.06 15.5 0.65 4.69e-41 Gut microbiome composition (summer); CRC cis rs4731207 0.967 rs2267708 chr7:124392512 C/T cg23710748 chr7:124431027 NA 0.4 6.49 0.34 3.2e-10 Cutaneous malignant melanoma; CRC cis rs6748734 1.000 rs3936203 chr2:241834654 C/T cg04034577 chr2:241836375 C2orf54 0.41 8.67 0.43 2e-16 Urinary metabolites; CRC cis rs9916302 0.706 rs4488484 chr17:37717377 A/T cg00129232 chr17:37814104 STARD3 0.55 6.96 0.36 1.83e-11 Glomerular filtration rate (creatinine); CRC cis rs2075371 0.829 rs35897155 chr7:134002711 G/A cg20476274 chr7:133979776 SLC35B4 0.67 10.66 0.51 5.3e-23 Mean platelet volume; CRC trans rs7165102 1.000 rs6494521 chr15:65739928 A/T cg22383888 chr3:27764816 EOMES -0.28 -5.99 -0.31 5.61e-9 Mean corpuscular hemoglobin; CRC cis rs9549328 0.614 rs34306822 chr13:113616499 G/A cg24588162 chr13:113633484 MCF2L 0.36 6.43 0.33 4.47e-10 Systolic blood pressure; CRC trans rs1814175 0.817 rs4881645 chr11:49791168 G/A cg03929089 chr4:120376271 NA -0.97 -18.93 -0.72 1.36e-54 Height; CRC cis rs898097 0.691 rs7222773 chr17:80907283 A/G cg10494973 chr17:80897199 TBCD -0.36 -5.63 -0.3 3.9e-8 Breast cancer; CRC cis rs13064411 0.591 rs7628945 chr3:113201754 A/T cg18753928 chr3:113234510 CCDC52 -0.53 -8.2 -0.41 5.32e-15 Response to simvastatin treatment (PCSK9 protein level change); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg05358749 chr7:23145602 KLHL7 0.47 7.18 0.37 4.82e-12 Intelligence (multi-trait analysis); CRC cis rs7904368 0.754 rs12253908 chr10:16853358 T/C cg23933602 chr10:16859644 RSU1 0.54 5.96 0.31 6.36e-9 Ratio of the peak velocity of the mitral E-Wave divided by the peak velocity of the mitral A-wave.; CRC cis rs6502050 0.835 rs34673303 chr17:80085144 G/C cg02741985 chr17:80059408 CCDC57 -0.44 -7.15 -0.37 5.61e-12 Life satisfaction; CRC cis rs9487051 0.844 rs9386792 chr6:109609975 G/A cg21918786 chr6:109611834 NA -0.45 -8.19 -0.41 5.98e-15 Reticulocyte fraction of red cells; CRC cis rs7739232 0.920 rs17216194 chr6:53528467 C/T cg15658676 chr6:53530538 KLHL31 -0.76 -5.9 -0.31 8.9e-9 Hip circumference adjusted for BMI; CRC trans rs916888 0.773 rs199533 chr17:44828931 G/A cg22968622 chr17:43663579 NA 1.46 18.42 0.71 1.48e-52 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs1124376 0.832 rs6793985 chr3:20136485 T/C cg05072819 chr3:20081367 KAT2B 0.46 5.78 0.3 1.7e-8 Bipolar disorder and schizophrenia; CRC cis rs10256972 0.521 rs871019 chr7:1105230 A/G cg03923535 chr7:1197113 ZFAND2A 0.51 7.61 0.39 2.89e-13 Longevity;Endometriosis; CRC cis rs728616 0.681 rs17100316 chr10:81913337 A/G cg11900509 chr10:81946545 ANXA11 -0.72 -8.54 -0.43 4.91e-16 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs2404602 0.669 rs12916324 chr15:77179603 G/A cg23625390 chr15:77176239 SCAPER 0.46 6.53 0.34 2.56e-10 Blood metabolite levels; CRC cis rs8180040 0.764 rs12629262 chr3:47196580 C/T cg02527881 chr3:46936655 PTH1R -0.4 -7.44 -0.38 8.8e-13 Colorectal cancer; CRC cis rs6495122 0.699 rs34862454 chr15:75101530 C/T cg14664628 chr15:75095509 CSK -0.72 -11.89 -0.55 2.29e-27 Caffeine consumption;Diastolic blood pressure;Coffee consumption; CRC cis rs891088 0.695 rs35296670 chr19:7198004 G/A cg00428638 chr19:7224713 INSR -0.62 -7.6 -0.39 3.04e-13 Hip circumference adjusted for BMI;Height; CRC trans rs10982213 0.830 rs2274163 chr9:117188714 C/T cg10800280 chr6:36646508 CDKN1A 0.38 5.96 0.31 6.55e-9 Interleukin-6 levels; CRC cis rs2976388 0.578 rs3736010 chr8:143817503 T/C cg05569086 chr8:143859399 LYNX1 -0.4 -6.12 -0.32 2.59e-9 Urinary tract infection frequency; CRC trans rs2303319 0.504 rs62187612 chr2:162432494 A/G cg18122310 chr12:50236657 BCDIN3D -0.75 -6.2 -0.32 1.68e-9 Cognitive function; CRC cis rs12681287 0.547 rs9942823 chr8:87509177 A/G cg27223183 chr8:87520930 FAM82B -0.52 -7.37 -0.38 1.38e-12 Caudate activity during reward; CRC cis rs929596 0.728 rs6744284 chr2:234625297 C/T cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.62 -9.78 -0.47 5.52e-20 Total bilirubin levels in HIV-1 infection; CRC cis rs28386778 0.897 rs968719 chr17:61908271 C/T cg22520471 chr17:61851767 DDX42;CCDC47 0.78 11.58 0.54 3.08e-26 Prudent dietary pattern; CRC cis rs1799949 0.965 rs799916 chr17:41243190 G/T cg05368731 chr17:41323189 NBR1 -0.64 -9.74 -0.47 7.51e-20 Menopause (age at onset); CRC cis rs7465272 0.530 rs10103161 chr8:143738571 A/G cg24634471 chr8:143751801 JRK 0.52 7.2 0.37 4.23e-12 Bipolar disorder and schizophrenia; CRC trans rs1005277 0.579 rs9299760 chr10:38377920 C/T cg17830980 chr10:43048298 ZNF37B -0.58 -9.69 -0.47 1.08e-19 Extrinsic epigenetic age acceleration; CRC cis rs910187 0.624 rs6063077 chr20:45787261 C/T cg27589058 chr20:45804311 EYA2 -0.34 -6.15 -0.32 2.24e-9 Migraine; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg17156767 chr19:30364462 NA 0.41 6.55 0.34 2.27e-10 Liver disease severity in Alagille syndrome; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg04433306 chr7:129592730 UBE2H 0.42 6.29 0.33 9.88e-10 Liver disease severity in Alagille syndrome; CRC cis rs13108904 0.539 rs13145722 chr4:1338422 T/A cg21620606 chr4:1342894 KIAA1530 0.51 8.19 0.41 5.9e-15 Obesity-related traits; CRC trans rs6819266 0.636 rs13148734 chr4:63330858 A/G cg20340149 chr2:122407145 CLASP1 0.38 5.99 0.31 5.6e-9 Age-related macular degeneration; CRC cis rs477692 0.699 rs471390 chr10:131382825 A/G cg05714579 chr10:131428358 MGMT -0.45 -6.41 -0.33 5.1e-10 Response to temozolomide; CRC cis rs7677751 0.806 rs4864863 chr4:55100831 A/G cg13615338 chr4:55094005 PDGFRA 0.4 5.62 0.3 3.97e-8 Corneal astigmatism; CRC cis rs1185460 0.967 rs4545564 chr11:118937518 T/C cg23280166 chr11:118938394 VPS11 0.44 6.71 0.35 8.71e-11 Coronary artery disease; CRC cis rs853679 0.607 rs34950484 chr6:28278688 G/A cg26958806 chr6:27640298 NA 0.93 6.56 0.34 2.11e-10 Depression; CRC cis rs847649 0.692 rs10279449 chr7:102462636 T/C cg18108683 chr7:102477205 FBXL13 -0.67 -11.27 -0.53 3.85e-25 Morning vs. evening chronotype; CRC cis rs559928 0.606 rs17773078 chr11:63906224 G/A cg19465662 chr11:63993652 NUDT22;TRPT1 0.7 6.72 0.35 7.98e-11 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; CRC cis rs1580019 0.562 rs4720064 chr7:32559638 G/A cg14728415 chr7:32535168 LSM5;AVL9 0.44 6.28 0.33 1.07e-9 Cognitive ability; CRC cis rs875971 1.000 rs1144895 chr7:65541307 C/G cg18876405 chr7:65276391 NA -0.52 -8.8 -0.44 7.65e-17 Aortic root size; CRC cis rs2836974 0.899 rs34978594 chr21:40580003 C/T cg11644478 chr21:40555479 PSMG1 0.81 12.33 0.56 5.44e-29 Cognitive function; CRC trans rs2303319 0.504 rs1023835 chr2:162593973 A/G cg04551154 chr10:95462393 C10orf4 -0.75 -6.37 -0.33 6.43e-10 Cognitive function; CRC cis rs950169 0.922 rs4842940 chr15:84831225 C/T cg11189052 chr15:85197271 WDR73 -0.63 -8.95 -0.44 2.65e-17 Schizophrenia; CRC cis rs7208859 0.673 rs999797 chr17:29159329 G/A cg14008862 chr17:28927542 LRRC37B2 0.55 5.74 0.3 2.11e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs10883723 0.810 rs7094751 chr10:104274818 G/A cg22532475 chr10:104410764 TRIM8 -0.36 -6.79 -0.35 5.39e-11 Allergic disease (asthma, hay fever or eczema); CRC cis rs8099014 0.770 rs1135519 chr18:56117145 C/T cg12907477 chr18:56117327 MIR122 0.47 5.97 0.31 6.1e-9 Platelet count; CRC cis rs13191362 0.573 rs9365499 chr6:163271833 C/T cg21926612 chr6:163149169 PACRG;PARK2 0.55 7.71 0.39 1.5e-13 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs9649213 0.574 rs34717219 chr7:97962271 A/C cg24562669 chr7:97807699 LMTK2 0.43 7.06 0.36 9.7e-12 Prostate cancer (SNP x SNP interaction); CRC cis rs11792861 0.781 rs28361152 chr9:111727529 T/C cg05043794 chr9:111880884 C9orf5 -0.33 -5.88 -0.31 1.01e-8 Menarche (age at onset); CRC cis rs780096 0.526 rs7602534 chr2:27592423 C/T cg17158414 chr2:27665306 KRTCAP3 -0.27 -5.62 -0.3 3.99e-8 Total body bone mineral density; CRC cis rs832540 0.966 rs252923 chr5:56205662 T/G cg24531977 chr5:56204891 C5orf35 -0.48 -7.56 -0.38 4.02e-13 Coronary artery disease; CRC cis rs6088580 0.634 rs4911151 chr20:32932273 T/C cg08999081 chr20:33150536 PIGU -0.64 -11.93 -0.55 1.69e-27 Glomerular filtration rate (creatinine); CRC cis rs12928939 0.517 rs12149307 chr16:71968091 A/C cg03805757 chr16:71968109 PKD1L3 -0.6 -7.92 -0.4 3.75e-14 Post bronchodilator FEV1; CRC cis rs853679 0.517 rs9393890 chr6:28063855 C/T cg23161317 chr6:28129485 ZNF389 0.52 6.38 0.33 6.1e-10 Depression; CRC cis rs9811920 0.569 rs793445 chr3:99576644 T/A cg07805332 chr3:99536008 MIR548G;C3orf26 0.52 7.75 0.39 1.17e-13 Axial length; CRC cis rs4713118 0.868 rs760587 chr6:27740300 C/A cg06470822 chr6:28175283 NA 0.85 9.7 0.47 1.01e-19 Parkinson's disease; CRC cis rs4819052 0.851 rs2877020 chr21:46658742 C/T cg11663144 chr21:46675770 NA -0.83 -14.12 -0.61 9.88e-36 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs45509595 0.659 rs390764 chr6:27782535 C/T cg19041857 chr6:27730383 NA -0.72 -6.75 -0.35 6.7e-11 Breast cancer; CRC cis rs35110281 0.782 rs9981790 chr21:45045052 G/C cg01579765 chr21:45077557 HSF2BP -0.36 -6.9 -0.36 2.65e-11 Mean corpuscular volume; CRC cis rs727505 1.000 rs56321835 chr7:124529622 T/C cg23710748 chr7:124431027 NA -0.85 -15.05 -0.64 2.7e-39 Lewy body disease; CRC cis rs9486715 0.867 rs9386500 chr6:96889845 A/C cg06623918 chr6:96969491 KIAA0776 1.01 20.26 0.75 7.99e-60 Headache; CRC cis rs4727027 0.870 rs62507512 chr7:148799338 C/T cg12479418 chr7:148823350 ZNF425;ZNF398 0.47 6.3 0.33 9.5e-10 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC trans rs1814175 0.647 rs10769646 chr11:49992204 C/A cg11707556 chr5:10655725 ANKRD33B -0.52 -10.05 -0.48 6.61e-21 Height; CRC cis rs2153535 0.580 rs9328483 chr6:8521295 A/G cg07606381 chr6:8435919 SLC35B3 0.64 10.48 0.5 2.35e-22 Motion sickness; CRC cis rs17641971 0.619 rs7013425 chr8:49953085 G/A cg00325661 chr8:49890786 NA 0.36 6.27 0.33 1.11e-9 Blood metabolite levels; CRC cis rs1448094 0.511 rs56291271 chr12:86162287 G/A cg25456477 chr12:86230367 RASSF9 0.38 6.43 0.33 4.41e-10 Major depressive disorder; CRC cis rs597539 0.652 rs673821 chr11:68678718 G/T cg04772025 chr11:68637568 NA 0.51 7.95 0.4 3.04e-14 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs6701037 0.566 rs1883102 chr1:175136793 T/A cg14847009 chr1:175162515 KIAA0040 0.29 6.55 0.34 2.26e-10 Alcohol dependence; CRC cis rs6691722 0.503 rs1142057 chr1:24706292 C/T cg02336364 chr1:24764700 NIPAL3 -0.38 -6.64 -0.34 1.3e-10 Response to interferon beta in multiple sclerosis; CRC cis rs8010715 0.848 rs927494 chr14:24600390 A/T cg23112188 chr14:24563095 PCK2 -0.39 -7.57 -0.39 3.74e-13 IgG glycosylation; CRC cis rs6951245 1.000 rs77346188 chr7:1114023 C/A cg24642844 chr7:1081250 C7orf50 -0.77 -9.14 -0.45 6.6e-18 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs1129187 0.791 rs1129186 chr6:42932202 C/T cg10862848 chr6:42927986 GNMT -0.39 -9.33 -0.46 1.6e-18 Alzheimer's disease in APOE e4+ carriers; CRC cis rs6502050 0.835 rs7219180 chr17:80079968 C/G cg22110888 chr17:80059540 CCDC57 -0.41 -6.38 -0.33 6.13e-10 Life satisfaction; CRC cis rs2239547 0.522 rs9831409 chr3:52985711 A/T cg15147215 chr3:52552868 STAB1 0.38 5.86 0.31 1.11e-8 Schizophrenia; CRC cis rs2153535 0.563 rs1796687 chr6:8536118 C/G cg21535247 chr6:8435926 SLC35B3 0.5 7.58 0.39 3.46e-13 Motion sickness; CRC cis rs1401999 1.000 rs2176824 chr3:183654029 C/G cg20387954 chr3:183756860 HTR3D 0.46 7.81 0.4 7.86e-14 Anterior chamber depth; CRC cis rs270601 0.633 rs733300 chr5:131572243 A/G cg12564285 chr5:131593104 PDLIM4 0.56 10.07 0.49 5.93e-21 Acylcarnitine levels; CRC cis rs7945705 0.747 rs1123936 chr11:9003306 A/G cg21881798 chr11:8931708 C11orf17;ST5 -0.65 -10.93 -0.52 6.27e-24 Hemoglobin concentration; CRC cis rs950169 0.922 rs8037078 chr15:84818871 A/G cg17507749 chr15:85114479 UBE2QP1 -0.73 -10.64 -0.51 6.46e-23 Schizophrenia; CRC cis rs909674 0.524 rs5750821 chr22:39825492 A/T cg24399712 chr22:39784796 NA -0.51 -10.67 -0.51 4.98e-23 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; CRC cis rs55702914 0.628 rs55813500 chr2:198389172 G/A cg10820045 chr2:198174542 NA 0.33 5.88 0.31 1.02e-8 Major depression and alcohol dependence; CRC cis rs1847505 0.559 rs1475496 chr13:61566031 G/C cg14094164 chr13:61491000 NA 0.33 6.22 0.32 1.47e-9 Polychlorinated biphenyl levels; CRC cis rs1552244 1.000 rs67006488 chr3:10152993 T/C cg16606324 chr3:10149918 C3orf24 0.72 9.56 0.47 2.94e-19 Alzheimer's disease; CRC trans rs875971 0.545 rs1638735 chr7:66095738 C/T cg02869306 chr7:64672164 INTS4L1 -0.45 -6.45 -0.34 3.89e-10 Aortic root size; CRC cis rs2404602 0.735 rs4886493 chr15:76679026 A/G cg03037974 chr15:76606532 NA -0.51 -7.61 -0.39 2.83e-13 Blood metabolite levels; CRC cis rs35762459 1 rs35762459 chr11:8844653 T/TA cg14711859 chr11:8959438 ASCL3 0.44 7.4 0.38 1.13e-12 Immature fraction of reticulocytes; CRC cis rs9921222 0.632 rs11649268 chr16:398643 A/C cg12437481 chr16:420112 MRPL28 -0.75 -12.38 -0.56 3.83e-29 Bone mineral density (spine);Bone mineral density; CRC trans rs58106596 0.800 rs67402940 chr2:232566499 T/C cg01370599 chr3:116745421 NA 0.52 7.1 0.36 7.73e-12 White blood cell count;Lymphocyte counts; CRC cis rs9329289 0.610 rs10903783 chr10:2540623 C/T cg15501526 chr10:2543763 NA 0.54 10.43 0.5 3.5e-22 Age-related hearing impairment; CRC trans rs8002861 0.727 rs9525850 chr13:44402100 C/T cg12856521 chr11:46389249 DGKZ -0.48 -7.92 -0.4 3.77e-14 Leprosy; CRC cis rs13191362 1.000 rs34192365 chr6:163012382 T/G cg21926612 chr6:163149169 PACRG;PARK2 0.79 10.93 0.52 6.15e-24 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs10504229 0.728 rs72650867 chr8:58154912 C/T cg22535103 chr8:58192502 C8orf71 -0.68 -8.37 -0.42 1.72e-15 Developmental language disorder (linguistic errors); CRC trans rs116095464 0.558 rs1971229 chr5:268187 A/G cg00938859 chr5:1591904 SDHAP3 0.73 7.85 0.4 5.98e-14 Breast cancer; CRC trans rs459571 0.959 rs410876 chr9:136893867 C/A cg15028160 chr19:49622717 PPFIA3;C19orf73 -0.57 -7.15 -0.37 5.64e-12 Platelet distribution width; CRC trans rs7267979 0.966 rs6083818 chr20:25346082 G/A cg17903999 chr18:56338584 MALT1 0.42 7.01 0.36 1.37e-11 Liver enzyme levels (alkaline phosphatase); CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg06938063 chr1:207925405 CD46 0.51 6.7 0.35 9.02e-11 Thyroid stimulating hormone; CRC cis rs2404602 0.669 rs17367297 chr15:77158026 A/C cg03037974 chr15:76606532 NA 0.69 11.63 0.54 2.04e-26 Blood metabolite levels; CRC cis rs317689 0.718 rs315130 chr12:69761444 T/C cg14784868 chr12:69753453 YEATS4 0.58 7.11 0.36 7.3e-12 Response to diuretic therapy; CRC cis rs9311474 0.508 rs7652191 chr3:52610415 T/C cg08222913 chr3:52553049 STAB1 -0.34 -6.39 -0.33 5.78e-10 Electroencephalogram traits; CRC cis rs709400 0.663 rs3783402 chr14:103967929 C/G cg12935359 chr14:103987150 CKB -0.53 -8.49 -0.42 7.03e-16 Body mass index; CRC cis rs1448094 0.533 rs7955135 chr12:86146350 G/A cg06740227 chr12:86229804 RASSF9 -0.37 -5.64 -0.3 3.71e-8 Major depressive disorder; CRC cis rs13064411 0.660 rs1872747 chr3:113175785 T/A cg18753928 chr3:113234510 CCDC52 -0.64 -8.49 -0.42 7.39e-16 Response to simvastatin treatment (PCSK9 protein level change); CRC cis rs7727544 0.716 rs10058655 chr5:131570896 A/T cg14196790 chr5:131705035 SLC22A5 0.36 6.34 0.33 7.57e-10 Blood metabolite levels; CRC cis rs3736485 0.844 rs62014659 chr15:51818591 G/C cg08986416 chr15:51914746 DMXL2 -0.46 -6.73 -0.35 7.7e-11 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs9486719 0.895 rs12195315 chr6:96905711 T/G cg06623918 chr6:96969491 KIAA0776 -0.81 -9.31 -0.46 1.82e-18 Migraine;Coronary artery disease; CRC trans rs951252 0.504 rs11734405 chr4:146081096 C/T cg22696252 chr3:97540975 NA 0.44 5.97 0.31 6.18e-9 Hip circumference; CRC cis rs17092148 0.887 rs6058077 chr20:33140999 G/A cg08999081 chr20:33150536 PIGU 0.5 6.34 0.33 7.36e-10 Neuroticism; CRC cis rs561341 0.769 rs559228 chr17:30294527 T/C cg23018236 chr17:30244563 NA -0.65 -7.78 -0.39 9.41e-14 Hip circumference adjusted for BMI; CRC cis rs7072216 0.881 rs2147896 chr10:100148176 A/G cg26618903 chr10:100175079 PYROXD2 -0.39 -6.63 -0.34 1.41e-10 Metabolite levels; CRC cis rs4555082 0.874 rs2816625 chr14:105734565 G/A cg18132624 chr14:105716052 BTBD6;BRF1 -0.47 -7.51 -0.38 5.64e-13 Mean platelet volume;Platelet distribution width; CRC cis rs6860806 0.507 rs272883 chr5:131668698 A/G cg24060327 chr5:131705240 SLC22A5 -0.51 -7.62 -0.39 2.67e-13 Breast cancer; CRC cis rs4713118 0.869 rs9366700 chr6:27696951 C/T cg20933634 chr6:27740509 NA 0.58 8.5 0.42 6.74e-16 Parkinson's disease; CRC cis rs11098499 0.697 rs35280960 chr4:120257059 G/A cg24375607 chr4:120327624 NA 0.45 6.88 0.35 3.06e-11 Corneal astigmatism; CRC cis rs7647973 0.593 rs7652179 chr3:49808618 T/A cg13072238 chr3:49761600 GMPPB 0.52 5.68 0.3 2.91e-8 Menarche (age at onset); CRC cis rs10782582 0.593 rs114421765 chr1:76141802 C/T cg03433033 chr1:76189801 ACADM -0.43 -6.17 -0.32 1.97e-9 Daytime sleep phenotypes; CRC cis rs2832191 0.755 rs2832192 chr21:30491173 G/T cg08807101 chr21:30365312 RNF160 -0.61 -9.43 -0.46 7.53e-19 Dental caries; CRC cis rs9902453 0.765 rs2169810 chr17:28167941 A/G cg26525008 chr17:28256777 EFCAB5;SSH2 0.7 11.75 0.54 7.16e-27 Coffee consumption (cups per day); CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg11276198 chr12:25404189 KRAS 0.44 6.2 0.32 1.72e-9 Anxiety disorder; CRC cis rs12497850 0.864 rs12493001 chr3:49181885 A/G cg07636037 chr3:49044803 WDR6 0.94 14.88 0.63 1.17e-38 Parkinson's disease; CRC cis rs832540 0.656 rs6893754 chr5:56100006 G/A cg03609598 chr5:56110824 MAP3K1 -0.43 -5.88 -0.31 1.01e-8 Coronary artery disease; CRC cis rs13256369 0.802 rs11249887 chr8:8562184 T/C cg18904891 chr8:8559673 CLDN23 0.53 7.13 0.37 6.34e-12 Obesity-related traits; CRC cis rs11971779 0.648 rs6967836 chr7:139079944 C/G cg23387468 chr7:139079360 LUC7L2 0.4 6.86 0.35 3.34e-11 Diisocyanate-induced asthma; CRC cis rs9583531 0.527 rs12875067 chr13:111365104 A/G cg24331049 chr13:111365604 ING1 0.57 7.93 0.4 3.54e-14 Coronary artery disease; CRC cis rs4073582 0.595 rs555360 chr11:65960061 T/C cg16950941 chr11:66035639 RAB1B -0.66 -11.26 -0.53 4.3e-25 Gout; CRC cis rs2908197 0.713 rs2961038 chr7:75952070 G/C cg10167463 chr7:75959203 YWHAG -0.38 -5.61 -0.3 4.35e-8 3-hydroxypropylmercapturic acid levels in smokers; CRC cis rs8072100 0.576 rs7216112 chr17:45406345 C/T cg08085267 chr17:45401833 C17orf57 0.65 10.39 0.5 4.63e-22 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg20386705 chr6:38607295 BTBD9 0.44 6.25 0.33 1.3e-9 Response to antipsychotic treatment; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg09380636 chr19:4791861 FEM1A 0.44 6.49 0.34 3.07e-10 Response to antipsychotic treatment; CRC cis rs1552244 0.832 rs73024591 chr3:10203194 A/T cg00166722 chr3:10149974 C3orf24 0.66 7.51 0.38 5.52e-13 Alzheimer's disease; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg03984733 chr9:116139085 HDHD3 0.43 5.96 0.31 6.39e-9 Response to antipsychotic treatment; CRC cis rs950776 0.684 rs692780 chr15:78876505 C/G cg06917634 chr15:78832804 PSMA4 -0.58 -8.56 -0.43 4.47e-16 Sudden cardiac arrest; CRC cis rs561341 0.941 rs72825736 chr17:30330286 G/A cg00745463 chr17:30367425 LRRC37B -0.88 -9.63 -0.47 1.7e-19 Hip circumference adjusted for BMI; CRC cis rs6690583 1.000 rs6690583 chr1:85466337 A/G cg11262906 chr1:85462892 MCOLN2 -0.52 -7.33 -0.37 1.82e-12 Serum sulfate level; CRC cis rs12134245 0.719 rs61798831 chr1:91996588 C/T cg25838465 chr1:92012736 NA -0.68 -12.57 -0.57 7.32e-30 Breast cancer; CRC cis rs4919694 1.000 rs12261040 chr10:104665397 T/C cg04362960 chr10:104952993 NT5C2 1.05 9.84 0.48 3.29e-20 Arsenic metabolism; CRC cis rs12760731 0.623 rs10798604 chr1:178254568 A/G cg00404053 chr1:178313656 RASAL2 -0.63 -7.97 -0.4 2.6e-14 Obesity-related traits; CRC cis rs11166927 0.901 rs7827091 chr8:140812044 G/C cg16909799 chr8:140841666 TRAPPC9 0.37 5.72 0.3 2.37e-8 Pediatric non-alcoholic fatty liver disease activity score; CRC cis rs950776 0.518 rs1504545 chr15:78818471 C/G cg06917634 chr15:78832804 PSMA4 -0.68 -11.14 -0.52 1.12e-24 Sudden cardiac arrest; CRC cis rs9916302 0.904 rs9904334 chr17:37468336 G/A cg00129232 chr17:37814104 STARD3 0.55 8.26 0.41 3.49e-15 Glomerular filtration rate (creatinine); CRC cis rs190945449 1 rs190945449 chr6:26828359 C/T cg16898833 chr6:26189333 HIST1H4D 0.85 6.36 0.33 6.65e-10 Urinary tract infection frequency; CRC cis rs514406 0.861 rs503015 chr1:53254456 T/C cg27535305 chr1:53392650 SCP2 0.39 6.97 0.36 1.72e-11 Monocyte count; CRC trans rs1814175 0.645 rs10839448 chr11:49938930 G/A cg15704280 chr7:45808275 SEPT13 -0.94 -16.66 -0.68 1.23e-45 Height; CRC cis rs12541635 0.966 rs11782609 chr8:106967919 G/A cg10147462 chr8:107024639 NA 0.43 6.9 0.36 2.7e-11 Age of smoking initiation; CRC cis rs1124376 0.882 rs6791385 chr3:20136439 A/C cg05072819 chr3:20081367 KAT2B 0.46 5.78 0.3 1.7e-8 Bipolar disorder and schizophrenia; CRC cis rs6570726 0.818 rs9399555 chr6:145877554 T/C cg05347473 chr6:146136440 FBXO30 0.37 5.73 0.3 2.3e-8 Lobe attachment (rater-scored or self-reported); CRC cis rs2952156 0.883 rs12150603 chr17:37834715 G/A cg11212589 chr17:38028394 ZPBP2 0.34 6.02 0.32 4.64e-9 Asthma; CRC cis rs6582630 0.539 rs8189604 chr12:38308546 G/T cg13010199 chr12:38710504 ALG10B -0.4 -5.75 -0.3 2.05e-8 Drug-induced liver injury (flucloxacillin); CRC cis rs17021463 0.902 rs2865352 chr4:95253263 A/G cg11021082 chr4:95130006 SMARCAD1 -0.51 -8.09 -0.41 1.13e-14 Testicular germ cell tumor; CRC trans rs1200821 0.641 rs11011162 chr10:37674483 G/C cg25427524 chr10:38739819 LOC399744 0.43 6.34 0.33 7.62e-10 Hemostatic factors and hematological phenotypes; CRC cis rs4363385 0.747 rs1577963 chr1:152961882 T/C cg25856811 chr1:152973957 SPRR3 -0.26 -7.27 -0.37 2.62e-12 Inflammatory skin disease; CRC cis rs25645 0.830 rs4072639 chr17:38189049 G/A cg17467752 chr17:38218738 THRA -0.54 -7.96 -0.4 2.76e-14 Myeloid white cell count; CRC cis rs6502050 0.835 rs62078304 chr17:80085224 G/A cg22110888 chr17:80059540 CCDC57 -0.41 -6.46 -0.34 3.81e-10 Life satisfaction; CRC cis rs10078 0.515 rs6872510 chr5:481610 T/C cg08916839 chr5:415575 AHRR 0.81 7.92 0.4 3.59e-14 Fat distribution (HIV); CRC cis rs875971 0.898 rs6977501 chr7:65693342 T/C cg18876405 chr7:65276391 NA -0.53 -9.01 -0.44 1.73e-17 Aortic root size; CRC cis rs4423214 1.000 rs12790558 chr11:71170905 T/C cg05163923 chr11:71159392 DHCR7 0.66 9.28 0.46 2.32e-18 Vitamin D levels; CRC cis rs11997175 0.583 rs7829680 chr8:33794207 C/T cg04338863 chr8:33670619 NA -0.4 -6.2 -0.32 1.67e-9 Body mass index; CRC cis rs7552404 0.696 rs67487205 chr1:76373756 T/C cg10523679 chr1:76189770 ACADM 0.74 8.89 0.44 4.18e-17 Blood metabolite levels;Acylcarnitine levels; CRC cis rs1218582 0.772 rs4845694 chr1:154911651 C/G cg09359103 chr1:154839909 KCNN3 -0.7 -12.3 -0.56 7.44e-29 Prostate cancer; CRC cis rs972578 1.000 rs11913527 chr22:43364634 G/C cg01576275 chr22:43409880 NA -0.45 -7.27 -0.37 2.62e-12 Mean platelet volume; CRC cis rs3768617 0.510 rs10797851 chr1:183098001 A/G ch.1.3577855R chr1:183094577 LAMC1 0.89 15.86 0.66 1.84e-42 Fuchs's corneal dystrophy; CRC cis rs7666738 0.830 rs17027090 chr4:98897923 G/T cg17366294 chr4:99064904 C4orf37 0.42 6.96 0.36 1.86e-11 Colonoscopy-negative controls vs population controls; CRC cis rs6580649 0.783 rs1635526 chr12:48396785 C/T cg05342945 chr12:48394962 COL2A1 -0.46 -6.37 -0.33 6.3e-10 Lung cancer; CRC cis rs782590 0.935 rs782606 chr2:55886602 T/C cg18811423 chr2:55921094 PNPT1 0.82 15.42 0.65 9.44e-41 Metabolic syndrome; CRC cis rs2072499 0.932 rs3001790 chr1:156165290 T/G cg06970220 chr1:156163860 SLC25A44 0.5 7.05 0.36 1.05e-11 Testicular germ cell tumor; CRC cis rs17152411 0.901 rs7098050 chr10:126657015 G/T cg07906193 chr10:126599966 NA 0.59 6.02 0.31 4.78e-9 Height; CRC cis rs58688157 0.883 rs7936397 chr11:577534 G/A cg01842473 chr11:617407 IRF7;MUPCDH -0.66 -8.85 -0.44 5.42e-17 Systemic lupus erythematosus; CRC cis rs2075371 0.933 rs1833474 chr7:133958240 A/G cg02659138 chr7:134003124 SLC35B4 0.36 6.24 0.33 1.33e-9 Mean platelet volume; CRC cis rs17270561 0.609 rs9379783 chr6:25725207 C/T cg17691542 chr6:26056736 HIST1H1C 0.63 8.12 0.41 9.35e-15 Iron status biomarkers; CRC cis rs2898681 0.561 rs58577680 chr4:53734294 C/T cg00338735 chr4:53728038 RASL11B 0.43 5.65 0.3 3.51e-8 Optic nerve measurement (cup area); CRC cis rs172166 0.694 rs203893 chr6:28062066 C/A cg21251018 chr6:28226885 NKAPL 0.47 7.22 0.37 3.59e-12 Cardiac Troponin-T levels; CRC cis rs868943 0.582 rs34224224 chr6:116464219 A/T cg15226275 chr6:116381976 FRK 0.26 6.08 0.32 3.31e-9 Total cholesterol levels; CRC cis rs5167 0.506 rs35193317 chr19:45470344 C/T cg13119609 chr19:45449297 APOC2 -0.36 -6.53 -0.34 2.45e-10 Blood protein levels; CRC trans rs1005277 0.522 rs7090858 chr10:38003670 A/C cg27523141 chr10:43048294 ZNF37B -0.44 -6.42 -0.33 4.79e-10 Extrinsic epigenetic age acceleration; CRC trans rs1728785 0.901 rs8050289 chr16:68566976 T/A cg04657470 chr2:198365150 HSPE1;HSPD1 0.57 6.73 0.35 7.6e-11 Ulcerative colitis; CRC cis rs7772486 0.738 rs9485039 chr6:146319387 C/T cg23711669 chr6:146136114 FBXO30 0.67 11.26 0.53 4.34e-25 Lobe attachment (rater-scored or self-reported); CRC cis rs1881797 0.872 rs2141544 chr1:247690800 A/G cg18198730 chr1:247681584 NA 0.59 10.56 0.5 1.19e-22 Acute lymphoblastic leukemia (childhood); CRC cis rs7523050 0.643 rs34114412 chr1:109402866 C/T cg08274380 chr1:109419600 GPSM2 0.85 6.65 0.34 1.24e-10 Fat distribution (HIV); CRC cis rs728616 0.867 rs17884637 chr10:81687922 G/C cg05935833 chr10:81318306 SFTPA2 -0.72 -8.19 -0.41 5.8e-15 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs763014 0.932 rs2384975 chr16:651115 G/T cg00908189 chr16:619842 PIGQ 0.68 11.58 0.54 3.17e-26 Height; CRC cis rs10883723 0.810 rs3781289 chr10:104244991 G/T cg11453585 chr10:104263688 ACTR1A;SUFU 0.92 16.99 0.68 6.29e-47 Allergic disease (asthma, hay fever or eczema); CRC cis rs875971 0.545 rs1796217 chr7:66085918 A/G cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.59 -7.43 -0.38 9.24e-13 Aortic root size; CRC cis rs10791323 0.569 rs10791335 chr11:133739571 A/T cg15485101 chr11:133734466 NA 0.42 7.9 0.4 4.19e-14 Childhood ear infection; CRC cis rs172166 0.769 rs149965 chr6:28018689 T/A cg03623178 chr6:28175578 NA 0.77 11.36 0.53 1.86e-25 Cardiac Troponin-T levels; CRC cis rs1577917 0.958 rs12215265 chr6:86443969 C/A cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.54 -7.34 -0.37 1.73e-12 Response to antipsychotic treatment; CRC cis rs881375 0.967 rs758959 chr9:123676699 C/T cg09586646 chr9:123605570 PSMD5;LOC253039 0.51 7.0 0.36 1.44e-11 Rheumatoid arthritis; CRC trans rs57221529 0.766 rs56216231 chr5:581193 G/A cg25482853 chr8:67687455 SGK3 1.25 15.0 0.64 4.06e-39 Lung disease severity in cystic fibrosis; CRC cis rs728616 0.867 rs55835350 chr10:81801728 A/T cg11900509 chr10:81946545 ANXA11 -0.57 -6.19 -0.32 1.77e-9 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs8072100 0.570 rs9905073 chr17:45468296 G/A cg25173405 chr17:45401733 C17orf57 -0.45 -6.8 -0.35 4.92e-11 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg19721215 chr19:13001564 GCDH 0.42 6.1 0.32 2.98e-9 Intelligence (multi-trait analysis); CRC cis rs116095464 0.558 rs56043030 chr5:220917 A/G cg22857025 chr5:266934 NA -1.23 -16.9 -0.68 1.4300000000000001e-46 Breast cancer; CRC cis rs7618501 0.633 rs4688758 chr3:50028385 G/A cg24308560 chr3:49941425 MST1R -0.51 -8.22 -0.41 4.87e-15 Intelligence (multi-trait analysis); CRC cis rs7618501 0.602 rs2240326 chr3:50128386 G/A cg24110177 chr3:50126178 RBM5 0.48 7.17 0.37 4.97e-12 Intelligence (multi-trait analysis); CRC cis rs11711311 1.000 rs4362695 chr3:113534856 A/G cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.51 -6.95 -0.36 1.92e-11 IgG glycosylation; CRC cis rs4819052 0.851 rs9977178 chr21:46664531 G/T cg02159808 chr21:46707872 POFUT2;LOC642852 0.48 6.32 0.33 8.27e-10 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs9479482 0.967 rs11752529 chr6:150347971 C/T cg25797454 chr6:150327115 RAET1K 0.38 6.47 0.34 3.51e-10 Alopecia areata; CRC cis rs2832191 0.791 rs2832179 chr21:30480366 C/T cg24692254 chr21:30365293 RNF160 -0.7 -12.39 -0.56 3.29e-29 Dental caries; CRC cis rs9341808 0.718 rs9352806 chr6:80980057 G/T cg08355045 chr6:80787529 NA 0.39 6.63 0.34 1.39e-10 Sitting height ratio; CRC cis rs629535 0.725 rs639127 chr8:70073251 A/G cg26132723 chr8:70041827 NA 0.35 5.71 0.3 2.51e-8 Dupuytren's disease; CRC cis rs11148252 0.766 rs74697307 chr13:52897573 C/T cg12458913 chr13:53173898 NA -0.53 -8.22 -0.41 4.8e-15 Lewy body disease; CRC trans rs2055729 0.710 rs112406488 chr8:9736362 T/C cg06636001 chr8:8085503 FLJ10661 0.57 6.94 0.36 2.03e-11 Multiple myeloma (hyperdiploidy); CRC cis rs6665290 0.594 rs17592479 chr1:227173892 T/A cg10327440 chr1:227177885 CDC42BPA -0.96 -19.7 -0.74 1.34e-57 Myeloid white cell count; CRC trans rs4650994 1.000 rs17276513 chr1:178520604 A/T cg05059571 chr16:84539110 KIAA1609 0.49 7.6 0.39 3.07e-13 HDL cholesterol levels;HDL cholesterol; CRC cis rs172166 0.515 rs2622320 chr6:28115336 T/A cg15845792 chr6:28175446 NA 0.64 9.61 0.47 1.97e-19 Cardiac Troponin-T levels; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg18387017 chr1:1167389 SDF4;B3GALT6 0.37 6.02 0.31 4.59e-9 Liver disease severity in Alagille syndrome; CRC trans rs4308415 0.726 rs1390069 chr4:67802098 G/T cg19648955 chr2:177134095 MTX2 -0.41 -5.99 -0.31 5.44e-9 Educational attainment (years of education); CRC cis rs77972916 0.517 rs17406126 chr2:43546632 A/T cg06169590 chr2:43455088 ZFP36L2;LOC100129726 -0.64 -5.85 -0.31 1.21e-8 Granulocyte percentage of myeloid white cells; CRC cis rs910316 1.000 rs9805979 chr14:75566209 G/A cg03030879 chr14:75389066 RPS6KL1 -0.46 -7.25 -0.37 2.99e-12 Height; CRC cis rs12477438 0.765 rs1054042 chr2:99614396 G/T cg14399236 chr2:99771627 LIPT1;TSGA10 -0.6 -8.29 -0.42 2.88e-15 Chronic sinus infection; CRC trans rs7299538 0.966 rs7963439 chr12:46084699 G/A cg20672981 chr7:27242161 NA -0.44 -6.07 -0.32 3.52e-9 Gut microbiome composition (winter); CRC cis rs9443645 0.838 rs9350800 chr6:79729489 A/C cg09184832 chr6:79620586 NA -0.51 -9.21 -0.45 4.07e-18 Intelligence (multi-trait analysis); CRC cis rs2456568 0.775 rs1607404 chr11:93660449 C/G cg26875233 chr11:93583750 C11orf90 -0.33 -6.36 -0.33 6.89e-10 Response to serotonin reuptake inhibitors in major depressive disorder; CRC cis rs941873 0.772 rs7086293 chr10:81103247 T/C cg09469691 chr10:81107165 PPIF 0.51 8.01 0.4 1.96e-14 Height; CRC cis rs17443541 0.507 rs10196380 chr2:200456655 G/C cg03741458 chr2:200468445 NA -0.36 -5.69 -0.3 2.77e-8 Intelligence (multi-trait analysis); CRC cis rs28386778 0.830 rs7209321 chr17:61855668 A/C cg06873352 chr17:61820015 STRADA 0.78 14.56 0.63 2.02e-37 Prudent dietary pattern; CRC cis rs977987 0.806 rs1895490 chr16:75392806 G/A cg03315344 chr16:75512273 CHST6 0.54 9.08 0.45 1.06e-17 Dupuytren's disease; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg15555727 chr8:144692268 PYCRL 0.43 6.37 0.33 6.23e-10 Intelligence (multi-trait analysis); CRC cis rs1153858 0.943 rs67045941 chr15:45677011 A/G cg10760299 chr15:45669010 GATM 0.5 7.82 0.4 7.18e-14 Homoarginine levels; CRC cis rs477895 0.713 rs3802933 chr11:63988102 C/T cg05016508 chr11:63871570 FLRT1;MACROD1 0.56 7.15 0.37 5.72e-12 Mean platelet volume; CRC cis rs947211 1.000 rs1775151 chr1:205745684 C/T cg24503407 chr1:205819492 PM20D1 0.46 6.23 0.32 1.46e-9 Parkinson's disease; CRC cis rs9858542 0.953 rs6446272 chr3:49463287 G/A cg07274523 chr3:49395745 GPX1 0.47 6.34 0.33 7.62e-10 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs1552244 1.000 rs6414438 chr3:10073824 G/C cg00166722 chr3:10149974 C3orf24 0.64 8.73 0.43 1.3e-16 Alzheimer's disease; CRC cis rs2749592 0.505 rs7915670 chr10:37870212 T/C cg25427524 chr10:38739819 LOC399744 0.67 11.1 0.52 1.53e-24 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs875971 0.545 rs6950988 chr7:65976415 C/T cg18876405 chr7:65276391 NA 0.44 6.15 0.32 2.3e-9 Aortic root size; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg23893906 chr12:6798535 ZNF384 -0.39 -5.97 -0.31 6e-9 Myopia (pathological); CRC cis rs6743376 0.556 rs957201 chr2:113821200 T/C cg24553058 chr2:113831203 IL1F10 0.43 7.15 0.37 5.56e-12 Inflammatory biomarkers; CRC cis rs172166 0.694 rs1770131 chr6:28086413 C/T cg25164649 chr6:28176230 NA 0.64 8.97 0.44 2.29e-17 Cardiac Troponin-T levels; CRC cis rs7044106 0.500 rs56725168 chr9:123492576 T/G cg09586646 chr9:123605570 PSMD5;LOC253039 0.74 11.2 0.53 7.07e-25 Hip circumference adjusted for BMI; CRC cis rs7412746 0.597 rs868751 chr1:150669414 T/G cg15448220 chr1:150897856 SETDB1 0.48 6.86 0.35 3.44e-11 Melanoma; CRC cis rs10791323 0.593 rs2282604 chr11:133714672 A/G cg03690763 chr11:133734501 NA -0.34 -5.72 -0.3 2.37e-8 Childhood ear infection; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg00515161 chr17:59940900 BRIP1 -0.48 -7.52 -0.38 5.21e-13 Liver disease severity in Alagille syndrome; CRC cis rs9733 0.596 rs56058687 chr1:150635066 C/T cg17724175 chr1:150552817 MCL1 0.58 9.4 0.46 9.25e-19 Tonsillectomy; CRC cis rs977987 0.806 rs12448947 chr16:75462954 G/A cg03315344 chr16:75512273 CHST6 0.55 9.25 0.45 3.01e-18 Dupuytren's disease; CRC cis rs9372498 0.536 rs9489458 chr6:118920503 G/A cg18833306 chr6:118973337 C6orf204 0.44 5.71 0.3 2.54e-8 Diastolic blood pressure; CRC cis rs6951245 0.554 rs2070118 chr7:1132505 G/A cg23978390 chr7:1156363 C7orf50 0.52 5.87 0.31 1.09e-8 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs9517320 0.534 rs9554478 chr13:99187792 G/A cg07423050 chr13:99094983 FARP1 -0.56 -7.87 -0.4 5.21e-14 Longevity; CRC cis rs1799949 1.000 rs8176233 chr17:41219804 T/C cg25072359 chr17:41440525 NA 0.47 7.04 0.36 1.11e-11 Menopause (age at onset); CRC cis rs9660180 0.967 rs12044597 chr1:1708801 A/G cg05132306 chr1:1846340 CALML6 -0.44 -6.8 -0.35 4.84e-11 Body mass index; CRC cis rs853679 0.517 rs9393888 chr6:28059217 G/C cg06470822 chr6:28175283 NA 1.0 13.31 0.59 1.27e-32 Depression; CRC cis rs9522267 0.535 rs9522296 chr13:112234340 C/T cg26182253 chr13:112236782 NA -0.31 -6.25 -0.33 1.24e-9 Hepatitis; CRC cis rs7618915 0.547 rs13065019 chr3:52685244 T/C cg08222913 chr3:52553049 STAB1 -0.34 -6.16 -0.32 2.14e-9 Bipolar disorder; CRC cis rs911119 0.913 rs6106685 chr20:23581612 A/C cg16589663 chr20:23618590 CST3 0.42 5.81 0.3 1.51e-8 Chronic kidney disease; CRC cis rs2797160 0.967 rs1343120 chr6:125992810 A/G cg05901451 chr6:126070800 HEY2 -0.38 -5.83 -0.31 1.33e-8 Endometrial cancer; CRC cis rs1153858 0.943 rs7402632 chr15:45701913 A/T cg21132104 chr15:45694354 SPATA5L1 0.6 8.5 0.42 6.56e-16 Homoarginine levels; CRC cis rs2991971 0.810 rs12738318 chr1:45929589 A/G cg24296786 chr1:45957014 TESK2 -0.45 -6.46 -0.34 3.87e-10 High light scatter reticulocyte count; CRC cis rs6912958 0.559 rs107689 chr6:88069333 G/T cg12350822 chr6:88032061 C6orf162;GJB7 0.44 8.96 0.44 2.38e-17 Monocyte percentage of white cells; CRC cis rs10791323 0.604 rs2723598 chr11:133711652 G/A cg00579200 chr11:133705235 NA -0.39 -5.65 -0.3 3.48e-8 Childhood ear infection; CRC cis rs7647973 0.961 rs11130187 chr3:49307872 T/C cg07690219 chr3:49449608 TCTA;RHOA -0.49 -5.69 -0.3 2.76e-8 Menarche (age at onset); CRC cis rs7772486 0.623 rs735535 chr6:146036829 C/T cg23711669 chr6:146136114 FBXO30 -0.65 -10.7 -0.51 3.9e-23 Lobe attachment (rater-scored or self-reported); CRC cis rs79057730 0.528 rs4719313 chr7:822501 C/T cg06242242 chr7:766104 PRKAR1B;HEATR2 0.65 6.44 0.33 4.13e-10 Initial pursuit acceleration; CRC cis rs1799949 1.000 rs33945274 chr17:41280073 G/A cg01879757 chr17:41196368 BRCA1 -0.43 -6.61 -0.34 1.54e-10 Menopause (age at onset); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg10624583 chr12:53440492 TENC1 0.49 7.35 0.38 1.57e-12 Response to antipsychotic treatment; CRC cis rs75920871 0.528 rs7124872 chr11:116927951 C/T cg20608306 chr11:116969690 SIK3 0.34 6.43 0.33 4.49e-10 Subjective well-being; CRC cis rs7737355 0.812 rs11242084 chr5:130935777 T/C cg25547332 chr5:131281432 NA 0.39 5.95 0.31 6.82e-9 Life satisfaction; CRC cis rs5758511 0.680 rs56111723 chr22:42664883 T/A cg00645731 chr22:42541494 CYP2D7P1 0.62 9.52 0.46 3.84e-19 Birth weight; CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg16402443 chr7:2598526 IQCE 0.45 7.18 0.37 4.58e-12 Obesity-related traits; CRC cis rs853679 0.550 rs1233701 chr6:28168726 C/G cg15786705 chr6:28176104 NA -0.82 -12.03 -0.55 7.19e-28 Depression; CRC cis rs7572644 0.582 rs7570730 chr2:28022675 G/A cg27432699 chr2:27873401 GPN1 0.45 5.66 0.3 3.27e-8 Response to carboplatin and paclitaxel in ovarian cancer (Caspase 3/7 EC50); CRC cis rs4481887 0.927 rs9651176 chr1:248447343 A/G cg13385794 chr1:248469461 NA 0.39 6.93 0.36 2.28e-11 Common traits (Other); CRC cis rs8044868 0.530 rs9932951 chr16:72075341 A/G cg23815491 chr16:72088622 HP 0.48 6.81 0.35 4.56e-11 Body mass index (change over time) in cancer or chronic obstructive pulmonary disease;Body mass index (change over time) in cancer; CRC cis rs9308731 0.644 rs7602904 chr2:111880600 C/T cg04202892 chr2:111875749 ACOXL 0.43 7.04 0.36 1.11e-11 Chronic lymphocytic leukemia; CRC cis rs1568889 1.000 rs11602768 chr11:28351786 G/A cg06544937 chr11:28130018 METT5D1;KIF18A 0.76 9.74 0.47 7.5599999999999994e-20 Bipolar disorder; CRC cis rs2050392 0.894 rs303430 chr10:30706235 C/A cg25182066 chr10:30743637 MAP3K8 -0.4 -5.77 -0.3 1.83e-8 Inflammatory bowel disease; CRC cis rs17376456 0.877 rs10059230 chr5:93450347 A/G cg09848695 chr5:92956644 FAM172A;MIR2277 0.63 6.14 0.32 2.37e-9 Diabetic retinopathy; CRC cis rs10751667 0.666 rs6597958 chr11:978087 C/T ch.11.42038R chr11:967971 AP2A2 0.58 9.98 0.48 1.16e-20 Alzheimer's disease (late onset); CRC cis rs3806843 1.000 rs1548700 chr5:140164889 A/T cg16607685 chr5:140181889 PCDHA2;PCDHA1;PCDHA3 -0.27 -6.25 -0.33 1.25e-9 Depressive symptoms (multi-trait analysis); CRC trans rs916888 0.821 rs199506 chr17:44859031 A/G cg22433210 chr17:43662623 NA -0.83 -9.03 -0.45 1.48e-17 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs6933660 0.512 rs9383905 chr6:151804296 C/T cg10883421 chr6:151773342 RMND1;C6orf211 0.62 6.89 0.36 2.77e-11 Menarche (age at onset); CRC cis rs7542091 0.648 rs688464 chr1:209992539 C/T cg23283495 chr1:209979779 IRF6 -0.36 -6.55 -0.34 2.25e-10 Monobrow; CRC cis rs798554 0.797 rs1182183 chr7:2873136 C/T cg09658497 chr7:2847517 GNA12 -0.4 -5.61 -0.3 4.29e-8 Height; CRC cis rs501120 0.925 rs1746052 chr10:44778546 G/T cg09554077 chr10:44749378 NA -0.81 -10.9 -0.51 8.26e-24 Coronary artery disease;Coronary heart disease; CRC cis rs8044868 0.586 rs2070937 chr16:72089740 A/G cg06172871 chr16:72088244 HP 0.43 6.36 0.33 6.92e-10 Body mass index (change over time) in cancer or chronic obstructive pulmonary disease;Body mass index (change over time) in cancer; CRC cis rs2836974 0.932 rs6517523 chr21:40557332 T/C cg11890956 chr21:40555474 PSMG1 1.09 18.38 0.71 2.07e-52 Cognitive function; CRC cis rs28386778 0.897 rs6504185 chr17:61848792 A/G cg06601766 chr17:61851465 DDX42;CCDC47 0.45 6.1 0.32 3.06e-9 Prudent dietary pattern; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg16931877 chr3:32726605 CNOT10 0.38 6.63 0.34 1.34e-10 Liver disease severity in Alagille syndrome; CRC cis rs72772090 0.539 rs17405676 chr5:96182615 C/T cg17330273 chr5:96107758 CAST;ERAP1 -0.63 -6.32 -0.33 8.73e-10 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg11688874 chr10:28822482 WAC 0.48 6.91 0.36 2.54e-11 Response to antipsychotic treatment; CRC cis rs2969070 0.965 rs9691234 chr7:2508415 A/G cg03277898 chr7:2518824 NA -0.43 -6.15 -0.32 2.2e-9 Diastolic blood pressure; CRC cis rs847577 0.609 rs6465657 chr7:97816327 C/T cg24562669 chr7:97807699 LMTK2 0.79 17.64 0.7 1.72e-49 Breast cancer; CRC cis rs10479542 0.784 rs7703730 chr5:178986632 C/A cg22764044 chr5:178986830 RUFY1 -0.34 -5.69 -0.3 2.79e-8 Lung cancer; CRC trans rs7615952 0.611 rs7632305 chr3:125634767 C/T cg07211511 chr3:129823064 LOC729375 -1.1 -12.97 -0.58 2.41e-31 Blood pressure (smoking interaction); CRC cis rs7223966 0.921 rs11655493 chr17:61733052 C/T cg23090583 chr17:61904693 PSMC5;FTSJ3 0.49 6.1 0.32 2.95e-9 Hip circumference adjusted for BMI;Body mass index; CRC cis rs6933660 0.646 rs3736176 chr6:151773320 T/A cg14262678 chr6:151773367 RMND1;C6orf211 0.59 10.05 0.48 6.89e-21 Menarche (age at onset); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg18890864 chr5:131826458 IRF1 0.4 6.21 0.32 1.58e-9 Intelligence (multi-trait analysis); CRC cis rs7258465 1.000 rs10409505 chr19:18590251 C/G cg06953865 chr19:18549723 ISYNA1 -0.38 -5.8 -0.3 1.55e-8 Breast cancer; CRC cis rs10504229 0.639 rs11781834 chr8:58133422 C/T cg02290350 chr8:58132656 NA -0.57 -7.92 -0.4 3.81e-14 Developmental language disorder (linguistic errors); CRC cis rs6860806 0.661 rs334902 chr5:131586559 C/G cg18301423 chr5:131593218 PDLIM4 0.37 6.78 0.35 5.42e-11 Breast cancer; CRC cis rs798766 1.000 rs798766 chr4:1734239 C/T cg02089348 chr4:1724449 TMEM129;TACC3 0.4 5.73 0.3 2.21e-8 Bladder cancer;Urinary bladder cancer; CRC cis rs7591163 1.000 rs7591163 chr2:228715375 C/T cg08034379 chr2:228736324 WDR69 -0.54 -7.27 -0.37 2.62e-12 Blood pressure; CRC cis rs1348850 0.519 rs4144275 chr2:178523368 C/T cg27490568 chr2:178487706 NA 0.38 5.64 0.3 3.69e-8 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs13108904 0.967 rs13150571 chr4:1278636 C/G cg02018176 chr4:1364513 KIAA1530 0.48 7.93 0.4 3.43e-14 Obesity-related traits; CRC cis rs1862618 0.853 rs252919 chr5:56124111 T/C cg18230493 chr5:56204884 C5orf35 -0.71 -9.21 -0.45 4.03e-18 Initial pursuit acceleration; CRC cis rs8103278 0.507 rs3745802 chr19:46271177 G/T cg02376097 chr19:46275166 DMPK 0.38 6.02 0.32 4.63e-9 Coronary artery disease; CRC cis rs490234 0.702 rs2416964 chr9:128360413 C/T cg14078157 chr9:128172775 NA -0.38 -6.32 -0.33 8.54e-10 Mean arterial pressure; CRC cis rs7246657 0.943 rs10426666 chr19:37828514 C/G cg23950597 chr19:37808831 NA -0.54 -6.5 -0.34 2.93e-10 Coronary artery calcification; CRC trans rs61931739 0.500 rs9919726 chr12:34510783 A/G cg26384229 chr12:38710491 ALG10B 0.62 9.17 0.45 5.2e-18 Morning vs. evening chronotype; CRC cis rs8060686 0.858 rs13334918 chr16:67901343 A/G cg07125278 chr16:67683757 RLTPR -0.49 -6.77 -0.35 5.9e-11 HDL cholesterol;Metabolic syndrome; CRC cis rs2860975 1.000 rs7920659 chr10:96767924 T/C cg09036531 chr10:96991505 NA -0.43 -5.95 -0.31 6.79e-9 Immune response to smallpox vaccine (IL-6); CRC cis rs9309711 0.666 rs4321399 chr2:3481659 G/A cg10845886 chr2:3471009 TTC15 -0.45 -7.21 -0.37 3.93e-12 Neurofibrillary tangles; CRC cis rs9287719 0.601 rs6751436 chr2:10723862 C/T cg00105475 chr2:10696890 NA 0.46 7.17 0.37 5.09e-12 Prostate cancer; CRC cis rs6912958 1.000 rs9294379 chr6:88152535 C/A cg12350822 chr6:88032061 C6orf162;GJB7 -0.36 -6.76 -0.35 6.38e-11 Monocyte percentage of white cells; CRC cis rs1552244 0.572 rs6783705 chr3:10164783 A/G cg02579736 chr3:10068473 FANCD2;CIDECP 1.01 11.58 0.54 2.98e-26 Alzheimer's disease; CRC cis rs10479542 0.896 rs4701131 chr5:178982446 A/G cg05457628 chr5:178986728 RUFY1 0.43 7.27 0.37 2.58e-12 Lung cancer; CRC cis rs4604732 0.631 rs12038880 chr1:247624603 A/G cg12754571 chr1:247694271 LOC148824;OR2C3 0.46 6.11 0.32 2.86e-9 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CRC cis rs9916302 0.706 rs4516267 chr17:37471482 G/T cg00129232 chr17:37814104 STARD3 0.57 7.22 0.37 3.66e-12 Glomerular filtration rate (creatinine); CRC cis rs2243480 1.000 rs34702770 chr7:65344823 T/C cg18252515 chr7:66147081 NA -1.17 -13.57 -0.6 1.26e-33 Diabetic kidney disease; CRC trans rs820077 0.557 rs6457807 chr6:35142899 T/C cg23173586 chr14:20945319 PNP -0.29 -6.04 -0.32 4.09e-9 Systemic lupus erythematosus; CRC cis rs9928842 0.771 rs2870471 chr16:75274282 A/G cg08657710 chr16:75258780 CTRB1 0.47 6.1 0.32 2.93e-9 Alcoholic chronic pancreatitis; CRC cis rs9914988 0.725 rs66531973 chr17:27125993 G/T cg16670446 chr17:27188758 MIR451;MIR144 0.55 8.56 0.43 4.49e-16 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs2576037 0.501 rs8089938 chr18:44459497 C/T cg23996704 chr18:44553084 KATNAL2 -0.3 -5.9 -0.31 8.93e-9 Personality dimensions; CRC cis rs2070488 0.965 rs9877282 chr3:38541452 A/G cg01465620 chr3:38496096 LOC100128640;ACVR2B -0.91 -16.97 -0.68 7.73e-47 Electrocardiographic conduction measures; CRC cis rs4972806 0.668 rs2072588 chr2:177042930 G/C cg14324370 chr2:177042789 NA 0.81 13.12 0.59 6.36e-32 IgG glycosylation; CRC cis rs17270561 0.636 rs9358880 chr6:25743161 C/T cg17691542 chr6:26056736 HIST1H1C 0.72 9.24 0.45 3.07e-18 Iron status biomarkers; CRC cis rs4728302 0.869 rs11770927 chr7:133593126 G/A cg03336402 chr7:133662267 EXOC4 -0.45 -6.56 -0.34 2.04e-10 Intelligence;Intelligence (multi-trait analysis); CRC cis rs2153535 0.580 rs1832101 chr6:8460177 A/G cg21535247 chr6:8435926 SLC35B3 0.5 7.55 0.38 4.28e-13 Motion sickness; CRC cis rs7725052 0.609 rs9292778 chr5:40443296 A/G cg09067459 chr5:40385259 NA -0.4 -6.6 -0.34 1.68e-10 Pediatric autoimmune diseases; CRC cis rs432925 0.600 rs214247 chr16:349221 A/G cg08823186 chr16:347294 AXIN1 0.42 6.42 0.33 4.82e-10 Morning vs. evening chronotype; CRC trans rs10983614 1.000 rs7867776 chr9:120072627 A/G cg06446895 chr17:79829189 ARHGDIA 0.48 6.69 0.35 9.49e-11 Survival in pancreatic cancer; CRC cis rs514406 0.525 rs269291 chr1:53189297 C/T cg08859206 chr1:53392774 SCP2 -0.42 -6.43 -0.33 4.36e-10 Monocyte count; CRC cis rs9916302 0.904 rs68178216 chr17:37526241 A/C cg00129232 chr17:37814104 STARD3 0.53 7.81 0.4 7.65e-14 Glomerular filtration rate (creatinine); CRC cis rs11098499 0.954 rs10008392 chr4:120318839 G/A cg24375607 chr4:120327624 NA 0.49 7.45 0.38 8.47e-13 Corneal astigmatism; CRC cis rs3809566 0.963 rs3809565 chr15:63333619 A/G cg05507819 chr15:63340323 TPM1 0.39 5.79 0.3 1.66e-8 Platelet count; CRC cis rs10493773 0.609 rs6689168 chr1:86174232 G/T cg17807903 chr1:86174739 ZNHIT6 -0.65 -17.68 -0.7 1.16e-49 Urate levels in overweight individuals; CRC trans rs561341 0.609 rs7209493 chr17:30197323 A/G cg20587970 chr11:113659929 NA 0.7 8.85 0.44 5.59e-17 Hip circumference adjusted for BMI; CRC cis rs561341 0.825 rs2008368 chr17:30347397 T/C cg19193384 chr17:30244184 NA -0.67 -7.78 -0.39 9.36e-14 Hip circumference adjusted for BMI; CRC cis rs7726839 0.540 rs7558 chr5:660491 C/T cg16447950 chr5:562315 NA -0.77 -10.13 -0.49 3.62e-21 Obesity-related traits; CRC trans rs561341 1.000 rs7214017 chr17:30332220 T/C cg20587970 chr11:113659929 NA -1.19 -17.01 -0.68 5.15e-47 Hip circumference adjusted for BMI; CRC cis rs4862750 0.914 rs1346127 chr4:187876389 C/T cg03647317 chr4:187891568 NA 0.52 9.73 0.47 8.03e-20 Lobe attachment (rater-scored or self-reported); CRC cis rs9355610 0.609 rs9366076 chr6:167373708 C/T cg23791538 chr6:167370224 RNASET2 0.53 7.42 0.38 9.99e-13 Graves' disease; CRC trans rs1814175 0.817 rs10839351 chr11:49758153 C/T cg03929089 chr4:120376271 NA -0.96 -18.51 -0.71 6.51e-53 Height; CRC cis rs8062405 0.755 rs2077031 chr16:28603168 T/A cg00198680 chr16:28758506 NA 0.35 5.73 0.3 2.26e-8 Cognitive ability (multi-trait analysis);Cognitive ability; CRC trans rs6539288 0.803 rs10778517 chr12:107341664 G/T cg26868354 chr6:35699952 LOC285847 -0.45 -6.21 -0.32 1.56e-9 Total body bone mineral density; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg26566046 chr12:80083628 PAWR 0.42 6.71 0.35 8.63e-11 Liver disease severity in Alagille syndrome; CRC cis rs10871290 0.650 rs3760055 chr16:74490529 G/A cg01733217 chr16:74700730 RFWD3 0.75 11.36 0.53 1.95e-25 Breast cancer; CRC cis rs4713118 0.616 rs9348789 chr6:28025486 C/T cg25164649 chr6:28176230 NA 0.65 8.57 0.43 4.18e-16 Parkinson's disease; CRC cis rs4076764 0.515 rs4657268 chr1:163376507 A/T cg06092702 chr1:163392909 NA -0.39 -6.05 -0.32 3.87e-9 Motion sickness; CRC cis rs2204008 0.805 rs7296063 chr12:37964775 T/G cg26384229 chr12:38710491 ALG10B 0.69 8.99 0.44 1.97e-17 Bladder cancer; CRC cis rs977987 0.806 rs35787595 chr16:75466847 G/C cg03315344 chr16:75512273 CHST6 0.55 9.12 0.45 7.56e-18 Dupuytren's disease; CRC trans rs7613875 0.620 rs3774734 chr3:50108792 C/A cg21659725 chr3:3221576 CRBN -0.44 -6.44 -0.33 4.32e-10 Body mass index; CRC cis rs3091242 0.933 rs34933589 chr1:25788198 T/C cg02931644 chr1:25747376 RHCE -0.34 -5.8 -0.3 1.52e-8 Erythrocyte sedimentation rate; CRC cis rs4072980 0.524 rs28477803 chr1:38398694 C/T cg12658694 chr1:38397304 INPP5B 0.51 7.16 0.37 5.17e-12 Coronary artery disease; CRC cis rs1218582 0.741 rs11264283 chr1:154869552 A/G cg09359103 chr1:154839909 KCNN3 -0.71 -12.54 -0.57 9.61e-30 Prostate cancer; CRC cis rs9322193 0.607 rs7764677 chr6:150227333 C/T cg13206674 chr6:150067644 NUP43 0.43 5.64 0.3 3.57e-8 Lung cancer; CRC cis rs951366 0.764 rs708725 chr1:205744138 G/T cg07157834 chr1:205819609 PM20D1 0.78 12.0 0.55 9.33e-28 Menarche (age at onset); CRC cis rs6424115 1.000 rs7519554 chr1:24154566 T/A cg24699146 chr1:24152579 HMGCL -0.32 -5.67 -0.3 3.1e-8 Immature fraction of reticulocytes; CRC cis rs6951245 1.000 rs77760339 chr7:1083927 G/T cg03188948 chr7:1209495 NA 0.63 6.54 0.34 2.29e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs2197308 0.605 rs2387437 chr12:37919367 T/C cg26384229 chr12:38710491 ALG10B 0.65 8.96 0.44 2.52e-17 Morning vs. evening chronotype; CRC cis rs7727544 0.571 rs12521097 chr5:131575338 G/A cg18758796 chr5:131593413 PDLIM4 0.34 6.32 0.33 8.46e-10 Blood metabolite levels; CRC cis rs1904096 0.506 rs10024642 chr4:95179295 A/G cg11021082 chr4:95130006 SMARCAD1 -0.5 -7.51 -0.38 5.56e-13 Type 2 diabetes; CRC cis rs860772 0.500 rs857683 chr1:158574585 G/A cg12129480 chr1:158549410 OR10X1 -0.26 -5.63 -0.3 3.82e-8 Lymphocyte percentage of white cells; CRC cis rs6502050 0.835 rs7502676 chr17:80093433 C/G cg22110888 chr17:80059540 CCDC57 0.4 6.35 0.33 7.28e-10 Life satisfaction; CRC cis rs2573652 0.723 rs2573655 chr15:100515709 A/C cg00587665 chr15:100533223 ADAMTS17 -0.45 -7.46 -0.38 7.69e-13 Height; CRC trans rs9929218 0.911 rs4783685 chr16:68834107 C/T cg04657470 chr2:198365150 HSPE1;HSPD1 -0.8 -11.45 -0.53 8.9e-26 Colorectal cancer; CRC cis rs11155671 0.530 rs9371542 chr6:150213085 A/T cg13206674 chr6:150067644 NUP43 0.52 7.15 0.37 5.81e-12 Testicular germ cell tumor; CRC cis rs7246657 0.882 rs59224125 chr19:37963205 T/C cg23950597 chr19:37808831 NA -0.49 -6.06 -0.32 3.7e-9 Coronary artery calcification; CRC cis rs10927875 0.541 rs1739844 chr1:16343322 T/C cg10494257 chr1:16342123 HSPB7 0.45 6.27 0.33 1.1e-9 Dilated cardiomyopathy; CRC cis rs554111 0.509 rs495522 chr1:21105994 C/T cg02927042 chr1:21476669 EIF4G3 -0.38 -5.61 -0.3 4.25e-8 Facial morphology (factor 17, height of vermillion upper lip); CRC cis rs939584 1.000 rs4429506 chr2:652576 C/A cg03610516 chr2:642275 NA 0.41 5.92 0.31 8.24e-9 Body mass index; CRC cis rs9322193 0.923 rs2297932 chr6:150039361 C/G cg07701084 chr6:150067640 NUP43 0.56 8.2 0.41 5.45e-15 Lung cancer; CRC cis rs736801 0.808 rs2248116 chr5:131804347 C/A cg14196790 chr5:131705035 SLC22A5 -0.35 -5.77 -0.3 1.79e-8 Breast cancer;Mosquito bite size; CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg08715135 chr8:126442747 TRIB1 -0.53 -6.47 -0.34 3.6e-10 Diisocyanate-induced asthma; CRC cis rs1707322 0.691 rs11211174 chr1:46220816 C/G cg03146154 chr1:46216737 IPP 0.68 9.94 0.48 1.59e-20 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs4409675 0.597 rs1467464 chr1:28211650 T/C cg23691781 chr1:28212827 C1orf38 0.35 8.03 0.4 1.73e-14 Corneal astigmatism; CRC cis rs2228479 0.850 rs11645240 chr16:89837326 T/C cg06558623 chr16:89946397 TCF25 1.13 10.76 0.51 2.47e-23 Skin colour saturation; CRC cis rs6502050 0.787 rs7222326 chr17:80057272 T/C cg09264619 chr17:80180166 NA 0.36 5.86 0.31 1.11e-8 Life satisfaction; CRC trans rs11088226 1.000 rs2833889 chr21:33927768 G/T cg09050820 chr6:167586206 TCP10L2 -0.6 -6.83 -0.35 4.07e-11 Gastritis; CRC cis rs3789045 0.913 rs55678522 chr1:204573481 G/A cg17419461 chr1:204415978 PIK3C2B -0.53 -7.54 -0.38 4.48e-13 Educational attainment (college completion); CRC cis rs11123610 0.520 rs35752035 chr2:3721353 G/C cg25251562 chr2:3704773 ALLC -0.48 -6.07 -0.32 3.62e-9 Response to inhaled corticosteroid treatment in asthma (change in FEV1); CRC trans rs2018683 0.600 rs717891 chr7:29000374 C/T cg19402173 chr7:128379420 CALU -0.48 -6.57 -0.34 2.02e-10 Response to irinotecan and platinum-based chemotherapy in non-small-cell lung cancer; CRC cis rs55675132 0.510 rs6696332 chr1:115300370 T/C cg12756093 chr1:115239321 AMPD1 0.54 6.23 0.32 1.42e-9 Schizophrenia; CRC cis rs9322193 0.962 rs9322206 chr6:149962617 T/C cg07701084 chr6:150067640 NUP43 0.48 6.76 0.35 6.28e-11 Lung cancer; CRC trans rs11722228 0.549 rs2241488 chr4:10101131 T/C cg26043149 chr18:55253948 FECH 1.13 17.08 0.69 2.71e-47 Gout;Urate levels;Serum uric acid levels; CRC cis rs4319547 0.656 rs1553179 chr12:122831073 A/G cg23029597 chr12:123009494 RSRC2 -0.51 -6.31 -0.33 8.95e-10 Body mass index; CRC trans rs6951245 1.000 rs111899361 chr7:1112348 C/T cg13565492 chr6:43139072 SRF -0.72 -7.43 -0.38 9.33e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs4474465 0.688 rs7927494 chr11:78280578 G/A cg27205649 chr11:78285834 NARS2 0.52 6.57 0.34 1.98e-10 Alzheimer's disease (survival time); CRC trans rs875971 0.660 rs2191268 chr7:66110224 C/T cg04516253 chr19:40596853 ZNF780A -0.38 -6.04 -0.32 4.08e-9 Aortic root size; CRC cis rs3812049 0.784 rs1560637 chr5:127448066 A/C cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.72 8.71 0.43 1.49e-16 Lymphocyte counts;Red cell distribution width; CRC cis rs9341808 0.718 rs11962614 chr6:80823306 A/T cg08355045 chr6:80787529 NA 0.43 6.9 0.36 2.64e-11 Sitting height ratio; CRC cis rs911555 0.723 rs7149767 chr14:103863545 G/A cg12935359 chr14:103987150 CKB 0.55 8.8 0.44 7.72e-17 Intelligence (multi-trait analysis); CRC cis rs11098499 0.863 rs3775858 chr4:120486028 A/G cg24375607 chr4:120327624 NA 0.48 7.24 0.37 3.13e-12 Corneal astigmatism; CRC trans rs7027930 0.520 rs4384034 chr9:607005 C/G cg27061366 chr19:13044373 FARSA 0.51 6.29 0.33 1e-9 Pulmonary function decline; CRC cis rs12762955 0.561 rs10752022 chr10:1043798 C/T cg26597838 chr10:835615 NA -0.45 -6.09 -0.32 3.2e-9 Response to angiotensin II receptor blocker therapy; CRC cis rs10751667 0.643 rs10902245 chr11:953014 C/T cg06064525 chr11:970664 AP2A2 0.33 6.77 0.35 6.02e-11 Alzheimer's disease (late onset); CRC cis rs4638749 0.677 rs13023102 chr2:108837663 C/T cg25838818 chr2:108905173 SULT1C2 -0.33 -5.61 -0.3 4.35e-8 Blood pressure; CRC cis rs875971 0.862 rs778720 chr7:65846275 A/C cg18252515 chr7:66147081 NA 0.41 6.04 0.32 4.12e-9 Aortic root size; CRC cis rs7605378 0.528 rs281767 chr2:200823281 C/A cg17644776 chr2:200775616 C2orf69 0.43 6.75 0.35 6.49e-11 Osteoporosis; CRC cis rs9513593 1.000 rs747848 chr13:100036182 C/T cg21788972 chr13:99853209 UBAC2 0.43 5.6 0.3 4.5e-8 Psoriasis; CRC cis rs2243480 1.000 rs73142121 chr7:65311206 C/T cg18252515 chr7:66147081 NA -1.17 -13.57 -0.6 1.26e-33 Diabetic kidney disease; CRC cis rs875971 0.862 rs12698526 chr7:65969105 T/C cg12463550 chr7:65579703 CRCP 0.46 6.27 0.33 1.12e-9 Aortic root size; CRC cis rs896854 0.517 rs1011796 chr8:95951273 A/G cg16049864 chr8:95962084 TP53INP1 0.46 7.25 0.37 2.97e-12 Type 2 diabetes; CRC cis rs2204008 0.577 rs11520050 chr12:38051839 G/A cg26384229 chr12:38710491 ALG10B 0.69 9.17 0.45 5.4e-18 Bladder cancer; CRC cis rs11641365 1.000 rs11641365 chr16:88773893 A/G cg27087555 chr16:88793112 FAM38A 0.5 5.69 0.3 2.77e-8 Autism spectrum disorder-related traits; CRC cis rs1799949 1.000 rs12516 chr17:41196408 G/A cg05368731 chr17:41323189 NBR1 0.68 10.35 0.5 6.24e-22 Menopause (age at onset); CRC cis rs4713118 0.615 rs57252182 chr6:27720249 C/A cg25164649 chr6:28176230 NA 0.54 7.8 0.4 8.06e-14 Parkinson's disease; CRC cis rs2408955 0.541 rs11168428 chr12:48547128 A/G cg15465823 chr12:48382534 COL2A1 -0.39 -6.41 -0.33 4.9e-10 Glycated hemoglobin levels; CRC cis rs12701220 0.503 rs13222294 chr7:1172969 G/A cg00990874 chr7:1149470 C7orf50 -0.62 -7.7 -0.39 1.59e-13 Bronchopulmonary dysplasia; CRC cis rs2832191 0.791 rs9983651 chr21:30491227 T/A cg24692254 chr21:30365293 RNF160 -0.69 -11.85 -0.55 3.36e-27 Dental caries; CRC cis rs6860806 0.507 rs274570 chr5:131713226 C/T cg20512303 chr5:131592959 PDLIM4 -0.4 -6.83 -0.35 4.06e-11 Breast cancer; CRC trans rs7395662 0.674 rs7124275 chr11:48162305 C/T cg21153622 chr11:89784906 NA -0.41 -6.27 -0.33 1.12e-9 HDL cholesterol; CRC cis rs6940638 0.688 rs9461335 chr6:27138529 C/A cg12292205 chr6:26970375 C6orf41 -0.47 -6.48 -0.34 3.35e-10 Intelligence (multi-trait analysis); CRC cis rs4713118 0.955 rs9468206 chr6:27690453 G/T cg15786705 chr6:28176104 NA 0.49 6.49 0.34 3.18e-10 Parkinson's disease; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg11992237 chr8:74791052 UBE2W 0.42 6.97 0.36 1.69e-11 Liver disease severity in Alagille syndrome; CRC cis rs2952156 0.920 rs2517954 chr17:37843550 T/C cg11212589 chr17:38028394 ZPBP2 0.35 5.94 0.31 7.37e-9 Asthma; CRC cis rs950169 0.840 rs72748702 chr15:84915246 A/G cg17507749 chr15:85114479 UBE2QP1 0.75 10.95 0.52 5.53e-24 Schizophrenia; CRC cis rs9905704 0.846 rs35082135 chr17:56939694 A/G cg12560992 chr17:57184187 TRIM37 0.57 8.18 0.41 6.1e-15 Testicular germ cell tumor; CRC cis rs9457247 0.902 rs366938 chr6:167403538 T/C cg23791538 chr6:167370224 RNASET2 -0.38 -5.94 -0.31 7.07e-9 Crohn's disease; CRC trans rs10983614 1.000 rs7867776 chr9:120072627 A/G cg06463759 chr7:128502823 ATP6V1F 0.47 6.65 0.34 1.19e-10 Survival in pancreatic cancer; CRC cis rs7429990 0.965 rs7642590 chr3:48099750 G/A cg11946769 chr3:48343235 NME6 -0.47 -6.01 -0.31 5.01e-9 Educational attainment (years of education); CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg10310846 chr10:28821381 WAC 0.45 6.02 0.31 4.75e-9 Anxiety disorder; CRC cis rs17826219 0.706 rs2322197 chr17:29105805 T/C cg13385521 chr17:29058706 SUZ12P 0.71 8.2 0.41 5.37e-15 Body mass index; CRC cis rs6424115 0.830 rs2503000 chr1:24197898 C/G cg15997130 chr1:24165203 NA 0.72 10.69 0.51 4.31e-23 Immature fraction of reticulocytes; CRC trans rs877282 0.945 rs12767287 chr10:787310 A/G cg22713356 chr15:30763199 NA 1.32 16.01 0.66 4.44e-43 Uric acid levels; CRC cis rs13064411 0.660 rs3829889 chr3:113015464 G/A cg18753928 chr3:113234510 CCDC52 -0.59 -7.77 -0.39 1.01e-13 Response to simvastatin treatment (PCSK9 protein level change); CRC cis rs7945705 0.837 rs10769981 chr11:9024460 T/C cg12365402 chr11:9010492 NRIP3 0.54 8.85 0.44 5.45e-17 Hemoglobin concentration; CRC cis rs9611565 0.694 rs7285041 chr22:41829149 G/T cg06481639 chr22:41940642 POLR3H 0.53 5.78 0.3 1.72e-8 Vitiligo; CRC cis rs4240897 0.935 rs3766744 chr1:12043717 G/A cg13216073 chr1:12042593 MFN2 0.62 10.45 0.5 2.87e-22 Tuberculosis; CRC cis rs10504229 0.683 rs56196593 chr8:58141898 G/A cg04204079 chr8:58130323 NA -0.45 -5.75 -0.3 1.99e-8 Developmental language disorder (linguistic errors); CRC cis rs929354 0.742 rs2051877 chr7:157008813 A/T cg17757837 chr7:157058334 UBE3C 0.73 12.35 0.56 4.89e-29 Body mass index; CRC cis rs12325245 0.536 rs35832551 chr16:58591444 G/T cg01472538 chr16:58549086 SETD6 1.06 6.94 0.36 2.05e-11 Schizophrenia; CRC cis rs11148252 0.846 rs1056335 chr13:52989863 C/T cg00495681 chr13:53174319 NA 0.57 8.54 0.43 4.9e-16 Lewy body disease; CRC cis rs950776 0.518 rs3813571 chr15:78832792 G/T cg06917634 chr15:78832804 PSMA4 0.67 10.66 0.51 5.57e-23 Sudden cardiac arrest; CRC cis rs6938 0.534 rs12907898 chr15:75207872 C/T cg09165964 chr15:75287851 SCAMP5 0.61 9.67 0.47 1.25e-19 Breast cancer; CRC cis rs3736485 0.966 rs9920124 chr15:51908942 T/A cg08986416 chr15:51914746 DMXL2 -0.46 -6.53 -0.34 2.57e-10 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs28735056 0.967 rs4799092 chr18:77608203 C/G cg20368463 chr18:77673604 PQLC1 -0.52 -7.97 -0.4 2.55e-14 Schizophrenia; CRC cis rs7615952 0.673 rs3811677 chr3:125648080 G/A cg05084668 chr3:125655381 ALG1L -0.61 -9.2 -0.45 4.25e-18 Blood pressure (smoking interaction); CRC cis rs3204270 0.639 rs62080213 chr17:79642531 C/T cg09655341 chr17:79618100 PDE6G 0.59 6.96 0.36 1.85e-11 Dental caries; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg03662217 chr21:35747882 FAM165B 0.48 6.18 0.32 1.87e-9 Thyroid stimulating hormone; CRC cis rs881375 0.678 rs4836834 chr9:123665901 T/A cg09586646 chr9:123605570 PSMD5;LOC253039 0.47 7.08 0.36 8.85e-12 Rheumatoid arthritis; CRC cis rs28386778 0.897 rs4968663 chr17:61835603 A/T cg06601766 chr17:61851465 DDX42;CCDC47 0.44 5.97 0.31 6.14e-9 Prudent dietary pattern; CRC trans rs35110281 0.777 rs7276215 chr21:44990697 A/G cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.52 8.74 0.43 1.2e-16 Mean corpuscular volume; CRC cis rs6570726 0.935 rs421268 chr6:145845558 A/T cg23711669 chr6:146136114 FBXO30 0.68 12.3 0.56 7.07e-29 Lobe attachment (rater-scored or self-reported); CRC cis rs4936891 0.577 rs12224791 chr11:123919128 A/G cg22125253 chr11:123886957 OR10G4 -0.3 -5.68 -0.3 2.92e-8 Male fertility; CRC cis rs1799949 1.000 rs11656097 chr17:41290613 G/T cg05368731 chr17:41323189 NBR1 0.69 10.5 0.5 1.94e-22 Menopause (age at onset); CRC cis rs1577917 0.740 rs7775864 chr6:86247759 T/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A 0.57 7.87 0.4 5.3e-14 Response to antipsychotic treatment; CRC cis rs9788682 0.947 rs7169584 chr15:78822660 A/T cg06917634 chr15:78832804 PSMA4 -0.46 -5.62 -0.3 4.06e-8 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; CRC cis rs798554 0.591 rs757791 chr7:2867296 A/G cg17321639 chr7:2759063 NA -0.37 -5.66 -0.3 3.34e-8 Height; CRC trans rs561341 0.714 rs547473 chr17:30297560 T/G cg27661571 chr11:113659931 NA -0.77 -9.59 -0.47 2.24e-19 Hip circumference adjusted for BMI; CRC cis rs832540 0.931 rs2591960 chr5:56238811 A/T cg24531977 chr5:56204891 C5orf35 0.6 9.36 0.46 1.31e-18 Coronary artery disease; CRC cis rs4713118 0.666 rs4140646 chr6:27738801 G/A cg06470822 chr6:28175283 NA 0.84 9.56 0.47 2.85e-19 Parkinson's disease; CRC cis rs9788333 0.792 rs34479949 chr13:21895574 G/A cg06138931 chr13:21896616 NA 0.57 9.35 0.46 1.38e-18 Thiazide-induced adverse metabolic effects in hypertensive patients; CRC trans rs7615952 0.932 rs1976458 chr3:125647512 T/G cg02007433 chr3:129722099 NA -0.46 -6.25 -0.33 1.27e-9 Blood pressure (smoking interaction); CRC cis rs2032447 0.966 rs7756117 chr6:26046565 A/G cg12310025 chr6:25882481 NA 0.42 5.99 0.31 5.39e-9 Intelligence (multi-trait analysis); CRC trans rs11989122 0.543 rs4876390 chr8:118808566 A/G cg02216535 chr4:85308929 NA -0.38 -6.39 -0.33 5.74e-10 Height; CRC trans rs6598955 0.671 rs8564 chr1:26605069 T/C cg07461501 chr17:79650226 HGS;ARL16 -0.52 -6.19 -0.32 1.77e-9 Obesity-related traits; CRC cis rs9649213 0.593 rs736754 chr7:97931559 C/T cg21770322 chr7:97807741 LMTK2 0.5 8.23 0.41 4.39e-15 Prostate cancer (SNP x SNP interaction); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg19856771 chr13:42780042 DGKH 0.46 7.55 0.38 4.46e-13 Liver disease severity in Alagille syndrome; CRC trans rs7267979 1.000 rs3002702 chr20:25268920 T/C cg17903999 chr18:56338584 MALT1 -0.42 -7.01 -0.36 1.39e-11 Liver enzyme levels (alkaline phosphatase); CRC cis rs9938149 0.706 rs7198116 chr16:88318648 T/C cg05435882 chr16:88311214 NA -0.46 -6.12 -0.32 2.59e-9 Corneal structure;Central corneal thickness; CRC cis rs2797160 0.967 rs28629380 chr6:126004197 A/G cg05901451 chr6:126070800 HEY2 -0.4 -5.99 -0.31 5.57e-9 Endometrial cancer; CRC cis rs834811 0.583 rs4732179 chr7:135873681 C/T cg01726295 chr7:135938950 NA 0.35 6.06 0.32 3.81e-9 Post-traumatic stress disorder; CRC cis rs208520 0.955 rs9345808 chr6:67008262 C/T cg07460842 chr6:66804631 NA 0.72 8.71 0.43 1.5e-16 Exhaled nitric oxide output; CRC cis rs2112347 0.502 rs34342 chr5:74934213 A/C cg19683494 chr5:74908142 NA -0.53 -5.81 -0.31 1.47e-8 Body mass index (joint analysis main effects and smoking interaction);Waist circumference;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Hip circumference;Body mass index;Body mass index in physically active individuals;Obesity; CRC cis rs6570726 0.764 rs9386125 chr6:145911677 C/T cg13319975 chr6:146136371 FBXO30 -0.44 -6.44 -0.33 4.17e-10 Lobe attachment (rater-scored or self-reported); CRC cis rs7618915 0.571 rs12487445 chr3:52618319 A/C cg18404041 chr3:52824283 ITIH1 -0.43 -8.84 -0.44 5.75e-17 Bipolar disorder; CRC cis rs7177699 0.526 rs7165733 chr15:79123505 G/A cg15571903 chr15:79123663 NA 0.34 6.92 0.36 2.4e-11 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; CRC cis rs5758511 0.633 rs5758690 chr22:42668295 C/G cg00645731 chr22:42541494 CYP2D7P1 0.63 9.54 0.47 3.4e-19 Birth weight; CRC cis rs10971721 0.822 rs10971773 chr9:33898779 G/A cg13495928 chr9:33750294 PRSS3 0.56 5.97 0.31 6.15e-9 Body mass index; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg13692869 chr1:169336982 NME7;BLZF1 0.42 6.27 0.33 1.1e-9 Intelligence (multi-trait analysis); CRC cis rs2257205 0.667 rs74961279 chr17:56904991 C/T cg25885038 chr17:56607967 SEPT4 -0.53 -5.85 -0.31 1.2e-8 Pancreatic cancer; CRC cis rs9549260 0.755 rs7986407 chr13:41179798 A/G cg21288729 chr13:41239152 FOXO1 0.39 5.97 0.31 6.03e-9 Red blood cell count; CRC cis rs2062225 1.000 rs10180604 chr2:111760987 A/G cg11729679 chr2:111877065 BCL2L11 -0.56 -5.64 -0.3 3.67e-8 Monocyte count; CRC cis rs3858526 0.584 rs10769266 chr11:5858460 C/T cg26762873 chr11:5879799 OR52E8 -0.48 -7.16 -0.37 5.39e-12 DNA methylation (variation); CRC cis rs870825 0.929 rs72689254 chr4:185589941 C/T cg07424746 chr4:185654737 MLF1IP -0.6 -5.84 -0.31 1.25e-8 Blood protein levels; CRC cis rs910316 0.967 rs1071989 chr14:75564659 G/T cg08847533 chr14:75593920 NEK9 0.93 17.78 0.7 4.82e-50 Height; CRC cis rs1976403 0.659 rs10799700 chr1:21820968 G/C cg00786952 chr1:21763130 NA 0.49 8.42 0.42 1.15e-15 Liver enzyme levels (alkaline phosphatase); CRC cis rs10504229 1.000 rs66672857 chr8:58179817 G/C cg22535103 chr8:58192502 C8orf71 -0.82 -12.27 -0.56 9.63e-29 Developmental language disorder (linguistic errors); CRC cis rs780096 0.526 rs13472 chr2:27600239 G/A cg02592271 chr2:27665507 KRTCAP3 -0.27 -5.85 -0.31 1.21e-8 Total body bone mineral density; CRC cis rs806215 1.000 rs806215 chr7:127237312 T/C cg25922125 chr7:127225783 GCC1 -0.56 -6.25 -0.33 1.26e-9 Type 2 diabetes; CRC cis rs4604732 0.588 rs4356092 chr1:247632668 G/A cg02104434 chr1:247694406 LOC148824;OR2C3 0.49 7.61 0.39 2.93e-13 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CRC cis rs951366 0.622 rs11580015 chr1:205676088 G/C cg23034840 chr1:205782522 SLC41A1 0.49 6.53 0.34 2.48e-10 Menarche (age at onset); CRC cis rs1847505 0.609 rs9538998 chr13:61571160 A/G cg14094164 chr13:61491000 NA 0.32 6.25 0.33 1.28e-9 Polychlorinated biphenyl levels; CRC cis rs523522 0.962 rs12371550 chr12:120987643 C/T cg12219531 chr12:120966889 COQ5 0.69 9.3 0.46 2.03e-18 High light scatter reticulocyte count; CRC cis rs7221595 0.825 rs10521127 chr17:3978268 A/G cg09695851 chr17:3907499 NA 0.47 6.01 0.31 4.79e-9 Functional impairment in major depressive disorder, bipolar disorder and schizophrenia; CRC cis rs477895 0.838 rs35090903 chr11:64000598 C/T cg23719950 chr11:63933701 MACROD1 -0.61 -7.46 -0.38 7.6e-13 Mean platelet volume; CRC cis rs951366 0.789 rs823094 chr1:205689807 G/T cg07167872 chr1:205819463 PM20D1 -0.72 -11.28 -0.53 3.75e-25 Menarche (age at onset); CRC cis rs4237845 0.837 rs7954957 chr12:58299250 C/T cg00677455 chr12:58241039 CTDSP2 0.52 7.55 0.38 4.24e-13 Intelligence (multi-trait analysis); CRC cis rs2739330 0.828 rs2186366 chr22:24254113 A/G cg24846343 chr22:24311635 DDTL -0.8 -14.27 -0.62 2.69e-36 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs4561483 0.801 rs33660 chr16:11961858 A/G cg08843971 chr16:11963173 GSPT1 -0.61 -9.62 -0.47 1.8e-19 Testicular germ cell tumor; CRC cis rs77861329 1.000 rs352149 chr3:52209530 C/A cg08692210 chr3:52188851 WDR51A 0.83 7.81 0.4 7.57e-14 Macrophage inflammatory protein 1b levels; CRC trans rs3942852 0.568 rs1039484 chr11:48097948 A/G cg03929089 chr4:120376271 NA -0.6 -8.23 -0.41 4.37e-15 Acute lymphoblastic leukemia (childhood); CRC cis rs25645 0.502 rs9895948 chr17:38108363 T/C cg26162295 chr17:38119207 GSDMA -0.34 -5.67 -0.3 3.09e-8 Myeloid white cell count; CRC cis rs2415984 0.579 rs12147928 chr14:46972569 C/T cg14871534 chr14:47121158 RPL10L 0.4 6.18 0.32 1.91e-9 Number of children ever born; CRC trans rs1814175 0.587 rs7937757 chr11:49978342 G/A cg15704280 chr7:45808275 SEPT13 -0.94 -16.88 -0.68 1.75e-46 Height; CRC cis rs2153535 0.580 rs1932284 chr6:8477694 A/T cg07606381 chr6:8435919 SLC35B3 0.68 10.89 0.51 8.87e-24 Motion sickness; CRC cis rs1865760 0.713 rs2013063 chr6:25994098 C/T cg17691542 chr6:26056736 HIST1H1C 0.55 8.51 0.42 6.25e-16 Height; CRC cis rs9488822 0.676 rs1556857 chr6:116325559 T/C cg15226275 chr6:116381976 FRK 0.3 8.5 0.42 6.55e-16 Cholesterol, total;LDL cholesterol; CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg01429635 chr16:4357936 NA -0.53 -6.29 -0.33 1.01e-9 Diisocyanate-induced asthma; CRC trans rs2228479 0.867 rs76885005 chr16:89966668 A/G cg21302420 chr1:112162376 RAP1A 0.66 6.31 0.33 8.91e-10 Skin colour saturation; CRC cis rs10782582 0.532 rs12132503 chr1:76137762 C/G cg03433033 chr1:76189801 ACADM -0.42 -6.13 -0.32 2.53e-9 Daytime sleep phenotypes; CRC cis rs10924970 0.967 rs1933251 chr1:235451172 G/T cg26050004 chr1:235667680 B3GALNT2 0.39 5.77 0.3 1.87e-8 Asthma; CRC cis rs9287719 0.967 rs4669596 chr2:10720572 C/T cg00105475 chr2:10696890 NA 0.45 7.31 0.37 2.1e-12 Prostate cancer; CRC cis rs7412746 0.658 rs8444 chr1:150938571 G/A cg17724175 chr1:150552817 MCL1 0.47 7.07 0.36 9.3e-12 Melanoma; CRC cis rs9549367 0.789 rs9577218 chr13:113894911 A/G cg18105134 chr13:113819100 PROZ -0.74 -11.37 -0.53 1.69e-25 Platelet distribution width; CRC cis rs11587400 0.634 rs4839385 chr1:115121461 A/G cg12756093 chr1:115239321 AMPD1 0.43 5.85 0.31 1.18e-8 Autism; CRC cis rs7191700 0.644 rs12149160 chr16:11439303 G/T cg00044050 chr16:11439710 C16orf75 -0.59 -8.82 -0.44 6.91e-17 Multiple sclerosis; CRC cis rs9902453 1.000 rs9891871 chr17:28370191 C/T cg26525008 chr17:28256777 EFCAB5;SSH2 -0.58 -8.7 -0.43 1.59e-16 Coffee consumption (cups per day); CRC cis rs9467711 0.591 rs6913795 chr6:25848025 T/C cg16898833 chr6:26189333 HIST1H4D 0.79 6.5 0.34 2.95e-10 Autism spectrum disorder or schizophrenia; CRC cis rs514406 0.929 rs12145105 chr1:53340564 T/C cg08859206 chr1:53392774 SCP2 -0.46 -7.03 -0.36 1.17e-11 Monocyte count; CRC cis rs2108622 0.727 rs62107770 chr19:15985425 A/G cg13772218 chr19:15982569 NA 0.48 6.84 0.35 3.96e-11 Circulating phylloquinone levels;Vitamin E levels;Acenocoumarol maintenance dosage;Response to Vitamin E supplementation;Metabolite levels;Warfarin maintenance dose; CRC cis rs17376456 0.825 rs10058331 chr5:93279115 T/G cg09848695 chr5:92956644 FAM172A;MIR2277 0.7 5.99 0.31 5.39e-9 Diabetic retinopathy; CRC cis rs7408868 0.563 rs11085949 chr19:15296917 G/T cg14696996 chr19:15285081 NOTCH3 0.74 7.69 0.39 1.73e-13 Pulse pressure; CRC cis rs9435341 0.965 rs55909997 chr1:107581039 G/A cg15468180 chr1:107600409 PRMT6 0.43 6.42 0.33 4.68e-10 Facial morphology (factor 21, depth of nasal alae); CRC cis rs7662987 0.517 rs2602881 chr4:100040695 A/G cg12011299 chr4:100065546 ADH4 0.49 9.26 0.45 2.63e-18 Smoking initiation; CRC cis rs12451471 0.637 rs7567 chr17:78093549 G/T cg20811857 chr17:78079795 GAA -0.44 -6.3 -0.33 9.63e-10 Plateletcrit;Mean corpuscular hemoglobin concentration; CRC cis rs2032447 0.530 rs9356996 chr6:26008487 C/A cg17691542 chr6:26056736 HIST1H1C 0.48 7.28 0.37 2.45e-12 Intelligence (multi-trait analysis); CRC cis rs13256369 0.708 rs10903310 chr8:8589687 A/C cg06671706 chr8:8559999 CLDN23 -0.56 -8.25 -0.41 3.76e-15 Obesity-related traits; CRC cis rs6968419 0.747 rs3757730 chr7:115882323 G/A cg02561103 chr7:115862891 TES -0.42 -6.35 -0.33 7.09e-10 Intraocular pressure; CRC cis rs11585357 0.557 rs17378462 chr1:17595702 C/T cg08277548 chr1:17600880 PADI3 -0.61 -7.6 -0.39 3.07e-13 Hair shape; CRC cis rs11098499 0.863 rs11098532 chr4:120490726 C/A cg24375607 chr4:120327624 NA 0.49 7.24 0.37 3.1e-12 Corneal astigmatism; CRC cis rs910316 1.000 rs1043674 chr14:75549370 T/C cg11812906 chr14:75593930 NEK9 0.64 10.38 0.5 5.13e-22 Height; CRC cis rs4819052 0.851 rs2236444 chr21:46678226 T/C cg19498844 chr21:46707878 POFUT2;LOC642852 0.79 11.3 0.53 3.18e-25 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs13217239 0.621 rs12527231 chr6:27001288 G/A cg12292205 chr6:26970375 C6orf41 0.56 9.45 0.46 6.32e-19 Schizophrenia; CRC cis rs2836974 0.605 rs2836971 chr21:40652040 A/C cg17971929 chr21:40555470 PSMG1 -0.72 -11.15 -0.52 1.05e-24 Cognitive function; CRC cis rs9467160 0.520 rs2753910 chr6:24442473 C/T cg20631270 chr6:24437470 GPLD1 -0.58 -10.01 -0.48 9.02e-21 Liver enzyme levels; CRC cis rs35146811 0.883 rs4134903 chr7:99711040 G/A cg13334819 chr7:99746414 C7orf59 -0.57 -7.75 -0.39 1.18e-13 Coronary artery disease; CRC cis rs7618915 0.501 rs35526119 chr3:52749334 C/T cg15147215 chr3:52552868 STAB1 -0.63 -10.57 -0.5 1.14e-22 Bipolar disorder; CRC cis rs6681460 1.000 rs9662962 chr1:67121364 C/T cg02459107 chr1:67143332 SGIP1 0.48 8.38 0.42 1.54e-15 Presence of antiphospholipid antibodies; CRC cis rs10504229 0.683 rs55714371 chr8:58131846 T/G cg21724239 chr8:58056113 NA 0.49 6.81 0.35 4.75e-11 Developmental language disorder (linguistic errors); CRC cis rs4237845 0.537 rs11172369 chr12:58280592 T/C cg00677455 chr12:58241039 CTDSP2 0.81 11.17 0.52 9.08e-25 Intelligence (multi-trait analysis); CRC cis rs910316 0.967 rs11159121 chr14:75666029 A/T cg03030879 chr14:75389066 RPS6KL1 0.4 6.18 0.32 1.9e-9 Height; CRC cis rs9549367 0.713 rs4907598 chr13:113861385 C/T cg00898013 chr13:113819073 PROZ 0.5 7.33 0.37 1.77e-12 Platelet distribution width; CRC cis rs1801251 0.644 rs283473 chr2:233654847 A/G cg25237894 chr2:233734115 C2orf82 0.43 6.92 0.36 2.4e-11 Coronary artery disease; CRC cis rs67478160 0.643 rs6576005 chr14:104292369 C/T cg08213375 chr14:104286397 PPP1R13B 0.57 11.68 0.54 1.31e-26 Schizophrenia; CRC cis rs6951245 1.000 rs77702926 chr7:1088838 G/A cg22907277 chr7:1156413 C7orf50 0.71 7.23 0.37 3.34e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs58804349 0.605 rs117540287 chr10:43512040 G/T cg08461752 chr10:43522343 NA -0.82 -7.57 -0.38 3.91e-13 Pediatric bone mineral content (radius); CRC cis rs17331151 0.573 rs76029595 chr3:52868523 C/T cg06204229 chr3:52865917 ITIH4 0.58 7.91 0.4 3.9e-14 Immune reponse to smallpox (secreted IL-2); CRC cis rs34779708 0.931 rs2148482 chr10:35348910 A/G cg03585969 chr10:35415529 CREM 0.59 7.88 0.4 4.94e-14 Inflammatory bowel disease;Crohn's disease; CRC cis rs56235845 0.964 rs4075958 chr5:176784512 A/G cg17261708 chr5:176794207 RGS14 -0.6 -8.9 -0.44 3.71e-17 Hemoglobin concentration;Hematocrit; CRC cis rs7799006 0.722 rs33981648 chr7:2288669 T/C cg08027265 chr7:2291960 NA -0.48 -7.77 -0.39 1.04e-13 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs1865760 0.566 rs9379825 chr6:26083871 C/A cg16482183 chr6:26056742 HIST1H1C 0.52 7.5 0.38 6.17e-13 Height; CRC cis rs6502050 0.871 rs7226049 chr17:80071049 A/G cg19223190 chr17:80058835 NA -0.44 -6.96 -0.36 1.9e-11 Life satisfaction; CRC cis rs11758351 1.000 rs111596617 chr6:26191678 A/T cg01420254 chr6:26195488 NA 0.83 8.68 0.43 1.82e-16 Gout;Renal underexcretion gout; CRC cis rs12048904 1.000 rs12048904 chr1:101331536 C/T cg00063077 chr1:101360652 SLC30A7;EXTL2 -0.51 -7.39 -0.38 1.22e-12 Multiple sclerosis; CRC cis rs9649213 0.593 rs13246868 chr7:97986453 T/C cg24562669 chr7:97807699 LMTK2 0.44 7.32 0.37 1.97e-12 Prostate cancer (SNP x SNP interaction); CRC trans rs2797160 1.000 rs1935772 chr6:125994708 T/C cg05039488 chr6:79577232 IRAK1BP1 -0.49 -7.38 -0.38 1.32e-12 Endometrial cancer; CRC cis rs9287719 0.967 rs2010073 chr2:10736478 C/T cg00105475 chr2:10696890 NA 0.45 7.3 0.37 2.19e-12 Prostate cancer; CRC cis rs5753618 0.583 rs5753632 chr22:31863097 C/T cg02404636 chr22:31891804 SFI1 0.43 5.81 0.31 1.46e-8 Colorectal cancer; CRC cis rs798554 0.567 rs1182191 chr7:2869364 A/T cg19717773 chr7:2847554 GNA12 -0.4 -6.7 -0.35 8.89e-11 Height; CRC cis rs672059 1.000 rs522372 chr1:183157449 C/G ch.1.3577855R chr1:183094577 LAMC1 -0.5 -7.28 -0.37 2.41e-12 Hypertriglyceridemia; CRC cis rs9611565 0.659 rs28530678 chr22:41934961 G/C cg03806693 chr22:41940476 POLR3H -1.11 -13.96 -0.61 4.06e-35 Vitiligo; CRC cis rs3741151 1.000 rs79794992 chr11:73049352 A/G cg17517138 chr11:73019481 ARHGEF17 1.1 9.36 0.46 1.31e-18 GIP levels in response to oral glucose tolerance test (120 minutes); CRC cis rs4654899 1.000 rs7525438 chr1:21458217 G/A cg02927042 chr1:21476669 EIF4G3 -0.47 -7.58 -0.39 3.67e-13 Superior frontal gyrus grey matter volume; CRC trans rs1814175 0.616 rs1794139 chr11:49910855 C/T cg11707556 chr5:10655725 ANKRD33B -0.52 -9.89 -0.48 2.27e-20 Height; CRC cis rs2075371 1.000 rs2241336 chr7:133979578 A/G cg11752832 chr7:134001865 SLC35B4 0.49 7.58 0.39 3.5e-13 Mean platelet volume; CRC cis rs9326248 0.520 rs74830 chr11:117090558 C/T cg10398005 chr11:117014888 PAFAH1B2 0.42 6.17 0.32 1.97e-9 Blood protein levels; CRC cis rs2050392 0.767 rs1536833 chr10:30699265 C/T cg25182066 chr10:30743637 MAP3K8 0.47 6.34 0.33 7.4e-10 Inflammatory bowel disease; CRC cis rs636291 0.510 rs1307487 chr1:10506667 G/A cg17425144 chr1:10567563 PEX14 0.45 9.75 0.47 6.87e-20 Prostate cancer; CRC trans rs11098499 0.863 rs10018280 chr4:120478139 T/G cg25214090 chr10:38739885 LOC399744 0.67 10.5 0.5 1.99e-22 Corneal astigmatism; CRC cis rs11681884 0.710 rs928940 chr2:113877495 G/T cg09040174 chr2:113837401 NA 0.52 5.64 0.3 3.63e-8 Stroke; CRC cis rs1018836 0.773 rs7837109 chr8:91639178 C/T cg16814680 chr8:91681699 NA -0.79 -12.48 -0.57 1.54e-29 Ejection fraction in Tripanosoma cruzi seropositivity; CRC cis rs6831352 0.918 rs29001224 chr4:100047373 G/A cg13256891 chr4:100009986 ADH5 -0.66 -8.89 -0.44 4.04e-17 Alcohol dependence; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg02970861 chr11:62359288 TUT1 0.42 6.0 0.31 5.21e-9 Intelligence (multi-trait analysis); CRC cis rs17711722 0.585 rs6942660 chr7:65302406 C/T cg00343986 chr7:65444356 GUSB 0.55 8.4 0.42 1.32e-15 Calcium levels; CRC trans rs1656966 1.000 rs1656966 chr3:186466252 C/T cg01638175 chr3:49171179 LAMB2 0.4 6.53 0.34 2.54e-10 Myopia (pathological); CRC cis rs7829975 0.667 rs1877119 chr8:8707197 C/G cg06636001 chr8:8085503 FLJ10661 0.56 8.38 0.42 1.54e-15 Mood instability; CRC cis rs9381040 0.655 rs2268188 chr6:41042590 T/G cg09580153 chr6:41068724 NFYA;LOC221442 -0.41 -5.87 -0.31 1.06e-8 Alzheimer's disease (late onset); CRC cis rs9341808 0.754 rs1324121 chr6:80946077 A/G cg08355045 chr6:80787529 NA 0.42 6.71 0.35 8.63e-11 Sitting height ratio; CRC cis rs6502050 0.871 rs62079998 chr17:80077245 A/C cg22110888 chr17:80059540 CCDC57 -0.43 -6.69 -0.35 9.49e-11 Life satisfaction; CRC cis rs3741404 0.560 rs2875748 chr11:63915537 G/A cg20160996 chr11:63990575 FERMT3 0.41 6.57 0.34 2.02e-10 Platelet count; CRC cis rs9902453 0.808 rs12452288 chr17:28235220 A/G cg26525008 chr17:28256777 EFCAB5;SSH2 0.57 8.56 0.43 4.53e-16 Coffee consumption (cups per day); CRC cis rs3862030 0.694 rs1984795 chr10:104226830 C/T cg11453585 chr10:104263688 ACTR1A;SUFU -0.77 -13.41 -0.59 5.15e-33 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for body mass index; CRC cis rs910316 0.737 rs175071 chr14:75498177 A/G cg11812906 chr14:75593930 NEK9 -0.55 -8.71 -0.43 1.54e-16 Height; CRC cis rs897984 0.762 rs897986 chr16:30980902 T/C cg00531865 chr16:30841666 NA 0.47 6.78 0.35 5.6e-11 Dementia with Lewy bodies; CRC cis rs6570726 0.935 rs110289 chr6:145865176 C/G cg05347473 chr6:146136440 FBXO30 0.38 5.97 0.31 6.12e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs3764400 0.508 rs978263 chr17:46180664 A/G cg10706073 chr17:46328419 SKAP1 0.61 6.62 0.34 1.44e-10 Body mass index; CRC cis rs7528419 1.000 rs629301 chr1:109818306 G/T cg00908766 chr1:109817496 CELSR2 0.44 8.07 0.41 1.3e-14 Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease);Myocardial infarction;Lipoprotein-associated phospholipase A2 activity and mass;Lipoprotein-associated phospholipase A2 activity change in response to darapladib treatment in cardiovascular disease;Cholesterol, total;Coronary artery disease; CRC cis rs7827545 1.000 rs7827545 chr8:135566567 C/T cg17885191 chr8:135476712 NA 0.52 7.17 0.37 5.13e-12 Hypertension (SNP x SNP interaction); CRC cis rs7223966 1.000 rs8064261 chr17:61705212 G/A cg23090583 chr17:61904693 PSMC5;FTSJ3 0.49 6.26 0.33 1.19e-9 Hip circumference adjusted for BMI;Body mass index; CRC cis rs8180040 0.903 rs7636423 chr3:47309134 C/G cg27129171 chr3:47204927 SETD2 0.7 11.58 0.54 2.96e-26 Colorectal cancer; CRC cis rs2777491 0.915 rs28583065 chr15:41608470 T/C cg18705301 chr15:41695430 NDUFAF1 -0.7 -11.6 -0.54 2.55e-26 Ulcerative colitis; CRC cis rs992157 0.798 rs1017698 chr2:219170525 A/G cg04880052 chr2:219191631 PNKD -0.4 -6.6 -0.34 1.64e-10 Colorectal cancer; CRC cis rs7772486 0.754 rs6915718 chr6:146100676 A/G cg13319975 chr6:146136371 FBXO30 0.45 6.5 0.34 3.01e-10 Lobe attachment (rater-scored or self-reported); CRC cis rs7827545 1.000 rs4909909 chr8:135564627 T/C cg07299736 chr8:135490787 ZFAT -0.37 -6.2 -0.32 1.73e-9 Hypertension (SNP x SNP interaction); CRC cis rs6460942 0.630 rs62448731 chr7:12341174 G/A cg06484146 chr7:12443880 VWDE -0.61 -6.56 -0.34 2.05e-10 Coronary artery disease; CRC cis rs9325144 0.560 rs1825802 chr12:38650341 C/T cg26384229 chr12:38710491 ALG10B -0.49 -7.34 -0.38 1.71e-12 Morning vs. evening chronotype; CRC cis rs2836974 0.897 rs3945 chr21:40566067 A/G cg11890956 chr21:40555474 PSMG1 1.01 16.12 0.66 1.76e-43 Cognitive function; CRC cis rs10894147 0.756 rs1783916 chr11:129757099 G/A cg27255275 chr11:129766154 NFRKB 0.41 5.72 0.3 2.44e-8 Obesity-related traits; CRC cis rs1552244 0.882 rs9312044 chr3:10037481 T/C cg08888203 chr3:10149979 C3orf24 0.6 8.47 0.42 8.55e-16 Alzheimer's disease; CRC cis rs13256369 0.865 rs13282523 chr8:8577293 C/G cg18904891 chr8:8559673 CLDN23 0.48 6.63 0.34 1.4e-10 Obesity-related traits; CRC cis rs7044106 0.537 rs10818474 chr9:123489964 C/T cg09586646 chr9:123605570 PSMD5;LOC253039 0.71 9.85 0.48 3.09e-20 Hip circumference adjusted for BMI; CRC cis rs13108904 0.901 rs6851528 chr4:1296009 G/A cg15763984 chr4:1342303 KIAA1530 0.34 5.76 0.3 1.89e-8 Obesity-related traits; CRC cis rs12612619 0.704 rs6714547 chr2:27321206 T/G cg00617064 chr2:27272375 NA -0.36 -5.84 -0.31 1.27e-8 Venous thromboembolism adjusted for sickle cell variant rs77121243-T; CRC cis rs1448094 0.512 rs4362214 chr12:86245145 C/T cg18827107 chr12:86230957 RASSF9 -0.45 -7.42 -0.38 9.97e-13 Major depressive disorder; CRC cis rs7662987 0.517 rs2851286 chr4:100014976 A/G cg13256891 chr4:100009986 ADH5 -0.64 -8.7 -0.43 1.64e-16 Smoking initiation; CRC cis rs2404602 0.647 rs11072610 chr15:76930805 C/A cg23625390 chr15:77176239 SCAPER -0.89 -13.87 -0.61 8.84e-35 Blood metabolite levels; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg16740543 chr6:170123723 PHF10 0.44 6.44 0.33 4.21e-10 Intelligence (multi-trait analysis); CRC cis rs780094 0.564 rs4665978 chr2:27648726 T/C cg17158414 chr2:27665306 KRTCAP3 -0.27 -5.84 -0.31 1.27e-8 Calcium levels;Fasting blood insulin;Metabolic traits;Triglyceride levels;Fasting plasma glucose;Urate levels in overweight individuals;Urate levels in obese individuals;Uric acid levels;Height;Age-related diseases, mortality and associated endophenotypes;Renal underexcretion gout;Fasting blood glucose (BMI interaction);Urate levels;Gondoic acid (20:1n-9) levels;Fasting blood insulin (BMI interaction);Triglycerides;Plasma omega-3 polyunsaturated fatty acid levels (docosapentaenoic acid);Type 2 diabetes;Nonalcoholic fatty liver disease;Hypertriglyceridemia;C-reactive protein;Age-related disease endophenotypes;LDL cholesterol;Metabolic syndrome;Crohn's disease;Alcohol consumption (drinks per week);Homeostasis model assessment of insulin resistance;Alcohol consumption;Red blood cell count;Fasting blood glucose; CRC cis rs992157 0.560 rs4674274 chr2:219089131 A/T cg00012203 chr2:219082015 ARPC2 -0.54 -8.52 -0.43 5.83e-16 Colorectal cancer; CRC cis rs7647973 0.925 rs4955423 chr3:49220448 G/A cg20833759 chr3:49053208 WDR6;DALRD3 0.55 8.49 0.42 7.08e-16 Menarche (age at onset); CRC cis rs7618915 0.571 rs1961958 chr3:52585990 A/G cg18099408 chr3:52552593 STAB1 -0.45 -7.43 -0.38 9.15e-13 Bipolar disorder; CRC cis rs12135062 0.851 rs2651927 chr1:3101762 A/C cg25382214 chr1:3105252 PRDM16 -0.43 -7.1 -0.36 7.66e-12 Migraine; CRC cis rs9322193 0.962 rs4869731 chr6:150131208 T/C cg07701084 chr6:150067640 NUP43 0.48 6.7 0.35 8.9e-11 Lung cancer; CRC cis rs9522267 0.535 rs11069900 chr13:112233285 G/A cg10483660 chr13:112241077 NA -0.48 -9.05 -0.45 1.27e-17 Hepatitis; CRC cis rs910316 1.000 rs175492 chr14:75545220 A/C cg11812906 chr14:75593930 NEK9 0.6 9.72 0.47 8.33e-20 Height; CRC cis rs174479 0.677 rs174456 chr11:61656182 G/T cg01500311 chr11:61656094 FADS3 0.35 5.65 0.3 3.55e-8 Sphingolipid levels; CRC cis rs897984 0.683 rs8046001 chr16:30833321 C/T cg02466173 chr16:30829666 NA -0.87 -16.19 -0.67 8.67e-44 Dementia with Lewy bodies; CRC cis rs8072100 0.840 rs1912482 chr17:45454883 G/A cg08085267 chr17:45401833 C17orf57 -0.68 -11.3 -0.53 3.19e-25 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs597539 0.652 rs602805 chr11:68662076 A/T cg06112835 chr11:68658793 MRPL21 0.47 7.64 0.39 2.35e-13 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg10493356 chr22:31608270 LIMK2 0.49 6.96 0.36 1.85e-11 Anxiety disorder; CRC cis rs12586317 0.547 rs2383693 chr14:35500205 A/C cg05294307 chr14:35346193 BAZ1A -0.69 -7.45 -0.38 8.53e-13 Psoriasis; CRC cis rs7212590 0.748 rs59685433 chr17:57891207 T/C cg10252138 chr17:58120427 NA -0.54 -5.64 -0.3 3.73e-8 Granulocyte percentage of myeloid white cells;Monocyte count;Monocyte percentage of white cells; CRC cis rs801193 1.000 rs1553610 chr7:66197233 T/C cg11764359 chr7:65958608 NA 0.54 8.26 0.41 3.49e-15 Aortic root size; CRC cis rs4237845 0.735 rs11172375 chr12:58291574 G/C cg02175503 chr12:58329896 NA 0.52 6.81 0.35 4.54e-11 Intelligence (multi-trait analysis); CRC cis rs4689592 0.513 rs3857177 chr4:7066332 G/A cg19539972 chr4:7069911 GRPEL1 0.75 9.66 0.47 1.37e-19 Monocyte percentage of white cells; CRC trans rs875971 0.545 rs3936065 chr7:65790564 C/T cg02869306 chr7:64672164 INTS4L1 -0.44 -6.47 -0.34 3.54e-10 Aortic root size; CRC cis rs11971779 0.666 rs7786851 chr7:139007020 C/G cg07862535 chr7:139043722 LUC7L2 -0.68 -7.96 -0.4 2.87e-14 Diisocyanate-induced asthma; CRC cis rs7666738 0.791 rs28579101 chr4:98843203 T/C cg17366294 chr4:99064904 C4orf37 0.41 6.57 0.34 1.92e-10 Colonoscopy-negative controls vs population controls; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg07560534 chr9:100745354 ANP32B 0.49 6.71 0.35 8.52e-11 Response to antipsychotic treatment; CRC cis rs6570726 0.791 rs385729 chr6:145855465 T/C cg23711669 chr6:146136114 FBXO30 0.75 13.11 0.59 7.31e-32 Lobe attachment (rater-scored or self-reported); CRC cis rs2836974 0.627 rs8127986 chr21:40687211 A/T cg11644478 chr21:40555479 PSMG1 -0.65 -10.22 -0.49 1.74e-21 Cognitive function; CRC cis rs9911578 0.935 rs302873 chr17:56769481 C/G cg05425664 chr17:57184151 TRIM37 -0.51 -8.01 -0.4 2.01e-14 Intelligence (multi-trait analysis); CRC cis rs1799949 0.965 rs8176322 chr17:41195773 A/G cg01879757 chr17:41196368 BRCA1 -0.41 -6.21 -0.32 1.63e-9 Menopause (age at onset); CRC cis rs514406 0.698 rs576891 chr1:53364976 A/G cg27535305 chr1:53392650 SCP2 -0.44 -7.68 -0.39 1.83e-13 Monocyte count; CRC cis rs6088580 0.634 rs6059897 chr20:33113224 A/G cg08999081 chr20:33150536 PIGU 0.65 11.92 0.55 1.82e-27 Glomerular filtration rate (creatinine); CRC cis rs4332037 0.624 rs73046339 chr7:1889300 G/A cg25834613 chr7:1915315 MAD1L1 -0.4 -6.18 -0.32 1.84e-9 Bipolar disorder; CRC cis rs8141529 0.732 rs6005881 chr22:29183133 A/G cg02153584 chr22:29168773 CCDC117 0.52 7.74 0.39 1.23e-13 Lymphocyte counts; CRC cis rs597539 0.652 rs513359 chr11:68669496 A/T cg04772025 chr11:68637568 NA -0.48 -7.41 -0.38 1.06e-12 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs2717559 0.542 rs10956986 chr8:143886601 C/T cg20041105 chr8:143859282 LYNX1 -0.7 -13.22 -0.59 2.61e-32 Urinary tract infection frequency; CRC cis rs4555082 0.957 rs2816627 chr14:105736109 A/G cg13114125 chr14:105738426 BRF1 -0.74 -11.23 -0.53 5.62e-25 Mean platelet volume;Platelet distribution width; CRC cis rs4478858 0.735 rs7556340 chr1:31788453 A/T cg00250761 chr1:31883323 NA -0.43 -8.35 -0.42 1.97e-15 Alcohol dependence; CRC cis rs3026445 0.778 rs7976889 chr12:110857694 A/G cg12870014 chr12:110450643 ANKRD13A 0.37 5.7 0.3 2.73e-8 QT interval; CRC cis rs10927875 0.691 rs1048302 chr1:16340879 T/G cg24140574 chr1:16342155 HSPB7 0.42 5.61 0.3 4.31e-8 Dilated cardiomyopathy; CRC cis rs2832191 0.791 rs7282843 chr21:30475226 A/G cg08807101 chr21:30365312 RNF160 0.64 10.28 0.49 1.11e-21 Dental caries; CRC cis rs853679 0.760 rs11967137 chr6:28199764 A/G cg15845792 chr6:28175446 NA 0.76 7.99 0.4 2.34e-14 Depression; CRC cis rs9487051 0.702 rs368467 chr6:109519451 T/C cg21918786 chr6:109611834 NA -0.35 -6.05 -0.32 3.9e-9 Reticulocyte fraction of red cells; CRC cis rs853679 0.517 rs9380061 chr6:28132803 T/C cg25164649 chr6:28176230 NA 0.78 9.66 0.47 1.33e-19 Depression; CRC cis rs1799949 0.930 rs4584865 chr17:41424919 C/G cg25072359 chr17:41440525 NA 0.45 6.7 0.35 8.96e-11 Menopause (age at onset); CRC cis rs3858526 0.834 rs10839169 chr11:6003190 C/G cg13902645 chr11:5959945 NA -0.53 -6.71 -0.35 8.66e-11 DNA methylation (variation); CRC cis rs9611565 0.659 rs9611610 chr22:41949259 A/G cg06634786 chr22:41940651 POLR3H -0.73 -8.39 -0.42 1.42e-15 Vitiligo; CRC cis rs1018836 0.818 rs2285232 chr8:91546162 C/G cg16814680 chr8:91681699 NA -0.6 -9.24 -0.45 3.14e-18 Ejection fraction in Tripanosoma cruzi seropositivity; CRC cis rs9291683 0.509 rs10939671 chr4:10050815 T/C cg02734326 chr4:10020555 SLC2A9 0.36 5.73 0.3 2.32e-8 Bone mineral density; CRC cis rs4689592 0.513 rs4689586 chr4:7067413 A/G cg26116260 chr4:7069785 GRPEL1 0.98 14.93 0.64 7.78e-39 Monocyte percentage of white cells; CRC cis rs1348850 0.914 rs12612857 chr2:178467144 A/G cg22681709 chr2:178499509 PDE11A -0.38 -6.77 -0.35 5.84e-11 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs853679 0.542 rs9380063 chr6:28137853 A/G cg02683197 chr6:28174875 NA 0.87 10.73 0.51 3.25e-23 Depression; CRC cis rs2120019 0.567 rs8029351 chr15:75177237 A/C cg17294928 chr15:75287854 SCAMP5 -0.6 -6.99 -0.36 1.5e-11 Blood trace element (Zn levels); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg27367093 chr11:72145746 CLPB 0.47 7.69 0.39 1.77e-13 Liver disease severity in Alagille syndrome; CRC cis rs8072100 0.935 rs8070759 chr17:45638760 C/T cg08085267 chr17:45401833 C17orf57 0.63 10.09 0.49 4.8e-21 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs6681460 1.000 rs2031478 chr1:67123742 C/A cg02459107 chr1:67143332 SGIP1 0.48 8.33 0.42 2.27e-15 Presence of antiphospholipid antibodies; CRC cis rs16867321 0.950 rs1919148 chr2:181501758 G/A cg23363182 chr2:181467187 NA -0.51 -6.65 -0.34 1.21e-10 Obesity; CRC trans rs1455244 0.700 rs7229302 chr18:11508904 G/T cg22331074 chr8:42751762 RNF170;HOOK3 0.41 6.45 0.34 3.88e-10 Schizophrenia; CRC cis rs9487051 0.676 rs9398196 chr6:109601554 A/G cg12927641 chr6:109611667 NA -0.37 -6.4 -0.33 5.2400000000000005e-10 Reticulocyte fraction of red cells; CRC cis rs9814567 0.806 rs9857995 chr3:134316706 C/G cg06541857 chr3:134203789 ANAPC13;CEP63 0.36 5.61 0.3 4.22e-8 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC trans rs7618501 0.633 rs6446193 chr3:50059758 T/C cg21659725 chr3:3221576 CRBN -0.54 -8.57 -0.43 3.96e-16 Intelligence (multi-trait analysis); CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg11339840 chr1:203596058 ATP2B4 0.47 6.14 0.32 2.32e-9 Thyroid stimulating hormone; CRC trans rs17641971 0.965 rs341815 chr8:49978424 A/C cg18784943 chr17:79371681 NA -0.41 -6.22 -0.32 1.54e-9 Blood metabolite levels; CRC cis rs7937682 0.883 rs12804962 chr11:111442683 A/T cg09085632 chr11:111637200 PPP2R1B 0.89 15.68 0.65 8.9e-42 Primary sclerosing cholangitis; CRC cis rs10504229 0.683 rs55714371 chr8:58131846 T/G cg02725872 chr8:58115012 NA -0.64 -11.55 -0.54 3.85e-26 Developmental language disorder (linguistic errors); CRC cis rs2991971 0.967 rs6661321 chr1:45954599 C/G cg03123370 chr1:45965343 CCDC163P;MMACHC -0.39 -5.9 -0.31 8.9e-9 High light scatter reticulocyte count; CRC trans rs1814175 0.645 rs1963215 chr11:49931486 G/A cg15704280 chr7:45808275 SEPT13 -0.95 -16.82 -0.68 3.11e-46 Height; CRC cis rs6502050 0.835 rs10163482 chr17:80110394 C/A cg22110888 chr17:80059540 CCDC57 0.4 6.44 0.33 4.17e-10 Life satisfaction; CRC trans rs1814175 0.645 rs866427 chr11:49923853 G/A cg15704280 chr7:45808275 SEPT13 -0.95 -16.82 -0.68 3.11e-46 Height; CRC cis rs10504229 0.683 rs7827014 chr8:58132230 G/A cg02290350 chr8:58132656 NA -0.58 -8.16 -0.41 7.29e-15 Developmental language disorder (linguistic errors); CRC cis rs7680126 0.633 rs4698023 chr4:10304726 A/G cg11266682 chr4:10021025 SLC2A9 -0.37 -5.97 -0.31 6.27e-9 Urate levels in lean individuals;Urate levels in overweight individuals;Urate levels in obese individuals; CRC cis rs6502050 0.805 rs4789720 chr17:80157490 G/C cg13198984 chr17:80129470 CCDC57 0.45 8.01 0.4 1.99e-14 Life satisfaction; CRC cis rs7572733 0.565 rs11891750 chr2:198434319 G/A cg10820045 chr2:198174542 NA 0.34 5.99 0.31 5.42e-9 Dermatomyositis; CRC cis rs73058052 0.867 rs57940349 chr19:50097607 C/T cg09250473 chr19:50168907 IRF3;BCL2L12 0.5 5.79 0.3 1.6e-8 Fibrinogen levels; CRC cis rs4819052 0.851 rs28622522 chr21:46676599 G/T cg11663144 chr21:46675770 NA -0.85 -14.74 -0.63 4.03e-38 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs9291683 0.595 rs10939665 chr4:10037628 T/C cg00071950 chr4:10020882 SLC2A9 0.67 12.66 0.57 3.38e-30 Bone mineral density; CRC cis rs6502050 0.805 rs8082653 chr17:80162382 G/A cg13198984 chr17:80129470 CCDC57 0.47 8.45 0.42 9.43e-16 Life satisfaction; CRC cis rs9346649 0.630 rs6913441 chr6:168491271 C/T cg02770688 chr6:168491649 NA 0.59 8.68 0.43 1.86e-16 Venous thromboembolism adjusted for sickle cell variant rs77121243-T; CRC cis rs6694672 1.000 rs10922169 chr1:197101105 T/C cg13682187 chr1:196946512 CFHR5 0.47 7.53 0.38 4.89e-13 Asthma; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg22708233 chr11:47198576 ARFGAP2 -0.37 -6.01 -0.31 5.01e-9 Myopia (pathological); CRC cis rs1552244 0.872 rs6771931 chr3:10113408 C/G cg10729496 chr3:10149963 C3orf24 0.5 6.74 0.35 7.23e-11 Alzheimer's disease; CRC cis rs4665630 0.522 rs114880940 chr2:23930352 G/A cg07265300 chr2:24346000 PFN4;LOC375190 0.79 5.78 0.3 1.69e-8 Hypertension; CRC cis rs977987 0.806 rs4993969 chr16:75411521 A/T cg03315344 chr16:75512273 CHST6 0.53 8.97 0.44 2.24e-17 Dupuytren's disease; CRC cis rs4920343 0.737 rs4920530 chr1:19095101 A/C cg19637330 chr1:19110922 NA -0.4 -6.02 -0.31 4.67e-9 Knee osteoarthritis; CRC cis rs9549260 0.753 rs9532578 chr13:41236407 G/A cg21288729 chr13:41239152 FOXO1 0.48 5.96 0.31 6.37e-9 Red blood cell count; CRC cis rs9611565 0.694 rs106860 chr22:41840407 C/T cg03806693 chr22:41940476 POLR3H -1.09 -13.46 -0.6 3.38e-33 Vitiligo; CRC cis rs4290604 1.000 rs4290604 chr2:238070885 A/G cg23555395 chr2:238036564 NA -0.5 -5.96 -0.31 6.6e-9 Asthma; CRC cis rs1023500 0.573 rs133374 chr22:42465941 G/A cg11915388 chr22:42470451 FAM109B -0.42 -6.47 -0.34 3.63e-10 Schizophrenia; CRC trans rs2303319 0.504 rs72870226 chr2:162420429 T/C cg27113153 chr11:123612418 ZNF202 -0.72 -6.15 -0.32 2.25e-9 Cognitive function; CRC cis rs6831352 0.918 rs2851249 chr4:100044822 T/C cg13256891 chr4:100009986 ADH5 0.65 8.85 0.44 5.36e-17 Alcohol dependence; CRC trans rs11098499 0.954 rs7437420 chr4:120312903 A/G cg25214090 chr10:38739885 LOC399744 0.63 9.79 0.47 4.8e-20 Corneal astigmatism; CRC cis rs6762 0.642 rs28692469 chr11:839675 T/C cg11173246 chr11:841376 TSPAN4;POLR2L -0.34 -5.68 -0.3 2.97e-8 Mean platelet volume; CRC trans rs1814175 0.650 rs6486000 chr11:49659090 T/A cg03929089 chr4:120376271 NA -0.84 -13.57 -0.6 1.31e-33 Height; CRC cis rs4363385 0.647 rs56412380 chr1:153000705 T/C cg25856811 chr1:152973957 SPRR3 -0.23 -6.04 -0.32 4.23e-9 Inflammatory skin disease; CRC cis rs9648716 0.935 rs1267615 chr7:140513650 T/C cg10747023 chr7:140774559 NA 0.44 5.8 0.3 1.52e-8 Type 2 diabetes; CRC trans rs4689592 0.503 rs66885632 chr4:7053738 T/C cg07817883 chr1:32538562 TMEM39B 0.67 7.37 0.38 1.36e-12 Monocyte percentage of white cells; CRC cis rs8045833 0.714 rs749681 chr16:88570675 A/G cg05152867 chr16:88568237 ZFPM1 0.36 5.98 0.31 5.71e-9 Vascular endothelial growth factor levels; CRC cis rs7216064 1.000 rs8071463 chr17:65938655 C/T cg12091567 chr17:66097778 LOC651250 0.64 8.09 0.41 1.13e-14 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CRC cis rs929354 0.557 rs62491947 chr7:156960813 G/A cg05182265 chr7:156933206 UBE3C -0.77 -14.47 -0.62 4.73e-37 Body mass index; CRC trans rs600806 0.850 rs2303875 chr1:109955010 A/C cg22273042 chr8:81083829 TPD52 -0.45 -6.0 -0.31 5.16e-9 Intelligence (multi-trait analysis); CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg13064914 chr1:26799365 HMGN2 0.44 6.07 0.32 3.62e-9 Anxiety disorder; CRC cis rs4481887 0.741 rs6587467 chr1:248550976 T/G cg26353448 chr1:248524236 OR2T4 -0.31 -5.95 -0.31 6.97e-9 Common traits (Other); CRC cis rs7619833 0.620 rs9842044 chr3:27263248 G/C cg02860705 chr3:27208620 NA 0.37 5.85 0.31 1.16e-8 Breast cancer; CRC cis rs116095464 0.558 rs10057492 chr5:239503 T/C cg22496380 chr5:211416 CCDC127 -0.91 -10.38 -0.5 5.2e-22 Breast cancer; CRC cis rs34172651 0.517 rs8059004 chr16:24837905 G/A cg00339695 chr16:24857497 SLC5A11 0.42 8.55 0.43 4.81e-16 Intelligence (multi-trait analysis); CRC cis rs7666738 0.830 rs62321569 chr4:98984250 T/A cg05340658 chr4:99064831 C4orf37 0.6 9.41 0.46 8.57e-19 Colonoscopy-negative controls vs population controls; CRC cis rs1801251 0.727 rs6437071 chr2:233568793 G/A cg25237894 chr2:233734115 C2orf82 0.42 6.75 0.35 6.51e-11 Coronary artery disease; CRC cis rs7786808 0.707 rs11770299 chr7:158228822 G/A cg09998033 chr7:158218633 PTPRN2 -0.62 -8.92 -0.44 3.35e-17 Obesity-related traits; CRC cis rs4588572 0.644 rs891150 chr5:77761794 G/A cg11547950 chr5:77652471 NA -0.53 -7.71 -0.39 1.49e-13 Triglycerides; CRC trans rs944990 0.595 rs10123378 chr9:96375217 C/T cg19320564 chr1:40157253 HPCAL4 0.37 5.98 0.31 5.93e-9 Body mass index; CRC cis rs6921919 0.583 rs9461458 chr6:28355875 C/T cg21251018 chr6:28226885 NKAPL 0.41 6.24 0.33 1.35e-9 Autism spectrum disorder or schizophrenia; CRC trans rs196889 0.831 rs196890 chr8:24733546 G/C cg08034077 chr17:50236087 CA10 0.44 6.16 0.32 2.11e-9 Seasonality; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg03446863 chr6:41702426 TFEB 0.43 5.97 0.31 6.21e-9 Response to antipsychotic treatment; CRC cis rs344364 0.511 rs2982449 chr16:1947878 C/G cg00046913 chr16:1877150 HAGH;FAHD1 -0.58 -6.06 -0.32 3.66e-9 Glomerular filtration rate in chronic kidney disease; CRC cis rs10927875 0.688 rs2009371 chr1:16348083 A/T cg22431228 chr1:16359049 CLCNKA -0.44 -7.84 -0.4 6.46e-14 Dilated cardiomyopathy; CRC cis rs9527 0.590 rs3781281 chr10:104852648 A/G cg04362960 chr10:104952993 NT5C2 -0.59 -8.12 -0.41 9.65e-15 Arsenic metabolism; CRC cis rs9807989 0.839 rs4988955 chr2:102967928 A/G cg03938978 chr2:103052716 IL18RAP 0.36 5.71 0.3 2.53e-8 Asthma; CRC cis rs10504229 1.000 rs67344620 chr8:58187537 C/A cg01721255 chr8:58191610 C8orf71 0.49 6.17 0.32 2e-9 Developmental language disorder (linguistic errors); CRC cis rs72945132 0.882 rs947812 chr11:70209169 C/T cg14191688 chr11:70257035 CTTN 0.44 5.88 0.31 9.92e-9 Coronary artery disease; CRC cis rs9534288 0.956 rs2094244 chr13:46605803 T/C cg15192986 chr13:46630673 CPB2 -0.72 -10.3 -0.49 9.63e-22 Blood protein levels; CRC cis rs10463316 0.823 rs7700342 chr5:150776323 C/T cg03212797 chr5:150827313 SLC36A1 -0.53 -8.36 -0.42 1.77e-15 Metabolite levels (Pyroglutamine); CRC cis rs9311474 0.502 rs4687624 chr3:52563572 C/T cg08222913 chr3:52553049 STAB1 -0.37 -6.91 -0.36 2.49e-11 Electroencephalogram traits; CRC cis rs7666738 0.830 rs6532723 chr4:99052147 A/T cg17366294 chr4:99064904 C4orf37 0.45 7.75 0.39 1.16e-13 Colonoscopy-negative controls vs population controls; CRC cis rs7258465 0.931 rs271629 chr19:18623198 G/A cg10790698 chr19:18539756 SSBP4 -0.45 -8.72 -0.43 1.37e-16 Breast cancer; CRC cis rs2019137 0.560 rs10206269 chr2:113990393 C/A cg07772999 chr2:113993052 PAX8;LOC440839;LOC654433 0.56 8.26 0.41 3.64e-15 Lymphocyte counts; CRC cis rs801193 1.000 rs2707856 chr7:66211010 A/T cg18876405 chr7:65276391 NA 0.6 10.62 0.51 7.44e-23 Aortic root size; CRC cis rs10883723 0.775 rs2296579 chr10:104241375 A/G cg22532475 chr10:104410764 TRIM8 -0.35 -6.28 -0.33 1.06e-9 Allergic disease (asthma, hay fever or eczema); CRC cis rs7726839 0.540 rs72703080 chr5:595238 A/G cg16447950 chr5:562315 NA -0.72 -9.24 -0.45 3.15e-18 Obesity-related traits; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg26210003 chr14:65290110 SPTB 0.41 6.03 0.32 4.34e-9 Response to antipsychotic treatment; CRC cis rs561341 0.941 rs8066558 chr17:30272879 G/T cg19193384 chr17:30244184 NA -0.53 -6.88 -0.35 3.1e-11 Hip circumference adjusted for BMI; CRC cis rs9291683 0.567 rs12499857 chr4:9995376 G/A cg11266682 chr4:10021025 SLC2A9 0.53 11.26 0.53 4.12e-25 Bone mineral density; CRC cis rs8180040 0.966 rs13064843 chr3:47415467 C/T cg02527881 chr3:46936655 PTH1R -0.39 -7.46 -0.38 7.82e-13 Colorectal cancer; CRC cis rs7412746 0.634 rs3754212 chr1:150738200 A/G cg15448220 chr1:150897856 SETDB1 0.54 7.59 0.39 3.39e-13 Melanoma; CRC cis rs910316 1.000 rs12588240 chr14:75612083 C/A cg11812906 chr14:75593930 NEK9 0.64 10.41 0.5 3.98e-22 Height; CRC cis rs7119 0.651 rs34829483 chr15:77835986 C/T cg27398640 chr15:77910606 LINGO1 -0.41 -6.94 -0.36 2.07e-11 Type 2 diabetes; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg06005396 chr19:590541 HCN2 0.35 6.12 0.32 2.69e-9 Liver disease severity in Alagille syndrome; CRC cis rs921968 0.613 rs2710250 chr2:219543277 A/G cg02176678 chr2:219576539 TTLL4 -0.46 -7.28 -0.37 2.49e-12 Mean corpuscular hemoglobin concentration; CRC cis rs877282 0.898 rs10904546 chr10:757222 A/G cg17470449 chr10:769945 NA 0.64 8.39 0.42 1.42e-15 Uric acid levels; CRC cis rs2836974 0.931 rs12151994 chr21:40690397 A/C cg11890956 chr21:40555474 PSMG1 1.01 16.04 0.66 3.63e-43 Cognitive function; CRC cis rs9467711 0.606 rs9379899 chr6:26603015 T/A cg16898833 chr6:26189333 HIST1H4D 0.94 7.7 0.39 1.64e-13 Autism spectrum disorder or schizophrenia; CRC cis rs798554 0.797 rs1182183 chr7:2873136 C/T cg17321639 chr7:2759063 NA -0.54 -7.24 -0.37 3.16e-12 Height; CRC cis rs7811142 0.943 rs11769886 chr7:99998607 G/A cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.98 12.29 0.56 8.1e-29 Platelet count; CRC cis rs13118159 0.742 rs7679860 chr4:1333987 C/T cg24560729 chr4:1342394 KIAA1530 0.4 7.03 0.36 1.19e-11 Longevity; CRC cis rs45509595 0.841 rs370155 chr6:27782031 T/G cg06470822 chr6:28175283 NA 0.67 5.84 0.31 1.25e-8 Breast cancer; CRC cis rs7927592 0.763 rs11822059 chr11:68300822 T/G cg16797656 chr11:68205561 LRP5 0.48 8.88 0.44 4.43e-17 Total body bone mineral density; CRC cis rs7598759 0.548 rs1823328 chr2:232355184 G/A cg21424120 chr2:232395308 NMUR1 0.28 5.68 0.3 3.03e-8 Noise-induced hearing loss; CRC cis rs9733 0.650 rs2048558 chr1:150571730 A/G cg18016565 chr1:150552671 MCL1 -0.48 -7.1 -0.36 7.67e-12 Tonsillectomy; CRC cis rs12472274 0.646 rs11677736 chr2:239087198 A/T cg17459225 chr2:239074497 NA 0.67 8.41 0.42 1.26e-15 Phospholipid levels (plasma); CRC cis rs10046574 0.831 rs7780345 chr7:135137731 T/C cg27474649 chr7:135195673 CNOT4 0.69 5.71 0.3 2.49e-8 Peripheral arterial disease (traffic-related air pollution interaction); CRC trans rs1712517 0.873 rs1712516 chr10:105033628 G/A cg23009290 chr3:125982568 NA -0.34 -5.98 -0.31 5.73e-9 Migraine; CRC cis rs8060686 1.000 rs8060686 chr16:67911517 T/C cg19582491 chr16:67682965 RLTPR -0.4 -5.67 -0.3 3.2e-8 HDL cholesterol;Metabolic syndrome; CRC cis rs881375 0.967 rs2109896 chr9:123683106 C/T cg09419670 chr9:123605666 PSMD5;LOC253039 0.59 8.77 0.44 9.66e-17 Rheumatoid arthritis; CRC cis rs7705042 0.865 rs2338822 chr5:141503059 T/C cg08523384 chr5:141488047 NDFIP1 -0.33 -5.76 -0.3 1.97e-8 Asthma; CRC cis rs12760731 0.511 rs12758980 chr1:178611633 G/A cg00404053 chr1:178313656 RASAL2 0.6 6.94 0.36 2.05e-11 Obesity-related traits; CRC cis rs9291683 0.692 rs1558489 chr4:10325489 T/A cg00071950 chr4:10020882 SLC2A9 -0.46 -7.57 -0.39 3.78e-13 Bone mineral density; CRC trans rs9929218 1.000 rs35069703 chr16:68789445 G/A cg04657470 chr2:198365150 HSPE1;HSPD1 -0.93 -13.05 -0.58 1.22e-31 Colorectal cancer; CRC cis rs7666738 0.830 rs13133355 chr4:98919415 A/G cg05340658 chr4:99064831 C4orf37 0.57 8.52 0.43 5.83e-16 Colonoscopy-negative controls vs population controls; CRC cis rs2361718 0.900 rs8081698 chr17:78104212 G/A cg24585782 chr17:78113791 EIF4A3 -0.37 -5.71 -0.3 2.56e-8 Yeast infection; CRC trans rs853679 0.546 rs200950 chr6:27835772 A/G cg06606381 chr12:133084897 FBRSL1 -0.77 -6.6 -0.34 1.66e-10 Depression; CRC cis rs7666738 0.830 rs13110903 chr4:98946373 A/G cg05340658 chr4:99064831 C4orf37 0.61 9.54 0.47 3.45e-19 Colonoscopy-negative controls vs population controls; CRC cis rs1832871 0.683 rs56197409 chr6:158684338 A/G cg07165851 chr6:158734300 TULP4 0.61 7.72 0.39 1.41e-13 Height; CRC cis rs9811920 0.609 rs793465 chr3:99627750 A/G cg07805332 chr3:99536008 MIR548G;C3orf26 -0.51 -7.68 -0.39 1.84e-13 Axial length; CRC cis rs995000 0.931 rs583609 chr1:62916796 T/C cg19896129 chr1:63156450 NA 0.43 6.62 0.34 1.5e-10 Triglyceride levels; CRC cis rs250677 0.687 rs42364 chr5:148438858 T/A cg23229984 chr5:148520753 ABLIM3 0.47 6.44 0.33 4.25e-10 Breast cancer; CRC cis rs9649213 1.000 rs9649213 chr7:98021211 A/G cg00277769 chr7:97922759 BAIAP2L1 0.39 6.1 0.32 3.01e-9 Prostate cancer (SNP x SNP interaction); CRC cis rs7762018 0.660 rs78181018 chr6:170096652 A/C cg24289452 chr6:170231220 NA -0.81 -6.87 -0.35 3.18e-11 Thiazide-induced adverse metabolic effects in hypertensive patients; CRC cis rs2228479 1.000 rs11642267 chr16:89957635 T/C cg19635926 chr16:89946313 TCF25 0.65 6.21 0.32 1.55e-9 Skin colour saturation; CRC cis rs9292777 0.777 rs16869930 chr5:40394954 G/A cg09067459 chr5:40385259 NA -0.57 -9.39 -0.46 1.01e-18 Crohn's disease;Multiple sclerosis; CRC cis rs9659323 0.804 rs10923722 chr1:119543486 C/T cg26570165 chr1:119541833 NA -0.43 -7.15 -0.37 5.81e-12 Body mass index; CRC cis rs2839186 0.500 rs13049893 chr21:47707054 C/T cg12516959 chr21:47718080 NA -0.45 -7.36 -0.38 1.46e-12 Testicular germ cell tumor; CRC trans rs75804782 1.000 rs75804782 chr2:239316043 T/C cg01134436 chr17:81009848 B3GNTL1 0.73 6.56 0.34 2.03e-10 Morning vs. evening chronotype;Chronotype; CRC cis rs1707322 1.000 rs10789479 chr1:46352500 T/C cg06784218 chr1:46089804 CCDC17 0.59 10.47 0.5 2.44e-22 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs2243480 1.000 rs7794661 chr7:65389730 T/C cg18252515 chr7:66147081 NA -1.09 -12.71 -0.57 2.3e-30 Diabetic kidney disease; CRC cis rs2354432 0.607 rs3820130 chr1:146724003 A/G cg25205988 chr1:146714368 CHD1L -1.17 -9.75 -0.47 6.94e-20 Mitochondrial DNA levels; CRC cis rs9926296 0.546 rs7187436 chr16:89845110 A/T cg03388025 chr16:89894329 SPIRE2 0.43 8.65 0.43 2.3e-16 Vitiligo; CRC trans rs2303319 0.504 rs12470830 chr2:162429996 C/T cg11875773 chr22:50468633 TTLL8 -0.7 -6.07 -0.32 3.62e-9 Cognitive function; CRC cis rs561341 1.000 rs508192 chr17:30315147 C/T cg23018236 chr17:30244563 NA 0.61 7.09 0.36 8.34e-12 Hip circumference adjusted for BMI; CRC cis rs4821897 0.514 rs739141 chr22:39824450 A/G cg05872129 chr22:39784769 NA 0.51 9.41 0.46 8.93e-19 IgG glycosylation; CRC cis rs6743376 0.556 rs2515399 chr2:113819451 G/T cg09040174 chr2:113837401 NA 0.44 6.44 0.33 4.3e-10 Inflammatory biomarkers; CRC trans rs783540 0.900 rs4778686 chr15:83310835 C/T cg18393722 chr15:85113863 UBE2QP1 -0.4 -6.99 -0.36 1.54e-11 Schizophrenia; CRC trans rs3858526 0.920 rs11039698 chr11:5950907 C/T cg01505111 chr6:125621795 HDDC2 0.38 6.04 0.32 4.06e-9 DNA methylation (variation); CRC cis rs4700695 0.668 rs253214 chr5:65499401 A/G cg21114390 chr5:65439923 SFRS12 -0.61 -8.33 -0.42 2.14e-15 Facial morphology (factor 19); CRC cis rs1552244 0.816 rs17050701 chr3:10041554 A/G cg18598329 chr3:10140678 FANCD2;C3orf24 -0.81 -10.69 -0.51 4.35e-23 Alzheimer's disease; CRC cis rs17253792 0.749 rs74979160 chr14:56097568 G/A cg01858014 chr14:56050164 KTN1 -0.87 -7.23 -0.37 3.34e-12 Putamen volume; CRC cis rs72945132 0.825 rs12287883 chr11:70122369 C/T cg14191688 chr11:70257035 CTTN 0.42 5.85 0.31 1.18e-8 Coronary artery disease; CRC cis rs7615952 0.673 rs9821905 chr3:125620850 A/G cg05084668 chr3:125655381 ALG1L 0.83 10.46 0.5 2.67e-22 Blood pressure (smoking interaction); CRC cis rs875971 0.545 rs3735147 chr7:65970528 A/C cg18876405 chr7:65276391 NA 0.45 6.28 0.33 1.08e-9 Aortic root size; CRC cis rs7085104 0.700 rs743572 chr10:104597152 A/G cg15744005 chr10:104629667 AS3MT -0.36 -7.62 -0.39 2.76e-13 Immature fraction of reticulocytes;Schizophrenia; CRC trans rs10506458 0.915 rs56321182 chr12:63392023 C/T cg03429785 chr15:59498649 MYO1E;LDHAL6B -1.44 -21.4 -0.76 2.91e-64 Hemostatic factors and hematological phenotypes; CRC cis rs798554 0.797 rs35957220 chr7:2812632 C/G cg14895029 chr7:2775587 GNA12 -0.46 -6.45 -0.34 3.88e-10 Height; CRC cis rs10464366 0.571 rs13233049 chr7:39187536 C/T cg21665744 chr7:39171113 POU6F2 0.44 5.9 0.31 9.26e-9 IgG glycosylation; CRC cis rs1218582 0.741 rs10908446 chr1:154869559 G/A cg03351412 chr1:154909251 PMVK 0.55 8.8 0.44 7.77e-17 Prostate cancer; CRC trans rs1941687 0.702 rs9956636 chr18:31304974 C/T cg27147174 chr7:100797783 AP1S1 -0.37 -6.05 -0.32 4.01e-9 Subjective well-being (multi-trait analysis);Subjective well-being; CRC cis rs1005277 0.683 rs7923868 chr10:37989766 T/C cg00409905 chr10:38381863 ZNF37A -0.61 -9.88 -0.48 2.42e-20 Extrinsic epigenetic age acceleration; CRC cis rs8180040 0.966 rs7651762 chr3:47470484 G/A cg27129171 chr3:47204927 SETD2 -0.59 -9.05 -0.45 1.25e-17 Colorectal cancer; CRC cis rs9916302 0.904 rs4794814 chr17:37696852 G/A cg15445000 chr17:37608096 MED1 0.43 9.48 0.46 5.38e-19 Glomerular filtration rate (creatinine); CRC cis rs9900972 0.842 rs2009196 chr17:76870581 C/G cg20937029 chr17:76870563 TIMP2 -0.43 -6.27 -0.33 1.1e-9 Obesity-related traits; CRC cis rs7113874 0.569 rs10160805 chr11:8600393 C/T cg20771178 chr11:8615675 STK33 0.35 5.74 0.3 2.17e-8 Body mass index in physically active individuals;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs7727544 0.647 rs72793280 chr5:131562900 C/T cg04518342 chr5:131593106 PDLIM4 0.38 6.65 0.34 1.24e-10 Blood metabolite levels; CRC cis rs801193 0.591 rs721717 chr7:66130292 G/T cg00343986 chr7:65444356 GUSB -0.45 -6.2 -0.32 1.7e-9 Aortic root size; CRC cis rs2011503 1.000 rs76095338 chr19:19633908 G/A cg11584989 chr19:19387371 SF4 0.57 6.39 0.33 5.7e-10 Bipolar disorder; CRC cis rs9916302 0.904 rs10221223 chr17:37489100 T/G cg00129232 chr17:37814104 STARD3 0.55 8.05 0.41 1.49e-14 Glomerular filtration rate (creatinine); CRC cis rs10504229 0.683 rs11787247 chr8:58131528 G/T cg02725872 chr8:58115012 NA -0.64 -11.55 -0.54 3.85e-26 Developmental language disorder (linguistic errors); CRC cis rs7215564 0.908 rs80183474 chr17:78655070 T/A cg09596252 chr17:78655493 RPTOR 0.54 5.7 0.3 2.7e-8 Myopia (pathological); CRC cis rs921968 0.613 rs2556388 chr2:219541056 T/C cg02176678 chr2:219576539 TTLL4 -0.46 -7.28 -0.37 2.49e-12 Mean corpuscular hemoglobin concentration; CRC cis rs2898681 0.519 rs73814886 chr4:53733251 C/T cg00338735 chr4:53728038 RASL11B 0.45 6.02 0.31 4.75e-9 Optic nerve measurement (cup area); CRC cis rs1005277 0.579 rs2505248 chr10:38459097 A/G cg00409905 chr10:38381863 ZNF37A -0.68 -11.28 -0.53 3.67e-25 Extrinsic epigenetic age acceleration; CRC cis rs9488822 0.676 rs11153593 chr6:116335131 C/A cg15226275 chr6:116381976 FRK 0.3 8.56 0.43 4.52e-16 Cholesterol, total;LDL cholesterol; CRC cis rs7584330 0.541 rs10202181 chr2:238352099 A/G cg16989719 chr2:238392110 NA -0.44 -8.0 -0.4 2.11e-14 Prostate cancer; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg22566565 chr10:131909018 NA 0.49 7.0 0.36 1.47e-11 Response to antipsychotic treatment; CRC trans rs11031096 0.702 rs183484 chr11:4141132 C/A cg22978087 chr8:24814126 NEFL 0.33 6.08 0.32 3.36e-9 Mean corpuscular volume;Mean corpuscular hemoglobin; CRC cis rs10504229 0.728 rs17215676 chr8:58152915 G/T cg05313129 chr8:58192883 C8orf71 -0.47 -6.18 -0.32 1.94e-9 Developmental language disorder (linguistic errors); CRC cis rs72634258 0.945 rs6577459 chr1:8100173 G/T cg26816564 chr1:7831052 VAMP3 0.55 6.16 0.32 2.15e-9 Inflammatory bowel disease; CRC cis rs13191362 0.938 rs28360532 chr6:162997477 T/C cg23758597 chr6:163146217 PARK2 -0.55 -6.12 -0.32 2.61e-9 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC trans rs12210905 1.000 rs6938397 chr6:27231224 C/G cg05005425 chr1:167687389 NA 0.62 6.29 0.33 1.03e-9 Hip circumference adjusted for BMI; CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg11427898 chr15:38544983 SPRED1 0.34 6.07 0.32 3.48e-9 Obesity-related traits; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg05227434 chr19:47249937 FKRP;STRN4 0.39 5.96 0.31 6.54e-9 Intelligence (multi-trait analysis); CRC cis rs11212617 1.000 rs645485 chr11:108168863 A/G cg14761454 chr11:108092087 ATM;NPAT 0.42 6.19 0.32 1.74e-9 Response to metformin in type 2 diabetes (glycemic); CRC cis rs826838 1.000 rs55828987 chr12:39056421 A/C cg13010199 chr12:38710504 ALG10B 0.44 5.82 0.31 1.4e-8 Heart rate; CRC cis rs473651 0.935 rs35080527 chr2:239351387 T/C cg21699342 chr2:239360505 ASB1 0.58 10.5 0.5 1.99e-22 Multiple system atrophy; CRC cis rs2276314 1.000 rs4573997 chr18:33552568 C/T cg05985134 chr18:33552581 C18orf21 0.52 7.13 0.37 6.35e-12 Endometriosis;Drug-induced torsades de pointes; CRC cis rs6912958 0.712 rs4587138 chr6:88356915 G/C cg12350822 chr6:88032061 C6orf162;GJB7 -0.31 -5.96 -0.31 6.32e-9 Monocyte percentage of white cells; CRC cis rs7258465 0.965 rs7256534 chr19:18586791 C/T cg06953865 chr19:18549723 ISYNA1 -0.38 -5.77 -0.3 1.85e-8 Breast cancer; CRC cis rs4713118 0.696 rs2394002 chr6:27748015 G/A cg15786705 chr6:28176104 NA 0.53 6.98 0.36 1.64e-11 Parkinson's disease; CRC cis rs853679 0.517 rs3757187 chr6:28107654 T/C cg15845792 chr6:28175446 NA 1.01 13.54 0.6 1.59e-33 Depression; CRC cis rs1552244 1.000 rs113522867 chr3:10154503 T/C cg02579736 chr3:10068473 FANCD2;CIDECP 1.03 13.5 0.6 2.34e-33 Alzheimer's disease; CRC cis rs3018066 0.831 rs10008773 chr4:106947203 T/C cg01869342 chr4:106983673 TBCK 0.4 6.12 0.32 2.68e-9 Cancer; CRC cis rs933688 1.000 rs6865495 chr5:90746424 G/A cg02339078 chr5:90679543 LOC100129716;ARRDC3 0.93 15.43 0.65 8.56e-41 Smoking behavior; CRC cis rs7517126 0.614 rs7530627 chr1:197044480 T/C cg13682187 chr1:196946512 CFHR5 0.47 7.35 0.38 1.56e-12 Blood protein levels; CRC cis rs17711722 0.523 rs365896 chr7:65510697 A/G cg18876405 chr7:65276391 NA -0.5 -8.43 -0.42 1.1e-15 Calcium levels; CRC cis rs10971721 0.822 rs10971803 chr9:33933287 C/A cg13495928 chr9:33750294 PRSS3 0.56 5.95 0.31 6.96e-9 Body mass index; CRC cis rs7568458 0.684 rs6731700 chr2:85760991 C/G cg02493740 chr2:85810744 VAMP5 -0.55 -8.3 -0.42 2.69e-15 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); CRC trans rs7267979 0.966 rs2424715 chr20:25420077 A/G cg17903999 chr18:56338584 MALT1 -0.42 -6.98 -0.36 1.6e-11 Liver enzyme levels (alkaline phosphatase); CRC cis rs7306456 0.623 rs10902513 chr12:132693487 A/G cg00155535 chr12:132671473 NA 0.45 7.66 0.39 2.11e-13 Anti-saccade response; CRC cis rs6952808 0.771 rs10244946 chr7:1921068 A/G cg20295408 chr7:1910781 MAD1L1 0.38 5.66 0.3 3.27e-8 Bipolar disorder and schizophrenia; CRC trans rs360798 0.512 rs2058566 chr2:63179076 C/T cg05376469 chr2:102649931 NA -0.37 -5.97 -0.31 6.3e-9 Coronary artery disease; CRC cis rs780096 0.506 rs1647265 chr2:27692261 A/G cg27432699 chr2:27873401 GPN1 -0.52 -7.96 -0.4 2.91e-14 Total body bone mineral density; CRC cis rs7647973 1.000 rs73088137 chr3:49448423 G/A cg07636037 chr3:49044803 WDR6 -0.64 -7.44 -0.38 8.68e-13 Menarche (age at onset); CRC cis rs1552244 0.515 rs67342818 chr3:10166406 G/A cg10729496 chr3:10149963 C3orf24 0.48 5.61 0.3 4.19e-8 Alzheimer's disease; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg00496025 chr7:73038982 MLXIPL 0.37 6.05 0.32 3.96e-9 Liver disease severity in Alagille syndrome; CRC cis rs13064411 0.696 rs9839921 chr3:113199093 G/C cg10517650 chr3:113235015 CCDC52 -0.41 -7.18 -0.37 4.55e-12 Response to simvastatin treatment (PCSK9 protein level change); CRC cis rs6860806 0.507 rs272882 chr5:131669161 G/T cg04518342 chr5:131593106 PDLIM4 0.42 6.94 0.36 2.03e-11 Breast cancer; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg24942285 chr3:47866555 DHX30 0.49 6.77 0.35 5.95e-11 Anxiety disorder; CRC cis rs17345786 0.817 rs11720560 chr3:101328484 C/T cg12386194 chr3:101231763 SENP7 0.54 6.93 0.36 2.25e-11 Colonoscopy-negative controls vs population controls; CRC cis rs2463822 1.000 rs7481995 chr11:62129312 G/C cg06239285 chr11:62104954 ASRGL1 0.99 11.2 0.53 7.23e-25 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs2749592 0.550 rs7917262 chr10:37874602 A/C cg25517755 chr10:38738941 LOC399744 0.41 5.91 0.31 8.44e-9 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs1707322 0.752 rs6658700 chr1:46160260 C/T cg03146154 chr1:46216737 IPP 0.67 9.73 0.47 7.77e-20 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs853679 0.550 rs1233704 chr6:28166923 A/G cg23161317 chr6:28129485 ZNF389 -0.43 -5.69 -0.3 2.8e-8 Depression; CRC cis rs10791323 0.720 rs2851117 chr11:133705905 A/G cg14349672 chr11:133703707 NA 0.35 5.78 0.3 1.71e-8 Childhood ear infection; CRC cis rs10751667 0.961 rs6597953 chr11:991099 G/A ch.11.42038R chr11:967971 AP2A2 0.7 11.72 0.54 9.41e-27 Alzheimer's disease (late onset); CRC cis rs2836974 0.644 rs2410123 chr21:40700093 C/T cg11890956 chr21:40555474 PSMG1 -0.8 -12.49 -0.57 1.5e-29 Cognitive function; CRC cis rs11229555 0.645 rs12295551 chr11:58188983 T/C cg15696309 chr11:58395628 NA -0.82 -10.31 -0.49 8.59e-22 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; CRC cis rs6743226 0.840 rs6747036 chr2:242227054 T/C cg10021735 chr2:242295487 FARP2 0.45 6.37 0.33 6.31e-10 Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI in non-smokers; CRC cis rs9311474 0.508 rs2878628 chr3:52584715 C/T cg08222913 chr3:52553049 STAB1 0.34 6.22 0.32 1.54e-9 Electroencephalogram traits; CRC cis rs7917772 0.582 rs10786683 chr10:104320476 G/A cg11453585 chr10:104263688 ACTR1A;SUFU 0.82 15.45 0.65 7.2e-41 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC cis rs8114671 0.562 rs1018447 chr20:33401707 A/G cg07148914 chr20:33460835 GGT7 -0.39 -6.52 -0.34 2.68e-10 Height; CRC cis rs2739330 0.731 rs2000468 chr22:24241611 G/T cg16132339 chr22:24313637 DDTL;DDT 0.58 9.21 0.45 3.96e-18 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs4727027 0.868 rs10952799 chr7:148840772 C/T cg12479418 chr7:148823350 ZNF425;ZNF398 0.45 6.04 0.32 4.19e-9 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC cis rs7224685 0.501 rs2054038 chr17:4014391 A/C cg05562828 chr17:3906858 NA 0.57 9.75 0.47 6.53e-20 Type 2 diabetes; CRC cis rs6088580 0.634 rs4142007 chr20:32990050 G/T cg24642439 chr20:33292090 TP53INP2 -0.38 -6.39 -0.33 5.8e-10 Glomerular filtration rate (creatinine); CRC trans rs66759488 0.739 rs10851451 chr15:47608991 A/G cg19328814 chr18:14132536 ZNF519 -0.48 -6.69 -0.35 9.4e-11 Lung cancer; CRC cis rs2070677 0.708 rs12762259 chr10:135350365 C/T cg20169779 chr10:135381914 SYCE1 0.78 11.28 0.53 3.59e-25 Gout; CRC cis rs4969178 0.930 rs11077363 chr17:76397309 C/T cg20026190 chr17:76395443 PGS1 0.4 6.2 0.32 1.73e-9 HDL cholesterol levels; CRC cis rs853679 0.546 rs200948 chr6:27835272 T/C cg26587870 chr6:27730563 NA -0.6 -5.91 -0.31 8.73e-9 Depression; CRC cis rs875971 0.965 rs28682868 chr7:65689809 C/T cg18912574 chr7:65842487 NCRNA00174 -0.37 -6.48 -0.34 3.39e-10 Aortic root size; CRC cis rs9467711 0.606 rs9357006 chr6:26364628 A/C cg14345882 chr6:26364793 BTN3A2 0.65 5.73 0.3 2.32e-8 Autism spectrum disorder or schizophrenia; CRC cis rs7781266 0.842 rs62470027 chr7:133290717 G/A cg03336402 chr7:133662267 EXOC4 0.45 5.71 0.3 2.56e-8 Educational attainment (college completion); CRC cis rs11122272 0.735 rs2790884 chr1:231531932 A/G cg06096015 chr1:231504339 EGLN1 0.41 6.04 0.32 4.05e-9 Hemoglobin concentration; CRC cis rs968567 0.817 rs61896141 chr11:61556039 A/C cg21709803 chr11:61594965 FADS2 -0.6 -7.22 -0.37 3.73e-12 Blood metabolite levels;Rheumatoid arthritis;Vitiligo;Glycerophospholipid levels; CRC cis rs6951245 0.872 rs76161580 chr7:1100307 G/T cg04025307 chr7:1156635 C7orf50 0.64 6.81 0.35 4.53e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs7119 0.679 rs12914932 chr15:77839051 G/A cg27398640 chr15:77910606 LINGO1 -0.43 -7.28 -0.37 2.42e-12 Type 2 diabetes; CRC cis rs2404602 0.692 rs12594556 chr15:77165363 G/A cg03037974 chr15:76606532 NA 0.68 11.55 0.54 4.06e-26 Blood metabolite levels; CRC cis rs7216064 0.906 rs7223643 chr17:65830282 A/G cg12091567 chr17:66097778 LOC651250 -0.66 -7.94 -0.4 3.19e-14 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CRC cis rs4073416 0.542 rs7140695 chr14:65929132 T/C cg03016385 chr14:66212404 NA -0.43 -5.94 -0.31 7.31e-9 N-glycan levels; CRC cis rs10979 1.000 rs13197332 chr6:143888095 T/A cg25407410 chr6:143891975 LOC285740 -0.8 -13.23 -0.59 2.41e-32 Hypospadias; CRC cis rs9611565 0.694 rs5758389 chr22:41941749 T/C cg03806693 chr22:41940476 POLR3H -0.9 -12.21 -0.56 1.54e-28 Vitiligo; CRC cis rs12681288 0.578 rs56702775 chr8:968860 G/A cg08648136 chr8:956695 NA 0.37 6.45 0.33 4.06e-10 Schizophrenia; CRC cis rs9916302 0.904 rs2303316 chr17:37704217 A/G cg00129232 chr17:37814104 STARD3 -0.56 -8.39 -0.42 1.45e-15 Glomerular filtration rate (creatinine); CRC trans rs11146838 1 rs11146838 chr10:39149977 A/T cg23533926 chr12:111358616 MYL2 -0.6 -9.32 -0.46 1.73e-18 Breast cancer; CRC cis rs6089829 1.000 rs6089828 chr20:61668998 C/T cg08564027 chr20:61660810 NA 0.78 13.71 0.6 3.6e-34 Prostate cancer (SNP x SNP interaction); CRC cis rs12692738 0.526 rs355842 chr2:165622669 C/T cg03182029 chr2:165697222 COBLL1 0.51 5.98 0.31 5.74e-9 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);Waist-to-hip ratio adjusted for BMI in non-smokers;Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction);Waist-to-hip ratio adjusted for body mass index; CRC cis rs875971 0.862 rs11760844 chr7:65739883 C/G cg18252515 chr7:66147081 NA 0.4 5.77 0.3 1.82e-8 Aortic root size; CRC cis rs9381040 0.655 rs9381029 chr6:41026453 G/C cg03644281 chr6:41068752 NFYA;LOC221442 -0.44 -6.35 -0.33 7.11e-10 Alzheimer's disease (late onset); CRC cis rs2223471 0.719 rs2744485 chr6:50772616 C/G cg03432817 chr6:50765336 NA 0.43 6.93 0.36 2.24e-11 Subcutaneous adipose tissue; CRC cis rs7769051 0.522 rs6927991 chr6:133113888 T/G cg07930552 chr6:133119739 C6orf192 0.87 6.92 0.36 2.31e-11 Type 2 diabetes nephropathy; CRC cis rs425277 0.606 rs262664 chr1:2083537 G/C cg24578937 chr1:2090814 PRKCZ 0.42 7.59 0.39 3.42e-13 Height; CRC cis rs3820068 0.581 rs6693694 chr1:15980135 G/T cg27534772 chr1:16042836 PLEKHM2 0.54 10.15 0.49 3.05e-21 Systolic blood pressure; CRC cis rs1881797 1.000 rs12071797 chr1:247686871 A/G cg21399703 chr1:247681439 NA 0.47 7.65 0.39 2.24e-13 Acute lymphoblastic leukemia (childhood); CRC cis rs172166 0.694 rs188105 chr6:28071393 C/T cg15786705 chr6:28176104 NA 0.63 8.99 0.44 2.02e-17 Cardiac Troponin-T levels; CRC cis rs9487051 0.676 rs2222392 chr6:109602303 T/C cg01475377 chr6:109611718 NA -0.39 -6.87 -0.35 3.13e-11 Reticulocyte fraction of red cells; CRC cis rs10876993 0.890 rs774891 chr12:58068571 G/A cg18357645 chr12:58087776 OS9 0.6 8.33 0.42 2.23e-15 Celiac disease or Rheumatoid arthritis; CRC cis rs3754214 0.823 rs10888579 chr1:150261925 C/T cg15654264 chr1:150340011 RPRD2 -0.39 -5.8 -0.3 1.58e-8 Cerebrospinal fluid biomarker levels; CRC cis rs7072216 0.763 rs2274246 chr10:100175060 C/T cg26618903 chr10:100175079 PYROXD2 -0.55 -8.99 -0.44 2.03e-17 Metabolite levels; CRC cis rs6912958 0.559 rs242287 chr6:88071825 C/T cg08069147 chr6:88032118 GJB7;C6orf162 0.66 10.25 0.49 1.46e-21 Monocyte percentage of white cells; CRC cis rs13256369 0.950 rs13270006 chr8:8574197 C/A cg06671706 chr8:8559999 CLDN23 0.56 8.37 0.42 1.67e-15 Obesity-related traits; CRC cis rs6088813 0.857 rs6142378 chr20:33997291 T/A cg14752227 chr20:34000481 UQCC -0.37 -5.68 -0.3 3.01e-8 Height; CRC cis rs9814567 1.000 rs6804770 chr3:134230234 A/T cg06541857 chr3:134203789 ANAPC13;CEP63 -0.41 -6.22 -0.32 1.48e-9 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg03236992 chr16:78133292 WWOX 0.42 6.33 0.33 7.9e-10 Intelligence (multi-trait analysis); CRC cis rs9916302 0.851 rs4390625 chr17:37620347 A/G cg00129232 chr17:37814104 STARD3 -0.55 -8.17 -0.41 6.79e-15 Glomerular filtration rate (creatinine); CRC cis rs1580019 0.587 rs1597555 chr7:32546118 T/G cg06627557 chr7:32535165 LSM5;AVL9 0.97 18.91 0.72 1.7e-54 Cognitive ability; CRC cis rs597539 0.652 rs513359 chr11:68669496 A/T cg06028808 chr11:68637592 NA -0.42 -6.74 -0.35 7.16e-11 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs12476592 0.516 rs6734648 chr2:63801525 A/G cg10828910 chr2:63850056 LOC388955 0.49 6.11 0.32 2.79e-9 Childhood ear infection; CRC cis rs6952808 0.529 rs73038442 chr7:2139457 C/T cg02951883 chr7:2050386 MAD1L1 -0.67 -10.49 -0.5 2.16e-22 Bipolar disorder and schizophrenia; CRC cis rs7113874 0.589 rs10769908 chr11:8484089 A/G cg02811074 chr11:8615871 STK33 0.37 6.22 0.32 1.51e-9 Body mass index in physically active individuals;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs501120 1.000 rs607363 chr10:44761623 A/G cg09554077 chr10:44749378 NA 0.78 11.96 0.55 1.33e-27 Coronary artery disease;Coronary heart disease; CRC cis rs4713118 0.662 rs9393881 chr6:28023751 C/G cg21251018 chr6:28226885 NKAPL 0.46 6.46 0.34 3.67e-10 Parkinson's disease; CRC trans rs1656966 1.000 rs1656966 chr3:186466252 C/T cg26824705 chr1:20834772 MUL1 0.4 6.16 0.32 2.14e-9 Myopia (pathological); CRC trans rs6076960 0.652 rs6085467 chr20:6259004 T/C cg24759859 chr6:86352639 SYNCRIP 0.47 6.61 0.34 1.54e-10 Smooth-surface caries; CRC cis rs6570726 0.791 rs6570692 chr6:145904401 T/A cg13319975 chr6:146136371 FBXO30 -0.42 -6.28 -0.33 1.04e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs9611519 0.780 rs5751072 chr22:41656509 C/T cg03806693 chr22:41940476 POLR3H -0.62 -8.79 -0.44 8.66e-17 Neuroticism; CRC cis rs8141529 0.732 rs5762784 chr22:29171298 C/T cg02153584 chr22:29168773 CCDC117 0.55 8.24 0.41 4.27e-15 Lymphocyte counts; CRC cis rs1707322 0.686 rs11211179 chr1:46228082 A/C cg03146154 chr1:46216737 IPP 0.59 8.53 0.43 5.29e-16 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs875971 0.862 rs10282433 chr7:65721439 G/A cg11764359 chr7:65958608 NA -0.61 -9.29 -0.46 2.21e-18 Aortic root size; CRC cis rs7119 0.717 rs12901471 chr15:77818992 A/G cg27398640 chr15:77910606 LINGO1 -0.43 -7.44 -0.38 9.02e-13 Type 2 diabetes; CRC cis rs4718428 1.000 rs12534637 chr7:66327654 G/C cg25985355 chr7:65971099 NA -0.34 -5.68 -0.3 2.94e-8 Corneal structure; CRC cis rs4930103 0.602 rs170101 chr11:2008936 C/T cg23202291 chr11:1979235 NA 0.53 7.63 0.39 2.62e-13 DNA methylation (parent-of-origin);DNA methylation (variation); CRC cis rs7666738 0.830 rs6831588 chr4:98977356 T/G cg05340658 chr4:99064831 C4orf37 0.6 9.35 0.46 1.41e-18 Colonoscopy-negative controls vs population controls; CRC cis rs10876993 0.890 rs1082502 chr12:58035706 C/T cg15848620 chr12:58087721 OS9 -0.57 -7.78 -0.39 9.56e-14 Celiac disease or Rheumatoid arthritis; CRC cis rs4363385 0.747 rs1415959 chr1:152973690 C/T cg25856811 chr1:152973957 SPRR3 0.24 6.65 0.34 1.25e-10 Inflammatory skin disease; CRC cis rs739401 0.572 rs739400 chr11:3016520 G/A cg08508325 chr11:3079039 CARS -0.5 -9.42 -0.46 8.27e-19 Longevity; CRC cis rs10046574 0.831 rs78220593 chr7:135166787 T/C cg27474649 chr7:135195673 CNOT4 0.69 5.7 0.3 2.61e-8 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs2576037 0.901 rs2060416 chr18:44576240 G/C cg23996704 chr18:44553084 KATNAL2 0.3 5.84 0.31 1.27e-8 Personality dimensions; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg11200644 chr18:72265018 LOC400657 0.41 6.15 0.32 2.29e-9 Intelligence (multi-trait analysis); CRC cis rs6502050 0.799 rs6502066 chr17:80103737 T/C cg19223190 chr17:80058835 NA 0.4 6.36 0.33 6.88e-10 Life satisfaction; CRC cis rs4713118 0.516 rs4713142 chr6:28106347 T/G cg02631126 chr6:28058918 ZSCAN12L1 0.29 5.89 0.31 9.41e-9 Parkinson's disease; CRC cis rs4713675 0.584 rs7770465 chr6:33674156 G/C cg14003231 chr6:33640908 ITPR3 0.47 7.41 0.38 1.09e-12 Plateletcrit; CRC cis rs2836974 0.899 rs68004583 chr21:40659587 T/C cg11890956 chr21:40555474 PSMG1 1.09 19.98 0.74 1e-58 Cognitive function; CRC cis rs12701220 0.655 rs7784403 chr7:1153077 G/A cg02733842 chr7:1102375 C7orf50 -0.65 -8.0 -0.4 2.2e-14 Bronchopulmonary dysplasia; CRC cis rs2742540 0.503 rs7106539 chr11:8897533 T/G cg12365402 chr11:9010492 NRIP3 -0.37 -6.42 -0.33 4.76e-10 Hematocrit; CRC cis rs2976388 0.609 rs2244152 chr8:143784885 C/A cg04969067 chr8:143858791 LYNX1 0.44 7.45 0.38 8.37e-13 Urinary tract infection frequency; CRC cis rs4889855 0.530 rs4303599 chr17:78566700 C/T cg16591659 chr17:78472290 NA 0.4 5.71 0.3 2.47e-8 Fractional excretion of uric acid; CRC cis rs7615952 0.599 rs1875683 chr3:125732481 C/G cg02807482 chr3:125708958 NA -0.46 -5.95 -0.31 6.78e-9 Blood pressure (smoking interaction); CRC cis rs853679 0.517 rs9368553 chr6:28082265 T/C cg12172441 chr6:28176163 NA 0.62 7.27 0.37 2.56e-12 Depression; CRC cis rs763121 0.853 rs2413547 chr22:39107338 A/G cg06544989 chr22:39130855 UNC84B 0.45 6.84 0.35 3.88e-11 Menopause (age at onset); CRC trans rs7267979 1.000 rs2258617 chr20:25274318 C/T cg17903999 chr18:56338584 MALT1 -0.42 -6.94 -0.36 2.05e-11 Liver enzyme levels (alkaline phosphatase); CRC cis rs875971 1.000 rs2420591 chr7:65912381 T/C cg18912574 chr7:65842487 NCRNA00174 0.36 6.1 0.32 2.97e-9 Aortic root size; CRC cis rs3996993 0.597 rs62412891 chr6:52713902 C/T cg20803780 chr6:52668592 GSTA1 0.4 7.0 0.36 1.42e-11 Hemoglobin concentration; CRC cis rs2979489 0.891 rs6982511 chr8:30355513 G/T cg26383811 chr8:30366931 RBPMS -0.71 -10.03 -0.48 7.59e-21 Mean corpuscular hemoglobin;Plateletcrit;Neutrophil count;Granulocyte count;Sum basophil neutrophil counts;Mean corpuscular volume;Myeloid white cell count;Sum neutrophil eosinophil counts; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg00598858 chr19:11545966 PRKCSH;CCDC151 0.44 6.2 0.32 1.66e-9 Intelligence (multi-trait analysis); CRC cis rs6835098 0.539 rs1383628 chr4:174194453 C/T cg08422745 chr4:174089978 GALNT7 -0.6 -9.21 -0.45 3.92e-18 Dementia and core Alzheimer's disease neuropathologic changes; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg11255230 chr18:60987808 BCL2 0.42 6.72 0.35 8.21e-11 Liver disease severity in Alagille syndrome; CRC cis rs950169 1.000 rs12903820 chr15:84723820 A/G cg03959625 chr15:84868606 LOC388152 0.41 6.08 0.32 3.27e-9 Schizophrenia; CRC cis rs6867032 0.527 rs1017924 chr5:1976187 C/T cg26168224 chr5:2018326 NA 0.78 11.19 0.53 7.54e-25 Gut microbiome composition (winter); CRC cis rs208520 0.690 rs12213575 chr6:66735989 A/G cg07460842 chr6:66804631 NA 1.06 14.74 0.63 4.07e-38 Exhaled nitric oxide output; CRC trans rs2303319 0.504 rs35304298 chr2:162617185 G/T cg12500891 chr11:57225987 NA -0.65 -6.05 -0.32 3.87e-9 Cognitive function; CRC cis rs6456156 0.716 rs6905911 chr6:167521624 C/T cg07741184 chr6:167504864 NA 0.47 7.96 0.4 2.77e-14 Primary biliary cholangitis; CRC cis rs9486715 0.758 rs9386528 chr6:96928514 G/A cg06623918 chr6:96969491 KIAA0776 -0.89 -14.02 -0.61 2.47e-35 Headache; CRC cis rs4746818 1.000 rs7091695 chr10:70964997 A/G cg11621586 chr10:70884670 VPS26A -0.87 -7.83 -0.4 6.84e-14 Left atrial antero-posterior diameter; CRC cis rs2228479 0.850 rs2283565 chr16:89827556 G/T cg06656553 chr16:89960601 TCF25 -0.7 -5.76 -0.3 1.93e-8 Skin colour saturation; CRC trans rs7615952 0.673 rs35955861 chr3:125626201 T/C cg07211511 chr3:129823064 LOC729375 -1.1 -12.68 -0.57 2.87e-30 Blood pressure (smoking interaction); CRC cis rs2072499 0.833 rs2251636 chr1:156202809 G/C cg06970220 chr1:156163860 SLC25A44 0.44 6.19 0.32 1.75e-9 Testicular germ cell tumor; CRC cis rs758324 0.947 rs4493667 chr5:131247218 G/T cg06307176 chr5:131281290 NA -0.44 -6.34 -0.33 7.41e-10 Alzheimer's disease in APOE e4- carriers; CRC cis rs11711311 1.000 rs9828449 chr3:113518602 T/C cg15478005 chr3:113465772 ATP6V1A;NAA50 0.43 5.88 0.31 9.92e-9 IgG glycosylation; CRC cis rs12479064 0.703 rs28382977 chr2:100018304 G/A cg14399236 chr2:99771627 LIPT1;TSGA10 -0.63 -7.98 -0.4 2.49e-14 Chronic sinus infection; CRC cis rs3806843 0.966 rs2563260 chr5:140137867 C/A cg16607685 chr5:140181889 PCDHA2;PCDHA1;PCDHA3 0.26 5.98 0.31 5.87e-9 Depressive symptoms (multi-trait analysis); CRC trans rs8002861 0.840 rs1819597 chr13:44429553 G/A cg17145862 chr1:211918768 LPGAT1 0.71 14.01 0.61 2.65e-35 Leprosy; CRC cis rs9309473 0.950 rs10169213 chr2:73787234 G/C cg20560298 chr2:73613845 ALMS1 -0.49 -6.0 -0.31 5.3e-9 Metabolite levels; CRC cis rs17433780 0.836 rs17434342 chr1:89505742 C/G cg09516651 chr1:89888402 LOC400759 -0.44 -6.72 -0.35 8.14e-11 Carotid intima media thickness; CRC cis rs8060686 0.545 rs76836953 chr16:68061763 G/C cg26727032 chr16:67993705 SLC12A4 -0.59 -6.66 -0.34 1.14e-10 HDL cholesterol;Metabolic syndrome; CRC cis rs6502050 0.835 rs8071737 chr17:80117537 T/C cg09264619 chr17:80180166 NA -0.35 -5.98 -0.31 5.97e-9 Life satisfaction; CRC cis rs35883536 0.626 rs34752753 chr1:101045193 T/G cg06223162 chr1:101003688 GPR88 -0.35 -6.49 -0.34 3.12e-10 Monocyte count; CRC cis rs1555322 0.505 rs591590 chr20:33866028 A/G cg08210727 chr20:33865349 NA -0.49 -6.27 -0.33 1.16e-9 Attention deficit hyperactivity disorder; CRC cis rs16975963 0.644 rs12462505 chr19:38138125 C/G cg15135657 chr19:38346511 NA -0.46 -6.37 -0.33 6.28e-10 Longevity; CRC trans rs916888 0.773 rs169201 chr17:44790203 A/G cg10053473 chr17:62856997 LRRC37A3 -0.8 -8.63 -0.43 2.74e-16 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs7811142 1.000 rs11761784 chr7:100039970 C/T cg00814883 chr7:100076585 TSC22D4 -0.7 -9.25 -0.45 2.94e-18 Platelet count; CRC cis rs2153535 0.580 rs9379213 chr6:8474945 G/A cg07606381 chr6:8435919 SLC35B3 0.67 10.7 0.51 4.01e-23 Motion sickness; CRC trans rs1814175 0.647 rs1404157 chr11:49917301 G/C cg15704280 chr7:45808275 SEPT13 -0.76 -12.41 -0.56 2.89e-29 Height; CRC cis rs17270561 0.609 rs1165211 chr6:25800922 T/C cg17691542 chr6:26056736 HIST1H1C 0.51 7.02 0.36 1.25e-11 Iron status biomarkers; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg18607418 chr19:15667338 NA 0.45 6.37 0.33 6.39e-10 Response to antipsychotic treatment; CRC cis rs68170813 0.559 rs6971774 chr7:106834139 A/G cg02696742 chr7:106810147 HBP1 -0.56 -6.47 -0.34 3.65e-10 Coronary artery disease; CRC cis rs7319311 0.965 rs9583488 chr13:111031352 G/A cg05272587 chr13:111038400 COL4A2 0.38 5.76 0.3 1.94e-8 Bipolar disorder and schizophrenia; CRC trans rs1728785 1.000 rs864742 chr16:68575309 T/C cg04657470 chr2:198365150 HSPE1;HSPD1 0.58 7.0 0.36 1.46e-11 Ulcerative colitis; CRC cis rs1008375 1.000 rs6854733 chr4:17640526 C/T cg16339924 chr4:17578868 LAP3 0.58 7.9 0.4 4.3e-14 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs832540 0.898 rs331497 chr5:56251660 G/T cg18230493 chr5:56204884 C5orf35 0.39 6.0 0.31 5.21e-9 Coronary artery disease; CRC cis rs12143943 0.934 rs868097 chr1:204580139 C/T cg17419461 chr1:204415978 PIK3C2B 0.36 5.66 0.3 3.3e-8 Cognitive performance; CRC trans rs1814175 0.645 rs11040671 chr11:49958776 G/A cg11707556 chr5:10655725 ANKRD33B -0.52 -10.05 -0.48 6.61e-21 Height; CRC cis rs10242455 1.000 rs17161692 chr7:98953863 A/G cg18809830 chr7:99032528 PTCD1 0.66 6.14 0.32 2.4e-9 Blood metabolite levels; CRC cis rs62244186 0.659 rs4682745 chr3:44508967 T/C cg10263370 chr3:44754102 ZNF502 -0.36 -5.92 -0.31 7.94e-9 Depressive symptoms; CRC cis rs28386778 0.799 rs2727322 chr17:61921706 G/A cg07362569 chr17:61921086 SMARCD2 0.37 5.71 0.3 2.47e-8 Prudent dietary pattern; CRC cis rs2404602 0.716 rs12441247 chr15:76812316 T/C cg03037974 chr15:76606532 NA 0.71 12.27 0.56 9.37e-29 Blood metabolite levels; CRC cis rs1448094 0.817 rs10863111 chr12:86330615 T/C cg25456477 chr12:86230367 RASSF9 0.34 5.74 0.3 2.14e-8 Major depressive disorder; CRC cis rs7301826 0.651 rs4759525 chr12:131316281 T/C cg11011512 chr12:131303247 STX2 0.39 5.85 0.31 1.18e-8 Plasma plasminogen activator levels; CRC cis rs8060686 0.545 rs3826164 chr16:68280317 A/G cg26727032 chr16:67993705 SLC12A4 0.59 6.35 0.33 7.31e-10 HDL cholesterol;Metabolic syndrome; CRC cis rs9796 0.553 rs7171437 chr15:41315168 G/A cg18705301 chr15:41695430 NDUFAF1 -0.5 -8.0 -0.4 2.16e-14 Menopause (age at onset); CRC cis rs477895 0.652 rs72920332 chr11:63947071 G/T cg05016508 chr11:63871570 FLRT1;MACROD1 0.55 7.05 0.36 1.04e-11 Mean platelet volume; CRC cis rs58235267 0.591 rs2162014 chr2:63345507 C/A cg24726965 chr2:63606136 C2orf86 -0.37 -5.75 -0.3 2.01e-8 Prostate-specific antigen levels (conditioned on lead SNPs); CRC trans rs61931739 0.534 rs4001713 chr12:34154195 A/C cg26384229 chr12:38710491 ALG10B -0.56 -7.07 -0.36 9.38e-12 Morning vs. evening chronotype; CRC cis rs7626444 0.585 rs860050 chr3:196474447 T/G cg12930392 chr3:196481615 PAK2 0.4 7.1 0.36 7.93e-12 Monocyte count; CRC cis rs1552244 0.572 rs12107622 chr3:10171898 T/A cg08888203 chr3:10149979 C3orf24 0.74 9.0 0.44 1.82e-17 Alzheimer's disease; CRC cis rs1005277 0.579 rs1740745 chr10:38520056 T/C cg00409905 chr10:38381863 ZNF37A -0.62 -10.29 -0.49 1.04e-21 Extrinsic epigenetic age acceleration; CRC trans rs2797160 0.602 rs4897150 chr6:125985540 C/T cg05039488 chr6:79577232 IRAK1BP1 -0.58 -9.26 -0.45 2.73e-18 Endometrial cancer; CRC trans rs7819412 0.594 rs17724226 chr8:10968926 C/T cg06636001 chr8:8085503 FLJ10661 -0.48 -7.28 -0.37 2.44e-12 Triglycerides; CRC cis rs4654899 1.000 rs6659152 chr1:21355841 C/G cg05370193 chr1:21551575 ECE1 0.36 5.76 0.3 1.91e-8 Superior frontal gyrus grey matter volume; CRC cis rs6502050 0.769 rs4789741 chr17:80119184 A/C cg13198984 chr17:80129470 CCDC57 0.46 8.04 0.41 1.6e-14 Life satisfaction; CRC cis rs6500395 1.000 rs2354578 chr16:48593298 T/C cg04672837 chr16:48644449 N4BP1 0.45 6.66 0.34 1.18e-10 Response to tocilizumab in rheumatoid arthritis; CRC cis rs7705042 0.865 rs166079 chr5:141528959 C/T cg08523384 chr5:141488047 NDFIP1 -0.32 -5.71 -0.3 2.48e-8 Asthma; CRC trans rs1005277 0.579 rs9299760 chr10:38377920 C/T cg11292332 chr7:45801988 SEPT13 -0.35 -6.21 -0.32 1.62e-9 Extrinsic epigenetic age acceleration; CRC cis rs9325144 0.555 rs4882284 chr12:38710459 C/T cg13010199 chr12:38710504 ALG10B -0.41 -6.04 -0.32 4.12e-9 Morning vs. evening chronotype; CRC cis rs3771570 1.000 rs62193209 chr2:242323523 A/G cg21155796 chr2:242212141 HDLBP 0.62 6.31 0.33 8.85e-10 Prostate cancer; CRC cis rs6502050 0.769 rs11658272 chr17:80084596 C/T cg22110888 chr17:80059540 CCDC57 -0.41 -6.39 -0.33 5.58e-10 Life satisfaction; CRC cis rs875971 1.000 rs12698523 chr7:65968113 C/G cg11764359 chr7:65958608 NA 0.63 10.25 0.49 1.39e-21 Aortic root size; CRC cis rs6502050 0.835 rs10163483 chr17:80110396 C/A cg02741985 chr17:80059408 CCDC57 0.43 7.15 0.37 5.66e-12 Life satisfaction; CRC cis rs4563143 0.675 rs34113156 chr19:29270822 G/A cg12756686 chr19:29218302 NA 0.61 9.08 0.45 1.01e-17 Methadone dose in opioid dependence; CRC cis rs12745968 0.624 rs6675753 chr1:93215596 T/C cg17283838 chr1:93427260 FAM69A -0.46 -6.29 -0.33 1e-9 Bipolar disorder and schizophrenia; CRC cis rs9611565 0.559 rs739136 chr22:42100275 C/T cg06634786 chr22:41940651 POLR3H -0.65 -7.44 -0.38 8.68e-13 Vitiligo; CRC cis rs6502050 0.830 rs8074436 chr17:80158422 A/G cg22110888 chr17:80059540 CCDC57 0.38 6.07 0.32 3.61e-9 Life satisfaction; CRC cis rs908922 0.523 rs4845786 chr1:152510144 A/G cg09873164 chr1:152488093 CRCT1 0.37 6.14 0.32 2.32e-9 Hair morphology; CRC cis rs9487051 0.768 rs463503 chr6:109525757 T/C cg21918786 chr6:109611834 NA -0.33 -5.7 -0.3 2.65e-8 Reticulocyte fraction of red cells; CRC cis rs11229555 0.609 rs12289198 chr11:58175057 T/C cg15696309 chr11:58395628 NA -0.81 -10.45 -0.5 2.9e-22 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; CRC cis rs2153535 0.580 rs2184585 chr6:8474168 G/A cg21535247 chr6:8435926 SLC35B3 0.5 7.53 0.38 4.89e-13 Motion sickness; CRC cis rs1364705 1.000 rs12677951 chr8:120226900 C/G cg27215916 chr8:120218354 NA -0.39 -5.66 -0.3 3.32e-8 Hippocampal atrophy; CRC cis rs9926296 0.533 rs10852623 chr16:89865242 T/C cg07648498 chr16:89883185 FANCA 0.41 5.79 0.3 1.66e-8 Vitiligo; CRC cis rs1801251 0.778 rs709933 chr2:233733144 G/A cg25237894 chr2:233734115 C2orf82 -0.63 -11.44 -0.53 9.57e-26 Coronary artery disease; CRC cis rs13191362 1.000 rs34725898 chr6:163127302 C/T cg23758597 chr6:163146217 PARK2 -0.66 -6.82 -0.35 4.46e-11 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs501120 0.584 rs1704228 chr10:44673050 C/T cg09554077 chr10:44749378 NA 0.69 7.83 0.4 6.91e-14 Coronary artery disease;Coronary heart disease; CRC cis rs10504229 0.610 rs6999661 chr8:58127391 C/G cg22535103 chr8:58192502 C8orf71 -0.7 -9.34 -0.46 1.47e-18 Developmental language disorder (linguistic errors); CRC trans rs10760279 0.685 rs10985975 chr9:126113272 G/C cg23210278 chr2:220439623 INHA 0.33 6.01 0.31 4.84e-9 Body mass index; CRC cis rs7552404 0.731 rs1770887 chr1:76401812 A/G cg22875332 chr1:76189707 ACADM -0.52 -6.57 -0.34 1.94e-10 Blood metabolite levels;Acylcarnitine levels; CRC cis rs9491140 0.539 rs10872287 chr6:124694573 T/G cg22366943 chr6:124882293 NKAIN2 0.56 7.44 0.38 9.1e-13 Neuroticism; CRC cis rs7909074 0.831 rs2065466 chr10:45384047 T/C cg05187965 chr10:45406764 TMEM72 -0.37 -8.52 -0.43 5.83e-16 Mean corpuscular volume; CRC cis rs6582630 0.622 rs11182005 chr12:38441292 G/A cg26384229 chr12:38710491 ALG10B -0.51 -7.34 -0.38 1.63e-12 Drug-induced liver injury (flucloxacillin); CRC trans rs3749237 1.000 rs11130214 chr3:49735746 C/G cg21659725 chr3:3221576 CRBN -0.56 -8.14 -0.41 8.43e-15 Resting heart rate; CRC cis rs2294693 0.947 rs9296351 chr6:40988102 T/C cg14769373 chr6:40998127 UNC5CL -0.5 -6.85 -0.35 3.65e-11 Gastric cancer;Non-cardia gastric cancer; CRC cis rs992157 0.585 rs62182795 chr2:219100202 C/T cg04731861 chr2:219085781 ARPC2 0.37 7.99 0.4 2.37e-14 Colorectal cancer; CRC trans rs6951245 0.706 rs28483034 chr7:1170171 C/A cg13565492 chr6:43139072 SRF -0.73 -8.15 -0.41 7.58e-15 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs897984 0.568 rs67456613 chr16:30888295 G/A cg02466173 chr16:30829666 NA -0.71 -9.17 -0.45 5.41e-18 Dementia with Lewy bodies; CRC cis rs1707322 0.865 rs785501 chr1:46579611 C/T cg06784218 chr1:46089804 CCDC17 -0.55 -9.66 -0.47 1.33e-19 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs10256972 0.591 rs10229680 chr7:1158565 C/T cg27094323 chr7:1216898 NA -0.36 -5.71 -0.3 2.57e-8 Longevity;Endometriosis; CRC cis rs2302190 0.882 rs7216856 chr17:56472295 C/T cg25885038 chr17:56607967 SEPT4 -0.38 -6.04 -0.32 4.14e-9 Vitamin D levels; CRC trans rs16846053 0.584 rs57840078 chr2:162402459 T/G cg18122310 chr12:50236657 BCDIN3D -0.72 -5.99 -0.31 5.65e-9 Blood osmolality (transformed sodium); CRC cis rs9322193 0.962 rs6914319 chr6:150127440 G/A cg13206674 chr6:150067644 NUP43 0.57 8.14 0.41 8.29e-15 Lung cancer; CRC cis rs67478160 0.619 rs11160761 chr14:104254856 A/T cg01849466 chr14:104193079 ZFYVE21 -0.48 -8.53 -0.43 5.59e-16 Schizophrenia; CRC cis rs28386778 0.897 rs8073515 chr17:61795328 A/C cg23090583 chr17:61904693 PSMC5;FTSJ3 1.02 19.1 0.73 3.07e-55 Prudent dietary pattern; CRC cis rs10992471 0.756 rs7027595 chr9:95131553 C/T cg14631576 chr9:95140430 CENPP -0.4 -7.44 -0.38 8.78e-13 Visceral adipose tissue/subcutaneous adipose tissue ratio; CRC cis rs9486715 0.867 rs4598081 chr6:96975227 A/G cg06623918 chr6:96969491 KIAA0776 1.03 20.97 0.76 1.31e-62 Headache; CRC cis rs40363 0.645 rs250631 chr16:3523215 G/C cg22508957 chr16:3507546 NAT15 0.65 10.11 0.49 4.07e-21 Tuberculosis; CRC cis rs2415984 0.622 rs2415997 chr14:46930446 A/C cg14871534 chr14:47121158 RPL10L -0.43 -6.16 -0.32 2.17e-9 Number of children ever born; CRC cis rs6761276 0.649 rs3827763 chr2:113831289 C/T cg24553058 chr2:113831203 IL1F10 -0.55 -8.7 -0.43 1.66e-16 Protein quantitative trait loci; CRC cis rs2933343 0.909 rs1683817 chr3:128651536 G/A cg11901034 chr3:128598214 ACAD9 -0.54 -6.43 -0.33 4.47e-10 IgG glycosylation; CRC cis rs9308731 0.644 rs1837366 chr2:111874629 C/T cg18646521 chr2:111875858 NA 0.39 6.12 0.32 2.62e-9 Chronic lymphocytic leukemia; CRC cis rs6815814 0.898 rs73236616 chr4:38789675 G/A cg06935464 chr4:38784597 TLR10 0.59 5.95 0.31 6.72e-9 Breast cancer; CRC cis rs2014572 0.967 rs8106734 chr19:57763546 C/T cg24459738 chr19:57751996 ZNF805 -0.55 -8.57 -0.43 4.18e-16 Hyperactive-impulsive symptoms; CRC cis rs4713118 0.629 rs203889 chr6:28021775 T/G cg02683197 chr6:28174875 NA 0.75 9.93 0.48 1.67e-20 Parkinson's disease; CRC cis rs10504229 0.639 rs66667899 chr8:58117065 C/T cg04204079 chr8:58130323 NA -0.45 -5.78 -0.3 1.71e-8 Developmental language disorder (linguistic errors); CRC cis rs7224610 0.898 rs4299205 chr17:53366146 T/G cg05452524 chr17:53343029 HLF -0.35 -5.64 -0.3 3.59e-8 Urate levels; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg25887236 chr18:74844781 MBP 0.4 6.48 0.34 3.43e-10 Liver disease severity in Alagille syndrome; CRC cis rs6502050 0.835 rs8071425 chr17:80117335 C/T cg19223190 chr17:80058835 NA -0.39 -6.24 -0.33 1.35e-9 Life satisfaction; CRC cis rs3785574 0.962 rs16947051 chr17:61790917 G/C cg25654072 chr17:61904446 PSMC5;FTSJ3 0.42 5.86 0.31 1.11e-8 Height; CRC cis rs7615952 0.605 rs11708269 chr3:125332150 C/T cg11143507 chr3:125485238 NA -0.7 -6.11 -0.32 2.85e-9 Blood pressure (smoking interaction); CRC cis rs35883536 0.935 rs1577510 chr1:101114295 G/A cg14515779 chr1:101123966 NA 0.38 7.03 0.36 1.21e-11 Monocyte count; CRC cis rs2346160 0.899 rs206974 chr6:167690300 G/A cg27333441 chr6:167680455 NA -0.4 -6.71 -0.35 8.78e-11 Parental extreme longevity (95 years and older); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg19354023 chr10:89577882 ATAD1;CFLP1 0.43 6.05 0.32 3.98e-9 Response to antipsychotic treatment; CRC cis rs10504229 0.728 rs77197419 chr8:58150879 C/A cg22535103 chr8:58192502 C8orf71 -0.68 -8.37 -0.42 1.72e-15 Developmental language disorder (linguistic errors); CRC cis rs3858526 0.959 rs4559671 chr11:5923419 C/T cg02574844 chr11:5959923 NA -0.44 -6.2 -0.32 1.65e-9 DNA methylation (variation); CRC cis rs3791406 0.654 rs3752804 chr2:240029490 C/T cg08444004 chr2:240086178 HDAC4 -0.32 -5.77 -0.3 1.83e-8 Skin aging (microtopography measurement); CRC cis rs12431939 0.598 rs10873047 chr14:51727239 G/T cg23942311 chr14:51606299 NA 0.51 6.77 0.35 5.91e-11 Cancer; CRC cis rs2075671 0.855 rs62483567 chr7:100286435 G/A cg20848291 chr7:100343083 ZAN -0.65 -9.81 -0.48 4.19e-20 Other erythrocyte phenotypes; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg12665724 chr11:43364829 API5 -0.39 -6.1 -0.32 2.93e-9 Liver disease severity in Alagille syndrome; CRC cis rs798554 1.000 rs798544 chr7:2763102 A/G cg21192091 chr7:2758800 NA 0.35 5.8 0.3 1.53e-8 Height; CRC cis rs2070488 1.000 rs2268758 chr3:38514049 C/T cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.9 16.31 0.67 2.93e-44 Electrocardiographic conduction measures; CRC cis rs6952808 0.635 rs12154473 chr7:1982181 A/G cg22963979 chr7:1858916 MAD1L1 0.46 7.11 0.37 7.13e-12 Bipolar disorder and schizophrenia; CRC cis rs1322512 0.917 rs2250013 chr6:153006539 A/T cg03415253 chr6:152958462 SYNE1 0.4 6.03 0.32 4.39e-9 Tonometry; CRC cis rs17767294 0.612 rs9461425 chr6:27919688 G/A cg20358437 chr6:27870759 NA 0.59 5.82 0.31 1.36e-8 Parkinson's disease; CRC trans rs877282 0.945 rs71491303 chr10:772884 G/T cg22713356 chr15:30763199 NA 1.15 14.73 0.63 4.62e-38 Uric acid levels; CRC trans rs4352210 0.963 rs4670727 chr2:37760784 G/A cg13134662 chr9:136858680 VAV2 -0.41 -5.99 -0.31 5.46e-9 RR interval (heart rate); CRC cis rs6951245 0.872 rs74360401 chr7:1067403 G/A cg04025307 chr7:1156635 C7orf50 0.63 6.63 0.34 1.41e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC trans rs929596 0.517 rs3806592 chr2:234625936 C/T cg14520829 chr3:18390388 SATB1 0.42 6.45 0.34 3.9e-10 Total bilirubin levels in HIV-1 infection; CRC cis rs5769765 0.773 rs9616395 chr22:50317803 A/G cg08270630 chr22:50330655 NA -0.45 -5.91 -0.31 8.61e-9 Schizophrenia; CRC cis rs561341 0.882 rs504887 chr17:30322881 T/A cg12193833 chr17:30244370 NA -0.67 -8.42 -0.42 1.22e-15 Hip circumference adjusted for BMI; CRC cis rs2019137 0.936 rs3828188 chr2:113954247 G/A cg12889195 chr2:113992843 PAX8;LOC440839;LOC654433 -0.5 -7.23 -0.37 3.48e-12 Lymphocyte counts; CRC cis rs13256369 0.802 rs11249885 chr8:8562008 C/T cg18904891 chr8:8559673 CLDN23 0.61 8.47 0.42 8.49e-16 Obesity-related traits; CRC cis rs8072100 0.713 rs8075058 chr17:45482857 A/G cg08085267 chr17:45401833 C17orf57 -0.58 -8.8 -0.44 7.99e-17 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs1865760 0.519 rs4360119 chr6:25815074 C/G cg16482183 chr6:26056742 HIST1H1C 0.8 10.29 0.49 1.05e-21 Height; CRC cis rs208520 0.526 rs2881644 chr6:66803535 A/C cg07460842 chr6:66804631 NA 1.16 24.42 0.8 7.15e-76 Exhaled nitric oxide output; CRC cis rs12760731 0.623 rs10913541 chr1:178347714 G/A cg00404053 chr1:178313656 RASAL2 0.74 9.33 0.46 1.56e-18 Obesity-related traits; CRC cis rs9611565 0.694 rs202616 chr22:41822221 C/G cg06634786 chr22:41940651 POLR3H 0.7 7.77 0.39 1.03e-13 Vitiligo; CRC cis rs2839186 0.900 rs2839196 chr21:47708037 G/A cg11766577 chr21:47581405 C21orf56 -0.51 -7.96 -0.4 2.75e-14 Testicular germ cell tumor; CRC cis rs7552404 1.000 rs7533888 chr1:76160449 A/C cg03433033 chr1:76189801 ACADM 0.82 11.35 0.53 1.98e-25 Blood metabolite levels;Acylcarnitine levels; CRC cis rs1215050 0.527 rs1214998 chr4:99042878 T/G cg05340658 chr4:99064831 C4orf37 0.5 7.47 0.38 7.16e-13 Waist-to-hip ratio adjusted for body mass index; CRC cis rs10046574 0.561 rs17481974 chr7:135195701 A/G cg27474649 chr7:135195673 CNOT4 0.67 6.16 0.32 2.14e-9 Peripheral arterial disease (traffic-related air pollution interaction); CRC trans rs9467711 0.606 rs9379897 chr6:26601526 T/C cg06606381 chr12:133084897 FBRSL1 -0.82 -6.37 -0.33 6.27e-10 Autism spectrum disorder or schizophrenia; CRC cis rs12142240 0.698 rs12385697 chr1:46818898 T/C cg14993813 chr1:46806288 NSUN4 -0.48 -6.15 -0.32 2.24e-9 Menopause (age at onset); CRC cis rs523522 0.962 rs10849753 chr12:120910813 C/T cg27279351 chr12:120934652 DYNLL1 0.79 11.41 0.53 1.2e-25 High light scatter reticulocyte count; CRC cis rs10504229 0.683 rs7838958 chr8:58136968 T/C cg21724239 chr8:58056113 NA 0.49 6.81 0.35 4.75e-11 Developmental language disorder (linguistic errors); CRC trans rs12744310 0.887 rs72667608 chr1:41794773 A/G cg19175123 chr10:103411746 FBXW4 0.46 6.13 0.32 2.55e-9 Cognitive ability (multi-trait analysis);Intelligence;Cognitive ability; CRC cis rs2115630 0.653 rs61394864 chr15:85170174 T/C cg09876464 chr15:85330779 ZNF592 0.39 6.51 0.34 2.89e-10 P wave terminal force; CRC cis rs3747547 0.892 rs72724200 chr9:37952144 G/A cg13774184 chr9:37916125 SHB -0.86 -5.71 -0.3 2.47e-8 Metabolite levels (Dihydroxy docosatrienoic acid); CRC trans rs12478296 1.000 rs6732595 chr2:243035338 T/C cg18288967 chr1:45987694 PRDX1 0.7 7.92 0.4 3.67e-14 Obesity-related traits; CRC cis rs6540556 0.769 rs6665715 chr1:209931353 A/C cg05527609 chr1:210001259 C1orf107 0.48 5.72 0.3 2.41e-8 Red blood cell count; CRC cis rs9549328 0.800 rs9549617 chr13:113628070 C/A cg24588162 chr13:113633484 MCF2L -0.43 -7.58 -0.39 3.57e-13 Systolic blood pressure; CRC cis rs76419734 0.510 rs2216515 chr4:106750214 C/T cg24545054 chr4:106630052 GSTCD;INTS12 -0.59 -6.93 -0.36 2.26e-11 Post bronchodilator FEV1; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg13577407 chr3:57994372 FLNB 0.41 6.73 0.35 7.59e-11 Liver disease severity in Alagille syndrome; CRC cis rs4243830 0.850 rs3761927 chr1:6601773 T/C cg05709478 chr1:6581295 PLEKHG5 -0.57 -6.75 -0.35 6.83e-11 Body mass index; CRC cis rs755249 0.567 rs1537817 chr1:39639653 A/G cg18385671 chr1:39797026 MACF1 0.4 5.73 0.3 2.31e-8 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs758324 0.891 rs652839 chr5:131281106 G/C cg06307176 chr5:131281290 NA -0.41 -6.17 -0.32 2.03e-9 Alzheimer's disease in APOE e4- carriers; CRC cis rs1577917 0.958 rs12197463 chr6:86445242 T/A cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.54 -7.34 -0.37 1.73e-12 Response to antipsychotic treatment; CRC cis rs7647973 1.000 rs6446262 chr3:49401153 T/C cg07636037 chr3:49044803 WDR6 0.64 7.44 0.38 8.68e-13 Menarche (age at onset); CRC cis rs9648716 1.000 rs62485365 chr7:140588215 T/G cg10747023 chr7:140774559 NA 0.45 5.9 0.31 9.21e-9 Type 2 diabetes; CRC trans rs561341 0.882 rs504887 chr17:30322881 T/A cg20587970 chr11:113659929 NA -1.25 -18.08 -0.71 3.05e-51 Hip circumference adjusted for BMI; CRC cis rs1008375 1.000 rs10939742 chr4:17659936 G/T cg16339924 chr4:17578868 LAP3 0.59 8.05 0.41 1.57e-14 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs7615952 0.641 rs66520539 chr3:125780374 G/A cg06494592 chr3:125709126 NA -0.56 -6.73 -0.35 7.33e-11 Blood pressure (smoking interaction); CRC cis rs9462846 0.691 rs9462853 chr6:42910666 T/C cg02353165 chr6:42928485 GNMT 0.63 9.21 0.45 4.06e-18 Blood protein levels; CRC cis rs6918586 0.658 rs198803 chr6:26135052 T/A cg18357526 chr6:26021779 HIST1H4A -0.48 -7.12 -0.37 6.67e-12 Schizophrenia; CRC cis rs2739330 0.731 rs5751792 chr22:24401542 G/A cg10150615 chr22:24372951 LOC391322 -0.51 -7.83 -0.4 6.96e-14 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs13108904 0.935 rs4246685 chr4:1279727 T/C cg00684032 chr4:1343700 KIAA1530 0.48 7.02 0.36 1.3e-11 Obesity-related traits; CRC cis rs727505 1.000 rs7806680 chr7:124433079 G/A cg23710748 chr7:124431027 NA -0.71 -12.74 -0.57 1.77e-30 Lewy body disease; CRC cis rs10504229 1.000 rs68112919 chr8:58188247 G/A cg22535103 chr8:58192502 C8orf71 -0.81 -12.22 -0.56 1.41e-28 Developmental language disorder (linguistic errors); CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg06443542 chr10:100206752 HPS1 0.4 6.37 0.33 6.51e-10 Obesity-related traits; CRC cis rs9486719 1.000 rs2472884 chr6:96863965 C/T cg06623918 chr6:96969491 KIAA0776 0.81 9.48 0.46 5.18e-19 Migraine;Coronary artery disease; CRC cis rs11581903 0.568 rs34087138 chr1:53083567 G/A cg19751897 chr1:52520827 TXNDC12;BTF3L4 0.79 6.17 0.32 1.96e-9 Joint mobility (Beighton score); CRC cis rs6840360 0.573 rs4696250 chr4:152266321 T/C cg09659197 chr4:152720779 NA 0.36 6.97 0.36 1.71e-11 Intelligence (multi-trait analysis); CRC trans rs7267979 1.000 rs6083844 chr20:25386832 C/T cg17903999 chr18:56338584 MALT1 0.43 7.1 0.36 7.75e-12 Liver enzyme levels (alkaline phosphatase); CRC cis rs10504229 1.000 rs58371676 chr8:58189382 G/A cg02290350 chr8:58132656 NA -0.42 -5.96 -0.31 6.62e-9 Developmental language disorder (linguistic errors); CRC cis rs6921919 0.515 rs1339898 chr6:28395506 C/T cg21251018 chr6:28226885 NKAPL 0.42 6.7 0.35 9.22e-11 Autism spectrum disorder or schizophrenia; CRC cis rs6681460 0.932 rs524114 chr1:67188335 C/T cg02459107 chr1:67143332 SGIP1 -0.36 -6.24 -0.33 1.31e-9 Presence of antiphospholipid antibodies; CRC cis rs4665809 0.590 rs4665321 chr2:26433801 A/C cg27170947 chr2:26402098 FAM59B -0.62 -8.04 -0.41 1.62e-14 Gut microbiome composition (summer); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg06593406 chr17:46696139 NA 0.42 6.04 0.32 4.27e-9 Intelligence (multi-trait analysis); CRC cis rs72945132 0.882 rs72949081 chr11:70219070 A/G cg14191688 chr11:70257035 CTTN 0.5 6.52 0.34 2.63e-10 Coronary artery disease; CRC cis rs6684514 1.000 rs11264467 chr1:156273061 A/G cg16558208 chr1:156270281 VHLL -0.5 -7.85 -0.4 6.03e-14 Mean corpuscular hemoglobin concentration;Glycated hemoglobin levels; CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg02709261 chr1:179051893 TOR3A -0.55 -6.58 -0.34 1.9e-10 Diisocyanate-induced asthma; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg13696566 chr3:119013055 CDGAP 0.41 6.16 0.32 2.08e-9 Intelligence (multi-trait analysis); CRC cis rs4319547 0.656 rs2173582 chr12:122824694 A/G cg05707623 chr12:122985044 ZCCHC8 -0.69 -8.4 -0.42 1.34e-15 Body mass index; CRC trans rs3942852 0.806 rs10734562 chr11:48128189 A/T cg15704280 chr7:45808275 SEPT13 0.62 7.86 0.4 5.51e-14 Acute lymphoblastic leukemia (childhood); CRC cis rs6938 0.534 rs1127796 chr15:75193004 C/T cg14664628 chr15:75095509 CSK 0.63 9.9 0.48 2.14e-20 Breast cancer; CRC cis rs1152591 0.729 rs1255988 chr14:64657684 C/A cg23250157 chr14:64679961 SYNE2 0.5 7.61 0.39 2.85e-13 Atrial fibrillation; CRC cis rs10876993 0.928 rs10877001 chr12:58083077 T/C cg15848620 chr12:58087721 OS9 0.6 8.12 0.41 9.56e-15 Celiac disease or Rheumatoid arthritis; CRC cis rs1008375 1.000 rs3933453 chr4:17636319 A/C cg02297831 chr4:17616191 MED28 0.47 6.36 0.33 6.91e-10 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs12497850 0.931 rs6791542 chr3:48787219 A/G cg20833759 chr3:49053208 WDR6;DALRD3 0.47 7.81 0.4 7.95e-14 Parkinson's disease; CRC trans rs6472235 0.837 rs6983945 chr8:66930466 G/C cg07884673 chr3:53033167 SFMBT1 -0.45 -6.03 -0.32 4.47e-9 Myopia (pathological);Plateletcrit; CRC cis rs8064299 0.967 rs3744208 chr17:72767565 A/G cg25054828 chr17:72772726 NAT9;TMEM104 0.62 10.0 0.48 9.83e-21 Monocyte count; CRC cis rs6840360 0.642 rs2709815 chr4:152363772 T/C cg09659197 chr4:152720779 NA 0.34 6.66 0.34 1.14e-10 Intelligence (multi-trait analysis); CRC cis rs6951245 0.554 rs10270249 chr7:1151886 G/T cg04025307 chr7:1156635 C7orf50 0.67 8.46 0.42 8.74e-16 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs1552244 0.554 rs13081079 chr3:10056348 A/G cg02579736 chr3:10068473 FANCD2;CIDECP 0.69 9.67 0.47 1.28e-19 Alzheimer's disease; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg04849788 chr3:160283695 KPNA4 0.54 7.01 0.36 1.37e-11 Thyroid stimulating hormone; CRC cis rs1997103 0.906 rs6593232 chr7:55402916 C/T cg17469321 chr7:55412551 NA 0.73 11.31 0.53 2.87e-25 QRS interval (sulfonylurea treatment interaction); CRC trans rs6703335 0.870 rs10803142 chr1:243598234 A/G cg19560979 chr8:11627473 NEIL2 0.45 6.33 0.33 7.9e-10 Schizophrenia;Schizophrenia, schizoaffective disorder or bipolar disorder; CRC cis rs734999 0.545 rs9970196 chr1:2574078 T/C cg18854424 chr1:2615690 NA -0.41 -7.65 -0.39 2.23e-13 Ulcerative colitis; CRC cis rs7113874 0.589 rs10840056 chr11:8498064 A/C cg17679104 chr11:8615758 STK33 0.35 5.74 0.3 2.17e-8 Body mass index in physically active individuals;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs10493773 0.609 rs12097932 chr1:86182216 A/G cg00734567 chr1:86172782 ZNHIT6 -0.49 -7.49 -0.38 6.49e-13 Urate levels in overweight individuals; CRC cis rs17345786 0.906 rs55710435 chr3:101180330 G/A cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.58 6.85 0.35 3.63e-11 Colonoscopy-negative controls vs population controls; CRC cis rs7666738 0.830 rs2865990 chr4:99067399 C/A cg17366294 chr4:99064904 C4orf37 0.44 7.38 0.38 1.32e-12 Colonoscopy-negative controls vs population controls; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg04749771 chr14:59950705 C14orf149;JKAMP 0.46 6.12 0.32 2.59e-9 Anxiety disorder; CRC cis rs9309473 1.000 rs7583255 chr2:73797996 T/G cg20560298 chr2:73613845 ALMS1 -0.47 -5.81 -0.3 1.5e-8 Metabolite levels; CRC cis rs11148252 0.574 rs73186430 chr13:53232891 T/C cg12458913 chr13:53173898 NA 0.8 14.9 0.63 1.01e-38 Lewy body disease; CRC cis rs4474465 0.850 rs4387376 chr11:78257662 T/C cg27205649 chr11:78285834 NARS2 0.51 6.6 0.34 1.67e-10 Alzheimer's disease (survival time); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg21400344 chr1:25870172 LDLRAP1 0.45 7.39 0.38 1.24e-12 Liver disease severity in Alagille syndrome; CRC cis rs728616 0.867 rs2152548 chr10:81802667 G/A cg11900509 chr10:81946545 ANXA11 -0.61 -6.46 -0.34 3.7e-10 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs7072216 0.806 rs9804285 chr10:100169472 C/T cg26618903 chr10:100175079 PYROXD2 -0.55 -9.17 -0.45 5.33e-18 Metabolite levels; CRC cis rs3924048 0.519 rs11121927 chr1:12614403 G/C cg00291366 chr1:12616550 NA 0.48 6.74 0.35 7.24e-11 Optic cup area; CRC trans rs9329221 0.710 rs11785061 chr8:10259528 G/C cg06636001 chr8:8085503 FLJ10661 0.5 7.44 0.38 8.99e-13 Neuroticism; CRC cis rs9322193 0.962 rs4869966 chr6:150084850 A/G cg07701084 chr6:150067640 NUP43 0.46 6.49 0.34 3.1e-10 Lung cancer; CRC trans rs1814175 0.791 rs10839395 chr11:49846274 G/T cg03929089 chr4:120376271 NA -0.92 -17.12 -0.69 1.97e-47 Height; CRC cis rs72615157 0.664 rs6953580 chr7:99825275 A/G cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.51 5.98 0.31 5.82e-9 Lung function (FEV1/FVC); CRC cis rs4076764 1.000 rs4469696 chr1:163424565 C/T cg24596788 chr1:163392923 NA -0.64 -10.17 -0.49 2.6e-21 Motion sickness; CRC cis rs4927850 0.881 rs7630489 chr3:195753401 T/C cg00031303 chr3:195681400 NA 0.51 7.32 0.37 1.88e-12 Pancreatic cancer; CRC cis rs7662987 0.517 rs2851260 chr4:100033574 C/T cg13256891 chr4:100009986 ADH5 0.63 8.54 0.43 4.99e-16 Smoking initiation; CRC cis rs365302 1.000 rs486468 chr6:159651205 C/T cg14500486 chr6:159655392 FNDC1 0.44 6.82 0.35 4.31e-11 Coronary heart disease; CRC cis rs2839186 0.564 rs4819215 chr21:47623573 G/A cg13012494 chr21:47604986 C21orf56 0.48 7.78 0.39 9.25e-14 Testicular germ cell tumor; CRC cis rs10504229 0.593 rs12155520 chr8:58014318 C/T cg21724239 chr8:58056113 NA 0.77 9.81 0.48 4.41e-20 Developmental language disorder (linguistic errors); CRC cis rs12956009 0.583 rs35970525 chr18:44882625 C/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.4 5.99 0.31 5.46e-9 Educational attainment (years of education); CRC cis rs10760123 1 rs10760123 chr9:123650534 T/G cg09419670 chr9:123605666 PSMD5;LOC253039 0.59 8.63 0.43 2.61e-16 Allergic disease (asthma, hay fever or eczema); CRC cis rs4481887 1.000 rs7517319 chr1:248466408 C/A cg13385794 chr1:248469461 NA 0.39 6.98 0.36 1.62e-11 Common traits (Other); CRC trans rs7267979 1.000 rs2424700 chr20:25266513 A/G cg17903999 chr18:56338584 MALT1 -0.42 -6.95 -0.36 1.94e-11 Liver enzyme levels (alkaline phosphatase); CRC cis rs8060686 0.841 rs73594554 chr16:67920049 G/A cg07125278 chr16:67683757 RLTPR -0.63 -7.24 -0.37 3.12e-12 HDL cholesterol;Metabolic syndrome; CRC cis rs6089584 0.850 rs6142939 chr20:60627729 A/G cg06108461 chr20:60628389 TAF4 -0.91 -15.67 -0.65 9.55e-42 Body mass index; CRC cis rs637571 0.522 rs493899 chr11:65747952 A/C cg26695010 chr11:65641043 EFEMP2 -0.4 -6.12 -0.32 2.59e-9 Eosinophil percentage of white cells; CRC cis rs9783347 1.000 rs4150566 chr11:18355599 C/G cg15585147 chr11:18324498 HPS5 0.43 6.08 0.32 3.29e-9 Pancreatic cancer; CRC cis rs6460942 1.000 rs62448563 chr7:12400040 G/A cg06484146 chr7:12443880 VWDE -0.76 -7.53 -0.38 4.86e-13 Coronary artery disease; CRC cis rs1552244 0.554 rs3732965 chr3:10048760 A/C cg13047869 chr3:10149882 C3orf24 0.39 5.93 0.31 7.54e-9 Alzheimer's disease; CRC cis rs9467711 0.591 rs28360595 chr6:26030044 A/G cg16898833 chr6:26189333 HIST1H4D 0.74 6.09 0.32 3.16e-9 Autism spectrum disorder or schizophrenia; CRC cis rs6735179 0.647 rs749089 chr2:1763213 T/C cg19300414 chr2:1746591 PXDN 0.35 6.21 0.32 1.63e-9 Response to antipsychotic treatment; CRC cis rs9311474 0.597 rs13303 chr3:52558008 T/C cg17372223 chr3:52568218 NT5DC2 0.4 6.03 0.32 4.38e-9 Electroencephalogram traits; CRC cis rs11308613 1 rs11308613 chr13:38558010 GT/G cg26068090 chr13:38518217 NA -0.4 -5.86 -0.31 1.1e-8 Mild influenza (H1N1) infection; CRC cis rs12900413 0.687 rs34484228 chr15:90304067 A/G cg24249390 chr15:90295951 MESP1 -0.56 -8.69 -0.43 1.71e-16 Coronary artery aneurysm in Kawasaki disease; CRC cis rs12580194 0.593 rs61957899 chr12:55731971 C/T cg23425280 chr12:56401806 NA 0.47 6.03 0.32 4.47e-9 Cancer; CRC cis rs9649213 0.574 rs9648908 chr7:97945236 C/T cg00277769 chr7:97922759 BAIAP2L1 -0.61 -10.64 -0.51 6.34e-23 Prostate cancer (SNP x SNP interaction); CRC cis rs6502050 0.835 rs3924781 chr17:80113130 T/C cg22110888 chr17:80059540 CCDC57 0.43 6.7 0.35 9.27e-11 Life satisfaction; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg10440483 chr1:23810433 ASAP3 0.45 6.09 0.32 3.11e-9 Anxiety disorder; CRC trans rs561341 1.000 rs8069199 chr17:30281845 A/G cg20587970 chr11:113659929 NA -1.18 -17.22 -0.69 7.98e-48 Hip circumference adjusted for BMI; CRC cis rs9914988 0.943 rs2874253 chr17:27157863 A/T cg20469991 chr17:27169893 C17orf63 -0.59 -7.19 -0.37 4.48e-12 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs477895 0.713 rs11600867 chr11:63972052 T/A cg04317338 chr11:64019027 PLCB3 0.63 7.58 0.39 3.48e-13 Mean platelet volume; CRC cis rs2019137 0.905 rs2276561 chr2:113956371 G/C cg21482265 chr2:113992762 PAX8;LOC440839;LOC654433 -0.46 -6.57 -0.34 1.97e-10 Lymphocyte counts; CRC cis rs501916 0.634 rs3743286 chr15:48065792 A/G cg16110827 chr15:48056943 SEMA6D -0.5 -7.46 -0.38 7.85e-13 Inflammatory bowel disease;Ulcerative colitis; CRC cis rs2197308 0.765 rs11182900 chr12:37934009 C/T cg26384229 chr12:38710491 ALG10B 0.68 8.97 0.44 2.37e-17 Morning vs. evening chronotype; CRC cis rs9341808 0.718 rs2322630 chr6:80841033 A/G cg08355045 chr6:80787529 NA 0.43 7.08 0.36 8.71e-12 Sitting height ratio; CRC cis rs77972916 0.505 rs6753197 chr2:43527962 G/T cg06169590 chr2:43455088 ZFP36L2;LOC100129726 -0.66 -7.89 -0.4 4.53e-14 Granulocyte percentage of myeloid white cells; CRC cis rs1577917 1.000 rs12201571 chr6:86609750 A/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.53 -6.61 -0.34 1.53e-10 Response to antipsychotic treatment; CRC cis rs13256369 0.802 rs12681925 chr8:8561649 G/A cg06671706 chr8:8559999 CLDN23 0.62 9.09 0.45 9.32e-18 Obesity-related traits; CRC cis rs9649213 0.593 rs55825602 chr7:98013039 T/C cg24562669 chr7:97807699 LMTK2 0.44 7.24 0.37 3.11e-12 Prostate cancer (SNP x SNP interaction); CRC cis rs6502050 0.731 rs4789730 chr17:80145983 T/A cg13198984 chr17:80129470 CCDC57 0.47 8.31 0.42 2.54e-15 Life satisfaction; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg26547359 chr10:16859530 RSU1 -0.44 -6.91 -0.36 2.46e-11 Myopia (pathological); CRC cis rs372883 0.564 rs766928 chr21:30753606 A/G cg08807101 chr21:30365312 RNF160 0.53 7.52 0.38 5.34e-13 Pancreatic cancer; CRC cis rs17443541 0.507 rs4675705 chr2:200456952 T/C cg03741458 chr2:200468445 NA -0.36 -5.69 -0.3 2.77e-8 Intelligence (multi-trait analysis); CRC cis rs2302190 0.882 rs11658998 chr17:56655786 T/G cg12560992 chr17:57184187 TRIM37 0.53 6.22 0.32 1.55e-9 Vitamin D levels; CRC cis rs7943191 0.810 rs7942154 chr11:62337163 G/A cg22862634 chr11:62369728 EML3;MTA2 0.53 8.37 0.42 1.68e-15 Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction); CRC cis rs72634501 0.716 rs4660165 chr1:39578532 C/T cg18385671 chr1:39797026 MACF1 0.43 6.01 0.31 5e-9 HDL cholesterol; CRC cis rs1129187 0.791 rs1129186 chr6:42932202 C/T cg21280719 chr6:42927975 GNMT -0.46 -10.45 -0.5 3.02e-22 Alzheimer's disease in APOE e4+ carriers; CRC cis rs6930083 0.713 rs1321308 chr6:36638691 A/C cg08179530 chr6:36648295 CDKN1A -0.71 -11.52 -0.54 5.22e-26 Coronary artery disease; CRC cis rs4664293 0.647 rs6724151 chr2:160499299 C/A cg08347373 chr2:160653686 CD302 0.39 6.68 0.35 1.03e-10 Monocyte percentage of white cells; CRC trans rs7819412 0.595 rs10106914 chr8:10987651 T/G cg06636001 chr8:8085503 FLJ10661 -0.5 -7.65 -0.39 2.24e-13 Triglycerides; CRC cis rs4862750 0.872 rs13143414 chr4:187878213 G/A cg03452623 chr4:187889614 NA -0.94 -23.56 -0.79 1.37e-72 Lobe attachment (rater-scored or self-reported); CRC cis rs6960043 0.738 rs10950548 chr7:15057728 G/A cg19272540 chr7:15055459 NA 0.23 6.18 0.32 1.84e-9 Type 2 diabetes; CRC cis rs72781680 0.898 rs17763224 chr2:24213776 T/C cg08917208 chr2:24149416 ATAD2B 0.9 9.11 0.45 8.5e-18 Lymphocyte counts; CRC cis rs1552244 0.554 rs3732965 chr3:10048760 A/C cg18598329 chr3:10140678 FANCD2;C3orf24 -0.54 -7.64 -0.39 2.32e-13 Alzheimer's disease; CRC cis rs1965732 0.958 rs6755529 chr2:3711972 C/T cg25251562 chr2:3704773 ALLC 0.43 6.48 0.34 3.41e-10 Response to inhaled corticosteroid treatment in asthma (change in FEV1); CRC cis rs9372498 0.536 rs72952761 chr6:118866758 A/C cg22561889 chr6:118971681 C6orf204 0.5 6.52 0.34 2.71e-10 Diastolic blood pressure; CRC cis rs875971 0.619 rs12533585 chr7:65984605 G/C cg05627663 chr7:65219948 SNORA22;CCT6P1 0.43 6.46 0.34 3.8e-10 Aortic root size; CRC cis rs6952808 0.582 rs11763870 chr7:2027448 T/C cg02951883 chr7:2050386 MAD1L1 0.61 10.22 0.49 1.79e-21 Bipolar disorder and schizophrenia; CRC cis rs877282 0.842 rs12357963 chr10:757562 C/T cg17470449 chr10:769945 NA 0.64 8.39 0.42 1.42e-15 Uric acid levels; CRC cis rs9420 0.961 rs12804972 chr11:57463767 T/C cg23127183 chr11:57508653 C11orf31 -0.52 -7.04 -0.36 1.12e-11 Schizophrenia; CRC cis rs853679 0.517 rs9283884 chr6:28135660 C/G cg12172441 chr6:28176163 NA -0.64 -7.52 -0.38 5.12e-13 Depression; CRC cis rs10504229 0.861 rs116923397 chr8:58185162 T/G cg22535103 chr8:58192502 C8orf71 -0.82 -12.28 -0.56 8.71e-29 Developmental language disorder (linguistic errors); CRC cis rs4853036 0.904 rs7578366 chr2:70135695 C/T cg02498382 chr2:70120550 SNRNP27 -0.45 -6.92 -0.36 2.36e-11 Colorectal or endometrial cancer; CRC cis rs262150 0.530 rs2730232 chr7:158784469 C/T cg12590608 chr7:158785262 NA -0.42 -6.58 -0.34 1.81e-10 Facial morphology (factor 20); CRC trans rs7267979 0.816 rs3746337 chr20:25208272 C/T cg17903999 chr18:56338584 MALT1 -0.42 -6.73 -0.35 7.51e-11 Liver enzyme levels (alkaline phosphatase); CRC cis rs1729951 0.575 rs1654926 chr3:136709924 G/A cg21827317 chr3:136751795 NA 0.35 5.63 0.3 3.91e-8 Neuroticism; CRC cis rs317689 0.819 rs317664 chr12:69704747 C/A cg14784868 chr12:69753453 YEATS4 0.44 5.7 0.3 2.73e-8 Response to diuretic therapy; CRC cis rs9311474 0.632 rs6445528 chr3:52572447 C/T cg10802521 chr3:52805072 NEK4 0.53 8.4 0.42 1.35e-15 Electroencephalogram traits; CRC cis rs1401999 0.966 rs2139560 chr3:183653869 A/G cg05044414 chr3:183734942 ABCC5 0.48 8.33 0.42 2.17e-15 Anterior chamber depth; CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg04628197 chr6:143771878 ADAT2;PEX3 0.38 6.01 0.31 4.94e-9 Obesity-related traits; CRC cis rs11098499 0.909 rs28632018 chr4:120386730 T/C cg09307838 chr4:120376055 NA 0.71 10.92 0.52 6.75e-24 Corneal astigmatism; CRC cis rs4478858 0.735 rs11590120 chr1:31792324 A/G cg00250761 chr1:31883323 NA -0.4 -7.41 -0.38 1.08e-12 Alcohol dependence; CRC cis rs10504229 0.683 rs67048677 chr8:58140023 C/G cg22535103 chr8:58192502 C8orf71 -0.7 -9.34 -0.46 1.47e-18 Developmental language disorder (linguistic errors); CRC trans rs35110281 0.807 rs4818850 chr21:45028071 T/G cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.43 6.92 0.36 2.37e-11 Mean corpuscular volume; CRC cis rs2760061 0.603 rs697762 chr1:228192410 G/A cg02753203 chr1:228287806 NA 0.82 12.79 0.58 1.09e-30 Diastolic blood pressure; CRC cis rs514406 0.644 rs928451 chr1:53195800 A/G cg27535305 chr1:53392650 SCP2 0.36 6.42 0.33 4.77e-10 Monocyte count; CRC cis rs4750440 0.702 rs7911259 chr10:14031051 T/C cg00551146 chr10:14014579 FRMD4A 0.36 5.74 0.3 2.11e-8 Adiponectin levels; CRC trans rs2840044 1.000 rs225243 chr17:33947212 A/G cg19694781 chr19:47549865 TMEM160 -0.46 -7.3 -0.37 2.14e-12 Response to radiotherapy in cancer (late toxicity); CRC trans rs7944735 1.000 rs7944735 chr11:47955608 G/C cg15704280 chr7:45808275 SEPT13 0.56 6.34 0.33 7.66e-10 Intraocular pressure; CRC cis rs8062405 0.755 rs62034358 chr16:28587597 G/T cg16576597 chr16:28551801 NUPR1 0.57 8.47 0.42 8.25e-16 Cognitive ability (multi-trait analysis);Cognitive ability; CRC cis rs1799949 1.000 rs2037076 chr17:41305883 G/A cg23758822 chr17:41437982 NA 0.79 13.51 0.6 2.13e-33 Menopause (age at onset); CRC cis rs7666738 0.716 rs13108535 chr4:99046324 A/G cg17366294 chr4:99064904 C4orf37 0.45 7.75 0.39 1.16e-13 Colonoscopy-negative controls vs population controls; CRC cis rs7113874 0.524 rs10769926 chr11:8623674 C/A cg17679104 chr11:8615758 STK33 0.34 5.8 0.3 1.59e-8 Body mass index in physically active individuals;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs55788414 0.932 rs12102293 chr16:81181607 T/C cg06400318 chr16:81190750 PKD1L2 -0.58 -6.7 -0.35 9.27e-11 Left ventricular obstructive tract defect (maternal effect); CRC cis rs1448094 0.872 rs10863146 chr12:86408326 C/G cg02569458 chr12:86230093 RASSF9 0.41 6.84 0.35 3.79e-11 Major depressive disorder; CRC cis rs4665809 0.590 rs34728554 chr2:26481959 C/G cg22920501 chr2:26401640 FAM59B 0.85 12.21 0.56 1.54e-28 Gut microbiome composition (summer); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg04671367 chr2:220159849 PTPRN;MIR153-1 0.44 6.27 0.33 1.13e-9 Response to antipsychotic treatment; CRC cis rs765787 0.530 rs11070445 chr15:45513163 T/A cg24006582 chr15:45444508 DUOX1 0.52 7.54 0.38 4.61e-13 Uric acid levels; CRC cis rs763014 1.000 rs763014 chr16:675680 T/C cg03804128 chr16:635623 NA 0.3 6.9 0.36 2.63e-11 Height; CRC trans rs7824557 0.806 rs7007394 chr8:11094566 G/A cg06636001 chr8:8085503 FLJ10661 -0.44 -6.01 -0.31 4.94e-9 Retinal vascular caliber; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg27294431 chr1:186344717 TPR;C1orf27;MIR548F1 0.48 6.19 0.32 1.81e-9 Thyroid stimulating hormone; CRC cis rs12900413 0.687 rs6496602 chr15:90317797 A/G cg24249390 chr15:90295951 MESP1 -0.57 -9.35 -0.46 1.36e-18 Coronary artery aneurysm in Kawasaki disease; CRC cis rs3540 0.557 rs11634314 chr15:91042066 A/C cg22089800 chr15:90895588 ZNF774 -0.57 -9.31 -0.46 1.82e-18 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; CRC cis rs9287719 0.967 rs12467642 chr2:10761484 G/A cg00105475 chr2:10696890 NA 0.45 7.27 0.37 2.63e-12 Prostate cancer; CRC cis rs13191362 1.000 rs13191362 chr6:163033350 A/G cg21926612 chr6:163149169 PACRG;PARK2 0.95 12.57 0.57 7.49e-30 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs6973256 0.569 rs6944149 chr7:133381365 A/C cg10665199 chr7:133106180 EXOC4 0.46 7.21 0.37 3.96e-12 Intelligence (multi-trait analysis); CRC cis rs8180040 1.000 rs811115 chr3:47322133 C/T cg02527881 chr3:46936655 PTH1R -0.4 -7.49 -0.38 6.52e-13 Colorectal cancer; CRC trans rs12438945 0.638 rs1915215 chr15:55199477 A/C cg18374948 chr20:62194192 PRIC285 0.45 6.31 0.33 8.86e-10 Glucose homeostasis traits; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg24482724 chr7:43878609 NA 0.36 6.07 0.32 3.52e-9 Liver disease severity in Alagille syndrome; CRC cis rs7617480 0.648 rs6806356 chr3:48727636 G/A cg07636037 chr3:49044803 WDR6 0.71 8.99 0.44 2.02e-17 Subjective well-being (multi-trait analysis);Menarche (age at onset); CRC cis rs473651 0.901 rs563282 chr2:239329736 T/C cg18131467 chr2:239335373 ASB1 0.87 15.53 0.65 3.5e-41 Multiple system atrophy; CRC cis rs910316 1.000 rs4903289 chr14:75623988 C/T cg03030879 chr14:75389066 RPS6KL1 0.45 6.83 0.35 4.12e-11 Height; CRC cis rs10504229 0.683 rs16921843 chr8:58113338 T/C cg22535103 chr8:58192502 C8orf71 -0.69 -9.23 -0.45 3.37e-18 Developmental language disorder (linguistic errors); CRC cis rs11931598 0.702 rs10937780 chr4:7048842 A/G cg26116260 chr4:7069785 GRPEL1 -0.48 -7.14 -0.37 6.14e-12 Sum basophil neutrophil counts;Sum neutrophil eosinophil counts;Granulocyte count;Neutrophil count;Myeloid white cell count; CRC cis rs11864453 0.713 rs6680 chr16:72146570 T/C cg23815491 chr16:72088622 HP 0.51 7.92 0.4 3.65e-14 Fibrinogen levels; CRC cis rs2404602 0.716 rs7164060 chr15:76707694 T/C cg23625390 chr15:77176239 SCAPER 0.47 6.92 0.36 2.32e-11 Blood metabolite levels; CRC cis rs6585424 0.929 rs12256429 chr10:81938632 A/G cg11900509 chr10:81946545 ANXA11 -0.7 -8.68 -0.43 1.83e-16 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs4862750 0.874 rs6553027 chr4:187875777 T/C cg03647317 chr4:187891568 NA -0.54 -9.88 -0.48 2.5e-20 Lobe attachment (rater-scored or self-reported); CRC cis rs8060686 0.641 rs9938553 chr16:68183064 T/A cg08314208 chr16:67682810 RLTPR -0.47 -5.66 -0.3 3.25e-8 HDL cholesterol;Metabolic syndrome; CRC cis rs1865760 1.000 rs6905887 chr6:25912103 T/C cg17691542 chr6:26056736 HIST1H1C 0.56 8.46 0.42 8.98e-16 Height; CRC trans rs61931739 0.517 rs10844802 chr12:34231001 C/A cg26384229 chr12:38710491 ALG10B 0.54 6.85 0.35 3.62e-11 Morning vs. evening chronotype; CRC trans rs951252 0.504 rs11734405 chr4:146081096 C/T cg20095338 chr12:76478402 NAP1L1 0.5 6.48 0.34 3.26e-10 Hip circumference; CRC cis rs2832077 0.527 rs1048546 chr21:30244877 G/T cg24692254 chr21:30365293 RNF160 -0.44 -6.5 -0.34 2.92e-10 Cognitive test performance; CRC cis rs10450586 0.863 rs6484285 chr11:27299127 G/A cg10370305 chr11:27303972 NA 0.38 6.23 0.32 1.42e-9 Total body bone mineral density; CRC cis rs8180040 0.764 rs6794193 chr3:47114904 T/C cg27129171 chr3:47204927 SETD2 0.69 11.18 0.52 7.93e-25 Colorectal cancer; CRC cis rs7811142 0.830 rs7792525 chr7:99972122 A/G cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.14 16.35 0.67 2.22e-44 Platelet count; CRC cis rs2760061 0.784 rs1745414 chr1:228212159 T/A cg02753203 chr1:228287806 NA 0.69 10.61 0.5 8.23e-23 Diastolic blood pressure; CRC cis rs8010715 0.848 rs8009511 chr14:24593980 G/A cg23112188 chr14:24563095 PCK2 -0.36 -7.02 -0.36 1.29e-11 IgG glycosylation; CRC cis rs7258465 0.965 rs2385088 chr19:18545540 A/G cg06462663 chr19:18546047 ISYNA1 0.49 7.08 0.36 9.04e-12 Breast cancer; CRC cis rs9322193 0.923 rs9383812 chr6:150033491 C/T cg07701084 chr6:150067640 NUP43 0.61 9.12 0.45 7.81e-18 Lung cancer; CRC trans rs7615952 0.512 rs4234285 chr3:125404477 G/A cg07211511 chr3:129823064 LOC729375 -0.61 -8.55 -0.43 4.86e-16 Blood pressure (smoking interaction); CRC cis rs17376456 0.877 rs55832164 chr5:93436579 C/T cg25358565 chr5:93447407 FAM172A 1.02 10.46 0.5 2.75e-22 Diabetic retinopathy; CRC cis rs7945705 0.902 rs11042088 chr11:8843515 T/A cg12365402 chr11:9010492 NRIP3 0.43 6.7 0.35 9.32e-11 Hemoglobin concentration; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg06906980 chr8:86157935 CA13 0.37 6.19 0.32 1.83e-9 Liver disease severity in Alagille syndrome; CRC cis rs13108904 0.935 rs1732102 chr4:1277924 T/C cg00684032 chr4:1343700 KIAA1530 -0.37 -5.62 -0.3 4e-8 Obesity-related traits; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg13604008 chr9:135906154 GTF3C5 0.39 6.05 0.32 3.99e-9 Liver disease severity in Alagille syndrome; CRC trans rs4650994 0.525 rs11806608 chr1:178511375 T/C cg05059571 chr16:84539110 KIAA1609 -0.66 -9.43 -0.46 7.56e-19 HDL cholesterol levels;HDL cholesterol; CRC cis rs1997103 0.954 rs1997099 chr7:55405540 T/C cg17469321 chr7:55412551 NA 0.72 11.3 0.53 3.17e-25 QRS interval (sulfonylurea treatment interaction); CRC cis rs2455601 0.882 rs11042106 chr11:8896083 C/T cg09997546 chr11:8931473 C11orf17;ST5 0.51 6.86 0.35 3.52e-11 Schizophrenia; CRC cis rs208520 0.690 rs9345764 chr6:66820597 C/T cg07460842 chr6:66804631 NA -1.09 -15.21 -0.64 6e-40 Exhaled nitric oxide output; CRC cis rs4862750 0.914 rs1863405 chr4:187874528 G/T cg27532560 chr4:187881888 NA 0.55 10.16 0.49 2.85e-21 Lobe attachment (rater-scored or self-reported); CRC cis rs1018836 0.884 rs7008765 chr8:91632589 C/T cg16814680 chr8:91681699 NA -0.75 -11.78 -0.54 5.8e-27 Ejection fraction in Tripanosoma cruzi seropositivity; CRC cis rs79057730 0.599 rs4720893 chr7:804434 G/A cg06242242 chr7:766104 PRKAR1B;HEATR2 0.66 6.33 0.33 8.06e-10 Initial pursuit acceleration; CRC cis rs929354 0.772 rs1182444 chr7:157024510 A/G cg05182265 chr7:156933206 UBE3C 0.76 14.55 0.63 2.18e-37 Body mass index; CRC cis rs12497850 0.897 rs9850134 chr3:48957147 A/G cg20833759 chr3:49053208 WDR6;DALRD3 0.53 9.22 0.45 3.67e-18 Parkinson's disease; CRC cis rs4563143 0.663 rs5025682 chr19:29238670 A/C cg12667521 chr19:29218732 NA 0.52 8.06 0.41 1.39e-14 Methadone dose in opioid dependence; CRC cis rs2243480 0.708 rs13242216 chr7:65898277 T/C cg25985355 chr7:65971099 NA -0.53 -6.01 -0.31 4.82e-9 Diabetic kidney disease; CRC cis rs7659604 0.702 rs58649165 chr4:122693752 C/A cg19748678 chr4:122722346 EXOSC9 0.69 11.0 0.52 3.53e-24 Type 2 diabetes; CRC cis rs4555082 0.834 rs1473672 chr14:105721981 G/T cg13114125 chr14:105738426 BRF1 -0.81 -11.77 -0.54 6.28e-27 Mean platelet volume;Platelet distribution width; CRC cis rs66569888 0.523 rs4522599 chr2:106926004 G/C cg15412446 chr2:106886593 NA 0.58 8.42 0.42 1.19e-15 Facial morphology (factor 23); CRC cis rs17376456 0.877 rs13185660 chr5:93336500 G/A cg21475434 chr5:93447410 FAM172A 0.79 7.9 0.4 4.24e-14 Diabetic retinopathy; CRC cis rs1670533 1.000 rs3816474 chr4:1050653 G/A cg27284194 chr4:1044797 NA 0.52 5.96 0.31 6.48e-9 Recombination rate (females); CRC cis rs12479064 0.694 rs11896520 chr2:99995517 C/T cg26064155 chr2:99771622 LIPT1;TSGA10 -0.62 -7.33 -0.37 1.8e-12 Chronic sinus infection; CRC cis rs7584330 0.554 rs74449293 chr2:238426458 G/A cg08992911 chr2:238395768 MLPH 0.47 5.76 0.3 1.89e-8 Prostate cancer; CRC cis rs4713118 0.699 rs573179 chr6:27849676 C/A cg15845792 chr6:28175446 NA 0.78 10.29 0.49 1.02e-21 Parkinson's disease; CRC cis rs9611565 0.802 rs73176694 chr22:41786788 C/T cg06634786 chr22:41940651 POLR3H -0.66 -7.69 -0.39 1.7e-13 Vitiligo; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg21501234 chr15:64683155 TRIP4 0.49 7.58 0.39 3.58e-13 Liver disease severity in Alagille syndrome; CRC cis rs7927592 0.913 rs7118897 chr11:68360680 G/A cg16797656 chr11:68205561 LRP5 0.39 6.26 0.33 1.18e-9 Total body bone mineral density; CRC cis rs977987 0.585 rs62059845 chr16:75430713 A/G cg03315344 chr16:75512273 CHST6 0.54 9.16 0.45 5.87e-18 Dupuytren's disease; CRC cis rs1448094 0.791 rs7303256 chr12:86333217 C/T cg02569458 chr12:86230093 RASSF9 -0.45 -7.67 -0.39 1.98e-13 Major depressive disorder; CRC cis rs853679 0.517 rs9380055 chr6:28081629 A/G cg21251018 chr6:28226885 NKAPL 0.48 6.19 0.32 1.84e-9 Depression; CRC cis rs7772486 0.754 rs702318 chr6:146005873 G/T cg13319975 chr6:146136371 FBXO30 0.46 6.73 0.35 7.56e-11 Lobe attachment (rater-scored or self-reported); CRC cis rs3018066 0.831 rs6842919 chr4:106958170 A/G cg01869342 chr4:106983673 TBCK 0.42 6.43 0.33 4.55e-10 Cancer; CRC cis rs2108622 0.785 rs3093199 chr19:15989871 T/A cg13772218 chr19:15982569 NA 0.48 6.8 0.35 4.99e-11 Circulating phylloquinone levels;Vitamin E levels;Acenocoumarol maintenance dosage;Response to Vitamin E supplementation;Metabolite levels;Warfarin maintenance dose; CRC trans rs951252 0.504 rs11734405 chr4:146081096 C/T cg12205742 chr18:68097929 NA -0.51 -6.58 -0.34 1.9e-10 Hip circumference; CRC trans rs4591358 0.638 rs6732435 chr2:196406225 C/A cg12742475 chr15:75233485 NA 0.31 6.1 0.32 2.99e-9 Adverse response to chemotherapy (neutropenia/leucopenia) (all antimicrotubule drugs); CRC cis rs2153535 0.580 rs6910742 chr6:8448328 G/A cg07606381 chr6:8435919 SLC35B3 0.67 10.79 0.51 1.94e-23 Motion sickness; CRC cis rs853679 0.567 rs7740429 chr6:28399246 G/A cg21251018 chr6:28226885 NKAPL 0.42 6.06 0.32 3.79e-9 Depression; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg08210568 chr3:15141216 ZFYVE20 0.46 6.36 0.33 6.66e-10 Thyroid stimulating hormone; CRC cis rs6840360 1.000 rs1105536 chr4:152605027 C/T cg09659197 chr4:152720779 NA 0.47 9.97 0.48 1.24e-20 Intelligence (multi-trait analysis); CRC cis rs875971 0.793 rs460678 chr7:65527200 C/G cg18912574 chr7:65842487 NCRNA00174 0.39 6.7 0.35 9.19e-11 Aortic root size; CRC trans rs9650657 0.644 rs4395858 chr8:10521021 C/T cg06636001 chr8:8085503 FLJ10661 0.44 6.46 0.34 3.83e-10 Neuroticism; CRC trans rs7615952 0.546 rs11711150 chr3:125315663 C/T cg00769240 chr8:12517080 NA -0.66 -7.22 -0.37 3.65e-12 Blood pressure (smoking interaction); CRC cis rs2929278 0.561 rs62018952 chr15:44080737 T/C cg02155558 chr15:43621948 ADAL;LCMT2 -0.42 -5.69 -0.3 2.81e-8 Schizophrenia; CRC cis rs6570726 0.846 rs6899900 chr6:145883873 T/G cg05347473 chr6:146136440 FBXO30 0.37 5.73 0.3 2.3e-8 Lobe attachment (rater-scored or self-reported); CRC cis rs13191362 1.000 rs67094146 chr6:163145412 G/C cg23758597 chr6:163146217 PARK2 -0.55 -6.14 -0.32 2.33e-9 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC trans rs2303319 0.504 rs1023835 chr2:162593973 A/G cg27342122 chr8:133787442 PHF20L1 -0.72 -6.12 -0.32 2.68e-9 Cognitive function; CRC trans rs7144011 0.654 rs4903847 chr14:79854832 A/G cg13986881 chr7:73669141 RFC2 -0.49 -7.18 -0.37 4.65e-12 Waist circumference;Hip circumference; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg11263705 chr1:181059175 IER5 0.43 5.98 0.31 5.92e-9 Response to antipsychotic treatment; CRC trans rs1455244 0.700 rs7229302 chr18:11508904 G/T cg04616222 chr10:99078965 FRAT1 0.39 6.06 0.32 3.79e-9 Schizophrenia; CRC cis rs2108225 0.837 rs6959729 chr7:107446180 A/C cg18560240 chr7:107437656 SLC26A3 -0.66 -10.24 -0.49 1.52e-21 Ulcerative colitis; CRC cis rs6952808 0.624 rs60137119 chr7:2083664 A/G cg04267008 chr7:1944627 MAD1L1 -0.77 -10.67 -0.51 4.9e-23 Bipolar disorder and schizophrenia; CRC cis rs7945718 0.934 rs10831909 chr11:12817182 C/G cg25843174 chr11:12811716 TEAD1 0.51 9.37 0.46 1.15e-18 Educational attainment (years of education); CRC cis rs10504229 0.911 rs77203035 chr8:58175458 C/A cg24829409 chr8:58192753 C8orf71 -0.68 -11.34 -0.53 2.27e-25 Developmental language disorder (linguistic errors); CRC cis rs12612619 0.704 rs7602823 chr2:27309406 G/A cg00617064 chr2:27272375 NA 0.41 6.72 0.35 7.84e-11 Venous thromboembolism adjusted for sickle cell variant rs77121243-T; CRC cis rs9309711 0.623 rs4641971 chr2:3481857 A/C cg15506890 chr2:3487001 NA 0.51 8.04 0.41 1.66e-14 Neurofibrillary tangles; CRC cis rs9311474 0.508 rs6786919 chr3:52599789 A/G cg08222913 chr3:52553049 STAB1 -0.34 -6.45 -0.34 4e-10 Electroencephalogram traits; CRC cis rs11649653 0.502 rs62057232 chr16:30820866 T/C cg02466173 chr16:30829666 NA 0.54 7.51 0.38 5.75e-13 Triglycerides; CRC cis rs10489202 0.608 rs3753934 chr1:168074677 C/T cg24449463 chr1:168025552 DCAF6 -0.51 -7.21 -0.37 3.87e-12 Schizophrenia; CRC cis rs7072216 0.922 rs7097824 chr10:100151799 A/T cg26618903 chr10:100175079 PYROXD2 -0.37 -6.25 -0.33 1.29e-9 Metabolite levels; CRC cis rs6570726 0.818 rs412350 chr6:145852409 T/C cg23711669 chr6:146136114 FBXO30 0.73 12.84 0.58 7.06e-31 Lobe attachment (rater-scored or self-reported); CRC cis rs2180341 0.618 rs11154396 chr6:127638911 C/T cg24812749 chr6:127587940 RNF146 0.64 9.64 0.47 1.56e-19 Breast cancer; CRC cis rs72781680 0.784 rs72798406 chr2:24180144 T/C cg08917208 chr2:24149416 ATAD2B 0.57 6.82 0.35 4.39e-11 Lymphocyte counts; CRC cis rs35306767 0.855 rs61830900 chr10:871481 C/G cg20503657 chr10:835505 NA 1.22 15.02 0.64 3.51e-39 Eosinophil percentage of granulocytes; CRC cis rs9916302 0.904 rs801426 chr17:37441109 C/T cg07936489 chr17:37558343 FBXL20 0.8 12.23 0.56 1.37e-28 Glomerular filtration rate (creatinine); CRC cis rs6546550 0.901 rs12232914 chr2:70117176 C/T cg02498382 chr2:70120550 SNRNP27 -0.55 -9.35 -0.46 1.38e-18 Prevalent atrial fibrillation; CRC cis rs6499255 1.000 rs4078387 chr16:69814047 G/A cg15192750 chr16:69999425 NA 0.57 7.37 0.38 1.39e-12 IgE levels; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg09614276 chr2:28975489 PPP1CB 0.42 6.07 0.32 3.62e-9 Intelligence (multi-trait analysis); CRC cis rs1707322 0.752 rs11211171 chr1:46168642 A/G cg03146154 chr1:46216737 IPP 0.67 9.73 0.47 7.77e-20 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs1129187 0.755 rs9471986 chr6:42944127 A/G cg27588902 chr6:42928151 GNMT -0.4 -7.21 -0.37 3.87e-12 Alzheimer's disease in APOE e4+ carriers; CRC cis rs9814567 1.000 rs4498009 chr3:134198008 C/G cg06109529 chr3:134205091 CEP63;ANAPC13 -0.84 -12.4 -0.56 3.09e-29 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs6582630 0.623 rs12299293 chr12:38436288 G/A cg13010199 chr12:38710504 ALG10B -0.4 -5.68 -0.3 3.02e-8 Drug-induced liver injury (flucloxacillin); CRC cis rs11764590 0.585 rs11772463 chr7:2078132 A/C cg23378565 chr7:2036160 MAD1L1 -0.43 -5.88 -0.31 1.02e-8 Neuroticism; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg13720744 chr22:21271392 CRKL 0.43 6.15 0.32 2.29e-9 Intelligence (multi-trait analysis); CRC cis rs9393777 0.920 rs13195040 chr6:27413924 C/T cg26958806 chr6:27640298 NA -0.83 -5.69 -0.3 2.75e-8 Intelligence (multi-trait analysis); CRC cis rs8060686 0.545 rs8057119 chr16:68268836 C/T cg26727032 chr16:67993705 SLC12A4 -0.65 -8.23 -0.41 4.45e-15 HDL cholesterol;Metabolic syndrome; CRC cis rs6952808 0.636 rs73048162 chr7:1949328 T/C cg14004847 chr7:1930337 MAD1L1 -0.4 -5.75 -0.3 2.05e-8 Bipolar disorder and schizophrenia; CRC cis rs7618501 0.521 rs11709573 chr3:49956628 C/T cg24110177 chr3:50126178 RBM5 -0.55 -8.12 -0.41 9.62e-15 Intelligence (multi-trait analysis); CRC cis rs75422866 0.867 rs73104103 chr12:48063387 A/G cg14736327 chr12:48174669 SLC48A1 -0.79 -6.03 -0.32 4.46e-9 Pneumonia; CRC trans rs10504390 0.656 rs74776773 chr8:66544150 G/A cg26403416 chr21:43771339 TFF2 0.6 6.14 0.32 2.38e-9 IgG glycosylation; CRC cis rs478304 0.654 rs10896029 chr11:65452952 C/T cg27068330 chr11:65405492 SIPA1 -0.66 -9.8 -0.48 4.69e-20 Acne (severe); CRC cis rs2249625 0.584 rs2463744 chr6:72875936 C/T cg18830697 chr6:72922368 RIMS1 -0.39 -7.92 -0.4 3.81e-14 Acute urticaria and angioedema (non-steroidal anti-inflammatory drug-induced); CRC cis rs9894429 0.546 rs55917554 chr17:79608776 T/C cg18240062 chr17:79603768 NPLOC4 0.56 9.44 0.46 6.94e-19 Eye color traits; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg23142935 chr16:22385308 CDR2 0.46 6.64 0.34 1.3100000000000001e-10 Response to antipsychotic treatment; CRC cis rs9611565 0.512 rs768414 chr22:42135751 T/C cg06634786 chr22:41940651 POLR3H 0.68 7.6 0.39 3.04e-13 Vitiligo; CRC cis rs4654899 0.680 rs6692553 chr1:21221497 C/T cg02927042 chr1:21476669 EIF4G3 0.37 5.73 0.3 2.27e-8 Superior frontal gyrus grey matter volume; CRC cis rs1062746 0.502 rs11649601 chr16:87339220 G/C cg02258303 chr16:87377426 FBXO31 -0.56 -8.22 -0.41 4.78e-15 Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 2 peripheral neuropathy); CRC cis rs2839186 0.739 rs2280958 chr21:47642016 C/T cg05896524 chr21:47604654 C21orf56 0.47 7.15 0.37 5.74e-12 Testicular germ cell tumor; CRC cis rs6762 0.748 rs7929032 chr11:839078 G/A cg07691484 chr11:842764 TSPAN4;POLR2L -0.56 -8.27 -0.41 3.44e-15 Mean platelet volume; CRC cis rs2243480 0.803 rs36004293 chr7:65416512 T/C cg12463550 chr7:65579703 CRCP 0.63 5.98 0.31 5.8e-9 Diabetic kidney disease; CRC cis rs73200209 0.912 rs61935854 chr12:116655496 T/C cg01776926 chr12:116560359 MED13L -0.48 -5.78 -0.3 1.72e-8 Total body bone mineral density; CRC cis rs1129187 0.902 rs10948059 chr6:42928461 C/T cg09436375 chr6:42928200 GNMT -0.3 -5.63 -0.3 3.92e-8 Alzheimer's disease in APOE e4+ carriers; CRC cis rs3617 0.573 rs13072537 chr3:52896032 C/A cg15147215 chr3:52552868 STAB1 -0.46 -7.53 -0.38 4.9e-13 Red blood cell count;Autism spectrum disorder or schizophrenia; CRC cis rs597539 0.652 rs482172 chr11:68668437 C/A cg21963583 chr11:68658836 MRPL21 0.63 11.64 0.54 1.89e-26 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs6495367 1.000 rs1007366 chr15:79379541 G/A cg17916960 chr15:79447300 NA 0.37 6.05 0.32 3.88e-9 Spherical equivalent (joint analysis main effects and education interaction); CRC cis rs1506636 1.000 rs10225428 chr7:123357646 A/G cg03229431 chr7:123269106 ASB15 -0.75 -12.27 -0.56 9.78e-29 Plateletcrit;Platelet count; CRC cis rs60871478 0.786 rs55899111 chr7:827843 C/G cg13844804 chr7:814759 HEATR2 -0.68 -7.88 -0.4 4.93e-14 Cerebrospinal P-tau181p levels; CRC cis rs6840360 1.000 rs1355413 chr4:152633667 C/T cg09659197 chr4:152720779 NA 0.52 11.47 0.53 7.73e-26 Intelligence (multi-trait analysis); CRC trans rs10504390 0.585 rs118053995 chr8:66554766 G/A cg26403416 chr21:43771339 TFF2 0.59 6.13 0.32 2.49e-9 IgG glycosylation; CRC trans rs1005277 0.505 rs10827836 chr10:38215441 A/G cg17830980 chr10:43048298 ZNF37B 0.4 6.14 0.32 2.38e-9 Extrinsic epigenetic age acceleration; CRC cis rs9467773 1.000 rs6456733 chr6:26566804 C/T cg09904177 chr6:26538194 HMGN4 0.86 14.82 0.63 2.06e-38 Intelligence (multi-trait analysis); CRC cis rs1862618 0.853 rs832569 chr5:56154584 T/A cg03609598 chr5:56110824 MAP3K1 -0.83 -9.93 -0.48 1.68e-20 Initial pursuit acceleration; CRC cis rs1799949 0.965 rs34633610 chr17:41419385 A/G cg23758822 chr17:41437982 NA 0.81 13.63 0.6 7.36e-34 Menopause (age at onset); CRC cis rs3751196 0.908 rs78660952 chr12:104214990 A/T cg02344784 chr12:104178138 NT5DC3 0.7 8.24 0.41 4.16e-15 Sense of smell; CRC cis rs6732160 0.588 rs13407363 chr2:73372558 T/C cg01422370 chr2:73384389 NA 0.38 6.03 0.32 4.35e-9 Intelligence (multi-trait analysis); CRC cis rs875971 1.000 rs1182882 chr7:65562063 C/T cg12463550 chr7:65579703 CRCP -0.49 -7.05 -0.36 1.08e-11 Aortic root size; CRC cis rs751728 1.000 rs755496 chr6:33734376 C/G cg25922239 chr6:33757077 LEMD2 0.59 8.47 0.42 8.46e-16 Crohn's disease; CRC cis rs8064299 0.967 rs880827 chr17:72767435 C/T cg21922841 chr17:72744131 SLC9A3R1 -0.28 -6.03 -0.32 4.5e-9 Monocyte count; CRC cis rs736801 0.808 rs4705950 chr5:131793286 C/T cg21138405 chr5:131827807 IRF1 -0.36 -6.24 -0.33 1.33e-9 Breast cancer;Mosquito bite size; CRC trans rs10435719 0.902 rs12681142 chr8:11802601 T/C cg08975724 chr8:8085496 FLJ10661 0.39 6.07 0.32 3.55e-9 C-reactive protein levels or triglyceride levels (pleiotropy); CRC cis rs7615952 0.599 rs2279821 chr3:125734308 G/A cg04553112 chr3:125709451 NA -0.52 -5.84 -0.31 1.24e-8 Blood pressure (smoking interaction); CRC trans rs7615952 0.512 rs4679430 chr3:125357893 T/C cg00769240 chr8:12517080 NA -0.74 -10.23 -0.49 1.64e-21 Blood pressure (smoking interaction); CRC cis rs1799949 1.000 rs2037076 chr17:41305883 G/A cg05368731 chr17:41323189 NBR1 0.69 10.5 0.5 1.97e-22 Menopause (age at onset); CRC cis rs2739330 0.753 rs4822452 chr22:24254363 C/T cg10819733 chr22:24237672 NA -0.35 -6.0 -0.31 5.14e-9 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs2180341 1.000 rs3798853 chr6:127636823 C/T cg24812749 chr6:127587940 RNF146 -0.94 -13.45 -0.6 3.66e-33 Breast cancer; CRC cis rs9733 0.596 rs72702585 chr1:150696427 G/A cg15448220 chr1:150897856 SETDB1 0.45 6.41 0.33 5.09e-10 Tonsillectomy; CRC cis rs9522267 0.535 rs9522302 chr13:112236874 C/T cg14352298 chr13:112236639 NA 0.29 6.59 0.34 1.74e-10 Hepatitis; CRC cis rs875971 1.000 rs55962648 chr7:65625751 C/G cg12463550 chr7:65579703 CRCP -0.48 -6.97 -0.36 1.7e-11 Aortic root size; CRC cis rs28386778 0.863 rs1376110 chr17:61779927 A/C cg22520471 chr17:61851767 DDX42;CCDC47 0.71 10.48 0.5 2.37e-22 Prudent dietary pattern; CRC cis rs12701220 0.901 rs12701710 chr7:1090396 A/G cg02733842 chr7:1102375 C7orf50 0.66 8.48 0.42 7.48e-16 Bronchopulmonary dysplasia; CRC trans rs9825823 0.617 rs2083264 chr3:61074229 A/G cg26460816 chr5:65892187 MAST4 0.34 6.0 0.31 5.21e-9 Depressive symptom measurement or major depressive disorder; CRC cis rs7945705 0.520 rs1984791 chr11:9035027 C/T cg21881798 chr11:8931708 C11orf17;ST5 0.57 7.83 0.4 6.71e-14 Hemoglobin concentration; CRC cis rs2011503 0.843 rs2860494 chr19:19470426 T/C cg11584989 chr19:19387371 SF4 -0.49 -6.06 -0.32 3.78e-9 Bipolar disorder; CRC cis rs12586317 0.511 rs113770696 chr14:35444383 C/T cg16230307 chr14:35515116 FAM177A1 0.88 10.19 0.49 2.18e-21 Psoriasis; CRC cis rs7762018 0.891 rs3088346 chr6:170149793 T/C cg24289452 chr6:170231220 NA -0.54 -6.01 -0.31 5.05e-9 Thiazide-induced adverse metabolic effects in hypertensive patients; CRC cis rs62064224 0.589 rs9904964 chr17:30662832 A/G cg12855166 chr17:30846586 MYO1D 0.36 5.82 0.31 1.42e-8 Schizophrenia; CRC cis rs7772486 0.790 rs9403749 chr6:146162239 A/G cg13319975 chr6:146136371 FBXO30 -0.47 -7.08 -0.36 8.98e-12 Lobe attachment (rater-scored or self-reported); CRC trans rs12599106 0.754 rs11640596 chr16:34347277 T/C cg21548813 chr6:291882 DUSP22 -0.53 -7.33 -0.37 1.83e-12 Menopause (age at onset); CRC cis rs10189230 0.935 rs1864461 chr2:222347615 A/G cg14652038 chr2:222343519 EPHA4 0.55 10.4 0.5 4.28e-22 Urate levels in lean individuals; CRC cis rs1448094 0.520 rs12304244 chr12:86272823 C/T cg02569458 chr12:86230093 RASSF9 0.44 7.31 0.37 2.08e-12 Major depressive disorder; CRC cis rs1799949 1.000 rs12950607 chr17:41299928 G/C cg19454999 chr17:41278357 BRCA1;NBR2 0.55 8.65 0.43 2.28e-16 Menopause (age at onset); CRC cis rs60871478 0.898 rs62432897 chr7:825429 A/G cg05535760 chr7:792225 HEATR2 0.99 12.83 0.58 8.12e-31 Cerebrospinal P-tau181p levels; CRC cis rs4481887 0.927 rs10788765 chr1:248445642 A/G cg00666640 chr1:248458726 OR2T12 -0.54 -9.69 -0.47 1.06e-19 Common traits (Other); CRC cis rs9660992 0.710 rs4951184 chr1:205240659 A/T cg21643547 chr1:205240462 TMCC2 -0.44 -7.13 -0.37 6.29e-12 Mean corpuscular volume;Mean platelet volume; CRC cis rs172166 0.611 rs203882 chr6:28078502 G/A cg21251018 chr6:28226885 NKAPL 0.47 7.07 0.36 9.43e-12 Cardiac Troponin-T levels; CRC cis rs7677751 0.848 rs7673625 chr4:55088586 C/T cg17187183 chr4:55093834 PDGFRA 0.52 7.41 0.38 1.07e-12 Corneal astigmatism; CRC cis rs897984 0.537 rs8045637 chr16:30818662 C/T cg00531865 chr16:30841666 NA -0.51 -7.52 -0.38 5.23e-13 Dementia with Lewy bodies; CRC cis rs2228479 0.850 rs62052711 chr16:89855100 C/A cg06558623 chr16:89946397 TCF25 1.15 10.53 0.5 1.51e-22 Skin colour saturation; CRC cis rs72781680 1.000 rs56339200 chr2:24188194 C/A cg08917208 chr2:24149416 ATAD2B 0.91 9.28 0.46 2.29e-18 Lymphocyte counts; CRC cis rs7615952 0.534 rs1503072 chr3:125754691 C/T cg02807482 chr3:125708958 NA -0.45 -5.65 -0.3 3.39e-8 Blood pressure (smoking interaction); CRC cis rs4713118 0.955 rs9380012 chr6:27684654 A/G cg25164649 chr6:28176230 NA 0.54 7.3 0.37 2.13e-12 Parkinson's disease; CRC cis rs7927771 0.832 rs67116452 chr11:47385194 G/A cg18512352 chr11:47633146 NA -0.36 -7.0 -0.36 1.42e-11 Subjective well-being; CRC cis rs9921222 0.502 rs28461430 chr16:369562 G/A cg12437481 chr16:420112 MRPL28 -0.64 -8.23 -0.41 4.31e-15 Bone mineral density (spine);Bone mineral density; CRC cis rs17384381 0.953 rs2284797 chr1:85792383 C/T cg16011679 chr1:85725395 C1orf52 0.64 6.49 0.34 3.15e-10 Lobe attachment (rater-scored or self-reported); CRC cis rs4757319 0.515 rs10832402 chr11:15334036 C/T cg03245590 chr11:15329459 NA -0.55 -9.85 -0.48 3.03e-20 Breast cancer; CRC cis rs67311347 1.000 rs73076035 chr3:40439881 G/C cg09455208 chr3:40491958 NA 0.47 8.74 0.43 1.25e-16 Renal cell carcinoma; CRC cis rs9467711 0.722 rs35825164 chr6:26117404 T/C cg19084075 chr6:26124329 HIST1H2AC;HIST1H2BC 0.68 5.6 0.3 4.45e-8 Autism spectrum disorder or schizophrenia; CRC cis rs9649213 0.555 rs7785612 chr7:97933867 T/A cg21770322 chr7:97807741 LMTK2 0.54 8.87 0.44 4.84e-17 Prostate cancer (SNP x SNP interaction); CRC trans rs561341 0.830 rs2301765 chr17:30202056 T/A cg20587970 chr11:113659929 NA 0.92 11.23 0.53 5.4e-25 Hip circumference adjusted for BMI; CRC cis rs3791556 0.504 rs1001285 chr2:240107814 A/G cg27074582 chr2:240114406 HDAC4 0.4 5.75 0.3 2.05e-8 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs4481887 0.962 rs6686911 chr1:248476969 T/C cg13385794 chr1:248469461 NA 0.4 6.8 0.35 4.87e-11 Common traits (Other); CRC cis rs4665809 0.590 rs13387855 chr2:26420708 T/G cg08067268 chr2:26466485 HADHB;HADHA -0.66 -8.45 -0.42 9.58e-16 Gut microbiome composition (summer); CRC cis rs4713118 0.629 rs203888 chr6:28021589 C/T cg18032046 chr6:28092343 ZSCAN16 -0.43 -5.64 -0.3 3.68e-8 Parkinson's disease; CRC cis rs17152411 0.843 rs7904691 chr10:126582927 G/T cg07906193 chr10:126599966 NA 0.55 6.17 0.32 1.95e-9 Height; CRC cis rs4975709 0.589 rs1684967 chr5:1863055 G/C cg12288994 chr5:1860383 NA 0.38 6.82 0.35 4.39e-11 Cardiovascular disease risk factors; CRC cis rs2576037 0.526 rs2156050 chr18:44455873 A/G cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.65 -10.67 -0.51 4.9e-23 Personality dimensions; CRC cis rs9522267 0.708 rs914032 chr13:112241019 G/A cg10483660 chr13:112241077 NA 0.39 7.01 0.36 1.34e-11 Hepatitis; CRC cis rs3862030 0.720 rs3740414 chr10:104232809 T/G cg11453585 chr10:104263688 ACTR1A;SUFU -0.76 -13.31 -0.59 1.26e-32 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for body mass index; CRC cis rs4862750 0.872 rs4862747 chr4:187877236 A/T cg27532560 chr4:187881888 NA 0.54 10.05 0.48 6.48e-21 Lobe attachment (rater-scored or self-reported); CRC cis rs9747347 1 rs9747347 chr17:79606820 T/C cg18240062 chr17:79603768 NPLOC4 0.55 8.36 0.42 1.77e-15 Myopia; CRC cis rs10540 1.000 rs61876340 chr11:495699 A/C cg15790184 chr11:494944 RNH1 0.6 6.18 0.32 1.85e-9 Body mass index; CRC cis rs9311676 0.656 rs11130636 chr3:58380098 C/A cg06643156 chr3:58380774 PXK 0.41 6.33 0.33 7.82e-10 Systemic lupus erythematosus; CRC cis rs7215564 0.908 rs59252837 chr17:78717155 A/G cg09596252 chr17:78655493 RPTOR 0.58 6.25 0.33 1.28e-9 Myopia (pathological); CRC cis rs6570726 0.791 rs387376 chr6:145822565 T/C cg05347473 chr6:146136440 FBXO30 0.4 6.23 0.32 1.45e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs8062405 0.754 rs62034323 chr16:28536473 C/T cg05139728 chr16:28306816 SBK1 -0.33 -5.63 -0.3 3.77e-8 Cognitive ability (multi-trait analysis);Cognitive ability; CRC cis rs10870270 0.956 rs4880405 chr10:133787021 G/A cg08754478 chr10:133766260 PPP2R2D -0.65 -9.1 -0.45 9.06e-18 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; CRC cis rs7772486 0.686 rs6933161 chr6:146081369 G/A cg23711669 chr6:146136114 FBXO30 -0.66 -11.09 -0.52 1.77e-24 Lobe attachment (rater-scored or self-reported); CRC trans rs11148252 0.716 rs3803262 chr13:53036398 A/G cg18335740 chr13:41363409 SLC25A15 0.55 8.48 0.42 8e-16 Lewy body disease; CRC trans rs916888 0.610 rs199446 chr17:44813169 G/A cg22968622 chr17:43663579 NA -0.84 -11.65 -0.54 1.72e-26 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs6502050 0.871 rs62079998 chr17:80077245 A/C cg09264619 chr17:80180166 NA 0.38 6.28 0.33 1.08e-9 Life satisfaction; CRC cis rs12802200 0.535 rs12282299 chr11:570009 T/C cg01842473 chr11:617407 IRF7;MUPCDH -0.48 -6.2 -0.32 1.71e-9 Systemic lupus erythematosus; CRC cis rs2760061 0.819 rs708114 chr1:228197496 G/A cg02753203 chr1:228287806 NA 0.69 10.74 0.51 2.99e-23 Diastolic blood pressure; CRC cis rs7918232 0.941 rs10829195 chr10:27431564 G/A cg14442939 chr10:27389572 ANKRD26 0.82 9.16 0.45 5.68e-18 Breast cancer; CRC trans rs7819412 0.668 rs4841507 chr8:11046394 C/G cg16141378 chr3:129829833 LOC729375 0.42 6.4 0.33 5.2e-10 Triglycerides; CRC cis rs911555 0.511 rs8007489 chr14:104054572 A/G cg24130564 chr14:104152367 KLC1 0.72 12.02 0.55 7.59e-28 Intelligence (multi-trait analysis); CRC cis rs34779708 0.931 rs4934720 chr10:35376800 T/C cg03585969 chr10:35415529 CREM 0.66 8.8 0.44 7.85e-17 Inflammatory bowel disease;Crohn's disease; CRC cis rs1799949 0.894 rs71367985 chr17:41374463 G/A cg05368731 chr17:41323189 NBR1 0.62 9.4 0.46 9.26e-19 Menopause (age at onset); CRC cis rs140364877 1 rs140364877 chr7:1885178 C/T cg04267008 chr7:1944627 MAD1L1 -0.65 -9.44 -0.46 7.25e-19 Autism spectrum disorder or schizophrenia; CRC trans rs9914544 0.564 rs8072860 chr17:18807884 T/C cg21372672 chr17:16614065 CCDC144A -0.39 -6.27 -0.33 1.14e-9 Educational attainment (years of education); CRC cis rs10256972 0.616 rs4998392 chr7:1113344 A/C cg03188948 chr7:1209495 NA 0.42 6.09 0.32 3.24e-9 Longevity;Endometriosis; CRC cis rs11098499 0.863 rs11736416 chr4:120431661 C/T cg24375607 chr4:120327624 NA 0.47 7.17 0.37 5.06e-12 Corneal astigmatism; CRC cis rs1552244 1.000 rs55822690 chr3:10128003 A/G cg10729496 chr3:10149963 C3orf24 0.55 7.31 0.37 2.06e-12 Alzheimer's disease; CRC cis rs4891159 0.790 rs72975930 chr18:74144645 G/A cg24786174 chr18:74118243 ZNF516 -0.85 -14.62 -0.63 1.17e-37 Longevity; CRC trans rs2727020 0.521 rs7107178 chr11:49526668 G/A cg03929089 chr4:120376271 NA 0.76 10.12 0.49 4e-21 Coronary artery disease; CRC cis rs1865760 1.000 rs9467636 chr6:25919549 A/C cg16482183 chr6:26056742 HIST1H1C 0.54 7.79 0.39 8.74e-14 Height; CRC cis rs4713118 0.824 rs9468229 chr6:27750086 G/A cg15786705 chr6:28176104 NA 0.54 7.06 0.36 1.01e-11 Parkinson's disease; CRC cis rs9467773 0.620 rs9461275 chr6:26590801 C/T cg09904177 chr6:26538194 HMGN4 0.73 11.54 0.54 4.38e-26 Intelligence (multi-trait analysis); CRC cis rs270601 0.770 rs61352298 chr5:131600589 G/C cg27615366 chr5:131592974 PDLIM4 0.34 6.48 0.34 3.38e-10 Acylcarnitine levels; CRC cis rs7809950 0.834 rs3801946 chr7:107242995 T/A cg23024343 chr7:107201750 COG5 0.64 9.15 0.45 6.22e-18 Coronary artery disease; CRC cis rs17270561 0.609 rs4711096 chr6:25727054 A/G cg17691542 chr6:26056736 HIST1H1C 0.73 9.27 0.46 2.56e-18 Iron status biomarkers; CRC cis rs7959452 0.640 rs4761154 chr12:69705362 A/G cg22834771 chr12:69754056 YEATS4 0.41 5.81 0.31 1.46e-8 Blood protein levels; CRC cis rs4713118 0.869 rs7776351 chr6:27726731 A/G cg26587870 chr6:27730563 NA 0.43 6.77 0.35 5.86e-11 Parkinson's disease; CRC cis rs1580019 0.520 rs13228793 chr7:32711465 C/T cg06627557 chr7:32535165 LSM5;AVL9 0.89 14.0 0.61 3e-35 Cognitive ability; CRC cis rs877282 0.838 rs34778553 chr10:796865 T/C cg17470449 chr10:769945 NA 0.66 8.79 0.44 8.55e-17 Uric acid levels; CRC cis rs7224685 0.501 rs781825 chr17:3966064 A/G cg21851534 chr17:3907994 ZZEF1 0.36 6.26 0.33 1.2e-9 Type 2 diabetes; CRC trans rs9329221 0.521 rs17693945 chr8:10106010 C/T cg06636001 chr8:8085503 FLJ10661 -0.61 -8.8 -0.44 8.15e-17 Neuroticism; CRC cis rs3204270 0.639 rs79193599 chr17:79651490 C/A cg09655341 chr17:79618100 PDE6G 0.61 6.41 0.33 4.93e-10 Dental caries; CRC cis rs9527 0.590 rs10883836 chr10:104891198 T/C cg04362960 chr10:104952993 NT5C2 0.6 8.32 0.42 2.32e-15 Arsenic metabolism; CRC cis rs6445967 1.000 rs62258069 chr3:58315263 A/T cg23715586 chr3:58305044 RPP14 0.37 6.01 0.31 4.82e-9 Platelet count; CRC cis rs9814567 1.000 rs7433991 chr3:134312292 A/T cg06109529 chr3:134205091 CEP63;ANAPC13 -0.8 -11.7 -0.54 1.13e-26 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC trans rs3749237 1.000 rs3749237 chr3:49770032 C/T cg21665057 chr3:196295764 WDR53;FBXO45 0.58 8.26 0.41 3.58e-15 Resting heart rate; CRC cis rs11203032 0.831 rs11203017 chr10:90948709 C/T cg16672925 chr10:90967113 CH25H 0.46 5.79 0.3 1.66e-8 Heart failure; CRC cis rs875971 1.000 rs709595 chr7:65817333 G/C cg11764359 chr7:65958608 NA 0.62 10.03 0.48 7.58e-21 Aortic root size; CRC cis rs8062405 0.824 rs28698667 chr16:28533071 C/T cg16576597 chr16:28551801 NUPR1 0.49 7.46 0.38 7.89e-13 Cognitive ability (multi-trait analysis);Cognitive ability; CRC cis rs4731207 0.698 rs12538083 chr7:124554057 T/C cg23710748 chr7:124431027 NA -0.37 -6.0 -0.31 5.3300000000000004e-09 Cutaneous malignant melanoma; CRC cis rs727563 0.569 rs73178647 chr22:41964168 G/A cg06634786 chr22:41940651 POLR3H -0.65 -6.95 -0.36 1.91e-11 Crohn's disease;Inflammatory bowel disease; CRC cis rs9858542 0.953 rs9811982 chr3:49624377 A/C cg00383909 chr3:49044727 WDR6 0.45 5.66 0.3 3.24e-8 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs10540 1.000 rs79808876 chr11:465763 C/A cg19913688 chr11:428466 ANO9 -0.72 -7.54 -0.38 4.53e-13 Body mass index; CRC cis rs28386778 0.701 rs2727337 chr17:61991966 G/A cg23090583 chr17:61904693 PSMC5;FTSJ3 -0.85 -14.05 -0.61 1.81e-35 Prudent dietary pattern; CRC trans rs11165623 0.564 rs9887887 chr1:96996930 A/G cg10631902 chr5:14652156 NA -0.4 -6.94 -0.36 2.11e-11 Hip circumference;Waist circumference; CRC cis rs6582630 0.577 rs12312748 chr12:38343326 T/C cg26384229 chr12:38710491 ALG10B -0.53 -7.61 -0.39 2.98e-13 Drug-induced liver injury (flucloxacillin); CRC cis rs7635838 0.596 rs347598 chr3:11258289 G/C cg00170343 chr3:11313890 ATG7 0.51 7.9 0.4 4.1e-14 HDL cholesterol; CRC cis rs6901250 1.000 rs6924002 chr6:117114223 A/T cg12892004 chr6:117198278 RFX6 0.43 6.68 0.35 9.93e-11 C-reactive protein levels; CRC cis rs62458065 0.713 rs28421905 chr7:32489501 G/A cg20159608 chr7:32802032 NA -0.59 -7.37 -0.38 1.36e-12 Metabolite levels (HVA/MHPG ratio); CRC cis rs7677751 0.806 rs4864863 chr4:55100831 A/G cg17187183 chr4:55093834 PDGFRA 0.51 7.27 0.37 2.72e-12 Corneal astigmatism; CRC cis rs4589502 1.000 rs8023363 chr15:67154654 G/A cg12317470 chr15:67143691 NA 0.71 7.26 0.37 2.78e-12 Lung cancer (smoking interaction); CRC cis rs13064411 0.542 rs9877649 chr3:113226874 C/T cg18753928 chr3:113234510 CCDC52 -0.53 -8.13 -0.41 8.8e-15 Response to simvastatin treatment (PCSK9 protein level change); CRC cis rs873946 0.564 rs12772704 chr10:134557318 G/A cg26818010 chr10:134567672 INPP5A -0.68 -8.51 -0.42 6.4e-16 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CRC cis rs6502050 0.835 rs8067138 chr17:80111026 T/C cg19223190 chr17:80058835 NA 0.4 6.36 0.33 6.88e-10 Life satisfaction; CRC cis rs1552244 0.882 rs13063929 chr3:10010308 T/C cg16606324 chr3:10149918 C3orf24 0.63 8.25 0.41 3.83e-15 Alzheimer's disease; CRC cis rs2408955 0.522 rs2051851 chr12:48485940 G/C cg24011408 chr12:48396354 COL2A1 -0.44 -6.47 -0.34 3.47e-10 Glycated hemoglobin levels; CRC cis rs950776 0.518 rs8053 chr15:78841220 T/C cg06917634 chr15:78832804 PSMA4 -0.65 -10.44 -0.5 3.21e-22 Sudden cardiac arrest; CRC cis rs9926296 0.565 rs8055825 chr16:89832848 C/T cg04287289 chr16:89883240 FANCA 0.81 14.33 0.62 1.58e-36 Vitiligo; CRC cis rs9287719 0.593 rs13009015 chr2:10763118 T/A cg00105475 chr2:10696890 NA 0.47 7.12 0.37 6.73e-12 Prostate cancer; CRC cis rs7617480 0.585 rs7373072 chr3:48960017 T/A cg07636037 chr3:49044803 WDR6 0.86 11.68 0.54 1.38e-26 Subjective well-being (multi-trait analysis);Menarche (age at onset); CRC cis rs9527 0.590 rs11191553 chr10:104851396 G/T cg15744005 chr10:104629667 AS3MT -0.31 -6.18 -0.32 1.86e-9 Arsenic metabolism; CRC trans rs1413885 1.000 rs1536174 chr1:65813709 G/C cg26534493 chr8:28060551 NA -0.37 -6.01 -0.31 5e-9 Anticoagulant levels; CRC cis rs4819052 0.851 rs2838843 chr21:46669284 T/C cg11663144 chr21:46675770 NA -0.84 -14.46 -0.62 4.99e-37 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs2239547 0.618 rs3733047 chr3:52871929 A/G cg18404041 chr3:52824283 ITIH1 0.42 7.65 0.39 2.27e-13 Schizophrenia; CRC cis rs2067615 0.507 rs11113083 chr12:107073316 C/A cg13491945 chr12:107078410 RFX4 0.36 6.16 0.32 2.13e-9 Heart rate; CRC cis rs76793172 0.660 rs3760843 chr19:46288706 A/T cg11657440 chr19:46296263 DMWD -0.56 -5.96 -0.31 6.65e-9 Eosinophil counts; CRC cis rs6088580 0.634 rs2378134 chr20:32938085 C/T cg08999081 chr20:33150536 PIGU -0.65 -12.07 -0.55 5.12e-28 Glomerular filtration rate (creatinine); CRC cis rs7793919 0.726 rs10261971 chr7:4776547 A/G cg09789173 chr7:4769017 FOXK1 0.76 12.66 0.57 3.53e-30 Mosquito bite size; CRC cis rs1005277 0.505 rs200935 chr10:38132810 T/A cg00409905 chr10:38381863 ZNF37A -0.64 -10.64 -0.51 6.5e-23 Extrinsic epigenetic age acceleration; CRC cis rs12701220 0.655 rs34696066 chr7:1140919 C/T cg26240231 chr7:1148101 C7orf50 -0.42 -6.04 -0.32 4.14e-9 Bronchopulmonary dysplasia; CRC cis rs9611565 0.579 rs73178621 chr22:41921665 A/G cg17554472 chr22:41940697 POLR3H -0.57 -5.96 -0.31 6.34e-9 Vitiligo; CRC cis rs7274811 0.688 rs56234419 chr20:32086447 C/T cg07470512 chr20:32255052 NECAB3;C20orf134 -0.45 -5.98 -0.31 5.84e-9 Height; CRC trans rs3733585 0.699 rs7657340 chr4:9966772 A/T cg26043149 chr18:55253948 FECH -0.49 -7.42 -0.38 9.82e-13 Cleft plate (environmental tobacco smoke interaction); CRC cis rs394563 0.967 rs420099 chr6:149794290 A/C cg03678062 chr6:149772716 ZC3H12D -0.37 -6.38 -0.33 5.98e-10 Dupuytren's disease; CRC cis rs6840360 0.642 rs1443089 chr4:152450300 A/G cg09659197 chr4:152720779 NA 0.33 6.66 0.34 1.14e-10 Intelligence (multi-trait analysis); CRC cis rs2734839 0.964 rs11214605 chr11:113300601 C/T cg14159747 chr11:113255604 NA 0.49 8.65 0.43 2.28e-16 Information processing speed; CRC cis rs2932538 0.885 rs7516421 chr1:113089696 T/C cg22162597 chr1:113214053 CAPZA1 0.59 8.65 0.43 2.3e-16 Systolic blood pressure;Diastolic blood pressure;Hypertension;Blood pressure; CRC cis rs514406 0.861 rs551435 chr1:53260537 G/T cg27535305 chr1:53392650 SCP2 0.39 6.97 0.36 1.72e-11 Monocyte count; CRC cis rs11212617 0.967 rs60683001 chr11:108257787 T/C cg14761454 chr11:108092087 ATM;NPAT 0.44 6.63 0.34 1.39e-10 Response to metformin in type 2 diabetes (glycemic); CRC cis rs9287719 0.967 rs9679581 chr2:10751736 G/A cg00105475 chr2:10696890 NA 0.45 7.17 0.37 4.86e-12 Prostate cancer; CRC cis rs3888647 0.622 rs4758618 chr11:2995186 A/T cg25174290 chr11:3078921 CARS 0.41 6.33 0.33 8.21e-10 Type 2 diabetes; CRC cis rs9503598 0.662 rs2326232 chr6:3451953 A/G cg00476032 chr6:3446245 SLC22A23 0.45 7.21 0.37 3.75e-12 Cognitive ability (multi-trait analysis);Cognitive ability;Intelligence (multi-trait analysis); CRC cis rs2303759 0.918 rs9749416 chr19:49885005 G/A cg22590775 chr19:49891494 CCDC155 0.61 8.9 0.44 3.71e-17 Multiple sclerosis; CRC cis rs3733585 0.699 rs6449202 chr4:9974043 T/C cg00071950 chr4:10020882 SLC2A9 -0.55 -9.87 -0.48 2.66e-20 Cleft plate (environmental tobacco smoke interaction); CRC cis rs1697139 0.583 rs6895853 chr5:66541427 T/C cg11553311 chr5:66541588 NA 0.58 9.87 0.48 2.72e-20 Breast cancer; CRC cis rs738322 0.967 rs132971 chr22:38561911 T/G cg25457927 chr22:38595422 NA -0.36 -7.42 -0.38 1.04e-12 Cutaneous nevi; CRC cis rs1712517 0.771 rs7921655 chr10:105113701 C/T cg05636881 chr10:105038444 INA 0.48 8.22 0.41 4.68e-15 Migraine; CRC cis rs1178968 1.000 rs1178959 chr7:72777093 T/C cg25889504 chr7:72793014 NA 0.54 6.12 0.32 2.63e-9 Triglyceride levels; CRC cis rs7301826 0.651 rs12228957 chr12:131296066 T/C cg11011512 chr12:131303247 STX2 0.37 5.62 0.3 4.1e-8 Plasma plasminogen activator levels; CRC cis rs9768139 0.733 rs13225172 chr7:158120334 G/A cg06219351 chr7:158114137 PTPRN2 -0.51 -7.64 -0.39 2.45e-13 Calcium levels; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg12393716 chr11:62495049 TTC9C;HNRNPUL2 0.43 6.08 0.32 3.32e-9 Response to antipsychotic treatment; CRC cis rs6502050 0.626 rs11868521 chr17:80100195 T/G cg19223190 chr17:80058835 NA -0.42 -6.42 -0.33 4.88e-10 Life satisfaction; CRC cis rs2949837 0.581 rs2965074 chr7:45983129 G/T cg06713098 chr7:45960367 IGFBP3 0.42 6.65 0.34 1.25e-10 Sitting height ratio; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg09501006 chr9:78505549 PCSK5 0.46 6.76 0.35 6.18e-11 Intelligence (multi-trait analysis); CRC cis rs10461617 0.531 rs2662033 chr5:56213410 T/G cg12311346 chr5:56204834 C5orf35 -0.86 -12.08 -0.55 4.55e-28 Type 2 diabetes; CRC cis rs9399135 1.000 rs9399135 chr6:135368314 G/A cg24558204 chr6:135376177 HBS1L 0.47 7.12 0.37 6.98e-12 Red blood cell count; CRC cis rs524281 0.682 rs4483592 chr11:65990439 C/T cg14036092 chr11:66035641 RAB1B -0.56 -6.36 -0.33 6.73e-10 Electroencephalogram traits; CRC cis rs597539 0.652 rs1249474 chr11:68654774 C/T cg04772025 chr11:68637568 NA 0.47 7.4 0.38 1.16e-12 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC trans rs3931020 0.720 rs927904 chr1:75260328 A/G cg24361086 chr7:123388661 WASL 0.49 6.16 0.32 2.07e-9 Resistin levels; CRC cis rs9733 0.525 rs11584184 chr1:150695689 A/T cg15448220 chr1:150897856 SETDB1 0.45 6.41 0.33 5.09e-10 Tonsillectomy; CRC cis rs4819052 0.851 rs875621 chr21:46682295 A/G cg02159808 chr21:46707872 POFUT2;LOC642852 0.51 6.62 0.34 1.44e-10 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs62158211 1.000 rs4618068 chr2:114109355 C/T cg17784749 chr2:114082611 LOC440839 0.56 6.49 0.34 3.15e-10 Sleep duration (oversleepers vs undersleepers);Sleep traits (multi-trait analysis);Sleep duration; CRC trans rs1005277 0.579 rs2474580 chr10:38398713 G/A cg23533926 chr12:111358616 MYL2 -0.52 -7.82 -0.4 7.43e-14 Extrinsic epigenetic age acceleration; CRC cis rs7937682 0.924 rs10891286 chr11:111532691 C/G cg09085632 chr11:111637200 PPP2R1B -1.0 -20.52 -0.75 7.88e-61 Primary sclerosing cholangitis; CRC cis rs7937682 0.889 rs3017767 chr11:111508098 A/G cg09085632 chr11:111637200 PPP2R1B -0.99 -19.28 -0.73 5.84e-56 Primary sclerosing cholangitis; CRC cis rs1448094 0.872 rs10863147 chr12:86408441 G/C cg02569458 chr12:86230093 RASSF9 0.4 6.66 0.34 1.12e-10 Major depressive disorder; CRC trans rs9291683 0.551 rs62295971 chr4:9978142 G/A cg26043149 chr18:55253948 FECH 0.54 8.28 0.42 3.09e-15 Bone mineral density; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg05314606 chr18:46478925 NA 0.45 6.3 0.33 9.58e-10 Response to antipsychotic treatment; CRC cis rs8060686 0.623 rs12599178 chr16:68128104 A/G cg26727032 chr16:67993705 SLC12A4 -0.62 -9.97 -0.48 1.29e-20 HDL cholesterol;Metabolic syndrome; CRC cis rs9291683 0.588 rs3756238 chr4:10013202 C/T cg11266682 chr4:10021025 SLC2A9 0.54 11.57 0.54 3.2e-26 Bone mineral density; CRC cis rs477692 0.673 rs487120 chr10:131367552 C/T cg05714579 chr10:131428358 MGMT 0.48 6.65 0.34 1.25e-10 Response to temozolomide; CRC cis rs597539 0.689 rs596874 chr11:68630874 C/T cg06112835 chr11:68658793 MRPL21 -0.42 -7.09 -0.36 8.2e-12 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs9926296 0.605 rs886951 chr16:89836865 A/G cg04287289 chr16:89883240 FANCA 0.82 14.75 0.63 3.69e-38 Vitiligo; CRC trans rs909848 0.583 rs479934 chr1:71442206 C/T cg23933503 chr22:44255884 SULT4A1 -0.39 -6.07 -0.32 3.47e-9 IgG glycosylation; CRC cis rs4975709 0.589 rs1466606 chr5:1865055 C/T cg20790798 chr5:1857306 NA -0.45 -6.82 -0.35 4.3e-11 Cardiovascular disease risk factors; CRC cis rs4499344 0.633 rs259262 chr19:33153951 G/A cg08127369 chr19:33164662 ANKRD27 0.39 5.95 0.31 6.82e-9 Mean platelet volume; CRC cis rs875971 0.619 rs12533585 chr7:65984605 G/C cg25985355 chr7:65971099 NA -0.32 -5.67 -0.3 3.12e-8 Aortic root size; CRC cis rs6952808 1.000 rs6977733 chr7:1886725 A/T cg02951883 chr7:2050386 MAD1L1 0.73 11.48 0.53 7.02e-26 Bipolar disorder and schizophrenia; CRC cis rs910316 1.000 rs4903284 chr14:75592483 G/C cg03030879 chr14:75389066 RPS6KL1 -0.47 -7.39 -0.38 1.2e-12 Height; CRC cis rs9326248 0.817 rs1242127 chr11:117076564 A/G cg20608306 chr11:116969690 SIK3 -0.3 -5.62 -0.3 4.04e-8 Blood protein levels; CRC cis rs68170813 0.559 rs4515482 chr7:107072681 A/C cg02696742 chr7:106810147 HBP1 -0.53 -6.05 -0.32 3.93e-9 Coronary artery disease; CRC cis rs909002 0.830 rs10914461 chr1:32113217 G/A cg01639898 chr1:32083012 HCRTR1 0.3 6.28 0.33 1.1e-9 Intelligence (multi-trait analysis); CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg26708280 chr2:190649305 PMS1;ORMDL1 0.54 7.08 0.36 8.85e-12 Thyroid stimulating hormone; CRC cis rs11969893 0.850 rs9498414 chr6:101322976 C/T cg12253828 chr6:101329408 ASCC3 1.05 8.48 0.42 7.47e-16 Economic and political preferences (immigration/crime); CRC cis rs72634258 0.945 rs12753070 chr1:8114319 C/G cg26816564 chr1:7831052 VAMP3 0.58 6.32 0.33 8.47e-10 Inflammatory bowel disease; CRC cis rs79349575 0.749 rs8182364 chr17:47018025 A/G cg00947319 chr17:47005597 UBE2Z -0.34 -5.89 -0.31 9.32e-9 Type 2 diabetes; CRC cis rs7618501 0.602 rs2240326 chr3:50128386 G/A cg05623727 chr3:50126028 RBM5 -0.45 -7.38 -0.38 1.33e-12 Intelligence (multi-trait analysis); CRC cis rs372883 0.613 rs1153289 chr21:30686212 G/T cg08807101 chr21:30365312 RNF160 -0.51 -7.18 -0.37 4.65e-12 Pancreatic cancer; CRC cis rs11098499 0.863 rs10018280 chr4:120478139 T/G cg09307838 chr4:120376055 NA 0.68 10.09 0.49 4.79e-21 Corneal astigmatism; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg03661160 chr7:97881541 TECPR1 0.45 7.36 0.38 1.45e-12 Liver disease severity in Alagille syndrome; CRC cis rs3008870 0.959 rs2985816 chr1:67387750 G/T cg08660285 chr1:67390436 MIER1;WDR78 1.04 16.07 0.66 2.57e-43 Lymphocyte percentage of white cells; CRC cis rs12545109 0.800 rs2610052 chr8:57411316 C/A cg09654669 chr8:57350985 NA -0.46 -7.43 -0.38 9.15e-13 Obesity-related traits; CRC cis rs17270561 0.609 rs9467572 chr6:25704126 T/G cg17691542 chr6:26056736 HIST1H1C -0.63 -8.02 -0.4 1.91e-14 Iron status biomarkers; CRC cis rs13382862 0.895 rs13385499 chr2:20882413 A/G cg07755735 chr2:20870362 GDF7 -0.38 -6.72 -0.35 7.93e-11 Abdominal aortic aneurysm; CRC cis rs35146811 0.735 rs1636975 chr7:99812089 A/G cg13334819 chr7:99746414 C7orf59 0.51 6.71 0.35 8.67e-11 Coronary artery disease; CRC cis rs7786808 0.608 rs6978352 chr7:158209802 T/C cg15440763 chr7:158190612 PTPRN2 -0.41 -6.64 -0.34 1.28e-10 Obesity-related traits; CRC cis rs1577917 1.000 rs13199006 chr6:86608708 T/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.51 -6.86 -0.35 3.34e-11 Response to antipsychotic treatment; CRC cis rs12148488 0.966 rs1867148 chr15:75339985 T/C cg18612461 chr15:75251733 NA -0.37 -5.64 -0.3 3.57e-8 Caffeine consumption; CRC cis rs6840360 1.000 rs28710456 chr4:152667171 T/C cg09659197 chr4:152720779 NA 0.53 11.71 0.54 1.06e-26 Intelligence (multi-trait analysis); CRC cis rs898097 0.841 rs55810435 chr17:80836722 G/C cg15664640 chr17:80829946 TBCD -0.7 -11.76 -0.54 6.76e-27 Breast cancer; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg02308097 chr17:79868996 PCYT2 0.45 6.33 0.33 8.1e-10 Anxiety disorder; CRC cis rs1865760 1.000 rs3799371 chr6:25912816 A/G cg16482183 chr6:26056742 HIST1H1C -0.54 -7.9 -0.4 4.27e-14 Height; CRC cis rs60733400 0.782 rs4648564 chr1:2562169 C/T cg20673091 chr1:2541236 MMEL1 -0.37 -5.89 -0.31 9.8e-9 Multiple sclerosis; CRC cis rs9914988 0.943 rs9890155 chr17:27125467 A/G cg20469991 chr17:27169893 C17orf63 -0.6 -7.27 -0.37 2.59e-12 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs908922 0.676 rs1572533 chr1:152509742 T/C cg23254163 chr1:152506842 NA 0.45 8.66 0.43 2.2e-16 Hair morphology; CRC cis rs875971 0.660 rs7807930 chr7:66087165 C/T cg00343986 chr7:65444356 GUSB -0.5 -7.46 -0.38 7.61e-13 Aortic root size; CRC cis rs9420 0.961 rs11601320 chr11:57642617 T/C cg23127183 chr11:57508653 C11orf31 -0.53 -7.1 -0.36 7.73e-12 Schizophrenia; CRC cis rs2294693 0.853 rs9296350 chr6:40977623 G/A cg14769373 chr6:40998127 UNC5CL -0.48 -6.61 -0.34 1.56e-10 Gastric cancer;Non-cardia gastric cancer; CRC cis rs17826219 0.568 rs7213925 chr17:29121634 A/G cg13385521 chr17:29058706 SUZ12P 0.73 8.38 0.42 1.53e-15 Body mass index; CRC cis rs727505 1.000 rs66513837 chr7:124492763 A/G cg23710748 chr7:124431027 NA -0.85 -15.05 -0.64 2.48e-39 Lewy body disease; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg05332869 chr20:39658073 TOP1 0.44 6.04 0.32 4.27e-9 Response to antipsychotic treatment; CRC trans rs61931739 0.534 rs1843733 chr12:34047626 T/C cg26384229 chr12:38710491 ALG10B 0.48 6.57 0.34 1.92e-10 Morning vs. evening chronotype; CRC cis rs13256369 0.951 rs12679360 chr8:8566269 G/T cg17143192 chr8:8559678 CLDN23 -0.45 -5.6 -0.3 4.48e-8 Obesity-related traits; CRC cis rs4290604 0.748 rs12692198 chr2:238057391 C/A cg23555395 chr2:238036564 NA -0.67 -6.81 -0.35 4.62e-11 Asthma; CRC cis rs9649213 0.593 rs7787858 chr7:98009914 T/C cg21770322 chr7:97807741 LMTK2 0.52 8.48 0.42 7.81e-16 Prostate cancer (SNP x SNP interaction); CRC cis rs6594499 0.872 rs6865932 chr5:110436852 G/C cg04022379 chr5:110408740 TSLP 0.47 7.3 0.37 2.17e-12 Allergic disease (asthma, hay fever or eczema); CRC cis rs7408868 0.656 rs1043997 chr19:15292437 T/C cg14696996 chr19:15285081 NOTCH3 0.53 6.2 0.32 1.71e-9 Pulse pressure; CRC cis rs6500602 0.626 rs7665 chr16:4562512 A/G cg06139259 chr16:4526053 HMOX2;NMRAL1 0.49 6.25 0.33 1.26e-9 Schizophrenia; CRC cis rs12908161 1.000 rs17601029 chr15:85347709 A/G cg11189052 chr15:85197271 WDR73 0.57 8.19 0.41 5.99e-15 Schizophrenia; CRC cis rs3733585 0.631 rs7699671 chr4:10125874 C/T cg11266682 chr4:10021025 SLC2A9 -0.47 -8.76 -0.43 1.08e-16 Cleft plate (environmental tobacco smoke interaction); CRC trans rs9826463 0.757 rs79576118 chr3:142244645 A/C cg13928417 chr9:124498782 DAB2IP -0.53 -5.97 -0.31 6.09e-9 QRS duration in Tripanosoma cruzi seropositivity; CRC cis rs7666738 0.830 rs3852122 chr4:98697400 T/C cg17366294 chr4:99064904 C4orf37 0.4 6.66 0.34 1.12e-10 Colonoscopy-negative controls vs population controls; CRC cis rs6503525 0.591 rs8080734 chr17:38103285 G/A cg00129232 chr17:37814104 STARD3 0.37 5.61 0.3 4.19e-8 Asthma; CRC cis rs11785693 0.862 rs11778367 chr8:4988398 T/C cg26367366 chr8:4980734 NA 0.79 9.75 0.47 6.64e-20 Neuroticism (multi-trait analysis);Neuroticism; CRC cis rs7246657 0.943 rs3760825 chr19:37945601 C/T cg23950597 chr19:37808831 NA -0.49 -6.05 -0.32 3.93e-9 Coronary artery calcification; CRC cis rs10504229 0.728 rs72650858 chr8:58152832 G/A cg22535103 chr8:58192502 C8orf71 -0.68 -8.37 -0.42 1.72e-15 Developmental language disorder (linguistic errors); CRC trans rs8002861 0.664 rs2218497 chr13:44428793 G/A cg17145862 chr1:211918768 LPGAT1 0.57 9.92 0.48 1.87e-20 Leprosy; CRC cis rs9462027 0.628 rs9469894 chr6:34774725 T/C cg07306190 chr6:34760872 UHRF1BP1 -0.34 -6.03 -0.32 4.37e-9 Systemic lupus erythematosus; CRC cis rs3806843 0.576 rs246066 chr5:140323147 T/G cg19875535 chr5:140030758 IK 0.41 6.26 0.33 1.23e-9 Depressive symptoms (multi-trait analysis); CRC cis rs10256972 0.758 rs7799391 chr7:1082566 C/G cg03188948 chr7:1209495 NA 0.43 6.29 0.33 9.85e-10 Longevity;Endometriosis; CRC cis rs2274273 0.624 rs7159824 chr14:55772536 C/T cg10130446 chr14:55658398 DLGAP5 -0.4 -5.74 -0.3 2.18e-8 Protein biomarker; CRC cis rs1707322 1.000 rs4073847 chr1:46463012 A/C cg06784218 chr1:46089804 CCDC17 -0.5 -8.69 -0.43 1.78e-16 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs13256369 1.000 rs4841016 chr8:8572561 C/T cg06671706 chr8:8559999 CLDN23 0.56 8.13 0.41 8.9e-15 Obesity-related traits; CRC cis rs28386778 0.562 rs721575 chr17:61782920 A/G cg06601766 chr17:61851465 DDX42;CCDC47 -0.44 -6.14 -0.32 2.38e-9 Prudent dietary pattern; CRC cis rs7412746 0.566 rs2864871 chr1:150766964 T/C cg18016565 chr1:150552671 MCL1 0.43 5.98 0.31 5.83e-9 Melanoma; CRC trans rs2303319 0.504 rs62189041 chr2:162599506 T/C cg18122310 chr12:50236657 BCDIN3D -0.73 -6.35 -0.33 7.23e-10 Cognitive function; CRC cis rs965469 0.779 rs6051746 chr20:3307290 C/G cg25506879 chr20:3388711 C20orf194 -0.37 -5.66 -0.3 3.37e-8 IFN-related cytopenia; CRC cis rs728616 0.558 rs116434658 chr10:81754626 G/A cg05935833 chr10:81318306 SFTPA2 -0.55 -7.13 -0.37 6.42e-12 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs2075371 0.863 rs2075370 chr7:133967812 A/G cg20476274 chr7:133979776 SLC35B4 0.78 14.11 0.61 1.13e-35 Mean platelet volume; CRC cis rs2721195 1.000 rs11542372 chr8:145677089 G/A cg15857475 chr8:145742913 RECQL4;LRRC14 -0.72 -12.34 -0.56 5.1e-29 Age at first birth; CRC cis rs10504229 0.953 rs75585481 chr8:58192202 T/C cg01721255 chr8:58191610 C8orf71 0.49 6.17 0.32 2e-9 Developmental language disorder (linguistic errors); CRC cis rs9560113 1.000 rs9560103 chr13:112174253 G/A cg14154082 chr13:112174009 NA 0.35 5.71 0.3 2.54e-8 Menarche (age at onset); CRC cis rs4481887 0.927 rs10127803 chr1:248476196 A/T cg00666640 chr1:248458726 OR2T12 0.45 7.8 0.4 8.31e-14 Common traits (Other); CRC trans rs62103177 0.759 rs7227794 chr18:77610925 C/T cg05926928 chr17:57297772 GDPD1 1.18 12.4 0.56 3.09e-29 Opioid sensitivity; CRC trans rs208520 1.000 rs72882079 chr6:66973878 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.89 10.97 0.52 4.54e-24 Exhaled nitric oxide output; CRC cis rs2806561 0.729 rs649664 chr1:23324263 C/T cg19743168 chr1:23544995 NA -0.35 -5.63 -0.3 3.89e-8 Height; CRC cis rs4862750 0.872 rs4862747 chr4:187877236 A/T cg07414643 chr4:187882934 NA -0.41 -7.27 -0.37 2.67e-12 Lobe attachment (rater-scored or self-reported); CRC trans rs9291683 0.567 rs12499857 chr4:9995376 G/A cg26043149 chr18:55253948 FECH 0.53 8.21 0.41 5.13e-15 Bone mineral density; CRC cis rs7647973 0.848 rs4292260 chr3:49148890 T/C cg07636037 chr3:49044803 WDR6 0.84 10.35 0.5 6.46e-22 Menarche (age at onset); CRC cis rs8180040 0.932 rs11711265 chr3:47558448 T/C cg10298567 chr3:47292165 KIF9 -0.36 -5.96 -0.31 6.33e-9 Colorectal cancer; CRC cis rs1538970 0.924 rs11211111 chr1:45908782 C/T cg05343316 chr1:45956843 TESK2 0.74 9.85 0.48 3.12e-20 Platelet count; CRC cis rs56399783 0.901 rs55767077 chr7:2774608 C/T cg19731401 chr7:2775893 GNA12 0.66 7.14 0.37 5.98e-12 Childhood ear infection; CRC cis rs847577 0.609 rs6965016 chr7:97807882 C/A cg24562669 chr7:97807699 LMTK2 0.8 17.62 0.7 2.1e-49 Breast cancer; CRC cis rs10256972 0.706 rs4285396 chr7:1123738 A/G cg23708337 chr7:1209742 NA 0.43 6.37 0.33 6.55e-10 Longevity;Endometriosis; CRC trans rs6703335 0.870 rs10803142 chr1:243598234 A/G cg04369251 chr14:32671021 NA 0.43 6.09 0.32 3.09e-9 Schizophrenia;Schizophrenia, schizoaffective disorder or bipolar disorder; CRC cis rs80207740 1.000 rs17296501 chr8:21849566 C/T cg12468850 chr8:21767224 DOK2 -0.52 -6.08 -0.32 3.24e-9 Mean corpuscular hemoglobin; CRC cis rs13191362 1.000 rs35754151 chr6:163074867 A/G cg23758597 chr6:163146217 PARK2 -0.65 -6.58 -0.34 1.91e-10 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs6460942 0.556 rs10228123 chr7:12374025 A/C cg06484146 chr7:12443880 VWDE -0.54 -7.46 -0.38 8e-13 Coronary artery disease; CRC cis rs12497850 0.931 rs7623023 chr3:48914238 G/A cg20833759 chr3:49053208 WDR6;DALRD3 0.48 8.17 0.41 6.8e-15 Parkinson's disease; CRC cis rs1799949 1.000 rs1060915 chr17:41234470 A/G cg01879757 chr17:41196368 BRCA1 -0.4 -5.96 -0.31 6.61e-9 Menopause (age at onset); CRC cis rs10751667 0.666 rs7396677 chr11:958878 C/T ch.11.42038R chr11:967971 AP2A2 0.58 10.11 0.49 4.24e-21 Alzheimer's disease (late onset); CRC cis rs7772486 0.790 rs9403755 chr6:146231470 C/A cg23711669 chr6:146136114 FBXO30 -0.72 -12.64 -0.57 3.92e-30 Lobe attachment (rater-scored or self-reported); CRC cis rs5769765 0.908 rs138867 chr22:50207703 A/G cg08270630 chr22:50330655 NA 0.41 6.12 0.32 2.7e-9 Schizophrenia; CRC trans rs9826463 0.757 rs75100831 chr3:142244647 T/C cg13928417 chr9:124498782 DAB2IP -0.53 -5.97 -0.31 6.09e-9 QRS duration in Tripanosoma cruzi seropositivity; CRC cis rs8060686 0.858 rs10468274 chr16:67922342 C/T cg00318322 chr16:67708822 GFOD2 -0.32 -6.02 -0.32 4.53e-9 HDL cholesterol;Metabolic syndrome; CRC cis rs4243830 1.000 rs12027598 chr1:6600804 C/T cg22792644 chr1:6614718 TAS1R1;NOL9 0.77 6.77 0.35 6.01e-11 Body mass index; CRC cis rs1707322 0.963 rs10890371 chr1:46390897 T/G cg06784218 chr1:46089804 CCDC17 0.51 8.98 0.44 2.07e-17 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs911119 0.913 rs13043610 chr20:23586941 G/A cg16589663 chr20:23618590 CST3 0.56 7.27 0.37 2.64e-12 Chronic kidney disease; CRC cis rs7202877 0.610 rs7202284 chr16:75374346 A/T cg03315344 chr16:75512273 CHST6 0.5 5.96 0.31 6.52e-9 Type 2 diabetes;Type 1 diabetes; CRC cis rs34034915 1 rs34034915 chr6:27720703 T/TG cg26587870 chr6:27730563 NA -0.38 -5.95 -0.31 6.72e-9 Hepatitis A; CRC cis rs2239547 0.522 rs2581780 chr3:53058960 C/T cg18404041 chr3:52824283 ITIH1 0.34 6.21 0.32 1.6e-9 Schizophrenia; CRC cis rs7412746 0.611 rs72704679 chr1:150897477 C/T cg17724175 chr1:150552817 MCL1 0.4 6.15 0.32 2.27e-9 Melanoma; CRC cis rs2404602 0.735 rs2461871 chr15:76822418 C/G cg23625390 chr15:77176239 SCAPER -0.72 -11.23 -0.53 5.62e-25 Blood metabolite levels; CRC cis rs11105298 0.891 rs10858906 chr12:89934474 C/T cg08166232 chr12:89918718 WDR51B;GALNT4 -0.6 -7.34 -0.37 1.72e-12 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; CRC cis rs7208859 0.573 rs73277960 chr17:29177441 T/C cg13385521 chr17:29058706 SUZ12P 0.65 7.73 0.39 1.31e-13 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC trans rs2303319 0.504 rs62188987 chr2:162525686 T/A cg12500891 chr11:57225987 NA -0.67 -6.12 -0.32 2.62e-9 Cognitive function; CRC cis rs7703051 0.585 rs918623 chr5:74596682 A/C cg00601450 chr5:74908170 NA 0.4 5.6 0.3 4.48e-8 LDL cholesterol;Age-related disease endophenotypes;Age-related diseases, mortality and associated endophenotypes; CRC cis rs79349575 0.783 rs318096 chr17:46975370 G/A cg22482690 chr17:47019901 SNF8 0.48 8.09 0.41 1.2e-14 Type 2 diabetes; CRC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg07951810 chr12:65153561 GNS -0.44 -6.27 -0.33 1.11e-9 Asthma; CRC cis rs9381040 0.610 rs742495 chr6:41018233 A/G cg09580153 chr6:41068724 NFYA;LOC221442 -0.42 -6.17 -0.32 1.96e-9 Alzheimer's disease (late onset); CRC cis rs6502050 0.835 rs62078305 chr17:80085326 G/A cg11859384 chr17:80120422 CCDC57 0.37 5.82 0.31 1.36e-8 Life satisfaction; CRC cis rs13082711 0.911 rs11708710 chr3:27457348 A/C cg02860705 chr3:27208620 NA 0.62 8.76 0.43 1.04e-16 Systolic blood pressure;Diastolic blood pressure;Blood pressure; CRC cis rs3806843 0.868 rs2531349 chr5:140120953 G/A cg19875535 chr5:140030758 IK -0.52 -8.36 -0.42 1.75e-15 Depressive symptoms (multi-trait analysis); CRC cis rs7677751 0.806 rs4864859 chr4:55090015 A/G cg00691999 chr4:55094011 PDGFRA 0.44 6.46 0.34 3.74e-10 Corneal astigmatism; CRC cis rs4629710 0.534 rs6916881 chr6:131565153 C/T cg12606694 chr6:131520996 AKAP7 0.54 8.1 0.41 1.08e-14 Multiple myeloma (IgH translocation); CRC cis rs1209950 1.000 rs1013841 chr21:40173345 A/G cg02119577 chr21:40195074 ETS2 -0.37 -6.28 -0.33 1.08e-9 Non-small cell lung cancer (survival); CRC cis rs798554 0.634 rs6970963 chr7:2821271 C/T cg04166393 chr7:2884313 GNA12 0.41 6.27 0.33 1.1e-9 Height; CRC cis rs7811142 1.000 rs6975729 chr7:100028187 C/T cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.74 10.11 0.49 4.15e-21 Platelet count; CRC trans rs6956675 0.874 rs6968344 chr7:62574533 A/G cg01314568 chr7:57830625 NA -0.68 -9.31 -0.46 1.91e-18 Obesity-related traits; CRC cis rs9467711 0.651 rs35069699 chr6:25957282 C/T cg16898833 chr6:26189333 HIST1H4D 0.7 5.76 0.3 1.93e-8 Autism spectrum disorder or schizophrenia; CRC cis rs7572644 0.640 rs4666022 chr2:28057823 T/C cg27432699 chr2:27873401 GPN1 0.46 6.23 0.32 1.44e-9 Response to carboplatin and paclitaxel in ovarian cancer (Caspase 3/7 EC50); CRC cis rs6546550 0.901 rs11126251 chr2:70163434 A/C cg02498382 chr2:70120550 SNRNP27 -0.57 -9.72 -0.47 8.23e-20 Prevalent atrial fibrillation; CRC cis rs754466 0.580 rs10824575 chr10:79549047 A/G cg17075019 chr10:79541650 NA -0.99 -19.49 -0.73 8.32e-57 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs4700695 0.719 rs27588 chr5:65459360 C/A cg21114390 chr5:65439923 SFRS12 -0.66 -8.73 -0.43 1.34e-16 Facial morphology (factor 19); CRC trans rs8002861 0.619 rs9567289 chr13:44437104 C/T cg17145862 chr1:211918768 LPGAT1 0.57 9.93 0.48 1.73e-20 Leprosy; CRC trans rs7819412 0.521 rs10100660 chr8:11038885 T/A cg16141378 chr3:129829833 LOC729375 0.42 6.14 0.32 2.38e-9 Triglycerides; CRC trans rs13046373 0.905 rs4816372 chr21:32077414 A/T cg08852759 chr2:33701319 RASGRP3 -0.39 -6.14 -0.32 2.35e-9 HDL cholesterol; CRC cis rs7107174 1.000 rs10899454 chr11:77997513 T/C cg02023728 chr11:77925099 USP35 0.54 8.2 0.41 5.59e-15 Testicular germ cell tumor; CRC cis rs7412746 0.611 rs6660084 chr1:150748803 T/C cg10589385 chr1:150898437 SETDB1 0.3 6.08 0.32 3.34e-9 Melanoma; CRC cis rs2243480 1.000 rs1796220 chr7:66062100 C/T cg18252515 chr7:66147081 NA -1.27 -15.22 -0.64 5.52e-40 Diabetic kidney disease; CRC cis rs344364 0.602 rs12325217 chr16:1887108 A/T cg09830162 chr16:1889614 FAHD1;C16orf73 -0.56 -8.17 -0.41 6.83e-15 Glomerular filtration rate in chronic kidney disease; CRC cis rs4820539 0.641 rs5759602 chr22:23489362 C/T cg14186256 chr22:23484241 RTDR1 -0.81 -13.78 -0.6 2.11e-34 Bone mineral density; CRC cis rs7666738 0.830 rs880470 chr4:98922522 A/T cg05340658 chr4:99064831 C4orf37 0.6 9.35 0.46 1.41e-18 Colonoscopy-negative controls vs population controls; CRC cis rs873946 0.504 rs4880275 chr10:134576552 C/T cg18305652 chr10:134549665 INPP5A 0.53 7.57 0.39 3.7e-13 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CRC cis rs875971 0.545 rs6950988 chr7:65976415 C/T cg11764359 chr7:65958608 NA 0.46 5.82 0.31 1.39e-8 Aortic root size; CRC cis rs2070677 0.736 rs4498943 chr10:135422505 A/T cg20169779 chr10:135381914 SYCE1 0.79 10.84 0.51 1.32e-23 Gout; CRC cis rs7044106 0.791 rs7036196 chr9:123479457 A/G cg14255062 chr9:123606675 PSMD5;LOC253039 0.49 7.32 0.37 1.86e-12 Hip circumference adjusted for BMI; CRC cis rs12541335 0.639 rs11135995 chr8:22200148 C/T cg26039829 chr8:22132926 PIWIL2 -0.5 -8.72 -0.43 1.38e-16 Hypertriglyceridemia; CRC cis rs1552244 1.000 rs67569278 chr3:10149893 T/C cg00166722 chr3:10149974 C3orf24 0.68 8.84 0.44 5.82e-17 Alzheimer's disease; CRC cis rs4938330 0.512 rs4938327 chr11:116906728 T/C cg20608306 chr11:116969690 SIK3 -0.31 -5.81 -0.31 1.47e-8 Blood protein levels; CRC cis rs13031619 0.660 rs35668314 chr2:3702673 C/T cg25251562 chr2:3704773 ALLC -0.78 -9.7 -0.47 9.76e-20 Response to inhaled corticosteroid treatment in asthma (change in FEV1); CRC cis rs1881797 0.932 rs41305741 chr1:247689543 A/G cg21399703 chr1:247681439 NA 0.48 7.88 0.4 4.91e-14 Acute lymphoblastic leukemia (childhood); CRC cis rs7539542 0.556 rs6427979 chr1:202869503 T/C cg19681188 chr1:202830198 LOC148709 0.47 6.8 0.35 4.94e-11 Mean platelet volume; CRC cis rs7264396 0.887 rs224351 chr20:34052273 G/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.41 -6.61 -0.34 1.55e-10 Total cholesterol levels; CRC cis rs9533799 1.000 rs2282064 chr13:44805870 G/A cg19190762 chr13:44806055 NA 0.62 9.49 0.46 4.7e-19 Amyotrophic lateral sclerosis; CRC trans rs10983614 1.000 rs7867776 chr9:120072627 A/G cg06404838 chr11:117015391 PAFAH1B2 0.48 6.43 0.33 4.43e-10 Survival in pancreatic cancer; CRC cis rs992157 0.835 rs2271543 chr2:219142491 C/T cg04880052 chr2:219191631 PNKD -0.44 -6.96 -0.36 1.83e-11 Colorectal cancer; CRC cis rs4423214 0.840 rs1540127 chr11:71179038 G/A cg05163923 chr11:71159392 DHCR7 -0.63 -7.61 -0.39 2.85e-13 Vitamin D levels; CRC cis rs6582630 0.519 rs8189609 chr12:38281408 A/G cg26384229 chr12:38710491 ALG10B 0.69 9.22 0.45 3.69e-18 Drug-induced liver injury (flucloxacillin); CRC cis rs9768139 0.733 rs13221388 chr7:158119270 G/A cg24154853 chr7:158122151 PTPRN2 0.64 10.59 0.5 9.21e-23 Calcium levels; CRC cis rs7412746 0.658 rs7526489 chr1:150726238 C/T cg18016565 chr1:150552671 MCL1 0.42 5.83 0.31 1.36e-8 Melanoma; CRC cis rs10771431 0.597 rs10771413 chr12:9354413 C/T cg08997352 chr12:9597637 DDX12 -0.45 -6.69 -0.35 9.48e-11 Breast size; CRC cis rs9915657 0.870 rs4140902 chr17:70133750 A/G cg09344028 chr17:70110421 NA 0.44 6.73 0.35 7.58e-11 Thyroid hormone levels; CRC trans rs1005277 0.565 rs2474565 chr10:38380828 A/G cg27523141 chr10:43048294 ZNF37B 0.49 7.19 0.37 4.45e-12 Extrinsic epigenetic age acceleration; CRC cis rs1153858 1.000 rs1049503 chr15:45653707 T/C cg14582100 chr15:45693742 SPATA5L1 0.29 6.15 0.32 2.27e-9 Homoarginine levels; CRC cis rs6502050 0.777 rs6502058 chr17:80082500 A/C cg02741985 chr17:80059408 CCDC57 -0.44 -7.15 -0.37 5.61e-12 Life satisfaction; CRC cis rs875971 0.660 rs801190 chr7:66033033 C/T cg11764359 chr7:65958608 NA -0.55 -8.63 -0.43 2.66e-16 Aortic root size; CRC cis rs728616 0.681 rs17677908 chr10:82049603 A/G cg11900509 chr10:81946545 ANXA11 -0.56 -6.1 -0.32 2.94e-9 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs72634258 0.842 rs7545745 chr1:8165667 T/A cg26816564 chr1:7831052 VAMP3 -0.52 -6.21 -0.32 1.58e-9 Inflammatory bowel disease; CRC cis rs11623869 0.772 rs12587310 chr14:103907286 G/A cg12935359 chr14:103987150 CKB 0.49 7.6 0.39 3.06e-13 Bone mineral density; CRC cis rs12024301 0.557 rs74981998 chr1:183593829 G/C cg11505048 chr1:183622726 RGL1;APOBEC4 0.74 6.74 0.35 6.91e-11 Peripheral arterial disease (traffic-related air pollution interaction); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg11947960 chr2:112655492 MERTK 0.42 6.02 0.31 4.68e-9 Response to antipsychotic treatment; CRC cis rs9796 0.621 rs2918462 chr15:41481254 A/G cg18705301 chr15:41695430 NDUFAF1 0.43 7.07 0.36 9.62e-12 Menopause (age at onset); CRC cis rs11122272 0.735 rs2246645 chr1:231497393 T/G cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.53 -8.0 -0.4 2.15e-14 Hemoglobin concentration; CRC trans rs6076960 0.652 rs3852945 chr20:6254118 T/C cg21095983 chr6:86352623 SYNCRIP 0.5 7.21 0.37 3.77e-12 Smooth-surface caries; CRC cis rs514406 0.825 rs28817407 chr1:53226116 G/A cg24675658 chr1:53192096 ZYG11B 0.53 7.8 0.39 8.34e-14 Monocyte count; CRC cis rs9462027 0.628 rs9469891 chr6:34767396 A/C cg07306190 chr6:34760872 UHRF1BP1 -0.34 -6.07 -0.32 3.47e-9 Systemic lupus erythematosus; CRC cis rs172166 0.694 rs188105 chr6:28071393 C/T cg12273811 chr6:28175739 NA 0.62 9.07 0.45 1.1e-17 Cardiac Troponin-T levels; CRC trans rs4276421 0.776 rs56908114 chr5:45416794 T/C cg04793272 chr11:119020941 ABCG4 -0.38 -6.35 -0.33 7.18e-10 P wave duration; CRC cis rs2949837 0.581 rs924140 chr7:45963114 C/T cg04727332 chr7:45960243 IGFBP3 0.37 5.91 0.31 8.5e-9 Sitting height ratio; CRC cis rs2386661 0.547 rs11259540 chr10:5646706 A/T cg26603656 chr10:5671107 NA 0.44 7.53 0.38 4.95e-13 Breast cancer; CRC cis rs8060686 0.641 rs75297764 chr16:68212820 C/T cg26727032 chr16:67993705 SLC12A4 -0.53 -6.24 -0.33 1.37e-9 HDL cholesterol;Metabolic syndrome; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg27277367 chr15:100106179 MEF2A -0.43 -6.33 -0.33 8.03e-10 Myopia (pathological); CRC cis rs1448094 0.512 rs11117057 chr12:86248546 C/T cg00310523 chr12:86230176 RASSF9 0.35 5.93 0.31 7.63e-9 Major depressive disorder; CRC cis rs9649213 0.593 rs35983874 chr7:97916461 C/T cg21770322 chr7:97807741 LMTK2 0.54 8.96 0.44 2.43e-17 Prostate cancer (SNP x SNP interaction); CRC cis rs6460942 1.000 rs62448562 chr7:12398785 T/C cg06484146 chr7:12443880 VWDE -0.76 -7.33 -0.37 1.81e-12 Coronary artery disease; CRC cis rs780094 0.544 rs780108 chr2:27684957 T/C cg02592271 chr2:27665507 KRTCAP3 -0.26 -6.06 -0.32 3.77e-9 Calcium levels;Fasting blood insulin;Metabolic traits;Triglyceride levels;Fasting plasma glucose;Urate levels in overweight individuals;Urate levels in obese individuals;Uric acid levels;Height;Age-related diseases, mortality and associated endophenotypes;Renal underexcretion gout;Fasting blood glucose (BMI interaction);Urate levels;Gondoic acid (20:1n-9) levels;Fasting blood insulin (BMI interaction);Triglycerides;Plasma omega-3 polyunsaturated fatty acid levels (docosapentaenoic acid);Type 2 diabetes;Nonalcoholic fatty liver disease;Hypertriglyceridemia;C-reactive protein;Age-related disease endophenotypes;LDL cholesterol;Metabolic syndrome;Crohn's disease;Alcohol consumption (drinks per week);Homeostasis model assessment of insulin resistance;Alcohol consumption;Red blood cell count;Fasting blood glucose; CRC cis rs6570726 0.791 rs11155435 chr6:145938545 T/C cg13319975 chr6:146136371 FBXO30 -0.48 -7.06 -0.36 9.75e-12 Lobe attachment (rater-scored or self-reported); CRC cis rs4888262 0.526 rs4404098 chr16:74570050 G/A cg01733217 chr16:74700730 RFWD3 0.72 10.84 0.51 1.31e-23 Testicular germ cell tumor; CRC cis rs12956009 0.583 rs919979 chr18:44902739 C/T cg19077165 chr18:44547161 KATNAL2 -0.41 -5.91 -0.31 8.49e-9 Educational attainment (years of education); CRC cis rs11948739 0.501 rs3981332 chr5:130372203 A/T cg08523029 chr5:130500466 HINT1 -0.46 -5.98 -0.31 5.75e-9 Pediatric bone mineral content (hip); CRC cis rs9399135 0.967 rs59329760 chr6:135342437 G/A cg22676075 chr6:135203613 NA 0.43 6.72 0.35 7.87e-11 Red blood cell count; CRC cis rs11711311 1.000 rs1043132 chr3:113528689 A/C cg15478005 chr3:113465772 ATP6V1A;NAA50 0.42 5.81 0.3 1.5e-8 IgG glycosylation; CRC cis rs11764590 0.715 rs56289396 chr7:2091415 G/A cg13880726 chr7:1868755 MAD1L1 -0.47 -5.77 -0.3 1.8e-8 Neuroticism; CRC cis rs875971 0.965 rs7794930 chr7:65778546 A/C cg18876405 chr7:65276391 NA -0.52 -8.82 -0.44 6.68e-17 Aortic root size; CRC cis rs7552404 0.924 rs1313071 chr1:76195542 C/G cg10523679 chr1:76189770 ACADM 0.78 11.94 0.55 1.54e-27 Blood metabolite levels;Acylcarnitine levels; CRC cis rs6460942 1.000 rs17274870 chr7:12406221 G/T cg06484146 chr7:12443880 VWDE -0.75 -7.81 -0.4 7.94e-14 Coronary artery disease; CRC cis rs12900413 0.687 rs12913572 chr15:90319313 T/C cg24249390 chr15:90295951 MESP1 -0.6 -9.49 -0.46 4.94e-19 Coronary artery aneurysm in Kawasaki disease; CRC cis rs7301826 0.627 rs73162873 chr12:131296013 A/G cg11011512 chr12:131303247 STX2 0.37 5.62 0.3 4.1e-8 Plasma plasminogen activator levels; CRC trans rs12478296 0.901 rs73007142 chr2:243010852 T/C cg18288967 chr1:45987694 PRDX1 0.66 6.54 0.34 2.38e-10 Obesity-related traits; CRC cis rs9311474 0.607 rs4234633 chr3:52557038 C/T cg18099408 chr3:52552593 STAB1 -0.51 -8.8 -0.44 8.1e-17 Electroencephalogram traits; CRC cis rs637571 0.522 rs3016868 chr11:65764383 C/T cg17985854 chr11:65770987 BANF1;EIF1AD 0.53 9.04 0.45 1.39e-17 Eosinophil percentage of white cells; CRC cis rs35146811 0.735 rs1727138 chr7:99815247 A/G cg13334819 chr7:99746414 C7orf59 0.52 6.8 0.35 4.98e-11 Coronary artery disease; CRC trans rs3733585 0.781 rs6449183 chr4:9970691 C/A cg26043149 chr18:55253948 FECH -0.52 -8.07 -0.41 1.33e-14 Cleft plate (environmental tobacco smoke interaction); CRC cis rs561341 0.609 rs2051810 chr17:30195841 C/T cg00745463 chr17:30367425 LRRC37B 0.53 6.62 0.34 1.49e-10 Hip circumference adjusted for BMI; CRC cis rs798554 1.000 rs798559 chr7:2758341 T/C cg13628971 chr7:2884303 GNA12 0.47 6.47 0.34 3.58e-10 Height; CRC cis rs6938 0.618 rs11857695 chr15:75165751 G/T cg18612461 chr15:75251733 NA 0.37 5.85 0.31 1.21e-8 Breast cancer; CRC trans rs1864585 0.552 rs73208794 chr8:10681248 C/G cg26278703 chr11:58910052 FAM111A 0.56 6.55 0.34 2.24e-10 Neutrophil percentage of white cells;Lymphocyte percentage of white cells; CRC cis rs1178968 0.901 rs7779909 chr7:72751966 G/T cg25889504 chr7:72793014 NA 0.51 5.87 0.31 1.08e-8 Triglyceride levels; CRC cis rs4920343 0.890 rs4920531 chr1:19095746 A/G cg26220594 chr1:19110978 NA -0.41 -6.41 -0.33 5.04e-10 Knee osteoarthritis; CRC cis rs34779708 0.966 rs11010095 chr10:35395948 A/G cg03585969 chr10:35415529 CREM 0.58 7.84 0.4 6.13e-14 Inflammatory bowel disease;Crohn's disease; CRC trans rs10504229 1.000 rs67039591 chr8:58174553 T/A cg04077850 chr5:125800366 GRAMD3 0.37 6.27 0.33 1.15e-9 Developmental language disorder (linguistic errors); CRC cis rs9419702 0.568 rs9419635 chr10:133546164 C/T cg04492858 chr10:133558786 NA 0.39 6.48 0.34 3.34e-10 Survival in rectal cancer; CRC cis rs16852403 0.548 rs615226 chr1:178194524 A/G cg00404053 chr1:178313656 RASAL2 0.48 6.25 0.33 1.27e-9 Childhood ear infection; CRC cis rs4908768 0.501 rs1463050 chr1:8597042 G/A cg20416874 chr1:8611966 RERE -0.46 -6.64 -0.34 1.32e-10 Neuroticism (multi-trait analysis);Subjective well-being (multi-trait analysis); CRC cis rs4076764 0.914 rs6704467 chr1:163364512 A/G cg24596788 chr1:163392923 NA -0.64 -10.21 -0.49 1.97e-21 Motion sickness; CRC cis rs9359856 0.872 rs9344948 chr6:90308226 T/G cg13799429 chr6:90582589 CASP8AP2 0.43 6.06 0.32 3.63e-9 Bipolar disorder; CRC cis rs2882667 0.858 rs11959803 chr5:138451315 G/A cg04439458 chr5:138467593 SIL1 -0.36 -6.0 -0.31 5.08e-9 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs1552244 0.882 rs68153882 chr3:10013110 T/C cg16606324 chr3:10149918 C3orf24 0.62 8.02 0.4 1.87e-14 Alzheimer's disease; CRC cis rs561341 0.882 rs111484028 chr17:30287701 G/A cg12193833 chr17:30244370 NA -0.62 -7.94 -0.4 3.33e-14 Hip circumference adjusted for BMI; CRC cis rs875971 0.545 rs73142265 chr7:65699497 G/A cg11764359 chr7:65958608 NA 0.45 5.65 0.3 3.53e-8 Aortic root size; CRC cis rs9916302 0.904 rs4357971 chr17:37717280 C/T cg07936489 chr17:37558343 FBXL20 -0.86 -13.75 -0.6 2.73e-34 Glomerular filtration rate (creatinine); CRC cis rs62244186 0.541 rs62244226 chr3:44831831 G/A cg11003573 chr3:44754125 ZNF502 -0.33 -5.64 -0.3 3.67e-8 Depressive symptoms; CRC cis rs2404602 1.000 rs12441433 chr15:76816015 G/A cg03037974 chr15:76606532 NA 0.56 9.24 0.45 3.11e-18 Blood metabolite levels; CRC trans rs1814175 0.781 rs1851872 chr11:50009770 A/G cg11707556 chr5:10655725 ANKRD33B -0.43 -8.45 -0.42 9.43e-16 Height; CRC cis rs6831352 0.819 rs896992 chr4:100002372 C/T cg12011299 chr4:100065546 ADH4 0.48 9.6 0.47 2.17e-19 Alcohol dependence; CRC cis rs9467711 0.606 rs13212985 chr6:26609989 G/C cg08501292 chr6:25962987 TRIM38 0.88 6.11 0.32 2.84e-9 Autism spectrum disorder or schizophrenia; CRC cis rs7044106 0.791 rs735110 chr9:123488940 T/A cg14255062 chr9:123606675 PSMD5;LOC253039 0.46 6.77 0.35 5.93e-11 Hip circumference adjusted for BMI; CRC cis rs17428076 0.514 rs3821095 chr2:172684006 A/G cg13550731 chr2:172543902 DYNC1I2 -0.58 -8.01 -0.4 1.95e-14 Myopia; CRC cis rs7605827 0.930 rs10189180 chr2:15685949 T/C cg19274914 chr2:15703543 NA 0.39 5.82 0.31 1.4e-8 Educational attainment (years of education); CRC cis rs35146811 0.883 rs4134903 chr7:99711040 G/A cg03265037 chr7:99691720 MIR25;MCM7;MIR106B;MIR93 0.43 5.63 0.3 3.95e-8 Coronary artery disease; CRC cis rs13108904 0.870 rs4493483 chr4:1279916 G/A cg02018176 chr4:1364513 KIAA1530 0.48 7.84 0.4 6.25e-14 Obesity-related traits; CRC cis rs11190604 1.000 rs75063298 chr10:102213600 C/A cg07570687 chr10:102243282 WNT8B 0.44 5.66 0.3 3.36e-8 Palmitoleic acid (16:1n-7) levels; CRC cis rs11191205 0.644 rs12354716 chr10:103386775 C/A cg15320455 chr10:103880129 LDB1 0.54 6.01 0.31 5.02e-9 Intelligence (multi-trait analysis); CRC cis rs1707322 1.000 rs10890372 chr1:46391020 T/G cg03146154 chr1:46216737 IPP 0.5 7.04 0.36 1.12e-11 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs4862750 0.624 rs34414639 chr4:187873417 C/A cg03647317 chr4:187891568 NA -0.55 -10.13 -0.49 3.48e-21 Lobe attachment (rater-scored or self-reported); CRC cis rs11252926 0.673 rs10795161 chr10:497748 G/T cg16386425 chr10:429943 DIP2C -0.41 -6.08 -0.32 3.36e-9 Psychosis in Alzheimer's disease; CRC cis rs950169 1.000 rs12902672 chr15:84716986 G/A cg24253500 chr15:84953950 NA 0.37 6.26 0.33 1.18e-9 Schizophrenia; CRC cis rs755249 0.567 rs905381 chr1:39688552 T/G cg18385671 chr1:39797026 MACF1 -0.43 -6.13 -0.32 2.48e-9 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs35306767 0.761 rs11253540 chr10:1011958 C/T cg26597838 chr10:835615 NA -0.9 -10.67 -0.51 4.95e-23 Eosinophil percentage of granulocytes; CRC cis rs7666738 0.830 rs7678567 chr4:99057346 A/G cg05340658 chr4:99064831 C4orf37 0.61 9.43 0.46 7.4e-19 Colonoscopy-negative controls vs population controls; CRC trans rs9467711 1.000 rs6939799 chr6:26328366 G/A cg15845792 chr6:28175446 NA 0.66 6.3 0.33 9.77e-10 Autism spectrum disorder or schizophrenia; CRC cis rs1799949 0.965 rs1842147 chr17:41435192 C/T cg19454999 chr17:41278357 BRCA1;NBR2 0.52 7.98 0.4 2.38e-14 Menopause (age at onset); CRC cis rs1355223 0.583 rs1396880 chr11:34870552 C/T cg11058730 chr11:34937778 PDHX;APIP -0.71 -11.56 -0.54 3.75e-26 Systemic lupus erythematosus and Systemic sclerosis; CRC cis rs972578 1.000 rs4822247 chr22:43403290 C/T cg01576275 chr22:43409880 NA -0.51 -8.38 -0.42 1.53e-15 Mean platelet volume; CRC cis rs10540 1.000 rs61876341 chr11:495892 C/G cg03934478 chr11:495069 RNH1 0.69 7.73 0.39 1.28e-13 Body mass index; CRC cis rs1865760 0.566 rs3752419 chr6:26027433 C/T cg16482183 chr6:26056742 HIST1H1C 0.55 7.98 0.4 2.46e-14 Height; CRC cis rs6951245 0.872 rs113119264 chr7:1080564 G/A cg21664854 chr7:1097933 C7orf50;GPR146 0.79 8.94 0.44 2.89e-17 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs9399135 0.933 rs41294852 chr6:135376379 T/G cg24558204 chr6:135376177 HBS1L 0.49 7.69 0.39 1.68e-13 Red blood cell count; CRC cis rs12701220 0.894 rs34712249 chr7:1036634 C/T cg26240231 chr7:1148101 C7orf50 -0.44 -6.06 -0.32 3.83e-9 Bronchopulmonary dysplasia; CRC cis rs2075371 0.932 rs2241333 chr7:133970750 C/T cg11752832 chr7:134001865 SLC35B4 0.48 7.56 0.38 3.98e-13 Mean platelet volume; CRC cis rs2228479 0.850 rs1800339 chr16:89839637 C/A cg06558623 chr16:89946397 TCF25 1.13 10.76 0.51 2.47e-23 Skin colour saturation; CRC trans rs4942242 0.640 rs9533571 chr13:44230136 C/T cg26741380 chr15:41871084 TYRO3 -0.46 -6.83 -0.35 4.23e-11 Response to tocilizumab in rheumatoid arthritis; CRC cis rs1506636 1.000 rs689341 chr7:123403974 C/A cg03229431 chr7:123269106 ASB15 0.73 11.69 0.54 1.23e-26 Plateletcrit;Platelet count; CRC cis rs8105895 0.877 rs2163837 chr19:22242236 G/A cg02657401 chr19:22469223 NA -0.34 -5.65 -0.3 3.56e-8 Body mass index (change over time); CRC cis rs12908161 1.000 rs12912388 chr15:85344550 T/A cg17507749 chr15:85114479 UBE2QP1 0.6 8.56 0.43 4.26e-16 Schizophrenia; CRC cis rs780096 0.526 rs704795 chr2:27716494 G/A cg12648201 chr2:27665141 KRTCAP3 -0.3 -6.07 -0.32 3.49e-9 Total body bone mineral density; CRC cis rs1223397 0.651 rs2496147 chr6:13313233 C/T cg20827128 chr6:13274284 PHACTR1 0.37 5.74 0.3 2.18e-8 Blood pressure; CRC cis rs2976388 0.566 rs13250661 chr8:143804134 C/T cg12516270 chr8:143859308 LYNX1 -0.42 -6.95 -0.36 1.96e-11 Urinary tract infection frequency; CRC trans rs66573146 0.831 rs56031152 chr4:6973832 C/A cg07817883 chr1:32538562 TMEM39B 1.35 12.74 0.57 1.69e-30 Granulocyte percentage of myeloid white cells; CRC cis rs9916302 0.851 rs12947620 chr17:37605364 T/C cg15445000 chr17:37608096 MED1 0.43 9.47 0.46 5.76e-19 Glomerular filtration rate (creatinine); CRC cis rs3889199 0.707 rs10493256 chr1:59688948 A/G cg25881383 chr1:59680599 NA 0.37 6.1 0.32 2.99e-9 Pulse pressure; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg01717948 chr16:30709586 SRCAP 0.48 6.54 0.34 2.32e-10 Anxiety disorder; CRC cis rs2645694 0.626 rs2645709 chr4:77824474 G/A cg10057126 chr4:77819792 ANKRD56 0.34 5.82 0.31 1.39e-8 Emphysema distribution in smoking; CRC trans rs1941687 0.526 rs9959347 chr18:31316169 C/T cg27147174 chr7:100797783 AP1S1 -0.37 -6.35 -0.33 7.32e-10 Subjective well-being (multi-trait analysis);Subjective well-being; CRC trans rs12517041 1.000 rs2081954 chr5:23295705 G/C ch.8.1293020R chr8:59333349 UBXN2B -0.54 -6.08 -0.32 3.3e-9 Calcium levels; CRC cis rs2276314 0.857 rs28791905 chr18:33602213 G/A cg05985134 chr18:33552581 C18orf21 0.45 5.88 0.31 1.03e-8 Endometriosis;Drug-induced torsades de pointes; CRC cis rs4975616 0.836 rs421629 chr5:1320136 G/A cg26373071 chr5:1325741 CLPTM1L 0.55 9.84 0.48 3.38e-20 Lung cancer; CRC cis rs7119 0.679 rs12914932 chr15:77839051 G/A cg10437265 chr15:77819839 NA 0.66 11.62 0.54 2.13e-26 Type 2 diabetes; CRC cis rs7044106 0.762 rs10818471 chr9:123394045 A/G cg09586646 chr9:123605570 PSMD5;LOC253039 0.64 8.98 0.44 2.1e-17 Hip circumference adjusted for BMI; CRC trans rs11148252 0.846 rs13431 chr13:52987477 G/C cg18335740 chr13:41363409 SLC25A15 0.54 8.26 0.41 3.51e-15 Lewy body disease; CRC cis rs7119 0.604 rs2682921 chr15:77865459 C/T cg27398640 chr15:77910606 LINGO1 0.45 7.72 0.39 1.45e-13 Type 2 diabetes; CRC cis rs7552404 0.960 rs4949877 chr1:76201668 C/G cg03433033 chr1:76189801 ACADM 0.79 10.76 0.51 2.39e-23 Blood metabolite levels;Acylcarnitine levels; CRC cis rs798766 0.903 rs798726 chr4:1685211 C/T cg05874882 chr4:1763078 NA 0.33 5.9 0.31 8.99e-9 Bladder cancer;Urinary bladder cancer; CRC cis rs6951245 0.572 rs79396168 chr7:1048928 C/T cg24642844 chr7:1081250 C7orf50 -0.9 -7.57 -0.38 3.91e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs2404618 0.587 rs6994849 chr8:1492839 G/T cg13402656 chr8:1511478 DLGAP2 0.68 10.85 0.51 1.18e-23 Lung cancer; CRC cis rs1707322 0.691 rs11211175 chr1:46220884 C/G cg06784218 chr1:46089804 CCDC17 0.58 10.52 0.5 1.69e-22 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs17253792 0.545 rs34446601 chr14:56010586 A/G cg01858014 chr14:56050164 KTN1 -0.83 -6.74 -0.35 7.07e-11 Putamen volume; CRC cis rs9814567 1.000 rs7429866 chr3:134236306 C/T cg06109529 chr3:134205091 CEP63;ANAPC13 0.82 12.09 0.55 4.21e-28 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs1559088 0.948 rs12610071 chr19:33582687 A/C cg27124370 chr19:33622961 WDR88 0.44 6.13 0.32 2.53e-9 Bone ultrasound measurement (broadband ultrasound attenuation); CRC cis rs1865760 0.613 rs9379801 chr6:25901711 T/C cg16482183 chr6:26056742 HIST1H1C 0.41 6.07 0.32 3.62e-9 Height; CRC cis rs514406 0.861 rs7518390 chr1:53233374 A/G cg27535305 chr1:53392650 SCP2 0.39 7.0 0.36 1.42e-11 Monocyte count; CRC cis rs951366 0.789 rs823097 chr1:205681370 G/A cg14893161 chr1:205819251 PM20D1 0.82 12.51 0.57 1.22e-29 Menarche (age at onset); CRC cis rs7829975 0.560 rs17154599 chr8:8551418 C/T cg06636001 chr8:8085503 FLJ10661 -0.41 -6.06 -0.32 3.67e-9 Mood instability; CRC cis rs11098499 1.000 rs13435802 chr4:120177960 A/T cg24375607 chr4:120327624 NA -0.45 -6.92 -0.36 2.43e-11 Corneal astigmatism; CRC cis rs35306767 0.903 rs11813210 chr10:919796 G/A cg26597838 chr10:835615 NA 0.97 12.04 0.55 6.75e-28 Eosinophil percentage of granulocytes; CRC cis rs7259376 0.936 rs12459636 chr19:22542439 C/T cg02657401 chr19:22469223 NA 0.33 7.42 0.38 9.91e-13 Menopause (age at onset); CRC cis rs79387448 0.935 rs7567133 chr2:103253128 C/A cg09003973 chr2:102972529 NA 0.59 6.67 0.34 1.11e-10 Gut microbiota (bacterial taxa); CRC cis rs853679 0.517 rs1904840 chr6:28108232 C/T cg15845792 chr6:28175446 NA 1.04 13.89 0.61 7.67e-35 Depression; CRC cis rs8072100 0.967 rs3760370 chr17:45695832 C/T cg25173405 chr17:45401733 C17orf57 0.43 6.58 0.34 1.91e-10 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs73206853 0.640 rs2098140 chr12:110726081 T/A cg12870014 chr12:110450643 ANKRD13A 0.78 8.2 0.41 5.55e-15 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC cis rs6499255 1.000 rs4985523 chr16:69797192 T/A cg00738113 chr16:70207722 CLEC18C -0.4 -5.7 -0.3 2.63e-8 IgE levels; CRC cis rs2073300 0.609 rs6137939 chr20:23390206 C/T cg12062639 chr20:23401060 NAPB -0.68 -6.49 -0.34 3.07e-10 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs2204008 0.811 rs8189445 chr12:38276295 T/C cg13010199 chr12:38710504 ALG10B 0.44 5.73 0.3 2.33e-8 Bladder cancer; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg01883208 chr1:233316809 PCNXL2 -0.39 -6.05 -0.32 3.89e-9 Liver disease severity in Alagille syndrome; CRC trans rs12599106 0.770 rs12445057 chr16:34970274 C/G cg01516881 chr6:292596 DUSP22 -0.64 -9.26 -0.45 2.78e-18 Menopause (age at onset); CRC cis rs2160860 0.773 rs11779700 chr8:39797778 C/T cg11363097 chr8:39792086 IDO2 -0.43 -7.26 -0.37 2.77e-12 Blood metabolite levels; CRC cis rs10504229 0.593 rs11781042 chr8:57993056 A/T cg22535103 chr8:58192502 C8orf71 -0.49 -5.6 -0.3 4.49e-8 Developmental language disorder (linguistic errors); CRC cis rs12980942 0.810 rs35812313 chr19:41789178 T/C cg25627403 chr19:41769009 HNRNPUL1 0.52 5.96 0.31 6.4e-9 Coronary artery disease; CRC cis rs7107174 1.000 rs10793311 chr11:78104399 G/C cg02023728 chr11:77925099 USP35 0.47 7.25 0.37 2.92e-12 Testicular germ cell tumor; CRC cis rs514406 0.861 rs12038438 chr1:53230581 A/T cg24675658 chr1:53192096 ZYG11B 0.53 7.67 0.39 1.97e-13 Monocyte count; CRC cis rs10504229 0.683 rs56204590 chr8:58131642 T/G cg04204079 chr8:58130323 NA -0.45 -5.78 -0.3 1.71e-8 Developmental language disorder (linguistic errors); CRC cis rs9311676 0.656 rs6445977 chr3:58379560 T/C cg06643156 chr3:58380774 PXK 0.41 6.33 0.33 7.92e-10 Systemic lupus erythematosus; CRC cis rs10256972 0.577 rs4999286 chr7:1199506 C/G cg18402987 chr7:1209562 NA 0.58 8.91 0.44 3.66e-17 Longevity;Endometriosis; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg01213445 chr15:91537450 PRC1 0.37 6.29 0.33 1.02e-9 Liver disease severity in Alagille syndrome; CRC cis rs651907 0.557 rs36002990 chr3:101437862 G/A cg11279151 chr3:101281821 RG9MTD1 -0.54 -7.4 -0.38 1.12e-12 Colorectal cancer; CRC cis rs6952808 0.656 rs11764212 chr7:2067593 C/A cg02951883 chr7:2050386 MAD1L1 -0.76 -11.77 -0.54 6.06e-27 Bipolar disorder and schizophrenia; CRC cis rs11122272 0.735 rs2011357 chr1:231480208 A/G cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.52 -7.6 -0.39 3.12e-13 Hemoglobin concentration; CRC cis rs6565180 1.000 rs11646130 chr16:30376959 T/C cg01392867 chr16:30410429 ZNF48 -0.36 -5.71 -0.3 2.53e-8 Tonsillectomy; CRC cis rs9322193 0.884 rs12528279 chr6:150072028 A/C cg07701084 chr6:150067640 NUP43 0.59 8.71 0.43 1.48e-16 Lung cancer; CRC cis rs897984 0.542 rs8061047 chr16:31068960 T/C cg00531865 chr16:30841666 NA -0.4 -5.68 -0.3 2.93e-8 Dementia with Lewy bodies; CRC cis rs7119 0.623 rs12905318 chr15:77845873 T/C cg10437265 chr15:77819839 NA 0.59 9.99 0.48 1.03e-20 Type 2 diabetes; CRC trans rs10411161 0.935 rs8107422 chr19:52368775 C/A cg22319618 chr22:45562946 NUP50 -0.52 -6.15 -0.32 2.23e-9 Breast cancer; CRC cis rs7647973 0.731 rs13084037 chr3:49214066 G/A cg20833759 chr3:49053208 WDR6;DALRD3 0.5 6.8 0.35 4.95e-11 Menarche (age at onset); CRC cis rs17270561 0.697 rs9366633 chr6:25838054 A/G cg16482183 chr6:26056742 HIST1H1C 0.71 9.47 0.46 5.73e-19 Iron status biomarkers; CRC cis rs11574514 1.000 rs16957524 chr16:67798005 A/G cg26727032 chr16:67993705 SLC12A4 -0.66 -6.43 -0.33 4.56e-10 Crohn's disease; CRC cis rs17767294 0.612 rs9461424 chr6:27919401 G/A cg06470822 chr6:28175283 NA 0.82 8.39 0.42 1.49e-15 Parkinson's disease; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg11871820 chr6:131949485 MED23 -0.41 -5.99 -0.31 5.51e-9 Myopia (pathological); CRC cis rs9311676 0.656 rs9881869 chr3:58333255 G/A cg06643156 chr3:58380774 PXK -0.44 -6.8 -0.35 4.99e-11 Systemic lupus erythematosus; CRC trans rs61101201 0.962 rs10835790 chr11:31610022 C/T cg10766172 chr7:27498479 NA -0.51 -6.01 -0.31 4.82e-9 Optic disc area; CRC cis rs801193 1.000 rs4717310 chr7:66161007 C/T cg05627663 chr7:65219948 SNORA22;CCT6P1 0.42 6.13 0.32 2.46e-9 Aortic root size; CRC cis rs951366 1.000 rs4951261 chr1:205717823 A/C cg26354017 chr1:205819088 PM20D1 -0.4 -5.82 -0.31 1.36e-8 Menarche (age at onset); CRC cis rs6951245 0.938 rs117729148 chr7:1108531 G/A cg04025307 chr7:1156635 C7orf50 0.66 7.09 0.36 8.05e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs8072100 0.967 rs4239162 chr17:45755810 G/A cg25173405 chr17:45401733 C17orf57 -0.45 -6.95 -0.36 2.01e-11 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs9549328 0.800 rs9549326 chr13:113630453 C/T cg24588162 chr13:113633484 MCF2L -0.43 -7.64 -0.39 2.4e-13 Systolic blood pressure; CRC cis rs2797160 1.000 rs1832979 chr6:125997436 A/G cg05901451 chr6:126070800 HEY2 -0.43 -6.57 -0.34 1.98e-10 Endometrial cancer; CRC cis rs9372498 0.536 rs62424172 chr6:118777533 C/A cg07617317 chr6:118971624 C6orf204 0.52 6.4 0.33 5.29e-10 Diastolic blood pressure; CRC cis rs10979 0.782 rs9390108 chr6:143892722 A/T cg25407410 chr6:143891975 LOC285740 -0.82 -13.0 -0.58 1.88e-31 Hypospadias; CRC trans rs10506458 0.915 rs12426017 chr12:63396272 T/G cg03429785 chr15:59498649 MYO1E;LDHAL6B -1.43 -21.47 -0.76 1.48e-64 Hemostatic factors and hematological phenotypes; CRC cis rs208520 0.821 rs9363572 chr6:67012231 C/T cg07460842 chr6:66804631 NA 0.84 9.91 0.48 1.91e-20 Exhaled nitric oxide output; CRC cis rs644799 0.526 rs530914 chr11:95632156 C/T cg25622487 chr11:95524042 FAM76B;CEP57 0.5 7.39 0.38 1.2e-12 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs9467773 0.620 rs6925087 chr6:26592853 T/A cg09904177 chr6:26538194 HMGN4 0.73 11.54 0.54 4.38e-26 Intelligence (multi-trait analysis); CRC cis rs6540556 0.954 rs654984 chr1:209937382 C/T cg23920097 chr1:209922102 NA 0.51 6.51 0.34 2.78e-10 Red blood cell count; CRC cis rs6951245 1.000 rs77083167 chr7:1071823 C/T cg24642844 chr7:1081250 C7orf50 -0.78 -9.35 -0.46 1.42e-18 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs3820068 0.705 rs11577225 chr1:15864242 T/C cg27534772 chr1:16042836 PLEKHM2 0.44 7.44 0.38 8.59e-13 Systolic blood pressure; CRC trans rs1814175 0.817 rs11040474 chr11:49708441 G/A cg03929089 chr4:120376271 NA -0.97 -18.83 -0.72 3.58e-54 Height; CRC cis rs12620999 0.938 rs4575672 chr2:238070572 T/C cg23555395 chr2:238036564 NA -0.62 -9.94 -0.48 1.59e-20 Systemic lupus erythematosus; CRC cis rs2180341 0.782 rs6912750 chr6:127723081 A/T cg24812749 chr6:127587940 RNF146 0.68 9.21 0.45 4.07e-18 Breast cancer; CRC cis rs8141529 0.748 rs132531 chr22:29297365 C/T cg02153584 chr22:29168773 CCDC117 -0.47 -6.74 -0.35 7.27e-11 Lymphocyte counts; CRC cis rs11122272 0.701 rs2790887 chr1:231523724 G/C cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.54 -8.14 -0.41 7.99e-15 Hemoglobin concentration; CRC cis rs7618915 0.547 rs2878726 chr3:52748271 C/G cg18099408 chr3:52552593 STAB1 -0.44 -7.2 -0.37 4.11e-12 Bipolar disorder; CRC cis rs7927771 0.524 rs7107922 chr11:47669289 C/A cg20307385 chr11:47447363 PSMC3 0.46 6.88 0.35 2.94e-11 Subjective well-being; CRC cis rs2652834 0.950 rs2729787 chr15:63401493 G/T cg05507819 chr15:63340323 TPM1 0.45 5.72 0.3 2.35e-8 HDL cholesterol; CRC cis rs7584330 0.826 rs72620825 chr2:238381243 G/A cg14458575 chr2:238380390 NA 0.88 15.52 0.65 3.72e-41 Prostate cancer; CRC cis rs1005224 1.000 rs1005224 chr14:76173860 A/T cg04684003 chr14:76127793 TTLL5;C14orf1 -0.46 -6.66 -0.34 1.17e-10 Large artery stroke; CRC cis rs853679 0.517 rs17711801 chr6:28092307 C/G cg02683197 chr6:28174875 NA 0.85 10.52 0.5 1.71e-22 Depression; CRC cis rs10791097 0.694 rs2155750 chr11:130751261 A/C cg12179176 chr11:130786555 SNX19 0.75 12.6 0.57 5.52e-30 Autism spectrum disorder or schizophrenia;Schizophrenia; CRC cis rs2832191 1.000 rs6516891 chr21:30483070 C/T cg08807101 chr21:30365312 RNF160 -0.61 -9.95 -0.48 1.47e-20 Dental caries; CRC cis rs1580019 0.563 rs13244332 chr7:32537679 G/A cg07520158 chr7:32535189 LSM5;AVL9 0.55 8.14 0.41 8.33e-15 Cognitive ability; CRC cis rs61160187 0.517 rs6884966 chr5:60193339 T/C cg16298547 chr5:60138761 ELOVL7 -0.28 -5.93 -0.31 7.59e-9 Educational attainment (years of education);Educational attainment (college completion); CRC trans rs11026407 0.967 rs7127246 chr11:22060228 C/G cg05608388 chr19:18794257 CRTC1 -0.57 -6.02 -0.31 4.78e-9 Plasma thyroid-stimulating hormone levels; CRC cis rs10504229 0.861 rs6990617 chr8:58182960 G/T cg22535103 chr8:58192502 C8orf71 -0.82 -12.27 -0.56 9.63e-29 Developmental language disorder (linguistic errors); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg23222573 chr20:13765663 ESF1;C20orf7 0.46 6.85 0.35 3.6e-11 Intelligence (multi-trait analysis); CRC cis rs2462686 1.000 rs809298 chr7:45998344 C/A cg23193639 chr7:45961078 IGFBP3 -0.38 -5.86 -0.31 1.14e-8 Major depressive disorder; CRC trans rs2727020 0.729 rs1917325 chr11:49370004 G/A cg15704280 chr7:45808275 SEPT13 -0.89 -16.29 -0.67 3.52e-44 Coronary artery disease; CRC cis rs6964587 0.967 rs10280620 chr7:91582183 C/G cg17063962 chr7:91808500 NA -0.79 -13.8 -0.61 1.73e-34 Breast cancer; CRC trans rs1005277 0.579 rs1780136 chr10:38501453 A/G cg11292332 chr7:45801988 SEPT13 -0.38 -7.02 -0.36 1.26e-11 Extrinsic epigenetic age acceleration; CRC cis rs6502050 0.835 rs35192339 chr17:80119106 G/A cg02741985 chr17:80059408 CCDC57 0.43 7.15 0.37 5.59e-12 Life satisfaction; CRC cis rs10504229 0.683 rs67035623 chr8:58139963 G/T cg02725872 chr8:58115012 NA -0.64 -11.55 -0.54 3.85e-26 Developmental language disorder (linguistic errors); CRC cis rs17443541 0.507 rs2122535 chr2:200456289 G/A cg03741458 chr2:200468445 NA -0.36 -5.71 -0.3 2.49e-8 Intelligence (multi-trait analysis); CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg13746315 chr15:94774850 NA 0.47 6.51 0.34 2.87e-10 Anxiety disorder; CRC cis rs1865760 0.566 rs2858993 chr6:26087856 T/A cg17691542 chr6:26056736 HIST1H1C 0.53 7.95 0.4 3.05e-14 Height; CRC cis rs13108904 0.870 rs4974542 chr4:1250908 A/G cg20092199 chr4:1342459 KIAA1530 0.34 5.9 0.31 8.88e-9 Obesity-related traits; CRC cis rs898097 0.783 rs11650335 chr17:80835111 A/G cg19046167 chr17:80928561 B3GNTL1 -0.42 -6.52 -0.34 2.6200000000000003e-10 Breast cancer; CRC cis rs1580019 0.587 rs7806113 chr7:32553084 A/G cg14728415 chr7:32535168 LSM5;AVL9 0.45 6.38 0.33 6.1e-10 Cognitive ability; CRC cis rs7811142 0.775 rs1059129 chr7:99926522 A/G cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.11 16.39 0.67 1.53e-44 Platelet count; CRC cis rs919433 0.680 rs787983 chr2:198345797 C/T cg10820045 chr2:198174542 NA 0.42 7.13 0.37 6.4e-12 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC cis rs7843479 0.601 rs2306645 chr8:21845428 C/T cg17168535 chr8:21777572 XPO7 -0.57 -9.16 -0.45 5.49e-18 Mean corpuscular volume; CRC cis rs1801251 1.000 rs6761324 chr2:233582793 T/G cg25237894 chr2:233734115 C2orf82 0.54 8.72 0.43 1.44e-16 Coronary artery disease; CRC cis rs7086627 0.515 rs11202963 chr10:82210392 A/G cg09626299 chr10:82213104 TSPAN14 -0.37 -6.23 -0.33 1.39e-9 Post bronchodilator FEV1; CRC cis rs2836974 0.545 rs3167757 chr21:40714478 C/T cg17971929 chr21:40555470 PSMG1 0.52 7.39 0.38 1.26e-12 Cognitive function; CRC cis rs6685188 0.920 rs10751444 chr1:205662144 A/G cg24503407 chr1:205819492 PM20D1 -0.43 -5.92 -0.31 8e-9 White blood cell count (basophil);Basophil percentage of white cells; CRC cis rs189798 1.000 rs189798 chr8:8990577 A/G cg20515095 chr8:8998461 PPP1R3B 0.42 5.68 0.3 2.99e-8 Myopia (pathological); CRC cis rs2549003 1.000 rs2070728 chr5:131819977 C/T cg02551604 chr5:131831745 NA -0.54 -8.34 -0.42 2e-15 Asthma (sex interaction); CRC cis rs709400 0.628 rs7150317 chr14:103921691 C/G cg12935359 chr14:103987150 CKB -0.48 -7.88 -0.4 4.89e-14 Body mass index; CRC cis rs7552404 0.731 rs61770556 chr1:76421902 T/C cg10523679 chr1:76189770 ACADM 0.74 8.43 0.42 1.07e-15 Blood metabolite levels;Acylcarnitine levels; CRC cis rs10256972 0.758 rs9801444 chr7:1080444 A/C cg02869364 chr7:1081709 C7orf50 0.38 5.93 0.31 7.55e-9 Longevity;Endometriosis; CRC cis rs2836974 0.897 rs35386515 chr21:40532047 C/T cg11644478 chr21:40555479 PSMG1 0.8 12.62 0.57 4.88e-30 Cognitive function; CRC trans rs800082 0.516 rs6765790 chr3:144225908 A/G cg24215973 chr2:240111563 HDAC4 0.48 6.65 0.34 1.26e-10 Smoking behavior; CRC cis rs9894429 1.000 rs7209180 chr17:79581519 C/A cg18240062 chr17:79603768 NPLOC4 0.56 9.34 0.46 1.54e-18 Eye color traits; CRC cis rs2243480 1.000 rs160644 chr7:65558186 C/T cg18252515 chr7:66147081 NA -1.13 -13.64 -0.6 6.76e-34 Diabetic kidney disease; CRC cis rs6598955 0.671 rs12129482 chr1:26623641 C/T cg00852783 chr1:26633632 UBXN11 -0.47 -5.67 -0.3 3.09e-8 Obesity-related traits; CRC cis rs9388451 0.839 rs4897157 chr6:126102981 A/T cg10911889 chr6:126070802 HEY2 0.39 5.92 0.31 7.99e-9 Brugada syndrome; CRC cis rs17023223 0.537 rs66715579 chr1:119725432 G/A cg05756136 chr1:119680316 WARS2 -0.52 -7.14 -0.37 6e-12 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for BMI in active individuals; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg04432606 chr2:179315409 PRKRA;MIR548N;DFNB59 0.44 6.2 0.32 1.69e-9 Response to antipsychotic treatment; CRC cis rs6502050 0.835 rs7221451 chr17:80089785 A/G cg25804541 chr17:80189381 SLC16A3 -0.32 -6.04 -0.32 4.11e-9 Life satisfaction; CRC cis rs11122272 0.701 rs2486725 chr1:231540288 G/C cg06096015 chr1:231504339 EGLN1 0.41 6.17 0.32 1.97e-9 Hemoglobin concentration; CRC cis rs6952808 0.792 rs12536261 chr7:1953571 G/A cg22963979 chr7:1858916 MAD1L1 -0.53 -7.84 -0.4 6.18e-14 Bipolar disorder and schizophrenia; CRC cis rs908922 0.676 rs4845784 chr1:152494583 G/C cg09873164 chr1:152488093 CRCT1 0.39 6.49 0.34 3.08e-10 Hair morphology; CRC cis rs10504229 1.000 rs73609760 chr8:58192170 A/G cg22535103 chr8:58192502 C8orf71 -0.83 -12.26 -0.56 1.03e-28 Developmental language disorder (linguistic errors); CRC cis rs2019137 0.868 rs6755639 chr2:113981810 A/G cg07772999 chr2:113993052 PAX8;LOC440839;LOC654433 0.44 6.29 0.33 1e-9 Lymphocyte counts; CRC trans rs4263408 0.934 rs9683743 chr4:39703194 A/C cg20989729 chr11:101981056 YAP1 -0.41 -6.24 -0.33 1.32e-9 Plasma amyloid beta peptide concentrations (ABx-40); CRC cis rs2067615 0.524 rs9971765 chr12:107092299 G/A cg13491945 chr12:107078410 RFX4 0.36 6.24 0.33 1.31e-9 Heart rate; CRC cis rs2692947 0.644 rs1168968 chr2:96825363 C/T cg23100626 chr2:96804247 ASTL 0.27 7.18 0.37 4.62e-12 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; CRC cis rs8040855 0.657 rs6496733 chr15:85673176 G/T cg10818794 chr15:86012489 AKAP13 0.42 5.61 0.3 4.38e-8 Bulimia nervosa; CRC cis rs6840360 0.571 rs62327269 chr4:152527973 G/C cg09659197 chr4:152720779 NA 0.31 5.64 0.3 3.67e-8 Intelligence (multi-trait analysis); CRC cis rs2952156 1.000 rs2952156 chr17:37876835 A/G cg20243544 chr17:37824526 PNMT 0.53 7.92 0.4 3.66e-14 Asthma; CRC cis rs7727544 0.507 rs10051679 chr5:131570931 T/A cg12564285 chr5:131593104 PDLIM4 0.53 9.87 0.48 2.64e-20 Blood metabolite levels; CRC cis rs7666738 0.715 rs3857216 chr4:99032129 G/T cg17366294 chr4:99064904 C4orf37 0.44 7.48 0.38 6.96e-13 Colonoscopy-negative controls vs population controls; CRC cis rs11098699 0.821 rs4833887 chr4:124208033 T/C cg09941581 chr4:124220074 SPATA5 0.4 5.84 0.31 1.25e-8 Mosquito bite size; CRC cis rs2011503 1.000 rs80007081 chr19:19626734 A/G cg11584989 chr19:19387371 SF4 0.57 6.39 0.33 5.7e-10 Bipolar disorder; CRC cis rs736408 0.509 rs1108842 chr3:52720080 A/C cg18099408 chr3:52552593 STAB1 -0.54 -9.78 -0.47 5.42e-20 Bipolar disorder; CRC cis rs10504229 1.000 rs73609762 chr8:58192695 A/G cg24829409 chr8:58192753 C8orf71 -0.68 -11.34 -0.53 2.27e-25 Developmental language disorder (linguistic errors); CRC cis rs10504229 1.000 rs17216620 chr8:58169412 A/G cg22535103 chr8:58192502 C8orf71 -0.8 -12.19 -0.56 1.9e-28 Developmental language disorder (linguistic errors); CRC cis rs6429082 0.783 rs291385 chr1:235646613 T/C cg26050004 chr1:235667680 B3GALNT2 0.59 8.1 0.41 1.11e-14 Adiposity; CRC cis rs6867032 0.958 rs4463207 chr5:2017118 G/T cg26168224 chr5:2018326 NA 1.0 18.58 0.72 3.27e-53 Gut microbiome composition (winter); CRC cis rs17125944 0.615 rs12590862 chr14:53297008 A/G cg00686598 chr14:53173677 PSMC6 -0.62 -5.94 -0.31 7.38e-9 Alzheimer's disease (late onset); CRC trans rs6703335 0.870 rs10803142 chr1:243598234 A/G cg02668729 chr1:41445680 CTPS 0.45 6.22 0.32 1.47e-9 Schizophrenia;Schizophrenia, schizoaffective disorder or bipolar disorder; CRC cis rs6582630 0.572 rs1969363 chr12:38514872 A/G cg26384229 chr12:38710491 ALG10B 0.56 8.24 0.41 4.09e-15 Drug-induced liver injury (flucloxacillin); CRC cis rs1559088 0.576 rs4805852 chr19:33609441 C/T cg27124370 chr19:33622961 WDR88 0.47 7.0 0.36 1.44e-11 Bone ultrasound measurement (broadband ultrasound attenuation); CRC cis rs9611565 0.592 rs12484254 chr22:41962003 T/A cg06634786 chr22:41940651 POLR3H -0.52 -6.07 -0.32 3.46e-9 Vitiligo; CRC cis rs11249608 0.789 rs7704963 chr5:178436854 A/G cg01312482 chr5:178451176 ZNF879 -0.35 -6.09 -0.32 3.13e-9 Pubertal anthropometrics; CRC trans rs1814175 0.645 rs7103554 chr11:50027612 G/A cg03929089 chr4:120376271 NA -0.89 -15.86 -0.66 1.84e-42 Height; CRC trans rs4478147 0.636 rs72665746 chr4:87466471 G/C cg01215037 chr19:50083917 PRRG2;NOSIP 0.45 5.97 0.31 6.1e-9 Migraine - clinic-based; CRC trans rs7180079 0.920 rs11071790 chr15:64601979 G/A cg22857141 chr5:123707481 NA 0.48 6.03 0.32 4.52e-9 Monocyte count; CRC cis rs7666738 0.606 rs3846446 chr4:99099768 C/A cg05340658 chr4:99064831 C4orf37 0.48 7.0 0.36 1.48e-11 Colonoscopy-negative controls vs population controls; CRC trans rs11039798 0.507 rs56994343 chr11:48896970 G/A cg03929089 chr4:120376271 NA 0.67 6.8 0.35 4.95e-11 Axial length; CRC cis rs559928 0.606 rs56207008 chr11:63883215 C/T cg19465662 chr11:63993652 NUDT22;TRPT1 0.68 6.27 0.33 1.16e-9 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; CRC cis rs9916302 0.851 rs9909064 chr17:37500434 G/T cg15445000 chr17:37608096 MED1 -0.44 -9.76 -0.47 6.22e-20 Glomerular filtration rate (creatinine); CRC cis rs1005277 0.579 rs2474595 chr10:38426782 C/G cg25517755 chr10:38738941 LOC399744 0.44 6.28 0.33 1.09e-9 Extrinsic epigenetic age acceleration; CRC cis rs9926296 0.744 rs6860 chr16:89711120 C/T cg03605463 chr16:89740564 NA 0.58 8.92 0.44 3.41e-17 Vitiligo; CRC cis rs7680126 0.536 rs3796841 chr4:10007904 C/T cg11266682 chr4:10021025 SLC2A9 0.4 5.73 0.3 2.27e-8 Urate levels in lean individuals;Urate levels in overweight individuals;Urate levels in obese individuals; CRC cis rs2153535 0.601 rs969420 chr6:8451966 T/A cg21535247 chr6:8435926 SLC35B3 0.5 7.45 0.38 8.15e-13 Motion sickness; CRC cis rs9420 0.961 rs2847308 chr11:57498232 C/T cg23127183 chr11:57508653 C11orf31 0.53 7.43 0.38 9.34e-13 Schizophrenia; CRC cis rs7633770 0.749 rs6442011 chr3:46685722 C/T cg11219411 chr3:46661640 NA 0.54 8.62 0.43 2.88e-16 Coronary artery disease; CRC cis rs4700695 0.920 rs251303 chr5:65248753 A/C cg21114390 chr5:65439923 SFRS12 0.57 6.88 0.35 3.05e-11 Facial morphology (factor 19); CRC cis rs10256972 0.568 rs1133043 chr7:1133305 C/G cg23978390 chr7:1156363 C7orf50 0.58 8.14 0.41 8.41e-15 Longevity;Endometriosis; CRC cis rs7811142 0.830 rs41280971 chr7:99954457 G/T cg00814883 chr7:100076585 TSC22D4 -0.7 -8.77 -0.44 9.58e-17 Platelet count; CRC trans rs2727020 0.521 rs7101761 chr11:49598178 G/A cg03929089 chr4:120376271 NA -0.75 -9.93 -0.48 1.64e-20 Coronary artery disease; CRC cis rs11971779 1.000 rs11971779 chr7:139040258 A/G cg07862535 chr7:139043722 LUC7L2 -0.89 -10.65 -0.51 6.17e-23 Diisocyanate-induced asthma; CRC trans rs5756813 0.754 rs8137848 chr22:38185994 T/G cg19894588 chr14:64061835 NA -0.57 -7.87 -0.4 5.07e-14 Optic cup area;Vertical cup-disc ratio; CRC cis rs6951245 1.000 rs79765398 chr7:1073764 A/G cg07217954 chr7:1067459 C7orf50 0.55 5.66 0.3 3.36e-8 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs832540 0.618 rs2548663 chr5:56172778 G/A cg20203395 chr5:56204925 C5orf35 -0.45 -6.01 -0.31 4.91e-9 Coronary artery disease; CRC cis rs59104589 0.583 rs12624195 chr2:242254734 G/C cg19488206 chr2:242435732 STK25 0.45 6.25 0.33 1.28e-9 Fibrinogen levels; CRC cis rs7618501 0.633 rs7628058 chr3:50039474 C/T cg05623727 chr3:50126028 RBM5 0.46 7.76 0.39 1.1e-13 Intelligence (multi-trait analysis); CRC trans rs7819412 1.000 rs7819412 chr8:11045161 A/G cg06636001 chr8:8085503 FLJ10661 0.59 9.17 0.45 5.34e-18 Triglycerides; CRC cis rs514406 0.679 rs61768344 chr1:53229274 G/A cg25767906 chr1:53392781 SCP2 0.52 8.13 0.41 8.82e-15 Monocyte count; CRC cis rs4481887 0.732 rs6703399 chr1:248416343 T/C cg13385794 chr1:248469461 NA 0.35 6.06 0.32 3.81e-9 Common traits (Other); CRC cis rs1552244 1.000 rs113771705 chr3:10075983 T/C cg18598329 chr3:10140678 FANCD2;C3orf24 -0.89 -11.87 -0.55 2.69e-27 Alzheimer's disease; CRC cis rs412000 0.554 rs2680700 chr17:56440542 G/T cg12560992 chr17:57184187 TRIM37 0.46 6.51 0.34 2.87e-10 Primary tooth development (time to first tooth eruption); CRC cis rs1215050 0.740 rs804051 chr4:98935935 A/T cg05340658 chr4:99064831 C4orf37 -0.47 -7.15 -0.37 5.68e-12 Waist-to-hip ratio adjusted for body mass index; CRC cis rs4253772 0.513 rs12171124 chr22:46710693 A/C cg09491104 chr22:46646882 C22orf40 -0.43 -5.85 -0.31 1.2e-8 LDL cholesterol;Cholesterol, total; CRC cis rs6684514 0.922 rs12128785 chr1:156269389 A/G cg16558208 chr1:156270281 VHLL 0.56 8.73 0.43 1.29e-16 Mean corpuscular hemoglobin concentration;Glycated hemoglobin levels; CRC cis rs9354352 0.967 rs9354351 chr6:66696271 G/A cg07460842 chr6:66804631 NA 0.62 9.07 0.45 1.07e-17 Initial pursuit acceleration in psychotic disorders; CRC cis rs11148252 0.740 rs3803264 chr13:52971893 A/G cg12458913 chr13:53173898 NA -0.48 -7.07 -0.36 9.36e-12 Lewy body disease; CRC cis rs172166 0.694 rs2791332 chr6:28108788 C/T cg20615401 chr6:28092323 ZSCAN16 0.46 6.08 0.32 3.28e-9 Cardiac Troponin-T levels; CRC cis rs9925964 0.804 rs4889606 chr16:31011183 C/T cg03418659 chr16:31128414 MYST1 -0.43 -6.41 -0.33 4.97e-10 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs9300255 0.602 rs1616131 chr12:123619838 G/A cg00376283 chr12:123451042 ABCB9 0.6 8.15 0.41 7.58e-15 Neutrophil percentage of white cells; CRC cis rs2976388 0.578 rs13263987 chr8:143827387 A/C cg24046110 chr8:143859143 LYNX1 -0.43 -6.61 -0.34 1.56e-10 Urinary tract infection frequency; CRC cis rs13108904 0.846 rs3775100 chr4:1225106 T/C cg00684032 chr4:1343700 KIAA1530 0.39 5.93 0.31 7.87e-9 Obesity-related traits; CRC cis rs4757319 0.515 rs4312044 chr11:15341931 G/A cg03245590 chr11:15329459 NA 0.52 8.94 0.44 2.92e-17 Breast cancer; CRC cis rs9818758 0.607 rs34784192 chr3:49274823 G/T cg00383909 chr3:49044727 WDR6 1.16 11.72 0.54 9.45e-27 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; CRC cis rs59104589 0.959 rs60624480 chr2:242297118 G/A cg10021735 chr2:242295487 FARP2 0.42 5.96 0.31 6.57e-9 Fibrinogen levels; CRC cis rs13191362 1.000 rs67046187 chr6:163068532 C/A cg14584255 chr6:163149320 PACRG;PARK2 0.44 6.36 0.33 6.71e-10 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs6717918 0.651 rs2633264 chr2:233124685 C/T ch.2.233013039R chr2:233304795 NA -0.48 -5.86 -0.31 1.15e-8 Height; CRC cis rs4727027 0.704 rs2888600 chr7:148908562 C/T cg23583168 chr7:148888333 NA -0.92 -17.32 -0.69 3.2e-48 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC cis rs6088580 0.634 rs4911153 chr20:32961547 C/T cg08999081 chr20:33150536 PIGU -0.64 -11.8 -0.55 4.81e-27 Glomerular filtration rate (creatinine); CRC cis rs73206853 0.764 rs55929416 chr12:110622543 C/T cg12870014 chr12:110450643 ANKRD13A 0.82 10.61 0.5 8.15e-23 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC cis rs2153535 0.580 rs6597330 chr6:8492076 T/C cg07606381 chr6:8435919 SLC35B3 0.67 10.78 0.51 2.07e-23 Motion sickness; CRC cis rs6460942 1.000 rs2053381 chr7:12400710 C/A cg06484146 chr7:12443880 VWDE -0.76 -7.53 -0.38 4.86e-13 Coronary artery disease; CRC cis rs514406 0.644 rs4926928 chr1:53210163 G/T cg08859206 chr1:53392774 SCP2 -0.42 -6.43 -0.33 4.36e-10 Monocyte count; CRC cis rs12476592 0.602 rs262478 chr2:63872386 T/C cg10828910 chr2:63850056 LOC388955 0.48 5.83 0.31 1.36e-8 Childhood ear infection; CRC cis rs12618769 0.597 rs72821956 chr2:99159966 G/T cg18455616 chr2:99124870 INPP4A 0.35 5.85 0.31 1.16e-8 Bipolar disorder; CRC cis rs6496667 0.779 rs8039288 chr15:91000445 A/T cg04176472 chr15:90893244 GABARAPL3 0.57 8.16 0.41 7.07e-15 Rheumatoid arthritis; CRC trans rs1455244 0.700 rs7229302 chr18:11508904 G/T cg21023284 chr11:6624872 ILK;RRP8 0.39 6.05 0.32 3.89e-9 Schizophrenia; CRC trans rs61931739 0.534 rs11053047 chr12:34161084 C/T cg26384229 chr12:38710491 ALG10B 0.57 7.21 0.37 3.77e-12 Morning vs. evening chronotype; CRC cis rs2404602 0.591 rs11635162 chr15:76951105 C/T cg23625390 chr15:77176239 SCAPER -0.77 -10.17 -0.49 2.71e-21 Blood metabolite levels; CRC cis rs1552244 0.935 rs35515831 chr3:10071362 G/A cg08888203 chr3:10149979 C3orf24 0.69 9.65 0.47 1.46e-19 Alzheimer's disease; CRC cis rs2857891 0.817 rs2638102 chr11:6968610 T/C cg04053776 chr11:6947353 ZNF215 0.41 5.93 0.31 7.5e-9 Response to cytadine analogues (cytosine arabinoside); CRC cis rs9303280 0.776 rs9891174 chr17:38031802 T/A cg11212589 chr17:38028394 ZPBP2 0.43 7.96 0.4 2.89e-14 Self-reported allergy; CRC cis rs6502050 0.835 rs7221451 chr17:80089785 A/G cg02741985 chr17:80059408 CCDC57 0.43 6.99 0.36 1.5e-11 Life satisfaction; CRC cis rs727505 1.000 rs727505 chr7:124462081 C/T cg23710748 chr7:124431027 NA -0.8 -14.58 -0.63 1.66e-37 Lewy body disease; CRC cis rs561341 1.000 rs72823787 chr17:30283809 A/T cg00745463 chr17:30367425 LRRC37B -0.89 -9.78 -0.47 5.21e-20 Hip circumference adjusted for BMI; CRC cis rs422249 0.512 rs174576 chr11:61603510 C/A cg00603274 chr11:61596626 FADS2 -0.39 -5.75 -0.3 2.07e-8 Trans fatty acid levels; CRC cis rs28386778 0.863 rs3760254 chr17:61851751 T/G cg06601766 chr17:61851465 DDX42;CCDC47 0.43 5.92 0.31 7.91e-9 Prudent dietary pattern; CRC cis rs427941 0.550 rs201514 chr7:101768910 T/C cg06246474 chr7:101738831 CUX1 0.37 5.66 0.3 3.27e-8 Plasma omega-3 polyunsaturated fatty acid level (eicosapentaenoic acid); CRC cis rs72772090 0.539 rs11747179 chr5:96112969 C/T cg17330273 chr5:96107758 CAST;ERAP1 -0.66 -6.16 -0.32 2.13e-9 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg16988976 chr2:99953032 EIF5B;TXNDC9 0.49 6.79 0.35 5.25e-11 Response to antipsychotic treatment; CRC trans rs2403907 0.758 rs2823133 chr21:16568941 A/C cg00407105 chr4:90231041 NA -0.4 -6.11 -0.32 2.8e-9 Breast cancer; CRC cis rs6121246 0.697 rs7269866 chr20:30232504 G/A cg13852791 chr20:30311386 BCL2L1 0.61 9.27 0.46 2.48e-18 Mean corpuscular hemoglobin; CRC cis rs9303401 0.659 rs714959 chr17:56628601 A/G cg10487724 chr17:56770010 TEX14;RAD51C 0.76 9.45 0.46 6.4e-19 Cognitive test performance; CRC cis rs478304 0.593 rs4645927 chr11:65482827 C/T cg27068330 chr11:65405492 SIPA1 -0.71 -10.57 -0.5 1.12e-22 Acne (severe); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg26241694 chr19:12512136 ZNF799 0.43 6.1 0.32 2.95e-9 Response to antipsychotic treatment; CRC cis rs9400271 0.632 rs9400262 chr6:109591433 T/C cg01475377 chr6:109611718 NA -0.35 -6.07 -0.32 3.56e-9 Sum neutrophil eosinophil counts;Sum basophil neutrophil counts;White blood cell count;Neutrophil count;Myeloid white cell count;Granulocyte count; CRC cis rs2288073 0.965 rs6545338 chr2:24422156 C/T cg06627628 chr2:24431161 ITSN2 -0.71 -9.9 -0.48 2.12e-20 Venous thromboembolism (SNP x SNP interaction); CRC cis rs9311474 0.629 rs13081028 chr3:52555316 G/A cg05573699 chr3:52720067 GNL3;PBRM1 -0.42 -6.34 -0.33 7.71e-10 Electroencephalogram traits; CRC cis rs10193935 0.901 rs6544536 chr2:42522042 G/A cg27598129 chr2:42591480 NA -0.52 -6.45 -0.33 4.07e-10 Colonoscopy-negative controls vs population controls; CRC cis rs6964587 0.626 rs2106745 chr7:91506635 C/T cg17063962 chr7:91808500 NA -0.58 -9.23 -0.45 3.41e-18 Breast cancer; CRC cis rs6964587 1.000 rs9785013 chr7:91674302 G/A cg17063962 chr7:91808500 NA 0.82 14.45 0.62 5.33e-37 Breast cancer; CRC cis rs4728302 0.838 rs10264922 chr7:133598975 A/G cg03336402 chr7:133662267 EXOC4 -0.45 -6.5 -0.34 2.97e-10 Intelligence;Intelligence (multi-trait analysis); CRC cis rs397969 0.646 rs1638526 chr17:19848450 T/C cg04132472 chr17:19861366 AKAP10 0.39 5.62 0.3 3.98e-8 Platelet count; CRC cis rs9733 0.621 rs12746899 chr1:150579678 A/T cg18016565 chr1:150552671 MCL1 -0.47 -6.98 -0.36 1.62e-11 Tonsillectomy; CRC cis rs11098499 0.691 rs12502524 chr4:120271414 G/A cg24375607 chr4:120327624 NA 0.45 7.28 0.37 2.53e-12 Corneal astigmatism; CRC cis rs7119 0.717 rs12915548 chr15:77818042 A/G cg10437265 chr15:77819839 NA 0.69 12.74 0.57 1.76e-30 Type 2 diabetes; CRC cis rs6499255 0.951 rs1437136 chr16:69672675 G/C cg15192750 chr16:69999425 NA 0.61 8.06 0.41 1.42e-14 IgE levels; CRC cis rs798554 0.679 rs7807978 chr7:2814635 C/T cg04166393 chr7:2884313 GNA12 0.4 6.1 0.32 3.04e-9 Height; CRC cis rs8060686 0.641 rs76053508 chr16:68243054 A/T cg08314208 chr16:67682810 RLTPR -0.6 -6.42 -0.33 4.82e-10 HDL cholesterol;Metabolic syndrome; CRC cis rs694739 0.628 rs508168 chr11:64135435 G/A cg02228329 chr11:64053129 BAD;GPR137 0.5 6.95 0.36 2.01e-11 Alopecia areata;Crohn's disease;Psoriasis vulgaris; CRC cis rs6951245 1.000 rs113066613 chr7:1094128 T/C cg21664854 chr7:1097933 C7orf50;GPR146 0.77 8.73 0.43 1.34e-16 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs2243480 1.000 rs316322 chr7:65611233 G/C cg25985355 chr7:65971099 NA -0.55 -6.22 -0.32 1.49e-9 Diabetic kidney disease; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg09602753 chr10:134574192 INPP5A 0.38 6.16 0.32 2.09e-9 Liver disease severity in Alagille syndrome; CRC cis rs539514 0.627 rs9530463 chr13:76293772 C/T cg04757411 chr13:76259545 LMO7 -0.36 -6.13 -0.32 2.55e-9 Type 1 diabetes; CRC cis rs1577917 1.000 rs10498958 chr6:86649705 C/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A 0.58 7.19 0.37 4.34e-12 Response to antipsychotic treatment; CRC cis rs6121246 0.821 rs3181073 chr20:30307199 A/C cg18721089 chr20:30220636 NA 0.34 6.01 0.31 4.95e-9 Mean corpuscular hemoglobin; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg11496792 chr9:123477254 MEGF9 0.48 6.13 0.32 2.46e-9 Thyroid stimulating hormone; CRC cis rs4423214 0.959 rs11606033 chr11:71154204 A/G cg05163923 chr11:71159392 DHCR7 0.65 9.63 0.47 1.73e-19 Vitamin D levels; CRC trans rs1997103 1.000 rs4590393 chr7:55408990 C/T cg20935933 chr6:143382018 AIG1 0.51 6.65 0.34 1.25e-10 QRS interval (sulfonylurea treatment interaction); CRC cis rs8180040 0.726 rs6774733 chr3:46991241 G/A cg27129171 chr3:47204927 SETD2 0.65 10.31 0.49 8.71e-22 Colorectal cancer; CRC cis rs7811142 1.000 rs2406255 chr7:100053690 T/C cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.59 7.34 0.38 1.66e-12 Platelet count; CRC trans rs7937682 0.924 rs10891283 chr11:111527672 A/G cg18187862 chr3:45730750 SACM1L 0.47 6.82 0.35 4.38e-11 Primary sclerosing cholangitis; CRC cis rs6831352 0.879 rs36034266 chr4:100061388 T/C cg13256891 chr4:100009986 ADH5 -0.65 -8.89 -0.44 4.15e-17 Alcohol dependence; CRC cis rs12477438 0.798 rs6542849 chr2:99578493 G/C cg26064155 chr2:99771622 LIPT1;TSGA10 -0.75 -10.56 -0.5 1.23e-22 Chronic sinus infection; CRC trans rs10242455 0.702 rs115279860 chr7:98994492 C/T cg09045935 chr12:6379348 NA 0.94 6.54 0.34 2.39e-10 Blood metabolite levels; CRC cis rs995000 0.931 rs1168036 chr1:62962734 A/G cg19896129 chr1:63156450 NA -0.45 -6.99 -0.36 1.5e-11 Triglyceride levels; CRC cis rs9903692 0.779 rs6504025 chr17:46166073 G/A cg21215337 chr17:46176117 CBX1 0.42 7.78 0.39 9.74e-14 Pulse pressure; CRC cis rs9467711 0.591 rs13203673 chr6:25979122 T/C cg16898833 chr6:26189333 HIST1H4D 0.79 6.42 0.33 4.65e-10 Autism spectrum disorder or schizophrenia; CRC cis rs2179367 0.887 rs6570965 chr6:149717476 C/A cg11245181 chr6:149772854 ZC3H12D -0.4 -6.29 -0.33 9.9e-10 Dupuytren's disease; CRC cis rs10504229 0.610 rs7011877 chr8:58147181 C/T cg02290350 chr8:58132656 NA -0.53 -7.83 -0.4 6.55e-14 Developmental language disorder (linguistic errors); CRC cis rs6500602 1.000 rs11647946 chr16:4462836 G/A cg08645402 chr16:4508243 NA 0.59 9.81 0.48 4.12e-20 Schizophrenia; CRC cis rs6963495 0.818 rs73190167 chr7:105160418 A/G cg02135003 chr7:105160482 PUS7 -0.9 -12.2 -0.56 1.71e-28 Bipolar disorder (body mass index interaction); CRC cis rs9911578 0.967 rs6416932 chr17:57148991 G/A cg05425664 chr17:57184151 TRIM37 -0.5 -7.98 -0.4 2.38e-14 Intelligence (multi-trait analysis); CRC trans rs7647973 0.593 rs62262730 chr3:49808274 T/G cg21659725 chr3:3221576 CRBN 0.61 6.38 0.33 6.03e-10 Menarche (age at onset); CRC cis rs8062405 0.964 rs9972768 chr16:28861734 A/C cg16576597 chr16:28551801 NUPR1 0.48 6.83 0.35 4.14e-11 Cognitive ability (multi-trait analysis);Cognitive ability; CRC cis rs853679 0.542 rs9393892 chr6:28081394 A/G cg12172441 chr6:28176163 NA 0.61 7.16 0.37 5.36e-12 Depression; CRC cis rs10883723 0.810 rs10883728 chr10:104269301 A/G cg04362960 chr10:104952993 NT5C2 0.44 6.22 0.32 1.5e-9 Allergic disease (asthma, hay fever or eczema); CRC trans rs8002861 0.846 rs12869521 chr13:44478346 A/G cg12856521 chr11:46389249 DGKZ -0.44 -6.98 -0.36 1.61e-11 Leprosy; CRC cis rs34375054 1.000 rs3751178 chr12:125664357 C/T cg02766259 chr12:125626809 AACS 0.33 5.75 0.3 2.08e-8 Post bronchodilator FEV1/FVC ratio; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg02119927 chr10:71078141 HK1 0.44 6.0 0.31 5.15e-9 Anxiety disorder; CRC cis rs912057 0.526 rs737449 chr6:6733729 A/G cg06612196 chr6:6737390 NA -0.64 -10.67 -0.51 5.13e-23 Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction); CRC cis rs2075371 1.000 rs8134 chr7:133974519 A/G cg11752832 chr7:134001865 SLC35B4 0.48 7.44 0.38 8.76e-13 Mean platelet volume; CRC cis rs2839186 0.771 rs13049175 chr21:47641326 G/A cg05896524 chr21:47604654 C21orf56 -0.49 -7.42 -0.38 1.01e-12 Testicular germ cell tumor; CRC cis rs1046896 0.553 rs9893885 chr17:80837107 C/T cg16060761 chr17:80687452 NA -0.45 -5.86 -0.31 1.15e-8 Glycated hemoglobin levels; CRC cis rs6547741 0.717 rs2178197 chr2:27860551 C/T cg27432699 chr2:27873401 GPN1 0.82 16.21 0.67 7.66e-44 Oral cavity cancer; CRC cis rs2019137 0.560 rs10175462 chr2:113988492 G/A cg21550016 chr2:113992930 PAX8;LOC440839;LOC654433 0.64 9.98 0.48 1.14e-20 Lymphocyte counts; CRC cis rs7937682 0.632 rs11214029 chr11:111761230 C/T cg09085632 chr11:111637200 PPP2R1B 0.94 14.63 0.63 1.09e-37 Primary sclerosing cholangitis; CRC cis rs10894147 0.756 rs1016364 chr11:129744872 A/G cg27255275 chr11:129766154 NFRKB 0.39 5.73 0.3 2.23e-8 Obesity-related traits; CRC cis rs2718798 1 rs2718798 chr3:133492088 A/C cg11941060 chr3:133502564 NA -0.37 -5.74 -0.3 2.18e-8 Ankle injury; CRC cis rs9910055 0.530 rs7222349 chr17:42304644 C/T cg13607699 chr17:42295918 UBTF 0.81 13.96 0.61 4.24e-35 Total body bone mineral density; CRC cis rs7772486 0.686 rs9390348 chr6:146044748 C/T cg23711669 chr6:146136114 FBXO30 -0.65 -10.71 -0.51 3.69e-23 Lobe attachment (rater-scored or self-reported); CRC cis rs7274811 0.901 rs1074683 chr20:32304653 C/G cg14921437 chr20:32255988 NECAB3;C20orf134 -0.47 -6.08 -0.32 3.4e-9 Height; CRC trans rs4698169 0.510 rs675984 chr4:17123821 A/G cg20137461 chr3:169782135 GPR160 0.65 6.05 0.32 3.97e-9 Temperament (bipolar disorder); CRC cis rs7216064 1.000 rs4791299 chr17:65930937 A/G cg12091567 chr17:66097778 LOC651250 -0.63 -8.03 -0.4 1.8e-14 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CRC cis rs7223966 1.000 rs9747164 chr17:61864787 T/C cg05941027 chr17:61774174 LIMD2 0.35 5.99 0.31 5.62e-9 Hip circumference adjusted for BMI;Body mass index; CRC trans rs634534 0.591 rs688862 chr11:65733393 A/G cg17712092 chr4:129076599 LARP1B 0.54 8.59 0.43 3.54e-16 Sum eosinophil basophil counts;Eosinophil counts; CRC trans rs7824557 0.583 rs2263512 chr8:11233419 T/G cg06636001 chr8:8085503 FLJ10661 -0.5 -7.44 -0.38 8.67e-13 Retinal vascular caliber; CRC cis rs6867913 1.000 rs12519447 chr5:141457161 G/A cg08523384 chr5:141488047 NDFIP1 0.43 6.31 0.33 8.81e-10 Asthma; CRC cis rs3018066 0.867 rs3109958 chr4:107233188 A/G cg01869342 chr4:106983673 TBCK 0.36 5.61 0.3 4.23e-8 Cancer; CRC cis rs13108904 0.901 rs7673398 chr4:1300077 G/A cg15763984 chr4:1342303 KIAA1530 0.35 6.17 0.32 2.06e-9 Obesity-related traits; CRC cis rs9649213 0.593 rs6465664 chr7:97921834 A/G cg00277769 chr7:97922759 BAIAP2L1 -0.61 -10.79 -0.51 1.87e-23 Prostate cancer (SNP x SNP interaction); CRC cis rs7917772 0.503 rs11191330 chr10:104306160 G/T cg22532475 chr10:104410764 TRIM8 -0.36 -6.78 -0.35 5.48e-11 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC cis rs4713118 0.662 rs149900 chr6:28014597 C/T cg06470822 chr6:28175283 NA 0.9 12.72 0.57 2.11e-30 Parkinson's disease; CRC cis rs6460942 1.000 rs77010200 chr7:12290724 G/A cg06484146 chr7:12443880 VWDE -0.72 -7.19 -0.37 4.3e-12 Coronary artery disease; CRC cis rs10504229 1.000 rs56168206 chr8:58184485 G/A cg22535103 chr8:58192502 C8orf71 -0.82 -12.27 -0.56 9.63e-29 Developmental language disorder (linguistic errors); CRC trans rs12432203 1.000 rs72622434 chr14:51734570 C/T cg14592830 chr9:122318704 NA 0.56 5.99 0.31 5.46e-9 Cancer; CRC trans rs2243480 1.000 rs316318 chr7:65612904 A/G cg10756647 chr7:56101905 PSPH 0.77 7.85 0.4 5.94e-14 Diabetic kidney disease; CRC cis rs853679 0.882 rs9393908 chr6:28190830 T/A cg15786705 chr6:28176104 NA 0.73 6.04 0.32 4.18e-9 Depression; CRC cis rs10504229 1.000 rs9650139 chr8:58190508 G/T cg05313129 chr8:58192883 C8orf71 -0.47 -6.96 -0.36 1.82e-11 Developmental language disorder (linguistic errors); CRC cis rs7296418 0.961 rs7957096 chr12:123544878 A/G cg00376283 chr12:123451042 ABCB9 0.72 11.36 0.53 1.95e-25 Platelet count; CRC cis rs12594515 0.967 rs11857628 chr15:45998206 C/T cg01629716 chr15:45996671 NA 0.38 7.63 0.39 2.55e-13 Waist circumference;Weight; CRC cis rs4711350 1.000 rs10947436 chr6:33739960 A/G cg07979401 chr6:33739406 LEMD2 -0.48 -5.92 -0.31 7.98e-9 Schizophrenia; CRC cis rs9926296 0.605 rs1800287 chr16:89858525 C/G cg27121462 chr16:89883253 FANCA 0.6 9.56 0.47 2.91e-19 Vitiligo; CRC trans rs2303319 0.504 rs56965753 chr2:162597251 A/G cg03774468 chr3:140950104 ACPL2 -0.65 -6.07 -0.32 3.61e-9 Cognitive function; CRC cis rs12760731 0.720 rs2862379 chr1:178442906 T/A cg00404053 chr1:178313656 RASAL2 0.96 9.99 0.48 1.1e-20 Obesity-related traits; CRC cis rs1223397 0.938 rs9395602 chr6:13278753 C/T cg06879394 chr6:13274151 PHACTR1 0.51 6.07 0.32 3.47e-9 Blood pressure; CRC cis rs3806843 0.735 rs778597 chr5:140040665 A/G cg19875535 chr5:140030758 IK 0.64 10.37 0.5 5.35e-22 Depressive symptoms (multi-trait analysis); CRC cis rs60843830 1.000 rs17713396 chr2:227201 C/T cg25945732 chr2:264204 ACP1;SH3YL1 0.72 11.72 0.54 9.41e-27 Spherical equivalent (joint analysis main effects and education interaction); CRC cis rs6810498 0.735 rs16878007 chr4:26051504 A/G cg12925881 chr4:26050407 NA 0.41 7.93 0.4 3.45e-14 Alcohol dependence; CRC cis rs753778 0.667 rs10092439 chr8:142210881 C/T cg23750338 chr8:142222470 SLC45A4 0.45 7.65 0.39 2.23e-13 Reticulocyte fraction of red cells;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; CRC cis rs798554 1.000 rs798554 chr7:2759795 C/T cg19346786 chr7:2764209 NA -0.42 -7.59 -0.39 3.43e-13 Height; CRC cis rs1707322 0.963 rs4630155 chr1:46257110 G/C cg06784218 chr1:46089804 CCDC17 0.59 10.38 0.5 4.93e-22 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs4481887 0.927 rs6587445 chr1:248440915 A/G cg13385794 chr1:248469461 NA 0.4 7.23 0.37 3.39e-12 Common traits (Other); CRC trans rs2189609 0.521 rs2526066 chr16:74037837 A/C cg00697916 chr3:65342644 MAGI1 -0.27 -6.12 -0.32 2.72e-9 Energy expenditure (24h); CRC cis rs7044106 0.791 rs2416798 chr9:123480603 C/T cg09419670 chr9:123605666 PSMD5;LOC253039 0.69 10.68 0.51 4.61e-23 Hip circumference adjusted for BMI; CRC cis rs34172651 0.502 rs12930727 chr16:24838497 G/T cg06505273 chr16:24850292 NA -0.41 -6.15 -0.32 2.27e-9 Intelligence (multi-trait analysis); CRC cis rs262150 0.644 rs2730228 chr7:158789361 T/C cg04239562 chr7:158767014 NA 0.36 5.65 0.3 3.42e-8 Facial morphology (factor 20); CRC cis rs7680126 0.633 rs55766779 chr4:10287039 C/T cg00071950 chr4:10020882 SLC2A9 -0.48 -6.27 -0.33 1.14e-9 Urate levels in lean individuals;Urate levels in overweight individuals;Urate levels in obese individuals; CRC cis rs916888 0.821 rs415430 chr17:44859144 C/T cg01570182 chr17:44337453 NA -1.07 -12.8 -0.58 9.93e-31 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs4731207 0.672 rs7792883 chr7:124448021 A/G cg23710748 chr7:124431027 NA 0.37 5.96 0.31 6.53e-9 Cutaneous malignant melanoma; CRC cis rs3096299 0.967 rs2965827 chr16:89457350 A/C cg01788221 chr16:89496183 ANKRD11 0.45 7.02 0.36 1.3e-11 Multiple myeloma (IgH translocation); CRC cis rs9549328 0.800 rs1317507 chr13:113631780 G/T cg17524180 chr13:113633600 MCF2L -0.65 -12.11 -0.56 3.5e-28 Systolic blood pressure; CRC cis rs7914558 0.966 rs12766205 chr10:104893568 A/G cg04362960 chr10:104952993 NT5C2 0.59 8.75 0.43 1.14e-16 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs1799949 0.683 rs55737636 chr17:41264739 C/T cg07153921 chr17:41440717 NA -0.39 -5.85 -0.31 1.19e-8 Menopause (age at onset); CRC cis rs7626444 0.625 rs1486358 chr3:196485590 T/C cg12930392 chr3:196481615 PAK2 0.39 7.11 0.36 7.25e-12 Monocyte count; CRC cis rs524281 0.861 rs11227410 chr11:65873396 G/C cg14036092 chr11:66035641 RAB1B -0.47 -5.73 -0.3 2.29e-8 Electroencephalogram traits; CRC cis rs1448094 0.512 rs12309296 chr12:86241566 T/C cg19622623 chr12:86230825 RASSF9 -0.41 -6.7 -0.35 9.04e-11 Major depressive disorder; CRC cis rs2692947 0.759 rs11687113 chr2:96658588 A/G cg23100626 chr2:96804247 ASTL 0.27 7.58 0.39 3.53e-13 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; CRC cis rs7904368 0.707 rs12253979 chr10:16853415 T/C cg23933602 chr10:16859644 RSU1 0.57 6.39 0.33 5.7e-10 Ratio of the peak velocity of the mitral E-Wave divided by the peak velocity of the mitral A-wave.; CRC cis rs1559088 0.948 rs3760893 chr19:33597930 C/A cg27124370 chr19:33622961 WDR88 0.45 6.34 0.33 7.42e-10 Bone ultrasound measurement (broadband ultrasound attenuation); CRC cis rs4780355 0.918 rs1646019 chr16:11359680 C/T cg00044050 chr16:11439710 C16orf75 0.42 5.83 0.31 1.31e-8 Crohn's disease and psoriasis; CRC cis rs9322193 0.923 rs11155671 chr6:149972132 G/A cg07701084 chr6:150067640 NUP43 0.55 8.09 0.41 1.13e-14 Lung cancer; CRC trans rs9858542 0.953 rs7648841 chr3:49416825 G/A cg21582582 chr3:182698605 DCUN1D1 -0.52 -6.66 -0.34 1.12e-10 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs6502050 0.835 rs35192339 chr17:80119106 G/A cg25804541 chr17:80189381 SLC16A3 -0.31 -5.95 -0.31 6.84e-9 Life satisfaction; CRC cis rs2549003 1.000 rs2548999 chr5:131831058 G/T cg00255919 chr5:131827918 IRF1 -0.6 -12.12 -0.56 3.45e-28 Asthma (sex interaction); CRC cis rs4481887 0.962 rs10788768 chr1:248456027 G/A cg13385794 chr1:248469461 NA 0.39 6.97 0.36 1.79e-11 Common traits (Other); CRC cis rs1577917 1.000 rs6454513 chr6:86720049 C/A cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A 0.5 6.74 0.35 7e-11 Response to antipsychotic treatment; CRC cis rs7618501 0.633 rs6771546 chr3:49968572 T/C cg24308560 chr3:49941425 MST1R -0.53 -8.81 -0.44 7.46e-17 Intelligence (multi-trait analysis); CRC trans rs7555668 0.628 rs3128372 chr1:112857586 C/G cg21406518 chr20:62794798 MYT1 -0.4 -6.38 -0.33 5.97e-10 Cognitive performance; CRC cis rs910316 0.967 rs4903285 chr14:75609268 A/T cg03030879 chr14:75389066 RPS6KL1 -0.45 -7.1 -0.36 7.69e-12 Height; CRC cis rs2228479 0.557 rs11648881 chr16:89862434 T/C cg19635926 chr16:89946313 TCF25 0.67 6.28 0.33 1.08e-9 Skin colour saturation; CRC cis rs9399135 0.967 rs6908512 chr6:135367757 A/G cg24558204 chr6:135376177 HBS1L 0.49 7.72 0.39 1.41e-13 Red blood cell count; CRC cis rs17270561 0.609 rs6941933 chr6:25745702 T/C cg16482183 chr6:26056742 HIST1H1C 0.83 10.69 0.51 4.46e-23 Iron status biomarkers; CRC cis rs12893668 0.572 rs34000399 chr14:104101417 T/C cg01849466 chr14:104193079 ZFYVE21 -0.41 -6.1 -0.32 2.99e-9 Reticulocyte count; CRC cis rs17213078 0.505 rs6735859 chr2:106744603 T/C cg15412446 chr2:106886593 NA 0.36 5.79 0.3 1.64e-8 Facial morphology (factor 23); CRC trans rs7726839 0.540 rs3792720 chr5:643028 T/G cg11887960 chr12:57824829 NA 0.6 6.7 0.35 9.16e-11 Obesity-related traits; CRC cis rs8060686 0.920 rs73591968 chr16:67803063 G/A cg04539111 chr16:67997858 SLC12A4 -0.51 -5.91 -0.31 8.72e-9 HDL cholesterol;Metabolic syndrome; CRC cis rs116095464 0.558 rs2162870 chr5:228129 G/A cg22857025 chr5:266934 NA -1.21 -16.45 -0.67 8.87e-45 Breast cancer; CRC cis rs17767392 0.681 rs17767266 chr14:71681331 T/C cg13720639 chr14:72061746 SIPA1L1 -0.59 -7.04 -0.36 1.13e-11 Mitral valve prolapse; CRC cis rs11155671 0.530 rs9371544 chr6:150217360 A/G cg07701084 chr6:150067640 NUP43 0.55 7.99 0.4 2.26e-14 Testicular germ cell tumor; CRC cis rs6938 0.534 rs12913293 chr15:75184458 G/C cg05627522 chr15:75251581 NA 0.38 5.88 0.31 1.02e-8 Breast cancer; CRC cis rs6912958 0.703 rs9359748 chr6:88095500 C/T cg12350822 chr6:88032061 C6orf162;GJB7 0.47 9.28 0.46 2.26e-18 Monocyte percentage of white cells; CRC cis rs1552244 0.938 rs9873794 chr3:10074153 T/G cg13047869 chr3:10149882 C3orf24 0.51 7.2 0.37 4.24e-12 Alzheimer's disease; CRC cis rs873946 0.648 rs12767126 chr10:134556992 C/T cg18305652 chr10:134549665 INPP5A 0.48 6.1 0.32 2.98e-9 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CRC cis rs2549003 1.000 rs2070727 chr5:131820275 C/A cg00255919 chr5:131827918 IRF1 0.59 11.92 0.55 1.77e-27 Asthma (sex interaction); CRC cis rs7715806 0.500 rs34355 chr5:74959970 G/A cg19683494 chr5:74908142 NA -0.58 -6.31 -0.33 9.16e-10 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg12187049 chr5:70882888 MCCC2 0.56 7.56 0.38 4.04e-13 Thyroid stimulating hormone; CRC cis rs2249694 0.520 rs7095379 chr10:135328532 C/T cg20169779 chr10:135381914 SYCE1 -0.55 -7.7 -0.39 1.58e-13 Obesity-related traits; CRC cis rs950169 0.579 rs11633088 chr15:84672181 A/T cg11189052 chr15:85197271 WDR73 -0.55 -7.59 -0.39 3.29e-13 Schizophrenia; CRC trans rs12599106 0.629 rs1391904 chr16:34548934 C/T cg07332563 chr6:291687 DUSP22 -0.48 -6.84 -0.35 3.79e-11 Menopause (age at onset); CRC cis rs17152411 1.000 rs7097282 chr10:126593492 T/C cg07906193 chr10:126599966 NA 0.58 6.52 0.34 2.69e-10 Height; CRC trans rs11654801 0.812 rs16962469 chr17:20858432 A/G cg23759823 chr7:139672531 TBXAS1 -0.42 -6.47 -0.34 3.62e-10 Mosquito bite size; CRC cis rs7666738 0.791 rs11729596 chr4:99045461 A/G cg05340658 chr4:99064831 C4orf37 0.6 9.35 0.46 1.36e-18 Colonoscopy-negative controls vs population controls; CRC trans rs2228479 0.850 rs17227057 chr16:89816333 C/T cg24644049 chr4:85504048 CDS1 0.9 7.46 0.38 7.69e-13 Skin colour saturation; CRC cis rs896854 0.967 rs1320164 chr8:95960767 G/A cg13393036 chr8:95962371 TP53INP1 -0.53 -8.91 -0.44 3.62e-17 Type 2 diabetes; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg06911519 chr2:28615662 FOSL2 0.44 6.08 0.32 3.4e-9 Response to antipsychotic treatment; CRC cis rs9549328 0.731 rs2873371 chr13:113616242 C/T cg25790453 chr13:113633590 MCF2L -0.5 -8.63 -0.43 2.6e-16 Systolic blood pressure; CRC cis rs7833986 0.501 rs2719227 chr8:57043794 A/G cg23139584 chr8:56987506 RPS20;SNORD54 -0.82 -11.17 -0.52 9.26e-25 Height; CRC cis rs679087 1.000 rs302317 chr12:29921443 G/A cg14258853 chr12:29935411 TMTC1 -0.46 -7.84 -0.4 6.24e-14 Schizophrenia; CRC cis rs1728785 1.000 rs1170429 chr16:68604126 A/G cg02972257 chr16:68554789 NA -0.6 -7.52 -0.38 5.1e-13 Ulcerative colitis; CRC cis rs6502050 0.835 rs7209474 chr17:80136418 C/T cg19223190 chr17:80058835 NA 0.4 6.29 0.33 1.04e-9 Life satisfaction; CRC cis rs1044826 0.518 rs295488 chr3:139239323 C/T cg00490450 chr3:139108681 COPB2 0.52 7.5 0.38 5.96e-13 Obesity-related traits; CRC cis rs4076764 0.881 rs10917758 chr1:163430652 G/A cg06092702 chr1:163392909 NA -0.53 -8.28 -0.42 3.11e-15 Motion sickness; CRC cis rs2836974 0.533 rs4817999 chr21:40554355 C/A cg11890956 chr21:40555474 PSMG1 -0.9 -15.66 -0.65 1.1e-41 Cognitive function; CRC cis rs7703744 0.681 rs73239280 chr5:118695579 G/A cg02283238 chr5:118691126 TNFAIP8 0.46 6.34 0.33 7.53e-10 Lobe attachment (rater-scored or self-reported); CRC cis rs7659604 1.000 rs7659604 chr4:122665514 A/G cg20573242 chr4:122745356 CCNA2 -0.4 -6.0 -0.31 5.16e-9 Type 2 diabetes; CRC trans rs11148252 0.774 rs7993748 chr13:52941631 C/T cg18335740 chr13:41363409 SLC25A15 0.55 8.95 0.44 2.72e-17 Lewy body disease; CRC cis rs1215050 0.791 rs783960 chr4:98893437 A/G cg05340658 chr4:99064831 C4orf37 -0.49 -7.45 -0.38 8.46e-13 Waist-to-hip ratio adjusted for body mass index; CRC cis rs9527 0.615 rs10883781 chr10:104581130 A/G cg04362960 chr10:104952993 NT5C2 0.63 7.87 0.4 5.2e-14 Arsenic metabolism; CRC cis rs12477438 0.734 rs4851184 chr2:99666434 T/C cg26064155 chr2:99771622 LIPT1;TSGA10 -0.79 -11.26 -0.53 4.44e-25 Chronic sinus infection; CRC cis rs6815814 0.851 rs4274855 chr4:38777471 C/T cg06935464 chr4:38784597 TLR10 0.58 5.79 0.3 1.66e-8 Breast cancer; CRC trans rs6703335 0.870 rs10803142 chr1:243598234 A/G cg06235973 chr19:14183619 LOC113230 0.39 5.96 0.31 6.47e-9 Schizophrenia;Schizophrenia, schizoaffective disorder or bipolar disorder; CRC cis rs4631830 0.540 rs2843562 chr10:51496796 A/G cg20129853 chr10:51489980 NA 0.48 8.55 0.43 4.74e-16 Prostate-specific antigen levels; CRC cis rs9911578 0.935 rs302873 chr17:56769481 C/G cg12560992 chr17:57184187 TRIM37 0.9 16.01 0.66 4.56e-43 Intelligence (multi-trait analysis); CRC cis rs6831352 0.959 rs4699710 chr4:100051819 C/T cg12011299 chr4:100065546 ADH4 0.53 10.92 0.52 6.76e-24 Alcohol dependence; CRC cis rs34333482 1 rs34333482 chr6:116855952 A/AG cg03003256 chr6:116849557 FAM26D;BET3L 0.45 6.92 0.36 2.44e-11 Pelvic organ prolapse (moderate/severe); CRC cis rs4713118 0.869 rs10214440 chr6:27702440 A/C cg03623178 chr6:28175578 NA 0.68 9.49 0.46 4.72e-19 Parkinson's disease; CRC cis rs57221529 0.766 rs72703064 chr5:587825 T/C cg16447950 chr5:562315 NA -0.81 -10.62 -0.51 7.76e-23 Lung disease severity in cystic fibrosis; CRC cis rs7937682 0.924 rs495460 chr11:111504777 G/A cg19812747 chr11:111475976 SIK2 -0.59 -10.07 -0.49 5.54e-21 Primary sclerosing cholangitis; CRC cis rs447 1.000 rs7785708 chr7:83752668 C/T cg22846510 chr7:83753280 SEMA3A -0.55 -7.06 -0.36 1.01e-11 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs1997103 1.000 rs11238364 chr7:55407632 G/T cg17469321 chr7:55412551 NA 0.72 11.28 0.53 3.48e-25 QRS interval (sulfonylurea treatment interaction); CRC cis rs7647973 0.626 rs11709734 chr3:49745235 G/A cg03060546 chr3:49711283 APEH 0.66 8.29 0.42 3e-15 Menarche (age at onset); CRC cis rs7493 1.000 rs2286232 chr7:95039445 C/T cg04155289 chr7:94953770 PON1 -0.59 -7.53 -0.38 5.06e-13 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs10791323 0.569 rs11533204 chr11:133743644 A/G cg06766960 chr11:133703094 NA -0.35 -6.44 -0.33 4.33e-10 Childhood ear infection; CRC cis rs853679 0.550 rs1233707 chr6:28172953 G/A cg12273811 chr6:28175739 NA 0.77 11.05 0.52 2.42e-24 Depression; CRC cis rs758324 0.947 rs11948962 chr5:131113830 C/T cg06307176 chr5:131281290 NA 0.43 6.38 0.33 6.19e-10 Alzheimer's disease in APOE e4- carriers; CRC cis rs4888262 0.508 rs4888258 chr16:74634198 G/T cg01733217 chr16:74700730 RFWD3 0.79 12.02 0.55 7.77e-28 Testicular germ cell tumor; CRC cis rs77972916 0.536 rs7562101 chr2:43592756 T/C cg06169590 chr2:43455088 ZFP36L2;LOC100129726 -0.46 -5.71 -0.3 2.59e-8 Granulocyte percentage of myeloid white cells; CRC cis rs274567 0.501 rs272856 chr5:131687081 G/C cg18758796 chr5:131593413 PDLIM4 0.4 6.29 0.33 9.83e-10 Blood metabolite levels; CRC cis rs877282 0.898 rs10904547 chr10:766283 C/T cg17470449 chr10:769945 NA 0.63 7.97 0.4 2.58e-14 Uric acid levels; CRC cis rs4653767 1.000 rs708773 chr1:226920730 T/C cg05049329 chr1:226924846 ITPKB 0.41 9.04 0.45 1.36e-17 Parkinson's disease; CRC cis rs250677 0.687 rs40523 chr5:148444186 A/T cg23229984 chr5:148520753 ABLIM3 -0.47 -6.57 -0.34 1.92e-10 Breast cancer; CRC trans rs7726839 0.561 rs72703058 chr5:584519 G/A cg25482853 chr8:67687455 SGK3 1.02 12.31 0.56 6.77e-29 Obesity-related traits; CRC trans rs66887589 0.748 rs28439855 chr4:120262256 G/A cg25214090 chr10:38739885 LOC399744 0.39 6.12 0.32 2.67e-9 Diastolic blood pressure; CRC cis rs910316 0.737 rs28687415 chr14:75495482 T/C cg08847533 chr14:75593920 NEK9 0.84 14.64 0.63 9.67e-38 Height; CRC cis rs9905704 0.846 rs2567894 chr17:56794115 G/A cg12560992 chr17:57184187 TRIM37 0.54 7.93 0.4 3.54e-14 Testicular germ cell tumor; CRC cis rs754466 0.606 rs3740250 chr10:79580101 C/T cg26805224 chr10:79626177 DLG5 -0.49 -7.2 -0.37 4.04e-12 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs7809950 0.954 rs2520243 chr7:107136973 T/C cg23024343 chr7:107201750 COG5 -0.61 -8.68 -0.43 1.9e-16 Coronary artery disease; CRC cis rs916888 0.821 rs415430 chr17:44859144 C/T cg17911788 chr17:44343683 NA 0.56 6.86 0.35 3.4e-11 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs853679 0.550 rs1233707 chr6:28172953 G/A cg06470822 chr6:28175283 NA 1.0 15.13 0.64 1.23e-39 Depression; CRC cis rs4917833 0.738 rs7067713 chr10:100221120 T/C cg19043522 chr10:100227446 HPSE2 0.38 5.81 0.31 1.47e-8 Pediatric bone mineral density (femoral neck); CRC cis rs6570726 0.846 rs372904 chr6:145887425 T/C cg13319975 chr6:146136371 FBXO30 -0.4 -5.92 -0.31 8.19e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs62064224 0.554 rs9901737 chr17:30681354 C/G cg25809561 chr17:30822961 MYO1D 0.5 9.0 0.44 1.9e-17 Schizophrenia; CRC cis rs853679 0.766 rs9368561 chr6:28168343 C/T cg06470822 chr6:28175283 NA 0.85 6.98 0.36 1.63e-11 Depression; CRC cis rs11997175 0.624 rs7464055 chr8:33679382 G/A ch.8.33884649F chr8:33765107 NA 0.44 6.26 0.33 1.23e-9 Body mass index; CRC cis rs3772130 0.962 rs9839617 chr3:121516577 A/G cg20356878 chr3:121714668 ILDR1 0.51 8.09 0.41 1.14e-14 Cognitive performance; CRC cis rs4819052 0.851 rs8130285 chr21:46671701 G/C cg02159808 chr21:46707872 POFUT2;LOC642852 0.49 6.52 0.34 2.71e-10 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs2576037 0.501 rs8089938 chr18:44459497 C/T cg19077165 chr18:44547161 KATNAL2 -0.54 -8.57 -0.43 4.09e-16 Personality dimensions; CRC cis rs7680126 0.632 rs11731464 chr4:10148376 G/A cg00071950 chr4:10020882 SLC2A9 -0.48 -5.86 -0.31 1.12e-8 Urate levels in lean individuals;Urate levels in overweight individuals;Urate levels in obese individuals; CRC cis rs853679 0.517 rs9380050 chr6:28048538 A/G cg03623178 chr6:28175578 NA 0.93 12.26 0.56 9.88e-29 Depression; CRC cis rs763121 0.853 rs5750672 chr22:39104168 C/T cg06022373 chr22:39101656 GTPBP1 -0.79 -12.62 -0.57 4.83e-30 Menopause (age at onset); CRC cis rs4481887 1.000 rs11204636 chr1:248492409 A/C cg13385794 chr1:248469461 NA -0.34 -5.67 -0.3 3.05e-8 Common traits (Other); CRC cis rs561341 0.882 rs111484028 chr17:30287701 G/A cg19193384 chr17:30244184 NA -0.53 -6.66 -0.34 1.15e-10 Hip circumference adjusted for BMI; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg06869415 chr14:35183946 CFL2 0.44 6.1 0.32 3.05e-9 Anxiety disorder; CRC cis rs35264875 0.808 rs921675 chr11:68869034 A/G cg01993067 chr11:68851601 TPCN2 -0.42 -5.75 -0.3 2.03e-8 Blond vs. brown hair color; CRC cis rs73206853 0.640 rs871921 chr12:111115113 G/C cg12870014 chr12:110450643 ANKRD13A 0.82 11.61 0.54 2.33e-26 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC cis rs138857 0.515 rs9616373 chr22:50308597 G/A cg22709217 chr22:50311962 ALG12;CRELD2 -0.95 -10.06 -0.49 6.21e-21 Mean platelet volume; CRC cis rs13118159 0.836 rs2293630 chr4:1342521 G/A cg21620606 chr4:1342894 KIAA1530 0.56 10.21 0.49 1.87e-21 Longevity; CRC cis rs2032447 0.670 rs198845 chr6:26107790 A/C cg12310025 chr6:25882481 NA -0.45 -6.25 -0.33 1.29e-9 Intelligence (multi-trait analysis); CRC cis rs77633900 0.614 rs2439991 chr15:76877227 A/G cg21673338 chr15:77095150 SCAPER -0.72 -7.25 -0.37 3.09e-12 Non-glioblastoma glioma;Glioma; CRC cis rs907683 0.545 rs3755054 chr2:220280974 C/T cg15015639 chr2:220282977 DES 0.41 6.71 0.35 8.56e-11 Resting heart rate; CRC cis rs55823223 0.564 rs936391 chr17:73847799 A/G cg10935138 chr17:73851978 WBP2 -0.53 -6.66 -0.34 1.16e-10 Psoriasis; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg13060520 chr10:35379343 CUL2 0.49 6.98 0.36 1.61e-11 Anxiety disorder; CRC trans rs7618501 0.633 rs9814664 chr3:50078541 C/T cg21665057 chr3:196295764 WDR53;FBXO45 -0.58 -9.28 -0.46 2.31e-18 Intelligence (multi-trait analysis); CRC cis rs4713118 0.662 rs156744 chr6:27967274 G/A cg25164649 chr6:28176230 NA 0.65 9.05 0.45 1.29e-17 Parkinson's disease; CRC trans rs11148252 0.967 rs11618716 chr13:53046836 A/G cg18335740 chr13:41363409 SLC25A15 -0.54 -8.59 -0.43 3.6e-16 Lewy body disease; CRC cis rs4474465 0.679 rs4945288 chr11:78244823 C/A cg27205649 chr11:78285834 NARS2 0.51 6.41 0.33 5.07e-10 Alzheimer's disease (survival time); CRC cis rs12541635 0.677 rs6997487 chr8:106965511 A/C cg10147462 chr8:107024639 NA 0.55 9.3 0.46 2.01e-18 Age of smoking initiation; CRC trans rs8141529 0.507 rs5762936 chr22:29381377 A/G cg09868299 chr11:69259957 NA -0.43 -6.19 -0.32 1.82e-9 Lymphocyte counts; CRC cis rs9649213 0.614 rs1006169 chr7:97938443 A/G cg09267113 chr7:98030324 BAIAP2L1 0.93 12.07 0.55 5.08e-28 Prostate cancer (SNP x SNP interaction); CRC cis rs2281845 0.826 rs4915214 chr1:201076290 T/A cg01987224 chr1:201084466 NA 0.54 10.01 0.48 9.4e-21 Permanent tooth development; CRC cis rs71327718 1 rs71327718 chr3:125592857 C/G cg05084668 chr3:125655381 ALG1L -0.79 -9.61 -0.47 1.95e-19 Metabolite levels (HVA/5-HIAA ratio); CRC cis rs8005677 1.000 rs2295685 chr14:23398153 A/G cg01529538 chr14:23388837 RBM23 0.39 6.13 0.32 2.52e-9 Cognitive ability (multi-trait analysis); CRC cis rs514406 0.929 rs11206035 chr1:53323571 T/C cg27535305 chr1:53392650 SCP2 -0.37 -6.77 -0.35 5.97e-11 Monocyte count; CRC trans rs916888 0.773 rs9896243 chr17:44826056 C/G cg23590916 chr17:43697445 MGC57346 0.61 6.14 0.32 2.35e-9 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs9287719 0.753 rs1990613 chr2:10781975 C/T cg00105475 chr2:10696890 NA -0.45 -7.42 -0.38 1e-12 Prostate cancer; CRC trans rs2303319 0.504 rs60824222 chr2:162368719 A/C cg27113153 chr11:123612418 ZNF202 -0.72 -6.17 -0.32 1.96e-9 Cognitive function; CRC cis rs41005 1.000 rs193932 chr2:8107383 C/T cg03155496 chr2:8117019 LOC339788 -0.39 -6.92 -0.36 2.43e-11 Response to anti-TNF therapy in rheumatoid arthritis; CRC trans rs2898857 0.524 rs2072153 chr17:47390014 C/G cg11430096 chr6:110968061 CDK19 -0.51 -7.63 -0.39 2.64e-13 Cancer; CRC cis rs7613875 0.600 rs1061474 chr3:50144951 T/C cg24110177 chr3:50126178 RBM5 0.55 8.32 0.42 2.45e-15 Body mass index; CRC cis rs10504229 0.728 rs17215621 chr8:58152706 C/A cg05313129 chr8:58192883 C8orf71 -0.47 -6.18 -0.32 1.94e-9 Developmental language disorder (linguistic errors); CRC cis rs2228479 1.000 rs2228479 chr16:89985940 G/A cg06558623 chr16:89946397 TCF25 1.05 10.48 0.5 2.35e-22 Skin colour saturation; CRC cis rs1046896 1.000 rs9909940 chr17:80689036 C/T cg02711726 chr17:80685570 FN3KRP -0.59 -9.42 -0.46 8.25e-19 Glycated hemoglobin levels; CRC cis rs1218582 0.741 rs11264281 chr1:154867221 A/G cg16680214 chr1:154839983 KCNN3 -0.52 -9.92 -0.48 1.8899999999999998e-20 Prostate cancer; CRC cis rs4242434 0.927 rs34027561 chr8:22465385 T/C cg03733263 chr8:22462867 KIAA1967 1.04 19.57 0.73 4.28e-57 Exploratory eye movement dysfunction in schizophrenia (cognitive search score); CRC cis rs1008375 0.900 rs6851783 chr4:17578469 A/G cg16339924 chr4:17578868 LAP3 0.67 8.37 0.42 1.62e-15 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs8044868 0.586 rs8182213 chr16:72080005 C/T cg06172871 chr16:72088244 HP 0.44 6.45 0.33 4.08e-10 Body mass index (change over time) in cancer or chronic obstructive pulmonary disease;Body mass index (change over time) in cancer; CRC cis rs7618915 0.547 rs62253700 chr3:52625019 T/A cg15147215 chr3:52552868 STAB1 -0.61 -10.13 -0.49 3.53e-21 Bipolar disorder; CRC cis rs225245 0.817 rs12150359 chr17:34024584 C/T cg05299278 chr17:33885742 SLFN14 0.51 8.28 0.42 3.19e-15 Reticulocyte count;Reticulocyte fraction of red cells;High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells; CRC cis rs4727027 0.899 rs7791496 chr7:148863674 C/G cg12479418 chr7:148823350 ZNF425;ZNF398 0.42 5.76 0.3 1.91e-8 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC cis rs1707322 0.685 rs56177313 chr1:46225806 A/C cg06784218 chr1:46089804 CCDC17 0.66 12.26 0.56 9.89e-29 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC trans rs10411161 0.752 rs10402107 chr19:52384600 A/G cg22319618 chr22:45562946 NUP50 -0.69 -7.57 -0.39 3.9e-13 Breast cancer; CRC cis rs1552244 0.572 rs6442154 chr3:10168785 A/G cg02579736 chr3:10068473 FANCD2;CIDECP 1.01 11.58 0.54 2.98e-26 Alzheimer's disease; CRC cis rs7918232 0.941 rs7907988 chr10:27444344 T/G cg14442939 chr10:27389572 ANKRD26 0.81 8.93 0.44 2.98e-17 Breast cancer; CRC cis rs6076065 0.723 rs6132607 chr20:23390373 C/G cg11657817 chr20:23433608 CST11 -0.42 -6.29 -0.33 1e-9 Facial morphology (factor 15, philtrum width); CRC cis rs5769765 0.862 rs56377703 chr22:50306940 C/T cg02269571 chr22:50332266 NA -0.61 -8.04 -0.41 1.6e-14 Schizophrenia; CRC trans rs4263408 0.934 rs9683743 chr4:39703194 A/C cg21172814 chr1:180199001 LHX4 -0.4 -6.02 -0.31 4.76e-9 Plasma amyloid beta peptide concentrations (ABx-40); CRC cis rs7122539 0.506 rs11227625 chr11:66684151 T/G cg24851651 chr11:66362959 CCS 0.39 6.61 0.34 1.57e-10 HIV-1 susceptibility; CRC cis rs1448094 0.510 rs11117016 chr12:86141602 T/C cg25456477 chr12:86230367 RASSF9 -0.36 -6.15 -0.32 2.31e-9 Major depressive disorder; CRC cis rs6694672 1.000 rs9427661 chr1:196946546 T/C cg13682187 chr1:196946512 CFHR5 -0.51 -8.08 -0.41 1.21e-14 Asthma; CRC cis rs9837602 1.000 rs9878931 chr3:99712634 G/A cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G 0.48 5.74 0.3 2.13e-8 Breast cancer; CRC cis rs8180040 0.620 rs11715121 chr3:47072621 T/A cg10298567 chr3:47292165 KIF9 0.38 5.93 0.31 7.63e-9 Colorectal cancer; CRC cis rs2108622 0.727 rs12610189 chr19:15978641 T/G cg13772218 chr19:15982569 NA 0.48 6.72 0.35 8.16e-11 Circulating phylloquinone levels;Vitamin E levels;Acenocoumarol maintenance dosage;Response to Vitamin E supplementation;Metabolite levels;Warfarin maintenance dose; CRC trans rs55675132 0.548 rs17274725 chr1:115377469 C/T cg25493687 chr8:27288214 PTK2B 0.49 6.0 0.31 5.23e-9 Schizophrenia; CRC cis rs2836950 0.565 rs2836934 chr21:40564885 A/C cg06238570 chr21:40685208 BRWD1 -0.61 -8.82 -0.44 6.66e-17 Menarche (age at onset); CRC cis rs6952808 1.000 rs6977733 chr7:1886725 A/T cg22963979 chr7:1858916 MAD1L1 0.65 10.04 0.48 7.38e-21 Bipolar disorder and schizophrenia; CRC trans rs2324229 0.797 rs1180237 chr6:83943928 A/C cg11251499 chr4:57774202 REST -0.44 -6.46 -0.34 3.79e-10 Platelet-derived growth factor BB levels; CRC cis rs9916302 0.904 rs6503503 chr17:37514373 G/A cg00129232 chr17:37814104 STARD3 0.54 7.85 0.4 5.97e-14 Glomerular filtration rate (creatinine); CRC cis rs4665809 0.590 rs7606351 chr2:26292545 A/C cg25036284 chr2:26402008 FAM59B -0.47 -5.82 -0.31 1.41e-8 Gut microbiome composition (summer); CRC cis rs9457247 1.000 rs364451 chr6:167384756 G/A cg23791538 chr6:167370224 RNASET2 -0.37 -5.76 -0.3 1.98e-8 Crohn's disease; CRC cis rs6495122 0.501 rs6495144 chr15:75343438 T/C cg18612461 chr15:75251733 NA -0.37 -5.71 -0.3 2.48e-8 Caffeine consumption;Diastolic blood pressure;Coffee consumption; CRC cis rs1322512 0.876 rs1744372 chr6:152944926 C/G cg03415253 chr6:152958462 SYNE1 -0.41 -6.38 -0.33 6.06e-10 Tonometry; CRC cis rs911186 0.782 rs34569203 chr6:27153984 A/C cg12292205 chr6:26970375 C6orf41 -0.79 -8.34 -0.42 1.99e-15 Autism spectrum disorder or schizophrenia; CRC cis rs2204008 0.604 rs2320521 chr12:38253789 A/G cg13010199 chr12:38710504 ALG10B 0.44 5.73 0.3 2.33e-8 Bladder cancer; CRC cis rs16937 0.662 rs10900456 chr1:205145005 C/T cg00857998 chr1:205179979 DSTYK 0.41 5.68 0.3 3.04e-8 Schizophrenia; CRC cis rs6546550 0.901 rs7419837 chr2:70146625 T/C cg02498382 chr2:70120550 SNRNP27 -0.56 -9.52 -0.46 3.78e-19 Prevalent atrial fibrillation; CRC cis rs2019137 0.539 rs4849177 chr2:113982584 T/C cg02675527 chr2:114030824 PAX8;LOC440839 -0.43 -6.44 -0.33 4.28e-10 Lymphocyte counts; CRC cis rs2067615 0.579 rs4964486 chr12:107140790 A/G cg13491945 chr12:107078410 RFX4 0.35 5.95 0.31 7.03e-9 Heart rate; CRC cis rs9388451 0.807 rs1269175 chr6:126040435 A/G cg05901451 chr6:126070800 HEY2 0.56 9.17 0.45 5.44e-18 Brugada syndrome; CRC cis rs4853012 0.838 rs4452177 chr2:74345206 A/G cg19729930 chr2:74357872 NA 0.66 10.33 0.49 7.42e-22 Gestational age at birth (maternal effect); CRC cis rs593982 1.000 rs650619 chr11:65506483 G/A cg08755490 chr11:65554678 OVOL1 1.17 17.1 0.69 2.26e-47 Atopic dermatitis; CRC cis rs6964587 1.000 rs1859037 chr7:91568272 A/G cg17063962 chr7:91808500 NA -0.77 -13.13 -0.59 5.96e-32 Breast cancer; CRC cis rs3820928 1.000 rs3820928 chr2:227773466 A/G cg11843606 chr2:227700838 RHBDD1 -0.4 -5.79 -0.3 1.67e-8 Pulmonary function; CRC cis rs1355223 0.583 rs2941041 chr11:34874734 A/C cg11058730 chr11:34937778 PDHX;APIP 0.73 11.94 0.55 1.54e-27 Systemic lupus erythematosus and Systemic sclerosis; CRC cis rs365302 1.000 rs365302 chr6:159646333 C/T cg14500486 chr6:159655392 FNDC1 -0.43 -6.75 -0.35 6.87e-11 Coronary heart disease; CRC cis rs6860806 0.507 rs273901 chr5:131694360 G/T cg09877947 chr5:131593287 PDLIM4 0.43 7.01 0.36 1.33e-11 Breast cancer; CRC cis rs910316 1.000 rs876402 chr14:75601862 C/T cg08847533 chr14:75593920 NEK9 -0.94 -18.41 -0.71 1.63e-52 Height; CRC cis rs6933660 0.745 rs9322320 chr6:151751908 C/G cg10883421 chr6:151773342 RMND1;C6orf211 0.76 13.33 0.59 1.07e-32 Menarche (age at onset); CRC cis rs5769765 0.955 rs9616394 chr22:50314927 G/C cg08270630 chr22:50330655 NA -0.4 -5.75 -0.3 2e-8 Schizophrenia; CRC cis rs801193 0.548 rs2109297 chr7:66122384 G/A cg12463550 chr7:65579703 CRCP -0.46 -6.16 -0.32 2.1e-9 Aortic root size; CRC cis rs951366 0.903 rs708723 chr1:205739266 C/T cg17178900 chr1:205818956 PM20D1 0.43 6.35 0.33 7.09e-10 Menarche (age at onset); CRC trans rs1814175 0.817 rs11040700 chr11:50023832 C/T cg15704280 chr7:45808275 SEPT13 -1.0 -20.62 -0.75 3.22e-61 Height; CRC cis rs7613875 0.600 rs7061 chr3:50114515 C/T cg05623727 chr3:50126028 RBM5 -0.63 -10.96 -0.52 4.86e-24 Body mass index; CRC cis rs4319547 0.695 rs10773167 chr12:122934001 C/T cg05707623 chr12:122985044 ZCCHC8 -0.78 -9.59 -0.47 2.29e-19 Body mass index; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg00063649 chr15:67813698 C15orf61 0.44 5.98 0.31 5.77e-9 Anxiety disorder; CRC cis rs6951245 0.554 rs4724294 chr7:1139695 G/A cg03188948 chr7:1209495 NA 0.5 5.96 0.31 6.54e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs3858526 0.665 rs10839170 chr11:6003512 C/T cg05234568 chr11:5960015 NA -0.44 -5.66 -0.3 3.27e-8 DNA methylation (variation); CRC cis rs11630290 1.000 rs72750981 chr15:63983737 A/T cg12036633 chr15:63758958 NA -0.55 -5.72 -0.3 2.42e-8 Iris characteristics; CRC cis rs2204008 0.776 rs8186824 chr12:38316537 A/C cg13010199 chr12:38710504 ALG10B 0.46 6.33 0.33 8.25e-10 Bladder cancer; CRC cis rs875971 0.830 rs28714531 chr7:65968237 G/A cg18876405 chr7:65276391 NA 0.51 8.19 0.41 5.69e-15 Aortic root size; CRC cis rs4713118 0.696 rs2394002 chr6:27748015 G/A cg26587870 chr6:27730563 NA -0.45 -6.57 -0.34 2.01e-10 Parkinson's disease; CRC cis rs12936587 0.564 rs7208561 chr17:17615528 C/T cg16928487 chr17:17741425 SREBF1 -0.37 -6.21 -0.32 1.56e-9 Hip circumference;Coronary artery disease or large artery stroke;Coronary heart disease;Coronary artery disease; CRC cis rs875971 0.638 rs6460305 chr7:66060408 G/A cg25985355 chr7:65971099 NA 0.32 5.7 0.3 2.62e-8 Aortic root size; CRC cis rs4654899 1.000 rs7554997 chr1:21400139 C/T cg02927042 chr1:21476669 EIF4G3 -0.48 -7.49 -0.38 6.56e-13 Superior frontal gyrus grey matter volume; CRC cis rs7918232 0.941 rs788220 chr10:27447205 T/C cg14240646 chr10:27532245 ACBD5 0.82 9.18 0.45 5.07e-18 Breast cancer; CRC cis rs116095464 0.558 rs10036253 chr5:238519 A/C cg22857025 chr5:266934 NA -1.25 -16.75 -0.68 5.7e-46 Breast cancer; CRC trans rs10504229 1.000 rs67630725 chr8:58185580 G/A cg04077850 chr5:125800366 GRAMD3 0.37 6.27 0.33 1.15e-9 Developmental language disorder (linguistic errors); CRC cis rs11608355 0.846 rs4766598 chr12:109853306 A/G cg19025524 chr12:109796872 NA -0.46 -6.13 -0.32 2.58e-9 Neuroticism; CRC trans rs11252926 0.574 rs10904065 chr10:423226 G/T cg00953403 chr17:74099816 EXOC7 -0.5 -6.79 -0.35 5.34e-11 Psychosis in Alzheimer's disease; CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg02252918 chr12:124458442 ZNF664;CCDC92 -0.6 -7.31 -0.37 2.1e-12 Diisocyanate-induced asthma; CRC trans rs67073037 0.955 rs12620770 chr2:29144892 C/T cg13899017 chr1:159158444 CADM3 -0.36 -6.09 -0.32 3.16e-9 Breast cancer;Breast cancer (estrogen-receptor negative); CRC cis rs2290159 0.800 rs6792773 chr3:12668726 C/T cg23032965 chr3:12705835 RAF1 0.5 6.38 0.33 5.92e-10 Cholesterol, total; CRC cis rs2795502 0.630 rs873300 chr10:43537155 C/T cg08461752 chr10:43522343 NA -0.78 -7.0 -0.36 1.42e-11 Blood protein levels; CRC cis rs11212617 1.000 rs660429 chr11:108181511 A/C cg12106634 chr11:108092400 ATM;NPAT 0.41 6.11 0.32 2.85e-9 Response to metformin in type 2 diabetes (glycemic); CRC cis rs11098499 0.865 rs28753180 chr4:120405367 A/T cg24375607 chr4:120327624 NA 0.49 7.68 0.39 1.78e-13 Corneal astigmatism; CRC cis rs1348850 0.651 rs4893821 chr2:178229352 A/G cg22681709 chr2:178499509 PDE11A 0.34 6.14 0.32 2.43e-9 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs16858210 0.837 rs1879254 chr3:183609471 C/T cg25686905 chr3:183603175 PARL -0.41 -5.74 -0.3 2.18e-8 Menopause (age at onset); CRC trans rs2797160 1.000 rs2211420 chr6:125995549 A/G cg05039488 chr6:79577232 IRAK1BP1 -0.49 -7.42 -0.38 1.03e-12 Endometrial cancer; CRC cis rs597583 0.715 rs4938399 chr11:117398399 C/T cg27161313 chr11:117392002 DSCAML1 -0.46 -5.75 -0.3 1.99e-8 Putamen volume; CRC cis rs7809950 0.906 rs2395907 chr7:107253304 A/G cg23024343 chr7:107201750 COG5 0.63 8.96 0.44 2.48e-17 Coronary artery disease; CRC cis rs7731657 0.537 rs2189504 chr5:130298900 C/A cg08523029 chr5:130500466 HINT1 -0.49 -6.19 -0.32 1.75e-9 Fasting plasma glucose; CRC cis rs6032067 0.929 rs17424868 chr20:43818519 T/G cg10761708 chr20:43804764 PI3 0.5 5.65 0.3 3.49e-8 Blood protein levels; CRC cis rs9322193 0.923 rs2297930 chr6:150039496 T/C cg07701084 chr6:150067640 NUP43 0.56 8.2 0.41 5.45e-15 Lung cancer; CRC cis rs7258465 0.965 rs271628 chr19:18624333 A/G cg10790698 chr19:18539756 SSBP4 -0.45 -8.71 -0.43 1.53e-16 Breast cancer; CRC cis rs6570726 0.791 rs365747 chr6:145866784 C/T cg23711669 chr6:146136114 FBXO30 0.76 13.25 0.59 2.17e-32 Lobe attachment (rater-scored or self-reported); CRC cis rs6754311 0.773 rs309180 chr2:136614255 A/G cg15123519 chr2:136567270 LCT -0.33 -6.57 -0.34 1.93e-10 Mosquito bite size; CRC trans rs951252 0.504 rs11734405 chr4:146081096 C/T cg10387458 chr1:93645817 TMED5;CCDC18 0.46 6.14 0.32 2.43e-9 Hip circumference; CRC cis rs7429990 0.965 rs1013431 chr3:48029118 A/C cg11946769 chr3:48343235 NME6 -0.43 -5.71 -0.3 2.58e-8 Educational attainment (years of education); CRC cis rs17095355 1.000 rs61614979 chr10:111743994 A/G cg00817464 chr10:111662876 XPNPEP1 -0.61 -8.39 -0.42 1.43e-15 Biliary atresia; CRC cis rs17270561 0.636 rs9379779 chr6:25695441 G/T cg17691542 chr6:26056736 HIST1H1C 0.6 7.32 0.37 1.87e-12 Iron status biomarkers; CRC cis rs765787 0.530 rs10467979 chr15:45521270 G/A cg24006582 chr15:45444508 DUOX1 -0.56 -8.43 -0.42 1.07e-15 Uric acid levels; CRC cis rs4700695 0.764 rs251278 chr5:65381826 G/A cg21114390 chr5:65439923 SFRS12 -0.47 -6.11 -0.32 2.83e-9 Facial morphology (factor 19); CRC cis rs2180341 0.680 rs9388554 chr6:127576234 C/G cg24812749 chr6:127587940 RNF146 0.74 10.9 0.51 8.27e-24 Breast cancer; CRC cis rs798554 0.610 rs2248390 chr7:2855594 T/C cg04166393 chr7:2884313 GNA12 0.39 5.96 0.31 6.49e-9 Height; CRC cis rs1129187 0.755 rs3818554 chr6:42934620 C/T cg21280719 chr6:42927975 GNMT -0.46 -10.32 -0.49 8.05e-22 Alzheimer's disease in APOE e4+ carriers; CRC cis rs1538970 0.810 rs12067642 chr1:45927517 G/T cg05343316 chr1:45956843 TESK2 0.74 10.4 0.5 4.32e-22 Platelet count; CRC cis rs13191362 0.935 rs35942036 chr6:163163297 C/T cg14584255 chr6:163149320 PACRG;PARK2 0.4 5.72 0.3 2.35e-8 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs57590327 0.503 rs7618973 chr3:81619588 C/T cg07356753 chr3:81810745 GBE1 0.52 6.94 0.36 2.13e-11 Extraversion; CRC cis rs2404602 0.735 rs437131 chr15:76781051 C/T cg03037974 chr15:76606532 NA 0.55 8.44 0.42 1.03e-15 Blood metabolite levels; CRC cis rs873946 0.564 rs2803992 chr10:134550882 T/C cg26818010 chr10:134567672 INPP5A -0.58 -8.31 -0.42 2.52e-15 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CRC cis rs4819052 0.851 rs2877019 chr21:46658647 G/A cg02159808 chr21:46707872 POFUT2;LOC642852 0.49 6.42 0.33 4.83e-10 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs1552244 1.000 rs17032278 chr3:10077955 A/G cg16606324 chr3:10149918 C3orf24 0.73 9.77 0.47 5.73e-20 Alzheimer's disease; CRC cis rs4481887 1.000 rs11204626 chr1:248458974 T/A cg00666640 chr1:248458726 OR2T12 0.54 9.66 0.47 1.38e-19 Common traits (Other); CRC cis rs1941023 0.584 rs2241920 chr11:60164204 A/G cg08716584 chr11:60157161 MS4A7 0.56 9.66 0.47 1.36e-19 Congenital heart disease (maternal effect); CRC cis rs11098499 0.754 rs4443261 chr4:120249301 T/C cg09307838 chr4:120376055 NA 0.62 9.66 0.47 1.37e-19 Corneal astigmatism; CRC cis rs617791 0.530 rs10896073 chr11:65762814 T/C cg27068330 chr11:65405492 SIPA1 -0.48 -6.58 -0.34 1.86e-10 Breast cancer; CRC cis rs4481887 1.000 rs10888358 chr1:248471467 C/A cg00666640 chr1:248458726 OR2T12 0.54 9.63 0.47 1.74e-19 Common traits (Other); CRC cis rs7208859 0.524 rs73988172 chr17:29086332 A/C cg01831904 chr17:28903510 LRRC37B2 -0.63 -6.62 -0.34 1.47e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs7677751 0.806 rs60806423 chr4:55086816 C/T cg00691999 chr4:55094011 PDGFRA 0.44 6.27 0.33 1.13e-9 Corneal astigmatism; CRC cis rs7586879 0.616 rs12713422 chr2:25134497 A/C cg22495460 chr2:25135724 ADCY3 -0.89 -17.5 -0.69 5.99e-49 Body mass index; CRC cis rs6717918 0.561 rs2633260 chr2:233132810 T/C ch.2.233013039R chr2:233304795 NA 0.54 6.37 0.33 6.28e-10 Height; CRC cis rs9322193 0.924 rs9498382 chr6:149932118 A/G cg07701084 chr6:150067640 NUP43 0.54 7.96 0.4 2.81e-14 Lung cancer; CRC cis rs7542091 0.704 rs9429825 chr1:210052133 C/G cg23283495 chr1:209979779 IRF6 0.35 6.05 0.32 3.88e-9 Monobrow; CRC cis rs3768617 0.565 rs10752898 chr1:183077896 A/G ch.1.3577855R chr1:183094577 LAMC1 0.79 13.78 0.61 1.95e-34 Fuchs's corneal dystrophy; CRC cis rs3845702 1.000 rs3845702 chr2:180848488 A/C cg23417306 chr2:180868811 CWC22 0.42 5.97 0.31 5.99e-9 Schizophrenia; CRC cis rs9928842 0.823 rs6564243 chr16:75296001 A/C cg08657710 chr16:75258780 CTRB1 -0.56 -6.5 -0.34 2.97e-10 Alcoholic chronic pancreatitis; CRC cis rs951366 0.789 rs823152 chr1:205736285 G/A cg07167872 chr1:205819463 PM20D1 0.83 13.11 0.59 7.1e-32 Menarche (age at onset); CRC cis rs910316 1.000 rs4903279 chr14:75546583 C/T cg03030879 chr14:75389066 RPS6KL1 -0.46 -7.27 -0.37 2.64e-12 Height; CRC cis rs559928 0.597 rs2096706 chr11:63924446 T/G cg19465662 chr11:63993652 NUDT22;TRPT1 0.69 6.43 0.33 4.61e-10 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; CRC cis rs35110281 0.667 rs2250773 chr21:45087786 T/C cg01579765 chr21:45077557 HSF2BP -0.35 -6.65 -0.34 1.19e-10 Mean corpuscular volume; CRC cis rs449789 0.857 rs625687 chr6:159703294 G/A cg14500486 chr6:159655392 FNDC1 -0.48 -7.4 -0.38 1.13e-12 Pulse pressure; CRC cis rs7666738 0.830 rs11723283 chr4:99001617 C/T cg05340658 chr4:99064831 C4orf37 0.61 9.54 0.47 3.44e-19 Colonoscopy-negative controls vs population controls; CRC cis rs1003719 0.715 rs8129942 chr21:38552070 A/G cg10648535 chr21:38446584 PIGP;TTC3 -0.51 -7.12 -0.37 6.73e-12 Eye color traits; CRC cis rs8072100 0.967 rs8072644 chr17:45653364 A/T cg08085267 chr17:45401833 C17orf57 0.62 9.93 0.48 1.76e-20 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg08664810 chr1:92949973 GFI1 0.4 6.16 0.32 2.15e-9 Intelligence (multi-trait analysis); CRC trans rs7027930 0.524 rs16921135 chr9:614252 C/T cg27061366 chr19:13044373 FARSA 0.48 6.15 0.32 2.28e-9 Pulmonary function decline; CRC cis rs1124376 0.882 rs7639282 chr3:20133873 G/A cg05072819 chr3:20081367 KAT2B 0.51 6.08 0.32 3.37e-9 Bipolar disorder and schizophrenia; CRC cis rs4713118 0.513 rs183244 chr6:28031838 C/A cg23161317 chr6:28129485 ZNF389 0.45 6.32 0.33 8.37e-10 Parkinson's disease; CRC cis rs11123610 0.520 rs12996655 chr2:3720900 G/A cg25251562 chr2:3704773 ALLC -0.49 -6.16 -0.32 2.09e-9 Response to inhaled corticosteroid treatment in asthma (change in FEV1); CRC cis rs1506636 1.000 rs2429617 chr7:123418027 A/G cg03229431 chr7:123269106 ASB15 0.73 11.68 0.54 1.34e-26 Plateletcrit;Platelet count; CRC cis rs35306767 0.903 rs12763396 chr10:927357 C/A cg20503657 chr10:835505 NA 0.95 11.98 0.55 1.09e-27 Eosinophil percentage of granulocytes; CRC trans rs10435719 0.867 rs62493601 chr8:11788307 C/T cg06636001 chr8:8085503 FLJ10661 0.48 7.16 0.37 5.18e-12 C-reactive protein levels or triglyceride levels (pleiotropy); CRC cis rs4481887 0.927 rs4307598 chr1:248474544 T/C cg00666640 chr1:248458726 OR2T12 0.47 7.97 0.4 2.56e-14 Common traits (Other); CRC cis rs68170813 0.559 rs2249043 chr7:106960515 C/T cg02696742 chr7:106810147 HBP1 -0.59 -6.4 -0.33 5.35e-10 Coronary artery disease; CRC cis rs758324 0.812 rs519240 chr5:131269453 G/A cg25547332 chr5:131281432 NA -0.37 -5.98 -0.31 5.72e-9 Alzheimer's disease in APOE e4- carriers; CRC cis rs13191362 0.507 rs2849540 chr6:163094522 G/A cg21926612 chr6:163149169 PACRG;PARK2 -0.62 -9.37 -0.46 1.2e-18 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs35306767 0.671 rs11253473 chr10:906826 A/G cg26597838 chr10:835615 NA 0.94 11.76 0.54 6.7399999999999993e-27 Eosinophil percentage of granulocytes; CRC cis rs2274273 0.624 rs67386901 chr14:55757364 C/T cg10130446 chr14:55658398 DLGAP5 -0.4 -5.66 -0.3 3.28e-8 Protein biomarker; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg08056012 chr3:130612679 ATP2C1 0.39 6.2 0.32 1.67e-9 Liver disease severity in Alagille syndrome; CRC cis rs672059 1.000 rs638781 chr1:183157358 T/G ch.1.3577855R chr1:183094577 LAMC1 0.49 7.13 0.37 6.54e-12 Hypertriglyceridemia; CRC trans rs7615952 0.512 rs2922175 chr3:125361360 T/C cg02560186 chr11:3602584 NA -0.63 -9.54 -0.47 3.23e-19 Blood pressure (smoking interaction); CRC cis rs6840360 0.806 rs11932383 chr4:152716136 T/C cg09659197 chr4:152720779 NA -0.51 -10.78 -0.51 2.09e-23 Intelligence (multi-trait analysis); CRC trans rs7618501 1.000 rs6785549 chr3:49736565 G/A cg21582582 chr3:182698605 DCUN1D1 -0.56 -8.28 -0.42 3.08e-15 Intelligence (multi-trait analysis); CRC cis rs7666738 0.753 rs11097607 chr4:99011640 C/T cg05340658 chr4:99064831 C4orf37 0.62 9.64 0.47 1.5700000000000001e-19 Colonoscopy-negative controls vs population controls; CRC cis rs2228479 0.541 rs12918575 chr16:89811151 A/G cg06558623 chr16:89946397 TCF25 0.84 8.8 0.44 7.89e-17 Skin colour saturation; CRC cis rs9443645 0.869 rs9443621 chr6:79576499 A/G cg09184832 chr6:79620586 NA -0.51 -9.54 -0.47 3.31e-19 Intelligence (multi-trait analysis); CRC cis rs3823572 0.564 rs2953632 chr7:133644261 T/A cg03336402 chr7:133662267 EXOC4 -0.66 -10.32 -0.49 8.34e-22 Intelligence (multi-trait analysis); CRC cis rs8177253 0.530 rs8177177 chr3:133463195 A/G cg17775713 chr3:133465469 TF 0.36 6.66 0.34 1.12e-10 Iron status biomarkers; CRC cis rs908922 0.676 rs10788842 chr1:152514588 A/T cg09873164 chr1:152488093 CRCT1 0.39 6.58 0.34 1.84e-10 Hair morphology; CRC cis rs2153535 0.580 rs5001130 chr6:8442298 G/A cg07606381 chr6:8435919 SLC35B3 0.67 10.68 0.51 4.61e-23 Motion sickness; CRC cis rs9467711 0.606 rs67234939 chr6:26530419 A/G cg12315302 chr6:26189340 HIST1H4D 0.75 6.28 0.33 1.05e-9 Autism spectrum disorder or schizophrenia; CRC cis rs10751667 0.560 rs10902267 chr11:1007831 T/C cg23136738 chr11:925521 AP2A2 -0.4 -6.1 -0.32 3.01e-9 Alzheimer's disease (late onset); CRC cis rs12983728 0.572 rs59114323 chr19:58649994 C/T cg21294424 chr19:58662284 ZNF329 0.52 6.57 0.34 1.98e-10 Cholesterol, total; CRC cis rs9372498 0.536 rs10484286 chr6:118956447 T/C cg22561889 chr6:118971681 C6orf204 0.48 5.92 0.31 8.26e-9 Diastolic blood pressure; CRC cis rs270601 0.770 rs932019 chr5:131599370 T/C cg04518342 chr5:131593106 PDLIM4 0.53 9.84 0.48 3.31e-20 Acylcarnitine levels; CRC cis rs6804368 0.649 rs9819728 chr3:30761827 T/C cg06106510 chr3:30762233 NA 0.35 6.42 0.33 4.67e-10 Blood metabolite levels; CRC cis rs2243480 0.901 rs313808 chr7:65499873 T/G cg18252515 chr7:66147081 NA -1.11 -12.36 -0.56 4.21e-29 Diabetic kidney disease; CRC cis rs7618915 0.501 rs2079929 chr3:52765646 C/T cg05573699 chr3:52720067 GNL3;PBRM1 -0.47 -6.83 -0.35 3.99e-11 Bipolar disorder; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg08467595 chr3:13009117 IQSEC1 -0.39 -6.02 -0.31 4.73e-9 Myopia (pathological); CRC cis rs6951245 1.000 rs75488469 chr7:1102122 A/G cg21664854 chr7:1097933 C7orf50;GPR146 0.78 8.95 0.44 2.65e-17 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs9399135 0.844 rs13209789 chr6:135367916 A/G cg24558204 chr6:135376177 HBS1L 0.49 7.75 0.39 1.18e-13 Red blood cell count; CRC cis rs6500395 1.000 rs11640463 chr16:48644434 A/T cg04672837 chr16:48644449 N4BP1 0.44 6.4 0.33 5.42e-10 Response to tocilizumab in rheumatoid arthritis; CRC cis rs7589728 1.000 rs6720809 chr2:88528943 T/C cg24977027 chr2:88469347 THNSL2 0.53 6.15 0.32 2.29e-9 Plasma clusterin levels; CRC cis rs6502050 0.799 rs9911129 chr17:80087819 C/T cg22110888 chr17:80059540 CCDC57 0.4 6.34 0.33 7.4e-10 Life satisfaction; CRC cis rs909674 0.541 rs5757655 chr22:39797178 C/G cg24399712 chr22:39784796 NA 0.52 10.97 0.52 4.43e-24 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; CRC trans rs8097070 0.661 rs9966711 chr18:23171413 C/G cg09098825 chr3:47866946 DHX30 0.56 6.05 0.32 3.87e-9 Systemic juvenile idiopathic arthritis; CRC cis rs1008375 0.932 rs9884565 chr4:17655096 A/G cg16339924 chr4:17578868 LAP3 0.52 6.84 0.35 3.76e-11 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs11098499 0.954 rs59394118 chr4:120295551 A/G cg09307838 chr4:120376055 NA 0.71 10.88 0.51 9.53e-24 Corneal astigmatism; CRC cis rs1448094 0.549 rs4919770 chr12:86238050 G/T cg00310523 chr12:86230176 RASSF9 0.34 5.77 0.3 1.86e-8 Major depressive disorder; CRC trans rs4650994 1.000 rs17276527 chr1:178520680 G/A cg05059571 chr16:84539110 KIAA1609 -0.48 -7.3 -0.37 2.2e-12 HDL cholesterol levels;HDL cholesterol; CRC cis rs10242455 0.571 rs11734 chr7:99229768 C/G cg18809830 chr7:99032528 PTCD1 0.84 6.39 0.33 5.65e-10 Blood metabolite levels; CRC trans rs13046373 0.905 rs4816372 chr21:32077414 A/T cg26293423 chr5:71613149 MRPS27 -0.38 -5.97 -0.31 6.06e-9 HDL cholesterol; CRC cis rs3204270 0.714 rs7189 chr17:79668897 C/T cg09655341 chr17:79618100 PDE6G 0.58 6.74 0.35 7.07e-11 Dental caries; CRC cis rs910316 0.935 rs11159119 chr14:75636967 C/T cg11812906 chr14:75593930 NEK9 -0.64 -10.05 -0.48 6.71e-21 Height; CRC cis rs7615952 0.641 rs12487875 chr3:125787224 C/A cg18479299 chr3:125709523 NA -0.55 -6.64 -0.34 1.33e-10 Blood pressure (smoking interaction); CRC cis rs2739330 0.789 rs5760109 chr22:24252938 C/G cg18538332 chr22:24372958 LOC391322 -0.72 -11.37 -0.53 1.71e-25 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs367943 1.000 rs348960 chr5:112820651 C/A cg12552261 chr5:112820674 MCC 0.49 7.63 0.39 2.62e-13 Type 2 diabetes; CRC cis rs2000999 0.524 rs12933482 chr16:72189604 A/G cg04254540 chr16:71951199 KIAA0174 -0.77 -6.38 -0.33 6.11e-10 Total cholesterol levels;Cholesterol, total;Blood protein levels;LDL cholesterol levels;Haptoglobin levels;LDL cholesterol; CRC trans rs9354308 0.933 rs55672811 chr6:66571730 G/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.48 6.12 0.32 2.65e-9 Metabolite levels; CRC cis rs9925964 0.933 rs10871454 chr16:31048079 C/T cg03418659 chr16:31128414 MYST1 0.47 6.79 0.35 5.39e-11 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs9325144 0.560 rs7314632 chr12:38636979 C/T cg26384229 chr12:38710491 ALG10B -0.47 -7.0 -0.36 1.41e-11 Morning vs. evening chronotype; CRC trans rs4263408 0.934 rs9683743 chr4:39703194 A/C cg02835734 chr2:28974942 PPP1CB -0.44 -6.43 -0.33 4.49e-10 Plasma amyloid beta peptide concentrations (ABx-40); CRC cis rs7493 1.000 rs2068604 chr7:95041542 G/T cg21856205 chr7:94953877 PON1 -0.49 -6.32 -0.33 8.6e-10 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs2153535 0.601 rs1855765 chr6:8444325 C/T cg21535247 chr6:8435926 SLC35B3 0.48 7.24 0.37 3.19e-12 Motion sickness; CRC cis rs2731664 0.721 rs2450333 chr5:176899546 G/A cg23176889 chr5:176863531 GRK6 -0.73 -16.0 -0.66 4.99e-43 Intelligence (multi-trait analysis); CRC cis rs533581 0.866 rs561795 chr16:88970818 A/G cg16701003 chr16:89028210 CBFA2T3 0.44 6.88 0.35 2.95e-11 Social autistic-like traits; CRC cis rs2832191 0.679 rs2705659 chr21:30363908 G/C cg08807101 chr21:30365312 RNF160 0.71 11.4 0.53 1.38e-25 Dental caries; CRC trans rs3960554 0.808 rs867973 chr7:75686007 G/A cg19862616 chr7:65841803 NCRNA00174 0.75 8.71 0.43 1.51e-16 Eotaxin levels; CRC cis rs7539542 0.556 rs4950888 chr1:202872625 C/T cg19681188 chr1:202830198 LOC148709 0.46 6.67 0.35 1.09e-10 Mean platelet volume; CRC cis rs1387259 0.839 rs7486941 chr12:48578631 C/G cg24011408 chr12:48396354 COL2A1 -0.39 -5.64 -0.3 3.61e-8 Obstructive sleep apnea trait (apnea hypopnea index); CRC cis rs763121 0.853 rs138705 chr22:39133803 C/T cg06544989 chr22:39130855 UNC84B 0.44 6.53 0.34 2.51e-10 Menopause (age at onset); CRC cis rs76878669 0.561 rs10791876 chr11:66169646 C/T cg18002602 chr11:66138449 SLC29A2 -0.31 -6.62 -0.34 1.46e-10 Educational attainment (years of education); CRC cis rs9291683 0.588 rs4280729 chr4:10013861 C/T cg00071950 chr4:10020882 SLC2A9 0.67 12.89 0.58 4.57e-31 Bone mineral density; CRC cis rs3820068 0.581 rs16849152 chr1:15921774 A/C cg24675056 chr1:15929824 NA 0.48 6.52 0.34 2.66e-10 Systolic blood pressure; CRC cis rs10504229 1.000 rs17216957 chr8:58179893 C/T cg02725872 chr8:58115012 NA -0.38 -6.43 -0.33 4.44e-10 Developmental language disorder (linguistic errors); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg25621393 chr5:149737060 TCOF1 0.4 6.16 0.32 2.13e-9 Intelligence (multi-trait analysis); CRC cis rs6964587 0.610 rs6465338 chr7:91450624 T/C cg17063962 chr7:91808500 NA 0.57 8.83 0.44 6.39e-17 Breast cancer; CRC cis rs72772090 0.539 rs114006288 chr5:96118004 C/T cg17330273 chr5:96107758 CAST;ERAP1 -0.63 -5.77 -0.3 1.79e-8 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs9399135 0.527 rs61738492 chr6:135282771 G/A cg22676075 chr6:135203613 NA 0.6 8.83 0.44 6.58e-17 Red blood cell count; CRC cis rs4662945 0.603 rs13002385 chr2:130276865 T/C cg05903289 chr2:130345205 NA -0.41 -8.12 -0.41 9.69e-15 Response to cytidine analogues (gemcitabine); CRC cis rs10847980 0.590 rs79798267 chr12:123321819 A/T cg25930673 chr12:123319894 HIP1R 0.72 6.09 0.32 3.16e-9 Adiponectin levels; CRC cis rs1862618 0.853 rs2113078 chr5:56087190 C/T cg03609598 chr5:56110824 MAP3K1 -0.82 -9.92 -0.48 1.85e-20 Initial pursuit acceleration; CRC cis rs3796352 1.000 rs35737577 chr3:53002557 G/C cg07884673 chr3:53033167 SFMBT1 0.7 6.24 0.33 1.34e-9 Immune reponse to smallpox (secreted IL-2); CRC cis rs11122272 0.735 rs2749723 chr1:231493302 A/G cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.6 -9.09 -0.45 9.53e-18 Hemoglobin concentration; CRC cis rs9549328 0.731 rs2873371 chr13:113616242 C/T cg20742385 chr13:113633654 MCF2L -0.63 -10.69 -0.51 4.36e-23 Systolic blood pressure; CRC cis rs2404602 0.692 rs58889902 chr15:77173070 A/C cg22467129 chr15:76604101 ETFA -0.38 -6.07 -0.32 3.61e-9 Blood metabolite levels; CRC cis rs35110281 0.755 rs4819270 chr21:45020919 G/A cg04455712 chr21:45112962 RRP1B 0.41 7.92 0.4 3.7e-14 Mean corpuscular volume; CRC trans rs7937682 0.961 rs7119563 chr11:111543916 T/A cg18187862 chr3:45730750 SACM1L -0.51 -7.13 -0.37 6.21e-12 Primary sclerosing cholangitis; CRC cis rs9660180 0.967 rs9660106 chr1:1797947 A/G cg13866156 chr1:1669148 SLC35E2 -0.62 -9.4 -0.46 9.66e-19 Body mass index; CRC cis rs6694672 0.867 rs1764800 chr1:197250615 G/A cg13682187 chr1:196946512 CFHR5 0.5 7.05 0.36 1.05e-11 Asthma; CRC trans rs2243480 1.000 rs13220979 chr7:65363204 G/A cg10756647 chr7:56101905 PSPH 0.73 7.85 0.4 5.73e-14 Diabetic kidney disease; CRC cis rs17270561 0.697 rs9366633 chr6:25838054 A/G cg17691542 chr6:26056736 HIST1H1C 0.66 8.88 0.44 4.52e-17 Iron status biomarkers; CRC cis rs7208859 0.623 rs9899268 chr17:29150255 T/C cg13385521 chr17:29058706 SUZ12P 0.74 8.22 0.41 4.85e-15 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC trans rs35110281 0.591 rs230642 chr21:44915533 A/C cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO -0.46 -7.42 -0.38 9.77e-13 Mean corpuscular volume; CRC cis rs1975974 1.000 rs4889703 chr17:21721663 T/C cg18423549 chr17:21743878 NA -0.64 -8.99 -0.44 1.99e-17 Psoriasis; CRC trans rs941408 1.000 rs1640271 chr19:2799979 C/T cg22153745 chr1:153894579 GATAD2B -0.6 -9.25 -0.45 2.99e-18 Total cholesterol levels; CRC cis rs6662572 0.578 rs6662306 chr1:46287286 G/A cg08644498 chr1:46502608 NA 0.44 6.91 0.36 2.59e-11 Blood protein levels; CRC cis rs11105298 0.891 rs10858865 chr12:89846476 G/A cg00757033 chr12:89920650 WDR51B 0.37 6.19 0.32 1.8e-9 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; CRC cis rs477692 0.648 rs10829599 chr10:131321881 C/T cg05714579 chr10:131428358 MGMT 0.5 6.96 0.36 1.81e-11 Response to temozolomide; CRC cis rs4930561 0.714 rs7122250 chr11:67946472 T/C cg04465784 chr11:67976953 SUV420H1 -0.3 -5.98 -0.31 5.78e-9 Breast cancer in childhood cancer survivors;IgG glycosylation; CRC cis rs9486715 0.964 rs6921480 chr6:97066329 C/G cg18709589 chr6:96969512 KIAA0776 -0.47 -6.63 -0.34 1.35e-10 Headache; CRC cis rs9733 0.596 rs12085275 chr1:150650265 T/C cg15448220 chr1:150897856 SETDB1 0.45 6.43 0.33 4.42e-10 Tonsillectomy; CRC cis rs6952808 0.792 rs2056480 chr7:1954301 A/G cg02951883 chr7:2050386 MAD1L1 0.67 10.68 0.51 4.57e-23 Bipolar disorder and schizophrenia; CRC cis rs8014204 0.901 rs2080087 chr14:75365062 C/T cg03030879 chr14:75389066 RPS6KL1 -0.55 -9.1 -0.45 8.77e-18 Caffeine consumption; CRC cis rs9311474 0.539 rs12489828 chr3:52567014 G/T cg01758942 chr3:52551074 STAB1 0.31 6.24 0.33 1.33e-9 Electroencephalogram traits; CRC cis rs7474896 0.609 rs1830612 chr10:37999883 A/G cg25427524 chr10:38739819 LOC399744 -0.59 -7.48 -0.38 7.02e-13 Obesity (extreme); CRC cis rs6700896 0.931 rs1805096 chr1:66102257 C/T cg04111102 chr1:66153794 NA 0.33 5.77 0.3 1.83e-8 C-reactive protein;Mean corpuscular volume;Mean corpuscular hemoglobin; CRC cis rs2361718 0.603 rs12951255 chr17:78085597 A/G cg12100956 chr17:78086420 GAA -0.38 -6.8 -0.35 4.96e-11 Yeast infection; CRC trans rs33794 0.564 rs6799689 chr3:45226973 C/T cg00688460 chr12:48922396 NA 0.27 6.0 0.31 5.07e-9 Lung function (forced expiratory volume in 1 second); CRC cis rs2050392 0.624 rs303436 chr10:30731893 G/T cg18806716 chr10:30721971 MAP3K8 -0.72 -10.77 -0.51 2.33e-23 Inflammatory bowel disease; CRC cis rs1448094 0.512 rs12297441 chr12:86233980 C/T cg02569458 chr12:86230093 RASSF9 0.42 7.22 0.37 3.62e-12 Major depressive disorder; CRC trans rs6550704 0.687 rs9865314 chr3:22634337 A/G cg22081084 chr1:89990230 LRRC8B -0.39 -6.0 -0.31 5.12e-9 Daytime sleep phenotypes; CRC cis rs2382817 0.580 rs6756265 chr2:219095554 G/A cg04880052 chr2:219191631 PNKD -0.42 -6.64 -0.34 1.3100000000000001e-10 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; CRC cis rs7613875 0.580 rs2624819 chr3:50010571 G/T cg24110177 chr3:50126178 RBM5 -0.59 -9.21 -0.45 4.07e-18 Body mass index; CRC cis rs9487051 0.639 rs2884012 chr6:109598221 C/T cg12927641 chr6:109611667 NA -0.36 -6.44 -0.33 4.15e-10 Reticulocyte fraction of red cells; CRC cis rs12325245 0.536 rs12931124 chr16:58620063 G/A cg02549819 chr16:58548995 SETD6 1.2 7.97 0.4 2.72e-14 Schizophrenia; CRC cis rs10504229 0.569 rs75466737 chr8:58055034 A/G cg24829409 chr8:58192753 C8orf71 -0.68 -8.29 -0.42 2.99e-15 Developmental language disorder (linguistic errors); CRC cis rs10946940 0.632 rs9366698 chr6:27672035 C/G cg06470822 chr6:28175283 NA 0.55 6.83 0.35 4.12e-11 Systemic lupus erythematosus; CRC cis rs477895 0.653 rs11606544 chr11:63896901 C/T cg05016508 chr11:63871570 FLRT1;MACROD1 0.52 6.67 0.34 1.11e-10 Mean platelet volume; CRC cis rs7917772 0.582 rs7075269 chr10:104365724 C/T cg11453585 chr10:104263688 ACTR1A;SUFU 0.81 14.89 0.63 1.07e-38 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC cis rs11212617 0.967 rs7942014 chr11:108326174 G/C cg12106634 chr11:108092400 ATM;NPAT 0.39 5.67 0.3 3.13e-8 Response to metformin in type 2 diabetes (glycemic); CRC cis rs9818758 0.556 rs9880309 chr3:49304329 G/C cg07636037 chr3:49044803 WDR6 -0.72 -6.08 -0.32 3.38e-9 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; CRC cis rs7552404 0.924 rs1694419 chr1:76219801 C/T cg10523679 chr1:76189770 ACADM 0.73 11.21 0.53 6.53e-25 Blood metabolite levels;Acylcarnitine levels; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg23711144 chr16:3108784 MMP25 0.45 6.21 0.32 1.62e-9 Response to antipsychotic treatment; CRC cis rs10791097 0.694 rs2155749 chr11:130751094 G/T cg12179176 chr11:130786555 SNX19 0.75 12.6 0.57 5.52e-30 Autism spectrum disorder or schizophrenia;Schizophrenia; CRC cis rs4713118 0.869 rs6922574 chr6:27693003 A/T cg08798685 chr6:27730294 NA -0.42 -6.09 -0.32 3.08e-9 Parkinson's disease; CRC cis rs13272623 0.502 rs268601 chr8:71518548 C/T cg23757474 chr8:71581111 LACTB2;XKR9 -0.45 -6.55 -0.34 2.28e-10 IgG glycosylation; CRC cis rs2243480 0.901 rs73148097 chr7:65431787 A/C cg18252515 chr7:66147081 NA -1.08 -12.36 -0.56 4.53e-29 Diabetic kidney disease; CRC cis rs1707322 1.000 rs10158032 chr1:46332701 T/C cg06784218 chr1:46089804 CCDC17 0.5 8.77 0.44 9.45e-17 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs10979 0.965 rs9376758 chr6:143886878 G/A cg25407410 chr6:143891975 LOC285740 -0.8 -12.85 -0.58 6.45e-31 Hypospadias; CRC cis rs748404 0.631 rs1133395 chr15:43650384 G/A cg02155558 chr15:43621948 ADAL;LCMT2 0.53 7.76 0.39 1.09e-13 Lung cancer; CRC cis rs1003719 0.680 rs2187577 chr21:38533341 A/G cg10648535 chr21:38446584 PIGP;TTC3 -0.48 -6.71 -0.35 8.71e-11 Eye color traits; CRC cis rs3087591 0.922 rs2905879 chr17:29545431 T/A cg24425628 chr17:29625626 OMG;NF1 0.87 16.72 0.68 7.54e-46 Hip circumference; CRC cis rs2228479 0.850 rs62054601 chr16:89811751 C/G cg19635926 chr16:89946313 TCF25 0.66 5.97 0.31 6.1e-9 Skin colour saturation; CRC cis rs6502050 0.787 rs8080682 chr17:80058901 G/A cg19223190 chr17:80058835 NA -0.5 -7.97 -0.4 2.55e-14 Life satisfaction; CRC cis rs7707921 1.000 rs749402 chr5:81561325 C/T cg17942617 chr5:81327376 ATG10 0.39 5.8 0.3 1.53e-8 Breast cancer; CRC cis rs11585357 0.793 rs112597506 chr1:17628832 A/G cg08277548 chr1:17600880 PADI3 -0.92 -11.65 -0.54 1.75e-26 Hair shape; CRC cis rs7512552 0.839 rs2794684 chr1:150320571 C/T cg15654264 chr1:150340011 RPRD2 0.58 8.1 0.41 1.08e-14 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg04363768 chr8:56793160 LYN 0.44 6.47 0.34 3.46e-10 Response to antipsychotic treatment; CRC cis rs4481887 1.000 rs4554750 chr1:248496530 C/G cg13385794 chr1:248469461 NA 0.39 6.68 0.35 9.97e-11 Common traits (Other); CRC cis rs10791323 0.572 rs10750551 chr11:133737462 G/A cg15485101 chr11:133734466 NA 0.47 8.05 0.41 1.51e-14 Childhood ear infection; CRC trans rs80033912 0.713 rs7629936 chr3:49836707 G/A cg21665057 chr3:196295764 WDR53;FBXO45 0.52 6.63 0.34 1.4e-10 Intelligence (multi-trait analysis); CRC cis rs2857891 0.695 rs2857887 chr11:6984001 A/G cg04053776 chr11:6947353 ZNF215 0.41 6.21 0.32 1.61e-9 Response to cytadine analogues (cytosine arabinoside); CRC trans rs1455244 0.700 rs7229302 chr18:11508904 G/T cg23388714 chr18:51750950 MBD2 0.4 6.27 0.33 1.15e-9 Schizophrenia; CRC cis rs798554 0.797 rs798491 chr7:2800521 A/G cg14895029 chr7:2775587 GNA12 -0.49 -7.05 -0.36 1.07e-11 Height; CRC cis rs17641971 0.662 rs10435575 chr8:49996107 C/T cg00325661 chr8:49890786 NA 0.37 6.29 0.33 1.02e-9 Blood metabolite levels; CRC cis rs17401966 1.000 rs11121552 chr1:10435324 C/A cg19773385 chr1:10388646 KIF1B -0.56 -7.47 -0.38 7.19e-13 Hepatocellular carcinoma; CRC cis rs782590 0.935 rs2586954 chr2:55892261 A/C cg18811423 chr2:55921094 PNPT1 0.8 14.56 0.63 2.12e-37 Metabolic syndrome; CRC cis rs798554 1.000 rs798554 chr7:2759795 C/T cg21192091 chr7:2758800 NA -0.35 -5.79 -0.3 1.61e-8 Height; CRC cis rs3106136 0.843 rs4282187 chr4:95273145 T/C cg11021082 chr4:95130006 SMARCAD1 0.43 6.44 0.33 4.34e-10 Capecitabine sensitivity; CRC cis rs7591163 1.000 rs940341 chr2:228724726 A/G cg21577049 chr2:228736449 WDR69 -0.43 -5.79 -0.3 1.64e-8 Blood pressure; CRC cis rs7618501 0.633 rs4688758 chr3:50028385 G/A cg05623727 chr3:50126028 RBM5 0.46 7.69 0.39 1.76e-13 Intelligence (multi-trait analysis); CRC cis rs4785763 0.570 rs4785759 chr16:90050880 G/T cg25193494 chr16:90016004 DEF8 -0.46 -6.93 -0.36 2.19e-11 Melanoma; CRC cis rs2370759 1.000 rs79442609 chr10:32608749 C/T cg01819863 chr10:32635814 EPC1 1.1 12.91 0.58 3.79e-31 Sexual dysfunction (female); CRC trans rs12495832 0.778 rs78156073 chr3:147898520 C/T cg10221266 chr7:153579447 NA 0.56 6.13 0.32 2.54e-9 Chin dimples; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg05950833 chr1:32688296 C1orf91;EIF3I 0.44 6.16 0.32 2.1e-9 Response to antipsychotic treatment; CRC cis rs7786808 0.615 rs4909212 chr7:158197037 G/T cg17401720 chr7:158221031 PTPRN2 0.38 5.94 0.31 7.34e-9 Obesity-related traits; CRC cis rs6545883 0.868 rs2518932 chr2:61801277 T/A cg15711740 chr2:61764176 XPO1 -0.51 -6.97 -0.36 1.72e-11 Tuberculosis; CRC cis rs8072100 0.713 rs9807106 chr17:45457102 G/T cg25173405 chr17:45401733 C17orf57 -0.46 -6.84 -0.35 3.89e-11 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC trans rs7618501 0.633 rs7621026 chr3:49975334 A/G cg21665057 chr3:196295764 WDR53;FBXO45 0.56 8.93 0.44 3.16e-17 Intelligence (multi-trait analysis); CRC cis rs4713118 0.868 rs7756968 chr6:27734954 C/G cg20933634 chr6:27740509 NA 0.63 7.31 0.37 2e-12 Parkinson's disease; CRC cis rs11577318 0.853 rs12743998 chr1:26629882 G/A cg04990556 chr1:26633338 UBXN11 -0.48 -6.15 -0.32 2.31e-9 Granulocyte percentage of myeloid white cells; CRC cis rs17401966 0.558 rs17402762 chr1:10414470 T/C cg19773385 chr1:10388646 KIF1B -0.47 -7.4 -0.38 1.11e-12 Hepatocellular carcinoma; CRC cis rs7762018 1.000 rs60253563 chr6:170083019 T/C cg19338460 chr6:170058176 WDR27 -0.76 -8.29 -0.42 2.95e-15 Thiazide-induced adverse metabolic effects in hypertensive patients; CRC cis rs11758351 0.660 rs16891443 chr6:26221937 A/C cg08260959 chr6:26240920 HIST1H4F -0.35 -5.6 -0.3 4.44e-8 Gout;Renal underexcretion gout; CRC cis rs6502050 0.835 rs9646397 chr17:80083534 G/A cg02741985 chr17:80059408 CCDC57 -0.44 -7.15 -0.37 5.61e-12 Life satisfaction; CRC cis rs921968 0.541 rs4674308 chr2:219310483 A/C cg02176678 chr2:219576539 TTLL4 0.54 8.67 0.43 2.07e-16 Mean corpuscular hemoglobin concentration; CRC cis rs7677751 0.806 rs7678144 chr4:55102425 T/C cg17187183 chr4:55093834 PDGFRA 0.51 7.55 0.38 4.44e-13 Corneal astigmatism; CRC cis rs2290405 0.593 rs12499663 chr4:888170 G/A cg04824913 chr4:887549 GAK 0.43 6.16 0.32 2.18e-9 Systemic sclerosis; CRC cis rs9322193 0.851 rs9322194 chr6:149920249 C/T cg07701084 chr6:150067640 NUP43 0.57 8.16 0.41 7.04e-15 Lung cancer; CRC cis rs8060686 0.841 rs56374641 chr16:67908713 G/T cg08314208 chr16:67682810 RLTPR -0.62 -7.06 -0.36 9.97e-12 HDL cholesterol;Metabolic syndrome; CRC cis rs763121 0.853 rs5750662 chr22:39072472 G/A cg06022373 chr22:39101656 GTPBP1 0.8 12.62 0.57 4.84e-30 Menopause (age at onset); CRC cis rs9894429 1.000 rs35435780 chr17:79579602 G/T cg13777783 chr17:79615861 NA -0.3 -5.72 -0.3 2.44e-8 Eye color traits; CRC cis rs1707322 0.627 rs3014213 chr1:46045522 T/C cg06784218 chr1:46089804 CCDC17 -0.65 -11.89 -0.55 2.39e-27 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs1218582 0.772 rs2335408 chr1:154915977 G/A cg06221963 chr1:154839813 KCNN3 -0.74 -14.41 -0.62 7.9e-37 Prostate cancer; CRC cis rs734999 0.545 rs28690427 chr1:2571823 A/G cg20673091 chr1:2541236 MMEL1 -0.38 -6.01 -0.31 5.04e-9 Ulcerative colitis; CRC cis rs1707322 0.896 rs785518 chr1:46568422 A/T cg06784218 chr1:46089804 CCDC17 -0.55 -9.67 -0.47 1.26e-19 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs4555082 0.874 rs1882846 chr14:105717448 G/C cg06808227 chr14:105710500 BRF1 -0.62 -9.0 -0.44 1.79e-17 Mean platelet volume;Platelet distribution width; CRC cis rs7772486 0.875 rs9376975 chr6:146355581 T/G cg23711669 chr6:146136114 FBXO30 0.68 11.85 0.55 3.34e-27 Lobe attachment (rater-scored or self-reported); CRC cis rs3859192 0.561 rs12453343 chr17:38181176 C/A cg17344932 chr17:38183730 MED24;SNORD124 0.84 16.62 0.68 1.87e-45 White blood cell count; CRC cis rs9611565 0.659 rs73178641 chr22:41952075 A/T cg06481639 chr22:41940642 POLR3H -0.53 -6.05 -0.32 4.02e-9 Vitiligo; CRC trans rs9914544 0.564 rs9906799 chr17:18795317 A/G cg21372672 chr17:16614065 CCDC144A -0.38 -6.09 -0.32 3.09e-9 Educational attainment (years of education); CRC cis rs1448094 0.511 rs17345272 chr12:86165334 A/C cg00310523 chr12:86230176 RASSF9 0.38 6.1 0.32 3.01e-9 Major depressive disorder; CRC cis rs2786111 0.965 rs1764623 chr1:197288308 G/T cg13682187 chr1:196946512 CFHR5 0.29 5.67 0.3 3.19e-8 Lupus nephritis in systemic lupus erythematosus; CRC cis rs7618915 0.547 rs13064064 chr3:52657002 T/C cg18404041 chr3:52824283 ITIH1 -0.43 -8.83 -0.44 6.25e-17 Bipolar disorder; CRC cis rs10493773 0.510 rs11161645 chr1:86092872 T/C cg17807903 chr1:86174739 ZNHIT6 0.38 8.34 0.42 2.04e-15 Urate levels in overweight individuals; CRC cis rs9811920 0.609 rs13317017 chr3:99665521 A/C cg07805332 chr3:99536008 MIR548G;C3orf26 0.51 7.64 0.39 2.42e-13 Axial length; CRC trans rs7615952 0.546 rs2922171 chr3:125343193 C/T cg07211511 chr3:129823064 LOC729375 -0.62 -7.25 -0.37 3.03e-12 Blood pressure (smoking interaction); CRC cis rs10991814 1.000 rs60953089 chr9:93948053 A/G cg14446406 chr9:93919335 NA 0.51 6.21 0.32 1.64e-9 Neutrophil percentage of granulocytes; CRC cis rs6679356 0.789 rs3977726 chr1:67815915 C/A cg24364144 chr1:67875067 SERBP1 0.43 6.66 0.34 1.14e-10 Primary biliary cholangitis; CRC cis rs6831352 0.819 rs1230155 chr4:99989259 C/T cg12011299 chr4:100065546 ADH4 0.45 9.04 0.45 1.38e-17 Alcohol dependence; CRC cis rs13118159 0.714 rs6843025 chr4:1334418 C/G cg20887711 chr4:1340912 KIAA1530 0.42 5.9 0.31 8.85e-9 Longevity; CRC cis rs9916302 0.904 rs7223438 chr17:37521355 T/C cg07936489 chr17:37558343 FBXL20 0.83 12.75 0.58 1.59e-30 Glomerular filtration rate (creatinine); CRC cis rs7552404 0.924 rs114752222 chr1:76180878 C/T cg03433033 chr1:76189801 ACADM 0.92 14.12 0.61 1.01e-35 Blood metabolite levels;Acylcarnitine levels; CRC cis rs4689388 0.926 rs10937719 chr4:6295322 C/G cg14416269 chr4:6271139 WFS1 0.4 6.43 0.33 4.46e-10 Type 2 diabetes and other traits;Type 2 diabetes; CRC cis rs7618915 0.547 rs33967311 chr3:52683864 G/T cg15147215 chr3:52552868 STAB1 -0.59 -9.6 -0.47 2.06e-19 Bipolar disorder; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg25625872 chr20:62258572 GMEB2 0.45 6.58 0.34 1.83e-10 Anxiety disorder; CRC trans rs2303319 0.504 rs55841284 chr2:162560011 A/G cg03757145 chr4:76555832 CDKL2 -0.65 -6.02 -0.31 4.58e-9 Cognitive function; CRC cis rs8062405 0.755 rs4788073 chr16:28594549 A/G cg16576597 chr16:28551801 NUPR1 0.55 8.11 0.41 1.05e-14 Cognitive ability (multi-trait analysis);Cognitive ability; CRC cis rs9926296 0.605 rs6500449 chr16:89856393 T/C cg03388025 chr16:89894329 SPIRE2 0.4 7.88 0.4 4.85e-14 Vitiligo; CRC cis rs2072499 0.966 rs2253677 chr1:156171296 C/G cg06970220 chr1:156163860 SLC25A44 -0.49 -7.09 -0.36 8.15e-12 Testicular germ cell tumor; CRC trans rs35110281 0.744 rs162395 chr21:44945759 T/C cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.42 6.62 0.34 1.46e-10 Mean corpuscular volume; CRC trans rs2243480 1.000 rs778679 chr7:65840911 A/G cg10756647 chr7:56101905 PSPH 0.78 8.01 0.4 1.97e-14 Diabetic kidney disease; CRC cis rs7727544 0.507 rs11741341 chr5:131570218 A/G cg11843238 chr5:131593191 PDLIM4 0.49 9.02 0.45 1.63e-17 Blood metabolite levels; CRC cis rs9660992 0.573 rs1172139 chr1:205213962 G/A cg03948781 chr1:205179583 DSTYK 0.41 5.61 0.3 4.22e-8 Mean corpuscular volume;Mean platelet volume; CRC cis rs951366 0.789 rs1772148 chr1:205704580 A/T cg26354017 chr1:205819088 PM20D1 0.73 11.0 0.52 3.69e-24 Menarche (age at onset); CRC cis rs951366 0.668 rs823154 chr1:205762406 C/T cg14159672 chr1:205819179 PM20D1 0.85 13.32 0.59 1.15e-32 Menarche (age at onset); CRC cis rs68170813 0.559 rs79564258 chr7:107059803 C/A cg02696742 chr7:106810147 HBP1 -0.6 -6.59 -0.34 1.77e-10 Coronary artery disease; CRC cis rs2295359 0.892 rs12029362 chr1:67624231 G/A cg17031739 chr1:67600172 NA 0.43 6.87 0.35 3.17e-11 Psoriasis; CRC cis rs9858542 0.903 rs35999162 chr3:49597230 C/G cg07274523 chr3:49395745 GPX1 0.48 6.37 0.33 6.23e-10 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs11209185 0.509 rs9436790 chr1:68447044 G/A cg22082780 chr1:68452167 NA 0.4 6.14 0.32 2.36e-9 Itch intensity from mosquito bite adjusted by bite size; CRC cis rs7586879 0.593 rs11689546 chr2:25130451 A/G cg22495460 chr2:25135724 ADCY3 -0.87 -17.43 -0.69 1.16e-48 Body mass index; CRC cis rs9910055 0.659 rs7212573 chr17:42254281 A/G cg10896456 chr17:42255109 ASB16;C17orf65 0.44 7.6 0.39 3.12e-13 Total body bone mineral density; CRC cis rs10028773 0.515 rs9994651 chr4:120587803 C/T cg24375607 chr4:120327624 NA 0.47 7.45 0.38 8.17e-13 Educational attainment; CRC cis rs35146811 0.735 rs1043915 chr7:99799845 T/A cg13334819 chr7:99746414 C7orf59 -0.52 -6.76 -0.35 6.24e-11 Coronary artery disease; CRC cis rs7927771 0.524 rs11039377 chr11:47789776 C/T cg20307385 chr11:47447363 PSMC3 0.46 6.61 0.34 1.52e-10 Subjective well-being; CRC cis rs1046896 1.000 rs1046917 chr17:80685655 A/G cg08200770 chr17:80723486 TBCD 0.42 7.19 0.37 4.25e-12 Glycated hemoglobin levels; CRC cis rs8014671 0.531 rs12880777 chr14:70874695 A/G cg20409590 chr14:70655382 SLC8A3 -0.3 -5.75 -0.3 1.99e-8 Prostate cancer; CRC cis rs6499255 1.000 rs7189424 chr16:69782746 G/A cg04110750 chr16:69646130 NFAT5 -0.51 -6.75 -0.35 6.86e-11 IgE levels; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg24070195 chr17:46969581 ATP5G1 0.44 6.2 0.32 1.74e-9 Response to antipsychotic treatment; CRC cis rs7447593 0.666 rs10866705 chr5:176801131 G/T cg17261708 chr5:176794207 RGS14 -0.53 -8.59 -0.43 3.6e-16 Urinary electrolytes (magnesium/calcium ratio); CRC cis rs17376456 0.877 rs7736620 chr5:93305762 C/T cg21475434 chr5:93447410 FAM172A 0.79 8.19 0.41 5.81e-15 Diabetic retinopathy; CRC cis rs35110281 0.659 rs2236667 chr21:45112939 A/G cg04455712 chr21:45112962 RRP1B 0.42 8.25 0.41 3.73e-15 Mean corpuscular volume; CRC cis rs11585357 0.947 rs2977303 chr1:17611548 A/T cg08277548 chr1:17600880 PADI3 -0.61 -8.61 -0.43 3e-16 Hair shape; CRC cis rs881375 1.000 rs6478486 chr9:123655329 T/C cg09419670 chr9:123605666 PSMD5;LOC253039 0.6 8.83 0.44 6.2e-17 Rheumatoid arthritis; CRC trans rs1814175 0.669 rs17472879 chr11:49499520 G/T cg03929089 chr4:120376271 NA -0.73 -11.88 -0.55 2.6e-27 Height; CRC cis rs17401966 0.838 rs4529713 chr1:10307295 A/G cg19773385 chr1:10388646 KIF1B -0.64 -10.33 -0.49 7.45e-22 Hepatocellular carcinoma; CRC cis rs1838105 0.674 rs10514915 chr17:45166126 C/T cg16759221 chr17:45003025 GOSR2 -0.61 -9.33 -0.46 1.58e-18 Nonsyndromic cleft lip with cleft palate; CRC cis rs9807989 0.839 rs1362348 chr2:102984624 C/G cg03938978 chr2:103052716 IL18RAP 0.37 6.05 0.32 3.99e-9 Asthma; CRC cis rs2617583 0.509 rs4738 chr5:1461568 C/T cg07148919 chr5:1466943 LPCAT1 -0.45 -5.79 -0.3 1.68e-8 Breast cancer; CRC cis rs4065321 0.522 rs3744245 chr17:38146542 C/G cg17344932 chr17:38183730 MED24;SNORD124 0.85 16.8 0.68 3.47e-46 White blood cell count (basophil);White blood cell count; CRC cis rs2249694 1.000 rs2480259 chr10:135352076 A/G cg16964102 chr10:135390573 NA -0.38 -6.15 -0.32 2.29e-9 Obesity-related traits; CRC cis rs11971779 0.648 rs6946113 chr7:139106126 A/C cg23387468 chr7:139079360 LUC7L2 0.41 7.05 0.36 1.04e-11 Diisocyanate-induced asthma; CRC cis rs73206853 0.841 rs73191826 chr12:110943001 G/T cg12870014 chr12:110450643 ANKRD13A 0.76 8.15 0.41 7.69e-15 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC trans rs10838798 0.523 rs11039543 chr11:48168103 G/A cg15704280 chr7:45808275 SEPT13 -0.49 -6.8 -0.35 4.89e-11 Height; CRC cis rs11608355 0.538 rs7305165 chr12:109804222 G/A cg19025524 chr12:109796872 NA -0.59 -9.39 -0.46 9.96e-19 Neuroticism; CRC cis rs9372498 0.536 rs62422227 chr6:118957200 C/G cg18833306 chr6:118973337 C6orf204 0.46 5.88 0.31 1.01e-8 Diastolic blood pressure; CRC cis rs754466 0.606 rs12356375 chr10:79594514 C/A cg17075019 chr10:79541650 NA -0.98 -18.22 -0.71 9.12e-52 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs10791323 0.569 rs2257004 chr11:133712473 C/T cg06766960 chr11:133703094 NA -0.35 -5.76 -0.3 1.9e-8 Childhood ear infection; CRC cis rs801193 0.569 rs11772819 chr7:66217970 T/C cg11764359 chr7:65958608 NA 0.58 8.72 0.43 1.44e-16 Aortic root size; CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg11179286 chr13:115047994 UPF3A 0.42 6.6 0.34 1.63e-10 Obesity-related traits; CRC cis rs34172651 0.517 rs11639856 chr16:24788645 A/T cg02428538 chr16:24856791 SLC5A11 0.6 7.04 0.36 1.1e-11 Intelligence (multi-trait analysis); CRC cis rs1552244 0.882 rs67762674 chr3:10014485 C/T cg16606324 chr3:10149918 C3orf24 0.63 8.21 0.41 5.11e-15 Alzheimer's disease; CRC cis rs853679 0.517 rs9393897 chr6:28127710 G/T cg15786705 chr6:28176104 NA 0.78 9.83 0.48 3.57e-20 Depression; CRC cis rs10504229 0.689 rs17801390 chr8:58054768 T/C cg11062466 chr8:58055876 NA 0.59 7.23 0.37 3.38e-12 Developmental language disorder (linguistic errors); CRC cis rs3806843 0.548 rs246038 chr5:140331699 A/G cg19875535 chr5:140030758 IK 0.4 6.12 0.32 2.64e-9 Depressive symptoms (multi-trait analysis); CRC cis rs1862618 0.853 rs2432195 chr5:56120413 C/T cg18230493 chr5:56204884 C5orf35 -0.7 -9.05 -0.45 1.26e-17 Initial pursuit acceleration; CRC cis rs8005677 1.000 rs4981446 chr14:23381413 A/G cg25600027 chr14:23388339 RBM23 -0.53 -8.37 -0.42 1.65e-15 Cognitive ability (multi-trait analysis); CRC cis rs9549328 0.699 rs2993345 chr13:113617086 C/T cg17524180 chr13:113633600 MCF2L 0.52 9.51 0.46 4.33e-19 Systolic blood pressure; CRC cis rs9462846 0.960 rs12194860 chr6:42862934 C/T cg21280719 chr6:42927975 GNMT -0.31 -5.79 -0.3 1.68e-8 Blood protein levels; CRC cis rs6564851 0.506 rs62054662 chr16:81258173 G/C cg05274606 chr16:81253692 PKD1L2 -0.35 -5.65 -0.3 3.53e-8 Carotenoid and tocopherol levels; CRC cis rs7618915 0.547 rs13065019 chr3:52685244 T/C cg05573699 chr3:52720067 GNL3;PBRM1 -0.47 -6.69 -0.35 9.78e-11 Bipolar disorder; CRC cis rs593982 0.777 rs534414 chr11:65475515 A/G cg08755490 chr11:65554678 OVOL1 0.92 10.13 0.49 3.58e-21 Atopic dermatitis; CRC cis rs10504229 0.953 rs6991035 chr8:58183374 C/T cg05313129 chr8:58192883 C8orf71 -0.47 -6.99 -0.36 1.49e-11 Developmental language disorder (linguistic errors); CRC cis rs4925386 1.000 rs4925389 chr20:60922512 G/A cg15193198 chr20:60906057 LAMA5 0.42 6.82 0.35 4.27e-11 Colorectal cancer;Colorectal cancer (SNP x SNP interaction); CRC trans rs333947 0.800 rs6537885 chr1:110478803 A/G cg22379905 chr12:6601357 MRPL51 -0.47 -6.43 -0.33 4.61e-10 White blood cell count;Monocyte count; CRC cis rs73206853 0.697 rs16934006 chr12:110527907 T/A cg12870014 chr12:110450643 ANKRD13A 0.75 8.93 0.44 3.16e-17 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC cis rs6032067 0.929 rs2143944 chr20:43819370 G/A cg10761708 chr20:43804764 PI3 0.5 5.65 0.3 3.47e-8 Blood protein levels; CRC cis rs1862618 0.573 rs1550821 chr5:56242323 C/T cg20203395 chr5:56204925 C5orf35 0.8 10.06 0.48 6.39e-21 Initial pursuit acceleration; CRC cis rs10504229 0.638 rs6981055 chr8:58113941 T/C cg22535103 chr8:58192502 C8orf71 -0.69 -9.23 -0.45 3.37e-18 Developmental language disorder (linguistic errors); CRC trans rs12663356 0.528 rs9350359 chr6:21462624 C/T cg00777555 chr3:57583074 ARF4 0.41 6.04 0.32 4.16e-9 Crohn's disease; CRC cis rs12692738 0.526 rs366225 chr2:165610236 G/C cg03182029 chr2:165697222 COBLL1 0.5 5.85 0.31 1.16e-8 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);Waist-to-hip ratio adjusted for BMI in non-smokers;Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction);Waist-to-hip ratio adjusted for body mass index; CRC cis rs28374715 1.000 rs28374715 chr15:41563950 A/G cg18705301 chr15:41695430 NDUFAF1 -0.82 -13.21 -0.59 2.88e-32 Ulcerative colitis; CRC cis rs2444240 0.583 rs75389345 chr11:120039924 T/G cg04390734 chr11:120039366 NA 0.29 5.82 0.31 1.43e-8 Corneal curvature; CRC cis rs4664293 0.932 rs4665104 chr2:160532358 C/T cg08347373 chr2:160653686 CD302 -0.37 -6.08 -0.32 3.32e-9 Monocyte percentage of white cells; CRC cis rs968567 0.539 rs174560 chr11:61581764 T/C cg06781209 chr11:61594997 FADS2 -0.43 -6.25 -0.33 1.25e-9 Blood metabolite levels;Rheumatoid arthritis;Vitiligo;Glycerophospholipid levels; CRC cis rs10540 1.000 rs35898083 chr11:484469 C/T cg03352830 chr11:487213 PTDSS2 0.65 7.3 0.37 2.16e-12 Body mass index; CRC cis rs6694672 0.717 rs1537319 chr1:197052804 T/C cg13682187 chr1:196946512 CFHR5 0.48 7.65 0.39 2.3e-13 Asthma; CRC trans rs1005277 0.579 rs2474563 chr10:38375938 T/C cg17830980 chr10:43048298 ZNF37B -0.58 -9.66 -0.47 1.35e-19 Extrinsic epigenetic age acceleration; CRC cis rs28829049 0.536 rs2073106 chr1:19549343 G/C cg22333259 chr1:19394757 NA 0.37 5.7 0.3 2.64e-8 QRS duration in Tripanosoma cruzi seropositivity; CRC cis rs10992471 0.702 rs10820967 chr9:95101729 C/G cg14631576 chr9:95140430 CENPP -0.4 -7.43 -0.38 9.18e-13 Visceral adipose tissue/subcutaneous adipose tissue ratio; CRC cis rs6586163 0.872 rs7082101 chr10:90741615 C/A cg13456138 chr10:90753195 FAS -0.44 -6.58 -0.34 1.84e-10 Chronic lymphocytic leukemia; CRC trans rs10028773 0.556 rs4473640 chr4:120260437 G/A cg25214090 chr10:38739885 LOC399744 0.55 9.0 0.44 1.84e-17 Educational attainment; CRC cis rs7927771 0.524 rs7114813 chr11:47801101 A/G cg20307385 chr11:47447363 PSMC3 0.45 6.57 0.34 1.92e-10 Subjective well-being; CRC cis rs7258465 1.000 rs10411009 chr19:18606266 A/G cg01065977 chr19:18549689 ISYNA1 -0.44 -6.94 -0.36 2.09e-11 Breast cancer; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg07143296 chr11:65383706 PCNXL3 0.41 6.26 0.33 1.21e-9 Intelligence (multi-trait analysis); CRC cis rs7666738 0.830 rs13144564 chr4:98939276 A/G cg17366294 chr4:99064904 C4orf37 0.43 7.32 0.37 1.95e-12 Colonoscopy-negative controls vs population controls; CRC cis rs7781557 0.582 rs2411061 chr7:102613490 T/A cg18108683 chr7:102477205 FBXL13 -0.49 -5.71 -0.3 2.51e-8 Colorectal adenoma (advanced); CRC cis rs56399783 0.614 rs73047355 chr7:2758145 G/A cg19731401 chr7:2775893 GNA12 0.66 6.95 0.36 2.02e-11 Childhood ear infection; CRC cis rs1150668 0.768 rs1233713 chr6:28198281 A/G cg23161317 chr6:28129485 ZNF389 0.37 5.71 0.3 2.58e-8 Pubertal anthropometrics; CRC cis rs4803468 1.000 rs4803465 chr19:41918158 A/G cg09537434 chr19:41945824 ATP5SL 0.92 18.5 0.71 7.09e-53 Height; CRC cis rs4664293 0.967 rs6432548 chr2:160545537 T/C cg08347373 chr2:160653686 CD302 -0.38 -6.19 -0.32 1.83e-9 Monocyte percentage of white cells; CRC cis rs6879260 1.000 rs7730585 chr5:179733440 T/C cg02891314 chr5:179741120 GFPT2 -0.66 -10.13 -0.49 3.56e-21 Height; CRC cis rs904251 1.000 rs904251 chr6:37451696 G/T cg01843034 chr6:37503916 NA -0.38 -6.87 -0.35 3.2e-11 Cognitive performance; CRC cis rs7916697 0.947 rs9783176 chr10:70002393 A/T cg06988349 chr10:69991859 ATOH7 0.32 5.93 0.31 7.6e-9 Optic disc area; CRC cis rs6460942 1.000 rs17668923 chr7:12302873 A/T cg06484146 chr7:12443880 VWDE -0.61 -6.56 -0.34 2.05e-10 Coronary artery disease; CRC cis rs1003719 0.788 rs4816560 chr21:38487561 G/T cg10648535 chr21:38446584 PIGP;TTC3 0.53 7.36 0.38 1.45e-12 Eye color traits; CRC cis rs6717918 0.620 rs7570112 chr2:233150452 A/G ch.2.233013039R chr2:233304795 NA 0.58 7.39 0.38 1.19e-12 Height; CRC cis rs7762018 0.607 rs75521584 chr6:170051595 T/C cg24289452 chr6:170231220 NA -0.92 -7.57 -0.39 3.83e-13 Thiazide-induced adverse metabolic effects in hypertensive patients; CRC cis rs7618501 0.521 rs952594 chr3:49908023 G/A cg21467203 chr3:49911342 NA -0.26 -6.28 -0.33 1.09e-9 Intelligence (multi-trait analysis); CRC cis rs11758351 0.715 rs75390741 chr6:26209784 A/T cg08260959 chr6:26240920 HIST1H4F -0.36 -5.74 -0.3 2.16e-8 Gout;Renal underexcretion gout; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg14771734 chr5:79703670 ZFYVE16 0.42 5.98 0.31 5.93e-9 Response to antipsychotic treatment; CRC cis rs7614311 0.731 rs17401592 chr3:63954490 A/G cg22134162 chr3:63841271 THOC7 -0.57 -5.83 -0.31 1.3e-8 Lung function (FVC);Lung function (FEV1); CRC cis rs861020 0.630 rs585627 chr1:210004199 C/G cg09163369 chr1:210001066 C1orf107 0.41 5.77 0.3 1.85e-8 Orofacial clefts; CRC cis rs1656402 1.000 rs1656397 chr2:233428927 G/C cg03852847 chr2:233439513 NA 0.44 7.56 0.38 4.08e-13 Non-small cell lung cancer (survival); CRC trans rs8002861 0.905 rs12874590 chr13:44433363 C/T cg17145862 chr1:211918768 LPGAT1 -0.68 -12.71 -0.57 2.24e-30 Leprosy; CRC cis rs2836974 0.932 rs6517527 chr21:40581751 G/A cg06238570 chr21:40685208 BRWD1 0.78 10.71 0.51 3.64e-23 Cognitive function; CRC cis rs6762 0.748 rs7936838 chr11:839093 G/C cg07691484 chr11:842764 TSPAN4;POLR2L -0.56 -8.27 -0.41 3.44e-15 Mean platelet volume; CRC cis rs11155671 0.530 rs7768626 chr6:150207962 G/T cg07701084 chr6:150067640 NUP43 0.49 7.17 0.37 4.95e-12 Testicular germ cell tumor; CRC cis rs12760731 0.720 rs1397185 chr1:178381698 G/A cg00404053 chr1:178313656 RASAL2 0.98 10.15 0.49 3.04e-21 Obesity-related traits; CRC cis rs7107174 0.892 rs2512548 chr11:77962116 A/G cg02023728 chr11:77925099 USP35 0.48 7.6 0.39 3.06e-13 Testicular germ cell tumor; CRC cis rs11031096 0.811 rs4910599 chr11:4156040 T/A cg18678763 chr11:4115507 RRM1 -0.42 -7.14 -0.37 5.97e-12 Mean corpuscular volume;Mean corpuscular hemoglobin; CRC cis rs10752881 1.000 rs10797808 chr1:182979623 T/C ch.1.3577855R chr1:183094577 LAMC1 0.87 15.17 0.64 8.98e-40 Colorectal cancer; CRC cis rs3785574 0.962 rs8066463 chr17:61818390 A/G cg25654072 chr17:61904446 PSMC5;FTSJ3 0.42 5.9 0.31 9.27e-9 Height; CRC trans rs1814175 0.791 rs1722023 chr11:49908136 G/C cg21153622 chr11:89784906 NA -0.37 -5.99 -0.31 5.61e-9 Height; CRC cis rs8062405 0.965 rs62037363 chr16:28865042 T/C cg16576597 chr16:28551801 NUPR1 0.48 6.83 0.35 4.14e-11 Cognitive ability (multi-trait analysis);Cognitive ability; CRC cis rs2013441 1.000 rs2013576 chr17:20167692 G/C cg13482628 chr17:19912719 NA -0.4 -6.18 -0.32 1.92e-9 Obesity-related traits; CRC cis rs8005677 1.000 rs4982706 chr14:23381697 C/T cg01529538 chr14:23388837 RBM23 0.4 6.16 0.32 2.14e-9 Cognitive ability (multi-trait analysis); CRC cis rs172166 0.694 rs203876 chr6:28046673 T/C cg03623178 chr6:28175578 NA 0.79 11.69 0.54 1.22e-26 Cardiac Troponin-T levels; CRC cis rs6740322 1.000 rs11693666 chr2:43562479 A/T cg06169590 chr2:43455088 ZFP36L2;LOC100129726 0.55 6.87 0.35 3.22e-11 Coronary artery disease; CRC cis rs1799949 1.000 rs3950989 chr17:41237953 G/A cg19454999 chr17:41278357 BRCA1;NBR2 0.56 8.66 0.43 2.13e-16 Menopause (age at onset); CRC cis rs1865760 0.686 rs12210098 chr6:25963966 C/T cg17691542 chr6:26056736 HIST1H1C 0.51 7.02 0.36 1.27e-11 Height; CRC cis rs9292777 0.776 rs10473190 chr5:40412607 C/A cg09067459 chr5:40385259 NA 0.51 8.91 0.44 3.65e-17 Crohn's disease;Multiple sclerosis; CRC cis rs514406 0.929 rs557847 chr1:53333116 A/G cg27535305 chr1:53392650 SCP2 -0.37 -6.89 -0.36 2.81e-11 Monocyte count; CRC trans rs1455244 0.700 rs7229302 chr18:11508904 G/T cg24153199 chr14:50698328 SOS2 0.4 6.0 0.31 5.3e-9 Schizophrenia; CRC cis rs1799949 1.000 rs11654731 chr17:41326940 G/A cg23758822 chr17:41437982 NA 0.81 13.61 0.6 9.13e-34 Menopause (age at onset); CRC cis rs2991971 0.933 rs2356553 chr1:46009313 G/C cg24296786 chr1:45957014 TESK2 0.52 7.65 0.39 2.24e-13 High light scatter reticulocyte count; CRC cis rs13191362 1.000 rs73035025 chr6:163000988 T/C cg06582575 chr6:163149167 PACRG;PARK2 0.77 10.7 0.51 3.98e-23 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs116095464 0.558 rs11959126 chr5:283880 T/G cg22857025 chr5:266934 NA -1.24 -16.52 -0.67 4.4e-45 Breast cancer; CRC cis rs2949837 0.581 rs2960434 chr7:45972977 A/G cg06713098 chr7:45960367 IGFBP3 0.41 6.51 0.34 2.73e-10 Sitting height ratio; CRC cis rs35146811 0.735 rs1727138 chr7:99815247 A/G cg00553149 chr7:99775558 STAG3;GPC2 -0.24 -5.73 -0.3 2.29e-8 Coronary artery disease; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg06757925 chr1:70671216 LRRC40;SFRS11 0.48 6.32 0.33 8.7e-10 Thyroid stimulating hormone; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg22813821 chr12:72148853 RAB21 0.46 6.26 0.33 1.18e-9 Anxiety disorder; CRC cis rs853679 0.517 rs9380065 chr6:28144751 A/G cg15845792 chr6:28175446 NA 1.04 13.81 0.61 1.6e-34 Depression; CRC cis rs801193 1.000 rs2659915 chr7:66153101 A/G cg18876405 chr7:65276391 NA 0.58 10.65 0.51 5.97e-23 Aortic root size; CRC cis rs1559088 0.576 rs10407255 chr19:33581150 A/G cg27124370 chr19:33622961 WDR88 -0.48 -7.22 -0.37 3.53e-12 Bone ultrasound measurement (broadband ultrasound attenuation); CRC cis rs1005277 0.541 rs2505193 chr10:38394638 G/C cg25427524 chr10:38739819 LOC399744 -0.77 -13.64 -0.6 6.83e-34 Extrinsic epigenetic age acceleration; CRC cis rs8067545 0.750 rs4924805 chr17:19997205 C/G cg13482628 chr17:19912719 NA 0.44 7.06 0.36 9.77e-12 Schizophrenia; CRC cis rs10971721 0.822 rs7856487 chr9:33870940 C/T cg13495928 chr9:33750294 PRSS3 0.54 5.72 0.3 2.41e-8 Body mass index; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg00852613 chr13:50159829 RCBTB1 0.45 7.23 0.37 3.42e-12 Liver disease severity in Alagille syndrome; CRC cis rs11971779 0.715 rs10954646 chr7:139061069 C/G cg07862535 chr7:139043722 LUC7L2 -0.74 -10.07 -0.49 5.92e-21 Diisocyanate-induced asthma; CRC cis rs875971 0.929 rs10950041 chr7:65973875 T/C cg00343986 chr7:65444356 GUSB 0.44 6.47 0.34 3.56e-10 Aortic root size; CRC cis rs853679 0.517 rs12332979 chr6:28141548 T/G cg23161317 chr6:28129485 ZNF389 0.54 6.47 0.34 3.49e-10 Depression; CRC cis rs1707322 1.000 rs4660895 chr1:46329739 C/T cg03146154 chr1:46216737 IPP 0.5 6.97 0.36 1.7e-11 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs1048238 0.846 rs945417 chr1:16344625 C/G cg22431228 chr1:16359049 CLCNKA -0.43 -8.31 -0.42 2.53e-15 Systolic blood pressure; CRC cis rs1165205 0.558 rs531750 chr6:25882642 C/G cg15691649 chr6:25882328 NA -0.5 -6.7 -0.35 8.87e-11 Urate levels; CRC cis rs3749237 0.555 rs2117939 chr3:49415179 C/A cg02487422 chr3:49467188 NICN1 0.44 7.11 0.36 7.49e-12 Resting heart rate; CRC cis rs7772486 0.875 rs11755334 chr6:146399297 T/C cg23711669 chr6:146136114 FBXO30 0.64 11.21 0.53 6.42e-25 Lobe attachment (rater-scored or self-reported); CRC cis rs763121 0.853 rs5757231 chr22:39071658 C/T cg06544989 chr22:39130855 UNC84B -0.45 -6.83 -0.35 4.07e-11 Menopause (age at onset); CRC trans rs113835537 0.627 rs4630309 chr11:66333072 A/C cg02891801 chr12:6472782 SCNN1A 0.61 6.41 0.33 5.12e-10 Airway imaging phenotypes; CRC cis rs7605827 0.930 rs6733519 chr2:15525567 T/C cg19274914 chr2:15703543 NA 0.38 5.63 0.3 3.81e-8 Educational attainment (years of education); CRC cis rs9435341 0.965 rs12401598 chr1:107580533 C/A cg14828511 chr1:107599125 PRMT6 0.55 7.49 0.38 6.37e-13 Facial morphology (factor 21, depth of nasal alae); CRC trans rs3749237 0.929 rs62260715 chr3:49829326 G/A cg21659725 chr3:3221576 CRBN 0.55 7.45 0.38 8.53e-13 Resting heart rate; CRC trans rs208520 0.874 rs208473 chr6:66917265 G/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.91 -11.82 -0.55 3.98e-27 Exhaled nitric oxide output; CRC cis rs10540 0.841 rs35601764 chr11:532923 A/C cg08200582 chr11:442649 ANO9 -0.69 -7.04 -0.36 1.16e-11 Body mass index; CRC cis rs7208859 0.673 rs216420 chr17:28938508 C/T cg19761014 chr17:28927070 LRRC37B2 0.55 6.45 0.34 3.95e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs7394190 0.688 rs3812629 chr10:75407290 G/A cg07699608 chr10:75541558 CHCHD1 0.62 6.35 0.33 6.95e-10 Incident atrial fibrillation; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg18172804 chr1:146714232 CHD1L 0.44 6.25 0.33 1.3e-9 Anxiety disorder; CRC cis rs7849270 1.000 rs7023900 chr9:131891152 C/G cg13538475 chr9:131942899 NA -0.31 -6.03 -0.32 4.33e-9 Blood metabolite ratios; CRC cis rs13191362 1.000 rs34192365 chr6:163012382 T/G cg23758597 chr6:163146217 PARK2 -0.56 -6.17 -0.32 2.03e-9 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs7216064 1.000 rs9912770 chr17:65868233 C/T cg12091567 chr17:66097778 LOC651250 -0.62 -7.85 -0.4 6.07e-14 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CRC cis rs898097 0.812 rs56405605 chr17:80843663 T/C cg16060761 chr17:80687452 NA 0.42 6.0 0.31 5.21e-9 Breast cancer; CRC cis rs10493773 0.609 rs10873716 chr1:86178347 G/T cg00734567 chr1:86172782 ZNHIT6 -0.48 -7.26 -0.37 2.79e-12 Urate levels in overweight individuals; CRC cis rs7584330 0.868 rs2325839 chr2:238386286 T/C cg16989719 chr2:238392110 NA -0.47 -9.26 -0.45 2.65e-18 Prostate cancer; CRC cis rs4474465 1.000 rs6592780 chr11:78199888 C/G cg27205649 chr11:78285834 NARS2 -0.47 -5.79 -0.3 1.61e-8 Alzheimer's disease (survival time); CRC cis rs798554 0.679 rs11973498 chr7:2886873 C/A cg13628971 chr7:2884303 GNA12 0.62 8.94 0.44 2.94e-17 Height; CRC cis rs7772486 0.875 rs10457794 chr6:146415608 A/G cg13319975 chr6:146136371 FBXO30 -0.4 -6.17 -0.32 2.05e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs853679 0.527 rs707907 chr6:28291240 A/G cg15845792 chr6:28175446 NA 0.45 6.24 0.33 1.35e-9 Depression; CRC cis rs4713118 0.662 rs149969 chr6:27977737 A/G cg23161317 chr6:28129485 ZNF389 0.43 5.9 0.31 9.23e-9 Parkinson's disease; CRC cis rs7178572 1.000 rs6495240 chr15:77766556 T/C cg22256960 chr15:77711686 NA -0.7 -10.84 -0.51 1.34e-23 Type 2 diabetes; CRC cis rs9291683 0.595 rs10939665 chr4:10037628 T/C cg11266682 chr4:10021025 SLC2A9 0.53 11.08 0.52 1.85e-24 Bone mineral density; CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg23850377 chr2:20251576 LAPTM4A -0.53 -6.45 -0.34 3.92e-10 Diisocyanate-induced asthma; CRC cis rs919433 0.963 rs4850428 chr2:198169772 G/A cg10820045 chr2:198174542 NA -0.56 -9.64 -0.47 1.62e-19 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC cis rs9902453 0.845 rs2259855 chr17:28097860 T/C cg26525008 chr17:28256777 EFCAB5;SSH2 -0.59 -8.78 -0.44 9.2e-17 Coffee consumption (cups per day); CRC cis rs4689388 0.819 rs12649341 chr4:6294759 G/A cg25554036 chr4:6271136 WFS1 0.53 8.7 0.43 1.59e-16 Type 2 diabetes and other traits;Type 2 diabetes; CRC cis rs4654899 0.758 rs6426665 chr1:21382205 T/C cg11157611 chr1:21499906 EIF4G3 0.32 5.6 0.3 4.47e-8 Superior frontal gyrus grey matter volume; CRC cis rs2739330 0.789 rs5760109 chr22:24252938 C/G cg10819733 chr22:24237672 NA -0.35 -6.06 -0.32 3.7e-9 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs427941 0.632 rs382228 chr7:101786064 A/C cg06246474 chr7:101738831 CUX1 0.43 6.59 0.34 1.79e-10 Plasma omega-3 polyunsaturated fatty acid level (eicosapentaenoic acid); CRC cis rs11585357 0.895 rs72633808 chr1:17618665 A/G cg08277548 chr1:17600880 PADI3 -0.88 -11.25 -0.53 4.66e-25 Hair shape; CRC cis rs735396 0.694 rs2264750 chr12:121450165 C/T cg02403541 chr12:121454288 C12orf43 0.49 7.16 0.37 5.28e-12 N-glycan levels; CRC cis rs2976388 0.566 rs4736373 chr8:143792357 G/C cg12516270 chr8:143859308 LYNX1 -0.42 -6.84 -0.35 3.78e-11 Urinary tract infection frequency; CRC cis rs4713118 0.513 rs149989 chr6:27998184 T/A cg03623178 chr6:28175578 NA 0.77 11.68 0.54 1.3e-26 Parkinson's disease; CRC cis rs10876993 0.890 rs4760165 chr12:58063801 C/T cg18357645 chr12:58087776 OS9 0.59 8.01 0.4 1.95e-14 Celiac disease or Rheumatoid arthritis; CRC cis rs9811920 0.609 rs9872871 chr3:99658702 C/G cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G -0.46 -6.18 -0.32 1.91e-9 Axial length; CRC cis rs4665809 0.590 rs1560865 chr2:26452197 C/A cg26119090 chr2:26468346 HADHA;HADHB -1.0 -14.65 -0.63 8.89e-38 Gut microbiome composition (summer); CRC cis rs10479542 0.583 rs4131080 chr5:179044292 G/A cg21226059 chr5:178986404 RUFY1 0.35 5.85 0.31 1.21e-8 Lung cancer; CRC cis rs6901250 0.851 rs339362 chr6:117165370 A/C cg12892004 chr6:117198278 RFX6 -0.43 -6.76 -0.35 6.21e-11 C-reactive protein levels; CRC cis rs10504229 1.000 rs17805326 chr8:58169533 A/C cg22535103 chr8:58192502 C8orf71 -0.82 -12.29 -0.56 8.15e-29 Developmental language disorder (linguistic errors); CRC cis rs9486719 1.000 rs2499807 chr6:96864053 T/G cg06623918 chr6:96969491 KIAA0776 0.81 9.48 0.46 5.18e-19 Migraine;Coronary artery disease; CRC trans rs5756813 0.754 rs11089854 chr22:38148882 G/A cg19894588 chr14:64061835 NA -0.6 -8.13 -0.41 8.7e-15 Optic cup area;Vertical cup-disc ratio; CRC cis rs4481887 0.790 rs6587440 chr1:248415662 A/G cg13385794 chr1:248469461 NA 0.33 5.84 0.31 1.27e-8 Common traits (Other); CRC cis rs7635838 0.892 rs7644968 chr3:11489493 C/T cg00170343 chr3:11313890 ATG7 0.41 6.32 0.33 8.7e-10 HDL cholesterol; CRC cis rs7829975 0.514 rs2979151 chr8:8258019 A/G cg08975724 chr8:8085496 FLJ10661 -0.5 -7.52 -0.38 5.24e-13 Mood instability; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg07886860 chr3:40566285 ZNF621 0.42 6.39 0.33 5.65e-10 Intelligence (multi-trait analysis); CRC cis rs2842992 0.789 rs4709370 chr6:160210061 A/G cg16489826 chr6:160211363 TCP1;MRPL18 0.5 6.27 0.33 1.11e-9 Age-related macular degeneration (geographic atrophy); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg11609344 chr7:44240862 YKT6 0.46 6.8 0.35 4.94e-11 Intelligence (multi-trait analysis); CRC cis rs10504229 0.679 rs73681882 chr8:58030038 A/G cg02725872 chr8:58115012 NA -0.34 -5.65 -0.3 3.44e-8 Developmental language disorder (linguistic errors); CRC cis rs4891159 0.790 rs17059325 chr18:74119567 A/C cg24786174 chr18:74118243 ZNF516 -0.86 -15.02 -0.64 3.52e-39 Longevity; CRC cis rs2985684 1.000 rs2985696 chr14:50094913 C/A cg04989706 chr14:50066350 PPIL5 -0.54 -7.45 -0.38 8.18e-13 Carotid intima media thickness; CRC cis rs2180341 0.781 rs7742161 chr6:127571676 T/C cg24812749 chr6:127587940 RNF146 0.72 10.65 0.51 5.78e-23 Breast cancer; CRC trans rs11098499 0.955 rs35197422 chr4:120169314 T/G cg25214090 chr10:38739885 LOC399744 0.51 7.88 0.4 4.77e-14 Corneal astigmatism; CRC cis rs17376456 0.877 rs10070390 chr5:93452345 G/A cg09848695 chr5:92956644 FAM172A;MIR2277 0.63 6.14 0.32 2.37e-9 Diabetic retinopathy; CRC cis rs2361718 0.500 rs4889970 chr17:78096086 C/T cg21238619 chr17:78079768 GAA 0.45 7.04 0.36 1.1e-11 Yeast infection; CRC cis rs2239547 0.522 rs7652131 chr3:52997154 C/T cg18404041 chr3:52824283 ITIH1 -0.36 -6.76 -0.35 6.2e-11 Schizophrenia; CRC cis rs1707322 0.721 rs9793568 chr1:46130373 G/A cg03146154 chr1:46216737 IPP 0.67 9.75 0.47 6.98e-20 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs6952808 0.689 rs58227534 chr7:2046328 A/G cg21782813 chr7:2030301 MAD1L1 0.55 9.49 0.46 4.78e-19 Bipolar disorder and schizophrenia; CRC cis rs7615952 0.673 rs9289270 chr3:125636979 A/T cg05084668 chr3:125655381 ALG1L -0.84 -10.45 -0.5 3.01e-22 Blood pressure (smoking interaction); CRC cis rs10504229 1.000 rs61733801 chr8:58192513 A/G cg02290350 chr8:58132656 NA -0.42 -5.96 -0.31 6.62e-9 Developmental language disorder (linguistic errors); CRC cis rs68170813 0.523 rs111590023 chr7:107055323 T/C cg02696742 chr7:106810147 HBP1 -0.53 -5.93 -0.31 7.69e-9 Coronary artery disease; CRC cis rs72781680 0.611 rs72797819 chr2:24351141 T/G cg20701182 chr2:24300061 SF3B14 0.66 7.83 0.4 6.69e-14 Lymphocyte counts; CRC cis rs4683142 0.518 rs6802312 chr3:46025941 T/C cg08033130 chr3:45983597 CXCR6;FYCO1 0.41 5.65 0.3 3.4e-8 Methadone dose in opioid dependence; CRC cis rs8062405 0.755 rs4788076 chr16:28570005 C/T cg16576597 chr16:28551801 NUPR1 0.56 8.37 0.42 1.66e-15 Cognitive ability (multi-trait analysis);Cognitive ability; CRC cis rs12458462 0.892 rs2242175 chr18:77464406 G/A cg11879182 chr18:77439856 CTDP1 0.71 11.13 0.52 1.24e-24 Monocyte count; CRC cis rs7772486 0.754 rs1055212 chr6:146058315 A/T cg05347473 chr6:146136440 FBXO30 -0.38 -5.78 -0.3 1.71e-8 Lobe attachment (rater-scored or self-reported); CRC cis rs12477438 0.520 rs13035311 chr2:99717322 C/G cg14399236 chr2:99771627 LIPT1;TSGA10 0.78 13.69 0.6 4.36e-34 Chronic sinus infection; CRC cis rs6951245 0.872 rs75493422 chr7:1072890 C/T cg20603222 chr7:1096387 C7orf50;GPR146 -0.7 -8.14 -0.41 8.5e-15 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs12711979 0.509 rs13000873 chr2:3823705 T/C cg17052675 chr2:3827356 NA -0.86 -21.11 -0.76 3.77e-63 Itch intensity from mosquito bite adjusted by bite size; CRC cis rs10504229 0.593 rs75047131 chr8:58001320 A/G cg24829409 chr8:58192753 C8orf71 -0.52 -6.38 -0.33 5.87e-10 Developmental language disorder (linguistic errors); CRC cis rs11155671 0.530 rs1334510 chr6:150201179 A/G cg05861140 chr6:150128134 PCMT1 -0.35 -5.63 -0.3 3.81e-8 Testicular germ cell tumor; CRC cis rs67311347 1.000 rs7634375 chr3:40431946 C/T cg09455208 chr3:40491958 NA 0.48 9.13 0.45 7.17e-18 Renal cell carcinoma; CRC cis rs886126 0.684 rs3858704 chr12:111705893 A/G cg10833066 chr12:111807467 FAM109A 0.42 6.12 0.32 2.68e-9 Coronary heart disease; CRC cis rs7666738 0.830 rs13125930 chr4:98654695 G/A cg05340658 chr4:99064831 C4orf37 0.56 8.43 0.42 1.12e-15 Colonoscopy-negative controls vs population controls; CRC cis rs40363 0.645 rs250633 chr16:3523002 C/T cg22508957 chr16:3507546 NAT15 0.59 9.25 0.45 2.93e-18 Tuberculosis; CRC cis rs12824058 0.831 rs4759452 chr12:130812799 G/A cg26677194 chr12:130822605 PIWIL1 0.45 7.18 0.37 4.53e-12 Menopause (age at onset); CRC cis rs2657888 0.628 rs3809122 chr12:56882710 A/T cg23002907 chr12:56915593 RBMS2 -0.39 -6.23 -0.32 1.46e-9 Adiponectin levels; CRC cis rs919433 0.713 rs1455653 chr2:198478320 G/A cg10820045 chr2:198174542 NA 0.42 7.34 0.38 1.71e-12 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC cis rs875971 0.862 rs937494 chr7:65764678 T/A cg18876405 chr7:65276391 NA -0.5 -8.31 -0.42 2.49e-15 Aortic root size; CRC cis rs3764400 0.567 rs2240120 chr17:46142144 C/T cg10706073 chr17:46328419 SKAP1 -0.64 -6.85 -0.35 3.69e-11 Body mass index; CRC cis rs6582630 0.537 rs2204006 chr12:38407098 A/G cg13010199 chr12:38710504 ALG10B 0.47 6.4 0.33 5.43e-10 Drug-induced liver injury (flucloxacillin); CRC cis rs11098499 0.913 rs68128210 chr4:120137819 T/G cg09307838 chr4:120376055 NA 0.59 8.79 0.44 8.19e-17 Corneal astigmatism; CRC cis rs4713118 0.869 rs6922574 chr6:27693003 A/T cg21204522 chr6:27730016 NA -0.41 -5.79 -0.3 1.6e-8 Parkinson's disease; CRC cis rs9322193 0.923 rs9767105 chr6:149980727 A/G cg00933542 chr6:150070202 PCMT1 0.32 6.66 0.34 1.18e-10 Lung cancer; CRC cis rs7727544 0.669 rs113823725 chr5:131563501 C/G cg22638593 chr5:131593259 PDLIM4 0.35 6.47 0.34 3.59e-10 Blood metabolite levels; CRC trans rs7618501 0.519 rs3774750 chr3:50208406 C/G cg21665057 chr3:196295764 WDR53;FBXO45 -0.49 -7.65 -0.39 2.24e-13 Intelligence (multi-trait analysis); CRC cis rs11212617 0.840 rs10890849 chr11:108363755 C/T cg14761454 chr11:108092087 ATM;NPAT 0.39 5.75 0.3 2.01e-8 Response to metformin in type 2 diabetes (glycemic); CRC trans rs11581859 0.950 rs72730315 chr1:99380147 C/T cg12183875 chr3:169587454 LRRC31 0.28 6.27 0.33 1.14e-9 Response to cognitive-behavioural therapy in anxiety disorder; CRC cis rs6088580 0.668 rs1205337 chr20:32926041 T/A cg08999081 chr20:33150536 PIGU -0.64 -12.06 -0.55 5.47e-28 Glomerular filtration rate (creatinine); CRC cis rs478304 0.900 rs502468 chr11:65525119 T/G cg08755490 chr11:65554678 OVOL1 0.44 6.34 0.33 7.57e-10 Acne (severe); CRC cis rs7727544 0.642 rs7705189 chr5:131623358 C/T cg04518342 chr5:131593106 PDLIM4 -0.33 -5.86 -0.31 1.11e-8 Blood metabolite levels; CRC cis rs2842992 0.915 rs2842985 chr6:160085434 C/T cg19482086 chr6:160211437 TCP1;MRPL18 0.73 8.89 0.44 4.13e-17 Age-related macular degeneration (geographic atrophy); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg23808061 chr1:179923593 CEP350 0.45 6.31 0.33 9.16e-10 Response to antipsychotic treatment; CRC cis rs1552244 1.000 rs6782602 chr3:10116541 G/T cg18598329 chr3:10140678 FANCD2;C3orf24 -0.89 -12.69 -0.57 2.6e-30 Alzheimer's disease; CRC cis rs13108904 0.557 rs1250086 chr4:1248051 G/A cg02018176 chr4:1364513 KIAA1530 -0.6 -9.66 -0.47 1.36e-19 Obesity-related traits; CRC cis rs713587 0.563 rs7605335 chr2:25109317 G/A cg22495460 chr2:25135724 ADCY3 -0.88 -17.7 -0.7 9.95e-50 Body mass index in non-asthmatics; CRC cis rs6748734 0.779 rs4401206 chr2:241796905 A/G cg16358738 chr2:241808595 AGXT -0.4 -6.25 -0.33 1.24e-9 Urinary metabolites; CRC cis rs11098499 0.754 rs12513083 chr4:120249612 A/T cg09307838 chr4:120376055 NA 0.61 9.59 0.47 2.22e-19 Corneal astigmatism; CRC cis rs4481887 0.741 rs6587471 chr1:248560741 C/T cg00666640 chr1:248458726 OR2T12 0.4 7.33 0.37 1.83e-12 Common traits (Other); CRC cis rs10504229 1.000 rs59797486 chr8:58174435 T/C cg05313129 chr8:58192883 C8orf71 -0.45 -7.05 -0.36 1.09e-11 Developmental language disorder (linguistic errors); CRC cis rs9325144 0.555 rs2387847 chr12:38687434 C/T cg13010199 chr12:38710504 ALG10B 0.41 6.02 0.32 4.61e-9 Morning vs. evening chronotype; CRC cis rs1065656 0.553 rs344357 chr16:1836255 C/G cg09830162 chr16:1889614 FAHD1;C16orf73 -0.5 -6.35 -0.33 7.1e-10 Insulin-like growth factors; CRC cis rs2624839 0.704 rs14321 chr3:50226151 T/C cg24110177 chr3:50126178 RBM5 0.42 5.73 0.3 2.22e-8 Intelligence (multi-trait analysis); CRC cis rs651907 0.557 rs11914318 chr3:101453858 C/T cg12386194 chr3:101231763 SENP7 0.5 7.37 0.38 1.42e-12 Colorectal cancer; CRC cis rs2742417 1.000 rs2742385 chr3:45756270 G/A cg04837898 chr3:45731254 SACM1L -0.37 -6.03 -0.32 4.38e-9 Response to anti-depressant treatment in major depressive disorder; CRC cis rs2386661 0.591 rs11255051 chr10:5653450 A/G cg17085576 chr10:5658249 NA -0.44 -6.37 -0.33 6.21e-10 Breast cancer; CRC cis rs13108904 0.870 rs4974542 chr4:1250908 A/G cg05665937 chr4:1216051 CTBP1 0.43 6.44 0.33 4.34e-10 Obesity-related traits; CRC cis rs875971 0.545 rs7810213 chr7:65946579 G/C cg03233332 chr7:66118400 NA -0.41 -5.6 -0.3 4.51e-8 Aortic root size; CRC cis rs4722166 0.541 rs1800795 chr7:22766645 C/G cg05472934 chr7:22766657 IL6 0.78 13.26 0.59 1.95e-32 Lung cancer; CRC cis rs72945132 0.825 rs947811 chr11:70209142 A/T cg00319359 chr11:70116639 PPFIA1 0.55 5.88 0.31 1.03e-8 Coronary artery disease; CRC cis rs6831352 0.918 rs29001209 chr4:100052340 C/A cg12011299 chr4:100065546 ADH4 -0.49 -9.27 -0.45 2.61e-18 Alcohol dependence; CRC cis rs3790844 0.746 rs3790850 chr1:200005193 C/G cg07208853 chr1:200005219 NR5A2 0.36 8.86 0.44 5.09e-17 Pancreatic cancer; CRC cis rs7811142 1.000 rs7783159 chr7:100017454 C/T cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.73 9.56 0.47 2.97e-19 Platelet count; CRC cis rs1707322 1.000 rs1588663 chr1:46548825 G/A cg06784218 chr1:46089804 CCDC17 -0.55 -9.67 -0.47 1.26e-19 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs6598955 0.617 rs11247883 chr1:26576247 T/G cg04990556 chr1:26633338 UBXN11 0.56 6.02 0.32 4.53e-9 Obesity-related traits; CRC cis rs2688608 0.530 rs71507081 chr10:75493136 G/A cg16540259 chr10:75572220 NDST2 0.38 5.91 0.31 8.5e-9 Inflammatory bowel disease; CRC cis rs315934 0.621 rs2121326 chr2:113846975 C/G cg24553058 chr2:113831203 IL1F10 0.48 5.69 0.3 2.85e-8 Dysmenorrheic pain; CRC trans rs7613875 0.620 rs7624030 chr3:50071279 A/C cg21665057 chr3:196295764 WDR53;FBXO45 -0.43 -6.32 -0.33 8.37e-10 Body mass index; CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg10137990 chr8:145137203 GPAA1 0.35 6.0 0.31 5.29e-9 Obesity-related traits; CRC cis rs1185460 0.967 rs1786690 chr11:118942067 A/G cg23280166 chr11:118938394 VPS11 0.4 6.01 0.31 4.79e-9 Coronary artery disease; CRC cis rs7095944 0.582 rs10901823 chr10:126488660 C/T cg08799069 chr10:126477246 METTL10 -0.44 -6.86 -0.35 3.46e-11 Asthma; CRC cis rs7178572 0.568 rs12906708 chr15:77681444 A/G cg22256960 chr15:77711686 NA -0.66 -9.6 -0.47 2.13e-19 Type 2 diabetes; CRC cis rs208520 0.874 rs208515 chr6:66945749 A/G cg07460842 chr6:66804631 NA -0.96 -12.38 -0.56 3.67e-29 Exhaled nitric oxide output; CRC cis rs7615952 0.688 rs12485622 chr3:125710739 T/C cg04553112 chr3:125709451 NA -0.49 -5.81 -0.3 1.49e-8 Blood pressure (smoking interaction); CRC cis rs79387448 0.745 rs59126438 chr2:103165142 T/G cg00507830 chr2:103233733 NA 0.52 5.77 0.3 1.81e-8 Gut microbiota (bacterial taxa); CRC cis rs1997103 0.863 rs6956287 chr7:55415107 T/C cg17469321 chr7:55412551 NA 0.72 10.79 0.51 1.87e-23 QRS interval (sulfonylurea treatment interaction); CRC cis rs1552244 0.766 rs34232505 chr3:10186216 T/A cg08888203 chr3:10149979 C3orf24 0.68 9.09 0.45 9.46e-18 Alzheimer's disease; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg20766702 chr5:102594493 C5orf30 0.45 6.36 0.33 6.86e-10 Anxiety disorder; CRC cis rs9649213 0.574 rs17436977 chr7:97883459 T/C cg24562669 chr7:97807699 LMTK2 0.5 8.5 0.42 6.53e-16 Prostate cancer (SNP x SNP interaction); CRC cis rs2050392 0.517 rs2489847 chr10:30743673 G/A cg18806716 chr10:30721971 MAP3K8 -0.59 -8.33 -0.42 2.21e-15 Inflammatory bowel disease; CRC cis rs6662572 0.737 rs7555458 chr1:46554142 A/G cg03123370 chr1:45965343 CCDC163P;MMACHC 0.48 6.21 0.32 1.57e-9 Blood protein levels; CRC cis rs2075371 0.932 rs1035328 chr7:133978419 T/C cg11752832 chr7:134001865 SLC35B4 0.49 7.64 0.39 2.35e-13 Mean platelet volume; CRC cis rs526631 0.564 rs10896051 chr11:65578759 C/T cg26695010 chr11:65641043 EFEMP2 0.49 7.46 0.38 7.68e-13 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; CRC trans rs3851050 0.704 rs7901131 chr10:81873327 T/A cg16857335 chr19:47633940 SAE1 0.48 6.26 0.33 1.23e-9 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs208520 0.661 rs150263 chr6:66777620 T/C cg07460842 chr6:66804631 NA -1.05 -14.72 -0.63 5.16e-38 Exhaled nitric oxide output; CRC cis rs72634258 0.945 rs4908724 chr1:8119251 G/T cg00042356 chr1:8021962 PARK7 0.67 7.13 0.37 6.42e-12 Inflammatory bowel disease; CRC cis rs9547692 0.938 rs12427600 chr13:37460648 C/T cg01493522 chr13:37497338 NA 0.55 7.54 0.38 4.62e-13 Coronary artery disease; CRC cis rs9611565 0.918 rs6002351 chr22:41757223 C/T cg03806693 chr22:41940476 POLR3H -0.73 -10.53 -0.5 1.55e-22 Vitiligo; CRC cis rs9372498 0.536 rs10484286 chr6:118956447 T/C cg01339444 chr6:118972232 C6orf204 0.56 6.09 0.32 3.14e-9 Diastolic blood pressure; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg26851410 chr19:2785307 THOP1 0.43 5.97 0.31 6.07e-9 Response to antipsychotic treatment; CRC cis rs9291683 0.595 rs13150928 chr4:10052961 G/T cg11266682 chr4:10021025 SLC2A9 0.52 10.81 0.51 1.64e-23 Bone mineral density; CRC cis rs2859741 0.587 rs580029 chr1:37471609 C/A cg09363841 chr1:37513479 NA -0.51 -8.8 -0.44 7.78e-17 Forced expiratory volume in 1 second (environmental tobacco smoke interaction); CRC cis rs2228479 0.867 rs35542367 chr16:89965825 G/C cg12064134 chr16:90016061 DEF8 -0.6 -5.63 -0.3 3.83e-8 Skin colour saturation; CRC cis rs2354432 0.556 rs7525622 chr1:146774116 G/A cg25205988 chr1:146714368 CHD1L -1.16 -9.52 -0.46 3.9e-19 Mitochondrial DNA levels; CRC cis rs35306767 0.903 rs35567307 chr10:915804 G/C cg20503657 chr10:835505 NA 0.98 12.38 0.56 3.74e-29 Eosinophil percentage of granulocytes; CRC cis rs1552244 0.935 rs11926481 chr3:10142102 G/T cg16606324 chr3:10149918 C3orf24 0.69 9.6 0.47 2.1e-19 Alzheimer's disease; CRC trans rs17685 0.753 rs13240404 chr7:75675719 C/T cg19862616 chr7:65841803 NCRNA00174 -0.99 -18.5 -0.71 7.22e-53 Coffee consumption;Coffee consumption (cups per day); CRC cis rs875971 0.508 rs10253883 chr7:66061138 T/C cg00343986 chr7:65444356 GUSB -0.47 -7.07 -0.36 9.5e-12 Aortic root size; CRC cis rs11212617 0.902 rs11212546 chr11:108064935 A/G cg14761454 chr11:108092087 ATM;NPAT 0.38 5.67 0.3 3.1e-8 Response to metformin in type 2 diabetes (glycemic); CRC cis rs6951245 0.872 rs75493422 chr7:1072890 C/T cg04025307 chr7:1156635 C7orf50 0.63 6.66 0.34 1.18e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC trans rs6472235 0.837 rs60020249 chr8:66928647 C/T cg07884673 chr3:53033167 SFMBT1 -0.45 -6.03 -0.32 4.47e-9 Myopia (pathological);Plateletcrit; CRC trans rs3733585 0.699 rs7676733 chr4:9966956 G/A cg26043149 chr18:55253948 FECH -0.49 -7.51 -0.38 5.78e-13 Cleft plate (environmental tobacco smoke interaction); CRC cis rs7666738 0.830 rs6532721 chr4:99048015 G/A cg17366294 chr4:99064904 C4orf37 0.45 7.75 0.39 1.16e-13 Colonoscopy-negative controls vs population controls; CRC cis rs3741151 0.686 rs7938391 chr11:73221957 A/G cg17517138 chr11:73019481 ARHGEF17 0.54 5.85 0.31 1.2e-8 GIP levels in response to oral glucose tolerance test (120 minutes); CRC cis rs853679 0.517 rs11552219 chr6:28126834 C/T cg25164649 chr6:28176230 NA 0.78 9.66 0.47 1.33e-19 Depression; CRC cis rs172166 0.769 rs149965 chr6:28018689 T/A cg21251018 chr6:28226885 NKAPL 0.48 7.48 0.38 6.95e-13 Cardiac Troponin-T levels; CRC cis rs1538970 0.816 rs11211123 chr1:45957609 G/A cg05343316 chr1:45956843 TESK2 0.75 9.79 0.48 4.94e-20 Platelet count; CRC cis rs1448094 0.512 rs4488288 chr12:86245450 A/C cg02569458 chr12:86230093 RASSF9 0.42 7.24 0.37 3.17e-12 Major depressive disorder; CRC cis rs6942756 1.000 rs11769045 chr7:128895335 A/G cg02491457 chr7:128862824 NA -0.77 -10.6 -0.5 9.16e-23 White matter hyperintensity burden; CRC trans rs10983614 1.000 rs7867776 chr9:120072627 A/G cg17079137 chr17:27070735 TRAF4 0.45 6.11 0.32 2.77e-9 Survival in pancreatic cancer; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg01272601 chr2:69871685 AAK1 0.47 6.65 0.34 1.24e-10 Response to antipsychotic treatment; CRC cis rs1799949 1.000 rs1135214 chr17:41292323 T/C cg19454999 chr17:41278357 BRCA1;NBR2 0.54 8.28 0.42 3.06e-15 Menopause (age at onset); CRC cis rs9303280 0.901 rs1008723 chr17:38066267 G/T cg00129232 chr17:37814104 STARD3 -0.46 -7.31 -0.37 2.09e-12 Self-reported allergy; CRC cis rs35110281 0.667 rs7282122 chr21:45082365 G/A cg04455712 chr21:45112962 RRP1B 0.41 7.96 0.4 2.86e-14 Mean corpuscular volume; CRC cis rs2760061 0.583 rs1745413 chr1:228212456 A/G cg02753203 chr1:228287806 NA 0.95 14.3 0.62 2.16e-36 Diastolic blood pressure; CRC cis rs2832191 0.671 rs68101501 chr21:30513229 G/T cg24692254 chr21:30365293 RNF160 -0.57 -8.4 -0.42 1.37e-15 Dental caries; CRC cis rs4654899 0.965 rs4654907 chr1:21521094 C/T cg02927042 chr1:21476669 EIF4G3 -0.48 -7.58 -0.39 3.67e-13 Superior frontal gyrus grey matter volume; CRC cis rs2745967 0.740 rs2796253 chr1:208067409 G/A cg09788693 chr1:208063733 CD34 0.47 7.04 0.36 1.13e-11 Resting heart rate; CRC cis rs4665809 0.590 rs7588328 chr2:26469788 G/A cg04944784 chr2:26401820 FAM59B 0.85 11.05 0.52 2.29e-24 Gut microbiome composition (summer); CRC cis rs3820068 0.532 rs6701009 chr1:15935614 T/C cg13390004 chr1:15929781 NA 0.5 7.09 0.36 8.03e-12 Systolic blood pressure; CRC cis rs4242434 0.857 rs11777808 chr8:22462755 A/C cg03733263 chr8:22462867 KIAA1967 1.04 20.11 0.74 3.29e-59 Exploratory eye movement dysfunction in schizophrenia (cognitive search score); CRC cis rs9389248 0.500 rs116273677 chr6:135339135 A/C cg24558204 chr6:135376177 HBS1L 0.51 7.93 0.4 3.41e-14 High light scatter reticulocyte percentage of red cells; CRC cis rs116095464 0.558 rs7708182 chr5:234788 C/G cg22496380 chr5:211416 CCDC127 -0.91 -10.38 -0.5 5.2e-22 Breast cancer; CRC trans rs11098499 0.743 rs11098501 chr4:120252017 T/G cg25214090 chr10:38739885 LOC399744 0.53 8.36 0.42 1.81e-15 Corneal astigmatism; CRC trans rs7618501 1.000 rs35261599 chr3:49773236 G/A cg21659725 chr3:3221576 CRBN -0.91 -17.8 -0.7 4.19e-50 Intelligence (multi-trait analysis); CRC cis rs2658782 0.789 rs3020076 chr11:93141058 C/T cg15737290 chr11:93063684 CCDC67 0.47 6.75 0.35 6.7e-11 Pulmonary function decline; CRC trans rs2235573 0.551 rs139898 chr22:38399979 A/G cg19894588 chr14:64061835 NA 0.51 7.47 0.38 7.13e-13 Glioblastoma;Glioma; CRC cis rs597539 0.652 rs516425 chr11:68715675 G/A cg04772025 chr11:68637568 NA 0.46 7.11 0.36 7.44e-12 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs734999 0.505 rs4073286 chr1:2539901 A/C cg18854424 chr1:2615690 NA 0.49 9.9 0.48 2.09e-20 Ulcerative colitis; CRC trans rs587242 1.000 rs10489740 chr1:96919182 G/A cg10631902 chr5:14652156 NA 0.45 7.05 0.36 1.08e-11 Body mass index (joint analysis main effects and physical activity interaction);Body mass index in physically inactive individuals;Body mass index; CRC cis rs2576037 0.526 rs4890699 chr18:44541029 T/C cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.53 8.43 0.42 1.06e-15 Personality dimensions; CRC cis rs172166 0.516 rs2622322 chr6:28117443 C/G cg10876282 chr6:28092338 ZSCAN16 0.4 5.71 0.3 2.52e-8 Cardiac Troponin-T levels; CRC cis rs9487051 0.714 rs1546722 chr6:109625797 A/G cg21918786 chr6:109611834 NA -0.4 -7.11 -0.36 7.47e-12 Reticulocyte fraction of red cells; CRC cis rs270601 0.909 rs2569265 chr5:131704519 T/C cg18301423 chr5:131593218 PDLIM4 -0.38 -6.27 -0.33 1.11e-9 Acylcarnitine levels; CRC cis rs7107174 1.000 rs2511175 chr11:77975081 A/G cg02023728 chr11:77925099 USP35 0.5 7.23 0.37 3.39e-12 Testicular germ cell tumor; CRC cis rs10540 1.000 rs12421457 chr11:505780 T/C cg08200582 chr11:442649 ANO9 -0.71 -7.44 -0.38 8.72e-13 Body mass index; CRC cis rs4268898 0.552 rs11125444 chr2:24367205 G/T cg06627628 chr2:24431161 ITSN2 0.45 6.86 0.35 3.47e-11 Asthma; CRC cis rs9388451 0.807 rs1268065 chr6:126042783 G/A cg05901451 chr6:126070800 HEY2 0.64 10.63 0.51 6.77e-23 Brugada syndrome; CRC cis rs7772486 0.654 rs1011597 chr6:146075672 A/C cg23711669 chr6:146136114 FBXO30 -0.66 -10.97 -0.52 4.56e-24 Lobe attachment (rater-scored or self-reported); CRC cis rs7727544 0.669 rs113823725 chr5:131563501 C/G cg04518342 chr5:131593106 PDLIM4 0.37 6.65 0.34 1.25e-10 Blood metabolite levels; CRC cis rs9905704 0.918 rs302862 chr17:56697444 G/T cg12560992 chr17:57184187 TRIM37 0.56 7.63 0.39 2.62e-13 Testicular germ cell tumor; CRC cis rs1344694 0.566 rs13029765 chr2:216894976 A/T cg12620499 chr2:216877984 MREG 0.77 12.32 0.56 6.39e-29 Alcohol dependence; CRC cis rs2243480 0.803 rs34804747 chr7:65412942 G/C cg18252515 chr7:66147081 NA -1.06 -12.44 -0.57 2.13e-29 Diabetic kidney disease; CRC cis rs2731664 0.792 rs2544809 chr5:176885499 T/C cg23176889 chr5:176863531 GRK6 -0.73 -16.09 -0.66 2.27e-43 Intelligence (multi-trait analysis); CRC trans rs1728785 1.000 rs1749792 chr16:68569440 T/G cg04657470 chr2:198365150 HSPE1;HSPD1 0.58 6.97 0.36 1.72e-11 Ulcerative colitis; CRC cis rs12760731 0.582 rs6658398 chr1:178558881 T/C cg00404053 chr1:178313656 RASAL2 0.67 7.37 0.38 1.43e-12 Obesity-related traits; CRC cis rs796364 0.951 rs10931888 chr2:201022952 T/G cg25936922 chr2:200820526 C2orf60;C2orf47 -0.72 -7.52 -0.38 5.13e-13 Schizophrenia; CRC cis rs7552404 0.855 rs385897 chr1:76106962 T/C cg03433033 chr1:76189801 ACADM -0.81 -11.14 -0.52 1.12e-24 Blood metabolite levels;Acylcarnitine levels; CRC cis rs4819052 1.000 rs13047688 chr21:46669290 G/A cg19498844 chr21:46707878 POFUT2;LOC642852 0.8 10.71 0.51 3.6e-23 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs1448094 0.512 rs11832992 chr12:86240790 T/C cg18827107 chr12:86230957 RASSF9 -0.46 -7.54 -0.38 4.63e-13 Major depressive disorder; CRC cis rs7131987 0.903 rs11050163 chr12:29420398 C/T cg09582351 chr12:29534625 ERGIC2 -0.29 -6.17 -0.32 1.97e-9 QT interval; CRC cis rs6681460 0.625 rs12138066 chr1:67103816 C/T cg02459107 chr1:67143332 SGIP1 0.32 5.81 0.31 1.48e-8 Presence of antiphospholipid antibodies; CRC cis rs34375054 0.752 rs12582808 chr12:125661459 G/T cg05341575 chr12:125625032 AACS -0.4 -5.62 -0.3 4.03e-8 Post bronchodilator FEV1/FVC ratio; CRC cis rs2836974 0.799 rs13047550 chr21:40515495 T/C cg11644478 chr21:40555479 PSMG1 0.71 10.19 0.49 2.19e-21 Cognitive function; CRC trans rs6703335 0.870 rs10803142 chr1:243598234 A/G cg17942371 chr19:796826 PTBP1 0.43 6.3 0.33 9.57e-10 Schizophrenia;Schizophrenia, schizoaffective disorder or bipolar disorder; CRC cis rs2228479 0.850 rs11647174 chr16:89958538 G/A cg19635926 chr16:89946313 TCF25 0.65 6.21 0.32 1.55e-9 Skin colour saturation; CRC cis rs10782582 0.545 rs12138018 chr1:76186794 T/C cg10523679 chr1:76189770 ACADM -0.41 -5.89 -0.31 9.51e-9 Daytime sleep phenotypes; CRC cis rs9487051 0.768 rs351742 chr6:109527325 C/T cg01475377 chr6:109611718 NA 0.35 6.11 0.32 2.79e-9 Reticulocyte fraction of red cells; CRC cis rs12497850 0.865 rs7649458 chr3:48920127 C/T cg07636037 chr3:49044803 WDR6 1.02 18.52 0.71 5.84e-53 Parkinson's disease; CRC cis rs6951245 0.554 rs75075857 chr7:1140298 C/T cg18402987 chr7:1209562 NA 0.52 6.27 0.33 1.1e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs1881396 0.945 rs1881395 chr2:27838549 G/A cg27432699 chr2:27873401 GPN1 0.61 7.93 0.4 3.5e-14 Nonalcoholic fatty liver disease; CRC cis rs9916302 0.904 rs11654018 chr17:37703740 C/T cg15445000 chr17:37608096 MED1 -0.42 -9.34 -0.46 1.47e-18 Glomerular filtration rate (creatinine); CRC cis rs6840360 1.000 rs6535809 chr4:152592933 A/G cg09659197 chr4:152720779 NA 0.52 11.26 0.53 4.18e-25 Intelligence (multi-trait analysis); CRC trans rs6703335 0.870 rs10803142 chr1:243598234 A/G cg16708785 chr19:38085709 ZNF540;ZNF571 0.4 6.01 0.31 5.02e-9 Schizophrenia;Schizophrenia, schizoaffective disorder or bipolar disorder; CRC cis rs910187 0.605 rs3787239 chr20:45802729 T/C cg27589058 chr20:45804311 EYA2 -0.42 -8.04 -0.41 1.6e-14 Migraine; CRC trans rs1493916 0.777 rs1493910 chr18:31318376 A/G cg27147174 chr7:100797783 AP1S1 -0.39 -6.64 -0.34 1.3100000000000001e-10 Life satisfaction; CRC cis rs262150 1.000 rs262154 chr7:158773936 G/A cg10570241 chr7:158785291 NA 0.46 7.59 0.39 3.3e-13 Facial morphology (factor 20); CRC cis rs711830 0.587 rs10188827 chr2:177007664 C/T cg13092806 chr2:177043255 NA 0.54 6.18 0.32 1.88e-9 Serous invasive ovarian cancer;Epithelial ovarian cancer;Invasive epithelial ovarian cancer;Mucinous ovarian carcinoma;Low-grade serous and serous borderline ovarian cancer;Serous borderline ovarian cancer;High-grade serous ovarian cancer; CRC cis rs8180040 0.620 rs11709660 chr3:47074927 G/A cg27129171 chr3:47204927 SETD2 -0.73 -11.53 -0.54 4.47e-26 Colorectal cancer; CRC trans rs7618501 1.000 rs7372725 chr3:49790544 C/A cg21659725 chr3:3221576 CRBN -0.91 -17.2 -0.69 9.93e-48 Intelligence (multi-trait analysis); CRC cis rs10883723 0.810 rs7094751 chr10:104274818 G/A cg04362960 chr10:104952993 NT5C2 -0.42 -5.94 -0.31 7.28e-9 Allergic disease (asthma, hay fever or eczema); CRC cis rs7552404 0.961 rs211710 chr1:76109038 G/A cg22875332 chr1:76189707 ACADM -0.67 -8.93 -0.44 3.1e-17 Blood metabolite levels;Acylcarnitine levels; CRC cis rs3790844 0.667 rs3790843 chr1:200010824 A/G cg13229857 chr1:200006247 NR5A2 -0.51 -7.46 -0.38 7.65e-13 Pancreatic cancer; CRC cis rs12477438 0.501 rs2632260 chr2:99771590 G/T cg26064155 chr2:99771622 LIPT1;TSGA10 0.9 16.75 0.68 5.43e-46 Chronic sinus infection; CRC cis rs2249625 0.523 rs2463707 chr6:72861732 G/A cg18830697 chr6:72922368 RIMS1 -0.31 -6.19 -0.32 1.8e-9 Acute urticaria and angioedema (non-steroidal anti-inflammatory drug-induced); CRC cis rs904251 0.861 rs1757173 chr6:37486952 A/C cg25019722 chr6:37503610 NA -0.5 -9.29 -0.46 2.17e-18 Cognitive performance; CRC trans rs61931739 0.517 rs10844830 chr12:34308133 C/T cg26384229 chr12:38710491 ALG10B 0.44 6.43 0.33 4.45e-10 Morning vs. evening chronotype; CRC trans rs2303319 0.504 rs62189055 chr2:162625749 C/A cg14225146 chr17:72744664 SLC9A3R1 -0.68 -6.08 -0.32 3.32e-9 Cognitive function; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg21687924 chr11:3400496 ZNF195 0.47 6.21 0.32 1.57e-9 Anxiety disorder; CRC cis rs3806843 1.000 rs2240694 chr5:140183058 G/A cg19875535 chr5:140030758 IK 0.6 9.85 0.48 3.25e-20 Depressive symptoms (multi-trait analysis); CRC cis rs367615 0.704 rs7726991 chr5:108847434 C/T cg17395555 chr5:108820864 NA 0.46 9.36 0.46 1.25e-18 Colorectal cancer (SNP x SNP interaction); CRC cis rs7809950 0.678 rs2107317 chr7:106899685 T/C cg23024343 chr7:107201750 COG5 -0.75 -10.4 -0.5 4.37e-22 Coronary artery disease; CRC cis rs4243830 0.522 rs10864614 chr1:6596008 G/A cg05709478 chr1:6581295 PLEKHG5 -0.58 -6.93 -0.36 2.25e-11 Body mass index; CRC cis rs6089584 0.888 rs6061405 chr20:60617033 A/G cg23463467 chr20:60627584 TAF4 0.32 5.66 0.3 3.25e-8 Body mass index; CRC cis rs870825 0.616 rs4623060 chr4:185642943 A/G cg04058563 chr4:185651563 MLF1IP 0.73 9.54 0.47 3.27e-19 Blood protein levels; CRC trans rs116095464 0.558 rs10057299 chr5:242135 C/T cg00938859 chr5:1591904 SDHAP3 0.72 7.76 0.39 1.09e-13 Breast cancer; CRC cis rs4713118 0.662 rs175954 chr6:28011585 A/G cg06470822 chr6:28175283 NA 0.9 13.27 0.59 1.68e-32 Parkinson's disease; CRC cis rs2841277 0.708 rs28600075 chr14:105408315 T/C cg15352829 chr14:105391018 PLD4 -0.49 -10.75 -0.51 2.71e-23 Rheumatoid arthritis; CRC trans rs11722228 0.522 rs1109472 chr4:10134448 C/G cg26043149 chr18:55253948 FECH 1.04 16.34 0.67 2.3e-44 Gout;Urate levels;Serum uric acid levels; CRC cis rs9868809 0.881 rs2310996 chr3:48671834 T/C cg07636037 chr3:49044803 WDR6 -0.63 -6.74 -0.35 7.05e-11 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; CRC cis rs11190604 1.000 rs4919464 chr10:102221195 A/G cg16342193 chr10:102329863 NA -0.37 -6.1 -0.32 2.96e-9 Palmitoleic acid (16:1n-7) levels; CRC cis rs881375 0.967 rs7848332 chr9:123669496 T/C cg09419670 chr9:123605666 PSMD5;LOC253039 0.6 8.81 0.44 7.32e-17 Rheumatoid arthritis; CRC cis rs9487051 0.676 rs4383852 chr6:109594475 G/A cg21918786 chr6:109611834 NA -0.42 -7.36 -0.38 1.47e-12 Reticulocyte fraction of red cells; CRC cis rs7959452 0.640 rs1598543 chr12:69688757 G/T cg20891283 chr12:69753455 YEATS4 0.8 13.3 0.59 1.38e-32 Blood protein levels; CRC cis rs514406 0.760 rs475969 chr1:53292607 T/A cg24675658 chr1:53192096 ZYG11B -0.73 -11.4 -0.53 1.33e-25 Monocyte count; CRC trans rs7618501 1.000 rs6802890 chr3:49832261 A/G cg21582582 chr3:182698605 DCUN1D1 0.53 7.93 0.4 3.45e-14 Intelligence (multi-trait analysis); CRC cis rs6502050 0.835 rs3935128 chr17:80113414 T/C cg11859384 chr17:80120422 CCDC57 -0.37 -5.85 -0.31 1.16e-8 Life satisfaction; CRC cis rs6908034 0.556 rs77486465 chr6:19803862 T/G cg02682789 chr6:19804855 NA 0.81 6.89 0.35 2.9100000000000002e-11 Endometriosis;Deep ovarian and/or rectovaginal disease with dense adhesions; CRC cis rs992157 0.798 rs4996257 chr2:219162836 C/T cg13835894 chr2:219148914 PNKD;TMBIM1 0.31 5.92 0.31 8.06e-9 Colorectal cancer; CRC cis rs4819052 1.000 rs733738 chr21:46666396 A/G cg02159808 chr21:46707872 POFUT2;LOC642852 -0.63 -7.6 -0.39 3.19e-13 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs1153858 1.000 rs16942568 chr15:45677390 T/C cg21132104 chr15:45694354 SPATA5L1 0.59 8.51 0.42 6.4e-16 Homoarginine levels; CRC cis rs11083475 0.599 rs7250443 chr19:39267345 T/C cg26703956 chr19:39260304 NA -0.38 -5.93 -0.31 7.85e-9 Heart rate; CRC cis rs113835537 0.935 rs79496339 chr11:66467769 T/A cg22134325 chr11:66188745 NPAS4 0.36 5.85 0.31 1.18e-8 Airway imaging phenotypes; CRC cis rs11628318 0.853 rs8003309 chr14:103050143 C/G cg23461800 chr14:103021989 NA -0.76 -9.99 -0.48 1.08e-20 Platelet count; CRC cis rs2067615 0.579 rs7964605 chr12:107205413 C/T cg13491945 chr12:107078410 RFX4 -0.36 -6.14 -0.32 2.36e-9 Heart rate; CRC cis rs6445525 0.870 rs2060023 chr3:65999532 C/T cg06109867 chr3:66002991 MAGI1 0.37 6.09 0.32 3.07e-9 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs7772486 0.754 rs702304 chr6:145990797 A/G cg05347473 chr6:146136440 FBXO30 -0.4 -6.08 -0.32 3.32e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs11098499 0.754 rs938056 chr4:120237453 C/T cg24375607 chr4:120327624 NA 0.47 7.58 0.39 3.55e-13 Corneal astigmatism; CRC cis rs2463822 0.925 rs17157227 chr11:62169772 A/G cg06239285 chr11:62104954 ASRGL1 0.87 9.03 0.45 1.5e-17 Chronic obstructive pulmonary disease-related biomarkers; CRC trans rs208520 0.955 rs208538 chr6:66964492 C/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.88 -10.95 -0.52 5.22e-24 Exhaled nitric oxide output; CRC cis rs4332037 0.707 rs56070303 chr7:1891015 C/T cg21155852 chr7:2048760 MAD1L1 -0.42 -6.07 -0.32 3.56e-9 Bipolar disorder; CRC trans rs12599106 0.560 rs34151874 chr16:34989694 G/A cg07332563 chr6:291687 DUSP22 -0.59 -8.54 -0.43 5.04e-16 Menopause (age at onset); CRC cis rs6951245 0.872 rs76713558 chr7:1095866 A/G cg07217954 chr7:1067459 C7orf50 0.55 5.72 0.3 2.36e-8 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs736408 0.609 rs13082208 chr3:52781539 T/G cg15147215 chr3:52552868 STAB1 -0.61 -9.94 -0.48 1.54e-20 Bipolar disorder; CRC cis rs6952808 0.964 rs10950400 chr7:1882470 C/T cg02951883 chr7:2050386 MAD1L1 -0.72 -11.18 -0.52 8.34e-25 Bipolar disorder and schizophrenia; CRC cis rs1005277 0.563 rs2800550 chr10:38482929 T/C cg17219203 chr10:38645113 HSD17B7P2 -0.4 -5.61 -0.3 4.37e-8 Extrinsic epigenetic age acceleration; CRC trans rs561341 1.000 rs4795667 chr17:30244443 T/C cg20587970 chr11:113659929 NA -1.32 -18.32 -0.71 3.62e-52 Hip circumference adjusted for BMI; CRC cis rs6662572 0.737 rs7533750 chr1:46558434 G/C cg08644498 chr1:46502608 NA 0.45 7.18 0.37 4.64e-12 Blood protein levels; CRC cis rs7172677 0.768 rs12148425 chr15:75354972 T/C cg14664628 chr15:75095509 CSK 0.54 6.47 0.34 3.53e-10 Systemic lupus erythematosus and Systemic sclerosis; CRC cis rs2243480 1.000 rs781149 chr7:65481284 C/T cg25985355 chr7:65971099 NA -0.5 -5.73 -0.3 2.25e-8 Diabetic kidney disease; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg13388111 chr11:61062665 VWCE 0.34 6.34 0.33 7.39e-10 Liver disease severity in Alagille syndrome; CRC cis rs11148252 0.904 rs9568732 chr13:52993412 A/G cg12458913 chr13:53173898 NA -0.58 -9.27 -0.46 2.55e-18 Lewy body disease; CRC cis rs9322193 0.884 rs7450246 chr6:150023653 C/T cg13206674 chr6:150067644 NUP43 0.66 10.02 0.48 8.65e-21 Lung cancer; CRC cis rs514406 0.679 rs545719 chr1:53304922 T/C cg27535305 chr1:53392650 SCP2 -0.44 -7.94 -0.4 3.21e-14 Monocyte count; CRC cis rs11148252 0.532 rs9536190 chr13:53181044 T/C cg00495681 chr13:53174319 NA 1.1 22.48 0.78 1.83e-68 Lewy body disease; CRC cis rs910316 1.000 rs10149880 chr14:75633008 A/G cg03030879 chr14:75389066 RPS6KL1 0.47 7.21 0.37 3.91e-12 Height; CRC cis rs4332037 0.539 rs56016347 chr7:2060126 C/T cg13880726 chr7:1868755 MAD1L1 -0.47 -5.78 -0.3 1.75e-8 Bipolar disorder; CRC cis rs17023223 0.537 rs7525871 chr1:119621894 T/C cg05756136 chr1:119680316 WARS2 -0.53 -7.13 -0.37 6.6e-12 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for BMI in active individuals; CRC cis rs863345 0.604 rs11264981 chr1:158455890 C/T cg12129480 chr1:158549410 OR10X1 -0.29 -6.05 -0.32 3.87e-9 Pneumococcal bacteremia; CRC cis rs1552244 0.572 rs58223482 chr3:10169746 G/C cg00166722 chr3:10149974 C3orf24 0.66 7.71 0.39 1.49e-13 Alzheimer's disease; CRC cis rs929354 0.713 rs7798816 chr7:156940574 A/G cg05182265 chr7:156933206 UBE3C -0.76 -14.38 -0.62 1.04e-36 Body mass index; CRC cis rs9467711 0.651 rs2051539 chr6:25947259 G/C cg08501292 chr6:25962987 TRIM38 1.1 10.5 0.5 1.9e-22 Autism spectrum disorder or schizophrenia; CRC cis rs807029 0.577 rs7902510 chr10:102757934 C/T cg04662943 chr10:102668895 NA 0.61 7.13 0.37 6.44e-12 Ejection fraction in Tripanosoma cruzi seropositivity; CRC cis rs2658782 0.724 rs2658770 chr11:93261886 A/G cg15737290 chr11:93063684 CCDC67 0.57 7.84 0.4 6.49e-14 Pulmonary function decline; CRC cis rs853679 0.517 rs1904841 chr6:28108085 C/T cg25164649 chr6:28176230 NA 0.77 9.54 0.47 3.29e-19 Depression; CRC cis rs8058578 1.000 rs8051050 chr16:30687909 A/G cg02466173 chr16:30829666 NA -0.8 -12.6 -0.57 5.5e-30 Multiple myeloma; CRC cis rs6502050 0.805 rs9898326 chr17:80119582 C/T cg19223190 chr17:80058835 NA 0.39 6.23 0.32 1.43e-9 Life satisfaction; CRC cis rs7769051 1.000 rs9399041 chr6:133096233 T/G cg22852734 chr6:133119734 C6orf192 0.93 11.01 0.52 3.31e-24 Type 2 diabetes nephropathy; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg02467765 chr4:78978708 FRAS1 0.41 6.18 0.32 1.91e-9 Response to antipsychotic treatment; CRC cis rs2274273 0.686 rs66531545 chr14:55587460 T/C cg10130446 chr14:55658398 DLGAP5 -0.42 -5.72 -0.3 2.33e-8 Protein biomarker; CRC cis rs1862618 0.671 rs2591956 chr5:56244604 G/A cg12311346 chr5:56204834 C5orf35 0.64 9.66 0.47 1.3e-19 Initial pursuit acceleration; CRC cis rs2836974 0.899 rs34433511 chr21:40618883 A/C cg17971929 chr21:40555470 PSMG1 0.83 11.96 0.55 1.32e-27 Cognitive function; CRC cis rs10504229 0.775 rs72650869 chr8:58157923 T/A cg21724239 chr8:58056113 NA 0.64 8.48 0.42 8e-16 Developmental language disorder (linguistic errors); CRC cis rs908922 0.676 rs4112785 chr1:152533115 G/C cg23254163 chr1:152506842 NA 0.49 9.71 0.47 8.86e-20 Hair morphology; CRC cis rs1639906 0.560 rs1624785 chr7:2258139 T/C cg19897017 chr7:2163380 MAD1L1 0.41 5.93 0.31 7.57e-9 Colonoscopy-negative controls vs population controls; CRC cis rs11676348 0.755 rs13410318 chr2:219022910 T/G cg00012203 chr2:219082015 ARPC2 0.44 6.77 0.35 6.07e-11 Ulcerative colitis; CRC cis rs1129187 0.791 rs1129186 chr6:42932202 C/T cg02359409 chr6:42947317 PEX6 -0.68 -11.36 -0.53 1.83e-25 Alzheimer's disease in APOE e4+ carriers; CRC cis rs7586879 0.828 rs4077677 chr2:25122798 G/C cg22495460 chr2:25135724 ADCY3 -0.87 -14.86 -0.63 1.37e-38 Body mass index; CRC cis rs6860806 0.507 rs2631369 chr5:131705266 G/C cg22638593 chr5:131593259 PDLIM4 -0.41 -6.92 -0.36 2.44e-11 Breast cancer; CRC cis rs2898857 0.504 rs7214496 chr17:47384611 C/G cg08112188 chr17:47440006 ZNF652 0.42 5.61 0.3 4.21e-8 Cancer; CRC cis rs10392 0.543 rs3752292 chr20:37570475 G/A cg27552599 chr20:37590471 DHX35 0.37 5.72 0.3 2.45e-8 Alcohol dependence or chronic alcoholic pancreatitis or alcohol-related liver cirrhosis; CRC cis rs4604732 0.631 rs1106721 chr1:247624676 A/C cg02104434 chr1:247694406 LOC148824;OR2C3 0.6 8.92 0.44 3.24e-17 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CRC cis rs514406 0.861 rs1412706 chr1:53237721 G/A cg25767906 chr1:53392781 SCP2 0.45 7.23 0.37 3.5e-12 Monocyte count; CRC cis rs12024301 0.557 rs10911410 chr1:183661361 G/A cg11505048 chr1:183622726 RGL1;APOBEC4 0.71 6.24 0.33 1.33e-9 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs1865760 0.532 rs1061482 chr6:26086699 G/T cg16482183 chr6:26056742 HIST1H1C 0.52 7.62 0.39 2.74e-13 Height; CRC cis rs7312933 0.670 rs2406568 chr12:42552297 G/C cg11827402 chr12:42719852 PPHLN1;ZCRB1 0.63 8.8 0.44 8.09e-17 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CRC cis rs6694672 1.000 rs857020 chr1:197017473 C/T cg13682187 chr1:196946512 CFHR5 0.43 6.92 0.36 2.35e-11 Asthma; CRC cis rs6964587 1.000 rs7805077 chr7:91644553 A/G cg17063962 chr7:91808500 NA 0.8 14.22 0.62 4.36e-36 Breast cancer; CRC cis rs477692 1.000 rs513736 chr10:131406489 C/T cg05714579 chr10:131428358 MGMT 0.56 8.21 0.41 5.14e-15 Response to temozolomide; CRC cis rs877282 0.891 rs11253406 chr10:796297 G/A cg06581033 chr10:766294 NA -0.51 -5.68 -0.3 2.97e-8 Uric acid levels; CRC cis rs7772486 0.790 rs1062067 chr6:146207563 A/G cg13319975 chr6:146136371 FBXO30 -0.4 -6.14 -0.32 2.32e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs79387448 0.745 rs1523197 chr2:103163732 A/G cg09003973 chr2:102972529 NA 0.73 8.01 0.4 1.97e-14 Gut microbiota (bacterial taxa); CRC cis rs78456975 0.546 rs72776254 chr2:1527881 C/T cg12573674 chr2:1569213 NA -0.73 -7.39 -0.38 1.23e-12 Placebo response in major depressive disorder (% change in symptom score); CRC cis rs2985684 0.748 rs2985686 chr14:50100683 C/G cg10008539 chr14:50087325 RPL36AL;MGAT2 -0.47 -6.44 -0.33 4.14e-10 Carotid intima media thickness; CRC cis rs10504229 0.517 rs75486476 chr8:58056079 G/T cg08219700 chr8:58056026 NA 0.68 11.92 0.55 1.83e-27 Developmental language disorder (linguistic errors); CRC cis rs6752107 1.000 rs2241880 chr2:234183368 A/G cg07618928 chr2:234183455 ATG16L1;SCARNA5 0.67 11.65 0.54 1.77e-26 Crohn's disease;Inflammatory bowel disease; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg23079732 chr1:26232465 STMN1 0.39 6.05 0.32 3.95e-9 Liver disease severity in Alagille syndrome; CRC cis rs7843479 0.601 rs10101881 chr8:21830158 A/G cg17168535 chr8:21777572 XPO7 0.56 8.9 0.44 3.88e-17 Mean corpuscular volume; CRC cis rs7666738 0.680 rs11726233 chr4:99079773 G/A cg17366294 chr4:99064904 C4orf37 0.39 6.45 0.34 3.91e-10 Colonoscopy-negative controls vs population controls; CRC cis rs10504229 0.953 rs75545548 chr8:58172816 T/C cg22535103 chr8:58192502 C8orf71 -0.82 -12.27 -0.56 9.63e-29 Developmental language disorder (linguistic errors); CRC cis rs7727544 0.735 rs2631370 chr5:131703776 T/C cg11843238 chr5:131593191 PDLIM4 -0.32 -5.93 -0.31 7.63e-9 Blood metabolite levels; CRC cis rs1005277 0.579 rs1780136 chr10:38501453 A/G cg25517755 chr10:38738941 LOC399744 -0.4 -5.91 -0.31 8.75e-9 Extrinsic epigenetic age acceleration; CRC cis rs172166 0.637 rs1225597 chr6:28162087 C/T cg15786705 chr6:28176104 NA 0.68 10.33 0.49 7.66e-22 Cardiac Troponin-T levels; CRC cis rs1451375 0.756 rs11761683 chr7:50542879 C/T cg14593290 chr7:50529359 DDC -0.54 -7.36 -0.38 1.44e-12 Malaria; CRC cis rs9926296 0.533 rs9938865 chr16:89867797 A/G cg21285383 chr16:89894308 SPIRE2 0.38 6.56 0.34 2.09e-10 Vitiligo; CRC cis rs6951245 1.000 rs113858334 chr7:1073476 A/G cg21664854 chr7:1097933 C7orf50;GPR146 0.79 8.92 0.44 3.39e-17 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs863345 0.604 rs1342948 chr1:158463294 A/G cg12129480 chr1:158549410 OR10X1 -0.3 -6.16 -0.32 2.16e-9 Pneumococcal bacteremia; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg03952484 chr1:149899818 SF3B4 0.48 6.17 0.32 2.03e-9 Thyroid stimulating hormone; CRC cis rs651907 0.557 rs56291106 chr3:101377474 C/T cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.62 8.41 0.42 1.3e-15 Colorectal cancer; CRC cis rs523522 0.962 rs10849758 chr12:120971149 C/T cg12219531 chr12:120966889 COQ5 0.69 9.28 0.46 2.36e-18 High light scatter reticulocyte count; CRC cis rs780096 0.526 rs7594812 chr2:27611469 A/G cg02592271 chr2:27665507 KRTCAP3 -0.26 -5.97 -0.31 6e-9 Total body bone mineral density; CRC cis rs2013441 1.000 rs17686839 chr17:20039171 A/G cg13482628 chr17:19912719 NA 0.41 6.33 0.33 7.87e-10 Obesity-related traits; CRC cis rs7208859 0.562 rs11650923 chr17:29008167 G/A cg01831904 chr17:28903510 LRRC37B2 -0.64 -6.31 -0.33 9.22e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg25522149 chr19:11372842 DOCK6 0.38 6.02 0.31 4.76e-9 Intelligence (multi-trait analysis); CRC cis rs853679 0.760 rs9393910 chr6:28208192 C/G cg06470822 chr6:28175283 NA 0.76 8.05 0.41 1.49e-14 Depression; CRC cis rs11997175 0.587 rs72612118 chr8:33695225 T/C ch.8.33884649F chr8:33765107 NA 0.46 6.67 0.35 1.05e-10 Body mass index; CRC cis rs17253792 0.545 rs12894368 chr14:56025178 C/A cg01858014 chr14:56050164 KTN1 -0.84 -6.52 -0.34 2.6200000000000003e-10 Putamen volume; CRC cis rs13191362 1.000 rs73035023 chr6:163000927 C/T cg06582575 chr6:163149167 PACRG;PARK2 0.79 10.88 0.51 9.36e-24 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs7666738 0.822 rs17484018 chr4:98988960 G/A cg17366294 chr4:99064904 C4orf37 0.44 7.39 0.38 1.23e-12 Colonoscopy-negative controls vs population controls; CRC cis rs10504229 0.636 rs77290284 chr8:58055269 G/T cg20607798 chr8:58055168 NA 0.52 5.94 0.31 7.24e-9 Developmental language disorder (linguistic errors); CRC cis rs1448094 0.836 rs7313442 chr12:86405642 C/T cg02569458 chr12:86230093 RASSF9 0.4 6.75 0.35 6.7e-11 Major depressive disorder; CRC cis rs7953508 0.506 rs12425869 chr12:93961353 A/G cg18151635 chr12:93972918 NA -0.71 -10.38 -0.5 5.02e-22 Pubertal anthropometrics; CRC cis rs41271473 0.500 rs4440831 chr1:228887522 C/T cg00850481 chr1:228891306 NA 0.45 7.04 0.36 1.12e-11 Chronic lymphocytic leukemia; CRC cis rs13108904 0.870 rs4493483 chr4:1279916 G/A cg19318889 chr4:1322082 MAEA 0.4 5.68 0.3 2.94e-8 Obesity-related traits; CRC cis rs9322193 0.923 rs9479810 chr6:150072495 C/T cg13206674 chr6:150067644 NUP43 0.56 8.13 0.41 8.97e-15 Lung cancer; CRC cis rs12477438 0.765 rs10181344 chr2:99692829 C/T cg26064155 chr2:99771622 LIPT1;TSGA10 -0.63 -8.55 -0.43 4.61e-16 Chronic sinus infection; CRC cis rs17253792 0.822 rs13379340 chr14:56050346 C/G cg24579896 chr14:56047964 C14orf33;KTN1 0.68 5.79 0.3 1.68e-8 Putamen volume; CRC cis rs9354352 1.000 rs9354352 chr6:66696272 T/C cg07460842 chr6:66804631 NA 0.62 9.07 0.45 1.07e-17 Initial pursuit acceleration in psychotic disorders; CRC cis rs6582630 0.502 rs11610978 chr12:38356957 C/G cg26384229 chr12:38710491 ALG10B 0.67 9.79 0.47 5.15e-20 Drug-induced liver injury (flucloxacillin); CRC cis rs2976388 0.578 rs3758081 chr8:143824373 A/G cg04969067 chr8:143858791 LYNX1 -0.42 -6.33 -0.33 8.17e-10 Urinary tract infection frequency; CRC cis rs2806561 0.734 rs2235548 chr1:23394062 G/A cg12483005 chr1:23474871 LUZP1 0.46 6.48 0.34 3.36e-10 Height; CRC cis rs5769707 0.904 rs7288869 chr22:50015327 C/T cg10356904 chr22:49881777 NA -0.34 -6.53 -0.34 2.56e-10 Monocyte count;Monocyte percentage of white cells; CRC cis rs12476592 0.602 rs262482 chr2:63877042 C/T cg10828910 chr2:63850056 LOC388955 0.5 6.16 0.32 2.1e-9 Childhood ear infection; CRC cis rs2949837 0.581 rs2960434 chr7:45972977 A/G cg23193639 chr7:45961078 IGFBP3 0.38 6.38 0.33 6.18e-10 Sitting height ratio; CRC cis rs853679 0.517 rs9393887 chr6:28059020 G/A cg23161317 chr6:28129485 ZNF389 0.52 6.42 0.33 4.83e-10 Depression; CRC cis rs651907 0.557 rs13099674 chr3:101489629 G/A cg12386194 chr3:101231763 SENP7 0.47 6.9 0.36 2.64e-11 Colorectal cancer; CRC cis rs7246657 0.941 rs12982333 chr19:37794724 A/G cg23950597 chr19:37808831 NA -0.51 -6.11 -0.32 2.86e-9 Coronary artery calcification; CRC cis rs72945132 0.882 rs55738915 chr11:70190019 C/T cg00319359 chr11:70116639 PPFIA1 0.65 6.88 0.35 3.11e-11 Coronary artery disease; CRC cis rs7615952 0.515 rs7637246 chr3:125678706 A/G cg05084668 chr3:125655381 ALG1L -0.68 -10.24 -0.49 1.5e-21 Blood pressure (smoking interaction); CRC cis rs6921919 0.583 rs9468370 chr6:28368940 C/T cg21251018 chr6:28226885 NKAPL 0.37 5.6 0.3 4.48e-8 Autism spectrum disorder or schizophrenia; CRC cis rs6743376 0.556 rs12475161 chr2:113823626 T/C cg24553058 chr2:113831203 IL1F10 0.43 7.09 0.36 8.4e-12 Inflammatory biomarkers; CRC cis rs9443645 0.901 rs9359354 chr6:79590385 A/G cg11833968 chr6:79620685 NA -0.37 -6.48 -0.34 3.34e-10 Intelligence (multi-trait analysis); CRC trans rs12478296 1.000 rs55742408 chr2:243041077 G/A cg06834434 chr14:75079333 LTBP2 0.55 6.5 0.34 2.92e-10 Obesity-related traits; CRC cis rs6951245 0.554 rs76243429 chr7:1152543 C/T cg18402987 chr7:1209562 NA 0.57 7.0 0.36 1.48e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs12497850 0.897 rs9884022 chr3:48956862 G/C cg20833759 chr3:49053208 WDR6;DALRD3 0.53 9.23 0.45 3.46e-18 Parkinson's disease; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg06104511 chr16:46655473 SHCBP1 0.43 6.18 0.32 1.94e-9 Intelligence (multi-trait analysis); CRC cis rs8058578 1.000 rs13338946 chr16:30700858 T/C cg00531865 chr16:30841666 NA -0.43 -5.82 -0.31 1.41e-8 Multiple myeloma; CRC trans rs11098499 0.754 rs1849457 chr4:120254355 A/G cg25214090 chr10:38739885 LOC399744 0.52 8.0 0.4 2.19e-14 Corneal astigmatism; CRC cis rs2404602 0.647 rs2404600 chr15:77173557 C/T cg23625390 chr15:77176239 SCAPER -0.86 -12.8 -0.58 9.96e-31 Blood metabolite levels; CRC cis rs2019137 0.905 rs2276561 chr2:113956371 G/C cg21550016 chr2:113992930 PAX8;LOC440839;LOC654433 -0.51 -7.28 -0.37 2.46e-12 Lymphocyte counts; CRC cis rs4730250 0.707 rs3729876 chr7:106786952 T/C cg02696742 chr7:106810147 HBP1 0.58 6.68 0.35 1.02e-10 Osteoarthritis; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg10542027 chr5:78532229 JMY 0.47 6.35 0.33 7.22e-10 Thyroid stimulating hormone; CRC cis rs3785574 0.962 rs2727331 chr17:61926990 G/T cg25654072 chr17:61904446 PSMC5;FTSJ3 0.43 5.97 0.31 6.07e-9 Height; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg26500144 chr6:36646390 CDKN1A 0.39 6.6 0.34 1.64e-10 Liver disease severity in Alagille syndrome; CRC cis rs11655198 1 rs11655198 chr17:38026169 C/T cg11212589 chr17:38028394 ZPBP2 0.46 8.71 0.43 1.5e-16 Asthma; CRC cis rs7847628 0.551 rs10818476 chr9:123572038 A/G cg09586646 chr9:123605570 PSMD5;LOC253039 0.84 14.73 0.63 4.46e-38 Birth weight; CRC cis rs7927592 0.913 rs67605986 chr11:68300955 C/T cg01657329 chr11:68192670 LRP5 -0.46 -6.58 -0.34 1.89e-10 Total body bone mineral density; CRC cis rs4819052 0.788 rs9978857 chr21:46705155 T/G cg19498844 chr21:46707878 POFUT2;LOC642852 0.73 10.44 0.5 3.07e-22 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs875971 1.000 rs4718307 chr7:65610988 A/G cg11764359 chr7:65958608 NA -0.62 -9.95 -0.48 1.43e-20 Aortic root size; CRC cis rs9649213 0.574 rs3801257 chr7:97991792 A/G cg00277769 chr7:97922759 BAIAP2L1 -0.6 -10.43 -0.5 3.32e-22 Prostate cancer (SNP x SNP interaction); CRC cis rs12630931 1.000 rs35280753 chr3:31978094 A/G cg21375017 chr3:31988082 OSBPL10 0.43 5.87 0.31 1.05e-8 Periodontal disease-related phenotypes; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg05935374 chr11:82782929 RAB30 0.45 6.7 0.35 9.25e-11 Intelligence (multi-trait analysis); CRC cis rs6121246 0.523 rs6060286 chr20:30197663 C/A cg13852791 chr20:30311386 BCL2L1 0.6 8.21 0.41 5.04e-15 Mean corpuscular hemoglobin; CRC cis rs3814231 0.531 rs12771689 chr10:115467068 A/G cg24846397 chr10:115438155 CASP7 -0.35 -5.75 -0.3 2.09e-8 Vitiligo; CRC cis rs55788414 0.932 rs35852981 chr16:81180897 G/A cg06400318 chr16:81190750 PKD1L2 -0.66 -6.45 -0.33 4.06e-10 Left ventricular obstructive tract defect (maternal effect); CRC cis rs6433857 0.627 rs6741769 chr2:181500545 G/A cg23363182 chr2:181467187 NA -0.58 -9.49 -0.46 5.01e-19 Body mass index; CRC cis rs9914988 0.943 rs11652272 chr17:27167973 C/G cg12682573 chr17:27188876 MIR451;MIR144 0.57 7.63 0.39 2.53e-13 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg00230368 chr6:160389833 IGF2R 0.46 6.66 0.34 1.17e-10 Intelligence (multi-trait analysis); CRC cis rs1552244 1.000 rs35220123 chr3:10083169 C/T cg10729496 chr3:10149963 C3orf24 0.55 7.11 0.37 7.07e-12 Alzheimer's disease; CRC cis rs1707322 0.963 rs12022335 chr1:46402732 C/A cg06784218 chr1:46089804 CCDC17 0.51 9.02 0.45 1.57e-17 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs3812762 0.783 rs11042070 chr11:8819367 C/T cg00186954 chr11:8933980 ST5;C11orf17 -0.54 -8.08 -0.41 1.21e-14 Hypospadias; CRC cis rs9467711 0.659 rs34246779 chr6:26549212 G/A cg12315302 chr6:26189340 HIST1H4D 0.99 6.93 0.36 2.22e-11 Autism spectrum disorder or schizophrenia; CRC cis rs4689388 0.926 rs10937719 chr4:6295322 C/G cg00701064 chr4:6280414 WFS1 0.75 12.48 0.57 1.54e-29 Type 2 diabetes and other traits;Type 2 diabetes; CRC cis rs6951245 0.935 rs112554101 chr7:1065535 A/G cg03188948 chr7:1209495 NA 0.53 6.19 0.32 1.82e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs853679 0.550 rs1233699 chr6:28169158 A/T cg23161317 chr6:28129485 ZNF389 0.45 5.92 0.31 8.06e-9 Depression; CRC cis rs2404602 0.647 rs62026889 chr15:76917885 C/T cg23625390 chr15:77176239 SCAPER -0.89 -14.12 -0.61 9.75e-36 Blood metabolite levels; CRC cis rs62229266 0.804 rs62230788 chr21:37380337 A/T cg12218747 chr21:37451666 NA -0.41 -6.85 -0.35 3.6e-11 Mitral valve prolapse; CRC cis rs9322193 0.962 rs10214845 chr6:150104260 A/G cg07701084 chr6:150067640 NUP43 0.47 6.61 0.34 1.51e-10 Lung cancer; CRC cis rs12134245 0.776 rs12122066 chr1:92005140 C/T cg02896835 chr1:92012615 NA -0.63 -11.33 -0.53 2.46e-25 Breast cancer; CRC cis rs12762955 0.507 rs7095853 chr10:1040798 T/C cg19847866 chr10:1019161 NA 0.4 5.82 0.31 1.43e-8 Response to angiotensin II receptor blocker therapy; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg02437376 chr10:76969880 VDAC2 0.46 6.33 0.33 7.85e-10 Response to antipsychotic treatment; CRC cis rs2836974 0.931 rs13625 chr21:40669083 G/T cg11890956 chr21:40555474 PSMG1 1.07 17.99 0.7 6.94e-51 Cognitive function; CRC cis rs6503525 0.628 rs62068171 chr17:38103242 G/A cg26162295 chr17:38119207 GSDMA -0.36 -6.54 -0.34 2.4e-10 Asthma; CRC cis rs172166 0.694 rs1770131 chr6:28086413 C/T cg20615401 chr6:28092323 ZSCAN16 0.45 5.9 0.31 9.1e-9 Cardiac Troponin-T levels; CRC cis rs2346177 0.554 rs13002880 chr2:46708129 C/G cg02822958 chr2:46747628 ATP6V1E2 0.41 5.75 0.3 2e-8 HDL cholesterol; CRC cis rs1215050 0.846 rs783923 chr4:98968686 C/T cg05340658 chr4:99064831 C4orf37 -0.44 -6.22 -0.32 1.51e-9 Waist-to-hip ratio adjusted for body mass index; CRC cis rs317689 0.690 rs607797 chr12:69646010 T/C cg14784868 chr12:69753453 YEATS4 0.47 5.93 0.31 7.51e-9 Response to diuretic therapy; CRC cis rs7635838 0.892 rs9310379 chr3:11434143 C/T cg00170343 chr3:11313890 ATG7 -0.37 -5.65 -0.3 3.44e-8 HDL cholesterol; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg14022721 chr22:25507536 KIAA1671 0.48 6.57 0.34 1.93e-10 Thyroid stimulating hormone; CRC cis rs4737010 0.501 rs12548116 chr8:41645074 A/G cg17182837 chr8:41585554 ANK1 -0.53 -7.21 -0.37 3.89e-12 Lymphocyte counts;High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Reticulocyte count;Reticulocyte fraction of red cells;Mean corpuscular volume;Immature fraction of reticulocytes;Mean corpuscular hemoglobin concentration; CRC cis rs875971 0.862 rs13232191 chr7:65986648 A/G cg18252515 chr7:66147081 NA -0.43 -6.21 -0.32 1.61e-9 Aortic root size; CRC cis rs7666738 0.830 rs7689495 chr4:98920152 T/C cg17366294 chr4:99064904 C4orf37 0.43 7.25 0.37 2.97e-12 Colonoscopy-negative controls vs population controls; CRC cis rs13108904 0.935 rs2199956 chr4:1248919 A/G cg05665937 chr4:1216051 CTBP1 0.4 6.06 0.32 3.65e-9 Obesity-related traits; CRC cis rs1799949 1.000 rs2037076 chr17:41305883 G/A cg19454999 chr17:41278357 BRCA1;NBR2 0.55 8.69 0.43 1.69e-16 Menopause (age at onset); CRC cis rs6502050 0.835 rs4789676 chr17:80123078 C/T cg09264619 chr17:80180166 NA -0.35 -5.93 -0.31 7.47e-9 Life satisfaction; CRC cis rs9649213 0.593 rs7812180 chr7:97969140 A/G cg00277769 chr7:97922759 BAIAP2L1 0.56 9.19 0.45 4.51e-18 Prostate cancer (SNP x SNP interaction); CRC cis rs447735 0.566 rs258337 chr16:89720710 T/A cg01097406 chr16:89675127 NA 0.44 8.42 0.42 1.21e-15 Hemoglobin concentration; CRC cis rs1163251 0.837 rs658442 chr1:120244858 T/G cg19096424 chr1:120255104 PHGDH 0.41 5.85 0.31 1.16e-8 Blood metabolite levels; CRC cis rs9487051 0.768 rs386696 chr6:109520166 G/A cg01475377 chr6:109611718 NA -0.34 -5.86 -0.31 1.12e-8 Reticulocyte fraction of red cells; CRC cis rs10045504 0.502 rs72746051 chr5:38759817 G/A cg15396434 chr5:38725168 NA -0.63 -6.14 -0.32 2.32e-9 Night sleep phenotypes; CRC cis rs9914544 1.000 rs1037036 chr17:18764077 C/T cg26306683 chr17:18585705 ZNF286B 0.53 7.15 0.37 5.76e-12 Educational attainment (years of education); CRC cis rs1451375 0.698 rs7797131 chr7:50647934 A/G cg14593290 chr7:50529359 DDC 0.51 7.11 0.37 7.09e-12 Malaria; CRC cis rs4900538 0.787 rs11704 chr14:102808655 C/G cg18135206 chr14:102964638 TECPR2 0.93 16.92 0.68 1.26e-46 Mean corpuscular volume;Mean corpuscular hemoglobin; CRC cis rs1568889 0.641 rs34857148 chr11:28481976 T/A cg06544937 chr11:28130018 METT5D1;KIF18A 0.61 7.13 0.37 6.51e-12 Bipolar disorder; CRC cis rs155076 0.666 rs2015241 chr13:21888254 A/G cg21970626 chr13:21893289 NA -0.46 -6.95 -0.36 1.96e-11 White matter hyperintensity burden; CRC trans rs2749592 0.513 rs1208708 chr10:38085576 A/G cg23533926 chr12:111358616 MYL2 -0.46 -6.76 -0.35 6.19e-11 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs6546324 0.580 rs4362541 chr2:67842866 A/T cg15745817 chr2:67799979 NA -0.56 -9.57 -0.47 2.59e-19 Endometriosis; CRC cis rs4713118 0.662 rs4713120 chr6:27721835 C/A cg12273811 chr6:28175739 NA 0.4 5.87 0.31 1.08e-8 Parkinson's disease; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg23489587 chr5:177303156 LOC728554 0.46 6.64 0.34 1.3e-10 Thyroid stimulating hormone; CRC cis rs7618915 0.547 rs11177 chr3:52721305 G/A cg10802521 chr3:52805072 NEK4 -0.58 -8.89 -0.44 4.25e-17 Bipolar disorder; CRC cis rs28386778 0.933 rs2665804 chr17:61951836 G/T cg25654072 chr17:61904446 PSMC5;FTSJ3 0.68 10.52 0.5 1.6400000000000001e-22 Prudent dietary pattern; CRC cis rs9322193 0.923 rs9800614 chr6:149965740 G/A cg00933542 chr6:150070202 PCMT1 0.31 6.25 0.33 1.29e-9 Lung cancer; CRC cis rs853679 0.546 rs200954 chr6:27838764 C/G cg23259851 chr6:27775964 HIST1H2AI;HIST1H2BL 0.71 5.93 0.31 7.83e-9 Depression; CRC cis rs896854 0.846 rs13254283 chr8:95914103 G/T cg23172400 chr8:95962367 TP53INP1 -0.45 -7.33 -0.37 1.85e-12 Type 2 diabetes; CRC cis rs6912958 0.525 rs586771 chr6:88064971 C/T cg12350822 chr6:88032061 C6orf162;GJB7 0.44 8.96 0.44 2.42e-17 Monocyte percentage of white cells; CRC cis rs1348850 0.668 rs6705405 chr2:178493713 A/G cg22681709 chr2:178499509 PDE11A -0.35 -5.81 -0.3 1.49e-8 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs9381040 0.610 rs6941090 chr6:41043465 G/A cg09580153 chr6:41068724 NFYA;LOC221442 -0.42 -5.94 -0.31 7.32e-9 Alzheimer's disease (late onset); CRC cis rs57221529 0.766 rs12519763 chr5:559145 C/T cg17948913 chr5:572064 NA 0.55 6.33 0.33 7.93e-10 Lung disease severity in cystic fibrosis; CRC cis rs720844 0.554 rs4972378 chr2:149335158 A/G cg09247360 chr2:149335327 NA 0.48 6.28 0.33 1.08e-9 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs7666738 0.830 rs9996098 chr4:98867740 T/C cg17366294 chr4:99064904 C4orf37 0.4 6.48 0.34 3.45e-10 Colonoscopy-negative controls vs population controls; CRC cis rs270601 0.739 rs1979981 chr5:131601720 G/A cg27615366 chr5:131592974 PDLIM4 0.34 6.46 0.34 3.73e-10 Acylcarnitine levels; CRC cis rs6761276 0.752 rs12477866 chr2:113835908 C/T cg24553058 chr2:113831203 IL1F10 0.39 6.3 0.33 9.43e-10 Protein quantitative trait loci; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg25724310 chr10:127512489 BCCIP;UROS 0.43 6.14 0.32 2.44e-9 Response to antipsychotic treatment; CRC trans rs587242 1.000 rs1853738 chr1:96895992 A/G cg10631902 chr5:14652156 NA 0.44 6.84 0.35 3.84e-11 Body mass index (joint analysis main effects and physical activity interaction);Body mass index in physically inactive individuals;Body mass index; CRC cis rs6120849 0.707 rs752075 chr20:33591591 C/A cg08999081 chr20:33150536 PIGU 0.46 5.88 0.31 9.91e-9 Protein C levels; CRC cis rs2153535 0.580 rs9405391 chr6:8466548 C/T cg07606381 chr6:8435919 SLC35B3 0.68 10.9 0.51 8.26e-24 Motion sickness; CRC cis rs7089973 0.604 rs11819372 chr10:116594934 A/G cg23260525 chr10:116636907 FAM160B1 0.38 9.04 0.45 1.34e-17 Bipolar disorder or attention deficit hyperactivity disorder; CRC cis rs6952808 0.792 rs2056480 chr7:1954301 A/G cg21782813 chr7:2030301 MAD1L1 -0.46 -7.9 -0.4 4.26e-14 Bipolar disorder and schizophrenia; CRC trans rs7395662 1.000 rs7129386 chr11:48616694 A/G cg21153622 chr11:89784906 NA -0.48 -7.68 -0.39 1.78e-13 HDL cholesterol; CRC cis rs270601 0.690 rs162904 chr5:131595784 C/T cg27615366 chr5:131592974 PDLIM4 -0.32 -5.68 -0.3 2.97e-8 Acylcarnitine levels; CRC trans rs9545047 0.645 rs9635027 chr13:79869673 G/A cg07061582 chr15:90234082 PEX11A;WDR93 0.42 5.99 0.31 5.57e-9 Schizophrenia; CRC cis rs1008375 1.000 rs10939742 chr4:17659936 G/T cg02297831 chr4:17616191 MED28 0.44 5.79 0.3 1.62e-8 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs11190604 1.000 rs11190552 chr10:102206607 G/A cg07570687 chr10:102243282 WNT8B 0.44 5.64 0.3 3.61e-8 Palmitoleic acid (16:1n-7) levels; CRC cis rs3733585 0.605 rs4697926 chr4:10124567 G/T cg11266682 chr4:10021025 SLC2A9 0.43 7.85 0.4 5.82e-14 Cleft plate (environmental tobacco smoke interaction); CRC cis rs8031584 0.918 rs61997140 chr15:31277312 A/G cg08109568 chr15:31115862 NA -0.54 -8.72 -0.43 1.45e-16 Huntington's disease progression; CRC cis rs12477438 0.715 rs7586608 chr2:99558017 G/A cg26064155 chr2:99771622 LIPT1;TSGA10 -0.6 -8.28 -0.42 3.03e-15 Chronic sinus infection; CRC cis rs765787 0.530 rs4774542 chr15:45526026 A/C cg24006582 chr15:45444508 DUOX1 0.53 7.7 0.39 1.6e-13 Uric acid levels; CRC trans rs877282 0.945 rs12776447 chr10:790625 A/G cg22713356 chr15:30763199 NA 1.34 16.68 0.68 1.08e-45 Uric acid levels; CRC cis rs929354 0.772 rs1182360 chr7:157020550 C/G cg05182265 chr7:156933206 UBE3C -0.77 -14.67 -0.63 7.87e-38 Body mass index; CRC cis rs9914988 0.943 rs9907178 chr17:27124307 G/C cg12682573 chr17:27188876 MIR451;MIR144 0.58 7.99 0.4 2.37e-14 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs7927592 0.513 rs7950129 chr11:68202903 A/G cg16797656 chr11:68205561 LRP5 0.6 11.22 0.53 5.7e-25 Total body bone mineral density; CRC cis rs7552404 0.731 rs10732723 chr1:76392437 C/T cg22875332 chr1:76189707 ACADM -0.53 -6.72 -0.35 8.03e-11 Blood metabolite levels;Acylcarnitine levels; CRC cis rs875971 0.862 rs10278014 chr7:66051264 C/T cg00343986 chr7:65444356 GUSB -0.45 -6.22 -0.32 1.53e-9 Aortic root size; CRC cis rs4713118 0.527 rs4713151 chr6:28136356 G/A cg02631126 chr6:28058918 ZSCAN12L1 0.29 5.91 0.31 8.38e-9 Parkinson's disease; CRC cis rs4853012 0.838 rs60964317 chr2:74343423 A/T cg01017244 chr2:74357527 NA 0.63 8.75 0.43 1.14e-16 Gestational age at birth (maternal effect); CRC cis rs9322193 0.607 rs4870078 chr6:150201812 A/G cg13206674 chr6:150067644 NUP43 -0.48 -5.8 -0.3 1.55e-8 Lung cancer; CRC cis rs2298450 0.550 rs9974155 chr21:37654390 C/T cg02919814 chr21:37666008 DOPEY2 -0.44 -6.43 -0.33 4.4e-10 Schizophrenia; CRC cis rs11628318 0.614 rs8010455 chr14:103164681 A/G cg08075719 chr14:103021372 NA 0.65 7.52 0.38 5.42e-13 Platelet count; CRC cis rs28386778 0.897 rs2236737 chr17:61938100 C/T cg06873352 chr17:61820015 STRADA 0.73 13.55 0.6 1.55e-33 Prudent dietary pattern; CRC cis rs4664293 0.867 rs6761145 chr2:160582184 A/C cg08347373 chr2:160653686 CD302 -0.47 -7.43 -0.38 9.32e-13 Monocyte percentage of white cells; CRC cis rs7909074 0.531 rs879343 chr10:45400707 G/T cg05187965 chr10:45406764 TMEM72 -0.34 -6.76 -0.35 6.22e-11 Mean corpuscular volume; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg27576415 chr15:41709087 RTF1 0.56 7.42 0.38 1e-12 Thyroid stimulating hormone; CRC cis rs1448094 0.512 rs60986162 chr12:86247054 T/G cg19622623 chr12:86230825 RASSF9 -0.41 -6.76 -0.35 6.45e-11 Major depressive disorder; CRC cis rs1218582 0.804 rs869506 chr1:154859581 A/C cg09359103 chr1:154839909 KCNN3 -0.73 -13.14 -0.59 5.32e-32 Prostate cancer; CRC cis rs6570726 0.905 rs375692 chr6:145840368 A/G cg23711669 chr6:146136114 FBXO30 0.68 11.87 0.55 2.68e-27 Lobe attachment (rater-scored or self-reported); CRC cis rs364477 0.547 rs438294 chr9:979611 A/T cg13952963 chr9:998547 NA 0.5 6.2 0.32 1.7e-9 Major depressive disorder; CRC cis rs7618915 0.501 rs10865974 chr3:52718280 A/C cg10802521 chr3:52805072 NEK4 0.56 8.82 0.44 6.65e-17 Bipolar disorder; CRC cis rs10504229 0.728 rs17216187 chr8:58158778 G/T cg20607798 chr8:58055168 NA 0.46 5.69 0.3 2.79e-8 Developmental language disorder (linguistic errors); CRC cis rs6088580 0.634 rs4911421 chr20:32998948 T/C cg24642439 chr20:33292090 TP53INP2 -0.37 -6.31 -0.33 8.76e-10 Glomerular filtration rate (creatinine); CRC cis rs1059312 0.808 rs4760533 chr12:129297651 A/G cg09035930 chr12:129282057 SLC15A4 -0.52 -8.81 -0.44 7.2e-17 Systemic lupus erythematosus; CRC trans rs1945213 0.694 rs10895985 chr11:55831595 T/C cg03929089 chr4:120376271 NA 0.56 6.39 0.33 5.59e-10 Acute lymphoblastic leukemia (childhood); CRC cis rs919433 0.783 rs788011 chr2:198230771 A/G cg10820045 chr2:198174542 NA 0.45 8.01 0.4 1.99e-14 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC cis rs7223966 1.000 rs56383601 chr17:61929968 A/C cg23090583 chr17:61904693 PSMC5;FTSJ3 0.6 7.31 0.37 2.04e-12 Hip circumference adjusted for BMI;Body mass index; CRC cis rs13191362 0.688 rs73035006 chr6:162997083 G/T cg06582575 chr6:163149167 PACRG;PARK2 0.77 10.7 0.51 3.98e-23 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs2735413 0.918 rs1922621 chr16:78075015 A/G cg04733911 chr16:78082701 NA -0.43 -7.08 -0.36 8.69e-12 Systolic blood pressure (alcohol consumption interaction); CRC cis rs9649465 0.561 rs688242 chr7:123420442 C/A cg03229431 chr7:123269106 ASB15 0.59 9.55 0.47 2.98e-19 Migraine; CRC trans rs1997103 0.906 rs6593232 chr7:55402916 C/T cg20935933 chr6:143382018 AIG1 0.52 6.72 0.35 7.8e-11 QRS interval (sulfonylurea treatment interaction); CRC cis rs9322817 0.902 rs7764251 chr6:105197091 G/T cg02098413 chr6:105308735 HACE1 -0.36 -6.58 -0.34 1.9e-10 Thyroid stimulating hormone; CRC cis rs25422 0.938 rs9489443 chr6:118886163 T/A cg10217327 chr6:118973057 C6orf204 0.51 5.85 0.31 1.21e-8 Renal cell carcinoma; CRC cis rs9916302 0.904 rs9944411 chr17:37483599 T/C cg00129232 chr17:37814104 STARD3 0.53 7.8 0.4 8.22e-14 Glomerular filtration rate (creatinine); CRC trans rs11098499 0.708 rs11732686 chr4:120252330 C/A cg25214090 chr10:38739885 LOC399744 0.53 8.36 0.42 1.81e-15 Corneal astigmatism; CRC cis rs4481887 0.508 rs4390207 chr1:248400174 C/T cg00666640 chr1:248458726 OR2T12 0.45 7.14 0.37 6.09e-12 Common traits (Other); CRC cis rs4588572 0.643 rs7716529 chr5:77738637 A/T cg11547950 chr5:77652471 NA -0.51 -7.09 -0.36 8.03e-12 Triglycerides; CRC cis rs782590 0.967 rs1823893 chr2:55788921 T/C cg18811423 chr2:55921094 PNPT1 0.8 14.67 0.63 8.01e-38 Metabolic syndrome; CRC cis rs4466137 0.951 rs336958 chr5:82973396 A/G cg16102102 chr5:83017553 HAPLN1 -0.48 -6.43 -0.33 4.53e-10 Prostate cancer; CRC trans rs561341 0.941 rs72825746 chr17:30364610 G/A cg20587970 chr11:113659929 NA -1.41 -19.88 -0.74 2.49e-58 Hip circumference adjusted for BMI; CRC cis rs938554 0.657 rs9994216 chr4:9984541 G/T cg00071950 chr4:10020882 SLC2A9 0.44 6.64 0.34 1.33e-10 Blood metabolite levels; CRC cis rs4862750 0.872 rs4862748 chr4:187877388 C/T cg27532560 chr4:187881888 NA 0.47 7.64 0.39 2.41e-13 Lobe attachment (rater-scored or self-reported); CRC cis rs3806843 0.576 rs246011 chr5:140336405 G/C cg19875535 chr5:140030758 IK 0.4 6.12 0.32 2.64e-9 Depressive symptoms (multi-trait analysis); CRC cis rs950169 1.000 rs35648189 chr15:84740748 T/C cg17507749 chr15:85114479 UBE2QP1 0.77 11.93 0.55 1.64e-27 Schizophrenia; CRC cis rs9326248 0.954 rs10790177 chr11:117048417 A/G cg11861562 chr11:117069780 TAGLN 0.41 9.38 0.46 1.08e-18 Blood protein levels; CRC cis rs7072216 0.763 rs3814140 chr10:100170762 C/T cg26618903 chr10:100175079 PYROXD2 -0.55 -9.16 -0.45 5.81e-18 Metabolite levels; CRC cis rs79349575 0.594 rs1985785 chr17:46967788 T/C cg00947319 chr17:47005597 UBE2Z -0.33 -5.7 -0.3 2.6e-8 Type 2 diabetes; CRC cis rs4481887 1.000 rs4306162 chr1:248468509 C/T cg13385794 chr1:248469461 NA 0.38 6.8 0.35 5.07e-11 Common traits (Other); CRC cis rs8072100 0.666 rs9913503 chr17:45776330 T/G cg19784903 chr17:45786737 TBKBP1 -0.35 -5.75 -0.3 2.08e-8 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs10979 1.000 rs35354710 chr6:143886454 A/G cg25407410 chr6:143891975 LOC285740 -0.81 -13.2 -0.59 3.24e-32 Hypospadias; CRC cis rs4555082 0.830 rs2255575 chr14:105727251 T/C cg06808227 chr14:105710500 BRF1 -0.63 -9.18 -0.45 5.04e-18 Mean platelet volume;Platelet distribution width; CRC cis rs1862618 0.853 rs832578 chr5:56164223 C/T cg24531977 chr5:56204891 C5orf35 -0.82 -10.76 -0.51 2.52e-23 Initial pursuit acceleration; CRC trans rs9956878 0.555 rs8085188 chr18:73544676 A/G cg22719782 chr11:114310057 REXO2 -0.41 -6.34 -0.33 7.39e-10 Obesity-related traits; CRC cis rs6723226 0.766 rs398290 chr2:32503526 T/C cg02381751 chr2:32503542 YIPF4 0.62 8.95 0.44 2.67e-17 Intelligence (multi-trait analysis); CRC cis rs6951245 1.000 rs111899361 chr7:1112348 C/T cg26224354 chr7:1096374 C7orf50;GPR146 -0.95 -12.37 -0.56 4.18e-29 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs881375 0.967 rs2416806 chr9:123690292 G/C cg14255062 chr9:123606675 PSMD5;LOC253039 0.41 5.95 0.31 6.81e-9 Rheumatoid arthritis; CRC cis rs274567 0.501 rs274571 chr5:131712125 A/G cg24060327 chr5:131705240 SLC22A5 0.54 8.11 0.41 9.81e-15 Blood metabolite levels; CRC cis rs2019137 0.560 rs7578633 chr2:113978650 C/T cg11763394 chr2:113992921 PAX8;LOC440839;LOC654433 0.69 10.43 0.5 3.35e-22 Lymphocyte counts; CRC cis rs1401999 0.628 rs7639048 chr3:183746044 A/G cg20387954 chr3:183756860 HTR3D 0.38 6.47 0.34 3.52e-10 Anterior chamber depth; CRC cis rs11809207 0.574 rs2783633 chr1:26505265 A/G cg00147160 chr1:26503991 CNKSR1 0.29 6.05 0.32 4.03e-9 Height; CRC cis rs6570726 0.935 rs432086 chr6:145841593 C/T cg05347473 chr6:146136440 FBXO30 -0.38 -6.05 -0.32 3.95e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs2576037 0.526 rs1893427 chr18:44434987 C/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.54 9.18 0.45 4.82e-18 Personality dimensions; CRC cis rs2732480 0.537 rs1061986 chr12:48736439 T/C cg24011408 chr12:48396354 COL2A1 0.47 6.39 0.33 5.64e-10 Hemoglobin concentration;Red blood cell count;Hematocrit; CRC cis rs1448094 0.512 rs6539928 chr12:86244920 G/A cg19622623 chr12:86230825 RASSF9 -0.42 -6.78 -0.35 5.42e-11 Major depressive disorder; CRC cis rs9549260 0.755 rs7988604 chr13:41215802 G/T cg21288729 chr13:41239152 FOXO1 0.48 7.56 0.38 4.03e-13 Red blood cell count; CRC cis rs6570726 0.764 rs367065 chr6:145882309 T/G cg23711669 chr6:146136114 FBXO30 0.77 13.41 0.59 5.08e-33 Lobe attachment (rater-scored or self-reported); CRC cis rs10256972 0.552 rs2949192 chr7:1203841 C/T cg22907277 chr7:1156413 C7orf50 0.62 9.59 0.47 2.21e-19 Longevity;Endometriosis; CRC cis rs13256369 1.000 rs13256369 chr8:8577379 T/C cg06636001 chr8:8085503 FLJ10661 0.45 5.79 0.3 1.66e-8 Obesity-related traits; CRC cis rs2580764 0.566 rs2968793 chr2:55285024 C/T cg09592903 chr2:55203963 RTN4 0.71 11.19 0.52 7.85e-25 Mean platelet volume; CRC cis rs2576037 0.526 rs9962523 chr18:44486414 A/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.54 8.97 0.44 2.23e-17 Personality dimensions; CRC cis rs1129187 0.837 rs3763236 chr6:42902508 C/T cg03790207 chr6:42947109 PEX6 0.4 5.79 0.3 1.63e-8 Alzheimer's disease in APOE e4+ carriers; CRC cis rs10931896 0.531 rs296801 chr2:201142812 C/T cg23649088 chr2:200775458 C2orf69 0.45 6.3 0.33 9.5e-10 Systolic blood pressure; CRC cis rs1577917 1.000 rs12200330 chr6:86656653 G/A cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.51 -6.41 -0.33 4.97e-10 Response to antipsychotic treatment; CRC cis rs758324 0.947 rs1500114 chr5:131138120 C/A cg06307176 chr5:131281290 NA 0.45 6.6 0.34 1.65e-10 Alzheimer's disease in APOE e4- carriers; CRC cis rs9403521 1.000 rs9390126 chr6:143980432 A/G cg18240653 chr6:144019428 PHACTR2 -0.58 -6.67 -0.35 1.06e-10 Obesity-related traits; CRC cis rs898097 0.578 rs6502021 chr17:80907728 T/C cg15369054 chr17:80825471 TBCD -0.36 -5.97 -0.31 6.27e-9 Breast cancer; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg21757043 chr3:128444882 RAB7A 0.51 7.58 0.39 3.5e-13 Response to antipsychotic treatment; CRC cis rs1559088 0.947 rs10403238 chr19:33552405 A/G cg27124370 chr19:33622961 WDR88 0.4 5.64 0.3 3.76e-8 Bone ultrasound measurement (broadband ultrasound attenuation); CRC cis rs3733585 0.673 rs4580649 chr4:9948461 G/A cg11266682 chr4:10021025 SLC2A9 -0.45 -8.99 -0.44 1.96e-17 Cleft plate (environmental tobacco smoke interaction); CRC cis rs9322193 0.923 rs12529698 chr6:149972087 G/A cg13206674 chr6:150067644 NUP43 0.68 10.19 0.49 2.26e-21 Lung cancer; CRC cis rs1797081 0.561 rs2603795 chr10:16860256 A/G cg23933602 chr10:16859644 RSU1 0.61 8.69 0.43 1.75e-16 Platelet distribution width; CRC cis rs4713118 0.513 rs149897 chr6:28006650 A/G cg02631126 chr6:28058918 ZSCAN12L1 0.23 5.61 0.3 4.38e-8 Parkinson's disease; CRC cis rs1448094 0.511 rs7139088 chr12:86147878 T/C cg06740227 chr12:86229804 RASSF9 -0.37 -5.64 -0.3 3.71e-8 Major depressive disorder; CRC cis rs473651 0.935 rs558924 chr2:239339511 A/G cg08773314 chr2:239334832 ASB1 0.37 7.75 0.39 1.15e-13 Multiple system atrophy; CRC cis rs6500602 0.564 rs3747584 chr16:4516092 A/G cg14951292 chr16:4525986 HMOX2;NMRAL1 0.73 10.21 0.49 1.91e-21 Schizophrenia; CRC cis rs274567 0.602 rs272853 chr5:131688561 A/G cg22638593 chr5:131593259 PDLIM4 0.36 6.12 0.32 2.7e-9 Blood metabolite levels; CRC cis rs4563143 0.514 rs112540771 chr19:29316100 C/T cg12667521 chr19:29218732 NA 0.47 6.64 0.34 1.27e-10 Methadone dose in opioid dependence; CRC cis rs9303401 0.703 rs9909925 chr17:57210069 C/T cg02118635 chr17:56770003 RAD51C;TEX14 -0.47 -7.14 -0.37 6.19e-12 Cognitive test performance; CRC cis rs1799949 1.000 rs33946455 chr17:41321846 C/T cg25072359 chr17:41440525 NA 0.46 6.96 0.36 1.86e-11 Menopause (age at onset); CRC cis rs909674 0.541 rs5757655 chr22:39797178 C/G cg25956985 chr22:39795188 MAP3K7IP1 0.43 6.35 0.33 7.17e-10 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; CRC cis rs10504229 0.683 rs2005392 chr8:58106896 T/C cg22535103 chr8:58192502 C8orf71 -0.69 -8.8 -0.44 7.79e-17 Developmental language disorder (linguistic errors); CRC cis rs4332037 0.538 rs4721164 chr7:1932629 C/G cg25834613 chr7:1915315 MAD1L1 -0.4 -6.47 -0.34 3.58e-10 Bipolar disorder; CRC cis rs6842789 0.545 rs12642448 chr4:124921046 T/C cg01723706 chr4:124814442 LOC285419 0.42 5.69 0.3 2.86e-8 Neuroticism; CRC cis rs10504229 1.000 rs66870803 chr8:58180022 G/C cg22535103 chr8:58192502 C8orf71 -0.82 -12.27 -0.56 9.63e-29 Developmental language disorder (linguistic errors); CRC cis rs7811142 1.000 rs67471932 chr7:100009985 C/G cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.74 10.28 0.49 1.11e-21 Platelet count; CRC trans rs6089829 0.962 rs2277769 chr20:61666805 C/T cg23505145 chr19:12996616 KLF1 0.48 7.8 0.4 8.3e-14 Prostate cancer (SNP x SNP interaction); CRC trans rs9929218 0.859 rs9936682 chr16:68748223 A/G cg04657470 chr2:198365150 HSPE1;HSPD1 -0.92 -12.3 -0.56 7.49e-29 Colorectal cancer; CRC cis rs62244186 0.659 rs56231820 chr3:44530329 C/T cg10263370 chr3:44754102 ZNF502 -0.37 -6.09 -0.32 3.12e-9 Depressive symptoms; CRC cis rs9393692 0.645 rs4145910 chr6:26313305 T/C cg13736514 chr6:26305472 NA -0.67 -11.64 -0.54 1.91e-26 Educational attainment; CRC cis rs4862750 0.872 rs9998173 chr4:187898778 T/A cg03647317 chr4:187891568 NA -0.55 -10.22 -0.49 1.83e-21 Lobe attachment (rater-scored or self-reported); CRC cis rs16867321 0.950 rs1919155 chr2:181457053 T/C cg23363182 chr2:181467187 NA -0.56 -7.17 -0.37 5.02e-12 Obesity; CRC cis rs731174 0.797 rs510208 chr1:38147166 A/G cg06917450 chr1:38156652 C1orf109 -0.5 -6.97 -0.36 1.71e-11 Prostate cancer (SNP x SNP interaction); CRC trans rs3001167 1.000 rs3009387 chr1:194552725 A/G cg19011063 chr5:170171465 NA 0.56 6.11 0.32 2.87e-9 Obesity-related traits; CRC cis rs875971 0.545 rs11770063 chr7:65783016 G/A cg03233332 chr7:66118400 NA -0.42 -5.83 -0.31 1.34e-8 Aortic root size; CRC cis rs1215050 0.791 rs165250 chr4:98696259 G/A cg05340658 chr4:99064831 C4orf37 0.47 6.95 0.36 1.95e-11 Waist-to-hip ratio adjusted for body mass index; CRC cis rs12220238 1.000 rs11000888 chr10:75901929 G/C cg19889307 chr10:75911429 ADK;AP3M1 0.62 6.04 0.32 4.19e-9 Soluble interleukin-2 receptor subunit alpha; CRC cis rs6088590 0.561 rs2295444 chr20:33173883 C/T cg08999081 chr20:33150536 PIGU 0.64 12.42 0.56 2.68e-29 Coronary artery disease; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg11922371 chr17:48226442 PPP1R9B 0.47 6.58 0.34 1.82e-10 Response to antipsychotic treatment; CRC cis rs9648716 1.000 rs964942 chr7:140622355 T/C cg10747023 chr7:140774559 NA 0.46 6.02 0.31 4.76e-9 Type 2 diabetes; CRC cis rs9303280 0.719 rs56750287 chr17:38062944 A/C cg11212589 chr17:38028394 ZPBP2 0.42 7.65 0.39 2.19e-13 Self-reported allergy; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg08723769 chr16:89627049 RPL13;SNORD68 -0.4 -6.4 -0.33 5.41e-10 Myopia (pathological); CRC cis rs11229555 0.645 rs7930547 chr11:58197616 A/C cg15696309 chr11:58395628 NA -0.82 -10.45 -0.5 2.81e-22 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; CRC cis rs1799949 1.000 rs4340367 chr17:41307772 G/A cg01879757 chr17:41196368 BRCA1 -0.43 -6.53 -0.34 2.51e-10 Menopause (age at onset); CRC cis rs17711722 0.585 rs6942660 chr7:65302406 C/T cg02869306 chr7:64672164 INTS4L1 -0.34 -5.77 -0.3 1.83e-8 Calcium levels; CRC trans rs7819412 0.595 rs10106914 chr8:10987651 T/G cg16141378 chr3:129829833 LOC729375 0.43 6.55 0.34 2.27e-10 Triglycerides; CRC cis rs11971779 0.680 rs9683 chr7:139107739 T/A cg07862535 chr7:139043722 LUC7L2 0.57 7.32 0.37 1.92e-12 Diisocyanate-induced asthma; CRC cis rs3806843 0.576 rs246029 chr5:140333226 G/A cg19875535 chr5:140030758 IK 0.4 6.12 0.32 2.64e-9 Depressive symptoms (multi-trait analysis); CRC cis rs3767633 0.858 rs10753645 chr1:161815364 T/C cg09175582 chr1:161736000 ATF6 0.7 6.29 0.33 1.03e-9 IgG glycosylation; CRC cis rs10512697 0.892 rs71594958 chr5:3540342 G/A cg19473799 chr5:3511975 NA -0.79 -6.17 -0.32 1.99e-9 Immune response to smallpox vaccine (IL-6); CRC cis rs7044106 0.791 rs10984998 chr9:123481516 G/C cg09586646 chr9:123605570 PSMD5;LOC253039 0.66 9.79 0.47 4.99e-20 Hip circumference adjusted for BMI; CRC cis rs7666738 0.830 rs62321587 chr4:98997958 T/C cg05340658 chr4:99064831 C4orf37 0.61 9.54 0.47 3.44e-19 Colonoscopy-negative controls vs population controls; CRC cis rs17125944 0.686 rs6572868 chr14:53325090 C/T cg00686598 chr14:53173677 PSMC6 -0.6 -5.8 -0.3 1.57e-8 Alzheimer's disease (late onset); CRC cis rs10256972 0.621 rs10951594 chr7:1088607 C/G cg03923535 chr7:1197113 ZFAND2A 0.55 8.01 0.4 1.96e-14 Longevity;Endometriosis; CRC cis rs926938 0.501 rs360686 chr1:115502524 C/T cg12756093 chr1:115239321 AMPD1 0.47 6.58 0.34 1.81e-10 Autism; CRC cis rs394563 0.591 rs11155641 chr6:149648595 G/A cg11245181 chr6:149772854 ZC3H12D 0.58 10.21 0.49 1.95e-21 Dupuytren's disease; CRC trans rs4363385 0.693 rs76987906 chr1:152964530 A/G cg03800765 chr3:11313984 ATG7 -0.41 -6.1 -0.32 2.9e-9 Inflammatory skin disease; CRC cis rs10883723 0.810 rs12265877 chr10:104247247 C/G cg11453585 chr10:104263688 ACTR1A;SUFU 0.91 17.37 0.69 2.02e-48 Allergic disease (asthma, hay fever or eczema); CRC cis rs1129187 1.000 rs1129187 chr6:42932200 G/T cg02353165 chr6:42928485 GNMT 0.86 15.79 0.66 3.32e-42 Alzheimer's disease in APOE e4+ carriers; CRC cis rs7618915 0.547 rs12487591 chr3:52642936 A/T cg18099408 chr3:52552593 STAB1 -0.44 -7.32 -0.37 1.89e-12 Bipolar disorder; CRC cis rs2197308 0.692 rs1904964 chr12:37933241 T/A cg13010199 chr12:38710504 ALG10B 0.45 5.75 0.3 2.07e-8 Morning vs. evening chronotype; CRC cis rs2976388 0.609 rs2585140 chr8:143806896 A/G cg22687807 chr8:143858763 LYNX1 0.5 8.91 0.44 3.48e-17 Urinary tract infection frequency; CRC cis rs7412746 0.658 rs3768016 chr1:150809919 T/C cg10589385 chr1:150898437 SETDB1 0.32 6.56 0.34 2.08e-10 Melanoma; CRC cis rs12477438 0.501 rs12995473 chr2:99764884 G/T cg26064155 chr2:99771622 LIPT1;TSGA10 0.83 14.66 0.63 8.22e-38 Chronic sinus infection; CRC cis rs7618915 0.547 rs12496476 chr3:52708737 A/G cg05573699 chr3:52720067 GNL3;PBRM1 -0.45 -6.32 -0.33 8.47e-10 Bipolar disorder; CRC trans rs2055729 0.677 rs13270146 chr8:9740595 C/T cg06636001 chr8:8085503 FLJ10661 -0.49 -6.58 -0.34 1.89e-10 Multiple myeloma (hyperdiploidy); CRC cis rs7927771 0.965 rs35985502 chr11:47847428 G/A cg05585544 chr11:47624801 NA -0.61 -10.84 -0.51 1.25e-23 Subjective well-being; CRC trans rs9467711 1.000 rs6923139 chr6:26313348 C/T cg15845792 chr6:28175446 NA 0.67 6.48 0.34 3.34e-10 Autism spectrum disorder or schizophrenia; CRC cis rs1577917 0.958 rs1591437 chr6:86525305 T/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.55 -6.85 -0.35 3.59e-11 Response to antipsychotic treatment; CRC cis rs7937682 0.575 rs7114617 chr11:111768173 A/T cg19812747 chr11:111475976 SIK2 0.43 6.35 0.33 6.97e-10 Primary sclerosing cholangitis; CRC cis rs1867631 0.585 rs12094526 chr1:67126114 A/G cg02459107 chr1:67143332 SGIP1 0.36 6.3 0.33 9.31e-10 Menopause (age at onset); CRC cis rs9913156 0.515 rs11658808 chr17:4577112 C/T cg19197139 chr17:4613644 ARRB2 -0.59 -8.59 -0.43 3.59e-16 Lymphocyte counts; CRC cis rs4654899 0.865 rs4654891 chr1:21286391 T/C cg02927042 chr1:21476669 EIF4G3 -0.51 -8.05 -0.41 1.53e-14 Superior frontal gyrus grey matter volume; CRC cis rs9522267 0.535 rs4644738 chr13:112235995 G/A cg14352298 chr13:112236639 NA 0.29 6.74 0.35 7.32e-11 Hepatitis; CRC trans rs2303319 0.504 rs62189055 chr2:162625749 C/A cg13034943 chr12:132379564 ULK1 -0.69 -5.96 -0.31 6.33e-9 Cognitive function; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg04119843 chr1:1284268 DVL1 0.49 6.99 0.36 1.51e-11 Response to antipsychotic treatment; CRC cis rs7827545 1.000 rs6995244 chr8:135568959 A/G cg07299736 chr8:135490787 ZFAT -0.38 -6.44 -0.33 4.31e-10 Hypertension (SNP x SNP interaction); CRC cis rs12760731 0.623 rs10913539 chr1:178336682 T/C cg00404053 chr1:178313656 RASAL2 0.75 9.45 0.46 6.51e-19 Obesity-related traits; CRC cis rs6565180 0.926 rs12446288 chr16:30388709 A/G cg17640201 chr16:30407289 ZNF48 0.86 15.76 0.66 4.38e-42 Tonsillectomy; CRC cis rs8067545 0.611 rs12936443 chr17:20033446 T/G cg13482628 chr17:19912719 NA 0.44 6.79 0.35 5.15e-11 Schizophrenia; CRC cis rs11098499 0.954 rs66506550 chr4:120371445 T/A cg24375607 chr4:120327624 NA 0.51 7.98 0.4 2.49e-14 Corneal astigmatism; CRC cis rs7208859 0.524 rs77498725 chr17:29063986 C/T cg13385521 chr17:29058706 SUZ12P 0.72 8.17 0.41 6.77e-15 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs7932354 0.583 rs4294527 chr11:46828799 A/T cg19486271 chr11:47235900 DDB2 -0.43 -6.48 -0.34 3.3e-10 Bone mineral density (hip);Bone mineral density; CRC cis rs9921222 1.000 rs10794639 chr16:377367 A/G cg00101154 chr16:420108 MRPL28 -0.5 -7.33 -0.37 1.81e-12 Bone mineral density (spine);Bone mineral density; CRC cis rs9462027 0.628 rs9462015 chr6:34739726 T/G cg07306190 chr6:34760872 UHRF1BP1 -0.35 -6.25 -0.33 1.28e-9 Systemic lupus erythematosus; CRC cis rs2204008 0.715 rs12368462 chr12:38336116 C/G cg13010199 chr12:38710504 ALG10B 0.46 6.16 0.32 2.07e-9 Bladder cancer; CRC cis rs7726839 0.540 rs72703092 chr5:599269 G/A cg17948913 chr5:572064 NA 0.51 5.88 0.31 1.01e-8 Obesity-related traits; CRC cis rs4332037 0.762 rs11770612 chr7:1915493 A/C cg23422044 chr7:1970798 MAD1L1 -0.59 -7.82 -0.4 7.47e-14 Bipolar disorder; CRC cis rs11191205 0.644 rs75972556 chr10:103377022 G/A cg15320455 chr10:103880129 LDB1 0.57 6.18 0.32 1.87e-9 Intelligence (multi-trait analysis); CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg21819024 chr1:52344978 NRD1 -0.52 -6.42 -0.33 4.77e-10 Diisocyanate-induced asthma; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg16015499 chr1:159888603 TAGLN2 -0.41 -6.53 -0.34 2.43e-10 Liver disease severity in Alagille syndrome; CRC trans rs10982213 0.830 rs2274163 chr9:117188714 C/T cg21678189 chr6:10838625 NA 0.4 6.17 0.32 2.02e-9 Interleukin-6 levels; CRC cis rs2302190 0.882 rs7213415 chr17:56672433 C/G cg12560992 chr17:57184187 TRIM37 0.53 6.17 0.32 1.98e-9 Vitamin D levels; CRC cis rs798554 0.797 rs1182183 chr7:2873136 C/T cg04166393 chr7:2884313 GNA12 0.53 7.25 0.37 3.02e-12 Height; CRC trans rs1005277 0.579 rs2103938 chr10:38493998 T/G cg27523141 chr10:43048294 ZNF37B 0.47 6.91 0.36 2.55e-11 Extrinsic epigenetic age acceleration; CRC cis rs929596 0.793 rs13009407 chr2:234652347 C/G cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.69 -8.46 -0.42 9.03e-16 Total bilirubin levels in HIV-1 infection; CRC cis rs939584 1.000 rs7560246 chr2:643469 T/C cg03610516 chr2:642275 NA 0.42 5.88 0.31 9.94e-9 Body mass index; CRC cis rs68170813 0.559 rs12532967 chr7:106937418 T/C cg02696742 chr7:106810147 HBP1 -0.61 -6.7 -0.35 9.06e-11 Coronary artery disease; CRC cis rs9902453 0.817 rs59420007 chr17:28196114 T/C cg26525008 chr17:28256777 EFCAB5;SSH2 0.57 8.6 0.43 3.26e-16 Coffee consumption (cups per day); CRC cis rs12477438 0.765 rs62156363 chr2:99693324 G/A cg26064155 chr2:99771622 LIPT1;TSGA10 -0.63 -8.55 -0.43 4.61e-16 Chronic sinus infection; CRC cis rs12044355 1.000 rs12044355 chr1:231844347 A/C cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX 0.44 5.99 0.31 5.54e-9 Alzheimer's disease; CRC cis rs3785574 0.962 rs7219920 chr17:61811642 C/G cg11494091 chr17:61959527 GH2 0.37 5.79 0.3 1.64e-8 Height; CRC cis rs11212617 0.967 rs227072 chr11:108212093 A/C cg12106634 chr11:108092400 ATM;NPAT 0.43 6.43 0.33 4.42e-10 Response to metformin in type 2 diabetes (glycemic); CRC cis rs1949733 1.000 rs2688233 chr4:8491885 T/C cg13073564 chr4:8508604 NA -0.51 -7.71 -0.39 1.5e-13 Response to antineoplastic agents; CRC cis rs7662987 0.517 rs2851286 chr4:100014976 A/G cg12011299 chr4:100065546 ADH4 -0.49 -9.32 -0.46 1.74e-18 Smoking initiation; CRC cis rs57143961 1 rs57143961 chr19:16533225 C/CT cg10248733 chr19:16607483 C19orf44;CALR3 -0.64 -7.13 -0.37 6.46e-12 Lymphocyte percentage of white cells; CRC cis rs4713118 0.621 rs9295755 chr6:28033174 C/T cg25164649 chr6:28176230 NA -0.67 -8.54 -0.43 4.92e-16 Parkinson's disease; CRC trans rs17033702 0.585 rs12615683 chr2:67737466 A/C cg11936311 chr5:178957434 NA 0.34 6.51 0.34 2.82e-10 Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for BMI in active individuals; CRC cis rs908922 0.651 rs7529157 chr1:152531365 C/A cg23254163 chr1:152506842 NA 0.45 9.15 0.45 6.31e-18 Hair morphology; CRC cis rs6732160 0.932 rs6546802 chr2:73379564 G/A cg01422370 chr2:73384389 NA 0.33 5.67 0.3 3.17e-8 Intelligence (multi-trait analysis); CRC cis rs6565681 0.760 rs9901680 chr17:78378088 A/G cg15383979 chr17:78362278 RNF213;LOC100294362 -0.55 -5.93 -0.31 7.56e-9 Moyamoya disease; CRC cis rs989128 0.600 rs8082568 chr17:48629312 G/C cg24438145 chr17:48624694 SPATA20 0.43 6.28 0.33 1.09e-9 Type 2 diabetes; CRC cis rs875971 0.825 rs801202 chr7:66023929 C/T cg00343986 chr7:65444356 GUSB -0.45 -6.23 -0.33 1.39e-9 Aortic root size; CRC trans rs61931739 0.517 rs1197562 chr12:34122037 G/A cg26384229 chr12:38710491 ALG10B 0.5 7.09 0.36 8.16e-12 Morning vs. evening chronotype; CRC cis rs8014204 0.816 rs4903262 chr14:75340818 A/G cg08847533 chr14:75593920 NEK9 0.4 5.79 0.3 1.6e-8 Caffeine consumption; CRC cis rs6952808 0.689 rs2008263 chr7:2048335 A/G cg18279126 chr7:2041391 MAD1L1 0.44 6.76 0.35 6.12e-11 Bipolar disorder and schizophrenia; CRC cis rs1003719 0.680 rs2835630 chr21:38521842 A/G cg10648535 chr21:38446584 PIGP;TTC3 -0.49 -6.89 -0.36 2.87e-11 Eye color traits; CRC cis rs1707322 1.000 rs1707337 chr1:46508769 A/G cg06784218 chr1:46089804 CCDC17 -0.55 -9.74 -0.47 7.43e-20 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC trans rs61931739 0.500 rs11053211 chr12:34464334 T/C cg13010199 chr12:38710504 ALG10B 0.46 6.52 0.34 2.65e-10 Morning vs. evening chronotype; CRC cis rs72781680 0.821 rs1022346 chr2:24127849 T/C cg08917208 chr2:24149416 ATAD2B 0.55 6.73 0.35 7.73e-11 Lymphocyte counts; CRC cis rs2439831 0.850 rs3742982 chr15:44176681 T/C cg02155558 chr15:43621948 ADAL;LCMT2 0.68 7.23 0.37 3.49e-12 Lung cancer in ever smokers; CRC cis rs72615157 0.645 rs76281814 chr7:99846414 T/C cg13153964 chr7:100026424 MEPCE;ZCWPW1 0.83 9.5 0.46 4.66e-19 Lung function (FEV1/FVC); CRC cis rs11764590 0.715 rs11766468 chr7:2082604 G/A cg23422044 chr7:1970798 MAD1L1 -0.5 -5.89 -0.31 9.8e-9 Neuroticism; CRC cis rs1865760 0.534 rs1541988 chr6:25950804 C/A cg17691542 chr6:26056736 HIST1H1C 0.42 6.54 0.34 2.42e-10 Height; CRC cis rs6952808 1.000 rs59248873 chr7:1888185 A/G cg22963979 chr7:1858916 MAD1L1 -0.59 -9.17 -0.45 5.3e-18 Bipolar disorder and schizophrenia; CRC cis rs853679 0.546 rs200995 chr6:27813694 C/T cg26587870 chr6:27730563 NA 0.67 6.81 0.35 4.76e-11 Depression; CRC cis rs6543140 0.964 rs10169192 chr2:103072211 A/G cg04239558 chr2:103089729 SLC9A4 0.37 6.58 0.34 1.83e-10 Blood protein levels; CRC cis rs67311347 1.000 rs6801859 chr3:40493218 G/T cg24209194 chr3:40518798 ZNF619 -0.4 -6.22 -0.32 1.49e-9 Renal cell carcinoma; CRC cis rs7680126 0.596 rs714436 chr4:10314667 A/C cg11266682 chr4:10021025 SLC2A9 -0.43 -6.4 -0.33 5.26e-10 Urate levels in lean individuals;Urate levels in overweight individuals;Urate levels in obese individuals; CRC cis rs883565 0.582 rs7623343 chr3:39146792 A/C cg01426195 chr3:39028469 NA -0.47 -7.79 -0.39 8.7e-14 Handedness; CRC cis rs6502050 0.835 rs7208673 chr17:80165908 G/C cg19223190 chr17:80058835 NA 0.41 6.67 0.35 1.09e-10 Life satisfaction; CRC cis rs1610096 0.538 rs2279796 chr19:1059004 A/G cg26576206 chr19:1064938 ABCA7 0.38 5.75 0.3 2.05e-8 Neutrophil percentage of granulocytes; CRC trans rs208520 1.000 rs12191598 chr6:66983962 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.88 10.79 0.51 1.94e-23 Exhaled nitric oxide output; CRC cis rs6663390 0.831 rs11118880 chr1:208085583 T/A cg03990033 chr1:208084030 CD34 0.49 6.5 0.34 2.97e-10 Facial morphology (factor 18); CRC cis rs12545109 0.800 rs2670054 chr8:57421616 C/T cg09654669 chr8:57350985 NA -0.45 -7.22 -0.37 3.74e-12 Obesity-related traits; CRC cis rs727505 0.954 rs59379598 chr7:124596903 C/G cg23710748 chr7:124431027 NA -0.81 -14.19 -0.62 5.26e-36 Lewy body disease; CRC cis rs6484504 0.625 rs6484501 chr11:31373100 G/T cg14844989 chr11:31128820 NA 0.35 6.07 0.32 3.58e-9 Red blood cell count; CRC cis rs13191362 0.810 rs66921603 chr6:162996982 G/A cg21926612 chr6:163149169 PACRG;PARK2 0.8 11.25 0.53 4.59e-25 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs8067545 0.641 rs1479129 chr17:19845769 A/G cg04132472 chr17:19861366 AKAP10 0.45 7.11 0.37 7.11e-12 Schizophrenia; CRC cis rs10267417 0.514 rs2072184 chr7:19748883 A/G cg07541023 chr7:19748670 TWISTNB 1.1 13.46 0.6 3.4e-33 Night sleep phenotypes; CRC cis rs637571 0.528 rs11602769 chr11:65594139 T/C cg04055107 chr11:65626734 MUS81;CFL1 -0.43 -5.98 -0.31 5.88e-9 Eosinophil percentage of white cells; CRC cis rs6860806 0.507 rs635619 chr5:131720265 G/A cg11843238 chr5:131593191 PDLIM4 -0.44 -7.39 -0.38 1.26e-12 Breast cancer; CRC cis rs344364 0.511 rs1657133 chr16:1950300 A/G cg00046913 chr16:1877150 HAGH;FAHD1 -0.58 -6.06 -0.32 3.66e-9 Glomerular filtration rate in chronic kidney disease; CRC cis rs798554 0.757 rs2533878 chr7:2878707 A/G cg17321639 chr7:2759063 NA 0.53 7.05 0.36 1.06e-11 Height; CRC cis rs6694672 0.764 rs4342879 chr1:197131655 T/C cg13682187 chr1:196946512 CFHR5 0.46 7.26 0.37 2.85e-12 Asthma; CRC trans rs1005277 0.540 rs1987431 chr10:37988887 T/C cg27523141 chr10:43048294 ZNF37B 0.44 6.32 0.33 8.44e-10 Extrinsic epigenetic age acceleration; CRC cis rs9487051 0.735 rs1146246 chr6:109519741 C/T cg21918786 chr6:109611834 NA -0.35 -6.05 -0.32 3.9e-9 Reticulocyte fraction of red cells; CRC cis rs13064411 0.660 rs1872747 chr3:113175785 T/A cg10517650 chr3:113235015 CCDC52 -0.37 -5.78 -0.3 1.76e-8 Response to simvastatin treatment (PCSK9 protein level change); CRC cis rs9486719 0.895 rs12527021 chr6:97025496 C/T cg06623918 chr6:96969491 KIAA0776 -0.82 -9.53 -0.47 3.58e-19 Migraine;Coronary artery disease; CRC cis rs9435341 0.965 rs9435441 chr1:107603330 C/G cg14828511 chr1:107599125 PRMT6 -0.5 -7.35 -0.38 1.54e-12 Facial morphology (factor 21, depth of nasal alae); CRC cis rs78456975 1.000 rs6708604 chr2:1556887 C/T cg01028140 chr2:1542097 TPO -0.57 -5.86 -0.31 1.11e-8 Placebo response in major depressive disorder (% change in symptom score); CRC cis rs7615952 0.512 rs4646765 chr3:125820707 G/A cg18479299 chr3:125709523 NA -0.55 -6.53 -0.34 2.45e-10 Blood pressure (smoking interaction); CRC cis rs6964587 1.000 rs2299232 chr7:91626699 A/C cg17063962 chr7:91808500 NA 0.76 12.34 0.56 5.39e-29 Breast cancer; CRC cis rs60843830 0.508 rs300750 chr2:208794 T/G cg25945732 chr2:264204 ACP1;SH3YL1 0.51 7.81 0.4 7.5e-14 Spherical equivalent (joint analysis main effects and education interaction); CRC cis rs12479064 0.671 rs4851207 chr2:100105775 G/T cg14399236 chr2:99771627 LIPT1;TSGA10 -0.61 -7.26 -0.37 2.75e-12 Chronic sinus infection; CRC cis rs2932538 0.961 rs4839257 chr1:113219388 A/T cg22162597 chr1:113214053 CAPZA1 -0.57 -8.37 -0.42 1.63e-15 Systolic blood pressure;Diastolic blood pressure;Hypertension;Blood pressure; CRC cis rs28374715 0.783 rs11630656 chr15:41570909 T/G cg18705301 chr15:41695430 NDUFAF1 -1.12 -17.53 -0.7 4.55e-49 Ulcerative colitis; CRC cis rs1519814 0.696 rs6985424 chr8:121062976 C/T cg22335954 chr8:121166405 COL14A1 -0.61 -6.53 -0.34 2.51e-10 Breast cancer; CRC cis rs7586879 0.929 rs6545808 chr2:25124388 C/A cg22495460 chr2:25135724 ADCY3 -0.72 -11.83 -0.55 3.81e-27 Body mass index; CRC cis rs6921919 0.638 rs6456815 chr6:28306137 C/A cg15845792 chr6:28175446 NA 0.49 6.55 0.34 2.19e-10 Autism spectrum disorder or schizophrenia; CRC trans rs3774749 0.565 rs1005678 chr3:50210289 C/G cg21659725 chr3:3221576 CRBN 0.44 6.55 0.34 2.23e-10 Intelligence (multi-trait analysis); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg15229027 chr14:64805542 ESR2 0.41 6.25 0.33 1.24e-9 Intelligence (multi-trait analysis); CRC cis rs3823572 0.542 rs62470446 chr7:133631002 C/T cg03336402 chr7:133662267 EXOC4 0.68 10.42 0.5 3.79e-22 Intelligence (multi-trait analysis); CRC cis rs3858526 0.959 rs61876224 chr11:5952859 G/A cg26762873 chr11:5879799 OR52E8 -0.4 -5.89 -0.31 9.6e-9 DNA methylation (variation); CRC cis rs9527 0.569 rs10883801 chr10:104677887 A/C cg15744005 chr10:104629667 AS3MT -0.31 -6.15 -0.32 2.29e-9 Arsenic metabolism; CRC cis rs7666738 0.830 rs7691864 chr4:98971376 G/C cg05340658 chr4:99064831 C4orf37 0.57 8.76 0.43 1.05e-16 Colonoscopy-negative controls vs population controls; CRC cis rs9837602 1.000 rs4075038 chr3:99680086 A/G cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G -0.47 -5.69 -0.3 2.81e-8 Breast cancer; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg14751398 chr6:20402153 E2F3 0.46 6.56 0.34 2.05e-10 Response to antipsychotic treatment; CRC cis rs3087591 0.708 rs2854319 chr17:29694054 G/C cg24425628 chr17:29625626 OMG;NF1 0.72 12.89 0.58 4.56e-31 Hip circumference; CRC cis rs10504229 1.000 rs73607874 chr8:58173433 G/C cg22535103 chr8:58192502 C8orf71 -0.82 -12.27 -0.56 9.63e-29 Developmental language disorder (linguistic errors); CRC cis rs7095944 0.613 rs11245366 chr10:126482849 C/T cg08799069 chr10:126477246 METTL10 -0.44 -6.97 -0.36 1.77e-11 Asthma; CRC cis rs28386778 0.897 rs8066754 chr17:61816590 T/C cg23090583 chr17:61904693 PSMC5;FTSJ3 1.03 19.94 0.74 1.46e-58 Prudent dietary pattern; CRC trans rs7395662 1.000 rs7481308 chr11:48600067 T/A cg21153622 chr11:89784906 NA -0.45 -7.27 -0.37 2.58e-12 HDL cholesterol; CRC cis rs853679 0.517 rs35512245 chr6:28079953 T/C cg25164649 chr6:28176230 NA 0.77 9.45 0.46 6.39e-19 Depression; CRC cis rs2228479 1.000 rs2228479 chr16:89985940 G/A cg19635926 chr16:89946313 TCF25 0.62 6.0 0.31 5.19e-9 Skin colour saturation; CRC cis rs2276314 1.000 rs4573997 chr18:33552568 C/T cg19628046 chr18:33552617 C18orf21 0.54 7.32 0.37 1.97e-12 Endometriosis;Drug-induced torsades de pointes; CRC cis rs300703 0.719 rs385909 chr2:199678 A/G cg21211680 chr2:198530 NA 0.89 10.96 0.52 5.04e-24 Blood protein levels; CRC cis rs7208859 0.623 rs73271842 chr17:29137155 T/C cg13385521 chr17:29058706 SUZ12P 0.74 8.44 0.42 9.97e-16 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs11190604 1.000 rs11190555 chr10:102209160 A/G cg07080220 chr10:102295463 HIF1AN 0.47 5.79 0.3 1.63e-8 Palmitoleic acid (16:1n-7) levels; CRC cis rs231513 0.769 rs537169 chr17:41976740 G/A cg26893861 chr17:41843967 DUSP3 -0.63 -6.36 -0.33 6.63e-10 Cognitive function; CRC cis rs877282 0.733 rs11253342 chr10:765072 A/G cg06581033 chr10:766294 NA -0.53 -5.88 -0.31 1.01e-8 Uric acid levels; CRC cis rs9747201 0.894 rs4503854 chr17:80178696 A/T cg09264619 chr17:80180166 NA -0.49 -6.86 -0.35 3.45e-11 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs7408868 0.908 rs10416777 chr19:15276923 C/T cg14696996 chr19:15285081 NOTCH3 0.96 9.0 0.44 1.82e-17 Pulse pressure; CRC cis rs1878931 0.580 rs8062722 chr16:3409161 G/A cg26668626 chr16:3451006 ZNF174;ZNF434 0.81 12.86 0.58 6.3e-31 Body mass index (adult); CRC cis rs9858542 1.000 rs9858542 chr3:49701983 A/G cg07274523 chr3:49395745 GPX1 -0.46 -6.04 -0.32 4.16e-9 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs28386778 0.863 rs3760256 chr17:61821161 A/G cg07362569 chr17:61921086 SMARCD2 0.37 5.71 0.3 2.58e-8 Prudent dietary pattern; CRC cis rs11585357 0.501 rs58620951 chr1:17573965 G/A cg08277548 chr1:17600880 PADI3 -0.67 -7.81 -0.4 7.6e-14 Hair shape; CRC cis rs12711979 0.765 rs10208316 chr2:3827630 T/C cg17052675 chr2:3827356 NA -0.59 -11.05 -0.52 2.35e-24 Itch intensity from mosquito bite adjusted by bite size; CRC cis rs4919694 1.000 rs12252500 chr10:104794984 G/C cg04362960 chr10:104952993 NT5C2 1.17 10.78 0.51 2.08e-23 Arsenic metabolism; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg01869960 chr2:136289456 R3HDM1;ZRANB3 0.47 6.76 0.35 6.32e-11 Intelligence (multi-trait analysis); CRC cis rs2576037 0.526 rs4890703 chr18:44522037 A/G cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.5 7.73 0.39 1.3e-13 Personality dimensions; CRC trans rs11825064 0.666 rs2156704 chr11:134485021 T/C cg00033773 chr19:12779366 MORG1;C19orf56 0.44 6.15 0.32 2.29e-9 Seasonality; CRC cis rs2839186 0.559 rs2277826 chr21:47639492 C/G cg11766577 chr21:47581405 C21orf56 0.38 5.82 0.31 1.4e-8 Testicular germ cell tumor; CRC cis rs897984 0.760 rs11076 chr16:30995528 A/G cg02466173 chr16:30829666 NA 0.63 9.43 0.46 7.37e-19 Dementia with Lewy bodies; CRC cis rs427943 0.712 rs983749 chr21:46601851 A/G cg19498844 chr21:46707878 POFUT2;LOC642852 0.45 5.99 0.31 5.5e-9 Body mass index; CRC cis rs262150 0.851 rs2527224 chr7:158769198 G/A cg10570241 chr7:158785291 NA 0.52 9.41 0.46 8.87e-19 Facial morphology (factor 20); CRC trans rs13315871 0.615 rs6793358 chr3:58356454 C/G cg25250853 chr2:85822726 RNF181 0.52 6.21 0.32 1.6e-9 Cholesterol, total; CRC cis rs2731664 0.740 rs2731670 chr5:176848019 G/T cg23176889 chr5:176863531 GRK6 0.68 14.1 0.61 1.25e-35 Intelligence (multi-trait analysis); CRC trans rs8141529 0.507 rs5762936 chr22:29381377 A/G cg20356147 chr3:127914850 EEFSEC -0.53 -6.54 -0.34 2.4e-10 Lymphocyte counts; CRC cis rs10504229 1.000 rs76023408 chr8:58193345 A/G cg05313129 chr8:58192883 C8orf71 -0.47 -6.97 -0.36 1.77e-11 Developmental language disorder (linguistic errors); CRC cis rs1005277 0.579 rs1780115 chr10:38524773 C/T cg25517755 chr10:38738941 LOC399744 -0.41 -5.92 -0.31 8.23e-9 Extrinsic epigenetic age acceleration; CRC cis rs4713118 0.513 rs149975 chr6:27986340 G/A cg12172441 chr6:28176163 NA 0.54 7.51 0.38 5.63e-13 Parkinson's disease; CRC cis rs6674176 0.628 rs3791119 chr1:44431362 C/G cg15962314 chr1:44399869 ARTN 0.3 5.76 0.3 1.94e-8 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Cognitive ability; CRC cis rs8072100 0.967 rs11656855 chr17:45714655 C/T cg25173405 chr17:45401733 C17orf57 0.43 6.6 0.34 1.61e-10 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC trans rs7623430 1.000 rs1450004 chr3:36192176 G/A cg16587794 chr15:69706675 KIF23 0.41 6.01 0.31 4.88e-9 Response to abacavir-containing treatment in HIV-1 infection (virologic failure); CRC cis rs7586879 0.521 rs1865689 chr2:25108197 C/T cg22495460 chr2:25135724 ADCY3 0.87 17.27 0.69 5.11e-48 Body mass index; CRC cis rs921968 0.541 rs3770216 chr2:219443717 A/G cg02176678 chr2:219576539 TTLL4 -0.58 -9.18 -0.45 4.86e-18 Mean corpuscular hemoglobin concentration; CRC trans rs3942852 0.955 rs1503190 chr11:48117873 A/G cg03929089 chr4:120376271 NA -0.52 -6.41 -0.33 5.04e-10 Acute lymphoblastic leukemia (childhood); CRC cis rs12477438 0.501 rs11123770 chr2:99825102 A/G cg14399236 chr2:99771627 LIPT1;TSGA10 0.63 10.1 0.49 4.39e-21 Chronic sinus infection; CRC cis rs11645898 0.935 rs72787077 chr16:72156674 C/T cg14768367 chr16:72042858 DHODH -0.59 -6.68 -0.35 1.03e-10 Blood protein levels; CRC cis rs10486722 0.651 rs6975680 chr7:41803450 A/G cg22138096 chr7:41772439 LOC285954 0.63 7.72 0.39 1.38e-13 Pit-and-Fissure caries; CRC trans rs925098 0.577 rs2724470 chr4:17996046 A/G cg11809157 chr19:47734715 BBC3 -0.44 -6.06 -0.32 3.68e-9 Birth weight;Height; CRC cis rs12760731 0.623 rs3791025 chr1:178357907 C/G cg00404053 chr1:178313656 RASAL2 0.72 8.99 0.44 1.94e-17 Obesity-related traits; CRC cis rs12541635 0.677 rs7003520 chr8:107061724 G/A cg10147462 chr8:107024639 NA 0.61 10.58 0.5 1.02e-22 Age of smoking initiation; CRC cis rs9322193 0.962 rs9689447 chr6:150110486 T/A cg13206674 chr6:150067644 NUP43 0.57 8.14 0.41 8.29e-15 Lung cancer; CRC cis rs9303542 0.559 rs35621842 chr17:46606222 C/T cg04904318 chr17:46607828 HOXB1 -0.56 -6.54 -0.34 2.28e-10 Ovarian cancer;Epithelial ovarian cancer; CRC cis rs7493 1.000 rs6968305 chr7:95042529 G/A cg04871131 chr7:94954202 PON1 -0.46 -5.64 -0.3 3.63e-8 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs4713118 0.619 rs200486 chr6:27779506 C/T cg06470822 chr6:28175283 NA 0.63 6.95 0.36 2e-11 Parkinson's disease; CRC cis rs11148252 0.846 rs13431 chr13:52987477 G/C cg00495681 chr13:53174319 NA 0.57 8.54 0.43 4.9e-16 Lewy body disease; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg11200644 chr18:72265018 LOC400657 0.45 6.47 0.34 3.52e-10 Response to antipsychotic treatment; CRC cis rs7552404 1.000 rs1498315 chr1:76159225 G/A cg03433033 chr1:76189801 ACADM 0.82 11.35 0.53 1.98e-25 Blood metabolite levels;Acylcarnitine levels; CRC cis rs1915146 0.967 rs7086481 chr10:126844523 A/T cg05090351 chr10:126851162 NA -0.61 -9.44 -0.46 7.18e-19 Menarche (age at onset); CRC cis rs977987 0.806 rs8057203 chr16:75404974 T/C cg03315344 chr16:75512273 CHST6 0.54 9.11 0.45 8.36e-18 Dupuytren's disease; CRC cis rs2075371 0.796 rs1646644 chr7:134011817 A/T cg11752832 chr7:134001865 SLC35B4 0.47 7.1 0.36 7.81e-12 Mean platelet volume; CRC cis rs78545713 0.502 rs3823157 chr6:26272039 A/G cg08578491 chr6:26276143 NA 0.48 6.6 0.34 1.65e-10 Iron status biomarkers (total iron binding capacity); CRC cis rs1538970 0.962 rs2153609 chr1:45814058 A/G cg05343316 chr1:45956843 TESK2 0.65 8.91 0.44 3.5e-17 Platelet count; CRC cis rs4972806 0.849 rs2857541 chr2:177029086 C/T cg25347419 chr2:177043501 NA 0.59 9.18 0.45 5.04e-18 IgG glycosylation; CRC cis rs11628318 0.614 rs7155883 chr14:103123404 A/C cg12046867 chr14:103022105 NA 0.76 9.03 0.45 1.44e-17 Platelet count; CRC cis rs2806561 0.765 rs623988 chr1:23519477 C/T cg12483005 chr1:23474871 LUZP1 0.49 7.15 0.37 5.58e-12 Height; CRC trans rs2403907 0.758 rs2823134 chr21:16569063 A/G cg00407105 chr4:90231041 NA -0.4 -6.13 -0.32 2.52e-9 Breast cancer; CRC cis rs1448094 0.791 rs61929394 chr12:86331541 C/A cg00310523 chr12:86230176 RASSF9 0.43 7.28 0.37 2.42e-12 Major depressive disorder; CRC cis rs9814567 1.000 rs12490835 chr3:134223730 T/C cg06109529 chr3:134205091 CEP63;ANAPC13 -0.81 -12.37 -0.56 4.1e-29 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs6598955 0.612 rs12738188 chr1:26548029 G/C cg00852783 chr1:26633632 UBXN11 0.44 7.12 0.37 6.79e-12 Obesity-related traits; CRC cis rs853679 0.517 rs2273564 chr6:28057594 A/T cg23161317 chr6:28129485 ZNF389 0.52 6.35 0.33 6.97e-10 Depression; CRC cis rs13064411 0.696 rs6799610 chr3:113248748 A/C cg18753928 chr3:113234510 CCDC52 0.68 10.37 0.5 5.5e-22 Response to simvastatin treatment (PCSK9 protein level change); CRC cis rs7647973 0.626 rs9830730 chr3:49675875 G/C cg13072238 chr3:49761600 GMPPB -0.52 -6.04 -0.32 4.14e-9 Menarche (age at onset); CRC cis rs8180040 0.966 rs9683033 chr3:47489820 C/T cg02527881 chr3:46936655 PTH1R -0.41 -7.82 -0.4 7.16e-14 Colorectal cancer; CRC trans rs7824557 0.505 rs2736313 chr8:11086942 C/T cg16141378 chr3:129829833 LOC729375 -0.46 -6.85 -0.35 3.67e-11 Retinal vascular caliber; CRC cis rs3857067 1.000 rs2865330 chr4:95004716 A/G cg11021082 chr4:95130006 SMARCAD1 -0.4 -6.04 -0.32 4.06e-9 QT interval; CRC cis rs9858542 1.000 rs9823546 chr3:49705512 T/A cg00383909 chr3:49044727 WDR6 0.46 5.77 0.3 1.84e-8 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs4319547 0.956 rs7316149 chr12:123063912 G/A cg23029597 chr12:123009494 RSRC2 -0.62 -7.92 -0.4 3.73e-14 Body mass index; CRC cis rs6951245 1.000 rs76129108 chr7:1089159 G/A cg03188948 chr7:1209495 NA 0.64 6.46 0.34 3.71e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs4555082 0.645 rs2816605 chr14:105715515 C/T cg10792982 chr14:105748885 BRF1 0.35 5.66 0.3 3.23e-8 Mean platelet volume;Platelet distribution width; CRC cis rs4076764 0.914 rs10753614 chr1:163365903 C/T cg06092702 chr1:163392909 NA 0.53 8.54 0.43 5.16e-16 Motion sickness; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg25998860 chr5:126853954 PRRC1 0.47 6.12 0.32 2.66e-9 Thyroid stimulating hormone; CRC cis rs1867631 0.585 rs5008753 chr1:67092248 A/G cg02459107 chr1:67143332 SGIP1 0.33 5.9 0.31 9.17e-9 Menopause (age at onset); CRC trans rs7615952 0.599 rs2279821 chr3:125734308 G/A cg07211511 chr3:129823064 LOC729375 -0.77 -10.26 -0.49 1.33e-21 Blood pressure (smoking interaction); CRC cis rs60843830 0.623 rs55932737 chr2:107543 C/T cg00108164 chr2:264199 ACP1;SH3YL1 0.41 5.79 0.3 1.62e-8 Spherical equivalent (joint analysis main effects and education interaction); CRC cis rs3818285 0.632 rs536343 chr10:111632879 T/C cg00817464 chr10:111662876 XPNPEP1 0.64 11.21 0.53 6.37e-25 Superior crus of antihelix expression; CRC cis rs5769765 0.542 rs5769751 chr22:50242733 T/G cg02269571 chr22:50332266 NA 1.29 12.5 0.57 1.36e-29 Schizophrenia; CRC cis rs514406 0.679 rs545719 chr1:53304922 T/C cg08859206 chr1:53392774 SCP2 -0.59 -9.45 -0.46 6.6e-19 Monocyte count; CRC trans rs208515 0.525 rs12215007 chr6:66671008 C/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.94 -12.06 -0.55 5.62e-28 Exhaled nitric oxide levels; CRC cis rs6089584 0.606 rs2273989 chr20:60579138 G/A cg23262073 chr20:60523788 NA -0.38 -6.28 -0.33 1.07e-9 Body mass index; CRC cis rs12477438 0.765 rs2309521 chr2:99592069 C/T cg14399236 chr2:99771627 LIPT1;TSGA10 -0.6 -8.21 -0.41 5.18e-15 Chronic sinus infection; CRC cis rs863345 0.604 rs2157687 chr1:158493000 C/T cg12129480 chr1:158549410 OR10X1 -0.29 -5.95 -0.31 7e-9 Pneumococcal bacteremia; CRC cis rs6951245 1.000 rs78185801 chr7:1096367 G/A cg20603222 chr7:1096387 C7orf50;GPR146 -0.72 -8.67 -0.43 1.96e-16 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs921968 0.565 rs6436071 chr2:219598041 A/T cg02176678 chr2:219576539 TTLL4 -0.39 -6.27 -0.33 1.12e-9 Mean corpuscular hemoglobin concentration; CRC cis rs10878977 0.542 rs60878854 chr12:69815236 G/A cg20891283 chr12:69753455 YEATS4 -0.6 -5.92 -0.31 8.13e-9 Colorectal cancer; CRC cis rs1005277 0.579 rs1614236 chr10:38502996 C/T cg25427524 chr10:38739819 LOC399744 -0.77 -13.58 -0.6 1.19e-33 Extrinsic epigenetic age acceleration; CRC cis rs35306767 0.855 rs34318754 chr10:890714 G/A cg20503657 chr10:835505 NA 1.23 14.72 0.63 4.77e-38 Eosinophil percentage of granulocytes; CRC cis rs9611565 0.659 rs73178626 chr22:41928371 T/G cg03806693 chr22:41940476 POLR3H -1.12 -15.0 -0.64 3.94e-39 Vitiligo; CRC cis rs7085104 0.552 rs11191414 chr10:104601565 A/T cg04362960 chr10:104952993 NT5C2 0.6 8.71 0.43 1.51e-16 Immature fraction of reticulocytes;Schizophrenia; CRC trans rs11098499 0.775 rs10021601 chr4:120282563 G/A cg25214090 chr10:38739885 LOC399744 0.61 9.66 0.47 1.29e-19 Corneal astigmatism; CRC cis rs6502050 0.765 rs6502075 chr17:80121813 G/A cg02741985 chr17:80059408 CCDC57 0.43 7.15 0.37 5.6e-12 Life satisfaction; CRC cis rs6582630 0.502 rs11514371 chr12:38306306 G/C cg26384229 chr12:38710491 ALG10B 0.69 9.74 0.47 7.18e-20 Drug-induced liver injury (flucloxacillin); CRC cis rs17767392 0.834 rs11626886 chr14:71727155 C/T cg13720639 chr14:72061746 SIPA1L1 -0.52 -6.2 -0.32 1.74e-9 Mitral valve prolapse; CRC trans rs1455244 0.700 rs7229302 chr18:11508904 G/T cg16204370 chr22:41682343 RANGAP1 0.44 6.83 0.35 4.17e-11 Schizophrenia; CRC cis rs28655083 0.957 rs7185514 chr16:77070129 T/G cg01753188 chr16:77233325 SYCE1L;MON1B -0.59 -8.4 -0.42 1.33e-15 Lobe attachment (rater-scored or self-reported); CRC cis rs9648716 1.000 rs10281508 chr7:140565218 T/C cg10747023 chr7:140774559 NA 0.43 5.64 0.3 3.61e-8 Type 2 diabetes; CRC cis rs644799 0.544 rs498553 chr11:95534441 G/A cg03916912 chr11:95522834 CEP57;FAM76B 0.7 11.59 0.54 2.81e-26 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs7568458 0.709 rs11895401 chr2:85753847 C/T cg02493740 chr2:85810744 VAMP5 -0.5 -7.57 -0.39 3.84e-13 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); CRC cis rs4731207 0.724 rs10257255 chr7:124479678 C/T cg23710748 chr7:124431027 NA 0.38 6.08 0.32 3.28e-9 Cutaneous malignant melanoma; CRC cis rs3126085 0.935 rs4845750 chr1:152201217 A/G cg09127314 chr1:152161683 NA 0.46 5.69 0.3 2.77e-8 Atopic dermatitis; CRC cis rs9660992 0.539 rs113699533 chr1:205122895 G/A cg03948781 chr1:205179583 DSTYK 0.42 5.85 0.31 1.2e-8 Mean corpuscular volume;Mean platelet volume; CRC cis rs2228479 0.557 rs12933317 chr16:89828220 A/G cg06558623 chr16:89946397 TCF25 1.13 10.46 0.5 2.64e-22 Skin colour saturation; CRC cis rs875971 0.895 rs10755833 chr7:65913917 A/G cg11764359 chr7:65958608 NA 0.62 9.91 0.48 1.96e-20 Aortic root size; CRC cis rs4713118 0.869 rs6922574 chr6:27693003 A/T cg12273811 chr6:28175739 NA 0.55 7.7 0.39 1.56e-13 Parkinson's disease; CRC cis rs6964587 1.000 rs6974607 chr7:91750116 G/A cg17063962 chr7:91808500 NA 0.78 12.5 0.57 1.32e-29 Breast cancer; CRC cis rs6701037 0.566 rs13373754 chr1:175139275 C/A cg14847009 chr1:175162515 KIAA0040 0.31 6.97 0.36 1.72e-11 Alcohol dependence; CRC cis rs4713118 0.662 rs9468275 chr6:28026136 G/T cg25164649 chr6:28176230 NA 0.65 8.57 0.43 4.18e-16 Parkinson's disease; CRC cis rs12477438 1.000 rs995617 chr2:99857904 G/T cg14399236 chr2:99771627 LIPT1;TSGA10 0.69 8.34 0.42 2.01e-15 Chronic sinus infection; CRC cis rs1005277 0.579 rs1548255 chr10:38417193 T/C cg25427524 chr10:38739819 LOC399744 -0.77 -13.57 -0.6 1.3e-33 Extrinsic epigenetic age acceleration; CRC cis rs6545883 0.929 rs2421203 chr2:61669248 C/A cg15711740 chr2:61764176 XPO1 -0.47 -6.16 -0.32 2.16e-9 Tuberculosis; CRC trans rs61931739 0.500 rs11053194 chr12:34440841 A/G cg13010199 chr12:38710504 ALG10B 0.46 6.52 0.34 2.6e-10 Morning vs. evening chronotype; CRC cis rs2304069 0.779 rs245081 chr5:149356075 G/T cg22760475 chr5:149380129 HMGXB3;TIGD6 0.5 6.23 0.32 1.46e-9 HIV-1 control; CRC cis rs9911578 1.000 rs7342903 chr17:56914588 C/G cg05425664 chr17:57184151 TRIM37 -0.49 -7.72 -0.39 1.45e-13 Intelligence (multi-trait analysis); CRC cis rs35306767 0.761 rs11253558 chr10:1043983 T/C cg20503657 chr10:835505 NA 0.92 11.13 0.52 1.19e-24 Eosinophil percentage of granulocytes; CRC cis rs2735413 0.918 rs12598024 chr16:78079114 G/A cg04733911 chr16:78082701 NA -0.45 -7.5 -0.38 6.09e-13 Systolic blood pressure (alcohol consumption interaction); CRC cis rs10504229 0.953 rs115634610 chr8:58190533 G/A cg24829409 chr8:58192753 C8orf71 -0.68 -11.29 -0.53 3.23e-25 Developmental language disorder (linguistic errors); CRC cis rs4561483 0.583 rs11075027 chr16:11948895 T/C cg08843971 chr16:11963173 GSPT1 0.52 7.72 0.39 1.38e-13 Testicular germ cell tumor; CRC cis rs17095355 1.000 rs17126902 chr10:111710381 A/G cg00817464 chr10:111662876 XPNPEP1 0.64 7.81 0.4 7.98e-14 Biliary atresia; CRC cis rs10540 1.000 rs71487296 chr11:500282 G/A cg03576123 chr11:487126 PTDSS2 -1.04 -10.8 -0.51 1.77e-23 Body mass index; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg03571604 chr17:17875744 TOM1L2;LRRC48 0.41 6.68 0.35 1e-10 Liver disease severity in Alagille syndrome; CRC cis rs7945705 0.782 rs3763918 chr11:8819683 T/A cg14711859 chr11:8959438 ASCL3 -0.37 -5.89 -0.31 9.53e-9 Hemoglobin concentration; CRC cis rs4862307 0.688 rs6552743 chr4:184990516 C/G cg06737308 chr4:185021514 ENPP6 0.37 5.68 0.3 2.89e-8 Serum dimethylarginine levels (asymmetric/symetric ratio); CRC trans rs724568 0.681 rs1978656 chr2:67920009 A/G cg15815156 chr15:52472201 GNB5 -0.41 -6.29 -0.33 1.01e-9 Major depressive disorder (broad); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg14843216 chr17:56064736 VEZF1 0.44 6.14 0.32 2.41e-9 Response to antipsychotic treatment; CRC cis rs7772486 0.743 rs9376955 chr6:145949404 T/A cg23711669 chr6:146136114 FBXO30 0.66 11.0 0.52 3.6e-24 Lobe attachment (rater-scored or self-reported); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg09732282 chr15:58474918 AQP9 0.45 7.01 0.36 1.39e-11 Response to antipsychotic treatment; CRC cis rs637571 0.565 rs633800 chr11:65638719 G/A cg26695010 chr11:65641043 EFEMP2 0.57 9.0 0.44 1.8e-17 Eosinophil percentage of white cells; CRC trans rs4263408 0.934 rs9683743 chr4:39703194 A/C cg12873262 chr11:134094364 NCAPD3;VPS26B -0.42 -6.05 -0.32 3.92e-9 Plasma amyloid beta peptide concentrations (ABx-40); CRC cis rs3749237 0.964 rs1799843 chr3:49849723 G/A cg03060546 chr3:49711283 APEH 0.42 6.3 0.33 9.44e-10 Resting heart rate; CRC cis rs7209700 0.632 rs11657963 chr17:45347533 G/A cg08085267 chr17:45401833 C17orf57 0.44 5.98 0.31 5.88e-9 IgG glycosylation; CRC cis rs4285028 0.747 rs7648343 chr3:121426195 G/A cg11130432 chr3:121712080 ILDR1 -0.51 -6.08 -0.32 3.28e-9 Multiple sclerosis; CRC cis rs2386661 0.603 rs11259704 chr10:5646999 C/T cg17085576 chr10:5658249 NA -0.41 -5.86 -0.31 1.11e-8 Breast cancer; CRC cis rs904251 0.772 rs756202 chr6:37460350 C/A cg01843034 chr6:37503916 NA -0.35 -5.81 -0.31 1.46e-8 Cognitive performance; CRC cis rs1784581 0.855 rs1893101 chr6:162384371 G/C cg17173639 chr6:162384350 PARK2 -0.84 -15.17 -0.64 9.22e-40 Itch intensity from mosquito bite; CRC cis rs28374715 0.662 rs11852419 chr15:41456374 A/T cg18705301 chr15:41695430 NDUFAF1 0.81 12.44 0.57 2.14e-29 Ulcerative colitis; CRC cis rs12580194 0.593 rs12579408 chr12:55764348 G/A cg23425280 chr12:56401806 NA 0.47 5.7 0.3 2.71e-8 Cancer; CRC cis rs1865760 0.928 rs9295673 chr6:25912094 T/G cg16482183 chr6:26056742 HIST1H1C 0.54 7.79 0.39 9.09e-14 Height; CRC cis rs6088813 1.000 rs6087698 chr20:33948919 A/G cg14752227 chr20:34000481 UQCC -0.37 -5.82 -0.31 1.37e-8 Height; CRC cis rs9914988 0.943 rs9893782 chr17:27108132 C/T cg16670446 chr17:27188758 MIR451;MIR144 0.55 8.52 0.43 5.75e-16 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs7945705 0.870 rs1109305 chr11:8955272 C/T cg21881798 chr11:8931708 C11orf17;ST5 0.67 10.28 0.49 1.13e-21 Hemoglobin concentration; CRC cis rs12760731 0.565 rs10913520 chr1:178200760 A/T cg00404053 chr1:178313656 RASAL2 1.05 10.89 0.51 8.62e-24 Obesity-related traits; CRC cis rs4824093 0.610 rs58888255 chr22:50315627 G/A cg22709217 chr22:50311962 ALG12;CRELD2 -0.95 -7.79 -0.39 9.01e-14 Amyotrophic lateral sclerosis (sporadic); CRC cis rs9556958 0.635 rs4529985 chr13:99167120 G/C cg07423050 chr13:99094983 FARP1 -0.42 -6.36 -0.33 6.67e-10 Educational attainment (years of education); CRC cis rs2228479 0.850 rs17227263 chr16:89810598 G/A cg06656553 chr16:89960601 TCF25 -0.68 -5.71 -0.3 2.55e-8 Skin colour saturation; CRC cis rs6696846 0.765 rs3738155 chr1:205074424 C/T cg00857998 chr1:205179979 DSTYK 0.46 6.37 0.33 6.44e-10 Red blood cell count; CRC cis rs7666738 0.830 rs10516426 chr4:99035827 A/G cg05340658 chr4:99064831 C4orf37 0.61 9.43 0.46 7.65e-19 Colonoscopy-negative controls vs population controls; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg02891801 chr12:6472782 SCNN1A 0.45 6.26 0.33 1.18e-9 Response to antipsychotic treatment; CRC cis rs4891159 0.790 rs9950025 chr18:74113596 C/G cg24786174 chr18:74118243 ZNF516 0.91 17.03 0.68 4.29e-47 Longevity; CRC cis rs270601 0.690 rs162907 chr5:131580152 A/G cg22638593 chr5:131593259 PDLIM4 -0.52 -9.27 -0.46 2.47e-18 Acylcarnitine levels; CRC cis rs13191362 0.810 rs66921603 chr6:162996982 G/A cg06582575 chr6:163149167 PACRG;PARK2 0.77 10.7 0.51 3.98e-23 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs7177699 0.550 rs7182103 chr15:79123946 G/T cg15571903 chr15:79123663 NA 0.34 6.91 0.36 2.55e-11 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; CRC cis rs7937682 1.000 rs7937682 chr11:111579939 C/G cg19812747 chr11:111475976 SIK2 -0.52 -8.35 -0.42 1.87e-15 Primary sclerosing cholangitis; CRC cis rs3812762 0.912 rs10769953 chr11:8778352 A/G cg00186954 chr11:8933980 ST5;C11orf17 0.37 6.02 0.32 4.62e-9 Hypospadias; CRC cis rs7605827 0.866 rs9287665 chr2:15667263 A/T cg19274914 chr2:15703543 NA 0.39 5.87 0.31 1.07e-8 Educational attainment (years of education); CRC cis rs3750965 0.920 rs10896420 chr11:68863047 G/A cg06818126 chr11:68850279 TPCN2 -0.47 -6.64 -0.34 1.26e-10 Hair color; CRC cis rs1799949 1.000 rs33994002 chr17:41328818 T/A cg01879757 chr17:41196368 BRCA1 -0.43 -6.62 -0.34 1.51e-10 Menopause (age at onset); CRC cis rs853679 0.517 rs1340004 chr6:28103691 C/T cg15845792 chr6:28175446 NA 1.03 14.0 0.61 3e-35 Depression; CRC cis rs11098499 0.866 rs6824111 chr4:120285968 T/A cg24375607 chr4:120327624 NA 0.48 7.48 0.38 6.72e-13 Corneal astigmatism; CRC cis rs7202877 0.706 rs1074961 chr16:75389484 C/T cg03315344 chr16:75512273 CHST6 0.48 5.82 0.31 1.4e-8 Type 2 diabetes;Type 1 diabetes; CRC cis rs9467773 0.620 rs2451741 chr6:26629404 A/G cg09904177 chr6:26538194 HMGN4 0.73 11.55 0.54 3.94e-26 Intelligence (multi-trait analysis); CRC cis rs282587 0.597 rs390177 chr13:113413033 A/G cg04656015 chr13:113407548 ATP11A 0.57 7.49 0.38 6.24e-13 Glycated hemoglobin levels; CRC cis rs877282 0.898 rs35743076 chr10:758991 C/T cg06581033 chr10:766294 NA -0.5 -5.74 -0.3 2.17e-8 Uric acid levels; CRC cis rs2456568 0.803 rs10765641 chr11:93640312 T/C cg26875233 chr11:93583750 C11orf90 -0.31 -6.05 -0.32 3.93e-9 Response to serotonin reuptake inhibitors in major depressive disorder; CRC cis rs10791323 0.517 rs1120245 chr11:133745290 A/G cg06766960 chr11:133703094 NA -0.32 -5.73 -0.3 2.24e-8 Childhood ear infection; CRC trans rs10982213 0.830 rs2274163 chr9:117188714 C/T cg23944232 chr2:86948118 RMND5A 0.37 5.99 0.31 5.5e-9 Interleukin-6 levels; CRC cis rs3785574 0.962 rs2597632 chr17:61894739 A/T cg25654072 chr17:61904446 PSMC5;FTSJ3 0.44 6.01 0.31 4.82e-9 Height; CRC cis rs68170813 0.559 rs59782202 chr7:107032766 G/T cg02696742 chr7:106810147 HBP1 -0.53 -5.9 -0.31 8.94e-9 Coronary artery disease; CRC cis rs13108904 0.870 rs4974542 chr4:1250908 A/G cg02018176 chr4:1364513 KIAA1530 0.45 7.56 0.38 4.03e-13 Obesity-related traits; CRC cis rs6502050 0.799 rs4789673 chr17:80123218 T/C cg25804541 chr17:80189381 SLC16A3 -0.31 -5.95 -0.31 6.84e-9 Life satisfaction; CRC trans rs629535 0.814 rs62513371 chr8:70077779 T/A cg21567404 chr3:27674614 NA -0.93 -15.12 -0.64 1.44e-39 Dupuytren's disease; CRC cis rs7208859 0.673 rs216409 chr17:28906269 C/T cg01831904 chr17:28903510 LRRC37B2 0.46 5.64 0.3 3.63e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs9309473 0.687 rs12465867 chr2:73612102 C/T cg20560298 chr2:73613845 ALMS1 -0.53 -7.53 -0.38 4.94e-13 Metabolite levels; CRC cis rs7726839 0.540 rs61731455 chr5:665295 A/G cg14541582 chr5:601475 NA -0.34 -6.46 -0.34 3.71e-10 Obesity-related traits; CRC cis rs1035144 0.510 rs12432357 chr14:81299468 A/G cg06600135 chr14:81408086 NA -0.48 -6.85 -0.35 3.53e-11 Male sexual orientation; CRC cis rs10911232 0.507 rs12037585 chr1:183000041 G/T ch.1.3577855R chr1:183094577 LAMC1 0.86 15.15 0.64 1.1e-39 Hypertriglyceridemia; CRC cis rs2153535 0.601 rs1855765 chr6:8444325 C/T cg07606381 chr6:8435919 SLC35B3 0.68 10.86 0.51 1.08e-23 Motion sickness; CRC cis rs10504229 0.813 rs6999878 chr8:58197243 C/G cg22535103 chr8:58192502 C8orf71 -0.56 -7.3 -0.37 2.21e-12 Developmental language disorder (linguistic errors); CRC cis rs9660180 0.839 rs12040826 chr1:1705287 A/C cg13866156 chr1:1669148 SLC35E2 -0.63 -9.74 -0.47 7.42e-20 Body mass index; CRC cis rs6951245 0.935 rs112554101 chr7:1065535 A/G cg18402987 chr7:1209562 NA 0.51 6.07 0.32 3.62e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC trans rs3807766 0.581 rs6954104 chr7:77693258 C/T cg05014952 chr14:35873130 NFKBIA -0.43 -6.06 -0.32 3.68e-9 3-hydroxypropylmercapturic acid levels in smokers; CRC cis rs1707322 0.717 rs1972410 chr1:46080947 G/T cg06784218 chr1:46089804 CCDC17 0.65 12.18 0.56 2.03e-28 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs1322512 1.000 rs2996635 chr6:153011163 C/T cg03415253 chr6:152958462 SYNE1 0.4 6.05 0.32 4.05e-9 Tonometry; CRC cis rs6500602 0.610 rs1659499 chr16:4595269 G/A cg14951292 chr16:4525986 HMOX2;NMRAL1 -0.56 -8.56 -0.43 4.28e-16 Schizophrenia; CRC cis rs826838 0.967 rs11183022 chr12:38652519 G/A cg26384229 chr12:38710491 ALG10B 0.72 10.21 0.49 1.87e-21 Heart rate; CRC cis rs4434138 0.664 rs62255364 chr3:52701502 C/T cg05573699 chr3:52720067 GNL3;PBRM1 -0.47 -6.65 -0.34 1.19e-10 Intelligence (multi-trait analysis); CRC cis rs7618915 0.547 rs1561337 chr3:52659963 C/T cg18404041 chr3:52824283 ITIH1 -0.42 -8.61 -0.43 3.11e-16 Bipolar disorder; CRC cis rs2204008 0.652 rs11513964 chr12:37998214 C/G cg26384229 chr12:38710491 ALG10B 0.68 8.93 0.44 3.1e-17 Bladder cancer; CRC cis rs4547160 0.781 rs12228037 chr12:63484560 C/T cg26727693 chr12:63544175 AVPR1A 0.41 7.63 0.39 2.54e-13 Morning vs. evening chronotype; CRC cis rs116095464 0.558 rs62347683 chr5:230331 C/T cg22496380 chr5:211416 CCDC127 -0.85 -9.81 -0.48 4.2e-20 Breast cancer; CRC cis rs6815814 0.861 rs1135430 chr4:38789361 T/C cg06935464 chr4:38784597 TLR10 0.65 8.22 0.41 4.87e-15 Breast cancer; CRC cis rs7618915 0.547 rs33967311 chr3:52683864 G/T cg08222913 chr3:52553049 STAB1 -0.33 -6.05 -0.32 3.92e-9 Bipolar disorder; CRC cis rs7647973 0.626 rs2131108 chr3:49665390 C/T cg13072238 chr3:49761600 GMPPB -0.52 -5.96 -0.31 6.51e-9 Menarche (age at onset); CRC cis rs637571 0.726 rs526631 chr11:65681965 T/G cg04055107 chr11:65626734 MUS81;CFL1 -0.41 -5.76 -0.3 1.94e-8 Eosinophil percentage of white cells; CRC cis rs12368653 0.591 rs1552842 chr12:58012163 A/G cg12615879 chr12:58013172 SLC26A10 -0.33 -5.99 -0.31 5.48e-9 Multiple sclerosis; CRC cis rs1538970 0.924 rs1007858 chr1:45912005 C/T cg05343316 chr1:45956843 TESK2 0.74 9.85 0.48 3.12e-20 Platelet count; CRC trans rs35094601 1.000 rs11679023 chr2:139225571 G/A cg25299176 chr17:1303341 YWHAE -0.47 -6.67 -0.35 1.1e-10 Schizophrenia; CRC cis rs4363385 0.747 rs1999886 chr1:152955522 T/C cg25856811 chr1:152973957 SPRR3 -0.27 -7.45 -0.38 8.09e-13 Inflammatory skin disease; CRC cis rs875971 0.528 rs801213 chr7:66014918 C/T cg03233332 chr7:66118400 NA 0.43 5.98 0.31 5.79e-9 Aortic root size; CRC cis rs929354 0.742 rs2051877 chr7:157008813 A/T cg05182265 chr7:156933206 UBE3C -0.76 -14.25 -0.62 3.15e-36 Body mass index; CRC cis rs62229266 0.625 rs62230813 chr21:37403432 C/T cg12218747 chr21:37451666 NA -0.36 -6.06 -0.32 3.74e-9 Mitral valve prolapse; CRC cis rs736801 0.808 rs2522057 chr5:131801947 C/G cg21138405 chr5:131827807 IRF1 -0.34 -5.75 -0.3 2.03e-8 Breast cancer;Mosquito bite size; CRC cis rs2439831 1.000 rs9920763 chr15:43760508 T/G cg15269541 chr15:43626905 ADAL -0.62 -6.48 -0.34 3.31e-10 Lung cancer in ever smokers; CRC cis rs2204008 0.744 rs11181337 chr12:38322083 C/A cg26384229 chr12:38710491 ALG10B 0.66 9.96 0.48 1.36e-20 Bladder cancer; CRC cis rs17023223 0.581 rs12064109 chr1:119642296 T/C cg05756136 chr1:119680316 WARS2 -0.52 -6.56 -0.34 2.15e-10 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for BMI in active individuals; CRC cis rs7666738 0.830 rs28594127 chr4:99001121 T/G cg05340658 chr4:99064831 C4orf37 0.61 9.54 0.47 3.44e-19 Colonoscopy-negative controls vs population controls; CRC cis rs7727544 0.836 rs10463892 chr5:131598705 T/C cg20512303 chr5:131592959 PDLIM4 0.29 5.74 0.3 2.1e-8 Blood metabolite levels; CRC cis rs1059312 1.000 rs1059312 chr12:129278864 A/G cg21616243 chr12:129299702 MGC16384;SLC15A4 0.62 10.02 0.48 8.63e-21 Systemic lupus erythematosus; CRC cis rs62283056 0.512 rs4568307 chr4:6284965 A/G cg25554036 chr4:6271136 WFS1 0.45 6.6 0.34 1.63e-10 Cisplatin-induced ototoxicity; CRC cis rs7680126 0.633 rs11728093 chr4:10296407 A/C cg11266682 chr4:10021025 SLC2A9 -0.48 -7.27 -0.37 2.61e-12 Urate levels in lean individuals;Urate levels in overweight individuals;Urate levels in obese individuals; CRC trans rs12432203 1.000 rs72622442 chr14:51744868 A/G cg14592830 chr9:122318704 NA 0.59 5.98 0.31 5.91e-9 Cancer; CRC cis rs11628318 0.763 rs11623312 chr14:103022060 G/T cg23461800 chr14:103021989 NA -0.69 -8.89 -0.44 4.25e-17 Platelet count; CRC cis rs155076 1.000 rs9509638 chr13:21860193 G/A cg25811766 chr13:21894605 NA -0.57 -5.89 -0.31 9.71e-9 White matter hyperintensity burden; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg26057283 chr7:73082469 VPS37D 0.37 6.93 0.36 2.22e-11 Liver disease severity in Alagille syndrome; CRC cis rs524281 0.817 rs10791859 chr11:65978453 C/T cg14036092 chr11:66035641 RAB1B -0.52 -6.11 -0.32 2.89e-9 Electroencephalogram traits; CRC cis rs2976388 0.590 rs7828042 chr8:143819383 A/G cg24634471 chr8:143751801 JRK -0.45 -6.38 -0.33 5.86e-10 Urinary tract infection frequency; CRC cis rs9467711 0.606 rs9358939 chr6:26416787 C/G cg12315302 chr6:26189340 HIST1H4D 0.77 5.99 0.31 5.51e-9 Autism spectrum disorder or schizophrenia; CRC cis rs6089584 0.888 rs6061405 chr20:60617033 A/G cg13770153 chr20:60521292 NA -0.56 -8.37 -0.42 1.63e-15 Body mass index; CRC trans rs7615952 0.512 rs4679430 chr3:125357893 T/C cg08546805 chr12:8549446 NA -0.43 -6.55 -0.34 2.26e-10 Blood pressure (smoking interaction); CRC cis rs853679 0.517 rs9393890 chr6:28063855 C/T cg21251018 chr6:28226885 NKAPL 0.48 6.26 0.33 1.17e-9 Depression; CRC cis rs4731207 0.698 rs10255209 chr7:124554927 C/T cg23710748 chr7:124431027 NA -0.38 -6.02 -0.32 4.57e-9 Cutaneous malignant melanoma; CRC cis rs2050392 0.517 rs160017 chr10:30772894 A/G cg18806716 chr10:30721971 MAP3K8 -0.55 -7.52 -0.38 5.39e-13 Inflammatory bowel disease; CRC cis rs7618915 1.000 rs7618915 chr3:52279594 G/A cg18404041 chr3:52824283 ITIH1 -0.36 -6.63 -0.34 1.38e-10 Bipolar disorder; CRC cis rs12155623 0.668 rs6472114 chr8:49789561 T/C cg22283653 chr8:49824208 NA -0.37 -6.15 -0.32 2.2e-9 Sudden cardiac arrest; CRC cis rs17270561 0.636 rs11794 chr6:25701718 G/A cg16482183 chr6:26056742 HIST1H1C 0.78 9.68 0.47 1.15e-19 Iron status biomarkers; CRC cis rs10504073 0.647 rs56057508 chr8:49982793 G/T cg00325661 chr8:49890786 NA 0.51 8.91 0.44 3.44e-17 Blood metabolite ratios; CRC cis rs78456975 1.000 rs111935361 chr2:1554192 C/A cg01028140 chr2:1542097 TPO -0.56 -5.73 -0.3 2.25e-8 Placebo response in major depressive disorder (% change in symptom score); CRC cis rs8078723 1.000 rs3826331 chr17:38150492 T/C cg17467752 chr17:38218738 THRA -0.74 -11.98 -0.55 1.12e-27 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); CRC cis rs12580194 0.556 rs12099811 chr12:55731200 T/A cg23425280 chr12:56401806 NA 0.47 5.86 0.31 1.1e-8 Cancer; CRC cis rs12042938 1.000 rs823158 chr1:231782650 C/T cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX 0.5 7.07 0.36 9.56e-12 Neuranatomic and neurocognitive phenotypes; CRC cis rs12148488 0.966 rs12899062 chr15:75347641 A/C cg17294928 chr15:75287854 SCAMP5 -0.43 -6.44 -0.33 4.12e-10 Caffeine consumption; CRC cis rs1552244 1.000 rs17032278 chr3:10077955 A/G cg18598329 chr3:10140678 FANCD2;C3orf24 -0.89 -11.87 -0.55 2.69e-27 Alzheimer's disease; CRC cis rs3026101 0.671 rs8077472 chr17:5299359 C/T cg25236894 chr17:5323110 RPAIN;NUP88 0.42 6.9 0.36 2.74e-11 Body mass index; CRC cis rs7772486 0.790 rs4435956 chr6:146232403 G/C cg13319975 chr6:146136371 FBXO30 0.41 6.15 0.32 2.25e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs7618915 0.501 rs7611731 chr3:52692721 T/C cg08222913 chr3:52553049 STAB1 -0.34 -6.26 -0.33 1.22e-9 Bipolar disorder; CRC cis rs2032447 0.899 rs1090947 chr6:26076642 T/C cg03264133 chr6:25882463 NA -0.46 -6.35 -0.33 7.02e-10 Intelligence (multi-trait analysis); CRC cis rs9648716 0.554 rs4726020 chr7:140603652 A/G cg10747023 chr7:140774559 NA 0.46 6.3 0.33 9.52e-10 Type 2 diabetes; CRC cis rs6502050 0.769 rs4789741 chr17:80119184 A/C cg25804541 chr17:80189381 SLC16A3 -0.31 -5.96 -0.31 6.46e-9 Life satisfaction; CRC cis rs7809950 1.000 rs2293658 chr7:107270567 C/T cg23024343 chr7:107201750 COG5 -0.64 -9.45 -0.46 6.64e-19 Coronary artery disease; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg02281514 chr2:216946545 PECR;TMEM169 0.45 6.04 0.32 4.14e-9 Anxiety disorder; CRC cis rs7833790 0.660 rs7839178 chr8:82763479 A/G cg17211192 chr8:82754475 SNX16 0.48 6.79 0.35 5.38e-11 Diastolic blood pressure; CRC cis rs60871478 0.636 rs4721834 chr7:896142 C/T cg05535760 chr7:792225 HEATR2 -0.9 -10.09 -0.49 5.02e-21 Cerebrospinal P-tau181p levels; CRC cis rs7937682 0.602 rs11214036 chr11:111773169 C/T cg09085632 chr11:111637200 PPP2R1B -0.9 -15.63 -0.65 1.36e-41 Primary sclerosing cholangitis; CRC cis rs1552244 0.935 rs7621551 chr3:10114205 C/T cg10729496 chr3:10149963 C3orf24 0.55 7.26 0.37 2.73e-12 Alzheimer's disease; CRC cis rs7131987 0.903 rs7970390 chr12:29398655 A/G cg09582351 chr12:29534625 ERGIC2 -0.29 -6.15 -0.32 2.28e-9 QT interval; CRC cis rs11148252 0.574 rs3742297 chr13:53278067 T/C cg20354231 chr13:53171401 NA -0.46 -7.38 -0.38 1.31e-12 Lewy body disease; CRC cis rs11719291 0.833 rs34037363 chr3:48821036 C/T cg00383909 chr3:49044727 WDR6 1.31 12.57 0.57 7.47e-30 Cognitive function; CRC cis rs400736 0.562 rs12711516 chr1:8181227 G/C cg25007680 chr1:8021821 PARK7 -0.44 -5.82 -0.31 1.39e-8 Response to antidepressants and depression; CRC cis rs116095464 0.619 rs2303741 chr5:218356 T/C cg22496380 chr5:211416 CCDC127 -0.83 -9.55 -0.47 3.03e-19 Breast cancer; CRC cis rs4728302 0.869 rs889825 chr7:133596227 A/G cg03336402 chr7:133662267 EXOC4 -0.45 -6.51 -0.34 2.78e-10 Intelligence;Intelligence (multi-trait analysis); CRC cis rs7932354 0.528 rs4752957 chr11:47125632 T/G cg19486271 chr11:47235900 DDB2 -0.45 -6.73 -0.35 7.77e-11 Bone mineral density (hip);Bone mineral density; CRC cis rs4132509 1.000 rs2168812 chr1:243777066 G/A cg21452805 chr1:244014465 NA 0.46 6.11 0.32 2.78e-9 RR interval (heart rate); CRC cis rs523522 1.000 rs523522 chr12:121020250 A/T cg27279351 chr12:120934652 DYNLL1 0.74 10.49 0.5 2.08e-22 High light scatter reticulocyte count; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg09860653 chr1:19970708 NBL1 0.43 7.11 0.36 7.43e-12 Liver disease severity in Alagille syndrome; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg14905632 chr17:38333933 RAPGEFL1 0.4 6.12 0.32 2.64e-9 Intelligence (multi-trait analysis); CRC cis rs13118159 0.505 rs1250128 chr4:1257311 T/C cg05025164 chr4:1340916 KIAA1530 -0.58 -8.12 -0.41 9.73e-15 Longevity; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg10620100 chr15:40714174 NA 0.53 7.03 0.36 1.22e-11 Thyroid stimulating hormone; CRC cis rs9487051 0.714 rs9487053 chr6:109619697 T/C cg01475377 chr6:109611718 NA -0.39 -6.78 -0.35 5.51e-11 Reticulocyte fraction of red cells; CRC trans rs6788895 0.661 rs16862837 chr3:150469858 A/C cg02509730 chr13:100310205 CLYBL 0.6 6.17 0.32 2.04e-9 Breast cancer; CRC cis rs796364 0.951 rs12996313 chr2:200997916 C/T cg12253985 chr2:200820533 C2orf60;C2orf47 -0.56 -6.02 -0.31 4.73e-9 Schizophrenia; CRC cis rs7264396 0.887 rs8116304 chr20:34054409 C/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.38 -6.15 -0.32 2.24e-9 Total cholesterol levels; CRC cis rs7937682 0.855 rs539553 chr11:111477333 C/T cg09085632 chr11:111637200 PPP2R1B -0.98 -19.11 -0.73 2.63e-55 Primary sclerosing cholangitis; CRC cis rs7412746 0.586 rs2864882 chr1:150883037 C/T cg17724175 chr1:150552817 MCL1 0.39 6.0 0.31 5.11e-9 Melanoma; CRC cis rs17401966 0.858 rs61778404 chr1:10432879 A/G cg19773385 chr1:10388646 KIF1B -0.68 -11.04 -0.52 2.52e-24 Hepatocellular carcinoma; CRC cis rs7937682 0.793 rs4581484 chr11:111415822 G/A cg19812747 chr11:111475976 SIK2 0.42 6.16 0.32 2.17e-9 Primary sclerosing cholangitis; CRC cis rs7926971 0.704 rs4463830 chr11:12659331 C/T cg25843174 chr11:12811716 TEAD1 0.35 6.08 0.32 3.28e-9 Height; CRC cis rs60871478 1.000 rs12531530 chr7:827366 T/C cg05535760 chr7:792225 HEATR2 0.98 12.55 0.57 8.38e-30 Cerebrospinal P-tau181p levels; CRC cis rs1707322 0.752 rs10430105 chr1:46138876 G/A cg03146154 chr1:46216737 IPP 0.66 9.65 0.47 1.44e-19 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs765787 0.530 rs12915804 chr15:45512562 T/C cg24006582 chr15:45444508 DUOX1 0.52 7.52 0.38 5.41e-13 Uric acid levels; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg05886006 chr1:161359784 NA 0.44 6.27 0.33 1.11e-9 Response to antipsychotic treatment; CRC cis rs2354432 0.607 rs2297752 chr1:146765454 C/G cg25205988 chr1:146714368 CHD1L -1.14 -12.49 -0.57 1.4e-29 Mitochondrial DNA levels; CRC cis rs734999 0.566 rs6664969 chr1:2534978 G/A cg18854424 chr1:2615690 NA 0.4 7.6 0.39 3.18e-13 Ulcerative colitis; CRC cis rs7208859 0.673 rs36056619 chr17:29172284 T/C cg13385521 chr17:29058706 SUZ12P 0.69 8.02 0.4 1.81e-14 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs6089584 0.850 rs881993 chr20:60623862 A/G cg13770153 chr20:60521292 NA -0.6 -9.12 -0.45 7.5e-18 Body mass index; CRC trans rs7395662 1.000 rs10838971 chr11:48606624 C/T cg21153622 chr11:89784906 NA -0.48 -7.67 -0.39 1.95e-13 HDL cholesterol; CRC cis rs1570884 0.516 rs9535268 chr13:50175478 C/A cg08779649 chr13:50194554 NA 0.45 9.31 0.46 1.9e-18 Sum basophil neutrophil counts;Sum neutrophil eosinophil counts;Neutrophil count;Myeloid white cell count;Granulocyte count; CRC cis rs4243830 0.826 rs3908553 chr1:6621921 G/A cg22792644 chr1:6614718 TAS1R1;NOL9 0.85 7.49 0.38 6.52e-13 Body mass index; CRC cis rs798554 0.836 rs798526 chr7:2775542 G/C cg04166393 chr7:2884313 GNA12 0.49 6.76 0.35 6.47e-11 Height; CRC cis rs853679 0.599 rs156743 chr6:27967089 T/C cg03623178 chr6:28175578 NA 0.84 8.04 0.41 1.62e-14 Depression; CRC cis rs28386778 1.000 rs2955241 chr17:61968113 G/C cg22520471 chr17:61851767 DDX42;CCDC47 0.73 10.8 0.51 1.8e-23 Prudent dietary pattern; CRC cis rs4629180 0.586 rs290773 chr2:102125930 G/A cg01388757 chr2:102091195 RFX8 0.38 5.93 0.31 7.86e-9 Chronic rhinosinusitis with nasal polyps; CRC cis rs2243480 1.000 rs4145008 chr7:65647511 T/G cg12463550 chr7:65579703 CRCP -0.71 -6.52 -0.34 2.61e-10 Diabetic kidney disease; CRC cis rs769267 0.965 rs8103496 chr19:19386015 A/G cg20644253 chr19:19431407 KIAA0892;SF4 0.43 5.97 0.31 6e-9 Tonsillectomy; CRC cis rs11123610 0.520 rs35752035 chr2:3721353 G/C cg00999904 chr2:3704751 ALLC -0.53 -6.66 -0.34 1.16e-10 Response to inhaled corticosteroid treatment in asthma (change in FEV1); CRC cis rs1865760 0.593 rs3903852 chr6:25915147 G/T cg03264133 chr6:25882463 NA -0.49 -7.33 -0.37 1.76e-12 Height; CRC cis rs12971120 0.947 rs8083001 chr18:72165058 A/G cg25817165 chr18:72167213 CNDP2 -0.66 -11.36 -0.53 1.81e-25 Refractive error; CRC trans rs1455244 0.700 rs7229302 chr18:11508904 G/T cg10836036 chr1:155278714 FDPS 0.41 6.53 0.34 2.55e-10 Schizophrenia; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg12672932 chr2:153575114 ARL6IP6;PRPF40A 0.44 5.97 0.31 6.22e-9 Anxiety disorder; CRC cis rs12541335 0.639 rs6993855 chr8:22163797 A/G cg26039829 chr8:22132926 PIWIL2 0.52 9.37 0.46 1.22e-18 Hypertriglyceridemia; CRC cis rs12681287 0.640 rs4587306 chr8:87385511 T/C cg27223183 chr8:87520930 FAM82B 0.52 7.07 0.36 9.37e-12 Caudate activity during reward; CRC trans rs2303319 0.504 rs62189041 chr2:162599506 T/C cg04551154 chr10:95462393 C10orf4 -0.75 -6.37 -0.33 6.43e-10 Cognitive function; CRC trans rs1973993 0.672 rs17367240 chr1:96960057 G/A cg10631902 chr5:14652156 NA -0.42 -7.14 -0.37 6.16e-12 Weight; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg15459342 chr1:228296991 MRPL55 0.46 6.48 0.34 3.3e-10 Response to antipsychotic treatment; CRC cis rs4713118 0.513 rs149950 chr6:28033039 T/G cg02683197 chr6:28174875 NA 0.62 8.5 0.42 6.91e-16 Parkinson's disease; CRC cis rs9486715 0.867 rs9373833 chr6:96904998 A/G cg06623918 chr6:96969491 KIAA0776 -1.01 -20.09 -0.74 3.73e-59 Headache; CRC cis rs17384381 0.953 rs11161597 chr1:85784936 G/A cg16011679 chr1:85725395 C1orf52 0.67 6.95 0.36 1.98e-11 Lobe attachment (rater-scored or self-reported); CRC cis rs79349575 0.783 rs11079844 chr17:47028334 G/A cg00947319 chr17:47005597 UBE2Z -0.33 -5.67 -0.3 3.19e-8 Type 2 diabetes; CRC cis rs728616 0.867 rs17886286 chr10:81703852 C/G cg11900509 chr10:81946545 ANXA11 -0.65 -6.56 -0.34 2.06e-10 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs55823223 0.590 rs11870142 chr17:73859002 A/G cg14829360 chr17:73884958 NA -0.43 -6.67 -0.34 1.11e-10 Psoriasis; CRC cis rs7618915 0.547 rs12486847 chr3:52691112 T/C cg07507251 chr3:52567010 NT5DC2 0.46 6.6 0.34 1.68e-10 Bipolar disorder; CRC cis rs6540556 0.608 rs4844891 chr1:209914409 A/C cg23920097 chr1:209922102 NA -0.48 -5.85 -0.31 1.22e-8 Red blood cell count; CRC cis rs2243480 1.000 rs778729 chr7:65824419 T/C cg25985355 chr7:65971099 NA -0.53 -5.99 -0.31 5.45e-9 Diabetic kidney disease; CRC cis rs6540559 0.546 rs57315825 chr1:210030197 C/T cg22029157 chr1:209979665 IRF6 0.6 7.59 0.39 3.27e-13 Cleft lip with or without cleft palate; CRC cis rs10504229 0.906 rs17805439 chr8:58172400 T/C cg02725872 chr8:58115012 NA -0.38 -6.43 -0.33 4.44e-10 Developmental language disorder (linguistic errors); CRC cis rs9916302 0.904 rs9898773 chr17:37532507 C/G cg15445000 chr17:37608096 MED1 -0.44 -9.71 -0.47 9.36e-20 Glomerular filtration rate (creatinine); CRC cis rs7914558 0.966 rs10450373 chr10:104728616 T/C cg15744005 chr10:104629667 AS3MT -0.34 -7.4 -0.38 1.12e-12 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs1816752 0.774 rs7986162 chr13:25000079 C/T cg02811702 chr13:24901961 NA 0.45 6.22 0.32 1.53e-9 Obesity-related traits; CRC cis rs7020830 0.789 rs17408112 chr9:37114065 A/G cg14294708 chr9:37120828 ZCCHC7 1.18 26.37 0.82 3.89e-83 Schizophrenia; CRC cis rs2836974 0.644 rs4818017 chr21:40690561 G/T cg17971929 chr21:40555470 PSMG1 -0.62 -9.05 -0.45 1.32e-17 Cognitive function; CRC cis rs1506636 0.708 rs7788702 chr7:123237421 C/T cg03229431 chr7:123269106 ASB15 0.61 8.83 0.44 6.5e-17 Plateletcrit;Platelet count; CRC cis rs7312933 0.703 rs7957471 chr12:42545591 G/T cg19980929 chr12:42632907 YAF2 0.43 6.42 0.33 4.87e-10 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CRC trans rs3780486 0.846 rs3780490 chr9:33129839 A/G cg04842962 chr6:43655489 MRPS18A 1.16 25.92 0.82 1.73e-81 IgG glycosylation; CRC cis rs2742417 0.603 rs13059502 chr3:45781380 A/G cg04837898 chr3:45731254 SACM1L -0.48 -7.72 -0.39 1.45e-13 Response to anti-depressant treatment in major depressive disorder; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg19350839 chr7:65338055 VKORC1L1 0.39 6.75 0.35 6.63e-11 Liver disease severity in Alagille syndrome; CRC cis rs6598955 0.670 rs7531518 chr1:26539749 T/C cg00852783 chr1:26633632 UBXN11 0.46 7.36 0.38 1.5e-12 Obesity-related traits; CRC cis rs71403859 0.730 rs71386933 chr16:71821800 A/T cg08717414 chr16:71523259 ZNF19 -1.07 -9.6 -0.47 2.1e-19 Post bronchodilator FEV1; CRC cis rs2635047 0.967 rs7242978 chr18:44633424 G/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 -0.44 -6.76 -0.35 6.21e-11 Educational attainment; CRC cis rs6754311 0.773 rs666407 chr2:136640233 A/G cg15123519 chr2:136567270 LCT -0.35 -6.74 -0.35 6.96e-11 Mosquito bite size; CRC trans rs916888 0.779 rs430685 chr17:44859148 T/C cg10053473 chr17:62856997 LRRC37A3 0.71 8.39 0.42 1.42e-15 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC trans rs10983614 1.000 rs7867776 chr9:120072627 A/G cg01073178 chr12:117537710 TESC 0.43 6.01 0.31 4.96e-9 Survival in pancreatic cancer; CRC cis rs877282 0.838 rs11253408 chr10:796374 T/C cg06581033 chr10:766294 NA -0.51 -5.68 -0.3 2.97e-8 Uric acid levels; CRC cis rs11976180 0.569 rs12703565 chr7:143754401 C/T cg16347377 chr7:143956670 OR2A7 -0.55 -6.39 -0.33 5.67e-10 Obesity-related traits; CRC cis rs3617 0.625 rs2336558 chr3:52886240 C/T cg07507251 chr3:52567010 NT5DC2 -0.4 -6.25 -0.33 1.29e-9 Red blood cell count;Autism spectrum disorder or schizophrenia; CRC cis rs4722166 0.630 rs12700391 chr7:22777327 C/A cg26061582 chr7:22766209 IL6 0.55 8.35 0.42 1.92e-15 Lung cancer; CRC cis rs1153858 0.943 rs4774580 chr15:45652086 G/A cg10760299 chr15:45669010 GATM 0.52 8.31 0.42 2.58e-15 Homoarginine levels; CRC cis rs67311347 0.955 rs73080163 chr3:40533061 G/T cg09455208 chr3:40491958 NA 0.43 8.21 0.41 5.2e-15 Renal cell carcinoma; CRC cis rs1003719 0.628 rs2835635 chr21:38528866 A/G cg10648535 chr21:38446584 PIGP;TTC3 -0.44 -6.25 -0.33 1.31e-9 Eye color traits; CRC cis rs4474465 0.850 rs7127028 chr11:78262324 A/G cg02023728 chr11:77925099 USP35 -0.36 -6.16 -0.32 2.12e-9 Alzheimer's disease (survival time); CRC cis rs6952808 0.825 rs11761818 chr7:1935273 C/T cg22963979 chr7:1858916 MAD1L1 -0.5 -7.46 -0.38 7.57e-13 Bipolar disorder and schizophrenia; CRC cis rs9611565 0.512 rs139571 chr22:42214238 G/A cg03806693 chr22:41940476 POLR3H -1.09 -13.1 -0.59 7.99e-32 Vitiligo; CRC cis rs4713118 0.955 rs9380010 chr6:27683572 A/G cg12273811 chr6:28175739 NA 0.51 6.99 0.36 1.49e-11 Parkinson's disease; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg05193430 chr14:68086242 ARG2 0.41 6.09 0.32 3.14e-9 Liver disease severity in Alagille syndrome; CRC cis rs7552404 1.000 rs11161510 chr1:76210289 A/G cg03433033 chr1:76189801 ACADM -0.81 -11.1 -0.52 1.55e-24 Blood metabolite levels;Acylcarnitine levels; CRC cis rs3106136 0.527 rs10030586 chr4:95150805 A/C cg11021082 chr4:95130006 SMARCAD1 -0.59 -9.33 -0.46 1.65e-18 Capecitabine sensitivity; CRC cis rs3806843 0.576 rs246024 chr5:140333952 C/T cg19875535 chr5:140030758 IK 0.4 6.12 0.32 2.64e-9 Depressive symptoms (multi-trait analysis); CRC cis rs8031584 0.918 rs34693097 chr15:31253984 A/G cg08704250 chr15:31115839 NA -0.45 -8.3 -0.42 2.78e-15 Huntington's disease progression; CRC cis rs7726839 0.540 rs4957080 chr5:644552 A/C cg17948913 chr5:572064 NA -0.5 -5.74 -0.3 2.11e-8 Obesity-related traits; CRC cis rs62229266 0.804 rs56279140 chr21:37424361 C/T cg12218747 chr21:37451666 NA -0.45 -7.8 -0.39 8.38e-14 Mitral valve prolapse; CRC trans rs9858542 1.000 rs11130213 chr3:49712297 C/T cg21665057 chr3:196295764 WDR53;FBXO45 -0.66 -8.59 -0.43 3.49e-16 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs2274273 0.638 rs3825614 chr14:55729387 G/A cg10130446 chr14:55658398 DLGAP5 -0.45 -6.07 -0.32 3.58e-9 Protein biomarker; CRC trans rs204595 0.965 rs204585 chr7:20902288 A/G cg02372745 chr13:50365574 KPNA3 0.47 6.26 0.33 1.22e-9 Depressive symptoms (stressful life events interaction); CRC cis rs3026101 0.671 rs3026134 chr17:5309690 G/C cg25236894 chr17:5323110 RPAIN;NUP88 0.42 6.9 0.36 2.74e-11 Body mass index; CRC cis rs10760158 0.768 rs2149805 chr9:124021499 T/G cg14417974 chr9:124058376 GSN -0.34 -5.68 -0.3 2.96e-8 Pulse pressure; CRC trans rs3733585 0.638 rs17185835 chr4:9958180 T/G cg26043149 chr18:55253948 FECH -0.5 -7.65 -0.39 2.21e-13 Cleft plate (environmental tobacco smoke interaction); CRC cis rs9916302 0.904 rs12600751 chr17:37553651 G/C cg00129232 chr17:37814104 STARD3 0.54 7.59 0.39 3.27e-13 Glomerular filtration rate (creatinine); CRC cis rs4662945 0.603 rs1453147 chr2:130271510 A/C cg05962382 chr2:130345044 NA -0.45 -7.84 -0.4 6.13e-14 Response to cytidine analogues (gemcitabine); CRC cis rs1008375 0.932 rs7677212 chr4:17675932 A/G cg16339924 chr4:17578868 LAP3 -0.51 -6.69 -0.35 9.48e-11 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs28386778 0.897 rs7210443 chr17:61785374 A/G cg22520471 chr17:61851767 DDX42;CCDC47 0.74 11.39 0.53 1.47e-25 Prudent dietary pattern; CRC cis rs853679 0.506 rs1150693 chr6:28174590 T/C cg12963246 chr6:28129442 ZNF389 0.45 5.67 0.3 3.2e-8 Depression; CRC cis rs739401 0.611 rs3782069 chr11:3033275 G/A cg25174290 chr11:3078921 CARS 0.47 7.19 0.37 4.44e-12 Longevity; CRC cis rs870825 0.616 rs28620459 chr4:185627132 G/C cg04058563 chr4:185651563 MLF1IP 0.72 9.38 0.46 1.12e-18 Blood protein levels; CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg18462168 chr15:22892545 CYFIP1 -0.55 -6.64 -0.34 1.26e-10 Diisocyanate-induced asthma; CRC cis rs12541335 0.639 rs7834182 chr8:22163112 G/A cg26039829 chr8:22132926 PIWIL2 0.51 9.07 0.45 1.13e-17 Hypertriglyceridemia; CRC trans rs3087591 0.959 rs8076441 chr17:29405878 C/T cg02257048 chr17:78880031 RPTOR -0.39 -6.09 -0.32 3.21e-9 Hip circumference; CRC cis rs734999 0.572 rs3748816 chr1:2526746 A/G cg20673091 chr1:2541236 MMEL1 0.36 5.82 0.31 1.43e-8 Ulcerative colitis; CRC cis rs10128264 0.934 rs1250590 chr10:80983786 A/C cg20744163 chr10:80999841 ZMIZ1 0.44 7.67 0.39 2e-13 Response to methotrexate in juvenile idiopathic arthritis; CRC cis rs9322193 0.923 rs9968911 chr6:149978555 A/T cg13206674 chr6:150067644 NUP43 0.64 9.65 0.47 1.45e-19 Lung cancer; CRC cis rs8062405 0.755 rs7186573 chr16:28587389 T/C cg05139728 chr16:28306816 SBK1 -0.38 -6.25 -0.33 1.28e-9 Cognitive ability (multi-trait analysis);Cognitive ability; CRC cis rs4481887 0.893 rs7515080 chr1:248494073 A/G cg13385794 chr1:248469461 NA 0.39 6.65 0.34 1.23e-10 Common traits (Other); CRC cis rs8177179 0.967 rs4994582 chr3:133437566 G/C cg16262614 chr3:133464971 TF 0.44 8.19 0.41 5.85e-15 Iron status biomarkers (transferrin levels); CRC cis rs7618915 0.547 rs62253733 chr3:52653414 A/G cg07507251 chr3:52567010 NT5DC2 0.46 6.68 0.35 1.01e-10 Bipolar disorder; CRC cis rs7674212 0.539 rs6850461 chr4:104120041 C/T cg16532752 chr4:104119610 CENPE -0.41 -5.81 -0.31 1.45e-8 Type 2 diabetes; CRC cis rs1005277 0.579 rs176880 chr10:38401417 C/G cg25517755 chr10:38738941 LOC399744 0.45 6.56 0.34 2.07e-10 Extrinsic epigenetic age acceleration; CRC cis rs2384207 0.818 rs7299870 chr12:113708590 A/G cg22376712 chr12:113623594 C12orf52;DDX54 0.51 6.38 0.33 5.96e-10 Response to fenofibrate (adiponectin levels); CRC cis rs6964587 1.000 rs28927678 chr7:91715662 C/T cg17063962 chr7:91808500 NA 0.76 12.23 0.56 1.37e-28 Breast cancer; CRC cis rs1992660 0.523 rs6897022 chr5:40336546 A/G cg09067459 chr5:40385259 NA -0.44 -7.46 -0.38 7.7e-13 Crohn's disease; CRC cis rs875971 0.642 rs35526611 chr7:66094008 C/T cg11764359 chr7:65958608 NA -0.54 -8.38 -0.42 1.59e-15 Aortic root size; CRC cis rs6496667 0.600 rs9806361 chr15:91073867 G/A cg04176472 chr15:90893244 GABARAPL3 0.49 7.23 0.37 3.45e-12 Rheumatoid arthritis; CRC cis rs28386778 0.897 rs2044125 chr17:61863184 A/C cg23090583 chr17:61904693 PSMC5;FTSJ3 -1.01 -19.38 -0.73 2.36e-56 Prudent dietary pattern; CRC cis rs9905704 0.647 rs2036730 chr17:57038282 A/G cg12560992 chr17:57184187 TRIM37 0.63 9.54 0.47 3.43e-19 Testicular germ cell tumor; CRC cis rs2075371 0.966 rs2244690 chr7:133987039 A/G cg11752832 chr7:134001865 SLC35B4 0.5 7.75 0.39 1.19e-13 Mean platelet volume; CRC cis rs72717009 0.825 rs867624 chr1:161467837 A/T cg10431340 chr1:161279108 MPZ -0.56 -7.38 -0.38 1.32e-12 Rheumatoid arthritis; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg20843052 chr2:61293725 KIAA1841 0.49 7.76 0.39 1.06e-13 Response to antipsychotic treatment; CRC cis rs1577917 1.000 rs12664335 chr6:86597774 C/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A 0.53 6.74 0.35 7.22e-11 Response to antipsychotic treatment; CRC cis rs6840360 0.533 rs13119490 chr4:152713412 A/G cg09659197 chr4:152720779 NA -0.44 -8.63 -0.43 2.64e-16 Intelligence (multi-trait analysis); CRC cis rs9326248 0.861 rs4938348 chr11:117021877 G/C cg11861562 chr11:117069780 TAGLN 0.35 6.42 0.33 4.82e-10 Blood protein levels; CRC cis rs6952808 0.723 rs4721295 chr7:2036669 G/T cg02951883 chr7:2050386 MAD1L1 0.77 13.1 0.59 7.48e-32 Bipolar disorder and schizophrenia; CRC cis rs34779708 0.898 rs11595898 chr10:35326263 T/C cg03585969 chr10:35415529 CREM 0.65 8.64 0.43 2.46e-16 Inflammatory bowel disease;Crohn's disease; CRC cis rs12541635 0.966 rs12680670 chr8:107006811 T/G cg10147462 chr8:107024639 NA 0.42 6.92 0.36 2.42e-11 Age of smoking initiation; CRC cis rs2067615 0.579 rs10507214 chr12:107194461 G/A cg15890332 chr12:107067104 RFX4 0.32 5.63 0.3 3.78e-8 Heart rate; CRC cis rs10849893 0.595 rs6489811 chr12:121893626 C/T cg01154721 chr12:121881891 KDM2B 0.45 6.57 0.34 1.97e-10 Fasting blood glucose;Fasting blood glucose (BMI interaction); CRC cis rs9291683 0.517 rs11736479 chr4:10017387 G/C cg00071950 chr4:10020882 SLC2A9 0.68 13.33 0.59 1.07e-32 Bone mineral density; CRC cis rs3772130 0.962 rs6791046 chr3:121394707 A/G cg20356878 chr3:121714668 ILDR1 0.5 7.7 0.39 1.63e-13 Cognitive performance; CRC cis rs10911363 0.592 rs10797886 chr1:183479090 T/C cg09173681 chr1:183549694 NCF2 0.74 10.46 0.5 2.64e-22 Systemic lupus erythematosus; CRC cis rs1552244 1.000 rs9834980 chr3:10065528 G/A cg16606324 chr3:10149918 C3orf24 0.69 9.43 0.46 7.91e-19 Alzheimer's disease; CRC cis rs6840360 1.000 rs6841783 chr4:152598876 C/G cg09659197 chr4:152720779 NA 0.52 11.3 0.53 3.04e-25 Intelligence (multi-trait analysis); CRC cis rs4332037 0.722 rs4721140 chr7:1917635 A/T cg24505167 chr7:1915268 MAD1L1 -0.49 -7.47 -0.38 7.32e-13 Bipolar disorder; CRC cis rs3751196 0.808 rs17034648 chr12:104219000 C/T cg02344784 chr12:104178138 NT5DC3 0.65 7.07 0.36 9.27e-12 Sense of smell; CRC cis rs4780401 0.728 rs8191290 chr16:11765954 C/A cg01061890 chr16:11836724 TXNDC11 -0.41 -5.62 -0.3 4.17e-8 Rheumatoid arthritis; CRC cis rs561341 0.739 rs8070554 chr17:30216868 A/T cg00745463 chr17:30367425 LRRC37B 0.58 7.67 0.39 1.93e-13 Hip circumference adjusted for BMI; CRC cis rs7208859 0.524 rs28760584 chr17:29141017 G/A cg13385521 chr17:29058706 SUZ12P 0.74 8.44 0.42 9.97e-16 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs801193 0.967 rs2707849 chr7:66152712 T/C cg05627663 chr7:65219948 SNORA22;CCT6P1 0.43 6.32 0.33 8.41e-10 Aortic root size; CRC cis rs3018066 0.867 rs10008428 chr4:107081028 G/T cg01869342 chr4:106983673 TBCK 0.37 5.74 0.3 2.15e-8 Cancer; CRC cis rs1005277 0.579 rs2504143 chr10:38383706 C/T cg00409905 chr10:38381863 ZNF37A -0.68 -11.27 -0.53 3.85e-25 Extrinsic epigenetic age acceleration; CRC cis rs4713118 0.513 rs149989 chr6:27998184 T/A cg15845792 chr6:28175446 NA 0.75 11.17 0.52 8.62e-25 Parkinson's disease; CRC cis rs7786808 0.564 rs10267128 chr7:158198490 G/A cg01191920 chr7:158217561 PTPRN2 0.58 9.28 0.46 2.39e-18 Obesity-related traits; CRC cis rs6460942 0.915 rs17541242 chr7:12459068 A/G cg06484146 chr7:12443880 VWDE -0.78 -8.1 -0.41 1.11e-14 Coronary artery disease; CRC cis rs7618501 0.521 rs868891 chr3:49949071 A/G cg05623727 chr3:50126028 RBM5 0.61 10.52 0.5 1.62e-22 Intelligence (multi-trait analysis); CRC cis rs2742540 0.503 rs982273 chr11:8906862 T/G cg21881798 chr11:8931708 C11orf17;ST5 -0.49 -7.45 -0.38 8.18e-13 Hematocrit; CRC cis rs11711311 1.000 rs9811200 chr3:113531180 A/T cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.52 -7.08 -0.36 8.94e-12 IgG glycosylation; CRC cis rs3018066 0.867 rs10004611 chr4:107092820 A/G cg01869342 chr4:106983673 TBCK 0.37 5.7 0.3 2.73e-8 Cancer; CRC cis rs6121246 0.559 rs12479491 chr20:30265450 T/C cg13852791 chr20:30311386 BCL2L1 0.71 13.73 0.6 3.21e-34 Mean corpuscular hemoglobin; CRC trans rs11098499 0.863 rs11098532 chr4:120490726 C/A cg25214090 chr10:38739885 LOC399744 0.67 10.33 0.49 7.69e-22 Corneal astigmatism; CRC cis rs9942416 0.660 rs1817869 chr5:74989037 T/C cg00601450 chr5:74908170 NA 0.41 5.76 0.3 1.95e-8 Age-related disease endophenotypes; CRC cis rs7605827 0.930 rs1024869 chr2:15549043 G/C cg19274914 chr2:15703543 NA 0.39 5.88 0.31 9.98e-9 Educational attainment (years of education); CRC cis rs62244186 0.748 rs2888410 chr3:44655476 A/C cg11003573 chr3:44754125 ZNF502 -0.36 -6.16 -0.32 2.11e-9 Depressive symptoms; CRC cis rs59104589 0.617 rs61615527 chr2:242342768 T/A cg19488206 chr2:242435732 STK25 0.43 6.33 0.33 7.84e-10 Fibrinogen levels; CRC cis rs2839186 1.000 rs2839186 chr21:47690068 C/T cg13126279 chr21:47581558 C21orf56 -0.38 -5.63 -0.3 3.9e-8 Testicular germ cell tumor; CRC cis rs1448094 0.817 rs11117115 chr12:86331021 A/G cg25456477 chr12:86230367 RASSF9 0.34 5.74 0.3 2.14e-8 Major depressive disorder; CRC cis rs9467711 0.651 rs2237228 chr6:26104630 C/T cg08501292 chr6:25962987 TRIM38 0.86 8.01 0.4 2.02e-14 Autism spectrum disorder or schizophrenia; CRC cis rs6582630 0.519 rs80226845 chr12:38528231 C/A cg26384229 chr12:38710491 ALG10B 0.71 10.13 0.49 3.74e-21 Drug-induced liver injury (flucloxacillin); CRC cis rs7312933 1.000 rs7957213 chr12:42475438 T/G cg01256987 chr12:42539512 GXYLT1 -0.43 -6.51 -0.34 2.83e-10 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CRC cis rs990171 1.000 rs6755786 chr2:103048103 C/T cg03938978 chr2:103052716 IL18RAP 0.46 5.9 0.31 9.09e-9 Lymphocyte counts; CRC cis rs9303401 0.659 rs35539277 chr17:56853833 G/A cg10487724 chr17:56770010 TEX14;RAD51C 0.76 9.04 0.45 1.42e-17 Cognitive test performance; CRC cis rs34375054 0.525 rs7133614 chr12:125605957 C/T cg25124228 chr12:125621409 AACS -0.65 -10.47 -0.5 2.45e-22 Post bronchodilator FEV1/FVC ratio; CRC cis rs7208859 0.673 rs11652370 chr17:29097223 G/A cg14008862 chr17:28927542 LRRC37B2 0.5 5.76 0.3 1.95e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs782590 0.967 rs4290693 chr2:55799991 C/G cg18811423 chr2:55921094 PNPT1 0.79 14.37 0.62 1.14e-36 Metabolic syndrome; CRC cis rs7394190 1.000 rs10824026 chr10:75421208 A/G cg26549892 chr10:75416844 SYNPO2L -0.45 -5.83 -0.31 1.34e-8 Incident atrial fibrillation; CRC cis rs11212617 0.935 rs227055 chr11:108261261 G/A cg12106634 chr11:108092400 ATM;NPAT 0.41 5.98 0.31 5.87e-9 Response to metformin in type 2 diabetes (glycemic); CRC cis rs6840360 0.582 rs57585665 chr4:152327017 G/C cg09659197 chr4:152720779 NA 0.3 5.66 0.3 3.28e-8 Intelligence (multi-trait analysis); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg17955752 chr17:79935872 ASPSCR1 0.4 6.06 0.32 3.79e-9 Intelligence (multi-trait analysis); CRC cis rs950169 0.519 rs7237 chr15:85186577 C/T cg11189052 chr15:85197271 WDR73 0.61 8.49 0.42 7.45e-16 Schizophrenia; CRC cis rs6500395 1.000 rs9937610 chr16:48671274 C/G cg04672837 chr16:48644449 N4BP1 0.42 6.2 0.32 1.66e-9 Response to tocilizumab in rheumatoid arthritis; CRC cis rs7666738 0.830 rs6839203 chr4:98839814 C/G cg05340658 chr4:99064831 C4orf37 0.54 7.88 0.4 4.91e-14 Colonoscopy-negative controls vs population controls; CRC cis rs10089 1.000 rs10060181 chr5:127475573 A/G cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.73 10.13 0.49 3.54e-21 Ileal carcinoids; CRC cis rs2415984 0.622 rs61993301 chr14:46949667 C/T cg14871534 chr14:47121158 RPL10L -0.44 -6.26 -0.33 1.22e-9 Number of children ever born; CRC cis rs35520189 0.556 rs12470439 chr2:113701164 G/A cg12858261 chr2:113808755 IL1F8 0.49 6.86 0.35 3.42e-11 Obstructive sleep apnea trait (apnea hypopnea index); CRC cis rs6952808 0.792 rs34269264 chr7:1948712 C/T cg04267008 chr7:1944627 MAD1L1 -0.83 -12.55 -0.57 8.82e-30 Bipolar disorder and schizophrenia; CRC cis rs4713675 0.510 rs1014933 chr6:33677235 A/G cg14003231 chr6:33640908 ITPR3 0.49 7.85 0.4 5.97e-14 Plateletcrit; CRC cis rs2361710 0.669 rs12940486 chr17:78118569 T/C cg20811857 chr17:78079795 GAA -0.41 -6.6 -0.34 1.69e-10 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count;Immature fraction of reticulocytes; CRC cis rs4713675 0.565 rs9469566 chr6:33667605 G/T cg14003231 chr6:33640908 ITPR3 0.49 7.69 0.39 1.71e-13 Plateletcrit; CRC cis rs6502050 0.799 rs7212023 chr17:80170354 G/A cg19223190 chr17:80058835 NA 0.42 6.74 0.35 7.27e-11 Life satisfaction; CRC cis rs8177253 1.000 rs8177261 chr3:133480588 A/C cg01448562 chr3:133502909 NA -0.53 -9.09 -0.45 9.72e-18 Iron status biomarkers; CRC cis rs4975616 0.836 rs460073 chr5:1336459 T/C cg06550200 chr5:1325588 CLPTM1L -0.74 -12.11 -0.56 3.73e-28 Lung cancer; CRC cis rs6076065 0.748 rs1016628 chr20:23398738 C/G cg11657817 chr20:23433608 CST11 -0.52 -8.55 -0.43 4.56e-16 Facial morphology (factor 15, philtrum width); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg05038121 chr15:80444758 FAH 0.49 6.8 0.35 4.92e-11 Response to antipsychotic treatment; CRC cis rs11252926 0.537 rs6560836 chr10:444997 C/T cg18196295 chr10:418757 DIP2C 0.49 7.64 0.39 2.37e-13 Psychosis in Alzheimer's disease; CRC cis rs28386778 0.897 rs8081454 chr17:61842646 A/G cg06873352 chr17:61820015 STRADA 0.79 14.96 0.64 5.82e-39 Prudent dietary pattern; CRC cis rs7613875 0.600 rs2624826 chr3:50155468 T/G cg05623727 chr3:50126028 RBM5 -0.62 -10.89 -0.51 8.94e-24 Body mass index; CRC cis rs6570726 0.791 rs365869 chr6:145884751 C/T cg23711669 chr6:146136114 FBXO30 0.77 13.51 0.6 2.14e-33 Lobe attachment (rater-scored or self-reported); CRC cis rs2411233 1.000 rs11070166 chr15:39280797 G/T cg23129342 chr15:39283510 NA 0.31 5.82 0.31 1.43e-8 Platelet count; CRC trans rs10982213 0.830 rs2274163 chr9:117188714 C/T cg00967121 chr5:153418461 MFAP3;FAM114A2 0.46 6.91 0.36 2.5e-11 Interleukin-6 levels; CRC cis rs887797 0.557 rs9909348 chr17:64576325 T/C cg27019712 chr17:64599478 PRKCA -0.37 -5.65 -0.3 3.56e-8 Possible neuropathic pain in post total joint replacement surgery for osteoarthritis; CRC cis rs6582630 0.502 rs12815350 chr12:38439921 A/T cg26384229 chr12:38710491 ALG10B 0.67 9.15 0.45 6.1e-18 Drug-induced liver injury (flucloxacillin); CRC cis rs1697139 0.563 rs6859520 chr5:66529020 C/T cg11553311 chr5:66541588 NA 0.59 9.99 0.48 1.05e-20 Breast cancer; CRC trans rs61931739 0.517 rs7975714 chr12:34055611 T/C cg26384229 chr12:38710491 ALG10B 0.53 6.77 0.35 5.85e-11 Morning vs. evening chronotype; CRC cis rs3736485 0.966 rs6493513 chr15:51910174 G/A cg08986416 chr15:51914746 DMXL2 -0.46 -6.49 -0.34 3.2e-10 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs12971120 0.891 rs3764510 chr18:72166846 A/G cg26446133 chr18:72167187 CNDP2 -0.77 -11.59 -0.54 2.88e-26 Refractive error; CRC cis rs7703744 0.681 rs73239278 chr5:118695051 G/A cg19893178 chr5:118692011 TNFAIP8 0.44 5.92 0.31 8.01e-9 Lobe attachment (rater-scored or self-reported); CRC trans rs7619427 0.544 rs58289556 chr3:44034726 C/T cg09408571 chr1:101003634 GPR88 0.46 6.26 0.33 1.17e-9 Schizophrenia; CRC cis rs832540 0.629 rs10461616 chr5:56080347 T/C cg18230493 chr5:56204884 C5orf35 -0.42 -6.07 -0.32 3.45e-9 Coronary artery disease; CRC trans rs1455244 0.700 rs7229302 chr18:11508904 G/T cg16311334 chr11:926082 AP2A2 0.39 6.0 0.31 5.12e-9 Schizophrenia; CRC cis rs752010 0.631 rs1073197 chr1:42059822 C/T cg06885757 chr1:42089581 HIVEP3 -0.6 -10.31 -0.49 8.78e-22 Lupus nephritis in systemic lupus erythematosus; CRC cis rs9527 0.590 rs7092029 chr10:104823909 A/T cg04362960 chr10:104952993 NT5C2 0.58 8.29 0.42 2.82e-15 Arsenic metabolism; CRC cis rs62064224 0.606 rs61390192 chr17:30837447 C/T cg01480708 chr17:30846118 MYO1D -0.37 -5.93 -0.31 7.73e-9 Schizophrenia; CRC cis rs4363385 0.818 rs10888526 chr1:153000311 G/T cg25856811 chr1:152973957 SPRR3 -0.25 -6.85 -0.35 3.73e-11 Inflammatory skin disease; CRC cis rs8180040 0.966 rs2101247 chr3:47494303 G/A cg10298567 chr3:47292165 KIF9 0.37 6.05 0.32 3.93e-9 Colorectal cancer; CRC cis rs875971 0.830 rs427973 chr7:65526648 C/A cg12463550 chr7:65579703 CRCP 0.46 6.5 0.34 3e-10 Aortic root size; CRC cis rs2050392 0.965 rs2480279 chr10:30700032 C/T cg18806716 chr10:30721971 MAP3K8 -0.47 -7.21 -0.37 3.85e-12 Inflammatory bowel disease; CRC cis rs6665290 0.870 rs1045289 chr1:227178713 C/T cg10327440 chr1:227177885 CDC42BPA -1.04 -23.9 -0.8 7.05e-74 Myeloid white cell count; CRC cis rs7937682 0.793 rs4581484 chr11:111415822 G/A cg09085632 chr11:111637200 PPP2R1B 0.64 8.99 0.44 2.04e-17 Primary sclerosing cholangitis; CRC cis rs977987 0.843 rs4888427 chr16:75478447 A/G cg03315344 chr16:75512273 CHST6 0.55 9.43 0.46 7.85e-19 Dupuytren's disease; CRC cis rs7937682 0.883 rs631490 chr11:111452040 G/C cg09085632 chr11:111637200 PPP2R1B -0.92 -17.16 -0.69 1.39e-47 Primary sclerosing cholangitis; CRC cis rs6502050 0.835 rs11658335 chr17:80084821 C/T cg22110888 chr17:80059540 CCDC57 -0.41 -6.39 -0.33 5.58e-10 Life satisfaction; CRC cis rs9443645 0.901 rs9352664 chr6:79566162 G/T cg05283184 chr6:79620031 NA -0.56 -9.02 -0.45 1.62e-17 Intelligence (multi-trait analysis); CRC cis rs9491140 0.539 rs12204076 chr6:124693493 A/G cg05308643 chr6:124982296 NKAIN2 0.51 6.83 0.35 4.05e-11 Neuroticism; CRC cis rs727563 0.636 rs2187795 chr22:42092225 C/A cg06481639 chr22:41940642 POLR3H 0.52 5.89 0.31 9.36e-9 Crohn's disease;Inflammatory bowel disease; CRC cis rs888194 0.677 rs2075431 chr12:109874621 C/T cg19025524 chr12:109796872 NA -0.39 -5.71 -0.3 2.52e-8 Neuroticism; CRC cis rs6963495 0.719 rs73190174 chr7:105161216 T/G cg02135003 chr7:105160482 PUS7 -0.9 -12.2 -0.56 1.71e-28 Bipolar disorder (body mass index interaction); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg02438591 chr16:2205559 TRAF7;SNORD60 0.4 6.0 0.31 5.32e-9 Response to antipsychotic treatment; CRC cis rs10256972 0.552 rs7805591 chr7:1210745 A/G cg03923535 chr7:1197113 ZFAND2A 0.77 11.7 0.54 1.12e-26 Longevity;Endometriosis; CRC trans rs9858542 0.953 rs9821311 chr3:49543656 C/T cg21582582 chr3:182698605 DCUN1D1 -0.51 -6.43 -0.33 4.42e-10 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs9487051 0.676 rs1608044 chr6:109594076 T/C cg12927641 chr6:109611667 NA -0.38 -6.77 -0.35 5.88e-11 Reticulocyte fraction of red cells; CRC cis rs3540 0.960 rs2238325 chr15:91011262 C/T cg04176472 chr15:90893244 GABARAPL3 -0.35 -6.02 -0.32 4.56e-9 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; CRC trans rs2303319 0.504 rs62189047 chr2:162613314 T/A cg22922770 chr7:98923339 ARPC1A -0.67 -5.98 -0.31 5.68e-9 Cognitive function; CRC cis rs7833790 0.700 rs28390260 chr8:82769175 A/T cg17211192 chr8:82754475 SNX16 0.47 6.62 0.34 1.47e-10 Diastolic blood pressure; CRC cis rs61774743 0.521 rs60144015 chr1:41845246 C/A cg01193554 chr1:41846683 NA -0.36 -5.89 -0.31 9.45e-9 Intelligence (multi-trait analysis); CRC cis rs2274273 0.588 rs17675223 chr14:55862236 G/A cg10130446 chr14:55658398 DLGAP5 -0.43 -5.92 -0.31 8.12e-9 Protein biomarker; CRC trans rs11098499 0.865 rs4507344 chr4:120307485 C/A cg25214090 chr10:38739885 LOC399744 0.62 9.74 0.47 7.35e-20 Corneal astigmatism; CRC cis rs9549328 0.800 rs9549326 chr13:113630453 C/T cg08614441 chr13:113633676 MCF2L -0.53 -9.4 -0.46 9.66e-19 Systolic blood pressure; CRC cis rs798554 0.836 rs798526 chr7:2775542 G/C cg19717773 chr7:2847554 GNA12 -0.44 -6.39 -0.33 5.75e-10 Height; CRC cis rs6952808 1.000 rs6954673 chr7:1886937 C/T cg21782813 chr7:2030301 MAD1L1 0.45 7.44 0.38 9.07e-13 Bipolar disorder and schizophrenia; CRC cis rs769267 0.930 rs7254748 chr19:19397479 A/C cg03709012 chr19:19516395 GATAD2A 0.71 10.97 0.52 4.39e-24 Tonsillectomy; CRC cis rs13191362 0.935 rs66507030 chr6:162953825 G/A cg21926612 chr6:163149169 PACRG;PARK2 0.81 10.03 0.48 7.81e-21 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs7666738 0.830 rs2019163 chr4:99022747 C/T cg05340658 chr4:99064831 C4orf37 0.61 9.51 0.46 4.05e-19 Colonoscopy-negative controls vs population controls; CRC trans rs17126268 0.502 rs6687748 chr1:102885219 T/C cg18468354 chr14:36993517 NA 0.38 6.12 0.32 2.65e-9 Glomerular filtration rate; CRC cis rs17376456 0.877 rs10076052 chr5:93317762 C/T cg25358565 chr5:93447407 FAM172A 1.06 10.59 0.5 9.22e-23 Diabetic retinopathy; CRC cis rs1048238 0.506 rs698890 chr1:16267371 C/G cg21385522 chr1:16154831 NA -0.61 -9.06 -0.45 1.16e-17 Systolic blood pressure; CRC cis rs4731207 0.698 rs7789859 chr7:124519472 C/G cg23710748 chr7:124431027 NA -0.38 -6.08 -0.32 3.42e-9 Cutaneous malignant melanoma; CRC cis rs2692947 0.673 rs4907279 chr2:96399968 G/C cg23100626 chr2:96804247 ASTL 0.28 7.14 0.37 6.15e-12 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; CRC cis rs5750830 0.649 rs4821894 chr22:39809820 G/C cg25956985 chr22:39795188 MAP3K7IP1 -0.48 -6.66 -0.34 1.18e-10 Intelligence (multi-trait analysis); CRC cis rs7216064 1.000 rs7216064 chr17:65898809 G/A cg12091567 chr17:66097778 LOC651250 -0.61 -7.11 -0.36 7.24e-12 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CRC cis rs6504622 0.967 rs11869840 chr17:44996100 A/G cg16759221 chr17:45003025 GOSR2 0.45 7.02 0.36 1.31e-11 Orofacial clefts; CRC cis rs9916302 0.706 rs582176 chr17:37453999 T/C cg00129232 chr17:37814104 STARD3 0.57 7.22 0.37 3.66e-12 Glomerular filtration rate (creatinine); CRC trans rs11148252 0.716 rs2760772 chr13:52780373 C/G cg18335740 chr13:41363409 SLC25A15 0.52 7.71 0.39 1.53e-13 Lewy body disease; CRC cis rs9309473 1.000 rs11899902 chr2:73631564 G/A cg20560298 chr2:73613845 ALMS1 -0.47 -5.97 -0.31 6.15e-9 Metabolite levels; CRC cis rs6502050 0.835 rs4459614 chr17:80086597 C/T cg22110888 chr17:80059540 CCDC57 -0.4 -6.17 -0.32 2.06e-9 Life satisfaction; CRC cis rs7474896 0.515 rs594594 chr10:38307723 A/G cg25427524 chr10:38739819 LOC399744 0.64 7.84 0.4 6.18e-14 Obesity (extreme); CRC cis rs9325144 0.532 rs12812406 chr12:38719802 G/A cg26384229 chr12:38710491 ALG10B -0.58 -8.42 -0.42 1.15e-15 Morning vs. evening chronotype; CRC cis rs10256972 0.685 rs10263665 chr7:1110628 A/G cg18402987 chr7:1209562 NA 0.42 6.35 0.33 7e-10 Longevity;Endometriosis; CRC cis rs4332037 0.722 rs60346318 chr7:1915824 C/G cg23422044 chr7:1970798 MAD1L1 -0.59 -7.82 -0.4 7.47e-14 Bipolar disorder; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg00350652 chr1:109584526 WDR47 0.44 7.04 0.36 1.1e-11 Liver disease severity in Alagille syndrome; CRC cis rs72634258 0.945 rs36016881 chr1:8051241 A/G cg00042356 chr1:8021962 PARK7 0.7 7.76 0.39 1.05e-13 Inflammatory bowel disease; CRC cis rs2075371 0.933 rs431306 chr7:133955974 A/T cg02659138 chr7:134003124 SLC35B4 0.35 6.05 0.32 4.05e-9 Mean platelet volume; CRC cis rs2976388 0.967 rs2976395 chr8:143763750 G/A cg22687807 chr8:143858763 LYNX1 -0.37 -6.56 -0.34 2.06e-10 Urinary tract infection frequency; CRC cis rs6912958 0.525 rs586771 chr6:88064971 C/T cg08069147 chr6:88032118 GJB7;C6orf162 0.69 11.34 0.53 2.29e-25 Monocyte percentage of white cells; CRC cis rs1475911 0.708 rs66994219 chr21:43521647 G/A cg24372256 chr21:43528868 UMODL1;C21orf128 -0.67 -10.16 -0.49 2.83e-21 IgG glycosylation; CRC cis rs4332037 0.802 rs12113633 chr7:1932936 G/A cg25834613 chr7:1915315 MAD1L1 -0.46 -6.67 -0.35 1.07e-10 Bipolar disorder; CRC cis rs11971779 0.584 rs6942519 chr7:139070090 A/G cg23387468 chr7:139079360 LUC7L2 0.41 7.04 0.36 1.14e-11 Diisocyanate-induced asthma; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg01668174 chr2:106810661 UXS1 0.46 6.44 0.33 4.25e-10 Response to antipsychotic treatment; CRC cis rs720844 0.684 rs36067597 chr2:149313404 C/G cg09247360 chr2:149335327 NA -0.58 -6.04 -0.32 4.12e-9 Peripheral arterial disease (traffic-related air pollution interaction); CRC trans rs8002861 0.905 rs6561150 chr13:44460470 C/T cg12856521 chr11:46389249 DGKZ 0.43 6.78 0.35 5.59e-11 Leprosy; CRC cis rs7917772 0.582 rs7091252 chr10:104328859 G/T cg11453585 chr10:104263688 ACTR1A;SUFU 0.82 15.26 0.64 3.8e-40 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC cis rs780096 0.546 rs4665976 chr2:27640325 A/G cg24768116 chr2:27665128 KRTCAP3 -0.35 -7.89 -0.4 4.43e-14 Total body bone mineral density; CRC cis rs9427116 0.531 rs35504625 chr1:154599778 C/G cg17218026 chr1:154582156 ADAR 0.67 11.4 0.53 1.39e-25 Blood protein levels; CRC trans rs925098 0.577 rs2724470 chr4:17996046 A/G cg25116269 chr2:55509523 PRDXDD1P -0.43 -6.49 -0.34 3.24e-10 Birth weight;Height; CRC cis rs7786808 0.505 rs67537656 chr7:158192646 C/T cg01191920 chr7:158217561 PTPRN2 0.6 9.61 0.47 1.98e-19 Obesity-related traits; CRC cis rs6815814 0.851 rs11736207 chr4:38766285 G/A cg06935464 chr4:38784597 TLR10 0.57 5.72 0.3 2.44e-8 Breast cancer; CRC cis rs11098499 0.909 rs11723839 chr4:120299673 G/A cg09307838 chr4:120376055 NA 0.7 10.81 0.51 1.69e-23 Corneal astigmatism; CRC cis rs12142240 0.698 rs77185326 chr1:46818417 T/C cg00530320 chr1:46809349 NSUN4 0.58 7.93 0.4 3.43e-14 Menopause (age at onset); CRC cis rs939584 0.935 rs10865551 chr2:641863 T/A cg03610516 chr2:642275 NA 0.42 5.88 0.31 9.94e-9 Body mass index; CRC cis rs3736485 0.966 rs10220909 chr15:51762412 C/A cg08986416 chr15:51914746 DMXL2 -0.41 -5.84 -0.31 1.27e-8 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs6570726 0.902 rs973855 chr6:145781850 C/T cg23711669 chr6:146136114 FBXO30 -0.63 -10.55 -0.5 1.31e-22 Lobe attachment (rater-scored or self-reported); CRC cis rs1949733 0.959 rs2688242 chr4:8429943 T/G cg13073564 chr4:8508604 NA -0.47 -6.95 -0.36 2.01e-11 Response to antineoplastic agents; CRC cis rs7172809 0.897 rs907387 chr15:77828751 T/C cg10437265 chr15:77819839 NA -0.4 -6.75 -0.35 6.52e-11 Glucose homeostasis traits; CRC cis rs763121 0.706 rs3827356 chr22:39064806 G/T cg06022373 chr22:39101656 GTPBP1 -0.72 -11.2 -0.53 6.82e-25 Menopause (age at onset); CRC cis rs1018836 0.608 rs6986165 chr8:91477062 C/G cg16814680 chr8:91681699 NA -0.58 -9.02 -0.45 1.63e-17 Ejection fraction in Tripanosoma cruzi seropositivity; CRC cis rs9443645 0.901 rs9352667 chr6:79572296 A/G cg11833968 chr6:79620685 NA 0.37 6.56 0.34 2.14e-10 Intelligence (multi-trait analysis); CRC cis rs6502050 0.723 rs11650635 chr17:80083816 T/C cg25804541 chr17:80189381 SLC16A3 0.31 5.9 0.31 8.94e-9 Life satisfaction; CRC cis rs4237845 0.742 rs3751330 chr12:58290226 T/C cg02175503 chr12:58329896 NA 0.62 8.84 0.44 5.92e-17 Intelligence (multi-trait analysis); CRC cis rs9372253 0.645 rs7753212 chr6:110700229 T/C cg01119278 chr6:110721349 DDO -0.36 -5.67 -0.3 3.2e-8 Platelet distribution width; CRC cis rs28386778 0.863 rs11649912 chr17:61797515 T/A cg06873352 chr17:61820015 STRADA 0.76 14.32 0.62 1.69e-36 Prudent dietary pattern; CRC cis rs12024301 0.557 rs12047865 chr1:183615929 A/G cg11505048 chr1:183622726 RGL1;APOBEC4 0.81 7.0 0.36 1.42e-11 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs13191362 0.507 rs2849511 chr6:163139050 C/G cg21926612 chr6:163149169 PACRG;PARK2 -0.65 -10.17 -0.49 2.68e-21 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs7927592 0.763 rs10896351 chr11:68386896 G/A cg16797656 chr11:68205561 LRP5 0.49 8.88 0.44 4.54e-17 Total body bone mineral density; CRC cis rs72615157 0.645 rs76281814 chr7:99846414 T/C cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.47 5.63 0.3 3.88e-8 Lung function (FEV1/FVC); CRC cis rs2404602 0.716 rs12902174 chr15:76863540 T/C cg22467129 chr15:76604101 ETFA -0.39 -6.43 -0.33 4.59e-10 Blood metabolite levels; CRC cis rs11098499 0.779 rs28495013 chr4:120375831 A/C cg24375607 chr4:120327624 NA 0.51 7.98 0.4 2.49e-14 Corneal astigmatism; CRC cis rs2243480 1.000 rs60683927 chr7:65394768 T/C cg18252515 chr7:66147081 NA -1.08 -12.66 -0.57 3.44e-30 Diabetic kidney disease; CRC cis rs7618915 0.501 rs6804145 chr3:52694198 C/T cg05573699 chr3:52720067 GNL3;PBRM1 -0.48 -7.01 -0.36 1.36e-11 Bipolar disorder; CRC cis rs433852 0.718 rs386551 chr19:49138286 C/G cg06677660 chr19:49140777 SEC1;DBP -0.46 -5.86 -0.31 1.1e-8 Elevated serum carcinoembryonic antigen levels;Posterior cortical atrophy and Alzheimer's disease; CRC cis rs12936587 0.601 rs11655881 chr17:17553133 G/A cg09796270 chr17:17721594 SREBF1 -0.45 -7.63 -0.39 2.47e-13 Hip circumference;Coronary artery disease or large artery stroke;Coronary heart disease;Coronary artery disease; CRC cis rs2046867 0.818 rs1502754 chr3:72895345 G/T cg25664220 chr3:72788482 NA -0.41 -6.23 -0.32 1.43e-9 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; CRC cis rs1699337 0.538 rs66615477 chr3:12298314 G/T cg04748988 chr3:12329223 PPARG -0.4 -5.95 -0.31 6.91e-9 Cholesterol, total; CRC cis rs9611565 0.765 rs9607800 chr22:41784562 A/G cg06634786 chr22:41940651 POLR3H -0.66 -7.69 -0.39 1.7e-13 Vitiligo; CRC cis rs8177253 1.000 rs1525892 chr3:133484712 C/T cg11941060 chr3:133502564 NA -0.59 -10.26 -0.49 1.26e-21 Iron status biomarkers; CRC cis rs763121 0.776 rs4820346 chr22:39125074 C/G cg06544989 chr22:39130855 UNC84B -0.44 -6.61 -0.34 1.56e-10 Menopause (age at onset); CRC cis rs2952156 0.920 rs2934953 chr17:37832315 T/A cg00129232 chr17:37814104 STARD3 -0.69 -11.53 -0.54 4.72e-26 Asthma; CRC cis rs4713118 0.513 rs9368547 chr6:28028067 A/G cg02683197 chr6:28174875 NA 0.63 8.49 0.42 7.22e-16 Parkinson's disease; CRC cis rs990171 0.802 rs1558650 chr2:103060024 T/A cg03938978 chr2:103052716 IL18RAP 0.46 5.91 0.31 8.41e-9 Lymphocyte counts; CRC cis rs853679 0.517 rs9295759 chr6:28124469 C/T cg12273811 chr6:28175739 NA 0.73 9.16 0.45 5.8e-18 Depression; CRC cis rs8078723 0.714 rs3785550 chr17:38149727 C/T cg17344932 chr17:38183730 MED24;SNORD124 0.48 7.98 0.4 2.38e-14 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); CRC cis rs1448094 0.512 rs6539932 chr12:86247497 T/C cg02569458 chr12:86230093 RASSF9 0.42 7.14 0.37 6.15e-12 Major depressive disorder; CRC trans rs66573146 1.000 rs55672215 chr4:6970529 T/C cg07817883 chr1:32538562 TMEM39B 1.34 12.82 0.58 8.63e-31 Granulocyte percentage of myeloid white cells; CRC cis rs798554 0.704 rs798503 chr7:2789704 G/A cg04166393 chr7:2884313 GNA12 0.39 6.05 0.32 3.97e-9 Height; CRC cis rs5769765 0.646 rs9627789 chr22:50300562 A/G cg04121214 chr22:50244548 NA 0.41 5.87 0.31 1.04e-8 Schizophrenia; CRC cis rs11122272 0.735 rs2572263 chr1:231509408 C/T cg06096015 chr1:231504339 EGLN1 0.4 5.95 0.31 6.7e-9 Hemoglobin concentration; CRC cis rs7772486 0.790 rs9497435 chr6:146265340 C/A cg23711669 chr6:146136114 FBXO30 -0.65 -11.14 -0.52 1.1e-24 Lobe attachment (rater-scored or self-reported); CRC cis rs3857067 0.806 rs9996975 chr4:95101338 C/G cg11021082 chr4:95130006 SMARCAD1 -0.49 -7.53 -0.38 4.88e-13 QT interval; CRC cis rs6951245 1.000 rs113066613 chr7:1094128 T/C cg18402987 chr7:1209562 NA 0.67 7.26 0.37 2.83e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs3749237 1.000 rs11920900 chr3:49823024 G/C cg24308560 chr3:49941425 MST1R -0.42 -5.93 -0.31 7.5e-9 Resting heart rate; CRC cis rs1395 0.744 rs62130709 chr2:27505782 C/T cg14242246 chr2:27434262 C2orf28;SLC5A6 0.35 5.83 0.31 1.3e-8 Blood metabolite levels; CRC cis rs3087591 1.000 rs7216033 chr17:29574642 A/G cg24425628 chr17:29625626 OMG;NF1 -0.84 -16.52 -0.67 4.36e-45 Hip circumference; CRC cis rs1552244 1.000 rs9811771 chr3:10133949 A/G cg08888203 chr3:10149979 C3orf24 0.67 9.49 0.46 4.83e-19 Alzheimer's disease; CRC cis rs11030122 0.547 rs10767721 chr11:3953411 G/C cg18678763 chr11:4115507 RRM1 -0.39 -6.61 -0.34 1.59e-10 Mean platelet volume;Platelet distribution width; CRC cis rs11758351 0.660 rs11755943 chr6:26211368 A/G cg08260959 chr6:26240920 HIST1H4F -0.36 -5.98 -0.31 5.81e-9 Gout;Renal underexcretion gout; CRC cis rs6951245 0.935 rs11763765 chr7:1060510 C/T cg22907277 chr7:1156413 C7orf50 0.69 7.18 0.37 4.6e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs2811415 0.627 rs13316354 chr3:127751772 A/G cg13719885 chr3:127795394 NA -0.37 -5.67 -0.3 3.19e-8 Lung function (FEV1/FVC); CRC cis rs73206853 0.563 rs1973505 chr12:111160003 A/G cg12870014 chr12:110450643 ANKRD13A -0.82 -11.64 -0.54 1.88e-26 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC cis rs77106637 1.000 rs3862791 chr11:72501002 C/T cg03713592 chr11:72463424 ARAP1 0.91 8.62 0.43 2.79e-16 Type 2 diabetes; CRC cis rs57221529 1.000 rs57221529 chr5:586624 A/G cg14541582 chr5:601475 NA -0.35 -6.98 -0.36 1.63e-11 Lung disease severity in cystic fibrosis; CRC cis rs2624839 0.629 rs2526397 chr3:50187790 A/C cg05623727 chr3:50126028 RBM5 -0.41 -6.29 -0.33 9.9e-10 Intelligence (multi-trait analysis); CRC cis rs3741404 0.594 rs11231704 chr11:63898182 C/T cg18225595 chr11:63971243 STIP1 -0.42 -6.5 -0.34 3.07e-10 Platelet count; CRC cis rs1552244 1.000 rs6768102 chr3:10149380 A/G cg18598329 chr3:10140678 FANCD2;C3orf24 -0.86 -11.48 -0.53 6.79e-26 Alzheimer's disease; CRC cis rs28386778 0.897 rs8077013 chr17:61850392 C/T cg11494091 chr17:61959527 GH2 0.63 10.73 0.51 3.01e-23 Prudent dietary pattern; CRC trans rs561341 1.000 rs555629 chr17:30294136 T/C cg27661571 chr11:113659931 NA -0.95 -11.08 -0.52 1.91e-24 Hip circumference adjusted for BMI; CRC cis rs9467711 0.606 rs9379859 chr6:26369549 C/T cg16898833 chr6:26189333 HIST1H4D 0.76 6.58 0.34 1.88e-10 Autism spectrum disorder or schizophrenia; CRC cis rs939658 0.805 rs2010524 chr15:79435825 G/T cg17916960 chr15:79447300 NA -0.45 -7.38 -0.38 1.27e-12 Refractive error; CRC cis rs2075371 0.933 rs2544191 chr7:133954248 A/G cg20476274 chr7:133979776 SLC35B4 0.78 14.1 0.61 1.18e-35 Mean platelet volume; CRC cis rs11148252 0.595 rs4885325 chr13:53171317 C/T cg02158880 chr13:53174818 NA 0.55 8.83 0.44 6.47e-17 Lewy body disease; CRC cis rs950027 0.620 rs2467862 chr15:45643843 T/G cg21132104 chr15:45694354 SPATA5L1 0.42 6.06 0.32 3.76e-9 Response to fenofibrate (adiponectin levels); CRC trans rs1728785 1.000 rs7202306 chr16:68587684 G/A cg04657470 chr2:198365150 HSPE1;HSPD1 0.58 7.05 0.36 1.08e-11 Ulcerative colitis; CRC trans rs11026407 0.967 rs7127246 chr11:22060228 C/G cg00224911 chr4:74486142 RASSF6 -0.55 -6.51 -0.34 2.8e-10 Plasma thyroid-stimulating hormone levels; CRC cis rs896854 0.902 rs896852 chr8:95960886 G/T cg23172400 chr8:95962367 TP53INP1 -0.48 -7.96 -0.4 2.88e-14 Type 2 diabetes; CRC cis rs4665809 0.887 rs4665814 chr2:26273687 G/T cg27170947 chr2:26402098 FAM59B -0.44 -6.0 -0.31 5.09e-9 Gut microbiome composition (summer); CRC cis rs734999 0.545 rs10797441 chr1:2551660 T/G cg18854424 chr1:2615690 NA 0.39 7.42 0.38 1.03e-12 Ulcerative colitis; CRC cis rs13427251 0.868 rs1901284 chr2:100146040 A/G cg26064155 chr2:99771622 LIPT1;TSGA10 0.51 7.45 0.38 8.05e-13 Chronic sinus infection; CRC cis rs57221529 0.766 rs12522303 chr5:555564 A/C cg14541582 chr5:601475 NA -0.33 -6.6 -0.34 1.61e-10 Lung disease severity in cystic fibrosis; CRC cis rs3091242 0.933 rs35530120 chr1:25785451 A/G cg27572855 chr1:25598939 RHD -0.35 -6.09 -0.32 3.24e-9 Erythrocyte sedimentation rate; CRC cis rs10857712 0.754 rs2297033 chr10:135234848 C/T cg19904058 chr10:135279010 LOC619207 -0.35 -6.78 -0.35 5.56e-11 Systemic lupus erythematosus; CRC cis rs11997175 0.603 rs7001603 chr8:33680978 T/G cg04338863 chr8:33670619 NA 0.44 6.96 0.36 1.8e-11 Body mass index; CRC cis rs7605827 0.897 rs11684844 chr2:15640552 T/A cg19274914 chr2:15703543 NA 0.4 6.05 0.32 4e-9 Educational attainment (years of education); CRC cis rs1881797 1.000 rs68059491 chr1:247683070 C/T cg05639522 chr1:247681581 NA 0.5 7.3 0.37 2.18e-12 Acute lymphoblastic leukemia (childhood); CRC cis rs11212617 1.000 rs2356801 chr11:108281999 G/A cg14761454 chr11:108092087 ATM;NPAT 0.43 6.4 0.33 5.31e-10 Response to metformin in type 2 diabetes (glycemic); CRC cis rs262150 0.644 rs2730228 chr7:158789361 T/C cg12590608 chr7:158785262 NA 0.37 6.4 0.33 5.45e-10 Facial morphology (factor 20); CRC cis rs4478858 0.698 rs6669381 chr1:31833506 A/G cg00250761 chr1:31883323 NA -0.44 -8.46 -0.42 8.64e-16 Alcohol dependence; CRC cis rs9916302 0.706 rs8078599 chr17:37518660 C/T cg07936489 chr17:37558343 FBXL20 0.86 10.19 0.49 2.18e-21 Glomerular filtration rate (creatinine); CRC cis rs1707322 1.000 rs4641257 chr1:46353589 G/A cg06784218 chr1:46089804 CCDC17 0.52 9.12 0.45 7.89e-18 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs6665290 0.904 rs2297415 chr1:227172903 G/A cg10327440 chr1:227177885 CDC42BPA -1.04 -23.27 -0.79 1.67e-71 Myeloid white cell count; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg09916155 chr16:1728187 HN1L 0.47 6.26 0.33 1.2e-9 Anxiety disorder; CRC cis rs17376456 0.825 rs6877030 chr5:93201841 C/A cg25358565 chr5:93447407 FAM172A 1.06 10.36 0.5 5.88e-22 Diabetic retinopathy; CRC cis rs3857067 0.680 rs1509946 chr4:95109078 G/T cg11021082 chr4:95130006 SMARCAD1 -0.48 -7.5 -0.38 5.93e-13 QT interval; CRC cis rs6918586 0.658 rs1572982 chr6:26094367 G/A cg18357526 chr6:26021779 HIST1H4A 0.49 7.43 0.38 9.17e-13 Schizophrenia; CRC cis rs394563 0.967 rs369643 chr6:149799798 A/G cg11245181 chr6:149772854 ZC3H12D -0.52 -8.74 -0.43 1.24e-16 Dupuytren's disease; CRC cis rs2836974 0.666 rs2836975 chr21:40663620 A/G cg22974920 chr21:40686053 BRWD1 -0.42 -5.9 -0.31 8.87e-9 Cognitive function; CRC cis rs9322817 0.691 rs9391241 chr6:105223663 T/C cg02098413 chr6:105308735 HACE1 -0.44 -8.51 -0.42 6.41e-16 Thyroid stimulating hormone; CRC cis rs7666738 0.830 rs10007261 chr4:98926155 C/T cg05340658 chr4:99064831 C4orf37 0.6 9.35 0.46 1.41e-18 Colonoscopy-negative controls vs population controls; CRC cis rs7020830 0.830 rs13296413 chr9:37258105 C/T cg14294708 chr9:37120828 ZCCHC7 1.14 22.95 0.78 2.88e-70 Schizophrenia; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg02439053 chr19:18390991 JUND 0.39 6.13 0.32 2.5e-9 Liver disease severity in Alagille syndrome; CRC cis rs17376456 0.809 rs12152763 chr5:93405509 T/A cg21475434 chr5:93447410 FAM172A 0.74 7.58 0.39 3.47e-13 Diabetic retinopathy; CRC cis rs3806843 0.741 rs2563293 chr5:140110536 T/C cg19875535 chr5:140030758 IK -0.63 -10.27 -0.49 1.2e-21 Depressive symptoms (multi-trait analysis); CRC cis rs9368481 0.672 rs3931463 chr6:26939797 G/A cg18278486 chr6:26987575 LOC100270746;C6orf41 0.41 6.42 0.33 4.82e-10 Autism spectrum disorder or schizophrenia; CRC cis rs17376456 0.569 rs11948511 chr5:93286601 A/C cg25358565 chr5:93447407 FAM172A -0.56 -7.62 -0.39 2.75e-13 Diabetic retinopathy; CRC cis rs13315871 1.000 rs9849482 chr3:58422087 G/T cg20936604 chr3:58311152 NA -0.76 -7.15 -0.37 5.74e-12 Cholesterol, total; CRC cis rs11098699 0.769 rs11726870 chr4:124229175 A/G cg09941581 chr4:124220074 SPATA5 0.39 5.81 0.3 1.49e-8 Mosquito bite size; CRC cis rs9916302 0.861 rs33933929 chr17:37426441 A/C cg03013999 chr17:37608204 MED1 0.48 7.35 0.38 1.59e-12 Glomerular filtration rate (creatinine); CRC cis rs7546094 0.967 rs1032312 chr1:113112746 G/A cg22162597 chr1:113214053 CAPZA1 0.43 5.94 0.31 7.2e-9 Platelet distribution width; CRC cis rs8058578 1.000 rs6565201 chr16:30747191 C/T cg00531865 chr16:30841666 NA -0.47 -6.57 -0.34 1.99e-10 Multiple myeloma; CRC cis rs3736485 0.966 rs8041514 chr15:51866054 T/C cg08986416 chr15:51914746 DMXL2 -0.45 -6.56 -0.34 2.12e-10 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC trans rs7618501 0.602 rs2526743 chr3:50115245 G/A cg21659725 chr3:3221576 CRBN -0.55 -8.7 -0.43 1.64e-16 Intelligence (multi-trait analysis); CRC cis rs2067615 0.560 rs1882542 chr12:107070049 A/C cg13491945 chr12:107078410 RFX4 0.34 5.86 0.31 1.1e-8 Heart rate; CRC cis rs651907 0.535 rs34263427 chr3:101507805 A/G cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.59 7.86 0.4 5.62e-14 Colorectal cancer; CRC cis rs11640734 0.609 rs11647746 chr16:89806343 C/A cg19635926 chr16:89946313 TCF25 0.66 6.84 0.35 3.9e-11 Interleukin-17 levels; CRC cis rs9443645 0.901 rs1984195 chr6:79657391 G/A cg05283184 chr6:79620031 NA -0.58 -9.21 -0.45 3.9e-18 Intelligence (multi-trait analysis); CRC cis rs17767392 0.813 rs34991781 chr14:71921576 G/A cg13720639 chr14:72061746 SIPA1L1 -0.5 -6.42 -0.33 4.81e-10 Mitral valve prolapse; CRC cis rs7267979 0.844 rs6050477 chr20:25221547 C/T cg13962466 chr20:25176127 ENTPD6 -0.42 -6.66 -0.34 1.16e-10 Liver enzyme levels (alkaline phosphatase); CRC cis rs6502050 0.835 rs34287733 chr17:80078236 C/T cg02741985 chr17:80059408 CCDC57 -0.44 -7.16 -0.37 5.33e-12 Life satisfaction; CRC cis rs2032447 0.714 rs175319 chr6:25956172 A/G cg03264133 chr6:25882463 NA -0.6 -8.37 -0.42 1.64e-15 Intelligence (multi-trait analysis); CRC cis rs7493 0.950 rs7785705 chr7:95033803 A/T cg04871131 chr7:94954202 PON1 -0.46 -5.61 -0.3 4.23e-8 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs1322512 0.959 rs2623985 chr6:152948748 T/C cg03415253 chr6:152958462 SYNE1 -0.42 -6.43 -0.33 4.53e-10 Tonometry; CRC cis rs1062753 0.922 rs9611712 chr22:42410993 T/C cg00645731 chr22:42541494 CYP2D7P1 0.4 6.94 0.36 2.1e-11 Response to serotonin reuptake inhibitors in major depressive disorder (plasma drug and metabolite levels); CRC cis rs250677 0.958 rs10056942 chr5:148416114 C/A cg23229984 chr5:148520753 ABLIM3 0.48 6.64 0.34 1.33e-10 Breast cancer; CRC cis rs853679 1.000 rs6901575 chr6:28250984 G/A cg06470822 chr6:28175283 NA 0.68 6.8 0.35 4.98e-11 Depression; CRC cis rs11212617 0.967 rs227053 chr11:108226855 A/T cg14761454 chr11:108092087 ATM;NPAT 0.42 6.16 0.32 2.08e-9 Response to metformin in type 2 diabetes (glycemic); CRC cis rs2188554 0.711 rs213947 chr7:117192608 A/G cg09181792 chr7:117119393 CFTR 0.33 6.07 0.32 3.49e-9 Esophageal adenocarcinoma; CRC cis rs9443645 0.838 rs9350800 chr6:79729489 A/C cg11833968 chr6:79620685 NA -0.36 -6.12 -0.32 2.65e-9 Intelligence (multi-trait analysis); CRC cis rs4964805 0.913 rs7134701 chr12:104202691 C/T cg02344784 chr12:104178138 NT5DC3 0.53 7.79 0.39 8.84e-14 Attention deficit hyperactivity disorder; CRC cis rs6860806 0.661 rs3763112 chr5:131586480 A/G cg11843238 chr5:131593191 PDLIM4 0.41 7.79 0.39 9.14e-14 Breast cancer; CRC cis rs56283067 0.847 rs12198153 chr6:44691878 T/C cg18551225 chr6:44695536 NA -0.41 -5.92 -0.31 8.07e-9 Total body bone mineral density; CRC cis rs7591163 0.883 rs11891398 chr2:228723357 C/T cg20647610 chr2:228736258 WDR69 -0.47 -6.45 -0.33 4.09e-10 Blood pressure; CRC cis rs853679 0.517 rs11552219 chr6:28126834 C/T cg12963246 chr6:28129442 ZNF389 0.49 5.7 0.3 2.71e-8 Depression; CRC cis rs4713118 0.591 rs2056924 chr6:27690174 G/A cg12172441 chr6:28176163 NA 0.46 6.44 0.33 4.21e-10 Parkinson's disease; CRC cis rs4711336 1.000 rs4711336 chr6:33659046 A/G cg14003231 chr6:33640908 ITPR3 -0.49 -7.93 -0.4 3.52e-14 Height; CRC cis rs9527 0.545 rs7100369 chr10:104956218 C/A cg04362960 chr10:104952993 NT5C2 0.61 8.51 0.42 6.45e-16 Arsenic metabolism; CRC cis rs3736485 0.652 rs2054166 chr15:51974910 A/T cg08986416 chr15:51914746 DMXL2 -0.45 -6.32 -0.33 8.73e-10 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs9916302 0.904 rs68178216 chr17:37526241 A/C cg03013999 chr17:37608204 MED1 -0.46 -6.95 -0.36 1.97e-11 Glomerular filtration rate (creatinine); CRC cis rs12497850 0.897 rs7373778 chr3:48836392 C/G cg07636037 chr3:49044803 WDR6 1.04 18.54 0.71 4.71e-53 Parkinson's disease; CRC cis rs4862750 0.872 rs6811837 chr4:187898162 G/A cg07414643 chr4:187882934 NA 0.39 6.87 0.35 3.27e-11 Lobe attachment (rater-scored or self-reported); CRC cis rs904251 0.861 rs1757171 chr6:37487044 T/C cg25019722 chr6:37503610 NA -0.51 -9.55 -0.47 3.13e-19 Cognitive performance; CRC cis rs4862750 0.957 rs6858853 chr4:187903412 A/C cg10295955 chr4:187884368 NA 1.02 24.01 0.8 2.59e-74 Lobe attachment (rater-scored or self-reported); CRC cis rs4689388 0.816 rs13147655 chr4:6293474 A/G cg25554036 chr4:6271136 WFS1 0.53 8.72 0.43 1.42e-16 Type 2 diabetes and other traits;Type 2 diabetes; CRC cis rs17376456 0.542 rs2084916 chr5:93194961 A/T cg09848695 chr5:92956644 FAM172A;MIR2277 -0.53 -5.97 -0.31 6.21e-9 Diabetic retinopathy; CRC cis rs12188164 0.582 rs80273890 chr5:483057 C/T cg21625146 chr5:486483 SLC9A3 -0.48 -5.71 -0.3 2.55e-8 Cystic fibrosis severity; CRC cis rs2180341 1.000 rs3798852 chr6:127636733 A/G cg27446573 chr6:127587934 RNF146 0.98 14.44 0.62 6.21e-37 Breast cancer; CRC cis rs12155623 0.932 rs34236473 chr8:49828725 A/T cg22283653 chr8:49824208 NA 0.36 5.73 0.3 2.29e-8 Sudden cardiac arrest; CRC cis rs4711350 0.906 rs3957165 chr6:33784864 A/G cg07979401 chr6:33739406 LEMD2 0.49 6.18 0.32 1.85e-9 Schizophrenia; CRC cis rs1943345 0.686 rs10898088 chr11:82874970 G/A cg07047830 chr11:82868014 PCF11 0.42 6.03 0.32 4.33e-9 Obesity-related traits; CRC cis rs6500395 0.963 rs12919278 chr16:48692537 A/G cg04672837 chr16:48644449 N4BP1 -0.45 -6.63 -0.34 1.38e-10 Response to tocilizumab in rheumatoid arthritis; CRC cis rs853679 0.517 rs9393890 chr6:28063855 C/T cg06470822 chr6:28175283 NA 1.0 13.33 0.59 1.04e-32 Depression; CRC cis rs6582630 0.572 rs7315897 chr12:38449081 C/T cg26384229 chr12:38710491 ALG10B -0.55 -7.87 -0.4 5.11e-14 Drug-induced liver injury (flucloxacillin); CRC cis rs10992471 0.580 rs7852698 chr9:95396409 C/T cg14631576 chr9:95140430 CENPP -0.33 -5.64 -0.3 3.62e-8 Visceral adipose tissue/subcutaneous adipose tissue ratio; CRC cis rs6088590 0.735 rs2273684 chr20:33529766 G/T cg08999081 chr20:33150536 PIGU -0.44 -7.45 -0.38 8.47e-13 Coronary artery disease; CRC cis rs9858542 1.000 rs11709525 chr3:49690496 C/T cg03060546 chr3:49711283 APEH -0.51 -6.86 -0.35 3.36e-11 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs2439831 0.850 rs3736180 chr15:44106624 A/G cg02155558 chr15:43621948 ADAL;LCMT2 0.7 7.69 0.39 1.68e-13 Lung cancer in ever smokers; CRC cis rs9457247 0.565 rs2239824 chr6:167511799 T/A cg07513332 chr6:167530253 CCR6 0.36 5.68 0.3 2.94e-8 Crohn's disease; CRC trans rs1814175 0.817 rs4405313 chr11:50013636 G/A cg15704280 chr7:45808275 SEPT13 -0.99 -20.61 -0.75 3.6e-61 Height; CRC cis rs7725052 0.720 rs10073277 chr5:40488686 A/G cg09067459 chr5:40385259 NA 0.37 5.97 0.31 6.31e-9 Pediatric autoimmune diseases; CRC cis rs6952808 0.723 rs55689856 chr7:2037215 G/A cg02951883 chr7:2050386 MAD1L1 -0.77 -12.7 -0.57 2.37e-30 Bipolar disorder and schizophrenia; CRC cis rs6496044 0.568 rs6496040 chr15:86064129 C/G cg17133734 chr15:86042851 AKAP13 0.41 6.73 0.35 7.47e-11 Interstitial lung disease; CRC cis rs28830936 1.000 rs2577960 chr15:42028354 C/A cg17847044 chr15:42102381 MAPKBP1 0.3 6.39 0.33 5.52e-10 Diastolic blood pressure; CRC cis rs1865760 0.623 rs12216125 chr6:25997458 C/T cg17691542 chr6:26056736 HIST1H1C 0.6 8.6 0.43 3.39e-16 Height; CRC cis rs9910055 0.529 rs228767 chr17:42188311 C/G cg19774624 chr17:42201019 HDAC5 0.52 6.96 0.36 1.89e-11 Total body bone mineral density; CRC cis rs1881797 0.527 rs1852908 chr1:247678260 C/T cg05639522 chr1:247681581 NA 0.56 6.07 0.32 3.48e-9 Acute lymphoblastic leukemia (childhood); CRC cis rs853679 0.517 rs3757187 chr6:28107654 T/C cg18032046 chr6:28092343 ZSCAN16 -0.52 -6.08 -0.32 3.3e-9 Depression; CRC cis rs3892630 0.824 rs7247264 chr19:33239846 T/G cg22980127 chr19:33182716 NUDT19 0.92 11.22 0.53 6.11e-25 Red blood cell traits; CRC cis rs4664293 0.647 rs7580539 chr2:160445749 C/T cg08347373 chr2:160653686 CD302 -0.38 -6.44 -0.33 4.12e-10 Monocyte percentage of white cells; CRC cis rs9905704 0.624 rs34718875 chr17:57072461 G/A cg12560992 chr17:57184187 TRIM37 0.67 10.42 0.5 3.7e-22 Testicular germ cell tumor; CRC cis rs68170813 0.641 rs79328953 chr7:106901557 C/T cg02696742 chr7:106810147 HBP1 -0.62 -6.96 -0.36 1.87e-11 Coronary artery disease; CRC cis rs1983891 0.955 rs9381076 chr6:41517564 G/A cg20194872 chr6:41519635 FOXP4 0.4 5.86 0.31 1.12e-8 Prostate cancer; CRC cis rs972578 0.837 rs5996246 chr22:43297421 A/T cg01576275 chr22:43409880 NA -0.44 -6.91 -0.36 2.48e-11 Mean platelet volume; CRC cis rs9527 0.545 rs12784384 chr10:104957594 G/C cg15744005 chr10:104629667 AS3MT -0.29 -5.76 -0.3 1.92e-8 Arsenic metabolism; CRC cis rs7089973 0.604 rs10490909 chr10:116593532 C/T cg23260525 chr10:116636907 FAM160B1 0.35 8.01 0.4 1.95e-14 Bipolar disorder or attention deficit hyperactivity disorder; CRC cis rs3820068 0.603 rs7516453 chr1:15972558 C/G cg24675056 chr1:15929824 NA 0.54 7.0 0.36 1.44e-11 Systolic blood pressure; CRC cis rs1150668 0.699 rs1736895 chr6:28219826 G/A cg21251018 chr6:28226885 NKAPL 0.63 11.77 0.54 6.06e-27 Pubertal anthropometrics; CRC cis rs1843834 0.505 rs7585047 chr2:225373897 C/T cg22509189 chr2:225307070 NA -0.38 -5.76 -0.3 1.89e-8 IgE levels in asthmatics (D.p. specific); CRC cis rs6748734 0.857 rs4675857 chr2:241842326 T/C cg16358738 chr2:241808595 AGXT -0.41 -6.09 -0.32 3.22e-9 Urinary metabolites; CRC cis rs4665809 0.627 rs13032756 chr2:26489730 A/T cg26119090 chr2:26468346 HADHA;HADHB 0.99 14.15 0.62 7.96e-36 Gut microbiome composition (summer); CRC cis rs731174 0.797 rs670692 chr1:38148124 G/A cg06917450 chr1:38156652 C1orf109 -0.52 -7.23 -0.37 3.42e-12 Prostate cancer (SNP x SNP interaction); CRC cis rs2120019 0.938 rs2289582 chr15:75310394 T/C cg17294928 chr15:75287854 SCAMP5 -0.8 -11.5 -0.54 6e-26 Blood trace element (Zn levels); CRC trans rs875971 0.660 rs2191268 chr7:66110224 C/T cg00042657 chr1:171753628 METTL13 0.37 6.44 0.33 4.12e-10 Aortic root size; CRC cis rs11792861 0.591 rs10979632 chr9:111732140 G/C cg14432460 chr9:111696404 IKBKAP;C9orf6 0.52 7.49 0.38 6.23e-13 Menarche (age at onset); CRC cis rs801193 0.569 rs881285 chr7:66119420 A/G cg00343986 chr7:65444356 GUSB -0.45 -6.2 -0.32 1.7e-9 Aortic root size; CRC cis rs1552244 0.808 rs17032306 chr3:10091399 C/G cg02579736 chr3:10068473 FANCD2;CIDECP 0.97 13.13 0.59 6.13e-32 Alzheimer's disease; CRC cis rs3087591 0.659 rs757377 chr17:29720426 G/A cg24425628 chr17:29625626 OMG;NF1 0.74 13.38 0.59 6.49e-33 Hip circumference; CRC cis rs6460942 0.915 rs62447638 chr7:12484667 G/A cg06484146 chr7:12443880 VWDE -0.77 -7.99 -0.4 2.25e-14 Coronary artery disease; CRC cis rs4332037 0.901 rs7791899 chr7:1935988 T/C cg23378565 chr7:2036160 MAD1L1 -0.46 -6.65 -0.34 1.19e-10 Bipolar disorder; CRC cis rs7412746 0.597 rs868751 chr1:150669414 T/G cg10589385 chr1:150898437 SETDB1 0.3 6.42 0.33 4.78e-10 Melanoma; CRC cis rs6860806 0.507 rs272878 chr5:131671769 C/T cg22638593 chr5:131593259 PDLIM4 -0.37 -6.29 -0.33 1.03e-9 Breast cancer; CRC cis rs6456156 0.586 rs2345753 chr6:167484344 T/A cg07741184 chr6:167504864 NA 0.38 6.65 0.34 1.21e-10 Primary biliary cholangitis; CRC cis rs7615952 0.599 rs2279821 chr3:125734308 G/A cg05084668 chr3:125655381 ALG1L -0.46 -6.35 -0.33 7.32e-10 Blood pressure (smoking interaction); CRC cis rs67340775 0.541 rs200974 chr6:27855845 A/G cg08798685 chr6:27730294 NA -0.57 -6.29 -0.33 9.95e-10 Lung cancer in ever smokers; CRC cis rs4862750 0.872 rs10027252 chr4:187873462 T/G cg06074448 chr4:187884817 NA -0.59 -10.66 -0.51 5.47e-23 Lobe attachment (rater-scored or self-reported); CRC cis rs11098499 0.604 rs2389882 chr4:120566733 A/C cg09307838 chr4:120376055 NA 0.64 9.36 0.46 1.28e-18 Corneal astigmatism; CRC cis rs4664293 0.836 rs4665118 chr2:160659449 G/T cg08347373 chr2:160653686 CD302 -0.41 -6.31 -0.33 9.13e-10 Monocyte percentage of white cells; CRC cis rs2228479 0.850 rs17233567 chr16:89813821 G/A cg19635926 chr16:89946313 TCF25 0.66 5.97 0.31 6.1e-9 Skin colour saturation; CRC cis rs2404602 0.583 rs12913096 chr15:76551852 C/T cg00316803 chr15:76480434 C15orf27 -0.4 -6.8 -0.35 5.02e-11 Blood metabolite levels; CRC cis rs4713118 0.515 rs9368549 chr6:28050047 T/A cg15786705 chr6:28176104 NA 0.74 9.57 0.47 2.68e-19 Parkinson's disease; CRC cis rs4665809 0.549 rs7577896 chr2:26524493 C/T cg25036284 chr2:26402008 FAM59B 0.66 7.79 0.39 8.85e-14 Gut microbiome composition (summer); CRC cis rs4665809 1.000 rs13030858 chr2:26315451 G/A cg27170947 chr2:26402098 FAM59B -0.45 -6.06 -0.32 3.68e-9 Gut microbiome composition (summer); CRC cis rs10504229 1.000 rs67895971 chr8:58177994 A/G cg02290350 chr8:58132656 NA -0.42 -5.96 -0.31 6.62e-9 Developmental language disorder (linguistic errors); CRC cis rs9443645 0.527 rs9352663 chr6:79558164 T/C cg05283184 chr6:79620031 NA -0.43 -6.34 -0.33 7.38e-10 Intelligence (multi-trait analysis); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg26918957 chr8:22926800 TNFRSF10B 0.4 6.05 0.32 3.89e-9 Intelligence (multi-trait analysis); CRC trans rs208520 0.690 rs851467 chr6:66802721 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.07 -15.42 -0.65 9.24e-41 Exhaled nitric oxide output; CRC trans rs2243480 1.000 rs2420171 chr7:65637760 T/C cg10756647 chr7:56101905 PSPH -0.76 -7.87 -0.4 5.31e-14 Diabetic kidney disease; CRC cis rs4481887 0.893 rs10888347 chr1:248448566 T/C cg13385794 chr1:248469461 NA 0.36 6.27 0.33 1.14e-9 Common traits (Other); CRC cis rs6951245 1.000 rs79327308 chr7:1108141 A/C cg20603222 chr7:1096387 C7orf50;GPR146 -0.73 -8.68 -0.43 1.92e-16 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs4969178 0.895 rs2292640 chr17:76396610 G/A cg20026190 chr17:76395443 PGS1 0.4 6.2 0.32 1.73e-9 HDL cholesterol levels; CRC cis rs4555082 0.834 rs2735822 chr14:105712734 C/T cg06808227 chr14:105710500 BRF1 -0.6 -8.58 -0.43 3.77e-16 Mean platelet volume;Platelet distribution width; CRC cis rs9467711 0.591 rs6913795 chr6:25848025 T/C cg08501292 chr6:25962987 TRIM38 1.15 9.94 0.48 1.63e-20 Autism spectrum disorder or schizophrenia; CRC cis rs7927592 0.956 rs11228277 chr11:68308324 G/A cg16797656 chr11:68205561 LRP5 0.4 6.7 0.35 9.18e-11 Total body bone mineral density; CRC cis rs8072100 0.713 rs3871595 chr17:45511388 C/T cg08085267 chr17:45401833 C17orf57 -0.57 -8.61 -0.43 3.04e-16 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs67478160 0.643 rs8004408 chr14:104203938 G/A cg08213375 chr14:104286397 PPP1R13B 0.64 13.18 0.59 3.67e-32 Schizophrenia; CRC cis rs9902453 0.845 rs7501472 chr17:28010628 T/G cg26525008 chr17:28256777 EFCAB5;SSH2 0.6 9.03 0.45 1.46e-17 Coffee consumption (cups per day); CRC cis rs9467711 0.659 rs34246779 chr6:26549212 G/A cg08501292 chr6:25962987 TRIM38 0.88 6.11 0.32 2.84e-9 Autism spectrum disorder or schizophrenia; CRC cis rs62458065 0.513 rs9655340 chr7:32535920 A/G cg20159608 chr7:32802032 NA 0.63 8.1 0.41 1.1e-14 Metabolite levels (HVA/MHPG ratio); CRC cis rs17376456 0.757 rs1031424 chr5:93139706 G/C cg09848695 chr5:92956644 FAM172A;MIR2277 0.61 5.64 0.3 3.59e-8 Diabetic retinopathy; CRC cis rs57994353 0.632 rs68142670 chr9:139324573 T/C cg14119001 chr9:139324193 INPP5E -0.53 -7.52 -0.38 5.18e-13 Eosinophil counts;Cutaneous squamous cell carcinoma; CRC cis rs2243480 0.901 rs2456483 chr7:65461575 T/C cg12463550 chr7:65579703 CRCP 0.65 6.2 0.32 1.67e-9 Diabetic kidney disease; CRC cis rs8062405 0.789 rs2106480 chr16:28537971 T/C cg16576597 chr16:28551801 NUPR1 0.44 6.75 0.35 6.53e-11 Cognitive ability (multi-trait analysis);Cognitive ability; CRC cis rs1035144 0.546 rs2215981 chr14:81444967 G/A cg06600135 chr14:81408086 NA -0.53 -7.86 -0.4 5.6e-14 Male sexual orientation; CRC cis rs2227564 0.620 rs11000765 chr10:75512452 G/C cg16540259 chr10:75572220 NDST2 0.49 7.4 0.38 1.13e-12 Crohn's disease;Inflammatory bowel disease; CRC cis rs7412746 0.553 rs59337856 chr1:150746406 G/T cg17724175 chr1:150552817 MCL1 0.48 7.08 0.36 8.66e-12 Melanoma; CRC cis rs2645694 0.626 rs2703143 chr4:77830441 A/G cg03477792 chr4:77819574 ANKRD56 0.46 6.62 0.34 1.48e-10 Emphysema distribution in smoking; CRC cis rs6662572 0.686 rs59091734 chr1:46285809 A/G cg03123370 chr1:45965343 CCDC163P;MMACHC 0.48 6.08 0.32 3.33e-9 Blood protein levels; CRC cis rs4713118 0.629 rs203890 chr6:28022248 T/C cg02683197 chr6:28174875 NA 0.76 9.96 0.48 1.33e-20 Parkinson's disease; CRC trans rs56283067 0.887 rs7349931 chr6:44783674 C/T cg12017007 chr17:27277572 PHF12 0.54 6.15 0.32 2.22e-9 Total body bone mineral density; CRC cis rs11758351 0.660 rs11759904 chr6:26231443 T/C cg08260959 chr6:26240920 HIST1H4F -0.35 -5.73 -0.3 2.24e-8 Gout;Renal underexcretion gout; CRC cis rs9811920 0.609 rs7636447 chr3:99612677 G/C cg07805332 chr3:99536008 MIR548G;C3orf26 -0.51 -7.66 -0.39 2.16e-13 Axial length; CRC cis rs2070488 0.560 rs1381798 chr3:38437471 C/T cg01465620 chr3:38496096 LOC100128640;ACVR2B -0.54 -7.64 -0.39 2.41e-13 Electrocardiographic conduction measures; CRC cis rs9326248 0.817 rs6589598 chr11:117002403 A/G cg15534755 chr11:117069859 TAGLN 0.35 5.95 0.31 6.96e-9 Blood protein levels; CRC cis rs208520 1.000 rs9453663 chr6:66976077 A/G cg07460842 chr6:66804631 NA 0.88 10.88 0.51 9.53e-24 Exhaled nitric oxide output; CRC cis rs921968 0.541 rs687747 chr2:219399627 T/C cg02176678 chr2:219576539 TTLL4 0.54 8.69 0.43 1.78e-16 Mean corpuscular hemoglobin concentration; CRC cis rs11098499 0.955 rs1511019 chr4:120166007 T/G cg09307838 chr4:120376055 NA 0.64 9.8 0.48 4.65e-20 Corneal astigmatism; CRC cis rs10791323 0.581 rs2723608 chr11:133710149 A/G cg15485101 chr11:133734466 NA 0.45 7.93 0.4 3.52e-14 Childhood ear infection; CRC cis rs9463078 0.683 rs911524 chr6:44747204 G/A cg25276700 chr6:44698697 NA 0.25 5.95 0.31 6.9e-9 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; CRC cis rs7412746 0.658 rs4970986 chr1:150907955 A/G cg17724175 chr1:150552817 MCL1 0.44 6.69 0.35 9.45e-11 Melanoma; CRC cis rs4713118 0.621 rs4713132 chr6:28034035 A/G cg12273811 chr6:28175739 NA 0.63 8.16 0.41 7.43e-15 Parkinson's disease; CRC cis rs1046896 0.739 rs2379358 chr17:80741612 G/A cg19046167 chr17:80928561 B3GNTL1 0.42 5.87 0.31 1.04e-8 Glycated hemoglobin levels; CRC cis rs4862750 0.914 rs10027250 chr4:187873460 T/C cg03452623 chr4:187889614 NA -0.88 -19.12 -0.73 2.47e-55 Lobe attachment (rater-scored or self-reported); CRC cis rs2645694 0.626 rs2703151 chr4:77834095 A/G cg03477792 chr4:77819574 ANKRD56 0.42 6.09 0.32 3.23e-9 Emphysema distribution in smoking; CRC cis rs3741151 0.773 rs73542967 chr11:73123512 C/T cg17517138 chr11:73019481 ARHGEF17 0.92 7.7 0.39 1.63e-13 GIP levels in response to oral glucose tolerance test (120 minutes); CRC cis rs8060686 0.920 rs2271293 chr16:67902070 A/G cg26727032 chr16:67993705 SLC12A4 0.55 6.41 0.33 5.01e-10 HDL cholesterol;Metabolic syndrome; CRC cis rs28386778 0.897 rs2584627 chr17:61901439 T/C cg25654072 chr17:61904446 PSMC5;FTSJ3 0.74 11.51 0.54 5.33e-26 Prudent dietary pattern; CRC cis rs17601876 0.814 rs3889391 chr15:51558422 G/A cg19946085 chr15:51559439 CYP19A1 -0.31 -6.16 -0.32 2.17e-9 Estrone/androstenedione ratio in resected early stage-receptor positive breast cancer; CRC trans rs2228479 0.850 rs1800339 chr16:89839637 C/A cg24644049 chr4:85504048 CDS1 0.9 7.57 0.39 3.72e-13 Skin colour saturation; CRC cis rs7586879 0.639 rs6749170 chr2:25110962 A/G cg22495460 chr2:25135724 ADCY3 -0.86 -16.45 -0.67 8.68e-45 Body mass index; CRC cis rs12692738 0.526 rs392050 chr2:165630793 G/A cg03182029 chr2:165697222 COBLL1 0.5 5.86 0.31 1.11e-8 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);Waist-to-hip ratio adjusted for BMI in non-smokers;Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction);Waist-to-hip ratio adjusted for body mass index; CRC cis rs8031584 0.918 rs61997139 chr15:31273602 C/G cg08109568 chr15:31115862 NA -0.52 -8.77 -0.44 9.97e-17 Huntington's disease progression; CRC trans rs1814175 0.717 rs11040450 chr11:49650638 G/A cg03929089 chr4:120376271 NA -0.93 -17.05 -0.68 3.89e-47 Height; CRC trans rs28551159 1 rs28551159 chr6:26376368 A/G cg06606381 chr12:133084897 FBRSL1 -0.75 -5.96 -0.31 6.36e-9 Urinary tract infection frequency; CRC cis rs10927875 0.578 rs10927859 chr1:16141862 C/T cg21385522 chr1:16154831 NA -1.06 -17.76 -0.7 5.67e-50 Dilated cardiomyopathy; CRC cis rs17376456 0.825 rs55724660 chr5:93276636 A/G cg09848695 chr5:92956644 FAM172A;MIR2277 0.67 5.78 0.3 1.76e-8 Diabetic retinopathy; CRC cis rs9649213 0.593 rs6465675 chr7:97982103 C/T cg00277769 chr7:97922759 BAIAP2L1 0.6 10.27 0.49 1.17e-21 Prostate cancer (SNP x SNP interaction); CRC cis rs9926296 0.605 rs7205053 chr16:89856763 G/C cg03388025 chr16:89894329 SPIRE2 0.41 8.08 0.41 1.28e-14 Vitiligo; CRC cis rs896854 0.738 rs1713669 chr8:95958637 C/G cg13393036 chr8:95962371 TP53INP1 -0.45 -6.86 -0.35 3.45e-11 Type 2 diabetes; CRC cis rs2730245 0.527 rs1188974 chr7:158665748 C/T cg24397884 chr7:158709396 WDR60 0.9 11.08 0.52 1.8e-24 Height; CRC cis rs6831352 0.918 rs2851249 chr4:100044822 T/C cg12011299 chr4:100065546 ADH4 0.5 9.55 0.47 3.18e-19 Alcohol dependence; CRC cis rs6495122 0.699 rs1378940 chr15:75083494 C/A cg14664628 chr15:75095509 CSK -0.69 -11.3 -0.53 3.19e-25 Caffeine consumption;Diastolic blood pressure;Coffee consumption; CRC cis rs96067 0.805 rs7522400 chr1:36613380 A/G cg25304816 chr1:36627734 MAP7D1 0.41 5.61 0.3 4.21e-8 Corneal structure; CRC cis rs10450586 0.932 rs10835154 chr11:27315356 G/A cg10370305 chr11:27303972 NA 0.35 5.69 0.3 2.76e-8 Total body bone mineral density; CRC trans rs10982213 0.830 rs2274163 chr9:117188714 C/T cg15985400 chr11:76091674 PRKRIR 0.43 6.71 0.35 8.56e-11 Interleukin-6 levels; CRC cis rs9393692 0.557 rs6918325 chr6:26327965 T/G cg13736514 chr6:26305472 NA -0.44 -7.13 -0.37 6.25e-12 Educational attainment; CRC cis rs2404602 0.735 rs11637490 chr15:76759565 A/G cg23625390 chr15:77176239 SCAPER -0.87 -13.87 -0.61 8.96e-35 Blood metabolite levels; CRC cis rs72772090 0.539 rs72773922 chr5:96116660 A/G cg17330273 chr5:96107758 CAST;ERAP1 -0.64 -5.86 -0.31 1.12e-8 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs7552404 1.000 rs4559448 chr1:76203456 A/G cg10523679 chr1:76189770 ACADM 0.83 11.32 0.53 2.68e-25 Blood metabolite levels;Acylcarnitine levels; CRC trans rs7618501 1.000 rs1491986 chr3:49739086 C/T cg21659725 chr3:3221576 CRBN -0.91 -17.91 -0.7 1.53e-50 Intelligence (multi-trait analysis); CRC trans rs12706411 0.717 rs17144531 chr7:122174453 A/C cg04149356 chr5:158139306 EBF1 0.63 6.02 0.31 4.62e-9 Alzheimer disease and age of onset; CRC cis rs12928939 0.517 rs8049508 chr16:71978313 C/T cg03805757 chr16:71968109 PKD1L3 -0.53 -7.24 -0.37 3.13e-12 Post bronchodilator FEV1; CRC cis rs10782582 0.586 rs1856791 chr1:76308942 C/T cg03433033 chr1:76189801 ACADM -0.4 -5.72 -0.3 2.41e-8 Daytime sleep phenotypes; CRC cis rs2730245 0.527 rs842707 chr7:158656012 C/T cg24397884 chr7:158709396 WDR60 0.93 11.28 0.53 3.74e-25 Height; CRC cis rs4964805 0.594 rs11111759 chr12:104163183 T/C cg02344784 chr12:104178138 NT5DC3 0.46 7.15 0.37 5.78e-12 Attention deficit hyperactivity disorder; CRC cis rs79387448 0.638 rs74731686 chr2:103043981 G/A cg09003973 chr2:102972529 NA 0.75 8.11 0.41 1.01e-14 Gut microbiota (bacterial taxa); CRC cis rs6964587 0.626 rs10266424 chr7:91503228 C/T cg17063962 chr7:91808500 NA -0.6 -9.4 -0.46 9.39e-19 Breast cancer; CRC cis rs921968 0.565 rs12694439 chr2:219590871 A/G cg02176678 chr2:219576539 TTLL4 -0.39 -6.24 -0.33 1.33e-9 Mean corpuscular hemoglobin concentration; CRC cis rs910316 0.737 rs398896 chr14:75482827 C/A cg11812906 chr14:75593930 NEK9 -0.57 -8.6 -0.43 3.23e-16 Height; CRC cis rs10504073 0.525 rs10081464 chr8:50058707 A/G cg00325661 chr8:49890786 NA 0.35 5.95 0.31 6.89e-9 Blood metabolite ratios; CRC cis rs6938 0.534 rs4886636 chr15:75196176 G/A cg09165964 chr15:75287851 SCAMP5 0.57 9.14 0.45 6.48e-18 Breast cancer; CRC cis rs7552404 0.590 rs1565717 chr1:76320441 T/C cg22875332 chr1:76189707 ACADM -0.56 -7.44 -0.38 8.87e-13 Blood metabolite levels;Acylcarnitine levels; CRC cis rs6963495 0.818 rs6961233 chr7:105150469 C/T cg02135003 chr7:105160482 PUS7 -0.89 -12.26 -0.56 9.87e-29 Bipolar disorder (body mass index interaction); CRC cis rs10876993 0.928 rs1689596 chr12:58053029 T/C cg15848620 chr12:58087721 OS9 -0.66 -9.22 -0.45 3.74e-18 Celiac disease or Rheumatoid arthritis; CRC cis rs6502050 0.835 rs56095560 chr17:80151304 C/T cg02741985 chr17:80059408 CCDC57 0.44 7.18 0.37 4.6e-12 Life satisfaction; CRC trans rs2303319 0.504 rs12473088 chr2:162485073 A/G cg18122310 chr12:50236657 BCDIN3D -0.75 -6.09 -0.32 3.1e-9 Cognitive function; CRC cis rs7264396 0.563 rs2425111 chr20:34319765 A/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.49 -6.55 -0.34 2.15e-10 Total cholesterol levels; CRC trans rs3001167 0.881 rs12566391 chr1:194554844 C/A cg22004422 chr13:113740730 MCF2L -0.58 -6.43 -0.33 4.51e-10 Obesity-related traits; CRC cis rs929354 0.742 rs3808317 chr7:156944460 A/G cg05182265 chr7:156933206 UBE3C -0.76 -14.38 -0.62 1.04e-36 Body mass index; CRC cis rs765787 0.530 rs3759892 chr15:45542709 A/G cg24006582 chr15:45444508 DUOX1 0.56 8.17 0.41 6.86e-15 Uric acid levels; CRC cis rs877282 0.891 rs11599917 chr10:762288 G/A cg06581033 chr10:766294 NA -0.51 -5.79 -0.3 1.62e-8 Uric acid levels; CRC cis rs6840360 0.638 rs2406974 chr4:152601841 G/A cg09659197 chr4:152720779 NA 0.44 8.78 0.44 9.11e-17 Intelligence (multi-trait analysis); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg14774160 chr17:4901081 INCA1;KIF1C 0.39 6.08 0.32 3.36e-9 Liver disease severity in Alagille syndrome; CRC cis rs6088813 0.925 rs4353719 chr20:33977349 G/A cg14752227 chr20:34000481 UQCC -0.37 -5.72 -0.3 2.33e-8 Height; CRC cis rs9612 1.000 rs1058 chr19:44268325 C/G cg08581076 chr19:44259116 C19orf61 0.48 6.18 0.32 1.86e-9 Exhaled nitric oxide output; CRC cis rs11608355 0.515 rs2287191 chr12:109931741 C/T cg05360138 chr12:110035743 NA 0.77 8.64 0.43 2.48e-16 Neuroticism; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg07926482 chr16:84651521 COTL1 -0.43 -6.56 -0.34 2.04e-10 Myopia (pathological); CRC cis rs1005277 0.579 rs2474571 chr10:38384639 T/G cg25517755 chr10:38738941 LOC399744 -0.44 -6.4 -0.33 5.45e-10 Extrinsic epigenetic age acceleration; CRC cis rs9925964 0.967 rs4889620 chr16:31131174 G/A cg03418659 chr16:31128414 MYST1 0.53 7.74 0.39 1.22e-13 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs7746199 0.668 rs34864796 chr6:27459923 G/A cg19041857 chr6:27730383 NA -0.77 -6.87 -0.35 3.3e-11 Gait speed in old age;Autism spectrum disorder or schizophrenia; CRC cis rs727563 0.638 rs4820443 chr22:42193913 A/G cg03806693 chr22:41940476 POLR3H -1.03 -12.86 -0.58 6e-31 Crohn's disease;Inflammatory bowel disease; CRC cis rs67478160 0.595 rs67768834 chr14:104221085 C/G cg01849466 chr14:104193079 ZFYVE21 -0.49 -8.76 -0.43 1.06e-16 Schizophrenia; CRC cis rs34172651 0.517 rs1465423 chr16:24772680 C/G cg06028605 chr16:24865363 SLC5A11 -0.59 -9.93 -0.48 1.65e-20 Intelligence (multi-trait analysis); CRC cis rs875971 0.862 rs4718319 chr7:65652784 C/A cg18252515 chr7:66147081 NA 0.39 5.6 0.3 4.46e-8 Aortic root size; CRC cis rs2949837 0.581 rs924140 chr7:45963114 C/T cg10677697 chr7:45961126 IGFBP3 0.35 6.26 0.33 1.18e-9 Sitting height ratio; CRC cis rs4423214 1.000 rs2282621 chr11:71183474 C/T cg05163923 chr11:71159392 DHCR7 0.66 9.3 0.46 2.04e-18 Vitamin D levels; CRC cis rs425277 0.628 rs262668 chr1:2082602 A/G cg12639453 chr1:2035780 PRKCZ 0.31 5.74 0.3 2.2e-8 Height; CRC trans rs2303319 0.504 rs62189053 chr2:162624324 G/A cg18122310 chr12:50236657 BCDIN3D -0.73 -6.35 -0.33 7.23e-10 Cognitive function; CRC cis rs12701220 0.901 rs12701708 chr7:1090333 C/T cg00990874 chr7:1149470 C7orf50 -0.51 -6.25 -0.33 1.26e-9 Bronchopulmonary dysplasia; CRC cis rs4819052 0.851 rs2236445 chr21:46678453 T/C cg11663144 chr21:46675770 NA -0.77 -12.73 -0.57 1.84e-30 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs6121246 0.559 rs6121038 chr20:30254773 T/G cg18721089 chr20:30220636 NA -0.33 -6.08 -0.32 3.37e-9 Mean corpuscular hemoglobin; CRC cis rs782590 0.967 rs4672054 chr2:55773093 C/A cg18811423 chr2:55921094 PNPT1 0.83 15.3 0.64 2.85e-40 Metabolic syndrome; CRC trans rs11098499 0.739 rs7441137 chr4:120133221 G/T cg25214090 chr10:38739885 LOC399744 -0.42 -6.74 -0.35 7.27e-11 Corneal astigmatism; CRC cis rs2276314 1.000 rs8086395 chr18:33564592 C/G cg19628046 chr18:33552617 C18orf21 0.5 6.86 0.35 3.48e-11 Endometriosis;Drug-induced torsades de pointes; CRC cis rs9916302 0.904 rs602688 chr17:37439496 C/T cg15445000 chr17:37608096 MED1 0.39 8.45 0.42 9.54e-16 Glomerular filtration rate (creatinine); CRC cis rs12230513 0.732 rs67290413 chr12:55869876 T/C cg19537932 chr12:55886519 OR6C68 -0.72 -9.15 -0.45 6.05e-18 Contrast sensitivity; CRC cis rs801193 0.527 rs2707837 chr7:66181073 G/C cg18876405 chr7:65276391 NA 0.51 8.24 0.41 4.19e-15 Aortic root size; CRC cis rs6499255 0.951 rs57565297 chr16:69723122 G/T cg15192750 chr16:69999425 NA 0.58 7.66 0.39 2.13e-13 IgE levels; CRC trans rs1814175 0.645 rs1851849 chr11:50012164 G/A cg15704280 chr7:45808275 SEPT13 -0.92 -16.64 -0.68 1.6e-45 Height; CRC cis rs7811142 0.779 rs77370288 chr7:99947897 A/T cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.16 16.51 0.67 5.05e-45 Platelet count; CRC cis rs473651 0.935 rs35080527 chr2:239351387 T/C cg08773314 chr2:239334832 ASB1 0.38 8.57 0.43 4.12e-16 Multiple system atrophy; CRC cis rs28386778 0.897 rs4638645 chr17:61828349 T/C cg11494091 chr17:61959527 GH2 0.63 10.73 0.51 3.01e-23 Prudent dietary pattern; CRC cis rs9486719 1.000 rs12205728 chr6:96891838 T/C cg06623918 chr6:96969491 KIAA0776 -0.81 -9.51 -0.46 4.17e-19 Migraine;Coronary artery disease; CRC cis rs3806843 0.576 rs155361 chr5:140307284 G/A cg19875535 chr5:140030758 IK 0.4 6.21 0.32 1.57e-9 Depressive symptoms (multi-trait analysis); CRC trans rs11098499 0.754 rs17049949 chr4:120255290 A/G cg25214090 chr10:38739885 LOC399744 0.54 8.52 0.43 5.9e-16 Corneal astigmatism; CRC cis rs2228479 0.867 rs2270459 chr16:89979851 A/C cg06558623 chr16:89946397 TCF25 -0.79 -9.03 -0.45 1.43e-17 Skin colour saturation; CRC cis rs10170846 0.893 rs12614976 chr2:223542896 A/T cg25565276 chr2:223520875 FARSB 0.54 7.49 0.38 6.25e-13 Schizophrenia (inflammation and infection response interaction); CRC cis rs11190604 1.000 rs4919468 chr10:102288343 G/C cg16342193 chr10:102329863 NA -0.4 -6.45 -0.34 3.9e-10 Palmitoleic acid (16:1n-7) levels; CRC cis rs847649 1.000 rs1100046 chr7:102549295 T/A cg18108683 chr7:102477205 FBXL13 -0.57 -9.27 -0.45 2.6e-18 Morning vs. evening chronotype; CRC cis rs9611565 0.765 rs132914 chr22:41805749 T/C cg03806693 chr22:41940476 POLR3H 0.99 12.4 0.56 2.99e-29 Vitiligo; CRC cis rs4664293 0.801 rs7589771 chr2:160584132 C/T cg08347373 chr2:160653686 CD302 -0.35 -5.61 -0.3 4.36e-8 Monocyte percentage of white cells; CRC cis rs6714710 0.535 rs13033383 chr2:98339513 C/T cg26665480 chr2:98280029 ACTR1B 0.53 7.16 0.37 5.4e-12 Posterior cortical atrophy and Alzheimer's disease; CRC cis rs11971779 0.680 rs4732373 chr7:139086535 T/G cg07862535 chr7:139043722 LUC7L2 0.57 7.35 0.38 1.61e-12 Diisocyanate-induced asthma; CRC cis rs17155006 0.664 rs448833 chr7:107739181 A/G cg05962710 chr7:107745446 LAMB4 -0.43 -7.53 -0.38 4.79e-13 Pneumococcal bacteremia; CRC cis rs2274471 0.540 rs10815162 chr9:5122291 G/C cg03390472 chr9:5043263 JAK2 -0.51 -5.88 -0.31 9.97e-9 Crohn's disease; CRC cis rs3789045 0.560 rs2271424 chr1:204403311 A/G cg17419461 chr1:204415978 PIK3C2B -0.81 -10.92 -0.52 6.99e-24 Educational attainment (college completion); CRC cis rs427941 0.667 rs201436 chr7:101733576 T/C cg06246474 chr7:101738831 CUX1 0.45 7.1 0.36 7.51e-12 Plasma omega-3 polyunsaturated fatty acid level (eicosapentaenoic acid); CRC trans rs116095464 0.681 rs9687745 chr5:229309 C/T cg00938859 chr5:1591904 SDHAP3 0.72 7.96 0.4 2.76e-14 Breast cancer; CRC cis rs6764363 0.527 rs13062390 chr3:280054 C/T cg02057681 chr3:285234 CHL1 0.42 7.13 0.37 6.58e-12 Sudden cardiac arrest; CRC cis rs262150 0.544 rs2428780 chr7:158812471 T/A cg19418458 chr7:158789849 NA -0.49 -8.52 -0.43 5.93e-16 Facial morphology (factor 20); CRC cis rs6088580 0.634 rs1205334 chr20:32930369 T/C cg24642439 chr20:33292090 TP53INP2 -0.41 -6.94 -0.36 2.08e-11 Glomerular filtration rate (creatinine); CRC cis rs10791323 0.569 rs2298738 chr11:133715153 G/C cg06766960 chr11:133703094 NA -0.34 -5.65 -0.3 3.39e-8 Childhood ear infection; CRC cis rs7829975 0.626 rs907183 chr8:8729761 C/G cg11608241 chr8:8085544 FLJ10661 -0.39 -5.68 -0.3 2.93e-8 Mood instability; CRC cis rs2882667 0.861 rs10037106 chr5:138365490 G/T cg09476006 chr5:138032270 NA 0.44 7.31 0.37 2.05e-12 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs17095355 1.000 rs12244557 chr10:111746142 T/C cg00817464 chr10:111662876 XPNPEP1 -0.63 -8.52 -0.42 6.01e-16 Biliary atresia; CRC cis rs1448094 0.511 rs61930579 chr12:86157044 G/A cg25456477 chr12:86230367 RASSF9 0.39 6.45 0.34 3.89e-10 Major depressive disorder; CRC cis rs7772486 0.790 rs1832362 chr6:146179955 C/T cg13319975 chr6:146136371 FBXO30 -0.41 -6.19 -0.32 1.82e-9 Lobe attachment (rater-scored or self-reported); CRC trans rs2303319 0.504 rs62187609 chr2:162431500 C/T cg11875773 chr22:50468633 TTLL8 -0.7 -6.07 -0.32 3.62e-9 Cognitive function; CRC cis rs9443645 0.901 rs7742034 chr6:79737106 A/G cg05283184 chr6:79620031 NA -0.62 -9.82 -0.48 3.99e-20 Intelligence (multi-trait analysis); CRC cis rs9914988 0.943 rs3181215 chr17:27077331 C/T cg16670446 chr17:27188758 MIR451;MIR144 -0.57 -9.54 -0.47 3.26e-19 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC trans rs916888 0.610 rs199438 chr17:44791643 G/A cg22433210 chr17:43662623 NA 0.64 7.74 0.39 1.2e-13 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC trans rs1005277 0.579 rs1740749 chr10:38521646 A/G cg27523141 chr10:43048294 ZNF37B 0.47 6.9 0.36 2.69e-11 Extrinsic epigenetic age acceleration; CRC cis rs709400 0.659 rs7160366 chr14:103944137 C/T cg12935359 chr14:103987150 CKB -0.51 -7.97 -0.4 2.58e-14 Body mass index; CRC cis rs7552404 0.924 rs7550974 chr1:76204185 A/G cg03433033 chr1:76189801 ACADM 0.91 13.8 0.61 1.76e-34 Blood metabolite levels;Acylcarnitine levels; CRC cis rs988712 0.550 rs988748 chr11:27724745 C/G cg10635145 chr11:27742435 BDNF 0.4 6.02 0.32 4.64e-9 Obesity; CRC cis rs9469913 0.675 rs6907508 chr6:34592090 A/G cg17674042 chr6:34482479 PACSIN1 -0.74 -7.12 -0.37 6.88e-12 Body mass index (joint analysis main effects and physical activity interaction);Body mass index;Body mass index in physically active individuals; CRC cis rs7666738 0.830 rs13149346 chr4:99009933 C/T cg17366294 chr4:99064904 C4orf37 0.44 7.39 0.38 1.19e-12 Colonoscopy-negative controls vs population controls; CRC cis rs9902453 0.967 rs3813034 chr17:28524804 A/C cg26525008 chr17:28256777 EFCAB5;SSH2 0.6 9.23 0.45 3.43e-18 Coffee consumption (cups per day); CRC cis rs514406 0.644 rs4926928 chr1:53210163 G/T cg27535305 chr1:53392650 SCP2 -0.35 -6.32 -0.33 8.43e-10 Monocyte count; CRC cis rs11105298 0.891 rs11105299 chr12:89877943 A/G cg08166232 chr12:89918718 WDR51B;GALNT4 -0.61 -7.73 -0.39 1.28e-13 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; CRC cis rs8078723 1.000 rs709592 chr17:38175553 C/T cg17344932 chr17:38183730 MED24;SNORD124 -0.46 -7.19 -0.37 4.47e-12 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); CRC cis rs11997175 0.587 rs72612118 chr8:33695225 T/C cg04338863 chr8:33670619 NA 0.42 6.72 0.35 7.87e-11 Body mass index; CRC cis rs13108904 0.557 rs1680030 chr4:1245500 A/T cg16405210 chr4:1374714 KIAA1530 0.74 10.51 0.5 1.85e-22 Obesity-related traits; CRC cis rs11190604 0.943 rs11190574 chr10:102234331 T/C cg07080220 chr10:102295463 HIF1AN 0.48 5.79 0.3 1.63e-8 Palmitoleic acid (16:1n-7) levels; CRC cis rs11098499 0.697 rs4373140 chr4:120307698 A/G cg09307838 chr4:120376055 NA 0.71 10.93 0.52 6.41e-24 Corneal astigmatism; CRC cis rs55692411 0.537 rs35012435 chr3:50031840 C/T cg24110177 chr3:50126178 RBM5 -0.49 -5.72 -0.3 2.34e-8 Intelligence (multi-trait analysis); CRC cis rs881375 0.654 rs10760126 chr9:123662618 T/C cg09419670 chr9:123605666 PSMD5;LOC253039 0.52 8.32 0.42 2.35e-15 Rheumatoid arthritis; CRC cis rs8050260 0.500 rs4783650 chr16:68558528 T/C cg02972257 chr16:68554789 NA 0.63 7.34 0.37 1.74e-12 Plateletcrit; CRC cis rs1223397 0.938 rs3817738 chr6:13279388 G/T cg21538684 chr6:13274180 PHACTR1 0.5 5.75 0.3 2.04e-8 Blood pressure; CRC cis rs3771570 0.901 rs62190407 chr2:242405772 G/A cg21155796 chr2:242212141 HDLBP 0.56 6.52 0.34 2.64e-10 Prostate cancer; CRC cis rs6754311 0.731 rs748841 chr2:136558157 C/T cg15123519 chr2:136567270 LCT 0.32 6.32 0.33 8.6e-10 Mosquito bite size; CRC cis rs651907 0.535 rs12631513 chr3:101517476 A/C cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.59 7.86 0.4 5.42e-14 Colorectal cancer; CRC cis rs10426930 0.547 rs2054519 chr19:5059360 T/C cg18473234 chr19:5097819 KDM4B -0.53 -6.61 -0.34 1.54e-10 Monocyte percentage of white cells; CRC cis rs9916302 0.800 rs11869259 chr17:37518141 C/A cg03013999 chr17:37608204 MED1 -0.47 -7.25 -0.37 2.91e-12 Glomerular filtration rate (creatinine); CRC cis rs896854 0.654 rs16893776 chr8:95973604 C/T cg13393036 chr8:95962371 TP53INP1 -0.54 -9.27 -0.46 2.53e-18 Type 2 diabetes; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg05434655 chr2:178078121 HNRNPA3 0.44 6.2 0.32 1.67e-9 Intelligence (multi-trait analysis); CRC cis rs10504229 1.000 rs67594249 chr8:58180521 T/A cg02290350 chr8:58132656 NA -0.42 -5.96 -0.31 6.62e-9 Developmental language disorder (linguistic errors); CRC cis rs4588572 0.561 rs7727592 chr5:77804547 G/A cg11547950 chr5:77652471 NA -0.44 -6.36 -0.33 6.82e-10 Triglycerides; CRC cis rs72615157 0.612 rs7786505 chr7:99817585 G/T cg07160278 chr7:100027354 MEPCE;ZCWPW1 0.63 7.5 0.38 6.01e-13 Lung function (FEV1/FVC); CRC cis rs7618501 0.633 rs4688689 chr3:50035542 C/T cg24308560 chr3:49941425 MST1R -0.52 -8.22 -0.41 4.61e-15 Intelligence (multi-trait analysis); CRC trans rs7615952 0.599 rs6803160 chr3:125709554 G/T cg07211511 chr3:129823064 LOC729375 -0.77 -10.73 -0.51 3.08e-23 Blood pressure (smoking interaction); CRC cis rs5750830 0.649 rs4821893 chr22:39797779 G/A cg24399712 chr22:39784796 NA -0.49 -9.47 -0.46 5.79e-19 Intelligence (multi-trait analysis); CRC cis rs10504073 0.647 rs4348510 chr8:50016027 C/A cg00325661 chr8:49890786 NA 0.43 7.69 0.39 1.67e-13 Blood metabolite ratios; CRC trans rs1903068 0.927 rs12331507 chr4:56011889 A/G cg27327334 chr3:48484191 CCDC72 -0.39 -6.73 -0.35 7.77e-11 Endometriosis; CRC cis rs6598955 0.724 rs12132137 chr1:26631243 C/T cg04990556 chr1:26633338 UBXN11 -0.78 -13.06 -0.58 1.06e-31 Obesity-related traits; CRC cis rs1387259 0.570 rs12368659 chr12:48562299 C/A cg15465823 chr12:48382534 COL2A1 0.37 6.11 0.32 2.75e-9 Obstructive sleep apnea trait (apnea hypopnea index); CRC cis rs514406 0.861 rs4926932 chr1:53247495 C/T cg25767906 chr1:53392781 SCP2 0.45 7.22 0.37 3.55e-12 Monocyte count; CRC cis rs11585357 0.501 rs17458091 chr1:17595925 A/G cg08277548 chr1:17600880 PADI3 -0.59 -7.35 -0.38 1.54e-12 Hair shape; CRC cis rs12745968 0.589 rs7417452 chr1:93032053 A/G cg17283838 chr1:93427260 FAM69A -0.47 -6.3 -0.33 9.54e-10 Bipolar disorder and schizophrenia; CRC cis rs4481887 1.000 rs4306162 chr1:248468509 C/T cg00666640 chr1:248458726 OR2T12 0.52 9.16 0.45 5.86e-18 Common traits (Other); CRC cis rs9611519 0.964 rs20551 chr22:41548008 A/G cg06634786 chr22:41940651 POLR3H -0.51 -6.45 -0.33 4.02e-10 Neuroticism; CRC cis rs6500602 0.893 rs4786489 chr16:4485527 G/A cg08645402 chr16:4508243 NA 0.56 9.03 0.45 1.49e-17 Schizophrenia; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg20795550 chr18:12702739 PSMG2;CEP76 0.45 6.24 0.33 1.37e-9 Anxiety disorder; CRC cis rs9520326 1.000 rs9520326 chr13:107865442 T/C cg07094987 chr13:107865374 FAM155A -0.37 -5.85 -0.31 1.21e-8 Obsessive-compulsive symptoms; CRC cis rs1218582 0.710 rs9793588 chr1:154878878 C/G cg09359103 chr1:154839909 KCNN3 -0.7 -12.29 -0.56 8.25e-29 Prostate cancer; CRC cis rs72615157 0.613 rs56089143 chr7:99819844 G/A cg07160278 chr7:100027354 MEPCE;ZCWPW1 0.63 7.5 0.38 6.01e-13 Lung function (FEV1/FVC); CRC trans rs7267979 0.844 rs8184820 chr20:25250577 C/T cg17903999 chr18:56338584 MALT1 0.41 6.63 0.34 1.36e-10 Liver enzyme levels (alkaline phosphatase); CRC cis rs4862750 0.872 rs7672831 chr4:187898882 C/T cg11301795 chr4:187892539 NA -0.86 -20.17 -0.74 1.85e-59 Lobe attachment (rater-scored or self-reported); CRC cis rs7914558 1.000 rs1926030 chr10:104855656 T/C cg15744005 chr10:104629667 AS3MT -0.35 -7.48 -0.38 6.97e-13 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs10479542 0.896 rs4701130 chr5:178982416 C/T cg05457628 chr5:178986728 RUFY1 -0.41 -7.01 -0.36 1.36e-11 Lung cancer; CRC cis rs514406 0.825 rs9661082 chr1:53245472 A/T cg08859206 chr1:53392774 SCP2 0.44 6.74 0.35 7.19e-11 Monocyte count; CRC cis rs7937682 0.602 rs4936804 chr11:111743851 A/C cg09085632 chr11:111637200 PPP2R1B 0.95 15.63 0.65 1.46e-41 Primary sclerosing cholangitis; CRC cis rs7918232 0.556 rs788209 chr10:27434716 G/T cg14442939 chr10:27389572 ANKRD26 0.94 9.63 0.47 1.71e-19 Breast cancer; CRC cis rs7258465 1.000 rs10164323 chr19:18569492 C/T cg01065977 chr19:18549689 ISYNA1 -0.41 -6.45 -0.34 3.94e-10 Breast cancer; CRC cis rs2836974 0.899 rs114399588 chr21:40653958 G/A cg11890956 chr21:40555474 PSMG1 1.03 16.35 0.67 2.07e-44 Cognitive function; CRC cis rs2276314 1.000 rs62101367 chr18:33550884 C/T cg05985134 chr18:33552581 C18orf21 0.52 7.09 0.36 8.43e-12 Endometriosis;Drug-induced torsades de pointes; CRC cis rs270601 0.909 rs2569265 chr5:131704519 T/C cg22638593 chr5:131593259 PDLIM4 -0.39 -6.39 -0.33 5.57e-10 Acylcarnitine levels; CRC cis rs1801251 1.000 rs283471 chr2:233656627 G/A cg25237894 chr2:233734115 C2orf82 0.56 9.11 0.45 8.31e-18 Coronary artery disease; CRC cis rs939584 0.735 rs13035713 chr2:633659 T/C cg03610516 chr2:642275 NA 0.42 5.65 0.3 3.49e-8 Body mass index; CRC cis rs4713118 0.662 rs156744 chr6:27967274 G/A cg21251018 chr6:28226885 NKAPL 0.44 6.58 0.34 1.81e-10 Parkinson's disease; CRC cis rs1878931 0.597 rs37814 chr16:3455247 C/T cg02880119 chr16:3481970 NA 0.42 5.7 0.3 2.62e-8 Body mass index (adult); CRC cis rs3768617 0.510 rs10797839 chr1:183077797 A/G ch.1.3577855R chr1:183094577 LAMC1 0.87 15.51 0.65 4.16e-41 Fuchs's corneal dystrophy; CRC cis rs9372498 0.505 rs62424202 chr6:118851027 T/C cg07617317 chr6:118971624 C6orf204 0.46 5.71 0.3 2.52e-8 Diastolic blood pressure; CRC cis rs10512697 0.655 rs35928407 chr5:3503392 G/C cg19473799 chr5:3511975 NA -0.82 -6.32 -0.33 8.41e-10 Immune response to smallpox vaccine (IL-6); CRC cis rs9287719 0.967 rs7587231 chr2:10740093 C/T cg00105475 chr2:10696890 NA 0.45 7.3 0.37 2.19e-12 Prostate cancer; CRC cis rs9443645 0.869 rs9343827 chr6:79501036 A/G cg11833968 chr6:79620685 NA -0.35 -6.1 -0.32 2.98e-9 Intelligence (multi-trait analysis); CRC cis rs2839186 0.771 rs13049175 chr21:47641326 G/A cg26721908 chr21:47610096 LSS 0.41 6.28 0.33 1.04e-9 Testicular germ cell tumor; CRC cis rs11168351 0.864 rs10875743 chr12:48498413 C/T cg24011408 chr12:48396354 COL2A1 -0.43 -6.34 -0.33 7.49e-10 Bipolar disorder and schizophrenia; CRC cis rs4689388 0.926 rs10937717 chr4:6295087 T/A cg14416269 chr4:6271139 WFS1 0.38 6.19 0.32 1.74e-9 Type 2 diabetes and other traits;Type 2 diabetes; CRC cis rs28386778 0.805 rs9911714 chr17:61828952 G/A cg06601766 chr17:61851465 DDX42;CCDC47 0.44 6.05 0.32 4.05e-9 Prudent dietary pattern; CRC cis rs7618915 0.547 rs34537256 chr3:52657472 A/G cg18099408 chr3:52552593 STAB1 -0.44 -7.12 -0.37 6.88e-12 Bipolar disorder; CRC cis rs1150668 0.699 rs1736895 chr6:28219826 G/A cg12273811 chr6:28175739 NA 0.37 5.67 0.3 3.17e-8 Pubertal anthropometrics; CRC cis rs11098499 1.000 rs7659194 chr4:120207147 T/G cg09307838 chr4:120376055 NA 0.65 9.99 0.48 1.08e-20 Corneal astigmatism; CRC cis rs1552244 0.935 rs7649243 chr3:10089470 T/A cg16606324 chr3:10149918 C3orf24 0.72 9.82 0.48 3.92e-20 Alzheimer's disease; CRC cis rs5750830 0.649 rs6001588 chr22:39819049 G/C cg05872129 chr22:39784769 NA -0.57 -10.08 -0.49 5.26e-21 Intelligence (multi-trait analysis); CRC cis rs9291683 0.527 rs3822247 chr4:10094671 G/A cg00071950 chr4:10020882 SLC2A9 -0.51 -8.48 -0.42 7.71e-16 Bone mineral density; CRC cis rs1552244 0.882 rs13074282 chr3:10024699 T/G cg13047869 chr3:10149882 C3orf24 0.51 6.91 0.36 2.54e-11 Alzheimer's disease; CRC cis rs1448094 0.845 rs10863123 chr12:86346254 G/A cg02569458 chr12:86230093 RASSF9 0.4 6.83 0.35 4.18e-11 Major depressive disorder; CRC cis rs11190604 0.767 rs4559620 chr10:102199935 C/T cg16342193 chr10:102329863 NA -0.37 -6.03 -0.32 4.36e-9 Palmitoleic acid (16:1n-7) levels; CRC cis rs6951245 0.935 rs118132455 chr7:1068232 C/A cg26224354 chr7:1096374 C7orf50;GPR146 -0.88 -11.08 -0.52 1.89e-24 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs35883536 0.967 rs1984134 chr1:101109307 A/G cg14515779 chr1:101123966 NA -0.43 -8.3 -0.42 2.82e-15 Monocyte count; CRC cis rs4664293 0.867 rs7562060 chr2:160587129 T/G cg08347373 chr2:160653686 CD302 -0.47 -7.43 -0.38 9.32e-13 Monocyte percentage of white cells; CRC cis rs1799949 1.000 rs8176269 chr17:41213626 G/T cg05368731 chr17:41323189 NBR1 0.65 9.48 0.46 5.19e-19 Menopause (age at onset); CRC cis rs2976388 0.524 rs7012804 chr8:143844650 A/G cg24046110 chr8:143859143 LYNX1 0.61 10.8 0.51 1.84e-23 Urinary tract infection frequency; CRC cis rs1403694 0.515 rs1648700 chr3:186449916 C/T cg04611788 chr3:186434169 KNG1 0.58 8.34 0.42 2.08e-15 Blood protein levels; CRC cis rs3018066 0.589 rs56053435 chr4:107028186 T/A cg01869342 chr4:106983673 TBCK 0.43 5.74 0.3 2.14e-8 Cancer; CRC cis rs7095944 0.644 rs4962694 chr10:126436717 G/T cg08799069 chr10:126477246 METTL10 -0.44 -6.75 -0.35 6.84e-11 Asthma; CRC cis rs231513 0.954 rs231501 chr17:41972303 C/T cg26893861 chr17:41843967 DUSP3 -0.62 -6.36 -0.33 6.9e-10 Cognitive function; CRC cis rs12681287 0.577 rs13257414 chr8:87494138 C/T cg27223183 chr8:87520930 FAM82B -0.53 -7.62 -0.39 2.64e-13 Caudate activity during reward; CRC trans rs11098499 0.909 rs7681978 chr4:120383775 T/C cg25214090 chr10:38739885 LOC399744 0.66 10.55 0.5 1.36e-22 Corneal astigmatism; CRC cis rs7833790 0.660 rs1451995 chr8:82746123 G/C cg17211192 chr8:82754475 SNX16 0.47 6.61 0.34 1.59e-10 Diastolic blood pressure; CRC cis rs826838 1.000 rs826892 chr12:39100790 T/C cg26384229 chr12:38710491 ALG10B -0.61 -9.61 -0.47 1.92e-19 Heart rate; CRC trans rs9747201 1.000 rs9303020 chr17:80163247 C/T cg07393940 chr7:158741817 NA 0.5 7.24 0.37 3.1e-12 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs4474465 0.920 rs7947852 chr11:78198030 T/C cg27205649 chr11:78285834 NARS2 -0.48 -6.08 -0.32 3.34e-9 Alzheimer's disease (survival time); CRC cis rs6694270 0.913 rs11261069 chr1:19117300 C/G cg19637330 chr1:19110922 NA -0.49 -6.8 -0.35 4.86e-11 Drug-induced liver injury (nitrofurantoin); CRC cis rs9322193 0.887 rs11155662 chr6:149913867 T/G cg04369109 chr6:150039330 LATS1 -0.43 -5.62 -0.3 4.04e-8 Lung cancer; CRC cis rs8062405 1.000 rs56358680 chr16:28843118 A/G cg16576597 chr16:28551801 NUPR1 0.48 6.89 0.35 2.93e-11 Cognitive ability (multi-trait analysis);Cognitive ability; CRC cis rs17152411 1.000 rs7092008 chr10:126638226 G/A cg07906193 chr10:126599966 NA 0.63 6.92 0.36 2.34e-11 Height; CRC cis rs375066 0.592 rs349046 chr19:44300626 C/T cg12072164 chr19:44306565 LYPD5 -0.39 -6.19 -0.32 1.75e-9 Breast cancer; CRC cis rs7119 0.717 rs8032405 chr15:77825344 A/G cg10437265 chr15:77819839 NA 0.63 11.19 0.52 7.68e-25 Type 2 diabetes; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg01246254 chr10:124134882 PLEKHA1 -0.42 -5.98 -0.31 5.7e-9 Myopia (pathological); CRC trans rs2727020 0.796 rs7131672 chr11:49274421 A/C cg03929089 chr4:120376271 NA 0.59 7.71 0.39 1.48e-13 Coronary artery disease; CRC trans rs2228479 0.717 rs2074904 chr16:89811546 A/G cg21302420 chr1:112162376 RAP1A 0.72 6.01 0.31 5.05e-9 Skin colour saturation; CRC cis rs796364 1.000 rs11680723 chr2:200810957 C/G cg12253985 chr2:200820533 C2orf60;C2orf47 -0.62 -6.03 -0.32 4.37e-9 Schizophrenia; CRC cis rs8078723 0.933 rs4794822 chr17:38156712 C/T cg17344932 chr17:38183730 MED24;SNORD124 -0.44 -6.9 -0.36 2.64e-11 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); CRC cis rs780096 0.526 rs1260341 chr2:27663215 T/A cg21248554 chr2:27665150 KRTCAP3 -0.34 -7.95 -0.4 3.07e-14 Total body bone mineral density; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg03911494 chr16:71660463 MARVELD3 0.38 6.07 0.32 3.5e-9 Liver disease severity in Alagille syndrome; CRC cis rs9916302 0.904 rs7223331 chr17:37482930 A/G cg03013999 chr17:37608204 MED1 -0.47 -7.33 -0.37 1.78e-12 Glomerular filtration rate (creatinine); CRC cis rs67311347 0.713 rs73073505 chr3:40310693 C/T cg09455208 chr3:40491958 NA 0.41 8.02 0.4 1.92e-14 Renal cell carcinoma; CRC cis rs12936587 0.564 rs7208561 chr17:17615528 C/T cg09796270 chr17:17721594 SREBF1 0.4 6.52 0.34 2.6200000000000003e-10 Hip circumference;Coronary artery disease or large artery stroke;Coronary heart disease;Coronary artery disease; CRC cis rs4727027 0.769 rs2140957 chr7:148758885 A/G cg23583168 chr7:148888333 NA -0.89 -14.78 -0.63 2.93e-38 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC cis rs35110281 0.667 rs4819288 chr21:45120173 C/G cg21573476 chr21:45109991 RRP1B -0.39 -5.83 -0.31 1.35e-8 Mean corpuscular volume; CRC cis rs796364 0.664 rs3106089 chr2:200884615 A/C cg25936922 chr2:200820526 C2orf60;C2orf47 0.68 6.64 0.34 1.33e-10 Schizophrenia; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg07025478 chr12:66563505 TMBIM4 0.46 6.56 0.34 2.11e-10 Response to antipsychotic treatment; CRC cis rs6693567 0.586 rs9661040 chr1:150483236 A/C cg15654264 chr1:150340011 RPRD2 0.4 5.73 0.3 2.27e-8 Migraine; CRC cis rs72945132 0.562 rs7951959 chr11:70234272 A/G cg00319359 chr11:70116639 PPFIA1 0.54 5.62 0.3 3.97e-8 Coronary artery disease; CRC cis rs12477438 0.520 rs13004491 chr2:99738008 T/C cg26064155 chr2:99771622 LIPT1;TSGA10 0.89 16.26 0.67 4.63e-44 Chronic sinus infection; CRC cis rs225245 0.755 rs226432 chr17:34043825 G/A cg05299278 chr17:33885742 SLFN14 -0.5 -8.09 -0.41 1.13e-14 Reticulocyte count;Reticulocyte fraction of red cells;High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells; CRC cis rs887829 0.507 rs10929301 chr2:234663649 C/G cg02227331 chr2:234663937 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 0.35 5.6 0.3 4.41e-8 Metabolic traits;Bilirubin levels;Cholelithiasis-related traits in sickle cell anemia;Metabolite levels;Total bilirubin levels in HIV-1 infection;Serum metabolite levels;Blood metabolite levels; CRC cis rs6860806 0.507 rs273917 chr5:131659618 A/G cg22638593 chr5:131593259 PDLIM4 0.39 6.32 0.33 8.28e-10 Breast cancer; CRC cis rs733592 0.507 rs56129148 chr12:48485530 T/C cg24011408 chr12:48396354 COL2A1 -0.46 -6.78 -0.35 5.56e-11 Plateletcrit; CRC cis rs1448094 0.511 rs4278581 chr12:86151054 A/G cg06740227 chr12:86229804 RASSF9 -0.37 -5.64 -0.3 3.71e-8 Major depressive disorder; CRC cis rs1577917 0.958 rs2324839 chr6:86536942 T/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.49 -6.58 -0.34 1.82e-10 Response to antipsychotic treatment; CRC cis rs3857536 0.813 rs4710581 chr6:66939954 T/C cg07460842 chr6:66804631 NA -0.43 -5.81 -0.3 1.48e-8 Blood trace element (Cu levels); CRC cis rs3796619 1.000 rs4974601 chr4:1095410 G/A cg11579758 chr4:1086637 RNF212 0.4 6.42 0.33 4.7e-10 Recombination rate (males); CRC cis rs9910055 0.762 rs7213436 chr17:42252163 A/G cg19774624 chr17:42201019 HDAC5 0.68 9.96 0.48 1.33e-20 Total body bone mineral density; CRC cis rs9612 0.948 rs12609587 chr19:44268654 T/C cg08581076 chr19:44259116 C19orf61 0.48 6.18 0.32 1.86e-9 Exhaled nitric oxide output; CRC cis rs9325144 0.647 rs7487395 chr12:38865660 C/A cg26384229 chr12:38710491 ALG10B -0.51 -7.26 -0.37 2.76e-12 Morning vs. evening chronotype; CRC cis rs13191362 1.000 rs28360546 chr6:163210973 G/A cg21926612 chr6:163149169 PACRG;PARK2 0.94 11.93 0.55 1.7e-27 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC trans rs6550704 0.687 rs9865314 chr3:22634337 A/G cg00261534 chr10:3826854 KLF6 -0.43 -6.33 -0.33 7.95e-10 Daytime sleep phenotypes; CRC cis rs12325245 0.536 rs8058781 chr16:58653838 G/A cg01472538 chr16:58549086 SETD6 1.12 7.38 0.38 1.28e-12 Schizophrenia; CRC cis rs7737355 0.947 rs244736 chr5:130816178 T/C cg06307176 chr5:131281290 NA 0.42 6.36 0.33 6.61e-10 Life satisfaction; CRC cis rs3126085 0.935 rs74127901 chr1:152195579 G/A cg09127314 chr1:152161683 NA -0.49 -5.65 -0.3 3.45e-8 Atopic dermatitis; CRC cis rs7107174 1.000 rs1017908 chr11:77948095 A/G cg02023728 chr11:77925099 USP35 0.54 7.69 0.39 1.75e-13 Testicular germ cell tumor; CRC cis rs10504229 0.569 rs75466737 chr8:58055034 A/G cg22535103 chr8:58192502 C8orf71 -0.8 -8.75 -0.43 1.12e-16 Developmental language disorder (linguistic errors); CRC cis rs2153535 0.580 rs9393025 chr6:8490618 G/A cg07606381 chr6:8435919 SLC35B3 0.67 10.78 0.51 2.07e-23 Motion sickness; CRC cis rs13315871 1.000 rs13060489 chr3:58339287 G/A cg20936604 chr3:58311152 NA -0.79 -7.42 -0.38 1e-12 Cholesterol, total; CRC cis rs7635838 0.819 rs7637414 chr3:11522228 C/G cg00170343 chr3:11313890 ATG7 0.43 6.5 0.34 3.01e-10 HDL cholesterol; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg22947007 chr19:12886204 HOOK2 0.48 6.79 0.35 5.09e-11 Response to antipsychotic treatment; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg03039399 chr16:3930658 CREBBP 0.39 5.99 0.31 5.45e-9 Liver disease severity in Alagille syndrome; CRC trans rs7824557 0.564 rs2736295 chr8:11234780 C/G cg06636001 chr8:8085503 FLJ10661 0.45 6.93 0.36 2.16e-11 Retinal vascular caliber; CRC cis rs9467773 0.967 rs6456732 chr6:26514445 T/C cg09904177 chr6:26538194 HMGN4 0.86 14.77 0.63 3.09e-38 Intelligence (multi-trait analysis); CRC cis rs7309 0.810 rs11684253 chr2:162034536 G/T cg08807892 chr2:162101083 NA 0.46 6.7 0.35 9e-11 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Educational attainment; CRC cis rs9322193 0.962 rs3763163 chr6:150140906 G/T cg05861140 chr6:150128134 PCMT1 -0.41 -6.56 -0.34 2.13e-10 Lung cancer; CRC cis rs4319547 0.695 rs6489002 chr12:122929822 T/C cg05707623 chr12:122985044 ZCCHC8 -0.75 -9.27 -0.46 2.46e-18 Body mass index; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg07869135 chr8:123794843 ZHX2 0.46 6.08 0.32 3.25e-9 Thyroid stimulating hormone; CRC cis rs7772486 0.806 rs2253648 chr6:146199296 G/A cg23711669 chr6:146136114 FBXO30 0.69 11.81 0.55 4.62e-27 Lobe attachment (rater-scored or self-reported); CRC cis rs1538970 1.000 rs9326141 chr1:45828943 A/G cg05343316 chr1:45956843 TESK2 -0.68 -8.95 -0.44 2.72e-17 Platelet count; CRC cis rs798554 0.757 rs2644312 chr7:2841164 G/A cg13628971 chr7:2884303 GNA12 0.53 7.3 0.37 2.12e-12 Height; CRC cis rs7827545 0.545 rs16905172 chr8:135556373 A/G cg17885191 chr8:135476712 NA 0.64 7.85 0.4 6.08e-14 Hypertension (SNP x SNP interaction); CRC cis rs1572438 1.000 rs9328455 chr6:864095 C/T cg21062780 chr6:887772 NA -0.39 -5.96 -0.31 6.47e-9 Aging; CRC cis rs2635047 0.967 rs2576060 chr18:44637106 C/T cg23996704 chr18:44553084 KATNAL2 0.32 6.4 0.33 5.31e-10 Educational attainment; CRC cis rs6502050 0.835 rs10163496 chr17:80110867 G/A cg02741985 chr17:80059408 CCDC57 0.43 7.15 0.37 5.66e-12 Life satisfaction; CRC cis rs9611565 0.546 rs739129 chr22:42118249 G/A cg06634786 chr22:41940651 POLR3H 0.64 7.32 0.37 1.94e-12 Vitiligo; CRC cis rs7647973 1.000 rs6446268 chr3:49445695 G/A cg07636037 chr3:49044803 WDR6 -0.63 -7.47 -0.38 7.16e-13 Menarche (age at onset); CRC cis rs9311474 0.508 rs6805156 chr3:52609362 T/C cg18099408 chr3:52552593 STAB1 -0.46 -7.97 -0.4 2.56e-14 Electroencephalogram traits; CRC cis rs6540559 0.611 rs11810817 chr1:210011747 C/G cg22029157 chr1:209979665 IRF6 0.62 7.4 0.38 1.18e-12 Cleft lip with or without cleft palate; CRC cis rs7551222 0.716 rs10494852 chr1:204457786 A/G cg07972458 chr1:204535000 NA -0.36 -5.74 -0.3 2.11e-8 Schizophrenia; CRC cis rs6912958 0.712 rs4587138 chr6:88356915 G/C cg08069147 chr6:88032118 GJB7;C6orf162 -0.56 -8.41 -0.42 1.23e-15 Monocyte percentage of white cells; CRC cis rs7786808 0.564 rs10267128 chr7:158198490 G/A cg09998033 chr7:158218633 PTPRN2 0.52 7.29 0.37 2.29e-12 Obesity-related traits; CRC cis rs16924133 0.793 rs16923830 chr11:33136437 T/C cg05567920 chr11:33183001 CSTF3 -0.78 -5.92 -0.31 7.95e-9 Anger; CRC cis rs10883723 0.810 rs7094366 chr10:104274730 C/G cg04362960 chr10:104952993 NT5C2 -0.43 -6.02 -0.32 4.55e-9 Allergic disease (asthma, hay fever or eczema); CRC cis rs2976388 1.000 rs2920294 chr8:143765326 C/G cg04969067 chr8:143858791 LYNX1 -0.36 -6.07 -0.32 3.58e-9 Urinary tract infection frequency; CRC cis rs72634258 0.842 rs7545677 chr1:8165619 C/T cg26816564 chr1:7831052 VAMP3 0.53 6.38 0.33 5.93e-10 Inflammatory bowel disease; CRC trans rs12699921 0.632 rs2691615 chr7:17887180 C/G cg15753394 chr6:17282781 RBM24 -0.36 -6.12 -0.32 2.69e-9 Fibrinogen levels; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg12713142 chr12:57081325 PTGES3 0.48 6.83 0.35 4.02e-11 Response to antipsychotic treatment; CRC cis rs6964587 1.000 rs416 chr7:91580571 A/G cg17063962 chr7:91808500 NA -0.79 -13.81 -0.61 1.52e-34 Breast cancer; CRC cis rs1552244 1.000 rs34179822 chr3:10140017 A/G cg16606324 chr3:10149918 C3orf24 0.69 9.75 0.47 6.97e-20 Alzheimer's disease; CRC cis rs9443645 0.868 rs9443643 chr6:79798838 A/G cg09184832 chr6:79620586 NA -0.49 -8.97 -0.44 2.25e-17 Intelligence (multi-trait analysis); CRC cis rs2463822 0.583 rs7104825 chr11:62026833 C/T cg06239285 chr11:62104954 ASRGL1 -0.6 -5.9 -0.31 9.15e-9 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs7044106 0.537 rs10818474 chr9:123489964 C/T cg14255062 chr9:123606675 PSMD5;LOC253039 0.42 5.75 0.3 1.99e-8 Hip circumference adjusted for BMI; CRC cis rs7666738 0.830 rs11942114 chr4:99066261 C/G cg17366294 chr4:99064904 C4orf37 0.42 7.04 0.36 1.15e-11 Colonoscopy-negative controls vs population controls; CRC cis rs1862618 0.853 rs9283717 chr5:56078659 G/A cg03609598 chr5:56110824 MAP3K1 -0.83 -9.86 -0.48 2.95e-20 Initial pursuit acceleration; CRC cis rs9300255 0.722 rs1060105 chr12:123806219 C/T cg00376283 chr12:123451042 ABCB9 -0.55 -6.49 -0.34 3.21e-10 Neutrophil percentage of white cells; CRC cis rs9534288 0.797 rs9534279 chr13:46584999 T/C cg15192986 chr13:46630673 CPB2 -0.67 -9.85 -0.48 3.16e-20 Blood protein levels; CRC trans rs7615952 0.932 rs13086087 chr3:125646281 A/C cg16558177 chr4:4109446 NA -0.47 -6.04 -0.32 4.22e-9 Blood pressure (smoking interaction); CRC cis rs200986 1 rs200986 chr6:27824766 G/C cg21251018 chr6:28226885 NKAPL 0.51 7.86 0.4 5.51e-14 Autism spectrum disorder or schizophrenia; CRC cis rs769267 0.930 rs10419912 chr19:19597055 A/G cg03709012 chr19:19516395 GATAD2A -0.72 -11.17 -0.52 9.27e-25 Tonsillectomy; CRC trans rs1814175 0.509 rs60698301 chr11:49877672 G/A cg15704280 chr7:45808275 SEPT13 -0.93 -16.5 -0.67 5.24e-45 Height; CRC cis rs9292777 0.901 rs6878213 chr5:40433576 C/T cg09067459 chr5:40385259 NA 0.51 8.87 0.44 4.77e-17 Crohn's disease;Multiple sclerosis; CRC cis rs1008375 1.000 rs10012335 chr4:17628630 C/G cg16339924 chr4:17578868 LAP3 0.53 7.16 0.37 5.38e-12 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs13108904 0.870 rs2291199 chr4:1244267 A/G cg20092199 chr4:1342459 KIAA1530 0.34 5.78 0.3 1.74e-8 Obesity-related traits; CRC trans rs941898 0.574 rs8006662 chr14:100577890 C/T cg10265472 chr16:20753215 THUMPD1 0.68 6.13 0.32 2.49e-9 White matter hyperintensity burden; CRC cis rs1580019 0.520 rs13228793 chr7:32711465 C/T cg07520158 chr7:32535189 LSM5;AVL9 0.44 5.79 0.3 1.65e-8 Cognitive ability; CRC cis rs55702914 0.935 rs17405525 chr2:198214183 C/G cg10820045 chr2:198174542 NA -0.35 -6.23 -0.32 1.43e-9 Major depression and alcohol dependence; CRC trans rs2303319 0.504 rs56965753 chr2:162597251 A/G cg27342122 chr8:133787442 PHF20L1 -0.72 -6.12 -0.32 2.68e-9 Cognitive function; CRC cis rs11148252 0.574 rs2038826 chr13:53280013 G/A cg00495681 chr13:53174319 NA 0.84 15.08 0.64 1.91e-39 Lewy body disease; CRC cis rs11122272 0.525 rs61835222 chr1:231537917 C/A cg06096015 chr1:231504339 EGLN1 0.39 5.86 0.31 1.15e-8 Hemoglobin concentration; CRC cis rs7605827 0.897 rs7567750 chr2:15690412 C/T cg19274914 chr2:15703543 NA 0.39 5.82 0.31 1.4e-8 Educational attainment (years of education); CRC cis rs9926296 0.585 rs6500441 chr16:89828669 C/G cg04287289 chr16:89883240 FANCA 0.63 10.5 0.5 1.89e-22 Vitiligo; CRC cis rs13108904 0.870 rs11721789 chr4:1254414 C/A cg20092199 chr4:1342459 KIAA1530 0.34 5.9 0.31 8.88e-9 Obesity-related traits; CRC cis rs394563 0.967 rs438852 chr6:149794533 C/T cg03678062 chr6:149772716 ZC3H12D 0.34 6.05 0.32 4e-9 Dupuytren's disease; CRC cis rs807029 0.533 rs3824783 chr10:102750851 C/T cg04662943 chr10:102668895 NA 0.59 7.21 0.37 3.94e-12 Ejection fraction in Tripanosoma cruzi seropositivity; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg12813709 chr11:576467 PHRF1;LOC143666 -0.39 -6.02 -0.31 4.78e-9 Myopia (pathological); CRC cis rs898097 0.805 rs60233158 chr17:80896612 A/G cg19046167 chr17:80928561 B3GNTL1 0.45 6.99 0.36 1.58e-11 Breast cancer; CRC cis rs2777491 0.874 rs28716108 chr15:41655523 G/C cg18705301 chr15:41695430 NDUFAF1 -0.74 -12.3 -0.56 7.15e-29 Ulcerative colitis; CRC cis rs35110281 0.748 rs9981460 chr21:45030965 T/A cg01579765 chr21:45077557 HSF2BP -0.38 -7.36 -0.38 1.46e-12 Mean corpuscular volume; CRC trans rs10090774 0.965 rs4246123 chr8:141775168 C/A cg15523980 chr1:234136308 SLC35F3 0.4 5.97 0.31 6.02e-9 Acute graft versus host disease in bone marrow transplantation (recipient effect); CRC cis rs853679 1.000 rs735765 chr6:28170297 G/A cg03623178 chr6:28175578 NA 0.88 8.56 0.43 4.34e-16 Depression; CRC cis rs1153858 1.000 rs10519022 chr15:45663684 C/T cg21132104 chr15:45694354 SPATA5L1 -0.58 -8.61 -0.43 3.07e-16 Homoarginine levels; CRC cis rs9914988 0.943 rs9890377 chr17:27111111 A/G cg12682573 chr17:27188876 MIR451;MIR144 0.58 7.99 0.4 2.37e-14 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs73206853 0.619 rs112148402 chr12:111171493 T/C cg12870014 chr12:110450643 ANKRD13A 0.76 7.9 0.4 4.34e-14 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC cis rs17270561 0.666 rs9356987 chr6:25739187 C/A cg17691542 chr6:26056736 HIST1H1C 0.73 9.26 0.45 2.71e-18 Iron status biomarkers; CRC cis rs7786808 0.649 rs1377374 chr7:158215647 G/T cg01191920 chr7:158217561 PTPRN2 0.61 10.1 0.49 4.57e-21 Obesity-related traits; CRC cis rs4713118 0.588 rs200994 chr6:27813813 A/C cg03623178 chr6:28175578 NA -0.78 -10.39 -0.5 4.59e-22 Parkinson's disease; CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg06530742 chr19:41223047 ITPKC;ADCK4 0.42 6.56 0.34 2.15e-10 Obesity-related traits; CRC cis rs6546550 0.901 rs6729760 chr2:70161032 C/T cg02498382 chr2:70120550 SNRNP27 -0.55 -9.28 -0.46 2.4e-18 Prevalent atrial fibrillation; CRC cis rs6500602 0.702 rs56895104 chr16:4548132 G/A cg14951292 chr16:4525986 HMOX2;NMRAL1 0.58 8.83 0.44 6.42e-17 Schizophrenia; CRC cis rs7618501 0.633 rs6446189 chr3:50008566 A/G cg24110177 chr3:50126178 RBM5 -0.46 -6.84 -0.35 3.94e-11 Intelligence (multi-trait analysis); CRC cis rs9487051 1.000 rs9374080 chr6:109616420 C/T cg12927641 chr6:109611667 NA 0.33 5.69 0.3 2.77e-8 Reticulocyte fraction of red cells; CRC cis rs2836974 0.932 rs11910151 chr21:40560262 T/C cg06238570 chr21:40685208 BRWD1 0.74 10.48 0.5 2.32e-22 Cognitive function; CRC cis rs10911232 0.507 rs35782443 chr1:183051502 A/C ch.1.3577855R chr1:183094577 LAMC1 0.82 14.22 0.62 4.28e-36 Hypertriglyceridemia; CRC cis rs6815814 0.950 rs5743556 chr4:38806851 A/G cg06935464 chr4:38784597 TLR10 0.57 5.97 0.31 6.19e-9 Breast cancer; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg07417863 chr1:120396167 NA -0.4 -6.47 -0.34 3.53e-10 Liver disease severity in Alagille syndrome; CRC cis rs35883536 0.967 rs4991930 chr1:101122755 T/C cg14515779 chr1:101123966 NA -0.43 -8.29 -0.42 2.84e-15 Monocyte count; CRC cis rs910316 0.737 rs175072 chr14:75502827 T/C cg11812906 chr14:75593930 NEK9 -0.57 -8.95 -0.44 2.69e-17 Height; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg17465063 chr10:111985564 MXI1 0.44 6.93 0.36 2.22e-11 Intelligence (multi-trait analysis); CRC cis rs1059312 0.808 rs4482069 chr12:129294252 G/C cg09035930 chr12:129282057 SLC15A4 0.53 8.91 0.44 3.47e-17 Systemic lupus erythematosus; CRC cis rs9788333 0.762 rs4441120 chr13:21886863 T/A cg25811766 chr13:21894605 NA 0.69 10.97 0.52 4.66e-24 Thiazide-induced adverse metabolic effects in hypertensive patients; CRC cis rs11212617 1.000 rs11212619 chr11:108289167 A/G cg12106634 chr11:108092400 ATM;NPAT 0.41 6.08 0.32 3.34e-9 Response to metformin in type 2 diabetes (glycemic); CRC trans rs6703335 0.870 rs10803142 chr1:243598234 A/G cg11907262 chr19:34310911 NA 0.43 6.25 0.33 1.26e-9 Schizophrenia;Schizophrenia, schizoaffective disorder or bipolar disorder; CRC trans rs7395662 0.571 rs10838947 chr11:48568693 G/T cg15704280 chr7:45808275 SEPT13 -0.48 -6.83 -0.35 4.04e-11 HDL cholesterol; CRC cis rs4319547 0.876 rs10846978 chr12:122964708 T/C cg05707623 chr12:122985044 ZCCHC8 -0.8 -10.03 -0.48 7.97e-21 Body mass index; CRC cis rs7465272 0.500 rs7463655 chr8:143731034 G/C cg10596483 chr8:143751796 JRK 0.48 6.49 0.34 3.23e-10 Bipolar disorder and schizophrenia; CRC cis rs6951245 1.000 rs884977 chr7:1066410 T/C cg26224354 chr7:1096374 C7orf50;GPR146 -0.65 -9.23 -0.45 3.31e-18 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs4728142 0.604 rs10954215 chr7:128645513 T/C cg06630958 chr7:128577819 IRF5 -0.35 -5.73 -0.3 2.26e-8 Inflammatory bowel disease;Systemic lupus erythematosus;Ulcerative colitis; CRC cis rs9768139 0.903 rs28503558 chr7:158119568 C/T cg25566285 chr7:158114605 PTPRN2 -0.58 -9.92 -0.48 1.88e-20 Calcium levels; CRC cis rs7945705 0.967 rs10769968 chr11:8907583 G/C cg12365402 chr11:9010492 NRIP3 0.47 7.75 0.39 1.18e-13 Hemoglobin concentration; CRC cis rs546131 0.928 rs552868 chr11:34830694 G/A cg11058730 chr11:34937778 PDHX;APIP 0.48 7.05 0.36 1.06e-11 Lung disease severity in cystic fibrosis; CRC cis rs881375 0.967 rs7039505 chr9:123705945 A/T cg09586646 chr9:123605570 PSMD5;LOC253039 0.46 6.34 0.33 7.67e-10 Rheumatoid arthritis; CRC cis rs9814567 0.752 rs9846111 chr3:134335034 T/C cg06109529 chr3:134205091 CEP63;ANAPC13 -0.67 -9.7 -0.47 9.73e-20 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs9660180 1.000 rs9660180 chr1:1723031 G/A cg17747265 chr1:1875780 NA -0.74 -12.84 -0.58 7.27e-31 Body mass index; CRC cis rs1348850 0.519 rs4144275 chr2:178523368 C/T cg22681709 chr2:178499509 PDE11A -0.41 -7.51 -0.38 5.71e-13 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs11098499 0.913 rs35271032 chr4:120156659 C/T cg24375607 chr4:120327624 NA 0.44 6.83 0.35 4.17e-11 Corneal astigmatism; CRC cis rs7666738 0.830 rs17550735 chr4:99014076 T/G cg17366294 chr4:99064904 C4orf37 0.44 7.35 0.38 1.55e-12 Colonoscopy-negative controls vs population controls; CRC cis rs4862750 0.914 rs10027250 chr4:187873460 T/C cg27532560 chr4:187881888 NA -0.55 -9.97 -0.48 1.28e-20 Lobe attachment (rater-scored or self-reported); CRC cis rs10779751 1.000 rs11121698 chr1:11267283 C/T cg08854313 chr1:11322531 MTOR 0.77 12.05 0.55 6.12e-28 Body mass index; CRC cis rs6951245 0.872 rs11768486 chr7:1101290 C/A cg04025307 chr7:1156635 C7orf50 0.64 6.81 0.35 4.53e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs9916302 0.904 rs801420 chr17:37466103 C/G cg15445000 chr17:37608096 MED1 -0.42 -9.22 -0.45 3.61e-18 Glomerular filtration rate (creatinine); CRC cis rs910187 0.641 rs3818011 chr20:45816566 A/G cg27589058 chr20:45804311 EYA2 -0.39 -7.51 -0.38 5.63e-13 Migraine; CRC cis rs9303280 0.901 rs9901146 chr17:38043343 G/A cg11212589 chr17:38028394 ZPBP2 0.47 8.83 0.44 6.39e-17 Self-reported allergy; CRC cis rs6088590 0.735 rs2273684 chr20:33529766 G/T cg24642439 chr20:33292090 TP53INP2 -0.38 -6.46 -0.34 3.81e-10 Coronary artery disease; CRC trans rs33794 0.577 rs245214 chr3:45241622 C/G cg00688460 chr12:48922396 NA 0.27 5.97 0.31 6.06e-9 Lung function (forced expiratory volume in 1 second); CRC cis rs2281845 0.965 rs3738262 chr1:201083343 A/G cg08885800 chr1:201084119 NA 0.49 9.02 0.45 1.55e-17 Permanent tooth development; CRC cis rs4862750 0.872 rs6811569 chr4:187897988 A/G cg27532560 chr4:187881888 NA 0.54 9.71 0.47 9.39e-20 Lobe attachment (rater-scored or self-reported); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg14022721 chr22:25507536 KIAA1671 0.45 6.61 0.34 1.52e-10 Response to antipsychotic treatment; CRC cis rs875971 0.540 rs781152 chr7:65479572 T/A cg00343986 chr7:65444356 GUSB 0.53 7.66 0.39 2.12e-13 Aortic root size; CRC cis rs10540 1.000 rs35811812 chr11:498442 G/A cg03934478 chr11:495069 RNH1 0.71 8.6 0.43 3.27e-16 Body mass index; CRC cis rs3862260 0.509 rs1045827 chr1:120162442 C/T cg16322792 chr1:120165303 ZNF697 -0.46 -8.16 -0.41 7.06e-15 Systemic lupus erythematosus; CRC cis rs12791968 1.000 rs11038240 chr11:45002878 A/G cg11846598 chr11:44996168 LOC221122 0.74 13.25 0.59 2.05e-32 Inhibitory control; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg02895995 chr19:7554069 PEX11G 0.47 6.71 0.35 8.29e-11 Response to antipsychotic treatment; CRC cis rs10540 0.915 rs12419209 chr11:494510 T/C cg19913688 chr11:428466 ANO9 -0.7 -7.21 -0.37 3.76e-12 Body mass index; CRC trans rs11148252 0.875 rs4885953 chr13:52976491 G/A cg18335740 chr13:41363409 SLC25A15 0.46 7.18 0.37 4.61e-12 Lewy body disease; CRC cis rs3936840 1.000 rs3936840 chr14:102984274 G/C cg18135206 chr14:102964638 TECPR2 0.57 8.05 0.41 1.53e-14 Plateletcrit; CRC cis rs61160187 0.582 rs12655209 chr5:60306052 C/T cg16298547 chr5:60138761 ELOVL7 0.27 5.83 0.31 1.31e-8 Educational attainment (years of education);Educational attainment (college completion); CRC cis rs769267 0.930 rs3752151 chr19:19616026 T/C cg01262667 chr19:19385393 TM6SF2 0.36 5.86 0.31 1.11e-8 Tonsillectomy; CRC cis rs8060686 0.641 rs113258243 chr16:68086656 C/T cg08314208 chr16:67682810 RLTPR -0.63 -6.75 -0.35 6.58e-11 HDL cholesterol;Metabolic syndrome; CRC cis rs7666738 0.578 rs1989109 chr4:98881246 T/A cg17366294 chr4:99064904 C4orf37 0.42 6.9 0.36 2.61e-11 Colonoscopy-negative controls vs population controls; CRC cis rs12594515 0.967 rs11070466 chr15:45984955 C/T cg01629716 chr15:45996671 NA 0.41 8.51 0.42 6.27e-16 Waist circumference;Weight; CRC cis rs10504229 1.000 rs58371676 chr8:58189382 G/A cg02725872 chr8:58115012 NA -0.38 -6.43 -0.33 4.44e-10 Developmental language disorder (linguistic errors); CRC cis rs10512697 0.655 rs13157404 chr5:3473854 C/T cg19473799 chr5:3511975 NA -0.83 -6.35 -0.33 7.32e-10 Immune response to smallpox vaccine (IL-6); CRC cis rs79149102 0.579 rs7173218 chr15:75315328 A/G cg09165964 chr15:75287851 SCAMP5 -0.61 -6.08 -0.32 3.32e-9 Lung cancer; CRC cis rs11677416 0.885 rs4849119 chr2:113523463 G/C cg27083787 chr2:113543245 IL1A 0.49 6.88 0.35 3.07e-11 Response to antipsychotic treatment in schizophrenia (working memory); CRC cis rs9635542 0.833 rs73522915 chr16:5007440 T/C cg06510647 chr16:5006106 NA -0.61 -6.67 -0.34 1.1e-10 Lung cancer (asbestos exposure interaction);Cancer; CRC cis rs3806843 0.576 rs246028 chr5:140333513 C/T cg19875535 chr5:140030758 IK 0.4 6.12 0.32 2.64e-9 Depressive symptoms (multi-trait analysis); CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg15021585 chr13:21099875 CRYL1 0.44 6.35 0.33 7.01e-10 Anxiety disorder; CRC trans rs116095464 0.558 rs10077076 chr5:231940 C/T cg00938859 chr5:1591904 SDHAP3 0.69 7.58 0.39 3.49e-13 Breast cancer; CRC cis rs6502050 0.799 rs58538819 chr17:80107153 G/C cg25804541 chr17:80189381 SLC16A3 -0.32 -6.13 -0.32 2.55e-9 Life satisfaction; CRC cis rs13256369 1.000 rs873063 chr8:8572447 A/G cg06636001 chr8:8085503 FLJ10661 0.46 5.82 0.31 1.38e-8 Obesity-related traits; CRC cis rs10751667 0.666 rs6597967 chr11:950583 G/T ch.11.42038R chr11:967971 AP2A2 0.59 10.18 0.49 2.44e-21 Alzheimer's disease (late onset); CRC cis rs11190604 1.000 rs2489049 chr10:102350732 G/A cg07080220 chr10:102295463 HIF1AN 0.48 6.06 0.32 3.66e-9 Palmitoleic acid (16:1n-7) levels; CRC cis rs7666738 0.606 rs10006414 chr4:99101401 T/C cg05340658 chr4:99064831 C4orf37 0.47 6.83 0.35 4.08e-11 Colonoscopy-negative controls vs population controls; CRC cis rs9488822 0.596 rs13206506 chr6:116324460 A/G cg15226275 chr6:116381976 FRK 0.3 7.85 0.4 5.89e-14 Cholesterol, total;LDL cholesterol; CRC cis rs3736485 0.934 rs7170330 chr15:51859313 C/T cg08986416 chr15:51914746 DMXL2 -0.45 -6.56 -0.34 2.12e-10 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs6570726 0.791 rs11155433 chr6:145907831 A/G cg05347473 chr6:146136440 FBXO30 -0.39 -5.92 -0.31 7.91e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs736408 0.505 rs2083180 chr3:52668119 G/T cg10802521 chr3:52805072 NEK4 -0.56 -8.92 -0.44 3.39e-17 Bipolar disorder; CRC cis rs7914558 0.966 rs746293 chr10:104897254 G/T cg15744005 chr10:104629667 AS3MT -0.34 -7.27 -0.37 2.57e-12 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs13064411 0.696 rs9869318 chr3:113146271 T/C cg10517650 chr3:113235015 CCDC52 -0.38 -6.08 -0.32 3.42e-9 Response to simvastatin treatment (PCSK9 protein level change); CRC cis rs78456975 1.000 rs10205916 chr2:1558451 A/T cg12573674 chr2:1569213 NA 0.74 7.66 0.39 2.17e-13 Placebo response in major depressive disorder (% change in symptom score); CRC cis rs13108904 0.967 rs12642396 chr4:1293055 C/A cg02018176 chr4:1364513 KIAA1530 0.47 7.7 0.39 1.56e-13 Obesity-related traits; CRC cis rs9379832 1 rs9379832 chr6:26186200 A/G cg00631329 chr6:26305371 NA -0.48 -7.48 -0.38 6.82e-13 Birth weight; CRC cis rs860295 0.702 rs12081067 chr1:155358982 A/G cg02153340 chr1:155202674 NA -0.57 -6.77 -0.35 5.96e-11 Body mass index; CRC cis rs9611565 0.512 rs4820444 chr22:42202606 A/G cg17554472 chr22:41940697 POLR3H 0.54 5.72 0.3 2.44e-8 Vitiligo; CRC cis rs7394190 0.748 rs4746147 chr10:75527708 A/G cg07699608 chr10:75541558 CHCHD1 0.6 6.34 0.33 7.42e-10 Incident atrial fibrillation; CRC cis rs7666738 0.830 rs1527517 chr4:98931907 C/T cg17366294 chr4:99064904 C4orf37 0.43 7.32 0.37 1.95e-12 Colonoscopy-negative controls vs population controls; CRC cis rs904251 0.523 rs1776454 chr6:37482099 C/T cg01843034 chr6:37503916 NA -0.43 -8.16 -0.41 7.32e-15 Cognitive performance; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg11164639 chr15:91192950 NA 0.39 6.34 0.33 7.63e-10 Intelligence (multi-trait analysis); CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg25375453 chr3:14219857 LSM3;XPC 0.44 6.3 0.33 9.52e-10 Anxiety disorder; CRC trans rs2228479 0.850 rs62054609 chr16:89816569 C/A cg21302420 chr1:112162376 RAP1A 0.72 6.01 0.31 5.05e-9 Skin colour saturation; CRC cis rs270601 0.633 rs733300 chr5:131572243 A/G cg02033258 chr5:131593261 PDLIM4 0.49 8.67 0.43 1.97e-16 Acylcarnitine levels; CRC cis rs7949030 0.596 rs11231138 chr11:62316195 C/G cg11742103 chr11:62369870 EML3;MTA2 0.63 12.04 0.55 6.54e-28 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; CRC cis rs7584330 0.518 rs7585975 chr2:238439089 G/A cg08992911 chr2:238395768 MLPH 0.59 6.11 0.32 2.82e-9 Prostate cancer; CRC cis rs7589728 0.925 rs78829281 chr2:88502293 T/A cg04511125 chr2:88470314 THNSL2 0.66 6.47 0.34 3.48e-10 Plasma clusterin levels; CRC cis rs73206853 0.764 rs16940935 chr12:111107470 A/G cg12870014 chr12:110450643 ANKRD13A 0.86 9.77 0.47 5.65e-20 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC cis rs9905704 0.914 rs2611777 chr17:56826958 A/G cg12560992 chr17:57184187 TRIM37 0.53 7.29 0.37 2.33e-12 Testicular germ cell tumor; CRC cis rs801193 0.569 rs2659907 chr7:66164032 G/A cg00343986 chr7:65444356 GUSB 0.45 6.27 0.33 1.12e-9 Aortic root size; CRC cis rs9322193 0.923 rs9505823 chr6:149950035 A/C cg05861140 chr6:150128134 PCMT1 -0.35 -5.74 -0.3 2.1e-8 Lung cancer; CRC cis rs4713118 0.527 rs9461433 chr6:28095172 C/T cg02683197 chr6:28174875 NA 0.85 10.52 0.5 1.71e-22 Parkinson's disease; CRC cis rs9896052 0.559 rs7220850 chr17:73436994 T/C cg25649188 chr17:73499917 CASKIN2 0.63 6.35 0.33 7.18e-10 Sight-threatening diabetic retinopathy in type 2 diabetes; CRC cis rs853679 0.546 rs200995 chr6:27813694 C/T cg06470822 chr6:28175283 NA -0.66 -5.61 -0.3 4.35e-8 Depression; CRC cis rs875971 0.862 rs11984115 chr7:65773859 C/T cg00343986 chr7:65444356 GUSB -0.45 -6.25 -0.33 1.27e-9 Aortic root size; CRC cis rs4713118 0.824 rs9468225 chr6:27745719 T/G cg06470822 chr6:28175283 NA 0.76 10.12 0.49 3.9e-21 Parkinson's disease; CRC cis rs7786808 0.544 rs6971888 chr7:158193835 G/A cg17401720 chr7:158221031 PTPRN2 -0.39 -6.43 -0.33 4.57e-10 Obesity-related traits; CRC cis rs11792861 0.781 rs838835 chr9:111758590 A/G cg14432460 chr9:111696404 IKBKAP;C9orf6 -0.45 -5.95 -0.31 6.89e-9 Menarche (age at onset); CRC cis rs7212590 0.655 rs56198517 chr17:57976582 G/T cg10252138 chr17:58120427 NA -0.6 -6.09 -0.32 3.21e-9 Granulocyte percentage of myeloid white cells;Monocyte count;Monocyte percentage of white cells; CRC cis rs1046896 1.000 rs1046896 chr17:80685533 A/G cg19500275 chr17:80737654 TBCD -0.4 -6.03 -0.32 4.46e-9 Glycated hemoglobin levels; CRC cis rs6546324 0.559 rs11126134 chr2:67781064 G/T cg15745817 chr2:67799979 NA 0.48 7.84 0.4 6.53e-14 Endometriosis; CRC cis rs9303401 0.659 rs56162835 chr17:56687315 A/G cg10487724 chr17:56770010 TEX14;RAD51C 0.79 9.65 0.47 1.44e-19 Cognitive test performance; CRC cis rs7178572 0.539 rs12594346 chr15:77671966 A/T cg22256960 chr15:77711686 NA 0.6 7.17 0.37 5.13e-12 Type 2 diabetes; CRC trans rs7647973 0.626 rs11720705 chr3:49753788 A/G cg21659725 chr3:3221576 CRBN -0.66 -7.52 -0.38 5.11e-13 Menarche (age at onset); CRC cis rs10046574 0.831 rs10278289 chr7:135089662 A/G cg27474649 chr7:135195673 CNOT4 0.63 5.67 0.3 3.07e-8 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs7666738 0.830 rs1111541 chr4:99033860 A/G cg05340658 chr4:99064831 C4orf37 -0.61 -9.39 -0.46 1.06e-18 Colonoscopy-negative controls vs population controls; CRC trans rs941408 0.515 rs1640262 chr19:2779134 C/T cg22153745 chr1:153894579 GATAD2B 0.52 7.31 0.37 2.04e-12 Total cholesterol levels; CRC cis rs2836974 0.563 rs997147 chr21:40695325 A/G cg06238570 chr21:40685208 BRWD1 -0.8 -12.62 -0.57 4.92e-30 Cognitive function; CRC cis rs6952808 0.609 rs12699453 chr7:1953056 C/T cg22963979 chr7:1858916 MAD1L1 -0.43 -6.8 -0.35 4.86e-11 Bipolar disorder and schizophrenia; CRC cis rs875971 0.929 rs778692 chr7:65872449 A/G cg00343986 chr7:65444356 GUSB 0.43 6.3 0.33 9.66e-10 Aortic root size; CRC cis rs2797160 0.602 rs4897150 chr6:125985540 C/T cg05901451 chr6:126070800 HEY2 -0.36 -5.71 -0.3 2.53e-8 Endometrial cancer; CRC cis rs9611565 0.592 rs5751139 chr22:42099981 G/C cg03806693 chr22:41940476 POLR3H 1.06 13.39 0.59 6.38e-33 Vitiligo; CRC cis rs2408955 0.521 rs7301003 chr12:48550227 A/G cg21466736 chr12:48725269 NA -0.48 -7.35 -0.38 1.54e-12 Glycated hemoglobin levels; CRC trans rs2727020 0.521 rs7101761 chr11:49598178 G/A cg11707556 chr5:10655725 ANKRD33B -0.48 -7.68 -0.39 1.87e-13 Coronary artery disease; CRC cis rs9818758 0.556 rs9872660 chr3:49378832 G/T cg00383909 chr3:49044727 WDR6 0.72 7.36 0.38 1.52e-12 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; CRC cis rs6089584 0.566 rs11699442 chr20:60623268 A/G cg13770153 chr20:60521292 NA -0.44 -6.66 -0.34 1.17e-10 Body mass index; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg04056875 chr12:50101363 FMNL3 0.43 6.23 0.32 1.43e-9 Intelligence (multi-trait analysis); CRC cis rs7666738 0.830 rs7697315 chr4:98938764 T/C cg05340658 chr4:99064831 C4orf37 0.57 8.67 0.43 2.01e-16 Colonoscopy-negative controls vs population controls; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg05134831 chr1:36621785 MAP7D1 0.36 6.34 0.33 7.66e-10 Liver disease severity in Alagille syndrome; CRC cis rs28386778 0.863 rs3760252 chr17:61852186 G/C cg11494091 chr17:61959527 GH2 0.6 10.07 0.49 5.87e-21 Prudent dietary pattern; CRC cis rs1153858 0.887 rs28569043 chr15:45730926 A/T cg10760299 chr15:45669010 GATM 0.44 6.76 0.35 6.16e-11 Homoarginine levels; CRC cis rs1150668 0.835 rs1233696 chr6:28143010 T/C cg12172441 chr6:28176163 NA 0.45 6.55 0.34 2.25e-10 Pubertal anthropometrics; CRC cis rs1707322 0.686 rs2991986 chr1:46081282 A/G cg03146154 chr1:46216737 IPP -0.67 -9.43 -0.46 7.54e-19 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs9296092 0.538 rs7761268 chr6:33519300 C/T cg13560919 chr6:33536144 NA -0.45 -6.28 -0.33 1.07e-9 Age at smoking initiation in chronic obstructive pulmonary disease; CRC cis rs12024301 0.557 rs78503512 chr1:183643289 G/A cg11505048 chr1:183622726 RGL1;APOBEC4 0.81 7.06 0.36 1.01e-11 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs727563 0.552 rs4822045 chr22:41985958 C/A cg03806693 chr22:41940476 POLR3H -1.04 -11.6 -0.54 2.54e-26 Crohn's disease;Inflammatory bowel disease; CRC cis rs9322193 0.962 rs9689269 chr6:150112997 G/A cg00933542 chr6:150070202 PCMT1 0.28 5.63 0.3 3.86e-8 Lung cancer; CRC cis rs929596 0.564 rs2741030 chr2:234536152 C/T cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.43 -5.7 -0.3 2.62e-8 Total bilirubin levels in HIV-1 infection; CRC cis rs1552244 0.554 rs2272122 chr3:10047975 C/G cg00166722 chr3:10149974 C3orf24 0.43 6.26 0.33 1.22e-9 Alzheimer's disease; CRC cis rs12142240 0.698 rs41293285 chr1:46808426 C/T cg00530320 chr1:46809349 NSUN4 0.58 7.98 0.4 2.46e-14 Menopause (age at onset); CRC trans rs61931739 0.500 rs3924705 chr12:34557825 A/T cg13010199 chr12:38710504 ALG10B 0.46 6.57 0.34 2.02e-10 Morning vs. evening chronotype; CRC cis rs1046896 0.552 rs12602280 chr17:80805421 G/C cg03160526 chr17:80928410 B3GNTL1 0.57 7.43 0.38 9.46e-13 Glycated hemoglobin levels; CRC cis rs2576037 0.583 rs2187091 chr18:44520048 T/C cg23996704 chr18:44553084 KATNAL2 -0.39 -7.69 -0.39 1.7e-13 Personality dimensions; CRC cis rs6502050 0.835 rs8065981 chr17:80091393 G/T cg19223190 chr17:80058835 NA 0.39 6.32 0.33 8.75e-10 Life satisfaction; CRC cis rs2180341 0.782 rs6912750 chr6:127723081 A/T cg27446573 chr6:127587934 RNF146 0.72 10.03 0.48 8.03e-21 Breast cancer; CRC cis rs7044106 0.762 rs10984974 chr9:123421556 C/T cg09586646 chr9:123605570 PSMD5;LOC253039 0.61 8.99 0.44 1.94e-17 Hip circumference adjusted for BMI; CRC cis rs853679 0.517 rs9468292 chr6:28095355 G/A cg02631126 chr6:28058918 ZSCAN12L1 0.29 5.89 0.31 9.41e-9 Depression; CRC cis rs2404602 0.583 rs12898415 chr15:76574232 C/T cg00316803 chr15:76480434 C15orf27 -0.4 -6.92 -0.36 2.36e-11 Blood metabolite levels; CRC cis rs2742417 1.000 rs1877934 chr3:45753295 G/A cg04837898 chr3:45731254 SACM1L -0.36 -5.92 -0.31 7.95e-9 Response to anti-depressant treatment in major depressive disorder; CRC cis rs60871478 1.000 rs4721124 chr7:823761 T/C cg13844804 chr7:814759 HEATR2 0.65 8.49 0.42 7.41e-16 Cerebrospinal P-tau181p levels; CRC cis rs9435341 0.965 rs1730864 chr1:107607810 C/T cg14828511 chr1:107599125 PRMT6 -0.57 -7.85 -0.4 5.73e-14 Facial morphology (factor 21, depth of nasal alae); CRC cis rs2811415 0.597 rs11715883 chr3:127726465 C/T cg13719885 chr3:127795394 NA -0.38 -5.75 -0.3 2.01e-8 Lung function (FEV1/FVC); CRC cis rs6748734 0.843 rs6749674 chr2:241834501 G/C cg07537917 chr2:241836409 C2orf54 -0.22 -6.14 -0.32 2.37e-9 Urinary metabolites; CRC cis rs45509595 0.841 rs2747054 chr6:27783359 A/G cg26587870 chr6:27730563 NA -0.6 -5.98 -0.31 5.78e-9 Breast cancer; CRC cis rs782590 0.934 rs17369191 chr2:55757885 T/C cg18811423 chr2:55921094 PNPT1 0.83 15.13 0.64 1.31e-39 Metabolic syndrome; CRC cis rs7605827 0.930 rs12692272 chr2:15680801 C/T cg19274914 chr2:15703543 NA 0.38 5.8 0.3 1.59e-8 Educational attainment (years of education); CRC cis rs8180040 0.903 rs6791842 chr3:47279810 T/C cg10298567 chr3:47292165 KIF9 -0.41 -6.77 -0.35 5.84e-11 Colorectal cancer; CRC cis rs6460942 0.908 rs78682952 chr7:12284886 C/A cg06484146 chr7:12443880 VWDE -0.64 -6.53 -0.34 2.42e-10 Coronary artery disease; CRC cis rs28386778 0.897 rs2727333 chr17:61876023 G/A cg06601766 chr17:61851465 DDX42;CCDC47 0.44 5.96 0.31 6.5e-9 Prudent dietary pattern; CRC trans rs1005277 0.579 rs2472182 chr10:38388865 T/C cg27523141 chr10:43048294 ZNF37B 0.49 7.21 0.37 3.88e-12 Extrinsic epigenetic age acceleration; CRC trans rs1005277 0.579 rs1621040 chr10:38497232 T/C cg17830980 chr10:43048298 ZNF37B -0.57 -9.64 -0.47 1.51e-19 Extrinsic epigenetic age acceleration; CRC cis rs2257205 0.667 rs7217890 chr17:56731265 G/A cg25885038 chr17:56607967 SEPT4 -0.53 -5.78 -0.3 1.76e-8 Pancreatic cancer; CRC cis rs2295359 0.892 rs11209004 chr1:67613932 G/A cg17031739 chr1:67600172 NA 0.45 7.18 0.37 4.63e-12 Psoriasis; CRC cis rs847577 0.609 rs6977321 chr7:97774859 A/G cg24562669 chr7:97807699 LMTK2 0.78 17.37 0.69 2.11e-48 Breast cancer; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg15785704 chr17:30669010 C17orf75 0.43 6.4 0.33 5.38e-10 Intelligence (multi-trait analysis); CRC cis rs9928842 0.882 rs4737 chr16:75238103 A/G cg08657710 chr16:75258780 CTRB1 0.45 6.2 0.32 1.73e-9 Alcoholic chronic pancreatitis; CRC cis rs9487051 0.652 rs9372210 chr6:109601703 G/C cg12927641 chr6:109611667 NA -0.38 -6.62 -0.34 1.42e-10 Reticulocyte fraction of red cells; CRC cis rs9486719 0.895 rs12527021 chr6:97025496 C/T cg18709589 chr6:96969512 KIAA0776 -0.52 -5.85 -0.31 1.21e-8 Migraine;Coronary artery disease; CRC cis rs17401966 0.540 rs6674949 chr1:10458480 A/G cg19773385 chr1:10388646 KIF1B -0.46 -7.2 -0.37 4.14e-12 Hepatocellular carcinoma; CRC trans rs10983614 1.000 rs7867776 chr9:120072627 A/G cg04053862 chr2:179345017 MIR548N;PLEKHA3 0.49 6.61 0.34 1.58e-10 Survival in pancreatic cancer; CRC cis rs875971 1.000 rs2077593 chr7:65892530 A/G cg11764359 chr7:65958608 NA 0.61 9.75 0.47 6.69e-20 Aortic root size; CRC cis rs6088580 0.608 rs8114616 chr20:32969092 G/T cg08999081 chr20:33150536 PIGU -0.61 -11.28 -0.53 3.74e-25 Glomerular filtration rate (creatinine); CRC cis rs2380220 0.576 rs4498363 chr6:96042338 A/C cg04719120 chr6:96025338 MANEA 0.71 8.93 0.44 3.12e-17 Behavioural disinhibition (generation interaction); CRC cis rs875971 0.830 rs6967708 chr7:65657313 A/T cg11764359 chr7:65958608 NA -0.6 -9.36 -0.46 1.25e-18 Aortic root size; CRC cis rs75920871 0.588 rs10892054 chr11:116868221 C/T cg01368799 chr11:117014884 PAFAH1B2 -0.43 -6.0 -0.31 5.3300000000000004e-09 Subjective well-being; CRC cis rs2302190 0.882 rs11656888 chr17:56546725 T/A cg12560992 chr17:57184187 TRIM37 0.53 6.05 0.32 3.89e-9 Vitamin D levels; CRC cis rs427943 0.778 rs8134789 chr21:46619558 A/G cg19498844 chr21:46707878 POFUT2;LOC642852 -0.44 -6.04 -0.32 4.06e-9 Body mass index; CRC cis rs4713118 0.662 rs9380045 chr6:28025279 A/G cg25164649 chr6:28176230 NA 0.65 8.57 0.43 4.18e-16 Parkinson's disease; CRC cis rs4700695 0.719 rs36923 chr5:65464783 G/C cg21114390 chr5:65439923 SFRS12 -0.66 -8.83 -0.44 6.22e-17 Facial morphology (factor 19); CRC cis rs12580194 0.630 rs60586348 chr12:55745151 A/T cg23425280 chr12:56401806 NA 0.47 5.72 0.3 2.44e-8 Cancer; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg23090870 chr19:38755753 SPINT2 0.4 6.41 0.33 4.96e-10 Anxiety disorder; CRC cis rs1670533 0.685 rs56019586 chr4:1059842 C/G cg27284194 chr4:1044797 NA 0.48 5.99 0.31 5.5e-9 Recombination rate (females); CRC cis rs701145 0.529 rs355759 chr3:154008078 G/C cg16511985 chr3:153974050 SGEF 0.43 5.61 0.3 4.39e-8 Coronary artery disease; CRC cis rs13191362 1.000 rs34398656 chr6:162999612 G/T cg23758597 chr6:163146217 PARK2 -0.51 -5.91 -0.31 8.56e-9 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs10256972 0.758 rs7799391 chr7:1082566 C/G cg02869364 chr7:1081709 C7orf50 -0.37 -5.86 -0.31 1.13e-8 Longevity;Endometriosis; CRC cis rs597539 0.652 rs10792001 chr11:68637737 G/C cg04772025 chr11:68637568 NA 0.51 8.11 0.41 1.04e-14 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs1348850 0.567 rs880898 chr2:178532470 C/T cg22681709 chr2:178499509 PDE11A -0.44 -8.12 -0.41 9.51e-15 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs4664308 1.000 rs62175515 chr2:160909524 A/T cg03641300 chr2:160917029 PLA2R1 -0.75 -12.51 -0.57 1.18e-29 Idiopathic membranous nephropathy; CRC cis rs7727544 0.716 rs72793278 chr5:131561372 C/A cg11843238 chr5:131593191 PDLIM4 0.34 6.43 0.33 4.54e-10 Blood metabolite levels; CRC trans rs9820070 1.000 rs11721263 chr3:187688435 T/C cg09907068 chr2:197159060 HECW2 0.38 6.37 0.33 6.23e-10 Hematological and biochemical traits; CRC cis rs3733585 0.805 rs882222 chr4:9981294 G/A cg11266682 chr4:10021025 SLC2A9 0.5 10.34 0.5 6.86e-22 Cleft plate (environmental tobacco smoke interaction); CRC cis rs1707322 1.000 rs4660889 chr1:46297331 C/T cg03146154 chr1:46216737 IPP 0.51 7.13 0.37 6.41e-12 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs7043114 0.507 rs10992291 chr9:95033009 T/C cg14631576 chr9:95140430 CENPP -0.3 -5.76 -0.3 1.92e-8 Height; CRC cis rs9914578 1.000 rs8082647 chr17:2010597 C/T cg16513277 chr17:2031491 SMG6 0.5 7.42 0.38 1e-12 Body mass index; CRC cis rs11098499 0.754 rs12711071 chr4:120240934 A/G cg24375607 chr4:120327624 NA 0.48 7.56 0.38 4e-13 Corneal astigmatism; CRC cis rs17780086 0.527 rs72827711 chr17:30537920 T/A cg23018236 chr17:30244563 NA -0.58 -5.94 -0.31 7.07e-9 Height; CRC cis rs6088580 0.634 rs6059835 chr20:33020141 A/G cg08999081 chr20:33150536 PIGU 0.61 11.56 0.54 3.48e-26 Glomerular filtration rate (creatinine); CRC cis rs977987 0.654 rs8054194 chr16:75497160 G/T cg03315344 chr16:75512273 CHST6 0.61 10.09 0.49 4.83e-21 Dupuytren's disease; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg25377726 chr2:45838438 SRBD1 0.43 6.21 0.32 1.58e-9 Response to antipsychotic treatment; CRC cis rs4604732 0.588 rs12045675 chr1:247623915 C/A cg12754571 chr1:247694271 LOC148824;OR2C3 0.41 5.78 0.3 1.75e-8 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CRC cis rs4664304 0.966 rs3792198 chr2:160760338 G/A cg03641300 chr2:160917029 PLA2R1 -0.42 -5.89 -0.31 9.55e-9 Crohn's disease;Inflammatory bowel disease; CRC cis rs7224737 1.000 rs9915255 chr17:40284191 C/T cg20291162 chr17:40259547 DHX58 -0.54 -7.85 -0.4 6.06e-14 Fibrinogen levels; CRC cis rs28374715 0.662 rs521890 chr15:41473143 C/T cg18705301 chr15:41695430 NDUFAF1 -0.85 -13.08 -0.58 9.14e-32 Ulcerative colitis; CRC cis rs34172651 0.687 rs8044992 chr16:24811207 T/C cg06028605 chr16:24865363 SLC5A11 0.42 7.75 0.39 1.15e-13 Intelligence (multi-trait analysis); CRC cis rs589448 0.902 rs315134 chr12:69762713 G/A cg22834771 chr12:69754056 YEATS4 -0.56 -8.68 -0.43 1.93e-16 Cerebrospinal fluid biomarker levels; CRC cis rs734999 0.505 rs4278312 chr1:2539555 A/G cg18854424 chr1:2615690 NA 0.5 10.11 0.49 4.27e-21 Ulcerative colitis; CRC cis rs7618915 0.570 rs11130319 chr3:52755592 A/T cg15147215 chr3:52552868 STAB1 -0.61 -9.96 -0.48 1.38e-20 Bipolar disorder; CRC cis rs11098499 0.954 rs7687843 chr4:120421211 C/T cg09307838 chr4:120376055 NA 0.72 11.05 0.52 2.45e-24 Corneal astigmatism; CRC cis rs514406 0.505 rs405208 chr1:53176674 C/T cg24675658 chr1:53192096 ZYG11B -0.67 -10.11 -0.49 4.18e-21 Monocyte count; CRC cis rs12580194 0.593 rs59136392 chr12:55748204 C/T cg23425280 chr12:56401806 NA 0.44 5.61 0.3 4.19e-8 Cancer; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg12876261 chr7:56119223 PSPH;CCT6A -0.4 -6.01 -0.31 4.97e-9 Myopia (pathological); CRC cis rs1215050 0.791 rs260902 chr4:98764694 G/A cg05340658 chr4:99064831 C4orf37 0.47 6.88 0.35 3.09e-11 Waist-to-hip ratio adjusted for body mass index; CRC cis rs10504229 0.953 rs59265461 chr8:58189701 A/T cg24829409 chr8:58192753 C8orf71 -0.68 -11.34 -0.53 2.27e-25 Developmental language disorder (linguistic errors); CRC cis rs6952808 0.582 rs871925 chr7:2047875 G/A cg02951883 chr7:2050386 MAD1L1 0.63 10.43 0.5 3.47e-22 Bipolar disorder and schizophrenia; CRC cis rs2991971 0.967 rs11211130 chr1:45986852 G/C cg15605315 chr1:45957053 TESK2 0.43 6.85 0.35 3.55e-11 High light scatter reticulocyte count; CRC cis rs8077889 0.763 rs4792913 chr17:41854497 T/C cg25876840 chr17:41920477 NA 0.37 5.79 0.3 1.63e-8 Triglycerides; CRC cis rs4728302 0.869 rs958404 chr7:133597186 G/T cg10665199 chr7:133106180 EXOC4 -0.38 -5.76 -0.3 1.9e-8 Intelligence;Intelligence (multi-trait analysis); CRC cis rs7264396 0.887 rs6060438 chr20:34077403 T/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.39 -6.56 -0.34 2.11e-10 Total cholesterol levels; CRC cis rs11792861 0.781 rs874864 chr9:111728718 C/T cg05043794 chr9:111880884 C9orf5 -0.32 -5.97 -0.31 6.04e-9 Menarche (age at onset); CRC cis rs6504622 0.537 rs189899 chr17:45000529 G/C cg16759221 chr17:45003025 GOSR2 -0.68 -11.04 -0.52 2.62e-24 Orofacial clefts; CRC cis rs1670533 1.000 rs6852155 chr4:1067638 T/G cg27284194 chr4:1044797 NA 0.49 6.23 0.32 1.42e-9 Recombination rate (females); CRC cis rs7666738 0.830 rs28802909 chr4:99039410 G/A cg05340658 chr4:99064831 C4orf37 0.6 9.45 0.46 6.36e-19 Colonoscopy-negative controls vs population controls; CRC cis rs1559088 1.000 rs1559088 chr19:33551061 C/T cg27124370 chr19:33622961 WDR88 0.4 5.62 0.3 4.1e-8 Bone ultrasound measurement (broadband ultrasound attenuation); CRC cis rs853679 0.607 rs13190888 chr6:28285985 G/A cg26958806 chr6:27640298 NA 0.93 6.56 0.34 2.11e-10 Depression; CRC cis rs704795 0.902 rs11887784 chr2:27679919 A/G cg27432699 chr2:27873401 GPN1 -0.62 -9.48 -0.46 5.21e-19 Menopause (age at onset); CRC cis rs9326248 0.954 rs10790177 chr11:117048417 A/G cg10130564 chr11:117069849 TAGLN 0.37 7.03 0.36 1.21e-11 Blood protein levels; CRC cis rs1862618 0.671 rs28397234 chr5:56248428 T/G cg20203395 chr5:56204925 C5orf35 0.54 7.36 0.38 1.52e-12 Initial pursuit acceleration; CRC cis rs4332037 0.722 rs55934553 chr7:1914059 T/C cg24505167 chr7:1915268 MAD1L1 -0.47 -7.2 -0.37 4.23e-12 Bipolar disorder; CRC cis rs243505 0.767 rs243518 chr7:148425028 A/G cg09806900 chr7:148480153 CUL1 -0.46 -5.89 -0.31 9.61e-9 Inflammatory bowel disease;Crohn's disease; CRC cis rs9814567 0.929 rs9855013 chr3:134240414 C/T cg06541857 chr3:134203789 ANAPC13;CEP63 -0.4 -6.12 -0.32 2.65e-9 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs76419734 0.510 rs3943980 chr4:106676766 G/A cg24545054 chr4:106630052 GSTCD;INTS12 -0.55 -6.3 -0.33 9.4e-10 Post bronchodilator FEV1; CRC cis rs12142240 0.698 rs41294478 chr1:46818442 G/A cg14993813 chr1:46806288 NSUN4 -0.48 -6.15 -0.32 2.24e-9 Menopause (age at onset); CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg11226328 chr1:29213367 EPB41 -0.47 -6.13 -0.32 2.48e-9 Diisocyanate-induced asthma; CRC cis rs7769051 0.614 rs6912936 chr6:133102664 A/G cg07930552 chr6:133119739 C6orf192 0.59 6.96 0.36 1.81e-11 Type 2 diabetes nephropathy; CRC cis rs780096 0.525 rs13388159 chr2:27648284 A/T cg02592271 chr2:27665507 KRTCAP3 -0.27 -6.04 -0.32 4.15e-9 Total body bone mineral density; CRC cis rs9491140 0.539 rs980657 chr6:124690330 C/T cg22366943 chr6:124882293 NKAIN2 0.53 8.05 0.41 1.56e-14 Neuroticism; CRC cis rs9326248 1.000 rs585849 chr11:117069061 A/G cg10130564 chr11:117069849 TAGLN 0.38 7.03 0.36 1.22e-11 Blood protein levels; CRC cis rs1799949 1.000 rs16941 chr17:41244435 T/C cg05368731 chr17:41323189 NBR1 0.67 9.77 0.47 5.72e-20 Menopause (age at onset); CRC cis rs9660180 0.875 rs4648727 chr1:1776269 C/A cg23982607 chr1:1823379 GNB1 0.68 11.08 0.52 1.92e-24 Body mass index; CRC cis rs672059 0.967 rs657901 chr1:183163411 T/G ch.1.3577855R chr1:183094577 LAMC1 0.48 6.95 0.36 1.95e-11 Hypertriglyceridemia; CRC cis rs780096 0.506 rs8395 chr2:27715207 T/A cg27432699 chr2:27873401 GPN1 -0.57 -8.78 -0.44 8.88e-17 Total body bone mineral density; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg12500284 chr19:16683309 SLC35E1 0.47 6.69 0.35 9.68e-11 Anxiety disorder; CRC cis rs2440129 0.611 rs1126667 chr17:6902760 C/T cg03407747 chr17:6899364 ALOX12 -0.6 -10.96 -0.52 4.77e-24 Tonsillectomy; CRC cis rs3820068 0.655 rs72645823 chr1:15887442 C/T cg27534772 chr1:16042836 PLEKHM2 0.45 7.5 0.38 6.07e-13 Systolic blood pressure; CRC cis rs56146971 0.714 rs79810056 chr14:91852929 A/G cg16433844 chr14:91963127 SMEK1 -0.52 -6.11 -0.32 2.75e-9 Alzheimer disease and age of onset; CRC cis rs10911232 0.507 rs4651137 chr1:182994300 T/C ch.1.3577855R chr1:183094577 LAMC1 0.87 15.17 0.64 8.94e-40 Hypertriglyceridemia; CRC cis rs9549367 0.773 rs9549717 chr13:113908826 A/G cg00898013 chr13:113819073 PROZ -0.45 -6.41 -0.33 4.96e-10 Platelet distribution width; CRC trans rs3851050 1.000 rs3851050 chr10:81882370 A/G cg16857335 chr19:47633940 SAE1 0.42 6.03 0.32 4.37e-9 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs10992471 0.603 rs7868013 chr9:95240173 G/A cg14631576 chr9:95140430 CENPP -0.41 -7.34 -0.37 1.73e-12 Visceral adipose tissue/subcutaneous adipose tissue ratio; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg20255042 chr10:75757586 VCL 0.38 6.0 0.31 5.17e-9 Liver disease severity in Alagille syndrome; CRC cis rs10504229 0.906 rs114810777 chr8:58185298 A/G cg02725872 chr8:58115012 NA -0.38 -6.45 -0.34 3.91e-10 Developmental language disorder (linguistic errors); CRC cis rs11148252 0.634 rs1571189 chr13:52731004 A/T cg12458913 chr13:53173898 NA 0.42 6.15 0.32 2.26e-9 Lewy body disease; CRC cis rs28386778 0.897 rs2727290 chr17:61894728 G/T cg22520471 chr17:61851767 DDX42;CCDC47 0.75 11.75 0.54 7.35e-27 Prudent dietary pattern; CRC cis rs11958404 0.932 rs12517979 chr5:157428918 T/C cg05962755 chr5:157440814 NA 0.88 11.52 0.54 4.97e-26 IgG glycosylation; CRC cis rs67340775 0.541 rs200973 chr6:27858421 A/G cg25164649 chr6:28176230 NA 0.57 5.9 0.31 9.27e-9 Lung cancer in ever smokers; CRC cis rs28655083 0.509 rs664408 chr16:77104820 A/G cg01753188 chr16:77233325 SYCE1L;MON1B 0.46 6.59 0.34 1.76e-10 Lobe attachment (rater-scored or self-reported); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg03195600 chr16:11350371 SOCS1 0.45 7.23 0.37 3.32e-12 Liver disease severity in Alagille syndrome; CRC cis rs7677751 0.767 rs6831380 chr4:55076345 G/A cg13615338 chr4:55094005 PDGFRA 0.4 5.82 0.31 1.4e-8 Corneal astigmatism; CRC cis rs9914988 0.943 rs7215310 chr17:27088626 G/T cg16670446 chr17:27188758 MIR451;MIR144 0.53 8.68 0.43 1.85e-16 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs6502050 0.835 rs35070385 chr17:80128447 G/A cg22110888 chr17:80059540 CCDC57 0.4 6.43 0.33 4.37e-10 Life satisfaction; CRC cis rs1799949 0.628 rs4474733 chr17:41433660 G/T cg19454999 chr17:41278357 BRCA1;NBR2 0.45 6.24 0.33 1.34e-9 Menopause (age at onset); CRC cis rs896854 0.967 rs10808671 chr8:95967372 A/G cg16049864 chr8:95962084 TP53INP1 -0.68 -12.38 -0.56 3.61e-29 Type 2 diabetes; CRC cis rs908922 0.676 rs6674451 chr1:152531054 C/T cg23254163 chr1:152506842 NA 0.45 9.15 0.45 6.31e-18 Hair morphology; CRC cis rs9399135 0.838 rs4896126 chr6:135342786 C/A cg24558204 chr6:135376177 HBS1L 0.52 8.21 0.41 5.05e-15 Red blood cell count; CRC cis rs2279817 1.000 rs1339801 chr1:18020298 A/G cg21791023 chr1:18019539 ARHGEF10L 0.49 6.41 0.33 5.1e-10 Neuroticism; CRC cis rs4986172 0.726 rs12946454 chr17:43208121 A/T cg10701640 chr17:43249399 NA 0.46 9.63 0.47 1.74e-19 Height; CRC cis rs6502050 0.835 rs62078304 chr17:80085224 G/A cg13198984 chr17:80129470 CCDC57 -0.46 -7.97 -0.4 2.65e-14 Life satisfaction; CRC cis rs8031584 0.697 rs8036176 chr15:31175269 A/G cg14829155 chr15:31115871 NA -0.57 -8.65 -0.43 2.39e-16 Huntington's disease progression; CRC cis rs6460942 0.749 rs79221452 chr7:12202897 T/C cg06484146 chr7:12443880 VWDE -0.62 -5.86 -0.31 1.12e-8 Coronary artery disease; CRC cis rs2762353 0.718 rs1165205 chr6:25870542 A/T cg03264133 chr6:25882463 NA 0.5 7.6 0.39 3.11e-13 Blood metabolite levels; CRC cis rs5750830 0.649 rs5757664 chr22:39821536 A/G cg25956985 chr22:39795188 MAP3K7IP1 -0.47 -6.87 -0.35 3.15e-11 Intelligence (multi-trait analysis); CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg14361641 chr2:70056642 GMCL1 0.48 6.26 0.33 1.2e-9 Thyroid stimulating hormone; CRC cis rs9487051 0.698 rs11153168 chr6:109629420 A/T cg01475377 chr6:109611718 NA -0.36 -5.94 -0.31 7.07e-9 Reticulocyte fraction of red cells; CRC cis rs10751667 1.000 rs10794349 chr11:945678 T/C ch.11.42038R chr11:967971 AP2A2 0.7 11.72 0.54 9.56e-27 Alzheimer's disease (late onset); CRC cis rs8014671 0.553 rs34273029 chr14:70892225 C/T cg25576086 chr14:70833871 SYNJ2BP -0.36 -6.06 -0.32 3.63e-9 Prostate cancer; CRC cis rs2839186 0.770 rs2839984 chr21:47671690 A/G cg13126279 chr21:47581558 C21orf56 -0.48 -7.64 -0.39 2.37e-13 Testicular germ cell tumor; CRC cis rs1448094 0.511 rs10506923 chr12:86152595 C/T cg19622623 chr12:86230825 RASSF9 0.38 5.81 0.31 1.46e-8 Major depressive disorder; CRC cis rs7917772 0.536 rs12357172 chr10:104388549 C/T cg22532475 chr10:104410764 TRIM8 -0.42 -6.91 -0.36 2.55e-11 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC cis rs34172651 0.517 rs200528 chr16:24759131 A/G cg04756594 chr16:24857601 SLC5A11 -0.33 -6.87 -0.35 3.29e-11 Intelligence (multi-trait analysis); CRC cis rs908922 0.676 rs11205031 chr1:152527662 C/T cg23254163 chr1:152506842 NA 0.49 9.71 0.47 8.9e-20 Hair morphology; CRC cis rs875971 1.000 rs778706 chr7:65860424 A/G cg00343986 chr7:65444356 GUSB 0.43 6.3 0.33 9.66e-10 Aortic root size; CRC cis rs7216064 0.765 rs6504550 chr17:65894542 A/G cg12091567 chr17:66097778 LOC651250 -0.67 -8.79 -0.44 8.55e-17 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CRC cis rs929354 0.772 rs2023977 chr7:156996022 C/G cg16102536 chr7:156981717 UBE3C 0.4 6.77 0.35 5.77e-11 Body mass index; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg02624704 chr1:173446429 PRDX6 0.37 6.65 0.34 1.23e-10 Liver disease severity in Alagille syndrome; CRC cis rs2032447 0.839 rs9356995 chr6:25996673 G/A cg03517284 chr6:25882590 NA -0.48 -6.58 -0.34 1.89e-10 Intelligence (multi-trait analysis); CRC cis rs5769765 0.908 rs9616217 chr22:50318946 C/T cg02269571 chr22:50332266 NA -0.61 -7.77 -0.39 1.03e-13 Schizophrenia; CRC cis rs7605827 0.930 rs4668910 chr2:15608013 C/A cg19274914 chr2:15703543 NA 0.39 5.95 0.31 6.89e-9 Educational attainment (years of education); CRC cis rs3733585 0.699 rs6449171 chr4:9965998 C/T cg00071950 chr4:10020882 SLC2A9 0.53 9.33 0.46 1.56e-18 Cleft plate (environmental tobacco smoke interaction); CRC cis rs6860806 0.507 rs272854 chr5:131688017 C/T cg18758796 chr5:131593413 PDLIM4 0.4 6.48 0.34 3.43e-10 Breast cancer; CRC cis rs62408225 1.000 rs2089126 chr6:90970212 A/G cg06866423 chr6:90926672 BACH2 0.48 7.94 0.4 3.23e-14 Eosinophil counts;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC trans rs877282 0.755 rs2486579 chr10:785647 G/A cg22713356 chr15:30763199 NA 1.0 12.25 0.56 1.08e-28 Uric acid levels; CRC cis rs2204008 0.577 rs11520050 chr12:38051839 G/A cg13010199 chr12:38710504 ALG10B 0.44 5.64 0.3 3.74e-8 Bladder cancer; CRC cis rs6459788 0.720 rs6965466 chr7:157250749 G/T cg01766193 chr7:157202248 DNAJB6 -0.35 -5.81 -0.31 1.48e-8 Epstein-Barr virus copy number in lymphoblastoid cell lines; CRC cis rs1005277 0.579 rs1740732 chr10:38491385 C/T cg25427524 chr10:38739819 LOC399744 -0.79 -14.51 -0.62 3.28e-37 Extrinsic epigenetic age acceleration; CRC cis rs270601 0.690 rs162907 chr5:131580152 A/G cg02033258 chr5:131593261 PDLIM4 -0.5 -9.05 -0.45 1.24e-17 Acylcarnitine levels; CRC cis rs7247513 1.000 rs2042947 chr19:12693103 A/G cg01871581 chr19:12707946 ZNF490 -0.73 -11.98 -0.55 1.13e-27 Bipolar disorder; CRC cis rs2979489 0.891 rs2915625 chr8:30382651 G/A cg26383811 chr8:30366931 RBPMS -0.7 -10.07 -0.49 5.93e-21 Mean corpuscular hemoglobin;Plateletcrit;Neutrophil count;Granulocyte count;Sum basophil neutrophil counts;Mean corpuscular volume;Myeloid white cell count;Sum neutrophil eosinophil counts; CRC cis rs7247513 0.964 rs8105902 chr19:12718351 G/A cg01871581 chr19:12707946 ZNF490 -0.81 -13.13 -0.59 5.7e-32 Bipolar disorder; CRC cis rs8105895 0.935 rs10406551 chr19:22244520 T/A cg02657401 chr19:22469223 NA -0.34 -5.65 -0.3 3.56e-8 Body mass index (change over time); CRC cis rs4731207 0.562 rs6466991 chr7:124691966 T/G cg23710748 chr7:124431027 NA -0.39 -6.14 -0.32 2.35e-9 Cutaneous malignant melanoma; CRC cis rs13082711 0.911 rs13077400 chr3:27473066 A/G cg02860705 chr3:27208620 NA 0.59 8.41 0.42 1.28e-15 Systolic blood pressure;Diastolic blood pressure;Blood pressure; CRC cis rs189798 0.807 rs12785 chr8:8994936 A/T cg20515095 chr8:8998461 PPP1R3B -0.46 -5.79 -0.3 1.64e-8 Myopia (pathological); CRC cis rs4665809 0.590 rs13006973 chr2:26454707 C/T cg04944784 chr2:26401820 FAM59B 0.83 10.74 0.51 2.96e-23 Gut microbiome composition (summer); CRC cis rs6545883 0.965 rs1562308 chr2:61768421 A/C cg15711740 chr2:61764176 XPO1 -0.52 -7.2 -0.37 4.23e-12 Tuberculosis; CRC cis rs7586879 1.000 rs1865687 chr2:25112885 G/A cg22495460 chr2:25135724 ADCY3 -0.73 -11.97 -0.55 1.19e-27 Body mass index; CRC trans rs10504229 1.000 rs66495524 chr8:58187365 C/T cg04077850 chr5:125800366 GRAMD3 0.37 6.27 0.33 1.15e-9 Developmental language disorder (linguistic errors); CRC cis rs910316 1.000 rs3742780 chr14:75505008 G/C cg03030879 chr14:75389066 RPS6KL1 -0.45 -6.98 -0.36 1.59e-11 Height; CRC cis rs11098499 0.909 rs17046118 chr4:120387496 T/G cg09307838 chr4:120376055 NA 0.71 10.92 0.52 6.75e-24 Corneal astigmatism; CRC cis rs12936587 0.595 rs9911672 chr17:17528670 C/T cg09796270 chr17:17721594 SREBF1 0.39 5.95 0.31 6.86e-9 Hip circumference;Coronary artery disease or large artery stroke;Coronary heart disease;Coronary artery disease; CRC trans rs1814175 0.791 rs10769625 chr11:49869887 G/A cg11707556 chr5:10655725 ANKRD33B -0.44 -8.39 -0.42 1.42e-15 Height; CRC cis rs11098499 0.820 rs2389885 chr4:120533931 C/T cg09307838 chr4:120376055 NA 0.7 9.94 0.48 1.62e-20 Corneal astigmatism; CRC cis rs992157 0.835 rs13031757 chr2:219151926 T/C cg04731861 chr2:219085781 ARPC2 0.34 6.94 0.36 2.13e-11 Colorectal cancer; CRC cis rs28386778 0.734 rs12946669 chr17:62006007 A/G cg23090583 chr17:61904693 PSMC5;FTSJ3 0.68 10.56 0.5 1.21e-22 Prudent dietary pattern; CRC cis rs1267303 0.675 rs1267312 chr1:46986748 C/G cg25110126 chr1:46999211 NA -0.55 -8.31 -0.42 2.52e-15 Monobrow; CRC cis rs1007738 0.597 rs10838635 chr11:46945227 G/A cg19486271 chr11:47235900 DDB2 -0.45 -6.79 -0.35 5.24e-11 Bone mineral density (hip); CRC cis rs7493 0.901 rs17883318 chr7:94958312 G/A cg19678392 chr7:94953810 PON1 -0.51 -6.97 -0.36 1.74e-11 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs12620999 0.941 rs2078469 chr2:237983273 C/G cg23555395 chr2:238036564 NA 0.59 9.62 0.47 1.77e-19 Systemic lupus erythematosus; CRC cis rs728616 0.681 rs55838345 chr10:82085120 G/C cg05935833 chr10:81318306 SFTPA2 -0.57 -7.0 -0.36 1.48e-11 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs9486715 0.838 rs4839840 chr6:96941149 T/C cg06623918 chr6:96969491 KIAA0776 1.02 20.32 0.75 4.57e-60 Headache; CRC cis rs262150 0.819 rs6956589 chr7:158769301 C/T cg10570241 chr7:158785291 NA 0.52 9.25 0.45 2.82e-18 Facial morphology (factor 20); CRC cis rs12318506 0.826 rs11180453 chr12:75694006 T/C cg04728562 chr12:75699417 CAPS2 -0.85 -6.67 -0.35 1.1e-10 Coronary artery calcification; CRC cis rs780096 0.527 rs59644396 chr2:27646083 A/G cg22903471 chr2:27725779 GCKR -0.37 -6.04 -0.32 4.24e-9 Total body bone mineral density; CRC cis rs17401966 0.867 rs61775872 chr1:10279308 T/C cg19773385 chr1:10388646 KIF1B -0.63 -9.66 -0.47 1.37e-19 Hepatocellular carcinoma; CRC cis rs7044106 0.708 rs2416760 chr9:123374639 T/C cg09586646 chr9:123605570 PSMD5;LOC253039 0.55 8.08 0.41 1.24e-14 Hip circumference adjusted for BMI; CRC cis rs875971 0.862 rs11773628 chr7:65982631 G/T cg18876405 chr7:65276391 NA -0.5 -8.25 -0.41 3.86e-15 Aortic root size; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg09192333 chr22:38142150 TRIOBP 0.38 6.62 0.34 1.48e-10 Liver disease severity in Alagille syndrome; CRC cis rs904251 0.864 rs2797801 chr6:37487161 A/G cg25019722 chr6:37503610 NA -0.5 -9.29 -0.46 2.17e-18 Cognitive performance; CRC trans rs587242 1.000 rs509588 chr1:96891552 G/C cg10631902 chr5:14652156 NA 0.45 6.9 0.36 2.7e-11 Body mass index (joint analysis main effects and physical activity interaction);Body mass index in physically inactive individuals;Body mass index; CRC cis rs7829975 0.840 rs572366 chr8:8578794 A/T cg08975724 chr8:8085496 FLJ10661 0.43 6.55 0.34 2.21e-10 Mood instability; CRC cis rs6840360 0.667 rs2709832 chr4:152379394 C/G cg09659197 chr4:152720779 NA 0.33 6.46 0.34 3.69e-10 Intelligence (multi-trait analysis); CRC cis rs4713118 0.662 rs156744 chr6:27967274 G/A cg06470822 chr6:28175283 NA 0.89 13.5 0.6 2.35e-33 Parkinson's disease; CRC cis rs12956009 0.583 rs11663646 chr18:44862895 A/G cg19077165 chr18:44547161 KATNAL2 0.38 5.73 0.3 2.27e-8 Educational attainment (years of education); CRC cis rs9486715 0.867 rs1127175 chr6:96999725 C/T cg18709589 chr6:96969512 KIAA0776 -0.5 -7.45 -0.38 8.54e-13 Headache; CRC cis rs6545883 0.524 rs12992614 chr2:61593076 C/T cg10580144 chr2:61372316 C2orf74 -0.35 -7.9 -0.4 4.33e-14 Tuberculosis; CRC cis rs9787249 0.957 rs12086750 chr1:40210468 G/C cg19912559 chr1:40204330 PPIE 0.52 7.64 0.39 2.47e-13 Blood protein levels; CRC cis rs2014572 0.967 rs8106734 chr19:57763546 C/T cg12963866 chr19:57752005 ZNF805 -0.39 -5.75 -0.3 2.02e-8 Hyperactive-impulsive symptoms; CRC cis rs2072499 1.000 rs2072499 chr1:156169610 A/G cg06970220 chr1:156163860 SLC25A44 0.5 7.2 0.37 4.15e-12 Testicular germ cell tumor; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg17113216 chr4:83821792 THAP9 0.37 5.99 0.31 5.58e-9 Liver disease severity in Alagille syndrome; CRC cis rs4713118 0.868 rs7756968 chr6:27734954 C/G cg03623178 chr6:28175578 NA 0.74 8.1 0.41 1.08e-14 Parkinson's disease; CRC cis rs13108904 0.517 rs13128825 chr4:1334007 G/A cg02018176 chr4:1364513 KIAA1530 0.39 5.72 0.3 2.38e-8 Obesity-related traits; CRC cis rs1348850 0.789 rs2197611 chr2:178369036 G/C cg02961200 chr2:178257176 LOC100130691;AGPS 0.59 8.54 0.43 5.2e-16 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs2836974 0.584 rs6517535 chr21:40653352 G/C cg17971929 chr21:40555470 PSMG1 -0.72 -11.15 -0.52 1.05e-24 Cognitive function; CRC cis rs6089584 0.888 rs6061982 chr20:60620673 C/T cg13770153 chr20:60521292 NA -0.58 -8.71 -0.43 1.55e-16 Body mass index; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg27546264 chr17:76183398 AFMID;TK1 0.48 6.61 0.34 1.52e-10 Anxiety disorder; CRC cis rs883565 0.740 rs2037655 chr3:39072754 T/C cg01426195 chr3:39028469 NA -0.53 -8.53 -0.43 5.4e-16 Handedness; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg17151058 chr1:172502035 C1orf9 0.39 6.0 0.31 5.16e-9 Intelligence (multi-trait analysis); CRC cis rs17376456 0.825 rs10061377 chr5:93174513 T/C cg25358565 chr5:93447407 FAM172A 1.0 9.9 0.48 2.12e-20 Diabetic retinopathy; CRC cis rs2227564 0.729 rs2633304 chr10:75650650 T/C cg00564723 chr10:75632066 CAMK2G -0.33 -7.63 -0.39 2.58e-13 Crohn's disease;Inflammatory bowel disease; CRC cis rs919433 0.963 rs1896857 chr2:198164530 A/G cg10820045 chr2:198174542 NA -0.53 -9.64 -0.47 1.51e-19 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC trans rs9409565 0.826 rs4744345 chr9:97207669 G/A cg05679027 chr9:99775184 HIATL2 -0.41 -6.15 -0.32 2.24e-9 Colorectal cancer (alcohol consumption interaction); CRC cis rs853679 0.550 rs1225598 chr6:28160799 T/G cg06470822 chr6:28175283 NA 1.01 15.38 0.65 1.29e-40 Depression; CRC cis rs9368481 0.761 rs9357030 chr6:26985026 G/T cg10547057 chr6:26987810 LOC100270746;C6orf41 -0.43 -6.22 -0.32 1.51e-9 Autism spectrum disorder or schizophrenia; CRC cis rs6121246 0.909 rs6060793 chr20:30288830 T/G cg07809909 chr20:30433512 FOXS1 0.35 5.64 0.3 3.75e-8 Mean corpuscular hemoglobin; CRC cis rs939658 0.567 rs11631829 chr15:79446529 C/T cg17916960 chr15:79447300 NA -0.38 -5.93 -0.31 7.85e-9 Refractive error; CRC cis rs9287719 0.934 rs6432115 chr2:10748343 G/T cg00105475 chr2:10696890 NA 0.45 7.17 0.37 4.87e-12 Prostate cancer; CRC cis rs7726839 0.561 rs72703050 chr5:582917 A/C cg14541582 chr5:601475 NA -0.32 -6.64 -0.34 1.29e-10 Obesity-related traits; CRC cis rs1005277 0.579 rs2505241 chr10:38442421 T/C cg17219203 chr10:38645113 HSD17B7P2 -0.4 -5.68 -0.3 3.03e-8 Extrinsic epigenetic age acceleration; CRC cis rs644799 1.000 rs500054 chr11:95593806 G/A cg25478527 chr11:95522999 CEP57;FAM76B 0.52 7.6 0.39 3.1e-13 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs1865760 0.892 rs2328903 chr6:25935765 T/C cg16482183 chr6:26056742 HIST1H1C 0.54 7.44 0.38 9.04e-13 Height; CRC cis rs2952156 0.920 rs2517957 chr17:37838716 G/A cg07936489 chr17:37558343 FBXL20 -0.46 -6.54 -0.34 2.36e-10 Asthma; CRC cis rs2243480 1.000 rs316332 chr7:65604299 A/G cg12463550 chr7:65579703 CRCP 0.7 6.5 0.34 3.03e-10 Diabetic kidney disease; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg00840257 chr16:8963031 CARHSP1 0.38 6.2 0.32 1.67e-9 Liver disease severity in Alagille syndrome; CRC trans rs561341 1.000 rs2470243 chr17:30290955 C/T cg20587970 chr11:113659929 NA -1.42 -20.2 -0.74 1.43e-59 Hip circumference adjusted for BMI; CRC cis rs6752107 1.000 rs35300242 chr2:234168790 G/A cg07618928 chr2:234183455 ATG16L1;SCARNA5 0.64 10.9 0.52 8.04e-24 Crohn's disease;Inflammatory bowel disease; CRC cis rs16867321 0.950 rs2887180 chr2:181449305 C/A cg23363182 chr2:181467187 NA -0.56 -7.17 -0.37 5.02e-12 Obesity; CRC cis rs4144743 0.528 rs16941802 chr17:45355353 C/G cg18085866 chr17:45331354 ITGB3 0.63 6.62 0.34 1.48e-10 Body mass index; CRC cis rs727505 0.564 rs67745021 chr7:124868018 T/C cg23710748 chr7:124431027 NA -0.62 -10.29 -0.49 1.04e-21 Lewy body disease; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg08265551 chr1:151032119 CDC42SE1;MLLT11 0.37 6.45 0.34 4.04e-10 Liver disease severity in Alagille syndrome; CRC cis rs3736485 0.609 rs1456299 chr15:51982065 T/A cg08986416 chr15:51914746 DMXL2 -0.4 -5.63 -0.3 3.89e-8 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs7737355 0.947 rs11242078 chr5:130792035 A/C cg06307176 chr5:131281290 NA -0.43 -6.43 -0.33 4.55e-10 Life satisfaction; CRC cis rs2762353 0.779 rs9393672 chr6:25842605 T/G cg03264133 chr6:25882463 NA -0.44 -6.68 -0.35 1.05e-10 Blood metabolite levels; CRC cis rs9914988 0.943 rs3181215 chr17:27077331 C/T cg12682573 chr17:27188876 MIR451;MIR144 -0.58 -8.49 -0.42 7.41e-16 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs10540 0.730 rs12789735 chr11:518509 G/A cg03934478 chr11:495069 RNH1 0.71 7.89 0.4 4.58e-14 Body mass index; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg15034861 chr7:77428679 PHTF2;TMEM60 0.42 6.22 0.32 1.48e-9 Intelligence (multi-trait analysis); CRC cis rs12760731 0.565 rs12030488 chr1:178094751 A/C cg00404053 chr1:178313656 RASAL2 -1.0 -10.69 -0.51 4.48e-23 Obesity-related traits; CRC cis rs7493 0.950 rs17880101 chr7:95031457 A/T cg07404485 chr7:94953653 PON1 -0.47 -6.15 -0.32 2.29e-9 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs34172651 0.517 rs12920774 chr16:24830750 T/C cg06505273 chr16:24850292 NA 0.52 6.46 0.34 3.68e-10 Intelligence (multi-trait analysis); CRC cis rs6502050 0.769 rs8068708 chr17:80120424 T/C cg11859384 chr17:80120422 CCDC57 -0.36 -5.72 -0.3 2.43e-8 Life satisfaction; CRC cis rs2462686 1.000 rs2462327 chr7:45993039 C/A cg15898840 chr7:45960834 IGFBP3 -0.39 -5.81 -0.3 1.49e-8 Major depressive disorder; CRC cis rs6968419 0.755 rs2896180 chr7:115897871 A/G cg02561103 chr7:115862891 TES -0.43 -6.46 -0.34 3.83e-10 Intraocular pressure; CRC cis rs896854 0.596 rs7823059 chr8:95974961 T/C cg13393036 chr8:95962371 TP53INP1 -0.54 -9.29 -0.46 2.16e-18 Type 2 diabetes; CRC cis rs7259376 0.936 rs4932759 chr19:22540105 C/T cg02657401 chr19:22469223 NA -0.34 -7.61 -0.39 2.85e-13 Menopause (age at onset); CRC cis rs7103648 0.742 rs34937994 chr11:47389638 C/T cg20307385 chr11:47447363 PSMC3 0.92 14.8 0.63 2.39e-38 Diastolic blood pressure;Systolic blood pressure; CRC cis rs7524258 0.868 rs6577428 chr1:7314655 C/T cg07173049 chr1:7289937 CAMTA1 -0.61 -10.04 -0.48 7.08e-21 Tourette's syndrome or obsessive-compulsive disorder; CRC cis rs10504229 0.636 rs117439064 chr8:58055279 A/G cg20607798 chr8:58055168 NA 0.52 5.94 0.31 7.24e-9 Developmental language disorder (linguistic errors); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg10950113 chr16:69166907 CHTF8;CIRH1A 0.4 6.0 0.31 5.09e-9 Intelligence (multi-trait analysis); CRC cis rs2239547 0.522 rs2581805 chr3:52979050 T/C cg10802521 chr3:52805072 NEK4 0.44 6.14 0.32 2.34e-9 Schizophrenia; CRC cis rs861020 0.771 rs1962735 chr1:210012102 A/G cg09163369 chr1:210001066 C1orf107 0.46 6.35 0.33 7.09e-10 Orofacial clefts; CRC cis rs9309473 0.950 rs6735946 chr2:73790058 A/G cg20560298 chr2:73613845 ALMS1 -0.48 -5.96 -0.31 6.5e-9 Metabolite levels; CRC cis rs6952808 0.575 rs2056479 chr7:1954273 G/A cg21782813 chr7:2030301 MAD1L1 0.39 7.1 0.36 7.84e-12 Bipolar disorder and schizophrenia; CRC cis rs1401999 0.510 rs12634398 chr3:183708405 A/G cg01324343 chr3:183735012 ABCC5 0.59 9.5 0.46 4.45e-19 Anterior chamber depth; CRC cis rs2692947 0.759 rs1917890 chr2:96672001 C/T cg23100626 chr2:96804247 ASTL 0.24 6.64 0.34 1.3100000000000001e-10 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; CRC cis rs9640161 0.711 rs55881542 chr7:150025734 G/A cg12556325 chr7:150026731 C7orf29;LRRC61 -0.49 -7.18 -0.37 4.77e-12 Blood protein levels;Circulating chemerin levels; CRC cis rs9928842 0.722 rs1035540 chr16:75278795 A/G cg08657710 chr16:75258780 CTRB1 -0.57 -6.79 -0.35 5.26e-11 Alcoholic chronic pancreatitis; CRC cis rs796364 1.000 rs281760 chr2:200787804 A/G cg25936922 chr2:200820526 C2orf60;C2orf47 0.7 7.65 0.39 2.21e-13 Schizophrenia; CRC trans rs1728785 1.000 rs1170442 chr16:68574064 G/T cg04657470 chr2:198365150 HSPE1;HSPD1 0.58 7.0 0.36 1.46e-11 Ulcerative colitis; CRC cis rs1348850 0.632 rs11678875 chr2:178509068 A/G cg22681709 chr2:178499509 PDE11A -0.49 -9.04 -0.45 1.38e-17 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs1018836 0.886 rs10283086 chr8:91616651 G/A cg16814680 chr8:91681699 NA -0.77 -12.3 -0.56 7.23e-29 Ejection fraction in Tripanosoma cruzi seropositivity; CRC cis rs3820068 0.603 rs1122387 chr1:15947282 T/C cg24675056 chr1:15929824 NA 0.51 7.04 0.36 1.14e-11 Systolic blood pressure; CRC cis rs11166629 1.000 rs4909331 chr8:135644540 T/C cg27224718 chr8:135614730 ZFAT 0.52 7.68 0.39 1.82e-13 Smoking quantity; CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg01027365 chr2:191184571 HIBCH 0.4 6.19 0.32 1.82e-9 Obesity-related traits; CRC cis rs11212617 0.967 rs228608 chr11:108088900 C/T cg12106634 chr11:108092400 ATM;NPAT 0.42 6.27 0.33 1.14e-9 Response to metformin in type 2 diabetes (glycemic); CRC cis rs10911232 0.507 rs10752891 chr1:183023283 G/A ch.1.3577855R chr1:183094577 LAMC1 0.83 14.62 0.63 1.22e-37 Hypertriglyceridemia; CRC trans rs561341 0.941 rs4525554 chr17:30312819 T/C cg20587970 chr11:113659929 NA -1.43 -20.51 -0.75 8.67e-61 Hip circumference adjusted for BMI; CRC cis rs2180341 0.782 rs6912196 chr6:127722732 C/G cg27446573 chr6:127587934 RNF146 0.72 10.03 0.48 7.82e-21 Breast cancer; CRC cis rs2836974 0.899 rs35774464 chr21:40580169 G/A cg06238570 chr21:40685208 BRWD1 0.75 10.21 0.49 1.99e-21 Cognitive function; CRC cis rs6502050 0.799 rs7502533 chr17:80109778 A/G cg09264619 chr17:80180166 NA -0.34 -5.81 -0.3 1.5e-8 Life satisfaction; CRC cis rs11212617 1.000 rs228594 chr11:108104525 A/G cg01991180 chr11:108092276 ATM;NPAT 0.42 6.17 0.32 2.01e-9 Response to metformin in type 2 diabetes (glycemic); CRC cis rs7618915 0.571 rs1961959 chr3:52585760 G/C cg05573699 chr3:52720067 GNL3;PBRM1 -0.44 -6.23 -0.32 1.43e-9 Bipolar disorder; CRC cis rs1046896 0.514 rs9894705 chr17:80823758 A/C cg08200770 chr17:80723486 TBCD 0.48 7.53 0.38 5.07e-13 Glycated hemoglobin levels; CRC cis rs1728785 1.000 rs8058145 chr16:68584090 G/A cg02972257 chr16:68554789 NA -0.58 -7.24 -0.37 3.21e-12 Ulcerative colitis; CRC cis rs11758351 1.000 rs77961951 chr6:26186075 A/G cg01420254 chr6:26195488 NA 0.89 9.03 0.45 1.45e-17 Gout;Renal underexcretion gout; CRC cis rs6942756 0.876 rs7789697 chr7:129060386 T/A cg02491457 chr7:128862824 NA -0.59 -7.99 -0.4 2.38e-14 White matter hyperintensity burden; CRC cis rs9914988 0.943 rs9908881 chr17:27100924 T/A cg16670446 chr17:27188758 MIR451;MIR144 0.55 8.52 0.43 5.75e-16 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs7666738 0.830 rs13129479 chr4:98987860 T/C cg05340658 chr4:99064831 C4orf37 0.6 9.41 0.46 8.57e-19 Colonoscopy-negative controls vs population controls; CRC cis rs13191362 1.000 rs36107456 chr6:162997399 T/G cg23758597 chr6:163146217 PARK2 -0.51 -5.91 -0.31 8.56e-9 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs7113874 0.504 rs10743081 chr11:8624100 T/G cg02811074 chr11:8615871 STK33 0.33 5.88 0.31 9.85e-9 Body mass index in physically active individuals;Body mass index (joint analysis main effects and physical activity interaction); CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg18788524 chr1:145096602 SEC22B -0.42 -6.37 -0.33 6.19e-10 Myopia (pathological); CRC trans rs11039798 0.777 rs2202454 chr11:49011009 T/C cg03929089 chr4:120376271 NA 0.64 5.98 0.31 5.74e-9 Axial length; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg25604994 chr2:201983264 CFLAR 0.5 6.58 0.34 1.89e-10 Thyroid stimulating hormone; CRC cis rs4713118 0.662 rs149970 chr6:27980220 C/T cg06470822 chr6:28175283 NA 0.87 12.36 0.56 4.32e-29 Parkinson's disease; CRC trans rs1728785 1.000 rs4783653 chr16:68562815 C/T cg04657470 chr2:198365150 HSPE1;HSPD1 0.54 6.43 0.33 4.46e-10 Ulcerative colitis; CRC cis rs1862618 0.853 rs252902 chr5:56116085 A/G cg12311346 chr5:56204834 C5orf35 -0.74 -9.96 -0.48 1.37e-20 Initial pursuit acceleration; CRC cis rs6912958 0.667 rs7746545 chr6:88090225 A/G cg08069147 chr6:88032118 GJB7;C6orf162 0.73 11.58 0.54 3.15e-26 Monocyte percentage of white cells; CRC cis rs9463078 0.764 rs10948187 chr6:44921320 A/G cg25276700 chr6:44698697 NA 0.27 6.69 0.35 9.45e-11 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; CRC trans rs61931739 0.500 rs11053066 chr12:34185318 G/A cg26384229 chr12:38710491 ALG10B 0.54 6.88 0.35 2.99e-11 Morning vs. evening chronotype; CRC cis rs4664293 0.625 rs6738523 chr2:160537714 G/A cg08347373 chr2:160653686 CD302 0.39 6.52 0.34 2.67e-10 Monocyte percentage of white cells; CRC cis rs12134245 0.719 rs61798831 chr1:91996588 C/T cg07090678 chr1:91966139 CDC7 0.42 6.9 0.36 2.68e-11 Breast cancer; CRC cis rs28386778 0.831 rs2584618 chr17:61923611 T/C cg06601766 chr17:61851465 DDX42;CCDC47 0.44 5.97 0.31 6.04e-9 Prudent dietary pattern; CRC cis rs7932354 0.536 rs10838620 chr11:46818098 G/A cg19486271 chr11:47235900 DDB2 -0.43 -6.51 -0.34 2.77e-10 Bone mineral density (hip);Bone mineral density; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg07574458 chr4:17513646 QDPR 0.36 6.05 0.32 3.95e-9 Liver disease severity in Alagille syndrome; CRC trans rs11148252 0.774 rs7334583 chr13:52930352 G/T cg18335740 chr13:41363409 SLC25A15 -0.57 -8.99 -0.44 1.92e-17 Lewy body disease; CRC cis rs734999 0.524 rs4648448 chr1:2695687 C/T cg20673091 chr1:2541236 MMEL1 0.38 5.92 0.31 8.16e-9 Ulcerative colitis; CRC cis rs9611565 0.765 rs132905 chr22:41799106 C/A cg03806693 chr22:41940476 POLR3H 1.0 12.51 0.57 1.19e-29 Vitiligo; CRC cis rs9393692 0.875 rs12526215 chr6:26262916 T/C cg00631329 chr6:26305371 NA -0.68 -12.87 -0.58 5.36e-31 Educational attainment; CRC trans rs11098499 0.754 rs12513083 chr4:120249612 A/T cg25214090 chr10:38739885 LOC399744 0.53 8.36 0.42 1.81e-15 Corneal astigmatism; CRC cis rs7998202 0.667 rs282575 chr13:113359524 G/C cg01692110 chr13:113365389 ATP11A -0.49 -5.95 -0.31 6.9e-9 Glycated hemoglobin levels; CRC cis rs4665809 1.000 rs10048648 chr2:26320315 T/C cg26119090 chr2:26468346 HADHA;HADHB -0.6 -7.93 -0.4 3.47e-14 Gut microbiome composition (summer); CRC cis rs9733 0.596 rs17658705 chr1:150678071 A/C cg18016565 chr1:150552671 MCL1 -0.45 -6.5 -0.34 3.01e-10 Tonsillectomy; CRC cis rs7918232 0.830 rs7911024 chr10:27433636 A/C cg14240646 chr10:27532245 ACBD5 -0.85 -9.81 -0.48 4.13e-20 Breast cancer; CRC cis rs68170813 0.559 rs6949961 chr7:106850755 G/T cg02696742 chr7:106810147 HBP1 0.58 6.45 0.33 4.06e-10 Coronary artery disease; CRC cis rs8060686 0.641 rs116821144 chr16:68081341 A/G cg08314208 chr16:67682810 RLTPR -0.63 -6.59 -0.34 1.78e-10 HDL cholesterol;Metabolic syndrome; CRC cis rs1707322 1.000 rs10890360 chr1:46338444 C/T cg06784218 chr1:46089804 CCDC17 0.51 8.95 0.44 2.75e-17 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs2836754 1.000 rs2836751 chr21:40290959 C/T cg20434300 chr21:40194735 ETS2 -0.34 -5.83 -0.31 1.36e-8 Crohn's disease;Body mass index; CRC cis rs1707322 1.000 rs4660328 chr1:46444831 G/T cg06784218 chr1:46089804 CCDC17 0.51 8.96 0.44 2.39e-17 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs8060686 0.591 rs80346622 chr16:68074419 C/T cg08314208 chr16:67682810 RLTPR -0.62 -6.51 -0.34 2.78e-10 HDL cholesterol;Metabolic syndrome; CRC cis rs789852 0.867 rs9288751 chr3:194316294 C/G cg21106136 chr3:194405973 FAM43A 0.72 6.02 0.31 4.66e-9 QT interval; CRC cis rs9486715 1.000 rs6902835 chr6:97063005 C/G cg18709589 chr6:96969512 KIAA0776 -0.52 -7.47 -0.38 7.35e-13 Headache; CRC cis rs13118159 0.801 rs7664474 chr4:1329116 T/A cg24560729 chr4:1342394 KIAA1530 0.43 7.81 0.4 7.65e-14 Longevity; CRC cis rs1348850 0.874 rs952746 chr2:178306584 A/G cg02961200 chr2:178257176 LOC100130691;AGPS 0.58 8.48 0.42 7.5e-16 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC trans rs75246769 1.000 rs111654554 chr7:145646556 G/C cg21982490 chr5:124845866 NA -0.67 -6.28 -0.33 1.07e-9 Facial morphology (factor 10, width of nasal floor); CRC cis rs17209837 1.000 rs60123540 chr7:87085182 T/C cg00919237 chr7:87102261 ABCB4 -0.49 -6.03 -0.32 4.4e-9 Gallbladder cancer; CRC cis rs10927875 0.793 rs1763619 chr1:16326935 A/G cg21385522 chr1:16154831 NA 0.64 8.26 0.41 3.49e-15 Dilated cardiomyopathy; CRC cis rs2836974 0.931 rs13047663 chr21:40708818 C/T cg17971929 chr21:40555470 PSMG1 0.66 8.67 0.43 2.01e-16 Cognitive function; CRC cis rs300703 0.719 rs446488 chr2:195365 T/C cg21211680 chr2:198530 NA 0.91 11.94 0.55 1.55e-27 Blood protein levels; CRC cis rs7487075 0.619 rs7134289 chr12:46838336 G/A cg22049899 chr12:47219821 SLC38A4 0.31 5.75 0.3 2.01e-8 Itch intensity from mosquito bite; CRC cis rs7503807 0.967 rs12940622 chr17:78615571 G/A cg09596252 chr17:78655493 RPTOR 0.41 6.36 0.33 6.72e-10 Obesity; CRC cis rs12545109 1.000 rs1975284 chr8:57314663 A/G cg09654669 chr8:57350985 NA -0.37 -6.28 -0.33 1.07e-9 Obesity-related traits; CRC cis rs1950626 0.833 rs12892225 chr14:101415413 T/C cg02351406 chr14:101447389 SNORD114-20;SNORD114-21 0.95 16.01 0.66 4.75e-43 Pelvic organ prolapse (moderate/severe); CRC cis rs28386778 0.897 rs1877318 chr17:61819960 G/A cg22520471 chr17:61851767 DDX42;CCDC47 0.73 11.22 0.53 5.89e-25 Prudent dietary pattern; CRC cis rs7618915 0.501 rs34754793 chr3:52629177 A/T cg08222913 chr3:52553049 STAB1 -0.34 -6.35 -0.33 7.09e-10 Bipolar disorder; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg06720001 chr18:51795815 POLI 0.45 6.05 0.32 4.01e-9 Anxiety disorder; CRC cis rs9747201 0.962 rs35051180 chr17:80135046 G/A cg09264619 chr17:80180166 NA 0.5 7.26 0.37 2.77e-12 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs2072499 0.932 rs3001790 chr1:156165290 T/G cg24450063 chr1:156163899 SLC25A44 1.16 27.43 0.83 5.25e-87 Testicular germ cell tumor; CRC cis rs4692589 0.556 rs13133562 chr4:170965709 C/T cg19918862 chr4:170955249 NA 0.53 6.97 0.36 1.69e-11 Anxiety disorder; CRC cis rs8072100 0.967 rs8075411 chr17:45676760 C/T cg08085267 chr17:45401833 C17orf57 0.61 9.65 0.47 1.44e-19 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs13394619 0.775 rs10200851 chr2:11722082 C/T cg07314298 chr2:11723111 GREB1 -0.48 -8.17 -0.41 6.81e-15 Endometriosis; CRC cis rs7246865 0.603 rs10423719 chr19:17211568 T/C cg19418318 chr19:17219073 MYO9B 0.42 7.53 0.38 4.94e-13 Reticulocyte fraction of red cells; CRC cis rs921968 0.519 rs62191659 chr2:219630510 C/T cg02176678 chr2:219576539 TTLL4 -0.39 -6.32 -0.33 8.67e-10 Mean corpuscular hemoglobin concentration; CRC trans rs7395662 0.963 rs11040016 chr11:48783497 A/G cg21153622 chr11:89784906 NA 0.5 8.08 0.41 1.22e-14 HDL cholesterol; CRC trans rs6956675 1.000 rs1967430 chr7:62599308 C/T cg01314568 chr7:57830625 NA -0.68 -9.27 -0.46 2.56e-18 Obesity-related traits; CRC trans rs453301 0.507 rs2929306 chr8:9084909 C/T cg16141378 chr3:129829833 LOC729375 0.41 6.29 0.33 1.02e-9 Joint mobility (Beighton score); CRC trans rs10411161 0.702 rs7251571 chr19:52389057 A/G cg22319618 chr22:45562946 NUP50 -0.6 -6.85 -0.35 3.54e-11 Breast cancer; CRC cis rs7216064 0.953 rs8073510 chr17:65839210 A/G cg12091567 chr17:66097778 LOC651250 -0.68 -7.87 -0.4 5.31e-14 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CRC cis rs2549003 1.000 rs9282762 chr5:131822055 T/C cg21138405 chr5:131827807 IRF1 0.57 11.38 0.53 1.59e-25 Asthma (sex interaction); CRC cis rs1401999 1.000 rs6443926 chr3:183706630 A/C cg20387954 chr3:183756860 HTR3D 0.43 7.4 0.38 1.14e-12 Anterior chamber depth; CRC cis rs4929949 0.932 rs10840087 chr11:8616255 G/A cg02811074 chr11:8615871 STK33 0.36 6.15 0.32 2.22e-9 Body mass index; CRC cis rs2882667 0.858 rs6596460 chr5:138414180 G/A cg09476006 chr5:138032270 NA 0.41 6.56 0.34 2.06e-10 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs6921919 0.525 rs9468361 chr6:28346318 T/C cg21251018 chr6:28226885 NKAPL 0.39 6.02 0.31 4.74e-9 Autism spectrum disorder or schizophrenia; CRC cis rs4132509 1.000 rs9782958 chr1:243892972 C/G cg21452805 chr1:244014465 NA 0.46 6.48 0.34 3.31e-10 RR interval (heart rate); CRC cis rs13108904 0.557 rs1680030 chr4:1245500 A/T cg24560729 chr4:1342394 KIAA1530 -0.35 -5.69 -0.3 2.81e-8 Obesity-related traits; CRC cis rs7249142 0.562 rs10417796 chr19:19287072 A/G cg08207377 chr19:19281140 LOC729991-MEF2B;MEF2B -0.37 -6.04 -0.32 4.28e-9 IgG glycosylation; CRC cis rs6752107 0.901 rs2289477 chr2:234160345 T/G cg07618928 chr2:234183455 ATG16L1;SCARNA5 0.65 11.38 0.53 1.54e-25 Crohn's disease;Inflammatory bowel disease; CRC cis rs1215050 0.818 rs165238 chr4:98712138 G/T cg05340658 chr4:99064831 C4orf37 0.45 6.67 0.35 1.08e-10 Waist-to-hip ratio adjusted for body mass index; CRC cis rs9443189 0.570 rs504323 chr6:76294965 A/G cg01950844 chr6:76311363 SENP6 -0.7 -8.27 -0.41 3.31e-15 Prostate cancer; CRC cis rs17162190 0.605 rs9438626 chr1:26775367 G/C cg17456097 chr1:26900765 RPS6KA1 0.44 6.28 0.33 1.04e-9 Mean corpuscular volume; CRC cis rs10463316 0.894 rs4099168 chr5:150766467 A/G cg03212797 chr5:150827313 SLC36A1 -0.5 -7.85 -0.4 6.1e-14 Metabolite levels (Pyroglutamine); CRC cis rs35306767 0.855 rs55708963 chr10:925712 C/A cg20503657 chr10:835505 NA 1.18 14.45 0.62 5.3e-37 Eosinophil percentage of granulocytes; CRC cis rs6500602 0.647 rs4786514 chr16:4576798 A/C cg14951292 chr16:4525986 HMOX2;NMRAL1 0.61 8.75 0.43 1.14e-16 Schizophrenia; CRC cis rs2836950 0.501 rs2836983 chr21:40689336 G/A cg06238570 chr21:40685208 BRWD1 -0.6 -8.64 -0.43 2.48e-16 Menarche (age at onset); CRC trans rs7647973 0.593 rs4855885 chr3:49690199 G/A cg21659725 chr3:3221576 CRBN -0.62 -6.45 -0.34 3.95e-10 Menarche (age at onset); CRC cis rs1046896 1.000 rs1046896 chr17:80685533 A/G cg03160526 chr17:80928410 B3GNTL1 -0.48 -7.28 -0.37 2.52e-12 Glycated hemoglobin levels; CRC cis rs853679 0.517 rs7755442 chr6:28039015 T/C cg02683197 chr6:28174875 NA 0.78 9.5 0.46 4.55e-19 Depression; CRC trans rs629535 0.665 rs2433331 chr8:70041943 T/C cg21567404 chr3:27674614 NA 0.97 16.5 0.67 5.22e-45 Dupuytren's disease; CRC cis rs6860806 0.661 rs6871350 chr5:131580220 A/G cg11843238 chr5:131593191 PDLIM4 0.43 8.21 0.41 5.21e-15 Breast cancer; CRC cis rs7586879 0.616 rs12713422 chr2:25134497 A/C cg04586622 chr2:25135609 ADCY3 -0.55 -10.17 -0.49 2.61e-21 Body mass index; CRC cis rs79387448 0.745 rs6742433 chr2:103175360 C/T cg00507830 chr2:103233733 NA 0.54 6.08 0.32 3.36e-9 Gut microbiota (bacterial taxa); CRC cis rs11212617 0.967 rs1003624 chr11:108152645 A/G cg01991180 chr11:108092276 ATM;NPAT 0.42 6.14 0.32 2.42e-9 Response to metformin in type 2 diabetes (glycemic); CRC cis rs1552244 0.882 rs3732967 chr3:10015437 T/C cg10729496 chr3:10149963 C3orf24 0.48 6.25 0.33 1.25e-9 Alzheimer's disease; CRC cis rs7953508 0.711 rs3825199 chr12:93976954 A/G cg18151635 chr12:93972918 NA -0.69 -9.36 -0.46 1.33e-18 Pubertal anthropometrics; CRC cis rs11122272 0.735 rs2808585 chr1:231514218 C/T cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.54 -8.11 -0.41 1.04e-14 Hemoglobin concentration; CRC cis rs11098499 0.866 rs9991221 chr4:120292107 G/C cg24375607 chr4:120327624 NA 0.48 7.48 0.38 6.72e-13 Corneal astigmatism; CRC cis rs2243480 1.000 rs2243480 chr7:65599196 C/T cg12463550 chr7:65579703 CRCP 0.63 5.86 0.31 1.11e-8 Diabetic kidney disease; CRC cis rs28386778 0.897 rs7212196 chr17:61834981 T/C cg22520471 chr17:61851767 DDX42;CCDC47 0.75 11.47 0.53 7.35e-26 Prudent dietary pattern; CRC cis rs644799 1.000 rs518919 chr11:95623313 G/C cg03916912 chr11:95522834 CEP57;FAM76B 0.95 17.8 0.7 4.11e-50 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs6912958 0.781 rs7742965 chr6:88278196 T/C cg12350822 chr6:88032061 C6orf162;GJB7 -0.34 -6.37 -0.33 6.44e-10 Monocyte percentage of white cells; CRC cis rs6952808 0.582 rs10479762 chr7:2045351 T/C cg21782813 chr7:2030301 MAD1L1 -0.45 -8.19 -0.41 5.66e-15 Bipolar disorder and schizophrenia; CRC cis rs75422866 0.510 rs73105818 chr12:48120321 C/T cg14736327 chr12:48174669 SLC48A1 -0.73 -5.8 -0.3 1.6e-8 Pneumonia; CRC trans rs11252926 0.966 rs11252923 chr10:566195 G/A cg00953403 chr17:74099816 EXOC7 -0.45 -6.13 -0.32 2.45e-9 Psychosis in Alzheimer's disease; CRC cis rs9303542 0.625 rs4239209 chr17:46574317 T/A cg04904318 chr17:46607828 HOXB1 0.47 6.11 0.32 2.81e-9 Ovarian cancer;Epithelial ovarian cancer; CRC cis rs2576037 0.526 rs10853547 chr18:44530548 A/C cg23996704 chr18:44553084 KATNAL2 -0.38 -7.59 -0.39 3.26e-13 Personality dimensions; CRC cis rs6952808 0.630 rs10239050 chr7:2158390 A/G cg02951883 chr7:2050386 MAD1L1 -0.69 -11.0 -0.52 3.65e-24 Bipolar disorder and schizophrenia; CRC cis rs11212617 1.000 rs1003623 chr11:108152582 C/T cg01991180 chr11:108092276 ATM;NPAT 0.42 6.14 0.32 2.42e-9 Response to metformin in type 2 diabetes (glycemic); CRC cis rs7647973 0.626 rs1996664 chr3:49878395 A/G cg13072238 chr3:49761600 GMPPB 0.5 5.74 0.3 2.21e-8 Menarche (age at onset); CRC cis rs11168351 0.591 rs4258439 chr12:48468652 A/G cg24011408 chr12:48396354 COL2A1 -0.47 -6.95 -0.36 1.97e-11 Bipolar disorder and schizophrenia; CRC cis rs9303542 0.559 rs55859232 chr17:46612645 A/G cg04904318 chr17:46607828 HOXB1 -0.53 -6.21 -0.32 1.63e-9 Ovarian cancer;Epithelial ovarian cancer; CRC cis rs8016982 0.633 rs55822231 chr14:81708677 C/T cg01989461 chr14:81687754 GTF2A1 0.66 10.68 0.51 4.83e-23 Schizophrenia; CRC cis rs6426558 0.537 rs56219094 chr1:227340191 T/C cg10327440 chr1:227177885 CDC42BPA -0.46 -6.83 -0.35 4.05e-11 Neutrophil percentage of white cells; CRC cis rs9522267 0.559 rs9522300 chr13:112236668 C/G cg10483660 chr13:112241077 NA -0.48 -9.0 -0.44 1.85e-17 Hepatitis; CRC cis rs11098499 0.909 rs79704848 chr4:120309351 T/A cg24375607 chr4:120327624 NA 0.51 7.86 0.4 5.5e-14 Corneal astigmatism; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg27467005 chr19:17622279 PGLS 0.47 5.99 0.31 5.58e-9 Thyroid stimulating hormone; CRC cis rs13108904 0.967 rs11247986 chr4:1294347 G/A cg19318889 chr4:1322082 MAEA 0.41 5.83 0.31 1.29e-8 Obesity-related traits; CRC cis rs7474896 0.609 rs11011336 chr10:37985316 A/G cg25427524 chr10:38739819 LOC399744 -0.59 -7.29 -0.37 2.39e-12 Obesity (extreme); CRC trans rs916888 0.773 rs1378358 chr17:44787312 C/T cg07870213 chr5:140052090 DND1 1.01 10.95 0.52 5.4e-24 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC trans rs2303319 0.504 rs58622044 chr2:162596287 A/G cg23919916 chr10:103825097 HPS6 -0.69 -5.99 -0.31 5.59e-9 Cognitive function; CRC cis rs10479542 0.784 rs6601050 chr5:178986261 C/G cg14820908 chr5:178986412 RUFY1 -0.39 -6.77 -0.35 5.83e-11 Lung cancer; CRC cis rs7208859 0.673 rs9913782 chr17:29237384 A/G cg14008862 chr17:28927542 LRRC37B2 0.56 5.8 0.3 1.6e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs651907 0.535 rs1460097 chr3:101497569 C/T cg12386194 chr3:101231763 SENP7 0.5 7.37 0.38 1.41e-12 Colorectal cancer; CRC cis rs35110281 0.713 rs1378079 chr21:45011187 A/G cg01579765 chr21:45077557 HSF2BP -0.35 -6.65 -0.34 1.24e-10 Mean corpuscular volume; CRC trans rs10504229 1.000 rs57624567 chr8:58176995 T/C cg04077850 chr5:125800366 GRAMD3 0.37 6.27 0.33 1.15e-9 Developmental language disorder (linguistic errors); CRC cis rs10504229 0.906 rs17805439 chr8:58172400 T/C cg24829409 chr8:58192753 C8orf71 -0.68 -11.34 -0.53 2.27e-25 Developmental language disorder (linguistic errors); CRC cis rs12900413 0.603 rs12906832 chr15:90301314 C/G cg24249390 chr15:90295951 MESP1 -0.61 -9.28 -0.46 2.26e-18 Coronary artery aneurysm in Kawasaki disease; CRC cis rs853679 0.517 rs6941992 chr6:28106141 T/C cg25164649 chr6:28176230 NA 0.76 9.53 0.46 3.71e-19 Depression; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg26771998 chr10:75490334 BMS1P4 0.43 6.71 0.35 8.47e-11 Liver disease severity in Alagille syndrome; CRC cis rs1218582 0.710 rs9793588 chr1:154878878 C/G cg16680214 chr1:154839983 KCNN3 -0.46 -8.93 -0.44 3.15e-17 Prostate cancer; CRC cis rs4843747 0.671 rs28679286 chr16:88106307 C/T cg03395651 chr16:88107091 BANP 0.6 8.16 0.41 7.06e-15 Menopause (age at onset); CRC cis rs1348850 0.526 rs6723014 chr2:178410586 G/A cg27490568 chr2:178487706 NA 0.61 7.25 0.37 3.05e-12 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC trans rs3733585 0.699 rs6449177 chr4:9968050 T/C cg26043149 chr18:55253948 FECH -0.49 -7.48 -0.38 6.61e-13 Cleft plate (environmental tobacco smoke interaction); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg27037990 chr4:184427250 ING2 0.41 7.36 0.38 1.48e-12 Liver disease severity in Alagille syndrome; CRC cis rs9858542 0.953 rs9862080 chr3:49674458 A/G cg00383909 chr3:49044727 WDR6 0.49 6.16 0.32 2.08e-9 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs6570726 0.577 rs403345 chr6:145845171 T/C cg05347473 chr6:146136440 FBXO30 0.48 7.09 0.36 8.08e-12 Lobe attachment (rater-scored or self-reported); CRC cis rs477895 0.653 rs72918475 chr11:63878644 G/C cg19465662 chr11:63993652 NUDT22;TRPT1 0.71 8.43 0.42 1.09e-15 Mean platelet volume; CRC cis rs4716602 0.596 rs28451598 chr7:156158974 G/A cg16983916 chr7:156159713 NA -0.39 -6.97 -0.36 1.74e-11 Anti-saccade response; CRC cis rs7772486 0.806 rs2247317 chr6:146217570 C/T cg23711669 chr6:146136114 FBXO30 0.64 11.04 0.52 2.61e-24 Lobe attachment (rater-scored or self-reported); CRC cis rs12497850 0.931 rs4974080 chr3:49030828 A/C cg20833759 chr3:49053208 WDR6;DALRD3 0.51 8.74 0.43 1.21e-16 Parkinson's disease; CRC cis rs832540 0.669 rs173764 chr5:56198920 C/T cg18230493 chr5:56204884 C5orf35 -0.51 -7.43 -0.38 9.74e-13 Coronary artery disease; CRC cis rs6121246 0.909 rs1994250 chr20:30287494 A/G cg13852791 chr20:30311386 BCL2L1 0.68 10.95 0.52 5.15e-24 Mean corpuscular hemoglobin; CRC cis rs7580658 0.613 rs12463538 chr2:128196854 G/T cg09760422 chr2:128146352 NA -0.31 -5.68 -0.3 2.89e-8 Protein C levels; CRC trans rs61931739 0.500 rs10844863 chr12:34532284 C/T cg26384229 chr12:38710491 ALG10B 0.59 8.77 0.44 9.64e-17 Morning vs. evening chronotype; CRC cis rs6952808 0.595 rs3778982 chr7:2166233 T/C cg04267008 chr7:1944627 MAD1L1 -0.69 -9.44 -0.46 7.09e-19 Bipolar disorder and schizophrenia; CRC cis rs2304206 0.614 rs12104272 chr19:50148052 A/G cg09250473 chr19:50168907 IRF3;BCL2L12 -0.52 -7.6 -0.39 3.06e-13 Vitiligo; CRC cis rs4561483 0.514 rs33639 chr16:11989499 A/C cg08843971 chr16:11963173 GSPT1 -0.46 -6.76 -0.35 6.3e-11 Testicular germ cell tumor; CRC cis rs10499694 0.933 rs7778349 chr7:50593157 C/T cg14593290 chr7:50529359 DDC -0.43 -6.29 -0.33 1.03e-9 Body mass index; CRC cis rs853679 0.517 rs9295758 chr6:28120663 C/G cg23161317 chr6:28129485 ZNF389 0.53 6.43 0.33 4.52e-10 Depression; CRC cis rs7107174 1.000 rs10899475 chr11:78051610 T/C cg02023728 chr11:77925099 USP35 0.49 8.4 0.42 1.4e-15 Testicular germ cell tumor; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg27114086 chr1:155658701 YY1AP1;DAP3 0.45 6.29 0.33 1.02e-9 Response to antipsychotic treatment; CRC trans rs2303319 0.504 rs62188988 chr2:162531068 T/C cg07972541 chr16:28961971 NFATC2IP -0.71 -6.01 -0.31 4.8e-9 Cognitive function; CRC cis rs7647973 1.000 rs62259933 chr3:49469703 G/A cg07690219 chr3:49449608 TCTA;RHOA 0.5 5.63 0.3 3.89e-8 Menarche (age at onset); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg17546822 chr22:41865178 ACO2;PHF5A 0.47 6.93 0.36 2.28e-11 Intelligence (multi-trait analysis); CRC cis rs7666738 0.830 rs114722517 chr4:99042061 G/A cg05340658 chr4:99064831 C4orf37 0.6 9.35 0.46 1.36e-18 Colonoscopy-negative controls vs population controls; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg02590856 chr6:117923645 GOPC 0.44 6.0 0.31 5.17e-9 Anxiety disorder; CRC cis rs2364543 0.624 rs61774752 chr1:41847024 T/C cg00290994 chr1:41848739 NA 0.56 8.54 0.43 5.11e-16 Intelligence (multi-trait analysis); CRC cis rs3864277 0.510 rs31478 chr5:131423475 T/C cg02033258 chr5:131593261 PDLIM4 0.33 6.01 0.31 4.79e-9 Itch intensity from mosquito bite adjusted by bite size; CRC cis rs887829 0.570 rs6753569 chr2:234595817 A/C cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.46 -7.13 -0.37 6.28e-12 Metabolic traits;Bilirubin levels;Cholelithiasis-related traits in sickle cell anemia;Metabolite levels;Total bilirubin levels in HIV-1 infection;Serum metabolite levels;Blood metabolite levels; CRC cis rs754466 0.606 rs10824581 chr10:79599501 A/G cg26805224 chr10:79626177 DLG5 -0.52 -7.43 -0.38 9.54e-13 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs6500602 0.627 rs860891 chr16:4586529 C/T cg14951292 chr16:4525986 HMOX2;NMRAL1 -0.6 -8.87 -0.44 4.86e-17 Schizophrenia; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg05742354 chr1:10856609 CASZ1 0.43 6.23 0.32 1.4e-9 Intelligence (multi-trait analysis); CRC cis rs4665809 0.590 rs6749046 chr2:26429451 C/G cg04944784 chr2:26401820 FAM59B 0.83 10.84 0.51 1.31e-23 Gut microbiome composition (summer); CRC cis rs1448094 0.512 rs11117060 chr12:86250788 G/T cg18827107 chr12:86230957 RASSF9 0.45 7.58 0.39 3.54e-13 Major depressive disorder; CRC cis rs875971 0.862 rs801209 chr7:66019390 G/T cg11764359 chr7:65958608 NA -0.59 -8.81 -0.44 7.57e-17 Aortic root size; CRC cis rs11971779 0.618 rs6943788 chr7:139087697 C/T cg07862535 chr7:139043722 LUC7L2 0.57 7.35 0.38 1.61e-12 Diisocyanate-induced asthma; CRC cis rs7715806 0.500 rs17563610 chr5:74981322 A/T cg19683494 chr5:74908142 NA 0.6 6.84 0.35 3.86e-11 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs7618501 0.602 rs6780731 chr3:50017478 A/G cg24308560 chr3:49941425 MST1R -0.51 -8.26 -0.41 3.49e-15 Intelligence (multi-trait analysis); CRC cis rs9372498 0.536 rs9489458 chr6:118920503 G/A cg10217327 chr6:118973057 C6orf204 0.52 5.92 0.31 8.31e-9 Diastolic blood pressure; CRC cis rs10504229 0.953 rs57669205 chr8:58172253 T/C cg24829409 chr8:58192753 C8orf71 -0.68 -11.31 -0.53 2.72e-25 Developmental language disorder (linguistic errors); CRC cis rs1862618 0.853 rs252898 chr5:56188931 T/C cg24531977 chr5:56204891 C5orf35 -0.86 -11.11 -0.52 1.51e-24 Initial pursuit acceleration; CRC cis rs2153535 0.580 rs1414344 chr6:8471365 C/A cg07606381 chr6:8435919 SLC35B3 0.67 10.79 0.51 1.94e-23 Motion sickness; CRC cis rs11958404 0.932 rs111802867 chr5:157424971 G/A cg05962755 chr5:157440814 NA 1.01 12.84 0.58 7.03e-31 IgG glycosylation; CRC cis rs116095464 0.867 rs7726582 chr5:215349 C/G cg22496380 chr5:211416 CCDC127 -0.83 -9.45 -0.46 6.42e-19 Breast cancer; CRC trans rs6048205 1.000 rs2277763 chr20:22548294 C/T cg09295799 chr6:5994235 NA -0.62 -6.12 -0.32 2.59e-9 Fasting blood glucose (BMI interaction);Fasting blood glucose; CRC cis rs10504229 0.683 rs1495866 chr8:58141128 T/C cg05313129 chr8:58192883 C8orf71 -0.43 -6.11 -0.32 2.74e-9 Developmental language disorder (linguistic errors); CRC cis rs12477438 0.798 rs1580068 chr2:99649969 T/C cg26064155 chr2:99771622 LIPT1;TSGA10 -0.79 -11.26 -0.53 4.44e-25 Chronic sinus infection; CRC cis rs2573652 0.722 rs12904962 chr15:100544113 A/G cg00587665 chr15:100533223 ADAMTS17 0.39 6.92 0.36 2.31e-11 Height; CRC cis rs1129187 0.755 rs9471986 chr6:42944127 A/G cg03790207 chr6:42947109 PEX6 -0.52 -7.6 -0.39 3.16e-13 Alzheimer's disease in APOE e4+ carriers; CRC cis rs12188164 1.000 rs56104584 chr5:437542 T/C cg21972741 chr5:435613 AHRR 0.53 7.37 0.38 1.41e-12 Cystic fibrosis severity; CRC trans rs16846053 0.786 rs72873645 chr2:162495047 G/A cg23247704 chr1:116518985 SLC22A15 -0.7 -6.04 -0.32 4.14e-9 Blood osmolality (transformed sodium); CRC cis rs908922 0.676 rs11205033 chr1:152527966 C/A cg23254163 chr1:152506842 NA 0.49 9.69 0.47 1.07e-19 Hair morphology; CRC cis rs929354 0.772 rs3802117 chr7:156987000 C/T cg17757837 chr7:157058334 UBE3C 0.74 12.6 0.57 5.83e-30 Body mass index; CRC cis rs425277 0.583 rs1467217 chr1:2045165 G/A cg19257562 chr1:2043853 PRKCZ 0.38 6.42 0.33 4.66e-10 Height; CRC cis rs6921919 0.559 rs13210866 chr6:28383842 G/A cg21251018 chr6:28226885 NKAPL 0.4 6.01 0.31 4.96e-9 Autism spectrum disorder or schizophrenia; CRC cis rs4925325 0.955 rs1776262 chr20:60516023 G/T cg18761221 chr20:60518478 NA -0.7 -12.65 -0.57 3.57e-30 Obesity-related traits; CRC cis rs7786808 0.741 rs7789415 chr7:158227617 C/T cg01191920 chr7:158217561 PTPRN2 -0.89 -16.76 -0.68 5.06e-46 Obesity-related traits; CRC cis rs13096480 0.583 rs17598137 chr3:49891362 G/T cg06222517 chr3:49577284 NA 0.4 5.89 0.31 9.54e-9 Intelligence (multi-trait analysis); CRC cis rs17376456 0.877 rs12716460 chr5:93416733 A/G cg25358565 chr5:93447407 FAM172A 1.02 10.47 0.5 2.42e-22 Diabetic retinopathy; CRC cis rs2153535 0.580 rs6937186 chr6:8494493 A/C cg21535247 chr6:8435926 SLC35B3 0.5 7.55 0.38 4.4e-13 Motion sickness; CRC cis rs3888647 0.561 rs4758617 chr11:2995185 T/A cg05729581 chr11:3078854 CARS -0.51 -7.48 -0.38 6.84e-13 Type 2 diabetes; CRC cis rs7666738 0.830 rs4699600 chr4:99019429 C/G cg17366294 chr4:99064904 C4orf37 0.43 7.29 0.37 2.28e-12 Colonoscopy-negative controls vs population controls; CRC cis rs2228479 0.717 rs17233678 chr16:89809962 T/C cg06558623 chr16:89946397 TCF25 1.14 10.79 0.51 1.99e-23 Skin colour saturation; CRC cis rs12950390 0.893 rs12325760 chr17:45840886 C/T cg24803719 chr17:45855879 NA -0.3 -6.54 -0.34 2.3e-10 IgG glycosylation; CRC cis rs524281 0.731 rs3829937 chr11:65787666 G/A cg16950941 chr11:66035639 RAB1B -0.55 -6.01 -0.31 4.81e-9 Electroencephalogram traits; CRC cis rs13108904 0.846 rs3775100 chr4:1225106 T/C cg20092199 chr4:1342459 KIAA1530 0.36 6.45 0.34 3.88e-10 Obesity-related traits; CRC cis rs2839186 0.709 rs2839176 chr21:47678173 A/G cg05896524 chr21:47604654 C21orf56 0.46 6.8 0.35 4.87e-11 Testicular germ cell tumor; CRC cis rs8072100 0.713 rs9899859 chr17:45513049 A/G cg25173405 chr17:45401733 C17orf57 -0.43 -6.44 -0.33 4.13e-10 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs9381040 0.610 rs2235679 chr6:41020577 G/T cg03644281 chr6:41068752 NFYA;LOC221442 -0.44 -6.37 -0.33 6.31e-10 Alzheimer's disease (late onset); CRC cis rs727479 0.502 rs8029120 chr15:51504934 A/C cg19946085 chr15:51559439 CYP19A1 -0.3 -6.02 -0.31 4.66e-9 Estradiol levels; CRC cis rs4731207 0.698 rs6968187 chr7:124563340 T/G cg23710748 chr7:124431027 NA -0.37 -5.99 -0.31 5.5e-9 Cutaneous malignant melanoma; CRC cis rs863345 0.604 rs7548349 chr1:158493726 C/T cg12129480 chr1:158549410 OR10X1 -0.29 -5.95 -0.31 7e-9 Pneumococcal bacteremia; CRC cis rs7617773 0.539 rs2017858 chr3:48382282 G/T cg11946769 chr3:48343235 NME6 0.6 8.16 0.41 6.96e-15 Coronary artery disease; CRC cis rs9611565 0.694 rs202637 chr22:41853928 A/G cg06634786 chr22:41940651 POLR3H 0.64 6.94 0.36 2.09e-11 Vitiligo; CRC cis rs995000 0.929 rs636523 chr1:62920008 A/G cg19896129 chr1:63156450 NA 0.43 6.38 0.33 5.93e-10 Triglyceride levels; CRC trans rs1728785 1.000 rs8058145 chr16:68584090 G/A cg04657470 chr2:198365150 HSPE1;HSPD1 0.58 7.07 0.36 9.08e-12 Ulcerative colitis; CRC cis rs17253792 0.822 rs75016910 chr14:56050466 C/G cg01858014 chr14:56050164 KTN1 -0.88 -7.09 -0.36 8.36e-12 Putamen volume; CRC trans rs2727020 0.894 rs3862342 chr11:49357043 C/T cg03929089 chr4:120376271 NA -0.72 -9.58 -0.47 2.55e-19 Coronary artery disease; CRC cis rs2645694 0.626 rs2645708 chr4:77822682 G/A cg03477792 chr4:77819574 ANKRD56 0.44 6.47 0.34 3.55e-10 Emphysema distribution in smoking; CRC cis rs13191362 1.000 rs7764785 chr6:163009967 A/G cg23758597 chr6:163146217 PARK2 -0.55 -6.12 -0.32 2.7e-9 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC trans rs853679 0.599 rs149990 chr6:27998258 G/A cg06606381 chr12:133084897 FBRSL1 -0.8 -7.5 -0.38 6.11e-13 Depression; CRC cis rs60843830 1.000 rs62114501 chr2:231741 C/T cg25945732 chr2:264204 ACP1;SH3YL1 0.74 12.18 0.56 1.97e-28 Spherical equivalent (joint analysis main effects and education interaction); CRC trans rs1455244 0.700 rs7229302 chr18:11508904 G/T cg06044117 chr11:95523445 FAM76B;CEP57 0.43 6.36 0.33 6.59e-10 Schizophrenia; CRC cis rs7208859 0.524 rs60114476 chr17:29097667 A/T cg01831904 chr17:28903510 LRRC37B2 -0.63 -6.53 -0.34 2.51e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC trans rs8177876 0.642 rs56032321 chr16:81117906 A/C cg09779152 chr17:73205364 NUP85 0.61 5.98 0.31 5.79e-9 Plasma omega-3 polyunsaturated fatty acid level (eicosapentaenoic acid); CRC cis rs599083 0.530 rs640569 chr11:68184820 A/G cg01657329 chr11:68192670 LRP5 0.49 6.94 0.36 2.03e-11 Bone mineral density (spine); CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg14309501 chr19:17445715 ANO8 -0.39 -6.1 -0.32 2.92e-9 Myopia (pathological); CRC cis rs6952808 0.823 rs10950448 chr7:1966492 G/C cg20295408 chr7:1910781 MAD1L1 -0.42 -5.6 -0.3 4.47e-8 Bipolar disorder and schizophrenia; CRC cis rs12681287 0.517 rs68008113 chr8:87520894 C/A cg27223183 chr8:87520930 FAM82B -0.56 -7.74 -0.39 1.22e-13 Caudate activity during reward; CRC cis rs9322193 0.886 rs4039600 chr6:149897455 A/G cg07701084 chr6:150067640 NUP43 0.46 6.54 0.34 2.39e-10 Lung cancer; CRC cis rs561341 0.941 rs4525554 chr17:30312819 T/C cg23018236 chr17:30244563 NA -0.67 -8.02 -0.4 1.83e-14 Hip circumference adjusted for BMI; CRC cis rs9400239 0.584 rs1268178 chr6:109017284 T/G cg11073813 chr6:109029018 NA -0.38 -5.96 -0.31 6.61e-9 Waist circumference;Body mass index;BMI (adjusted for smoking behaviour); CRC trans rs629535 0.734 rs542288 chr8:70057149 G/T cg21567404 chr3:27674614 NA -0.92 -15.34 -0.65 1.92e-40 Dupuytren's disease; CRC cis rs1865760 0.613 rs9379801 chr6:25901711 T/C cg03517284 chr6:25882590 NA -0.45 -6.64 -0.34 1.32e-10 Height; CRC cis rs12580194 1.000 rs7308316 chr12:55709162 T/A cg19537932 chr12:55886519 OR6C68 -0.6 -8.39 -0.42 1.45e-15 Cancer; CRC cis rs2115536 1.000 rs7163338 chr15:80198408 C/G cg00225070 chr15:80189496 MTHFS 0.5 8.09 0.41 1.16e-14 Eosinophil counts;Eosinophil percentage of white cells;Sum eosinophil basophil counts;Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; CRC cis rs2932538 0.922 rs6671645 chr1:113129128 A/G cg22162597 chr1:113214053 CAPZA1 0.61 9.1 0.45 9.08e-18 Systolic blood pressure;Diastolic blood pressure;Hypertension;Blood pressure; CRC cis rs10870270 0.957 rs9971084 chr10:133788747 G/C cg08754478 chr10:133766260 PPP2R2D -0.66 -9.26 -0.45 2.78e-18 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; CRC cis rs877282 1.000 rs877281 chr10:771557 T/G cg17470449 chr10:769945 NA 0.63 8.43 0.42 1.11e-15 Uric acid levels; CRC cis rs703970 0.560 rs1250576 chr10:80964796 A/C cg20744163 chr10:80999841 ZMIZ1 -0.37 -6.08 -0.32 3.37e-9 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs12048904 0.595 rs10493937 chr1:101342650 A/T cg16556008 chr1:101360663 SLC30A7;EXTL2 -0.77 -12.31 -0.56 6.46e-29 Multiple sclerosis; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg01524091 chr6:44281032 AARS2 0.39 6.1 0.32 2.95e-9 Liver disease severity in Alagille syndrome; CRC cis rs3015497 0.616 rs4901044 chr14:51090295 A/G cg09863266 chr14:51125203 SAV1 -0.3 -5.76 -0.3 1.93e-8 Mean platelet volume; CRC cis rs12980942 0.810 rs8105901 chr19:41792092 T/A cg25627403 chr19:41769009 HNRNPUL1 0.56 6.26 0.33 1.21e-9 Coronary artery disease; CRC cis rs12908161 1.000 rs34570071 chr15:85280212 T/A cg17507749 chr15:85114479 UBE2QP1 0.65 9.55 0.47 2.98e-19 Schizophrenia; CRC cis rs7932354 0.710 rs6485702 chr11:46898771 T/C cg19486271 chr11:47235900 DDB2 -0.46 -7.38 -0.38 1.29e-12 Bone mineral density (hip);Bone mineral density; CRC cis rs7811142 1.000 rs6975514 chr7:100056220 T/C cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.63 8.24 0.41 4.27e-15 Platelet count; CRC cis rs7412746 0.611 rs4970984 chr1:150887377 T/C cg17724175 chr1:150552817 MCL1 0.4 6.14 0.32 2.37e-9 Melanoma; CRC cis rs12824058 0.831 rs12310049 chr12:130811260 C/G cg26677194 chr12:130822605 PIWIL1 0.45 7.19 0.37 4.42e-12 Menopause (age at onset); CRC cis rs3749237 0.595 rs885592 chr3:49497883 T/G cg02487422 chr3:49467188 NICN1 0.43 6.91 0.36 2.5e-11 Resting heart rate; CRC cis rs35306767 0.714 rs67205460 chr10:1090366 C/T cg20503657 chr10:835505 NA 0.83 9.88 0.48 2.57e-20 Eosinophil percentage of granulocytes; CRC trans rs2243480 0.803 rs36004293 chr7:65416512 T/C cg10756647 chr7:56101905 PSPH 0.73 8.05 0.41 1.58e-14 Diabetic kidney disease; CRC cis rs2992756 0.663 rs2992757 chr1:18807137 T/C cg14356550 chr1:18808102 KLHDC7A -0.39 -5.86 -0.31 1.14e-8 Breast cancer; CRC trans rs931812 0.895 rs965625 chr8:101909749 T/C cg20993868 chr7:22813445 NA 0.55 10.04 0.48 6.97e-21 Attention deficit hyperactivity disorder and conduct disorder; CRC cis rs2857891 0.695 rs2857887 chr11:6984001 A/G cg22096450 chr11:6947773 ZNF215 0.5 5.93 0.31 7.53e-9 Response to cytadine analogues (cytosine arabinoside); CRC cis rs8072100 0.875 rs9635762 chr17:45648446 A/C cg08085267 chr17:45401833 C17orf57 0.62 10.04 0.48 7.47e-21 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs1799949 0.930 rs1554063 chr17:41287145 T/C cg19454999 chr17:41278357 BRCA1;NBR2 0.4 6.17 0.32 1.99e-9 Menopause (age at onset); CRC cis rs2976388 0.556 rs4736300 chr8:143829269 C/T cg24634471 chr8:143751801 JRK -0.5 -6.91 -0.36 2.49e-11 Urinary tract infection frequency; CRC cis rs5758511 0.773 rs62240999 chr22:42355563 C/G cg00645731 chr22:42541494 CYP2D7P1 0.47 6.97 0.36 1.77e-11 Birth weight; CRC cis rs2739330 0.627 rs9608219 chr22:24274119 G/C cg09033563 chr22:24373618 LOC391322 -0.47 -6.67 -0.35 1.07e-10 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs10089 0.953 rs6875982 chr5:127529197 A/C cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.69 9.71 0.47 9.26e-20 Ileal carcinoids; CRC cis rs60843830 0.596 rs17041320 chr2:112051 A/G cg25945732 chr2:264204 ACP1;SH3YL1 0.43 6.13 0.32 2.5e-9 Spherical equivalent (joint analysis main effects and education interaction); CRC cis rs2569991 0.588 rs62240725 chr3:12929360 A/G cg22481960 chr3:13008800 IQSEC1 0.45 5.82 0.31 1.37e-8 Periodontitis (DPAL); CRC cis rs7953508 0.750 rs11107119 chr12:93983132 T/A cg18151635 chr12:93972918 NA -0.7 -9.47 -0.46 5.6e-19 Pubertal anthropometrics; CRC cis rs4919087 0.961 rs11189120 chr10:99069493 G/T cg25902810 chr10:99078978 FRAT1 0.39 5.98 0.31 5.73e-9 Monocyte count; CRC cis rs17270561 0.666 rs3923725 chr6:25734920 C/A cg17691542 chr6:26056736 HIST1H1C 0.74 9.27 0.45 2.6e-18 Iron status biomarkers; CRC cis rs7173743 0.518 rs12899452 chr15:79112550 T/A cg15571903 chr15:79123663 NA 0.31 6.18 0.32 1.95e-9 Coronary artery disease; CRC cis rs6951245 0.938 rs78351779 chr7:1097023 G/C cg26224354 chr7:1096374 C7orf50;GPR146 -0.93 -12.11 -0.56 3.59e-28 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs9291683 0.588 rs2240724 chr4:10021290 G/C cg11266682 chr4:10021025 SLC2A9 0.53 11.36 0.53 1.81e-25 Bone mineral density; CRC cis rs1448094 0.836 rs7484454 chr12:86425576 A/G cg18827107 chr12:86230957 RASSF9 -0.36 -5.67 -0.3 3.05e-8 Major depressive disorder; CRC cis rs17826219 0.706 rs57698184 chr17:29064918 T/C cg13385521 chr17:29058706 SUZ12P 0.7 7.95 0.4 3.04e-14 Body mass index; CRC cis rs3820068 0.603 rs17448778 chr1:15985306 A/G cg24675056 chr1:15929824 NA 0.5 7.19 0.37 4.29e-12 Systolic blood pressure; CRC cis rs4654899 0.965 rs61781115 chr1:21322860 C/T cg02927042 chr1:21476669 EIF4G3 -0.49 -7.84 -0.4 6.24e-14 Superior frontal gyrus grey matter volume; CRC cis rs2976388 0.609 rs2572908 chr8:143802636 A/G cg05569086 chr8:143859399 LYNX1 0.37 6.35 0.33 7.33e-10 Urinary tract infection frequency; CRC cis rs7044106 0.762 rs12003646 chr9:123470621 A/G cg14255062 chr9:123606675 PSMD5;LOC253039 0.46 6.61 0.34 1.54e-10 Hip circumference adjusted for BMI; CRC cis rs10540 1.000 rs35874808 chr11:506442 G/T cg03576123 chr11:487126 PTDSS2 -1.04 -10.73 -0.51 3.15e-23 Body mass index; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg08171195 chr1:155214570 GBA 0.42 5.97 0.31 6e-9 Intelligence (multi-trait analysis); CRC cis rs9462027 0.628 rs6937314 chr6:34799308 T/G cg07306190 chr6:34760872 UHRF1BP1 -0.34 -6.09 -0.32 3.16e-9 Systemic lupus erythematosus; CRC cis rs7772486 0.840 rs11155451 chr6:146422524 A/G cg23711669 chr6:146136114 FBXO30 0.67 11.61 0.54 2.38e-26 Lobe attachment (rater-scored or self-reported); CRC cis rs9467773 0.550 rs4712987 chr6:26399615 A/C cg09904177 chr6:26538194 HMGN4 -0.45 -6.23 -0.32 1.45e-9 Intelligence (multi-trait analysis); CRC cis rs4319547 1.000 rs7307735 chr12:123087442 A/G cg05707623 chr12:122985044 ZCCHC8 -0.71 -8.88 -0.44 4.49e-17 Body mass index; CRC trans rs10982213 0.830 rs2274163 chr9:117188714 C/T cg18484507 chr14:67982176 TMEM229B 0.38 5.99 0.31 5.42e-9 Interleukin-6 levels; CRC cis rs10504229 0.683 rs11787247 chr8:58131528 G/T cg05313129 chr8:58192883 C8orf71 -0.43 -6.11 -0.32 2.74e-9 Developmental language disorder (linguistic errors); CRC cis rs9309473 1.000 rs9653557 chr2:73795962 A/C cg20560298 chr2:73613845 ALMS1 -0.47 -5.81 -0.3 1.5e-8 Metabolite levels; CRC cis rs12701220 0.689 rs12701824 chr7:1102364 G/A cg00990874 chr7:1149470 C7orf50 -0.5 -5.8 -0.3 1.58e-8 Bronchopulmonary dysplasia; CRC cis rs9311474 0.629 rs7636227 chr3:52566682 G/A cg01758942 chr3:52551074 STAB1 0.3 5.93 0.31 7.76e-9 Electroencephalogram traits; CRC cis rs6951245 0.872 rs75398423 chr7:1098414 T/G cg21664854 chr7:1097933 C7orf50;GPR146 0.77 8.8 0.44 7.85e-17 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC trans rs7647973 0.710 rs11130207 chr3:49611666 T/G cg21659725 chr3:3221576 CRBN -0.69 -7.14 -0.37 6.11e-12 Menarche (age at onset); CRC trans rs11800820 0.567 rs3124116 chr1:246707051 G/C cg26885821 chr6:124125002 NKAIN2 0.37 5.99 0.31 5.65e-9 Obesity-related traits; CRC cis rs7119 0.717 rs11630916 chr15:77821331 G/A cg10437265 chr15:77819839 NA 0.69 12.66 0.57 3.27e-30 Type 2 diabetes; CRC trans rs7618501 0.633 rs55751738 chr3:49972101 A/G cg21659725 chr3:3221576 CRBN 0.54 8.45 0.42 9.28e-16 Intelligence (multi-trait analysis); CRC cis rs2361718 0.501 rs11869566 chr17:78143248 T/C cg14949292 chr17:78079608 GAA -0.41 -5.6 -0.3 4.44e-8 Yeast infection; CRC cis rs17767294 0.612 rs9461425 chr6:27919688 G/A cg25164649 chr6:28176230 NA 0.64 6.58 0.34 1.84e-10 Parkinson's disease; CRC cis rs561341 1.000 rs535151 chr17:30317405 C/T cg19193384 chr17:30244184 NA -0.49 -6.73 -0.35 7.54e-11 Hip circumference adjusted for BMI; CRC cis rs6964587 1.000 rs411 chr7:91557758 C/G cg17063962 chr7:91808500 NA -0.77 -13.0 -0.58 1.76e-31 Breast cancer; CRC cis rs67478160 0.634 rs1955660 chr14:104229985 C/T cg01849466 chr14:104193079 ZFYVE21 -0.53 -9.84 -0.48 3.29e-20 Schizophrenia; CRC cis rs4253772 0.591 rs6007732 chr22:46652303 A/T cg03482458 chr22:46692211 CN5H6.4;GTSE1 0.5 6.6 0.34 1.63e-10 LDL cholesterol;Cholesterol, total; CRC cis rs1448094 0.836 rs6539935 chr12:86376809 T/C cg18827107 chr12:86230957 RASSF9 -0.37 -5.91 -0.31 8.45e-9 Major depressive disorder; CRC cis rs748404 0.697 rs493444 chr15:43566470 G/C cg02155558 chr15:43621948 ADAL;LCMT2 0.44 6.55 0.34 2.15e-10 Lung cancer; CRC cis rs17023223 0.537 rs2765530 chr1:119584396 G/A cg05756136 chr1:119680316 WARS2 -0.47 -6.33 -0.33 7.91e-10 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for BMI in active individuals; CRC cis rs6997458 0.713 rs703 chr8:86389403 T/C cg21346043 chr8:86351067 CA3 -0.26 -5.76 -0.3 1.95e-8 Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; CRC cis rs12451471 0.637 rs7567 chr17:78093549 G/T cg18972013 chr17:78078605 GAA -0.39 -5.62 -0.3 4e-8 Plateletcrit;Mean corpuscular hemoglobin concentration; CRC trans rs1973993 0.717 rs56209707 chr1:96972973 C/A cg10631902 chr5:14652156 NA -0.42 -7.0 -0.36 1.44e-11 Weight; CRC cis rs12477438 0.765 rs6722164 chr2:99561527 C/T cg14399236 chr2:99771627 LIPT1;TSGA10 -0.59 -8.16 -0.41 6.96e-15 Chronic sinus infection; CRC cis rs9534288 0.797 rs9534282 chr13:46588944 T/C cg15192986 chr13:46630673 CPB2 -0.67 -9.85 -0.48 3.16e-20 Blood protein levels; CRC cis rs9303542 0.625 rs4793889 chr17:46592352 A/G cg04904318 chr17:46607828 HOXB1 0.48 6.21 0.32 1.64e-9 Ovarian cancer;Epithelial ovarian cancer; CRC cis rs6681460 0.966 rs10889644 chr1:67145322 C/A cg02459107 chr1:67143332 SGIP1 0.45 8.25 0.41 3.95e-15 Presence of antiphospholipid antibodies; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg03392900 chr1:1167310 SDF4;B3GALT6 0.47 6.27 0.33 1.13e-9 Anxiety disorder; CRC cis rs853679 0.882 rs9461432 chr6:28086883 T/C cg15845792 chr6:28175446 NA 0.8 6.52 0.34 2.67e-10 Depression; CRC cis rs67311347 1.000 rs4246666 chr3:40407670 C/T cg09455208 chr3:40491958 NA 0.43 8.9 0.44 3.69e-17 Renal cell carcinoma; CRC cis rs7833986 0.501 rs2719245 chr8:56894359 G/C cg23139584 chr8:56987506 RPS20;SNORD54 0.79 11.35 0.53 2e-25 Height; CRC cis rs7412746 0.658 rs12410394 chr1:150860186 G/A cg18016565 chr1:150552671 MCL1 0.41 5.75 0.3 2.01e-8 Melanoma; CRC cis rs317865 0.737 rs16893153 chr4:16181798 T/C cg04764131 chr4:16228633 TAPT1;FLJ39653 0.55 5.99 0.31 5.4e-9 Kidney disease (early stage) in type 1 diabetes; CRC trans rs11264213 0.711 rs489534 chr1:36155418 C/T cg07175433 chr4:21947400 KCNIP4 -0.37 -6.36 -0.33 6.71e-10 Schizophrenia; CRC cis rs734999 0.545 rs10797441 chr1:2551660 T/G cg20673091 chr1:2541236 MMEL1 0.36 5.82 0.31 1.39e-8 Ulcerative colitis; CRC trans rs6693295 0.729 rs2185073 chr1:246213341 G/A cg17980625 chr11:94965587 SESN3 0.48 6.05 0.32 3.9e-9 Migraine - clinic-based;Migraine with aura; CRC cis rs17376456 0.877 rs10066791 chr5:93350255 G/T cg25358565 chr5:93447407 FAM172A 1.11 10.67 0.51 5.15e-23 Diabetic retinopathy; CRC cis rs8072100 0.782 rs62074054 chr17:45771816 T/C cg08085267 chr17:45401833 C17orf57 -0.44 -6.43 -0.33 4.61e-10 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs3106136 0.527 rs2632411 chr4:95149434 G/A cg11021082 chr4:95130006 SMARCAD1 -0.57 -9.02 -0.45 1.54e-17 Capecitabine sensitivity; CRC cis rs9648716 0.935 rs6957490 chr7:140560307 C/T cg10747023 chr7:140774559 NA 0.45 5.82 0.31 1.42e-8 Type 2 diabetes; CRC cis rs57590327 0.503 rs17019299 chr3:81851643 A/G cg07356753 chr3:81810745 GBE1 -0.6 -8.26 -0.41 3.6e-15 Extraversion; CRC trans rs2727020 0.729 rs34647977 chr11:49195543 G/A cg21153622 chr11:89784906 NA -0.44 -7.15 -0.37 5.71e-12 Coronary artery disease; CRC cis rs704795 0.902 rs11887784 chr2:27679919 A/G cg24768116 chr2:27665128 KRTCAP3 -0.35 -7.74 -0.39 1.26e-13 Menopause (age at onset); CRC cis rs951366 0.789 rs823095 chr1:205679239 G/A cg14159672 chr1:205819179 PM20D1 0.71 10.12 0.49 3.84e-21 Menarche (age at onset); CRC cis rs7640424 0.620 rs7637244 chr3:107815763 T/A cg09227934 chr3:107805635 CD47 -0.49 -6.26 -0.33 1.22e-9 Body mass index; CRC cis rs875971 0.862 rs9791712 chr7:66105163 C/G cg11764359 chr7:65958608 NA -0.59 -8.78 -0.44 8.99e-17 Aortic root size; CRC cis rs883565 0.740 rs9311203 chr3:39072079 T/C cg01426195 chr3:39028469 NA -0.52 -8.3 -0.42 2.64e-15 Handedness; CRC cis rs1448094 0.511 rs4492889 chr12:86146735 C/A cg00310523 chr12:86230176 RASSF9 -0.36 -5.92 -0.31 8.25e-9 Major depressive disorder; CRC cis rs9926296 0.585 rs4785595 chr16:89835521 C/T cg21285383 chr16:89894308 SPIRE2 -0.4 -6.9 -0.36 2.65e-11 Vitiligo; CRC cis rs3749237 0.576 rs3877784 chr3:49539417 C/T cg07636037 chr3:49044803 WDR6 0.55 8.01 0.4 2.07e-14 Resting heart rate; CRC cis rs1448094 0.842 rs7309725 chr12:86440612 T/C cg18827107 chr12:86230957 RASSF9 -0.36 -5.7 -0.3 2.68e-8 Major depressive disorder; CRC cis rs992157 0.764 rs10932774 chr2:219191569 A/G cg04880052 chr2:219191631 PNKD 0.44 6.76 0.35 6.14e-11 Colorectal cancer; CRC cis rs459571 0.959 rs456205 chr9:136911146 G/A cg13789015 chr9:136890014 NCRNA00094 0.44 5.78 0.3 1.74e-8 Platelet distribution width; CRC cis rs735539 1.000 rs6490604 chr13:21284828 A/G cg04906043 chr13:21280425 IL17D -0.48 -8.16 -0.41 7.37e-15 Dental caries; CRC cis rs651907 0.535 rs11711903 chr3:101500748 C/G cg11279151 chr3:101281821 RG9MTD1 -0.52 -6.96 -0.36 1.84e-11 Colorectal cancer; CRC cis rs9457247 0.588 rs35171809 chr6:167432766 A/G cg07741184 chr6:167504864 NA 0.35 6.27 0.33 1.13e-9 Crohn's disease; CRC cis rs2739330 0.734 rs2000467 chr22:24241533 C/T cg16132339 chr22:24313637 DDTL;DDT -0.56 -8.44 -0.42 9.89e-16 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs7772486 0.654 rs6906402 chr6:146089307 C/G cg13319975 chr6:146136371 FBXO30 0.49 7.16 0.37 5.24e-12 Lobe attachment (rater-scored or self-reported); CRC cis rs2842992 0.724 rs2273823 chr6:160211485 T/C cg11366901 chr6:160182831 ACAT2 0.73 10.92 0.52 6.54e-24 Age-related macular degeneration (geographic atrophy); CRC cis rs7647973 0.807 rs4955416 chr3:49108428 T/C cg07636037 chr3:49044803 WDR6 0.87 11.68 0.54 1.33e-26 Menarche (age at onset); CRC cis rs4481887 1.000 rs10888351 chr1:248451608 G/A cg13385794 chr1:248469461 NA 0.36 6.26 0.33 1.17e-9 Common traits (Other); CRC cis rs2730245 0.527 rs842695 chr7:158662182 G/A cg24397884 chr7:158709396 WDR60 0.9 10.82 0.51 1.58e-23 Height; CRC cis rs11098499 0.691 rs9996644 chr4:120238877 G/T cg09307838 chr4:120376055 NA 0.63 9.79 0.47 5.05e-20 Corneal astigmatism; CRC cis rs875971 0.862 rs4718377 chr7:66049678 C/T cg12463550 chr7:65579703 CRCP -0.48 -6.44 -0.33 4.22e-10 Aortic root size; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg09392819 chr2:26568944 SELI;GPR113 0.39 6.47 0.34 3.54e-10 Liver disease severity in Alagille syndrome; CRC cis rs6540556 0.769 rs17389198 chr1:209922058 G/A cg23920097 chr1:209922102 NA -0.5 -5.68 -0.3 2.9e-8 Red blood cell count; CRC cis rs9372498 0.536 rs1319988 chr6:118782379 G/A cg18833306 chr6:118973337 C6orf204 0.45 5.82 0.31 1.44e-8 Diastolic blood pressure; CRC cis rs1656402 1.000 rs1729252 chr2:233428582 A/G cg03852847 chr2:233439513 NA -0.43 -7.57 -0.39 3.83e-13 Non-small cell lung cancer (survival); CRC cis rs9814567 0.752 rs4955542 chr3:134328740 A/G cg06109529 chr3:134205091 CEP63;ANAPC13 -0.67 -9.64 -0.47 1.56e-19 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg20824237 chr3:99979579 TBC1D23 0.42 6.03 0.32 4.46e-9 Intelligence (multi-trait analysis); CRC cis rs11628318 0.614 rs7155489 chr14:103123119 C/T cg12046867 chr14:103022105 NA 0.72 8.12 0.41 9.31e-15 Platelet count; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg17445839 chr17:79859999 NPB 0.41 7.55 0.38 4.37e-13 Liver disease severity in Alagille syndrome; CRC cis rs1799949 0.894 rs8176160 chr17:41241503 T/C cg05368731 chr17:41323189 NBR1 0.69 10.36 0.5 5.83e-22 Menopause (age at onset); CRC cis rs4713118 0.869 rs6914924 chr6:27711530 C/T cg21251018 chr6:28226885 NKAPL 0.38 5.71 0.3 2.5e-8 Parkinson's disease; CRC cis rs12926788 0.689 rs34365165 chr16:24856208 G/A cg06028605 chr16:24865363 SLC5A11 0.45 6.68 0.35 1.03e-10 Ejection fraction in Tripanosoma cruzi seropositivity; CRC trans rs916888 0.697 rs199516 chr17:44856485 C/T cg10053473 chr17:62856997 LRRC37A3 0.71 8.4 0.42 1.4e-15 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs780096 0.526 rs780117 chr2:27698343 C/G cg12648201 chr2:27665141 KRTCAP3 -0.31 -6.28 -0.33 1.05e-9 Total body bone mineral density; CRC trans rs13201294 1 rs13201294 chr6:27556141 A/T cg06606381 chr12:133084897 FBRSL1 -0.86 -6.47 -0.34 3.54e-10 Squamous cell lung carcinoma; CRC trans rs11764590 0.585 rs11772463 chr7:2078132 A/C cg11693508 chr17:37793320 STARD3 0.62 7.06 0.36 1.02e-11 Neuroticism; CRC cis rs9649213 0.593 rs6967576 chr7:98016373 A/G cg24562669 chr7:97807699 LMTK2 -0.4 -6.56 -0.34 2.06e-10 Prostate cancer (SNP x SNP interaction); CRC cis rs7811142 1.000 rs28490152 chr7:100020982 G/A cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.89 12.27 0.56 9.47e-29 Platelet count; CRC cis rs897984 0.683 rs72799316 chr16:30827205 A/G cg02466173 chr16:30829666 NA -0.86 -15.93 -0.66 9.21e-43 Dementia with Lewy bodies; CRC cis rs2730260 0.537 rs73169239 chr7:158884305 C/A cg02254261 chr7:158964346 NA -0.54 -6.19 -0.32 1.8e-9 Myopia (pathological); CRC cis rs6951245 1.000 rs28379681 chr7:1070539 C/T cg04025307 chr7:1156635 C7orf50 0.63 6.63 0.34 1.41e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs10504229 0.683 rs16921843 chr8:58113338 T/C cg02725872 chr8:58115012 NA -0.65 -11.61 -0.54 2.34e-26 Developmental language disorder (linguistic errors); CRC cis rs2836633 1.000 rs2836634 chr21:40068230 T/A cg05519781 chr21:40033154 ERG 0.57 10.42 0.5 3.78e-22 Coronary artery disease; CRC cis rs3617 0.573 rs6795646 chr3:52922621 C/T cg15147215 chr3:52552868 STAB1 0.43 7.09 0.36 8.02e-12 Red blood cell count;Autism spectrum disorder or schizophrenia; CRC cis rs1046896 0.739 rs2379358 chr17:80741612 G/A cg02711726 chr17:80685570 FN3KRP -0.57 -7.94 -0.4 3.12e-14 Glycated hemoglobin levels; CRC cis rs10512697 0.655 rs62338651 chr5:3472166 C/A cg19473799 chr5:3511975 NA -0.83 -6.35 -0.33 7.32e-10 Immune response to smallpox vaccine (IL-6); CRC trans rs5756813 0.754 rs8136757 chr22:38185971 A/G cg19894588 chr14:64061835 NA -0.57 -7.87 -0.4 5.07e-14 Optic cup area;Vertical cup-disc ratio; CRC cis rs909002 1.000 rs909002 chr1:32139635 C/T cg01639898 chr1:32083012 HCRTR1 0.28 5.7 0.3 2.69e-8 Intelligence (multi-trait analysis); CRC cis rs919433 0.714 rs2333855 chr2:198200213 T/G cg03934865 chr2:198174659 NA -0.4 -6.4 -0.33 5.33e-10 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC cis rs7527798 0.592 rs1323722 chr1:207823405 C/T cg21110645 chr1:207815933 NA -0.41 -6.36 -0.33 6.69e-10 Erythrocyte sedimentation rate; CRC cis rs9443645 0.901 rs1960542 chr6:79566643 C/T cg05283184 chr6:79620031 NA -0.57 -9.17 -0.45 5.26e-18 Intelligence (multi-trait analysis); CRC cis rs9818758 0.505 rs67286839 chr3:49265744 C/T cg00383909 chr3:49044727 WDR6 1.14 11.02 0.52 3.12e-24 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; CRC cis rs11212617 0.967 rs664982 chr11:108225483 C/T cg12106634 chr11:108092400 ATM;NPAT 0.44 6.56 0.34 2.03e-10 Response to metformin in type 2 diabetes (glycemic); CRC cis rs7769051 0.615 rs12209144 chr6:133191064 A/T cg22852734 chr6:133119734 C6orf192 0.94 10.62 0.51 7.26e-23 Type 2 diabetes nephropathy; CRC cis rs7103648 0.695 rs6485758 chr11:47530024 G/A cg20307385 chr11:47447363 PSMC3 0.85 12.61 0.57 5.31e-30 Diastolic blood pressure;Systolic blood pressure; CRC cis rs2456568 0.802 rs1506656 chr11:93639813 G/A cg26875233 chr11:93583750 C11orf90 -0.32 -6.18 -0.32 1.88e-9 Response to serotonin reuptake inhibitors in major depressive disorder; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg21955686 chr17:6555093 C17orf100;MED31 0.38 6.01 0.31 4.83e-9 Intelligence (multi-trait analysis); CRC cis rs7089973 0.966 rs12772800 chr10:116630962 A/G cg23260525 chr10:116636907 FAM160B1 0.32 6.41 0.33 4.98e-10 Bipolar disorder or attention deficit hyperactivity disorder; CRC cis rs10504229 0.683 rs7463453 chr8:58112053 A/G cg21724239 chr8:58056113 NA 0.5 6.89 0.35 2.89e-11 Developmental language disorder (linguistic errors); CRC cis rs2836974 0.965 rs6517538 chr21:40656242 C/T cg17971929 chr21:40555470 PSMG1 0.83 11.88 0.55 2.57e-27 Cognitive function; CRC cis rs9368481 0.761 rs9357030 chr6:26985026 G/T cg18867708 chr6:26865862 GUSBL1 -0.41 -5.71 -0.3 2.59e-8 Autism spectrum disorder or schizophrenia; CRC cis rs1129187 0.967 rs9462857 chr6:42943098 T/C cg02353165 chr6:42928485 GNMT 0.84 15.4 0.65 1.17e-40 Alzheimer's disease in APOE e4+ carriers; CRC cis rs9916302 0.904 rs4239222 chr17:37696235 A/C cg00129232 chr17:37814104 STARD3 0.52 7.83 0.4 6.76e-14 Glomerular filtration rate (creatinine); CRC cis rs748404 0.697 rs546170 chr15:43564849 T/C cg02155558 chr15:43621948 ADAL;LCMT2 0.44 6.58 0.34 1.9e-10 Lung cancer; CRC cis rs9457247 0.663 rs1894603 chr6:167434686 C/T cg07741184 chr6:167504864 NA -0.35 -6.31 -0.33 9.17e-10 Crohn's disease; CRC cis rs2408955 0.522 rs973398 chr12:48491048 A/G cg21466736 chr12:48725269 NA 0.46 7.12 0.37 6.99e-12 Glycated hemoglobin levels; CRC cis rs9303401 0.659 rs34468504 chr17:56648277 C/T cg02118635 chr17:56770003 RAD51C;TEX14 0.78 9.77 0.47 5.98e-20 Cognitive test performance; CRC cis rs71403859 0.502 rs35394108 chr16:71540639 T/C cg08717414 chr16:71523259 ZNF19 -0.98 -10.15 -0.49 3.16e-21 Post bronchodilator FEV1; CRC cis rs7809950 0.678 rs17154040 chr7:107005246 C/T cg23024343 chr7:107201750 COG5 0.69 9.57 0.47 2.67e-19 Coronary artery disease; CRC cis rs4727027 0.704 rs7787753 chr7:148901779 A/T cg23583168 chr7:148888333 NA -0.93 -17.93 -0.7 1.28e-50 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC cis rs3772130 0.564 rs28760466 chr3:121601510 A/G cg20356878 chr3:121714668 ILDR1 0.57 10.82 0.51 1.54e-23 Cognitive performance; CRC cis rs2204008 0.837 rs1589395 chr12:38420405 C/T cg13010199 chr12:38710504 ALG10B 0.47 6.32 0.33 8.32e-10 Bladder cancer; CRC cis rs6502050 0.835 rs4789751 chr17:80092373 G/T cg13198984 chr17:80129470 CCDC57 0.47 8.37 0.42 1.73e-15 Life satisfaction; CRC cis rs9341808 0.667 rs7746917 chr6:80931503 T/C cg08355045 chr6:80787529 NA 0.33 5.75 0.3 2.02e-8 Sitting height ratio; CRC cis rs8078723 1.000 rs3826331 chr17:38150492 T/C cg17344932 chr17:38183730 MED24;SNORD124 0.46 7.11 0.36 7.24e-12 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); CRC cis rs2979489 0.891 rs4733495 chr8:30366883 A/G cg26383811 chr8:30366931 RBPMS 0.81 12.86 0.58 6.31e-31 Mean corpuscular hemoglobin;Plateletcrit;Neutrophil count;Granulocyte count;Sum basophil neutrophil counts;Mean corpuscular volume;Myeloid white cell count;Sum neutrophil eosinophil counts; CRC cis rs11155671 0.530 rs6933882 chr6:150210802 A/G cg07701084 chr6:150067640 NUP43 0.49 7.2 0.37 4.04e-12 Testicular germ cell tumor; CRC cis rs62458065 0.640 rs10274556 chr7:32513947 A/G cg20159608 chr7:32802032 NA -0.59 -6.9 -0.36 2.61e-11 Metabolite levels (HVA/MHPG ratio); CRC cis rs4566357 0.595 rs2272203 chr2:227914655 C/G cg11843606 chr2:227700838 RHBDD1 -0.42 -6.58 -0.34 1.91e-10 Coronary artery disease; CRC cis rs17666538 0.710 rs7834337 chr8:655828 A/G cg07234876 chr8:600039 NA 0.8 7.97 0.4 2.66e-14 IgG glycosylation; CRC cis rs8180040 0.966 rs62260711 chr3:47564491 G/C cg27129171 chr3:47204927 SETD2 -0.62 -9.57 -0.47 2.57e-19 Colorectal cancer; CRC cis rs7584330 0.628 rs7591065 chr2:238390739 G/T cg16989719 chr2:238392110 NA -0.45 -7.01 -0.36 1.37e-11 Prostate cancer; CRC cis rs654950 0.743 rs115951861 chr1:41992488 C/T cg06885757 chr1:42089581 HIVEP3 -0.35 -6.01 -0.31 4.85e-9 Airway imaging phenotypes; CRC cis rs262150 0.851 rs2730249 chr7:158767628 A/G cg19418458 chr7:158789849 NA 0.44 7.5 0.38 5.93e-13 Facial morphology (factor 20); CRC cis rs2204008 0.811 rs12368410 chr12:38305705 C/T cg26384229 chr12:38710491 ALG10B 0.68 9.13 0.45 7.08e-18 Bladder cancer; CRC cis rs1552244 0.882 rs17050699 chr3:10037167 G/A cg08888203 chr3:10149979 C3orf24 0.62 8.3 0.42 2.65e-15 Alzheimer's disease; CRC cis rs58688157 0.880 rs12272314 chr11:590648 A/G cg03909863 chr11:638404 DRD4 -0.44 -6.26 -0.33 1.17e-9 Systemic lupus erythematosus; CRC cis rs6582630 0.555 rs7969922 chr12:38529491 C/T cg26384229 chr12:38710491 ALG10B 0.72 10.18 0.49 2.5e-21 Drug-induced liver injury (flucloxacillin); CRC cis rs9649213 0.555 rs6955259 chr7:97892356 T/A cg00277769 chr7:97922759 BAIAP2L1 -0.6 -10.35 -0.5 6.61e-22 Prostate cancer (SNP x SNP interaction); CRC cis rs9916302 0.851 rs11078906 chr17:37662767 C/T cg00129232 chr17:37814104 STARD3 -0.55 -8.11 -0.41 9.98e-15 Glomerular filtration rate (creatinine); CRC cis rs8141529 0.764 rs5762824 chr22:29222930 C/T cg02153584 chr22:29168773 CCDC117 0.52 7.75 0.39 1.17e-13 Lymphocyte counts; CRC cis rs727563 0.594 rs132807 chr22:42071584 T/C cg03806693 chr22:41940476 POLR3H 1.05 13.07 0.58 1.02e-31 Crohn's disease;Inflammatory bowel disease; CRC cis rs10504229 0.683 rs2088217 chr8:58113124 C/T cg02725872 chr8:58115012 NA -0.66 -11.64 -0.54 1.83e-26 Developmental language disorder (linguistic errors); CRC cis rs4363385 0.597 rs6679201 chr1:152976840 C/A cg25856811 chr1:152973957 SPRR3 -0.25 -6.76 -0.35 6.27e-11 Inflammatory skin disease; CRC cis rs1218582 0.651 rs4845396 chr1:154828409 A/G cg09359103 chr1:154839909 KCNN3 0.54 8.16 0.41 7.43e-15 Prostate cancer; CRC cis rs7937682 0.883 rs1789358 chr11:111474116 G/A cg09085632 chr11:111637200 PPP2R1B -0.97 -18.58 -0.72 3.48e-53 Primary sclerosing cholangitis; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg02758870 chr4:100871523 LOC256880;H2AFZ 0.39 6.36 0.33 6.72e-10 Liver disease severity in Alagille syndrome; CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg24991452 chr6:35996059 MAPK14 -0.49 -5.97 -0.31 6.16e-9 Diisocyanate-induced asthma; CRC cis rs2072499 0.778 rs41265025 chr1:156163906 C/T cg25208724 chr1:156163844 SLC25A44 1.01 16.3 0.67 3.35e-44 Testicular germ cell tumor; CRC cis rs12142240 0.667 rs12062 chr1:46830447 G/T cg14993813 chr1:46806288 NSUN4 0.51 6.64 0.34 1.3e-10 Menopause (age at onset); CRC cis rs1448094 0.512 rs11117060 chr12:86250788 G/T cg02569458 chr12:86230093 RASSF9 -0.42 -7.24 -0.37 3.19e-12 Major depressive disorder; CRC cis rs7412746 0.611 rs10888395 chr1:150762171 C/T cg18016565 chr1:150552671 MCL1 0.43 5.95 0.31 6.7e-9 Melanoma; CRC cis rs853679 0.517 rs55747925 chr6:28044337 T/C cg15845792 chr6:28175446 NA 0.97 13.03 0.58 1.43e-31 Depression; CRC cis rs6496667 0.600 rs28674812 chr15:91077809 G/T cg04176472 chr15:90893244 GABARAPL3 0.49 7.49 0.38 6.43e-13 Rheumatoid arthritis; CRC cis rs877282 0.891 rs12357999 chr10:796468 A/C cg17470449 chr10:769945 NA 0.68 9.03 0.45 1.48e-17 Uric acid levels; CRC cis rs995000 0.931 rs597078 chr1:62917857 G/A cg19896129 chr1:63156450 NA 0.44 6.73 0.35 7.45e-11 Triglyceride levels; CRC cis rs9296092 0.560 rs9469505 chr6:33527348 A/G cg13560919 chr6:33536144 NA -0.44 -6.28 -0.33 1.09e-9 Age at smoking initiation in chronic obstructive pulmonary disease; CRC cis rs4713118 0.513 rs149944 chr6:28002818 C/T cg15845792 chr6:28175446 NA 0.73 10.86 0.51 1.09e-23 Parkinson's disease; CRC cis rs6951245 1.000 rs113575110 chr7:1084394 G/A cg08132940 chr7:1081526 C7orf50 -0.54 -5.67 -0.3 3.04e-8 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs7615952 0.932 rs13321217 chr3:125631771 G/A cg05084668 chr3:125655381 ALG1L -0.5 -7.0 -0.36 1.41e-11 Blood pressure (smoking interaction); CRC cis rs8103278 1.000 rs36091860 chr19:46312880 G/A cg11657440 chr19:46296263 DMWD -0.5 -7.09 -0.36 8.46e-12 Coronary artery disease; CRC cis rs1048238 0.935 rs761760 chr1:16342419 A/G cg22431228 chr1:16359049 CLCNKA -0.38 -6.91 -0.36 2.52e-11 Systolic blood pressure; CRC cis rs7584330 0.740 rs2292885 chr2:238443407 G/C cg16989719 chr2:238392110 NA -0.39 -7.94 -0.4 3.23e-14 Prostate cancer; CRC cis rs2204008 0.748 rs8186658 chr12:38301461 A/C cg26384229 chr12:38710491 ALG10B 0.67 9.93 0.48 1.74e-20 Bladder cancer; CRC cis rs9910055 0.529 rs190144 chr17:42164584 A/G cg09913183 chr17:42254507 C17orf65;ASB16 -0.48 -6.41 -0.33 4.95e-10 Total body bone mineral density; CRC cis rs6860806 0.507 rs270601 chr5:131656997 T/C cg27615366 chr5:131592974 PDLIM4 0.34 5.86 0.31 1.1e-8 Breast cancer; CRC cis rs9470366 0.545 rs6930083 chr6:36634156 A/G cg08179530 chr6:36648295 CDKN1A -0.54 -7.88 -0.4 4.93e-14 QRS duration; CRC cis rs4638749 0.677 rs10185270 chr2:108838692 A/C cg25838818 chr2:108905173 SULT1C2 -0.34 -5.72 -0.3 2.33e-8 Blood pressure; CRC cis rs4750440 0.702 rs4750444 chr10:14029068 C/T cg00551146 chr10:14014579 FRMD4A 0.38 6.1 0.32 3e-9 Adiponectin levels; CRC cis rs8060686 0.925 rs13336189 chr16:67814152 C/A cg07125278 chr16:67683757 RLTPR -0.46 -5.98 -0.31 5.85e-9 HDL cholesterol;Metabolic syndrome; CRC cis rs1448094 0.648 rs10863093 chr12:86285792 T/G cg02569458 chr12:86230093 RASSF9 0.39 6.44 0.33 4.32e-10 Major depressive disorder; CRC cis rs9527 0.571 rs12219246 chr10:104613355 A/G cg04362960 chr10:104952993 NT5C2 0.57 7.98 0.4 2.51e-14 Arsenic metabolism; CRC cis rs7591163 1.000 rs1721359 chr2:228751874 C/T cg08034379 chr2:228736324 WDR69 -0.53 -7.16 -0.37 5.22e-12 Blood pressure; CRC cis rs7086803 0.557 rs7088796 chr10:114486621 G/A cg03281572 chr10:114502318 VTI1A 0.63 5.6 0.3 4.46e-8 Lung cancer; CRC cis rs10540 1.000 rs12794284 chr11:477623 C/T cg03352830 chr11:487213 PTDSS2 0.67 7.76 0.39 1.07e-13 Body mass index; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg27172057 chr12:64616385 C12orf66 0.48 6.7 0.35 9.2e-11 Response to antipsychotic treatment; CRC cis rs951366 0.903 rs823114 chr1:205719532 G/A cg17178900 chr1:205818956 PM20D1 0.44 6.58 0.34 1.88e-10 Menarche (age at onset); CRC cis rs2976388 0.578 rs34956412 chr8:143822028 C/T cg12516270 chr8:143859308 LYNX1 -0.39 -6.15 -0.32 2.24e-9 Urinary tract infection frequency; CRC cis rs4731207 1.000 rs4731207 chr7:124396645 G/A cg23710748 chr7:124431027 NA 0.4 6.44 0.33 4.19e-10 Cutaneous malignant melanoma; CRC trans rs9858542 0.903 rs9875617 chr3:49634696 G/A cg21665057 chr3:196295764 WDR53;FBXO45 -0.71 -9.59 -0.47 2.21e-19 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg15752043 chr10:120789955 NANOS1 0.46 6.61 0.34 1.53e-10 Response to antipsychotic treatment; CRC cis rs8114671 0.562 rs2273683 chr20:33509523 C/T cg07148914 chr20:33460835 GGT7 0.46 7.28 0.37 2.55e-12 Height; CRC cis rs9287719 0.967 rs12464908 chr2:10761496 T/G cg00105475 chr2:10696890 NA 0.45 7.27 0.37 2.63e-12 Prostate cancer; CRC cis rs13191362 1.000 rs13202339 chr6:163081812 G/A cg06582575 chr6:163149167 PACRG;PARK2 0.93 11.84 0.55 3.47e-27 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs734999 0.588 rs2843403 chr1:2529097 T/C cg18854424 chr1:2615690 NA -0.5 -9.85 -0.48 3.03e-20 Ulcerative colitis; CRC cis rs2730245 0.636 rs2657382 chr7:158650941 G/A cg24397884 chr7:158709396 WDR60 0.72 10.24 0.49 1.47e-21 Height; CRC cis rs7666738 0.830 rs6831925 chr4:98947401 T/C cg05340658 chr4:99064831 C4orf37 0.6 9.48 0.46 5.37e-19 Colonoscopy-negative controls vs population controls; CRC cis rs17092148 0.887 rs6059916 chr20:33148861 T/G cg08999081 chr20:33150536 PIGU 0.51 6.6 0.34 1.66e-10 Neuroticism; CRC cis rs17376456 0.825 rs10476590 chr5:93244884 A/T cg21475434 chr5:93447410 FAM172A 0.8 7.79 0.39 8.84e-14 Diabetic retinopathy; CRC cis rs796364 0.806 rs203766 chr2:200902672 T/C cg23649088 chr2:200775458 C2orf69 -0.63 -6.26 -0.33 1.22e-9 Schizophrenia; CRC trans rs2303319 0.504 rs62189048 chr2:162613494 G/C cg09481857 chr22:21368659 P2RX6;MGC16703 -0.65 -6.31 -0.33 9.13e-10 Cognitive function; CRC cis rs877282 0.898 rs11253341 chr10:765008 G/C cg17470449 chr10:769945 NA 0.66 8.48 0.42 7.57e-16 Uric acid levels; CRC cis rs7927592 0.913 rs3758643 chr11:68367193 C/T cg16797656 chr11:68205561 LRP5 0.38 6.05 0.32 3.99e-9 Total body bone mineral density; CRC cis rs2179367 0.959 rs544947 chr6:149723548 A/G cg07828024 chr6:149772892 ZC3H12D -0.37 -5.89 -0.31 9.7e-9 Dupuytren's disease; CRC cis rs9921222 1.000 rs9921222 chr16:375782 A/G cg00101154 chr16:420108 MRPL28 0.52 7.57 0.38 3.91e-13 Bone mineral density (spine);Bone mineral density; CRC cis rs11148252 0.716 rs1887360 chr13:52779166 A/G cg00495681 chr13:53174319 NA 0.56 7.99 0.4 2.35e-14 Lewy body disease; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg26002955 chr11:6255951 FAM160A2 0.38 6.29 0.33 1e-9 Liver disease severity in Alagille syndrome; CRC cis rs11098499 0.954 rs11940028 chr4:120411907 T/C cg24375607 chr4:120327624 NA 0.49 7.5 0.38 6.06e-13 Corneal astigmatism; CRC cis rs10782582 0.593 rs6664254 chr1:76235084 G/T cg05598546 chr1:76251766 SNORD45C;RABGGTB 0.46 5.93 0.31 7.48e-9 Daytime sleep phenotypes; CRC cis rs2404602 0.647 rs7181506 chr15:76935677 G/T cg03037974 chr15:76606532 NA 0.46 6.42 0.33 4.78e-10 Blood metabolite levels; CRC cis rs10540 0.841 rs35601764 chr11:532923 A/C cg03934478 chr11:495069 RNH1 0.67 7.36 0.38 1.45e-12 Body mass index; CRC cis rs13108904 0.934 rs13125338 chr4:1278435 A/C cg02018176 chr4:1364513 KIAA1530 0.48 7.93 0.4 3.43e-14 Obesity-related traits; CRC cis rs936229 0.668 rs67411922 chr15:75187612 A/G cg10253484 chr15:75165896 SCAMP2 -0.47 -6.95 -0.36 1.91e-11 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); CRC trans rs9858542 0.953 rs6803222 chr3:49665976 T/G cg21665057 chr3:196295764 WDR53;FBXO45 -0.69 -8.95 -0.44 2.61e-17 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs9291683 0.609 rs13141233 chr4:10028729 T/C cg00071950 chr4:10020882 SLC2A9 0.68 12.89 0.58 4.79e-31 Bone mineral density; CRC cis rs4805272 0.512 rs11879141 chr19:29320335 G/A cg12667521 chr19:29218732 NA 0.46 6.44 0.33 4.26e-10 Plasma omega-3 polyunsaturated fatty acid levels (docosahexaenoic acid); CRC cis rs644799 0.562 rs515546 chr11:95588756 G/C cg03916912 chr11:95522834 CEP57;FAM76B 0.68 11.2 0.53 7.17e-25 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs3733346 0.553 rs6813110 chr4:942660 C/T cg20814179 chr4:940893 TMEM175 0.57 11.04 0.52 2.55e-24 Sjögren's syndrome; CRC cis rs9322193 0.923 rs10782311 chr6:149943728 A/G cg07701084 chr6:150067640 NUP43 0.53 7.87 0.4 5.09e-14 Lung cancer; CRC cis rs6570726 1.000 rs405622 chr6:145871897 G/T cg23711669 chr6:146136114 FBXO30 0.72 12.47 0.57 1.66e-29 Lobe attachment (rater-scored or self-reported); CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg01814139 chr3:49840136 C3orf54 -0.4 -6.09 -0.32 3.12e-9 Myopia (pathological); CRC cis rs9910055 0.718 rs2526022 chr17:42213216 C/T cg13607699 chr17:42295918 UBTF 0.49 6.77 0.35 5.99e-11 Total body bone mineral density; CRC cis rs12745968 0.589 rs722356 chr1:92982405 G/A cg17283838 chr1:93427260 FAM69A -0.44 -6.02 -0.32 4.63e-9 Bipolar disorder and schizophrenia; CRC trans rs1681630 0.848 rs1631174 chr11:47974373 A/C cg15704280 chr7:45808275 SEPT13 -0.45 -6.02 -0.31 4.73e-9 Height; CRC cis rs7927771 1.000 rs35902101 chr11:47795169 C/T cg20307385 chr11:47447363 PSMC3 -0.5 -6.58 -0.34 1.83e-10 Subjective well-being; CRC cis rs34375054 0.526 rs117431213 chr12:125675271 C/G cg05341575 chr12:125625032 AACS -0.39 -5.99 -0.31 5.61e-9 Post bronchodilator FEV1/FVC ratio; CRC cis rs12936587 0.601 rs7212538 chr17:17554587 T/G cg24612305 chr17:17875800 TOM1L2;LRRC48 -0.38 -5.73 -0.3 2.24e-8 Hip circumference;Coronary artery disease or large artery stroke;Coronary heart disease;Coronary artery disease; CRC cis rs11628318 0.525 rs10129838 chr14:103154317 T/C cg23071808 chr14:103021642 NA 0.54 6.16 0.32 2.1e-9 Platelet count; CRC trans rs6703335 0.870 rs10803142 chr1:243598234 A/G cg11407514 chr10:99094219 FRAT2 0.44 6.19 0.32 1.78e-9 Schizophrenia;Schizophrenia, schizoaffective disorder or bipolar disorder; CRC cis rs1799949 1.000 rs1399323 chr17:41332330 T/C cg23758822 chr17:41437982 NA 0.79 13.57 0.6 1.3e-33 Menopause (age at onset); CRC cis rs965469 0.842 rs6051776 chr20:3332062 T/C cg25506879 chr20:3388711 C20orf194 -0.38 -5.88 -0.31 1.03e-8 IFN-related cytopenia; CRC cis rs1129187 0.967 rs6941212 chr6:42915920 A/G cg10862848 chr6:42927986 GNMT -0.36 -8.48 -0.42 7.5e-16 Alzheimer's disease in APOE e4+ carriers; CRC cis rs1348850 0.668 rs6734426 chr2:178493770 C/T cg27490568 chr2:178487706 NA 0.44 6.04 0.32 4.09e-9 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs4268898 0.679 rs2551181 chr2:24437548 C/T cg06627628 chr2:24431161 ITSN2 0.65 8.9 0.44 3.81e-17 Asthma; CRC cis rs35110281 0.720 rs162375 chr21:44927015 C/T cg01579765 chr21:45077557 HSF2BP 0.34 6.44 0.33 4.13e-10 Mean corpuscular volume; CRC trans rs561341 1.000 rs535151 chr17:30317405 C/T cg20587970 chr11:113659929 NA -0.98 -14.41 -0.62 7.74e-37 Hip circumference adjusted for BMI; CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg16221875 chr6:21588597 NA -0.51 -6.39 -0.33 5.62e-10 Diisocyanate-induced asthma; CRC cis rs7487075 1.000 rs12813763 chr12:46822904 G/T cg22049899 chr12:47219821 SLC38A4 -0.31 -6.04 -0.32 4.14e-9 Itch intensity from mosquito bite; CRC cis rs427943 0.695 rs8128889 chr21:46615331 T/C cg19498844 chr21:46707878 POFUT2;LOC642852 0.44 5.97 0.31 6.09e-9 Body mass index; CRC cis rs875971 0.638 rs6960778 chr7:66071597 C/T cg00343986 chr7:65444356 GUSB -0.49 -7.3 -0.37 2.16e-12 Aortic root size; CRC cis rs4665630 0.522 rs2712054 chr2:23956123 C/T cg08063864 chr2:24346004 PFN4;LOC375190 0.52 5.63 0.3 3.96e-8 Hypertension; CRC cis rs9914988 0.943 rs7224870 chr17:27102620 A/G cg12682573 chr17:27188876 MIR451;MIR144 0.62 9.37 0.46 1.16e-18 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs736408 0.812 rs2240920 chr3:52831009 A/G cg11645453 chr3:52864694 ITIH4 -0.36 -6.09 -0.32 3.21e-9 Bipolar disorder; CRC trans rs9929218 1.000 rs12446407 chr16:68804068 G/A cg04657470 chr2:198365150 HSPE1;HSPD1 -0.84 -11.93 -0.55 1.64e-27 Colorectal cancer; CRC cis rs524281 0.731 rs476551 chr11:66006323 G/C cg14036092 chr11:66035641 RAB1B -0.58 -6.71 -0.35 8.61e-11 Electroencephalogram traits; CRC cis rs9527 0.590 rs11191544 chr10:104827198 C/G cg15744005 chr10:104629667 AS3MT -0.3 -5.92 -0.31 8.04e-9 Arsenic metabolism; CRC cis rs1941023 0.503 rs894591 chr11:60132647 T/C cg08716584 chr11:60157161 MS4A7 -0.53 -9.02 -0.45 1.54e-17 Congenital heart disease (maternal effect); CRC cis rs7429990 1.000 rs319680 chr3:47898307 A/G cg11946769 chr3:48343235 NME6 0.46 5.8 0.3 1.55e-8 Educational attainment (years of education); CRC cis rs10504229 0.609 rs56289889 chr8:58116276 G/C cg04204079 chr8:58130323 NA -0.45 -5.78 -0.3 1.71e-8 Developmental language disorder (linguistic errors); CRC cis rs2281845 0.965 rs7516023 chr1:201085521 C/T cg08885800 chr1:201084119 NA 0.49 8.93 0.44 2.97e-17 Permanent tooth development; CRC cis rs875971 0.862 rs1167408 chr7:65556108 G/A cg18876405 chr7:65276391 NA -0.51 -8.49 -0.42 6.96e-16 Aortic root size; CRC cis rs67478160 0.619 rs12886363 chr14:104273786 T/C cg08213375 chr14:104286397 PPP1R13B 0.62 12.41 0.56 2.91e-29 Schizophrenia; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg25635316 chr7:23637023 CCDC126 0.49 6.5 0.34 2.95e-10 Thyroid stimulating hormone; CRC cis rs6502050 0.835 rs12938965 chr17:80128646 G/A cg02741985 chr17:80059408 CCDC57 0.44 7.24 0.37 3.25e-12 Life satisfaction; CRC cis rs4481887 0.962 rs10788768 chr1:248456027 G/A cg00666640 chr1:248458726 OR2T12 0.53 9.43 0.46 7.58e-19 Common traits (Other); CRC cis rs2228479 0.850 rs11647174 chr16:89958538 G/A cg12064134 chr16:90016061 DEF8 -0.69 -6.14 -0.32 2.38e-9 Skin colour saturation; CRC cis rs3818285 0.556 rs3758409 chr10:111669239 A/C cg00817464 chr10:111662876 XPNPEP1 -0.43 -5.69 -0.3 2.78e-8 Superior crus of antihelix expression; CRC cis rs17095355 1.000 rs75079039 chr10:111745121 T/C cg00817464 chr10:111662876 XPNPEP1 -0.59 -6.98 -0.36 1.59e-11 Biliary atresia; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg20261243 chr20:44718728 NCOA5 0.52 7.52 0.38 5.15e-13 Response to antipsychotic treatment; CRC cis rs1983891 1.000 rs4714483 chr6:41528214 G/A cg20194872 chr6:41519635 FOXP4 0.4 5.75 0.3 2.04e-8 Prostate cancer; CRC cis rs6502050 0.835 rs6502059 chr17:80082886 T/C cg22110888 chr17:80059540 CCDC57 -0.41 -6.39 -0.33 5.58e-10 Life satisfaction; CRC cis rs1881797 1.000 rs10925069 chr1:247681313 C/T cg18198730 chr1:247681584 NA -0.62 -10.93 -0.52 6.38e-24 Acute lymphoblastic leukemia (childhood); CRC cis rs35306767 0.903 rs1341741 chr10:888073 A/G cg26597838 chr10:835615 NA 0.88 10.85 0.51 1.2e-23 Eosinophil percentage of granulocytes; CRC cis rs7618501 0.815 rs3819325 chr3:49843723 T/C cg24308560 chr3:49941425 MST1R -0.46 -7.16 -0.37 5.19e-12 Intelligence (multi-trait analysis); CRC cis rs13256369 1.000 rs10103769 chr8:8573036 G/T cg00074818 chr8:8560427 CLDN23 0.4 7.28 0.37 2.44e-12 Obesity-related traits; CRC cis rs28386778 0.901 rs2854194 chr17:61952110 T/G cg25654072 chr17:61904446 PSMC5;FTSJ3 0.72 11.13 0.52 1.23e-24 Prudent dietary pattern; CRC cis rs7177699 0.557 rs4433781 chr15:79121835 A/T cg15571903 chr15:79123663 NA -0.31 -6.05 -0.32 3.86e-9 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; CRC cis rs2243480 0.808 rs12698508 chr7:65411958 A/T cg12463550 chr7:65579703 CRCP 0.66 6.19 0.32 1.79e-9 Diabetic kidney disease; CRC cis rs7264396 0.635 rs6121073 chr20:34457513 G/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.6 -9.96 -0.48 1.37e-20 Total cholesterol levels; CRC trans rs17685 0.753 rs2302438 chr7:75677065 C/A cg19862616 chr7:65841803 NCRNA00174 0.98 18.25 0.71 7e-52 Coffee consumption;Coffee consumption (cups per day); CRC trans rs9747201 1.000 rs12943668 chr17:80109930 C/T cg07393940 chr7:158741817 NA -0.52 -7.43 -0.38 9.26e-13 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs7236492 0.627 rs76032846 chr18:77198322 G/A cg15644404 chr18:77186268 NFATC1 -0.56 -5.78 -0.3 1.75e-8 Inflammatory bowel disease;Crohn's disease; CRC trans rs17301013 0.606 rs11487399 chr1:174496267 C/T cg15203214 chr6:379489 NA 0.38 5.97 0.31 6.01e-9 Systemic lupus erythematosus; CRC cis rs2839186 1.000 rs2839186 chr21:47690068 C/T cg11766577 chr21:47581405 C21orf56 -0.39 -5.83 -0.31 1.32e-8 Testicular germ cell tumor; CRC cis rs7727544 0.625 rs3091338 chr5:131402738 C/T cg12564285 chr5:131593104 PDLIM4 0.36 5.95 0.31 6.84e-9 Blood metabolite levels; CRC cis rs806795 0.605 rs809871 chr6:26256526 C/G cg13736514 chr6:26305472 NA 0.52 8.71 0.43 1.47e-16 Mosquito bite size; CRC cis rs9469578 0.792 rs73743329 chr6:33713943 T/A cg18708504 chr6:33715942 IP6K3 0.66 7.56 0.38 4e-13 Phosphorus levels; CRC cis rs7680126 0.632 rs78030862 chr4:10150412 G/A cg00071950 chr4:10020882 SLC2A9 -0.48 -6.15 -0.32 2.29e-9 Urate levels in lean individuals;Urate levels in overweight individuals;Urate levels in obese individuals; CRC cis rs9611565 0.592 rs5996039 chr22:41981957 A/G cg03806693 chr22:41940476 POLR3H -0.74 -9.51 -0.46 4.03e-19 Vitiligo; CRC cis rs9322193 0.923 rs7740278 chr6:149961252 C/T cg00933542 chr6:150070202 PCMT1 0.29 6.08 0.32 3.37e-9 Lung cancer; CRC cis rs17095355 1.000 rs12254785 chr10:111699607 C/T cg00817464 chr10:111662876 XPNPEP1 -0.62 -8.38 -0.42 1.58e-15 Biliary atresia; CRC cis rs9354308 0.899 rs1938059 chr6:66539291 G/A cg07460842 chr6:66804631 NA 0.46 5.7 0.3 2.64e-8 Metabolite levels; CRC cis rs3741404 0.620 rs882147 chr11:63976689 T/A cg19465662 chr11:63993652 NUDT22;TRPT1 0.74 11.86 0.55 2.95e-27 Platelet count; CRC cis rs3736485 0.934 rs4143724 chr15:51870413 T/A cg08986416 chr15:51914746 DMXL2 -0.46 -6.63 -0.34 1.41e-10 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs10751667 0.643 rs10751671 chr11:944479 T/G cg23136738 chr11:925521 AP2A2 -0.42 -6.98 -0.36 1.65e-11 Alzheimer's disease (late onset); CRC trans rs1005277 0.579 rs2749616 chr10:38510993 A/T cg23533926 chr12:111358616 MYL2 -0.55 -8.38 -0.42 1.6e-15 Extrinsic epigenetic age acceleration; CRC cis rs853679 0.513 rs9468296 chr6:28113730 A/G cg03623178 chr6:28175578 NA 0.98 12.66 0.57 3.31e-30 Depression; CRC cis rs7605827 0.897 rs10166429 chr2:15514472 A/C cg19274914 chr2:15703543 NA 0.38 5.78 0.3 1.78e-8 Educational attainment (years of education); CRC cis rs826838 1.000 rs1095575 chr12:39110284 C/G cg26384229 chr12:38710491 ALG10B -0.61 -9.48 -0.46 5.08e-19 Heart rate; CRC cis rs1799949 1.000 rs8176202 chr17:41230228 G/A cg19454999 chr17:41278357 BRCA1;NBR2 0.54 8.25 0.41 3.86e-15 Menopause (age at onset); CRC cis rs77633900 0.614 rs2468116 chr15:76870998 G/A cg21673338 chr15:77095150 SCAPER -0.76 -8.02 -0.4 1.86e-14 Non-glioblastoma glioma;Glioma; CRC cis rs832540 0.898 rs252890 chr5:56226410 T/C cg20203395 chr5:56204925 C5orf35 -0.41 -5.82 -0.31 1.38e-8 Coronary artery disease; CRC cis rs7739232 0.920 rs79431838 chr6:53526721 G/A cg15658676 chr6:53530538 KLHL31 -0.76 -5.9 -0.31 8.9e-9 Hip circumference adjusted for BMI; CRC cis rs9916302 0.808 rs12943928 chr17:37611330 G/A cg00129232 chr17:37814104 STARD3 -0.55 -8.17 -0.41 6.79e-15 Glomerular filtration rate (creatinine); CRC cis rs9326248 0.906 rs171052 chr11:117081763 C/G cg15534755 chr11:117069859 TAGLN -0.35 -6.56 -0.34 2.05e-10 Blood protein levels; CRC cis rs11098499 0.954 rs17009122 chr4:120362403 G/A cg09307838 chr4:120376055 NA 0.72 11.14 0.52 1.1e-24 Corneal astigmatism; CRC cis rs62103177 0.810 rs3902996 chr18:77630571 A/G cg12964065 chr18:77638022 KCNG2 0.66 6.69 0.35 9.56e-11 Opioid sensitivity; CRC cis rs7517126 1.000 rs7514704 chr1:196839991 A/G cg13682187 chr1:196946512 CFHR5 -0.37 -6.04 -0.32 4.2e-9 Blood protein levels; CRC cis rs5758511 0.773 rs73165164 chr22:42355549 T/C cg00645731 chr22:42541494 CYP2D7P1 0.47 6.99 0.36 1.57e-11 Birth weight; CRC cis rs2836974 0.568 rs8130795 chr21:40549983 T/A cg17971929 chr21:40555470 PSMG1 0.69 10.35 0.5 6.24e-22 Cognitive function; CRC cis rs2836974 0.674 rs1011413 chr21:40638241 A/G cg22974920 chr21:40686053 BRWD1 -0.42 -5.81 -0.31 1.47e-8 Cognitive function; CRC cis rs10875943 0.751 rs11168962 chr12:49672739 A/T cg17570948 chr12:49726661 C1QL4 -0.37 -6.25 -0.33 1.28e-9 Prostate cancer; CRC cis rs11650494 0.710 rs8065814 chr17:47470720 T/C cg08112188 chr17:47440006 ZNF652 0.67 5.99 0.31 5.63e-9 Prostate cancer; CRC cis rs6860806 0.507 rs156322 chr5:131653925 C/T cg07395648 chr5:131743802 NA -0.44 -6.04 -0.32 4.12e-9 Breast cancer; CRC cis rs7666738 0.791 rs2865958 chr4:99040732 G/T cg05340658 chr4:99064831 C4orf37 0.6 9.45 0.46 6.36e-19 Colonoscopy-negative controls vs population controls; CRC cis rs6598955 0.670 rs4659366 chr1:26542572 G/A cg00852783 chr1:26633632 UBXN11 0.46 7.38 0.38 1.34e-12 Obesity-related traits; CRC cis rs12681288 0.823 rs2701907 chr8:1003292 A/G cg08648136 chr8:956695 NA 0.29 5.61 0.3 4.3e-8 Schizophrenia; CRC cis rs2120019 0.938 rs8040169 chr15:75370958 C/A cg11632617 chr15:75315747 PPCDC -0.56 -7.96 -0.4 2.86e-14 Blood trace element (Zn levels); CRC cis rs12410462 0.581 rs35141785 chr1:227553496 G/C cg23173402 chr1:227635558 NA 0.58 5.61 0.3 4.21e-8 Major depressive disorder; CRC cis rs10991814 0.920 rs10512210 chr9:94048529 A/G cg14446406 chr9:93919335 NA -0.55 -6.31 -0.33 9.14e-10 Neutrophil percentage of granulocytes; CRC cis rs730775 0.505 rs324137 chr6:44273546 G/T cg21130236 chr6:44246755 TMEM151B 0.45 7.36 0.38 1.49e-12 Monocyte percentage of white cells;Monocyte count; CRC cis rs9399137 0.507 rs4896118 chr6:135276065 A/G cg24558204 chr6:135376177 HBS1L -0.61 -8.97 -0.44 2.37e-17 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; CRC cis rs4555082 0.794 rs2735827 chr14:105710600 T/A cg18132624 chr14:105716052 BTBD6;BRF1 -0.49 -8.05 -0.41 1.56e-14 Mean platelet volume;Platelet distribution width; CRC cis rs1008375 0.966 rs6449329 chr4:17703677 T/C cg16339924 chr4:17578868 LAP3 0.49 6.3 0.33 9.78e-10 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs9660992 0.626 rs61823972 chr1:205201325 A/C cg21643547 chr1:205240462 TMCC2 -0.37 -6.11 -0.32 2.85e-9 Mean corpuscular volume;Mean platelet volume; CRC cis rs7119 0.651 rs34607443 chr15:77847892 C/T cg27398640 chr15:77910606 LINGO1 -0.41 -6.83 -0.35 4.04e-11 Type 2 diabetes; CRC cis rs2032447 0.966 rs7756117 chr6:26046565 A/G cg12588279 chr6:26043732 HIST1H2BB -0.43 -6.43 -0.33 4.51e-10 Intelligence (multi-trait analysis); CRC cis rs9399135 0.967 rs6923827 chr6:135335382 C/T cg22676075 chr6:135203613 NA 0.4 6.12 0.32 2.65e-9 Red blood cell count; CRC cis rs8044868 0.530 rs2241411 chr16:72144493 T/C cg06172871 chr16:72088244 HP 0.43 6.25 0.33 1.27e-9 Body mass index (change over time) in cancer or chronic obstructive pulmonary disease;Body mass index (change over time) in cancer; CRC trans rs12478296 0.685 rs67829386 chr2:242992276 T/A cg18288967 chr1:45987694 PRDX1 0.68 7.23 0.37 3.33e-12 Obesity-related traits; CRC cis rs10504229 0.683 rs72650847 chr8:58136825 C/T cg08219700 chr8:58056026 NA 0.55 6.46 0.34 3.69e-10 Developmental language disorder (linguistic errors); CRC cis rs9368481 0.594 rs7768643 chr6:26891919 C/T cg12292205 chr6:26970375 C6orf41 0.63 9.98 0.48 1.12e-20 Autism spectrum disorder or schizophrenia; CRC cis rs155076 1.000 rs261423 chr13:21852331 A/C cg21970626 chr13:21893289 NA 0.46 6.0 0.31 5.12e-9 White matter hyperintensity burden; CRC cis rs2303759 0.709 rs2278405 chr19:49812403 A/C cg22590775 chr19:49891494 CCDC155 -0.59 -7.73 -0.39 1.29e-13 Multiple sclerosis; CRC cis rs11608355 0.618 rs2075435 chr12:109796832 C/T cg19025524 chr12:109796872 NA -0.65 -10.93 -0.52 6.03e-24 Neuroticism; CRC trans rs1814175 0.588 rs10839463 chr11:49971643 A/G cg15704280 chr7:45808275 SEPT13 -0.94 -16.94 -0.68 1.01e-46 Height; CRC cis rs7618915 0.571 rs67539070 chr3:52711974 T/C cg07507251 chr3:52567010 NT5DC2 0.42 6.06 0.32 3.7e-9 Bipolar disorder; CRC cis rs7666738 0.606 rs28481322 chr4:99086638 T/C cg05340658 chr4:99064831 C4orf37 0.49 7.21 0.37 3.95e-12 Colonoscopy-negative controls vs population controls; CRC cis rs1799949 0.965 rs11654051 chr17:41419656 C/T cg01879757 chr17:41196368 BRCA1 -0.41 -6.05 -0.32 4.03e-9 Menopause (age at onset); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg03840924 chr17:47645509 NA 0.4 5.98 0.31 5.94e-9 Intelligence (multi-trait analysis); CRC trans rs16984718 1.000 rs16984718 chr2:18509254 C/T cg03909902 chr12:108154529 PRDM4 0.55 6.1 0.32 3.05e-9 Urate levels in obese individuals; CRC cis rs10504229 0.728 rs17804365 chr8:58151537 C/A cg08219700 chr8:58056026 NA 0.45 5.74 0.3 2.11e-8 Developmental language disorder (linguistic errors); CRC cis rs11098499 0.863 rs1010739 chr4:120463471 C/T cg09307838 chr4:120376055 NA 0.68 10.38 0.5 5.16e-22 Corneal astigmatism; CRC trans rs4308415 0.753 rs1390071 chr4:67802231 G/A cg19648955 chr2:177134095 MTX2 -0.41 -5.99 -0.31 5.44e-9 Educational attainment (years of education); CRC cis rs11098499 0.909 rs35165976 chr4:120325630 G/A cg24375607 chr4:120327624 NA 0.51 7.91 0.4 3.87e-14 Corneal astigmatism; CRC cis rs950027 0.787 rs1153845 chr15:45724729 C/T cg21132104 chr15:45694354 SPATA5L1 -0.4 -5.76 -0.3 1.97e-8 Response to fenofibrate (adiponectin levels); CRC cis rs1707322 0.721 rs61784796 chr1:46163256 A/G cg06784218 chr1:46089804 CCDC17 0.66 12.38 0.56 3.81e-29 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs7149337 0.836 rs11622116 chr14:51670744 C/T cg23942311 chr14:51606299 NA 0.74 13.6 0.6 1.01e-33 Cancer; CRC cis rs6088580 0.634 rs6088483 chr20:32984714 T/A cg08999081 chr20:33150536 PIGU -0.62 -11.69 -0.54 1.22e-26 Glomerular filtration rate (creatinine); CRC cis rs34172651 0.917 rs11074651 chr16:24778409 A/G cg00339695 chr16:24857497 SLC5A11 0.28 6.86 0.35 3.39e-11 Intelligence (multi-trait analysis); CRC cis rs4604732 0.642 rs7515859 chr1:247640057 A/G cg02104434 chr1:247694406 LOC148824;OR2C3 0.42 6.69 0.35 9.39e-11 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CRC cis rs7727544 0.716 rs2089855 chr5:131573529 A/G cg11843238 chr5:131593191 PDLIM4 0.35 6.45 0.33 4.08e-10 Blood metabolite levels; CRC cis rs10504229 0.683 rs2318148 chr8:58114955 G/A cg22535103 chr8:58192502 C8orf71 -0.69 -9.28 -0.46 2.38e-18 Developmental language disorder (linguistic errors); CRC trans rs1455244 0.700 rs7229302 chr18:11508904 G/T ch.1.1254747R chr1:39934760 MACF1 0.42 6.07 0.32 3.43e-9 Schizophrenia; CRC cis rs34172651 0.917 rs200538 chr16:24735736 C/T cg06505273 chr16:24850292 NA -0.37 -5.67 -0.3 3.17e-8 Intelligence (multi-trait analysis); CRC cis rs1865760 0.593 rs3903852 chr6:25915147 G/T cg12310025 chr6:25882481 NA -0.47 -7.18 -0.37 4.77e-12 Height; CRC cis rs8078723 1.000 rs7214085 chr17:38169095 T/C cg17344932 chr17:38183730 MED24;SNORD124 -0.45 -7.01 -0.36 1.37e-11 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); CRC cis rs9325144 0.602 rs10785590 chr12:38694145 C/T cg13010199 chr12:38710504 ALG10B 0.44 6.31 0.33 8.89e-10 Morning vs. evening chronotype; CRC cis rs1707322 1.000 rs10890370 chr1:46389217 C/T cg03146154 chr1:46216737 IPP 0.49 6.67 0.35 1.1e-10 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs853679 0.550 rs34477097 chr6:28197186 C/T cg06470822 chr6:28175283 NA 0.88 12.01 0.55 8.51e-28 Depression; CRC cis rs875971 0.862 rs1612452 chr7:65573896 T/A cg11764359 chr7:65958608 NA -0.59 -9.3 -0.46 2.02e-18 Aortic root size; CRC cis rs6456156 0.742 rs3093026 chr6:167532690 A/G cg07513332 chr6:167530253 CCR6 0.38 6.9 0.36 2.6e-11 Primary biliary cholangitis; CRC cis rs425277 0.606 rs2503705 chr1:2076741 A/G cg21194808 chr1:2205498 SKI 0.39 6.08 0.32 3.31e-9 Height; CRC cis rs6964587 1.000 rs2961020 chr7:91573308 G/A cg17063962 chr7:91808500 NA -0.75 -12.32 -0.56 6.13e-29 Breast cancer; CRC cis rs6952808 0.895 rs4513875 chr7:1928159 C/T cg02951883 chr7:2050386 MAD1L1 -0.73 -11.97 -0.55 1.15e-27 Bipolar disorder and schizophrenia; CRC cis rs6835098 1.000 rs4695826 chr4:174089426 T/G cg08422745 chr4:174089978 GALNT7 -0.98 -16.67 -0.68 1.12e-45 Dementia and core Alzheimer's disease neuropathologic changes; CRC cis rs3768617 0.565 rs4233194 chr1:183060917 G/C ch.1.3577855R chr1:183094577 LAMC1 0.84 14.4 0.62 8.78e-37 Fuchs's corneal dystrophy; CRC cis rs2235649 0.663 rs6600168 chr16:1848927 C/T cg00935504 chr16:1863053 HAGH 0.31 5.62 0.3 4.07e-8 Blood metabolite levels; CRC cis rs4713118 0.669 rs200997 chr6:27811815 G/A cg12273811 chr6:28175739 NA 0.48 6.73 0.35 7.39e-11 Parkinson's disease; CRC cis rs6860806 0.507 rs2631371 chr5:131703691 G/A cg24060327 chr5:131705240 SLC22A5 0.54 8.12 0.41 9.4e-15 Breast cancer; CRC cis rs2274273 0.600 rs10131730 chr14:55840092 C/T cg10130446 chr14:55658398 DLGAP5 -0.43 -6.13 -0.32 2.46e-9 Protein biomarker; CRC trans rs1814175 0.702 rs4881644 chr11:49786367 C/T cg03929089 chr4:120376271 NA -0.94 -17.77 -0.7 5.11e-50 Height; CRC cis rs67311347 1.000 rs73080137 chr3:40516412 A/G cg24209194 chr3:40518798 ZNF619 0.4 5.82 0.31 1.4e-8 Renal cell carcinoma; CRC cis rs4713118 0.539 rs200967 chr6:27862127 A/G cg03623178 chr6:28175578 NA 0.75 10.6 0.5 9.08e-23 Parkinson's disease; CRC cis rs2996428 0.667 rs61768933 chr1:3766587 G/A cg17848003 chr1:3704513 LRRC47 0.4 5.92 0.31 8.3e-9 Red cell distribution width; CRC cis rs765787 0.530 rs11639403 chr15:45538350 A/G cg24006582 chr15:45444508 DUOX1 -0.57 -8.63 -0.43 2.62e-16 Uric acid levels; CRC trans rs7615952 0.512 rs4646765 chr3:125820707 G/A cg07211511 chr3:129823064 LOC729375 -0.69 -9.08 -0.45 1.02e-17 Blood pressure (smoking interaction); CRC trans rs1814175 0.616 rs1794131 chr11:49904194 A/G cg03929089 chr4:120376271 NA -0.92 -16.06 -0.66 3.01e-43 Height; CRC cis rs11190604 1.000 rs2489039 chr10:102328036 T/A cg16342193 chr10:102329863 NA -0.34 -5.81 -0.3 1.51e-8 Palmitoleic acid (16:1n-7) levels; CRC cis rs60871478 1.000 rs62432251 chr7:801855 T/G cg13844804 chr7:814759 HEATR2 0.68 8.66 0.43 2.2e-16 Cerebrospinal P-tau181p levels; CRC cis rs6534441 0.727 rs58293561 chr4:125440801 C/T cg21609808 chr4:125404261 NA 0.39 5.63 0.3 3.77e-8 Major depressive disorder; CRC cis rs3020333 0.875 rs3020336 chr6:152013760 G/T cg22157087 chr6:152012887 ESR1 0.53 7.87 0.4 5.16e-14 Total body bone mineral density; CRC cis rs2404602 0.647 rs116090606 chr15:77075209 A/G cg23625390 chr15:77176239 SCAPER -0.85 -13.87 -0.61 8.95e-35 Blood metabolite levels; CRC cis rs28374715 0.532 rs11070328 chr15:41651569 T/C cg18705301 chr15:41695430 NDUFAF1 -1.12 -19.7 -0.74 1.29e-57 Ulcerative colitis; CRC cis rs1005277 0.579 rs176880 chr10:38401417 C/G cg25427524 chr10:38739819 LOC399744 0.77 13.6 0.6 1e-33 Extrinsic epigenetic age acceleration; CRC cis rs28386778 0.897 rs2665831 chr17:61912392 C/T cg06873352 chr17:61820015 STRADA 0.81 15.43 0.65 8.96e-41 Prudent dietary pattern; CRC cis rs58688157 0.705 rs12421646 chr11:578844 C/G cg09218773 chr11:619014 MUPCDH -0.42 -6.04 -0.32 4.13e-9 Systemic lupus erythematosus; CRC cis rs4285028 0.948 rs73855481 chr3:121676951 C/A cg11130432 chr3:121712080 ILDR1 -0.52 -6.75 -0.35 6.81e-11 Multiple sclerosis; CRC cis rs938554 0.744 rs7675964 chr4:9941434 C/T cg00071950 chr4:10020882 SLC2A9 -0.44 -6.77 -0.35 5.97e-11 Blood metabolite levels; CRC cis rs477692 0.544 rs12251589 chr10:131417354 C/A cg05714579 chr10:131428358 MGMT -0.9 -14.16 -0.62 7.02e-36 Response to temozolomide; CRC cis rs875971 0.862 rs6460279 chr7:65662761 T/C cg00343986 chr7:65444356 GUSB -0.47 -6.52 -0.34 2.69e-10 Aortic root size; CRC trans rs2303319 0.504 rs58622044 chr2:162596287 A/G cg05865860 chr7:158649142 WDR60 -0.71 -5.97 -0.31 6.26e-9 Cognitive function; CRC cis rs802075 1.000 rs360560 chr6:49659634 C/A cg20364632 chr6:49636226 NA -0.36 -5.87 -0.31 1.05e-8 Bone mineral density (hip) and age at menarche; CRC cis rs651907 0.557 rs13081846 chr3:101383321 T/C cg11279151 chr3:101281821 RG9MTD1 -0.57 -7.74 -0.39 1.25e-13 Colorectal cancer; CRC cis rs9303280 0.806 rs4795395 chr17:37962987 T/A cg17344932 chr17:38183730 MED24;SNORD124 0.34 5.64 0.3 3.76e-8 Self-reported allergy; CRC cis rs7149337 1.000 rs4261445 chr14:51723540 G/A cg18282456 chr14:51561492 TRIM9 0.28 5.61 0.3 4.35e-8 Cancer; CRC cis rs1448094 0.511 rs4559760 chr12:86149414 G/A cg19622623 chr12:86230825 RASSF9 0.4 6.15 0.32 2.22e-9 Major depressive disorder; CRC cis rs9733 0.519 rs7511673 chr1:150707636 A/T cg10589385 chr1:150898437 SETDB1 0.29 6.13 0.32 2.47e-9 Tonsillectomy; CRC cis rs6951245 1.000 rs1997243 chr7:1083777 A/G cg08132940 chr7:1081526 C7orf50 -0.54 -5.64 -0.3 3.65e-8 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs7147624 0.572 rs72714498 chr14:66037734 C/T cg03016385 chr14:66212404 NA 1.05 8.32 0.42 2.38e-15 Chronic obstructive pulmonary disease-related biomarkers; CRC trans rs1814175 0.781 rs2866734 chr11:49886338 A/G cg03929089 chr4:120376271 NA -0.97 -19.07 -0.72 3.93e-55 Height; CRC cis rs6908034 0.660 rs7746588 chr6:19804640 C/T cg02682789 chr6:19804855 NA 0.79 7.64 0.39 2.36e-13 Endometriosis;Deep ovarian and/or rectovaginal disease with dense adhesions; CRC cis rs9322193 0.504 rs7771014 chr6:150205446 T/A cg13206674 chr6:150067644 NUP43 0.44 6.2 0.32 1.71e-9 Lung cancer; CRC cis rs1552172 0.887 rs34695381 chr1:145683334 G/C cg11743829 chr1:145714124 CD160 -0.43 -6.36 -0.33 6.74e-10 Breast cancer; CRC cis rs1949733 0.523 rs16842563 chr4:8545146 C/T cg11789530 chr4:8429930 ACOX3 -0.57 -7.8 -0.4 8.03e-14 Response to antineoplastic agents; CRC cis rs7772486 0.719 rs702317 chr6:146005010 C/T cg23711669 chr6:146136114 FBXO30 -0.75 -12.72 -0.57 1.97e-30 Lobe attachment (rater-scored or self-reported); CRC cis rs8141529 0.702 rs469990 chr22:29304200 A/T cg02153584 chr22:29168773 CCDC117 0.45 6.61 0.34 1.54e-10 Lymphocyte counts; CRC cis rs1320333 0.772 rs2867116 chr2:682363 C/A cg20966539 chr2:681320 NA 0.65 6.11 0.32 2.76e-9 Obesity-related traits; CRC cis rs780096 0.526 rs75855890 chr2:27625005 G/T cg17158414 chr2:27665306 KRTCAP3 -0.29 -6.05 -0.32 4.03e-9 Total body bone mineral density; CRC cis rs7726839 0.540 rs72705030 chr5:645562 C/T cg16447950 chr5:562315 NA -0.78 -10.26 -0.49 1.35e-21 Obesity-related traits; CRC cis rs758324 0.947 rs2896961 chr5:131165006 C/T cg06307176 chr5:131281290 NA 0.42 6.52 0.34 2.67e-10 Alzheimer's disease in APOE e4- carriers; CRC cis rs6570726 0.720 rs412623 chr6:145883257 C/A cg13319975 chr6:146136371 FBXO30 -0.43 -6.43 -0.33 4.41e-10 Lobe attachment (rater-scored or self-reported); CRC cis rs4481887 1.000 rs10888358 chr1:248471467 C/A cg13385794 chr1:248469461 NA 0.36 6.34 0.33 7.63e-10 Common traits (Other); CRC cis rs3820068 0.705 rs4646085 chr1:15825411 A/T cg27534772 chr1:16042836 PLEKHM2 0.41 6.95 0.36 1.99e-11 Systolic blood pressure; CRC cis rs250677 0.687 rs10040624 chr5:148437579 A/G cg18129178 chr5:148520854 ABLIM3 -0.37 -5.7 -0.3 2.72e-8 Breast cancer; CRC cis rs12044355 0.896 rs11122324 chr1:231859181 C/T cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX 0.42 5.86 0.31 1.14e-8 Alzheimer's disease; CRC cis rs727505 0.954 rs59673207 chr7:124596982 G/C cg23710748 chr7:124431027 NA -0.81 -14.19 -0.62 5.26e-36 Lewy body disease; CRC cis rs9467711 0.538 rs7766531 chr6:25886577 T/C cg16898833 chr6:26189333 HIST1H4D 0.65 5.76 0.3 1.88e-8 Autism spectrum disorder or schizophrenia; CRC trans rs10504229 0.906 rs58251024 chr8:58172259 G/C cg04077850 chr5:125800366 GRAMD3 0.37 6.27 0.33 1.15e-9 Developmental language disorder (linguistic errors); CRC cis rs738322 0.511 rs2267370 chr22:38576826 G/A cg25457927 chr22:38595422 NA -0.31 -5.7 -0.3 2.69e-8 Cutaneous nevi; CRC cis rs17270561 0.609 rs4712965 chr6:25742022 G/T cg17691542 chr6:26056736 HIST1H1C 0.72 9.24 0.45 3.07e-18 Iron status biomarkers; CRC trans rs9951602 0.512 rs12607938 chr18:76651887 A/C cg02800362 chr5:177631904 HNRNPAB 0.61 9.27 0.46 2.59e-18 Obesity-related traits; CRC cis rs2730245 0.527 rs924910 chr7:158672272 C/T cg24397884 chr7:158709396 WDR60 0.93 11.25 0.53 4.78e-25 Height; CRC cis rs9875589 0.509 rs6770928 chr3:14077189 G/C cg14375111 chr3:14165186 TMEM43;CHCHD4 0.41 6.03 0.32 4.35e-9 Ovarian reserve; CRC cis rs595982 0.527 rs17272673 chr19:49362992 C/A cg21252483 chr19:49399788 TULP2 -0.36 -5.7 -0.3 2.7e-8 Red cell distribution width; CRC cis rs12541635 0.639 rs1032545 chr8:107005825 C/T cg10147462 chr8:107024639 NA 0.57 9.91 0.48 1.97e-20 Age of smoking initiation; CRC trans rs7395662 0.817 rs1848151 chr11:48692658 G/A cg21153622 chr11:89784906 NA -0.47 -7.68 -0.39 1.88e-13 HDL cholesterol; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg21426974 chr4:140005758 ELF2 0.37 6.21 0.32 1.59e-9 Liver disease severity in Alagille syndrome; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg14725858 chr5:36241190 C5orf33 0.42 6.24 0.33 1.37e-9 Response to antipsychotic treatment; CRC cis rs10504229 0.683 rs11774645 chr8:58132921 G/C cg02725872 chr8:58115012 NA -0.58 -8.39 -0.42 1.5e-15 Developmental language disorder (linguistic errors); CRC cis rs28386778 0.787 rs2665827 chr17:61961350 G/C cg06873352 chr17:61820015 STRADA 0.75 13.09 0.59 8.08e-32 Prudent dietary pattern; CRC cis rs2404602 0.735 rs2468130 chr15:76796496 T/C cg03037974 chr15:76606532 NA -0.41 -5.99 -0.31 5.44e-9 Blood metabolite levels; CRC cis rs10504229 1.000 rs57941207 chr8:58169821 A/G cg05313129 chr8:58192883 C8orf71 -0.46 -6.81 -0.35 4.6e-11 Developmental language disorder (linguistic errors); CRC cis rs9894429 0.572 rs112417725 chr17:79578219 A/G cg13777783 chr17:79615861 NA 0.3 5.73 0.3 2.28e-8 Eye color traits; CRC cis rs965469 0.843 rs6139122 chr20:3395871 T/G cg25506879 chr20:3388711 C20orf194 -0.4 -6.07 -0.32 3.43e-9 IFN-related cytopenia; CRC cis rs9916302 0.861 rs4795377 chr17:37669056 C/T cg07936489 chr17:37558343 FBXL20 -0.84 -13.25 -0.59 2.04e-32 Glomerular filtration rate (creatinine); CRC trans rs877282 0.583 rs10904566 chr10:821662 C/G cg22713356 chr15:30763199 NA 0.88 9.65 0.47 1.49e-19 Uric acid levels; CRC cis rs9649213 0.502 rs6465680 chr7:98005778 A/G cg21770322 chr7:97807741 LMTK2 0.53 8.66 0.43 2.11e-16 Prostate cancer (SNP x SNP interaction); CRC trans rs62103177 0.565 rs473119 chr18:77849459 T/G cg05926928 chr17:57297772 GDPD1 -0.58 -6.08 -0.32 3.28e-9 Opioid sensitivity; CRC cis rs1953600 0.870 rs2789690 chr10:81938204 G/T cg00277334 chr10:82204260 NA 0.37 5.93 0.31 7.57e-9 Sarcoidosis; CRC cis rs6032067 1.000 rs34885285 chr20:43804789 C/A cg10761708 chr20:43804764 PI3 0.5 5.8 0.3 1.54e-8 Blood protein levels; CRC cis rs77861329 1.000 rs9847092 chr3:52199453 T/C cg08692210 chr3:52188851 WDR51A 0.89 8.51 0.42 6.37e-16 Macrophage inflammatory protein 1b levels; CRC cis rs3749237 0.595 rs4855839 chr3:49507847 G/A cg07636037 chr3:49044803 WDR6 0.54 7.93 0.4 3.47e-14 Resting heart rate; CRC cis rs11166629 1.000 rs7818331 chr8:135639653 C/T cg27224718 chr8:135614730 ZFAT 0.49 7.28 0.37 2.52e-12 Smoking quantity; CRC cis rs6951245 0.935 rs61753396 chr7:1105372 A/G cg24642844 chr7:1081250 C7orf50 -0.77 -9.29 -0.46 2.23e-18 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs10752881 1.000 rs12126434 chr1:182988414 A/G ch.1.3577855R chr1:183094577 LAMC1 -0.83 -14.9 -0.63 9.63e-39 Colorectal cancer; CRC cis rs9611565 0.659 rs9607812 chr22:41941243 G/A cg03806693 chr22:41940476 POLR3H -1.13 -15.35 -0.65 1.7e-40 Vitiligo; CRC trans rs4263408 0.934 rs9683743 chr4:39703194 A/C cg05378032 chr9:131798819 FAM73B -0.42 -6.06 -0.32 3.64e-9 Plasma amyloid beta peptide concentrations (ABx-40); CRC cis rs2354432 0.556 rs885305 chr1:146786080 G/A cg25205988 chr1:146714368 CHD1L -1.14 -9.48 -0.46 5.05e-19 Mitochondrial DNA levels; CRC trans rs3733585 0.673 rs9993410 chr4:9951264 C/T cg26043149 chr18:55253948 FECH -0.47 -7.13 -0.37 6.39e-12 Cleft plate (environmental tobacco smoke interaction); CRC cis rs10504229 1.000 rs72650892 chr8:58179714 A/G cg01721255 chr8:58191610 C8orf71 0.49 6.17 0.32 2e-9 Developmental language disorder (linguistic errors); CRC cis rs12477438 0.765 rs12612688 chr2:99613091 C/G cg26064155 chr2:99771622 LIPT1;TSGA10 -0.6 -8.34 -0.42 2.08e-15 Chronic sinus infection; CRC cis rs9733 0.596 rs1136808 chr1:150702717 G/C cg10589385 chr1:150898437 SETDB1 0.28 5.96 0.31 6.66e-9 Tonsillectomy; CRC trans rs9747201 0.894 rs4503854 chr17:80178696 A/T cg07393940 chr7:158741817 NA 0.52 7.31 0.37 2e-12 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs9914988 0.943 rs59461345 chr17:27151852 G/T cg20469991 chr17:27169893 C17orf63 -0.59 -7.19 -0.37 4.48e-12 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs17376456 0.825 rs10058331 chr5:93279115 T/G cg21475434 chr5:93447410 FAM172A 0.83 7.88 0.4 4.83e-14 Diabetic retinopathy; CRC cis rs2721195 0.967 rs10108150 chr8:145687475 A/G cg17328964 chr8:145687451 CYHR1 0.68 11.73 0.54 9.01e-27 Age at first birth; CRC cis rs10504229 0.683 rs73605816 chr8:58117167 T/C cg22535103 chr8:58192502 C8orf71 -0.7 -9.34 -0.46 1.47e-18 Developmental language disorder (linguistic errors); CRC cis rs7208859 0.623 rs59447372 chr17:29057585 C/T cg01831904 chr17:28903510 LRRC37B2 -0.62 -6.27 -0.33 1.12e-9 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs3820068 0.677 rs72643691 chr1:15856251 T/C cg27534772 chr1:16042836 PLEKHM2 0.43 7.26 0.37 2.74e-12 Systolic blood pressure; CRC cis rs1003719 0.737 rs9974374 chr21:38479885 A/G cg10648535 chr21:38446584 PIGP;TTC3 0.52 7.42 0.38 1.03e-12 Eye color traits; CRC cis rs9322193 0.961 rs2064520 chr6:149924786 A/T cg05861140 chr6:150128134 PCMT1 -0.36 -5.87 -0.31 1.05e-8 Lung cancer; CRC cis rs7937682 0.632 rs11603779 chr11:111781047 A/C cg19812747 chr11:111475976 SIK2 0.43 6.2 0.32 1.65e-9 Primary sclerosing cholangitis; CRC cis rs9322193 0.923 rs10782311 chr6:149943728 A/G cg05861140 chr6:150128134 PCMT1 -0.36 -5.96 -0.31 6.46e-9 Lung cancer; CRC trans rs9858542 0.953 rs10640 chr3:49454277 G/A cg21582582 chr3:182698605 DCUN1D1 -0.52 -6.54 -0.34 2.3e-10 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC trans rs1728785 1.000 rs1170443 chr16:68573295 G/C cg04657470 chr2:198365150 HSPE1;HSPD1 0.56 6.67 0.35 1.1e-10 Ulcerative colitis; CRC cis rs59104589 0.521 rs56697150 chr2:242430085 C/A cg19488206 chr2:242435732 STK25 0.43 6.92 0.36 2.31e-11 Fibrinogen levels; CRC cis rs1008375 1.000 rs4698634 chr4:17630192 A/C cg04450456 chr4:17643702 FAM184B -0.38 -6.17 -0.32 2.05e-9 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs7849270 0.959 rs2094704 chr9:131918294 A/G cg13538475 chr9:131942899 NA -0.34 -6.34 -0.33 7.58e-10 Blood metabolite ratios; CRC cis rs35110281 0.591 rs86139 chr21:44932802 G/A cg01579765 chr21:45077557 HSF2BP -0.35 -6.56 -0.34 2.09e-10 Mean corpuscular volume; CRC cis rs1158570 0.500 rs7846376 chr8:131155443 G/A cg21674704 chr8:131455249 NA -0.41 -6.21 -0.32 1.58e-9 Platelet count; CRC cis rs3204270 0.714 rs8074828 chr17:79657136 G/C cg09655341 chr17:79618100 PDE6G 0.57 6.88 0.35 3.08e-11 Dental caries; CRC cis rs7772486 0.686 rs1004752 chr6:146037822 G/A cg13319975 chr6:146136371 FBXO30 0.43 6.45 0.34 3.96e-10 Lobe attachment (rater-scored or self-reported); CRC cis rs9522267 0.535 rs914037 chr13:112235308 A/G cg26182253 chr13:112236782 NA 0.31 6.33 0.33 7.97e-10 Hepatitis; CRC cis rs6582630 0.519 rs12819814 chr12:38332568 G/C cg26384229 chr12:38710491 ALG10B 0.67 9.48 0.46 5.14e-19 Drug-induced liver injury (flucloxacillin); CRC cis rs1355223 0.583 rs2915179 chr11:34871943 C/T cg24088639 chr11:34937564 PDHX;APIP -0.58 -8.52 -0.43 5.82e-16 Systemic lupus erythematosus and Systemic sclerosis; CRC cis rs1865760 0.865 rs9467650 chr6:25958235 A/G cg17691542 chr6:26056736 HIST1H1C 0.55 8.4 0.42 1.36e-15 Height; CRC cis rs7412746 0.658 rs7521719 chr1:150913134 G/A cg17724175 chr1:150552817 MCL1 0.44 6.72 0.35 8.22e-11 Melanoma; CRC cis rs2979489 0.841 rs2015311 chr8:30306989 A/G cg26383811 chr8:30366931 RBPMS 0.7 9.85 0.48 3.22e-20 Mean corpuscular hemoglobin;Plateletcrit;Neutrophil count;Granulocyte count;Sum basophil neutrophil counts;Mean corpuscular volume;Myeloid white cell count;Sum neutrophil eosinophil counts; CRC cis rs7527798 0.571 rs11118237 chr1:207818719 G/A cg09232269 chr1:207846808 CR1L -0.49 -7.69 -0.39 1.74e-13 Erythrocyte sedimentation rate; CRC cis rs7927592 0.913 rs2282563 chr11:68333200 C/T cg01657329 chr11:68192670 LRP5 -0.47 -6.7 -0.35 8.9e-11 Total body bone mineral density; CRC cis rs1150668 0.699 rs1531681 chr6:28226878 A/G cg15845792 chr6:28175446 NA 0.49 7.3 0.37 2.22e-12 Pubertal anthropometrics; CRC cis rs9818758 0.607 rs73074866 chr3:49626666 C/T cg07636037 chr3:49044803 WDR6 -0.8 -5.89 -0.31 9.69e-9 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; CRC cis rs6502050 0.799 rs7502533 chr17:80109778 A/G cg11859384 chr17:80120422 CCDC57 -0.37 -5.85 -0.31 1.16e-8 Life satisfaction; CRC cis rs7824557 0.564 rs2736290 chr8:11234298 C/T cg08071915 chr8:12219732 FAM66A 0.33 6.03 0.32 4.37e-9 Retinal vascular caliber; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg00473834 chr3:23987430 NR1D2 0.47 6.13 0.32 2.48e-9 Anxiety disorder; CRC cis rs9435341 1.000 rs9435341 chr1:107616641 T/C cg09367891 chr1:107599246 PRMT6 -0.63 -9.8 -0.48 4.66e-20 Facial morphology (factor 21, depth of nasal alae); CRC trans rs9858542 0.953 rs9827708 chr3:49649989 C/G cg21665057 chr3:196295764 WDR53;FBXO45 -0.7 -9.23 -0.45 3.38e-18 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs1552244 0.608 rs3732962 chr3:10048951 T/C cg02579736 chr3:10068473 FANCD2;CIDECP 0.68 9.51 0.46 4.18e-19 Alzheimer's disease; CRC cis rs6502050 0.835 rs9898697 chr17:80100498 A/G cg25804541 chr17:80189381 SLC16A3 -0.31 -6.08 -0.32 3.24e-9 Life satisfaction; CRC cis rs7224685 0.501 rs2727064 chr17:3934101 A/G cg21851534 chr17:3907994 ZZEF1 0.36 6.13 0.32 2.55e-9 Type 2 diabetes; CRC cis rs9487051 0.872 rs9487038 chr6:109610152 T/C cg01475377 chr6:109611718 NA -0.49 -9.26 -0.45 2.75e-18 Reticulocyte fraction of red cells; CRC cis rs7208859 0.573 rs55661352 chr17:29045628 A/G cg13385521 chr17:29058706 SUZ12P 0.7 7.86 0.4 5.61e-14 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs4988958 0.565 rs3771154 chr2:103039360 C/T cg03938978 chr2:103052716 IL18RAP 0.59 10.13 0.49 3.5e-21 Asthma (childhood onset); CRC cis rs1865721 0.804 rs72977818 chr18:73146852 T/C cg26385618 chr18:73139727 C18orf62 -0.4 -5.67 -0.3 3.15e-8 Intelligence; CRC cis rs4561483 0.831 rs8052900 chr16:11940390 T/C cg08843971 chr16:11963173 GSPT1 0.58 8.2 0.41 5.55e-15 Testicular germ cell tumor; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg00455178 chr11:14913981 CYP2R1 0.42 6.37 0.33 6.36e-10 Intelligence (multi-trait analysis); CRC cis rs738321 0.762 rs4820321 chr22:38579569 T/A cg25457927 chr22:38595422 NA -0.38 -7.17 -0.37 4.85e-12 Breast cancer; CRC cis rs950027 0.620 rs2453533 chr15:45641225 C/A cg21132104 chr15:45694354 SPATA5L1 0.42 6.21 0.32 1.61e-9 Response to fenofibrate (adiponectin levels); CRC cis rs35110281 0.626 rs162368 chr21:44934767 G/A cg04455712 chr21:45112962 RRP1B 0.38 7.13 0.37 6.49e-12 Mean corpuscular volume; CRC cis rs10751667 0.666 rs10902241 chr11:949129 G/A ch.11.42038R chr11:967971 AP2A2 0.57 9.77 0.47 5.76e-20 Alzheimer's disease (late onset); CRC cis rs2836950 0.501 rs4818018 chr21:40694072 C/T cg11890956 chr21:40555474 PSMG1 -0.61 -8.88 -0.44 4.4e-17 Menarche (age at onset); CRC cis rs754466 0.580 rs10762765 chr10:79566407 T/C cg17075019 chr10:79541650 NA -0.93 -17.27 -0.69 5.06e-48 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs4862750 0.837 rs1863404 chr4:187874654 T/C cg03452623 chr4:187889614 NA -0.89 -20.48 -0.75 1.13e-60 Lobe attachment (rater-scored or self-reported); CRC cis rs17253792 0.822 rs112418863 chr14:56114079 G/A cg01858014 chr14:56050164 KTN1 -0.87 -7.23 -0.37 3.31e-12 Putamen volume; CRC cis rs736408 0.812 rs746694 chr3:52826620 C/T cg08222913 chr3:52553049 STAB1 -0.32 -5.62 -0.3 4.04e-8 Bipolar disorder; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg04496233 chr11:64863659 C11orf2 0.5 7.05 0.36 1.05e-11 Response to antipsychotic treatment; CRC cis rs3733585 0.699 rs4276278 chr4:9948870 T/C cg00071950 chr4:10020882 SLC2A9 -0.54 -9.52 -0.46 4e-19 Cleft plate (environmental tobacco smoke interaction); CRC cis rs7647973 0.516 rs4955418 chr3:49200627 A/G cg03060546 chr3:49711283 APEH 0.4 5.66 0.3 3.33e-8 Menarche (age at onset); CRC cis rs1182436 1 rs1182436 chr7:157027753 T/C cg05182265 chr7:156933206 UBE3C 0.62 8.98 0.44 2.09e-17 Type 2 diabetes; CRC cis rs6860806 0.507 rs635620 chr5:131720263 A/G cg11843238 chr5:131593191 PDLIM4 -0.44 -7.39 -0.38 1.26e-12 Breast cancer; CRC cis rs394563 0.591 rs805026 chr6:149728254 G/C cg11245181 chr6:149772854 ZC3H12D -0.53 -9.29 -0.46 2.17e-18 Dupuytren's disease; CRC cis rs875971 1.000 rs778726 chr7:65828731 C/T cg11764359 chr7:65958608 NA 0.61 9.95 0.48 1.44e-20 Aortic root size; CRC cis rs1448094 0.510 rs11117016 chr12:86141602 T/C cg06740227 chr12:86229804 RASSF9 -0.37 -5.75 -0.3 2e-8 Major depressive disorder; CRC trans rs2303319 0.504 rs62189055 chr2:162625749 C/A cg21546874 chr1:9294571 H6PD -0.7 -6.03 -0.32 4.44e-9 Cognitive function; CRC cis rs10256972 0.630 rs13235747 chr7:1129123 T/C cg04025307 chr7:1156635 C7orf50 0.71 11.53 0.54 4.5e-26 Longevity;Endometriosis; CRC cis rs7835763 0.642 rs2468152 chr8:119106765 A/T cg11592677 chr8:119110466 EXT1 -0.39 -6.39 -0.33 5.66e-10 Autism spectrum disorder; CRC cis rs6088580 0.524 rs6088568 chr20:33265971 A/C cg08999081 chr20:33150536 PIGU -0.38 -5.69 -0.3 2.79e-8 Glomerular filtration rate (creatinine); CRC cis rs155076 1.000 rs261407 chr13:21855213 C/A cg21970626 chr13:21893289 NA 0.44 5.8 0.3 1.59e-8 White matter hyperintensity burden; CRC cis rs853679 0.585 rs201001 chr6:27808899 T/C cg06470822 chr6:28175283 NA 0.62 6.81 0.35 4.6e-11 Depression; CRC cis rs7178572 0.633 rs11857860 chr15:77839761 T/C cg22256960 chr15:77711686 NA -0.64 -9.26 -0.45 2.71e-18 Type 2 diabetes; CRC cis rs3018066 0.831 rs10003024 chr4:107074097 G/A cg01869342 chr4:106983673 TBCK 0.37 5.74 0.3 2.15e-8 Cancer; CRC cis rs4843747 0.671 rs8053377 chr16:88106465 A/G cg07865391 chr16:88106882 BANP 0.46 6.05 0.32 3.86e-9 Menopause (age at onset); CRC trans rs2018683 0.649 rs221171 chr7:29006139 C/G cg19402173 chr7:128379420 CALU 0.47 6.55 0.34 2.24e-10 Response to irinotecan and platinum-based chemotherapy in non-small-cell lung cancer; CRC cis rs9322193 0.923 rs3924871 chr6:149983216 G/A cg05861140 chr6:150128134 PCMT1 -0.36 -5.85 -0.31 1.18e-8 Lung cancer; CRC cis rs6089584 0.546 rs6061980 chr20:60618877 G/A cg23463467 chr20:60627584 TAF4 0.41 7.51 0.38 5.56e-13 Body mass index; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg06221470 chr7:2353869 SNX8 0.37 6.12 0.32 2.69e-9 Liver disease severity in Alagille syndrome; CRC cis rs1448094 0.645 rs12301701 chr12:86472798 C/T cg02569458 chr12:86230093 RASSF9 -0.42 -7.12 -0.37 6.98e-12 Major depressive disorder; CRC cis rs12142240 0.621 rs13374968 chr1:46843908 T/G cg00530320 chr1:46809349 NSUN4 0.6 8.14 0.41 8.41e-15 Menopause (age at onset); CRC cis rs2739330 0.760 rs1007888 chr22:24241101 C/T cg11060661 chr22:24314208 DDT;DDTL 0.46 7.92 0.4 3.76e-14 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs10791097 0.690 rs12284487 chr11:130729705 T/C cg12179176 chr11:130786555 SNX19 0.68 11.03 0.52 2.76e-24 Autism spectrum disorder or schizophrenia;Schizophrenia; CRC cis rs9361491 0.657 rs9448537 chr6:79437747 G/A cg05283184 chr6:79620031 NA -0.37 -5.69 -0.3 2.84e-8 Intelligence (multi-trait analysis); CRC cis rs7618915 0.501 rs2336146 chr3:52626646 A/G cg08222913 chr3:52553049 STAB1 -0.34 -6.35 -0.33 7.09e-10 Bipolar disorder; CRC cis rs7586879 0.559 rs13387729 chr2:25076126 A/G cg04586622 chr2:25135609 ADCY3 -0.48 -8.59 -0.43 3.64e-16 Body mass index; CRC cis rs9491140 0.539 rs11154228 chr6:124686042 A/G cg22366943 chr6:124882293 NKAIN2 0.56 8.4 0.42 1.39e-15 Neuroticism; CRC cis rs10504229 0.728 rs78765835 chr8:58154337 A/G cg21724239 chr8:58056113 NA 0.62 8.38 0.42 1.51e-15 Developmental language disorder (linguistic errors); CRC cis rs4713118 0.869 rs6930992 chr6:27712120 A/C cg26587870 chr6:27730563 NA -0.43 -6.72 -0.35 8.04e-11 Parkinson's disease; CRC cis rs3820068 0.581 rs72645888 chr1:15929922 C/A cg24675056 chr1:15929824 NA 0.49 6.77 0.35 5.87e-11 Systolic blood pressure; CRC cis rs10499694 0.967 rs11765748 chr7:50615616 T/A cg18232548 chr7:50535776 DDC -0.41 -6.28 -0.33 1.1e-9 Body mass index; CRC cis rs7937682 0.737 rs518294 chr11:111424716 A/T cg09085632 chr11:111637200 PPP2R1B -0.73 -12.07 -0.55 5.16e-28 Primary sclerosing cholangitis; CRC cis rs2243480 1.000 rs1701758 chr7:65470201 T/A cg18252515 chr7:66147081 NA -1.06 -12.27 -0.56 9.34e-29 Diabetic kidney disease; CRC cis rs847577 0.609 rs7791463 chr7:97819047 G/A cg24562669 chr7:97807699 LMTK2 0.79 17.64 0.7 1.69e-49 Breast cancer; CRC cis rs13256369 1.000 rs4841016 chr8:8572561 C/T cg17143192 chr8:8559678 CLDN23 0.46 5.94 0.31 7.35e-9 Obesity-related traits; CRC cis rs17711722 0.510 rs73142128 chr7:65331109 A/C cg05627663 chr7:65219948 SNORA22;CCT6P1 0.68 10.43 0.5 3.46e-22 Calcium levels; CRC cis rs8077889 0.871 rs16940243 chr17:41900003 C/G cg25876840 chr17:41920477 NA 0.5 7.61 0.39 2.87e-13 Triglycerides; CRC cis rs9322193 0.886 rs9718079 chr6:149967083 T/C cg00933542 chr6:150070202 PCMT1 0.3 5.99 0.31 5.57e-9 Lung cancer; CRC cis rs13118159 0.801 rs13147602 chr4:1332175 A/G cg20887711 chr4:1340912 KIAA1530 0.42 5.64 0.3 3.59e-8 Longevity; CRC cis rs9527 0.662 rs10786714 chr10:104598606 G/C cg15744005 chr10:104629667 AS3MT -0.36 -6.65 -0.34 1.25e-10 Arsenic metabolism; CRC cis rs9926296 0.712 rs447735 chr16:89734349 T/C cg01097406 chr16:89675127 NA 0.52 9.29 0.46 2.22e-18 Vitiligo; CRC cis rs9916302 0.800 rs11869259 chr17:37518141 C/A cg07936489 chr17:37558343 FBXL20 0.8 12.24 0.56 1.19e-28 Glomerular filtration rate (creatinine); CRC cis rs10540 1.000 rs12419716 chr11:503385 C/G cg03934478 chr11:495069 RNH1 0.69 7.77 0.39 9.92e-14 Body mass index; CRC cis rs2279817 0.955 rs2270978 chr1:18023365 C/T cg21791023 chr1:18019539 ARHGEF10L 0.47 5.98 0.31 5.87e-9 Neuroticism; CRC trans rs875971 0.660 rs2191268 chr7:66110224 C/T cg09755102 chr1:33283495 S100PBP;YARS -0.44 -6.76 -0.35 6.23e-11 Aortic root size; CRC cis rs10870270 1.000 rs72636963 chr10:133771271 C/T cg17892150 chr10:133769511 PPP2R2D -0.75 -11.0 -0.52 3.67e-24 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; CRC cis rs950169 0.959 rs66801143 chr15:84736657 C/T cg11189052 chr15:85197271 WDR73 0.61 8.81 0.44 7.07e-17 Schizophrenia; CRC cis rs13118159 0.573 rs4974618 chr4:1373663 C/T cg19318889 chr4:1322082 MAEA 0.67 9.89 0.48 2.35e-20 Longevity; CRC cis rs40363 0.645 rs1690449 chr16:3520893 C/G cg21433313 chr16:3507492 NAT15 0.55 8.07 0.41 1.31e-14 Tuberculosis; CRC cis rs6502050 0.835 rs8065556 chr17:80091176 G/C cg09264619 chr17:80180166 NA -0.36 -6.04 -0.32 4.23e-9 Life satisfaction; CRC cis rs6988636 0.710 rs62521805 chr8:124159200 C/T cg27053337 chr8:124217698 FAM83A 0.45 6.08 0.32 3.35e-9 Urinary uromodulin levels; CRC cis rs172166 0.637 rs1233691 chr6:28153897 T/G cg06470822 chr6:28175283 NA 0.86 13.52 0.6 1.92e-33 Cardiac Troponin-T levels; CRC cis rs7089973 0.604 rs2181563 chr10:116604344 T/C cg23260525 chr10:116636907 FAM160B1 0.38 9.01 0.45 1.67e-17 Bipolar disorder or attention deficit hyperactivity disorder; CRC cis rs2795502 0.630 rs3004257 chr10:43480529 C/T cg08461752 chr10:43522343 NA -0.85 -7.64 -0.39 2.38e-13 Blood protein levels; CRC cis rs8072100 0.807 rs2175290 chr17:45479917 C/A cg08085267 chr17:45401833 C17orf57 -0.66 -10.86 -0.51 1.08e-23 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs7949030 0.591 rs12049914 chr11:62369436 C/G cg11742103 chr11:62369870 EML3;MTA2 0.62 11.71 0.54 1e-26 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; CRC cis rs6951245 0.554 rs11761322 chr7:1151657 A/G cg21664854 chr7:1097933 C7orf50;GPR146 0.58 7.33 0.37 1.76e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs1044826 0.642 rs1080371 chr3:139210894 C/T cg00490450 chr3:139108681 COPB2 0.44 6.58 0.34 1.89e-10 Obesity-related traits; CRC cis rs11971779 0.793 rs4728464 chr7:139017670 C/T cg07862535 chr7:139043722 LUC7L2 -0.81 -10.35 -0.5 6.47e-22 Diisocyanate-induced asthma; CRC cis rs9381040 0.655 rs2294696 chr6:41036988 A/G cg04346459 chr6:41068666 NFYA;LOC221442 0.43 6.49 0.34 3.23e-10 Alzheimer's disease (late onset); CRC cis rs7618915 0.570 rs11130319 chr3:52755592 A/T cg11645453 chr3:52864694 ITIH4 0.35 5.99 0.31 5.43e-9 Bipolar disorder; CRC cis rs28386778 0.863 rs9897229 chr17:61782325 T/C cg23090583 chr17:61904693 PSMC5;FTSJ3 1.03 18.46 0.71 9.86e-53 Prudent dietary pattern; CRC cis rs4481887 0.861 rs6669290 chr1:248476804 G/A cg13385794 chr1:248469461 NA 0.38 6.71 0.35 8.44e-11 Common traits (Other); CRC cis rs1997103 0.911 rs10238738 chr7:55412359 T/C cg17469321 chr7:55412551 NA 0.74 11.73 0.54 8.65e-27 QRS interval (sulfonylurea treatment interaction); CRC cis rs11249608 0.548 rs62393074 chr5:178450476 G/C cg01312482 chr5:178451176 ZNF879 -0.36 -6.05 -0.32 3.89e-9 Pubertal anthropometrics; CRC cis rs9287719 0.781 rs6714413 chr2:10758859 C/T cg00105475 chr2:10696890 NA 0.45 7.12 0.37 6.81e-12 Prostate cancer; CRC cis rs875971 0.502 rs2465121 chr7:65621004 A/G cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.63 -8.02 -0.4 1.94e-14 Aortic root size; CRC trans rs2243480 0.901 rs778730 chr7:65823325 T/A cg10756647 chr7:56101905 PSPH 0.77 7.84 0.4 6.51e-14 Diabetic kidney disease; CRC cis rs62064224 0.614 rs9900089 chr17:30772577 C/T cg12855166 chr17:30846586 MYO1D -0.35 -5.62 -0.3 4.06e-8 Schizophrenia; CRC trans rs6550704 0.687 rs9865314 chr3:22634337 A/G cg08695707 chr1:197871847 C1orf53 -0.42 -6.18 -0.32 1.88e-9 Daytime sleep phenotypes; CRC cis rs11098499 0.866 rs10518329 chr4:120401835 A/G cg09307838 chr4:120376055 NA 0.7 11.21 0.53 6.32e-25 Corneal astigmatism; CRC cis rs3617 0.539 rs11130331 chr3:52956918 G/A cg15147215 chr3:52552868 STAB1 0.49 8.39 0.42 1.45e-15 Red blood cell count;Autism spectrum disorder or schizophrenia; CRC cis rs10189230 0.546 rs6727259 chr2:222358292 C/G cg14652038 chr2:222343519 EPHA4 -0.37 -6.0 -0.31 5.27e-9 Urate levels in lean individuals; CRC cis rs17376456 0.825 rs10057130 chr5:93282557 C/T cg25358565 chr5:93447407 FAM172A 1.11 10.62 0.51 7.72e-23 Diabetic retinopathy; CRC cis rs9457247 1.000 rs415890 chr6:167406633 C/G cg23791538 chr6:167370224 RNASET2 0.37 5.75 0.3 2.04e-8 Crohn's disease; CRC cis rs11148252 0.574 rs73186430 chr13:53232891 T/C cg02158880 chr13:53174818 NA 0.59 9.28 0.46 2.27e-18 Lewy body disease; CRC cis rs561341 1.000 rs72821971 chr17:30269343 T/G cg23018236 chr17:30244563 NA -0.66 -7.82 -0.4 7.33e-14 Hip circumference adjusted for BMI; CRC cis rs1448094 0.617 rs1354258 chr12:86485647 C/T cg02569458 chr12:86230093 RASSF9 -0.42 -7.14 -0.37 5.87e-12 Major depressive disorder; CRC trans rs9329221 0.527 rs6989657 chr8:10330873 C/G cg06636001 chr8:8085503 FLJ10661 0.49 7.32 0.37 1.92e-12 Neuroticism; CRC cis rs1348850 0.918 rs12622298 chr2:178450651 C/T cg02961200 chr2:178257176 LOC100130691;AGPS 0.48 7.13 0.37 6.28e-12 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs1218582 0.772 rs906593 chr1:154885255 G/A cg03351412 chr1:154909251 PMVK 0.54 8.68 0.43 1.92e-16 Prostate cancer; CRC cis rs10911232 0.524 rs10911209 chr1:183013988 T/G ch.1.3577855R chr1:183094577 LAMC1 0.83 14.57 0.63 1.8e-37 Hypertriglyceridemia; CRC trans rs1933755 0.541 rs59942439 chr6:130920937 A/C cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.92 -6.72 -0.35 7.93e-11 Colorectal cancer (calcium intake interaction); CRC cis rs10028773 0.632 rs34481394 chr4:120248374 C/T cg24375607 chr4:120327624 NA 0.46 7.05 0.36 1.03e-11 Educational attainment; CRC trans rs3733585 0.699 rs12498150 chr4:9950537 C/T cg26043149 chr18:55253948 FECH -0.47 -7.11 -0.36 7.18e-12 Cleft plate (environmental tobacco smoke interaction); CRC cis rs2281845 0.826 rs4915484 chr1:201076917 C/G cg08885800 chr1:201084119 NA 0.39 7.07 0.36 9.44e-12 Permanent tooth development; CRC cis rs7178572 0.568 rs1602925 chr15:77685857 T/C cg22256960 chr15:77711686 NA -0.66 -9.6 -0.47 2.13e-19 Type 2 diabetes; CRC cis rs3018066 0.748 rs10030019 chr4:106998448 G/A cg01869342 chr4:106983673 TBCK 0.44 6.68 0.35 1.04e-10 Cancer; CRC cis rs6690583 1.000 rs6690464 chr1:85466369 A/G cg11262906 chr1:85462892 MCOLN2 -0.53 -7.4 -0.38 1.12e-12 Serum sulfate level; CRC cis rs6424115 0.830 rs3123554 chr1:24196401 C/T cg15997130 chr1:24165203 NA -0.72 -10.91 -0.52 7.63e-24 Immature fraction of reticulocytes; CRC cis rs644799 0.965 rs545342 chr11:95545369 T/C cg03916912 chr11:95522834 CEP57;FAM76B 0.95 18.15 0.71 1.71e-51 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs2019137 0.560 rs10206269 chr2:113990393 C/A cg17445212 chr2:113993313 PAX8;LOC440839;LOC654433 0.48 7.26 0.37 2.89e-12 Lymphocyte counts; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg14715455 chr9:73035436 NA 0.41 5.99 0.31 5.35e-9 Intelligence (multi-trait analysis); CRC cis rs10256972 0.621 rs2363285 chr7:1091644 C/T cg18765753 chr7:1198926 ZFAND2A -0.31 -5.71 -0.3 2.52e-8 Longevity;Endometriosis; CRC cis rs561341 0.714 rs473535 chr17:30312365 A/G cg00745463 chr17:30367425 LRRC37B -0.89 -9.85 -0.48 3.08e-20 Hip circumference adjusted for BMI; CRC cis rs28493229 0.881 rs73931345 chr19:41180347 G/A cg21869046 chr19:41225005 ITPKC 0.44 6.45 0.33 4.07e-10 Kawasaki disease; CRC trans rs9858542 1.000 rs9823546 chr3:49705512 T/A cg21659725 chr3:3221576 CRBN -0.69 -9.05 -0.45 1.32e-17 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs798766 0.953 rs798751 chr4:1719572 A/G cg05874882 chr4:1763078 NA -0.38 -7.06 -0.36 1.02e-11 Bladder cancer;Urinary bladder cancer; CRC trans rs453301 0.686 rs7017868 chr8:8873293 G/A cg16141378 chr3:129829833 LOC729375 0.41 6.04 0.32 4.28e-9 Joint mobility (Beighton score); CRC cis rs12135062 0.755 rs1553287 chr1:3101277 G/A cg25382214 chr1:3105252 PRDM16 -0.47 -7.46 -0.38 7.54e-13 Migraine; CRC trans rs10838798 0.504 rs7479393 chr11:48295303 G/C cg15704280 chr7:45808275 SEPT13 -0.48 -6.78 -0.35 5.66e-11 Height; CRC cis rs4713118 0.869 rs6456802 chr6:27698355 A/G cg21251018 chr6:28226885 NKAPL 0.38 5.71 0.3 2.5e-8 Parkinson's disease; CRC cis rs2032447 0.839 rs199750 chr6:26016462 A/G cg12588279 chr6:26043732 HIST1H2BB -0.48 -7.01 -0.36 1.36e-11 Intelligence (multi-trait analysis); CRC trans rs875971 0.660 rs2191268 chr7:66110224 C/T cg18602325 chr19:44100565 ZNF576;IRGQ -0.38 -6.36 -0.33 6.85e-10 Aortic root size; CRC cis rs73206853 0.841 rs78843188 chr12:110827923 G/C cg12870014 chr12:110450643 ANKRD13A 0.78 8.56 0.43 4.41e-16 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC cis rs9359856 1.000 rs2026650 chr6:90311633 C/G cg13799429 chr6:90582589 CASP8AP2 0.45 6.39 0.33 5.52e-10 Bipolar disorder; CRC cis rs853679 0.517 rs4713152 chr6:28137454 G/A cg12273811 chr6:28175739 NA 0.73 9.16 0.45 5.8e-18 Depression; CRC cis rs476633 0.691 rs28568756 chr15:41539371 G/A cg18705301 chr15:41695430 NDUFAF1 -0.41 -6.85 -0.35 3.54e-11 Glomerular filtration rate (creatinine); CRC cis rs362272 0.525 rs910568 chr4:3307373 A/G cg11522145 chr4:3412961 RGS12 -0.42 -6.49 -0.34 3.18e-10 Serum sulfate level; CRC cis rs11098499 0.754 rs17595608 chr4:120250506 C/T cg09307838 chr4:120376055 NA 0.62 9.59 0.47 2.31e-19 Corneal astigmatism; CRC cis rs644799 1.000 rs3177463 chr11:95502128 G/C cg25622487 chr11:95524042 FAM76B;CEP57 0.74 11.29 0.53 3.34e-25 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs11214589 0.870 rs10789942 chr11:113236199 C/T cg14159747 chr11:113255604 NA -0.57 -11.53 -0.54 4.7e-26 Neuroticism; CRC cis rs9868809 0.649 rs17256786 chr3:48604016 C/G cg00383909 chr3:49044727 WDR6 1.13 7.77 0.39 1.04e-13 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; CRC cis rs6545883 0.929 rs6545877 chr2:61741947 T/C cg15711740 chr2:61764176 XPO1 -0.52 -7.2 -0.37 4.03e-12 Tuberculosis; CRC cis rs1044826 0.642 rs295482 chr3:139229264 A/T cg00490450 chr3:139108681 COPB2 -0.43 -6.45 -0.33 4.1e-10 Obesity-related traits; CRC trans rs2243480 0.908 rs1532573 chr7:65798802 A/G cg10756647 chr7:56101905 PSPH -0.78 -8.02 -0.4 1.83e-14 Diabetic kidney disease; CRC cis rs9916302 0.851 rs6503502 chr17:37501855 A/G cg15445000 chr17:37608096 MED1 -0.44 -9.76 -0.47 6.22e-20 Glomerular filtration rate (creatinine); CRC cis rs743757 1.000 rs2236965 chr3:50453456 T/C cg09545109 chr3:50388910 TUSC4;CYB561D2 0.45 6.41 0.33 5.19e-10 Diastolic blood pressure; CRC cis rs34172651 0.517 rs7204288 chr16:24784531 A/G cg06028605 chr16:24865363 SLC5A11 0.61 9.86 0.48 2.88e-20 Intelligence (multi-trait analysis); CRC cis rs10751667 0.714 rs7396700 chr11:963863 A/C ch.11.42038R chr11:967971 AP2A2 0.58 9.98 0.48 1.16e-20 Alzheimer's disease (late onset); CRC cis rs12541635 0.801 rs12155862 chr8:107105243 G/A cg10147462 chr8:107024639 NA -0.39 -6.05 -0.32 3.92e-9 Age of smoking initiation; CRC cis rs6598955 0.671 rs6681452 chr1:26621101 G/A cg04990556 chr1:26633338 UBXN11 0.54 5.73 0.3 2.22e-8 Obesity-related traits; CRC cis rs6502050 0.805 rs9898507 chr17:80119628 C/T cg02741985 chr17:80059408 CCDC57 0.43 7.15 0.37 5.59e-12 Life satisfaction; CRC cis rs5750830 0.649 rs5750815 chr22:39798449 T/C cg25956985 chr22:39795188 MAP3K7IP1 -0.47 -6.57 -0.34 1.91e-10 Intelligence (multi-trait analysis); CRC cis rs9486719 0.947 rs2499801 chr6:96854594 G/A cg18709589 chr6:96969512 KIAA0776 0.53 5.87 0.31 1.04e-8 Migraine;Coronary artery disease; CRC cis rs1799949 0.550 rs2343818 chr17:41409774 G/A cg01879757 chr17:41196368 BRCA1 -0.41 -6.09 -0.32 3.11e-9 Menopause (age at onset); CRC trans rs6833159 0.527 rs10939231 chr4:28829372 A/T cg23517124 chr12:50419441 RACGAP1 0.42 5.98 0.31 5.95e-9 Underweight status; CRC cis rs2380220 0.576 rs4368819 chr6:96031109 T/G cg15832292 chr6:96025679 MANEA 0.6 6.59 0.34 1.8e-10 Behavioural disinhibition (generation interaction); CRC cis rs10256972 0.524 rs6945202 chr7:1116558 T/C cg23978390 chr7:1156363 C7orf50 0.5 6.88 0.35 3.06e-11 Longevity;Endometriosis; CRC cis rs9733 0.596 rs72702536 chr1:150662574 C/T cg15448220 chr1:150897856 SETDB1 0.46 6.64 0.34 1.28e-10 Tonsillectomy; CRC cis rs76878669 0.519 rs10791869 chr11:66117113 C/T cg18002602 chr11:66138449 SLC29A2 -0.32 -6.69 -0.35 9.45e-11 Educational attainment (years of education); CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg13294780 chr4:140005756 ELF2 -0.41 -6.23 -0.32 1.39e-9 Myopia (pathological); CRC trans rs33794 0.577 rs245213 chr3:45241629 A/G cg00688460 chr12:48922396 NA 0.27 5.97 0.31 6.06e-9 Lung function (forced expiratory volume in 1 second); CRC cis rs7727544 0.904 rs6897575 chr5:131604535 C/T cg14196790 chr5:131705035 SLC22A5 0.34 6.06 0.32 3.69e-9 Blood metabolite levels; CRC cis rs4665809 0.941 rs7602922 chr2:26265782 C/T cg26119090 chr2:26468346 HADHA;HADHB -0.67 -8.32 -0.42 2.35e-15 Gut microbiome composition (summer); CRC trans rs7937682 0.883 rs1789358 chr11:111474116 G/A cg18187862 chr3:45730750 SACM1L 0.46 6.58 0.34 1.83e-10 Primary sclerosing cholangitis; CRC cis rs7216064 0.953 rs12601759 chr17:65955284 A/G cg12091567 chr17:66097778 LOC651250 -0.62 -7.28 -0.37 2.41e-12 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CRC cis rs6558174 0.965 rs1564595 chr8:22488939 A/G cg03733263 chr8:22462867 KIAA1967 0.51 6.79 0.35 5.1e-11 Breast cancer; CRC cis rs3806843 0.838 rs2337514 chr5:140132732 T/C cg16607685 chr5:140181889 PCDHA2;PCDHA1;PCDHA3 0.26 5.93 0.31 7.73e-9 Depressive symptoms (multi-trait analysis); CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg02065795 chr15:64673455 KIAA0101 0.47 6.09 0.32 3.14e-9 Thyroid stimulating hormone; CRC trans rs7819412 0.595 rs2409712 chr8:10986837 A/C cg06636001 chr8:8085503 FLJ10661 -0.48 -7.1 -0.36 7.85e-12 Triglycerides; CRC cis rs7172809 0.607 rs78510848 chr15:77842308 G/C cg10437265 chr15:77819839 NA -0.36 -5.99 -0.31 5.65e-9 Glucose homeostasis traits; CRC cis rs8063761 1.000 rs8063761 chr16:90027626 A/T cg05185784 chr16:90016020 DEF8 0.62 9.13 0.45 7.14e-18 Squamous cell carcinoma; CRC cis rs7208859 0.623 rs216423 chr17:28942109 G/C cg13385521 chr17:29058706 SUZ12P 0.48 6.09 0.32 3.23e-9 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs17443541 0.507 rs971325 chr2:200450294 A/G cg03741458 chr2:200468445 NA -0.38 -5.95 -0.31 6.72e-9 Intelligence (multi-trait analysis); CRC cis rs10174077 0.874 rs4664490 chr2:152471923 C/G cg06191203 chr2:152266755 RIF1 0.57 8.3 0.42 2.79e-15 Squamous cell lung carcinoma; CRC cis rs3820068 0.581 rs74054797 chr1:15926217 G/A cg13390004 chr1:15929781 NA 0.5 7.09 0.36 8.36e-12 Systolic blood pressure; CRC cis rs910316 0.967 rs11159116 chr14:75550584 G/T cg08847533 chr14:75593920 NEK9 0.95 18.79 0.72 5e-54 Height; CRC cis rs6088590 0.687 rs6088580 chr20:33285053 G/C cg08999081 chr20:33150536 PIGU 0.57 10.46 0.5 2.76e-22 Coronary artery disease; CRC cis rs1008375 0.932 rs1008894 chr4:17704667 C/T cg16339924 chr4:17578868 LAP3 -0.49 -6.15 -0.32 2.28e-9 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs17125944 0.615 rs2025632 chr14:53294319 T/C cg00686598 chr14:53173677 PSMC6 -0.63 -6.0 -0.31 5.32e-9 Alzheimer's disease (late onset); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg01099580 chr10:89264946 MINPP1 0.4 6.27 0.33 1.1e-9 Liver disease severity in Alagille syndrome; CRC cis rs889312 0.500 rs252903 chr5:56117952 A/G cg03609598 chr5:56110824 MAP3K1 -0.44 -6.23 -0.32 1.47e-9 Breast cancer;Breast cancer (early onset); CRC cis rs2692947 0.832 rs2438972 chr2:96690873 T/C cg23100626 chr2:96804247 ASTL 0.26 7.11 0.37 7.19e-12 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; CRC cis rs2019137 0.936 rs3828189 chr2:113954496 T/A cg19083407 chr2:113993142 PAX8;LOC440839;LOC654433 -0.46 -6.45 -0.33 4.04e-10 Lymphocyte counts; CRC cis rs7786808 0.741 rs11767875 chr7:158228923 A/G cg15440763 chr7:158190612 PTPRN2 0.41 6.52 0.34 2.63e-10 Obesity-related traits; CRC cis rs9611565 0.694 rs4822032 chr22:41925535 T/C cg06634786 chr22:41940651 POLR3H -0.44 -5.85 -0.31 1.18e-8 Vitiligo; CRC cis rs7917772 0.507 rs2778036 chr10:104485725 G/A cg22532475 chr10:104410764 TRIM8 -0.4 -6.47 -0.34 3.45e-10 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC cis rs2032447 0.772 rs199754 chr6:25992309 A/G cg17691542 chr6:26056736 HIST1H1C 0.43 5.75 0.3 2e-8 Intelligence (multi-trait analysis); CRC cis rs4731207 0.724 rs10229152 chr7:124538285 G/A cg23710748 chr7:124431027 NA -0.38 -6.13 -0.32 2.5e-9 Cutaneous malignant melanoma; CRC cis rs425277 0.585 rs364677 chr1:2071765 A/G cg21194808 chr1:2205498 SKI -0.4 -6.13 -0.32 2.47e-9 Height; CRC cis rs875971 0.862 rs949930 chr7:65766822 C/G cg18876405 chr7:65276391 NA -0.51 -8.42 -0.42 1.17e-15 Aortic root size; CRC cis rs6598955 0.671 rs7417505 chr1:26575523 A/G cg04990556 chr1:26633338 UBXN11 0.56 6.02 0.32 4.53e-9 Obesity-related traits; CRC cis rs1448094 0.511 rs10506920 chr12:86165212 A/T cg18827107 chr12:86230957 RASSF9 -0.39 -5.99 -0.31 5.37e-9 Major depressive disorder; CRC cis rs4319547 0.661 rs10773172 chr12:122939655 G/A cg05707623 chr12:122985044 ZCCHC8 -0.52 -6.84 -0.35 3.87e-11 Body mass index; CRC trans rs8073060 0.586 rs6505486 chr17:33996776 G/A cg19694781 chr19:47549865 TMEM160 -1.07 -14.82 -0.63 2.09e-38 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; CRC cis rs13118159 0.527 rs1250119 chr4:1261336 G/A cg02018176 chr4:1364513 KIAA1530 -0.7 -11.66 -0.54 1.6e-26 Longevity; CRC trans rs12478296 1.000 rs56162244 chr2:243018690 A/G cg18288967 chr1:45987694 PRDX1 0.64 7.23 0.37 3.37e-12 Obesity-related traits; CRC cis rs6952808 0.595 rs3800916 chr7:2166072 C/T cg04267008 chr7:1944627 MAD1L1 -0.63 -8.67 -0.43 1.99e-16 Bipolar disorder and schizophrenia; CRC cis rs713477 0.654 rs6573030 chr14:55913720 T/G cg13175173 chr14:55914753 NA -0.43 -7.74 -0.39 1.23e-13 Pediatric bone mineral content (femoral neck); CRC cis rs367615 0.704 rs72802966 chr5:108846754 T/G cg17395555 chr5:108820864 NA 0.43 8.82 0.44 6.79e-17 Colorectal cancer (SNP x SNP interaction); CRC cis rs10484885 0.690 rs292236 chr6:90528422 A/G cg13799429 chr6:90582589 CASP8AP2 -0.77 -10.7 -0.51 3.89e-23 QRS interval (sulfonylurea treatment interaction); CRC cis rs1552244 0.882 rs7636817 chr3:10014876 G/T cg00166722 chr3:10149974 C3orf24 0.61 7.91 0.4 3.89e-14 Alzheimer's disease; CRC cis rs7662987 0.517 rs1154410 chr4:100006645 A/G cg13256891 chr4:100009986 ADH5 0.62 8.46 0.42 8.8e-16 Smoking initiation; CRC cis rs3733585 0.806 rs11723382 chr4:9954660 T/C cg11266682 chr4:10021025 SLC2A9 -0.51 -10.59 -0.5 9.95e-23 Cleft plate (environmental tobacco smoke interaction); CRC trans rs2228479 0.557 rs12933317 chr16:89828220 A/G cg24644049 chr4:85504048 CDS1 0.86 6.92 0.36 2.32e-11 Skin colour saturation; CRC cis rs11105298 0.891 rs12369685 chr12:89928905 A/G cg08166232 chr12:89918718 WDR51B;GALNT4 -0.59 -7.06 -0.36 9.88e-12 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; CRC cis rs2204008 0.658 rs11495742 chr12:38395688 C/A cg13010199 chr12:38710504 ALG10B 0.47 5.82 0.31 1.4e-8 Bladder cancer; CRC cis rs1997103 1.000 rs10263552 chr7:55404747 C/T cg17469321 chr7:55412551 NA 0.72 11.24 0.53 5.04e-25 QRS interval (sulfonylurea treatment interaction); CRC cis rs703842 1.000 rs2069502 chr12:58144665 A/G cg00677455 chr12:58241039 CTDSP2 -0.64 -8.57 -0.43 4.22e-16 Multiple sclerosis; CRC cis rs72781680 1.000 rs17762102 chr2:24085606 A/G cg08917208 chr2:24149416 ATAD2B 0.92 9.37 0.46 1.23e-18 Lymphocyte counts; CRC cis rs9457247 0.765 rs1322077 chr6:167424293 T/C cg07741184 chr6:167504864 NA 0.39 6.72 0.35 8.06e-11 Crohn's disease; CRC trans rs35110281 0.807 rs9976441 chr21:45046591 G/A cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.43 6.91 0.36 2.52e-11 Mean corpuscular volume; CRC trans rs1814175 0.645 rs1851844 chr11:50021773 T/C cg03929089 chr4:120376271 NA -0.88 -15.84 -0.66 2.09e-42 Height; CRC cis rs2463822 0.669 rs72919475 chr11:62042361 T/A cg06239285 chr11:62104954 ASRGL1 -0.82 -8.26 -0.41 3.54e-15 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs2276314 1.000 rs8086395 chr18:33564592 C/G cg05985134 chr18:33552581 C18orf21 0.46 6.41 0.33 5.06e-10 Endometriosis;Drug-induced torsades de pointes; CRC trans rs3780486 0.846 rs913214 chr9:33135085 G/A cg04842962 chr6:43655489 MRPS18A 1.14 23.72 0.79 3.34e-73 IgG glycosylation; CRC cis rs2073300 0.609 rs17757228 chr20:23351288 A/T cg12062639 chr20:23401060 NAPB 0.71 6.48 0.34 3.29e-10 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs896854 0.654 rs10429443 chr8:95971164 A/G cg16049864 chr8:95962084 TP53INP1 -0.65 -11.83 -0.55 3.9e-27 Type 2 diabetes; CRC cis rs801193 1.000 rs1553610 chr7:66197233 T/C cg18876405 chr7:65276391 NA 0.6 10.62 0.51 7.84e-23 Aortic root size; CRC cis rs9527 0.615 rs36045108 chr10:104697929 G/A cg04362960 chr10:104952993 NT5C2 0.6 8.59 0.43 3.61e-16 Arsenic metabolism; CRC trans rs877282 0.583 rs12358255 chr10:828626 C/T cg22713356 chr15:30763199 NA 0.8 9.26 0.45 2.77e-18 Uric acid levels; CRC cis rs3796352 0.881 rs35384050 chr3:53008769 G/T cg07884673 chr3:53033167 SFMBT1 0.67 5.89 0.31 9.73e-9 Immune reponse to smallpox (secreted IL-2); CRC cis rs3768617 0.510 rs3768624 chr1:183079252 C/T ch.1.3577855R chr1:183094577 LAMC1 0.88 15.62 0.65 1.5e-41 Fuchs's corneal dystrophy; CRC cis rs7937682 1.000 rs12363179 chr11:111568091 G/A cg09085632 chr11:111637200 PPP2R1B 1.02 18.9 0.72 1.81e-54 Primary sclerosing cholangitis; CRC trans rs629535 0.767 rs72654070 chr8:70079369 G/A cg21567404 chr3:27674614 NA -0.94 -15.18 -0.64 8.33e-40 Dupuytren's disease; CRC cis rs7771547 0.573 rs9470274 chr6:36397229 G/A cg04289385 chr6:36355825 ETV7 0.39 5.71 0.3 2.48e-8 Platelet distribution width; CRC cis rs1065852 0.526 rs1062753 chr22:42392811 G/A cg22189786 chr22:42395067 WBP2NL 0.44 6.44 0.33 4.14e-10 Response to serotonin reuptake inhibitors in major depressive disorder (plasma drug and metabolite levels); CRC cis rs863345 0.604 rs6666805 chr1:158498305 G/C cg12129480 chr1:158549410 OR10X1 -0.3 -6.27 -0.33 1.12e-9 Pneumococcal bacteremia; CRC cis rs5769765 0.908 rs9616370 chr22:50306316 A/G cg02269571 chr22:50332266 NA 0.59 7.91 0.4 3.96e-14 Schizophrenia; CRC trans rs2228479 0.867 rs62052185 chr16:89969254 C/T cg24644049 chr4:85504048 CDS1 0.77 7.03 0.36 1.23e-11 Skin colour saturation; CRC cis rs7493 1.000 rs6961773 chr7:95037718 T/G cg04155289 chr7:94953770 PON1 -0.62 -7.74 -0.39 1.21e-13 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs875971 1.000 rs7783613 chr7:65805261 C/T cg00343986 chr7:65444356 GUSB -0.43 -6.19 -0.32 1.8e-9 Aortic root size; CRC cis rs4819052 0.851 rs2838833 chr21:46665160 C/T cg02159808 chr21:46707872 POFUT2;LOC642852 0.47 6.15 0.32 2.25e-9 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs6662572 0.737 rs11211206 chr1:46323192 A/G cg03123370 chr1:45965343 CCDC163P;MMACHC -0.46 -5.9 -0.31 8.93e-9 Blood protein levels; CRC cis rs4862307 0.688 rs6552741 chr4:184990335 A/G cg06737308 chr4:185021514 ENPP6 -0.45 -6.77 -0.35 5.92e-11 Serum dimethylarginine levels (asymmetric/symetric ratio); CRC cis rs9487051 0.872 rs9372211 chr6:109609648 C/T cg21918786 chr6:109611834 NA -0.44 -8.13 -0.41 8.67e-15 Reticulocyte fraction of red cells; CRC cis rs6866344 0.568 rs10516147 chr5:178094484 A/G cg10224037 chr5:178157518 ZNF354A 0.56 7.25 0.37 3.06e-12 Neutrophil percentage of white cells; CRC cis rs10883723 0.775 rs7917158 chr10:104246471 C/A cg22532475 chr10:104410764 TRIM8 -0.35 -6.48 -0.34 3.41e-10 Allergic disease (asthma, hay fever or eczema); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg19988671 chr7:155589783 NA 0.41 6.21 0.32 1.64e-9 Response to antipsychotic treatment; CRC cis rs4631830 0.720 rs2611471 chr10:51503559 G/C cg20129853 chr10:51489980 NA -0.43 -7.21 -0.37 3.76e-12 Prostate-specific antigen levels; CRC cis rs4132509 0.948 rs12136624 chr1:243981611 C/A cg21452805 chr1:244014465 NA 0.49 6.41 0.33 4.95e-10 RR interval (heart rate); CRC cis rs6500395 1.000 rs1486411 chr16:48587083 T/C cg04672837 chr16:48644449 N4BP1 0.45 6.51 0.34 2.87e-10 Response to tocilizumab in rheumatoid arthritis; CRC cis rs6502050 0.835 rs3935816 chr17:80137173 C/T cg19223190 chr17:80058835 NA 0.41 6.45 0.33 4.04e-10 Life satisfaction; CRC cis rs3736485 0.934 rs17609693 chr15:51868000 T/A cg08986416 chr15:51914746 DMXL2 -0.46 -6.64 -0.34 1.33e-10 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs10504229 1.000 rs68112919 chr8:58188247 G/A cg05313129 chr8:58192883 C8orf71 -0.46 -6.95 -0.36 1.96e-11 Developmental language disorder (linguistic errors); CRC trans rs61931739 0.500 rs11053268 chr12:34545121 T/C cg13010199 chr12:38710504 ALG10B 0.45 6.52 0.34 2.65e-10 Morning vs. evening chronotype; CRC cis rs6964587 1.000 rs12536529 chr7:91684086 C/T cg17063962 chr7:91808500 NA -0.78 -13.74 -0.6 2.92e-34 Breast cancer; CRC cis rs9457247 1.000 rs2769347 chr6:167371737 T/A cg23791538 chr6:167370224 RNASET2 0.39 6.08 0.32 3.35e-9 Crohn's disease; CRC cis rs1799949 0.536 rs4793227 chr17:41412250 A/C cg05368731 chr17:41323189 NBR1 0.62 9.32 0.46 1.72e-18 Menopause (age at onset); CRC cis rs425277 0.628 rs262668 chr1:2082602 A/G cg04315214 chr1:2043799 PRKCZ -0.39 -6.64 -0.34 1.27e-10 Height; CRC cis rs1348850 0.874 rs2166558 chr2:178373652 G/T cg02961200 chr2:178257176 LOC100130691;AGPS 0.6 8.63 0.43 2.68e-16 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs12908161 0.959 rs35557864 chr15:85331629 A/G cg11189052 chr15:85197271 WDR73 0.59 8.36 0.42 1.75e-15 Schizophrenia; CRC cis rs2282526 0.615 rs162377 chr21:44926001 A/G cg04455712 chr21:45112962 RRP1B 0.34 5.93 0.31 7.66e-9 Mean corpuscular hemoglobin; CRC trans rs1945213 0.694 rs67394518 chr11:55855303 G/A cg03929089 chr4:120376271 NA 0.58 6.31 0.33 8.87e-10 Acute lymphoblastic leukemia (childhood); CRC cis rs1129187 0.967 rs11752813 chr6:42928017 C/G cg09436375 chr6:42928200 GNMT -0.32 -5.85 -0.31 1.17e-8 Alzheimer's disease in APOE e4+ carriers; CRC cis rs4689388 0.727 rs1801213 chr4:6293696 C/G cg25554036 chr4:6271136 WFS1 0.55 8.53 0.43 5.46e-16 Type 2 diabetes and other traits;Type 2 diabetes; CRC cis rs8072100 0.656 rs2610367 chr17:45569815 A/G cg25173405 chr17:45401733 C17orf57 -0.43 -6.5 -0.34 2.93e-10 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs79349575 0.783 rs903567 chr17:46980318 C/T cg22482690 chr17:47019901 SNF8 0.49 8.2 0.41 5.33e-15 Type 2 diabetes; CRC cis rs3796352 1.000 rs11713206 chr3:52999243 A/G cg06204229 chr3:52865917 ITIH4 0.52 5.86 0.31 1.13e-8 Immune reponse to smallpox (secreted IL-2); CRC cis rs2404602 0.647 rs920712 chr15:77033934 G/A cg23625390 chr15:77176239 SCAPER -0.86 -13.95 -0.61 4.71e-35 Blood metabolite levels; CRC cis rs6942756 0.915 rs6966595 chr7:129006202 A/C cg02491457 chr7:128862824 NA -0.62 -8.3 -0.42 2.78e-15 White matter hyperintensity burden; CRC cis rs6933660 0.745 rs6912830 chr6:151743629 A/C cg14262678 chr6:151773367 RMND1;C6orf211 0.51 8.42 0.42 1.21e-15 Menarche (age at onset); CRC cis rs1448094 0.512 rs10863086 chr12:86244225 G/A cg18827107 chr12:86230957 RASSF9 -0.45 -7.42 -0.38 9.97e-13 Major depressive disorder; CRC cis rs561341 1.000 rs4795668 chr17:30244554 G/A cg12193833 chr17:30244370 NA -0.7 -8.37 -0.42 1.72e-15 Hip circumference adjusted for BMI; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg23526204 chr20:43992176 SYS1;SYS1-DBNDD2 0.42 6.23 0.32 1.43e-9 Intelligence (multi-trait analysis); CRC cis rs2120019 1.000 rs7162900 chr15:75368017 T/C cg17294928 chr15:75287854 SCAMP5 -0.73 -10.86 -0.51 1.1e-23 Blood trace element (Zn levels); CRC cis rs9326248 0.953 rs634960 chr11:117072963 T/C cg15534755 chr11:117069859 TAGLN -0.35 -6.52 -0.34 2.6200000000000003e-10 Blood protein levels; CRC cis rs7089973 0.872 rs35622181 chr10:116631976 C/T cg03647239 chr10:116582469 FAM160B1 0.41 5.62 0.3 4.06e-8 Bipolar disorder or attention deficit hyperactivity disorder; CRC cis rs1008375 0.966 rs6813375 chr4:17649499 T/G cg02297831 chr4:17616191 MED28 0.5 6.71 0.35 8.74e-11 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs1153858 0.887 rs28569043 chr15:45730926 A/T cg21132104 chr15:45694354 SPATA5L1 0.57 8.26 0.41 3.49e-15 Homoarginine levels; CRC cis rs9925964 0.933 rs2359612 chr16:31103796 A/G cg03418659 chr16:31128414 MYST1 -0.44 -6.33 -0.33 8.02e-10 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg25637824 chr1:54304148 TMEM48 0.5 6.91 0.36 2.55e-11 Anxiety disorder; CRC trans rs10506458 0.915 rs1463821 chr12:63402875 C/G cg03429785 chr15:59498649 MYO1E;LDHAL6B 1.32 19.68 0.74 1.61e-57 Hemostatic factors and hematological phenotypes; CRC cis rs12580194 0.593 rs55637917 chr12:55747565 T/C cg23425280 chr12:56401806 NA 0.45 5.62 0.3 4.06e-8 Cancer; CRC cis rs2762353 0.935 rs3757130 chr6:25770866 C/T cg03517284 chr6:25882590 NA 0.47 6.8 0.35 4.93e-11 Blood metabolite levels; CRC cis rs9443189 0.526 rs6902898 chr6:76201856 G/A cg01950844 chr6:76311363 SENP6 0.73 9.69 0.47 1.06e-19 Prostate cancer; CRC cis rs9517320 0.515 rs4772101 chr13:99207554 G/A cg20487152 chr13:99095054 FARP1 -0.44 -6.36 -0.33 6.89e-10 Longevity; CRC cis rs4662945 0.762 rs28510974 chr2:130215288 G/A cg05962382 chr2:130345044 NA -0.36 -6.07 -0.32 3.62e-9 Response to cytidine analogues (gemcitabine); CRC cis rs2404602 0.532 rs12591100 chr15:76700801 C/A cg03037974 chr15:76606532 NA -0.59 -9.67 -0.47 1.26e-19 Blood metabolite levels; CRC cis rs10504229 1.000 rs56350499 chr8:58178139 C/T cg05313129 chr8:58192883 C8orf71 -0.47 -6.99 -0.36 1.49e-11 Developmental language disorder (linguistic errors); CRC cis rs7647973 0.516 rs12490393 chr3:49196132 C/T cg03060546 chr3:49711283 APEH 0.41 5.91 0.31 8.73e-9 Menarche (age at onset); CRC cis rs9388451 0.874 rs9398787 chr6:126090608 A/G cg10911889 chr6:126070802 HEY2 0.38 5.84 0.31 1.29e-8 Brugada syndrome; CRC cis rs7666738 0.535 rs6850010 chr4:98971601 A/T cg17366294 chr4:99064904 C4orf37 0.43 7.07 0.36 9.56e-12 Colonoscopy-negative controls vs population controls; CRC cis rs1223397 0.689 rs2439539 chr6:13308833 G/A cg20827128 chr6:13274284 PHACTR1 0.39 5.96 0.31 6.67e-9 Blood pressure; CRC cis rs7727544 0.904 rs7736102 chr5:131604257 G/A cg14196790 chr5:131705035 SLC22A5 0.34 6.05 0.32 3.84e-9 Blood metabolite levels; CRC cis rs7666738 0.800 rs10008654 chr4:98820498 C/A cg05340658 chr4:99064831 C4orf37 0.53 7.69 0.39 1.72e-13 Colonoscopy-negative controls vs population controls; CRC cis rs10504229 0.683 rs72649188 chr8:58108829 A/G cg24829409 chr8:58192753 C8orf71 -0.56 -7.95 -0.4 3.02e-14 Developmental language disorder (linguistic errors); CRC cis rs1448094 0.511 rs59858864 chr12:86166404 G/A cg02569458 chr12:86230093 RASSF9 0.46 7.6 0.39 3.1400000000000003e-13 Major depressive disorder; CRC cis rs7901135 0.962 rs9415584 chr10:60567917 A/C cg23799393 chr10:60588674 BICC1 0.37 5.67 0.3 3.09e-8 Morning vs. evening chronotype; CRC cis rs13256369 0.901 rs4841015 chr8:8567140 C/G cg17143192 chr8:8559678 CLDN23 0.51 6.71 0.35 8.47e-11 Obesity-related traits; CRC cis rs7429990 0.932 rs6803741 chr3:48123540 C/T cg11946769 chr3:48343235 NME6 -0.45 -5.74 -0.3 2.11e-8 Educational attainment (years of education); CRC cis rs60871478 0.838 rs12530859 chr7:835034 G/A cg05535760 chr7:792225 HEATR2 -1.01 -12.55 -0.57 8.38e-30 Cerebrospinal P-tau181p levels; CRC cis rs6840360 0.582 rs2724555 chr4:152341878 A/G cg09659197 chr4:152720779 NA 0.33 6.5 0.34 2.98e-10 Intelligence (multi-trait analysis); CRC cis rs1862618 0.671 rs72644088 chr5:56241019 G/A cg12311346 chr5:56204834 C5orf35 0.64 9.59 0.47 2.27e-19 Initial pursuit acceleration; CRC cis rs8170 0.603 rs971693 chr19:17422649 G/C cg14325436 chr19:17404977 ABHD8 -0.35 -5.62 -0.3 4.04e-8 Breast cancer (estrogen-receptor negative);Breast Cancer in BRCA1 mutation carriers;Ovarian cancer;Breast cancer;Epithelial ovarian cancer; CRC cis rs3806843 0.808 rs6893708 chr5:140125922 T/C cg16607685 chr5:140181889 PCDHA2;PCDHA1;PCDHA3 0.26 6.05 0.32 4.05e-9 Depressive symptoms (multi-trait analysis); CRC cis rs4319547 0.876 rs10846978 chr12:122964708 T/C cg23029597 chr12:123009494 RSRC2 -0.61 -7.56 -0.38 4.02e-13 Body mass index; CRC cis rs7589728 0.563 rs2292868 chr2:88475047 A/G cg07952391 chr2:88470173 THNSL2 -0.62 -6.22 -0.32 1.51e-9 Plasma clusterin levels; CRC cis rs6484504 0.532 rs2774403 chr11:31320530 A/T cg14844989 chr11:31128820 NA 0.34 6.26 0.33 1.21e-9 Red blood cell count; CRC cis rs6570726 0.791 rs408443 chr6:145874643 T/C cg13319975 chr6:146136371 FBXO30 -0.45 -6.59 -0.34 1.74e-10 Lobe attachment (rater-scored or self-reported); CRC cis rs2645694 0.911 rs2703147 chr4:77831307 C/T cg06046430 chr4:77819534 ANKRD56 0.41 5.68 0.3 2.94e-8 Emphysema distribution in smoking; CRC cis rs7769051 0.708 rs9483514 chr6:133228716 G/A cg22852734 chr6:133119734 C6orf192 0.88 10.32 0.49 8.03e-22 Type 2 diabetes nephropathy; CRC cis rs1552244 1.000 rs9849434 chr3:10133710 A/G cg02579736 chr3:10068473 FANCD2;CIDECP -0.94 -12.88 -0.58 4.97e-31 Alzheimer's disease; CRC cis rs2625529 0.730 rs2929528 chr15:72269337 C/A cg16672083 chr15:72433130 SENP8 0.44 6.39 0.33 5.75e-10 Red blood cell count; CRC cis rs7044106 0.615 rs10818470 chr9:123359204 A/C cg09419670 chr9:123605666 PSMD5;LOC253039 0.62 9.86 0.48 2.92e-20 Hip circumference adjusted for BMI; CRC cis rs9326248 0.559 rs484646 chr11:116732856 A/G cg01368799 chr11:117014884 PAFAH1B2 0.4 6.22 0.32 1.51e-9 Blood protein levels; CRC cis rs2108225 0.900 rs7805114 chr7:107450033 G/T cg18560240 chr7:107437656 SLC26A3 0.6 9.17 0.45 5.15e-18 Ulcerative colitis; CRC cis rs765787 0.530 rs2899379 chr15:45534799 C/T cg24006582 chr15:45444508 DUOX1 0.58 8.45 0.42 9.44e-16 Uric acid levels; CRC cis rs904251 0.523 rs9369005 chr6:37483109 A/G cg25019722 chr6:37503610 NA -0.39 -7.11 -0.36 7.23e-12 Cognitive performance; CRC cis rs12024301 0.557 rs57834388 chr1:183642443 G/A cg11505048 chr1:183622726 RGL1;APOBEC4 0.82 6.81 0.35 4.59e-11 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs72772090 0.539 rs55773007 chr5:96124918 G/A cg17330273 chr5:96107758 CAST;ERAP1 -0.63 -5.96 -0.31 6.43e-9 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC trans rs7267979 1.000 rs4815411 chr20:25350223 A/G cg17903999 chr18:56338584 MALT1 0.44 7.39 0.38 1.24e-12 Liver enzyme levels (alkaline phosphatase); CRC cis rs13108904 0.967 rs900029 chr4:1279145 C/T cg16405210 chr4:1374714 KIAA1530 -0.46 -6.39 -0.33 5.61e-10 Obesity-related traits; CRC cis rs10791323 0.569 rs10791328 chr11:133713730 A/G cg00579200 chr11:133705235 NA -0.4 -5.64 -0.3 3.71e-8 Childhood ear infection; CRC cis rs8067545 0.750 rs4267380 chr17:19971564 A/G cg13482628 chr17:19912719 NA 0.51 8.0 0.4 2.21e-14 Schizophrenia; CRC cis rs6120849 0.708 rs6087659 chr20:33606383 C/A cg08999081 chr20:33150536 PIGU 0.45 5.81 0.31 1.44e-8 Protein C levels; CRC cis rs62229266 0.557 rs4817761 chr21:37395556 C/T cg12218747 chr21:37451666 NA -0.43 -6.75 -0.35 6.5e-11 Mitral valve prolapse; CRC cis rs939584 1.000 rs10865548 chr2:631606 A/G cg03610516 chr2:642275 NA 0.43 5.61 0.3 4.36e-8 Body mass index; CRC cis rs7512552 0.803 rs9436127 chr1:150490565 G/A cg15654264 chr1:150340011 RPRD2 0.59 7.92 0.4 3.63e-14 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); CRC cis rs40363 0.723 rs4785936 chr16:3535116 A/G cg05754148 chr16:3507555 NAT15 -0.68 -6.86 -0.35 3.48e-11 Tuberculosis; CRC cis rs10089 1.000 rs3792866 chr5:127479900 A/G cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.74 10.53 0.5 1.6e-22 Ileal carcinoids; CRC cis rs9611519 0.964 rs5995992 chr22:41487218 T/C cg03806693 chr22:41940476 POLR3H -0.55 -6.96 -0.36 1.8e-11 Neuroticism; CRC cis rs2836974 0.602 rs2836987 chr21:40706594 C/T cg11644478 chr21:40555479 PSMG1 -0.6 -8.96 -0.44 2.4e-17 Cognitive function; CRC trans rs11581859 0.950 rs17392389 chr1:99357704 T/C cg12183875 chr3:169587454 LRRC31 0.27 6.27 0.33 1.12e-9 Response to cognitive-behavioural therapy in anxiety disorder; CRC cis rs4713118 0.869 rs9461405 chr6:27719375 G/T cg02683197 chr6:28174875 NA 0.62 8.6 0.43 3.34e-16 Parkinson's disease; CRC cis rs6834538 0.744 rs11936846 chr4:113409270 G/A cg10021238 chr4:113569128 MIR367;LARP7 -0.4 -6.0 -0.31 5.06e-9 Free thyroxine concentration; CRC cis rs2180341 1.000 rs6569478 chr6:127598619 G/A cg27446573 chr6:127587934 RNF146 0.99 14.76 0.63 3.48e-38 Breast cancer; CRC trans rs208520 0.690 rs4710564 chr6:66823478 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.99 13.72 0.6 3.42e-34 Exhaled nitric oxide output; CRC cis rs317689 0.819 rs317677 chr12:69691806 G/A cg14784868 chr12:69753453 YEATS4 0.45 5.77 0.3 1.79e-8 Response to diuretic therapy; CRC cis rs6879260 1.000 rs6879260 chr5:179731014 A/G cg02891314 chr5:179741120 GFPT2 -0.66 -10.48 -0.5 2.25e-22 Height; CRC cis rs9611565 0.559 rs5758397 chr22:42019251 C/T cg06481639 chr22:41940642 POLR3H 0.53 5.65 0.3 3.43e-8 Vitiligo; CRC cis rs10911390 0.744 rs7552563 chr1:183649620 A/G cg11505048 chr1:183622726 RGL1;APOBEC4 0.6 5.62 0.3 4.06e-8 Systemic lupus erythematosus; CRC cis rs2153535 0.580 rs9505458 chr6:8479215 A/G cg07606381 chr6:8435919 SLC35B3 0.67 10.78 0.51 2.07e-23 Motion sickness; CRC cis rs34779708 0.897 rs12830 chr10:35302705 C/T cg03585969 chr10:35415529 CREM 0.67 8.92 0.44 3.38e-17 Inflammatory bowel disease;Crohn's disease; CRC cis rs10489202 0.657 rs201540 chr1:167992883 G/A cg24449463 chr1:168025552 DCAF6 -0.6 -9.05 -0.45 1.31e-17 Schizophrenia; CRC cis rs1451375 0.617 rs1807066 chr7:50543683 T/C cg14593290 chr7:50529359 DDC -0.64 -8.66 -0.43 2.16e-16 Malaria; CRC cis rs10450586 0.863 rs7123749 chr11:27303855 A/G cg10370305 chr11:27303972 NA 0.4 6.47 0.34 3.45e-10 Total body bone mineral density; CRC cis rs933688 1.000 rs11959525 chr5:90703840 A/G cg02339078 chr5:90679543 LOC100129716;ARRDC3 0.91 13.69 0.6 4.34e-34 Smoking behavior; CRC cis rs10504229 0.683 rs57866073 chr8:58139138 A/G cg05313129 chr8:58192883 C8orf71 -0.46 -6.28 -0.33 1.09e-9 Developmental language disorder (linguistic errors); CRC cis rs524281 0.773 rs2282568 chr11:66052832 C/G cg16950941 chr11:66035639 RAB1B -0.72 -8.12 -0.41 9.39e-15 Electroencephalogram traits; CRC cis rs9486715 0.830 rs2475023 chr6:96996833 G/A cg06623918 chr6:96969491 KIAA0776 -1.04 -20.96 -0.76 1.52e-62 Headache; CRC trans rs877282 0.898 rs10904547 chr10:766283 C/T cg22713356 chr15:30763199 NA 1.27 14.47 0.62 4.65e-37 Uric acid levels; CRC cis rs801193 0.569 rs11772819 chr7:66217970 T/C cg18876405 chr7:65276391 NA 0.51 8.25 0.41 3.87e-15 Aortic root size; CRC cis rs6570726 0.935 rs388394 chr6:145852689 C/T cg23711669 chr6:146136114 FBXO30 0.71 12.47 0.57 1.66e-29 Lobe attachment (rater-scored or self-reported); CRC cis rs2836950 0.565 rs7276046 chr21:40581293 T/C cg06238570 chr21:40685208 BRWD1 -0.62 -9.07 -0.45 1.11e-17 Menarche (age at onset); CRC cis rs6502050 0.799 rs7212023 chr17:80170354 G/A cg02741985 chr17:80059408 CCDC57 0.45 7.41 0.38 1.06e-12 Life satisfaction; CRC trans rs7824557 0.564 rs13274106 chr8:11233958 A/G cg16141378 chr3:129829833 LOC729375 0.42 6.23 0.32 1.42e-9 Retinal vascular caliber; CRC cis rs9527 0.590 rs3861984 chr10:104916980 T/C cg15744005 chr10:104629667 AS3MT -0.31 -6.11 -0.32 2.88e-9 Arsenic metabolism; CRC cis rs9399135 0.967 rs12661423 chr6:135349570 C/T cg22676075 chr6:135203613 NA 0.42 6.75 0.35 6.51e-11 Red blood cell count; CRC cis rs3820068 0.603 rs932602 chr1:15986087 A/G cg13390004 chr1:15929781 NA 0.52 7.28 0.37 2.49e-12 Systolic blood pressure; CRC cis rs6500395 0.926 rs1039344 chr16:48577569 A/G cg04672837 chr16:48644449 N4BP1 0.42 6.06 0.32 3.73e-9 Response to tocilizumab in rheumatoid arthritis; CRC cis rs965469 0.545 rs6051845 chr20:3402792 A/G cg25506879 chr20:3388711 C20orf194 -0.34 -5.86 -0.31 1.12e-8 IFN-related cytopenia; CRC cis rs6502050 0.835 rs55679819 chr17:80105450 C/T cg02741985 chr17:80059408 CCDC57 0.43 7.04 0.36 1.09e-11 Life satisfaction; CRC cis rs12477438 0.765 rs72957180 chr2:99694452 G/A cg14399236 chr2:99771627 LIPT1;TSGA10 -0.74 -10.35 -0.5 6.51e-22 Chronic sinus infection; CRC cis rs990171 0.955 rs2058658 chr2:103054803 T/C cg03938978 chr2:103052716 IL18RAP 0.46 5.91 0.31 8.41e-9 Lymphocyte counts; CRC cis rs4713118 0.621 rs4713134 chr6:28034121 T/C cg15845792 chr6:28175446 NA 0.92 12.48 0.57 1.64e-29 Parkinson's disease; CRC cis rs6964587 0.967 rs7801058 chr7:91784381 C/T cg17063962 chr7:91808500 NA 0.81 14.24 0.62 3.43e-36 Breast cancer; CRC cis rs7945705 0.837 rs10769966 chr11:8847041 C/A cg21881798 chr11:8931708 C11orf17;ST5 0.46 6.84 0.35 3.77e-11 Hemoglobin concentration; CRC cis rs798554 0.797 rs2107964 chr7:2863574 G/A cg13628971 chr7:2884303 GNA12 0.58 7.8 0.39 8.49e-14 Height; CRC cis rs2463822 1.000 rs1406384 chr11:62083530 A/G cg06239285 chr11:62104954 ASRGL1 -0.91 -11.01 -0.52 3.36e-24 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs10256972 0.641 rs12702017 chr7:1129413 C/T cg18402987 chr7:1209562 NA 0.46 6.67 0.35 1.09e-10 Longevity;Endometriosis; CRC cis rs17401966 1.000 rs7530167 chr1:10453374 A/G cg19773385 chr1:10388646 KIF1B -0.58 -8.17 -0.41 6.87e-15 Hepatocellular carcinoma; CRC cis rs6951245 0.554 rs78999139 chr7:1138525 G/A cg22907277 chr7:1156413 C7orf50 0.82 10.63 0.51 7.03e-23 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs4474465 0.920 rs10899526 chr11:78206157 T/C cg27205649 chr11:78285834 NARS2 0.48 6.03 0.32 4.36e-9 Alzheimer's disease (survival time); CRC cis rs3018066 0.666 rs74571473 chr4:107046595 T/C cg01869342 chr4:106983673 TBCK 0.48 6.19 0.32 1.75e-9 Cancer; CRC cis rs9814567 0.964 rs6772406 chr3:134210183 A/G cg06109529 chr3:134205091 CEP63;ANAPC13 -0.81 -12.24 -0.56 1.24e-28 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC trans rs7618501 1.000 rs7649348 chr3:49772375 G/A cg21582582 chr3:182698605 DCUN1D1 -0.56 -8.34 -0.42 2.08e-15 Intelligence (multi-trait analysis); CRC cis rs9549367 0.826 rs35306827 chr13:113869045 G/A cg18105134 chr13:113819100 PROZ -0.7 -10.08 -0.49 5.14e-21 Platelet distribution width; CRC cis rs9868809 0.505 rs73080312 chr3:48737847 C/T cg00383909 chr3:49044727 WDR6 1.3 10.59 0.5 9.7e-23 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; CRC trans rs17685 0.753 rs2286830 chr7:75693963 C/T cg19862616 chr7:65841803 NCRNA00174 -0.99 -18.6 -0.72 2.74e-53 Coffee consumption;Coffee consumption (cups per day); CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg04399615 chr6:142468354 VTA1 0.44 6.08 0.32 3.42e-9 Anxiety disorder; CRC cis rs13343954 0.518 rs2216594 chr19:33533258 G/A cg17764715 chr19:33622953 WDR88 0.38 5.62 0.3 3.97e-8 Colorectal cancer; CRC cis rs6582630 0.638 rs12423236 chr12:38548162 G/A cg26384229 chr12:38710491 ALG10B -0.52 -7.56 -0.38 4.18e-13 Drug-induced liver injury (flucloxacillin); CRC cis rs9322193 0.962 rs3805752 chr6:150116626 C/T cg07701084 chr6:150067640 NUP43 0.58 7.94 0.4 3.29e-14 Lung cancer; CRC cis rs11764590 0.715 rs9969125 chr7:2088460 C/T cg25834613 chr7:1915315 MAD1L1 -0.42 -5.89 -0.31 9.29e-9 Neuroticism; CRC cis rs7552404 1.000 rs1498316 chr1:76159198 G/A cg03433033 chr1:76189801 ACADM 0.81 11.3 0.53 3.09e-25 Blood metabolite levels;Acylcarnitine levels; CRC cis rs6502050 0.871 rs6416857 chr17:80063004 A/G cg22110888 chr17:80059540 CCDC57 -0.42 -6.54 -0.34 2.42e-10 Life satisfaction; CRC cis rs863345 0.564 rs12145401 chr1:158494693 A/G cg12129480 chr1:158549410 OR10X1 -0.29 -5.95 -0.31 6.88e-9 Pneumococcal bacteremia; CRC cis rs853679 0.517 rs4713143 chr6:28106759 A/C cg23161317 chr6:28129485 ZNF389 0.53 6.54 0.34 2.37e-10 Depression; CRC cis rs9487051 0.676 rs6925716 chr6:109597641 T/C cg12927641 chr6:109611667 NA -0.36 -6.47 -0.34 3.47e-10 Reticulocyte fraction of red cells; CRC cis rs72781680 1.000 rs72796388 chr2:24171509 A/C cg08917208 chr2:24149416 ATAD2B 0.91 9.24 0.45 3.06e-18 Lymphocyte counts; CRC cis rs4664293 0.867 rs7566584 chr2:160584795 A/T cg08347373 chr2:160653686 CD302 -0.47 -7.43 -0.38 9.32e-13 Monocyte percentage of white cells; CRC cis rs644799 0.664 rs603625 chr11:95554283 G/A cg03916912 chr11:95522834 CEP57;FAM76B 0.85 15.85 0.66 1.99e-42 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs2276314 0.857 rs28651028 chr18:33638910 G/A cg19628046 chr18:33552617 C18orf21 0.53 7.45 0.38 8.27e-13 Endometriosis;Drug-induced torsades de pointes; CRC cis rs853679 0.517 rs9357063 chr6:28060005 G/A cg02683197 chr6:28174875 NA 0.82 10.03 0.48 7.7e-21 Depression; CRC trans rs116095464 0.558 rs62344345 chr5:257420 C/T cg00938859 chr5:1591904 SDHAP3 0.74 7.9 0.4 4.17e-14 Breast cancer; CRC cis rs1008375 1.000 rs6818639 chr4:17633049 A/G cg16339924 chr4:17578868 LAP3 0.57 7.71 0.39 1.5e-13 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs7937682 0.921 rs1944119 chr11:111436387 A/G cg09085632 chr11:111637200 PPP2R1B 0.95 15.39 0.65 1.21e-40 Primary sclerosing cholangitis; CRC cis rs9303280 0.934 rs56380902 chr17:38066372 T/C cg11212589 chr17:38028394 ZPBP2 0.43 7.77 0.39 1.04e-13 Self-reported allergy; CRC cis rs8067545 0.750 rs3862152 chr17:19959693 C/T cg13482628 chr17:19912719 NA 0.48 7.44 0.38 8.87e-13 Schizophrenia; CRC cis rs7705042 0.793 rs1036207 chr5:141499041 A/G cg07392085 chr5:141489673 NDFIP1 0.47 7.41 0.38 1.07e-12 Asthma; CRC cis rs941408 0.515 rs7253128 chr19:2776982 C/T cg17333051 chr19:2783644 SGTA 0.44 6.67 0.35 1.06e-10 Total cholesterol levels; CRC cis rs4481887 0.927 rs4336885 chr1:248473168 A/C cg13385794 chr1:248469461 NA 0.38 6.63 0.34 1.39e-10 Common traits (Other); CRC cis rs7618915 0.547 rs2164884 chr3:52629633 C/T cg10802521 chr3:52805072 NEK4 -0.59 -9.1 -0.45 8.89e-18 Bipolar disorder; CRC cis rs9916302 0.904 rs3744348 chr17:37417575 C/G cg00129232 chr17:37814104 STARD3 -0.53 -7.85 -0.4 5.96e-14 Glomerular filtration rate (creatinine); CRC cis rs12042938 0.600 rs823165 chr1:231769446 T/A cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX 0.5 7.01 0.36 1.37e-11 Neuranatomic and neurocognitive phenotypes; CRC cis rs1799949 0.965 rs8176130 chr17:41258043 C/T cg23758822 chr17:41437982 NA 0.79 13.42 0.59 4.91e-33 Menopause (age at onset); CRC cis rs11809207 0.523 rs7087 chr1:26496651 T/C cg24519413 chr1:26490540 NA 0.38 6.35 0.33 7.05e-10 Height; CRC cis rs6502050 0.799 rs7501461 chr17:80109806 C/T cg22110888 chr17:80059540 CCDC57 0.4 6.44 0.33 4.17e-10 Life satisfaction; CRC cis rs3825199 0.515 rs2072593 chr12:93970026 T/C cg18151635 chr12:93972918 NA -0.8 -11.58 -0.54 2.97e-26 Height; CRC cis rs2882667 0.690 rs1976562 chr5:138110594 G/A cg09476006 chr5:138032270 NA -0.56 -9.6 -0.47 2.19e-19 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs9467711 0.606 rs9358936 chr6:26370657 A/G cg16898833 chr6:26189333 HIST1H4D 0.76 6.58 0.34 1.88e-10 Autism spectrum disorder or schizophrenia; CRC cis rs919433 0.679 rs1598469 chr2:198515658 T/C cg10820045 chr2:198174542 NA 0.33 5.67 0.3 3.06e-8 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC cis rs1153858 0.725 rs74572151 chr15:45647526 T/G cg14582100 chr15:45693742 SPATA5L1 0.28 5.96 0.31 6.42e-9 Homoarginine levels; CRC cis rs4332037 0.586 rs62442944 chr7:2015047 T/G cg23422044 chr7:1970798 MAD1L1 -0.62 -7.6 -0.39 3.17e-13 Bipolar disorder; CRC cis rs4713118 0.523 rs2179096 chr6:27665920 C/T cg08798685 chr6:27730294 NA -0.39 -5.89 -0.31 9.65e-9 Parkinson's disease; CRC cis rs17401966 0.931 rs12130563 chr1:10428452 G/A cg19773385 chr1:10388646 KIF1B -0.68 -10.98 -0.52 4.16e-24 Hepatocellular carcinoma; CRC trans rs10242455 0.702 rs58348977 chr7:99188014 G/A cg09045935 chr12:6379348 NA 1.15 8.44 0.42 9.95e-16 Blood metabolite levels; CRC cis rs28386778 0.797 rs4968664 chr17:61851366 C/G cg25654072 chr17:61904446 PSMC5;FTSJ3 0.71 11.06 0.52 2.21e-24 Prudent dietary pattern; CRC cis rs9463078 0.691 rs9381361 chr6:45011417 A/C cg25276700 chr6:44698697 NA -0.25 -6.18 -0.32 1.89e-9 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; CRC cis rs1552244 1.000 rs66797209 chr3:10078526 G/A cg16606324 chr3:10149918 C3orf24 0.73 9.77 0.47 5.73e-20 Alzheimer's disease; CRC trans rs2303319 0.582 rs56315911 chr2:162560186 G/T cg18122310 chr12:50236657 BCDIN3D -0.74 -6.45 -0.34 4.07e-10 Cognitive function; CRC cis rs875971 0.862 rs778686 chr7:65835910 C/T cg11764359 chr7:65958608 NA 0.59 9.19 0.45 4.67e-18 Aortic root size; CRC cis rs55665837 1.000 rs10832264 chr11:14459982 T/A cg19336497 chr11:14380999 RRAS2 -0.39 -6.64 -0.34 1.33e-10 Vitamin D levels; CRC cis rs11155671 0.530 rs4869764 chr6:150211828 T/C cg07701084 chr6:150067640 NUP43 0.49 7.05 0.36 1.07e-11 Testicular germ cell tumor; CRC trans rs1814175 0.646 rs61904497 chr11:49883449 A/T cg03929089 chr4:120376271 NA -0.91 -15.93 -0.66 9.48e-43 Height; CRC cis rs6951245 0.554 rs78999139 chr7:1138525 G/A cg03188948 chr7:1209495 NA 0.5 5.96 0.31 6.54e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs4604732 0.631 rs35046441 chr1:247626812 G/A cg12758973 chr1:247694275 LOC148824;OR2C3 0.42 6.14 0.32 2.32e-9 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CRC cis rs6738485 0.601 rs13011900 chr2:106845059 G/C cg15412446 chr2:106886593 NA -0.38 -6.14 -0.32 2.35e-9 Pursuit maintenance gain;Pursuit maintenance gain in psychotic disorders; CRC cis rs17125944 0.505 rs3783447 chr14:53191647 G/A cg00686598 chr14:53173677 PSMC6 1.07 9.9 0.48 2.17e-20 Alzheimer's disease (late onset); CRC cis rs116095464 0.558 rs10057674 chr5:266813 C/T cg22496380 chr5:211416 CCDC127 -0.91 -10.42 -0.5 3.78e-22 Breast cancer; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg26329020 chr12:32909488 YARS2 0.47 6.12 0.32 2.69e-9 Thyroid stimulating hormone; CRC cis rs853679 0.546 rs200490 chr6:27796935 G/T cg06470822 chr6:28175283 NA 0.67 5.84 0.31 1.25e-8 Depression; CRC cis rs2996428 0.601 rs59414187 chr1:3762815 T/C cg13057898 chr1:3703894 LRRC47 0.54 7.1 0.36 7.53e-12 Red cell distribution width; CRC cis rs6860806 0.507 rs582490 chr5:131710095 G/A cg02033258 chr5:131593261 PDLIM4 -0.38 -6.39 -0.33 5.55e-10 Breast cancer; CRC cis rs7847628 0.550 rs12343516 chr9:123603469 A/C cg14255062 chr9:123606675 PSMD5;LOC253039 0.6 10.22 0.49 1.81e-21 Birth weight; CRC cis rs5753618 0.561 rs5753543 chr22:31685458 G/A cg07713946 chr22:31675144 LIMK2 -0.39 -5.64 -0.3 3.6e-8 Colorectal cancer; CRC cis rs2836974 1.000 rs28360661 chr21:40681972 G/C cg11644478 chr21:40555479 PSMG1 0.69 9.7 0.47 9.65e-20 Cognitive function; CRC cis rs243505 0.660 rs3779038 chr7:148542822 C/T cg09806900 chr7:148480153 CUL1 0.52 6.67 0.35 1.07e-10 Inflammatory bowel disease;Crohn's disease; CRC cis rs7666738 0.830 rs6843777 chr4:98866635 T/A cg05340658 chr4:99064831 C4orf37 0.55 8.23 0.41 4.44e-15 Colonoscopy-negative controls vs population controls; CRC cis rs7811142 1.000 rs11763511 chr7:100081944 G/A cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.92 12.27 0.56 9.74e-29 Platelet count; CRC cis rs12692738 0.526 rs355859 chr2:165629520 T/A cg03182029 chr2:165697222 COBLL1 0.5 5.86 0.31 1.11e-8 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);Waist-to-hip ratio adjusted for BMI in non-smokers;Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction);Waist-to-hip ratio adjusted for body mass index; CRC cis rs7927771 1.000 rs4752856 chr11:47648042 C/T cg18512352 chr11:47633146 NA -0.48 -9.57 -0.47 2.62e-19 Subjective well-being; CRC cis rs490234 0.702 rs10986788 chr9:128303942 G/C cg14078157 chr9:128172775 NA -0.39 -6.46 -0.34 3.7e-10 Mean arterial pressure; CRC cis rs7640424 0.819 rs34154497 chr3:107824222 T/C cg09227934 chr3:107805635 CD47 -0.45 -6.53 -0.34 2.56e-10 Body mass index; CRC trans rs7819412 0.749 rs11991118 chr8:10939273 A/C cg16141378 chr3:129829833 LOC729375 -0.39 -5.98 -0.31 5.91e-9 Triglycerides; CRC cis rs8180040 0.654 rs13078131 chr3:47204939 G/T cg02527881 chr3:46936655 PTH1R -0.37 -6.86 -0.35 3.47e-11 Colorectal cancer; CRC cis rs7259376 0.840 rs1985135 chr19:22523578 A/G cg02657401 chr19:22469223 NA -0.38 -8.15 -0.41 7.44e-15 Menopause (age at onset); CRC cis rs2153535 0.580 rs2327067 chr6:8518482 C/G cg07606381 chr6:8435919 SLC35B3 0.66 10.68 0.51 4.6e-23 Motion sickness; CRC cis rs17001868 0.568 rs9607702 chr22:40739177 A/G cg07138101 chr22:40742427 ADSL 0.59 7.84 0.4 6.24e-14 Mammographic density (dense area); CRC cis rs6502050 0.835 rs6502070 chr17:80112634 G/A cg25804541 chr17:80189381 SLC16A3 -0.31 -5.97 -0.31 6.16e-9 Life satisfaction; CRC cis rs62064224 0.714 rs8074594 chr17:30632998 G/A cg21839984 chr17:30846986 MYO1D -0.34 -5.83 -0.31 1.31e-8 Schizophrenia; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg27656398 chr12:123451108 ABCB9 0.39 6.43 0.33 4.61e-10 Liver disease severity in Alagille syndrome; CRC cis rs12762955 0.561 rs7075141 chr10:1091195 C/T cg20503657 chr10:835505 NA -0.42 -6.39 -0.33 5.66e-10 Response to angiotensin II receptor blocker therapy; CRC cis rs5758511 0.680 rs1033459 chr22:42619067 A/G cg00645731 chr22:42541494 CYP2D7P1 0.65 10.12 0.49 3.78e-21 Birth weight; CRC cis rs736801 0.780 rs11951091 chr5:131786595 G/A cg14196790 chr5:131705035 SLC22A5 0.36 5.8 0.3 1.56e-8 Breast cancer;Mosquito bite size; CRC cis rs7224685 0.520 rs12453690 chr17:4037678 T/C cg05562828 chr17:3906858 NA -0.66 -11.4 -0.53 1.3e-25 Type 2 diabetes; CRC cis rs2075371 1.000 rs2598291 chr7:133988313 C/G cg20476274 chr7:133979776 SLC35B4 0.81 14.63 0.63 1.07e-37 Mean platelet volume; CRC cis rs1707322 1.000 rs11211248 chr1:46476844 A/G cg03146154 chr1:46216737 IPP 0.49 6.84 0.35 3.89e-11 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs12893668 0.603 rs12896171 chr14:104135966 A/G cg24130564 chr14:104152367 KLC1 -0.42 -5.63 -0.3 3.82e-8 Reticulocyte count; CRC cis rs7177699 0.550 rs7182716 chr15:79123753 T/C cg15571903 chr15:79123663 NA 0.34 6.92 0.36 2.4e-11 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; CRC cis rs7824557 0.527 rs2736298 chr8:11235136 C/G cg08071915 chr8:12219732 FAM66A 0.32 5.77 0.3 1.82e-8 Retinal vascular caliber; CRC cis rs9372498 0.505 rs9320655 chr6:118830981 T/C cg01339444 chr6:118972232 C6orf204 0.53 6.03 0.32 4.29e-9 Diastolic blood pressure; CRC cis rs6502050 0.528 rs12942561 chr17:80116639 G/A cg22110888 chr17:80059540 CCDC57 0.41 6.5 0.34 2.95e-10 Life satisfaction; CRC cis rs6674970 1.000 rs61819219 chr1:151084375 C/G cg03258749 chr1:151040405 MLLT11 -0.47 -7.28 -0.37 2.55e-12 Childhood ear infection; CRC cis rs1451375 0.959 rs1451373 chr7:50622606 A/G cg14593290 chr7:50529359 DDC 0.55 7.7 0.39 1.65e-13 Malaria; CRC cis rs7615952 0.599 rs67575510 chr3:125742355 C/G cg18479299 chr3:125709523 NA -0.54 -6.28 -0.33 1.04e-9 Blood pressure (smoking interaction); CRC cis rs10504229 1.000 rs66731170 chr8:58187895 C/G cg01721255 chr8:58191610 C8orf71 0.49 6.17 0.32 2e-9 Developmental language disorder (linguistic errors); CRC cis rs988712 0.622 rs4922793 chr11:27729505 A/G cg10635145 chr11:27742435 BDNF -0.41 -6.09 -0.32 3.12e-9 Obesity; CRC cis rs1552244 0.572 rs3894323 chr3:10168967 G/A cg13047869 chr3:10149882 C3orf24 0.53 6.49 0.34 3.25e-10 Alzheimer's disease; CRC cis rs7591163 1.000 rs1721359 chr2:228751874 C/T cg23807890 chr2:228736357 WDR69 -0.49 -6.61 -0.34 1.58e-10 Blood pressure; CRC cis rs7107174 1.000 rs2511169 chr11:77965321 T/C cg02023728 chr11:77925099 USP35 0.49 8.35 0.42 1.88e-15 Testicular germ cell tumor; CRC cis rs9733 0.596 rs7412396 chr1:150666797 C/T cg18016565 chr1:150552671 MCL1 0.45 6.68 0.35 1.02e-10 Tonsillectomy; CRC cis rs1552244 1.000 rs112847840 chr3:10101652 C/T cg13047869 chr3:10149882 C3orf24 0.57 7.8 0.4 8.27e-14 Alzheimer's disease; CRC cis rs4727027 0.769 rs10952797 chr7:148816722 A/T cg12479418 chr7:148823350 ZNF425;ZNF398 0.45 6.04 0.32 4.2e-9 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC cis rs2408955 0.568 rs12099462 chr12:48503104 T/C cg24011408 chr12:48396354 COL2A1 -0.44 -6.49 -0.34 3.25e-10 Glycated hemoglobin levels; CRC cis rs3125734 0.633 rs1864836 chr10:64028538 C/G cg19640130 chr10:64028056 RTKN2 -0.35 -5.67 -0.3 3.12e-8 Rheumatoid arthritis; CRC cis rs7945705 0.902 rs1560569 chr11:8939887 C/T cg14711859 chr11:8959438 ASCL3 0.46 7.47 0.38 7.27e-13 Hemoglobin concentration; CRC cis rs9399137 0.507 rs11758774 chr6:135383789 T/G cg24558204 chr6:135376177 HBS1L 0.61 9.05 0.45 1.29e-17 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; CRC cis rs1448094 0.512 rs61930137 chr12:86242930 C/T cg18827107 chr12:86230957 RASSF9 -0.45 -7.42 -0.38 9.97e-13 Major depressive disorder; CRC cis rs4925386 0.840 rs6143035 chr20:60920700 C/T cg15193198 chr20:60906057 LAMA5 0.42 6.4 0.33 5.48e-10 Colorectal cancer;Colorectal cancer (SNP x SNP interaction); CRC cis rs728616 0.867 rs61859766 chr10:81683040 G/A cg11900509 chr10:81946545 ANXA11 -0.66 -6.66 -0.34 1.14e-10 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs2213920 0.679 rs7047851 chr9:118220718 A/G cg13918206 chr9:118159781 DEC1 -0.65 -6.33 -0.33 8.11e-10 Docetaxel-induced peripheral neuropathy in metastatic castrate-resistant prostate cancer; CRC cis rs2439831 0.702 rs16977724 chr15:44151299 C/T cg02155558 chr15:43621948 ADAL;LCMT2 0.71 7.3 0.37 2.16e-12 Lung cancer in ever smokers; CRC cis rs3731896 0.571 rs77251296 chr2:220193172 A/G cg00436969 chr2:220197716 RESP18 -0.46 -6.09 -0.32 3.14e-9 Educational attainment; CRC cis rs8180040 0.966 rs11914795 chr3:47557722 G/A cg02527881 chr3:46936655 PTH1R -0.39 -7.32 -0.37 1.94e-12 Colorectal cancer; CRC cis rs6866344 0.661 rs72812606 chr5:178129094 A/T cg03877680 chr5:178157825 ZNF354A 0.79 11.3 0.53 3.2e-25 Neutrophil percentage of white cells; CRC cis rs10256972 0.621 rs10951594 chr7:1088607 C/G cg18402987 chr7:1209562 NA 0.39 5.89 0.31 9.65e-9 Longevity;Endometriosis; CRC cis rs950027 0.620 rs1719246 chr15:45625479 T/A cg21132104 chr15:45694354 SPATA5L1 0.42 6.07 0.32 3.57e-9 Response to fenofibrate (adiponectin levels); CRC cis rs2658782 0.789 rs3020057 chr11:93118515 C/T cg15737290 chr11:93063684 CCDC67 0.43 6.35 0.33 7.01e-10 Pulmonary function decline; CRC cis rs12575642 0.660 rs58632573 chr11:63896299 C/T cg05016508 chr11:63871570 FLRT1;MACROD1 0.52 6.67 0.34 1.11e-10 Attention deficit hyperactivity disorder; CRC cis rs9929218 0.906 rs10852450 chr16:68749529 G/A cg02972257 chr16:68554789 NA 0.45 5.65 0.3 3.4e-8 Colorectal cancer; CRC cis rs6582630 0.555 rs11182202 chr12:38476451 C/G cg26384229 chr12:38710491 ALG10B 0.72 10.11 0.49 4.19e-21 Drug-induced liver injury (flucloxacillin); CRC cis rs4253772 0.591 rs8135363 chr22:46651713 T/C cg24881330 chr22:46731750 TRMU 0.57 6.75 0.35 6.69e-11 LDL cholesterol;Cholesterol, total; CRC cis rs11212617 1.000 rs609261 chr11:108158134 T/C cg12106634 chr11:108092400 ATM;NPAT 0.42 6.07 0.32 3.56e-9 Response to metformin in type 2 diabetes (glycemic); CRC cis rs12325245 0.536 rs8058781 chr16:58653838 G/A cg02549819 chr16:58548995 SETD6 1.2 7.97 0.4 2.72e-14 Schizophrenia; CRC cis rs8062405 1.000 rs8055138 chr16:28891465 C/T cg08761264 chr16:28874980 SH2B1 -0.44 -5.85 -0.31 1.2e-8 Cognitive ability (multi-trait analysis);Cognitive ability; CRC cis rs4975616 0.869 rs31490 chr5:1344458 G/A cg06550200 chr5:1325588 CLPTM1L -0.74 -12.07 -0.55 5.1e-28 Lung cancer; CRC cis rs7662987 0.517 rs2602882 chr4:100040765 C/T cg13256891 chr4:100009986 ADH5 0.64 8.54 0.43 5.15e-16 Smoking initiation; CRC cis rs6502050 0.805 rs62078303 chr17:80085210 A/G cg02741985 chr17:80059408 CCDC57 -0.44 -7.15 -0.37 5.61e-12 Life satisfaction; CRC cis rs17253792 0.822 rs78824140 chr14:56042715 G/T cg01858014 chr14:56050164 KTN1 -0.88 -6.92 -0.36 2.4e-11 Putamen volume; CRC cis rs7945705 0.905 rs2568054 chr11:8876029 A/G cg14711859 chr11:8959438 ASCL3 0.46 7.64 0.39 2.32e-13 Hemoglobin concentration; CRC cis rs6938 0.575 rs12909335 chr15:75214789 T/G cg05627522 chr15:75251581 NA 0.41 6.32 0.33 8.65e-10 Breast cancer; CRC cis rs7617773 0.780 rs35778847 chr3:48346985 G/T cg11946769 chr3:48343235 NME6 0.73 9.71 0.47 9.45e-20 Coronary artery disease; CRC cis rs9291683 0.588 rs3733586 chr4:9997534 C/T cg00071950 chr4:10020882 SLC2A9 0.63 11.89 0.55 2.29e-27 Bone mineral density; CRC cis rs8077889 1.000 rs4793035 chr17:41887753 C/T cg26893861 chr17:41843967 DUSP3 0.98 12.81 0.58 9.59e-31 Triglycerides; CRC cis rs875971 0.522 rs709604 chr7:65497434 A/G cg18876405 chr7:65276391 NA -0.65 -11.88 -0.55 2.48e-27 Aortic root size; CRC cis rs228769 0.543 rs170634 chr17:42175821 C/A cg13607699 chr17:42295918 UBTF -0.53 -7.18 -0.37 4.7e-12 Bone mineral density (hip);Bone mineral density (spine); CRC cis rs4819052 0.851 rs9753963 chr21:46661437 G/A cg02159808 chr21:46707872 POFUT2;LOC642852 0.49 6.41 0.33 5.19e-10 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs78456975 0.941 rs28913033 chr2:1523194 T/C cg26248373 chr2:1572462 NA -0.63 -6.54 -0.34 2.3e-10 Placebo response in major depressive disorder (% change in symptom score); CRC cis rs6121246 0.559 rs6060950 chr20:30378031 T/C cg13852791 chr20:30311386 BCL2L1 0.79 15.64 0.65 1.35e-41 Mean corpuscular hemoglobin; CRC cis rs7044106 0.762 rs10739570 chr9:123381222 C/T cg09586646 chr9:123605570 PSMD5;LOC253039 0.61 9.08 0.45 9.99e-18 Hip circumference adjusted for BMI; CRC cis rs9467711 0.606 rs9379852 chr6:26357278 A/G cg14345882 chr6:26364793 BTN3A2 0.64 5.63 0.3 3.85e-8 Autism spectrum disorder or schizophrenia; CRC cis rs3768617 0.903 rs10911251 chr1:183081194 A/C ch.1.3577855R chr1:183094577 LAMC1 0.68 10.38 0.5 5.14e-22 Fuchs's corneal dystrophy; CRC cis rs10479542 0.721 rs6894113 chr5:178974789 G/C cg09060608 chr5:178986726 RUFY1 0.44 7.15 0.37 5.53e-12 Lung cancer; CRC cis rs853679 0.517 rs9368552 chr6:28068426 A/G cg23161317 chr6:28129485 ZNF389 0.52 6.38 0.33 6.1e-10 Depression; CRC cis rs4474465 1.000 rs10751290 chr11:78192707 G/A cg27205649 chr11:78285834 NARS2 -0.48 -5.96 -0.31 6.36e-9 Alzheimer's disease (survival time); CRC cis rs11233250 0.502 rs11233262 chr11:82402077 T/C cg17391194 chr11:82401662 NA 0.44 6.73 0.35 7.69e-11 Glioblastoma;Glioma; CRC cis rs10540 0.558 rs12806062 chr11:501429 G/A cg03934478 chr11:495069 RNH1 0.72 7.64 0.39 2.45e-13 Body mass index; CRC cis rs459193 0.917 rs40270 chr5:55804552 A/C cg26646659 chr5:55776364 NA 0.47 6.29 0.33 1.01e-9 Coronary artery disease;Type 2 diabetes;Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);Waist-to-hip ratio adjusted for BMI in non-smokers;Waist-to-hip ratio adjusted for BMI (smoking interaction);Waist-to-hip ratio adjusted for body mass index;Waist-hip ratio;Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction); CRC cis rs4665809 0.793 rs6546715 chr2:26261520 G/A cg25036284 chr2:26402008 FAM59B -0.44 -5.86 -0.31 1.15e-8 Gut microbiome composition (summer); CRC trans rs1005277 0.505 rs1208689 chr10:38097775 C/G cg17830980 chr10:43048298 ZNF37B -0.4 -6.31 -0.33 9.12e-10 Extrinsic epigenetic age acceleration; CRC cis rs7829975 0.714 rs59046059 chr8:8670736 C/A cg06636001 chr8:8085503 FLJ10661 0.66 10.3 0.49 9.43e-22 Mood instability; CRC cis rs12745968 0.629 rs2145824 chr1:93200401 T/A cg17283838 chr1:93427260 FAM69A -0.45 -6.03 -0.32 4.36e-9 Bipolar disorder and schizophrenia; CRC cis rs56104184 0.775 rs73061694 chr19:49399978 T/C cg21252483 chr19:49399788 TULP2 -0.43 -6.62 -0.34 1.49e-10 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg11522767 chr6:157342961 ARID1B -0.48 -5.98 -0.31 5.8e-9 Diisocyanate-induced asthma; CRC cis rs3820068 0.581 rs12385690 chr1:15932932 A/T cg24675056 chr1:15929824 NA 0.52 7.31 0.37 2.06e-12 Systolic blood pressure; CRC cis rs1862618 0.802 rs832560 chr5:56124423 T/A cg03609598 chr5:56110824 MAP3K1 -0.84 -10.79 -0.51 1.93e-23 Initial pursuit acceleration; CRC cis rs1448094 0.933 rs11117102 chr12:86312720 A/C cg19622623 chr12:86230825 RASSF9 -0.36 -5.85 -0.31 1.22e-8 Major depressive disorder; CRC cis rs10540 1.000 rs116101630 chr11:506826 G/C cg19913688 chr11:428466 ANO9 -0.7 -7.25 -0.37 2.95e-12 Body mass index; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg13275814 chr11:6640775 TPP1 0.42 6.24 0.33 1.34e-9 Intelligence (multi-trait analysis); CRC cis rs9814567 0.896 rs58491661 chr3:134355189 G/T cg06109529 chr3:134205091 CEP63;ANAPC13 0.68 9.79 0.48 4.84e-20 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs6500395 1.000 rs9933237 chr16:48676562 T/C cg04672837 chr16:48644449 N4BP1 0.45 6.67 0.35 1.09e-10 Response to tocilizumab in rheumatoid arthritis; CRC cis rs6088580 0.609 rs6059844 chr20:33036482 A/G cg24642439 chr20:33292090 TP53INP2 0.35 5.93 0.31 7.86e-9 Glomerular filtration rate (creatinine); CRC cis rs79349575 0.783 rs4294857 chr17:46983391 G/A cg22482690 chr17:47019901 SNF8 0.49 8.2 0.41 5.33e-15 Type 2 diabetes; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg04185729 chr11:65382031 MAP3K11 0.42 6.12 0.32 2.7e-9 Intelligence (multi-trait analysis); CRC cis rs9916302 0.706 rs2338799 chr17:37513941 G/A cg07936489 chr17:37558343 FBXL20 0.91 11.42 0.53 1.15e-25 Glomerular filtration rate (creatinine); CRC cis rs7914558 0.899 rs7913682 chr10:104684392 T/A cg04362960 chr10:104952993 NT5C2 0.6 9.08 0.45 1.05e-17 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs2836974 0.897 rs2836929 chr21:40543811 T/C cg17971929 chr21:40555470 PSMG1 0.81 11.76 0.54 6.78e-27 Cognitive function; CRC cis rs4481887 0.927 rs12744455 chr1:248479960 A/G cg00666640 chr1:248458726 OR2T12 0.46 7.89 0.4 4.64e-14 Common traits (Other); CRC cis rs7927771 1.000 rs10838738 chr11:47663049 A/G cg05585544 chr11:47624801 NA -0.62 -11.44 -0.53 9.35e-26 Subjective well-being; CRC cis rs1799949 1.000 rs1960605 chr17:41305397 C/T cg19454999 chr17:41278357 BRCA1;NBR2 0.55 8.63 0.43 2.76e-16 Menopause (age at onset); CRC cis rs9649213 0.574 rs62478236 chr7:98030377 G/A cg00277769 chr7:97922759 BAIAP2L1 -0.58 -9.8 -0.48 4.7e-20 Prostate cancer (SNP x SNP interaction); CRC trans rs1814175 0.817 rs7929173 chr11:49944007 T/C cg21153622 chr11:89784906 NA -0.39 -6.16 -0.32 2.17e-9 Height; CRC cis rs13256369 1.000 rs9329166 chr8:8576655 C/T cg00074818 chr8:8560427 CLDN23 0.4 6.81 0.35 4.65e-11 Obesity-related traits; CRC cis rs1580019 0.922 rs766658 chr7:32499391 C/T cg06627557 chr7:32535165 LSM5;AVL9 0.73 11.39 0.53 1.42e-25 Cognitive ability; CRC cis rs561341 1.000 rs501312 chr17:30329066 A/G cg12193833 chr17:30244370 NA -0.76 -8.88 -0.44 4.33e-17 Hip circumference adjusted for BMI; CRC cis rs3849570 1.000 rs9826270 chr3:81841869 C/T cg07356753 chr3:81810745 GBE1 -0.72 -10.93 -0.52 6.33e-24 Waist circumference;Body mass index; CRC cis rs921968 0.565 rs6761437 chr2:219598092 G/A cg02176678 chr2:219576539 TTLL4 -0.39 -6.36 -0.33 6.9e-10 Mean corpuscular hemoglobin concentration; CRC cis rs2976388 1.000 rs2920294 chr8:143765326 C/G cg20041105 chr8:143859282 LYNX1 -0.33 -5.76 -0.3 1.97e-8 Urinary tract infection frequency; CRC cis rs9911578 0.835 rs723991 chr17:56482039 G/A cg05425664 chr17:57184151 TRIM37 0.44 6.77 0.35 5.94e-11 Intelligence (multi-trait analysis); CRC cis rs4285028 0.747 rs11923248 chr3:121566498 G/T cg20356878 chr3:121714668 ILDR1 -0.47 -6.11 -0.32 2.79e-9 Multiple sclerosis; CRC cis rs6952808 0.729 rs35797753 chr7:1954914 G/A cg22963979 chr7:1858916 MAD1L1 -0.51 -7.58 -0.39 3.52e-13 Bipolar disorder and schizophrenia; CRC cis rs10504229 0.728 rs17804822 chr8:58156276 T/C cg02290350 chr8:58132656 NA -0.5 -6.18 -0.32 1.94e-9 Developmental language disorder (linguistic errors); CRC cis rs172166 0.694 rs203884 chr6:28077374 G/T cg15786705 chr6:28176104 NA 0.61 8.79 0.44 8.77e-17 Cardiac Troponin-T levels; CRC cis rs4660306 0.677 rs10493120 chr1:45903488 C/T cg03123370 chr1:45965343 CCDC163P;MMACHC 0.5 6.55 0.34 2.2e-10 Homocysteine levels; CRC cis rs12936587 0.748 rs11871738 chr17:17525243 A/G cg24612305 chr17:17875800 TOM1L2;LRRC48 -0.43 -5.81 -0.3 1.5e-8 Hip circumference;Coronary artery disease or large artery stroke;Coronary heart disease;Coronary artery disease; CRC cis rs12220238 0.818 rs10430521 chr10:75913590 G/A cg19889307 chr10:75911429 ADK;AP3M1 0.61 5.72 0.3 2.37e-8 Soluble interleukin-2 receptor subunit alpha; CRC cis rs7772486 0.846 rs9373482 chr6:146363123 A/C cg05347473 chr6:146136440 FBXO30 0.36 5.65 0.3 3.5e-8 Lobe attachment (rater-scored or self-reported); CRC cis rs6860806 0.531 rs272888 chr5:131665423 T/C cg18301423 chr5:131593218 PDLIM4 0.37 6.2 0.32 1.72e-9 Breast cancer; CRC cis rs4888262 0.508 rs6564153 chr16:74658723 A/C cg01733217 chr16:74700730 RFWD3 0.74 11.08 0.52 1.84e-24 Testicular germ cell tumor; CRC cis rs7223966 1.000 rs11870797 chr17:61804622 C/T cg05941027 chr17:61774174 LIMD2 0.36 6.4 0.33 5.23e-10 Hip circumference adjusted for BMI;Body mass index; CRC cis rs7223966 1.000 rs9891018 chr17:61827856 A/G cg23090583 chr17:61904693 PSMC5;FTSJ3 0.5 6.28 0.33 1.05e-9 Hip circumference adjusted for BMI;Body mass index; CRC cis rs8177253 0.965 rs8177260 chr3:133480458 T/A cg01448562 chr3:133502909 NA -0.56 -9.92 -0.48 1.88e-20 Iron status biomarkers; CRC trans rs61931739 0.500 rs28692887 chr12:34457075 G/A cg26384229 chr12:38710491 ALG10B 0.66 8.7 0.43 1.63e-16 Morning vs. evening chronotype; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg09789050 chr5:61699876 DIMT1L 0.45 6.13 0.32 2.47e-9 Response to antipsychotic treatment; CRC cis rs6499255 0.904 rs7194753 chr16:69564364 A/G cg04110750 chr16:69646130 NFAT5 0.49 6.89 0.35 2.9e-11 IgE levels; CRC cis rs57221529 0.766 rs72703026 chr5:572383 G/A cg16447950 chr5:562315 NA -0.84 -11.31 -0.53 2.82e-25 Lung disease severity in cystic fibrosis; CRC cis rs9486719 1.000 rs2499816 chr6:96878206 C/T cg06623918 chr6:96969491 KIAA0776 0.81 9.51 0.46 4.17e-19 Migraine;Coronary artery disease; CRC cis rs1580019 0.563 rs34319173 chr7:32585904 G/A cg06627557 chr7:32535165 LSM5;AVL9 0.97 18.36 0.71 2.61e-52 Cognitive ability; CRC cis rs4819052 1.000 rs2297284 chr21:46705345 G/A cg02159808 chr21:46707872 POFUT2;LOC642852 0.64 7.85 0.4 5.96e-14 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs11030122 0.673 rs10835601 chr11:4106416 G/A cg18678763 chr11:4115507 RRM1 -0.56 -8.85 -0.44 5.48e-17 Mean platelet volume;Platelet distribution width; CRC cis rs28386778 0.897 rs1470697 chr17:61799840 T/C cg06601766 chr17:61851465 DDX42;CCDC47 0.44 5.97 0.31 6.3e-9 Prudent dietary pattern; CRC cis rs796364 0.951 rs12613687 chr2:200999256 C/T cg12253985 chr2:200820533 C2orf60;C2orf47 -0.56 -6.02 -0.31 4.73e-9 Schizophrenia; CRC cis rs7119 0.717 rs11635567 chr15:77819515 A/G cg27398640 chr15:77910606 LINGO1 -0.46 -8.03 -0.4 1.79e-14 Type 2 diabetes; CRC cis rs9611519 0.761 rs35445172 chr22:41660301 G/A cg03806693 chr22:41940476 POLR3H -0.64 -8.91 -0.44 3.47e-17 Neuroticism; CRC cis rs3741404 0.620 rs11231722 chr11:63967770 C/G cg15107132 chr11:63991130 FERMT3 -0.38 -6.22 -0.32 1.48e-9 Platelet count; CRC cis rs10504229 1.000 rs113379801 chr8:58173686 C/G cg24829409 chr8:58192753 C8orf71 -0.67 -11.37 -0.53 1.7e-25 Developmental language disorder (linguistic errors); CRC cis rs9807989 0.507 rs2160201 chr2:103033961 T/C cg03938978 chr2:103052716 IL18RAP 0.59 10.13 0.49 3.5e-21 Asthma; CRC cis rs9868809 0.772 rs2302295 chr3:48690110 T/C cg00383909 chr3:49044727 WDR6 0.78 8.36 0.42 1.76e-15 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; CRC cis rs4308124 0.708 rs61358692 chr2:111965159 T/C cg04571233 chr2:111982156 NA -0.55 -8.18 -0.41 6.37e-15 Vitiligo; CRC cis rs4481887 0.604 rs4430368 chr1:248411573 A/G cg00666640 chr1:248458726 OR2T12 0.55 9.08 0.45 1.04e-17 Common traits (Other); CRC cis rs10540 1.000 rs71487296 chr11:500282 G/A cg15790184 chr11:494944 RNH1 0.61 6.26 0.33 1.18e-9 Body mass index; CRC cis rs7804356 1.000 rs73069533 chr7:26892325 G/A cg03456212 chr7:26904342 SKAP2 -0.5 -5.69 -0.3 2.85e-8 Type 1 diabetes; CRC cis rs16867321 1.000 rs16867321 chr2:181362379 C/T cg23363182 chr2:181467187 NA -0.51 -6.17 -0.32 2.02e-9 Obesity; CRC cis rs7666738 0.830 rs6532719 chr4:99043691 A/G cg17366294 chr4:99064904 C4orf37 0.44 7.39 0.38 1.19e-12 Colonoscopy-negative controls vs population controls; CRC trans rs9784649 1.000 rs1493479 chr5:24987768 A/G cg08600765 chr20:34638493 LOC647979 -0.63 -7.6 -0.39 3.21e-13 Peripheral arterial disease (traffic-related air pollution interaction); CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg11530914 chr16:67281528 FHOD1;SLC9A5 0.47 6.17 0.32 2.05e-9 Thyroid stimulating hormone; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg12605341 chr20:18547891 LOC388789 0.42 6.11 0.32 2.79e-9 Intelligence (multi-trait analysis); CRC cis rs7772486 0.713 rs2328704 chr6:146020494 T/C cg13319975 chr6:146136371 FBXO30 0.39 5.77 0.3 1.83e-8 Lobe attachment (rater-scored or self-reported); CRC cis rs9911578 0.967 rs8075786 chr17:56819216 T/C cg12560992 chr17:57184187 TRIM37 0.9 16.62 0.68 1.87e-45 Intelligence (multi-trait analysis); CRC cis rs12681288 0.523 rs6983944 chr8:955147 A/G cg15309053 chr8:964076 NA 0.44 7.87 0.4 5.26e-14 Schizophrenia; CRC trans rs875971 0.660 rs2191268 chr7:66110224 C/T cg12205047 chr1:117209954 IGSF3 -0.4 -6.15 -0.32 2.23e-9 Aortic root size; CRC cis rs9814567 0.806 rs9824185 chr3:134324024 G/C cg06109529 chr3:134205091 CEP63;ANAPC13 -0.68 -10.11 -0.49 4.11e-21 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs40363 0.645 rs1690450 chr16:3521051 G/A cg21433313 chr16:3507492 NAT15 0.57 8.56 0.43 4.35e-16 Tuberculosis; CRC cis rs1223397 0.651 rs2439537 chr6:13307824 C/T cg07912922 chr6:13274314 PHACTR1 0.39 5.96 0.31 6.38e-9 Blood pressure; CRC cis rs2739330 0.828 rs2154593 chr22:24252085 A/G cg18538332 chr22:24372958 LOC391322 -0.71 -11.02 -0.52 3.07e-24 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs861020 0.527 rs614662 chr1:209962419 C/T cg21951975 chr1:209979733 IRF6 -0.35 -6.1 -0.32 2.93e-9 Orofacial clefts; CRC trans rs1578862 1.000 rs6426236 chr1:247434445 A/G cg06850283 chr5:44389769 FGF10 0.25 5.99 0.31 5.49e-9 Monocyte percentage of white cells; CRC cis rs10504229 0.683 rs56208052 chr8:58130207 A/T cg22535103 chr8:58192502 C8orf71 -0.7 -9.34 -0.46 1.47e-18 Developmental language disorder (linguistic errors); CRC cis rs887829 0.641 rs10179094 chr2:234597825 T/A cg07512295 chr2:234599026 UGT1A6;UGT1A10;UGT1A9;UGT1A7;UGT1A8 0.38 5.69 0.3 2.75e-8 Metabolic traits;Bilirubin levels;Cholelithiasis-related traits in sickle cell anemia;Metabolite levels;Total bilirubin levels in HIV-1 infection;Serum metabolite levels;Blood metabolite levels; CRC cis rs9326248 0.590 rs2542063 chr11:116684767 C/T cg11861562 chr11:117069780 TAGLN 0.28 6.42 0.33 4.85e-10 Blood protein levels; CRC cis rs1559088 0.625 rs10411739 chr19:33616327 T/C cg17764715 chr19:33622953 WDR88 0.47 6.97 0.36 1.76e-11 Bone ultrasound measurement (broadband ultrasound attenuation); CRC cis rs8062405 0.756 rs151182 chr16:28495752 C/T cg16576597 chr16:28551801 NUPR1 0.47 6.55 0.34 2.23e-10 Cognitive ability (multi-trait analysis);Cognitive ability; CRC cis rs889398 0.741 rs6499269 chr16:69908918 T/C cg00738113 chr16:70207722 CLEC18C -0.37 -6.21 -0.32 1.63e-9 Body mass index; CRC trans rs7474896 0.537 rs1779068 chr10:38250785 G/A cg05175333 chr18:18692284 ROCK1 -0.48 -6.02 -0.31 4.71e-9 Obesity (extreme); CRC cis rs6860806 0.507 rs272891 chr5:131664394 G/T cg18301423 chr5:131593218 PDLIM4 0.38 6.3 0.33 9.36e-10 Breast cancer; CRC cis rs9910055 0.718 rs2526022 chr17:42213216 C/T cg10896456 chr17:42255109 ASB16;C17orf65 0.45 7.38 0.38 1.27e-12 Total body bone mineral density; CRC cis rs9612 1.000 rs12611034 chr19:44268678 C/T cg08581076 chr19:44259116 C19orf61 0.48 6.15 0.32 2.21e-9 Exhaled nitric oxide output; CRC cis rs9611565 0.659 rs56364401 chr22:41951243 T/G cg06634786 chr22:41940651 POLR3H -0.67 -7.95 -0.4 3.05e-14 Vitiligo; CRC cis rs4975616 0.804 rs381949 chr5:1322468 G/A cg06550200 chr5:1325588 CLPTM1L -0.7 -11.03 -0.52 2.83e-24 Lung cancer; CRC cis rs57221529 0.766 rs72703070 chr5:590458 T/C cg16447950 chr5:562315 NA -0.79 -10.45 -0.5 2.87e-22 Lung disease severity in cystic fibrosis; CRC trans rs4843747 0.671 rs4075998 chr16:88106776 G/A cg26811252 chr16:29126840 RRN3P2 0.61 8.31 0.42 2.62e-15 Menopause (age at onset); CRC cis rs4481887 0.861 rs4497248 chr1:248450525 T/C cg13385794 chr1:248469461 NA 0.36 6.26 0.33 1.21e-9 Common traits (Other); CRC cis rs10256972 0.577 rs6962809 chr7:1208889 A/G cg16145915 chr7:1198662 ZFAND2A -0.54 -11.32 -0.53 2.68e-25 Longevity;Endometriosis; CRC cis rs4638749 1.000 rs12472278 chr2:108873433 A/T cg25838818 chr2:108905173 SULT1C2 0.38 6.15 0.32 2.25e-9 Blood pressure; CRC cis rs6463523 0.815 rs66886645 chr7:763853 C/A cg11064039 chr7:766100 PRKAR1B;HEATR2 0.89 15.98 0.66 6.28e-43 Subjective well-being; CRC cis rs853679 0.517 rs1904840 chr6:28108232 C/T cg15786705 chr6:28176104 NA 0.78 9.83 0.48 3.57e-20 Depression; CRC cis rs4803468 1.000 rs4803468 chr19:41922352 A/G cg09537434 chr19:41945824 ATP5SL -0.97 -18.77 -0.72 5.95e-54 Height; CRC cis rs7605827 0.930 rs1125533 chr2:15617751 C/G cg19274914 chr2:15703543 NA 0.39 5.9 0.31 8.83e-9 Educational attainment (years of education); CRC cis rs763014 0.966 rs4984675 chr16:670117 T/C cg09263875 chr16:632152 PIGQ 0.77 12.1 0.55 4.07e-28 Height; CRC cis rs116095464 0.558 rs6878087 chr5:223117 C/T cg22857025 chr5:266934 NA 1.19 16.66 0.68 1.29e-45 Breast cancer; CRC cis rs1062746 0.527 rs12934628 chr16:87335161 A/G cg02258303 chr16:87377426 FBXO31 -0.51 -7.44 -0.38 8.99e-13 Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 2 peripheral neuropathy); CRC cis rs372883 0.638 rs371432 chr21:30710876 G/A cg24692254 chr21:30365293 RNF160 -0.58 -8.65 -0.43 2.29e-16 Pancreatic cancer; CRC cis rs924607 1.000 rs2455331 chr5:643593 T/C cg09021430 chr5:549028 NA -0.51 -8.43 -0.42 1.12e-15 Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia; CRC cis rs7312933 0.966 rs7977365 chr12:42513127 G/A cg01256987 chr12:42539512 GXYLT1 -0.44 -6.62 -0.34 1.49e-10 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CRC cis rs10504229 1.000 rs67243305 chr8:58174958 G/A cg22535103 chr8:58192502 C8orf71 -0.81 -12.16 -0.56 2.34e-28 Developmental language disorder (linguistic errors); CRC cis rs7586879 0.639 rs4077678 chr2:25122840 C/G cg04586622 chr2:25135609 ADCY3 -0.56 -10.47 -0.5 2.58e-22 Body mass index; CRC cis rs6964587 1.000 rs56072181 chr7:91690457 A/G cg17063962 chr7:91808500 NA 0.8 14.02 0.61 2.36e-35 Breast cancer; CRC cis rs4654899 0.865 rs957163 chr1:21416181 G/T cg02927042 chr1:21476669 EIF4G3 -0.51 -7.72 -0.39 1.45e-13 Superior frontal gyrus grey matter volume; CRC cis rs875971 1.000 rs6945843 chr7:65734783 G/A cg18912574 chr7:65842487 NCRNA00174 -0.36 -6.3 -0.33 9.74e-10 Aortic root size; CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg11865413 chr10:72969054 NA -0.48 -6.05 -0.32 3.88e-9 Diisocyanate-induced asthma; CRC cis rs7666738 0.830 rs13118892 chr4:98968497 T/C cg17366294 chr4:99064904 C4orf37 0.42 7.21 0.37 3.76e-12 Colonoscopy-negative controls vs population controls; CRC cis rs853679 0.517 rs4713143 chr6:28106759 A/C cg12172441 chr6:28176163 NA 0.62 7.4 0.38 1.17e-12 Depression; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg04503171 chr8:110346293 NUDCD1;ENY2 0.42 6.22 0.32 1.48e-9 Intelligence (multi-trait analysis); CRC cis rs7208859 0.623 rs216445 chr17:28933576 A/G cg01831904 chr17:28903510 LRRC37B2 -0.58 -5.94 -0.31 7.45e-9 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs6570726 0.620 rs12201226 chr6:145913419 A/T cg05347473 chr6:146136440 FBXO30 0.49 6.96 0.36 1.83e-11 Lobe attachment (rater-scored or self-reported); CRC cis rs4731207 0.569 rs7799535 chr7:124592060 C/T cg23710748 chr7:124431027 NA -0.38 -6.03 -0.32 4.4e-9 Cutaneous malignant melanoma; CRC trans rs9858542 1.000 rs11718165 chr3:49696797 A/G cg21659725 chr3:3221576 CRBN -0.66 -8.69 -0.43 1.75e-16 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs9549260 0.755 rs7333037 chr13:41215256 A/T cg21288729 chr13:41239152 FOXO1 0.48 7.63 0.39 2.47e-13 Red blood cell count; CRC cis rs10876993 0.821 rs1678522 chr12:58049923 G/A cg15848620 chr12:58087721 OS9 -0.65 -9.03 -0.45 1.54e-17 Celiac disease or Rheumatoid arthritis; CRC trans rs8085804 1.000 rs658728 chr18:40222856 C/T cg00372669 chr10:75571033 NDST2 -0.42 -6.16 -0.32 2.18e-9 Cognitive performance; CRC cis rs10979 0.557 rs9376767 chr6:143909380 G/A cg25407410 chr6:143891975 LOC285740 -0.66 -8.82 -0.44 6.63e-17 Hypospadias; CRC cis rs7726839 0.561 rs4957049 chr5:579080 C/A cg14541582 chr5:601475 NA -0.32 -6.61 -0.34 1.57e-10 Obesity-related traits; CRC cis rs1801251 0.963 rs35362030 chr2:233612845 A/G cg25237894 chr2:233734115 C2orf82 0.54 8.76 0.44 1.03e-16 Coronary artery disease; CRC cis rs995000 0.931 rs1168050 chr1:62986955 C/T cg19896129 chr1:63156450 NA -0.45 -6.99 -0.36 1.56e-11 Triglyceride levels; CRC cis rs17270561 0.609 rs9358883 chr6:25755515 A/G cg17691542 chr6:26056736 HIST1H1C 0.73 9.33 0.46 1.56e-18 Iron status biomarkers; CRC cis rs6570726 0.791 rs398408 chr6:145801020 G/A cg13319975 chr6:146136371 FBXO30 -0.45 -6.82 -0.35 4.32e-11 Lobe attachment (rater-scored or self-reported); CRC cis rs2153535 0.580 rs2225766 chr6:8481833 G/A cg21535247 chr6:8435926 SLC35B3 0.52 8.07 0.41 1.31e-14 Motion sickness; CRC cis rs6433857 0.536 rs1542035 chr2:181351114 T/C cg23363182 chr2:181467187 NA -0.54 -8.14 -0.41 8.3e-15 Body mass index; CRC cis rs10504229 1.000 rs67546820 chr8:58168567 G/A cg02725872 chr8:58115012 NA -0.38 -6.7 -0.35 9.17e-11 Developmental language disorder (linguistic errors); CRC cis rs9435341 0.930 rs61798463 chr1:107565934 G/A cg15468180 chr1:107600409 PRMT6 0.38 5.74 0.3 2.12e-8 Facial morphology (factor 21, depth of nasal alae); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg02328223 chr3:127541927 MGLL 0.38 6.35 0.33 7.25e-10 Liver disease severity in Alagille syndrome; CRC cis rs7089973 0.604 rs11196929 chr10:116582080 G/C cg23260525 chr10:116636907 FAM160B1 0.35 8.06 0.41 1.41e-14 Bipolar disorder or attention deficit hyperactivity disorder; CRC cis rs1018836 0.923 rs12680211 chr8:91633434 C/T cg16814680 chr8:91681699 NA -0.7 -10.85 -0.51 1.21e-23 Ejection fraction in Tripanosoma cruzi seropositivity; CRC cis rs950169 1.000 rs12903820 chr15:84723820 A/G cg24253500 chr15:84953950 NA 0.37 6.26 0.33 1.18e-9 Schizophrenia; CRC cis rs1707322 1.000 rs12060274 chr1:46291062 G/T cg03146154 chr1:46216737 IPP 0.52 7.39 0.38 1.2e-12 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs7274811 0.901 rs17404047 chr20:32305781 A/T cg03904042 chr20:32255491 NECAB3;C20orf134 -0.53 -6.9 -0.36 2.67e-11 Height; CRC trans rs7615952 0.641 rs7632497 chr3:125783086 A/C cg07211511 chr3:129823064 LOC729375 -0.72 -9.73 -0.47 7.91e-20 Blood pressure (smoking interaction); CRC cis rs67311347 1.000 rs7641495 chr3:40494690 T/C cg24209194 chr3:40518798 ZNF619 -0.43 -6.65 -0.34 1.24e-10 Renal cell carcinoma; CRC cis rs9443645 0.901 rs1984195 chr6:79657391 G/A cg09184832 chr6:79620586 NA -0.51 -9.58 -0.47 2.54e-19 Intelligence (multi-trait analysis); CRC cis rs9470366 0.527 rs733590 chr6:36645203 A/G cg08179530 chr6:36648295 CDKN1A 0.7 10.76 0.51 2.4e-23 QRS duration; CRC cis rs4970988 0.556 rs6681426 chr1:150586971 G/A cg18016565 chr1:150552671 MCL1 -0.53 -7.61 -0.39 2.87e-13 Urate levels; CRC cis rs6461049 0.765 rs4719432 chr7:2140330 A/G cg14004847 chr7:1930337 MAD1L1 -0.43 -6.26 -0.33 1.2e-9 Schizophrenia; CRC cis rs13108904 0.935 rs3755920 chr4:1243617 T/C cg20887711 chr4:1340912 KIAA1530 0.43 6.17 0.32 2.03e-9 Obesity-related traits; CRC cis rs11122272 0.701 rs2790894 chr1:231505587 T/A cg06096015 chr1:231504339 EGLN1 0.38 5.68 0.3 2.94e-8 Hemoglobin concentration; CRC cis rs6088580 0.634 rs6141471 chr20:33006730 A/G cg08999081 chr20:33150536 PIGU -0.61 -11.5 -0.54 5.82e-26 Glomerular filtration rate (creatinine); CRC cis rs7615952 0.604 rs9837847 chr3:125623919 G/A cg05084668 chr3:125655381 ALG1L -0.83 -10.26 -0.49 1.33e-21 Blood pressure (smoking interaction); CRC cis rs801193 0.904 rs4718403 chr7:66242729 C/G cg11764359 chr7:65958608 NA 0.52 8.08 0.41 1.24e-14 Aortic root size; CRC cis rs4423214 0.840 rs3794057 chr11:71186744 G/A cg05163923 chr11:71159392 DHCR7 -0.63 -7.61 -0.39 2.92e-13 Vitamin D levels; CRC cis rs1005277 0.579 rs2505240 chr10:38442419 G/T cg00409905 chr10:38381863 ZNF37A -0.67 -11.16 -0.52 9.81e-25 Extrinsic epigenetic age acceleration; CRC cis rs477692 0.583 rs2008387 chr10:131448764 C/T cg05714579 chr10:131428358 MGMT -0.86 -13.56 -0.6 1.36e-33 Response to temozolomide; CRC cis rs10644111 1 rs10644111 chr7:91652178 A/AAAC cg17063962 chr7:91808500 NA 0.83 15.06 0.64 2.36e-39 Breast cancer; CRC cis rs4750440 0.702 rs4748068 chr10:14030692 T/A cg00551146 chr10:14014579 FRMD4A 0.37 5.91 0.31 8.59e-9 Adiponectin levels; CRC cis rs17345786 0.798 rs1609159 chr3:101275902 A/C cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.48 5.9 0.31 8.98e-9 Colonoscopy-negative controls vs population controls; CRC cis rs968567 0.906 rs61897793 chr11:61599347 G/A cg23760165 chr11:61595485 FADS2 -0.45 -5.74 -0.3 2.2e-8 Blood metabolite levels;Rheumatoid arthritis;Vitiligo;Glycerophospholipid levels; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg19947233 chr4:90032727 TIGD2 -0.38 -6.14 -0.32 2.42e-9 Myopia (pathological); CRC cis rs3806843 0.808 rs6893708 chr5:140125922 T/C cg19875535 chr5:140030758 IK -0.52 -8.31 -0.42 2.55e-15 Depressive symptoms (multi-trait analysis); CRC cis rs10870270 0.957 rs9971084 chr10:133788747 G/C cg17892150 chr10:133769511 PPP2R2D -0.75 -11.33 -0.53 2.39e-25 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; CRC cis rs10197940 0.662 rs6735771 chr2:152273503 G/A cg19508488 chr2:152266495 RIF1 -0.52 -7.65 -0.39 2.2e-13 Lung cancer; CRC cis rs10540 1.000 rs35811812 chr11:498442 G/A cg21784768 chr11:537496 LRRC56 -0.59 -5.92 -0.31 8.31e-9 Body mass index; CRC cis rs9916302 0.904 rs4795384 chr17:37716771 C/G cg07936489 chr17:37558343 FBXL20 -0.86 -13.32 -0.59 1.09e-32 Glomerular filtration rate (creatinine); CRC cis rs2274273 0.837 rs10141483 chr14:55786871 T/C cg23234261 chr14:55582407 NA -0.29 -5.78 -0.3 1.73e-8 Protein biomarker; CRC cis rs4919694 1.000 rs11191445 chr10:104651055 C/T cg04362960 chr10:104952993 NT5C2 1.13 10.19 0.49 2.34e-21 Arsenic metabolism; CRC cis rs6502050 0.835 rs7221451 chr17:80089785 A/G cg13198984 chr17:80129470 CCDC57 0.5 8.76 0.43 1.06e-16 Life satisfaction; CRC cis rs12586317 0.511 rs11540758 chr14:35498485 C/T cg16230307 chr14:35515116 FAM177A1 0.9 10.55 0.5 1.36e-22 Psoriasis; CRC cis rs6952808 1.000 rs6954673 chr7:1886937 C/T cg04267008 chr7:1944627 MAD1L1 -0.76 -10.84 -0.51 1.32e-23 Bipolar disorder and schizophrenia; CRC cis rs11098499 0.863 rs3775845 chr4:120432447 T/C cg09307838 chr4:120376055 NA 0.68 10.32 0.49 8.02e-22 Corneal astigmatism; CRC cis rs2120019 1.000 rs12324912 chr15:75361006 G/A cg17294928 chr15:75287854 SCAMP5 -0.77 -11.65 -0.54 1.72e-26 Blood trace element (Zn levels); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg25750404 chr12:6579648 VAMP1 0.48 6.82 0.35 4.29e-11 Response to antipsychotic treatment; CRC cis rs40363 0.672 rs1617722 chr16:3520806 C/T cg05754148 chr16:3507555 NAT15 -0.51 -7.12 -0.37 6.9e-12 Tuberculosis; CRC trans rs7267979 1.000 rs2482930 chr20:25334115 G/C cg17903999 chr18:56338584 MALT1 0.42 6.97 0.36 1.73e-11 Liver enzyme levels (alkaline phosphatase); CRC trans rs2303319 0.504 rs62188990 chr2:162540635 G/A cg22988483 chr14:93581567 ITPK1 -0.67 -6.08 -0.32 3.35e-9 Cognitive function; CRC cis rs7932354 0.528 rs11039112 chr11:47174296 C/T cg03339077 chr11:47165057 C11orf49 -0.46 -6.51 -0.34 2.81e-10 Bone mineral density (hip);Bone mineral density; CRC cis rs9487051 0.676 rs1608042 chr6:109595631 G/A cg01475377 chr6:109611718 NA -0.37 -6.58 -0.34 1.85e-10 Reticulocyte fraction of red cells; CRC trans rs7939886 0.920 rs58405266 chr11:55863225 G/A cg03929089 chr4:120376271 NA 0.66 5.96 0.31 6.44e-9 Myopia (pathological); CRC cis rs7954584 0.567 rs1720037 chr12:122382229 G/T cg21171335 chr12:122356390 WDR66 -0.38 -5.85 -0.31 1.16e-8 Mean corpuscular volume; CRC cis rs6502050 0.835 rs9902485 chr17:80093701 C/T cg25804541 chr17:80189381 SLC16A3 -0.3 -5.85 -0.31 1.19e-8 Life satisfaction; CRC cis rs1009181 0.585 rs2183947 chr6:26159356 G/A cg00631329 chr6:26305371 NA -0.44 -6.52 -0.34 2.68e-10 Childhood ear infection; CRC trans rs7615952 0.866 rs6438949 chr3:125650064 G/C cg21747405 chr11:67723411 NA -0.44 -6.28 -0.33 1.06e-9 Blood pressure (smoking interaction); CRC trans rs12431410 0.550 rs10138254 chr14:60209188 A/G cg00680277 chr2:3465103 TTC15 -0.37 -5.97 -0.31 6.19e-9 Schizophrenia; CRC cis rs4728302 0.869 rs6955707 chr7:133612188 G/A cg10665199 chr7:133106180 EXOC4 0.37 5.6 0.3 4.49e-8 Intelligence;Intelligence (multi-trait analysis); CRC cis rs28386778 0.897 rs9906247 chr17:61857314 T/C cg25654072 chr17:61904446 PSMC5;FTSJ3 0.74 11.58 0.54 2.99e-26 Prudent dietary pattern; CRC cis rs12893668 0.572 rs4900591 chr14:104154878 G/A cg01849466 chr14:104193079 ZFYVE21 -0.4 -5.86 -0.31 1.15e-8 Reticulocyte count; CRC cis rs7618915 0.547 rs6762813 chr3:52726695 C/T cg07507251 chr3:52567010 NT5DC2 0.46 6.64 0.34 1.32e-10 Bipolar disorder; CRC cis rs79387448 0.745 rs59126438 chr2:103165142 T/G cg09003973 chr2:102972529 NA 0.73 8.05 0.41 1.48e-14 Gut microbiota (bacterial taxa); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg23506944 chr17:28257236 EFCAB5;SSH2 0.43 6.82 0.35 4.39e-11 Liver disease severity in Alagille syndrome; CRC cis rs17270561 0.666 rs9356988 chr6:25777481 G/A cg16482183 chr6:26056742 HIST1H1C 0.76 9.46 0.46 5.88e-19 Iron status biomarkers; CRC cis rs7809950 1.000 rs17154077 chr7:107077941 C/T cg23024343 chr7:107201750 COG5 0.6 8.77 0.44 9.84e-17 Coronary artery disease; CRC trans rs9929218 0.954 rs7198799 chr16:68818390 C/T cg04657470 chr2:198365150 HSPE1;HSPD1 -0.81 -11.55 -0.54 3.9e-26 Colorectal cancer; CRC trans rs208515 0.525 rs10455593 chr6:66691341 C/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.95 12.11 0.56 3.56e-28 Exhaled nitric oxide levels; CRC cis rs6570726 0.791 rs11759979 chr6:145918881 C/T cg23711669 chr6:146136114 FBXO30 0.76 12.91 0.58 3.84e-31 Lobe attachment (rater-scored or self-reported); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg07308943 chr2:29093510 TRMT61B 0.47 6.6 0.34 1.63e-10 Response to antipsychotic treatment; CRC cis rs1799949 1.000 rs1799966 chr17:41223094 T/C cg01879757 chr17:41196368 BRCA1 -0.43 -6.54 -0.34 2.4e-10 Menopause (age at onset); CRC trans rs6951245 0.638 rs74976697 chr7:1160505 C/T cg13565492 chr6:43139072 SRF -0.72 -8.02 -0.4 1.84e-14 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs6545883 0.895 rs2177961 chr2:61560264 T/C cg15711740 chr2:61764176 XPO1 0.44 6.02 0.31 4.77e-9 Tuberculosis; CRC cis rs9487051 0.872 rs6924776 chr6:109612276 A/G cg21918786 chr6:109611834 NA -0.45 -8.31 -0.42 2.55e-15 Reticulocyte fraction of red cells; CRC cis rs1448094 0.512 rs7137596 chr12:86239884 C/G cg00310523 chr12:86230176 RASSF9 0.34 5.79 0.3 1.67e-8 Major depressive disorder; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg18523979 chr3:13009124 IQSEC1 -0.4 -6.28 -0.33 1.06e-9 Myopia (pathological); CRC cis rs4713118 0.662 rs149948 chr6:27974817 C/G cg10876282 chr6:28092338 ZSCAN16 0.44 5.83 0.31 1.31e-8 Parkinson's disease; CRC cis rs9905704 0.647 rs9898048 chr17:57108543 C/T cg12560992 chr17:57184187 TRIM37 0.66 10.24 0.49 1.56e-21 Testicular germ cell tumor; CRC cis rs889312 0.500 rs252920 chr5:56148741 C/A cg18230493 chr5:56204884 C5orf35 -0.39 -5.85 -0.31 1.21e-8 Breast cancer;Breast cancer (early onset); CRC cis rs60871478 0.579 rs56109762 chr7:925967 G/A cg05535760 chr7:792225 HEATR2 -0.95 -9.69 -0.47 1.09e-19 Cerebrospinal P-tau181p levels; CRC trans rs61931739 0.500 rs28624237 chr12:34457171 G/T cg26384229 chr12:38710491 ALG10B 0.66 8.7 0.43 1.63e-16 Morning vs. evening chronotype; CRC trans rs7873102 0.702 rs7028020 chr9:38007747 C/T cg14479329 chr6:167370587 RNASET2 -0.41 -6.2 -0.32 1.7e-9 Brain structure; CRC cis rs7258465 0.931 rs7249020 chr19:18608147 A/G cg01065977 chr19:18549689 ISYNA1 -0.41 -6.43 -0.33 4.42e-10 Breast cancer; CRC cis rs6547741 0.935 rs6547738 chr2:27852637 A/G cg27432699 chr2:27873401 GPN1 0.79 13.91 0.61 6.53e-35 Oral cavity cancer; CRC cis rs6121246 0.567 rs2811 chr20:30194248 A/G cg18721089 chr20:30220636 NA -0.52 -7.93 -0.4 3.54e-14 Mean corpuscular hemoglobin; CRC cis rs4466137 0.951 rs336958 chr5:82973396 A/G cg15083037 chr5:83017644 HAPLN1 -0.46 -5.73 -0.3 2.25e-8 Prostate cancer; CRC cis rs514406 0.893 rs479569 chr1:53352407 C/T cg25767906 chr1:53392781 SCP2 -0.49 -7.81 -0.4 7.71e-14 Monocyte count; CRC cis rs10206020 0.879 rs72778007 chr2:1573178 C/T cg26248373 chr2:1572462 NA -0.86 -12.69 -0.57 2.63e-30 IgG glycosylation; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg14780845 chr17:41323115 NBR1 0.5 8.41 0.42 1.25e-15 Liver disease severity in Alagille syndrome; CRC cis rs9648716 1.000 rs7798031 chr7:140602599 C/A cg10747023 chr7:140774559 NA 0.45 5.9 0.31 9.21e-9 Type 2 diabetes; CRC cis rs9457247 1.000 rs413232 chr6:167400972 G/A cg23791538 chr6:167370224 RNASET2 -0.38 -5.94 -0.31 7.32e-9 Crohn's disease; CRC cis rs1023500 0.551 rs2859438 chr22:42466980 A/T cg15557168 chr22:42548783 NA -0.38 -6.43 -0.33 4.43e-10 Schizophrenia; CRC cis rs11785400 0.793 rs9297970 chr8:143723386 C/T cg10596483 chr8:143751796 JRK 0.47 6.37 0.33 6.37e-10 Schizophrenia; CRC cis rs847577 0.569 rs7804318 chr7:97796635 A/G cg00277769 chr7:97922759 BAIAP2L1 0.38 6.33 0.33 8.02e-10 Breast cancer; CRC cis rs10504229 0.683 rs17194487 chr8:58104912 C/T cg05313129 chr8:58192883 C8orf71 -0.48 -5.67 -0.3 3.19e-8 Developmental language disorder (linguistic errors); CRC cis rs7762018 0.607 rs77392231 chr6:170057634 G/A cg24289452 chr6:170231220 NA -0.81 -7.16 -0.37 5.4e-12 Thiazide-induced adverse metabolic effects in hypertensive patients; CRC cis rs9435341 0.826 rs17496332 chr1:107546375 C/T cg14828511 chr1:107599125 PRMT6 -0.49 -6.86 -0.35 3.49e-11 Facial morphology (factor 21, depth of nasal alae); CRC trans rs1991651 0.578 rs11778453 chr8:10489836 C/G cg06636001 chr8:8085503 FLJ10661 -0.47 -6.75 -0.35 6.53e-11 Granulocyte count;Neutrophil count;Myeloid white cell count;Sum basophil neutrophil counts;Sum neutrophil eosinophil counts; CRC cis rs6540556 0.954 rs7548219 chr1:209936466 A/G cg23920097 chr1:209922102 NA -0.53 -6.67 -0.35 1.06e-10 Red blood cell count; CRC cis rs1129187 0.755 rs7760250 chr6:42929839 G/A cg27588902 chr6:42928151 GNMT -0.39 -7.22 -0.37 3.71e-12 Alzheimer's disease in APOE e4+ carriers; CRC cis rs7945705 0.934 rs1988709 chr11:8882890 A/T cg14711859 chr11:8959438 ASCL3 -0.5 -8.22 -0.41 4.9e-15 Hemoglobin concentration; CRC cis rs41005 1.000 rs34505904 chr2:8115159 T/C cg03155496 chr2:8117019 LOC339788 -0.39 -6.72 -0.35 8.04e-11 Response to anti-TNF therapy in rheumatoid arthritis; CRC cis rs17095355 0.892 rs7085888 chr10:111713930 A/G cg00817464 chr10:111662876 XPNPEP1 0.57 7.88 0.4 4.8e-14 Biliary atresia; CRC cis rs875971 0.545 rs73136346 chr7:65566082 A/G cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.62 -7.89 -0.4 4.62e-14 Aortic root size; CRC trans rs2228479 0.850 rs45567439 chr16:89814604 G/A cg21302420 chr1:112162376 RAP1A 0.72 6.01 0.31 5.05e-9 Skin colour saturation; CRC cis rs910316 0.737 rs2098251 chr14:75492696 G/A cg03030879 chr14:75389066 RPS6KL1 -0.41 -6.21 -0.32 1.59e-9 Height; CRC cis rs7772486 0.790 rs2265472 chr6:146220758 G/C cg23711669 chr6:146136114 FBXO30 0.71 12.63 0.57 4.28e-30 Lobe attachment (rater-scored or self-reported); CRC cis rs9814567 0.806 rs11927539 chr3:134319448 C/G cg06109529 chr3:134205091 CEP63;ANAPC13 -0.68 -10.12 -0.49 3.94e-21 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs6495122 0.501 rs12904227 chr15:75387048 A/C cg14664628 chr15:75095509 CSK 0.4 5.88 0.31 9.88e-9 Caffeine consumption;Diastolic blood pressure;Coffee consumption; CRC cis rs889398 0.774 rs6499263 chr16:69890149 T/C cg00738113 chr16:70207722 CLEC18C -0.37 -6.28 -0.33 1.08e-9 Body mass index; CRC cis rs4964805 0.594 rs10861095 chr12:104165387 A/G cg02344784 chr12:104178138 NT5DC3 0.47 7.23 0.37 3.35e-12 Attention deficit hyperactivity disorder; CRC cis rs11690935 0.959 rs7572215 chr2:172634228 G/A cg13550731 chr2:172543902 DYNC1I2 -1.06 -17.46 -0.69 9.32e-49 Schizophrenia; CRC cis rs4819052 0.851 rs2838858 chr21:46681093 T/A cg11663144 chr21:46675770 NA -0.82 -13.88 -0.61 8.15e-35 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs2404602 0.647 rs10152247 chr15:76942252 T/G cg03037974 chr15:76606532 NA -0.53 -7.98 -0.4 2.51e-14 Blood metabolite levels; CRC cis rs921968 0.613 rs2303566 chr2:219557738 C/T cg02176678 chr2:219576539 TTLL4 -0.45 -7.19 -0.37 4.35e-12 Mean corpuscular hemoglobin concentration; CRC cis rs11971779 0.590 rs6944104 chr7:139051120 T/A cg23387468 chr7:139079360 LUC7L2 0.41 7.04 0.36 1.14e-11 Diisocyanate-induced asthma; CRC cis rs853679 0.513 rs9468296 chr6:28113730 A/G cg12172441 chr6:28176163 NA 0.64 7.53 0.38 5.03e-13 Depression; CRC cis rs3026101 0.671 rs2871210 chr17:5305027 G/C cg25236894 chr17:5323110 RPAIN;NUP88 0.42 6.89 0.35 2.9100000000000002e-11 Body mass index; CRC trans rs4942242 0.640 rs17538959 chr13:44229911 T/G cg27382691 chr15:76552771 ETFA;TYRO3P -0.47 -5.97 -0.31 6.15e-9 Response to tocilizumab in rheumatoid arthritis; CRC cis rs6499188 0.522 rs10153230 chr16:68671741 C/G cg02972257 chr16:68554789 NA -0.49 -6.43 -0.33 4.39e-10 Ulcerative colitis; CRC cis rs1218582 0.628 rs12130132 chr1:154880386 C/T cg16680214 chr1:154839983 KCNN3 -0.51 -9.08 -0.45 9.89e-18 Prostate cancer; CRC trans rs853679 0.546 rs200990 chr6:27815823 T/G cg06606381 chr12:133084897 FBRSL1 -0.74 -6.49 -0.34 3.18e-10 Depression; CRC cis rs1046896 0.514 rs67735447 chr17:80823042 G/T cg19500275 chr17:80737654 TBCD 0.51 7.09 0.36 8.31e-12 Glycated hemoglobin levels; CRC cis rs1545257 0.537 rs11125582 chr2:24646213 C/T cg06627628 chr2:24431161 ITSN2 -0.48 -7.16 -0.37 5.17e-12 Sjögren's syndrome; CRC cis rs514406 0.861 rs551435 chr1:53260537 G/T cg24675658 chr1:53192096 ZYG11B 0.56 8.16 0.41 6.94e-15 Monocyte count; CRC cis rs4243830 0.850 rs2274553 chr1:6586553 C/T cg05709478 chr1:6581295 PLEKHG5 -0.51 -6.45 -0.33 4.1e-10 Body mass index; CRC cis rs400736 0.930 rs408320 chr1:8085328 T/C cg25007680 chr1:8021821 PARK7 0.53 7.44 0.38 8.65e-13 Response to antidepressants and depression; CRC cis rs7849270 1.000 rs4713 chr9:131910805 A/T cg13538475 chr9:131942899 NA 0.33 6.49 0.34 3.13e-10 Blood metabolite ratios; CRC cis rs17067123 0.614 rs6850226 chr4:180052577 T/G cg26610307 chr4:180072759 NA -0.57 -6.9 -0.36 2.66e-11 Response to hepatitis C treatment; CRC cis rs9311676 0.656 rs12497250 chr3:58399399 T/C cg06643156 chr3:58380774 PXK 0.42 6.38 0.33 5.84e-10 Systemic lupus erythematosus; CRC cis rs10504229 1.000 rs34616626 chr8:58184650 C/T cg05313129 chr8:58192883 C8orf71 -0.47 -6.99 -0.36 1.49e-11 Developmental language disorder (linguistic errors); CRC cis rs12681287 0.640 rs2953516 chr8:87332545 C/T cg27223183 chr8:87520930 FAM82B -0.49 -6.45 -0.34 4.01e-10 Caudate activity during reward; CRC trans rs3749237 0.964 rs7431078 chr3:49808190 G/A cg21665057 chr3:196295764 WDR53;FBXO45 0.55 7.78 0.39 9.69e-14 Resting heart rate; CRC cis rs1976403 0.633 rs1697422 chr1:21821897 T/C cg02390115 chr1:21767211 NBPF3 0.53 7.91 0.4 3.88e-14 Liver enzyme levels (alkaline phosphatase); CRC cis rs6502050 0.723 rs11650633 chr17:80083807 T/C cg22110888 chr17:80059540 CCDC57 -0.41 -6.51 -0.34 2.75e-10 Life satisfaction; CRC cis rs6445967 1.000 rs9847151 chr3:58285808 G/A cg23715586 chr3:58305044 RPP14 0.36 6.18 0.32 1.89e-9 Platelet count; CRC cis rs9910055 0.762 rs184478 chr17:42209751 C/G cg19774624 chr17:42201019 HDAC5 0.63 9.25 0.45 2.95e-18 Total body bone mineral density; CRC trans rs925098 0.577 rs2724470 chr4:17996046 A/G cg20047235 chr7:150755417 CDK5;SLC4A2 -0.42 -5.97 -0.31 6.23e-9 Birth weight;Height; CRC cis rs6570726 0.533 rs1832374 chr6:145717752 A/G cg23711669 chr6:146136114 FBXO30 0.43 6.84 0.35 3.92e-11 Lobe attachment (rater-scored or self-reported); CRC cis rs13191362 1.000 rs35593345 chr6:163174981 G/C cg06582575 chr6:163149167 PACRG;PARK2 0.92 11.64 0.54 1.9e-26 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs4718428 0.705 rs13220977 chr7:66337648 A/T cg18252515 chr7:66147081 NA 0.52 7.45 0.38 8.08e-13 Corneal structure; CRC cis rs4481887 0.732 rs4526647 chr1:248423788 C/G cg13385794 chr1:248469461 NA 0.34 5.82 0.31 1.37e-8 Common traits (Other); CRC cis rs2019137 0.967 rs902695 chr2:113955074 G/A cg07772999 chr2:113993052 PAX8;LOC440839;LOC654433 -0.45 -6.33 -0.33 8.1e-10 Lymphocyte counts; CRC cis rs4665809 0.590 rs4665319 chr2:26424583 A/C cg25036284 chr2:26402008 FAM59B -0.56 -7.44 -0.38 8.72e-13 Gut microbiome composition (summer); CRC cis rs7258465 0.965 rs7253990 chr19:18604085 C/G cg01065977 chr19:18549689 ISYNA1 -0.41 -6.39 -0.33 5.77e-10 Breast cancer; CRC cis rs2014572 0.967 rs8111977 chr19:57759158 T/A cg12963866 chr19:57752005 ZNF805 -0.41 -6.06 -0.32 3.72e-9 Hyperactive-impulsive symptoms; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg24303698 chr19:46367351 SYMPK;FOXA3 0.44 6.29 0.33 1.02e-9 Intelligence (multi-trait analysis); CRC cis rs73206853 0.764 rs58535454 chr12:111003457 C/T cg12870014 chr12:110450643 ANKRD13A 0.81 9.34 0.46 1.45e-18 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC cis rs9463078 0.547 rs1338908 chr6:44728812 C/T cg25276700 chr6:44698697 NA 0.31 7.79 0.39 8.85e-14 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; CRC cis rs4555082 0.834 rs2816624 chr14:105733909 A/G cg10792982 chr14:105748885 BRF1 0.38 6.28 0.33 1.08e-9 Mean platelet volume;Platelet distribution width; CRC cis rs60871478 1.000 rs6460801 chr7:810506 T/C cg05535760 chr7:792225 HEATR2 0.8 10.49 0.5 2.19e-22 Cerebrospinal P-tau181p levels; CRC cis rs7727544 0.901 rs55633655 chr5:131598756 T/G cg11843238 chr5:131593191 PDLIM4 0.34 6.56 0.34 2.1e-10 Blood metabolite levels; CRC cis rs10504229 0.683 rs6980540 chr8:58127022 A/G cg02290350 chr8:58132656 NA -0.58 -8.24 -0.41 4.09e-15 Developmental language disorder (linguistic errors); CRC cis rs7666738 0.830 rs28516388 chr4:98987449 A/G cg17366294 chr4:99064904 C4orf37 0.43 7.33 0.37 1.76e-12 Colonoscopy-negative controls vs population controls; CRC cis rs919433 0.680 rs6434930 chr2:198369370 A/G cg10820045 chr2:198174542 NA 0.4 6.69 0.35 9.65e-11 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC cis rs12826942 0.876 rs17548889 chr12:42722219 C/G cg11827402 chr12:42719852 PPHLN1;ZCRB1 0.61 7.61 0.39 2.89e-13 Coronary artery disease; CRC trans rs59551326 0.512 rs2829659 chr21:26621921 C/T cg01704976 chr3:52273381 TWF2 0.52 6.01 0.31 4.85e-9 Alcohol dependence; CRC cis rs4319547 0.737 rs7964138 chr12:122950375 A/G cg05707623 chr12:122985044 ZCCHC8 -0.72 -9.33 -0.46 1.62e-18 Body mass index; CRC cis rs2243480 1.000 rs1979823 chr7:65704613 G/A cg18252515 chr7:66147081 NA 1.26 14.46 0.62 5.09e-37 Diabetic kidney disease; CRC cis rs12024301 0.557 rs16861256 chr1:183592594 C/T cg11505048 chr1:183622726 RGL1;APOBEC4 -0.74 -6.57 -0.34 1.94e-10 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs7412746 0.634 rs12562939 chr1:150951452 A/C cg15448220 chr1:150897856 SETDB1 0.55 7.8 0.4 8.21e-14 Melanoma; CRC cis rs6545883 0.560 rs11677776 chr2:61503113 T/C cg10580144 chr2:61372316 C2orf74 -0.35 -7.81 -0.4 7.63e-14 Tuberculosis; CRC cis rs8180040 0.966 rs17784882 chr3:47544003 C/A cg27129171 chr3:47204927 SETD2 -0.62 -9.56 -0.47 2.78e-19 Colorectal cancer; CRC cis rs1707322 1.000 rs1588663 chr1:46548825 G/A cg03146154 chr1:46216737 IPP -0.52 -7.18 -0.37 4.54e-12 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs11123610 0.520 rs60644898 chr2:3718646 G/A cg00999904 chr2:3704751 ALLC -0.53 -6.7 -0.35 9.16e-11 Response to inhaled corticosteroid treatment in asthma (change in FEV1); CRC cis rs12134245 0.776 rs12124682 chr1:91995542 A/G cg07090678 chr1:91966139 CDC7 0.42 6.9 0.36 2.68e-11 Breast cancer; CRC cis rs10870270 0.956 rs10430618 chr10:133748996 C/T cg08754478 chr10:133766260 PPP2R2D -0.68 -9.93 -0.48 1.73e-20 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; CRC cis rs6662572 0.737 rs72692613 chr1:46399557 A/C cg08644498 chr1:46502608 NA 0.44 6.68 0.35 1.04e-10 Blood protein levels; CRC cis rs16858210 0.647 rs67397446 chr3:183618143 C/T cg25686905 chr3:183603175 PARL -0.48 -5.94 -0.31 7.1e-9 Menopause (age at onset); CRC cis rs875971 0.862 rs11984115 chr7:65773859 C/T cg11764359 chr7:65958608 NA -0.59 -8.77 -0.44 1e-16 Aortic root size; CRC cis rs9283706 0.594 rs1366338 chr5:66344307 A/G cg11590213 chr5:66331682 MAST4 -0.43 -5.98 -0.31 5.85e-9 Coronary artery disease; CRC cis rs244731 1.000 rs244730 chr5:176539212 A/G cg06060754 chr5:176797920 RGS14 -0.53 -7.3 -0.37 2.19e-12 Urate levels in lean individuals; CRC cis rs1552244 0.554 rs2272122 chr3:10047975 C/G cg02579736 chr3:10068473 FANCD2;CIDECP 0.67 9.1 0.45 9.14e-18 Alzheimer's disease; CRC cis rs4731207 0.596 rs1026836 chr7:124683632 A/G cg23710748 chr7:124431027 NA -0.39 -6.14 -0.32 2.35e-9 Cutaneous malignant melanoma; CRC cis rs804280 0.662 rs11784693 chr8:11610674 C/T cg23972785 chr8:11611189 GATA4 -0.43 -5.97 -0.31 6.19e-9 Myopia (pathological); CRC cis rs7917772 0.503 rs7087665 chr10:104282418 T/C cg22532475 chr10:104410764 TRIM8 -0.36 -6.79 -0.35 5.16e-11 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC trans rs1499614 0.803 rs1922723 chr7:66175063 C/T cg10756647 chr7:56101905 PSPH 0.77 8.1 0.41 1.09e-14 Gout; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg13398993 chr8:66546079 ARMC1 0.45 6.46 0.34 3.7e-10 Intelligence (multi-trait analysis); CRC cis rs77216612 0.877 rs66561220 chr12:12878765 T/C cg04607235 chr12:12878440 APOLD1 -1.01 -13.78 -0.6 2.03e-34 Lymphocyte counts; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg05898629 chr16:3812688 CREBBP -0.39 -6.15 -0.32 2.31e-9 Liver disease severity in Alagille syndrome; CRC cis rs636291 0.500 rs655271 chr1:10536635 G/A cg17425144 chr1:10567563 PEX14 0.52 11.82 0.55 4.09e-27 Prostate cancer; CRC cis rs10504229 0.683 rs58438731 chr8:58134790 C/T cg02290350 chr8:58132656 NA -0.58 -8.16 -0.41 7.29e-15 Developmental language disorder (linguistic errors); CRC cis rs12594515 0.874 rs8032878 chr15:45998015 A/G cg06207120 chr15:45996521 NA 0.31 7.54 0.38 4.74e-13 Waist circumference;Weight; CRC cis rs597539 0.580 rs7935851 chr11:68731122 A/G cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.8 13.0 0.58 1.84e-31 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs6582630 0.638 rs11182428 chr12:38526387 T/C cg13010199 chr12:38710504 ALG10B -0.44 -6.33 -0.33 8.13e-10 Drug-induced liver injury (flucloxacillin); CRC cis rs9611565 0.694 rs202664 chr22:41813886 C/T cg06634786 chr22:41940651 POLR3H 0.62 7.16 0.37 5.23e-12 Vitiligo; CRC cis rs11792861 0.890 rs3087979 chr9:111781779 T/C cg05043794 chr9:111880884 C9orf5 -0.35 -6.37 -0.33 6.51e-10 Menarche (age at onset); CRC cis rs1865760 0.516 rs9393684 chr6:26075531 G/C cg16482183 chr6:26056742 HIST1H1C 0.5 7.25 0.37 3.03e-12 Height; CRC cis rs6714710 0.603 rs953320 chr2:98606770 T/C cg26665480 chr2:98280029 ACTR1B 0.56 7.57 0.38 3.91e-13 Posterior cortical atrophy and Alzheimer's disease; CRC cis rs9308731 0.583 rs7596789 chr2:111932616 G/A cg04202892 chr2:111875749 ACOXL 0.42 6.78 0.35 5.58e-11 Chronic lymphocytic leukemia; CRC cis rs10504229 1.000 rs67388517 chr8:58176617 C/A cg02290350 chr8:58132656 NA -0.42 -5.96 -0.31 6.62e-9 Developmental language disorder (linguistic errors); CRC cis rs9905704 0.756 rs302860 chr17:56695008 C/A cg12560992 chr17:57184187 TRIM37 0.57 8.3 0.42 2.69e-15 Testicular germ cell tumor; CRC cis rs2976388 0.609 rs2164308 chr8:143785659 A/G cg12516270 chr8:143859308 LYNX1 -0.43 -7.52 -0.38 5.35e-13 Urinary tract infection frequency; CRC cis rs7089973 0.836 rs12765350 chr10:116635305 G/A cg23260525 chr10:116636907 FAM160B1 0.32 6.81 0.35 4.75e-11 Bipolar disorder or attention deficit hyperactivity disorder; CRC cis rs13418410 0.539 rs11677468 chr2:33839053 T/C cg04131969 chr2:33951647 MYADML -0.65 -9.74 -0.47 7.33e-20 Non-response to antidepressants and depression; CRC cis rs9311474 0.508 rs12637627 chr3:52619962 G/T cg18404041 chr3:52824283 ITIH1 -0.4 -8.49 -0.42 7.42e-16 Electroencephalogram traits; CRC trans rs747782 0.528 rs11039669 chr11:48328818 C/T cg15704280 chr7:45808275 SEPT13 0.68 6.52 0.34 2.58e-10 Intraocular pressure; CRC trans rs875971 0.660 rs2191268 chr7:66110224 C/T cg00024722 chr15:32163260 NA -0.39 -6.14 -0.32 2.39e-9 Aortic root size; CRC cis rs9463078 0.715 rs9395049 chr6:44792718 C/T cg25276700 chr6:44698697 NA 0.25 6.12 0.32 2.61e-9 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; CRC cis rs2040771 0.770 rs9605962 chr22:19233615 C/T cg02655711 chr22:19163373 SLC25A1 0.51 8.38 0.42 1.6e-15 Metabolite levels (small molecules and protein measures); CRC cis rs4819052 0.724 rs9753987 chr21:46661389 C/T cg02159808 chr21:46707872 POFUT2;LOC642852 0.49 6.41 0.33 5.19e-10 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg03769523 chr10:104613934 C10orf32 0.43 6.02 0.31 4.59e-9 Response to antipsychotic treatment; CRC cis rs7224685 0.501 rs781853 chr17:3953083 T/C cg11204139 chr17:3907470 NA 0.76 14.24 0.62 3.65e-36 Type 2 diabetes; CRC cis rs1448094 0.817 rs61929421 chr12:86342330 T/C cg02569458 chr12:86230093 RASSF9 0.47 7.98 0.4 2.53e-14 Major depressive disorder; CRC cis rs875971 0.929 rs778682 chr7:65837934 A/G cg18912574 chr7:65842487 NCRNA00174 0.36 6.18 0.32 1.88e-9 Aortic root size; CRC cis rs4889855 0.505 rs8076974 chr17:78621817 G/A cg16591659 chr17:78472290 NA -0.41 -6.09 -0.32 3.18e-9 Fractional excretion of uric acid; CRC cis rs10512697 0.803 rs13189635 chr5:3575571 T/A cg19473799 chr5:3511975 NA -0.72 -5.67 -0.3 3.12e-8 Immune response to smallpox vaccine (IL-6); CRC cis rs853679 0.546 rs200953 chr6:27837267 T/C cg08798685 chr6:27730294 NA -0.63 -6.13 -0.32 2.57e-9 Depression; CRC cis rs11679072 1.000 rs7573739 chr2:240448123 G/A cg03276489 chr2:240449683 NA -0.93 -9.41 -0.46 8.71e-19 Blood pressure (smoking interaction); CRC cis rs1552244 1.000 rs58275763 chr3:10143274 C/T cg16606324 chr3:10149918 C3orf24 0.74 10.05 0.48 6.72e-21 Alzheimer's disease; CRC cis rs10744422 1.000 rs937766 chr12:123331094 G/T cg25930673 chr12:123319894 HIP1R -0.6 -6.32 -0.33 8.63e-10 Schizophrenia; CRC cis rs3824867 0.920 rs7105122 chr11:47449544 A/G cg05585544 chr11:47624801 NA -0.39 -6.06 -0.32 3.66e-9 Mean corpuscular hemoglobin; CRC cis rs780096 0.506 rs2303369 chr2:27715416 C/T cg02592271 chr2:27665507 KRTCAP3 -0.27 -5.94 -0.31 7.17e-9 Total body bone mineral density; CRC cis rs875971 0.862 rs6945775 chr7:65968974 G/A cg12463550 chr7:65579703 CRCP 0.49 6.84 0.35 3.89e-11 Aortic root size; CRC cis rs1215050 0.791 rs2695472 chr4:98855127 T/C cg05340658 chr4:99064831 C4orf37 -0.48 -7.21 -0.37 3.82e-12 Waist-to-hip ratio adjusted for body mass index; CRC cis rs6460942 0.591 rs75804221 chr7:12364319 C/T cg20607287 chr7:12443886 VWDE -0.53 -5.86 -0.31 1.1e-8 Coronary artery disease; CRC cis rs8078723 0.714 rs2241245 chr17:38151014 C/T cg17467752 chr17:38218738 THRA -0.57 -9.13 -0.45 6.89e-18 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); CRC cis rs9322193 1.000 rs58189451 chr6:149921388 G/A cg05861140 chr6:150128134 PCMT1 -0.39 -6.11 -0.32 2.86e-9 Lung cancer; CRC cis rs7666738 0.830 rs6832568 chr4:98994061 G/A cg17366294 chr4:99064904 C4orf37 0.44 7.39 0.38 1.19e-12 Colonoscopy-negative controls vs population controls; CRC cis rs3857067 0.773 rs10023115 chr4:95095502 G/A cg11021082 chr4:95130006 SMARCAD1 -0.49 -7.67 -0.39 1.95e-13 QT interval; CRC cis rs17125944 0.542 rs75723366 chr14:53256882 T/C cg00686598 chr14:53173677 PSMC6 1.2 11.3 0.53 3.17e-25 Alzheimer's disease (late onset); CRC cis rs117623576 0.941 rs211423 chr10:32398777 A/G cg03047570 chr10:32398778 NA 0.81 8.88 0.44 4.36e-17 Anti-saccade response; CRC trans rs2243480 1.000 rs1723270 chr7:65469830 T/G cg10756647 chr7:56101905 PSPH 0.71 7.67 0.39 1.92e-13 Diabetic kidney disease; CRC cis rs5769765 0.908 rs138867 chr22:50207703 A/G cg02269571 chr22:50332266 NA 0.62 8.58 0.43 3.78e-16 Schizophrenia; CRC cis rs7613875 0.580 rs11709503 chr3:49991167 G/T cg24308560 chr3:49941425 MST1R -0.43 -6.67 -0.35 1.09e-10 Body mass index; CRC trans rs12495832 0.778 rs4681395 chr3:147889283 T/C cg10221266 chr7:153579447 NA 0.57 6.14 0.32 2.44e-9 Chin dimples; CRC cis rs4665809 0.590 rs35746418 chr2:26455002 C/G cg04944784 chr2:26401820 FAM59B 0.83 10.74 0.51 2.96e-23 Gut microbiome composition (summer); CRC cis rs9926296 0.568 rs4420527 chr16:89814188 C/T cg21285383 chr16:89894308 SPIRE2 -0.34 -5.67 -0.3 3.19e-8 Vitiligo; CRC cis rs6740322 0.895 rs6544643 chr2:43560072 C/T cg06169590 chr2:43455088 ZFP36L2;LOC100129726 -0.75 -9.37 -0.46 1.22e-18 Coronary artery disease; CRC trans rs6011368 0.792 rs6512309 chr20:62892584 A/G cg13869341 chr1:15865 WASH5P 0.41 6.04 0.32 4.19e-9 Clozapine-induced cytotoxicity; CRC cis rs7639513 0.767 rs7648488 chr3:12708946 T/C cg23032965 chr3:12705835 RAF1 0.64 9.84 0.48 3.37e-20 Itch intensity from mosquito bite; CRC cis rs643506 1.000 rs643506 chr11:111636627 T/G cg09085632 chr11:111637200 PPP2R1B 0.5 6.46 0.34 3.83e-10 Breast cancer; CRC cis rs4563143 0.675 rs112383987 chr19:29261081 C/T cg14983838 chr19:29218262 NA 0.46 6.76 0.35 6.47e-11 Methadone dose in opioid dependence; CRC cis rs2463822 1.000 rs11231050 chr11:62131660 C/G cg06239285 chr11:62104954 ASRGL1 -0.97 -10.57 -0.5 1.1e-22 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs1568889 1.000 rs12797689 chr11:28076042 C/A cg06544937 chr11:28130018 METT5D1;KIF18A 0.76 9.78 0.47 5.38e-20 Bipolar disorder; CRC trans rs596169 0.655 rs12087006 chr1:219203397 T/C cg09853702 chr12:47665230 NA 0.82 6.39 0.33 5.63e-10 Intraocular pressure; CRC cis rs6681460 1.000 rs2872078 chr1:67127367 C/A cg02459107 chr1:67143332 SGIP1 0.45 7.51 0.38 5.73e-13 Presence of antiphospholipid antibodies; CRC cis rs7772486 0.658 rs9403737 chr6:145962193 G/T cg05347473 chr6:146136440 FBXO30 0.38 5.71 0.3 2.52e-8 Lobe attachment (rater-scored or self-reported); CRC cis rs7098414 0.511 rs4934134 chr10:82160582 C/T cg00277334 chr10:82204260 NA -0.5 -8.17 -0.41 6.89e-15 Post bronchodilator FEV1; CRC trans rs7395662 0.504 rs2019666 chr11:48437729 C/T cg03929089 chr4:120376271 NA -0.46 -6.6 -0.34 1.62e-10 HDL cholesterol; CRC cis rs7809950 1.000 rs4727684 chr7:107226470 C/T cg23024343 chr7:107201750 COG5 -0.63 -8.98 -0.44 2.1e-17 Coronary artery disease; CRC cis rs478304 0.514 rs75601653 chr11:65483370 C/G cg27068330 chr11:65405492 SIPA1 -0.77 -11.6 -0.54 2.52e-26 Acne (severe); CRC cis rs7726839 0.540 rs72703083 chr5:595365 C/T cg16447950 chr5:562315 NA -0.73 -9.65 -0.47 1.41e-19 Obesity-related traits; CRC cis rs2204008 0.522 rs117743143 chr12:38030824 C/T cg13010199 chr12:38710504 ALG10B 0.49 7.19 0.37 4.52e-12 Bladder cancer; CRC cis rs13256369 1.000 rs873064 chr8:8572380 G/A cg06671706 chr8:8559999 CLDN23 0.56 8.13 0.41 8.9e-15 Obesity-related traits; CRC cis rs875971 0.862 rs9791712 chr7:66105163 C/G cg00343986 chr7:65444356 GUSB -0.45 -6.24 -0.33 1.32e-9 Aortic root size; CRC cis rs6598955 0.671 rs11247896 chr1:26600483 A/G cg04990556 chr1:26633338 UBXN11 0.53 5.73 0.3 2.23e-8 Obesity-related traits; CRC cis rs17376456 0.825 rs35426871 chr5:93291613 C/T cg21475434 chr5:93447410 FAM172A 0.81 7.7 0.39 1.65e-13 Diabetic retinopathy; CRC cis rs4862307 0.514 rs7696176 chr4:185014390 A/G cg06737308 chr4:185021514 ENPP6 0.65 12.59 0.57 6.41e-30 Serum dimethylarginine levels (asymmetric/symetric ratio); CRC trans rs9329221 0.537 rs13282106 chr8:9981900 G/T cg06636001 chr8:8085503 FLJ10661 0.44 6.42 0.33 4.69e-10 Neuroticism; CRC cis rs9911578 1.000 rs2079703 chr17:56603978 G/A cg05425664 chr17:57184151 TRIM37 0.51 8.14 0.41 8.43e-15 Intelligence (multi-trait analysis); CRC cis rs1267303 0.563 rs2486163 chr1:47004680 T/C cg08533674 chr1:46993347 NA -0.72 -9.39 -0.46 1.02e-18 Monobrow; CRC cis rs75920871 0.528 rs682048 chr11:116828320 T/G cg01368799 chr11:117014884 PAFAH1B2 -0.41 -5.84 -0.31 1.25e-8 Subjective well-being; CRC trans rs4276421 0.869 rs62369107 chr5:45552765 G/T cg04793272 chr11:119020941 ABCG4 -0.37 -6.09 -0.32 3.14e-9 P wave duration; CRC cis rs2730260 0.800 rs73169216 chr7:158834662 G/A cg02254261 chr7:158964346 NA -0.57 -6.32 -0.33 8.37e-10 Myopia (pathological); CRC cis rs3771570 1.000 rs4675811 chr2:242402062 A/T cg21155796 chr2:242212141 HDLBP 0.54 6.45 0.34 4e-10 Prostate cancer; CRC cis rs10504229 1.000 rs73609760 chr8:58192170 A/G cg02290350 chr8:58132656 NA -0.41 -5.66 -0.3 3.21e-8 Developmental language disorder (linguistic errors); CRC trans rs7615952 0.546 rs2922194 chr3:125332263 G/A cg02007433 chr3:129722099 NA -0.51 -6.13 -0.32 2.48e-9 Blood pressure (smoking interaction); CRC cis rs6089584 0.888 rs6061966 chr20:60607936 C/G cg12751644 chr20:60527061 NA -0.38 -5.89 -0.31 9.56e-9 Body mass index; CRC cis rs1008375 1.000 rs1558377 chr4:17650758 A/G cg16339924 chr4:17578868 LAP3 0.55 7.28 0.37 2.41e-12 Parasitemia in Tripanosoma cruzi seropositivity; CRC trans rs6430538 0.646 rs6734820 chr2:135536808 A/G cg10733145 chr11:60673895 PRPF19 0.37 6.12 0.32 2.59e-9 Parkinson's disease; CRC cis rs2019137 0.868 rs3748916 chr2:113984033 C/T cg07772999 chr2:113993052 PAX8;LOC440839;LOC654433 -0.45 -6.48 -0.34 3.28e-10 Lymphocyte counts; CRC cis rs4237845 1.000 rs4237845 chr12:58302436 A/G cg02175503 chr12:58329896 NA -0.61 -9.3 -0.46 2e-18 Intelligence (multi-trait analysis); CRC cis rs2279817 1.000 rs2279816 chr1:18021867 T/C cg21791023 chr1:18019539 ARHGEF10L 0.5 6.28 0.33 1.06e-9 Neuroticism; CRC trans rs7618501 1.000 rs6802890 chr3:49832261 A/G cg21665057 chr3:196295764 WDR53;FBXO45 0.83 15.34 0.65 1.89e-40 Intelligence (multi-trait analysis); CRC trans rs2235573 0.551 rs139892 chr22:38388203 C/T cg19894588 chr14:64061835 NA 0.54 7.46 0.38 7.68e-13 Glioblastoma;Glioma; CRC cis rs4926298 1.000 rs4926298 chr19:13153035 C/T cg06417478 chr19:12876846 HOOK2 -0.42 -5.65 -0.3 3.43e-8 Bipolar disorder; CRC trans rs6601327 0.898 rs1458942 chr8:9406602 C/T cg06636001 chr8:8085503 FLJ10661 -0.46 -6.48 -0.34 3.45e-10 Multiple myeloma (hyperdiploidy); CRC cis rs7523050 0.643 rs35050241 chr1:109404876 T/C cg08274380 chr1:109419600 GPSM2 0.86 6.9 0.36 2.74e-11 Fat distribution (HIV); CRC cis rs9487051 0.676 rs9398193 chr6:109593134 G/T cg21918786 chr6:109611834 NA -0.41 -7.17 -0.37 4.84e-12 Reticulocyte fraction of red cells; CRC cis rs11785400 0.731 rs9720504 chr8:143725502 T/C cg10596483 chr8:143751796 JRK 0.47 6.37 0.33 6.37e-10 Schizophrenia; CRC cis rs6502050 0.835 rs62078305 chr17:80085326 G/A cg22110888 chr17:80059540 CCDC57 -0.41 -6.39 -0.33 5.58e-10 Life satisfaction; CRC trans rs7615952 0.546 rs111812401 chr3:125361495 G/A cg00769240 chr8:12517080 NA -0.68 -7.78 -0.39 9.14e-14 Blood pressure (smoking interaction); CRC cis rs990171 0.837 rs1568681 chr2:103014696 C/T cg03938978 chr2:103052716 IL18RAP 0.47 5.94 0.31 7.25e-9 Lymphocyte counts; CRC cis rs6951245 1.000 rs78185558 chr7:1090183 G/C cg24642844 chr7:1081250 C7orf50 -0.74 -9.19 -0.45 4.55e-18 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs4563143 0.514 rs55727361 chr19:29300415 A/T cg12756686 chr19:29218302 NA 0.64 8.77 0.44 9.78e-17 Methadone dose in opioid dependence; CRC cis rs9467711 0.606 rs9393706 chr6:26361500 G/A cg14345882 chr6:26364793 BTN3A2 0.64 5.63 0.3 3.85e-8 Autism spectrum disorder or schizophrenia; CRC cis rs6502050 0.764 rs35713597 chr17:80119016 C/G cg19223190 chr17:80058835 NA 0.39 6.23 0.32 1.43e-9 Life satisfaction; CRC cis rs2635047 0.756 rs34939493 chr18:44795621 G/T cg19077165 chr18:44547161 KATNAL2 -0.38 -5.93 -0.31 7.52e-9 Educational attainment; CRC cis rs6594713 0.819 rs10061462 chr5:112726205 A/T cg12552261 chr5:112820674 MCC 0.41 5.65 0.3 3.42e-8 Brain cytoarchitecture; CRC cis rs2204008 0.805 rs10881112 chr12:37956611 G/A cg26384229 chr12:38710491 ALG10B -0.62 -9.28 -0.46 2.29e-18 Bladder cancer; CRC cis rs3096299 0.503 rs9925045 chr16:89556476 T/C cg00750074 chr16:89608354 SPG7 -0.48 -7.14 -0.37 6.07e-12 Multiple myeloma (IgH translocation); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg24311251 chr13:44453387 CCDC122;C13orf31 0.37 5.97 0.31 6.31e-9 Liver disease severity in Alagille syndrome; CRC trans rs57221529 0.766 rs72703070 chr5:590458 T/C cg25482853 chr8:67687455 SGK3 1.19 14.38 0.62 1e-36 Lung disease severity in cystic fibrosis; CRC cis rs12143943 0.738 rs11240750 chr1:204459786 T/C cg17419461 chr1:204415978 PIK3C2B 0.38 6.02 0.31 4.75e-9 Cognitive performance; CRC cis rs2268241 0.877 rs17887186 chr21:34779202 G/A cg14850771 chr21:34775459 IFNGR2 0.77 9.64 0.47 1.6e-19 Obesity-related traits; CRC cis rs3772130 1.000 rs2070180 chr3:121351338 A/G cg20356878 chr3:121714668 ILDR1 -0.48 -7.5 -0.38 6.05e-13 Cognitive performance; CRC cis rs4665809 0.941 rs41285975 chr2:26351144 T/C cg25036284 chr2:26402008 FAM59B -0.46 -5.97 -0.31 6e-9 Gut microbiome composition (summer); CRC trans rs7647973 0.667 rs4241405 chr3:49642027 C/T cg21665057 chr3:196295764 WDR53;FBXO45 -0.65 -6.96 -0.36 1.83e-11 Menarche (age at onset); CRC cis rs734999 0.545 rs4474198 chr1:2553758 C/T cg18854424 chr1:2615690 NA 0.48 9.69 0.47 1.06e-19 Ulcerative colitis; CRC cis rs4481887 1.000 rs4489592 chr1:248470697 A/T cg00666640 chr1:248458726 OR2T12 0.54 9.42 0.46 8.4e-19 Common traits (Other); CRC cis rs9916302 0.861 rs593480 chr17:37453780 A/C cg03013999 chr17:37608204 MED1 -0.48 -7.43 -0.38 9.53e-13 Glomerular filtration rate (creatinine); CRC trans rs2243480 1.000 rs4718334 chr7:65789454 G/A cg10756647 chr7:56101905 PSPH -0.79 -8.26 -0.41 3.68e-15 Diabetic kidney disease; CRC cis rs8060686 0.925 rs9928531 chr16:67833171 T/C cg26727032 chr16:67993705 SLC12A4 -0.75 -11.92 -0.55 1.73e-27 HDL cholesterol;Metabolic syndrome; CRC cis rs13082711 0.519 rs13091109 chr3:27229125 G/A cg02860705 chr3:27208620 NA 0.72 9.92 0.48 1.85e-20 Systolic blood pressure;Diastolic blood pressure;Blood pressure; CRC cis rs13031619 0.660 rs35668314 chr2:3702673 C/T cg00999904 chr2:3704751 ALLC -0.79 -9.75 -0.47 6.72e-20 Response to inhaled corticosteroid treatment in asthma (change in FEV1); CRC cis rs7223966 1.000 rs992416 chr17:61745905 A/C cg05941027 chr17:61774174 LIMD2 0.37 6.71 0.35 8.59e-11 Hip circumference adjusted for BMI;Body mass index; CRC cis rs9549367 0.789 rs34448227 chr13:113884754 A/C cg18105134 chr13:113819100 PROZ -0.72 -10.78 -0.51 2.1e-23 Platelet distribution width; CRC cis rs8050755 0.649 rs1800720 chr16:2105400 C/T cg04515572 chr16:2107413 TSC2 -0.69 -7.15 -0.37 5.65e-12 Major depressive disorder; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg18238491 chr18:47901440 SKA1 0.46 7.01 0.36 1.39e-11 Liver disease severity in Alagille syndrome; CRC cis rs7259376 0.936 rs6511350 chr19:22594697 A/G cg02657401 chr19:22469223 NA 0.32 7.0 0.36 1.41e-11 Menopause (age at onset); CRC cis rs1124376 1.000 rs4417886 chr3:20108511 C/T cg05072819 chr3:20081367 KAT2B 0.56 6.65 0.34 1.2e-10 Bipolar disorder and schizophrenia; CRC cis rs11997175 0.646 rs2006792 chr8:33694423 G/A cg04338863 chr8:33670619 NA 0.43 6.76 0.35 6.28e-11 Body mass index; CRC cis rs13118159 0.836 rs2293630 chr4:1342521 G/A cg16405210 chr4:1374714 KIAA1530 -0.47 -6.55 -0.34 2.28e-10 Longevity; CRC cis rs364477 0.721 rs279876 chr9:996439 G/T cg13952963 chr9:998547 NA -0.59 -6.87 -0.35 3.26e-11 Major depressive disorder; CRC cis rs7666738 0.715 rs116787789 chr4:98718720 G/A cg05340658 chr4:99064831 C4orf37 0.54 8.0 0.4 2.21e-14 Colonoscopy-negative controls vs population controls; CRC cis rs1580019 0.961 rs1868776 chr7:32494435 G/T cg06627557 chr7:32535165 LSM5;AVL9 -0.71 -11.15 -0.52 1.06e-24 Cognitive ability; CRC cis rs7264396 0.677 rs6060553 chr20:34267386 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.57 -9.16 -0.45 5.76e-18 Total cholesterol levels; CRC cis rs7552404 0.727 rs5745433 chr1:76333163 T/G cg03433033 chr1:76189801 ACADM 0.67 8.69 0.43 1.78e-16 Blood metabolite levels;Acylcarnitine levels; CRC cis rs2032447 0.670 rs198850 chr6:26104670 A/C cg12310025 chr6:25882481 NA 0.45 6.32 0.33 8.7e-10 Intelligence (multi-trait analysis); CRC cis rs6743376 0.556 rs2441375 chr2:113817268 T/C cg09040174 chr2:113837401 NA 0.44 6.42 0.33 4.87e-10 Inflammatory biomarkers; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg05556477 chr5:131705319 SLC22A5 0.42 5.97 0.31 6.11e-9 Intelligence (multi-trait analysis); CRC cis rs3806843 0.900 rs2262576 chr5:140135536 T/C cg16607685 chr5:140181889 PCDHA2;PCDHA1;PCDHA3 0.26 5.99 0.31 5.45e-9 Depressive symptoms (multi-trait analysis); CRC cis rs8180040 0.903 rs11130124 chr3:47292183 T/C cg02527881 chr3:46936655 PTH1R -0.38 -6.95 -0.36 1.97e-11 Colorectal cancer; CRC cis rs7615952 0.641 rs4490307 chr3:125712676 T/G cg02807482 chr3:125708958 NA -0.43 -5.99 -0.31 5.35e-9 Blood pressure (smoking interaction); CRC cis rs7131987 0.650 rs12366527 chr12:29474256 C/G cg09582351 chr12:29534625 ERGIC2 -0.34 -7.19 -0.37 4.36e-12 QT interval; CRC cis rs2522056 1.000 rs1003533 chr5:131755651 C/T cg20512303 chr5:131592959 PDLIM4 -0.36 -5.66 -0.3 3.22e-8 Lymphocyte counts;Fibrinogen; CRC cis rs2412459 1.000 rs6492925 chr15:40304170 T/G cg01081584 chr15:40268610 EIF2AK4 -0.65 -6.08 -0.32 3.28e-9 Response to haloperidol in psychosis; CRC cis rs4665809 1.000 rs2289022 chr2:26350136 G/T cg22920501 chr2:26401640 FAM59B -0.52 -7.15 -0.37 5.68e-12 Gut microbiome composition (summer); CRC cis rs8177253 0.665 rs7646118 chr3:133450039 C/T cg16262614 chr3:133464971 TF 0.4 7.1 0.36 7.79e-12 Iron status biomarkers; CRC cis rs1401999 1.000 rs6767013 chr3:183680102 G/A cg20387954 chr3:183756860 HTR3D 0.45 7.61 0.39 2.97e-13 Anterior chamber depth; CRC cis rs4713118 0.869 rs9348775 chr6:27695329 C/T cg19041857 chr6:27730383 NA -0.45 -6.47 -0.34 3.65e-10 Parkinson's disease; CRC cis rs41271473 0.526 rs12136157 chr1:228703236 T/C cg16512390 chr1:228756714 NA 0.64 6.72 0.35 8.18e-11 Chronic lymphocytic leukemia; CRC cis rs2073300 0.609 rs6132606 chr20:23367453 G/A cg12062639 chr20:23401060 NAPB 0.74 6.78 0.35 5.43e-11 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs7589728 1.000 rs75181745 chr2:88520408 C/T cg07952391 chr2:88470173 THNSL2 0.66 6.69 0.35 9.43e-11 Plasma clusterin levels; CRC cis rs6088580 0.668 rs1205340 chr20:32923871 G/A cg24642439 chr20:33292090 TP53INP2 -0.42 -6.92 -0.36 2.41e-11 Glomerular filtration rate (creatinine); CRC cis rs6460942 1.000 rs7808819 chr7:12297440 C/T cg20607287 chr7:12443886 VWDE -0.6 -6.22 -0.32 1.53e-9 Coronary artery disease; CRC trans rs17685 0.712 rs10235738 chr7:75773460 G/A cg19862616 chr7:65841803 NCRNA00174 0.95 17.19 0.69 9.99e-48 Coffee consumption;Coffee consumption (cups per day); CRC cis rs12701220 0.894 rs12539012 chr7:1052133 G/A cg26240231 chr7:1148101 C7orf50 -0.43 -5.73 -0.3 2.26e-8 Bronchopulmonary dysplasia; CRC cis rs1150688 1 rs1150688 chr6:28162780 T/C cg23161317 chr6:28129485 ZNF389 0.4 6.06 0.32 3.64e-9 Autism spectrum disorder or schizophrenia; CRC cis rs875971 0.862 rs1968126 chr7:66057004 A/G cg18876405 chr7:65276391 NA -0.53 -8.62 -0.43 2.91e-16 Aortic root size; CRC cis rs4665809 0.590 rs2384361 chr2:26452209 T/C cg04944784 chr2:26401820 FAM59B -0.84 -10.98 -0.52 4.25e-24 Gut microbiome composition (summer); CRC cis rs2276314 0.857 rs9960670 chr18:33577712 A/G cg05985134 chr18:33552581 C18orf21 0.47 6.16 0.32 2.15e-9 Endometriosis;Drug-induced torsades de pointes; CRC cis rs875971 0.545 rs1547529 chr7:65723846 T/C cg05627663 chr7:65219948 SNORA22;CCT6P1 0.58 7.42 0.38 1.01e-12 Aortic root size; CRC cis rs6500602 0.727 rs1477123 chr16:4560627 T/A cg08645402 chr16:4508243 NA 0.54 8.14 0.41 8.44e-15 Schizophrenia; CRC cis rs6938 0.618 rs11638130 chr15:75183935 G/A cg09165964 chr15:75287851 SCAMP5 0.58 9.16 0.45 5.8e-18 Breast cancer; CRC cis rs9487051 0.872 rs9487042 chr6:109610443 T/G cg21918786 chr6:109611834 NA -0.45 -8.32 -0.42 2.32e-15 Reticulocyte fraction of red cells; CRC cis rs7789940 1.000 rs2072435 chr7:75959188 G/A cg10167463 chr7:75959203 YWHAG -0.77 -11.27 -0.53 3.99e-25 Multiple sclerosis; CRC cis rs365302 0.953 rs389041 chr6:159646853 G/A cg14500486 chr6:159655392 FNDC1 0.43 6.63 0.34 1.41e-10 Coronary heart disease; CRC cis rs6694672 0.867 rs4915307 chr1:197048608 T/C cg13682187 chr1:196946512 CFHR5 0.47 7.35 0.38 1.56e-12 Asthma; CRC cis rs1552244 0.882 rs68080705 chr3:10025743 C/T cg02579736 chr3:10068473 FANCD2;CIDECP 0.92 11.7 0.54 1.09e-26 Alzheimer's disease; CRC cis rs6840360 1.000 rs1105535 chr4:152605170 A/G cg09659197 chr4:152720779 NA 0.47 9.97 0.48 1.24e-20 Intelligence (multi-trait analysis); CRC cis rs4604732 0.631 rs80319072 chr1:247626835 G/A cg12758973 chr1:247694275 LOC148824;OR2C3 0.42 6.14 0.32 2.32e-9 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CRC cis rs2976388 0.566 rs4736373 chr8:143792357 G/C cg04969067 chr8:143858791 LYNX1 -0.4 -6.07 -0.32 3.45e-9 Urinary tract infection frequency; CRC cis rs12348691 0.503 rs7023267 chr9:100603935 G/A cg13688889 chr9:100608707 NA -0.45 -5.79 -0.3 1.61e-8 Alopecia areata; CRC cis rs1577917 0.740 rs2758842 chr6:86308731 A/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.57 -7.94 -0.4 3.24e-14 Response to antipsychotic treatment; CRC cis rs4474465 0.833 rs10793317 chr11:78212011 G/A cg27205649 chr11:78285834 NARS2 0.47 5.73 0.3 2.31e-8 Alzheimer's disease (survival time); CRC trans rs1814175 0.781 rs12286395 chr11:49954062 C/G cg15704280 chr7:45808275 SEPT13 -0.97 -18.82 -0.72 3.98e-54 Height; CRC cis rs748404 0.660 rs2249952 chr15:43720533 G/C cg15269541 chr15:43626905 ADAL -0.36 -5.64 -0.3 3.7e-8 Lung cancer; CRC trans rs7613875 0.537 rs6446195 chr3:50070853 A/G cg21665057 chr3:196295764 WDR53;FBXO45 -0.44 -6.39 -0.33 5.6e-10 Body mass index; CRC cis rs2257205 0.667 rs9893027 chr17:56653448 G/C cg25885038 chr17:56607967 SEPT4 -0.56 -6.17 -0.32 2.04e-9 Pancreatic cancer; CRC cis rs6570726 0.791 rs365747 chr6:145866784 C/T cg05347473 chr6:146136440 FBXO30 0.39 5.99 0.31 5.54e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs11030122 0.702 rs10835407 chr11:3993231 C/T cg18678763 chr11:4115507 RRM1 0.51 8.41 0.42 1.27e-15 Mean platelet volume;Platelet distribution width; CRC cis rs1448094 0.533 rs4412812 chr12:86151238 G/A cg19622623 chr12:86230825 RASSF9 0.4 6.32 0.33 8.38e-10 Major depressive disorder; CRC cis rs76878669 0.538 rs1546358 chr11:66175261 G/C cg24851651 chr11:66362959 CCS -0.38 -6.41 -0.33 5.06e-10 Educational attainment (years of education); CRC cis rs7666738 0.753 rs7698541 chr4:98986351 T/A cg17366294 chr4:99064904 C4orf37 0.43 7.33 0.37 1.76e-12 Colonoscopy-negative controls vs population controls; CRC cis rs2979489 0.891 rs2979504 chr8:30386641 C/T cg26383811 chr8:30366931 RBPMS -0.71 -10.73 -0.51 3.2e-23 Mean corpuscular hemoglobin;Plateletcrit;Neutrophil count;Granulocyte count;Sum basophil neutrophil counts;Mean corpuscular volume;Myeloid white cell count;Sum neutrophil eosinophil counts; CRC cis rs763014 0.966 rs7185390 chr16:666382 A/G cg07343612 chr16:622815 PIGQ -0.81 -13.72 -0.6 3.49e-34 Height; CRC cis rs6860806 0.695 rs11952099 chr5:131576772 A/G cg04518342 chr5:131593106 PDLIM4 0.47 8.82 0.44 6.79e-17 Breast cancer; CRC trans rs8002861 0.935 rs9525865 chr13:44459647 A/T cg17145862 chr1:211918768 LPGAT1 0.79 16.07 0.66 2.57e-43 Leprosy; CRC cis rs2249694 0.959 rs4129223 chr10:135403948 A/G cg20169779 chr10:135381914 SYCE1 -0.63 -10.64 -0.51 6.49e-23 Obesity-related traits; CRC cis rs919433 0.680 rs3792159 chr2:198403697 A/G cg10820045 chr2:198174542 NA -0.38 -6.29 -0.33 1.03e-9 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC cis rs7932354 0.583 rs7943866 chr11:46881954 C/T cg19486271 chr11:47235900 DDB2 -0.42 -6.34 -0.33 7.49e-10 Bone mineral density (hip);Bone mineral density; CRC cis rs8177253 0.665 rs7646118 chr3:133450039 C/T cg17775713 chr3:133465469 TF 0.33 5.87 0.31 1.07e-8 Iron status biomarkers; CRC cis rs9381040 0.674 rs4711657 chr6:41162715 G/A cg20398880 chr6:41068722 NFYA;LOC221442 -0.39 -5.93 -0.31 7.49e-9 Alzheimer's disease (late onset); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg22962396 chr19:3762602 MRPL54;APBA3 0.46 6.35 0.33 7.13e-10 Response to antipsychotic treatment; CRC cis rs10924970 0.649 rs12748629 chr1:235425959 T/C cg09010748 chr1:235293032 TOMM20 -0.41 -5.66 -0.3 3.37e-8 Asthma; CRC cis rs9486715 1.000 rs9386670 chr6:97060688 C/A cg18709589 chr6:96969512 KIAA0776 -0.51 -7.42 -0.38 1.02e-12 Headache; CRC cis rs62408225 0.962 rs1604830 chr6:90969221 T/C cg06866423 chr6:90926672 BACH2 0.5 8.15 0.41 7.56e-15 Eosinophil counts;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC trans rs66887589 0.777 rs1814815 chr4:120258091 C/T cg25214090 chr10:38739885 LOC399744 0.39 6.0 0.31 5.15e-9 Diastolic blood pressure; CRC cis rs262150 0.704 rs2730236 chr7:158765543 C/T cg19418458 chr7:158789849 NA -0.49 -8.23 -0.41 4.54e-15 Facial morphology (factor 20); CRC cis rs875971 1.000 rs12698523 chr7:65968113 C/G cg00343986 chr7:65444356 GUSB 0.44 6.47 0.34 3.56e-10 Aortic root size; CRC trans rs8035957 1.000 rs4924273 chr15:38846738 C/G cg23355997 chr17:7154831 DULLARD;C17orf81 -0.54 -6.53 -0.34 2.49e-10 Type 1 diabetes; CRC trans rs10435719 0.902 rs4840599 chr8:11805380 C/T cg06636001 chr8:8085503 FLJ10661 -0.48 -7.42 -0.38 9.86e-13 C-reactive protein levels or triglyceride levels (pleiotropy); CRC cis rs3791556 0.853 rs35245395 chr2:240107661 C/T cg03281426 chr2:240109471 HDAC4 0.72 9.25 0.45 2.88e-18 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC trans rs10982213 0.830 rs2274163 chr9:117188714 C/T cg02290575 chr7:100964799 RABL5 0.38 6.3 0.33 9.74e-10 Interleukin-6 levels; CRC cis rs6502050 0.835 rs8065037 chr17:80158966 T/G cg09264619 chr17:80180166 NA -0.36 -6.1 -0.32 3e-9 Life satisfaction; CRC cis rs9322193 0.923 rs12211511 chr6:150066342 G/C cg13206674 chr6:150067644 NUP43 0.57 8.29 0.42 3.02e-15 Lung cancer; CRC cis rs1005224 0.889 rs12717566 chr14:76147507 C/T cg04684003 chr14:76127793 TTLL5;C14orf1 -0.49 -7.11 -0.36 7.28e-12 Large artery stroke; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg14885145 chr10:104262292 SUFU;ACTR1A 0.42 5.96 0.31 6.41e-9 Response to antipsychotic treatment; CRC cis rs823143 0.570 rs823084 chr1:205798313 G/T cg07157834 chr1:205819609 PM20D1 0.58 8.68 0.43 1.91e-16 Monocyte percentage of white cells; CRC trans rs7873102 0.702 rs7028020 chr9:38007747 C/T cg22708290 chr12:56368226 RAB5B -0.42 -6.27 -0.33 1.17e-9 Brain structure; CRC cis rs56114371 0.530 rs9357045 chr6:27688927 G/A cg26587870 chr6:27730563 NA -0.45 -6.06 -0.32 3.65e-9 Breast cancer; CRC cis rs10504229 1.000 rs112284078 chr8:58191640 A/G cg02725872 chr8:58115012 NA -0.37 -5.98 -0.31 5.7e-9 Developmental language disorder (linguistic errors); CRC cis rs62244186 0.520 rs9311361 chr3:44796132 T/G cg15687855 chr3:44754131 ZNF502 -0.33 -5.61 -0.3 4.39e-8 Depressive symptoms; CRC trans rs1459104 0.778 rs11827099 chr11:55794945 C/T cg03313212 chr12:104850718 CHST11 -0.5 -5.99 -0.31 5.37e-9 Body mass index; CRC cis rs28386778 0.966 rs2854206 chr17:61947203 G/A cg23090583 chr17:61904693 PSMC5;FTSJ3 1.02 19.47 0.73 1.03e-56 Prudent dietary pattern; CRC cis rs853679 0.517 rs36078605 chr6:28078032 A/C cg15786705 chr6:28176104 NA 0.76 9.34 0.46 1.53e-18 Depression; CRC cis rs12477438 0.765 rs6750876 chr2:99679673 C/T cg26064155 chr2:99771622 LIPT1;TSGA10 -0.63 -8.55 -0.43 4.61e-16 Chronic sinus infection; CRC cis rs8077889 0.917 rs4793037 chr17:41914826 C/T cg25876840 chr17:41920477 NA 0.58 8.23 0.41 4.34e-15 Triglycerides; CRC cis rs2396545 0.591 rs12802200 chr11:566936 C/A cg11503833 chr11:492997 NA 0.47 5.63 0.3 3.85e-8 Systemic lupus erythematosus and Systemic sclerosis; CRC cis rs2841277 0.708 rs9671643 chr14:105408030 A/G cg14403583 chr14:105418241 AHNAK2 -0.33 -6.04 -0.32 4.21e-9 Rheumatoid arthritis; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg05639258 chr11:64879330 TM7SF2 0.48 6.29 0.33 1.03e-9 Anxiety disorder; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg05519310 chr11:66627619 PC;LRFN4 -0.38 -6.84 -0.35 3.84e-11 Liver disease severity in Alagille syndrome; CRC cis rs9399135 0.967 rs9389256 chr6:135331254 A/C cg22676075 chr6:135203613 NA 0.41 6.32 0.33 8.47e-10 Red blood cell count; CRC cis rs7208859 0.623 rs73269988 chr17:29118145 G/A cg13385521 chr17:29058706 SUZ12P 0.74 8.44 0.42 9.97e-16 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs9837602 1.000 rs34626154 chr3:99756312 G/A cg07805332 chr3:99536008 MIR548G;C3orf26 -0.48 -6.16 -0.32 2.16e-9 Breast cancer; CRC cis rs1862618 0.671 rs2591965 chr5:56236176 T/C cg03609598 chr5:56110824 MAP3K1 0.59 7.94 0.4 3.29e-14 Initial pursuit acceleration; CRC cis rs12541335 0.639 rs7003478 chr8:22201123 A/G cg02788857 chr8:22132959 PIWIL2 0.5 8.55 0.43 4.56e-16 Hypertriglyceridemia; CRC cis rs10504073 0.647 rs12156111 chr8:50017328 G/C cg00325661 chr8:49890786 NA 0.46 8.35 0.42 1.92e-15 Blood metabolite ratios; CRC cis rs172166 0.694 rs203893 chr6:28062066 C/A cg10876282 chr6:28092338 ZSCAN16 0.5 6.75 0.35 6.5500000000000006e-11 Cardiac Troponin-T levels; CRC cis rs7208859 0.673 rs61223749 chr17:29163747 G/A cg01831904 chr17:28903510 LRRC37B2 -0.55 -5.75 -0.3 2.01e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC trans rs4650994 0.525 rs10913574 chr1:178536482 G/C cg05059571 chr16:84539110 KIAA1609 -0.53 -7.31 -0.37 2.04e-12 HDL cholesterol levels;HDL cholesterol; CRC cis rs7781266 0.790 rs4728284 chr7:133102295 A/T cg03336402 chr7:133662267 EXOC4 0.5 5.94 0.31 7.19e-9 Educational attainment (college completion); CRC cis rs2404602 0.692 rs58361452 chr15:76973372 T/C cg23625390 chr15:77176239 SCAPER 0.49 7.19 0.37 4.36e-12 Blood metabolite levels; CRC cis rs7044106 0.791 rs7036766 chr9:123479621 G/A cg09586646 chr9:123605570 PSMD5;LOC253039 0.65 9.52 0.46 3.88e-19 Hip circumference adjusted for BMI; CRC cis rs2932538 0.883 rs6537740 chr1:113080084 T/G cg22162597 chr1:113214053 CAPZA1 0.69 9.54 0.47 3.3e-19 Systolic blood pressure;Diastolic blood pressure;Hypertension;Blood pressure; CRC trans rs3780486 0.957 rs10971434 chr9:33168891 C/A cg20290983 chr6:43655470 MRPS18A 1.02 15.64 0.65 1.26e-41 IgG glycosylation; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg22855052 chr12:6982535 SPSB2 0.37 6.64 0.34 1.28e-10 Liver disease severity in Alagille syndrome; CRC cis rs7914558 1.000 rs8139 chr10:104848123 G/A cg15744005 chr10:104629667 AS3MT -0.34 -7.28 -0.37 2.54e-12 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC trans rs7618501 1.000 rs11709680 chr3:49745188 C/T cg21665057 chr3:196295764 WDR53;FBXO45 -0.85 -15.8 -0.66 3.09e-42 Intelligence (multi-trait analysis); CRC cis rs4713118 0.586 rs6905522 chr6:28086479 A/C cg02631126 chr6:28058918 ZSCAN12L1 0.29 5.87 0.31 1.05e-8 Parkinson's disease; CRC cis rs782590 0.559 rs12617719 chr2:55915826 G/C cg18811423 chr2:55921094 PNPT1 -0.81 -14.27 -0.62 2.58e-36 Metabolic syndrome; CRC cis rs282587 0.569 rs399569 chr13:113398464 A/T cg04656015 chr13:113407548 ATP11A 0.64 7.85 0.4 6.08e-14 Glycated hemoglobin levels; CRC cis rs9420 0.961 rs11570190 chr11:57560452 A/C cg23127183 chr11:57508653 C11orf31 -0.53 -7.17 -0.37 4.83e-12 Schizophrenia; CRC trans rs10506458 1.000 rs11174759 chr12:63444363 A/T cg03429785 chr15:59498649 MYO1E;LDHAL6B -1.33 -19.18 -0.73 1.47e-55 Hemostatic factors and hematological phenotypes; CRC cis rs6088580 0.634 rs1205336 chr20:32926336 G/A cg24642439 chr20:33292090 TP53INP2 -0.42 -6.93 -0.36 2.2e-11 Glomerular filtration rate (creatinine); CRC cis rs17270561 0.636 rs4145218 chr6:25746083 G/A cg16482183 chr6:26056742 HIST1H1C 0.81 10.22 0.49 1.73e-21 Iron status biomarkers; CRC cis rs7605827 0.930 rs7578126 chr2:15522772 C/T cg19274914 chr2:15703543 NA 0.37 5.67 0.3 3.08e-8 Educational attainment (years of education); CRC cis rs12928939 0.859 rs11670 chr16:71679027 G/T cg08717414 chr16:71523259 ZNF19 -0.47 -5.83 -0.31 1.35e-8 Post bronchodilator FEV1; CRC cis rs172166 0.637 rs1233691 chr6:28153897 T/G cg03623178 chr6:28175578 NA 0.86 13.55 0.6 1.59e-33 Cardiac Troponin-T levels; CRC trans rs10842750 1.000 rs10842750 chr12:26690565 G/T cg23459997 chr3:9932426 JAGN1 0.54 6.46 0.34 3.76e-10 Kashin-Beck disease; CRC cis rs10924970 0.967 rs4659784 chr1:235482463 C/T cg26050004 chr1:235667680 B3GALNT2 0.41 6.13 0.32 2.51e-9 Asthma; CRC cis rs780096 0.506 rs780100 chr2:27652153 G/T cg24768116 chr2:27665128 KRTCAP3 -0.35 -8.05 -0.41 1.51e-14 Total body bone mineral density; CRC cis rs933688 1.000 rs6869717 chr5:90694797 G/A cg02339078 chr5:90679543 LOC100129716;ARRDC3 0.92 13.87 0.61 9.28e-35 Smoking behavior; CRC cis rs4665809 1.000 rs4665299 chr2:26256840 A/C cg25036284 chr2:26402008 FAM59B -0.47 -5.84 -0.31 1.22e-8 Gut microbiome composition (summer); CRC cis rs7618915 0.547 rs11130323 chr3:52770277 T/C cg18099408 chr3:52552593 STAB1 -0.44 -7.26 -0.37 2.74e-12 Bipolar disorder; CRC cis rs4076764 0.522 rs4265409 chr1:163414559 C/T cg06092702 chr1:163392909 NA -0.5 -7.92 -0.4 3.78e-14 Motion sickness; CRC cis rs9457247 0.902 rs34560498 chr6:167395862 A/G cg23791538 chr6:167370224 RNASET2 -0.37 -5.76 -0.3 1.92e-8 Crohn's disease; CRC cis rs6582630 0.519 rs4405392 chr12:38293661 A/C cg26384229 chr12:38710491 ALG10B 0.69 9.79 0.47 5.01e-20 Drug-induced liver injury (flucloxacillin); CRC cis rs1712517 0.525 rs11191667 chr10:105128898 G/A cg04362960 chr10:104952993 NT5C2 -0.44 -5.71 -0.3 2.51e-8 Migraine; CRC cis rs3749237 0.595 rs11130196 chr3:49490149 A/C cg02487422 chr3:49467188 NICN1 0.41 6.71 0.35 8.45e-11 Resting heart rate; CRC cis rs10504229 0.953 rs72650891 chr8:58179697 T/G cg24829409 chr8:58192753 C8orf71 -0.68 -11.34 -0.53 2.27e-25 Developmental language disorder (linguistic errors); CRC cis rs4073416 0.568 rs7158153 chr14:66034586 C/A cg03016385 chr14:66212404 NA -0.45 -6.27 -0.33 1.14e-9 N-glycan levels; CRC cis rs9902453 0.967 rs8067576 chr17:28444254 T/A cg26525008 chr17:28256777 EFCAB5;SSH2 0.56 8.5 0.42 6.81e-16 Coffee consumption (cups per day); CRC cis rs6496667 0.955 rs8039263 chr15:90900597 G/A cg04176472 chr15:90893244 GABARAPL3 0.49 7.42 0.38 1e-12 Rheumatoid arthritis; CRC cis rs11676348 0.901 rs7562334 chr2:219003360 G/A cg04731861 chr2:219085781 ARPC2 0.27 5.69 0.3 2.83e-8 Ulcerative colitis; CRC cis rs8180040 0.966 rs13079098 chr3:47442863 A/G cg02527881 chr3:46936655 PTH1R -0.37 -7.02 -0.36 1.3e-11 Colorectal cancer; CRC cis rs3733585 0.726 rs4306953 chr4:9955776 G/A cg11266682 chr4:10021025 SLC2A9 -0.47 -9.59 -0.47 2.27e-19 Cleft plate (environmental tobacco smoke interaction); CRC cis rs77861329 1.000 rs9843299 chr3:52137469 G/T cg08692210 chr3:52188851 WDR51A 0.82 6.95 0.36 1.98e-11 Macrophage inflammatory protein 1b levels; CRC cis rs7215564 0.818 rs35059200 chr17:78661619 T/C cg09596252 chr17:78655493 RPTOR 0.56 6.16 0.32 2.11e-9 Myopia (pathological); CRC trans rs1814175 0.817 rs7109440 chr11:49966296 C/T cg03929089 chr4:120376271 NA -0.93 -17.47 -0.69 8.08e-49 Height; CRC cis rs10504229 0.861 rs57942497 chr8:58171239 G/T cg02725872 chr8:58115012 NA -0.38 -6.43 -0.33 4.44e-10 Developmental language disorder (linguistic errors); CRC cis rs13315871 1.000 rs13315871 chr3:58381287 G/A cg20936604 chr3:58311152 NA -0.71 -6.5 -0.34 2.93e-10 Cholesterol, total; CRC cis rs644799 1.000 rs525404 chr11:95566520 A/G cg25478527 chr11:95522999 CEP57;FAM76B 0.52 7.77 0.39 9.84e-14 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC trans rs2303319 0.504 rs12467625 chr2:162603387 C/A cg23247704 chr1:116518985 SLC22A15 -0.72 -6.14 -0.32 2.42e-9 Cognitive function; CRC cis rs10782582 0.593 rs11163967 chr1:76154185 T/C cg10523679 chr1:76189770 ACADM -0.41 -5.78 -0.3 1.72e-8 Daytime sleep phenotypes; CRC cis rs9296092 0.538 rs62405942 chr6:33517346 G/A cg13560919 chr6:33536144 NA -0.43 -5.98 -0.31 5.72e-9 Age at smoking initiation in chronic obstructive pulmonary disease; CRC cis rs7772486 0.597 rs1970306 chr6:146154543 A/G cg13319975 chr6:146136371 FBXO30 -0.62 -8.99 -0.44 2.04e-17 Lobe attachment (rater-scored or self-reported); CRC cis rs2032447 0.869 rs2230655 chr6:26033506 A/G cg03517284 chr6:25882590 NA 0.51 6.95 0.36 1.95e-11 Intelligence (multi-trait analysis); CRC cis rs4974559 0.585 rs1680025 chr4:1265477 T/C cg02980000 chr4:1222292 CTBP1 -0.43 -5.62 -0.3 4.02e-8 Systolic blood pressure; CRC cis rs992157 0.835 rs2292551 chr2:219143229 G/A cg04880052 chr2:219191631 PNKD -0.44 -6.98 -0.36 1.66e-11 Colorectal cancer; CRC cis rs2180341 1.000 rs13218061 chr6:127653758 G/A cg24812749 chr6:127587940 RNF146 0.95 13.72 0.6 3.35e-34 Breast cancer; CRC cis rs17095355 1.000 rs12267714 chr10:111722052 C/T cg00817464 chr10:111662876 XPNPEP1 -0.63 -8.52 -0.43 5.89e-16 Biliary atresia; CRC cis rs13118159 0.573 rs4974618 chr4:1373663 C/T cg20887711 chr4:1340912 KIAA1530 0.68 9.69 0.47 1.03e-19 Longevity; CRC cis rs1552244 1.000 rs6791810 chr3:10124444 A/G cg18598329 chr3:10140678 FANCD2;C3orf24 0.92 13.04 0.58 1.32e-31 Alzheimer's disease; CRC cis rs875971 0.830 rs778715 chr7:65849209 C/T cg12463550 chr7:65579703 CRCP 0.5 6.98 0.36 1.65e-11 Aortic root size; CRC cis rs780096 0.526 rs7602534 chr2:27592423 C/T cg21248554 chr2:27665150 KRTCAP3 -0.3 -6.84 -0.35 3.78e-11 Total body bone mineral density; CRC cis rs57590327 0.555 rs13062054 chr3:81833906 A/G cg07356753 chr3:81810745 GBE1 -0.65 -8.89 -0.44 4.25e-17 Extraversion; CRC cis rs7666738 0.830 rs34070283 chr4:98893027 A/T cg17366294 chr4:99064904 C4orf37 0.42 6.91 0.36 2.5e-11 Colonoscopy-negative controls vs population controls; CRC cis rs7959452 0.535 rs11615712 chr12:69619736 A/T cg14784868 chr12:69753453 YEATS4 -0.73 -11.77 -0.54 6.36e-27 Blood protein levels; CRC cis rs11724804 0.532 rs62297079 chr4:879977 G/A cg20814179 chr4:940893 TMEM175 0.61 10.47 0.5 2.56e-22 Primary biliary cholangitis;Limited cutaneous systemic scleroderma; CRC cis rs1003719 0.788 rs2835578 chr21:38457671 T/C cg10648535 chr21:38446584 PIGP;TTC3 0.51 7.21 0.37 3.79e-12 Eye color traits; CRC cis rs9467711 0.606 rs9358939 chr6:26416787 C/G cg14345882 chr6:26364793 BTN3A2 0.7 5.75 0.3 2.03e-8 Autism spectrum disorder or schizophrenia; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg09085639 chr17:79670810 MRPL12 0.44 6.52 0.34 2.69e-10 Intelligence (multi-trait analysis); CRC cis rs10788264 0.544 rs9630110 chr10:124017308 C/T cg05683857 chr10:124030795 BTBD16 -0.32 -5.74 -0.3 2.19e-8 Total body bone mineral density; CRC cis rs6741819 0.911 rs2292931 chr2:7137488 A/G cg27144453 chr2:7172511 RNF144A -0.41 -5.99 -0.31 5.49e-9 Response to antipsychotic treatment; CRC cis rs17162190 0.698 rs4659375 chr1:26804090 G/A cg17456097 chr1:26900765 RPS6KA1 0.44 6.37 0.33 6.31e-10 Mean corpuscular volume; CRC cis rs864537 0.618 rs1214595 chr1:167427557 G/A cg09179987 chr1:167433047 CD247 0.5 7.38 0.38 1.32e-12 Celiac disease or Rheumatoid arthritis;Celiac disease; CRC cis rs9549328 0.565 rs35988856 chr13:113617427 T/C cg24588162 chr13:113633484 MCF2L 0.36 6.52 0.34 2.68e-10 Systolic blood pressure; CRC cis rs7666738 0.830 rs28594127 chr4:99001121 T/G cg17366294 chr4:99064904 C4orf37 0.44 7.39 0.38 1.19e-12 Colonoscopy-negative controls vs population controls; CRC cis rs67478160 0.595 rs12879501 chr14:104272634 G/T cg08213375 chr14:104286397 PPP1R13B 0.62 12.96 0.58 2.67e-31 Schizophrenia; CRC cis rs10450586 0.932 rs899302 chr11:27309577 T/C cg10370305 chr11:27303972 NA 0.35 5.7 0.3 2.68e-8 Total body bone mineral density; CRC cis rs4722166 0.598 rs4722171 chr7:22785717 A/G cg26061582 chr7:22766209 IL6 0.55 8.34 0.42 2.03e-15 Lung cancer; CRC cis rs13108904 0.875 rs1732099 chr4:1282696 T/C cg21620606 chr4:1342894 KIAA1530 -0.42 -7.68 -0.39 1.8e-13 Obesity-related traits; CRC cis rs7523050 0.730 rs12726126 chr1:109436128 A/G cg08274380 chr1:109419600 GPSM2 0.89 7.75 0.39 1.18e-13 Fat distribution (HIV); CRC cis rs155076 0.666 rs9509640 chr13:21872880 T/C cg21970626 chr13:21893289 NA -0.43 -6.21 -0.32 1.64e-9 White matter hyperintensity burden; CRC trans rs117598310 0.915 rs41318744 chr8:75922760 A/C cg22249754 chr7:5353456 TNRC18 -0.45 -6.03 -0.32 4.47e-9 Optic cup area; CRC cis rs7927771 0.965 rs4752845 chr11:47539697 T/C cg20307385 chr11:47447363 PSMC3 -0.56 -7.81 -0.4 7.68e-14 Subjective well-being; CRC cis rs2742417 0.603 rs2742371 chr3:45782763 G/A cg04837898 chr3:45731254 SACM1L -0.48 -7.72 -0.39 1.45e-13 Response to anti-depressant treatment in major depressive disorder; CRC cis rs17376456 0.825 rs13361613 chr5:93272176 C/T cg21475434 chr5:93447410 FAM172A 0.83 8.23 0.41 4.37e-15 Diabetic retinopathy; CRC cis rs2839186 0.771 rs2280959 chr21:47641996 C/G cg11766577 chr21:47581405 C21orf56 -0.51 -8.33 -0.42 2.24e-15 Testicular germ cell tumor; CRC cis rs4481887 0.741 rs11488133 chr1:248548380 T/C cg26353448 chr1:248524236 OR2T4 -0.32 -6.17 -0.32 1.97e-9 Common traits (Other); CRC cis rs9322193 0.923 rs7769101 chr6:150169904 C/A cg05861140 chr6:150128134 PCMT1 -0.42 -6.99 -0.36 1.53e-11 Lung cancer; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg11450715 chr2:171627404 NA 0.37 6.34 0.33 7.53e-10 Liver disease severity in Alagille syndrome; CRC cis rs7927592 0.956 rs11228256 chr11:68251460 G/A cg01657329 chr11:68192670 LRP5 -0.46 -6.67 -0.35 1.09e-10 Total body bone mineral density; CRC cis rs11098499 0.954 rs10005644 chr4:120298477 T/C cg09307838 chr4:120376055 NA 0.71 10.93 0.52 6.41e-24 Corneal astigmatism; CRC cis rs9549367 0.713 rs4907593 chr13:113830459 C/T cg18105134 chr13:113819100 PROZ 0.83 13.18 0.59 3.79e-32 Platelet distribution width; CRC cis rs9323205 0.906 rs11629336 chr14:51686620 A/C cg23942311 chr14:51606299 NA 0.46 5.86 0.31 1.12e-8 Cancer; CRC cis rs4731207 0.596 rs11980178 chr7:124604660 A/G cg23710748 chr7:124431027 NA -0.38 -6.08 -0.32 3.35e-9 Cutaneous malignant melanoma; CRC cis rs637571 0.522 rs503524 chr11:65751764 C/T cg17985854 chr11:65770987 BANF1;EIF1AD 0.52 8.78 0.44 9.24e-17 Eosinophil percentage of white cells; CRC cis rs7216064 0.651 rs12947658 chr17:65903006 A/G cg12091567 chr17:66097778 LOC651250 0.54 7.3 0.37 2.16e-12 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CRC cis rs5758659 0.652 rs133349 chr22:42428727 A/T cg15557168 chr22:42548783 NA -0.34 -5.62 -0.3 4.08e-8 Cognitive function; CRC cis rs875971 0.520 rs2420597 chr7:65915986 A/G cg00343986 chr7:65444356 GUSB 0.42 5.85 0.31 1.22e-8 Aortic root size; CRC cis rs11148252 0.740 rs9596643 chr13:52912380 G/A cg00495681 chr13:53174319 NA -0.56 -8.17 -0.41 6.7e-15 Lewy body disease; CRC cis rs4665809 0.590 rs4665318 chr2:26424517 C/T cg08067268 chr2:26466485 HADHB;HADHA 0.66 8.28 0.42 3.08e-15 Gut microbiome composition (summer); CRC cis rs4290604 0.748 rs78545853 chr2:238005148 C/T cg23555395 chr2:238036564 NA 0.6 6.14 0.32 2.41e-9 Asthma; CRC trans rs853679 0.546 rs200989 chr6:27816442 A/G cg06606381 chr12:133084897 FBRSL1 -0.77 -6.62 -0.34 1.46e-10 Depression; CRC cis rs9549260 0.755 rs2297627 chr13:41233931 A/G cg21288729 chr13:41239152 FOXO1 0.48 7.48 0.38 6.7e-13 Red blood cell count; CRC cis rs6952808 0.624 rs60137119 chr7:2083664 A/G cg02951883 chr7:2050386 MAD1L1 -0.75 -11.58 -0.54 3.11e-26 Bipolar disorder and schizophrenia; CRC cis rs7927592 0.513 rs7950129 chr11:68202903 A/G cg01657329 chr11:68192670 LRP5 -0.58 -9.3 -0.46 2.03e-18 Total body bone mineral density; CRC cis rs7223966 1.000 rs7223412 chr17:61808172 T/C cg05941027 chr17:61774174 LIMD2 0.36 6.4 0.33 5.23e-10 Hip circumference adjusted for BMI;Body mass index; CRC trans rs2303319 0.504 rs62189055 chr2:162625749 C/A cg20397358 chr22:38597902 MAFF -0.71 -6.17 -0.32 2.03e-9 Cognitive function; CRC cis rs9399135 0.684 rs1135205 chr6:135281795 C/T cg22676075 chr6:135203613 NA 0.46 6.95 0.36 1.97e-11 Red blood cell count; CRC cis rs2011503 1.000 rs1560687 chr19:19562902 G/A cg11584989 chr19:19387371 SF4 0.52 5.88 0.31 9.9e-9 Bipolar disorder; CRC cis rs2303745 0.589 rs1965717 chr19:17398559 C/T cg04248312 chr19:17393744 ANKLE1 -0.94 -13.97 -0.61 3.66e-35 Systemic lupus erythematosus; CRC trans rs7937682 0.883 rs549143 chr11:111463779 C/T cg18187862 chr3:45730750 SACM1L 0.43 6.14 0.32 2.38e-9 Primary sclerosing cholangitis; CRC cis rs10782582 0.609 rs10873797 chr1:76377191 G/T cg03433033 chr1:76189801 ACADM -0.42 -6.1 -0.32 2.94e-9 Daytime sleep phenotypes; CRC cis rs950169 0.580 rs11636189 chr15:85193554 G/A cg17507749 chr15:85114479 UBE2QP1 0.63 9.01 0.44 1.71e-17 Schizophrenia; CRC cis rs10927875 1.000 rs3979179 chr1:16306846 A/G cg21385522 chr1:16154831 NA 0.7 9.14 0.45 6.76e-18 Dilated cardiomyopathy; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg05658717 chr12:118407033 KSR2 -0.4 -6.04 -0.32 4.16e-9 Myopia (pathological); CRC trans rs9329221 1.000 rs9329221 chr8:10240202 G/T cg06636001 chr8:8085503 FLJ10661 0.51 8.01 0.4 1.99e-14 Neuroticism; CRC cis rs6951245 1.000 rs11763020 chr7:1060288 C/T cg21664854 chr7:1097933 C7orf50;GPR146 0.75 8.45 0.42 9.74e-16 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs524023 1.000 rs10792441 chr11:64360629 C/T cg06522879 chr11:64358276 SLC22A12 -0.59 -9.31 -0.46 1.86e-18 Urate levels in obese individuals; CRC cis rs67311347 1.000 rs7642906 chr3:40492633 G/A cg09455208 chr3:40491958 NA -0.42 -8.52 -0.43 5.87e-16 Renal cell carcinoma; CRC trans rs75804782 0.557 rs3769118 chr2:239342542 C/G cg01134436 chr17:81009848 B3GNTL1 0.58 6.49 0.34 3.15e-10 Morning vs. evening chronotype;Chronotype; CRC cis rs6479527 0.904 rs10122334 chr9:96864227 A/G cg13460858 chr9:96720652 NA 0.31 5.6 0.3 4.49e-8 Esophageal adenocarcinoma; CRC cis rs1448094 0.556 rs17279916 chr12:86170647 G/A cg19622623 chr12:86230825 RASSF9 -0.37 -5.6 -0.3 4.45e-8 Major depressive disorder; CRC cis rs9341808 0.644 rs62408577 chr6:80942024 T/A cg08355045 chr6:80787529 NA -0.36 -6.05 -0.32 4.01e-9 Sitting height ratio; CRC cis rs7827545 1.000 rs7823948 chr8:135566580 G/A cg07299736 chr8:135490787 ZFAT -0.39 -6.48 -0.34 3.27e-10 Hypertension (SNP x SNP interaction); CRC trans rs13046373 0.905 rs4816372 chr21:32077414 A/T cg20899266 chr3:9471176 SETD5 -0.41 -6.4 -0.33 5.49e-10 HDL cholesterol; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg03487115 chr7:91569843 AKAP9 0.41 6.09 0.32 3.08e-9 Intelligence (multi-trait analysis); CRC cis rs66573146 1.000 rs55688389 chr4:7030689 C/G cg00086871 chr4:6988644 TBC1D14 0.88 6.48 0.34 3.32e-10 Granulocyte percentage of myeloid white cells; CRC cis rs4731207 0.698 rs11975788 chr7:124497811 T/A cg23710748 chr7:124431027 NA -0.38 -6.08 -0.32 3.42e-9 Cutaneous malignant melanoma; CRC cis rs832540 0.898 rs331498 chr5:56249842 C/G cg24531977 chr5:56204891 C5orf35 0.48 7.38 0.38 1.27e-12 Coronary artery disease; CRC cis rs9409565 0.826 rs9409556 chr9:97239268 T/C cg04523069 chr9:97136363 HIATL1 0.37 5.62 0.3 4.05e-8 Colorectal cancer (alcohol consumption interaction); CRC cis rs58688157 0.705 rs7112149 chr11:595890 G/A cg07212818 chr11:638076 DRD4 -0.45 -5.81 -0.31 1.48e-8 Systemic lupus erythematosus; CRC cis rs7412746 0.611 rs16827671 chr1:150738759 T/C cg18016565 chr1:150552671 MCL1 0.42 5.8 0.3 1.57e-8 Melanoma; CRC cis rs10504229 0.683 rs2291765 chr8:58142874 C/T cg21724239 chr8:58056113 NA 0.41 5.86 0.31 1.12e-8 Developmental language disorder (linguistic errors); CRC cis rs1552244 1.000 rs7610821 chr3:10136150 C/T cg08888203 chr3:10149979 C3orf24 0.67 9.59 0.47 2.36e-19 Alzheimer's disease; CRC cis rs904251 0.861 rs2776875 chr6:37486796 G/C cg25019722 chr6:37503610 NA -0.51 -9.49 -0.46 4.84e-19 Cognitive performance; CRC cis rs11155671 0.530 rs9969044 chr6:150209204 A/G cg07701084 chr6:150067640 NUP43 0.52 7.03 0.36 1.2e-11 Testicular germ cell tumor; CRC cis rs2576037 0.526 rs4890703 chr18:44522037 A/G cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.71 -11.16 -0.52 9.91e-25 Personality dimensions; CRC trans rs17234274 0.500 rs1384489 chr11:23225422 C/G cg00531246 chr13:114174973 TMCO3 -0.35 -6.03 -0.32 4.31e-9 Cancer; CRC cis rs2839186 0.560 rs9975345 chr21:47843004 T/C cg13126279 chr21:47581558 C21orf56 0.35 5.6 0.3 4.49e-8 Testicular germ cell tumor; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg25412384 chr14:23341283 LRP10 0.47 6.23 0.32 1.43e-9 Thyroid stimulating hormone; CRC cis rs311392 0.902 rs423150 chr8:55092804 C/T cg20636351 chr8:55087400 NA -0.33 -5.96 -0.31 6.62e-9 Pelvic organ prolapse (moderate/severe); CRC cis rs9291683 0.610 rs993172 chr4:10324361 G/T cg00071950 chr4:10020882 SLC2A9 0.49 8.01 0.4 1.97e-14 Bone mineral density; CRC cis rs9896933 0.732 rs590886 chr17:80767350 A/G cg15369054 chr17:80825471 TBCD -0.48 -5.86 -0.31 1.15e-8 Bone mineral accretion in asthma (oral corticosteroid dose interaction); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg13679077 chr7:22862647 TOMM7 0.41 6.36 0.33 6.57e-10 Liver disease severity in Alagille syndrome; CRC cis rs362272 0.524 rs7435601 chr4:3369645 A/G cg02993699 chr4:3415135 RGS12 -0.38 -6.26 -0.33 1.18e-9 Serum sulfate level; CRC cis rs798554 0.796 rs2533884 chr7:2836848 T/G cg13628971 chr7:2884303 GNA12 0.54 7.18 0.37 4.54e-12 Height; CRC cis rs873946 0.504 rs12254034 chr10:134571007 T/C cg06453172 chr10:134556979 INPP5A -0.62 -8.18 -0.41 6.12e-15 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CRC cis rs12760731 0.843 rs12033565 chr1:178491966 A/G cg00404053 chr1:178313656 RASAL2 -0.63 -6.79 -0.35 5.37e-11 Obesity-related traits; CRC cis rs929354 0.772 rs1182360 chr7:157020550 C/G cg17757837 chr7:157058334 UBE3C 0.76 12.9 0.58 4.36e-31 Body mass index; CRC cis rs7726839 0.540 rs11739847 chr5:609661 G/A cg09021430 chr5:549028 NA -0.73 -8.35 -0.42 1.94e-15 Obesity-related traits; CRC cis rs2836974 0.644 rs7281853 chr21:40693490 A/G cg11890956 chr21:40555474 PSMG1 -0.81 -12.49 -0.57 1.48e-29 Cognitive function; CRC cis rs9296092 0.538 rs9469491 chr6:33521545 A/G cg13560919 chr6:33536144 NA 0.42 5.93 0.31 7.69e-9 Age at smoking initiation in chronic obstructive pulmonary disease; CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg15094104 chr5:133406808 NA -0.5 -6.32 -0.33 8.39e-10 Diisocyanate-induced asthma; CRC cis rs9443645 0.901 rs2174739 chr6:79659170 C/T cg11833968 chr6:79620685 NA 0.37 6.28 0.33 1.07e-9 Intelligence (multi-trait analysis); CRC cis rs10982256 0.774 rs10817626 chr9:117254541 G/A cg13636371 chr9:117264095 DFNB31 0.37 7.01 0.36 1.33e-11 Bipolar disorder; CRC cis rs6582630 0.555 rs34884627 chr12:38443831 C/T cg26384229 chr12:38710491 ALG10B -0.51 -7.34 -0.37 1.73e-12 Drug-induced liver injury (flucloxacillin); CRC cis rs561341 1.000 rs72825712 chr17:30316119 A/T cg00745463 chr17:30367425 LRRC37B -0.89 -9.77 -0.47 6.01e-20 Hip circumference adjusted for BMI; CRC cis rs883565 0.543 rs35628459 chr3:39174437 T/A cg01426195 chr3:39028469 NA 0.4 6.5 0.34 2.92e-10 Handedness; CRC cis rs6835098 0.520 rs2127896 chr4:174211285 G/A cg08422745 chr4:174089978 GALNT7 -0.64 -9.0 -0.44 1.91e-17 Dementia and core Alzheimer's disease neuropathologic changes; CRC cis rs769267 0.929 rs34538000 chr19:19481379 G/T cg03709012 chr19:19516395 GATAD2A -0.73 -11.35 -0.53 1.97e-25 Tonsillectomy; CRC cis rs2243480 1.000 rs73142122 chr7:65311298 C/A cg18252515 chr7:66147081 NA -1.17 -13.25 -0.59 2.03e-32 Diabetic kidney disease; CRC cis rs9549367 0.713 rs3024761 chr13:113824090 C/G cg00898013 chr13:113819073 PROZ 0.56 8.06 0.41 1.4e-14 Platelet distribution width; CRC cis rs11958404 0.860 rs72818117 chr5:157441130 G/A cg05962755 chr5:157440814 NA 1.02 12.7 0.57 2.45e-30 IgG glycosylation; CRC cis rs3785574 0.962 rs2727324 chr17:61922102 G/C cg11494091 chr17:61959527 GH2 0.37 5.8 0.3 1.6e-8 Height; CRC cis rs826838 1.000 rs12366971 chr12:38737687 T/G cg26384229 chr12:38710491 ALG10B 0.76 10.92 0.52 6.69e-24 Heart rate; CRC cis rs754466 0.580 rs2579178 chr10:79529215 A/G cg26805224 chr10:79626177 DLG5 0.48 7.02 0.36 1.31e-11 Liver enzyme levels (gamma-glutamyl transferase); CRC trans rs2303319 0.504 rs62189052 chr2:162623869 C/G cg23247704 chr1:116518985 SLC22A15 -0.72 -6.12 -0.32 2.7e-9 Cognitive function; CRC cis rs13394619 0.936 rs9789414 chr2:11724684 A/G cg07314298 chr2:11723111 GREB1 -0.49 -8.2 -0.41 5.52e-15 Endometriosis; CRC cis rs5769765 0.818 rs138850 chr22:50193337 C/T cg04121214 chr22:50244548 NA -0.4 -6.31 -0.33 8.91e-10 Schizophrenia; CRC cis rs597539 0.652 rs636049 chr11:68667198 A/C cg21963583 chr11:68658836 MRPL21 0.63 11.67 0.54 1.42e-26 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs2289681 0.583 rs2289674 chr17:42953409 A/G cg15193461 chr17:42977049 CCDC103;EFTUD2 -0.53 -6.22 -0.32 1.53e-9 Cognitive function; CRC cis rs4731207 0.596 rs6964090 chr7:124667116 G/A cg23710748 chr7:124431027 NA -0.38 -6.03 -0.32 4.36e-9 Cutaneous malignant melanoma; CRC trans rs7395662 0.591 rs4882233 chr11:48739653 A/G cg03929089 chr4:120376271 NA -0.49 -7.18 -0.37 4.75e-12 HDL cholesterol; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg13928520 chr1:146522365 NA -0.37 -5.97 -0.31 6.01e-9 Liver disease severity in Alagille syndrome; CRC cis rs7538876 0.935 rs2526827 chr1:17730825 G/A cg07965774 chr1:17746286 RCC2 0.3 5.73 0.3 2.29e-8 Basal cell carcinoma; CRC cis rs11608355 1.000 rs10774690 chr12:109859682 G/A cg19025524 chr12:109796872 NA -0.47 -6.72 -0.35 8.22e-11 Neuroticism; CRC cis rs3785574 0.962 rs2247435 chr17:61892862 G/A cg23090583 chr17:61904693 PSMC5;FTSJ3 0.65 9.26 0.45 2.71e-18 Height; CRC cis rs9322193 0.923 rs9800580 chr6:149953981 C/T cg05861140 chr6:150128134 PCMT1 -0.36 -5.92 -0.31 8.26e-9 Lung cancer; CRC cis rs478304 0.934 rs570954 chr11:65498261 A/G cg08755490 chr11:65554678 OVOL1 0.43 6.39 0.33 5.53e-10 Acne (severe); CRC cis rs6752107 1.000 rs2241878 chr2:234183718 T/C cg07618928 chr2:234183455 ATG16L1;SCARNA5 0.66 11.37 0.53 1.73e-25 Crohn's disease;Inflammatory bowel disease; CRC cis rs295140 0.546 rs295134 chr2:201110223 A/G cg23649088 chr2:200775458 C2orf69 -0.41 -5.97 -0.31 6.19e-9 QT interval; CRC trans rs711355 0.872 rs785423 chr15:30174376 A/G cg19414016 chr13:113697165 MCF2L -0.42 -6.3 -0.33 9.44e-10 Response to antipsychotic treatment; CRC cis rs7927592 0.871 rs871212 chr11:68348695 T/A cg01657329 chr11:68192670 LRP5 -0.49 -7.18 -0.37 4.66e-12 Total body bone mineral density; CRC cis rs2239547 0.603 rs2276825 chr3:52886605 T/C cg18404041 chr3:52824283 ITIH1 -0.39 -7.26 -0.37 2.73e-12 Schizophrenia; CRC cis rs4713118 0.666 rs4140646 chr6:27738801 G/A cg12172441 chr6:28176163 NA 0.6 6.56 0.34 2.1e-10 Parkinson's disease; CRC trans rs11098499 0.698 rs4422403 chr4:120258194 C/T cg25214090 chr10:38739885 LOC399744 0.56 9.11 0.45 7.96e-18 Corneal astigmatism; CRC cis rs7428 0.527 rs1061782 chr2:85546615 A/G cg24342717 chr2:85555507 TGOLN2 0.77 13.21 0.59 3.08e-32 Ear protrusion; CRC cis rs968567 0.817 rs61896141 chr11:61556039 A/C cg25303599 chr11:61595807 FADS2 -0.49 -6.53 -0.34 2.53e-10 Blood metabolite levels;Rheumatoid arthritis;Vitiligo;Glycerophospholipid levels; CRC cis rs3796352 1.000 rs34979715 chr3:53048960 G/A cg06204229 chr3:52865917 ITIH4 0.5 5.76 0.3 1.98e-8 Immune reponse to smallpox (secreted IL-2); CRC cis rs4478858 0.735 rs10914360 chr1:31817476 G/A cg00250761 chr1:31883323 NA -0.4 -7.53 -0.38 4.98e-13 Alcohol dependence; CRC cis rs1218582 0.772 rs4845693 chr1:154911257 A/G cg24250549 chr1:154909240 PMVK -0.58 -9.43 -0.46 7.56e-19 Prostate cancer; CRC cis rs13217239 0.585 rs114919438 chr6:26963792 T/C cg12292205 chr6:26970375 C6orf41 -0.59 -9.84 -0.48 3.37e-20 Schizophrenia; CRC cis rs9341808 0.600 rs590641 chr6:80966483 A/G cg08355045 chr6:80787529 NA 0.35 5.83 0.31 1.32e-8 Sitting height ratio; CRC cis rs9560113 1.000 rs60374273 chr13:112179206 A/T cg10483660 chr13:112241077 NA 0.36 5.81 0.3 1.49e-8 Menarche (age at onset); CRC trans rs208520 0.690 rs6932475 chr6:66863155 G/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.05 -14.82 -0.63 2.09e-38 Exhaled nitric oxide output; CRC cis rs514406 0.929 rs485631 chr1:53330245 A/G cg27535305 chr1:53392650 SCP2 -0.39 -7.04 -0.36 1.13e-11 Monocyte count; CRC cis rs11212617 1.000 rs228591 chr11:108097333 A/G cg14761454 chr11:108092087 ATM;NPAT 0.46 6.91 0.36 2.5e-11 Response to metformin in type 2 diabetes (glycemic); CRC cis rs4713118 0.547 rs2116981 chr6:28067951 T/G cg02631126 chr6:28058918 ZSCAN12L1 0.3 6.11 0.32 2.83e-9 Parkinson's disease; CRC cis rs9910055 0.529 rs615070 chr17:42176591 A/G cg09913183 chr17:42254507 C17orf65;ASB16 0.46 6.38 0.33 5.86e-10 Total body bone mineral density; CRC cis rs28386778 0.765 rs2070680 chr17:61986988 A/G cg23090583 chr17:61904693 PSMC5;FTSJ3 -0.84 -14.59 -0.63 1.56e-37 Prudent dietary pattern; CRC trans rs208520 0.770 rs1342960 chr6:66883514 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.91 -12.38 -0.56 3.59e-29 Exhaled nitric oxide output; CRC cis rs13161895 1.000 rs35592104 chr5:179447661 A/T cg02702477 chr5:179499311 RNF130 0.51 5.87 0.31 1.04e-8 LDL cholesterol; CRC cis rs10788264 0.504 rs4751887 chr10:124029758 G/A cg09507567 chr10:124027408 NA 0.36 7.75 0.39 1.16e-13 Total body bone mineral density; CRC cis rs2651899 0.902 rs1736522 chr1:3080940 C/G cg22674798 chr1:3096360 PRDM16 0.32 6.63 0.34 1.36e-10 Migraine; CRC cis rs6032067 0.929 rs6017504 chr20:43818920 G/A cg10761708 chr20:43804764 PI3 0.5 5.68 0.3 2.93e-8 Blood protein levels; CRC cis rs9462027 0.628 rs9462026 chr6:34797033 C/G cg07306190 chr6:34760872 UHRF1BP1 -0.35 -6.15 -0.32 2.28e-9 Systemic lupus erythematosus; CRC cis rs6076065 0.802 rs2424527 chr20:23357329 A/C cg11657817 chr20:23433608 CST11 0.54 9.06 0.45 1.16e-17 Facial morphology (factor 15, philtrum width); CRC cis rs1046896 0.731 rs9906115 chr17:80791469 G/A cg08200770 chr17:80723486 TBCD -0.51 -7.76 -0.39 1.1e-13 Glycated hemoglobin levels; CRC cis rs1005277 0.579 rs2474580 chr10:38398713 G/A cg17219203 chr10:38645113 HSD17B7P2 -0.41 -5.77 -0.3 1.8e-8 Extrinsic epigenetic age acceleration; CRC cis rs6951245 1.000 rs77305932 chr7:1100861 T/A cg24642844 chr7:1081250 C7orf50 -0.76 -9.16 -0.45 5.78e-18 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs853679 0.517 rs9295761 chr6:28147987 A/G cg15786705 chr6:28176104 NA 0.8 9.96 0.48 1.31e-20 Depression; CRC cis rs2032447 0.798 rs807212 chr6:26065621 A/G cg12588279 chr6:26043732 HIST1H2BB 0.47 6.75 0.35 6.74e-11 Intelligence (multi-trait analysis); CRC cis rs6840360 0.571 rs4696101 chr4:152528513 A/G cg09659197 chr4:152720779 NA 0.32 5.75 0.3 1.99e-8 Intelligence (multi-trait analysis); CRC cis rs597539 0.652 rs654071 chr11:68653432 A/C cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.9 15.68 0.65 8.67e-42 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs4731207 0.596 rs7799518 chr7:124575684 A/C cg23710748 chr7:124431027 NA -0.4 -6.37 -0.33 6.31e-10 Cutaneous malignant melanoma; CRC cis rs801193 0.548 rs2659891 chr7:66201114 A/G cg18252515 chr7:66147081 NA -0.41 -5.83 -0.31 1.34e-8 Aortic root size; CRC cis rs7811142 1.000 rs11763511 chr7:100081944 G/A cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.73 9.87 0.48 2.71e-20 Platelet count; CRC cis rs6951245 1.000 rs80212261 chr7:1114012 C/T cg26224354 chr7:1096374 C7orf50;GPR146 -0.94 -12.2 -0.56 1.65e-28 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC trans rs8002861 0.905 rs6561150 chr13:44460470 C/T cg17145862 chr1:211918768 LPGAT1 0.74 13.81 0.61 1.57e-34 Leprosy; CRC cis rs798554 0.686 rs2644298 chr7:2858448 G/C cg13628971 chr7:2884303 GNA12 0.4 6.19 0.32 1.81e-9 Height; CRC cis rs2180341 0.597 rs11154397 chr6:127646649 G/C cg27446573 chr6:127587934 RNF146 0.62 9.1 0.45 8.79e-18 Breast cancer; CRC cis rs3087591 0.960 rs2953012 chr17:29496486 A/G cg24425628 chr17:29625626 OMG;NF1 0.86 16.37 0.67 1.7e-44 Hip circumference; CRC cis rs17767392 0.958 rs7145755 chr14:71848110 C/T cg13720639 chr14:72061746 SIPA1L1 -0.54 -6.84 -0.35 3.87e-11 Mitral valve prolapse; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg15613982 chr20:18488017 SEC23B 0.42 6.03 0.32 4.41e-9 Response to antipsychotic treatment; CRC cis rs10832963 1.000 rs10128711 chr11:18632984 A/G cg09201001 chr11:18656081 SPTY2D1 0.79 12.35 0.56 4.92e-29 Breast cancer; CRC cis rs11030122 0.547 rs10767720 chr11:3953297 T/C cg18678763 chr11:4115507 RRM1 -0.39 -6.61 -0.34 1.59e-10 Mean platelet volume;Platelet distribution width; CRC trans rs11098499 0.954 rs11940028 chr4:120411907 T/C cg25214090 chr10:38739885 LOC399744 0.66 10.54 0.5 1.46e-22 Corneal astigmatism; CRC cis rs9914988 0.832 rs12946132 chr17:27157362 T/C cg07195577 chr17:27052828 TLCD1 0.41 5.92 0.31 7.89e-9 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs2019137 0.560 rs11123172 chr2:113984303 C/T cg25243455 chr2:114033360 PAX8;LOC440839 0.28 6.66 0.34 1.13e-10 Lymphocyte counts; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg10116431 chr3:143690928 C3orf58 0.38 6.24 0.33 1.33e-9 Liver disease severity in Alagille syndrome; CRC cis rs8058578 1.000 rs7204278 chr16:30730274 A/G cg00531865 chr16:30841666 NA -0.49 -6.74 -0.35 7.31e-11 Multiple myeloma; CRC cis rs2072499 0.750 rs10159384 chr1:156160822 C/T cg24450063 chr1:156163899 SLC25A44 1.07 16.9 0.68 1.41e-46 Testicular germ cell tumor; CRC trans rs7615952 0.932 rs6438948 chr3:125650045 A/T cg00769240 chr8:12517080 NA 0.54 6.88 0.35 3.08e-11 Blood pressure (smoking interaction); CRC trans rs2235573 0.527 rs139883 chr22:38369027 C/T cg19894588 chr14:64061835 NA 0.5 7.38 0.38 1.28e-12 Glioblastoma;Glioma; CRC cis rs8170 1.000 rs66753001 chr19:17394839 A/G cg04749549 chr19:17459798 NA -0.46 -6.18 -0.32 1.9e-9 Breast cancer (estrogen-receptor negative);Breast Cancer in BRCA1 mutation carriers;Ovarian cancer;Breast cancer;Epithelial ovarian cancer; CRC cis rs12188164 0.515 rs17562461 chr5:411361 C/T cg17553881 chr5:443987 EXOC3;C5orf55 -0.31 -6.34 -0.33 7.49e-10 Cystic fibrosis severity; CRC cis rs3785574 0.962 rs2727324 chr17:61922102 G/C cg23090583 chr17:61904693 PSMC5;FTSJ3 0.59 8.41 0.42 1.28e-15 Height; CRC cis rs4908760 0.965 rs10864353 chr1:8549716 A/G cg20416874 chr1:8611966 RERE -0.45 -6.42 -0.33 4.68e-10 Vitiligo; CRC cis rs853679 0.517 rs4713150 chr6:28136212 G/A cg02631126 chr6:28058918 ZSCAN12L1 0.29 5.91 0.31 8.71e-9 Depression; CRC cis rs4665809 0.590 rs4665318 chr2:26424517 C/T cg27170947 chr2:26402098 FAM59B 0.61 7.87 0.4 5.15e-14 Gut microbiome composition (summer); CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg19169234 chr9:128469688 MAPKAP1 0.48 6.36 0.33 6.76e-10 Thyroid stimulating hormone; CRC cis rs77216612 0.877 rs7956514 chr12:12879254 T/G cg04607235 chr12:12878440 APOLD1 -1.01 -13.77 -0.6 2.28e-34 Lymphocyte counts; CRC cis rs6912958 0.500 rs2025486 chr6:87796886 T/C cg04972856 chr6:88032051 C6orf162;GJB7 -0.31 -5.65 -0.3 3.53e-8 Monocyte percentage of white cells; CRC cis rs34375054 0.525 rs7133614 chr12:125605957 C/T cg02766259 chr12:125626809 AACS -0.45 -8.36 -0.42 1.79e-15 Post bronchodilator FEV1/FVC ratio; CRC cis rs9929218 0.861 rs8056206 chr16:68802072 G/C cg02972257 chr16:68554789 NA 0.44 5.63 0.3 3.83e-8 Colorectal cancer; CRC cis rs798554 0.757 rs1182187 chr7:2870454 T/G cg17321639 chr7:2759063 NA -0.52 -6.95 -0.36 2.03e-11 Height; CRC cis rs7258465 1.000 rs8107367 chr19:18564705 A/G cg01065977 chr19:18549689 ISYNA1 -0.42 -6.61 -0.34 1.53e-10 Breast cancer; CRC cis rs11758351 0.866 rs56186759 chr6:26207181 C/T cg10723962 chr6:26240782 HIST1H4F -0.38 -6.31 -0.33 8.85e-10 Gout;Renal underexcretion gout; CRC trans rs11039798 0.687 rs11499938 chr11:48957297 G/A cg03929089 chr4:120376271 NA 0.64 6.02 0.31 4.77e-9 Axial length; CRC cis rs7635838 0.751 rs9811658 chr3:11395833 A/G cg00170343 chr3:11313890 ATG7 0.44 6.67 0.34 1.12e-10 HDL cholesterol; CRC cis rs9916302 0.904 rs8066704 chr17:37477218 C/T cg15445000 chr17:37608096 MED1 -0.43 -9.65 -0.47 1.47e-19 Glomerular filtration rate (creatinine); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg20273122 chr11:68671309 IGHMBP2;MRPL21 0.38 6.06 0.32 3.77e-9 Liver disease severity in Alagille syndrome; CRC trans rs11039798 0.588 rs643668 chr11:48413399 C/G cg03929089 chr4:120376271 NA -0.64 -7.03 -0.36 1.16e-11 Axial length; CRC trans rs6076960 0.684 rs6054059 chr20:6262472 G/T cg17788362 chr6:86352627 SYNCRIP 0.56 7.85 0.4 5.85e-14 Smooth-surface caries; CRC trans rs9291683 0.509 rs10939671 chr4:10050815 T/C cg26043149 chr18:55253948 FECH 0.51 7.76 0.39 1.05e-13 Bone mineral density; CRC trans rs12599106 0.818 rs17723574 chr16:34602945 C/G cg05064044 chr6:292385 DUSP22 -0.56 -7.97 -0.4 2.68e-14 Menopause (age at onset); CRC cis rs826838 1.000 rs826851 chr12:39112639 A/G cg26384229 chr12:38710491 ALG10B -0.63 -9.66 -0.47 1.33e-19 Heart rate; CRC cis rs904251 0.605 rs4257849 chr6:37410969 T/G cg25019722 chr6:37503610 NA -0.4 -5.85 -0.31 1.21e-8 Cognitive performance; CRC trans rs12517041 1.000 rs35753092 chr5:23277623 G/T ch.8.1293020R chr8:59333349 UBXN2B -0.55 -6.14 -0.32 2.38e-9 Calcium levels; CRC cis rs875971 0.755 rs76288834 chr7:66069802 G/A cg18252515 chr7:66147081 NA 0.43 6.0 0.31 5.18e-9 Aortic root size; CRC cis rs9875589 0.957 rs1108341 chr3:13937328 T/A cg19554555 chr3:13937349 NA 0.51 7.3 0.37 2.24e-12 Ovarian reserve; CRC cis rs335206 1.000 rs335204 chr5:122506260 C/A cg16368670 chr5:122501738 PRDM6 -0.29 -5.71 -0.3 2.5e-8 QRS duration; CRC cis rs172166 0.637 rs1225595 chr6:28151340 A/T cg23161317 chr6:28129485 ZNF389 0.47 6.73 0.35 7.5e-11 Cardiac Troponin-T levels; CRC cis rs17401966 0.522 rs2027330 chr1:10275592 C/T cg19773385 chr1:10388646 KIF1B -0.49 -7.76 -0.39 1.06e-13 Hepatocellular carcinoma; CRC cis rs4481887 0.639 rs10749644 chr1:248414587 A/C cg00666640 chr1:248458726 OR2T12 0.49 8.73 0.43 1.34e-16 Common traits (Other); CRC cis rs9443645 0.869 rs9448591 chr6:79606490 C/T cg05283184 chr6:79620031 NA -0.58 -9.37 -0.46 1.21e-18 Intelligence (multi-trait analysis); CRC cis rs1568889 0.838 rs7125749 chr11:28154692 A/T cg06544937 chr11:28130018 METT5D1;KIF18A 0.92 15.5 0.65 4.47e-41 Bipolar disorder; CRC cis rs13191362 1.000 rs13210412 chr6:163019478 T/C cg21926612 chr6:163149169 PACRG;PARK2 0.77 11.07 0.52 2e-24 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs9527 0.615 rs1556960 chr10:104726673 A/G cg15744005 chr10:104629667 AS3MT -0.31 -6.18 -0.32 1.86e-9 Arsenic metabolism; CRC cis rs2040771 0.804 rs7286849 chr22:19223579 C/A cg02655711 chr22:19163373 SLC25A1 0.51 8.46 0.42 8.96e-16 Metabolite levels (small molecules and protein measures); CRC cis rs8180040 0.764 rs4082155 chr3:47125385 G/A cg02527881 chr3:46936655 PTH1R -0.4 -7.42 -0.38 1.02e-12 Colorectal cancer; CRC cis rs977987 0.815 rs11149821 chr16:75422817 C/T cg03315344 chr16:75512273 CHST6 0.54 9.12 0.45 7.5e-18 Dupuytren's disease; CRC cis rs1865760 0.964 rs6932113 chr6:25913098 C/T cg17691542 chr6:26056736 HIST1H1C 0.56 8.41 0.42 1.25e-15 Height; CRC cis rs728616 0.867 rs79904324 chr10:81804688 A/G cg05935833 chr10:81318306 SFTPA2 -0.58 -6.82 -0.35 4.41e-11 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs7923609 1.000 rs10822161 chr10:65118203 G/A cg08743896 chr10:65200160 JMJD1C -0.4 -5.74 -0.3 2.11e-8 Educational attainment;Liver enzyme levels (alkaline phosphatase); CRC cis rs7264396 0.563 rs2425081 chr20:34299733 C/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.48 -6.67 -0.35 1.06e-10 Total cholesterol levels; CRC cis rs9911578 1.000 rs302848 chr17:56686454 C/T cg05425664 chr17:57184151 TRIM37 -0.5 -7.87 -0.4 5.13e-14 Intelligence (multi-trait analysis); CRC cis rs34779708 0.966 rs7070427 chr10:35485689 A/T cg03585969 chr10:35415529 CREM 0.54 7.32 0.37 1.88e-12 Inflammatory bowel disease;Crohn's disease; CRC cis rs11155671 0.530 rs1334510 chr6:150201179 A/G cg19673125 chr6:150240577 RAET1G 0.3 5.8 0.3 1.58e-8 Testicular germ cell tumor; CRC cis rs2404602 0.583 rs35707798 chr15:76565026 G/C cg00316803 chr15:76480434 C15orf27 -0.4 -6.9 -0.36 2.63e-11 Blood metabolite levels; CRC cis rs7666738 0.830 rs7662389 chr4:99019892 G/A cg05340658 chr4:99064831 C4orf37 0.63 9.84 0.48 3.47e-20 Colonoscopy-negative controls vs population controls; CRC cis rs6499255 0.951 rs9921045 chr16:69708698 C/T cg04110750 chr16:69646130 NFAT5 -0.56 -7.74 -0.39 1.22e-13 IgE levels; CRC trans rs2303319 0.504 rs62189043 chr2:162608466 A/T cg09481857 chr22:21368659 P2RX6;MGC16703 -0.65 -6.31 -0.33 9.13e-10 Cognitive function; CRC cis rs801193 0.569 rs2013908 chr7:66121069 A/T cg18876405 chr7:65276391 NA -0.5 -8.05 -0.41 1.5e-14 Aortic root size; CRC cis rs6066835 0.867 rs6095278 chr20:47363413 C/T cg18078177 chr20:47281410 PREX1 0.63 5.89 0.31 9.41e-9 Multiple myeloma; CRC trans rs7618501 0.966 rs9882639 chr3:49799475 A/C cg21665057 chr3:196295764 WDR53;FBXO45 0.86 15.79 0.66 3.5e-42 Intelligence (multi-trait analysis); CRC cis rs9393692 0.645 rs28446029 chr6:26305801 C/G cg13736514 chr6:26305472 NA -0.68 -11.83 -0.55 3.77e-27 Educational attainment; CRC cis rs6952808 0.792 rs34269264 chr7:1948712 C/T cg22963979 chr7:1858916 MAD1L1 -0.51 -7.52 -0.38 5.38e-13 Bipolar disorder and schizophrenia; CRC cis rs6952808 0.760 rs11764960 chr7:1950532 G/A cg22963979 chr7:1858916 MAD1L1 -0.5 -7.26 -0.37 2.78e-12 Bipolar disorder and schizophrenia; CRC cis rs2032447 0.702 rs199753 chr6:26001888 G/A cg03517284 chr6:25882590 NA -0.57 -7.68 -0.39 1.78e-13 Intelligence (multi-trait analysis); CRC cis rs7772486 0.686 rs7744014 chr6:146123818 G/A cg05347473 chr6:146136440 FBXO30 0.37 5.63 0.3 3.78e-8 Lobe attachment (rater-scored or self-reported); CRC cis rs6087990 0.806 rs6088008 chr20:31382860 A/G cg13636640 chr20:31349939 DNMT3B 0.79 15.34 0.65 1.96e-40 Ulcerative colitis; CRC cis rs10504229 0.639 rs67002486 chr8:58117218 A/G cg22535103 chr8:58192502 C8orf71 -0.7 -9.34 -0.46 1.47e-18 Developmental language disorder (linguistic errors); CRC cis rs2274273 0.624 rs66551709 chr14:55791022 A/T cg10130446 chr14:55658398 DLGAP5 -0.41 -5.77 -0.3 1.79e-8 Protein biomarker; CRC cis rs4332037 0.539 rs55790766 chr7:2021248 C/T cg25834613 chr7:1915315 MAD1L1 -0.47 -6.79 -0.35 5.26e-11 Bipolar disorder; CRC trans rs11039798 0.841 rs7950737 chr11:48590678 T/G cg15704280 chr7:45808275 SEPT13 0.62 5.98 0.31 5.71e-9 Axial length; CRC cis rs40363 0.645 rs6501177 chr16:3523681 C/T cg05754148 chr16:3507555 NAT15 0.47 6.54 0.34 2.29e-10 Tuberculosis; CRC cis rs9858542 0.953 rs9862080 chr3:49674458 A/G cg07274523 chr3:49395745 GPX1 0.46 5.93 0.31 7.77e-9 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs10078 0.571 rs2721014 chr5:463539 G/A cg07599136 chr5:415885 AHRR 0.71 7.04 0.36 1.1e-11 Fat distribution (HIV); CRC trans rs3733585 0.699 rs4473653 chr4:9971058 A/G cg26043149 chr18:55253948 FECH -0.48 -7.32 -0.37 1.95e-12 Cleft plate (environmental tobacco smoke interaction); CRC cis rs736408 0.688 rs2239551 chr3:52818579 A/G cg18404041 chr3:52824283 ITIH1 0.44 9.03 0.45 1.49e-17 Bipolar disorder; CRC cis rs908922 0.676 rs526099 chr1:152497811 T/C cg09873164 chr1:152488093 CRCT1 0.37 6.22 0.32 1.49e-9 Hair morphology; CRC cis rs12681287 0.640 rs7841690 chr8:87365359 T/C cg27223183 chr8:87520930 FAM82B 0.53 7.19 0.37 4.51e-12 Caudate activity during reward; CRC cis rs6496667 0.779 rs2283442 chr15:90971478 C/G cg04176472 chr15:90893244 GABARAPL3 0.6 8.29 0.42 2.86e-15 Rheumatoid arthritis; CRC cis rs12477438 0.501 rs2632284 chr2:99775865 C/G cg14399236 chr2:99771627 LIPT1;TSGA10 0.82 14.56 0.63 2.05e-37 Chronic sinus infection; CRC trans rs6703335 0.870 rs10803142 chr1:243598234 A/G cg26114003 chr2:25016152 CENPO;C2orf79 0.44 6.17 0.32 1.98e-9 Schizophrenia;Schizophrenia, schizoaffective disorder or bipolar disorder; CRC cis rs6582630 0.638 rs1829584 chr12:38526299 G/T cg26384229 chr12:38710491 ALG10B -0.54 -7.85 -0.4 5.85e-14 Drug-induced liver injury (flucloxacillin); CRC cis rs9733 0.596 rs12403255 chr1:150660412 C/T cg10589385 chr1:150898437 SETDB1 0.28 5.97 0.31 6.28e-9 Tonsillectomy; CRC cis rs1401999 0.966 rs2292998 chr3:183663833 T/C cg20387954 chr3:183756860 HTR3D 0.45 7.67 0.39 1.91e-13 Anterior chamber depth; CRC cis rs4664293 1.000 rs2357382 chr2:160493125 G/C cg08347373 chr2:160653686 CD302 -0.38 -6.24 -0.33 1.38e-9 Monocyte percentage of white cells; CRC cis rs1997103 0.911 rs17777 chr7:55380765 T/C cg17469321 chr7:55412551 NA 0.74 11.39 0.53 1.5e-25 QRS interval (sulfonylurea treatment interaction); CRC trans rs208520 0.874 rs208470 chr6:66916402 G/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.89 -11.73 -0.54 8.43e-27 Exhaled nitric oxide output; CRC cis rs6951245 1.000 rs74887741 chr7:1110658 G/T cg04025307 chr7:1156635 C7orf50 0.65 6.94 0.36 2.03e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs9858542 0.953 rs9814873 chr3:49454112 A/G cg07274523 chr3:49395745 GPX1 0.46 6.26 0.33 1.19e-9 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs3204270 0.810 rs8077959 chr17:79670122 G/A cg18367735 chr17:79674897 NA 0.51 5.88 0.31 9.94e-9 Dental caries; CRC cis rs7223966 1.000 rs7220892 chr17:61908316 G/A cg23090583 chr17:61904693 PSMC5;FTSJ3 0.53 6.57 0.34 1.95e-10 Hip circumference adjusted for BMI;Body mass index; CRC cis rs6424115 0.830 rs1130320 chr1:24200606 A/G cg10978503 chr1:24200527 CNR2 0.61 11.06 0.52 2.22e-24 Immature fraction of reticulocytes; CRC cis rs9322193 0.884 rs11155675 chr6:150064019 T/C cg00933542 chr6:150070202 PCMT1 0.31 6.11 0.32 2.75e-9 Lung cancer; CRC cis rs8060686 0.920 rs73594556 chr16:67925435 G/A cg07125278 chr16:67683757 RLTPR -0.63 -7.25 -0.37 3.09e-12 HDL cholesterol;Metabolic syndrome; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg17602823 chr1:28586543 SESN2 0.43 6.92 0.36 2.38e-11 Liver disease severity in Alagille syndrome; CRC cis rs35306767 0.903 rs11253488 chr10:922482 G/C cg26597838 chr10:835615 NA 0.97 11.95 0.55 1.37e-27 Eosinophil percentage of granulocytes; CRC cis rs4680 1.000 rs165656 chr22:19948863 C/G cg23601416 chr22:19950040 COMT -0.26 -7.15 -0.37 5.79e-12 Blood metabolite levels; CRC cis rs7927592 0.763 rs7119422 chr11:68331154 C/T cg16797656 chr11:68205561 LRP5 -0.46 -8.44 -0.42 1.01e-15 Total body bone mineral density; CRC cis rs10883723 0.810 rs7917525 chr10:104246755 C/G cg22532475 chr10:104410764 TRIM8 -0.36 -6.66 -0.34 1.18e-10 Allergic disease (asthma, hay fever or eczema); CRC cis rs4713118 0.869 rs9283880 chr6:27715243 A/C cg03623178 chr6:28175578 NA 0.67 9.51 0.46 4.25e-19 Parkinson's disease; CRC trans rs637571 0.510 rs10896052 chr11:65579600 C/A cg17712092 chr4:129076599 LARP1B -0.55 -8.4 -0.42 1.37e-15 Eosinophil percentage of white cells; CRC cis rs10193935 1.000 rs10173107 chr2:42420302 A/T cg27598129 chr2:42591480 NA -0.74 -8.09 -0.41 1.19e-14 Colonoscopy-negative controls vs population controls; CRC trans rs7937682 0.889 rs541198 chr11:111475340 A/G cg18187862 chr3:45730750 SACM1L 0.45 6.55 0.34 2.23e-10 Primary sclerosing cholangitis; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg13405485 chr10:13628859 PRPF18 0.39 6.46 0.34 3.81e-10 Liver disease severity in Alagille syndrome; CRC cis rs56307353 0.753 rs34318825 chr19:1961342 T/C cg26776924 chr19:1969666 CSNK1G2 0.46 7.36 0.38 1.51e-12 Coronary artery disease; CRC cis rs10089 0.951 rs736969 chr5:127466347 G/C cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.72 9.97 0.48 1.29e-20 Ileal carcinoids; CRC trans rs10504390 0.585 rs79812520 chr8:66507615 T/C cg26403416 chr21:43771339 TFF2 0.64 6.54 0.34 2.37e-10 IgG glycosylation; CRC cis rs9409565 0.826 rs2139189 chr9:97238538 A/G cg04523069 chr9:97136363 HIATL1 0.37 5.77 0.3 1.8e-8 Colorectal cancer (alcohol consumption interaction); CRC cis rs9443645 0.507 rs9352633 chr6:79462623 C/G cg05283184 chr6:79620031 NA -0.44 -7.32 -0.37 1.89e-12 Intelligence (multi-trait analysis); CRC cis rs10540 0.908 rs12792111 chr11:520921 G/C cg03576123 chr11:487126 PTDSS2 -1.04 -10.72 -0.51 3.38e-23 Body mass index; CRC cis rs9868809 0.505 rs13063223 chr3:48750340 G/A cg00383909 chr3:49044727 WDR6 0.79 8.04 0.41 1.68e-14 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; CRC cis rs4862750 0.872 rs7679956 chr4:187900229 C/T cg06074448 chr4:187884817 NA -0.63 -12.18 -0.56 2.04e-28 Lobe attachment (rater-scored or self-reported); CRC trans rs2243480 1.000 rs2460422 chr7:65601505 C/T cg10756647 chr7:56101905 PSPH 0.74 7.72 0.39 1.43e-13 Diabetic kidney disease; CRC cis rs933688 1.000 rs35712350 chr5:90679519 C/T cg02339078 chr5:90679543 LOC100129716;ARRDC3 0.97 15.72 0.65 6.17e-42 Smoking behavior; CRC trans rs79976124 0.879 rs12213669 chr6:66627704 G/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.76 9.54 0.47 3.31e-19 Type 2 diabetes; CRC cis rs921968 0.643 rs832806 chr2:219473914 A/T cg02176678 chr2:219576539 TTLL4 0.5 7.86 0.4 5.48e-14 Mean corpuscular hemoglobin concentration; CRC cis rs9926296 0.568 rs7203907 chr16:89833774 C/G cg03388025 chr16:89894329 SPIRE2 0.42 8.29 0.42 2.9e-15 Vitiligo; CRC cis rs939584 1.000 rs13021737 chr2:632348 A/G cg03610516 chr2:642275 NA 0.42 5.64 0.3 3.58e-8 Body mass index; CRC cis rs6952808 0.825 rs34296663 chr7:1935245 C/T cg21782813 chr7:2030301 MAD1L1 0.46 7.97 0.4 2.6e-14 Bipolar disorder and schizophrenia; CRC cis rs12024301 0.557 rs80013399 chr1:183598837 T/C cg11505048 chr1:183622726 RGL1;APOBEC4 0.76 6.93 0.36 2.16e-11 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs7945705 0.902 rs2016942 chr11:8938787 A/G cg21881798 chr11:8931708 C11orf17;ST5 0.68 10.39 0.5 4.84e-22 Hemoglobin concentration; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg17727855 chr9:108007124 SLC44A1 -0.4 -6.15 -0.32 2.21e-9 Myopia (pathological); CRC cis rs10512697 0.803 rs13177899 chr5:3578923 T/C cg19473799 chr5:3511975 NA -0.73 -5.8 -0.3 1.53e-8 Immune response to smallpox vaccine (IL-6); CRC cis rs6502050 0.777 rs11077969 chr17:80085633 A/G cg25804541 chr17:80189381 SLC16A3 0.31 5.9 0.31 8.94e-9 Life satisfaction; CRC cis rs9322193 0.923 rs9322200 chr6:149951214 G/A cg00933542 chr6:150070202 PCMT1 0.29 6.12 0.32 2.69e-9 Lung cancer; CRC cis rs9303401 0.538 rs8078280 chr17:56473132 A/G cg02118635 chr17:56770003 RAD51C;TEX14 0.7 8.68 0.43 1.83e-16 Cognitive test performance; CRC trans rs11343 0.675 rs7359333 chr16:19262344 A/T cg18100827 chr3:119013497 CDGAP -0.47 -5.99 -0.31 5.62e-9 Parkinson's disease; CRC cis rs12594515 1.000 rs8038320 chr15:45990267 G/C cg06207120 chr15:45996521 NA 0.32 7.75 0.39 1.14e-13 Waist circumference;Weight; CRC trans rs246600 0.543 rs246607 chr5:142513686 C/T cg16052198 chr19:52264411 FPR2 -0.32 -6.34 -0.33 7.44e-10 Coronary artery disease; CRC cis rs2252521 0.666 rs1117873 chr7:29086980 T/C cg11728747 chr7:29037910 CPVL -0.33 -6.04 -0.32 4.27e-9 Cognitive performance; CRC cis rs501120 1.000 rs634963 chr10:44760033 T/C cg09554077 chr10:44749378 NA 0.78 11.96 0.55 1.33e-27 Coronary artery disease;Coronary heart disease; CRC cis rs7412746 0.658 rs59024312 chr1:150909005 T/G cg15448220 chr1:150897856 SETDB1 0.56 8.23 0.41 4.44e-15 Melanoma; CRC cis rs7771547 0.519 rs9654588 chr6:36363923 A/C cg07856975 chr6:36356162 ETV7 0.48 5.98 0.31 5.7e-9 Platelet distribution width; CRC cis rs9914988 0.943 rs4794839 chr17:27131393 G/A cg20469991 chr17:27169893 C17orf63 -0.6 -7.27 -0.37 2.59e-12 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs3785574 0.962 rs2665842 chr17:61878535 G/A cg22520471 chr17:61851767 DDX42;CCDC47 0.47 6.52 0.34 2.63e-10 Height; CRC cis rs9611565 0.802 rs9611571 chr22:41784867 G/A cg03806693 chr22:41940476 POLR3H -0.99 -12.74 -0.57 1.64e-30 Vitiligo; CRC cis rs13108904 0.517 rs13128825 chr4:1334007 G/A cg00684032 chr4:1343700 KIAA1530 0.58 8.18 0.41 6.4e-15 Obesity-related traits; CRC cis rs939584 0.877 rs7594220 chr2:643320 G/A cg03610516 chr2:642275 NA 0.42 5.88 0.31 9.94e-9 Body mass index; CRC cis rs2230307 0.536 rs6677998 chr1:100461046 G/A cg24955406 chr1:100503596 HIAT1 0.58 7.0 0.36 1.45e-11 Carotid intima media thickness; CRC cis rs9291683 0.588 rs17246745 chr4:9994583 T/C cg00071950 chr4:10020882 SLC2A9 0.63 11.9 0.55 2.08e-27 Bone mineral density; CRC cis rs3018066 0.831 rs11732791 chr4:107157238 T/C cg01869342 chr4:106983673 TBCK -0.36 -5.64 -0.3 3.66e-8 Cancer; CRC cis rs6960043 1.000 rs12113083 chr7:15051943 G/C cg19272540 chr7:15055459 NA -0.22 -5.7 -0.3 2.67e-8 Type 2 diabetes; CRC cis rs637571 0.584 rs594689 chr11:65635559 G/A cg04055107 chr11:65626734 MUS81;CFL1 -0.45 -6.52 -0.34 2.72e-10 Eosinophil percentage of white cells; CRC cis rs9487051 0.837 rs1915834 chr6:109597624 C/A cg01475377 chr6:109611718 NA -0.47 -8.84 -0.44 6.04e-17 Reticulocyte fraction of red cells; CRC cis rs1707322 1.000 rs11211200 chr1:46288352 A/G cg06784218 chr1:46089804 CCDC17 0.5 8.85 0.44 5.45e-17 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg20252735 chr7:56019475 MRPS17 0.41 6.03 0.32 4.48e-9 Response to antipsychotic treatment; CRC cis rs614226 0.938 rs787824 chr12:120924638 A/G cg27489772 chr12:121021490 NA -0.47 -6.59 -0.34 1.72e-10 Type 1 diabetes nephropathy; CRC cis rs8014204 0.816 rs11159107 chr14:75341266 C/A cg03030879 chr14:75389066 RPS6KL1 0.44 7.03 0.36 1.19e-11 Caffeine consumption; CRC cis rs7666738 0.830 rs6827516 chr4:98971740 T/C cg05340658 chr4:99064831 C4orf37 0.6 9.35 0.46 1.41e-18 Colonoscopy-negative controls vs population controls; CRC cis rs78456975 0.943 rs7602369 chr2:1574754 T/C cg12573674 chr2:1569213 NA -0.68 -7.56 -0.38 3.95e-13 Placebo response in major depressive disorder (% change in symptom score); CRC cis rs919433 0.889 rs6711624 chr2:198207607 C/G cg10820045 chr2:198174542 NA -0.5 -8.67 -0.43 1.97e-16 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC cis rs10540 1.000 rs67912009 chr11:495057 G/T cg03352830 chr11:487213 PTDSS2 0.66 8.29 0.42 2.99e-15 Body mass index; CRC cis rs6502050 0.842 rs8080305 chr17:80074516 A/C cg02741985 chr17:80059408 CCDC57 -0.45 -7.38 -0.38 1.34e-12 Life satisfaction; CRC cis rs10197940 0.578 rs2045025 chr2:152317531 T/C cg06191203 chr2:152266755 RIF1 -0.45 -6.31 -0.33 8.86e-10 Lung cancer; CRC cis rs2180341 0.781 rs7742161 chr6:127571676 T/C cg27446573 chr6:127587934 RNF146 0.75 11.18 0.52 8.28e-25 Breast cancer; CRC trans rs4869931 0.929 rs73010188 chr6:151006620 T/C cg01367992 chr1:160766535 LY9 0.37 6.06 0.32 3.76e-9 Systolic blood pressure in sickle cell anemia; CRC trans rs1600249 0.562 rs17153419 chr8:11394233 C/T cg06636001 chr8:8085503 FLJ10661 -0.48 -6.31 -0.33 9.11e-10 Rheumatoid arthritis; CRC cis rs8067545 0.611 rs2703788 chr17:20159686 T/C cg13482628 chr17:19912719 NA -0.48 -7.6 -0.39 3.03e-13 Schizophrenia; CRC cis rs3018066 0.831 rs28394440 chr4:106944126 C/A cg01869342 chr4:106983673 TBCK 0.39 6.02 0.31 4.75e-9 Cancer; CRC cis rs61774743 0.681 rs10889959 chr1:41849735 T/C cg08462924 chr1:41848221 NA 0.4 6.19 0.32 1.83e-9 Intelligence (multi-trait analysis); CRC cis rs561341 1.000 rs117029332 chr17:30266085 C/G cg12193833 chr17:30244370 NA -0.75 -8.76 -0.43 1.09e-16 Hip circumference adjusted for BMI; CRC cis rs6502050 0.835 rs7213172 chr17:80085703 G/T cg09264619 chr17:80180166 NA 0.36 6.08 0.32 3.4e-9 Life satisfaction; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg07499643 chr1:43424067 SLC2A1 0.43 6.36 0.33 6.84e-10 Intelligence (multi-trait analysis); CRC cis rs12594515 1.000 rs8038058 chr15:45990272 C/T cg19682013 chr15:45996608 NA 0.32 6.68 0.35 1.01e-10 Waist circumference;Weight; CRC cis rs13191362 1.000 rs34773528 chr6:163088796 G/C cg06582575 chr6:163149167 PACRG;PARK2 0.93 11.67 0.54 1.44e-26 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs832187 0.813 rs704370 chr3:63868250 A/G cg16258503 chr3:63850278 ATXN7;THOC7 0.4 5.72 0.3 2.41e-8 Schizophrenia; CRC cis rs2051211 0.895 rs17037798 chr3:38555474 G/A cg01465620 chr3:38496096 LOC100128640;ACVR2B -0.46 -5.77 -0.3 1.83e-8 QRS duration; CRC cis rs9616064 0.670 rs9616045 chr22:46949292 C/T cg05621596 chr22:47072043 GRAMD4 -0.56 -8.43 -0.42 1.11e-15 Urate levels in obese individuals; CRC cis rs9902453 0.765 rs1531553 chr17:28066752 T/C cg26525008 chr17:28256777 EFCAB5;SSH2 -0.72 -12.04 -0.55 6.79e-28 Coffee consumption (cups per day); CRC cis rs534126 1.000 rs534126 chr7:142921234 C/T cg04039957 chr7:143013207 CLCN1 0.37 6.48 0.34 3.37e-10 Cancer; CRC cis rs72945132 0.882 rs56368190 chr11:70204328 T/G cg00319359 chr11:70116639 PPFIA1 0.56 6.11 0.32 2.76e-9 Coronary artery disease; CRC cis rs9549260 0.564 rs9315784 chr13:41289166 G/A cg21288729 chr13:41239152 FOXO1 0.41 6.28 0.33 1.05e-9 Red blood cell count; CRC cis rs7493 0.755 rs740264 chr7:95021803 T/G cg20119798 chr7:94954144 PON1 -0.46 -5.69 -0.3 2.78e-8 Yu-Zhi constitution type in type 2 diabetes; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg25976393 chr20:34680652 NA 0.42 6.39 0.33 5.72e-10 Anxiety disorder; CRC cis rs3785574 0.962 rs2727329 chr17:61924566 C/T cg23090583 chr17:61904693 PSMC5;FTSJ3 0.63 9.0 0.44 1.85e-17 Height; CRC cis rs1552244 1.000 rs7611218 chr3:10063960 T/C cg10729496 chr3:10149963 C3orf24 0.5 6.71 0.35 8.29e-11 Alzheimer's disease; CRC cis rs62064224 0.589 rs2344976 chr17:30685935 T/C cg21839984 chr17:30846986 MYO1D -0.35 -6.07 -0.32 3.46e-9 Schizophrenia; CRC cis rs7264396 0.790 rs3787166 chr20:34229072 A/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.52 -8.33 -0.42 2.25e-15 Total cholesterol levels; CRC cis rs6952808 0.723 rs4721287 chr7:2028663 A/C cg02951883 chr7:2050386 MAD1L1 -0.78 -12.8 -0.58 1.04e-30 Bipolar disorder and schizophrenia; CRC cis rs7811142 1.000 rs7794485 chr7:100068936 T/C cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.72 9.25 0.45 2.83e-18 Platelet count; CRC cis rs10504229 0.683 rs7843919 chr8:58130792 T/C cg02725872 chr8:58115012 NA -0.64 -11.55 -0.54 3.85e-26 Developmental language disorder (linguistic errors); CRC cis rs11098499 0.575 rs9996586 chr4:120326942 A/G cg09307838 chr4:120376055 NA 0.54 8.3 0.42 2.8e-15 Corneal astigmatism; CRC cis rs1799949 0.931 rs9912203 chr17:41445145 A/G cg05368731 chr17:41323189 NBR1 -0.62 -9.67 -0.47 1.22e-19 Menopause (age at onset); CRC cis rs3733585 0.605 rs4235354 chr4:10122942 C/A cg00071950 chr4:10020882 SLC2A9 -0.56 -8.78 -0.44 8.82e-17 Cleft plate (environmental tobacco smoke interaction); CRC trans rs2303319 0.504 rs16846073 chr2:162586548 C/G cg04551154 chr10:95462393 C10orf4 -0.69 -5.96 -0.31 6.38e-9 Cognitive function; CRC cis rs1030877 0.515 rs3828300 chr2:105901107 G/A cg02079111 chr2:105885981 TGFBRAP1 -0.47 -5.82 -0.31 1.41e-8 Obesity-related traits; CRC trans rs2727020 0.658 rs4980442 chr11:49445016 G/T cg03929089 chr4:120376271 NA -0.87 -16.07 -0.66 2.79e-43 Coronary artery disease; CRC cis rs7726839 0.540 rs72703079 chr5:595173 T/C cg09021430 chr5:549028 NA -0.7 -8.17 -0.41 6.68e-15 Obesity-related traits; CRC cis rs3768617 0.811 rs34721094 chr1:183051521 T/C ch.1.3577855R chr1:183094577 LAMC1 0.64 9.45 0.46 6.58e-19 Fuchs's corneal dystrophy; CRC cis rs6952808 0.689 rs871924 chr7:2047845 A/G cg19624444 chr7:2048497 MAD1L1 0.33 5.9 0.31 8.96e-9 Bipolar disorder and schizophrenia; CRC cis rs501916 0.634 rs10851459 chr15:48061510 C/A cg16110827 chr15:48056943 SEMA6D -0.45 -6.62 -0.34 1.43e-10 Inflammatory bowel disease;Ulcerative colitis; CRC cis rs7762018 0.607 rs3800544 chr6:170058374 C/T cg19338460 chr6:170058176 WDR27 -1.07 -10.58 -0.5 1.03e-22 Thiazide-induced adverse metabolic effects in hypertensive patients; CRC cis rs11148252 0.716 rs3803262 chr13:53036398 A/G cg02158880 chr13:53174818 NA 0.49 7.4 0.38 1.13e-12 Lewy body disease; CRC cis rs11214589 0.774 rs7116782 chr11:113250938 A/G cg14159747 chr11:113255604 NA 0.61 12.42 0.57 2.58e-29 Neuroticism; CRC cis rs1448094 0.967 rs7301496 chr12:86321212 A/C cg18827107 chr12:86230957 RASSF9 -0.37 -6.12 -0.32 2.61e-9 Major depressive disorder; CRC cis rs546131 0.928 rs552868 chr11:34830694 G/A cg24088639 chr11:34937564 PDHX;APIP -0.45 -6.34 -0.33 7.54e-10 Lung disease severity in cystic fibrosis; CRC cis rs7945718 0.967 rs12417886 chr11:12811731 A/C cg25843174 chr11:12811716 TEAD1 -0.51 -9.7 -0.47 9.88e-20 Educational attainment (years of education); CRC cis rs10751667 0.666 rs7395267 chr11:962326 C/A ch.11.42038R chr11:967971 AP2A2 0.58 9.98 0.48 1.16e-20 Alzheimer's disease (late onset); CRC cis rs2354432 0.607 rs7511989 chr1:146720160 A/G cg25205988 chr1:146714368 CHD1L -1.17 -9.75 -0.47 6.94e-20 Mitochondrial DNA levels; CRC cis rs8103278 0.507 rs3745802 chr19:46271177 G/T cg14061069 chr19:46274453 DMPK 0.69 12.96 0.58 2.64e-31 Coronary artery disease; CRC trans rs10983614 1.000 rs7867776 chr9:120072627 A/G cg03430067 chr19:14016927 C19orf57;CC2D1A 0.48 6.43 0.33 4.61e-10 Survival in pancreatic cancer; CRC cis rs6456156 0.774 rs9347175 chr6:167527644 A/T cg05540913 chr6:167530185 CCR6 -0.39 -7.14 -0.37 6.07e-12 Primary biliary cholangitis; CRC cis rs7618915 0.547 rs2878726 chr3:52748271 C/G cg11645453 chr3:52864694 ITIH4 0.36 6.31 0.33 8.84e-10 Bipolar disorder; CRC cis rs748404 0.631 rs6493086 chr15:43655394 T/C cg02155558 chr15:43621948 ADAL;LCMT2 0.54 7.87 0.4 5.21e-14 Lung cancer; CRC cis rs9814567 0.806 rs12637301 chr3:134317966 G/T cg06541857 chr3:134203789 ANAPC13;CEP63 -0.37 -5.73 -0.3 2.3e-8 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs4253772 0.513 rs6008597 chr22:46703904 A/C cg24881330 chr22:46731750 TRMU 0.6 6.87 0.35 3.31e-11 LDL cholesterol;Cholesterol, total; CRC cis rs6860806 0.531 rs2631359 chr5:131707892 C/T cg20512303 chr5:131592959 PDLIM4 -0.39 -6.69 -0.35 9.68e-11 Breast cancer; CRC cis rs8180040 0.934 rs4858811 chr3:47480524 G/C cg10298567 chr3:47292165 KIF9 0.37 5.98 0.31 5.68e-9 Colorectal cancer; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg11961288 chr19:45681945 BLOC1S3;TRAPPC6A 0.45 6.44 0.33 4.12e-10 Response to antipsychotic treatment; CRC cis rs10504229 1.000 rs72650885 chr8:58175131 G/A cg22535103 chr8:58192502 C8orf71 -0.82 -12.27 -0.56 9.63e-29 Developmental language disorder (linguistic errors); CRC cis rs6662572 0.737 rs72677545 chr1:46571221 C/T cg08644498 chr1:46502608 NA 0.46 7.36 0.38 1.45e-12 Blood protein levels; CRC cis rs7607369 0.536 rs12990447 chr2:219667413 T/C cg02176678 chr2:219576539 TTLL4 -0.37 -5.92 -0.31 7.91e-9 Red blood cell count;Amyotrophic lateral sclerosis; CRC cis rs9527 0.590 rs10883836 chr10:104891198 T/C cg15744005 chr10:104629667 AS3MT -0.31 -6.1 -0.32 3.03e-9 Arsenic metabolism; CRC cis rs1862618 0.715 rs6866779 chr5:56090000 G/A cg03609598 chr5:56110824 MAP3K1 -0.81 -9.7 -0.47 1.01e-19 Initial pursuit acceleration; CRC cis rs6964587 0.626 rs9008 chr7:91502407 C/G cg17063962 chr7:91808500 NA -0.6 -9.5 -0.46 4.44e-19 Breast cancer; CRC cis rs853679 0.550 rs1233704 chr6:28166923 A/G cg02683197 chr6:28174875 NA -0.89 -12.67 -0.57 3.01e-30 Depression; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg10349436 chr2:106015079 FHL2 0.41 6.42 0.33 4.7e-10 Liver disease severity in Alagille syndrome; CRC cis rs4713118 0.513 rs149972 chr6:27983227 C/T cg12273811 chr6:28175739 NA 0.59 8.61 0.43 3.11e-16 Parkinson's disease; CRC cis rs28386778 0.897 rs8077013 chr17:61850392 C/T cg22520471 chr17:61851767 DDX42;CCDC47 0.74 11.57 0.54 3.22e-26 Prudent dietary pattern; CRC cis rs4731207 0.596 rs6466966 chr7:124580327 A/G cg23710748 chr7:124431027 NA 0.38 6.12 0.32 2.7e-9 Cutaneous malignant melanoma; CRC cis rs11190604 1.000 rs11190570 chr10:102227702 G/C cg16342193 chr10:102329863 NA -0.37 -6.04 -0.32 4.06e-9 Palmitoleic acid (16:1n-7) levels; CRC cis rs2354432 0.607 rs58941651 chr1:146784919 T/C cg25205988 chr1:146714368 CHD1L -1.13 -9.43 -0.46 7.38e-19 Mitochondrial DNA levels; CRC cis rs11123170 0.640 rs1015754 chr2:113967990 T/C cg12889195 chr2:113992843 PAX8;LOC440839;LOC654433 -0.57 -7.73 -0.39 1.33e-13 Renal function-related traits (BUN); CRC cis rs425277 0.606 rs2503705 chr1:2076741 A/G cg04315214 chr1:2043799 PRKCZ -0.35 -6.06 -0.32 3.76e-9 Height; CRC trans rs916888 0.773 rs1378358 chr17:44787312 C/T cg23590916 chr17:43697445 MGC57346 0.73 7.26 0.37 2.84e-12 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs2243480 1.000 rs34193460 chr7:65393110 A/G cg12463550 chr7:65579703 CRCP 0.67 6.28 0.33 1.06e-9 Diabetic kidney disease; CRC cis rs2836974 0.563 rs997147 chr21:40695325 A/G cg17971929 chr21:40555470 PSMG1 -0.67 -9.98 -0.48 1.12e-20 Cognitive function; CRC cis rs2011503 1.000 rs58074958 chr19:19570555 G/C cg11584989 chr19:19387371 SF4 0.54 6.1 0.32 2.99e-9 Bipolar disorder; CRC cis rs3849570 0.961 rs3821548 chr3:81758728 C/G cg07356753 chr3:81810745 GBE1 -0.74 -11.08 -0.52 1.87e-24 Waist circumference;Body mass index; CRC cis rs8067545 0.641 rs850623 chr17:19837130 C/T cg04132472 chr17:19861366 AKAP10 0.43 6.83 0.35 4.01e-11 Schizophrenia; CRC cis rs1707322 1.000 rs785469 chr1:46521091 C/T cg06784218 chr1:46089804 CCDC17 -0.55 -9.71 -0.47 9.27e-20 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs7607369 0.609 rs13391398 chr2:219282429 A/G cg02176678 chr2:219576539 TTLL4 0.55 8.58 0.43 3.74e-16 Red blood cell count;Amyotrophic lateral sclerosis; CRC trans rs11088226 1.000 rs11701627 chr21:33927794 T/A cg09050820 chr6:167586206 TCP10L2 0.57 6.42 0.33 4.69e-10 Gastritis; CRC cis rs4268898 0.662 rs17733015 chr2:24509370 A/G cg06627628 chr2:24431161 ITSN2 -0.81 -11.43 -0.53 1.06e-25 Asthma; CRC cis rs1401999 1.000 rs6804242 chr3:183659463 A/T cg20387954 chr3:183756860 HTR3D 0.45 7.69 0.39 1.69e-13 Anterior chamber depth; CRC cis rs1153858 1.000 rs12437840 chr15:45669055 C/A cg10760299 chr15:45669010 GATM 0.5 7.73 0.39 1.29e-13 Homoarginine levels; CRC cis rs4728302 0.869 rs7792905 chr7:133595602 G/T cg03336402 chr7:133662267 EXOC4 -0.45 -6.51 -0.34 2.78e-10 Intelligence;Intelligence (multi-trait analysis); CRC cis rs4654899 0.758 rs6658679 chr1:21376451 T/C cg02927042 chr1:21476669 EIF4G3 -0.4 -6.25 -0.33 1.26e-9 Superior frontal gyrus grey matter volume; CRC cis rs28386778 0.897 rs894406 chr17:61901657 A/G cg06873352 chr17:61820015 STRADA 0.77 14.46 0.62 5e-37 Prudent dietary pattern; CRC cis rs7772486 0.776 rs4316025 chr6:146238032 C/T cg23711669 chr6:146136114 FBXO30 -0.64 -11.05 -0.52 2.43e-24 Lobe attachment (rater-scored or self-reported); CRC cis rs7552404 0.731 rs61770552 chr1:76373050 T/C cg10523679 chr1:76189770 ACADM 0.73 8.75 0.43 1.11e-16 Blood metabolite levels;Acylcarnitine levels; CRC trans rs34467563 1.000 rs35096529 chr8:97385140 T/A cg20465794 chr11:111169943 C11orf92;C11orf93 -0.43 -6.02 -0.31 4.67e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs11105298 0.838 rs4842488 chr12:89881564 C/G cg00757033 chr12:89920650 WDR51B 0.38 6.41 0.33 5.02e-10 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; CRC cis rs2857891 0.817 rs2638094 chr11:6981488 A/G cg12728517 chr11:6947552 ZNF215 0.56 5.9 0.31 9.21e-9 Response to cytadine analogues (cytosine arabinoside); CRC cis rs72945132 0.882 rs67822447 chr11:70230972 G/T cg14191688 chr11:70257035 CTTN 0.44 5.94 0.31 7.39e-9 Coronary artery disease; CRC cis rs10788264 0.569 rs3901289 chr10:124027433 T/C cg09507567 chr10:124027408 NA 0.36 7.82 0.4 7.32e-14 Total body bone mineral density; CRC cis rs870825 0.929 rs55635512 chr4:185589982 G/T cg07424746 chr4:185654737 MLF1IP -0.6 -5.84 -0.31 1.25e-8 Blood protein levels; CRC cis rs7927592 0.913 rs12272917 chr11:68263370 T/C cg16797656 chr11:68205561 LRP5 0.37 5.84 0.31 1.27e-8 Total body bone mineral density; CRC cis rs7312933 0.703 rs12371615 chr12:42563989 C/G cg11827402 chr12:42719852 PPHLN1;ZCRB1 0.62 8.65 0.43 2.38e-16 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CRC trans rs7395662 0.819 rs11039913 chr11:48692081 G/A cg21153622 chr11:89784906 NA -0.47 -7.44 -0.38 8.88e-13 HDL cholesterol; CRC cis rs2549003 1.000 rs2548997 chr5:131835395 C/T cg00255919 chr5:131827918 IRF1 -0.58 -11.35 -0.53 2.06e-25 Asthma (sex interaction); CRC cis rs4665809 0.887 rs2384324 chr2:26354239 A/G cg26119090 chr2:26468346 HADHA;HADHB -0.66 -8.16 -0.41 7.33e-15 Gut microbiome composition (summer); CRC cis rs863345 0.604 rs879637 chr1:158462697 C/T cg12129480 chr1:158549410 OR10X1 -0.3 -6.31 -0.33 8.84e-10 Pneumococcal bacteremia; CRC cis rs611744 0.647 rs1448150 chr8:109276161 T/C cg21045802 chr8:109455806 TTC35 0.43 6.83 0.35 4.07e-11 Dupuytren's disease; CRC cis rs728616 0.867 rs61860043 chr10:81946398 G/A cg05935833 chr10:81318306 SFTPA2 -0.75 -8.19 -0.41 5.8e-15 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs2303759 0.709 rs3760667 chr19:49814832 C/T cg22590775 chr19:49891494 CCDC155 0.59 7.7 0.39 1.6e-13 Multiple sclerosis; CRC trans rs6546324 0.625 rs2902025 chr2:67842424 A/G cg00907274 chr3:27498161 SLC4A7 -0.48 -6.13 -0.32 2.55e-9 Endometriosis; CRC cis rs3820068 0.705 rs4646083 chr1:15825564 G/A cg27534772 chr1:16042836 PLEKHM2 0.41 6.95 0.36 1.99e-11 Systolic blood pressure; CRC cis rs13315871 0.929 rs11706920 chr3:58279672 C/T cg20936604 chr3:58311152 NA -0.72 -6.79 -0.35 5.21e-11 Cholesterol, total; CRC cis rs9916302 0.707 rs11078903 chr17:37631924 G/A cg15445000 chr17:37608096 MED1 0.42 9.27 0.45 2.61e-18 Glomerular filtration rate (creatinine); CRC cis rs524281 0.773 rs2155198 chr11:66014300 C/T cg14036092 chr11:66035641 RAB1B -0.56 -6.35 -0.33 7.22e-10 Electroencephalogram traits; CRC trans rs79243044 0.786 rs16932549 chr11:5560909 C/T cg22917237 chr19:18633401 ELL -0.42 -6.11 -0.32 2.75e-9 QRS duration in Tripanosoma cruzi seropositivity; CRC cis rs861020 1.000 rs642961 chr1:209989270 A/G cg05527609 chr1:210001259 C1orf107 0.94 11.26 0.53 4.34e-25 Orofacial clefts; CRC cis rs10089 0.552 rs58595196 chr5:127558338 C/G cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.64 7.59 0.39 3.25e-13 Ileal carcinoids; CRC cis rs4713675 0.565 rs9394161 chr6:33669793 G/C cg14003231 chr6:33640908 ITPR3 0.49 7.87 0.4 5.32e-14 Plateletcrit; CRC cis rs72781680 0.528 rs56258075 chr2:24104256 C/G cg08917208 chr2:24149416 ATAD2B 0.88 8.73 0.43 1.32e-16 Lymphocyte counts; CRC cis rs2836974 0.965 rs8130984 chr21:40639966 A/C cg17971929 chr21:40555470 PSMG1 0.83 11.86 0.55 2.96e-27 Cognitive function; CRC cis rs13108904 0.967 rs4428235 chr4:1278891 C/T cg19318889 chr4:1322082 MAEA 0.4 5.65 0.3 3.41e-8 Obesity-related traits; CRC cis rs56114371 0.777 rs200483 chr6:27774824 C/T cg15845792 chr6:28175446 NA 0.71 6.06 0.32 3.71e-9 Breast cancer; CRC cis rs7727544 0.582 rs3749756 chr5:131534499 C/T cg18758796 chr5:131593413 PDLIM4 0.32 5.64 0.3 3.59e-8 Blood metabolite levels; CRC cis rs17767392 0.918 rs3784062 chr14:72090505 T/G cg13720639 chr14:72061746 SIPA1L1 0.55 6.66 0.34 1.13e-10 Mitral valve prolapse; CRC cis rs9649213 0.555 rs6948346 chr7:97959956 A/G cg21770322 chr7:97807741 LMTK2 0.49 7.92 0.4 3.71e-14 Prostate cancer (SNP x SNP interaction); CRC cis rs12476592 0.602 rs171902 chr2:63903236 C/T cg10828910 chr2:63850056 LOC388955 0.51 6.33 0.33 7.99e-10 Childhood ear infection; CRC cis rs9487051 0.807 rs1915835 chr6:109597483 C/T cg01475377 chr6:109611718 NA -0.47 -8.82 -0.44 6.68e-17 Reticulocyte fraction of red cells; CRC cis rs1552244 0.554 rs34391585 chr3:9999208 G/C cg16606324 chr3:10149918 C3orf24 0.45 6.8 0.35 4.87e-11 Alzheimer's disease; CRC cis rs10504229 0.906 rs67389108 chr8:58193718 G/A cg24829409 chr8:58192753 C8orf71 -0.61 -10.31 -0.49 9.11e-22 Developmental language disorder (linguistic errors); CRC cis rs7781266 0.739 rs11765450 chr7:133069682 A/G cg03336402 chr7:133662267 EXOC4 -0.52 -6.17 -0.32 1.99e-9 Educational attainment (college completion); CRC cis rs9926296 0.618 rs8058179 chr16:89846987 C/T cg04287289 chr16:89883240 FANCA -0.57 -9.01 -0.45 1.67e-17 Vitiligo; CRC cis rs7705042 0.865 rs12653866 chr5:141489921 C/T cg08523384 chr5:141488047 NDFIP1 -0.33 -5.79 -0.3 1.62e-8 Asthma; CRC cis rs10751667 0.666 rs10902242 chr11:949700 G/A cg01483505 chr11:975446 AP2A2 0.45 7.39 0.38 1.24e-12 Alzheimer's disease (late onset); CRC cis rs9486719 1.000 rs4343922 chr6:96876903 C/T cg06623918 chr6:96969491 KIAA0776 0.8 9.92 0.48 1.8899999999999998e-20 Migraine;Coronary artery disease; CRC cis rs367943 0.966 rs451425 chr5:112808637 A/G cg12552261 chr5:112820674 MCC -0.5 -7.78 -0.39 9.28e-14 Type 2 diabetes; CRC cis rs9443645 0.527 rs4706746 chr6:79674176 G/A cg09184832 chr6:79620586 NA -0.46 -7.89 -0.4 4.48e-14 Intelligence (multi-trait analysis); CRC cis rs35264875 0.851 rs72930611 chr11:68863659 G/T cg03469862 chr11:68924853 NA 0.46 6.03 0.32 4.33e-9 Blond vs. brown hair color; CRC cis rs8014671 0.553 rs8019852 chr14:70883943 G/A cg25576086 chr14:70833871 SYNJ2BP -0.36 -6.05 -0.32 3.87e-9 Prostate cancer; CRC cis rs1448094 0.621 rs10863089 chr12:86279699 C/T cg19622623 chr12:86230825 RASSF9 -0.39 -6.19 -0.32 1.77e-9 Major depressive disorder; CRC cis rs9914988 0.943 rs4262997 chr17:27129562 A/G cg16670446 chr17:27188758 MIR451;MIR144 0.55 8.52 0.43 5.75e-16 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs10189230 0.967 rs12993766 chr2:222350321 C/T cg14652038 chr2:222343519 EPHA4 0.52 10.03 0.48 7.88e-21 Urate levels in lean individuals; CRC trans rs1941687 0.505 rs1389534 chr18:31311161 C/G cg27147174 chr7:100797783 AP1S1 0.38 6.16 0.32 2.09e-9 Subjective well-being (multi-trait analysis);Subjective well-being; CRC cis rs7208859 0.614 rs73265646 chr17:29244023 C/T cg01831904 chr17:28903510 LRRC37B2 -0.57 -5.93 -0.31 7.57e-9 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs354033 1.000 rs354033 chr7:149289464 A/G cg24335155 chr7:149193227 ZNF746 -0.36 -6.07 -0.32 3.62e-9 Multiple sclerosis; CRC trans rs7395662 0.963 rs10769382 chr11:48590415 A/G cg21153622 chr11:89784906 NA -0.46 -7.35 -0.38 1.54e-12 HDL cholesterol; CRC cis rs2836974 0.897 rs13047678 chr21:40708853 C/T cg06238570 chr21:40685208 BRWD1 0.69 9.1 0.45 9.08e-18 Cognitive function; CRC cis rs7129220 0.512 rs12279871 chr11:10228196 G/A cg23875677 chr11:10229755 SBF2 -0.53 -5.97 -0.31 6.29e-9 Systolic blood pressure;Diastolic blood pressure;Blood pressure; CRC cis rs12549902 0.800 rs4736999 chr8:41506152 C/G cg17182837 chr8:41585554 ANK1 -0.36 -5.64 -0.3 3.73e-8 Corrected insulin response;Corrected insulin response adjusted for insulin sensitivity index;Insulin levels adjusted for BMI;Type 2 diabetes; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg26837270 chr19:42746884 GSK3A 0.38 6.02 0.31 4.53e-9 Liver disease severity in Alagille syndrome; CRC cis rs853679 0.760 rs9393910 chr6:28208192 C/G cg03623178 chr6:28175578 NA 0.74 7.82 0.4 7.43e-14 Depression; CRC cis rs10193935 0.901 rs7594010 chr2:42534896 C/T cg27598129 chr2:42591480 NA -0.68 -7.94 -0.4 3.19e-14 Colonoscopy-negative controls vs population controls; CRC cis rs7726839 0.540 rs61580655 chr5:597564 A/G cg09021430 chr5:549028 NA -0.7 -8.17 -0.41 6.68e-15 Obesity-related traits; CRC cis rs9467773 0.620 rs1027204 chr6:26639613 T/C cg09904177 chr6:26538194 HMGN4 0.72 11.4 0.53 1.39e-25 Intelligence (multi-trait analysis); CRC cis rs9443645 0.869 rs10943585 chr6:79502409 G/C cg11833968 chr6:79620685 NA -0.35 -6.23 -0.32 1.41e-9 Intelligence (multi-trait analysis); CRC cis rs995000 0.931 rs1168085 chr1:63112320 C/G cg19896129 chr1:63156450 NA -0.4 -6.23 -0.32 1.4e-9 Triglyceride levels; CRC cis rs7618501 0.602 rs2240326 chr3:50128386 G/A cg24308560 chr3:49941425 MST1R 0.48 7.6 0.39 3.19e-13 Intelligence (multi-trait analysis); CRC trans rs2243480 1.000 rs56291018 chr7:65390339 G/A cg10756647 chr7:56101905 PSPH 0.7 7.47 0.38 7.51e-13 Diabetic kidney disease; CRC cis rs12760731 0.623 rs1342848 chr1:178296461 A/G cg00404053 chr1:178313656 RASAL2 0.71 9.05 0.45 1.31e-17 Obesity-related traits; CRC cis rs7829975 0.711 rs12682352 chr8:8646246 A/G cg14979609 chr8:8086686 FLJ10661 -0.34 -5.67 -0.3 3.06e-8 Mood instability; CRC trans rs1455244 0.700 rs7229302 chr18:11508904 G/T cg21479305 chr19:14640168 TECR;MIR639 0.39 5.97 0.31 6.12e-9 Schizophrenia; CRC cis rs7082209 1.000 rs12265306 chr10:44811617 C/G cg09554077 chr10:44749378 NA 0.43 5.73 0.3 2.32e-8 Resistance to Mycobacterium tuberculosis in HIV-positive individuals measured by a negative tuberculin skin test (continuous); CRC cis rs7762018 0.943 rs7772889 chr6:170142458 T/C cg24289452 chr6:170231220 NA -0.57 -6.39 -0.33 5.75e-10 Thiazide-induced adverse metabolic effects in hypertensive patients; CRC cis rs2997447 0.655 rs2275950 chr1:26385003 T/C cg00300879 chr1:26503847 CNKSR1 0.29 5.63 0.3 3.87e-8 QRS complex (12-leadsum); CRC cis rs362272 0.545 rs2236052 chr4:3318413 C/T cg02993699 chr4:3415135 RGS12 0.4 6.67 0.35 1.09e-10 Serum sulfate level; CRC cis rs9837602 1.000 rs9837602 chr3:99824685 G/A cg07805332 chr3:99536008 MIR548G;C3orf26 -0.46 -6.09 -0.32 3.18e-9 Breast cancer; CRC cis rs2243480 0.708 rs35825036 chr7:65986502 T/C cg25985355 chr7:65971099 NA -0.52 -5.98 -0.31 5.68e-9 Diabetic kidney disease; CRC cis rs13144136 0.687 rs11737643 chr4:10658199 T/A cg10242279 chr4:10666415 CLNK -0.39 -6.63 -0.34 1.39e-10 Resistance to antihypertensive treatment in hypertension; CRC cis rs10540 1.000 rs61876342 chr11:496193 T/G cg03352830 chr11:487213 PTDSS2 0.67 7.7 0.39 1.63e-13 Body mass index; CRC cis rs9858542 0.953 rs35169793 chr3:49423274 A/G cg00383909 chr3:49044727 WDR6 0.43 5.65 0.3 3.45e-8 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs3857067 1.000 rs1397026 chr4:95013729 A/G cg11021082 chr4:95130006 SMARCAD1 -0.4 -6.05 -0.32 3.9e-9 QT interval; CRC cis rs2976388 0.507 rs13259549 chr8:143838519 T/C cg24046110 chr8:143859143 LYNX1 0.61 10.78 0.51 2.12e-23 Urinary tract infection frequency; CRC cis rs2985684 1.000 rs17121651 chr14:50097172 T/C cg04989706 chr14:50066350 PPIL5 -0.48 -6.8 -0.35 5.04e-11 Carotid intima media thickness; CRC cis rs1451375 0.617 rs2876829 chr7:50566762 A/G cg14593290 chr7:50529359 DDC 0.63 8.51 0.42 6.21e-16 Malaria; CRC cis rs9611519 0.894 rs9623320 chr22:41478482 G/A cg03806693 chr22:41940476 POLR3H -0.6 -7.76 -0.39 1.06e-13 Neuroticism; CRC cis rs11971779 0.680 rs6954531 chr7:139054706 C/T cg23387468 chr7:139079360 LUC7L2 0.41 7.04 0.36 1.14e-11 Diisocyanate-induced asthma; CRC cis rs66887589 0.616 rs10032299 chr4:120206419 C/T cg09307838 chr4:120376055 NA 0.54 8.34 0.42 2.04e-15 Diastolic blood pressure; CRC cis rs1799949 1.000 rs8176297 chr17:41203325 T/A cg05368731 chr17:41323189 NBR1 0.68 10.3 0.49 9.6e-22 Menopause (age at onset); CRC cis rs546131 0.928 rs535719 chr11:34853382 A/G cg11058730 chr11:34937778 PDHX;APIP 0.48 7.08 0.36 8.86e-12 Lung disease severity in cystic fibrosis; CRC cis rs9399135 0.967 rs12527683 chr6:135324534 C/T cg24558204 chr6:135376177 HBS1L 0.52 8.1 0.41 1.06e-14 Red blood cell count; CRC cis rs34375054 0.624 rs12580033 chr12:125676083 A/T cg20959480 chr12:125599568 AACS 0.39 5.8 0.3 1.59e-8 Post bronchodilator FEV1/FVC ratio; CRC cis rs13118159 0.742 rs34947293 chr4:1335034 T/C cg19318889 chr4:1322082 MAEA 0.5 7.48 0.38 7e-13 Longevity; CRC cis rs1552172 0.922 rs1778523 chr1:145698023 C/G cg11743829 chr1:145714124 CD160 -0.4 -5.95 -0.31 6.93e-9 Breast cancer; CRC cis rs1801251 0.896 rs921054 chr2:233694673 G/A cg25237894 chr2:233734115 C2orf82 -0.42 -6.63 -0.34 1.38e-10 Coronary artery disease; CRC cis rs11628318 0.588 rs12185065 chr14:103074636 A/C cg12046867 chr14:103022105 NA 0.43 6.28 0.33 1.07e-9 Platelet count; CRC cis rs10197940 0.662 rs2432945 chr2:152278414 T/C cg06191203 chr2:152266755 RIF1 -0.59 -8.71 -0.43 1.53e-16 Lung cancer; CRC trans rs4927850 0.957 rs4927851 chr3:195751853 A/G cg16724585 chr3:197361211 NA -0.49 -7.19 -0.37 4.47e-12 Pancreatic cancer; CRC cis rs28386778 0.897 rs4968598 chr17:61835579 T/C cg25654072 chr17:61904446 PSMC5;FTSJ3 0.71 11.11 0.52 1.42e-24 Prudent dietary pattern; CRC trans rs12797204 0.793 rs4456272 chr11:83469530 C/T cg07421806 chr5:128301136 SLC27A6 -0.6 -6.01 -0.31 4.99e-9 Cerebrospinal fluid t-tau:AB1-42 ratio; CRC cis rs9300255 0.602 rs1106241 chr12:123627016 T/C cg00376283 chr12:123451042 ABCB9 0.6 8.14 0.41 8.12e-15 Neutrophil percentage of white cells; CRC cis rs1055129 0.537 rs1135640 chr17:73949540 C/G cg08125733 chr17:73851984 WBP2 -0.5 -6.69 -0.35 9.53e-11 White matter hyperintensity burden; CRC cis rs6582630 0.519 rs8189599 chr12:38280748 A/G cg13010199 chr12:38710504 ALG10B 0.45 5.87 0.31 1.05e-8 Drug-induced liver injury (flucloxacillin); CRC trans rs2303319 0.504 rs62189055 chr2:162625749 C/A cg27342122 chr8:133787442 PHF20L1 -0.71 -6.02 -0.31 4.6e-9 Cognitive function; CRC cis rs9393777 0.513 rs11967852 chr6:26612870 G/T cg12292205 chr6:26970375 C6orf41 -0.6 -6.73 -0.35 7.52e-11 Intelligence (multi-trait analysis); CRC cis rs2811415 0.597 rs6801215 chr3:127762336 C/T cg13719885 chr3:127795394 NA -0.37 -5.67 -0.3 3.19e-8 Lung function (FEV1/FVC); CRC cis rs9325144 0.556 rs34565156 chr12:39028239 G/A cg26384229 chr12:38710491 ALG10B -0.52 -7.39 -0.38 1.25e-12 Morning vs. evening chronotype; CRC trans rs1814175 0.645 rs11040703 chr11:50024961 C/T cg15704280 chr7:45808275 SEPT13 -0.92 -16.92 -0.68 1.2e-46 Height; CRC cis rs2932538 0.922 rs6658555 chr1:113098534 C/T cg22162597 chr1:113214053 CAPZA1 0.69 9.78 0.47 5.26e-20 Systolic blood pressure;Diastolic blood pressure;Hypertension;Blood pressure; CRC cis rs10991814 0.841 rs7029087 chr9:94061633 A/G cg14446406 chr9:93919335 NA 0.58 6.46 0.34 3.77e-10 Neutrophil percentage of granulocytes; CRC cis rs9311474 0.629 rs7636227 chr3:52566682 G/A cg05573699 chr3:52720067 GNL3;PBRM1 -0.41 -6.35 -0.33 7.14e-10 Electroencephalogram traits; CRC trans rs11088226 0.645 rs7281844 chr21:33932435 T/C cg09050820 chr6:167586206 TCP10L2 0.85 9.07 0.45 1.07e-17 Gastritis; CRC cis rs9322193 0.962 rs952165 chr6:150120036 T/C cg05861140 chr6:150128134 PCMT1 -0.43 -7.05 -0.36 1.03e-11 Lung cancer; CRC cis rs7252981 0.632 rs880090 chr19:19740729 C/G cg03709012 chr19:19516395 GATAD2A 0.46 5.79 0.3 1.68e-8 Perceived unattractiveness to mosquitoes; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg23117447 chr6:34394069 RPS10 0.47 6.64 0.34 1.3e-10 Response to antipsychotic treatment; CRC cis rs10540 1.000 rs61876342 chr11:496193 T/G cg19913688 chr11:428466 ANO9 -0.7 -7.21 -0.37 3.76e-12 Body mass index; CRC cis rs950169 0.580 rs11634322 chr15:85172209 C/T cg17507749 chr15:85114479 UBE2QP1 0.62 8.85 0.44 5.68e-17 Schizophrenia; CRC cis rs6582630 0.555 rs11182429 chr12:38526679 A/C cg13010199 chr12:38710504 ALG10B 0.48 6.52 0.34 2.61e-10 Drug-induced liver injury (flucloxacillin); CRC cis rs6681460 1.000 rs6689864 chr1:67068112 T/C cg02459107 chr1:67143332 SGIP1 0.45 7.63 0.39 2.51e-13 Presence of antiphospholipid antibodies; CRC cis rs6120849 0.707 rs6120798 chr20:33610822 T/G cg08999081 chr20:33150536 PIGU 0.45 5.84 0.31 1.24e-8 Protein C levels; CRC cis rs3733346 0.520 rs62297086 chr4:909040 G/A cg20456258 chr4:962124 DGKQ 0.29 5.91 0.31 8.51e-9 Sjögren's syndrome; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg25533943 chr17:43325323 LOC100133991 0.35 5.98 0.31 5.84e-9 Liver disease severity in Alagille syndrome; CRC trans rs1005277 0.563 rs2505216 chr10:38482830 T/C cg23533926 chr12:111358616 MYL2 -0.54 -8.21 -0.41 5e-15 Extrinsic epigenetic age acceleration; CRC cis rs10992471 0.603 rs968040 chr9:95279985 C/A cg14631576 chr9:95140430 CENPP -0.39 -6.76 -0.35 6.18e-11 Visceral adipose tissue/subcutaneous adipose tissue ratio; CRC cis rs11098499 0.754 rs28643450 chr4:120245242 G/A cg24375607 chr4:120327624 NA 0.47 7.5 0.38 6.07e-13 Corneal astigmatism; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg21584983 chr19:11640070 ECSIT 0.51 7.29 0.37 2.33e-12 Response to antipsychotic treatment; CRC cis rs1003719 0.788 rs9977314 chr21:38471963 G/T cg10648535 chr21:38446584 PIGP;TTC3 0.52 7.42 0.38 1.03e-12 Eye color traits; CRC cis rs7552404 0.731 rs1493367 chr1:76344011 C/A cg03433033 chr1:76189801 ACADM -0.68 -8.4 -0.42 1.35e-15 Blood metabolite levels;Acylcarnitine levels; CRC cis rs7224685 0.569 rs8082483 chr17:4000849 G/A cg09695851 chr17:3907499 NA 0.5 6.36 0.33 6.84e-10 Type 2 diabetes; CRC cis rs1957429 0.901 rs2884308 chr14:65350406 A/T cg23373153 chr14:65346875 NA -0.71 -7.64 -0.39 2.4e-13 Pediatric areal bone mineral density (radius); CRC cis rs780096 0.526 rs13391837 chr2:27649375 A/G cg24768116 chr2:27665128 KRTCAP3 -0.35 -7.77 -0.39 1.01e-13 Total body bone mineral density; CRC cis rs9916302 0.904 rs6503506 chr17:37524653 C/A cg03013999 chr17:37608204 MED1 -0.47 -7.31 -0.37 2.1e-12 Glomerular filtration rate (creatinine); CRC cis rs4713118 0.868 rs10484401 chr6:27746590 A/T cg15845792 chr6:28175446 NA -0.69 -7.67 -0.39 1.94e-13 Parkinson's disease; CRC cis rs11122272 0.735 rs2491410 chr1:231532287 C/T cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.6 -9.04 -0.45 1.38e-17 Hemoglobin concentration; CRC cis rs6088580 0.524 rs6088570 chr20:33268295 T/C cg08999081 chr20:33150536 PIGU -0.37 -5.74 -0.3 2.14e-8 Glomerular filtration rate (creatinine); CRC cis rs970548 0.954 rs12249012 chr10:45992470 G/A cg15590007 chr10:45870220 ALOX5 0.48 6.1 0.32 2.9e-9 Total cholesterol levels;Cholesterol, total;HDL cholesterol;HDL cholesterol levels; CRC cis rs7937682 0.632 rs11214037 chr11:111773296 C/T cg09085632 chr11:111637200 PPP2R1B 0.94 14.87 0.63 1.28e-38 Primary sclerosing cholangitis; CRC cis rs6430538 0.646 rs6734820 chr2:135536808 A/G cg19078520 chr2:135676222 CCNT2 0.37 5.82 0.31 1.4e-8 Parkinson's disease; CRC cis rs9389248 0.690 rs2294321 chr6:135253048 T/G cg24558204 chr6:135376177 HBS1L -0.54 -7.86 -0.4 5.72e-14 High light scatter reticulocyte percentage of red cells; CRC trans rs6703335 0.870 rs10803142 chr1:243598234 A/G cg18553292 chr19:3762619 MRPL54;APBA3 0.47 6.58 0.34 1.91e-10 Schizophrenia;Schizophrenia, schizoaffective disorder or bipolar disorder; CRC cis rs4820539 1.000 rs5759598 chr22:23480962 T/G cg14186256 chr22:23484241 RTDR1 0.87 16.42 0.67 1.12e-44 Bone mineral density; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg14126493 chr5:176831297 F12 0.39 6.27 0.33 1.11e-9 Liver disease severity in Alagille syndrome; CRC cis rs7208859 0.623 rs34756112 chr17:29113016 A/G cg01831904 chr17:28903510 LRRC37B2 -0.62 -6.41 -0.33 5.13e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs12249377 0.519 rs11597471 chr10:92598767 C/G cg14313238 chr10:92632228 RPP30 0.45 6.35 0.33 7e-10 White matter microstructure (global fractional anisotropy); CRC cis rs1005277 0.579 rs2474571 chr10:38384639 T/G cg25427524 chr10:38739819 LOC399744 -0.77 -13.63 -0.6 7.43e-34 Extrinsic epigenetic age acceleration; CRC cis rs7224737 1.000 rs731152 chr17:40279680 G/A cg20291162 chr17:40259547 DHX58 -0.55 -7.98 -0.4 2.46e-14 Fibrinogen levels; CRC cis rs9527 0.590 rs7087459 chr10:104790999 T/C cg04362960 chr10:104952993 NT5C2 0.59 8.36 0.42 1.81e-15 Arsenic metabolism; CRC cis rs10256972 0.504 rs2949178 chr7:1209925 T/C cg27094323 chr7:1216898 NA -0.45 -7.58 -0.39 3.62e-13 Longevity;Endometriosis; CRC cis rs344364 0.529 rs186941 chr16:1930088 T/C cg00046913 chr16:1877150 HAGH;FAHD1 0.56 5.97 0.31 6.31e-9 Glomerular filtration rate in chronic kidney disease; CRC cis rs28386778 0.897 rs7207005 chr17:61860355 A/G cg25654072 chr17:61904446 PSMC5;FTSJ3 0.74 11.57 0.54 3.39e-26 Prudent dietary pattern; CRC cis rs6662572 0.686 rs72677541 chr1:46561560 C/T cg03123370 chr1:45965343 CCDC163P;MMACHC 0.48 6.26 0.33 1.22e-9 Blood protein levels; CRC cis rs947211 0.898 rs10900524 chr1:205748309 G/A cg14893161 chr1:205819251 PM20D1 0.41 5.67 0.3 3.2e-8 Parkinson's disease; CRC cis rs73206853 0.841 rs28772589 chr12:110845040 C/T cg12870014 chr12:110450643 ANKRD13A 0.78 8.56 0.43 4.41e-16 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC cis rs2245008 0.762 rs168800 chr16:83980391 T/C cg27171569 chr16:83987465 OSGIN1 0.59 9.67 0.47 1.2e-19 Pursuit maintenance gain; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg07762054 chr11:75273187 SERPINH1 0.47 6.05 0.32 3.99e-9 Anxiety disorder; CRC cis rs7258465 1.000 rs10403249 chr19:18604942 T/C cg06953865 chr19:18549723 ISYNA1 -0.37 -5.65 -0.3 3.56e-8 Breast cancer; CRC cis rs11785400 0.731 rs4294163 chr8:143730830 G/T cg24634471 chr8:143751801 JRK 0.52 7.15 0.37 5.69e-12 Schizophrenia; CRC cis rs72945132 0.882 rs57810426 chr11:70230030 G/A cg14191688 chr11:70257035 CTTN 0.43 5.92 0.31 8.02e-9 Coronary artery disease; CRC cis rs2243480 1.000 rs1267820 chr7:66050295 C/G cg18252515 chr7:66147081 NA -1.28 -15.03 -0.64 3.08e-39 Diabetic kidney disease; CRC cis rs9443645 0.901 rs9448590 chr6:79606429 C/G cg05283184 chr6:79620031 NA -0.58 -9.34 -0.46 1.48e-18 Intelligence (multi-trait analysis); CRC cis rs798554 0.757 rs2533879 chr7:2859847 G/A cg04166393 chr7:2884313 GNA12 0.51 6.73 0.35 7.55e-11 Height; CRC cis rs1044826 0.692 rs184155 chr3:139229772 G/A cg00490450 chr3:139108681 COPB2 -0.43 -6.45 -0.33 4.1e-10 Obesity-related traits; CRC cis rs2346160 0.899 rs206972 chr6:167689552 C/T cg04673565 chr6:167680447 NA -0.34 -5.96 -0.31 6.42e-9 Parental extreme longevity (95 years and older); CRC trans rs7613875 0.600 rs2856238 chr3:50158191 C/T cg21659725 chr3:3221576 CRBN 0.45 6.68 0.35 1.02e-10 Body mass index; CRC cis rs798554 0.610 rs2527696 chr7:2858315 T/C cg04166393 chr7:2884313 GNA12 0.37 5.65 0.3 3.43e-8 Height; CRC cis rs7249142 0.562 rs12980955 chr19:19283646 T/C cg12558012 chr19:19281197 LOC729991-MEF2B;MEF2B 0.54 8.44 0.42 1.05e-15 IgG glycosylation; CRC cis rs1448094 0.511 rs7959372 chr12:86160680 T/C cg19622623 chr12:86230825 RASSF9 -0.38 -5.78 -0.3 1.71e-8 Major depressive disorder; CRC cis rs6460942 0.908 rs6948654 chr7:12418546 T/A cg06484146 chr7:12443880 VWDE -0.71 -8.04 -0.41 1.64e-14 Coronary artery disease; CRC trans rs7647973 0.626 rs62260723 chr3:49872124 T/C cg21665057 chr3:196295764 WDR53;FBXO45 0.64 7.08 0.36 8.65e-12 Menarche (age at onset); CRC cis rs9894429 1.000 rs11651264 chr17:79576394 A/G cg13777783 chr17:79615861 NA 0.3 5.72 0.3 2.44e-8 Eye color traits; CRC cis rs1005277 0.540 rs2224248 chr10:38451886 A/G cg00409905 chr10:38381863 ZNF37A -0.67 -11.16 -0.52 9.81e-25 Extrinsic epigenetic age acceleration; CRC cis rs7618501 0.635 rs7635002 chr3:49989155 T/G cg24110177 chr3:50126178 RBM5 -0.45 -6.57 -0.34 2.01e-10 Intelligence (multi-trait analysis); CRC cis rs7258465 1.000 rs10427083 chr19:18550276 C/A cg01065977 chr19:18549689 ISYNA1 -0.41 -6.23 -0.33 1.39e-9 Breast cancer; CRC cis rs1552244 1.000 rs35220123 chr3:10083169 C/T cg13047869 chr3:10149882 C3orf24 0.57 7.76 0.39 1.1e-13 Alzheimer's disease; CRC cis rs75920871 0.528 rs12279066 chr11:116913909 C/G cg01368799 chr11:117014884 PAFAH1B2 -0.4 -5.67 -0.3 3.13e-8 Subjective well-being; CRC cis rs7267979 0.816 rs405822 chr20:25501314 A/G cg24626310 chr20:25276739 ABHD12;PYGB 0.33 5.75 0.3 2.01e-8 Liver enzyme levels (alkaline phosphatase); CRC cis rs4588572 0.537 rs7702000 chr5:77730556 A/G cg11446398 chr5:77624930 NA 0.42 5.92 0.31 8.18e-9 Triglycerides; CRC cis rs9916302 0.851 rs11657899 chr17:37626963 G/A cg03013999 chr17:37608204 MED1 0.45 6.87 0.35 3.15e-11 Glomerular filtration rate (creatinine); CRC cis rs728616 0.764 rs11201025 chr10:81742158 T/G cg05935833 chr10:81318306 SFTPA2 -0.48 -5.74 -0.3 2.18e-8 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs4728302 1.000 rs4728302 chr7:133630463 C/T cg03336402 chr7:133662267 EXOC4 0.46 6.91 0.36 2.44e-11 Intelligence;Intelligence (multi-trait analysis); CRC cis rs1816752 0.870 rs7981480 chr13:25015104 A/G cg02811702 chr13:24901961 NA 0.48 6.63 0.34 1.4e-10 Obesity-related traits; CRC cis rs3736485 0.868 rs2124592 chr15:51922979 G/A cg08986416 chr15:51914746 DMXL2 -0.48 -6.82 -0.35 4.42e-11 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs13108904 0.870 rs4974541 chr4:1244037 A/G cg02018176 chr4:1364513 KIAA1530 0.38 6.57 0.34 1.95e-10 Obesity-related traits; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg06946942 chr8:94929024 PDP1 0.42 6.09 0.32 3.18e-9 Intelligence (multi-trait analysis); CRC cis rs7595037 0.663 rs7422301 chr2:68655623 A/G cg12452813 chr2:68675892 NA -0.41 -6.01 -0.31 5.01e-9 Multiple sclerosis; CRC cis rs7259376 0.869 rs11673228 chr19:22596084 G/A cg02657401 chr19:22469223 NA 0.3 6.65 0.34 1.2e-10 Menopause (age at onset); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg04603834 chr13:50571387 TRIM13;DLEU2 0.44 6.33 0.33 7.82e-10 Intelligence (multi-trait analysis); CRC cis rs3768617 0.565 rs10752897 chr1:183071024 C/T ch.1.3577855R chr1:183094577 LAMC1 0.84 14.4 0.62 8.82e-37 Fuchs's corneal dystrophy; CRC cis rs2032447 0.714 rs199739 chr6:25960509 A/C cg03517284 chr6:25882590 NA -0.61 -8.62 -0.43 2.88e-16 Intelligence (multi-trait analysis); CRC cis rs7552404 1.000 rs7524467 chr1:76194054 C/G cg03433033 chr1:76189801 ACADM 0.81 11.12 0.52 1.29e-24 Blood metabolite levels;Acylcarnitine levels; CRC cis rs1707322 1.000 rs34446427 chr1:46417655 A/C cg06784218 chr1:46089804 CCDC17 0.51 9.06 0.45 1.19e-17 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs10504229 1.000 rs66477954 chr8:58187810 C/T cg24829409 chr8:58192753 C8orf71 -0.68 -11.34 -0.53 2.27e-25 Developmental language disorder (linguistic errors); CRC cis rs1448094 0.533 rs7307617 chr12:86151317 T/C cg18827107 chr12:86230957 RASSF9 0.37 5.73 0.3 2.21e-8 Major depressive disorder; CRC cis rs10504229 1.000 rs58947041 chr8:58188934 G/A cg02290350 chr8:58132656 NA -0.41 -5.85 -0.31 1.21e-8 Developmental language disorder (linguistic errors); CRC cis rs727505 1.000 rs10464529 chr7:124520308 G/A cg23710748 chr7:124431027 NA -0.8 -14.18 -0.62 6.24e-36 Lewy body disease; CRC cis rs7937682 0.961 rs552387 chr11:111490047 T/G cg19812747 chr11:111475976 SIK2 -0.57 -9.79 -0.47 5.04e-20 Primary sclerosing cholangitis; CRC cis rs6076065 0.723 rs6083095 chr20:23354090 C/T cg11657817 chr20:23433608 CST11 0.43 6.31 0.33 8.78e-10 Facial morphology (factor 15, philtrum width); CRC cis rs9309473 1.000 rs56154726 chr2:73721767 C/T cg20560298 chr2:73613845 ALMS1 -0.47 -5.76 -0.3 1.89e-8 Metabolite levels; CRC cis rs7274811 0.625 rs293723 chr20:31927706 A/G cg21523528 chr20:32077966 CBFA2T2 0.42 6.01 0.31 4.91e-9 Height; CRC trans rs9650657 0.683 rs7836366 chr8:10585683 A/G cg06636001 chr8:8085503 FLJ10661 -0.49 -6.95 -0.36 1.99e-11 Neuroticism; CRC cis rs1799949 0.965 rs9911630 chr17:41188342 A/G cg23758822 chr17:41437982 NA 0.83 15.15 0.64 1.06e-39 Menopause (age at onset); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg06224551 chr11:124670268 C11orf61 0.4 6.34 0.33 7.63e-10 Liver disease severity in Alagille syndrome; CRC cis rs642803 0.933 rs644740 chr11:65561468 C/T cg27068330 chr11:65405492 SIPA1 0.41 5.72 0.3 2.38e-8 Urate levels; CRC cis rs17270561 0.609 rs6924794 chr6:25735874 A/G cg17691542 chr6:26056736 HIST1H1C 0.73 9.26 0.45 2.71e-18 Iron status biomarkers; CRC cis rs185694 1.000 rs653251 chr13:30894542 C/T cg07600127 chr13:30881527 KATNAL1 -0.54 -5.84 -0.31 1.28e-8 Antineutrophil cytoplasmic antibody-associated vasculitis; CRC cis rs77216612 0.835 rs56692845 chr12:12887811 C/T cg04607235 chr12:12878440 APOLD1 -0.97 -13.65 -0.6 6.09e-34 Lymphocyte counts; CRC trans rs12599106 0.792 rs11648801 chr16:34360980 C/T cg21548813 chr6:291882 DUSP22 -0.53 -7.34 -0.38 1.68e-12 Menopause (age at onset); CRC cis rs9463078 0.506 rs4714820 chr6:44736737 T/A cg25276700 chr6:44698697 NA 0.31 7.79 0.39 8.81e-14 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; CRC cis rs597539 0.617 rs669659 chr11:68635623 G/C cg06112835 chr11:68658793 MRPL21 0.42 6.86 0.35 3.41e-11 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs4713118 0.955 rs9468203 chr6:27688667 A/G cg20933634 chr6:27740509 NA 0.58 8.19 0.41 5.65e-15 Parkinson's disease; CRC cis rs6089584 0.854 rs6061407 chr20:60622048 A/C cg06108461 chr20:60628389 TAF4 -0.92 -16.07 -0.66 2.77e-43 Body mass index; CRC cis rs11971779 0.680 rs11772026 chr7:139052589 T/G cg07862535 chr7:139043722 LUC7L2 0.57 7.35 0.38 1.61e-12 Diisocyanate-induced asthma; CRC cis rs1707322 0.963 rs6429581 chr1:46319096 G/A cg06784218 chr1:46089804 CCDC17 0.6 10.78 0.51 2.04e-23 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs12497850 0.865 rs7649458 chr3:48920127 C/T cg20833759 chr3:49053208 WDR6;DALRD3 0.51 8.74 0.43 1.19e-16 Parkinson's disease; CRC cis rs6681460 0.932 rs665319 chr1:67175488 A/G cg02459107 chr1:67143332 SGIP1 0.35 5.95 0.31 6.91e-9 Presence of antiphospholipid antibodies; CRC cis rs9457247 0.508 rs6902119 chr6:167505791 T/C cg07513332 chr6:167530253 CCR6 0.35 6.33 0.33 7.98e-10 Crohn's disease; CRC cis rs10493773 0.609 rs12097932 chr1:86182216 A/G cg23216685 chr1:86174607 ZNHIT6 -0.28 -6.69 -0.35 9.64e-11 Urate levels in overweight individuals; CRC cis rs9858542 0.953 rs6766131 chr3:49538932 T/C cg03060546 chr3:49711283 APEH -0.47 -6.6 -0.34 1.63e-10 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs7552404 0.656 rs11161792 chr1:76336746 C/T cg22875332 chr1:76189707 ACADM 0.6 7.54 0.38 4.49e-13 Blood metabolite levels;Acylcarnitine levels; CRC cis rs7811142 0.830 rs11768967 chr7:99967644 G/A cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.14 17.06 0.69 3.53e-47 Platelet count; CRC cis rs1059312 0.808 rs11059921 chr12:129289919 C/T cg21616243 chr12:129299702 MGC16384;SLC15A4 -0.75 -13.35 -0.59 8.82e-33 Systemic lupus erythematosus; CRC cis rs7811142 0.830 rs41280971 chr7:99954457 G/T cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.11 15.98 0.66 5.9e-43 Platelet count; CRC cis rs78456975 1.000 rs13397299 chr2:1564222 A/C cg12573674 chr2:1569213 NA -0.77 -8.18 -0.41 6.35e-15 Placebo response in major depressive disorder (% change in symptom score); CRC cis rs738322 1.000 rs4382 chr22:38570842 T/C cg25457927 chr22:38595422 NA -0.35 -7.4 -0.38 1.13e-12 Cutaneous nevi; CRC cis rs1949733 0.958 rs3103069 chr4:8509451 T/G cg11789530 chr4:8429930 ACOX3 -0.86 -12.67 -0.57 3.22e-30 Response to antineoplastic agents; CRC cis rs7666738 0.962 rs13147921 chr4:99069296 C/G cg17366294 chr4:99064904 C4orf37 0.46 7.14 0.37 5.84e-12 Colonoscopy-negative controls vs population controls; CRC cis rs11148252 0.846 rs1056335 chr13:52989863 C/T cg12458913 chr13:53173898 NA 0.52 8.02 0.4 1.88e-14 Lewy body disease; CRC trans rs7615952 0.932 rs13314869 chr3:125644669 G/A cg00769240 chr8:12517080 NA -0.57 -7.0 -0.36 1.47e-11 Blood pressure (smoking interaction); CRC cis rs11098499 0.954 rs17046116 chr4:120387259 G/A cg09307838 chr4:120376055 NA 0.71 10.92 0.52 6.75e-24 Corneal astigmatism; CRC cis rs10986311 0.832 rs867610 chr9:127086129 T/C cg14243010 chr9:127117328 LOC100129034;PSMB7 -0.41 -5.99 -0.31 5.54e-9 Vitiligo; CRC cis rs758324 0.947 rs6596039 chr5:131198652 C/A cg06307176 chr5:131281290 NA 0.43 6.3 0.33 9.35e-10 Alzheimer's disease in APOE e4- carriers; CRC cis rs4713118 0.586 rs6905522 chr6:28086479 A/C cg06470822 chr6:28175283 NA 1.0 13.06 0.58 1.06e-31 Parkinson's disease; CRC cis rs17152411 0.895 rs7079416 chr10:126587312 C/G cg07906193 chr10:126599966 NA 0.57 6.45 0.33 4.11e-10 Height; CRC trans rs7615952 0.599 rs2333408 chr3:125732098 G/A cg07211511 chr3:129823064 LOC729375 -0.81 -12.53 -0.57 1e-29 Blood pressure (smoking interaction); CRC cis rs6502050 0.835 rs7503189 chr17:80099486 C/A cg11859384 chr17:80120422 CCDC57 -0.37 -5.85 -0.31 1.16e-8 Life satisfaction; CRC cis rs10504229 1.000 rs61998259 chr8:58192290 T/C cg01721255 chr8:58191610 C8orf71 0.49 6.17 0.32 2e-9 Developmental language disorder (linguistic errors); CRC cis rs4927850 1.000 rs7614767 chr3:195753451 C/T cg00031303 chr3:195681400 NA 0.51 7.23 0.37 3.43e-12 Pancreatic cancer; CRC cis rs7224685 0.520 rs12453690 chr17:4037678 T/C cg10724054 chr17:3904396 NA 0.45 7.1 0.36 7.76e-12 Type 2 diabetes; CRC cis rs10512697 0.655 rs34428582 chr5:3503596 A/G cg19473799 chr5:3511975 NA -0.82 -6.32 -0.33 8.41e-10 Immune response to smallpox vaccine (IL-6); CRC cis rs651907 0.557 rs11710533 chr3:101351472 G/A cg12386194 chr3:101231763 SENP7 0.49 6.98 0.36 1.6e-11 Colorectal cancer; CRC cis rs11864453 0.713 rs9925763 chr16:72142595 C/A cg23815491 chr16:72088622 HP 0.49 7.46 0.38 7.97e-13 Fibrinogen levels; CRC trans rs561341 1.000 rs535151 chr17:30317405 C/T cg27661571 chr11:113659931 NA -0.61 -8.01 -0.4 2.05e-14 Hip circumference adjusted for BMI; CRC trans rs11581859 0.950 rs7521703 chr1:99359039 A/G cg12183875 chr3:169587454 LRRC31 0.25 5.99 0.31 5.39e-9 Response to cognitive-behavioural therapy in anxiety disorder; CRC cis rs2836974 0.533 rs4817999 chr21:40554355 C/A cg17971929 chr21:40555470 PSMG1 -0.73 -11.33 -0.53 2.41e-25 Cognitive function; CRC cis rs6570726 0.791 rs9373463 chr6:145894762 C/T cg13319975 chr6:146136371 FBXO30 -0.42 -6.22 -0.32 1.53e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs11105298 0.685 rs117578503 chr12:89836672 G/C cg00757033 chr12:89920650 WDR51B 0.36 6.1 0.32 2.97e-9 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; CRC cis rs10242455 0.717 rs58649180 chr7:99336045 C/T cg18809830 chr7:99032528 PTCD1 -0.8 -5.98 -0.31 5.96e-9 Blood metabolite levels; CRC cis rs2243480 0.901 rs778687 chr7:65835819 G/A cg18252515 chr7:66147081 NA -1.3 -15.32 -0.65 2.37e-40 Diabetic kidney disease; CRC cis rs3785574 0.962 rs8079161 chr17:61808561 C/G cg06601766 chr17:61851465 DDX42;CCDC47 0.58 8.28 0.42 3.2e-15 Height; CRC cis rs10504229 0.815 rs55855654 chr8:58164299 T/G cg05313129 chr8:58192883 C8orf71 -0.5 -6.34 -0.33 7.58e-10 Developmental language disorder (linguistic errors); CRC cis rs1559088 0.948 rs7259333 chr19:33579128 T/C cg27124370 chr19:33622961 WDR88 0.45 6.19 0.32 1.74e-9 Bone ultrasound measurement (broadband ultrasound attenuation); CRC cis rs28386778 0.863 rs2665834 chr17:61904724 T/C cg06601766 chr17:61851465 DDX42;CCDC47 0.44 5.95 0.31 6.97e-9 Prudent dietary pattern; CRC cis rs6598955 0.627 rs12143920 chr1:26575834 A/G cg04990556 chr1:26633338 UBXN11 0.56 6.02 0.32 4.53e-9 Obesity-related traits; CRC cis rs6951245 0.554 rs2070118 chr7:1132505 G/A cg22907277 chr7:1156413 C7orf50 0.87 11.26 0.53 4.14e-25 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs4713118 0.869 rs9283882 chr6:27715258 A/C cg15845792 chr6:28175446 NA 0.66 9.22 0.45 3.55e-18 Parkinson's disease; CRC cis rs1707322 0.686 rs3014251 chr1:46077428 G/C cg06784218 chr1:46089804 CCDC17 -0.65 -11.87 -0.55 2.63e-27 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg19410789 chr1:226249811 LOC440926;H3F3A 0.43 6.0 0.31 5.14e-9 Response to antipsychotic treatment; CRC cis rs9296404 1 rs9296404 chr6:42925803 T/C cg00597713 chr6:42947103 PEX6 -0.4 -5.69 -0.3 2.88e-8 Plasma homocysteine levels (post-methionine load test); CRC cis rs6502050 0.835 rs4499294 chr17:80148346 C/T cg22110888 chr17:80059540 CCDC57 0.4 6.24 0.33 1.33e-9 Life satisfaction; CRC cis rs1223397 0.524 rs2496151 chr6:13314541 A/G cg07912922 chr6:13274314 PHACTR1 0.36 5.69 0.3 2.83e-8 Blood pressure; CRC cis rs4727027 0.727 rs1568944 chr7:148873497 A/T cg12479418 chr7:148823350 ZNF425;ZNF398 0.49 6.68 0.35 1.03e-10 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC cis rs2361718 0.603 rs12951255 chr17:78085597 A/G cg20811857 chr17:78079795 GAA -0.46 -7.66 -0.39 2.1e-13 Yeast infection; CRC cis rs7208859 0.673 rs11651802 chr17:29159660 T/C cg13385521 chr17:29058706 SUZ12P 0.7 8.1 0.41 1.05e-14 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs4547160 0.606 rs10784329 chr12:63477676 C/T cg26727693 chr12:63544175 AVPR1A -0.43 -7.83 -0.4 6.9e-14 Morning vs. evening chronotype; CRC cis rs7312933 0.584 rs6582395 chr12:42700141 T/C cg11827402 chr12:42719852 PPHLN1;ZCRB1 0.64 8.98 0.44 2.08e-17 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CRC cis rs10883723 0.810 rs1884929 chr10:104275418 C/T cg11453585 chr10:104263688 ACTR1A;SUFU 0.91 17.43 0.69 1.17e-48 Allergic disease (asthma, hay fever or eczema); CRC cis rs7666738 0.830 rs4699598 chr4:99019158 C/T cg17366294 chr4:99064904 C4orf37 0.43 7.29 0.37 2.28e-12 Colonoscopy-negative controls vs population controls; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg05143954 chr8:103424275 UBR5 0.44 6.92 0.36 2.4e-11 Liver disease severity in Alagille syndrome; CRC cis rs9649213 0.593 rs13246725 chr7:97914898 C/G cg24562669 chr7:97807699 LMTK2 0.45 7.54 0.38 4.56e-13 Prostate cancer (SNP x SNP interaction); CRC cis rs1465370 0.720 rs2402995 chr7:130016595 C/T cg03229158 chr7:130009420 NA 0.46 6.43 0.33 4.51e-10 Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction);Waist circumference adjusted for BMI in active individuals;Waist circumference adjusted for body mass index; CRC trans rs1814175 0.645 rs847639 chr11:49919603 C/T cg15704280 chr7:45808275 SEPT13 -0.95 -16.82 -0.68 3.11e-46 Height; CRC cis rs10979 0.557 rs9376768 chr6:143909492 C/T cg25407410 chr6:143891975 LOC285740 -0.67 -8.94 -0.44 2.93e-17 Hypospadias; CRC cis rs6121246 0.529 rs6060210 chr20:30187681 C/T cg18721089 chr20:30220636 NA -0.52 -7.93 -0.4 3.54e-14 Mean corpuscular hemoglobin; CRC trans rs11098499 1.000 rs3749591 chr4:120214030 T/G cg25214090 chr10:38739885 LOC399744 0.5 7.38 0.38 1.33e-12 Corneal astigmatism; CRC cis rs780096 0.546 rs6547626 chr2:27646770 C/T cg21248554 chr2:27665150 KRTCAP3 -0.32 -7.39 -0.38 1.22e-12 Total body bone mineral density; CRC cis rs9915657 0.933 rs17246133 chr17:70140485 A/G cg09344028 chr17:70110421 NA 0.44 6.73 0.35 7.77e-11 Thyroid hormone levels; CRC cis rs3204270 0.639 rs7215738 chr17:79659847 C/T cg18367735 chr17:79674897 NA 0.48 5.67 0.3 3.17e-8 Dental caries; CRC cis rs6951245 0.745 rs79788515 chr7:1101079 C/T cg26224354 chr7:1096374 C7orf50;GPR146 -0.92 -11.86 -0.55 2.94e-27 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs3924048 0.574 rs11121925 chr1:12613130 A/C cg23650765 chr1:12612165 NA 0.38 7.32 0.37 1.96e-12 Optic cup area; CRC cis rs6963495 0.818 rs73190189 chr7:105164452 G/A cg13798780 chr7:105162888 PUS7 0.68 8.08 0.41 1.27e-14 Bipolar disorder (body mass index interaction); CRC trans rs35110281 0.720 rs162375 chr21:44927015 C/T cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO -0.5 -8.24 -0.41 4.01e-15 Mean corpuscular volume; CRC cis rs3785574 0.962 rs4480868 chr17:61788859 C/T cg22520471 chr17:61851767 DDX42;CCDC47 0.43 6.03 0.32 4.39e-9 Height; CRC cis rs9611565 0.649 rs202625 chr22:41827082 G/A cg03806693 chr22:41940476 POLR3H 1.12 13.67 0.6 5.31e-34 Vitiligo; CRC cis rs2304069 0.954 rs6861548 chr5:149384680 A/G cg22760475 chr5:149380129 HMGXB3;TIGD6 0.86 10.04 0.48 7.38e-21 HIV-1 control; CRC trans rs2303319 0.504 rs35304298 chr2:162617185 G/T cg09481857 chr22:21368659 P2RX6;MGC16703 -0.64 -6.28 -0.33 1.08e-9 Cognitive function; CRC cis rs12137294 0.866 rs896318 chr1:205205784 A/G cg24159697 chr1:205181237 DSTYK -0.34 -6.25 -0.33 1.31e-9 Red cell distribution width; CRC cis rs2243480 1.000 rs6966322 chr7:65646754 A/G cg18252515 chr7:66147081 NA 1.23 14.37 0.62 1.07e-36 Diabetic kidney disease; CRC cis rs4713118 0.738 rs200465 chr6:27757654 T/A cg20933634 chr6:27740509 NA 0.64 9.08 0.45 1.03e-17 Parkinson's disease; CRC cis rs4692589 0.581 rs6821231 chr4:170959988 C/T cg19918862 chr4:170955249 NA 0.52 7.11 0.36 7.44e-12 Anxiety disorder; CRC cis rs7618501 0.573 rs7634917 chr3:50049299 T/G cg05623727 chr3:50126028 RBM5 -0.44 -7.37 -0.38 1.39e-12 Intelligence (multi-trait analysis); CRC cis rs208515 0.525 rs10455593 chr6:66691341 C/T cg07460842 chr6:66804631 NA 0.97 12.24 0.56 1.17e-28 Exhaled nitric oxide levels; CRC cis rs10504229 1.000 rs56344560 chr8:58180626 C/G cg24829409 chr8:58192753 C8orf71 -0.67 -11.02 -0.52 3.06e-24 Developmental language disorder (linguistic errors); CRC cis rs28386778 0.897 rs9913323 chr17:61851485 C/A cg06873352 chr17:61820015 STRADA 0.76 14.31 0.62 1.87e-36 Prudent dietary pattern; CRC cis rs853679 0.517 rs9393893 chr6:28109262 T/C cg06470822 chr6:28175283 NA 1.03 13.59 0.6 1.04e-33 Depression; CRC cis rs4481887 0.790 rs6587440 chr1:248415662 A/G cg00666640 chr1:248458726 OR2T12 0.49 8.68 0.43 1.83e-16 Common traits (Other); CRC cis rs7617773 0.817 rs34225441 chr3:48308891 T/A cg11946769 chr3:48343235 NME6 0.73 9.77 0.47 5.91e-20 Coronary artery disease; CRC cis rs17826219 0.500 rs57005940 chr17:29066329 C/G cg01831904 chr17:28903510 LRRC37B2 -0.62 -6.39 -0.33 5.8e-10 Body mass index; CRC cis rs2440129 0.632 rs2292353 chr17:6903537 C/T cg03762994 chr17:6899332 ALOX12 0.62 11.63 0.54 1.95e-26 Tonsillectomy; CRC cis rs2361710 1.000 rs2361710 chr17:78111877 C/T cg20811857 chr17:78079795 GAA 0.39 6.47 0.34 3.48e-10 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count;Immature fraction of reticulocytes; CRC cis rs4805272 0.512 rs66830923 chr19:29321277 C/T cg12756686 chr19:29218302 NA 0.47 6.23 0.33 1.4e-9 Plasma omega-3 polyunsaturated fatty acid levels (docosahexaenoic acid); CRC cis rs11711311 1.000 rs28394480 chr3:113485143 T/C cg15478005 chr3:113465772 ATP6V1A;NAA50 0.45 6.3 0.33 9.55e-10 IgG glycosylation; CRC cis rs2251381 0.722 rs2251278 chr21:30529234 A/G cg08807101 chr21:30365312 RNF160 0.66 9.67 0.47 1.29e-19 Selective IgA deficiency; CRC cis rs9611565 0.512 rs6002474 chr22:42168181 A/G cg03806693 chr22:41940476 POLR3H 1.11 13.62 0.6 8.15e-34 Vitiligo; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg20409358 chr4:174255887 HMGB2 0.47 6.75 0.35 6.85e-11 Response to antipsychotic treatment; CRC cis rs72945132 0.882 rs72945168 chr11:70131471 G/C cg14191688 chr11:70257035 CTTN 0.4 5.62 0.3 4.07e-8 Coronary artery disease; CRC cis rs6502050 0.835 rs4789737 chr17:80123269 G/A cg13198984 chr17:80129470 CCDC57 0.47 8.35 0.42 1.88e-15 Life satisfaction; CRC cis rs10499694 0.933 rs11575356 chr7:50594821 T/C cg18232548 chr7:50535776 DDC -0.4 -6.18 -0.32 1.92e-9 Body mass index; CRC cis rs10883723 0.810 rs12162 chr10:104240498 A/G cg04362960 chr10:104952993 NT5C2 -0.47 -5.91 -0.31 8.59e-9 Allergic disease (asthma, hay fever or eczema); CRC trans rs875971 0.660 rs2191268 chr7:66110224 C/T cg07498280 chr19:1250537 MIDN -0.39 -6.0 -0.31 5.34e-9 Aortic root size; CRC cis rs6951245 0.935 rs11766669 chr7:1063593 C/T cg03188948 chr7:1209495 NA 0.6 6.23 0.32 1.41e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg13717333 chr12:122459966 BCL7A 0.52 7.19 0.37 4.31e-12 Anxiety disorder; CRC cis rs13191362 0.507 rs1954806 chr6:163051858 G/C cg21926612 chr6:163149169 PACRG;PARK2 -0.62 -9.51 -0.46 4.07e-19 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs17376456 0.877 rs13165147 chr5:93422214 G/A cg25358565 chr5:93447407 FAM172A 1.02 10.5 0.5 1.98e-22 Diabetic retinopathy; CRC trans rs4332037 0.539 rs868754 chr7:2033780 G/C cg11693508 chr17:37793320 STARD3 0.65 7.17 0.37 5.14e-12 Bipolar disorder; CRC cis rs7264396 0.563 rs2425122 chr20:34328848 C/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.49 -6.63 -0.34 1.35e-10 Total cholesterol levels; CRC cis rs1059312 0.500 rs12303338 chr12:129276641 C/T cg21616243 chr12:129299702 MGC16384;SLC15A4 0.52 7.59 0.39 3.27e-13 Systemic lupus erythematosus; CRC cis rs12142240 0.698 rs55971480 chr1:46823206 G/T cg00530320 chr1:46809349 NSUN4 0.59 8.03 0.41 1.69e-14 Menopause (age at onset); CRC trans rs11098499 0.708 rs10005237 chr4:120237897 T/C cg25214090 chr10:38739885 LOC399744 0.53 8.45 0.42 9.68e-16 Corneal astigmatism; CRC cis rs2346160 0.899 rs172283 chr6:167691225 T/C cg27333441 chr6:167680455 NA -0.38 -6.16 -0.32 2.08e-9 Parental extreme longevity (95 years and older); CRC cis rs13144136 0.687 rs12511309 chr4:10657137 A/G cg10242279 chr4:10666415 CLNK -0.38 -6.5 -0.34 2.93e-10 Resistance to antihypertensive treatment in hypertension; CRC cis rs4713118 0.868 rs760587 chr6:27740300 C/A cg12273811 chr6:28175739 NA 0.51 5.71 0.3 2.55e-8 Parkinson's disease; CRC cis rs3733585 0.604 rs73215003 chr4:10126317 C/G cg00071950 chr4:10020882 SLC2A9 -0.54 -8.8 -0.44 7.71e-17 Cleft plate (environmental tobacco smoke interaction); CRC cis rs7666738 0.830 rs62318470 chr4:98925846 A/C cg05340658 chr4:99064831 C4orf37 0.6 9.35 0.46 1.34e-18 Colonoscopy-negative controls vs population controls; CRC cis rs4727027 0.901 rs6943937 chr7:148869915 A/G cg12479418 chr7:148823350 ZNF425;ZNF398 0.43 5.89 0.31 9.77e-9 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC cis rs10504229 0.679 rs111843870 chr8:58126798 A/G cg04204079 chr8:58130323 NA -0.45 -5.78 -0.3 1.71e-8 Developmental language disorder (linguistic errors); CRC cis rs9322193 0.923 rs9800614 chr6:149965740 G/A cg05861140 chr6:150128134 PCMT1 -0.38 -6.15 -0.32 2.31e-9 Lung cancer; CRC cis rs951366 0.764 rs823141 chr1:205741426 T/C cg23034840 chr1:205782522 SLC41A1 0.48 6.7 0.35 9.11e-11 Menarche (age at onset); CRC cis rs270601 0.955 rs273911 chr5:131661526 C/G cg20512303 chr5:131592959 PDLIM4 0.4 6.88 0.35 3.07e-11 Acylcarnitine levels; CRC cis rs6582630 0.555 rs11181684 chr12:38388000 T/C cg26384229 chr12:38710491 ALG10B 0.68 9.69 0.47 1.09e-19 Drug-induced liver injury (flucloxacillin); CRC cis rs8180040 0.966 rs59586735 chr3:47518325 C/T cg02527881 chr3:46936655 PTH1R 0.38 7.08 0.36 8.93e-12 Colorectal cancer; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg17022635 chr16:31190875 FUS 0.43 6.19 0.32 1.74e-9 Intelligence (multi-trait analysis); CRC cis rs7659604 0.539 rs7686200 chr4:122764553 C/T cg19748678 chr4:122722346 EXOSC9 0.63 9.96 0.48 1.37e-20 Type 2 diabetes; CRC cis rs1552244 1.000 rs34179822 chr3:10140017 A/G cg18598329 chr3:10140678 FANCD2;C3orf24 -0.9 -13.24 -0.59 2.25e-32 Alzheimer's disease; CRC cis rs7312933 0.898 rs10880221 chr12:42384589 C/A cg17420585 chr12:42539391 GXYLT1 -0.41 -6.07 -0.32 3.59e-9 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CRC cis rs10540 1.000 rs12419716 chr11:503385 C/G cg21784768 chr11:537496 LRRC56 -0.69 -6.56 -0.34 2.11e-10 Body mass index; CRC cis rs172166 0.637 rs1233691 chr6:28153897 T/G cg25164649 chr6:28176230 NA 0.68 10.13 0.49 3.57e-21 Cardiac Troponin-T levels; CRC cis rs72615157 0.561 rs113401658 chr7:99858505 C/T cg19337854 chr7:99768885 GPC2 0.47 5.91 0.31 8.46e-9 Lung function (FEV1/FVC); CRC cis rs7772486 0.754 rs702323 chr6:146008274 A/G cg05347473 chr6:146136440 FBXO30 -0.38 -5.7 -0.3 2.68e-8 Lobe attachment (rater-scored or self-reported); CRC cis rs1801251 1.000 rs67013068 chr2:233608253 G/C cg25237894 chr2:233734115 C2orf82 0.51 8.25 0.41 3.8e-15 Coronary artery disease; CRC cis rs7086627 0.515 rs10887894 chr10:82209952 A/G cg00277334 chr10:82204260 NA -0.84 -16.95 -0.68 9.58e-47 Post bronchodilator FEV1; CRC cis rs1448094 0.512 rs7957170 chr12:86243282 A/G cg18827107 chr12:86230957 RASSF9 -0.45 -7.42 -0.38 9.97e-13 Major depressive disorder; CRC cis rs116095464 0.558 rs7736600 chr5:231337 A/C cg22857025 chr5:266934 NA -1.21 -16.57 -0.67 2.78e-45 Breast cancer; CRC trans rs7647973 0.626 rs62262672 chr3:49655927 T/A cg21659725 chr3:3221576 CRBN 0.63 6.49 0.34 3.16e-10 Menarche (age at onset); CRC cis rs12541635 0.677 rs10086055 chr8:107024129 C/T cg10147462 chr8:107024639 NA 0.57 10.07 0.49 5.63e-21 Age of smoking initiation; CRC cis rs7917772 0.582 rs4919661 chr10:104358403 T/C cg11453585 chr10:104263688 ACTR1A;SUFU 0.82 15.29 0.64 3.12e-40 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC cis rs3026101 0.671 rs1071705 chr17:5290033 T/C cg25236894 chr17:5323110 RPAIN;NUP88 0.42 6.82 0.35 4.25e-11 Body mass index; CRC cis rs9427116 0.502 rs7531982 chr1:154596122 A/T cg17218026 chr1:154582156 ADAR 0.67 11.52 0.54 5.03e-26 Blood protein levels; CRC cis rs701145 0.556 rs355787 chr3:153994502 T/C cg16511985 chr3:153974050 SGEF 0.43 5.77 0.3 1.85e-8 Coronary artery disease; CRC cis rs13118159 0.934 rs2878608 chr4:1354286 C/G cg02018176 chr4:1364513 KIAA1530 0.38 6.14 0.32 2.41e-9 Longevity; CRC cis rs2559856 1.000 rs2559857 chr12:102089399 A/C cg12924262 chr12:102091054 CHPT1 0.54 8.15 0.41 7.8e-15 Blood protein levels; CRC cis rs10504229 0.728 rs78765835 chr8:58154337 A/G cg05313129 chr8:58192883 C8orf71 -0.47 -6.18 -0.32 1.94e-9 Developmental language disorder (linguistic errors); CRC cis rs11785400 0.793 rs9774627 chr8:143731267 G/A cg10596483 chr8:143751796 JRK 0.48 6.49 0.34 3.23e-10 Schizophrenia; CRC trans rs7395662 0.895 rs8186350 chr11:48739261 G/C cg21153622 chr11:89784906 NA -0.48 -7.72 -0.39 1.45e-13 HDL cholesterol; CRC cis rs8038465 0.622 rs17185294 chr15:73858415 C/T cg15420318 chr15:73925796 NPTN -0.46 -7.76 -0.39 1.1e-13 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs9611519 0.754 rs4820435 chr22:41652846 G/T cg06634786 chr22:41940651 POLR3H -0.44 -5.74 -0.3 2.13e-8 Neuroticism; CRC cis rs7712401 0.720 rs10075963 chr5:122185421 T/A cg18764291 chr5:122110994 SNX2 0.36 5.75 0.3 2.05e-8 Mean platelet volume; CRC cis rs34375054 0.687 rs35540170 chr12:125669122 C/G cg25124228 chr12:125621409 AACS -0.53 -6.71 -0.35 8.69e-11 Post bronchodilator FEV1/FVC ratio; CRC cis rs2576037 0.526 rs7240239 chr18:44460037 T/C cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.64 -10.41 -0.5 3.88e-22 Personality dimensions; CRC cis rs11763147 1 rs11763147 chr7:65326821 C/T cg18876405 chr7:65276391 NA -0.63 -11.87 -0.55 2.69e-27 Corneal structure; CRC cis rs5758511 0.680 rs5758688 chr22:42662501 T/C cg00645731 chr22:42541494 CYP2D7P1 0.64 9.83 0.48 3.73e-20 Birth weight; CRC cis rs72781680 0.821 rs17038360 chr2:24095798 A/G cg08917208 chr2:24149416 ATAD2B 0.55 6.65 0.34 1.25e-10 Lymphocyte counts; CRC cis rs11997175 0.624 rs6996590 chr8:33680486 A/G ch.8.33884649F chr8:33765107 NA 0.44 6.26 0.33 1.23e-9 Body mass index; CRC cis rs950169 0.580 rs2271431 chr15:85189464 A/C cg11189052 chr15:85197271 WDR73 0.67 9.98 0.48 1.16e-20 Schizophrenia; CRC cis rs1395 0.925 rs1659701 chr2:27414877 T/C cg23587288 chr2:27483067 SLC30A3 0.34 6.01 0.31 4.91e-9 Blood metabolite levels; CRC cis rs1552244 0.882 rs68153882 chr3:10013110 T/C cg00166722 chr3:10149974 C3orf24 0.61 7.96 0.4 2.85e-14 Alzheimer's disease; CRC trans rs3960554 0.610 rs10265696 chr7:75766712 G/A cg19862616 chr7:65841803 NCRNA00174 0.74 8.75 0.43 1.11e-16 Eotaxin levels; CRC cis rs6860806 0.632 rs4330455 chr5:131586349 T/C cg04518342 chr5:131593106 PDLIM4 0.45 8.34 0.42 2.07e-15 Breast cancer; CRC cis rs938554 0.784 rs11722229 chr4:9980697 C/A cg00071950 chr4:10020882 SLC2A9 0.46 6.51 0.34 2.83e-10 Blood metabolite levels; CRC cis rs1580019 0.665 rs34147895 chr7:32531796 G/C cg06627557 chr7:32535165 LSM5;AVL9 0.98 18.54 0.71 4.88e-53 Cognitive ability; CRC cis rs7113874 0.569 rs11041978 chr11:8578150 T/C cg20771178 chr11:8615675 STK33 -0.34 -5.61 -0.3 4.21e-8 Body mass index in physically active individuals;Body mass index (joint analysis main effects and physical activity interaction); CRC trans rs2797160 0.905 rs1418640 chr6:125999866 G/A cg05039488 chr6:79577232 IRAK1BP1 -0.5 -7.55 -0.38 4.4e-13 Endometrial cancer; CRC cis rs2522056 1.000 rs2106854 chr5:131769174 C/T cg24060327 chr5:131705240 SLC22A5 0.43 5.92 0.31 7.96e-9 Lymphocyte counts;Fibrinogen; CRC cis rs763121 0.886 rs1013339 chr22:38974680 C/T cg06544989 chr22:39130855 UNC84B 0.49 8.09 0.41 1.16e-14 Menopause (age at onset); CRC cis rs11123170 0.542 rs28522253 chr2:113967387 G/A cg12889195 chr2:113992843 PAX8;LOC440839;LOC654433 0.5 5.94 0.31 7.43e-9 Renal function-related traits (BUN); CRC cis rs6912958 0.559 rs451829 chr6:88041919 A/G cg08069147 chr6:88032118 GJB7;C6orf162 0.72 11.77 0.54 6.11e-27 Monocyte percentage of white cells; CRC cis rs9381040 0.610 rs2057002 chr6:41022962 G/T cg04346459 chr6:41068666 NFYA;LOC221442 -0.42 -6.28 -0.33 1.09e-9 Alzheimer's disease (late onset); CRC cis rs10207060 0.500 rs56346503 chr2:240719409 T/C cg07506560 chr2:240697449 NA 0.43 5.85 0.31 1.18e-8 Obesity-related traits; CRC cis rs11098499 0.697 rs10020027 chr4:120381879 G/C cg24375607 chr4:120327624 NA 0.5 7.73 0.39 1.3e-13 Corneal astigmatism; CRC cis rs3820068 0.581 rs68052904 chr1:15916714 T/C cg13390004 chr1:15929781 NA 0.5 6.84 0.35 3.94e-11 Systolic blood pressure; CRC cis rs12612619 0.732 rs1053609 chr2:27293150 G/T cg00617064 chr2:27272375 NA -0.38 -6.44 -0.33 4.17e-10 Venous thromboembolism adjusted for sickle cell variant rs77121243-T; CRC cis rs9292777 0.777 rs60343748 chr5:40394661 T/A cg09067459 chr5:40385259 NA -0.54 -8.99 -0.44 1.92e-17 Crohn's disease;Multiple sclerosis; CRC trans rs916888 0.738 rs199515 chr17:44856641 C/G cg23590916 chr17:43697445 MGC57346 -0.55 -6.05 -0.32 3.84e-9 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs2898290 0.506 rs2736311 chr8:11252170 C/T cg08071915 chr8:12219732 FAM66A 0.32 5.75 0.3 2.05e-8 Systolic blood pressure; CRC cis rs2245368 0.523 rs67814714 chr7:76517422 T/C cg15770687 chr7:76625569 PMS2L11 0.66 6.52 0.34 2.7e-10 Body mass index in physically inactive individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction);BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index (joint analysis main effects and smoking interaction); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg13894748 chr10:102107266 SCD 0.49 6.94 0.36 2.04e-11 Response to antipsychotic treatment; CRC cis rs7524258 0.868 rs4908607 chr1:7269323 A/G cg07173049 chr1:7289937 CAMTA1 0.59 10.01 0.48 9.17e-21 Tourette's syndrome or obsessive-compulsive disorder; CRC cis rs425277 0.585 rs3107156 chr1:2060630 T/C cg24578937 chr1:2090814 PRKCZ -0.48 -8.61 -0.43 3.14e-16 Height; CRC cis rs473651 1.000 rs473651 chr2:239335401 A/C cg21699342 chr2:239360505 ASB1 0.57 10.26 0.49 1.33e-21 Multiple system atrophy; CRC cis rs9583531 0.600 rs9521909 chr13:111362170 A/G cg24331049 chr13:111365604 ING1 0.57 7.92 0.4 3.6e-14 Coronary artery disease; CRC cis rs9916302 0.904 rs9904334 chr17:37468336 G/A cg15445000 chr17:37608096 MED1 -0.42 -9.22 -0.45 3.61e-18 Glomerular filtration rate (creatinine); CRC cis rs1862618 0.671 rs2034244 chr5:56242774 T/C cg20203395 chr5:56204925 C5orf35 0.54 7.36 0.38 1.45e-12 Initial pursuit acceleration; CRC cis rs9457247 0.508 rs2285147 chr6:167505548 G/A cg07741184 chr6:167504864 NA 0.39 6.89 0.35 2.92e-11 Crohn's disease; CRC cis rs6502050 0.835 rs3924780 chr17:80112978 G/A cg25804541 chr17:80189381 SLC16A3 -0.31 -5.97 -0.31 6.08e-9 Life satisfaction; CRC trans rs703108 0.731 rs7898954 chr10:22323646 A/G cg00763094 chr1:171455187 BAT2L2 -0.53 -6.24 -0.33 1.31e-9 Monocyte percentage of white cells; CRC cis rs9910055 0.762 rs184478 chr17:42209751 C/G cg10896456 chr17:42255109 ASB16;C17orf65 -0.47 -7.71 -0.39 1.51e-13 Total body bone mineral density; CRC cis rs6988985 0.728 rs7388251 chr8:143969208 T/C cg10324643 chr8:143916377 GML 0.38 6.17 0.32 1.96e-9 Plasma androstenedione levels in resected early stage-receptor positive breast cancer; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg14478610 chr2:127864964 BIN1 0.48 6.87 0.35 3.27e-11 Response to antipsychotic treatment; CRC cis rs9633740 1.000 rs7910643 chr10:82251769 G/A cg00277334 chr10:82204260 NA -0.54 -5.87 -0.31 1.08e-8 Post bronchodilator FEV1; CRC cis rs1800795 0.530 rs62449494 chr7:22758035 A/G cg05472934 chr7:22766657 IL6 0.45 6.33 0.33 8.09e-10 Cerebrospinal fluid clusterin levels in APOEe4- carriers; CRC trans rs951252 0.504 rs11734405 chr4:146081096 C/T cg23084309 chr19:6280164 MLLT1 0.46 6.27 0.33 1.14e-9 Hip circumference; CRC cis rs1018836 0.608 rs6998106 chr8:91479755 G/T cg16814680 chr8:91681699 NA -0.57 -8.48 -0.42 7.82e-16 Ejection fraction in Tripanosoma cruzi seropositivity; CRC cis rs10504229 0.728 rs17804822 chr8:58156276 T/C cg22535103 chr8:58192502 C8orf71 -0.7 -8.38 -0.42 1.56e-15 Developmental language disorder (linguistic errors); CRC cis rs713587 0.806 rs6737082 chr2:25138040 A/C cg22495460 chr2:25135724 ADCY3 -0.83 -15.43 -0.65 8.23e-41 Body mass index in non-asthmatics; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg08613594 chr2:201374742 KCTD18 0.45 6.33 0.33 8.02e-10 Anxiety disorder; CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg20175449 chr11:118123099 MPZL3 -0.52 -6.43 -0.33 4.45e-10 Diisocyanate-induced asthma; CRC cis rs7937682 0.924 rs7938360 chr11:111539875 A/G cg09085632 chr11:111637200 PPP2R1B -0.99 -20.41 -0.75 2.08e-60 Primary sclerosing cholangitis; CRC cis rs11098499 0.863 rs11736416 chr4:120431661 C/T cg09307838 chr4:120376055 NA 0.68 10.32 0.49 8.02e-22 Corneal astigmatism; CRC cis rs1552244 0.882 rs36006511 chr3:10054191 C/T cg10729496 chr3:10149963 C3orf24 0.51 6.6 0.34 1.68e-10 Alzheimer's disease; CRC cis rs7647973 0.580 rs4955432 chr3:49266772 C/T cg03060546 chr3:49711283 APEH 0.46 6.68 0.35 1.02e-10 Menarche (age at onset); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg00529697 chr5:75013131 C5orf37 0.35 6.44 0.33 4.27e-10 Liver disease severity in Alagille syndrome; CRC cis rs950169 0.959 rs12902070 chr15:84793558 T/C cg24253500 chr15:84953950 NA 0.37 6.3 0.33 9.58e-10 Schizophrenia; CRC cis rs798554 0.679 rs2533868 chr7:2886559 G/A cg19717773 chr7:2847554 GNA12 -0.41 -5.85 -0.31 1.2e-8 Height; CRC cis rs35306767 0.807 rs72778228 chr10:938435 A/G cg26597838 chr10:835615 NA 1.25 14.71 0.63 5.27e-38 Eosinophil percentage of granulocytes; CRC trans rs1656966 1.000 rs1656966 chr3:186466252 C/T cg17024643 chr1:214725274 PTPN14 0.38 6.06 0.32 3.72e-9 Myopia (pathological); CRC cis rs898097 0.841 rs4986122 chr17:80825500 C/T cg15664640 chr17:80829946 TBCD -0.68 -11.53 -0.54 4.47e-26 Breast cancer; CRC cis rs9902453 0.967 rs55748380 chr17:28469782 T/G cg26525008 chr17:28256777 EFCAB5;SSH2 0.55 8.37 0.42 1.7e-15 Coffee consumption (cups per day); CRC cis rs16867321 0.639 rs13028421 chr2:181444035 G/T cg23363182 chr2:181467187 NA 0.59 9.05 0.45 1.29e-17 Obesity; CRC cis rs7705042 0.796 rs1835965 chr5:141501771 G/A cg07392085 chr5:141489673 NDFIP1 0.47 7.42 0.38 1.03e-12 Asthma; CRC cis rs10751667 0.666 rs7483273 chr11:951127 T/C cg23136738 chr11:925521 AP2A2 -0.41 -6.92 -0.36 2.32e-11 Alzheimer's disease (late onset); CRC cis rs875971 0.825 rs4587224 chr7:65736182 G/A cg18876405 chr7:65276391 NA -0.5 -8.2 -0.41 5.45e-15 Aortic root size; CRC cis rs2070488 0.965 rs6796845 chr3:38567771 C/A cg01465620 chr3:38496096 LOC100128640;ACVR2B -0.9 -16.62 -0.68 1.91e-45 Electrocardiographic conduction measures; CRC cis rs6761276 0.674 rs3811056 chr2:113831183 T/C cg24553058 chr2:113831203 IL1F10 0.55 8.64 0.43 2.47e-16 Protein quantitative trait loci; CRC cis rs10207060 0.778 rs6543581 chr2:240702308 C/T cg20333904 chr2:240724165 NA 0.3 5.73 0.3 2.21e-8 Obesity-related traits; CRC cis rs7615952 0.641 rs6438951 chr3:125696999 A/G cg02772935 chr3:125709198 NA -0.48 -5.69 -0.3 2.78e-8 Blood pressure (smoking interaction); CRC cis rs9915657 0.840 rs10512582 chr17:70139393 A/C cg09344028 chr17:70110421 NA 0.45 7.09 0.36 8.31e-12 Thyroid hormone levels; CRC cis rs3126085 0.935 rs10749670 chr1:152220467 G/A cg09127314 chr1:152161683 NA 0.49 6.28 0.33 1.05e-9 Atopic dermatitis; CRC cis rs3858526 0.523 rs10838750 chr11:5886246 C/T cg13902645 chr11:5959945 NA 0.69 10.06 0.48 6.36e-21 DNA methylation (variation); CRC cis rs35110281 0.774 rs1003280 chr21:44997322 A/G cg04455712 chr21:45112962 RRP1B 0.4 7.84 0.4 6.44e-14 Mean corpuscular volume; CRC cis rs3749237 0.964 rs2352967 chr3:49871641 C/T cg03060546 chr3:49711283 APEH 0.43 6.36 0.33 6.89e-10 Resting heart rate; CRC cis rs6896969 0.504 rs10472332 chr5:40368373 T/G cg09067459 chr5:40385259 NA 0.46 8.03 0.4 1.71e-14 Multiple sclerosis; CRC cis rs597539 0.616 rs631001 chr11:68642974 C/T cg06028808 chr11:68637592 NA 0.38 5.82 0.31 1.39e-8 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs7772486 0.597 rs7746618 chr6:146281367 T/C cg13319975 chr6:146136371 FBXO30 0.63 9.13 0.45 7.26e-18 Lobe attachment (rater-scored or self-reported); CRC cis rs1552244 0.554 rs3732964 chr3:10048839 C/G cg02579736 chr3:10068473 FANCD2;CIDECP 0.68 9.51 0.46 4.18e-19 Alzheimer's disease; CRC cis rs4665809 1.000 rs4665816 chr2:26305094 G/C cg25036284 chr2:26402008 FAM59B -0.45 -5.96 -0.31 6.44e-9 Gut microbiome composition (summer); CRC cis rs1218582 0.596 rs4845676 chr1:154827861 C/G cg24250549 chr1:154909240 PMVK 0.44 6.47 0.34 3.58e-10 Prostate cancer; CRC cis rs4713118 0.539 rs200988 chr6:27819353 A/C cg15786705 chr6:28176104 NA 0.54 7.44 0.38 8.74e-13 Parkinson's disease; CRC cis rs477692 0.571 rs10764890 chr10:131347163 G/A cg05714579 chr10:131428358 MGMT 0.46 6.37 0.33 6.3e-10 Response to temozolomide; CRC trans rs62103177 0.733 rs62103193 chr18:77629217 C/T cg05926928 chr17:57297772 GDPD1 1.06 9.98 0.48 1.12e-20 Opioid sensitivity; CRC cis rs17401966 0.597 rs56221672 chr1:10247313 A/G cg19773385 chr1:10388646 KIF1B -0.5 -7.6 -0.39 3.1400000000000003e-13 Hepatocellular carcinoma; CRC cis rs7224685 1.000 rs1377807 chr17:4045440 C/G cg11204139 chr17:3907470 NA 0.43 5.99 0.31 5.45e-9 Type 2 diabetes; CRC cis rs1190552 0.846 rs1044503 chr14:102965996 A/G cg18135206 chr14:102964638 TECPR2 0.53 6.31 0.33 9.27e-10 Blood protein levels; CRC cis rs7119 0.700 rs4886883 chr15:77888924 C/T cg10437265 chr15:77819839 NA 0.49 8.44 0.42 1.02e-15 Type 2 diabetes; CRC cis rs881375 0.933 rs10818485 chr9:123667816 G/C cg09419670 chr9:123605666 PSMD5;LOC253039 0.6 8.81 0.44 7.32e-17 Rheumatoid arthritis; CRC cis rs13108904 0.539 rs13140926 chr4:1340939 G/A cg15763984 chr4:1342303 KIAA1530 0.45 6.83 0.35 4.02e-11 Obesity-related traits; CRC cis rs3750965 0.806 rs7107680 chr11:68859894 C/T cg06818126 chr11:68850279 TPCN2 -0.48 -6.81 -0.35 4.64e-11 Hair color; CRC cis rs17065868 0.764 rs17065818 chr13:45022180 T/C cg10246903 chr13:45222710 NA 0.6 6.53 0.34 2.45e-10 Antineutrophil cytoplasmic antibody-associated vasculitis; CRC cis rs6952808 0.723 rs60995052 chr7:2030007 G/C cg00106254 chr7:1943704 MAD1L1 -0.56 -8.2 -0.41 5.62e-15 Bipolar disorder and schizophrenia; CRC cis rs10504229 0.683 rs6980540 chr8:58127022 A/G cg05313129 chr8:58192883 C8orf71 -0.43 -6.0 -0.31 5.07e-9 Developmental language disorder (linguistic errors); CRC cis rs10504229 1.000 rs57941207 chr8:58169821 A/G cg22535103 chr8:58192502 C8orf71 -0.81 -11.98 -0.55 1.05e-27 Developmental language disorder (linguistic errors); CRC cis rs5753618 0.561 rs13054220 chr22:31704492 A/G cg22777020 chr22:31556080 RNF185 0.55 6.29 0.33 1.02e-9 Colorectal cancer; CRC cis rs7937682 0.924 rs7938360 chr11:111539875 A/G cg19812747 chr11:111475976 SIK2 -0.56 -9.73 -0.47 7.8500000000000006e-20 Primary sclerosing cholangitis; CRC cis rs1448094 0.511 rs10506923 chr12:86152595 C/T cg18827107 chr12:86230957 RASSF9 0.39 5.98 0.31 5.76e-9 Major depressive disorder; CRC cis rs9467711 0.606 rs4634439 chr6:26598004 C/T cg12315302 chr6:26189340 HIST1H4D -0.7 -5.84 -0.31 1.24e-8 Autism spectrum disorder or schizophrenia; CRC cis rs78456975 0.699 rs17091772 chr2:1519679 A/C cg26248373 chr2:1572462 NA -0.64 -8.07 -0.41 1.35e-14 Placebo response in major depressive disorder (% change in symptom score); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg15450734 chr14:103541957 NA 0.53 7.69 0.39 1.76e-13 Response to antipsychotic treatment; CRC cis rs9549328 0.614 rs35299896 chr13:113617229 G/T cg20742385 chr13:113633654 MCF2L 0.56 9.53 0.46 3.7e-19 Systolic blood pressure; CRC cis rs6694672 0.867 rs7534353 chr1:197096480 T/G cg13682187 chr1:196946512 CFHR5 0.48 7.58 0.39 3.5e-13 Asthma; CRC cis rs1448094 0.512 rs11117057 chr12:86248546 C/T cg25456477 chr12:86230367 RASSF9 0.34 5.99 0.31 5.54e-9 Major depressive disorder; CRC cis rs6496667 0.779 rs2301829 chr15:90992687 A/G cg04176472 chr15:90893244 GABARAPL3 0.58 8.16 0.41 7.06e-15 Rheumatoid arthritis; CRC cis rs2645694 0.911 rs2703147 chr4:77831307 C/T cg03477792 chr4:77819574 ANKRD56 0.45 6.56 0.34 2.07e-10 Emphysema distribution in smoking; CRC cis rs4853012 0.838 rs60705299 chr2:74345370 C/G cg19729930 chr2:74357872 NA 0.64 10.04 0.48 7.38e-21 Gestational age at birth (maternal effect); CRC cis rs514406 0.584 rs7548832 chr1:53193576 A/T cg08859206 chr1:53392774 SCP2 -0.41 -6.45 -0.33 4.1e-10 Monocyte count; CRC trans rs4942242 0.663 rs34978818 chr13:44214096 T/C cg19169023 chr15:41853346 TYRO3 -0.59 -8.33 -0.42 2.18e-15 Response to tocilizumab in rheumatoid arthritis; CRC cis rs7917772 0.582 rs10883753 chr10:104372441 C/T cg11453585 chr10:104263688 ACTR1A;SUFU 0.82 15.03 0.64 3.06e-39 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC cis rs4629180 1.000 rs6744495 chr2:102099956 T/C cg04415270 chr2:102091202 RFX8 -0.58 -8.21 -0.41 5.23e-15 Chronic rhinosinusitis with nasal polyps; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg01074628 chr11:74204917 LIPT2 0.5 6.43 0.33 4.48e-10 Thyroid stimulating hormone; CRC cis rs6500395 0.775 rs11640119 chr16:48662840 C/T cg04672837 chr16:48644449 N4BP1 0.43 6.33 0.33 7.93e-10 Response to tocilizumab in rheumatoid arthritis; CRC cis rs4654899 0.865 rs12130664 chr1:21332812 G/T cg02927042 chr1:21476669 EIF4G3 -0.5 -7.92 -0.4 3.72e-14 Superior frontal gyrus grey matter volume; CRC cis rs7666738 0.927 rs11736876 chr4:98987206 A/G cg03676636 chr4:99064102 C4orf37 0.24 6.67 0.35 1.08e-10 Colonoscopy-negative controls vs population controls; CRC cis rs2070488 0.662 rs7372545 chr3:38507570 T/G cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.58 8.55 0.43 4.65e-16 Electrocardiographic conduction measures; CRC cis rs55692411 0.517 rs13095697 chr3:50136463 G/A cg05623727 chr3:50126028 RBM5 0.54 6.88 0.35 2.94e-11 Intelligence (multi-trait analysis); CRC cis rs861020 1.000 rs642961 chr1:209989270 A/G cg09163369 chr1:210001066 C1orf107 0.59 7.28 0.37 2.49e-12 Orofacial clefts; CRC cis rs1799949 1.000 rs34534709 chr17:41302940 C/G cg19454999 chr17:41278357 BRCA1;NBR2 0.54 8.28 0.42 3.06e-15 Menopause (age at onset); CRC cis rs7666738 0.830 rs1869082 chr4:98841254 T/A cg05340658 chr4:99064831 C4orf37 0.55 7.99 0.4 2.22e-14 Colonoscopy-negative controls vs population controls; CRC cis rs12936587 0.569 rs8073683 chr17:17555596 C/T cg16928487 chr17:17741425 SREBF1 0.34 5.63 0.3 3.95e-8 Hip circumference;Coronary artery disease or large artery stroke;Coronary heart disease;Coronary artery disease; CRC cis rs9914544 0.966 rs7210746 chr17:18798593 T/C cg26378065 chr17:18585709 ZNF286B 0.42 5.82 0.31 1.39e-8 Educational attainment (years of education); CRC cis rs736801 0.808 rs2706403 chr5:131799012 A/G cg00255919 chr5:131827918 IRF1 0.36 6.11 0.32 2.81e-9 Breast cancer;Mosquito bite size; CRC cis rs853679 0.550 rs1233701 chr6:28168726 C/G cg02683197 chr6:28174875 NA -0.89 -12.85 -0.58 6.48e-31 Depression; CRC cis rs12931792 0.782 rs6565176 chr16:30174926 T/C cg17640201 chr16:30407289 ZNF48 0.44 6.38 0.33 6.16e-10 Tonsillectomy; CRC cis rs12745968 0.589 rs4970707 chr1:92986446 G/A cg17283838 chr1:93427260 FAM69A -0.47 -6.36 -0.33 6.83e-10 Bipolar disorder and schizophrenia; CRC cis rs6062302 0.522 rs3810492 chr20:62219740 G/A cg16989086 chr20:62203971 PRIC285 0.48 6.17 0.32 2.05e-9 Glioblastoma; CRC cis rs9322193 0.923 rs4870267 chr6:149992708 C/G cg13206674 chr6:150067644 NUP43 0.65 9.75 0.47 6.68e-20 Lung cancer; CRC cis rs2070997 0.702 rs2841177 chr9:133764207 C/T cg01000188 chr9:133769184 QRFP 0.56 5.69 0.3 2.81e-8 Response to amphetamines; CRC cis rs4731207 0.698 rs6960504 chr7:124530314 A/G cg23710748 chr7:124431027 NA -0.37 -5.9 -0.31 9.08e-9 Cutaneous malignant melanoma; CRC cis rs10905065 0.895 rs1858447 chr10:5852230 A/G cg11519256 chr10:5708881 ASB13 -0.42 -6.12 -0.32 2.69e-9 Menopause (age at onset); CRC cis rs28386778 0.799 rs2584612 chr17:61932204 A/G cg23090583 chr17:61904693 PSMC5;FTSJ3 1.03 19.93 0.74 1.63e-58 Prudent dietary pattern; CRC cis rs1559088 0.948 rs10408093 chr19:33597816 T/C cg27124370 chr19:33622961 WDR88 0.45 6.34 0.33 7.42e-10 Bone ultrasound measurement (broadband ultrasound attenuation); CRC cis rs2046867 0.908 rs62251649 chr3:72809610 A/C cg25664220 chr3:72788482 NA -0.46 -6.39 -0.33 5.6e-10 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; CRC cis rs853679 0.517 rs9393885 chr6:28050009 A/T cg06470822 chr6:28175283 NA 0.98 13.34 0.59 9.69e-33 Depression; CRC cis rs3204270 0.684 rs57405099 chr17:79637065 T/C cg09655341 chr17:79618100 PDE6G 0.56 6.58 0.34 1.81e-10 Dental caries; CRC cis rs2952156 0.920 rs12940986 chr17:37836581 A/G cg11212589 chr17:38028394 ZPBP2 -0.34 -5.95 -0.31 6.86e-9 Asthma; CRC trans rs7580658 0.614 rs7585198 chr2:127962635 C/T cg06007323 chr4:6784769 KIAA0232 -0.46 -6.31 -0.33 8.8e-10 Protein C levels; CRC cis rs9611565 0.729 rs132902 chr22:41797758 A/G cg06634786 chr22:41940651 POLR3H -0.52 -6.08 -0.32 3.26e-9 Vitiligo; CRC cis rs4253772 0.513 rs9615345 chr22:46713631 C/T cg24881330 chr22:46731750 TRMU 0.66 7.69 0.39 1.73e-13 LDL cholesterol;Cholesterol, total; CRC cis rs9322193 0.962 rs1112730 chr6:150087519 G/A cg00933542 chr6:150070202 PCMT1 0.28 5.69 0.3 2.75e-8 Lung cancer; CRC cis rs17384381 1.000 rs12133722 chr1:85873237 C/T cg16011679 chr1:85725395 C1orf52 0.64 6.63 0.34 1.37e-10 Lobe attachment (rater-scored or self-reported); CRC cis rs12999616 0.948 rs35958372 chr2:98330858 T/C cg26665480 chr2:98280029 ACTR1B 0.64 7.29 0.37 2.31e-12 Colorectal cancer; CRC cis rs67311347 1.000 rs7633809 chr3:40517737 A/G cg09455208 chr3:40491958 NA -0.47 -9.51 -0.46 4.15e-19 Renal cell carcinoma; CRC cis rs3806843 0.576 rs246007 chr5:140338748 C/T cg19875535 chr5:140030758 IK 0.4 6.12 0.32 2.64e-9 Depressive symptoms (multi-trait analysis); CRC cis rs6860806 0.507 rs273912 chr5:131661349 A/C cg11843238 chr5:131593191 PDLIM4 -0.43 -7.39 -0.38 1.26e-12 Breast cancer; CRC cis rs734999 0.549 rs6670198 chr1:2520527 T/C cg18854424 chr1:2615690 NA 0.48 9.43 0.46 7.65e-19 Ulcerative colitis; CRC cis rs17253792 0.822 rs13379342 chr14:56050452 A/G cg01858014 chr14:56050164 KTN1 -0.92 -8.25 -0.41 3.95e-15 Putamen volume; CRC cis rs11098499 0.954 rs6849561 chr4:120409694 C/G cg24375607 chr4:120327624 NA -0.51 -7.6 -0.39 3.13e-13 Corneal astigmatism; CRC cis rs76993477 0.666 rs76991533 chr1:169711577 T/C cg03211132 chr1:169703751 SELE 0.58 5.7 0.3 2.72e-8 Tonsillectomy; CRC cis rs2050392 0.858 rs2250569 chr10:30698914 G/C cg25182066 chr10:30743637 MAP3K8 -0.38 -5.78 -0.3 1.78e-8 Inflammatory bowel disease; CRC cis rs2404602 0.647 rs1443115 chr15:77041829 T/C cg03037974 chr15:76606532 NA -0.54 -7.78 -0.39 9.15e-14 Blood metabolite levels; CRC cis rs4132509 0.744 rs12047209 chr1:243954407 A/C cg21452805 chr1:244014465 NA 0.6 6.21 0.32 1.63e-9 RR interval (heart rate); CRC cis rs9522267 0.502 rs9515450 chr13:112234262 T/C cg26182253 chr13:112236782 NA 0.31 6.28 0.33 1.09e-9 Hepatitis; CRC cis rs7119 0.637 rs2667775 chr15:77864802 T/G cg27398640 chr15:77910606 LINGO1 0.45 7.72 0.39 1.45e-13 Type 2 diabetes; CRC cis rs10883723 0.810 rs3740406 chr10:104272789 C/T cg04362960 chr10:104952993 NT5C2 -0.45 -6.3 -0.33 9.48e-10 Allergic disease (asthma, hay fever or eczema); CRC cis rs9534288 0.742 rs1022953 chr13:46649126 G/T cg15192986 chr13:46630673 CPB2 -0.7 -9.34 -0.46 1.46e-18 Blood protein levels; CRC cis rs3796619 0.961 rs62294748 chr4:1082999 G/A cg11579758 chr4:1086637 RNF212 0.41 6.67 0.35 1.06e-10 Recombination rate (males); CRC cis rs9322193 0.884 rs2342858 chr6:150127103 C/T cg05861140 chr6:150128134 PCMT1 -0.43 -7.01 -0.36 1.32e-11 Lung cancer; CRC cis rs449789 0.857 rs2451988 chr6:159714390 G/A cg14500486 chr6:159655392 FNDC1 -0.48 -7.4 -0.38 1.13e-12 Pulse pressure; CRC cis rs7255436 0.965 rs11668346 chr19:8450854 A/T cg10174797 chr19:8464628 RAB11B 0.44 7.7 0.39 1.62e-13 HDL cholesterol; CRC cis rs13108904 0.935 rs4974575 chr4:1252028 A/G cg19318889 chr4:1322082 MAEA 0.46 6.9 0.36 2.62e-11 Obesity-related traits; CRC cis rs9914988 0.943 rs9913801 chr17:27132105 G/A cg20469991 chr17:27169893 C17orf63 -0.6 -7.27 -0.37 2.59e-12 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg15662616 chr7:148823355 ZNF425;ZNF398 0.44 6.63 0.34 1.34e-10 Intelligence (multi-trait analysis); CRC cis rs11212617 0.967 rs1583598 chr11:108305989 G/A cg12106634 chr11:108092400 ATM;NPAT 0.39 5.68 0.3 3.01e-8 Response to metformin in type 2 diabetes (glycemic); CRC cis rs9341808 0.754 rs10733162 chr6:81023389 G/A cg08355045 chr6:80787529 NA 0.35 5.7 0.3 2.74e-8 Sitting height ratio; CRC cis rs2179367 0.887 rs2143076 chr6:149746451 G/A cg07828024 chr6:149772892 ZC3H12D -0.35 -5.8 -0.3 1.59e-8 Dupuytren's disease; CRC cis rs853679 0.517 rs9380047 chr6:28037893 G/T cg02631126 chr6:28058918 ZSCAN12L1 0.29 6.1 0.32 2.93e-9 Depression; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg08351143 chr9:33817857 UBE2R2 0.46 6.27 0.33 1.12e-9 Response to antipsychotic treatment; CRC cis rs6459788 0.720 rs11974772 chr7:157250645 G/A cg06271696 chr7:157225062 NA -0.57 -9.65 -0.47 1.5e-19 Epstein-Barr virus copy number in lymphoblastoid cell lines; CRC cis rs1348850 0.651 rs1901826 chr2:178225266 G/A cg22681709 chr2:178499509 PDE11A -0.33 -6.14 -0.32 2.36e-9 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs4713118 0.539 rs200967 chr6:27862127 A/G cg20615401 chr6:28092323 ZSCAN16 0.44 5.76 0.3 1.95e-8 Parkinson's disease; CRC cis rs10504229 0.815 rs17805008 chr8:58160185 G/T cg08219700 chr8:58056026 NA 0.45 5.63 0.3 3.88e-8 Developmental language disorder (linguistic errors); CRC cis rs910316 1.000 rs10136948 chr14:75511075 C/T cg11812906 chr14:75593930 NEK9 0.67 10.77 0.51 2.23e-23 Height; CRC cis rs2439831 0.850 rs16963953 chr15:44081719 A/T cg02155558 chr15:43621948 ADAL;LCMT2 0.66 7.08 0.36 8.77e-12 Lung cancer in ever smokers; CRC cis rs9381040 0.655 rs6939989 chr6:41020205 A/G cg04346459 chr6:41068666 NFYA;LOC221442 -0.39 -5.87 -0.31 1.04e-8 Alzheimer's disease (late onset); CRC cis rs4819052 0.851 rs2838831 chr21:46664775 C/T cg19498844 chr21:46707878 POFUT2;LOC642852 0.77 11.44 0.53 9.92e-26 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs425277 0.606 rs262664 chr1:2083537 G/C cg21194808 chr1:2205498 SKI 0.4 5.91 0.31 8.73e-9 Height; CRC cis rs6543140 0.865 rs6760275 chr2:103079607 C/T cg04239558 chr2:103089729 SLC9A4 0.37 6.59 0.34 1.72e-10 Blood protein levels; CRC trans rs9341835 0.772 rs6919709 chr6:64139856 C/T cg13657004 chr13:50234944 EBPL -0.37 -6.25 -0.33 1.3e-9 Schizophrenia; CRC cis rs7843479 1.000 rs66824050 chr8:21815425 T/G cg17168535 chr8:21777572 XPO7 0.55 8.84 0.44 5.94e-17 Mean corpuscular volume; CRC cis rs1218582 0.804 rs869506 chr1:154859581 A/C cg03351412 chr1:154909251 PMVK 0.54 8.68 0.43 1.81e-16 Prostate cancer; CRC cis rs12638540 0.543 rs12487678 chr3:32603358 A/C cg11605617 chr3:32612461 DYNC1LI1 0.68 5.81 0.31 1.47e-8 Mortality in heart failure; CRC cis rs270601 0.913 rs273899 chr5:131695178 G/A cg18301423 chr5:131593218 PDLIM4 0.39 6.46 0.34 3.77e-10 Acylcarnitine levels; CRC cis rs4713118 0.662 rs9357060 chr6:28024486 C/G cg12273811 chr6:28175739 NA 0.63 8.44 0.42 9.98e-16 Parkinson's disease; CRC trans rs7580658 0.614 rs7585198 chr2:127962635 C/T cg18122411 chr2:122513043 TSN -0.43 -6.03 -0.32 4.51e-9 Protein C levels; CRC cis rs10256972 0.621 rs10951594 chr7:1088607 C/G cg04025307 chr7:1156635 C7orf50 0.47 7.26 0.37 2.84e-12 Longevity;Endometriosis; CRC trans rs2303319 0.504 rs12470743 chr2:162611202 G/A cg27342122 chr8:133787442 PHF20L1 -0.72 -6.12 -0.32 2.68e-9 Cognitive function; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg02787772 chr8:26435434 DPYSL2 0.41 6.0 0.31 5.13e-9 Intelligence (multi-trait analysis); CRC cis rs892085 0.681 rs3826803 chr19:10883126 C/G cg17710535 chr19:10819994 QTRT1 -0.39 -5.99 -0.31 5.57e-9 Psoriasis vulgaris;Psoriasis; CRC cis rs2302190 0.882 rs8072873 chr17:56669049 G/C cg25885038 chr17:56607967 SEPT4 -0.51 -7.7 -0.39 1.63e-13 Vitamin D levels; CRC cis rs28386778 0.897 rs2854214 chr17:61945449 C/G cg06873352 chr17:61820015 STRADA -0.78 -14.91 -0.64 8.94e-39 Prudent dietary pattern; CRC cis rs6951245 1.000 rs77868187 chr7:1093968 A/C cg26224354 chr7:1096374 C7orf50;GPR146 -0.94 -12.22 -0.56 1.4e-28 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC trans rs4942242 0.663 rs9525816 chr13:44223898 A/G cg19169023 chr15:41853346 TYRO3 -0.61 -8.59 -0.43 3.43e-16 Response to tocilizumab in rheumatoid arthritis; CRC cis rs2252521 0.524 rs2074782 chr7:29070653 C/T cg11728747 chr7:29037910 CPVL -0.5 -7.21 -0.37 3.86e-12 Cognitive performance; CRC cis rs4141404 0.923 rs2413046 chr22:31665909 C/A cg07713946 chr22:31675144 LIMK2 -0.4 -5.68 -0.3 2.98e-8 Paclitaxel-induced neuropathy; CRC cis rs12545109 0.800 rs973548 chr8:57416402 C/T cg09654669 chr8:57350985 NA -0.44 -7.05 -0.36 1.06e-11 Obesity-related traits; CRC cis rs9549367 0.737 rs11619691 chr13:113904636 T/C cg00898013 chr13:113819073 PROZ -0.46 -6.47 -0.34 3.56e-10 Platelet distribution width; CRC cis rs7085104 0.700 rs6163 chr10:104596924 C/A cg15744005 chr10:104629667 AS3MT -0.35 -7.53 -0.38 5.06e-13 Immature fraction of reticulocytes;Schizophrenia; CRC cis rs2832077 0.527 rs2738953 chr21:30238363 G/C cg24692254 chr21:30365293 RNF160 0.45 6.7 0.35 8.97e-11 Cognitive test performance; CRC cis rs9303280 0.806 rs12709365 chr17:38027400 A/G cg11212589 chr17:38028394 ZPBP2 0.43 7.93 0.4 3.34e-14 Self-reported allergy; CRC cis rs1799949 0.965 rs9646418 chr17:41425901 A/G cg07153921 chr17:41440717 NA -0.37 -5.73 -0.3 2.3e-8 Menopause (age at onset); CRC cis rs1048238 0.818 rs945421 chr1:16345393 T/C cg22431228 chr1:16359049 CLCNKA -0.43 -8.35 -0.42 1.88e-15 Systolic blood pressure; CRC trans rs11098499 0.866 rs7665125 chr4:120402079 G/T cg25214090 chr10:38739885 LOC399744 0.59 9.43 0.46 7.85e-19 Corneal astigmatism; CRC cis rs6433857 0.536 rs4625864 chr2:181353942 G/C cg23363182 chr2:181467187 NA -0.55 -8.27 -0.41 3.36e-15 Body mass index; CRC cis rs853679 0.882 rs9366717 chr6:28191057 C/T cg15845792 chr6:28175446 NA 0.8 6.39 0.33 5.67e-10 Depression; CRC cis rs6461049 0.800 rs3800913 chr7:2163237 A/G cg02951883 chr7:2050386 MAD1L1 -0.6 -9.6 -0.47 2.14e-19 Schizophrenia; CRC cis rs1707322 1.000 rs11211244 chr1:46456673 G/A cg03146154 chr1:46216737 IPP 0.51 7.15 0.37 5.54e-12 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs10791323 0.628 rs2851118 chr11:133705995 A/C cg15485101 chr11:133734466 NA 0.4 6.91 0.36 2.45e-11 Childhood ear infection; CRC cis rs11997175 0.574 rs4520125 chr8:33648628 C/T ch.8.33884649F chr8:33765107 NA 0.47 7.45 0.38 8.11e-13 Body mass index; CRC cis rs514406 0.929 rs515857 chr1:53336859 A/G cg24675658 chr1:53192096 ZYG11B -0.53 -7.86 -0.4 5.47e-14 Monocyte count; CRC cis rs7786808 0.649 rs6459879 chr7:158211792 C/G cg17401720 chr7:158221031 PTPRN2 0.42 7.07 0.36 9.4e-12 Obesity-related traits; CRC cis rs7209700 0.547 rs7217214 chr17:45355227 T/C cg08085267 chr17:45401833 C17orf57 0.54 6.43 0.33 4.52e-10 IgG glycosylation; CRC trans rs208520 0.661 rs150263 chr6:66777620 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.04 -14.86 -0.63 1.39e-38 Exhaled nitric oxide output; CRC cis rs7584330 0.554 rs7559057 chr2:238435306 A/T cg14458575 chr2:238380390 NA 0.52 6.86 0.35 3.51e-11 Prostate cancer; CRC trans rs12887734 0.524 rs4906364 chr14:104214342 C/G cg06206626 chr22:26825900 ASPHD2 0.42 6.23 0.32 1.39e-9 Schizophrenia;Autism spectrum disorder or schizophrenia; CRC cis rs7224685 0.501 rs781845 chr17:3958341 A/G cg09597638 chr17:3907349 NA -0.64 -11.54 -0.54 4.26e-26 Type 2 diabetes; CRC cis rs4862750 0.914 rs10027250 chr4:187873460 T/C cg22105103 chr4:187893119 NA 0.59 10.4 0.5 4.36e-22 Lobe attachment (rater-scored or self-reported); CRC cis rs2072510 0.593 rs2660900 chr12:96405077 T/C cg15438951 chr12:96389694 HAL -0.48 -5.83 -0.31 1.32e-8 Metabolite levels (small molecules and protein measures); CRC trans rs11026407 0.967 rs7127246 chr11:22060228 C/G cg02077165 chr1:28241257 RPA2 -0.6 -6.02 -0.31 4.54e-9 Plasma thyroid-stimulating hormone levels; CRC cis rs8180040 0.726 rs2385867 chr3:47059323 C/T cg27129171 chr3:47204927 SETD2 0.77 12.86 0.58 6.33e-31 Colorectal cancer; CRC cis rs1552244 0.882 rs13066757 chr3:10045030 C/A cg18598329 chr3:10140678 FANCD2;C3orf24 -0.81 -10.64 -0.51 6.69e-23 Alzheimer's disease; CRC cis rs10078 0.571 rs2721028 chr5:443849 A/G cg08916839 chr5:415575 AHRR 0.85 8.42 0.42 1.21e-15 Fat distribution (HIV); CRC cis rs4930561 0.714 rs7130844 chr11:67927517 C/T cg04465784 chr11:67976953 SUV420H1 -0.3 -6.13 -0.32 2.54e-9 Breast cancer in childhood cancer survivors;IgG glycosylation; CRC cis rs9894429 0.505 rs35570626 chr17:79611084 A/G cg21028142 chr17:79581711 NPLOC4 0.34 7.1 0.36 7.88e-12 Eye color traits; CRC cis rs116095464 0.558 rs6555055 chr5:226160 A/C cg22857025 chr5:266934 NA -1.21 -16.66 -0.68 1.3e-45 Breast cancer; CRC cis rs394563 0.619 rs4895787 chr6:149646500 G/A cg07828024 chr6:149772892 ZC3H12D 0.48 8.82 0.44 7.05e-17 Dupuytren's disease; CRC cis rs17376456 0.877 rs10514380 chr5:93409370 C/T cg21475434 chr5:93447410 FAM172A 0.72 7.73 0.39 1.31e-13 Diabetic retinopathy; CRC cis rs62064224 0.589 rs8069673 chr17:30661250 C/T cg18200150 chr17:30822561 MYO1D -0.46 -9.06 -0.45 1.19e-17 Schizophrenia; CRC cis rs10504229 0.593 rs17794451 chr8:58019217 C/T cg08219700 chr8:58056026 NA 0.55 6.5 0.34 2.99e-10 Developmental language disorder (linguistic errors); CRC cis rs17162190 0.590 rs6669111 chr1:26828182 A/G cg17456097 chr1:26900765 RPS6KA1 0.41 5.99 0.31 5.4e-9 Mean corpuscular volume; CRC cis rs62064224 0.675 rs12150479 chr17:30636200 T/A cg25809561 chr17:30822961 MYO1D 0.52 9.43 0.46 7.81e-19 Schizophrenia; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg00172330 chr1:28052294 FAM76A 0.45 6.02 0.31 4.54e-9 Anxiety disorder; CRC cis rs6860806 0.632 rs4330455 chr5:131586349 T/C cg09877947 chr5:131593287 PDLIM4 0.44 8.15 0.41 7.61e-15 Breast cancer; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg25104457 chr1:26201866 NA 0.38 6.0 0.31 5.28e-9 Liver disease severity in Alagille syndrome; CRC cis rs2839186 0.933 rs4818832 chr21:47708634 C/T cg09417038 chr21:47716443 C21orf57 -0.42 -6.93 -0.36 2.21e-11 Testicular germ cell tumor; CRC cis rs7789940 0.904 rs6948661 chr7:75961647 T/C cg10167463 chr7:75959203 YWHAG -0.78 -11.29 -0.53 3.41e-25 Multiple sclerosis; CRC cis rs1046896 0.739 rs28459016 chr17:80741194 G/A cg03160526 chr17:80928410 B3GNTL1 0.51 6.92 0.36 2.37e-11 Glycated hemoglobin levels; CRC trans rs6703335 0.870 rs10803142 chr1:243598234 A/G cg05047319 chr11:86748661 TMEM135 0.51 7.32 0.37 1.89e-12 Schizophrenia;Schizophrenia, schizoaffective disorder or bipolar disorder; CRC cis rs10197940 0.578 rs2045025 chr2:152317531 T/C cg19508488 chr2:152266495 RIF1 0.48 6.95 0.36 1.99e-11 Lung cancer; CRC cis rs3741151 0.773 rs73542976 chr11:73127471 A/G cg17517138 chr11:73019481 ARHGEF17 0.92 7.7 0.39 1.63e-13 GIP levels in response to oral glucose tolerance test (120 minutes); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg18644834 chr5:72861711 UTP15;ANKRA2 0.43 6.2 0.32 1.69e-9 Intelligence (multi-trait analysis); CRC cis rs10504229 1.000 rs57941207 chr8:58169821 A/G cg02725872 chr8:58115012 NA -0.37 -6.24 -0.33 1.33e-9 Developmental language disorder (linguistic errors); CRC cis rs4332037 0.538 rs6951956 chr7:1934131 C/T cg23422044 chr7:1970798 MAD1L1 -0.52 -6.98 -0.36 1.61e-11 Bipolar disorder; CRC cis rs9911578 0.967 rs8182277 chr17:57144367 C/T cg05425664 chr17:57184151 TRIM37 -0.51 -8.03 -0.4 1.73e-14 Intelligence (multi-trait analysis); CRC cis rs6570726 0.905 rs452770 chr6:145847162 T/C cg23711669 chr6:146136114 FBXO30 0.68 12.3 0.56 7.07e-29 Lobe attachment (rater-scored or self-reported); CRC cis rs6570726 0.791 rs425999 chr6:145819370 C/A cg13319975 chr6:146136371 FBXO30 -0.44 -6.66 -0.34 1.13e-10 Lobe attachment (rater-scored or self-reported); CRC cis rs2180341 0.722 rs9388555 chr6:127576363 G/A cg24812749 chr6:127587940 RNF146 0.78 11.39 0.53 1.5e-25 Breast cancer; CRC cis rs2949837 0.504 rs2342396 chr7:45968087 C/G cg21268650 chr7:45961089 IGFBP3 0.35 6.07 0.32 3.56e-9 Sitting height ratio; CRC cis rs4713118 0.547 rs2116981 chr6:28067951 T/G cg02683197 chr6:28174875 NA 0.82 10.05 0.48 6.9e-21 Parkinson's disease; CRC cis rs4731207 0.536 rs2127967 chr7:124605672 A/G cg23710748 chr7:124431027 NA -0.38 -6.08 -0.32 3.35e-9 Cutaneous malignant melanoma; CRC cis rs4713118 0.539 rs200951 chr6:27835930 A/G cg10876282 chr6:28092338 ZSCAN16 0.44 5.83 0.31 1.3e-8 Parkinson's disease; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg17158059 chr2:55746762 CCDC104 0.48 6.21 0.32 1.6e-9 Thyroid stimulating hormone; CRC trans rs61931739 0.500 rs10844734 chr12:34043083 G/A cg26384229 chr12:38710491 ALG10B 0.51 6.88 0.35 3.1e-11 Morning vs. evening chronotype; CRC cis rs523522 0.962 rs10849758 chr12:120971149 C/T cg27279351 chr12:120934652 DYNLL1 0.78 11.48 0.53 7.05e-26 High light scatter reticulocyte count; CRC cis rs17376456 0.877 rs17316137 chr5:93456577 C/T cg25358565 chr5:93447407 FAM172A 1.06 11.25 0.53 4.8e-25 Diabetic retinopathy; CRC cis rs2204008 0.805 rs11522896 chr12:38234427 T/C cg13010199 chr12:38710504 ALG10B 0.46 5.85 0.31 1.19e-8 Bladder cancer; CRC cis rs919433 0.963 rs1366837 chr2:198160501 T/C cg10820045 chr2:198174542 NA -0.57 -11.46 -0.53 8.38e-26 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC cis rs911119 0.955 rs55897275 chr20:23595953 A/T cg16589663 chr20:23618590 CST3 0.44 6.16 0.32 2.12e-9 Chronic kidney disease; CRC cis rs1256061 0.624 rs1152582 chr14:64692630 G/C cg23250157 chr14:64679961 SYNE2 0.46 7.14 0.37 6.03e-12 Hemoglobin concentration;Red blood cell count;Hematocrit; CRC cis rs1865760 0.613 rs9295674 chr6:25912342 A/G cg17691542 chr6:26056736 HIST1H1C 0.45 6.9 0.36 2.69e-11 Height; CRC cis rs2032447 0.714 rs199734 chr6:25940393 G/C cg12310025 chr6:25882481 NA -0.64 -9.25 -0.45 2.88e-18 Intelligence (multi-trait analysis); CRC cis rs9916302 0.851 rs7225096 chr17:37664443 T/C cg07936489 chr17:37558343 FBXL20 -0.84 -13.24 -0.59 2.32e-32 Glomerular filtration rate (creatinine); CRC cis rs4664293 0.967 rs13397722 chr2:160515651 G/A cg08347373 chr2:160653686 CD302 -0.47 -7.46 -0.38 7.7e-13 Monocyte percentage of white cells; CRC cis rs72772090 0.539 rs11741100 chr5:96113245 G/A cg17330273 chr5:96107758 CAST;ERAP1 -0.66 -6.14 -0.32 2.44e-9 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg15739944 chr9:99212660 HABP4 0.44 6.49 0.34 3.17e-10 Intelligence (multi-trait analysis); CRC cis rs1018836 0.851 rs6986359 chr8:91643162 A/G cg16814680 chr8:91681699 NA -0.76 -11.89 -0.55 2.35e-27 Ejection fraction in Tripanosoma cruzi seropositivity; CRC trans rs7819412 0.521 rs2409720 chr8:11037903 A/C cg06636001 chr8:8085503 FLJ10661 -0.5 -7.38 -0.38 1.26e-12 Triglycerides; CRC cis rs6500395 1.000 rs8052640 chr16:48604096 G/T cg04672837 chr16:48644449 N4BP1 0.45 6.64 0.34 1.32e-10 Response to tocilizumab in rheumatoid arthritis; CRC cis rs172166 0.769 rs149965 chr6:28018689 T/A cg06470822 chr6:28175283 NA 0.8 11.89 0.55 2.23e-27 Cardiac Troponin-T levels; CRC cis rs8067545 1.000 rs2108979 chr17:19928566 G/A cg13482628 chr17:19912719 NA 0.54 8.59 0.43 3.65e-16 Schizophrenia; CRC cis rs9858542 0.953 rs11710037 chr3:49675334 C/G cg00383909 chr3:49044727 WDR6 0.48 5.92 0.31 7.98e-9 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC trans rs1814175 0.717 rs11040450 chr11:49650638 G/A cg15704280 chr7:45808275 SEPT13 -0.97 -18.29 -0.71 4.7e-52 Height; CRC cis rs1712517 0.873 rs7916056 chr10:104997914 T/C cg05636881 chr10:105038444 INA -0.45 -7.84 -0.4 6.27e-14 Migraine; CRC cis rs2180341 0.751 rs9388553 chr6:127574044 A/G cg24812749 chr6:127587940 RNF146 0.78 11.39 0.53 1.5e-25 Breast cancer; CRC cis rs8141529 0.509 rs5762864 chr22:29253364 T/C cg02153584 chr22:29168773 CCDC117 0.52 7.45 0.38 8.13e-13 Lymphocyte counts; CRC cis rs5753618 0.561 rs2283879 chr22:31638448 G/A cg22777020 chr22:31556080 RNF185 -0.51 -5.94 -0.31 7.35e-9 Colorectal cancer; CRC cis rs6951245 0.872 rs113119264 chr7:1080564 G/A cg18402987 chr7:1209562 NA 0.64 6.78 0.35 5.48e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs2204008 0.774 rs4534658 chr12:38246783 G/A cg26384229 chr12:38710491 ALG10B 0.67 9.08 0.45 1.05e-17 Bladder cancer; CRC cis rs9926296 0.572 rs8046872 chr16:89841552 T/C cg27121462 chr16:89883253 FANCA 0.4 6.05 0.32 3.87e-9 Vitiligo; CRC cis rs881375 1.000 rs4323544 chr9:123647377 C/T cg09419670 chr9:123605666 PSMD5;LOC253039 0.59 8.63 0.43 2.75e-16 Rheumatoid arthritis; CRC cis rs1448094 0.967 rs7313443 chr12:86332940 G/A cg02569458 chr12:86230093 RASSF9 0.37 6.47 0.34 3.47e-10 Major depressive disorder; CRC cis rs17711722 0.523 rs313812 chr7:65505043 T/C cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.65 -10.34 -0.5 6.8e-22 Calcium levels; CRC cis rs6952808 0.792 rs2056478 chr7:1953897 C/T cg20295408 chr7:1910781 MAD1L1 -0.44 -6.07 -0.32 3.45e-9 Bipolar disorder and schizophrenia; CRC cis rs13191362 1.000 rs7769686 chr6:163199467 A/G cg23758597 chr6:163146217 PARK2 -0.66 -6.79 -0.35 5.28e-11 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs9467773 0.620 rs2101581 chr6:26622769 G/T cg09904177 chr6:26538194 HMGN4 0.72 11.29 0.53 3.4e-25 Intelligence (multi-trait analysis); CRC cis rs4478858 0.684 rs3737755 chr1:31744168 G/A cg00250761 chr1:31883323 NA -0.4 -7.65 -0.39 2.23e-13 Alcohol dependence; CRC trans rs916888 0.610 rs199453 chr17:44800946 C/T cg01341218 chr17:43662625 NA 0.59 7.39 0.38 1.21e-12 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs7917772 0.503 rs11191320 chr10:104293394 T/C cg11453585 chr10:104263688 ACTR1A;SUFU 0.9 16.75 0.68 5.87e-46 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC cis rs11758351 1.000 rs17598927 chr6:26184640 C/G cg16070018 chr6:26224392 HIST1H3E -0.58 -5.8 -0.3 1.54e-8 Gout;Renal underexcretion gout; CRC cis rs2976388 0.590 rs10087426 chr8:143814554 G/A cg04969067 chr8:143858791 LYNX1 -0.42 -6.65 -0.34 1.22e-10 Urinary tract infection frequency; CRC cis rs28374715 0.681 rs7163989 chr15:41614621 A/G cg18705301 chr15:41695430 NDUFAF1 -0.86 -14.31 -0.62 1.88e-36 Ulcerative colitis; CRC cis rs8060686 0.641 rs79323429 chr16:68084594 A/G cg26727032 chr16:67993705 SLC12A4 -0.58 -6.56 -0.34 2.04e-10 HDL cholesterol;Metabolic syndrome; CRC cis rs875971 0.617 rs810400 chr7:66022889 G/C cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.43 -6.46 -0.34 3.8e-10 Aortic root size; CRC cis rs7212590 0.655 rs8070039 chr17:57973585 G/C cg10252138 chr17:58120427 NA -0.6 -6.09 -0.32 3.21e-9 Granulocyte percentage of myeloid white cells;Monocyte count;Monocyte percentage of white cells; CRC trans rs2727020 0.701 rs7949044 chr11:49597334 C/T cg11707556 chr5:10655725 ANKRD33B -0.38 -6.31 -0.33 9.23e-10 Coronary artery disease; CRC cis rs62458065 0.713 rs62463968 chr7:32501242 G/A cg20159608 chr7:32802032 NA -0.61 -7.64 -0.39 2.41e-13 Metabolite levels (HVA/MHPG ratio); CRC cis rs2050392 0.894 rs303430 chr10:30706235 C/A cg18806716 chr10:30721971 MAP3K8 -0.5 -7.46 -0.38 7.94e-13 Inflammatory bowel disease; CRC cis rs853679 0.517 rs4713146 chr6:28111536 A/T cg03623178 chr6:28175578 NA 0.98 12.66 0.57 3.31e-30 Depression; CRC cis rs7914558 1.000 rs7081075 chr10:104929191 C/T cg04362960 chr10:104952993 NT5C2 0.59 8.71 0.43 1.46e-16 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs2303759 0.709 rs8102658 chr19:49828855 C/T cg22590775 chr19:49891494 CCDC155 0.6 7.79 0.39 8.76e-14 Multiple sclerosis; CRC trans rs2727020 0.635 rs7124266 chr11:49280857 T/G cg03929089 chr4:120376271 NA 0.66 9.07 0.45 1.07e-17 Coronary artery disease; CRC cis rs4268898 0.722 rs11691212 chr2:24404733 A/G cg02683114 chr2:24398427 C2orf84 0.35 5.68 0.3 3.01e-8 Asthma; CRC cis rs11123170 0.503 rs28679654 chr2:113967617 C/T cg12889195 chr2:113992843 PAX8;LOC440839;LOC654433 0.5 5.93 0.31 7.47e-9 Renal function-related traits (BUN); CRC cis rs875971 0.660 rs1860468 chr7:66107252 T/C cg11764359 chr7:65958608 NA -0.54 -8.35 -0.42 1.93e-15 Aortic root size; CRC cis rs1348850 0.793 rs6736390 chr2:178480314 T/C cg02961200 chr2:178257176 LOC100130691;AGPS 0.5 7.02 0.36 1.28e-11 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs523522 0.892 rs4767916 chr12:121024032 T/C cg12219531 chr12:120966889 COQ5 0.7 9.18 0.45 5.08e-18 High light scatter reticulocyte count; CRC cis rs10492096 0.947 rs11559082 chr12:6602367 C/T cg07142400 chr12:6602447 NCAPD2;MRPL51 -0.48 -5.65 -0.3 3.49e-8 Hip geometry; CRC cis rs17401966 0.809 rs12406943 chr1:10308545 T/C cg19773385 chr1:10388646 KIF1B -0.66 -10.71 -0.51 3.7e-23 Hepatocellular carcinoma; CRC cis rs920590 0.684 rs3899017 chr8:19669198 A/T cg03894339 chr8:19674705 INTS10 0.42 5.85 0.31 1.19e-8 Acute lymphoblastic leukemia (childhood); CRC cis rs7208859 0.673 rs73263785 chr17:29214808 C/T cg01831904 chr17:28903510 LRRC37B2 -0.54 -5.65 -0.3 3.39e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs12410462 1.000 rs75652886 chr1:227654485 G/T cg23173402 chr1:227635558 NA 0.71 8.01 0.4 2.03e-14 Major depressive disorder; CRC trans rs9747201 1.000 rs55638685 chr17:80107566 G/C cg07393940 chr7:158741817 NA -0.51 -7.38 -0.38 1.27e-12 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs7945705 0.902 rs11042088 chr11:8843515 T/A cg00186954 chr11:8933980 ST5;C11orf17 0.41 6.21 0.32 1.57e-9 Hemoglobin concentration; CRC cis rs2549003 1.000 rs17848418 chr5:131821188 C/T cg00255919 chr5:131827918 IRF1 0.59 11.92 0.55 1.77e-27 Asthma (sex interaction); CRC cis rs6120849 0.754 rs6120797 chr20:33606002 G/A cg24642439 chr20:33292090 TP53INP2 0.43 5.61 0.3 4.28e-8 Protein C levels; CRC cis rs6121246 0.529 rs6060195 chr20:30185638 C/T cg18721089 chr20:30220636 NA -0.52 -7.93 -0.4 3.54e-14 Mean corpuscular hemoglobin; CRC cis rs853679 0.517 rs9368550 chr6:28051803 T/A cg12172441 chr6:28176163 NA 0.6 7.2 0.37 4.23e-12 Depression; CRC cis rs4737010 0.501 rs34342524 chr8:41633857 G/A cg17182837 chr8:41585554 ANK1 0.59 8.16 0.41 7.33e-15 Lymphocyte counts;High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Reticulocyte count;Reticulocyte fraction of red cells;Mean corpuscular volume;Immature fraction of reticulocytes;Mean corpuscular hemoglobin concentration; CRC cis rs8177253 0.665 rs8177178 chr3:133463272 G/A cg11941060 chr3:133502564 NA -0.52 -8.34 -0.42 2.07e-15 Iron status biomarkers; CRC cis rs1552244 0.882 rs34706481 chr3:10004123 G/A cg10729496 chr3:10149963 C3orf24 0.53 6.62 0.34 1.42e-10 Alzheimer's disease; CRC cis rs7831492 0.564 rs6981979 chr8:41612255 C/T cg17182837 chr8:41585554 ANK1 -0.65 -11.01 -0.52 3.32e-24 Colorectal cancer; CRC cis rs11098499 0.739 rs6534130 chr4:120131339 A/T cg24375607 chr4:120327624 NA -0.46 -7.66 -0.39 2.08e-13 Corneal astigmatism; CRC cis rs4481887 0.927 rs4341391 chr1:248475720 A/G cg13385794 chr1:248469461 NA 0.38 6.65 0.34 1.19e-10 Common traits (Other); CRC cis rs7605827 0.897 rs6734288 chr2:15526222 T/G cg19274914 chr2:15703543 NA 0.39 5.9 0.31 8.92e-9 Educational attainment (years of education); CRC cis rs2075371 1.000 rs2505 chr7:133979552 C/T cg20476274 chr7:133979776 SLC35B4 0.81 14.73 0.63 4.56e-38 Mean platelet volume; CRC cis rs10504229 0.679 rs17193048 chr8:58055392 G/A cg20607798 chr8:58055168 NA 0.52 5.94 0.31 7.24e-9 Developmental language disorder (linguistic errors); CRC cis rs5997397 0.934 rs6005863 chr22:29156448 A/G cg15103426 chr22:29168792 CCDC117 0.41 6.14 0.32 2.37e-9 Red cell distribution width; CRC cis rs10911232 0.507 rs4652765 chr1:182994147 C/T ch.1.3577855R chr1:183094577 LAMC1 0.86 15.15 0.64 1.1e-39 Hypertriglyceridemia; CRC cis rs4713118 0.527 rs4713151 chr6:28136356 G/A cg12963246 chr6:28129442 ZNF389 0.49 5.7 0.3 2.71e-8 Parkinson's disease; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg00308216 chr16:66440692 NA 0.44 5.99 0.31 5.62e-9 Response to antipsychotic treatment; CRC trans rs12599106 0.648 rs12447240 chr16:34928236 C/T cg26668828 chr6:292823 DUSP22 0.68 10.25 0.49 1.44e-21 Menopause (age at onset); CRC cis rs2243480 1.000 rs35396113 chr7:65495461 C/T cg25985355 chr7:65971099 NA -0.5 -5.71 -0.3 2.56e-8 Diabetic kidney disease; CRC cis rs1552244 0.882 rs17050660 chr3:10001772 A/G cg00166722 chr3:10149974 C3orf24 -0.62 -8.33 -0.42 2.25e-15 Alzheimer's disease; CRC cis rs172166 0.515 rs2622320 chr6:28115336 T/A cg03623178 chr6:28175578 NA 0.66 10.06 0.49 6.13e-21 Cardiac Troponin-T levels; CRC cis rs10788264 0.544 rs10788269 chr10:124022870 A/G cg09507567 chr10:124027408 NA 0.35 7.52 0.38 5.11e-13 Total body bone mineral density; CRC cis rs1003719 0.715 rs2835659 chr21:38567902 C/T cg10648535 chr21:38446584 PIGP;TTC3 -0.45 -6.34 -0.33 7.37e-10 Eye color traits; CRC cis rs2735413 0.918 rs12918409 chr16:78082681 G/A cg04733911 chr16:78082701 NA -0.45 -7.41 -0.38 1.11e-12 Systolic blood pressure (alcohol consumption interaction); CRC trans rs916888 0.821 rs199504 chr17:44861003 C/T cg22968622 chr17:43663579 NA -1.2 -15.54 -0.65 3.09e-41 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs4243830 0.850 rs10864612 chr1:6593830 C/G cg22792644 chr1:6614718 TAS1R1;NOL9 -0.79 -9.8 -0.48 4.6e-20 Body mass index; CRC trans rs8073060 0.586 rs35542792 chr17:33903886 A/G cg19694781 chr19:47549865 TMEM160 1.0 13.88 0.61 8.21e-35 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; CRC cis rs10771431 0.597 rs3759274 chr12:9353875 T/C cg22349387 chr12:9600060 DDX12 -0.36 -5.65 -0.3 3.41e-8 Breast size; CRC cis rs6665290 0.904 rs6664955 chr1:227183434 T/C cg10327440 chr1:227177885 CDC42BPA -1.04 -22.88 -0.78 5.34e-70 Myeloid white cell count; CRC trans rs12699921 0.632 rs1524776 chr7:17872093 C/A cg15753394 chr6:17282781 RBM24 -0.36 -6.13 -0.32 2.5e-9 Fibrinogen levels; CRC cis rs7843479 0.544 rs4872110 chr8:21784989 A/G cg17168535 chr8:21777572 XPO7 0.66 10.95 0.52 5.54e-24 Mean corpuscular volume; CRC cis rs6460942 0.818 rs116613169 chr7:12234669 T/C cg06484146 chr7:12443880 VWDE -0.67 -6.55 -0.34 2.22e-10 Coronary artery disease; CRC cis rs12134245 0.776 rs12137878 chr1:91973210 G/T cg25838465 chr1:92012736 NA -0.68 -12.44 -0.57 2.26e-29 Breast cancer; CRC cis rs1799949 1.000 rs12936816 chr17:41301709 C/T cg25072359 chr17:41440525 NA 0.46 6.97 0.36 1.79e-11 Menopause (age at onset); CRC cis rs2000999 0.778 rs12445401 chr16:72148419 A/G cg01557791 chr16:72042693 DHODH -0.51 -5.7 -0.3 2.68e-8 Total cholesterol levels;Cholesterol, total;Blood protein levels;LDL cholesterol levels;Haptoglobin levels;LDL cholesterol; CRC cis rs11122272 0.735 rs2486733 chr1:231531465 C/T cg06096015 chr1:231504339 EGLN1 0.41 6.19 0.32 1.8e-9 Hemoglobin concentration; CRC cis rs62229266 0.804 rs11088331 chr21:37421872 T/C cg12218747 chr21:37451666 NA -0.45 -7.75 -0.39 1.18e-13 Mitral valve prolapse; CRC cis rs1862618 0.671 rs2591961 chr5:56238597 A/G cg03609598 chr5:56110824 MAP3K1 0.59 8.32 0.42 2.35e-15 Initial pursuit acceleration; CRC cis rs11864453 0.713 rs12708926 chr16:72126063 T/C cg23815491 chr16:72088622 HP 0.5 7.6 0.39 3.09e-13 Fibrinogen levels; CRC cis rs912057 0.632 rs1294429 chr6:6744652 G/A cg06612196 chr6:6737390 NA 0.54 8.59 0.43 3.49e-16 Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction); CRC cis rs12477438 0.520 rs4851188 chr2:99745898 G/A cg14399236 chr2:99771627 LIPT1;TSGA10 0.73 12.36 0.56 4.4e-29 Chronic sinus infection; CRC trans rs17685 0.753 rs1637037 chr7:75692927 C/T cg19862616 chr7:65841803 NCRNA00174 0.99 18.7 0.72 1.09e-53 Coffee consumption;Coffee consumption (cups per day); CRC cis rs798554 0.680 rs1713912 chr7:2895784 C/A cg19346786 chr7:2764209 NA -0.34 -5.92 -0.31 8.17e-9 Height; CRC cis rs6499255 0.951 rs78772829 chr16:69607098 G/A cg04110750 chr16:69646130 NFAT5 -0.53 -7.24 -0.37 3.13e-12 IgE levels; CRC trans rs2665103 0.632 rs3902959 chr15:82544927 C/T cg04831495 chr15:85060580 GOLGA6L5 -0.39 -6.11 -0.32 2.76e-9 Intelligence (multi-trait analysis); CRC cis rs2857891 0.697 rs1004754 chr11:6946248 T/C cg26870460 chr11:6947759 ZNF215 0.58 6.06 0.32 3.73e-9 Response to cytadine analogues (cytosine arabinoside); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg16975973 chr12:77459865 E2F7 0.49 7.03 0.36 1.18e-11 Response to antipsychotic treatment; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg08866780 chr21:27543523 APP 0.42 6.48 0.34 3.34e-10 Liver disease severity in Alagille syndrome; CRC trans rs916888 0.610 rs199452 chr17:44801340 C/T cg10053473 chr17:62856997 LRRC37A3 -0.59 -8.23 -0.41 4.29e-15 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs73195822 0.614 rs17190144 chr12:111214767 A/G cg12870014 chr12:110450643 ANKRD13A 0.67 7.46 0.38 8e-13 Itch intensity from mosquito bite; CRC cis rs10751667 0.643 rs10794350 chr11:946070 A/G cg06064525 chr11:970664 AP2A2 -0.34 -6.91 -0.36 2.58e-11 Alzheimer's disease (late onset); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg04048411 chr12:94541943 PLXNC1 0.39 6.76 0.35 6.38e-11 Liver disease severity in Alagille syndrome; CRC trans rs1455244 0.700 rs7229302 chr18:11508904 G/T cg27561072 chr1:19812431 CAPZB 0.42 6.6 0.34 1.64e-10 Schizophrenia; CRC cis rs13315871 1.000 rs11719957 chr3:58415031 A/G cg20936604 chr3:58311152 NA -0.76 -7.15 -0.37 5.74e-12 Cholesterol, total; CRC cis rs6691722 0.503 rs6667695 chr1:24707669 G/A cg18323236 chr1:24743029 NIPAL3 0.39 5.68 0.3 2.96e-8 Response to interferon beta in multiple sclerosis; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg16755220 chr16:12070685 RUNDC2A 0.36 6.21 0.32 1.6e-9 Liver disease severity in Alagille syndrome; CRC trans rs2048656 0.523 rs1976673 chr8:9679780 T/A cg06636001 chr8:8085503 FLJ10661 0.51 7.01 0.36 1.35e-11 Schizophrenia; CRC cis rs7586879 0.828 rs10195271 chr2:25108650 A/C cg04586622 chr2:25135609 ADCY3 0.57 9.81 0.48 4.26e-20 Body mass index; CRC cis rs9858542 1.000 rs6770670 chr3:49686682 T/C cg07274523 chr3:49395745 GPX1 0.46 6.02 0.31 4.74e-9 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs7584330 0.554 rs80151891 chr2:238398826 G/T cg08992911 chr2:238395768 MLPH 0.6 6.07 0.32 3.56e-9 Prostate cancer; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg01555791 chr17:1012288 ABR 0.52 6.68 0.35 1e-10 Thyroid stimulating hormone; CRC cis rs28735056 0.904 rs62103174 chr18:77621048 A/G cg12845895 chr18:77676008 PQLC1 0.41 5.85 0.31 1.21e-8 Schizophrenia; CRC cis rs597539 0.652 rs602364 chr11:68662167 C/T cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.9 15.49 0.65 5.06e-41 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs6912958 0.582 rs242285 chr6:88070743 G/A cg12350822 chr6:88032061 C6orf162;GJB7 0.5 10.03 0.48 7.78e-21 Monocyte percentage of white cells; CRC cis rs9902453 0.765 rs2617883 chr17:28120488 G/A cg26525008 chr17:28256777 EFCAB5;SSH2 -0.73 -12.23 -0.56 1.28e-28 Coffee consumption (cups per day); CRC cis rs1862618 0.671 rs832531 chr5:56228401 A/G cg12311346 chr5:56204834 C5orf35 -0.66 -9.96 -0.48 1.39e-20 Initial pursuit acceleration; CRC cis rs7312933 0.501 rs3810793 chr12:42729407 C/T cg19980929 chr12:42632907 YAF2 0.41 6.16 0.32 2.17e-9 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CRC cis rs10504229 0.683 rs6980540 chr8:58127022 A/G cg24829409 chr8:58192753 C8orf71 -0.54 -7.88 -0.4 4.9e-14 Developmental language disorder (linguistic errors); CRC cis rs7811142 0.887 rs4074838 chr7:100032665 G/A cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.17 17.44 0.69 1.04e-48 Platelet count; CRC cis rs1448094 0.817 rs61929421 chr12:86342330 T/C cg00310523 chr12:86230176 RASSF9 0.43 7.21 0.37 3.87e-12 Major depressive disorder; CRC cis rs1983170 0.736 rs4484968 chr1:92012005 C/A cg02896835 chr1:92012615 NA 0.54 6.65 0.34 1.25e-10 Eosinophil percentage of white cells; CRC cis rs2629540 0.924 rs2629541 chr10:126425866 G/A cg08799069 chr10:126477246 METTL10 0.63 7.9 0.4 4.32e-14 Cocaine dependence; CRC cis rs58688157 0.705 rs7122021 chr11:595810 A/G cg07212818 chr11:638076 DRD4 -0.45 -5.81 -0.31 1.48e-8 Systemic lupus erythematosus; CRC trans rs7819412 0.668 rs2409714 chr8:11010118 A/G cg06636001 chr8:8085503 FLJ10661 -0.43 -6.3 -0.33 9.42e-10 Triglycerides; CRC cis rs7772486 0.764 rs7745696 chr6:146162829 T/C cg05347473 chr6:146136440 FBXO30 0.37 5.79 0.3 1.67e-8 Lobe attachment (rater-scored or self-reported); CRC cis rs748404 0.723 rs565658 chr15:43556307 C/T cg02155558 chr15:43621948 ADAL;LCMT2 0.42 6.29 0.33 9.83e-10 Lung cancer; CRC trans rs9395865 0.501 rs2067833 chr6:53330356 A/G cg00089314 chr5:135169284 LOC153328 -0.34 -5.96 -0.31 6.36e-9 Electroencephalographic traits in alcoholism; CRC cis rs1005277 0.540 rs11011351 chr10:38030525 A/G cg25427524 chr10:38739819 LOC399744 -0.73 -12.72 -0.57 1.94e-30 Extrinsic epigenetic age acceleration; CRC cis rs2692947 0.644 rs1168974 chr2:96814928 G/A cg23100626 chr2:96804247 ASTL 0.3 7.98 0.4 2.47e-14 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; CRC cis rs2806561 0.734 rs2806564 chr1:23506685 T/C cg12483005 chr1:23474871 LUZP1 0.52 7.53 0.38 4.82e-13 Height; CRC cis rs10791323 0.569 rs10750552 chr11:133740141 A/C cg06766960 chr11:133703094 NA 0.35 6.33 0.33 8.24e-10 Childhood ear infection; CRC cis rs2050392 0.624 rs303447 chr10:30728464 T/C cg18806716 chr10:30721971 MAP3K8 -0.71 -10.23 -0.49 1.62e-21 Inflammatory bowel disease; CRC cis rs8078723 0.738 rs4065321 chr17:38143548 C/T cg17344932 chr17:38183730 MED24;SNORD124 0.48 7.9 0.4 4.28e-14 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); CRC cis rs4253772 0.550 rs9615913 chr22:46668515 A/T cg03482458 chr22:46692211 CN5H6.4;GTSE1 -0.55 -7.57 -0.39 3.85e-13 LDL cholesterol;Cholesterol, total; CRC cis rs1448094 0.791 rs61929395 chr12:86331584 A/T cg18827107 chr12:86230957 RASSF9 -0.42 -6.64 -0.34 1.32e-10 Major depressive disorder; CRC trans rs1455244 0.700 rs7229302 chr18:11508904 G/T cg22792432 chr18:18691067 ROCK1 0.4 6.18 0.32 1.93e-9 Schizophrenia; CRC cis rs2731664 0.792 rs337374 chr5:176890416 A/G cg23176889 chr5:176863531 GRK6 0.75 15.96 0.66 7.4e-43 Intelligence (multi-trait analysis); CRC cis rs55788414 0.932 rs12716908 chr16:81186245 T/C cg06400318 chr16:81190750 PKD1L2 -0.61 -7.12 -0.37 6.84e-12 Left ventricular obstructive tract defect (maternal effect); CRC cis rs4689388 0.926 rs9998835 chr4:6293237 C/G cg25554036 chr4:6271136 WFS1 0.53 8.69 0.43 1.74e-16 Type 2 diabetes and other traits;Type 2 diabetes; CRC cis rs7811142 1.000 rs7783159 chr7:100017454 C/T cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.18 16.51 0.67 4.95e-45 Platelet count; CRC cis rs4925325 1.000 rs4925325 chr20:60514224 G/A cg13770153 chr20:60521292 NA 0.99 17.22 0.69 7.74e-48 Obesity-related traits; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg10435706 chr6:150039699 LATS1 0.47 6.22 0.32 1.47e-9 Thyroid stimulating hormone; CRC cis rs6681460 0.932 rs2044399 chr1:67054080 T/C cg02459107 chr1:67143332 SGIP1 0.44 7.45 0.38 8.42e-13 Presence of antiphospholipid antibodies; CRC trans rs11654801 0.812 rs62056764 chr17:20875145 A/G cg23759823 chr7:139672531 TBXAS1 -0.38 -6.0 -0.31 5.17e-9 Mosquito bite size; CRC cis rs11645898 0.872 rs72787070 chr16:72151101 T/C cg14768367 chr16:72042858 DHODH -0.57 -6.4 -0.33 5.47e-10 Blood protein levels; CRC cis rs11190604 0.697 rs4559619 chr10:102199884 C/T cg07080220 chr10:102295463 HIF1AN -0.49 -6.3 -0.33 9.34e-10 Palmitoleic acid (16:1n-7) levels; CRC cis rs4731207 0.596 rs7810299 chr7:124645104 A/G cg23710748 chr7:124431027 NA -0.39 -6.25 -0.33 1.24e-9 Cutaneous malignant melanoma; CRC cis rs9649213 0.593 rs7787858 chr7:98009914 T/C cg00277769 chr7:97922759 BAIAP2L1 -0.59 -10.17 -0.49 2.65e-21 Prostate cancer (SNP x SNP interaction); CRC cis rs79387448 0.745 rs75644281 chr2:103151316 A/T cg09003973 chr2:102972529 NA 0.73 8.14 0.41 8.53e-15 Gut microbiota (bacterial taxa); CRC cis rs10504229 0.679 rs11783557 chr8:58030644 A/G cg02725872 chr8:58115012 NA -0.37 -6.55 -0.34 2.16e-10 Developmental language disorder (linguistic errors); CRC cis rs34375054 0.558 rs12578774 chr12:125681761 A/G cg25124228 chr12:125621409 AACS 0.51 7.09 0.36 8.43e-12 Post bronchodilator FEV1/FVC ratio; CRC trans rs2303319 0.504 rs62187658 chr2:162488095 A/C cg25193742 chr10:104614220 C10orf32 -0.78 -6.16 -0.32 2.17e-9 Cognitive function; CRC cis rs2996428 0.561 rs12134919 chr1:3744641 G/A cg22529645 chr1:3704559 LRRC47 0.42 5.76 0.3 1.88e-8 Red cell distribution width; CRC cis rs6089584 0.606 rs2144674 chr20:60576579 G/A cg06108461 chr20:60628389 TAF4 -0.66 -11.33 -0.53 2.46e-25 Body mass index; CRC cis rs9911578 1.000 rs11079365 chr17:56945430 T/C cg05425664 chr17:57184151 TRIM37 -0.49 -7.77 -0.39 9.89e-14 Intelligence (multi-trait analysis); CRC cis rs2204008 0.777 rs2049130 chr12:38444837 G/A cg13010199 chr12:38710504 ALG10B 0.45 6.02 0.31 4.73e-9 Bladder cancer; CRC trans rs55675132 0.548 rs12120464 chr1:115377691 C/T cg25493687 chr8:27288214 PTK2B 0.49 6.0 0.31 5.23e-9 Schizophrenia; CRC cis rs7811142 1.000 rs67315960 chr7:100015124 A/G cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.19 17.8 0.7 4.05e-50 Platelet count; CRC cis rs1552244 0.554 rs17050704 chr3:10045734 T/C cg18598329 chr3:10140678 FANCD2;C3orf24 -0.53 -7.53 -0.38 4.84e-13 Alzheimer's disease; CRC cis rs2290405 0.593 rs12499663 chr4:888170 G/A cg09237302 chr4:906077 GAK -0.33 -5.89 -0.31 9.39e-9 Systemic sclerosis; CRC cis rs782590 0.902 rs782595 chr2:55845596 C/G cg18811423 chr2:55921094 PNPT1 0.8 14.68 0.63 7.06e-38 Metabolic syndrome; CRC cis rs1865760 0.786 rs2164487 chr6:25950800 A/C cg17691542 chr6:26056736 HIST1H1C 0.55 8.29 0.42 2.87e-15 Height; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg22227586 chr10:88854610 FAM35A;GLUD1 0.4 6.25 0.33 1.3e-9 Intelligence (multi-trait analysis); CRC cis rs7737355 0.947 rs42264 chr5:130810028 T/G cg06307176 chr5:131281290 NA 0.43 6.36 0.33 6.6e-10 Life satisfaction; CRC cis rs9549367 0.713 rs4907599 chr13:113861441 C/T cg24300038 chr13:113819356 PROZ 0.51 6.79 0.35 5.17e-11 Platelet distribution width; CRC cis rs3858526 0.584 rs10769270 chr11:5860563 T/C cg26762873 chr11:5879799 OR52E8 -0.48 -7.2 -0.37 4.19e-12 DNA methylation (variation); CRC cis rs1448094 0.512 rs11832992 chr12:86240790 T/C cg25456477 chr12:86230367 RASSF9 0.32 5.64 0.3 3.58e-8 Major depressive disorder; CRC cis rs270601 0.837 rs367805 chr5:131701279 T/C cg24060327 chr5:131705240 SLC22A5 -0.52 -7.8 -0.4 8.03e-14 Acylcarnitine levels; CRC cis rs1552244 1.000 rs17032277 chr3:10077023 T/C cg08888203 chr3:10149979 C3orf24 0.73 10.08 0.49 5.45e-21 Alzheimer's disease; CRC cis rs1552244 0.938 rs7647987 chr3:10140696 A/G cg18598329 chr3:10140678 FANCD2;C3orf24 -0.9 -13.24 -0.59 2.25e-32 Alzheimer's disease; CRC cis rs17601876 0.814 rs7181429 chr15:51559496 G/A cg19946085 chr15:51559439 CYP19A1 -0.35 -7.06 -0.36 9.77e-12 Estrone/androstenedione ratio in resected early stage-receptor positive breast cancer; CRC cis rs951366 0.764 rs708725 chr1:205744138 G/T cg07167872 chr1:205819463 PM20D1 0.78 12.17 0.56 2.2e-28 Menarche (age at onset); CRC trans rs116095464 0.614 rs4371799 chr5:268192 C/A cg00938859 chr5:1591904 SDHAP3 0.68 7.52 0.38 5.16e-13 Breast cancer; CRC cis rs10242455 0.702 rs73713580 chr7:99241610 C/T cg18809830 chr7:99032528 PTCD1 -1.04 -7.34 -0.38 1.68e-12 Blood metabolite levels; CRC cis rs6424115 1.000 rs12116511 chr1:24162662 A/G cg15997130 chr1:24165203 NA -0.75 -11.69 -0.54 1.2e-26 Immature fraction of reticulocytes; CRC cis rs919433 0.680 rs788018 chr2:198265526 A/G cg10820045 chr2:198174542 NA 0.39 6.58 0.34 1.86e-10 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC cis rs2153535 0.580 rs1115078 chr6:8449638 G/A cg21535247 chr6:8435926 SLC35B3 0.5 7.5 0.38 6.06e-13 Motion sickness; CRC cis rs116095464 0.558 rs57335027 chr5:262907 A/G cg22496380 chr5:211416 CCDC127 -0.91 -10.46 -0.5 2.65e-22 Breast cancer; CRC cis rs6570726 0.791 rs9322029 chr6:145906683 A/G cg13319975 chr6:146136371 FBXO30 -0.42 -6.28 -0.33 1.04e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs2976388 1.000 rs10216533 chr8:143763690 G/A cg22687807 chr8:143858763 LYNX1 -0.38 -6.57 -0.34 1.98e-10 Urinary tract infection frequency; CRC cis rs6088580 0.634 rs6088471 chr20:32932643 C/A cg08999081 chr20:33150536 PIGU -0.64 -11.93 -0.55 1.69e-27 Glomerular filtration rate (creatinine); CRC cis rs6714710 0.580 rs11692470 chr2:98520564 T/C cg26665480 chr2:98280029 ACTR1B 0.54 7.49 0.38 6.23e-13 Posterior cortical atrophy and Alzheimer's disease; CRC cis rs4722166 0.695 rs7808122 chr7:22798080 A/G cg05472934 chr7:22766657 IL6 0.66 10.86 0.51 1.11e-23 Lung cancer; CRC cis rs9399135 0.967 rs9376077 chr6:135299713 C/G cg22676075 chr6:135203613 NA 0.42 6.38 0.33 6.18e-10 Red blood cell count; CRC cis rs11098499 0.954 rs10024844 chr4:120311528 A/G cg24375607 chr4:120327624 NA 0.51 7.86 0.4 5.5e-14 Corneal astigmatism; CRC trans rs853679 0.769 rs7752608 chr6:28301195 A/G cg06606381 chr12:133084897 FBRSL1 -1.13 -9.75 -0.47 6.87e-20 Depression; CRC cis rs911555 0.755 rs2273702 chr14:103918182 C/G cg12935359 chr14:103987150 CKB 0.54 8.73 0.43 1.33e-16 Intelligence (multi-trait analysis); CRC cis rs1697139 0.935 rs1627990 chr5:66513326 C/T cg11553311 chr5:66541588 NA 0.47 8.1 0.41 1.06e-14 Breast cancer; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg01398432 chr7:102389392 FAM185A 0.44 6.32 0.33 8.52e-10 Intelligence (multi-trait analysis); CRC cis rs10992471 0.756 rs2516568 chr9:95187380 A/T cg13798575 chr9:95087839 CENPP;NOL8 -0.48 -6.94 -0.36 2.04e-11 Visceral adipose tissue/subcutaneous adipose tissue ratio; CRC cis rs28374715 0.528 rs7178360 chr15:41631175 T/A cg18705301 chr15:41695430 NDUFAF1 -1.09 -19.04 -0.72 5.24e-55 Ulcerative colitis; CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg15309264 chr2:58274034 VRK2 -0.49 -6.12 -0.32 2.64e-9 Diisocyanate-induced asthma; CRC cis rs28386778 0.734 rs7210724 chr17:61799198 T/C cg11494091 chr17:61959527 GH2 0.61 10.2 0.49 2.05e-21 Prudent dietary pattern; CRC cis rs9403521 0.673 rs7772565 chr6:143993070 A/T cg18240653 chr6:144019428 PHACTR2 0.44 5.83 0.31 1.35e-8 Obesity-related traits; CRC cis rs17345786 0.861 rs74768235 chr3:101142821 T/C cg11279151 chr3:101281821 RG9MTD1 -0.66 -8.13 -0.41 8.89e-15 Colonoscopy-negative controls vs population controls; CRC cis rs12541335 0.639 rs7003478 chr8:22201123 A/G cg18135555 chr8:22132992 PIWIL2 0.41 7.92 0.4 3.73e-14 Hypertriglyceridemia; CRC trans rs9291683 0.546 rs13110307 chr4:10044364 T/C cg26043149 chr18:55253948 FECH 0.51 7.63 0.39 2.62e-13 Bone mineral density; CRC cis rs868943 0.743 rs10457303 chr6:116413841 C/T cg15226275 chr6:116381976 FRK 0.3 7.05 0.36 1.04e-11 Total cholesterol levels; CRC cis rs11249608 0.548 rs7707587 chr5:178462590 G/C cg01312482 chr5:178451176 ZNF879 -0.34 -5.68 -0.3 2.89e-8 Pubertal anthropometrics; CRC cis rs6426558 0.537 rs2813950 chr1:227426072 A/G cg10327440 chr1:227177885 CDC42BPA -0.4 -6.03 -0.32 4.32e-9 Neutrophil percentage of white cells; CRC cis rs12541635 0.934 rs2115703 chr8:107045935 C/G cg10147462 chr8:107024639 NA 0.45 7.56 0.38 3.98e-13 Age of smoking initiation; CRC cis rs1832871 0.655 rs4273715 chr6:158722847 T/C cg07165851 chr6:158734300 TULP4 0.62 7.81 0.4 7.93e-14 Height; CRC cis rs11098499 0.954 rs11729521 chr4:120416788 T/C cg09307838 chr4:120376055 NA 0.72 11.14 0.52 1.1e-24 Corneal astigmatism; CRC cis rs977987 0.736 rs11865296 chr16:75473693 C/T cg03315344 chr16:75512273 CHST6 0.55 9.31 0.46 1.88e-18 Dupuytren's disease; CRC cis rs546131 1.000 rs546131 chr11:34851760 G/C cg11058730 chr11:34937778 PDHX;APIP 0.47 6.86 0.35 3.32e-11 Lung disease severity in cystic fibrosis; CRC trans rs1814175 0.645 rs1851845 chr11:49982396 C/T cg11707556 chr5:10655725 ANKRD33B -0.52 -10.05 -0.48 6.61e-21 Height; CRC cis rs798554 0.757 rs1182177 chr7:2874540 C/T cg19717773 chr7:2847554 GNA12 -0.48 -6.84 -0.35 3.85e-11 Height; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg00603428 chr6:122721289 HSF2 0.47 6.18 0.32 1.84e-9 Anxiety disorder; CRC cis rs9297145 0.761 rs62473015 chr7:98763301 G/A cg05967295 chr7:98741636 SMURF1 1.14 17.8 0.7 3.94e-50 Crohn's disease;Inflammatory bowel disease;Ulcerative colitis; CRC cis rs1448094 0.967 rs2044617 chr12:86324089 T/C cg19622623 chr12:86230825 RASSF9 -0.35 -5.69 -0.3 2.8e-8 Major depressive disorder; CRC cis rs1670533 1.000 rs11725984 chr4:1087338 C/T cg27284194 chr4:1044797 NA 0.5 6.33 0.33 7.9e-10 Recombination rate (females); CRC cis rs7927771 1.000 rs9909 chr11:47799775 C/G cg20307385 chr11:47447363 PSMC3 -0.5 -6.58 -0.34 1.83e-10 Subjective well-being; CRC cis rs11122272 0.701 rs1009227 chr1:231480507 A/G cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.55 -8.2 -0.41 5.35e-15 Hemoglobin concentration; CRC cis rs11628318 0.853 rs4906226 chr14:103027359 C/T cg02094049 chr14:103021097 NA -0.54 -6.94 -0.36 2.16e-11 Platelet count; CRC cis rs652260 1.000 rs652260 chr19:7900562 C/T cg26014689 chr19:7917955 EVI5L -0.54 -8.83 -0.44 6.37e-17 Menarche (age at onset); CRC cis rs7119 0.717 rs11634174 chr15:77811232 A/T cg10437265 chr15:77819839 NA 0.66 12.4 0.56 3.06e-29 Type 2 diabetes; CRC cis rs7927771 1.000 rs10838748 chr11:47716381 T/G cg05585544 chr11:47624801 NA -0.61 -10.91 -0.52 7.39e-24 Subjective well-being; CRC cis rs1577917 0.727 rs2758840 chr6:86304625 A/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.67 -8.79 -0.44 8.78e-17 Response to antipsychotic treatment; CRC cis rs2050392 0.928 rs6481677 chr10:30701816 A/G cg25182066 chr10:30743637 MAP3K8 -0.37 -5.62 -0.3 4.07e-8 Inflammatory bowel disease; CRC cis rs11105298 0.891 rs10777162 chr12:89830523 A/G cg00757033 chr12:89920650 WDR51B 0.34 5.84 0.31 1.28e-8 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg07908229 chr1:182353640 GLUL -0.39 -6.16 -0.32 2.17e-9 Liver disease severity in Alagille syndrome; CRC trans rs11098499 0.863 rs59732491 chr4:120489588 G/C cg25214090 chr10:38739885 LOC399744 0.67 10.24 0.49 1.58e-21 Corneal astigmatism; CRC cis rs6912958 0.781 rs6454631 chr6:88225863 G/A cg12350822 chr6:88032061 C6orf162;GJB7 -0.33 -6.14 -0.32 2.32e-9 Monocyte percentage of white cells; CRC cis rs7772486 0.790 rs2814880 chr6:146208937 T/G cg13319975 chr6:146136371 FBXO30 -0.4 -6.14 -0.32 2.32e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs2243480 1.000 rs6974723 chr7:65637939 C/T cg25985355 chr7:65971099 NA 0.52 6.01 0.31 4.92e-9 Diabetic kidney disease; CRC cis rs17065868 0.764 rs9595130 chr13:45043439 G/A cg10246903 chr13:45222710 NA 0.55 5.85 0.31 1.18e-8 Antineutrophil cytoplasmic antibody-associated vasculitis; CRC cis rs11997175 0.545 rs66584807 chr8:33667609 A/G cg04338863 chr8:33670619 NA 0.4 6.39 0.33 5.7e-10 Body mass index; CRC trans rs61931739 0.534 rs1211286 chr12:34135581 T/C cg26384229 chr12:38710491 ALG10B 0.5 7.02 0.36 1.3e-11 Morning vs. evening chronotype; CRC cis rs7113874 0.524 rs10769922 chr11:8621752 G/A cg17679104 chr11:8615758 STK33 0.34 5.8 0.3 1.59e-8 Body mass index in physically active individuals;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs713587 0.713 rs12618252 chr2:25207950 G/A cg04586622 chr2:25135609 ADCY3 0.36 6.09 0.32 3.16e-9 Body mass index in non-asthmatics; CRC cis rs939658 0.805 rs59104559 chr15:79438784 A/G cg17916960 chr15:79447300 NA -0.43 -7.03 -0.36 1.18e-11 Refractive error; CRC cis rs9325144 0.671 rs7306605 chr12:38730471 C/T cg13010199 chr12:38710504 ALG10B 0.43 6.26 0.33 1.22e-9 Morning vs. evening chronotype; CRC cis rs13191362 0.935 rs34035978 chr6:163165336 G/C cg23758597 chr6:163146217 PARK2 -0.6 -6.71 -0.35 8.55e-11 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs7937682 0.855 rs11213985 chr11:111581521 C/A cg09085632 chr11:111637200 PPP2R1B -1.01 -20.41 -0.75 2.08e-60 Primary sclerosing cholangitis; CRC cis rs933688 1.000 rs2839728 chr5:90727412 G/A cg26981201 chr5:90679533 LOC100129716;ARRDC3 1.01 18.2 0.71 1.06e-51 Smoking behavior; CRC cis rs4268898 0.662 rs17789375 chr2:24502554 G/T cg06627628 chr2:24431161 ITSN2 -0.75 -10.28 -0.49 1.08e-21 Asthma; CRC cis rs933688 1.000 rs2367353 chr5:90686568 G/C cg02339078 chr5:90679543 LOC100129716;ARRDC3 0.9 15.28 0.64 3.35e-40 Smoking behavior; CRC cis rs6570726 0.846 rs870491 chr6:145933390 T/G cg23711669 chr6:146136114 FBXO30 0.65 10.71 0.51 3.64e-23 Lobe attachment (rater-scored or self-reported); CRC cis rs7927771 0.770 rs11039203 chr11:47384597 A/G cg05585544 chr11:47624801 NA -0.5 -8.86 -0.44 5e-17 Subjective well-being; CRC cis rs9341808 0.718 rs35447745 chr6:80816748 T/C cg08355045 chr6:80787529 NA 0.43 6.88 0.35 2.95e-11 Sitting height ratio; CRC cis rs911555 0.723 rs56227024 chr14:103861706 A/G cg07514618 chr14:103979422 NA 0.31 5.84 0.31 1.22e-8 Intelligence (multi-trait analysis); CRC cis rs2249694 0.960 rs8192776 chr10:135348187 T/C cg16964102 chr10:135390573 NA -0.42 -6.99 -0.36 1.58e-11 Obesity-related traits; CRC cis rs875971 0.830 rs778715 chr7:65849209 C/T cg11764359 chr7:65958608 NA 0.59 9.08 0.45 1.06e-17 Aortic root size; CRC cis rs909002 0.772 rs10914452 chr1:32074575 G/A cg01639898 chr1:32083012 HCRTR1 0.3 6.1 0.32 3e-9 Intelligence (multi-trait analysis); CRC cis rs1975974 0.935 rs67979358 chr17:21723834 G/C cg18423549 chr17:21743878 NA -0.65 -9.08 -0.45 1.01e-17 Psoriasis; CRC cis rs1790761 0.967 rs3741168 chr11:67235351 A/G cg17375396 chr11:67202808 RPS6KB2 0.33 5.65 0.3 3.43e-8 Mean corpuscular volume; CRC trans rs7937682 0.883 rs1784775 chr11:111472460 T/C cg18187862 chr3:45730750 SACM1L 0.46 6.56 0.34 2.15e-10 Primary sclerosing cholangitis; CRC cis rs1971762 0.602 rs4759283 chr12:54079243 C/T cg06632207 chr12:54070931 ATP5G2 0.42 7.15 0.37 5.74e-12 Height; CRC cis rs12497850 0.931 rs7430198 chr3:48988760 T/C cg20833759 chr3:49053208 WDR6;DALRD3 0.53 9.29 0.46 2.18e-18 Parkinson's disease; CRC cis rs7727544 0.836 rs10463892 chr5:131598705 T/C cg09877947 chr5:131593287 PDLIM4 0.36 6.79 0.35 5.31e-11 Blood metabolite levels; CRC cis rs12580194 0.593 rs59676560 chr12:55745425 T/C cg23425280 chr12:56401806 NA 0.44 5.61 0.3 4.19e-8 Cancer; CRC cis rs10832963 0.924 rs10832950 chr11:18635815 A/G cg09201001 chr11:18656081 SPTY2D1 0.79 12.41 0.56 2.81e-29 Breast cancer; CRC cis rs2019137 0.560 rs11123172 chr2:113984303 C/T cg02675527 chr2:114030824 PAX8;LOC440839 0.42 6.33 0.33 8.17e-10 Lymphocyte counts; CRC cis rs11123170 0.542 rs11123169 chr2:113967075 C/T cg11763394 chr2:113992921 PAX8;LOC440839;LOC654433 -0.46 -6.35 -0.33 7.19e-10 Renal function-related traits (BUN); CRC cis rs763121 0.853 rs2064088 chr22:39053382 A/G cg06022373 chr22:39101656 GTPBP1 0.78 12.35 0.56 4.64e-29 Menopause (age at onset); CRC cis rs4757319 0.515 rs4313573 chr11:15330598 A/G cg03245590 chr11:15329459 NA 0.53 9.49 0.46 5.04e-19 Breast cancer; CRC cis rs16975963 0.644 rs11083430 chr19:38139488 A/G cg15135657 chr19:38346511 NA -0.47 -6.4 -0.33 5.2400000000000005e-10 Longevity; CRC cis rs12612619 0.724 rs7355650 chr2:27245475 T/C cg00617064 chr2:27272375 NA 0.38 6.16 0.32 2.13e-9 Venous thromboembolism adjusted for sickle cell variant rs77121243-T; CRC cis rs7659604 1.000 rs7659943 chr4:122665560 C/T cg19748678 chr4:122722346 EXOSC9 0.56 8.81 0.44 7.35e-17 Type 2 diabetes; CRC cis rs250677 0.687 rs3095947 chr5:148436728 T/C cg23229984 chr5:148520753 ABLIM3 0.48 6.59 0.34 1.79e-10 Breast cancer; CRC cis rs10504229 0.683 rs6980540 chr8:58127022 A/G cg02725872 chr8:58115012 NA -0.65 -11.61 -0.54 2.34e-26 Developmental language disorder (linguistic errors); CRC cis rs10540 0.730 rs61876338 chr11:493730 A/G cg03352830 chr11:487213 PTDSS2 0.67 7.7 0.39 1.63e-13 Body mass index; CRC cis rs9372498 0.536 rs7356947 chr6:118767920 A/G cg07617317 chr6:118971624 C6orf204 0.52 6.48 0.34 3.43e-10 Diastolic blood pressure; CRC trans rs4918814 0.869 rs7093880 chr10:115107503 A/G cg25339052 chr2:196399403 NA -0.39 -5.99 -0.31 5.37e-9 Neuroticism (multi-trait analysis); CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg05214047 chr5:56112645 MAP3K1 -0.52 -6.13 -0.32 2.48e-9 Diisocyanate-induced asthma; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg16106770 chr11:120206550 ARHGEF12 0.41 6.6 0.34 1.64e-10 Liver disease severity in Alagille syndrome; CRC cis rs12476592 0.543 rs2592387 chr2:63894834 C/T cg10828910 chr2:63850056 LOC388955 0.5 6.26 0.33 1.23e-9 Childhood ear infection; CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg08977639 chr16:1047820 NA -0.48 -6.21 -0.32 1.6e-9 Diisocyanate-induced asthma; CRC trans rs9291683 0.588 rs2240724 chr4:10021290 G/C cg26043149 chr18:55253948 FECH 0.51 7.85 0.4 5.94e-14 Bone mineral density; CRC cis rs1832871 0.672 rs12529235 chr6:158766950 A/G cg07165851 chr6:158734300 TULP4 0.62 7.81 0.4 7.61e-14 Height; CRC cis rs9467711 0.606 rs1977 chr6:26377546 A/G cg16898833 chr6:26189333 HIST1H4D 0.72 6.12 0.32 2.61e-9 Autism spectrum disorder or schizophrenia; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg04908186 chr3:170588253 RPL22L1 0.48 6.07 0.32 3.54e-9 Thyroid stimulating hormone; CRC cis rs3796352 1.000 rs35737577 chr3:53002557 G/C cg27565382 chr3:53032988 SFMBT1 0.7 6.27 0.33 1.11e-9 Immune reponse to smallpox (secreted IL-2); CRC cis rs394563 0.591 rs237019 chr6:149727064 G/A cg03678062 chr6:149772716 ZC3H12D -0.35 -6.25 -0.33 1.27e-9 Dupuytren's disease; CRC cis rs7258465 1.000 rs7251653 chr19:18608283 C/T cg10790698 chr19:18539756 SSBP4 -0.45 -8.6 -0.43 3.27e-16 Breast cancer; CRC cis rs1448094 0.765 rs4919773 chr12:86337559 C/T cg00310523 chr12:86230176 RASSF9 0.44 7.36 0.38 1.5e-12 Major depressive disorder; CRC cis rs7811142 0.830 rs11769057 chr7:99964661 A/G cg00814883 chr7:100076585 TSC22D4 -0.7 -8.85 -0.44 5.49e-17 Platelet count; CRC cis rs769267 0.930 rs4808965 chr19:19631655 A/G cg02546618 chr19:19431379 KIAA0892;SF4 0.45 6.19 0.32 1.79e-9 Tonsillectomy; CRC cis rs7659604 0.605 rs1507994 chr4:122749541 C/T cg20573242 chr4:122745356 CCNA2 0.61 9.82 0.48 3.97e-20 Type 2 diabetes; CRC cis rs11098499 0.865 rs28845498 chr4:120405186 G/A cg09307838 chr4:120376055 NA 0.7 10.94 0.52 5.84e-24 Corneal astigmatism; CRC cis rs1185460 0.967 rs1786684 chr11:118938435 G/A cg23280166 chr11:118938394 VPS11 0.44 6.71 0.35 8.71e-11 Coronary artery disease; CRC cis rs5769707 0.967 rs9616327 chr22:50010891 G/A cg20744362 chr22:50050164 C22orf34 0.34 6.76 0.35 6.3e-11 Monocyte count;Monocyte percentage of white cells; CRC cis rs7726839 0.540 rs72703095 chr5:601789 T/C cg16447950 chr5:562315 NA -0.74 -9.75 -0.47 6.69e-20 Obesity-related traits; CRC cis rs2204008 0.777 rs114096617 chr12:38342557 A/C cg26384229 chr12:38710491 ALG10B 0.69 9.71 0.47 9.43e-20 Bladder cancer; CRC cis rs9527 0.590 rs12246739 chr10:104787019 A/C cg04362960 chr10:104952993 NT5C2 -0.58 -8.09 -0.41 1.13e-14 Arsenic metabolism; CRC cis rs7659604 0.791 rs57316471 chr4:122663939 A/G cg06713675 chr4:122721982 EXOSC9 -0.39 -6.28 -0.33 1.06e-9 Type 2 diabetes; CRC trans rs1455244 0.700 rs7229302 chr18:11508904 G/T cg25057861 chr10:72142518 LRRC20 0.4 6.12 0.32 2.64e-9 Schizophrenia; CRC cis rs67311347 1.000 rs2168111 chr3:40395325 T/G cg09455208 chr3:40491958 NA 0.43 9.02 0.45 1.59e-17 Renal cell carcinoma; CRC cis rs921968 0.541 rs3755041 chr2:219442499 A/T cg02176678 chr2:219576539 TTLL4 -0.56 -8.95 -0.44 2.63e-17 Mean corpuscular hemoglobin concentration; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg06985934 chr11:61584717 FADS1 0.32 6.22 0.32 1.55e-9 Liver disease severity in Alagille syndrome; CRC cis rs854765 0.547 rs4368210 chr17:17896090 A/G cg09796270 chr17:17721594 SREBF1 -0.46 -7.55 -0.38 4.33e-13 Total body bone mineral density; CRC cis rs2760061 0.819 rs3094914 chr1:228206934 C/T cg02753203 chr1:228287806 NA 0.71 10.94 0.52 5.68e-24 Diastolic blood pressure; CRC cis rs6502050 0.835 rs7219180 chr17:80079968 C/G cg19223190 chr17:80058835 NA -0.39 -6.09 -0.32 3.17e-9 Life satisfaction; CRC cis rs9487051 0.799 rs830553 chr6:109550017 T/G cg21918786 chr6:109611834 NA -0.36 -6.11 -0.32 2.87e-9 Reticulocyte fraction of red cells; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg18091465 chr15:82551086 EFTUD1 -0.39 -6.38 -0.33 6.12e-10 Liver disease severity in Alagille syndrome; CRC cis rs7429990 0.901 rs6442091 chr3:48043058 T/C cg11946769 chr3:48343235 NME6 -0.5 -6.34 -0.33 7.42e-10 Educational attainment (years of education); CRC cis rs7258465 1.000 rs8109573 chr19:18617151 G/T cg10790698 chr19:18539756 SSBP4 -0.45 -8.56 -0.43 4.31e-16 Breast cancer; CRC cis rs66573146 0.803 rs60228659 chr4:7031704 G/A cg15105060 chr4:7024189 TBC1D14 -0.64 -5.63 -0.3 3.97e-8 Granulocyte percentage of myeloid white cells; CRC trans rs7395662 0.591 rs7482521 chr11:48609735 G/A cg00717180 chr2:96193071 NA -0.37 -5.97 -0.31 6.27e-9 HDL cholesterol; CRC cis rs172166 0.515 rs2622320 chr6:28115336 T/A cg23161317 chr6:28129485 ZNF389 0.39 5.81 0.31 1.45e-8 Cardiac Troponin-T levels; CRC cis rs17270561 0.609 rs4132072 chr6:25717843 C/T cg16482183 chr6:26056742 HIST1H1C 0.74 9.47 0.46 5.46e-19 Iron status biomarkers; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg26115449 chr3:180707572 DNAJC19 0.41 6.51 0.34 2.77e-10 Liver disease severity in Alagille syndrome; CRC cis rs9611565 0.659 rs4822037 chr22:41945113 G/T cg03806693 chr22:41940476 POLR3H -1.14 -15.19 -0.64 7.72e-40 Vitiligo; CRC cis rs79349575 0.783 rs12601858 chr17:47017477 T/C cg00947319 chr17:47005597 UBE2Z -0.34 -5.89 -0.31 9.32e-9 Type 2 diabetes; CRC cis rs2075371 1.000 rs378358 chr7:133970628 A/G cg20476274 chr7:133979776 SLC35B4 0.78 14.05 0.61 1.95e-35 Mean platelet volume; CRC cis rs9649213 0.593 rs6969731 chr7:97924571 T/G cg21770322 chr7:97807741 LMTK2 0.5 8.23 0.41 4.49e-15 Prostate cancer (SNP x SNP interaction); CRC trans rs6951245 0.832 rs79808627 chr7:1092519 C/G cg13565492 chr6:43139072 SRF -0.54 -6.13 -0.32 2.45e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs10982256 1.000 rs4979413 chr9:117259548 A/G cg13636371 chr9:117264095 DFNB31 0.37 7.18 0.37 4.72e-12 Bipolar disorder; CRC cis rs7177699 0.557 rs4433781 chr15:79121835 A/T cg00540400 chr15:79124168 NA -0.3 -5.61 -0.3 4.28e-8 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; CRC cis rs6062302 0.534 rs1556456 chr20:62216289 T/C cg09650180 chr20:62225654 GMEB2 -0.5 -6.65 -0.34 1.23e-10 Glioblastoma; CRC cis rs10504229 0.906 rs7003285 chr8:58173108 A/G cg02290350 chr8:58132656 NA -0.42 -5.96 -0.31 6.62e-9 Developmental language disorder (linguistic errors); CRC cis rs7945705 0.692 rs2742470 chr11:9004002 C/T cg12365402 chr11:9010492 NRIP3 -0.58 -10.64 -0.51 6.65e-23 Hemoglobin concentration; CRC cis rs10193935 0.901 rs10196091 chr2:42541591 T/C cg27598129 chr2:42591480 NA -0.58 -6.84 -0.35 3.97e-11 Colonoscopy-negative controls vs population controls; CRC cis rs155076 0.711 rs4769158 chr13:21881975 T/C cg23743428 chr13:21893420 NA -0.39 -5.91 -0.31 8.78e-9 White matter hyperintensity burden; CRC cis rs2732480 0.577 rs2634680 chr12:48734564 T/C cg24011408 chr12:48396354 COL2A1 0.47 6.39 0.33 5.64e-10 Hemoglobin concentration;Red blood cell count;Hematocrit; CRC cis rs2297440 0.506 rs2236504 chr20:62224762 C/T cg16989086 chr20:62203971 PRIC285 0.47 6.03 0.32 4.52e-9 Glioma;Non-glioblastoma glioma;Glioblastoma; CRC cis rs908922 0.628 rs488393 chr1:152489548 C/T cg23254163 chr1:152506842 NA 0.45 8.81 0.44 7.19e-17 Hair morphology; CRC cis rs12188164 0.965 rs11745789 chr5:450777 T/C cg26850624 chr5:429559 AHRR -0.81 -13.82 -0.61 1.41e-34 Cystic fibrosis severity; CRC cis rs1707322 0.627 rs3014213 chr1:46045522 T/C cg03146154 chr1:46216737 IPP -0.67 -9.58 -0.47 2.54e-19 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs6938 0.514 rs35556055 chr15:75253414 G/A cg21523564 chr15:75251491 NA 0.41 6.08 0.32 3.42e-9 Breast cancer; CRC cis rs5750830 0.649 rs4821894 chr22:39809820 G/C cg05872129 chr22:39784769 NA -0.57 -10.08 -0.49 5.21e-21 Intelligence (multi-trait analysis); CRC cis rs739496 0.542 rs7312913 chr12:111793552 A/G cg10833066 chr12:111807467 FAM109A 0.55 7.19 0.37 4.47e-12 Platelet count; CRC cis rs7224685 0.539 rs2054039 chr17:4014538 C/A cg05562828 chr17:3906858 NA 0.57 9.75 0.47 6.53e-20 Type 2 diabetes; CRC cis rs548181 0.621 rs2912098 chr11:125528569 C/T cg03464685 chr11:125439445 EI24 1.07 11.38 0.53 1.58e-25 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs1568889 1.000 rs16917687 chr11:28062614 G/A cg06544937 chr11:28130018 METT5D1;KIF18A 0.78 11.27 0.53 3.9e-25 Bipolar disorder; CRC cis rs76878669 0.561 rs4630308 chr11:66162587 G/A cg24851651 chr11:66362959 CCS -0.39 -6.86 -0.35 3.45e-11 Educational attainment (years of education); CRC cis rs7635838 0.785 rs2606735 chr3:11400714 A/C cg00170343 chr3:11313890 ATG7 0.44 6.54 0.34 2.29e-10 HDL cholesterol; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg08118649 chr12:99038419 APAF1;IKBIP 0.43 6.99 0.36 1.54e-11 Liver disease severity in Alagille syndrome; CRC cis rs1448094 0.511 rs11117023 chr12:86145329 G/A cg06740227 chr12:86229804 RASSF9 -0.37 -5.64 -0.3 3.71e-8 Major depressive disorder; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg08136276 chr4:83351514 HNRPDL;ENOPH1 0.43 5.98 0.31 5.86e-9 Anxiety disorder; CRC cis rs12612619 0.761 rs34732613 chr2:27254796 T/C cg00617064 chr2:27272375 NA -0.38 -6.37 -0.33 6.23e-10 Venous thromboembolism adjusted for sickle cell variant rs77121243-T; CRC cis rs889398 0.617 rs4985447 chr16:69885166 G/A cg00738113 chr16:70207722 CLEC18C -0.37 -6.44 -0.33 4.24e-10 Body mass index; CRC cis rs13108904 0.840 rs3915420 chr4:1260337 T/C cg21620606 chr4:1342894 KIAA1530 0.38 6.54 0.34 2.3e-10 Obesity-related traits; CRC trans rs9329221 0.736 rs11249999 chr8:10251265 C/T cg06636001 chr8:8085503 FLJ10661 -0.51 -7.61 -0.39 2.87e-13 Neuroticism; CRC cis rs11255291 0.668 rs719748 chr10:7731885 A/G cg13340899 chr10:7670827 ITIH5 0.38 5.64 0.3 3.61e-8 Ovarian reserve; CRC trans rs6703335 0.870 rs10803142 chr1:243598234 A/G cg27524519 chr4:84377120 HELQ;MRPS18C 0.42 6.05 0.32 3.92e-9 Schizophrenia;Schizophrenia, schizoaffective disorder or bipolar disorder; CRC cis rs72772090 0.539 rs2042386 chr5:96156783 C/T cg17330273 chr5:96107758 CAST;ERAP1 -0.63 -6.08 -0.32 3.36e-9 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs10504229 0.554 rs17802082 chr8:58095867 C/T cg02290350 chr8:58132656 NA -0.45 -5.75 -0.3 2.01e-8 Developmental language disorder (linguistic errors); CRC cis rs9549367 0.789 rs9549708 chr13:113891887 A/G cg18105134 chr13:113819100 PROZ -0.72 -10.35 -0.5 6.25e-22 Platelet distribution width; CRC cis rs1552244 0.882 rs17050672 chr3:10025463 G/A cg16606324 chr3:10149918 C3orf24 0.58 7.03 0.36 1.19e-11 Alzheimer's disease; CRC cis rs13108904 0.967 rs900029 chr4:1279145 C/T cg19318889 chr4:1322082 MAEA 0.39 5.61 0.3 4.3e-8 Obesity-related traits; CRC cis rs2033711 0.870 rs11084545 chr19:58951693 G/C cg00825309 chr19:58991885 ZNF446 -0.44 -6.42 -0.33 4.84e-10 Uric acid clearance; CRC cis rs10791097 0.582 rs2282578 chr11:130735691 A/T cg12179176 chr11:130786555 SNX19 0.76 12.49 0.57 1.44e-29 Autism spectrum disorder or schizophrenia;Schizophrenia; CRC cis rs9611565 0.765 rs132909 chr22:41802031 G/A cg06634786 chr22:41940651 POLR3H 0.61 7.09 0.36 8.08e-12 Vitiligo; CRC cis rs2084637 0.965 rs118028534 chr11:122420646 G/A cg21585512 chr11:122030076 LOC399959 -0.38 -6.72 -0.35 7.98e-11 Stroke; CRC cis rs10878977 0.542 rs17225223 chr12:69810208 C/T cg20891283 chr12:69753455 YEATS4 -0.61 -5.97 -0.31 6.31e-9 Colorectal cancer; CRC trans rs7267979 0.816 rs409853 chr20:25506067 T/C cg17903999 chr18:56338584 MALT1 -0.4 -6.54 -0.34 2.33e-10 Liver enzyme levels (alkaline phosphatase); CRC cis rs7107174 1.000 rs10899456 chr11:78000155 C/G cg02023728 chr11:77925099 USP35 0.5 7.72 0.39 1.41e-13 Testicular germ cell tumor; CRC cis rs8099014 0.906 rs4940692 chr18:56099715 A/G cg19312305 chr18:56117016 MIR122 -0.33 -5.61 -0.3 4.3e-8 Platelet count; CRC cis rs12980942 0.872 rs3816052 chr19:41773797 C/T cg25627403 chr19:41769009 HNRNPUL1 0.44 5.69 0.3 2.78e-8 Coronary artery disease; CRC cis rs10752881 0.967 rs6695746 chr1:182991355 T/C ch.1.3577855R chr1:183094577 LAMC1 0.86 15.17 0.64 8.93e-40 Colorectal cancer; CRC cis rs2832191 0.935 rs11910316 chr21:30519729 G/A cg24692254 chr21:30365293 RNF160 -0.61 -10.44 -0.5 3.11e-22 Dental caries; CRC cis rs9309711 0.772 rs9309715 chr2:3492318 C/G cg10845886 chr2:3471009 TTC15 0.7 11.25 0.53 4.58e-25 Neurofibrillary tangles; CRC cis rs7666738 0.830 rs28619044 chr4:98789814 G/C cg05340658 chr4:99064831 C4orf37 0.55 8.16 0.41 7.26e-15 Colonoscopy-negative controls vs population controls; CRC cis rs2424590 1.000 rs2424591 chr20:23637093 G/T cg16589663 chr20:23618590 CST3 -0.51 -6.85 -0.35 3.56e-11 Blood protein levels; CRC cis rs282587 0.597 rs1278659 chr13:113386497 G/T cg04656015 chr13:113407548 ATP11A 0.62 7.65 0.39 2.17e-13 Glycated hemoglobin levels; CRC cis rs17331151 0.573 rs3755801 chr3:52865798 G/A cg06204229 chr3:52865917 ITIH4 0.56 8.07 0.41 1.31e-14 Immune reponse to smallpox (secreted IL-2); CRC trans rs10021731 0.692 rs11722125 chr4:115411530 C/G cg25927708 chr2:119603813 EN1 -0.33 -6.01 -0.31 4.92e-9 Optic disc area; CRC trans rs1814175 0.817 rs10769641 chr11:49960141 A/G cg11707556 chr5:10655725 ANKRD33B -0.42 -8.01 -0.4 2.02e-14 Height; CRC cis rs1862618 0.853 rs252919 chr5:56124111 T/C cg12311346 chr5:56204834 C5orf35 -0.76 -10.06 -0.48 6.39e-21 Initial pursuit acceleration; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg26806071 chr4:154074259 TRIM2 0.44 6.09 0.32 3.14e-9 Response to antipsychotic treatment; CRC cis rs9649213 0.555 rs67132564 chr7:98014900 T/A cg21770322 chr7:97807741 LMTK2 0.53 8.66 0.43 2.14e-16 Prostate cancer (SNP x SNP interaction); CRC cis rs2153535 0.580 rs2143354 chr6:8517907 G/A cg21535247 chr6:8435926 SLC35B3 0.49 7.47 0.38 7.33e-13 Motion sickness; CRC cis rs28386778 0.897 rs4968597 chr17:61805747 G/A cg06873352 chr17:61820015 STRADA 0.76 14.26 0.62 2.98e-36 Prudent dietary pattern; CRC trans rs10506458 0.915 rs12423078 chr12:63397529 C/T cg22491629 chr6:157744540 C6orf35 -0.79 -9.28 -0.46 2.36e-18 Hemostatic factors and hematological phenotypes; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg07140808 chr4:78978772 FRAS1 0.54 7.73 0.39 1.3e-13 Response to antipsychotic treatment; CRC cis rs1953600 0.754 rs2573348 chr10:81925785 C/T cg04850286 chr10:81895943 PLAC9 -0.37 -6.69 -0.35 9.53e-11 Sarcoidosis; CRC cis rs6545883 0.929 rs1838978 chr2:61540923 T/C cg15711740 chr2:61764176 XPO1 0.48 6.48 0.34 3.33e-10 Tuberculosis; CRC cis rs10504229 0.724 rs73603871 chr8:58107612 A/G cg21724239 chr8:58056113 NA 0.52 6.99 0.36 1.58e-11 Developmental language disorder (linguistic errors); CRC cis rs853679 0.517 rs9368555 chr6:28108967 T/C cg25164649 chr6:28176230 NA 0.78 9.66 0.47 1.33e-19 Depression; CRC cis rs4713118 0.869 rs9468214 chr6:27713299 G/C cg08798685 chr6:27730294 NA -0.43 -6.17 -0.32 1.95e-9 Parkinson's disease; CRC cis rs4332037 0.851 rs73050128 chr7:1961882 C/A cg25834613 chr7:1915315 MAD1L1 -0.47 -6.76 -0.35 6.28e-11 Bipolar disorder; CRC cis rs34375054 0.738 rs10846834 chr12:125625570 A/G cg06987292 chr12:125626746 AACS -0.34 -5.87 -0.31 1.09e-8 Post bronchodilator FEV1/FVC ratio; CRC trans rs2303319 0.504 rs62189054 chr2:162624654 C/G cg14875682 chr5:52083620 ITGA1;PELO -0.73 -6.12 -0.32 2.59e-9 Cognitive function; CRC cis rs9916302 0.904 rs4795356 chr17:37535631 C/T cg00129232 chr17:37814104 STARD3 0.53 7.9 0.4 4.13e-14 Glomerular filtration rate (creatinine); CRC cis rs7605827 0.930 rs7601661 chr2:15597409 A/G cg19274914 chr2:15703543 NA 0.39 5.96 0.31 6.58e-9 Educational attainment (years of education); CRC cis rs5753618 0.583 rs5753615 chr22:31828027 T/C cg07713946 chr22:31675144 LIMK2 0.39 5.98 0.31 5.9e-9 Colorectal cancer; CRC cis rs2976388 0.506 rs2572902 chr8:143791387 A/G cg22687807 chr8:143858763 LYNX1 0.51 9.17 0.45 5.35e-18 Urinary tract infection frequency; CRC cis rs910316 0.875 rs12588099 chr14:75594462 A/T cg11812906 chr14:75593930 NEK9 0.64 10.04 0.48 7.52e-21 Height; CRC cis rs7647973 1.000 rs6805609 chr3:49471522 C/G cg07636037 chr3:49044803 WDR6 -0.65 -7.81 -0.4 7.91e-14 Menarche (age at onset); CRC cis rs7224737 1.000 rs9903204 chr17:40288062 G/A cg02228675 chr17:40259724 DHX58 -0.49 -6.9 -0.36 2.7e-11 Fibrinogen levels; CRC cis rs2749592 0.550 rs12255038 chr10:37869332 T/C cg00409905 chr10:38381863 ZNF37A 0.59 9.46 0.46 6.03e-19 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs4474465 0.646 rs10793337 chr11:78285875 A/T cg27205649 chr11:78285834 NARS2 0.52 6.73 0.35 7.7e-11 Alzheimer's disease (survival time); CRC cis rs8077889 0.871 rs17675370 chr17:41900030 T/C cg26893861 chr17:41843967 DUSP3 0.95 12.3 0.56 7.2e-29 Triglycerides; CRC cis rs6788895 1.000 rs2014279 chr3:150487945 G/T cg09723797 chr3:150481914 SIAH2 0.75 6.29 0.33 9.85e-10 Breast cancer; CRC trans rs3960554 0.529 rs1859795 chr7:75877354 A/G cg19862616 chr7:65841803 NCRNA00174 0.47 6.41 0.33 4.96e-10 Eotaxin levels; CRC cis rs7633770 0.786 rs4683256 chr3:46683617 T/G cg11219411 chr3:46661640 NA 0.53 8.47 0.42 8.46e-16 Coronary artery disease; CRC cis rs6860806 0.507 rs273917 chr5:131659618 A/G cg24060327 chr5:131705240 SLC22A5 -0.53 -7.81 -0.4 7.58e-14 Breast cancer; CRC cis rs7216064 1.000 rs62085993 chr17:65923152 T/C cg12091567 chr17:66097778 LOC651250 -0.62 -7.2 -0.37 4.18e-12 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CRC cis rs4803468 0.967 rs3786553 chr19:41902746 T/G cg09537434 chr19:41945824 ATP5SL -0.91 -17.72 -0.7 8.56e-50 Height; CRC cis rs4970988 0.556 rs6695123 chr1:150563483 T/C cg15448220 chr1:150897856 SETDB1 -0.45 -6.43 -0.33 4.58e-10 Urate levels; CRC trans rs2303319 0.504 rs58622044 chr2:162596287 A/G cg20397358 chr22:38597902 MAFF -0.71 -6.17 -0.32 2.03e-9 Cognitive function; CRC cis rs28386778 0.897 rs2156903 chr17:61937179 G/A cg06601766 chr17:61851465 DDX42;CCDC47 0.42 5.8 0.3 1.55e-8 Prudent dietary pattern; CRC cis rs9322193 1.000 rs9377228 chr6:149921998 G/A cg05861140 chr6:150128134 PCMT1 -0.36 -5.92 -0.31 8.15e-9 Lung cancer; CRC cis rs17767392 0.958 rs12879243 chr14:71905815 C/G cg13720639 chr14:72061746 SIPA1L1 -0.55 -7.04 -0.36 1.13e-11 Mitral valve prolapse; CRC trans rs2303319 0.504 rs1023835 chr2:162593973 A/G cg12500891 chr11:57225987 NA -0.65 -6.06 -0.32 3.77e-9 Cognitive function; CRC trans rs10506458 1.000 rs73127086 chr12:63415626 G/A cg03429785 chr15:59498649 MYO1E;LDHAL6B -1.35 -19.57 -0.73 4.38e-57 Hemostatic factors and hematological phenotypes; CRC cis rs12410462 0.892 rs75757169 chr1:227629855 A/G cg04117972 chr1:227635322 NA 0.7 7.84 0.4 6.22e-14 Major depressive disorder; CRC cis rs6952808 1.000 rs6978048 chr7:1886872 T/G cg22963979 chr7:1858916 MAD1L1 -0.66 -10.09 -0.49 4.87e-21 Bipolar disorder and schizophrenia; CRC cis rs7927592 0.913 rs7107622 chr11:68374183 T/C cg01657329 chr11:68192670 LRP5 -0.49 -7.43 -0.38 9.34e-13 Total body bone mineral density; CRC cis rs10504229 0.683 rs59528137 chr8:58138565 C/T cg11062466 chr8:58055876 NA 0.57 7.05 0.36 1.04e-11 Developmental language disorder (linguistic errors); CRC cis rs7613875 0.600 rs1138536 chr3:50153356 C/T cg24308560 chr3:49941425 MST1R -0.41 -6.15 -0.32 2.24e-9 Body mass index; CRC cis rs9837602 0.529 rs1688774 chr3:99521108 C/T cg07805332 chr3:99536008 MIR548G;C3orf26 0.52 7.72 0.39 1.45e-13 Breast cancer; CRC trans rs7267979 1.000 rs6083856 chr20:25407585 C/T cg17903999 chr18:56338584 MALT1 0.42 6.97 0.36 1.75e-11 Liver enzyme levels (alkaline phosphatase); CRC cis rs11971779 0.680 rs4732370 chr7:139077240 A/C cg23387468 chr7:139079360 LUC7L2 -0.41 -7.18 -0.37 4.57e-12 Diisocyanate-induced asthma; CRC cis rs4665809 1.000 rs11678157 chr2:26321526 T/C cg04944784 chr2:26401820 FAM59B -0.58 -7.59 -0.39 3.25e-13 Gut microbiome composition (summer); CRC cis rs6952808 0.582 rs871925 chr7:2047875 G/A cg04267008 chr7:1944627 MAD1L1 0.6 8.73 0.43 1.35e-16 Bipolar disorder and schizophrenia; CRC cis rs6429082 0.967 rs704710 chr1:235621026 A/G cg26050004 chr1:235667680 B3GALNT2 0.46 6.94 0.36 2.14e-11 Adiposity; CRC cis rs35306767 0.903 rs12244355 chr10:944465 T/C cg20503657 chr10:835505 NA 0.95 11.72 0.54 9.34e-27 Eosinophil percentage of granulocytes; CRC cis rs4862750 0.872 rs6830828 chr4:187897472 T/G cg07414643 chr4:187882934 NA 0.4 6.98 0.36 1.59e-11 Lobe attachment (rater-scored or self-reported); CRC cis rs896854 0.936 rs10108430 chr8:95961794 C/T cg13393036 chr8:95962371 TP53INP1 -0.52 -8.85 -0.44 5.45e-17 Type 2 diabetes; CRC cis rs4746818 0.901 rs10740317 chr10:70937566 G/A cg11621586 chr10:70884670 VPS26A 0.91 7.9 0.4 4.23e-14 Left atrial antero-posterior diameter; CRC cis rs1552244 0.554 rs4488814 chr3:10002400 C/T cg00166722 chr3:10149974 C3orf24 -0.45 -6.71 -0.35 8.54e-11 Alzheimer's disease; CRC cis rs34779708 0.966 rs1545757 chr10:35445588 A/T cg03585969 chr10:35415529 CREM 0.66 8.75 0.43 1.14e-16 Inflammatory bowel disease;Crohn's disease; CRC cis rs6860806 0.507 rs272880 chr5:131670178 C/T cg02033258 chr5:131593261 PDLIM4 0.38 6.48 0.34 3.39e-10 Breast cancer; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg09464487 chr12:100593423 ACTR6 0.44 6.06 0.32 3.79e-9 Response to antipsychotic treatment; CRC trans rs8108034 1.000 rs39587 chr19:39806997 C/T cg09731288 chr10:112632370 PDCD4 -0.6 -6.82 -0.35 4.32e-11 Lung adenocarcinoma; CRC cis rs6582630 0.555 rs10880520 chr12:38464111 C/T cg26384229 chr12:38710491 ALG10B 0.72 10.09 0.49 4.78e-21 Drug-induced liver injury (flucloxacillin); CRC cis rs2439831 0.850 rs16950562 chr15:44036364 G/A cg15269541 chr15:43626905 ADAL -0.5 -5.92 -0.31 8.13e-9 Lung cancer in ever smokers; CRC cis rs7633770 0.841 rs11130100 chr3:46679198 A/T cg11219411 chr3:46661640 NA -0.7 -12.3 -0.56 7.09e-29 Coronary artery disease; CRC cis rs9462846 1.000 rs56158882 chr6:42860740 T/G cg21280719 chr6:42927975 GNMT -0.33 -5.86 -0.31 1.11e-8 Blood protein levels; CRC trans rs7267979 0.932 rs4280527 chr20:25544014 A/G cg17903999 chr18:56338584 MALT1 -0.44 -7.32 -0.37 1.93e-12 Liver enzyme levels (alkaline phosphatase); CRC cis rs728616 0.764 rs117833443 chr10:81738136 A/C cg05935833 chr10:81318306 SFTPA2 -0.76 -8.28 -0.42 3.12e-15 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs7493 0.901 rs11764079 chr7:95026229 A/G cg20119798 chr7:94954144 PON1 0.39 5.62 0.3 4.01e-8 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs9533799 1.000 rs11620543 chr13:44798371 G/A cg19190762 chr13:44806055 NA 0.66 10.14 0.49 3.22e-21 Amyotrophic lateral sclerosis; CRC cis rs853679 0.598 rs9380054 chr6:28067537 G/A cg02683197 chr6:28174875 NA 0.82 10.05 0.48 6.9e-21 Depression; CRC cis rs9326248 0.520 rs74830 chr11:117090558 C/T cg11861562 chr11:117069780 TAGLN -0.32 -7.06 -0.36 9.83e-12 Blood protein levels; CRC cis rs72945132 0.882 rs4567496 chr11:70193208 A/T cg14191688 chr11:70257035 CTTN 0.46 5.93 0.31 7.67e-9 Coronary artery disease; CRC trans rs208520 1.000 rs208523 chr6:66954195 G/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.89 -11.02 -0.52 2.96e-24 Exhaled nitric oxide output; CRC cis rs6089584 0.854 rs2380146 chr20:60632233 C/T cg13770153 chr20:60521292 NA -0.61 -9.33 -0.46 1.63e-18 Body mass index; CRC cis rs6582630 0.599 rs7967598 chr12:38540760 C/T cg13010199 chr12:38710504 ALG10B -0.41 -5.83 -0.31 1.32e-8 Drug-induced liver injury (flucloxacillin); CRC cis rs9488822 0.676 rs1556857 chr6:116325559 T/C cg26893134 chr6:116381904 FRK 0.26 7.61 0.39 2.98e-13 Cholesterol, total;LDL cholesterol; CRC cis rs72634258 0.554 rs4562654 chr1:7934423 A/T cg26816564 chr1:7831052 VAMP3 0.79 8.95 0.44 2.56e-17 Inflammatory bowel disease; CRC cis rs11864453 0.560 rs6499561 chr16:72148404 A/G cg23815491 chr16:72088622 HP 0.51 7.9 0.4 4.32e-14 Fibrinogen levels; CRC cis rs812925 0.784 rs1177304 chr2:61388164 C/G cg10580144 chr2:61372316 C2orf74 0.32 6.24 0.33 1.32e-9 Immature fraction of reticulocytes; CRC cis rs654950 0.775 rs28972757 chr1:41993013 T/C cg06885757 chr1:42089581 HIVEP3 -0.35 -6.03 -0.32 4.49e-9 Airway imaging phenotypes; CRC cis rs67478160 0.595 rs1475007 chr14:104297147 A/G cg08213375 chr14:104286397 PPP1R13B 0.62 12.57 0.57 7.28e-30 Schizophrenia; CRC cis rs8072100 0.782 rs28507314 chr17:45551402 C/T cg25173405 chr17:45401733 C17orf57 -0.44 -6.77 -0.35 5.79e-11 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs67311347 1.000 rs4973878 chr3:40407565 C/T cg09455208 chr3:40491958 NA 0.43 8.83 0.44 6.18e-17 Renal cell carcinoma; CRC cis rs4474465 0.562 rs10793318 chr11:78215898 A/C cg27205649 chr11:78285834 NARS2 0.45 5.61 0.3 4.39e-8 Alzheimer's disease (survival time); CRC cis rs10782582 0.593 rs12132750 chr1:76136222 A/G cg03433033 chr1:76189801 ACADM -0.42 -6.15 -0.32 2.3e-9 Daytime sleep phenotypes; CRC cis rs3820928 1.000 rs4675116 chr2:227769607 A/C cg11843606 chr2:227700838 RHBDD1 -0.41 -5.88 -0.31 1.02e-8 Pulmonary function; CRC trans rs783540 0.874 rs10468217 chr15:83248079 T/C cg18393722 chr15:85113863 UBE2QP1 -0.35 -6.22 -0.32 1.54e-9 Schizophrenia; CRC cis rs877282 0.786 rs10904558 chr10:797509 C/T cg17470449 chr10:769945 NA 0.64 8.5 0.42 6.85e-16 Uric acid levels; CRC trans rs656319 0.625 rs4526366 chr8:9890179 C/G cg16141378 chr3:129829833 LOC729375 0.42 6.1 0.32 2.95e-9 Myopia (pathological); CRC cis rs17376456 0.809 rs12152763 chr5:93405509 T/A cg25358565 chr5:93447407 FAM172A 1.02 10.31 0.49 8.6e-22 Diabetic retinopathy; CRC cis rs7208859 0.623 rs59029591 chr17:29235746 A/C cg13385521 chr17:29058706 SUZ12P 0.69 7.99 0.4 2.27e-14 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs909674 0.541 rs5750812 chr22:39793079 G/A cg05872129 chr22:39784769 NA -0.64 -12.79 -0.58 1.08e-30 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; CRC trans rs7647973 0.626 rs35129566 chr3:49866584 T/G cg21659725 chr3:3221576 CRBN 0.66 7.3 0.37 2.24e-12 Menarche (age at onset); CRC cis rs10504229 0.569 rs75466737 chr8:58055034 A/G cg08219700 chr8:58056026 NA 0.58 6.69 0.35 9.52e-11 Developmental language disorder (linguistic errors); CRC cis rs7811142 1.000 rs6975514 chr7:100056220 T/C cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.99 13.68 0.6 4.96e-34 Platelet count; CRC cis rs9891119 0.576 rs35314169 chr17:40515826 C/T cg06270615 chr17:40516068 STAT3 -0.34 -7.17 -0.37 4.87e-12 Multiple sclerosis;Crohn's disease; CRC cis rs2398893 1.000 rs10993017 chr9:96760384 C/T cg14459158 chr9:96720562 NA -0.46 -7.56 -0.38 4.06e-13 Waist-hip ratio;Waist-to-hip ratio adjusted for body mass index; CRC cis rs10504229 0.679 rs12375285 chr8:58040084 G/A cg21724239 chr8:58056113 NA 0.52 7.04 0.36 1.1e-11 Developmental language disorder (linguistic errors); CRC cis rs1005277 0.579 rs1614236 chr10:38502996 C/T cg00409905 chr10:38381863 ZNF37A -0.64 -10.5 -0.5 1.92e-22 Extrinsic epigenetic age acceleration; CRC cis rs60871478 0.787 rs4720928 chr7:808002 T/C cg04727924 chr7:799746 HEATR2 -0.43 -6.61 -0.34 1.53e-10 Cerebrospinal P-tau181p levels; CRC trans rs1005277 0.579 rs2749612 chr10:38488610 G/A cg17830980 chr10:43048298 ZNF37B -0.59 -9.93 -0.48 1.75e-20 Extrinsic epigenetic age acceleration; CRC cis rs2739330 0.796 rs5760106 chr22:24250645 A/C cg11060661 chr22:24314208 DDT;DDTL -0.49 -8.37 -0.42 1.64e-15 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs362272 0.505 rs10155132 chr4:3369500 A/G cg11522145 chr4:3412961 RGS12 -0.38 -6.03 -0.32 4.41e-9 Serum sulfate level; CRC cis rs972578 0.967 rs7291153 chr22:43356499 C/T cg01576275 chr22:43409880 NA -0.46 -7.42 -0.38 9.77e-13 Mean platelet volume; CRC cis rs270601 0.721 rs270621 chr5:131605821 C/A cg18301423 chr5:131593218 PDLIM4 0.46 7.88 0.4 4.72e-14 Acylcarnitine levels; CRC cis rs34787248 1 rs34787248 chr6:28197886 C/T cg12273811 chr6:28175739 NA 0.58 6.36 0.33 6.76e-10 Autism spectrum disorder or schizophrenia; CRC cis rs2243480 0.901 rs778693 chr7:65872345 T/G cg25985355 chr7:65971099 NA -0.53 -5.98 -0.31 5.75e-9 Diabetic kidney disease; CRC cis rs7945705 0.935 rs1883098 chr11:8890594 G/A cg12365402 chr11:9010492 NRIP3 -0.49 -8.35 -0.42 1.99e-15 Hemoglobin concentration; CRC cis rs9462027 0.628 rs9469889 chr6:34763900 G/C cg07306190 chr6:34760872 UHRF1BP1 -0.35 -6.21 -0.32 1.58e-9 Systemic lupus erythematosus; CRC cis rs1957429 0.901 rs59876171 chr14:65384429 C/T cg23373153 chr14:65346875 NA -0.82 -8.53 -0.43 5.26e-16 Pediatric areal bone mineral density (radius); CRC trans rs3733585 0.673 rs9994937 chr4:9964799 G/T cg26043149 chr18:55253948 FECH -0.5 -7.62 -0.39 2.7e-13 Cleft plate (environmental tobacco smoke interaction); CRC cis rs6502050 0.835 rs35070385 chr17:80128447 G/A cg02741985 chr17:80059408 CCDC57 0.44 7.24 0.37 3.25e-12 Life satisfaction; CRC trans rs9354308 0.933 rs2022856 chr6:66568235 G/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.48 6.06 0.32 3.69e-9 Metabolite levels; CRC cis rs1799949 1.000 rs4793189 chr17:41190715 G/A cg05368731 chr17:41323189 NBR1 0.69 10.07 0.49 5.76e-21 Menopause (age at onset); CRC cis rs7927771 0.965 rs1064608 chr11:47640429 G/C cg18512352 chr11:47633146 NA -0.48 -9.62 -0.47 1.88e-19 Subjective well-being; CRC trans rs8002861 0.692 rs9533646 chr13:44410669 T/C cg12856521 chr11:46389249 DGKZ -0.5 -8.29 -0.42 2.85e-15 Leprosy; CRC cis rs7618915 0.547 rs2268026 chr3:52778347 T/C cg18404041 chr3:52824283 ITIH1 -0.43 -8.71 -0.43 1.54e-16 Bipolar disorder; CRC cis rs4969178 0.622 rs4129767 chr17:76403984 G/A cg05887092 chr17:76393375 PGS1 0.63 12.64 0.57 3.97e-30 HDL cholesterol levels; CRC cis rs2976388 0.590 rs10110970 chr8:143820410 G/C cg05569086 chr8:143859399 LYNX1 -0.39 -6.43 -0.33 4.45e-10 Urinary tract infection frequency; CRC cis rs9291683 0.567 rs12499857 chr4:9995376 G/A cg00071950 chr4:10020882 SLC2A9 0.64 11.8 0.55 4.81e-27 Bone mineral density; CRC cis rs7811142 0.830 rs73401451 chr7:99981895 T/C cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.61 7.88 0.4 4.81e-14 Platelet count; CRC cis rs6732160 0.564 rs7605716 chr2:73376250 G/A cg01422370 chr2:73384389 NA 0.37 5.78 0.3 1.74e-8 Intelligence (multi-trait analysis); CRC trans rs10504229 0.861 rs6990796 chr8:58183097 G/C cg04077850 chr5:125800366 GRAMD3 0.37 6.27 0.33 1.15e-9 Developmental language disorder (linguistic errors); CRC cis rs2742417 0.967 rs1534875 chr3:45741043 T/G cg04837898 chr3:45731254 SACM1L -0.36 -5.87 -0.31 1.09e-8 Response to anti-depressant treatment in major depressive disorder; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg22958951 chr11:119252637 USP2 0.47 6.55 0.34 2.27e-10 Response to antipsychotic treatment; CRC cis rs35306767 0.715 rs1250891 chr10:1040159 G/C cg26597838 chr10:835615 NA 0.95 11.06 0.52 2.17e-24 Eosinophil percentage of granulocytes; CRC cis rs951366 0.789 rs823152 chr1:205736285 G/A cg11965913 chr1:205819406 PM20D1 0.88 14.55 0.63 2.28e-37 Menarche (age at onset); CRC trans rs9929218 0.520 rs1078621 chr16:68778996 C/T cg04657470 chr2:198365150 HSPE1;HSPD1 0.92 16.04 0.66 3.39e-43 Colorectal cancer; CRC cis rs1355223 0.583 rs2956076 chr11:34874124 T/C cg11058730 chr11:34937778 PDHX;APIP 0.72 11.62 0.54 2.14e-26 Systemic lupus erythematosus and Systemic sclerosis; CRC cis rs1152591 0.811 rs1255986 chr14:64655161 A/G cg23250157 chr14:64679961 SYNE2 -0.52 -7.95 -0.4 2.96e-14 Atrial fibrillation; CRC cis rs449789 0.857 rs9355713 chr6:159722548 C/T cg14500486 chr6:159655392 FNDC1 -0.5 -7.56 -0.38 4.1e-13 Pulse pressure; CRC cis rs910316 1.000 rs11159117 chr14:75584867 C/T cg03030879 chr14:75389066 RPS6KL1 -0.47 -7.49 -0.38 6.57e-13 Height; CRC cis rs9359856 0.879 rs4707552 chr6:90300841 A/G cg13799429 chr6:90582589 CASP8AP2 0.47 6.55 0.34 2.17e-10 Bipolar disorder; CRC cis rs875971 0.862 rs2420611 chr7:65999320 A/G cg12463550 chr7:65579703 CRCP 0.47 6.43 0.33 4.41e-10 Aortic root size; CRC cis rs447735 0.587 rs11647958 chr16:89720909 A/T cg01097406 chr16:89675127 NA 0.38 7.34 0.38 1.69e-12 Hemoglobin concentration; CRC cis rs9303401 0.614 rs56284918 chr17:57178838 A/G cg02118635 chr17:56770003 RAD51C;TEX14 0.68 8.42 0.42 1.15e-15 Cognitive test performance; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg24639504 chr13:25875833 NUPL1 0.36 6.09 0.32 3.09e-9 Liver disease severity in Alagille syndrome; CRC cis rs4689592 0.546 rs2359012 chr4:7066053 A/C cg26116260 chr4:7069785 GRPEL1 0.98 14.86 0.63 1.36e-38 Monocyte percentage of white cells; CRC cis rs7224685 0.501 rs4790169 chr17:4022665 G/A cg21851534 chr17:3907994 ZZEF1 -0.36 -6.03 -0.32 4.41e-9 Type 2 diabetes; CRC cis rs7786877 0.508 rs11765509 chr7:100310990 T/G cg16850897 chr7:100343110 ZAN -0.59 -8.56 -0.43 4.24e-16 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs6500602 0.627 rs1641866 chr16:4593040 A/C cg14951292 chr16:4525986 HMOX2;NMRAL1 0.58 8.32 0.42 2.34e-15 Schizophrenia; CRC cis rs55871839 0.708 rs7000535 chr8:59804351 T/C cg07426533 chr8:59803705 TOX -0.38 -6.57 -0.34 2.02e-10 Pneumonia; CRC cis rs7224737 0.956 rs7208907 chr17:40284783 C/T cg02228675 chr17:40259724 DHX58 -0.5 -7.01 -0.36 1.38e-11 Fibrinogen levels; CRC cis rs34311866 0.808 rs11248060 chr4:964359 C/T cg14530993 chr4:882597 GAK 0.66 6.3 0.33 9.5e-10 Parkinson's disease; CRC cis rs7659604 0.539 rs11098646 chr4:122729301 T/C cg20573242 chr4:122745356 CCNA2 0.57 8.32 0.42 2.37e-15 Type 2 diabetes; CRC cis rs916888 0.610 rs199530 chr17:44836653 C/T cg01570182 chr17:44337453 NA -0.72 -9.36 -0.46 1.25e-18 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs539514 0.501 rs8000656 chr13:76400640 A/G cg04757411 chr13:76259545 LMO7 0.37 6.09 0.32 3.16e-9 Type 1 diabetes; CRC cis rs7843479 0.601 rs11780532 chr8:21838670 T/A cg17168535 chr8:21777572 XPO7 0.62 10.58 0.5 1.01e-22 Mean corpuscular volume; CRC cis rs2976388 0.647 rs2244163 chr8:143784500 T/G cg04969067 chr8:143858791 LYNX1 0.43 7.41 0.38 1.04e-12 Urinary tract infection frequency; CRC cis rs9435341 0.965 rs12401598 chr1:107580533 C/A cg11070056 chr1:107600091 PRMT6 0.4 5.65 0.3 3.55e-8 Facial morphology (factor 21, depth of nasal alae); CRC cis rs7923609 0.967 rs7076310 chr10:65135672 C/A cg08743896 chr10:65200160 JMJD1C -0.4 -5.76 -0.3 1.98e-8 Educational attainment;Liver enzyme levels (alkaline phosphatase); CRC cis rs9467711 0.538 rs9467632 chr6:25889706 A/G cg12315302 chr6:26189340 HIST1H4D 0.76 6.19 0.32 1.76e-9 Autism spectrum disorder or schizophrenia; CRC cis rs10849893 0.538 rs7961855 chr12:121829943 C/T cg01154721 chr12:121881891 KDM2B -0.42 -6.29 -0.33 9.94e-10 Fasting blood glucose;Fasting blood glucose (BMI interaction); CRC cis rs7639513 0.767 rs3806661 chr3:12705855 A/G cg23032965 chr3:12705835 RAF1 0.66 10.27 0.49 1.2e-21 Itch intensity from mosquito bite; CRC cis rs798766 0.953 rs13123646 chr4:1740539 T/C cg05874882 chr4:1763078 NA -0.38 -7.09 -0.36 8.04e-12 Bladder cancer;Urinary bladder cancer; CRC cis rs12024301 0.557 rs6674368 chr1:183603375 G/T cg11505048 chr1:183622726 RGL1;APOBEC4 0.75 6.8 0.35 5.02e-11 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs7666738 0.830 rs10028692 chr4:98962585 C/T cg17366294 chr4:99064904 C4orf37 0.43 7.36 0.38 1.49e-12 Colonoscopy-negative controls vs population controls; CRC cis rs79839061 0.666 rs62297063 chr4:869708 G/A cg14530993 chr4:882597 GAK 0.82 7.82 0.4 7.42e-14 Intelligence (multi-trait analysis); CRC cis rs10504229 1.000 rs17217082 chr8:58180918 G/A cg02290350 chr8:58132656 NA -0.42 -5.96 -0.31 6.62e-9 Developmental language disorder (linguistic errors); CRC cis rs73206853 0.841 rs73191819 chr12:110920182 C/T cg12870014 chr12:110450643 ANKRD13A 0.75 8.02 0.4 1.88e-14 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC cis rs7208859 0.623 rs28627615 chr17:29145817 G/C cg01831904 chr17:28903510 LRRC37B2 -0.62 -6.41 -0.33 5.13e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC trans rs2228479 1.000 rs11642267 chr16:89957635 T/C cg24644049 chr4:85504048 CDS1 0.91 7.97 0.4 2.59e-14 Skin colour saturation; CRC cis rs4332037 0.713 rs56093134 chr7:1973970 C/T cg23422044 chr7:1970798 MAD1L1 -0.63 -7.69 -0.39 1.69e-13 Bipolar disorder; CRC cis rs7647973 0.580 rs35218722 chr3:49275805 A/G cg07636037 chr3:49044803 WDR6 0.82 12.55 0.57 8.88e-30 Menarche (age at onset); CRC cis rs9902453 0.967 rs62070344 chr17:28476997 C/G cg26525008 chr17:28256777 EFCAB5;SSH2 0.56 8.44 0.42 1.03e-15 Coffee consumption (cups per day); CRC cis rs12451471 0.620 rs11150846 chr17:78098520 C/T cg24585782 chr17:78113791 EIF4A3 -0.47 -6.54 -0.34 2.37e-10 Plateletcrit;Mean corpuscular hemoglobin concentration; CRC cis rs9549367 0.713 rs9549681 chr13:113829873 T/C cg00898013 chr13:113819073 PROZ -0.58 -8.22 -0.41 4.72e-15 Platelet distribution width; CRC cis rs812925 0.784 rs6735081 chr2:61460717 C/T cg10580144 chr2:61372316 C2orf74 -0.32 -6.64 -0.34 1.27e-10 Immature fraction of reticulocytes; CRC cis rs6502050 0.871 rs62079998 chr17:80077245 A/C cg25804541 chr17:80189381 SLC16A3 0.32 6.24 0.33 1.33e-9 Life satisfaction; CRC cis rs3736485 0.844 rs8024506 chr15:51792934 C/T cg08986416 chr15:51914746 DMXL2 -0.45 -6.41 -0.33 5.03e-10 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs9611565 0.877 rs3817999 chr22:41747717 A/G cg03806693 chr22:41940476 POLR3H 0.68 9.45 0.46 6.58e-19 Vitiligo; CRC cis rs12348691 0.503 rs7847259 chr9:100600712 A/G cg13688889 chr9:100608707 NA -0.47 -6.03 -0.32 4.44e-9 Alopecia areata; CRC cis rs637571 0.522 rs12792888 chr11:65761446 C/T cg02427764 chr11:65769310 BANF1;EIF1AD 0.4 5.62 0.3 4.13e-8 Eosinophil percentage of white cells; CRC cis rs1519814 1.000 rs7818027 chr8:121158662 G/C cg22335954 chr8:121166405 COL14A1 -0.59 -6.83 -0.35 4.11e-11 Breast cancer; CRC cis rs4919694 0.572 rs12240508 chr10:104939232 G/A cg04362960 chr10:104952993 NT5C2 0.89 9.24 0.45 3.25e-18 Arsenic metabolism; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg26976181 chr19:18434160 LSM4 0.43 6.24 0.33 1.37e-9 Intelligence (multi-trait analysis); CRC cis rs9322193 0.887 rs9505824 chr6:149954799 A/G cg05861140 chr6:150128134 PCMT1 -0.36 -5.92 -0.31 8.26e-9 Lung cancer; CRC cis rs4713118 0.586 rs6905522 chr6:28086479 A/C cg23161317 chr6:28129485 ZNF389 0.54 6.56 0.34 2.12e-10 Parkinson's disease; CRC cis rs1552244 0.554 rs17050705 chr3:10046398 G/C cg13047869 chr3:10149882 C3orf24 0.38 5.93 0.31 7.73e-9 Alzheimer's disease; CRC cis rs7412746 0.658 rs1546376 chr1:150937661 A/G cg10589385 chr1:150898437 SETDB1 0.32 6.79 0.35 5.21e-11 Melanoma; CRC cis rs1707322 1.000 rs10890350 chr1:46262378 G/A cg06784218 chr1:46089804 CCDC17 0.5 8.81 0.44 7.43e-17 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC trans rs13046373 0.905 rs4816372 chr21:32077414 A/T cg04849180 chr8:52921640 NA -0.37 -5.98 -0.31 5.83e-9 HDL cholesterol; CRC cis rs3751196 0.710 rs59651914 chr12:104222211 T/A cg02344784 chr12:104178138 NT5DC3 0.69 7.04 0.36 1.1e-11 Sense of smell; CRC cis rs12594515 1.000 rs8027000 chr15:45987795 T/C cg06207120 chr15:45996521 NA 0.32 7.75 0.39 1.14e-13 Waist circumference;Weight; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg21845817 chr2:96068451 FAHD2A 0.45 6.44 0.33 4.12e-10 Anxiety disorder; CRC cis rs9902453 0.845 rs2321493 chr17:28230359 T/C cg26525008 chr17:28256777 EFCAB5;SSH2 0.57 8.62 0.43 2.93e-16 Coffee consumption (cups per day); CRC cis rs10751667 0.666 rs11246358 chr11:967349 G/A cg01483505 chr11:975446 AP2A2 0.43 6.96 0.36 1.87e-11 Alzheimer's disease (late onset); CRC cis rs67311347 0.544 rs12054197 chr3:40337562 C/T cg09455208 chr3:40491958 NA 0.31 6.34 0.33 7.75e-10 Renal cell carcinoma; CRC cis rs10782582 0.609 rs80059220 chr1:76279112 G/T cg10523679 chr1:76189770 ACADM -0.4 -5.68 -0.3 2.93e-8 Daytime sleep phenotypes; CRC cis rs10504229 1.000 rs67594249 chr8:58180521 T/A cg05313129 chr8:58192883 C8orf71 -0.47 -6.99 -0.36 1.49e-11 Developmental language disorder (linguistic errors); CRC cis rs1448094 0.845 rs17354637 chr12:86347752 A/G cg18827107 chr12:86230957 RASSF9 -0.43 -6.79 -0.35 5.29e-11 Major depressive disorder; CRC cis rs4665809 0.589 rs4665842 chr2:26448954 A/G cg26119090 chr2:26468346 HADHA;HADHB -1.06 -15.56 -0.65 2.61e-41 Gut microbiome composition (summer); CRC cis rs1401999 0.659 rs7622660 chr3:183753337 C/T cg05044414 chr3:183734942 ABCC5 0.46 7.6 0.39 3.1e-13 Anterior chamber depth; CRC cis rs921968 0.565 rs7605055 chr2:219627050 G/C cg02176678 chr2:219576539 TTLL4 -0.39 -6.31 -0.33 8.79e-10 Mean corpuscular hemoglobin concentration; CRC cis rs2840044 1.000 rs11080357 chr17:33898933 G/A cg05299278 chr17:33885742 SLFN14 -0.41 -6.24 -0.33 1.33e-9 Response to radiotherapy in cancer (late toxicity); CRC cis rs5769765 0.773 rs9616383 chr22:50313014 T/C cg22709217 chr22:50311962 ALG12;CRELD2 -1.12 -18.26 -0.71 6.49e-52 Schizophrenia; CRC cis rs9910055 0.529 rs850851 chr17:42177674 C/T cg09913183 chr17:42254507 C17orf65;ASB16 -0.5 -6.76 -0.35 6.19e-11 Total body bone mineral density; CRC cis rs9649213 0.555 rs7785612 chr7:97933867 T/A cg24562669 chr7:97807699 LMTK2 0.45 7.59 0.39 3.4e-13 Prostate cancer (SNP x SNP interaction); CRC cis rs7542091 0.635 rs985431 chr1:210043948 A/T cg05527609 chr1:210001259 C1orf107 -0.44 -5.86 -0.31 1.15e-8 Monobrow; CRC cis rs2179367 0.959 rs480034 chr6:149735430 C/T cg16235748 chr6:149772707 ZC3H12D 0.35 5.72 0.3 2.39e-8 Dupuytren's disease; CRC cis rs62064224 0.546 rs1018866 chr17:30829664 A/C cg18200150 chr17:30822561 MYO1D 0.55 10.79 0.51 1.92e-23 Schizophrenia; CRC cis rs2463822 0.925 rs1528730 chr11:62081181 A/C cg06239285 chr11:62104954 ASRGL1 0.93 10.63 0.51 6.74e-23 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs11255291 1.000 rs7901428 chr10:7732419 C/T cg00997801 chr10:7671259 ITIH5 0.44 6.5 0.34 2.96e-10 Ovarian reserve; CRC cis rs2839186 0.588 rs7280110 chr21:47619039 G/A cg11766577 chr21:47581405 C21orf56 0.4 6.41 0.33 5.03e-10 Testicular germ cell tumor; CRC cis rs853679 0.607 rs201002 chr6:27808192 A/G cg26587870 chr6:27730563 NA -0.65 -6.76 -0.35 6.13e-11 Depression; CRC cis rs2239547 0.603 rs34230854 chr3:53078590 C/A cg18404041 chr3:52824283 ITIH1 -0.34 -5.96 -0.31 6.42e-9 Schizophrenia; CRC cis rs4713118 0.547 rs2116981 chr6:28067951 T/G cg15845792 chr6:28175446 NA 0.99 13.1 0.59 7.48e-32 Parkinson's disease; CRC cis rs2239547 0.522 rs6445550 chr3:52983434 G/A cg18404041 chr3:52824283 ITIH1 -0.37 -6.87 -0.35 3.19e-11 Schizophrenia; CRC cis rs7811142 0.830 rs77861211 chr7:99962096 T/C cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.11 15.96 0.66 7.52e-43 Platelet count; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg05775742 chr12:121022424 NA 0.44 6.25 0.33 1.29e-9 Anxiety disorder; CRC cis rs992157 0.560 rs4674275 chr2:219097738 G/A cg04880052 chr2:219191631 PNKD -0.42 -6.64 -0.34 1.3100000000000001e-10 Colorectal cancer; CRC cis rs17767392 0.813 rs12878989 chr14:71856184 G/A cg13720639 chr14:72061746 SIPA1L1 -0.44 -5.85 -0.31 1.17e-8 Mitral valve prolapse; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg00251738 chr7:77428046 PHTF2;TMEM60 0.49 7.26 0.37 2.73e-12 Intelligence (multi-trait analysis); CRC cis rs875971 0.660 rs10950044 chr7:66042976 A/G cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.43 -6.32 -0.33 8.44e-10 Aortic root size; CRC cis rs9733 0.543 rs72702558 chr1:150683251 G/A cg18016565 chr1:150552671 MCL1 0.45 6.52 0.34 2.57e-10 Tonsillectomy; CRC cis rs2075671 0.810 rs12531792 chr7:100280624 G/A cg20848291 chr7:100343083 ZAN -0.7 -10.27 -0.49 1.2e-21 Other erythrocyte phenotypes; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg18992706 chr13:44453352 CCDC122;C13orf31 0.33 6.36 0.33 6.78e-10 Liver disease severity in Alagille syndrome; CRC cis rs13191362 1.000 rs35044651 chr6:163004142 G/A cg23758597 chr6:163146217 PARK2 -0.55 -6.12 -0.32 2.67e-9 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs12024301 0.557 rs3889890 chr1:183621385 G/T cg11505048 chr1:183622726 RGL1;APOBEC4 0.81 7.0 0.36 1.42e-11 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs7666738 0.830 rs4699603 chr4:99056172 T/C cg17366294 chr4:99064904 C4orf37 0.46 7.72 0.39 1.4e-13 Colonoscopy-negative controls vs population controls; CRC trans rs2055729 0.601 rs12546952 chr8:9744002 G/C cg08975724 chr8:8085496 FLJ10661 -0.48 -6.11 -0.32 2.78e-9 Multiple myeloma (hyperdiploidy); CRC cis rs10504229 0.683 rs7000349 chr8:58114569 C/A cg21724239 chr8:58056113 NA 0.49 6.77 0.35 5.94e-11 Developmental language disorder (linguistic errors); CRC cis rs10927875 1.000 rs4307563 chr1:16313788 C/T cg21385522 chr1:16154831 NA -0.69 -8.71 -0.43 1.54e-16 Dilated cardiomyopathy; CRC cis rs35110281 0.807 rs6518301 chr21:45016818 T/C cg04455712 chr21:45112962 RRP1B 0.4 7.58 0.39 3.45e-13 Mean corpuscular volume; CRC cis rs12597458 0.763 rs7195958 chr16:72036577 A/G cg01557791 chr16:72042693 DHODH 0.64 10.08 0.49 5.26e-21 Prostate cancer; CRC cis rs7715806 0.500 rs4703676 chr5:74979866 G/C cg19683494 chr5:74908142 NA 0.55 6.16 0.32 2.1e-9 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC trans rs12599106 0.648 rs12447240 chr16:34928236 C/T cg15383120 chr6:291909 DUSP22 0.59 8.33 0.42 2.14e-15 Menopause (age at onset); CRC cis rs10870270 1.000 rs10159943 chr10:133744744 T/C cg08754478 chr10:133766260 PPP2R2D -0.67 -9.63 -0.47 1.75e-19 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; CRC cis rs11122272 0.701 rs2011383 chr1:231479788 T/A cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.55 -8.2 -0.41 5.35e-15 Hemoglobin concentration; CRC cis rs9858542 0.953 rs3811699 chr3:49396360 T/C cg03060546 chr3:49711283 APEH -0.48 -6.85 -0.35 3.71e-11 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs4743820 0.620 rs10991787 chr9:93917218 A/G cg14446406 chr9:93919335 NA 0.77 13.47 0.6 2.94e-33 Ulcerative colitis;Inflammatory bowel disease; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg12578567 chr10:69835225 HERC4 0.48 6.82 0.35 4.38e-11 Response to antipsychotic treatment; CRC cis rs7119 0.717 rs12917175 chr15:77818193 A/G cg27398640 chr15:77910606 LINGO1 -0.43 -7.36 -0.38 1.51e-12 Type 2 diabetes; CRC cis rs9322193 0.962 rs12175575 chr6:150084487 G/A cg05861140 chr6:150128134 PCMT1 -0.44 -7.18 -0.37 4.53e-12 Lung cancer; CRC cis rs644799 0.710 rs12273579 chr11:95524421 G/A cg03916912 chr11:95522834 CEP57;FAM76B 0.85 15.84 0.66 2.15e-42 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs3617 0.625 rs7617468 chr3:52849549 T/C cg18099408 chr3:52552593 STAB1 -0.35 -5.92 -0.31 8.13e-9 Red blood cell count;Autism spectrum disorder or schizophrenia; CRC cis rs2836974 0.644 rs61300849 chr21:40680194 G/A cg11644478 chr21:40555479 PSMG1 -0.68 -10.99 -0.52 3.75e-24 Cognitive function; CRC cis rs9467603 0.925 rs4712969 chr6:25764192 A/G cg08501292 chr6:25962987 TRIM38 -0.88 -8.33 -0.42 2.16e-15 Intelligence (multi-trait analysis); CRC cis rs6570726 0.967 rs7772286 chr6:145930423 A/T cg05347473 chr6:146136440 FBXO30 -0.38 -5.85 -0.31 1.17e-8 Lobe attachment (rater-scored or self-reported); CRC cis rs6931421 0.800 rs12662365 chr6:80905389 T/A cg08355045 chr6:80787529 NA 0.47 7.44 0.38 8.79e-13 Sitting height ratio; CRC cis rs9491140 0.539 rs10872285 chr6:124689145 C/T cg19267163 chr6:125004984 NKAIN2 0.53 6.85 0.35 3.61e-11 Neuroticism; CRC cis rs9443645 0.901 rs2050663 chr6:79753394 T/C cg05283184 chr6:79620031 NA -0.62 -9.71 -0.47 9.33e-20 Intelligence (multi-trait analysis); CRC cis rs2832191 0.755 rs55671430 chr21:30492421 G/C cg08807101 chr21:30365312 RNF160 -0.63 -9.93 -0.48 1.74e-20 Dental caries; CRC cis rs1552244 0.572 rs6442154 chr3:10168785 A/G cg13047869 chr3:10149882 C3orf24 0.54 6.49 0.34 3.1e-10 Alzheimer's disease; CRC cis rs2839186 0.900 rs2839200 chr21:47709095 C/T cg09417038 chr21:47716443 C21orf57 -0.42 -6.9 -0.36 2.66e-11 Testicular germ cell tumor; CRC cis rs17826219 0.636 rs79565452 chr17:29142841 T/C cg01831904 chr17:28903510 LRRC37B2 -0.63 -6.5 -0.34 3.04e-10 Body mass index; CRC cis rs11190604 1.000 rs74650218 chr10:102293830 C/T cg07080220 chr10:102295463 HIF1AN 0.47 5.65 0.3 3.39e-8 Palmitoleic acid (16:1n-7) levels; CRC cis rs2084898 0.527 rs605374 chr11:120005633 A/C cg16005559 chr11:120040616 NA -0.45 -6.36 -0.33 6.61e-10 Stroke (pediatric); CRC cis rs12711979 0.740 rs6711964 chr2:3820916 A/T cg17052675 chr2:3827356 NA -0.57 -10.83 -0.51 1.38e-23 Itch intensity from mosquito bite adjusted by bite size; CRC cis rs9467711 0.659 rs36162392 chr6:26569135 T/C cg08501292 chr6:25962987 TRIM38 0.89 6.15 0.32 2.3e-9 Autism spectrum disorder or schizophrenia; CRC cis rs9467711 0.606 rs35076545 chr6:26603924 C/A cg16898833 chr6:26189333 HIST1H4D 1.14 8.46 0.42 8.89e-16 Autism spectrum disorder or schizophrenia; CRC cis rs4713118 0.824 rs9366702 chr6:27734470 T/C cg25164649 chr6:28176230 NA 0.6 7.91 0.4 4.06e-14 Parkinson's disease; CRC cis rs6952808 1.000 rs4721122 chr7:1893311 C/G cg04267008 chr7:1944627 MAD1L1 -0.68 -9.96 -0.48 1.3e-20 Bipolar disorder and schizophrenia; CRC cis rs9682041 0.696 rs6786542 chr3:170105378 C/T cg11886554 chr3:170076028 SKIL 0.7 8.29 0.42 2.98e-15 Glomerular filtration rate in non diabetics (creatinine);Glomerular filtration rate (creatinine); CRC cis rs10751667 0.666 rs10902247 chr11:953686 G/A ch.11.42038R chr11:967971 AP2A2 0.57 9.75 0.47 6.98e-20 Alzheimer's disease (late onset); CRC cis rs9435341 0.930 rs2232015 chr1:107599258 A/T cg14671364 chr1:107599128 PRMT6 0.62 8.45 0.42 9.23e-16 Facial morphology (factor 21, depth of nasal alae); CRC cis rs8060686 0.565 rs75286242 chr16:68145798 C/T cg26727032 chr16:67993705 SLC12A4 -0.56 -6.35 -0.33 7.33e-10 HDL cholesterol;Metabolic syndrome; CRC cis rs56399783 0.803 rs17132665 chr7:2802173 T/C cg19731401 chr7:2775893 GNA12 0.64 7.2 0.37 4.02e-12 Childhood ear infection; CRC cis rs2795502 1.000 rs2796575 chr10:43374911 A/G cg20628663 chr10:43360327 NA 0.7 10.97 0.52 4.62e-24 Blood protein levels; CRC cis rs13418455 0.619 rs1518709 chr2:181230398 A/G cg23363182 chr2:181467187 NA -0.39 -5.72 -0.3 2.4e-8 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC trans rs8002861 0.875 rs11616803 chr13:44457109 A/G cg17145862 chr1:211918768 LPGAT1 -0.73 -13.35 -0.59 9.02e-33 Leprosy; CRC cis rs7617773 0.743 rs7621785 chr3:48343708 T/C cg11946769 chr3:48343235 NME6 0.72 9.63 0.47 1.74e-19 Coronary artery disease; CRC cis rs6968419 0.755 rs6966770 chr7:115895718 A/G cg02561103 chr7:115862891 TES -0.37 -5.75 -0.3 1.99e-8 Intraocular pressure; CRC cis rs4434138 0.594 rs7653028 chr3:52763000 A/T cg10802521 chr3:52805072 NEK4 -0.55 -8.72 -0.43 1.44e-16 Intelligence (multi-trait analysis); CRC cis rs7739232 0.850 rs76135039 chr6:53529138 C/T cg15658676 chr6:53530538 KLHL31 -0.76 -5.9 -0.31 8.9e-9 Hip circumference adjusted for BMI; CRC cis rs13108904 0.967 rs900027 chr4:1279360 G/A cg05665937 chr4:1216051 CTBP1 0.4 5.73 0.3 2.32e-8 Obesity-related traits; CRC cis rs67981189 0.529 rs17108862 chr14:71464666 G/A cg15910301 chr14:71632612 NA 0.29 5.79 0.3 1.63e-8 Schizophrenia; CRC cis rs7618915 0.547 rs2268026 chr3:52778347 T/C cg08222913 chr3:52553049 STAB1 -0.34 -6.15 -0.32 2.29e-9 Bipolar disorder; CRC cis rs3996993 0.573 rs10948726 chr6:52695461 G/T cg20803780 chr6:52668592 GSTA1 0.4 6.71 0.35 8.57e-11 Hemoglobin concentration; CRC trans rs5756813 0.754 rs4821708 chr22:38164106 C/T cg19894588 chr14:64061835 NA -0.58 -8.09 -0.41 1.15e-14 Optic cup area;Vertical cup-disc ratio; CRC cis rs4665809 0.590 rs35615763 chr2:26468778 C/G cg04944784 chr2:26401820 FAM59B 0.83 10.74 0.51 2.96e-23 Gut microbiome composition (summer); CRC cis rs4984778 0.750 rs7198064 chr16:1272472 C/T cg09075268 chr16:1270372 CACNA1H 0.4 6.1 0.32 2.9e-9 Blood protein levels; CRC cis rs8031584 0.958 rs8034856 chr15:31240957 T/C cg08704250 chr15:31115839 NA -0.43 -7.9 -0.4 4.19e-14 Huntington's disease progression; CRC trans rs617791 0.530 rs7952056 chr11:65744597 C/T cg17712092 chr4:129076599 LARP1B -0.46 -6.7 -0.35 8.88e-11 Breast cancer; CRC cis rs524281 0.954 rs549187 chr11:65898631 C/T cg14036092 chr11:66035641 RAB1B -0.49 -6.78 -0.35 5.59e-11 Electroencephalogram traits; CRC cis rs2153535 0.601 rs9406160 chr6:8464907 A/C cg21535247 chr6:8435926 SLC35B3 0.5 7.51 0.38 5.79e-13 Motion sickness; CRC cis rs35264875 1.000 rs72928652 chr11:68851547 G/A cg15234197 chr11:68924956 NA 0.44 6.12 0.32 2.72e-9 Blond vs. brown hair color; CRC cis rs9916302 0.904 rs679995 chr17:37441679 A/T cg00129232 chr17:37814104 STARD3 0.54 7.9 0.4 4.31e-14 Glomerular filtration rate (creatinine); CRC cis rs933688 0.938 rs1477348 chr5:90707823 G/A cg26981201 chr5:90679533 LOC100129716;ARRDC3 1.02 15.59 0.65 1.97e-41 Smoking behavior; CRC cis rs9902453 0.765 rs3115087 chr17:28030267 G/C cg26525008 chr17:28256777 EFCAB5;SSH2 0.62 9.57 0.47 2.57e-19 Coffee consumption (cups per day); CRC cis rs9487051 1.000 rs9386795 chr6:109616528 G/A cg21918786 chr6:109611834 NA -0.38 -6.47 -0.34 3.53e-10 Reticulocyte fraction of red cells; CRC cis rs12580194 0.593 rs67015069 chr12:55759968 T/A cg19537932 chr12:55886519 OR6C68 -0.73 -9.19 -0.45 4.43e-18 Cancer; CRC trans rs1814175 0.754 rs28663627 chr11:50048829 C/T cg03929089 chr4:120376271 NA -0.95 -19.09 -0.72 3.22e-55 Height; CRC cis rs3806843 0.576 rs265316 chr5:140290843 T/C cg19875535 chr5:140030758 IK 0.46 6.98 0.36 1.59e-11 Depressive symptoms (multi-trait analysis); CRC cis rs10504229 0.679 rs72649109 chr8:58031274 A/T cg02725872 chr8:58115012 NA -0.51 -7.11 -0.36 7.24e-12 Developmental language disorder (linguistic errors); CRC cis rs798554 0.959 rs798557 chr7:2758982 G/A cg04166393 chr7:2884313 GNA12 0.45 6.03 0.32 4.46e-9 Height; CRC cis rs8105895 0.799 rs6511327 chr19:22286899 T/A cg02657401 chr19:22469223 NA -0.36 -5.85 -0.31 1.18e-8 Body mass index (change over time); CRC cis rs7493 1.000 rs12155103 chr7:95037131 G/A cg01874867 chr7:94954059 PON1 -0.49 -6.36 -0.33 6.6e-10 Yu-Zhi constitution type in type 2 diabetes; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg09011732 chr2:74730507 LOC151534;LBX2 0.45 7.03 0.36 1.16e-11 Liver disease severity in Alagille syndrome; CRC cis rs9527 0.615 rs7096452 chr10:104736563 G/A cg04362960 chr10:104952993 NT5C2 0.59 8.46 0.42 9.13e-16 Arsenic metabolism; CRC cis rs10504229 0.679 rs75402323 chr8:58136227 A/G cg22535103 chr8:58192502 C8orf71 -0.7 -9.34 -0.46 1.47e-18 Developmental language disorder (linguistic errors); CRC cis rs9875589 0.509 rs2731337 chr3:14091440 G/C cg14375111 chr3:14165186 TMEM43;CHCHD4 0.41 6.01 0.31 4.88e-9 Ovarian reserve; CRC cis rs9534288 0.912 rs3736944 chr13:46619316 T/C cg15192986 chr13:46630673 CPB2 -0.74 -10.36 -0.5 5.94e-22 Blood protein levels; CRC cis rs4819052 0.808 rs2838825 chr21:46655651 C/T cg19498844 chr21:46707878 POFUT2;LOC642852 0.73 9.8 0.48 4.69e-20 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs4713118 0.699 rs200978 chr6:27853168 C/G cg12172441 chr6:28176163 NA 0.51 6.26 0.33 1.23e-9 Parkinson's disease; CRC cis rs4819052 0.851 rs8127834 chr21:46696109 G/A cg02159808 chr21:46707872 POFUT2;LOC642852 0.53 6.97 0.36 1.78e-11 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs10504229 1.000 rs6987435 chr8:58177334 G/A cg02290350 chr8:58132656 NA -0.42 -5.96 -0.31 6.39e-9 Developmental language disorder (linguistic errors); CRC cis rs908922 0.676 rs1337340 chr1:152508260 T/C cg23254163 chr1:152506842 NA 0.47 9.15 0.45 6.23e-18 Hair morphology; CRC cis rs11748023 0.605 rs152409 chr5:139521808 T/C cg26211634 chr5:139558579 C5orf32 0.36 6.1 0.32 2.98e-9 Intelligence (multi-trait analysis); CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg16904090 chr1:40997253 ZNF684 0.49 6.37 0.33 6.25e-10 Thyroid stimulating hormone; CRC cis rs989128 0.600 rs9913677 chr17:48628581 T/A cg16068336 chr17:48637367 CACNA1G -0.51 -7.49 -0.38 6.44e-13 Type 2 diabetes; CRC cis rs10197940 0.578 rs6718653 chr2:152346118 C/A cg06191203 chr2:152266755 RIF1 -0.46 -6.52 -0.34 2.71e-10 Lung cancer; CRC cis rs10504229 0.813 rs6999878 chr8:58197243 C/G cg24829409 chr8:58192753 C8orf71 -0.54 -8.06 -0.41 1.42e-14 Developmental language disorder (linguistic errors); CRC cis rs8014204 0.836 rs7154256 chr14:75252587 A/G cg03030879 chr14:75389066 RPS6KL1 -0.5 -8.16 -0.41 7.25e-15 Caffeine consumption; CRC trans rs1997103 0.798 rs12154964 chr7:55414041 G/A cg20935933 chr6:143382018 AIG1 0.5 6.46 0.34 3.8e-10 QRS interval (sulfonylurea treatment interaction); CRC cis rs968567 0.539 rs174556 chr11:61580635 C/T cg06781209 chr11:61594997 FADS2 -0.42 -5.99 -0.31 5.58e-9 Blood metabolite levels;Rheumatoid arthritis;Vitiligo;Glycerophospholipid levels; CRC cis rs769267 0.895 rs2965189 chr19:19519518 G/T cg03709012 chr19:19516395 GATAD2A 0.72 11.37 0.53 1.76e-25 Tonsillectomy; CRC cis rs6570726 0.764 rs451108 chr6:145844309 T/C cg05347473 chr6:146136440 FBXO30 0.4 6.24 0.33 1.37e-9 Lobe attachment (rater-scored or self-reported); CRC trans rs1814175 0.817 rs1794162 chr11:49899506 A/C cg03929089 chr4:120376271 NA -0.98 -19.25 -0.73 7.43e-56 Height; CRC trans rs9291683 0.632 rs7679916 chr4:10042160 C/T cg26043149 chr18:55253948 FECH 0.53 8.17 0.41 6.79e-15 Bone mineral density; CRC cis rs7208859 0.673 rs2269916 chr17:29233763 A/G cg13385521 chr17:29058706 SUZ12P 0.69 7.93 0.4 3.48e-14 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC trans rs925098 0.577 rs2724470 chr4:17996046 A/G cg17720231 chr1:159915374 IGSF9 -0.4 -5.97 -0.31 6.19e-9 Birth weight;Height; CRC cis rs7789940 1.000 rs11765693 chr7:75985373 A/G cg10167463 chr7:75959203 YWHAG -0.78 -11.32 -0.53 2.53e-25 Multiple sclerosis; CRC cis rs10924970 0.967 rs8179454 chr1:235460719 C/G cg26050004 chr1:235667680 B3GALNT2 0.4 6.02 0.32 4.63e-9 Asthma; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg02432107 chr7:102105641 ALKBH4;LRWD1 0.38 6.23 0.32 1.46e-9 Liver disease severity in Alagille syndrome; CRC cis rs754466 0.651 rs10762767 chr10:79645070 C/A cg17075019 chr10:79541650 NA -0.88 -15.07 -0.64 2.15e-39 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs362272 0.524 rs10937924 chr4:3374898 T/C cg08741688 chr4:3415352 RGS12 -0.45 -6.65 -0.34 1.19e-10 Serum sulfate level; CRC cis rs10504229 0.861 rs57942497 chr8:58171239 G/T cg24829409 chr8:58192753 C8orf71 -0.68 -11.34 -0.53 2.27e-25 Developmental language disorder (linguistic errors); CRC cis rs13144136 0.687 rs7677121 chr4:10654107 G/T cg10242279 chr4:10666415 CLNK -0.36 -6.19 -0.32 1.83e-9 Resistance to antihypertensive treatment in hypertension; CRC cis rs9640161 0.659 rs17837498 chr7:150009679 A/G cg12556325 chr7:150026731 C7orf29;LRRC61 -0.42 -6.49 -0.34 3.21e-10 Blood protein levels;Circulating chemerin levels; CRC cis rs6121246 0.909 rs1994249 chr20:30287593 C/T cg07809909 chr20:30433512 FOXS1 0.35 5.7 0.3 2.65e-8 Mean corpuscular hemoglobin; CRC cis rs736408 0.648 rs3774355 chr3:52817778 G/A cg15147215 chr3:52552868 STAB1 -0.59 -9.2 -0.45 4.14e-18 Bipolar disorder; CRC cis rs4954585 0.659 rs4072435 chr2:137013901 C/T cg05194412 chr2:137003533 NA 0.44 6.89 0.35 2.9e-11 Colorectal cancer; CRC trans rs11148252 0.508 rs11148260 chr13:53162643 A/C cg18335740 chr13:41363409 SLC25A15 0.77 14.0 0.61 3.03e-35 Lewy body disease; CRC trans rs7726839 0.574 rs72705014 chr5:619815 C/G cg25482853 chr8:67687455 SGK3 1.1 12.9 0.58 4.37e-31 Obesity-related traits; CRC cis rs7412746 0.658 rs12090215 chr1:150893660 C/A cg17724175 chr1:150552817 MCL1 0.44 6.66 0.34 1.14e-10 Melanoma; CRC cis rs7072216 0.881 rs2274247 chr10:100150148 G/C cg26618903 chr10:100175079 PYROXD2 -0.37 -6.17 -0.32 2.05e-9 Metabolite levels; CRC cis rs7246657 1.000 rs1823061 chr19:37800626 G/A cg23950597 chr19:37808831 NA -0.51 -6.11 -0.32 2.86e-9 Coronary artery calcification; CRC cis rs7703744 0.681 rs11957102 chr5:118701899 G/T cg19893178 chr5:118692011 TNFAIP8 0.44 5.81 0.3 1.5e-8 Lobe attachment (rater-scored or self-reported); CRC cis rs35110281 0.805 rs2838317 chr21:44991791 A/C cg04455712 chr21:45112962 RRP1B 0.4 7.91 0.4 4.03e-14 Mean corpuscular volume; CRC cis rs7762018 0.941 rs4716384 chr6:170109184 T/A cg24289452 chr6:170231220 NA -0.6 -6.58 -0.34 1.89e-10 Thiazide-induced adverse metabolic effects in hypertensive patients; CRC cis rs6088813 1.000 rs6142379 chr20:33999267 A/G cg14752227 chr20:34000481 UQCC -0.37 -5.64 -0.3 3.7e-8 Height; CRC cis rs2692947 0.770 rs2315421 chr2:96497516 G/C cg23100626 chr2:96804247 ASTL 0.26 6.86 0.35 3.42e-11 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; CRC cis rs9826463 0.702 rs55994893 chr3:142304694 G/C cg20824294 chr3:142316082 PLS1 0.42 6.84 0.35 3.86e-11 QRS duration in Tripanosoma cruzi seropositivity; CRC trans rs8002861 0.967 rs9533691 chr13:44482208 A/G cg17145862 chr1:211918768 LPGAT1 0.77 15.68 0.65 9.39e-42 Leprosy; CRC cis rs9911578 0.933 rs2531726 chr17:56522533 C/T cg05425664 chr17:57184151 TRIM37 0.51 7.87 0.4 5.19e-14 Intelligence (multi-trait analysis); CRC cis rs1065852 0.526 rs9623489 chr22:42397026 A/G cg00645731 chr22:42541494 CYP2D7P1 0.4 6.85 0.35 3.59e-11 Response to serotonin reuptake inhibitors in major depressive disorder (plasma drug and metabolite levels); CRC cis rs11122272 0.735 rs10489611 chr1:231517854 A/T cg06096015 chr1:231504339 EGLN1 0.4 5.94 0.31 7.17e-9 Hemoglobin concentration; CRC cis rs2346177 1.000 rs11125074 chr2:46655260 G/A cg26688816 chr2:46740690 ATP6V1E2 -0.52 -8.2 -0.41 5.4e-15 HDL cholesterol; CRC cis rs868943 0.582 rs12196141 chr6:116489550 C/T cg15226275 chr6:116381976 FRK -0.26 -5.87 -0.31 1.05e-8 Total cholesterol levels; CRC trans rs1814175 0.645 rs28627251 chr11:50048125 G/T cg11707556 chr5:10655725 ANKRD33B -0.5 -9.83 -0.48 3.72e-20 Height; CRC cis rs7917772 0.503 rs11191321 chr10:104293412 C/T cg11453585 chr10:104263688 ACTR1A;SUFU 0.9 16.75 0.68 5.87e-46 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC cis rs7772486 0.790 rs6923545 chr6:146244743 A/G cg23711669 chr6:146136114 FBXO30 -0.72 -12.76 -0.58 1.48e-30 Lobe attachment (rater-scored or self-reported); CRC cis rs1552244 1.000 rs55822690 chr3:10128003 A/G cg00166722 chr3:10149974 C3orf24 0.69 9.2 0.45 4.18e-18 Alzheimer's disease; CRC cis rs17384381 1.000 rs71652696 chr1:85831792 A/C cg16011679 chr1:85725395 C1orf52 0.7 7.04 0.36 1.13e-11 Lobe attachment (rater-scored or self-reported); CRC cis rs10876993 0.890 rs810204 chr12:58075733 T/C cg18357645 chr12:58087776 OS9 0.6 8.3 0.42 2.66e-15 Celiac disease or Rheumatoid arthritis; CRC cis rs362272 0.545 rs3135146 chr4:3307638 C/G cg11522145 chr4:3412961 RGS12 0.36 5.74 0.3 2.12e-8 Serum sulfate level; CRC trans rs208520 0.690 rs207081 chr6:66773742 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.04 -14.63 -0.63 1.07e-37 Exhaled nitric oxide output; CRC cis rs6662572 0.737 rs10890356 chr1:46317924 A/G cg08644498 chr1:46502608 NA -0.45 -7.07 -0.36 9.42e-12 Blood protein levels; CRC cis rs10504229 0.953 rs59265461 chr8:58189701 A/T cg02725872 chr8:58115012 NA -0.38 -6.43 -0.33 4.44e-10 Developmental language disorder (linguistic errors); CRC cis rs926938 0.527 rs58658580 chr1:115539726 A/G cg12756093 chr1:115239321 AMPD1 0.48 7.01 0.36 1.34e-11 Autism; CRC cis rs2522056 1.000 rs2106854 chr5:131769174 C/T cg20512303 chr5:131592959 PDLIM4 -0.35 -5.66 -0.3 3.3e-8 Lymphocyte counts;Fibrinogen; CRC cis rs1008375 1.000 rs1558377 chr4:17650758 A/G cg04450456 chr4:17643702 FAM184B 0.37 5.88 0.31 9.91e-9 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs875971 0.658 rs432667 chr7:65514633 A/G cg18876405 chr7:65276391 NA 0.51 8.77 0.44 9.53e-17 Aortic root size; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg15057440 chr2:74685383 WBP1 0.43 6.02 0.31 4.64e-9 Response to antipsychotic treatment; CRC cis rs8177253 0.761 rs1830083 chr3:133508551 G/A cg12373951 chr3:133503437 NA 0.27 6.99 0.36 1.58e-11 Iron status biomarkers; CRC cis rs4290604 0.679 rs73083545 chr2:237983894 C/G cg23555395 chr2:238036564 NA 0.54 7.03 0.36 1.2e-11 Asthma; CRC cis rs6754311 0.550 rs12994270 chr2:136518103 T/A cg15123519 chr2:136567270 LCT 0.3 5.65 0.3 3.46e-8 Mosquito bite size; CRC cis rs9486719 1.000 rs12201449 chr6:96959382 C/T cg18709589 chr6:96969512 KIAA0776 -0.51 -5.72 -0.3 2.43e-8 Migraine;Coronary artery disease; CRC cis rs2354432 0.599 rs6693667 chr1:146817245 A/T cg25205988 chr1:146714368 CHD1L 0.95 9.37 0.46 1.19e-18 Mitochondrial DNA levels; CRC cis rs801193 0.591 rs4506088 chr7:66135457 G/A cg18876405 chr7:65276391 NA -0.5 -8.03 -0.4 1.74e-14 Aortic root size; CRC cis rs7209700 0.963 rs1000232 chr17:45356561 T/C cg08085267 chr17:45401833 C17orf57 0.48 7.05 0.36 1.05e-11 IgG glycosylation; CRC cis rs9733 0.596 rs11582840 chr1:150688487 A/G cg15448220 chr1:150897856 SETDB1 0.45 6.41 0.33 5.09e-10 Tonsillectomy; CRC cis rs2842992 0.915 rs2842985 chr6:160085434 C/T cg11366901 chr6:160182831 ACAT2 0.98 13.11 0.59 6.89e-32 Age-related macular degeneration (geographic atrophy); CRC cis rs2032447 0.839 rs9356995 chr6:25996673 G/A cg17691542 chr6:26056736 HIST1H1C 0.42 5.84 0.31 1.25e-8 Intelligence (multi-trait analysis); CRC cis rs9457247 0.663 rs9457257 chr6:167440736 G/A cg07741184 chr6:167504864 NA 0.36 6.38 0.33 6.18e-10 Crohn's disease; CRC cis rs694739 0.726 rs17857342 chr11:64138905 T/G cg23796481 chr11:64053134 BAD;GPR137 0.47 6.57 0.34 1.99e-10 Alopecia areata;Crohn's disease;Psoriasis vulgaris; CRC cis rs7113874 0.569 rs4929942 chr11:8625096 A/G cg02811074 chr11:8615871 STK33 0.35 5.98 0.31 5.83e-9 Body mass index in physically active individuals;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs7666738 0.830 rs13138438 chr4:99050545 C/A cg17366294 chr4:99064904 C4orf37 0.45 7.75 0.39 1.16e-13 Colonoscopy-negative controls vs population controls; CRC cis rs7937682 0.587 rs611607 chr11:111349765 C/T cg19812747 chr11:111475976 SIK2 -0.44 -6.99 -0.36 1.49e-11 Primary sclerosing cholangitis; CRC cis rs806215 1.000 rs2106187 chr7:127241353 C/T cg25922125 chr7:127225783 GCC1 0.58 6.37 0.33 6.52e-10 Type 2 diabetes; CRC cis rs9443645 0.901 rs4706079 chr6:79615208 G/A cg09184832 chr6:79620586 NA -0.51 -9.58 -0.47 2.53e-19 Intelligence (multi-trait analysis); CRC cis rs1801251 1.000 rs895430 chr2:233725483 C/A cg25237894 chr2:233734115 C2orf82 -0.52 -8.35 -0.42 1.86e-15 Coronary artery disease; CRC cis rs58688157 0.705 rs7112149 chr11:595890 G/A cg02461776 chr11:598696 PHRF1 0.46 5.86 0.31 1.14e-8 Systemic lupus erythematosus; CRC cis rs2380220 0.606 rs4571572 chr6:96004823 T/C cg04719120 chr6:96025338 MANEA 0.6 7.9 0.4 4.36e-14 Behavioural disinhibition (generation interaction); CRC cis rs79387448 0.745 rs72993722 chr2:103124916 A/G cg09003973 chr2:102972529 NA 0.68 7.54 0.38 4.74e-13 Gut microbiota (bacterial taxa); CRC cis rs28386778 0.805 rs9911714 chr17:61828952 G/A cg22520471 chr17:61851767 DDX42;CCDC47 0.74 11.54 0.54 4.32e-26 Prudent dietary pattern; CRC cis rs9325144 0.555 rs61929925 chr12:38698828 C/A cg26384229 chr12:38710491 ALG10B -0.58 -8.52 -0.43 5.97e-16 Morning vs. evening chronotype; CRC cis rs6952808 0.531 rs4721441 chr7:2184060 A/G cg02951883 chr7:2050386 MAD1L1 -0.59 -9.19 -0.45 4.68e-18 Bipolar disorder and schizophrenia; CRC trans rs1814175 0.645 rs1874969 chr11:49826700 G/A cg21153622 chr11:89784906 NA -0.4 -6.24 -0.33 1.34e-9 Height; CRC cis rs798554 0.757 rs2533879 chr7:2859847 G/A cg19717773 chr7:2847554 GNA12 -0.49 -6.94 -0.36 2.1e-11 Height; CRC cis rs6424115 0.830 rs6663474 chr1:24199642 G/A cg09473613 chr1:24152604 HMGCL 0.35 5.67 0.3 3.16e-8 Immature fraction of reticulocytes; CRC cis rs9534288 0.762 rs9534285 chr13:46601902 T/C cg15192986 chr13:46630673 CPB2 -0.67 -9.87 -0.48 2.77e-20 Blood protein levels; CRC cis rs8005677 1.000 rs1956881 chr14:23394069 A/C cg25600027 chr14:23388339 RBM23 -0.53 -8.3 -0.42 2.69e-15 Cognitive ability (multi-trait analysis); CRC cis rs9341808 0.667 rs6938280 chr6:80897782 G/A cg08355045 chr6:80787529 NA 0.34 5.86 0.31 1.1e-8 Sitting height ratio; CRC cis rs4888262 0.526 rs7205992 chr16:74590578 T/A cg01733217 chr16:74700730 RFWD3 0.74 11.15 0.52 1.08e-24 Testicular germ cell tumor; CRC cis rs6502050 0.835 rs4789678 chr17:80101078 C/T cg09264619 chr17:80180166 NA -0.36 -6.17 -0.32 2.04e-9 Life satisfaction; CRC trans rs11825064 0.636 rs67824656 chr11:134485625 T/G cg00033773 chr19:12779366 MORG1;C19orf56 0.45 6.17 0.32 1.97e-9 Seasonality; CRC cis rs3772130 1.000 rs13083794 chr3:121464928 T/G cg20356878 chr3:121714668 ILDR1 0.51 7.75 0.39 1.19e-13 Cognitive performance; CRC cis rs7772486 0.712 rs1292335 chr6:145967877 G/T cg05347473 chr6:146136440 FBXO30 0.37 5.65 0.3 3.39e-8 Lobe attachment (rater-scored or self-reported); CRC cis rs597539 0.690 rs7129960 chr11:68622456 A/G cg06028808 chr11:68637592 NA 0.4 6.19 0.32 1.79e-9 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs7618501 0.633 rs9853222 chr3:50022926 T/C cg24308560 chr3:49941425 MST1R -0.51 -8.26 -0.41 3.53e-15 Intelligence (multi-trait analysis); CRC cis rs11123170 0.640 rs2863240 chr2:113970116 C/T cg07772999 chr2:113993052 PAX8;LOC440839;LOC654433 -0.47 -6.18 -0.32 1.93e-9 Renal function-related traits (BUN); CRC cis rs7666738 0.830 rs11727235 chr4:98946331 T/C cg17366294 chr4:99064904 C4orf37 0.43 7.34 0.38 1.69e-12 Colonoscopy-negative controls vs population controls; CRC cis rs10924970 0.534 rs10925362 chr1:235464380 G/A cg09010748 chr1:235293032 TOMM20 -0.43 -5.92 -0.31 8.25e-9 Asthma; CRC trans rs7618501 0.633 rs9866695 chr3:50069452 G/T cg21659725 chr3:3221576 CRBN -0.61 -9.7 -0.47 9.86e-20 Intelligence (multi-trait analysis); CRC cis rs1448094 0.556 rs11610627 chr12:86167752 C/T cg00310523 chr12:86230176 RASSF9 0.4 6.52 0.34 2.6200000000000003e-10 Major depressive disorder; CRC cis rs12142240 0.698 rs7515284 chr1:46809419 A/G cg00530320 chr1:46809349 NSUN4 0.58 7.98 0.4 2.46e-14 Menopause (age at onset); CRC cis rs9311474 0.607 rs28661185 chr3:52567188 G/T cg10802521 chr3:52805072 NEK4 -0.53 -8.37 -0.42 1.72e-15 Electroencephalogram traits; CRC cis rs780096 0.506 rs1262430 chr2:27673798 T/C cg21248554 chr2:27665150 KRTCAP3 -0.34 -7.86 -0.4 5.35e-14 Total body bone mineral density; CRC cis rs9287719 0.967 rs10167129 chr2:10758575 G/A cg00105475 chr2:10696890 NA 0.44 7.14 0.37 6.13e-12 Prostate cancer; CRC trans rs3780486 0.846 rs10813948 chr9:33121570 G/A cg20290983 chr6:43655470 MRPS18A 1.14 25.81 0.82 4.42e-81 IgG glycosylation; CRC cis rs9467711 0.606 rs35307327 chr6:26370474 C/T cg16898833 chr6:26189333 HIST1H4D 0.76 6.58 0.34 1.88e-10 Autism spectrum disorder or schizophrenia; CRC cis rs7666738 0.830 rs921522 chr4:98841608 C/T cg05340658 chr4:99064831 C4orf37 0.57 8.32 0.42 2.38e-15 Colonoscopy-negative controls vs population controls; CRC cis rs17092148 0.945 rs6142237 chr20:33340993 C/T cg08999081 chr20:33150536 PIGU 0.46 5.68 0.3 2.89e-8 Neuroticism; CRC cis rs10751667 0.643 rs11246344 chr11:933783 A/C cg06064525 chr11:970664 AP2A2 -0.34 -6.75 -0.35 6.62e-11 Alzheimer's disease (late onset); CRC trans rs684232 0.666 rs461521 chr17:622497 G/T cg22807402 chr17:73269154 SLC25A19 -0.34 -6.02 -0.31 4.57e-9 Prostate cancer; CRC trans rs4378999 0.660 rs9824522 chr3:50771992 C/T cg12383621 chr7:7735611 RPA3 -0.48 -6.02 -0.31 4.74e-9 Waist circumference adjusted for BMI in non-smokers;Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction); CRC cis rs6831352 0.703 rs3133152 chr4:100031721 C/G cg12011299 chr4:100065546 ADH4 0.45 8.75 0.43 1.1e-16 Alcohol dependence; CRC cis rs1008375 1.000 rs4698199 chr4:17656738 G/C cg16339924 chr4:17578868 LAP3 0.59 8.0 0.4 2.12e-14 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs9457247 0.612 rs2237273 chr6:167443017 T/C cg07741184 chr6:167504864 NA 0.35 6.23 0.32 1.4e-9 Crohn's disease; CRC cis rs12325245 0.536 rs17821543 chr16:58540875 C/T cg01472538 chr16:58549086 SETD6 1.1 7.06 0.36 1.01e-11 Schizophrenia; CRC cis rs9322817 0.583 rs7746856 chr6:105146360 A/C cg02098413 chr6:105308735 HACE1 0.43 8.19 0.41 5.71e-15 Thyroid stimulating hormone; CRC trans rs4263408 0.934 rs9683743 chr4:39703194 A/C cg02873525 chr19:48675305 NA -0.4 -6.02 -0.31 4.74e-9 Plasma amyloid beta peptide concentrations (ABx-40); CRC cis rs365302 1.000 rs2245986 chr6:159648661 G/A cg14500486 chr6:159655392 FNDC1 0.44 6.82 0.35 4.31e-11 Coronary heart disease; CRC cis rs17155006 0.621 rs436573 chr7:107739906 A/T cg05962710 chr7:107745446 LAMB4 -0.37 -6.73 -0.35 7.54e-11 Pneumococcal bacteremia; CRC cis rs7927592 0.956 rs7113287 chr11:68372186 A/T cg01657329 chr11:68192670 LRP5 -0.51 -7.98 -0.4 2.53e-14 Total body bone mineral density; CRC cis rs853679 0.517 rs3173443 chr6:28137027 T/G cg12172441 chr6:28176163 NA 0.64 7.53 0.38 5.03e-13 Depression; CRC cis rs600806 0.815 rs4970754 chr1:109969721 A/G cg23032129 chr1:109941072 SORT1 -0.29 -6.08 -0.32 3.28e-9 Intelligence (multi-trait analysis); CRC cis rs1448094 0.817 rs12370270 chr12:86343303 T/G cg18827107 chr12:86230957 RASSF9 -0.42 -6.68 -0.35 9.97e-11 Major depressive disorder; CRC cis rs6461049 0.638 rs1859993 chr7:2183702 A/G cg21782813 chr7:2030301 MAD1L1 0.4 7.33 0.37 1.8e-12 Schizophrenia; CRC cis rs13108904 0.901 rs1680073 chr4:1280337 G/A cg16405210 chr4:1374714 KIAA1530 0.44 6.5 0.34 3.01e-10 Obesity-related traits; CRC cis rs9640161 0.789 rs2159234 chr7:150020422 A/T cg12556325 chr7:150026731 C7orf29;LRRC61 -0.44 -6.49 -0.34 3.17e-10 Blood protein levels;Circulating chemerin levels; CRC cis rs5769765 0.773 rs9616395 chr22:50317803 A/G cg02269571 chr22:50332266 NA -0.68 -8.29 -0.42 2.91e-15 Schizophrenia; CRC cis rs7635838 0.654 rs164101 chr3:11281082 G/A cg00170343 chr3:11313890 ATG7 0.56 8.33 0.42 2.28e-15 HDL cholesterol; CRC cis rs7786808 0.741 rs11765319 chr7:158226790 A/G cg15440763 chr7:158190612 PTPRN2 0.36 5.73 0.3 2.26e-8 Obesity-related traits; CRC cis rs875971 0.895 rs1833495 chr7:65921595 T/C cg00343986 chr7:65444356 GUSB 0.43 6.29 0.33 1.03e-9 Aortic root size; CRC cis rs1868673 1.000 rs9813752 chr3:150151120 G/A cg04908077 chr3:150187338 NA -0.33 -5.65 -0.3 3.49e-8 Waist circumference; CRC cis rs7552404 0.731 rs12090849 chr1:76400261 A/G cg03433033 chr1:76189801 ACADM 0.59 7.32 0.37 1.9e-12 Blood metabolite levels;Acylcarnitine levels; CRC cis rs2976388 1.000 rs1045531 chr8:143763547 C/A cg22687807 chr8:143858763 LYNX1 -0.37 -6.47 -0.34 3.46e-10 Urinary tract infection frequency; CRC cis rs338389 0.516 rs7359201 chr15:68313749 T/C cg22576950 chr15:68522787 CLN6 -0.37 -6.17 -0.32 2.01e-9 Survival in rectal cancer; CRC cis rs6951245 1.000 rs28379681 chr7:1070539 C/T cg18402987 chr7:1209562 NA 0.64 6.77 0.35 6.03e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg14487482 chr3:135969043 PCCB 0.43 6.12 0.32 2.66e-9 Response to antipsychotic treatment; CRC cis rs6570726 0.967 rs7772286 chr6:145930423 A/T cg23711669 chr6:146136114 FBXO30 -0.65 -10.78 -0.51 2.18e-23 Lobe attachment (rater-scored or self-reported); CRC cis rs362272 0.545 rs3135146 chr4:3307638 C/G cg02993699 chr4:3415135 RGS12 0.34 5.67 0.3 3.1e-8 Serum sulfate level; CRC cis rs6952808 0.723 rs4721287 chr7:2028663 A/C cg04267008 chr7:1944627 MAD1L1 -0.78 -11.33 -0.53 2.45e-25 Bipolar disorder and schizophrenia; CRC cis rs9640161 0.742 rs2108853 chr7:150017589 A/C cg13722127 chr7:150037890 RARRES2 0.49 7.58 0.39 3.52e-13 Blood protein levels;Circulating chemerin levels; CRC cis rs6484504 0.600 rs972714 chr11:31358875 T/G cg14844989 chr11:31128820 NA 0.35 6.18 0.32 1.87e-9 Red blood cell count; CRC cis rs13272623 0.502 rs268599 chr8:71517401 G/T cg23757474 chr8:71581111 LACTB2;XKR9 -0.45 -6.47 -0.34 3.45e-10 IgG glycosylation; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg22852276 chr20:35724169 RBL1 0.41 6.06 0.32 3.72e-9 Intelligence (multi-trait analysis); CRC cis rs4731207 0.596 rs10231818 chr7:124574184 G/A cg23710748 chr7:124431027 NA -0.4 -6.25 -0.33 1.29e-9 Cutaneous malignant melanoma; CRC cis rs2361718 0.933 rs8066452 chr17:78104080 A/G cg27427491 chr17:78079615 GAA -0.37 -5.91 -0.31 8.59e-9 Yeast infection; CRC cis rs4663866 0.901 rs35390666 chr2:239193578 C/T cg16914508 chr2:239161102 PER2 0.73 7.62 0.39 2.78e-13 Irritable bowel syndrome; CRC cis rs667920 0.573 rs9682783 chr3:136539689 T/C cg15507776 chr3:136538369 TMEM22 0.43 6.6 0.34 1.62e-10 Coronary artery disease; CRC cis rs7772486 0.754 rs4896832 chr6:145964151 G/A cg05347473 chr6:146136440 FBXO30 0.38 5.71 0.3 2.52e-8 Lobe attachment (rater-scored or self-reported); CRC cis rs56235845 0.694 rs11749830 chr5:176766547 G/A cg17509989 chr5:176798049 RGS14 0.61 10.18 0.49 2.35e-21 Hemoglobin concentration;Hematocrit; CRC cis rs10504229 0.775 rs55764517 chr8:58158238 G/A cg02290350 chr8:58132656 NA -0.51 -6.39 -0.33 5.68e-10 Developmental language disorder (linguistic errors); CRC cis rs514406 0.929 rs485631 chr1:53330245 A/G cg24675658 chr1:53192096 ZYG11B -0.54 -7.86 -0.4 5.42e-14 Monocyte count; CRC cis rs6860806 0.507 rs273901 chr5:131694360 G/T cg12564285 chr5:131593104 PDLIM4 0.45 7.55 0.38 4.27e-13 Breast cancer; CRC cis rs533581 0.866 rs502258 chr16:88968547 G/A cg05579598 chr16:88989069 CBFA2T3 0.35 6.85 0.35 3.59e-11 Social autistic-like traits; CRC cis rs478304 0.903 rs495961 chr11:65540886 C/T cg08755490 chr11:65554678 OVOL1 0.4 5.81 0.31 1.48e-8 Acne (severe); CRC cis rs798554 0.757 rs2644312 chr7:2841164 G/A cg04166393 chr7:2884313 GNA12 0.49 6.57 0.34 1.92e-10 Height; CRC cis rs9311474 0.629 rs7639267 chr3:52568805 G/T cg08365687 chr3:52569147 NT5DC2;LOC440957 0.36 6.0 0.31 5.28e-9 Electroencephalogram traits; CRC cis rs7647973 0.769 rs4974081 chr3:49070499 A/G cg20833759 chr3:49053208 WDR6;DALRD3 -0.73 -11.84 -0.55 3.58e-27 Menarche (age at onset); CRC cis rs9322193 0.923 rs62441279 chr6:150042330 G/A cg07701084 chr6:150067640 NUP43 0.57 8.36 0.42 1.82e-15 Lung cancer; CRC trans rs6550704 0.687 rs9865314 chr3:22634337 A/G cg10620530 chr9:139922595 C9orf139;ABCA2 -0.4 -5.97 -0.31 6.25e-9 Daytime sleep phenotypes; CRC trans rs9291683 0.530 rs13115193 chr4:9982191 C/T cg26043149 chr18:55253948 FECH 0.54 8.28 0.42 3.11e-15 Bone mineral density; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg03756088 chr1:230203084 GALNT2 0.43 6.08 0.32 3.42e-9 Anxiety disorder; CRC cis rs478304 0.654 rs7934036 chr11:65451020 G/T cg05805236 chr11:65401703 PCNXL3 -0.38 -6.24 -0.33 1.34e-9 Acne (severe); CRC cis rs554111 0.963 rs710312 chr1:21042462 A/G cg08890418 chr1:21044141 KIF17 0.31 5.73 0.3 2.33e-8 Facial morphology (factor 17, height of vermillion upper lip); CRC trans rs561341 0.689 rs578635 chr17:30289897 A/C cg20587970 chr11:113659929 NA -0.66 -9.25 -0.45 2.82e-18 Hip circumference adjusted for BMI; CRC cis rs4713118 0.866 rs2179094 chr6:27741825 T/C cg12273811 chr6:28175739 NA 0.51 6.82 0.35 4.5e-11 Parkinson's disease; CRC cis rs6964587 0.967 rs9656003 chr7:91766322 A/C cg17063962 chr7:91808500 NA 0.84 14.96 0.64 5.65e-39 Breast cancer; CRC cis rs9902453 0.817 rs62068625 chr17:28176581 G/A cg26525008 chr17:28256777 EFCAB5;SSH2 0.59 8.88 0.44 4.49e-17 Coffee consumption (cups per day); CRC cis rs908922 0.676 rs1970283 chr1:152495619 G/C cg09873164 chr1:152488093 CRCT1 0.36 5.99 0.31 5.48e-9 Hair morphology; CRC cis rs629535 0.911 rs688612 chr8:70011887 C/T cg26132723 chr8:70041827 NA -0.36 -5.88 -0.31 9.89e-9 Dupuytren's disease; CRC cis rs4665809 1.000 rs4665304 chr2:26313406 C/T cg26119090 chr2:26468346 HADHA;HADHB -0.6 -7.89 -0.4 4.37e-14 Gut microbiome composition (summer); CRC cis rs11166927 0.967 rs12680346 chr8:140814379 C/T cg16909799 chr8:140841666 TRAPPC9 0.36 5.7 0.3 2.71e-8 Pediatric non-alcoholic fatty liver disease activity score; CRC cis rs9487051 1.000 rs6568570 chr6:109613241 T/G cg21918786 chr6:109611834 NA -0.38 -6.45 -0.34 3.94e-10 Reticulocyte fraction of red cells; CRC cis rs12142240 0.698 rs56284503 chr1:46847127 C/G cg14993813 chr1:46806288 NSUN4 -0.48 -6.03 -0.32 4.47e-9 Menopause (age at onset); CRC cis rs6089829 1.000 rs62207535 chr20:61669187 A/G cg03213289 chr20:61660250 NA 0.35 6.74 0.35 6.94e-11 Prostate cancer (SNP x SNP interaction); CRC cis rs9914988 0.778 rs9907192 chr17:27122426 C/G cg07195577 chr17:27052828 TLCD1 0.42 6.02 0.32 4.64e-9 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs4727027 0.870 rs62507485 chr7:148764182 C/T cg23583168 chr7:148888333 NA -0.86 -14.39 -0.62 9.73e-37 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC cis rs2067615 0.524 rs7309351 chr12:107077432 C/T cg13491945 chr12:107078410 RFX4 -0.35 -6.11 -0.32 2.88e-9 Heart rate; CRC cis rs6460942 1.000 rs2033871 chr7:12405098 C/A cg06484146 chr7:12443880 VWDE -0.75 -7.83 -0.4 6.98e-14 Coronary artery disease; CRC cis rs10504229 0.906 rs6990615 chr8:58182956 G/A cg22535103 chr8:58192502 C8orf71 -0.82 -12.27 -0.56 9.63e-29 Developmental language disorder (linguistic errors); CRC cis rs6141769 0.542 rs6057625 chr20:31304994 G/A cg13636640 chr20:31349939 DNMT3B -0.39 -5.87 -0.31 1.04e-8 Subjective well-being; CRC cis rs4862750 0.872 rs6830828 chr4:187897472 T/G cg03452623 chr4:187889614 NA -0.93 -22.01 -0.77 1.17e-66 Lobe attachment (rater-scored or self-reported); CRC cis rs8072100 0.701 rs8075566 chr17:45771037 G/A cg19784903 chr17:45786737 TBKBP1 -0.34 -5.61 -0.3 4.35e-8 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs12476592 0.571 rs2592386 chr2:63894064 A/G cg10828910 chr2:63850056 LOC388955 0.51 6.44 0.33 4.22e-10 Childhood ear infection; CRC cis rs9549260 0.755 rs58919811 chr13:41226485 A/C cg21288729 chr13:41239152 FOXO1 0.49 7.63 0.39 2.54e-13 Red blood cell count; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg02099313 chr1:231114956 TTC13;ARV1 0.45 6.43 0.33 4.52e-10 Response to antipsychotic treatment; CRC cis rs2153535 0.580 rs6597327 chr6:8482157 G/A cg07606381 chr6:8435919 SLC35B3 0.68 10.89 0.51 8.84e-24 Motion sickness; CRC cis rs9926296 0.609 rs4785714 chr16:89798404 G/T cg03605463 chr16:89740564 NA 0.41 6.07 0.32 3.43e-9 Vitiligo; CRC cis rs11792861 0.926 rs72607170 chr9:111836941 G/A cg05043794 chr9:111880884 C9orf5 -0.36 -6.56 -0.34 2.03e-10 Menarche (age at onset); CRC cis rs1218582 0.772 rs12095061 chr1:154912968 A/T cg03351412 chr1:154909251 PMVK 0.53 8.43 0.42 1.07e-15 Prostate cancer; CRC cis rs2976388 1.000 rs1045574 chr8:143763958 C/T cg20041105 chr8:143859282 LYNX1 -0.33 -5.89 -0.31 9.77e-9 Urinary tract infection frequency; CRC cis rs826838 1.000 rs9795768 chr12:39012479 T/C cg13010199 chr12:38710504 ALG10B 0.45 5.84 0.31 1.23e-8 Heart rate; CRC cis rs1018836 0.828 rs2105968 chr8:91591825 A/G cg16814680 chr8:91681699 NA -0.65 -10.07 -0.49 5.67e-21 Ejection fraction in Tripanosoma cruzi seropositivity; CRC cis rs11229555 0.645 rs11229436 chr11:58186009 G/A cg15696309 chr11:58395628 NA -0.81 -10.31 -0.49 8.83e-22 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; CRC trans rs4295623 0.531 rs2898295 chr8:11595969 C/T cg27411982 chr8:10470053 RP1L1 -0.39 -6.28 -0.33 1.07e-9 Morning vs. evening chronotype; CRC cis rs826838 1.000 rs826892 chr12:39100790 T/C cg13010199 chr12:38710504 ALG10B -0.4 -6.04 -0.32 4.27e-9 Heart rate; CRC cis rs9660180 0.868 rs12567685 chr1:1806647 T/C cg13866156 chr1:1669148 SLC35E2 -0.63 -9.78 -0.47 5.35e-20 Body mass index; CRC trans rs10838798 0.523 rs2019093 chr11:48196553 G/A cg21153622 chr11:89784906 NA -0.48 -7.7 -0.39 1.65e-13 Height; CRC trans rs875971 0.660 rs2191268 chr7:66110224 C/T cg16189954 chr22:29138267 HSCB;CHEK2 -0.38 -6.06 -0.32 3.65e-9 Aortic root size; CRC cis rs1691799 0.899 rs1168318 chr12:66745269 A/G cg16791601 chr12:66731901 HELB 0.69 11.86 0.55 2.9e-27 White blood cell count (basophil); CRC cis rs9393692 0.627 rs1059486 chr6:26200083 A/G cg13736514 chr6:26305472 NA -0.53 -9.31 -0.46 1.91e-18 Educational attainment; CRC trans rs12310956 0.532 rs11052948 chr12:33981973 T/C cg26384229 chr12:38710491 ALG10B 0.51 6.43 0.33 4.44e-10 Morning vs. evening chronotype; CRC cis rs5753618 0.583 rs5753631 chr22:31863022 A/C cg22777020 chr22:31556080 RNF185 0.46 5.61 0.3 4.21e-8 Colorectal cancer; CRC cis rs1524976 0.941 rs1404550 chr3:65487427 G/C cg16238336 chr3:65465873 MAGI1 0.5 6.43 0.33 4.59e-10 PR interval; CRC cis rs9911578 0.967 rs2643124 chr17:56741672 T/C cg05425664 chr17:57184151 TRIM37 -0.5 -7.93 -0.4 3.52e-14 Intelligence (multi-trait analysis); CRC cis rs12913538 0.747 rs7167910 chr15:62888516 C/T cg09983546 chr15:62884068 NA -0.5 -7.73 -0.39 1.36e-13 Sleep depth; CRC cis rs2242116 0.796 rs7645278 chr3:46974100 A/C cg02527881 chr3:46936655 PTH1R -0.5 -8.79 -0.44 8.23e-17 Birth weight; CRC cis rs6088813 1.000 rs6088825 chr20:33995972 C/T cg14752227 chr20:34000481 UQCC -0.37 -5.75 -0.3 2.01e-8 Height; CRC cis rs4713118 0.868 rs2893928 chr6:27738430 C/A cg20933634 chr6:27740509 NA 0.58 6.43 0.33 4.56e-10 Parkinson's disease; CRC cis rs3789045 1.000 rs3747631 chr1:204587569 G/C cg17419461 chr1:204415978 PIK3C2B -0.49 -6.94 -0.36 2.05e-11 Educational attainment (college completion); CRC cis rs4889855 0.556 rs9911795 chr17:78626115 T/C cg16591659 chr17:78472290 NA -0.41 -6.09 -0.32 3.1e-9 Fractional excretion of uric acid; CRC cis rs12745968 0.623 rs4294424 chr1:93139374 T/C cg17283838 chr1:93427260 FAM69A -0.47 -6.37 -0.33 6.34e-10 Bipolar disorder and schizophrenia; CRC cis rs4713118 0.869 rs6930992 chr6:27712120 A/C cg12273811 chr6:28175739 NA 0.53 7.64 0.39 2.4e-13 Parkinson's disease; CRC cis rs6933660 0.760 rs6904364 chr6:151754273 T/C cg10883421 chr6:151773342 RMND1;C6orf211 0.57 9.01 0.44 1.71e-17 Menarche (age at onset); CRC cis rs2882667 0.898 rs6882330 chr5:138382182 A/G cg09476006 chr5:138032270 NA 0.44 7.4 0.38 1.12e-12 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs2153535 0.580 rs1414342 chr6:8462552 A/G cg07606381 chr6:8435919 SLC35B3 0.67 10.66 0.51 5.39e-23 Motion sickness; CRC cis rs8062405 1.000 rs1987472 chr16:28825777 C/T cg08761264 chr16:28874980 SH2B1 -0.42 -5.62 -0.3 4.08e-8 Cognitive ability (multi-trait analysis);Cognitive ability; CRC cis rs2455601 0.671 rs10840135 chr11:8879794 T/C cg09997546 chr11:8931473 C11orf17;ST5 -0.4 -5.92 -0.31 8.21e-9 Schizophrenia; CRC cis rs9443645 0.901 rs12193319 chr6:79583437 C/A cg11833968 chr6:79620685 NA -0.37 -6.47 -0.34 3.53e-10 Intelligence (multi-trait analysis); CRC cis rs11792861 0.781 rs2297581 chr9:111755008 C/T cg05043794 chr9:111880884 C9orf5 -0.33 -5.81 -0.31 1.45e-8 Menarche (age at onset); CRC cis rs8005677 1.000 rs8006409 chr14:23396511 A/G cg01529538 chr14:23388837 RBM23 0.39 6.12 0.32 2.68e-9 Cognitive ability (multi-trait analysis); CRC cis rs3924048 0.574 rs12096486 chr1:12616911 T/C cg23650765 chr1:12612165 NA 0.35 6.62 0.34 1.48e-10 Optic cup area; CRC cis rs853679 0.517 rs9357065 chr6:28129580 T/C cg21251018 chr6:28226885 NKAPL 0.49 6.27 0.33 1.14e-9 Depression; CRC cis rs875971 0.862 rs28491091 chr7:65669064 G/T cg18876405 chr7:65276391 NA -0.54 -8.74 -0.43 1.21e-16 Aortic root size; CRC cis rs9381040 0.655 rs2294695 chr6:41036770 A/G cg03644281 chr6:41068752 NFYA;LOC221442 -0.43 -6.08 -0.32 3.4e-9 Alzheimer's disease (late onset); CRC cis rs13191362 1.000 rs55847707 chr6:163003414 G/A cg06582575 chr6:163149167 PACRG;PARK2 0.77 10.7 0.51 3.98e-23 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC trans rs2018683 0.677 rs55718000 chr7:28975625 T/C cg19402173 chr7:128379420 CALU -0.43 -6.3 -0.33 9.61e-10 Response to irinotecan and platinum-based chemotherapy in non-small-cell lung cancer; CRC cis rs4862750 1.000 rs4862751 chr4:187904050 G/A cg10295955 chr4:187884368 NA -1.05 -25.27 -0.81 4.48e-79 Lobe attachment (rater-scored or self-reported); CRC cis rs6540559 1.000 rs6659367 chr1:209982408 G/T cg21951975 chr1:209979733 IRF6 0.43 6.66 0.34 1.14e-10 Cleft lip with or without cleft palate; CRC cis rs2985684 0.948 rs11623263 chr14:50083295 A/G cg04989706 chr14:50066350 PPIL5 -0.6 -8.2 -0.41 5.54e-15 Carotid intima media thickness; CRC cis rs2637266 0.561 rs11492375 chr10:78513974 T/C cg18941641 chr10:78392320 NA -0.36 -6.18 -0.32 1.91e-9 Pulmonary function; CRC trans rs7267979 0.844 rs869358 chr20:25374674 A/G cg17903999 chr18:56338584 MALT1 0.42 6.72 0.35 8.23e-11 Liver enzyme levels (alkaline phosphatase); CRC cis rs4970988 0.527 rs12067556 chr1:150614535 G/A cg17724175 chr1:150552817 MCL1 0.67 10.72 0.51 3.53e-23 Urate levels; CRC cis rs7613875 0.580 rs6808044 chr3:50136165 A/G cg24110177 chr3:50126178 RBM5 0.56 8.37 0.42 1.64e-15 Body mass index; CRC cis rs6951245 1.000 rs78523927 chr7:1089458 T/C cg21664854 chr7:1097933 C7orf50;GPR146 0.79 8.71 0.43 1.52e-16 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs344364 0.511 rs62040571 chr16:1948514 C/G cg14074117 chr16:1909714 C16orf73 0.41 5.66 0.3 3.28e-8 Glomerular filtration rate in chronic kidney disease; CRC cis rs1552244 0.816 rs17050701 chr3:10041554 A/G cg00166722 chr3:10149974 C3orf24 0.61 8.0 0.4 2.17e-14 Alzheimer's disease; CRC cis rs4481887 0.927 rs7521689 chr1:248435831 G/T cg00666640 chr1:248458726 OR2T12 0.58 10.22 0.49 1.79e-21 Common traits (Other); CRC cis rs11148252 0.514 rs3783242 chr13:52717950 C/T cg12458913 chr13:53173898 NA 0.39 5.68 0.3 2.97e-8 Lewy body disease; CRC cis rs7618915 0.547 rs2590846 chr3:52692359 C/G cg15147215 chr3:52552868 STAB1 -0.62 -10.28 -0.49 1.13e-21 Bipolar disorder; CRC cis rs28386778 0.966 rs2008053 chr17:61954918 G/C cg22520471 chr17:61851767 DDX42;CCDC47 0.7 10.96 0.52 5.02e-24 Prudent dietary pattern; CRC trans rs66573146 0.831 rs56300156 chr4:6990813 G/C cg07817883 chr1:32538562 TMEM39B 1.24 11.59 0.54 2.8e-26 Granulocyte percentage of myeloid white cells; CRC cis rs28386778 0.897 rs2727327 chr17:61923422 G/A cg25654072 chr17:61904446 PSMC5;FTSJ3 0.72 11.19 0.52 7.76e-25 Prudent dietary pattern; CRC cis rs4731207 0.505 rs7791488 chr7:124578268 A/G cg23710748 chr7:124431027 NA -0.42 -6.57 -0.34 1.98e-10 Cutaneous malignant melanoma; CRC cis rs12472274 0.618 rs12477307 chr2:239110514 G/T cg17459225 chr2:239074497 NA 0.63 10.45 0.5 3.01e-22 Phospholipid levels (plasma); CRC cis rs10504229 0.512 rs117968470 chr8:58014651 C/G cg21724239 chr8:58056113 NA 0.77 9.81 0.48 4.41e-20 Developmental language disorder (linguistic errors); CRC cis rs17767392 0.958 rs7156313 chr14:72052310 G/C cg13720639 chr14:72061746 SIPA1L1 0.57 7.1 0.36 7.61e-12 Mitral valve prolapse; CRC cis rs10504229 0.861 rs67042991 chr8:58191749 G/C cg02725872 chr8:58115012 NA -0.38 -6.43 -0.33 4.44e-10 Developmental language disorder (linguistic errors); CRC cis rs9911578 1.000 rs4372750 chr17:57013803 A/C cg12560992 chr17:57184187 TRIM37 -0.92 -17.04 -0.68 4.2e-47 Intelligence (multi-trait analysis); CRC cis rs6502050 0.835 rs6502079 chr17:80124454 T/A cg11859384 chr17:80120422 CCDC57 -0.36 -5.75 -0.3 2.06e-8 Life satisfaction; CRC cis rs2408955 0.568 rs12099462 chr12:48503104 T/C cg00601486 chr12:48723148 H1FNT -0.35 -6.75 -0.35 6.49e-11 Glycated hemoglobin levels; CRC cis rs561341 0.769 rs8074383 chr17:30178793 C/T cg00745463 chr17:30367425 LRRC37B 0.72 7.51 0.38 5.5e-13 Hip circumference adjusted for BMI; CRC cis rs826838 0.967 rs11168985 chr12:39045983 A/C cg26384229 chr12:38710491 ALG10B -0.68 -9.24 -0.45 3.2e-18 Heart rate; CRC trans rs10842750 1.000 rs10842750 chr12:26690565 G/T cg08697092 chr19:56879933 ZNF542 0.36 6.29 0.33 9.99e-10 Kashin-Beck disease; CRC cis rs9811920 0.609 rs6809988 chr3:99656615 A/G cg07805332 chr3:99536008 MIR548G;C3orf26 0.51 7.67 0.39 1.91e-13 Axial length; CRC cis rs727505 0.954 rs989177 chr7:124412886 A/G cg23710748 chr7:124431027 NA -0.84 -13.84 -0.61 1.18e-34 Lewy body disease; CRC cis rs78456975 0.943 rs13421238 chr2:1576879 G/A cg26248373 chr2:1572462 NA -0.65 -7.71 -0.39 1.49e-13 Placebo response in major depressive disorder (% change in symptom score); CRC cis rs7264396 1.000 rs7264396 chr20:34154741 A/G cg04508476 chr20:34239394 CPNE1;RBM12 0.45 7.41 0.38 1.07e-12 Total cholesterol levels; CRC cis rs889312 0.500 rs1867731 chr5:56132115 C/G cg03609598 chr5:56110824 MAP3K1 -0.42 -5.94 -0.31 7.28e-9 Breast cancer;Breast cancer (early onset); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg21775445 chr20:1373916 FKBP1A 0.42 5.96 0.31 6.48e-9 Response to antipsychotic treatment; CRC cis rs10751667 0.666 rs7396677 chr11:958878 C/T cg01483505 chr11:975446 AP2A2 0.46 7.67 0.39 2.02e-13 Alzheimer's disease (late onset); CRC cis rs1799949 0.930 rs4584865 chr17:41424919 C/G cg05368731 chr17:41323189 NBR1 0.67 10.1 0.49 4.69e-21 Menopause (age at onset); CRC cis rs2976388 0.647 rs2082801 chr8:143786461 A/G cg04969067 chr8:143858791 LYNX1 0.45 7.61 0.39 2.99e-13 Urinary tract infection frequency; CRC cis rs6582630 0.502 rs11614397 chr12:38328163 C/T cg26384229 chr12:38710491 ALG10B 0.67 9.37 0.46 1.19e-18 Drug-induced liver injury (flucloxacillin); CRC trans rs11764590 0.694 rs60626033 chr7:2099719 A/G cg11693508 chr17:37793320 STARD3 0.48 6.44 0.33 4.14e-10 Neuroticism; CRC cis rs9914988 0.832 rs9903248 chr17:27127439 G/T cg16670446 chr17:27188758 MIR451;MIR144 0.55 8.52 0.43 5.75e-16 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs514406 0.861 rs72637996 chr1:53249618 A/T cg08859206 chr1:53392774 SCP2 0.43 6.92 0.36 2.43e-11 Monocyte count; CRC cis rs12476592 0.602 rs1446563 chr2:63898124 T/G cg10828910 chr2:63850056 LOC388955 0.51 6.44 0.33 4.22e-10 Childhood ear infection; CRC cis rs2421770 0.504 rs7943314 chr11:35363823 A/G cg13971030 chr11:35366721 SLC1A2 -0.39 -6.74 -0.35 7.04e-11 Staphylococcus aureus nasal carriage (persistent); CRC cis rs875971 0.660 rs801211 chr7:66015689 T/G cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.43 -6.46 -0.34 3.8e-10 Aortic root size; CRC cis rs17253792 0.545 rs12883972 chr14:56018020 A/G cg01858014 chr14:56050164 KTN1 -0.86 -6.64 -0.34 1.27e-10 Putamen volume; CRC cis rs2976388 0.609 rs2585153 chr8:143785345 G/A cg05569086 chr8:143859399 LYNX1 0.4 6.91 0.36 2.51e-11 Urinary tract infection frequency; CRC cis rs1799949 0.930 rs4584865 chr17:41424919 C/G cg23758822 chr17:41437982 NA 0.8 13.54 0.6 1.66e-33 Menopause (age at onset); CRC trans rs561341 1.000 rs498391 chr17:30328704 G/A cg27661571 chr11:113659931 NA -0.94 -10.87 -0.51 9.91e-24 Hip circumference adjusted for BMI; CRC trans rs2055729 0.614 rs10108550 chr8:9741633 G/A cg06636001 chr8:8085503 FLJ10661 -0.53 -6.75 -0.35 6.83e-11 Multiple myeloma (hyperdiploidy); CRC cis rs6942756 1.000 rs6971917 chr7:128976919 G/A cg02491457 chr7:128862824 NA -0.77 -10.26 -0.49 1.32e-21 White matter hyperintensity burden; CRC cis rs4664293 0.867 rs11681245 chr2:160629393 A/G cg08347373 chr2:160653686 CD302 -0.47 -7.43 -0.38 9.32e-13 Monocyte percentage of white cells; CRC cis rs477692 0.604 rs1008982 chr10:131445731 T/C cg05714579 chr10:131428358 MGMT -0.77 -11.89 -0.55 2.31e-27 Response to temozolomide; CRC cis rs672059 1.000 rs575474 chr1:183158599 T/C ch.1.3577855R chr1:183094577 LAMC1 0.5 7.28 0.37 2.41e-12 Hypertriglyceridemia; CRC cis rs7605827 0.930 rs13004154 chr2:15664325 A/G cg19274914 chr2:15703543 NA 0.37 5.65 0.3 3.43e-8 Educational attainment (years of education); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg17627654 chr11:70508410 SHANK2 0.21 6.28 0.33 1.09e-9 Liver disease severity in Alagille syndrome; CRC cis rs1218582 0.682 rs12046459 chr1:154912017 A/C cg16680214 chr1:154839983 KCNN3 -0.46 -8.78 -0.44 8.92e-17 Prostate cancer; CRC cis rs7618915 0.547 rs62253733 chr3:52653414 A/G cg18099408 chr3:52552593 STAB1 -0.44 -7.12 -0.37 6.88e-12 Bipolar disorder; CRC trans rs62103177 1.000 rs62103177 chr18:77624479 G/A cg05926928 chr17:57297772 GDPD1 1.06 9.97 0.48 1.21e-20 Opioid sensitivity; CRC cis rs8177253 1.000 rs8177248 chr3:133479626 C/T cg01448562 chr3:133502909 NA -0.53 -8.75 -0.43 1.17e-16 Iron status biomarkers; CRC trans rs11148252 0.553 rs2147692 chr13:53287023 C/G cg18335740 chr13:41363409 SLC25A15 0.77 14.42 0.62 6.98e-37 Lewy body disease; CRC cis rs9549367 0.789 rs2025247 chr13:113882564 C/G cg00898013 chr13:113819073 PROZ -0.46 -6.75 -0.35 6.67e-11 Platelet distribution width; CRC trans rs6011368 0.585 rs13043326 chr20:62914092 C/A cg13869341 chr1:15865 WASH5P 0.42 6.1 0.32 2.99e-9 Clozapine-induced cytotoxicity; CRC cis rs73198271 0.531 rs56100346 chr8:8652844 C/T cg01851573 chr8:8652454 MFHAS1 0.55 6.84 0.35 3.76e-11 Bone ultrasound measurement (broadband ultrasound attenuation); CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg00224911 chr4:74486142 RASSF6 0.41 6.25 0.33 1.28e-9 Anxiety disorder; CRC cis rs9733 0.596 rs7412396 chr1:150666797 C/T cg17724175 chr1:150552817 MCL1 0.56 9.06 0.45 1.23e-17 Tonsillectomy; CRC cis rs7660520 0.524 rs4862100 chr4:183732709 G/T cg12483801 chr4:183727862 NA 0.66 7.92 0.4 3.78e-14 Pediatric autoimmune diseases; CRC trans rs1005277 0.579 rs1740732 chr10:38491385 C/T cg23533926 chr12:111358616 MYL2 -0.56 -8.7 -0.43 1.64e-16 Extrinsic epigenetic age acceleration; CRC cis rs9903692 0.909 rs8078125 chr17:46145709 T/G cg21215337 chr17:46176117 CBX1 0.42 7.78 0.39 9.36e-14 Pulse pressure; CRC cis rs1707322 0.752 rs6662164 chr1:46146230 T/A cg03146154 chr1:46216737 IPP 0.63 9.15 0.45 6.05e-18 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg13433994 chr3:23958502 NKIRAS1;RPL15 0.37 5.99 0.31 5.59e-9 Liver disease severity in Alagille syndrome; CRC cis rs736801 0.607 rs11746555 chr5:131727033 G/A cg11843238 chr5:131593191 PDLIM4 0.33 5.77 0.3 1.85e-8 Breast cancer;Mosquito bite size; CRC cis rs4423214 0.515 rs4944042 chr11:71118788 C/A cg05163923 chr11:71159392 DHCR7 0.41 5.78 0.3 1.73e-8 Vitamin D levels; CRC cis rs863345 0.604 rs12120526 chr1:158498404 T/C cg12129480 chr1:158549410 OR10X1 -0.3 -6.27 -0.33 1.12e-9 Pneumococcal bacteremia; CRC cis rs7937682 0.889 rs484013 chr11:111495779 G/A cg09085632 chr11:111637200 PPP2R1B -0.98 -19.37 -0.73 2.48e-56 Primary sclerosing cholangitis; CRC cis rs763121 0.853 rs5757203 chr22:39044152 G/C cg06544989 chr22:39130855 UNC84B 0.44 6.84 0.35 3.76e-11 Menopause (age at onset); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg03932406 chr2:65657881 SPRED2 0.4 6.16 0.32 2.07e-9 Intelligence (multi-trait analysis); CRC cis rs3093024 0.904 rs3093019 chr6:167539655 C/G cg07741184 chr6:167504864 NA -0.32 -5.68 -0.3 2.95e-8 Rheumatoid arthritis; CRC trans rs11098499 0.661 rs10015965 chr4:120268237 A/G cg25214090 chr10:38739885 LOC399744 0.54 8.48 0.42 7.87e-16 Corneal astigmatism; CRC cis rs1008375 1.000 rs1121091 chr4:17676386 A/C cg16339924 chr4:17578868 LAP3 0.5 6.55 0.34 2.27e-10 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs4689592 0.619 rs3796908 chr4:7061378 G/A cg19539972 chr4:7069911 GRPEL1 0.83 10.53 0.5 1.57e-22 Monocyte percentage of white cells; CRC cis rs1534166 0.647 rs9853615 chr3:133519981 C/T cg01448562 chr3:133502909 NA -0.47 -7.0 -0.36 1.45e-11 Alcohol consumption (transferrin glycosylation); CRC cis rs654950 0.806 rs7550496 chr1:42043834 G/A cg06885757 chr1:42089581 HIVEP3 0.49 8.16 0.41 7.38e-15 Airway imaging phenotypes; CRC cis rs769267 0.930 rs4808203 chr19:19568659 A/G cg03709012 chr19:19516395 GATAD2A 0.74 11.11 0.52 1.46e-24 Tonsillectomy; CRC cis rs11212617 0.935 rs11212543 chr11:108054922 G/A cg14761454 chr11:108092087 ATM;NPAT 0.42 6.31 0.33 8.94e-10 Response to metformin in type 2 diabetes (glycemic); CRC cis rs501916 0.634 rs603569 chr15:48058929 G/A cg16110827 chr15:48056943 SEMA6D -0.43 -6.59 -0.34 1.73e-10 Inflammatory bowel disease;Ulcerative colitis; CRC cis rs4665809 0.838 rs6546780 chr2:26352857 T/C cg25036284 chr2:26402008 FAM59B -0.46 -5.98 -0.31 5.71e-9 Gut microbiome composition (summer); CRC cis rs7333181 0.858 rs34554065 chr13:112241190 T/C cg27543320 chr13:112200689 NA 0.49 6.1 0.32 2.93e-9 Menopause (age at onset); CRC cis rs17376456 0.757 rs1031424 chr5:93139706 G/C cg21475434 chr5:93447410 FAM172A 0.71 7.26 0.37 2.82e-12 Diabetic retinopathy; CRC trans rs561341 1.000 rs1681718 chr17:30296445 G/A cg20587970 chr11:113659929 NA -1.43 -20.42 -0.75 2e-60 Hip circumference adjusted for BMI; CRC cis rs782590 0.935 rs782649 chr2:55860308 T/C cg18811423 chr2:55921094 PNPT1 0.81 14.72 0.63 4.88e-38 Metabolic syndrome; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg27409012 chr1:162531173 UAP1 0.44 6.31 0.33 8.9e-10 Intelligence (multi-trait analysis); CRC cis rs11122272 0.735 rs2486741 chr1:231516450 G/C cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.54 -8.09 -0.41 1.18e-14 Hemoglobin concentration; CRC cis rs12230513 0.732 rs7957446 chr12:55839631 G/C cg19537932 chr12:55886519 OR6C68 -0.73 -9.52 -0.46 3.95e-19 Contrast sensitivity; CRC cis rs17155006 0.746 rs446800 chr7:107747928 A/C cg05962710 chr7:107745446 LAMB4 -0.41 -7.44 -0.38 8.61e-13 Pneumococcal bacteremia; CRC cis rs727505 0.721 rs11534064 chr7:124767997 G/T cg23710748 chr7:124431027 NA 0.64 11.28 0.53 3.48e-25 Lewy body disease; CRC cis rs1862618 0.853 rs2548664 chr5:56133555 G/A cg22800045 chr5:56110881 MAP3K1 0.58 6.44 0.33 4.15e-10 Initial pursuit acceleration; CRC cis rs6860806 0.507 rs635619 chr5:131720265 G/A cg20512303 chr5:131592959 PDLIM4 -0.4 -6.91 -0.36 2.5e-11 Breast cancer; CRC trans rs7615952 0.736 rs13063122 chr3:125643860 G/A cg07211511 chr3:129823064 LOC729375 -1.12 -18.23 -0.71 7.93e-52 Blood pressure (smoking interaction); CRC cis rs897984 0.609 rs35468353 chr16:31056433 A/G cg00531865 chr16:30841666 NA -0.44 -6.28 -0.33 1.05e-9 Dementia with Lewy bodies; CRC trans rs9858542 0.953 rs6997 chr3:49453834 C/T cg21659725 chr3:3221576 CRBN -0.65 -8.9 -0.44 3.88e-17 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC trans rs916888 0.821 rs199514 chr17:44856881 G/A cg07870213 chr5:140052090 DND1 -0.83 -9.54 -0.47 3.28e-19 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs12024301 0.557 rs75281768 chr1:183645768 G/A cg11505048 chr1:183622726 RGL1;APOBEC4 0.73 6.43 0.33 4.43e-10 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs1799949 1.000 rs36036395 chr17:41181297 T/C cg01879757 chr17:41196368 BRCA1 -0.41 -6.07 -0.32 3.62e-9 Menopause (age at onset); CRC cis rs7249142 0.549 rs2239369 chr19:19292405 A/T cg12558012 chr19:19281197 LOC729991-MEF2B;MEF2B -0.56 -8.92 -0.44 3.37e-17 IgG glycosylation; CRC cis rs875971 0.862 rs9791713 chr7:66105198 C/A cg18252515 chr7:66147081 NA 0.42 5.95 0.31 7.03e-9 Aortic root size; CRC cis rs1005277 0.579 rs932538 chr10:38381314 T/C cg03665457 chr10:38645376 HSD17B7P2 -0.42 -6.05 -0.32 3.9e-9 Extrinsic epigenetic age acceleration; CRC trans rs564309 1.000 rs491670 chr1:228599952 G/C cg24066601 chr6:26271455 HIST1H3G 0.57 6.17 0.32 1.99e-9 Hip circumference (psychosocial stress interaction); CRC cis rs28386778 0.799 rs2665836 chr17:61898135 C/A cg11494091 chr17:61959527 GH2 0.63 10.63 0.51 6.97e-23 Prudent dietary pattern; CRC cis rs11583043 1.000 rs7521424 chr1:101475901 T/C cg16556008 chr1:101360663 SLC30A7;EXTL2 0.45 5.68 0.3 3.01e-8 Ulcerative colitis;Inflammatory bowel disease; CRC cis rs2857891 0.697 rs1004754 chr11:6946248 T/C cg17958423 chr11:6947583 ZNF215 0.58 6.04 0.32 4.27e-9 Response to cytadine analogues (cytosine arabinoside); CRC cis rs9894429 1.000 rs11651264 chr17:79576394 A/G cg18240062 chr17:79603768 NPLOC4 -0.56 -9.34 -0.46 1.54e-18 Eye color traits; CRC cis rs2153535 0.601 rs9379224 chr6:8538413 A/G cg07606381 chr6:8435919 SLC35B3 0.67 10.94 0.52 5.73e-24 Motion sickness; CRC cis rs887829 0.570 rs10171367 chr2:234597667 C/G cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.46 -7.13 -0.37 6.28e-12 Metabolic traits;Bilirubin levels;Cholelithiasis-related traits in sickle cell anemia;Metabolite levels;Total bilirubin levels in HIV-1 infection;Serum metabolite levels;Blood metabolite levels; CRC cis rs300703 0.872 rs12233077 chr2:120949 T/A cg21211680 chr2:198530 NA -0.95 -8.8 -0.44 8.1e-17 Blood protein levels; CRC cis rs8141797 0.901 rs17004848 chr22:24538918 C/T cg20894457 chr22:24584366 SUSD2 0.65 6.98 0.36 1.62e-11 Amyotrophic lateral sclerosis;Coronary artery disease; CRC cis rs1107366 1.000 rs1107366 chr3:125904165 A/G cg21601837 chr3:125900065 ALDH1L1 -0.35 -5.66 -0.3 3.23e-8 Metabolite levels; CRC cis rs270601 0.739 rs1979981 chr5:131601720 G/A cg18301423 chr5:131593218 PDLIM4 0.44 8.18 0.41 6.25e-15 Acylcarnitine levels; CRC cis rs926392 0.896 rs4812357 chr20:37683071 C/T cg16355469 chr20:37678765 NA -0.35 -5.67 -0.3 3.05e-8 Dialysis-related mortality; CRC cis rs4332037 0.707 rs62435130 chr7:1890002 C/T cg21155852 chr7:2048760 MAD1L1 -0.42 -6.07 -0.32 3.56e-9 Bipolar disorder; CRC cis rs7208859 0.673 rs73263776 chr17:29211331 G/C cg14008862 chr17:28927542 LRRC37B2 0.54 5.68 0.3 2.91e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs1348850 0.567 rs3770009 chr2:178536544 C/T cg02961200 chr2:178257176 LOC100130691;AGPS 0.53 7.14 0.37 5.93e-12 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs1881797 1.000 rs12071797 chr1:247686871 A/G cg18198730 chr1:247681584 NA 0.54 8.43 0.42 1.08e-15 Acute lymphoblastic leukemia (childhood); CRC cis rs17209837 0.607 rs17149644 chr7:87086218 T/C cg00919237 chr7:87102261 ABCB4 -0.54 -7.09 -0.36 8.37e-12 Gallbladder cancer; CRC trans rs11098499 0.908 rs2017057 chr4:120257711 A/G cg25214090 chr10:38739885 LOC399744 0.61 9.56 0.47 2.91e-19 Corneal astigmatism; CRC cis rs7605827 0.893 rs7590540 chr2:15719652 A/T cg19274914 chr2:15703543 NA 0.39 5.89 0.31 9.38e-9 Educational attainment (years of education); CRC cis rs6860806 0.507 rs274572 chr5:131710917 T/G cg24060327 chr5:131705240 SLC22A5 0.53 7.99 0.4 2.28e-14 Breast cancer; CRC cis rs561341 0.883 rs7219239 chr17:30212016 A/G cg00745463 chr17:30367425 LRRC37B 0.72 8.35 0.42 1.86e-15 Hip circumference adjusted for BMI; CRC cis rs826838 0.809 rs11169666 chr12:39211300 T/C cg26384229 chr12:38710491 ALG10B 0.69 9.33 0.46 1.61e-18 Heart rate; CRC cis rs2797160 1.000 rs2747724 chr6:126004935 G/A cg05901451 chr6:126070800 HEY2 -0.4 -6.18 -0.32 1.93e-9 Endometrial cancer; CRC cis rs1572438 0.899 rs3799325 chr6:859115 C/T cg13447295 chr6:887704 NA 0.42 6.1 0.32 2.95e-9 Aging; CRC cis rs853679 0.550 rs1237875 chr6:28173010 A/G cg03623178 chr6:28175578 NA -1.0 -15.2 -0.64 6.65e-40 Depression; CRC trans rs66759488 0.739 rs10851451 chr15:47608991 A/G cg01239735 chr12:214224 IQSEC3 -0.25 -6.28 -0.33 1.1e-9 Lung cancer; CRC cis rs629535 0.814 rs549643 chr8:70062884 C/T cg26132723 chr8:70041827 NA 0.34 5.69 0.3 2.82e-8 Dupuytren's disease; CRC cis rs9322193 0.923 rs9371207 chr6:150179223 A/G cg05861140 chr6:150128134 PCMT1 -0.43 -6.66 -0.34 1.13e-10 Lung cancer; CRC cis rs2274273 0.662 rs4040064 chr14:55678088 G/T cg10130446 chr14:55658398 DLGAP5 -0.43 -5.81 -0.31 1.46e-8 Protein biomarker; CRC cis rs4728302 0.869 rs6943986 chr7:133616965 G/A cg10665199 chr7:133106180 EXOC4 0.41 6.18 0.32 1.86e-9 Intelligence;Intelligence (multi-trait analysis); CRC cis rs34172651 0.517 rs189919 chr16:24737741 G/A cg00339695 chr16:24857497 SLC5A11 -0.4 -7.67 -0.39 2e-13 Intelligence (multi-trait analysis); CRC cis rs889312 0.500 rs866223 chr5:56125353 A/G cg12311346 chr5:56204834 C5orf35 -0.48 -7.18 -0.37 4.56e-12 Breast cancer;Breast cancer (early onset); CRC cis rs3785574 0.962 rs9944483 chr17:61783553 G/T cg11494091 chr17:61959527 GH2 -0.41 -6.5 -0.34 3.01e-10 Height; CRC cis rs4713118 0.539 rs510987 chr6:27847517 G/A cg15845792 chr6:28175446 NA 0.75 10.52 0.5 1.61e-22 Parkinson's disease; CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg12112058 chr1:224622605 WDR26 -0.49 -6.2 -0.32 1.65e-9 Diisocyanate-induced asthma; CRC trans rs10506458 0.915 rs2013042 chr12:63394211 A/G cg22491629 chr6:157744540 C6orf35 -0.78 -9.35 -0.46 1.41e-18 Hemostatic factors and hematological phenotypes; CRC cis rs12476592 0.602 rs4671516 chr2:63790555 G/T cg10828910 chr2:63850056 LOC388955 0.49 6.11 0.32 2.79e-9 Childhood ear infection; CRC cis rs11190604 1.000 rs7070776 chr10:102264672 A/G cg16342193 chr10:102329863 NA -0.33 -5.62 -0.3 3.98e-8 Palmitoleic acid (16:1n-7) levels; CRC cis rs7249142 0.562 rs10417796 chr19:19287072 A/G cg12558012 chr19:19281197 LOC729991-MEF2B;MEF2B 0.55 8.66 0.43 2.13e-16 IgG glycosylation; CRC cis rs802075 0.967 rs360563 chr6:49658270 C/T cg20364632 chr6:49636226 NA -0.37 -6.07 -0.32 3.46e-9 Bone mineral density (hip) and age at menarche; CRC cis rs9372498 0.536 rs2356501 chr6:118942371 C/A cg24463073 chr6:118973353 C6orf204 0.48 6.22 0.32 1.49e-9 Diastolic blood pressure; CRC cis rs6088590 1.000 rs6119512 chr20:33306904 T/C cg08999081 chr20:33150536 PIGU 0.51 8.58 0.43 3.74e-16 Coronary artery disease; CRC cis rs7666738 0.830 rs28444709 chr4:99028496 A/T cg05340658 chr4:99064831 C4orf37 0.61 9.42 0.46 8.23e-19 Colonoscopy-negative controls vs population controls; CRC cis rs6840360 0.593 rs1877186 chr4:152692418 C/G cg09659197 chr4:152720779 NA 0.38 7.96 0.4 2.84e-14 Intelligence (multi-trait analysis); CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg16388829 chr2:97202323 ARID5A -0.6 -7.33 -0.37 1.77e-12 Diisocyanate-induced asthma; CRC cis rs7429990 0.965 rs7426976 chr3:48022573 A/C cg11946769 chr3:48343235 NME6 -0.43 -5.71 -0.3 2.58e-8 Educational attainment (years of education); CRC cis rs28374715 0.662 rs72737786 chr15:41500361 G/T cg18705301 chr15:41695430 NDUFAF1 -0.93 -13.73 -0.6 3.19e-34 Ulcerative colitis; CRC cis rs12682352 0.579 rs7006589 chr8:8668486 A/G cg06636001 chr8:8085503 FLJ10661 0.55 8.62 0.43 2.87e-16 Neuroticism; CRC cis rs6547741 0.717 rs2178197 chr2:27860551 C/T cg22903471 chr2:27725779 GCKR 0.33 5.66 0.3 3.37e-8 Oral cavity cancer; CRC cis rs1577917 0.958 rs13213899 chr6:86473140 C/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.61 -7.67 -0.39 1.95e-13 Response to antipsychotic treatment; CRC cis rs7680126 0.595 rs17251963 chr4:10142561 A/G cg11266682 chr4:10021025 SLC2A9 -0.43 -6.11 -0.32 2.86e-9 Urate levels in lean individuals;Urate levels in overweight individuals;Urate levels in obese individuals; CRC cis rs1728785 1.000 rs821167 chr16:68577222 T/G cg02972257 chr16:68554789 NA -0.62 -7.26 -0.37 2.77e-12 Ulcerative colitis; CRC cis rs11122272 0.735 rs2790890 chr1:231514567 C/T cg06096015 chr1:231504339 EGLN1 0.38 5.64 0.3 3.66e-8 Hemoglobin concentration; CRC cis rs17401966 0.522 rs946504 chr1:10308597 T/C cg19773385 chr1:10388646 KIF1B -0.49 -7.86 -0.4 5.57e-14 Hepatocellular carcinoma; CRC cis rs7274811 0.711 rs291691 chr20:32002878 G/C cg03904042 chr20:32255491 NECAB3;C20orf134 0.41 5.8 0.3 1.59e-8 Height; CRC cis rs7626444 0.584 rs844542 chr3:196479303 C/T cg12930392 chr3:196481615 PAK2 0.4 7.26 0.37 2.73e-12 Monocyte count; CRC cis rs9560113 0.573 rs9560133 chr13:112240013 C/A cg10483660 chr13:112241077 NA 0.66 13.02 0.58 1.5e-31 Menarche (age at onset); CRC cis rs9611565 0.729 rs73176686 chr22:41782119 C/T cg03806693 chr22:41940476 POLR3H -1.07 -13.42 -0.59 4.59e-33 Vitiligo; CRC cis rs2252790 1.000 rs13214667 chr6:116637440 G/A cg18764771 chr6:116381957 FRK 0.22 5.75 0.3 2e-8 Fast beta electroencephalogram; CRC cis rs2073300 0.609 rs17830281 chr20:23350525 C/T cg12062639 chr20:23401060 NAPB 0.7 6.3 0.33 9.27e-10 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs10256972 0.524 rs6945202 chr7:1116558 T/C cg18402987 chr7:1209562 NA 0.46 6.78 0.35 5.72e-11 Longevity;Endometriosis; CRC cis rs2243480 1.000 rs34970380 chr7:65431493 C/T cg18252515 chr7:66147081 NA -1.06 -12.17 -0.56 2.23e-28 Diabetic kidney disease; CRC cis rs6951245 1.000 rs113066613 chr7:1094128 T/C cg24642844 chr7:1081250 C7orf50 -0.78 -9.47 -0.46 5.57e-19 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs765787 0.530 rs4775844 chr15:45542048 T/C cg24006582 chr15:45444508 DUOX1 -0.57 -8.62 -0.43 2.8e-16 Uric acid levels; CRC cis rs7224685 0.501 rs781848 chr17:3958105 A/C cg11204139 chr17:3907470 NA 0.74 13.07 0.58 1.01e-31 Type 2 diabetes; CRC cis rs35110281 0.840 rs7276633 chr21:45078800 C/T cg04455712 chr21:45112962 RRP1B 0.41 7.99 0.4 2.23e-14 Mean corpuscular volume; CRC trans rs4650994 1.000 rs4650994 chr1:178515312 A/G cg05059571 chr16:84539110 KIAA1609 0.46 7.0 0.36 1.46e-11 HDL cholesterol levels;HDL cholesterol; CRC cis rs8180040 0.620 rs6768722 chr3:47079112 G/A cg27129171 chr3:47204927 SETD2 0.73 11.53 0.54 4.47e-26 Colorectal cancer; CRC cis rs10504229 0.654 rs903705 chr8:58128185 T/A cg21724239 chr8:58056113 NA 0.49 6.81 0.35 4.75e-11 Developmental language disorder (linguistic errors); CRC cis rs7224685 0.501 rs781823 chr17:3966280 G/C cg09597638 chr17:3907349 NA 0.64 11.62 0.54 2.26e-26 Type 2 diabetes; CRC cis rs11190604 1.000 rs2495754 chr10:102324812 C/T cg16342193 chr10:102329863 NA -0.36 -5.93 -0.31 7.82e-9 Palmitoleic acid (16:1n-7) levels; CRC cis rs4481887 0.741 rs28616194 chr1:248531904 T/A cg00666640 chr1:248458726 OR2T12 0.43 7.64 0.39 2.34e-13 Common traits (Other); CRC cis rs3849570 0.673 rs13068700 chr3:81975817 G/C cg07356753 chr3:81810745 GBE1 -0.58 -8.0 -0.4 2.18e-14 Waist circumference;Body mass index; CRC cis rs41005 0.805 rs10469618 chr2:8117622 C/T cg03155496 chr2:8117019 LOC339788 -0.41 -7.37 -0.38 1.37e-12 Response to anti-TNF therapy in rheumatoid arthritis; CRC cis rs1448094 0.967 rs7978132 chr12:86323484 T/C cg02569458 chr12:86230093 RASSF9 0.37 6.47 0.34 3.47e-10 Major depressive disorder; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg04407579 chr13:99228509 STK24 -0.41 -6.34 -0.33 7.39e-10 Myopia (pathological); CRC cis rs6570726 0.791 rs9403729 chr6:145907007 C/T cg23711669 chr6:146136114 FBXO30 0.77 13.31 0.59 1.28e-32 Lobe attachment (rater-scored or self-reported); CRC cis rs4523957 0.820 rs9908972 chr17:2103810 A/C cg16513277 chr17:2031491 SMG6 -0.52 -8.63 -0.43 2.58e-16 Autism spectrum disorder or schizophrenia;Schizophrenia; CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg27301249 chr20:44718793 NCOA5 -0.51 -6.25 -0.33 1.28e-9 Diisocyanate-induced asthma; CRC cis rs854572 0.600 rs705382 chr7:94955221 C/G cg04871131 chr7:94954202 PON1 -0.6 -9.53 -0.47 3.66e-19 Paraoxonase activity; CRC cis rs1519814 1.000 rs7000103 chr8:121166200 A/C cg22335954 chr8:121166405 COL14A1 -0.59 -6.84 -0.35 3.81e-11 Breast cancer; CRC cis rs78545713 0.536 rs80202565 chr6:26233882 C/G cg16070018 chr6:26224392 HIST1H3E 0.67 5.69 0.3 2.76e-8 Iron status biomarkers (total iron binding capacity); CRC cis rs7586879 0.964 rs13412941 chr2:25102709 C/T cg22495460 chr2:25135724 ADCY3 -0.88 -15.15 -0.64 1.04e-39 Body mass index; CRC cis rs6546537 0.562 rs1985342 chr2:69758927 C/T cg10773587 chr2:69614142 GFPT1 -0.47 -6.29 -0.33 1.01e-9 Serum thyroid-stimulating hormone levels; CRC trans rs6601327 0.606 rs7006985 chr8:9564437 A/G cg06636001 chr8:8085503 FLJ10661 -0.46 -6.66 -0.34 1.12e-10 Multiple myeloma (hyperdiploidy); CRC cis rs9467711 0.659 rs72844462 chr6:26563864 A/C cg08501292 chr6:25962987 TRIM38 0.88 6.11 0.32 2.84e-9 Autism spectrum disorder or schizophrenia; CRC cis rs763121 0.853 rs8138996 chr22:39047435 G/T cg06544989 chr22:39130855 UNC84B 0.44 6.84 0.35 3.76e-11 Menopause (age at onset); CRC cis rs11583043 0.874 rs11578366 chr1:101396852 T/A cg16556008 chr1:101360663 SLC30A7;EXTL2 0.57 7.73 0.39 1.35e-13 Ulcerative colitis;Inflammatory bowel disease; CRC cis rs7394190 0.748 rs11000777 chr10:75545063 G/C cg07699608 chr10:75541558 CHCHD1 0.61 6.38 0.33 5.97e-10 Incident atrial fibrillation; CRC cis rs3785574 0.962 rs2584623 chr17:61906679 G/A cg25654072 chr17:61904446 PSMC5;FTSJ3 0.44 6.01 0.31 4.82e-9 Height; CRC cis rs35883536 0.647 rs12026951 chr1:101046273 C/T cg06223162 chr1:101003688 GPR88 -0.35 -6.31 -0.33 8.77e-10 Monocyte count; CRC trans rs2303319 0.504 rs55782047 chr2:162440255 A/C cg18122310 chr12:50236657 BCDIN3D -0.74 -6.21 -0.32 1.64e-9 Cognitive function; CRC cis rs13118159 0.527 rs1250119 chr4:1261336 G/A cg19318889 chr4:1322082 MAEA -0.69 -9.82 -0.48 3.99e-20 Longevity; CRC cis rs990171 0.955 rs3817465 chr2:103039584 A/T cg03938978 chr2:103052716 IL18RAP 0.46 5.78 0.3 1.69e-8 Lymphocyte counts; CRC cis rs4711336 0.967 rs4713658 chr6:33667117 C/G cg14003231 chr6:33640908 ITPR3 0.44 7.0 0.36 1.44e-11 Height; CRC cis rs7224685 0.501 rs8066272 chr17:3900528 C/T cg05562828 chr17:3906858 NA 0.73 13.99 0.61 3.12e-35 Type 2 diabetes; CRC trans rs1997103 0.911 rs10238738 chr7:55412359 T/C cg20935933 chr6:143382018 AIG1 0.49 6.46 0.34 3.8e-10 QRS interval (sulfonylurea treatment interaction); CRC cis rs7618915 0.547 rs2164884 chr3:52629633 C/T cg11645453 chr3:52864694 ITIH4 0.35 6.13 0.32 2.58e-9 Bipolar disorder; CRC cis rs2762353 0.595 rs1892256 chr6:25754271 C/T cg12310025 chr6:25882481 NA 0.74 10.47 0.5 2.54e-22 Blood metabolite levels; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg25346583 chr19:16296095 FAM32A 0.52 7.66 0.39 2.07e-13 Intelligence (multi-trait analysis); CRC trans rs116095464 0.558 rs10043002 chr5:226753 G/A cg00938859 chr5:1591904 SDHAP3 0.72 7.89 0.4 4.54e-14 Breast cancer; CRC cis rs6764363 0.527 rs13060510 chr3:279638 T/A cg02057681 chr3:285234 CHL1 0.42 7.12 0.37 6.65e-12 Sudden cardiac arrest; CRC cis rs1005277 0.522 rs1208767 chr10:38042295 G/T cg25517755 chr10:38738941 LOC399744 -0.45 -6.49 -0.34 3.25e-10 Extrinsic epigenetic age acceleration; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg07208322 chr5:177027175 B4GALT7 0.45 6.37 0.33 6.31e-10 Anxiety disorder; CRC cis rs10504229 0.683 rs11785258 chr8:58132893 A/G cg21724239 chr8:58056113 NA 0.49 6.81 0.35 4.75e-11 Developmental language disorder (linguistic errors); CRC cis rs9393692 0.905 rs9357004 chr6:26303319 A/G cg13736514 chr6:26305472 NA -0.58 -11.02 -0.52 3e-24 Educational attainment; CRC cis rs1707322 1.000 rs11211237 chr1:46447329 G/C cg06784218 chr1:46089804 CCDC17 0.51 8.96 0.44 2.39e-17 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs17401966 1.000 rs2275424 chr1:10356562 C/A cg19773385 chr1:10388646 KIF1B -0.57 -7.89 -0.4 4.53e-14 Hepatocellular carcinoma; CRC cis rs7193541 0.646 rs4888267 chr16:74687906 A/G cg01733217 chr16:74700730 RFWD3 1.05 21.76 0.77 1.12e-65 Multiple myeloma; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg02184338 chr7:101331866 NA 0.43 6.97 0.36 1.72e-11 Liver disease severity in Alagille syndrome; CRC cis rs7618915 0.547 rs11709448 chr3:52647449 T/C cg08222913 chr3:52553049 STAB1 -0.34 -6.15 -0.32 2.2e-9 Bipolar disorder; CRC cis rs7107770 1.000 rs35183670 chr11:125090912 G/A cg27629782 chr11:125073726 PKNOX2 0.48 5.82 0.31 1.39e-8 Photic sneeze reflex; CRC cis rs12580194 0.593 rs67934812 chr12:55785591 T/G cg19537932 chr12:55886519 OR6C68 -0.72 -9.08 -0.45 9.94e-18 Cancer; CRC cis rs4665809 0.590 rs6730310 chr2:26419470 C/G cg08067268 chr2:26466485 HADHB;HADHA -0.66 -8.23 -0.41 4.36e-15 Gut microbiome composition (summer); CRC cis rs6088580 0.634 rs6059875 chr20:33086090 T/G cg24642439 chr20:33292090 TP53INP2 0.41 6.7 0.35 9.29e-11 Glomerular filtration rate (creatinine); CRC cis rs10256972 0.552 rs2960830 chr7:1200641 T/C cg26608667 chr7:1196370 ZFAND2A 0.42 6.85 0.35 3.54e-11 Longevity;Endometriosis; CRC cis rs4901869 0.902 rs2162491 chr14:59296247 C/T cg02291164 chr14:59296302 NA 0.39 7.36 0.38 1.45e-12 Panic disorder; CRC cis rs3806843 1.000 rs3733708 chr5:140181734 A/G cg19875535 chr5:140030758 IK 0.6 9.85 0.48 3.25e-20 Depressive symptoms (multi-trait analysis); CRC cis rs780096 0.526 rs780107 chr2:27684734 A/G cg02592271 chr2:27665507 KRTCAP3 -0.28 -6.58 -0.34 1.83e-10 Total body bone mineral density; CRC cis rs9393692 0.620 rs9357005 chr6:26336838 C/A cg13736514 chr6:26305472 NA -0.47 -7.63 -0.39 2.5e-13 Educational attainment; CRC cis rs2976388 0.609 rs2572904 chr8:143792193 A/C cg20041105 chr8:143859282 LYNX1 0.46 8.24 0.41 4.25e-15 Urinary tract infection frequency; CRC cis rs4665809 0.652 rs6728090 chr2:26524726 C/T cg26119090 chr2:26468346 HADHA;HADHB -0.8 -11.28 -0.53 3.58e-25 Gut microbiome composition (summer); CRC cis rs7208859 0.623 rs73269945 chr17:29108759 G/A cg01831904 chr17:28903510 LRRC37B2 -0.63 -6.45 -0.33 4.07e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs12908161 0.959 rs17598603 chr15:85200211 C/G cg11189052 chr15:85197271 WDR73 -0.63 -8.99 -0.44 2.05e-17 Schizophrenia; CRC cis rs4713118 0.513 rs156738 chr6:28014025 G/C cg20615401 chr6:28092323 ZSCAN16 0.46 6.14 0.32 2.33e-9 Parkinson's disease; CRC cis rs12476592 0.543 rs10170988 chr2:63650582 T/C cg10828910 chr2:63850056 LOC388955 0.52 6.26 0.33 1.19e-9 Childhood ear infection; CRC cis rs17092148 0.790 rs6058079 chr20:33142873 G/A cg08999081 chr20:33150536 PIGU 0.5 6.44 0.33 4.27e-10 Neuroticism; CRC cis rs35883536 0.609 rs2647327 chr1:101041766 C/T cg06223162 chr1:101003688 GPR88 0.33 5.84 0.31 1.26e-8 Monocyte count; CRC cis rs6748734 0.625 rs6437372 chr2:241822406 A/G cg16358738 chr2:241808595 AGXT 0.38 6.64 0.34 1.27e-10 Urinary metabolites; CRC cis rs881375 0.967 rs758959 chr9:123676699 C/T cg09419670 chr9:123605666 PSMD5;LOC253039 0.59 8.67 0.43 2.06e-16 Rheumatoid arthritis; CRC cis rs9326248 1.000 rs664971 chr11:117070857 A/G cg11861562 chr11:117069780 TAGLN -0.42 -9.48 -0.46 5.05e-19 Blood protein levels; CRC cis rs6866344 0.697 rs17184302 chr5:178127676 C/T cg03877680 chr5:178157825 ZNF354A 0.77 10.96 0.52 4.9299999999999996e-24 Neutrophil percentage of white cells; CRC cis rs7703744 0.634 rs3797340 chr5:118691737 C/G cg17471836 chr5:118691007 TNFAIP8 0.43 6.07 0.32 3.53e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs367943 1.000 rs348925 chr5:112817533 T/A cg12552261 chr5:112820674 MCC -0.5 -7.79 -0.39 9.07e-14 Type 2 diabetes; CRC cis rs896854 0.654 rs896846 chr8:95972453 G/A cg16049864 chr8:95962084 TP53INP1 -0.65 -11.83 -0.55 3.9e-27 Type 2 diabetes; CRC cis rs9318086 0.578 rs2077709 chr13:24476073 A/G cg25267304 chr13:24462978 PCOTH;MIPEP -0.6 -9.23 -0.45 3.42e-18 Myopia (pathological); CRC cis rs5753618 0.561 rs9606830 chr22:31717799 T/G cg07713946 chr22:31675144 LIMK2 0.4 5.74 0.3 2.16e-8 Colorectal cancer; CRC cis rs2734839 0.929 rs2734835 chr11:113291343 T/G cg14159747 chr11:113255604 NA 0.48 8.57 0.43 4.01e-16 Information processing speed; CRC cis rs11190604 1.000 rs11190604 chr10:102302457 A/G cg16342193 chr10:102329863 NA -0.37 -6.01 -0.31 5.06e-9 Palmitoleic acid (16:1n-7) levels; CRC cis rs9733 0.650 rs11204680 chr1:150587140 T/G cg18016565 chr1:150552671 MCL1 -0.47 -7.0 -0.36 1.46e-11 Tonsillectomy; CRC cis rs1223397 0.524 rs2496152 chr6:13314547 A/G cg07912922 chr6:13274314 PHACTR1 0.36 5.69 0.3 2.83e-8 Blood pressure; CRC cis rs8177253 1.000 rs8177271 chr3:133482230 G/A cg08048268 chr3:133502702 NA -0.37 -6.92 -0.36 2.34e-11 Iron status biomarkers; CRC cis rs651907 0.557 rs11917682 chr3:101355427 G/A cg12386194 chr3:101231763 SENP7 0.48 6.86 0.35 3.45e-11 Colorectal cancer; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg18756060 chr2:27294719 LOC100128731 0.45 6.33 0.33 8.25e-10 Anxiety disorder; CRC cis rs7772486 0.875 rs1929523 chr6:146339989 T/A cg23711669 chr6:146136114 FBXO30 0.67 11.53 0.54 4.5e-26 Lobe attachment (rater-scored or self-reported); CRC cis rs1707322 0.752 rs28545085 chr1:46201950 G/A cg06784218 chr1:46089804 CCDC17 0.65 12.05 0.55 5.8e-28 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs394563 0.775 rs448420 chr6:149785802 T/C cg11245181 chr6:149772854 ZC3H12D -0.59 -9.85 -0.48 3.17e-20 Dupuytren's disease; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg20312087 chr8:145754193 MGC70857 0.38 6.09 0.32 3.19e-9 Liver disease severity in Alagille syndrome; CRC cis rs6582630 0.502 rs1915395 chr12:38420726 A/G cg26384229 chr12:38710491 ALG10B 0.69 9.19 0.45 4.54e-18 Drug-induced liver injury (flucloxacillin); CRC cis rs77106637 0.932 rs3814730 chr11:72555553 G/A cg03713592 chr11:72463424 ARAP1 0.72 7.09 0.36 8.19e-12 Type 2 diabetes; CRC trans rs4332037 0.539 rs56016347 chr7:2060126 C/T cg11693508 chr17:37793320 STARD3 0.6 7.04 0.36 1.15e-11 Bipolar disorder; CRC cis rs2811415 0.597 rs9827421 chr3:127775499 C/T cg13719885 chr3:127795394 NA -0.39 -5.95 -0.31 6.69e-9 Lung function (FEV1/FVC); CRC cis rs7512552 0.646 rs1694367 chr1:150329469 T/A cg15654264 chr1:150340011 RPRD2 0.59 8.59 0.43 3.42e-16 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); CRC cis rs853679 0.517 rs9368553 chr6:28082265 T/C cg15786705 chr6:28176104 NA 0.76 9.47 0.46 5.57e-19 Depression; CRC cis rs7666738 0.830 rs4699601 chr4:99034429 G/A cg17366294 chr4:99064904 C4orf37 0.44 7.47 0.38 7.18e-13 Colonoscopy-negative controls vs population controls; CRC cis rs9611565 0.694 rs202631 chr22:41863423 A/G cg06634786 chr22:41940651 POLR3H 0.58 7.08 0.36 8.82e-12 Vitiligo; CRC cis rs877282 0.945 rs11253397 chr10:789774 A/G cg17470449 chr10:769945 NA 0.68 9.03 0.45 1.48e-17 Uric acid levels; CRC cis rs6912958 0.781 rs9450732 chr6:88249826 G/A cg08069147 chr6:88032118 GJB7;C6orf162 -0.56 -8.43 -0.42 1.12e-15 Monocyte percentage of white cells; CRC cis rs28386778 0.897 rs2665832 chr17:61912261 C/T cg23090583 chr17:61904693 PSMC5;FTSJ3 1.05 20.56 0.75 5.48e-61 Prudent dietary pattern; CRC cis rs4563143 0.514 rs112540771 chr19:29316100 C/T cg03161606 chr19:29218774 NA 0.54 6.38 0.33 5.85e-10 Methadone dose in opioid dependence; CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg16956456 chr5:172483378 C5orf41 -0.51 -6.27 -0.33 1.12e-9 Diisocyanate-induced asthma; CRC cis rs7618915 0.501 rs34739010 chr3:52766122 A/G cg18099408 chr3:52552593 STAB1 -0.47 -7.89 -0.4 4.59e-14 Bipolar disorder; CRC cis rs7312774 0.881 rs1822737 chr12:107309175 A/G cg16260113 chr12:107380972 MTERFD3 0.71 7.18 0.37 4.79e-12 Severe influenza A (H1N1) infection; CRC cis rs17767392 0.881 rs10138557 chr14:72061718 C/T cg13720639 chr14:72061746 SIPA1L1 0.56 7.1 0.36 7.55e-12 Mitral valve prolapse; CRC cis rs10504073 0.669 rs818559 chr8:50035806 C/T cg00325661 chr8:49890786 NA 0.46 8.23 0.41 4.37e-15 Blood metabolite ratios; CRC cis rs1552244 0.882 rs68080705 chr3:10025743 C/T cg13047869 chr3:10149882 C3orf24 0.5 6.68 0.35 1.02e-10 Alzheimer's disease; CRC cis rs950169 0.881 rs62029599 chr15:84956565 A/C cg11189052 chr15:85197271 WDR73 0.63 8.8 0.44 7.65e-17 Schizophrenia; CRC cis rs3741151 0.892 rs7105705 chr11:73012319 T/G cg17517138 chr11:73019481 ARHGEF17 0.69 7.26 0.37 2.85e-12 GIP levels in response to oral glucose tolerance test (120 minutes); CRC cis rs9660180 0.868 rs12567685 chr1:1806647 T/C cg23982607 chr1:1823379 GNB1 -0.91 -17.02 -0.68 4.88e-47 Body mass index; CRC cis rs3733585 0.753 rs1122141 chr4:9947278 T/C cg11266682 chr4:10021025 SLC2A9 -0.48 -9.48 -0.46 5.24e-19 Cleft plate (environmental tobacco smoke interaction); CRC cis rs9916302 0.851 rs11078904 chr17:37650569 G/A cg15445000 chr17:37608096 MED1 0.43 9.5 0.46 4.37e-19 Glomerular filtration rate (creatinine); CRC cis rs2274273 0.624 rs7150234 chr14:55802181 A/G cg10130446 chr14:55658398 DLGAP5 -0.44 -6.16 -0.32 2.12e-9 Protein biomarker; CRC cis rs7131987 0.868 rs737160 chr12:29429012 T/C cg09582351 chr12:29534625 ERGIC2 -0.3 -6.4 -0.33 5.48e-10 QT interval; CRC cis rs6540559 1.000 rs17015259 chr1:209982923 G/A cg21951975 chr1:209979733 IRF6 0.43 6.66 0.34 1.14e-10 Cleft lip with or without cleft palate; CRC cis rs4481887 1.000 rs4593862 chr1:248480176 G/T cg00666640 chr1:248458726 OR2T12 0.55 9.56 0.47 2.9e-19 Common traits (Other); CRC cis rs62229266 0.804 rs2835263 chr21:37430245 A/G cg08632701 chr21:37451849 NA 0.46 7.24 0.37 3.11e-12 Mitral valve prolapse; CRC cis rs372883 0.580 rs2254038 chr21:30745722 C/T cg24692254 chr21:30365293 RNF160 0.57 8.81 0.44 7.4e-17 Pancreatic cancer; CRC cis rs1964356 0.524 rs7839585 chr8:8854235 C/G cg06636001 chr8:8085503 FLJ10661 -0.38 -5.66 -0.3 3.31e-8 Mean corpuscular volume; CRC trans rs3118914 1.000 rs3116603 chr13:51112122 G/C cg09222023 chr3:138669322 C3orf72 0.35 6.0 0.31 5.18e-9 Height; CRC cis rs7923609 0.967 rs2393966 chr10:65134814 T/G cg08743896 chr10:65200160 JMJD1C -0.4 -5.76 -0.3 1.98e-8 Educational attainment;Liver enzyme levels (alkaline phosphatase); CRC cis rs12760731 0.720 rs11805590 chr1:178308911 A/G cg00404053 chr1:178313656 RASAL2 0.87 9.55 0.47 3.1e-19 Obesity-related traits; CRC cis rs11758351 1.000 rs77961951 chr6:26186075 A/G cg16070018 chr6:26224392 HIST1H3E 0.6 5.82 0.31 1.38e-8 Gout;Renal underexcretion gout; CRC cis rs6502050 0.805 rs9898326 chr17:80119582 C/T cg13198984 chr17:80129470 CCDC57 0.47 8.35 0.42 1.88e-15 Life satisfaction; CRC cis rs7959452 0.557 rs899224 chr12:69784774 A/G cg14784868 chr12:69753453 YEATS4 0.84 14.68 0.63 7.14e-38 Blood protein levels; CRC cis rs4819052 0.851 rs9754134 chr21:46661751 T/C cg11663144 chr21:46675770 NA -0.83 -14.12 -0.61 9.88e-36 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs4272382 1 rs4272382 chr8:8433488 C/T cg19996406 chr8:8318774 NA 0.43 5.77 0.3 1.88e-8 Response to cytidine analogues (gemcitabine); CRC trans rs6951245 0.554 rs76243429 chr7:1152543 C/T cg13565492 chr6:43139072 SRF -0.83 -10.39 -0.5 4.76e-22 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs17711722 0.653 rs2460421 chr7:65491123 A/T cg11764359 chr7:65958608 NA -0.43 -6.2 -0.32 1.65e-9 Calcium levels; CRC cis rs2463822 0.748 rs2513053 chr11:62109473 T/A cg06239285 chr11:62104954 ASRGL1 0.97 11.41 0.53 1.27e-25 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs12745968 0.589 rs10874727 chr1:93103152 T/C cg17283838 chr1:93427260 FAM69A -0.45 -6.18 -0.32 1.94e-9 Bipolar disorder and schizophrenia; CRC cis rs1692580 0.682 rs12045693 chr1:2205581 A/C cg21194808 chr1:2205498 SKI -0.42 -6.76 -0.35 6.42e-11 Coronary artery disease; CRC cis rs4731207 0.564 rs12531996 chr7:124619460 T/C cg23710748 chr7:124431027 NA -0.4 -6.23 -0.32 1.46e-9 Cutaneous malignant melanoma; CRC cis rs7586879 0.796 rs36071142 chr2:25080570 C/T cg04586622 chr2:25135609 ADCY3 -0.55 -9.37 -0.46 1.22e-18 Body mass index; CRC cis rs798554 0.679 rs1639036 chr7:2885089 G/A cg13628971 chr7:2884303 GNA12 0.61 8.62 0.43 2.94e-16 Height; CRC cis rs514406 0.760 rs1242198 chr1:53352016 G/A cg27535305 chr1:53392650 SCP2 -0.38 -6.85 -0.35 3.62e-11 Monocyte count; CRC cis rs7914558 1.000 rs11191539 chr10:104819770 A/G cg15744005 chr10:104629667 AS3MT -0.33 -7.06 -0.36 9.89e-12 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs72945132 0.882 rs56368270 chr11:70162590 A/G cg00319359 chr11:70116639 PPFIA1 0.66 6.9 0.36 2.62e-11 Coronary artery disease; CRC cis rs12760731 0.641 rs10047148 chr1:178250266 T/C cg00404053 chr1:178313656 RASAL2 0.96 10.07 0.49 5.59e-21 Obesity-related traits; CRC cis rs13118159 0.801 rs7664474 chr4:1329116 T/A cg02018176 chr4:1364513 KIAA1530 0.43 7.03 0.36 1.2e-11 Longevity; CRC cis rs3749237 0.595 rs7643845 chr3:49530711 A/G cg03060546 chr3:49711283 APEH 0.69 11.99 0.55 1.02e-27 Resting heart rate; CRC cis rs6582630 0.555 rs10880421 chr12:38423015 C/T cg26384229 chr12:38710491 ALG10B 0.69 9.19 0.45 4.54e-18 Drug-induced liver injury (flucloxacillin); CRC cis rs12142240 0.698 rs68012736 chr1:46839510 A/G cg00530320 chr1:46809349 NSUN4 0.6 8.14 0.41 8.41e-15 Menopause (age at onset); CRC cis rs9549328 0.800 rs1317507 chr13:113631780 G/T cg08614441 chr13:113633676 MCF2L -0.52 -9.27 -0.46 2.54e-18 Systolic blood pressure; CRC cis rs17253792 0.822 rs8013831 chr14:56172898 G/A cg01858014 chr14:56050164 KTN1 -0.71 -6.92 -0.36 2.4e-11 Putamen volume; CRC cis rs6952809 0.532 rs6461361 chr7:2432167 A/G cg23289794 chr7:2394357 EIF3B -0.79 -9.76 -0.47 6.29e-20 Multiple sclerosis; CRC cis rs1223397 1.000 rs1232392 chr6:13272671 C/G cg06879394 chr6:13274151 PHACTR1 0.55 6.63 0.34 1.39e-10 Blood pressure; CRC cis rs10878977 0.542 rs9645827 chr12:69814495 G/A cg20891283 chr12:69753455 YEATS4 -0.6 -5.92 -0.31 8.13e-9 Colorectal cancer; CRC cis rs9905704 0.918 rs12942969 chr17:56892872 A/T cg12560992 chr17:57184187 TRIM37 0.53 7.22 0.37 3.69e-12 Testicular germ cell tumor; CRC cis rs6723226 0.721 rs10172510 chr2:32620888 A/G cg02381751 chr2:32503542 YIPF4 0.52 7.72 0.39 1.45e-13 Intelligence (multi-trait analysis); CRC cis rs7814319 0.674 rs2292835 chr8:97243720 G/A cg20787634 chr8:97240163 UQCRB -0.45 -7.32 -0.37 1.97e-12 Lung function (FVC); CRC cis rs561341 1.000 rs7214017 chr17:30332220 T/C cg12193833 chr17:30244370 NA -0.63 -7.95 -0.4 3.01e-14 Hip circumference adjusted for BMI; CRC cis rs1129187 0.755 rs9462856 chr6:42926024 T/C cg02359409 chr6:42947317 PEX6 -0.65 -10.29 -0.49 1.06e-21 Alzheimer's disease in APOE e4+ carriers; CRC cis rs720844 0.882 rs7599758 chr2:149293880 C/T cg09247360 chr2:149335327 NA -0.55 -6.74 -0.35 7.22e-11 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs12519773 0.597 rs17360518 chr5:92457899 A/C cg18783429 chr5:92414398 NA 0.29 6.1 0.32 2.99e-9 Migraine; CRC cis rs6938 0.534 rs12913293 chr15:75184458 G/C cg17294928 chr15:75287854 SCAMP5 0.51 7.95 0.4 3.04e-14 Breast cancer; CRC cis rs62064224 0.589 rs756785 chr17:30812845 T/C cg18200150 chr17:30822561 MYO1D 0.48 9.64 0.47 1.54e-19 Schizophrenia; CRC cis rs1506636 0.511 rs62484466 chr7:123174880 T/A cg03229431 chr7:123269106 ASB15 0.46 6.53 0.34 2.42e-10 Plateletcrit;Platelet count; CRC cis rs6089584 0.888 rs2892060 chr20:60617955 G/T cg06108461 chr20:60628389 TAF4 -0.92 -15.9 -0.66 1.24e-42 Body mass index; CRC trans rs587242 1.000 rs552032 chr1:96895482 G/C cg10631902 chr5:14652156 NA 0.44 6.84 0.35 3.84e-11 Body mass index (joint analysis main effects and physical activity interaction);Body mass index in physically inactive individuals;Body mass index; CRC trans rs11039798 0.511 rs7948129 chr11:48167828 G/A cg15704280 chr7:45808275 SEPT13 -0.75 -8.02 -0.4 1.81e-14 Axial length; CRC trans rs7395662 0.591 rs12807777 chr11:48593754 A/T cg21153622 chr11:89784906 NA -0.52 -8.71 -0.43 1.46e-16 HDL cholesterol; CRC cis rs7666738 1.000 rs13124102 chr4:98990696 G/A cg05340658 chr4:99064831 C4orf37 0.53 7.66 0.39 2.08e-13 Colonoscopy-negative controls vs population controls; CRC cis rs1799949 0.965 rs8176198 chr17:41230537 A/T cg19454999 chr17:41278357 BRCA1;NBR2 0.39 5.91 0.31 8.74e-9 Menopause (age at onset); CRC cis rs2336384 1.000 rs7551874 chr1:12048130 A/G cg13216073 chr1:12042593 MFN2 0.48 7.02 0.36 1.26e-11 Platelet count; CRC cis rs2953145 0.568 rs2975752 chr2:241521327 A/G cg07929629 chr2:241523174 NA 0.67 9.85 0.48 3.15e-20 Bipolar disorder; CRC trans rs7618501 0.521 rs34654589 chr3:49911449 C/G cg21659725 chr3:3221576 CRBN 0.51 7.28 0.37 2.4e-12 Intelligence (multi-trait analysis); CRC cis rs2836754 1.000 rs2836754 chr21:40291740 C/T cg20434300 chr21:40194735 ETS2 0.35 6.12 0.32 2.73e-9 Crohn's disease;Body mass index; CRC cis rs6540559 1.000 rs17015259 chr1:209982923 G/A cg25204440 chr1:209979598 IRF6 0.5 7.08 0.36 8.78e-12 Cleft lip with or without cleft palate; CRC cis rs8037137 0.915 rs79548680 chr15:91505779 G/C cg23684204 chr15:91497937 RCCD1 0.51 5.6 0.3 4.43e-8 Platelet count;Serous invasive ovarian cancer;High-grade serous ovarian cancer;Invasive epithelial ovarian cancer; CRC cis rs4853012 0.838 rs72915068 chr2:74356185 G/A cg19729930 chr2:74357872 NA 0.72 11.02 0.52 2.94e-24 Gestational age at birth (maternal effect); CRC cis rs854765 0.547 rs9896837 chr17:17924868 A/G cg23957660 chr17:17878224 LRRC48 0.42 7.66 0.39 2.03e-13 Total body bone mineral density; CRC cis rs2019137 0.560 rs10175462 chr2:113988492 G/A cg02675527 chr2:114030824 PAX8;LOC440839 -0.4 -6.04 -0.32 4.17e-9 Lymphocyte counts; CRC cis rs11690935 0.589 rs6729945 chr2:172864695 C/G cg13550731 chr2:172543902 DYNC1I2 0.64 9.28 0.46 2.37e-18 Schizophrenia; CRC cis rs977987 0.778 rs2865528 chr16:75455942 T/C cg03315344 chr16:75512273 CHST6 0.52 8.82 0.44 6.97e-17 Dupuytren's disease; CRC cis rs9287719 0.967 rs10929682 chr2:10732189 C/A cg00105475 chr2:10696890 NA 0.45 7.28 0.37 2.43e-12 Prostate cancer; CRC trans rs4325129 1.000 rs7555008 chr1:159457808 T/C cg01965939 chr5:148442694 SH3TC2 -0.28 -6.04 -0.32 4.18e-9 Obesity-related traits; CRC cis rs763121 0.853 rs2284073 chr22:39105948 T/C cg06544989 chr22:39130855 UNC84B 0.49 7.78 0.39 9.32e-14 Menopause (age at onset); CRC cis rs9926296 0.605 rs8047486 chr16:89854025 A/T cg04287289 chr16:89883240 FANCA 0.81 14.4 0.62 8.66e-37 Vitiligo; CRC cis rs2066819 1.000 rs57279772 chr12:56698960 G/A cg26714650 chr12:56694279 CS -1.38 -11.56 -0.54 3.59e-26 Psoriasis vulgaris; CRC cis rs2764208 0.599 rs9368828 chr6:34661449 A/T cg07306190 chr6:34760872 UHRF1BP1 0.35 6.2 0.32 1.66e-9 Systemic lupus erythematosus; CRC cis rs67478160 0.619 rs3742365 chr14:104198251 A/G cg01849466 chr14:104193079 ZFYVE21 -0.52 -9.26 -0.45 2.65e-18 Schizophrenia; CRC cis rs9388451 0.805 rs1028481 chr6:126106573 G/T cg10911889 chr6:126070802 HEY2 0.39 5.92 0.31 7.99e-9 Brugada syndrome; CRC cis rs57221529 0.766 rs4081847 chr5:574072 C/T cg14541582 chr5:601475 NA -0.33 -6.51 -0.34 2.76e-10 Lung disease severity in cystic fibrosis; CRC cis rs7605827 0.930 rs6431696 chr2:15540009 C/A cg19274914 chr2:15703543 NA 0.4 5.94 0.31 7.2e-9 Educational attainment (years of education); CRC cis rs8044995 0.563 rs1110572 chr16:68396119 A/G cg05110241 chr16:68378359 PRMT7 -0.68 -6.99 -0.36 1.58e-11 Schizophrenia; CRC cis rs694739 0.734 rs663743 chr11:64107735 G/A cg23796481 chr11:64053134 BAD;GPR137 0.55 8.16 0.41 7.31e-15 Alopecia areata;Crohn's disease;Psoriasis vulgaris; CRC cis rs9768139 0.733 rs35016950 chr7:158118710 C/A cg23298862 chr7:158159286 PTPRN2 0.37 5.71 0.3 2.49e-8 Calcium levels; CRC cis rs597539 0.690 rs497149 chr11:68626639 A/T cg06112835 chr11:68658793 MRPL21 0.44 7.13 0.37 6.38e-12 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs3796352 1.000 rs11714876 chr3:53101640 C/G cg07884673 chr3:53033167 SFMBT1 -0.75 -6.24 -0.33 1.33e-9 Immune reponse to smallpox (secreted IL-2); CRC trans rs7395662 0.895 rs1121000 chr11:48711790 A/T cg21153622 chr11:89784906 NA -0.48 -7.72 -0.39 1.45e-13 HDL cholesterol; CRC cis rs4731207 0.967 rs2299902 chr7:124397814 G/T cg23710748 chr7:124431027 NA 0.39 6.26 0.33 1.18e-9 Cutaneous malignant melanoma; CRC cis rs57994353 0.865 rs13290734 chr9:139330701 G/A cg13611204 chr9:139324423 INPP5E -0.41 -5.78 -0.3 1.71e-8 Eosinophil counts;Cutaneous squamous cell carcinoma; CRC cis rs11764590 0.724 rs1533829 chr7:2082841 A/G cg23422044 chr7:1970798 MAD1L1 -0.42 -5.87 -0.31 1.07e-8 Neuroticism; CRC cis rs13108904 0.905 rs1732108 chr4:1276550 C/T cg00684032 chr4:1343700 KIAA1530 -0.42 -6.28 -0.33 1.08e-9 Obesity-related traits; CRC cis rs666930 0.967 rs637868 chr1:120257110 A/G cg19096424 chr1:120255104 PHGDH 0.4 5.92 0.31 8.3e-9 Breast cancer; CRC cis rs9287719 0.935 rs10803723 chr2:10722877 C/T cg00105475 chr2:10696890 NA 0.45 7.26 0.37 2.75e-12 Prostate cancer; CRC cis rs6696846 0.936 rs1042831 chr1:205043250 G/C cg03948781 chr1:205179583 DSTYK 0.42 5.86 0.31 1.1e-8 Red blood cell count; CRC cis rs938554 0.744 rs938558 chr4:9939205 G/A cg00071950 chr4:10020882 SLC2A9 0.42 6.36 0.33 6.85e-10 Blood metabolite levels; CRC cis rs965469 0.619 rs6037565 chr20:3330308 T/C cg25506879 chr20:3388711 C20orf194 -0.37 -5.76 -0.3 1.91e-8 IFN-related cytopenia; CRC cis rs394563 0.591 rs237018 chr6:149743930 A/G cg16235748 chr6:149772707 ZC3H12D -0.37 -6.86 -0.35 3.5e-11 Dupuytren's disease; CRC cis rs61677309 1.000 rs61706007 chr11:118167278 T/G cg06090739 chr11:118230722 UBE4A 0.41 5.67 0.3 3.21e-8 Lung cancer in ever smokers; CRC cis rs6540559 0.673 rs7550857 chr1:209956542 C/A cg25204440 chr1:209979598 IRF6 0.48 5.65 0.3 3.57e-8 Cleft lip with or without cleft palate; CRC cis rs950776 0.616 rs12901300 chr15:78892952 G/A cg06917634 chr15:78832804 PSMA4 0.53 8.1 0.41 1.05e-14 Sudden cardiac arrest; CRC cis rs270601 0.683 rs81598 chr5:131587960 C/G cg12564285 chr5:131593104 PDLIM4 0.55 9.59 0.47 2.26e-19 Acylcarnitine levels; CRC cis rs6951245 0.872 rs75493422 chr7:1072890 C/T cg08132940 chr7:1081526 C7orf50 -0.54 -5.65 -0.3 3.52e-8 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs4713675 0.584 rs2966 chr6:33689520 C/T cg14003231 chr6:33640908 ITPR3 0.49 8.02 0.4 1.85e-14 Plateletcrit; CRC trans rs877282 1.000 rs71491304 chr10:772982 C/T cg22713356 chr15:30763199 NA 1.15 14.73 0.63 4.62e-38 Uric acid levels; CRC trans rs10242455 0.571 rs11734 chr7:99229768 C/G cg09045935 chr12:6379348 NA -0.77 -6.19 -0.32 1.8e-9 Blood metabolite levels; CRC trans rs3780486 0.846 rs2209948 chr9:33138247 G/A cg04842962 chr6:43655489 MRPS18A 1.16 23.69 0.79 4.09e-73 IgG glycosylation; CRC cis rs2290159 0.800 rs9817675 chr3:12676113 C/T cg23032965 chr3:12705835 RAF1 0.47 6.38 0.33 6.16e-10 Cholesterol, total; CRC cis rs6543140 0.865 rs6760275 chr2:103079607 C/T cg09003973 chr2:102972529 NA 0.41 5.83 0.31 1.33e-8 Blood protein levels; CRC cis rs4332037 0.851 rs34040190 chr7:1920356 G/A cg23422044 chr7:1970798 MAD1L1 -0.64 -7.8 -0.39 8.43e-14 Bipolar disorder; CRC cis rs2239547 0.657 rs12496077 chr3:52886241 G/A cg18404041 chr3:52824283 ITIH1 -0.4 -7.41 -0.38 1.09e-12 Schizophrenia; CRC cis rs941873 0.805 rs10824747 chr10:81118464 T/C cg09469691 chr10:81107165 PPIF 0.51 7.88 0.4 4.68e-14 Height; CRC cis rs8130944 0.859 rs11700836 chr21:44112463 A/G cg23590273 chr21:44105265 PDE9A -0.35 -5.62 -0.3 3.99e-8 Perceived unattractiveness to mosquitoes; CRC cis rs4808199 0.895 rs8105094 chr19:19374061 C/T cg03709012 chr19:19516395 GATAD2A 0.97 11.21 0.53 6.56e-25 Nonalcoholic fatty liver disease; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg06557630 chr16:49889701 NA 0.38 6.95 0.36 1.99e-11 Liver disease severity in Alagille syndrome; CRC cis rs910316 1.000 rs12889472 chr14:75543979 A/G cg08847533 chr14:75593920 NEK9 0.93 17.54 0.7 4.25e-49 Height; CRC cis rs9326248 1.000 rs3736120 chr11:117032125 G/T cg20608306 chr11:116969690 SIK3 0.29 5.72 0.3 2.43e-8 Blood protein levels; CRC cis rs4727027 0.865 rs13236754 chr7:148845773 G/A cg12479418 chr7:148823350 ZNF425;ZNF398 0.44 5.88 0.31 1.03e-8 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC trans rs1005277 0.602 rs1740743 chr10:38519222 C/T cg27523141 chr10:43048294 ZNF37B 0.47 6.9 0.36 2.69e-11 Extrinsic epigenetic age acceleration; CRC cis rs736801 0.740 rs17622378 chr5:131778452 A/G cg12564285 chr5:131593104 PDLIM4 0.33 5.74 0.3 2.15e-8 Breast cancer;Mosquito bite size; CRC cis rs2806561 0.765 rs652706 chr1:23514246 G/A cg12483005 chr1:23474871 LUZP1 0.49 7.13 0.37 6.42e-12 Height; CRC cis rs9894429 0.646 rs12603868 chr17:79618834 G/C cg09655341 chr17:79618100 PDE6G -0.37 -6.19 -0.32 1.77e-9 Eye color traits; CRC cis rs12530845 0.673 rs4269479 chr7:135332379 C/T cg23117316 chr7:135346802 PL-5283 -0.45 -5.82 -0.31 1.38e-8 Red blood cell traits; CRC cis rs7726839 0.574 rs11134149 chr5:637277 A/G cg14541582 chr5:601475 NA -0.32 -7.05 -0.36 1.05e-11 Obesity-related traits; CRC cis rs11628318 0.614 rs7145737 chr14:103121784 T/A cg12046867 chr14:103022105 NA 0.76 9.03 0.45 1.44e-17 Platelet count; CRC cis rs9311474 0.652 rs352158 chr3:52217704 C/T cg18099408 chr3:52552593 STAB1 -0.36 -5.94 -0.31 7.31e-9 Electroencephalogram traits; CRC cis rs9469578 0.636 rs16869463 chr6:33714983 A/G cg18708504 chr6:33715942 IP6K3 -0.49 -6.03 -0.32 4.28e-9 Phosphorus levels; CRC cis rs1348850 0.837 rs4243388 chr2:178284604 T/G cg02961200 chr2:178257176 LOC100130691;AGPS 0.62 9.3 0.46 1.98e-18 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs12190007 0.508 rs6605539 chr6:169731997 A/T cg16388071 chr6:169726476 NA 0.46 7.08 0.36 8.72e-12 Obesity-related traits; CRC cis rs4891159 0.790 rs77878087 chr18:74116337 G/A cg24786174 chr18:74118243 ZNF516 -0.9 -16.29 -0.67 3.61e-44 Longevity; CRC cis rs4237845 0.537 rs7969844 chr12:58278271 C/T cg00677455 chr12:58241039 CTDSP2 0.77 11.46 0.53 8.33e-26 Intelligence (multi-trait analysis); CRC cis rs1153858 1.000 rs4774579 chr15:45651803 G/A cg21132104 chr15:45694354 SPATA5L1 0.6 8.87 0.44 4.85e-17 Homoarginine levels; CRC trans rs8073060 0.586 rs6505484 chr17:33993152 G/A cg19694781 chr19:47549865 TMEM160 -1.07 -14.92 -0.64 8.66e-39 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; CRC cis rs7258465 0.965 rs1560118 chr19:18570035 G/A cg10790698 chr19:18539756 SSBP4 -0.43 -8.19 -0.41 5.83e-15 Breast cancer; CRC cis rs11098499 0.530 rs114866537 chr4:120258608 A/T cg24375607 chr4:120327624 NA 0.47 7.68 0.39 1.83e-13 Corneal astigmatism; CRC cis rs12541635 0.677 rs6469026 chr8:107006356 T/C cg10147462 chr8:107024639 NA 0.57 9.51 0.46 4.12e-19 Age of smoking initiation; CRC cis rs7493 0.853 rs35686517 chr7:95052611 G/A cg07404485 chr7:94953653 PON1 -0.47 -6.05 -0.32 3.87e-9 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs7618501 0.699 rs2777888 chr3:49898000 A/G cg24308560 chr3:49941425 MST1R -0.49 -7.65 -0.39 2.21e-13 Intelligence (multi-trait analysis); CRC cis rs9682041 1.000 rs6773095 chr3:170082181 A/G cg11886554 chr3:170076028 SKIL 0.84 9.03 0.45 1.5e-17 Glomerular filtration rate in non diabetics (creatinine);Glomerular filtration rate (creatinine); CRC cis rs7208859 0.573 rs7222803 chr17:29119897 A/G cg13385521 chr17:29058706 SUZ12P 0.73 8.3 0.42 2.69e-15 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs6504622 1.000 rs4968285 chr17:45015632 T/C cg16759221 chr17:45003025 GOSR2 0.45 7.09 0.36 8.29e-12 Orofacial clefts; CRC cis rs7493 0.950 rs17166868 chr7:95033416 C/T cg21856205 chr7:94953877 PON1 -0.52 -6.67 -0.35 1.06e-10 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs875971 0.666 rs13242072 chr7:65765988 A/G cg11764359 chr7:65958608 NA -0.54 -8.34 -0.42 1.99e-15 Aortic root size; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg11035813 chr11:71159731 DHCR7 0.42 5.96 0.31 6.34e-9 Response to antipsychotic treatment; CRC cis rs4664293 0.967 rs9646765 chr2:160565648 T/C cg08347373 chr2:160653686 CD302 -0.44 -7.19 -0.37 4.33e-12 Monocyte percentage of white cells; CRC cis rs7829975 0.593 rs2921051 chr8:8320104 C/A cg08975724 chr8:8085496 FLJ10661 0.48 7.43 0.38 9.59e-13 Mood instability; CRC cis rs4664293 0.867 rs6740910 chr2:160649220 G/A cg08347373 chr2:160653686 CD302 -0.51 -7.97 -0.4 2.62e-14 Monocyte percentage of white cells; CRC trans rs9784649 0.760 rs17343923 chr5:25052414 G/A cg11038491 chr20:34638489 LOC647979 -0.67 -8.44 -0.42 1.03e-15 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs7089973 0.624 rs1359080 chr10:116582419 C/A cg23260525 chr10:116636907 FAM160B1 0.34 7.73 0.39 1.3e-13 Bipolar disorder or attention deficit hyperactivity disorder; CRC cis rs7666738 0.830 rs11726604 chr4:99000969 T/C cg05340658 chr4:99064831 C4orf37 0.61 9.54 0.47 3.44e-19 Colonoscopy-negative controls vs population controls; CRC cis rs28386778 0.787 rs2665827 chr17:61961350 G/C cg11494091 chr17:61959527 GH2 0.62 10.12 0.49 3.83e-21 Prudent dietary pattern; CRC cis rs7666738 0.830 rs4443295 chr4:99044935 G/A cg17366294 chr4:99064904 C4orf37 0.44 7.39 0.38 1.25e-12 Colonoscopy-negative controls vs population controls; CRC cis rs7177699 0.557 rs12442476 chr15:79117856 G/A cg15571903 chr15:79123663 NA 0.31 6.21 0.32 1.61e-9 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; CRC cis rs6456156 1.000 rs7761159 chr6:167519907 T/A cg07741184 chr6:167504864 NA 0.37 6.48 0.34 3.38e-10 Primary biliary cholangitis; CRC cis rs7493 0.755 rs34774523 chr7:94962142 G/A cg20119798 chr7:94954144 PON1 -0.44 -5.69 -0.3 2.8e-8 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs4713118 0.513 rs202908 chr6:28011551 C/G cg10876282 chr6:28092338 ZSCAN16 0.48 6.51 0.34 2.81e-10 Parkinson's disease; CRC cis rs7258465 1.000 rs10427083 chr19:18550276 C/A cg06462663 chr19:18546047 ISYNA1 0.5 7.39 0.38 1.26e-12 Breast cancer; CRC cis rs7224685 0.501 rs7211478 chr17:3897178 C/T cg09695851 chr17:3907499 NA 0.84 16.63 0.68 1.62e-45 Type 2 diabetes; CRC cis rs11098499 0.866 rs7677068 chr4:120291704 C/T cg24375607 chr4:120327624 NA 0.48 7.48 0.38 6.72e-13 Corneal astigmatism; CRC cis rs10752881 1.000 rs10797812 chr1:182984597 A/G ch.1.3577855R chr1:183094577 LAMC1 -0.82 -14.63 -0.63 1.1e-37 Colorectal cancer; CRC cis rs7945718 0.621 rs11022465 chr11:12686139 C/T cg25843174 chr11:12811716 TEAD1 -0.39 -7.26 -0.37 2.87e-12 Educational attainment (years of education); CRC cis rs9435341 0.965 rs12401598 chr1:107580533 C/A cg15468180 chr1:107600409 PRMT6 0.43 6.41 0.33 5.13e-10 Facial morphology (factor 21, depth of nasal alae); CRC cis rs904251 0.523 rs1776455 chr6:37482923 A/T cg01843034 chr6:37503916 NA -0.44 -8.28 -0.42 3.2e-15 Cognitive performance; CRC cis rs1267303 0.637 rs1745371 chr1:46985192 C/T cg25110126 chr1:46999211 NA 0.56 8.65 0.43 2.28e-16 Monobrow; CRC cis rs9938149 0.736 rs7501109 chr16:88320862 C/G cg05435882 chr16:88311214 NA 0.45 6.02 0.32 4.61e-9 Corneal structure;Central corneal thickness; CRC cis rs13217239 0.646 rs12523820 chr6:27001502 A/G cg12292205 chr6:26970375 C6orf41 0.56 9.45 0.46 6.32e-19 Schizophrenia; CRC cis rs9311676 0.632 rs12487420 chr3:58399511 A/G cg06643156 chr3:58380774 PXK 0.42 6.38 0.33 5.84e-10 Systemic lupus erythematosus; CRC cis rs56283067 0.847 rs60328783 chr6:44693099 C/G cg18551225 chr6:44695536 NA -0.41 -5.97 -0.31 6.18e-9 Total body bone mineral density; CRC cis rs6088590 0.965 rs6088620 chr20:33412022 A/G cg08999081 chr20:33150536 PIGU 0.51 8.66 0.43 2.15e-16 Coronary artery disease; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg06473843 chr1:32757546 HDAC1 0.42 6.62 0.34 1.49e-10 Liver disease severity in Alagille syndrome; CRC cis rs9398803 0.796 rs1361107 chr6:126767511 A/C cg19875578 chr6:126661172 C6orf173 0.44 6.21 0.32 1.64e-9 Male-pattern baldness; CRC cis rs875971 1.000 rs1981798 chr7:65954903 G/T cg00343986 chr7:65444356 GUSB 0.43 6.2 0.32 1.7e-9 Aortic root size; CRC trans rs2727020 0.595 rs10839281 chr11:49483373 A/C cg11707556 chr5:10655725 ANKRD33B -0.41 -7.67 -0.39 1.95e-13 Coronary artery disease; CRC cis rs453301 0.571 rs2929452 chr8:9084465 G/A cg06636001 chr8:8085503 FLJ10661 -0.56 -8.88 -0.44 4.49e-17 Joint mobility (Beighton score); CRC trans rs10242455 0.571 rs13438288 chr7:98916414 T/G cg09045935 chr12:6379348 NA 0.94 7.24 0.37 3.29e-12 Blood metabolite levels; CRC cis rs875971 0.825 rs10281499 chr7:66048966 A/G cg11764359 chr7:65958608 NA -0.59 -8.75 -0.43 1.12e-16 Aortic root size; CRC cis rs6456156 0.806 rs11967165 chr6:167529936 T/C cg19688584 chr6:167529678 CCR6 -0.35 -6.37 -0.33 6.26e-10 Primary biliary cholangitis; CRC cis rs9322193 0.923 rs9800580 chr6:149953981 C/T cg00933542 chr6:150070202 PCMT1 0.29 6.08 0.32 3.37e-9 Lung cancer; CRC cis rs3093024 0.595 rs4412174 chr6:167476066 A/G cg07741184 chr6:167504864 NA 0.43 7.35 0.38 1.61e-12 Rheumatoid arthritis; CRC trans rs1814175 0.817 rs10769648 chr11:50013992 T/C cg11707556 chr5:10655725 ANKRD33B -0.43 -8.45 -0.42 9.43e-16 Height; CRC cis rs9322193 0.923 rs9800806 chr6:150061486 G/T cg07701084 chr6:150067640 NUP43 0.61 9.04 0.45 1.41e-17 Lung cancer; CRC cis rs8141529 0.673 rs132548 chr22:29317559 C/G cg02153584 chr22:29168773 CCDC117 -0.4 -5.95 -0.31 7.01e-9 Lymphocyte counts; CRC cis rs9462846 0.959 rs9462845 chr6:42860958 A/G cg02353165 chr6:42928485 GNMT 0.54 6.91 0.36 2.57e-11 Blood protein levels; CRC cis rs72634258 0.520 rs4908485 chr1:7907984 A/G cg26816564 chr1:7831052 VAMP3 0.85 9.29 0.46 2.2e-18 Inflammatory bowel disease; CRC trans rs875971 0.545 rs17138156 chr7:65714695 C/T cg02869306 chr7:64672164 INTS4L1 -0.43 -6.21 -0.32 1.63e-9 Aortic root size; CRC cis rs2576037 0.545 rs9948405 chr18:44494527 C/G cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.55 -8.38 -0.42 1.56e-15 Personality dimensions; CRC trans rs2018683 0.624 rs6462119 chr7:29003725 G/C cg19402173 chr7:128379420 CALU -0.51 -7.45 -0.38 8.22e-13 Response to irinotecan and platinum-based chemotherapy in non-small-cell lung cancer; CRC cis rs3106136 0.967 rs2664892 chr4:95154186 T/C cg11021082 chr4:95130006 SMARCAD1 -0.46 -7.26 -0.37 2.84e-12 Capecitabine sensitivity; CRC cis rs28386778 0.863 rs894414 chr17:61916384 T/C cg06873352 chr17:61820015 STRADA 0.76 14.12 0.61 1.01e-35 Prudent dietary pattern; CRC cis rs6496667 0.600 rs62019401 chr15:91071855 C/T cg04176472 chr15:90893244 GABARAPL3 0.49 7.4 0.38 1.18e-12 Rheumatoid arthritis; CRC cis rs394563 0.967 rs369643 chr6:149799798 A/G cg07828024 chr6:149772892 ZC3H12D -0.47 -8.28 -0.42 3.11e-15 Dupuytren's disease; CRC cis rs13108904 0.870 rs1564508 chr4:1244879 A/G cg02018176 chr4:1364513 KIAA1530 0.39 6.58 0.34 1.82e-10 Obesity-related traits; CRC cis rs11711311 1.000 rs10934243 chr3:113430239 T/A cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.52 -7.02 -0.36 1.29e-11 IgG glycosylation; CRC trans rs7027930 0.524 rs11791403 chr9:604686 C/T cg27061366 chr19:13044373 FARSA 0.51 6.36 0.33 6.93e-10 Pulmonary function decline; CRC trans rs1455244 0.700 rs7229302 chr18:11508904 G/T cg24642196 chr1:161136063 PPOX 0.4 6.13 0.32 2.58e-9 Schizophrenia; CRC cis rs11148252 0.574 rs61958118 chr13:53170226 C/T cg00495681 chr13:53174319 NA 0.91 17.51 0.69 5.67e-49 Lewy body disease; CRC cis rs10870270 1.000 rs3935905 chr10:133758262 A/C cg17892150 chr10:133769511 PPP2R2D -0.75 -11.5 -0.54 5.99e-26 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; CRC cis rs600806 0.815 rs3768495 chr1:109935325 C/T cg23032129 chr1:109941072 SORT1 -0.28 -6.06 -0.32 3.68e-9 Intelligence (multi-trait analysis); CRC cis rs7584330 0.554 rs13405619 chr2:238445661 C/T cg14458575 chr2:238380390 NA 0.51 7.09 0.36 8.12e-12 Prostate cancer; CRC cis rs1577917 0.958 rs12203457 chr6:86689277 T/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.51 -6.77 -0.35 5.76e-11 Response to antipsychotic treatment; CRC cis rs7586879 0.639 rs2033654 chr2:25103108 C/A cg22495460 chr2:25135724 ADCY3 -0.84 -16.2 -0.67 8.51e-44 Body mass index; CRC cis rs4975709 0.610 rs4975706 chr5:1860365 G/T cg11168104 chr5:1857477 NA -0.38 -6.59 -0.34 1.79e-10 Cardiovascular disease risk factors; CRC cis rs911186 0.679 rs67330695 chr6:27103654 G/A cg12292205 chr6:26970375 C6orf41 -0.78 -8.5 -0.42 6.72e-16 Autism spectrum disorder or schizophrenia; CRC cis rs7666738 0.830 rs13145011 chr4:98993410 G/A cg05340658 chr4:99064831 C4orf37 0.61 9.54 0.47 3.44e-19 Colonoscopy-negative controls vs population controls; CRC cis rs4253772 0.678 rs1055659 chr22:46638298 C/T cg09491104 chr22:46646882 C22orf40 -0.39 -5.88 -0.31 1.03e-8 LDL cholesterol;Cholesterol, total; CRC cis rs4664308 0.505 rs1037694 chr2:161028992 A/G cg03641300 chr2:160917029 PLA2R1 -0.59 -9.59 -0.47 2.25e-19 Idiopathic membranous nephropathy; CRC cis rs758324 0.812 rs13165154 chr5:131155020 C/T cg25547332 chr5:131281432 NA 0.36 5.69 0.3 2.81e-8 Alzheimer's disease in APOE e4- carriers; CRC cis rs6860806 0.507 rs2631364 chr5:131706914 C/G cg18758796 chr5:131593413 PDLIM4 -0.41 -6.68 -0.35 1.01e-10 Breast cancer; CRC cis rs1712517 0.503 rs72846198 chr10:105098024 G/A cg04362960 chr10:104952993 NT5C2 -0.46 -6.06 -0.32 3.73e-9 Migraine; CRC trans rs587242 1.000 rs7543590 chr1:96892216 T/C cg10631902 chr5:14652156 NA 0.45 6.9 0.36 2.7e-11 Body mass index (joint analysis main effects and physical activity interaction);Body mass index in physically inactive individuals;Body mass index; CRC cis rs10982256 0.905 rs10982255 chr9:117255744 C/T cg13636371 chr9:117264095 DFNB31 0.39 7.46 0.38 7.99e-13 Bipolar disorder; CRC cis rs8180040 0.932 rs11711265 chr3:47558448 T/C cg02527881 chr3:46936655 PTH1R -0.39 -7.4 -0.38 1.17e-12 Colorectal cancer; CRC cis rs7605827 0.930 rs7588148 chr2:15706392 G/A cg19274914 chr2:15703543 NA 0.41 6.14 0.32 2.43e-9 Educational attainment (years of education); CRC cis rs13144136 0.687 rs11723949 chr4:10658093 G/T cg10242279 chr4:10666415 CLNK -0.39 -6.63 -0.34 1.39e-10 Resistance to antihypertensive treatment in hypertension; CRC cis rs4713118 0.621 rs9295756 chr6:28033396 G/T cg12172441 chr6:28176163 NA 0.6 7.38 0.38 1.33e-12 Parkinson's disease; CRC cis rs6951245 1.000 rs74785791 chr7:1088494 T/C cg21664854 chr7:1097933 C7orf50;GPR146 0.79 8.71 0.43 1.52e-16 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs2404602 0.692 rs56193230 chr15:76934472 C/T cg22467129 chr15:76604101 ETFA -0.38 -6.37 -0.33 6.46e-10 Blood metabolite levels; CRC cis rs4319547 0.956 rs10773302 chr12:123043145 G/T cg23029597 chr12:123009494 RSRC2 -0.61 -8.03 -0.4 1.73e-14 Body mass index; CRC cis rs860295 0.665 rs11264393 chr1:155574471 C/A cg02153340 chr1:155202674 NA -0.51 -6.43 -0.33 4.4e-10 Body mass index; CRC cis rs2251381 0.778 rs2471947 chr21:30534219 G/T cg08807101 chr21:30365312 RNF160 0.64 9.58 0.47 2.38e-19 Selective IgA deficiency; CRC cis rs763121 0.925 rs9611008 chr22:39098787 T/C cg06022373 chr22:39101656 GTPBP1 0.74 12.26 0.56 1.03e-28 Menopause (age at onset); CRC cis rs4731207 0.698 rs6466955 chr7:124518766 T/C cg23710748 chr7:124431027 NA -0.38 -6.14 -0.32 2.36e-9 Cutaneous malignant melanoma; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg13980007 chr1:61547494 NFIA 0.44 6.59 0.34 1.76e-10 Liver disease severity in Alagille syndrome; CRC cis rs73206853 0.563 rs16940992 chr12:111207515 C/T cg12870014 chr12:110450643 ANKRD13A -0.76 -10.7 -0.51 4.01e-23 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC cis rs950169 0.580 rs17532346 chr15:85171495 A/C cg17507749 chr15:85114479 UBE2QP1 0.63 9.01 0.44 1.71e-17 Schizophrenia; CRC cis rs9303542 0.559 rs12947405 chr17:46614755 C/T cg04904318 chr17:46607828 HOXB1 -0.53 -6.2 -0.32 1.68e-9 Ovarian cancer;Epithelial ovarian cancer; CRC trans rs2727020 0.681 rs1976901 chr11:49378697 T/C cg03929089 chr4:120376271 NA -0.83 -14.64 -0.63 1.03e-37 Coronary artery disease; CRC cis rs2032447 0.832 rs6922788 chr6:26052291 C/T cg03517284 chr6:25882590 NA -0.48 -6.62 -0.34 1.49e-10 Intelligence (multi-trait analysis); CRC cis rs10876993 0.890 rs1689597 chr12:58051886 G/A cg15848620 chr12:58087721 OS9 -0.65 -8.91 -0.44 3.64e-17 Celiac disease or Rheumatoid arthritis; CRC trans rs875971 0.660 rs2191268 chr7:66110224 C/T cg00699235 chr12:49962218 MCRS1 -0.39 -5.96 -0.31 6.44e-9 Aortic root size; CRC cis rs8017423 0.647 rs12882973 chr14:90820502 G/A cg14092571 chr14:90743983 NA 0.39 5.98 0.31 5.81e-9 Mortality in heart failure; CRC cis rs12477438 0.798 rs4324365 chr2:99623845 T/G cg26064155 chr2:99771622 LIPT1;TSGA10 -0.79 -11.26 -0.53 4.29e-25 Chronic sinus infection; CRC cis rs736408 0.522 rs998909 chr3:52805093 A/G cg18404041 chr3:52824283 ITIH1 -0.4 -8.23 -0.41 4.34e-15 Bipolar disorder; CRC cis rs887829 0.588 rs6715325 chr2:234635241 A/G cg02227331 chr2:234663937 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 0.41 6.7 0.35 9.3e-11 Metabolic traits;Bilirubin levels;Cholelithiasis-related traits in sickle cell anemia;Metabolite levels;Total bilirubin levels in HIV-1 infection;Serum metabolite levels;Blood metabolite levels; CRC cis rs4862750 0.872 rs11947595 chr4:187899827 C/T cg11301795 chr4:187892539 NA -0.87 -20.32 -0.75 4.87e-60 Lobe attachment (rater-scored or self-reported); CRC cis rs6570726 0.935 rs377130 chr6:145836632 C/T cg23711669 chr6:146136114 FBXO30 0.68 12.16 0.56 2.33e-28 Lobe attachment (rater-scored or self-reported); CRC cis rs10883723 0.810 rs10883729 chr10:104273943 A/G cg22532475 chr10:104410764 TRIM8 -0.36 -6.63 -0.34 1.36e-10 Allergic disease (asthma, hay fever or eczema); CRC cis rs4713118 0.662 rs9468277 chr6:28028390 C/A cg02683197 chr6:28174875 NA 0.75 9.78 0.47 5.25e-20 Parkinson's disease; CRC cis rs7618915 0.547 rs62255362 chr3:52699741 C/G cg08222913 chr3:52553049 STAB1 -0.34 -6.23 -0.32 1.45e-9 Bipolar disorder; CRC cis rs10504229 0.609 rs66477547 chr8:58105763 A/C cg24829409 chr8:58192753 C8orf71 -0.55 -7.79 -0.39 8.58e-14 Developmental language disorder (linguistic errors); CRC cis rs4901869 0.966 rs9972206 chr14:59336095 A/G cg02291164 chr14:59296302 NA 0.34 6.26 0.33 1.22e-9 Panic disorder; CRC cis rs4481887 0.927 rs10888344 chr1:248446655 T/C cg00666640 chr1:248458726 OR2T12 0.53 9.62 0.47 1.75e-19 Common traits (Other); CRC cis rs3760982 0.585 rs67704568 chr19:44294019 T/C cg11993925 chr19:44307056 LYPD5 0.56 10.05 0.48 6.72e-21 Breast cancer (estrogen-receptor negative);Breast cancer; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg23312964 chr11:47430184 SLC39A13 0.46 6.34 0.33 7.68e-10 Anxiety disorder; CRC cis rs911555 0.755 rs11620897 chr14:103944861 T/G cg24130564 chr14:104152367 KLC1 -0.42 -5.88 -0.31 1e-8 Intelligence (multi-trait analysis); CRC cis rs375066 0.592 rs349046 chr19:44300626 C/T cg11993925 chr19:44307056 LYPD5 -0.38 -6.2 -0.32 1.64e-9 Breast cancer; CRC cis rs7727544 0.904 rs6897575 chr5:131604535 C/T cg04518342 chr5:131593106 PDLIM4 0.36 6.73 0.35 7.48e-11 Blood metabolite levels; CRC cis rs782590 0.902 rs3762513 chr2:55762957 C/T cg18811423 chr2:55921094 PNPT1 0.84 15.62 0.65 1.53e-41 Metabolic syndrome; CRC cis rs7726839 0.540 rs4957081 chr5:646418 G/C cg14541582 chr5:601475 NA -0.33 -6.59 -0.34 1.73e-10 Obesity-related traits; CRC cis rs4638749 1.000 rs12477202 chr2:108867112 G/A cg25838818 chr2:108905173 SULT1C2 -0.39 -6.21 -0.32 1.58e-9 Blood pressure; CRC trans rs4263408 0.934 rs9683743 chr4:39703194 A/C cg11951909 chr7:158497997 NCAPG2 -0.48 -7.31 -0.37 2.04e-12 Plasma amyloid beta peptide concentrations (ABx-40); CRC cis rs3824347 0.839 rs4745372 chr9:77584225 G/A cg01251476 chr9:77566080 C9orf40 0.37 5.7 0.3 2.63e-8 Urinary magnesium-to-creatinine ratio; CRC cis rs2404602 1.000 rs1117367 chr15:76872330 A/C cg23625390 chr15:77176239 SCAPER 0.57 8.71 0.43 1.46e-16 Blood metabolite levels; CRC cis rs637571 0.510 rs10750772 chr11:65577427 C/T cg26695010 chr11:65641043 EFEMP2 0.48 7.47 0.38 7.46e-13 Eosinophil percentage of white cells; CRC cis rs972578 0.806 rs8137128 chr22:43385996 A/T cg01576275 chr22:43409880 NA -0.48 -7.68 -0.39 1.87e-13 Mean platelet volume; CRC cis rs8103278 0.793 rs59093775 chr19:46374037 G/A cg14061069 chr19:46274453 DMPK -0.44 -6.13 -0.32 2.45e-9 Coronary artery disease; CRC cis rs713477 0.678 rs4901566 chr14:55912663 C/A cg21836586 chr14:55907198 TBPL2 0.31 5.73 0.3 2.26e-8 Pediatric bone mineral content (femoral neck); CRC cis rs898097 0.812 rs8065641 chr17:80820259 A/G cg15369054 chr17:80825471 TBCD 0.53 8.88 0.44 4.27e-17 Breast cancer; CRC cis rs1129187 0.967 rs11752813 chr6:42928017 C/G cg03790207 chr6:42947109 PEX6 -0.44 -6.17 -0.32 2.02e-9 Alzheimer's disease in APOE e4+ carriers; CRC cis rs548181 0.736 rs556884 chr11:125550049 G/A cg03464685 chr11:125439445 EI24 1.26 12.94 0.58 3.06e-31 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs7845219 0.544 rs2945554 chr8:95939594 C/A cg16049864 chr8:95962084 TP53INP1 -0.43 -6.42 -0.33 4.62e-10 Type 2 diabetes; CRC cis rs2404602 0.647 rs907594 chr15:77197745 C/A cg03037974 chr15:76606532 NA -0.54 -7.97 -0.4 2.68e-14 Blood metabolite levels; CRC cis rs7827545 1.000 rs4909910 chr8:135565201 T/C cg17885191 chr8:135476712 NA 0.55 7.57 0.38 3.91e-13 Hypertension (SNP x SNP interaction); CRC cis rs1801251 1.000 rs7558609 chr2:233700379 C/T cg25237894 chr2:233734115 C2orf82 0.54 8.82 0.44 6.85e-17 Coronary artery disease; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg15045943 chr5:171614719 STK10 0.59 7.96 0.4 2.77e-14 Thyroid stimulating hormone; CRC cis rs4731207 0.671 rs10085867 chr7:124486168 T/C cg23710748 chr7:124431027 NA 0.38 6.08 0.32 3.42e-9 Cutaneous malignant melanoma; CRC cis rs4689592 0.546 rs2359012 chr4:7066053 A/C cg06697600 chr4:7070879 GRPEL1 -0.5 -7.39 -0.38 1.19e-12 Monocyte percentage of white cells; CRC cis rs62229266 0.804 rs62230822 chr21:37429945 T/C cg08632701 chr21:37451849 NA -0.43 -6.74 -0.35 7e-11 Mitral valve prolapse; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg24076778 chr1:151512662 TUFT1 0.44 6.44 0.33 4.25e-10 Intelligence (multi-trait analysis); CRC cis rs68170813 0.559 rs11761181 chr7:106954879 T/C cg02696742 chr7:106810147 HBP1 -0.6 -6.56 -0.34 2.06e-10 Coronary artery disease; CRC cis rs6968419 0.755 rs10500059 chr7:115900394 C/T cg02561103 chr7:115862891 TES -0.44 -6.55 -0.34 2.21e-10 Intraocular pressure; CRC cis rs4713118 0.955 rs9468200 chr6:27683063 T/A cg12172441 chr6:28176163 NA 0.49 6.29 0.33 9.97e-10 Parkinson's disease; CRC cis rs3026101 0.624 rs1058398 chr17:5288760 C/T cg25236894 chr17:5323110 RPAIN;NUP88 -0.4 -6.69 -0.35 9.63e-11 Body mass index; CRC cis rs561341 0.882 rs16967101 chr17:30377162 A/G cg23018236 chr17:30244563 NA -0.49 -6.51 -0.34 2.73e-10 Hip circumference adjusted for BMI; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg16921014 chr4:146403948 SMAD1 0.39 5.99 0.31 5.37e-9 Liver disease severity in Alagille syndrome; CRC cis rs2976388 0.506 rs2572902 chr8:143791387 A/G cg12516270 chr8:143859308 LYNX1 0.44 7.79 0.39 8.89e-14 Urinary tract infection frequency; CRC trans rs1455244 0.700 rs7229302 chr18:11508904 G/T cg10598356 chr15:63797185 USP3 0.47 7.33 0.37 1.81e-12 Schizophrenia; CRC cis rs6496667 0.779 rs7181256 chr15:90966518 T/C cg04176472 chr15:90893244 GABARAPL3 0.58 8.17 0.41 6.49e-15 Rheumatoid arthritis; CRC trans rs7618501 0.633 rs4688689 chr3:50035542 C/T cg21665057 chr3:196295764 WDR53;FBXO45 0.62 9.58 0.47 2.44e-19 Intelligence (multi-trait analysis); CRC cis rs9926296 0.585 rs8058009 chr16:89856439 G/C cg07402062 chr16:89894098 SPIRE2 -0.44 -5.79 -0.3 1.63e-8 Vitiligo; CRC cis rs898097 0.544 rs6502022 chr17:80908652 C/T cg15369054 chr17:80825471 TBCD -0.35 -5.86 -0.31 1.13e-8 Breast cancer; CRC trans rs116095464 0.510 rs55750776 chr5:230467 T/C cg00938859 chr5:1591904 SDHAP3 0.72 7.96 0.4 2.76e-14 Breast cancer; CRC cis rs35365539 1 rs35365539 chr3:49794347 A/AC cg24308560 chr3:49941425 MST1R 0.46 7.23 0.37 3.51e-12 Blood protein levels; CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg26529371 chr19:12911983 PRDX2 0.34 6.29 0.33 9.9e-10 Obesity-related traits; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg17708571 chr19:2151588 AP3D1 0.37 6.38 0.33 6.07e-10 Liver disease severity in Alagille syndrome; CRC cis rs6951245 1.000 rs11763793 chr7:1094342 A/G cg26224354 chr7:1096374 C7orf50;GPR146 -0.94 -12.2 -0.56 1.7e-28 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs951366 0.789 rs823152 chr1:205736285 G/A cg14893161 chr1:205819251 PM20D1 0.86 13.81 0.61 1.51e-34 Menarche (age at onset); CRC cis rs7998202 0.720 rs914020 chr13:113352848 C/G cg02820901 chr13:113351484 ATP11A 0.65 7.49 0.38 6.49e-13 Glycated hemoglobin levels; CRC cis rs13191362 1.000 rs35820211 chr6:163046252 C/T cg06582575 chr6:163149167 PACRG;PARK2 0.91 11.12 0.52 1.33e-24 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs9611565 0.512 rs5751145 chr22:42133552 C/T cg03806693 chr22:41940476 POLR3H 1.07 12.89 0.58 4.71e-31 Vitiligo; CRC cis rs7412746 0.658 rs17660092 chr1:150797748 T/C cg10589385 chr1:150898437 SETDB1 0.3 6.31 0.33 9.09e-10 Melanoma; CRC cis rs1816752 1.000 rs9511265 chr13:25012359 T/C cg02811702 chr13:24901961 NA 0.48 6.54 0.34 2.39e-10 Obesity-related traits; CRC cis rs7811142 1.000 rs113738841 chr7:100081306 C/T cg00814883 chr7:100076585 TSC22D4 -0.74 -9.4 -0.46 9.54e-19 Platelet count; CRC cis rs875971 0.756 rs2901210 chr7:66017505 G/A cg00343986 chr7:65444356 GUSB -0.43 -5.97 -0.31 6.04e-9 Aortic root size; CRC cis rs7258465 1.000 rs34256197 chr19:18606472 G/A cg10790698 chr19:18539756 SSBP4 -0.45 -8.6 -0.43 3.27e-16 Breast cancer; CRC trans rs1814175 0.817 rs3974439 chr11:50022607 G/A cg03929089 chr4:120376271 NA -0.95 -19.14 -0.73 2.04e-55 Height; CRC cis rs10870270 1.000 rs11146354 chr10:133774757 A/G cg08754478 chr10:133766260 PPP2R2D -0.65 -8.99 -0.44 2.05e-17 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; CRC cis rs9584850 0.834 rs745638 chr13:99119307 C/G cg20487152 chr13:99095054 FARP1 -0.41 -6.11 -0.32 2.8e-9 Neuroticism; CRC cis rs10450586 0.863 rs10437622 chr11:27307178 C/T cg10370305 chr11:27303972 NA 0.37 6.02 0.31 4.69e-9 Total body bone mineral density; CRC cis rs3812049 0.784 rs7734927 chr5:127453735 T/A cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.65 8.22 0.41 4.63e-15 Lymphocyte counts;Red cell distribution width; CRC cis rs6120849 0.754 rs6119560 chr20:33606977 G/C cg24642439 chr20:33292090 TP53INP2 0.43 5.61 0.3 4.28e-8 Protein C levels; CRC cis rs9467711 0.560 rs6900665 chr6:26487169 C/T cg16898833 chr6:26189333 HIST1H4D 0.85 7.2 0.37 4.07e-12 Autism spectrum disorder or schizophrenia; CRC cis rs8018808 0.935 rs17824034 chr14:77878683 A/G cg20045696 chr14:77926864 AHSA1 0.38 5.87 0.31 1.08e-8 Myeloid white cell count; CRC cis rs9916302 0.904 rs11867312 chr17:37597748 C/T cg03013999 chr17:37608204 MED1 0.47 7.28 0.37 2.48e-12 Glomerular filtration rate (creatinine); CRC cis rs9660992 1.000 rs1779410 chr1:205248759 A/G cg21643547 chr1:205240462 TMCC2 -0.42 -7.06 -0.36 9.72e-12 Mean corpuscular volume;Mean platelet volume; CRC cis rs7843479 0.544 rs4872110 chr8:21784989 A/G cg16476235 chr8:21771668 DOK2 0.37 5.99 0.31 5.55e-9 Mean corpuscular volume; CRC cis rs2274471 0.645 rs3780375 chr9:5109431 G/A cg03390472 chr9:5043263 JAK2 -0.55 -6.29 -0.33 9.87e-10 Crohn's disease; CRC cis rs6460942 0.778 rs17444259 chr7:12462428 C/T cg06484146 chr7:12443880 VWDE -0.69 -8.52 -0.42 5.98e-16 Coronary artery disease; CRC trans rs2228479 0.702 rs11649501 chr16:89850957 A/T cg24644049 chr4:85504048 CDS1 0.92 7.64 0.39 2.42e-13 Skin colour saturation; CRC cis rs2302190 0.882 rs7209650 chr17:56674905 C/T cg25885038 chr17:56607967 SEPT4 -0.5 -7.59 -0.39 3.27e-13 Vitamin D levels; CRC cis rs3096299 0.685 rs4785675 chr16:89539974 T/C cg00750074 chr16:89608354 SPG7 -0.49 -7.57 -0.39 3.74e-13 Multiple myeloma (IgH translocation); CRC cis rs7208859 0.673 rs12103759 chr17:29235687 G/A cg13385521 chr17:29058706 SUZ12P 0.69 7.99 0.4 2.27e-14 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs12024301 0.557 rs12037290 chr1:183637038 C/T cg11505048 chr1:183622726 RGL1;APOBEC4 0.81 7.0 0.36 1.42e-11 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs2036402 1.000 rs7719994 chr5:156430076 T/C cg21915449 chr5:156456672 HAVCR1 -0.46 -5.62 -0.3 3.99e-8 Hypertriglyceridemia; CRC trans rs459571 1.000 rs2810489 chr9:136922700 C/T cg15028160 chr19:49622717 PPFIA3;C19orf73 -0.56 -7.06 -0.36 1.02e-11 Platelet distribution width; CRC cis rs7615952 0.599 rs6438953 chr3:125724951 T/C cg04553112 chr3:125709451 NA -0.48 -6.14 -0.32 2.33e-9 Blood pressure (smoking interaction); CRC cis rs2732480 0.557 rs2732484 chr12:48737245 A/C cg04545296 chr12:48745243 ZNF641 0.36 6.19 0.32 1.81e-9 Hemoglobin concentration;Red blood cell count;Hematocrit; CRC cis rs9443189 0.570 rs529383 chr6:76297847 T/G cg01950844 chr6:76311363 SENP6 0.7 8.21 0.41 5.13e-15 Prostate cancer; CRC cis rs644799 0.862 rs1150361 chr11:95633805 G/A cg25478527 chr11:95522999 CEP57;FAM76B 0.5 7.39 0.38 1.23e-12 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs367943 1.000 rs348929 chr5:112814883 T/A cg12552261 chr5:112820674 MCC -0.49 -7.66 -0.39 2.06e-13 Type 2 diabetes; CRC cis rs11098499 0.754 rs10213554 chr4:120260785 A/G cg24375607 chr4:120327624 NA -0.5 -7.96 -0.4 2.85e-14 Corneal astigmatism; CRC cis rs12580194 0.593 rs61957936 chr12:55745719 A/G cg19537932 chr12:55886519 OR6C68 -0.66 -8.56 -0.43 4.26e-16 Cancer; CRC cis rs1552244 0.515 rs111560858 chr3:10166845 G/A cg13047869 chr3:10149882 C3orf24 0.53 6.46 0.34 3.76e-10 Alzheimer's disease; CRC cis rs3617 0.573 rs13072537 chr3:52896032 C/A cg11645453 chr3:52864694 ITIH4 0.35 6.36 0.33 6.75e-10 Red blood cell count;Autism spectrum disorder or schizophrenia; CRC cis rs1707322 0.721 rs6429575 chr1:46134216 G/C cg03146154 chr1:46216737 IPP 0.67 9.75 0.47 6.98e-20 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC trans rs951252 0.504 rs11734405 chr4:146081096 C/T cg19105961 chr17:4046223 CYB5D2;ZZEF1 0.48 6.52 0.34 2.68e-10 Hip circumference; CRC trans rs6678914 1.000 rs6678914 chr1:202187176 G/A cg19977628 chr5:1262072 TERT 0.4 6.0 0.31 5.23e-9 Breast cancer (estrogen-receptor negative);Breast cancer; CRC cis rs9926296 0.681 rs12923946 chr16:89821080 C/T cg04287289 chr16:89883240 FANCA 0.54 8.28 0.42 3.04e-15 Vitiligo; CRC cis rs995000 0.868 rs1168017 chr1:63002551 A/G cg19896129 chr1:63156450 NA -0.45 -7.04 -0.36 1.15e-11 Triglyceride levels; CRC cis rs13082711 0.539 rs383135 chr3:27555866 A/G cg02860705 chr3:27208620 NA -0.41 -6.08 -0.32 3.34e-9 Systolic blood pressure;Diastolic blood pressure;Blood pressure; CRC cis rs548181 0.668 rs579661 chr11:125474766 A/G cg03464685 chr11:125439445 EI24 1.19 12.5 0.57 1.37e-29 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs1218582 0.774 rs12036859 chr1:154859940 A/C cg24250549 chr1:154909240 PMVK -0.58 -9.16 -0.45 5.68e-18 Prostate cancer; CRC trans rs4589502 0.800 rs2035150 chr15:67201794 A/C cg10006042 chr16:23042421 NA 0.4 6.21 0.32 1.55e-9 Lung cancer (smoking interaction); CRC cis rs760762 0.506 rs6129731 chr20:39660687 A/C cg11668512 chr20:39929580 ZHX3 0.37 5.65 0.3 3.47e-8 Age-related diseases, mortality and associated endophenotypes;Age-related disease endophenotypes; CRC cis rs2952156 0.920 rs14050 chr17:37828072 C/T cg00129232 chr17:37814104 STARD3 -0.67 -11.13 -0.52 1.21e-24 Asthma; CRC cis rs7474896 0.583 rs1208770 chr10:38044683 C/T cg25427524 chr10:38739819 LOC399744 -0.64 -7.79 -0.39 9.06e-14 Obesity (extreme); CRC cis rs4727027 0.866 rs1405124 chr7:148779618 C/T cg12479418 chr7:148823350 ZNF425;ZNF398 0.44 6.06 0.32 3.76e-9 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC cis rs9926296 0.533 rs12102297 chr16:89812762 C/A cg27121462 chr16:89883253 FANCA 0.56 8.66 0.43 2.17e-16 Vitiligo; CRC cis rs7932354 0.583 rs10838629 chr11:46906845 G/A cg19486271 chr11:47235900 DDB2 -0.43 -6.42 -0.33 4.75e-10 Bone mineral density (hip);Bone mineral density; CRC cis rs11758351 1.000 rs77957229 chr6:26185226 A/G cg08260959 chr6:26240920 HIST1H4F -0.39 -5.97 -0.31 6.1e-9 Gout;Renal underexcretion gout; CRC cis rs9372498 0.505 rs56406560 chr6:118991787 G/A cg01339444 chr6:118972232 C6orf204 0.51 6.09 0.32 3.24e-9 Diastolic blood pressure; CRC cis rs8180040 0.966 rs11130129 chr3:47489885 G/C cg02527881 chr3:46936655 PTH1R 0.39 7.18 0.37 4.82e-12 Colorectal cancer; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg26027482 chr12:1100598 ERC1 0.5 6.46 0.34 3.71e-10 Thyroid stimulating hormone; CRC cis rs4700695 0.841 rs152996 chr5:65256506 A/G cg21114390 chr5:65439923 SFRS12 0.57 6.88 0.35 3.05e-11 Facial morphology (factor 19); CRC cis rs9916302 0.800 rs9892675 chr17:37549200 C/T cg00129232 chr17:37814104 STARD3 0.54 7.28 0.37 2.54e-12 Glomerular filtration rate (creatinine); CRC cis rs11690935 0.959 rs11904009 chr2:172627343 T/G cg13550731 chr2:172543902 DYNC1I2 -1.06 -17.46 -0.69 9.32e-49 Schizophrenia; CRC cis rs6896969 0.510 rs6880419 chr5:40428913 C/T cg09067459 chr5:40385259 NA 0.45 7.75 0.39 1.19e-13 Multiple sclerosis; CRC cis rs9916302 0.706 rs903507 chr17:37726423 A/G cg00129232 chr17:37814104 STARD3 -0.59 -7.21 -0.37 3.76e-12 Glomerular filtration rate (creatinine); CRC cis rs8180040 0.932 rs1038394 chr3:47464122 A/G cg02527881 chr3:46936655 PTH1R -0.39 -7.48 -0.38 6.89e-13 Colorectal cancer; CRC cis rs10504229 0.775 rs17805110 chr8:58161439 C/G cg02290350 chr8:58132656 NA 0.51 6.42 0.33 4.74e-10 Developmental language disorder (linguistic errors); CRC cis rs202629 1 rs202629 chr22:41849975 C/T cg03806693 chr22:41940476 POLR3H 0.95 12.76 0.58 1.43e-30 Cannabis dependence symptom count; CRC cis rs10504229 1.000 rs60651159 chr8:58174074 T/C cg01721255 chr8:58191610 C8orf71 0.49 6.17 0.32 2e-9 Developmental language disorder (linguistic errors); CRC cis rs7527798 0.592 rs7539772 chr1:207833301 G/A cg09232269 chr1:207846808 CR1L -0.51 -8.12 -0.41 9.14e-15 Erythrocyte sedimentation rate; CRC cis rs7258465 1.000 rs4808804 chr19:18585325 A/G cg06462663 chr19:18546047 ISYNA1 0.48 7.32 0.37 1.88e-12 Breast cancer; CRC cis rs881375 1.000 rs10760121 chr9:123647915 G/T cg09586646 chr9:123605570 PSMD5;LOC253039 0.54 7.28 0.37 2.48e-12 Rheumatoid arthritis; CRC trans rs617791 0.530 rs10791835 chr11:65750924 C/A cg17712092 chr4:129076599 LARP1B -0.47 -6.87 -0.35 3.31e-11 Breast cancer; CRC trans rs951252 0.504 rs11734405 chr4:146081096 C/T cg05643349 chr16:30935108 FBXL19;NCRNA00095 0.56 7.48 0.38 6.78e-13 Hip circumference; CRC cis rs143111788 1 rs143111788 chr6:41919175 CCAGCTACT/C cg17623882 chr6:41773611 USP49 -0.52 -8.35 -0.42 1.92e-15 Red cell distribution width; CRC cis rs524023 0.958 rs11231825 chr11:64360274 T/C cg14139581 chr11:64358342 SLC22A12 -0.39 -6.2 -0.32 1.73e-9 Urate levels in obese individuals; CRC cis rs6089584 0.893 rs6089306 chr20:60574868 G/A cg18761221 chr20:60518478 NA 0.41 7.38 0.38 1.34e-12 Body mass index; CRC cis rs4555082 0.718 rs75139030 chr14:105710853 A/AG cg18132624 chr14:105716052 BTBD6;BRF1 -0.51 -8.19 -0.41 5.7e-15 Mean platelet volume;Platelet distribution width; CRC cis rs7833790 0.724 rs4739627 chr8:82734657 A/G cg17211192 chr8:82754475 SNX16 -0.47 -6.61 -0.34 1.59e-10 Diastolic blood pressure; CRC cis rs28386778 0.897 rs8077013 chr17:61850392 C/T cg25654072 chr17:61904446 PSMC5;FTSJ3 0.73 11.3 0.53 2.96e-25 Prudent dietary pattern; CRC cis rs6681460 0.899 rs502690 chr1:67182403 A/T cg02459107 chr1:67143332 SGIP1 0.38 6.77 0.35 6.1e-11 Presence of antiphospholipid antibodies; CRC cis rs2243480 1.000 rs313802 chr7:65516373 A/G cg18252515 chr7:66147081 NA -1.19 -13.16 -0.59 4.5e-32 Diabetic kidney disease; CRC cis rs7508679 0.692 rs10413734 chr19:7227871 T/G cg09779027 chr19:7224513 INSR -0.94 -15.49 -0.65 5.16e-41 Hypothyroidism; CRC cis rs861020 1.000 rs12134698 chr1:209987801 C/A cg05527609 chr1:210001259 C1orf107 -0.99 -12.28 -0.56 8.94e-29 Orofacial clefts; CRC cis rs2204008 0.747 rs11514040 chr12:38201040 G/A cg26384229 chr12:38710491 ALG10B 0.67 9.0 0.44 1.87e-17 Bladder cancer; CRC cis rs7586879 0.828 rs13012304 chr2:25122246 C/T cg22495460 chr2:25135724 ADCY3 -0.87 -14.86 -0.63 1.4e-38 Body mass index; CRC cis rs2811415 0.597 rs9813824 chr3:127761959 C/T cg13719885 chr3:127795394 NA -0.39 -5.99 -0.31 5.56e-9 Lung function (FEV1/FVC); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg16010707 chr12:83081048 TMTC2 0.41 6.19 0.32 1.8e-9 Intelligence (multi-trait analysis); CRC cis rs909674 0.818 rs5750833 chr22:39843091 C/A cg24399712 chr22:39784796 NA -0.43 -8.62 -0.43 2.84e-16 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; CRC cis rs4563143 0.663 rs5025682 chr19:29238670 A/C cg12756686 chr19:29218302 NA 0.65 10.06 0.49 6.07e-21 Methadone dose in opioid dependence; CRC cis rs875971 1.000 rs1544549 chr7:66090663 T/A cg18912574 chr7:65842487 NCRNA00174 -0.37 -6.12 -0.32 2.6e-9 Aortic root size; CRC cis rs11122272 0.735 rs10489610 chr1:231517765 C/A cg06096015 chr1:231504339 EGLN1 0.4 5.94 0.31 7.17e-9 Hemoglobin concentration; CRC cis rs4713675 0.524 rs4713672 chr6:33705066 G/A cg14003231 chr6:33640908 ITPR3 0.44 7.24 0.37 3.12e-12 Plateletcrit; CRC cis rs9326248 0.520 rs74830 chr11:117090558 C/T cg01368799 chr11:117014884 PAFAH1B2 -0.56 -9.08 -0.45 1.02e-17 Blood protein levels; CRC cis rs6951245 1.000 rs74366004 chr7:1088630 A/C cg04025307 chr7:1156635 C7orf50 0.64 6.66 0.34 1.16e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs6500395 0.962 rs2101372 chr16:48627306 G/A cg04672837 chr16:48644449 N4BP1 0.42 6.04 0.32 4.1e-9 Response to tocilizumab in rheumatoid arthritis; CRC cis rs6502050 0.799 rs8066370 chr17:80102105 T/C cg19223190 chr17:80058835 NA 0.4 6.36 0.33 6.88e-10 Life satisfaction; CRC cis rs4730268 0.768 rs79139176 chr7:107438298 C/G cg18560240 chr7:107437656 SLC26A3 -0.55 -5.7 -0.3 2.69e-8 IgG glycosylation; CRC cis rs10463316 0.894 rs7723016 chr5:150764828 T/C cg03212797 chr5:150827313 SLC36A1 -0.5 -7.78 -0.39 9.23e-14 Metabolite levels (Pyroglutamine); CRC cis rs9925964 0.869 rs2288004 chr16:31054040 G/C cg03418659 chr16:31128414 MYST1 0.47 6.84 0.35 3.8e-11 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs6938 0.534 rs12907898 chr15:75207872 C/T cg17294928 chr15:75287854 SCAMP5 0.57 8.72 0.43 1.42e-16 Breast cancer; CRC cis rs60871478 1.000 rs9195 chr7:825786 C/T cg05535760 chr7:792225 HEATR2 -0.83 -11.71 -0.54 1.07e-26 Cerebrospinal P-tau181p levels; CRC cis rs9443645 0.527 rs4706743 chr6:79615793 G/T cg05283184 chr6:79620031 NA -0.44 -6.39 -0.33 5.68e-10 Intelligence (multi-trait analysis); CRC cis rs9894429 0.646 rs7210026 chr17:79612382 T/C cg18240062 chr17:79603768 NPLOC4 0.47 7.42 0.38 1.02e-12 Eye color traits; CRC trans rs2303319 0.504 rs58622044 chr2:162596287 A/G cg22677401 chr17:46026860 NA -0.68 -6.15 -0.32 2.24e-9 Cognitive function; CRC cis rs2032447 0.966 rs3752416 chr6:26045929 T/C cg18357526 chr6:26021779 HIST1H4A 0.75 11.77 0.54 6.44e-27 Intelligence (multi-trait analysis); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg16197653 chr6:170101828 WDR27;C6orf120 0.42 6.44 0.33 4.34e-10 Intelligence (multi-trait analysis); CRC cis rs17539620 0.624 rs62432736 chr6:154834401 A/G cg20019720 chr6:154832845 CNKSR3 0.5 8.28 0.42 3.07e-15 Lipoprotein (a) levels; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg15674719 chr19:1407747 DAZAP1 0.4 6.42 0.33 4.83e-10 Liver disease severity in Alagille syndrome; CRC cis rs709400 1.000 rs56660916 chr14:104126137 G/T cg12935359 chr14:103987150 CKB -0.37 -6.19 -0.32 1.83e-9 Body mass index; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg05776488 chr1:231113872 TTC13;ARV1 0.47 6.5 0.34 2.94e-10 Response to antipsychotic treatment; CRC cis rs2908197 0.806 rs6465098 chr7:75972947 T/C cg10167463 chr7:75959203 YWHAG -0.41 -6.07 -0.32 3.45e-9 3-hydroxypropylmercapturic acid levels in smokers; CRC cis rs1348850 0.651 rs4893931 chr2:178228212 T/C cg02961200 chr2:178257176 LOC100130691;AGPS 0.44 6.22 0.32 1.52e-9 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs694739 0.654 rs10897488 chr11:64140806 T/C cg23796481 chr11:64053134 BAD;GPR137 0.48 6.68 0.35 1e-10 Alopecia areata;Crohn's disease;Psoriasis vulgaris; CRC cis rs1218582 0.774 rs11264284 chr1:154875793 C/T cg06221963 chr1:154839813 KCNN3 -0.8 -16.02 -0.66 4.21e-43 Prostate cancer; CRC cis rs2243480 1.000 rs2177703 chr7:65391717 C/A cg12463550 chr7:65579703 CRCP 0.63 6.04 0.32 4.17e-9 Diabetic kidney disease; CRC cis rs243505 0.737 rs243538 chr7:148404379 G/A cg09806900 chr7:148480153 CUL1 -0.5 -6.25 -0.33 1.24e-9 Inflammatory bowel disease;Crohn's disease; CRC cis rs9527 0.637 rs7096169 chr10:104618695 A/G cg04362960 chr10:104952993 NT5C2 0.59 8.18 0.41 6.25e-15 Arsenic metabolism; CRC cis rs6951245 1.000 rs111899361 chr7:1112348 C/T cg03188948 chr7:1209495 NA 0.65 6.85 0.35 3.56e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs947211 0.846 rs823155 chr1:205762946 T/C cg11965913 chr1:205819406 PM20D1 0.47 7.02 0.36 1.28e-11 Parkinson's disease; CRC trans rs12699921 0.598 rs2691607 chr7:17879103 G/A cg02066331 chr6:17282778 RBM24 -0.35 -6.08 -0.32 3.38e-9 Fibrinogen levels; CRC cis rs1976403 0.659 rs10799701 chr1:21820990 A/G cg20417195 chr1:21767127 NBPF3 0.46 6.93 0.36 2.25e-11 Liver enzyme levels (alkaline phosphatase); CRC cis rs7737355 0.812 rs548635 chr5:131055546 G/T cg25547332 chr5:131281432 NA -0.38 -6.05 -0.32 3.88e-9 Life satisfaction; CRC cis rs2576037 0.583 rs2156049 chr18:44455717 G/A cg23996704 chr18:44553084 KATNAL2 -0.34 -7.02 -0.36 1.25e-11 Personality dimensions; CRC cis rs6912958 0.559 rs445434 chr6:88041849 A/G cg08069147 chr6:88032118 GJB7;C6orf162 0.75 11.83 0.55 3.67e-27 Monocyte percentage of white cells; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg00699235 chr12:49962218 MCRS1 0.51 6.62 0.34 1.48e-10 Thyroid stimulating hormone; CRC cis rs7666738 0.830 rs7659593 chr4:98934823 T/C cg05340658 chr4:99064831 C4orf37 0.6 9.35 0.46 1.41e-18 Colonoscopy-negative controls vs population controls; CRC cis rs11098499 0.863 rs10030660 chr4:120436704 G/A cg09307838 chr4:120376055 NA 0.68 10.31 0.49 8.96e-22 Corneal astigmatism; CRC cis rs7223966 1.000 rs8078862 chr17:61854068 C/T cg05941027 chr17:61774174 LIMD2 0.35 6.3 0.33 9.71e-10 Hip circumference adjusted for BMI;Body mass index; CRC cis rs911555 0.706 rs10129426 chr14:104018455 C/T cg24130564 chr14:104152367 KLC1 -0.53 -8.3 -0.42 2.63e-15 Intelligence (multi-trait analysis); CRC cis rs447735 0.507 rs11645271 chr16:89729125 G/T cg03605463 chr16:89740564 NA -0.46 -7.45 -0.38 8.24e-13 Hemoglobin concentration; CRC cis rs2179367 0.919 rs577001 chr6:149646308 C/T cg11245181 chr6:149772854 ZC3H12D -0.41 -6.15 -0.32 2.19e-9 Dupuytren's disease; CRC cis rs9326248 0.520 rs236919 chr11:117095361 A/G cg15534755 chr11:117069859 TAGLN 0.29 5.76 0.3 1.96e-8 Blood protein levels; CRC cis rs66573146 0.656 rs111560662 chr4:6952766 C/T cg00086871 chr4:6988644 TBC1D14 0.91 7.75 0.39 1.14e-13 Granulocyte percentage of myeloid white cells; CRC cis rs362272 0.524 rs2749781 chr4:3346617 T/C cg14583973 chr4:3374767 RGS12 0.29 5.61 0.3 4.35e-8 Serum sulfate level; CRC trans rs4618210 0.722 rs1806555 chr3:17016794 G/T cg12886066 chr13:90015518 NA 0.48 6.46 0.34 3.67e-10 Myocardial infarction; CRC cis rs1580019 0.844 rs1901202 chr7:32503724 A/T cg06627557 chr7:32535165 LSM5;AVL9 0.85 13.48 0.6 2.83e-33 Cognitive ability; CRC cis rs754466 0.580 rs1058198 chr10:79566632 G/A cg26805224 chr10:79626177 DLG5 -0.45 -6.69 -0.35 9.47e-11 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs7131987 0.868 rs11050151 chr12:29403008 T/A cg09582351 chr12:29534625 ERGIC2 -0.28 -6.12 -0.32 2.62e-9 QT interval; CRC trans rs8141529 0.507 rs5762936 chr22:29381377 A/G cg25952886 chr17:31320651 SPACA3 -0.58 -6.81 -0.35 4.7e-11 Lymphocyte counts; CRC trans rs16846053 0.786 rs62187567 chr2:162363066 G/A cg27113153 chr11:123612418 ZNF202 -0.72 -6.17 -0.32 1.96e-9 Blood osmolality (transformed sodium); CRC cis rs11255291 0.668 rs4749169 chr10:7737661 G/C cg00997801 chr10:7671259 ITIH5 0.41 6.09 0.32 3.14e-9 Ovarian reserve; CRC cis rs7937682 0.924 rs501089 chr11:111502479 G/T cg19812747 chr11:111475976 SIK2 0.55 9.11 0.45 8e-18 Primary sclerosing cholangitis; CRC trans rs2078087 1.000 rs11577151 chr1:183381795 A/G cg14266927 chr14:75987682 BATF -0.61 -6.35 -0.33 7.1e-10 Obesity-related traits; CRC cis rs9467711 0.651 rs7749414 chr6:26074884 G/T cg19084075 chr6:26124329 HIST1H2AC;HIST1H2BC 0.76 6.62 0.34 1.48e-10 Autism spectrum disorder or schizophrenia; CRC cis rs7725052 0.609 rs10044710 chr5:40444472 A/G cg09067459 chr5:40385259 NA -0.39 -6.44 -0.33 4.31e-10 Pediatric autoimmune diseases; CRC cis rs2019137 0.936 rs12612729 chr2:113957048 G/A cg19083407 chr2:113993142 PAX8;LOC440839;LOC654433 -0.46 -6.45 -0.34 4e-10 Lymphocyte counts; CRC cis rs6860806 0.507 rs272882 chr5:131669161 G/T cg11843238 chr5:131593191 PDLIM4 0.42 7.25 0.37 3.07e-12 Breast cancer; CRC cis rs7937682 0.737 rs663763 chr11:111422217 C/T cg19812747 chr11:111475976 SIK2 -0.47 -7.79 -0.39 8.56e-14 Primary sclerosing cholangitis; CRC cis rs6951245 0.572 rs74791540 chr7:1061913 C/A cg24642844 chr7:1081250 C7orf50 -0.94 -8.05 -0.41 1.53e-14 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs6951245 1.000 rs11763020 chr7:1060288 C/T cg18402987 chr7:1209562 NA 0.59 6.2 0.32 1.67e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs2739330 0.731 rs4822450 chr22:24242887 C/T cg18538332 chr22:24372958 LOC391322 -0.68 -10.51 -0.5 1.85e-22 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs453301 0.686 rs13252797 chr8:8861430 A/G cg14979609 chr8:8086686 FLJ10661 -0.36 -5.81 -0.3 1.5e-8 Joint mobility (Beighton score); CRC cis rs1506636 0.962 rs629474 chr7:123399684 C/T cg03229431 chr7:123269106 ASB15 0.73 11.64 0.54 1.85e-26 Plateletcrit;Platelet count; CRC cis rs875971 0.838 rs2173570 chr7:65762963 T/A cg11764359 chr7:65958608 NA -0.62 -10.01 -0.48 9.02e-21 Aortic root size; CRC cis rs13064411 0.696 rs9839921 chr3:113199093 G/C cg18753928 chr3:113234510 CCDC52 -0.7 -10.83 -0.51 1.45e-23 Response to simvastatin treatment (PCSK9 protein level change); CRC trans rs2228479 1.000 rs12596492 chr16:89957169 T/G cg24644049 chr4:85504048 CDS1 0.91 7.97 0.4 2.59e-14 Skin colour saturation; CRC cis rs4713118 0.513 rs149951 chr6:28033087 T/C cg21251018 chr6:28226885 NKAPL 0.47 7.29 0.37 2.36e-12 Parkinson's disease; CRC cis rs9457247 0.967 rs1794694 chr6:167404751 T/C cg23791538 chr6:167370224 RNASET2 -0.38 -5.94 -0.31 7.32e-9 Crohn's disease; CRC cis rs35110281 0.807 rs28840140 chr21:45039163 T/C cg01579765 chr21:45077557 HSF2BP -0.36 -6.76 -0.35 6.2e-11 Mean corpuscular volume; CRC cis rs1983891 1.000 rs2104506 chr6:41533579 C/A cg20194872 chr6:41519635 FOXP4 0.39 5.65 0.3 3.56e-8 Prostate cancer; CRC cis rs9467711 0.606 rs9348712 chr6:26366511 T/A cg16898833 chr6:26189333 HIST1H4D 0.76 6.58 0.34 1.88e-10 Autism spectrum disorder or schizophrenia; CRC cis rs694739 0.628 rs11606081 chr11:64137875 T/C cg23796481 chr11:64053134 BAD;GPR137 0.48 6.73 0.35 7.42e-11 Alopecia areata;Crohn's disease;Psoriasis vulgaris; CRC cis rs6502050 0.761 rs11653003 chr17:80058795 G/T cg19223190 chr17:80058835 NA -0.49 -7.81 -0.4 7.58e-14 Life satisfaction; CRC cis rs4253772 0.701 rs9627280 chr22:46643964 T/C cg09491104 chr22:46646882 C22orf40 -0.43 -7.15 -0.37 5.66e-12 LDL cholesterol;Cholesterol, total; CRC cis rs4819052 0.819 rs13046807 chr21:46672286 A/G cg19498844 chr21:46707878 POFUT2;LOC642852 0.72 10.43 0.5 3.44e-22 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs28386778 0.897 rs1982400 chr17:61793818 T/C cg23090583 chr17:61904693 PSMC5;FTSJ3 0.99 18.31 0.71 3.83e-52 Prudent dietary pattern; CRC cis rs7071206 0.853 rs57420220 chr10:79428886 C/T cg07817648 chr10:79422355 NA -0.7 -8.68 -0.43 1.86e-16 Bone mineral density; CRC trans rs61931739 0.817 rs10772144 chr12:34242463 A/C cg26384229 chr12:38710491 ALG10B 0.43 5.99 0.31 5.4e-9 Morning vs. evening chronotype; CRC cis rs870825 0.587 rs35377170 chr4:185639728 T/C cg04058563 chr4:185651563 MLF1IP 0.73 9.41 0.46 9.01e-19 Blood protein levels; CRC cis rs10971721 0.822 rs72725398 chr9:33875918 A/T cg13495928 chr9:33750294 PRSS3 0.56 5.95 0.31 6.96e-9 Body mass index; CRC cis rs2842992 0.789 rs2277072 chr6:160182845 A/G cg16489826 chr6:160211363 TCP1;MRPL18 0.49 6.15 0.32 2.22e-9 Age-related macular degeneration (geographic atrophy); CRC cis rs6461049 0.765 rs1476887 chr7:2151633 T/C cg08027265 chr7:2291960 NA -0.37 -6.31 -0.33 9.07e-10 Schizophrenia; CRC cis rs1552244 1.000 rs4260416 chr3:10125283 C/T cg00166722 chr3:10149974 C3orf24 0.67 9.32 0.46 1.71e-18 Alzheimer's disease; CRC cis rs1129187 0.755 rs3818554 chr6:42934620 C/T cg09436375 chr6:42928200 GNMT -0.35 -6.6 -0.34 1.62e-10 Alzheimer's disease in APOE e4+ carriers; CRC cis rs6089584 0.888 rs6587283 chr20:60613727 A/C cg23262073 chr20:60523788 NA -0.47 -7.33 -0.37 1.76e-12 Body mass index; CRC cis rs7618915 0.501 rs2289247 chr3:52727257 C/T cg18404041 chr3:52824283 ITIH1 -0.39 -8.07 -0.41 1.35e-14 Bipolar disorder; CRC cis rs4713118 0.513 rs149958 chr6:28013617 A/C cg10876282 chr6:28092338 ZSCAN16 0.49 6.57 0.34 1.99e-10 Parkinson's disease; CRC cis rs6545883 0.868 rs6752938 chr2:61841588 C/T cg15711740 chr2:61764176 XPO1 -0.51 -7.01 -0.36 1.36e-11 Tuberculosis; CRC cis rs2130392 0.926 rs7677893 chr4:185625523 T/C cg04058563 chr4:185651563 MLF1IP 0.39 5.8 0.3 1.52e-8 Kawasaki disease; CRC trans rs9929218 0.679 rs9924886 chr16:68743939 A/C cg04657470 chr2:198365150 HSPE1;HSPD1 -0.96 -13.31 -0.59 1.28e-32 Colorectal cancer; CRC cis rs9318086 0.648 rs9510927 chr13:24467641 T/C cg25267304 chr13:24462978 PCOTH;MIPEP 0.67 11.01 0.52 3.18e-24 Myopia (pathological); CRC cis rs62229266 0.659 rs2835243 chr21:37413946 C/T cg08632701 chr21:37451849 NA -0.41 -6.41 -0.33 5.02e-10 Mitral valve prolapse; CRC cis rs35306767 0.859 rs11817793 chr10:878895 C/T cg26597838 chr10:835615 NA 0.91 11.05 0.52 2.45e-24 Eosinophil percentage of granulocytes; CRC cis rs1552244 0.572 rs7645759 chr3:10157368 C/T cg18598329 chr3:10140678 FANCD2;C3orf24 -0.9 -10.53 -0.5 1.57e-22 Alzheimer's disease; CRC cis rs875971 1.000 rs2077593 chr7:65892530 A/G cg00343986 chr7:65444356 GUSB 0.44 6.33 0.33 8.22e-10 Aortic root size; CRC cis rs6834538 0.520 rs11943167 chr4:113414179 G/A cg10021238 chr4:113569128 MIR367;LARP7 -0.36 -5.65 -0.3 3.55e-8 Free thyroxine concentration; CRC cis rs909002 0.772 rs10798876 chr1:32074514 C/G cg13919466 chr1:32135498 COL16A1 -0.31 -5.79 -0.3 1.67e-8 Intelligence (multi-trait analysis); CRC cis rs7666738 0.830 rs7697315 chr4:98938764 T/C cg17366294 chr4:99064904 C4orf37 0.43 7.23 0.37 3.47e-12 Colonoscopy-negative controls vs population controls; CRC cis rs8072100 0.811 rs9889709 chr17:45445229 C/T cg25173405 chr17:45401733 C17orf57 -0.52 -8.46 -0.42 8.74e-16 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg25621096 chr1:151032116 CDC42SE1;MLLT11 -0.39 -6.34 -0.33 7.71e-10 Myopia (pathological); CRC cis rs17253792 0.822 rs10147380 chr14:56054354 T/C cg24579896 chr14:56047964 C14orf33;KTN1 0.67 5.7 0.3 2.61e-8 Putamen volume; CRC cis rs1577917 1.000 rs34581302 chr6:86705948 G/A cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.53 -6.64 -0.34 1.32e-10 Response to antipsychotic treatment; CRC cis rs1506636 1.000 rs2402669 chr7:123297460 C/G cg03229431 chr7:123269106 ASB15 -0.78 -12.41 -0.56 2.79e-29 Plateletcrit;Platelet count; CRC cis rs5760092 0.755 rs915589 chr22:24261004 C/T cg11905131 chr22:24372483 LOC391322 0.58 6.23 0.32 1.44e-9 Urinary 1,3-butadiene metabolite levels in smokers; CRC cis rs1865760 0.865 rs10946800 chr6:25957773 C/T cg16482183 chr6:26056742 HIST1H1C 0.55 8.06 0.41 1.44e-14 Height; CRC cis rs35883536 0.669 rs1932352 chr1:101161251 G/A cg14515779 chr1:101123966 NA 0.35 5.88 0.31 1.03e-8 Monocyte count; CRC trans rs7395662 0.500 rs1605360 chr11:48685714 G/A cg15704280 chr7:45808275 SEPT13 -0.52 -7.47 -0.38 7.28e-13 HDL cholesterol; CRC cis rs9611565 0.559 rs132765 chr22:42008068 A/G cg03806693 chr22:41940476 POLR3H 1.03 11.7 0.54 1.15e-26 Vitiligo; CRC cis rs7945705 0.967 rs10769970 chr11:8917937 A/G cg21881798 chr11:8931708 C11orf17;ST5 0.67 10.28 0.49 1.09e-21 Hemoglobin concentration; CRC cis rs6456156 0.846 rs7774396 chr6:167519786 G/A cg07741184 chr6:167504864 NA 0.47 8.14 0.41 8.25e-15 Primary biliary cholangitis; CRC cis rs34330 0.562 rs10492235 chr12:12851339 T/G cg04607235 chr12:12878440 APOLD1 -0.69 -7.03 -0.36 1.23e-11 Systemic lupus erythematosus; CRC cis rs61996546 0.622 rs35521364 chr15:26867145 G/A cg15066197 chr15:26874202 GABRB3 -0.39 -5.99 -0.31 5.37e-9 Response to methotrexate in juvenile idiopathic arthritis; CRC cis rs2836974 0.897 rs14194 chr21:40549466 T/C cg06238570 chr21:40685208 BRWD1 0.78 10.76 0.51 2.51e-23 Cognitive function; CRC cis rs2404602 0.608 rs12439484 chr15:76602937 A/C cg22467129 chr15:76604101 ETFA -0.49 -8.72 -0.43 1.41e-16 Blood metabolite levels; CRC cis rs875971 0.964 rs12668936 chr7:65914404 C/T cg12463550 chr7:65579703 CRCP 0.48 6.78 0.35 5.56e-11 Aortic root size; CRC cis rs877282 0.583 rs11253428 chr10:823233 C/T cg17470449 chr10:769945 NA 0.51 7.05 0.36 1.03e-11 Uric acid levels; CRC trans rs7618501 0.735 rs9876508 chr3:49780844 G/A cg21659725 chr3:3221576 CRBN -0.9 -17.3 -0.69 3.95e-48 Intelligence (multi-trait analysis); CRC cis rs7591163 1.000 rs6738964 chr2:228739135 G/T cg14329157 chr2:228736135 WDR69 -0.48 -6.72 -0.35 8.19e-11 Blood pressure; CRC cis rs3617 0.539 rs4687687 chr3:52948332 A/G cg07507251 chr3:52567010 NT5DC2 -0.41 -6.27 -0.33 1.12e-9 Red blood cell count;Autism spectrum disorder or schizophrenia; CRC cis rs7731657 0.510 rs10045858 chr5:130251039 C/T cg08523029 chr5:130500466 HINT1 0.42 5.65 0.3 3.47e-8 Fasting plasma glucose; CRC cis rs4665809 1.000 rs4665809 chr2:26251361 C/T cg04944784 chr2:26401820 FAM59B 0.59 7.38 0.38 1.3e-12 Gut microbiome composition (summer); CRC cis rs2976388 0.556 rs4736323 chr8:143830359 C/T cg24634471 chr8:143751801 JRK -0.46 -6.14 -0.32 2.35e-9 Urinary tract infection frequency; CRC cis rs4888630 0.596 rs7185964 chr16:77484585 A/C cg10121788 chr16:77469583 ADAMTS18 -0.33 -5.94 -0.31 7.12e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs60871478 1.000 rs34086011 chr7:805430 C/T cg04727924 chr7:799746 HEATR2 -0.45 -6.77 -0.35 6e-11 Cerebrospinal P-tau181p levels; CRC trans rs12599106 0.818 rs17723574 chr16:34602945 C/G cg21548813 chr6:291882 DUSP22 -0.51 -7.24 -0.37 3.16e-12 Menopause (age at onset); CRC cis rs8044995 0.501 rs73613999 chr16:68390099 C/A cg09835421 chr16:68378352 PRMT7 -0.75 -7.99 -0.4 2.25e-14 Schizophrenia; CRC cis rs58688157 0.705 rs7112149 chr11:595890 G/A cg16486109 chr11:613632 IRF7 0.74 12.49 0.57 1.41e-29 Systemic lupus erythematosus; CRC cis rs2019137 0.560 rs7421852 chr2:113990261 G/A cg07772999 chr2:113993052 PAX8;LOC440839;LOC654433 0.57 8.45 0.42 9.72e-16 Lymphocyte counts; CRC cis rs6762 0.719 rs1130698 chr11:838542 C/T cg16425592 chr11:842748 TSPAN4;POLR2L -0.54 -7.7 -0.39 1.6e-13 Mean platelet volume; CRC cis rs12410462 0.681 rs79461024 chr1:227568783 G/T cg23173402 chr1:227635558 NA 0.7 6.36 0.33 6.68e-10 Major depressive disorder; CRC cis rs698833 0.926 rs1067399 chr2:44678648 A/G cg04920474 chr2:44395004 PPM1B 0.42 6.2 0.32 1.73e-9 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; CRC cis rs4713118 0.955 rs9393847 chr6:27687973 G/A cg25164649 chr6:28176230 NA 0.57 7.55 0.38 4.3e-13 Parkinson's disease; CRC cis rs9467711 0.651 rs66790453 chr6:26107088 C/T cg08501292 chr6:25962987 TRIM38 0.65 6.33 0.33 8.03e-10 Autism spectrum disorder or schizophrenia; CRC cis rs875971 1.000 rs6963646 chr7:65685767 T/C cg11764359 chr7:65958608 NA -0.62 -9.98 -0.48 1.2e-20 Aortic root size; CRC cis rs7666738 0.830 rs17026973 chr4:98680041 T/A cg05340658 chr4:99064831 C4orf37 0.56 8.43 0.42 1.12e-15 Colonoscopy-negative controls vs population controls; CRC cis rs6540556 0.736 rs2076152 chr1:209936060 A/G cg23920097 chr1:209922102 NA -0.5 -6.49 -0.34 3.25e-10 Red blood cell count; CRC cis rs2836974 0.899 rs114399588 chr21:40653958 G/A cg07074390 chr21:40555500 PSMG1 -0.45 -6.03 -0.32 4.5e-9 Cognitive function; CRC cis rs9611565 0.879 rs5758307 chr22:41750219 A/G cg03806693 chr22:41940476 POLR3H -0.73 -10.38 -0.5 5.17e-22 Vitiligo; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg17174230 chr11:65337779 SSSCA1 0.46 6.38 0.33 6.04e-10 Anxiety disorder; CRC cis rs9372498 0.536 rs62421539 chr6:118730559 C/A cg15382696 chr6:118971807 C6orf204 0.59 7.64 0.39 2.45e-13 Diastolic blood pressure; CRC cis rs4665809 1.000 rs1560868 chr2:26281459 A/T cg26119090 chr2:26468346 HADHA;HADHB 0.6 7.63 0.39 2.55e-13 Gut microbiome composition (summer); CRC cis rs4862750 0.794 rs7672272 chr4:187896774 T/G cg06074448 chr4:187884817 NA -0.58 -10.81 -0.51 1.71e-23 Lobe attachment (rater-scored or self-reported); CRC cis rs1983170 0.778 rs906241 chr1:92012154 G/T cg22013790 chr1:91990662 CDC7 0.43 5.84 0.31 1.23e-8 Eosinophil percentage of white cells; CRC cis rs780096 0.506 rs1647285 chr2:27714511 A/C cg17158414 chr2:27665306 KRTCAP3 -0.32 -7.17 -0.37 5.01e-12 Total body bone mineral density; CRC cis rs4731207 0.596 rs7810654 chr7:124645089 G/A cg23710748 chr7:124431027 NA -0.39 -6.25 -0.33 1.24e-9 Cutaneous malignant melanoma; CRC cis rs3091242 0.933 rs10903129 chr1:25768937 A/G cg23205692 chr1:25664452 TMEM50A 0.4 5.68 0.3 3e-8 Erythrocyte sedimentation rate; CRC cis rs13315871 1.000 rs35621601 chr3:58323174 A/G cg20936604 chr3:58311152 NA -0.76 -7.27 -0.37 2.69e-12 Cholesterol, total; CRC cis rs447735 0.587 rs258336 chr16:89720831 A/C cg03605463 chr16:89740564 NA 0.47 7.5 0.38 5.99e-13 Hemoglobin concentration; CRC cis rs7428 0.527 rs3184780 chr2:85549547 C/T cg24342717 chr2:85555507 TGOLN2 -0.72 -11.94 -0.55 1.5e-27 Ear protrusion; CRC trans rs365060 0.630 rs260705 chr2:109571440 A/G cg18385501 chr17:73401976 GRB2 0.5 6.38 0.33 5.96e-10 Beard thickness; CRC cis rs1707322 1.000 rs4660906 chr1:46470860 C/T cg03146154 chr1:46216737 IPP 0.49 6.86 0.35 3.35e-11 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs7618915 0.501 rs3733041 chr3:52731598 T/C cg10802521 chr3:52805072 NEK4 -0.58 -9.15 -0.45 5.92e-18 Bipolar disorder; CRC cis rs2952156 0.920 rs12940986 chr17:37836581 A/G cg00129232 chr17:37814104 STARD3 0.71 12.73 0.57 1.9e-30 Asthma; CRC cis rs25422 0.938 rs114309775 chr6:118838782 G/A cg01339444 chr6:118972232 C6orf204 0.53 6.03 0.32 4.29e-9 Renal cell carcinoma; CRC cis rs1799949 1.000 rs8070085 chr17:41341984 C/T cg19454999 chr17:41278357 BRCA1;NBR2 -0.48 -7.53 -0.38 4.98e-13 Menopause (age at onset); CRC cis rs4654899 0.931 rs58762579 chr1:21257831 G/A cg02927042 chr1:21476669 EIF4G3 -0.46 -7.3 -0.37 2.19e-12 Superior frontal gyrus grey matter volume; CRC cis rs2153535 0.580 rs7766852 chr6:8472417 C/T cg07606381 chr6:8435919 SLC35B3 0.67 10.73 0.51 3.04e-23 Motion sickness; CRC cis rs7586879 0.663 rs6760328 chr2:25077991 T/C cg04586622 chr2:25135609 ADCY3 -0.51 -8.32 -0.42 2.39e-15 Body mass index; CRC cis rs7647973 0.560 rs62262671 chr3:49649873 A/G cg20833759 chr3:49053208 WDR6;DALRD3 -0.54 -6.13 -0.32 2.53e-9 Menarche (age at onset); CRC cis rs1878931 0.597 rs37814 chr16:3455247 C/T cg26668626 chr16:3451006 ZNF174;ZNF434 -0.58 -6.94 -0.36 2.07e-11 Body mass index (adult); CRC cis rs10504229 1.000 rs73609764 chr8:58192971 G/A cg24829409 chr8:58192753 C8orf71 -0.68 -11.34 -0.53 2.27e-25 Developmental language disorder (linguistic errors); CRC cis rs736408 0.812 rs746694 chr3:52826620 C/T cg05573699 chr3:52720067 GNL3;PBRM1 -0.42 -5.76 -0.3 1.89e-8 Bipolar disorder; CRC cis rs7762018 0.943 rs11546265 chr6:170108363 G/A cg19338460 chr6:170058176 WDR27 -0.73 -7.89 -0.4 4.53e-14 Thiazide-induced adverse metabolic effects in hypertensive patients; CRC cis rs6088813 1.000 rs6142369 chr20:33973315 T/G cg14752227 chr20:34000481 UQCC -0.37 -5.6 -0.3 4.46e-8 Height; CRC cis rs1448094 0.842 rs12318815 chr12:86452281 T/C cg18827107 chr12:86230957 RASSF9 0.37 5.95 0.31 6.93e-9 Major depressive disorder; CRC cis rs3812762 0.871 rs3844100 chr11:8817808 A/G cg00186954 chr11:8933980 ST5;C11orf17 0.38 6.27 0.33 1.11e-9 Hypospadias; CRC cis rs12505749 0.542 rs4618376 chr4:57345659 G/A cg06922635 chr4:57371607 ARL9 -0.54 -5.7 -0.3 2.66e-8 Airflow obstruction; CRC trans rs1814175 0.869 rs10769600 chr11:49681832 C/T cg11707556 chr5:10655725 ANKRD33B -0.43 -7.95 -0.4 3.11e-14 Height; CRC cis rs826838 1.000 rs6582619 chr12:38729904 A/G cg13010199 chr12:38710504 ALG10B 0.47 6.05 0.32 4.05e-9 Heart rate; CRC cis rs2019137 0.967 rs895412 chr2:113973964 T/C cg19083407 chr2:113993142 PAX8;LOC440839;LOC654433 -0.47 -6.7 -0.35 9.26e-11 Lymphocyte counts; CRC cis rs9910055 0.529 rs228746 chr17:42173752 T/C cg10896456 chr17:42255109 ASB16;C17orf65 -0.4 -6.14 -0.32 2.38e-9 Total body bone mineral density; CRC cis rs11229555 0.609 rs12273517 chr11:58201094 C/T cg15696309 chr11:58395628 NA -0.82 -10.31 -0.49 8.59e-22 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; CRC cis rs10504229 0.679 rs11786328 chr8:58039269 A/G cg22535103 chr8:58192502 C8orf71 -0.68 -7.46 -0.38 7.93e-13 Developmental language disorder (linguistic errors); CRC cis rs629535 0.814 rs62513373 chr8:70080753 C/T cg26132723 chr8:70041827 NA -0.35 -5.63 -0.3 3.87e-8 Dupuytren's disease; CRC trans rs4698169 0.510 rs675984 chr4:17123821 A/G cg17378563 chr5:133861150 PHF15 -0.68 -6.11 -0.32 2.87e-9 Temperament (bipolar disorder); CRC cis rs2530545 0.502 rs2125404 chr7:34697388 C/T cg14401837 chr7:34697493 NPSR1 -0.6 -7.3 -0.37 2.15e-12 IgG glycosylation; CRC cis rs9487051 0.768 rs9398188 chr6:109526615 G/A cg21918786 chr6:109611834 NA -0.35 -5.94 -0.31 7.08e-9 Reticulocyte fraction of red cells; CRC cis rs9467711 0.606 rs2235251 chr6:26431982 C/T cg12315302 chr6:26189340 HIST1H4D 0.82 6.33 0.33 8.12e-10 Autism spectrum disorder or schizophrenia; CRC cis rs7408868 0.831 rs1548555 chr19:15278057 A/G cg14696996 chr19:15285081 NOTCH3 0.96 9.0 0.44 1.82e-17 Pulse pressure; CRC trans rs916888 0.610 rs142167 chr17:44795234 C/T cg22968622 chr17:43663579 NA -0.86 -11.25 -0.53 4.48e-25 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC trans rs1814175 0.817 rs4881658 chr11:49941123 G/A cg03929089 chr4:120376271 NA -0.94 -17.67 -0.7 1.39e-49 Height; CRC cis rs12681287 0.547 rs13261956 chr8:87478765 G/A cg27223183 chr8:87520930 FAM82B -0.53 -7.42 -0.38 1.01e-12 Caudate activity during reward; CRC cis rs10876993 0.890 rs1689584 chr12:58081478 G/A cg18357645 chr12:58087776 OS9 0.63 8.97 0.44 2.28e-17 Celiac disease or Rheumatoid arthritis; CRC cis rs2762353 0.595 rs12207270 chr6:25751721 A/G cg15691649 chr6:25882328 NA -0.48 -6.43 -0.33 4.5e-10 Blood metabolite levels; CRC cis rs13191362 0.935 rs7763118 chr6:162954720 A/G cg14584255 chr6:163149320 PACRG;PARK2 0.38 5.64 0.3 3.58e-8 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs7216064 1.000 rs11079707 chr17:65835617 A/G cg12091567 chr17:66097778 LOC651250 0.58 6.78 0.35 5.41e-11 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CRC cis rs72945132 0.941 rs66803755 chr11:70117473 G/A cg00319359 chr11:70116639 PPFIA1 0.75 7.68 0.39 1.88e-13 Coronary artery disease; CRC cis rs9527 0.615 rs7089065 chr10:104723022 C/T cg04362960 chr10:104952993 NT5C2 0.6 8.59 0.43 3.61e-16 Arsenic metabolism; CRC cis rs8077889 0.956 rs17742347 chr17:41846468 A/G cg16892393 chr17:41919603 NA -0.5 -6.88 -0.35 3.06e-11 Triglycerides; CRC cis rs6696846 0.749 rs7553876 chr1:205079915 A/G cg00857998 chr1:205179979 DSTYK 0.41 5.76 0.3 1.96e-8 Red blood cell count; CRC cis rs9322193 0.923 rs9377230 chr6:149934743 T/C cg13206674 chr6:150067644 NUP43 0.64 9.7 0.47 9.87e-20 Lung cancer; CRC cis rs3126085 0.935 rs4845740 chr1:152183310 G/A cg09127314 chr1:152161683 NA 0.51 6.4 0.33 5.3e-10 Atopic dermatitis; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg08763126 chr6:109416997 C6orf182 0.46 6.57 0.34 2.02e-10 Response to antipsychotic treatment; CRC cis rs10464366 0.544 rs9639812 chr7:39192058 C/T cg18850127 chr7:39170497 POU6F2 0.57 7.43 0.38 9.25e-13 IgG glycosylation; CRC cis rs282587 0.569 rs4907750 chr13:113391348 C/A cg04656015 chr13:113407548 ATP11A 0.57 7.41 0.38 1.07e-12 Glycated hemoglobin levels; CRC trans rs10983614 1.000 rs7867776 chr9:120072627 A/G cg10053149 chr1:28908509 SNHG12;SNORA44;SNORA16A 0.48 6.61 0.34 1.54e-10 Survival in pancreatic cancer; CRC cis rs9311474 0.713 rs352166 chr3:52238677 C/T cg15147215 chr3:52552868 STAB1 -0.5 -8.09 -0.41 1.17e-14 Electroencephalogram traits; CRC cis rs2992756 0.553 rs2992745 chr1:18809896 A/T cg14356550 chr1:18808102 KLHDC7A -0.38 -5.76 -0.3 1.92e-8 Breast cancer; CRC trans rs2243480 1.000 rs1267820 chr7:66050295 C/G cg10756647 chr7:56101905 PSPH 0.76 7.86 0.4 5.47e-14 Diabetic kidney disease; CRC cis rs6011002 0.636 rs1758199 chr20:62352827 T/C cg01176363 chr20:62369445 LIME1 -0.72 -5.67 -0.3 3.18e-8 Dental caries; CRC cis rs7107174 1.000 rs12270434 chr11:78103300 G/A cg02023728 chr11:77925099 USP35 0.46 7.78 0.39 9.53e-14 Testicular germ cell tumor; CRC cis rs6424115 0.830 rs2503002 chr1:24196957 C/G cg15997130 chr1:24165203 NA 0.68 10.02 0.48 8.55e-21 Immature fraction of reticulocytes; CRC cis rs6066835 0.867 rs6095277 chr20:47363257 A/G cg18078177 chr20:47281410 PREX1 -0.61 -5.8 -0.3 1.56e-8 Multiple myeloma; CRC cis rs2795502 0.702 rs3123750 chr10:43227824 C/A cg20628663 chr10:43360327 NA -0.56 -6.99 -0.36 1.53e-11 Blood protein levels; CRC cis rs4716602 0.596 rs13221649 chr7:156160793 G/A cg16983916 chr7:156159713 NA -0.39 -6.9 -0.36 2.65e-11 Anti-saccade response; CRC cis rs79387448 0.745 rs72995626 chr2:103162580 T/C cg09003973 chr2:102972529 NA 0.73 8.01 0.4 1.97e-14 Gut microbiota (bacterial taxa); CRC cis rs28386778 0.897 rs2584639 chr17:61863732 C/T cg11494091 chr17:61959527 GH2 0.59 10.04 0.48 7.33e-21 Prudent dietary pattern; CRC cis rs1150668 0.768 rs1233713 chr6:28198281 A/G cg12172441 chr6:28176163 NA 0.43 6.3 0.33 9.3e-10 Pubertal anthropometrics; CRC cis rs61774743 0.636 rs1892423 chr1:41849340 A/C cg00290994 chr1:41848739 NA 0.53 7.99 0.4 2.34e-14 Intelligence (multi-trait analysis); CRC cis rs4332037 0.552 rs11773627 chr7:2002733 A/G cg23422044 chr7:1970798 MAD1L1 -0.56 -7.22 -0.37 3.62e-12 Bipolar disorder; CRC cis rs4319547 0.656 rs10773088 chr12:122828069 A/T cg23029597 chr12:123009494 RSRC2 -0.51 -6.24 -0.33 1.32e-9 Body mass index; CRC cis rs8060686 0.641 rs8044014 chr16:68209872 T/C cg08314208 chr16:67682810 RLTPR -0.48 -5.79 -0.3 1.64e-8 HDL cholesterol;Metabolic syndrome; CRC cis rs34172651 0.517 rs8059004 chr16:24837905 G/A cg02428538 chr16:24856791 SLC5A11 -0.54 -6.32 -0.33 8.53e-10 Intelligence (multi-trait analysis); CRC cis rs7945705 0.791 rs10769958 chr11:8815115 T/C cg12365402 chr11:9010492 NRIP3 -0.38 -6.55 -0.34 2.17e-10 Hemoglobin concentration; CRC cis rs11148252 0.846 rs7985262 chr13:52997161 C/T cg00495681 chr13:53174319 NA 0.57 8.54 0.43 4.9e-16 Lewy body disease; CRC trans rs12478296 0.581 rs56142391 chr2:242992248 C/T cg18288967 chr1:45987694 PRDX1 0.63 7.54 0.38 4.53e-13 Obesity-related traits; CRC cis rs1153858 1.000 rs12591058 chr15:45640172 T/C cg21132104 chr15:45694354 SPATA5L1 0.58 8.61 0.43 3.09e-16 Homoarginine levels; CRC cis rs4601821 0.635 rs11214579 chr11:113208186 A/C cg14159747 chr11:113255604 NA -0.43 -7.82 -0.4 7.11e-14 Alcoholic chronic pancreatitis; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg15747848 chr15:40074985 FSIP1 0.48 7.0 0.36 1.44e-11 Intelligence (multi-trait analysis); CRC cis rs6951245 0.938 rs112425403 chr7:1071531 A/G cg18402987 chr7:1209562 NA 0.63 6.7 0.35 8.96e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg14481911 chr2:242438436 STK25 -0.37 -6.19 -0.32 1.83e-9 Liver disease severity in Alagille syndrome; CRC cis rs13108904 0.935 rs2199956 chr4:1248919 A/G cg21620606 chr4:1342894 KIAA1530 0.41 7.23 0.37 3.38e-12 Obesity-related traits; CRC cis rs9487051 0.714 rs6927569 chr6:109621494 T/C cg01475377 chr6:109611718 NA -0.38 -6.66 -0.34 1.17e-10 Reticulocyte fraction of red cells; CRC cis rs12545109 0.765 rs2576594 chr8:57412126 T/G cg09654669 chr8:57350985 NA -0.4 -5.68 -0.3 2.99e-8 Obesity-related traits; CRC cis rs11191205 0.774 rs11191203 chr10:103824920 C/T cg15320455 chr10:103880129 LDB1 0.66 7.16 0.37 5.18e-12 Intelligence (multi-trait analysis); CRC cis rs798554 0.757 rs2533882 chr7:2846894 G/T cg17321639 chr7:2759063 NA -0.54 -7.14 -0.37 6.2e-12 Height; CRC trans rs7395662 0.711 rs11512405 chr11:48936357 C/T cg21153622 chr11:89784906 NA -0.49 -7.81 -0.4 7.62e-14 HDL cholesterol; CRC cis rs34779708 0.766 rs35308730 chr10:35549796 C/T cg03585969 chr10:35415529 CREM 0.5 6.39 0.33 5.83e-10 Inflammatory bowel disease;Crohn's disease; CRC cis rs4975616 0.807 rs28379291 chr5:1313701 A/G cg06550200 chr5:1325588 CLPTM1L 0.63 9.56 0.47 2.77e-19 Lung cancer; CRC cis rs798554 0.759 rs1182189 chr7:2869522 G/A cg04166393 chr7:2884313 GNA12 0.53 7.01 0.36 1.39e-11 Height; CRC cis rs2243480 0.706 rs34466769 chr7:65453292 A/C cg25985355 chr7:65971099 NA -0.44 -5.77 -0.3 1.83e-8 Diabetic kidney disease; CRC cis rs10504229 0.775 rs55825382 chr8:58157605 G/A cg21724239 chr8:58056113 NA 0.65 8.55 0.43 4.57e-16 Developmental language disorder (linguistic errors); CRC cis rs4862750 0.957 rs1030381 chr4:187903568 G/C cg22105103 chr4:187893119 NA 0.65 11.55 0.54 3.88e-26 Lobe attachment (rater-scored or self-reported); CRC cis rs6120849 0.754 rs1885116 chr20:33600560 A/G cg24642439 chr20:33292090 TP53INP2 0.43 5.61 0.3 4.4e-8 Protein C levels; CRC cis rs1577917 0.958 rs7739241 chr6:86575796 A/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.51 -6.8 -0.35 5.07e-11 Response to antipsychotic treatment; CRC trans rs2228479 0.702 rs12600151 chr16:89831558 C/T cg24644049 chr4:85504048 CDS1 0.87 7.08 0.36 8.68e-12 Skin colour saturation; CRC cis rs9388451 0.505 rs6920965 chr6:126179111 G/A cg05901451 chr6:126070800 HEY2 -0.4 -5.83 -0.31 1.3e-8 Brugada syndrome; CRC cis rs11148252 0.514 rs9526843 chr13:52730056 C/T cg12458913 chr13:53173898 NA 0.39 5.7 0.3 2.62e-8 Lewy body disease; CRC cis rs4474465 0.703 rs10899547 chr11:78254720 C/T cg27205649 chr11:78285834 NARS2 0.49 6.23 0.32 1.41e-9 Alzheimer's disease (survival time); CRC cis rs7552404 0.731 rs11588578 chr1:76400539 T/G cg10523679 chr1:76189770 ACADM 0.66 8.06 0.41 1.38e-14 Blood metabolite levels;Acylcarnitine levels; CRC cis rs736408 0.522 rs6445535 chr3:52771468 T/C cg15147215 chr3:52552868 STAB1 -0.63 -10.74 -0.51 2.95e-23 Bipolar disorder; CRC trans rs11098499 0.909 rs7681214 chr4:120385320 C/A cg25214090 chr10:38739885 LOC399744 0.66 10.55 0.5 1.36e-22 Corneal astigmatism; CRC cis rs9858542 0.953 rs9827021 chr3:49514764 C/A cg00383909 chr3:49044727 WDR6 0.44 5.68 0.3 2.91e-8 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs6912958 0.781 rs7750207 chr6:88303967 A/C cg08069147 chr6:88032118 GJB7;C6orf162 -0.57 -8.57 -0.43 4.19e-16 Monocyte percentage of white cells; CRC cis rs13256369 0.802 rs1060107 chr8:8561399 G/T cg18904891 chr8:8559673 CLDN23 0.52 6.91 0.36 2.51e-11 Obesity-related traits; CRC cis rs10486722 0.624 rs11761217 chr7:41772275 C/T cg22138096 chr7:41772439 LOC285954 -0.39 -5.88 -0.31 1.02e-8 Pit-and-Fissure caries; CRC cis rs7208859 0.623 rs79607958 chr17:28934548 T/G cg01831904 chr17:28903510 LRRC37B2 -0.61 -6.09 -0.32 3.13e-9 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg04498580 chr4:140478204 SETD7 0.42 5.98 0.31 5.78e-9 Response to antipsychotic treatment; CRC cis rs514406 0.505 rs395169 chr1:53174071 G/A cg25767906 chr1:53392781 SCP2 -0.39 -5.98 -0.31 5.75e-9 Monocyte count; CRC trans rs6951245 1.000 rs74785791 chr7:1088494 T/C cg13565492 chr6:43139072 SRF -0.71 -7.12 -0.37 7.03e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs2066819 1.000 rs59626664 chr12:56636975 C/G cg26714650 chr12:56694279 CS -1.41 -11.64 -0.54 1.88e-26 Psoriasis vulgaris; CRC cis rs13256369 0.951 rs12679360 chr8:8566269 G/T cg00074818 chr8:8560427 CLDN23 -0.4 -7.04 -0.36 1.13e-11 Obesity-related traits; CRC cis rs10791323 0.576 rs4937840 chr11:133734322 C/G cg15485101 chr11:133734466 NA 0.46 7.89 0.4 4.41e-14 Childhood ear infection; CRC cis rs28386778 0.897 rs2044125 chr17:61863184 A/C cg25654072 chr17:61904446 PSMC5;FTSJ3 -0.71 -11.14 -0.52 1.15e-24 Prudent dietary pattern; CRC cis rs7819412 0.745 rs4841498 chr8:10985432 C/T cg27411982 chr8:10470053 RP1L1 -0.38 -5.86 -0.31 1.15e-8 Triglycerides; CRC cis rs34311866 0.808 rs4583705 chr4:973036 C/T cg14530993 chr4:882597 GAK 0.75 6.93 0.36 2.17e-11 Parkinson's disease; CRC cis rs28386778 0.863 rs2665834 chr17:61904724 T/C cg07362569 chr17:61921086 SMARCD2 0.38 5.95 0.31 6.92e-9 Prudent dietary pattern; CRC cis rs9926296 0.687 rs258317 chr16:89732238 C/T cg03605463 chr16:89740564 NA 0.62 9.56 0.47 2.77e-19 Vitiligo; CRC cis rs4824093 0.544 rs7410765 chr22:50315924 G/T cg22709217 chr22:50311962 ALG12;CRELD2 -0.88 -7.85 -0.4 5.86e-14 Amyotrophic lateral sclerosis (sporadic); CRC cis rs4919694 0.572 rs12243903 chr10:104906992 T/C cg04362960 chr10:104952993 NT5C2 0.88 9.11 0.45 8.21e-18 Arsenic metabolism; CRC cis rs1712517 0.744 rs11191641 chr10:105052940 C/T cg05636881 chr10:105038444 INA 0.47 8.08 0.41 1.23e-14 Migraine; CRC cis rs7412746 0.597 rs868751 chr1:150669414 T/G cg17724175 chr1:150552817 MCL1 0.61 9.75 0.47 6.57e-20 Melanoma; CRC trans rs875971 0.660 rs2191268 chr7:66110224 C/T cg04983606 chr1:178996021 FAM20B -0.4 -6.08 -0.32 3.3e-9 Aortic root size; CRC cis rs9486715 1.000 rs2273621 chr6:97058553 A/G cg18709589 chr6:96969512 KIAA0776 -0.52 -7.65 -0.39 2.31e-13 Headache; CRC cis rs1395 0.634 rs72817542 chr2:27526681 C/G cg23587288 chr2:27483067 SLC30A3 -0.42 -5.94 -0.31 7.27e-9 Blood metabolite levels; CRC cis rs4727027 0.933 rs6961605 chr7:148870108 G/A cg12479418 chr7:148823350 ZNF425;ZNF398 0.43 5.91 0.31 8.48e-9 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC cis rs9341808 0.718 rs10943696 chr6:80901272 C/G cg08355045 chr6:80787529 NA 0.43 6.94 0.36 2.08e-11 Sitting height ratio; CRC cis rs11203032 0.831 rs4417181 chr10:90967093 T/C cg16672925 chr10:90967113 CH25H 0.46 6.13 0.32 2.45e-9 Heart failure; CRC cis rs9584850 0.540 rs61969457 chr13:99176742 C/T cg20487152 chr13:99095054 FARP1 0.45 5.65 0.3 3.46e-8 Neuroticism; CRC cis rs28655083 1.000 rs1843456 chr16:77072393 A/G cg01753188 chr16:77233325 SYCE1L;MON1B -0.57 -8.0 -0.4 2.15e-14 Lobe attachment (rater-scored or self-reported); CRC cis rs908922 0.584 rs10888500 chr1:152532749 G/A cg23254163 chr1:152506842 NA 0.45 9.14 0.45 6.46e-18 Hair morphology; CRC cis rs1129187 0.720 rs9471972 chr6:42915021 G/A cg26304593 chr6:42947056 PEX6 -0.43 -6.16 -0.32 2.09e-9 Alzheimer's disease in APOE e4+ carriers; CRC cis rs1707322 0.721 rs28442079 chr1:46172001 A/G cg06784218 chr1:46089804 CCDC17 0.66 12.38 0.56 3.81e-29 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs2836974 0.897 rs34035316 chr21:40594023 T/C cg06238570 chr21:40685208 BRWD1 0.78 10.89 0.51 8.51e-24 Cognitive function; CRC cis rs2011503 1.000 rs8110171 chr19:19560063 C/T cg11584989 chr19:19387371 SF4 0.53 5.96 0.31 6.67e-9 Bipolar disorder; CRC cis rs6502050 0.835 rs8074267 chr17:80158325 A/G cg13198984 chr17:80129470 CCDC57 0.45 8.01 0.4 1.99e-14 Life satisfaction; CRC cis rs6918586 0.615 rs198841 chr6:26111671 G/T cg18357526 chr6:26021779 HIST1H4A -0.49 -7.4 -0.38 1.16e-12 Schizophrenia; CRC cis rs7945705 0.875 rs10769957 chr11:8809016 A/C cg21881798 chr11:8931708 C11orf17;ST5 -0.48 -6.99 -0.36 1.53e-11 Hemoglobin concentration; CRC trans rs9929218 0.906 rs9933844 chr16:68747001 G/A cg04657470 chr2:198365150 HSPE1;HSPD1 -0.92 -12.26 -0.56 1.02e-28 Colorectal cancer; CRC cis rs79839061 0.656 rs3775126 chr4:886345 C/T cg14530993 chr4:882597 GAK 0.79 7.79 0.39 8.83e-14 Intelligence (multi-trait analysis); CRC cis rs711830 0.965 rs2857532 chr2:177033283 A/G cg13092806 chr2:177043255 NA 0.73 8.76 0.43 1.07e-16 Serous invasive ovarian cancer;Epithelial ovarian cancer;Invasive epithelial ovarian cancer;Mucinous ovarian carcinoma;Low-grade serous and serous borderline ovarian cancer;Serous borderline ovarian cancer;High-grade serous ovarian cancer; CRC cis rs6938 0.534 rs11636892 chr15:75266049 G/C cg05627522 chr15:75251581 NA 0.5 7.58 0.39 3.59e-13 Breast cancer; CRC cis rs6952808 0.689 rs12668156 chr7:2019875 G/A cg20295408 chr7:1910781 MAD1L1 -0.44 -5.96 -0.31 6.37e-9 Bipolar disorder and schizophrenia; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg16275967 chr1:161172255 NDUFS2 0.47 6.16 0.32 2.17e-9 Thyroid stimulating hormone; CRC cis rs12188164 0.965 rs72717438 chr5:448663 C/T cg17553881 chr5:443987 EXOC3;C5orf55 -0.37 -7.81 -0.4 7.64e-14 Cystic fibrosis severity; CRC trans rs1455244 0.700 rs7229302 chr18:11508904 G/T cg21703068 chr21:35015322 ITSN1;CRYZL1 0.4 6.44 0.33 4.19e-10 Schizophrenia; CRC trans rs7395662 1.000 rs12361812 chr11:48563104 A/G cg21153622 chr11:89784906 NA -0.44 -7.11 -0.36 7.07e-12 HDL cholesterol; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg23132254 chr6:18264719 DEK 0.45 6.31 0.33 8.99e-10 Anxiety disorder; CRC trans rs13090388 1 rs13090388 chr3:49391082 C/T cg21582582 chr3:182698605 DCUN1D1 -0.53 -6.62 -0.34 1.45e-10 Intelligence (multi-trait analysis);Educational attainment (years of education); CRC cis rs911119 0.866 rs6048920 chr20:23576844 A/G cg16589663 chr20:23618590 CST3 0.43 6.28 0.33 1.05e-9 Chronic kidney disease; CRC cis rs881375 0.933 rs4837799 chr9:123668326 T/C cg09586646 chr9:123605570 PSMD5;LOC253039 0.53 7.15 0.37 5.49e-12 Rheumatoid arthritis; CRC cis rs531930 0.563 rs332607 chr6:124723354 C/T cg22366943 chr6:124882293 NKAIN2 0.41 6.27 0.33 1.11e-9 Celiac disease; CRC cis rs2306032 0.669 rs10838622 chr11:46856536 T/C cg19486271 chr11:47235900 DDB2 -0.47 -7.76 -0.39 1.08e-13 Total body bone mineral density; CRC cis rs2235544 0.664 rs12036530 chr1:54476323 T/C cg25741118 chr1:54482237 LDLRAD1 -0.21 -5.83 -0.31 1.29e-8 Multiple myeloma (hyperdiploidy);Thyroid hormone levels; CRC cis rs1670533 0.932 rs10902753 chr4:1056223 G/A cg27284194 chr4:1044797 NA 0.51 6.48 0.34 3.41e-10 Recombination rate (females); CRC cis rs10870270 1.000 rs9971066 chr10:133788233 G/A cg17892150 chr10:133769511 PPP2R2D -0.75 -11.13 -0.52 1.21e-24 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; CRC trans rs5756813 0.754 rs34848977 chr22:38165587 G/A cg19894588 chr14:64061835 NA -0.59 -8.02 -0.4 1.91e-14 Optic cup area;Vertical cup-disc ratio; CRC trans rs3733585 0.746 rs4318650 chr4:10016868 T/C cg26043149 chr18:55253948 FECH 0.5 7.46 0.38 7.59e-13 Cleft plate (environmental tobacco smoke interaction); CRC cis rs1997103 1.000 rs2009441 chr7:55405989 A/G cg17469321 chr7:55412551 NA 0.73 11.43 0.53 1.02e-25 QRS interval (sulfonylurea treatment interaction); CRC cis rs4474465 0.915 rs10128737 chr11:78186687 G/A cg27205649 chr11:78285834 NARS2 -0.48 -5.77 -0.3 1.85e-8 Alzheimer's disease (survival time); CRC cis rs7552404 1.000 rs1498312 chr1:76177849 C/T cg03433033 chr1:76189801 ACADM 0.82 11.18 0.52 8.48e-25 Blood metabolite levels;Acylcarnitine levels; CRC cis rs2404602 1.000 rs12594541 chr15:76834368 G/A cg22467129 chr15:76604101 ETFA -0.41 -6.93 -0.36 2.2e-11 Blood metabolite levels; CRC cis rs9768139 0.733 rs921617 chr7:158118198 A/G cg24154853 chr7:158122151 PTPRN2 0.64 10.59 0.5 9.21e-23 Calcium levels; CRC cis rs947211 0.950 rs1775145 chr1:205756143 C/A cg14893161 chr1:205819251 PM20D1 0.46 6.39 0.33 5.68e-10 Parkinson's disease; CRC cis rs2295359 0.892 rs11209005 chr1:67618678 A/G cg03340356 chr1:67600835 NA 0.3 6.86 0.35 3.5e-11 Psoriasis; CRC cis rs826838 0.967 rs826856 chr12:39115434 G/A cg26384229 chr12:38710491 ALG10B -0.61 -9.36 -0.46 1.28e-18 Heart rate; CRC cis rs72627509 0.904 rs7687767 chr4:57824932 C/T cg26694713 chr4:57773883 REST -0.49 -5.89 -0.31 9.32e-9 Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); CRC cis rs7258465 0.965 rs748609 chr19:18560282 T/C cg01065977 chr19:18549689 ISYNA1 -0.41 -6.36 -0.33 6.82e-10 Breast cancer; CRC cis rs12586317 0.514 rs61100068 chr14:35400232 A/T cg05294307 chr14:35346193 BAZ1A -0.69 -7.48 -0.38 6.74e-13 Psoriasis; CRC cis rs7811142 0.830 rs3087502 chr7:99955364 G/A cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.15 16.85 0.68 2.34e-46 Platelet count; CRC cis rs7129727 1 rs7129727 chr11:57484660 G/A cg23127183 chr11:57508653 C11orf31 -0.53 -7.43 -0.38 9.4e-13 Autism spectrum disorder or schizophrenia; CRC cis rs10504229 0.679 rs1442125 chr8:58036258 A/C cg02290350 chr8:58132656 NA 0.4 5.69 0.3 2.85e-8 Developmental language disorder (linguistic errors); CRC cis rs314370 1.000 rs10278546 chr7:100516003 G/T cg10426581 chr7:100472382 SRRT -0.5 -6.39 -0.33 5.63e-10 Resting heart rate; CRC cis rs425277 0.606 rs377283 chr1:2075570 T/C cg21194808 chr1:2205498 SKI 0.4 5.98 0.31 5.73e-9 Height; CRC cis rs6570726 0.967 rs413880 chr6:145804822 G/A cg23711669 chr6:146136114 FBXO30 0.63 10.64 0.51 6.52e-23 Lobe attachment (rater-scored or self-reported); CRC cis rs7224685 0.501 rs2054038 chr17:4014391 A/C cg09597638 chr17:3907349 NA 0.56 9.53 0.47 3.59e-19 Type 2 diabetes; CRC cis rs3736485 0.903 rs750162 chr15:51907153 A/C cg08986416 chr15:51914746 DMXL2 -0.46 -6.44 -0.33 4.34e-10 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs7550918 1 rs7550918 chr1:247675559 C/T cg18198730 chr1:247681584 NA -0.59 -10.43 -0.5 3.47e-22 Platelet count; CRC trans rs916888 0.773 rs199443 chr17:44819565 C/T cg23590916 chr17:43697445 MGC57346 0.7 7.25 0.37 2.9e-12 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs4728142 0.604 rs4731536 chr7:128640293 C/T cg06630958 chr7:128577819 IRF5 -0.34 -5.62 -0.3 4.04e-8 Inflammatory bowel disease;Systemic lupus erythematosus;Ulcerative colitis; CRC cis rs8177179 0.967 rs4994582 chr3:133437566 G/C cg17775713 chr3:133465469 TF 0.35 6.23 0.32 1.41e-9 Iron status biomarkers (transferrin levels); CRC cis rs523522 0.962 rs7488320 chr12:120981630 G/T cg12219531 chr12:120966889 COQ5 0.69 9.3 0.46 2.03e-18 High light scatter reticulocyte count; CRC cis rs1862618 0.529 rs978406 chr5:56259808 A/T cg03609598 chr5:56110824 MAP3K1 0.68 8.12 0.41 9.19e-15 Initial pursuit acceleration; CRC cis rs7613875 0.600 rs1138536 chr3:50153356 C/T cg05623727 chr3:50126028 RBM5 0.62 10.62 0.51 7.28e-23 Body mass index; CRC trans rs2055729 0.677 rs592420 chr8:9760420 A/G cg08975724 chr8:8085496 FLJ10661 0.48 6.14 0.32 2.43e-9 Multiple myeloma (hyperdiploidy); CRC cis rs3096299 0.582 rs12935119 chr16:89542874 A/T cg01788221 chr16:89496183 ANKRD11 -0.38 -5.63 -0.3 3.78e-8 Multiple myeloma (IgH translocation); CRC cis rs10751667 0.643 rs10902238 chr11:944810 G/A cg01483505 chr11:975446 AP2A2 0.42 6.71 0.35 8.38e-11 Alzheimer's disease (late onset); CRC trans rs1656966 1.000 rs1656966 chr3:186466252 C/T cg23891596 chr19:50169132 IRF3;BCL2L12 0.41 6.1 0.32 2.95e-9 Myopia (pathological); CRC cis rs3862030 0.694 rs2025712 chr10:104230064 T/C cg11453585 chr10:104263688 ACTR1A;SUFU -0.76 -13.31 -0.59 1.26e-32 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for body mass index; CRC cis rs6504622 0.545 rs10853087 chr17:45006112 C/G cg16759221 chr17:45003025 GOSR2 0.55 8.77 0.44 9.77e-17 Orofacial clefts; CRC cis rs9807841 0.568 rs1560707 chr19:10750738 A/C cg17710535 chr19:10819994 QTRT1 0.42 5.86 0.31 1.13e-8 Inflammatory skin disease; CRC trans rs3733585 0.699 rs7437120 chr4:9967683 T/A cg26043149 chr18:55253948 FECH -0.49 -7.51 -0.38 5.74e-13 Cleft plate (environmental tobacco smoke interaction); CRC cis rs910316 0.967 rs175479 chr14:75561871 A/C cg08847533 chr14:75593920 NEK9 -0.89 -16.62 -0.68 1.92e-45 Height; CRC cis rs9487051 0.502 rs9386781 chr6:109584520 G/A cg01475377 chr6:109611718 NA -0.35 -6.01 -0.31 5.03e-9 Reticulocyte fraction of red cells; CRC cis rs10979 0.597 rs9496685 chr6:143908690 G/A cg25407410 chr6:143891975 LOC285740 -0.66 -8.82 -0.44 6.76e-17 Hypospadias; CRC cis rs3858526 0.584 rs10769266 chr11:5858460 C/T cg13902645 chr11:5959945 NA -0.66 -9.3 -0.46 2.04e-18 DNA methylation (variation); CRC cis rs875971 1.000 rs1544549 chr7:66090663 T/A cg11764359 chr7:65958608 NA -0.62 -9.61 -0.47 1.99e-19 Aortic root size; CRC cis rs6089584 0.528 rs4925334 chr20:60626769 C/T cg23262073 chr20:60523788 NA -0.42 -6.63 -0.34 1.38e-10 Body mass index; CRC cis rs45544231 0.544 rs9926163 chr16:52565641 G/T cg09051775 chr16:52580266 TOX3 -0.4 -6.52 -0.34 2.6200000000000003e-10 Restless legs syndrome; CRC cis rs1218582 0.741 rs2335407 chr1:154843347 A/G cg24250549 chr1:154909240 PMVK -0.56 -9.27 -0.46 2.49e-18 Prostate cancer; CRC cis rs28374715 0.562 rs8036686 chr15:41550333 C/T cg18705301 chr15:41695430 NDUFAF1 -0.51 -8.48 -0.42 7.63e-16 Ulcerative colitis; CRC cis rs35110281 0.600 rs11089092 chr21:45120994 A/C cg21573476 chr21:45109991 RRP1B -0.39 -5.76 -0.3 1.94e-8 Mean corpuscular volume; CRC cis rs6582630 0.502 rs1589390 chr12:38416139 C/T cg26384229 chr12:38710491 ALG10B -0.52 -7.39 -0.38 1.25e-12 Drug-induced liver injury (flucloxacillin); CRC cis rs10512697 0.655 rs34299253 chr5:3510569 T/C cg19473799 chr5:3511975 NA -0.83 -6.34 -0.33 7.66e-10 Immune response to smallpox vaccine (IL-6); CRC cis rs7914558 0.752 rs7896519 chr10:104866863 C/T cg15744005 chr10:104629667 AS3MT -0.39 -7.97 -0.4 2.69e-14 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs10256972 0.786 rs3735686 chr7:1062527 G/A cg16145915 chr7:1198662 ZFAND2A -0.31 -5.94 -0.31 7.16e-9 Longevity;Endometriosis; CRC cis rs2658782 1.000 rs2658779 chr11:93163137 G/T cg15737290 chr11:93063684 CCDC67 -0.48 -7.23 -0.37 3.45e-12 Pulmonary function decline; CRC cis rs4713118 0.662 rs464312 chr6:27967591 T/A cg15786705 chr6:28176104 NA 0.64 9.23 0.45 3.27e-18 Parkinson's disease; CRC cis rs4975616 0.869 rs370348 chr5:1331219 A/G cg06550200 chr5:1325588 CLPTM1L -0.74 -12.05 -0.55 6.13e-28 Lung cancer; CRC cis rs9372498 0.536 rs77435770 chr6:118819467 G/A cg10217327 chr6:118973057 C6orf204 0.51 5.78 0.3 1.73e-8 Diastolic blood pressure; CRC cis rs3806843 1.000 rs2240695 chr5:140168151 G/T cg19875535 chr5:140030758 IK 0.6 9.78 0.47 5.3e-20 Depressive symptoms (multi-trait analysis); CRC cis rs7208859 0.673 rs9899349 chr17:29200122 C/T cg14008862 chr17:28927542 LRRC37B2 0.55 5.74 0.3 2.12e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs728616 0.867 rs12413715 chr10:81687360 G/T cg11900509 chr10:81946545 ANXA11 -0.63 -6.57 -0.34 2.03e-10 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs2032447 0.610 rs189911 chr6:25965942 A/G cg03517284 chr6:25882590 NA -0.55 -7.6 -0.39 3.12e-13 Intelligence (multi-trait analysis); CRC cis rs6570726 0.577 rs403345 chr6:145845171 T/C cg23711669 chr6:146136114 FBXO30 0.62 9.19 0.45 4.62e-18 Lobe attachment (rater-scored or self-reported); CRC cis rs6951245 1.000 rs11766526 chr7:1101433 G/A cg21664854 chr7:1097933 C7orf50;GPR146 0.77 8.8 0.44 7.85e-17 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC trans rs7395662 0.534 rs12418219 chr11:48988091 G/T cg15704280 chr7:45808275 SEPT13 -0.52 -7.46 -0.38 7.67e-13 HDL cholesterol; CRC cis rs1153858 0.943 rs11070454 chr15:45680252 C/T cg21132104 chr15:45694354 SPATA5L1 0.59 8.51 0.42 6.4e-16 Homoarginine levels; CRC cis rs561341 1.000 rs4795668 chr17:30244554 G/A cg23018236 chr17:30244563 NA -0.64 -7.88 -0.4 4.72e-14 Hip circumference adjusted for BMI; CRC cis rs7937682 0.889 rs484013 chr11:111495779 G/A cg19812747 chr11:111475976 SIK2 -0.59 -10.16 -0.49 2.86e-21 Primary sclerosing cholangitis; CRC trans rs9467711 0.659 rs35277236 chr6:26562269 G/T cg06606381 chr12:133084897 FBRSL1 -1.07 -7.41 -0.38 1.09e-12 Autism spectrum disorder or schizophrenia; CRC cis rs728616 0.681 rs35420115 chr10:81908188 A/G cg05935833 chr10:81318306 SFTPA2 -0.54 -6.22 -0.32 1.5e-9 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs10256972 0.521 rs7811577 chr7:1102829 C/G cg18402987 chr7:1209562 NA 0.44 6.79 0.35 5.14e-11 Longevity;Endometriosis; CRC cis rs9916302 0.851 rs4390625 chr17:37620347 A/G cg03013999 chr17:37608204 MED1 0.45 6.87 0.35 3.15e-11 Glomerular filtration rate (creatinine); CRC cis rs11758351 1.000 rs80259160 chr6:26190199 C/T cg22723502 chr6:26240528 HIST1H4F -0.37 -5.78 -0.3 1.74e-8 Gout;Renal underexcretion gout; CRC cis rs7937682 0.961 rs11601674 chr11:111634354 C/T cg09085632 chr11:111637200 PPP2R1B -1.05 -20.98 -0.76 1.25e-62 Primary sclerosing cholangitis; CRC cis rs73591976 0.540 rs55757502 chr16:68228427 C/T cg08314208 chr16:67682810 RLTPR -0.55 -6.04 -0.32 4.2e-9 HDL cholesterol; CRC trans rs1455244 0.700 rs7229302 chr18:11508904 G/T cg14947789 chr14:55738283 FBXO34 0.41 6.44 0.33 4.24e-10 Schizophrenia; CRC cis rs4523957 0.579 rs903162 chr17:2092200 C/T cg16513277 chr17:2031491 SMG6 -0.57 -10.02 -0.48 8.77e-21 Autism spectrum disorder or schizophrenia;Schizophrenia; CRC cis rs798554 0.797 rs798487 chr7:2802943 G/A cg19717773 chr7:2847554 GNA12 -0.44 -6.13 -0.32 2.52e-9 Height; CRC cis rs8077889 0.956 rs55768269 chr17:41888997 C/T cg16892393 chr17:41919603 NA 0.55 7.7 0.39 1.6e-13 Triglycerides; CRC cis rs4478858 0.684 rs2050816 chr1:31721708 G/T cg00250761 chr1:31883323 NA -0.45 -8.81 -0.44 7.3e-17 Alcohol dependence; CRC cis rs6502050 0.799 rs7501461 chr17:80109806 C/T cg25804541 chr17:80189381 SLC16A3 -0.31 -5.97 -0.31 6.08e-9 Life satisfaction; CRC cis rs3018066 0.867 rs3113249 chr4:107239130 G/T cg01869342 chr4:106983673 TBCK 0.36 5.62 0.3 4.1e-8 Cancer; CRC cis rs2243480 1.000 rs10807701 chr7:65724686 C/A cg25985355 chr7:65971099 NA 0.51 5.77 0.3 1.81e-8 Diabetic kidney disease; CRC cis rs9522267 0.535 rs9522298 chr13:112234457 C/A cg26182253 chr13:112236782 NA 0.31 6.3 0.33 9.74e-10 Hepatitis; CRC cis rs3741151 0.773 rs7931767 chr11:73239207 A/G cg17517138 chr11:73019481 ARHGEF17 0.98 8.0 0.4 2.12e-14 GIP levels in response to oral glucose tolerance test (120 minutes); CRC cis rs6460942 0.915 rs10488158 chr7:12508894 C/T cg20607287 chr7:12443886 VWDE -0.63 -6.27 -0.33 1.14e-9 Coronary artery disease; CRC cis rs12024301 0.557 rs11804300 chr1:183654557 A/G cg11505048 chr1:183622726 RGL1;APOBEC4 0.71 6.24 0.33 1.33e-9 Peripheral arterial disease (traffic-related air pollution interaction); CRC trans rs61931739 0.500 rs9705909 chr12:34576419 G/C cg26384229 chr12:38710491 ALG10B 0.67 8.7 0.43 1.61e-16 Morning vs. evening chronotype; CRC cis rs6502050 0.799 rs6416859 chr17:80111442 G/C cg19223190 chr17:80058835 NA 0.4 6.36 0.33 6.88e-10 Life satisfaction; CRC cis rs6460942 0.915 rs80345607 chr7:12442249 T/C cg20607287 chr7:12443886 VWDE -0.69 -7.29 -0.37 2.4e-12 Coronary artery disease; CRC cis rs9296092 0.538 rs56199698 chr6:33534505 G/C cg13560919 chr6:33536144 NA -0.43 -5.95 -0.31 6.74e-9 Age at smoking initiation in chronic obstructive pulmonary disease; CRC trans rs4586057 0.767 rs11186352 chr10:92651794 G/C cg26894278 chr13:21016241 CRYL1 0.39 6.44 0.33 4.13e-10 Economic and political preferences (time); CRC cis rs6582630 0.519 rs11519914 chr12:38287014 A/G cg26384229 chr12:38710491 ALG10B 0.68 10.03 0.48 7.75e-21 Drug-induced liver injury (flucloxacillin); CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg01524091 chr6:44281032 AARS2 0.4 6.25 0.33 1.28e-9 Obesity-related traits; CRC cis rs728616 0.571 rs113030473 chr10:81649031 G/T cg11900509 chr10:81946545 ANXA11 -0.68 -6.61 -0.34 1.53e-10 Chronic obstructive pulmonary disease-related biomarkers; CRC trans rs6011368 0.607 rs6062363 chr20:62912463 C/T cg13869341 chr1:15865 WASH5P 0.43 6.83 0.35 4.15e-11 Clozapine-induced cytotoxicity; CRC trans rs1656966 1.000 rs1656966 chr3:186466252 C/T cg12771053 chr1:155145617 TRIM46;KRTCAP2 0.42 6.27 0.33 1.12e-9 Myopia (pathological); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg27173322 chr11:61584112 MIR1908;FADS1 0.35 6.46 0.34 3.7e-10 Liver disease severity in Alagille syndrome; CRC cis rs9368481 0.729 rs10946881 chr6:26914611 C/T cg12292205 chr6:26970375 C6orf41 0.67 10.94 0.52 5.68e-24 Autism spectrum disorder or schizophrenia; CRC cis rs1018836 0.923 rs2187982 chr8:91556317 G/T cg16814680 chr8:91681699 NA -0.76 -13.19 -0.59 3.51e-32 Ejection fraction in Tripanosoma cruzi seropositivity; CRC cis rs10791323 0.593 rs11223599 chr11:133717902 A/T cg03690763 chr11:133734501 NA 0.34 5.69 0.3 2.86e-8 Childhood ear infection; CRC cis rs8044868 0.548 rs12930702 chr16:72077000 C/G cg23815491 chr16:72088622 HP 0.47 6.58 0.34 1.85e-10 Body mass index (change over time) in cancer or chronic obstructive pulmonary disease;Body mass index (change over time) in cancer; CRC cis rs7618915 0.501 rs3852066 chr3:52621839 C/T cg18099408 chr3:52552593 STAB1 -0.48 -8.1 -0.41 1.06e-14 Bipolar disorder; CRC cis rs7927771 0.965 rs3817335 chr11:47643891 T/A cg05585544 chr11:47624801 NA -0.59 -10.89 -0.51 8.44e-24 Subjective well-being; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg09491787 chr5:139781927 ANKHD1;ANKHD1-EIF4EBP3 0.5 7.0 0.36 1.43e-11 Response to antipsychotic treatment; CRC cis rs9926296 0.568 rs886950 chr16:89836872 T/C cg21285383 chr16:89894308 SPIRE2 0.36 6.05 0.32 4.04e-9 Vitiligo; CRC cis rs116095464 0.558 rs1971229 chr5:268187 A/G cg22496380 chr5:211416 CCDC127 -0.91 -10.53 -0.5 1.54e-22 Breast cancer; CRC cis rs860295 0.702 rs2175391 chr1:155625602 G/T cg02153340 chr1:155202674 NA 0.53 7.13 0.37 6.36e-12 Body mass index; CRC cis rs911555 0.519 rs8014069 chr14:104004311 A/C cg24130564 chr14:104152367 KLC1 -0.45 -5.93 -0.31 7.66e-9 Intelligence (multi-trait analysis); CRC cis rs6500602 0.929 rs6500603 chr16:4497537 G/C cg14951292 chr16:4525986 HMOX2;NMRAL1 0.58 8.55 0.43 4.74e-16 Schizophrenia; CRC cis rs4917833 0.764 rs1925645 chr10:100220472 T/C cg19043522 chr10:100227446 HPSE2 0.37 5.61 0.3 4.21e-8 Pediatric bone mineral density (femoral neck); CRC cis rs11628318 0.570 rs4906231 chr14:103062227 T/C cg23071808 chr14:103021642 NA -0.64 -7.19 -0.37 4.38e-12 Platelet count; CRC cis rs9911578 0.967 rs6416932 chr17:57148991 G/A cg12560992 chr17:57184187 TRIM37 0.93 17.58 0.7 3.07e-49 Intelligence (multi-trait analysis); CRC cis rs7542091 0.739 rs10863793 chr1:210037420 G/A cg05527609 chr1:210001259 C1orf107 -0.45 -5.81 -0.31 1.47e-8 Monobrow; CRC cis rs4969178 0.600 rs2376583 chr17:76402105 A/T cg05887092 chr17:76393375 PGS1 0.62 12.29 0.56 7.75e-29 HDL cholesterol levels; CRC cis rs4750440 0.706 rs11258767 chr10:14016565 C/T cg00551146 chr10:14014579 FRMD4A 0.37 6.04 0.32 4.25e-9 Adiponectin levels; CRC cis rs4594175 0.926 rs10145287 chr14:51626808 G/T cg23942311 chr14:51606299 NA 0.61 9.84 0.48 3.46e-20 Cancer; CRC cis rs17345786 1.000 rs3804778 chr3:101294572 C/T cg11279151 chr3:101281821 RG9MTD1 -0.68 -8.22 -0.41 4.66e-15 Colonoscopy-negative controls vs population controls; CRC cis rs2310173 0.651 rs11689480 chr2:102674501 G/A cg20856504 chr2:102616538 IL1R2 0.35 5.75 0.3 2.01e-8 Ankylosing spondylitis;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined);Ulcerative colitis; CRC cis rs9931543 0.504 rs9922112 chr16:56314687 A/C cg02433656 chr16:56322654 GNAO1 0.48 7.2 0.37 3.99e-12 Subjective well-being; CRC cis rs2732480 0.577 rs2634678 chr12:48735538 C/G cg21466736 chr12:48725269 NA -0.61 -9.06 -0.45 1.18e-17 Hemoglobin concentration;Red blood cell count;Hematocrit; CRC cis rs9457247 0.508 rs6918286 chr6:167505829 C/T cg07513332 chr6:167530253 CCR6 0.35 6.33 0.33 7.98e-10 Crohn's disease; CRC cis rs7727544 0.735 rs274568 chr5:131713578 C/T cg11843238 chr5:131593191 PDLIM4 -0.31 -5.69 -0.3 2.86e-8 Blood metabolite levels; CRC cis rs2840044 0.963 rs225247 chr17:33944590 T/A cg05299278 chr17:33885742 SLFN14 0.4 5.97 0.31 6.23e-9 Response to radiotherapy in cancer (late toxicity); CRC cis rs9486719 1.000 rs2179126 chr6:96871350 A/G cg06623918 chr6:96969491 KIAA0776 0.81 9.51 0.46 4.17e-19 Migraine;Coronary artery disease; CRC cis rs853679 0.517 rs9283884 chr6:28135660 C/G cg06470822 chr6:28175283 NA -1.02 -13.36 -0.59 8e-33 Depression; CRC cis rs7811142 1.000 rs7783159 chr7:100017454 C/T cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.59 7.24 0.37 3.11e-12 Platelet count; CRC cis rs116095464 0.558 rs62347677 chr5:227453 A/G cg22496380 chr5:211416 CCDC127 -0.87 -10.06 -0.49 6.01e-21 Breast cancer; CRC cis rs9491140 0.539 rs2208814 chr6:124692555 G/A cg22366943 chr6:124882293 NKAIN2 0.57 8.09 0.41 1.19e-14 Neuroticism; CRC cis rs2795502 0.564 rs11239840 chr10:43439353 C/T cg08461752 chr10:43522343 NA -0.63 -5.9 -0.31 9.27e-9 Blood protein levels; CRC cis rs6831352 0.918 rs17817359 chr4:100054197 G/T cg13256891 chr4:100009986 ADH5 -0.66 -8.89 -0.44 4.04e-17 Alcohol dependence; CRC cis rs2882667 0.898 rs6862393 chr5:138364698 T/C cg09476006 chr5:138032270 NA 0.44 7.47 0.38 7.39e-13 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs6815814 0.861 rs10012017 chr4:38784633 G/T cg06935464 chr4:38784597 TLR10 0.69 9.03 0.45 1.49e-17 Breast cancer; CRC cis rs2230307 0.536 rs522696 chr1:100476662 G/A cg24955406 chr1:100503596 HIAT1 0.58 7.0 0.36 1.45e-11 Carotid intima media thickness; CRC cis rs9611565 0.592 rs9611613 chr22:41961831 T/C cg06634786 chr22:41940651 POLR3H -0.52 -6.07 -0.32 3.46e-9 Vitiligo; CRC cis rs6696846 0.749 rs6692170 chr1:205074019 G/A cg00857998 chr1:205179979 DSTYK 0.41 5.86 0.31 1.11e-8 Red blood cell count; CRC cis rs7186908 0.761 rs34714490 chr16:72177099 G/T cg23815491 chr16:72088622 HP 0.64 8.12 0.41 9.28e-15 Liver enzyme levels (alkaline phosphatase); CRC cis rs12497850 0.864 rs4279134 chr3:49156676 A/G cg07636037 chr3:49044803 WDR6 0.96 15.81 0.66 2.7e-42 Parkinson's disease; CRC cis rs7208859 0.623 rs9911997 chr17:29124648 A/G cg01831904 chr17:28903510 LRRC37B2 -0.62 -6.41 -0.33 5.13e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs294883 0.826 rs9355264 chr6:159700955 C/T cg14500486 chr6:159655392 FNDC1 -0.35 -5.75 -0.3 2.09e-8 Coronary artery disease; CRC cis rs9640161 0.750 rs3735173 chr7:150020526 C/T cg13722127 chr7:150037890 RARRES2 0.48 7.83 0.4 6.64e-14 Blood protein levels;Circulating chemerin levels; CRC cis rs896854 0.875 rs4735333 chr8:95955074 G/A cg09323728 chr8:95962352 TP53INP1 -0.42 -6.98 -0.36 1.68e-11 Type 2 diabetes; CRC cis rs17401966 0.838 rs11121551 chr1:10435170 T/C cg19773385 chr1:10388646 KIF1B -0.66 -10.8 -0.51 1.81e-23 Hepatocellular carcinoma; CRC cis rs7402982 0.625 rs4966009 chr15:99203496 C/T cg03437748 chr15:99193247 IGF1R 0.55 7.4 0.38 1.17e-12 Birth weight; CRC cis rs12148488 0.966 rs1867149 chr15:75339993 C/T cg18612461 chr15:75251733 NA -0.38 -5.82 -0.31 1.41e-8 Caffeine consumption; CRC cis rs6951245 0.572 rs112072378 chr7:1039400 C/T cg20603222 chr7:1096387 C7orf50;GPR146 -0.74 -6.03 -0.32 4.32e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC trans rs9914544 0.545 rs7222748 chr17:18787976 T/C cg21372672 chr17:16614065 CCDC144A -0.39 -6.1 -0.32 2.93e-9 Educational attainment (years of education); CRC cis rs427394 0.593 rs880993 chr5:6732120 C/G cg15145174 chr5:6755386 POLS -0.46 -6.8 -0.35 5e-11 Menopause (age at onset); CRC cis rs7804356 1.000 rs7802715 chr7:26852720 C/A cg03456212 chr7:26904342 SKAP2 -0.52 -5.68 -0.3 2.98e-8 Type 1 diabetes; CRC cis rs9787249 0.957 rs10888958 chr1:40211737 T/C cg24920358 chr1:40204285 PPIE 0.57 8.68 0.43 1.81e-16 Blood protein levels; CRC cis rs10504229 0.775 rs17804840 chr8:58157045 C/T cg05313129 chr8:58192883 C8orf71 -0.48 -6.25 -0.33 1.29e-9 Developmental language disorder (linguistic errors); CRC cis rs2070488 0.861 rs1858740 chr3:38438372 T/C cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.88 15.62 0.65 1.56e-41 Electrocardiographic conduction measures; CRC cis rs10193935 1.000 rs10195776 chr2:42425098 G/A cg27598129 chr2:42591480 NA -0.72 -8.11 -0.41 9.89e-15 Colonoscopy-negative controls vs population controls; CRC cis rs11098499 0.644 rs3806808 chr4:120551085 A/C cg24375607 chr4:120327624 NA 0.49 7.56 0.38 3.93e-13 Corneal astigmatism; CRC cis rs7618915 0.547 rs4687636 chr3:52633929 G/A cg07507251 chr3:52567010 NT5DC2 0.45 6.51 0.34 2.8e-10 Bipolar disorder; CRC cis rs13108904 0.905 rs1732108 chr4:1276550 C/T cg20887711 chr4:1340912 KIAA1530 -0.45 -6.38 -0.33 6.1e-10 Obesity-related traits; CRC cis rs6693567 0.565 rs834237 chr1:150363930 A/G cg15654264 chr1:150340011 RPRD2 0.43 6.52 0.34 2.68e-10 Migraine; CRC cis rs79349575 0.783 rs12453394 chr17:46994970 G/A cg22482690 chr17:47019901 SNF8 0.48 8.01 0.4 2.05e-14 Type 2 diabetes; CRC cis rs595982 0.559 rs17272680 chr19:49364511 A/G cg15549821 chr19:49342101 PLEKHA4 0.55 6.63 0.34 1.34e-10 Red cell distribution width; CRC cis rs2985684 0.947 rs1952013 chr14:50087357 C/G cg10008539 chr14:50087325 RPL36AL;MGAT2 -0.45 -6.05 -0.32 3.99e-9 Carotid intima media thickness; CRC cis rs79839061 0.518 rs3755961 chr4:895059 A/G cg14530993 chr4:882597 GAK 0.8 7.59 0.39 3.35e-13 Intelligence (multi-trait analysis); CRC cis rs7786808 0.741 rs11767875 chr7:158228923 A/G cg09998033 chr7:158218633 PTPRN2 -0.63 -9.06 -0.45 1.21e-17 Obesity-related traits; CRC cis rs798554 0.757 rs1182179 chr7:2873648 A/G cg19717773 chr7:2847554 GNA12 -0.5 -7.22 -0.37 3.73e-12 Height; CRC cis rs972578 0.837 rs7364152 chr22:43316667 A/G cg01576275 chr22:43409880 NA -0.37 -5.73 -0.3 2.3e-8 Mean platelet volume; CRC cis rs9916302 0.800 rs11869259 chr17:37518141 C/A cg00129232 chr17:37814104 STARD3 0.53 7.86 0.4 5.7e-14 Glomerular filtration rate (creatinine); CRC cis rs801193 0.844 rs7779971 chr7:66161790 T/C cg05627663 chr7:65219948 SNORA22;CCT6P1 0.43 6.27 0.33 1.13e-9 Aortic root size; CRC cis rs734999 0.545 rs10797436 chr1:2538349 G/A cg18854424 chr1:2615690 NA 0.4 7.57 0.39 3.73e-13 Ulcerative colitis; CRC cis rs854765 0.547 rs4368210 chr17:17896090 A/G cg16928487 chr17:17741425 SREBF1 0.49 8.3 0.42 2.65e-15 Total body bone mineral density; CRC cis rs4654899 0.758 rs7530739 chr1:21447480 C/A cg02927042 chr1:21476669 EIF4G3 -0.41 -6.58 -0.34 1.86e-10 Superior frontal gyrus grey matter volume; CRC cis rs2535633 0.631 rs2465101 chr3:52991307 A/T cg11645453 chr3:52864694 ITIH4 -0.42 -7.73 -0.39 1.34e-13 Body mass index; CRC cis rs1799949 1.000 rs8176318 chr17:41197274 G/T cg19454999 chr17:41278357 BRCA1;NBR2 0.47 7.44 0.38 8.93e-13 Menopause (age at onset); CRC trans rs10050311 0.685 rs7678571 chr4:87754713 C/T cg02563553 chr3:135913687 MSL2 0.51 6.37 0.33 6.46e-10 Insulin-related traits; CRC cis rs72615157 0.561 rs113844570 chr7:99873778 A/C cg00814883 chr7:100076585 TSC22D4 -0.51 -5.82 -0.31 1.38e-8 Lung function (FEV1/FVC); CRC cis rs4285028 0.696 rs3915060 chr3:121712980 C/T cg11130432 chr3:121712080 ILDR1 0.53 6.94 0.36 2.1e-11 Multiple sclerosis; CRC cis rs1552244 0.872 rs115331527 chr3:10154504 G/A cg13047869 chr3:10149882 C3orf24 0.59 7.95 0.4 3.01e-14 Alzheimer's disease; CRC cis rs6952808 0.929 rs12532128 chr7:1925454 T/C cg20295408 chr7:1910781 MAD1L1 -0.43 -6.14 -0.32 2.43e-9 Bipolar disorder and schizophrenia; CRC cis rs7809950 1.000 rs10234355 chr7:107086517 T/G cg23024343 chr7:107201750 COG5 -0.61 -8.71 -0.43 1.54e-16 Coronary artery disease; CRC cis rs9467711 0.790 rs10484439 chr6:26309908 G/A cg16898833 chr6:26189333 HIST1H4D 0.99 7.54 0.38 4.65e-13 Autism spectrum disorder or schizophrenia; CRC cis rs11758351 0.660 rs2143345 chr6:26229148 C/T cg01420254 chr6:26195488 NA 0.72 7.97 0.4 2.58e-14 Gout;Renal underexcretion gout; CRC cis rs7224737 1.000 rs9912088 chr17:40288278 T/C cg00647820 chr17:40259828 DHX58 -0.46 -6.56 -0.34 2.12e-10 Fibrinogen levels; CRC cis rs7927771 0.864 rs4752838 chr11:47466006 G/A cg18512352 chr11:47633146 NA -0.41 -7.91 -0.4 3.94e-14 Subjective well-being; CRC cis rs3815700 0.920 rs10424732 chr19:33096487 C/T cg02997394 chr19:33096574 ANKRD27 0.8 9.29 0.46 2.2e-18 Eosinophilic esophagitis; CRC cis rs2380220 0.574 rs9400526 chr6:95998441 T/C cg04719120 chr6:96025338 MANEA 0.52 6.43 0.33 4.56e-10 Behavioural disinhibition (generation interaction); CRC cis rs2303759 0.918 rs8107548 chr19:49870643 T/C cg24324837 chr19:49891574 CCDC155 0.62 8.74 0.43 1.23e-16 Multiple sclerosis; CRC cis rs12477438 0.765 rs2278895 chr2:99613484 G/A cg14399236 chr2:99771627 LIPT1;TSGA10 -0.6 -8.19 -0.41 6.03e-15 Chronic sinus infection; CRC cis rs4073416 0.510 rs10873190 chr14:65981439 G/T cg03016385 chr14:66212404 NA -0.42 -5.93 -0.31 7.71e-9 N-glycan levels; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg04832844 chr4:26321136 RBPJ 0.4 6.34 0.33 7.6e-10 Intelligence (multi-trait analysis); CRC trans rs12478296 1.000 rs12469535 chr2:243044147 G/A cg06834434 chr14:75079333 LTBP2 0.55 6.48 0.34 3.33e-10 Obesity-related traits; CRC cis rs10484885 0.775 rs62416027 chr6:90608054 C/G cg13799429 chr6:90582589 CASP8AP2 -0.71 -7.8 -0.39 8.44e-14 QRS interval (sulfonylurea treatment interaction); CRC trans rs2727020 0.658 rs7111215 chr11:49430552 T/C cg11707556 chr5:10655725 ANKRD33B -0.39 -7.31 -0.37 1.99e-12 Coronary artery disease; CRC cis rs713587 0.713 rs11125884 chr2:25239264 C/T cg22495460 chr2:25135724 ADCY3 -0.66 -11.3 -0.53 3.04e-25 Body mass index in non-asthmatics; CRC trans rs453301 0.686 rs6748 chr8:8890802 C/T cg16141378 chr3:129829833 LOC729375 0.4 6.13 0.32 2.57e-9 Joint mobility (Beighton score); CRC trans rs6601327 0.607 rs6992666 chr8:9586704 A/C cg06636001 chr8:8085503 FLJ10661 -0.5 -7.37 -0.38 1.35e-12 Multiple myeloma (hyperdiploidy); CRC cis rs853679 0.517 rs9393887 chr6:28059020 G/A cg12172441 chr6:28176163 NA 0.61 7.27 0.37 2.7e-12 Depression; CRC cis rs4698036 0.586 rs7672759 chr4:10285015 G/A cg11266682 chr4:10021025 SLC2A9 0.33 5.92 0.31 7.92e-9 Cardiovascular disease risk factors; CRC cis rs9292777 0.666 rs5026793 chr5:40436612 C/T cg09067459 chr5:40385259 NA -0.53 -8.63 -0.43 2.76e-16 Crohn's disease;Multiple sclerosis; CRC cis rs1048238 0.525 rs848214 chr1:16265422 A/G cg21385522 chr1:16154831 NA -0.62 -9.03 -0.45 1.43e-17 Systolic blood pressure; CRC cis rs2204008 0.774 rs12810027 chr12:38212165 A/G cg13010199 chr12:38710504 ALG10B 0.45 5.74 0.3 2.1e-8 Bladder cancer; CRC cis rs305851 0.846 rs2651317 chr6:39767137 A/G cg02386599 chr6:39769542 DAAM2 0.37 5.81 0.3 1.49e-8 Lobe attachment (rater-scored or self-reported); CRC cis rs7833986 1.000 rs34952804 chr8:57097399 T/C cg23139584 chr8:56987506 RPS20;SNORD54 0.61 7.54 0.38 4.64e-13 Height; CRC cis rs968567 0.817 rs61896141 chr11:61556039 A/C cg23760165 chr11:61595485 FADS2 -0.47 -6.32 -0.33 8.47e-10 Blood metabolite levels;Rheumatoid arthritis;Vitiligo;Glycerophospholipid levels; CRC cis rs10504229 0.683 rs35244711 chr8:58117762 T/G cg24829409 chr8:58192753 C8orf71 -0.55 -8.03 -0.4 1.71e-14 Developmental language disorder (linguistic errors); CRC cis rs9494145 0.652 rs9399137 chr6:135419018 T/C cg22676075 chr6:135203613 NA 0.57 7.19 0.37 4.42e-12 Mean platelet volume;Platelet count;Fetal hemoglobin levels in sickle cell anemia;Red blood cell traits; CRC cis rs7727544 0.584 rs7714191 chr5:131341541 C/G cg11843238 chr5:131593191 PDLIM4 0.35 6.39 0.33 5.83e-10 Blood metabolite levels; CRC cis rs6570726 0.967 rs7772286 chr6:145930423 A/T cg13319975 chr6:146136371 FBXO30 0.41 6.13 0.32 2.53e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs1552244 0.938 rs66915020 chr3:10110174 A/G cg00166722 chr3:10149974 C3orf24 0.66 9.02 0.45 1.59e-17 Alzheimer's disease; CRC cis rs28386778 0.865 rs2727276 chr17:61929709 G/A cg06873352 chr17:61820015 STRADA 0.73 13.62 0.6 8.27e-34 Prudent dietary pattern; CRC cis rs1862618 0.853 rs860580 chr5:56149429 G/T cg24531977 chr5:56204891 C5orf35 0.79 10.7 0.51 4.12e-23 Initial pursuit acceleration; CRC cis rs6662572 0.578 rs6662306 chr1:46287286 G/A cg03123370 chr1:45965343 CCDC163P;MMACHC 0.46 5.87 0.31 1.04e-8 Blood protein levels; CRC trans rs1997103 1.000 rs6973337 chr7:55411534 T/C cg20935933 chr6:143382018 AIG1 0.51 6.63 0.34 1.35e-10 QRS interval (sulfonylurea treatment interaction); CRC cis rs2404602 0.692 rs72738889 chr15:76992063 G/A cg22467129 chr15:76604101 ETFA -0.41 -6.87 -0.35 3.16e-11 Blood metabolite levels; CRC cis rs7615952 0.599 rs6766327 chr3:125723677 C/G cg02772935 chr3:125709198 NA -0.52 -6.11 -0.32 2.89e-9 Blood pressure (smoking interaction); CRC cis rs9303280 0.617 rs6503525 chr17:38095174 C/G cg26162295 chr17:38119207 GSDMA 0.31 5.63 0.3 3.76e-8 Self-reported allergy; CRC cis rs11122272 0.670 rs2474632 chr1:231484361 C/T cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.55 -8.23 -0.41 4.57e-15 Hemoglobin concentration; CRC cis rs9463078 0.764 rs9395051 chr6:44825715 C/A cg25276700 chr6:44698697 NA -0.26 -6.33 -0.33 7.82e-10 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; CRC trans rs61931739 0.500 rs7298322 chr12:34445489 A/T cg13010199 chr12:38710504 ALG10B 0.46 6.52 0.34 2.6200000000000003e-10 Morning vs. evening chronotype; CRC trans rs561341 0.505 rs28708703 chr17:30386845 C/G cg27661571 chr11:113659931 NA -0.69 -8.79 -0.44 8.72e-17 Hip circumference adjusted for BMI; CRC cis rs4076764 0.958 rs12022261 chr1:163398422 A/G cg06092702 chr1:163392909 NA -0.61 -9.62 -0.47 1.84e-19 Motion sickness; CRC cis rs4319547 0.656 rs28730465 chr12:122863864 A/C cg23029597 chr12:123009494 RSRC2 0.59 7.21 0.37 3.98e-12 Body mass index; CRC cis rs17608059 0.504 rs11656981 chr17:13978777 A/G cg27005118 chr17:13972210 COX10 -0.42 -9.5 -0.46 4.45e-19 Temperament; CRC cis rs35264875 0.846 rs72930627 chr11:68867121 C/A cg01993067 chr11:68851601 TPCN2 0.53 5.93 0.31 7.58e-9 Blond vs. brown hair color; CRC cis rs769267 0.930 rs4808957 chr19:19567248 A/G cg01262667 chr19:19385393 TM6SF2 0.36 5.92 0.31 7.96e-9 Tonsillectomy; CRC cis rs736408 0.511 rs12637632 chr3:52708073 A/T cg18099408 chr3:52552593 STAB1 -0.46 -7.55 -0.38 4.2e-13 Bipolar disorder; CRC cis rs35110281 0.591 rs230642 chr21:44915533 A/C cg01579765 chr21:45077557 HSF2BP 0.35 6.44 0.33 4.16e-10 Mean corpuscular volume; CRC cis rs7586879 0.521 rs7597332 chr2:25075675 A/G cg04586622 chr2:25135609 ADCY3 -0.48 -8.59 -0.43 3.62e-16 Body mass index; CRC cis rs4443100 0.670 rs9612225 chr22:23406619 G/A cg14186256 chr22:23484241 RTDR1 0.46 5.9 0.31 8.93e-9 Serum parathyroid hormone levels; CRC cis rs8060686 0.920 rs73591961 chr16:67801309 G/A cg19582491 chr16:67682965 RLTPR -0.57 -6.53 -0.34 2.56e-10 HDL cholesterol;Metabolic syndrome; CRC cis rs394563 0.559 rs7752555 chr6:149671116 A/G cg03678062 chr6:149772716 ZC3H12D 0.34 6.18 0.32 1.9e-9 Dupuytren's disease; CRC cis rs6942756 0.806 rs68184415 chr7:128988862 C/T cg02491457 chr7:128862824 NA -0.63 -8.68 -0.43 1.8e-16 White matter hyperintensity burden; CRC cis rs801193 0.569 rs2013908 chr7:66121069 A/T cg11764359 chr7:65958608 NA -0.59 -8.69 -0.43 1.7e-16 Aortic root size; CRC trans rs4263408 0.934 rs9683743 chr4:39703194 A/C cg20786939 chr1:226374532 ACBD3 -0.41 -5.98 -0.31 5.7e-9 Plasma amyloid beta peptide concentrations (ABx-40); CRC cis rs875971 0.522 rs709604 chr7:65497434 A/G cg00343986 chr7:65444356 GUSB -0.58 -8.71 -0.43 1.52e-16 Aortic root size; CRC trans rs11654801 0.755 rs11658791 chr17:20881698 G/A cg23759823 chr7:139672531 TBXAS1 -0.41 -6.12 -0.32 2.64e-9 Mosquito bite size; CRC cis rs11123170 0.543 rs12472361 chr2:113980645 C/G cg11763394 chr2:113992921 PAX8;LOC440839;LOC654433 0.5 5.82 0.31 1.39e-8 Renal function-related traits (BUN); CRC cis rs1577917 0.629 rs6927475 chr6:86206773 G/A cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A 0.49 6.9 0.36 2.61e-11 Response to antipsychotic treatment; CRC cis rs2832191 1.000 rs8131214 chr21:30483386 T/G cg24692254 chr21:30365293 RNF160 -0.64 -10.91 -0.52 7.13e-24 Dental caries; CRC cis rs1862618 0.853 rs33322 chr5:56175226 A/G cg22800045 chr5:56110881 MAP3K1 0.62 6.64 0.34 1.29e-10 Initial pursuit acceleration; CRC cis rs13108904 0.870 rs13124876 chr4:1247955 T/C cg05665937 chr4:1216051 CTBP1 0.43 6.58 0.34 1.87e-10 Obesity-related traits; CRC cis rs17021463 0.902 rs36099342 chr4:95239783 T/C cg11021082 chr4:95130006 SMARCAD1 0.46 6.71 0.35 8.28e-11 Testicular germ cell tumor; CRC cis rs1218582 0.772 rs4845690 chr1:154886817 C/T cg09359103 chr1:154839909 KCNN3 0.71 12.96 0.58 2.68e-31 Prostate cancer; CRC cis rs1949733 1.000 rs6837429 chr4:8502374 A/G cg13073564 chr4:8508604 NA -0.49 -7.33 -0.37 1.85e-12 Response to antineoplastic agents; CRC cis rs735539 1.000 rs6490605 chr13:21285009 C/T cg04906043 chr13:21280425 IL17D -0.5 -8.06 -0.41 1.38e-14 Dental caries; CRC cis rs9905704 0.918 rs35934668 chr17:56894638 A/G cg12560992 chr17:57184187 TRIM37 0.53 7.22 0.37 3.69e-12 Testicular germ cell tumor; CRC cis rs941873 0.868 rs7332 chr10:81114060 G/A cg09469691 chr10:81107165 PPIF 0.58 9.38 0.46 1.12e-18 Height; CRC cis rs1983170 1.000 rs483532 chr1:91980447 A/G cg21854759 chr1:92012499 NA -0.51 -6.51 -0.34 2.82e-10 Eosinophil percentage of white cells; CRC cis rs10504229 0.593 rs12155520 chr8:58014318 C/T cg08219700 chr8:58056026 NA 0.55 6.5 0.34 2.99e-10 Developmental language disorder (linguistic errors); CRC cis rs4665809 0.590 rs62128455 chr2:26466530 G/A cg25036284 chr2:26402008 FAM59B 0.61 7.76 0.39 1.09e-13 Gut microbiome composition (summer); CRC cis rs2456568 0.867 rs2462750 chr11:93668590 C/T cg26875233 chr11:93583750 C11orf90 -0.33 -6.52 -0.34 2.65e-10 Response to serotonin reuptake inhibitors in major depressive disorder; CRC cis rs8177253 0.530 rs8177177 chr3:133463195 A/G cg01448562 chr3:133502909 NA -0.4 -6.58 -0.34 1.9e-10 Iron status biomarkers; CRC cis rs4728302 0.869 rs6962865 chr7:133599433 T/A cg10665199 chr7:133106180 EXOC4 0.38 5.77 0.3 1.8e-8 Intelligence;Intelligence (multi-trait analysis); CRC cis rs7412746 0.634 rs12562939 chr1:150951452 A/C cg10589385 chr1:150898437 SETDB1 0.32 6.54 0.34 2.4e-10 Melanoma; CRC cis rs136211 0.929 rs1883273 chr22:36769685 A/G cg16924664 chr22:36878180 TXN2 -0.4 -5.9 -0.31 9.17e-9 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs8078723 1.000 rs7214085 chr17:38169095 T/C cg17467752 chr17:38218738 THRA 0.73 12.02 0.55 8e-28 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); CRC cis rs2579519 0.547 rs2463560 chr2:96595589 T/C cg23100626 chr2:96804247 ASTL 0.25 6.92 0.36 2.31e-11 Diastolic blood pressure; CRC cis rs654950 0.841 rs2810549 chr1:41991761 C/T cg06885757 chr1:42089581 HIVEP3 -0.35 -6.01 -0.31 4.85e-9 Airway imaging phenotypes; CRC cis rs73198271 0.562 rs964773 chr8:8651314 T/C cg01851573 chr8:8652454 MFHAS1 0.54 7.0 0.36 1.48e-11 Bone ultrasound measurement (broadband ultrasound attenuation); CRC cis rs6461049 0.800 rs3778977 chr7:2159746 C/T cg02951883 chr7:2050386 MAD1L1 -0.58 -9.3 -0.46 2.01e-18 Schizophrenia; CRC cis rs11585357 0.501 rs72646770 chr1:17580767 T/C cg08277548 chr1:17600880 PADI3 -0.66 -7.69 -0.39 1.69e-13 Hair shape; CRC cis rs9467773 0.596 rs3001369 chr6:26670969 C/T cg09904177 chr6:26538194 HMGN4 0.69 10.75 0.51 2.66e-23 Intelligence (multi-trait analysis); CRC cis rs4665809 0.567 rs12999875 chr2:26414847 A/C cg08067268 chr2:26466485 HADHB;HADHA 0.67 8.53 0.43 5.3e-16 Gut microbiome composition (summer); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg01972394 chr1:19229528 ALDH4A1 0.42 6.27 0.33 1.15e-9 Intelligence (multi-trait analysis); CRC cis rs17376456 0.877 rs13185660 chr5:93336500 G/A cg25358565 chr5:93447407 FAM172A 1.07 10.71 0.51 3.56e-23 Diabetic retinopathy; CRC cis rs453301 0.686 rs7017868 chr8:8873293 G/A cg06636001 chr8:8085503 FLJ10661 -0.5 -7.43 -0.38 9.66e-13 Joint mobility (Beighton score); CRC cis rs7312933 0.865 rs1920687 chr12:42398275 T/C cg01256987 chr12:42539512 GXYLT1 -0.4 -6.05 -0.32 3.85e-9 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CRC cis rs2836974 0.739 rs12482181 chr21:40548852 A/G cg11890956 chr21:40555474 PSMG1 1.08 18.2 0.71 1.07e-51 Cognitive function; CRC cis rs9381040 0.610 rs2057002 chr6:41022962 G/T cg03644281 chr6:41068752 NFYA;LOC221442 -0.45 -6.45 -0.34 4.01e-10 Alzheimer's disease (late onset); CRC cis rs6502050 0.835 rs4789665 chr17:80168097 A/C cg13198984 chr17:80129470 CCDC57 0.42 7.24 0.37 3.1e-12 Life satisfaction; CRC cis rs13256369 0.951 rs13259955 chr8:8565885 C/G cg17143192 chr8:8559678 CLDN23 0.51 6.7 0.35 8.79e-11 Obesity-related traits; CRC cis rs4132509 1.000 rs10927051 chr1:243805936 G/C cg21452805 chr1:244014465 NA 0.5 6.76 0.35 6.12e-11 RR interval (heart rate); CRC cis rs2976388 0.647 rs2585154 chr8:143783485 C/T cg15511327 chr8:143859410 LYNX1 0.39 6.82 0.35 4.39e-11 Urinary tract infection frequency; CRC cis rs6121246 0.542 rs2376990 chr20:30238744 G/A cg18721089 chr20:30220636 NA -0.41 -6.65 -0.34 1.21e-10 Mean corpuscular hemoglobin; CRC cis rs11098499 0.909 rs11098530 chr4:120413154 C/T cg24375607 chr4:120327624 NA 0.49 7.5 0.38 6.06e-13 Corneal astigmatism; CRC cis rs12200560 0.505 rs211174 chr6:97071120 C/T cg06623918 chr6:96969491 KIAA0776 0.49 7.08 0.36 8.64e-12 Coronary heart disease; CRC cis rs10504229 1.000 rs61733801 chr8:58192513 A/G cg01721255 chr8:58191610 C8orf71 0.49 6.17 0.32 2e-9 Developmental language disorder (linguistic errors); CRC cis rs17270561 0.636 rs7453371 chr6:25719256 A/G cg16482183 chr6:26056742 HIST1H1C 0.74 9.47 0.46 5.46e-19 Iron status biomarkers; CRC cis rs10504229 0.679 rs75402323 chr8:58136227 A/G cg21724239 chr8:58056113 NA 0.49 6.81 0.35 4.75e-11 Developmental language disorder (linguistic errors); CRC cis rs10504229 0.817 rs78138632 chr8:58191341 G/T cg02725872 chr8:58115012 NA -0.54 -7.07 -0.36 9.5e-12 Developmental language disorder (linguistic errors); CRC cis rs1697139 0.583 rs11739727 chr5:66540940 G/A cg11553311 chr5:66541588 NA 0.57 9.62 0.47 1.88e-19 Breast cancer; CRC cis rs6120849 0.901 rs6058193 chr20:33734464 A/G cg24642439 chr20:33292090 TP53INP2 0.44 5.72 0.3 2.34e-8 Protein C levels; CRC cis rs2795502 1.000 rs2795502 chr10:43340662 G/A cg27426351 chr10:43362370 NA -0.6 -7.08 -0.36 8.62e-12 Blood protein levels; CRC trans rs637571 0.544 rs617791 chr11:65702523 C/G cg17712092 chr4:129076599 LARP1B 0.65 11.1 0.52 1.51e-24 Eosinophil percentage of white cells; CRC cis rs826838 0.967 rs34496261 chr12:39023829 G/A cg26384229 chr12:38710491 ALG10B 0.73 10.18 0.49 2.52e-21 Heart rate; CRC cis rs10751667 0.643 rs7395613 chr11:933873 C/T cg01483505 chr11:975446 AP2A2 0.43 6.82 0.35 4.37e-11 Alzheimer's disease (late onset); CRC cis rs11711311 0.955 rs9830102 chr3:113408302 C/A cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.48 -6.41 -0.33 4.94e-10 IgG glycosylation; CRC cis rs9929218 0.817 rs3114402 chr16:68719607 C/T cg02972257 chr16:68554789 NA 0.51 6.38 0.33 5.95e-10 Colorectal cancer; CRC cis rs9911578 1.000 rs1494977 chr17:56863064 C/T cg05425664 chr17:57184151 TRIM37 -0.47 -7.33 -0.37 1.76e-12 Intelligence (multi-trait analysis); CRC cis rs11864453 1.000 rs11864453 chr16:72050480 C/T cg23815491 chr16:72088622 HP 0.59 9.27 0.46 2.47e-18 Fibrinogen levels; CRC cis rs10256972 0.568 rs1133043 chr7:1133305 C/G cg27094323 chr7:1216898 NA -0.37 -6.09 -0.32 3.08e-9 Longevity;Endometriosis; CRC cis rs2243480 1.000 rs422164 chr7:65586605 C/G cg18252515 chr7:66147081 NA -1.2 -14.32 -0.62 1.67e-36 Diabetic kidney disease; CRC cis rs2694528 0.686 rs6864253 chr5:59862743 A/G cg11474532 chr5:59995715 DEPDC1B 0.64 5.76 0.3 1.96e-8 Parkinson's disease; CRC cis rs853679 0.517 rs7755442 chr6:28039015 T/C cg12273811 chr6:28175739 NA 0.69 8.81 0.44 7.29e-17 Depression; CRC cis rs4523957 0.583 rs9907384 chr17:2045375 A/C cg16513277 chr17:2031491 SMG6 -0.62 -10.6 -0.5 8.53e-23 Autism spectrum disorder or schizophrenia;Schizophrenia; CRC trans rs61931739 0.517 rs1817760 chr12:34106060 A/G cg26384229 chr12:38710491 ALG10B 0.53 6.78 0.35 5.71e-11 Morning vs. evening chronotype; CRC cis rs2463822 1.000 rs2463821 chr11:62111662 T/C cg06239285 chr11:62104954 ASRGL1 1.03 11.07 0.52 2.03e-24 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs3820068 0.581 rs58567918 chr1:15925823 A/G cg24675056 chr1:15929824 NA 0.49 6.66 0.34 1.12e-10 Systolic blood pressure; CRC cis rs7412746 0.658 rs2089082 chr1:150800090 T/G cg17724175 chr1:150552817 MCL1 0.49 7.31 0.37 2.03e-12 Melanoma; CRC cis rs4973397 0.601 rs2034412 chr2:232288061 C/G cg13347044 chr2:232276743 NA -0.4 -5.91 -0.31 8.41e-9 Anti-saccade response; CRC cis rs8177253 0.931 rs8177256 chr3:133480276 G/T cg08048268 chr3:133502702 NA -0.36 -6.81 -0.35 4.74e-11 Iron status biomarkers; CRC cis rs28493229 0.708 rs73546845 chr19:41158717 C/T cg21869046 chr19:41225005 ITPKC 0.42 6.39 0.33 5.78e-10 Kawasaki disease; CRC cis rs853679 0.607 rs33932084 chr6:28268824 A/G cg12185399 chr6:27640341 NA 0.8 5.86 0.31 1.11e-8 Depression; CRC cis rs853679 0.517 rs9357063 chr6:28060005 G/A cg03623178 chr6:28175578 NA 0.95 12.39 0.56 3.47e-29 Depression; CRC cis rs910187 0.678 rs6018330 chr20:45813216 C/T cg27589058 chr20:45804311 EYA2 -0.39 -7.38 -0.38 1.29e-12 Migraine; CRC cis rs4862750 0.872 rs1991254 chr4:187875375 T/G cg11301795 chr4:187892539 NA -0.86 -18.4 -0.71 1.68e-52 Lobe attachment (rater-scored or self-reported); CRC cis rs9905704 0.918 rs34430710 chr17:56876627 A/T cg12560992 chr17:57184187 TRIM37 0.5 6.83 0.35 4.04e-11 Testicular germ cell tumor; CRC cis rs6694672 1.000 rs1412631 chr1:197037237 C/T cg13682187 chr1:196946512 CFHR5 -0.41 -6.87 -0.35 3.25e-11 Asthma; CRC cis rs9513593 1.000 rs1927724 chr13:99992312 A/C cg21788972 chr13:99853209 UBAC2 0.46 5.97 0.31 6.29e-9 Psoriasis; CRC cis rs847577 0.609 rs11763970 chr7:97817321 A/G cg00277769 chr7:97922759 BAIAP2L1 -0.41 -6.81 -0.35 4.63e-11 Breast cancer; CRC cis rs8067545 0.611 rs10491107 chr17:20188174 C/T cg13482628 chr17:19912719 NA 0.5 7.98 0.4 2.41e-14 Schizophrenia; CRC trans rs10982213 0.830 rs2274163 chr9:117188714 C/T cg08135327 chr2:134877962 NA 0.39 6.28 0.33 1.06e-9 Interleukin-6 levels; CRC cis rs7487075 1.000 rs12827740 chr12:46848115 T/A cg22049899 chr12:47219821 SLC38A4 0.31 6.16 0.32 2.12e-9 Itch intensity from mosquito bite; CRC cis rs6570726 1.000 rs1935615 chr6:145921117 G/T cg05347473 chr6:146136440 FBXO30 0.4 6.06 0.32 3.71e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs6426558 0.537 rs6692080 chr1:227390162 C/T cg10327440 chr1:227177885 CDC42BPA -0.44 -6.52 -0.34 2.63e-10 Neutrophil percentage of white cells; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg26004255 chr14:24584161 DCAF11 0.47 6.39 0.33 5.82e-10 Anxiety disorder; CRC cis rs7659604 0.539 rs3217771 chr4:122739483 G/A cg19748678 chr4:122722346 EXOSC9 0.65 10.31 0.49 8.54e-22 Type 2 diabetes; CRC trans rs360798 0.532 rs11125942 chr2:62966758 T/C cg05376469 chr2:102649931 NA 0.38 6.04 0.32 4.2e-9 Coronary artery disease; CRC cis rs1348850 0.914 rs10194648 chr2:178337031 G/A cg22681709 chr2:178499509 PDE11A -0.4 -7.24 -0.37 3.14e-12 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs6681460 0.898 rs2483704 chr1:67195353 C/T cg02459107 chr1:67143332 SGIP1 -0.37 -6.3 -0.33 9.3e-10 Presence of antiphospholipid antibodies; CRC cis rs4746818 0.793 rs2008553 chr10:70860475 C/G cg11621586 chr10:70884670 VPS26A 0.53 5.89 0.31 9.72e-9 Left atrial antero-posterior diameter; CRC cis rs12325245 0.536 rs71375919 chr16:58547522 C/T cg01472538 chr16:58549086 SETD6 1.1 7.19 0.37 4.4e-12 Schizophrenia; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg18604133 chr13:27746144 USP12 0.46 6.47 0.34 3.62e-10 Anxiety disorder; CRC cis rs7666738 0.830 rs10005173 chr4:98816062 T/C cg05340658 chr4:99064831 C4orf37 0.53 7.67 0.39 1.99e-13 Colonoscopy-negative controls vs population controls; CRC cis rs375066 0.935 rs10414702 chr19:44380536 A/G cg12072164 chr19:44306565 LYPD5 0.37 5.61 0.3 4.36e-8 Breast cancer; CRC trans rs12699921 0.566 rs2723515 chr7:17855466 A/G cg15753394 chr6:17282781 RBM24 -0.36 -6.16 -0.32 2.18e-9 Fibrinogen levels; CRC cis rs9916302 0.784 rs4795382 chr17:37700860 A/G cg00129232 chr17:37814104 STARD3 -0.55 -8.14 -0.41 8.5e-15 Glomerular filtration rate (creatinine); CRC cis rs10946940 0.965 rs62401383 chr6:27564547 C/T cg15845792 chr6:28175446 NA -0.46 -6.25 -0.33 1.24e-9 Systemic lupus erythematosus; CRC cis rs17209837 0.915 rs17149660 chr7:87089524 T/C cg00919237 chr7:87102261 ABCB4 -0.49 -6.03 -0.32 4.4e-9 Gallbladder cancer; CRC cis rs4474465 0.790 rs10793325 chr11:78252575 T/C cg02023728 chr11:77925099 USP35 -0.37 -6.24 -0.33 1.33e-9 Alzheimer's disease (survival time); CRC cis rs4459895 0.762 rs10804914 chr3:187970450 A/G cg17585528 chr3:187988060 LPP -0.56 -6.07 -0.32 3.62e-9 Nodular sclerosis Hodgkin lymphoma;Hodgkin's lymphoma;B-cell malignancies (chronic lymphocytic leukemia, Hodgkin lymphoma or multiple myeloma) (pleiotropy); CRC cis rs10540 1.000 rs61877775 chr11:521462 C/T cg08200582 chr11:442649 ANO9 -0.71 -6.89 -0.36 2.83e-11 Body mass index; CRC cis rs7772486 0.790 rs3924498 chr6:146233338 A/T cg13319975 chr6:146136371 FBXO30 0.43 6.52 0.34 2.66e-10 Lobe attachment (rater-scored or self-reported); CRC cis rs6951245 0.554 rs35126802 chr7:1134842 C/T cg04025307 chr7:1156635 C7orf50 0.67 8.5 0.42 6.7e-16 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs1577917 0.958 rs10944137 chr6:86454314 C/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.61 -7.69 -0.39 1.7e-13 Response to antipsychotic treatment; CRC trans rs6546043 0.559 rs11125986 chr2:64132637 T/C cg20306022 chr2:7947960 NA -0.51 -5.97 -0.31 6.22e-9 Clozapine-induced agranulocytosis; CRC cis rs501120 0.584 rs7100370 chr10:44698508 A/C cg09554077 chr10:44749378 NA 0.67 7.5 0.38 5.94e-13 Coronary artery disease;Coronary heart disease; CRC cis rs12681287 0.640 rs13269259 chr8:87470453 G/A cg27223183 chr8:87520930 FAM82B -0.52 -7.47 -0.38 7.07e-13 Caudate activity during reward; CRC cis rs2739330 0.789 rs5760109 chr22:24252938 C/G cg11905131 chr22:24372483 LOC391322 -0.72 -11.51 -0.54 5.26e-26 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs7811142 1.000 rs11769700 chr7:100090049 T/C cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.93 12.29 0.56 8.1e-29 Platelet count; CRC cis rs4648845 0.777 rs2477686 chr1:2392648 C/G cg13556452 chr1:2391241 NA -0.42 -7.46 -0.38 7.99e-13 Schizophrenia; CRC cis rs9359856 0.564 rs72915903 chr6:90420190 A/C cg13799429 chr6:90582589 CASP8AP2 -0.71 -8.11 -0.41 1.01e-14 Bipolar disorder; CRC cis rs12541635 0.934 rs4734893 chr8:106990275 T/G cg10147462 chr8:107024639 NA 0.43 6.98 0.36 1.61e-11 Age of smoking initiation; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg09379601 chr19:12992224 DNASE2 0.5 6.55 0.34 2.19e-10 Thyroid stimulating hormone; CRC trans rs877282 0.583 rs7072970 chr10:822757 G/A cg22713356 chr15:30763199 NA 0.88 9.65 0.47 1.49e-19 Uric acid levels; CRC cis rs1008375 0.932 rs11941874 chr4:17666416 C/T cg16339924 chr4:17578868 LAP3 -0.52 -6.41 -0.33 5.15e-10 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs4713118 0.868 rs742047 chr6:27739380 A/G cg20933634 chr6:27740509 NA 0.63 7.28 0.37 2.52e-12 Parkinson's disease; CRC cis rs6860806 0.507 rs272892 chr5:131664349 C/T cg04518342 chr5:131593106 PDLIM4 0.42 6.91 0.36 2.54e-11 Breast cancer; CRC cis rs921968 0.565 rs608047 chr2:219615910 A/C cg02176678 chr2:219576539 TTLL4 0.45 7.11 0.37 7.05e-12 Mean corpuscular hemoglobin concentration; CRC cis rs9659323 1.000 rs9659323 chr1:119504361 A/G cg26570165 chr1:119541833 NA -0.38 -6.46 -0.34 3.67e-10 Body mass index; CRC cis rs2949837 0.581 rs1496499 chr7:45979023 T/G cg23193639 chr7:45961078 IGFBP3 0.4 6.64 0.34 1.29e-10 Sitting height ratio; CRC cis rs3126085 0.935 rs2184950 chr1:152272776 T/C cg09127314 chr1:152161683 NA -0.46 -5.81 -0.31 1.46e-8 Atopic dermatitis; CRC cis rs798766 1.000 rs798724 chr4:1704643 C/T cg25714306 chr4:1656736 FAM53A -0.31 -5.62 -0.3 4.03e-8 Bladder cancer;Urinary bladder cancer; CRC trans rs916888 0.773 rs9896243 chr17:44826056 C/G cg10053473 chr17:62856997 LRRC37A3 -0.69 -7.38 -0.38 1.27e-12 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC trans rs2228479 0.850 rs11646766 chr16:89838578 A/T cg24644049 chr4:85504048 CDS1 0.91 7.51 0.38 5.67e-13 Skin colour saturation; CRC cis rs735539 0.914 rs7997065 chr13:21273796 A/G cg27499820 chr13:21296301 IL17D -0.37 -5.97 -0.31 6.25e-9 Dental caries; CRC cis rs2839186 0.900 rs2839196 chr21:47708037 G/A cg13126279 chr21:47581558 C21orf56 -0.52 -8.11 -0.41 1.02e-14 Testicular germ cell tumor; CRC cis rs9916302 0.851 rs11078907 chr17:37662954 C/T cg03013999 chr17:37608204 MED1 0.45 6.92 0.36 2.36e-11 Glomerular filtration rate (creatinine); CRC cis rs3008870 0.755 rs2815349 chr1:67472280 G/A cg08660285 chr1:67390436 MIER1;WDR78 0.54 7.7 0.39 1.62e-13 Lymphocyte percentage of white cells; CRC cis rs2404602 0.692 rs12595586 chr15:77172210 A/G cg23625390 chr15:77176239 SCAPER 0.46 6.53 0.34 2.56e-10 Blood metabolite levels; CRC cis rs9457247 0.765 rs2237276 chr6:167442115 C/T cg07741184 chr6:167504864 NA 0.37 6.52 0.34 2.6e-10 Crohn's disease; CRC cis rs3733585 0.673 rs4292332 chr4:9953830 C/A cg11266682 chr4:10021025 SLC2A9 -0.47 -9.62 -0.47 1.76e-19 Cleft plate (environmental tobacco smoke interaction); CRC cis rs1552244 0.515 rs67342818 chr3:10166406 G/A cg18598329 chr3:10140678 FANCD2;C3orf24 -0.91 -10.81 -0.51 1.62e-23 Alzheimer's disease; CRC cis rs62244186 0.593 rs9814298 chr3:44871899 T/A cg11003573 chr3:44754125 ZNF502 -0.34 -5.81 -0.3 1.49e-8 Depressive symptoms; CRC cis rs9303401 0.538 rs2240259 chr17:56458129 A/C cg02118635 chr17:56770003 RAD51C;TEX14 0.69 8.61 0.43 3.02e-16 Cognitive test performance; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg00497091 chr1:145438415 TXNIP 0.49 6.28 0.33 1.05e-9 Thyroid stimulating hormone; CRC cis rs5753037 0.585 rs249401 chr22:30216168 C/T cg01021169 chr22:30184971 ASCC2 -0.4 -6.21 -0.32 1.61e-9 Type 1 diabetes; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg00654709 chr1:93646505 TMED5;CCDC18 0.43 6.22 0.32 1.54e-9 Intelligence (multi-trait analysis); CRC cis rs2569991 0.541 rs2596905 chr3:12937672 A/C cg22481960 chr3:13008800 IQSEC1 -0.52 -6.47 -0.34 3.45e-10 Periodontitis (DPAL); CRC cis rs1065852 0.526 rs7290907 chr22:42390209 G/A cg00645731 chr22:42541494 CYP2D7P1 0.4 6.85 0.35 3.59e-11 Response to serotonin reuptake inhibitors in major depressive disorder (plasma drug and metabolite levels); CRC cis rs10504229 1.000 rs73607863 chr8:58170178 A/G cg22535103 chr8:58192502 C8orf71 -0.82 -12.27 -0.56 9.63e-29 Developmental language disorder (linguistic errors); CRC cis rs3849570 0.961 rs3849571 chr3:81777716 A/C cg07356753 chr3:81810745 GBE1 -0.74 -11.1 -0.52 1.53e-24 Waist circumference;Body mass index; CRC cis rs477895 0.653 rs34089806 chr11:63887987 C/T cg04317338 chr11:64019027 PLCB3 0.62 7.56 0.38 4.07e-13 Mean platelet volume; CRC cis rs6429082 0.806 rs2382570 chr1:235570523 G/A cg26050004 chr1:235667680 B3GALNT2 -0.4 -5.93 -0.31 7.51e-9 Adiposity; CRC cis rs11098499 0.954 rs4309825 chr4:120314881 C/T cg24375607 chr4:120327624 NA -0.5 -7.57 -0.39 3.84e-13 Corneal astigmatism; CRC cis rs6952808 0.531 rs3778998 chr7:2180753 C/A cg02951883 chr7:2050386 MAD1L1 -0.54 -8.34 -0.42 2.01e-15 Bipolar disorder and schizophrenia; CRC cis rs2303759 0.709 rs10411679 chr19:49826480 A/T cg24324837 chr19:49891574 CCDC155 0.53 7.0 0.36 1.45e-11 Multiple sclerosis; CRC cis rs3741404 0.560 rs17699798 chr11:63898806 C/G cg20160996 chr11:63990575 FERMT3 0.4 6.48 0.34 3.36e-10 Platelet count; CRC cis rs2976388 0.609 rs2244152 chr8:143784885 C/A cg24046110 chr8:143859143 LYNX1 0.49 8.52 0.42 6.03e-16 Urinary tract infection frequency; CRC cis rs4819052 0.851 rs3673 chr21:46681775 C/T cg11663144 chr21:46675770 NA -0.7 -11.31 -0.53 2.72e-25 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs2370759 0.945 rs10508773 chr10:32575444 C/T cg01819863 chr10:32635814 EPC1 1.08 13.14 0.59 5.59e-32 Sexual dysfunction (female); CRC cis rs2228479 1.000 rs11642267 chr16:89957635 T/C cg06558623 chr16:89946397 TCF25 1.08 10.68 0.51 4.63e-23 Skin colour saturation; CRC cis rs6921919 0.638 rs1416920 chr6:28302784 A/G cg03623178 chr6:28175578 NA 0.45 6.0 0.31 5.12e-9 Autism spectrum disorder or schizophrenia; CRC trans rs853679 0.546 rs13214023 chr6:28332141 A/G cg06606381 chr12:133084897 FBRSL1 1.45 11.78 0.54 5.72e-27 Depression; CRC cis rs11577318 0.853 rs7541333 chr1:26622889 C/T cg04990556 chr1:26633338 UBXN11 -0.47 -6.17 -0.32 1.98e-9 Granulocyte percentage of myeloid white cells; CRC cis rs6860806 0.507 rs2631372 chr5:131703578 C/G cg18301423 chr5:131593218 PDLIM4 0.39 6.59 0.34 1.77e-10 Breast cancer; CRC cis rs3858526 0.523 rs10838749 chr11:5884246 A/G cg05234568 chr11:5960015 NA -0.64 -9.05 -0.45 1.32e-17 DNA methylation (variation); CRC cis rs734999 0.566 rs4648658 chr1:2560882 G/A cg20673091 chr1:2541236 MMEL1 -0.37 -5.91 -0.31 8.33e-9 Ulcerative colitis; CRC cis rs875971 0.830 rs6967708 chr7:65657313 A/T cg18876405 chr7:65276391 NA -0.52 -8.74 -0.43 1.22e-16 Aortic root size; CRC cis rs28386778 0.897 rs4968599 chr17:61835992 T/C cg22520471 chr17:61851767 DDX42;CCDC47 0.74 11.57 0.54 3.22e-26 Prudent dietary pattern; CRC cis rs13108904 0.901 rs4493484 chr4:1279944 G/A cg02018176 chr4:1364513 KIAA1530 0.48 7.84 0.4 6.25e-14 Obesity-related traits; CRC trans rs61931739 0.500 rs34418276 chr12:34535976 C/T cg26384229 chr12:38710491 ALG10B 0.66 8.55 0.43 4.71e-16 Morning vs. evening chronotype; CRC cis rs10927875 0.501 rs61782229 chr1:16220118 G/A cg21385522 chr1:16154831 NA -0.84 -9.87 -0.48 2.65e-20 Dilated cardiomyopathy; CRC trans rs11764590 0.671 rs56226325 chr7:2078981 C/T cg11693508 chr17:37793320 STARD3 0.61 7.0 0.36 1.47e-11 Neuroticism; CRC cis rs3617 0.573 rs12638968 chr3:52919447 T/A cg07507251 chr3:52567010 NT5DC2 -0.39 -5.98 -0.31 5.83e-9 Red blood cell count;Autism spectrum disorder or schizophrenia; CRC cis rs4888262 0.526 rs8056718 chr16:74612030 G/C cg01733217 chr16:74700730 RFWD3 0.79 11.94 0.55 1.53e-27 Testicular germ cell tumor; CRC cis rs10256972 0.758 rs7799391 chr7:1082566 C/G cg23708337 chr7:1209742 NA 0.38 5.81 0.31 1.45e-8 Longevity;Endometriosis; CRC cis rs9914988 0.943 rs2242345 chr17:27185827 C/T cg16670446 chr17:27188758 MIR451;MIR144 -0.55 -8.73 -0.43 1.33e-16 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg16026627 chr12:49393027 DDN 0.46 6.3 0.33 9.71e-10 Thyroid stimulating hormone; CRC cis rs6500602 0.727 rs7193136 chr16:4580034 C/T cg08645402 chr16:4508243 NA 0.63 10.91 0.52 7.16e-24 Schizophrenia; CRC cis rs7618915 0.501 rs13060048 chr3:52598608 G/A cg18099408 chr3:52552593 STAB1 -0.48 -8.3 -0.42 2.81e-15 Bipolar disorder; CRC cis rs896854 0.654 rs4735339 chr8:95974373 C/T cg16049864 chr8:95962084 TP53INP1 -0.65 -11.8 -0.55 5.04e-27 Type 2 diabetes; CRC cis rs10504229 0.683 rs77548248 chr8:58117542 G/A cg05313129 chr8:58192883 C8orf71 -0.43 -5.95 -0.31 7.03e-9 Developmental language disorder (linguistic errors); CRC cis rs875971 0.545 rs316323 chr7:65610989 C/T cg02869306 chr7:64672164 INTS4L1 0.44 6.36 0.33 6.89e-10 Aortic root size; CRC cis rs7274811 0.744 rs2071056 chr20:32265513 A/G cg14921437 chr20:32255988 NECAB3;C20orf134 -0.42 -5.77 -0.3 1.79e-8 Height; CRC cis rs6860806 0.695 rs6867282 chr5:131583120 G/C cg22638593 chr5:131593259 PDLIM4 0.41 7.63 0.39 2.52e-13 Breast cancer; CRC cis rs5758511 0.689 rs56906457 chr22:42628335 A/G cg00645731 chr22:42541494 CYP2D7P1 0.66 9.2 0.45 4.27e-18 Birth weight; CRC cis rs1348850 0.540 rs10172355 chr2:178443225 A/G cg27490568 chr2:178487706 NA 0.5 6.33 0.33 8.13e-10 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs13161895 1.000 rs34027780 chr5:179478891 C/A cg02702477 chr5:179499311 RNF130 0.55 6.33 0.33 7.99e-10 LDL cholesterol; CRC cis rs950169 0.579 rs12912716 chr15:84664263 A/T cg17507749 chr15:85114479 UBE2QP1 0.63 8.61 0.43 3.05e-16 Schizophrenia; CRC cis rs11785400 1.000 rs9720653 chr8:143731939 T/G cg24634471 chr8:143751801 JRK 0.54 7.68 0.39 1.81e-13 Schizophrenia; CRC cis rs2067615 0.524 rs10778498 chr12:107063340 C/A cg13491945 chr12:107078410 RFX4 0.35 6.17 0.32 2e-9 Heart rate; CRC cis rs17376456 0.877 rs17315943 chr5:93442830 T/C cg09848695 chr5:92956644 FAM172A;MIR2277 0.63 5.83 0.31 1.29e-8 Diabetic retinopathy; CRC cis rs1800795 0.599 rs1546762 chr7:22757503 C/T cg05472934 chr7:22766657 IL6 0.66 10.41 0.5 3.91e-22 Cerebrospinal fluid clusterin levels in APOEe4- carriers; CRC cis rs4665809 0.590 rs10179959 chr2:26426403 G/A cg25036284 chr2:26402008 FAM59B -0.61 -7.77 -0.39 1.04e-13 Gut microbiome composition (summer); CRC cis rs6952808 0.862 rs4721167 chr7:1933224 C/T cg02951883 chr7:2050386 MAD1L1 -0.7 -11.31 -0.53 2.74e-25 Bipolar disorder and schizophrenia; CRC cis rs7312933 0.702 rs10785333 chr12:42586470 A/G cg19980929 chr12:42632907 YAF2 -0.43 -6.34 -0.33 7.4e-10 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CRC cis rs2204008 0.774 rs11180977 chr12:38263094 G/T cg13010199 chr12:38710504 ALG10B 0.45 5.75 0.3 2.07e-8 Bladder cancer; CRC cis rs6964587 0.626 rs35849169 chr7:91507313 A/G cg17063962 chr7:91808500 NA 0.54 8.62 0.43 2.88e-16 Breast cancer; CRC cis rs13315871 1.000 rs13071688 chr3:58398730 G/A cg20936604 chr3:58311152 NA -0.75 -7.14 -0.37 5.96e-12 Cholesterol, total; CRC cis rs2380220 1.000 rs2380222 chr6:95975395 C/T cg07718321 chr6:96025334 MANEA 0.51 5.98 0.31 5.83e-9 Behavioural disinhibition (generation interaction); CRC cis rs35306767 0.951 rs12777021 chr10:967270 T/C cg26597838 chr10:835615 NA 1.1 13.12 0.59 6.44e-32 Eosinophil percentage of granulocytes; CRC cis rs7107174 1.000 rs2510041 chr11:77945284 G/A cg02023728 chr11:77925099 USP35 0.47 8.01 0.4 2.01e-14 Testicular germ cell tumor; CRC cis rs11690935 0.959 rs10497374 chr2:172640623 A/G cg13550731 chr2:172543902 DYNC1I2 -1.11 -18.97 -0.72 9.74e-55 Schizophrenia; CRC cis rs6502050 0.835 rs4789678 chr17:80101078 C/T cg13198984 chr17:80129470 CCDC57 0.43 7.61 0.39 2.95e-13 Life satisfaction; CRC cis rs4664293 0.867 rs16844269 chr2:160599080 G/A cg08347373 chr2:160653686 CD302 -0.47 -7.43 -0.38 9.32e-13 Monocyte percentage of white cells; CRC cis rs35110281 0.744 rs162398 chr21:44949285 T/C cg01579765 chr21:45077557 HSF2BP -0.37 -6.9 -0.36 2.65e-11 Mean corpuscular volume; CRC cis rs9916302 0.706 rs8073907 chr17:37424149 C/T cg07936489 chr17:37558343 FBXL20 -0.88 -11.05 -0.52 2.3e-24 Glomerular filtration rate (creatinine); CRC cis rs12134245 0.747 rs35654098 chr1:92001452 T/A cg02896835 chr1:92012615 NA -0.65 -11.78 -0.54 6.03e-27 Breast cancer; CRC cis rs67311347 0.956 rs13066971 chr3:40462510 A/T cg24209194 chr3:40518798 ZNF619 -0.44 -6.88 -0.35 3.06e-11 Renal cell carcinoma; CRC cis rs9905704 0.723 rs71372848 chr17:56736598 G/C cg12560992 chr17:57184187 TRIM37 0.56 7.63 0.39 2.5e-13 Testicular germ cell tumor; CRC cis rs6952809 0.561 rs1548598 chr7:2438912 T/C cg23289794 chr7:2394357 EIF3B -0.75 -9.23 -0.45 3.38e-18 Multiple sclerosis; CRC cis rs9488822 0.596 rs6568921 chr6:116373616 C/T cg26893134 chr6:116381904 FRK 0.26 7.12 0.37 6.89e-12 Cholesterol, total;LDL cholesterol; CRC cis rs11229555 0.609 rs12575080 chr11:58224917 A/G cg15696309 chr11:58395628 NA -0.91 -11.54 -0.54 4.09e-26 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; CRC cis rs929354 0.713 rs1034785 chr7:157002383 T/C cg17757837 chr7:157058334 UBE3C 0.75 12.69 0.57 2.65e-30 Body mass index; CRC cis rs2455601 0.786 rs3751064 chr11:8958903 T/C cg21881798 chr11:8931708 C11orf17;ST5 -0.57 -6.59 -0.34 1.76e-10 Schizophrenia; CRC cis rs2836950 0.565 rs7279497 chr21:40531306 A/G cg11890956 chr21:40555474 PSMG1 0.67 10.07 0.49 5.69e-21 Menarche (age at onset); CRC cis rs9462027 0.628 rs10947521 chr6:34689377 G/T cg07306190 chr6:34760872 UHRF1BP1 0.34 6.07 0.32 3.49e-9 Systemic lupus erythematosus; CRC cis rs6582630 0.537 rs1829579 chr12:38420555 A/G cg26384229 chr12:38710491 ALG10B 0.7 9.8 0.48 4.54e-20 Drug-induced liver injury (flucloxacillin); CRC cis rs9399135 0.967 rs10872427 chr6:135353452 T/C cg22676075 chr6:135203613 NA 0.41 6.39 0.33 5.63e-10 Red blood cell count; CRC cis rs832540 0.898 rs252890 chr5:56226410 T/C cg12311346 chr5:56204834 C5orf35 -0.52 -7.97 -0.4 2.68e-14 Coronary artery disease; CRC cis rs4713118 0.955 rs9393847 chr6:27687973 G/A cg21204522 chr6:27730016 NA -0.41 -5.61 -0.3 4.28e-8 Parkinson's disease; CRC cis rs208520 1.000 rs72882079 chr6:66973878 T/C cg07460842 chr6:66804631 NA 0.92 11.38 0.53 1.56e-25 Exhaled nitric oxide output; CRC cis rs853679 0.546 rs200490 chr6:27796935 G/T cg15845792 chr6:28175446 NA 0.73 6.45 0.34 3.9e-10 Depression; CRC cis rs4713118 0.662 rs9468275 chr6:28026136 G/T cg12172441 chr6:28176163 NA 0.55 6.96 0.36 1.83e-11 Parkinson's disease; CRC trans rs561341 0.739 rs1978116 chr17:30220978 A/C cg20587970 chr11:113659929 NA -0.66 -8.61 -0.43 3.17e-16 Hip circumference adjusted for BMI; CRC cis rs17666538 0.539 rs1703925 chr8:608279 A/G cg23958373 chr8:599963 NA 0.84 7.67 0.39 1.91e-13 IgG glycosylation; CRC cis rs11690935 0.632 rs62183783 chr2:172865775 A/G cg13550731 chr2:172543902 DYNC1I2 0.65 9.46 0.46 6.22e-19 Schizophrenia; CRC cis rs8077889 1.000 rs113919636 chr17:41877740 A/C cg25876840 chr17:41920477 NA 0.53 7.42 0.38 1e-12 Triglycerides; CRC cis rs853679 0.517 rs9380047 chr6:28037893 G/T cg12963246 chr6:28129442 ZNF389 0.48 5.7 0.3 2.72e-8 Depression; CRC cis rs11785400 1.000 rs10099892 chr8:143734608 C/T cg24634471 chr8:143751801 JRK 0.53 7.57 0.38 3.91e-13 Schizophrenia; CRC cis rs2976388 0.590 rs7828042 chr8:143819383 A/G cg05569086 chr8:143859399 LYNX1 -0.39 -6.43 -0.33 4.45e-10 Urinary tract infection frequency; CRC cis rs2153535 0.580 rs2327050 chr6:8440630 A/G cg21535247 chr6:8435926 SLC35B3 0.48 7.24 0.37 3.19e-12 Motion sickness; CRC cis rs7127900 0.614 rs72853920 chr11:2206429 T/C cg10838469 chr11:2211741 NA -0.47 -6.62 -0.34 1.45e-10 Prostate cancer;Prostate cancer (SNP x SNP interaction);Prostate cancer (early onset); CRC cis rs9584850 0.708 rs4411372 chr13:99130423 T/C cg20487152 chr13:99095054 FARP1 0.39 5.6 0.3 4.44e-8 Neuroticism; CRC cis rs7666738 0.830 rs17027090 chr4:98897923 G/T cg05340658 chr4:99064831 C4orf37 0.57 8.57 0.43 4.13e-16 Colonoscopy-negative controls vs population controls; CRC cis rs7412746 0.611 rs12410869 chr1:150856153 G/T cg10589385 chr1:150898437 SETDB1 0.28 5.94 0.31 7.44e-9 Melanoma; CRC cis rs7412746 0.634 rs4451553 chr1:150937329 C/T cg18016565 chr1:150552671 MCL1 0.43 6.11 0.32 2.87e-9 Melanoma; CRC cis rs977987 0.806 rs6564252 chr16:75388940 C/T cg03315344 chr16:75512273 CHST6 0.52 8.74 0.43 1.22e-16 Dupuytren's disease; CRC trans rs2270927 0.510 rs6453213 chr5:75579518 A/G cg13563193 chr19:33072644 PDCD5 0.73 7.06 0.36 1e-11 Mean corpuscular volume; CRC cis rs6752107 0.935 rs11688431 chr2:234147175 T/C cg07618928 chr2:234183455 ATG16L1;SCARNA5 0.56 8.85 0.44 5.66e-17 Crohn's disease;Inflammatory bowel disease; CRC cis rs7618501 0.602 rs2526743 chr3:50115245 G/A cg05623727 chr3:50126028 RBM5 -0.44 -7.47 -0.38 7.28e-13 Intelligence (multi-trait analysis); CRC cis rs7937682 0.961 rs17113227 chr11:111620491 A/G cg19812747 chr11:111475976 SIK2 -0.48 -7.57 -0.38 3.89e-13 Primary sclerosing cholangitis; CRC cis rs9916302 0.904 rs620686 chr17:37453617 A/G cg07936489 chr17:37558343 FBXL20 0.82 12.72 0.57 2.08e-30 Glomerular filtration rate (creatinine); CRC cis rs6838801 0.964 rs7686697 chr4:77570354 T/A cg17476223 chr4:77663285 SHROOM3 0.41 5.61 0.3 4.2e-8 Cleft lip with or without cleft palate; CRC cis rs79839061 0.610 rs12651271 chr4:854071 C/T cg14530993 chr4:882597 GAK 0.82 7.87 0.4 5.02e-14 Intelligence (multi-trait analysis); CRC cis rs1577917 0.771 rs6454486 chr6:86433587 C/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A 0.6 8.47 0.42 8.24e-16 Response to antipsychotic treatment; CRC cis rs6479527 0.840 rs1331217 chr9:96766510 A/C cg14459158 chr9:96720562 NA 0.41 7.4 0.38 1.16e-12 Esophageal adenocarcinoma; CRC cis rs12594515 1.000 rs8027000 chr15:45987795 T/C cg22117107 chr15:45993392 NA -0.44 -9.09 -0.45 9.56e-18 Waist circumference;Weight; CRC cis rs11212617 0.967 rs227066 chr11:108209199 C/T cg01991180 chr11:108092276 ATM;NPAT 0.4 5.75 0.3 2.06e-8 Response to metformin in type 2 diabetes (glycemic); CRC cis rs9733 0.596 rs34140753 chr1:150642583 T/C cg18016565 chr1:150552671 MCL1 0.46 6.74 0.35 6.91e-11 Tonsillectomy; CRC cis rs2882667 0.898 rs2882792 chr5:138380480 G/T cg09476006 chr5:138032270 NA 0.44 7.44 0.38 8.91e-13 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs7762018 0.941 rs4716387 chr6:170136777 G/C cg19338460 chr6:170058176 WDR27 -0.72 -7.88 -0.4 4.8e-14 Thiazide-induced adverse metabolic effects in hypertensive patients; CRC cis rs6951245 1.000 rs28399710 chr7:1070631 G/T cg20603222 chr7:1096387 C7orf50;GPR146 -0.69 -8.1 -0.41 1.07e-14 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC trans rs9545047 0.680 rs9545114 chr13:79997879 G/A cg07061582 chr15:90234082 PEX11A;WDR93 0.41 5.97 0.31 6.15e-9 Schizophrenia; CRC cis rs11955398 0.647 rs6449483 chr5:59995393 C/T cg02684056 chr5:59996105 DEPDC1B 0.43 6.12 0.32 2.62e-9 Intelligence (multi-trait analysis); CRC cis rs7726839 0.574 rs72705014 chr5:619815 C/G cg17948913 chr5:572064 NA 0.51 5.91 0.31 8.58e-9 Obesity-related traits; CRC cis rs10504229 0.683 rs7822631 chr8:58130916 C/G cg05313129 chr8:58192883 C8orf71 -0.43 -6.11 -0.32 2.74e-9 Developmental language disorder (linguistic errors); CRC cis rs6076065 0.723 rs6076073 chr20:23414489 G/A cg11657817 chr20:23433608 CST11 0.42 6.19 0.32 1.76e-9 Facial morphology (factor 15, philtrum width); CRC cis rs7605827 0.897 rs10166702 chr2:15528454 T/C cg19274914 chr2:15703543 NA 0.39 5.92 0.31 7.9e-9 Educational attainment (years of education); CRC cis rs589448 0.967 rs2617834 chr12:69753365 T/C cg14784868 chr12:69753453 YEATS4 0.91 17.35 0.69 2.44e-48 Cerebrospinal fluid biomarker levels; CRC cis rs6831352 0.879 rs67311928 chr4:100048999 A/G cg12011299 chr4:100065546 ADH4 -0.49 -9.27 -0.45 2.61e-18 Alcohol dependence; CRC cis rs10028773 0.666 rs35231872 chr4:120248376 A/T cg09307838 chr4:120376055 NA 0.64 9.48 0.46 5.15e-19 Educational attainment; CRC cis rs6424115 0.830 rs2501426 chr1:24199364 G/A cg15997130 chr1:24165203 NA 0.72 10.6 0.5 9.06e-23 Immature fraction of reticulocytes; CRC cis rs6743376 0.533 rs10206428 chr2:113826475 A/G cg09040174 chr2:113837401 NA 0.41 6.2 0.32 1.71e-9 Inflammatory biomarkers; CRC cis rs9488822 0.676 rs11153594 chr6:116354591 A/G cg00430287 chr6:116382876 FRK -0.2 -5.96 -0.31 6.65e-9 Cholesterol, total;LDL cholesterol; CRC cis rs503341 0.756 rs612010 chr11:63591005 G/A cg04362095 chr11:63592001 C11orf84 -0.55 -8.9 -0.44 3.78e-17 Pulse pressure; CRC cis rs1707322 1.000 rs4660318 chr1:46334876 A/G cg03146154 chr1:46216737 IPP 0.5 6.97 0.36 1.7e-11 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg19857114 chr3:176741225 TBL1XR1 -0.49 -8.18 -0.41 6.12e-15 Liver disease severity in Alagille syndrome; CRC cis rs4268898 0.760 rs55863105 chr2:24570695 C/T cg06627628 chr2:24431161 ITSN2 0.44 6.33 0.33 8.19e-10 Asthma; CRC cis rs4285028 0.731 rs2877561 chr3:121712051 A/C cg20356878 chr3:121714668 ILDR1 0.52 7.66 0.39 2.09e-13 Multiple sclerosis; CRC cis rs2625529 0.652 rs2415128 chr15:72191073 T/C cg16672083 chr15:72433130 SENP8 0.44 6.47 0.34 3.48e-10 Red blood cell count; CRC cis rs9462846 0.692 rs1819325 chr6:42859748 C/A cg21280719 chr6:42927975 GNMT -0.34 -6.53 -0.34 2.49e-10 Blood protein levels; CRC cis rs10782582 0.609 rs2881785 chr1:76318096 T/C cg03433033 chr1:76189801 ACADM -0.43 -6.06 -0.32 3.73e-9 Daytime sleep phenotypes; CRC cis rs2303759 0.709 rs8102658 chr19:49828855 C/T cg24324837 chr19:49891574 CCDC155 0.53 6.94 0.36 2.13e-11 Multiple sclerosis; CRC cis rs709400 0.663 rs72710714 chr14:103981849 T/G cg12935359 chr14:103987150 CKB -0.54 -8.06 -0.41 1.46e-14 Body mass index; CRC cis rs6714710 0.603 rs34503448 chr2:98587288 A/G cg26665480 chr2:98280029 ACTR1B 0.56 7.62 0.39 2.74e-13 Posterior cortical atrophy and Alzheimer's disease; CRC cis rs780096 0.526 rs1647266 chr2:27693485 T/C cg24768116 chr2:27665128 KRTCAP3 -0.36 -8.12 -0.41 9.76e-15 Total body bone mineral density; CRC trans rs994014 0.846 rs1115919 chr4:82173397 A/G cg25444236 chr13:96329629 DNAJC3 -0.44 -5.97 -0.31 6.06e-9 Height; CRC cis rs9311474 0.607 rs4475032 chr3:52560021 C/T cg15147215 chr3:52552868 STAB1 -0.67 -11.76 -0.54 6.88e-27 Electroencephalogram traits; CRC cis rs17270561 0.579 rs10456326 chr6:25919662 G/A cg17691542 chr6:26056736 HIST1H1C 0.91 10.97 0.52 4.52e-24 Iron status biomarkers; CRC cis rs4731207 0.671 rs5022495 chr7:124444024 A/T cg23710748 chr7:124431027 NA 0.37 5.96 0.31 6.53e-9 Cutaneous malignant melanoma; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg17267835 chr6:161413433 MAP3K4 0.45 6.7 0.35 9.16e-11 Response to antipsychotic treatment; CRC cis rs10256972 0.577 rs6962809 chr7:1208889 A/G cg23708337 chr7:1209742 NA 0.53 8.14 0.41 8.34e-15 Longevity;Endometriosis; CRC cis rs7786877 0.521 rs2293767 chr7:100361675 A/G cg16850897 chr7:100343110 ZAN 0.5 7.26 0.37 2.89e-12 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs2882667 0.824 rs13189485 chr5:138475401 C/T cg04439458 chr5:138467593 SIL1 -0.39 -6.54 -0.34 2.34e-10 Age-related hearing impairment (SNP x SNP interaction); CRC trans rs11581859 0.950 rs17119203 chr1:99373662 C/T cg12183875 chr3:169587454 LRRC31 0.27 6.37 0.33 6.5e-10 Response to cognitive-behavioural therapy in anxiety disorder; CRC trans rs2727020 0.729 rs685789 chr11:49241228 G/A cg11707556 chr5:10655725 ANKRD33B 0.37 6.72 0.35 7.93e-11 Coronary artery disease; CRC cis rs2346177 0.811 rs4953373 chr2:46652145 G/C cg26688816 chr2:46740690 ATP6V1E2 -0.51 -8.24 -0.41 4.03e-15 HDL cholesterol; CRC trans rs6426142 0.790 rs2050627 chr1:224824195 A/G cg11504805 chr13:114815119 RASA3 -0.51 -5.96 -0.31 6.36e-9 Cancer; CRC cis rs2976388 0.609 rs1594999 chr8:143790574 G/A cg12516270 chr8:143859308 LYNX1 0.44 7.93 0.4 3.55e-14 Urinary tract infection frequency; CRC cis rs4478858 0.746 rs60073066 chr1:31689589 G/A cg00250761 chr1:31883323 NA 0.31 5.92 0.31 8.29e-9 Alcohol dependence; CRC cis rs611744 0.647 rs633901 chr8:109242981 G/T cg21045802 chr8:109455806 TTC35 0.41 6.62 0.34 1.48e-10 Dupuytren's disease; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg16365086 chr5:150603689 CCDC69 0.43 6.29 0.33 1.02e-9 Intelligence (multi-trait analysis); CRC cis rs3771570 1.000 rs16843590 chr2:242298228 G/A cg21155796 chr2:242212141 HDLBP 0.65 7.02 0.36 1.29e-11 Prostate cancer; CRC cis rs6570726 0.846 rs6919684 chr6:145883801 A/G cg13319975 chr6:146136371 FBXO30 -0.43 -6.38 -0.33 5.9e-10 Lobe attachment (rater-scored or self-reported); CRC cis rs4332037 0.539 rs56016347 chr7:2060126 C/T cg02825527 chr7:2087843 MAD1L1 -0.48 -5.78 -0.3 1.75e-8 Bipolar disorder; CRC cis rs2404602 0.692 rs4886829 chr15:77091182 G/T cg03037974 chr15:76606532 NA 0.67 11.27 0.53 4.03e-25 Blood metabolite levels; CRC cis rs4594175 0.886 rs11157801 chr14:51622918 C/T cg23942311 chr14:51606299 NA 0.66 10.67 0.51 5.05e-23 Cancer; CRC cis rs4713118 0.513 rs149897 chr6:28006650 A/G cg23161317 chr6:28129485 ZNF389 0.45 6.56 0.34 2.05e-10 Parkinson's disease; CRC cis rs734999 0.545 rs7368072 chr1:2556125 C/T cg20673091 chr1:2541236 MMEL1 0.37 5.91 0.31 8.75e-9 Ulcerative colitis; CRC cis rs78456975 1.000 rs13414537 chr2:1556330 C/T cg12573674 chr2:1569213 NA -0.74 -7.54 -0.38 4.61e-13 Placebo response in major depressive disorder (% change in symptom score); CRC cis rs10504229 1.000 rs67384205 chr8:58180348 C/G cg22535103 chr8:58192502 C8orf71 -0.82 -12.27 -0.56 9.63e-29 Developmental language disorder (linguistic errors); CRC cis rs1801251 1.000 rs2675974 chr2:233727071 A/G cg25237894 chr2:233734115 C2orf82 0.49 7.86 0.4 5.72e-14 Coronary artery disease; CRC cis rs1179624 0.679 rs12536918 chr7:75266699 C/T cg05145297 chr7:75264568 HIP1 0.63 8.68 0.43 1.8e-16 Age-related nuclear cataracts; CRC cis rs7727544 0.654 rs4705849 chr5:131559199 T/A cg02033258 chr5:131593261 PDLIM4 0.36 6.92 0.36 2.4e-11 Blood metabolite levels; CRC cis rs2120019 0.567 rs28844983 chr15:75178088 T/A cg09165964 chr15:75287851 SCAMP5 -0.63 -7.61 -0.39 2.98e-13 Blood trace element (Zn levels); CRC trans rs9825823 0.617 rs2083264 chr3:61074229 A/G cg01492649 chr11:86749237 TMEM135 0.43 6.03 0.32 4.48e-9 Depressive symptom measurement or major depressive disorder; CRC trans rs9771228 0.965 rs7806397 chr7:32303339 T/C cg02979224 chr7:93204462 CALCR 0.35 6.02 0.31 4.7e-9 Cognitive ability;Verbal-numerical reasoning; CRC cis rs2354432 0.607 rs57078845 chr1:146722222 G/A cg25205988 chr1:146714368 CHD1L -1.23 -9.97 -0.48 1.26e-20 Mitochondrial DNA levels; CRC cis rs12762955 0.561 rs7075141 chr10:1091195 C/T cg26597838 chr10:835615 NA -0.39 -5.79 -0.3 1.65e-8 Response to angiotensin II receptor blocker therapy; CRC cis rs10504229 0.683 rs7820559 chr8:58142662 C/T cg04204079 chr8:58130323 NA -0.45 -5.78 -0.3 1.69e-8 Developmental language disorder (linguistic errors); CRC cis rs67478160 0.529 rs12880413 chr14:104267407 A/G cg08213375 chr14:104286397 PPP1R13B 0.63 12.91 0.58 4.04e-31 Schizophrenia; CRC trans rs6546324 0.625 rs6717863 chr2:67844799 C/A cg00907274 chr3:27498161 SLC4A7 -0.49 -6.14 -0.32 2.38e-9 Endometriosis; CRC cis rs5758511 0.680 rs5758686 chr22:42655377 G/T cg00645731 chr22:42541494 CYP2D7P1 0.65 9.79 0.47 5.07e-20 Birth weight; CRC cis rs12220238 1.000 rs11000909 chr10:75944828 A/G cg19889307 chr10:75911429 ADK;AP3M1 0.59 5.64 0.3 3.63e-8 Soluble interleukin-2 receptor subunit alpha; CRC cis rs35110281 0.837 rs2838340 chr21:45076373 A/G cg04455712 chr21:45112962 RRP1B 0.39 7.62 0.39 2.75e-13 Mean corpuscular volume; CRC cis rs8180040 0.715 rs6772670 chr3:47191349 G/A cg27129171 chr3:47204927 SETD2 0.68 11.12 0.52 1.36e-24 Colorectal cancer; CRC trans rs7939886 0.920 rs7112964 chr11:55866408 T/C cg03929089 chr4:120376271 NA 0.66 5.96 0.31 6.44e-9 Myopia (pathological); CRC cis rs501120 0.584 rs11238929 chr10:44708596 T/A cg09554077 chr10:44749378 NA 0.65 7.29 0.37 2.37e-12 Coronary artery disease;Coronary heart disease; CRC cis rs870825 0.616 rs7678616 chr4:185648714 T/G cg04058563 chr4:185651563 MLF1IP 0.72 9.3 0.46 2.04e-18 Blood protein levels; CRC cis rs6502050 0.835 rs35555954 chr17:80122438 T/C cg19223190 chr17:80058835 NA 0.41 6.56 0.34 2.12e-10 Life satisfaction; CRC cis rs6694672 1.000 rs12677 chr1:197053373 G/A cg13682187 chr1:196946512 CFHR5 0.48 7.65 0.39 2.3e-13 Asthma; CRC cis rs875971 0.862 rs6971059 chr7:66067032 A/G cg11764359 chr7:65958608 NA -0.6 -8.93 -0.44 3.13e-17 Aortic root size; CRC cis rs7584330 0.697 rs9287620 chr2:238368730 C/T cg16989719 chr2:238392110 NA -0.44 -8.03 -0.4 1.72e-14 Prostate cancer; CRC cis rs4285028 0.948 rs1920309 chr3:121665479 G/A cg11130432 chr3:121712080 ILDR1 -0.51 -6.65 -0.34 1.23e-10 Multiple sclerosis; CRC cis rs2404602 0.692 rs12913810 chr15:77166675 T/C cg23625390 chr15:77176239 SCAPER 0.46 6.53 0.34 2.56e-10 Blood metabolite levels; CRC cis rs11622475 1.000 rs2236246 chr14:104379206 A/C cg20488157 chr14:104394430 TDRD9 -0.67 -9.25 -0.45 2.86e-18 Bipolar disorder; CRC cis rs9296736 0.922 rs614956 chr6:53950865 G/A cg04374786 chr6:53939321 C6orf142 0.45 7.39 0.38 1.25e-12 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs172166 0.516 rs2791333 chr6:28111114 A/G cg12273811 chr6:28175739 NA 0.46 6.96 0.36 1.86e-11 Cardiac Troponin-T levels; CRC cis rs7829975 0.714 rs60315134 chr8:8670599 A/G cg08975724 chr8:8085496 FLJ10661 0.46 6.96 0.36 1.91e-11 Mood instability; CRC cis rs13191362 0.810 rs66921603 chr6:162996982 G/A cg23758597 chr6:163146217 PARK2 -0.55 -6.12 -0.32 2.61e-9 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs1215050 0.904 rs890469 chr4:98923293 T/C cg05340658 chr4:99064831 C4orf37 -0.42 -5.99 -0.31 5.4e-9 Waist-to-hip ratio adjusted for body mass index; CRC cis rs2032447 0.765 rs1935235 chr6:26067782 C/G cg03517284 chr6:25882590 NA -0.49 -6.69 -0.35 9.48e-11 Intelligence (multi-trait analysis); CRC cis rs67981189 0.579 rs2240533 chr14:71541026 T/C cg15910301 chr14:71632612 NA 0.31 6.18 0.32 1.95e-9 Schizophrenia; CRC cis rs12519773 0.526 rs4285204 chr5:92528272 C/T cg18783429 chr5:92414398 NA 0.28 5.94 0.31 7.45e-9 Migraine; CRC cis rs561341 1.000 rs483301 chr17:30293398 G/T cg23018236 chr17:30244563 NA -0.65 -7.74 -0.39 1.21e-13 Hip circumference adjusted for BMI; CRC cis rs6963495 0.818 rs116457537 chr7:105152072 A/G cg13798780 chr7:105162888 PUS7 0.67 7.93 0.4 3.42e-14 Bipolar disorder (body mass index interaction); CRC cis rs881375 0.715 rs7858209 chr9:123645760 G/A cg09586646 chr9:123605570 PSMD5;LOC253039 0.4 5.73 0.3 2.3e-8 Rheumatoid arthritis; CRC cis rs3823572 0.525 rs2346445 chr7:133717904 T/C cg03336402 chr7:133662267 EXOC4 -0.66 -9.31 -0.46 1.9e-18 Intelligence (multi-trait analysis); CRC cis rs2811415 0.597 rs9827668 chr3:127775480 G/T cg13719885 chr3:127795394 NA -0.39 -5.95 -0.31 6.69e-9 Lung function (FEV1/FVC); CRC cis rs79349575 0.749 rs1057902 chr17:47005588 C/T cg00947319 chr17:47005597 UBE2Z -0.35 -6.08 -0.32 3.41e-9 Type 2 diabetes; CRC cis rs2404602 0.536 rs7165025 chr15:76766434 G/A cg03037974 chr15:76606532 NA 0.66 11.61 0.54 2.33e-26 Blood metabolite levels; CRC cis rs7178572 0.568 rs11858641 chr15:77585820 C/T cg22256960 chr15:77711686 NA -0.65 -9.46 -0.46 6.05e-19 Type 2 diabetes; CRC cis rs4969178 0.965 rs3817295 chr17:76394526 T/A cg05887092 chr17:76393375 PGS1 0.55 10.17 0.49 2.62e-21 HDL cholesterol levels; CRC cis rs4713118 0.662 rs4713120 chr6:27721835 C/A cg06470822 chr6:28175283 NA 0.61 8.88 0.44 4.53e-17 Parkinson's disease; CRC cis rs7107174 0.892 rs12281104 chr11:78046940 T/C cg02023728 chr11:77925099 USP35 0.49 8.63 0.43 2.75e-16 Testicular germ cell tumor; CRC cis rs4665809 1.000 rs17040322 chr2:26351274 G/C cg04944784 chr2:26401820 FAM59B -0.6 -7.67 -0.39 1.98e-13 Gut microbiome composition (summer); CRC cis rs6502050 0.835 rs4789678 chr17:80101078 C/T cg02741985 chr17:80059408 CCDC57 0.43 7.18 0.37 4.56e-12 Life satisfaction; CRC cis rs7772486 0.790 rs4896852 chr6:146284621 T/C cg13319975 chr6:146136371 FBXO30 0.41 6.07 0.32 3.51e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs6121246 0.567 rs6060261 chr20:30192948 C/G cg13852791 chr20:30311386 BCL2L1 0.6 8.21 0.41 5.04e-15 Mean corpuscular hemoglobin; CRC trans rs35110281 0.667 rs2070533 chr21:45122753 G/A cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.44 6.99 0.36 1.54e-11 Mean corpuscular volume; CRC cis rs713587 0.713 rs11125884 chr2:25239264 C/T cg04586622 chr2:25135609 ADCY3 -0.38 -6.78 -0.35 5.65e-11 Body mass index in non-asthmatics; CRC trans rs3780486 0.846 rs12554995 chr9:33132044 A/G cg20290983 chr6:43655470 MRPS18A 1.16 27.12 0.83 6.77e-86 IgG glycosylation; CRC cis rs6460942 0.555 rs7803268 chr7:12306793 G/A cg20607287 chr7:12443886 VWDE -0.6 -6.22 -0.32 1.55e-9 Coronary artery disease; CRC cis rs3772130 0.961 rs11716984 chr3:121362407 A/T cg20356878 chr3:121714668 ILDR1 0.49 7.65 0.39 2.22e-13 Cognitive performance; CRC cis rs7914558 0.966 rs4532960 chr10:104667406 C/T cg04362960 chr10:104952993 NT5C2 0.61 9.15 0.45 5.95e-18 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs9894429 0.966 rs6565604 chr17:79589242 G/A cg13777783 chr17:79615861 NA -0.3 -5.71 -0.3 2.53e-8 Eye color traits; CRC cis rs12745968 0.561 rs4847306 chr1:93216972 C/G cg17283838 chr1:93427260 FAM69A -0.44 -5.97 -0.31 5.99e-9 Bipolar disorder and schizophrenia; CRC cis rs796364 0.951 rs3098341 chr2:200792498 G/T cg23649088 chr2:200775458 C2orf69 0.55 6.01 0.31 4.94e-9 Schizophrenia; CRC cis rs9488822 0.676 rs12202181 chr6:116327102 A/G cg26893134 chr6:116381904 FRK 0.26 7.61 0.39 2.98e-13 Cholesterol, total;LDL cholesterol; CRC cis rs7659604 0.518 rs17452156 chr4:122733623 T/C cg20573242 chr4:122745356 CCNA2 0.57 8.3 0.42 2.74e-15 Type 2 diabetes; CRC cis rs56307353 0.513 rs2041120 chr19:1961474 C/T cg24355006 chr19:1969744 CSNK1G2 0.53 8.53 0.43 5.27e-16 Coronary artery disease; CRC cis rs10504229 0.645 rs56670121 chr8:58138872 C/T cg21724239 chr8:58056113 NA 0.49 6.76 0.35 6.24e-11 Developmental language disorder (linguistic errors); CRC cis rs2836974 0.965 rs8131126 chr21:40655754 A/G cg11644478 chr21:40555479 PSMG1 0.72 10.32 0.49 8.13e-22 Cognitive function; CRC cis rs11958404 0.719 rs72818153 chr5:157487035 T/C cg05962755 chr5:157440814 NA 1.04 12.93 0.58 3.41e-31 IgG glycosylation; CRC trans rs10506458 1.000 rs12580997 chr12:63433420 G/A cg22491629 chr6:157744540 C6orf35 -0.71 -8.53 -0.43 5.35e-16 Hemostatic factors and hematological phenotypes; CRC cis rs4713118 0.866 rs9468217 chr6:27726467 G/A cg03623178 chr6:28175578 NA 0.7 8.4 0.42 1.32e-15 Parkinson's disease; CRC cis rs172166 0.515 rs2622320 chr6:28115336 T/A cg21251018 chr6:28226885 NKAPL 0.57 10.06 0.49 6.22e-21 Cardiac Troponin-T levels; CRC cis rs2415984 0.570 rs28674745 chr14:46924415 G/C cg14871534 chr14:47121158 RPL10L -0.44 -6.28 -0.33 1.06e-9 Number of children ever born; CRC cis rs7517126 1.000 rs2336505 chr1:196843655 A/G cg13682187 chr1:196946512 CFHR5 -0.35 -5.7 -0.3 2.69e-8 Blood protein levels; CRC cis rs10189230 0.967 rs1367241 chr2:222353413 G/A cg14652038 chr2:222343519 EPHA4 0.52 10.02 0.48 8.14e-21 Urate levels in lean individuals; CRC cis rs10256972 0.591 rs11766651 chr7:1161646 A/G cg18402987 chr7:1209562 NA 0.52 7.66 0.39 2.15e-13 Longevity;Endometriosis; CRC cis rs7833790 0.724 rs6473311 chr8:82726682 G/A cg27398817 chr8:82754497 SNX16 -0.44 -6.06 -0.32 3.76e-9 Diastolic blood pressure; CRC cis rs2739330 0.760 rs1007888 chr22:24241101 C/T cg04234412 chr22:24373322 LOC391322 -0.79 -13.46 -0.6 3.22e-33 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs12580194 0.556 rs61249728 chr12:55728922 A/G cg23425280 chr12:56401806 NA 0.47 5.95 0.31 6.88e-9 Cancer; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg08498830 chr11:832797 CD151 0.43 6.16 0.32 2.14e-9 Response to antipsychotic treatment; CRC cis rs12142240 0.698 rs72679807 chr1:46846490 G/A cg14993813 chr1:46806288 NSUN4 -0.48 -6.03 -0.32 4.47e-9 Menopause (age at onset); CRC cis rs7149337 0.869 rs7159770 chr14:51691835 G/A cg03361068 chr14:51561562 TRIM9 0.28 5.74 0.3 2.21e-8 Cancer; CRC cis rs2404602 0.647 rs11072626 chr15:77090826 A/G cg03037974 chr15:76606532 NA -0.55 -8.08 -0.41 1.25e-14 Blood metabolite levels; CRC cis rs9942416 0.601 rs114547168 chr5:74991903 A/G cg00601450 chr5:74908170 NA 0.38 5.73 0.3 2.28e-8 Age-related disease endophenotypes; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg24928043 chr6:44191279 SLC29A1 0.37 6.14 0.32 2.36e-9 Liver disease severity in Alagille syndrome; CRC cis rs9372498 0.536 rs62424172 chr6:118777533 C/A cg24463073 chr6:118973353 C6orf204 0.52 6.84 0.35 3.84e-11 Diastolic blood pressure; CRC cis rs2721195 0.967 rs748193 chr8:145682115 C/T cg26752003 chr8:145688521 CYHR1 -0.54 -9.0 -0.44 1.86e-17 Age at first birth; CRC cis rs10193935 0.901 rs2118889 chr2:42451683 G/T cg27598129 chr2:42591480 NA -0.56 -6.58 -0.34 1.83e-10 Colonoscopy-negative controls vs population controls; CRC cis rs1552244 1.000 rs7615646 chr3:10089773 A/C cg13047869 chr3:10149882 C3orf24 0.57 7.8 0.4 8.27e-14 Alzheimer's disease; CRC cis rs2857891 0.773 rs2638100 chr11:6969676 C/G cg04053776 chr11:6947353 ZNF215 0.42 5.98 0.31 5.92e-9 Response to cytadine analogues (cytosine arabinoside); CRC cis rs4713118 0.539 rs200951 chr6:27835930 A/G cg26587870 chr6:27730563 NA -0.44 -6.74 -0.35 6.91e-11 Parkinson's disease; CRC cis rs6860806 0.507 rs272872 chr5:131675864 C/T cg24060327 chr5:131705240 SLC22A5 0.45 6.72 0.35 8.06e-11 Breast cancer; CRC cis rs12134245 0.776 rs6688261 chr1:91987034 C/T cg25838465 chr1:92012736 NA -0.71 -14.15 -0.62 7.92e-36 Breast cancer; CRC cis rs7727544 0.661 rs273900 chr5:131694606 G/A cg24060327 chr5:131705240 SLC22A5 -0.39 -6.43 -0.33 4.6e-10 Blood metabolite levels; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg13961709 chr14:74486189 C14orf45;ENTPD5 0.55 7.24 0.37 3.25e-12 Thyroid stimulating hormone; CRC trans rs3931020 0.720 rs927904 chr1:75260328 A/G cg22171725 chr15:72523569 PKM2 0.49 6.22 0.32 1.53e-9 Resistin levels; CRC cis rs9527 0.590 rs10883834 chr10:104881402 T/C cg15744005 chr10:104629667 AS3MT -0.31 -6.1 -0.32 3.05e-9 Arsenic metabolism; CRC cis rs2645694 0.626 rs2703119 chr4:77823640 C/T cg06046430 chr4:77819534 ANKRD56 0.41 5.6 0.3 4.47e-8 Emphysema distribution in smoking; CRC cis rs300703 0.935 rs417829 chr2:206851 A/G cg21211680 chr2:198530 NA 0.93 9.18 0.45 5.08e-18 Blood protein levels; CRC cis rs11123170 0.569 rs1049137 chr2:113975110 A/G cg21482265 chr2:113992762 PAX8;LOC440839;LOC654433 0.5 6.01 0.31 5.04e-9 Renal function-related traits (BUN); CRC cis rs12188164 0.965 rs11744539 chr5:451425 C/T cg17553881 chr5:443987 EXOC3;C5orf55 -0.37 -7.9 -0.4 4.09e-14 Cystic fibrosis severity; CRC cis rs11233250 0.502 rs963575 chr11:82412298 A/G cg17391194 chr11:82401662 NA 0.39 6.03 0.32 4.3e-9 Glioblastoma;Glioma; CRC cis rs11122272 0.766 rs2790867 chr1:231548059 A/C cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX 0.63 9.79 0.48 4.91e-20 Hemoglobin concentration; CRC cis rs6461049 0.800 rs2398706 chr7:2156338 A/T cg08027265 chr7:2291960 NA -0.37 -6.37 -0.33 6.51e-10 Schizophrenia; CRC cis rs7208859 0.623 rs3752020 chr17:29111125 T/G cg13385521 chr17:29058706 SUZ12P 0.73 8.4 0.42 1.39e-15 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs10992471 0.603 rs6479422 chr9:95190694 G/T cg14631576 chr9:95140430 CENPP -0.41 -7.24 -0.37 3.14e-12 Visceral adipose tissue/subcutaneous adipose tissue ratio; CRC cis rs17376456 0.569 rs7736892 chr5:93205597 G/A cg09848695 chr5:92956644 FAM172A;MIR2277 -0.53 -5.97 -0.31 6.21e-9 Diabetic retinopathy; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg09264088 chr15:63569686 APH1B 0.38 6.01 0.31 4.85e-9 Liver disease severity in Alagille syndrome; CRC cis rs6570726 0.870 rs370653 chr6:145823642 G/A cg23711669 chr6:146136114 FBXO30 0.68 12.16 0.56 2.33e-28 Lobe attachment (rater-scored or self-reported); CRC cis rs736408 0.609 rs13061423 chr3:52790213 T/C cg07507251 chr3:52567010 NT5DC2 0.41 5.82 0.31 1.36e-8 Bipolar disorder; CRC cis rs10504229 0.679 rs17801003 chr8:58050930 A/G cg20607798 chr8:58055168 NA 0.52 6.14 0.32 2.44e-9 Developmental language disorder (linguistic errors); CRC cis rs9549367 0.789 rs71446682 chr13:113894908 A/G cg00898013 chr13:113819073 PROZ -0.45 -6.45 -0.33 4.09e-10 Platelet distribution width; CRC cis rs7843479 0.544 rs11135735 chr8:21791557 C/T cg17168535 chr8:21777572 XPO7 0.66 11.37 0.53 1.69e-25 Mean corpuscular volume; CRC cis rs6088590 1.000 rs2180276 chr20:33360785 T/A cg24642439 chr20:33292090 TP53INP2 0.6 10.96 0.52 4.76e-24 Coronary artery disease; CRC cis rs6586163 0.967 rs10887877 chr10:90753038 A/G cg13456138 chr10:90753195 FAS -0.44 -6.8 -0.35 5.07e-11 Chronic lymphocytic leukemia; CRC cis rs6933660 0.745 rs9371517 chr6:151739810 G/T cg10883421 chr6:151773342 RMND1;C6orf211 0.73 12.95 0.58 2.73e-31 Menarche (age at onset); CRC cis rs9611565 0.571 rs2050032 chr22:42152429 C/T cg03806693 chr22:41940476 POLR3H 0.69 9.47 0.46 5.63e-19 Vitiligo; CRC cis rs807669 0.903 rs1018764 chr22:19172006 T/C cg02655711 chr22:19163373 SLC25A1 0.98 21.21 0.76 1.53e-63 Metabolite levels; CRC cis rs2842992 0.830 rs752779 chr6:160133957 G/A cg19482086 chr6:160211437 TCP1;MRPL18 0.7 8.85 0.44 5.32e-17 Age-related macular degeneration (geographic atrophy); CRC trans rs916888 0.821 rs199504 chr17:44861003 C/T cg07870213 chr5:140052090 DND1 -0.86 -10.15 -0.49 3.12e-21 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs75059851 0.778 rs73034263 chr11:133808038 C/G cg17703048 chr11:133852993 NA -0.45 -6.03 -0.32 4.44e-9 Schizophrenia; CRC cis rs7781557 1.000 rs727175 chr7:102471780 T/C cg18108683 chr7:102477205 FBXL13 -0.56 -7.07 -0.36 9.05e-12 Colorectal adenoma (advanced); CRC cis rs806215 1.000 rs712704 chr7:127258208 A/G cg25922125 chr7:127225783 GCC1 -0.7 -7.18 -0.37 4.61e-12 Type 2 diabetes; CRC cis rs11645898 0.935 rs28419077 chr16:72196776 A/G cg14768367 chr16:72042858 DHODH -0.54 -6.24 -0.33 1.35e-9 Blood protein levels; CRC cis rs4713118 0.824 rs9468229 chr6:27750086 G/A cg26587870 chr6:27730563 NA -0.45 -6.55 -0.34 2.18e-10 Parkinson's disease; CRC cis rs1865760 0.593 rs3903852 chr6:25915147 G/T cg16482183 chr6:26056742 HIST1H1C 0.42 6.16 0.32 2.17e-9 Height; CRC cis rs6951245 1.000 rs28528096 chr7:1070912 G/C cg22907277 chr7:1156413 C7orf50 0.71 7.39 0.38 1.26e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs12586317 0.547 rs115019197 chr14:35503764 G/A cg05294307 chr14:35346193 BAZ1A -0.7 -7.6 -0.39 3.22e-13 Psoriasis; CRC cis rs9916302 0.904 rs8068427 chr17:37511517 G/A cg03013999 chr17:37608204 MED1 -0.46 -6.85 -0.35 3.7e-11 Glomerular filtration rate (creatinine); CRC cis rs763014 0.966 rs4247097 chr16:654224 G/A cg07343612 chr16:622815 PIGQ -0.82 -14.2 -0.62 5.17e-36 Height; CRC cis rs7224737 1.000 rs9889640 chr17:40293497 C/T cg00647820 chr17:40259828 DHX58 -0.46 -6.5 -0.34 3.04e-10 Fibrinogen levels; CRC trans rs6076960 0.682 rs6054065 chr20:6267920 G/A cg24759859 chr6:86352639 SYNCRIP 0.45 6.26 0.33 1.19e-9 Smooth-surface caries; CRC cis rs2252521 1.000 rs2252521 chr7:29041190 C/T cg11728747 chr7:29037910 CPVL 0.34 6.13 0.32 2.56e-9 Cognitive performance; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg16403912 chr8:23104730 CHMP7 0.45 6.67 0.35 1.06e-10 Intelligence (multi-trait analysis); CRC cis rs72945132 0.882 rs72945194 chr11:70138621 A/G cg14191688 chr11:70257035 CTTN 0.48 6.2 0.32 1.71e-9 Coronary artery disease; CRC cis rs10504229 0.639 rs11781834 chr8:58133422 C/T cg05313129 chr8:58192883 C8orf71 -0.42 -5.84 -0.31 1.23e-8 Developmental language disorder (linguistic errors); CRC cis rs7737355 0.947 rs40400 chr5:130831365 C/T cg06307176 chr5:131281290 NA -0.41 -5.96 -0.31 6.63e-9 Life satisfaction; CRC cis rs9733 0.596 rs6661872 chr1:150628357 C/G cg10589385 chr1:150898437 SETDB1 0.28 5.98 0.31 5.86e-9 Tonsillectomy; CRC trans rs3749237 0.964 rs11714957 chr3:49776178 C/T cg21659725 chr3:3221576 CRBN 0.57 7.99 0.4 2.23e-14 Resting heart rate; CRC cis rs1044826 0.642 rs1580642 chr3:139132203 A/C cg15131784 chr3:139108705 COPB2 -0.4 -5.82 -0.31 1.42e-8 Obesity-related traits; CRC cis rs9660992 0.512 rs12142402 chr1:205128215 A/T cg03948781 chr1:205179583 DSTYK 0.43 5.98 0.31 5.9e-9 Mean corpuscular volume;Mean platelet volume; CRC cis rs9443189 1.000 rs9443189 chr6:76495882 A/G cg01950844 chr6:76311363 SENP6 0.56 6.65 0.34 1.2e-10 Prostate cancer; CRC cis rs9814567 1.000 rs9828815 chr3:134265749 C/T cg06541857 chr3:134203789 ANAPC13;CEP63 -0.4 -6.12 -0.32 2.65e-9 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs10499694 0.933 rs12538938 chr7:50592313 A/G cg14593290 chr7:50529359 DDC -0.44 -6.38 -0.33 6.02e-10 Body mass index; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg19672329 chr7:98923317 ARPC1A 0.46 6.3 0.33 9.35e-10 Response to antipsychotic treatment; CRC cis rs7666738 0.830 rs10022331 chr4:98960392 C/A cg05340658 chr4:99064831 C4orf37 0.61 9.54 0.47 3.45e-19 Colonoscopy-negative controls vs population controls; CRC cis rs673253 0.556 rs489319 chr1:44131794 C/T cg10881128 chr1:44031826 PTPRF 0.23 6.11 0.32 2.88e-9 Intelligence (multi-trait analysis); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg23039201 chr2:27851887 GPN1;CCDC121 0.4 6.51 0.34 2.89e-10 Liver disease severity in Alagille syndrome; CRC trans rs2727020 0.553 rs3862350 chr11:49595912 A/C cg15704280 chr7:45808275 SEPT13 -0.93 -16.9 -0.68 1.5e-46 Coronary artery disease; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg17819983 chr9:140189914 NA -0.41 -6.11 -0.32 2.81e-9 Myopia (pathological); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg18331098 chr11:120081749 OAF 0.42 6.29 0.33 9.99e-10 Intelligence (multi-trait analysis); CRC cis rs9916302 0.861 rs752314 chr17:37410700 C/T cg15445000 chr17:37608096 MED1 0.41 9.08 0.45 1.06e-17 Glomerular filtration rate (creatinine); CRC cis rs1005277 0.541 rs2505193 chr10:38394638 G/C cg17219203 chr10:38645113 HSD17B7P2 -0.41 -5.77 -0.3 1.8e-8 Extrinsic epigenetic age acceleration; CRC cis rs2228479 1.000 rs2228479 chr16:89985940 G/A cg06656553 chr16:89960601 TCF25 -0.66 -5.93 -0.31 7.58e-9 Skin colour saturation; CRC cis rs2243480 1.000 rs316307 chr7:65570171 C/T cg12463550 chr7:65579703 CRCP 0.66 6.1 0.32 2.99e-9 Diabetic kidney disease; CRC cis rs9910055 0.529 rs228764 chr17:42185469 A/G cg09913183 chr17:42254507 C17orf65;ASB16 -0.49 -6.74 -0.35 6.95e-11 Total body bone mineral density; CRC cis rs1475911 1.000 rs2839466 chr21:43512324 A/G cg24372256 chr21:43528868 UMODL1;C21orf128 0.49 6.59 0.34 1.76e-10 IgG glycosylation; CRC cis rs25645 0.502 rs9895948 chr17:38108363 T/C cg24910161 chr17:38119198 GSDMA -0.36 -5.94 -0.31 7.28e-9 Myeloid white cell count; CRC cis rs11608355 0.545 rs1073780 chr12:109895143 T/C cg05360138 chr12:110035743 NA 0.75 7.63 0.39 2.49e-13 Neuroticism; CRC cis rs10504229 0.728 rs77197419 chr8:58150879 C/A cg08219700 chr8:58056026 NA 0.45 5.74 0.3 2.11e-8 Developmental language disorder (linguistic errors); CRC cis rs11098499 0.874 rs9995277 chr4:120108603 G/A cg24375607 chr4:120327624 NA 0.48 7.31 0.37 2.08e-12 Corneal astigmatism; CRC cis rs1570884 0.890 rs7333969 chr13:50123317 C/T cg03651054 chr13:50194643 NA 0.29 5.61 0.3 4.27e-8 Sum basophil neutrophil counts;Sum neutrophil eosinophil counts;Neutrophil count;Myeloid white cell count;Granulocyte count; CRC cis rs1577917 1.000 rs11759855 chr6:86610841 T/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.53 -6.61 -0.34 1.53e-10 Response to antipsychotic treatment; CRC trans rs7615952 1.000 rs7616044 chr3:125649354 G/C cg02007433 chr3:129722099 NA -0.44 -5.98 -0.31 5.81e-9 Blood pressure (smoking interaction); CRC cis rs2836974 0.590 rs9974757 chr21:40617244 T/C cg06238570 chr21:40685208 BRWD1 -0.81 -13.02 -0.58 1.5e-31 Cognitive function; CRC cis rs2282802 0.685 rs62385161 chr5:139635747 T/C cg26211634 chr5:139558579 C5orf32 0.4 6.8 0.35 5e-11 Intelligence (multi-trait analysis); CRC cis rs12980942 0.872 rs12974420 chr19:41798660 A/G cg25627403 chr19:41769009 HNRNPUL1 0.52 6.02 0.31 4.73e-9 Coronary artery disease; CRC cis rs9818758 0.607 rs35283189 chr3:49113668 T/C cg00383909 chr3:49044727 WDR6 1.31 12.49 0.57 1.48e-29 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; CRC cis rs524023 0.958 rs2021860 chr11:64361384 G/T cg06522879 chr11:64358276 SLC22A12 -0.59 -9.34 -0.46 1.54e-18 Urate levels in obese individuals; CRC cis rs10131894 0.611 rs174994 chr14:75434102 A/G cg08847533 chr14:75593920 NEK9 -0.69 -10.92 -0.52 6.83e-24 Coronary artery disease; CRC cis rs3736594 1.000 rs12477908 chr2:27987046 A/C cg27432699 chr2:27873401 GPN1 -0.59 -8.17 -0.41 6.53e-15 Fasting blood glucose;Fasting blood glucose (BMI interaction); CRC cis rs9303401 0.614 rs12947982 chr17:57140301 A/G cg10487724 chr17:56770010 TEX14;RAD51C 0.7 8.61 0.43 3.02e-16 Cognitive test performance; CRC cis rs8072100 0.764 rs2644349 chr17:45641743 G/A cg25173405 chr17:45401733 C17orf57 0.44 6.83 0.35 4.14e-11 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs826838 1.000 rs11609286 chr12:38875511 A/G cg26384229 chr12:38710491 ALG10B -0.75 -10.44 -0.5 3.26e-22 Heart rate; CRC cis rs6761276 0.899 rs11693750 chr2:113835602 C/T cg24553058 chr2:113831203 IL1F10 0.4 6.44 0.33 4.26e-10 Protein quantitative trait loci; CRC cis rs910316 0.763 rs175044 chr14:75472109 G/A cg03030879 chr14:75389066 RPS6KL1 0.41 6.16 0.32 2.1e-9 Height; CRC cis rs67311347 0.866 rs11712426 chr3:40330322 G/A cg09455208 chr3:40491958 NA 0.35 6.81 0.35 4.74e-11 Renal cell carcinoma; CRC cis rs8060686 0.641 rs13816 chr16:68055495 G/C cg26727032 chr16:67993705 SLC12A4 -0.61 -7.89 -0.4 4.44e-14 HDL cholesterol;Metabolic syndrome; CRC cis rs2976388 0.573 rs1529865 chr8:143789171 C/T cg05569086 chr8:143859399 LYNX1 0.38 6.74 0.35 7.09e-11 Urinary tract infection frequency; CRC cis rs10504229 1.000 rs66870803 chr8:58180022 G/C cg05313129 chr8:58192883 C8orf71 -0.47 -6.99 -0.36 1.49e-11 Developmental language disorder (linguistic errors); CRC cis rs6088580 0.634 rs6058070 chr20:33103521 G/C cg24642439 chr20:33292090 TP53INP2 0.41 6.7 0.35 9.2e-11 Glomerular filtration rate (creatinine); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg01766534 chr2:224822249 MRPL44 0.43 5.97 0.31 6.31e-9 Response to antipsychotic treatment; CRC cis rs875971 0.862 rs6460306 chr7:66060793 T/C cg11764359 chr7:65958608 NA -0.58 -8.63 -0.43 2.73e-16 Aortic root size; CRC cis rs1580019 0.563 rs10486509 chr7:32585443 C/G cg07520158 chr7:32535189 LSM5;AVL9 -0.53 -7.74 -0.39 1.26e-13 Cognitive ability; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg21126573 chr17:7755257 KDM6B 0.46 6.02 0.31 4.53e-9 Anxiety disorder; CRC cis rs2120019 0.938 rs59094290 chr15:75308561 G/T cg11632617 chr15:75315747 PPCDC -0.54 -7.25 -0.37 3.02e-12 Blood trace element (Zn levels); CRC cis rs780096 0.545 rs2280737 chr2:27589810 A/G cg24768116 chr2:27665128 KRTCAP3 -0.32 -7.05 -0.36 1.04e-11 Total body bone mineral density; CRC trans rs7267979 1.000 rs2258879 chr20:25279213 T/C cg17903999 chr18:56338584 MALT1 -0.42 -6.99 -0.36 1.52e-11 Liver enzyme levels (alkaline phosphatase); CRC cis rs7216064 0.953 rs62086044 chr17:65970837 G/T cg12091567 chr17:66097778 LOC651250 -0.56 -6.61 -0.34 1.59e-10 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CRC cis rs561341 1.000 rs8077092 chr17:30281992 T/C cg00745463 chr17:30367425 LRRC37B -0.77 -9.32 -0.46 1.77e-18 Hip circumference adjusted for BMI; CRC cis rs12286929 0.617 rs11607928 chr11:115102224 A/G cg04055981 chr11:115044050 NA 0.37 5.74 0.3 2.18e-8 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs9487051 0.872 rs9398197 chr6:109609988 C/A cg12927641 chr6:109611667 NA -0.38 -6.85 -0.35 3.7e-11 Reticulocyte fraction of red cells; CRC cis rs7731657 0.537 rs2097797 chr5:130355151 C/T cg08523029 chr5:130500466 HINT1 -0.45 -5.8 -0.3 1.57e-8 Fasting plasma glucose; CRC cis rs703842 0.642 rs10876994 chr12:58064737 A/C cg15848620 chr12:58087721 OS9 0.54 6.34 0.33 7.73e-10 Multiple sclerosis; CRC cis rs12476592 0.602 rs6546019 chr2:63817440 A/G cg10828910 chr2:63850056 LOC388955 0.49 6.06 0.32 3.75e-9 Childhood ear infection; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg06124975 chr6:107810578 SOBP 0.44 6.22 0.32 1.51e-9 Response to antipsychotic treatment; CRC cis rs9894429 0.789 rs7219915 chr17:79591813 C/T cg21028142 chr17:79581711 NPLOC4 0.33 6.97 0.36 1.77e-11 Eye color traits; CRC cis rs9486719 0.947 rs12210834 chr6:96890407 A/T cg06623918 chr6:96969491 KIAA0776 -0.81 -9.51 -0.46 4.17e-19 Migraine;Coronary artery disease; CRC cis rs11711311 1.000 rs7633832 chr3:113472292 T/C cg15478005 chr3:113465772 ATP6V1A;NAA50 0.43 5.98 0.31 5.92e-9 IgG glycosylation; CRC cis rs6502050 0.835 rs7405738 chr17:80084227 A/G cg22110888 chr17:80059540 CCDC57 -0.41 -6.39 -0.33 5.58e-10 Life satisfaction; CRC cis rs8014204 0.935 rs3742786 chr14:75373011 A/G cg06998765 chr14:75389618 RPS6KL1 0.23 5.63 0.3 3.9e-8 Caffeine consumption; CRC cis rs9467711 0.606 rs2235251 chr6:26431982 C/T cg16898833 chr6:26189333 HIST1H4D 0.94 7.65 0.39 2.25e-13 Autism spectrum disorder or schizophrenia; CRC cis rs9322193 0.847 rs880246 chr6:150167108 G/A cg15181151 chr6:150070149 PCMT1 0.3 5.74 0.3 2.2e-8 Lung cancer; CRC cis rs10751667 0.857 rs6597961 chr11:976677 T/C cg23136738 chr11:925521 AP2A2 -0.51 -8.22 -0.41 4.69e-15 Alzheimer's disease (late onset); CRC cis rs2836974 0.932 rs73221193 chr21:40554693 C/T cg11890956 chr21:40555474 PSMG1 1.09 18.57 0.72 3.71e-53 Cognitive function; CRC cis rs9896933 0.779 rs2256316 chr17:80693805 C/G cg02398342 chr17:80708632 TBCD;FN3K 0.53 6.24 0.33 1.37e-9 Bone mineral accretion in asthma (oral corticosteroid dose interaction); CRC trans rs8002861 0.935 rs7320988 chr13:44413523 C/T cg17145862 chr1:211918768 LPGAT1 0.75 15.13 0.64 1.23e-39 Leprosy; CRC cis rs1552244 1.000 rs13319597 chr3:10126312 A/C cg18598329 chr3:10140678 FANCD2;C3orf24 0.9 12.6 0.57 5.78e-30 Alzheimer's disease; CRC cis rs1971762 0.527 rs6580950 chr12:53926656 T/A cg06632207 chr12:54070931 ATP5G2 0.45 7.54 0.38 4.73e-13 Height; CRC cis rs1816752 0.905 rs9511266 chr13:25012504 C/G cg02811702 chr13:24901961 NA 0.47 6.55 0.34 2.28e-10 Obesity-related traits; CRC cis rs7119 0.717 rs12910951 chr15:77806797 A/G cg10437265 chr15:77819839 NA 0.67 11.95 0.55 1.41e-27 Type 2 diabetes; CRC cis rs9902453 0.845 rs3102559 chr17:28029723 T/C cg26525008 chr17:28256777 EFCAB5;SSH2 0.6 9.02 0.45 1.6e-17 Coffee consumption (cups per day); CRC cis rs7917772 0.629 rs1475646 chr10:104522564 G/T cg04362960 chr10:104952993 NT5C2 0.46 6.18 0.32 1.85e-9 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC cis rs7945705 0.818 rs2742552 chr11:8876852 C/T cg14711859 chr11:8959438 ASCL3 0.4 6.77 0.35 5.98e-11 Hemoglobin concentration; CRC cis rs501120 1.000 rs687175 chr10:44751910 C/T cg09554077 chr10:44749378 NA -0.89 -13.4 -0.59 5.55e-33 Coronary artery disease;Coronary heart disease; CRC cis rs6681460 0.625 rs6680364 chr1:67104834 G/A cg02459107 chr1:67143332 SGIP1 0.32 5.77 0.3 1.85e-8 Presence of antiphospholipid antibodies; CRC cis rs6952808 0.575 rs6950330 chr7:1953606 T/C cg04267008 chr7:1944627 MAD1L1 -0.63 -9.72 -0.47 8.69e-20 Bipolar disorder and schizophrenia; CRC cis rs34779708 0.966 rs12257770 chr10:35517234 A/G cg03585969 chr10:35415529 CREM 0.52 7.05 0.36 1.08e-11 Inflammatory bowel disease;Crohn's disease; CRC cis rs11971779 0.648 rs6946113 chr7:139106126 A/C cg07862535 chr7:139043722 LUC7L2 0.57 7.32 0.37 1.92e-12 Diisocyanate-induced asthma; CRC trans rs11722228 0.522 rs77691548 chr4:10136115 T/G cg26043149 chr18:55253948 FECH 1.13 19.08 0.72 3.72e-55 Gout;Urate levels;Serum uric acid levels; CRC cis rs4731207 0.596 rs1871770 chr7:124630839 G/T cg23710748 chr7:124431027 NA -0.39 -6.34 -0.33 7.73e-10 Cutaneous malignant melanoma; CRC cis rs62229266 0.659 rs2835258 chr21:37424365 G/A cg12218747 chr21:37451666 NA -0.38 -6.42 -0.33 4.65e-10 Mitral valve prolapse; CRC cis rs6502050 0.835 rs67634087 chr17:80118168 C/T cg02741985 chr17:80059408 CCDC57 0.44 7.05 0.36 1.05e-11 Life satisfaction; CRC cis rs9911578 1.000 rs9892795 chr17:57023054 G/C cg05425664 chr17:57184151 TRIM37 -0.5 -7.88 -0.4 4.85e-14 Intelligence (multi-trait analysis); CRC cis rs7772486 0.905 rs9373486 chr6:146446024 C/G cg23711669 chr6:146136114 FBXO30 -0.64 -10.9 -0.51 8.19e-24 Lobe attachment (rater-scored or self-reported); CRC cis rs4285028 0.747 rs77790376 chr3:121492211 C/T cg11130432 chr3:121712080 ILDR1 -0.54 -6.31 -0.33 9.1e-10 Multiple sclerosis; CRC cis rs561341 0.660 rs7406043 chr17:30220152 C/G cg12193833 chr17:30244370 NA -0.61 -7.36 -0.38 1.5e-12 Hip circumference adjusted for BMI; CRC cis rs6502050 0.769 rs8079122 chr17:80120427 G/T cg11859384 chr17:80120422 CCDC57 -0.36 -5.72 -0.3 2.43e-8 Life satisfaction; CRC cis rs7705042 0.865 rs166079 chr5:141528959 C/T cg07392085 chr5:141489673 NDFIP1 0.46 7.35 0.38 1.6e-12 Asthma; CRC cis rs12692738 0.526 rs355843 chr2:165622946 A/G cg03182029 chr2:165697222 COBLL1 0.51 5.98 0.31 5.74e-9 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);Waist-to-hip ratio adjusted for BMI in non-smokers;Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction);Waist-to-hip ratio adjusted for body mass index; CRC cis rs1552244 0.882 rs68080705 chr3:10025743 C/T cg18598329 chr3:10140678 FANCD2;C3orf24 -0.8 -10.45 -0.5 2.85e-22 Alzheimer's disease; CRC cis rs17767392 0.871 rs35468256 chr14:71839524 A/G cg13720639 chr14:72061746 SIPA1L1 -0.54 -6.77 -0.35 5.81e-11 Mitral valve prolapse; CRC cis rs35883536 0.935 rs1106347 chr1:101149059 A/T cg14515779 chr1:101123966 NA -0.44 -8.4 -0.42 1.33e-15 Monocyte count; CRC cis rs17092148 0.887 rs4302281 chr20:33171645 C/T cg08999081 chr20:33150536 PIGU -0.45 -5.89 -0.31 9.34e-9 Neuroticism; CRC cis rs1799949 0.930 rs3092987 chr17:41222723 T/C cg01879757 chr17:41196368 BRCA1 -0.41 -6.11 -0.32 2.83e-9 Menopause (age at onset); CRC cis rs2976388 0.609 rs2572908 chr8:143802636 A/G cg12516270 chr8:143859308 LYNX1 0.4 7.1 0.36 7.66e-12 Urinary tract infection frequency; CRC cis rs6502050 0.835 rs7501527 chr17:80099355 A/C cg25804541 chr17:80189381 SLC16A3 -0.3 -5.73 -0.3 2.24e-8 Life satisfaction; CRC cis rs2530545 0.512 rs2893482 chr7:34629104 C/T cg14401837 chr7:34697493 NPSR1 -0.36 -5.63 -0.3 3.82e-8 IgG glycosylation; CRC cis rs7666738 0.830 rs11944035 chr4:98931618 C/T cg05340658 chr4:99064831 C4orf37 0.6 9.35 0.46 1.41e-18 Colonoscopy-negative controls vs population controls; CRC cis rs2760061 0.599 rs644794 chr1:228148670 T/C cg18477163 chr1:228402036 OBSCN -0.37 -6.04 -0.32 4.18e-9 Diastolic blood pressure; CRC cis rs6933660 0.646 rs6915598 chr6:151778664 T/C cg10883421 chr6:151773342 RMND1;C6orf211 0.56 7.94 0.4 3.22e-14 Menarche (age at onset); CRC cis rs853679 0.517 rs9393896 chr6:28127703 C/T cg02683197 chr6:28174875 NA 0.87 10.73 0.51 3.25e-23 Depression; CRC cis rs2836974 0.604 rs2854727 chr21:40713787 A/G cg11890956 chr21:40555474 PSMG1 0.67 9.91 0.48 1.92e-20 Cognitive function; CRC cis rs12586317 0.586 rs74243591 chr14:35520917 C/T cg16230307 chr14:35515116 FAM177A1 0.91 10.35 0.5 6.29e-22 Psoriasis; CRC trans rs2228479 0.702 rs3819574 chr16:89826630 G/A cg24644049 chr4:85504048 CDS1 0.86 6.93 0.36 2.29e-11 Skin colour saturation; CRC cis rs6960043 0.818 rs13220985 chr7:15062694 A/G cg19272540 chr7:15055459 NA 0.23 6.16 0.32 2.12e-9 Type 2 diabetes; CRC cis rs13144136 0.687 rs11734917 chr4:10660359 C/T cg10242279 chr4:10666415 CLNK -0.38 -6.46 -0.34 3.73e-10 Resistance to antihypertensive treatment in hypertension; CRC cis rs2652834 0.904 rs2729827 chr15:63360564 C/T cg05507819 chr15:63340323 TPM1 0.49 6.9 0.36 2.73e-11 HDL cholesterol; CRC cis rs6598955 0.724 rs12132137 chr1:26631243 C/T cg00852783 chr1:26633632 UBXN11 0.41 6.7 0.35 8.91e-11 Obesity-related traits; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg14275779 chr17:40830236 PLEKHH3 0.48 6.74 0.35 7.14e-11 Response to antipsychotic treatment; CRC trans rs1656966 1.000 rs1656966 chr3:186466252 C/T cg21215811 chr17:40925428 VPS25 0.45 7.17 0.37 5.11e-12 Myopia (pathological); CRC cis rs62064224 0.553 rs9915115 chr17:30684858 A/G cg25809561 chr17:30822961 MYO1D 0.52 9.16 0.45 5.75e-18 Schizophrenia; CRC cis rs9910055 0.540 rs609292 chr17:42180436 G/A cg19774624 chr17:42201019 HDAC5 0.54 7.37 0.38 1.37e-12 Total body bone mineral density; CRC cis rs1403694 1.000 rs1624230 chr3:186438935 A/C cg04611788 chr3:186434169 KNG1 0.45 6.86 0.35 3.33e-11 Blood protein levels; CRC cis rs35110281 1.000 rs35110281 chr21:45068947 T/A cg01579765 chr21:45077557 HSF2BP -0.39 -7.48 -0.38 6.72e-13 Mean corpuscular volume; CRC cis rs8062405 1.000 rs62036626 chr16:28844284 A/G cg08761264 chr16:28874980 SH2B1 -0.42 -5.64 -0.3 3.73e-8 Cognitive ability (multi-trait analysis);Cognitive ability; CRC cis rs9326248 0.954 rs10790177 chr11:117048417 A/G cg15534755 chr11:117069859 TAGLN 0.34 6.67 0.35 1.09e-10 Blood protein levels; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg02971627 chr15:59042282 ADAM10 0.49 6.15 0.32 2.26e-9 Thyroid stimulating hormone; CRC cis rs13315871 0.790 rs115288459 chr3:58324283 A/G cg20936604 chr3:58311152 NA -0.76 -7.91 -0.4 4.04e-14 Cholesterol, total; CRC cis rs6951245 1.000 rs77702926 chr7:1088838 G/A cg21664854 chr7:1097933 C7orf50;GPR146 0.79 8.71 0.43 1.52e-16 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs55823223 0.564 rs12103594 chr17:73855279 C/T cg10935138 chr17:73851978 WBP2 0.56 6.98 0.36 1.59e-11 Psoriasis; CRC cis rs9992667 0.704 rs3900761 chr4:38611582 C/G cg19726192 chr4:38663646 FLJ13197 0.6 6.5 0.34 2.91e-10 Eosinophil percentage of granulocytes; CRC cis rs17711722 0.701 rs55773927 chr7:65337902 T/C cg00343986 chr7:65444356 GUSB 0.56 8.47 0.42 8.43e-16 Calcium levels; CRC cis rs7572733 0.537 rs2340688 chr2:198438425 A/G cg10820045 chr2:198174542 NA 0.36 6.18 0.32 1.91e-9 Dermatomyositis; CRC cis rs10463316 0.817 rs13359941 chr5:150802118 C/T cg03212797 chr5:150827313 SLC36A1 -0.47 -7.13 -0.37 6.27e-12 Metabolite levels (Pyroglutamine); CRC cis rs1451375 0.785 rs10278338 chr7:50630270 C/T cg18232548 chr7:50535776 DDC 0.49 6.79 0.35 5.29e-11 Malaria; CRC cis rs10071761 0.513 rs12518585 chr5:40361676 G/A cg09067459 chr5:40385259 NA -0.53 -7.11 -0.37 7.18e-12 Selective IgA deficiency; CRC cis rs6502050 0.835 rs4789677 chr17:80119842 A/G cg09264619 chr17:80180166 NA -0.35 -5.93 -0.31 7.47e-9 Life satisfaction; CRC cis rs780096 0.546 rs1528533 chr2:27595756 G/C cg27432699 chr2:27873401 GPN1 -0.5 -7.66 -0.39 2.14e-13 Total body bone mineral density; CRC cis rs9682041 0.660 rs34158232 chr3:170115360 T/C cg11886554 chr3:170076028 SKIL 0.7 8.36 0.42 1.8e-15 Glomerular filtration rate in non diabetics (creatinine);Glomerular filtration rate (creatinine); CRC cis rs834811 0.563 rs1121038 chr7:135879132 T/C cg01726295 chr7:135938950 NA 0.34 5.69 0.3 2.85e-8 Post-traumatic stress disorder; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg07376846 chr1:203765385 ZC3H11A 0.45 6.2 0.32 1.65e-9 Response to antipsychotic treatment; CRC cis rs2976388 0.609 rs1594999 chr8:143790574 G/A cg24046110 chr8:143859143 LYNX1 0.49 8.65 0.43 2.37e-16 Urinary tract infection frequency; CRC cis rs6952808 0.893 rs35487994 chr7:1920171 G/A cg14004847 chr7:1930337 MAD1L1 -0.43 -5.82 -0.31 1.42e-8 Bipolar disorder and schizophrenia; CRC cis rs951366 0.764 rs708725 chr1:205744138 G/T cg11965913 chr1:205819406 PM20D1 0.84 13.86 0.61 1e-34 Menarche (age at onset); CRC cis rs9733 0.596 rs11807058 chr1:150640475 G/A cg18016565 chr1:150552671 MCL1 0.46 6.74 0.35 6.91e-11 Tonsillectomy; CRC cis rs10540 1.000 rs78520676 chr11:517173 G/A cg03576123 chr11:487126 PTDSS2 -1.04 -10.77 -0.51 2.3e-23 Body mass index; CRC cis rs8180040 1.000 rs295442 chr3:47335881 A/C cg27129171 chr3:47204927 SETD2 0.66 10.8 0.51 1.82e-23 Colorectal cancer; CRC cis rs12922317 0.589 rs350215 chr16:12151283 A/G cg02368508 chr16:12060182 TNFRSF17 -0.39 -5.87 -0.31 1.05e-8 Schizophrenia; CRC cis rs1552244 1.000 rs113153120 chr3:10156398 G/A cg18598329 chr3:10140678 FANCD2;C3orf24 -0.88 -11.62 -0.54 2.25e-26 Alzheimer's disease; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg11601666 chr17:8286754 RPL26 0.41 6.42 0.33 4.69e-10 Intelligence (multi-trait analysis); CRC cis rs2842992 0.672 rs4708845 chr6:160219601 T/G cg11366901 chr6:160182831 ACAT2 0.97 14.02 0.61 2.38e-35 Age-related macular degeneration (geographic atrophy); CRC trans rs2303319 0.582 rs62187608 chr2:162431138 T/G cg00039960 chr17:7142925 PHF23 -0.73 -5.99 -0.31 5.63e-9 Cognitive function; CRC cis rs877282 0.853 rs11595507 chr10:756703 C/T cg17470449 chr10:769945 NA 0.61 7.96 0.4 2.78e-14 Uric acid levels; CRC cis rs853679 0.517 rs4711164 chr6:28115156 C/T cg25164649 chr6:28176230 NA 0.78 9.66 0.47 1.33e-19 Depression; CRC cis rs4713118 0.662 rs9468276 chr6:28027688 A/C cg12172441 chr6:28176163 NA 0.55 6.94 0.36 2.03e-11 Parkinson's disease; CRC cis rs910316 0.935 rs11159119 chr14:75636967 C/T cg03030879 chr14:75389066 RPS6KL1 0.47 7.21 0.37 3.87e-12 Height; CRC cis rs478304 0.654 rs11227260 chr11:65461158 G/T cg27068330 chr11:65405492 SIPA1 -0.8 -12.02 -0.55 7.62e-28 Acne (severe); CRC cis rs9916302 0.706 rs594794 chr17:37453485 T/C cg00129232 chr17:37814104 STARD3 0.57 7.22 0.37 3.66e-12 Glomerular filtration rate (creatinine); CRC trans rs8141529 0.507 rs5762936 chr22:29381377 A/G cg21948803 chr22:24024719 LOC91316 -0.58 -6.75 -0.35 6.88e-11 Lymphocyte counts; CRC cis rs910316 0.763 rs175044 chr14:75472109 G/A cg11812906 chr14:75593930 NEK9 -0.59 -8.9 -0.44 3.75e-17 Height; CRC cis rs2153535 0.580 rs9406172 chr6:8515464 T/A cg21535247 chr6:8435926 SLC35B3 0.48 7.31 0.37 2.09e-12 Motion sickness; CRC cis rs2952156 0.920 rs2941506 chr17:37833035 A/G cg20243544 chr17:37824526 PNMT 0.55 8.87 0.44 4.67e-17 Asthma; CRC cis rs4716602 0.622 rs36071136 chr7:156166303 G/C cg16983916 chr7:156159713 NA -0.33 -5.62 -0.3 4.02e-8 Anti-saccade response; CRC cis rs4713118 0.869 rs9283880 chr6:27715243 A/C cg02683197 chr6:28174875 NA 0.63 8.77 0.44 1e-16 Parkinson's disease; CRC cis rs3771570 1.000 rs62193208 chr2:242322430 G/A cg21155796 chr2:242212141 HDLBP 0.65 7.01 0.36 1.34e-11 Prostate cancer; CRC cis rs28386778 0.897 rs2584635 chr17:61865934 A/G cg11494091 chr17:61959527 GH2 0.62 10.57 0.5 1.09e-22 Prudent dietary pattern; CRC cis rs9916302 0.904 rs8081338 chr17:37406139 C/T cg07936489 chr17:37558343 FBXL20 -0.79 -11.74 -0.54 8.41e-27 Glomerular filtration rate (creatinine); CRC cis rs356992 0.830 rs356991 chr2:60744872 T/G cg08426369 chr2:60753602 BCL11A 0.54 7.46 0.38 8e-13 Educational attainment (years of education); CRC cis rs4975616 0.804 rs381949 chr5:1322468 G/A cg26373071 chr5:1325741 CLPTM1L 0.5 8.98 0.44 2.09e-17 Lung cancer; CRC cis rs2882667 1.000 rs10064130 chr5:138309307 C/T cg09476006 chr5:138032270 NA 0.46 7.37 0.38 1.41e-12 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs11098699 0.769 rs6812009 chr4:124215392 A/G cg09941581 chr4:124220074 SPATA5 0.42 6.28 0.33 1.05e-9 Mosquito bite size; CRC cis rs2742540 0.503 rs2653556 chr11:8906636 C/G cg12365402 chr11:9010492 NRIP3 -0.35 -5.84 -0.31 1.24e-8 Hematocrit; CRC cis rs951366 0.585 rs72750964 chr1:205675240 C/T cg23034840 chr1:205782522 SLC41A1 0.5 6.65 0.34 1.21e-10 Menarche (age at onset); CRC cis rs6502050 1.000 rs6502050 chr17:80058236 C/G cg19223190 chr17:80058835 NA -0.5 -8.11 -0.41 1e-14 Life satisfaction; CRC cis rs644799 0.662 rs35793328 chr11:95490896 G/T cg03916912 chr11:95522834 CEP57;FAM76B 0.77 11.82 0.55 4.25e-27 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs9322193 0.962 rs1112730 chr6:150087519 G/A cg07701084 chr6:150067640 NUP43 0.46 6.49 0.34 3.1e-10 Lung cancer; CRC cis rs11212617 1.000 rs609261 chr11:108158134 T/C cg14761454 chr11:108092087 ATM;NPAT 0.42 6.16 0.32 2.08e-9 Response to metformin in type 2 diabetes (glycemic); CRC cis rs7727544 0.684 rs274546 chr5:131699867 A/G cg07395648 chr5:131743802 NA -0.41 -6.38 -0.33 6.1e-10 Blood metabolite levels; CRC cis rs597539 0.731 rs664229 chr11:68624483 C/G cg21963583 chr11:68658836 MRPL21 0.59 10.32 0.49 8.43e-22 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs877282 1.000 rs12779159 chr10:772143 T/C cg06581033 chr10:766294 NA -0.5 -5.76 -0.3 1.93e-8 Uric acid levels; CRC cis rs7772486 0.686 rs9399565 chr6:146081906 G/T cg13319975 chr6:146136371 FBXO30 0.43 6.41 0.33 5.09e-10 Lobe attachment (rater-scored or self-reported); CRC cis rs6840360 0.642 rs2034061 chr4:152420756 C/T cg09659197 chr4:152720779 NA 0.33 6.54 0.34 2.34e-10 Intelligence (multi-trait analysis); CRC cis rs2346177 0.554 rs36006825 chr2:46708945 G/T cg02822958 chr2:46747628 ATP6V1E2 0.4 5.73 0.3 2.27e-8 HDL cholesterol; CRC cis rs10927875 0.631 rs945418 chr1:16344730 T/C cg21385522 chr1:16154831 NA 0.61 7.71 0.39 1.54e-13 Dilated cardiomyopathy; CRC cis rs6502050 0.835 rs8070014 chr17:80115247 T/G cg02741985 chr17:80059408 CCDC57 0.43 7.18 0.37 4.56e-12 Life satisfaction; CRC cis rs823143 0.570 rs1361754 chr1:205801872 C/T cg23034840 chr1:205782522 SLC41A1 -0.66 -10.73 -0.51 3.06e-23 Monocyte percentage of white cells; CRC cis rs11711311 1.000 rs3732793 chr3:113442198 C/A cg15478005 chr3:113465772 ATP6V1A;NAA50 0.45 6.15 0.32 2.19e-9 IgG glycosylation; CRC cis rs55871839 0.708 rs1562612 chr8:59817068 A/G cg07426533 chr8:59803705 TOX -0.34 -5.87 -0.31 1.06e-8 Pneumonia; CRC cis rs2857891 0.909 rs56026267 chr11:6940211 T/C cg06872519 chr11:6947619 ZNF215 0.58 5.79 0.3 1.68e-8 Response to cytadine analogues (cytosine arabinoside); CRC cis rs739401 0.595 rs6578304 chr11:2998279 A/G cg25174290 chr11:3078921 CARS -0.39 -5.87 -0.31 1.06e-8 Longevity; CRC cis rs9463078 0.616 rs2211393 chr6:44716366 A/C cg25276700 chr6:44698697 NA 0.32 8.07 0.41 1.31e-14 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg23653712 chr4:52904379 SGCB 0.46 6.49 0.34 3.14e-10 Anxiety disorder; CRC cis rs2976388 0.507 rs13259549 chr8:143838519 T/C cg12516270 chr8:143859308 LYNX1 0.56 9.85 0.48 3.12e-20 Urinary tract infection frequency; CRC cis rs9905704 0.918 rs302858 chr17:56692800 G/T cg12560992 chr17:57184187 TRIM37 0.56 7.65 0.39 2.25e-13 Testicular germ cell tumor; CRC cis rs6502050 0.835 rs8080423 chr17:80102279 A/G cg13198984 chr17:80129470 CCDC57 0.46 8.16 0.41 6.94e-15 Life satisfaction; CRC cis rs6499255 0.951 rs16959025 chr16:69695589 G/T cg05250797 chr16:70222502 NA -0.44 -6.14 -0.32 2.42e-9 IgE levels; CRC cis rs12142240 0.667 rs41293287 chr1:46808852 C/T cg14993813 chr1:46806288 NSUN4 -0.49 -6.22 -0.32 1.5e-9 Menopause (age at onset); CRC cis rs561341 1.000 rs473356 chr17:30321762 G/C cg00745463 chr17:30367425 LRRC37B -0.88 -9.71 -0.47 9.33e-20 Hip circumference adjusted for BMI; CRC cis rs1046896 0.519 rs9900369 chr17:80829807 G/A cg02711726 chr17:80685570 FN3KRP -0.52 -7.07 -0.36 9.57e-12 Glycated hemoglobin levels; CRC trans rs7829975 0.871 rs572307 chr8:8578811 T/C cg16141378 chr3:129829833 LOC729375 0.43 6.44 0.33 4.3e-10 Mood instability; CRC cis rs6598955 0.670 rs7522905 chr1:26609259 C/T cg04990556 chr1:26633338 UBXN11 -0.78 -13.17 -0.59 4.24e-32 Obesity-related traits; CRC trans rs11654801 0.947 rs716959 chr17:20916590 A/G cg23759823 chr7:139672531 TBXAS1 -0.48 -6.91 -0.36 2.47e-11 Mosquito bite size; CRC cis rs11148252 0.846 rs4886077 chr13:52998697 G/T cg02158880 chr13:53174818 NA 0.49 7.37 0.38 1.37e-12 Lewy body disease; CRC cis rs9311474 0.508 rs12637627 chr3:52619962 G/T cg18099408 chr3:52552593 STAB1 -0.48 -8.33 -0.42 2.18e-15 Electroencephalogram traits; CRC trans rs875971 0.660 rs2191268 chr7:66110224 C/T cg03609269 chr1:53393023 SCP2 -0.39 -6.15 -0.32 2.29e-9 Aortic root size; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg15798279 chr7:6523691 KDELR2 0.45 6.37 0.33 6.33e-10 Response to antipsychotic treatment; CRC cis rs3751196 0.808 rs56314567 chr12:104209772 C/T cg02344784 chr12:104178138 NT5DC3 0.69 7.11 0.36 7.23e-12 Sense of smell; CRC cis rs7224737 1.000 rs2014521 chr17:40283413 C/G cg02450064 chr17:40260053 DHX58 -0.43 -6.24 -0.33 1.38e-9 Fibrinogen levels; CRC cis rs644799 1.000 rs568668 chr11:95528209 G/A cg03916912 chr11:95522834 CEP57;FAM76B 0.95 18.07 0.71 3.39e-51 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs12762955 0.561 rs11253567 chr10:1054444 A/G cg26597838 chr10:835615 NA 0.48 6.34 0.33 7.5e-10 Response to angiotensin II receptor blocker therapy; CRC trans rs9929218 0.559 rs55907909 chr16:68805805 C/T cg04657470 chr2:198365150 HSPE1;HSPD1 0.91 15.84 0.66 2.1e-42 Colorectal cancer; CRC trans rs61931739 0.500 rs11053167 chr12:34387092 A/C cg26384229 chr12:38710491 ALG10B 0.67 8.87 0.44 4.75e-17 Morning vs. evening chronotype; CRC cis rs4665809 1.000 rs6729757 chr2:26285102 A/G cg26119090 chr2:26468346 HADHA;HADHB -0.61 -7.9 -0.4 4.35e-14 Gut microbiome composition (summer); CRC trans rs61931739 0.500 rs7306334 chr12:34482900 A/G cg26384229 chr12:38710491 ALG10B -0.68 -8.8 -0.44 7.66e-17 Morning vs. evening chronotype; CRC cis rs755249 0.567 rs72637906 chr1:39708302 G/A cg18385671 chr1:39797026 MACF1 -0.44 -6.09 -0.32 3.08e-9 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs6499255 0.951 rs10852457 chr16:69607853 C/T cg04110750 chr16:69646130 NFAT5 -0.54 -7.49 -0.38 6.47e-13 IgE levels; CRC cis rs9311474 0.607 rs4687625 chr3:52563718 C/T cg15147215 chr3:52552868 STAB1 -0.66 -11.7 -0.54 1.08e-26 Electroencephalogram traits; CRC cis rs2811415 0.561 rs9857061 chr3:127763226 A/G cg13719885 chr3:127795394 NA -0.39 -5.99 -0.31 5.56e-9 Lung function (FEV1/FVC); CRC trans rs11098499 0.954 rs7681544 chr4:120411255 T/C cg25214090 chr10:38739885 LOC399744 0.66 10.54 0.5 1.46e-22 Corneal astigmatism; CRC cis rs617791 0.530 rs10896073 chr11:65762814 T/C cg09783858 chr11:65769428 EIF1AD;BANF1 0.5 7.47 0.38 7.05e-13 Breast cancer; CRC cis rs4689388 0.727 rs1801213 chr4:6293696 C/G cg00701064 chr4:6280414 WFS1 0.71 11.38 0.53 1.57e-25 Type 2 diabetes and other traits;Type 2 diabetes; CRC cis rs992157 0.700 rs10165153 chr2:219159629 T/C cg04880052 chr2:219191631 PNKD 0.42 6.76 0.35 6.16e-11 Colorectal cancer; CRC cis rs688020 1.000 rs688020 chr7:4228553 C/T cg02004499 chr7:4244250 SDK1 0.34 5.61 0.3 4.19e-8 Liver fibrosis in pediatric non-alcoholic fatty acid liver disease; CRC cis rs939584 1.000 rs4854343 chr2:638107 G/A cg03610516 chr2:642275 NA 0.42 5.68 0.3 2.91e-8 Body mass index; CRC cis rs3008870 1.000 rs2009319 chr1:67481070 G/T cg08660285 chr1:67390436 MIER1;WDR78 1.05 15.42 0.65 9.26e-41 Lymphocyte percentage of white cells; CRC cis rs9372498 0.505 rs72956993 chr6:118949708 A/T cg18833306 chr6:118973337 C6orf204 0.45 5.81 0.3 1.49e-8 Diastolic blood pressure; CRC cis rs9287719 0.967 rs10203664 chr2:10752377 T/C cg00105475 chr2:10696890 NA 0.45 7.17 0.37 4.85e-12 Prostate cancer; CRC cis rs17711722 0.640 rs13237956 chr7:65318029 G/A cg11764359 chr7:65958608 NA 0.52 7.99 0.4 2.34e-14 Calcium levels; CRC cis rs954108 0.584 rs9314922 chr13:29379229 A/G cg11788234 chr13:29393811 NA 0.53 9.23 0.45 3.35e-18 Obesity-related traits; CRC cis rs4481887 0.741 rs6682957 chr1:248535639 T/G cg26353448 chr1:248524236 OR2T4 -0.34 -6.49 -0.34 3.09e-10 Common traits (Other); CRC cis rs10504229 0.683 rs77548248 chr8:58117542 G/A cg22535103 chr8:58192502 C8orf71 -0.7 -9.19 -0.45 4.45e-18 Developmental language disorder (linguistic errors); CRC cis rs9682041 0.696 rs6798399 chr3:170086482 G/A cg11886554 chr3:170076028 SKIL 0.7 8.29 0.42 2.85e-15 Glomerular filtration rate in non diabetics (creatinine);Glomerular filtration rate (creatinine); CRC cis rs9322193 1.000 rs9322193 chr6:149919143 T/G cg07701084 chr6:150067640 NUP43 0.47 6.65 0.34 1.22e-10 Lung cancer; CRC cis rs8180040 0.966 rs11130129 chr3:47489885 G/C cg27129171 chr3:47204927 SETD2 -0.62 -9.55 -0.47 3.16e-19 Colorectal cancer; CRC trans rs875971 0.660 rs2191268 chr7:66110224 C/T cg19689029 chr1:150898761 SETDB1 -0.38 -6.12 -0.32 2.64e-9 Aortic root size; CRC cis rs763121 0.853 rs9610986 chr22:39025277 T/C cg06544989 chr22:39130855 UNC84B 0.44 6.93 0.36 2.22e-11 Menopause (age at onset); CRC trans rs2727020 0.566 rs10839234 chr11:49185524 C/T cg03929089 chr4:120376271 NA -0.79 -13.2 -0.59 3.3e-32 Coronary artery disease; CRC cis rs7772486 0.754 rs9386132 chr6:146140751 T/C cg23711669 chr6:146136114 FBXO30 0.78 13.58 0.6 1.16e-33 Lobe attachment (rater-scored or self-reported); CRC cis rs929354 1.000 rs1182377 chr7:157048403 T/C cg05182265 chr7:156933206 UBE3C 0.67 12.33 0.56 5.6e-29 Body mass index; CRC cis rs447735 0.587 rs258335 chr16:89720944 G/A cg01097406 chr16:89675127 NA 0.44 8.52 0.43 5.83e-16 Hemoglobin concentration; CRC cis rs7659604 0.967 rs10008348 chr4:122666987 A/C cg20573242 chr4:122745356 CCNA2 0.43 6.3 0.33 9.36e-10 Type 2 diabetes; CRC cis rs7811142 0.943 rs73403312 chr7:100024153 T/C cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.15 17.19 0.69 1.08e-47 Platelet count; CRC cis rs910316 0.967 rs4903293 chr14:75656568 A/G cg03030879 chr14:75389066 RPS6KL1 0.43 6.47 0.34 3.59e-10 Height; CRC cis rs9467711 0.651 rs17587597 chr6:25986451 G/A cg12315302 chr6:26189340 HIST1H4D 0.78 6.15 0.32 2.21e-9 Autism spectrum disorder or schizophrenia; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg24437429 chr17:1012418 ABR 0.48 6.74 0.35 7.15e-11 Anxiety disorder; CRC cis rs9916302 0.898 rs8072297 chr17:37478048 A/T cg03013999 chr17:37608204 MED1 -0.43 -6.43 -0.33 4.39e-10 Glomerular filtration rate (creatinine); CRC cis rs3820068 0.705 rs6656907 chr1:15896984 A/G cg27534772 chr1:16042836 PLEKHM2 0.45 7.64 0.39 2.33e-13 Systolic blood pressure; CRC cis rs13191362 0.507 rs2846566 chr6:163059714 G/A cg06582575 chr6:163149167 PACRG;PARK2 -0.55 -8.29 -0.42 2.95e-15 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs7493 0.901 rs2237586 chr7:95051052 G/T cg21856205 chr7:94953877 PON1 -0.52 -6.57 -0.34 2.01e-10 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs2153535 0.580 rs1928184 chr6:8532108 T/A cg07606381 chr6:8435919 SLC35B3 0.67 10.93 0.52 6.05e-24 Motion sickness; CRC cis rs7715806 0.500 rs58968428 chr5:75004107 A/G cg19683494 chr5:74908142 NA 0.51 5.71 0.3 2.51e-8 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs4713118 0.911 rs9461406 chr6:27719764 C/T cg20933634 chr6:27740509 NA -0.5 -6.3 -0.33 9.43e-10 Parkinson's disease; CRC cis rs473651 0.935 rs482775 chr2:239335403 G/C cg08773314 chr2:239334832 ASB1 0.39 8.95 0.44 2.58e-17 Multiple system atrophy; CRC cis rs116095464 0.558 rs113796397 chr5:246503 A/G cg22496380 chr5:211416 CCDC127 -0.89 -10.0 -0.48 9.92e-21 Breast cancer; CRC cis rs7258465 1.000 rs10409483 chr19:18590223 C/G cg10790698 chr19:18539756 SSBP4 -0.45 -8.61 -0.43 3.07e-16 Breast cancer; CRC trans rs561341 0.941 rs112569713 chr17:30271738 C/T cg27661571 chr11:113659931 NA -0.77 -9.59 -0.47 2.24e-19 Hip circumference adjusted for BMI; CRC cis rs10484885 0.759 rs56230212 chr6:90234654 G/A cg13799429 chr6:90582589 CASP8AP2 -0.66 -6.52 -0.34 2.67e-10 QRS interval (sulfonylurea treatment interaction); CRC cis rs10754283 0.901 rs10922683 chr1:90116068 G/A cg21401794 chr1:90099060 LRRC8C 0.4 5.69 0.3 2.83e-8 Amyotrophic lateral sclerosis (sporadic); CRC cis rs741668 0.897 rs56223000 chr13:46602635 G/A cg06018095 chr13:46550134 ZC3H13 0.43 5.93 0.31 7.54e-9 Cerebrospinal fluid clusterin levels; CRC cis rs12711979 0.513 rs1454241 chr2:3851675 A/G cg17052675 chr2:3827356 NA 0.36 6.38 0.33 6.14e-10 Itch intensity from mosquito bite adjusted by bite size; CRC trans rs2470578 0.716 rs2733514 chr3:17323931 A/G cg26851410 chr19:2785307 THOP1 -0.43 -6.18 -0.32 1.91e-9 Schizophrenia; CRC cis rs10193935 0.901 rs9808509 chr2:42479644 T/C cg27598129 chr2:42591480 NA -0.68 -6.98 -0.36 1.63e-11 Colonoscopy-negative controls vs population controls; CRC cis rs7607369 0.559 rs6741592 chr2:219658609 C/T cg02176678 chr2:219576539 TTLL4 -0.41 -6.23 -0.33 1.39e-9 Red blood cell count;Amyotrophic lateral sclerosis; CRC cis rs4481887 0.708 rs6696691 chr1:248539720 T/C cg26353448 chr1:248524236 OR2T4 -0.33 -6.36 -0.33 6.59e-10 Common traits (Other); CRC cis rs4363385 0.643 rs12734348 chr1:152924650 A/G cg07796016 chr1:152779584 LCE1C -0.39 -5.73 -0.3 2.26e-8 Inflammatory skin disease; CRC cis rs7208859 0.673 rs73277978 chr17:29191449 A/G cg01831904 chr17:28903510 LRRC37B2 -0.55 -5.77 -0.3 1.88e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs3736485 0.966 rs12102203 chr15:51791559 A/G cg08986416 chr15:51914746 DMXL2 -0.42 -6.17 -0.32 2.06e-9 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs7586879 0.796 rs11684619 chr2:25078859 G/A cg22495460 chr2:25135724 ADCY3 -0.82 -13.57 -0.6 1.31e-33 Body mass index; CRC cis rs9549328 0.616 rs35086993 chr13:113617305 G/A cg24588162 chr13:113633484 MCF2L 0.36 6.51 0.34 2.89e-10 Systolic blood pressure; CRC cis rs4474465 0.850 rs4559714 chr11:78257302 C/T cg27205649 chr11:78285834 NARS2 0.52 6.68 0.35 1.01e-10 Alzheimer's disease (survival time); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg18115495 chr7:65579946 CRCP 0.44 7.59 0.39 3.39e-13 Liver disease severity in Alagille syndrome; CRC cis rs614226 0.938 rs7972244 chr12:120994872 A/G cg27489772 chr12:121021490 NA 0.49 6.7 0.35 9.31e-11 Type 1 diabetes nephropathy; CRC cis rs55788414 0.932 rs34444956 chr16:81185412 C/T cg06400318 chr16:81190750 PKD1L2 -0.59 -6.76 -0.35 6.2e-11 Left ventricular obstructive tract defect (maternal effect); CRC cis rs6724607 1.000 rs13410230 chr2:191446252 A/G cg21644426 chr2:191273491 MFSD6 0.45 6.16 0.32 2.09e-9 Pulse pressure; CRC cis rs4363385 0.693 rs440598 chr1:153044733 T/C cg25856811 chr1:152973957 SPRR3 -0.24 -6.58 -0.34 1.86e-10 Inflammatory skin disease; CRC cis rs1348850 0.645 rs11889272 chr2:178432378 C/T cg02961200 chr2:178257176 LOC100130691;AGPS 0.51 5.62 0.3 4.14e-8 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs1005277 0.505 rs10827835 chr10:38150709 G/A cg00409905 chr10:38381863 ZNF37A 0.62 10.3 0.49 9.78e-22 Extrinsic epigenetic age acceleration; CRC cis rs4728302 0.869 rs958404 chr7:133597186 G/T cg03336402 chr7:133662267 EXOC4 0.44 6.43 0.33 4.5e-10 Intelligence;Intelligence (multi-trait analysis); CRC cis rs1559088 0.649 rs4528686 chr19:33556074 A/G cg27124370 chr19:33622961 WDR88 0.42 5.79 0.3 1.67e-8 Bone ultrasound measurement (broadband ultrasound attenuation); CRC cis rs4253772 0.513 rs9306512 chr22:46716603 T/C cg03482458 chr22:46692211 CN5H6.4;GTSE1 0.57 7.68 0.39 1.78e-13 LDL cholesterol;Cholesterol, total; CRC cis rs9311474 0.502 rs4687624 chr3:52563572 C/T cg18099408 chr3:52552593 STAB1 -0.51 -8.9 -0.44 3.81e-17 Electroencephalogram traits; CRC cis rs7827545 0.961 rs4909482 chr8:135564786 G/T cg17885191 chr8:135476712 NA 0.54 7.41 0.38 1.06e-12 Hypertension (SNP x SNP interaction); CRC cis rs9911578 1.000 rs9892062 chr17:56976981 G/A cg05425664 chr17:57184151 TRIM37 -0.49 -7.67 -0.39 1.99e-13 Intelligence (multi-trait analysis); CRC cis rs1223397 0.651 rs2458314 chr6:13309224 C/T cg20827128 chr6:13274284 PHACTR1 0.44 6.93 0.36 2.21e-11 Blood pressure; CRC cis rs3760982 0.585 rs10422108 chr19:44294868 C/T cg11993925 chr19:44307056 LYPD5 0.56 10.14 0.49 3.25e-21 Breast cancer (estrogen-receptor negative);Breast cancer; CRC cis rs9926296 0.712 rs258319 chr16:89732024 A/T cg01097406 chr16:89675127 NA 0.53 9.53 0.47 3.54e-19 Vitiligo; CRC cis rs1816752 0.870 rs9511261 chr13:25012018 C/T cg02811702 chr13:24901961 NA 0.47 6.6 0.34 1.64e-10 Obesity-related traits; CRC trans rs2303319 0.504 rs62188960 chr2:162492578 A/C cg01191114 chr3:48936118 SLC25A20 -0.69 -6.0 -0.31 5.27e-9 Cognitive function; CRC cis rs62064224 0.589 rs9889607 chr17:30785585 A/C cg25809561 chr17:30822961 MYO1D -0.59 -11.15 -0.52 1.02e-24 Schizophrenia; CRC trans rs7615952 0.512 rs4234285 chr3:125404477 G/A cg03844506 chr4:4109441 NA -0.51 -7.65 -0.39 2.2e-13 Blood pressure (smoking interaction); CRC cis rs921968 0.541 rs41461846 chr2:219313354 A/G cg02176678 chr2:219576539 TTLL4 -0.58 -9.12 -0.45 7.41e-18 Mean corpuscular hemoglobin concentration; CRC trans rs7618501 1.000 rs35261599 chr3:49773236 G/A cg21582582 chr3:182698605 DCUN1D1 -0.56 -8.35 -0.42 1.88e-15 Intelligence (multi-trait analysis); CRC cis rs2806561 0.765 rs1738468 chr1:23510850 T/G cg12483005 chr1:23474871 LUZP1 0.5 7.25 0.37 3.09e-12 Height; CRC cis rs7772486 0.658 rs6570706 chr6:145962922 T/C cg13319975 chr6:146136371 FBXO30 -0.43 -6.37 -0.33 6.39e-10 Lobe attachment (rater-scored or self-reported); CRC cis rs9359856 0.564 rs72915904 chr6:90421412 C/A cg13799429 chr6:90582589 CASP8AP2 -0.71 -7.66 -0.39 2.08e-13 Bipolar disorder; CRC cis rs11212617 0.967 rs12272183 chr11:108077181 A/G cg01991180 chr11:108092276 ATM;NPAT 0.42 6.27 0.33 1.16e-9 Response to metformin in type 2 diabetes (glycemic); CRC cis rs11105298 0.891 rs10777185 chr12:89921275 C/T cg00757033 chr12:89920650 WDR51B 0.36 6.06 0.32 3.79e-9 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; CRC cis rs7666738 0.723 rs35327100 chr4:98977788 C/A cg17366294 chr4:99064904 C4orf37 0.44 7.44 0.38 8.98e-13 Colonoscopy-negative controls vs population controls; CRC cis rs3806843 0.900 rs2531341 chr5:140130894 C/T cg19875535 chr5:140030758 IK -0.53 -8.41 -0.42 1.22e-15 Depressive symptoms (multi-trait analysis); CRC trans rs6833159 0.527 rs10939231 chr4:28829372 A/T cg05681148 chr13:28195812 POLR1D;LNX2 -0.43 -6.09 -0.32 3.18e-9 Underweight status; CRC cis rs7666738 0.830 rs28618180 chr4:98912184 A/C cg05340658 chr4:99064831 C4orf37 0.57 8.54 0.43 5.08e-16 Colonoscopy-negative controls vs population controls; CRC cis rs1862618 0.641 rs252893 chr5:56224714 T/C cg20203395 chr5:56204925 C5orf35 -0.6 -8.17 -0.41 6.93e-15 Initial pursuit acceleration; CRC cis rs796364 0.950 rs188146 chr2:200750444 C/T cg23649088 chr2:200775458 C2orf69 0.54 5.98 0.31 5.68e-9 Schizophrenia; CRC cis rs9443645 0.901 rs9343860 chr6:79739010 G/A cg09184832 chr6:79620586 NA -0.51 -9.3 -0.46 2.01e-18 Intelligence (multi-trait analysis); CRC cis rs904251 0.504 rs12202664 chr6:37481198 A/G cg25019722 chr6:37503610 NA -0.42 -7.61 -0.39 2.98e-13 Cognitive performance; CRC cis rs853679 0.513 rs13437444 chr6:28070998 C/T cg06470822 chr6:28175283 NA 0.95 9.78 0.47 5.18e-20 Depression; CRC cis rs7107174 1.000 rs7119933 chr11:78049750 A/C cg12700464 chr11:78128424 GAB2 -0.48 -5.88 -0.31 1.03e-8 Testicular germ cell tumor; CRC cis rs72781680 0.752 rs55801864 chr2:23922325 C/T cg08917208 chr2:24149416 ATAD2B 1.01 9.32 0.46 1.67e-18 Lymphocyte counts; CRC cis rs55702914 0.742 rs6744206 chr2:198148522 A/G cg03934865 chr2:198174659 NA -0.4 -6.92 -0.36 2.38e-11 Major depression and alcohol dependence; CRC cis rs9611565 0.568 rs5758441 chr22:42132888 C/A cg03806693 chr22:41940476 POLR3H 0.66 9.31 0.46 1.9e-18 Vitiligo; CRC cis rs2976388 0.533 rs12543368 chr8:143819450 T/C cg20041105 chr8:143859282 LYNX1 -0.41 -6.55 -0.34 2.18e-10 Urinary tract infection frequency; CRC cis rs947211 0.950 rs1775145 chr1:205756143 C/A cg14159672 chr1:205819179 PM20D1 0.42 5.71 0.3 2.59e-8 Parkinson's disease; CRC cis rs6951245 1.000 rs11768761 chr7:1069807 A/G cg20603222 chr7:1096387 C7orf50;GPR146 -0.69 -8.1 -0.41 1.07e-14 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs881375 0.933 rs4837799 chr9:123668326 T/C cg09419670 chr9:123605666 PSMD5;LOC253039 0.6 8.85 0.44 5.52e-17 Rheumatoid arthritis; CRC cis rs17443541 0.507 rs7562008 chr2:200454560 A/G cg03741458 chr2:200468445 NA -0.38 -5.96 -0.31 6.56e-9 Intelligence (multi-trait analysis); CRC cis rs35883536 0.740 rs4604711 chr1:101089492 A/C cg14515779 chr1:101123966 NA -0.43 -8.4 -0.42 1.36e-15 Monocyte count; CRC trans rs61931739 0.500 rs11053193 chr12:34438838 G/T cg26384229 chr12:38710491 ALG10B 0.66 8.81 0.44 7.3e-17 Morning vs. evening chronotype; CRC cis rs4853012 0.941 rs2421752 chr2:74341615 A/G cg20891558 chr2:74357851 NA 0.68 10.54 0.5 1.39e-22 Gestational age at birth (maternal effect); CRC cis rs7945705 0.747 rs1980428 chr11:9010497 A/G cg12365402 chr11:9010492 NRIP3 0.57 10.72 0.51 3.31e-23 Hemoglobin concentration; CRC cis rs832540 0.931 rs832534 chr5:56213672 G/A cg24531977 chr5:56204891 C5orf35 -0.49 -7.54 -0.38 4.73e-13 Coronary artery disease; CRC cis rs4731207 0.596 rs4406330 chr7:124641491 T/C cg23710748 chr7:124431027 NA -0.38 -6.08 -0.32 3.27e-9 Cutaneous malignant melanoma; CRC trans rs1814175 0.647 rs61306292 chr11:49856040 G/C cg03929089 chr4:120376271 NA -0.98 -18.68 -0.72 1.4e-53 Height; CRC cis rs11628318 0.660 rs4906242 chr14:103085063 G/A cg08075719 chr14:103021372 NA -0.68 -7.94 -0.4 3.23e-14 Platelet count; CRC cis rs9896933 0.830 rs113051447 chr17:80791806 A/G cg20578329 chr17:80767326 TBCD -0.7 -9.22 -0.45 3.53e-18 Bone mineral accretion in asthma (oral corticosteroid dose interaction); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg19385725 chr18:21166173 NPC1 0.38 6.16 0.32 2.11e-9 Liver disease severity in Alagille syndrome; CRC cis rs1348850 0.597 rs4893964 chr2:178447658 G/T cg27490568 chr2:178487706 NA 0.44 6.01 0.31 4.84e-9 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs9311474 0.539 rs12489828 chr3:52567014 G/T cg18591801 chr3:52553433 STAB1 -0.29 -5.61 -0.3 4.2e-8 Electroencephalogram traits; CRC cis rs2361718 0.500 rs12451697 chr17:78100690 T/A cg27427491 chr17:78079615 GAA -0.49 -7.17 -0.37 4.9e-12 Yeast infection; CRC cis rs875971 0.862 rs10250544 chr7:65766561 A/G cg18252515 chr7:66147081 NA 0.4 5.63 0.3 3.84e-8 Aortic root size; CRC cis rs6912958 0.525 rs59322 chr6:88020521 C/A cg08069147 chr6:88032118 GJB7;C6orf162 0.72 11.53 0.54 4.49e-26 Monocyte percentage of white cells; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg18113596 chr7:57247912 LOC642006 -0.32 -6.16 -0.32 2.15e-9 Liver disease severity in Alagille syndrome; CRC cis rs4132509 1.000 rs6429433 chr1:243857994 C/T cg21452805 chr1:244014465 NA 0.51 6.75 0.35 6.84e-11 RR interval (heart rate); CRC cis rs1395 0.744 rs57881048 chr2:27474165 T/C cg14242246 chr2:27434262 C2orf28;SLC5A6 0.32 6.21 0.32 1.55e-9 Blood metabolite levels; CRC cis rs4654899 0.802 rs61781104 chr1:21257235 T/A cg02927042 chr1:21476669 EIF4G3 -0.48 -7.35 -0.38 1.59e-12 Superior frontal gyrus grey matter volume; CRC cis rs13108904 0.967 rs13109112 chr4:1290481 C/A cg00684032 chr4:1343700 KIAA1530 0.47 6.82 0.35 4.46e-11 Obesity-related traits; CRC cis rs6582630 0.598 rs10880645 chr12:38556172 G/A cg26384229 chr12:38710491 ALG10B -0.52 -7.52 -0.38 5.18e-13 Drug-induced liver injury (flucloxacillin); CRC cis rs17767392 0.918 rs12894016 chr14:71883088 G/T cg13720639 chr14:72061746 SIPA1L1 -0.55 -6.95 -0.36 1.96e-11 Mitral valve prolapse; CRC trans rs2727020 0.658 rs4980431 chr11:49350071 G/T cg15704280 chr7:45808275 SEPT13 -0.88 -16.17 -0.67 1.06e-43 Coronary artery disease; CRC cis rs4665809 1.000 rs12469163 chr2:26283587 T/C cg26119090 chr2:26468346 HADHA;HADHB -0.61 -7.85 -0.4 5.9e-14 Gut microbiome composition (summer); CRC cis rs7737355 0.898 rs3775998 chr5:130979332 A/G cg06307176 chr5:131281290 NA 0.42 6.08 0.32 3.42e-9 Life satisfaction; CRC cis rs10992471 0.756 rs7027595 chr9:95131553 C/T cg13798575 chr9:95087839 CENPP;NOL8 -0.48 -6.97 -0.36 1.79e-11 Visceral adipose tissue/subcutaneous adipose tissue ratio; CRC trans rs10982213 0.830 rs2274163 chr9:117188714 C/T cg05952120 chr17:61554416 ACE 0.41 6.5 0.34 2.9e-10 Interleukin-6 levels; CRC trans rs6703335 0.870 rs10803142 chr1:243598234 A/G cg09528111 chr14:31495531 AP4S1;STRN3 0.47 6.53 0.34 2.43e-10 Schizophrenia;Schizophrenia, schizoaffective disorder or bipolar disorder; CRC cis rs4925386 0.765 rs6142737 chr20:60919800 C/G cg15193198 chr20:60906057 LAMA5 -0.43 -6.35 -0.33 7.12e-10 Colorectal cancer;Colorectal cancer (SNP x SNP interaction); CRC cis rs11098499 0.954 rs11734241 chr4:120416872 A/G cg24375607 chr4:120327624 NA 0.48 7.34 0.38 1.69e-12 Corneal astigmatism; CRC cis rs7309 0.935 rs1921309 chr2:162048975 T/A cg16506815 chr2:162101123 NA 0.52 8.56 0.43 4.26e-16 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Educational attainment; CRC cis rs1018836 0.923 rs4735268 chr8:91629715 C/T cg16814680 chr8:91681699 NA -0.74 -11.29 -0.53 3.47e-25 Ejection fraction in Tripanosoma cruzi seropositivity; CRC cis rs2882667 0.931 rs10069528 chr5:138354027 A/G cg04439458 chr5:138467593 SIL1 -0.32 -5.89 -0.31 9.36e-9 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs7932354 0.502 rs11600668 chr11:47193566 G/A cg03339077 chr11:47165057 C11orf49 -0.46 -6.16 -0.32 2.06e-9 Bone mineral density (hip);Bone mineral density; CRC cis rs12893668 0.572 rs4900591 chr14:104154878 G/A cg08213375 chr14:104286397 PPP1R13B 0.44 6.95 0.36 1.95e-11 Reticulocyte count; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg23111772 chr20:62338704 ARFRP1;ZGPAT 0.4 6.29 0.33 1.03e-9 Liver disease severity in Alagille syndrome; CRC cis rs921968 0.643 rs4674319 chr2:219510320 C/T cg02176678 chr2:219576539 TTLL4 0.51 7.98 0.4 2.42e-14 Mean corpuscular hemoglobin concentration; CRC cis rs898097 0.812 rs55794221 chr17:80849003 G/A cg03160526 chr17:80928410 B3GNTL1 -0.41 -5.85 -0.31 1.21e-8 Breast cancer; CRC cis rs9527 0.590 rs7092029 chr10:104823909 A/T cg15744005 chr10:104629667 AS3MT -0.3 -5.96 -0.31 6.54e-9 Arsenic metabolism; CRC cis rs1046896 0.520 rs8074086 chr17:80818460 A/C cg17346650 chr17:80929145 B3GNTL1 0.48 7.11 0.37 7.13e-12 Glycated hemoglobin levels; CRC cis rs6582630 0.555 rs7978749 chr12:38527141 G/T cg26384229 chr12:38710491 ALG10B 0.71 10.13 0.49 3.5e-21 Drug-induced liver injury (flucloxacillin); CRC cis rs1023500 0.551 rs133371 chr22:42465574 G/A cg04733989 chr22:42467013 NAGA 0.57 8.69 0.43 1.71e-16 Schizophrenia; CRC cis rs12143943 0.966 rs12038102 chr1:204551407 G/A cg17419461 chr1:204415978 PIK3C2B 0.43 6.43 0.33 4.52e-10 Cognitive performance; CRC cis rs972578 0.967 rs2413736 chr22:43338839 G/A cg01576275 chr22:43409880 NA -0.45 -7.25 -0.37 3.09e-12 Mean platelet volume; CRC trans rs1005277 0.540 rs2224248 chr10:38451886 A/G cg27523141 chr10:43048294 ZNF37B 0.49 7.13 0.37 6.4e-12 Extrinsic epigenetic age acceleration; CRC cis rs887829 0.569 rs4663963 chr2:234650193 T/G cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.46 -7.27 -0.37 2.6e-12 Metabolic traits;Bilirubin levels;Cholelithiasis-related traits in sickle cell anemia;Metabolite levels;Total bilirubin levels in HIV-1 infection;Serum metabolite levels;Blood metabolite levels; CRC cis rs1153858 1.000 rs12441971 chr15:45671957 A/T cg21132104 chr15:45694354 SPATA5L1 0.59 8.56 0.43 4.47e-16 Homoarginine levels; CRC cis rs5753618 0.583 rs5749279 chr22:31854209 A/G cg22777020 chr22:31556080 RNF185 0.44 5.82 0.31 1.43e-8 Colorectal cancer; CRC cis rs6062302 0.522 rs2236503 chr20:62224595 G/A cg09650180 chr20:62225654 GMEB2 -0.5 -6.67 -0.35 1.07e-10 Glioblastoma; CRC cis rs9443189 0.570 rs485906 chr6:76300550 A/C cg01950844 chr6:76311363 SENP6 0.71 9.1 0.45 9.12e-18 Prostate cancer; CRC cis rs7192380 0.825 rs3811348 chr16:69782855 C/T cg00738113 chr16:70207722 CLEC18C 0.37 6.24 0.33 1.37e-9 Sjögren's syndrome; CRC trans rs6951245 0.872 rs77569514 chr7:1085508 G/A cg13565492 chr6:43139072 SRF -0.71 -7.25 -0.37 2.95e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC trans rs1005277 0.579 rs932538 chr10:38381314 T/C cg11292332 chr7:45801988 SEPT13 -0.35 -6.33 -0.33 7.99e-10 Extrinsic epigenetic age acceleration; CRC cis rs2180341 1.000 rs6569477 chr6:127589302 T/A cg24812749 chr6:127587940 RNF146 0.93 13.35 0.59 8.71e-33 Breast cancer; CRC cis rs1008375 1.000 rs2872959 chr4:17677163 G/A cg04450456 chr4:17643702 FAM184B -0.37 -5.94 -0.31 7.24e-9 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs9325144 0.647 rs7316392 chr12:39064381 T/G cg26384229 chr12:38710491 ALG10B -0.52 -7.39 -0.38 1.25e-12 Morning vs. evening chronotype; CRC cis rs939658 1.000 rs12439908 chr15:79456381 T/C cg17916960 chr15:79447300 NA 0.45 7.4 0.38 1.14e-12 Refractive error; CRC cis rs8064299 0.967 rs7420 chr17:72765215 A/G cg25054828 chr17:72772726 NAT9;TMEM104 -0.6 -9.38 -0.46 1.12e-18 Monocyte count; CRC trans rs274508 0.926 rs274491 chr11:11099798 A/G cg18158151 chr2:61372256 C2orf74 0.33 6.43 0.33 4.45e-10 Knee osteoarthritis; CRC cis rs873946 0.586 rs12776770 chr10:134564831 T/C cg06453172 chr10:134556979 INPP5A -0.66 -8.37 -0.42 1.63e-15 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CRC cis rs9303542 0.559 rs56038617 chr17:46612578 C/T cg04904318 chr17:46607828 HOXB1 -0.54 -6.24 -0.33 1.36e-9 Ovarian cancer;Epithelial ovarian cancer; CRC cis rs7605827 0.930 rs7577130 chr2:15527859 G/A cg19274914 chr2:15703543 NA 0.39 5.92 0.31 7.9e-9 Educational attainment (years of education); CRC cis rs889312 0.500 rs832552 chr5:56113850 A/C cg18230493 chr5:56204884 C5orf35 0.38 5.85 0.31 1.18e-8 Breast cancer;Breast cancer (early onset); CRC cis rs11724804 0.532 rs7657611 chr4:880558 G/C cg23939001 chr4:940644 TMEM175 0.73 13.65 0.6 6.56e-34 Primary biliary cholangitis;Limited cutaneous systemic scleroderma; CRC trans rs17192198 0.661 rs73198557 chr12:90076293 G/T cg17836913 chr1:54723679 SSBP3 -0.46 -6.02 -0.31 4.59e-9 Diastolic blood pressure; CRC trans rs1941687 0.509 rs6507060 chr18:31322278 C/T cg27147174 chr7:100797783 AP1S1 0.41 6.83 0.35 4.06e-11 Subjective well-being (multi-trait analysis);Subjective well-being; CRC cis rs1055129 0.655 rs8067076 chr17:73837142 G/T cg17515076 chr17:73810948 UNK 0.39 6.19 0.32 1.74e-9 White matter hyperintensity burden; CRC cis rs7208859 0.623 rs73269916 chr17:29096326 A/G cg13385521 chr17:29058706 SUZ12P 0.73 8.35 0.42 1.93e-15 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs9649213 0.593 rs12672092 chr7:97986557 C/A cg24562669 chr7:97807699 LMTK2 0.44 7.32 0.37 1.97e-12 Prostate cancer (SNP x SNP interaction); CRC cis rs5753618 0.583 rs7285619 chr22:31842554 C/T cg22777020 chr22:31556080 RNF185 0.49 5.93 0.31 7.6e-9 Colorectal cancer; CRC cis rs2952156 0.920 rs11078919 chr17:37835755 T/C cg07936489 chr17:37558343 FBXL20 -0.4 -5.72 -0.3 2.36e-8 Asthma; CRC cis rs7618915 0.571 rs2289249 chr3:52597664 G/A cg05573699 chr3:52720067 GNL3;PBRM1 -0.44 -6.23 -0.32 1.44e-9 Bipolar disorder; CRC cis rs4555082 0.834 rs2816653 chr14:105713973 A/G cg13114125 chr14:105738426 BRF1 -0.77 -11.49 -0.54 6.25e-26 Mean platelet volume;Platelet distribution width; CRC cis rs4689388 0.926 rs4689394 chr4:6291003 C/G cg14416269 chr4:6271139 WFS1 -0.41 -6.83 -0.35 4.06e-11 Type 2 diabetes and other traits;Type 2 diabetes; CRC cis rs7772486 0.686 rs1569540 chr6:146069112 A/G cg13319975 chr6:146136371 FBXO30 0.43 6.48 0.34 3.33e-10 Lobe attachment (rater-scored or self-reported); CRC cis rs12220238 1.000 rs12358614 chr10:75906173 C/T cg19889307 chr10:75911429 ADK;AP3M1 0.62 5.98 0.31 5.74e-9 Soluble interleukin-2 receptor subunit alpha; CRC cis rs1552244 0.554 rs55847233 chr3:9991101 C/G cg00166722 chr3:10149974 C3orf24 0.39 6.03 0.32 4.29e-9 Alzheimer's disease; CRC trans rs1814175 0.817 rs7946556 chr11:49944874 G/A cg03929089 chr4:120376271 NA -0.94 -17.84 -0.7 2.9e-50 Height; CRC cis rs763121 0.853 rs6519119 chr22:38989007 C/G cg06022373 chr22:39101656 GTPBP1 0.75 11.11 0.52 1.44e-24 Menopause (age at onset); CRC cis rs4363385 0.720 rs1984197 chr1:152962915 C/G cg25856811 chr1:152973957 SPRR3 -0.26 -7.27 -0.37 2.62e-12 Inflammatory skin disease; CRC cis rs67478160 0.679 rs8011109 chr14:104279974 G/A cg08213375 chr14:104286397 PPP1R13B 0.62 12.96 0.58 2.67e-31 Schizophrenia; CRC cis rs7044106 0.734 rs10491784 chr9:123432289 A/C cg09419670 chr9:123605666 PSMD5;LOC253039 0.7 11.43 0.53 1.04e-25 Hip circumference adjusted for BMI; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg00347280 chr1:45477834 HECTD3;UROD 0.44 6.13 0.32 2.52e-9 Response to antipsychotic treatment; CRC cis rs35264875 1.000 rs72928644 chr11:68849845 A/G cg23740940 chr11:68924746 NA 0.44 5.75 0.3 2.04e-8 Blond vs. brown hair color; CRC cis rs911555 0.723 rs6575986 chr14:103886671 G/A cg12935359 chr14:103987150 CKB -0.56 -9.0 -0.44 1.9e-17 Intelligence (multi-trait analysis); CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg27339505 chr5:140998609 DIAPH1 0.51 6.95 0.36 1.91e-11 Anxiety disorder; CRC cis rs12692738 0.526 rs355867 chr2:165631057 C/T cg03182029 chr2:165697222 COBLL1 0.51 6.07 0.32 3.46e-9 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);Waist-to-hip ratio adjusted for BMI in non-smokers;Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction);Waist-to-hip ratio adjusted for body mass index; CRC cis rs34779708 0.931 rs2384283 chr10:35326789 G/A cg03585969 chr10:35415529 CREM 0.67 8.84 0.44 6.12e-17 Inflammatory bowel disease;Crohn's disease; CRC cis rs6546550 0.935 rs10202159 chr2:70062454 G/T cg02498382 chr2:70120550 SNRNP27 -0.48 -7.79 -0.39 9.04e-14 Prevalent atrial fibrillation; CRC trans rs66887589 0.616 rs11098498 chr4:120187119 T/C cg25214090 chr10:38739885 LOC399744 0.39 6.04 0.32 4.16e-9 Diastolic blood pressure; CRC cis rs1320333 0.772 rs17786111 chr2:700562 C/T cg00500140 chr2:691012 NA 0.58 6.69 0.35 9.39e-11 Obesity-related traits; CRC cis rs6951245 1.000 rs75016635 chr7:1094121 G/A cg21664854 chr7:1097933 C7orf50;GPR146 0.77 8.73 0.43 1.34e-16 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs4481887 0.927 rs4453081 chr1:248475691 C/G cg00666640 chr1:248458726 OR2T12 0.44 7.63 0.39 2.59e-13 Common traits (Other); CRC cis rs720844 0.684 rs13008203 chr2:149301897 C/A cg09247360 chr2:149335327 NA -0.58 -6.02 -0.32 4.55e-9 Peripheral arterial disease (traffic-related air pollution interaction); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg09423610 chr7:902986 UNC84A -0.38 -6.35 -0.33 6.98e-10 Liver disease severity in Alagille syndrome; CRC trans rs925098 0.577 rs2724470 chr4:17996046 A/G cg25152348 chr22:50946712 NCAPH2;LMF2 -0.42 -6.19 -0.32 1.79e-9 Birth weight;Height; CRC cis rs2842992 0.768 rs2273824 chr6:160211445 C/T cg11366901 chr6:160182831 ACAT2 0.73 10.9 0.52 8.07e-24 Age-related macular degeneration (geographic atrophy); CRC trans rs57221529 0.766 rs72703042 chr5:579269 C/T cg11887960 chr12:57824829 NA 0.62 6.76 0.35 6.26e-11 Lung disease severity in cystic fibrosis; CRC cis rs9611565 0.694 rs5758365 chr22:41858657 A/G cg06634786 chr22:41940651 POLR3H 0.66 7.79 0.39 8.63e-14 Vitiligo; CRC cis rs4713118 0.547 rs2116981 chr6:28067951 T/G cg23161317 chr6:28129485 ZNF389 0.52 6.38 0.33 6.1e-10 Parkinson's disease; CRC cis rs4805272 0.539 rs1422212 chr19:29330191 T/A cg12756686 chr19:29218302 NA 0.5 6.45 0.33 4.04e-10 Plasma omega-3 polyunsaturated fatty acid levels (docosahexaenoic acid); CRC cis rs6502050 0.835 rs7406220 chr17:80077850 T/C cg11859384 chr17:80120422 CCDC57 0.37 5.77 0.3 1.85e-8 Life satisfaction; CRC cis rs1865760 0.613 rs9295674 chr6:25912342 A/G cg16482183 chr6:26056742 HIST1H1C 0.42 6.13 0.32 2.49e-9 Height; CRC cis rs4563143 0.634 rs113736470 chr19:29240125 G/A cg04546413 chr19:29218101 NA 0.41 6.41 0.33 5.01e-10 Methadone dose in opioid dependence; CRC cis rs9549367 0.737 rs11619691 chr13:113904636 T/C cg18105134 chr13:113819100 PROZ -0.74 -10.54 -0.5 1.38e-22 Platelet distribution width; CRC cis rs2522056 0.808 rs17771891 chr5:131744202 A/G cg24060327 chr5:131705240 SLC22A5 -0.52 -6.99 -0.36 1.51e-11 Lymphocyte counts;Fibrinogen; CRC cis rs3824867 0.738 rs1228024 chr11:47951353 C/A cg05585544 chr11:47624801 NA -0.42 -7.11 -0.37 7.21e-12 Mean corpuscular hemoglobin; CRC trans rs7618501 0.633 rs6446189 chr3:50008566 A/G cg21665057 chr3:196295764 WDR53;FBXO45 0.61 9.77 0.47 5.59e-20 Intelligence (multi-trait analysis); CRC cis rs4689388 0.889 rs4629534 chr4:6294124 G/T cg00701064 chr4:6280414 WFS1 0.76 13.28 0.59 1.65e-32 Type 2 diabetes and other traits;Type 2 diabetes; CRC trans rs7395662 0.927 rs8188938 chr11:48690866 C/T cg21153622 chr11:89784906 NA 0.44 7.09 0.36 8.39e-12 HDL cholesterol; CRC cis rs34779708 0.966 rs2045915 chr10:35418616 G/C cg03585969 chr10:35415529 CREM 0.56 7.55 0.38 4.32e-13 Inflammatory bowel disease;Crohn's disease; CRC cis rs61008539 0.586 rs6959154 chr7:856320 C/T cg00475322 chr7:917719 C7orf20 0.42 7.43 0.38 9.54e-13 Perceived unattractiveness to mosquitoes; CRC cis rs7927592 0.913 rs10896329 chr11:68250029 A/G cg01657329 chr11:68192670 LRP5 -0.45 -6.42 -0.33 4.63e-10 Total body bone mineral density; CRC cis rs7221595 0.877 rs7219437 chr17:4050138 A/G cg11204139 chr17:3907470 NA 0.47 6.53 0.34 2.48e-10 Functional impairment in major depressive disorder, bipolar disorder and schizophrenia; CRC cis rs13161895 0.941 rs6876648 chr5:179441842 T/C cg02702477 chr5:179499311 RNF130 -0.55 -6.34 -0.33 7.5e-10 LDL cholesterol; CRC cis rs2153535 0.580 rs4140586 chr6:8503192 A/G cg07606381 chr6:8435919 SLC35B3 0.67 10.75 0.51 2.69e-23 Motion sickness; CRC cis rs11122272 0.735 rs2491405 chr1:231513431 C/A cg06096015 chr1:231504339 EGLN1 0.4 5.95 0.31 6.7e-9 Hemoglobin concentration; CRC cis rs6952808 0.630 rs10239050 chr7:2158390 A/G cg04267008 chr7:1944627 MAD1L1 -0.59 -8.19 -0.41 5.78e-15 Bipolar disorder and schizophrenia; CRC cis rs1003719 0.788 rs60447195 chr21:38448600 A/T cg10648535 chr21:38446584 PIGP;TTC3 0.53 7.53 0.38 4.88e-13 Eye color traits; CRC cis rs7927771 0.864 rs3781626 chr11:47442893 A/T cg18512352 chr11:47633146 NA -0.36 -7.12 -0.37 6.85e-12 Subjective well-being; CRC cis rs11758351 1.000 rs77961951 chr6:26186075 A/G cg08260959 chr6:26240920 HIST1H4F -0.41 -6.0 -0.31 5.2e-9 Gout;Renal underexcretion gout; CRC cis rs875971 0.516 rs6945322 chr7:65336056 T/C cg18876405 chr7:65276391 NA 0.65 11.91 0.55 1.97e-27 Aortic root size; CRC cis rs11212617 0.967 rs7118967 chr11:108057856 G/A cg14761454 chr11:108092087 ATM;NPAT 0.4 5.96 0.31 6.59e-9 Response to metformin in type 2 diabetes (glycemic); CRC cis rs754466 0.706 rs7099526 chr10:79657705 C/G cg17075019 chr10:79541650 NA -0.78 -12.01 -0.55 8.7300000000000009e-28 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs875971 1.000 rs1565531 chr7:65663113 T/A cg18876405 chr7:65276391 NA -0.54 -9.47 -0.46 5.74e-19 Aortic root size; CRC trans rs60843830 1.000 rs4497901 chr2:239969 C/T cg11347411 chr7:150020925 ACTR3C;LRRC61 0.58 9.17 0.45 5.42e-18 Spherical equivalent (joint analysis main effects and education interaction); CRC cis rs1448094 0.967 rs10047659 chr12:86338278 C/A cg02569458 chr12:86230093 RASSF9 0.38 6.57 0.34 1.99e-10 Major depressive disorder; CRC cis rs9914988 0.887 rs2070265 chr17:27075423 A/G cg12682573 chr17:27188876 MIR451;MIR144 -0.57 -8.17 -0.41 6.6e-15 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs11971779 0.616 rs2883772 chr7:139072756 T/C cg07862535 chr7:139043722 LUC7L2 0.57 7.35 0.38 1.61e-12 Diisocyanate-induced asthma; CRC cis rs6738825 0.565 rs17787829 chr2:198419798 T/C cg10820045 chr2:198174542 NA 0.32 5.69 0.3 2.88e-8 Crohn's disease; CRC cis rs514406 0.755 rs10888754 chr1:53228751 C/G cg24675658 chr1:53192096 ZYG11B 0.58 9.1 0.45 9.03e-18 Monocyte count; CRC cis rs9584850 0.794 rs72655609 chr13:99128622 C/G cg07423050 chr13:99094983 FARP1 0.44 6.01 0.31 4.97e-9 Neuroticism; CRC cis rs35306767 0.859 rs11817793 chr10:878895 C/T cg20503657 chr10:835505 NA 0.9 11.05 0.52 2.39e-24 Eosinophil percentage of granulocytes; CRC cis rs11971779 0.680 rs10085901 chr7:139108989 G/A cg23387468 chr7:139079360 LUC7L2 0.41 7.05 0.36 1.04e-11 Diisocyanate-induced asthma; CRC cis rs6952808 0.929 rs12699483 chr7:1975624 C/G cg04267008 chr7:1944627 MAD1L1 -0.74 -10.07 -0.49 5.62e-21 Bipolar disorder and schizophrenia; CRC cis rs7809950 0.911 rs1015411 chr7:107135612 C/T cg23024343 chr7:107201750 COG5 -0.61 -8.56 -0.43 4.46e-16 Coronary artery disease; CRC trans rs2303319 0.504 rs72877343 chr2:162607487 A/C cg23247704 chr1:116518985 SLC22A15 -0.72 -6.14 -0.32 2.42e-9 Cognitive function; CRC cis rs4073582 0.595 rs9326370 chr11:65992008 A/G cg16950941 chr11:66035639 RAB1B 0.68 11.78 0.54 5.72e-27 Gout; CRC cis rs601339 1.000 rs630408 chr12:123172822 C/T cg22192744 chr12:123187474 GPR109A -0.4 -5.67 -0.3 3.16e-8 Adiponectin levels; CRC cis rs1499614 1.000 rs60326618 chr7:66166358 G/A cg18252515 chr7:66147081 NA -1.24 -14.6 -0.63 1.48e-37 Gout; CRC cis rs4285028 0.948 rs1920290 chr3:121672305 A/G cg11130432 chr3:121712080 ILDR1 -0.52 -6.75 -0.35 6.81e-11 Multiple sclerosis; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg19970200 chr7:47621223 NA 0.44 6.58 0.34 1.86e-10 Response to antipsychotic treatment; CRC cis rs2243480 1.000 rs68189316 chr7:65409169 C/G cg12463550 chr7:65579703 CRCP 0.62 5.95 0.31 6.68e-9 Diabetic kidney disease; CRC cis rs1448094 0.512 rs6539927 chr12:86244486 T/C cg18827107 chr12:86230957 RASSF9 -0.45 -7.41 -0.38 1.1e-12 Major depressive disorder; CRC cis rs4601821 0.965 rs10891543 chr11:113255895 A/G cg14159747 chr11:113255604 NA 0.51 9.65 0.47 1.48e-19 Alcoholic chronic pancreatitis; CRC cis rs7193541 0.965 rs7184423 chr16:74709737 C/A cg01733217 chr16:74700730 RFWD3 0.85 14.85 0.63 1.58e-38 Multiple myeloma; CRC cis rs6540556 0.723 rs6702301 chr1:209923154 C/T cg23920097 chr1:209922102 NA -0.52 -6.53 -0.34 2.55e-10 Red blood cell count; CRC cis rs17490626 0.568 rs12413529 chr10:71211644 G/T cg12610070 chr10:71211762 TSPAN15 -0.42 -7.59 -0.39 3.32e-13 Thrombosis; CRC cis rs858239 0.863 rs274054 chr7:23390467 G/C cg00469287 chr7:23338798 C7orf30 0.48 6.38 0.33 5.84e-10 Cerebrospinal fluid biomarker levels; CRC cis rs225245 0.791 rs7406966 chr17:34013636 A/C cg05299278 chr17:33885742 SLFN14 0.5 8.13 0.41 8.83e-15 Reticulocyte count;Reticulocyte fraction of red cells;High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells; CRC cis rs6951245 0.678 rs28600085 chr7:1169636 C/T cg18402987 chr7:1209562 NA 0.67 7.75 0.39 1.15e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs28386778 0.897 rs2854221 chr17:61941445 G/T cg06873352 chr17:61820015 STRADA 0.73 13.55 0.6 1.54e-33 Prudent dietary pattern; CRC cis rs13256369 0.901 rs12681298 chr8:8566235 A/G cg06671706 chr8:8559999 CLDN23 -0.55 -8.53 -0.43 5.61e-16 Obesity-related traits; CRC cis rs60843830 0.508 rs300750 chr2:208794 T/G cg00108164 chr2:264199 ACP1;SH3YL1 0.46 6.99 0.36 1.53e-11 Spherical equivalent (joint analysis main effects and education interaction); CRC cis rs7940866 0.874 rs10894290 chr11:130811049 T/G cg12179176 chr11:130786555 SNX19 0.57 8.47 0.42 8.34e-16 Schizophrenia; CRC cis rs1552244 1.000 rs6442146 chr3:10073544 C/T cg00166722 chr3:10149974 C3orf24 0.66 9.01 0.45 1.66e-17 Alzheimer's disease; CRC cis rs2386661 0.826 rs1317516 chr10:5672720 A/G cg26603656 chr10:5671107 NA -0.54 -8.38 -0.42 1.57e-15 Breast cancer; CRC trans rs10242455 1.000 rs1859690 chr7:99227172 A/G cg09045935 chr12:6379348 NA 0.61 6.72 0.35 7.84e-11 Blood metabolite levels; CRC cis rs561341 1.000 rs501312 chr17:30329066 A/G cg23018236 chr17:30244563 NA -0.67 -8.01 -0.4 1.96e-14 Hip circumference adjusted for BMI; CRC cis rs9487051 0.768 rs9398188 chr6:109526615 G/A cg01475377 chr6:109611718 NA -0.34 -5.91 -0.31 8.35e-9 Reticulocyte fraction of red cells; CRC cis rs7771547 0.573 rs517890 chr6:36397786 G/C cg07856975 chr6:36356162 ETV7 0.4 5.91 0.31 8.7e-9 Platelet distribution width; CRC cis rs4665809 0.590 rs10495756 chr2:26485586 A/G cg22920501 chr2:26401640 FAM59B 0.85 12.21 0.56 1.54e-28 Gut microbiome composition (summer); CRC cis rs1799949 0.965 rs11650913 chr17:41331597 T/C cg05368731 chr17:41323189 NBR1 0.67 9.93 0.48 1.65e-20 Menopause (age at onset); CRC cis rs34172651 0.517 rs11647120 chr16:24819806 A/G cg06028605 chr16:24865363 SLC5A11 0.58 9.63 0.47 1.69e-19 Intelligence (multi-trait analysis); CRC cis rs2067615 0.524 rs10778503 chr12:107090616 C/T cg13491945 chr12:107078410 RFX4 0.37 6.3 0.33 9.59e-10 Heart rate; CRC cis rs11122272 0.735 rs11122281 chr1:231519842 A/G cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.54 -8.09 -0.41 1.18e-14 Hemoglobin concentration; CRC cis rs40363 0.723 rs757269 chr16:3538003 A/G cg00484396 chr16:3507460 NAT15 -0.62 -6.48 -0.34 3.37e-10 Tuberculosis; CRC cis rs6695223 0.571 rs4907133 chr1:85538947 A/G cg11262906 chr1:85462892 MCOLN2 -0.48 -6.11 -0.32 2.85e-9 Venous thromboembolism (SNP x SNP interaction); CRC cis rs9560113 1.000 rs9560103 chr13:112174253 G/A cg10483660 chr13:112241077 NA 0.35 5.65 0.3 3.57e-8 Menarche (age at onset); CRC cis rs13108904 0.518 rs4974602 chr4:1342391 C/T cg20092199 chr4:1342459 KIAA1530 0.47 7.71 0.39 1.5e-13 Obesity-related traits; CRC cis rs6754311 0.689 rs192822 chr2:136682274 A/T cg15123519 chr2:136567270 LCT -0.3 -5.76 -0.3 1.96e-8 Mosquito bite size; CRC cis rs17376456 0.825 rs6865441 chr5:93284746 G/A cg21475434 chr5:93447410 FAM172A 0.82 7.76 0.39 1.07e-13 Diabetic retinopathy; CRC cis rs8044995 0.501 rs55793998 chr16:68378985 G/T cg05110241 chr16:68378359 PRMT7 -0.76 -7.96 -0.4 2.88e-14 Schizophrenia; CRC cis rs9814567 0.752 rs9848254 chr3:134330374 T/G cg06109529 chr3:134205091 CEP63;ANAPC13 -0.67 -9.58 -0.47 2.53e-19 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs10971721 0.822 rs10971723 chr9:33829602 A/G cg13495928 chr9:33750294 PRSS3 0.55 5.93 0.31 7.7e-9 Body mass index; CRC cis rs9322193 0.962 rs9322219 chr6:150103399 C/T cg05861140 chr6:150128134 PCMT1 -0.4 -6.58 -0.34 1.82e-10 Lung cancer; CRC cis rs4242434 0.927 rs57594397 chr8:22475657 T/C cg03733263 chr8:22462867 KIAA1967 1.04 18.63 0.72 2.21e-53 Exploratory eye movement dysfunction in schizophrenia (cognitive search score); CRC cis rs10791323 0.519 rs329663 chr11:133754543 A/G cg06766960 chr11:133703094 NA -0.34 -6.14 -0.32 2.43e-9 Childhood ear infection; CRC cis rs4523957 0.928 rs7213232 chr17:2165340 A/G cg16513277 chr17:2031491 SMG6 -0.56 -9.37 -0.46 1.18e-18 Autism spectrum disorder or schizophrenia;Schizophrenia; CRC cis rs12200560 0.505 rs211171 chr6:97070579 T/G cg06623918 chr6:96969491 KIAA0776 0.48 7.0 0.36 1.42e-11 Coronary heart disease; CRC trans rs61931739 0.500 rs10772163 chr12:34532950 T/C cg26384229 chr12:38710491 ALG10B 0.59 8.77 0.44 9.64e-17 Morning vs. evening chronotype; CRC cis rs6860806 0.507 rs270606 chr5:131650867 A/G cg04518342 chr5:131593106 PDLIM4 0.46 7.31 0.37 2.06e-12 Breast cancer; CRC cis rs7074356 0.523 rs7087728 chr10:82033470 G/A cg27171509 chr10:82033454 MAT1A -0.47 -8.53 -0.43 5.25e-16 Borderline personality disorder; CRC cis rs853679 0.527 rs707907 chr6:28291240 A/G cg21251018 chr6:28226885 NKAPL 0.52 8.68 0.43 1.92e-16 Depression; CRC cis rs644799 1.000 rs12786522 chr11:95522858 G/C cg25478527 chr11:95522999 CEP57;FAM76B 0.52 7.75 0.39 1.19e-13 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs3091242 0.933 rs9438904 chr1:25756860 T/C cg20684491 chr1:25596433 NA 0.42 7.35 0.38 1.57e-12 Erythrocyte sedimentation rate; CRC cis rs9467603 0.547 rs7752195 chr6:25419094 A/G cg16898833 chr6:26189333 HIST1H4D -0.79 -6.31 -0.33 8.79e-10 Intelligence (multi-trait analysis); CRC cis rs1862618 0.853 rs6450408 chr5:56098146 T/C cg20203395 chr5:56204925 C5orf35 -0.72 -8.56 -0.43 4.42e-16 Initial pursuit acceleration; CRC cis rs7259376 0.936 rs16999064 chr19:22552602 A/G cg02657401 chr19:22469223 NA -0.32 -6.96 -0.36 1.87e-11 Menopause (age at onset); CRC cis rs2976388 0.590 rs3758082 chr8:143824483 A/G cg24634471 chr8:143751801 JRK -0.45 -6.41 -0.33 5.18e-10 Urinary tract infection frequency; CRC cis rs2160860 0.773 rs55698142 chr8:39796429 T/C cg11363097 chr8:39792086 IDO2 -0.43 -7.29 -0.37 2.33e-12 Blood metabolite levels; CRC cis rs8177179 0.967 rs6439434 chr3:133450371 T/G cg24879335 chr3:133465180 TF 0.49 9.67 0.47 1.26e-19 Iron status biomarkers (transferrin levels); CRC cis rs9875589 0.509 rs9867041 chr3:14014615 T/C cg14375111 chr3:14165186 TMEM43;CHCHD4 0.4 6.22 0.32 1.53e-9 Ovarian reserve; CRC trans rs1814175 0.645 rs1851869 chr11:49960552 T/C cg03929089 chr4:120376271 NA -0.91 -16.17 -0.67 1.06e-43 Height; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg22520562 chr4:82392859 RASGEF1B 0.36 6.14 0.32 2.4e-9 Liver disease severity in Alagille syndrome; CRC cis rs28386778 0.897 rs2727333 chr17:61876023 G/A cg23090583 chr17:61904693 PSMC5;FTSJ3 1.05 20.56 0.75 5.27e-61 Prudent dietary pattern; CRC cis rs11249608 0.548 rs11958355 chr5:178451640 T/C cg01312482 chr5:178451176 ZNF879 -0.37 -6.15 -0.32 2.26e-9 Pubertal anthropometrics; CRC cis rs10504229 0.683 rs17194487 chr8:58104912 C/T cg21724239 chr8:58056113 NA 0.75 9.31 0.46 1.82e-18 Developmental language disorder (linguistic errors); CRC cis rs4803468 1.000 rs3816037 chr19:41918009 C/T cg09537434 chr19:41945824 ATP5SL -0.91 -17.83 -0.7 3.11e-50 Height; CRC cis rs7119 0.604 rs907383 chr15:77870646 A/G cg27398640 chr15:77910606 LINGO1 0.44 7.5 0.38 5.82e-13 Type 2 diabetes; CRC cis rs2243480 0.901 rs35823062 chr7:65965821 A/G cg18252515 chr7:66147081 NA -1.29 -15.43 -0.65 8.93e-41 Diabetic kidney disease; CRC cis rs6582630 0.519 rs11495373 chr12:38275470 T/C cg26384229 chr12:38710491 ALG10B 0.66 8.94 0.44 2.88e-17 Drug-induced liver injury (flucloxacillin); CRC cis rs2594714 0.538 rs895819 chr19:13947292 A/G cg18576835 chr19:13944261 NA -0.45 -6.43 -0.33 4.52e-10 Breast cancer; CRC cis rs10504229 1.000 rs56350499 chr8:58178139 C/T cg02290350 chr8:58132656 NA -0.42 -5.96 -0.31 6.62e-9 Developmental language disorder (linguistic errors); CRC cis rs11785400 1.000 rs4297023 chr8:143733307 C/A cg24634471 chr8:143751801 JRK 0.53 7.58 0.39 3.48e-13 Schizophrenia; CRC cis rs9318086 0.663 rs2312295 chr13:24457744 A/T cg25267304 chr13:24462978 PCOTH;MIPEP 0.64 10.31 0.49 9.09e-22 Myopia (pathological); CRC trans rs2797160 1.000 rs1832979 chr6:125997436 A/G cg05039488 chr6:79577232 IRAK1BP1 -0.52 -7.61 -0.39 2.88e-13 Endometrial cancer; CRC cis rs2408955 0.521 rs7301003 chr12:48550227 A/G cg15465823 chr12:48382534 COL2A1 0.38 6.31 0.33 8.92e-10 Glycated hemoglobin levels; CRC cis rs9393692 0.905 rs9379838 chr6:26277133 C/T cg00631329 chr6:26305371 NA -0.69 -13.41 -0.59 4.96e-33 Educational attainment; CRC trans rs17685 0.753 rs6464999 chr7:75787315 T/C cg19862616 chr7:65841803 NCRNA00174 0.98 18.08 0.71 3.12e-51 Coffee consumption;Coffee consumption (cups per day); CRC cis rs17270561 0.609 rs4711096 chr6:25727054 A/G cg16482183 chr6:26056742 HIST1H1C 0.81 10.35 0.5 6.29e-22 Iron status biomarkers; CRC cis rs7264396 0.570 rs1970576 chr20:34336720 C/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.63 -10.53 -0.5 1.59e-22 Total cholesterol levels; CRC cis rs10504229 0.593 rs12216730 chr8:58003894 C/T cg22535103 chr8:58192502 C8orf71 -0.49 -5.81 -0.31 1.46e-8 Developmental language disorder (linguistic errors); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg11916758 chr5:133512809 SKP1 0.4 6.65 0.34 1.25e-10 Liver disease severity in Alagille syndrome; CRC cis rs11690935 0.959 rs10204501 chr2:172588865 C/G cg13550731 chr2:172543902 DYNC1I2 -1.1 -18.59 -0.72 3.14e-53 Schizophrenia; CRC cis rs4363385 0.720 rs9325996 chr1:152965347 A/G cg25856811 chr1:152973957 SPRR3 -0.26 -7.27 -0.37 2.72e-12 Inflammatory skin disease; CRC cis rs1570884 0.516 rs2094108 chr13:50171550 G/A cg02321871 chr13:50159138 RCBTB1 -0.43 -6.15 -0.32 2.21e-9 Sum basophil neutrophil counts;Sum neutrophil eosinophil counts;Neutrophil count;Myeloid white cell count;Granulocyte count; CRC trans rs1656966 1.000 rs1656966 chr3:186466252 C/T cg16975985 chr12:49524048 TUBA1B 0.4 6.07 0.32 3.55e-9 Myopia (pathological); CRC cis rs6545883 0.525 rs1729658 chr2:61373520 C/T cg10580144 chr2:61372316 C2orf74 0.29 6.02 0.32 4.58e-9 Tuberculosis; CRC cis rs11148252 0.574 rs3742297 chr13:53278067 T/C cg02158880 chr13:53174818 NA 0.58 9.24 0.45 3.06e-18 Lewy body disease; CRC cis rs6860806 0.507 rs2631364 chr5:131706914 C/G cg07395648 chr5:131743802 NA 0.42 5.79 0.3 1.63e-8 Breast cancer; CRC cis rs910316 1.000 rs175426 chr14:75624134 C/T cg03030879 chr14:75389066 RPS6KL1 0.45 6.91 0.36 2.45e-11 Height; CRC cis rs9393813 0.516 rs4711152 chr6:27380202 C/T cg02683197 chr6:28174875 NA 0.39 5.62 0.3 3.99e-8 Bipolar disorder; CRC cis rs875971 0.660 rs62465434 chr7:66005152 A/C cg00343986 chr7:65444356 GUSB 0.49 7.42 0.38 1e-12 Aortic root size; CRC cis rs35110281 0.667 rs4819287 chr21:45120147 A/G cg01579765 chr21:45077557 HSF2BP -0.32 -5.79 -0.3 1.68e-8 Mean corpuscular volume; CRC cis rs7666738 0.830 rs13148913 chr4:99009732 C/T cg17366294 chr4:99064904 C4orf37 0.44 7.39 0.38 1.19e-12 Colonoscopy-negative controls vs population controls; CRC trans rs10982213 0.830 rs2274163 chr9:117188714 C/T cg14321424 chr11:46403087 MDK 0.39 6.0 0.31 5.26e-9 Interleukin-6 levels; CRC cis rs6540556 0.723 rs3766619 chr1:209895298 C/G cg05527609 chr1:210001259 C1orf107 -0.57 -6.29 -0.33 1.03e-9 Red blood cell count; CRC cis rs896854 0.654 rs4735339 chr8:95974373 C/T cg23172400 chr8:95962367 TP53INP1 -0.48 -8.17 -0.41 6.79e-15 Type 2 diabetes; CRC cis rs72792276 1.000 rs10519971 chr5:127379216 A/G cg25462716 chr5:127418816 SLC12A2;FLJ33630 -0.54 -5.62 -0.3 4.15e-8 Red cell distribution width; CRC cis rs4891159 0.790 rs35516239 chr18:74129942 C/T cg24786174 chr18:74118243 ZNF516 -0.89 -17.07 -0.69 3.2e-47 Longevity; CRC cis rs8177179 0.967 rs10935085 chr3:133459735 C/T cg17775713 chr3:133465469 TF 0.37 6.71 0.35 8.7e-11 Iron status biomarkers (transferrin levels); CRC cis rs72781680 0.950 rs72796402 chr2:24180104 A/G cg08917208 chr2:24149416 ATAD2B 1.04 10.13 0.49 3.61e-21 Lymphocyte counts; CRC cis rs801193 0.569 rs2659907 chr7:66164032 G/A cg11764359 chr7:65958608 NA 0.59 8.79 0.44 8.46e-17 Aortic root size; CRC cis rs4073416 0.542 rs6573616 chr14:66046816 A/G cg03016385 chr14:66212404 NA -0.46 -6.23 -0.32 1.47e-9 N-glycan levels; CRC cis rs2380220 0.541 rs72928273 chr6:96079360 C/T cg15832292 chr6:96025679 MANEA -0.6 -6.35 -0.33 7.11e-10 Behavioural disinhibition (generation interaction); CRC trans rs12599106 0.560 rs34151874 chr16:34989694 G/A cg11235426 chr6:292522 DUSP22 -0.66 -9.41 -0.46 8.63e-19 Menopause (age at onset); CRC cis rs6540556 0.954 rs6696463 chr1:209933757 G/C cg23920097 chr1:209922102 NA -0.52 -6.59 -0.34 1.72e-10 Red blood cell count; CRC cis rs7512552 0.809 rs696618 chr1:150376139 T/G cg15654264 chr1:150340011 RPRD2 0.6 8.65 0.43 2.37e-16 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); CRC cis rs7147624 0.766 rs11158597 chr14:65913536 T/G cg03016385 chr14:66212404 NA -1.06 -10.93 -0.52 6.34e-24 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs736801 0.740 rs17622378 chr5:131778452 A/G cg11843238 chr5:131593191 PDLIM4 0.33 5.71 0.3 2.49e-8 Breast cancer;Mosquito bite size; CRC cis rs9322193 0.923 rs1080670 chr6:149941297 C/G cg13206674 chr6:150067644 NUP43 0.65 9.76 0.47 6.33e-20 Lung cancer; CRC cis rs2197308 0.606 rs12314897 chr12:38392293 C/T cg26384229 chr12:38710491 ALG10B -0.52 -7.59 -0.39 3.4e-13 Morning vs. evening chronotype; CRC trans rs17685 0.712 rs56965035 chr7:75795670 G/A cg19862616 chr7:65841803 NCRNA00174 0.97 16.87 0.68 1.91e-46 Coffee consumption;Coffee consumption (cups per day); CRC cis rs67311347 0.955 rs6764102 chr3:40378153 C/G cg24209194 chr3:40518798 ZNF619 0.42 6.21 0.32 1.64e-9 Renal cell carcinoma; CRC cis rs7666738 0.800 rs10028921 chr4:98962630 G/T cg05340658 chr4:99064831 C4orf37 0.62 9.6 0.47 2.1e-19 Colonoscopy-negative controls vs population controls; CRC cis rs62064224 0.546 rs1018866 chr17:30829664 A/C cg25809561 chr17:30822961 MYO1D 0.67 12.17 0.56 2.21e-28 Schizophrenia; CRC cis rs6918586 0.658 rs13161 chr6:26114702 C/T cg18357526 chr6:26021779 HIST1H4A -0.49 -7.39 -0.38 1.21e-12 Schizophrenia; CRC cis rs2243480 1.000 rs778729 chr7:65824419 T/C cg12463550 chr7:65579703 CRCP 0.7 6.29 0.33 9.95e-10 Diabetic kidney disease; CRC cis rs28829049 0.597 rs2313509 chr1:19437860 C/T cg13387374 chr1:19411106 UBR4 0.4 5.81 0.31 1.48e-8 QRS duration in Tripanosoma cruzi seropositivity; CRC cis rs4665809 0.589 rs4665842 chr2:26448954 A/G cg04944784 chr2:26401820 FAM59B -0.83 -10.74 -0.51 2.99e-23 Gut microbiome composition (summer); CRC cis rs9393692 0.557 rs6918325 chr6:26327965 T/G cg00631329 chr6:26305371 NA -0.53 -8.71 -0.43 1.55e-16 Educational attainment; CRC cis rs11148252 0.744 rs4884354 chr13:53017474 T/C cg00495681 chr13:53174319 NA 0.58 8.54 0.43 5.13e-16 Lewy body disease; CRC cis rs6743376 0.509 rs3180234 chr2:113820655 A/T cg24553058 chr2:113831203 IL1F10 0.44 7.18 0.37 4.61e-12 Inflammatory biomarkers; CRC trans rs333332 0.961 rs333334 chr3:124328346 C/G cg08451243 chr11:1273788 MUC5B 0.41 6.5 0.34 2.9e-10 Heschl's gyrus morphology; CRC cis rs6504622 1.000 rs11079745 chr17:45044147 C/A cg16759221 chr17:45003025 GOSR2 0.47 7.46 0.38 7.87e-13 Orofacial clefts; CRC cis rs780096 0.546 rs1104 chr2:27599875 T/G cg24768116 chr2:27665128 KRTCAP3 -0.35 -7.84 -0.4 6.39e-14 Total body bone mineral density; CRC cis rs12291225 0.679 rs11238 chr11:14288128 A/C cg05501817 chr11:14380813 RRAS2 0.44 5.88 0.31 1.03e-8 Sense of smell; CRC trans rs11098499 0.863 rs1010739 chr4:120463471 C/T cg25214090 chr10:38739885 LOC399744 0.63 9.88 0.48 2.41e-20 Corneal astigmatism; CRC cis rs6534441 0.857 rs1509525 chr4:125455457 G/A cg21609808 chr4:125404261 NA 0.4 5.89 0.31 9.36e-9 Major depressive disorder; CRC cis rs853679 0.517 rs9368551 chr6:28061792 A/G cg03623178 chr6:28175578 NA 0.96 12.48 0.57 1.62e-29 Depression; CRC cis rs995000 0.931 rs1168086 chr1:63112389 A/G cg19896129 chr1:63156450 NA -0.41 -6.24 -0.33 1.38e-9 Triglyceride levels; CRC cis rs1878931 0.535 rs55732163 chr16:3411518 A/C cg26668626 chr16:3451006 ZNF174;ZNF434 -0.51 -6.2 -0.32 1.71e-9 Body mass index (adult); CRC cis rs9796 0.636 rs1983400 chr15:41373029 T/C cg18705301 chr15:41695430 NDUFAF1 -0.38 -6.42 -0.33 4.69e-10 Menopause (age at onset); CRC cis rs10504229 0.683 rs61364624 chr8:58134339 T/A cg02290350 chr8:58132656 NA -0.58 -8.16 -0.41 7.29e-15 Developmental language disorder (linguistic errors); CRC cis rs5769765 0.773 rs58375955 chr22:50312630 A/G cg02269571 chr22:50332266 NA -0.61 -7.92 -0.4 3.64e-14 Schizophrenia; CRC trans rs9409565 0.762 rs60964095 chr9:97175774 G/T cg05679027 chr9:99775184 HIATL2 -0.41 -6.18 -0.32 1.85e-9 Colorectal cancer (alcohol consumption interaction); CRC cis rs78707713 0.512 rs35793747 chr10:71182165 A/G cg12610070 chr10:71211762 TSPAN15 -0.41 -7.24 -0.37 3.1e-12 Venous thromboembolism; CRC cis rs60843830 0.661 rs7561648 chr2:105171 G/T cg00108164 chr2:264199 ACP1;SH3YL1 0.41 5.75 0.3 2.08e-8 Spherical equivalent (joint analysis main effects and education interaction); CRC cis rs7927771 0.698 rs34467936 chr11:47915299 A/G cg18512352 chr11:47633146 NA -0.45 -8.57 -0.43 4.2e-16 Subjective well-being; CRC cis rs10760158 0.800 rs10739595 chr9:124056021 T/C cg14417974 chr9:124058376 GSN -0.34 -5.75 -0.3 2.04e-8 Pulse pressure; CRC cis rs9894429 1.000 rs35435780 chr17:79579602 G/T cg18240062 chr17:79603768 NPLOC4 0.56 9.34 0.46 1.54e-18 Eye color traits; CRC cis rs600806 0.888 rs2228604 chr1:109884775 A/C cg23032129 chr1:109941072 SORT1 -0.27 -5.78 -0.3 1.73e-8 Intelligence (multi-trait analysis); CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg07590406 chr3:58292066 RPP14 0.52 6.83 0.35 4.05e-11 Thyroid stimulating hormone; CRC cis rs4819052 0.851 rs2838829 chr21:46664040 A/C cg11663144 chr21:46675770 NA -0.83 -14.39 -0.62 9.32e-37 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs4713118 0.614 rs9468209 chr6:27694421 C/T cg20933634 chr6:27740509 NA 0.39 5.81 0.31 1.46e-8 Parkinson's disease; CRC cis rs1200821 0.535 rs1208789 chr10:37722472 A/G cg00409905 chr10:38381863 ZNF37A -0.46 -6.83 -0.35 4.07e-11 Hemostatic factors and hematological phenotypes; CRC cis rs911119 0.954 rs2424582 chr20:23622550 A/G cg16589663 chr20:23618590 CST3 0.61 8.54 0.43 4.9e-16 Chronic kidney disease; CRC cis rs9322193 0.923 rs9322204 chr6:149957183 A/C cg00933542 chr6:150070202 PCMT1 0.29 5.94 0.31 7.38e-9 Lung cancer; CRC cis rs2204008 0.744 rs67889662 chr12:38327042 T/A cg26384229 chr12:38710491 ALG10B 0.67 9.0 0.44 1.84e-17 Bladder cancer; CRC cis rs6912958 1.000 rs13214153 chr6:88153983 G/C cg08069147 chr6:88032118 GJB7;C6orf162 -0.62 -9.5 -0.46 4.44e-19 Monocyte percentage of white cells; CRC cis rs2836974 0.831 rs11911149 chr21:40528375 C/T cg11890956 chr21:40555474 PSMG1 1.1 21.19 0.76 1.86e-63 Cognitive function; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg21900616 chr22:20286845 NA 0.44 6.28 0.33 1.09e-9 Response to antipsychotic treatment; CRC cis rs231513 0.954 rs231514 chr17:41964516 C/T cg16892393 chr17:41919603 NA -0.53 -5.78 -0.3 1.71e-8 Cognitive function; CRC cis rs9399135 0.967 rs2297340 chr6:135376058 T/C cg22676075 chr6:135203613 NA 0.39 6.07 0.32 3.51e-9 Red blood cell count; CRC cis rs9814567 0.963 rs9844537 chr3:134238341 G/A cg06109529 chr3:134205091 CEP63;ANAPC13 -0.81 -12.02 -0.55 8.05e-28 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs35306767 0.903 rs11816064 chr10:931176 A/C cg20503657 chr10:835505 NA 0.95 11.98 0.55 1.09e-27 Eosinophil percentage of granulocytes; CRC cis rs1862618 0.853 rs832584 chr5:56179212 A/G cg20203395 chr5:56204925 C5orf35 0.65 8.18 0.41 6.33e-15 Initial pursuit acceleration; CRC cis rs10833965 0.748 rs10833979 chr11:23232089 C/T cg16745844 chr11:23258850 NA 0.36 5.68 0.3 2.93e-8 Cancer; CRC cis rs3764400 0.567 rs36071506 chr17:46279772 C/T cg10706073 chr17:46328419 SKAP1 -0.61 -6.75 -0.35 6.66e-11 Body mass index; CRC cis rs3806843 0.548 rs246056 chr5:140325600 G/A cg19875535 chr5:140030758 IK 0.39 6.02 0.31 4.67e-9 Depressive symptoms (multi-trait analysis); CRC cis rs3741404 0.620 rs12787945 chr11:63977546 G/A cg15107132 chr11:63991130 FERMT3 -0.39 -6.36 -0.33 6.95e-10 Platelet count; CRC cis rs7258465 0.965 rs10409003 chr19:18543054 C/T cg06462663 chr19:18546047 ISYNA1 0.49 7.11 0.36 7.23e-12 Breast cancer; CRC cis rs1552244 0.515 rs67342818 chr3:10166406 G/A cg16606324 chr3:10149918 C3orf24 0.66 7.74 0.39 1.19e-13 Alzheimer's disease; CRC cis rs3018066 0.666 rs13534 chr4:107270027 G/A cg01869342 chr4:106983673 TBCK 0.47 6.05 0.32 3.85e-9 Cancer; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg10800003 chr3:169940158 PRKCI 0.45 6.65 0.34 1.2e-10 Intelligence (multi-trait analysis); CRC cis rs10504229 1.000 rs17805602 chr8:58179915 A/G cg24829409 chr8:58192753 C8orf71 -0.68 -11.34 -0.53 2.27e-25 Developmental language disorder (linguistic errors); CRC cis rs10504229 1.000 rs66477954 chr8:58187810 C/T cg22535103 chr8:58192502 C8orf71 -0.82 -12.27 -0.56 9.63e-29 Developmental language disorder (linguistic errors); CRC cis rs561341 0.714 rs547473 chr17:30297560 T/G cg19193384 chr17:30244184 NA -0.53 -6.66 -0.34 1.15e-10 Hip circumference adjusted for BMI; CRC cis rs7824557 0.564 rs13274106 chr8:11233958 A/G cg08071915 chr8:12219732 FAM66A 0.34 6.16 0.32 2.12e-9 Retinal vascular caliber; CRC cis rs738322 0.646 rs132972 chr22:38562056 T/C cg03162506 chr22:38580953 NA 0.26 5.62 0.3 4.15e-8 Cutaneous nevi; CRC cis rs6570726 0.935 rs9390329 chr6:145828026 T/C cg05347473 chr6:146136440 FBXO30 0.36 5.7 0.3 2.73e-8 Lobe attachment (rater-scored or self-reported); CRC cis rs5769707 0.609 rs135861 chr22:49998118 A/G cg20744362 chr22:50050164 C22orf34 0.34 6.32 0.33 8.57e-10 Monocyte count;Monocyte percentage of white cells; CRC cis rs7071206 0.947 rs10509391 chr10:79422369 G/A cg07817648 chr10:79422355 NA -0.72 -9.25 -0.45 3.03e-18 Bone mineral density; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg11643463 chr12:93323276 EEA1 0.44 6.2 0.32 1.71e-9 Anxiety disorder; CRC trans rs1908814 0.516 rs35391955 chr8:11796728 A/C cg06636001 chr8:8085503 FLJ10661 0.48 7.08 0.36 8.64e-12 Neuroticism; CRC cis rs2270875 1.000 rs76695849 chr8:132926989 A/G cg24184792 chr8:132919238 EFR3A -0.69 -6.99 -0.36 1.55e-11 Response to cholinesterase inhibitors in Alzheimer's disease; CRC cis rs4780401 0.933 rs4439779 chr16:11826841 A/G cg01061890 chr16:11836724 TXNDC11 -0.41 -5.69 -0.3 2.75e-8 Rheumatoid arthritis; CRC cis rs2949837 0.581 rs2965068 chr7:45974375 T/C cg21268650 chr7:45961089 IGFBP3 0.36 6.27 0.33 1.16e-9 Sitting height ratio; CRC cis rs2576037 0.899 rs2060417 chr18:44576486 C/A cg20875182 chr18:44561130 TCEB3B;KATNAL2 -0.47 -7.23 -0.37 3.4e-12 Personality dimensions; CRC cis rs868943 0.582 rs12210252 chr6:116477493 G/T cg15226275 chr6:116381976 FRK -0.24 -5.63 -0.3 3.8e-8 Total cholesterol levels; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg18743068 chr10:94831650 NA 0.46 7.38 0.38 1.29e-12 Intelligence (multi-trait analysis); CRC trans rs17270561 0.609 rs1179086 chr6:25791745 A/T cg02936872 chr9:99801550 CTSL2 0.48 6.18 0.32 1.85e-9 Iron status biomarkers; CRC cis rs4285028 0.696 rs3915060 chr3:121712980 C/T cg20356878 chr3:121714668 ILDR1 0.52 7.65 0.39 2.25e-13 Multiple sclerosis; CRC cis rs7044106 0.762 rs10760107 chr9:123383630 T/C cg14255062 chr9:123606675 PSMD5;LOC253039 0.42 6.13 0.32 2.57e-9 Hip circumference adjusted for BMI; CRC trans rs4698169 0.510 rs675984 chr4:17123821 A/G cg01866215 chr16:3150293 NA -0.71 -6.27 -0.33 1.11e-9 Temperament (bipolar disorder); CRC cis rs1555895 0.576 rs10904571 chr10:850762 A/G cg10556349 chr10:835070 NA -0.35 -6.76 -0.35 6.32e-11 Survival in rectal cancer; CRC cis rs6604026 0.922 rs12746956 chr1:93312142 A/G cg22128645 chr1:93425802 FAM69A -0.39 -5.72 -0.3 2.36e-8 Multiple sclerosis; CRC cis rs3008870 1.000 rs7511948 chr1:67430427 A/G cg08660285 chr1:67390436 MIER1;WDR78 1.03 15.22 0.64 5.89e-40 Lymphocyte percentage of white cells; CRC cis rs6952808 0.823 rs10950448 chr7:1966492 G/C cg04267008 chr7:1944627 MAD1L1 -0.82 -11.79 -0.55 5.22e-27 Bipolar disorder and schizophrenia; CRC cis rs3789045 0.826 rs55979051 chr1:204567041 A/G cg17419461 chr1:204415978 PIK3C2B -0.52 -7.31 -0.37 2.09e-12 Educational attainment (college completion); CRC trans rs1941687 0.563 rs1565784 chr18:31358491 G/T cg27147174 chr7:100797783 AP1S1 0.35 6.12 0.32 2.72e-9 Subjective well-being (multi-trait analysis);Subjective well-being; CRC trans rs3942852 0.774 rs10838811 chr11:48186795 A/G cg03929089 chr4:120376271 NA -0.72 -9.02 -0.45 1.64e-17 Acute lymphoblastic leukemia (childhood); CRC cis rs9914988 0.560 rs8066347 chr17:27244473 G/A cg16670446 chr17:27188758 MIR451;MIR144 0.5 6.36 0.33 6.69e-10 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs875971 0.830 rs427575 chr7:65519219 A/G cg12463550 chr7:65579703 CRCP 0.46 6.46 0.34 3.81e-10 Aortic root size; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg26291818 chr8:61429582 RAB2A 0.39 6.43 0.33 4.44e-10 Liver disease severity in Alagille syndrome; CRC cis rs10504229 1.000 rs61998258 chr8:58192284 T/C cg01721255 chr8:58191610 C8orf71 0.49 6.17 0.32 2e-9 Developmental language disorder (linguistic errors); CRC cis rs17253792 0.822 rs77250916 chr14:56042208 A/G cg01858014 chr14:56050164 KTN1 -0.88 -6.9 -0.36 2.63e-11 Putamen volume; CRC cis rs7043114 0.525 rs6479419 chr9:95110002 T/C cg14631576 chr9:95140430 CENPP -0.31 -5.86 -0.31 1.14e-8 Height; CRC cis rs9786986 0.764 rs10925929 chr1:235696885 C/T cg08848088 chr1:235714526 GNG4 0.52 6.2 0.32 1.67e-9 Body mass index; CRC cis rs2380220 1.000 rs9632496 chr6:95976450 C/G cg04719120 chr6:96025338 MANEA 0.57 6.55 0.34 2.24e-10 Behavioural disinhibition (generation interaction); CRC cis rs2204008 0.606 rs6582502 chr12:38543352 C/T cg26384229 chr12:38710491 ALG10B -0.52 -7.56 -0.38 4.18e-13 Bladder cancer; CRC cis rs7209700 0.662 rs8066295 chr17:45348203 A/G cg08085267 chr17:45401833 C17orf57 -0.42 -5.81 -0.31 1.48e-8 IgG glycosylation; CRC cis rs9399135 0.935 rs11754504 chr6:135321509 C/T cg22676075 chr6:135203613 NA 0.41 6.38 0.33 6.03e-10 Red blood cell count; CRC cis rs13118159 0.778 rs12640984 chr4:1338834 G/A cg15763984 chr4:1342303 KIAA1530 0.34 5.64 0.3 3.65e-8 Longevity; CRC cis rs589448 0.867 rs623853 chr12:69753830 G/A cg20891283 chr12:69753455 YEATS4 0.99 21.34 0.76 4.82e-64 Cerebrospinal fluid biomarker levels; CRC cis rs1129187 0.720 rs9471972 chr6:42915021 G/A cg09436375 chr6:42928200 GNMT -0.32 -5.95 -0.31 6.87e-9 Alzheimer's disease in APOE e4+ carriers; CRC cis rs2811415 0.597 rs11721281 chr3:127790935 G/A cg13719885 chr3:127795394 NA -0.39 -5.92 -0.31 8.18e-9 Lung function (FEV1/FVC); CRC cis rs9322193 0.962 rs62439843 chr6:149997657 T/C cg07701084 chr6:150067640 NUP43 0.47 6.63 0.34 1.36e-10 Lung cancer; CRC cis rs7615952 0.576 rs2276729 chr3:125826214 G/A cg18479299 chr3:125709523 NA -0.5 -6.19 -0.32 1.8e-9 Blood pressure (smoking interaction); CRC cis rs7149337 0.780 rs4369569 chr14:51689181 C/G cg23942311 chr14:51606299 NA -0.7 -12.06 -0.55 5.62e-28 Cancer; CRC cis rs1218582 0.804 rs4845398 chr1:154859038 G/C cg24250549 chr1:154909240 PMVK 0.64 10.88 0.51 9.11e-24 Prostate cancer; CRC cis rs1555322 0.530 rs6058224 chr20:33881774 C/T cg13662093 chr20:33865505 NA 0.43 5.8 0.3 1.54e-8 Attention deficit hyperactivity disorder; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg05955566 chr12:99038273 IKBIP;APAF1 0.51 8.02 0.4 1.82e-14 Liver disease severity in Alagille syndrome; CRC cis rs881375 0.935 rs7034390 chr9:123646488 A/T cg09419670 chr9:123605666 PSMD5;LOC253039 0.56 8.2 0.41 5.41e-15 Rheumatoid arthritis; CRC cis rs6429082 0.791 rs61836205 chr1:235638753 C/G cg26050004 chr1:235667680 B3GALNT2 0.59 7.97 0.4 2.71e-14 Adiposity; CRC cis rs7762018 0.891 rs3749882 chr6:170151766 C/T cg17545662 chr6:170176663 C6orf70 0.56 6.38 0.33 5.95e-10 Thiazide-induced adverse metabolic effects in hypertensive patients; CRC cis rs2952156 0.920 rs2952152 chr17:37832735 T/C cg00129232 chr17:37814104 STARD3 -0.68 -11.88 -0.55 2.47e-27 Asthma; CRC trans rs561341 0.941 rs2428341 chr17:30317295 C/T cg27661571 chr11:113659931 NA -0.62 -8.09 -0.41 1.15e-14 Hip circumference adjusted for BMI; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg00306249 chr3:184017680 PSMD2 0.5 7.47 0.38 7.33e-13 Response to antipsychotic treatment; CRC cis rs853679 0.517 rs9357066 chr6:28129831 T/C cg02683197 chr6:28174875 NA 0.87 10.73 0.51 3.25e-23 Depression; CRC cis rs2067615 0.524 rs1922433 chr12:107077172 A/G cg15890332 chr12:107067104 RFX4 0.32 5.67 0.3 3.15e-8 Heart rate; CRC cis rs1799949 0.965 rs9646418 chr17:41425901 A/G cg19454999 chr17:41278357 BRCA1;NBR2 0.39 6.07 0.32 3.49e-9 Menopause (age at onset); CRC cis rs1572438 0.899 rs9379160 chr6:859966 A/G cg13447295 chr6:887704 NA -0.43 -6.51 -0.34 2.86e-10 Aging; CRC cis rs6570726 0.935 rs395948 chr6:145820185 G/A cg23711669 chr6:146136114 FBXO30 0.68 12.16 0.56 2.33e-28 Lobe attachment (rater-scored or self-reported); CRC cis rs514406 0.679 rs541852 chr1:53256834 A/G cg27535305 chr1:53392650 SCP2 0.47 8.53 0.43 5.33e-16 Monocyte count; CRC cis rs7487075 0.859 rs4768698 chr12:46749088 C/T cg22049899 chr12:47219821 SLC38A4 -0.34 -6.77 -0.35 5.8e-11 Itch intensity from mosquito bite; CRC cis rs7666738 0.791 rs4699329 chr4:99056212 G/A cg05340658 chr4:99064831 C4orf37 0.6 9.31 0.46 1.85e-18 Colonoscopy-negative controls vs population controls; CRC cis rs736408 0.509 rs2590838 chr3:52622086 G/A cg10802521 chr3:52805072 NEK4 -0.45 -6.98 -0.36 1.63e-11 Bipolar disorder; CRC cis rs728616 0.681 rs56184245 chr10:82018556 C/T cg05935833 chr10:81318306 SFTPA2 -0.6 -7.18 -0.37 4.63e-12 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs7618915 0.547 rs12496634 chr3:52709259 A/C cg18099408 chr3:52552593 STAB1 -0.44 -7.22 -0.37 3.66e-12 Bipolar disorder; CRC cis rs2976388 0.609 rs2572904 chr8:143792193 A/C cg15511327 chr8:143859410 LYNX1 0.41 7.33 0.37 1.74e-12 Urinary tract infection frequency; CRC cis rs11122272 0.735 rs2247132 chr1:231493359 G/A cg06096015 chr1:231504339 EGLN1 0.39 5.69 0.3 2.8e-8 Hemoglobin concentration; CRC cis rs12701220 0.847 rs10272002 chr7:1047615 A/G cg26240231 chr7:1148101 C7orf50 -0.43 -5.77 -0.3 1.88e-8 Bronchopulmonary dysplasia; CRC cis rs7666738 0.712 rs34043080 chr4:99008748 G/C cg05340658 chr4:99064831 C4orf37 0.58 8.87 0.44 4.85e-17 Colonoscopy-negative controls vs population controls; CRC cis rs769267 1.000 rs7247309 chr19:19439631 A/T cg20644253 chr19:19431407 KIAA0892;SF4 -0.41 -5.73 -0.3 2.33e-8 Tonsillectomy; CRC cis rs2985684 0.894 rs7152110 chr14:50018218 T/C cg04989706 chr14:50066350 PPIL5 -0.59 -8.24 -0.41 4.15e-15 Carotid intima media thickness; CRC cis rs1832871 0.711 rs9457300 chr6:158714609 G/C cg07165851 chr6:158734300 TULP4 0.62 7.76 0.39 1.11e-13 Height; CRC cis rs2239547 0.522 rs6792578 chr3:53004604 G/A cg10802521 chr3:52805072 NEK4 -0.44 -6.21 -0.32 1.63e-9 Schizophrenia; CRC cis rs780096 0.506 rs2303369 chr2:27715416 C/T cg12648201 chr2:27665141 KRTCAP3 -0.32 -6.09 -0.32 3.23e-9 Total body bone mineral density; CRC cis rs12530845 0.887 rs6948382 chr7:135323576 G/A cg23117316 chr7:135346802 PL-5283 -0.41 -5.67 -0.3 3.06e-8 Red blood cell traits; CRC cis rs796364 0.951 rs281769 chr2:200809709 T/C cg23649088 chr2:200775458 C2orf69 0.55 5.95 0.31 6.71e-9 Schizophrenia; CRC cis rs853679 0.517 rs9468286 chr6:28079428 C/T cg02683197 chr6:28174875 NA 0.85 10.27 0.49 1.16e-21 Depression; CRC cis rs9926296 0.533 rs9938865 chr16:89867797 A/G cg27121462 chr16:89883253 FANCA 0.6 9.77 0.47 5.65e-20 Vitiligo; CRC trans rs10021731 0.718 rs13104081 chr4:115453797 A/G cg25927708 chr2:119603813 EN1 -0.34 -6.41 -0.33 5.11e-10 Optic disc area; CRC cis rs7680126 0.644 rs4697703 chr4:10107431 A/G cg00071950 chr4:10020882 SLC2A9 -0.52 -6.95 -0.36 1.92e-11 Urate levels in lean individuals;Urate levels in overweight individuals;Urate levels in obese individuals; CRC cis rs250677 0.687 rs36044 chr5:148441128 T/C cg23229984 chr5:148520753 ABLIM3 0.49 6.83 0.35 4.05e-11 Breast cancer; CRC cis rs2120019 0.567 rs8025170 chr15:75170983 A/G cg09165964 chr15:75287851 SCAMP5 0.62 7.61 0.39 2.93e-13 Blood trace element (Zn levels); CRC cis rs910187 0.605 rs2235907 chr20:45809652 A/G cg27589058 chr20:45804311 EYA2 -0.4 -7.73 -0.39 1.33e-13 Migraine; CRC cis rs4660306 0.677 rs781061 chr1:45932887 T/C cg03123370 chr1:45965343 CCDC163P;MMACHC 0.49 6.5 0.34 3.01e-10 Homocysteine levels; CRC cis rs7666738 0.830 rs10012003 chr4:99064881 A/G cg05340658 chr4:99064831 C4orf37 0.6 9.38 0.46 1.1e-18 Colonoscopy-negative controls vs population controls; CRC cis rs12701220 0.655 rs7778968 chr7:1144622 C/G cg00990874 chr7:1149470 C7orf50 -0.71 -9.19 -0.45 4.46e-18 Bronchopulmonary dysplasia; CRC cis rs7493 1.000 rs3735586 chr7:95035582 A/T cg01874867 chr7:94954059 PON1 -0.49 -6.32 -0.33 8.45e-10 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs17826219 0.568 rs9898097 chr17:29072672 T/G cg13385521 chr17:29058706 SUZ12P 0.72 8.17 0.41 6.77e-15 Body mass index; CRC cis rs72799341 0.706 rs1060506 chr16:31133449 C/T cg02466173 chr16:30829666 NA -0.44 -5.98 -0.31 5.89e-9 Diastolic blood pressure; CRC cis rs2777491 0.915 rs16971767 chr15:41623308 T/C cg18705301 chr15:41695430 NDUFAF1 -0.69 -11.44 -0.53 9.57e-26 Ulcerative colitis; CRC cis rs11122272 0.735 rs2437149 chr1:231490105 C/T cg06096015 chr1:231504339 EGLN1 0.42 6.39 0.33 5.73e-10 Hemoglobin concentration; CRC cis rs4727027 0.933 rs13225884 chr7:148857795 A/G cg23583168 chr7:148888333 NA -0.92 -16.26 -0.67 4.88e-44 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC cis rs10832963 0.961 rs10832954 chr11:18643559 G/A cg09201001 chr11:18656081 SPTY2D1 0.8 12.57 0.57 7.26e-30 Breast cancer; CRC cis rs3785574 0.962 rs56295011 chr17:61850359 A/G cg06601766 chr17:61851465 DDX42;CCDC47 0.6 8.54 0.43 5.06e-16 Height; CRC cis rs4727027 0.933 rs12704062 chr7:148827865 G/A cg12479418 chr7:148823350 ZNF425;ZNF398 0.44 5.88 0.31 1e-8 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC cis rs11122272 0.525 rs2739517 chr1:231537914 C/A cg06096015 chr1:231504339 EGLN1 0.42 6.2 0.32 1.69e-9 Hemoglobin concentration; CRC cis rs868943 0.743 rs13192924 chr6:116352332 T/C cg05304507 chr6:116381966 FRK 0.29 6.52 0.34 2.61e-10 Total cholesterol levels; CRC cis rs6546550 0.935 rs2872075 chr2:70068635 G/T cg02498382 chr2:70120550 SNRNP27 -0.49 -7.89 -0.4 4.53e-14 Prevalent atrial fibrillation; CRC cis rs9488822 0.597 rs12214881 chr6:116342187 G/T cg26893134 chr6:116381904 FRK 0.27 7.77 0.39 9.88e-14 Cholesterol, total;LDL cholesterol; CRC trans rs7395662 0.591 rs4882110 chr11:48558249 G/T cg21153622 chr11:89784906 NA -0.51 -8.48 -0.42 7.88e-16 HDL cholesterol; CRC cis rs921968 0.541 rs3845835 chr2:219342284 T/C cg02176678 chr2:219576539 TTLL4 -0.57 -9.18 -0.45 4.97e-18 Mean corpuscular hemoglobin concentration; CRC cis rs597539 0.652 rs686390 chr11:68656077 T/C cg06112835 chr11:68658793 MRPL21 0.48 7.5 0.38 6.18e-13 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs35306767 0.953 rs12259338 chr10:969377 C/T cg26597838 chr10:835615 NA 0.8 10.22 0.49 1.81e-21 Eosinophil percentage of granulocytes; CRC cis rs4149423 1.000 rs4149420 chr2:108913090 G/T cg25838818 chr2:108905173 SULT1C2 -0.49 -7.87 -0.4 5.07e-14 Lobe size; CRC cis rs7945705 0.875 rs2568065 chr11:8889648 C/T cg21881798 chr11:8931708 C11orf17;ST5 -0.74 -12.56 -0.57 8e-30 Hemoglobin concentration; CRC cis rs7635838 0.718 rs2606736 chr3:11400249 C/T cg00170343 chr3:11313890 ATG7 0.48 7.33 0.37 1.79e-12 HDL cholesterol; CRC cis rs9381040 0.610 rs2294694 chr6:41046177 G/A cg04346459 chr6:41068666 NFYA;LOC221442 -0.4 -5.82 -0.31 1.43e-8 Alzheimer's disease (late onset); CRC cis rs34375054 0.687 rs35540170 chr12:125669122 C/G cg20959480 chr12:125599568 AACS 0.39 5.62 0.3 4.04e-8 Post bronchodilator FEV1/FVC ratio; CRC cis rs6088590 0.965 rs13040449 chr20:33358901 T/A cg24642439 chr20:33292090 TP53INP2 0.62 10.85 0.51 1.16e-23 Coronary artery disease; CRC cis rs116095464 0.558 rs3213838 chr5:223890 G/C cg22857025 chr5:266934 NA -1.22 -16.66 -0.68 1.26e-45 Breast cancer; CRC cis rs3008870 1.000 rs3008853 chr1:67385488 C/T cg08660285 chr1:67390436 MIER1;WDR78 1.04 16.07 0.66 2.57e-43 Lymphocyte percentage of white cells; CRC cis rs4731207 0.698 rs7796150 chr7:124521217 C/T cg23710748 chr7:124431027 NA -0.37 -6.09 -0.32 3.2e-9 Cutaneous malignant melanoma; CRC cis rs4727027 0.737 rs10278971 chr7:148780659 A/T cg12479418 chr7:148823350 ZNF425;ZNF398 0.42 5.73 0.3 2.23e-8 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC cis rs365302 0.909 rs12191109 chr6:159652103 C/A cg14500486 chr6:159655392 FNDC1 -0.44 -6.82 -0.35 4.31e-11 Coronary heart disease; CRC trans rs3780486 0.846 rs6476402 chr9:33148552 G/A cg04842962 chr6:43655489 MRPS18A 1.15 24.64 0.81 1.07e-76 IgG glycosylation; CRC cis rs9916302 0.904 rs57399933 chr17:37551189 A/G cg03013999 chr17:37608204 MED1 -0.47 -7.31 -0.37 2e-12 Glomerular filtration rate (creatinine); CRC cis rs734999 0.588 rs3748818 chr1:2525660 G/A cg20673091 chr1:2541236 MMEL1 0.36 5.82 0.31 1.39e-8 Ulcerative colitis; CRC cis rs939574 0.858 rs2891733 chr2:220135208 A/G cg00496455 chr2:220118770 TUBA4A;TUBA4B 0.7 7.57 0.39 3.71e-13 Platelet distribution width; CRC cis rs1218582 0.774 rs4845680 chr1:154863195 A/G cg09359103 chr1:154839909 KCNN3 -0.74 -13.15 -0.59 5.08e-32 Prostate cancer; CRC cis rs3617 0.625 rs11922961 chr3:52868610 T/C cg11645453 chr3:52864694 ITIH4 -0.46 -9.3 -0.46 2.08e-18 Red blood cell count;Autism spectrum disorder or schizophrenia; CRC cis rs7605827 0.866 rs2276664 chr2:15701002 A/T cg19274914 chr2:15703543 NA 0.37 5.63 0.3 3.95e-8 Educational attainment (years of education); CRC cis rs10992471 0.528 rs1924244 chr9:95224952 A/G cg14631576 chr9:95140430 CENPP -0.34 -6.27 -0.33 1.11e-9 Visceral adipose tissue/subcutaneous adipose tissue ratio; CRC cis rs10876993 0.672 rs2640611 chr12:58037757 T/A cg18357645 chr12:58087776 OS9 0.52 6.99 0.36 1.56e-11 Celiac disease or Rheumatoid arthritis; CRC cis rs10479542 0.752 rs12658664 chr5:178986987 C/T cg19626725 chr5:178986131 RUFY1 0.37 7.41 0.38 1.07e-12 Lung cancer; CRC cis rs561341 0.883 rs7406056 chr17:30220224 C/T cg23018236 chr17:30244563 NA -0.57 -7.15 -0.37 5.62e-12 Hip circumference adjusted for BMI; CRC cis rs7615952 0.932 rs13314869 chr3:125644669 G/A cg05084668 chr3:125655381 ALG1L -0.62 -9.36 -0.46 1.29e-18 Blood pressure (smoking interaction); CRC cis rs1448094 0.791 rs61929395 chr12:86331584 A/T cg00310523 chr12:86230176 RASSF9 0.43 7.28 0.37 2.42e-12 Major depressive disorder; CRC cis rs2980439 0.818 rs2948294 chr8:8094961 A/G cg08975724 chr8:8085496 FLJ10661 0.51 7.61 0.39 2.87e-13 Neuroticism; CRC cis rs6952808 0.717 rs10950422 chr7:1926577 T/C cg00106254 chr7:1943704 MAD1L1 -0.37 -5.88 -0.31 1.03e-8 Bipolar disorder and schizophrenia; CRC cis rs11931598 0.514 rs10937779 chr4:7039326 G/A cg19539972 chr4:7069911 GRPEL1 0.41 6.01 0.31 4.87e-9 Sum basophil neutrophil counts;Sum neutrophil eosinophil counts;Granulocyte count;Neutrophil count;Myeloid white cell count; CRC cis rs2832191 1.000 rs2832189 chr21:30487414 C/T cg24692254 chr21:30365293 RNF160 -0.65 -11.2 -0.53 6.89e-25 Dental caries; CRC cis rs17376456 0.877 rs10213956 chr5:93460839 C/T cg25358565 chr5:93447407 FAM172A 1.02 10.5 0.5 1.92e-22 Diabetic retinopathy; CRC cis rs9811920 0.609 rs793463 chr3:99620252 T/C cg07805332 chr3:99536008 MIR548G;C3orf26 -0.51 -7.64 -0.39 2.35e-13 Axial length; CRC cis rs1577917 0.958 rs12192546 chr6:86476484 A/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A 0.6 7.55 0.38 4.39e-13 Response to antipsychotic treatment; CRC cis rs904251 0.737 rs914347 chr6:37484970 A/C cg25019722 chr6:37503610 NA -0.48 -8.87 -0.44 4.78e-17 Cognitive performance; CRC cis rs1153858 0.887 rs7164139 chr15:45670851 G/A cg21132104 chr15:45694354 SPATA5L1 0.57 8.29 0.42 2.85e-15 Homoarginine levels; CRC cis rs1552244 0.935 rs35515831 chr3:10071362 G/A cg00166722 chr3:10149974 C3orf24 0.66 8.88 0.44 4.36e-17 Alzheimer's disease; CRC trans rs7976838 0.808 rs12824305 chr12:60145729 C/T cg16974014 chr22:22007515 MIR130B 0.49 6.0 0.31 5.21e-9 Response to zileuton treatment in asthma (FEV1 change interaction); CRC cis rs12477438 0.520 rs6542864 chr2:99725223 A/G cg14399236 chr2:99771627 LIPT1;TSGA10 0.82 14.35 0.62 1.31e-36 Chronic sinus infection; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg25079743 chr16:30441674 DCTPP1 0.44 6.25 0.33 1.25e-9 Response to antipsychotic treatment; CRC trans rs7395662 1.000 rs11039851 chr11:48600839 A/G cg21153622 chr11:89784906 NA -0.45 -7.27 -0.37 2.58e-12 HDL cholesterol; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg15057251 chr18:32621312 MAPRE2 0.47 6.99 0.36 1.54e-11 Response to antipsychotic treatment; CRC cis rs4891159 0.526 rs2848961 chr18:74129886 C/G cg24786174 chr18:74118243 ZNF516 -0.88 -19.72 -0.74 1.11e-57 Longevity; CRC trans rs7819412 0.775 rs4841490 chr8:10936891 T/C cg16141378 chr3:129829833 LOC729375 0.45 6.44 0.33 4.33e-10 Triglycerides; CRC cis rs2032447 0.702 rs199753 chr6:26001888 G/A cg12310025 chr6:25882481 NA -0.58 -8.06 -0.41 1.42e-14 Intelligence (multi-trait analysis); CRC cis rs12422267 0.536 rs12303540 chr12:132609679 A/G cg09764611 chr12:132620959 NA 0.6 8.37 0.42 1.7e-15 Plasma amyloid beta peptide concentrations (ABx-40); CRC cis rs6912958 0.781 rs9444512 chr6:88223397 G/A cg08069147 chr6:88032118 GJB7;C6orf162 -0.57 -8.45 -0.42 9.25e-16 Monocyte percentage of white cells; CRC cis rs457287 1.000 rs692725 chr9:4835173 G/A cg14182974 chr9:4791918 RCL1 0.43 6.29 0.33 1.01e-9 Platelet count; CRC trans rs1455244 0.700 rs7229302 chr18:11508904 G/T cg06077046 chr15:49913394 C15orf33;DTWD1 0.41 6.08 0.32 3.24e-9 Schizophrenia; CRC cis rs4689592 0.523 rs3857179 chr4:7070496 T/A cg06697600 chr4:7070879 GRPEL1 -0.49 -7.2 -0.37 4.05e-12 Monocyte percentage of white cells; CRC cis rs769267 0.896 rs7250893 chr19:19625547 A/G cg02546618 chr19:19431379 KIAA0892;SF4 0.44 6.08 0.32 3.33e-9 Tonsillectomy; CRC cis rs9783347 1.000 rs4150564 chr11:18355308 G/A cg15585147 chr11:18324498 HPS5 0.45 6.34 0.33 7.44e-10 Pancreatic cancer; CRC trans rs7615952 0.512 rs2979336 chr3:125357470 G/A cg08546805 chr12:8549446 NA -0.43 -6.47 -0.34 3.45e-10 Blood pressure (smoking interaction); CRC cis rs2857891 1.000 rs2857891 chr11:6962957 C/T cg26870460 chr11:6947759 ZNF215 0.56 5.85 0.31 1.18e-8 Response to cytadine analogues (cytosine arabinoside); CRC cis rs801193 0.569 rs35070132 chr7:66238083 C/T cg12463550 chr7:65579703 CRCP 0.44 5.89 0.31 9.58e-9 Aortic root size; CRC cis rs9322817 0.691 rs7753202 chr6:105215289 T/C cg02098413 chr6:105308735 HACE1 -0.44 -8.51 -0.42 6.37e-16 Thyroid stimulating hormone; CRC cis rs2576037 0.523 rs4890705 chr18:44509758 A/G cg19077165 chr18:44547161 KATNAL2 -0.7 -11.82 -0.55 4.01e-27 Personality dimensions; CRC cis rs7737355 0.947 rs6859469 chr5:130962546 C/T cg06307176 chr5:131281290 NA 0.45 6.45 0.34 3.91e-10 Life satisfaction; CRC cis rs7703744 0.634 rs3797340 chr5:118691737 C/G cg19893178 chr5:118692011 TNFAIP8 0.44 5.85 0.31 1.18e-8 Lobe attachment (rater-scored or self-reported); CRC cis rs6502050 0.734 rs7217625 chr17:80157766 T/C cg13198984 chr17:80129470 CCDC57 0.45 8.01 0.4 1.99e-14 Life satisfaction; CRC cis rs9309711 0.544 rs9309712 chr2:3491327 G/T cg08493051 chr2:3487164 NA -0.41 -6.03 -0.32 4.42e-9 Neurofibrillary tangles; CRC trans rs7726839 0.540 rs3749618 chr5:602650 A/G cg25482853 chr8:67687455 SGK3 1.11 12.97 0.58 2.27e-31 Obesity-related traits; CRC cis rs13256369 1.000 rs12547721 chr8:8570671 C/T cg17143192 chr8:8559678 CLDN23 0.48 6.25 0.33 1.28e-9 Obesity-related traits; CRC cis rs12134245 0.747 rs11164929 chr1:92012836 G/C cg21854759 chr1:92012499 NA -0.62 -10.65 -0.51 5.83e-23 Breast cancer; CRC cis rs2798269 0.528 rs9509810 chr13:22169006 C/T cg18095732 chr13:22033692 ZDHHC20 0.41 6.44 0.33 4.32e-10 PR segment; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg20386705 chr6:38607295 BTBD9 0.46 6.0 0.31 5.26e-9 Thyroid stimulating hormone; CRC cis rs9649213 0.593 rs6465665 chr7:97934150 T/C cg21770322 chr7:97807741 LMTK2 0.5 8.14 0.41 8.24e-15 Prostate cancer (SNP x SNP interaction); CRC cis rs713477 0.967 rs6573032 chr14:55913776 A/G cg13175173 chr14:55914753 NA -0.52 -9.9 -0.48 2.06e-20 Pediatric bone mineral content (femoral neck); CRC cis rs2404602 0.583 rs12592501 chr15:76554790 C/A cg23625390 chr15:77176239 SCAPER 0.39 5.79 0.3 1.61e-8 Blood metabolite levels; CRC cis rs73195822 0.667 rs7967278 chr12:111239011 C/T cg12870014 chr12:110450643 ANKRD13A 0.65 5.68 0.3 2.9e-8 Itch intensity from mosquito bite; CRC cis rs35306767 0.855 rs61830900 chr10:871481 C/G cg26597838 chr10:835615 NA 1.25 15.12 0.64 1.35e-39 Eosinophil percentage of granulocytes; CRC cis rs2243480 0.901 rs34807232 chr7:65965133 G/A cg18252515 chr7:66147081 NA -1.29 -15.4 -0.65 1.09e-40 Diabetic kidney disease; CRC cis rs58804349 0.685 rs9422671 chr10:43288626 T/G cg15903213 chr10:43522190 NA -0.74 -5.75 -0.3 2.01e-8 Pediatric bone mineral content (radius); CRC cis rs10256972 0.616 rs6463001 chr7:1108272 A/C cg04025307 chr7:1156635 C7orf50 0.4 6.14 0.32 2.37e-9 Longevity;Endometriosis; CRC cis rs9368481 0.700 rs6911401 chr6:26913214 C/G cg05192639 chr6:26864778 GUSBL1 0.33 6.0 0.31 5.26e-9 Autism spectrum disorder or schizophrenia; CRC cis rs7772486 0.597 rs6570732 chr6:146245151 G/A cg23711669 chr6:146136114 FBXO30 -0.65 -9.75 -0.47 6.81e-20 Lobe attachment (rater-scored or self-reported); CRC cis rs4665809 0.938 rs6742226 chr2:26342537 A/G cg27170947 chr2:26402098 FAM59B -0.45 -6.04 -0.32 4.1e-9 Gut microbiome composition (summer); CRC cis rs501916 0.796 rs628501 chr15:48027328 C/G cg16110827 chr15:48056943 SEMA6D -0.5 -7.7 -0.39 1.61e-13 Inflammatory bowel disease;Ulcerative colitis; CRC cis rs561341 1.000 rs111454793 chr17:30319267 T/C cg19193384 chr17:30244184 NA -0.65 -7.57 -0.39 3.82e-13 Hip circumference adjusted for BMI; CRC cis rs7149337 0.805 rs2999355 chr14:51607084 A/G cg23942311 chr14:51606299 NA 0.83 17.41 0.69 1.4e-48 Cancer; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg21403089 chr7:108166784 PNPLA8 0.41 6.96 0.36 1.84e-11 Liver disease severity in Alagille syndrome; CRC cis rs1577917 0.771 rs9362237 chr6:86409064 G/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A 0.69 9.26 0.45 2.75e-18 Response to antipsychotic treatment; CRC cis rs1577917 0.958 rs12213431 chr6:86500956 A/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.53 -7.26 -0.37 2.89e-12 Response to antipsychotic treatment; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg19310740 chr8:103424477 UBR5 0.49 6.38 0.33 6.14e-10 Thyroid stimulating hormone; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg10261958 chr15:38544292 SPRED1 0.43 6.14 0.32 2.43e-9 Intelligence (multi-trait analysis); CRC cis rs4481887 0.927 rs4244181 chr1:248471118 A/G cg00666640 chr1:248458726 OR2T12 0.54 9.63 0.47 1.74e-19 Common traits (Other); CRC cis rs11190604 1.000 rs11190569 chr10:102227409 C/T cg16342193 chr10:102329863 NA -0.34 -5.61 -0.3 4.35e-8 Palmitoleic acid (16:1n-7) levels; CRC cis rs2013441 1.000 rs2526458 chr17:20092200 C/T cg13482628 chr17:19912719 NA -0.4 -6.07 -0.32 3.43e-9 Obesity-related traits; CRC cis rs7107174 0.748 rs2063730 chr11:78048524 A/C cg02023728 chr11:77925099 USP35 0.46 7.16 0.37 5.43e-12 Testicular germ cell tumor; CRC cis rs763121 0.853 rs5750659 chr22:39068789 T/C cg06544989 chr22:39130855 UNC84B 0.45 6.9 0.36 2.7e-11 Menopause (age at onset); CRC cis rs9443645 0.901 rs9361480 chr6:79724429 C/T cg05283184 chr6:79620031 NA -0.56 -8.71 -0.43 1.46e-16 Intelligence (multi-trait analysis); CRC cis rs9323205 0.723 rs12587352 chr14:51739441 T/C cg23942311 chr14:51606299 NA -0.5 -5.75 -0.3 2.09e-8 Cancer; CRC cis rs8177179 1.000 rs8177179 chr3:133463457 G/A cg17775713 chr3:133465469 TF 0.37 6.81 0.35 4.55e-11 Iron status biomarkers (transferrin levels); CRC cis rs4253772 0.591 rs6007748 chr22:46657798 A/G cg03482458 chr22:46692211 CN5H6.4;GTSE1 0.51 6.93 0.36 2.17e-11 LDL cholesterol;Cholesterol, total; CRC cis rs1552244 0.882 rs112621205 chr3:10017916 G/A cg02579736 chr3:10068473 FANCD2;CIDECP 0.93 11.94 0.55 1.55e-27 Alzheimer's disease; CRC cis rs1707322 0.721 rs4564187 chr1:46166861 G/C cg06784218 chr1:46089804 CCDC17 0.66 12.38 0.56 3.81e-29 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC trans rs2243480 1.000 rs313802 chr7:65516373 A/G cg10756647 chr7:56101905 PSPH 0.75 7.66 0.39 2.05e-13 Diabetic kidney disease; CRC cis rs8031584 0.958 rs7168641 chr15:31235452 G/A cg14829155 chr15:31115871 NA -0.49 -7.88 -0.4 4.77e-14 Huntington's disease progression; CRC cis rs10760158 0.800 rs4837823 chr9:124012011 T/A cg14417974 chr9:124058376 GSN -0.34 -5.7 -0.3 2.62e-8 Pulse pressure; CRC trans rs3780486 0.846 rs4584234 chr9:33147479 G/A cg04842962 chr6:43655489 MRPS18A 1.15 24.77 0.81 3.54e-77 IgG glycosylation; CRC cis rs2346160 0.899 rs1736585 chr6:167688325 G/A cg04673565 chr6:167680447 NA -0.39 -6.58 -0.34 1.8e-10 Parental extreme longevity (95 years and older); CRC trans rs8073060 0.927 rs7502331 chr17:33868858 A/G cg19694781 chr19:47549865 TMEM160 0.5 7.28 0.37 2.52e-12 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; CRC cis rs28386778 0.897 rs1062788 chr17:61896127 C/G cg07362569 chr17:61921086 SMARCD2 0.38 5.95 0.31 6.87e-9 Prudent dietary pattern; CRC cis rs875971 0.545 rs13311962 chr7:66068129 C/T cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.58 -7.35 -0.38 1.59e-12 Aortic root size; CRC cis rs7412746 0.658 rs3768015 chr1:150812954 C/T cg15448220 chr1:150897856 SETDB1 0.55 7.76 0.39 1.07e-13 Melanoma; CRC cis rs6977660 0.562 rs2189566 chr7:19768960 G/A cg07541023 chr7:19748670 TWISTNB 0.79 7.44 0.38 8.86e-13 Thyroid stimulating hormone; CRC cis rs3812049 0.737 rs1112956 chr5:127433798 C/T cg25462716 chr5:127418816 SLC12A2;FLJ33630 -0.66 -7.76 -0.39 1.11e-13 Lymphocyte counts;Red cell distribution width; CRC cis rs282587 0.569 rs426765 chr13:113414798 A/T cg04656015 chr13:113407548 ATP11A 0.59 7.56 0.38 3.96e-13 Glycated hemoglobin levels; CRC cis rs853679 0.517 rs9366715 chr6:28064633 A/G cg18032046 chr6:28092343 ZSCAN16 -0.5 -5.89 -0.31 9.34e-9 Depression; CRC cis rs10256972 0.591 rs6950319 chr7:1161324 A/G cg22907277 chr7:1156413 C7orf50 0.75 11.82 0.55 4.32e-27 Longevity;Endometriosis; CRC cis rs7737355 0.812 rs10054168 chr5:130788698 C/T cg25547332 chr5:131281432 NA -0.38 -6.13 -0.32 2.57e-9 Life satisfaction; CRC cis rs10504229 1.000 rs77120900 chr8:58170368 C/T cg02725872 chr8:58115012 NA -0.38 -6.43 -0.33 4.44e-10 Developmental language disorder (linguistic errors); CRC trans rs2321882 0.834 rs746717 chr13:59476752 A/G cg04268950 chr11:130298854 ADAMTS8 -0.45 -5.99 -0.31 5.64e-9 Body mass index; CRC cis rs7044106 0.537 rs4434680 chr9:123489688 A/G cg09419670 chr9:123605666 PSMD5;LOC253039 0.76 10.46 0.5 2.74e-22 Hip circumference adjusted for BMI; CRC cis rs7312933 1.000 rs11181308 chr12:42445259 A/G cg17420585 chr12:42539391 GXYLT1 -0.44 -6.32 -0.33 8.41e-10 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CRC trans rs1597595 0.857 rs6719702 chr2:147907637 C/T cg11888359 chr19:4936127 UHRF1 0.45 6.05 0.32 3.92e-9 HDL cholesterol change in response to fenofibrate in statin-treated type 2 diabetes; CRC cis rs11148252 0.967 rs11618716 chr13:53046836 A/G cg02158880 chr13:53174818 NA -0.47 -7.37 -0.38 1.36e-12 Lewy body disease; CRC cis rs7043114 0.507 rs10761154 chr9:95144086 A/G cg14631576 chr9:95140430 CENPP -0.31 -5.9 -0.31 8.88e-9 Height; CRC trans rs2228479 0.850 rs12597299 chr16:89822364 C/A cg24644049 chr4:85504048 CDS1 0.86 6.93 0.36 2.29e-11 Skin colour saturation; CRC cis rs3791556 0.898 rs3828222 chr2:240109568 A/G cg03281426 chr2:240109471 HDAC4 -0.7 -9.12 -0.45 7.38e-18 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs4680 1.000 rs165656 chr22:19948863 C/G cg01335087 chr22:19950166 COMT -0.23 -6.58 -0.34 1.84e-10 Blood metabolite levels; CRC cis rs9309473 0.950 rs6740766 chr2:73780913 A/G cg20560298 chr2:73613845 ALMS1 -0.48 -5.96 -0.31 6.5e-9 Metabolite levels; CRC trans rs1814175 0.654 rs1164676 chr11:49324868 T/C cg11707556 chr5:10655725 ANKRD33B 0.37 6.49 0.34 3.21e-10 Height; CRC cis rs911119 0.913 rs6048924 chr20:23578996 G/A cg16589663 chr20:23618590 CST3 0.42 5.85 0.31 1.2e-8 Chronic kidney disease; CRC cis rs2070677 0.799 rs11101854 chr10:135394430 G/A cg16964102 chr10:135390573 NA 0.53 7.44 0.38 8.92e-13 Gout; CRC cis rs1023500 0.505 rs134887 chr22:42674239 A/G cg04733989 chr22:42467013 NAGA 0.41 5.89 0.31 9.48e-9 Schizophrenia; CRC cis rs1129187 0.755 rs3293 chr6:42938377 G/T cg02353165 chr6:42928485 GNMT 0.71 12.08 0.55 4.59e-28 Alzheimer's disease in APOE e4+ carriers; CRC trans rs11098499 0.820 rs28578366 chr4:120536905 A/G cg25214090 chr10:38739885 LOC399744 -0.65 -10.06 -0.49 6.32e-21 Corneal astigmatism; CRC cis rs28655083 0.957 rs2171096 chr16:77079043 T/C cg01753188 chr16:77233325 SYCE1L;MON1B -0.54 -7.51 -0.38 5.5e-13 Lobe attachment (rater-scored or self-reported); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg26320760 chr14:89021243 PTPN21 0.41 6.55 0.34 2.2e-10 Liver disease severity in Alagille syndrome; CRC cis rs4713118 0.824 rs9468229 chr6:27750086 G/A cg08798685 chr6:27730294 NA -0.48 -6.66 -0.34 1.12e-10 Parkinson's disease; CRC trans rs561341 0.739 rs6505267 chr17:30225950 A/C cg20587970 chr11:113659929 NA -0.65 -8.42 -0.42 1.15e-15 Hip circumference adjusted for BMI; CRC cis rs12586317 0.547 rs76770287 chr14:35487210 C/A cg16230307 chr14:35515116 FAM177A1 0.87 10.25 0.49 1.43e-21 Psoriasis; CRC cis rs1256061 0.624 rs1152577 chr14:64697485 T/G cg23250157 chr14:64679961 SYNE2 0.46 7.12 0.37 6.85e-12 Hemoglobin concentration;Red blood cell count;Hematocrit; CRC cis rs9486715 0.867 rs1127175 chr6:96999725 C/T cg06623918 chr6:96969491 KIAA0776 -0.99 -18.93 -0.72 1.46e-54 Headache; CRC cis rs17234274 0.600 rs10767019 chr11:23234911 C/T cg05245346 chr11:23248277 NA 0.35 5.66 0.3 3.21e-8 Cancer; CRC trans rs853679 1.000 rs1936365 chr6:28268452 C/G cg06606381 chr12:133084897 FBRSL1 0.61 6.46 0.34 3.72e-10 Depression; CRC cis rs7215564 0.908 rs34785514 chr17:78661166 A/G cg09596252 chr17:78655493 RPTOR 0.54 5.73 0.3 2.25e-8 Myopia (pathological); CRC cis rs17767294 0.612 rs9461424 chr6:27919401 G/A cg03623178 chr6:28175578 NA 0.72 7.21 0.37 3.76e-12 Parkinson's disease; CRC cis rs1568889 1.000 rs7934085 chr11:28369660 G/C cg06544937 chr11:28130018 METT5D1;KIF18A 0.79 11.36 0.53 1.83e-25 Bipolar disorder; CRC cis rs4332037 0.713 rs56093134 chr7:1973970 C/T cg23378565 chr7:2036160 MAD1L1 -0.44 -6.1 -0.32 3.05e-9 Bipolar disorder; CRC cis rs870825 0.860 rs72689284 chr4:185596680 A/G cg04058563 chr4:185651563 MLF1IP 0.63 6.53 0.34 2.51e-10 Blood protein levels; CRC cis rs9372498 0.536 rs1319988 chr6:118782379 G/A cg10217327 chr6:118973057 C6orf204 0.51 5.76 0.3 1.93e-8 Diastolic blood pressure; CRC cis rs992157 0.835 rs10932769 chr2:219147245 T/G cg13835894 chr2:219148914 PNKD;TMBIM1 -0.36 -6.85 -0.35 3.56e-11 Colorectal cancer; CRC cis rs929354 0.566 rs6979947 chr7:157005863 C/T cg17757837 chr7:157058334 UBE3C -0.63 -9.73 -0.47 7.67e-20 Body mass index; CRC cis rs7618915 0.501 rs7624716 chr3:52751534 T/C cg11645453 chr3:52864694 ITIH4 0.37 6.53 0.34 2.57e-10 Bipolar disorder; CRC trans rs2303319 0.504 rs1006428 chr2:162592559 A/C cg12500891 chr11:57225987 NA -0.65 -6.06 -0.32 3.77e-9 Cognitive function; CRC cis rs17767392 1.000 rs7142180 chr14:71759895 T/G cg13720639 chr14:72061746 SIPA1L1 -0.53 -6.82 -0.35 4.34e-11 Mitral valve prolapse; CRC cis rs6783573 0.711 rs3806701 chr3:46617337 G/A cg27371741 chr3:46619158 LRRC2;TDGF1 -0.44 -5.95 -0.31 6.79e-9 Cerebrospinal fluid biomarker levels; CRC cis rs2290405 0.527 rs6829987 chr4:932974 C/G cg10113582 chr4:905918 GAK 0.39 5.6 0.3 4.42e-8 Systemic sclerosis; CRC cis rs155076 0.711 rs9550724 chr13:21885030 G/T cg21970626 chr13:21893289 NA -0.45 -6.77 -0.35 5.93e-11 White matter hyperintensity burden; CRC cis rs812925 0.659 rs2167565 chr2:61476458 C/T cg10580144 chr2:61372316 C2orf74 -0.33 -6.78 -0.35 5.57e-11 Immature fraction of reticulocytes; CRC cis rs35306767 0.903 rs7067865 chr10:908387 C/T cg26597838 chr10:835615 NA 0.98 11.97 0.55 1.17e-27 Eosinophil percentage of granulocytes; CRC cis rs898097 1.000 rs898098 chr17:80904564 G/A cg15664640 chr17:80829946 TBCD 0.58 9.68 0.47 1.19e-19 Breast cancer; CRC cis rs881375 0.678 rs10760125 chr9:123662590 G/A cg14255062 chr9:123606675 PSMD5;LOC253039 0.39 6.08 0.32 3.26e-9 Rheumatoid arthritis; CRC cis rs2019137 0.560 rs6707386 chr2:113981022 G/A cg17445212 chr2:113993313 PAX8;LOC440839;LOC654433 0.49 7.32 0.37 1.94e-12 Lymphocyte counts; CRC cis rs12477438 0.605 rs4585080 chr2:99557327 T/C cg26064155 chr2:99771622 LIPT1;TSGA10 -0.61 -8.45 -0.42 9.33e-16 Chronic sinus infection; CRC cis rs11764590 0.715 rs55810445 chr7:2103739 C/T cg02825527 chr7:2087843 MAD1L1 -0.52 -6.28 -0.33 1.08e-9 Neuroticism; CRC cis rs3764563 1.000 rs4239617 chr19:15741537 C/T cg20725493 chr19:15740067 CYP4F8 -0.73 -7.61 -0.39 2.83e-13 Inflammatory biomarkers; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg01166180 chr19:36606541 POLR2I;TBCB 0.51 6.48 0.34 3.26e-10 Thyroid stimulating hormone; CRC trans rs925098 0.577 rs2724470 chr4:17996046 A/G cg10684905 chr12:2999782 TULP3 -0.4 -6.0 -0.31 5.18e-9 Birth weight;Height; CRC cis rs4819052 0.851 rs8126930 chr21:46671715 A/G cg19498844 chr21:46707878 POFUT2;LOC642852 0.68 9.93 0.48 1.71e-20 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs7224737 1.000 rs8070446 chr17:40285879 G/A cg02450064 chr17:40260053 DHX58 -0.43 -6.24 -0.33 1.38e-9 Fibrinogen levels; CRC cis rs4908768 0.539 rs7547411 chr1:8638145 A/G cg20416874 chr1:8611966 RERE -0.42 -5.91 -0.31 8.69e-9 Neuroticism (multi-trait analysis);Subjective well-being (multi-trait analysis); CRC cis rs28386778 0.897 rs2727323 chr17:61921999 G/T cg22520471 chr17:61851767 DDX42;CCDC47 0.74 11.65 0.54 1.76e-26 Prudent dietary pattern; CRC cis rs1129187 0.755 rs4714638 chr6:42917017 A/G cg03790207 chr6:42947109 PEX6 -0.49 -6.91 -0.36 2.47e-11 Alzheimer's disease in APOE e4+ carriers; CRC trans rs3749237 0.964 rs1799843 chr3:49849723 G/A cg21665057 chr3:196295764 WDR53;FBXO45 0.55 7.92 0.4 3.66e-14 Resting heart rate; CRC cis rs1218582 0.772 rs4845693 chr1:154911257 A/G cg03351412 chr1:154909251 PMVK -0.49 -7.56 -0.38 4.17e-13 Prostate cancer; CRC cis rs11676348 0.846 rs7607437 chr2:219008392 A/G cg00012203 chr2:219082015 ARPC2 -0.45 -6.69 -0.35 9.39e-11 Ulcerative colitis; CRC cis rs6502050 0.835 rs7405738 chr17:80084227 A/G cg19223190 chr17:80058835 NA -0.39 -6.24 -0.33 1.31e-9 Life satisfaction; CRC cis rs35110281 0.782 rs1584917 chr21:45042365 A/G cg04455712 chr21:45112962 RRP1B 0.42 8.14 0.41 8.27e-15 Mean corpuscular volume; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg13754859 chr14:24584296 DCAF11 0.5 6.54 0.34 2.3e-10 Thyroid stimulating hormone; CRC cis rs6921919 0.583 rs7773051 chr6:28340316 G/A cg21251018 chr6:28226885 NKAPL 0.4 6.09 0.32 3.12e-9 Autism spectrum disorder or schizophrenia; CRC cis rs1883415 0.552 rs2143083 chr6:24507054 C/T cg20631270 chr6:24437470 GPLD1 0.39 5.9 0.31 8.81e-9 Liver enzyme levels (alkaline phosphatase); CRC trans rs1814175 0.647 rs2903409 chr11:49953612 C/G cg03929089 chr4:120376271 NA -0.74 -12.21 -0.56 1.5e-28 Height; CRC cis rs67311347 0.544 rs9833640 chr3:40354941 T/A cg09455208 chr3:40491958 NA 0.31 6.06 0.32 3.74e-9 Renal cell carcinoma; CRC cis rs9858542 1.000 rs2172252 chr3:49678307 A/T cg03060546 chr3:49711283 APEH -0.52 -7.12 -0.37 6.71e-12 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs6121246 0.567 rs6060249 chr20:30190944 G/A cg13852791 chr20:30311386 BCL2L1 0.6 8.21 0.41 5.04e-15 Mean corpuscular hemoglobin; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg13446153 chr8:41435704 AGPAT6 0.38 6.03 0.32 4.34e-9 Liver disease severity in Alagille syndrome; CRC cis rs992157 0.804 rs7559525 chr2:219150307 A/G cg04731861 chr2:219085781 ARPC2 0.34 6.94 0.36 2.13e-11 Colorectal cancer; CRC cis rs425277 0.606 rs2257684 chr1:2077872 A/G cg04315214 chr1:2043799 PRKCZ -0.39 -6.62 -0.34 1.46e-10 Height; CRC cis rs2274273 0.624 rs11848456 chr14:55755392 A/G cg10130446 chr14:55658398 DLGAP5 -0.41 -5.78 -0.3 1.74e-8 Protein biomarker; CRC cis rs9443189 0.526 rs9359132 chr6:76289553 G/A cg01950844 chr6:76311363 SENP6 0.74 9.8 0.48 4.62e-20 Prostate cancer; CRC cis rs755249 0.567 rs61782157 chr1:39762889 C/T cg18385671 chr1:39797026 MACF1 -0.42 -5.98 -0.31 5.94e-9 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs34311866 0.808 rs62294491 chr4:969111 C/T cg14530993 chr4:882597 GAK 0.75 6.93 0.36 2.17e-11 Parkinson's disease; CRC cis rs2046867 0.862 rs58538718 chr3:72800563 C/A cg25664220 chr3:72788482 NA -0.47 -6.58 -0.34 1.81e-10 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; CRC cis rs863345 0.625 rs10489833 chr1:158490451 C/T cg12129480 chr1:158549410 OR10X1 -0.3 -6.25 -0.33 1.25e-9 Pneumococcal bacteremia; CRC cis rs9733 0.818 rs10888388 chr1:150687296 C/T cg17724175 chr1:150552817 MCL1 -0.46 -7.28 -0.37 2.55e-12 Tonsillectomy; CRC trans rs11098499 0.863 rs1383532 chr4:120434404 A/T cg25214090 chr10:38739885 LOC399744 -0.62 -9.84 -0.48 3.39e-20 Corneal astigmatism; CRC cis rs1865760 1.000 rs7739966 chr6:25906040 T/C cg16482183 chr6:26056742 HIST1H1C 0.54 7.81 0.4 7.71e-14 Height; CRC trans rs7615952 0.512 rs4679430 chr3:125357893 T/C cg16558177 chr4:4109446 NA -0.62 -8.74 -0.43 1.23e-16 Blood pressure (smoking interaction); CRC cis rs6662572 0.906 rs11590549 chr1:46086329 C/T cg08644498 chr1:46502608 NA 0.36 5.87 0.31 1.09e-8 Blood protein levels; CRC cis rs6866344 0.697 rs11748495 chr5:178130000 A/G cg10224037 chr5:178157518 ZNF354A -0.77 -11.4 -0.53 1.35e-25 Neutrophil percentage of white cells; CRC cis rs713477 0.967 rs10150596 chr14:55916167 A/G cg13175173 chr14:55914753 NA 0.53 9.98 0.48 1.11e-20 Pediatric bone mineral content (femoral neck); CRC cis rs5769765 1.000 rs761879 chr22:50241210 G/A cg02269571 chr22:50332266 NA 0.62 8.44 0.42 9.96e-16 Schizophrenia; CRC cis rs7833790 0.963 rs2400473 chr8:82703403 C/T cg17211192 chr8:82754475 SNX16 -0.53 -6.56 -0.34 2.12e-10 Diastolic blood pressure; CRC cis rs9914988 0.725 rs9905510 chr17:27092325 G/A cg07195577 chr17:27052828 TLCD1 0.42 6.03 0.32 4.32e-9 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC trans rs2012709 0.935 rs6879109 chr5:32564547 A/C cg03755955 chr8:6424269 MCPH1 0.43 6.33 0.33 7.9e-10 Breast cancer; CRC cis rs875971 1.000 rs2042133 chr7:65931922 A/G cg18912574 chr7:65842487 NCRNA00174 0.36 6.1 0.32 2.97e-9 Aortic root size; CRC cis rs875971 0.838 rs2173570 chr7:65762963 T/A cg18912574 chr7:65842487 NCRNA00174 -0.36 -6.24 -0.33 1.37e-9 Aortic root size; CRC cis rs12580194 0.593 rs61957924 chr12:55744100 T/C cg23425280 chr12:56401806 NA 0.45 5.72 0.3 2.41e-8 Cancer; CRC cis rs9457247 1.000 rs394522 chr6:167398071 A/C cg23791538 chr6:167370224 RNASET2 -0.38 -5.94 -0.31 7.32e-9 Crohn's disease; CRC cis rs9325144 0.554 rs7960616 chr12:39096664 T/A cg26384229 chr12:38710491 ALG10B -0.51 -7.23 -0.37 3.43e-12 Morning vs. evening chronotype; CRC trans rs875971 0.660 rs2191268 chr7:66110224 C/T cg07739959 chr3:48754206 IP6K2 -0.42 -6.51 -0.34 2.84e-10 Aortic root size; CRC cis rs1707322 0.963 rs12022335 chr1:46402732 C/A cg03146154 chr1:46216737 IPP 0.51 7.09 0.36 8.17e-12 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs12826942 0.765 rs17592014 chr12:42550147 G/A cg11827402 chr12:42719852 PPHLN1;ZCRB1 0.56 6.38 0.33 6.11e-10 Coronary artery disease; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg05747105 chr6:53224391 NA 0.36 6.0 0.31 5.26e-9 Liver disease severity in Alagille syndrome; CRC cis rs67478160 0.654 rs1997913 chr14:104213960 C/T cg08213375 chr14:104286397 PPP1R13B 0.65 13.79 0.61 1.92e-34 Schizophrenia; CRC cis rs611744 0.631 rs681963 chr8:109255032 C/A cg21045802 chr8:109455806 TTC35 0.42 6.68 0.35 1.05e-10 Dupuytren's disease; CRC cis rs7666738 0.830 rs4323111 chr4:98952276 A/G cg05340658 chr4:99064831 C4orf37 0.58 8.95 0.44 2.7e-17 Colonoscopy-negative controls vs population controls; CRC cis rs909002 0.789 rs2139539 chr1:32117779 C/T cg13919466 chr1:32135498 COL16A1 -0.31 -6.0 -0.31 5.09e-9 Intelligence (multi-trait analysis); CRC cis rs2153535 0.580 rs9393021 chr6:8466123 A/G cg21535247 chr6:8435926 SLC35B3 0.5 7.53 0.38 4.89e-13 Motion sickness; CRC cis rs4423214 0.879 rs1790353 chr11:71136730 C/T cg13043300 chr11:71146211 DHCR7 -0.47 -6.39 -0.33 5.76e-10 Vitamin D levels; CRC cis rs758324 0.783 rs253941 chr5:131320293 C/T cg06307176 chr5:131281290 NA -0.4 -5.91 -0.31 8.73e-9 Alzheimer's disease in APOE e4- carriers; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg20754634 chr17:7218651 GPS2 0.4 6.86 0.35 3.47e-11 Liver disease severity in Alagille syndrome; CRC cis rs3741151 0.773 rs73542938 chr11:73103012 G/C cg17517138 chr11:73019481 ARHGEF17 1.03 8.34 0.42 2.05e-15 GIP levels in response to oral glucose tolerance test (120 minutes); CRC cis rs7119 0.717 rs12901732 chr15:77818933 G/T cg27398640 chr15:77910606 LINGO1 -0.44 -7.53 -0.38 4.81e-13 Type 2 diabetes; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg24179850 chr19:56154938 ZNF581 0.39 5.97 0.31 6.16e-9 Intelligence (multi-trait analysis); CRC cis rs7586879 0.964 rs4077679 chr2:25122852 T/C cg22495460 chr2:25135724 ADCY3 -0.72 -11.83 -0.55 3.81e-27 Body mass index; CRC cis rs6570726 0.935 rs1883406 chr6:145823205 A/G cg23711669 chr6:146136114 FBXO30 0.68 12.16 0.56 2.33e-28 Lobe attachment (rater-scored or self-reported); CRC cis rs2361718 0.933 rs8077849 chr17:78104137 C/T cg27427491 chr17:78079615 GAA -0.37 -5.93 -0.31 7.47e-9 Yeast infection; CRC cis rs10504229 0.683 rs56196593 chr8:58141898 G/A cg24829409 chr8:58192753 C8orf71 -0.55 -8.07 -0.41 1.31e-14 Developmental language disorder (linguistic errors); CRC trans rs2303319 0.504 rs1006428 chr2:162592559 A/C cg22677401 chr17:46026860 NA -0.67 -6.07 -0.32 3.57e-9 Cognitive function; CRC cis rs2070677 1.000 rs2515641 chr10:135351362 T/C cg16964102 chr10:135390573 NA -0.49 -6.88 -0.35 3.02e-11 Gout; CRC cis rs7618915 0.547 rs11714419 chr3:52628816 A/G cg11645453 chr3:52864694 ITIH4 0.35 6.07 0.32 3.46e-9 Bipolar disorder; CRC cis rs9393692 0.905 rs9366649 chr6:26329103 A/T cg13736514 chr6:26305472 NA 0.6 11.19 0.53 7.46e-25 Educational attainment; CRC cis rs2120019 0.567 rs8037152 chr15:75156996 A/T cg17294928 chr15:75287854 SCAMP5 -0.55 -6.61 -0.34 1.55e-10 Blood trace element (Zn levels); CRC cis rs41271951 0.512 rs12090246 chr1:151107496 G/A cg11822372 chr1:151115635 SEMA6C -0.72 -5.81 -0.31 1.46e-8 Blood protein levels; CRC cis rs490234 0.871 rs4837019 chr9:128276081 C/G cg14078157 chr9:128172775 NA -0.37 -6.14 -0.32 2.43e-9 Mean arterial pressure; CRC cis rs10504229 0.683 rs16921807 chr8:58105967 C/T cg24829409 chr8:58192753 C8orf71 -0.56 -8.01 -0.4 2.05e-14 Developmental language disorder (linguistic errors); CRC cis rs9435341 0.965 rs2335077 chr1:107573565 A/G cg14828511 chr1:107599125 PRMT6 0.48 7.01 0.36 1.32e-11 Facial morphology (factor 21, depth of nasal alae); CRC cis rs7107770 1.000 rs4936997 chr11:125090227 C/T cg27629782 chr11:125073726 PKNOX2 0.47 5.67 0.3 3.14e-8 Photic sneeze reflex; CRC cis rs2836950 0.565 rs2836926 chr21:40536790 G/A cg11890956 chr21:40555474 PSMG1 -0.65 -9.92 -0.48 1.83e-20 Menarche (age at onset); CRC cis rs72634258 0.945 rs3766606 chr1:8022197 G/T cg00042356 chr1:8021962 PARK7 0.68 8.37 0.42 1.67e-15 Inflammatory bowel disease; CRC cis rs7412746 0.621 rs72704656 chr1:150828307 A/G cg17724175 chr1:150552817 MCL1 0.48 6.93 0.36 2.18e-11 Melanoma; CRC cis rs3087591 0.960 rs2952995 chr17:29541061 T/C cg24425628 chr17:29625626 OMG;NF1 0.87 16.65 0.68 1.46e-45 Hip circumference; CRC cis rs3736485 0.808 rs28485410 chr15:51949885 G/A cg08986416 chr15:51914746 DMXL2 -0.45 -6.36 -0.33 6.88e-10 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs6840360 0.533 rs4696297 chr4:152725838 T/G cg09659197 chr4:152720779 NA -0.43 -8.83 -0.44 6.53e-17 Intelligence (multi-trait analysis); CRC cis rs2949837 0.581 rs1852210 chr7:45994256 C/T cg10677697 chr7:45961126 IGFBP3 0.35 6.14 0.32 2.44e-9 Sitting height ratio; CRC cis rs7772486 0.875 rs9403770 chr6:146423334 C/T cg13319975 chr6:146136371 FBXO30 -0.4 -6.11 -0.32 2.79e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs6933660 0.745 rs9322320 chr6:151751908 C/G cg14416726 chr6:151773293 C6orf211;RMND1 -0.62 -9.35 -0.46 1.34e-18 Menarche (age at onset); CRC trans rs9914544 0.544 rs4244595 chr17:18677329 C/T cg04702396 chr17:15466718 FAM18B2 0.47 7.46 0.38 7.67e-13 Educational attainment (years of education); CRC cis rs10504229 1.000 rs75037501 chr8:58170136 T/G cg22535103 chr8:58192502 C8orf71 -0.82 -12.27 -0.56 9.63e-29 Developmental language disorder (linguistic errors); CRC cis rs8180040 0.676 rs11130114 chr3:47154651 T/G cg27129171 chr3:47204927 SETD2 0.76 13.1 0.59 7.99e-32 Colorectal cancer; CRC cis rs17270561 0.541 rs17586946 chr6:25939053 C/T cg16482183 chr6:26056742 HIST1H1C 1.04 11.72 0.54 9.62e-27 Iron status biomarkers; CRC cis rs6840360 0.967 rs6535812 chr4:152599374 C/A cg09659197 chr4:152720779 NA 0.52 11.2 0.53 7.17e-25 Intelligence (multi-trait analysis); CRC cis rs644799 0.710 rs1852535 chr11:95501241 A/G cg03916912 chr11:95522834 CEP57;FAM76B 0.86 15.59 0.65 2.1e-41 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs561341 1.000 rs497479 chr17:30328605 C/T cg23018236 chr17:30244563 NA -0.65 -7.83 -0.4 6.85e-14 Hip circumference adjusted for BMI; CRC cis rs6424115 1.000 rs1018396 chr1:24133612 G/A cg09473613 chr1:24152604 HMGCL 0.35 6.03 0.32 4.37e-9 Immature fraction of reticulocytes; CRC cis rs875971 0.545 rs6950988 chr7:65976415 C/T cg03233332 chr7:66118400 NA -0.43 -5.96 -0.31 6.51e-9 Aortic root size; CRC trans rs2303319 0.504 rs16845945 chr2:162480684 C/T cg14875682 chr5:52083620 ITGA1;PELO -0.76 -6.18 -0.32 1.94e-9 Cognitive function; CRC cis rs4268898 0.610 rs72791170 chr2:24449776 C/T cg06627628 chr2:24431161 ITSN2 -0.84 -11.53 -0.54 4.77e-26 Asthma; CRC cis rs57221529 0.545 rs55955015 chr5:575182 A/G cg09021430 chr5:549028 NA -0.72 -8.03 -0.4 1.74e-14 Lung disease severity in cystic fibrosis; CRC cis rs1799949 0.965 rs6503726 chr17:41284742 T/C cg25072359 chr17:41440525 NA 0.53 8.34 0.42 2.02e-15 Menopause (age at onset); CRC cis rs8141529 0.719 rs5762880 chr22:29287816 T/G cg15103426 chr22:29168792 CCDC117 0.48 6.66 0.34 1.13e-10 Lymphocyte counts; CRC cis rs5769765 0.908 rs9616370 chr22:50306316 A/G cg22709217 chr22:50311962 ALG12;CRELD2 1.07 17.76 0.7 5.96e-50 Schizophrenia; CRC cis rs231513 0.954 rs231524 chr17:41953212 G/A cg26893861 chr17:41843967 DUSP3 -0.73 -7.37 -0.38 1.37e-12 Cognitive function; CRC cis rs10046574 0.519 rs17403948 chr7:135215169 C/T cg27474649 chr7:135195673 CNOT4 -0.61 -5.8 -0.3 1.56e-8 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs12541635 0.677 rs2029880 chr8:107024649 T/C cg10147462 chr8:107024639 NA 0.58 10.56 0.5 1.24e-22 Age of smoking initiation; CRC cis rs7493 1.000 rs2068604 chr7:95041542 G/T cg04871131 chr7:94954202 PON1 -0.47 -5.77 -0.3 1.81e-8 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs9467711 0.606 rs13203358 chr6:26590578 A/T cg16898833 chr6:26189333 HIST1H4D 0.94 7.7 0.39 1.64e-13 Autism spectrum disorder or schizophrenia; CRC trans rs2797369 0.713 rs9390724 chr6:101521557 G/C cg26346621 chr12:6873348 NA -0.41 -6.12 -0.32 2.68e-9 Renal function-related traits (eGRFcrea); CRC cis rs2732480 0.500 rs12829841 chr12:48628739 A/G cg04545296 chr12:48745243 ZNF641 0.35 6.1 0.32 2.96e-9 Hemoglobin concentration;Red blood cell count;Hematocrit; CRC cis rs4713118 0.587 rs61471148 chr6:28037032 T/A cg15845792 chr6:28175446 NA 0.9 11.93 0.55 1.61e-27 Parkinson's disease; CRC trans rs2303319 0.504 rs62189055 chr2:162625749 C/A cg05865860 chr7:158649142 WDR60 -0.71 -5.97 -0.31 6.26e-9 Cognitive function; CRC cis rs853679 0.517 rs11552219 chr6:28126834 C/T cg23161317 chr6:28129485 ZNF389 0.53 6.43 0.33 4.52e-10 Depression; CRC cis rs11711311 1.000 rs28394480 chr3:113485143 T/C cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.51 -6.92 -0.36 2.41e-11 IgG glycosylation; CRC trans rs3749237 0.964 rs2352967 chr3:49871641 C/T cg21665057 chr3:196295764 WDR53;FBXO45 0.55 7.89 0.4 4.39e-14 Resting heart rate; CRC cis rs950776 0.518 rs4887062 chr15:78837801 G/A cg06917634 chr15:78832804 PSMA4 -0.66 -10.54 -0.5 1.38e-22 Sudden cardiac arrest; CRC trans rs561341 0.883 rs886224 chr17:30229902 T/C cg20587970 chr11:113659929 NA -1.03 -12.4 -0.56 3.16e-29 Hip circumference adjusted for BMI; CRC trans rs7180079 0.925 rs11071789 chr15:64596057 C/T cg22857141 chr5:123707481 NA 0.48 6.09 0.32 3.14e-9 Monocyte count; CRC cis rs853679 0.517 rs1947863 chr6:28099344 G/A cg12172441 chr6:28176163 NA 0.62 7.4 0.38 1.17e-12 Depression; CRC cis rs8141797 0.901 rs176157 chr22:24503987 C/T cg20894457 chr22:24584366 SUSD2 0.62 7.52 0.38 5.37e-13 Amyotrophic lateral sclerosis;Coronary artery disease; CRC cis rs17270561 0.609 rs9358886 chr6:25758253 T/A cg16482183 chr6:26056742 HIST1H1C 0.85 10.72 0.51 3.37e-23 Iron status biomarkers; CRC cis rs73206853 0.563 rs73194046 chr12:111191665 A/G cg12870014 chr12:110450643 ANKRD13A 0.73 8.56 0.43 4.32e-16 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC cis rs3741404 0.825 rs11603384 chr11:63949095 G/A cg04317338 chr11:64019027 PLCB3 0.42 5.8 0.3 1.58e-8 Platelet count; CRC cis rs11958404 0.932 rs72816550 chr5:157418457 A/T cg05962755 chr5:157440814 NA 0.76 10.43 0.5 3.33e-22 IgG glycosylation; CRC cis rs4713118 0.868 rs742047 chr6:27739380 A/G cg25164649 chr6:28176230 NA 0.7 7.93 0.4 3.42e-14 Parkinson's disease; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg11991806 chr6:112408804 TUBE1;C6orf225 0.53 7.93 0.4 3.51e-14 Intelligence (multi-trait analysis); CRC cis rs909674 0.524 rs5750821 chr22:39825492 A/T cg05872129 chr22:39784769 NA -0.61 -11.93 -0.55 1.58e-27 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; CRC trans rs4332037 0.539 rs11763750 chr7:2080114 G/A cg11693508 chr17:37793320 STARD3 0.63 7.47 0.38 7.06e-13 Bipolar disorder; CRC cis rs4776997 0.559 rs12902904 chr15:68076533 G/A cg08154944 chr15:67813145 C15orf61 -0.44 -5.66 -0.3 3.23e-8 Verbal declarative memory; CRC cis rs7605827 0.856 rs35549453 chr2:15527220 C/T cg19274914 chr2:15703543 NA 0.39 5.87 0.31 1.05e-8 Educational attainment (years of education); CRC cis rs4713118 0.591 rs2056924 chr6:27690174 G/A cg26587870 chr6:27730563 NA -0.36 -5.76 -0.3 1.97e-8 Parkinson's disease; CRC cis rs6502050 0.835 rs8066284 chr17:80127825 C/T cg02741985 chr17:80059408 CCDC57 0.44 7.24 0.37 3.25e-12 Life satisfaction; CRC cis rs365302 0.716 rs452651 chr6:159610946 C/T cg14500486 chr6:159655392 FNDC1 0.52 7.91 0.4 3.92e-14 Coronary heart disease; CRC cis rs10242455 1.000 rs6948775 chr7:98945480 A/G cg18809830 chr7:99032528 PTCD1 -0.75 -6.5 -0.34 2.96e-10 Blood metabolite levels; CRC cis rs67614146 1 rs67614146 chr6:87821827 AC/A cg04972856 chr6:88032051 C6orf162;GJB7 -0.34 -6.18 -0.32 1.84e-9 Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg03402775 chr3:108308147 DZIP3;KIAA1524 0.44 6.31 0.33 8.87e-10 Intelligence (multi-trait analysis); CRC trans rs17507216 0.718 rs4779033 chr15:83245384 C/T cg02798295 chr19:804596 PTBP1 0.43 6.04 0.32 4.22e-9 Excessive daytime sleepiness; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg23609821 chr14:20937494 PNP 0.48 6.97 0.36 1.79e-11 Intelligence (multi-trait analysis); CRC cis rs11229555 0.645 rs34530191 chr11:58200854 A/G cg15696309 chr11:58395628 NA -0.9 -11.45 -0.53 8.8e-26 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; CRC cis rs72615157 0.613 rs56089143 chr7:99819844 G/A cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.46 5.83 0.31 1.32e-8 Lung function (FEV1/FVC); CRC cis rs7833986 0.501 rs2953922 chr8:56977485 G/A cg23139584 chr8:56987506 RPS20;SNORD54 0.91 12.57 0.57 7.49e-30 Height; CRC cis rs4588572 0.643 rs1019803 chr5:77739154 A/G cg11446398 chr5:77624930 NA 0.44 5.83 0.31 1.29e-8 Triglycerides; CRC cis rs7916697 0.626 rs61854803 chr10:70014638 T/C cg06988349 chr10:69991859 ATOH7 0.39 7.29 0.37 2.26e-12 Optic disc area; CRC cis rs2228479 0.867 rs11645970 chr16:89958118 G/A cg12064134 chr16:90016061 DEF8 -0.62 -5.62 -0.3 4.11e-8 Skin colour saturation; CRC cis rs9549367 0.789 rs9604040 chr13:113910611 A/G cg00898013 chr13:113819073 PROZ 0.44 6.54 0.34 2.31e-10 Platelet distribution width; CRC cis rs117623576 0.680 rs11008756 chr10:32363137 A/G cg03047570 chr10:32398778 NA -0.63 -7.0 -0.36 1.46e-11 Anti-saccade response; CRC cis rs270601 0.739 rs1979981 chr5:131601720 G/A cg02033258 chr5:131593261 PDLIM4 0.46 8.66 0.43 2.08e-16 Acylcarnitine levels; CRC cis rs6570726 0.967 rs374728 chr6:145854598 T/A cg23711669 chr6:146136114 FBXO30 0.7 12.47 0.57 1.65e-29 Lobe attachment (rater-scored or self-reported); CRC cis rs853679 0.517 rs868987 chr6:28110148 A/G cg02631126 chr6:28058918 ZSCAN12L1 -0.29 -5.94 -0.31 7.3e-9 Depression; CRC cis rs2637266 0.561 rs11001867 chr10:78491455 A/T cg18941641 chr10:78392320 NA 0.35 5.91 0.31 8.47e-9 Pulmonary function; CRC cis rs748404 0.660 rs2249952 chr15:43720533 G/C cg02155558 chr15:43621948 ADAL;LCMT2 0.53 7.88 0.4 4.67e-14 Lung cancer; CRC cis rs6424115 0.800 rs2229581 chr1:24201094 G/C cg15997130 chr1:24165203 NA 0.73 10.74 0.51 2.79e-23 Immature fraction of reticulocytes; CRC cis rs28374715 0.532 rs316607 chr15:41772693 G/A cg18705301 chr15:41695430 NDUFAF1 -1.12 -19.25 -0.73 7.48e-56 Ulcerative colitis; CRC cis rs7843479 0.601 rs10101881 chr8:21830158 A/G cg16476235 chr8:21771668 DOK2 0.38 6.24 0.33 1.33e-9 Mean corpuscular volume; CRC cis rs10206020 0.885 rs11887527 chr2:1578080 A/G cg12573674 chr2:1569213 NA -0.77 -10.15 -0.49 3.03e-21 IgG glycosylation; CRC cis rs6988985 0.693 rs10093796 chr8:143978424 T/C cg10324643 chr8:143916377 GML 0.38 6.27 0.33 1.15e-9 Plasma androstenedione levels in resected early stage-receptor positive breast cancer; CRC cis rs4909189 1.000 rs4909189 chr7:158136986 A/T cg06219351 chr7:158114137 PTPRN2 0.58 8.49 0.42 7.02e-16 Response to amphetamines; CRC cis rs12893668 0.572 rs4906350 chr14:104111794 C/T cg08213375 chr14:104286397 PPP1R13B 0.43 6.81 0.35 4.57e-11 Reticulocyte count; CRC cis rs2742417 0.967 rs2742462 chr3:45774696 G/A cg04837898 chr3:45731254 SACM1L -0.34 -5.63 -0.3 3.86e-8 Response to anti-depressant treatment in major depressive disorder; CRC trans rs7615952 0.512 rs2979336 chr3:125357470 G/A cg07211511 chr3:129823064 LOC729375 -0.63 -8.74 -0.43 1.17e-16 Blood pressure (smoking interaction); CRC cis rs2486012 0.678 rs2906460 chr1:44335323 A/G cg12908607 chr1:44402522 ARTN -0.42 -5.77 -0.3 1.81e-8 Intelligence (multi-trait analysis); CRC cis rs10540 0.841 rs35601764 chr11:532923 A/C cg21784768 chr11:537496 LRRC56 -0.72 -6.87 -0.35 3.26e-11 Body mass index; CRC cis rs6951245 1.000 rs78861357 chr7:1095418 C/T cg22907277 chr7:1156413 C7orf50 0.72 7.6 0.39 3.1400000000000003e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs2933343 0.729 rs813945 chr3:128660937 A/G cg11901034 chr3:128598214 ACAD9 -0.57 -8.16 -0.41 7.15e-15 IgG glycosylation; CRC cis rs7772486 0.790 rs2249147 chr6:146184999 T/C cg13319975 chr6:146136371 FBXO30 -0.43 -6.45 -0.34 3.93e-10 Lobe attachment (rater-scored or self-reported); CRC cis rs1656402 1.000 rs1729254 chr2:233428809 A/G cg03852847 chr2:233439513 NA 0.44 7.56 0.38 4.08e-13 Non-small cell lung cancer (survival); CRC cis rs17001868 0.568 rs742140 chr22:40781586 G/A cg07138101 chr22:40742427 ADSL 0.55 7.16 0.37 5.31e-12 Mammographic density (dense area); CRC cis rs7107174 1.000 rs2512533 chr11:77968674 A/C cg02023728 chr11:77925099 USP35 0.53 7.5 0.38 6.19e-13 Testicular germ cell tumor; CRC cis rs995000 0.929 rs2029763 chr1:63013134 A/G cg19896129 chr1:63156450 NA 0.4 5.78 0.3 1.76e-8 Triglyceride levels; CRC trans rs1005277 0.579 rs11011461 chr10:38431427 G/A cg23533926 chr12:111358616 MYL2 -0.53 -7.97 -0.4 2.56e-14 Extrinsic epigenetic age acceleration; CRC cis rs79387448 0.745 rs17027496 chr2:103178223 T/A cg09003973 chr2:102972529 NA 0.72 7.67 0.39 1.94e-13 Gut microbiota (bacterial taxa); CRC cis rs7918232 0.941 rs1753413 chr10:27397112 T/C cg14240646 chr10:27532245 ACBD5 -0.82 -9.19 -0.45 4.62e-18 Breast cancer; CRC cis rs9443645 0.901 rs2050660 chr6:79734726 C/T cg11833968 chr6:79620685 NA -0.37 -6.33 -0.33 7.99e-10 Intelligence (multi-trait analysis); CRC cis rs11148252 0.740 rs9596642 chr13:52900879 A/G cg02158880 chr13:53174818 NA -0.44 -6.34 -0.33 7.44e-10 Lewy body disease; CRC cis rs6694672 0.618 rs10429911 chr1:197146144 A/C cg13682187 chr1:196946512 CFHR5 0.44 7.04 0.36 1.11e-11 Asthma; CRC cis rs12477438 0.520 rs13009147 chr2:99803998 T/G cg26064155 chr2:99771622 LIPT1;TSGA10 0.87 15.69 0.65 8.34e-42 Chronic sinus infection; CRC cis rs6893807 1.000 rs1422191 chr5:87949158 G/A cg09002922 chr5:87956389 LOC645323 -0.45 -6.53 -0.34 2.5e-10 Body mass index; CRC cis rs7666738 0.830 rs4699591 chr4:98974171 A/G cg05340658 chr4:99064831 C4orf37 0.6 9.35 0.46 1.41e-18 Colonoscopy-negative controls vs population controls; CRC cis rs1005277 0.541 rs2472177 chr10:38384015 T/G cg25427524 chr10:38739819 LOC399744 -0.77 -14.06 -0.61 1.67e-35 Extrinsic epigenetic age acceleration; CRC cis rs9926296 0.585 rs8045232 chr16:89857548 A/G cg27121462 chr16:89883253 FANCA 0.58 9.27 0.45 2.57e-18 Vitiligo; CRC cis rs4692589 0.581 rs34149802 chr4:170960284 A/G cg19918862 chr4:170955249 NA 0.52 7.0 0.36 1.48e-11 Anxiety disorder; CRC cis rs11039131 0.629 rs67871383 chr11:47335838 T/C cg05585544 chr11:47624801 NA -0.4 -6.5 -0.34 3.01e-10 Schizophrenia; CRC cis rs10089 0.552 rs17607942 chr5:127555435 C/T cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.62 7.52 0.38 5.14e-13 Ileal carcinoids; CRC cis rs5753618 0.561 rs2413049 chr22:31686144 A/G cg07713946 chr22:31675144 LIMK2 -0.39 -5.64 -0.3 3.6e-8 Colorectal cancer; CRC cis rs453301 0.686 rs13252797 chr8:8861430 A/G cg06636001 chr8:8085503 FLJ10661 0.53 7.91 0.4 3.85e-14 Joint mobility (Beighton score); CRC cis rs72781680 0.611 rs7602797 chr2:24318148 C/T cg20701182 chr2:24300061 SF3B14 0.61 7.25 0.37 3.03e-12 Lymphocyte counts; CRC cis rs11997175 0.646 rs66856932 chr8:33700782 A/G cg04338863 chr8:33670619 NA 0.42 6.65 0.34 1.21e-10 Body mass index; CRC trans rs7395662 0.892 rs9667579 chr11:48730148 C/T cg21153622 chr11:89784906 NA 0.46 7.41 0.38 1.06e-12 HDL cholesterol; CRC cis rs875971 0.964 rs160635 chr7:65528918 T/C cg00343986 chr7:65444356 GUSB 0.44 6.54 0.34 2.37e-10 Aortic root size; CRC cis rs2120019 1.000 rs8036197 chr15:75370232 T/C cg11632617 chr15:75315747 PPCDC -0.56 -7.96 -0.4 2.86e-14 Blood trace element (Zn levels); CRC cis rs10504229 0.639 rs66667899 chr8:58117065 C/T cg02290350 chr8:58132656 NA -0.58 -8.16 -0.41 7.29e-15 Developmental language disorder (linguistic errors); CRC cis rs13395090 0.606 rs13405419 chr2:3720664 T/C cg19052272 chr2:3704530 ALLC -0.41 -5.61 -0.3 4.2e-8 Response to inhaled corticosteroid treatment in asthma (change in FEV1); CRC cis rs55823223 0.564 rs12103594 chr17:73855279 C/T cg24416660 chr17:73865998 NA -0.4 -6.08 -0.32 3.34e-9 Psoriasis; CRC cis rs4319547 0.695 rs12314643 chr12:122917423 C/T cg05707623 chr12:122985044 ZCCHC8 -0.61 -7.86 -0.4 5.6e-14 Body mass index; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg18752785 chr20:3996394 RNF24 0.46 7.26 0.37 2.72e-12 Liver disease severity in Alagille syndrome; CRC trans rs7142881 0.604 rs6571468 chr14:32288862 G/A cg26207357 chr2:190539199 NA 0.39 5.96 0.31 6.33e-9 Response to iloperidone treatment (QT prolongation); CRC cis rs425277 0.606 rs2459984 chr1:2086312 A/G cg24578937 chr1:2090814 PRKCZ 0.37 6.85 0.35 3.71e-11 Height; CRC cis rs11098499 0.779 rs80242894 chr4:120375752 G/A cg09307838 chr4:120376055 NA 0.71 11.05 0.52 2.34e-24 Corneal astigmatism; CRC cis rs10504229 0.683 rs2101864 chr8:58113226 C/T cg24829409 chr8:58192753 C8orf71 -0.55 -7.9 -0.4 4.11e-14 Developmental language disorder (linguistic errors); CRC cis rs13118159 0.509 rs4974554 chr4:1356967 A/C cg02475777 chr4:1388615 CRIPAK 0.51 6.53 0.34 2.53e-10 Longevity; CRC cis rs763121 0.853 rs138706 chr22:39137834 C/G cg06544989 chr22:39130855 UNC84B 0.48 7.39 0.38 1.2e-12 Menopause (age at onset); CRC cis rs1799949 1.000 rs34942571 chr17:41273379 G/C cg05368731 chr17:41323189 NBR1 0.65 9.55 0.47 3.16e-19 Menopause (age at onset); CRC trans rs800082 0.839 rs62275528 chr3:144293687 T/C cg24215973 chr2:240111563 HDAC4 -0.53 -6.82 -0.35 4.32e-11 Smoking behavior; CRC cis rs600806 0.850 rs4970751 chr1:109896600 A/C cg23032129 chr1:109941072 SORT1 -0.28 -6.01 -0.31 5.02e-9 Intelligence (multi-trait analysis); CRC cis rs28829049 0.508 rs4578242 chr1:19391565 G/C cg13387374 chr1:19411106 UBR4 0.42 6.06 0.32 3.66e-9 QRS duration in Tripanosoma cruzi seropositivity; CRC cis rs5750830 0.594 rs1010170 chr22:39778327 C/T cg05872129 chr22:39784769 NA 0.62 10.09 0.49 5.02e-21 Intelligence (multi-trait analysis); CRC cis rs4588572 0.644 rs7714871 chr5:77754268 G/T cg11547950 chr5:77652471 NA -0.52 -7.42 -0.38 1.01e-12 Triglycerides; CRC cis rs875971 0.862 rs6944374 chr7:65686929 C/G cg18876405 chr7:65276391 NA -0.56 -8.93 -0.44 3.09e-17 Aortic root size; CRC cis rs929354 0.742 rs2107863 chr7:156963731 T/C cg05182265 chr7:156933206 UBE3C -0.76 -14.38 -0.62 1.04e-36 Body mass index; CRC cis rs10504229 0.728 rs17804822 chr8:58156276 T/C cg08219700 chr8:58056026 NA 0.45 5.64 0.3 3.58e-8 Developmental language disorder (linguistic errors); CRC trans rs9341835 0.584 rs2096346 chr6:64153014 T/C cg13657004 chr13:50234944 EBPL -0.37 -6.38 -0.33 6.03e-10 Schizophrenia; CRC cis rs6461049 0.800 rs1860831 chr7:2160931 T/C cg08027265 chr7:2291960 NA -0.37 -6.36 -0.33 6.64e-10 Schizophrenia; CRC cis rs1862618 0.853 rs832553 chr5:56114786 A/G cg20203395 chr5:56204925 C5orf35 -0.67 -8.03 -0.41 1.69e-14 Initial pursuit acceleration; CRC cis rs7208859 0.573 rs73277974 chr17:29189869 A/G cg01831904 chr17:28903510 LRRC37B2 -0.55 -5.77 -0.3 1.88e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs1799949 1.000 rs8176234 chr17:41219780 T/C cg01879757 chr17:41196368 BRCA1 -0.43 -6.53 -0.34 2.56e-10 Menopause (age at onset); CRC cis rs7772486 0.754 rs9373476 chr6:146139741 C/G cg05347473 chr6:146136440 FBXO30 0.4 6.04 0.32 4.13e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs2721195 1.000 rs11542372 chr8:145677089 G/A cg17328964 chr8:145687451 CYHR1 0.68 12.22 0.56 1.5e-28 Age at first birth; CRC cis rs2976388 0.609 rs1594999 chr8:143790574 G/A cg05569086 chr8:143859399 LYNX1 0.4 6.98 0.36 1.68e-11 Urinary tract infection frequency; CRC trans rs875971 0.545 rs2420456 chr7:65745606 T/G cg02869306 chr7:64672164 INTS4L1 -0.45 -6.64 -0.34 1.26e-10 Aortic root size; CRC cis rs10905065 0.895 rs3736462 chr10:5804455 A/G cg11519256 chr10:5708881 ASB13 0.51 7.42 0.38 1.03e-12 Menopause (age at onset); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg10200477 chr1:87801011 LMO4 0.39 6.7 0.35 9.03e-11 Liver disease severity in Alagille syndrome; CRC cis rs9322193 0.516 rs1999632 chr6:150187873 C/T cg13206674 chr6:150067644 NUP43 0.54 6.68 0.35 1.02e-10 Lung cancer; CRC trans rs3008870 0.583 rs2147838 chr1:67399466 T/C cg01448155 chr10:3564782 NA -0.5 -6.09 -0.32 3.23e-9 Lymphocyte percentage of white cells; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg06391107 chr19:40502439 ZNF546 0.48 6.12 0.32 2.63e-9 Thyroid stimulating hormone; CRC cis rs2153535 0.541 rs9505456 chr6:8479001 T/C cg07606381 chr6:8435919 SLC35B3 0.67 10.78 0.51 2.07e-23 Motion sickness; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg21052403 chr11:320889 IFITM3 0.42 6.75 0.35 6.56e-11 Liver disease severity in Alagille syndrome; CRC cis rs8014204 0.935 rs8010840 chr14:75355203 T/C cg03030879 chr14:75389066 RPS6KL1 0.56 9.01 0.45 1.66e-17 Caffeine consumption; CRC cis rs6502050 1.000 rs6502050 chr17:80058236 C/G cg22110888 chr17:80059540 CCDC57 -0.45 -7.15 -0.37 5.78e-12 Life satisfaction; CRC cis rs4970988 0.501 rs11204713 chr1:150694623 T/A cg18016565 chr1:150552671 MCL1 0.46 6.63 0.34 1.39e-10 Urate levels; CRC cis rs1799949 1.000 rs8176234 chr17:41219780 T/C cg05368731 chr17:41323189 NBR1 0.68 10.22 0.49 1.81e-21 Menopause (age at onset); CRC cis rs3820068 0.532 rs72647105 chr1:15935238 C/G cg24675056 chr1:15929824 NA 0.5 6.85 0.35 3.58e-11 Systolic blood pressure; CRC cis rs9326248 0.773 rs1060211 chr11:117039797 G/A cg26566898 chr11:117069891 TAGLN 0.39 6.96 0.36 1.85e-11 Blood protein levels; CRC cis rs35110281 0.744 rs230645 chr21:44918607 A/G cg01579765 chr21:45077557 HSF2BP 0.36 6.65 0.34 1.26e-10 Mean corpuscular volume; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg18724032 chr3:171758176 FNDC3B 0.37 6.73 0.35 7.44e-11 Liver disease severity in Alagille syndrome; CRC cis rs875971 0.830 rs6950137 chr7:65976610 G/A cg00343986 chr7:65444356 GUSB 0.42 6.0 0.31 5.24e-9 Aortic root size; CRC cis rs9916302 0.904 rs8065963 chr17:37681332 C/T cg03013999 chr17:37608204 MED1 0.46 7.04 0.36 1.15e-11 Glomerular filtration rate (creatinine); CRC cis rs10504229 0.639 rs67002486 chr8:58117218 A/G cg02725872 chr8:58115012 NA -0.64 -11.55 -0.54 3.85e-26 Developmental language disorder (linguistic errors); CRC cis rs916888 0.610 rs199536 chr17:44820425 T/C cg01570182 chr17:44337453 NA -0.72 -9.26 -0.45 2.71e-18 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs9487051 0.872 rs6924815 chr6:109612344 A/G cg12927641 chr6:109611667 NA -0.37 -6.72 -0.35 8.01e-11 Reticulocyte fraction of red cells; CRC cis rs6076065 0.723 rs2424530 chr20:23369354 A/G cg11657817 chr20:23433608 CST11 0.45 6.68 0.35 1.02e-10 Facial morphology (factor 15, philtrum width); CRC cis rs10979 0.597 rs9484776 chr6:143906325 T/C cg25407410 chr6:143891975 LOC285740 -0.66 -8.69 -0.43 1.76e-16 Hypospadias; CRC cis rs4930103 0.782 rs10840167 chr11:2022023 G/T cg23202291 chr11:1979235 NA 0.46 6.34 0.33 7.74e-10 DNA methylation (parent-of-origin);DNA methylation (variation); CRC cis rs12497850 0.931 rs9846123 chr3:49088112 C/T cg20833759 chr3:49053208 WDR6;DALRD3 -0.49 -8.31 -0.42 2.55e-15 Parkinson's disease; CRC cis rs1218582 0.741 rs2335407 chr1:154843347 A/G cg06221963 chr1:154839813 KCNN3 0.81 16.95 0.68 9.06e-47 Prostate cancer; CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg16333535 chr22:24093440 ZNF70 -0.54 -6.64 -0.34 1.27e-10 Diisocyanate-induced asthma; CRC cis rs6951245 1.000 rs74366004 chr7:1088630 A/C cg26224354 chr7:1096374 C7orf50;GPR146 -0.94 -11.87 -0.55 2.79e-27 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs4727027 0.870 rs1568945 chr7:148874112 T/G cg23583168 chr7:148888333 NA -0.86 -14.56 -0.63 2.12e-37 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC cis rs17270561 0.636 rs9358880 chr6:25743161 C/T cg16482183 chr6:26056742 HIST1H1C 0.83 10.69 0.51 4.46e-23 Iron status biomarkers; CRC cis rs877282 0.945 rs877280 chr10:771599 C/T cg06581033 chr10:766294 NA -0.5 -5.73 -0.3 2.28e-8 Uric acid levels; CRC cis rs72772090 0.539 rs56213813 chr5:96112284 A/T cg17330273 chr5:96107758 CAST;ERAP1 -0.66 -6.04 -0.32 4.12e-9 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC trans rs8073060 0.586 rs4795086 chr17:34042190 G/A cg19694781 chr19:47549865 TMEM160 1.08 14.83 0.63 1.78e-38 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; CRC cis rs6969780 1.000 rs1548497 chr7:27174316 A/G cg26364809 chr7:27145159 NA 0.69 6.63 0.34 1.36e-10 Diastolic blood pressure;Blood pressure traits (multi-trait analysis);Systolic blood pressure;Hypertension; CRC cis rs1904096 0.506 rs13435702 chr4:95167751 G/A cg11021082 chr4:95130006 SMARCAD1 -0.58 -9.18 -0.45 4.85e-18 Type 2 diabetes; CRC cis rs6918586 0.658 rs198854 chr6:26104057 T/C cg18357526 chr6:26021779 HIST1H4A -0.49 -7.4 -0.38 1.16e-12 Schizophrenia; CRC cis rs7178572 0.889 rs907388 chr15:77828668 G/A cg22256960 chr15:77711686 NA -0.61 -8.55 -0.43 4.74e-16 Type 2 diabetes; CRC cis rs6693567 0.565 rs1694379 chr1:150292417 C/A cg04165759 chr1:150448943 RPRD2 0.36 5.92 0.31 7.88e-9 Migraine; CRC cis rs9322193 0.607 rs10457852 chr6:150201720 C/T cg07701084 chr6:150067640 NUP43 0.48 6.01 0.31 4.92e-9 Lung cancer; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg23932593 chr6:133135524 RPS12;SNORD101 -0.41 -6.07 -0.32 3.46e-9 Myopia (pathological); CRC trans rs2797160 0.935 rs12717178 chr6:126016499 G/A cg05039488 chr6:79577232 IRAK1BP1 0.5 7.48 0.38 6.77e-13 Endometrial cancer; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg18382341 chr1:230778080 COG2 0.43 6.07 0.32 3.51e-9 Anxiety disorder; CRC cis rs11249608 0.548 rs62393072 chr5:178450056 C/T cg01312482 chr5:178451176 ZNF879 -0.36 -5.98 -0.31 5.94e-9 Pubertal anthropometrics; CRC cis rs7945705 0.747 rs2653605 chr11:8993309 C/G cg00186954 chr11:8933980 ST5;C11orf17 -0.44 -7.73 -0.39 1.32e-13 Hemoglobin concentration; CRC cis rs9311474 0.607 rs11711421 chr3:52561779 C/T cg13284614 chr3:52569169 NT5DC2;LOC440957 0.35 5.61 0.3 4.39e-8 Electroencephalogram traits; CRC cis rs17270561 0.609 rs7754733 chr6:25745049 C/G cg17691542 chr6:26056736 HIST1H1C 0.72 9.24 0.45 3.07e-18 Iron status biomarkers; CRC cis rs2404602 0.619 rs7342603 chr15:76982625 C/T cg23625390 chr15:77176239 SCAPER 0.5 7.35 0.38 1.63e-12 Blood metabolite levels; CRC cis rs2243480 0.803 rs34004500 chr7:65312178 A/T cg18252515 chr7:66147081 NA -1.17 -13.57 -0.6 1.26e-33 Diabetic kidney disease; CRC cis rs9914988 0.943 rs9907178 chr17:27124307 G/C cg16670446 chr17:27188758 MIR451;MIR144 0.55 8.52 0.43 5.75e-16 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs8010715 0.848 rs2277483 chr14:24591892 A/G cg23112188 chr14:24563095 PCK2 -0.36 -6.92 -0.36 2.33e-11 IgG glycosylation; CRC cis rs600231 0.683 rs588298 chr11:65253574 A/G cg17120908 chr11:65337727 SSSCA1 -0.59 -9.0 -0.44 1.85e-17 Bone mineral density; CRC cis rs116095464 0.558 rs6555058 chr5:226376 C/T cg22857025 chr5:266934 NA 1.21 16.75 0.68 5.5e-46 Breast cancer; CRC cis rs11098499 0.863 rs1552092 chr4:120488496 C/T cg09307838 chr4:120376055 NA 0.67 10.02 0.48 8.25e-21 Corneal astigmatism; CRC cis rs9372498 0.536 rs9489442 chr6:118885950 A/C cg18833306 chr6:118973337 C6orf204 0.45 5.95 0.31 6.95e-9 Diastolic blood pressure; CRC cis rs9292777 0.777 rs56284872 chr5:40392384 A/G cg09067459 chr5:40385259 NA -0.57 -9.39 -0.46 1.05e-18 Crohn's disease;Multiple sclerosis; CRC trans rs2228479 0.618 rs17233623 chr16:89811209 C/T cg21302420 chr1:112162376 RAP1A 0.67 6.0 0.31 5.08e-9 Skin colour saturation; CRC cis rs853679 0.517 rs9357061 chr6:28051772 A/G cg18032046 chr6:28092343 ZSCAN16 -0.5 -5.94 -0.31 7.43e-9 Depression; CRC trans rs10021731 0.692 rs10516602 chr4:115407330 C/T cg25927708 chr2:119603813 EN1 -0.32 -5.96 -0.31 6.5e-9 Optic disc area; CRC cis rs4713118 0.869 rs7776351 chr6:27726731 A/G cg15845792 chr6:28175446 NA -0.66 -9.21 -0.45 3.96e-18 Parkinson's disease; CRC cis rs11971779 0.680 rs6949599 chr7:139054188 A/G cg23387468 chr7:139079360 LUC7L2 0.41 7.04 0.36 1.14e-11 Diisocyanate-induced asthma; CRC cis rs4665809 1.000 rs6546767 chr2:26328746 A/G cg25036284 chr2:26402008 FAM59B -0.45 -5.86 -0.31 1.14e-8 Gut microbiome composition (summer); CRC cis rs2404602 1.000 rs4886818 chr15:76880939 G/A cg23625390 chr15:77176239 SCAPER 0.58 8.75 0.43 1.1e-16 Blood metabolite levels; CRC cis rs2708977 0.637 rs618454 chr2:97080093 C/G cg23100626 chr2:96804247 ASTL 0.23 6.0 0.31 5.34e-9 Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes; CRC cis rs10752881 1.000 rs12028732 chr1:182985525 G/C ch.1.3577855R chr1:183094577 LAMC1 0.86 15.22 0.64 5.91e-40 Colorectal cancer; CRC cis rs12545109 0.800 rs1561224 chr8:57419922 T/C cg09654669 chr8:57350985 NA -0.45 -7.22 -0.37 3.74e-12 Obesity-related traits; CRC cis rs7927771 0.931 rs4752801 chr11:47907641 A/G cg18512352 chr11:47633146 NA -0.42 -8.39 -0.42 1.41e-15 Subjective well-being; CRC cis rs10751667 0.666 rs11246357 chr11:963980 A/C ch.11.42038R chr11:967971 AP2A2 0.55 9.42 0.46 8.52e-19 Alzheimer's disease (late onset); CRC cis rs7044106 0.791 rs10985009 chr9:123493039 C/T cg14255062 chr9:123606675 PSMD5;LOC253039 -0.47 -7.13 -0.37 6.38e-12 Hip circumference adjusted for BMI; CRC cis rs1552244 0.572 rs7645667 chr3:10157337 C/A cg02579736 chr3:10068473 FANCD2;CIDECP 1.04 11.71 0.54 1.07e-26 Alzheimer's disease; CRC cis rs8141529 0.748 rs5762874 chr22:29269658 C/G cg02153584 chr22:29168773 CCDC117 0.48 6.94 0.36 2.03e-11 Lymphocyte counts; CRC cis rs11969893 0.649 rs9485415 chr6:101279459 C/T cg12253828 chr6:101329408 ASCC3 0.8 7.12 0.37 6.76e-12 Economic and political preferences (immigration/crime); CRC cis rs3733585 0.673 rs9993410 chr4:9951264 C/T cg11266682 chr4:10021025 SLC2A9 -0.48 -9.58 -0.47 2.4e-19 Cleft plate (environmental tobacco smoke interaction); CRC cis rs12692738 0.526 rs355826 chr2:165612355 A/C cg03182029 chr2:165697222 COBLL1 0.5 5.9 0.31 8.88e-9 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);Waist-to-hip ratio adjusted for BMI in non-smokers;Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction);Waist-to-hip ratio adjusted for body mass index; CRC cis rs4862750 0.957 rs4861733 chr4:187903933 C/T cg10295955 chr4:187884368 NA -1.06 -25.45 -0.81 9.94e-80 Lobe attachment (rater-scored or self-reported); CRC cis rs7605827 0.897 rs12692274 chr2:15707711 A/G cg19274914 chr2:15703543 NA 0.4 6.12 0.32 2.62e-9 Educational attainment (years of education); CRC cis rs9858542 0.953 rs7623659 chr3:49414791 C/T cg07274523 chr3:49395745 GPX1 0.45 6.05 0.32 4.03e-9 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs7586879 0.521 rs7597332 chr2:25075675 A/G cg22495460 chr2:25135724 ADCY3 -0.78 -14.34 -0.62 1.43e-36 Body mass index; CRC cis rs76878669 0.561 rs1784029 chr11:66099987 C/T cg18002602 chr11:66138449 SLC29A2 0.26 5.73 0.3 2.28e-8 Educational attainment (years of education); CRC cis rs6951245 0.872 rs75280240 chr7:1058511 C/T cg26224354 chr7:1096374 C7orf50;GPR146 -0.85 -10.69 -0.51 4.28e-23 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs7773004 1.000 rs7773004 chr6:26267755 A/G cg00631329 chr6:26305371 NA -0.43 -7.26 -0.37 2.83e-12 Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for body mass index;Waist circumference adjusted for BMI in non-smokers;Waist circumference adjusted for BMI (adjusted for smoking behaviour); CRC cis rs9549367 0.756 rs3861723 chr13:113910926 A/G cg00898013 chr13:113819073 PROZ -0.41 -6.22 -0.32 1.53e-9 Platelet distribution width; CRC cis rs1348850 0.519 rs1527407 chr2:178525630 T/G cg02961200 chr2:178257176 LOC100130691;AGPS 0.52 7.25 0.37 2.95e-12 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC trans rs6951245 1.000 rs76129108 chr7:1089159 G/A cg13565492 chr6:43139072 SRF -0.71 -7.12 -0.37 7.03e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC trans rs6546324 0.625 rs4671813 chr2:67841835 A/T cg00907274 chr3:27498161 SLC4A7 -0.48 -6.13 -0.32 2.55e-9 Endometriosis; CRC cis rs8177253 0.829 rs9813689 chr3:133514822 C/T cg01448562 chr3:133502909 NA -0.67 -11.46 -0.53 8e-26 Iron status biomarkers; CRC trans rs1979967 0.524 rs28687858 chr15:79661109 T/C cg14802097 chr12:42970349 PRICKLE1 0.49 6.04 0.32 4.2e-9 Interleukin-18 levels; CRC cis rs3823572 0.504 rs2971968 chr7:133642599 C/A cg03336402 chr7:133662267 EXOC4 -0.68 -10.48 -0.5 2.23e-22 Intelligence (multi-trait analysis); CRC trans rs2303319 0.504 rs58622044 chr2:162596287 A/G cg14875682 chr5:52083620 ITGA1;PELO -0.76 -6.4 -0.33 5.35e-10 Cognitive function; CRC cis rs28386778 0.897 rs894413 chr17:61916347 A/G cg22520471 chr17:61851767 DDX42;CCDC47 0.75 11.71 0.54 1.02e-26 Prudent dietary pattern; CRC cis rs17152411 0.843 rs7896051 chr10:126583119 T/C cg07906193 chr10:126599966 NA 0.54 6.0 0.31 5.1e-9 Height; CRC trans rs10982213 0.830 rs2274163 chr9:117188714 C/T cg25291941 chr8:99129319 POP1;HRSP12 0.43 6.69 0.35 9.65e-11 Interleukin-6 levels; CRC cis rs1707322 1.000 rs4390216 chr1:46266456 C/T cg06784218 chr1:46089804 CCDC17 0.5 8.71 0.43 1.55e-16 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs35883536 0.868 rs2484535 chr1:101107748 C/T cg14515779 chr1:101123966 NA 0.38 7.16 0.37 5.23e-12 Monocyte count; CRC cis rs908922 0.676 rs12129646 chr1:152518816 C/T cg23254163 chr1:152506842 NA 0.44 8.71 0.43 1.53e-16 Hair morphology; CRC cis rs9311474 0.607 rs4234633 chr3:52557038 C/T cg08222913 chr3:52553049 STAB1 -0.36 -6.78 -0.35 5.51e-11 Electroencephalogram traits; CRC cis rs1008375 0.797 rs6843530 chr4:17593605 G/T cg02297831 chr4:17616191 MED28 0.43 5.64 0.3 3.73e-8 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs12594515 0.967 rs11070465 chr15:45984899 A/G cg22117107 chr15:45993392 NA -0.45 -8.97 -0.44 2.28e-17 Waist circumference;Weight; CRC cis rs597539 0.616 rs473997 chr11:68639481 C/T cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.85 13.57 0.6 1.25e-33 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs9467711 0.659 rs35304979 chr6:26356347 C/A cg14345882 chr6:26364793 BTN3A2 0.64 5.63 0.3 3.85e-8 Autism spectrum disorder or schizophrenia; CRC trans rs60843830 1.000 rs2290911 chr2:224919 A/G cg11347411 chr7:150020925 ACTR3C;LRRC61 0.6 9.08 0.45 9.93e-18 Spherical equivalent (joint analysis main effects and education interaction); CRC cis rs4665809 0.556 rs4665322 chr2:26434605 C/G cg25036284 chr2:26402008 FAM59B -0.64 -8.48 -0.42 7.63e-16 Gut microbiome composition (summer); CRC cis rs10504229 0.724 rs72650827 chr8:58126884 A/T cg21724239 chr8:58056113 NA 0.49 6.81 0.35 4.75e-11 Developmental language disorder (linguistic errors); CRC cis rs7212938 0.570 rs8071050 chr17:38106599 A/G cg00129232 chr17:37814104 STARD3 0.37 5.7 0.3 2.73e-8 Asthma and hay fever; CRC cis rs2836974 0.568 rs414850 chr21:40543337 A/C cg11890956 chr21:40555474 PSMG1 0.93 16.8 0.68 3.52e-46 Cognitive function; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg27001607 chr7:76178636 LOC100133091 0.46 6.19 0.32 1.8e-9 Anxiety disorder; CRC cis rs66887589 0.777 rs4643791 chr4:120265619 A/G cg09307838 chr4:120376055 NA -0.56 -8.69 -0.43 1.72e-16 Diastolic blood pressure; CRC cis rs1865760 0.555 rs2051541 chr6:25945211 C/T cg03264133 chr6:25882463 NA 0.4 5.95 0.31 7.02e-9 Height; CRC cis rs7246657 0.943 rs4803347 chr19:37848017 G/A cg23950597 chr19:37808831 NA -0.46 -5.61 -0.3 4.3e-8 Coronary artery calcification; CRC cis rs6860806 0.695 rs6867282 chr5:131583120 G/C cg12564285 chr5:131593104 PDLIM4 0.49 9.51 0.46 4.16e-19 Breast cancer; CRC cis rs7666738 0.830 rs1876192 chr4:98727555 T/C cg05340658 chr4:99064831 C4orf37 0.54 8.0 0.4 2.21e-14 Colonoscopy-negative controls vs population controls; CRC trans rs10838798 0.504 rs11039634 chr11:48297843 A/G cg03929089 chr4:120376271 NA -0.46 -6.53 -0.34 2.55e-10 Height; CRC cis rs908922 0.676 rs4112786 chr1:152532872 T/A cg09873164 chr1:152488093 CRCT1 0.36 6.16 0.32 2.11e-9 Hair morphology; CRC cis rs57590327 0.527 rs9845467 chr3:81614473 G/A cg07356753 chr3:81810745 GBE1 -0.53 -7.06 -0.36 1.02e-11 Extraversion; CRC cis rs873946 0.557 rs34854637 chr10:134582962 A/G cg26818010 chr10:134567672 INPP5A -0.65 -8.42 -0.42 1.19e-15 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CRC trans rs6076960 0.652 rs3843045 chr20:6264593 C/T cg17788362 chr6:86352627 SYNCRIP -0.46 -6.49 -0.34 3.08e-10 Smooth-surface caries; CRC cis rs7086803 1.000 rs7096588 chr10:114500851 A/C cg03281572 chr10:114502318 VTI1A 0.75 6.34 0.33 7.77e-10 Lung cancer; CRC cis rs3820928 1.000 rs10210763 chr2:227776029 G/T cg11843606 chr2:227700838 RHBDD1 -0.41 -5.96 -0.31 6.39e-9 Pulmonary function; CRC cis rs8060686 0.858 rs2271294 chr16:67902326 A/T cg00318322 chr16:67708822 GFOD2 -0.31 -5.99 -0.31 5.54e-9 HDL cholesterol;Metabolic syndrome; CRC cis rs10504229 1.000 rs57261109 chr8:58172152 C/T cg02725872 chr8:58115012 NA -0.38 -6.43 -0.33 4.44e-10 Developmental language disorder (linguistic errors); CRC cis rs7274811 0.744 rs6120316 chr20:32177079 T/C cg07470512 chr20:32255052 NECAB3;C20orf134 -0.45 -5.91 -0.31 8.71e-9 Height; CRC trans rs2243480 1.000 rs1638734 chr7:66097539 A/C cg10756647 chr7:56101905 PSPH 0.75 7.82 0.4 7.35e-14 Diabetic kidney disease; CRC cis rs7267979 0.780 rs6050679 chr20:25537827 A/T cg24626310 chr20:25276739 ABHD12;PYGB 0.32 5.69 0.3 2.75e-8 Liver enzyme levels (alkaline phosphatase); CRC cis rs4713118 0.513 rs149897 chr6:28006650 A/G cg15845792 chr6:28175446 NA 0.75 11.11 0.52 1.51e-24 Parkinson's disease; CRC cis rs425277 0.500 rs908744 chr1:2038893 G/A cg04315214 chr1:2043799 PRKCZ 0.45 8.11 0.41 1.03e-14 Height; CRC cis rs72634258 0.945 rs7539255 chr1:8133352 T/C cg00042356 chr1:8021962 PARK7 0.73 7.64 0.39 2.36e-13 Inflammatory bowel disease; CRC cis rs2992756 0.663 rs2992762 chr1:18804609 A/G cg14356550 chr1:18808102 KLHDC7A -0.4 -5.87 -0.31 1.05e-8 Breast cancer; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg23435730 chr3:127770634 SEC61A1 0.45 6.15 0.32 2.28e-9 Thyroid stimulating hormone; CRC cis rs7246657 0.943 rs28373708 chr19:37976659 C/T cg23950597 chr19:37808831 NA -0.48 -5.82 -0.31 1.41e-8 Coronary artery calcification; CRC cis rs2404602 0.716 rs12441247 chr15:76812316 T/C cg23625390 chr15:77176239 SCAPER 0.51 7.39 0.38 1.24e-12 Blood metabolite levels; CRC cis rs4073582 0.595 rs9326370 chr11:65992008 A/G cg14036092 chr11:66035641 RAB1B 0.53 8.72 0.43 1.38e-16 Gout; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg18084450 chr1:235530719 TBCE 0.45 6.66 0.34 1.17e-10 Intelligence (multi-trait analysis); CRC cis rs2535633 0.631 rs9823697 chr3:53002150 A/G cg15147215 chr3:52552868 STAB1 -0.43 -6.88 -0.35 3.1e-11 Body mass index; CRC cis rs873946 0.618 rs12775767 chr10:134545628 C/T cg06453172 chr10:134556979 INPP5A -0.7 -8.39 -0.42 1.46e-15 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CRC cis rs7172809 0.897 rs78412727 chr15:77827185 A/G cg10437265 chr15:77819839 NA -0.4 -6.75 -0.35 6.52e-11 Glucose homeostasis traits; CRC trans rs10504229 0.815 rs75577263 chr8:58188434 A/G cg04077850 chr5:125800366 GRAMD3 0.37 6.27 0.33 1.15e-9 Developmental language disorder (linguistic errors); CRC cis rs10857712 0.703 rs12253520 chr10:135235321 C/A cg19904058 chr10:135279010 LOC619207 -0.35 -6.71 -0.35 8.35e-11 Systemic lupus erythematosus; CRC cis rs9549367 0.713 rs2476328 chr13:113829350 C/T cg18105134 chr13:113819100 PROZ 0.81 12.56 0.57 8.3e-30 Platelet distribution width; CRC cis rs3936840 0.539 rs3742441 chr14:102970581 C/G cg18135206 chr14:102964638 TECPR2 0.52 6.19 0.32 1.81e-9 Plateletcrit; CRC cis rs2658782 1.000 rs2658778 chr11:93148948 C/G cg15737290 chr11:93063684 CCDC67 0.51 7.47 0.38 7.46e-13 Pulmonary function decline; CRC cis rs10504229 0.728 rs17804774 chr8:58155950 G/T cg08219700 chr8:58056026 NA 0.45 5.66 0.3 3.37e-8 Developmental language disorder (linguistic errors); CRC cis rs9902453 0.933 rs1532042 chr17:28504389 G/T cg26525008 chr17:28256777 EFCAB5;SSH2 0.6 9.43 0.46 7.7e-19 Coffee consumption (cups per day); CRC cis rs8078723 0.738 rs3816472 chr17:38142677 A/C cg17344932 chr17:38183730 MED24;SNORD124 0.48 7.91 0.4 3.96e-14 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); CRC cis rs2842992 0.830 rs1475123 chr6:160178007 A/G cg19482086 chr6:160211437 TCP1;MRPL18 0.69 9.35 0.46 1.37e-18 Age-related macular degeneration (geographic atrophy); CRC trans rs9393777 0.844 rs35909544 chr6:27163456 G/A cg06606381 chr12:133084897 FBRSL1 -0.94 -7.11 -0.36 7.46e-12 Intelligence (multi-trait analysis); CRC cis rs4713118 0.869 rs9468214 chr6:27713299 G/C cg15786705 chr6:28176104 NA 0.57 7.98 0.4 2.53e-14 Parkinson's disease; CRC cis rs7998202 0.667 rs914017 chr13:113355037 G/A cg02820901 chr13:113351484 ATP11A 0.61 6.65 0.34 1.2e-10 Glycated hemoglobin levels; CRC cis rs6880778 0.505 rs12658567 chr5:40391932 G/T cg09067459 chr5:40385259 NA -0.47 -8.04 -0.41 1.68e-14 Inflammatory bowel disease; CRC cis rs4604732 0.631 rs12038793 chr1:247624262 C/T cg02104434 chr1:247694406 LOC148824;OR2C3 -0.54 -7.98 -0.4 2.39e-14 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CRC cis rs853679 0.769 rs7752448 chr6:28301099 A/G cg02683197 chr6:28174875 NA 0.67 6.03 0.32 4.47e-9 Depression; CRC cis rs1568889 0.877 rs17310076 chr11:28147590 C/T cg06544937 chr11:28130018 METT5D1;KIF18A 0.7 7.93 0.4 3.47e-14 Bipolar disorder; CRC cis rs1552244 0.572 rs2054478 chr3:10172211 C/T cg00166722 chr3:10149974 C3orf24 0.69 8.15 0.41 7.57e-15 Alzheimer's disease; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg04533189 chr17:64298763 PRKCA 0.37 6.91 0.36 2.46e-11 Liver disease severity in Alagille syndrome; CRC cis rs1552244 0.882 rs28366039 chr3:10028988 C/A cg18598329 chr3:10140678 FANCD2;C3orf24 -0.76 -9.12 -0.45 7.54e-18 Alzheimer's disease; CRC cis rs2115630 1.000 rs7183401 chr15:85371944 G/T cg09876464 chr15:85330779 ZNF592 0.46 8.19 0.41 5.93e-15 P wave terminal force; CRC cis rs12137294 0.866 rs1077883 chr1:205210415 G/T cg24159697 chr1:205181237 DSTYK -0.34 -6.25 -0.33 1.31e-9 Red cell distribution width; CRC cis rs11711311 1.000 rs10212375 chr3:113471336 G/A cg15478005 chr3:113465772 ATP6V1A;NAA50 0.42 5.82 0.31 1.4e-8 IgG glycosylation; CRC cis rs10782582 0.569 rs1770892 chr1:76389359 T/C cg03433033 chr1:76189801 ACADM -0.4 -5.8 -0.3 1.59e-8 Daytime sleep phenotypes; CRC cis rs4665809 1.000 rs6750681 chr2:26329677 C/T cg04944784 chr2:26401820 FAM59B -0.6 -7.66 -0.39 2.09e-13 Gut microbiome composition (summer); CRC cis rs1552244 0.554 rs59465469 chr3:9990800 G/C cg00166722 chr3:10149974 C3orf24 0.39 6.03 0.32 4.29e-9 Alzheimer's disease; CRC cis rs11098499 0.754 rs1546503 chr4:120241167 T/C cg24375607 chr4:120327624 NA 0.47 7.33 0.37 1.79e-12 Corneal astigmatism; CRC trans rs11654801 0.812 rs11655512 chr17:20851735 A/G cg23759823 chr7:139672531 TBXAS1 -0.43 -6.49 -0.34 3.13e-10 Mosquito bite size; CRC cis rs796364 0.951 rs6722092 chr2:201059371 G/T cg12253985 chr2:200820533 C2orf60;C2orf47 0.5 5.74 0.3 2.17e-8 Schizophrenia; CRC cis rs2739330 0.828 rs2186366 chr22:24254113 A/G cg16132339 chr22:24313637 DDTL;DDT -0.6 -9.77 -0.47 5.63e-20 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs7258465 1.000 rs10164319 chr19:18569833 G/A cg10790698 chr19:18539756 SSBP4 -0.43 -8.19 -0.41 5.83e-15 Breast cancer; CRC cis rs11971779 0.648 rs28754644 chr7:139065057 C/T cg23387468 chr7:139079360 LUC7L2 0.41 7.04 0.36 1.14e-11 Diisocyanate-induced asthma; CRC cis rs6570726 0.791 rs4335004 chr6:145904764 G/A cg05347473 chr6:146136440 FBXO30 0.4 6.05 0.32 3.89e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs2739330 0.828 rs2186366 chr22:24254113 A/G cg04234412 chr22:24373322 LOC391322 0.71 11.64 0.54 1.82e-26 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs4660306 0.884 rs7543076 chr1:45964238 T/C cg03123370 chr1:45965343 CCDC163P;MMACHC -0.56 -7.85 -0.4 5.99e-14 Homocysteine levels; CRC cis rs13118159 0.778 rs12650998 chr4:1338832 T/C cg02018176 chr4:1364513 KIAA1530 0.4 6.74 0.35 6.93e-11 Longevity; CRC cis rs524281 0.773 rs11227447 chr11:66048280 G/C cg16950941 chr11:66035639 RAB1B -0.72 -8.12 -0.41 9.39e-15 Electroencephalogram traits; CRC cis rs9826463 0.702 rs73228762 chr3:142325220 A/C cg20824294 chr3:142316082 PLS1 0.44 6.1 0.32 2.99e-9 QRS duration in Tripanosoma cruzi seropositivity; CRC cis rs9858542 0.953 rs6997 chr3:49453834 C/T cg00383909 chr3:49044727 WDR6 0.44 5.73 0.3 2.24e-8 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs2050392 0.517 rs302423 chr10:30772513 A/G cg18806716 chr10:30721971 MAP3K8 -0.58 -8.08 -0.41 1.27e-14 Inflammatory bowel disease; CRC cis rs853679 0.517 rs6922063 chr6:28094366 G/A cg15786705 chr6:28176104 NA 0.74 9.41 0.46 8.75e-19 Depression; CRC cis rs881375 0.933 rs7028641 chr9:123691141 G/C cg14255062 chr9:123606675 PSMD5;LOC253039 0.41 5.93 0.31 7.74e-9 Rheumatoid arthritis; CRC cis rs2012796 0.785 rs61986597 chr14:81853107 T/C cg02996355 chr14:81879375 NA 0.62 9.49 0.46 4.71e-19 Night sleep phenotypes; CRC cis rs2120019 0.935 rs8043181 chr15:75380424 T/C cg11632617 chr15:75315747 PPCDC -0.56 -7.95 -0.4 3.01e-14 Blood trace element (Zn levels); CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg21123913 chr4:89513664 HERC3 -0.41 -6.29 -0.33 1.02e-9 Myopia (pathological); CRC cis rs1005277 0.579 rs1614236 chr10:38502996 C/T cg17219203 chr10:38645113 HSD17B7P2 -0.41 -5.69 -0.3 2.75e-8 Extrinsic epigenetic age acceleration; CRC cis rs3858526 0.959 rs10838797 chr11:5920977 A/G cg26762873 chr11:5879799 OR52E8 -0.41 -6.01 -0.31 4.87e-9 DNA methylation (variation); CRC cis rs1348850 0.632 rs13009207 chr2:178501632 A/G cg22681709 chr2:178499509 PDE11A -0.48 -8.82 -0.44 6.72e-17 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs2836974 0.932 rs35571600 chr21:40590624 A/C cg06238570 chr21:40685208 BRWD1 0.76 10.52 0.5 1.66e-22 Cognitive function; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg25093320 chr17:80023187 DUS1L 0.49 6.38 0.33 5.96e-10 Anxiety disorder; CRC cis rs2932538 0.744 rs6537742 chr1:113085197 G/T cg22162597 chr1:113214053 CAPZA1 0.67 8.18 0.41 6.34e-15 Systolic blood pressure;Diastolic blood pressure;Hypertension;Blood pressure; CRC cis rs9420 0.961 rs80304923 chr11:57522823 C/G cg23127183 chr11:57508653 C11orf31 -0.53 -7.08 -0.36 8.9e-12 Schizophrenia; CRC cis rs4073416 0.542 rs10144979 chr14:65997638 G/A cg03016385 chr14:66212404 NA -0.42 -5.93 -0.31 7.71e-9 N-glycan levels; CRC cis rs875971 0.862 rs4718383 chr7:66108409 T/C cg00343986 chr7:65444356 GUSB -0.46 -6.39 -0.33 5.69e-10 Aortic root size; CRC cis rs897984 0.762 rs7204459 chr16:30984212 G/A cg02466173 chr16:30829666 NA 0.61 9.0 0.44 1.87e-17 Dementia with Lewy bodies; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg04661747 chr11:46264818 NA 0.44 6.29 0.33 1.01e-9 Response to antipsychotic treatment; CRC cis rs2075371 0.966 rs722657 chr7:133994956 T/C cg02659138 chr7:134003124 SLC35B4 0.42 7.35 0.38 1.57e-12 Mean platelet volume; CRC cis rs10503871 0.657 rs6997017 chr8:30341945 A/G cg26383811 chr8:30366931 RBPMS 0.5 7.95 0.4 3.11e-14 Metabolite levels (X-11787); CRC cis rs10256972 0.577 rs6962809 chr7:1208889 A/G cg27094323 chr7:1216898 NA -0.41 -6.78 -0.35 5.68e-11 Longevity;Endometriosis; CRC cis rs780094 0.544 rs2303370 chr2:27651375 C/T cg21248554 chr2:27665150 KRTCAP3 -0.29 -6.69 -0.35 9.65e-11 Calcium levels;Fasting blood insulin;Metabolic traits;Triglyceride levels;Fasting plasma glucose;Urate levels in overweight individuals;Urate levels in obese individuals;Uric acid levels;Height;Age-related diseases, mortality and associated endophenotypes;Renal underexcretion gout;Fasting blood glucose (BMI interaction);Urate levels;Gondoic acid (20:1n-9) levels;Fasting blood insulin (BMI interaction);Triglycerides;Plasma omega-3 polyunsaturated fatty acid levels (docosapentaenoic acid);Type 2 diabetes;Nonalcoholic fatty liver disease;Hypertriglyceridemia;C-reactive protein;Age-related disease endophenotypes;LDL cholesterol;Metabolic syndrome;Crohn's disease;Alcohol consumption (drinks per week);Homeostasis model assessment of insulin resistance;Alcohol consumption;Red blood cell count;Fasting blood glucose; CRC cis rs3849570 0.643 rs10779986 chr3:81970818 C/G cg07356753 chr3:81810745 GBE1 0.56 7.68 0.39 1.85e-13 Waist circumference;Body mass index; CRC cis rs736408 0.545 rs6445529 chr3:52662722 T/A cg15147215 chr3:52552868 STAB1 -0.64 -11.08 -0.52 1.91e-24 Bipolar disorder; CRC cis rs9916302 0.706 rs4794808 chr17:37531916 C/T cg07936489 chr17:37558343 FBXL20 0.92 11.73 0.54 9.09e-27 Glomerular filtration rate (creatinine); CRC cis rs1865760 0.892 rs6456705 chr6:25936056 G/A cg17691542 chr6:26056736 HIST1H1C 0.54 7.69 0.39 1.74e-13 Height; CRC cis rs9372498 0.536 rs9489452 chr6:118910868 G/C cg10217327 chr6:118973057 C6orf204 0.52 5.91 0.31 8.63e-9 Diastolic blood pressure; CRC cis rs13161895 0.818 rs78282770 chr5:179483686 T/A cg02702477 chr5:179499311 RNF130 0.69 7.6 0.39 3.1400000000000003e-13 LDL cholesterol; CRC cis rs4332037 0.624 rs56256289 chr7:1892529 C/T cg25834613 chr7:1915315 MAD1L1 -0.4 -6.16 -0.32 2.07e-9 Bipolar disorder; CRC cis rs6502050 0.835 rs8065037 chr17:80158966 T/G cg13198984 chr17:80129470 CCDC57 0.42 7.33 0.37 1.77e-12 Life satisfaction; CRC cis rs561341 1.000 rs548957 chr17:30302411 G/A cg12193833 chr17:30244370 NA -0.75 -8.8 -0.44 7.92e-17 Hip circumference adjusted for BMI; CRC cis rs6952808 0.723 rs4721287 chr7:2028663 A/C cg21782813 chr7:2030301 MAD1L1 0.54 9.44 0.46 7.29e-19 Bipolar disorder and schizophrenia; CRC cis rs11577318 0.853 rs4450008 chr1:26643860 C/A cg04990556 chr1:26633338 UBXN11 -0.47 -5.92 -0.31 7.95e-9 Granulocyte percentage of myeloid white cells; CRC cis rs1552244 1.000 rs111392584 chr3:10075991 A/G cg00166722 chr3:10149974 C3orf24 0.71 9.49 0.46 4.86e-19 Alzheimer's disease; CRC cis rs11148252 0.740 rs3803264 chr13:52971893 A/G cg00495681 chr13:53174319 NA -0.54 -7.82 -0.4 7.3e-14 Lewy body disease; CRC cis rs1152591 1.000 rs1152591 chr14:64680848 A/G cg23250157 chr14:64679961 SYNE2 0.5 7.62 0.39 2.66e-13 Atrial fibrillation; CRC cis rs4481887 0.893 rs6681339 chr1:248482761 C/G cg13385794 chr1:248469461 NA 0.4 7.11 0.36 7.23e-12 Common traits (Other); CRC cis rs12681287 0.570 rs4961188 chr8:87383033 T/C cg27223183 chr8:87520930 FAM82B 0.53 7.24 0.37 3.25e-12 Caudate activity during reward; CRC cis rs4664304 0.966 rs1397707 chr2:160760972 C/T cg03641300 chr2:160917029 PLA2R1 -0.42 -5.89 -0.31 9.71e-9 Crohn's disease;Inflammatory bowel disease; CRC trans rs67073037 0.955 rs67612857 chr2:29161707 G/C cg13899017 chr1:159158444 CADM3 -0.37 -6.14 -0.32 2.4e-9 Breast cancer;Breast cancer (estrogen-receptor negative); CRC cis rs8180040 0.764 rs4682852 chr3:47177772 C/T cg27129171 chr3:47204927 SETD2 0.76 13.1 0.59 7.48e-32 Colorectal cancer; CRC cis rs67340775 0.541 rs200964 chr6:27866943 G/C cg02683197 chr6:28174875 NA 0.72 7.18 0.37 4.65e-12 Lung cancer in ever smokers; CRC cis rs7107174 1.000 rs2510043 chr11:77977481 C/G cg02023728 chr11:77925099 USP35 0.48 8.3 0.42 2.74e-15 Testicular germ cell tumor; CRC cis rs2749592 0.550 rs4934881 chr10:37914346 A/C cg00409905 chr10:38381863 ZNF37A 0.59 9.36 0.46 1.33e-18 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs28735056 0.933 rs499260 chr18:77589689 G/A cg20368463 chr18:77673604 PQLC1 -0.54 -8.44 -0.42 9.91e-16 Schizophrenia; CRC cis rs12887734 0.524 rs12888002 chr14:104238647 T/C cg01849466 chr14:104193079 ZFYVE21 -0.42 -6.4 -0.33 5.2400000000000005e-10 Schizophrenia;Autism spectrum disorder or schizophrenia; CRC trans rs2303319 0.504 rs2175142 chr2:162450124 T/C cg10272801 chr16:14013773 ERCC4 -0.68 -6.01 -0.31 4.9e-9 Cognitive function; CRC cis rs1707322 0.721 rs10890344 chr1:46166090 C/T cg06784218 chr1:46089804 CCDC17 0.66 12.38 0.56 3.81e-29 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs1023500 0.552 rs133368 chr22:42463689 T/C cg04733989 chr22:42467013 NAGA 0.59 9.07 0.45 1.09e-17 Schizophrenia; CRC cis rs10504229 1.000 rs59071610 chr8:58186301 A/C cg22535103 chr8:58192502 C8orf71 -0.81 -12.15 -0.56 2.51e-28 Developmental language disorder (linguistic errors); CRC cis rs7119 0.679 rs12909808 chr15:77816944 A/G cg10437265 chr15:77819839 NA 0.69 12.74 0.57 1.76e-30 Type 2 diabetes; CRC cis rs875971 1.000 rs2420591 chr7:65912381 T/C cg00343986 chr7:65444356 GUSB 0.43 6.29 0.33 1.03e-9 Aortic root size; CRC cis rs6499255 0.903 rs1800566 chr16:69745145 C/T cg15192750 chr16:69999425 NA 0.61 8.17 0.41 6.81e-15 IgE levels; CRC cis rs7705042 0.897 rs249681 chr5:141538017 G/C cg08523384 chr5:141488047 NDFIP1 -0.32 -5.71 -0.3 2.55e-8 Asthma; CRC trans rs10983614 1.000 rs7867776 chr9:120072627 A/G cg13479780 chr6:41909532 CCND3 0.44 6.13 0.32 2.57e-9 Survival in pancreatic cancer; CRC cis rs4909189 0.915 rs11773551 chr7:158136146 C/T cg23298862 chr7:158159286 PTPRN2 0.49 7.03 0.36 1.17e-11 Response to amphetamines; CRC cis rs4718428 0.672 rs13241598 chr7:66300652 A/G cg18252515 chr7:66147081 NA -0.54 -7.49 -0.38 6.26e-13 Corneal structure; CRC cis rs501120 0.584 rs7086639 chr10:44698695 C/T cg09554077 chr10:44749378 NA 0.69 7.91 0.4 4.04e-14 Coronary artery disease;Coronary heart disease; CRC cis rs589448 0.902 rs315134 chr12:69762713 G/A cg14784868 chr12:69753453 YEATS4 0.91 17.67 0.7 1.31e-49 Cerebrospinal fluid biomarker levels; CRC cis rs13082711 0.911 rs2172298 chr3:27425611 T/C cg02860705 chr3:27208620 NA 0.59 8.61 0.43 3.16e-16 Systolic blood pressure;Diastolic blood pressure;Blood pressure; CRC cis rs10504229 0.728 rs55812114 chr8:58157453 C/T cg05313129 chr8:58192883 C8orf71 -0.48 -6.25 -0.33 1.29e-9 Developmental language disorder (linguistic errors); CRC cis rs9322193 0.923 rs9688861 chr6:149959060 G/T cg05861140 chr6:150128134 PCMT1 -0.36 -5.92 -0.31 8.15e-9 Lung cancer; CRC cis rs6456156 0.792 rs4710178 chr6:167513532 G/A cg07513332 chr6:167530253 CCR6 0.37 6.18 0.32 1.89e-9 Primary biliary cholangitis; CRC cis rs7829975 0.688 rs13270194 chr8:8378102 T/C cg06636001 chr8:8085503 FLJ10661 0.55 8.4 0.42 1.38e-15 Mood instability; CRC cis rs12908161 0.959 rs2175567 chr15:85200946 C/G cg17507749 chr15:85114479 UBE2QP1 0.62 8.8 0.44 7.9e-17 Schizophrenia; CRC cis rs58688157 0.739 rs56333810 chr11:575408 C/G cg16486109 chr11:613632 IRF7 0.64 11.34 0.53 2.3e-25 Systemic lupus erythematosus; CRC cis rs6921919 0.789 rs13210258 chr6:28308671 G/T cg21251018 chr6:28226885 NKAPL 0.43 6.47 0.34 3.53e-10 Autism spectrum disorder or schizophrenia; CRC cis rs13315871 1.000 rs28489489 chr3:58443755 C/A cg20936604 chr3:58311152 NA -0.72 -7.15 -0.37 5.58e-12 Cholesterol, total; CRC cis rs17376456 0.825 rs13156202 chr5:93157721 C/T cg25358565 chr5:93447407 FAM172A -0.95 -10.01 -0.48 8.8e-21 Diabetic retinopathy; CRC cis rs16975963 0.793 rs12460735 chr19:38313550 C/T cg15135657 chr19:38346511 NA -0.44 -5.92 -0.31 8.15e-9 Longevity; CRC cis rs11148252 0.532 rs9536185 chr13:53179801 G/A cg00495681 chr13:53174319 NA 1.06 21.5 0.76 1.2e-64 Lewy body disease; CRC cis rs6951245 0.745 rs79788515 chr7:1101079 C/T cg20603222 chr7:1096387 C7orf50;GPR146 -0.72 -8.53 -0.43 5.31e-16 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs4975616 0.869 rs380286 chr5:1320247 G/A cg26373071 chr5:1325741 CLPTM1L 0.54 9.71 0.47 8.88e-20 Lung cancer; CRC cis rs889312 0.500 rs1867731 chr5:56132115 C/G cg12311346 chr5:56204834 C5orf35 -0.45 -6.83 -0.35 4.12e-11 Breast cancer;Breast cancer (early onset); CRC trans rs3733585 0.673 rs4459990 chr4:9954005 T/C cg26043149 chr18:55253948 FECH -0.5 -7.71 -0.39 1.51e-13 Cleft plate (environmental tobacco smoke interaction); CRC trans rs7395662 1.000 rs6485872 chr11:48579710 A/C cg21153622 chr11:89784906 NA -0.48 -7.68 -0.39 1.82e-13 HDL cholesterol; CRC cis rs2223471 0.719 rs9381901 chr6:50765751 A/G cg03432817 chr6:50765336 NA 0.35 5.64 0.3 3.61e-8 Subcutaneous adipose tissue; CRC cis rs2692947 0.567 rs4907276 chr2:96391109 G/T cg23100626 chr2:96804247 ASTL -0.26 -6.61 -0.34 1.51e-10 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; CRC cis rs9443645 0.901 rs2152951 chr6:79762172 A/G cg05283184 chr6:79620031 NA 0.57 9.08 0.45 1.05e-17 Intelligence (multi-trait analysis); CRC cis rs2952156 1.000 rs2643195 chr17:37853118 A/G cg20243544 chr17:37824526 PNMT 0.54 8.26 0.41 3.71e-15 Asthma; CRC cis rs453193 0.714 rs2562008 chr2:8447640 A/G cg12167548 chr2:8464763 NA 0.29 5.75 0.3 2.02e-8 Granulocyte percentage of myeloid white cells; CRC cis rs1320333 0.772 rs2867136 chr2:701455 T/C cg00500140 chr2:691012 NA -0.55 -6.7 -0.35 9.06e-11 Obesity-related traits; CRC cis rs9814567 1.000 rs11927068 chr3:134266321 A/G cg06541857 chr3:134203789 ANAPC13;CEP63 0.39 5.74 0.3 2.15e-8 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs7527798 0.592 rs6671969 chr1:207839667 C/T cg09232269 chr1:207846808 CR1L -0.52 -8.51 -0.42 6.22e-16 Erythrocyte sedimentation rate; CRC cis rs1881797 0.932 rs4551631 chr1:247667663 C/T cg18198730 chr1:247681584 NA -0.59 -10.03 -0.48 7.66e-21 Acute lymphoblastic leukemia (childhood); CRC cis rs7615952 0.599 rs1044215 chr3:125725559 C/G cg06494592 chr3:125709126 NA -0.52 -6.86 -0.35 3.36e-11 Blood pressure (smoking interaction); CRC cis rs8180040 0.966 rs11130137 chr3:47578838 C/T cg27129171 chr3:47204927 SETD2 0.52 7.88 0.4 4.86e-14 Colorectal cancer; CRC cis rs757110 0.933 rs7124355 chr11:17412960 C/T cg15432903 chr11:17409602 KCNJ11 -0.65 -9.56 -0.47 2.86e-19 Type 2 diabetes; CRC cis rs734999 0.545 rs6684865 chr1:2546229 A/G cg20673091 chr1:2541236 MMEL1 -0.35 -5.74 -0.3 2.19e-8 Ulcerative colitis; CRC cis rs9487051 0.802 rs6910696 chr6:109592329 A/T cg01475377 chr6:109611718 NA -0.47 -8.94 -0.44 2.86e-17 Reticulocyte fraction of red cells; CRC cis rs28386778 0.897 rs2236736 chr17:61938248 G/T cg06601766 chr17:61851465 DDX42;CCDC47 0.42 5.79 0.3 1.63e-8 Prudent dietary pattern; CRC cis rs6691722 0.503 rs6692646 chr1:24707629 C/T cg02336364 chr1:24764700 NIPAL3 0.37 6.13 0.32 2.53e-9 Response to interferon beta in multiple sclerosis; CRC trans rs7705042 0.861 rs6860138 chr5:141509985 G/A cg03701575 chr16:83960119 NA 0.34 5.97 0.31 6.14e-9 Asthma; CRC cis rs6088580 0.634 rs6059829 chr20:33017074 G/A cg08999081 chr20:33150536 PIGU 0.61 11.58 0.54 3.15e-26 Glomerular filtration rate (creatinine); CRC cis rs10771431 1.000 rs10771431 chr12:9380859 C/T cg22349387 chr12:9600060 DDX12 -0.36 -5.71 -0.3 2.53e-8 Breast size; CRC cis rs7618915 0.571 rs33964154 chr3:52596914 A/G cg11645453 chr3:52864694 ITIH4 0.34 5.92 0.31 8.26e-9 Bipolar disorder; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg27098574 chr16:75285489 BCAR1 0.44 7.09 0.36 8.04e-12 Liver disease severity in Alagille syndrome; CRC cis rs4757319 0.515 rs7125389 chr11:15438571 A/G cg03245590 chr11:15329459 NA 0.52 9.0 0.44 1.88e-17 Breast cancer; CRC cis rs317689 0.819 rs317683 chr12:69713630 T/G cg20891283 chr12:69753455 YEATS4 0.46 5.98 0.31 5.68e-9 Response to diuretic therapy; CRC cis rs7107174 0.892 rs1007837 chr11:77941076 A/G cg02023728 chr11:77925099 USP35 0.5 8.49 0.42 7.39e-16 Testicular germ cell tumor; CRC cis rs6062302 0.522 rs914558 chr20:62216976 A/G cg06363034 chr20:62225388 GMEB2 -0.41 -6.34 -0.33 7.76e-10 Glioblastoma; CRC cis rs7772486 0.875 rs9403764 chr6:146360582 G/A cg05347473 chr6:146136440 FBXO30 0.36 5.65 0.3 3.5e-8 Lobe attachment (rater-scored or self-reported); CRC trans rs35110281 0.693 rs4819290 chr21:45122713 C/T cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.44 7.13 0.37 6.51e-12 Mean corpuscular volume; CRC trans rs6951245 1.000 rs11763835 chr7:1094513 A/G cg13565492 chr6:43139072 SRF -0.72 -7.44 -0.38 8.66e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs7131987 0.718 rs7976961 chr12:29463088 C/T cg09582351 chr12:29534625 ERGIC2 -0.33 -7.04 -0.36 1.1e-11 QT interval; CRC cis rs7772486 0.790 rs7753696 chr6:146279098 G/T cg13319975 chr6:146136371 FBXO30 0.43 6.46 0.34 3.66e-10 Lobe attachment (rater-scored or self-reported); CRC cis rs4713118 0.516 rs4713142 chr6:28106347 T/G cg06470822 chr6:28175283 NA 1.0 13.33 0.59 1.06e-32 Parkinson's disease; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg16841327 chr22:46466183 NA 0.38 6.53 0.34 2.48e-10 Liver disease severity in Alagille syndrome; CRC cis rs1046896 0.552 rs12602280 chr17:80805421 G/C cg16060761 chr17:80687452 NA -0.48 -6.13 -0.32 2.55e-9 Glycated hemoglobin levels; CRC cis rs4728302 0.838 rs10225605 chr7:133591676 G/A cg10665199 chr7:133106180 EXOC4 0.39 5.84 0.31 1.25e-8 Intelligence;Intelligence (multi-trait analysis); CRC cis rs9914544 1.000 rs9916245 chr17:18766825 C/G cg26378065 chr17:18585709 ZNF286B 0.43 5.87 0.31 1.04e-8 Educational attainment (years of education); CRC trans rs1455244 0.700 rs7229302 chr18:11508904 G/T cg20087303 chr14:70233840 SFRS5;LOC100289511 0.38 6.15 0.32 2.22e-9 Schizophrenia; CRC cis rs4665809 0.549 rs3828255 chr2:26413252 G/A cg04944784 chr2:26401820 FAM59B 0.89 10.5 0.5 1.9e-22 Gut microbiome composition (summer); CRC cis rs28386778 0.966 rs2854206 chr17:61947203 G/A cg22520471 chr17:61851767 DDX42;CCDC47 0.72 11.18 0.52 7.95e-25 Prudent dietary pattern; CRC cis rs13108904 0.935 rs11247984 chr4:1292811 G/A cg16405210 chr4:1374714 KIAA1530 -0.44 -5.94 -0.31 7.1e-9 Obesity-related traits; CRC cis rs2952156 0.959 rs907087 chr17:37828787 G/A cg00129232 chr17:37814104 STARD3 -0.68 -11.08 -0.52 1.92e-24 Asthma; CRC cis rs9463078 0.764 rs10948194 chr6:44951990 A/C cg25276700 chr6:44698697 NA -0.28 -6.9 -0.36 2.61e-11 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; CRC cis rs9486715 0.867 rs4839834 chr6:96882109 C/A cg06623918 chr6:96969491 KIAA0776 1.01 20.09 0.74 3.94e-59 Headache; CRC cis rs898097 0.812 rs7406011 chr17:80829980 C/T cg19046167 chr17:80928561 B3GNTL1 -0.43 -6.65 -0.34 1.24e-10 Breast cancer; CRC cis rs9787249 0.915 rs6664570 chr1:40206298 G/A cg19912559 chr1:40204330 PPIE 0.52 7.66 0.39 2.05e-13 Blood protein levels; CRC cis rs3008870 0.959 rs2985826 chr1:67412918 G/C cg08660285 chr1:67390436 MIER1;WDR78 1.02 15.1 0.64 1.64e-39 Lymphocyte percentage of white cells; CRC cis rs4969178 0.965 rs12450500 chr17:76395750 C/T cg05887092 chr17:76393375 PGS1 0.55 10.0 0.48 1.01e-20 HDL cholesterol levels; CRC cis rs7223966 1.000 rs61360320 chr17:61800392 C/T cg05941027 chr17:61774174 LIMD2 0.36 6.4 0.33 5.23e-10 Hip circumference adjusted for BMI;Body mass index; CRC cis rs1348850 0.567 rs880897 chr2:178532503 C/T cg02961200 chr2:178257176 LOC100130691;AGPS 0.51 7.07 0.36 9.06e-12 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs6866344 0.697 rs62392823 chr5:178126968 T/C cg03877680 chr5:178157825 ZNF354A 0.77 10.96 0.52 4.9299999999999996e-24 Neutrophil percentage of white cells; CRC trans rs925098 0.577 rs2724470 chr4:17996046 A/G cg01947301 chr1:205718900 NUCKS1 -0.41 -6.06 -0.32 3.79e-9 Birth weight;Height; CRC cis rs10504229 0.517 rs75486476 chr8:58056079 G/T cg21724239 chr8:58056113 NA 0.87 18.17 0.71 1.34e-51 Developmental language disorder (linguistic errors); CRC cis rs1862618 0.671 rs2255726 chr5:56243128 T/C cg20203395 chr5:56204925 C5orf35 0.57 7.85 0.4 5.99e-14 Initial pursuit acceleration; CRC cis rs3815700 1.000 rs8100168 chr19:33093084 G/A cg02997394 chr19:33096574 ANKRD27 0.67 6.57 0.34 2.01e-10 Eosinophilic esophagitis; CRC cis rs5750830 0.649 rs5757663 chr22:39821319 T/C cg11247378 chr22:39784982 NA -0.41 -7.38 -0.38 1.31e-12 Intelligence (multi-trait analysis); CRC cis rs8180040 0.764 rs2132173 chr3:47247060 C/T cg10298567 chr3:47292165 KIF9 0.35 5.68 0.3 2.94e-8 Colorectal cancer; CRC cis rs919433 0.783 rs2565155 chr2:198236425 A/G cg03934865 chr2:198174659 NA 0.36 5.82 0.31 1.42e-8 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC cis rs17767294 0.612 rs9461424 chr6:27919401 G/A cg15786705 chr6:28176104 NA 0.57 5.78 0.3 1.73e-8 Parkinson's disease; CRC cis rs1129187 0.755 rs3293 chr6:42938377 G/T cg03790207 chr6:42947109 PEX6 -0.53 -7.75 -0.39 1.17e-13 Alzheimer's disease in APOE e4+ carriers; CRC cis rs875971 1.000 rs1182882 chr7:65562063 C/T cg18876405 chr7:65276391 NA -0.53 -9.14 -0.45 6.65e-18 Aortic root size; CRC cis rs10504229 0.679 rs72649109 chr8:58031274 A/T cg24829409 chr8:58192753 C8orf71 -0.59 -7.36 -0.38 1.48e-12 Developmental language disorder (linguistic errors); CRC cis rs4713118 0.824 rs9468225 chr6:27745719 T/G cg15845792 chr6:28175446 NA 0.68 8.8 0.44 8.02e-17 Parkinson's disease; CRC cis rs7666738 0.830 rs28728124 chr4:99001116 G/T cg17366294 chr4:99064904 C4orf37 0.43 7.36 0.38 1.53e-12 Colonoscopy-negative controls vs population controls; CRC cis rs4938330 0.608 rs12418744 chr11:117084537 G/A cg01368799 chr11:117014884 PAFAH1B2 -0.47 -5.98 -0.31 5.71e-9 Blood protein levels; CRC cis rs7705042 0.828 rs6877864 chr5:141503839 A/G cg07392085 chr5:141489673 NDFIP1 0.46 7.24 0.37 3.13e-12 Asthma; CRC cis rs7249142 0.527 rs12975096 chr19:19279409 G/T cg26504305 chr19:19281019 LOC729991-MEF2B;MEF2B -0.44 -8.79 -0.44 8.47e-17 IgG glycosylation; CRC cis rs11785400 0.793 rs750530 chr8:143744931 G/A cg10596483 chr8:143751796 JRK 0.43 5.78 0.3 1.75e-8 Schizophrenia; CRC cis rs3849570 0.533 rs6548784 chr3:81995889 G/A cg07356753 chr3:81810745 GBE1 -0.46 -6.26 -0.33 1.19e-9 Waist circumference;Body mass index; CRC cis rs10256972 0.552 rs2960830 chr7:1200641 T/C cg04025307 chr7:1156635 C7orf50 0.62 9.74 0.47 7.5e-20 Longevity;Endometriosis; CRC cis rs763121 0.819 rs8137829 chr22:39061030 G/A cg06022373 chr22:39101656 GTPBP1 0.79 12.53 0.57 1.01e-29 Menopause (age at onset); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg05147328 chr17:79849438 ANAPC11;THOC4 0.49 6.99 0.36 1.57e-11 Response to antipsychotic treatment; CRC cis rs55871839 0.708 rs4738732 chr8:59809943 A/G cg07426533 chr8:59803705 TOX 0.32 5.74 0.3 2.16e-8 Pneumonia; CRC cis rs7927771 1.000 rs2290850 chr11:47807774 T/C cg18512352 chr11:47633146 NA -0.49 -9.48 -0.46 5.08e-19 Subjective well-being; CRC cis rs1005277 0.579 rs2008449 chr10:38414204 A/T cg25427524 chr10:38739819 LOC399744 0.77 14.08 0.61 1.42e-35 Extrinsic epigenetic age acceleration; CRC cis rs853679 0.550 rs34477097 chr6:28197186 C/T cg15845792 chr6:28175446 NA 0.85 11.63 0.54 2.09e-26 Depression; CRC cis rs7918232 0.596 rs7902540 chr10:27304693 C/T cg14442939 chr10:27389572 ANKRD26 0.55 7.09 0.36 8.29e-12 Breast cancer; CRC cis rs853679 0.517 rs35512245 chr6:28079953 T/C cg12172441 chr6:28176163 NA 0.62 7.28 0.37 2.53e-12 Depression; CRC cis rs7113874 0.589 rs2028882 chr11:8504854 A/C cg17679104 chr11:8615758 STK33 -0.36 -5.89 -0.31 9.31e-9 Body mass index in physically active individuals;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs9372498 0.536 rs72969531 chr6:118729974 C/A cg10217327 chr6:118973057 C6orf204 0.5 5.69 0.3 2.82e-8 Diastolic blood pressure; CRC cis rs1046896 1.000 rs1046896 chr17:80685533 A/G cg19046167 chr17:80928561 B3GNTL1 -0.41 -6.5 -0.34 3.02e-10 Glycated hemoglobin levels; CRC cis rs870825 0.929 rs871254 chr4:185589226 G/C cg04058563 chr4:185651563 MLF1IP 0.64 6.6 0.34 1.6e-10 Blood protein levels; CRC cis rs8180040 0.966 rs9683177 chr3:47490493 G/A cg10298567 chr3:47292165 KIF9 -0.36 -5.86 -0.31 1.13e-8 Colorectal cancer; CRC cis rs9549328 0.756 rs2993291 chr13:113653846 C/T cg20742385 chr13:113633654 MCF2L -0.6 -8.97 -0.44 2.28e-17 Systolic blood pressure; CRC cis rs995000 0.868 rs6682423 chr1:63171063 C/T cg19896129 chr1:63156450 NA -0.44 -6.79 -0.35 5.09e-11 Triglyceride levels; CRC cis rs2070488 0.965 rs6599209 chr3:38558197 A/G cg01465620 chr3:38496096 LOC100128640;ACVR2B -0.87 -16.16 -0.67 1.19e-43 Electrocardiographic conduction measures; CRC cis rs9894429 0.646 rs9902264 chr17:79613828 G/A cg18240062 chr17:79603768 NPLOC4 0.47 7.45 0.38 8.45e-13 Eye color traits; CRC cis rs3767633 0.748 rs6667896 chr1:161837407 G/A cg09175582 chr1:161736000 ATF6 0.7 6.29 0.33 1.03e-9 IgG glycosylation; CRC cis rs4660214 0.614 rs11205802 chr1:39699114 C/T cg11070191 chr1:39582205 MACF1 0.36 5.81 0.3 1.49e-8 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs7937682 0.632 rs7112886 chr11:111743232 T/C cg19812747 chr11:111475976 SIK2 0.43 6.17 0.32 1.97e-9 Primary sclerosing cholangitis; CRC cis rs2032447 0.714 rs199725 chr6:25953684 A/G cg26028573 chr6:26043587 HIST1H2BB 0.44 6.46 0.34 3.84e-10 Intelligence (multi-trait analysis); CRC cis rs9926296 0.509 rs2159113 chr16:89832083 C/T cg02609749 chr16:89786786 C16orf7;ZNF276 0.43 6.15 0.32 2.3e-9 Vitiligo; CRC cis rs514406 0.929 rs1672909 chr1:53340824 A/G cg25767906 chr1:53392781 SCP2 -0.45 -7.38 -0.38 1.29e-12 Monocyte count; CRC cis rs10883723 0.773 rs2296587 chr10:104245588 G/A cg11453585 chr10:104263688 ACTR1A;SUFU 0.89 14.26 0.62 2.94e-36 Allergic disease (asthma, hay fever or eczema); CRC cis rs2576037 0.623 rs2576042 chr18:44577461 T/C cg23996704 chr18:44553084 KATNAL2 0.38 7.52 0.38 5.38e-13 Personality dimensions; CRC cis rs10883723 0.775 rs2296579 chr10:104241375 A/G cg04362960 chr10:104952993 NT5C2 -0.41 -5.62 -0.3 4.05e-8 Allergic disease (asthma, hay fever or eczema); CRC trans rs10507419 1.000 rs10507419 chr13:35186452 A/T cg00944431 chr1:10896004 NA -0.41 -6.0 -0.31 5.08e-9 Immunoglobulin light chain (AL) amyloidosis (serum Ig lambda profile);Immunoglobulin light chain (AL) amyloidosis (serum IgG profile); CRC cis rs7208859 0.524 rs11653098 chr17:29122501 C/T cg01831904 chr17:28903510 LRRC37B2 -0.62 -6.41 -0.33 5.13e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs7487075 0.619 rs10748450 chr12:46857102 C/T cg22049899 chr12:47219821 SLC38A4 0.31 5.72 0.3 2.38e-8 Itch intensity from mosquito bite; CRC cis rs9372498 0.536 rs28605789 chr6:118889952 G/A cg15382696 chr6:118971807 C6orf204 0.6 7.65 0.39 2.19e-13 Diastolic blood pressure; CRC cis rs1552244 0.938 rs34750074 chr3:10091740 G/A cg13047869 chr3:10149882 C3orf24 0.56 7.72 0.39 1.4e-13 Alzheimer's disease; CRC trans rs7613875 0.620 rs7624030 chr3:50071279 A/C cg21659725 chr3:3221576 CRBN -0.44 -6.45 -0.34 3.95e-10 Body mass index; CRC trans rs2055729 0.710 rs114038384 chr8:9737519 T/A cg06636001 chr8:8085503 FLJ10661 0.57 6.94 0.36 2.04e-11 Multiple myeloma (hyperdiploidy); CRC cis rs34172651 0.517 rs200526 chr16:24760511 C/T cg04756594 chr16:24857601 SLC5A11 -0.32 -6.77 -0.35 5.89e-11 Intelligence (multi-trait analysis); CRC cis rs758324 0.853 rs4705902 chr5:131150267 C/G cg06307176 chr5:131281290 NA 0.43 6.38 0.33 5.98e-10 Alzheimer's disease in APOE e4- carriers; CRC cis rs7666738 0.830 rs10017201 chr4:98983561 G/A cg17366294 chr4:99064904 C4orf37 0.43 7.33 0.37 1.76e-12 Colonoscopy-negative controls vs population controls; CRC cis rs6951245 0.872 rs75398423 chr7:1098414 T/G cg04025307 chr7:1156635 C7orf50 0.64 6.81 0.35 4.53e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs7618915 0.547 rs62253703 chr3:52632357 T/C cg08222913 chr3:52553049 STAB1 -0.34 -6.19 -0.32 1.77e-9 Bipolar disorder; CRC cis rs1707322 0.655 rs3014240 chr1:46089225 C/G cg03146154 chr1:46216737 IPP -0.66 -9.35 -0.46 1.44e-18 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs9916302 0.851 rs2338795 chr17:37399364 T/G cg03013999 chr17:37608204 MED1 0.47 7.21 0.37 3.86e-12 Glomerular filtration rate (creatinine); CRC cis rs9443645 0.901 rs3805747 chr6:79672522 A/G cg05283184 chr6:79620031 NA -0.58 -9.08 -0.45 1.05e-17 Intelligence (multi-trait analysis); CRC cis rs9311474 0.508 rs17052256 chr3:52593119 A/G cg05573699 chr3:52720067 GNL3;PBRM1 -0.44 -6.45 -0.33 4.06e-10 Electroencephalogram traits; CRC cis rs2249694 0.520 rs10857730 chr10:135326822 T/G cg20169779 chr10:135381914 SYCE1 -0.55 -7.51 -0.38 5.53e-13 Obesity-related traits; CRC cis rs798554 0.679 rs1636250 chr7:2884433 T/C cg04166393 chr7:2884313 GNA12 0.55 7.29 0.37 2.26e-12 Height; CRC cis rs736408 0.812 rs746694 chr3:52826620 C/T cg18404041 chr3:52824283 ITIH1 -0.48 -9.84 -0.48 3.39e-20 Bipolar disorder; CRC cis rs1003719 0.788 rs2835579 chr21:38457965 T/C cg10648535 chr21:38446584 PIGP;TTC3 0.51 7.26 0.37 2.74e-12 Eye color traits; CRC cis rs11608355 0.515 rs6606727 chr12:109941450 T/A cg05360138 chr12:110035743 NA 0.77 8.66 0.43 2.14e-16 Neuroticism; CRC cis rs6840360 0.554 rs4643789 chr4:152726691 C/T cg09659197 chr4:152720779 NA 0.43 8.85 0.44 5.36e-17 Intelligence (multi-trait analysis); CRC cis rs1395 0.778 rs17005956 chr2:27451099 C/T cg14242246 chr2:27434262 C2orf28;SLC5A6 0.42 7.81 0.4 7.61e-14 Blood metabolite levels; CRC cis rs7849270 0.760 rs1075650 chr9:131938913 T/C cg13538475 chr9:131942899 NA 0.31 5.68 0.3 2.97e-8 Blood metabolite ratios; CRC cis rs9611565 0.512 rs6519289 chr22:42170432 A/C cg03806693 chr22:41940476 POLR3H 1.11 13.59 0.6 1.05e-33 Vitiligo; CRC cis rs4713118 0.699 rs200978 chr6:27853168 C/G cg15786705 chr6:28176104 NA 0.56 7.01 0.36 1.32e-11 Parkinson's disease; CRC cis rs1033849 0.507 rs1998478 chr13:24721774 C/T cg14860438 chr13:24731302 NA 0.34 5.65 0.3 3.52e-8 Cerebrospinal fluid biomarker levels; CRC cis rs9911578 1.000 rs4398153 chr17:56968181 T/C cg05425664 chr17:57184151 TRIM37 0.48 7.43 0.38 9.63e-13 Intelligence (multi-trait analysis); CRC cis rs4481887 0.893 rs10736379 chr1:248455876 A/T cg00666640 chr1:248458726 OR2T12 0.53 9.38 0.46 1.07e-18 Common traits (Other); CRC cis rs4853012 0.838 rs60964317 chr2:74343423 A/T cg20891558 chr2:74357851 NA 0.55 8.8 0.44 7.65e-17 Gestational age at birth (maternal effect); CRC cis rs5750830 0.649 rs5757663 chr22:39821319 T/C cg25459000 chr22:39777742 SYNGR1 -0.35 -6.13 -0.32 2.58e-9 Intelligence (multi-trait analysis); CRC cis rs7918232 0.574 rs10458708 chr10:27455605 C/T cg14240646 chr10:27532245 ACBD5 -0.9 -13.62 -0.6 8.26e-34 Breast cancer; CRC cis rs6088590 0.735 rs6060001 chr20:33294353 C/T cg24642439 chr20:33292090 TP53INP2 -0.44 -7.55 -0.38 4.4e-13 Coronary artery disease; CRC cis rs5758511 0.817 rs133291 chr22:42269628 C/T cg00645731 chr22:42541494 CYP2D7P1 0.5 8.06 0.41 1.43e-14 Birth weight; CRC cis rs898097 0.578 rs2380173 chr17:80909157 G/T cg03160526 chr17:80928410 B3GNTL1 -0.47 -7.73 -0.39 1.31e-13 Breast cancer; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg01428115 chr11:46402506 MDK 0.48 6.92 0.36 2.43e-11 Response to antipsychotic treatment; CRC cis rs6500602 0.702 rs11076834 chr16:4549583 C/G cg14951292 chr16:4525986 HMOX2;NMRAL1 0.55 8.4 0.42 1.35e-15 Schizophrenia; CRC cis rs10924970 0.967 rs2152954 chr1:235417780 A/G cg26050004 chr1:235667680 B3GALNT2 0.39 5.78 0.3 1.78e-8 Asthma; CRC cis rs9486719 0.948 rs11152970 chr6:96909077 A/G cg18709589 chr6:96969512 KIAA0776 -0.51 -5.73 -0.3 2.22e-8 Migraine;Coronary artery disease; CRC trans rs2797160 0.967 rs8180614 chr6:126000599 G/C cg05039488 chr6:79577232 IRAK1BP1 -0.5 -7.55 -0.38 4.4e-13 Endometrial cancer; CRC cis rs7131987 0.903 rs2194519 chr12:29423583 C/T cg09582351 chr12:29534625 ERGIC2 0.32 6.85 0.35 3.58e-11 QT interval; CRC cis rs796364 1.000 rs11895190 chr2:200838613 A/G cg23649088 chr2:200775458 C2orf69 -0.56 -5.98 -0.31 5.7e-9 Schizophrenia; CRC trans rs1005277 0.579 rs2472178 chr10:38384750 T/C cg11292332 chr7:45801988 SEPT13 -0.35 -6.33 -0.33 7.9e-10 Extrinsic epigenetic age acceleration; CRC cis rs1550582 0.662 rs7812708 chr8:135500832 C/T cg17885191 chr8:135476712 NA 0.98 13.39 0.59 6.33e-33 Educational attainment; CRC cis rs2629540 0.889 rs7090422 chr10:126439361 T/A cg08799069 chr10:126477246 METTL10 -0.64 -8.77 -0.44 9.63e-17 Cocaine dependence; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg14430982 chr8:145691629 CYHR1;KIFC2 0.5 6.64 0.34 1.29e-10 Anxiety disorder; CRC cis rs6500602 0.702 rs9929475 chr16:4540885 C/T cg14951292 chr16:4525986 HMOX2;NMRAL1 -0.56 -8.64 -0.43 2.47e-16 Schizophrenia; CRC cis rs873946 0.586 rs3793684 chr10:134568645 G/A cg18305652 chr10:134549665 INPP5A 0.49 6.26 0.33 1.23e-9 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CRC cis rs3096299 0.967 rs2965830 chr16:89460290 T/C cg01788221 chr16:89496183 ANKRD11 -0.46 -7.07 -0.36 9.52e-12 Multiple myeloma (IgH translocation); CRC cis rs6089584 0.927 rs1886007 chr20:60581049 G/A cg18761221 chr20:60518478 NA 0.4 6.95 0.36 1.96e-11 Body mass index; CRC cis rs4731207 0.596 rs2402762 chr7:124599846 A/G cg23710748 chr7:124431027 NA -0.39 -6.21 -0.32 1.58e-9 Cutaneous malignant melanoma; CRC cis rs6951245 0.554 rs75075857 chr7:1140298 C/T cg18297960 chr7:1142765 C7orf50 -0.43 -5.97 -0.31 5.99e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs1401999 0.966 rs2292998 chr3:183663833 T/C cg01324343 chr3:183735012 ABCC5 0.81 14.71 0.63 5.61e-38 Anterior chamber depth; CRC cis rs7584330 0.554 rs7598035 chr2:238434942 C/T cg14458575 chr2:238380390 NA 0.52 6.86 0.35 3.51e-11 Prostate cancer; CRC cis rs9303401 0.659 rs34468504 chr17:56648277 C/T cg10487724 chr17:56770010 TEX14;RAD51C 0.78 9.59 0.47 2.24e-19 Cognitive test performance; CRC cis rs4319547 0.956 rs10847179 chr12:123040985 T/C cg23029597 chr12:123009494 RSRC2 -0.62 -7.83 -0.4 6.74e-14 Body mass index; CRC cis rs28493229 0.708 rs4803352 chr19:41159193 C/T cg21869046 chr19:41225005 ITPKC -0.38 -5.87 -0.31 1.08e-8 Kawasaki disease; CRC cis rs11190604 1.000 rs11190599 chr10:102295420 C/T cg07080220 chr10:102295463 HIF1AN 0.47 5.66 0.3 3.31e-8 Palmitoleic acid (16:1n-7) levels; CRC cis rs9341808 0.754 rs3812126 chr6:80952701 A/G cg08355045 chr6:80787529 NA -0.43 -7.18 -0.37 4.62e-12 Sitting height ratio; CRC cis rs3540 0.597 rs11639150 chr15:91042071 C/G cg22089800 chr15:90895588 ZNF774 -0.57 -9.44 -0.46 7.31e-19 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; CRC trans rs9291683 0.509 rs6849717 chr4:9958719 T/C cg26043149 chr18:55253948 FECH -0.53 -8.09 -0.41 1.19e-14 Bone mineral density; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg17001531 chr1:16825540 NA 0.41 6.57 0.34 1.97e-10 Liver disease severity in Alagille syndrome; CRC cis rs7487075 0.964 rs2408497 chr12:46796751 A/G cg17501823 chr12:47219793 SLC38A4 0.32 5.64 0.3 3.58e-8 Itch intensity from mosquito bite; CRC cis rs6964587 0.839 rs2049314 chr7:91464134 C/T cg17063962 chr7:91808500 NA 0.68 10.67 0.51 5.26e-23 Breast cancer; CRC cis rs731174 0.797 rs565316 chr1:38157624 T/C cg06917450 chr1:38156652 C1orf109 -0.52 -7.17 -0.37 5.07e-12 Prostate cancer (SNP x SNP interaction); CRC cis rs13108904 0.967 rs2293635 chr4:1291791 A/G cg02018176 chr4:1364513 KIAA1530 0.47 7.7 0.39 1.56e-13 Obesity-related traits; CRC cis rs875971 0.895 rs10447522 chr7:65796074 A/G cg18876405 chr7:65276391 NA -0.54 -8.67 -0.43 1.96e-16 Aortic root size; CRC cis rs55823223 0.503 rs9906971 chr17:73848477 A/G cg08125733 chr17:73851984 WBP2 0.73 9.39 0.46 1.04e-18 Psoriasis; CRC cis rs7927771 0.965 rs12787112 chr11:47687147 A/G cg18512352 chr11:47633146 NA -0.48 -9.31 -0.46 1.84e-18 Subjective well-being; CRC cis rs3806843 0.520 rs265312 chr5:140296272 T/G cg19875535 chr5:140030758 IK 0.45 6.85 0.35 3.65e-11 Depressive symptoms (multi-trait analysis); CRC cis rs1570884 0.516 rs9316462 chr13:50176321 A/G cg08779649 chr13:50194554 NA 0.45 9.29 0.46 2.21e-18 Sum basophil neutrophil counts;Sum neutrophil eosinophil counts;Neutrophil count;Myeloid white cell count;Granulocyte count; CRC cis rs2652834 1.000 rs2652833 chr15:63396885 C/A cg05507819 chr15:63340323 TPM1 0.46 6.05 0.32 3.88e-9 HDL cholesterol; CRC cis rs6543140 0.964 rs13390895 chr2:103075499 G/A cg03938978 chr2:103052716 IL18RAP 0.41 6.54 0.34 2.37e-10 Blood protein levels; CRC cis rs6570726 0.935 rs382910 chr6:145865941 G/A cg23711669 chr6:146136114 FBXO30 0.71 12.46 0.57 1.8e-29 Lobe attachment (rater-scored or self-reported); CRC cis rs2124969 0.522 rs6432608 chr2:161034991 C/T cg03641300 chr2:160917029 PLA2R1 -0.6 -9.84 -0.48 3.42e-20 Waist circumference adjusted for body mass index; CRC cis rs3736485 0.868 rs9744054 chr15:51933163 C/T cg08986416 chr15:51914746 DMXL2 -0.46 -6.55 -0.34 2.18e-10 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg24937269 chr2:101179488 PDCL3 0.49 6.87 0.35 3.16e-11 Response to antipsychotic treatment; CRC cis rs2842992 0.830 rs2025190 chr6:160138241 C/T cg11366901 chr6:160182831 ACAT2 1.03 14.59 0.63 1.64e-37 Age-related macular degeneration (geographic atrophy); CRC cis rs13191362 1.000 rs34725898 chr6:163127302 C/T cg14584255 chr6:163149320 PACRG;PARK2 0.43 6.28 0.33 1.07e-9 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs875971 1.000 rs11971949 chr7:65626014 A/G cg12463550 chr7:65579703 CRCP -0.49 -7.07 -0.36 9.09e-12 Aortic root size; CRC cis rs6681460 0.934 rs10889635 chr1:67075575 G/A cg02459107 chr1:67143332 SGIP1 0.44 7.45 0.38 8.42e-13 Presence of antiphospholipid antibodies; CRC cis rs6088580 0.602 rs6059840 chr20:33030405 G/A cg24642439 chr20:33292090 TP53INP2 0.36 6.12 0.32 2.61e-9 Glomerular filtration rate (creatinine); CRC cis rs4713118 0.527 rs9461433 chr6:28095172 C/T cg25164649 chr6:28176230 NA 0.76 9.53 0.46 3.71e-19 Parkinson's disease; CRC cis rs1552244 0.554 rs13081079 chr3:10056348 A/G cg08888203 chr3:10149979 C3orf24 0.48 7.18 0.37 4.64e-12 Alzheimer's disease; CRC cis rs9875589 0.509 rs2733555 chr3:14099649 C/T cg14375111 chr3:14165186 TMEM43;CHCHD4 0.4 6.03 0.32 4.48e-9 Ovarian reserve; CRC cis rs514406 0.584 rs7548832 chr1:53193576 A/T cg27535305 chr1:53392650 SCP2 -0.32 -5.7 -0.3 2.64e-8 Monocyte count; CRC cis rs12580194 1.000 rs7968881 chr12:55694434 A/C cg19537932 chr12:55886519 OR6C68 -0.57 -7.9 -0.4 4.11e-14 Cancer; CRC cis rs270601 0.739 rs3900945 chr5:131592870 T/C cg22638593 chr5:131593259 PDLIM4 0.49 9.26 0.45 2.74e-18 Acylcarnitine levels; CRC cis rs3617 0.625 rs6445541 chr3:52880128 G/T cg05573699 chr3:52720067 GNL3;PBRM1 -0.39 -5.73 -0.3 2.22e-8 Red blood cell count;Autism spectrum disorder or schizophrenia; CRC cis rs2559856 1.000 rs2695291 chr12:102087543 G/A cg12924262 chr12:102091054 CHPT1 0.54 8.06 0.41 1.38e-14 Blood protein levels; CRC cis rs6860806 0.507 rs635620 chr5:131720263 A/G cg24060327 chr5:131705240 SLC22A5 0.51 7.67 0.39 2.02e-13 Breast cancer; CRC cis rs113835537 0.877 rs57127845 chr11:66318325 C/T cg22134325 chr11:66188745 NPAS4 0.35 5.75 0.3 2.05e-8 Airway imaging phenotypes; CRC cis rs694739 0.628 rs11606081 chr11:64137875 T/C cg02228329 chr11:64053129 BAD;GPR137 0.5 6.81 0.35 4.64e-11 Alopecia areata;Crohn's disease;Psoriasis vulgaris; CRC cis rs4555082 0.834 rs2735822 chr14:105712734 C/T cg13114125 chr14:105738426 BRF1 -0.82 -11.97 -0.55 1.2e-27 Mean platelet volume;Platelet distribution width; CRC cis rs11971779 0.616 rs6949963 chr7:139054325 C/T cg23387468 chr7:139079360 LUC7L2 0.41 7.04 0.36 1.14e-11 Diisocyanate-induced asthma; CRC trans rs75804782 0.520 rs72987319 chr2:239351143 C/T cg01134436 chr17:81009848 B3GNTL1 0.75 6.8 0.35 4.95e-11 Morning vs. evening chronotype;Chronotype; CRC cis rs12701220 0.894 rs10257744 chr7:1045612 C/T cg26240231 chr7:1148101 C7orf50 -0.43 -5.81 -0.3 1.49e-8 Bronchopulmonary dysplasia; CRC cis rs11719291 0.504 rs34571182 chr3:49209057 T/A cg00383909 chr3:49044727 WDR6 1.05 10.13 0.49 3.69e-21 Cognitive function; CRC cis rs13108904 0.901 rs6826029 chr4:1307689 A/G cg20092199 chr4:1342459 KIAA1530 0.4 7.3 0.37 2.12e-12 Obesity-related traits; CRC cis rs9311474 0.508 rs4687629 chr3:52615227 G/C cg18404041 chr3:52824283 ITIH1 -0.4 -8.45 -0.42 9.79e-16 Electroencephalogram traits; CRC cis rs10256972 0.577 rs6962809 chr7:1208889 A/G cg18402987 chr7:1209562 NA 0.62 9.55 0.47 3.04e-19 Longevity;Endometriosis; CRC cis rs992157 0.798 rs4674284 chr2:219161241 C/T cg13835894 chr2:219148914 PNKD;TMBIM1 -0.34 -6.45 -0.34 3.94e-10 Colorectal cancer; CRC cis rs6723226 0.804 rs17428810 chr2:32736043 T/C cg02381751 chr2:32503542 YIPF4 -0.56 -7.75 -0.39 1.18e-13 Intelligence (multi-trait analysis); CRC cis rs28386778 0.897 rs2584642 chr17:61942427 T/C cg06873352 chr17:61820015 STRADA 0.73 13.55 0.6 1.54e-33 Prudent dietary pattern; CRC cis rs7412746 0.634 rs12096831 chr1:150864113 T/G cg10589385 chr1:150898437 SETDB1 0.33 7.08 0.36 8.55e-12 Melanoma; CRC cis rs1865760 0.865 rs1541987 chr6:25950397 A/G cg16482183 chr6:26056742 HIST1H1C -0.54 -7.9 -0.4 4.19e-14 Height; CRC cis rs870825 0.616 rs6817521 chr4:185649827 A/G cg04058563 chr4:185651563 MLF1IP -0.65 -8.28 -0.42 3.04e-15 Blood protein levels; CRC cis rs262150 0.630 rs2730274 chr7:158796062 C/A cg10570241 chr7:158785291 NA 0.44 7.38 0.38 1.3e-12 Facial morphology (factor 20); CRC cis rs66573146 0.656 rs57454756 chr4:6958582 C/T cg00086871 chr4:6988644 TBC1D14 0.91 6.86 0.35 3.36e-11 Granulocyte percentage of myeloid white cells; CRC cis rs394563 0.726 rs6922130 chr6:149672375 C/G cg07828024 chr6:149772892 ZC3H12D 0.48 9.07 0.45 1.08e-17 Dupuytren's disease; CRC cis rs11190604 1.000 rs11190595 chr10:102291761 T/C cg07080220 chr10:102295463 HIF1AN 0.47 5.65 0.3 3.39e-8 Palmitoleic acid (16:1n-7) levels; CRC cis rs9311474 0.713 rs352165 chr3:52242902 A/G cg18099408 chr3:52552593 STAB1 -0.37 -6.12 -0.32 2.61e-9 Electroencephalogram traits; CRC cis rs4731207 0.623 rs28807101 chr7:124598826 A/G cg23710748 chr7:124431027 NA -0.39 -6.14 -0.32 2.34e-9 Cutaneous malignant melanoma; CRC cis rs4072705 0.614 rs35929043 chr9:127234356 T/C cg13476313 chr9:127244764 NR5A1 0.28 5.64 0.3 3.65e-8 Menarche (age at onset); CRC cis rs17767294 0.612 rs9461424 chr6:27919401 G/A cg02683197 chr6:28174875 NA 0.74 7.48 0.38 6.93e-13 Parkinson's disease; CRC cis rs6582630 0.555 rs35284307 chr12:38509999 T/G cg13010199 chr12:38710504 ALG10B 0.48 6.46 0.34 3.84e-10 Drug-induced liver injury (flucloxacillin); CRC cis rs1577917 0.740 rs2842614 chr6:86306069 G/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.57 -7.9 -0.4 4.37e-14 Response to antipsychotic treatment; CRC cis rs3771570 0.892 rs59715783 chr2:242366262 C/T cg21155796 chr2:242212141 HDLBP 0.66 7.1 0.36 7.64e-12 Prostate cancer; CRC cis rs11229555 0.645 rs34054511 chr11:58204943 A/C cg15696309 chr11:58395628 NA -0.82 -10.44 -0.5 3.27e-22 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; CRC cis rs11155671 0.530 rs9383914 chr6:150207234 T/G cg13206674 chr6:150067644 NUP43 0.48 6.95 0.36 1.93e-11 Testicular germ cell tumor; CRC trans rs11098499 0.739 rs10013032 chr4:120149419 C/T cg25214090 chr10:38739885 LOC399744 -0.42 -6.72 -0.35 7.89e-11 Corneal astigmatism; CRC cis rs3936840 0.565 rs8006911 chr14:102975265 A/G cg18135206 chr14:102964638 TECPR2 0.59 7.59 0.39 3.37e-13 Plateletcrit; CRC cis rs17767392 0.881 rs35589413 chr14:71991676 T/A cg13720639 chr14:72061746 SIPA1L1 -0.47 -6.24 -0.33 1.37e-9 Mitral valve prolapse; CRC cis rs7107174 1.000 rs4945261 chr11:77990260 A/G cg02023728 chr11:77925099 USP35 -0.51 -7.4 -0.38 1.14e-12 Testicular germ cell tumor; CRC cis rs9733 0.818 rs6694531 chr1:150683512 C/A cg17724175 chr1:150552817 MCL1 -0.46 -7.28 -0.37 2.55e-12 Tonsillectomy; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg00300090 chr3:4345167 SETMAR 0.42 6.63 0.34 1.36e-10 Liver disease severity in Alagille syndrome; CRC trans rs2243480 1.000 rs35432774 chr7:65393019 G/C cg10756647 chr7:56101905 PSPH 0.71 7.81 0.4 7.72e-14 Diabetic kidney disease; CRC cis rs929354 0.806 rs28446734 chr7:156996775 T/C cg05182265 chr7:156933206 UBE3C -0.76 -14.36 -0.62 1.17e-36 Body mass index; CRC cis rs7120118 0.517 rs11530168 chr11:47322986 A/G cg25783544 chr11:47291846 MADD 0.62 5.77 0.3 1.81e-8 HDL cholesterol; CRC cis rs2688608 0.592 rs11000759 chr10:75493726 G/A cg16540259 chr10:75572220 NDST2 0.38 5.93 0.31 7.67e-9 Inflammatory bowel disease; CRC cis rs6502050 0.830 rs8074436 chr17:80158422 A/G cg02741985 chr17:80059408 CCDC57 0.42 6.93 0.36 2.24e-11 Life satisfaction; CRC cis rs875971 0.545 rs6969224 chr7:65834998 T/G cg03233332 chr7:66118400 NA -0.42 -5.68 -0.3 2.97e-8 Aortic root size; CRC cis rs2243480 0.764 rs2460423 chr7:65601216 A/T cg12463550 chr7:65579703 CRCP 0.7 6.45 0.34 3.97e-10 Diabetic kidney disease; CRC cis rs7107174 0.792 rs10899488 chr11:78088754 A/G cg02023728 chr11:77925099 USP35 0.44 6.92 0.36 2.32e-11 Testicular germ cell tumor; CRC cis rs1538970 0.924 rs11211118 chr1:45930270 A/C cg05343316 chr1:45956843 TESK2 0.72 9.75 0.47 6.62e-20 Platelet count; CRC cis rs7208859 0.623 rs7219712 chr17:29080570 G/T cg13385521 chr17:29058706 SUZ12P 0.72 8.18 0.41 6.46e-15 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs921968 0.565 rs7599945 chr2:219641528 G/T cg02176678 chr2:219576539 TTLL4 -0.41 -6.6 -0.34 1.62e-10 Mean corpuscular hemoglobin concentration; CRC cis rs9549328 0.700 rs2185001 chr13:113616369 G/T cg24588162 chr13:113633484 MCF2L -0.39 -6.83 -0.35 4.01e-11 Systolic blood pressure; CRC cis rs4713118 0.869 rs2056925 chr6:27690905 A/G cg12172441 chr6:28176163 NA 0.51 6.98 0.36 1.63e-11 Parkinson's disease; CRC cis rs477895 0.713 rs7952318 chr11:63961242 G/A cg18225595 chr11:63971243 STIP1 0.61 8.44 0.42 1.02e-15 Mean platelet volume; CRC cis rs758324 0.738 rs399714 chr5:131318788 C/T cg25547332 chr5:131281432 NA -0.36 -5.72 -0.3 2.41e-8 Alzheimer's disease in APOE e4- carriers; CRC cis rs12580194 0.593 rs60230359 chr12:55736550 T/C cg19537932 chr12:55886519 OR6C68 -0.72 -8.99 -0.44 1.99e-17 Cancer; CRC cis rs9916302 0.904 rs7503069 chr17:37697128 C/G cg07936489 chr17:37558343 FBXL20 -0.85 -13.29 -0.59 1.52e-32 Glomerular filtration rate (creatinine); CRC cis rs9467773 1.000 rs3736782 chr6:26505403 C/A cg09904177 chr6:26538194 HMGN4 0.85 14.75 0.63 3.95e-38 Intelligence (multi-trait analysis); CRC cis rs514406 0.861 rs35517489 chr1:53304062 G/C cg24675658 chr1:53192096 ZYG11B -0.55 -8.29 -0.42 2.89e-15 Monocyte count; CRC cis rs7528419 1.000 rs646776 chr1:109818530 C/T cg00908766 chr1:109817496 CELSR2 0.41 7.22 0.37 3.53e-12 Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease);Myocardial infarction;Lipoprotein-associated phospholipase A2 activity and mass;Lipoprotein-associated phospholipase A2 activity change in response to darapladib treatment in cardiovascular disease;Cholesterol, total;Coronary artery disease; CRC cis rs6582630 0.537 rs66855609 chr12:38299029 T/C cg13010199 chr12:38710504 ALG10B 0.47 6.64 0.34 1.32e-10 Drug-induced liver injury (flucloxacillin); CRC cis rs9914988 0.943 rs7217547 chr17:27106872 C/G cg16670446 chr17:27188758 MIR451;MIR144 0.59 10.06 0.49 6.19e-21 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs12200560 0.505 rs211176 chr6:97073821 G/A cg06623918 chr6:96969491 KIAA0776 0.52 7.82 0.4 7.2e-14 Coronary heart disease; CRC cis rs897984 0.542 rs35713203 chr16:31090407 G/C cg02466173 chr16:30829666 NA -0.58 -8.57 -0.43 4.15e-16 Dementia with Lewy bodies; CRC cis rs4253772 0.530 rs11704350 chr22:46671507 C/T cg24881330 chr22:46731750 TRMU 0.63 5.63 0.3 3.82e-8 LDL cholesterol;Cholesterol, total; CRC cis rs3931020 0.548 rs17618340 chr1:75247617 G/A cg21906852 chr1:75198582 TYW3;CRYZ 0.45 6.09 0.32 3.19e-9 Resistin levels; CRC cis rs11168351 0.927 rs7971880 chr12:48391055 C/T cg15465823 chr12:48382534 COL2A1 0.38 6.26 0.33 1.17e-9 Bipolar disorder and schizophrenia; CRC trans rs7618501 0.633 rs9853222 chr3:50022926 T/C cg21665057 chr3:196295764 WDR53;FBXO45 0.61 9.64 0.47 1.53e-19 Intelligence (multi-trait analysis); CRC trans rs9840812 0.656 rs4678437 chr3:136317665 C/T cg00086297 chr16:3662233 BTBD12 0.48 6.17 0.32 2.01e-9 Fibrinogen levels; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg02619805 chr19:5623015 SAFB2;SAFB 0.41 6.06 0.32 3.77e-9 Response to antipsychotic treatment; CRC cis rs4713118 0.513 rs149945 chr6:28002853 T/C cg02631126 chr6:28058918 ZSCAN12L1 0.23 5.63 0.3 3.89e-8 Parkinson's disease; CRC cis rs2859741 0.546 rs2134846 chr1:37500723 G/A cg09363841 chr1:37513479 NA -0.47 -7.29 -0.37 2.33e-12 Forced expiratory volume in 1 second (environmental tobacco smoke interaction); CRC cis rs4566357 0.595 rs6707286 chr2:227911400 A/G cg11843606 chr2:227700838 RHBDD1 -0.44 -6.85 -0.35 3.54e-11 Coronary artery disease; CRC cis rs989128 0.600 rs9913430 chr17:48628470 A/T cg16068336 chr17:48637367 CACNA1G -0.51 -7.45 -0.38 8.31e-13 Type 2 diabetes; CRC cis rs7666738 0.830 rs6532723 chr4:99052147 A/T cg05340658 chr4:99064831 C4orf37 0.6 9.35 0.46 1.4e-18 Colonoscopy-negative controls vs population controls; CRC cis rs7552404 0.924 rs2275378 chr1:76198436 T/C cg03433033 chr1:76189801 ACADM 0.91 14.15 0.62 7.73e-36 Blood metabolite levels;Acylcarnitine levels; CRC cis rs34864796 0.547 rs200476 chr6:27768348 A/T cg08798685 chr6:27730294 NA -0.5 -6.51 -0.34 2.87e-10 Lung function (FEV1);Lung function (FEV1/FVC);Lung function (FVC); CRC cis rs3785574 0.962 rs9944483 chr17:61783553 G/T cg23090583 chr17:61904693 PSMC5;FTSJ3 -0.61 -8.83 -0.44 6.34e-17 Height; CRC cis rs2179367 0.959 rs521845 chr6:149671698 A/C cg07828024 chr6:149772892 ZC3H12D 0.36 5.99 0.31 5.47e-9 Dupuytren's disease; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg27305525 chr1:154955752 FLAD1 0.51 6.55 0.34 2.21e-10 Thyroid stimulating hormone; CRC trans rs35110281 0.811 rs2838337 chr21:45072621 A/C cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.52 8.83 0.44 6.16e-17 Mean corpuscular volume; CRC cis rs11148252 0.904 rs7321964 chr13:53040822 A/G cg00495681 chr13:53174319 NA 0.71 11.09 0.52 1.69e-24 Lewy body disease; CRC cis rs2404602 0.647 rs2404604 chr15:76991105 A/G cg23625390 chr15:77176239 SCAPER -0.85 -13.48 -0.6 2.9e-33 Blood metabolite levels; CRC cis rs8177253 1.000 rs1358023 chr3:133484393 T/C cg08048268 chr3:133502702 NA -0.37 -7.11 -0.37 7.16e-12 Iron status biomarkers; CRC cis rs9611565 0.921 rs4822021 chr22:41726053 G/A cg06634786 chr22:41940651 POLR3H -0.5 -6.4 -0.33 5.41e-10 Vitiligo; CRC trans rs1945213 0.659 rs11227133 chr11:55836620 T/C cg15704280 chr7:45808275 SEPT13 0.55 6.15 0.32 2.25e-9 Acute lymphoblastic leukemia (childhood); CRC cis rs5769707 0.967 rs1018812 chr22:50010073 C/T cg20744362 chr22:50050164 C22orf34 0.33 6.63 0.34 1.35e-10 Monocyte count;Monocyte percentage of white cells; CRC cis rs763121 0.853 rs5757213 chr22:39053888 C/T cg06544989 chr22:39130855 UNC84B 0.45 6.86 0.35 3.39e-11 Menopause (age at onset); CRC cis rs35306767 0.903 rs12769431 chr10:922633 T/C cg26597838 chr10:835615 NA 0.94 11.56 0.54 3.59e-26 Eosinophil percentage of granulocytes; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg16711694 chr5:34656625 RAI14 0.37 6.11 0.32 2.88e-9 Liver disease severity in Alagille syndrome; CRC cis rs753778 0.628 rs11579 chr8:142205132 G/A cg18755752 chr8:142205143 DENND3 -0.67 -11.76 -0.54 6.83e-27 Reticulocyte fraction of red cells;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; CRC cis rs1401999 1.000 rs1402002 chr3:183642794 A/G cg01324343 chr3:183735012 ABCC5 0.8 14.47 0.62 4.46e-37 Anterior chamber depth; CRC cis rs11031096 0.542 rs10742200 chr11:3989521 A/T cg18678763 chr11:4115507 RRM1 -0.4 -6.7 -0.35 9.07e-11 Mean corpuscular volume;Mean corpuscular hemoglobin; CRC cis rs1577917 1.000 rs1577919 chr6:86757296 C/A cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.54 -6.64 -0.34 1.29e-10 Response to antipsychotic treatment; CRC cis rs1018836 0.632 rs7017295 chr8:91482356 C/T cg16814680 chr8:91681699 NA 0.62 9.79 0.48 4.92e-20 Ejection fraction in Tripanosoma cruzi seropositivity; CRC cis rs13191362 1.000 rs34177053 chr6:163007772 T/C cg23758597 chr6:163146217 PARK2 -0.51 -5.9 -0.31 8.81e-9 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs9487051 0.676 rs2884013 chr6:109599952 C/T cg12927641 chr6:109611667 NA -0.36 -6.32 -0.33 8.39e-10 Reticulocyte fraction of red cells; CRC cis rs62432291 0.614 rs370434 chr6:159654551 C/G cg14500486 chr6:159655392 FNDC1 -0.77 -10.45 -0.5 3.02e-22 Joint mobility (Beighton score); CRC cis rs6500602 0.702 rs3789038 chr16:4546586 C/G cg08645402 chr16:4508243 NA -0.56 -9.19 -0.45 4.4e-18 Schizophrenia; CRC cis rs2455601 0.786 rs3751064 chr11:8958903 T/C cg09997546 chr11:8931473 C11orf17;ST5 -0.53 -7.1 -0.36 7.67e-12 Schizophrenia; CRC cis rs1552244 1.000 rs17032277 chr3:10077023 T/C cg16606324 chr3:10149918 C3orf24 0.73 9.77 0.47 5.73e-20 Alzheimer's disease; CRC cis rs6570726 0.599 rs426371 chr6:145886469 A/G cg13319975 chr6:146136371 FBXO30 0.61 8.76 0.43 1.05e-16 Lobe attachment (rater-scored or self-reported); CRC cis rs7591163 0.959 rs10933217 chr2:228716226 T/C cg23807890 chr2:228736357 WDR69 -0.51 -7.04 -0.36 1.15e-11 Blood pressure; CRC cis rs17065868 0.764 rs60806722 chr13:45021236 A/G cg10246903 chr13:45222710 NA 0.58 6.47 0.34 3.46e-10 Antineutrophil cytoplasmic antibody-associated vasculitis; CRC cis rs8040855 0.627 rs12909130 chr15:85590501 T/C cg10818794 chr15:86012489 AKAP13 -0.43 -5.69 -0.3 2.77e-8 Bulimia nervosa; CRC cis rs10450586 0.932 rs10835153 chr11:27313863 A/T cg10370305 chr11:27303972 NA 0.35 5.69 0.3 2.76e-8 Total body bone mineral density; CRC cis rs853679 0.542 rs2295594 chr6:28053097 G/A cg23161317 chr6:28129485 ZNF389 0.51 6.36 0.33 6.66e-10 Depression; CRC cis rs6701037 0.566 rs10753091 chr1:175134571 T/C cg14847009 chr1:175162515 KIAA0040 0.3 6.66 0.34 1.18e-10 Alcohol dependence; CRC cis rs7216064 0.953 rs11079705 chr17:65835452 A/T cg12091567 chr17:66097778 LOC651250 -0.69 -8.0 -0.4 2.2e-14 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CRC cis rs6912958 0.967 rs6914299 chr6:88149176 T/G cg08069147 chr6:88032118 GJB7;C6orf162 -0.63 -9.61 -0.47 2e-19 Monocyte percentage of white cells; CRC cis rs7692995 1.000 rs35081654 chr4:18017938 A/T cg08925142 chr4:18023851 LCORL -0.51 -5.81 -0.3 1.5e-8 Height; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg26392691 chr15:51915035 DMXL2 0.46 6.79 0.35 5.28e-11 Intelligence (multi-trait analysis); CRC cis rs6502050 0.835 rs4789724 chr17:80150546 G/A cg25804541 chr17:80189381 SLC16A3 -0.3 -5.71 -0.3 2.57e-8 Life satisfaction; CRC trans rs3794271 0.706 rs9971816 chr12:20826911 C/T cg09525994 chr12:48512905 PFKM 0.47 6.71 0.35 8.62e-11 Response to TNF-alpha inhibitors in rheumatoid arthritis; CRC cis rs35110281 0.659 rs11702544 chr21:45091861 C/T cg04455712 chr21:45112962 RRP1B 0.41 8.26 0.41 3.51e-15 Mean corpuscular volume; CRC cis rs908922 0.676 rs945789 chr1:152512705 C/A cg23254163 chr1:152506842 NA 0.45 8.85 0.44 5.3e-17 Hair morphology; CRC trans rs6561151 0.681 rs4942249 chr13:44426804 C/A cg17145862 chr1:211918768 LPGAT1 0.49 6.4 0.33 5.47e-10 Crohn's disease; CRC cis rs6860806 0.507 rs272880 chr5:131670178 C/T cg20512303 chr5:131592959 PDLIM4 0.39 6.75 0.35 6.72e-11 Breast cancer; CRC cis rs478304 0.651 rs11600918 chr11:65511965 A/G cg27068330 chr11:65405492 SIPA1 -0.66 -10.02 -0.48 8.47e-21 Acne (severe); CRC cis rs3806843 0.733 rs801181 chr5:140092814 C/T cg19875535 chr5:140030758 IK -0.54 -8.78 -0.44 9.33e-17 Depressive symptoms (multi-trait analysis); CRC cis rs7666738 0.830 rs13149779 chr4:99010145 G/T cg05340658 chr4:99064831 C4orf37 0.62 9.72 0.47 8.54e-20 Colonoscopy-negative controls vs population controls; CRC trans rs9409565 0.658 rs2809768 chr9:97128369 G/A cg05679027 chr9:99775184 HIATL2 0.44 6.72 0.35 8.19e-11 Colorectal cancer (alcohol consumption interaction); CRC cis rs7613875 0.641 rs6446194 chr3:50067298 T/A cg05623727 chr3:50126028 RBM5 -0.56 -9.66 -0.47 1.33e-19 Body mass index; CRC cis rs7191439 0.858 rs11076701 chr16:88774525 A/G cg27087555 chr16:88793112 FAM38A -1.33 -12.55 -0.57 8.93e-30 Plateletcrit; CRC trans rs6693295 0.729 rs10802325 chr1:246213454 C/A cg17980625 chr11:94965587 SESN3 0.48 6.05 0.32 3.9e-9 Migraine - clinic-based;Migraine with aura; CRC cis rs6598955 0.543 rs6690461 chr1:26543097 T/A cg04990556 chr1:26633338 UBXN11 0.83 9.7 0.47 1.02e-19 Obesity-related traits; CRC cis rs12188164 0.561 rs2721010 chr5:456915 A/G cg26850624 chr5:429559 AHRR 0.52 8.82 0.44 7.02e-17 Cystic fibrosis severity; CRC cis rs9549260 0.709 rs4943795 chr13:41173433 C/T cg21288729 chr13:41239152 FOXO1 -0.4 -6.26 -0.33 1.23e-9 Red blood cell count; CRC cis rs9478638 0.507 rs9371882 chr6:155638741 G/A cg07943832 chr6:155568918 TIAM2 -0.58 -7.38 -0.38 1.27e-12 Electroencephalogram traits; CRC cis rs9469578 1.000 rs6923565 chr6:33707112 G/A cg18708504 chr6:33715942 IP6K3 0.64 7.42 0.38 1.02e-12 Phosphorus levels; CRC cis rs2276314 0.857 rs28530656 chr18:33588700 C/T cg05985134 chr18:33552581 C18orf21 -0.55 -7.42 -0.38 1.03e-12 Endometriosis;Drug-induced torsades de pointes; CRC trans rs3001167 0.867 rs12124558 chr1:194565350 T/G cg19011063 chr5:170171465 NA 0.59 6.09 0.32 3.11e-9 Obesity-related traits; CRC trans rs1455244 0.700 rs7229302 chr18:11508904 G/T cg20483215 chr17:72919318 OTOP2;USH1G 0.42 6.24 0.33 1.35e-9 Schizophrenia; CRC cis rs2658782 0.593 rs2243410 chr11:93255519 T/G cg15737290 chr11:93063684 CCDC67 0.56 8.01 0.4 2.06e-14 Pulmonary function decline; CRC cis rs8177253 0.829 rs9813689 chr3:133514822 C/T cg08048268 chr3:133502702 NA -0.44 -8.09 -0.41 1.14e-14 Iron status biomarkers; CRC cis rs2153535 0.623 rs2152346 chr6:8454652 A/G cg07606381 chr6:8435919 SLC35B3 0.68 10.91 0.52 7.29e-24 Motion sickness; CRC cis rs1129187 1.000 rs1129187 chr6:42932200 G/T cg21280719 chr6:42927975 GNMT -0.44 -9.62 -0.47 1.84e-19 Alzheimer's disease in APOE e4+ carriers; CRC cis rs9300255 0.602 rs1569068 chr12:123632276 A/G cg02203224 chr12:123464087 ARL6IP4;OGFOD2 0.37 5.68 0.3 2.93e-8 Neutrophil percentage of white cells; CRC cis rs4889855 0.614 rs7221663 chr17:78484166 T/C cg16591659 chr17:78472290 NA -0.6 -7.46 -0.38 7.96e-13 Fractional excretion of uric acid; CRC cis rs2735413 0.881 rs4888732 chr16:78080505 A/G cg04733911 chr16:78082701 NA -0.46 -7.67 -0.39 2.02e-13 Systolic blood pressure (alcohol consumption interaction); CRC trans rs10435719 0.902 rs11250179 chr8:11800332 C/T cg06636001 chr8:8085503 FLJ10661 0.49 7.28 0.37 2.46e-12 C-reactive protein levels or triglyceride levels (pleiotropy); CRC cis rs10751667 0.714 rs7933889 chr11:972270 C/T cg01483505 chr11:975446 AP2A2 0.45 7.49 0.38 6.22e-13 Alzheimer's disease (late onset); CRC cis rs728616 0.867 rs1054054 chr10:81682728 C/T cg05935833 chr10:81318306 SFTPA2 -0.72 -7.96 -0.4 2.77e-14 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs847649 0.699 rs10242028 chr7:102527785 C/G cg18108683 chr7:102477205 FBXL13 -0.63 -10.98 -0.52 4.3e-24 Morning vs. evening chronotype; CRC cis rs12474201 0.928 rs12998762 chr2:46938393 A/C cg06386533 chr2:46925753 SOCS5 0.83 13.73 0.6 3.08e-34 Height; CRC cis rs4888262 0.564 rs6564147 chr16:74622586 G/A cg01733217 chr16:74700730 RFWD3 0.79 12.14 0.56 2.89e-28 Testicular germ cell tumor; CRC cis rs5758511 0.689 rs55906806 chr22:42644471 C/T cg00645731 chr22:42541494 CYP2D7P1 0.64 8.48 0.42 7.75e-16 Birth weight; CRC cis rs7091068 0.536 rs7893369 chr10:95410147 A/G cg20715218 chr10:95462985 C10orf4 0.47 5.96 0.31 6.36e-9 Urinary tract infection frequency; CRC trans rs10050311 0.698 rs4693780 chr4:87641219 A/G cg00004207 chr2:38977301 SFRS7 -0.5 -6.19 -0.32 1.75e-9 Insulin-related traits; CRC cis rs4713118 0.615 rs9295747 chr6:27736993 G/T cg25164649 chr6:28176230 NA -0.54 -7.72 -0.39 1.39e-13 Parkinson's disease; CRC cis rs7829975 0.667 rs1877119 chr8:8707197 C/G cg08975724 chr8:8085496 FLJ10661 0.43 6.38 0.33 5.87e-10 Mood instability; CRC cis rs6952808 0.717 rs12534679 chr7:1926745 G/A cg20295408 chr7:1910781 MAD1L1 -0.38 -5.79 -0.3 1.65e-8 Bipolar disorder and schizophrenia; CRC cis rs3768617 0.811 rs12138053 chr1:182979560 C/T ch.1.3577855R chr1:183094577 LAMC1 0.63 9.18 0.45 4.75e-18 Fuchs's corneal dystrophy; CRC cis rs11122272 0.735 rs2808595 chr1:231526238 G/A cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.52 -7.81 -0.4 7.8500000000000006e-14 Hemoglobin concentration; CRC cis rs1577917 0.629 rs7761762 chr6:86205968 C/A cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A 0.47 6.72 0.35 7.95e-11 Response to antipsychotic treatment; CRC cis rs904251 0.523 rs2776920 chr6:37480605 G/A cg25019722 chr6:37503610 NA -0.47 -8.73 -0.43 1.28e-16 Cognitive performance; CRC cis rs2732480 0.557 rs2732441 chr12:48723324 C/G cg24011408 chr12:48396354 COL2A1 0.45 6.1 0.32 3.01e-9 Hemoglobin concentration;Red blood cell count;Hematocrit; CRC cis rs730775 0.505 rs325004 chr6:44270365 C/G cg21130236 chr6:44246755 TMEM151B -0.43 -6.79 -0.35 5.19e-11 Monocyte percentage of white cells;Monocyte count; CRC cis rs6484504 0.625 rs10835766 chr11:31374329 C/A cg14844989 chr11:31128820 NA 0.35 6.18 0.32 1.86e-9 Red blood cell count; CRC cis rs6860806 0.661 rs1588263 chr5:131577158 T/C cg20512303 chr5:131592959 PDLIM4 0.37 7.12 0.37 6.75e-12 Breast cancer; CRC cis rs9486719 0.843 rs2103539 chr6:96844342 T/A cg06623918 chr6:96969491 KIAA0776 0.79 8.57 0.43 4.23e-16 Migraine;Coronary artery disease; CRC cis rs7412746 0.658 rs12405726 chr1:150956128 G/A cg10589385 chr1:150898437 SETDB1 0.32 6.47 0.34 3.52e-10 Melanoma; CRC cis rs3816788 0.792 rs729180 chr8:21817245 C/T cg17168535 chr8:21777572 XPO7 0.59 9.96 0.48 1.3e-20 Lung cancer in ever smokers; CRC cis rs7618915 0.571 rs6798246 chr3:52599922 G/A cg18099408 chr3:52552593 STAB1 -0.45 -7.39 -0.38 1.22e-12 Bipolar disorder; CRC cis rs67311347 1.000 rs9874006 chr3:40471596 G/A cg24209194 chr3:40518798 ZNF619 0.42 6.33 0.33 8.25e-10 Renal cell carcinoma; CRC cis rs9322193 0.884 rs933055 chr6:150130837 A/G cg13206674 chr6:150067644 NUP43 0.57 8.16 0.41 6.99e-15 Lung cancer; CRC cis rs10504229 0.683 rs16921819 chr8:58107936 G/T cg02725872 chr8:58115012 NA -0.66 -11.36 -0.53 1.85e-25 Developmental language disorder (linguistic errors); CRC cis rs67311347 1.000 rs1454497 chr3:40496326 C/T cg09455208 chr3:40491958 NA -0.43 -8.64 -0.43 2.47e-16 Renal cell carcinoma; CRC cis rs7208859 0.623 rs216423 chr17:28942109 G/C cg01831904 chr17:28903510 LRRC37B2 -0.53 -6.32 -0.33 8.47e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC trans rs1814175 0.765 rs1722003 chr11:49895896 G/A cg15704280 chr7:45808275 SEPT13 -1.02 -20.56 -0.75 5.59e-61 Height; CRC trans rs12310399 0.611 rs7961230 chr12:95565867 C/A cg16511708 chr18:23671264 SS18 0.41 5.97 0.31 6.1e-9 Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel + carboplatin); CRC cis rs2932538 0.922 rs7535636 chr1:113101799 C/T cg22162597 chr1:113214053 CAPZA1 -0.71 -10.31 -0.49 8.6e-22 Systolic blood pressure;Diastolic blood pressure;Hypertension;Blood pressure; CRC cis rs4481887 0.893 rs4275482 chr1:248473506 T/C cg13385794 chr1:248469461 NA 0.38 6.58 0.34 1.87e-10 Common traits (Other); CRC cis rs9916302 0.706 rs9646419 chr17:37597185 A/G cg07936489 chr17:37558343 FBXL20 -0.93 -11.84 -0.55 3.62e-27 Glomerular filtration rate (creatinine); CRC cis rs10504229 0.953 rs66676208 chr8:58173866 C/T cg05313129 chr8:58192883 C8orf71 -0.47 -6.99 -0.36 1.49e-11 Developmental language disorder (linguistic errors); CRC cis rs1832871 0.672 rs9457362 chr6:158772052 C/T cg07165851 chr6:158734300 TULP4 0.62 7.81 0.4 7.61e-14 Height; CRC cis rs477895 0.639 rs35858916 chr11:63950529 T/G cg04317338 chr11:64019027 PLCB3 0.6 7.3 0.37 2.25e-12 Mean platelet volume; CRC cis rs7552404 1.000 rs28602663 chr1:76235355 C/T cg22875332 chr1:76189707 ACADM 0.64 8.63 0.43 2.58e-16 Blood metabolite levels;Acylcarnitine levels; CRC cis rs68170813 0.559 rs17350182 chr7:106909637 T/A cg02696742 chr7:106810147 HBP1 -0.6 -6.65 -0.34 1.25e-10 Coronary artery disease; CRC cis rs7705042 0.865 rs6874308 chr5:141506911 C/T cg07392085 chr5:141489673 NDFIP1 0.46 7.27 0.37 2.59e-12 Asthma; CRC cis rs9649213 0.593 rs2394854 chr7:98027306 A/G cg24562669 chr7:97807699 LMTK2 0.43 7.09 0.36 8.16e-12 Prostate cancer (SNP x SNP interaction); CRC cis rs4728302 0.643 rs6978605 chr7:133720125 T/C cg03336402 chr7:133662267 EXOC4 -0.44 -6.83 -0.35 4.19e-11 Intelligence;Intelligence (multi-trait analysis); CRC cis rs6582630 0.519 rs8186881 chr12:38310285 A/G cg26384229 chr12:38710491 ALG10B 0.66 9.38 0.46 1.12e-18 Drug-induced liver injury (flucloxacillin); CRC cis rs7618915 0.571 rs34115864 chr3:52612178 A/G cg08222913 chr3:52553049 STAB1 -0.34 -6.27 -0.33 1.14e-9 Bipolar disorder; CRC cis rs4243830 0.850 rs10779790 chr1:6608435 A/G cg05709478 chr1:6581295 PLEKHG5 -0.57 -6.82 -0.35 4.39e-11 Body mass index; CRC cis rs67340775 0.541 rs200979 chr6:27852357 G/A cg26587870 chr6:27730563 NA -0.56 -6.42 -0.33 4.87e-10 Lung cancer in ever smokers; CRC cis rs3768617 0.528 rs10911240 chr1:183062948 T/C ch.1.3577855R chr1:183094577 LAMC1 0.86 15.19 0.64 7.31e-40 Fuchs's corneal dystrophy; CRC cis rs7762018 0.607 rs6907814 chr6:170058206 G/A cg19338460 chr6:170058176 WDR27 -1.21 -11.51 -0.54 5.31e-26 Thiazide-induced adverse metabolic effects in hypertensive patients; CRC cis rs2204008 0.660 rs2874343 chr12:38239096 C/T cg13010199 chr12:38710504 ALG10B 0.46 5.83 0.31 1.31e-8 Bladder cancer; CRC cis rs1009181 0.585 rs72834696 chr6:26161399 G/A cg00631329 chr6:26305371 NA -0.42 -6.16 -0.32 2.16e-9 Childhood ear infection; CRC cis rs3820068 0.581 rs16851855 chr1:15930869 G/A cg13390004 chr1:15929781 NA 0.51 7.2 0.37 4.22e-12 Systolic blood pressure; CRC trans rs12478296 0.681 rs73007114 chr2:242984903 T/C cg18288967 chr1:45987694 PRDX1 0.67 6.73 0.35 7.56e-11 Obesity-related traits; CRC cis rs2976388 0.609 rs2585150 chr8:143792669 C/T cg15511327 chr8:143859410 LYNX1 0.41 7.33 0.37 1.74e-12 Urinary tract infection frequency; CRC cis rs6076065 0.723 rs6083119 chr20:23390923 T/G cg11657817 chr20:23433608 CST11 0.44 6.31 0.33 9.24e-10 Facial morphology (factor 15, philtrum width); CRC cis rs1153858 1.000 rs4774577 chr15:45644685 A/C cg14582100 chr15:45693742 SPATA5L1 0.28 5.91 0.31 8.44e-9 Homoarginine levels; CRC cis rs10504229 0.683 rs67492041 chr8:58140077 G/A cg04204079 chr8:58130323 NA -0.45 -5.78 -0.3 1.71e-8 Developmental language disorder (linguistic errors); CRC cis rs362272 0.545 rs2748447 chr4:3337831 G/A cg01612440 chr4:3296283 NA 0.4 5.71 0.3 2.54e-8 Serum sulfate level; CRC cis rs28386778 0.591 rs2584619 chr17:61913215 T/A cg11494091 chr17:61959527 GH2 0.6 10.15 0.49 3.03e-21 Prudent dietary pattern; CRC cis rs35306767 0.903 rs7077278 chr10:911291 A/G cg26597838 chr10:835615 NA -0.93 -11.32 -0.53 2.55e-25 Eosinophil percentage of granulocytes; CRC trans rs11148252 0.532 rs9536262 chr13:53303074 A/C cg18335740 chr13:41363409 SLC25A15 -0.76 -14.41 -0.62 7.91e-37 Lewy body disease; CRC cis rs28386778 0.897 rs2236737 chr17:61938100 C/T cg22520471 chr17:61851767 DDX42;CCDC47 0.73 11.49 0.54 6.58e-26 Prudent dietary pattern; CRC trans rs877282 0.945 rs10904550 chr10:774177 C/T cg22713356 chr15:30763199 NA 1.14 14.61 0.63 1.32e-37 Uric acid levels; CRC cis rs919433 0.963 rs10199410 chr2:198155776 A/T cg03934865 chr2:198174659 NA -0.45 -8.05 -0.41 1.53e-14 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC cis rs10905065 0.965 rs7078711 chr10:5744985 C/G cg11519256 chr10:5708881 ASB13 0.46 6.63 0.34 1.38e-10 Menopause (age at onset); CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg04348427 chr16:3450780 ZNF174;ZNF434 0.44 6.09 0.32 3.1e-9 Anxiety disorder; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg02466933 chr2:9770529 YWHAQ 0.38 6.82 0.35 4.46e-11 Liver disease severity in Alagille syndrome; CRC cis rs769267 0.566 rs7249692 chr19:19670688 T/C cg03709012 chr19:19516395 GATAD2A -0.54 -7.26 -0.37 2.86e-12 Tonsillectomy; CRC cis rs6580649 1.000 rs6580647 chr12:48403229 G/T cg05342945 chr12:48394962 COL2A1 0.45 6.43 0.33 4.6e-10 Lung cancer; CRC cis rs1532331 0.865 rs4866971 chr5:43151537 C/T cg09164108 chr5:43007320 NA 0.38 5.82 0.31 1.42e-8 Menarche (age at onset); CRC cis rs2976388 0.590 rs3758082 chr8:143824483 A/G cg10596483 chr8:143751796 JRK -0.45 -6.4 -0.33 5.49e-10 Urinary tract infection frequency; CRC cis rs9649213 0.593 rs13246868 chr7:97986453 T/C cg00277769 chr7:97922759 BAIAP2L1 -0.6 -10.39 -0.5 4.76e-22 Prostate cancer (SNP x SNP interaction); CRC cis rs2075371 1.000 rs2241336 chr7:133979578 A/G cg20476274 chr7:133979776 SLC35B4 0.81 14.84 0.63 1.63e-38 Mean platelet volume; CRC cis rs2408955 0.542 rs7975632 chr12:48443048 C/T cg24011408 chr12:48396354 COL2A1 0.43 6.26 0.33 1.18e-9 Glycated hemoglobin levels; CRC cis rs561341 1.000 rs498391 chr17:30328704 G/A cg00745463 chr17:30367425 LRRC37B -0.88 -9.6 -0.47 2.14e-19 Hip circumference adjusted for BMI; CRC cis rs6496667 0.865 rs1971899 chr15:90890664 C/A cg04176472 chr15:90893244 GABARAPL3 0.56 8.57 0.43 4.14e-16 Rheumatoid arthritis; CRC trans rs17112901 1.000 rs2862985 chr10:102062809 G/A cg12052765 chr10:50816963 SLC18A3;CHAT -0.47 -6.04 -0.32 4.27e-9 Obesity-related traits; CRC cis rs6940638 0.688 rs1028308 chr6:27129757 G/A cg12292205 chr6:26970375 C6orf41 -0.47 -6.54 -0.34 2.33e-10 Intelligence (multi-trait analysis); CRC cis rs9911578 1.000 rs8071916 chr17:56660279 A/G cg05425664 chr17:57184151 TRIM37 -0.49 -7.85 -0.4 5.9e-14 Intelligence (multi-trait analysis); CRC cis rs597539 0.652 rs611046 chr11:68631704 A/G cg21963583 chr11:68658836 MRPL21 0.55 9.62 0.47 1.88e-19 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs3812049 0.693 rs9327468 chr5:127441861 C/A cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.72 8.84 0.44 5.83e-17 Lymphocyte counts;Red cell distribution width; CRC trans rs7937682 0.889 rs7948236 chr11:111499933 C/A cg18187862 chr3:45730750 SACM1L 0.49 7.0 0.36 1.4e-11 Primary sclerosing cholangitis; CRC cis rs559928 0.606 rs12419038 chr11:63912736 A/G cg19465662 chr11:63993652 NUDT22;TRPT1 0.61 6.09 0.32 3.18e-9 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; CRC cis rs501120 0.584 rs1746042 chr10:44731897 C/T cg09554077 chr10:44749378 NA 0.62 6.84 0.35 3.9e-11 Coronary artery disease;Coronary heart disease; CRC cis rs9534288 0.830 rs2296641 chr13:46632226 A/C cg15192986 chr13:46630673 CPB2 -0.78 -10.96 -0.52 5.02e-24 Blood protein levels; CRC cis rs10504229 0.639 rs2318146 chr8:58114873 T/G cg04204079 chr8:58130323 NA -0.45 -5.84 -0.31 1.27e-8 Developmental language disorder (linguistic errors); CRC cis rs7208859 0.573 rs7214313 chr17:29138596 T/C cg01831904 chr17:28903510 LRRC37B2 -0.63 -6.59 -0.34 1.78e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs9311676 0.632 rs62258094 chr3:58371770 T/G cg06643156 chr3:58380774 PXK 0.42 6.39 0.33 5.78e-10 Systemic lupus erythematosus; CRC cis rs4689388 0.581 rs1801212 chr4:6302519 C/T cg00701064 chr4:6280414 WFS1 0.6 7.93 0.4 3.53e-14 Type 2 diabetes and other traits;Type 2 diabetes; CRC cis rs12900413 0.687 rs35562959 chr15:90310537 C/T cg24249390 chr15:90295951 MESP1 -0.58 -9.31 -0.46 1.9e-18 Coronary artery aneurysm in Kawasaki disease; CRC cis rs7589728 1.000 rs12473740 chr2:88527647 A/G cg04511125 chr2:88470314 THNSL2 0.73 7.5 0.38 5.81e-13 Plasma clusterin levels; CRC cis rs3733585 0.699 rs60045583 chr4:9971950 G/A cg11266682 chr4:10021025 SLC2A9 -0.46 -9.44 -0.46 7.1e-19 Cleft plate (environmental tobacco smoke interaction); CRC cis rs11155671 0.530 rs7768626 chr6:150207962 G/T cg13206674 chr6:150067644 NUP43 0.48 6.95 0.36 1.93e-11 Testicular germ cell tumor; CRC cis rs2836950 0.509 rs4816618 chr21:40599529 G/A cg11890956 chr21:40555474 PSMG1 -0.68 -10.21 -0.49 1.93e-21 Menarche (age at onset); CRC cis rs1865760 0.532 rs9295687 chr6:26082710 T/C cg16482183 chr6:26056742 HIST1H1C 0.52 7.58 0.39 3.66e-13 Height; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg09018467 chr17:55055306 SCPEP1 0.43 5.99 0.31 5.65e-9 Response to antipsychotic treatment; CRC cis rs56399783 0.901 rs17132744 chr7:2874982 T/C cg19731401 chr7:2775893 GNA12 0.56 6.09 0.32 3.16e-9 Childhood ear infection; CRC cis rs6089584 0.854 rs8117075 chr20:60613766 T/C cg13770153 chr20:60521292 NA -0.59 -8.8 -0.44 8.12e-17 Body mass index; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg04267590 chr5:14581942 FAM105A 0.38 6.05 0.32 4e-9 Liver disease severity in Alagille syndrome; CRC cis rs763121 0.752 rs6001190 chr22:39073811 T/C cg06544989 chr22:39130855 UNC84B 0.45 6.85 0.35 3.58e-11 Menopause (age at onset); CRC cis rs2011503 0.941 rs56044734 chr19:19366927 G/A cg11584989 chr19:19387371 SF4 0.56 6.67 0.34 1.11e-10 Bipolar disorder; CRC cis rs881375 0.678 rs10760128 chr9:123696325 C/T cg09419670 chr9:123605666 PSMD5;LOC253039 0.5 7.89 0.4 4.46e-14 Rheumatoid arthritis; CRC cis rs2479724 0.811 rs6905726 chr6:41750812 T/C cg17623882 chr6:41773611 USP49 0.52 8.65 0.43 2.33e-16 Menarche (age at onset); CRC cis rs11098499 0.954 rs3733524 chr4:120423729 T/C cg09307838 chr4:120376055 NA 0.75 11.25 0.53 4.57e-25 Corneal astigmatism; CRC cis rs13256369 0.950 rs12548792 chr8:8568031 T/C cg00074818 chr8:8560427 CLDN23 0.39 7.0 0.36 1.48e-11 Obesity-related traits; CRC cis rs4713118 0.868 rs7756968 chr6:27734954 C/G cg25164649 chr6:28176230 NA 0.69 7.78 0.39 9.77e-14 Parkinson's disease; CRC cis rs10504229 0.683 rs56408763 chr8:58137276 G/A cg02290350 chr8:58132656 NA -0.58 -8.16 -0.41 7.29e-15 Developmental language disorder (linguistic errors); CRC cis rs2976388 0.669 rs2976391 chr8:143762724 C/A cg15511327 chr8:143859410 LYNX1 0.35 6.16 0.32 2.09e-9 Urinary tract infection frequency; CRC cis rs2991971 0.810 rs12119202 chr1:45925931 A/T cg24296786 chr1:45957014 TESK2 -0.5 -7.55 -0.38 4.37e-13 High light scatter reticulocyte count; CRC cis rs875971 0.522 rs1617484 chr7:65463095 G/A cg18876405 chr7:65276391 NA 0.66 12.19 0.56 1.78e-28 Aortic root size; CRC cis rs17345786 0.861 rs11711808 chr3:101235101 T/C cg11279151 chr3:101281821 RG9MTD1 -0.66 -8.08 -0.41 1.27e-14 Colonoscopy-negative controls vs population controls; CRC cis rs9549328 0.800 rs9549617 chr13:113628070 C/A cg08614441 chr13:113633676 MCF2L -0.53 -9.35 -0.46 1.43e-18 Systolic blood pressure; CRC cis rs12200560 0.505 rs211163 chr6:97067654 A/G cg06623918 chr6:96969491 KIAA0776 0.47 6.79 0.35 5.13e-11 Coronary heart disease; CRC cis rs8177253 0.829 rs9882812 chr3:133506127 A/G cg08048268 chr3:133502702 NA -0.46 -8.58 -0.43 3.72e-16 Iron status biomarkers; CRC cis rs9916302 0.851 rs4794810 chr17:37603774 T/C cg03013999 chr17:37608204 MED1 0.45 6.77 0.35 5.76e-11 Glomerular filtration rate (creatinine); CRC cis rs4953076 0.573 rs6544746 chr2:44407985 C/T cg04920474 chr2:44395004 PPM1B 0.55 7.37 0.38 1.41e-12 Height; CRC cis rs7208859 0.673 rs9889755 chr17:29234505 A/G cg13385521 chr17:29058706 SUZ12P -0.59 -7.48 -0.38 7.04e-13 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs7926971 0.631 rs7938009 chr11:12660882 C/T cg25843174 chr11:12811716 TEAD1 0.33 5.93 0.31 7.58e-9 Height; CRC cis rs17021463 0.902 rs2016483 chr4:95229039 A/T cg11021082 chr4:95130006 SMARCAD1 -0.54 -8.49 -0.42 7.16e-16 Testicular germ cell tumor; CRC cis rs736408 0.648 rs3774355 chr3:52817778 G/A cg18099408 chr3:52552593 STAB1 -0.44 -6.81 -0.35 4.61e-11 Bipolar disorder; CRC cis rs589448 0.934 rs554591 chr12:69753847 T/C cg20891283 chr12:69753455 YEATS4 0.99 21.34 0.76 4.82e-64 Cerebrospinal fluid biomarker levels; CRC cis rs1552244 1.000 rs3826 chr3:10141065 T/G cg16606324 chr3:10149918 C3orf24 0.69 9.75 0.47 6.97e-20 Alzheimer's disease; CRC cis rs34375054 0.573 rs12581367 chr12:125654641 T/C cg25124228 chr12:125621409 AACS -0.53 -6.44 -0.33 4.16e-10 Post bronchodilator FEV1/FVC ratio; CRC cis rs79839061 0.656 rs11726508 chr4:888937 C/T cg07828340 chr4:882639 GAK 0.91 9.49 0.46 4.86e-19 Intelligence (multi-trait analysis); CRC trans rs9650657 0.644 rs7012206 chr8:10697015 A/G cg06636001 chr8:8085503 FLJ10661 -0.39 -6.04 -0.32 4.22e-9 Neuroticism; CRC cis rs9354308 0.901 rs55832318 chr6:66560086 A/G cg07460842 chr6:66804631 NA 0.45 5.69 0.3 2.87e-8 Metabolite levels; CRC cis rs736408 0.660 rs2019065 chr3:52809525 C/T cg05573699 chr3:52720067 GNL3;PBRM1 0.43 6.3 0.33 9.28e-10 Bipolar disorder; CRC cis rs5750830 0.569 rs5750809 chr22:39791491 T/G cg11247378 chr22:39784982 NA -0.43 -7.78 -0.39 9.34e-14 Intelligence (multi-trait analysis); CRC cis rs61897795 0.657 rs174589 chr11:61615803 C/G cg00603274 chr11:61596626 FADS2 0.53 6.47 0.34 3.53e-10 Neutrophil count;Sum basophil neutrophil counts; CRC cis rs7737355 0.947 rs10054733 chr5:130989426 C/T cg06307176 chr5:131281290 NA 0.41 5.89 0.31 9.38e-9 Life satisfaction; CRC cis rs10242455 0.571 rs45593341 chr7:99304911 C/A cg18809830 chr7:99032528 PTCD1 -0.95 -7.28 -0.37 2.47e-12 Blood metabolite levels; CRC cis rs6964587 1.000 rs12540565 chr7:91633213 T/G cg17063962 chr7:91808500 NA 0.8 14.23 0.62 3.79e-36 Breast cancer; CRC cis rs2228479 0.850 rs17227263 chr16:89810598 G/A cg19635926 chr16:89946313 TCF25 0.66 5.98 0.31 5.71e-9 Skin colour saturation; CRC cis rs6938 0.596 rs11630918 chr15:75155896 C/T cg17294928 chr15:75287854 SCAMP5 0.53 8.18 0.41 6.34e-15 Breast cancer; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg08320164 chr19:18228740 MAST3 0.41 6.89 0.36 2.92e-11 Liver disease severity in Alagille syndrome; CRC cis rs9311474 0.607 rs11711421 chr3:52561779 C/T cg08222913 chr3:52553049 STAB1 -0.36 -6.87 -0.35 3.15e-11 Electroencephalogram traits; CRC cis rs2952156 0.920 rs732084 chr17:37834357 A/C cg07936489 chr17:37558343 FBXL20 -0.41 -5.95 -0.31 6.96e-9 Asthma; CRC cis rs11212617 0.905 rs1893813 chr11:108054604 A/G cg01991180 chr11:108092276 ATM;NPAT 0.39 5.71 0.3 2.48e-8 Response to metformin in type 2 diabetes (glycemic); CRC cis rs9308731 0.644 rs3789061 chr2:111918230 T/C cg18646521 chr2:111875858 NA 0.4 6.33 0.33 8.21e-10 Chronic lymphocytic leukemia; CRC cis rs3751196 0.808 rs78288940 chr12:104211454 T/C cg02344784 chr12:104178138 NT5DC3 0.71 7.54 0.38 4.58e-13 Sense of smell; CRC cis rs9287719 0.967 rs4405729 chr2:10755779 A/G cg00105475 chr2:10696890 NA 0.45 7.17 0.37 4.85e-12 Prostate cancer; CRC cis rs11212617 0.967 rs3781868 chr11:108059569 T/G cg12106634 chr11:108092400 ATM;NPAT 0.42 6.3 0.33 9.48e-10 Response to metformin in type 2 diabetes (glycemic); CRC cis rs881375 0.900 rs1930786 chr9:123691469 C/G cg09419670 chr9:123605666 PSMD5;LOC253039 0.58 8.56 0.43 4.42e-16 Rheumatoid arthritis; CRC cis rs727505 1.000 rs66665074 chr7:124550526 C/T cg23710748 chr7:124431027 NA -0.8 -14.1 -0.61 1.19e-35 Lewy body disease; CRC cis rs7591163 1.000 rs6436741 chr2:228714598 G/A cg20647610 chr2:228736258 WDR69 -0.5 -6.76 -0.35 6.37e-11 Blood pressure; CRC cis rs6952808 0.717 rs6967442 chr7:1926090 A/G cg22963979 chr7:1858916 MAD1L1 -0.47 -7.68 -0.39 1.78e-13 Bipolar disorder and schizophrenia; CRC cis rs9905704 0.627 rs1267543 chr17:56656624 A/G cg12560992 chr17:57184187 TRIM37 -0.51 -6.03 -0.32 4.46e-9 Testicular germ cell tumor; CRC cis rs977987 0.800 rs12935787 chr16:75332335 C/T cg03315344 chr16:75512273 CHST6 0.54 9.05 0.45 1.24e-17 Dupuytren's disease; CRC cis rs13256369 0.901 rs12681327 chr8:8566414 G/T cg18904891 chr8:8559673 CLDN23 0.54 7.06 0.36 1.03e-11 Obesity-related traits; CRC cis rs4665809 0.556 rs4665314 chr2:26415912 T/C cg04944784 chr2:26401820 FAM59B -0.84 -10.81 -0.51 1.64e-23 Gut microbiome composition (summer); CRC cis rs7586879 0.929 rs6545807 chr2:25124358 C/T cg22495460 chr2:25135724 ADCY3 -0.72 -11.83 -0.55 3.81e-27 Body mass index; CRC trans rs7726839 0.540 rs11750321 chr5:599196 C/T cg11887960 chr12:57824829 NA 0.59 6.56 0.34 2.05e-10 Obesity-related traits; CRC cis rs6121246 0.954 rs6058470 chr20:30416827 A/T cg13852791 chr20:30311386 BCL2L1 0.6 9.84 0.48 3.28e-20 Mean corpuscular hemoglobin; CRC cis rs2624839 0.704 rs12632110 chr3:50224225 A/G cg05623727 chr3:50126028 RBM5 -0.37 -5.94 -0.31 7.09e-9 Intelligence (multi-trait analysis); CRC cis rs7119 0.717 rs12911963 chr15:77807175 G/C cg10437265 chr15:77819839 NA 0.67 11.95 0.55 1.41e-27 Type 2 diabetes; CRC cis rs7044106 0.762 rs12003646 chr9:123470621 A/G cg09419670 chr9:123605666 PSMD5;LOC253039 0.69 10.42 0.5 3.6e-22 Hip circumference adjusted for BMI; CRC cis rs10504229 0.683 rs73605816 chr8:58117167 T/C cg02290350 chr8:58132656 NA -0.58 -8.16 -0.41 7.29e-15 Developmental language disorder (linguistic errors); CRC cis rs2811415 0.597 rs13059751 chr3:127782662 T/C cg13719885 chr3:127795394 NA -0.39 -5.95 -0.31 6.69e-9 Lung function (FEV1/FVC); CRC cis rs9488822 0.702 rs10872141 chr6:116323246 C/A cg26893134 chr6:116381904 FRK 0.26 7.58 0.39 3.52e-13 Cholesterol, total;LDL cholesterol; CRC trans rs2832077 0.943 rs11701445 chr21:30160807 C/T cg14791747 chr16:20752902 THUMPD1 0.54 6.75 0.35 6.85e-11 Cognitive test performance; CRC cis rs7662987 0.517 rs1311617 chr4:100012425 T/G cg13256891 chr4:100009986 ADH5 0.63 8.4 0.42 1.39e-15 Smoking initiation; CRC cis rs3181245 0.641 rs3756821 chr6:24646821 C/T cg16906346 chr6:24646782 KIAA0319 -0.57 -8.83 -0.44 6.32e-17 Colorectal or endometrial cancer; CRC cis rs7771547 0.519 rs12206445 chr6:36379628 G/A cg07856975 chr6:36356162 ETV7 0.49 5.96 0.31 6.63e-9 Platelet distribution width; CRC cis rs17376456 0.825 rs35426871 chr5:93291613 C/T cg09848695 chr5:92956644 FAM172A;MIR2277 0.67 5.75 0.3 2.07e-8 Diabetic retinopathy; CRC cis rs6951245 1.000 rs76214082 chr7:1102097 T/A cg21664854 chr7:1097933 C7orf50;GPR146 0.77 8.8 0.44 7.85e-17 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs853679 0.760 rs9357067 chr6:28210293 C/G cg21251018 chr6:28226885 NKAPL 0.51 5.95 0.31 6.9e-9 Depression; CRC cis rs6694672 1.000 rs1759007 chr1:197027606 C/T cg13682187 chr1:196946512 CFHR5 -0.5 -8.04 -0.41 1.65e-14 Asthma; CRC cis rs3617 0.625 rs11922961 chr3:52868610 T/C cg18099408 chr3:52552593 STAB1 0.35 5.97 0.31 6.26e-9 Red blood cell count;Autism spectrum disorder or schizophrenia; CRC cis rs478304 0.934 rs570954 chr11:65498261 A/G cg27068330 chr11:65405492 SIPA1 0.43 6.35 0.33 7.22e-10 Acne (severe); CRC cis rs10504229 0.728 rs59266065 chr8:58156236 A/G cg22535103 chr8:58192502 C8orf71 -0.7 -8.41 -0.42 1.3e-15 Developmental language disorder (linguistic errors); CRC cis rs79149102 0.579 rs7342601 chr15:75306795 G/T cg09165964 chr15:75287851 SCAMP5 0.53 5.88 0.31 9.95e-9 Lung cancer; CRC cis rs597539 0.689 rs596874 chr11:68630874 C/T cg06028808 chr11:68637592 NA -0.37 -6.27 -0.33 1.12e-9 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs1030877 0.515 rs2576741 chr2:105897964 T/C cg02079111 chr2:105885981 TGFBRAP1 0.51 7.14 0.37 5.89e-12 Obesity-related traits; CRC cis rs875971 0.964 rs778735 chr7:65814809 C/A cg18912574 chr7:65842487 NCRNA00174 0.36 6.14 0.32 2.34e-9 Aortic root size; CRC cis rs2549003 0.674 rs960757 chr5:131826310 G/A cg00255919 chr5:131827918 IRF1 0.59 11.64 0.54 1.89e-26 Asthma (sex interaction); CRC trans rs34043159 0.965 rs2068397 chr2:102378744 C/A cg23013864 chr6:17393396 CAP2 0.41 5.99 0.31 5.58e-9 Parkinson's disease; CRC cis rs6502050 0.835 rs12600852 chr17:80104593 G/A cg25804541 chr17:80189381 SLC16A3 -0.31 -5.97 -0.31 6.08e-9 Life satisfaction; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg00462311 chr14:24837184 NFATC4 -0.43 -6.63 -0.34 1.41e-10 Liver disease severity in Alagille syndrome; CRC cis rs11098499 0.863 rs3775844 chr4:120428033 G/A cg24375607 chr4:120327624 NA 0.47 7.16 0.37 5.26e-12 Corneal astigmatism; CRC cis rs10208940 0.920 rs35118992 chr2:68699460 G/A cg12452813 chr2:68675892 NA 0.52 6.43 0.33 4.44e-10 Urate levels in lean individuals; CRC cis rs28386778 0.830 rs6504180 chr17:61813169 T/C cg11494091 chr17:61959527 GH2 0.59 9.98 0.48 1.15e-20 Prudent dietary pattern; CRC cis rs7487075 0.859 rs7968283 chr12:46759136 A/G cg22049899 chr12:47219821 SLC38A4 0.34 6.41 0.33 5.1e-10 Itch intensity from mosquito bite; CRC cis rs354225 0.597 rs4347868 chr2:54830616 G/A cg26097391 chr2:54893211 SPTBN1 0.4 5.99 0.31 5.36e-9 Schizophrenia; CRC cis rs6570726 0.791 rs9399558 chr6:145911730 T/C cg13319975 chr6:146136371 FBXO30 -0.44 -6.44 -0.33 4.13e-10 Lobe attachment (rater-scored or self-reported); CRC cis rs1538970 1.000 rs11211101 chr1:45849311 C/G cg05343316 chr1:45956843 TESK2 0.68 9.17 0.45 5.48e-18 Platelet count; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg14760355 chr2:176046503 ATP5G3 0.42 5.96 0.31 6.39e-9 Intelligence (multi-trait analysis); CRC cis rs2549003 1.000 rs2070724 chr5:131822072 A/G cg00255919 chr5:131827918 IRF1 0.59 11.92 0.55 1.77e-27 Asthma (sex interaction); CRC cis rs1215050 0.791 rs260889 chr4:98742340 A/G cg05340658 chr4:99064831 C4orf37 0.47 6.88 0.35 3.09e-11 Waist-to-hip ratio adjusted for body mass index; CRC trans rs2228479 0.850 rs2238532 chr16:89863672 T/C cg24644049 chr4:85504048 CDS1 0.86 7.2 0.37 4.07e-12 Skin colour saturation; CRC cis rs294883 0.821 rs211494 chr6:159671092 C/T cg14500486 chr6:159655392 FNDC1 -0.38 -6.33 -0.33 7.81e-10 Coronary artery disease; CRC cis rs780096 0.546 rs1104 chr2:27599875 T/G cg27432699 chr2:27873401 GPN1 -0.5 -7.56 -0.38 4.14e-13 Total body bone mineral density; CRC cis rs798554 0.757 rs2533879 chr7:2859847 G/A cg17321639 chr7:2759063 NA -0.51 -6.76 -0.35 6.16e-11 Height; CRC trans rs2832077 0.527 rs2738953 chr21:30238363 G/C cg14791747 chr16:20752902 THUMPD1 -0.64 -10.1 -0.49 4.66e-21 Cognitive test performance; CRC cis rs938554 0.868 rs734553 chr4:9923004 G/T cg11266682 chr4:10021025 SLC2A9 0.36 5.79 0.3 1.65e-8 Blood metabolite levels; CRC cis rs9399135 0.967 rs6910530 chr6:135332770 C/T cg22676075 chr6:135203613 NA 0.46 7.15 0.37 5.55e-12 Red blood cell count; CRC cis rs9640161 0.702 rs1962004 chr7:150020381 G/A cg13722127 chr7:150037890 RARRES2 0.53 7.96 0.4 2.83e-14 Blood protein levels;Circulating chemerin levels; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg22251877 chr8:125551349 TATDN1;NDUFB9 0.37 6.0 0.31 5.26e-9 Liver disease severity in Alagille syndrome; CRC cis rs35306767 0.714 rs12783621 chr10:1083304 C/T cg26597838 chr10:835615 NA 0.66 8.62 0.43 2.81e-16 Eosinophil percentage of granulocytes; CRC cis rs9911578 0.935 rs304261 chr17:56813782 A/G cg05425664 chr17:57184151 TRIM37 -0.49 -7.66 -0.39 2.13e-13 Intelligence (multi-trait analysis); CRC cis rs2180341 0.924 rs9285459 chr6:127631113 T/C cg27446573 chr6:127587934 RNF146 0.99 14.65 0.63 8.94e-38 Breast cancer; CRC trans rs9650657 0.513 rs7005884 chr8:10796472 A/G cg16141378 chr3:129829833 LOC729375 0.41 6.04 0.32 4.19e-9 Neuroticism; CRC cis rs10504229 0.953 rs6990806 chr8:58183113 G/A cg22535103 chr8:58192502 C8orf71 -0.82 -12.27 -0.56 9.63e-29 Developmental language disorder (linguistic errors); CRC cis rs11650494 1.000 rs11650494 chr17:47345186 G/A cg08112188 chr17:47440006 ZNF652 0.81 8.2 0.41 5.4e-15 Prostate cancer; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg02735133 chr16:23652915 PALB2;DCTN5 0.47 6.57 0.34 2.01e-10 Response to antipsychotic treatment; CRC cis rs72781680 0.898 rs17509001 chr2:24021231 T/C cg08917208 chr2:24149416 ATAD2B 0.86 8.58 0.43 3.88e-16 Lymphocyte counts; CRC cis rs972578 0.868 rs2273143 chr22:43280650 T/C cg01576275 chr22:43409880 NA -0.41 -6.44 -0.33 4.16e-10 Mean platelet volume; CRC cis rs2949837 0.504 rs2342396 chr7:45968087 C/G cg04727332 chr7:45960243 IGFBP3 0.35 5.67 0.3 3.09e-8 Sitting height ratio; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg00454517 chr12:122607850 MLXIP 0.43 6.51 0.34 2.75e-10 Response to antipsychotic treatment; CRC cis rs7917772 0.503 rs7068535 chr10:104349127 C/T cg22532475 chr10:104410764 TRIM8 -0.36 -6.56 -0.34 2.14e-10 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC cis rs10078 0.559 rs2037077 chr5:447226 A/G cg26072250 chr5:443457 EXOC3;C5orf55 0.59 6.1 0.32 2.92e-9 Fat distribution (HIV); CRC cis rs6598955 0.671 rs11247900 chr1:26612460 G/A cg04990556 chr1:26633338 UBXN11 0.55 5.86 0.31 1.15e-8 Obesity-related traits; CRC cis rs9733 0.596 rs12086630 chr1:150650955 T/C cg15448220 chr1:150897856 SETDB1 0.45 6.43 0.33 4.42e-10 Tonsillectomy; CRC cis rs4974559 0.790 rs7654152 chr4:1325042 G/A cg02980000 chr4:1222292 CTBP1 0.78 8.68 0.43 1.91e-16 Systolic blood pressure; CRC cis rs11229555 0.645 rs1986404 chr11:58194614 T/C cg15696309 chr11:58395628 NA -0.9 -11.45 -0.53 8.8e-26 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; CRC cis rs9768139 0.708 rs10233815 chr7:158114348 C/T cg23298862 chr7:158159286 PTPRN2 0.39 6.16 0.32 2.1e-9 Calcium levels; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg02976543 chr2:239197607 PER2 0.52 6.55 0.34 2.2e-10 Thyroid stimulating hormone; CRC cis rs7945705 0.719 rs2012680 chr11:8996059 G/A cg14711859 chr11:8959438 ASCL3 0.38 6.43 0.33 4.38e-10 Hemoglobin concentration; CRC cis rs7512552 0.839 rs1260459 chr1:150348253 T/G cg15654264 chr1:150340011 RPRD2 0.58 8.56 0.43 4.48e-16 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); CRC trans rs7829975 0.540 rs2976909 chr8:8346690 C/T cg16141378 chr3:129829833 LOC729375 0.56 8.17 0.41 6.69e-15 Mood instability; CRC trans rs1005277 0.579 rs2505197 chr10:38393310 T/C cg23533926 chr12:111358616 MYL2 -0.52 -7.84 -0.4 6.17e-14 Extrinsic epigenetic age acceleration; CRC cis rs10540 1.000 rs12801271 chr11:508720 C/T cg03352830 chr11:487213 PTDSS2 0.65 7.42 0.38 1.03e-12 Body mass index; CRC cis rs12477438 1.000 rs6732980 chr2:99921613 A/G cg14399236 chr2:99771627 LIPT1;TSGA10 -0.72 -9.02 -0.45 1.64e-17 Chronic sinus infection; CRC cis rs7945718 0.967 rs7931147 chr11:12748884 C/A cg25843174 chr11:12811716 TEAD1 0.46 8.83 0.44 6.25e-17 Educational attainment (years of education); CRC cis rs10791097 0.547 rs11222371 chr11:130745719 C/T cg12179176 chr11:130786555 SNX19 0.78 12.81 0.58 9.18e-31 Autism spectrum disorder or schizophrenia;Schizophrenia; CRC cis rs4423214 0.879 rs1790345 chr11:71145941 G/A cg05163923 chr11:71159392 DHCR7 -0.64 -7.9 -0.4 4.22e-14 Vitamin D levels; CRC cis rs853679 0.517 rs9380062 chr6:28137569 G/A cg03623178 chr6:28175578 NA 0.98 12.66 0.57 3.31e-30 Depression; CRC cis rs4638749 0.677 rs10208945 chr2:108838593 G/C cg25838818 chr2:108905173 SULT1C2 -0.33 -5.61 -0.3 4.35e-8 Blood pressure; CRC cis rs477895 0.713 rs11607165 chr11:63963947 T/G cg23719950 chr11:63933701 MACROD1 -0.67 -8.63 -0.43 2.76e-16 Mean platelet volume; CRC cis rs2739330 0.731 rs4822450 chr22:24242887 C/T cg24846343 chr22:24311635 DDTL 0.73 11.87 0.55 2.62e-27 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs4728302 0.869 rs13231079 chr7:133604373 C/G cg10665199 chr7:133106180 EXOC4 0.38 5.66 0.3 3.32e-8 Intelligence;Intelligence (multi-trait analysis); CRC cis rs12701220 0.553 rs9639882 chr7:1133731 G/A cg26240231 chr7:1148101 C7orf50 -0.41 -5.96 -0.31 6.66e-9 Bronchopulmonary dysplasia; CRC cis rs6502050 0.835 rs4789732 chr17:80131382 A/G cg22110888 chr17:80059540 CCDC57 0.4 6.43 0.33 4.37e-10 Life satisfaction; CRC trans rs5756813 0.661 rs2246503 chr22:38204540 C/A cg19894588 chr14:64061835 NA -0.62 -8.41 -0.42 1.3e-15 Optic cup area;Vertical cup-disc ratio; CRC trans rs6598955 0.671 rs17163746 chr1:26564230 C/A cg07461501 chr17:79650226 HGS;ARL16 -0.51 -6.03 -0.32 4.29e-9 Obesity-related traits; CRC cis rs4908768 0.501 rs11121194 chr1:8569906 C/T cg20416874 chr1:8611966 RERE -0.45 -6.45 -0.33 4.03e-10 Neuroticism (multi-trait analysis);Subjective well-being (multi-trait analysis); CRC cis rs6424115 0.830 rs3003335 chr1:24200052 A/G cg09473613 chr1:24152604 HMGCL 0.35 5.75 0.3 1.99e-8 Immature fraction of reticulocytes; CRC cis rs10193935 1.000 rs10171023 chr2:42407093 G/C cg27598129 chr2:42591480 NA -0.67 -7.81 -0.4 7.86e-14 Colonoscopy-negative controls vs population controls; CRC cis rs2795502 0.630 rs4948698 chr10:43539459 A/G cg08461752 chr10:43522343 NA 0.69 6.75 0.35 6.89e-11 Blood protein levels; CRC cis rs10089 1.000 rs17164310 chr5:127493679 A/G cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.72 9.62 0.47 1.77e-19 Ileal carcinoids; CRC cis rs9584850 0.574 rs17471079 chr13:99168721 C/T cg07423050 chr13:99094983 FARP1 0.48 5.78 0.3 1.73e-8 Neuroticism; CRC cis rs4481887 0.927 rs6587444 chr1:248438452 C/T cg00666640 chr1:248458726 OR2T12 -0.53 -9.5 -0.46 4.4e-19 Common traits (Other); CRC cis rs57221529 0.766 rs12521988 chr5:556421 C/T cg14541582 chr5:601475 NA -0.33 -6.6 -0.34 1.61e-10 Lung disease severity in cystic fibrosis; CRC cis rs1862618 0.853 rs3099459 chr5:56137170 G/C cg20203395 chr5:56204925 C5orf35 -0.71 -8.49 -0.42 6.99e-16 Initial pursuit acceleration; CRC cis rs1448094 0.512 rs11117060 chr12:86250788 G/T cg19622623 chr12:86230825 RASSF9 0.41 6.76 0.35 6.18e-11 Major depressive disorder; CRC cis rs11583043 1.000 rs35445887 chr1:101523639 C/T cg16556008 chr1:101360663 SLC30A7;EXTL2 0.46 5.83 0.31 1.32e-8 Ulcerative colitis;Inflammatory bowel disease; CRC cis rs12701220 0.894 rs12701406 chr7:1050283 G/A cg02733842 chr7:1102375 C7orf50 -0.83 -9.96 -0.48 1.34e-20 Bronchopulmonary dysplasia; CRC cis rs3126085 0.935 rs10888475 chr1:152226012 C/T cg09127314 chr1:152161683 NA 0.52 6.8 0.35 5.05e-11 Atopic dermatitis; CRC cis rs9649213 0.593 rs3801263 chr7:97965016 A/G cg24562669 chr7:97807699 LMTK2 0.43 7.2 0.37 4.11e-12 Prostate cancer (SNP x SNP interaction); CRC cis rs733592 1.000 rs733592 chr12:48429776 C/T cg21466736 chr12:48725269 NA 0.46 7.35 0.38 1.62e-12 Plateletcrit; CRC cis rs1552244 0.935 rs35515831 chr3:10071362 G/A cg18598329 chr3:10140678 FANCD2;C3orf24 -0.89 -12.28 -0.56 8.67e-29 Alzheimer's disease; CRC trans rs6550704 0.687 rs9865314 chr3:22634337 A/G cg15798279 chr7:6523691 KDELR2 -0.42 -6.3 -0.33 9.78e-10 Daytime sleep phenotypes; CRC cis rs1865760 0.786 rs1436308 chr6:25939567 T/G cg16482183 chr6:26056742 HIST1H1C 0.53 7.44 0.38 8.68e-13 Height; CRC cis rs274567 0.501 rs2631368 chr5:131705297 T/G cg12564285 chr5:131593104 PDLIM4 -0.47 -8.04 -0.41 1.62e-14 Blood metabolite levels; CRC cis rs13118159 0.934 rs4974608 chr4:1356780 C/T cg19318889 chr4:1322082 MAEA 0.45 6.73 0.35 7.63e-11 Longevity; CRC cis rs13108904 0.840 rs13106092 chr4:1257290 T/A cg16405210 chr4:1374714 KIAA1530 -0.42 -5.85 -0.31 1.2e-8 Obesity-related traits; CRC cis rs10486722 0.603 rs10486721 chr7:41784860 G/A cg22138096 chr7:41772439 LOC285954 0.37 5.63 0.3 3.87e-8 Pit-and-Fissure caries; CRC cis rs4481887 0.772 rs4916127 chr1:248466615 A/G cg13385794 chr1:248469461 NA 0.39 6.98 0.36 1.62e-11 Common traits (Other); CRC cis rs7937682 1.000 rs11213980 chr11:111562692 A/T cg19812747 chr11:111475976 SIK2 0.52 8.16 0.41 7.39e-15 Primary sclerosing cholangitis; CRC cis rs6087990 0.871 rs4911252 chr20:31330115 A/G cg13636640 chr20:31349939 DNMT3B -0.87 -18.15 -0.71 1.72e-51 Ulcerative colitis; CRC cis rs2625529 0.526 rs8031386 chr15:72508799 C/A cg16672083 chr15:72433130 SENP8 -0.4 -5.96 -0.31 6.52e-9 Red blood cell count; CRC cis rs1577917 0.916 rs12206726 chr6:86499716 C/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.52 -6.9 -0.36 2.74e-11 Response to antipsychotic treatment; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg21046078 chr11:28129852 METT5D1;KIF18A 0.42 6.02 0.31 4.64e-9 Response to antipsychotic treatment; CRC cis rs897984 0.542 rs7294 chr16:31102321 A/G cg02466173 chr16:30829666 NA 0.57 8.75 0.43 1.14e-16 Dementia with Lewy bodies; CRC cis rs4588572 0.643 rs10942857 chr5:77760241 A/G cg11547950 chr5:77652471 NA -0.53 -7.13 -0.37 6.21e-12 Triglycerides; CRC cis rs1506636 0.886 rs6945841 chr7:123266094 G/A cg03229431 chr7:123269106 ASB15 -0.83 -13.57 -0.6 1.3e-33 Plateletcrit;Platelet count; CRC cis rs7193541 0.694 rs8061942 chr16:74691362 C/T cg01733217 chr16:74700730 RFWD3 1.05 21.6 0.77 4.95e-65 Multiple myeloma; CRC cis rs9929218 1.000 rs11865026 chr16:68774283 A/G cg02972257 chr16:68554789 NA 0.44 5.65 0.3 3.54e-8 Colorectal cancer; CRC cis rs908922 0.676 rs1856120 chr1:152512441 G/A cg09873164 chr1:152488093 CRCT1 0.38 6.4 0.33 5.37e-10 Hair morphology; CRC cis rs1023500 0.573 rs1807494 chr22:42474138 C/G cg11915388 chr22:42470451 FAM109B 0.43 6.53 0.34 2.44e-10 Schizophrenia; CRC cis rs68170813 0.559 rs12537730 chr7:106844281 T/C cg02696742 chr7:106810147 HBP1 -0.62 -6.82 -0.35 4.33e-11 Coronary artery disease; CRC cis rs4900538 0.821 rs2009575 chr14:102820787 C/T cg01761236 chr14:102990251 NA -0.28 -5.69 -0.3 2.8e-8 Mean corpuscular volume;Mean corpuscular hemoglobin; CRC cis rs9733 0.596 rs7549795 chr1:150656873 G/A cg17724175 chr1:150552817 MCL1 0.58 9.33 0.46 1.59e-18 Tonsillectomy; CRC trans rs2727020 0.729 rs34647977 chr11:49195543 G/A cg11707556 chr5:10655725 ANKRD33B -0.35 -6.45 -0.34 4.01e-10 Coronary artery disease; CRC cis rs3796352 1.000 rs11718834 chr3:52963668 A/C cg07884673 chr3:53033167 SFMBT1 0.66 5.86 0.31 1.1e-8 Immune reponse to smallpox (secreted IL-2); CRC cis rs875971 0.545 rs313830 chr7:65551931 T/C cg03233332 chr7:66118400 NA 0.46 6.22 0.32 1.51e-9 Aortic root size; CRC cis rs6783573 0.683 rs3806702 chr3:46617502 T/C cg21489266 chr3:46619131 LRRC2;TDGF1 -0.42 -6.05 -0.32 3.95e-9 Cerebrospinal fluid biomarker levels; CRC cis rs12188164 0.965 rs11739543 chr5:443676 G/A cg17553881 chr5:443987 EXOC3;C5orf55 -0.37 -7.81 -0.4 7.64e-14 Cystic fibrosis severity; CRC cis rs16975963 0.644 rs73031321 chr19:38040858 C/T cg15135657 chr19:38346511 NA -0.43 -6.04 -0.32 4.15e-9 Longevity; CRC cis rs6963495 0.818 rs55922564 chr7:105155890 G/A cg02135003 chr7:105160482 PUS7 -0.9 -12.2 -0.56 1.71e-28 Bipolar disorder (body mass index interaction); CRC trans rs2303319 0.504 rs13417851 chr2:162559919 T/G cg27342122 chr8:133787442 PHF20L1 -0.72 -6.4 -0.33 5.33e-10 Cognitive function; CRC cis rs6662572 0.774 rs6696284 chr1:46571684 C/A cg08644498 chr1:46502608 NA 0.43 7.07 0.36 9.5e-12 Blood protein levels; CRC cis rs8062405 0.929 rs11864750 chr16:28875204 A/T cg08761264 chr16:28874980 SH2B1 -0.44 -5.83 -0.31 1.33e-8 Cognitive ability (multi-trait analysis);Cognitive ability; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg22659014 chr13:30169727 SLC7A1 0.42 6.09 0.32 3.23e-9 Intelligence (multi-trait analysis); CRC cis rs2032447 0.898 rs807205 chr6:26075035 C/G cg27635394 chr6:26043820 HIST1H2BB 0.4 5.88 0.31 1.03e-8 Intelligence (multi-trait analysis); CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg14744768 chr7:116312291 MET 0.46 6.48 0.34 3.31e-10 Anxiety disorder; CRC cis rs6582630 0.502 rs8186661 chr12:38380781 G/A cg13010199 chr12:38710504 ALG10B 0.45 5.76 0.3 1.89e-8 Drug-induced liver injury (flucloxacillin); CRC cis rs172166 0.694 rs188105 chr6:28071393 C/T cg25164649 chr6:28176230 NA 0.62 8.85 0.44 5.46e-17 Cardiac Troponin-T levels; CRC cis rs12477438 0.520 rs6542864 chr2:99725223 A/G cg26064155 chr2:99771622 LIPT1;TSGA10 0.87 15.85 0.66 1.99e-42 Chronic sinus infection; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg04116494 chr14:76618702 C14orf118 0.47 6.66 0.34 1.17e-10 Response to antipsychotic treatment; CRC cis rs4481887 0.741 rs7540715 chr1:248544206 C/T cg26353448 chr1:248524236 OR2T4 -0.32 -6.17 -0.32 2.02e-9 Common traits (Other); CRC cis rs1448094 0.512 rs7309500 chr12:86249647 C/T cg00310523 chr12:86230176 RASSF9 0.35 5.93 0.31 7.63e-9 Major depressive disorder; CRC trans rs2055729 0.645 rs12543996 chr8:9742666 C/T cg08975724 chr8:8085496 FLJ10661 -0.47 -6.01 -0.31 4.83e-9 Multiple myeloma (hyperdiploidy); CRC cis rs9611565 0.659 rs56364401 chr22:41951243 T/G cg03806693 chr22:41940476 POLR3H -1.16 -16.06 -0.66 3.02e-43 Vitiligo; CRC cis rs10832963 1.000 rs7943121 chr11:18656062 G/C cg09201001 chr11:18656081 SPTY2D1 0.79 12.29 0.56 7.87e-29 Breast cancer; CRC cis rs12681288 0.963 rs7822955 chr8:1029090 C/T cg15309053 chr8:964076 NA -0.34 -5.79 -0.3 1.64e-8 Schizophrenia; CRC cis rs853679 0.546 rs200950 chr6:27835772 A/G cg03623178 chr6:28175578 NA 0.78 6.65 0.34 1.22e-10 Depression; CRC trans rs2727020 0.576 rs1814175 chr11:49559172 T/C cg15704280 chr7:45808275 SEPT13 -0.94 -17.49 -0.69 6.64e-49 Coronary artery disease; CRC cis rs3771570 1.000 rs4346380 chr2:242263223 G/A cg21155796 chr2:242212141 HDLBP 0.65 7.0 0.36 1.45e-11 Prostate cancer; CRC cis rs34375054 0.526 rs4412800 chr12:125674742 C/T cg02766259 chr12:125626809 AACS 0.46 7.81 0.4 7.66e-14 Post bronchodilator FEV1/FVC ratio; CRC trans rs2303319 0.504 rs56100249 chr2:162415157 T/C cg11326919 chr17:43324904 LOC100133991 -0.67 -5.98 -0.31 5.88e-9 Cognitive function; CRC cis rs4664293 0.625 rs7564585 chr2:160632093 G/A cg08347373 chr2:160653686 CD302 0.43 7.42 0.38 1.03e-12 Monocyte percentage of white cells; CRC trans rs7615952 0.512 rs2979334 chr3:125358824 G/A cg00769240 chr8:12517080 NA -0.74 -10.23 -0.49 1.64e-21 Blood pressure (smoking interaction); CRC trans rs2303319 0.504 rs56274002 chr2:162536715 A/T cg12500891 chr11:57225987 NA -0.67 -6.03 -0.32 4.51e-9 Cognitive function; CRC cis rs7264396 0.563 rs2425132 chr20:34338390 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.47 -7.06 -0.36 9.83e-12 Total cholesterol levels; CRC cis rs28386778 0.863 rs4968661 chr17:61796306 A/G cg06873352 chr17:61820015 STRADA 0.79 15.19 0.64 7.37e-40 Prudent dietary pattern; CRC cis rs10504229 0.861 rs6990796 chr8:58183097 G/C cg02290350 chr8:58132656 NA -0.42 -5.96 -0.31 6.62e-9 Developmental language disorder (linguistic errors); CRC cis rs868036 1.000 rs7168156 chr15:68102933 T/C cg05925327 chr15:68127851 NA -0.3 -5.87 -0.31 1.04e-8 Restless legs syndrome; CRC cis rs950169 1.000 rs35658069 chr15:84780146 C/T cg11189052 chr15:85197271 WDR73 0.61 9.04 0.45 1.35e-17 Schizophrenia; CRC cis rs7927771 0.524 rs10838758 chr11:47771476 T/C cg20307385 chr11:47447363 PSMC3 0.46 6.59 0.34 1.73e-10 Subjective well-being; CRC cis rs78545713 0.536 rs11755618 chr6:26215802 C/T cg01420254 chr6:26195488 NA -0.67 -5.82 -0.31 1.41e-8 Iron status biomarkers (total iron binding capacity); CRC cis rs10206020 0.921 rs10177509 chr2:1568536 T/C cg12573674 chr2:1569213 NA -0.83 -11.17 -0.52 9e-25 IgG glycosylation; CRC cis rs9527 1.000 rs12416687 chr10:104629011 T/C cg04362960 chr10:104952993 NT5C2 0.66 8.06 0.41 1.4e-14 Arsenic metabolism; CRC cis rs116095464 0.867 rs7726582 chr5:215349 C/G cg22857025 chr5:266934 NA -1.19 -15.94 -0.66 8.54e-43 Breast cancer; CRC cis rs7772486 0.875 rs6934467 chr6:146410529 G/T cg13319975 chr6:146136371 FBXO30 -0.4 -5.96 -0.31 6.38e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs9522267 0.502 rs9515450 chr13:112234262 T/C cg10483660 chr13:112241077 NA -0.48 -9.02 -0.45 1.6e-17 Hepatitis; CRC cis rs6500602 0.701 rs11643057 chr16:4544505 C/T cg06139259 chr16:4526053 HMOX2;NMRAL1 0.43 5.91 0.31 8.43e-9 Schizophrenia; CRC cis rs13315871 0.929 rs7628038 chr3:58313813 T/C cg20936604 chr3:58311152 NA -0.76 -7.98 -0.4 2.4e-14 Cholesterol, total; CRC cis rs10504229 0.775 rs17805026 chr8:58160637 A/C cg20607798 chr8:58055168 NA 0.46 5.69 0.3 2.79e-8 Developmental language disorder (linguistic errors); CRC cis rs600231 0.598 rs2508712 chr11:65232261 C/G cg17120908 chr11:65337727 SSSCA1 -0.54 -8.08 -0.41 1.22e-14 Bone mineral density; CRC trans rs7726839 0.540 rs4957083 chr5:659343 T/C cg11887960 chr12:57824829 NA 0.64 7.18 0.37 4.66e-12 Obesity-related traits; CRC cis rs950776 0.518 rs4243083 chr15:78833830 C/G cg06917634 chr15:78832804 PSMA4 -0.68 -10.94 -0.52 5.85e-24 Sudden cardiac arrest; CRC cis rs4481887 0.927 rs4578248 chr1:248434069 G/A cg13385794 chr1:248469461 NA 0.41 7.46 0.38 7.75e-13 Common traits (Other); CRC trans rs4650994 0.524 rs2476558 chr1:178580953 C/T cg05059571 chr16:84539110 KIAA1609 0.59 8.01 0.4 2e-14 HDL cholesterol levels;HDL cholesterol; CRC cis rs2120019 1.000 rs1867146 chr15:75354971 C/G cg17294928 chr15:75287854 SCAMP5 -0.79 -11.46 -0.53 8.45e-26 Blood trace element (Zn levels); CRC cis rs17401966 1.000 rs12132635 chr1:10430479 G/A cg19773385 chr1:10388646 KIF1B -0.56 -7.55 -0.38 4.46e-13 Hepatocellular carcinoma; CRC cis rs951366 0.617 rs823074 chr1:205774839 T/C cg14893161 chr1:205819251 PM20D1 1.05 20.17 0.74 1.78e-59 Menarche (age at onset); CRC cis rs1881797 1.000 rs66845073 chr1:247688010 C/T cg18198730 chr1:247681584 NA 0.54 8.41 0.42 1.25e-15 Acute lymphoblastic leukemia (childhood); CRC cis rs4727027 0.901 rs1534197 chr7:148771970 T/C cg12479418 chr7:148823350 ZNF425;ZNF398 0.46 6.25 0.33 1.24e-9 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg11792075 chr6:53412972 NA 0.45 6.4 0.33 5.26e-10 Anxiety disorder; CRC cis rs10504229 1.000 rs113379801 chr8:58173686 C/G cg05313129 chr8:58192883 C8orf71 -0.46 -7.07 -0.36 9.56e-12 Developmental language disorder (linguistic errors); CRC cis rs7552404 0.924 rs67757078 chr1:76169456 G/A cg10523679 chr1:76189770 ACADM 0.93 14.1 0.61 1.23e-35 Blood metabolite levels;Acylcarnitine levels; CRC cis rs7677751 0.806 rs17084051 chr4:55087581 C/A cg13615338 chr4:55094005 PDGFRA 0.42 6.19 0.32 1.79e-9 Corneal astigmatism; CRC cis rs1949733 0.585 rs2631768 chr4:8473050 A/G cg13073564 chr4:8508604 NA 0.44 6.76 0.35 6.29e-11 Response to antineoplastic agents; CRC cis rs769267 0.930 rs3752151 chr19:19616026 T/C cg03709012 chr19:19516395 GATAD2A 0.72 11.17 0.52 8.58e-25 Tonsillectomy; CRC trans rs6601327 0.585 rs1394 chr8:9511654 G/A cg06636001 chr8:8085503 FLJ10661 -0.5 -7.49 -0.38 6.5e-13 Multiple myeloma (hyperdiploidy); CRC cis rs62458065 0.850 rs62458100 chr7:32473142 C/G cg20159608 chr7:32802032 NA -0.55 -6.56 -0.34 2.09e-10 Metabolite levels (HVA/MHPG ratio); CRC cis rs9341808 0.754 rs6907729 chr6:81004922 A/T cg08355045 chr6:80787529 NA -0.37 -5.94 -0.31 7.35e-9 Sitting height ratio; CRC cis rs13108904 0.870 rs12506095 chr4:1262233 T/C cg02018176 chr4:1364513 KIAA1530 0.45 7.43 0.38 9.46e-13 Obesity-related traits; CRC cis rs1152591 0.543 rs1152594 chr14:64675044 C/T cg21174375 chr14:64681225 SYNE2 -0.39 -6.5 -0.34 2.96e-10 Atrial fibrillation; CRC cis rs1448094 0.511 rs17279261 chr12:86162714 C/T cg18827107 chr12:86230957 RASSF9 -0.4 -5.92 -0.31 8.1e-9 Major depressive disorder; CRC cis rs9443645 0.527 rs9359362 chr6:79723756 T/C cg09184832 chr6:79620586 NA -0.45 -7.71 -0.39 1.52e-13 Intelligence (multi-trait analysis); CRC cis rs9341808 0.754 rs978814 chr6:80959912 G/T cg08355045 chr6:80787529 NA 0.44 7.01 0.36 1.39e-11 Sitting height ratio; CRC cis rs9612 1.000 rs3786954 chr19:44272346 A/G cg08581076 chr19:44259116 C19orf61 0.48 6.28 0.33 1.05e-9 Exhaled nitric oxide output; CRC cis rs727505 1.000 rs6943653 chr7:124512249 G/A cg23710748 chr7:124431027 NA -0.8 -14.18 -0.62 6.24e-36 Lewy body disease; CRC cis rs2976388 0.533 rs12543368 chr8:143819450 T/C cg15511327 chr8:143859410 LYNX1 -0.38 -6.08 -0.32 3.34e-9 Urinary tract infection frequency; CRC cis rs7666738 0.830 rs13110410 chr4:98920018 T/C cg05340658 chr4:99064831 C4orf37 0.6 9.23 0.45 3.31e-18 Colonoscopy-negative controls vs population controls; CRC cis rs3820068 0.532 rs74057713 chr1:15944620 G/C cg13390004 chr1:15929781 NA 0.48 6.93 0.36 2.29e-11 Systolic blood pressure; CRC cis rs1552244 0.882 rs13077641 chr3:10022935 G/A cg02579736 chr3:10068473 FANCD2;CIDECP 0.93 11.94 0.55 1.55e-27 Alzheimer's disease; CRC cis rs9400271 0.632 rs9386784 chr6:109591208 C/A cg01475377 chr6:109611718 NA -0.35 -6.07 -0.32 3.56e-9 Sum neutrophil eosinophil counts;Sum basophil neutrophil counts;White blood cell count;Neutrophil count;Myeloid white cell count;Granulocyte count; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg20024234 chr21:43431083 ZNF295 0.38 6.2 0.32 1.66e-9 Intelligence (multi-trait analysis); CRC cis rs10504229 1.000 rs17805326 chr8:58169533 A/C cg02290350 chr8:58132656 NA -0.43 -6.11 -0.32 2.78e-9 Developmental language disorder (linguistic errors); CRC cis rs208515 0.525 rs10944859 chr6:66665197 A/G cg07460842 chr6:66804631 NA 0.94 11.82 0.55 4.02e-27 Exhaled nitric oxide levels; CRC cis rs12476592 0.602 rs187801 chr2:63867446 A/C cg10828910 chr2:63850056 LOC388955 -0.49 -6.1 -0.32 2.9e-9 Childhood ear infection; CRC cis rs7809950 0.678 rs17153981 chr7:106922106 A/G cg23024343 chr7:107201750 COG5 -0.74 -10.29 -0.49 1.05e-21 Coronary artery disease; CRC cis rs9463078 0.526 rs1159131 chr6:44972209 T/C cg25276700 chr6:44698697 NA 0.25 6.23 0.33 1.39e-9 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; CRC cis rs2251381 0.750 rs2251087 chr21:30527999 C/T cg08807101 chr21:30365312 RNF160 0.66 9.92 0.48 1.79e-20 Selective IgA deficiency; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg04232466 chr8:21988724 HR 0.53 7.79 0.39 8.68e-14 Response to antipsychotic treatment; CRC cis rs9660992 0.573 rs7531256 chr1:205191202 T/G cg00857998 chr1:205179979 DSTYK 0.43 5.78 0.3 1.76e-8 Mean corpuscular volume;Mean platelet volume; CRC cis rs769267 0.930 rs6511038 chr19:19607564 A/C cg02546618 chr19:19431379 KIAA0892;SF4 0.45 6.13 0.32 2.57e-9 Tonsillectomy; CRC cis rs1448094 0.511 rs61930590 chr12:86159959 T/A cg00310523 chr12:86230176 RASSF9 0.38 6.09 0.32 3.11e-9 Major depressive disorder; CRC trans rs637571 0.654 rs1058068 chr11:65667796 G/A cg17712092 chr4:129076599 LARP1B 0.96 18.28 0.71 5.22e-52 Eosinophil percentage of white cells; CRC cis rs1046896 0.594 rs4075209 chr17:80800027 G/T cg17346650 chr17:80929145 B3GNTL1 0.49 7.16 0.37 5.18e-12 Glycated hemoglobin levels; CRC cis rs67478160 0.619 rs55824307 chr14:104271207 C/T cg08213375 chr14:104286397 PPP1R13B 0.63 12.91 0.58 4.04e-31 Schizophrenia; CRC cis rs3087591 0.920 rs11080150 chr17:29629326 A/G cg24425628 chr17:29625626 OMG;NF1 -0.79 -14.6 -0.63 1.43e-37 Hip circumference; CRC cis rs950169 0.922 rs4338765 chr15:84916836 G/T cg17507749 chr15:85114479 UBE2QP1 0.75 10.92 0.52 6.81e-24 Schizophrenia; CRC cis rs597539 0.652 rs488363 chr11:68658298 C/G cg04772025 chr11:68637568 NA 0.48 7.36 0.38 1.51e-12 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs6543140 0.929 rs7602207 chr2:103032366 C/G cg03938978 chr2:103052716 IL18RAP 0.46 7.22 0.37 3.7e-12 Blood protein levels; CRC cis rs2279817 0.955 rs2270977 chr1:18023509 T/C cg21791023 chr1:18019539 ARHGEF10L 0.52 6.42 0.33 4.67e-10 Neuroticism; CRC cis rs2243480 1.000 rs313807 chr7:65499481 C/T cg18252515 chr7:66147081 NA -1.1 -12.34 -0.56 5.31e-29 Diabetic kidney disease; CRC cis rs9611565 0.659 rs11090049 chr22:41915329 C/T cg06634786 chr22:41940651 POLR3H -0.7 -7.85 -0.4 6.12e-14 Vitiligo; CRC trans rs61931739 0.500 rs7296061 chr12:34435009 A/G cg26384229 chr12:38710491 ALG10B -0.68 -9.04 -0.45 1.41e-17 Morning vs. evening chronotype; CRC cis rs1552244 0.626 rs2886396 chr3:10037670 C/T cg18598329 chr3:10140678 FANCD2;C3orf24 -0.81 -10.69 -0.51 4.35e-23 Alzheimer's disease; CRC trans rs10982213 0.830 rs2274163 chr9:117188714 C/T cg17676237 chr17:17400340 RASD1 0.38 6.03 0.32 4.43e-9 Interleukin-6 levels; CRC cis rs2795502 1.000 rs2473119 chr10:43339038 A/T cg27426351 chr10:43362370 NA -0.6 -7.08 -0.36 8.94e-12 Blood protein levels; CRC cis rs950169 0.512 rs4374136 chr15:84645007 C/G cg24253500 chr15:84953950 NA 0.39 5.74 0.3 2.15e-8 Schizophrenia; CRC cis rs4819052 0.851 rs2236445 chr21:46678453 T/C cg02159808 chr21:46707872 POFUT2;LOC642852 0.52 6.81 0.35 4.7e-11 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs17401966 1.000 rs11121533 chr1:10292888 G/C cg19773385 chr1:10388646 KIF1B -0.56 -7.86 -0.4 5.59e-14 Hepatocellular carcinoma; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg02621907 chr5:93954419 ANKRD32;C5orf36 0.46 5.96 0.31 6.41e-9 Thyroid stimulating hormone; CRC cis rs10128264 0.841 rs2790766 chr10:80960616 A/G cg18737081 chr10:80999807 ZMIZ1 0.34 6.41 0.33 5.03e-10 Response to methotrexate in juvenile idiopathic arthritis; CRC cis rs55788414 0.932 rs2317123 chr16:81182636 A/T cg06400318 chr16:81190750 PKD1L2 -0.6 -6.85 -0.35 3.54e-11 Left ventricular obstructive tract defect (maternal effect); CRC cis rs17376456 0.825 rs10476590 chr5:93244884 A/T cg25358565 chr5:93447407 FAM172A 1.09 10.57 0.5 1.14e-22 Diabetic retinopathy; CRC cis rs875971 0.830 rs1167406 chr7:65556936 G/C cg00343986 chr7:65444356 GUSB -0.44 -6.31 -0.33 9.16e-10 Aortic root size; CRC cis rs1707322 1.000 rs9429186 chr1:46539687 C/T cg03146154 chr1:46216737 IPP -0.51 -6.93 -0.36 2.27e-11 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs877282 0.891 rs11595385 chr10:800539 A/G cg17470449 chr10:769945 NA 0.68 9.06 0.45 1.23e-17 Uric acid levels; CRC cis rs243505 0.965 rs243503 chr7:148436106 G/C cg09806900 chr7:148480153 CUL1 -0.46 -6.57 -0.34 2.02e-10 Inflammatory bowel disease;Crohn's disease; CRC cis rs11650494 0.908 rs73340392 chr17:47358308 G/A cg08112188 chr17:47440006 ZNF652 1.1 10.34 0.5 6.73e-22 Prostate cancer; CRC cis rs7614311 0.636 rs73117041 chr3:63896266 A/T cg22134162 chr3:63841271 THOC7 -0.58 -5.85 -0.31 1.18e-8 Lung function (FVC);Lung function (FEV1); CRC cis rs9733 0.569 rs11588404 chr1:150688529 C/A cg17724175 chr1:150552817 MCL1 0.57 9.12 0.45 7.76e-18 Tonsillectomy; CRC cis rs9868809 1.000 rs2310997 chr3:48678011 G/C cg00383909 chr3:49044727 WDR6 0.74 7.11 0.36 7.28e-12 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; CRC cis rs4713118 0.869 rs9283880 chr6:27715243 A/C cg25164649 chr6:28176230 NA 0.59 8.32 0.42 2.36e-15 Parkinson's disease; CRC cis rs2479724 0.805 rs11756454 chr6:41798578 T/A cg17623882 chr6:41773611 USP49 0.53 8.77 0.44 9.65e-17 Menarche (age at onset); CRC cis rs910187 0.605 rs6124960 chr20:45803866 G/C cg27589058 chr20:45804311 EYA2 -0.44 -8.74 -0.43 1.23e-16 Migraine; CRC cis rs9858542 0.953 rs6766581 chr3:49539401 T/C cg07274523 chr3:49395745 GPX1 0.47 6.4 0.33 5.33e-10 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC trans rs1814175 0.591 rs11040589 chr11:49862449 A/G cg03929089 chr4:120376271 NA -0.91 -15.93 -0.66 9.48e-43 Height; CRC cis rs860295 0.702 rs12039893 chr1:155614815 A/C cg02153340 chr1:155202674 NA -0.56 -6.7 -0.35 9.09e-11 Body mass index; CRC cis rs9457247 0.765 rs9457251 chr6:167426707 T/C cg23791538 chr6:167370224 RNASET2 -0.4 -5.98 -0.31 5.7e-9 Crohn's disease; CRC cis rs6952808 0.929 rs12699483 chr7:1975624 C/G cg00106254 chr7:1943704 MAD1L1 -0.45 -6.23 -0.32 1.43e-9 Bipolar disorder and schizophrenia; CRC cis rs7680126 0.596 rs917826 chr4:10295595 C/G cg11266682 chr4:10021025 SLC2A9 -0.43 -6.54 -0.34 2.4e-10 Urate levels in lean individuals;Urate levels in overweight individuals;Urate levels in obese individuals; CRC cis rs185694 0.948 rs200512 chr13:30906446 C/T cg04551440 chr13:30881194 KATNAL1 -0.61 -6.32 -0.33 8.4e-10 Antineutrophil cytoplasmic antibody-associated vasculitis; CRC cis rs7208859 0.623 rs9891166 chr17:29111902 G/A cg13385521 chr17:29058706 SUZ12P 0.73 8.4 0.42 1.39e-15 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs1552244 0.935 rs28815328 chr3:10062227 G/A cg08888203 chr3:10149979 C3orf24 0.67 9.32 0.46 1.77e-18 Alzheimer's disease; CRC cis rs11628318 0.853 rs28444760 chr14:103041148 A/G cg23461800 chr14:103021989 NA -0.76 -10.32 -0.49 8.41e-22 Platelet count; CRC cis rs8105895 0.935 rs9653157 chr19:22249490 T/C cg02657401 chr19:22469223 NA -0.34 -5.65 -0.3 3.56e-8 Body mass index (change over time); CRC cis rs9814567 0.806 rs9857995 chr3:134316706 C/G cg06109529 chr3:134205091 CEP63;ANAPC13 0.69 10.13 0.49 3.46e-21 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC trans rs11098499 0.954 rs6822679 chr4:120402702 A/C cg25214090 chr10:38739885 LOC399744 0.64 10.34 0.5 7.01e-22 Corneal astigmatism; CRC cis rs9768139 0.733 rs12698208 chr7:158117575 C/T cg24154853 chr7:158122151 PTPRN2 0.63 10.43 0.5 3.49e-22 Calcium levels; CRC cis rs11971779 0.680 rs1133067 chr7:139053069 G/T cg23387468 chr7:139079360 LUC7L2 0.41 7.04 0.36 1.14e-11 Diisocyanate-induced asthma; CRC cis rs2882667 0.690 rs10071381 chr5:138272848 C/T cg09476006 chr5:138032270 NA 0.58 9.96 0.48 1.3e-20 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs7258465 1.000 rs34746918 chr19:18539744 C/T cg01065977 chr19:18549689 ISYNA1 -0.42 -6.32 -0.33 8.55e-10 Breast cancer; CRC cis rs1005277 0.505 rs200910 chr10:38108176 C/T cg00409905 chr10:38381863 ZNF37A -0.62 -10.34 -0.5 7.19e-22 Extrinsic epigenetic age acceleration; CRC cis rs9291683 0.566 rs13115776 chr4:10040189 C/G cg11266682 chr4:10021025 SLC2A9 0.52 10.77 0.51 2.35e-23 Bone mineral density; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg06805064 chr13:52263093 WDFY2 0.46 7.03 0.36 1.17e-11 Liver disease severity in Alagille syndrome; CRC cis rs2243480 0.803 rs403089 chr7:65517723 T/C cg18252515 chr7:66147081 NA -1.19 -13.16 -0.59 4.5e-32 Diabetic kidney disease; CRC cis rs6951245 0.938 rs11764937 chr7:1092074 C/T cg08132940 chr7:1081526 C7orf50 -0.53 -5.61 -0.3 4.27e-8 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs2535633 0.631 rs2710314 chr3:52969128 T/C cg15147215 chr3:52552868 STAB1 0.46 7.78 0.39 9.36e-14 Body mass index; CRC cis rs1005277 0.579 rs2474587 chr10:38420666 C/T cg17219203 chr10:38645113 HSD17B7P2 -0.41 -5.76 -0.3 1.92e-8 Extrinsic epigenetic age acceleration; CRC cis rs7959452 0.535 rs10878953 chr12:69674187 A/G cg14784868 chr12:69753453 YEATS4 0.73 12.22 0.56 1.38e-28 Blood protein levels; CRC trans rs12599106 0.709 rs1501462 chr16:34964515 A/T cg15383120 chr6:291909 DUSP22 -0.59 -8.3 -0.42 2.71e-15 Menopause (age at onset); CRC cis rs7223966 1.000 rs2013288 chr17:61785904 C/T cg23090583 chr17:61904693 PSMC5;FTSJ3 0.51 6.36 0.33 6.91e-10 Hip circumference adjusted for BMI;Body mass index; CRC cis rs807029 0.577 rs750866 chr10:102761458 A/G cg04662943 chr10:102668895 NA 0.61 7.09 0.36 8.22e-12 Ejection fraction in Tripanosoma cruzi seropositivity; CRC cis rs8062405 1.000 rs3888190 chr16:28889486 C/A cg16576597 chr16:28551801 NUPR1 0.48 6.79 0.35 5.22e-11 Cognitive ability (multi-trait analysis);Cognitive ability; CRC cis rs896854 0.714 rs6471503 chr8:95990283 G/A cg09323728 chr8:95962352 TP53INP1 -0.44 -7.18 -0.37 4.67e-12 Type 2 diabetes; CRC cis rs597539 0.652 rs11603827 chr11:68719221 C/T cg06112835 chr11:68658793 MRPL21 0.42 6.69 0.35 9.6e-11 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs77633900 0.614 rs280001 chr15:77003566 C/A cg21673338 chr15:77095150 SCAPER -0.71 -7.04 -0.36 1.11e-11 Non-glioblastoma glioma;Glioma; CRC cis rs6665290 0.545 rs6426584 chr1:227374949 A/T cg10327440 chr1:227177885 CDC42BPA -0.76 -12.36 -0.56 4.3e-29 Myeloid white cell count; CRC cis rs10416265 0.527 rs7508599 chr19:33546512 A/T cg17764715 chr19:33622953 WDR88 0.42 6.15 0.32 2.27e-9 Bone properties (heel); CRC cis rs2549003 0.933 rs3846731 chr5:131814264 T/C cg21138405 chr5:131827807 IRF1 0.57 11.37 0.53 1.67e-25 Asthma (sex interaction); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg09662431 chr10:73975914 ASCC1;C10orf104 0.45 6.5 0.34 2.92e-10 Intelligence (multi-trait analysis); CRC cis rs4930103 0.508 rs217205 chr11:1973205 T/C cg23202291 chr11:1979235 NA -0.57 -8.0 -0.4 2.13e-14 DNA methylation (parent-of-origin);DNA methylation (variation); CRC cis rs3820068 0.581 rs72645864 chr1:15921153 C/T cg13390004 chr1:15929781 NA 0.5 6.88 0.35 3.01e-11 Systolic blood pressure; CRC cis rs7493 0.950 rs7785846 chr7:95033841 C/T cg07404485 chr7:94953653 PON1 -0.45 -6.02 -0.32 4.58e-9 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs12497850 0.931 rs13316620 chr3:49045355 T/C cg20833759 chr3:49053208 WDR6;DALRD3 0.54 9.16 0.45 5.58e-18 Parkinson's disease; CRC cis rs17253792 0.822 rs77415412 chr14:56154146 A/G cg01858014 chr14:56050164 KTN1 -0.87 -7.03 -0.36 1.17e-11 Putamen volume; CRC cis rs7726839 0.574 rs12522955 chr5:639231 C/A cg09021430 chr5:549028 NA -0.73 -8.26 -0.41 3.5e-15 Obesity-related traits; CRC cis rs9303401 0.659 rs17741087 chr17:56550300 C/T cg02118635 chr17:56770003 RAD51C;TEX14 0.77 9.6 0.47 2.14e-19 Cognitive test performance; CRC cis rs929354 0.742 rs62491945 chr7:156955580 G/A cg16102536 chr7:156981717 UBE3C 0.4 6.69 0.35 9.57e-11 Body mass index; CRC cis rs4713118 0.955 rs9380012 chr6:27684654 A/G cg19041857 chr6:27730383 NA -0.42 -5.94 -0.31 7.29e-9 Parkinson's disease; CRC trans rs61931739 0.534 rs11053021 chr12:34111157 C/T cg26384229 chr12:38710491 ALG10B 0.53 6.9 0.36 2.71e-11 Morning vs. evening chronotype; CRC cis rs728616 0.867 rs116994688 chr10:81738137 G/C cg05935833 chr10:81318306 SFTPA2 -0.76 -8.28 -0.42 3.12e-15 Chronic obstructive pulmonary disease-related biomarkers; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg06368369 chr3:148709353 GYG1 0.41 6.25 0.33 1.28e-9 Liver disease severity in Alagille syndrome; CRC cis rs875971 0.789 rs7808013 chr7:66071196 A/G cg00343986 chr7:65444356 GUSB -0.46 -6.27 -0.33 1.16e-9 Aortic root size; CRC cis rs2404602 0.716 rs2164101 chr15:76749117 A/G cg22467129 chr15:76604101 ETFA -0.45 -7.62 -0.39 2.67e-13 Blood metabolite levels; CRC cis rs13191362 1.000 rs13199223 chr6:163001083 T/C cg21926612 chr6:163149169 PACRG;PARK2 0.8 11.25 0.53 4.59e-25 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs9303280 0.806 rs2872507 chr17:38040763 C/T cg17467752 chr17:38218738 THRA -0.42 -6.44 -0.33 4.31e-10 Self-reported allergy; CRC cis rs12497850 0.829 rs12636030 chr3:49182237 A/G cg20833759 chr3:49053208 WDR6;DALRD3 0.45 7.29 0.37 2.32e-12 Parkinson's disease; CRC cis rs1005277 0.579 rs2472181 chr10:38386764 T/C cg17219203 chr10:38645113 HSD17B7P2 -0.41 -5.76 -0.3 1.9e-8 Extrinsic epigenetic age acceleration; CRC cis rs4555082 0.874 rs2816606 chr14:105716034 C/T cg06808227 chr14:105710500 BRF1 -0.64 -9.34 -0.46 1.5e-18 Mean platelet volume;Platelet distribution width; CRC cis rs769267 1.000 rs3764567 chr19:19440066 C/T cg20644253 chr19:19431407 KIAA0892;SF4 -0.43 -5.8 -0.3 1.52e-8 Tonsillectomy; CRC cis rs2243480 0.908 rs313822 chr7:65573939 G/A cg25985355 chr7:65971099 NA -0.49 -5.73 -0.3 2.27e-8 Diabetic kidney disease; CRC cis rs79057730 0.599 rs9458 chr7:825494 A/G cg11064039 chr7:766100 PRKAR1B;HEATR2 -0.67 -7.07 -0.36 9.11e-12 Initial pursuit acceleration; CRC cis rs644799 1.000 rs488246 chr11:95560473 T/C cg03916912 chr11:95522834 CEP57;FAM76B 0.95 18.38 0.71 2.03e-52 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs751728 1.000 rs943477 chr6:33750931 T/C cg25922239 chr6:33757077 LEMD2 0.63 9.58 0.47 2.44e-19 Crohn's disease; CRC cis rs7107174 0.892 rs11237477 chr11:78095069 A/T cg02023728 chr11:77925099 USP35 0.46 7.76 0.39 1.08e-13 Testicular germ cell tumor; CRC cis rs951366 0.903 rs823114 chr1:205719532 G/A cg26354017 chr1:205819088 PM20D1 0.47 7.07 0.36 9.44e-12 Menarche (age at onset); CRC cis rs1018836 0.575 rs17635255 chr8:91518135 A/T cg16814680 chr8:91681699 NA -0.57 -6.87 -0.35 3.16e-11 Ejection fraction in Tripanosoma cruzi seropositivity; CRC cis rs9859260 0.744 rs419059 chr3:195782184 C/T cg12923728 chr3:195709715 SDHAP1 0.48 6.54 0.34 2.35e-10 Mean corpuscular volume; CRC cis rs2230307 0.536 rs6577152 chr1:100434610 A/G cg24955406 chr1:100503596 HIAT1 0.56 6.61 0.34 1.55e-10 Carotid intima media thickness; CRC cis rs847577 0.677 rs1495525 chr7:97826232 G/A cg21770322 chr7:97807741 LMTK2 -0.69 -12.68 -0.57 2.97e-30 Breast cancer; CRC cis rs6495122 0.699 rs1378941 chr15:75080150 C/A cg14664628 chr15:75095509 CSK -0.68 -11.03 -0.52 2.85e-24 Caffeine consumption;Diastolic blood pressure;Coffee consumption; CRC cis rs4927850 1.000 rs7614767 chr3:195753451 C/T cg12923728 chr3:195709715 SDHAP1 -0.71 -10.89 -0.51 8.38e-24 Pancreatic cancer; CRC cis rs4689388 0.929 rs1046320 chr4:6304344 C/T cg25554036 chr4:6271136 WFS1 0.51 8.35 0.42 1.98e-15 Type 2 diabetes and other traits;Type 2 diabetes; CRC cis rs6570726 0.791 rs370654 chr6:145879005 C/G cg05347473 chr6:146136440 FBXO30 0.4 6.1 0.32 2.95e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs6963495 0.818 rs73190151 chr7:105152887 C/T cg02135003 chr7:105160482 PUS7 -0.9 -12.16 -0.56 2.37e-28 Bipolar disorder (body mass index interaction); CRC cis rs2115630 0.755 rs7169629 chr15:85191274 C/G cg11189052 chr15:85197271 WDR73 0.64 10.73 0.51 3.18e-23 P wave terminal force; CRC cis rs9906695 0.846 rs3091317 chr17:32594257 T/C cg12698626 chr17:32581466 CCL2 0.44 6.0 0.31 5.19e-9 Monocyte percentage of white cells; CRC cis rs13064411 0.735 rs722392 chr3:113228294 A/G cg10517650 chr3:113235015 CCDC52 -0.41 -7.07 -0.36 9.15e-12 Response to simvastatin treatment (PCSK9 protein level change); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg03670158 chr17:41323431 NBR1 0.46 6.47 0.34 3.47e-10 Response to antipsychotic treatment; CRC cis rs1003719 0.762 rs34273703 chr21:38475019 A/G cg10648535 chr21:38446584 PIGP;TTC3 0.52 7.41 0.38 1.07e-12 Eye color traits; CRC cis rs2303759 0.507 rs35042238 chr19:49872941 C/T cg22590775 chr19:49891494 CCDC155 0.64 6.38 0.33 5.87e-10 Multiple sclerosis; CRC trans rs9858542 1.000 rs9836291 chr3:49697459 G/A cg21582582 chr3:182698605 DCUN1D1 -0.53 -6.55 -0.34 2.24e-10 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs898097 0.845 rs7213006 chr17:80899928 T/C cg15369054 chr17:80825471 TBCD -0.39 -6.22 -0.32 1.53e-9 Breast cancer; CRC trans rs1814175 0.654 rs1164676 chr11:49324868 T/C cg03929089 chr4:120376271 NA 0.81 12.74 0.57 1.68e-30 Height; CRC cis rs12586317 0.547 rs77780729 chr14:35496176 C/A cg05294307 chr14:35346193 BAZ1A -0.7 -7.53 -0.38 4.9e-13 Psoriasis; CRC cis rs9894429 0.608 rs7406219 chr17:79609410 G/T cg13777783 chr17:79615861 NA -0.3 -5.67 -0.3 3.13e-8 Eye color traits; CRC cis rs853679 0.550 rs1225599 chr6:28165190 C/T cg23161317 chr6:28129485 ZNF389 0.46 6.02 0.31 4.79e-9 Depression; CRC cis rs9814567 1.000 rs9814567 chr3:134218557 C/T cg06109529 chr3:134205091 CEP63;ANAPC13 0.81 11.98 0.55 1.06e-27 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs9660180 0.935 rs9786942 chr1:1759213 A/G cg05132306 chr1:1846340 CALML6 -0.48 -7.32 -0.37 1.9e-12 Body mass index; CRC cis rs16975963 0.843 rs73029180 chr19:38420406 C/T cg15135657 chr19:38346511 NA -0.44 -5.92 -0.31 7.99e-9 Longevity; CRC cis rs2742417 0.935 rs2248991 chr3:45754749 G/A cg04837898 chr3:45731254 SACM1L -0.36 -5.92 -0.31 7.95e-9 Response to anti-depressant treatment in major depressive disorder; CRC cis rs1218582 0.772 rs1976559 chr1:154879788 A/T cg16680214 chr1:154839983 KCNN3 -0.45 -8.95 -0.44 2.64e-17 Prostate cancer; CRC cis rs7193541 0.684 rs9931225 chr16:74699293 T/C cg01733217 chr16:74700730 RFWD3 1.05 22.28 0.78 1.13e-67 Multiple myeloma; CRC cis rs9470366 0.883 rs12199346 chr6:36641546 C/A cg08179530 chr6:36648295 CDKN1A 0.53 6.22 0.32 1.52e-9 QRS duration; CRC cis rs5750830 0.649 rs5750808 chr22:39790987 G/A cg25459000 chr22:39777742 SYNGR1 -0.32 -5.63 -0.3 3.83e-8 Intelligence (multi-trait analysis); CRC trans rs10982213 0.830 rs2274163 chr9:117188714 C/T cg23486179 chr3:49466665 NICN1 0.41 6.44 0.33 4.23e-10 Interleukin-6 levels; CRC cis rs597539 0.652 rs11603827 chr11:68719221 C/T cg21963583 chr11:68658836 MRPL21 0.57 9.96 0.48 1.3e-20 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs1448094 0.510 rs1993806 chr12:86147151 T/C cg00310523 chr12:86230176 RASSF9 -0.36 -5.92 -0.31 8.25e-9 Major depressive disorder; CRC cis rs514406 0.861 rs72637996 chr1:53249618 A/T cg25767906 chr1:53392781 SCP2 0.4 6.53 0.34 2.53e-10 Monocyte count; CRC cis rs2777491 0.574 rs11858812 chr15:41731550 G/A cg18705301 chr15:41695430 NDUFAF1 -1.13 -20.52 -0.75 7.65e-61 Ulcerative colitis; CRC cis rs754466 0.580 rs12357670 chr10:79558180 T/C cg17075019 chr10:79541650 NA -0.97 -18.65 -0.72 1.84e-53 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs728616 0.867 rs61859008 chr10:81831711 C/G cg05935833 chr10:81318306 SFTPA2 -0.55 -6.42 -0.33 4.66e-10 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs736408 0.609 rs13082208 chr3:52781539 T/G cg07507251 chr3:52567010 NT5DC2 0.43 6.02 0.31 4.74e-9 Bipolar disorder; CRC cis rs75804782 0.520 rs34058921 chr2:239318665 C/T cg18131467 chr2:239335373 ASB1 -0.72 -6.24 -0.33 1.32e-9 Morning vs. evening chronotype;Chronotype; CRC cis rs12497850 0.931 rs9682444 chr3:48852639 A/G cg07636037 chr3:49044803 WDR6 1.03 18.15 0.71 1.69e-51 Parkinson's disease; CRC cis rs6684514 0.961 rs10908497 chr1:156274740 G/A cg16558208 chr1:156270281 VHLL 0.57 8.89 0.44 4.08e-17 Mean corpuscular hemoglobin concentration;Glycated hemoglobin levels; CRC cis rs2346177 0.844 rs4953365 chr2:46644946 G/C cg26688816 chr2:46740690 ATP6V1E2 -0.49 -7.11 -0.37 7.11e-12 HDL cholesterol; CRC cis rs7091068 0.566 rs7082701 chr10:95501042 G/T cg20715218 chr10:95462985 C10orf4 0.54 5.71 0.3 2.46e-8 Urinary tract infection frequency; CRC cis rs4481887 0.893 rs10788774 chr1:248471712 T/C cg13385794 chr1:248469461 NA 0.39 6.88 0.35 3.03e-11 Common traits (Other); CRC cis rs9611565 0.512 rs139561 chr22:42195410 C/T cg06481639 chr22:41940642 POLR3H 0.53 5.89 0.31 9.41e-9 Vitiligo; CRC cis rs10876993 0.855 rs10877007 chr12:58100058 T/A cg15848620 chr12:58087721 OS9 -0.64 -8.98 -0.44 2.1e-17 Celiac disease or Rheumatoid arthritis; CRC cis rs2836974 0.863 rs8128026 chr21:40533702 T/C cg06238570 chr21:40685208 BRWD1 0.74 10.4 0.5 4.41e-22 Cognitive function; CRC cis rs7223966 1.000 rs9901112 chr17:61730617 C/G cg23090583 chr17:61904693 PSMC5;FTSJ3 0.48 6.01 0.31 4.79e-9 Hip circumference adjusted for BMI;Body mass index; CRC cis rs10504229 1.000 rs17216648 chr8:58169429 C/T cg02725872 chr8:58115012 NA -0.39 -6.63 -0.34 1.38e-10 Developmental language disorder (linguistic errors); CRC cis rs7819412 0.525 rs10086521 chr8:10783769 A/G cg27411982 chr8:10470053 RP1L1 -0.39 -6.07 -0.32 3.52e-9 Triglycerides; CRC cis rs3741151 1.000 rs75114310 chr11:73042047 C/T cg17517138 chr11:73019481 ARHGEF17 1.12 9.47 0.46 5.76e-19 GIP levels in response to oral glucose tolerance test (120 minutes); CRC cis rs4332037 0.851 rs28728306 chr7:1961814 C/A cg21155852 chr7:2048760 MAD1L1 -0.5 -6.83 -0.35 4.22e-11 Bipolar disorder; CRC cis rs9914988 0.943 rs9890377 chr17:27111111 A/G cg16670446 chr17:27188758 MIR451;MIR144 0.55 8.52 0.43 5.75e-16 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs1448094 0.556 rs17345522 chr12:86169929 T/C cg25456477 chr12:86230367 RASSF9 0.42 7.03 0.36 1.22e-11 Major depressive disorder; CRC cis rs2836974 0.568 rs429955 chr21:40539760 G/A cg11890956 chr21:40555474 PSMG1 0.93 16.72 0.68 7.27e-46 Cognitive function; CRC cis rs425535 0.757 rs164616 chr4:74798566 A/G cg01447579 chr4:74847100 PF4 0.62 5.69 0.3 2.82e-8 Blood protein levels; CRC cis rs6952808 1.000 rs6953693 chr7:1886388 C/G cg20295408 chr7:1910781 MAD1L1 -0.42 -5.99 -0.31 5.61e-9 Bipolar disorder and schizophrenia; CRC cis rs2933343 0.679 rs1091938 chr3:128637025 T/C cg11901034 chr3:128598214 ACAD9 -0.56 -7.81 -0.4 7.72e-14 IgG glycosylation; CRC cis rs7259376 0.936 rs2195965 chr19:22538111 C/T cg02657401 chr19:22469223 NA -0.34 -7.62 -0.39 2.73e-13 Menopause (age at onset); CRC cis rs5750830 0.649 rs5757659 chr22:39812409 A/C cg24399712 chr22:39784796 NA -0.48 -8.66 -0.43 2.22e-16 Intelligence (multi-trait analysis); CRC cis rs7617480 0.648 rs4858800 chr3:48755820 A/G cg07636037 chr3:49044803 WDR6 0.72 8.96 0.44 2.41e-17 Subjective well-being (multi-trait analysis);Menarche (age at onset); CRC cis rs7209700 0.662 rs8080254 chr17:45347892 C/G cg08085267 chr17:45401833 C17orf57 -0.43 -5.88 -0.31 1.01e-8 IgG glycosylation; CRC cis rs7727544 1.000 rs10076701 chr5:131596419 A/G cg02033258 chr5:131593261 PDLIM4 0.38 7.65 0.39 2.23e-13 Blood metabolite levels; CRC cis rs2732480 0.577 rs2732466 chr12:48732459 A/G cg04545296 chr12:48745243 ZNF641 0.36 6.22 0.32 1.52e-9 Hemoglobin concentration;Red blood cell count;Hematocrit; CRC cis rs7916697 0.593 rs7912895 chr10:70021498 A/G cg06988349 chr10:69991859 ATOH7 0.39 7.27 0.37 2.69e-12 Optic disc area; CRC cis rs10089 1.000 rs77086350 chr5:127494431 G/A cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.68 9.14 0.45 6.36e-18 Ileal carcinoids; CRC cis rs9303401 0.659 rs3809724 chr17:57061238 G/A cg02118635 chr17:56770003 RAD51C;TEX14 0.83 9.84 0.48 3.41e-20 Cognitive test performance; CRC cis rs9811920 0.809 rs793464 chr3:99626028 G/A cg07805332 chr3:99536008 MIR548G;C3orf26 -0.39 -6.0 -0.31 5.34e-9 Axial length; CRC cis rs6502050 0.799 rs7212023 chr17:80170354 G/A cg13198984 chr17:80129470 CCDC57 0.48 8.36 0.42 1.84e-15 Life satisfaction; CRC cis rs7615952 0.599 rs2270986 chr3:125701099 T/C cg04553112 chr3:125709451 NA -0.5 -5.7 -0.3 2.61e-8 Blood pressure (smoking interaction); CRC cis rs10791323 0.569 rs10791335 chr11:133739571 A/T cg06766960 chr11:133703094 NA -0.36 -6.5 -0.34 3.03e-10 Childhood ear infection; CRC cis rs4478137 0.931 rs7665672 chr4:164236875 G/A cg06758707 chr4:164254230 NPY1R 0.39 6.01 0.31 4.9e-9 Subjective well-being (multi-trait analysis);Subjective well-being; CRC cis rs4713118 0.866 rs9468217 chr6:27726467 G/A cg15845792 chr6:28175446 NA 0.66 7.8 0.4 8.13e-14 Parkinson's disease; CRC cis rs7605827 0.930 rs7568459 chr2:15691026 C/T cg19274914 chr2:15703543 NA 0.39 5.82 0.31 1.4e-8 Educational attainment (years of education); CRC cis rs2455799 0.519 rs2062821 chr3:15697644 A/T cg16303742 chr3:15540471 COLQ -0.39 -6.15 -0.32 2.29e-9 Mean platelet volume; CRC cis rs7618915 0.547 rs2878726 chr3:52748271 C/G cg05573699 chr3:52720067 GNL3;PBRM1 -0.44 -6.15 -0.32 2.23e-9 Bipolar disorder; CRC cis rs597539 0.652 rs668576 chr11:68668208 A/G cg06028808 chr11:68637592 NA 0.42 6.65 0.34 1.19e-10 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC trans rs12458462 1.000 rs12458462 chr18:77472436 C/A cg09220050 chr20:48770642 TMEM189;TMEM189-UBE2V1 -0.48 -7.03 -0.36 1.23e-11 Monocyte count; CRC cis rs3741151 1.000 rs111882289 chr11:73053714 T/C cg17517138 chr11:73019481 ARHGEF17 1.06 9.16 0.45 5.53e-18 GIP levels in response to oral glucose tolerance test (120 minutes); CRC cis rs9549367 0.789 rs12584981 chr13:113881185 T/C cg18105134 chr13:113819100 PROZ -0.72 -10.82 -0.51 1.47e-23 Platelet distribution width; CRC cis rs992157 0.560 rs6436048 chr2:219109033 C/T cg04731861 chr2:219085781 ARPC2 -0.36 -7.9 -0.4 4.22e-14 Colorectal cancer; CRC cis rs72781680 1.000 rs72781675 chr2:24232092 G/A cg08917208 chr2:24149416 ATAD2B 0.94 9.04 0.45 1.4e-17 Lymphocyte counts; CRC trans rs6951245 1.000 rs2363286 chr7:1091625 A/G cg13565492 chr6:43139072 SRF -0.62 -6.47 -0.34 3.46e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs9302635 0.626 rs34508528 chr16:72215115 C/T cg23815491 chr16:72088622 HP 0.51 6.3 0.33 9.58e-10 Blood protein levels; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg24836583 chr19:19051747 HOMER3 0.43 6.89 0.36 2.84e-11 Liver disease severity in Alagille syndrome; CRC trans rs3733585 0.673 rs4235347 chr4:9951956 C/T cg26043149 chr18:55253948 FECH -0.5 -7.71 -0.39 1.51e-13 Cleft plate (environmental tobacco smoke interaction); CRC cis rs9399137 0.507 rs4520025 chr6:135278619 G/T cg22676075 chr6:135203613 NA 0.61 9.09 0.45 9.44e-18 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; CRC cis rs56283067 0.847 rs1283948 chr6:44691702 C/T cg18551225 chr6:44695536 NA -0.41 -5.9 -0.31 8.9e-9 Total body bone mineral density; CRC cis rs11105298 0.891 rs10858854 chr12:89835728 C/A cg00757033 chr12:89920650 WDR51B 0.39 6.42 0.33 4.88e-10 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; CRC cis rs12477438 0.520 rs13018891 chr2:99755099 C/G cg26064155 chr2:99771622 LIPT1;TSGA10 0.87 15.71 0.65 6.73e-42 Chronic sinus infection; CRC cis rs12477438 0.501 rs6708878 chr2:99801564 G/A cg14399236 chr2:99771627 LIPT1;TSGA10 0.73 12.17 0.56 2.24e-28 Chronic sinus infection; CRC cis rs67311347 1.000 rs897117 chr3:40437294 C/T cg24209194 chr3:40518798 ZNF619 -0.43 -6.64 -0.34 1.27e-10 Renal cell carcinoma; CRC cis rs10946940 0.965 rs4713112 chr6:27516833 G/T cg08798685 chr6:27730294 NA 0.38 5.66 0.3 3.24e-8 Systemic lupus erythematosus; CRC cis rs798554 0.797 rs1182184 chr7:2872446 G/A cg17321639 chr7:2759063 NA -0.53 -7.15 -0.37 5.82e-12 Height; CRC cis rs1707322 1.000 rs4660903 chr1:46457601 A/G cg03146154 chr1:46216737 IPP 0.51 7.15 0.37 5.54e-12 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs5753618 0.561 rs4820963 chr22:31698166 C/T cg22777020 chr22:31556080 RNF185 -0.53 -6.04 -0.32 4.08e-9 Colorectal cancer; CRC cis rs881375 0.967 rs876445 chr9:123677102 A/T cg09419670 chr9:123605666 PSMD5;LOC253039 0.59 8.73 0.43 1.34e-16 Rheumatoid arthritis; CRC cis rs7605378 1.000 rs2346662 chr2:200679158 C/T cg17644776 chr2:200775616 C2orf69 0.41 6.0 0.31 5.35e-9 Osteoporosis; CRC cis rs1559088 0.803 rs10411529 chr19:33616256 A/C cg27124370 chr19:33622961 WDR88 0.41 5.72 0.3 2.39e-8 Bone ultrasound measurement (broadband ultrasound attenuation); CRC cis rs2075165 0.901 rs7522860 chr1:156275281 C/T cg20302342 chr1:156215951 PAQR6 0.35 6.92 0.36 2.37e-11 Tonsillectomy; CRC cis rs11648796 0.757 rs66649828 chr16:766078 A/G cg27144592 chr16:783916 NARFL 0.54 8.7 0.43 1.57e-16 Height; CRC cis rs2228479 0.717 rs1800358 chr16:89809319 T/C cg06558623 chr16:89946397 TCF25 0.84 8.8 0.44 7.89e-17 Skin colour saturation; CRC cis rs362272 0.545 rs2748447 chr4:3337831 G/A cg02993699 chr4:3415135 RGS12 -0.4 -6.53 -0.34 2.55e-10 Serum sulfate level; CRC cis rs9527 0.590 rs10509764 chr10:104776475 G/A cg04362960 chr10:104952993 NT5C2 0.6 8.46 0.42 9.02e-16 Arsenic metabolism; CRC cis rs10504229 1.000 rs72650887 chr8:58177343 G/A cg05313129 chr8:58192883 C8orf71 -0.47 -6.99 -0.36 1.53e-11 Developmental language disorder (linguistic errors); CRC cis rs2115536 0.730 rs4238512 chr15:80183898 A/C cg00225070 chr15:80189496 MTHFS -0.42 -6.48 -0.34 3.43e-10 Eosinophil counts;Eosinophil percentage of white cells;Sum eosinophil basophil counts;Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; CRC cis rs6546550 0.901 rs6736408 chr2:70137774 C/T cg02498382 chr2:70120550 SNRNP27 -0.56 -9.52 -0.46 3.78e-19 Prevalent atrial fibrillation; CRC trans rs66759488 0.739 rs10851451 chr15:47608991 A/G cg08460590 chr17:7495881 FXR2 -0.43 -6.02 -0.31 4.55e-9 Lung cancer; CRC cis rs3768617 0.528 rs10737242 chr1:183098249 A/G ch.1.3577855R chr1:183094577 LAMC1 0.89 15.78 0.66 3.75e-42 Fuchs's corneal dystrophy; CRC cis rs7937682 0.924 rs10891284 chr11:111527737 T/C cg09085632 chr11:111637200 PPP2R1B -1.0 -20.15 -0.74 2.29e-59 Primary sclerosing cholangitis; CRC cis rs801193 0.967 rs1110414 chr7:66205582 A/G cg05627663 chr7:65219948 SNORA22;CCT6P1 0.42 6.12 0.32 2.65e-9 Aortic root size; CRC cis rs10911363 0.592 rs2702205 chr1:183457198 A/G cg09173681 chr1:183549694 NCF2 0.74 10.31 0.49 8.54e-22 Systemic lupus erythematosus; CRC cis rs6952808 0.964 rs6945719 chr7:1932688 G/A cg04267008 chr7:1944627 MAD1L1 -0.83 -12.63 -0.57 4.42e-30 Bipolar disorder and schizophrenia; CRC trans rs747782 0.527 rs12289516 chr11:48234680 G/A cg27395922 chr11:50257633 LOC441601 0.49 6.21 0.32 1.6e-9 Intraocular pressure; CRC cis rs2762353 0.538 rs35670731 chr6:25728235 C/T cg03264133 chr6:25882463 NA 0.73 10.28 0.49 1.13e-21 Blood metabolite levels; CRC cis rs875971 0.862 rs7809814 chr7:65615397 G/A cg12463550 chr7:65579703 CRCP -0.54 -7.54 -0.38 4.47e-13 Aortic root size; CRC cis rs798554 1.000 rs798554 chr7:2759795 C/T cg17321639 chr7:2759063 NA -0.56 -7.76 -0.39 1.06e-13 Height; CRC cis rs11608355 0.515 rs2270361 chr12:109935894 G/C cg05360138 chr12:110035743 NA 0.76 8.5 0.42 6.78e-16 Neuroticism; CRC cis rs765787 0.530 rs2413776 chr15:45544170 A/G cg24006582 chr15:45444508 DUOX1 -0.57 -8.54 -0.43 5.23e-16 Uric acid levels; CRC cis rs8067545 0.611 rs11868116 chr17:20029593 T/C cg13482628 chr17:19912719 NA 0.44 6.95 0.36 2e-11 Schizophrenia; CRC cis rs780094 0.500 rs7570476 chr2:27784658 C/T cg27432699 chr2:27873401 GPN1 0.45 5.87 0.31 1.07e-8 Calcium levels;Fasting blood insulin;Metabolic traits;Triglyceride levels;Fasting plasma glucose;Urate levels in overweight individuals;Urate levels in obese individuals;Uric acid levels;Height;Age-related diseases, mortality and associated endophenotypes;Renal underexcretion gout;Fasting blood glucose (BMI interaction);Urate levels;Gondoic acid (20:1n-9) levels;Fasting blood insulin (BMI interaction);Triglycerides;Plasma omega-3 polyunsaturated fatty acid levels (docosapentaenoic acid);Type 2 diabetes;Nonalcoholic fatty liver disease;Hypertriglyceridemia;C-reactive protein;Age-related disease endophenotypes;LDL cholesterol;Metabolic syndrome;Crohn's disease;Alcohol consumption (drinks per week);Homeostasis model assessment of insulin resistance;Alcohol consumption;Red blood cell count;Fasting blood glucose; CRC trans rs17685 0.672 rs6465011 chr7:75811297 T/C cg19862616 chr7:65841803 NCRNA00174 0.96 16.52 0.67 4.66e-45 Coffee consumption;Coffee consumption (cups per day); CRC cis rs870825 0.616 rs28672716 chr4:185647345 G/A cg04058563 chr4:185651563 MLF1IP 0.72 9.3 0.46 2.04e-18 Blood protein levels; CRC cis rs4332037 0.586 rs62442944 chr7:2015047 T/G cg24505167 chr7:1915268 MAD1L1 -0.45 -6.35 -0.33 6.97e-10 Bipolar disorder; CRC cis rs2204008 0.743 rs2127952 chr12:37995364 G/T cg26384229 chr12:38710491 ALG10B 0.67 9.43 0.46 7.83e-19 Bladder cancer; CRC cis rs6961069 0.722 rs4626520 chr7:80260023 G/A cg04458919 chr7:80252533 CD36 0.34 5.89 0.31 9.42e-9 Platelet count; CRC cis rs17767392 0.681 rs61989208 chr14:71691037 G/C cg13720639 chr14:72061746 SIPA1L1 -0.51 -6.5 -0.34 2.98e-10 Mitral valve prolapse; CRC cis rs1800795 0.652 rs7802307 chr7:22766433 T/A cg26061582 chr7:22766209 IL6 0.55 8.54 0.43 5.2e-16 Cerebrospinal fluid clusterin levels in APOEe4- carriers; CRC cis rs72781680 0.898 rs55657921 chr2:24008091 C/G cg08917208 chr2:24149416 ATAD2B 0.84 8.11 0.41 1e-14 Lymphocyte counts; CRC cis rs6831352 0.693 rs2602875 chr4:100039495 C/G cg12011299 chr4:100065546 ADH4 0.45 8.75 0.43 1.1e-16 Alcohol dependence; CRC cis rs9372498 0.536 rs77435770 chr6:118819467 G/A cg01339444 chr6:118972232 C6orf204 0.53 6.0 0.31 5.22e-9 Diastolic blood pressure; CRC cis rs854765 0.647 rs854790 chr17:18028318 C/G cg24612305 chr17:17875800 TOM1L2;LRRC48 0.7 11.39 0.53 1.45e-25 Total body bone mineral density; CRC cis rs2415984 0.622 rs28487986 chr14:46924435 T/G cg14871534 chr14:47121158 RPL10L -0.43 -6.19 -0.32 1.77e-9 Number of children ever born; CRC cis rs514406 0.505 rs448788 chr1:53161620 A/G cg08859206 chr1:53392774 SCP2 0.4 5.93 0.31 7.78e-9 Monocyte count; CRC cis rs17270561 0.609 rs1165208 chr6:25803904 G/A cg16482183 chr6:26056742 HIST1H1C 0.59 8.08 0.41 1.25e-14 Iron status biomarkers; CRC cis rs9916302 0.904 rs9905432 chr17:37555918 C/A cg07936489 chr17:37558343 FBXL20 0.85 13.38 0.59 6.93e-33 Glomerular filtration rate (creatinine); CRC cis rs3785574 0.962 rs56295011 chr17:61850359 A/G cg06873352 chr17:61820015 STRADA 0.5 8.04 0.41 1.68e-14 Height; CRC cis rs9311474 0.607 rs4234633 chr3:52557038 C/T cg10802521 chr3:52805072 NEK4 -0.51 -7.89 -0.4 4.59e-14 Electroencephalogram traits; CRC cis rs12477438 0.677 rs12475034 chr2:99699464 A/G cg26064155 chr2:99771622 LIPT1;TSGA10 -0.7 -8.65 -0.43 2.37e-16 Chronic sinus infection; CRC cis rs1322639 1.000 rs1322639 chr6:169587103 G/A cg04662567 chr6:169592167 NA 0.46 7.56 0.38 4.03e-13 Pulse pressure; CRC cis rs9287719 0.967 rs715246 chr2:10736355 G/A cg00105475 chr2:10696890 NA 0.45 7.3 0.37 2.19e-12 Prostate cancer; CRC cis rs6121246 0.908 rs17093657 chr20:30428894 G/A cg18721089 chr20:30220636 NA -0.36 -5.82 -0.31 1.39e-8 Mean corpuscular hemoglobin; CRC trans rs7819412 0.806 rs6980856 chr8:10938260 A/G cg08071915 chr8:12219732 FAM66A -0.36 -6.32 -0.33 8.73e-10 Triglycerides; CRC cis rs4713118 0.866 rs2179094 chr6:27741825 T/C cg08798685 chr6:27730294 NA -0.48 -6.78 -0.35 5.61e-11 Parkinson's disease; CRC cis rs12188164 0.686 rs72711365 chr5:416672 G/A cg21972741 chr5:435613 AHRR 0.47 6.46 0.34 3.73e-10 Cystic fibrosis severity; CRC cis rs4713118 0.662 rs9468275 chr6:28026136 G/T cg18032046 chr6:28092343 ZSCAN16 -0.51 -6.46 -0.34 3.86e-10 Parkinson's disease; CRC trans rs7762018 0.769 rs7766146 chr6:170070135 A/T cg06875740 chr19:51307921 C19orf48 -0.66 -6.0 -0.31 5.19e-9 Thiazide-induced adverse metabolic effects in hypertensive patients; CRC cis rs4862750 0.794 rs7672272 chr4:187896774 T/G cg27532560 chr4:187881888 NA -0.56 -10.23 -0.49 1.63e-21 Lobe attachment (rater-scored or self-reported); CRC cis rs6604026 0.922 rs58270016 chr1:93295723 T/C cg17283838 chr1:93427260 FAM69A 0.45 5.68 0.3 2.92e-8 Multiple sclerosis; CRC trans rs11098499 0.954 rs13107475 chr4:120393011 A/T cg25214090 chr10:38739885 LOC399744 0.66 10.6 0.5 8.61e-23 Corneal astigmatism; CRC cis rs6952808 0.723 rs60995052 chr7:2030007 G/C cg02951883 chr7:2050386 MAD1L1 -0.78 -12.8 -0.58 1.04e-30 Bipolar disorder and schizophrenia; CRC cis rs79349575 0.783 rs1994970 chr17:47014127 C/T cg22482690 chr17:47019901 SNF8 -0.52 -8.2 -0.41 5.41e-15 Type 2 diabetes; CRC cis rs8031584 0.872 rs11634761 chr15:31243173 A/C cg14829155 chr15:31115871 NA -0.52 -8.3 -0.42 2.79e-15 Huntington's disease progression; CRC cis rs72945132 0.638 rs11236127 chr11:70241536 G/C cg14191688 chr11:70257035 CTTN 0.52 7.15 0.37 5.49e-12 Coronary artery disease; CRC cis rs9309473 1.000 rs7598419 chr2:73798223 A/G cg20560298 chr2:73613845 ALMS1 -0.52 -5.99 -0.31 5.6e-9 Metabolite levels; CRC cis rs919433 1.000 rs919433 chr2:198166565 G/A cg10820045 chr2:198174542 NA -0.55 -10.34 -0.5 6.7e-22 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC cis rs853679 0.517 rs9368558 chr6:28133306 A/G cg02631126 chr6:28058918 ZSCAN12L1 0.29 5.91 0.31 8.38e-9 Depression; CRC cis rs9733 0.650 rs6698495 chr1:150564476 T/C cg17724175 chr1:150552817 MCL1 -0.51 -8.18 -0.41 6.1e-15 Tonsillectomy; CRC cis rs1218582 0.772 rs4845690 chr1:154886817 C/T cg24250549 chr1:154909240 PMVK -0.65 -11.38 -0.53 1.6e-25 Prostate cancer; CRC cis rs4332037 0.722 rs60346318 chr7:1915824 C/G cg21155852 chr7:2048760 MAD1L1 -0.4 -5.62 -0.3 4.03e-8 Bipolar disorder; CRC cis rs2479724 0.868 rs2249703 chr6:41814760 A/G cg17623882 chr6:41773611 USP49 -0.58 -9.92 -0.48 1.78e-20 Menarche (age at onset); CRC cis rs7107174 1.000 rs1399196 chr11:78071876 A/G cg02023728 chr11:77925099 USP35 0.45 7.99 0.4 2.34e-14 Testicular germ cell tumor; CRC cis rs4629710 0.592 rs13206776 chr6:131576679 T/G cg12606694 chr6:131520996 AKAP7 0.57 8.54 0.43 5.09e-16 Multiple myeloma (IgH translocation); CRC cis rs12594515 1.000 rs12594515 chr15:45985071 C/G cg01629716 chr15:45996671 NA -0.42 -8.5 -0.42 6.55e-16 Waist circumference;Weight; CRC cis rs10504229 0.639 rs2318145 chr8:58114867 A/G cg24829409 chr8:58192753 C8orf71 -0.54 -7.88 -0.4 4.9e-14 Developmental language disorder (linguistic errors); CRC trans rs3733585 0.648 rs7376155 chr4:9952588 C/T cg26043149 chr18:55253948 FECH -0.5 -7.71 -0.39 1.51e-13 Cleft plate (environmental tobacco smoke interaction); CRC cis rs2836974 0.897 rs13047678 chr21:40708853 C/T cg07074390 chr21:40555500 PSMG1 -0.44 -5.95 -0.31 7.03e-9 Cognitive function; CRC cis rs2153535 0.563 rs1796688 chr6:8536423 A/T cg21535247 chr6:8435926 SLC35B3 0.51 7.79 0.39 9.12e-14 Motion sickness; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg26243254 chr12:132434651 EP400 0.47 6.7 0.35 8.94e-11 Anxiety disorder; CRC cis rs13108904 0.935 rs6853002 chr4:1295991 C/T cg16405210 chr4:1374714 KIAA1530 -0.4 -5.7 -0.3 2.68e-8 Obesity-related traits; CRC cis rs9435341 0.965 rs1730864 chr1:107607810 C/T cg09367891 chr1:107599246 PRMT6 -0.71 -10.53 -0.5 1.58e-22 Facial morphology (factor 21, depth of nasal alae); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg08635118 chr7:6144369 USP42 0.4 6.12 0.32 2.72e-9 Intelligence (multi-trait analysis); CRC cis rs10256972 0.521 rs7811577 chr7:1102829 C/G cg07308232 chr7:1071921 C7orf50 -0.42 -5.95 -0.31 6.79e-9 Longevity;Endometriosis; CRC cis rs7647973 0.961 rs10154992 chr3:49276077 C/T cg07636037 chr3:49044803 WDR6 0.62 7.6 0.39 3.2e-13 Menarche (age at onset); CRC cis rs2949837 0.581 rs1852210 chr7:45994256 C/T cg04796162 chr7:45961102 IGFBP3 0.4 6.82 0.35 4.5e-11 Sitting height ratio; CRC cis rs2115630 0.691 rs2292462 chr15:85200754 G/T cg09876464 chr15:85330779 ZNF592 0.37 6.08 0.32 3.33e-9 P wave terminal force; CRC cis rs2836974 0.829 rs34227163 chr21:40551943 A/G cg06238570 chr21:40685208 BRWD1 0.78 10.73 0.51 3.05e-23 Cognitive function; CRC cis rs977987 0.778 rs4888412 chr16:75443196 A/G cg03315344 chr16:75512273 CHST6 0.54 9.08 0.45 1.01e-17 Dupuytren's disease; CRC cis rs17001868 0.568 rs55769635 chr22:40790101 G/A cg07138101 chr22:40742427 ADSL 0.53 7.32 0.37 1.97e-12 Mammographic density (dense area); CRC cis rs8077889 0.917 rs72836556 chr17:41911824 G/T cg26893861 chr17:41843967 DUSP3 0.97 12.55 0.57 8.7e-30 Triglycerides; CRC cis rs9467773 0.526 rs9688946 chr6:26367445 C/A cg14345882 chr6:26364793 BTN3A2 0.43 6.65 0.34 1.19e-10 Intelligence (multi-trait analysis); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg01685739 chr7:150756773 SLC4A2 0.38 6.25 0.33 1.24e-9 Liver disease severity in Alagille syndrome; CRC cis rs2046867 0.818 rs62249861 chr3:72867779 A/G cg25664220 chr3:72788482 NA -0.46 -6.65 -0.34 1.21e-10 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; CRC cis rs7945705 0.967 rs10840148 chr11:8923528 C/T cg00186954 chr11:8933980 ST5;C11orf17 0.46 7.09 0.36 8.44e-12 Hemoglobin concentration; CRC cis rs875971 0.792 rs6971752 chr7:65737986 G/A cg11764359 chr7:65958608 NA -0.6 -9.24 -0.45 3.1e-18 Aortic root size; CRC cis rs67478160 0.608 rs34066659 chr14:104263427 A/C cg01849466 chr14:104193079 ZFYVE21 -0.47 -8.39 -0.42 1.48e-15 Schizophrenia; CRC cis rs9527 0.551 rs28606370 chr10:104670832 C/A cg04362960 chr10:104952993 NT5C2 0.63 8.93 0.44 3.11e-17 Arsenic metabolism; CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg00748821 chr4:83932227 LIN54 -0.51 -6.22 -0.32 1.54e-9 Diisocyanate-induced asthma; CRC cis rs853679 0.546 rs13214023 chr6:28332141 A/G cg15845792 chr6:28175446 NA -0.79 -5.63 -0.3 3.81e-8 Depression; CRC cis rs597539 0.616 rs513476 chr11:68698996 C/T cg04772025 chr11:68637568 NA 0.48 7.32 0.37 1.89e-12 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs4819052 0.851 rs2330012 chr21:46658592 G/A cg11663144 chr21:46675770 NA -0.83 -14.12 -0.61 9.88e-36 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs45509595 0.841 rs9368531 chr6:27781872 G/C cg19041857 chr6:27730383 NA -0.72 -6.75 -0.35 6.7e-11 Breast cancer; CRC cis rs78456975 1.000 rs11903168 chr2:1560497 C/G cg26248373 chr2:1572462 NA -0.66 -7.2 -0.37 4.09e-12 Placebo response in major depressive disorder (% change in symptom score); CRC cis rs7264396 0.790 rs6060526 chr20:34225302 A/G cg04508476 chr20:34239394 CPNE1;RBM12 0.57 8.75 0.43 1.11e-16 Total cholesterol levels; CRC cis rs853679 0.517 rs9380050 chr6:28048538 A/G cg15786705 chr6:28176104 NA 0.73 9.31 0.46 1.85e-18 Depression; CRC cis rs751728 0.664 rs9394167 chr6:33754396 A/G cg25922239 chr6:33757077 LEMD2 0.46 6.86 0.35 3.49e-11 Crohn's disease; CRC cis rs7666738 0.830 rs17484966 chr4:99014432 T/C cg05340658 chr4:99064831 C4orf37 0.62 9.64 0.47 1.5700000000000001e-19 Colonoscopy-negative controls vs population controls; CRC cis rs4332037 0.539 rs11763750 chr7:2080114 G/A cg23422044 chr7:1970798 MAD1L1 -0.57 -6.91 -0.36 2.53e-11 Bipolar disorder; CRC cis rs972578 0.967 rs4822238 chr22:43364795 G/C cg01576275 chr22:43409880 NA -0.45 -7.21 -0.37 3.88e-12 Mean platelet volume; CRC cis rs875971 0.830 rs6967708 chr7:65657313 A/T cg18252515 chr7:66147081 NA 0.39 5.6 0.3 4.46e-8 Aortic root size; CRC cis rs7618915 0.501 rs3852066 chr3:52621839 C/T cg15147215 chr3:52552868 STAB1 -0.63 -10.88 -0.51 9.7e-24 Bipolar disorder; CRC trans rs8002861 0.905 rs12428350 chr13:44446161 G/A cg17145862 chr1:211918768 LPGAT1 -0.72 -13.07 -0.58 1.01e-31 Leprosy; CRC cis rs1862618 0.853 rs1423621 chr5:56101035 G/T cg03609598 chr5:56110824 MAP3K1 -0.8 -9.77 -0.47 5.96e-20 Initial pursuit acceleration; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg17979863 chr2:231852034 NA 0.51 7.33 0.37 1.76e-12 Response to antipsychotic treatment; CRC cis rs9393692 0.557 rs61324092 chr6:26297392 G/A cg13736514 chr6:26305472 NA -0.45 -7.34 -0.38 1.67e-12 Educational attainment; CRC cis rs853679 0.517 rs9295761 chr6:28147987 A/G cg06470822 chr6:28175283 NA 1.03 13.51 0.6 2.11e-33 Depression; CRC cis rs5769707 0.967 rs2187891 chr22:49994094 C/T cg05373962 chr22:49881684 NA -0.34 -6.32 -0.33 8.52e-10 Monocyte count;Monocyte percentage of white cells; CRC trans rs11039798 0.507 rs56994343 chr11:48896970 G/A cg15704280 chr7:45808275 SEPT13 0.66 6.67 0.35 1.11e-10 Axial length; CRC cis rs936229 0.749 rs8031937 chr15:75181121 A/G cg14664628 chr15:75095509 CSK -0.86 -14.51 -0.62 3.15e-37 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); CRC cis rs5753618 0.583 rs8138596 chr22:31786961 T/A cg22777020 chr22:31556080 RNF185 0.53 6.28 0.33 1.09e-9 Colorectal cancer; CRC trans rs7937682 0.883 rs568506 chr11:111466429 C/T cg18187862 chr3:45730750 SACM1L 0.43 6.14 0.32 2.38e-9 Primary sclerosing cholangitis; CRC cis rs873946 0.586 rs12251911 chr10:134570595 A/G cg27286337 chr10:134555280 INPP5A 0.68 8.55 0.43 4.63e-16 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CRC cis rs17401966 0.838 rs6541089 chr1:10402785 A/G cg19773385 chr1:10388646 KIF1B -0.67 -10.86 -0.51 1.1e-23 Hepatocellular carcinoma; CRC cis rs7618915 0.547 rs35211965 chr3:52685305 C/G cg07507251 chr3:52567010 NT5DC2 0.46 6.6 0.34 1.68e-10 Bipolar disorder; CRC cis rs9733 0.593 rs10888384 chr1:150574256 C/T cg18016565 chr1:150552671 MCL1 -0.49 -7.42 -0.38 9.8e-13 Tonsillectomy; CRC trans rs9393777 0.920 rs35869525 chr6:26946687 C/T cg06606381 chr12:133084897 FBRSL1 -0.98 -6.94 -0.36 2.1e-11 Intelligence (multi-trait analysis); CRC trans rs561341 1.000 rs4795670 chr17:30244839 T/C cg27661571 chr11:113659931 NA -0.55 -6.77 -0.35 5.81e-11 Hip circumference adjusted for BMI; CRC cis rs11098499 0.954 rs71614438 chr4:120371252 G/A cg09307838 chr4:120376055 NA 0.72 11.14 0.52 1.1e-24 Corneal astigmatism; CRC cis rs28386778 0.897 rs894413 chr17:61916347 A/G cg11494091 chr17:61959527 GH2 0.6 10.2 0.49 2.03e-21 Prudent dietary pattern; CRC cis rs28386778 0.897 rs11654841 chr17:61838259 C/T cg07362569 chr17:61921086 SMARCD2 0.38 5.85 0.31 1.2e-8 Prudent dietary pattern; CRC cis rs2739330 0.828 rs4822454 chr22:24255208 G/A cg10150615 chr22:24372951 LOC391322 -0.62 -9.59 -0.47 2.36e-19 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs10971721 0.822 rs56370320 chr9:33865628 T/C cg13495928 chr9:33750294 PRSS3 0.55 5.94 0.31 7.19e-9 Body mass index; CRC cis rs10883723 0.810 rs7072351 chr10:104265047 C/T cg11453585 chr10:104263688 ACTR1A;SUFU 0.9 16.5 0.67 5.24e-45 Allergic disease (asthma, hay fever or eczema); CRC cis rs2051211 0.895 rs2300670 chr3:38555815 A/G cg01465620 chr3:38496096 LOC100128640;ACVR2B -0.46 -5.68 -0.3 3e-8 QRS duration; CRC trans rs877282 1.000 rs2004479 chr10:770854 G/A cg22713356 chr15:30763199 NA 1.17 15.01 0.64 3.69e-39 Uric acid levels; CRC cis rs9372498 0.536 rs62663261 chr6:118900553 T/C cg01339444 chr6:118972232 C6orf204 0.53 5.94 0.31 7.25e-9 Diastolic blood pressure; CRC cis rs7107174 0.901 rs10899498 chr11:78124575 C/G cg02023728 chr11:77925099 USP35 0.4 6.65 0.34 1.25e-10 Testicular germ cell tumor; CRC cis rs2658782 1.000 rs2658781 chr11:93166368 C/T cg15737290 chr11:93063684 CCDC67 -0.48 -6.94 -0.36 2.03e-11 Pulmonary function decline; CRC cis rs3087591 0.708 rs35109242 chr17:29649223 A/G cg24425628 chr17:29625626 OMG;NF1 0.71 13.05 0.58 1.15e-31 Hip circumference; CRC cis rs6860806 0.507 rs2631371 chr5:131703691 G/A cg07395648 chr5:131743802 NA 0.41 5.69 0.3 2.87e-8 Breast cancer; CRC trans rs8073060 0.586 rs225278 chr17:33974170 C/T cg19694781 chr19:47549865 TMEM160 -1.05 -14.85 -0.63 1.57e-38 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; CRC trans rs55675132 0.548 rs75587174 chr1:115373507 G/A cg25493687 chr8:27288214 PTK2B 0.5 6.17 0.32 1.96e-9 Schizophrenia; CRC cis rs7208859 0.573 rs8078182 chr17:29149664 C/T cg13385521 chr17:29058706 SUZ12P 0.57 7.17 0.37 5.13e-12 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs72615157 0.613 rs56089143 chr7:99819844 G/A cg00814883 chr7:100076585 TSC22D4 -0.5 -6.04 -0.32 4.14e-9 Lung function (FEV1/FVC); CRC cis rs947211 0.948 rs863725 chr1:205751196 C/T cg26354017 chr1:205819088 PM20D1 0.43 5.97 0.31 6.11e-9 Parkinson's disease; CRC cis rs2153535 0.563 rs3117071 chr6:8537908 C/T cg21535247 chr6:8435926 SLC35B3 0.5 7.74 0.39 1.2e-13 Motion sickness; CRC cis rs6502050 0.805 rs9915071 chr17:80119138 T/C cg13198984 chr17:80129470 CCDC57 0.47 8.35 0.42 1.88e-15 Life satisfaction; CRC cis rs7647973 1.000 rs10865956 chr3:49581559 C/A cg20833759 chr3:49053208 WDR6;DALRD3 0.55 8.15 0.41 7.88e-15 Menarche (age at onset); CRC cis rs9894429 0.646 rs9904137 chr17:79613925 C/T cg18240062 chr17:79603768 NPLOC4 0.47 7.45 0.38 8.45e-13 Eye color traits; CRC cis rs10791111 1 rs10791111 chr11:130856099 T/G cg12179176 chr11:130786555 SNX19 0.58 8.58 0.43 3.74e-16 Autism spectrum disorder or schizophrenia; CRC cis rs7493 1.000 rs17166875 chr7:95041271 C/T cg20119798 chr7:94954144 PON1 -0.49 -6.17 -0.32 2.01e-9 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs12048904 0.505 rs10493936 chr1:101213335 A/T cg00063077 chr1:101360652 SLC30A7;EXTL2 -0.67 -9.62 -0.47 1.82e-19 Multiple sclerosis; CRC cis rs7705042 0.570 rs12655443 chr5:141467856 G/T cg07392085 chr5:141489673 NDFIP1 0.35 5.76 0.3 1.93e-8 Asthma; CRC cis rs11577318 0.853 rs4450008 chr1:26643860 C/A cg00852783 chr1:26633632 UBXN11 0.47 6.68 0.35 1.02e-10 Granulocyte percentage of myeloid white cells; CRC cis rs7635838 0.892 rs7372723 chr3:11466511 G/A cg00170343 chr3:11313890 ATG7 0.41 6.29 0.33 1.03e-9 HDL cholesterol; CRC cis rs10540 1.000 rs35068485 chr11:466032 A/T cg03576123 chr11:487126 PTDSS2 -1.01 -10.5 -0.5 2e-22 Body mass index; CRC cis rs2576037 0.526 rs2156050 chr18:44455873 A/G cg24750912 chr18:44543259 TCEB3CL;KATNAL2 0.29 5.91 0.31 8.4e-9 Personality dimensions; CRC cis rs11098499 0.954 rs2306455 chr4:120421969 G/A cg09307838 chr4:120376055 NA 0.72 11.05 0.52 2.45e-24 Corneal astigmatism; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg03574882 chr7:151574332 PRKAG2 0.41 6.5 0.34 2.99e-10 Liver disease severity in Alagille syndrome; CRC cis rs4148883 0.689 rs1800760 chr4:100065626 A/T cg13256891 chr4:100009986 ADH5 0.48 6.83 0.35 4.12e-11 Alcohol dependence; CRC cis rs6942756 0.668 rs644723 chr7:129107881 C/T cg02491457 chr7:128862824 NA -0.59 -7.96 -0.4 2.83e-14 White matter hyperintensity burden; CRC cis rs10504229 0.683 rs7838958 chr8:58136968 T/C cg05313129 chr8:58192883 C8orf71 -0.43 -6.11 -0.32 2.74e-9 Developmental language disorder (linguistic errors); CRC cis rs2996428 0.667 rs111640545 chr1:3752792 G/A cg17848003 chr1:3704513 LRRC47 0.4 5.84 0.31 1.25e-8 Red cell distribution width; CRC cis rs9583531 0.891 rs9521906 chr13:111358000 T/G cg24331049 chr13:111365604 ING1 -0.63 -6.69 -0.35 9.49e-11 Coronary artery disease; CRC cis rs6502050 0.871 rs9916649 chr17:80075739 G/A cg22110888 chr17:80059540 CCDC57 -0.42 -6.62 -0.34 1.48e-10 Life satisfaction; CRC cis rs6912958 0.678 rs9450744 chr6:88280529 T/C cg08069147 chr6:88032118 GJB7;C6orf162 -0.57 -8.57 -0.43 4.19e-16 Monocyte percentage of white cells; CRC trans rs11098499 0.738 rs72918577 chr4:120326701 G/A cg25214090 chr10:38739885 LOC399744 0.66 10.35 0.5 6.4e-22 Corneal astigmatism; CRC cis rs2836633 0.929 rs58120977 chr21:40037346 C/T cg05519781 chr21:40033154 ERG 0.69 13.77 0.6 2.19e-34 Coronary artery disease; CRC cis rs3617 0.573 rs62253583 chr3:52928334 G/A cg07507251 chr3:52567010 NT5DC2 -0.4 -6.23 -0.32 1.42e-9 Red blood cell count;Autism spectrum disorder or schizophrenia; CRC cis rs6951245 0.572 rs75818004 chr7:1047572 C/T cg26224354 chr7:1096374 C7orf50;GPR146 -0.93 -7.95 -0.4 3.07e-14 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs4820294 0.669 rs1894532 chr22:38059750 T/C cg21798802 chr22:38057573 PDXP 0.36 5.92 0.31 8.06e-9 Fat distribution (HIV); CRC cis rs877282 0.947 rs7923867 chr10:768094 G/A cg17470449 chr10:769945 NA 0.65 8.4 0.42 1.31e-15 Uric acid levels; CRC cis rs9859260 0.710 rs34906439 chr3:195779706 A/G cg12923728 chr3:195709715 SDHAP1 0.48 6.54 0.34 2.35e-10 Mean corpuscular volume; CRC cis rs2836974 0.897 rs3945 chr21:40566067 A/G cg06238570 chr21:40685208 BRWD1 0.75 10.2 0.49 2.1e-21 Cognitive function; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg14776943 chr17:42201167 HDAC5 0.47 6.6 0.34 1.61e-10 Response to antipsychotic treatment; CRC cis rs7552404 0.883 rs11161493 chr1:76206254 T/A cg03433033 chr1:76189801 ACADM 0.91 13.97 0.61 3.89e-35 Blood metabolite levels;Acylcarnitine levels; CRC cis rs9612 0.950 rs11351 chr19:44271066 A/C cg08581076 chr19:44259116 C19orf61 0.46 6.02 0.32 4.54e-9 Exhaled nitric oxide output; CRC trans rs1265507 0.666 rs2076966 chr12:114869775 T/C cg11700868 chr17:38521232 GJD3 0.42 5.99 0.31 5.5e-9 Percent mammographic density; CRC cis rs7208859 0.623 rs9915546 chr17:29132144 G/T cg01831904 chr17:28903510 LRRC37B2 -0.63 -6.49 -0.34 3.2e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs6921919 0.583 rs1124131 chr6:28380248 A/C cg21251018 chr6:28226885 NKAPL 0.39 5.93 0.31 7.61e-9 Autism spectrum disorder or schizophrenia; CRC cis rs13118159 0.801 rs13147602 chr4:1332175 A/G cg19318889 chr4:1322082 MAEA 0.55 8.0 0.4 2.18e-14 Longevity; CRC cis rs7429990 0.965 rs2166770 chr3:48005673 A/C cg11946769 chr3:48343235 NME6 0.44 5.73 0.3 2.26e-8 Educational attainment (years of education); CRC cis rs798554 1.000 rs798540 chr7:2764130 G/A cg14895029 chr7:2775587 GNA12 -0.44 -6.45 -0.34 3.92e-10 Height; CRC cis rs4713118 0.662 rs469228 chr6:27970704 A/G cg20615401 chr6:28092323 ZSCAN16 0.44 5.77 0.3 1.82e-8 Parkinson's disease; CRC cis rs62064224 0.614 rs9900089 chr17:30772577 C/T cg25809561 chr17:30822961 MYO1D 0.57 10.2 0.49 2.01e-21 Schizophrenia; CRC cis rs6500602 0.647 rs4786514 chr16:4576798 A/C cg06139259 chr16:4526053 HMOX2;NMRAL1 0.45 6.08 0.32 3.31e-9 Schizophrenia; CRC cis rs9549328 0.611 rs72661939 chr13:113617498 C/T cg20742385 chr13:113633654 MCF2L 0.56 9.5 0.46 4.54e-19 Systolic blood pressure; CRC cis rs1707322 0.721 rs28817701 chr1:46186050 C/T cg03146154 chr1:46216737 IPP 0.68 9.94 0.48 1.59e-20 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs9902453 0.808 rs10445400 chr17:28183059 A/G cg26525008 chr17:28256777 EFCAB5;SSH2 0.57 8.49 0.42 7.09e-16 Coffee consumption (cups per day); CRC cis rs6951245 1.000 rs78628466 chr7:1068453 G/C cg26224354 chr7:1096374 C7orf50;GPR146 -0.88 -11.08 -0.52 1.89e-24 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs6598955 0.670 rs3795685 chr1:26601385 A/G cg04990556 chr1:26633338 UBXN11 0.76 12.88 0.58 5.31e-31 Obesity-related traits; CRC cis rs780096 0.565 rs10169261 chr2:27727314 C/T cg24768116 chr2:27665128 KRTCAP3 -0.35 -7.77 -0.39 1.03e-13 Total body bone mineral density; CRC cis rs7762018 1.000 rs4509126 chr6:170068058 A/G cg19338460 chr6:170058176 WDR27 -0.76 -8.3 -0.42 2.78e-15 Thiazide-induced adverse metabolic effects in hypertensive patients; CRC cis rs597539 0.552 rs10896384 chr11:68720011 A/G cg11716795 chr11:68671300 MRPL21;IGHMBP2 -0.77 -12.7 -0.57 2.45e-30 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs9462846 0.881 rs9296402 chr6:42875650 G/A cg21280719 chr6:42927975 GNMT -0.35 -6.66 -0.34 1.13e-10 Blood protein levels; CRC cis rs1046896 0.503 rs12947062 chr17:80686370 A/G cg19046167 chr17:80928561 B3GNTL1 -0.4 -6.27 -0.33 1.12e-9 Glycated hemoglobin levels; CRC cis rs6598955 0.671 rs7550997 chr1:26596080 G/A cg04990556 chr1:26633338 UBXN11 0.53 5.66 0.3 3.23e-8 Obesity-related traits; CRC cis rs13108904 0.535 rs1250101 chr4:1236111 G/A cg02018176 chr4:1364513 KIAA1530 -0.62 -9.78 -0.47 5.43e-20 Obesity-related traits; CRC cis rs1127311 0.901 rs11264223 chr1:154565519 G/A cg17218026 chr1:154582156 ADAR 0.63 10.67 0.51 5.21e-23 C-reactive protein levels or triglyceride levels (pleiotropy); CRC cis rs6500602 0.727 rs2160567 chr16:4535557 C/T cg14951292 chr16:4525986 HMOX2;NMRAL1 0.57 8.78 0.44 9.24e-17 Schizophrenia; CRC cis rs28386778 0.897 rs2727326 chr17:61923016 G/A cg22520471 chr17:61851767 DDX42;CCDC47 0.74 11.65 0.54 1.76e-26 Prudent dietary pattern; CRC cis rs8060686 0.641 rs79375669 chr16:68099262 A/T cg26727032 chr16:67993705 SLC12A4 -0.57 -6.6 -0.34 1.65e-10 HDL cholesterol;Metabolic syndrome; CRC trans rs11039798 0.588 rs6485869 chr11:48576903 G/T cg03929089 chr4:120376271 NA 0.66 7.25 0.37 2.95e-12 Axial length; CRC cis rs4665809 0.627 rs1465720 chr2:26412638 G/T cg04944784 chr2:26401820 FAM59B -0.85 -10.9 -0.52 7.81e-24 Gut microbiome composition (summer); CRC cis rs2708977 0.965 rs12717781 chr2:97249142 G/A cg01950434 chr2:97203154 ARID5A 0.47 6.85 0.35 3.6e-11 Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes; CRC cis rs4665809 0.652 rs2241739 chr2:26411894 C/T cg26119090 chr2:26468346 HADHA;HADHB -0.93 -13.16 -0.59 4.41e-32 Gut microbiome composition (summer); CRC cis rs3820068 0.581 rs16851851 chr1:15929628 C/G cg27534772 chr1:16042836 PLEKHM2 0.54 10.46 0.5 2.7e-22 Systolic blood pressure; CRC cis rs3731896 0.700 rs11903211 chr2:220193434 A/G cg00436969 chr2:220197716 RESP18 -0.46 -6.09 -0.32 3.14e-9 Educational attainment; CRC cis rs10883723 0.773 rs1326193 chr10:104271674 G/T cg04362960 chr10:104952993 NT5C2 -0.43 -5.9 -0.31 9.11e-9 Allergic disease (asthma, hay fever or eczema); CRC cis rs875971 0.898 rs6977501 chr7:65693342 T/C cg11764359 chr7:65958608 NA -0.63 -10.04 -0.48 7.52e-21 Aortic root size; CRC cis rs7215564 0.908 rs79961397 chr17:78687146 T/A cg09596252 chr17:78655493 RPTOR 0.56 6.15 0.32 2.22e-9 Myopia (pathological); CRC cis rs59918340 0.728 rs59172574 chr8:142231945 C/G cg23750338 chr8:142222470 SLC45A4 0.6 11.05 0.52 2.29e-24 Immature fraction of reticulocytes; CRC cis rs13064411 0.696 rs6769516 chr3:113219905 T/C cg18753928 chr3:113234510 CCDC52 -0.7 -10.83 -0.51 1.45e-23 Response to simvastatin treatment (PCSK9 protein level change); CRC cis rs10751667 0.666 rs6597967 chr11:950583 G/T cg23136738 chr11:925521 AP2A2 -0.4 -6.56 -0.34 2.04e-10 Alzheimer's disease (late onset); CRC cis rs1816752 0.905 rs13428 chr13:25009441 C/G cg02811702 chr13:24901961 NA 0.47 6.61 0.34 1.57e-10 Obesity-related traits; CRC cis rs1005277 0.579 rs2504140 chr10:38387579 T/G cg17219203 chr10:38645113 HSD17B7P2 -0.41 -5.76 -0.3 1.9e-8 Extrinsic epigenetic age acceleration; CRC cis rs2976388 0.647 rs2585138 chr8:143808951 C/T cg24046110 chr8:143859143 LYNX1 0.5 8.63 0.43 2.74e-16 Urinary tract infection frequency; CRC cis rs514406 0.929 rs12410420 chr1:53323754 T/C cg08859206 chr1:53392774 SCP2 -0.45 -7.04 -0.36 1.13e-11 Monocyte count; CRC cis rs1949733 1.000 rs2140337 chr4:8502112 A/G cg11789530 chr4:8429930 ACOX3 0.85 12.55 0.57 8.88e-30 Response to antineoplastic agents; CRC cis rs875971 0.545 rs17138149 chr7:65693180 A/G cg11764359 chr7:65958608 NA 0.48 6.12 0.32 2.6e-9 Aortic root size; CRC cis rs4713118 0.824 rs9468229 chr6:27750086 G/A cg19041857 chr6:27730383 NA -0.44 -5.94 -0.31 7.12e-9 Parkinson's disease; CRC cis rs4588572 0.688 rs1594055 chr5:77695088 G/A cg11547950 chr5:77652471 NA -0.51 -7.61 -0.39 2.87e-13 Triglycerides; CRC cis rs1401999 0.807 rs9869029 chr3:183735286 C/G cg01324343 chr3:183735012 ABCC5 0.82 14.96 0.64 5.57e-39 Anterior chamber depth; CRC trans rs7937682 0.889 rs11213969 chr11:111528441 A/G cg18187862 chr3:45730750 SACM1L 0.49 7.05 0.36 1.07e-11 Primary sclerosing cholangitis; CRC cis rs1355223 0.902 rs11605785 chr11:34751387 G/A cg11058730 chr11:34937778 PDHX;APIP -0.42 -5.75 -0.3 2.01e-8 Systemic lupus erythematosus and Systemic sclerosis; CRC cis rs9768139 0.733 rs921617 chr7:158118198 A/G cg23298862 chr7:158159286 PTPRN2 0.38 5.98 0.31 5.8e-9 Calcium levels; CRC cis rs11122272 0.735 rs10489610 chr1:231517765 C/A cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.54 -8.09 -0.41 1.18e-14 Hemoglobin concentration; CRC cis rs6540556 0.608 rs3817821 chr1:209918503 A/T cg23920097 chr1:209922102 NA -0.5 -6.26 -0.33 1.17e-9 Red blood cell count; CRC cis rs17270561 1.000 rs17270561 chr6:25820439 A/C cg17691542 chr6:26056736 HIST1H1C -0.84 -9.6 -0.47 2.18e-19 Iron status biomarkers; CRC cis rs2836974 0.932 rs2836953 chr21:40617483 G/A cg11644478 chr21:40555479 PSMG1 0.81 12.99 0.58 1.95e-31 Cognitive function; CRC cis rs12701220 0.655 rs12702117 chr7:1148702 T/C cg02733842 chr7:1102375 C7orf50 -0.66 -8.04 -0.41 1.62e-14 Bronchopulmonary dysplasia; CRC cis rs4665809 0.618 rs7579199 chr2:26266496 G/A cg25036284 chr2:26402008 FAM59B -0.46 -6.0 -0.31 5.14e-9 Gut microbiome composition (summer); CRC cis rs2380220 0.640 rs9320386 chr6:95994955 T/C cg15832292 chr6:96025679 MANEA 0.58 6.02 0.32 4.57e-9 Behavioural disinhibition (generation interaction); CRC cis rs4692589 0.772 rs34642369 chr4:170973469 G/A cg19918862 chr4:170955249 NA 0.46 6.99 0.36 1.56e-11 Anxiety disorder; CRC cis rs853679 0.517 rs55747925 chr6:28044337 T/C cg02631126 chr6:28058918 ZSCAN12L1 0.29 6.1 0.32 2.95e-9 Depression; CRC cis rs1799949 1.000 rs72829113 chr17:41181835 C/T cg25072359 chr17:41440525 NA 0.47 6.92 0.36 2.32e-11 Menopause (age at onset); CRC cis rs867529 0.620 rs335121 chr2:89084327 G/C cg26627705 chr2:89060884 NA 0.56 7.41 0.38 1.1e-12 Height; CRC cis rs3862030 0.810 rs5870 chr10:104239100 A/G cg11453585 chr10:104263688 ACTR1A;SUFU -0.78 -13.81 -0.61 1.57e-34 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for body mass index; CRC cis rs951366 0.966 rs11240565 chr1:205722958 C/T cg11965913 chr1:205819406 PM20D1 -0.39 -5.65 -0.3 3.39e-8 Menarche (age at onset); CRC cis rs801193 0.636 rs2659895 chr7:66196471 C/A cg00343986 chr7:65444356 GUSB 0.44 6.19 0.32 1.77e-9 Aortic root size; CRC cis rs2795502 1.000 rs2795508 chr10:43353555 G/T cg27426351 chr10:43362370 NA 0.54 6.65 0.34 1.2e-10 Blood protein levels; CRC cis rs919433 0.713 rs10172961 chr2:198446859 T/C cg10820045 chr2:198174542 NA 0.41 7.05 0.36 1.03e-11 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC cis rs7843479 0.543 rs10866823 chr8:21781629 C/T cg17168535 chr8:21777572 XPO7 0.69 11.61 0.54 2.37e-26 Mean corpuscular volume; CRC cis rs7131987 0.650 rs10843377 chr12:29437053 C/G cg09582351 chr12:29534625 ERGIC2 0.34 7.48 0.38 6.8e-13 QT interval; CRC cis rs4664293 0.605 rs12991516 chr2:160442065 A/G cg08347373 chr2:160653686 CD302 -0.35 -5.85 -0.31 1.17e-8 Monocyte percentage of white cells; CRC cis rs950169 0.887 rs220333 chr15:85091133 C/T cg03959625 chr15:84868606 LOC388152 0.39 5.76 0.3 1.93e-8 Schizophrenia; CRC cis rs4481887 0.962 rs12037921 chr1:248454167 T/G cg00666640 chr1:248458726 OR2T12 0.53 9.53 0.47 3.48e-19 Common traits (Other); CRC trans rs1997103 0.871 rs9649855 chr7:55410222 T/C cg20935933 chr6:143382018 AIG1 0.5 6.54 0.34 2.38e-10 QRS interval (sulfonylurea treatment interaction); CRC cis rs2456568 0.805 rs55784864 chr11:93682887 G/A cg26875233 chr11:93583750 C11orf90 -0.34 -6.59 -0.34 1.79e-10 Response to serotonin reuptake inhibitors in major depressive disorder; CRC trans rs6095360 0.546 rs6012562 chr20:47535261 A/C cg02963556 chr12:132588637 EP400NL 0.4 6.08 0.32 3.33e-9 Intelligence (multi-trait analysis); CRC cis rs9287719 0.649 rs10208103 chr2:10720867 G/A cg00105475 chr2:10696890 NA 0.45 7.06 0.36 9.97e-12 Prostate cancer; CRC trans rs12599106 0.792 rs76039834 chr16:34598453 G/A cg21548813 chr6:291882 DUSP22 -0.52 -7.34 -0.38 1.68e-12 Menopause (age at onset); CRC cis rs10206020 0.921 rs72776300 chr2:1571152 A/G cg26248373 chr2:1572462 NA -0.85 -12.51 -0.57 1.18e-29 IgG glycosylation; CRC cis rs9393692 0.905 rs6916289 chr6:26289122 A/T cg00631329 chr6:26305371 NA -0.68 -13.3 -0.59 1.32e-32 Educational attainment; CRC cis rs9322193 0.962 rs2065664 chr6:150083621 A/G cg13206674 chr6:150067644 NUP43 0.53 7.62 0.39 2.77e-13 Lung cancer; CRC cis rs13108904 0.870 rs4974578 chr4:1266072 A/G cg05665937 chr4:1216051 CTBP1 0.41 5.91 0.31 8.46e-9 Obesity-related traits; CRC cis rs4665809 0.838 rs2243834 chr2:26357748 A/C cg25036284 chr2:26402008 FAM59B 0.45 5.93 0.31 7.47e-9 Gut microbiome composition (summer); CRC cis rs61677309 1.000 rs1599809 chr11:118179200 G/A cg06090739 chr11:118230722 UBE4A 0.42 5.72 0.3 2.34e-8 Lung cancer in ever smokers; CRC cis rs13191362 1.000 rs34931503 chr6:163003876 T/C cg23758597 chr6:163146217 PARK2 -0.55 -6.13 -0.32 2.54e-9 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs11098499 0.863 rs3775843 chr4:120427844 T/C cg24375607 chr4:120327624 NA 0.47 7.16 0.37 5.26e-12 Corneal astigmatism; CRC trans rs9858542 0.953 rs6779524 chr3:49450449 C/T cg21582582 chr3:182698605 DCUN1D1 -0.52 -6.63 -0.34 1.41e-10 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs847577 0.515 rs10953238 chr7:97676259 C/T cg21770322 chr7:97807741 LMTK2 0.78 16.64 0.68 1.61e-45 Breast cancer; CRC cis rs4253772 0.591 rs6519994 chr22:46656805 A/G cg03482458 chr22:46692211 CN5H6.4;GTSE1 -0.5 -6.85 -0.35 3.69e-11 LDL cholesterol;Cholesterol, total; CRC cis rs10504229 0.636 rs10958525 chr8:58051528 C/A cg21724239 chr8:58056113 NA 0.58 7.75 0.39 1.16e-13 Developmental language disorder (linguistic errors); CRC cis rs7246657 1.000 rs35398388 chr19:37740358 A/G cg23950597 chr19:37808831 NA -0.54 -6.25 -0.33 1.3e-9 Coronary artery calcification; CRC cis rs1941023 0.503 rs4939350 chr11:60136243 C/G cg08716584 chr11:60157161 MS4A7 -0.53 -8.79 -0.44 8.32e-17 Congenital heart disease (maternal effect); CRC cis rs7312933 0.584 rs7974654 chr12:42630466 C/A cg11827402 chr12:42719852 PPHLN1;ZCRB1 0.62 8.84 0.44 5.92e-17 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CRC cis rs7586879 0.616 rs916485 chr2:25082273 T/C cg22495460 chr2:25135724 ADCY3 -0.82 -15.44 -0.65 7.85e-41 Body mass index; CRC cis rs7647973 0.626 rs62262722 chr3:49769419 G/C cg03060546 chr3:49711283 APEH -0.6 -6.72 -0.35 8.19e-11 Menarche (age at onset); CRC cis rs6076065 0.748 rs6048784 chr20:23382652 A/T cg11657817 chr20:23433608 CST11 0.54 9.32 0.46 1.76e-18 Facial morphology (factor 15, philtrum width); CRC cis rs10504229 0.683 rs16921829 chr8:58110950 A/G cg22535103 chr8:58192502 C8orf71 -0.69 -8.95 -0.44 2.61e-17 Developmental language disorder (linguistic errors); CRC cis rs7618915 0.533 rs35107891 chr3:52613656 G/C cg15147215 chr3:52552868 STAB1 -0.63 -10.56 -0.5 1.22e-22 Bipolar disorder; CRC cis rs3825932 0.736 rs1036939 chr15:79237324 C/A cg25744700 chr15:79237217 CTSH 0.38 5.82 0.31 1.41e-8 Type 1 diabetes; CRC trans rs2243480 1.000 rs2177703 chr7:65391717 C/A cg10756647 chr7:56101905 PSPH 0.73 8.07 0.41 1.36e-14 Diabetic kidney disease; CRC cis rs12477438 0.539 rs12999417 chr2:99865548 A/G cg26064155 chr2:99771622 LIPT1;TSGA10 -0.84 -15.22 -0.64 5.64e-40 Chronic sinus infection; CRC cis rs514406 0.644 rs6662414 chr1:53198893 A/G cg27535305 chr1:53392650 SCP2 0.34 6.3 0.33 9.79e-10 Monocyte count; CRC cis rs68170813 0.559 rs77727587 chr7:106815754 C/G cg02696742 chr7:106810147 HBP1 -0.64 -7.29 -0.37 2.38e-12 Coronary artery disease; CRC cis rs6754311 0.773 rs309130 chr2:136631031 C/A cg15123519 chr2:136567270 LCT 0.35 6.87 0.35 3.17e-11 Mosquito bite size; CRC cis rs17270561 0.609 rs2154218 chr6:25776290 T/C cg16482183 chr6:26056742 HIST1H1C 0.74 9.2 0.45 4.38e-18 Iron status biomarkers; CRC cis rs4604732 0.536 rs10925056 chr1:247650472 T/C cg12758973 chr1:247694275 LOC148824;OR2C3 0.46 6.68 0.35 1.01e-10 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CRC cis rs7119 0.651 rs34829483 chr15:77835986 C/T cg10437265 chr15:77819839 NA 0.68 12.05 0.55 5.92e-28 Type 2 diabetes; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg08720519 chr16:70558200 SF3B3;COG4 0.44 6.01 0.31 4.86e-9 Response to antipsychotic treatment; CRC cis rs13064411 0.627 rs9825827 chr3:113182231 T/C cg10517650 chr3:113235015 CCDC52 -0.37 -6.58 -0.34 1.83e-10 Response to simvastatin treatment (PCSK9 protein level change); CRC cis rs6840360 0.868 rs6823462 chr4:152708740 G/A cg09659197 chr4:152720779 NA 0.54 11.65 0.54 1.66e-26 Intelligence (multi-trait analysis); CRC trans rs1814175 0.754 rs10839453 chr11:49955815 A/T cg03929089 chr4:120376271 NA -0.98 -19.37 -0.73 2.6e-56 Height; CRC cis rs4936891 0.577 rs4565912 chr11:123904395 A/G cg22125253 chr11:123886957 OR10G4 -0.33 -5.79 -0.3 1.63e-8 Male fertility; CRC cis rs6088813 1.000 rs6087702 chr20:33995945 T/A cg14752227 chr20:34000481 UQCC -0.36 -5.6 -0.3 4.45e-8 Height; CRC cis rs9443645 0.527 rs12194642 chr6:79538791 G/A cg05283184 chr6:79620031 NA -0.44 -6.38 -0.33 5.98e-10 Intelligence (multi-trait analysis); CRC cis rs4819052 0.851 rs2838844 chr21:46670733 A/C cg11663144 chr21:46675770 NA -0.85 -14.78 -0.63 2.8900000000000003e-38 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs7607369 0.559 rs4674340 chr2:219659799 A/G cg02176678 chr2:219576539 TTLL4 -0.39 -6.35 -0.33 6.97e-10 Red blood cell count;Amyotrophic lateral sclerosis; CRC cis rs1005277 0.579 rs2472182 chr10:38388865 T/C cg25517755 chr10:38738941 LOC399744 -0.44 -6.41 -0.33 5.05e-10 Extrinsic epigenetic age acceleration; CRC cis rs1580019 0.961 rs6949851 chr7:32493807 T/G cg06627557 chr7:32535165 LSM5;AVL9 0.76 12.06 0.55 5.61e-28 Cognitive ability; CRC cis rs6586163 1.000 rs3824729 chr10:90752616 A/G cg03111039 chr10:90751583 FAS;ACTA2 -0.51 -7.47 -0.38 7.23e-13 Chronic lymphocytic leukemia; CRC trans rs2243480 1.000 rs781157 chr7:65478311 G/A cg10756647 chr7:56101905 PSPH 0.74 8.12 0.41 9.34e-15 Diabetic kidney disease; CRC cis rs7607369 0.580 rs17573731 chr2:219652153 T/C cg02176678 chr2:219576539 TTLL4 -0.56 -9.01 -0.44 1.76e-17 Red blood cell count;Amyotrophic lateral sclerosis; CRC cis rs7818382 1.000 rs7818382 chr8:96054000 C/T cg16049864 chr8:95962084 TP53INP1 -0.59 -10.02 -0.48 8.4e-21 Alzheimer's disease (late onset); CRC cis rs514406 0.825 rs1242328 chr1:53396869 A/G cg24675658 chr1:53192096 ZYG11B -0.58 -8.54 -0.43 5.22e-16 Monocyte count; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg03884976 chr16:577621 SOLH;C16orf10 0.47 6.3 0.33 9.53e-10 Anxiety disorder; CRC cis rs7591163 1.000 rs1039665 chr2:228717392 A/G cg00063174 chr2:228736253 WDR69 -0.51 -6.88 -0.35 3.07e-11 Blood pressure; CRC cis rs34034915 1 rs34034915 chr6:27720703 T/TG cg12172441 chr6:28176163 NA 0.47 6.53 0.34 2.49e-10 Hepatitis A; CRC cis rs7786808 0.707 rs10247026 chr7:158230595 C/T cg15440763 chr7:158190612 PTPRN2 0.4 6.31 0.33 8.9e-10 Obesity-related traits; CRC trans rs10504390 0.656 rs79932695 chr8:66547075 T/C cg26403416 chr21:43771339 TFF2 0.6 6.14 0.32 2.38e-9 IgG glycosylation; CRC cis rs1008375 1.000 rs2215450 chr4:17675394 T/G cg16339924 chr4:17578868 LAP3 0.48 6.14 0.32 2.41e-9 Parasitemia in Tripanosoma cruzi seropositivity; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg21446345 chr15:70390985 TLE3 0.45 6.54 0.34 2.37e-10 Response to antipsychotic treatment; CRC cis rs17092148 0.616 rs6059908 chr20:33132159 T/C cg08999081 chr20:33150536 PIGU 0.46 5.67 0.3 3.09e-8 Neuroticism; CRC cis rs9326248 0.501 rs4938351 chr11:117022352 A/C cg11861562 chr11:117069780 TAGLN 0.31 6.91 0.36 2.5e-11 Blood protein levels; CRC cis rs8141529 0.764 rs5752812 chr22:29225603 T/A cg15103426 chr22:29168792 CCDC117 0.59 8.56 0.43 4.41e-16 Lymphocyte counts; CRC cis rs753778 0.629 rs2278447 chr8:142206905 G/C cg18755752 chr8:142205143 DENND3 -0.65 -11.21 -0.53 6.38e-25 Reticulocyte fraction of red cells;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; CRC cis rs12188164 0.686 rs56279338 chr5:416118 G/A cg26850624 chr5:429559 AHRR -0.74 -12.25 -0.56 1.1e-28 Cystic fibrosis severity; CRC cis rs929354 0.742 rs2051877 chr7:157008813 A/T cg16102536 chr7:156981717 UBE3C 0.4 6.71 0.35 8.48e-11 Body mass index; CRC cis rs2019137 0.560 rs4849179 chr2:113985170 C/T cg01577475 chr2:114033581 PAX8;LOC440839 -0.25 -6.28 -0.33 1.06e-9 Lymphocyte counts; CRC cis rs17539620 0.624 rs62432740 chr6:154836054 C/T cg20019720 chr6:154832845 CNKSR3 0.5 8.15 0.41 7.48e-15 Lipoprotein (a) levels; CRC cis rs10046574 0.561 rs10214966 chr7:135196642 A/G cg27474649 chr7:135195673 CNOT4 0.67 6.16 0.32 2.14e-9 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs863345 0.504 rs2482966 chr1:158563321 T/A cg12129480 chr1:158549410 OR10X1 -0.34 -7.17 -0.37 4.96e-12 Pneumococcal bacteremia; CRC cis rs6938 0.597 rs11856413 chr15:75199892 A/G cg05627522 chr15:75251581 NA 0.4 5.99 0.31 5.36e-9 Breast cancer; CRC trans rs2832077 0.824 rs4816333 chr21:30201777 C/G cg14791747 chr16:20752902 THUMPD1 0.53 6.51 0.34 2.8e-10 Cognitive test performance; CRC cis rs28386778 0.897 rs894407 chr17:61901641 T/C cg23090583 chr17:61904693 PSMC5;FTSJ3 1.05 20.68 0.75 1.83e-61 Prudent dietary pattern; CRC cis rs9914266 1 rs9914266 chr17:2133250 T/C cg16513277 chr17:2031491 SMG6 -0.52 -8.79 -0.44 8.39e-17 Myocardial infarction; CRC cis rs67478160 0.643 rs8005225 chr14:104300151 C/T cg08213375 chr14:104286397 PPP1R13B -0.65 -13.7 -0.6 4.08e-34 Schizophrenia; CRC trans rs6788895 1.000 rs6795396 chr3:150510227 C/T cg12790874 chr13:100310405 CLYBL -0.69 -6.04 -0.32 4.06e-9 Breast cancer; CRC cis rs1953600 0.837 rs2819946 chr10:81951635 G/A cg00277334 chr10:82204260 NA 0.38 6.08 0.32 3.37e-9 Sarcoidosis; CRC cis rs4972806 0.814 rs1446575 chr2:177047801 A/C cg09355771 chr2:177043147 NA 0.69 10.74 0.51 2.94e-23 IgG glycosylation; CRC cis rs875971 0.862 rs28470208 chr7:65584700 A/G cg11764359 chr7:65958608 NA -0.58 -8.9 -0.44 3.92e-17 Aortic root size; CRC cis rs4332037 0.722 rs4721140 chr7:1917635 A/T cg21155852 chr7:2048760 MAD1L1 -0.4 -5.66 -0.3 3.25e-8 Bipolar disorder; CRC trans rs1455244 0.700 rs7229302 chr18:11508904 G/T cg19590290 chr4:104119639 CENPE 0.4 6.34 0.33 7.7e-10 Schizophrenia; CRC cis rs6062302 0.548 rs4809310 chr20:62228745 G/A cg16989086 chr20:62203971 PRIC285 0.47 6.03 0.32 4.52e-9 Glioblastoma; CRC cis rs853679 0.517 rs9368553 chr6:28082265 T/C cg15845792 chr6:28175446 NA 1.0 13.1 0.59 7.81e-32 Depression; CRC cis rs6694672 1.000 rs857017 chr1:197019055 T/C cg13682187 chr1:196946512 CFHR5 0.48 7.43 0.38 9.48e-13 Asthma; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg08252325 chr2:71098940 NA 0.4 6.28 0.33 1.08e-9 Response to antipsychotic treatment; CRC cis rs6534441 0.818 rs11946186 chr4:125457073 C/T cg21609808 chr4:125404261 NA 0.39 5.88 0.31 9.92e-9 Major depressive disorder; CRC cis rs3733585 0.673 rs4292332 chr4:9953830 C/A cg00071950 chr4:10020882 SLC2A9 -0.55 -9.74 -0.47 7.09e-20 Cleft plate (environmental tobacco smoke interaction); CRC trans rs6561151 0.957 rs9316058 chr13:44485076 G/C cg17145862 chr1:211918768 LPGAT1 0.5 7.13 0.37 6.38e-12 Crohn's disease; CRC cis rs1552244 0.882 rs67895180 chr3:10026079 T/C cg02579736 chr3:10068473 FANCD2;CIDECP 0.93 11.94 0.55 1.55e-27 Alzheimer's disease; CRC cis rs9311676 0.632 rs4130877 chr3:58374893 T/C cg06643156 chr3:58380774 PXK 0.41 6.33 0.33 7.82e-10 Systemic lupus erythematosus; CRC cis rs16975963 0.545 rs12461753 chr19:38202515 G/A cg15135657 chr19:38346511 NA -0.49 -6.53 -0.34 2.48e-10 Longevity; CRC cis rs7705042 0.865 rs249642 chr5:141524980 G/C cg07392085 chr5:141489673 NDFIP1 0.45 7.25 0.37 2.94e-12 Asthma; CRC cis rs629535 0.748 rs689410 chr8:70037558 G/A cg26132723 chr8:70041827 NA 0.35 5.72 0.3 2.41e-8 Dupuytren's disease; CRC cis rs6665290 0.904 rs1186 chr1:227177731 A/T cg10327440 chr1:227177885 CDC42BPA -1.04 -23.9 -0.8 7.05e-74 Myeloid white cell count; CRC cis rs9560113 1.000 rs9555809 chr13:112181401 T/C cg10483660 chr13:112241077 NA 0.36 5.78 0.3 1.76e-8 Menarche (age at onset); CRC cis rs12540874 0.698 rs10899736 chr7:50546925 C/T cg14593290 chr7:50529359 DDC -0.46 -6.54 -0.34 2.35e-10 Systemic sclerosis; CRC cis rs7726839 0.507 rs111707179 chr5:593308 T/A cg16447950 chr5:562315 NA -0.73 -9.79 -0.47 5.05e-20 Obesity-related traits; CRC cis rs4481887 0.741 rs6587458 chr1:248532290 T/A cg00666640 chr1:248458726 OR2T12 0.43 7.64 0.39 2.34e-13 Common traits (Other); CRC cis rs6973256 0.897 rs9656424 chr7:133325031 A/T cg10665199 chr7:133106180 EXOC4 -0.38 -5.84 -0.31 1.28e-8 Intelligence (multi-trait analysis); CRC cis rs1348850 0.914 rs4893950 chr2:178304885 T/C cg02961200 chr2:178257176 LOC100130691;AGPS 0.63 9.27 0.45 2.57e-18 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs4665809 1.000 rs750451 chr2:26324241 G/A cg22920501 chr2:26401640 FAM59B -0.52 -7.15 -0.37 5.68e-12 Gut microbiome composition (summer); CRC cis rs7618915 0.501 rs9917834 chr3:52634619 A/C cg15147215 chr3:52552868 STAB1 -0.63 -10.88 -0.51 9.7e-24 Bipolar disorder; CRC cis rs8072100 0.846 rs6503796 chr17:45765249 T/C cg25173405 chr17:45401733 C17orf57 -0.4 -6.08 -0.32 3.26e-9 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs4805272 0.512 rs11879141 chr19:29320335 G/A cg12756686 chr19:29218302 NA 0.47 6.25 0.33 1.27e-9 Plasma omega-3 polyunsaturated fatty acid levels (docosahexaenoic acid); CRC cis rs13256369 0.950 rs13248096 chr8:8577476 C/T cg00074818 chr8:8560427 CLDN23 0.36 6.71 0.35 8.71e-11 Obesity-related traits; CRC cis rs10504229 0.639 rs2318145 chr8:58114867 A/G cg05313129 chr8:58192883 C8orf71 -0.43 -6.0 -0.31 5.07e-9 Developmental language disorder (linguistic errors); CRC cis rs9487051 0.802 rs9487039 chr6:109610163 A/T cg21918786 chr6:109611834 NA -0.45 -8.32 -0.42 2.32e-15 Reticulocyte fraction of red cells; CRC trans rs11098499 0.754 rs34425882 chr4:120253177 G/A cg25214090 chr10:38739885 LOC399744 0.53 8.36 0.42 1.81e-15 Corneal astigmatism; CRC cis rs7618915 0.547 rs34017441 chr3:52742413 T/C cg08222913 chr3:52553049 STAB1 -0.35 -6.24 -0.33 1.34e-9 Bipolar disorder; CRC cis rs910316 1.000 rs175512 chr14:75523382 T/C cg11812906 chr14:75593930 NEK9 -0.63 -10.01 -0.48 9.17e-21 Height; CRC cis rs863345 0.604 rs10908665 chr1:158499889 T/A cg12129480 chr1:158549410 OR10X1 -0.3 -6.27 -0.33 1.12e-9 Pneumococcal bacteremia; CRC trans rs10983614 1.000 rs7867776 chr9:120072627 A/G cg27641522 chr18:53447560 NA 0.33 6.1 0.32 2.98e-9 Survival in pancreatic cancer; CRC cis rs2949837 0.655 rs11977526 chr7:46008110 G/A cg15898840 chr7:45960834 IGFBP3 0.53 8.36 0.42 1.82e-15 Sitting height ratio; CRC cis rs611744 0.604 rs13248461 chr8:109285833 C/T cg21045802 chr8:109455806 TTC35 0.46 7.29 0.37 2.33e-12 Dupuytren's disease; CRC cis rs597539 0.652 rs602805 chr11:68662076 A/T cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.9 15.49 0.65 5.06e-41 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC trans rs7705042 0.865 rs6580228 chr5:141510448 C/T cg03701575 chr16:83960119 NA 0.35 5.98 0.31 5.73e-9 Asthma; CRC cis rs9787249 0.957 rs1046988 chr1:40219065 A/G cg01941586 chr1:40203715 PPIE 0.44 6.22 0.32 1.53e-9 Blood protein levels; CRC cis rs73206853 0.688 rs57530940 chr12:110597842 C/T cg12870014 chr12:110450643 ANKRD13A 0.79 8.0 0.4 2.21e-14 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC cis rs1552244 0.882 rs56224841 chr3:10044014 A/C cg16606324 chr3:10149918 C3orf24 0.62 8.08 0.41 1.25e-14 Alzheimer's disease; CRC cis rs6540559 0.740 rs2064163 chr1:210048819 G/T cg23283495 chr1:209979779 IRF6 0.37 5.67 0.3 3.2e-8 Cleft lip with or without cleft palate; CRC trans rs637571 0.528 rs566266 chr11:65573587 A/C cg17712092 chr4:129076599 LARP1B -0.54 -8.27 -0.41 3.34e-15 Eosinophil percentage of white cells; CRC cis rs72781680 0.898 rs12619592 chr2:23971415 C/A cg08917208 chr2:24149416 ATAD2B 0.86 8.45 0.42 9.69e-16 Lymphocyte counts; CRC cis rs6893300 0.506 rs35320050 chr5:179131013 C/T cg14593053 chr5:179126677 CANX 0.49 7.69 0.39 1.76e-13 Resting heart rate; CRC cis rs9902453 0.967 rs4294864 chr17:28440138 G/C cg26525008 chr17:28256777 EFCAB5;SSH2 0.59 8.82 0.44 6.76e-17 Coffee consumption (cups per day); CRC cis rs9291683 0.561 rs3733584 chr4:10036506 T/C cg00071950 chr4:10020882 SLC2A9 0.67 12.67 0.57 3.24e-30 Bone mineral density; CRC cis rs9311474 0.652 rs352158 chr3:52217704 C/T cg15147215 chr3:52552868 STAB1 -0.45 -7.24 -0.37 3.17e-12 Electroencephalogram traits; CRC cis rs2549003 1.000 rs2070722 chr5:131824486 A/C cg00255919 chr5:131827918 IRF1 0.58 11.35 0.53 1.99e-25 Asthma (sex interaction); CRC cis rs9549367 0.789 rs3794422 chr13:113893729 G/A cg00898013 chr13:113819073 PROZ -0.45 -6.44 -0.33 4.14e-10 Platelet distribution width; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg15508020 chr16:58232206 CSNK2A2 0.48 6.83 0.35 4.04e-11 Response to antipsychotic treatment; CRC cis rs1552244 0.766 rs34232505 chr3:10186216 T/A cg13047869 chr3:10149882 C3orf24 0.56 7.51 0.38 5.62e-13 Alzheimer's disease; CRC trans rs1814175 0.616 rs1794131 chr11:49904194 A/G cg11707556 chr5:10655725 ANKRD33B -0.53 -10.19 -0.49 2.21e-21 Height; CRC cis rs9811920 0.638 rs793503 chr3:99588070 A/G cg08350549 chr3:99591722 C3orf26;FILIP1L;MIR548G 0.37 5.7 0.3 2.66e-8 Axial length; CRC cis rs2108225 1.000 rs6466191 chr7:107453511 A/T cg18560240 chr7:107437656 SLC26A3 -0.58 -8.81 -0.44 7.58e-17 Ulcerative colitis; CRC cis rs4604732 0.578 rs12036417 chr1:247624805 T/C cg12754571 chr1:247694271 LOC148824;OR2C3 0.41 5.78 0.3 1.74e-8 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CRC cis rs853679 0.513 rs9468296 chr6:28113730 A/G cg15786705 chr6:28176104 NA 0.78 9.83 0.48 3.57e-20 Depression; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg10524888 chr4:39529563 UGDH 0.4 6.53 0.34 2.55e-10 Liver disease severity in Alagille syndrome; CRC cis rs7824557 0.527 rs57629785 chr8:11235150 C/A cg08071915 chr8:12219732 FAM66A 0.32 5.77 0.3 1.82e-8 Retinal vascular caliber; CRC cis rs929354 0.707 rs1182445 chr7:157024428 C/G cg05182265 chr7:156933206 UBE3C 0.76 14.55 0.63 2.33e-37 Body mass index; CRC cis rs7186831 1 rs7186831 chr16:75473155 G/A cg03315344 chr16:75512273 CHST6 0.56 9.57 0.47 2.62e-19 Chronic obstructive pulmonary disease; CRC trans rs7615952 0.512 rs2979336 chr3:125357470 G/A cg03844506 chr4:4109441 NA -0.5 -7.42 -0.38 1.01e-12 Blood pressure (smoking interaction); CRC cis rs6952808 0.636 rs6964522 chr7:1953523 C/T cg14004847 chr7:1930337 MAD1L1 -0.41 -6.06 -0.32 3.75e-9 Bipolar disorder and schizophrenia; CRC cis rs1801251 0.896 rs6719061 chr2:233695885 C/T cg25237894 chr2:233734115 C2orf82 -0.45 -7.12 -0.37 6.86e-12 Coronary artery disease; CRC cis rs9902453 0.933 rs8074028 chr17:28461687 T/C cg26525008 chr17:28256777 EFCAB5;SSH2 0.61 9.7 0.47 1.03e-19 Coffee consumption (cups per day); CRC cis rs1552244 1.000 rs7622963 chr3:10139825 C/T cg00166722 chr3:10149974 C3orf24 0.63 8.78 0.44 9.09e-17 Alzheimer's disease; CRC cis rs62064224 0.589 rs2041306 chr17:30665675 T/C cg21839984 chr17:30846986 MYO1D -0.34 -5.62 -0.3 4.07e-8 Schizophrenia; CRC cis rs1448094 0.511 rs4469976 chr12:86146723 T/C cg19622623 chr12:86230825 RASSF9 0.4 6.15 0.32 2.22e-9 Major depressive disorder; CRC cis rs5758511 0.773 rs9623482 chr22:42360574 T/C cg00645731 chr22:42541494 CYP2D7P1 0.5 7.46 0.38 7.8e-13 Birth weight; CRC cis rs10504229 0.683 rs56408763 chr8:58137276 G/A cg22535103 chr8:58192502 C8orf71 -0.7 -9.34 -0.46 1.47e-18 Developmental language disorder (linguistic errors); CRC cis rs12681287 0.571 rs10097450 chr8:87358677 G/A cg27223183 chr8:87520930 FAM82B 0.53 7.19 0.37 4.51e-12 Caudate activity during reward; CRC cis rs881375 1.000 rs6478484 chr9:123652380 T/C cg09586646 chr9:123605570 PSMD5;LOC253039 0.53 7.19 0.37 4.36e-12 Rheumatoid arthritis; CRC cis rs7811142 1.000 rs4989959 chr7:100032288 T/C cg00814883 chr7:100076585 TSC22D4 -0.74 -9.42 -0.46 8.21e-19 Platelet count; CRC cis rs6758955 0.850 rs6743846 chr2:10480415 A/G cg15773312 chr2:10472214 HPCAL1 0.83 9.69 0.47 1.04e-19 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; CRC cis rs172166 0.694 rs1150666 chr6:28123928 T/C cg15786705 chr6:28176104 NA 0.63 9.0 0.44 1.89e-17 Cardiac Troponin-T levels; CRC cis rs938554 0.513 rs10939650 chr4:9998440 C/T cg00071950 chr4:10020882 SLC2A9 0.45 7.11 0.37 7.08e-12 Blood metabolite levels; CRC cis rs4285028 0.948 rs34478505 chr3:121694071 C/T cg11130432 chr3:121712080 ILDR1 -0.52 -6.77 -0.35 6.09e-11 Multiple sclerosis; CRC cis rs7224685 0.501 rs781827 chr17:3962965 G/A cg21851534 chr17:3907994 ZZEF1 0.37 6.46 0.34 3.69e-10 Type 2 diabetes; CRC cis rs1707322 0.686 rs3014239 chr1:46089801 G/A cg03146154 chr1:46216737 IPP -0.66 -9.39 -0.46 1.04e-18 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs3768617 0.510 rs2333620 chr1:183100555 T/C ch.1.3577855R chr1:183094577 LAMC1 0.89 15.85 0.66 1.88e-42 Fuchs's corneal dystrophy; CRC cis rs66573146 0.831 rs56300156 chr4:6990813 G/C cg00086871 chr4:6988644 TBC1D14 0.95 7.98 0.4 2.46e-14 Granulocyte percentage of myeloid white cells; CRC cis rs6804368 0.649 rs1461069 chr3:30759900 T/C cg06106510 chr3:30762233 NA 0.42 7.6 0.39 3.13e-13 Blood metabolite levels; CRC cis rs13086611 1 rs13086611 chr3:49385417 A/T cg07274523 chr3:49395745 GPX1 0.46 6.3 0.33 9.47e-10 Educational attainment; CRC cis rs2739330 0.587 rs4820571 chr22:24242973 A/G cg10150615 chr22:24372951 LOC391322 -0.54 -7.83 -0.4 6.92e-14 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs9303280 0.776 rs9891174 chr17:38031802 T/A cg20243544 chr17:37824526 PNMT 0.37 5.68 0.3 2.89e-8 Self-reported allergy; CRC cis rs6502050 0.835 rs8073645 chr17:80110957 C/T cg09264619 chr17:80180166 NA -0.34 -5.81 -0.3 1.5e-8 Life satisfaction; CRC cis rs7843479 0.601 rs2306646 chr8:21846586 C/G cg17168535 chr8:21777572 XPO7 0.61 10.44 0.5 3.05e-22 Mean corpuscular volume; CRC trans rs9291683 0.566 rs13122689 chr4:10044648 A/G cg26043149 chr18:55253948 FECH 0.51 7.63 0.39 2.62e-13 Bone mineral density; CRC cis rs9894429 0.646 rs9904137 chr17:79613925 C/T cg13777783 chr17:79615861 NA -0.3 -5.73 -0.3 2.27e-8 Eye color traits; CRC cis rs10256972 0.567 rs7782651 chr7:1159895 T/G cg09177884 chr7:1199841 ZFAND2A -0.43 -6.03 -0.32 4.36e-9 Longevity;Endometriosis; CRC cis rs9467773 0.620 rs2494696 chr6:26620894 A/G cg09904177 chr6:26538194 HMGN4 0.71 11.06 0.52 2.17e-24 Intelligence (multi-trait analysis); CRC cis rs9491140 0.539 rs12529386 chr6:124678200 A/G cg22366943 chr6:124882293 NKAIN2 0.55 8.27 0.42 3.27e-15 Neuroticism; CRC trans rs113835537 0.627 rs4630309 chr11:66333072 A/C cg04130057 chr1:159895524 TAGLN2 0.57 6.13 0.32 2.5e-9 Airway imaging phenotypes; CRC cis rs17711722 0.727 rs2658585 chr7:65461941 A/T cg05627663 chr7:65219948 SNORA22;CCT6P1 0.5 7.38 0.38 1.32e-12 Calcium levels; CRC cis rs9903692 1.000 rs9903692 chr17:46273929 G/A cg21215337 chr17:46176117 CBX1 0.43 7.86 0.4 5.45e-14 Pulse pressure; CRC cis rs2495707 0.624 rs2489006 chr10:102419893 G/A cg24024056 chr10:102415556 NA -0.35 -7.0 -0.36 1.44e-11 Body mass index; CRC trans rs12517041 1.000 rs6452110 chr5:23299802 G/A ch.8.1293020R chr8:59333349 UBXN2B -0.55 -6.17 -0.32 2.05e-9 Calcium levels; CRC cis rs10463316 0.817 rs6877498 chr5:150802876 C/T cg03212797 chr5:150827313 SLC36A1 -0.47 -7.13 -0.37 6.27e-12 Metabolite levels (Pyroglutamine); CRC cis rs11758351 0.925 rs2183948 chr6:26180332 A/G cg01420254 chr6:26195488 NA 0.82 8.79 0.44 8.38e-17 Gout;Renal underexcretion gout; CRC cis rs6456156 0.586 rs13210649 chr6:167473193 T/G cg07741184 chr6:167504864 NA 0.38 6.8 0.35 4.95e-11 Primary biliary cholangitis; CRC cis rs1555895 0.599 rs997615 chr10:865214 A/G cg10556349 chr10:835070 NA -0.36 -7.12 -0.37 6.87e-12 Survival in rectal cancer; CRC cis rs9443645 0.527 rs7756996 chr6:79509367 A/C cg09184832 chr6:79620586 NA -0.45 -7.72 -0.39 1.43e-13 Intelligence (multi-trait analysis); CRC cis rs11148252 0.595 rs4884522 chr13:53053768 C/A cg20354231 chr13:53171401 NA -0.44 -7.13 -0.37 6.43e-12 Lewy body disease; CRC cis rs738322 0.967 rs133013 chr22:38570912 C/T cg17652424 chr22:38574118 PLA2G6 -0.22 -6.73 -0.35 7.71e-11 Cutaneous nevi; CRC cis rs2160860 0.736 rs7839885 chr8:39799238 G/A cg11363097 chr8:39792086 IDO2 -0.42 -7.27 -0.37 2.68e-12 Blood metabolite levels; CRC cis rs2404602 0.583 rs35707798 chr15:76565026 G/C cg23625390 chr15:77176239 SCAPER 0.39 5.62 0.3 4.02e-8 Blood metabolite levels; CRC cis rs2067615 0.965 rs4964484 chr12:107113024 A/C cg13491945 chr12:107078410 RFX4 -0.35 -5.9 -0.31 8.85e-9 Heart rate; CRC cis rs11098499 0.909 rs1809406 chr4:120377122 G/A cg09307838 chr4:120376055 NA 0.71 11.02 0.52 3.08e-24 Corneal astigmatism; CRC cis rs6582630 0.516 rs12814528 chr12:38296111 G/A cg13010199 chr12:38710504 ALG10B -0.4 -5.67 -0.3 3.19e-8 Drug-induced liver injury (flucloxacillin); CRC cis rs7552404 0.924 rs1498317 chr1:76171984 A/C cg22875332 chr1:76189707 ACADM 0.76 11.12 0.52 1.31e-24 Blood metabolite levels;Acylcarnitine levels; CRC cis rs6504622 0.818 rs758391 chr17:45017241 G/A cg16759221 chr17:45003025 GOSR2 -0.52 -7.83 -0.4 6.72e-14 Orofacial clefts; CRC cis rs2204008 0.837 rs2387317 chr12:38235319 T/C cg26384229 chr12:38710491 ALG10B 0.68 9.08 0.45 9.92e-18 Bladder cancer; CRC trans rs7395662 1.000 rs7483920 chr11:48599969 A/G cg21153622 chr11:89784906 NA -0.48 -7.74 -0.39 1.26e-13 HDL cholesterol; CRC cis rs2481665 0.510 rs2481676 chr1:62627675 C/T cg18591186 chr1:62594603 INADL -0.62 -9.49 -0.46 4.91e-19 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs12142240 0.698 rs72677600 chr1:46834449 G/A cg14993813 chr1:46806288 NSUN4 -0.5 -6.25 -0.33 1.26e-9 Menopause (age at onset); CRC cis rs6951245 1.000 rs113575110 chr7:1084394 G/A cg22907277 chr7:1156413 C7orf50 0.71 7.38 0.38 1.32e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs1005277 0.577 rs4934906 chr10:38015028 C/T cg00409905 chr10:38381863 ZNF37A -0.59 -9.61 -0.47 2.04e-19 Extrinsic epigenetic age acceleration; CRC cis rs853679 0.517 rs3823180 chr6:28061744 G/A cg25164649 chr6:28176230 NA 0.75 9.36 0.46 1.32e-18 Depression; CRC cis rs10512697 1.000 rs34469550 chr5:3571040 T/G cg19473799 chr5:3511975 NA -0.76 -5.86 -0.31 1.1e-8 Immune response to smallpox vaccine (IL-6); CRC cis rs3008870 0.583 rs11208985 chr1:67464666 G/A cg11518657 chr1:67396239 MIER1 -0.57 -6.07 -0.32 3.47e-9 Lymphocyte percentage of white cells; CRC cis rs68170813 0.559 rs76167266 chr7:106900664 C/T cg02696742 chr7:106810147 HBP1 -0.61 -6.7 -0.35 9.26e-11 Coronary artery disease; CRC cis rs938554 0.694 rs4697700 chr4:9945792 C/G cg00071950 chr4:10020882 SLC2A9 0.43 6.08 0.32 3.38e-9 Blood metabolite levels; CRC cis rs4713118 0.513 rs9368547 chr6:28028067 A/G cg12273811 chr6:28175739 NA 0.56 7.94 0.4 3.3e-14 Parkinson's disease; CRC trans rs1728785 1.000 rs12925177 chr16:68569645 A/G cg04657470 chr2:198365150 HSPE1;HSPD1 -0.58 -7.03 -0.36 1.17e-11 Ulcerative colitis; CRC cis rs881375 0.933 rs10818485 chr9:123667816 G/C cg14255062 chr9:123606675 PSMD5;LOC253039 0.42 6.06 0.32 3.7e-9 Rheumatoid arthritis; CRC cis rs7119 0.667 rs907390 chr15:77902419 T/C cg10437265 chr15:77819839 NA -0.47 -8.47 -0.42 8.41e-16 Type 2 diabetes; CRC cis rs539514 0.664 rs560069 chr13:76309344 A/G cg04757411 chr13:76259545 LMO7 0.36 6.01 0.31 5e-9 Type 1 diabetes; CRC cis rs9788721 0.836 rs11858836 chr15:78783277 G/A cg18825076 chr15:78729989 IREB2 -0.49 -7.19 -0.37 4.27e-12 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio;Emphysema imaging phenotypes;Emphysema distribution in smoking;Local histogram emphysema pattern;Post bronchodilator FEV1/FVC ratio in COPD; CRC cis rs6502050 0.835 rs7222057 chr17:80087647 C/A cg11859384 chr17:80120422 CCDC57 -0.37 -5.77 -0.3 1.85e-8 Life satisfaction; CRC cis rs1046896 0.553 rs3744160 chr17:80828303 G/A cg19046167 chr17:80928561 B3GNTL1 0.5 7.02 0.36 1.28e-11 Glycated hemoglobin levels; CRC cis rs7731657 0.537 rs9327578 chr5:130181064 C/T cg08523029 chr5:130500466 HINT1 -0.45 -5.84 -0.31 1.25e-8 Fasting plasma glucose; CRC cis rs2880765 0.805 rs11858817 chr15:86031260 C/T cg17133734 chr15:86042851 AKAP13 0.43 6.73 0.35 7.69e-11 Coronary artery disease; CRC cis rs9549367 0.756 rs2302756 chr13:113900197 G/A cg00898013 chr13:113819073 PROZ 0.44 6.52 0.34 2.63e-10 Platelet distribution width; CRC cis rs9894429 0.646 rs58398000 chr17:79576923 G/A cg13777783 chr17:79615861 NA 0.3 5.68 0.3 2.91e-8 Eye color traits; CRC cis rs9311474 0.508 rs6805156 chr3:52609362 T/C cg18404041 chr3:52824283 ITIH1 -0.4 -8.45 -0.42 9.79e-16 Electroencephalogram traits; CRC cis rs8060686 0.858 rs8057986 chr16:67893879 A/G cg26727032 chr16:67993705 SLC12A4 -0.71 -11.75 -0.54 7.2e-27 HDL cholesterol;Metabolic syndrome; CRC cis rs2739330 0.761 rs5760176 chr22:24402321 A/G cg23131131 chr22:24373011 LOC391322 0.49 7.41 0.38 1.09e-12 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs2658782 1.000 rs2658782 chr11:93166731 T/G cg21115391 chr11:93143810 CCDC67 -0.38 -5.63 -0.3 3.8e-8 Pulmonary function decline; CRC trans rs7267979 0.966 rs2227892 chr20:25264814 T/C cg17903999 chr18:56338584 MALT1 -0.41 -6.82 -0.35 4.4e-11 Liver enzyme levels (alkaline phosphatase); CRC cis rs2302729 0.578 rs7315556 chr12:2773855 G/A cg19945202 chr12:2788847 CACNA1C -0.49 -7.79 -0.39 9.09e-14 Sleep quality; CRC cis rs1008375 1.000 rs10805358 chr4:17652450 A/C cg04450456 chr4:17643702 FAM184B 0.41 6.58 0.34 1.88e-10 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs898097 0.812 rs7406011 chr17:80829980 C/T cg15369054 chr17:80825471 TBCD 0.53 8.53 0.43 5.55e-16 Breast cancer; CRC cis rs703842 0.616 rs4760332 chr12:58222672 A/C cg00677455 chr12:58241039 CTDSP2 -0.82 -11.95 -0.55 1.35e-27 Multiple sclerosis; CRC trans rs61931739 0.500 rs11053274 chr12:34547605 G/A cg26384229 chr12:38710491 ALG10B 0.68 8.89 0.44 4e-17 Morning vs. evening chronotype; CRC cis rs7589728 0.620 rs76687350 chr2:88473832 G/A cg07952391 chr2:88470173 THNSL2 0.62 6.19 0.32 1.8e-9 Plasma clusterin levels; CRC trans rs2303319 0.504 rs35304298 chr2:162617185 G/T cg20024234 chr21:43431083 ZNF295 -0.66 -5.96 -0.31 6.5e-9 Cognitive function; CRC cis rs6456156 0.792 rs10946212 chr6:167515947 C/G cg07513332 chr6:167530253 CCR6 0.37 6.07 0.32 3.52e-9 Primary biliary cholangitis; CRC cis rs2070488 1.000 rs34258593 chr3:38464565 T/C cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.91 16.84 0.68 2.62e-46 Electrocardiographic conduction measures; CRC cis rs13191362 1.000 rs66529337 chr6:163005662 G/A cg06582575 chr6:163149167 PACRG;PARK2 0.73 10.55 0.5 1.3e-22 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs875971 0.862 rs7786892 chr7:65628876 G/A cg00343986 chr7:65444356 GUSB -0.42 -6.0 -0.31 5.15e-9 Aortic root size; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg17371249 chr1:241682474 FH 0.43 5.97 0.31 6.26e-9 Response to antipsychotic treatment; CRC trans rs4650994 0.544 rs6682815 chr1:178501109 T/C cg05059571 chr16:84539110 KIAA1609 -0.62 -8.71 -0.43 1.53e-16 HDL cholesterol levels;HDL cholesterol; CRC cis rs2882667 0.658 rs288003 chr5:138231955 T/G cg09476006 chr5:138032270 NA 0.54 8.95 0.44 2.66e-17 Age-related hearing impairment (SNP x SNP interaction); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg01272601 chr2:69871685 AAK1 0.41 6.0 0.31 5.2e-9 Intelligence (multi-trait analysis); CRC cis rs801193 0.569 rs13226966 chr7:66233623 A/G cg12463550 chr7:65579703 CRCP 0.44 6.01 0.31 4.91e-9 Aortic root size; CRC cis rs7591163 1.000 rs4300818 chr2:228713255 G/T cg14646075 chr2:228736089 WDR69 -0.45 -6.14 -0.32 2.43e-9 Blood pressure; CRC cis rs7246657 0.943 rs4803229 chr19:37864682 T/G cg23950597 chr19:37808831 NA -0.47 -5.76 -0.3 1.94e-8 Coronary artery calcification; CRC cis rs11864453 0.713 rs7190995 chr16:72124157 A/G cg01557791 chr16:72042693 DHODH -0.44 -6.14 -0.32 2.36e-9 Fibrinogen levels; CRC cis rs13191362 0.507 rs2846519 chr6:163045463 G/A cg21926612 chr6:163149169 PACRG;PARK2 -0.62 -9.85 -0.48 3.09e-20 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs4253772 0.591 rs7286155 chr22:46714735 A/G cg24881330 chr22:46731750 TRMU 0.59 6.12 0.32 2.72e-9 LDL cholesterol;Cholesterol, total; CRC cis rs853679 0.517 rs4713152 chr6:28137454 G/A cg18032046 chr6:28092343 ZSCAN16 -0.51 -5.93 -0.31 7.47e-9 Depression; CRC cis rs7811142 1.000 rs11761725 chr7:100039815 C/T cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.15 16.13 0.66 1.55e-43 Platelet count; CRC cis rs7572644 0.664 rs12473340 chr2:28023797 G/A cg27432699 chr2:27873401 GPN1 0.45 5.63 0.3 3.85e-8 Response to carboplatin and paclitaxel in ovarian cancer (Caspase 3/7 EC50); CRC cis rs17270561 0.609 rs1317816 chr6:25765390 T/C cg17691542 chr6:26056736 HIST1H1C 0.64 8.14 0.41 8.02e-15 Iron status biomarkers; CRC cis rs35306767 0.855 rs11253468 chr10:903261 G/A cg20503657 chr10:835505 NA 0.86 10.94 0.52 5.88e-24 Eosinophil percentage of granulocytes; CRC cis rs6951245 0.872 rs75398423 chr7:1098414 T/G cg26224354 chr7:1096374 C7orf50;GPR146 -0.93 -12.05 -0.55 5.9e-28 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs3857067 1.000 rs1397025 chr4:95018987 G/T cg11021082 chr4:95130006 SMARCAD1 -0.4 -6.05 -0.32 3.9e-9 QT interval; CRC cis rs10256972 0.567 rs2960835 chr7:1202963 A/G cg27094323 chr7:1216898 NA -0.37 -6.04 -0.32 4.18e-9 Longevity;Endometriosis; CRC cis rs7119 0.717 rs11636529 chr15:77816220 T/C cg27398640 chr15:77910606 LINGO1 -0.43 -7.47 -0.38 7.13e-13 Type 2 diabetes; CRC cis rs8062405 0.755 rs7186573 chr16:28587389 T/C cg16576597 chr16:28551801 NUPR1 0.55 8.12 0.41 9.39e-15 Cognitive ability (multi-trait analysis);Cognitive ability; CRC cis rs9818758 0.607 rs9847839 chr3:49289003 T/C cg07636037 chr3:49044803 WDR6 -0.7 -6.14 -0.32 2.36e-9 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; CRC cis rs10128264 0.902 rs1250584 chr10:80976442 G/T cg20744163 chr10:80999841 ZMIZ1 -0.42 -7.2 -0.37 3.99e-12 Response to methotrexate in juvenile idiopathic arthritis; CRC trans rs75804782 0.581 rs3191996 chr2:239344412 A/G cg01134436 chr17:81009848 B3GNTL1 -0.74 -7.15 -0.37 5.77e-12 Morning vs. evening chronotype;Chronotype; CRC cis rs55788414 0.932 rs59201365 chr16:81185681 C/G cg06400318 chr16:81190750 PKD1L2 -0.58 -6.63 -0.34 1.38e-10 Left ventricular obstructive tract defect (maternal effect); CRC cis rs11212617 0.935 rs227064 chr11:108207393 T/C cg12106634 chr11:108092400 ATM;NPAT 0.41 5.91 0.31 8.77e-9 Response to metformin in type 2 diabetes (glycemic); CRC cis rs66573146 0.656 rs66905212 chr4:6949508 G/C cg26116260 chr4:7069785 GRPEL1 -0.68 -5.92 -0.31 8.18e-9 Granulocyte percentage of myeloid white cells; CRC cis rs3858526 0.584 rs10769274 chr11:5866925 T/C cg05234568 chr11:5960015 NA -0.65 -9.31 -0.46 1.87e-18 DNA methylation (variation); CRC cis rs9303401 1.000 rs7218362 chr17:56888299 A/G cg10487724 chr17:56770010 TEX14;RAD51C 0.56 8.28 0.42 3.11e-15 Cognitive test performance; CRC cis rs2839186 0.508 rs6518278 chr21:47640571 A/G cg09417038 chr21:47716443 C21orf57 0.5 8.02 0.4 1.9e-14 Testicular germ cell tumor; CRC cis rs13256369 1.000 rs873063 chr8:8572447 A/G cg18904891 chr8:8559673 CLDN23 0.48 6.36 0.33 6.66e-10 Obesity-related traits; CRC cis rs28655083 0.828 rs7404322 chr16:77130003 G/A cg01753188 chr16:77233325 SYCE1L;MON1B 0.61 8.56 0.43 4.33e-16 Lobe attachment (rater-scored or self-reported); CRC trans rs8135828 1.000 rs11704899 chr22:29918482 C/T cg05402634 chr11:70644141 SHANK2 0.56 6.2 0.32 1.71e-9 Lipid traits; CRC cis rs6496667 0.779 rs10083670 chr15:91022135 C/T cg04176472 chr15:90893244 GABARAPL3 0.51 7.32 0.37 1.9e-12 Rheumatoid arthritis; CRC cis rs6546550 0.935 rs13392884 chr2:70036711 A/G cg02498382 chr2:70120550 SNRNP27 -0.46 -7.61 -0.39 2.97e-13 Prevalent atrial fibrillation; CRC cis rs4481887 0.676 rs1538704 chr1:248523554 C/T cg26353448 chr1:248524236 OR2T4 -0.33 -6.86 -0.35 3.51e-11 Common traits (Other); CRC cis rs523522 0.962 rs4766966 chr12:120942911 G/C cg27279351 chr12:120934652 DYNLL1 0.75 11.24 0.53 5.11e-25 High light scatter reticulocyte count; CRC cis rs12681287 0.547 rs56752411 chr8:87515156 C/T cg27223183 chr8:87520930 FAM82B -0.53 -7.46 -0.38 7.85e-13 Caudate activity during reward; CRC cis rs4713118 0.955 rs34752872 chr6:27683244 A/T cg20933634 chr6:27740509 NA 0.56 7.74 0.39 1.26e-13 Parkinson's disease; CRC cis rs7618915 0.547 rs10865973 chr3:52718154 A/T cg10802521 chr3:52805072 NEK4 -0.58 -8.85 -0.44 5.34e-17 Bipolar disorder; CRC trans rs4843747 0.671 rs8062855 chr16:88106941 T/C cg26811252 chr16:29126840 RRN3P2 0.61 8.31 0.42 2.62e-15 Menopause (age at onset); CRC cis rs4862750 0.881 rs6813866 chr4:187872161 T/G cg06074448 chr4:187884817 NA -0.6 -10.89 -0.51 8.5e-24 Lobe attachment (rater-scored or self-reported); CRC cis rs2797160 0.967 rs926854 chr6:126021780 A/G cg05901451 chr6:126070800 HEY2 0.4 6.15 0.32 2.27e-9 Endometrial cancer; CRC cis rs780096 0.506 rs1728922 chr2:27644464 A/C cg27432699 chr2:27873401 GPN1 -0.5 -7.6 -0.39 3.06e-13 Total body bone mineral density; CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg23325670 chr19:17337031 OCEL1 0.37 6.01 0.31 4.9e-9 Obesity-related traits; CRC cis rs12586317 0.547 rs10146699 chr14:35483577 G/A cg16230307 chr14:35515116 FAM177A1 0.87 10.25 0.49 1.43e-21 Psoriasis; CRC cis rs11677416 1.000 rs7570215 chr2:113527660 G/T cg27083787 chr2:113543245 IL1A 0.45 6.47 0.34 3.5e-10 Response to antipsychotic treatment in schizophrenia (working memory); CRC cis rs9583531 0.891 rs7999536 chr13:111382199 G/A cg24331049 chr13:111365604 ING1 0.51 5.62 0.3 3.99e-8 Coronary artery disease; CRC cis rs10504229 0.596 rs7004566 chr8:58115602 G/C cg22535103 chr8:58192502 C8orf71 -0.7 -9.34 -0.46 1.47e-18 Developmental language disorder (linguistic errors); CRC cis rs9326248 1.000 rs664082 chr11:117071070 C/G cg10398005 chr11:117014888 PAFAH1B2 -0.4 -5.66 -0.3 3.33e-8 Blood protein levels; CRC cis rs2120019 0.938 rs5020842 chr15:75322310 T/C cg17294928 chr15:75287854 SCAMP5 -0.77 -11.24 -0.53 5.06e-25 Blood trace element (Zn levels); CRC cis rs1008375 0.932 rs964012 chr4:17619184 A/G cg16339924 chr4:17578868 LAP3 0.52 6.62 0.34 1.45e-10 Parasitemia in Tripanosoma cruzi seropositivity; CRC trans rs2303319 0.504 rs62189041 chr2:162599506 T/C cg22902534 chr3:183892754 AP2M1 -0.7 -6.1 -0.32 2.96e-9 Cognitive function; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg03986968 chr15:34330894 AVEN;CHRM5 0.4 6.23 0.32 1.43e-9 Liver disease severity in Alagille syndrome; CRC cis rs3091242 0.809 rs660129 chr1:25727438 C/T cg20684491 chr1:25596433 NA 0.4 6.84 0.35 3.82e-11 Erythrocyte sedimentation rate; CRC cis rs6582630 0.537 rs6582500 chr12:38534206 G/A cg13010199 chr12:38710504 ALG10B 0.47 5.99 0.31 5.65e-9 Drug-induced liver injury (flucloxacillin); CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg05065690 chr12:49246007 DDX23 0.51 6.64 0.34 1.28e-10 Thyroid stimulating hormone; CRC trans rs1656966 1.000 rs1656966 chr3:186466252 C/T cg07721005 chr5:87564621 TMEM161B 0.39 5.98 0.31 5.86e-9 Myopia (pathological); CRC cis rs4664293 0.647 rs6756502 chr2:160554583 T/G cg08347373 chr2:160653686 CD302 0.39 6.61 0.34 1.58e-10 Monocyte percentage of white cells; CRC cis rs11030122 0.661 rs963998 chr11:4062803 A/G cg18678763 chr11:4115507 RRM1 -0.5 -7.92 -0.4 3.63e-14 Mean platelet volume;Platelet distribution width; CRC cis rs11098499 0.535 rs7671759 chr4:120248094 A/C cg09307838 chr4:120376055 NA 0.62 9.53 0.47 3.63e-19 Corneal astigmatism; CRC cis rs2797160 1.000 rs2797160 chr6:126010116 A/G cg05901451 chr6:126070800 HEY2 0.4 6.2 0.32 1.65e-9 Endometrial cancer; CRC cis rs13108904 0.650 rs3796618 chr4:1349602 T/A cg19318889 chr4:1322082 MAEA 0.44 6.58 0.34 1.81e-10 Obesity-related traits; CRC cis rs9902453 1.000 rs62070270 chr17:28263980 A/G cg26525008 chr17:28256777 EFCAB5;SSH2 0.62 9.64 0.47 1.56e-19 Coffee consumption (cups per day); CRC cis rs1577917 0.560 rs9450288 chr6:86221586 A/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A 0.44 6.01 0.31 4.94e-9 Response to antipsychotic treatment; CRC cis rs8105895 0.935 rs62111027 chr19:22269019 T/C cg02657401 chr19:22469223 NA -0.37 -5.73 -0.3 2.32e-8 Body mass index (change over time); CRC cis rs4972806 0.814 rs6710370 chr2:177045969 T/C cg25347419 chr2:177043501 NA 0.58 9.04 0.45 1.41e-17 IgG glycosylation; CRC cis rs6752107 0.503 rs2304774 chr2:234235749 G/C cg07618928 chr2:234183455 ATG16L1;SCARNA5 0.5 7.56 0.38 4.03e-13 Crohn's disease;Inflammatory bowel disease; CRC cis rs1577917 0.958 rs34230196 chr6:86526022 T/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.49 -6.58 -0.34 1.82e-10 Response to antipsychotic treatment; CRC cis rs9399137 0.507 rs4896128 chr6:135349756 A/G cg24558204 chr6:135376177 HBS1L -0.65 -9.89 -0.48 2.36e-20 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; CRC cis rs4664293 0.647 rs7562850 chr2:160441534 G/A cg08347373 chr2:160653686 CD302 -0.38 -6.48 -0.34 3.42e-10 Monocyte percentage of white cells; CRC cis rs17711722 0.740 rs7809991 chr7:65406218 A/G cg18876405 chr7:65276391 NA 0.66 12.13 0.56 3.09e-28 Calcium levels; CRC cis rs9309473 0.950 rs17009149 chr2:73790368 T/C cg20560298 chr2:73613845 ALMS1 -0.48 -5.87 -0.31 1.08e-8 Metabolite levels; CRC cis rs1559088 0.847 rs3786933 chr19:33602881 C/T cg27124370 chr19:33622961 WDR88 0.44 6.12 0.32 2.64e-9 Bone ultrasound measurement (broadband ultrasound attenuation); CRC cis rs2286885 1.000 rs741025 chr9:129251792 C/T cg15282417 chr9:129245246 FAM125B 0.46 8.69 0.43 1.75e-16 Intraocular pressure; CRC cis rs9326248 1.000 rs664922 chr11:117070895 C/A cg15534755 chr11:117069859 TAGLN 0.35 6.74 0.35 6.96e-11 Blood protein levels; CRC cis rs1712517 0.787 rs1163089 chr10:105043964 G/A cg05636881 chr10:105038444 INA 0.48 8.12 0.41 9.61e-15 Migraine; CRC cis rs9916302 0.861 rs4795377 chr17:37669056 C/T cg00129232 chr17:37814104 STARD3 -0.54 -8.18 -0.41 6.31e-15 Glomerular filtration rate (creatinine); CRC cis rs780096 0.546 rs4665976 chr2:27640325 A/G cg12000995 chr2:27665139 KRTCAP3 -0.31 -6.47 -0.34 3.66e-10 Total body bone mineral density; CRC cis rs9462846 0.853 rs7740252 chr6:42871045 T/C cg21280719 chr6:42927975 GNMT -0.33 -6.47 -0.34 3.65e-10 Blood protein levels; CRC cis rs2982552 0.967 rs2982556 chr6:152056842 G/A cg22157087 chr6:152012887 ESR1 0.4 6.24 0.33 1.36e-9 Bone properties (heel); CRC cis rs887829 0.570 rs13002774 chr2:234593706 G/A cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.48 -7.53 -0.38 5.08e-13 Metabolic traits;Bilirubin levels;Cholelithiasis-related traits in sickle cell anemia;Metabolite levels;Total bilirubin levels in HIV-1 infection;Serum metabolite levels;Blood metabolite levels; CRC cis rs769267 0.895 rs2965183 chr19:19545696 G/A cg03709012 chr19:19516395 GATAD2A 0.74 11.63 0.54 2.05e-26 Tonsillectomy; CRC cis rs4563143 0.647 rs34218744 chr19:29256821 A/T cg03161606 chr19:29218774 NA 0.53 6.62 0.34 1.49e-10 Methadone dose in opioid dependence; CRC cis rs7666738 0.830 rs62321587 chr4:98997958 T/C cg17366294 chr4:99064904 C4orf37 0.44 7.39 0.38 1.19e-12 Colonoscopy-negative controls vs population controls; CRC cis rs990171 0.913 rs4851009 chr2:103055644 G/A cg03938978 chr2:103052716 IL18RAP 0.46 5.91 0.31 8.41e-9 Lymphocyte counts; CRC cis rs12143943 0.966 rs6669246 chr1:204557561 A/G cg17419461 chr1:204415978 PIK3C2B 0.41 6.35 0.33 7.3e-10 Cognitive performance; CRC cis rs2281845 0.507 rs12025414 chr1:201100496 A/G cg22815214 chr1:201083145 CACNA1S 0.51 6.39 0.33 5.64e-10 Permanent tooth development; CRC cis rs1552244 1.000 rs66838678 chr3:10150350 G/A cg13047869 chr3:10149882 C3orf24 0.57 7.73 0.39 1.34e-13 Alzheimer's disease; CRC cis rs10751667 1.000 rs10751667 chr11:941941 A/T cg23136738 chr11:925521 AP2A2 -0.5 -7.97 -0.4 2.56e-14 Alzheimer's disease (late onset); CRC cis rs514406 0.505 rs269292 chr1:53187911 T/C cg25767906 chr1:53392781 SCP2 -0.38 -5.93 -0.31 7.8e-9 Monocyte count; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg04677470 chr13:22247804 FGF9 0.52 6.63 0.34 1.4e-10 Thyroid stimulating hormone; CRC cis rs939584 1.000 rs10173167 chr2:646767 G/A cg03610516 chr2:642275 NA 0.42 5.88 0.31 9.94e-9 Body mass index; CRC cis rs477895 0.713 rs12787852 chr11:63954648 G/A cg23719950 chr11:63933701 MACROD1 -0.67 -8.58 -0.43 3.92e-16 Mean platelet volume; CRC trans rs9747201 0.962 rs34016823 chr17:80095428 G/T cg07393940 chr7:158741817 NA -0.51 -7.38 -0.38 1.27e-12 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs6570726 0.791 rs387376 chr6:145822565 T/C cg13319975 chr6:146136371 FBXO30 -0.44 -6.66 -0.34 1.13e-10 Lobe attachment (rater-scored or self-reported); CRC cis rs7618915 0.570 rs2336145 chr3:52629750 A/C cg15147215 chr3:52552868 STAB1 -0.62 -10.18 -0.49 2.42e-21 Bipolar disorder; CRC cis rs10256972 0.706 rs4285396 chr7:1123738 A/G cg03188948 chr7:1209495 NA 0.44 6.18 0.32 1.85e-9 Longevity;Endometriosis; CRC cis rs7927592 0.830 rs7120635 chr11:68261293 A/G cg16797656 chr11:68205561 LRP5 0.41 7.04 0.36 1.12e-11 Total body bone mineral density; CRC cis rs875971 0.642 rs35526611 chr7:66094008 C/T cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.43 -6.4 -0.33 5.23e-10 Aortic root size; CRC cis rs1218582 0.772 rs7528532 chr1:154874440 C/T cg16680214 chr1:154839983 KCNN3 -0.45 -8.95 -0.44 2.64e-17 Prostate cancer; CRC trans rs7647973 0.593 rs55997059 chr3:49858661 A/T cg21665057 chr3:196295764 WDR53;FBXO45 0.69 8.06 0.41 1.38e-14 Menarche (age at onset); CRC cis rs7727544 0.904 rs58835386 chr5:131600559 A/G cg11843238 chr5:131593191 PDLIM4 0.33 6.37 0.33 6.51e-10 Blood metabolite levels; CRC cis rs5769765 0.542 rs5769751 chr22:50242733 T/G cg08270630 chr22:50330655 NA 0.67 6.36 0.33 6.78e-10 Schizophrenia; CRC cis rs769267 0.965 rs2074550 chr19:19387743 A/C cg02546618 chr19:19431379 KIAA0892;SF4 0.44 6.06 0.32 3.73e-9 Tonsillectomy; CRC cis rs9649465 0.967 rs7809453 chr7:123301940 A/G cg03229431 chr7:123269106 ASB15 -0.37 -5.69 -0.3 2.82e-8 Migraine; CRC trans rs11764590 0.694 rs6977161 chr7:2099361 T/C cg11693508 chr17:37793320 STARD3 0.48 6.44 0.33 4.14e-10 Neuroticism; CRC cis rs10504229 1.000 rs56344560 chr8:58180626 C/G cg05313129 chr8:58192883 C8orf71 -0.46 -6.83 -0.35 4.16e-11 Developmental language disorder (linguistic errors); CRC cis rs1552244 1.000 rs6789156 chr3:10124120 C/T cg18598329 chr3:10140678 FANCD2;C3orf24 -0.88 -11.92 -0.55 1.82e-27 Alzheimer's disease; CRC cis rs3996993 0.702 rs6458871 chr6:52665977 C/T cg20803780 chr6:52668592 GSTA1 -0.37 -6.86 -0.35 3.44e-11 Hemoglobin concentration; CRC cis rs3204270 0.639 rs7215738 chr17:79659847 C/T cg09655341 chr17:79618100 PDE6G 0.57 6.83 0.35 4.23e-11 Dental caries; CRC cis rs4819052 0.840 rs914217 chr21:46698299 A/G cg19498844 chr21:46707878 POFUT2;LOC642852 0.84 10.8 0.51 1.83e-23 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs3857067 0.806 rs1876918 chr4:95099424 G/A cg11021082 chr4:95130006 SMARCAD1 -0.49 -7.65 -0.39 2.22e-13 QT interval; CRC trans rs1814175 0.817 rs1996982 chr11:49972619 G/T cg21153622 chr11:89784906 NA -0.37 -5.97 -0.31 6.05e-9 Height; CRC cis rs10751667 1.000 rs12798036 chr11:947585 T/C cg01483505 chr11:975446 AP2A2 0.39 5.98 0.31 5.75e-9 Alzheimer's disease (late onset); CRC cis rs9372498 0.536 rs9489428 chr6:118852935 T/C cg01339444 chr6:118972232 C6orf204 0.53 6.0 0.31 5.22e-9 Diastolic blood pressure; CRC cis rs9916302 0.768 rs62077464 chr17:37656056 C/G cg15445000 chr17:37608096 MED1 0.4 8.62 0.43 2.78e-16 Glomerular filtration rate (creatinine); CRC cis rs1005277 0.602 rs2504142 chr10:38383793 C/T cg25427524 chr10:38739819 LOC399744 -0.77 -13.64 -0.6 6.68e-34 Extrinsic epigenetic age acceleration; CRC cis rs9309473 0.948 rs10173534 chr2:73813432 C/T cg20560298 chr2:73613845 ALMS1 -0.48 -5.84 -0.31 1.26e-8 Metabolite levels; CRC cis rs7552404 1.000 rs4949879 chr1:76237143 G/A cg03433033 chr1:76189801 ACADM 0.77 10.51 0.5 1.75e-22 Blood metabolite levels;Acylcarnitine levels; CRC cis rs7618501 0.602 rs2624853 chr3:50128893 A/G cg24308560 chr3:49941425 MST1R 0.5 8.23 0.41 4.39e-15 Intelligence (multi-trait analysis); CRC cis rs68170813 0.559 rs79543528 chr7:106891090 C/T cg02696742 chr7:106810147 HBP1 -0.6 -6.65 -0.34 1.25e-10 Coronary artery disease; CRC cis rs4901869 0.932 rs12878445 chr14:59339361 A/G cg02291164 chr14:59296302 NA 0.36 6.67 0.35 1.09e-10 Panic disorder; CRC cis rs9648716 1.000 rs17161762 chr7:140589208 C/T cg10747023 chr7:140774559 NA 0.44 5.81 0.31 1.46e-8 Type 2 diabetes; CRC cis rs6502050 0.835 rs4523985 chr17:80154466 C/A cg22110888 chr17:80059540 CCDC57 0.38 5.93 0.31 7.53e-9 Life satisfaction; CRC cis rs6429082 0.509 rs2246554 chr1:235520176 A/G cg26050004 chr1:235667680 B3GALNT2 0.46 6.72 0.35 8.12e-11 Adiposity; CRC cis rs2153535 0.580 rs6941771 chr6:8494452 T/G cg21535247 chr6:8435926 SLC35B3 0.49 7.44 0.38 8.86e-13 Motion sickness; CRC cis rs77956314 0.515 rs7302025 chr12:117442902 C/T cg02017074 chr12:117425053 FBXW8 0.62 7.98 0.4 2.45e-14 Subcortical brain region volumes;Hippocampal volume; CRC cis rs910187 0.678 rs6122564 chr20:45814745 A/C cg27589058 chr20:45804311 EYA2 -0.38 -7.27 -0.37 2.7e-12 Migraine; CRC cis rs7412746 0.658 rs3768015 chr1:150812954 C/T cg18016565 chr1:150552671 MCL1 0.45 6.28 0.33 1.05e-9 Melanoma; CRC cis rs3924048 0.574 rs12096486 chr1:12616911 T/C cg00291366 chr1:12616550 NA 0.6 10.78 0.51 2.11e-23 Optic cup area; CRC cis rs4319547 0.619 rs7973869 chr12:122874284 G/C cg23029597 chr12:123009494 RSRC2 -0.56 -6.88 -0.35 2.96e-11 Body mass index; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg01784859 chr1:160001849 PIGM 0.51 7.15 0.37 5.65e-12 Response to antipsychotic treatment; CRC cis rs11148252 0.538 rs2408611 chr13:52709742 C/T cg00495681 chr13:53174319 NA 0.61 9.03 0.45 1.45e-17 Lewy body disease; CRC cis rs6062302 0.522 rs3810492 chr20:62219740 G/A cg06363034 chr20:62225388 GMEB2 -0.44 -6.8 -0.35 5.06e-11 Glioblastoma; CRC cis rs1707322 0.721 rs10430124 chr1:46221617 C/T cg03146154 chr1:46216737 IPP 0.68 9.61 0.47 2.02e-19 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs7173389 0.551 rs77883904 chr15:73678498 C/A cg01796676 chr15:73680284 NA 0.59 5.84 0.31 1.28e-8 Resting heart rate; CRC cis rs8062405 0.755 rs55792032 chr16:28599411 A/G cg05139728 chr16:28306816 SBK1 -0.38 -6.23 -0.32 1.41e-9 Cognitive ability (multi-trait analysis);Cognitive ability; CRC cis rs9837602 0.882 rs9875664 chr3:99729130 C/T cg07805332 chr3:99536008 MIR548G;C3orf26 -0.5 -6.72 -0.35 8.04e-11 Breast cancer; CRC trans rs2012709 0.935 rs34666745 chr5:32552432 G/A cg03755955 chr8:6424269 MCPH1 0.45 6.63 0.34 1.39e-10 Breast cancer; CRC cis rs25422 0.938 rs114309775 chr6:118838782 G/A cg15382696 chr6:118971807 C6orf204 0.62 8.05 0.41 1.5e-14 Renal cell carcinoma; CRC cis rs7901135 0.924 rs7099432 chr10:60559615 G/A cg23799393 chr10:60588674 BICC1 0.39 6.0 0.31 5.27e-9 Morning vs. evening chronotype; CRC cis rs7605827 0.930 rs12692264 chr2:15539229 T/A cg19274914 chr2:15703543 NA 0.4 5.92 0.31 8.18e-9 Educational attainment (years of education); CRC cis rs12580194 0.593 rs58254871 chr12:55750281 G/A cg19537932 chr12:55886519 OR6C68 -0.71 -9.12 -0.45 7.79e-18 Cancer; CRC cis rs873946 0.517 rs2803990 chr10:134560340 A/G cg26818010 chr10:134567672 INPP5A -0.54 -7.72 -0.39 1.42e-13 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CRC cis rs7833986 0.501 rs72653957 chr8:56990048 G/A cg23139584 chr8:56987506 RPS20;SNORD54 0.91 12.38 0.56 3.75e-29 Height; CRC trans rs3942852 0.774 rs10838814 chr11:48187178 G/A cg03929089 chr4:120376271 NA -0.72 -9.04 -0.45 1.42e-17 Acute lymphoblastic leukemia (childhood); CRC cis rs9527 0.615 rs10883811 chr10:104727279 A/G cg15744005 chr10:104629667 AS3MT -0.31 -6.22 -0.32 1.54e-9 Arsenic metabolism; CRC trans rs7395662 0.890 rs1847652 chr11:48975013 A/G cg21153622 chr11:89784906 NA 0.45 7.1 0.36 7.58e-12 HDL cholesterol; CRC cis rs853679 0.517 rs9393895 chr6:28127621 T/C cg06470822 chr6:28175283 NA 1.01 13.37 0.59 7.38e-33 Depression; CRC cis rs7131987 0.903 rs2194520 chr12:29423712 C/T cg09582351 chr12:29534625 ERGIC2 -0.28 -6.03 -0.32 4.41e-9 QT interval; CRC cis rs2882667 0.898 rs2882792 chr5:138380480 G/T cg04439458 chr5:138467593 SIL1 -0.33 -5.98 -0.31 5.93e-9 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs10256972 0.713 rs10435026 chr7:1065948 A/G cg07308232 chr7:1071921 C7orf50 -0.48 -6.54 -0.34 2.31e-10 Longevity;Endometriosis; CRC trans rs1455244 0.700 rs7229302 chr18:11508904 G/T cg17876050 chr2:170655740 SSB 0.38 6.07 0.32 3.5e-9 Schizophrenia; CRC trans rs12660387 1.000 rs62415794 chr6:65267623 T/C cg13393512 chr9:135749454 C9orf98 0.51 5.96 0.31 6.5e-9 Schizophrenia; CRC cis rs13191362 1.000 rs66594243 chr6:163169024 T/C cg06582575 chr6:163149167 PACRG;PARK2 0.92 11.56 0.54 3.54e-26 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs34311866 0.577 rs11736181 chr4:877412 C/T cg07828340 chr4:882639 GAK 0.59 5.95 0.31 6.98e-9 Parkinson's disease; CRC cis rs739401 0.967 rs451041 chr11:3060725 C/T cg08508325 chr11:3079039 CARS -0.38 -6.82 -0.35 4.5e-11 Longevity; CRC cis rs798554 0.644 rs7783400 chr7:2894434 A/C cg19346786 chr7:2764209 NA 0.33 5.76 0.3 1.98e-8 Height; CRC cis rs10927875 0.722 rs1763605 chr1:16338925 T/G cg24140574 chr1:16342155 HSPB7 0.43 5.74 0.3 2.11e-8 Dilated cardiomyopathy; CRC cis rs17739167 0.550 rs4924589 chr15:42229632 C/T cg20935245 chr15:42234343 EHD4 0.42 6.7 0.35 8.95e-11 Monocyte count; CRC cis rs847577 0.715 rs12665986 chr7:97719676 A/G cg21770322 chr7:97807741 LMTK2 -0.74 -13.87 -0.61 9.53e-35 Breast cancer; CRC cis rs6687430 0.562 rs6676491 chr1:10633421 A/C cg17425144 chr1:10567563 PEX14 0.47 9.41 0.46 8.87e-19 Hand grip strength; CRC cis rs13323323 0.691 rs9815769 chr3:44663014 A/T cg14768256 chr3:44754587 ZNF502 -0.49 -6.22 -0.32 1.52e-9 IgG glycosylation; CRC cis rs1320333 0.772 rs17786111 chr2:700562 C/T cg20966539 chr2:681320 NA 0.62 6.09 0.32 3.2e-9 Obesity-related traits; CRC cis rs10463316 0.862 rs10062928 chr5:150768355 C/T cg03212797 chr5:150827313 SLC36A1 -0.5 -7.92 -0.4 3.67e-14 Metabolite levels (Pyroglutamine); CRC trans rs875971 0.660 rs2191268 chr7:66110224 C/T cg13596910 chr17:42254336 C17orf65;ASB16 0.36 6.07 0.32 3.47e-9 Aortic root size; CRC cis rs8067545 0.750 rs7208365 chr17:19998017 T/G cg13482628 chr17:19912719 NA 0.44 7.06 0.36 1.01e-11 Schizophrenia; CRC trans rs10504229 0.953 rs75545548 chr8:58172816 T/C cg04077850 chr5:125800366 GRAMD3 0.37 6.27 0.33 1.15e-9 Developmental language disorder (linguistic errors); CRC cis rs2836974 0.897 rs35386515 chr21:40532047 C/T cg17971929 chr21:40555470 PSMG1 0.81 11.89 0.55 2.36e-27 Cognitive function; CRC cis rs10504229 1.000 rs68076606 chr8:58191271 A/G cg01721255 chr8:58191610 C8orf71 0.49 6.17 0.32 2e-9 Developmental language disorder (linguistic errors); CRC trans rs6703335 0.870 rs10803142 chr1:243598234 A/G cg03383713 chr16:771506 FAM173A 0.43 6.04 0.32 4.08e-9 Schizophrenia;Schizophrenia, schizoaffective disorder or bipolar disorder; CRC cis rs11997175 0.646 rs4612298 chr8:33713451 G/A ch.8.33884649F chr8:33765107 NA 0.45 6.55 0.34 2.26e-10 Body mass index; CRC cis rs9733 0.596 rs12063547 chr1:150674053 G/T cg18016565 chr1:150552671 MCL1 -0.42 -6.14 -0.32 2.32e-9 Tonsillectomy; CRC cis rs796364 1.000 rs10178177 chr2:200829993 G/A cg23649088 chr2:200775458 C2orf69 0.53 5.73 0.3 2.31e-8 Schizophrenia; CRC cis rs11043280 0.703 rs11043275 chr12:122402723 T/C cg21171335 chr12:122356390 WDR66 0.36 5.63 0.3 3.83e-8 Mean platelet volume; CRC cis rs28386778 0.897 rs4968662 chr17:61834537 A/G cg11494091 chr17:61959527 GH2 0.6 10.28 0.49 1.13e-21 Prudent dietary pattern; CRC cis rs798554 0.718 rs1636247 chr7:2881917 A/G cg19346786 chr7:2764209 NA -0.41 -6.85 -0.35 3.73e-11 Height; CRC trans rs6951245 1.000 rs113066613 chr7:1094128 T/C cg13565492 chr6:43139072 SRF -0.72 -7.46 -0.38 7.73e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs7772486 0.727 rs10447449 chr6:146138707 A/G cg05347473 chr6:146136440 FBXO30 0.37 5.72 0.3 2.39e-8 Lobe attachment (rater-scored or self-reported); CRC cis rs2153535 0.547 rs9505475 chr6:8542890 A/G cg07606381 chr6:8435919 SLC35B3 0.67 11.11 0.52 1.5e-24 Motion sickness; CRC cis rs6499255 0.951 rs7200935 chr16:69564497 T/C cg15192750 chr16:69999425 NA 0.51 6.85 0.35 3.66e-11 IgE levels; CRC cis rs6951245 0.935 rs11766669 chr7:1063593 C/T cg21664854 chr7:1097933 C7orf50;GPR146 0.77 8.66 0.43 2.16e-16 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC trans rs4657015 1.000 rs4657015 chr1:161272441 A/G cg18430411 chr8:144873183 SCRIB -0.49 -9.01 -0.44 1.69e-17 Visceral adipose tissue adjusted for BMI; CRC cis rs73195822 0.614 rs55946973 chr12:111214936 C/T cg12870014 chr12:110450643 ANKRD13A 0.67 7.46 0.38 8e-13 Itch intensity from mosquito bite; CRC cis rs59918340 0.728 rs35257077 chr8:142235049 C/T cg23750338 chr8:142222470 SLC45A4 -0.6 -10.61 -0.51 8e-23 Immature fraction of reticulocytes; CRC cis rs7680126 0.633 rs11730631 chr4:10292968 C/T cg00071950 chr4:10020882 SLC2A9 0.45 5.99 0.31 5.56e-9 Urate levels in lean individuals;Urate levels in overweight individuals;Urate levels in obese individuals; CRC cis rs910187 0.605 rs8124995 chr20:45811788 G/T cg27589058 chr20:45804311 EYA2 -0.41 -7.7 -0.39 1.5700000000000001e-13 Migraine; CRC cis rs6840360 0.615 rs1561917 chr4:152479233 G/A cg09659197 chr4:152720779 NA 0.31 5.64 0.3 3.6e-8 Intelligence (multi-trait analysis); CRC cis rs6496667 0.779 rs8041401 chr15:90958545 A/G cg04176472 chr15:90893244 GABARAPL3 0.6 7.83 0.4 6.92e-14 Rheumatoid arthritis; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg14460003 chr20:31173015 NA 0.36 6.53 0.34 2.43e-10 Liver disease severity in Alagille syndrome; CRC cis rs7224737 0.956 rs8081327 chr17:40274200 G/A cg20291162 chr17:40259547 DHX58 -0.55 -7.91 -0.4 4e-14 Fibrinogen levels; CRC cis rs9322193 0.962 rs11155685 chr6:150102785 A/C cg07701084 chr6:150067640 NUP43 0.47 6.61 0.34 1.51e-10 Lung cancer; CRC cis rs1799949 0.965 rs7212284 chr17:41205941 A/G cg25072359 chr17:41440525 NA 0.5 7.97 0.4 2.62e-14 Menopause (age at onset); CRC cis rs4285028 0.898 rs73855476 chr3:121633412 A/G cg20356878 chr3:121714668 ILDR1 -0.45 -6.5 -0.34 2.95e-10 Multiple sclerosis; CRC trans rs7615952 0.932 rs7630077 chr3:125649676 T/C cg21747405 chr11:67723411 NA -0.43 -6.13 -0.32 2.45e-9 Blood pressure (smoking interaction); CRC cis rs2154427 1.000 rs2833962 chr21:34174289 A/G cg16417831 chr21:33958411 TCP10L 0.47 5.92 0.31 8.31e-9 Bilirubin levels; CRC cis rs7618501 0.699 rs2681781 chr3:49898273 A/G cg24110177 chr3:50126178 RBM5 -0.45 -6.59 -0.34 1.75e-10 Intelligence (multi-trait analysis); CRC cis rs10870270 1.000 rs10159746 chr10:133742677 C/T cg17892150 chr10:133769511 PPP2R2D -0.71 -10.85 -0.51 1.24e-23 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; CRC cis rs597539 0.654 rs619727 chr11:68627535 A/G cg06112835 chr11:68658793 MRPL21 0.47 7.7 0.39 1.61e-13 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC trans rs7618501 0.633 rs4688758 chr3:50028385 G/A cg21659725 chr3:3221576 CRBN 0.6 9.38 0.46 1.09e-18 Intelligence (multi-trait analysis); CRC cis rs7465272 0.500 rs7463655 chr8:143731034 G/C cg24634471 chr8:143751801 JRK 0.52 7.15 0.37 5.69e-12 Bipolar disorder and schizophrenia; CRC trans rs2243480 0.803 rs55700941 chr7:65389800 T/A cg10756647 chr7:56101905 PSPH 0.69 7.36 0.38 1.47e-12 Diabetic kidney disease; CRC cis rs7586879 0.616 rs6545813 chr2:25131287 C/T cg22495460 chr2:25135724 ADCY3 -0.88 -17.69 -0.7 1.15e-49 Body mass index; CRC cis rs7833790 0.777 rs10958042 chr8:82678393 G/T cg27398817 chr8:82754497 SNX16 -0.49 -6.02 -0.32 4.59e-9 Diastolic blood pressure; CRC cis rs4731207 0.561 rs6975148 chr7:124686508 A/G cg23710748 chr7:124431027 NA -0.39 -6.22 -0.32 1.54e-9 Cutaneous malignant melanoma; CRC cis rs763014 0.966 rs4984904 chr16:680809 C/G cg00802000 chr16:706648 WDR90 -0.41 -5.92 -0.31 8.25e-9 Height; CRC cis rs7119 0.717 rs34981488 chr15:77723403 T/G cg17802220 chr15:77601643 NA -0.45 -6.51 -0.34 2.79e-10 Type 2 diabetes; CRC cis rs67311347 1.000 rs12494022 chr3:40426652 A/C cg09455208 chr3:40491958 NA 0.49 9.32 0.46 1.73e-18 Renal cell carcinoma; CRC cis rs1552244 0.882 rs17050660 chr3:10001772 A/G cg16606324 chr3:10149918 C3orf24 -0.62 -8.25 -0.41 3.78e-15 Alzheimer's disease; CRC cis rs9443645 0.808 rs9361484 chr6:79758218 C/A cg05283184 chr6:79620031 NA -0.61 -9.7 -0.47 1.01e-19 Intelligence (multi-trait analysis); CRC cis rs9584850 0.834 rs9584854 chr13:99118590 C/T cg07423050 chr13:99094983 FARP1 0.43 6.0 0.31 5.22e-9 Neuroticism; CRC cis rs736801 0.808 rs2522057 chr5:131801947 C/G cg14196790 chr5:131705035 SLC22A5 0.36 5.88 0.31 1.02e-8 Breast cancer;Mosquito bite size; CRC cis rs2470135 1 rs2470135 chr15:43995789 C/T cg02155558 chr15:43621948 ADAL;LCMT2 0.49 6.94 0.36 2.04e-11 Diastolic blood pressure; CRC cis rs763121 0.853 rs5757208 chr22:39049230 A/C cg06544989 chr22:39130855 UNC84B 0.45 6.86 0.35 3.39e-11 Menopause (age at onset); CRC cis rs1580019 0.563 rs2392071 chr7:32572536 G/A cg14728415 chr7:32535168 LSM5;AVL9 0.43 5.98 0.31 5.7e-9 Cognitive ability; CRC trans rs4942242 1.000 rs9594987 chr13:44230994 C/T cg26741380 chr15:41871084 TYRO3 0.41 6.11 0.32 2.82e-9 Response to tocilizumab in rheumatoid arthritis; CRC cis rs11190604 1.000 rs11190572 chr10:102232879 A/G cg07080220 chr10:102295463 HIF1AN 0.47 5.69 0.3 2.82e-8 Palmitoleic acid (16:1n-7) levels; CRC cis rs10540 0.818 rs12806089 chr11:501468 G/A cg08200582 chr11:442649 ANO9 -0.71 -7.44 -0.38 8.72e-13 Body mass index; CRC cis rs10876993 0.855 rs1678520 chr12:58049319 C/G cg18357645 chr12:58087776 OS9 0.57 7.75 0.39 1.17e-13 Celiac disease or Rheumatoid arthritis; CRC cis rs12530845 0.887 rs59400686 chr7:135360029 A/G cg23117316 chr7:135346802 PL-5283 -0.43 -6.0 -0.31 5.32e-9 Red blood cell traits; CRC cis rs7546094 1.000 rs6691932 chr1:113144263 T/C cg22162597 chr1:113214053 CAPZA1 0.43 6.02 0.31 4.69e-9 Platelet distribution width; CRC cis rs7177699 0.557 rs7165902 chr15:79115872 T/G cg15571903 chr15:79123663 NA 0.31 6.13 0.32 2.47e-9 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; CRC cis rs2243480 1.000 rs4718334 chr7:65789454 G/A cg12463550 chr7:65579703 CRCP -0.68 -6.19 -0.32 1.77e-9 Diabetic kidney disease; CRC trans rs2243480 0.711 rs2420172 chr7:65635341 T/C cg10756647 chr7:56101905 PSPH -0.76 -7.87 -0.4 5.31e-14 Diabetic kidney disease; CRC cis rs9311474 0.967 rs11717383 chr3:52287468 G/T cg08222913 chr3:52553049 STAB1 -0.36 -6.78 -0.35 5.62e-11 Electroencephalogram traits; CRC cis rs6563739 0.616 rs7985594 chr13:40218606 C/G cg00026919 chr13:40226031 NA 0.45 5.68 0.3 2.96e-8 Menarche (age at onset); CRC cis rs6754311 0.731 rs2164210 chr2:136580287 T/C cg25344623 chr2:136566232 LCT 0.32 5.81 0.31 1.47e-8 Mosquito bite size; CRC cis rs1570884 0.516 rs9316462 chr13:50176321 A/G cg03651054 chr13:50194643 NA 0.36 7.24 0.37 3.1e-12 Sum basophil neutrophil counts;Sum neutrophil eosinophil counts;Neutrophil count;Myeloid white cell count;Granulocyte count; CRC trans rs7267979 1.000 rs12428 chr20:25433821 G/T cg17903999 chr18:56338584 MALT1 0.42 7.23 0.37 3.51e-12 Liver enzyme levels (alkaline phosphatase); CRC cis rs1572438 0.899 rs9379160 chr6:859966 A/G cg21062780 chr6:887772 NA -0.34 -5.63 -0.3 3.88e-8 Aging; CRC cis rs9549367 0.789 rs3850451 chr13:113905812 C/G cg18105134 chr13:113819100 PROZ -0.74 -10.5 -0.5 1.94e-22 Platelet distribution width; CRC cis rs8014204 0.550 rs2302832 chr14:75137664 T/C cg03030879 chr14:75389066 RPS6KL1 -0.42 -6.53 -0.34 2.45e-10 Caffeine consumption; CRC cis rs713477 0.692 rs56280202 chr14:55911201 C/T cg13175173 chr14:55914753 NA -0.43 -7.52 -0.38 5.3e-13 Pediatric bone mineral content (femoral neck); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg13884470 chr9:86595151 HNRNPK;RMI1 0.48 8.42 0.42 1.19e-15 Liver disease severity in Alagille syndrome; CRC cis rs9491140 0.539 rs2208814 chr6:124692555 G/A cg19267163 chr6:125004984 NKAIN2 0.47 6.1 0.32 3.04e-9 Neuroticism; CRC cis rs7208859 0.524 rs77498725 chr17:29063986 C/T cg01831904 chr17:28903510 LRRC37B2 -0.62 -6.39 -0.33 5.8e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC trans rs1005277 0.579 rs1614236 chr10:38502996 C/T cg17830980 chr10:43048298 ZNF37B -0.6 -9.99 -0.48 1.07e-20 Extrinsic epigenetic age acceleration; CRC cis rs7107174 1.000 rs58235466 chr11:78030886 T/C cg02023728 chr11:77925099 USP35 0.46 7.8 0.4 8.25e-14 Testicular germ cell tumor; CRC cis rs6662572 0.686 rs11805376 chr1:46559664 C/G cg03123370 chr1:45965343 CCDC163P;MMACHC 0.49 6.38 0.33 6.09e-10 Blood protein levels; CRC cis rs4555082 0.834 rs2975217 chr14:105710238 A/C cg06808227 chr14:105710500 BRF1 -0.62 -8.98 -0.44 2.2e-17 Mean platelet volume;Platelet distribution width; CRC cis rs6570726 0.935 rs414222 chr6:145850482 C/T cg05347473 chr6:146136440 FBXO30 0.38 6.09 0.32 3.19e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs11190604 1.000 rs35106985 chr10:102307542 T/C cg16342193 chr10:102329863 NA -0.36 -5.99 -0.31 5.62e-9 Palmitoleic acid (16:1n-7) levels; CRC cis rs9549328 0.565 rs36145949 chr13:113616608 T/C cg24588162 chr13:113633484 MCF2L 0.36 6.43 0.33 4.47e-10 Systolic blood pressure; CRC cis rs941408 0.515 rs12610096 chr19:2778129 C/T cg17333051 chr19:2783644 SGTA 0.47 6.9 0.36 2.64e-11 Total cholesterol levels; CRC cis rs1552244 0.882 rs13099136 chr3:10031431 G/A cg10729496 chr3:10149963 C3orf24 0.49 6.35 0.33 7.07e-10 Alzheimer's disease; CRC cis rs2120019 1.000 rs12901243 chr15:75374233 C/T cg09165964 chr15:75287851 SCAMP5 -0.8 -12.62 -0.57 4.92e-30 Blood trace element (Zn levels); CRC cis rs9611565 0.513 rs739135 chr22:42090069 A/C cg06634786 chr22:41940651 POLR3H 0.63 7.15 0.37 5.78e-12 Vitiligo; CRC cis rs4713118 0.662 rs469228 chr6:27970704 A/G cg15786705 chr6:28176104 NA 0.64 9.23 0.45 3.27e-18 Parkinson's disease; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg23983136 chr10:88768846 AGAP11 -0.35 -5.98 -0.31 5.82e-9 Liver disease severity in Alagille syndrome; CRC trans rs2975734 1.000 rs2975734 chr8:10090097 C/G cg06636001 chr8:8085503 FLJ10661 -0.42 -6.07 -0.32 3.54e-9 Morning vs. evening chronotype;Chronotype; CRC cis rs6141769 0.542 rs28548407 chr20:31301495 T/C cg13636640 chr20:31349939 DNMT3B -0.39 -5.84 -0.31 1.27e-8 Subjective well-being; CRC trans rs9858542 1.000 rs2172252 chr3:49678307 A/T cg21582582 chr3:182698605 DCUN1D1 -0.54 -6.54 -0.34 2.38e-10 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs67311347 1.000 rs11539046 chr3:40503809 G/A cg24209194 chr3:40518798 ZNF619 -0.42 -6.07 -0.32 3.62e-9 Renal cell carcinoma; CRC cis rs11723261 0.582 rs4634177 chr4:136837 C/T cg12746427 chr4:53362 ZNF718;ZNF595 0.46 6.25 0.33 1.28e-9 Immune response to smallpox vaccine (IL-6); CRC cis rs6547741 1.000 rs1972669 chr2:27767107 T/G cg27432699 chr2:27873401 GPN1 0.76 13.43 0.59 4.46e-33 Oral cavity cancer; CRC cis rs11098499 1.000 rs1011054 chr4:120202387 A/G cg09307838 chr4:120376055 NA -0.62 -9.07 -0.45 1.09e-17 Corneal astigmatism; CRC cis rs2019137 0.539 rs11123170 chr2:113978940 C/G cg02675527 chr2:114030824 PAX8;LOC440839 -0.42 -6.17 -0.32 1.99e-9 Lymphocyte counts; CRC cis rs9916302 0.706 rs6503500 chr17:37485925 C/T cg15445000 chr17:37608096 MED1 0.34 6.11 0.32 2.81e-9 Glomerular filtration rate (creatinine); CRC cis rs4481887 0.516 rs11204613 chr1:248379155 A/G cg00666640 chr1:248458726 OR2T12 -0.35 -6.33 -0.33 7.89e-10 Common traits (Other); CRC cis rs7660520 0.557 rs76004373 chr4:183731011 C/G cg01126855 chr4:183727586 NA 0.58 5.78 0.3 1.76e-8 Pediatric autoimmune diseases; CRC cis rs9611565 0.694 rs106860 chr22:41840407 C/T cg06634786 chr22:41940651 POLR3H -0.69 -7.82 -0.4 7.19e-14 Vitiligo; CRC cis rs17666538 0.792 rs1669715 chr8:593641 T/C cg26554054 chr8:600488 NA 0.69 6.94 0.36 2.15e-11 IgG glycosylation; CRC cis rs3806843 0.966 rs2240693 chr5:140183325 G/C cg16607685 chr5:140181889 PCDHA2;PCDHA1;PCDHA3 -0.27 -6.19 -0.32 1.83e-9 Depressive symptoms (multi-trait analysis); CRC cis rs2032447 0.802 rs12346 chr6:26097046 T/C cg18357526 chr6:26021779 HIST1H4A 0.77 11.62 0.54 2.23e-26 Intelligence (multi-trait analysis); CRC trans rs7267979 0.966 rs2261720 chr20:25260641 T/G cg17903999 chr18:56338584 MALT1 -0.41 -6.76 -0.35 6.14e-11 Liver enzyme levels (alkaline phosphatase); CRC cis rs2213920 0.619 rs7042718 chr9:118202187 C/T cg13918206 chr9:118159781 DEC1 0.6 5.88 0.31 9.92e-9 Docetaxel-induced peripheral neuropathy in metastatic castrate-resistant prostate cancer; CRC cis rs1005277 0.579 rs932538 chr10:38381314 T/C cg00409905 chr10:38381863 ZNF37A -0.66 -11.29 -0.53 3.38e-25 Extrinsic epigenetic age acceleration; CRC cis rs2223471 0.967 rs2281158 chr6:50730735 C/G cg03432817 chr6:50765336 NA 0.39 6.32 0.33 8.72e-10 Subcutaneous adipose tissue; CRC cis rs4481887 1.000 rs6683717 chr1:248476792 A/G cg13385794 chr1:248469461 NA 0.4 6.74 0.35 6.91e-11 Common traits (Other); CRC cis rs4888262 0.508 rs7193583 chr16:74649589 C/G cg01733217 chr16:74700730 RFWD3 0.8 12.31 0.56 6.7200000000000006e-29 Testicular germ cell tumor; CRC cis rs1797081 1.000 rs1797081 chr10:16874565 A/G cg23933602 chr10:16859644 RSU1 1.05 20.58 0.75 4.42e-61 Platelet distribution width; CRC cis rs11098499 0.754 rs28652763 chr4:120242312 C/T cg24375607 chr4:120327624 NA 0.48 7.61 0.39 2.87e-13 Corneal astigmatism; CRC cis rs7666738 0.791 rs1967978 chr4:98966152 T/C cg17366294 chr4:99064904 C4orf37 0.43 7.36 0.38 1.49e-12 Colonoscopy-negative controls vs population controls; CRC cis rs6952808 0.582 rs11763870 chr7:2027448 T/C cg04267008 chr7:1944627 MAD1L1 0.55 7.9 0.4 4.1e-14 Bipolar disorder and schizophrenia; CRC cis rs6743376 0.509 rs1530552 chr2:113818120 G/T cg09040174 chr2:113837401 NA 0.44 6.4 0.33 5.36e-10 Inflammatory biomarkers; CRC cis rs9467773 0.901 rs1407045 chr6:26476155 A/G cg09904177 chr6:26538194 HMGN4 0.7 10.82 0.51 1.46e-23 Intelligence (multi-trait analysis); CRC cis rs7412746 0.658 rs3768015 chr1:150812954 C/T cg10589385 chr1:150898437 SETDB1 0.32 6.53 0.34 2.43e-10 Melanoma; CRC cis rs13082711 0.911 rs11718991 chr3:27452944 A/G cg02860705 chr3:27208620 NA 0.6 8.47 0.42 8.42e-16 Systolic blood pressure;Diastolic blood pressure;Blood pressure; CRC cis rs7904368 0.806 rs4612698 chr10:16855070 C/A cg14835575 chr10:16859367 RSU1 0.49 6.7 0.35 9.14e-11 Ratio of the peak velocity of the mitral E-Wave divided by the peak velocity of the mitral A-wave.; CRC cis rs13082711 0.554 rs66854845 chr3:27387008 C/T cg02860705 chr3:27208620 NA 0.86 10.95 0.52 5.42e-24 Systolic blood pressure;Diastolic blood pressure;Blood pressure; CRC cis rs4731207 0.509 rs6977699 chr7:124617109 A/G cg23710748 chr7:124431027 NA -0.39 -6.26 -0.33 1.22e-9 Cutaneous malignant melanoma; CRC cis rs6964587 0.782 rs13221571 chr7:91500236 C/T cg17063962 chr7:91808500 NA -0.76 -12.89 -0.58 4.87e-31 Breast cancer; CRC trans rs12367572 0.620 rs1857925 chr12:45344385 T/C cg23954465 chr10:8078038 NA -0.28 -6.19 -0.32 1.8e-9 Gut microbiome composition (summer); CRC cis rs501120 0.866 rs607609 chr10:44750209 T/C cg09554077 chr10:44749378 NA 0.89 13.17 0.59 4.18e-32 Coronary artery disease;Coronary heart disease; CRC cis rs1784581 0.588 rs7453474 chr6:162421736 C/T cg17173639 chr6:162384350 PARK2 0.6 9.71 0.47 9.23e-20 Itch intensity from mosquito bite; CRC cis rs514406 0.621 rs881198 chr1:53196440 C/T cg24675658 chr1:53192096 ZYG11B 0.67 10.43 0.5 3.45e-22 Monocyte count; CRC cis rs8078723 0.690 rs3785549 chr17:38149724 T/C cg17344932 chr17:38183730 MED24;SNORD124 0.48 7.98 0.4 2.38e-14 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); CRC cis rs7680126 0.597 rs78917351 chr4:10208063 A/C cg11266682 chr4:10021025 SLC2A9 -0.41 -6.01 -0.31 4.92e-9 Urate levels in lean individuals;Urate levels in overweight individuals;Urate levels in obese individuals; CRC cis rs8060686 0.565 rs8044328 chr16:68146859 G/C cg26727032 chr16:67993705 SLC12A4 -0.6 -8.11 -0.41 1.04e-14 HDL cholesterol;Metabolic syndrome; CRC cis rs853679 0.546 rs200953 chr6:27837267 T/C cg06470822 chr6:28175283 NA 0.65 5.61 0.3 4.22e-8 Depression; CRC cis rs11190604 1.000 rs12219789 chr10:102213778 A/G cg07570687 chr10:102243282 WNT8B 0.44 5.66 0.3 3.36e-8 Palmitoleic acid (16:1n-7) levels; CRC cis rs7209700 0.547 rs884696 chr17:45341244 C/A cg08085267 chr17:45401833 C17orf57 0.58 7.28 0.37 2.44e-12 IgG glycosylation; CRC cis rs6032067 0.929 rs56168207 chr20:43803971 C/T cg10761708 chr20:43804764 PI3 0.51 5.82 0.31 1.37e-8 Blood protein levels; CRC cis rs9341808 0.718 rs2143887 chr6:80917287 T/C cg08355045 chr6:80787529 NA 0.43 6.94 0.36 2.08e-11 Sitting height ratio; CRC cis rs7259376 0.905 rs2082479 chr19:22539847 T/C cg02657401 chr19:22469223 NA -0.34 -7.62 -0.39 2.73e-13 Menopause (age at onset); CRC cis rs11098499 0.738 rs72918577 chr4:120326701 G/A cg24375607 chr4:120327624 NA 0.51 7.69 0.39 1.69e-13 Corneal astigmatism; CRC cis rs7737355 0.947 rs13174006 chr5:130963473 A/G cg06307176 chr5:131281290 NA 0.45 6.44 0.33 4.33e-10 Life satisfaction; CRC cis rs9611519 0.780 rs9611528 chr22:41648502 T/C cg03806693 chr22:41940476 POLR3H -0.64 -9.02 -0.45 1.6e-17 Neuroticism; CRC cis rs9905704 0.846 rs302861 chr17:56697040 G/C cg12560992 chr17:57184187 TRIM37 0.57 8.3 0.42 2.69e-15 Testicular germ cell tumor; CRC cis rs3809863 0.602 rs6504833 chr17:45396087 A/G cg25173405 chr17:45401733 C17orf57 -0.65 -10.52 -0.5 1.71e-22 Glaucoma (primary open-angle); CRC cis rs2046867 0.862 rs62251645 chr3:72805733 T/C cg25664220 chr3:72788482 NA -0.46 -6.39 -0.33 5.6e-10 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; CRC cis rs68170813 0.559 rs10953534 chr7:106913718 A/G cg02696742 chr7:106810147 HBP1 0.54 5.91 0.31 8.53e-9 Coronary artery disease; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg24119481 chr19:16683605 SLC35E1 0.47 6.1 0.32 3.02e-9 Thyroid stimulating hormone; CRC cis rs10540 0.570 rs8176330 chr11:535798 G/A cg08200582 chr11:442649 ANO9 -0.69 -7.04 -0.36 1.16e-11 Body mass index; CRC cis rs7659604 0.539 rs2221628 chr4:122795361 G/A cg06713675 chr4:122721982 EXOSC9 -0.51 -8.29 -0.42 2.97e-15 Type 2 diabetes; CRC cis rs7172809 0.897 rs16968893 chr15:77825082 A/G cg10437265 chr15:77819839 NA -0.4 -6.84 -0.35 3.8e-11 Glucose homeostasis traits; CRC cis rs7274811 0.711 rs291697 chr20:31985248 T/C cg07470512 chr20:32255052 NECAB3;C20orf134 0.43 5.8 0.3 1.55e-8 Height; CRC cis rs7635838 0.964 rs7624086 chr3:11412620 C/G cg00170343 chr3:11313890 ATG7 0.42 6.31 0.33 9.06e-10 HDL cholesterol; CRC cis rs1707322 0.721 rs10890337 chr1:46124527 C/T cg06784218 chr1:46089804 CCDC17 0.66 12.35 0.56 4.77e-29 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs3540 0.512 rs8033818 chr15:91075535 C/T cg22089800 chr15:90895588 ZNF774 -0.57 -9.47 -0.46 5.75e-19 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; CRC cis rs1865760 0.566 rs2794720 chr6:26087202 G/C cg18357526 chr6:26021779 HIST1H4A 0.43 6.09 0.32 3.08e-9 Height; CRC cis rs1008375 0.931 rs10008337 chr4:17593849 G/C cg02297831 chr4:17616191 MED28 0.43 5.61 0.3 4.33e-8 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs10256972 0.758 rs9801444 chr7:1080444 A/C cg03188948 chr7:1209495 NA -0.43 -6.29 -0.33 1.02e-9 Longevity;Endometriosis; CRC trans rs45509595 0.822 rs200484 chr6:27775674 A/G cg16898833 chr6:26189333 HIST1H4D 0.72 6.44 0.33 4.31e-10 Breast cancer; CRC cis rs4653767 0.573 rs708772 chr1:226912891 A/G cg05049329 chr1:226924846 ITPKB 0.32 7.11 0.37 7.16e-12 Parkinson's disease; CRC cis rs7945705 0.747 rs10840158 chr11:9020897 A/C cg00186954 chr11:8933980 ST5;C11orf17 -0.45 -7.57 -0.38 3.88e-13 Hemoglobin concentration; CRC cis rs514406 0.505 rs269287 chr1:53168842 T/C cg24675658 chr1:53192096 ZYG11B -0.69 -10.79 -0.51 1.89e-23 Monocyte count; CRC cis rs2227564 0.729 rs2675676 chr10:75648287 A/C cg00564723 chr10:75632066 CAMK2G -0.33 -7.52 -0.38 5.23e-13 Crohn's disease;Inflammatory bowel disease; CRC cis rs172166 0.543 rs1150691 chr6:28168033 A/G cg06470822 chr6:28175283 NA 0.71 10.51 0.5 1.76e-22 Cardiac Troponin-T levels; CRC cis rs11212617 1.000 rs641605 chr11:108101919 C/T cg01991180 chr11:108092276 ATM;NPAT 0.42 6.15 0.32 2.25e-9 Response to metformin in type 2 diabetes (glycemic); CRC cis rs2836974 0.563 rs997147 chr21:40695325 A/G cg22974920 chr21:40686053 BRWD1 -0.42 -5.77 -0.3 1.8e-8 Cognitive function; CRC cis rs6714710 0.603 rs895438 chr2:98382886 G/A cg26665480 chr2:98280029 ACTR1B 0.54 7.23 0.37 3.37e-12 Posterior cortical atrophy and Alzheimer's disease; CRC cis rs2032447 0.966 rs7756117 chr6:26046565 A/G cg26028573 chr6:26043587 HIST1H2BB -0.45 -6.92 -0.36 2.32e-11 Intelligence (multi-trait analysis); CRC cis rs780096 0.546 rs1260320 chr2:27722416 A/G cg22903471 chr2:27725779 GCKR 0.37 6.04 0.32 4.2e-9 Total body bone mineral density; CRC cis rs17767392 0.881 rs2190240 chr14:72024889 T/C cg13720639 chr14:72061746 SIPA1L1 0.56 6.93 0.36 2.25e-11 Mitral valve prolapse; CRC trans rs1814175 0.817 rs10839465 chr11:49981554 C/A cg11707556 chr5:10655725 ANKRD33B -0.44 -8.34 -0.42 2.03e-15 Height; CRC cis rs9914988 0.943 rs12453504 chr17:27119524 C/A cg16670446 chr17:27188758 MIR451;MIR144 0.55 8.52 0.43 5.75e-16 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC trans rs1451375 0.617 rs2876829 chr7:50566762 A/G cg05839533 chr17:39642907 KRT36 -0.33 -5.96 -0.31 6.54e-9 Malaria; CRC trans rs1455244 0.700 rs7229302 chr18:11508904 G/T cg03525424 chr17:48238931 NA 0.4 5.97 0.31 6.15e-9 Schizophrenia; CRC cis rs9937943 0.721 rs8059315 chr16:74506447 C/G cg01733217 chr16:74700730 RFWD3 0.7 8.17 0.41 6.89e-15 Neutrophil percentage of white cells; CRC trans rs2243480 0.901 rs1701759 chr7:65470932 G/T cg10756647 chr7:56101905 PSPH 0.73 7.98 0.4 2.44e-14 Diabetic kidney disease; CRC cis rs477692 1.000 rs558764 chr10:131426957 G/T cg05714579 chr10:131428358 MGMT -0.55 -8.26 -0.41 3.67e-15 Response to temozolomide; CRC cis rs826838 0.967 rs826879 chr12:39088999 A/C cg26384229 chr12:38710491 ALG10B -0.62 -9.47 -0.46 5.71e-19 Heart rate; CRC cis rs7829975 0.617 rs4841071 chr8:8791144 G/T cg06636001 chr8:8085503 FLJ10661 0.45 6.94 0.36 2.07e-11 Mood instability; CRC cis rs908922 0.887 rs1415432 chr1:152480654 G/A cg23254163 chr1:152506842 NA 0.41 6.83 0.35 4.06e-11 Hair morphology; CRC cis rs10504229 1.000 rs67236942 chr8:58176525 T/C cg01721255 chr8:58191610 C8orf71 0.49 6.17 0.32 2e-9 Developmental language disorder (linguistic errors); CRC cis rs6988985 0.560 rs4736343 chr8:143933200 G/A cg10324643 chr8:143916377 GML 0.39 6.32 0.33 8.73e-10 Plasma androstenedione levels in resected early stage-receptor positive breast cancer; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg12571687 chr6:44215362 HSP90AB1 0.44 6.54 0.34 2.35e-10 Liver disease severity in Alagille syndrome; CRC cis rs9911578 0.967 rs7502208 chr17:57165097 G/A cg12560992 chr17:57184187 TRIM37 0.95 18.05 0.71 4.22e-51 Intelligence (multi-trait analysis); CRC cis rs7647973 1.000 rs6805609 chr3:49471522 C/G cg07690219 chr3:49449608 TCTA;RHOA 0.5 5.76 0.3 1.95e-8 Menarche (age at onset); CRC cis rs9549367 0.724 rs7985335 chr13:113869244 G/T cg00898013 chr13:113819073 PROZ 0.4 5.88 0.31 1.01e-8 Platelet distribution width; CRC cis rs7833790 0.724 rs10958045 chr8:82722994 T/C cg17211192 chr8:82754475 SNX16 -0.48 -6.84 -0.35 3.75e-11 Diastolic blood pressure; CRC cis rs8180040 0.800 rs7632501 chr3:47268306 T/C cg27129171 chr3:47204927 SETD2 -0.68 -10.39 -0.5 4.54e-22 Colorectal cancer; CRC cis rs9443645 0.869 rs1567168 chr6:79536455 G/T cg05283184 chr6:79620031 NA -0.58 -9.43 -0.46 7.82e-19 Intelligence (multi-trait analysis); CRC cis rs875971 0.545 rs316328 chr7:65608838 A/G cg18876405 chr7:65276391 NA -0.42 -6.13 -0.32 2.5e-9 Aortic root size; CRC cis rs11212617 1.000 rs609429 chr11:108196509 G/C cg01991180 chr11:108092276 ATM;NPAT 0.42 6.27 0.33 1.14e-9 Response to metformin in type 2 diabetes (glycemic); CRC cis rs13191362 1.000 rs35103567 chr6:163183400 G/A cg06582575 chr6:163149167 PACRG;PARK2 0.89 11.51 0.54 5.41e-26 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs4731207 0.698 rs2107936 chr7:124449041 A/T cg23710748 chr7:124431027 NA 0.37 5.96 0.31 6.53e-9 Cutaneous malignant melanoma; CRC cis rs6964587 1.000 rs4644173 chr7:91759597 A/G cg17063962 chr7:91808500 NA 0.85 15.0 0.64 4.01e-39 Breast cancer; CRC cis rs1799949 1.000 rs12936816 chr17:41301709 C/T cg01879757 chr17:41196368 BRCA1 -0.44 -6.67 -0.35 1.06e-10 Menopause (age at onset); CRC cis rs478304 0.651 rs948493 chr11:65552154 C/T cg27068330 chr11:65405492 SIPA1 -0.63 -9.33 -0.46 1.66e-18 Acne (severe); CRC cis rs6860806 0.507 rs169256 chr5:131688533 A/G cg09877947 chr5:131593287 PDLIM4 0.42 5.93 0.31 7.83e-9 Breast cancer; CRC cis rs6684514 1.000 rs2273833 chr1:156233189 C/T cg16558208 chr1:156270281 VHLL 0.61 9.63 0.47 1.73e-19 Mean corpuscular hemoglobin concentration;Glycated hemoglobin levels; CRC cis rs11031096 0.676 rs7120125 chr11:3941264 C/T cg18678763 chr11:4115507 RRM1 0.35 5.77 0.3 1.88e-8 Mean corpuscular volume;Mean corpuscular hemoglobin; CRC cis rs4711336 0.967 rs4711338 chr6:33660188 T/C cg14003231 chr6:33640908 ITPR3 0.46 7.36 0.38 1.5e-12 Height; CRC cis rs1218582 0.740 rs1977879 chr1:154879743 G/A cg09359103 chr1:154839909 KCNN3 -0.71 -12.5 -0.57 1.33e-29 Prostate cancer; CRC trans rs7395662 1.000 rs2221559 chr11:48707973 A/G cg21153622 chr11:89784906 NA 0.46 7.41 0.38 1.05e-12 HDL cholesterol; CRC cis rs77633900 0.772 rs157769 chr15:76834397 G/A cg21673338 chr15:77095150 SCAPER -0.73 -6.28 -0.33 1.04e-9 Non-glioblastoma glioma;Glioma; CRC cis rs11645898 0.935 rs3812985 chr16:72187957 A/T cg14768367 chr16:72042858 DHODH -0.48 -5.84 -0.31 1.23e-8 Blood protein levels; CRC cis rs875971 1.000 rs6961155 chr7:65933295 T/C cg12463550 chr7:65579703 CRCP 0.48 6.78 0.35 5.54e-11 Aortic root size; CRC cis rs7584330 0.554 rs76605518 chr2:238425992 G/A cg14458575 chr2:238380390 NA 0.46 6.57 0.34 2.02e-10 Prostate cancer; CRC cis rs2242194 0.816 rs2242193 chr1:154995503 A/G cg06221963 chr1:154839813 KCNN3 0.39 6.08 0.32 3.26e-9 Schizophrenia; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg15323084 chr1:1556707 MIB2 -0.44 -6.06 -0.32 3.73e-9 Anxiety disorder; CRC cis rs1728785 1.000 rs1645979 chr16:68603660 G/T cg02972257 chr16:68554789 NA -0.64 -7.57 -0.39 3.83e-13 Ulcerative colitis; CRC trans rs8123881 0.733 rs7268466 chr20:15810676 C/T cg16326998 chr7:5553266 FBXL18 0.56 6.48 0.34 3.4e-10 Body mass index; CRC cis rs1348850 0.526 rs9288003 chr2:178446572 T/G cg27490568 chr2:178487706 NA 0.53 6.69 0.35 9.55e-11 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg02280908 chr2:28615925 FOSL2 0.46 6.82 0.35 4.37e-11 Intelligence (multi-trait analysis); CRC cis rs4713118 0.513 rs149959 chr6:28013854 T/C cg25164649 chr6:28176230 NA 0.58 8.29 0.42 2.9e-15 Parkinson's disease; CRC cis rs6570726 0.935 rs384806 chr6:145814889 C/G cg05347473 chr6:146136440 FBXO30 0.37 5.93 0.31 7.63e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs6964587 0.869 rs10241720 chr7:91527367 G/T cg17063962 chr7:91808500 NA -0.74 -12.39 -0.56 3.53e-29 Breast cancer; CRC cis rs1577917 0.883 rs9450375 chr6:86756629 C/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A 0.48 6.46 0.34 3.76e-10 Response to antipsychotic treatment; CRC cis rs896854 0.625 rs4735336 chr8:95973410 A/C cg09323728 chr8:95962352 TP53INP1 0.43 7.13 0.37 6.3e-12 Type 2 diabetes; CRC cis rs6540559 1.000 rs2235373 chr1:209963803 G/A cg25204440 chr1:209979598 IRF6 0.52 6.77 0.35 5.93e-11 Cleft lip with or without cleft palate; CRC cis rs11098499 0.866 rs12374352 chr4:120281977 C/T cg09307838 chr4:120376055 NA 0.68 10.53 0.5 1.51e-22 Corneal astigmatism; CRC cis rs1788820 0.957 rs1652375 chr18:21109269 T/C cg14672496 chr18:21087552 C18orf8 0.55 9.74 0.47 7.5e-20 Body mass index; CRC cis rs12142240 0.698 rs67200518 chr1:46835777 T/C cg14993813 chr1:46806288 NSUN4 -0.48 -6.1 -0.32 2.93e-9 Menopause (age at onset); CRC cis rs9611565 0.765 rs727563 chr22:41867377 C/T cg03806693 chr22:41940476 POLR3H 0.75 10.57 0.5 1.16e-22 Vitiligo; CRC cis rs7086627 0.515 rs11202957 chr10:82209592 A/G cg09626299 chr10:82213104 TSPAN14 -0.37 -6.23 -0.33 1.39e-9 Post bronchodilator FEV1; CRC cis rs2832191 0.791 rs2832181 chr21:30481371 G/T cg08807101 chr21:30365312 RNF160 -0.64 -10.32 -0.49 8.16e-22 Dental caries; CRC cis rs826838 0.967 rs1684411 chr12:39128494 C/T cg13010199 chr12:38710504 ALG10B -0.41 -5.86 -0.31 1.11e-8 Heart rate; CRC cis rs597539 0.690 rs11228383 chr11:68623228 T/G cg21963583 chr11:68658836 MRPL21 0.6 10.28 0.49 1.15e-21 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs11212617 0.934 rs2056267 chr11:108061808 C/A cg01991180 chr11:108092276 ATM;NPAT 0.4 5.85 0.31 1.18e-8 Response to metformin in type 2 diabetes (glycemic); CRC cis rs4713118 0.824 rs2092075 chr6:27749330 G/C cg02683197 chr6:28174875 NA 0.66 8.59 0.43 3.46e-16 Parkinson's disease; CRC cis rs6952808 0.691 rs2398709 chr7:2112548 C/T cg02951883 chr7:2050386 MAD1L1 -0.69 -10.55 -0.5 1.29e-22 Bipolar disorder and schizophrenia; CRC cis rs2290405 0.527 rs6829987 chr4:932974 C/G cg09237302 chr4:906077 GAK 0.44 7.52 0.38 5.16e-13 Systemic sclerosis; CRC cis rs9660180 0.935 rs2180311 chr1:1748734 T/C cg17747265 chr1:1875780 NA -0.74 -12.73 -0.57 1.85e-30 Body mass index; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg27658640 chr17:4843839 RNF167;SLC25A11 0.48 6.93 0.36 2.19e-11 Response to antipsychotic treatment; CRC cis rs2929278 0.562 rs8033846 chr15:44035363 A/C cg02155558 chr15:43621948 ADAL;LCMT2 -0.43 -5.83 -0.31 1.31e-8 Schizophrenia; CRC cis rs1799949 1.000 rs12516 chr17:41196408 G/A cg19454999 chr17:41278357 BRCA1;NBR2 0.54 8.52 0.43 5.78e-16 Menopause (age at onset); CRC cis rs4474465 1.000 rs12280198 chr11:78161361 C/T cg27205649 chr11:78285834 NARS2 -0.45 -5.87 -0.31 1.08e-8 Alzheimer's disease (survival time); CRC cis rs1707322 1.000 rs12124291 chr1:46432132 G/A cg06784218 chr1:46089804 CCDC17 0.51 9.05 0.45 1.28e-17 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs9522267 0.535 rs2039915 chr13:112238794 C/T cg10483660 chr13:112241077 NA -0.5 -9.77 -0.47 5.93e-20 Hepatitis; CRC cis rs847649 1.000 rs847648 chr7:102553850 C/T cg18108683 chr7:102477205 FBXL13 -0.57 -9.36 -0.46 1.31e-18 Morning vs. evening chronotype; CRC cis rs10504229 1.000 rs66672857 chr8:58179817 G/C cg05313129 chr8:58192883 C8orf71 -0.47 -6.99 -0.36 1.49e-11 Developmental language disorder (linguistic errors); CRC cis rs17401966 0.931 rs746881 chr1:10346810 C/T cg19773385 chr1:10388646 KIF1B 0.69 11.07 0.52 2.08e-24 Hepatocellular carcinoma; CRC cis rs7824557 0.583 rs2736292 chr8:11234500 A/T cg20542592 chr8:11973495 FAM66D -0.32 -5.72 -0.3 2.39e-8 Retinal vascular caliber; CRC cis rs2878628 0.596 rs57039206 chr3:52758570 T/A cg08222913 chr3:52553049 STAB1 -0.34 -6.17 -0.32 2e-9 Intelligence (multi-trait analysis); CRC trans rs57221529 1.000 rs57221529 chr5:586624 A/G cg25482853 chr8:67687455 SGK3 1.15 13.73 0.6 3.24e-34 Lung disease severity in cystic fibrosis; CRC cis rs7666738 0.822 rs28512427 chr4:98919029 G/A cg05340658 chr4:99064831 C4orf37 0.57 8.65 0.43 2.24e-16 Colonoscopy-negative controls vs population controls; CRC cis rs9733 0.596 rs2065900 chr1:150652202 A/G cg15448220 chr1:150897856 SETDB1 0.45 6.43 0.33 4.42e-10 Tonsillectomy; CRC cis rs1577917 0.958 rs12202712 chr6:86578541 T/A cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.51 -6.8 -0.35 5.07e-11 Response to antipsychotic treatment; CRC cis rs9291683 0.527 rs73212848 chr4:10093299 T/C cg11266682 chr4:10021025 SLC2A9 -0.48 -9.33 -0.46 1.6e-18 Bone mineral density; CRC cis rs9322817 0.583 rs9377667 chr6:105154880 G/A cg02098413 chr6:105308735 HACE1 -0.42 -8.22 -0.41 4.63e-15 Thyroid stimulating hormone; CRC cis rs57221529 0.766 rs56350081 chr5:583198 G/A cg16447950 chr5:562315 NA -0.83 -10.78 -0.51 2.14e-23 Lung disease severity in cystic fibrosis; CRC cis rs769267 0.965 rs4808937 chr19:19398005 A/G cg01262667 chr19:19385393 TM6SF2 0.37 6.17 0.32 2.05e-9 Tonsillectomy; CRC cis rs8180040 0.966 rs11705957 chr3:47443262 T/G cg02527881 chr3:46936655 PTH1R 0.37 6.74 0.35 6.98e-11 Colorectal cancer; CRC cis rs9926296 0.744 rs164746 chr16:89709019 C/T cg01097406 chr16:89675127 NA 0.52 9.39 0.46 1.01e-18 Vitiligo; CRC cis rs68170813 0.562 rs7810216 chr7:107000353 G/A cg02696742 chr7:106810147 HBP1 -0.54 -5.87 -0.31 1.04e-8 Coronary artery disease; CRC cis rs6456156 0.774 rs1556413 chr6:167524743 G/A cg07513332 chr6:167530253 CCR6 -0.4 -7.02 -0.36 1.27e-11 Primary biliary cholangitis; CRC cis rs12142240 0.698 rs72677593 chr1:46824363 T/C cg14993813 chr1:46806288 NSUN4 -0.49 -6.22 -0.32 1.55e-9 Menopause (age at onset); CRC cis rs4363385 0.791 rs489323 chr1:153006047 G/A cg25856811 chr1:152973957 SPRR3 -0.25 -6.99 -0.36 1.51e-11 Inflammatory skin disease; CRC cis rs798554 0.721 rs2527680 chr7:2892361 C/T cg19717773 chr7:2847554 GNA12 -0.5 -6.98 -0.36 1.64e-11 Height; CRC cis rs883565 0.655 rs7633233 chr3:39146724 G/T cg01426195 chr3:39028469 NA -0.54 -8.53 -0.43 5.32e-16 Handedness; CRC cis rs1552244 1.000 rs111392584 chr3:10075991 A/G cg10729496 chr3:10149963 C3orf24 0.55 7.11 0.37 7.07e-12 Alzheimer's disease; CRC trans rs6951245 0.572 rs60918895 chr7:1039036 C/T cg13565492 chr6:43139072 SRF -0.76 -5.97 -0.31 5.98e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs1707322 0.752 rs28568986 chr1:46207743 C/T cg06784218 chr1:46089804 CCDC17 0.65 12.05 0.55 5.8e-28 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs6700896 0.931 rs10749755 chr1:66129530 C/T cg04111102 chr1:66153794 NA 0.35 6.1 0.32 3.03e-9 C-reactive protein;Mean corpuscular volume;Mean corpuscular hemoglobin; CRC cis rs10504229 0.728 rs55812114 chr8:58157453 C/T cg11062466 chr8:58055876 NA 0.45 6.01 0.31 4.87e-9 Developmental language disorder (linguistic errors); CRC cis rs10210302 0.502 rs880116 chr2:234246264 C/T cg07618928 chr2:234183455 ATG16L1;SCARNA5 0.42 6.23 0.32 1.43e-9 Crohn's disease; CRC cis rs10504229 1.000 rs6987435 chr8:58177334 G/A cg01721255 chr8:58191610 C8orf71 0.49 6.15 0.32 2.28e-9 Developmental language disorder (linguistic errors); CRC cis rs6835098 0.887 rs12644699 chr4:174142874 A/G cg08422745 chr4:174089978 GALNT7 0.91 13.96 0.61 4.08e-35 Dementia and core Alzheimer's disease neuropathologic changes; CRC cis rs7814319 0.700 rs35290014 chr8:97263930 T/C cg20787634 chr8:97240163 UQCRB -0.46 -7.45 -0.38 8.34e-13 Lung function (FVC); CRC cis rs9309711 0.506 rs9284794 chr2:3492052 G/A cg08493051 chr2:3487164 NA -0.42 -6.12 -0.32 2.62e-9 Neurofibrillary tangles; CRC cis rs4481887 0.597 rs2185358 chr1:248585259 T/A cg00666640 chr1:248458726 OR2T12 0.36 6.16 0.32 2.13e-9 Common traits (Other); CRC cis rs9443645 0.901 rs1960542 chr6:79566643 C/T cg09184832 chr6:79620586 NA -0.51 -9.72 -0.47 8.25e-20 Intelligence (multi-trait analysis); CRC cis rs7618501 0.699 rs1317154 chr3:49910084 T/C cg24308560 chr3:49941425 MST1R -0.5 -7.9 -0.4 4.12e-14 Intelligence (multi-trait analysis); CRC cis rs7605827 0.930 rs6759785 chr2:15529269 A/C cg19274914 chr2:15703543 NA 0.39 5.77 0.3 1.82e-8 Educational attainment (years of education); CRC cis rs10504229 1.000 rs116995796 chr8:58181960 G/A cg01721255 chr8:58191610 C8orf71 0.5 6.19 0.32 1.81e-9 Developmental language disorder (linguistic errors); CRC cis rs6502050 0.835 rs9904520 chr17:80100117 T/C cg13198984 chr17:80129470 CCDC57 0.46 8.16 0.41 6.94e-15 Life satisfaction; CRC cis rs12760731 0.720 rs12161419 chr1:178379040 A/C cg00404053 chr1:178313656 RASAL2 0.98 10.15 0.49 3.04e-21 Obesity-related traits; CRC cis rs4731207 0.596 rs1531717 chr7:124644690 G/T cg23710748 chr7:124431027 NA -0.39 -6.25 -0.33 1.24e-9 Cutaneous malignant melanoma; CRC cis rs4253772 0.550 rs9615951 chr22:46728056 C/A cg24881330 chr22:46731750 TRMU 0.61 6.48 0.34 3.28e-10 LDL cholesterol;Cholesterol, total; CRC cis rs875971 0.545 rs316328 chr7:65608838 A/G cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.59 -8.04 -0.41 1.64e-14 Aortic root size; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg13030908 chr1:11741533 MAD2L2 0.44 6.23 0.32 1.47e-9 Response to antipsychotic treatment; CRC trans rs800082 1.000 rs11718059 chr3:144305997 G/A cg24215973 chr2:240111563 HDAC4 -0.51 -6.89 -0.36 2.89e-11 Smoking behavior; CRC cis rs16975963 0.644 rs12162238 chr19:38082385 A/T cg15135657 chr19:38346511 NA -0.46 -6.32 -0.33 8.7e-10 Longevity; CRC trans rs4263408 0.934 rs9683743 chr4:39703194 A/C cg11251499 chr4:57774202 REST -0.42 -6.4 -0.33 5.49e-10 Plasma amyloid beta peptide concentrations (ABx-40); CRC cis rs1005224 0.654 rs8005753 chr14:76136086 A/T cg04684003 chr14:76127793 TTLL5;C14orf1 -0.51 -7.38 -0.38 1.3e-12 Large artery stroke; CRC cis rs28386778 0.897 rs4968662 chr17:61834537 A/G cg22520471 chr17:61851767 DDX42;CCDC47 0.74 11.6 0.54 2.6e-26 Prudent dietary pattern; CRC trans rs7647973 0.626 rs9835157 chr3:49797769 G/A cg21665057 chr3:196295764 WDR53;FBXO45 0.61 6.73 0.35 7.76e-11 Menarche (age at onset); CRC cis rs58235267 0.591 rs4671457 chr2:63346356 C/T cg24726965 chr2:63606136 C2orf86 -0.38 -5.8 -0.3 1.58e-8 Prostate-specific antigen levels (conditioned on lead SNPs); CRC cis rs428668 0.523 rs6898671 chr5:150677643 A/T cg14086364 chr5:150678334 SLC36A3 0.4 6.96 0.36 1.8e-11 Skin aging (microtopography measurement); CRC cis rs970548 0.738 rs61854124 chr10:46077158 T/C cg15590007 chr10:45870220 ALOX5 0.58 5.99 0.31 5.6e-9 Total cholesterol levels;Cholesterol, total;HDL cholesterol;HDL cholesterol levels; CRC cis rs7584330 0.744 rs58223447 chr2:238378644 G/C cg11271282 chr2:238384023 NA 0.48 5.63 0.3 3.83e-8 Prostate cancer; CRC cis rs57994353 0.600 rs10870163 chr9:139315594 G/A cg14119001 chr9:139324193 INPP5E -0.44 -5.89 -0.31 9.75e-9 Eosinophil counts;Cutaneous squamous cell carcinoma; CRC cis rs10971721 0.822 rs10971802 chr9:33933282 A/G cg13495928 chr9:33750294 PRSS3 0.56 5.95 0.31 6.96e-9 Body mass index; CRC cis rs3733585 0.699 rs7663079 chr4:9966771 T/C cg00071950 chr4:10020882 SLC2A9 -0.55 -9.63 -0.47 1.67e-19 Cleft plate (environmental tobacco smoke interaction); CRC cis rs1018836 0.599 rs9643295 chr8:91492283 T/G cg16814680 chr8:91681699 NA -0.57 -8.52 -0.43 5.82e-16 Ejection fraction in Tripanosoma cruzi seropositivity; CRC cis rs1552244 0.554 rs2272120 chr3:10046703 C/T cg08888203 chr3:10149979 C3orf24 0.48 7.32 0.37 1.9e-12 Alzheimer's disease; CRC cis rs28386778 0.897 rs4968597 chr17:61805747 G/A cg22520471 chr17:61851767 DDX42;CCDC47 0.72 11.14 0.52 1.11e-24 Prudent dietary pattern; CRC cis rs11971779 0.553 rs10085770 chr7:139100349 G/A cg07862535 chr7:139043722 LUC7L2 0.57 7.32 0.37 1.92e-12 Diisocyanate-induced asthma; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg09426994 chr11:118478258 PHLDB1 -0.4 -6.11 -0.32 2.81e-9 Myopia (pathological); CRC cis rs2075371 0.932 rs1862048 chr7:133978167 C/G cg20476274 chr7:133979776 SLC35B4 -0.7 -12.41 -0.56 2.76e-29 Mean platelet volume; CRC trans rs637571 0.510 rs12575663 chr11:65574535 G/A cg17712092 chr4:129076599 LARP1B -0.54 -8.27 -0.41 3.34e-15 Eosinophil percentage of white cells; CRC cis rs7937682 0.575 rs34695265 chr11:111719128 T/C cg09085632 chr11:111637200 PPP2R1B 0.94 15.71 0.65 6.81e-42 Primary sclerosing cholangitis; CRC cis rs9372498 0.536 rs1319987 chr6:118782236 A/G cg01339444 chr6:118972232 C6orf204 0.54 6.02 0.32 4.65e-9 Diastolic blood pressure; CRC cis rs6089584 0.888 rs6061981 chr20:60618973 T/C cg18761221 chr20:60518478 NA 0.45 7.21 0.37 3.8e-12 Body mass index; CRC cis rs7772486 0.686 rs9390347 chr6:146044747 G/T cg23711669 chr6:146136114 FBXO30 -0.65 -10.71 -0.51 3.69e-23 Lobe attachment (rater-scored or self-reported); CRC cis rs2760061 0.655 rs686533 chr1:228119604 A/G cg02753203 chr1:228287806 NA -0.69 -10.77 -0.51 2.22e-23 Diastolic blood pressure; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg14655249 chr9:86595816 HNRNPK;RMI1 0.48 6.25 0.33 1.29e-9 Thyroid stimulating hormone; CRC cis rs6142102 0.961 rs1055857 chr20:32613873 A/G cg08999081 chr20:33150536 PIGU 0.37 5.64 0.3 3.71e-8 Skin pigmentation; CRC cis rs2635047 0.601 rs2635052 chr18:44650607 C/G cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.37 5.71 0.3 2.57e-8 Educational attainment; CRC cis rs8177253 0.665 rs9831392 chr3:133451473 A/T cg01448562 chr3:133502909 NA -0.39 -6.23 -0.32 1.41e-9 Iron status biomarkers; CRC cis rs6500395 1.000 rs3848319 chr16:48610933 T/C cg04672837 chr16:48644449 N4BP1 0.45 6.75 0.35 6.7e-11 Response to tocilizumab in rheumatoid arthritis; CRC cis rs9359856 0.623 rs1179906 chr6:90323624 T/C cg13799429 chr6:90582589 CASP8AP2 -0.65 -9.43 -0.46 7.64e-19 Bipolar disorder; CRC cis rs3126085 0.935 rs12409762 chr1:152175398 G/A cg09127314 chr1:152161683 NA -0.46 -5.68 -0.3 2.95e-8 Atopic dermatitis; CRC cis rs2549003 1.000 rs2070723 chr5:131823187 A/G cg00255919 chr5:131827918 IRF1 0.58 11.45 0.53 8.9e-26 Asthma (sex interaction); CRC cis rs4481887 1.000 rs4244176 chr1:248468231 G/A cg00666640 chr1:248458726 OR2T12 0.52 9.16 0.45 5.86e-18 Common traits (Other); CRC cis rs7937682 0.889 rs1789355 chr11:111499718 T/C cg19812747 chr11:111475976 SIK2 -0.57 -9.74 -0.47 7.45e-20 Primary sclerosing cholangitis; CRC cis rs10256972 0.706 rs12701970 chr7:1121958 T/C cg23708337 chr7:1209742 NA 0.4 5.82 0.31 1.4e-8 Longevity;Endometriosis; CRC cis rs425277 0.538 rs169037 chr1:2095582 G/T cg03732007 chr1:2071316 PRKCZ 0.36 5.72 0.3 2.38e-8 Height; CRC cis rs1218582 0.688 rs2135219 chr1:154857217 G/A cg06221963 chr1:154839813 KCNN3 -0.82 -14.68 -0.63 6.92e-38 Prostate cancer; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg04910470 chr15:41709534 RTF1 0.39 6.4 0.33 5.27e-10 Liver disease severity in Alagille syndrome; CRC cis rs9311676 0.656 rs11917567 chr3:58382254 C/T cg06643156 chr3:58380774 PXK 0.41 6.34 0.33 7.65e-10 Systemic lupus erythematosus; CRC cis rs853679 0.517 rs4713135 chr6:28039586 G/A cg02631126 chr6:28058918 ZSCAN12L1 0.29 6.1 0.32 2.93e-9 Depression; CRC cis rs9811920 0.638 rs10936008 chr3:99686665 C/T cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G 0.45 5.96 0.31 6.36e-9 Axial length; CRC cis rs1129187 0.755 rs3293 chr6:42938377 G/T cg05552183 chr6:42928497 GNMT 0.52 8.0 0.4 2.14e-14 Alzheimer's disease in APOE e4+ carriers; CRC cis rs847577 0.609 rs6465658 chr7:97816638 C/G cg00277769 chr7:97922759 BAIAP2L1 -0.4 -6.51 -0.34 2.81e-10 Breast cancer; CRC cis rs2019137 0.560 rs4849179 chr2:113985170 C/T cg21482265 chr2:113992762 PAX8;LOC440839;LOC654433 0.6 9.23 0.45 3.31e-18 Lymphocyte counts; CRC cis rs863345 0.604 rs11264991 chr1:158472861 T/G cg12129480 chr1:158549410 OR10X1 -0.3 -6.24 -0.33 1.33e-9 Pneumococcal bacteremia; CRC cis rs7584330 0.554 rs13431733 chr2:238430275 A/G cg14458575 chr2:238380390 NA 0.54 7.09 0.36 8.5e-12 Prostate cancer; CRC cis rs4555082 0.874 rs2245329 chr14:105719181 T/C cg13114125 chr14:105738426 BRF1 -0.79 -11.8 -0.55 4.92e-27 Mean platelet volume;Platelet distribution width; CRC cis rs7538876 0.935 rs4920607 chr1:17760098 A/G cg01904812 chr1:17746340 RCC2 0.39 6.33 0.33 8.12e-10 Basal cell carcinoma; CRC cis rs2153535 0.580 rs7769020 chr6:8457724 G/A cg21535247 chr6:8435926 SLC35B3 0.51 7.9 0.4 4.36e-14 Motion sickness; CRC cis rs4481887 0.927 rs10158431 chr1:248481253 A/G cg00666640 chr1:248458726 OR2T12 0.55 9.53 0.47 3.53e-19 Common traits (Other); CRC cis rs2070677 1.000 rs1329149 chr10:135349801 T/C cg16964102 chr10:135390573 NA -0.49 -6.88 -0.35 3.09e-11 Gout; CRC cis rs9527 0.590 rs10509766 chr10:104926334 T/C cg15744005 chr10:104629667 AS3MT -0.31 -6.18 -0.32 1.91e-9 Arsenic metabolism; CRC cis rs6586163 1.000 rs1926195 chr10:90753758 G/A cg13456138 chr10:90753195 FAS -0.43 -6.61 -0.34 1.56e-10 Chronic lymphocytic leukemia; CRC cis rs4664293 0.625 rs11693108 chr2:160428587 C/T cg08347373 chr2:160653686 CD302 -0.38 -6.41 -0.33 4.95e-10 Monocyte percentage of white cells; CRC cis rs11122272 0.735 rs2790893 chr1:231508976 T/G cg06096015 chr1:231504339 EGLN1 0.4 5.95 0.31 6.7e-9 Hemoglobin concentration; CRC cis rs425277 0.606 rs2257182 chr1:2082566 C/T cg03732007 chr1:2071316 PRKCZ -0.41 -6.92 -0.36 2.34e-11 Height; CRC cis rs2120019 1.000 rs8033837 chr15:75353975 A/C cg09165964 chr15:75287851 SCAMP5 -0.83 -12.74 -0.57 1.67e-30 Blood trace element (Zn levels); CRC cis rs904251 1.000 rs10947673 chr6:37445079 C/T cg01843034 chr6:37503916 NA -0.38 -6.94 -0.36 2.05e-11 Cognitive performance; CRC cis rs11690935 0.595 rs788170 chr2:172919958 T/C cg13550731 chr2:172543902 DYNC1I2 0.65 9.71 0.47 8.97e-20 Schizophrenia; CRC cis rs728616 0.614 rs61859210 chr10:82131468 G/C cg11900509 chr10:81946545 ANXA11 -0.56 -6.3 -0.33 9.41e-10 Chronic obstructive pulmonary disease-related biomarkers; CRC trans rs10506458 1.000 rs1009539 chr12:63414655 A/G cg22491629 chr6:157744540 C6orf35 0.69 7.93 0.4 3.55e-14 Hemostatic factors and hematological phenotypes; CRC cis rs11123170 0.529 rs112692022 chr2:113970182 C/T cg12889195 chr2:113992843 PAX8;LOC440839;LOC654433 0.49 5.84 0.31 1.26e-8 Renal function-related traits (BUN); CRC cis rs13191362 0.938 rs35395472 chr6:163008493 G/A cg06582575 chr6:163149167 PACRG;PARK2 0.75 10.24 0.49 1.58e-21 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs7666738 0.830 rs17027058 chr4:98864671 G/A cg05340658 chr4:99064831 C4orf37 0.59 8.89 0.44 3.97e-17 Colonoscopy-negative controls vs population controls; CRC cis rs473651 0.935 rs474478 chr2:239335473 C/T cg21699342 chr2:239360505 ASB1 0.57 10.26 0.49 1.33e-21 Multiple system atrophy; CRC cis rs1005277 0.579 rs2474608 chr10:38457109 C/T cg17219203 chr10:38645113 HSD17B7P2 -0.4 -5.65 -0.3 3.39e-8 Extrinsic epigenetic age acceleration; CRC cis rs4713118 0.586 rs6905516 chr6:28086478 A/G cg06470822 chr6:28175283 NA 1.0 13.06 0.58 1.06e-31 Parkinson's disease; CRC cis rs7412746 0.658 rs12097963 chr1:150870450 T/C cg17724175 chr1:150552817 MCL1 0.44 6.55 0.34 2.27e-10 Melanoma; CRC cis rs9467711 0.606 rs72841536 chr6:26378288 T/A cg16898833 chr6:26189333 HIST1H4D 0.84 7.08 0.36 8.95e-12 Autism spectrum disorder or schizophrenia; CRC cis rs79349575 0.749 rs2546491 chr17:46977916 A/G cg00947319 chr17:47005597 UBE2Z -0.34 -5.93 -0.31 7.7e-9 Type 2 diabetes; CRC cis rs73200209 0.744 rs59619030 chr12:116475001 T/C cg01776926 chr12:116560359 MED13L -0.63 -7.5 -0.38 6.13e-13 Total body bone mineral density; CRC cis rs989128 0.614 rs1132414 chr17:48628092 A/G cg24438145 chr17:48624694 SPATA20 0.51 7.37 0.38 1.35e-12 Type 2 diabetes; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg03771185 chr4:775700 NA 0.46 6.46 0.34 3.83e-10 Response to antipsychotic treatment; CRC cis rs7246967 0.608 rs2569725 chr19:23016010 C/A cg23217946 chr19:22817039 ZNF492 0.4 5.62 0.3 3.98e-8 Bronchopulmonary dysplasia; CRC cis rs10946940 0.965 rs6910838 chr6:27515519 A/C cg08798685 chr6:27730294 NA 0.38 5.69 0.3 2.76e-8 Systemic lupus erythematosus; CRC cis rs72627123 0.867 rs112464051 chr14:74483975 C/T cg12022184 chr14:74485813 ENTPD5;C14orf45 0.71 5.81 0.3 1.5e-8 Morning vs. evening chronotype; CRC cis rs1007738 0.580 rs2279439 chr11:47196982 C/T cg19486271 chr11:47235900 DDB2 0.45 5.89 0.31 9.63e-9 Bone mineral density (hip); CRC cis rs875971 0.545 rs6970498 chr7:65740895 A/G cg05627663 chr7:65219948 SNORA22;CCT6P1 0.61 7.99 0.4 2.29e-14 Aortic root size; CRC cis rs977987 0.806 rs17696696 chr16:75393352 G/T cg03315344 chr16:75512273 CHST6 -0.53 -8.76 -0.44 1.02e-16 Dupuytren's disease; CRC cis rs853679 0.517 rs9357066 chr6:28129831 T/C cg03623178 chr6:28175578 NA 0.98 12.66 0.57 3.31e-30 Depression; CRC cis rs17270561 0.609 rs9356985 chr6:25728098 C/T cg17691542 chr6:26056736 HIST1H1C 0.73 9.31 0.46 1.82e-18 Iron status biomarkers; CRC cis rs4481887 0.604 rs10888330 chr1:248410506 A/T cg00666640 chr1:248458726 OR2T12 0.41 6.55 0.34 2.26e-10 Common traits (Other); CRC cis rs17376456 0.825 rs55724660 chr5:93276636 A/G cg25358565 chr5:93447407 FAM172A 1.11 10.62 0.51 7.72e-23 Diabetic retinopathy; CRC cis rs7666738 0.791 rs1115615 chr4:99006614 G/A cg17366294 chr4:99064904 C4orf37 0.43 7.32 0.37 1.94e-12 Colonoscopy-negative controls vs population controls; CRC cis rs6714710 0.603 rs11691494 chr2:98419726 T/A cg26665480 chr2:98280029 ACTR1B 0.52 7.18 0.37 4.53e-12 Posterior cortical atrophy and Alzheimer's disease; CRC cis rs12024301 0.557 rs10911391 chr1:183617094 G/A cg11505048 chr1:183622726 RGL1;APOBEC4 0.81 7.0 0.36 1.42e-11 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs7618915 0.547 rs13085331 chr3:52627486 G/C cg18099408 chr3:52552593 STAB1 -0.44 -7.27 -0.37 2.7e-12 Bipolar disorder; CRC cis rs1448094 0.692 rs7958438 chr12:86326141 A/T cg19622623 chr12:86230825 RASSF9 -0.36 -5.63 -0.3 3.79e-8 Major depressive disorder; CRC cis rs60843830 1.000 rs17713729 chr2:249092 A/C cg25945732 chr2:264204 ACP1;SH3YL1 0.71 11.98 0.55 1.12e-27 Spherical equivalent (joint analysis main effects and education interaction); CRC trans rs1455244 0.700 rs7229302 chr18:11508904 G/T cg02688348 chr11:57103429 SSRP1 0.41 6.1 0.32 2.96e-9 Schizophrenia; CRC cis rs9868809 0.772 rs34096717 chr3:48719453 A/C cg00383909 chr3:49044727 WDR6 0.73 7.29 0.37 2.25e-12 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; CRC cis rs2732480 1.000 rs2732480 chr12:48736303 A/C cg21466736 chr12:48725269 NA 0.47 7.45 0.38 8.09e-13 Hemoglobin concentration;Red blood cell count;Hematocrit; CRC cis rs853679 0.550 rs1150689 chr6:28165099 T/C cg12172441 chr6:28176163 NA 0.69 9.19 0.45 4.69e-18 Depression; CRC cis rs13161895 1.000 rs248318 chr5:179430530 C/T cg02702477 chr5:179499311 RNF130 0.56 6.47 0.34 3.5e-10 LDL cholesterol; CRC cis rs7635838 0.617 rs2594971 chr3:11313910 G/A cg00170343 chr3:11313890 ATG7 0.59 9.22 0.45 3.77e-18 HDL cholesterol; CRC cis rs12142240 0.698 rs17361812 chr1:46814008 C/T cg14993813 chr1:46806288 NSUN4 -0.5 -6.42 -0.33 4.75e-10 Menopause (age at onset); CRC cis rs7589728 1.000 rs12473740 chr2:88527647 A/G cg14558114 chr2:88469736 THNSL2 0.58 5.84 0.31 1.27e-8 Plasma clusterin levels; CRC cis rs354033 0.837 rs6971236 chr7:149184850 A/C cg24335155 chr7:149193227 ZNF746 -0.44 -6.83 -0.35 4.11e-11 Multiple sclerosis; CRC cis rs7811142 0.830 rs705866 chr7:99965285 T/C cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.94 11.88 0.55 2.51e-27 Platelet count; CRC cis rs35110281 0.837 rs2838343 chr21:45078035 C/T cg04455712 chr21:45112962 RRP1B 0.41 8.0 0.4 2.13e-14 Mean corpuscular volume; CRC trans rs4668356 0.543 rs1989613 chr2:172034292 A/G cg12499123 chr5:10250085 CCT5;FAM173B 0.66 6.0 0.31 5.3300000000000004e-09 Cognitive performance; CRC trans rs2055729 0.677 rs6990268 chr8:9741171 G/A cg08975724 chr8:8085496 FLJ10661 -0.47 -6.02 -0.31 4.54e-9 Multiple myeloma (hyperdiploidy); CRC cis rs8060686 0.641 rs7199588 chr16:68224582 C/T cg26727032 chr16:67993705 SLC12A4 -0.56 -7.5 -0.38 6e-13 HDL cholesterol;Metabolic syndrome; CRC cis rs13191362 0.872 rs73017702 chr6:163257695 C/A cg06582575 chr6:163149167 PACRG;PARK2 0.68 8.63 0.43 2.66e-16 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs10504229 0.728 rs72650867 chr8:58154912 C/T cg21724239 chr8:58056113 NA 0.62 8.38 0.42 1.51e-15 Developmental language disorder (linguistic errors); CRC cis rs75920871 0.588 rs7101763 chr11:116941985 G/T cg20608306 chr11:116969690 SIK3 -0.31 -5.64 -0.3 3.58e-8 Subjective well-being; CRC cis rs10479542 0.896 rs4701131 chr5:178982446 A/G cg19626725 chr5:178986131 RUFY1 0.36 7.36 0.38 1.51e-12 Lung cancer; CRC cis rs6951245 1.000 rs11763793 chr7:1094342 A/G cg03188948 chr7:1209495 NA 0.67 6.99 0.36 1.54e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs17209837 1.000 rs45554032 chr7:87078547 G/T cg00919237 chr7:87102261 ABCB4 -0.47 -5.61 -0.3 4.28e-8 Gallbladder cancer; CRC cis rs7615952 0.800 rs11915699 chr3:125632684 A/G cg05084668 chr3:125655381 ALG1L -0.54 -7.47 -0.38 7.4e-13 Blood pressure (smoking interaction); CRC cis rs9381040 0.655 rs2268194 chr6:41024447 T/C cg25110423 chr6:41068646 NFYA;LOC221442 -0.38 -5.77 -0.3 1.79e-8 Alzheimer's disease (late onset); CRC cis rs10089 0.953 rs10223203 chr5:127527646 A/T cg25462716 chr5:127418816 SLC12A2;FLJ33630 -0.69 -9.59 -0.47 2.37e-19 Ileal carcinoids; CRC cis rs9902453 0.904 rs8071742 chr17:28361669 A/C cg26525008 chr17:28256777 EFCAB5;SSH2 -0.59 -8.86 -0.44 4.95e-17 Coffee consumption (cups per day); CRC cis rs67478160 0.619 rs11628481 chr14:104241499 C/T cg01849466 chr14:104193079 ZFYVE21 -0.5 -8.89 -0.44 4.04e-17 Schizophrenia; CRC cis rs9648716 1.000 rs765373 chr7:140626976 C/T cg10747023 chr7:140774559 NA 0.46 6.02 0.31 4.76e-9 Type 2 diabetes; CRC trans rs1814175 0.817 rs4881658 chr11:49941123 G/A cg21153622 chr11:89784906 NA -0.39 -6.21 -0.32 1.6e-9 Height; CRC cis rs11098499 0.569 rs55845118 chr4:120290913 T/C cg24375607 chr4:120327624 NA 0.48 7.48 0.38 6.72e-13 Corneal astigmatism; CRC cis rs12143943 0.866 rs3789051 chr1:204494436 C/T cg17419461 chr1:204415978 PIK3C2B 0.39 6.02 0.32 4.6e-9 Cognitive performance; CRC cis rs9304742 0.962 rs12461796 chr19:53455088 T/A cg09915433 chr19:53449742 NA -0.6 -9.1 -0.45 8.63e-18 Psoriasis; CRC cis rs7586879 0.521 rs1865689 chr2:25108197 C/T cg04586622 chr2:25135609 ADCY3 0.54 10.11 0.49 4.14e-21 Body mass index; CRC cis rs9733 0.596 rs2175615 chr1:150624101 A/G cg10589385 chr1:150898437 SETDB1 0.28 5.98 0.31 5.86e-9 Tonsillectomy; CRC cis rs7707921 1.000 rs2407064 chr5:81457358 C/A cg17942617 chr5:81327376 ATG10 -0.38 -5.66 -0.3 3.34e-8 Breast cancer; CRC cis rs4713118 0.869 rs9295742 chr6:27702832 G/A cg08798685 chr6:27730294 NA -0.42 -6.26 -0.33 1.23e-9 Parkinson's disease; CRC cis rs10504229 0.683 rs11785260 chr8:58132906 A/G cg02725872 chr8:58115012 NA -0.64 -11.55 -0.54 3.85e-26 Developmental language disorder (linguistic errors); CRC cis rs244731 1.000 rs244731 chr5:176539679 C/T cg06060754 chr5:176797920 RGS14 0.58 7.61 0.39 2.86e-13 Urate levels in lean individuals; CRC cis rs7552404 0.889 rs1250874 chr1:76190978 A/G cg03433033 chr1:76189801 ACADM 0.75 11.61 0.54 2.42e-26 Blood metabolite levels;Acylcarnitine levels; CRC cis rs8060686 0.641 rs7188085 chr16:68113873 A/G cg26727032 chr16:67993705 SLC12A4 -0.61 -8.22 -0.41 4.66e-15 HDL cholesterol;Metabolic syndrome; CRC cis rs9467773 0.526 rs12199613 chr6:26367218 C/T cg14345882 chr6:26364793 BTN3A2 0.43 6.65 0.34 1.19e-10 Intelligence (multi-trait analysis); CRC cis rs1801251 1.000 rs1044480 chr2:233633736 A/G cg25237894 chr2:233734115 C2orf82 0.51 8.34 0.42 2.07e-15 Coronary artery disease; CRC cis rs9372498 0.536 rs62422229 chr6:118959288 T/C cg18833306 chr6:118973337 C6orf204 0.46 5.97 0.31 6.28e-9 Diastolic blood pressure; CRC cis rs2303745 0.589 rs1864115 chr19:17393327 G/C cg27101125 chr19:17392770 ANKLE1 -0.33 -5.75 -0.3 1.99e-8 Systemic lupus erythematosus; CRC cis rs710987 0.787 rs828544 chr5:3520064 G/T cg09148417 chr5:3513521 NA -0.28 -5.64 -0.3 3.72e-8 Response to cyclophosphamide in systemic lupus erythematosus with lupus nephritis; CRC cis rs13108904 0.517 rs4974551 chr4:1336410 C/A cg00684032 chr4:1343700 KIAA1530 0.59 8.26 0.41 3.54e-15 Obesity-related traits; CRC cis rs2243480 1.000 rs59794892 chr7:65415873 G/A cg18252515 chr7:66147081 NA -1.07 -12.45 -0.57 1.96e-29 Diabetic kidney disease; CRC cis rs12497850 1.000 rs6788650 chr3:48749543 T/C cg20833759 chr3:49053208 WDR6;DALRD3 0.44 7.43 0.38 9.15e-13 Parkinson's disease; CRC cis rs12477438 0.501 rs7349217 chr2:99815146 T/G cg26064155 chr2:99771622 LIPT1;TSGA10 0.81 14.16 0.62 7.15e-36 Chronic sinus infection; CRC cis rs3096299 0.658 rs4785679 chr16:89566113 G/T cg02187348 chr16:89574699 SPG7 0.4 5.92 0.31 8.23e-9 Multiple myeloma (IgH translocation); CRC cis rs677665 0.537 rs6688233 chr1:9335745 A/G cg25755851 chr1:9335794 NA -1.02 -17.18 -0.69 1.11e-47 Eosinophil percentage of white cells; CRC cis rs7626444 0.543 rs843528 chr3:196480335 G/A cg12930392 chr3:196481615 PAK2 0.4 7.26 0.37 2.73e-12 Monocyte count; CRC cis rs7091068 0.706 rs4919398 chr10:95429162 C/T cg20715218 chr10:95462985 C10orf4 0.53 5.83 0.31 1.35e-8 Urinary tract infection frequency; CRC cis rs4474465 0.920 rs10899532 chr11:78208470 T/G cg27205649 chr11:78285834 NARS2 0.48 6.08 0.32 3.34e-9 Alzheimer's disease (survival time); CRC cis rs8072100 0.805 rs67919208 chr17:45771873 T/C cg08085267 chr17:45401833 C17orf57 -0.51 -7.68 -0.39 1.82e-13 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs72781680 0.898 rs55846516 chr2:24158003 T/C cg08917208 chr2:24149416 ATAD2B 0.91 9.24 0.45 3.06e-18 Lymphocyte counts; CRC cis rs9611565 0.729 rs505533 chr22:41864216 A/C cg06634786 chr22:41940651 POLR3H 0.44 5.71 0.3 2.48e-8 Vitiligo; CRC cis rs4665809 1.000 rs2053367 chr2:26293413 T/C cg04944784 chr2:26401820 FAM59B -0.6 -7.62 -0.39 2.65e-13 Gut microbiome composition (summer); CRC cis rs2228479 0.850 rs12597296 chr16:89822331 C/T cg19635926 chr16:89946313 TCF25 0.63 5.68 0.3 3.01e-8 Skin colour saturation; CRC cis rs2274471 0.645 rs3780376 chr9:5109485 G/T cg03390472 chr9:5043263 JAK2 -0.54 -6.3 -0.33 9.67e-10 Crohn's disease; CRC cis rs4319547 0.695 rs1803290 chr12:122865029 T/C cg23029597 chr12:123009494 RSRC2 0.61 7.47 0.38 7.45e-13 Body mass index; CRC cis rs12995491 0.731 rs17435439 chr2:88511391 A/G cg14558114 chr2:88469736 THNSL2 -0.42 -6.18 -0.32 1.84e-9 Response to metformin (IC50); CRC cis rs4144743 1.000 rs34492688 chr17:45321622 C/A cg18085866 chr17:45331354 ITGB3 -0.59 -8.01 -0.4 1.96e-14 Body mass index; CRC cis rs17711722 0.740 rs7809991 chr7:65406218 A/G cg02869306 chr7:64672164 INTS4L1 -0.35 -5.95 -0.31 6.76e-9 Calcium levels; CRC cis rs13191362 0.872 rs13194619 chr6:163203657 C/T cg21926612 chr6:163149169 PACRG;PARK2 0.95 12.36 0.56 4.29e-29 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs514406 0.505 rs7543239 chr1:53162416 A/G cg24675658 chr1:53192096 ZYG11B -0.69 -10.7 -0.51 4.06e-23 Monocyte count; CRC cis rs597539 0.652 rs482172 chr11:68668437 C/A cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.89 15.41 0.65 1.03e-40 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs1008375 1.000 rs1008375 chr4:17682834 T/C cg16339924 chr4:17578868 LAP3 0.49 6.33 0.33 8.04e-10 Parasitemia in Tripanosoma cruzi seropositivity; CRC trans rs1945213 0.694 rs7129022 chr11:55876132 A/G cg15704280 chr7:45808275 SEPT13 0.55 6.11 0.32 2.87e-9 Acute lymphoblastic leukemia (childhood); CRC cis rs1552244 0.572 rs58862481 chr3:10164308 G/A cg02579736 chr3:10068473 FANCD2;CIDECP 1.04 11.89 0.55 2.36e-27 Alzheimer's disease; CRC cis rs7216064 1.000 rs6504555 chr17:65940727 A/G cg12091567 chr17:66097778 LOC651250 0.63 7.87 0.4 5.27e-14 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CRC trans rs2832077 0.943 rs2832084 chr21:30154798 A/G cg14791747 chr16:20752902 THUMPD1 0.54 6.72 0.35 8.13e-11 Cognitive test performance; CRC cis rs9747201 1.000 rs36048409 chr17:80096961 T/A cg14673194 chr17:80132900 CCDC57 0.49 6.37 0.33 6.36e-10 Peripheral arterial disease (traffic-related air pollution interaction); CRC trans rs1455244 0.700 rs7229302 chr18:11508904 G/T cg05863116 chr5:133562407 PPP2CA 0.39 6.19 0.32 1.75e-9 Schizophrenia; CRC cis rs4332037 0.624 rs11764124 chr7:1891723 C/G cg21155852 chr7:2048760 MAD1L1 -0.42 -6.16 -0.32 2.17e-9 Bipolar disorder; CRC cis rs863345 0.604 rs11265007 chr1:158498522 C/T cg12129480 chr1:158549410 OR10X1 0.3 6.31 0.33 8.92e-10 Pneumococcal bacteremia; CRC cis rs17592366 0.517 rs4982219 chr14:35286483 A/T cg09327582 chr14:35236912 BAZ1A 0.48 6.71 0.35 8.66e-11 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells; CRC cis rs4819052 0.851 rs2838848 chr21:46671017 A/G cg19498844 chr21:46707878 POFUT2;LOC642852 0.75 10.82 0.51 1.49e-23 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs701145 0.556 rs355764 chr3:154013480 A/T cg16511985 chr3:153974050 SGEF 0.46 6.07 0.32 3.55e-9 Coronary artery disease; CRC cis rs4555082 0.834 rs2816624 chr14:105733909 A/G cg06808227 chr14:105710500 BRF1 -0.62 -8.75 -0.43 1.16e-16 Mean platelet volume;Platelet distribution width; CRC cis rs4481887 1.000 rs4589143 chr1:248470446 A/G cg13385794 chr1:248469461 NA 0.37 6.44 0.33 4.21e-10 Common traits (Other); CRC cis rs17539620 0.628 rs62432729 chr6:154830044 T/C cg20019720 chr6:154832845 CNKSR3 0.49 7.92 0.4 3.61e-14 Lipoprotein (a) levels; CRC cis rs853679 0.517 rs9393898 chr6:28130376 G/T cg18032046 chr6:28092343 ZSCAN16 -0.52 -5.93 -0.31 7.58e-9 Depression; CRC cis rs2228479 1.000 rs62052186 chr16:89969567 A/T cg06558623 chr16:89946397 TCF25 1.08 10.71 0.51 3.77e-23 Skin colour saturation; CRC cis rs2806561 0.514 rs7414010 chr1:23543929 T/C cg19743168 chr1:23544995 NA 0.57 8.29 0.42 2.88e-15 Height; CRC cis rs11997175 1.000 rs7464996 chr8:33770925 G/T cg04338863 chr8:33670619 NA 0.36 5.69 0.3 2.74e-8 Body mass index; CRC cis rs17767392 0.958 rs10873246 chr14:72153693 A/G cg13720639 chr14:72061746 SIPA1L1 0.56 7.03 0.36 1.2e-11 Mitral valve prolapse; CRC cis rs172166 0.637 rs1225592 chr6:28150242 G/A cg21251018 chr6:28226885 NKAPL 0.47 7.36 0.38 1.44e-12 Cardiac Troponin-T levels; CRC trans rs7604735 0.963 rs957293 chr2:145833187 A/G cg26010734 chr19:15344046 EPHX3 -0.36 -6.01 -0.31 5.01e-9 Coronary artery disease; CRC trans rs10982213 0.830 rs2274163 chr9:117188714 C/T cg12044210 chr15:29213858 APBA2 0.37 6.09 0.32 3.1e-9 Interleukin-6 levels; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg21652505 chr19:40023540 EID2B 0.39 6.09 0.32 3.2e-9 Liver disease severity in Alagille syndrome; CRC trans rs2241685 0.680 rs11695699 chr2:1954444 G/A cg24940230 chr11:8046101 NA 0.49 6.0 0.31 5.3300000000000004e-09 Attention deficit hyperactivity disorder; CRC cis rs73195822 0.667 rs7967408 chr12:111164408 A/C cg12870014 chr12:110450643 ANKRD13A 0.75 8.89 0.44 4.07e-17 Itch intensity from mosquito bite; CRC cis rs2985684 0.948 rs12886130 chr14:50082753 T/C cg10008539 chr14:50087325 RPL36AL;MGAT2 -0.46 -6.07 -0.32 3.59e-9 Carotid intima media thickness; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg17330983 chr14:23770641 PPP1R3E 0.44 6.03 0.32 4.47e-9 Response to antipsychotic treatment; CRC cis rs6604026 0.922 rs12728322 chr1:93294792 C/T cg17283838 chr1:93427260 FAM69A 0.44 5.6 0.3 4.47e-8 Multiple sclerosis; CRC cis rs7542091 0.739 rs10863793 chr1:210037420 G/A cg22029157 chr1:209979665 IRF6 0.44 6.61 0.34 1.51e-10 Monobrow; CRC cis rs11626933 1.000 rs61989986 chr14:90739180 G/A cg14092571 chr14:90743983 NA -0.93 -14.93 -0.64 7.46e-39 Gut microbiota (bacterial taxa); CRC cis rs4148883 0.603 rs1893883 chr4:100124716 C/G cg13256891 chr4:100009986 ADH5 0.4 5.9 0.31 8.95e-9 Alcohol dependence; CRC cis rs2455601 0.786 rs10279 chr11:8969309 T/C cg21881798 chr11:8931708 C11orf17;ST5 -0.5 -5.86 -0.31 1.11e-8 Schizophrenia; CRC cis rs35306767 0.951 rs11253530 chr10:993729 T/C cg26597838 chr10:835615 NA 1.04 12.52 0.57 1.13e-29 Eosinophil percentage of granulocytes; CRC cis rs2067615 0.542 rs4433659 chr12:107082496 G/T cg13491945 chr12:107078410 RFX4 0.36 6.18 0.32 1.89e-9 Heart rate; CRC cis rs10504229 0.593 rs2317990 chr8:58024168 G/T cg21724239 chr8:58056113 NA 0.58 7.75 0.39 1.17e-13 Developmental language disorder (linguistic errors); CRC cis rs12995491 0.763 rs1914735 chr2:88511953 A/T cg24977027 chr2:88469347 THNSL2 -0.33 -5.64 -0.3 3.71e-8 Response to metformin (IC50); CRC cis rs644799 0.710 rs12273579 chr11:95524421 G/A cg25478527 chr11:95522999 CEP57;FAM76B 0.49 7.62 0.39 2.66e-13 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs10791323 0.569 rs2282601 chr11:133712594 C/G cg03690763 chr11:133734501 NA -0.35 -5.86 -0.31 1.14e-8 Childhood ear infection; CRC cis rs117623576 0.680 rs211415 chr10:32397358 C/T cg03047570 chr10:32398778 NA 0.66 7.04 0.36 1.1e-11 Anti-saccade response; CRC trans rs7395662 0.786 rs12791074 chr11:49005023 G/A cg21153622 chr11:89784906 NA -0.5 -7.95 -0.4 2.95e-14 HDL cholesterol; CRC cis rs780096 0.546 rs1647284 chr2:27608115 C/T cg24768116 chr2:27665128 KRTCAP3 -0.35 -7.84 -0.4 6.39e-14 Total body bone mineral density; CRC cis rs16975963 0.790 rs11083434 chr19:38283953 A/G cg15135657 chr19:38346511 NA -0.44 -5.89 -0.31 9.55e-9 Longevity; CRC cis rs7605827 0.930 rs13030859 chr2:15701038 G/A cg19274914 chr2:15703543 NA 0.37 5.63 0.3 3.95e-8 Educational attainment (years of education); CRC trans rs7824557 0.564 rs12550129 chr8:11233917 C/T cg06636001 chr8:8085503 FLJ10661 -0.49 -7.4 -0.38 1.16e-12 Retinal vascular caliber; CRC trans rs7267979 1.000 rs2424712 chr20:25416942 T/C cg17903999 chr18:56338584 MALT1 -0.42 -6.98 -0.36 1.6e-11 Liver enzyme levels (alkaline phosphatase); CRC cis rs2845885 0.793 rs3751120 chr11:63884453 C/T cg05555928 chr11:63887634 MACROD1 -0.52 -6.32 -0.33 8.31e-10 Body mass index; CRC cis rs847577 0.677 rs10242903 chr7:97741795 C/T cg24562669 chr7:97807699 LMTK2 -0.61 -11.48 -0.53 6.83e-26 Breast cancer; CRC cis rs185694 1.000 rs846495 chr13:30894250 T/C cg07600127 chr13:30881527 KATNAL1 -0.56 -5.87 -0.31 1.09e-8 Antineutrophil cytoplasmic antibody-associated vasculitis; CRC cis rs2573652 0.963 rs2573649 chr15:100514040 C/G cg00587665 chr15:100533223 ADAMTS17 -0.36 -6.08 -0.32 3.37e-9 Height; CRC cis rs56235845 0.694 rs36102285 chr5:176774018 C/T cg06060754 chr5:176797920 RGS14 0.53 8.43 0.42 1.13e-15 Hemoglobin concentration;Hematocrit; CRC cis rs1552244 1.000 rs7648104 chr3:10073311 C/A cg16606324 chr3:10149918 C3orf24 0.73 9.77 0.47 5.73e-20 Alzheimer's disease; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg04314247 chr1:95286125 SLC44A3 0.47 8.29 0.42 2.84e-15 Liver disease severity in Alagille syndrome; CRC cis rs28386778 0.897 rs2665833 chr17:61906846 T/C cg22520471 chr17:61851767 DDX42;CCDC47 0.75 11.86 0.55 3e-27 Prudent dietary pattern; CRC cis rs28386778 0.901 rs2665855 chr17:61965143 A/G cg25654072 chr17:61904446 PSMC5;FTSJ3 0.7 10.37 0.5 5.38e-22 Prudent dietary pattern; CRC cis rs8180040 0.726 rs34344887 chr3:47042161 A/G cg02527881 chr3:46936655 PTH1R -0.38 -6.93 -0.36 2.25e-11 Colorectal cancer; CRC cis rs4713118 0.955 rs9468206 chr6:27690453 G/T cg15845792 chr6:28175446 NA 0.61 8.01 0.4 2.04e-14 Parkinson's disease; CRC cis rs2050392 0.517 rs160018 chr10:30772703 T/C cg18806716 chr10:30721971 MAP3K8 -0.54 -7.37 -0.38 1.35e-12 Inflammatory bowel disease; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg27051335 chr15:75018733 CYP1A1 0.45 6.14 0.32 2.39e-9 Anxiety disorder; CRC cis rs637571 0.512 rs660118 chr11:65735174 G/C cg17985854 chr11:65770987 BANF1;EIF1AD 0.55 8.83 0.44 6.27e-17 Eosinophil percentage of white cells; CRC cis rs1669338 0.588 rs3864050 chr3:3186769 T/C cg16797762 chr3:3221439 CRBN -0.61 -5.68 -0.3 2.93e-8 White matter integrity; CRC cis rs6674176 0.660 rs3791112 chr1:44379248 T/G cg15962314 chr1:44399869 ARTN 0.31 5.92 0.31 8.08e-9 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Cognitive ability; CRC cis rs6585424 1.000 rs12268619 chr10:81920660 A/C cg11900509 chr10:81946545 ANXA11 -0.72 -8.84 -0.44 5.82e-17 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs2404602 0.716 rs67888330 chr15:76752483 A/G cg23625390 chr15:77176239 SCAPER 0.49 7.24 0.37 3.1e-12 Blood metabolite levels; CRC cis rs3892630 0.824 rs2287884 chr19:33321447 A/G cg22980127 chr19:33182716 NUDT19 0.91 11.3 0.53 3.14e-25 Red blood cell traits; CRC cis rs10876993 0.890 rs7963927 chr12:58046272 T/G cg18357645 chr12:58087776 OS9 0.58 7.99 0.4 2.23e-14 Celiac disease or Rheumatoid arthritis; CRC cis rs6963495 0.519 rs3892297 chr7:105152173 G/A cg02135003 chr7:105160482 PUS7 -0.9 -11.7 -0.54 1.09e-26 Bipolar disorder (body mass index interaction); CRC cis rs6951245 1.000 rs76804143 chr7:1082021 C/T cg22907277 chr7:1156413 C7orf50 0.72 7.47 0.38 7.14e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs4665809 1.000 rs4665823 chr2:26312723 A/G cg04944784 chr2:26401820 FAM59B -0.6 -7.76 -0.39 1.07e-13 Gut microbiome composition (summer); CRC cis rs172166 0.561 rs149976 chr6:27987776 C/T cg25164649 chr6:28176230 NA -0.47 -6.87 -0.35 3.25e-11 Cardiac Troponin-T levels; CRC cis rs7618915 0.501 rs3852066 chr3:52621839 C/T cg08222913 chr3:52553049 STAB1 -0.34 -6.35 -0.33 7.09e-10 Bipolar disorder; CRC cis rs9296092 0.538 rs9461881 chr6:33520041 C/T cg13560919 chr6:33536144 NA -0.44 -6.2 -0.32 1.71e-9 Age at smoking initiation in chronic obstructive pulmonary disease; CRC cis rs372883 0.600 rs407712 chr21:30722531 G/A cg24692254 chr21:30365293 RNF160 -0.65 -9.76 -0.47 6.43e-20 Pancreatic cancer; CRC cis rs561341 1.000 rs2470243 chr17:30290955 C/T cg19193384 chr17:30244184 NA -0.65 -7.5 -0.38 6.06e-13 Hip circumference adjusted for BMI; CRC cis rs7937682 0.889 rs12360825 chr11:111528786 A/T cg09085632 chr11:111637200 PPP2R1B -1.01 -20.28 -0.75 6.78e-60 Primary sclerosing cholangitis; CRC cis rs7973719 1.000 rs12828040 chr12:7326541 T/C cg07052231 chr12:7363540 PEX5 0.49 7.99 0.4 2.26e-14 IgG glycosylation; CRC cis rs7914558 0.933 rs10883814 chr10:104737404 T/C cg04362960 chr10:104952993 NT5C2 0.63 9.52 0.46 3.81e-19 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC trans rs12155874 0.774 rs13252664 chr8:13971870 C/T cg09567732 chr5:177631413 HNRNPAB 0.47 6.35 0.33 7.27e-10 Intelligence (multi-trait analysis); CRC cis rs8077889 0.917 rs4793038 chr17:41916761 A/T cg16892393 chr17:41919603 NA 0.44 6.77 0.35 5.89e-11 Triglycerides; CRC cis rs731174 0.797 rs679742 chr1:38156190 C/G cg06917450 chr1:38156652 C1orf109 -0.51 -7.09 -0.36 8.17e-12 Prostate cancer (SNP x SNP interaction); CRC cis rs7020830 0.825 rs13297152 chr9:37075623 C/T cg14294708 chr9:37120828 ZCCHC7 1.16 22.33 0.78 6.82e-68 Schizophrenia; CRC cis rs10504229 0.683 rs11786074 chr8:58133532 A/G cg21724239 chr8:58056113 NA 0.49 6.81 0.35 4.75e-11 Developmental language disorder (linguistic errors); CRC cis rs11711311 0.747 rs11928590 chr3:113343478 T/A cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.53 -7.07 -0.36 9.21e-12 IgG glycosylation; CRC cis rs7647973 0.626 rs9830730 chr3:49675875 G/C cg03060546 chr3:49711283 APEH 0.66 7.99 0.4 2.24e-14 Menarche (age at onset); CRC trans rs4263408 0.934 rs9683743 chr4:39703194 A/C cg08045063 chr3:43147672 C3orf39 -0.41 -6.05 -0.32 3.98e-9 Plasma amyloid beta peptide concentrations (ABx-40); CRC cis rs7811142 1.000 rs6972167 chr7:100080013 G/T cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.08 15.33 0.65 2.06e-40 Platelet count; CRC cis rs763121 0.853 rs138712 chr22:39141600 C/T cg06544989 chr22:39130855 UNC84B 0.49 7.07 0.36 9.08e-12 Menopause (age at onset); CRC cis rs3733585 0.699 rs6449158 chr4:9960459 T/C cg00071950 chr4:10020882 SLC2A9 -0.55 -9.79 -0.47 5.05e-20 Cleft plate (environmental tobacco smoke interaction); CRC trans rs208520 0.909 rs55813840 chr6:67012508 A/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.83 9.86 0.48 2.82e-20 Exhaled nitric oxide output; CRC cis rs9914988 1.000 rs9914988 chr17:27183104 G/A cg19196414 chr17:27188595 MIR451;MIR144 -0.39 -5.69 -0.3 2.82e-8 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs3087591 0.801 rs2012535 chr17:29561391 A/T cg24425628 chr17:29625626 OMG;NF1 -0.86 -16.74 -0.68 6.37e-46 Hip circumference; CRC cis rs1799949 0.965 rs4793233 chr17:41435437 G/C cg05368731 chr17:41323189 NBR1 0.67 10.0 0.48 9.66e-21 Menopause (age at onset); CRC trans rs11148252 0.574 rs61958118 chr13:53170226 C/T cg18335740 chr13:41363409 SLC25A15 0.8 14.64 0.63 1.05e-37 Lewy body disease; CRC cis rs8077889 0.672 rs1230397 chr17:41844689 A/G cg26893861 chr17:41843967 DUSP3 1.16 25.71 0.82 1.07e-80 Triglycerides; CRC cis rs9322193 0.923 rs9766004 chr6:150075499 C/T cg07701084 chr6:150067640 NUP43 0.6 9.0 0.44 1.86e-17 Lung cancer; CRC cis rs7818382 1.000 rs7818382 chr8:96054000 C/T cg13393036 chr8:95962371 TP53INP1 -0.5 -8.14 -0.41 8.28e-15 Alzheimer's disease (late onset); CRC trans rs61931739 0.534 rs73103090 chr12:34098801 C/T cg26384229 chr12:38710491 ALG10B 0.53 6.82 0.35 4.24e-11 Morning vs. evening chronotype; CRC cis rs7945705 0.902 rs7479407 chr11:9023421 C/T cg00186954 chr11:8933980 ST5;C11orf17 0.41 6.47 0.34 3.59e-10 Hemoglobin concentration; CRC cis rs6570726 0.764 rs9322028 chr6:145895797 G/T cg05347473 chr6:146136440 FBXO30 0.38 5.85 0.31 1.18e-8 Lobe attachment (rater-scored or self-reported); CRC trans rs1814175 0.715 rs10839409 chr11:49884647 G/T cg11707556 chr5:10655725 ANKRD33B -0.44 -8.28 -0.42 3.06e-15 Height; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg02941859 chr7:99869835 GATS 0.42 6.03 0.32 4.39e-9 Intelligence (multi-trait analysis); CRC cis rs4481887 0.741 rs28468416 chr1:248564451 G/T cg00666640 chr1:248458726 OR2T12 0.39 6.9 0.36 2.61e-11 Common traits (Other); CRC cis rs1348850 0.567 rs1527401 chr2:178522104 C/T cg02961200 chr2:178257176 LOC100130691;AGPS 0.59 8.29 0.42 2.84e-15 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs12474201 0.650 rs56042410 chr2:46914082 A/T cg06386533 chr2:46925753 SOCS5 0.7 8.64 0.43 2.4e-16 Height; CRC cis rs6496667 0.779 rs10520687 chr15:90967749 C/G cg04176472 chr15:90893244 GABARAPL3 -0.55 -7.99 -0.4 2.24e-14 Rheumatoid arthritis; CRC cis rs2749592 0.513 rs1208708 chr10:38085576 A/G cg25427524 chr10:38739819 LOC399744 -0.73 -12.44 -0.57 2.24e-29 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs9381040 0.610 rs6940462 chr6:41020223 G/A cg03644281 chr6:41068752 NFYA;LOC221442 -0.44 -6.37 -0.33 6.31e-10 Alzheimer's disease (late onset); CRC cis rs12497850 0.805 rs6446198 chr3:49007638 T/A cg20833759 chr3:49053208 WDR6;DALRD3 0.54 9.39 0.46 1.06e-18 Parkinson's disease; CRC cis rs1005277 0.541 rs2472177 chr10:38384015 T/G cg17219203 chr10:38645113 HSD17B7P2 -0.41 -5.96 -0.31 6.55e-9 Extrinsic epigenetic age acceleration; CRC cis rs4888262 0.526 rs6564145 chr16:74621129 G/A cg01733217 chr16:74700730 RFWD3 0.79 12.14 0.56 2.89e-28 Testicular germ cell tumor; CRC cis rs13108904 0.870 rs4974543 chr4:1251222 A/G cg00684032 chr4:1343700 KIAA1530 0.46 6.88 0.35 3.02e-11 Obesity-related traits; CRC cis rs6921919 0.583 rs9468368 chr6:28364949 G/A cg21251018 chr6:28226885 NKAPL 0.4 6.06 0.32 3.66e-9 Autism spectrum disorder or schizophrenia; CRC cis rs1552244 0.882 rs113268531 chr3:10167069 A/G cg00166722 chr3:10149974 C3orf24 0.67 8.87 0.44 4.81e-17 Alzheimer's disease; CRC cis rs2455601 0.786 rs3763913 chr11:8951230 C/T cg09997546 chr11:8931473 C11orf17;ST5 -0.5 -6.67 -0.35 1.08e-10 Schizophrenia; CRC cis rs7236492 0.683 rs78250476 chr18:77198934 G/A cg15644404 chr18:77186268 NFATC1 -0.57 -5.87 -0.31 1.07e-8 Inflammatory bowel disease;Crohn's disease; CRC cis rs11123170 0.529 rs112692022 chr2:113970182 C/T cg21482265 chr2:113992762 PAX8;LOC440839;LOC654433 0.51 6.12 0.32 2.6e-9 Renal function-related traits (BUN); CRC cis rs6988985 0.728 rs3753121 chr8:143926380 C/T cg10324643 chr8:143916377 GML -0.41 -6.8 -0.35 4.8e-11 Plasma androstenedione levels in resected early stage-receptor positive breast cancer; CRC cis rs9318086 0.935 rs9553083 chr13:24441525 C/G cg25267304 chr13:24462978 PCOTH;MIPEP -0.58 -9.43 -0.46 7.71e-19 Myopia (pathological); CRC cis rs7927771 0.832 rs11607981 chr11:47401060 T/G cg18512352 chr11:47633146 NA -0.35 -6.84 -0.35 3.98e-11 Subjective well-being; CRC cis rs7552404 0.924 rs1146581 chr1:76213024 T/G cg22875332 chr1:76189707 ACADM 0.7 10.63 0.51 6.78e-23 Blood metabolite levels;Acylcarnitine levels; CRC cis rs908922 0.676 rs11205018 chr1:152496249 T/G cg23254163 chr1:152506842 NA 0.51 10.18 0.49 2.4e-21 Hair morphology; CRC cis rs2576037 0.526 rs6507714 chr18:44519574 A/G cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.68 -10.54 -0.5 1.4e-22 Personality dimensions; CRC cis rs4604732 0.527 rs77361748 chr1:247626475 C/T cg12758973 chr1:247694275 LOC148824;OR2C3 0.42 6.14 0.32 2.32e-9 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CRC cis rs6500602 0.893 rs6500596 chr16:4470027 G/T cg08645402 chr16:4508243 NA 0.55 7.68 0.39 1.81e-13 Schizophrenia; CRC cis rs7208859 0.623 rs60890550 chr17:29030861 A/G cg13385521 chr17:29058706 SUZ12P 0.7 7.85 0.4 6.11e-14 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg15920310 chr18:55297528 NA 0.41 6.79 0.35 5.41e-11 Liver disease severity in Alagille syndrome; CRC trans rs7267979 1.000 rs2258066 chr20:25271326 C/T cg17903999 chr18:56338584 MALT1 -0.41 -6.92 -0.36 2.32e-11 Liver enzyme levels (alkaline phosphatase); CRC cis rs10504229 0.635 rs72649130 chr8:58053810 G/T cg08219700 chr8:58056026 NA 0.59 6.71 0.35 8.27e-11 Developmental language disorder (linguistic errors); CRC cis rs9372498 0.536 rs1319987 chr6:118782236 A/G cg24463073 chr6:118973353 C6orf204 0.52 6.84 0.35 3.84e-11 Diastolic blood pressure; CRC cis rs62244186 0.545 rs7640654 chr3:44763037 A/C cg11003573 chr3:44754125 ZNF502 -0.35 -6.07 -0.32 3.43e-9 Depressive symptoms; CRC cis rs4150161 0.656 rs2288025 chr16:84211735 A/C cg10106505 chr16:84220380 TAF1C -0.93 -7.93 -0.4 3.36e-14 Systolic blood pressure response to hydrochlorothiazide in hypertension; CRC cis rs67311347 0.544 rs9864601 chr3:40345318 C/T cg09455208 chr3:40491958 NA 0.31 6.28 0.33 1.06e-9 Renal cell carcinoma; CRC cis rs6840360 1.000 rs751012 chr4:152602247 A/C cg09659197 chr4:152720779 NA 0.52 11.13 0.52 1.23e-24 Intelligence (multi-trait analysis); CRC cis rs9992667 0.956 rs73232890 chr4:38685041 G/A cg19726192 chr4:38663646 FLJ13197 -0.7 -8.3 -0.42 2.69e-15 Eosinophil percentage of granulocytes; CRC cis rs875971 0.895 rs7788984 chr7:65915616 A/G cg00343986 chr7:65444356 GUSB 0.43 6.12 0.32 2.67e-9 Aortic root size; CRC cis rs13108904 0.539 rs13141169 chr4:1340353 C/T cg02018176 chr4:1364513 KIAA1530 0.4 5.77 0.3 1.82e-8 Obesity-related traits; CRC trans rs2727020 0.734 rs1164663 chr11:49294723 A/T cg15704280 chr7:45808275 SEPT13 0.67 8.83 0.44 6.17e-17 Coronary artery disease; CRC cis rs742115 0.563 rs7762842 chr6:11303695 G/A cg25250968 chr6:11318770 NEDD9 -0.4 -7.67 -0.39 2e-13 Coronary artery disease; CRC trans rs1814175 0.534 rs1983448 chr11:49933856 C/A cg11707556 chr5:10655725 ANKRD33B -0.52 -9.83 -0.48 3.76e-20 Height; CRC cis rs7044106 0.762 rs4142158 chr9:123410819 C/T cg09586646 chr9:123605570 PSMD5;LOC253039 0.63 8.86 0.44 5.29e-17 Hip circumference adjusted for BMI; CRC cis rs7917772 0.629 rs1475646 chr10:104522564 G/T cg22532475 chr10:104410764 TRIM8 0.33 5.62 0.3 4e-8 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC cis rs9649213 0.593 rs736754 chr7:97931559 C/T cg00277769 chr7:97922759 BAIAP2L1 -0.61 -10.74 -0.51 2.85e-23 Prostate cancer (SNP x SNP interaction); CRC cis rs7584330 0.554 rs9646713 chr2:238443542 T/C cg14458575 chr2:238380390 NA 0.53 7.38 0.38 1.29e-12 Prostate cancer; CRC cis rs12760731 0.748 rs10158298 chr1:178470865 G/T cg00404053 chr1:178313656 RASAL2 0.52 5.89 0.31 9.73e-9 Obesity-related traits; CRC trans rs1607741 1.000 rs962227 chr4:72707517 A/G cg06437464 chr6:127441704 RSPO3 0.29 6.11 0.32 2.86e-9 Vitamin D levels; CRC cis rs6502050 0.799 rs6502088 chr17:80169484 C/T cg13198984 chr17:80129470 CCDC57 0.41 7.18 0.37 4.69e-12 Life satisfaction; CRC trans rs7671189 0.502 rs1114552 chr4:11739301 G/A cg18054620 chr5:111191530 C5orf13 -0.3 -6.03 -0.32 4.39e-9 Obesity-related traits; CRC trans rs1814175 0.529 rs1988417 chr11:49932430 A/G cg15704280 chr7:45808275 SEPT13 -0.81 -11.59 -0.54 2.88e-26 Height; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg15048802 chr2:200820651 C2orf60;C2orf47 0.38 6.03 0.32 4.51e-9 Liver disease severity in Alagille syndrome; CRC cis rs4684776 0.676 rs2067471 chr3:11299602 A/G cg00170343 chr3:11313890 ATG7 -0.5 -5.87 -0.31 1.04e-8 Small vessel stroke; CRC cis rs644799 1.000 rs494829 chr11:95571750 C/A cg25622487 chr11:95524042 FAM76B;CEP57 0.76 11.98 0.55 1.12e-27 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs8141529 0.702 rs5762870 chr22:29261159 C/T cg15103426 chr22:29168792 CCDC117 0.5 7.08 0.36 8.65e-12 Lymphocyte counts; CRC cis rs394563 0.901 rs448874 chr6:149796967 C/T cg03678062 chr6:149772716 ZC3H12D -0.35 -6.03 -0.32 4.29e-9 Dupuytren's disease; CRC trans rs10982213 0.830 rs2274163 chr9:117188714 C/T cg09898070 chr2:48009866 MSH6 0.44 7.15 0.37 5.73e-12 Interleukin-6 levels; CRC cis rs6963495 0.818 rs73190155 chr7:105153535 T/A cg02135003 chr7:105160482 PUS7 -0.9 -12.2 -0.56 1.71e-28 Bipolar disorder (body mass index interaction); CRC cis rs2839186 0.814 rs13052376 chr21:47707403 G/C cg09417038 chr21:47716443 C21orf57 -0.42 -6.93 -0.36 2.21e-11 Testicular germ cell tumor; CRC cis rs7949030 0.626 rs7943191 chr11:62328551 A/G cg11742103 chr11:62369870 EML3;MTA2 0.62 11.79 0.54 5.33e-27 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; CRC cis rs6499255 0.951 rs11642030 chr16:69605211 A/C cg04110750 chr16:69646130 NFAT5 -0.55 -7.62 -0.39 2.72e-13 IgE levels; CRC cis rs7927771 0.524 rs754434 chr11:47814280 A/G cg20307385 chr11:47447363 PSMC3 0.46 6.64 0.34 1.33e-10 Subjective well-being; CRC cis rs55788414 0.932 rs55991107 chr16:81181066 G/A cg06400318 chr16:81190750 PKD1L2 -0.66 -6.45 -0.33 4.06e-10 Left ventricular obstructive tract defect (maternal effect); CRC cis rs4713118 0.527 rs4713151 chr6:28136356 G/A cg23161317 chr6:28129485 ZNF389 0.53 6.43 0.33 4.52e-10 Parkinson's disease; CRC cis rs9322193 0.516 rs1999632 chr6:150187873 C/T cg05861140 chr6:150128134 PCMT1 -0.4 -5.67 -0.3 3.05e-8 Lung cancer; CRC cis rs7811142 1.000 rs7809801 chr7:100072031 T/C cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.62 8.09 0.41 1.19e-14 Platelet count; CRC cis rs7605827 0.930 rs7605274 chr2:15604269 A/T cg19274914 chr2:15703543 NA 0.39 5.9 0.31 8.83e-9 Educational attainment (years of education); CRC cis rs9443645 0.527 rs36128361 chr6:79684340 C/G cg05283184 chr6:79620031 NA -0.43 -6.23 -0.32 1.46e-9 Intelligence (multi-trait analysis); CRC cis rs73206853 0.764 rs73191812 chr12:110910279 G/A cg12870014 chr12:110450643 ANKRD13A 0.81 8.45 0.42 9.43e-16 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC cis rs736408 0.527 rs2336147 chr3:52626443 T/C cg07507251 chr3:52567010 NT5DC2 0.45 6.84 0.35 3.93e-11 Bipolar disorder; CRC cis rs1448094 0.967 rs7312144 chr12:86328256 T/C cg18827107 chr12:86230957 RASSF9 -0.37 -6.1 -0.32 2.98e-9 Major depressive disorder; CRC cis rs28386778 0.799 rs2665836 chr17:61898135 C/A cg25654072 chr17:61904446 PSMC5;FTSJ3 0.74 11.52 0.54 4.92e-26 Prudent dietary pattern; CRC cis rs6496667 0.865 rs62019279 chr15:90882334 G/A cg04176472 chr15:90893244 GABARAPL3 0.57 6.62 0.34 1.45e-10 Rheumatoid arthritis; CRC cis rs77633900 0.614 rs280029 chr15:77031235 A/G cg21673338 chr15:77095150 SCAPER -0.71 -6.99 -0.36 1.58e-11 Non-glioblastoma glioma;Glioma; CRC trans rs7824557 0.713 rs6601575 chr8:11097804 A/C cg06636001 chr8:8085503 FLJ10661 0.52 7.83 0.4 6.67e-14 Retinal vascular caliber; CRC cis rs514406 0.929 rs12354395 chr1:53327663 A/G cg25767906 chr1:53392781 SCP2 -0.46 -7.39 -0.38 1.26e-12 Monocyte count; CRC trans rs1814175 0.817 rs10769613 chr11:49769692 G/A cg15704280 chr7:45808275 SEPT13 -0.97 -18.79 -0.72 5.12e-54 Height; CRC cis rs2228479 0.850 rs2238525 chr16:89809902 T/C cg19635926 chr16:89946313 TCF25 0.59 5.8 0.3 1.57e-8 Skin colour saturation; CRC cis rs4780401 0.703 rs3190321 chr16:11773662 C/G cg01061890 chr16:11836724 TXNDC11 -0.47 -6.69 -0.35 9.83e-11 Rheumatoid arthritis; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg13611783 chr6:71377394 SMAP1 0.43 6.13 0.32 2.45e-9 Response to antipsychotic treatment; CRC cis rs2067615 0.579 rs4964489 chr12:107171808 A/G cg13491945 chr12:107078410 RFX4 0.34 5.85 0.31 1.21e-8 Heart rate; CRC cis rs8114671 0.527 rs2295352 chr20:33320055 C/G cg07148914 chr20:33460835 GGT7 -0.38 -5.82 -0.31 1.42e-8 Height; CRC cis rs3736485 0.934 rs11635592 chr15:51859786 A/T cg08986416 chr15:51914746 DMXL2 -0.45 -6.56 -0.34 2.12e-10 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs6952808 0.862 rs4721167 chr7:1933224 C/T cg14004847 chr7:1930337 MAD1L1 -0.42 -5.64 -0.3 3.67e-8 Bipolar disorder and schizophrenia; CRC cis rs1008375 0.686 rs34338142 chr4:17626174 T/A cg16339924 chr4:17578868 LAP3 0.53 6.84 0.35 3.9e-11 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs1150668 0.835 rs1233696 chr6:28143010 T/C cg21251018 chr6:28226885 NKAPL 0.58 10.15 0.49 3.17e-21 Pubertal anthropometrics; CRC cis rs3820068 0.581 rs78175477 chr1:15948091 C/G cg27534772 chr1:16042836 PLEKHM2 0.55 11.0 0.52 3.66e-24 Systolic blood pressure; CRC cis rs9900062 0.546 rs2676289 chr17:62705738 A/G cg02598441 chr17:62777298 LOC146880 0.53 7.13 0.37 6.28e-12 QT interval; CRC cis rs4660306 0.614 rs781057 chr1:45936017 C/G cg03123370 chr1:45965343 CCDC163P;MMACHC 0.49 6.52 0.34 2.59e-10 Homocysteine levels; CRC cis rs9462846 0.821 rs10223860 chr6:42875383 T/G cg21280719 chr6:42927975 GNMT -0.32 -6.21 -0.32 1.61e-9 Blood protein levels; CRC trans rs10242455 0.702 rs17161700 chr7:98977067 A/G cg09045935 chr12:6379348 NA 0.88 6.91 0.36 2.57e-11 Blood metabolite levels; CRC cis rs9788721 0.836 rs17483686 chr15:78733390 A/T cg18825076 chr15:78729989 IREB2 -0.46 -7.15 -0.37 5.73e-12 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio;Emphysema imaging phenotypes;Emphysema distribution in smoking;Local histogram emphysema pattern;Post bronchodilator FEV1/FVC ratio in COPD; CRC cis rs1887596 0.705 rs541816 chr13:27204062 T/G cg01312412 chr13:27282625 NA 0.43 5.67 0.3 3.21e-8 Facial morphology (factor 3, length of philtrum); CRC cis rs919433 1.000 rs7422899 chr2:198163527 G/C cg10820045 chr2:198174542 NA -0.55 -9.34 -0.46 1.53e-18 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC cis rs9517313 0.584 rs9556974 chr13:99216302 G/C cg20487152 chr13:99095054 FARP1 -0.45 -6.5 -0.34 2.99e-10 Neuroticism; CRC cis rs9303401 0.659 rs62083436 chr17:57031742 G/A cg02118635 chr17:56770003 RAD51C;TEX14 0.8 10.12 0.49 3.96e-21 Cognitive test performance; CRC trans rs1814175 0.527 rs7128827 chr11:49665644 C/T cg03929089 chr4:120376271 NA 0.77 10.56 0.5 1.17e-22 Height; CRC cis rs3008870 0.755 rs2815362 chr1:67496803 C/T cg08660285 chr1:67390436 MIER1;WDR78 0.56 7.95 0.4 2.96e-14 Lymphocyte percentage of white cells; CRC cis rs3820068 0.603 rs7529759 chr1:15977877 A/G cg24675056 chr1:15929824 NA 0.54 7.43 0.38 9.67e-13 Systolic blood pressure; CRC cis rs3741151 0.892 rs2027761 chr11:73036179 C/T cg17517138 chr11:73019481 ARHGEF17 0.63 6.68 0.35 1.05e-10 GIP levels in response to oral glucose tolerance test (120 minutes); CRC cis rs9814567 0.806 rs55835132 chr3:134325256 T/G cg06541857 chr3:134203789 ANAPC13;CEP63 -0.37 -5.71 -0.3 2.47e-8 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs1320333 0.772 rs2867116 chr2:682363 C/A cg00500140 chr2:691012 NA 0.63 7.01 0.36 1.37e-11 Obesity-related traits; CRC cis rs10504229 1.000 rs56350499 chr8:58178139 C/T cg02725872 chr8:58115012 NA -0.38 -6.43 -0.33 4.44e-10 Developmental language disorder (linguistic errors); CRC cis rs8067545 0.611 rs2526465 chr17:20167611 T/C cg13482628 chr17:19912719 NA -0.48 -7.62 -0.39 2.73e-13 Schizophrenia; CRC cis rs80207740 1.000 rs17296501 chr8:21849566 C/T cg25597362 chr8:21767310 DOK2 -0.55 -6.66 -0.34 1.14e-10 Mean corpuscular hemoglobin; CRC cis rs539096 0.540 rs3011219 chr1:44306120 A/G cg12908607 chr1:44402522 ARTN -0.51 -9.31 -0.46 1.92e-18 Intelligence (multi-trait analysis); CRC cis rs2019137 0.560 rs7578633 chr2:113978650 C/T cg19083407 chr2:113993142 PAX8;LOC440839;LOC654433 0.61 8.94 0.44 2.96e-17 Lymphocyte counts; CRC trans rs11148252 0.740 rs3803264 chr13:52971893 A/G cg18335740 chr13:41363409 SLC25A15 -0.49 -7.19 -0.37 4.47e-12 Lewy body disease; CRC cis rs6693567 0.565 rs1776275 chr1:150269437 G/T cg15654264 chr1:150340011 RPRD2 -0.4 -5.9 -0.31 8.95e-9 Migraine; CRC cis rs9517320 0.534 rs61969451 chr13:99167654 A/T cg07423050 chr13:99094983 FARP1 -0.56 -8.06 -0.41 1.42e-14 Longevity; CRC cis rs933688 1.000 rs1964292 chr5:90743608 T/C cg02339078 chr5:90679543 LOC100129716;ARRDC3 0.88 13.58 0.6 1.14e-33 Smoking behavior; CRC cis rs875971 0.642 rs35526611 chr7:66094008 C/T cg18876405 chr7:65276391 NA -0.62 -11.15 -0.52 1.04e-24 Aortic root size; CRC cis rs8180040 0.903 rs11710013 chr3:47296921 T/C cg02527881 chr3:46936655 PTH1R -0.41 -7.67 -0.39 1.91e-13 Colorectal cancer; CRC cis rs7666738 0.830 rs13124689 chr4:98961182 A/T cg17366294 chr4:99064904 C4orf37 0.43 7.36 0.38 1.49e-12 Colonoscopy-negative controls vs population controls; CRC cis rs9549328 0.670 rs35992827 chr13:113616752 G/A cg17524180 chr13:113633600 MCF2L 0.5 9.0 0.44 1.86e-17 Systolic blood pressure; CRC cis rs807669 1.000 rs807669 chr22:19154522 T/C cg02655711 chr22:19163373 SLC25A1 0.87 16.53 0.67 4.21e-45 Metabolite levels; CRC cis rs7914558 0.966 rs943035 chr10:104839152 T/C cg15744005 chr10:104629667 AS3MT -0.34 -7.22 -0.37 3.72e-12 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs4481887 0.741 rs6587462 chr1:248539094 C/T cg00666640 chr1:248458726 OR2T12 -0.42 -7.56 -0.38 4.04e-13 Common traits (Other); CRC trans rs11039798 0.588 rs7946443 chr11:48545504 G/A cg03929089 chr4:120376271 NA 0.64 6.66 0.34 1.16e-10 Axial length; CRC trans rs561341 1.000 rs4795667 chr17:30244443 T/C cg27661571 chr11:113659931 NA -0.88 -10.43 -0.5 3.41e-22 Hip circumference adjusted for BMI; CRC cis rs1448094 0.511 rs7976647 chr12:86158766 A/G cg00310523 chr12:86230176 RASSF9 0.38 6.08 0.32 3.31e-9 Major depressive disorder; CRC cis rs8060686 0.920 rs12448923 chr16:67839128 C/T cg07125278 chr16:67683757 RLTPR -0.62 -7.07 -0.36 9.54e-12 HDL cholesterol;Metabolic syndrome; CRC cis rs6570726 0.905 rs377143 chr6:145834220 C/T cg05347473 chr6:146136440 FBXO30 0.37 5.84 0.31 1.25e-8 Lobe attachment (rater-scored or self-reported); CRC cis rs7949030 0.626 rs71490390 chr11:62329185 A/G cg22862634 chr11:62369728 EML3;MTA2 0.58 10.31 0.49 8.7e-22 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; CRC cis rs11758351 0.866 rs56186759 chr6:26207181 C/T cg01420254 chr6:26195488 NA 0.78 9.0 0.44 1.85e-17 Gout;Renal underexcretion gout; CRC cis rs7945718 0.621 rs10831887 chr11:12665436 A/C cg25843174 chr11:12811716 TEAD1 0.41 7.78 0.39 9.5e-14 Educational attainment (years of education); CRC cis rs1129187 0.755 rs3293 chr6:42938377 G/T cg21280719 chr6:42927975 GNMT -0.46 -10.45 -0.5 2.96e-22 Alzheimer's disease in APOE e4+ carriers; CRC cis rs7809950 0.635 rs62483629 chr7:106866178 T/C cg23024343 chr7:107201750 COG5 -0.71 -9.54 -0.47 3.41e-19 Coronary artery disease; CRC cis rs3733585 0.673 rs4560411 chr4:9953361 A/G cg00071950 chr4:10020882 SLC2A9 -0.55 -9.74 -0.47 7.09e-20 Cleft plate (environmental tobacco smoke interaction); CRC trans rs6951245 0.935 rs61910751 chr7:1097895 A/G cg13565492 chr6:43139072 SRF -0.72 -7.44 -0.38 8.63e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs4862750 0.914 rs11943333 chr4:187872455 A/G cg07414643 chr4:187882934 NA 0.37 6.38 0.33 5.89e-10 Lobe attachment (rater-scored or self-reported); CRC cis rs6570726 0.791 rs6570692 chr6:145904401 T/A cg05347473 chr6:146136440 FBXO30 0.38 5.8 0.3 1.54e-8 Lobe attachment (rater-scored or self-reported); CRC cis rs9916302 0.904 rs2338755 chr17:37419317 C/T cg15445000 chr17:37608096 MED1 -0.4 -8.88 -0.44 4.57e-17 Glomerular filtration rate (creatinine); CRC cis rs6662572 0.737 rs4660887 chr1:46275959 A/G cg03123370 chr1:45965343 CCDC163P;MMACHC -0.48 -6.22 -0.32 1.52e-9 Blood protein levels; CRC cis rs10504229 0.545 rs56394419 chr8:58128982 T/C cg02725872 chr8:58115012 NA -0.64 -11.55 -0.54 3.85e-26 Developmental language disorder (linguistic errors); CRC cis rs9309711 0.643 rs4264589 chr2:3481098 G/T cg10845886 chr2:3471009 TTC15 -0.4 -6.32 -0.33 8.58e-10 Neurofibrillary tangles; CRC cis rs10911232 0.507 rs3934579 chr1:183027432 G/A ch.1.3577855R chr1:183094577 LAMC1 0.83 14.62 0.63 1.24e-37 Hypertriglyceridemia; CRC cis rs7666738 0.830 rs11721726 chr4:98996314 T/C cg05340658 chr4:99064831 C4orf37 0.61 9.54 0.47 3.44e-19 Colonoscopy-negative controls vs population controls; CRC cis rs4713118 0.513 rs149944 chr6:28002818 C/T cg02683197 chr6:28174875 NA 0.59 8.33 0.42 2.18e-15 Parkinson's disease; CRC cis rs250677 1.000 rs250677 chr5:148433549 T/C cg23229984 chr5:148520753 ABLIM3 0.48 6.89 0.36 2.84e-11 Breast cancer; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg15564972 chr6:79787561 PHIP 0.41 6.23 0.32 1.41e-9 Intelligence (multi-trait analysis); CRC cis rs11155671 0.530 rs3823021 chr6:150210999 G/C cg07701084 chr6:150067640 NUP43 0.49 7.2 0.37 4.04e-12 Testicular germ cell tumor; CRC cis rs6963495 0.538 rs55967123 chr7:105163678 C/A cg02135003 chr7:105160482 PUS7 -0.9 -12.2 -0.56 1.71e-28 Bipolar disorder (body mass index interaction); CRC cis rs4731207 0.735 rs17147494 chr7:124449835 G/A cg23710748 chr7:124431027 NA 0.37 5.96 0.31 6.53e-9 Cutaneous malignant melanoma; CRC cis rs763121 0.853 rs4821798 chr22:39021165 T/C cg06022373 chr22:39101656 GTPBP1 0.8 13.45 0.6 3.62e-33 Menopause (age at onset); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg17632124 chr6:41040243 C6orf130;NFYA 0.41 6.03 0.32 4.38e-9 Intelligence (multi-trait analysis); CRC cis rs8014204 1.000 rs8014374 chr14:75322914 G/A cg03030879 chr14:75389066 RPS6KL1 0.56 9.02 0.45 1.61e-17 Caffeine consumption; CRC cis rs10504229 0.683 rs17802743 chr8:58105897 C/T cg11062466 chr8:58055876 NA 0.57 7.09 0.36 8.14e-12 Developmental language disorder (linguistic errors); CRC cis rs9322193 0.962 rs2065664 chr6:150083621 A/G cg00933542 chr6:150070202 PCMT1 0.29 5.92 0.31 8.13e-9 Lung cancer; CRC cis rs9916302 0.904 rs679995 chr17:37441679 A/T cg03013999 chr17:37608204 MED1 -0.47 -7.04 -0.36 1.1e-11 Glomerular filtration rate (creatinine); CRC cis rs10927875 0.632 rs2862162 chr1:16142960 A/C cg21385522 chr1:16154831 NA 1.08 18.97 0.72 9.43e-55 Dilated cardiomyopathy; CRC cis rs1387259 0.690 rs1601985 chr12:48761914 A/G cg04545296 chr12:48745243 ZNF641 0.35 6.09 0.32 3.12e-9 Obstructive sleep apnea trait (apnea hypopnea index); CRC cis rs9467711 0.651 rs35402046 chr6:26099472 G/A cg08501292 chr6:25962987 TRIM38 0.64 6.31 0.33 8.99e-10 Autism spectrum disorder or schizophrenia; CRC cis rs7914558 0.966 rs10786745 chr10:104956827 A/G cg15744005 chr10:104629667 AS3MT -0.33 -6.98 -0.36 1.65e-11 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs7674212 0.539 rs7676041 chr4:104126421 T/A cg16532752 chr4:104119610 CENPE -0.42 -6.0 -0.31 5.24e-9 Type 2 diabetes; CRC cis rs7659604 1.000 rs10016433 chr4:122664771 A/G cg06713675 chr4:122721982 EXOSC9 -0.38 -6.19 -0.32 1.76e-9 Type 2 diabetes; CRC cis rs9322193 0.923 rs35967444 chr6:149996724 G/A cg07701084 chr6:150067640 NUP43 0.56 8.14 0.41 8.26e-15 Lung cancer; CRC cis rs55793580 1 rs55793580 chr9:127009395 C/T cg14385362 chr9:127054095 NEK6 0.4 5.61 0.3 4.2e-8 Monocyte percentage of white cells;Granulocyte percentage of myeloid white cells;Monocyte count; CRC cis rs8040855 0.627 rs12904238 chr15:85639841 A/T cg10818794 chr15:86012489 AKAP13 -0.44 -5.97 -0.31 6.09e-9 Bulimia nervosa; CRC cis rs9322193 0.923 rs9505982 chr6:149939601 G/A cg13206674 chr6:150067644 NUP43 0.63 9.49 0.46 4.71e-19 Lung cancer; CRC cis rs116248771 0.549 rs9811858 chr3:158443093 T/C cg16708174 chr3:158430962 RARRES1 0.44 5.8 0.3 1.57e-8 diarrhoeal disease at age 2; CRC trans rs9585327 0.584 rs4772260 chr13:100645723 A/G cg12047218 chr8:125740117 MTSS1 0.36 6.13 0.32 2.54e-9 Myopia; CRC cis rs10486722 0.638 rs10807909 chr7:41796981 T/G cg22138096 chr7:41772439 LOC285954 0.45 5.64 0.3 3.67e-8 Pit-and-Fissure caries; CRC cis rs9814567 0.896 rs6794258 chr3:134344505 G/A cg06109529 chr3:134205091 CEP63;ANAPC13 -0.67 -9.59 -0.47 2.35e-19 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs17376456 0.825 rs13156202 chr5:93157721 C/T cg09848695 chr5:92956644 FAM172A;MIR2277 -0.64 -6.18 -0.32 1.86e-9 Diabetic retinopathy; CRC cis rs10540 0.730 rs61877766 chr11:512973 T/G cg03934478 chr11:495069 RNH1 0.7 7.84 0.4 6.44e-14 Body mass index; CRC cis rs10504229 1.000 rs60651159 chr8:58174074 T/C cg22535103 chr8:58192502 C8orf71 -0.82 -12.27 -0.56 9.63e-29 Developmental language disorder (linguistic errors); CRC cis rs2739330 0.796 rs1006771 chr22:24314006 G/T cg11060661 chr22:24314208 DDT;DDTL 0.4 6.75 0.35 6.74e-11 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs6502050 0.799 rs6502078 chr17:80124364 G/A cg11859384 chr17:80120422 CCDC57 -0.36 -5.75 -0.3 2.06e-8 Life satisfaction; CRC cis rs881375 0.902 rs2900180 chr9:123706382 T/C cg14255062 chr9:123606675 PSMD5;LOC253039 0.41 5.97 0.31 6.3e-9 Rheumatoid arthritis; CRC cis rs7945718 0.621 rs10831895 chr11:12683327 T/C cg25843174 chr11:12811716 TEAD1 0.39 7.17 0.37 4.89e-12 Educational attainment (years of education); CRC cis rs67340775 0.541 rs200968 chr6:27859568 T/C cg25164649 chr6:28176230 NA 0.59 6.02 0.32 4.61e-9 Lung cancer in ever smokers; CRC cis rs921968 0.613 rs1344642 chr2:219555262 G/A cg02176678 chr2:219576539 TTLL4 -0.45 -7.11 -0.37 7.21e-12 Mean corpuscular hemoglobin concentration; CRC cis rs2046867 0.862 rs57396880 chr3:72844785 G/A cg25664220 chr3:72788482 NA -0.47 -6.49 -0.34 3.18e-10 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; CRC cis rs394563 0.591 rs6570964 chr6:149691859 G/A cg16235748 chr6:149772707 ZC3H12D 0.37 6.65 0.34 1.25e-10 Dupuytren's disease; CRC cis rs7527798 0.592 rs2181694 chr1:207826776 G/A cg09232269 chr1:207846808 CR1L -0.48 -7.93 -0.4 3.35e-14 Erythrocyte sedimentation rate; CRC cis rs6831352 0.918 rs29001216 chr4:100051556 A/T cg12011299 chr4:100065546 ADH4 -0.49 -9.27 -0.45 2.61e-18 Alcohol dependence; CRC cis rs6060717 0.654 rs6058347 chr20:34483781 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.56 -8.48 -0.42 7.94e-16 Hip circumference adjusted for BMI; CRC cis rs2153535 0.580 rs718502 chr6:8527400 T/C cg21535247 chr6:8435926 SLC35B3 0.48 7.36 0.38 1.49e-12 Motion sickness; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg17494855 chr1:43855675 C1orf84;MED8 0.4 6.75 0.35 6.5e-11 Liver disease severity in Alagille syndrome; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg11817999 chr17:17655531 RAI1 0.42 6.51 0.34 2.74e-10 Intelligence (multi-trait analysis); CRC cis rs1799949 0.894 rs36062488 chr17:41337472 C/T cg07153921 chr17:41440717 NA 0.38 5.8 0.3 1.54e-8 Menopause (age at onset); CRC cis rs891088 0.660 rs10413831 chr19:7198377 C/T cg09779027 chr19:7224513 INSR -0.53 -6.62 -0.34 1.44e-10 Hip circumference adjusted for BMI;Height; CRC cis rs6693567 0.565 rs696617 chr1:150376311 G/T cg15654264 chr1:150340011 RPRD2 0.42 6.2 0.32 1.68e-9 Migraine; CRC trans rs2303319 0.504 rs62189055 chr2:162625749 C/A cg04551154 chr10:95462393 C10orf4 -0.75 -6.36 -0.33 6.93e-10 Cognitive function; CRC cis rs7107174 0.892 rs10793310 chr11:78099014 T/G cg02023728 chr11:77925099 USP35 0.47 7.25 0.37 2.92e-12 Testicular germ cell tumor; CRC cis rs7512552 0.839 rs832622 chr1:150392830 A/G cg15654264 chr1:150340011 RPRD2 0.58 8.5 0.42 6.79e-16 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); CRC cis rs1348850 0.526 rs2293475 chr2:178407897 C/T cg27490568 chr2:178487706 NA -0.63 -7.28 -0.37 2.42e-12 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC trans rs2832077 0.527 rs2776210 chr21:30268558 A/G cg14791747 chr16:20752902 THUMPD1 -0.67 -10.51 -0.5 1.78e-22 Cognitive test performance; CRC cis rs12541335 0.639 rs7003478 chr8:22201123 A/G cg09517075 chr8:22133004 PIWIL2 0.49 8.51 0.42 6.42e-16 Hypertriglyceridemia; CRC cis rs6952808 0.601 rs3800882 chr7:2120758 G/A cg22963979 chr7:1858916 MAD1L1 -0.39 -5.85 -0.31 1.2e-8 Bipolar disorder and schizophrenia; CRC trans rs6598955 0.671 rs11247909 chr1:26640135 G/A cg07461501 chr17:79650226 HGS;ARL16 -0.54 -6.33 -0.33 8.22e-10 Obesity-related traits; CRC cis rs8060686 0.641 rs7193935 chr16:68071147 C/T cg26727032 chr16:67993705 SLC12A4 -0.6 -8.03 -0.4 1.76e-14 HDL cholesterol;Metabolic syndrome; CRC trans rs3858526 0.920 rs11511938 chr11:5928793 A/G cg01505111 chr6:125621795 HDDC2 0.4 6.42 0.33 4.73e-10 DNA methylation (variation); CRC cis rs290268 1.000 rs290274 chr9:93546913 C/T cg02608019 chr9:93564028 SYK 0.44 6.96 0.36 1.8e-11 Platelet count; CRC cis rs11098499 0.863 rs58452170 chr4:120459674 A/T cg24375607 chr4:120327624 NA 0.48 7.43 0.38 9.4e-13 Corneal astigmatism; CRC cis rs6545883 0.524 rs2593631 chr2:61572286 A/G cg10580144 chr2:61372316 C2orf74 -0.35 -7.81 -0.4 7.8500000000000006e-14 Tuberculosis; CRC cis rs10504229 0.683 rs72650849 chr8:58140323 A/G cg02290350 chr8:58132656 NA -0.58 -8.16 -0.41 7.29e-15 Developmental language disorder (linguistic errors); CRC cis rs17095355 0.818 rs12571549 chr10:111770013 G/A cg00817464 chr10:111662876 XPNPEP1 -0.49 -5.77 -0.3 1.82e-8 Biliary atresia; CRC cis rs713587 0.967 rs6752378 chr2:25150116 C/A cg04586622 chr2:25135609 ADCY3 -0.48 -8.51 -0.42 6.11e-16 Body mass index in non-asthmatics; CRC cis rs7615952 0.551 rs12695470 chr3:125635718 C/A cg05084668 chr3:125655381 ALG1L -0.62 -8.37 -0.42 1.71e-15 Blood pressure (smoking interaction); CRC cis rs6580649 1.000 rs9805048 chr12:48403692 C/T cg05342945 chr12:48394962 COL2A1 -0.39 -5.64 -0.3 3.6e-8 Lung cancer; CRC trans rs7618501 0.966 rs13063621 chr3:49821625 T/C cg21582582 chr3:182698605 DCUN1D1 0.56 8.34 0.42 2.09e-15 Intelligence (multi-trait analysis); CRC cis rs28386778 0.933 rs2665801 chr17:61952100 C/T cg22520471 chr17:61851767 DDX42;CCDC47 0.74 11.47 0.53 7.29e-26 Prudent dietary pattern; CRC cis rs11628318 0.802 rs6575926 chr14:103050183 G/A cg12046867 chr14:103022105 NA -0.83 -11.44 -0.53 9.88e-26 Platelet count; CRC cis rs10769945 0.679 rs2137322 chr11:1917354 A/G cg23202291 chr11:1979235 NA -0.41 -6.01 -0.31 5.06e-9 DNA methylation (variation); CRC cis rs2635047 0.615 rs2576052 chr18:44690107 C/T cg19077165 chr18:44547161 KATNAL2 0.39 5.97 0.31 6.24e-9 Educational attainment; CRC cis rs9488822 0.676 rs11757115 chr6:116362619 C/T cg15226275 chr6:116381976 FRK 0.31 8.79 0.44 8.52e-17 Cholesterol, total;LDL cholesterol; CRC cis rs2735413 0.958 rs11150034 chr16:78066369 G/A cg04733911 chr16:78082701 NA -0.37 -6.03 -0.32 4.33e-9 Systolic blood pressure (alcohol consumption interaction); CRC cis rs9916302 0.904 rs2338755 chr17:37419317 C/T cg03013999 chr17:37608204 MED1 -0.48 -7.42 -0.38 9.98e-13 Glomerular filtration rate (creatinine); CRC cis rs1003719 0.680 rs2257091 chr21:38522618 G/T cg10648535 chr21:38446584 PIGP;TTC3 -0.49 -6.89 -0.36 2.87e-11 Eye color traits; CRC cis rs10242455 0.702 rs73711280 chr7:99039604 C/T cg18809830 chr7:99032528 PTCD1 -1.03 -7.68 -0.39 1.85e-13 Blood metabolite levels; CRC trans rs2303319 0.504 rs62189052 chr2:162623869 C/G cg13490827 chr1:46269305 MAST2 -0.68 -5.99 -0.31 5.44e-9 Cognitive function; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg23394480 chr14:105487615 CDCA4 0.37 5.97 0.31 6.21e-9 Liver disease severity in Alagille syndrome; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg13909320 chr9:125026858 MRRF;RBM18 0.39 6.07 0.32 3.43e-9 Liver disease severity in Alagille syndrome; CRC cis rs11758351 1.000 rs80095925 chr6:26184942 C/T cg08260959 chr6:26240920 HIST1H4F -0.41 -6.04 -0.32 4.18e-9 Gout;Renal underexcretion gout; CRC cis rs10504229 0.683 rs17194487 chr8:58104912 C/T cg11062466 chr8:58055876 NA 0.56 6.92 0.36 2.3e-11 Developmental language disorder (linguistic errors); CRC cis rs1552244 0.554 rs2272121 chr3:10047680 A/G cg02579736 chr3:10068473 FANCD2;CIDECP 0.67 9.35 0.46 1.38e-18 Alzheimer's disease; CRC cis rs7833790 0.963 rs6473312 chr8:82732515 C/A cg27398817 chr8:82754497 SNX16 -0.53 -6.5 -0.34 2.92e-10 Diastolic blood pressure; CRC cis rs2836974 0.865 rs34778912 chr21:40667037 T/G cg11644478 chr21:40555479 PSMG1 0.78 11.66 0.54 1.58e-26 Cognitive function; CRC cis rs7209700 0.708 rs2292699 chr17:45362295 A/G cg08085267 chr17:45401833 C17orf57 -0.47 -6.97 -0.36 1.73e-11 IgG glycosylation; CRC cis rs9443645 0.838 rs946022 chr6:79672133 G/T cg09184832 chr6:79620586 NA -0.51 -9.41 -0.46 9.04e-19 Intelligence (multi-trait analysis); CRC cis rs950169 0.922 rs2033284 chr15:84946273 C/T cg11189052 chr15:85197271 WDR73 0.63 8.8 0.44 7.99e-17 Schizophrenia; CRC trans rs2303319 0.504 rs35304298 chr2:162617185 G/T cg23919916 chr10:103825097 HPS6 -0.69 -5.99 -0.31 5.54e-9 Cognitive function; CRC cis rs12541335 0.639 rs6993855 chr8:22163797 A/G cg02788857 chr8:22132959 PIWIL2 0.52 9.3 0.46 1.96e-18 Hypertriglyceridemia; CRC cis rs780096 0.526 rs12476704 chr2:27613031 C/A cg12000995 chr2:27665139 KRTCAP3 -0.3 -6.1 -0.32 3.04e-9 Total body bone mineral density; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg06731162 chr10:75173949 ANXA7 0.43 5.97 0.31 5.99e-9 Response to antipsychotic treatment; CRC cis rs7914558 1.000 rs6584540 chr10:104927634 A/G cg15744005 chr10:104629667 AS3MT -0.34 -7.32 -0.37 1.97e-12 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs9486719 1.000 rs12190507 chr6:96898265 T/G cg06623918 chr6:96969491 KIAA0776 -0.81 -9.47 -0.46 5.55e-19 Migraine;Coronary artery disease; CRC cis rs711245 0.573 rs7570763 chr2:36800589 A/C cg09467607 chr2:36825704 FEZ2 -0.54 -8.39 -0.42 1.46e-15 Height; CRC cis rs6433857 0.505 rs1542036 chr2:181350009 A/C cg23363182 chr2:181467187 NA -0.54 -8.14 -0.41 8.3e-15 Body mass index; CRC cis rs7615952 0.599 rs67575510 chr3:125742355 C/G cg06494592 chr3:125709126 NA -0.55 -6.43 -0.33 4.43e-10 Blood pressure (smoking interaction); CRC cis rs2832191 0.740 rs6516890 chr21:30476812 T/A cg08807101 chr21:30365312 RNF160 0.64 10.28 0.49 1.11e-21 Dental caries; CRC cis rs6976053 0.541 rs314359 chr7:100411278 T/C cg20848291 chr7:100343083 ZAN 0.4 6.19 0.32 1.83e-9 Plasminogen activator inhibitor type 1 levels (PAI-1); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg20712274 chr19:9946111 PIN1 0.39 6.02 0.31 4.6e-9 Intelligence (multi-trait analysis); CRC cis rs7493 1.000 rs7786401 chr7:95034001 G/T cg19678392 chr7:94953810 PON1 -0.6 -7.5 -0.38 6.07e-13 Yu-Zhi constitution type in type 2 diabetes; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg16872918 chr9:101558330 ANKS6 0.49 6.38 0.33 5.91e-10 Thyroid stimulating hormone; CRC cis rs11098499 0.662 rs13108589 chr4:120268102 G/C cg09307838 chr4:120376055 NA 0.63 9.56 0.47 2.79e-19 Corneal astigmatism; CRC cis rs10751667 0.961 rs6597951 chr11:991530 C/T cg23136738 chr11:925521 AP2A2 -0.48 -7.66 -0.39 2.15e-13 Alzheimer's disease (late onset); CRC cis rs2795502 0.766 rs947549 chr10:43265880 G/C cg13590978 chr10:43134234 ZNF33B 0.71 5.64 0.3 3.71e-8 Blood protein levels; CRC cis rs2737618 0.651 rs2816974 chr1:200082686 C/G cg21825944 chr1:200113062 NR5A2 0.49 7.09 0.36 8.28e-12 Uric acid levels; CRC cis rs7618915 0.547 rs11720432 chr3:52672742 T/C cg11645453 chr3:52864694 ITIH4 0.37 6.44 0.33 4.2e-10 Bipolar disorder; CRC trans rs3780486 0.846 rs7849148 chr9:33138352 A/T cg04842962 chr6:43655489 MRPS18A 1.16 23.69 0.79 4.09e-73 IgG glycosylation; CRC cis rs72634258 0.554 rs13306061 chr1:7913445 C/T cg26816564 chr1:7831052 VAMP3 0.76 8.65 0.43 2.26e-16 Inflammatory bowel disease; CRC cis rs9322193 0.923 rs14314 chr6:150141531 A/C cg07701084 chr6:150067640 NUP43 0.48 6.71 0.35 8.29e-11 Lung cancer; CRC cis rs1153858 0.895 rs12593402 chr15:45617392 G/A cg21132104 chr15:45694354 SPATA5L1 0.6 8.45 0.42 9.39e-16 Homoarginine levels; CRC cis rs1375194 0.558 rs13418410 chr2:33800899 C/A cg04131969 chr2:33951647 MYADML -0.49 -7.24 -0.37 3.17e-12 Response to antidepressants in depression; CRC cis rs1267303 0.642 rs114746843 chr1:46999239 C/A cg25110126 chr1:46999211 NA 0.6 8.76 0.44 1.02e-16 Monobrow; CRC cis rs7909074 0.714 rs10900129 chr10:45398609 G/C cg05187965 chr10:45406764 TMEM72 -0.3 -6.38 -0.33 6.1e-10 Mean corpuscular volume; CRC cis rs853679 0.517 rs3757187 chr6:28107654 T/C cg21251018 chr6:28226885 NKAPL 0.48 6.33 0.33 7.86e-10 Depression; CRC cis rs9487051 1.000 rs6568569 chr6:109613196 C/A cg12927641 chr6:109611667 NA -0.33 -5.62 -0.3 4.16e-8 Reticulocyte fraction of red cells; CRC cis rs1448094 0.967 rs1374995 chr12:86341764 A/G cg19622623 chr12:86230825 RASSF9 -0.36 -5.81 -0.3 1.51e-8 Major depressive disorder; CRC cis rs11098499 0.562 rs13101722 chr4:120555975 C/A cg24375607 chr4:120327624 NA -0.41 -6.47 -0.34 3.58e-10 Corneal astigmatism; CRC trans rs11098499 0.954 rs59866101 chr4:120296591 T/G cg25214090 chr10:38739885 LOC399744 0.62 9.74 0.47 7.35e-20 Corneal astigmatism; CRC trans rs12599106 0.709 rs1501462 chr16:34964515 A/T cg07332563 chr6:291687 DUSP22 -0.6 -8.67 -0.43 1.96e-16 Menopause (age at onset); CRC cis rs780096 0.506 rs1728922 chr2:27644464 A/C cg12000995 chr2:27665139 KRTCAP3 -0.31 -6.48 -0.34 3.31e-10 Total body bone mineral density; CRC cis rs1448094 0.781 rs7959093 chr12:86335502 C/A cg00310523 chr12:86230176 RASSF9 0.43 7.32 0.37 1.97e-12 Major depressive disorder; CRC trans rs11098499 0.863 rs3775858 chr4:120486028 A/G cg25214090 chr10:38739885 LOC399744 0.67 10.46 0.5 2.59e-22 Corneal astigmatism; CRC cis rs67311347 1.000 rs11914297 chr3:40410070 T/C cg09455208 chr3:40491958 NA 0.43 8.65 0.43 2.24e-16 Renal cell carcinoma; CRC cis rs2274273 0.624 rs7152390 chr14:55811701 C/T cg10130446 chr14:55658398 DLGAP5 -0.42 -5.82 -0.31 1.4e-8 Protein biomarker; CRC cis rs8060686 0.920 rs73593810 chr16:67866783 C/T cg19582491 chr16:67682965 RLTPR -0.58 -6.89 -0.36 2.81e-11 HDL cholesterol;Metabolic syndrome; CRC cis rs709400 0.628 rs11621510 chr14:103869620 T/C cg12935359 chr14:103987150 CKB -0.54 -8.22 -0.41 4.73e-15 Body mass index; CRC cis rs7647973 0.580 rs12629759 chr3:49237394 T/C cg07636037 chr3:49044803 WDR6 0.81 12.32 0.56 6.11e-29 Menarche (age at onset); CRC cis rs875971 1.000 rs7801282 chr7:65613687 C/T cg18912574 chr7:65842487 NCRNA00174 -0.37 -6.4 -0.33 5.31e-10 Aortic root size; CRC cis rs739401 0.611 rs494427 chr11:3048140 A/G cg08508325 chr11:3079039 CARS -0.51 -9.52 -0.46 3.91e-19 Longevity; CRC cis rs11997175 0.967 rs60586868 chr8:33776585 A/G cg04338863 chr8:33670619 NA 0.36 5.77 0.3 1.81e-8 Body mass index; CRC cis rs3008870 0.755 rs2755271 chr1:67474977 C/T cg08660285 chr1:67390436 MIER1;WDR78 0.54 7.57 0.39 3.83e-13 Lymphocyte percentage of white cells; CRC cis rs2836974 0.583 rs2776306 chr21:40713754 A/G cg17971929 chr21:40555470 PSMG1 0.53 7.56 0.38 3.97e-13 Cognitive function; CRC trans rs2303319 0.504 rs2020027 chr2:162425878 C/T cg19471553 chr17:41393123 NA -0.65 -6.04 -0.32 4.15e-9 Cognitive function; CRC cis rs4665809 0.531 rs10199898 chr2:26445485 T/G cg26119090 chr2:26468346 HADHA;HADHB -1.06 -15.5 -0.65 4.69e-41 Gut microbiome composition (summer); CRC cis rs56114371 0.777 rs200481 chr6:27773832 A/T cg23259851 chr6:27775964 HIST1H2AI;HIST1H2BL 0.68 5.99 0.31 5.43e-9 Breast cancer; CRC cis rs12760731 0.623 rs12038759 chr1:178262700 A/C cg00404053 chr1:178313656 RASAL2 0.69 8.84 0.44 5.95e-17 Obesity-related traits; CRC cis rs6964587 0.869 rs7812219 chr7:91545727 C/T cg17063962 chr7:91808500 NA -0.76 -12.77 -0.58 1.31e-30 Breast cancer; CRC cis rs9467711 0.659 rs35433030 chr6:26529890 G/A cg12315302 chr6:26189340 HIST1H4D 0.99 6.93 0.36 2.22e-11 Autism spectrum disorder or schizophrenia; CRC cis rs2046867 0.862 rs62251653 chr3:72811827 C/T cg25664220 chr3:72788482 NA -0.47 -6.57 -0.34 1.94e-10 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; CRC cis rs2243480 1.000 rs34974928 chr7:65364006 T/C cg12463550 chr7:65579703 CRCP 0.65 6.08 0.32 3.28e-9 Diabetic kidney disease; CRC cis rs6594499 0.872 rs10038177 chr5:110436450 C/T cg04022379 chr5:110408740 TSLP 0.47 7.3 0.37 2.17e-12 Allergic disease (asthma, hay fever or eczema); CRC cis rs921968 0.565 rs6757772 chr2:219618497 T/G cg02176678 chr2:219576539 TTLL4 -0.4 -6.4 -0.33 5.42e-10 Mean corpuscular hemoglobin concentration; CRC cis rs2249694 0.919 rs7093170 chr10:135402904 C/T cg20169779 chr10:135381914 SYCE1 -0.64 -10.76 -0.51 2.42e-23 Obesity-related traits; CRC cis rs1129187 0.967 rs9462857 chr6:42943098 T/C cg26304593 chr6:42947056 PEX6 -0.4 -5.73 -0.3 2.22e-8 Alzheimer's disease in APOE e4+ carriers; CRC trans rs61931739 0.500 rs11053222 chr12:34481100 C/A cg26384229 chr12:38710491 ALG10B 0.67 8.79 0.44 8.42e-17 Morning vs. evening chronotype; CRC cis rs2239547 0.522 rs9846976 chr3:53007995 T/C cg18404041 chr3:52824283 ITIH1 -0.35 -6.54 -0.34 2.38e-10 Schizophrenia; CRC cis rs951366 0.789 rs823152 chr1:205736285 G/A cg17178900 chr1:205818956 PM20D1 0.71 10.51 0.5 1.74e-22 Menarche (age at onset); CRC trans rs116095464 0.850 rs10055295 chr5:243749 G/A cg00938859 chr5:1591904 SDHAP3 0.72 7.76 0.39 1.09e-13 Breast cancer; CRC cis rs4713118 0.955 rs9380011 chr6:27683924 A/G cg06470822 chr6:28175283 NA 0.67 9.07 0.45 1.1e-17 Parkinson's disease; CRC cis rs1799949 1.000 rs11653069 chr17:41283377 C/T cg23758822 chr17:41437982 NA 0.79 13.46 0.6 3.47e-33 Menopause (age at onset); CRC cis rs7572644 0.640 rs4555299 chr2:28071190 A/G cg27432699 chr2:27873401 GPN1 0.45 6.22 0.32 1.48e-9 Response to carboplatin and paclitaxel in ovarian cancer (Caspase 3/7 EC50); CRC cis rs1568889 1.000 rs33937991 chr11:28045260 A/G cg06544937 chr11:28130018 METT5D1;KIF18A 0.8 11.42 0.53 1.15e-25 Bipolar disorder; CRC cis rs7914558 1.000 rs943038 chr10:104826261 T/C cg04362960 chr10:104952993 NT5C2 0.6 9.14 0.45 6.57e-18 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs875971 0.929 rs6970860 chr7:65976634 A/G cg00343986 chr7:65444356 GUSB 0.44 6.47 0.34 3.56e-10 Aortic root size; CRC trans rs10983614 1.000 rs7867776 chr9:120072627 A/G cg05301818 chr8:125385252 TMEM65 0.48 6.49 0.34 3.15e-10 Survival in pancreatic cancer; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg09636849 chr2:96658648 NA 0.52 6.67 0.35 1.09e-10 Thyroid stimulating hormone; CRC cis rs4713118 0.513 rs149955 chr6:28036225 G/C cg15845792 chr6:28175446 NA 0.76 11.18 0.52 8.44e-25 Parkinson's disease; CRC cis rs3820068 0.581 rs16851876 chr1:15950628 A/T cg13390004 chr1:15929781 NA -0.52 -7.53 -0.38 4.95e-13 Systolic blood pressure; CRC cis rs561341 0.883 rs4795661 chr17:30201774 T/A cg13647721 chr17:30228624 UTP6 -0.57 -5.9 -0.31 9.26e-9 Hip circumference adjusted for BMI; CRC cis rs7762018 0.655 rs2184195 chr6:170148397 C/T cg24289452 chr6:170231220 NA -0.57 -6.39 -0.33 5.75e-10 Thiazide-induced adverse metabolic effects in hypertensive patients; CRC trans rs2303319 0.504 rs56026147 chr2:162614089 T/C cg03774468 chr3:140950104 ACPL2 -0.65 -6.07 -0.32 3.61e-9 Cognitive function; CRC trans rs4689592 0.513 rs2358718 chr4:7068743 A/C cg07817883 chr1:32538562 TMEM39B 0.59 7.32 0.37 1.95e-12 Monocyte percentage of white cells; CRC cis rs6502050 0.731 rs9892653 chr17:80100191 G/T cg22110888 chr17:80059540 CCDC57 0.4 6.44 0.33 4.17e-10 Life satisfaction; CRC cis rs853679 0.517 rs4711164 chr6:28115156 C/T cg21251018 chr6:28226885 NKAPL 0.48 6.17 0.32 2.02e-9 Depression; CRC cis rs9399137 0.507 rs6940878 chr6:135366309 G/A cg24558204 chr6:135376177 HBS1L 0.6 8.81 0.44 7.43e-17 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; CRC cis rs12618769 0.652 rs3203856 chr2:99226021 C/T cg18455616 chr2:99124870 INPP4A 0.36 5.96 0.31 6.63e-9 Bipolar disorder; CRC trans rs1814175 0.588 rs1721994 chr11:49914050 G/A cg11707556 chr5:10655725 ANKRD33B -0.52 -9.95 -0.48 1.49e-20 Height; CRC cis rs4973397 0.774 rs12998237 chr2:232276651 T/C cg18859089 chr2:232277014 NA 0.43 5.69 0.3 2.75e-8 Anti-saccade response; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg08541953 chr1:6259338 RPL22 0.44 6.21 0.32 1.63e-9 Response to antipsychotic treatment; CRC trans rs75246769 0.925 rs11971144 chr7:145647472 T/C cg21982490 chr5:124845866 NA -0.66 -6.12 -0.32 2.72e-9 Facial morphology (factor 10, width of nasal floor); CRC cis rs929354 0.772 rs3802124 chr7:156970609 G/A cg05182265 chr7:156933206 UBE3C -0.76 -14.38 -0.62 1.04e-36 Body mass index; CRC cis rs2898681 0.519 rs7670068 chr4:53733984 T/G cg00791764 chr4:53727839 RASL11B 0.49 6.55 0.34 2.15e-10 Optic nerve measurement (cup area); CRC trans rs7267979 1.000 rs2500436 chr20:25406366 G/C cg17903999 chr18:56338584 MALT1 0.42 6.97 0.36 1.75e-11 Liver enzyme levels (alkaline phosphatase); CRC cis rs9399137 0.507 rs6940258 chr6:135366132 C/T cg24558204 chr6:135376177 HBS1L 0.59 8.81 0.44 7.33e-17 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; CRC cis rs6964587 0.967 rs41371748 chr7:91708219 A/G cg17063962 chr7:91808500 NA 0.75 11.02 0.52 3.09e-24 Breast cancer; CRC cis rs1816752 1.000 rs9507341 chr13:25006578 G/T cg02811702 chr13:24901961 NA -0.44 -6.15 -0.32 2.3e-9 Obesity-related traits; CRC cis rs7274811 0.711 rs291691 chr20:32002878 G/C cg07470512 chr20:32255052 NECAB3;C20orf134 0.43 5.89 0.31 9.59e-9 Height; CRC cis rs7103648 0.838 rs2293576 chr11:47434986 A/G cg20307385 chr11:47447363 PSMC3 -0.89 -13.37 -0.59 7.34e-33 Diastolic blood pressure;Systolic blood pressure; CRC cis rs3815700 1.000 rs10407204 chr19:33097353 C/T cg02997394 chr19:33096574 ANKRD27 0.75 8.75 0.43 1.14e-16 Eosinophilic esophagitis; CRC cis rs6694672 0.867 rs6656448 chr1:197143278 C/T cg13682187 chr1:196946512 CFHR5 0.46 7.25 0.37 3.09e-12 Asthma; CRC cis rs7208859 0.524 rs28760584 chr17:29141017 G/A cg01831904 chr17:28903510 LRRC37B2 -0.62 -6.41 -0.33 5.13e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs2522056 0.808 rs7704457 chr5:131744790 C/T cg24060327 chr5:131705240 SLC22A5 -0.5 -6.75 -0.35 6.49e-11 Lymphocyte counts;Fibrinogen; CRC cis rs1570884 0.516 rs7330830 chr13:50167929 T/A cg02321871 chr13:50159138 RCBTB1 -0.42 -6.02 -0.32 4.62e-9 Sum basophil neutrophil counts;Sum neutrophil eosinophil counts;Neutrophil count;Myeloid white cell count;Granulocyte count; CRC trans rs10838798 0.504 rs11039627 chr11:48293931 C/T cg21153622 chr11:89784906 NA -0.51 -8.41 -0.42 1.28e-15 Height; CRC cis rs6424115 0.830 rs4649124 chr1:24201357 A/G cg15997130 chr1:24165203 NA 0.73 10.74 0.51 2.79e-23 Immature fraction of reticulocytes; CRC cis rs6502050 0.799 rs8069827 chr17:80089168 C/T cg11859384 chr17:80120422 CCDC57 -0.37 -5.92 -0.31 7.94e-9 Life satisfaction; CRC cis rs1799949 1.000 rs8176220 chr17:41222462 A/G cg19454999 chr17:41278357 BRCA1;NBR2 0.54 8.46 0.42 8.99e-16 Menopause (age at onset); CRC cis rs2032447 0.639 rs198810 chr6:26128618 A/G cg18357526 chr6:26021779 HIST1H4A -0.7 -10.33 -0.49 7.33e-22 Intelligence (multi-trait analysis); CRC cis rs727563 0.638 rs5996058 chr22:42141452 A/G cg06481639 chr22:41940642 POLR3H 0.55 6.17 0.32 1.98e-9 Crohn's disease;Inflammatory bowel disease; CRC cis rs853679 0.517 rs9368557 chr6:28131537 T/C cg03623178 chr6:28175578 NA 0.98 12.66 0.57 3.31e-30 Depression; CRC cis rs13082711 0.555 rs73038733 chr3:27263537 C/G cg02860705 chr3:27208620 NA 0.67 9.02 0.45 1.59e-17 Systolic blood pressure;Diastolic blood pressure;Blood pressure; CRC cis rs6735179 0.837 rs6745451 chr2:1776761 C/T cg26137290 chr2:1776737 NA -0.48 -6.3 -0.33 9.75e-10 Response to antipsychotic treatment; CRC cis rs854572 1.000 rs854572 chr7:94954696 C/G cg07404485 chr7:94953653 PON1 -0.61 -10.59 -0.5 9.83e-23 Paraoxonase activity; CRC cis rs10789491 1.000 rs1258061 chr1:47105000 G/A cg15501359 chr1:47185051 KIAA0494 -0.68 -8.2 -0.41 5.35e-15 Response to hepatitis C treatment; CRC cis rs6089584 0.888 rs6061405 chr20:60617033 A/G cg18761221 chr20:60518478 NA 0.46 7.58 0.39 3.55e-13 Body mass index; CRC cis rs28386778 0.901 rs2854194 chr17:61952110 T/G cg11494091 chr17:61959527 GH2 0.61 10.44 0.5 3.2e-22 Prudent dietary pattern; CRC cis rs314370 0.855 rs17883557 chr7:100494949 G/T cg10426581 chr7:100472382 SRRT 0.62 7.11 0.36 7.24e-12 Resting heart rate; CRC cis rs40363 0.645 rs250631 chr16:3523215 G/C cg21433313 chr16:3507492 NAT15 0.6 8.58 0.43 3.68e-16 Tuberculosis; CRC cis rs9457247 0.565 rs2239823 chr6:167512131 T/C cg07741184 chr6:167504864 NA 0.48 7.95 0.4 3.03e-14 Crohn's disease; CRC cis rs1472147 0.955 rs3736614 chr7:128509048 T/G cg00260937 chr7:128520193 KCP 0.49 7.31 0.37 2.07e-12 Calcium levels; CRC cis rs6502050 0.835 rs3924780 chr17:80112978 G/A cg02741985 chr17:80059408 CCDC57 0.43 7.15 0.37 5.66e-12 Life satisfaction; CRC cis rs10883723 0.738 rs3781290 chr10:104244948 G/C cg04362960 chr10:104952993 NT5C2 -0.41 -5.69 -0.3 2.86e-8 Allergic disease (asthma, hay fever or eczema); CRC cis rs11148252 0.574 rs9536247 chr13:53279542 T/C cg20354231 chr13:53171401 NA -0.46 -7.38 -0.38 1.31e-12 Lewy body disease; CRC cis rs1534166 0.647 rs9853615 chr3:133519981 C/T cg08048268 chr3:133502702 NA -0.39 -6.77 -0.35 5.85e-11 Alcohol consumption (transferrin glycosylation); CRC cis rs4975616 0.714 rs27069 chr5:1347128 C/T cg26373071 chr5:1325741 CLPTM1L 0.44 7.63 0.39 2.57e-13 Lung cancer; CRC cis rs9303401 0.659 rs17222621 chr17:56695923 C/T cg10487724 chr17:56770010 TEX14;RAD51C 0.78 9.69 0.47 1.07e-19 Cognitive test performance; CRC cis rs10504229 0.639 rs67002486 chr8:58117218 A/G cg05313129 chr8:58192883 C8orf71 -0.43 -6.11 -0.32 2.74e-9 Developmental language disorder (linguistic errors); CRC cis rs28386778 0.897 rs2859619 chr17:61917686 T/C cg25654072 chr17:61904446 PSMC5;FTSJ3 0.74 11.42 0.53 1.12e-25 Prudent dietary pattern; CRC cis rs9303280 0.934 rs56380902 chr17:38066372 T/C cg20243544 chr17:37824526 PNMT 0.44 6.69 0.35 9.8e-11 Self-reported allergy; CRC cis rs7659604 1.000 rs28618203 chr4:122663935 T/C cg19748678 chr4:122722346 EXOSC9 0.56 8.89 0.44 4.23e-17 Type 2 diabetes; CRC cis rs950169 0.887 rs3860265 chr15:84945185 C/T cg17507749 chr15:85114479 UBE2QP1 0.74 10.59 0.5 9.91e-23 Schizophrenia; CRC cis rs1801251 0.963 rs13011298 chr2:233612996 A/G cg25237894 chr2:233734115 C2orf82 0.54 8.76 0.44 1.03e-16 Coronary artery disease; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg01719123 chr8:28244050 ZNF395 0.42 6.05 0.32 4.04e-9 Response to antipsychotic treatment; CRC cis rs9291683 0.530 rs882223 chr4:9981625 A/C cg00071950 chr4:10020882 SLC2A9 0.64 11.86 0.55 3.03e-27 Bone mineral density; CRC cis rs2032447 0.670 rs198852 chr6:26104448 A/G cg12310025 chr6:25882481 NA 0.45 6.32 0.33 8.7e-10 Intelligence (multi-trait analysis); CRC cis rs4074493 1.000 rs4075892 chr1:231171807 G/A cg22172038 chr1:231176991 FAM89A 0.35 5.92 0.31 7.89e-9 Carotid plaque burden (smoking interaction); CRC cis rs12477438 0.520 rs6717723 chr2:99756930 T/C cg26064155 chr2:99771622 LIPT1;TSGA10 0.9 16.75 0.68 5.43e-46 Chronic sinus infection; CRC cis rs1707322 1.000 rs11211237 chr1:46447329 G/C cg03146154 chr1:46216737 IPP 0.51 7.06 0.36 1.01e-11 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg05561993 chr7:140373033 ADCK2 0.46 6.41 0.33 5.06e-10 Anxiety disorder; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg26257210 chr1:6305348 HES3 0.43 6.9 0.36 2.62e-11 Liver disease severity in Alagille syndrome; CRC cis rs4588572 0.643 rs1864172 chr5:77690945 T/C cg11547950 chr5:77652471 NA 0.55 7.68 0.39 1.78e-13 Triglycerides; CRC cis rs4819052 0.918 rs34886433 chr21:46680538 G/C cg02159808 chr21:46707872 POFUT2;LOC642852 0.65 7.73 0.39 1.29e-13 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs10256972 0.521 rs10280960 chr7:1103697 A/G cg04025307 chr7:1156635 C7orf50 0.37 5.73 0.3 2.28e-8 Longevity;Endometriosis; CRC cis rs1862618 0.525 rs2662021 chr5:56261691 C/T cg12311346 chr5:56204834 C5orf35 0.81 11.01 0.52 3.33e-24 Initial pursuit acceleration; CRC cis rs853679 0.527 rs853690 chr6:28285482 G/A cg21251018 chr6:28226885 NKAPL 0.53 8.87 0.44 4.63e-17 Depression; CRC cis rs9733 0.628 rs7540874 chr1:150702663 A/C cg10589385 chr1:150898437 SETDB1 0.28 5.96 0.31 6.66e-9 Tonsillectomy; CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg26434548 chr7:129074607 FAM40B 0.38 6.19 0.32 1.79e-9 Obesity-related traits; CRC cis rs28386778 0.897 rs2727328 chr17:61923564 G/A cg07362569 chr17:61921086 SMARCD2 0.37 5.71 0.3 2.47e-8 Prudent dietary pattern; CRC cis rs7772486 0.686 rs6933161 chr6:146081369 G/A cg05347473 chr6:146136440 FBXO30 -0.37 -5.63 -0.3 3.92e-8 Lobe attachment (rater-scored or self-reported); CRC trans rs7313075 0.636 rs79850286 chr12:102471758 T/C cg00456892 chr11:124629925 ESAM -0.41 -5.97 -0.31 6.32e-9 Height; CRC cis rs7412746 0.658 rs897815 chr1:150879101 C/T cg15448220 chr1:150897856 SETDB1 -0.53 -7.79 -0.39 8.94e-14 Melanoma; CRC cis rs7727544 0.735 rs272867 chr5:131681057 G/A cg11843238 chr5:131593191 PDLIM4 0.31 5.7 0.3 2.73e-8 Blood metabolite levels; CRC cis rs4785763 0.570 rs4785759 chr16:90050880 G/T cg08547343 chr16:90038815 CENPBD1;AFG3L1 -0.65 -10.13 -0.49 3.73e-21 Melanoma; CRC cis rs2839186 0.771 rs13046451 chr21:47641373 T/A cg26721908 chr21:47610096 LSS 0.4 6.17 0.32 1.96e-9 Testicular germ cell tumor; CRC cis rs12541635 0.966 rs4734895 chr8:107002604 A/G cg10147462 chr8:107024639 NA 0.45 7.28 0.37 2.44e-12 Age of smoking initiation; CRC cis rs826838 0.709 rs4882355 chr12:38721462 A/T cg26384229 chr12:38710491 ALG10B 0.58 8.57 0.43 4.13e-16 Heart rate; CRC cis rs736408 0.609 rs2230535 chr3:52800284 T/C cg18099408 chr3:52552593 STAB1 -0.45 -7.26 -0.37 2.86e-12 Bipolar disorder; CRC cis rs4664293 0.605 rs6745815 chr2:160550069 C/G cg08347373 chr2:160653686 CD302 0.39 6.52 0.34 2.6200000000000003e-10 Monocyte percentage of white cells; CRC cis rs2075371 1.000 rs2241335 chr7:133979368 C/T cg11752832 chr7:134001865 SLC35B4 0.49 7.5 0.38 5.84e-13 Mean platelet volume; CRC cis rs9325144 0.555 rs1973292 chr12:38679626 T/C cg26384229 chr12:38710491 ALG10B 0.59 8.71 0.43 1.53e-16 Morning vs. evening chronotype; CRC cis rs6748734 1.000 rs6724662 chr2:241831560 A/G cg16358738 chr2:241808595 AGXT -0.39 -5.79 -0.3 1.68e-8 Urinary metabolites; CRC cis rs6952808 0.717 rs6967442 chr7:1926090 A/G cg04267008 chr7:1944627 MAD1L1 -0.64 -9.91 -0.48 2.03e-20 Bipolar disorder and schizophrenia; CRC cis rs4665809 0.627 rs1465720 chr2:26412638 G/T cg27170947 chr2:26402098 FAM59B -0.61 -7.81 -0.4 7.54e-14 Gut microbiome composition (summer); CRC cis rs755249 0.567 rs4660603 chr1:39736334 C/G cg18385671 chr1:39797026 MACF1 0.41 5.83 0.31 1.33e-8 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs775227 0.636 rs3773697 chr3:113023509 C/T cg18753928 chr3:113234510 CCDC52 -0.6 -6.84 -0.35 3.84e-11 Dental caries; CRC cis rs10504229 1.000 rs7007805 chr8:58179327 G/A cg02290350 chr8:58132656 NA -0.42 -5.96 -0.31 6.62e-9 Developmental language disorder (linguistic errors); CRC cis rs875971 1.000 rs2420820 chr7:66091907 T/C cg12463550 chr7:65579703 CRCP -0.47 -6.49 -0.34 3.24e-10 Aortic root size; CRC trans rs1814175 0.645 rs1874969 chr11:49826700 G/A cg15704280 chr7:45808275 SEPT13 -0.94 -16.53 -0.67 4.22e-45 Height; CRC cis rs2836974 0.897 rs2836928 chr21:40543320 C/T cg07074390 chr21:40555500 PSMG1 -0.43 -5.84 -0.31 1.23e-8 Cognitive function; CRC cis rs4332037 0.802 rs73048106 chr7:1929019 G/T cg02421172 chr7:1938701 MAD1L1 0.44 5.94 0.31 7.14e-9 Bipolar disorder; CRC cis rs1448094 0.580 rs11615323 chr12:86282171 T/C cg00310523 chr12:86230176 RASSF9 0.41 6.59 0.34 1.74e-10 Major depressive disorder; CRC cis rs951366 0.789 rs823095 chr1:205679239 G/A cg11965913 chr1:205819406 PM20D1 0.81 12.68 0.57 2.94e-30 Menarche (age at onset); CRC cis rs28374715 0.532 rs11854820 chr15:41676526 G/A cg18705301 chr15:41695430 NDUFAF1 -1.13 -18.76 -0.72 6.3e-54 Ulcerative colitis; CRC cis rs1044826 0.642 rs6787649 chr3:139193321 C/T cg00490450 chr3:139108681 COPB2 0.44 6.59 0.34 1.77e-10 Obesity-related traits; CRC trans rs7647973 0.710 rs11130208 chr3:49615624 G/T cg21665057 chr3:196295764 WDR53;FBXO45 -0.67 -6.94 -0.36 2.13e-11 Menarche (age at onset); CRC cis rs10782582 0.593 rs6675212 chr1:76230829 C/A cg10523679 chr1:76189770 ACADM -0.42 -5.97 -0.31 6.08e-9 Daytime sleep phenotypes; CRC cis rs8072100 0.934 rs8067286 chr17:45594590 A/G cg08085267 chr17:45401833 C17orf57 0.67 10.89 0.51 8.79e-24 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg25722142 chr6:139695762 CITED2 0.48 6.3 0.33 9.5e-10 Thyroid stimulating hormone; CRC trans rs7267979 0.966 rs2261794 chr20:25263062 T/G cg17903999 chr18:56338584 MALT1 -0.41 -6.88 -0.35 3.08e-11 Liver enzyme levels (alkaline phosphatase); CRC trans rs4902562 0.838 rs6573823 chr14:68733632 A/G cg08903604 chr17:2305559 MNT 0.46 5.96 0.31 6.43e-9 Systemic lupus erythematosus; CRC cis rs354033 0.959 rs4727091 chr7:149267704 G/A cg24335155 chr7:149193227 ZNF746 0.37 6.0 0.31 5.18e-9 Multiple sclerosis; CRC cis rs28386778 1.000 rs28386778 chr17:61964815 T/C cg25654072 chr17:61904446 PSMC5;FTSJ3 0.7 10.37 0.5 5.38e-22 Prudent dietary pattern; CRC trans rs7615952 0.546 rs11711150 chr3:125315663 C/T cg16558177 chr4:4109446 NA -0.56 -6.35 -0.33 7.02e-10 Blood pressure (smoking interaction); CRC cis rs9311474 0.713 rs352165 chr3:52242902 A/G cg15147215 chr3:52552868 STAB1 -0.54 -8.89 -0.44 4.25e-17 Electroencephalogram traits; CRC cis rs9287719 0.624 rs6740245 chr2:10760902 T/C cg00105475 chr2:10696890 NA 0.44 6.89 0.36 2.83e-11 Prostate cancer; CRC cis rs10499694 1.000 rs10499694 chr7:50614173 A/G cg14593290 chr7:50529359 DDC -0.44 -6.39 -0.33 5.56e-10 Body mass index; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg20609752 chr19:7894982 EVI5L 0.37 6.02 0.31 4.62e-9 Liver disease severity in Alagille syndrome; CRC cis rs9611565 0.694 rs19573 chr22:41865809 C/A cg06481639 chr22:41940642 POLR3H 0.52 6.49 0.34 3.09e-10 Vitiligo; CRC cis rs11098499 0.644 rs7693919 chr4:120540571 G/A cg09307838 chr4:120376055 NA 0.61 9.25 0.45 2.93e-18 Corneal astigmatism; CRC cis rs4713118 0.527 rs4713151 chr6:28136356 G/A cg12172441 chr6:28176163 NA 0.64 7.53 0.38 5.03e-13 Parkinson's disease; CRC cis rs10504229 0.683 rs2318148 chr8:58114955 G/A cg04204079 chr8:58130323 NA -0.45 -5.83 -0.31 1.34e-8 Developmental language disorder (linguistic errors); CRC cis rs6860806 0.507 rs156322 chr5:131653925 C/T cg04518342 chr5:131593106 PDLIM4 0.42 6.65 0.34 1.19e-10 Breast cancer; CRC cis rs2274273 0.624 rs68138420 chr14:55777967 G/T cg10130446 chr14:55658398 DLGAP5 -0.4 -5.66 -0.3 3.28e-8 Protein biomarker; CRC cis rs7493 0.853 rs2299266 chr7:95049073 A/G cg21856205 chr7:94953877 PON1 -0.51 -6.52 -0.34 2.69e-10 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs6942756 1.000 rs73472312 chr7:128925217 T/C cg02491457 chr7:128862824 NA -0.77 -10.49 -0.5 2.11e-22 White matter hyperintensity burden; CRC cis rs7666738 0.962 rs2865986 chr4:99067907 A/G cg05340658 chr4:99064831 C4orf37 0.53 7.46 0.38 7.87e-13 Colonoscopy-negative controls vs population controls; CRC cis rs9322193 0.884 rs9371201 chr6:150145001 C/T cg13206674 chr6:150067644 NUP43 0.69 9.64 0.47 1.56e-19 Lung cancer; CRC cis rs11098499 0.863 rs1383533 chr4:120434576 G/A cg24375607 chr4:120327624 NA 0.49 7.46 0.38 7.86e-13 Corneal astigmatism; CRC cis rs6952808 0.724 rs7792631 chr7:1982779 C/T cg21782813 chr7:2030301 MAD1L1 0.47 7.6 0.39 3.15e-13 Bipolar disorder and schizophrenia; CRC cis rs9549260 0.785 rs2253001 chr13:41145330 A/T cg21288729 chr13:41239152 FOXO1 0.41 6.35 0.33 7.15e-10 Red blood cell count; CRC cis rs10504229 1.000 rs17216711 chr8:58170856 T/C cg02725872 chr8:58115012 NA -0.38 -6.43 -0.33 4.44e-10 Developmental language disorder (linguistic errors); CRC cis rs4713118 0.513 rs156734 chr6:28007357 A/C cg15786705 chr6:28176104 NA 0.6 8.75 0.43 1.09e-16 Parkinson's disease; CRC cis rs7843479 0.601 rs4872207 chr8:21842751 C/G cg16476235 chr8:21771668 DOK2 -0.38 -6.39 -0.33 5.68e-10 Mean corpuscular volume; CRC cis rs7786877 0.723 rs62482239 chr7:100217810 C/T cg00334542 chr7:100209784 MOSPD3 -0.67 -7.6 -0.39 3.09e-13 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg02636234 chr1:212781466 ATF3 0.49 6.96 0.36 1.87e-11 Response to antipsychotic treatment; CRC cis rs3931020 0.745 rs10874274 chr1:75252134 A/G cg10128416 chr1:75198403 TYW3;CRYZ 0.41 5.66 0.3 3.25e-8 Resistin levels; CRC cis rs4925114 0.568 rs4925109 chr17:17661802 A/G cg09796270 chr17:17721594 SREBF1 -0.53 -9.09 -0.45 9.22e-18 Body mass index; CRC cis rs798554 0.679 rs2644300 chr7:2883071 G/A cg04166393 chr7:2884313 GNA12 0.54 7.42 0.38 1e-12 Height; CRC cis rs12681287 0.640 rs7816629 chr8:87350788 A/T cg27223183 chr8:87520930 FAM82B -0.53 -7.13 -0.37 6.47e-12 Caudate activity during reward; CRC cis rs10540 1.000 rs12419766 chr11:503710 C/T cg03352830 chr11:487213 PTDSS2 0.67 7.71 0.39 1.48e-13 Body mass index; CRC cis rs10504229 1.000 rs17217047 chr8:58180296 G/A cg05313129 chr8:58192883 C8orf71 -0.47 -6.99 -0.36 1.49e-11 Developmental language disorder (linguistic errors); CRC cis rs7998202 0.667 rs99126 chr13:113359336 C/G cg01692110 chr13:113365389 ATP11A 0.51 6.13 0.32 2.56e-9 Glycated hemoglobin levels; CRC cis rs9403521 1.000 rs117303301 chr6:143999003 C/T cg18240653 chr6:144019428 PHACTR2 -0.55 -6.19 -0.32 1.77e-9 Obesity-related traits; CRC cis rs9811920 0.838 rs12488245 chr3:99835254 T/C cg07805332 chr3:99536008 MIR548G;C3orf26 -0.38 -5.81 -0.31 1.46e-8 Axial length; CRC cis rs172166 0.694 rs203877 chr6:28048624 T/C cg03623178 chr6:28175578 NA 0.79 11.69 0.54 1.22e-26 Cardiac Troponin-T levels; CRC cis rs12913538 0.962 rs4775517 chr15:62885173 A/G cg09983546 chr15:62884068 NA 0.63 10.01 0.48 9.15e-21 Sleep depth; CRC cis rs6502050 0.871 rs8066137 chr17:80074316 T/C cg11859384 chr17:80120422 CCDC57 0.37 5.82 0.31 1.43e-8 Life satisfaction; CRC cis rs4713118 0.621 rs4713134 chr6:28034121 T/C cg21251018 chr6:28226885 NKAPL 0.47 6.38 0.33 6.15e-10 Parkinson's disease; CRC cis rs6582630 0.593 rs12816835 chr12:38533304 C/T cg13010199 chr12:38710504 ALG10B -0.44 -6.27 -0.33 1.11e-9 Drug-induced liver injury (flucloxacillin); CRC cis rs338389 0.516 rs6416484 chr15:68312776 T/C cg22576950 chr15:68522787 CLN6 -0.34 -5.8 -0.3 1.53e-8 Survival in rectal cancer; CRC cis rs35146811 0.586 rs1076237 chr7:99585441 A/C cg03265037 chr7:99691720 MIR25;MCM7;MIR106B;MIR93 0.43 5.76 0.3 1.92e-8 Coronary artery disease; CRC cis rs11955398 0.625 rs34395679 chr5:59954716 A/G cg02684056 chr5:59996105 DEPDC1B 0.4 5.83 0.31 1.31e-8 Intelligence (multi-trait analysis); CRC trans rs9467711 0.524 rs13216484 chr6:26762087 C/T cg06606381 chr12:133084897 FBRSL1 -1.08 -7.42 -0.38 1.03e-12 Autism spectrum disorder or schizophrenia; CRC cis rs870825 0.616 rs9631783 chr4:185626511 C/T cg04058563 chr4:185651563 MLF1IP 0.72 9.38 0.46 1.12e-18 Blood protein levels; CRC cis rs9381040 0.655 rs2268192 chr6:41024626 T/C cg03644281 chr6:41068752 NFYA;LOC221442 -0.44 -6.33 -0.33 8.04e-10 Alzheimer's disease (late onset); CRC cis rs7927771 0.756 rs10742803 chr11:47439938 A/G cg05585544 chr11:47624801 NA 0.47 8.55 0.43 4.83e-16 Subjective well-being; CRC trans rs4346635 0.528 rs6835442 chr4:81413207 G/C cg13904968 chr20:56136012 PCK1 -0.18 -5.97 -0.31 6.28e-9 Colonoscopy-negative controls vs population controls; CRC cis rs6499255 1.000 rs8045682 chr16:69786092 C/A cg15192750 chr16:69999425 NA 0.53 6.89 0.35 2.92e-11 IgE levels; CRC cis rs12541635 0.966 rs6469028 chr8:107014552 C/T cg10147462 chr8:107024639 NA 0.41 6.73 0.35 7.62e-11 Age of smoking initiation; CRC cis rs55665837 0.961 rs11023226 chr11:14458817 C/T cg19336497 chr11:14380999 RRAS2 -0.39 -6.64 -0.34 1.33e-10 Vitamin D levels; CRC cis rs2204008 0.837 rs1842599 chr12:37986081 G/A cg26384229 chr12:38710491 ALG10B -0.65 -9.88 -0.48 2.44e-20 Bladder cancer; CRC cis rs6570726 0.791 rs9376953 chr6:145912226 G/T cg23711669 chr6:146136114 FBXO30 0.75 12.89 0.58 4.75e-31 Lobe attachment (rater-scored or self-reported); CRC trans rs2243480 1.000 rs1964692 chr7:65454183 G/A cg10756647 chr7:56101905 PSPH 0.73 7.98 0.4 2.44e-14 Diabetic kidney disease; CRC cis rs7202877 0.706 rs247438 chr16:75432649 C/G cg03315344 chr16:75512273 CHST6 -0.47 -5.61 -0.3 4.29e-8 Type 2 diabetes;Type 1 diabetes; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg08540010 chr20:48770450 TMEM189;TMEM189-UBE2V1 0.4 6.23 0.32 1.41e-9 Intelligence (multi-trait analysis); CRC cis rs9388451 0.839 rs980014 chr6:126068001 T/G cg05901451 chr6:126070800 HEY2 -0.67 -11.62 -0.54 2.26e-26 Brugada syndrome; CRC trans rs9329221 0.868 rs7831557 chr8:10280228 C/T cg08975724 chr8:8085496 FLJ10661 -0.46 -7.15 -0.37 5.76e-12 Neuroticism; CRC cis rs1801251 0.778 rs2250665 chr2:233752639 A/T cg25237894 chr2:233734115 C2orf82 -0.63 -10.88 -0.51 9.62e-24 Coronary artery disease; CRC cis rs34311866 0.808 rs11728344 chr4:963755 T/C cg14530993 chr4:882597 GAK 0.75 6.88 0.35 3.02e-11 Parkinson's disease; CRC cis rs9914988 0.887 rs4795456 chr17:27072463 G/A cg12682573 chr17:27188876 MIR451;MIR144 0.56 7.83 0.4 6.85e-14 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs950027 0.620 rs2486274 chr15:45666228 G/T cg21132104 chr15:45694354 SPATA5L1 0.4 5.8 0.3 1.57e-8 Response to fenofibrate (adiponectin levels); CRC cis rs10504229 0.609 rs56289889 chr8:58116276 G/C cg05313129 chr8:58192883 C8orf71 -0.43 -6.11 -0.32 2.74e-9 Developmental language disorder (linguistic errors); CRC cis rs10463316 0.894 rs10476769 chr5:150763970 A/G cg03212797 chr5:150827313 SLC36A1 -0.5 -7.78 -0.39 9.23e-14 Metabolite levels (Pyroglutamine); CRC cis rs10504229 0.511 rs75967910 chr8:58024231 C/G cg20607798 chr8:58055168 NA 0.51 5.79 0.3 1.66e-8 Developmental language disorder (linguistic errors); CRC cis rs875971 0.545 rs4441996 chr7:65588220 T/C cg02869306 chr7:64672164 INTS4L1 0.43 6.23 0.32 1.41e-9 Aortic root size; CRC cis rs9303401 0.646 rs7217845 chr17:57236900 G/A cg02118635 chr17:56770003 RAD51C;TEX14 0.45 6.89 0.35 2.9e-11 Cognitive test performance; CRC cis rs10504229 0.861 rs114700910 chr8:58170642 C/T cg01721255 chr8:58191610 C8orf71 0.51 6.33 0.33 7.92e-10 Developmental language disorder (linguistic errors); CRC cis rs2243480 1.000 rs34970380 chr7:65431493 C/T cg25985355 chr7:65971099 NA -0.48 -5.75 -0.3 2e-8 Diabetic kidney disease; CRC cis rs4919694 0.808 rs77521106 chr10:104980726 G/T cg04362960 chr10:104952993 NT5C2 1.2 9.69 0.47 1.09e-19 Arsenic metabolism; CRC trans rs1814175 0.817 rs1794164 chr11:49899610 T/C cg15704280 chr7:45808275 SEPT13 -0.97 -18.77 -0.72 6.17e-54 Height; CRC cis rs929354 1.000 rs1182385 chr7:157040583 C/T cg05182265 chr7:156933206 UBE3C 0.73 14.07 0.61 1.56e-35 Body mass index; CRC cis rs12142240 0.698 rs13374893 chr1:46843800 A/G cg00530320 chr1:46809349 NSUN4 0.6 8.14 0.41 8.41e-15 Menopause (age at onset); CRC cis rs1387259 0.931 rs11168474 chr12:48621384 A/C cg04545296 chr12:48745243 ZNF641 0.33 5.73 0.3 2.26e-8 Obstructive sleep apnea trait (apnea hypopnea index); CRC cis rs12597458 0.789 rs7186207 chr16:72035359 C/T cg23815491 chr16:72088622 HP 0.52 8.48 0.42 7.77e-16 Prostate cancer; CRC cis rs4888262 0.604 rs12935075 chr16:74676033 A/T cg01733217 chr16:74700730 RFWD3 0.81 12.33 0.56 5.67e-29 Testicular germ cell tumor; CRC cis rs10208940 0.920 rs6742045 chr2:68811850 G/A cg12452813 chr2:68675892 NA 0.48 6.0 0.31 5.28e-9 Urate levels in lean individuals; CRC cis rs3204270 0.714 rs8074828 chr17:79657136 G/C cg18367735 chr17:79674897 NA 0.48 5.68 0.3 3.04e-8 Dental caries; CRC cis rs1153858 1.000 rs67831559 chr15:45649307 G/T cg10760299 chr15:45669010 GATM 0.49 7.74 0.39 1.23e-13 Homoarginine levels; CRC cis rs7666738 0.830 rs4699331 chr4:99059816 T/C cg17366294 chr4:99064904 C4orf37 0.45 7.71 0.39 1.51e-13 Colonoscopy-negative controls vs population controls; CRC cis rs7412746 0.611 rs10888394 chr1:150749913 C/T cg15448220 chr1:150897856 SETDB1 0.51 7.19 0.37 4.25e-12 Melanoma; CRC cis rs55794721 0.509 rs873308 chr1:25758655 A/G cg20684491 chr1:25596433 NA -0.42 -7.64 -0.39 2.37e-13 Plateletcrit;Mean corpuscular volume; CRC cis rs1046896 0.514 rs67735447 chr17:80823042 G/T cg08200770 chr17:80723486 TBCD -0.49 -7.66 -0.39 2.08e-13 Glycated hemoglobin levels; CRC cis rs2732480 0.557 rs2732484 chr12:48737245 A/C cg21466736 chr12:48725269 NA -0.59 -8.67 -0.43 2.02e-16 Hemoglobin concentration;Red blood cell count;Hematocrit; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg13338022 chr15:43029438 CDAN1 0.49 6.44 0.33 4.26e-10 Thyroid stimulating hormone; CRC cis rs875971 0.862 rs28470208 chr7:65584700 A/G cg18252515 chr7:66147081 NA 0.4 5.77 0.3 1.83e-8 Aortic root size; CRC cis rs2228479 0.717 rs17226274 chr16:89850170 C/T cg06558623 chr16:89946397 TCF25 1.03 9.84 0.48 3.45e-20 Skin colour saturation; CRC cis rs172166 0.694 rs203884 chr6:28077374 G/T cg02683197 chr6:28174875 NA 0.65 9.06 0.45 1.22e-17 Cardiac Troponin-T levels; CRC cis rs2559856 1.000 rs2695281 chr12:102089999 G/A cg12924262 chr12:102091054 CHPT1 0.54 8.03 0.4 1.72e-14 Blood protein levels; CRC cis rs9393692 0.905 rs1124999 chr6:26287043 G/T cg13736514 chr6:26305472 NA -0.61 -11.51 -0.54 5.37e-26 Educational attainment; CRC trans rs875971 0.660 rs2191268 chr7:66110224 C/T cg22012835 chr19:44598275 ZNF224 -0.4 -6.2 -0.32 1.71e-9 Aortic root size; CRC cis rs28386778 0.897 rs2727290 chr17:61894728 G/T cg06601766 chr17:61851465 DDX42;CCDC47 0.44 5.96 0.31 6.33e-9 Prudent dietary pattern; CRC cis rs7618915 0.547 rs13065019 chr3:52685244 T/C cg11645453 chr3:52864694 ITIH4 0.36 6.22 0.32 1.48e-9 Bipolar disorder; CRC cis rs6000550 0.954 rs13055107 chr22:37469821 G/A cg06230247 chr22:37420730 MPST 0.52 5.9 0.31 9.07e-9 Mean corpuscular volume;Mean corpuscular hemoglobin;Red cell distribution width; CRC cis rs3741404 0.825 rs2515241 chr11:63975331 C/T cg18225595 chr11:63971243 STIP1 0.64 10.72 0.51 3.48e-23 Platelet count; CRC cis rs11212617 1.000 rs227088 chr11:108243755 C/T cg14761454 chr11:108092087 ATM;NPAT 0.44 6.58 0.34 1.85e-10 Response to metformin in type 2 diabetes (glycemic); CRC cis rs7703744 0.681 rs3797342 chr5:118691832 C/T cg02283238 chr5:118691126 TNFAIP8 0.45 6.08 0.32 3.35e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs897984 0.609 rs72800847 chr16:31022639 G/A cg00531865 chr16:30841666 NA -0.44 -5.68 -0.3 2.96e-8 Dementia with Lewy bodies; CRC cis rs939584 1.000 rs7608050 chr2:652247 G/A cg03610516 chr2:642275 NA -0.42 -5.77 -0.3 1.82e-8 Body mass index; CRC cis rs10504229 0.773 rs1874373 chr8:58194423 T/C cg01721255 chr8:58191610 C8orf71 0.47 5.98 0.31 5.81e-9 Developmental language disorder (linguistic errors); CRC cis rs929354 0.713 rs1034785 chr7:157002383 T/C cg05182265 chr7:156933206 UBE3C -0.76 -14.45 -0.62 5.56e-37 Body mass index; CRC cis rs10540 1.000 rs12788729 chr11:502371 G/A cg08200582 chr11:442649 ANO9 -0.71 -7.44 -0.38 8.72e-13 Body mass index; CRC cis rs6499255 0.951 rs9788837 chr16:69688413 A/G cg04110750 chr16:69646130 NFAT5 -0.57 -7.85 -0.4 6.01e-14 IgE levels; CRC cis rs4713118 0.621 rs10484403 chr6:28033523 A/G cg12172441 chr6:28176163 NA 0.6 7.29 0.37 2.34e-12 Parkinson's disease; CRC cis rs2836974 0.965 rs2836965 chr21:40633631 C/G cg17971929 chr21:40555470 PSMG1 -0.8 -11.42 -0.53 1.15e-25 Cognitive function; CRC trans rs951252 0.504 rs11734405 chr4:146081096 C/T cg02005709 chr14:92492924 TRIP11 -0.53 -7.26 -0.37 2.81e-12 Hip circumference; CRC cis rs2952156 0.684 rs931992 chr17:37821435 G/T cg20243544 chr17:37824526 PNMT 0.55 8.74 0.43 1.17e-16 Asthma; CRC cis rs34034915 1 rs34034915 chr6:27720703 T/TG cg21251018 chr6:28226885 NKAPL 0.39 6.08 0.32 3.31e-9 Hepatitis A; CRC cis rs7258465 0.965 rs748609 chr19:18560282 T/C cg06462663 chr19:18546047 ISYNA1 0.49 7.27 0.37 2.64e-12 Breast cancer; CRC cis rs8031584 0.505 rs2959036 chr15:31219742 T/G cg08109568 chr15:31115862 NA 0.4 6.55 0.34 2.26e-10 Huntington's disease progression; CRC cis rs4604732 0.527 rs7546805 chr1:247627259 G/A cg12758973 chr1:247694275 LOC148824;OR2C3 0.42 6.1 0.32 2.98e-9 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CRC cis rs9457247 0.740 rs13195812 chr6:167443902 C/T cg07741184 chr6:167504864 NA 0.37 6.51 0.34 2.89e-10 Crohn's disease; CRC cis rs2985684 1.000 rs2147712 chr14:50091684 G/A cg10008539 chr14:50087325 RPL36AL;MGAT2 -0.45 -6.1 -0.32 3.01e-9 Carotid intima media thickness; CRC cis rs11690935 0.959 rs7586207 chr2:172671094 A/G cg13550731 chr2:172543902 DYNC1I2 -1.09 -18.52 -0.71 6.06e-53 Schizophrenia; CRC cis rs853679 0.517 rs3734573 chr6:28059437 T/C cg15845792 chr6:28175446 NA 0.98 13.03 0.58 1.45e-31 Depression; CRC cis rs6066835 1.000 rs6066830 chr20:47353897 C/T cg18078177 chr20:47281410 PREX1 0.63 5.75 0.3 2.01e-8 Multiple myeloma; CRC cis rs826838 1.000 rs11183469 chr12:38752311 G/A cg26384229 chr12:38710491 ALG10B 0.75 10.56 0.5 1.25e-22 Heart rate; CRC cis rs9814567 0.806 rs2293293 chr3:134322742 A/G cg06541857 chr3:134203789 ANAPC13;CEP63 -0.37 -5.75 -0.3 2e-8 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs4919694 1.000 rs75691516 chr10:104652045 C/T cg04362960 chr10:104952993 NT5C2 1.08 9.82 0.48 3.92e-20 Arsenic metabolism; CRC cis rs7809950 0.862 rs62482502 chr7:106987810 A/C cg23024343 chr7:107201750 COG5 -0.54 -7.57 -0.39 3.76e-13 Coronary artery disease; CRC cis rs1707322 0.717 rs3014246 chr1:46086077 C/T cg06784218 chr1:46089804 CCDC17 -0.66 -12.04 -0.55 6.3e-28 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs11628318 0.614 rs8010455 chr14:103164681 A/G cg23461800 chr14:103021989 NA 0.68 7.81 0.4 7.79e-14 Platelet count; CRC cis rs7811142 1.000 rs11763511 chr7:100081944 G/A cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.6 7.7 0.39 1.62e-13 Platelet count; CRC cis rs13191362 0.872 rs35443919 chr6:163055804 C/T cg23758597 chr6:163146217 PARK2 -0.68 -6.73 -0.35 7.44e-11 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs2576037 0.526 rs658756 chr18:44431832 A/G cg07643061 chr18:44555308 TCEB3C;TCEB3CL;KATNAL2 -0.32 -5.6 -0.3 4.51e-8 Personality dimensions; CRC cis rs66887589 0.934 rs4834792 chr4:120555696 T/A cg09307838 chr4:120376055 NA -0.51 -7.86 -0.4 5.42e-14 Diastolic blood pressure; CRC cis rs2836950 0.502 rs12627205 chr21:40630027 C/T cg17971929 chr21:40555470 PSMG1 -0.57 -8.21 -0.41 5.2e-15 Menarche (age at onset); CRC cis rs782590 0.902 rs2586947 chr2:55854009 C/G cg18811423 chr2:55921094 PNPT1 0.77 13.75 0.6 2.58e-34 Metabolic syndrome; CRC cis rs4147929 0.532 rs4147930 chr19:1064193 G/A cg26576206 chr19:1064938 ABCA7 0.4 5.73 0.3 2.22e-8 Alzheimer's disease (late onset); CRC cis rs3858526 0.959 rs11039723 chr11:5956002 G/C cg13902645 chr11:5959945 NA -0.67 -9.01 -0.44 1.73e-17 DNA methylation (variation); CRC cis rs2276314 1.000 rs9956938 chr18:33567061 A/G cg19628046 chr18:33552617 C18orf21 0.51 6.93 0.36 2.17e-11 Endometriosis;Drug-induced torsades de pointes; CRC cis rs12586317 0.553 rs3809448 chr14:35515096 C/T cg05294307 chr14:35346193 BAZ1A -0.71 -7.63 -0.39 2.51e-13 Psoriasis; CRC cis rs75422866 0.867 rs73102201 chr12:48063052 G/A cg14736327 chr12:48174669 SLC48A1 -0.79 -6.01 -0.31 4.92e-9 Pneumonia; CRC trans rs7395662 0.929 rs34584314 chr11:48627686 G/T cg21153622 chr11:89784906 NA -0.47 -7.5 -0.38 6.05e-13 HDL cholesterol; CRC cis rs7274811 0.901 rs1074683 chr20:32304653 C/G cg07470512 chr20:32255052 NECAB3;C20orf134 -0.5 -6.2 -0.32 1.65e-9 Height; CRC cis rs9291683 0.552 rs17187075 chr4:9990328 G/C cg00071950 chr4:10020882 SLC2A9 0.62 11.46 0.53 7.93e-26 Bone mineral density; CRC cis rs11764590 0.715 rs56289396 chr7:2091415 G/A cg02825527 chr7:2087843 MAD1L1 -0.48 -5.81 -0.3 1.5e-8 Neuroticism; CRC cis rs9814567 1.000 rs7619451 chr3:134233238 A/C cg06109529 chr3:134205091 CEP63;ANAPC13 -0.87 -12.12 -0.56 3.34e-28 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs1843834 0.539 rs2047135 chr2:225427302 G/C cg22455342 chr2:225449267 CUL3 0.67 9.07 0.45 1.14e-17 IgE levels in asthmatics (D.p. specific); CRC cis rs6951245 1.000 rs80212261 chr7:1114012 C/T cg22907277 chr7:1156413 C7orf50 0.76 8.07 0.41 1.31e-14 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs8014204 0.762 rs12891131 chr14:75240090 A/G cg03030879 chr14:75389066 RPS6KL1 -0.41 -6.47 -0.34 3.62e-10 Caffeine consumption; CRC cis rs8049040 0.547 rs12934168 chr16:71436778 C/T cg08717414 chr16:71523259 ZNF19 -0.41 -5.61 -0.3 4.4e-8 Blood protein levels; CRC trans rs2228479 0.867 rs11645970 chr16:89958118 G/A cg24644049 chr4:85504048 CDS1 0.84 7.48 0.38 6.98e-13 Skin colour saturation; CRC cis rs60871478 0.636 rs4719520 chr7:875216 C/G cg05535760 chr7:792225 HEATR2 -0.9 -10.21 -0.49 1.89e-21 Cerebrospinal P-tau181p levels; CRC cis rs919433 0.783 rs805497 chr2:198222548 A/T cg20885578 chr2:198174922 NA 0.36 5.77 0.3 1.85e-8 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC cis rs8005677 1.000 rs8014936 chr14:23375145 A/G cg25600027 chr14:23388339 RBM23 -0.53 -8.37 -0.42 1.63e-15 Cognitive ability (multi-trait analysis); CRC cis rs3764563 0.660 rs8107923 chr19:15737899 A/T cg20725493 chr19:15740067 CYP4F8 -0.75 -7.61 -0.39 2.89e-13 Inflammatory biomarkers; CRC cis rs2440129 0.611 rs1126667 chr17:6902760 C/T cg05657792 chr17:6899758 ALOX12 -0.45 -8.18 -0.41 6.45e-15 Tonsillectomy; CRC cis rs6502050 0.787 rs11653012 chr17:80058857 C/T cg19223190 chr17:80058835 NA -0.44 -7.16 -0.37 5.41e-12 Life satisfaction; CRC cis rs4728302 0.869 rs10255193 chr7:133608911 C/G cg10665199 chr7:133106180 EXOC4 0.39 5.8 0.3 1.56e-8 Intelligence;Intelligence (multi-trait analysis); CRC cis rs597539 0.652 rs544370 chr11:68653232 C/T cg06028808 chr11:68637592 NA 0.4 6.51 0.34 2.87e-10 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs3736485 0.578 rs2305716 chr15:51981291 C/T cg08986416 chr15:51914746 DMXL2 -0.4 -5.86 -0.31 1.14e-8 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs2281845 0.826 rs4915484 chr1:201076917 C/G cg17810781 chr1:201082982 CACNA1S 0.4 6.73 0.35 7.7e-11 Permanent tooth development; CRC cis rs11252926 0.550 rs10795122 chr10:466830 C/T cg18196295 chr10:418757 DIP2C 0.54 8.05 0.41 1.52e-14 Psychosis in Alzheimer's disease; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg10070151 chr19:39881965 MED29;PAF1 0.44 6.46 0.34 3.78e-10 Intelligence (multi-trait analysis); CRC cis rs769267 0.930 rs1054284 chr19:19616953 T/G cg02546618 chr19:19431379 KIAA0892;SF4 0.43 5.86 0.31 1.1e-8 Tonsillectomy; CRC cis rs853679 0.517 rs2275508 chr6:28094731 T/C cg02683197 chr6:28174875 NA 0.85 10.69 0.51 4.25e-23 Depression; CRC trans rs10021731 0.718 rs2199310 chr4:115413402 G/A cg25927708 chr2:119603813 EN1 -0.33 -6.02 -0.31 4.78e-9 Optic disc area; CRC trans rs7267979 1.000 rs4813566 chr20:25386465 G/T cg17903999 chr18:56338584 MALT1 0.42 6.93 0.36 2.17e-11 Liver enzyme levels (alkaline phosphatase); CRC cis rs12586317 0.547 rs13379372 chr14:35483882 A/C cg05294307 chr14:35346193 BAZ1A -0.7 -7.7 -0.39 1.65e-13 Psoriasis; CRC trans rs7615952 0.546 rs2979338 chr3:125343126 G/T cg21747405 chr11:67723411 NA -0.49 -6.32 -0.33 8.59e-10 Blood pressure (smoking interaction); CRC cis rs6502050 0.835 rs6502069 chr17:80112599 G/T cg02741985 chr17:80059408 CCDC57 0.43 7.15 0.37 5.66e-12 Life satisfaction; CRC cis rs847577 0.748 rs55784506 chr7:97718201 G/A cg21770322 chr7:97807741 LMTK2 0.84 18.44 0.71 1.21e-52 Breast cancer; CRC cis rs838147 0.507 rs692854 chr19:49209464 C/A cg21064579 chr19:49206444 FUT2 0.47 8.18 0.41 6.16e-15 Dietary macronutrient intake; CRC cis rs514406 0.668 rs520281 chr1:53365235 G/C cg24675658 chr1:53192096 ZYG11B -0.69 -10.13 -0.49 3.47e-21 Monocyte count; CRC cis rs12580194 0.593 rs12581959 chr12:55787311 G/A cg19537932 chr12:55886519 OR6C68 -0.74 -8.88 -0.44 4.44e-17 Cancer; CRC cis rs755249 0.567 rs112672438 chr1:39646787 C/T cg18385671 chr1:39797026 MACF1 -0.41 -5.93 -0.31 7.46e-9 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs950027 0.620 rs1153860 chr15:45636584 A/G cg21132104 chr15:45694354 SPATA5L1 -0.44 -6.61 -0.34 1.56e-10 Response to fenofibrate (adiponectin levels); CRC cis rs7213347 0.707 rs216215 chr17:2140668 C/T cg24045832 chr17:1955481 NA 0.36 5.66 0.3 3.37e-8 Total body bone mineral density; CRC cis rs7591163 1.000 rs940341 chr2:228724726 A/G cg22079747 chr2:228736145 WDR69 -0.42 -5.72 -0.3 2.37e-8 Blood pressure; CRC cis rs7618501 0.633 rs2526748 chr3:50080439 A/G cg24308560 chr3:49941425 MST1R 0.53 8.92 0.44 3.38e-17 Intelligence (multi-trait analysis); CRC cis rs10861342 1.000 rs7305712 chr12:105519188 A/T cg23923672 chr12:105501055 KIAA1033 -0.6 -5.73 -0.3 2.28e-8 IgG glycosylation; CRC cis rs7493 0.760 rs17876092 chr7:95053313 C/A cg01874867 chr7:94954059 PON1 -0.54 -6.57 -0.34 1.99e-10 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs2108622 0.727 rs62106155 chr19:15980360 G/C cg13772218 chr19:15982569 NA 0.48 6.82 0.35 4.37e-11 Circulating phylloquinone levels;Vitamin E levels;Acenocoumarol maintenance dosage;Response to Vitamin E supplementation;Metabolite levels;Warfarin maintenance dose; CRC cis rs7107174 1.000 rs2511157 chr11:77972632 G/A cg02023728 chr11:77925099 USP35 0.53 7.54 0.38 4.74e-13 Testicular germ cell tumor; CRC cis rs2011503 0.941 rs11555053 chr19:19390185 G/A cg11584989 chr19:19387371 SF4 0.55 6.58 0.34 1.82e-10 Bipolar disorder; CRC cis rs1707322 0.721 rs12043945 chr1:46106922 T/A cg03146154 chr1:46216737 IPP 0.67 9.85 0.48 3.2e-20 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs11583043 0.872 rs1326380 chr1:101293753 G/T cg16556008 chr1:101360663 SLC30A7;EXTL2 0.49 6.6 0.34 1.62e-10 Ulcerative colitis;Inflammatory bowel disease; CRC trans rs12714668 0.502 rs6549114 chr3:86819661 C/T cg13618939 chr10:46090486 MARCH8 -0.47 -6.06 -0.32 3.62e-9 Plasma omega-6 polyunsaturated fatty acid levels (arachidonic acid); CRC cis rs7772486 0.754 rs697053 chr6:145989807 T/C cg13319975 chr6:146136371 FBXO30 0.47 6.88 0.35 3.05e-11 Lobe attachment (rater-scored or self-reported); CRC cis rs2859741 0.565 rs11263962 chr1:37509239 C/T cg09363841 chr1:37513479 NA -0.47 -7.26 -0.37 2.72e-12 Forced expiratory volume in 1 second (environmental tobacco smoke interaction); CRC trans rs1814175 0.509 rs60698301 chr11:49877672 G/A cg11707556 chr5:10655725 ANKRD33B -0.51 -9.67 -0.47 1.25e-19 Height; CRC cis rs3858526 0.920 rs11511938 chr11:5928793 A/G cg05234568 chr11:5960015 NA -0.56 -7.76 -0.39 1.1e-13 DNA methylation (variation); CRC cis rs7647973 0.580 rs11716334 chr3:49230096 G/A cg03060546 chr3:49711283 APEH 0.47 7.0 0.36 1.48e-11 Menarche (age at onset); CRC cis rs7044106 0.791 rs2416797 chr9:123480600 C/A cg14255062 chr9:123606675 PSMD5;LOC253039 0.46 6.72 0.35 8.06e-11 Hip circumference adjusted for BMI; CRC cis rs4665809 0.549 rs3828255 chr2:26413252 G/A cg25036284 chr2:26402008 FAM59B 0.69 8.16 0.41 7.03e-15 Gut microbiome composition (summer); CRC cis rs7107174 1.000 rs4128206 chr11:78015952 A/C cg02023728 chr11:77925099 USP35 0.47 8.04 0.41 1.64e-14 Testicular germ cell tumor; CRC cis rs73200209 0.833 rs2161859 chr12:116455513 A/T cg01776926 chr12:116560359 MED13L -0.47 -5.9 -0.31 9.12e-9 Total body bone mineral density; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg22715954 chr12:58146426 CDK4 0.43 6.05 0.32 3.91e-9 Response to antipsychotic treatment; CRC cis rs28374715 0.635 rs28557159 chr15:41657353 T/C cg18705301 chr15:41695430 NDUFAF1 -0.87 -14.42 -0.62 7.2e-37 Ulcerative colitis; CRC trans rs116095464 0.558 rs9687621 chr5:229194 C/T cg00938859 chr5:1591904 SDHAP3 0.67 6.13 0.32 2.45e-9 Breast cancer; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg12223105 chr20:4153034 SMOX 0.41 6.42 0.33 4.75e-10 Intelligence (multi-trait analysis); CRC cis rs2839186 0.560 rs9975345 chr21:47843004 T/C cg11766577 chr21:47581405 C21orf56 0.35 5.73 0.3 2.26e-8 Testicular germ cell tumor; CRC cis rs1801251 0.928 rs737028 chr2:233640750 T/C cg25237894 chr2:233734115 C2orf82 0.54 8.85 0.44 5.52e-17 Coronary artery disease; CRC cis rs7959452 0.562 rs11177630 chr12:69767963 G/C cg22834771 chr12:69754056 YEATS4 -0.54 -8.1 -0.41 1.07e-14 Blood protein levels; CRC cis rs4555082 0.834 rs2735817 chr14:105717796 A/G cg06808227 chr14:105710500 BRF1 0.61 9.12 0.45 7.84e-18 Mean platelet volume;Platelet distribution width; CRC trans rs10207628 1.000 rs76168490 chr2:127850618 C/G cg22628694 chr19:58663362 ZNF329 0.57 6.08 0.32 3.36e-9 Psychosis and Alzheimer's disease; CRC cis rs1267303 0.642 rs6696219 chr1:47000408 T/C cg25110126 chr1:46999211 NA 0.59 8.97 0.44 2.24e-17 Monobrow; CRC cis rs7615952 0.599 rs6803160 chr3:125709554 G/T cg04553112 chr3:125709451 NA -0.49 -5.69 -0.3 2.84e-8 Blood pressure (smoking interaction); CRC cis rs8062405 0.964 rs9972768 chr16:28861734 A/C cg08761264 chr16:28874980 SH2B1 -0.44 -5.84 -0.31 1.27e-8 Cognitive ability (multi-trait analysis);Cognitive ability; CRC cis rs6951245 0.935 rs61910751 chr7:1097895 A/G cg21664854 chr7:1097933 C7orf50;GPR146 0.77 8.8 0.44 7.85e-17 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs6582630 0.500 rs35251810 chr12:38577666 T/C cg13010199 chr12:38710504 ALG10B -0.43 -6.12 -0.32 2.63e-9 Drug-induced liver injury (flucloxacillin); CRC cis rs9894429 0.690 rs12949956 chr17:79542813 C/T cg21984481 chr17:79567631 NPLOC4 0.58 10.83 0.51 1.45e-23 Eye color traits; CRC cis rs1552244 0.938 rs7652951 chr3:10063763 A/C cg10729496 chr3:10149963 C3orf24 0.5 6.71 0.35 8.29e-11 Alzheimer's disease; CRC cis rs3785574 0.962 rs2584633 chr17:61879501 T/C cg06601766 chr17:61851465 DDX42;CCDC47 0.61 8.68 0.43 1.83e-16 Height; CRC cis rs1799949 1.000 rs11653253 chr17:41182662 G/A cg05368731 chr17:41323189 NBR1 0.69 10.07 0.49 5.76e-21 Menopause (age at onset); CRC cis rs68170813 0.641 rs12534124 chr7:107119047 G/A cg02696742 chr7:106810147 HBP1 -0.53 -5.61 -0.3 4.23e-8 Coronary artery disease; CRC cis rs6968419 0.755 rs17138486 chr7:115894403 C/G cg02561103 chr7:115862891 TES -0.43 -6.47 -0.34 3.48e-10 Intraocular pressure; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg11556929 chr2:240323605 HDAC4 0.45 6.28 0.33 1.06e-9 Anxiety disorder; CRC cis rs1577917 1.000 rs35761942 chr6:86629504 C/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.58 -7.17 -0.37 5.12e-12 Response to antipsychotic treatment; CRC trans rs925098 0.577 rs2724470 chr4:17996046 A/G cg22385477 chr4:186392754 CCDC110 -0.42 -6.33 -0.33 8.12e-10 Birth weight;Height; CRC cis rs7737355 0.812 rs10054168 chr5:130788698 C/T cg06307176 chr5:131281290 NA -0.37 -5.78 -0.3 1.74e-8 Life satisfaction; CRC cis rs4555082 0.874 rs2015978 chr14:105720134 G/C cg18132624 chr14:105716052 BTBD6;BRF1 -0.48 -7.73 -0.39 1.36e-13 Mean platelet volume;Platelet distribution width; CRC cis rs3806843 0.966 rs2563255 chr5:140142547 T/C cg19875535 chr5:140030758 IK -0.55 -8.8 -0.44 7.81e-17 Depressive symptoms (multi-trait analysis); CRC trans rs1814175 0.817 rs28679516 chr11:50055998 G/A cg11707556 chr5:10655725 ANKRD33B -0.42 -8.03 -0.4 1.75e-14 Height; CRC cis rs11098499 0.780 rs10013652 chr4:120292256 A/G cg09307838 chr4:120376055 NA 0.68 10.49 0.5 2.15e-22 Corneal astigmatism; CRC cis rs9325144 0.555 rs4882359 chr12:38726679 T/C cg26384229 chr12:38710491 ALG10B 0.53 7.95 0.4 3.02e-14 Morning vs. evening chronotype; CRC cis rs4713118 0.662 rs149901 chr6:27965503 C/T cg12273811 chr6:28175739 NA 0.6 8.82 0.44 7e-17 Parkinson's disease; CRC cis rs7208859 0.623 rs9912440 chr17:29148772 A/G cg01831904 chr17:28903510 LRRC37B2 -0.61 -6.14 -0.32 2.43e-9 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs12701220 0.895 rs12534778 chr7:1065861 C/T cg06145435 chr7:1022769 CYP2W1 -0.41 -5.85 -0.31 1.22e-8 Bronchopulmonary dysplasia; CRC trans rs6546324 0.625 rs6746394 chr2:67845021 A/C cg00907274 chr3:27498161 SLC4A7 -0.49 -6.21 -0.32 1.6e-9 Endometriosis; CRC cis rs9916302 0.904 rs1077715 chr17:37683548 A/T cg07936489 chr17:37558343 FBXL20 -0.78 -11.7 -0.54 1.16e-26 Glomerular filtration rate (creatinine); CRC cis rs734999 0.588 rs2985859 chr1:2532416 T/C cg20673091 chr1:2541236 MMEL1 -0.36 -5.79 -0.3 1.67e-8 Ulcerative colitis; CRC cis rs7827545 1.000 rs6995244 chr8:135568959 A/G cg13086574 chr8:135490821 ZFAT -0.37 -6.36 -0.33 6.63e-10 Hypertension (SNP x SNP interaction); CRC cis rs7811142 1.000 rs67471932 chr7:100009985 C/G cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.97 13.45 0.6 3.81e-33 Platelet count; CRC trans rs2727020 0.729 rs10742932 chr11:49173234 T/C cg11707556 chr5:10655725 ANKRD33B -0.39 -7.21 -0.37 3.92e-12 Coronary artery disease; CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg17675882 chr20:35374068 NDRG3 -0.55 -6.78 -0.35 5.71e-11 Diisocyanate-induced asthma; CRC cis rs1707322 1.000 rs4660896 chr1:46372416 A/G cg03146154 chr1:46216737 IPP 0.51 7.16 0.37 5.32e-12 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg23200371 chr12:56367680 RAB5B -0.4 -6.14 -0.32 2.33e-9 Myopia (pathological); CRC cis rs7647973 1.000 rs62259947 chr3:49439924 T/C cg07690219 chr3:49449608 TCTA;RHOA 0.52 5.71 0.3 2.5e-8 Menarche (age at onset); CRC trans rs4650994 0.935 rs4652306 chr1:178528206 T/C cg05059571 chr16:84539110 KIAA1609 -0.45 -6.82 -0.35 4.36e-11 HDL cholesterol levels;HDL cholesterol; CRC cis rs9443645 0.527 rs10943595 chr6:79575291 C/G cg05283184 chr6:79620031 NA -0.45 -6.57 -0.34 2e-10 Intelligence (multi-trait analysis); CRC cis rs9487051 0.768 rs12176068 chr6:109521629 C/T cg01475377 chr6:109611718 NA -0.33 -5.79 -0.3 1.62e-8 Reticulocyte fraction of red cells; CRC cis rs17209837 1.000 rs2302385 chr7:87091826 T/C cg00919237 chr7:87102261 ABCB4 -0.47 -5.63 -0.3 3.84e-8 Gallbladder cancer; CRC cis rs7193541 0.585 rs7978 chr16:74486189 T/C cg01733217 chr16:74700730 RFWD3 -0.87 -16.95 -0.68 9.45e-47 Multiple myeloma; CRC cis rs7618915 0.501 rs34157897 chr3:52716937 T/C cg05573699 chr3:52720067 GNL3;PBRM1 -0.49 -7.24 -0.37 3.14e-12 Bipolar disorder; CRC cis rs9527 0.590 rs2274339 chr10:104860053 T/A cg15744005 chr10:104629667 AS3MT -0.3 -5.97 -0.31 6.19e-9 Arsenic metabolism; CRC cis rs9916302 0.851 rs7225096 chr17:37664443 T/C cg03013999 chr17:37608204 MED1 0.45 6.92 0.36 2.36e-11 Glomerular filtration rate (creatinine); CRC cis rs798554 0.797 rs798493 chr7:2798731 A/G cg04166393 chr7:2884313 GNA12 0.5 6.65 0.34 1.24e-10 Height; CRC cis rs11264799 0.598 rs12567349 chr1:157731186 G/A cg11810135 chr1:157771971 FCRL1 0.39 6.01 0.31 4.95e-9 IgA nephropathy; CRC cis rs651907 0.557 rs3806653 chr3:101396972 T/C cg12386194 chr3:101231763 SENP7 0.49 7.11 0.36 7.34e-12 Colorectal cancer; CRC cis rs6580649 0.941 rs1793933 chr12:48396450 G/T cg05342945 chr12:48394962 COL2A1 -0.46 -6.36 -0.33 6.58e-10 Lung cancer; CRC cis rs35146811 0.771 rs1060544 chr7:99613476 C/T cg13334819 chr7:99746414 C7orf59 -0.58 -7.83 -0.4 6.6e-14 Coronary artery disease; CRC cis rs9308731 0.623 rs2241842 chr2:111879415 A/G cg04202892 chr2:111875749 ACOXL 0.43 6.94 0.36 2.09e-11 Chronic lymphocytic leukemia; CRC cis rs780096 0.506 rs56076827 chr2:27676287 A/T cg12648201 chr2:27665141 KRTCAP3 -0.32 -6.09 -0.32 3.23e-9 Total body bone mineral density; CRC cis rs11190604 1.000 rs11190589 chr10:102275471 A/G cg16342193 chr10:102329863 NA -0.34 -5.73 -0.3 2.29e-8 Palmitoleic acid (16:1n-7) levels; CRC cis rs7666738 0.830 rs6532724 chr4:99060993 C/T cg05340658 chr4:99064831 C4orf37 0.61 9.47 0.46 5.5e-19 Colonoscopy-negative controls vs population controls; CRC trans rs9914544 0.689 rs8073236 chr17:18787182 C/G cg21372672 chr17:16614065 CCDC144A -0.39 -6.15 -0.32 2.23e-9 Educational attainment (years of education); CRC cis rs9916302 0.706 rs9908131 chr17:37520449 T/C cg15445000 chr17:37608096 MED1 -0.35 -6.22 -0.32 1.48e-9 Glomerular filtration rate (creatinine); CRC cis rs28735056 0.875 rs62103176 chr18:77623611 G/C cg12845895 chr18:77676008 PQLC1 0.43 6.17 0.32 2.04e-9 Schizophrenia; CRC cis rs4750440 0.585 rs10508470 chr10:14021822 G/A cg00551146 chr10:14014579 FRMD4A 0.47 7.47 0.38 7.45e-13 Adiponectin levels; CRC cis rs7258465 1.000 rs2303697 chr19:18546678 T/C cg06462663 chr19:18546047 ISYNA1 0.5 7.4 0.38 1.16e-12 Breast cancer; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg14035508 chr11:124543525 SIAE;SPA17 0.42 6.17 0.32 2.03e-9 Intelligence (multi-trait analysis); CRC cis rs2153535 0.580 rs2184585 chr6:8474168 G/A cg07606381 chr6:8435919 SLC35B3 0.68 10.9 0.51 8.26e-24 Motion sickness; CRC cis rs9467711 0.720 rs35627490 chr6:26462104 C/T cg12315302 chr6:26189340 HIST1H4D 0.96 6.61 0.34 1.58e-10 Autism spectrum disorder or schizophrenia; CRC cis rs2243480 1.000 rs67728539 chr7:65378124 G/A cg12463550 chr7:65579703 CRCP 0.65 6.15 0.32 2.19e-9 Diabetic kidney disease; CRC cis rs6502050 0.835 rs7503225 chr17:80099639 C/A cg25804541 chr17:80189381 SLC16A3 -0.31 -5.97 -0.31 6.08e-9 Life satisfaction; CRC cis rs875971 0.660 rs10215132 chr7:66054406 C/A cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.43 -6.33 -0.33 8.25e-10 Aortic root size; CRC cis rs6951245 0.572 rs75083636 chr7:1050800 C/T cg20603222 chr7:1096387 C7orf50;GPR146 -0.69 -5.7 -0.3 2.69e-8 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs2370759 1.000 rs76467481 chr10:32610740 T/G cg01819863 chr10:32635814 EPC1 1.08 12.64 0.57 3.89e-30 Sexual dysfunction (female); CRC cis rs2249694 1.000 rs2480258 chr10:135352100 T/C cg16964102 chr10:135390573 NA -0.38 -6.21 -0.32 1.57e-9 Obesity-related traits; CRC cis rs1215050 0.704 rs783915 chr4:99023151 C/G cg05340658 chr4:99064831 C4orf37 0.48 7.36 0.38 1.53e-12 Waist-to-hip ratio adjusted for body mass index; CRC cis rs2836974 0.526 rs418359 chr21:40536734 T/C cg22974920 chr21:40686053 BRWD1 -0.43 -6.11 -0.32 2.84e-9 Cognitive function; CRC cis rs769267 1.000 rs2301669 chr19:19453560 C/A cg20644253 chr19:19431407 KIAA0892;SF4 -0.41 -5.74 -0.3 2.13e-8 Tonsillectomy; CRC cis rs875971 0.619 rs12533585 chr7:65984605 G/C cg00343986 chr7:65444356 GUSB 0.49 7.42 0.38 1e-12 Aortic root size; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg00986762 chr1:36107072 PSMB2 0.48 6.21 0.32 1.56e-9 Thyroid stimulating hormone; CRC cis rs7715806 0.500 rs17563974 chr5:75004175 G/A cg19683494 chr5:74908142 NA 0.51 5.71 0.3 2.51e-8 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs28386778 0.830 rs2597636 chr17:61876010 A/G cg22520471 chr17:61851767 DDX42;CCDC47 0.75 11.65 0.54 1.65e-26 Prudent dietary pattern; CRC cis rs2281845 0.791 rs1325313 chr1:201076167 C/T cg17810781 chr1:201082982 CACNA1S 0.41 6.79 0.35 5.16e-11 Permanent tooth development; CRC cis rs35110281 0.715 rs2838320 chr21:44995037 A/G cg01579765 chr21:45077557 HSF2BP -0.37 -7.1 -0.36 7.67e-12 Mean corpuscular volume; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg22478328 chr22:32340140 C22orf24;YWHAH 0.56 7.38 0.38 1.3e-12 Thyroid stimulating hormone; CRC trans rs2243480 1.000 rs4718270 chr7:65202407 A/G cg10756647 chr7:56101905 PSPH 0.71 7.54 0.38 4.76e-13 Diabetic kidney disease; CRC cis rs7487075 0.856 rs1079780 chr12:46736023 C/T cg22049899 chr12:47219821 SLC38A4 0.33 6.15 0.32 2.23e-9 Itch intensity from mosquito bite; CRC cis rs11764590 0.715 rs62444907 chr7:2083267 C/T cg21155852 chr7:2048760 MAD1L1 -0.47 -6.16 -0.32 2.14e-9 Neuroticism; CRC cis rs2243480 0.803 rs35268390 chr7:65416536 C/G cg12463550 chr7:65579703 CRCP 0.63 5.98 0.31 5.8e-9 Diabetic kidney disease; CRC cis rs66573146 1.000 rs28384174 chr4:6961107 G/T cg26116260 chr4:7069785 GRPEL1 -0.8 -6.51 -0.34 2.86e-10 Granulocyte percentage of myeloid white cells; CRC cis rs10883723 0.775 rs7917158 chr10:104246471 C/A cg04362960 chr10:104952993 NT5C2 -0.43 -6.03 -0.32 4.4e-9 Allergic disease (asthma, hay fever or eczema); CRC trans rs853679 1.000 rs1679709 chr6:28228342 A/G cg06606381 chr12:133084897 FBRSL1 0.6 6.01 0.31 4.93e-9 Depression; CRC cis rs9858542 0.953 rs35115732 chr3:49475155 T/C cg03060546 chr3:49711283 APEH -0.46 -6.49 -0.34 3.17e-10 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs13108904 0.870 rs4974578 chr4:1266072 A/G cg21620606 chr4:1342894 KIAA1530 0.38 6.4 0.33 5.46e-10 Obesity-related traits; CRC cis rs3858526 0.523 rs10769289 chr11:5886607 C/T cg26762873 chr11:5879799 OR52E8 -0.48 -7.48 -0.38 6.84e-13 DNA methylation (variation); CRC cis rs2019137 0.560 rs11123172 chr2:113984303 C/T cg11763394 chr2:113992921 PAX8;LOC440839;LOC654433 -0.64 -10.07 -0.49 5.74e-21 Lymphocyte counts; CRC cis rs7927592 0.513 rs608343 chr11:68196830 T/C cg01657329 chr11:68192670 LRP5 -0.61 -9.74 -0.47 7.11e-20 Total body bone mineral density; CRC cis rs863345 0.604 rs7518708 chr1:158504274 C/T cg12129480 chr1:158549410 OR10X1 -0.3 -6.27 -0.33 1.12e-9 Pneumococcal bacteremia; CRC cis rs4713118 0.568 rs9468213 chr6:27706180 G/A cg15786705 chr6:28176104 NA 0.49 6.99 0.36 1.5e-11 Parkinson's disease; CRC cis rs12348691 0.503 rs10739513 chr9:100592705 C/T cg13688889 chr9:100608707 NA -0.48 -6.18 -0.32 1.85e-9 Alopecia areata; CRC cis rs734999 0.549 rs3828154 chr1:2524943 G/A cg20673091 chr1:2541236 MMEL1 0.36 5.82 0.31 1.43e-8 Ulcerative colitis; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg04787407 chr4:99916511 METAP1 0.53 7.58 0.39 3.66e-13 Response to antipsychotic treatment; CRC cis rs1448094 0.967 rs10863109 chr12:86328415 A/G cg19622623 chr12:86230825 RASSF9 -0.35 -5.69 -0.3 2.8e-8 Major depressive disorder; CRC trans rs561341 1.000 rs1681718 chr17:30296445 G/A cg27661571 chr11:113659931 NA -0.95 -11.08 -0.52 1.91e-24 Hip circumference adjusted for BMI; CRC cis rs4853036 0.597 rs1048165 chr2:70131964 A/C cg02498382 chr2:70120550 SNRNP27 -0.42 -5.96 -0.31 6.66e-9 Colorectal or endometrial cancer; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg10891888 chr12:46765615 SLC38A2 0.44 6.24 0.33 1.34e-9 Response to antipsychotic treatment; CRC cis rs72615157 0.634 rs74774557 chr7:99810425 A/G cg13153964 chr7:100026424 MEPCE;ZCWPW1 0.84 10.23 0.49 1.71e-21 Lung function (FEV1/FVC); CRC cis rs1950626 0.750 rs34144313 chr14:101431216 C/G cg02351406 chr14:101447389 SNORD114-20;SNORD114-21 0.95 15.47 0.65 6.02e-41 Pelvic organ prolapse (moderate/severe); CRC cis rs2749592 0.505 rs7915670 chr10:37870212 T/C cg25517755 chr10:38738941 LOC399744 0.42 5.98 0.31 5.86e-9 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs9914988 0.887 rs11656272 chr17:27091153 A/G cg12682573 chr17:27188876 MIR451;MIR144 0.58 7.98 0.4 2.43e-14 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC trans rs11098499 0.908 rs11729050 chr4:120300066 T/C cg25214090 chr10:38739885 LOC399744 0.62 9.74 0.47 7.35e-20 Corneal astigmatism; CRC cis rs9611565 0.500 rs10775759 chr22:42088158 T/C cg03806693 chr22:41940476 POLR3H 0.96 12.52 0.57 1.15e-29 Vitiligo; CRC cis rs1950626 0.743 rs12884454 chr14:101465627 G/A cg02351406 chr14:101447389 SNORD114-20;SNORD114-21 0.98 15.63 0.65 1.37e-41 Pelvic organ prolapse (moderate/severe); CRC cis rs1348850 0.632 rs10167783 chr2:178519041 G/A cg22681709 chr2:178499509 PDE11A -0.5 -9.18 -0.45 4.75e-18 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs2949837 0.581 rs2965074 chr7:45983129 G/T cg23193639 chr7:45961078 IGFBP3 0.4 6.69 0.35 9.88e-11 Sitting height ratio; CRC cis rs798554 0.796 rs2158694 chr7:2863443 T/G cg17321639 chr7:2759063 NA -0.53 -7.11 -0.37 7.11e-12 Height; CRC trans rs6703335 0.870 rs10803142 chr1:243598234 A/G cg20540378 chr5:149340137 SLC26A2 0.44 6.11 0.32 2.88e-9 Schizophrenia;Schizophrenia, schizoaffective disorder or bipolar disorder; CRC cis rs4665809 1.000 rs4665811 chr2:26260017 A/G cg26119090 chr2:26468346 HADHA;HADHB -0.62 -7.92 -0.4 3.71e-14 Gut microbiome composition (summer); CRC cis rs1707322 0.716 rs6694889 chr1:46101806 A/C cg03146154 chr1:46216737 IPP 0.67 9.75 0.47 6.55e-20 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs13108904 0.934 rs13124383 chr4:1299986 C/T cg02018176 chr4:1364513 KIAA1530 0.46 7.46 0.38 7.77e-13 Obesity-related traits; CRC cis rs13108904 0.535 rs1250101 chr4:1236111 G/A cg20887711 chr4:1340912 KIAA1530 -0.68 -9.26 -0.45 2.66e-18 Obesity-related traits; CRC cis rs311392 0.525 rs366276 chr8:55100181 T/C cg06042504 chr8:55087323 NA -0.37 -5.78 -0.3 1.71e-8 Pelvic organ prolapse (moderate/severe); CRC cis rs4862750 0.872 rs6811569 chr4:187897988 A/G cg22105103 chr4:187893119 NA -0.62 -10.94 -0.52 5.68e-24 Lobe attachment (rater-scored or self-reported); CRC cis rs7264396 0.709 rs2425073 chr20:34293699 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.63 -10.56 -0.5 1.18e-22 Total cholesterol levels; CRC cis rs7932354 0.583 rs3136447 chr11:46744368 T/C cg19486271 chr11:47235900 DDB2 0.45 5.84 0.31 1.25e-8 Bone mineral density (hip);Bone mineral density; CRC cis rs7044106 0.762 rs1530370 chr9:123424552 C/T cg09419670 chr9:123605666 PSMD5;LOC253039 0.69 10.61 0.5 8.45e-23 Hip circumference adjusted for BMI; CRC cis rs936229 0.690 rs2472300 chr15:75033909 A/G cg14664628 chr15:75095509 CSK -0.87 -14.54 -0.63 2.49e-37 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); CRC cis rs17826219 0.568 rs9903854 chr17:29153998 C/T cg01831904 chr17:28903510 LRRC37B2 -0.62 -6.5 -0.34 2.9e-10 Body mass index; CRC trans rs11039798 0.512 rs1588069 chr11:48694871 A/G cg03929089 chr4:120376271 NA 0.67 6.98 0.36 1.65e-11 Axial length; CRC cis rs6952808 0.929 rs12667688 chr7:1931030 C/T cg00106254 chr7:1943704 MAD1L1 -0.51 -7.43 -0.38 9.22e-13 Bipolar disorder and schizophrenia; CRC cis rs9443189 0.813 rs2647410 chr6:76433825 A/G cg01950844 chr6:76311363 SENP6 -0.59 -7.6 -0.39 3.13e-13 Prostate cancer; CRC cis rs9311474 0.659 rs7638808 chr3:52572056 C/T cg15147215 chr3:52552868 STAB1 0.68 12.53 0.57 1.05e-29 Electroencephalogram traits; CRC cis rs10256972 0.713 rs10435026 chr7:1065948 A/G cg22907277 chr7:1156413 C7orf50 0.47 6.7 0.35 9.13e-11 Longevity;Endometriosis; CRC cis rs11945232 1.000 rs28372775 chr4:88343704 G/A cg23841344 chr4:88312519 HSD17B11 -0.51 -6.58 -0.34 1.9e-10 Intelligence (multi-trait analysis); CRC cis rs1443512 0.812 rs2078098 chr12:54337527 C/A cg17410650 chr12:54324560 NA -0.33 -6.05 -0.32 3.97e-9 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for BMI in non-smokers;Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction);Waist-hip ratio;Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour); CRC cis rs55692411 0.517 rs62262106 chr3:49991427 A/G cg05623727 chr3:50126028 RBM5 0.53 6.97 0.36 1.71e-11 Intelligence (multi-trait analysis); CRC cis rs9292777 0.720 rs55937028 chr5:40412509 G/A cg09067459 chr5:40385259 NA -0.54 -8.68 -0.43 1.93e-16 Crohn's disease;Multiple sclerosis; CRC cis rs13161895 1.000 rs35135297 chr5:179469532 T/C cg02702477 chr5:179499311 RNF130 0.55 6.26 0.33 1.18e-9 LDL cholesterol; CRC cis rs4474465 0.850 rs10899549 chr11:78255389 T/C cg02023728 chr11:77925099 USP35 -0.35 -5.99 -0.31 5.35e-9 Alzheimer's disease (survival time); CRC trans rs7618501 0.633 rs2526751 chr3:50064867 T/C cg21659725 chr3:3221576 CRBN -0.61 -9.59 -0.47 2.32e-19 Intelligence (multi-trait analysis); CRC cis rs9858542 0.953 rs6446272 chr3:49463287 G/A cg00383909 chr3:49044727 WDR6 0.44 5.69 0.3 2.8e-8 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs9894429 0.646 rs9905639 chr17:79614154 A/G cg21984481 chr17:79567631 NPLOC4 -0.41 -7.19 -0.37 4.5e-12 Eye color traits; CRC cis rs4909189 1.000 rs4909189 chr7:158136986 A/T cg25566285 chr7:158114605 PTPRN2 -0.44 -6.45 -0.33 4.09e-10 Response to amphetamines; CRC cis rs7618915 0.571 rs6762457 chr3:52609157 G/A cg07507251 chr3:52567010 NT5DC2 0.43 6.2 0.32 1.68e-9 Bipolar disorder; CRC cis rs6570726 0.837 rs636894 chr6:145864122 T/C cg23711669 chr6:146136114 FBXO30 0.71 12.36 0.56 4.44e-29 Lobe attachment (rater-scored or self-reported); CRC cis rs1448094 0.512 rs7302741 chr12:86237127 C/T cg18827107 chr12:86230957 RASSF9 -0.49 -8.07 -0.41 1.3e-14 Major depressive disorder; CRC cis rs7666738 1.000 rs13144055 chr4:99026849 A/G cg05340658 chr4:99064831 C4orf37 0.52 7.32 0.37 1.86e-12 Colonoscopy-negative controls vs population controls; CRC cis rs11574514 1.000 rs16957590 chr16:67934725 C/T cg26727032 chr16:67993705 SLC12A4 0.61 5.6 0.3 4.43e-8 Crohn's disease; CRC cis rs3996993 0.809 rs2397112 chr6:52684333 A/G cg20803780 chr6:52668592 GSTA1 0.36 6.37 0.33 6.41e-10 Hemoglobin concentration; CRC trans rs1908814 0.516 rs56102998 chr8:11796675 G/A cg06636001 chr8:8085503 FLJ10661 0.47 6.95 0.36 2.01e-11 Neuroticism; CRC cis rs736408 0.812 rs6778329 chr3:52824610 G/A cg10802521 chr3:52805072 NEK4 -0.49 -6.99 -0.36 1.57e-11 Bipolar disorder; CRC cis rs6674176 0.628 rs4660759 chr1:44432500 C/G cg15962314 chr1:44399869 ARTN 0.3 5.76 0.3 1.94e-8 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Cognitive ability; CRC cis rs9902453 0.967 rs9913074 chr17:28481199 T/C cg26525008 chr17:28256777 EFCAB5;SSH2 0.6 9.49 0.46 5.04e-19 Coffee consumption (cups per day); CRC cis rs798554 0.797 rs1182184 chr7:2872446 G/A cg14895029 chr7:2775587 GNA12 -0.42 -6.07 -0.32 3.49e-9 Height; CRC cis rs13082711 0.911 rs11717669 chr3:27458484 C/T cg02860705 chr3:27208620 NA 0.6 8.05 0.41 1.5e-14 Systolic blood pressure;Diastolic blood pressure;Blood pressure; CRC cis rs1348850 0.757 rs2166554 chr2:178455824 A/G cg02961200 chr2:178257176 LOC100130691;AGPS 0.48 6.91 0.36 2.46e-11 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs9858542 1.000 rs11718165 chr3:49696797 A/G cg07274523 chr3:49395745 GPX1 0.46 6.04 0.32 4.21e-9 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC trans rs2243480 1.000 rs58062456 chr7:65394852 G/T cg10756647 chr7:56101905 PSPH 0.73 8.07 0.41 1.36e-14 Diabetic kidney disease; CRC cis rs1552244 1.000 rs7619340 chr3:10108178 C/T cg02579736 chr3:10068473 FANCD2;CIDECP 1.04 13.74 0.6 3e-34 Alzheimer's disease; CRC cis rs4638749 0.677 rs13389470 chr2:108806301 C/G cg25838818 chr2:108905173 SULT1C2 -0.34 -5.78 -0.3 1.7e-8 Blood pressure; CRC cis rs11677416 1.000 rs59674541 chr2:113553824 A/T cg27083787 chr2:113543245 IL1A 0.45 6.23 0.33 1.39e-9 Response to antipsychotic treatment in schizophrenia (working memory); CRC cis rs4713118 0.869 rs10214440 chr6:27702440 A/C cg06470822 chr6:28175283 NA 0.72 10.05 0.48 6.64e-21 Parkinson's disease; CRC cis rs6815814 0.950 rs5743565 chr4:38805983 T/C cg06935464 chr4:38784597 TLR10 0.57 5.97 0.31 6.19e-9 Breast cancer; CRC cis rs2243480 1.000 rs4149468 chr7:65825690 T/C cg25985355 chr7:65971099 NA -0.51 -5.89 -0.31 9.36e-9 Diabetic kidney disease; CRC cis rs7487075 0.619 rs4768725 chr12:46848478 T/C cg22049899 chr12:47219821 SLC38A4 0.32 5.83 0.31 1.35e-8 Itch intensity from mosquito bite; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg00531400 chr12:125348358 SCARB1 0.39 6.5 0.34 2.93e-10 Liver disease severity in Alagille syndrome; CRC trans rs57221529 0.664 rs72704802 chr5:554211 C/T cg25482853 chr8:67687455 SGK3 1.25 15.16 0.64 9.75e-40 Lung disease severity in cystic fibrosis; CRC trans rs13046373 0.905 rs4816372 chr21:32077414 A/T ch.2.235177505R chr2:235512766 NA -0.42 -6.16 -0.32 2.12e-9 HDL cholesterol; CRC cis rs7937682 0.924 rs10891283 chr11:111527672 A/G cg19812747 chr11:111475976 SIK2 -0.58 -10.08 -0.49 5.38e-21 Primary sclerosing cholangitis; CRC cis rs780096 0.526 rs1260342 chr2:27663416 G/T cg12000995 chr2:27665139 KRTCAP3 -0.32 -6.75 -0.35 6.69e-11 Total body bone mineral density; CRC cis rs853679 0.574 rs1233705 chr6:28166447 C/G cg06470822 chr6:28175283 NA 1.01 15.38 0.65 1.29e-40 Depression; CRC cis rs7191700 0.583 rs243314 chr16:11385104 G/C cg00044050 chr16:11439710 C16orf75 0.57 8.53 0.43 5.24e-16 Multiple sclerosis; CRC cis rs2239547 0.657 rs2071040 chr3:52864860 A/G cg18404041 chr3:52824283 ITIH1 -0.45 -8.25 -0.41 3.9e-15 Schizophrenia; CRC cis rs17376456 0.877 rs7734897 chr5:93305402 G/A cg21475434 chr5:93447410 FAM172A 0.79 8.19 0.41 5.81e-15 Diabetic retinopathy; CRC cis rs919433 0.963 rs12469546 chr2:198178826 T/C cg10820045 chr2:198174542 NA -0.54 -9.31 -0.46 1.82e-18 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC trans rs11039798 0.920 rs11039940 chr11:48716316 C/T cg03929089 chr4:120376271 NA 0.63 6.06 0.32 3.73e-9 Axial length; CRC cis rs477692 1.000 rs554792 chr10:131423181 A/G cg05714579 chr10:131428358 MGMT 0.55 8.13 0.41 8.91e-15 Response to temozolomide; CRC cis rs933688 1.000 rs2059208 chr5:90732065 A/T cg26981201 chr5:90679533 LOC100129716;ARRDC3 1.01 18.05 0.71 4.12e-51 Smoking behavior; CRC cis rs2580764 0.503 rs2972097 chr2:55267545 T/C cg09592903 chr2:55203963 RTN4 0.63 10.28 0.49 1.11e-21 Mean platelet volume; CRC cis rs40363 0.645 rs1690449 chr16:3520893 C/G cg22508957 chr16:3507546 NAT15 0.62 9.69 0.47 1.1e-19 Tuberculosis; CRC cis rs116095464 0.558 rs1812843 chr5:267658 A/G cg22496380 chr5:211416 CCDC127 -0.91 -10.42 -0.5 3.78e-22 Breast cancer; CRC cis rs13191362 1.000 rs34918316 chr6:163005386 A/G cg06582575 chr6:163149167 PACRG;PARK2 0.77 10.59 0.5 9.54e-23 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs1552244 1.000 rs113771705 chr3:10075983 T/C cg08888203 chr3:10149979 C3orf24 0.73 10.08 0.49 5.45e-21 Alzheimer's disease; CRC cis rs9916302 0.851 rs11868029 chr17:37650304 A/G cg07936489 chr17:37558343 FBXL20 -0.82 -12.42 -0.56 2.71e-29 Glomerular filtration rate (creatinine); CRC cis rs2204008 0.744 rs11180504 chr12:38236313 C/T cg26384229 chr12:38710491 ALG10B 0.68 9.08 0.45 9.92e-18 Bladder cancer; CRC cis rs4332037 0.539 rs34809719 chr7:2028968 G/T cg13880726 chr7:1868755 MAD1L1 -0.49 -5.99 -0.31 5.45e-9 Bipolar disorder; CRC cis rs9467711 0.591 rs34351439 chr6:25833010 T/C cg08501292 chr6:25962987 TRIM38 1.14 9.98 0.48 1.12e-20 Autism spectrum disorder or schizophrenia; CRC cis rs9611519 1.000 rs9611505 chr22:41540279 T/C cg06634786 chr22:41940651 POLR3H -0.49 -6.22 -0.32 1.47e-9 Neuroticism; CRC cis rs7274811 0.744 rs34489266 chr20:32223040 A/G cg03904042 chr20:32255491 NECAB3;C20orf134 -0.46 -6.37 -0.33 6.44e-10 Height; CRC cis rs11148252 0.595 rs9526974 chr13:53251040 C/G cg20354231 chr13:53171401 NA -0.42 -6.75 -0.35 6.56e-11 Lewy body disease; CRC cis rs10982256 0.905 rs4979417 chr9:117263878 C/T cg13636371 chr9:117264095 DFNB31 0.37 7.09 0.36 8.1e-12 Bipolar disorder; CRC cis rs798554 0.679 rs1639036 chr7:2885089 G/A cg04166393 chr7:2884313 GNA12 0.53 7.32 0.37 1.86e-12 Height; CRC cis rs4713118 0.955 rs9380011 chr6:27683924 A/G cg25164649 chr6:28176230 NA 0.54 7.3 0.37 2.13e-12 Parkinson's disease; CRC cis rs4713118 0.662 rs9468277 chr6:28028390 C/A cg12172441 chr6:28176163 NA 0.55 6.94 0.36 2.03e-11 Parkinson's disease; CRC cis rs55702914 0.746 rs7588530 chr2:198146698 A/C cg10820045 chr2:198174542 NA -0.47 -8.68 -0.43 1.93e-16 Major depression and alcohol dependence; CRC cis rs7107174 0.901 rs2511159 chr11:77974193 G/T cg02023728 chr11:77925099 USP35 -0.5 -8.44 -0.42 1e-15 Testicular germ cell tumor; CRC cis rs6089584 0.507 rs6061989 chr20:60627893 C/T cg13770153 chr20:60521292 NA -0.44 -6.53 -0.34 2.43e-10 Body mass index; CRC cis rs4253772 0.591 rs6520010 chr22:46721223 G/A cg09491104 chr22:46646882 C22orf40 -0.43 -6.6 -0.34 1.67e-10 LDL cholesterol;Cholesterol, total; CRC trans rs951252 0.504 rs11734405 chr4:146081096 C/T cg03745002 chr16:52581405 TOX3 0.43 6.02 0.31 4.63e-9 Hip circumference; CRC cis rs7917772 0.502 rs2296584 chr10:104244323 T/A cg04362960 chr10:104952993 NT5C2 -0.42 -5.85 -0.31 1.18e-8 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC cis rs13118159 0.509 rs4974556 chr4:1358141 G/C cg02018176 chr4:1364513 KIAA1530 0.72 12.5 0.57 1.29e-29 Longevity; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg27484876 chr20:33872021 EIF6 0.46 6.41 0.33 5.05e-10 Anxiety disorder; CRC cis rs9309473 0.607 rs2421488 chr2:73590625 C/T cg20560298 chr2:73613845 ALMS1 -0.49 -6.46 -0.34 3.73e-10 Metabolite levels; CRC cis rs7385804 0.761 rs1734910 chr7:100309544 A/G cg16850897 chr7:100343110 ZAN 0.46 6.94 0.36 2.09e-11 Iron status biomarkers;Mean corpuscular hemoglobin;Hematocrit;Iron status biomarkers (transferrin saturation);Red blood cell count;Iron status biomarkers (iron levels);Mean corpuscular volume;Hematological parameters; CRC trans rs2431623 0.675 rs2431621 chr10:12874715 T/G cg01441497 chr3:167968476 C3orf50 -0.33 -6.06 -0.32 3.71e-9 Asymmetrical dimethylarginine levels; CRC cis rs1552244 0.882 rs13074282 chr3:10024699 T/G cg00166722 chr3:10149974 C3orf24 0.61 7.92 0.4 3.81e-14 Alzheimer's disease; CRC cis rs7103648 1.000 rs7947450 chr11:47429904 G/A cg20307385 chr11:47447363 PSMC3 0.99 18.2 0.71 1.09e-51 Diastolic blood pressure;Systolic blood pressure; CRC cis rs7216064 1.000 rs9913471 chr17:65874495 C/T cg12091567 chr17:66097778 LOC651250 -0.61 -7.68 -0.39 1.84e-13 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CRC cis rs10504073 0.647 rs4873098 chr8:50021041 T/C cg00325661 chr8:49890786 NA 0.42 7.51 0.38 5.6e-13 Blood metabolite ratios; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg04780126 chr11:65029484 POLA2 0.42 6.12 0.32 2.72e-9 Intelligence (multi-trait analysis); CRC cis rs68170813 0.559 rs12533767 chr7:106860245 A/C cg02696742 chr7:106810147 HBP1 -0.6 -6.58 -0.34 1.83e-10 Coronary artery disease; CRC cis rs801193 0.904 rs4718403 chr7:66242729 C/G cg25985355 chr7:65971099 NA -0.32 -5.66 -0.3 3.38e-8 Aortic root size; CRC cis rs1865760 0.566 rs2032443 chr6:26046802 A/G cg16482183 chr6:26056742 HIST1H1C 0.52 7.54 0.38 4.74e-13 Height; CRC cis rs9322193 0.923 rs7767622 chr6:150002902 T/C cg13206674 chr6:150067644 NUP43 0.65 9.76 0.47 6.08e-20 Lung cancer; CRC cis rs9487051 0.735 rs1761608 chr6:109517706 G/A cg21918786 chr6:109611834 NA -0.35 -6.05 -0.32 3.9e-9 Reticulocyte fraction of red cells; CRC cis rs3736485 0.966 rs12592889 chr15:51795172 G/A cg08986416 chr15:51914746 DMXL2 -0.41 -5.94 -0.31 7.26e-9 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs8078723 0.690 rs3785549 chr17:38149724 T/C cg17467752 chr17:38218738 THRA -0.57 -9.13 -0.45 6.89e-18 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); CRC trans rs948562 0.947 rs7482383 chr11:58369698 A/G cg26660744 chr1:1573181 CDK11B 0.55 6.16 0.32 2.15e-9 Lymphoma; CRC cis rs4713118 0.662 rs149961 chr6:28015569 A/C cg23161317 chr6:28129485 ZNF389 0.44 5.78 0.3 1.76e-8 Parkinson's disease; CRC cis rs28386778 0.897 rs7212196 chr17:61834981 T/C cg11494091 chr17:61959527 GH2 0.63 10.63 0.51 7.05e-23 Prudent dietary pattern; CRC cis rs1707322 1.000 rs6671754 chr1:46433990 A/G cg06784218 chr1:46089804 CCDC17 0.51 8.96 0.44 2.39e-17 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs6570726 0.791 rs408443 chr6:145874643 T/C cg05347473 chr6:146136440 FBXO30 0.4 6.1 0.32 2.93e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs9372498 0.536 rs62422228 chr6:118957276 T/C cg22561889 chr6:118971681 C6orf204 0.52 6.58 0.34 1.91e-10 Diastolic blood pressure; CRC cis rs12541635 0.966 rs62527363 chr8:107024258 A/G cg10147462 chr8:107024639 NA 0.46 7.78 0.39 9.16e-14 Age of smoking initiation; CRC cis rs8031584 0.678 rs3122 chr15:31170290 A/T cg08109568 chr15:31115862 NA 0.65 10.23 0.49 1.61e-21 Huntington's disease progression; CRC cis rs3862030 0.720 rs3740415 chr10:104232716 G/A cg11453585 chr10:104263688 ACTR1A;SUFU -0.76 -13.31 -0.59 1.26e-32 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for body mass index; CRC cis rs7727544 0.584 rs7714191 chr5:131341541 C/G cg04518342 chr5:131593106 PDLIM4 0.34 5.86 0.31 1.11e-8 Blood metabolite levels; CRC cis rs2108622 0.711 rs113343664 chr19:15978993 G/C cg13772218 chr19:15982569 NA 0.48 6.76 0.35 6.46e-11 Circulating phylloquinone levels;Vitamin E levels;Acenocoumarol maintenance dosage;Response to Vitamin E supplementation;Metabolite levels;Warfarin maintenance dose; CRC cis rs1799949 1.000 rs8176234 chr17:41219780 T/C cg19454999 chr17:41278357 BRCA1;NBR2 0.54 8.46 0.42 8.99e-16 Menopause (age at onset); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg21788396 chr15:78423938 CIB2 0.41 6.76 0.35 6.37e-11 Liver disease severity in Alagille syndrome; CRC cis rs11997175 1.000 rs10453046 chr8:33773179 T/C cg04338863 chr8:33670619 NA 0.36 5.69 0.3 2.78e-8 Body mass index; CRC cis rs73815153 0.546 rs6869019 chr5:180483973 G/T cg00050152 chr5:180479829 BTNL9 0.56 5.97 0.31 6.11e-9 GIP levels in response to oral glucose tolerance test (120 minutes); CRC cis rs9549367 0.826 rs35306827 chr13:113869045 G/A cg00898013 chr13:113819073 PROZ -0.44 -6.36 -0.33 6.77e-10 Platelet distribution width; CRC cis rs1003719 0.667 rs2835606 chr21:38490851 G/C cg10648535 chr21:38446584 PIGP;TTC3 0.47 6.28 0.33 1.09e-9 Eye color traits; CRC cis rs7666738 0.830 rs10012271 chr4:99065154 A/C cg05340658 chr4:99064831 C4orf37 0.6 9.29 0.46 2.1e-18 Colonoscopy-negative controls vs population controls; CRC cis rs2268241 0.938 rs9978166 chr21:34770516 A/G cg14850771 chr21:34775459 IFNGR2 0.81 10.46 0.5 2.7e-22 Obesity-related traits; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg07035315 chr22:18483421 MICAL3 0.38 6.01 0.31 4.84e-9 Response to antipsychotic treatment; CRC cis rs861020 0.563 rs61820640 chr1:210041297 G/T cg05527609 chr1:210001259 C1orf107 -0.9 -10.43 -0.5 3.52e-22 Orofacial clefts; CRC cis rs1865760 1.000 rs6910174 chr6:25904414 C/T cg17691542 chr6:26056736 HIST1H1C 0.56 8.39 0.42 1.45e-15 Height; CRC cis rs7772486 0.594 rs6901864 chr6:146023050 C/A cg23711669 chr6:146136114 FBXO30 -0.73 -12.04 -0.55 6.8e-28 Lobe attachment (rater-scored or self-reported); CRC cis rs863345 0.604 rs12133791 chr1:158506682 C/A cg12129480 chr1:158549410 OR10X1 -0.3 -6.27 -0.33 1.12e-9 Pneumococcal bacteremia; CRC cis rs6502050 0.842 rs8080305 chr17:80074516 A/C cg09264619 chr17:80180166 NA 0.35 5.86 0.31 1.12e-8 Life satisfaction; CRC cis rs79349575 0.691 rs28528789 chr17:46986616 C/T cg22482690 chr17:47019901 SNF8 -0.43 -6.95 -0.36 2e-11 Type 2 diabetes; CRC cis rs6952808 0.717 rs12534679 chr7:1926745 G/A cg00106254 chr7:1943704 MAD1L1 -0.38 -5.98 -0.31 5.92e-9 Bipolar disorder and schizophrenia; CRC trans rs11039798 0.588 rs11039855 chr11:48610091 A/G cg15704280 chr7:45808275 SEPT13 0.65 6.84 0.35 3.95e-11 Axial length; CRC cis rs1799949 1.000 rs16940 chr17:41245237 A/G cg25072359 chr17:41440525 NA 0.44 6.49 0.34 3.25e-10 Menopause (age at onset); CRC cis rs35306767 0.903 rs11253460 chr10:887382 C/G cg26597838 chr10:835615 NA 0.92 10.93 0.52 6.12e-24 Eosinophil percentage of granulocytes; CRC trans rs10242455 0.557 rs59672032 chr7:99058697 T/C cg09045935 chr12:6379348 NA 1.01 8.76 0.43 1.05e-16 Blood metabolite levels; CRC cis rs9649213 0.593 rs6955647 chr7:98004562 T/C cg21770322 chr7:97807741 LMTK2 0.51 8.29 0.42 2.98e-15 Prostate cancer (SNP x SNP interaction); CRC cis rs853679 0.513 rs13437444 chr6:28070998 C/T cg02683197 chr6:28174875 NA 0.7 6.77 0.35 6.06e-11 Depression; CRC cis rs921968 0.541 rs832798 chr2:219464810 G/A cg02176678 chr2:219576539 TTLL4 0.54 8.62 0.43 2.78e-16 Mean corpuscular hemoglobin concentration; CRC cis rs6951245 1.000 rs78523927 chr7:1089458 T/C cg22907277 chr7:1156413 C7orf50 0.71 7.23 0.37 3.34e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs11785400 0.793 rs9297972 chr8:143723660 C/T cg24634471 chr8:143751801 JRK 0.51 7.08 0.36 8.81e-12 Schizophrenia; CRC cis rs995000 0.931 rs1690766 chr1:62987289 T/C cg19896129 chr1:63156450 NA -0.45 -6.94 -0.36 2.07e-11 Triglyceride levels; CRC cis rs727563 0.555 rs5751136 chr22:42075581 T/A cg06634786 chr22:41940651 POLR3H 0.51 6.12 0.32 2.66e-9 Crohn's disease;Inflammatory bowel disease; CRC cis rs926938 0.584 rs1299780 chr1:115366014 G/A cg12756093 chr1:115239321 AMPD1 0.57 8.36 0.42 1.78e-15 Autism; CRC cis rs9894429 0.646 rs7405937 chr17:79597811 G/A cg13777783 chr17:79615861 NA -0.3 -5.7 -0.3 2.6e-8 Eye color traits; CRC cis rs12824058 0.831 rs4759450 chr12:130812732 G/A cg26677194 chr12:130822605 PIWIL1 0.45 7.18 0.37 4.53e-12 Menopause (age at onset); CRC cis rs6502050 0.799 rs7501461 chr17:80109806 C/T cg02741985 chr17:80059408 CCDC57 0.43 7.15 0.37 5.66e-12 Life satisfaction; CRC cis rs826838 1.000 rs1684395 chr12:39083161 T/G cg26384229 chr12:38710491 ALG10B -0.61 -9.58 -0.47 2.49e-19 Heart rate; CRC cis rs62064224 0.714 rs4794915 chr17:30634363 A/G cg09324608 chr17:30823087 MYO1D -0.37 -6.43 -0.33 4.38e-10 Schizophrenia; CRC cis rs9322193 1.000 rs58189451 chr6:149921388 G/A cg00933542 chr6:150070202 PCMT1 0.31 6.13 0.32 2.52e-9 Lung cancer; CRC cis rs6752107 0.935 rs10199278 chr2:234160669 C/G cg07618928 chr2:234183455 ATG16L1;SCARNA5 0.65 11.38 0.53 1.54e-25 Crohn's disease;Inflammatory bowel disease; CRC cis rs7769051 1.000 rs5006218 chr6:133126220 T/G cg22852734 chr6:133119734 C6orf192 0.99 12.34 0.56 5.12e-29 Type 2 diabetes nephropathy; CRC cis rs28386778 0.897 rs896064 chr17:61860932 C/T cg25654072 chr17:61904446 PSMC5;FTSJ3 0.74 11.57 0.54 3.39e-26 Prudent dietary pattern; CRC cis rs8023845 1.000 rs62019997 chr15:40443476 T/C cg20259534 chr15:40453036 BUB1B 0.52 5.72 0.3 2.36e-8 Chronic lymphocytic leukemia; CRC cis rs812925 0.512 rs1177309 chr2:61385248 A/G cg10580144 chr2:61372316 C2orf74 0.35 7.9 0.4 4.33e-14 Immature fraction of reticulocytes; CRC cis rs738322 0.967 rs133024 chr22:38574066 C/T cg17652424 chr22:38574118 PLA2G6 0.22 7.01 0.36 1.35e-11 Cutaneous nevi; CRC cis rs9309711 0.643 rs4264589 chr2:3481098 G/T cg15541040 chr2:3486749 NA -0.52 -8.4 -0.42 1.33e-15 Neurofibrillary tangles; CRC cis rs2075371 1.000 rs2244694 chr7:133987093 C/T cg20476274 chr7:133979776 SLC35B4 0.8 14.55 0.63 2.29e-37 Mean platelet volume; CRC cis rs62244186 0.659 rs56231820 chr3:44530329 C/T cg18165381 chr3:44552316 NA -0.38 -5.64 -0.3 3.72e-8 Depressive symptoms; CRC cis rs4665809 0.590 rs4665837 chr2:26434022 C/A cg27170947 chr2:26402098 FAM59B -0.62 -8.04 -0.41 1.62e-14 Gut microbiome composition (summer); CRC cis rs4713118 0.662 rs464312 chr6:27967591 T/A cg12273811 chr6:28175739 NA 0.6 8.82 0.44 7e-17 Parkinson's disease; CRC trans rs10496992 0.966 rs16825776 chr2:146683517 A/G cg07441565 chr10:81107090 PPIF -0.43 -6.18 -0.32 1.91e-9 Serum thyroid-stimulating hormone levels; CRC trans rs1900442 0.536 rs1815346 chr13:42547580 A/G cg16734191 chr21:40194848 ETS2 0.36 6.0 0.31 5.21e-9 Tuberculosis; CRC cis rs4713118 0.866 rs2179094 chr6:27741825 T/C cg02683197 chr6:28174875 NA 0.68 8.88 0.44 4.51e-17 Parkinson's disease; CRC cis rs736408 0.509 rs13083798 chr3:52649748 A/G cg07507251 chr3:52567010 NT5DC2 0.43 6.54 0.34 2.3e-10 Bipolar disorder; CRC cis rs10788264 0.518 rs1028632 chr10:124044657 C/G cg09507567 chr10:124027408 NA 0.34 7.37 0.38 1.37e-12 Total body bone mineral density; CRC cis rs12142240 0.698 rs10158236 chr1:46820896 G/T cg00530320 chr1:46809349 NSUN4 0.59 8.03 0.41 1.69e-14 Menopause (age at onset); CRC cis rs9910055 0.607 rs13726 chr17:42239561 C/T cg13607699 chr17:42295918 UBTF 0.45 6.11 0.32 2.74e-9 Total body bone mineral density; CRC cis rs10504229 1.000 rs17805332 chr8:58169798 A/G cg05313129 chr8:58192883 C8orf71 -0.48 -7.36 -0.38 1.51e-12 Developmental language disorder (linguistic errors); CRC cis rs7937682 0.575 rs7127010 chr11:111770782 C/T cg09085632 chr11:111637200 PPP2R1B 0.94 15.53 0.65 3.42e-41 Primary sclerosing cholangitis; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg19645734 chr12:49582919 TUBA1A -0.39 -6.11 -0.32 2.78e-9 Myopia (pathological); CRC cis rs1387259 0.929 rs2634666 chr12:48663670 G/T cg21466736 chr12:48725269 NA -0.55 -8.18 -0.41 6.36e-15 Obstructive sleep apnea trait (apnea hypopnea index); CRC cis rs6997458 0.606 rs1493302 chr8:86349280 T/C cg21346043 chr8:86351067 CA3 -0.27 -5.97 -0.31 6.25e-9 Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; CRC cis rs2257205 0.588 rs7219856 chr17:56941020 C/T cg25885038 chr17:56607967 SEPT4 -0.53 -5.82 -0.31 1.43e-8 Pancreatic cancer; CRC cis rs1997103 1.000 rs6957984 chr7:55397331 G/A cg17469321 chr7:55412551 NA 0.74 11.4 0.53 1.38e-25 QRS interval (sulfonylurea treatment interaction); CRC trans rs6950442 0.505 rs6953335 chr7:114341005 A/T cg08672999 chr19:52675203 ZNF836 0.57 6.68 0.35 1.04e-10 Body mass index; CRC cis rs7811142 0.830 rs6979910 chr7:99940630 A/C cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.15 17.07 0.69 3e-47 Platelet count; CRC cis rs6662572 0.737 rs55765474 chr1:46401170 G/T cg03123370 chr1:45965343 CCDC163P;MMACHC 0.44 5.63 0.3 3.91e-8 Blood protein levels; CRC cis rs10876993 0.855 rs1678520 chr12:58049319 C/G cg15848620 chr12:58087721 OS9 -0.65 -8.97 -0.44 2.24e-17 Celiac disease or Rheumatoid arthritis; CRC cis rs9902453 0.899 rs8067580 chr17:28471248 C/T cg26525008 chr17:28256777 EFCAB5;SSH2 0.59 9.2 0.45 4.18e-18 Coffee consumption (cups per day); CRC cis rs8177253 0.665 rs6774822 chr3:133442012 G/T cg24879335 chr3:133465180 TF 0.32 5.88 0.31 9.98e-9 Iron status biomarkers; CRC cis rs763121 0.962 rs6001193 chr22:39074737 A/G cg06544989 chr22:39130855 UNC84B 0.47 7.62 0.39 2.69e-13 Menopause (age at onset); CRC cis rs758324 0.947 rs559971 chr5:131316164 A/G cg06307176 chr5:131281290 NA 0.4 6.09 0.32 3.21e-9 Alzheimer's disease in APOE e4- carriers; CRC cis rs7811142 1.000 rs60844404 chr7:100080474 A/T cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.16 17.05 0.68 3.64e-47 Platelet count; CRC cis rs7538876 1.000 rs2526828 chr1:17729903 G/A cg07965774 chr1:17746286 RCC2 0.3 5.7 0.3 2.73e-8 Basal cell carcinoma; CRC cis rs9902453 0.874 rs11653805 chr17:28378276 C/T cg26525008 chr17:28256777 EFCAB5;SSH2 -0.69 -11.35 -0.53 2.01e-25 Coffee consumption (cups per day); CRC cis rs9322193 0.923 rs1413654 chr6:150105092 G/A cg07701084 chr6:150067640 NUP43 0.47 6.61 0.34 1.51e-10 Lung cancer; CRC cis rs2153535 0.521 rs6939827 chr6:8461360 C/G cg21535247 chr6:8435926 SLC35B3 0.5 7.58 0.39 3.54e-13 Motion sickness; CRC trans rs1814175 0.645 rs847632 chr11:49926097 C/T cg15704280 chr7:45808275 SEPT13 -0.94 -16.66 -0.68 1.23e-45 Height; CRC cis rs34779708 0.931 rs3740083 chr10:35320383 C/T cg03585969 chr10:35415529 CREM 0.59 7.86 0.4 5.38e-14 Inflammatory bowel disease;Crohn's disease; CRC cis rs1552244 1.000 rs17032299 chr3:10087638 C/T cg18598329 chr3:10140678 FANCD2;C3orf24 -0.84 -11.32 -0.53 2.59e-25 Alzheimer's disease; CRC cis rs679087 1.000 rs302321 chr12:29928388 A/C cg14258853 chr12:29935411 TMTC1 0.45 7.86 0.4 5.45e-14 Schizophrenia; CRC cis rs6964587 0.967 rs10231496 chr7:91741132 T/C cg17063962 chr7:91808500 NA 0.84 14.86 0.63 1.42e-38 Breast cancer; CRC cis rs6484504 0.576 rs158139 chr11:31216076 C/T cg14844989 chr11:31128820 NA -0.34 -6.04 -0.32 4.06e-9 Red blood cell count; CRC cis rs4363385 0.818 rs11205166 chr1:152988627 C/G cg25856811 chr1:152973957 SPRR3 -0.24 -6.73 -0.35 7.68e-11 Inflammatory skin disease; CRC cis rs344364 0.511 rs2982452 chr16:1949511 G/A cg14074117 chr16:1909714 C16orf73 0.41 5.66 0.3 3.28e-8 Glomerular filtration rate in chronic kidney disease; CRC cis rs7945705 0.902 rs7479407 chr11:9023421 C/T cg12365402 chr11:9010492 NRIP3 0.53 9.03 0.45 1.53e-17 Hemoglobin concentration; CRC cis rs8177253 0.665 rs9869257 chr3:133451412 G/T cg01448562 chr3:133502909 NA -0.39 -6.23 -0.32 1.41e-9 Iron status biomarkers; CRC cis rs8040855 0.575 rs12912860 chr15:85573498 T/C cg10818794 chr15:86012489 AKAP13 -0.45 -5.94 -0.31 7.37e-9 Bulimia nervosa; CRC cis rs875971 0.660 rs10950044 chr7:66042976 A/G cg11764359 chr7:65958608 NA -0.55 -8.65 -0.43 2.36e-16 Aortic root size; CRC trans rs2243480 0.803 rs403089 chr7:65517723 T/C cg10756647 chr7:56101905 PSPH 0.75 7.66 0.39 2.05e-13 Diabetic kidney disease; CRC cis rs6735179 0.648 rs6706107 chr2:1761661 C/A cg19300414 chr2:1746591 PXDN 0.35 6.13 0.32 2.51e-9 Response to antipsychotic treatment; CRC cis rs62244186 0.748 rs12635624 chr3:44678498 G/A cg10263370 chr3:44754102 ZNF502 -0.38 -6.29 -0.33 9.93e-10 Depressive symptoms; CRC cis rs11608355 0.515 rs7310945 chr12:109946012 G/A cg05360138 chr12:110035743 NA 0.77 8.66 0.43 2.14e-16 Neuroticism; CRC cis rs10744422 1.000 rs7309225 chr12:123288439 A/G cg25930673 chr12:123319894 HIP1R -0.61 -6.08 -0.32 3.24e-9 Schizophrenia; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg04713951 chr22:38966166 DMC1 0.39 6.32 0.33 8.34e-10 Liver disease severity in Alagille syndrome; CRC cis rs932287 0.666 rs10840161 chr11:9053824 G/A cg21881798 chr11:8931708 C11orf17;ST5 0.5 7.25 0.37 2.94e-12 Colonoscopy-negative controls vs population controls; CRC cis rs7833790 0.777 rs10958042 chr8:82678393 G/T cg17211192 chr8:82754475 SNX16 -0.51 -6.4 -0.33 5.44e-10 Diastolic blood pressure; CRC cis rs427941 0.632 rs201480 chr7:101747575 A/G cg06246474 chr7:101738831 CUX1 0.44 6.75 0.35 6.62e-11 Plasma omega-3 polyunsaturated fatty acid level (eicosapentaenoic acid); CRC cis rs13191362 1.000 rs35820211 chr6:163046252 C/T cg14584255 chr6:163149320 PACRG;PARK2 0.42 5.96 0.31 6.41e-9 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC trans rs9467711 0.606 rs9379901 chr6:26603866 T/C cg06606381 chr12:133084897 FBRSL1 -0.85 -6.44 -0.33 4.18e-10 Autism spectrum disorder or schizophrenia; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg27004975 chr16:87984542 BANP 0.43 6.18 0.32 1.94e-9 Intelligence (multi-trait analysis); CRC cis rs950880 0.593 rs887971 chr2:103041167 T/C cg03938978 chr2:103052716 IL18RAP -0.41 -5.79 -0.3 1.63e-8 Serum protein levels (sST2); CRC cis rs7811142 1.000 rs2406255 chr7:100053690 T/C cg21679810 chr7:100027352 MEPCE;ZCWPW1 1.0 13.17 0.59 4.11e-32 Platelet count; CRC cis rs2749592 0.531 rs1208559 chr10:38221370 T/C cg25517755 chr10:38738941 LOC399744 0.46 6.6 0.34 1.62e-10 Age-related hearing impairment (SNP x SNP interaction); CRC trans rs10982213 0.830 rs2274163 chr9:117188714 C/T cg16487852 chr16:83841511 HSBP1 0.42 6.89 0.36 2.86e-11 Interleukin-6 levels; CRC cis rs9818758 0.607 rs3923475 chr3:49055788 G/T cg00383909 chr3:49044727 WDR6 1.3 12.44 0.57 2.13e-29 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; CRC cis rs13394619 0.935 rs12468019 chr2:11725049 T/C cg07314298 chr2:11723111 GREB1 -0.47 -7.9 -0.4 4.26e-14 Endometriosis; CRC cis rs1580019 0.961 rs4357201 chr7:32496333 T/C cg06627557 chr7:32535165 LSM5;AVL9 0.71 11.04 0.52 2.57e-24 Cognitive ability; CRC cis rs875971 0.964 rs2161065 chr7:65932905 A/G cg12463550 chr7:65579703 CRCP 0.48 6.78 0.35 5.54e-11 Aortic root size; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg14616479 chr3:155588124 GMPS 0.46 6.46 0.34 3.72e-10 Response to antipsychotic treatment; CRC cis rs6088590 0.603 rs6579186 chr20:33282198 G/C cg24642439 chr20:33292090 TP53INP2 0.47 8.11 0.41 1.03e-14 Coronary artery disease; CRC cis rs11148252 0.538 rs2408611 chr13:52709742 C/T cg12458913 chr13:53173898 NA 0.46 6.81 0.35 4.55e-11 Lewy body disease; CRC cis rs9372498 0.536 rs9489458 chr6:118920503 G/A cg15382696 chr6:118971807 C6orf204 0.6 7.72 0.39 1.38e-13 Diastolic blood pressure; CRC cis rs7246657 0.943 rs9304566 chr19:37845504 T/C cg23950597 chr19:37808831 NA -0.54 -6.5 -0.34 2.93e-10 Coronary artery calcification; CRC cis rs2976388 0.507 rs7813604 chr8:143838062 G/A cg05569086 chr8:143859399 LYNX1 0.52 8.93 0.44 3.06e-17 Urinary tract infection frequency; CRC cis rs6952808 0.929 rs11761270 chr7:1923695 C/T cg20295408 chr7:1910781 MAD1L1 -0.43 -6.06 -0.32 3.67e-9 Bipolar disorder and schizophrenia; CRC cis rs11098499 0.863 rs1155576 chr4:120450159 A/C cg24375607 chr4:120327624 NA 0.47 7.06 0.36 9.94e-12 Corneal astigmatism; CRC cis rs1008375 1.000 rs10805357 chr4:17652352 G/A cg04450456 chr4:17643702 FAM184B 0.41 6.7 0.35 8.83e-11 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs4862750 0.914 rs9998558 chr4:187874691 A/G cg22105103 chr4:187893119 NA 0.61 11.1 0.52 1.51e-24 Lobe attachment (rater-scored or self-reported); CRC cis rs736408 0.609 rs13082208 chr3:52781539 T/G cg18099408 chr3:52552593 STAB1 -0.44 -7.15 -0.37 5.62e-12 Bipolar disorder; CRC cis rs9311474 0.629 rs7639267 chr3:52568805 G/T cg01758942 chr3:52551074 STAB1 0.31 6.01 0.31 4.9e-9 Electroencephalogram traits; CRC cis rs4665809 1.000 rs2891490 chr2:26325927 T/C cg22920501 chr2:26401640 FAM59B -0.52 -7.13 -0.37 6.23e-12 Gut microbiome composition (summer); CRC cis rs11249608 0.548 rs6859936 chr5:178451214 T/C cg01312482 chr5:178451176 ZNF879 -0.36 -6.0 -0.31 5.09e-9 Pubertal anthropometrics; CRC cis rs9847710 0.901 rs2564937 chr3:53025859 C/T cg18404041 chr3:52824283 ITIH1 0.3 5.94 0.31 7.34e-9 Ulcerative colitis; CRC cis rs2204008 0.775 rs11514370 chr12:38305566 G/A cg13010199 chr12:38710504 ALG10B 0.46 6.33 0.33 7.88e-10 Bladder cancer; CRC cis rs853679 0.517 rs9348793 chr6:28084189 G/A cg06470822 chr6:28175283 NA 1.0 13.06 0.58 1.06e-31 Depression; CRC cis rs10946940 1.000 rs10946940 chr6:27560587 A/G cg21251018 chr6:28226885 NKAPL -0.39 -6.15 -0.32 2.21e-9 Systemic lupus erythematosus; CRC cis rs7223966 1.000 rs28463311 chr17:61919643 C/T cg05941027 chr17:61774174 LIMD2 0.34 5.87 0.31 1.06e-8 Hip circumference adjusted for BMI;Body mass index; CRC cis rs748404 0.697 rs530683 chr15:43568999 C/T cg02155558 chr15:43621948 ADAL;LCMT2 -0.43 -6.37 -0.33 6.54e-10 Lung cancer; CRC cis rs1215050 0.791 rs165237 chr4:98712029 T/C cg05340658 chr4:99064831 C4orf37 0.48 7.09 0.36 8.48e-12 Waist-to-hip ratio adjusted for body mass index; CRC cis rs4332037 0.539 rs11764590 chr7:2032803 C/T cg23422044 chr7:1970798 MAD1L1 -0.62 -7.43 -0.38 9.36e-13 Bipolar disorder; CRC cis rs7769051 1.000 rs7761365 chr6:133101561 T/A cg07930552 chr6:133119739 C6orf192 0.59 6.96 0.36 1.81e-11 Type 2 diabetes nephropathy; CRC cis rs3858526 0.959 rs4559671 chr11:5923419 C/T cg05234568 chr11:5960015 NA -0.56 -7.82 -0.4 7.24e-14 DNA methylation (variation); CRC cis rs2976388 0.556 rs4736323 chr8:143830359 C/T cg10596483 chr8:143751796 JRK -0.47 -6.21 -0.32 1.57e-9 Urinary tract infection frequency; CRC cis rs6502050 0.769 rs9916231 chr17:80119645 A/G cg22110888 chr17:80059540 CCDC57 0.39 6.16 0.32 2.09e-9 Life satisfaction; CRC cis rs10771431 0.782 rs10771415 chr12:9358223 C/T cg22349387 chr12:9600060 DDX12 -0.42 -6.75 -0.35 6.81e-11 Breast size; CRC cis rs4803468 1.000 rs2288871 chr19:41917868 C/T cg09537434 chr19:41945824 ATP5SL -0.91 -18.23 -0.71 8.22e-52 Height; CRC cis rs11690935 0.959 rs10174525 chr2:172635697 T/C cg13550731 chr2:172543902 DYNC1I2 -1.06 -18.36 -0.71 2.61e-52 Schizophrenia; CRC cis rs7553864 0.966 rs1886635 chr1:87614950 G/A cg02083836 chr1:87617350 LOC339524 0.37 6.57 0.34 1.99e-10 Smoking behavior; CRC cis rs1552244 0.882 rs56224841 chr3:10044014 A/C cg00166722 chr3:10149974 C3orf24 0.61 8.0 0.4 2.17e-14 Alzheimer's disease; CRC cis rs4285028 0.948 rs12637351 chr3:121694412 A/G cg20356878 chr3:121714668 ILDR1 0.47 6.83 0.35 4.02e-11 Multiple sclerosis; CRC trans rs12478296 0.901 rs67423532 chr2:243004719 A/G cg06834434 chr14:75079333 LTBP2 0.55 6.62 0.34 1.47e-10 Obesity-related traits; CRC cis rs965469 0.779 rs6051771 chr20:3328271 A/G cg25506879 chr20:3388711 C20orf194 -0.37 -5.76 -0.3 1.91e-8 IFN-related cytopenia; CRC cis rs7927771 0.507 rs10838759 chr11:47785347 T/C cg20307385 chr11:47447363 PSMC3 0.46 6.61 0.34 1.52e-10 Subjective well-being; CRC cis rs6840360 0.593 rs6857073 chr4:152689274 A/G cg09659197 chr4:152720779 NA -0.41 -8.09 -0.41 1.14e-14 Intelligence (multi-trait analysis); CRC cis rs11122272 0.735 rs2808600 chr1:231534723 T/C cg06096015 chr1:231504339 EGLN1 0.4 6.0 0.31 5.13e-9 Hemoglobin concentration; CRC trans rs61931739 0.500 rs11836198 chr12:34552782 T/C cg26384229 chr12:38710491 ALG10B 0.6 8.78 0.44 9.08e-17 Morning vs. evening chronotype; CRC cis rs10089 1.000 rs4836363 chr5:127462737 G/C cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.72 9.97 0.48 1.28e-20 Ileal carcinoids; CRC cis rs7727544 0.735 rs272879 chr5:131670546 C/G cg11843238 chr5:131593191 PDLIM4 0.3 5.64 0.3 3.74e-8 Blood metabolite levels; CRC cis rs3617 0.625 rs3774364 chr3:52863605 G/A cg07507251 chr3:52567010 NT5DC2 0.39 5.83 0.31 1.3e-8 Red blood cell count;Autism spectrum disorder or schizophrenia; CRC cis rs35883536 1.000 rs12724990 chr1:101137030 G/A cg14515779 chr1:101123966 NA -0.41 -7.97 -0.4 2.69e-14 Monocyte count; CRC cis rs9611565 0.722 rs202635 chr22:41809637 C/T cg06481639 chr22:41940642 POLR3H 0.5 5.82 0.31 1.41e-8 Vitiligo; CRC cis rs1552244 1.000 rs12374115 chr3:10134766 A/G cg02579736 chr3:10068473 FANCD2;CIDECP -0.95 -12.52 -0.57 1.11e-29 Alzheimer's disease; CRC cis rs7666738 0.830 rs4334758 chr4:98971875 A/G cg05340658 chr4:99064831 C4orf37 0.6 9.35 0.46 1.41e-18 Colonoscopy-negative controls vs population controls; CRC trans rs916888 0.821 rs199525 chr17:44847834 T/G cg01341218 chr17:43662625 NA 0.99 10.21 0.49 1.91e-21 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs5769707 0.967 rs5770585 chr22:50007874 G/A cg10356904 chr22:49881777 NA -0.32 -6.05 -0.32 4.01e-9 Monocyte count;Monocyte percentage of white cells; CRC cis rs6963495 0.818 rs73192125 chr7:105175068 A/C cg19920283 chr7:105172520 RINT1 0.51 5.9 0.31 9e-9 Bipolar disorder (body mass index interaction); CRC cis rs752010 0.967 rs2038978 chr1:42094719 A/G cg06885757 chr1:42089581 HIVEP3 0.39 6.75 0.35 6.73e-11 Lupus nephritis in systemic lupus erythematosus; CRC cis rs10256972 0.516 rs12702081 chr7:1141528 T/C cg03188948 chr7:1209495 NA 0.44 6.31 0.33 9e-10 Longevity;Endometriosis; CRC trans rs7615952 0.512 rs2979334 chr3:125358824 G/A cg02007433 chr3:129722099 NA -0.61 -9.23 -0.45 3.33e-18 Blood pressure (smoking interaction); CRC cis rs3785574 0.962 rs62077483 chr17:61806380 C/T cg22520471 chr17:61851767 DDX42;CCDC47 0.44 6.14 0.32 2.36e-9 Height; CRC cis rs67311347 1.000 rs1119179 chr3:40424929 A/C cg09455208 chr3:40491958 NA -0.44 -8.66 -0.43 2.23e-16 Renal cell carcinoma; CRC cis rs6499129 0.558 rs7203742 chr16:67605794 A/G cg26727032 chr16:67993705 SLC12A4 0.61 7.97 0.4 2.61e-14 Waist-to-hip ratio adjusted for body mass index; CRC cis rs2839186 0.771 rs2280957 chr21:47642272 A/G cg13012494 chr21:47604986 C21orf56 -0.45 -7.13 -0.37 6.48e-12 Testicular germ cell tumor; CRC cis rs853679 0.517 rs9393898 chr6:28130376 G/T cg23161317 chr6:28129485 ZNF389 0.54 6.47 0.34 3.49e-10 Depression; CRC cis rs10256972 0.591 rs11766651 chr7:1161646 A/G cg18765753 chr7:1198926 ZFAND2A -0.37 -6.23 -0.32 1.42e-9 Longevity;Endometriosis; CRC cis rs798554 0.757 rs1182181 chr7:2873247 C/G cg13628971 chr7:2884303 GNA12 0.53 7.17 0.37 5.1e-12 Height; CRC trans rs75804782 0.641 rs72983861 chr2:239326126 G/A cg01134436 chr17:81009848 B3GNTL1 0.8 7.28 0.37 2.55e-12 Morning vs. evening chronotype;Chronotype; CRC cis rs12950390 0.853 rs11079790 chr17:45853626 G/A cg24803719 chr17:45855879 NA -0.31 -6.92 -0.36 2.34e-11 IgG glycosylation; CRC cis rs7208859 0.673 rs9907197 chr17:29018263 C/T cg13385521 chr17:29058706 SUZ12P 0.59 7.23 0.37 3.44e-12 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs4509693 0.943 rs6584393 chr10:102497206 C/G cg23167259 chr10:102495509 NA -0.46 -6.27 -0.33 1.11e-9 Alzheimer's disease; CRC cis rs939658 0.683 rs8038464 chr15:79463036 A/T cg17916960 chr15:79447300 NA -0.44 -7.13 -0.37 6.35e-12 Refractive error; CRC cis rs870825 0.616 rs28608669 chr4:185632890 T/C cg04058563 chr4:185651563 MLF1IP 0.74 9.5 0.46 4.52e-19 Blood protein levels; CRC cis rs7542091 0.648 rs688464 chr1:209992539 C/T cg22029157 chr1:209979665 IRF6 -0.58 -9.66 -0.47 1.33e-19 Monobrow; CRC cis rs67340775 0.541 rs200973 chr6:27858421 A/G cg03623178 chr6:28175578 NA 0.84 9.0 0.44 1.86e-17 Lung cancer in ever smokers; CRC cis rs688020 1.000 rs673500 chr7:4229445 C/G cg02004499 chr7:4244250 SDK1 -0.35 -5.78 -0.3 1.77e-8 Liver fibrosis in pediatric non-alcoholic fatty acid liver disease; CRC cis rs7493 0.760 rs17876092 chr7:95053313 C/A cg04155289 chr7:94953770 PON1 -0.64 -7.75 -0.39 1.13e-13 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs12612619 0.732 rs11679069 chr2:27270311 G/A cg00617064 chr2:27272375 NA -0.39 -6.49 -0.34 3.17e-10 Venous thromboembolism adjusted for sickle cell variant rs77121243-T; CRC cis rs4073582 0.595 rs708471 chr11:65931008 A/G cg14036092 chr11:66035641 RAB1B 0.55 9.01 0.44 1.68e-17 Gout; CRC cis rs2842992 0.830 rs2758320 chr6:160070676 T/G cg19482086 chr6:160211437 TCP1;MRPL18 0.69 8.67 0.43 1.97e-16 Age-related macular degeneration (geographic atrophy); CRC cis rs10751667 1.000 rs7396798 chr11:970510 G/T cg01483505 chr11:975446 AP2A2 0.41 6.23 0.32 1.46e-9 Alzheimer's disease (late onset); CRC cis rs16867335 1.000 rs72884242 chr2:181465486 A/T cg23363182 chr2:181467187 NA -0.49 -6.62 -0.34 1.45e-10 Survival in rectal cancer; CRC cis rs2976388 0.578 rs3736010 chr8:143817503 T/C cg20041105 chr8:143859282 LYNX1 -0.43 -6.69 -0.35 9.5e-11 Urinary tract infection frequency; CRC cis rs9467711 0.790 rs35162296 chr6:26318262 C/T cg12315302 chr6:26189340 HIST1H4D 0.9 6.56 0.34 2.06e-10 Autism spectrum disorder or schizophrenia; CRC cis rs4478858 0.684 rs10798839 chr1:31731758 C/G cg00250761 chr1:31883323 NA -0.44 -8.5 -0.42 6.74e-16 Alcohol dependence; CRC cis rs1335587 0.582 rs3916910 chr13:102108308 A/G cg03165014 chr13:102106348 ITGBL1 0.39 5.77 0.3 1.8e-8 Obesity-related traits; CRC cis rs644799 0.932 rs10831447 chr11:95663017 C/T cg25622487 chr11:95524042 FAM76B;CEP57 -0.54 -7.24 -0.37 3.24e-12 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs877282 0.853 rs11593836 chr10:756715 G/A cg17470449 chr10:769945 NA 0.61 7.96 0.4 2.78e-14 Uric acid levels; CRC cis rs9640161 0.789 rs60283368 chr7:150023258 G/A cg12556325 chr7:150026731 C7orf29;LRRC61 -0.39 -5.93 -0.31 7.49e-9 Blood protein levels;Circulating chemerin levels; CRC cis rs6500602 0.623 rs9929311 chr16:4510426 T/C cg08645402 chr16:4508243 NA 0.57 8.39 0.42 1.44e-15 Schizophrenia; CRC cis rs4664293 0.867 rs6720304 chr2:160643832 G/A cg08347373 chr2:160653686 CD302 -0.51 -7.99 -0.4 2.23e-14 Monocyte percentage of white cells; CRC cis rs7089973 0.668 rs61868024 chr10:116637939 A/G cg23260525 chr10:116636907 FAM160B1 0.36 7.96 0.4 2.87e-14 Bipolar disorder or attention deficit hyperactivity disorder; CRC cis rs7786808 0.504 rs10949725 chr7:158196003 C/T cg01191920 chr7:158217561 PTPRN2 0.57 9.2 0.45 4.16e-18 Obesity-related traits; CRC cis rs853679 0.517 rs35227624 chr6:28132726 A/G cg21251018 chr6:28226885 NKAPL 0.48 6.17 0.32 2.02e-9 Depression; CRC cis rs11628318 0.660 rs35258120 chr14:103058769 G/A cg23071808 chr14:103021642 NA -0.6 -7.14 -0.37 6.06e-12 Platelet count; CRC trans rs6952808 0.635 rs12154473 chr7:1982181 A/G cg04565464 chr8:145669602 NFKBIL2 -0.4 -6.1 -0.32 2.98e-9 Bipolar disorder and schizophrenia; CRC cis rs11098499 0.954 rs17006190 chr4:120418838 C/G cg24375607 chr4:120327624 NA 0.51 7.67 0.39 1.99e-13 Corneal astigmatism; CRC cis rs2842992 0.830 rs752779 chr6:160133957 G/A cg11366901 chr6:160182831 ACAT2 0.94 13.05 0.58 1.21e-31 Age-related macular degeneration (geographic atrophy); CRC cis rs7647973 0.506 rs11920251 chr3:49356671 C/T cg07636037 chr3:49044803 WDR6 0.73 11.07 0.52 1.97e-24 Menarche (age at onset); CRC cis rs12541635 0.677 rs2029879 chr8:107024695 T/A cg10147462 chr8:107024639 NA 0.58 10.66 0.51 5.31e-23 Age of smoking initiation; CRC cis rs2645694 0.626 rs2703119 chr4:77823640 C/T cg10057126 chr4:77819792 ANKRD56 0.33 5.6 0.3 4.46e-8 Emphysema distribution in smoking; CRC cis rs1448094 0.845 rs11117129 chr12:86349390 A/G cg02569458 chr12:86230093 RASSF9 0.48 8.01 0.4 2.05e-14 Major depressive disorder; CRC cis rs713477 1.000 rs12886860 chr14:55911150 G/C cg13175173 chr14:55914753 NA -0.52 -9.85 -0.48 3.19e-20 Pediatric bone mineral content (femoral neck); CRC cis rs34311866 0.748 rs10029038 chr4:899352 T/C cg14530993 chr4:882597 GAK 0.78 7.59 0.39 3.27e-13 Parkinson's disease; CRC cis rs9487051 0.872 rs1320612 chr6:109611990 C/A cg21918786 chr6:109611834 NA -0.44 -8.09 -0.41 1.14e-14 Reticulocyte fraction of red cells; CRC cis rs8067545 0.720 rs6587206 chr17:19881587 T/C cg04132472 chr17:19861366 AKAP10 0.38 6.02 0.32 4.61e-9 Schizophrenia; CRC cis rs8077889 0.956 rs4793026 chr17:41850508 A/G cg26893861 chr17:41843967 DUSP3 0.86 12.18 0.56 2.06e-28 Triglycerides; CRC cis rs7772486 0.846 rs9403767 chr6:146402386 G/T cg23711669 chr6:146136114 FBXO30 0.68 11.53 0.54 4.55e-26 Lobe attachment (rater-scored or self-reported); CRC cis rs2816062 0.735 rs2816054 chr1:18896431 C/T cg18795169 chr1:18902165 NA -0.92 -19.57 -0.73 4.36e-57 Urate levels in lean individuals; CRC cis rs2994684 0.736 rs11008385 chr10:31453788 A/C cg26784012 chr10:32216390 ARHGAP12 0.37 5.73 0.3 2.24e-8 Response to antipsychotic treatment; CRC cis rs853679 0.517 rs9393891 chr6:28079160 C/T cg06470822 chr6:28175283 NA 1.0 13.06 0.58 1.06e-31 Depression; CRC cis rs734999 0.545 rs9970196 chr1:2574078 T/C cg20673091 chr1:2541236 MMEL1 -0.38 -6.01 -0.31 5.04e-9 Ulcerative colitis; CRC cis rs7927771 0.931 rs4752801 chr11:47907641 A/G cg05585544 chr11:47624801 NA -0.55 -10.05 -0.48 6.9e-21 Subjective well-being; CRC cis rs11212617 1.000 rs1003623 chr11:108152582 C/T cg14761454 chr11:108092087 ATM;NPAT 0.42 6.15 0.32 2.28e-9 Response to metformin in type 2 diabetes (glycemic); CRC cis rs6545883 0.929 rs12612982 chr2:61747355 G/A cg15711740 chr2:61764176 XPO1 -0.51 -6.94 -0.36 2.07e-11 Tuberculosis; CRC cis rs34779708 0.931 rs34876468 chr10:35424450 G/A cg03585969 chr10:35415529 CREM 0.66 8.68 0.43 1.88e-16 Inflammatory bowel disease;Crohn's disease; CRC cis rs9768139 0.566 rs729099 chr7:158114152 C/T cg25566285 chr7:158114605 PTPRN2 0.48 7.98 0.4 2.5e-14 Calcium levels; CRC cis rs73200209 0.744 rs1136427 chr12:116608487 C/T cg01776926 chr12:116560359 MED13L -0.56 -6.19 -0.32 1.77e-9 Total body bone mineral density; CRC cis rs6564851 0.506 rs11644611 chr16:81260494 T/G cg05274606 chr16:81253692 PKD1L2 -0.37 -6.12 -0.32 2.61e-9 Carotenoid and tocopherol levels; CRC cis rs10479542 0.784 rs7702303 chr5:178986436 G/A cg19626725 chr5:178986131 RUFY1 0.37 7.41 0.38 1.08e-12 Lung cancer; CRC cis rs4819052 0.851 rs9753963 chr21:46661437 G/A cg19498844 chr21:46707878 POFUT2;LOC642852 0.77 10.99 0.52 3.97e-24 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs7959452 0.649 rs4761239 chr12:69776886 T/A cg20891283 chr12:69753455 YEATS4 0.91 16.93 0.68 1.09e-46 Blood protein levels; CRC cis rs2857891 0.817 rs2239733 chr11:6976666 T/C cg12728517 chr11:6947552 ZNF215 0.48 5.71 0.3 2.48e-8 Response to cytadine analogues (cytosine arabinoside); CRC cis rs34172651 0.517 rs2287783 chr16:24831727 C/T cg04756594 chr16:24857601 SLC5A11 0.31 6.3 0.33 9.45e-10 Intelligence (multi-trait analysis); CRC cis rs2290159 0.800 rs3773345 chr3:12642945 G/C cg23032965 chr3:12705835 RAF1 0.46 6.22 0.32 1.49e-9 Cholesterol, total; CRC trans rs1945213 0.694 rs7129022 chr11:55876132 A/G cg03929089 chr4:120376271 NA 0.58 6.53 0.34 2.52e-10 Acute lymphoblastic leukemia (childhood); CRC cis rs6062302 0.522 rs2297427 chr20:62221364 G/A cg16989086 chr20:62203971 PRIC285 0.47 6.04 0.32 4.21e-9 Glioblastoma; CRC cis rs4629710 0.545 rs3777477 chr6:131534374 T/C cg12606694 chr6:131520996 AKAP7 0.51 7.62 0.39 2.81e-13 Multiple myeloma (IgH translocation); CRC cis rs875971 0.660 rs2191268 chr7:66110224 C/T cg06586915 chr7:65958596 NA -0.42 -6.28 -0.33 1.05e-9 Aortic root size; CRC cis rs416603 0.901 rs149597 chr16:11343942 C/G cg00044050 chr16:11439710 C16orf75 -0.55 -7.7 -0.39 1.5700000000000001e-13 Type 1 diabetes; CRC cis rs13064411 0.627 rs9872168 chr3:113233132 A/C cg18753928 chr3:113234510 CCDC52 -0.69 -10.6 -0.5 9.1e-23 Response to simvastatin treatment (PCSK9 protein level change); CRC cis rs11785400 0.731 rs9720504 chr8:143725502 T/C cg24634471 chr8:143751801 JRK 0.51 7.08 0.36 8.81e-12 Schizophrenia; CRC cis rs9534288 0.664 rs1926447 chr13:46629944 C/T cg15192986 chr13:46630673 CPB2 0.69 9.94 0.48 1.56e-20 Blood protein levels; CRC cis rs6860806 0.507 rs582490 chr5:131710095 G/A cg20512303 chr5:131592959 PDLIM4 -0.39 -6.65 -0.34 1.25e-10 Breast cancer; CRC cis rs6988985 0.765 rs7824229 chr8:143984064 A/C cg10324643 chr8:143916377 GML 0.39 6.3 0.33 9.39e-10 Plasma androstenedione levels in resected early stage-receptor positive breast cancer; CRC cis rs7605827 0.930 rs4668904 chr2:15543642 C/G cg19274914 chr2:15703543 NA 0.38 5.79 0.3 1.67e-8 Educational attainment (years of education); CRC cis rs2732480 0.523 rs34286639 chr12:48629044 C/T cg04545296 chr12:48745243 ZNF641 0.35 6.1 0.32 2.96e-9 Hemoglobin concentration;Red blood cell count;Hematocrit; CRC cis rs796364 0.806 rs4673634 chr2:200863349 A/C cg25936922 chr2:200820526 C2orf60;C2orf47 0.68 6.63 0.34 1.34e-10 Schizophrenia; CRC cis rs68170813 0.559 rs60255281 chr7:106963913 C/T cg02696742 chr7:106810147 HBP1 -0.6 -6.8 -0.35 4.84e-11 Coronary artery disease; CRC cis rs992157 0.835 rs6707559 chr2:219142773 C/T cg00012203 chr2:219082015 ARPC2 0.45 6.93 0.36 2.26e-11 Colorectal cancer; CRC cis rs6921919 0.583 rs13437294 chr6:28341535 C/A cg21251018 chr6:28226885 NKAPL 0.4 6.09 0.32 3.12e-9 Autism spectrum disorder or schizophrenia; CRC cis rs12188164 0.965 rs11745789 chr5:450777 T/C cg21972741 chr5:435613 AHRR 0.55 7.56 0.38 4.15e-13 Cystic fibrosis severity; CRC cis rs28386778 0.897 rs2727328 chr17:61923564 G/A cg25654072 chr17:61904446 PSMC5;FTSJ3 0.7 10.94 0.52 5.62e-24 Prudent dietary pattern; CRC cis rs853679 0.505 rs200992 chr6:27814677 A/G cg03623178 chr6:28175578 NA 0.77 6.33 0.33 7.87e-10 Depression; CRC cis rs3213545 0.659 rs2259690 chr12:121457914 T/G cg02403541 chr12:121454288 C12orf43 0.46 7.37 0.38 1.4e-12 Subjective well-being;Cardiovascular disease risk factors; CRC cis rs3796352 1.000 rs13074524 chr3:52974184 A/G cg27565382 chr3:53032988 SFMBT1 0.65 5.74 0.3 2.2e-8 Immune reponse to smallpox (secreted IL-2); CRC cis rs9467711 0.606 rs66827971 chr6:26365766 T/C cg14345882 chr6:26364793 BTN3A2 0.65 5.74 0.3 2.17e-8 Autism spectrum disorder or schizophrenia; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg12680326 chr20:2821316 VPS16;FAM113A 0.36 6.3 0.33 9.65e-10 Liver disease severity in Alagille syndrome; CRC cis rs6121246 0.909 rs8126355 chr20:30332660 C/T cg18721089 chr20:30220636 NA -0.36 -5.86 -0.31 1.12e-8 Mean corpuscular hemoglobin; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg00345270 chr16:29268157 NA 0.41 6.04 0.32 4.2e-9 Liver disease severity in Alagille syndrome; CRC cis rs7811142 1.000 rs11764818 chr7:100043055 G/A cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.17 17.44 0.69 1.04e-48 Platelet count; CRC cis rs951366 0.617 rs708727 chr1:205767885 G/A cg07167872 chr1:205819463 PM20D1 0.98 17.67 0.7 1.29e-49 Menarche (age at onset); CRC cis rs12122100 0.507 rs1925343 chr1:146505535 A/T cg02487331 chr1:146550467 NA -0.33 -5.89 -0.31 9.38e-9 HIV-1 control; CRC trans rs7615952 0.546 rs2979350 chr3:125362215 T/C cg02007433 chr3:129722099 NA -0.5 -6.22 -0.32 1.48e-9 Blood pressure (smoking interaction); CRC cis rs2243480 1.000 rs419603 chr7:65597341 C/T cg25985355 chr7:65971099 NA -0.51 -5.87 -0.31 1.05e-8 Diabetic kidney disease; CRC cis rs1865760 0.566 rs9295686 chr6:26081983 G/C cg16482183 chr6:26056742 HIST1H1C 0.52 7.58 0.39 3.66e-13 Height; CRC cis rs6502050 0.835 rs34673303 chr17:80085144 G/C cg25804541 chr17:80189381 SLC16A3 0.31 5.9 0.31 8.94e-9 Life satisfaction; CRC cis rs2204008 0.774 rs11520273 chr12:38354075 A/T cg26384229 chr12:38710491 ALG10B 0.68 9.75 0.47 6.92e-20 Bladder cancer; CRC cis rs4638749 0.627 rs6542753 chr2:108815852 T/A cg25838818 chr2:108905173 SULT1C2 -0.34 -5.77 -0.3 1.86e-8 Blood pressure; CRC cis rs951366 0.903 rs823114 chr1:205719532 G/A cg07167872 chr1:205819463 PM20D1 0.46 6.84 0.35 3.9e-11 Menarche (age at onset); CRC cis rs4073582 0.595 rs2508657 chr11:66043898 G/A cg14036092 chr11:66035641 RAB1B 0.57 9.23 0.45 3.32e-18 Gout; CRC cis rs7618915 1.000 rs7618915 chr3:52279594 G/A cg14092988 chr3:52407081 DNAH1 0.38 6.67 0.35 1.06e-10 Bipolar disorder; CRC cis rs7937682 0.921 rs4534611 chr11:111440425 C/G cg19812747 chr11:111475976 SIK2 -0.49 -7.62 -0.39 2.75e-13 Primary sclerosing cholangitis; CRC cis rs9322193 0.923 rs4354168 chr6:150017778 C/T cg07701084 chr6:150067640 NUP43 0.56 8.29 0.42 2.92e-15 Lung cancer; CRC cis rs1448094 0.773 rs11117100 chr12:86310392 A/G cg02569458 chr12:86230093 RASSF9 0.34 5.63 0.3 3.83e-8 Major depressive disorder; CRC cis rs9910055 0.659 rs7216294 chr17:42251095 T/C cg16434002 chr17:42200994 HDAC5 -0.53 -7.62 -0.39 2.68e-13 Total body bone mineral density; CRC cis rs59918340 0.728 rs35257077 chr8:142235049 C/T cg03316587 chr8:142245164 NA 0.42 6.17 0.32 2.06e-9 Immature fraction of reticulocytes; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg01089060 chr10:97050836 PDLIM1 0.35 6.14 0.32 2.41e-9 Liver disease severity in Alagille syndrome; CRC trans rs1005277 0.579 rs2505241 chr10:38442421 T/C cg23533926 chr12:111358616 MYL2 -0.52 -7.89 -0.4 4.56e-14 Extrinsic epigenetic age acceleration; CRC cis rs7917772 0.502 rs2296583 chr10:104244322 T/G cg04362960 chr10:104952993 NT5C2 -0.42 -5.85 -0.31 1.18e-8 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC cis rs12142240 0.698 rs1057533 chr1:46815836 C/T cg00530320 chr1:46809349 NSUN4 0.57 7.75 0.39 1.19e-13 Menopause (age at onset); CRC cis rs1552244 1.000 rs9881859 chr3:10072814 A/T cg13047869 chr3:10149882 C3orf24 0.51 7.0 0.36 1.47e-11 Alzheimer's disease; CRC cis rs6500602 0.647 rs1684600 chr16:4594671 C/T cg08645402 chr16:4508243 NA -0.61 -11.06 -0.52 2.18e-24 Schizophrenia; CRC trans rs11125721 0.788 rs11125718 chr2:57800605 A/G cg20411671 chr10:1463014 ADARB2 0.4 6.22 0.32 1.5e-9 Intelligence (multi-trait analysis); CRC cis rs1223397 0.938 rs3817737 chr6:13279082 A/G cg07912922 chr6:13274314 PHACTR1 0.51 6.09 0.32 3.22e-9 Blood pressure; CRC cis rs10905065 0.965 rs7100576 chr10:5784649 G/A cg25171089 chr10:5708825 ASB13 0.42 5.87 0.31 1.07e-8 Menopause (age at onset); CRC cis rs11809207 0.523 rs2186232 chr1:26502676 T/A cg00147160 chr1:26503991 CNKSR1 0.32 6.38 0.33 6.18e-10 Height; CRC cis rs951366 0.646 rs1772159 chr1:205759195 G/A cg23034840 chr1:205782522 SLC41A1 0.55 7.44 0.38 8.73e-13 Menarche (age at onset); CRC cis rs2576037 0.526 rs9962523 chr18:44486414 A/T cg23996704 chr18:44553084 KATNAL2 -0.34 -6.78 -0.35 5.5e-11 Personality dimensions; CRC cis rs6460942 0.687 rs74753576 chr7:12463926 G/A cg20607287 chr7:12443886 VWDE -0.59 -7.3 -0.37 2.12e-12 Coronary artery disease; CRC cis rs1552244 0.882 rs13063098 chr3:10009919 G/A cg13047869 chr3:10149882 C3orf24 0.53 7.16 0.37 5.41e-12 Alzheimer's disease; CRC cis rs6582630 0.502 rs8186661 chr12:38380781 G/A cg26384229 chr12:38710491 ALG10B 0.68 9.22 0.45 3.74e-18 Drug-induced liver injury (flucloxacillin); CRC cis rs13191362 1.000 rs34697913 chr6:163000187 T/C cg21926612 chr6:163149169 PACRG;PARK2 0.8 11.25 0.53 4.59e-25 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs2836974 0.965 rs2836965 chr21:40633631 C/G cg06238570 chr21:40685208 BRWD1 -0.76 -10.48 -0.5 2.24e-22 Cognitive function; CRC cis rs4604732 0.578 rs12038656 chr1:247623816 A/G cg12758973 chr1:247694275 LOC148824;OR2C3 0.43 6.35 0.33 7.27e-10 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CRC cis rs835154 0.845 rs835155 chr5:14875868 A/G cg18064842 chr5:14874549 NA 0.53 8.22 0.41 4.82e-15 Blood metabolite levels; CRC cis rs3749237 0.964 rs13084243 chr3:49821878 G/C cg05072774 chr3:49840536 C3orf54 -0.44 -5.71 -0.3 2.55e-8 Resting heart rate; CRC cis rs9660180 0.875 rs4648727 chr1:1776269 C/A cg17747265 chr1:1875780 NA 0.63 10.62 0.51 7.72e-23 Body mass index; CRC cis rs2882667 0.858 rs11242447 chr5:138426173 T/C cg04439458 chr5:138467593 SIL1 -0.35 -6.01 -0.31 4.95e-9 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs6076065 0.723 rs16985308 chr20:23359780 A/T cg11657817 chr20:23433608 CST11 0.45 6.79 0.35 5.39e-11 Facial morphology (factor 15, philtrum width); CRC cis rs7615952 0.576 rs6804482 chr3:125815762 C/T cg05084668 chr3:125655381 ALG1L -0.46 -6.46 -0.34 3.68e-10 Blood pressure (smoking interaction); CRC cis rs12586317 0.547 rs77262907 chr14:35495734 C/G cg05294307 chr14:35346193 BAZ1A -0.69 -7.47 -0.38 7.35e-13 Psoriasis; CRC cis rs12477438 0.798 rs6732579 chr2:99560239 A/T cg14399236 chr2:99771627 LIPT1;TSGA10 -0.68 -9.47 -0.46 5.45e-19 Chronic sinus infection; CRC cis rs6747952 0.899 rs4663856 chr2:239089624 C/A cg17459225 chr2:239074497 NA 0.46 7.96 0.4 2.76e-14 Mean corpuscular hemoglobin concentration; CRC cis rs6952808 0.595 rs3778984 chr7:2166514 T/C cg02951883 chr7:2050386 MAD1L1 -0.69 -10.63 -0.51 7.02e-23 Bipolar disorder and schizophrenia; CRC cis rs6460942 1.000 rs2053381 chr7:12400710 C/A cg20607287 chr7:12443886 VWDE -0.67 -6.68 -0.35 1.01e-10 Coronary artery disease; CRC cis rs751728 0.643 rs12173787 chr6:33735471 G/C cg25922239 chr6:33757077 LEMD2 0.43 6.21 0.32 1.64e-9 Crohn's disease; CRC cis rs7119 0.651 rs12917044 chr15:77850146 A/G cg27398640 chr15:77910606 LINGO1 0.35 5.97 0.31 6.14e-9 Type 2 diabetes; CRC cis rs7829975 0.658 rs907181 chr8:8702875 T/C cg06636001 chr8:8085503 FLJ10661 0.47 7.08 0.36 8.68e-12 Mood instability; CRC cis rs9322193 0.632 rs3828700 chr6:150112169 C/G cg13206674 chr6:150067644 NUP43 0.57 8.07 0.41 1.36e-14 Lung cancer; CRC cis rs4750440 0.702 rs4750445 chr10:14030314 C/T cg00551146 chr10:14014579 FRMD4A 0.37 5.9 0.31 8.89e-9 Adiponectin levels; CRC cis rs11212617 1.000 rs650173 chr11:108174173 G/A cg01991180 chr11:108092276 ATM;NPAT 0.42 6.16 0.32 2.11e-9 Response to metformin in type 2 diabetes (glycemic); CRC cis rs13108904 0.935 rs6853002 chr4:1295991 C/T cg21620606 chr4:1342894 KIAA1530 0.38 6.61 0.34 1.59e-10 Obesity-related traits; CRC cis rs13191362 1.000 rs13210412 chr6:163019478 T/C cg06582575 chr6:163149167 PACRG;PARK2 0.74 10.54 0.5 1.48e-22 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs7945705 0.869 rs11042154 chr11:9029700 A/G cg12365402 chr11:9010492 NRIP3 -0.5 -8.06 -0.41 1.39e-14 Hemoglobin concentration; CRC cis rs6938 0.618 rs11633472 chr15:75184084 T/G cg09165964 chr15:75287851 SCAMP5 0.58 9.16 0.45 5.8e-18 Breast cancer; CRC cis rs360798 0.512 rs6545973 chr2:63089434 C/T cg17519650 chr2:63277830 OTX1 0.47 6.48 0.34 3.35e-10 Coronary artery disease; CRC cis rs7666738 0.925 rs2865952 chr4:99040305 C/T cg17366294 chr4:99064904 C4orf37 0.45 7.14 0.37 5.86e-12 Colonoscopy-negative controls vs population controls; CRC cis rs853679 0.542 rs2295594 chr6:28053097 G/A cg15845792 chr6:28175446 NA 0.97 13.08 0.58 8.89e-32 Depression; CRC cis rs7258465 0.931 rs8107351 chr19:18612758 G/A cg06462663 chr19:18546047 ISYNA1 0.46 7.04 0.36 1.15e-11 Breast cancer; CRC cis rs736408 0.505 rs2083180 chr3:52668119 G/T cg15147215 chr3:52552868 STAB1 -0.64 -11.08 -0.52 1.85e-24 Bipolar disorder; CRC trans rs459571 0.920 rs2520094 chr9:136919985 A/T cg15028160 chr19:49622717 PPFIA3;C19orf73 -0.54 -6.92 -0.36 2.31e-11 Platelet distribution width; CRC cis rs9976767 0.932 rs3746924 chr21:43826391 T/C cg23042151 chr21:43824109 UBASH3A -0.37 -6.5 -0.34 2.96e-10 Type 1 diabetes; CRC cis rs1046896 0.562 rs2380172 chr17:80887719 C/A cg17346650 chr17:80929145 B3GNTL1 0.47 6.91 0.36 2.51e-11 Glycated hemoglobin levels; CRC cis rs34172651 0.917 rs172066 chr16:24756449 C/T cg00339695 chr16:24857497 SLC5A11 0.27 6.58 0.34 1.9e-10 Intelligence (multi-trait analysis); CRC cis rs17253792 0.545 rs12879564 chr14:56017694 A/G cg01858014 chr14:56050164 KTN1 -0.86 -6.64 -0.34 1.27e-10 Putamen volume; CRC cis rs2635047 0.811 rs17785419 chr18:44765469 A/G cg19077165 chr18:44547161 KATNAL2 0.42 6.22 0.32 1.54e-9 Educational attainment; CRC cis rs3743162 0.553 rs12900463 chr15:85415386 T/C cg11189052 chr15:85197271 WDR73 0.53 7.08 0.36 8.9e-12 Alzheimer's disease (age of onset); CRC cis rs1707322 0.691 rs11211175 chr1:46220884 C/G cg03146154 chr1:46216737 IPP 0.64 9.31 0.46 1.85e-18 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs4819052 0.959 rs9976074 chr21:46655638 G/T cg19498844 chr21:46707878 POFUT2;LOC642852 0.79 9.74 0.47 7.14e-20 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs1568889 1.000 rs66702115 chr11:28181703 T/A cg06544937 chr11:28130018 METT5D1;KIF18A 0.8 11.58 0.54 3.17e-26 Bipolar disorder; CRC cis rs780096 0.546 rs2293571 chr2:27729480 C/T cg22903471 chr2:27725779 GCKR -0.35 -5.64 -0.3 3.69e-8 Total body bone mineral density; CRC cis rs12477438 0.798 rs13393860 chr2:99590397 C/T cg14399236 chr2:99771627 LIPT1;TSGA10 -0.7 -9.74 -0.47 7.45e-20 Chronic sinus infection; CRC cis rs919433 1.000 rs6741380 chr2:198165121 A/G cg20885578 chr2:198174922 NA 0.37 6.57 0.34 1.95e-10 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC cis rs362272 0.545 rs2749782 chr4:3339761 A/G cg11522145 chr4:3412961 RGS12 -0.38 -5.83 -0.31 1.35e-8 Serum sulfate level; CRC cis rs7043114 0.525 rs6479417 chr9:95064562 G/C cg14631576 chr9:95140430 CENPP -0.3 -5.76 -0.3 1.92e-8 Height; CRC cis rs9487051 0.837 rs932223 chr6:109586656 A/G cg01475377 chr6:109611718 NA -0.45 -8.36 -0.42 1.79e-15 Reticulocyte fraction of red cells; CRC cis rs501916 0.604 rs616871 chr15:48058259 T/A cg16110827 chr15:48056943 SEMA6D -0.45 -6.78 -0.35 5.74e-11 Inflammatory bowel disease;Ulcerative colitis; CRC cis rs4689592 0.503 rs3857180 chr4:7073899 T/G cg06697600 chr4:7070879 GRPEL1 0.52 6.56 0.34 2.07e-10 Monocyte percentage of white cells; CRC cis rs13108904 0.967 rs11730939 chr4:1285560 G/A cg19318889 chr4:1322082 MAEA 0.4 5.66 0.3 3.25e-8 Obesity-related traits; CRC cis rs10504229 1.000 rs17805549 chr8:58179653 T/C cg05313129 chr8:58192883 C8orf71 -0.47 -6.99 -0.36 1.49e-11 Developmental language disorder (linguistic errors); CRC cis rs9649213 0.593 rs7807555 chr7:97957517 G/A cg24562669 chr7:97807699 LMTK2 0.44 7.29 0.37 2.33e-12 Prostate cancer (SNP x SNP interaction); CRC cis rs734999 0.505 rs4648659 chr1:2560903 T/G cg18854424 chr1:2615690 NA -0.38 -7.23 -0.37 3.34e-12 Ulcerative colitis; CRC cis rs4629710 0.592 rs9492864 chr6:131531306 A/T cg12606694 chr6:131520996 AKAP7 0.6 8.79 0.44 8.19e-17 Multiple myeloma (IgH translocation); CRC cis rs7772486 0.719 rs2206141 chr6:146086192 A/G cg05347473 chr6:146136440 FBXO30 -0.38 -5.67 -0.3 3.17e-8 Lobe attachment (rater-scored or self-reported); CRC trans rs4332037 0.539 rs62444881 chr7:2052318 C/T cg11693508 chr17:37793320 STARD3 0.62 7.08 0.36 8.79e-12 Bipolar disorder; CRC cis rs7827545 1.000 rs7008158 chr8:135565982 T/C cg17885191 chr8:135476712 NA 0.54 7.41 0.38 1.06e-12 Hypertension (SNP x SNP interaction); CRC cis rs17854409 0.764 rs8116995 chr20:61475824 A/G cg05147244 chr20:61493195 TCFL5 0.55 5.69 0.3 2.75e-8 Obesity-related traits; CRC cis rs1165205 0.558 rs531750 chr6:25882642 C/G cg12310025 chr6:25882481 NA -0.87 -13.94 -0.61 5.07e-35 Urate levels; CRC cis rs6681460 0.932 rs523132 chr1:67174440 A/G cg02459107 chr1:67143332 SGIP1 -0.37 -6.34 -0.33 7.67e-10 Presence of antiphospholipid antibodies; CRC cis rs7208859 0.673 rs60020217 chr17:29185054 G/A cg13385521 chr17:29058706 SUZ12P 0.69 8.02 0.4 1.81e-14 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC trans rs877282 0.898 rs11253356 chr10:768604 G/A cg22713356 chr15:30763199 NA 1.13 13.93 0.61 5.38e-35 Uric acid levels; CRC cis rs7487075 0.567 rs4768712 chr12:46811521 T/C cg22049899 chr12:47219821 SLC38A4 0.31 5.67 0.3 3.17e-8 Itch intensity from mosquito bite; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg05206762 chr4:8160379 ABLIM2 0.44 6.28 0.33 1.1e-9 Intelligence (multi-trait analysis); CRC cis rs3733585 0.699 rs57574512 chr4:9960182 T/C cg11266682 chr4:10021025 SLC2A9 -0.47 -9.67 -0.47 1.2e-19 Cleft plate (environmental tobacco smoke interaction); CRC cis rs117623576 0.941 rs211424 chr10:32398895 A/G cg03047570 chr10:32398778 NA 0.73 8.14 0.41 8.19e-15 Anti-saccade response; CRC cis rs7811142 0.779 rs28680963 chr7:99905475 C/G cg00814883 chr7:100076585 TSC22D4 -0.65 -7.9 -0.4 4.16e-14 Platelet count; CRC cis rs2404602 0.647 rs12910820 chr15:77022825 T/C cg03037974 chr15:76606532 NA -0.54 -8.18 -0.41 6.47e-15 Blood metabolite levels; CRC cis rs6772849 0.896 rs4557179 chr3:128366726 A/C cg08795948 chr3:128337044 NA 0.36 6.29 0.33 1.02e-9 Monocyte percentage of white cells;Monocyte count; CRC trans rs208520 0.837 rs208498 chr6:66931560 G/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.92 -11.96 -0.55 1.28e-27 Exhaled nitric oxide output; CRC trans rs9956878 0.555 rs8085188 chr18:73544676 A/G cg04362369 chr14:21905501 CHD8 -0.42 -6.73 -0.35 7.52e-11 Obesity-related traits; CRC cis rs2075371 0.932 rs1862052 chr7:133981227 G/A cg20476274 chr7:133979776 SLC35B4 0.73 12.06 0.55 5.76e-28 Mean platelet volume; CRC cis rs8114671 0.527 rs2295352 chr20:33320055 C/G cg24642439 chr20:33292090 TP53INP2 -0.37 -5.67 -0.3 3.21e-8 Height; CRC cis rs7615952 0.558 rs7641353 chr3:125339879 T/C cg11143507 chr3:125485238 NA -0.6 -7.66 -0.39 2.16e-13 Blood pressure (smoking interaction); CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg04297258 chr16:88772664 RNF166;CTU2 -0.5 -6.14 -0.32 2.37e-9 Diisocyanate-induced asthma; CRC cis rs17756712 0.725 rs3757122 chr6:611030 A/G cg16786516 chr6:604617 EXOC2 0.45 5.75 0.3 2.07e-8 Vertical cup-disc ratio; CRC cis rs7107174 1.000 rs2511155 chr11:77969223 G/A cg02023728 chr11:77925099 USP35 0.52 7.99 0.4 2.37e-14 Testicular germ cell tumor; CRC cis rs8141797 0.901 rs5751804 chr22:24490105 A/C cg20894457 chr22:24584366 SUSD2 -0.61 -7.58 -0.39 3.55e-13 Amyotrophic lateral sclerosis;Coronary artery disease; CRC cis rs8044868 0.530 rs2550868 chr16:72066072 G/A cg06172871 chr16:72088244 HP 0.43 6.27 0.33 1.12e-9 Body mass index (change over time) in cancer or chronic obstructive pulmonary disease;Body mass index (change over time) in cancer; CRC cis rs4713118 0.614 rs9468209 chr6:27694421 C/T cg02683197 chr6:28174875 NA 0.55 7.85 0.4 5.82e-14 Parkinson's disease; CRC trans rs17685 0.753 rs1637051 chr7:75730659 G/A cg19862616 chr7:65841803 NCRNA00174 1.0 18.87 0.72 2.33e-54 Coffee consumption;Coffee consumption (cups per day); CRC cis rs57994353 0.897 rs3812594 chr9:139368953 G/A cg14119001 chr9:139324193 INPP5E -0.44 -6.2 -0.32 1.68e-9 Eosinophil counts;Cutaneous squamous cell carcinoma; CRC cis rs6942756 0.955 rs2056694 chr7:128923817 C/T cg02491457 chr7:128862824 NA -0.78 -10.64 -0.51 6.51e-23 White matter hyperintensity burden; CRC trans rs2228479 0.850 rs12596934 chr16:89841605 T/G cg24644049 chr4:85504048 CDS1 0.92 7.68 0.39 1.79e-13 Skin colour saturation; CRC cis rs9303401 1.000 rs9904677 chr17:56873025 A/G cg12560992 chr17:57184187 TRIM37 0.44 5.83 0.31 1.35e-8 Cognitive test performance; CRC trans rs7726839 0.794 rs11739663 chr5:594083 A/G cg25482853 chr8:67687455 SGK3 0.69 8.78 0.44 9.31e-17 Obesity-related traits; CRC cis rs8180040 0.647 rs57756484 chr3:47239333 A/G cg27129171 chr3:47204927 SETD2 -0.72 -11.39 -0.53 1.46e-25 Colorectal cancer; CRC trans rs61931739 0.500 rs10844864 chr12:34532468 A/G cg13010199 chr12:38710504 ALG10B 0.45 6.52 0.34 2.65e-10 Morning vs. evening chronotype; CRC cis rs4285028 0.948 rs73855481 chr3:121676951 C/A cg20356878 chr3:121714668 ILDR1 -0.48 -6.95 -0.36 1.93e-11 Multiple sclerosis; CRC cis rs7773004 0.905 rs994379 chr6:26305407 C/G cg00631329 chr6:26305371 NA 0.41 6.88 0.35 3.05e-11 Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for body mass index;Waist circumference adjusted for BMI in non-smokers;Waist circumference adjusted for BMI (adjusted for smoking behaviour); CRC cis rs4332037 0.722 rs4721140 chr7:1917635 A/T cg25834613 chr7:1915315 MAD1L1 -0.5 -7.87 -0.4 5.27e-14 Bipolar disorder; CRC cis rs13256369 1.000 rs13267501 chr8:8574058 G/A cg17143192 chr8:8559678 CLDN23 0.47 6.22 0.32 1.47e-9 Obesity-related traits; CRC cis rs10540 1.000 rs79808876 chr11:465763 C/A cg03576123 chr11:487126 PTDSS2 -1.0 -10.33 -0.49 7.51e-22 Body mass index; CRC cis rs9916302 0.904 rs55660616 chr17:37684990 C/A cg15445000 chr17:37608096 MED1 0.43 9.45 0.46 6.4e-19 Glomerular filtration rate (creatinine); CRC cis rs7216064 1.000 rs55896768 chr17:65913358 T/C cg12091567 chr17:66097778 LOC651250 -0.63 -7.88 -0.4 4.73e-14 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CRC cis rs1018836 0.632 rs9642910 chr8:91475724 G/T cg16814680 chr8:91681699 NA -0.65 -10.2 -0.49 2.03e-21 Ejection fraction in Tripanosoma cruzi seropositivity; CRC cis rs6951245 0.554 rs11544331 chr7:1131411 C/T cg20603222 chr7:1096387 C7orf50;GPR146 -0.47 -6.02 -0.32 4.57e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs9807989 0.839 rs10192157 chr2:102968356 C/T cg03938978 chr2:103052716 IL18RAP 0.37 5.97 0.31 6.2e-9 Asthma; CRC cis rs1046896 0.594 rs8070403 chr17:80865404 A/G cg08200770 chr17:80723486 TBCD -0.48 -7.37 -0.38 1.41e-12 Glycated hemoglobin levels; CRC cis rs4363385 0.747 rs2225919 chr1:152969603 A/G cg25856811 chr1:152973957 SPRR3 -0.25 -6.8 -0.35 4.98e-11 Inflammatory skin disease; CRC cis rs7811142 1.000 rs11559117 chr7:100076614 A/G cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.16 17.05 0.68 3.64e-47 Platelet count; CRC cis rs7677751 0.806 rs7673853 chr4:55096606 T/C cg13615338 chr4:55094005 PDGFRA 0.4 5.95 0.31 6.86e-9 Corneal astigmatism; CRC cis rs1150668 0.835 rs1233696 chr6:28143010 T/C cg25164649 chr6:28176230 NA 0.47 6.95 0.36 2e-11 Pubertal anthropometrics; CRC cis rs7762018 0.607 rs75999653 chr6:170066927 A/G cg24289452 chr6:170231220 NA -0.81 -7.0 -0.36 1.45e-11 Thiazide-induced adverse metabolic effects in hypertensive patients; CRC cis rs11166629 1.000 rs7003870 chr8:135616586 A/G cg27224718 chr8:135614730 ZFAT 0.54 7.84 0.4 6.28e-14 Smoking quantity; CRC cis rs8028182 0.636 rs11636199 chr15:75825337 A/G cg20655648 chr15:75932815 IMP3 0.44 6.72 0.35 7.81e-11 Sudden cardiac arrest; CRC cis rs10504229 0.728 rs17215621 chr8:58152706 C/A cg22535103 chr8:58192502 C8orf71 -0.68 -8.37 -0.42 1.72e-15 Developmental language disorder (linguistic errors); CRC cis rs253959 0.672 rs4921056 chr5:115422934 A/G cg23108291 chr5:115420582 COMMD10 0.45 6.39 0.33 5.67e-10 Bipolar disorder and schizophrenia; CRC cis rs1552244 1.000 rs113771705 chr3:10075983 T/C cg10729496 chr3:10149963 C3orf24 0.55 7.11 0.37 7.07e-12 Alzheimer's disease; CRC cis rs28386778 0.897 rs1062790 chr17:61896455 A/G cg06873352 chr17:61820015 STRADA 0.77 14.46 0.62 5e-37 Prudent dietary pattern; CRC cis rs6429082 0.689 rs4659923 chr1:235709519 C/T cg26050004 chr1:235667680 B3GALNT2 -0.48 -5.95 -0.31 7.02e-9 Adiposity; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg05445914 chr16:30134068 MAPK3 0.41 6.89 0.36 2.8e-11 Liver disease severity in Alagille syndrome; CRC cis rs7552404 0.727 rs1159214 chr1:76317910 G/T cg10523679 chr1:76189770 ACADM -0.68 -8.98 -0.44 2.09e-17 Blood metabolite levels;Acylcarnitine levels; CRC cis rs3820068 0.603 rs72647118 chr1:15956535 G/T cg27534772 chr1:16042836 PLEKHM2 0.55 10.98 0.52 4.27e-24 Systolic blood pressure; CRC cis rs7072216 0.922 rs942814 chr10:100151305 A/G cg26618903 chr10:100175079 PYROXD2 -0.39 -6.67 -0.35 1.09e-10 Metabolite levels; CRC cis rs2011503 1.000 rs45631651 chr19:19638743 A/G cg11584989 chr19:19387371 SF4 0.58 6.48 0.34 3.27e-10 Bipolar disorder; CRC cis rs2985684 1.000 rs8014170 chr14:50071694 C/G cg10008539 chr14:50087325 RPL36AL;MGAT2 -0.45 -5.9 -0.31 9.14e-9 Carotid intima media thickness; CRC cis rs28386778 0.863 rs2665834 chr17:61904724 T/C cg11494091 chr17:61959527 GH2 0.6 10.14 0.49 3.3e-21 Prudent dietary pattern; CRC cis rs524281 0.861 rs10750778 chr11:65948648 T/C cg14036092 chr11:66035641 RAB1B -0.47 -5.71 -0.3 2.54e-8 Electroencephalogram traits; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg11646757 chr7:128095699 C7orf68 0.46 6.09 0.32 3.1e-9 Thyroid stimulating hormone; CRC cis rs12048904 0.505 rs11166508 chr1:101233511 A/G cg00063077 chr1:101360652 SLC30A7;EXTL2 -0.68 -9.6 -0.47 2.12e-19 Multiple sclerosis; CRC cis rs9916302 0.904 rs11867312 chr17:37597748 C/T cg00129232 chr17:37814104 STARD3 -0.54 -8.1 -0.41 1.06e-14 Glomerular filtration rate (creatinine); CRC cis rs9486719 0.948 rs2472904 chr6:96874962 T/G cg06623918 chr6:96969491 KIAA0776 0.8 9.42 0.46 8.23e-19 Migraine;Coronary artery disease; CRC cis rs9463078 0.809 rs9357469 chr6:45049811 C/T cg25276700 chr6:44698697 NA -0.29 -6.93 -0.36 2.25e-11 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; CRC cis rs9611565 0.625 rs9611606 chr22:41931074 A/G cg03806693 chr22:41940476 POLR3H -1.12 -14.99 -0.64 4.54e-39 Vitiligo; CRC trans rs12706411 0.571 rs35132220 chr7:122171197 A/G cg04149356 chr5:158139306 EBF1 0.68 6.12 0.32 2.67e-9 Alzheimer disease and age of onset; CRC cis rs3106136 0.934 rs34396188 chr4:95191292 A/C cg11021082 chr4:95130006 SMARCAD1 -0.44 -6.44 -0.33 4.2e-10 Capecitabine sensitivity; CRC cis rs908922 0.676 rs549044 chr1:152514332 C/T cg23254163 chr1:152506842 NA 0.43 8.22 0.41 4.88e-15 Hair morphology; CRC trans rs8073060 0.586 rs7208672 chr17:33989759 G/A cg19694781 chr19:47549865 TMEM160 -1.06 -14.7 -0.63 5.66e-38 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; CRC cis rs9322193 0.926 rs9285525 chr6:150122389 C/G cg13206674 chr6:150067644 NUP43 0.57 8.14 0.41 8.29e-15 Lung cancer; CRC cis rs11190604 0.943 rs3750632 chr10:102279295 G/C cg16342193 chr10:102329863 NA -0.35 -5.92 -0.31 8e-9 Palmitoleic acid (16:1n-7) levels; CRC trans rs7615952 0.546 rs11717632 chr3:125321130 G/C cg07211511 chr3:129823064 LOC729375 -0.61 -6.97 -0.36 1.73e-11 Blood pressure (smoking interaction); CRC cis rs10751667 0.580 rs7396041 chr11:1001607 G/A cg23136738 chr11:925521 AP2A2 -0.41 -6.33 -0.33 8e-10 Alzheimer's disease (late onset); CRC cis rs1552244 0.554 rs3846167 chr3:9996426 T/C cg08888203 chr3:10149979 C3orf24 0.47 7.23 0.37 3.47e-12 Alzheimer's disease; CRC cis rs9928842 0.771 rs2870471 chr16:75274282 A/G cg09066997 chr16:75300724 BCAR1 -0.61 -6.52 -0.34 2.6200000000000003e-10 Alcoholic chronic pancreatitis; CRC cis rs243505 0.661 rs887570 chr7:148505255 A/G cg09806900 chr7:148480153 CUL1 0.49 7.08 0.36 9.04e-12 Inflammatory bowel disease;Crohn's disease; CRC cis rs713587 0.520 rs512419 chr2:25310155 G/T cg22495460 chr2:25135724 ADCY3 0.44 6.5 0.34 3.04e-10 Body mass index in non-asthmatics; CRC cis rs1799949 1.000 rs35330014 chr17:41212547 C/T cg23758822 chr17:41437982 NA 0.8 13.58 0.6 1.22e-33 Menopause (age at onset); CRC cis rs10504229 0.953 rs66815941 chr8:58187306 C/T cg05313129 chr8:58192883 C8orf71 -0.47 -6.99 -0.36 1.49e-11 Developmental language disorder (linguistic errors); CRC cis rs11212617 1.000 rs7943165 chr11:108274890 T/C cg12106634 chr11:108092400 ATM;NPAT 0.43 6.52 0.34 2.61e-10 Response to metformin in type 2 diabetes (glycemic); CRC cis rs4629180 1.000 rs11123889 chr2:102107180 G/A cg04415270 chr2:102091202 RFX8 0.59 8.0 0.4 2.17e-14 Chronic rhinosinusitis with nasal polyps; CRC cis rs17152411 0.793 rs12569669 chr10:126592671 A/G cg07906193 chr10:126599966 NA 0.57 6.46 0.34 3.78e-10 Height; CRC cis rs1580019 0.922 rs1466147 chr7:32486262 C/T cg07520158 chr7:32535189 LSM5;AVL9 0.49 6.49 0.34 3.18e-10 Cognitive ability; CRC cis rs4862750 0.872 rs9997374 chr4:187877549 T/A cg07414643 chr4:187882934 NA 0.38 6.73 0.35 7.37e-11 Lobe attachment (rater-scored or self-reported); CRC cis rs7945718 1.000 rs7945719 chr11:12748820 A/C cg25843174 chr11:12811716 TEAD1 0.47 8.97 0.44 2.23e-17 Educational attainment (years of education); CRC cis rs9868809 0.505 rs9882549 chr3:48749358 C/T cg07636037 chr3:49044803 WDR6 -0.7 -6.92 -0.36 2.36e-11 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; CRC cis rs7264396 0.528 rs6058370 chr20:34518592 C/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.59 -9.15 -0.45 6.36e-18 Total cholesterol levels; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg07889337 chr17:38257022 NR1D1 0.4 6.38 0.33 6.14e-10 Liver disease severity in Alagille syndrome; CRC cis rs7197653 0.667 rs16957831 chr16:68378341 C/T cg05110241 chr16:68378359 PRMT7 -0.76 -7.96 -0.4 2.88e-14 Magnesium levels; CRC cis rs35883536 1.000 rs11586051 chr1:101096240 A/T cg14515779 chr1:101123966 NA 0.42 7.95 0.4 3e-14 Monocyte count; CRC cis rs9359856 0.518 rs11965790 chr6:90261621 C/T cg13799429 chr6:90582589 CASP8AP2 -0.59 -6.83 -0.35 4.11e-11 Bipolar disorder; CRC cis rs7113874 0.569 rs11041978 chr11:8578150 T/C cg17679104 chr11:8615758 STK33 -0.35 -5.9 -0.31 8.88e-9 Body mass index in physically active individuals;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs3931020 0.530 rs12125889 chr1:75241971 A/G cg17719053 chr1:75198211 TYW3;CRYZ 0.44 6.02 0.32 4.63e-9 Resistin levels; CRC cis rs8180040 0.932 rs11711265 chr3:47558448 T/C cg27129171 chr3:47204927 SETD2 0.52 8.15 0.41 7.78e-15 Colorectal cancer; CRC cis rs10883723 0.810 rs10883729 chr10:104273943 A/G cg04362960 chr10:104952993 NT5C2 -0.41 -5.68 -0.3 2.96e-8 Allergic disease (asthma, hay fever or eczema); CRC cis rs155076 1.000 rs195570 chr13:21867580 T/G cg21970626 chr13:21893289 NA 0.42 5.72 0.3 2.36e-8 White matter hyperintensity burden; CRC cis rs3845702 1.000 rs3768839 chr2:180835992 G/A cg23417306 chr2:180868811 CWC22 -0.45 -6.09 -0.32 3.1e-9 Schizophrenia; CRC trans rs16924631 0.818 rs10975595 chr9:6452555 G/A cg18105767 chr19:41698548 CYP2S1 -0.47 -6.03 -0.32 4.35e-9 Periodontal microbiota; CRC cis rs8031584 0.706 rs2177670 chr15:31157751 G/T cg08704250 chr15:31115839 NA -0.56 -9.87 -0.48 2.78e-20 Huntington's disease progression; CRC cis rs4689388 0.926 rs4234730 chr4:6296343 A/G cg14416269 chr4:6271139 WFS1 0.42 6.86 0.35 3.36e-11 Type 2 diabetes and other traits;Type 2 diabetes; CRC cis rs4731207 0.596 rs7802007 chr7:124638034 G/A cg23710748 chr7:124431027 NA -0.39 -6.19 -0.32 1.83e-9 Cutaneous malignant melanoma; CRC cis rs11098499 0.863 rs2127823 chr4:120485670 G/T cg24375607 chr4:120327624 NA 0.48 7.24 0.37 3.13e-12 Corneal astigmatism; CRC cis rs7584330 0.666 rs60671275 chr2:238374318 C/A cg16989719 chr2:238392110 NA -0.42 -7.07 -0.36 9.14e-12 Prostate cancer; CRC cis rs9814567 1.000 rs2370642 chr3:134222136 C/T cg06109529 chr3:134205091 CEP63;ANAPC13 -0.81 -12.37 -0.56 4.1e-29 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs4285028 0.948 rs34181646 chr3:121705373 T/A cg20356878 chr3:121714668 ILDR1 -0.49 -7.18 -0.37 4.66e-12 Multiple sclerosis; CRC trans rs2797160 1.000 rs1954361 chr6:126001423 C/G cg05039488 chr6:79577232 IRAK1BP1 -0.49 -7.32 -0.37 1.93e-12 Endometrial cancer; CRC cis rs921968 0.643 rs545460 chr2:219392159 A/G cg02176678 chr2:219576539 TTLL4 0.49 8.04 0.41 1.63e-14 Mean corpuscular hemoglobin concentration; CRC cis rs3806843 0.576 rs246009 chr5:140338069 A/G cg19875535 chr5:140030758 IK -0.41 -6.32 -0.33 8.44e-10 Depressive symptoms (multi-trait analysis); CRC cis rs68170813 0.559 rs78553765 chr7:106930787 C/T cg02696742 chr7:106810147 HBP1 -0.6 -6.65 -0.34 1.25e-10 Coronary artery disease; CRC cis rs11122272 0.735 rs2486740 chr1:231517552 T/C cg06096015 chr1:231504339 EGLN1 0.4 5.94 0.31 7.17e-9 Hemoglobin concentration; CRC trans rs3780486 0.505 rs10758188 chr9:33123386 C/T cg04842962 chr6:43655489 MRPS18A -0.95 -17.37 -0.69 1.95e-48 IgG glycosylation; CRC cis rs6831352 0.918 rs29001232 chr4:100046654 G/C cg12011299 chr4:100065546 ADH4 -0.49 -9.27 -0.45 2.61e-18 Alcohol dependence; CRC cis rs4319547 0.695 rs1973463 chr12:122938003 A/G cg23029597 chr12:123009494 RSRC2 -0.47 -5.87 -0.31 1.05e-8 Body mass index; CRC cis rs2070997 0.617 rs7848941 chr9:133744672 G/A cg01000188 chr9:133769184 QRFP 0.53 7.21 0.37 3.75e-12 Response to amphetamines; CRC cis rs35264875 0.851 rs72930611 chr11:68863659 G/T cg01993067 chr11:68851601 TPCN2 0.57 6.59 0.34 1.77e-10 Blond vs. brown hair color; CRC cis rs453301 0.686 rs11785634 chr8:8892597 G/T cg06636001 chr8:8085503 FLJ10661 -0.48 -7.25 -0.37 3.09e-12 Joint mobility (Beighton score); CRC cis rs7474896 0.507 rs2474555 chr10:38465220 G/C cg25427524 chr10:38739819 LOC399744 -0.53 -5.9 -0.31 9.26e-9 Obesity (extreme); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg19403496 chr1:101491408 DPH5 0.39 6.57 0.34 1.93e-10 Liver disease severity in Alagille syndrome; CRC cis rs1843834 0.505 rs7585047 chr2:225373897 C/T cg22455342 chr2:225449267 CUL3 0.66 8.84 0.44 5.96e-17 IgE levels in asthmatics (D.p. specific); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg07898764 chr7:101847052 CUX1 0.4 6.03 0.32 4.48e-9 Liver disease severity in Alagille syndrome; CRC cis rs1865760 0.865 rs1541987 chr6:25950397 A/G cg17691542 chr6:26056736 HIST1H1C -0.54 -8.17 -0.41 6.53e-15 Height; CRC cis rs9309711 0.689 rs4535075 chr2:3481716 T/C cg15506890 chr2:3487001 NA -0.54 -8.68 -0.43 1.88e-16 Neurofibrillary tangles; CRC cis rs6860806 0.507 rs169256 chr5:131688533 A/G cg16647868 chr5:131706066 SLC22A5 0.46 6.08 0.32 3.35e-9 Breast cancer; CRC cis rs17711722 0.701 rs781145 chr7:65440370 A/C cg00343986 chr7:65444356 GUSB 0.57 8.55 0.43 4.79e-16 Calcium levels; CRC cis rs6089584 1.000 rs6089591 chr20:60570548 A/C cg23262073 chr20:60523788 NA -0.42 -7.08 -0.36 8.51e-12 Body mass index; CRC cis rs11648796 0.757 rs6600231 chr16:766485 A/G cg27144592 chr16:783916 NARFL -0.56 -9.25 -0.45 2.97e-18 Height; CRC cis rs7119 0.651 rs12902948 chr15:77849254 T/C cg10437265 chr15:77819839 NA 0.59 9.95 0.48 1.46e-20 Type 2 diabetes; CRC trans rs11098499 0.866 rs12374352 chr4:120281977 C/T cg25214090 chr10:38739885 LOC399744 0.61 9.66 0.47 1.39e-19 Corneal astigmatism; CRC trans rs34421088 0.560 rs1478898 chr8:11395079 G/A cg06636001 chr8:8085503 FLJ10661 -0.54 -8.09 -0.41 1.16e-14 Neuroticism; CRC cis rs834811 0.602 rs4732183 chr7:135888513 G/T cg01726295 chr7:135938950 NA 0.36 6.1 0.32 2.97e-9 Post-traumatic stress disorder; CRC cis rs3204270 0.639 rs11867543 chr17:79655046 C/T cg18367735 chr17:79674897 NA 0.5 5.74 0.3 2.18e-8 Dental caries; CRC cis rs7312933 0.531 rs1796380 chr12:42791543 T/G cg11827402 chr12:42719852 PPHLN1;ZCRB1 -0.67 -9.85 -0.48 3.04e-20 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CRC cis rs597539 0.652 rs513359 chr11:68669496 A/T cg21963583 chr11:68658836 MRPL21 -0.62 -11.35 -0.53 2.08e-25 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs10870270 1.000 rs10870292 chr10:133770782 G/C cg08754478 chr10:133766260 PPP2R2D -0.67 -9.31 -0.46 1.84e-18 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; CRC cis rs8060686 0.516 rs255052 chr16:68024995 C/T cg08314208 chr16:67682810 RLTPR -0.59 -6.48 -0.34 3.31e-10 HDL cholesterol;Metabolic syndrome; CRC cis rs9322817 0.691 rs2499664 chr6:105301484 C/G cg02098413 chr6:105308735 HACE1 0.43 8.54 0.43 5.18e-16 Thyroid stimulating hormone; CRC cis rs4332037 0.539 rs56305291 chr7:2048706 A/G cg25834613 chr7:1915315 MAD1L1 -0.46 -6.42 -0.33 4.64e-10 Bipolar disorder; CRC cis rs12760731 0.565 rs6701832 chr1:178156775 A/G cg00404053 chr1:178313656 RASAL2 1.02 10.74 0.51 2.85e-23 Obesity-related traits; CRC cis rs875971 0.767 rs12668005 chr7:65909021 T/C cg11764359 chr7:65958608 NA 0.57 8.29 0.42 2.95e-15 Aortic root size; CRC cis rs728616 0.558 rs34268041 chr10:82148639 A/G cg05935833 chr10:81318306 SFTPA2 -0.58 -7.06 -0.36 9.74e-12 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs4604732 0.631 rs11490199 chr1:247625737 A/G cg02104434 chr1:247694406 LOC148824;OR2C3 0.6 8.82 0.44 6.67e-17 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CRC cis rs6546324 0.959 rs2861694 chr2:67845739 A/G cg15745817 chr2:67799979 NA -0.29 -5.69 -0.3 2.76e-8 Endometriosis; CRC cis rs77106637 0.932 rs17244499 chr11:72629946 C/T cg03713592 chr11:72463424 ARAP1 -0.75 -7.27 -0.37 2.58e-12 Type 2 diabetes; CRC cis rs3617 0.625 rs6769789 chr3:52874446 C/T cg15147215 chr3:52552868 STAB1 0.53 9.24 0.45 3.04e-18 Red blood cell count;Autism spectrum disorder or schizophrenia; CRC trans rs7819412 0.594 rs7460507 chr8:10969075 C/T cg16141378 chr3:129829833 LOC729375 0.43 6.13 0.32 2.53e-9 Triglycerides; CRC cis rs6570726 0.818 rs399516 chr6:145810849 C/A cg23711669 chr6:146136114 FBXO30 0.66 11.6 0.54 2.57e-26 Lobe attachment (rater-scored or self-reported); CRC trans rs747782 0.585 rs1604655 chr11:48274778 G/A cg15704280 chr7:45808275 SEPT13 0.67 6.64 0.34 1.3100000000000001e-10 Intraocular pressure; CRC cis rs9649213 0.574 rs60077733 chr7:97970137 C/T cg21770322 chr7:97807741 LMTK2 0.53 8.62 0.43 2.94e-16 Prostate cancer (SNP x SNP interaction); CRC cis rs2075371 0.966 rs1901204 chr7:133985896 A/G cg11752832 chr7:134001865 SLC35B4 0.5 7.85 0.4 5.78e-14 Mean platelet volume; CRC cis rs9309473 0.950 rs1052162 chr2:73829372 A/G cg20560298 chr2:73613845 ALMS1 0.46 5.79 0.3 1.64e-8 Metabolite levels; CRC trans rs3780486 0.846 rs7865745 chr9:33140976 A/G cg20290983 chr6:43655470 MRPS18A -1.18 -26.8 -0.83 9.76e-85 IgG glycosylation; CRC cis rs2404602 0.692 rs4886503 chr15:77108874 C/T cg03037974 chr15:76606532 NA -0.65 -11.12 -0.52 1.37e-24 Blood metabolite levels; CRC cis rs10504229 0.679 rs75402323 chr8:58136227 A/G cg04204079 chr8:58130323 NA -0.45 -5.78 -0.3 1.71e-8 Developmental language disorder (linguistic errors); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg20877313 chr12:56881753 GLS2 0.42 6.39 0.33 5.79e-10 Intelligence (multi-trait analysis); CRC cis rs77861329 0.748 rs9851576 chr3:52091254 C/T cg08692210 chr3:52188851 WDR51A -0.53 -6.41 -0.33 5.09e-10 Macrophage inflammatory protein 1b levels; CRC cis rs780096 0.526 rs2010087 chr2:27637235 C/T cg12648201 chr2:27665141 KRTCAP3 -0.31 -6.04 -0.32 4.25e-9 Total body bone mineral density; CRC cis rs2298450 0.654 rs9984891 chr21:37626379 A/G cg02919814 chr21:37666008 DOPEY2 -0.5 -6.58 -0.34 1.84e-10 Schizophrenia; CRC cis rs7043114 0.525 rs7045409 chr9:95201540 A/T cg13798575 chr9:95087839 CENPP;NOL8 -0.4 -5.86 -0.31 1.11e-8 Height; CRC cis rs425277 0.583 rs12059660 chr1:2041461 C/T cg04315214 chr1:2043799 PRKCZ 0.47 8.55 0.43 4.69e-16 Height; CRC cis rs919433 0.963 rs12693815 chr2:198168403 T/C cg20885578 chr2:198174922 NA -0.43 -6.95 -0.36 2.03e-11 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC cis rs7945705 0.846 rs2742540 chr11:8899528 A/G cg21881798 chr11:8931708 C11orf17;ST5 0.65 10.59 0.5 9.86e-23 Hemoglobin concentration; CRC cis rs9560113 0.960 rs953260 chr13:112173685 C/T cg10483660 chr13:112241077 NA 0.35 5.61 0.3 4.35e-8 Menarche (age at onset); CRC cis rs798554 0.704 rs798531 chr7:2770067 G/C cg19717773 chr7:2847554 GNA12 -0.39 -6.32 -0.33 8.45e-10 Height; CRC cis rs3749237 0.615 rs6792911 chr3:49429856 C/T cg03060546 chr3:49711283 APEH 0.68 11.79 0.55 5.13e-27 Resting heart rate; CRC cis rs1552244 0.572 rs6797536 chr3:10168802 C/T cg18598329 chr3:10140678 FANCD2;C3orf24 0.88 10.51 0.5 1.75e-22 Alzheimer's disease; CRC cis rs2204008 0.658 rs11181310 chr12:38315963 C/A cg26384229 chr12:38710491 ALG10B 0.68 9.55 0.47 3.05e-19 Bladder cancer; CRC cis rs2180341 0.960 rs9398839 chr6:127665863 G/A cg24812749 chr6:127587940 RNF146 0.97 13.58 0.6 1.14e-33 Breast cancer; CRC cis rs17092148 1.000 rs6058112 chr20:33322006 G/C cg08999081 chr20:33150536 PIGU 0.46 5.77 0.3 1.8e-8 Neuroticism; CRC cis rs10861342 1.000 rs12320123 chr12:105492167 C/T cg23923672 chr12:105501055 KIAA1033 0.61 5.76 0.3 1.98e-8 IgG glycosylation; CRC cis rs2230307 0.536 rs834278 chr1:100510882 T/C cg24955406 chr1:100503596 HIAT1 0.61 7.32 0.37 1.88e-12 Carotid intima media thickness; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg00959118 chr1:169455055 SLC19A2 0.4 6.08 0.32 3.27e-9 Liver disease severity in Alagille syndrome; CRC cis rs28386778 0.897 rs2584601 chr17:61940977 T/C cg23090583 chr17:61904693 PSMC5;FTSJ3 1.04 20.31 0.75 5.05e-60 Prudent dietary pattern; CRC cis rs736408 0.509 rs2590838 chr3:52622086 G/A cg11645453 chr3:52864694 ITIH4 0.35 6.46 0.34 3.85e-10 Bipolar disorder; CRC cis rs7191439 0.789 rs4598894 chr16:88776141 G/A cg27087555 chr16:88793112 FAM38A -1.45 -11.79 -0.54 5.49e-27 Plateletcrit; CRC cis rs4713118 0.824 rs13211701 chr6:27750079 T/C cg15786705 chr6:28176104 NA 0.54 7.06 0.36 1.01e-11 Parkinson's disease; CRC cis rs2797160 0.651 rs6569436 chr6:126032104 A/G cg05901451 chr6:126070800 HEY2 0.53 8.58 0.43 3.78e-16 Endometrial cancer; CRC cis rs875971 0.798 rs6460304 chr7:65964728 G/A cg18876405 chr7:65276391 NA 0.5 8.29 0.42 2.85e-15 Aortic root size; CRC cis rs6496667 0.738 rs16944500 chr15:91026973 A/T cg04176472 chr15:90893244 GABARAPL3 -0.51 -7.61 -0.39 2.9e-13 Rheumatoid arthritis; CRC cis rs4363385 0.747 rs1611760 chr1:152957573 T/C cg25856811 chr1:152973957 SPRR3 -0.27 -7.45 -0.38 8.07e-13 Inflammatory skin disease; CRC cis rs9903692 0.954 rs3744346 chr17:46198876 G/C cg21215337 chr17:46176117 CBX1 -0.43 -7.95 -0.4 3.09e-14 Pulse pressure; CRC cis rs10504229 0.683 rs56058640 chr8:58128862 C/T cg21724239 chr8:58056113 NA 0.49 6.81 0.35 4.75e-11 Developmental language disorder (linguistic errors); CRC cis rs10504229 0.953 rs75585481 chr8:58192202 T/C cg24829409 chr8:58192753 C8orf71 -0.68 -11.34 -0.53 2.27e-25 Developmental language disorder (linguistic errors); CRC cis rs7666738 0.830 rs62318504 chr4:98935558 T/G cg17366294 chr4:99064904 C4orf37 0.43 7.32 0.37 1.95e-12 Colonoscopy-negative controls vs population controls; CRC cis rs7552404 0.883 rs7513363 chr1:76143443 A/G cg22875332 chr1:76189707 ACADM 0.76 11.06 0.52 2.23e-24 Blood metabolite levels;Acylcarnitine levels; CRC cis rs929354 0.651 rs6951298 chr7:156949149 T/C cg16102536 chr7:156981717 UBE3C 0.4 6.69 0.35 9.57e-11 Body mass index; CRC cis rs2243480 1.000 rs10807701 chr7:65724686 C/A cg12463550 chr7:65579703 CRCP -0.68 -6.14 -0.32 2.33e-9 Diabetic kidney disease; CRC cis rs9322193 0.923 rs12205092 chr6:150082511 G/T cg07701084 chr6:150067640 NUP43 0.56 7.72 0.39 1.42e-13 Lung cancer; CRC cis rs2153535 0.601 rs9406160 chr6:8464907 A/C cg07606381 chr6:8435919 SLC35B3 0.67 10.82 0.51 1.51e-23 Motion sickness; CRC cis rs896854 0.596 rs7823059 chr8:95974961 T/C cg23172400 chr8:95962367 TP53INP1 -0.49 -8.19 -0.41 5.96e-15 Type 2 diabetes; CRC cis rs9916302 0.904 rs11078910 chr17:37671269 G/T cg00129232 chr17:37814104 STARD3 -0.55 -8.21 -0.41 5.1e-15 Glomerular filtration rate (creatinine); CRC cis rs10751667 0.643 rs10751666 chr11:941933 C/T ch.11.42038R chr11:967971 AP2A2 0.58 9.85 0.48 3.1e-20 Alzheimer's disease (late onset); CRC cis rs6545883 1.000 rs6545883 chr2:61772257 A/G cg15711740 chr2:61764176 XPO1 -0.49 -6.74 -0.35 7.01e-11 Tuberculosis; CRC cis rs12142240 0.698 rs6697123 chr1:46811310 A/C cg14993813 chr1:46806288 NSUN4 -0.51 -6.48 -0.34 3.28e-10 Menopause (age at onset); CRC cis rs941408 1.000 rs1640271 chr19:2799979 C/T cg06609049 chr19:2785107 THOP1 0.66 10.3 0.49 9.34e-22 Total cholesterol levels; CRC cis rs877282 0.898 rs11253352 chr10:766598 C/A cg17470449 chr10:769945 NA 0.64 8.34 0.42 2.01e-15 Uric acid levels; CRC cis rs1046896 0.553 rs3744160 chr17:80828303 G/A cg03160526 chr17:80928410 B3GNTL1 0.57 7.77 0.39 1.02e-13 Glycated hemoglobin levels; CRC cis rs3749237 1.000 rs11920900 chr3:49823024 G/C cg05072774 chr3:49840536 C3orf54 -0.44 -5.71 -0.3 2.55e-8 Resting heart rate; CRC cis rs208520 0.837 rs208486 chr6:66926255 A/T cg07460842 chr6:66804631 NA -0.96 -12.4 -0.56 3.23e-29 Exhaled nitric oxide output; CRC cis rs4689592 0.587 rs3822269 chr4:7069901 T/C cg19539972 chr4:7069911 GRPEL1 0.83 10.68 0.51 4.72e-23 Monocyte percentage of white cells; CRC cis rs2762353 0.779 rs6905614 chr6:25840485 G/T cg03517284 chr6:25882590 NA -0.45 -6.71 -0.35 8.58e-11 Blood metabolite levels; CRC cis rs2243480 1.000 rs451396 chr7:65484074 T/A cg18252515 chr7:66147081 NA -1.1 -12.3 -0.56 7.15e-29 Diabetic kidney disease; CRC cis rs28655083 0.636 rs7194836 chr16:77066830 A/G cg01753188 chr16:77233325 SYCE1L;MON1B -0.56 -6.64 -0.34 1.28e-10 Lobe attachment (rater-scored or self-reported); CRC cis rs734999 0.588 rs4648652 chr1:2535758 A/G cg18854424 chr1:2615690 NA 0.49 9.81 0.48 4.4e-20 Ulcerative colitis; CRC trans rs1814175 0.645 rs1721995 chr11:49915488 A/G cg21153622 chr11:89784906 NA -0.39 -6.08 -0.32 3.33e-9 Height; CRC cis rs2180341 0.532 rs6933893 chr6:127707250 A/G cg24812749 chr6:127587940 RNF146 0.65 9.63 0.47 1.69e-19 Breast cancer; CRC cis rs9583531 0.600 rs6492303 chr13:111356800 G/A cg24331049 chr13:111365604 ING1 0.57 7.88 0.4 4.78e-14 Coronary artery disease; CRC trans rs7615952 0.605 rs11708269 chr3:125332150 C/T cg02560186 chr11:3602584 NA -0.71 -7.15 -0.37 5.68e-12 Blood pressure (smoking interaction); CRC cis rs7605827 0.836 rs13009246 chr2:15640237 A/G cg19274914 chr2:15703543 NA 0.4 6.15 0.32 2.27e-9 Educational attainment (years of education); CRC cis rs11122272 0.735 rs2808602 chr1:231537303 A/G cg06096015 chr1:231504339 EGLN1 0.41 6.11 0.32 2.88e-9 Hemoglobin concentration; CRC cis rs644799 0.625 rs1255175 chr11:95471186 G/A cg25622487 chr11:95524042 FAM76B;CEP57 0.44 6.33 0.33 8.22e-10 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs17401966 0.931 rs2185252 chr1:10415912 T/C cg19773385 chr1:10388646 KIF1B -0.68 -11.03 -0.52 2.77e-24 Hepatocellular carcinoma; CRC cis rs2836974 0.897 rs35391055 chr21:40525516 G/A cg06238570 chr21:40685208 BRWD1 0.71 10.1 0.49 4.5e-21 Cognitive function; CRC cis rs13256369 0.774 rs11777719 chr8:8581038 A/G cg18904891 chr8:8559673 CLDN23 0.48 6.6 0.34 1.63e-10 Obesity-related traits; CRC cis rs7119 0.717 rs16968835 chr15:77734261 G/A cg05673287 chr15:77411982 SGK269 -0.52 -8.07 -0.41 1.36e-14 Type 2 diabetes; CRC trans rs916888 0.773 rs199445 chr17:44817408 C/T cg22968622 chr17:43663579 NA 1.4 18.86 0.72 2.63e-54 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs1348850 0.914 rs8941 chr2:178406481 C/T cg27490568 chr2:178487706 NA 0.39 5.81 0.31 1.46e-8 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs6570726 0.846 rs870491 chr6:145933390 T/G cg13319975 chr6:146136371 FBXO30 -0.44 -6.53 -0.34 2.44e-10 Lobe attachment (rater-scored or self-reported); CRC cis rs25422 0.938 rs62424176 chr6:118798602 T/C cg22561889 chr6:118971681 C6orf204 0.51 6.55 0.34 2.25e-10 Renal cell carcinoma; CRC cis rs875971 0.660 rs79009421 chr7:66068509 G/C cg11764359 chr7:65958608 NA -0.55 -8.5 -0.42 6.69e-16 Aortic root size; CRC cis rs62229266 0.804 rs62230821 chr21:37425116 C/T cg12218747 chr21:37451666 NA -0.45 -7.75 -0.39 1.18e-13 Mitral valve prolapse; CRC cis rs4604732 0.631 rs74154673 chr1:247625629 G/A cg12758973 chr1:247694275 LOC148824;OR2C3 0.42 6.14 0.32 2.32e-9 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CRC cis rs9583531 0.527 rs3818496 chr13:111358488 G/A cg24331049 chr13:111365604 ING1 0.55 7.69 0.39 1.74e-13 Coronary artery disease; CRC cis rs13064411 0.696 rs6768979 chr3:113204149 G/A cg18753928 chr3:113234510 CCDC52 -0.7 -10.83 -0.51 1.45e-23 Response to simvastatin treatment (PCSK9 protein level change); CRC trans rs1728785 1.000 rs1094282 chr16:68577260 G/A cg04657470 chr2:198365150 HSPE1;HSPD1 0.58 7.0 0.36 1.46e-11 Ulcerative colitis; CRC cis rs3018066 0.666 rs6816614 chr4:107049750 C/G cg01869342 chr4:106983673 TBCK 0.44 5.8 0.3 1.57e-8 Cancer; CRC cis rs9303401 0.659 rs34913878 chr17:56897094 A/G cg10487724 chr17:56770010 TEX14;RAD51C 0.76 9.59 0.47 2.2e-19 Cognitive test performance; CRC cis rs7618915 0.501 rs3733041 chr3:52731598 T/C cg11645453 chr3:52864694 ITIH4 0.36 6.5 0.34 3.01e-10 Bipolar disorder; CRC cis rs1799949 0.930 rs66499067 chr17:41248484 G/C cg01879757 chr17:41196368 BRCA1 -0.41 -6.02 -0.32 4.61e-9 Menopause (age at onset); CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg02895995 chr19:7554069 PEX11G 0.46 5.97 0.31 6.14e-9 Thyroid stimulating hormone; CRC cis rs10463316 0.963 rs10463315 chr5:150745615 T/A cg03212797 chr5:150827313 SLC36A1 -0.43 -6.35 -0.33 7.16e-10 Metabolite levels (Pyroglutamine); CRC cis rs561341 0.629 rs7216107 chr17:30224419 G/A cg00745463 chr17:30367425 LRRC37B -0.46 -6.38 -0.33 5.95e-10 Hip circumference adjusted for BMI; CRC cis rs4604732 0.631 rs12039596 chr1:247624766 A/G cg02104434 chr1:247694406 LOC148824;OR2C3 0.6 8.91 0.44 3.53e-17 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CRC cis rs17376456 0.569 rs10476520 chr5:93058290 A/C cg09848695 chr5:92956644 FAM172A;MIR2277 0.52 5.91 0.31 8.35e-9 Diabetic retinopathy; CRC cis rs2411233 0.967 rs7180968 chr15:39288527 C/G cg23129342 chr15:39283510 NA 0.32 6.03 0.32 4.51e-9 Platelet count; CRC cis rs9399137 0.507 rs12664898 chr6:135288663 T/C cg22676075 chr6:135203613 NA 0.59 8.79 0.44 8.4e-17 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; CRC cis rs7772486 0.754 rs2328709 chr6:146106819 A/G cg05347473 chr6:146136440 FBXO30 -0.4 -5.98 -0.31 5.68e-9 Lobe attachment (rater-scored or self-reported); CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg08051231 chr16:19422492 TMC5 0.46 6.94 0.36 2.03e-11 Thyroid stimulating hormone; CRC cis rs713477 1.000 rs7148481 chr14:55909267 G/A cg13175173 chr14:55914753 NA -0.52 -9.8 -0.48 4.49e-20 Pediatric bone mineral content (femoral neck); CRC cis rs28386778 0.897 rs2854208 chr17:61946885 C/T cg06873352 chr17:61820015 STRADA 0.76 14.17 0.62 6.69e-36 Prudent dietary pattern; CRC cis rs611744 0.647 rs674391 chr8:109242803 A/T cg21045802 chr8:109455806 TTC35 0.39 6.39 0.33 5.56e-10 Dupuytren's disease; CRC cis rs11190604 1.000 rs11190597 chr10:102293676 A/T cg07080220 chr10:102295463 HIF1AN 0.47 5.68 0.3 3.03e-8 Palmitoleic acid (16:1n-7) levels; CRC cis rs8141529 0.732 rs5762784 chr22:29171298 C/T cg15103426 chr22:29168792 CCDC117 0.6 8.87 0.44 4.75e-17 Lymphocyte counts; CRC cis rs6546550 0.743 rs6546548 chr2:70017022 A/G cg02498382 chr2:70120550 SNRNP27 -0.42 -6.86 -0.35 3.4e-11 Prevalent atrial fibrillation; CRC cis rs7618915 0.571 rs1961959 chr3:52585760 G/C cg18099408 chr3:52552593 STAB1 -0.45 -7.4 -0.38 1.16e-12 Bipolar disorder; CRC cis rs977987 0.843 rs11149820 chr16:75422760 G/A cg03315344 chr16:75512273 CHST6 0.52 8.82 0.44 7.03e-17 Dupuytren's disease; CRC cis rs7086627 0.515 rs10887899 chr10:82210214 G/A cg09626299 chr10:82213104 TSPAN14 -0.37 -6.12 -0.32 2.6e-9 Post bronchodilator FEV1; CRC cis rs3741404 0.609 rs666497 chr11:63869821 G/C cg18225595 chr11:63971243 STIP1 0.41 6.61 0.34 1.55e-10 Platelet count; CRC cis rs7809950 0.954 rs2520241 chr7:107135443 A/G cg23024343 chr7:107201750 COG5 -0.62 -9.01 -0.44 1.68e-17 Coronary artery disease; CRC cis rs6495122 0.699 rs3784789 chr15:75082552 C/G cg14664628 chr15:75095509 CSK -0.69 -11.3 -0.53 3.17e-25 Caffeine consumption;Diastolic blood pressure;Coffee consumption; CRC cis rs4718428 1.000 rs4718428 chr7:66421446 T/G cg18252515 chr7:66147081 NA -0.48 -6.74 -0.35 7.03e-11 Corneal structure; CRC cis rs6964587 0.967 rs12531966 chr7:91765840 A/G cg17063962 chr7:91808500 NA 0.78 12.26 0.56 1e-28 Breast cancer; CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg17548431 chr4:160024475 NA 0.37 6.17 0.32 1.97e-9 Obesity-related traits; CRC cis rs2457480 0.516 rs2035416 chr10:44649690 T/C cg09554077 chr10:44749378 NA 0.46 5.89 0.31 9.39e-9 Coronary artery disease; CRC cis rs919433 0.619 rs699318 chr2:198281743 T/C cg10820045 chr2:198174542 NA 0.38 6.31 0.33 9.24e-10 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC cis rs780096 0.506 rs2288155 chr2:27714526 T/C cg21248554 chr2:27665150 KRTCAP3 -0.33 -7.3 -0.37 2.24e-12 Total body bone mineral density; CRC cis rs1178968 1.000 rs13240408 chr7:72758023 T/C cg25889504 chr7:72793014 NA 0.53 5.93 0.31 7.73e-9 Triglyceride levels; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg01261044 chr14:35451962 SRP54 0.5 7.15 0.37 5.65e-12 Response to antipsychotic treatment; CRC cis rs28386778 0.897 rs2854214 chr17:61945449 C/G cg11494091 chr17:61959527 GH2 -0.62 -10.5 -0.5 1.99e-22 Prudent dietary pattern; CRC cis rs16852403 0.583 rs10494510 chr1:178074581 A/G cg00404053 chr1:178313656 RASAL2 0.58 7.28 0.37 2.45e-12 Childhood ear infection; CRC cis rs11030122 0.661 rs10835561 chr11:4087594 C/T cg18678763 chr11:4115507 RRM1 -0.5 -7.96 -0.4 2.79e-14 Mean platelet volume;Platelet distribution width; CRC cis rs7089973 0.872 rs7923295 chr10:116625159 C/G cg03647239 chr10:116582469 FAM160B1 -0.41 -5.71 -0.3 2.54e-8 Bipolar disorder or attention deficit hyperactivity disorder; CRC cis rs7552404 1.000 rs7518038 chr1:76154430 G/A cg10523679 chr1:76189770 ACADM 0.83 11.53 0.54 4.61e-26 Blood metabolite levels;Acylcarnitine levels; CRC cis rs1218582 0.710 rs4845687 chr1:154878911 A/G cg24250549 chr1:154909240 PMVK 0.65 11.29 0.53 3.2e-25 Prostate cancer; CRC cis rs13108904 0.935 rs4974575 chr4:1252028 A/G cg20887711 chr4:1340912 KIAA1530 0.42 6.0 0.31 5.35e-9 Obesity-related traits; CRC cis rs12980942 0.591 rs11879435 chr19:41757603 C/T cg25627403 chr19:41769009 HNRNPUL1 0.57 6.62 0.34 1.46e-10 Coronary artery disease; CRC cis rs9837602 1.000 rs7610486 chr3:99732564 A/G cg07805332 chr3:99536008 MIR548G;C3orf26 -0.49 -6.34 -0.33 7.59e-10 Breast cancer; CRC cis rs28374715 0.662 rs691907 chr15:41474657 C/G cg18705301 chr15:41695430 NDUFAF1 0.85 13.08 0.58 9.14e-32 Ulcerative colitis; CRC cis rs7937682 0.889 rs487985 chr11:111517908 G/A cg09085632 chr11:111637200 PPP2R1B -0.99 -19.28 -0.73 5.84e-56 Primary sclerosing cholangitis; CRC cis rs9457247 0.663 rs7749278 chr6:167435325 C/T cg07741184 chr6:167504864 NA -0.36 -6.39 -0.33 5.77e-10 Crohn's disease; CRC cis rs13392177 0.684 rs11695527 chr2:219068103 A/G cg00012203 chr2:219082015 ARPC2 0.48 7.04 0.36 1.1e-11 Pyoderma gangrenosum in inflammatory bowel disease; CRC cis rs6502050 0.731 rs76421195 chr17:80109326 T/C cg19223190 chr17:80058835 NA 0.4 6.36 0.33 6.88e-10 Life satisfaction; CRC cis rs6585424 1.000 rs12779955 chr10:81940864 C/T cg11900509 chr10:81946545 ANXA11 0.76 9.35 0.46 1.43e-18 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs897984 0.721 rs4889525 chr16:30989858 T/C cg00531865 chr16:30841666 NA 0.47 6.78 0.35 5.6e-11 Dementia with Lewy bodies; CRC cis rs73206853 0.925 rs12318836 chr12:110642190 A/C cg12870014 chr12:110450643 ANKRD13A 0.67 8.88 0.44 4.47e-17 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC cis rs1862618 0.713 rs832549 chr5:56183542 C/T cg03609598 chr5:56110824 MAP3K1 -0.85 -10.06 -0.49 6.18e-21 Initial pursuit acceleration; CRC cis rs4713118 0.621 rs10484403 chr6:28033523 A/G cg12273811 chr6:28175739 NA 0.64 8.12 0.41 9.7e-15 Parkinson's disease; CRC cis rs9487051 0.872 rs1111863 chr6:109611206 C/T cg21918786 chr6:109611834 NA 0.47 8.48 0.42 7.64e-16 Reticulocyte fraction of red cells; CRC cis rs10883723 0.810 rs2296588 chr10:104248087 T/C cg22532475 chr10:104410764 TRIM8 -0.37 -6.85 -0.35 3.57e-11 Allergic disease (asthma, hay fever or eczema); CRC cis rs4713118 0.662 rs9468277 chr6:28028390 C/A cg18032046 chr6:28092343 ZSCAN16 -0.5 -6.33 -0.33 7.89e-10 Parkinson's disease; CRC cis rs10751667 0.643 rs7396767 chr11:938808 G/A cg23136738 chr11:925521 AP2A2 -0.41 -6.73 -0.35 7.76e-11 Alzheimer's disease (late onset); CRC cis rs11148252 0.538 rs2897976 chr13:52715944 G/A cg02158880 chr13:53174818 NA 0.39 5.64 0.3 3.74e-8 Lewy body disease; CRC cis rs9914988 0.943 rs7215000 chr17:27088436 C/T cg07195577 chr17:27052828 TLCD1 0.42 6.05 0.32 4.01e-9 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs9814567 0.896 rs6790338 chr3:134208167 G/C cg06109529 chr3:134205091 CEP63;ANAPC13 -0.82 -12.34 -0.56 5.16e-29 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs6691722 0.506 rs12030365 chr1:24739220 T/A cg02336364 chr1:24764700 NIPAL3 0.46 8.16 0.41 6.97e-15 Response to interferon beta in multiple sclerosis; CRC cis rs6502050 0.835 rs4641801 chr17:80154021 G/A cg09264619 chr17:80180166 NA -0.35 -5.95 -0.31 6.9e-9 Life satisfaction; CRC cis rs6938 0.534 rs12913293 chr15:75184458 G/C cg18612461 chr15:75251733 NA 0.38 5.96 0.31 6.56e-9 Breast cancer; CRC cis rs9911578 1.000 rs302854 chr17:56683612 G/A cg12560992 chr17:57184187 TRIM37 0.9 16.58 0.67 2.73e-45 Intelligence (multi-trait analysis); CRC cis rs7677751 0.767 rs890204 chr4:55064439 C/G cg17187183 chr4:55093834 PDGFRA 0.49 7.02 0.36 1.3e-11 Corneal astigmatism; CRC trans rs4276421 0.806 rs12520124 chr5:45435019 T/C cg04793272 chr11:119020941 ABCG4 -0.38 -6.23 -0.32 1.46e-9 P wave duration; CRC cis rs10504229 0.683 rs6984765 chr8:58127124 T/C cg21724239 chr8:58056113 NA 0.49 6.81 0.35 4.75e-11 Developmental language disorder (linguistic errors); CRC cis rs875971 0.660 rs7807944 chr7:66087195 C/G cg00343986 chr7:65444356 GUSB -0.51 -7.61 -0.39 2.88e-13 Aortic root size; CRC cis rs6500395 0.962 rs9938126 chr16:48572121 A/T cg04672837 chr16:48644449 N4BP1 0.42 6.03 0.32 4.4e-9 Response to tocilizumab in rheumatoid arthritis; CRC cis rs34375054 0.672 rs58416336 chr12:125606428 G/T cg06287003 chr12:125626642 AACS -0.46 -7.18 -0.37 4.64e-12 Post bronchodilator FEV1/FVC ratio; CRC cis rs4888262 0.526 rs7205258 chr16:74642539 C/T cg01733217 chr16:74700730 RFWD3 0.79 12.05 0.55 5.92e-28 Testicular germ cell tumor; CRC cis rs9911578 0.967 rs7503190 chr17:57184162 A/C cg12560992 chr17:57184187 TRIM37 0.95 18.2 0.71 1.07e-51 Intelligence (multi-trait analysis); CRC cis rs34172651 0.874 rs200534 chr16:24752641 G/A cg06028605 chr16:24865363 SLC5A11 -0.46 -8.46 -0.42 8.68e-16 Intelligence (multi-trait analysis); CRC cis rs7618915 0.501 rs7624716 chr3:52751534 T/C cg05573699 chr3:52720067 GNL3;PBRM1 -0.48 -6.95 -0.36 2.01e-11 Bipolar disorder; CRC cis rs1403694 0.515 rs710448 chr3:186452885 A/G cg04611788 chr3:186434169 KNG1 -0.58 -8.36 -0.42 1.79e-15 Blood protein levels; CRC cis rs870825 0.860 rs11132253 chr4:185595472 C/T cg04058563 chr4:185651563 MLF1IP 0.57 5.95 0.31 6.94e-9 Blood protein levels; CRC cis rs2290159 0.747 rs6777175 chr3:12646255 A/T cg23032965 chr3:12705835 RAF1 0.46 6.22 0.32 1.49e-9 Cholesterol, total; CRC cis rs8031584 0.678 rs3122 chr15:31170290 A/T cg14829155 chr15:31115871 NA 0.64 10.0 0.48 9.57e-21 Huntington's disease progression; CRC trans rs9747201 1.000 rs56051385 chr17:80126712 T/C cg07393940 chr7:158741817 NA -0.51 -7.35 -0.38 1.61e-12 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs7258465 1.000 rs8107367 chr19:18564705 A/G cg06953865 chr19:18549723 ISYNA1 -0.37 -5.66 -0.3 3.38e-8 Breast cancer; CRC cis rs7552404 0.765 rs1251078 chr1:76189488 C/G cg03433033 chr1:76189801 ACADM -0.93 -17.23 -0.69 7.15e-48 Blood metabolite levels;Acylcarnitine levels; CRC cis rs7264396 0.580 rs2425173 chr20:34445142 G/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.57 -8.39 -0.42 1.48e-15 Total cholesterol levels; CRC cis rs1552244 0.882 rs66559400 chr3:10012551 G/A cg02579736 chr3:10068473 FANCD2;CIDECP 0.93 12.04 0.55 6.82e-28 Alzheimer's disease; CRC cis rs11608355 0.508 rs12817730 chr12:109799330 G/A cg19025524 chr12:109796872 NA -0.48 -7.15 -0.37 5.77e-12 Neuroticism; CRC cis rs394563 0.967 rs438852 chr6:149794533 C/T cg11245181 chr6:149772854 ZC3H12D 0.52 8.99 0.44 1.99e-17 Dupuytren's disease; CRC cis rs9522267 0.535 rs7326875 chr13:112236231 C/T cg14352298 chr13:112236639 NA 0.29 6.74 0.35 7.32e-11 Hepatitis; CRC cis rs2842992 0.830 rs2273819 chr6:160183325 G/C cg19482086 chr6:160211437 TCP1;MRPL18 0.72 9.42 0.46 8.34e-19 Age-related macular degeneration (geographic atrophy); CRC cis rs2976388 0.566 rs6998746 chr8:143802456 A/C cg20041105 chr8:143859282 LYNX1 0.43 7.04 0.36 1.13e-11 Urinary tract infection frequency; CRC cis rs10504229 1.000 rs58947041 chr8:58188934 G/A cg05313129 chr8:58192883 C8orf71 -0.46 -6.93 -0.36 2.25e-11 Developmental language disorder (linguistic errors); CRC cis rs6844506 1.000 rs4862356 chr4:185220262 A/G cg06915193 chr4:185205329 NA 0.41 5.74 0.3 2.13e-8 Gestational age at birth in premature rupture of membrane-initiated deliveries (child effect); CRC cis rs35146811 0.622 rs6946204 chr7:99589125 T/C cg03265037 chr7:99691720 MIR25;MCM7;MIR106B;MIR93 0.43 5.76 0.3 1.92e-8 Coronary artery disease; CRC cis rs7312933 1.000 rs11181308 chr12:42445259 A/G cg11827402 chr12:42719852 PPHLN1;ZCRB1 0.6 7.63 0.39 2.57e-13 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CRC cis rs5771242 0.518 rs7290465 chr22:50679758 C/T cg16473166 chr22:50639996 SELO -0.47 -5.86 -0.31 1.15e-8 Lung function (forced expiratory flow during mid-portion (25% and 75%) of forced vital capacity); CRC trans rs7976838 0.908 rs35203350 chr12:60143404 A/G cg16974014 chr22:22007515 MIR130B 0.49 6.0 0.31 5.21e-9 Response to zileuton treatment in asthma (FEV1 change interaction); CRC trans rs17685 0.753 rs1639617 chr7:75701728 A/G cg19862616 chr7:65841803 NCRNA00174 1.0 18.87 0.72 2.33e-54 Coffee consumption;Coffee consumption (cups per day); CRC cis rs72848980 0.512 rs56033495 chr10:105383611 G/A cg00126946 chr10:105363258 SH3PXD2A 0.52 6.48 0.34 3.43e-10 White matter hyperintensity burden; CRC cis rs117623576 0.941 rs11008775 chr10:32410307 T/C cg03047570 chr10:32398778 NA -0.76 -8.78 -0.44 8.91e-17 Anti-saccade response; CRC cis rs1670533 0.932 rs2248083 chr4:1052166 A/C cg27284194 chr4:1044797 NA 0.51 6.16 0.32 2.11e-9 Recombination rate (females); CRC cis rs12594515 0.967 rs8039088 chr15:45990178 T/C cg01629716 chr15:45996671 NA 0.41 8.46 0.42 9.03e-16 Waist circumference;Weight; CRC cis rs853679 0.546 rs200996 chr6:27811828 G/A cg06470822 chr6:28175283 NA 0.67 5.79 0.3 1.66e-8 Depression; CRC cis rs909674 0.541 rs5757655 chr22:39797178 C/G cg05872129 chr22:39784769 NA 0.63 12.61 0.57 5.15e-30 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; CRC cis rs6500602 0.627 rs841231 chr16:4583147 C/T cg06139259 chr16:4526053 HMOX2;NMRAL1 -0.47 -6.38 -0.33 6.09e-10 Schizophrenia; CRC cis rs7618915 0.571 rs7623199 chr3:52605974 C/T cg18404041 chr3:52824283 ITIH1 -0.43 -8.97 -0.44 2.23e-17 Bipolar disorder; CRC cis rs7572644 0.621 rs4462754 chr2:28063994 C/T cg27432699 chr2:27873401 GPN1 0.46 6.23 0.32 1.43e-9 Response to carboplatin and paclitaxel in ovarian cancer (Caspase 3/7 EC50); CRC cis rs7927771 0.864 rs2868459 chr11:47454972 C/G cg20307385 chr11:47447363 PSMC3 -0.62 -9.07 -0.45 1.09e-17 Subjective well-being; CRC cis rs6838801 0.892 rs12647024 chr4:77575503 T/C cg17476223 chr4:77663285 SHROOM3 0.42 5.92 0.31 8.27e-9 Cleft lip with or without cleft palate; CRC cis rs4481887 0.927 rs28524655 chr1:248474331 C/T cg00666640 chr1:248458726 OR2T12 0.45 7.8 0.4 8.31e-14 Common traits (Other); CRC cis rs12048904 0.505 rs11166508 chr1:101233511 A/G cg15686842 chr1:101360669 SLC30A7;EXTL2 -0.55 -7.28 -0.37 2.44e-12 Multiple sclerosis; CRC cis rs7833790 0.963 rs2400473 chr8:82703403 C/T cg27398817 chr8:82754497 SNX16 -0.51 -6.09 -0.32 3.15e-9 Diastolic blood pressure; CRC cis rs1150668 0.745 rs213238 chr6:28321993 T/C cg21251018 chr6:28226885 NKAPL 0.56 9.56 0.47 2.8e-19 Pubertal anthropometrics; CRC cis rs208520 0.690 rs12194057 chr6:66745616 A/G cg07460842 chr6:66804631 NA 1.06 14.78 0.63 2.91e-38 Exhaled nitric oxide output; CRC cis rs9894429 0.646 rs7406825 chr17:79619188 C/T cg21984481 chr17:79567631 NPLOC4 -0.4 -6.66 -0.34 1.15e-10 Eye color traits; CRC cis rs883565 0.655 rs7649923 chr3:39102137 G/A cg01426195 chr3:39028469 NA -0.54 -8.77 -0.44 9.85e-17 Handedness; CRC cis rs11785400 1.000 rs4557682 chr8:143738182 T/C cg24634471 chr8:143751801 JRK 0.52 7.43 0.38 9.67e-13 Schizophrenia; CRC cis rs17023223 0.537 rs12081585 chr1:119615956 A/C cg05756136 chr1:119680316 WARS2 -0.54 -7.13 -0.37 6.21e-12 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for BMI in active individuals; CRC cis rs3008870 1.000 rs11208976 chr1:67434411 A/G cg08660285 chr1:67390436 MIER1;WDR78 -1.03 -15.27 -0.64 3.45e-40 Lymphocyte percentage of white cells; CRC cis rs2204008 0.775 rs11514369 chr12:38305411 C/T cg13010199 chr12:38710504 ALG10B 0.46 6.25 0.33 1.3e-9 Bladder cancer; CRC cis rs1799949 0.965 rs11654051 chr17:41419656 C/T cg19454999 chr17:41278357 BRCA1;NBR2 0.53 8.06 0.41 1.47e-14 Menopause (age at onset); CRC cis rs6952808 0.531 rs3779003 chr7:2184902 C/T cg04267008 chr7:1944627 MAD1L1 -0.58 -7.99 -0.4 2.23e-14 Bipolar disorder and schizophrenia; CRC cis rs7493 1.000 rs3779492 chr7:95044183 C/T cg01874867 chr7:94954059 PON1 -0.48 -6.19 -0.32 1.81e-9 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs651907 0.514 rs55654108 chr3:101425703 A/G cg11279151 chr3:101281821 RG9MTD1 -0.54 -7.53 -0.38 5.03e-13 Colorectal cancer; CRC cis rs8060686 0.858 rs7191129 chr16:67801391 A/G cg26727032 chr16:67993705 SLC12A4 -0.71 -11.1 -0.52 1.6e-24 HDL cholesterol;Metabolic syndrome; CRC cis rs10242455 0.702 rs6974831 chr7:99131605 A/G cg18809830 chr7:99032528 PTCD1 -1.19 -8.64 -0.43 2.53e-16 Blood metabolite levels; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg08472398 chr6:26156741 HIST1H1E 0.38 6.23 0.32 1.42e-9 Liver disease severity in Alagille syndrome; CRC cis rs9902453 0.874 rs7220004 chr17:28369548 G/T cg26525008 chr17:28256777 EFCAB5;SSH2 -0.69 -11.35 -0.53 2.01e-25 Coffee consumption (cups per day); CRC cis rs6831352 0.918 rs6813415 chr4:100048509 T/C cg13256891 chr4:100009986 ADH5 -0.66 -8.89 -0.44 4.04e-17 Alcohol dependence; CRC cis rs7666738 0.830 rs35213297 chr4:98984049 T/C cg05340658 chr4:99064831 C4orf37 0.58 8.82 0.44 6.61e-17 Colonoscopy-negative controls vs population controls; CRC cis rs6502050 0.777 rs6502058 chr17:80082500 A/C cg09264619 chr17:80180166 NA 0.36 6.08 0.32 3.4e-9 Life satisfaction; CRC cis rs28386778 0.897 rs7221853 chr17:61859836 A/G cg25654072 chr17:61904446 PSMC5;FTSJ3 0.74 11.57 0.54 3.39e-26 Prudent dietary pattern; CRC cis rs6502050 0.835 rs12938965 chr17:80128646 G/A cg22110888 chr17:80059540 CCDC57 0.4 6.43 0.33 4.37e-10 Life satisfaction; CRC cis rs2635047 0.682 rs9960932 chr18:44792445 C/T cg19077165 chr18:44547161 KATNAL2 -0.39 -5.96 -0.31 6.58e-9 Educational attainment; CRC cis rs2933343 0.621 rs789242 chr3:128585707 T/C cg11901034 chr3:128598214 ACAD9 -0.55 -8.07 -0.41 1.36e-14 IgG glycosylation; CRC cis rs524281 0.861 rs10791855 chr11:65963737 A/G cg16950941 chr11:66035639 RAB1B -0.61 -7.53 -0.38 5.06e-13 Electroencephalogram traits; CRC cis rs7274811 0.711 rs293713 chr20:31942247 A/G cg03904042 chr20:32255491 NECAB3;C20orf134 0.41 5.86 0.31 1.11e-8 Height; CRC cis rs73206853 0.841 rs56306150 chr12:110716775 A/T cg12870014 chr12:110450643 ANKRD13A 0.8 7.72 0.39 1.39e-13 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC cis rs7584330 0.744 rs58223447 chr2:238378644 G/C cg14458575 chr2:238380390 NA 0.89 16.18 0.67 9.83e-44 Prostate cancer; CRC trans rs6777098 0.793 rs4546146 chr3:166951314 C/T cg07098314 chr17:39823360 NA 0.54 6.08 0.32 3.33e-9 Response to paliperidone in schizophrenia (positive Marder score); CRC cis rs2019137 0.560 rs6707386 chr2:113981022 G/A cg21610815 chr2:113994035 PAX8;LOC654433;LOC440839 0.59 8.68 0.43 1.83e-16 Lymphocyte counts; CRC cis rs1005277 0.579 rs2021649 chr10:38392122 C/T cg25427524 chr10:38739819 LOC399744 -0.77 -13.69 -0.6 4.65e-34 Extrinsic epigenetic age acceleration; CRC cis rs185694 0.948 rs200512 chr13:30906446 C/T cg07600127 chr13:30881527 KATNAL1 -0.56 -6.03 -0.32 4.39e-9 Antineutrophil cytoplasmic antibody-associated vasculitis; CRC cis rs4727027 0.901 rs12671341 chr7:148805282 T/C cg23583168 chr7:148888333 NA -0.85 -13.67 -0.6 5.3e-34 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC cis rs6952808 1.000 rs4601204 chr7:1890925 C/T cg22963979 chr7:1858916 MAD1L1 -0.66 -10.09 -0.49 4.87e-21 Bipolar disorder and schizophrenia; CRC cis rs9463078 0.665 rs9472339 chr6:44711791 A/G cg25276700 chr6:44698697 NA 0.32 8.07 0.41 1.31e-14 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; CRC cis rs11645898 0.745 rs72787062 chr16:72105844 G/A cg14768367 chr16:72042858 DHODH -0.68 -7.01 -0.36 1.35e-11 Blood protein levels; CRC cis rs7412746 0.658 rs59988025 chr1:150940358 C/T cg15448220 chr1:150897856 SETDB1 0.55 8.02 0.4 1.89e-14 Melanoma; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg20273774 chr5:180671298 GNB2L1;SNORD95 0.49 6.5 0.34 3e-10 Thyroid stimulating hormone; CRC cis rs17376456 0.825 rs10079708 chr5:93261796 G/C cg09848695 chr5:92956644 FAM172A;MIR2277 0.68 6.03 0.32 4.45e-9 Diabetic retinopathy; CRC cis rs6604026 0.656 rs11164845 chr1:93416685 A/G cg17283838 chr1:93427260 FAM69A 0.42 5.65 0.3 3.43e-8 Multiple sclerosis; CRC cis rs4481887 0.927 rs12744455 chr1:248479960 A/G cg13385794 chr1:248469461 NA 0.4 7.09 0.36 8.35e-12 Common traits (Other); CRC cis rs67478160 0.634 rs7141928 chr14:104219949 C/T cg08213375 chr14:104286397 PPP1R13B 0.58 11.91 0.55 1.88e-27 Schizophrenia; CRC cis rs17345786 0.667 rs7622940 chr3:101133155 T/C cg12386194 chr3:101231763 SENP7 0.47 6.3 0.33 9.71e-10 Colonoscopy-negative controls vs population controls; CRC cis rs13392177 0.684 rs6720105 chr2:219080718 G/A cg04731861 chr2:219085781 ARPC2 0.34 6.8 0.35 5e-11 Pyoderma gangrenosum in inflammatory bowel disease; CRC cis rs875971 0.756 rs4718328 chr7:65693337 A/G cg18876405 chr7:65276391 NA -0.52 -8.69 -0.43 1.8e-16 Aortic root size; CRC cis rs1552244 0.554 rs13081079 chr3:10056348 A/G cg18598329 chr3:10140678 FANCD2;C3orf24 -0.53 -7.51 -0.38 5.61e-13 Alzheimer's disease; CRC cis rs10131894 0.611 rs175000 chr14:75436367 T/C cg08847533 chr14:75593920 NEK9 -0.68 -10.79 -0.51 1.94e-23 Coronary artery disease; CRC cis rs919433 0.680 rs2124317 chr2:198477606 G/A cg10820045 chr2:198174542 NA 0.42 7.34 0.38 1.71e-12 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC trans rs10982213 0.830 rs2274163 chr9:117188714 C/T cg14051306 chr5:56248243 MIER3 0.4 6.22 0.32 1.55e-9 Interleukin-6 levels; CRC cis rs798554 0.797 rs1182183 chr7:2873136 C/T cg14895029 chr7:2775587 GNA12 -0.43 -6.28 -0.33 1.05e-9 Height; CRC cis rs9649465 0.561 rs600081 chr7:123414591 A/T cg03229431 chr7:123269106 ASB15 0.58 9.39 0.46 1.01e-18 Migraine; CRC cis rs8072100 0.967 rs4793842 chr17:45671506 G/A cg25173405 chr17:45401733 C17orf57 0.42 6.51 0.34 2.84e-10 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs524281 0.773 rs10896105 chr11:66002260 A/G cg14036092 chr11:66035641 RAB1B -0.56 -6.35 -0.33 7.22e-10 Electroencephalogram traits; CRC cis rs881375 0.967 rs1860823 chr9:123659304 T/C cg14255062 chr9:123606675 PSMD5;LOC253039 0.42 6.06 0.32 3.63e-9 Rheumatoid arthritis; CRC cis rs4665809 1.000 rs17040322 chr2:26351274 G/C cg26119090 chr2:26468346 HADHA;HADHB -0.61 -7.88 -0.4 4.97e-14 Gut microbiome composition (summer); CRC cis rs2032447 0.714 rs199739 chr6:25960509 A/C cg18357526 chr6:26021779 HIST1H4A 0.73 10.85 0.51 1.19e-23 Intelligence (multi-trait analysis); CRC trans rs66887589 0.837 rs6534135 chr4:120406302 A/G cg25214090 chr10:38739885 LOC399744 0.41 6.44 0.33 4.26e-10 Diastolic blood pressure; CRC cis rs9398803 0.835 rs4897182 chr6:126755642 A/C cg19875578 chr6:126661172 C6orf173 0.41 5.92 0.31 8.17e-9 Male-pattern baldness; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg01446983 chr17:47754976 SPOP 0.47 6.2 0.32 1.71e-9 Anxiety disorder; CRC cis rs425277 0.583 rs1467217 chr1:2045165 G/A cg04315214 chr1:2043799 PRKCZ 0.47 8.54 0.43 5.11e-16 Height; CRC cis rs3858526 0.959 rs61876224 chr11:5952859 G/A cg13902645 chr11:5959945 NA -0.64 -8.87 -0.44 4.72e-17 DNA methylation (variation); CRC cis rs10089 1.000 rs10478803 chr5:127488855 T/C cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.71 9.95 0.48 1.5e-20 Ileal carcinoids; CRC cis rs172166 0.516 rs2622322 chr6:28117443 C/G cg12273811 chr6:28175739 NA 0.46 6.94 0.36 2.04e-11 Cardiac Troponin-T levels; CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg15235185 chr1:193028809 TROVE2;UCHL5 -0.52 -6.27 -0.33 1.16e-9 Diisocyanate-induced asthma; CRC cis rs17443541 0.507 rs6435020 chr2:200448356 C/T cg03741458 chr2:200468445 NA -0.39 -6.04 -0.32 4.21e-9 Intelligence (multi-trait analysis); CRC cis rs4727027 0.801 rs12666337 chr7:148796253 C/T cg23583168 chr7:148888333 NA -0.89 -14.84 -0.63 1.65e-38 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC cis rs9818758 0.607 rs34566463 chr3:49245077 T/C cg00383909 chr3:49044727 WDR6 1.09 11.1 0.52 1.52e-24 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; CRC cis rs7659604 0.540 rs10007956 chr4:122700669 A/T cg19748678 chr4:122722346 EXOSC9 -0.44 -5.92 -0.31 8.27e-9 Type 2 diabetes; CRC cis rs523522 0.962 rs12371550 chr12:120987643 C/T cg27279351 chr12:120934652 DYNLL1 0.77 11.31 0.53 2.78e-25 High light scatter reticulocyte count; CRC trans rs8073060 0.586 rs225264 chr17:33961335 A/G cg19694781 chr19:47549865 TMEM160 -1.05 -14.7 -0.63 5.76e-38 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; CRC cis rs2635047 0.967 rs3816125 chr18:44601611 C/T cg19077165 chr18:44547161 KATNAL2 0.46 6.99 0.36 1.56e-11 Educational attainment; CRC cis rs8072100 1.000 rs11650372 chr17:45721795 G/A cg08085267 chr17:45401833 C17orf57 -0.65 -10.62 -0.51 7.48e-23 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs1008375 0.966 rs4698636 chr4:17632834 T/C cg16339924 chr4:17578868 LAP3 0.56 7.46 0.38 7.66e-13 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs7512552 0.839 rs1097070 chr1:150332955 A/T cg15654264 chr1:150340011 RPRD2 0.59 8.59 0.43 3.42e-16 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg27098574 chr16:75285489 BCAR1 0.41 6.68 0.35 1.01e-10 Obesity-related traits; CRC cis rs9457247 0.663 rs2301436 chr6:167437988 C/T cg07741184 chr6:167504864 NA 0.36 6.3 0.33 9.45e-10 Crohn's disease; CRC cis rs3018066 0.748 rs7657962 chr4:106966715 G/A cg01869342 chr4:106983673 TBCK 0.45 6.59 0.34 1.79e-10 Cancer; CRC trans rs6545883 0.965 rs6718887 chr2:61727215 G/A cg11704114 chr12:21509398 SLCO1A2 -0.32 -6.23 -0.32 1.39e-9 Tuberculosis; CRC cis rs62458065 0.568 rs62466415 chr7:32518254 C/T cg20159608 chr7:32802032 NA -0.6 -7.13 -0.37 6.46e-12 Metabolite levels (HVA/MHPG ratio); CRC cis rs8180040 0.726 rs1869871 chr3:47023948 C/T cg02527881 chr3:46936655 PTH1R -0.42 -7.82 -0.4 7.04e-14 Colorectal cancer; CRC cis rs3540 0.554 rs12900987 chr15:91071776 T/C cg22089800 chr15:90895588 ZNF774 -0.59 -9.65 -0.47 1.4e-19 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; CRC cis rs6860806 0.507 rs200837 chr5:131699958 G/A cg18301423 chr5:131593218 PDLIM4 0.38 6.31 0.33 8.97e-10 Breast cancer; CRC cis rs2976388 0.590 rs7828042 chr8:143819383 A/G cg12516270 chr8:143859308 LYNX1 -0.39 -6.44 -0.33 4.18e-10 Urinary tract infection frequency; CRC cis rs875971 0.798 rs12698522 chr7:65967341 T/C cg11764359 chr7:65958608 NA 0.58 8.67 0.43 1.96e-16 Aortic root size; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg08021986 chr19:12777501 MORG1;MAN2B1 0.43 6.14 0.32 2.31e-9 Response to antipsychotic treatment; CRC cis rs12476592 0.602 rs10469944 chr2:63816672 C/G cg10828910 chr2:63850056 LOC388955 0.49 6.06 0.32 3.75e-9 Childhood ear infection; CRC cis rs11098499 0.754 rs1980027 chr4:120251577 C/T cg24375607 chr4:120327624 NA 0.48 7.74 0.39 1.2e-13 Corneal astigmatism; CRC trans rs12599106 0.629 rs1391904 chr16:34548934 C/T cg11235426 chr6:292522 DUSP22 -0.55 -7.8 -0.4 8.05e-14 Menopause (age at onset); CRC trans rs4263408 0.934 rs9683743 chr4:39703194 A/C cg14951734 chr2:208576279 CCNYL1 -0.41 -6.04 -0.32 4.18e-9 Plasma amyloid beta peptide concentrations (ABx-40); CRC cis rs7727544 0.669 rs113823725 chr5:131563501 C/G cg18758796 chr5:131593413 PDLIM4 0.35 6.27 0.33 1.16e-9 Blood metabolite levels; CRC cis rs6582630 0.598 rs11182207 chr12:38477514 T/C cg26384229 chr12:38710491 ALG10B -0.52 -7.62 -0.39 2.78e-13 Drug-induced liver injury (flucloxacillin); CRC cis rs7727544 0.904 rs58835386 chr5:131600559 A/G cg12564285 chr5:131593104 PDLIM4 0.37 7.24 0.37 3.12e-12 Blood metabolite levels; CRC cis rs9368481 0.761 rs9379952 chr6:26987900 A/T cg05192639 chr6:26864778 GUSBL1 -0.35 -6.05 -0.32 3.97e-9 Autism spectrum disorder or schizophrenia; CRC cis rs6686643 0.762 rs61800372 chr1:165611981 T/C cg19407955 chr1:165599744 MGST3 -0.52 -6.62 -0.34 1.49e-10 Total ventricular volume; CRC cis rs1577917 0.798 rs7772384 chr6:86639680 G/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.53 -6.61 -0.34 1.53e-10 Response to antipsychotic treatment; CRC cis rs7107174 0.892 rs4944196 chr11:78008731 G/A cg02023728 chr11:77925099 USP35 0.52 7.45 0.38 8.29e-13 Testicular germ cell tumor; CRC cis rs8180040 0.903 rs2276853 chr3:47282303 G/A cg10298567 chr3:47292165 KIF9 -0.41 -6.77 -0.35 5.84e-11 Colorectal cancer; CRC cis rs1448094 0.547 rs7954472 chr12:86166258 T/C cg02569458 chr12:86230093 RASSF9 0.46 7.43 0.38 9.61e-13 Major depressive disorder; CRC trans rs6951245 0.572 rs11559183 chr7:1037025 C/A cg13565492 chr6:43139072 SRF -0.86 -6.3 -0.33 9.75e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs61996546 0.622 rs61998698 chr15:26868306 G/C cg15066197 chr15:26874202 GABRB3 -0.44 -6.69 -0.35 9.44e-11 Response to methotrexate in juvenile idiopathic arthritis; CRC cis rs3764400 0.567 rs2325804 chr17:46218545 G/A cg10706073 chr17:46328419 SKAP1 0.59 6.36 0.33 6.7e-10 Body mass index; CRC cis rs7584330 0.554 rs6760913 chr2:238400702 C/T cg14458575 chr2:238380390 NA 0.81 10.53 0.5 1.56e-22 Prostate cancer; CRC cis rs7607369 0.719 rs690882 chr2:219640620 T/C cg02176678 chr2:219576539 TTLL4 -0.46 -7.18 -0.37 4.55e-12 Red blood cell count;Amyotrophic lateral sclerosis; CRC cis rs787274 0.619 rs58643876 chr9:115627285 C/A cg13803584 chr9:115635662 SNX30 -0.66 -6.67 -0.35 1.09e-10 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs1670533 1.000 rs4690212 chr4:1054898 T/C cg27284194 chr4:1044797 NA 0.5 6.2 0.32 1.66e-9 Recombination rate (females); CRC cis rs1552244 0.572 rs3894323 chr3:10168967 G/A cg10729496 chr3:10149963 C3orf24 0.48 5.63 0.3 3.81e-8 Alzheimer's disease; CRC cis rs172166 0.694 rs1150666 chr6:28123928 T/C cg25164649 chr6:28176230 NA 0.64 9.01 0.45 1.66e-17 Cardiac Troponin-T levels; CRC cis rs2019137 0.868 rs6755639 chr2:113981810 A/G cg07594247 chr2:113993304 PAX8;LOC440839;LOC654433 0.38 5.68 0.3 2.92e-8 Lymphocyte counts; CRC trans rs7944735 0.507 rs7396592 chr11:48100837 T/C cg15704280 chr7:45808275 SEPT13 -0.65 -8.29 -0.42 2.85e-15 Intraocular pressure; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg25942691 chr19:36705733 ZNF565;ZNF146 0.43 6.05 0.32 4.04e-9 Response to antipsychotic treatment; CRC cis rs17253792 0.545 rs12893676 chr14:56016159 G/A cg01858014 chr14:56050164 KTN1 -0.89 -6.86 -0.35 3.42e-11 Putamen volume; CRC cis rs28386778 0.897 rs2584624 chr17:61904546 A/G cg23090583 chr17:61904693 PSMC5;FTSJ3 1.05 20.72 0.75 1.28e-61 Prudent dietary pattern; CRC cis rs561341 1.000 rs498391 chr17:30328704 G/A cg23018236 chr17:30244563 NA -0.67 -8.04 -0.41 1.69e-14 Hip circumference adjusted for BMI; CRC cis rs7762018 1.000 rs73242927 chr6:170129573 T/A cg17545662 chr6:170176663 C6orf70 0.56 6.45 0.34 3.94e-10 Thiazide-induced adverse metabolic effects in hypertensive patients; CRC cis rs67311347 1.000 rs11707278 chr3:40487075 A/T cg24209194 chr3:40518798 ZNF619 0.42 6.09 0.32 3.17e-9 Renal cell carcinoma; CRC cis rs3824867 0.920 rs3740685 chr11:47468791 C/T cg05585544 chr11:47624801 NA -0.43 -6.8 -0.35 4.98e-11 Mean corpuscular hemoglobin; CRC cis rs524281 0.773 rs10750781 chr11:66037270 A/G cg16950941 chr11:66035639 RAB1B -0.72 -8.1 -0.41 1.09e-14 Electroencephalogram traits; CRC cis rs116095464 0.614 rs10061564 chr5:271329 T/C cg22496380 chr5:211416 CCDC127 -0.9 -10.29 -0.49 1.07e-21 Breast cancer; CRC cis rs875971 0.964 rs6978721 chr7:65883204 A/G cg18876405 chr7:65276391 NA 0.52 9.04 0.45 1.37e-17 Aortic root size; CRC cis rs644799 0.526 rs542509 chr11:95641602 A/G cg03916912 chr11:95522834 CEP57;FAM76B 0.64 10.43 0.5 3.54e-22 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs6445967 1.000 rs7622074 chr3:58312297 A/G cg23715586 chr3:58305044 RPP14 0.36 6.0 0.31 5.12e-9 Platelet count; CRC cis rs863345 0.604 rs2873594 chr1:158504790 T/C cg12129480 chr1:158549410 OR10X1 -0.3 -6.27 -0.33 1.12e-9 Pneumococcal bacteremia; CRC cis rs9486719 1.000 rs11152959 chr6:96900272 C/T cg06623918 chr6:96969491 KIAA0776 -0.81 -9.47 -0.46 5.55e-19 Migraine;Coronary artery disease; CRC cis rs6831352 0.819 rs2851274 chr4:100025866 G/C cg12011299 chr4:100065546 ADH4 0.49 10.24 0.49 1.5e-21 Alcohol dependence; CRC cis rs737008 1.000 rs737008 chr16:11374866 G/T cg00044050 chr16:11439710 C16orf75 -0.51 -6.79 -0.35 5.15e-11 Obesity-related traits; CRC cis rs1185460 1.000 rs1614264 chr11:118942638 A/C cg23280166 chr11:118938394 VPS11 0.4 6.03 0.32 4.41e-9 Coronary artery disease; CRC trans rs17685 0.884 rs8565 chr7:75630274 T/C cg19862616 chr7:65841803 NCRNA00174 -0.81 -11.57 -0.54 3.36e-26 Coffee consumption;Coffee consumption (cups per day); CRC cis rs7680126 0.632 rs6834645 chr4:10150174 G/A cg00071950 chr4:10020882 SLC2A9 -0.48 -6.18 -0.32 1.91e-9 Urate levels in lean individuals;Urate levels in overweight individuals;Urate levels in obese individuals; CRC cis rs11229555 0.645 rs7945992 chr11:58187755 T/A cg15696309 chr11:58395628 NA -0.82 -10.31 -0.49 8.59e-22 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; CRC cis rs11098499 0.955 rs1511018 chr4:120161580 G/T cg24375607 chr4:120327624 NA 0.47 7.27 0.37 2.58e-12 Corneal astigmatism; CRC cis rs9389248 0.708 rs7750574 chr6:135350932 G/C cg24558204 chr6:135376177 HBS1L 0.62 9.38 0.46 1.1e-18 High light scatter reticulocyte percentage of red cells; CRC cis rs4819052 0.800 rs4819045 chr21:46660138 C/A cg02159808 chr21:46707872 POFUT2;LOC642852 0.49 6.41 0.33 5.19e-10 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs6504622 0.537 rs7342957 chr17:44997356 G/A cg16759221 chr17:45003025 GOSR2 0.6 9.66 0.47 1.33e-19 Orofacial clefts; CRC cis rs875971 1.000 rs6961717 chr7:65587537 C/T cg11764359 chr7:65958608 NA -0.59 -9.45 -0.46 6.53e-19 Aortic root size; CRC cis rs67311347 1.000 rs897117 chr3:40437294 C/T cg09455208 chr3:40491958 NA -0.44 -8.92 -0.44 3.33e-17 Renal cell carcinoma; CRC cis rs7113874 0.543 rs7935708 chr11:8478545 C/A cg17679104 chr11:8615758 STK33 -0.34 -5.71 -0.3 2.51e-8 Body mass index in physically active individuals;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs9894429 1.000 rs4074916 chr17:79579248 G/A cg21028142 chr17:79581711 NPLOC4 -0.4 -8.72 -0.43 1.36e-16 Eye color traits; CRC cis rs6088580 0.634 rs6059892 chr20:33105766 A/G cg08999081 chr20:33150536 PIGU 0.63 11.63 0.54 1.96e-26 Glomerular filtration rate (creatinine); CRC cis rs9322193 0.923 rs4870509 chr6:150023348 C/G cg04369109 chr6:150039330 LATS1 -0.42 -5.65 -0.3 3.52e-8 Lung cancer; CRC cis rs10450586 0.932 rs11029915 chr11:27311468 G/A cg10370305 chr11:27303972 NA 0.35 5.7 0.3 2.68e-8 Total body bone mineral density; CRC cis rs10504229 0.728 rs17216187 chr8:58158778 G/T cg02290350 chr8:58132656 NA -0.51 -6.39 -0.33 5.68e-10 Developmental language disorder (linguistic errors); CRC cis rs4588572 0.643 rs10474555 chr5:77799193 A/G cg11547950 chr5:77652471 NA 0.53 7.45 0.38 8.03e-13 Triglycerides; CRC cis rs6662572 0.737 rs4660333 chr1:46462059 T/C cg08644498 chr1:46502608 NA -0.46 -7.38 -0.38 1.3e-12 Blood protein levels; CRC cis rs1552244 1.000 rs55882090 chr3:10139082 C/T cg13047869 chr3:10149882 C3orf24 0.51 7.34 0.37 1.72e-12 Alzheimer's disease; CRC cis rs172166 0.694 rs2791332 chr6:28108788 C/T cg25164649 chr6:28176230 NA 0.63 9.05 0.45 1.28e-17 Cardiac Troponin-T levels; CRC cis rs8141529 0.732 rs5762815 chr22:29205076 A/G cg15103426 chr22:29168792 CCDC117 0.59 8.67 0.43 2.07e-16 Lymphocyte counts; CRC cis rs6582630 0.555 rs11503799 chr12:38294578 G/A cg13010199 chr12:38710504 ALG10B -0.4 -5.66 -0.3 3.38e-8 Drug-induced liver injury (flucloxacillin); CRC cis rs6502050 0.835 rs4789672 chr17:80126603 T/C cg19223190 chr17:80058835 NA 0.39 6.21 0.32 1.63e-9 Life satisfaction; CRC trans rs1005277 0.505 rs13503 chr10:38239843 C/A cg17830980 chr10:43048298 ZNF37B 0.4 6.23 0.32 1.47e-9 Extrinsic epigenetic age acceleration; CRC cis rs1065656 0.571 rs12149777 chr16:1834724 A/G cg09540102 chr16:1822124 NME3;MRPS34;EME2 -0.42 -6.62 -0.34 1.49e-10 Insulin-like growth factors; CRC cis rs12612619 0.761 rs7606840 chr2:27243364 A/G cg00617064 chr2:27272375 NA -0.37 -6.13 -0.32 2.51e-9 Venous thromboembolism adjusted for sickle cell variant rs77121243-T; CRC cis rs57590327 0.503 rs12152272 chr3:81911684 G/A cg07356753 chr3:81810745 GBE1 -0.58 -7.83 -0.4 6.76e-14 Extraversion; CRC cis rs2832191 0.791 rs2065270 chr21:30485420 T/C cg08807101 chr21:30365312 RNF160 -0.65 -10.66 -0.51 5.57e-23 Dental caries; CRC cis rs1552244 0.751 rs12715665 chr3:10021601 C/T cg10729496 chr3:10149963 C3orf24 0.45 6.08 0.32 3.26e-9 Alzheimer's disease; CRC cis rs3764400 0.567 rs2325784 chr17:46212309 A/G cg10706073 chr17:46328419 SKAP1 0.62 6.52 0.34 2.7e-10 Body mass index; CRC cis rs9549328 0.520 rs36144023 chr13:113616592 T/C cg24588162 chr13:113633484 MCF2L 0.36 6.43 0.33 4.47e-10 Systolic blood pressure; CRC cis rs10946940 0.864 rs13201411 chr6:27498217 G/C cg15845792 chr6:28175446 NA -0.47 -6.3 -0.33 9.61e-10 Systemic lupus erythematosus; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg27109827 chr16:28936530 RABEP2 0.38 6.19 0.32 1.79e-9 Liver disease severity in Alagille syndrome; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg16095951 chr6:108455178 NA 0.47 6.56 0.34 2.12e-10 Anxiety disorder; CRC cis rs6921919 0.638 rs9468344 chr6:28309569 A/C cg21251018 chr6:28226885 NKAPL 0.46 7.31 0.37 2.03e-12 Autism spectrum disorder or schizophrenia; CRC trans rs703108 0.731 rs7898954 chr10:22323646 A/G cg14559774 chr8:87355871 WWP1 -0.55 -6.71 -0.35 8.51e-11 Monocyte percentage of white cells; CRC cis rs2985684 1.000 rs11157696 chr14:50105746 C/G cg04989706 chr14:50066350 PPIL5 0.57 8.11 0.41 1e-14 Carotid intima media thickness; CRC cis rs17253792 0.822 rs78826571 chr14:56048906 G/A cg01858014 chr14:56050164 KTN1 -0.88 -7.09 -0.36 8.36e-12 Putamen volume; CRC cis rs9902453 1.000 rs4533340 chr17:28277951 G/C cg26525008 chr17:28256777 EFCAB5;SSH2 0.59 8.98 0.44 2.16e-17 Coffee consumption (cups per day); CRC cis rs1008375 1.000 rs1974624 chr4:17650281 A/G cg16339924 chr4:17578868 LAP3 0.54 7.27 0.37 2.62e-12 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs875971 0.756 rs4718328 chr7:65693337 A/G cg12463550 chr7:65579703 CRCP -0.53 -7.52 -0.38 5.19e-13 Aortic root size; CRC cis rs2153535 0.580 rs9393019 chr6:8462091 G/A cg07606381 chr6:8435919 SLC35B3 0.67 10.8 0.51 1.8e-23 Motion sickness; CRC cis rs9303401 0.659 rs17822807 chr17:56687190 A/C cg02118635 chr17:56770003 RAD51C;TEX14 0.82 9.85 0.48 3.23e-20 Cognitive test performance; CRC cis rs2573652 0.928 rs2581348 chr15:100514063 C/T cg00587665 chr15:100533223 ADAMTS17 -0.35 -6.02 -0.32 4.61e-9 Height; CRC cis rs919433 0.963 rs12618612 chr2:198171058 G/T cg20885578 chr2:198174922 NA -0.44 -6.99 -0.36 1.5e-11 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC cis rs2576037 0.583 rs11659693 chr18:44458733 C/T cg19077165 chr18:44547161 KATNAL2 -0.64 -11.11 -0.52 1.44e-24 Personality dimensions; CRC cis rs10131894 0.611 rs175000 chr14:75436367 T/C cg11812906 chr14:75593930 NEK9 -0.46 -6.99 -0.36 1.55e-11 Coronary artery disease; CRC cis rs3736485 0.966 rs7170217 chr15:51890678 A/G cg08986416 chr15:51914746 DMXL2 -0.45 -6.42 -0.33 4.76e-10 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs9322193 0.884 rs9688794 chr6:149953257 C/T cg07701084 chr6:150067640 NUP43 0.53 7.8 0.4 8.17e-14 Lung cancer; CRC cis rs11690935 0.959 rs10167419 chr2:172649826 A/G cg13550731 chr2:172543902 DYNC1I2 -1.06 -18.34 -0.71 3.1e-52 Schizophrenia; CRC cis rs12540874 0.507 rs4947644 chr7:50618876 C/T cg18232548 chr7:50535776 DDC 0.39 5.78 0.3 1.71e-8 Systemic sclerosis; CRC cis rs68170813 0.559 rs17427158 chr7:106824259 G/T cg02696742 chr7:106810147 HBP1 -0.61 -6.72 -0.35 8e-11 Coronary artery disease; CRC cis rs9399135 0.967 rs4376365 chr6:135307740 T/C cg24558204 chr6:135376177 HBS1L 0.5 7.79 0.39 8.78e-14 Red blood cell count; CRC cis rs7727544 0.507 rs10051679 chr5:131570931 T/A cg18758796 chr5:131593413 PDLIM4 0.47 8.28 0.42 3.22e-15 Blood metabolite levels; CRC cis rs4925386 1.000 rs4925389 chr20:60922512 G/A cg24112000 chr20:60950667 NA 0.52 8.99 0.44 2.01e-17 Colorectal cancer;Colorectal cancer (SNP x SNP interaction); CRC cis rs7666738 0.830 rs6819177 chr4:99040907 T/C cg05340658 chr4:99064831 C4orf37 0.6 9.45 0.46 6.36e-19 Colonoscopy-negative controls vs population controls; CRC cis rs473651 0.904 rs501333 chr2:239336045 G/A cg08773314 chr2:239334832 ASB1 0.39 8.85 0.44 5.65e-17 Multiple system atrophy; CRC cis rs10504073 0.584 rs4873307 chr8:49950417 C/T cg00325661 chr8:49890786 NA 0.58 10.47 0.5 2.54e-22 Blood metabolite ratios; CRC cis rs12477438 0.501 rs7349217 chr2:99815146 T/G cg14399236 chr2:99771627 LIPT1;TSGA10 0.76 13.08 0.58 9.08e-32 Chronic sinus infection; CRC cis rs2153535 0.540 rs9378557 chr6:8517381 T/C cg21535247 chr6:8435926 SLC35B3 0.49 7.47 0.38 7.33e-13 Motion sickness; CRC cis rs2730245 0.527 rs2527205 chr7:158706393 G/T cg24397884 chr7:158709396 WDR60 -0.82 -10.32 -0.49 8.21e-22 Height; CRC cis rs8077889 0.871 rs72836549 chr17:41904360 G/T cg26893861 chr17:41843967 DUSP3 0.95 12.4 0.56 3.22e-29 Triglycerides; CRC cis rs6502050 0.723 rs11657069 chr17:80083809 C/T cg09264619 chr17:80180166 NA 0.36 6.08 0.32 3.4e-9 Life satisfaction; CRC cis rs896854 0.818 rs13262110 chr8:95926890 C/T cg13393036 chr8:95962371 TP53INP1 -0.49 -7.99 -0.4 2.23e-14 Type 2 diabetes; CRC cis rs7258465 1.000 rs4808133 chr19:18608518 C/A cg06462663 chr19:18546047 ISYNA1 0.46 7.07 0.36 9.28e-12 Breast cancer; CRC cis rs172166 0.516 rs1225618 chr6:28129713 A/C cg15786705 chr6:28176104 NA 0.48 7.16 0.37 5.37e-12 Cardiac Troponin-T levels; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg23320034 chr20:60877648 ADRM1 0.4 6.04 0.32 4.13e-9 Intelligence (multi-trait analysis); CRC cis rs9399135 0.967 rs10872427 chr6:135353452 T/C cg24558204 chr6:135376177 HBS1L 0.51 8.07 0.41 1.34e-14 Red blood cell count; CRC trans rs1979967 0.524 rs79248142 chr15:79657091 G/A cg14802097 chr12:42970349 PRICKLE1 0.52 6.06 0.32 3.66e-9 Interleukin-18 levels; CRC cis rs6570726 0.935 rs422540 chr6:145837815 G/T cg23711669 chr6:146136114 FBXO30 0.68 12.16 0.56 2.33e-28 Lobe attachment (rater-scored or self-reported); CRC cis rs1577917 0.839 rs6454492 chr6:86483214 A/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.48 -6.43 -0.33 4.49e-10 Response to antipsychotic treatment; CRC cis rs763121 0.853 rs2281020 chr22:39064406 A/G cg06544989 chr22:39130855 UNC84B 0.46 7.11 0.37 7.19e-12 Menopause (age at onset); CRC cis rs1218582 0.772 rs11264290 chr1:154912300 C/T cg09359103 chr1:154839909 KCNN3 -0.7 -12.19 -0.56 1.89e-28 Prostate cancer; CRC cis rs17376456 0.825 rs12716454 chr5:93272279 A/C cg25358565 chr5:93447407 FAM172A 1.12 10.53 0.5 1.51e-22 Diabetic retinopathy; CRC cis rs13108904 0.967 rs13109112 chr4:1290481 C/A cg19318889 chr4:1322082 MAEA 0.4 5.66 0.3 3.25e-8 Obesity-related traits; CRC cis rs853679 0.517 rs9368551 chr6:28061792 A/G cg02631126 chr6:28058918 ZSCAN12L1 0.3 6.09 0.32 3.18e-9 Depression; CRC cis rs1552244 0.572 rs68121641 chr3:10165845 T/A cg18598329 chr3:10140678 FANCD2;C3orf24 -0.91 -10.81 -0.51 1.62e-23 Alzheimer's disease; CRC cis rs1348850 0.793 rs6734528 chr2:178493731 G/A cg02961200 chr2:178257176 LOC100130691;AGPS 0.53 7.42 0.38 1.04e-12 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs3768617 0.510 rs3768618 chr1:183092491 C/A ch.1.3577855R chr1:183094577 LAMC1 0.89 15.86 0.66 1.84e-42 Fuchs's corneal dystrophy; CRC cis rs1707322 1.000 rs6661500 chr1:46465662 T/C cg06784218 chr1:46089804 CCDC17 0.52 9.0 0.44 1.8e-17 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs72781680 1.000 rs72798418 chr2:24188922 A/G cg08917208 chr2:24149416 ATAD2B 0.91 9.28 0.46 2.29e-18 Lymphocyte counts; CRC cis rs737008 0.960 rs11640295 chr16:11390728 C/G cg00044050 chr16:11439710 C16orf75 0.51 6.73 0.35 7.37e-11 Obesity-related traits; CRC cis rs12580194 0.593 rs7488940 chr12:55802591 C/T cg19537932 chr12:55886519 OR6C68 -0.72 -9.15 -0.45 6.31e-18 Cancer; CRC cis rs600626 0.588 rs11236526 chr11:75467605 G/A cg24262691 chr11:75473276 NA 0.51 7.77 0.39 1.02e-13 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CRC cis rs13108904 0.901 rs12642410 chr4:1308409 A/G cg02018176 chr4:1364513 KIAA1530 0.45 7.27 0.37 2.65e-12 Obesity-related traits; CRC cis rs7666738 0.830 rs7662389 chr4:99019892 G/A cg17366294 chr4:99064904 C4orf37 0.44 7.42 0.38 1.02e-12 Colonoscopy-negative controls vs population controls; CRC cis rs1448094 0.967 rs10779222 chr12:86330775 G/A cg02569458 chr12:86230093 RASSF9 0.37 6.47 0.34 3.47e-10 Major depressive disorder; CRC cis rs644799 1.000 rs514170 chr11:95556696 C/T cg03916912 chr11:95522834 CEP57;FAM76B 0.95 18.38 0.71 2.03e-52 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs1347297 0.756 rs10173183 chr2:179276427 C/T cg03991736 chr2:179345203 MIR548N;PLEKHA3 -0.42 -5.78 -0.3 1.69e-8 Alzheimer disease and age of onset; CRC cis rs9926296 0.643 rs2159114 chr16:89831841 A/G cg04287289 chr16:89883240 FANCA 0.53 8.16 0.41 7.18e-15 Vitiligo; CRC cis rs7412746 0.622 rs11552229 chr1:150783985 T/C cg17724175 chr1:150552817 MCL1 0.47 6.97 0.36 1.74e-11 Melanoma; CRC cis rs7615952 0.534 rs1503072 chr3:125754691 C/T cg06494592 chr3:125709126 NA -0.55 -6.43 -0.33 4.43e-10 Blood pressure (smoking interaction); CRC cis rs7811142 1.000 rs67163493 chr7:100023838 C/T cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.16 17.33 0.69 2.96e-48 Platelet count; CRC cis rs9814567 1.000 rs9883753 chr3:134247231 T/C cg06541857 chr3:134203789 ANAPC13;CEP63 -0.38 -5.64 -0.3 3.64e-8 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs7208859 0.673 rs60020217 chr17:29185054 G/A cg14008862 chr17:28927542 LRRC37B2 0.55 5.74 0.3 2.1e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs2242116 0.932 rs4683301 chr3:46931478 A/T cg02527881 chr3:46936655 PTH1R 0.59 11.8 0.55 4.99e-27 Birth weight; CRC cis rs12048904 0.505 rs6577209 chr1:101255080 A/C cg16556008 chr1:101360663 SLC30A7;EXTL2 0.77 11.66 0.54 1.52e-26 Multiple sclerosis; CRC cis rs4819052 0.851 rs7279182 chr21:46656112 G/A cg02159808 chr21:46707872 POFUT2;LOC642852 0.46 5.87 0.31 1.08e-8 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs208520 0.661 rs207079 chr6:66770462 C/T cg07460842 chr6:66804631 NA -1.07 -14.78 -0.63 2.8900000000000003e-38 Exhaled nitric oxide output; CRC cis rs826838 0.935 rs1843639 chr12:39178919 C/A cg26384229 chr12:38710491 ALG10B 0.69 9.46 0.46 6.22e-19 Heart rate; CRC cis rs1552244 1.000 rs67134728 chr3:10151431 G/C cg02579736 chr3:10068473 FANCD2;CIDECP 1.03 13.67 0.6 5.38e-34 Alzheimer's disease; CRC cis rs9462027 0.628 rs11757370 chr6:34760736 T/C cg07306190 chr6:34760872 UHRF1BP1 -0.35 -6.24 -0.33 1.31e-9 Systemic lupus erythematosus; CRC cis rs77861329 0.920 rs808787 chr3:52203249 G/A cg08692210 chr3:52188851 WDR51A 0.87 8.16 0.41 7.07e-15 Macrophage inflammatory protein 1b levels; CRC cis rs9467711 0.606 rs9379864 chr6:26372584 G/A cg14345882 chr6:26364793 BTN3A2 0.65 5.73 0.3 2.32e-8 Autism spectrum disorder or schizophrenia; CRC cis rs2832191 0.671 rs68101501 chr21:30513229 G/T cg08807101 chr21:30365312 RNF160 -0.52 -7.28 -0.37 2.48e-12 Dental caries; CRC cis rs9674544 0.757 rs3744085 chr17:47131901 A/G cg10950924 chr17:47092072 IGF2BP1 -0.37 -6.02 -0.32 4.56e-9 Primary tooth development (time to first tooth eruption);Primary tooth development (number of teeth); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg04977951 chr14:99947745 SETD3;CCNK 0.39 6.36 0.33 6.65e-10 Liver disease severity in Alagille syndrome; CRC cis rs9311474 0.508 rs11714565 chr3:52606292 C/T cg18404041 chr3:52824283 ITIH1 -0.4 -8.56 -0.43 4.28e-16 Electroencephalogram traits; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg04738279 chr17:46696432 NA 0.43 6.26 0.33 1.23e-9 Intelligence (multi-trait analysis); CRC cis rs10197940 0.662 rs72860233 chr2:152289767 G/A cg06191203 chr2:152266755 RIF1 -0.7 -10.15 -0.49 3.08e-21 Lung cancer; CRC cis rs208520 1.000 rs12190316 chr6:66973365 T/C cg07460842 chr6:66804631 NA 0.89 10.75 0.51 2.56e-23 Exhaled nitric oxide output; CRC cis rs79149102 0.579 rs7342591 chr15:75306863 C/T cg09165964 chr15:75287851 SCAMP5 0.59 6.3 0.33 9.35e-10 Lung cancer; CRC cis rs798554 0.660 rs2527687 chr7:2838485 G/A cg09658497 chr7:2847517 GNA12 -0.38 -5.91 -0.31 8.66e-9 Height; CRC cis rs9309711 0.922 rs13385119 chr2:3484521 G/A cg10845886 chr2:3471009 TTC15 -0.72 -11.53 -0.54 4.62e-26 Neurofibrillary tangles; CRC cis rs2976388 0.647 rs2572906 chr8:143798269 G/A cg04969067 chr8:143858791 LYNX1 0.44 7.59 0.39 3.29e-13 Urinary tract infection frequency; CRC cis rs7523050 0.730 rs77425121 chr1:109417677 C/A cg08274380 chr1:109419600 GPSM2 0.89 7.75 0.39 1.18e-13 Fat distribution (HIV); CRC cis rs9911578 0.805 rs12601867 chr17:56455260 C/G cg12560992 chr17:57184187 TRIM37 -0.77 -13.37 -0.59 7.52e-33 Intelligence (multi-trait analysis); CRC cis rs13392177 0.637 rs61041183 chr2:219056380 G/A cg00012203 chr2:219082015 ARPC2 0.5 7.54 0.38 4.76e-13 Pyoderma gangrenosum in inflammatory bowel disease; CRC trans rs3858526 0.959 rs11039699 chr11:5951091 G/A cg01505111 chr6:125621795 HDDC2 0.38 6.04 0.32 4.06e-9 DNA methylation (variation); CRC cis rs240764 0.578 rs11155613 chr6:101176642 T/C cg09795085 chr6:101329169 ASCC3 0.43 5.96 0.31 6.37e-9 Neuroticism; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg01131735 chr17:39968419 FKBP10;SC65 0.4 5.98 0.31 5.7e-9 Intelligence (multi-trait analysis); CRC trans rs2303319 0.504 rs62189053 chr2:162624324 G/A cg10272801 chr16:14013773 ERCC4 -0.68 -6.07 -0.32 3.49e-9 Cognitive function; CRC cis rs9322193 0.772 rs7738696 chr6:150170121 A/G cg07701084 chr6:150067640 NUP43 0.52 7.55 0.38 4.4e-13 Lung cancer; CRC cis rs4665809 0.590 rs1469523 chr2:26474631 T/A cg27170947 chr2:26402098 FAM59B 0.6 7.82 0.4 7.45e-14 Gut microbiome composition (summer); CRC cis rs870825 0.929 rs10003354 chr4:185589782 G/A cg04058563 chr4:185651563 MLF1IP 0.57 5.95 0.31 6.86e-9 Blood protein levels; CRC cis rs644799 1.000 rs474252 chr11:95619292 G/C cg25478527 chr11:95522999 CEP57;FAM76B 0.5 7.46 0.38 7.95e-13 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs9858542 1.000 rs13316695 chr3:49684917 C/G cg03060546 chr3:49711283 APEH -0.5 -6.78 -0.35 5.72e-11 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs12220238 0.818 rs10824082 chr10:75904080 C/T cg19889307 chr10:75911429 ADK;AP3M1 0.64 6.42 0.33 4.71e-10 Soluble interleukin-2 receptor subunit alpha; CRC cis rs4665809 0.556 rs4665314 chr2:26415912 T/C cg25036284 chr2:26402008 FAM59B -0.61 -7.7 -0.39 1.63e-13 Gut microbiome composition (summer); CRC cis rs1218582 0.772 rs4240875 chr1:154885782 G/A cg06221963 chr1:154839813 KCNN3 -0.77 -15.48 -0.65 5.67e-41 Prostate cancer; CRC cis rs11971779 0.648 rs6974099 chr7:139098566 A/T cg07862535 chr7:139043722 LUC7L2 0.57 7.32 0.37 1.92e-12 Diisocyanate-induced asthma; CRC cis rs780096 0.587 rs6760828 chr2:27579231 T/C cg27432699 chr2:27873401 GPN1 -0.51 -7.64 -0.39 2.38e-13 Total body bone mineral density; CRC cis rs910187 0.571 rs3746489 chr20:45801716 C/T cg27589058 chr20:45804311 EYA2 -0.4 -7.54 -0.38 4.59e-13 Migraine; CRC cis rs1552244 0.882 rs6443276 chr3:10008905 C/A cg16606324 chr3:10149918 C3orf24 0.61 8.03 0.4 1.7e-14 Alzheimer's disease; CRC cis rs4332037 1.000 rs4332037 chr7:1950809 C/T cg23422044 chr7:1970798 MAD1L1 -0.55 -7.02 -0.36 1.27e-11 Bipolar disorder; CRC cis rs12594515 1.000 rs6493168 chr15:45986811 A/C cg19682013 chr15:45996608 NA 0.33 6.78 0.35 5.7e-11 Waist circumference;Weight; CRC cis rs13064411 0.696 rs13066742 chr3:113208423 T/C cg18753928 chr3:113234510 CCDC52 -0.7 -10.68 -0.51 4.62e-23 Response to simvastatin treatment (PCSK9 protein level change); CRC cis rs2404602 0.716 rs17461634 chr15:76764107 G/A cg00316803 chr15:76480434 C15orf27 -0.34 -5.61 -0.3 4.2e-8 Blood metabolite levels; CRC trans rs7615952 0.599 rs60847438 chr3:125746005 T/C cg07211511 chr3:129823064 LOC729375 -0.77 -10.24 -0.49 1.47e-21 Blood pressure (smoking interaction); CRC cis rs7100689 0.784 rs4258322 chr10:82184770 T/C cg00277334 chr10:82204260 NA -0.46 -6.04 -0.32 4.13e-9 Post bronchodilator FEV1; CRC cis rs847577 0.575 rs41278842 chr7:97815999 A/G cg21770322 chr7:97807741 LMTK2 -0.69 -12.39 -0.56 3.3600000000000003e-29 Breast cancer; CRC cis rs6761276 0.674 rs3811056 chr2:113831183 T/C cg12858261 chr2:113808755 IL1F8 0.46 6.68 0.35 1.02e-10 Protein quantitative trait loci; CRC cis rs896543 0.702 rs12692189 chr2:237496112 A/G cg25295825 chr2:237489920 CXCR7 -0.45 -7.26 -0.37 2.87e-12 Alcohol dependence (age at onset); CRC cis rs12745968 0.589 rs3936944 chr1:93106958 C/T cg17283838 chr1:93427260 FAM69A -0.47 -6.38 -0.33 6.1e-10 Bipolar disorder and schizophrenia; CRC cis rs4363385 0.530 rs6663448 chr1:152894627 C/T cg25856811 chr1:152973957 SPRR3 -0.21 -5.62 -0.3 4.03e-8 Inflammatory skin disease; CRC cis rs4332037 0.615 rs62435134 chr7:1895463 T/G cg21155852 chr7:2048760 MAD1L1 -0.46 -6.39 -0.33 5.79e-10 Bipolar disorder; CRC cis rs4243830 0.737 rs4908926 chr1:6617041 C/T cg22792644 chr1:6614718 TAS1R1;NOL9 -0.82 -9.92 -0.48 1.79e-20 Body mass index; CRC cis rs1387259 0.758 rs2634670 chr12:48771877 G/A cg04545296 chr12:48745243 ZNF641 0.35 6.07 0.32 3.57e-9 Obstructive sleep apnea trait (apnea hypopnea index); CRC cis rs4713118 0.662 rs149961 chr6:28015569 A/C cg15845792 chr6:28175446 NA 0.9 13.02 0.58 1.52e-31 Parkinson's disease; CRC cis rs6121246 0.909 rs6119729 chr20:30413163 A/G cg13852791 chr20:30311386 BCL2L1 -0.69 -10.95 -0.52 5.43e-24 Mean corpuscular hemoglobin; CRC cis rs7771547 0.573 rs629721 chr6:36398229 T/C cg07856975 chr6:36356162 ETV7 0.4 5.76 0.3 1.91e-8 Platelet distribution width; CRC cis rs7044106 0.762 rs1530370 chr9:123424552 C/T cg14255062 chr9:123606675 PSMD5;LOC253039 0.43 6.31 0.33 9.03e-10 Hip circumference adjusted for BMI; CRC cis rs2576037 0.545 rs9948405 chr18:44494527 C/G cg19077165 chr18:44547161 KATNAL2 -0.69 -11.83 -0.55 3.91e-27 Personality dimensions; CRC cis rs2153535 0.580 rs2327064 chr6:8454052 C/T cg21535247 chr6:8435926 SLC35B3 0.48 7.29 0.37 2.37e-12 Motion sickness; CRC cis rs2878628 0.596 rs57039206 chr3:52758570 T/A cg15147215 chr3:52552868 STAB1 -0.63 -10.66 -0.51 5.33e-23 Intelligence (multi-trait analysis); CRC cis rs875971 0.862 rs6971059 chr7:66067032 A/G cg18876405 chr7:65276391 NA -0.54 -8.65 -0.43 2.29e-16 Aortic root size; CRC cis rs2019137 0.936 rs3811059 chr2:113962071 C/T cg12889195 chr2:113992843 PAX8;LOC440839;LOC654433 -0.52 -7.46 -0.38 7.96e-13 Lymphocyte counts; CRC cis rs6952808 1.000 rs4721121 chr7:1892565 A/G cg20295408 chr7:1910781 MAD1L1 -0.4 -5.72 -0.3 2.45e-8 Bipolar disorder and schizophrenia; CRC trans rs7824557 0.564 rs2572399 chr8:11234520 A/G cg06636001 chr8:8085503 FLJ10661 -0.47 -7.2 -0.37 4.21e-12 Retinal vascular caliber; CRC cis rs7020830 0.867 rs7852593 chr9:37332380 A/T cg14294708 chr9:37120828 ZCCHC7 1.13 24.16 0.8 7.25e-75 Schizophrenia; CRC cis rs7113874 0.550 rs10840085 chr11:8613949 A/G cg02811074 chr11:8615871 STK33 0.32 5.7 0.3 2.73e-8 Body mass index in physically active individuals;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs11229555 0.874 rs10896787 chr11:58285494 G/T cg15696309 chr11:58395628 NA -0.96 -12.66 -0.57 3.49e-30 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; CRC cis rs16867335 1.000 rs2113786 chr2:181483250 C/T cg23363182 chr2:181467187 NA -0.48 -6.49 -0.34 3.17e-10 Survival in rectal cancer; CRC cis rs2576037 0.526 rs626217 chr18:44429182 T/G cg24750912 chr18:44543259 TCEB3CL;KATNAL2 0.28 5.69 0.3 2.86e-8 Personality dimensions; CRC cis rs2346177 0.576 rs1530621 chr2:46688688 T/C cg02822958 chr2:46747628 ATP6V1E2 0.43 6.07 0.32 3.47e-9 HDL cholesterol; CRC trans rs9858542 0.953 rs9824092 chr3:49674147 C/G cg21659725 chr3:3221576 CRBN -0.73 -9.61 -0.47 1.99e-19 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC trans rs7647973 0.667 rs11721148 chr3:49646669 G/A cg21665057 chr3:196295764 WDR53;FBXO45 -0.65 -7.03 -0.36 1.17e-11 Menarche (age at onset); CRC cis rs801193 0.967 rs2707853 chr7:66214010 G/A cg18876405 chr7:65276391 NA 0.6 10.61 0.51 7.98e-23 Aortic root size; CRC cis rs7917772 0.503 rs7093285 chr10:104374815 G/C cg04362960 chr10:104952993 NT5C2 -0.44 -6.21 -0.32 1.59e-9 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC cis rs2075371 0.501 rs1421469 chr7:134028260 C/G cg02659138 chr7:134003124 SLC35B4 0.35 5.99 0.31 5.54e-9 Mean platelet volume; CRC cis rs501120 0.584 rs11595946 chr10:44685695 C/T cg09554077 chr10:44749378 NA 0.68 7.29 0.37 2.38e-12 Coronary artery disease;Coronary heart disease; CRC cis rs12950390 0.853 rs59513807 chr17:45867925 G/A cg24803719 chr17:45855879 NA -0.31 -6.92 -0.36 2.44e-11 IgG glycosylation; CRC cis rs854765 0.964 rs854764 chr17:18011750 A/G cg16928487 chr17:17741425 SREBF1 0.58 8.57 0.43 4.13e-16 Total body bone mineral density; CRC cis rs35000415 1.000 rs35000415 chr7:128585616 C/T cg19972273 chr7:128594194 NA 0.67 5.99 0.31 5.56e-9 Systemic lupus erythematosus; CRC cis rs875971 0.862 rs6460302 chr7:65960257 C/G cg00343986 chr7:65444356 GUSB 0.43 6.08 0.32 3.31e-9 Aortic root size; CRC trans rs2727020 0.576 rs61885308 chr11:49343363 G/A cg15704280 chr7:45808275 SEPT13 -0.63 -9.76 -0.47 6.25e-20 Coronary artery disease; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg11178170 chr4:184427252 ING2 0.45 7.45 0.38 8.21e-13 Liver disease severity in Alagille syndrome; CRC cis rs6061231 0.624 rs8668 chr20:60964064 C/T cg24112000 chr20:60950667 NA 0.53 9.1 0.45 8.59e-18 Colorectal cancer; CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg13896783 chr2:159313876 CCDC148;PKP4 0.39 6.22 0.32 1.49e-9 Obesity-related traits; CRC cis rs2836974 0.644 rs7281853 chr21:40693490 A/G cg17971929 chr21:40555470 PSMG1 -0.62 -8.73 -0.43 1.27e-16 Cognitive function; CRC cis rs1506636 1.000 rs60689684 chr7:123370403 C/T cg03229431 chr7:123269106 ASB15 0.76 11.08 0.52 1.92e-24 Plateletcrit;Platelet count; CRC cis rs4509693 0.943 rs4917907 chr10:102498140 A/G cg23167259 chr10:102495509 NA -0.47 -6.35 -0.33 6.97e-10 Alzheimer's disease; CRC cis rs853679 0.517 rs9380049 chr6:28048535 A/G cg12172441 chr6:28176163 NA 0.59 7.12 0.37 6.82e-12 Depression; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg00076854 chr13:29233041 POMP 0.43 6.19 0.32 1.77e-9 Intelligence (multi-trait analysis); CRC cis rs1552244 1.000 rs9820598 chr3:10117912 C/G cg08888203 chr3:10149979 C3orf24 0.7 10.07 0.49 5.94e-21 Alzheimer's disease; CRC cis rs4474465 1.000 rs10899518 chr11:78180508 A/C cg27205649 chr11:78285834 NARS2 -0.48 -5.8 -0.3 1.57e-8 Alzheimer's disease (survival time); CRC cis rs12048904 0.619 rs12239082 chr1:101330077 G/T cg15686842 chr1:101360669 SLC30A7;EXTL2 -0.59 -8.1 -0.41 1.1e-14 Multiple sclerosis; CRC cis rs67311347 0.822 rs9826847 chr3:40345312 A/T cg09455208 chr3:40491958 NA 0.36 7.01 0.36 1.35e-11 Renal cell carcinoma; CRC cis rs977987 0.843 rs59155720 chr16:75483806 A/G cg03315344 chr16:75512273 CHST6 0.55 9.23 0.45 3.4e-18 Dupuytren's disease; CRC cis rs6570726 0.935 rs380433 chr6:145859601 A/T cg23711669 chr6:146136114 FBXO30 0.7 12.46 0.57 1.8e-29 Lobe attachment (rater-scored or self-reported); CRC trans rs9447004 0.966 rs9343078 chr6:74489384 A/G cg03014589 chr8:144965836 NA 0.2 5.98 0.31 5.91e-9 Blood protein levels;Calcium levels; CRC trans rs1814175 0.817 rs4881648 chr11:49812901 A/G cg21153622 chr11:89784906 NA -0.38 -6.04 -0.32 4.13e-9 Height; CRC cis rs6502050 0.799 rs8069827 chr17:80089168 C/T cg19223190 chr17:80058835 NA 0.39 6.16 0.32 2.12e-9 Life satisfaction; CRC cis rs501120 1.000 rs604674 chr10:44756894 G/T cg09554077 chr10:44749378 NA 0.78 12.0 0.55 9.18e-28 Coronary artery disease;Coronary heart disease; CRC cis rs13118159 0.872 rs1882105 chr4:1345956 T/C cg20887711 chr4:1340912 KIAA1530 0.43 5.83 0.31 1.35e-8 Longevity; CRC cis rs2204008 0.805 rs11514348 chr12:38243427 T/C cg13010199 chr12:38710504 ALG10B 0.45 5.75 0.3 2.07e-8 Bladder cancer; CRC cis rs870825 0.616 rs7681824 chr4:185617525 A/G cg04058563 chr4:185651563 MLF1IP 0.72 9.36 0.46 1.32e-18 Blood protein levels; CRC cis rs13191362 0.935 rs73037930 chr6:162937146 A/C cg21926612 chr6:163149169 PACRG;PARK2 0.8 9.55 0.47 3e-19 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs9372498 0.536 rs9489409 chr6:118802721 A/G cg07617317 chr6:118971624 C6orf204 0.51 6.26 0.33 1.17e-9 Diastolic blood pressure; CRC cis rs4862750 0.872 rs6821507 chr4:187876829 G/T cg03647317 chr4:187891568 NA 0.54 10.22 0.49 1.79e-21 Lobe attachment (rater-scored or self-reported); CRC cis rs2281845 0.791 rs1325313 chr1:201076167 C/T cg08885800 chr1:201084119 NA 0.42 7.42 0.38 9.88e-13 Permanent tooth development; CRC cis rs344364 0.511 rs911392 chr16:1947259 A/G cg09830162 chr16:1889614 FAHD1;C16orf73 -0.76 -9.28 -0.46 2.34e-18 Glomerular filtration rate in chronic kidney disease; CRC cis rs2276314 1.000 rs2298715 chr18:33552425 T/C cg19628046 chr18:33552617 C18orf21 0.54 7.25 0.37 2.93e-12 Endometriosis;Drug-induced torsades de pointes; CRC cis rs68170813 0.559 rs4730232 chr7:106942382 G/C cg02696742 chr7:106810147 HBP1 -0.57 -6.32 -0.33 8.44e-10 Coronary artery disease; CRC cis rs7147624 1.000 rs7160390 chr14:66052460 G/A cg03016385 chr14:66212404 NA -1.05 -10.86 -0.51 1.12e-23 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs4728302 0.869 rs13228262 chr7:133598288 A/G cg10665199 chr7:133106180 EXOC4 0.38 5.77 0.3 1.8e-8 Intelligence;Intelligence (multi-trait analysis); CRC cis rs765787 0.530 rs11854689 chr15:45516052 A/G cg24006582 chr15:45444508 DUOX1 -0.57 -8.75 -0.43 1.15e-16 Uric acid levels; CRC trans rs3942852 0.806 rs10838805 chr11:48118993 A/C cg03929089 chr4:120376271 NA -0.56 -7.09 -0.36 8.41e-12 Acute lymphoblastic leukemia (childhood); CRC cis rs9457247 0.967 rs388406 chr6:167409562 A/G cg23791538 chr6:167370224 RNASET2 -0.39 -6.08 -0.32 3.37e-9 Crohn's disease; CRC cis rs138880 0.542 rs9616371 chr22:50306338 G/A cg22709217 chr22:50311962 ALG12;CRELD2 -1.03 -10.57 -0.5 1.15e-22 Schizophrenia; CRC cis rs7762018 0.760 rs28660085 chr6:170101996 C/G cg15038512 chr6:170123185 PHF10 0.58 7.91 0.4 3.85e-14 Thiazide-induced adverse metabolic effects in hypertensive patients; CRC trans rs6076960 0.629 rs6054008 chr20:6212370 C/T cg17788362 chr6:86352627 SYNCRIP 0.49 6.76 0.35 6.43e-11 Smooth-surface caries; CRC cis rs2346177 0.580 rs1530628 chr2:46670941 A/G cg02822958 chr2:46747628 ATP6V1E2 0.42 6.89 0.36 2.83e-11 HDL cholesterol; CRC cis rs9486719 0.947 rs9398072 chr6:96911304 T/C cg06623918 chr6:96969491 KIAA0776 0.8 10.83 0.51 1.4e-23 Migraine;Coronary artery disease; CRC cis rs6952808 0.575 rs2056479 chr7:1954273 G/A cg22963979 chr7:1858916 MAD1L1 -0.41 -6.46 -0.34 3.72e-10 Bipolar disorder and schizophrenia; CRC cis rs8062405 0.755 rs56272201 chr16:28580685 A/G cg16576597 chr16:28551801 NUPR1 0.51 6.99 0.36 1.51e-11 Cognitive ability (multi-trait analysis);Cognitive ability; CRC cis rs7829975 0.686 rs907180 chr8:8702827 A/G cg06636001 chr8:8085503 FLJ10661 0.46 7.1 0.36 7.9e-12 Mood instability; CRC cis rs1552244 0.882 rs68080705 chr3:10025743 C/T cg10729496 chr3:10149963 C3orf24 0.47 6.05 0.32 3.84e-9 Alzheimer's disease; CRC cis rs1003719 0.762 rs3787786 chr21:38463436 T/C cg10648535 chr21:38446584 PIGP;TTC3 0.52 7.41 0.38 1.07e-12 Eye color traits; CRC cis rs7224685 0.501 rs4790168 chr17:4022457 T/C cg09695851 chr17:3907499 NA -0.77 -13.83 -0.61 1.28e-34 Type 2 diabetes; CRC cis rs4321325 0.733 rs74707659 chr2:127945469 T/C cg11380483 chr2:127933992 NA 0.61 7.07 0.36 9.36e-12 Protein C levels; CRC cis rs10946940 0.965 rs62401383 chr6:27564547 C/T cg02683197 chr6:28174875 NA -0.53 -7.32 -0.37 1.94e-12 Systemic lupus erythematosus; CRC cis rs7914558 1.000 rs12780843 chr10:104769335 G/C cg15744005 chr10:104629667 AS3MT -0.32 -6.83 -0.35 4.22e-11 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC trans rs11825064 0.666 rs2000859 chr11:134485499 T/G cg00033773 chr19:12779366 MORG1;C19orf56 0.45 6.17 0.32 1.97e-9 Seasonality; CRC cis rs950169 0.840 rs4842853 chr15:84942304 G/T cg17507749 chr15:85114479 UBE2QP1 0.74 10.59 0.5 9.91e-23 Schizophrenia; CRC cis rs17270561 0.779 rs78589800 chr6:25883500 C/G cg17691542 chr6:26056736 HIST1H1C 0.79 10.03 0.48 7.6e-21 Iron status biomarkers; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg10687823 chr19:36103576 HAUS5 0.48 6.73 0.35 7.6e-11 Anxiety disorder; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg13244110 chr17:40688572 NAGLU 0.42 6.02 0.31 4.64e-9 Intelligence (multi-trait analysis); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg25130390 chr15:65810150 DPP8 0.4 6.67 0.35 1.08e-10 Liver disease severity in Alagille syndrome; CRC cis rs908922 0.676 rs4845782 chr1:152492225 A/G cg23254163 chr1:152506842 NA 0.5 10.08 0.49 5.16e-21 Hair morphology; CRC cis rs8114671 0.804 rs6060139 chr20:33566499 T/C cg07148914 chr20:33460835 GGT7 0.35 5.64 0.3 3.6e-8 Height; CRC cis rs1799949 1.000 rs8176133 chr17:41257458 A/C cg23758822 chr17:41437982 NA 0.81 13.42 0.59 4.56e-33 Menopause (age at onset); CRC cis rs9322193 0.926 rs952166 chr6:150119910 A/T cg07701084 chr6:150067640 NUP43 0.47 6.61 0.34 1.51e-10 Lung cancer; CRC cis rs79839061 0.518 rs3755960 chr4:895060 G/T cg07828340 chr4:882639 GAK 1.17 11.46 0.53 8.2e-26 Intelligence (multi-trait analysis); CRC cis rs796364 0.906 rs281789 chr2:200780698 T/G cg25936922 chr2:200820526 C2orf60;C2orf47 0.71 7.82 0.4 7.38e-14 Schizophrenia; CRC cis rs12479064 0.724 rs62153852 chr2:99934713 C/T cg14399236 chr2:99771627 LIPT1;TSGA10 -0.62 -7.4 -0.38 1.16e-12 Chronic sinus infection; CRC cis rs2380220 1.000 rs9632496 chr6:95976450 C/G cg07718321 chr6:96025334 MANEA 0.48 5.7 0.3 2.64e-8 Behavioural disinhibition (generation interaction); CRC cis rs3790645 1.000 rs34062688 chr1:26887150 A/G cg17456097 chr1:26900765 RPS6KA1 0.42 6.28 0.33 1.08e-9 Glucose homeostasis traits; CRC cis rs6502050 0.835 rs8073645 chr17:80110957 C/T cg11859384 chr17:80120422 CCDC57 -0.37 -5.85 -0.31 1.16e-8 Life satisfaction; CRC cis rs911555 0.755 rs11620897 chr14:103944861 T/G cg12935359 chr14:103987150 CKB -0.55 -9.17 -0.45 5.15e-18 Intelligence (multi-trait analysis); CRC cis rs28386778 0.897 rs1062788 chr17:61896127 C/G cg22520471 chr17:61851767 DDX42;CCDC47 0.75 11.75 0.54 7.35e-27 Prudent dietary pattern; CRC cis rs6032067 0.925 rs13042522 chr20:43829290 G/A cg10761708 chr20:43804764 PI3 0.51 5.65 0.3 3.57e-8 Blood protein levels; CRC cis rs4665809 1.000 rs4665821 chr2:26309949 A/C cg22920501 chr2:26401640 FAM59B -0.53 -7.16 -0.37 5.17e-12 Gut microbiome composition (summer); CRC cis rs10751667 0.666 rs7394992 chr11:980690 G/C ch.11.42038R chr11:967971 AP2A2 0.58 9.97 0.48 1.22e-20 Alzheimer's disease (late onset); CRC cis rs4664293 0.867 rs6732987 chr2:160582429 C/A cg08347373 chr2:160653686 CD302 -0.47 -7.43 -0.38 9.32e-13 Monocyte percentage of white cells; CRC cis rs10782582 0.593 rs11163915 chr1:76130199 C/T cg03433033 chr1:76189801 ACADM -0.42 -6.1 -0.32 2.94e-9 Daytime sleep phenotypes; CRC trans rs9858542 0.953 rs10640 chr3:49454277 G/A cg21659725 chr3:3221576 CRBN -0.63 -8.62 -0.43 2.84e-16 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs2836974 0.568 rs371625 chr21:40535271 A/G cg17971929 chr21:40555470 PSMG1 -0.74 -11.77 -0.54 6.3e-27 Cognitive function; CRC cis rs75422866 0.867 rs73104144 chr12:48088173 G/T cg14736327 chr12:48174669 SLC48A1 -0.79 -6.01 -0.31 4.92e-9 Pneumonia; CRC cis rs7659604 0.517 rs56311153 chr4:122729685 T/C cg19748678 chr4:122722346 EXOSC9 0.65 10.16 0.49 2.75e-21 Type 2 diabetes; CRC cis rs3785574 0.925 rs2727340 chr17:61970224 T/A cg23090583 chr17:61904693 PSMC5;FTSJ3 0.63 8.94 0.44 2.87e-17 Height; CRC cis rs12134245 0.776 rs12125947 chr1:91990487 T/C cg25838465 chr1:92012736 NA -0.67 -12.51 -0.57 1.18e-29 Breast cancer; CRC cis rs853679 0.517 rs9295758 chr6:28120663 C/G cg25164649 chr6:28176230 NA 0.78 9.66 0.47 1.33e-19 Depression; CRC cis rs6831352 0.959 rs6848050 chr4:100053733 T/C cg13256891 chr4:100009986 ADH5 0.61 8.71 0.43 1.48e-16 Alcohol dependence; CRC cis rs12908161 1.000 rs11637142 chr15:85295927 A/G cg11189052 chr15:85197271 WDR73 0.59 8.58 0.43 3.73e-16 Schizophrenia; CRC cis rs4979906 1.000 rs4979907 chr10:79451969 C/G cg26465532 chr10:79446426 NA -0.71 -6.85 -0.35 3.61e-11 Mortality in heart failure; CRC cis rs208520 0.837 rs208488 chr6:66926902 C/T cg07460842 chr6:66804631 NA -0.95 -12.37 -0.56 4.11e-29 Exhaled nitric oxide output; CRC cis rs6502050 0.799 rs7502533 chr17:80109778 A/G cg22110888 chr17:80059540 CCDC57 0.4 6.44 0.33 4.17e-10 Life satisfaction; CRC cis rs4512344 0.509 rs2409784 chr8:11396856 G/T cg08071915 chr8:12219732 FAM66A 0.34 5.94 0.31 7.07e-9 Bone ultrasound measurement (broadband ultrasound attenuation); CRC cis rs7224685 0.501 rs781827 chr17:3962965 G/A cg09597638 chr17:3907349 NA 0.63 11.56 0.54 3.65e-26 Type 2 diabetes; CRC cis rs853679 0.517 rs9393898 chr6:28130376 G/T cg02683197 chr6:28174875 NA 0.88 10.83 0.51 1.42e-23 Depression; CRC cis rs7772486 0.713 rs1986729 chr6:146194831 G/A cg13319975 chr6:146136371 FBXO30 -0.46 -6.85 -0.35 3.65e-11 Lobe attachment (rater-scored or self-reported); CRC cis rs9322193 0.961 rs9767713 chr6:149909377 T/G cg07701084 chr6:150067640 NUP43 0.54 7.46 0.38 7.8e-13 Lung cancer; CRC cis rs9911578 0.935 rs2302189 chr17:56584205 A/C cg12560992 chr17:57184187 TRIM37 -0.9 -16.34 -0.67 2.26e-44 Intelligence (multi-trait analysis); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg20470467 chr16:30886130 NA 0.5 7.02 0.36 1.3e-11 Response to antipsychotic treatment; CRC cis rs1707322 1.000 rs10890375 chr1:46406581 G/A cg03146154 chr1:46216737 IPP 0.5 7.07 0.36 9.58e-12 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs798554 0.757 rs1182178 chr7:2873763 G/A cg14895029 chr7:2775587 GNA12 -0.42 -6.14 -0.32 2.43e-9 Height; CRC cis rs57221529 0.664 rs72704802 chr5:554211 C/T cg17948913 chr5:572064 NA 0.58 6.53 0.34 2.55e-10 Lung disease severity in cystic fibrosis; CRC trans rs2243480 1.000 rs410128 chr7:65603173 C/T cg10756647 chr7:56101905 PSPH 0.75 7.44 0.38 8.66e-13 Diabetic kidney disease; CRC trans rs4276421 0.806 rs6451804 chr5:45492205 A/G cg04793272 chr11:119020941 ABCG4 -0.38 -6.3 -0.33 9.3e-10 P wave duration; CRC cis rs6062302 0.545 rs2297430 chr20:62229244 T/C cg06363034 chr20:62225388 GMEB2 -0.45 -6.88 -0.35 2.94e-11 Glioblastoma; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg16275967 chr1:161172255 NDUFS2 0.47 6.87 0.35 3.32e-11 Response to antipsychotic treatment; CRC cis rs9894429 0.789 rs7213849 chr17:79567610 C/T cg21984481 chr17:79567631 NPLOC4 0.58 11.05 0.52 2.45e-24 Eye color traits; CRC cis rs6424115 0.830 rs6680132 chr1:24198804 T/C cg10978503 chr1:24200527 CNR2 0.61 11.23 0.53 5.62e-25 Immature fraction of reticulocytes; CRC cis rs2839186 0.900 rs2839196 chr21:47708037 G/A cg05896524 chr21:47604654 C21orf56 0.46 6.64 0.34 1.28e-10 Testicular germ cell tumor; CRC cis rs7309 0.810 rs11684253 chr2:162034536 G/T cg22496339 chr2:162101262 NA 0.78 13.21 0.59 2.86e-32 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Educational attainment; CRC cis rs533581 0.866 rs475796 chr16:88970776 C/G cg16701003 chr16:89028210 CBFA2T3 0.42 6.42 0.33 4.86e-10 Social autistic-like traits; CRC cis rs9487051 0.676 rs6933326 chr6:109601333 C/T cg21918786 chr6:109611834 NA -0.39 -6.91 -0.36 2.53e-11 Reticulocyte fraction of red cells; CRC cis rs4601821 0.635 rs7114433 chr11:113208098 C/T cg14159747 chr11:113255604 NA 0.43 8.1 0.41 1.11e-14 Alcoholic chronic pancreatitis; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg23129613 chr7:150065255 REPIN1 0.47 6.85 0.35 3.72e-11 Response to antipsychotic treatment; CRC cis rs1878931 0.582 rs27232 chr16:3436782 G/A cg02880119 chr16:3481970 NA 0.42 5.91 0.31 8.62e-9 Body mass index (adult); CRC cis rs10256972 0.552 rs2949192 chr7:1203841 C/T cg27094323 chr7:1216898 NA -0.37 -6.21 -0.32 1.63e-9 Longevity;Endometriosis; CRC cis rs9916302 0.904 rs2338800 chr17:37498149 C/G cg15445000 chr17:37608096 MED1 -0.43 -9.63 -0.47 1.72e-19 Glomerular filtration rate (creatinine); CRC cis rs10927875 1.000 rs10927875 chr1:16299312 A/G cg21385522 chr1:16154831 NA 0.69 9.29 0.46 2.12e-18 Dilated cardiomyopathy; CRC cis rs155076 0.938 rs485361 chr13:21845826 G/T cg25811766 chr13:21894605 NA -0.57 -6.0 -0.31 5.12e-9 White matter hyperintensity burden; CRC cis rs425277 0.628 rs262668 chr1:2082602 A/G cg21194808 chr1:2205498 SKI 0.4 5.91 0.31 8.73e-9 Height; CRC cis rs12995491 0.731 rs17435433 chr2:88509616 A/G cg14558114 chr2:88469736 THNSL2 -0.42 -6.11 -0.32 2.86e-9 Response to metformin (IC50); CRC cis rs2882667 0.690 rs9327827 chr5:138182328 A/G cg09476006 chr5:138032270 NA 0.54 9.77 0.47 5.67e-20 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs28386778 0.863 rs6919 chr17:61909485 A/T cg23090583 chr17:61904693 PSMC5;FTSJ3 -1.02 -19.5 -0.73 8.13e-57 Prudent dietary pattern; CRC cis rs13256369 0.951 rs13270852 chr8:8566853 A/G cg17143192 chr8:8559678 CLDN23 0.5 6.35 0.33 6.96e-10 Obesity-related traits; CRC cis rs11625487 0.515 rs12434419 chr14:77855617 G/A cg20045696 chr14:77926864 AHSA1 -0.55 -8.93 -0.44 3.07e-17 Neutrophil percentage of white cells;Sum neutrophil eosinophil counts;Neutrophil count; CRC cis rs10870270 0.956 rs11146425 chr10:133734261 C/T cg08754478 chr10:133766260 PPP2R2D -0.65 -9.43 -0.46 7.78e-19 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; CRC cis rs875971 0.862 rs10240949 chr7:65804417 A/G cg00343986 chr7:65444356 GUSB -0.4 -5.66 -0.3 3.3e-8 Aortic root size; CRC cis rs58688157 0.705 rs12803132 chr11:586696 A/G cg07212818 chr11:638076 DRD4 -0.47 -5.9 -0.31 9.03e-9 Systemic lupus erythematosus; CRC cis rs3126085 0.935 rs1496051 chr1:152164923 G/A cg09127314 chr1:152161683 NA 0.49 6.18 0.32 1.88e-9 Atopic dermatitis; CRC cis rs270601 0.913 rs273899 chr5:131695178 G/A cg27615366 chr5:131592974 PDLIM4 0.33 5.78 0.3 1.7e-8 Acylcarnitine levels; CRC trans rs9291683 0.546 rs6829727 chr4:10051672 A/C cg26043149 chr18:55253948 FECH 0.53 7.85 0.4 5.73e-14 Bone mineral density; CRC cis rs9522267 0.535 rs7326875 chr13:112236231 C/T cg10483660 chr13:112241077 NA -0.48 -9.0 -0.44 1.85e-17 Hepatitis; CRC cis rs17826219 0.636 rs7221463 chr17:29080551 A/C cg13385521 chr17:29058706 SUZ12P 0.72 8.18 0.41 6.46e-15 Body mass index; CRC cis rs10463316 0.832 rs246484 chr5:150730938 T/C cg03212797 chr5:150827313 SLC36A1 -0.51 -7.98 -0.4 2.46e-14 Metabolite levels (Pyroglutamine); CRC cis rs1448094 0.511 rs61930037 chr12:86154503 G/A cg25456477 chr12:86230367 RASSF9 0.39 6.45 0.34 3.89e-10 Major depressive disorder; CRC cis rs853679 0.628 rs9368560 chr6:28159960 T/C cg15845792 chr6:28175446 NA 0.97 13.87 0.61 8.9e-35 Depression; CRC cis rs9467711 0.659 rs13195509 chr6:26463660 C/T cg08501292 chr6:25962987 TRIM38 0.85 5.77 0.3 1.79e-8 Autism spectrum disorder or schizophrenia; CRC cis rs4925325 0.741 rs6142886 chr20:60511190 A/G cg23262073 chr20:60523788 NA 0.54 8.75 0.43 1.13e-16 Obesity-related traits; CRC cis rs728616 0.558 rs72817596 chr10:82151594 T/C cg05935833 chr10:81318306 SFTPA2 -0.59 -7.28 -0.37 2.44e-12 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs7178572 0.568 rs7166927 chr15:77673459 A/G cg22256960 chr15:77711686 NA 0.69 9.92 0.48 1.77e-20 Type 2 diabetes; CRC cis rs4555082 0.874 rs2816626 chr14:105735425 G/A cg13114125 chr14:105738426 BRF1 -0.8 -11.56 -0.54 3.49e-26 Mean platelet volume;Platelet distribution width; CRC cis rs524023 0.958 rs2021860 chr11:64361384 G/T cg14139581 chr11:64358342 SLC22A12 -0.38 -6.12 -0.32 2.73e-9 Urate levels in obese individuals; CRC cis rs2019137 0.936 rs3828189 chr2:113954496 T/A cg07772999 chr2:113993052 PAX8;LOC440839;LOC654433 -0.45 -6.34 -0.33 7.77e-10 Lymphocyte counts; CRC cis rs7072216 0.881 rs2147895 chr10:100148308 T/G cg26618903 chr10:100175079 PYROXD2 -0.36 -6.1 -0.32 2.89e-9 Metabolite levels; CRC trans rs916888 0.821 rs199514 chr17:44856881 G/A cg22433210 chr17:43662623 NA -0.82 -8.83 -0.44 6.35e-17 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs4664308 1.000 rs4664308 chr2:160917497 A/G cg03641300 chr2:160917029 PLA2R1 -0.75 -12.15 -0.56 2.56e-28 Idiopathic membranous nephropathy; CRC trans rs7027930 0.524 rs7042862 chr9:612892 G/A cg27061366 chr19:13044373 FARSA 0.51 6.32 0.33 8.75e-10 Pulmonary function decline; CRC cis rs910873 0.505 rs2378249 chr20:33218090 G/A cg08999081 chr20:33150536 PIGU 0.49 6.13 0.32 2.57e-9 Melanoma; CRC cis rs2760061 0.784 rs1745414 chr1:228212159 T/A cg01200585 chr1:228362443 C1orf69 0.4 5.84 0.31 1.26e-8 Diastolic blood pressure; CRC cis rs4665809 0.590 rs4665321 chr2:26433801 A/C cg08067268 chr2:26466485 HADHB;HADHA -0.68 -8.61 -0.43 2.97e-16 Gut microbiome composition (summer); CRC cis rs6762477 0.748 rs11711407 chr3:50225029 A/G cg24110177 chr3:50126178 RBM5 0.42 6.34 0.33 7.67e-10 Menarche (age at onset); CRC trans rs7267979 1.000 rs2424713 chr20:25418482 C/T cg17903999 chr18:56338584 MALT1 -0.41 -6.61 -0.34 1.59e-10 Liver enzyme levels (alkaline phosphatase); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg24274600 chr5:95066816 RHOBTB3 0.43 6.08 0.32 3.42e-9 Response to antipsychotic treatment; CRC trans rs4689592 0.503 rs56099074 chr4:7071259 A/G cg07817883 chr1:32538562 TMEM39B 0.64 7.23 0.37 3.41e-12 Monocyte percentage of white cells; CRC cis rs898097 1.000 rs898097 chr17:80904310 C/T cg15664640 chr17:80829946 TBCD 0.59 9.79 0.47 5.12e-20 Breast cancer; CRC cis rs9911578 0.967 rs2611781 chr17:56703124 C/G cg12560992 chr17:57184187 TRIM37 0.91 16.29 0.67 3.68e-44 Intelligence (multi-trait analysis); CRC cis rs9837602 1.000 rs4571265 chr3:99705111 A/G cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G -0.48 -5.74 -0.3 2.13e-8 Breast cancer; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg12817423 chr12:80329258 PPP1R12A 0.4 5.98 0.31 5.9e-9 Liver disease severity in Alagille syndrome; CRC cis rs7119 0.931 rs12901998 chr15:77833524 G/T cg27398640 chr15:77910606 LINGO1 -0.4 -7.04 -0.36 1.11e-11 Type 2 diabetes; CRC cis rs5750830 0.649 rs4821893 chr22:39797779 G/A cg25459000 chr22:39777742 SYNGR1 -0.32 -5.66 -0.3 3.26e-8 Intelligence (multi-trait analysis); CRC cis rs11605275 1.000 rs11604681 chr11:20031042 G/A cg14835545 chr11:20032148 NAV2 -0.83 -5.66 -0.3 3.35e-8 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs57994353 0.897 rs12551527 chr9:139358425 C/G cg14119001 chr9:139324193 INPP5E -0.46 -6.43 -0.33 4.44e-10 Eosinophil counts;Cutaneous squamous cell carcinoma; CRC cis rs11997175 0.574 rs4364597 chr8:33653729 G/C ch.8.33884649F chr8:33765107 NA 0.47 7.62 0.39 2.73e-13 Body mass index; CRC cis rs7224685 0.501 rs4790559 chr17:4010478 G/T cg09597638 chr17:3907349 NA -0.68 -11.92 -0.55 1.86e-27 Type 2 diabetes; CRC cis rs11711311 0.911 rs34337798 chr3:113396704 C/T cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.5 -6.61 -0.34 1.51e-10 IgG glycosylation; CRC cis rs1451375 0.617 rs9942686 chr7:50596381 G/A cg18232548 chr7:50535776 DDC 0.45 5.88 0.31 9.91e-9 Malaria; CRC trans rs66887589 0.967 rs1155577 chr4:120449810 C/T cg25214090 chr10:38739885 LOC399744 -0.41 -6.42 -0.33 4.69e-10 Diastolic blood pressure; CRC cis rs929354 0.742 rs7801905 chr7:156940111 T/C cg16102536 chr7:156981717 UBE3C 0.4 6.69 0.35 9.57e-11 Body mass index; CRC cis rs9291683 0.552 rs10939655 chr4:10014642 A/T cg11266682 chr4:10021025 SLC2A9 0.54 11.57 0.54 3.38e-26 Bone mineral density; CRC cis rs7666738 0.544 rs35160902 chr4:98974690 A/T cg05340658 chr4:99064831 C4orf37 0.59 9.09 0.45 9.58e-18 Colonoscopy-negative controls vs population controls; CRC cis rs9467773 0.526 rs9348710 chr6:26360486 A/C cg14345882 chr6:26364793 BTN3A2 0.4 6.33 0.33 7.96e-10 Intelligence (multi-trait analysis); CRC cis rs1552244 0.554 rs17050705 chr3:10046398 G/C cg08888203 chr3:10149979 C3orf24 0.48 7.32 0.37 1.9e-12 Alzheimer's disease; CRC cis rs1322512 0.677 rs2695251 chr6:152927101 T/C cg03415253 chr6:152958462 SYNE1 -0.4 -6.32 -0.33 8.64e-10 Tonometry; CRC cis rs4731207 0.596 rs6967887 chr7:124609490 G/A cg23710748 chr7:124431027 NA -0.39 -6.25 -0.33 1.29e-9 Cutaneous malignant melanoma; CRC cis rs11608355 0.810 rs12424599 chr12:109866615 A/G cg19025524 chr12:109796872 NA -0.46 -5.88 -0.31 1.02e-8 Neuroticism; CRC cis rs561341 0.882 rs504887 chr17:30322881 T/A cg00745463 chr17:30367425 LRRC37B -0.75 -8.71 -0.43 1.56e-16 Hip circumference adjusted for BMI; CRC cis rs9926296 0.585 rs4785595 chr16:89835521 C/T cg04287289 chr16:89883240 FANCA -0.77 -13.2 -0.59 3.17e-32 Vitiligo; CRC cis rs2549003 0.966 rs2706386 chr5:131832687 C/T cg21138405 chr5:131827807 IRF1 -0.59 -11.64 -0.54 1.9e-26 Asthma (sex interaction); CRC cis rs4975616 0.869 rs370348 chr5:1331219 A/G cg26373071 chr5:1325741 CLPTM1L 0.54 9.79 0.47 5.02e-20 Lung cancer; CRC cis rs1862618 0.671 rs906631 chr5:56245803 C/G cg20203395 chr5:56204925 C5orf35 0.58 8.0 0.4 2.11e-14 Initial pursuit acceleration; CRC cis rs453301 0.653 rs7016139 chr8:8895470 A/G cg06636001 chr8:8085503 FLJ10661 -0.51 -7.54 -0.38 4.75e-13 Joint mobility (Beighton score); CRC cis rs4481887 0.893 rs1339991 chr1:248509363 C/T cg00666640 chr1:248458726 OR2T12 0.48 8.98 0.44 2.14e-17 Common traits (Other); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg08333703 chr19:35225315 ZNF181 0.38 6.52 0.34 2.67e-10 Liver disease severity in Alagille syndrome; CRC cis rs4862750 0.957 rs6858853 chr4:187903412 A/C cg24874828 chr4:187887005 NA 0.34 5.88 0.31 1.01e-8 Lobe attachment (rater-scored or self-reported); CRC cis rs9522267 0.511 rs1163626 chr13:112225200 A/C cg14352298 chr13:112236639 NA 0.29 6.78 0.35 5.66e-11 Hepatitis; CRC cis rs4727027 0.865 rs62505077 chr7:148849656 T/A cg23583168 chr7:148888333 NA -0.93 -16.25 -0.67 5.44e-44 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC cis rs4713118 0.869 rs6902689 chr6:27709441 C/T cg12273811 chr6:28175739 NA 0.55 7.81 0.4 7.59e-14 Parkinson's disease; CRC cis rs7044106 0.708 rs1324472 chr9:123375110 C/T cg09586646 chr9:123605570 PSMD5;LOC253039 0.49 6.93 0.36 2.29e-11 Hip circumference adjusted for BMI; CRC cis rs1707322 0.721 rs28641748 chr1:46212836 A/G cg03146154 chr1:46216737 IPP 0.68 9.94 0.48 1.59e-20 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs172166 0.637 rs1233691 chr6:28153897 T/G cg02683197 chr6:28174875 NA 0.73 10.76 0.51 2.46e-23 Cardiac Troponin-T levels; CRC trans rs2303319 0.504 rs62189055 chr2:162625749 C/A cg12500891 chr11:57225987 NA -0.66 -6.1 -0.32 2.98e-9 Cognitive function; CRC cis rs8031584 0.918 rs34331396 chr15:31248736 C/G cg08704250 chr15:31115839 NA -0.45 -8.25 -0.41 3.73e-15 Huntington's disease progression; CRC cis rs9368481 0.761 rs4713062 chr6:26948195 A/G cg18278486 chr6:26987575 LOC100270746;C6orf41 -0.42 -6.61 -0.34 1.56e-10 Autism spectrum disorder or schizophrenia; CRC cis rs4713118 0.547 rs2116981 chr6:28067951 T/G cg25164649 chr6:28176230 NA 0.75 9.32 0.46 1.72e-18 Parkinson's disease; CRC cis rs1799949 0.931 rs34410138 chr17:41279770 A/G cg19454999 chr17:41278357 BRCA1;NBR2 0.55 8.63 0.43 2.58e-16 Menopause (age at onset); CRC cis rs12971120 0.783 rs7229256 chr18:72169129 T/A cg25817165 chr18:72167213 CNDP2 -0.66 -11.59 -0.54 2.83e-26 Refractive error; CRC cis rs1799949 1.000 rs8176318 chr17:41197274 G/T cg25072359 chr17:41440525 NA 0.43 6.55 0.34 2.26e-10 Menopause (age at onset); CRC cis rs12497850 0.863 rs4858799 chr3:48728204 G/C cg20833759 chr3:49053208 WDR6;DALRD3 0.42 7.23 0.37 3.36e-12 Parkinson's disease; CRC cis rs782590 0.774 rs782629 chr2:55900283 C/T cg18811423 chr2:55921094 PNPT1 -0.8 -14.93 -0.64 7.52e-39 Metabolic syndrome; CRC cis rs9788333 0.888 rs35880230 chr13:21885972 A/G cg06138931 chr13:21896616 NA 0.54 8.48 0.42 7.47e-16 Thiazide-induced adverse metabolic effects in hypertensive patients; CRC cis rs853679 0.517 rs9393884 chr6:28046789 A/G cg06470822 chr6:28175283 NA 0.97 13.12 0.59 6.55e-32 Depression; CRC cis rs875971 1.000 rs875971 chr7:65617595 A/G cg00343986 chr7:65444356 GUSB -0.44 -6.52 -0.34 2.59e-10 Aortic root size; CRC cis rs17767294 0.612 rs12332927 chr6:27955115 T/C cg20358437 chr6:27870759 NA 0.63 6.65 0.34 1.22e-10 Parkinson's disease; CRC cis rs2576037 0.526 rs7234570 chr18:44459656 A/G cg19077165 chr18:44547161 KATNAL2 -0.6 -10.1 -0.49 4.59e-21 Personality dimensions; CRC cis rs1387259 0.899 rs7307566 chr12:48604682 A/G cg04545296 chr12:48745243 ZNF641 0.33 5.9 0.31 9.25e-9 Obstructive sleep apnea trait (apnea hypopnea index); CRC cis rs418053 0.648 rs204226 chr6:13706250 C/G cg02206980 chr6:13574034 SIRT5 0.37 6.05 0.32 3.96e-9 Breast cancer; CRC cis rs734999 0.505 rs4073285 chr1:2539796 C/T cg18854424 chr1:2615690 NA 0.39 7.42 0.38 9.99e-13 Ulcerative colitis; CRC cis rs13161895 1.000 rs394616 chr5:179418134 T/G cg02702477 chr5:179499311 RNF130 0.56 6.46 0.34 3.77e-10 LDL cholesterol; CRC cis rs1832871 0.672 rs12525675 chr6:158708749 A/T cg07165851 chr6:158734300 TULP4 0.62 7.69 0.39 1.69e-13 Height; CRC cis rs6893807 1.000 rs16903275 chr5:87950543 A/C cg09002922 chr5:87956389 LOC645323 0.43 6.3 0.33 9.8e-10 Body mass index; CRC cis rs1552244 0.882 rs13063929 chr3:10010308 T/C cg13047869 chr3:10149882 C3orf24 0.53 7.15 0.37 5.54e-12 Alzheimer's disease; CRC cis rs155076 0.711 rs4770129 chr13:21882059 T/G cg23743428 chr13:21893420 NA -0.39 -5.91 -0.31 8.78e-9 White matter hyperintensity burden; CRC cis rs769267 0.965 rs2315025 chr19:19426609 C/T cg03709012 chr19:19516395 GATAD2A 0.69 10.62 0.51 7.34e-23 Tonsillectomy; CRC trans rs11098499 0.754 rs7672372 chr4:120248406 A/G cg25214090 chr10:38739885 LOC399744 0.52 8.3 0.42 2.78e-15 Corneal astigmatism; CRC cis rs10540 1.000 rs10540 chr11:494662 G/A cg21784768 chr11:537496 LRRC56 -0.68 -6.51 -0.34 2.8e-10 Body mass index; CRC cis rs12681288 0.792 rs4735972 chr8:998618 A/C cg04851639 chr8:1020857 NA -0.28 -5.97 -0.31 6.03e-9 Schizophrenia; CRC cis rs4713118 0.824 rs742046 chr6:27739254 A/G cg12172441 chr6:28176163 NA 0.55 7.12 0.37 6.62e-12 Parkinson's disease; CRC cis rs2762353 0.595 rs12200838 chr6:25753603 C/T cg15691649 chr6:25882328 NA 0.47 6.13 0.32 2.46e-9 Blood metabolite levels; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg03183882 chr3:15373315 SH3BP5 0.44 6.18 0.32 1.94e-9 Response to antipsychotic treatment; CRC cis rs7264396 0.563 rs11906854 chr20:34383634 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.44 -6.33 -0.33 8.12e-10 Total cholesterol levels; CRC cis rs2976388 0.533 rs12543368 chr8:143819450 T/C cg04969067 chr8:143858791 LYNX1 -0.41 -6.15 -0.32 2.21e-9 Urinary tract infection frequency; CRC cis rs10504229 0.639 rs11781834 chr8:58133422 C/T cg04204079 chr8:58130323 NA -0.44 -5.63 -0.3 3.87e-8 Developmental language disorder (linguistic errors); CRC cis rs9818758 0.607 rs55873331 chr3:49597055 C/T cg07636037 chr3:49044803 WDR6 -0.76 -5.7 -0.3 2.6e-8 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; CRC cis rs9361491 0.621 rs12196457 chr6:79627743 A/T cg09184832 chr6:79620586 NA -0.46 -8.03 -0.4 1.72e-14 Intelligence (multi-trait analysis); CRC cis rs11690935 0.688 rs7600835 chr2:172521827 C/T cg13550731 chr2:172543902 DYNC1I2 -0.68 -9.86 -0.48 2.92e-20 Schizophrenia; CRC cis rs9916302 0.752 rs11078895 chr17:37401051 A/G cg07936489 chr17:37558343 FBXL20 -0.88 -11.47 -0.53 7.5e-26 Glomerular filtration rate (creatinine); CRC cis rs11123170 0.529 rs35606997 chr2:113973350 G/A cg11763394 chr2:113992921 PAX8;LOC440839;LOC654433 0.46 5.66 0.3 3.39e-8 Renal function-related traits (BUN); CRC cis rs801193 0.967 rs3800823 chr7:66147110 C/A cg11764359 chr7:65958608 NA -0.53 -8.1 -0.41 1.07e-14 Aortic root size; CRC cis rs6543140 0.964 rs6748390 chr2:103062175 A/G cg03938978 chr2:103052716 IL18RAP 0.45 7.03 0.36 1.2e-11 Blood protein levels; CRC cis rs11098499 0.863 rs2291185 chr4:120434833 C/A cg09307838 chr4:120376055 NA 0.69 10.46 0.5 2.77e-22 Corneal astigmatism; CRC trans rs3118233 1 rs3118233 chr16:68733646 G/C cg04657470 chr2:198365150 HSPE1;HSPD1 -0.86 -12.35 -0.56 4.63e-29 Red cell distribution width; CRC cis rs7826238 0.539 rs2945891 chr8:8155475 C/T cg08975724 chr8:8085496 FLJ10661 0.45 6.92 0.36 2.43e-11 Systolic blood pressure; CRC cis rs2011503 1.000 rs6511031 chr19:19471506 T/C cg11584989 chr19:19387371 SF4 -0.48 -5.8 -0.3 1.55e-8 Bipolar disorder; CRC cis rs727505 0.564 rs4731236 chr7:124827236 G/T cg23710748 chr7:124431027 NA -0.62 -10.31 -0.49 9e-22 Lewy body disease; CRC cis rs13256369 0.901 rs12681298 chr8:8566235 A/G cg06636001 chr8:8085503 FLJ10661 -0.45 -6.03 -0.32 4.32e-9 Obesity-related traits; CRC trans rs4714291 0.698 rs2983144 chr6:40046724 G/A cg02267698 chr19:7991119 CTXN1 -0.45 -6.06 -0.32 3.81e-9 Strep throat; CRC cis rs7811142 0.943 rs11769886 chr7:99998607 G/A cg00814883 chr7:100076585 TSC22D4 -0.78 -9.29 -0.46 2.12e-18 Platelet count; CRC cis rs7605827 0.930 rs11692646 chr2:15559198 C/G cg19274914 chr2:15703543 NA -0.38 -5.93 -0.31 7.65e-9 Educational attainment (years of education); CRC cis rs12188164 0.686 rs72711365 chr5:416672 G/A cg00976097 chr5:421733 AHRR -0.44 -6.02 -0.31 4.69e-9 Cystic fibrosis severity; CRC cis rs941873 0.772 rs2000404 chr10:81109708 T/C cg09469691 chr10:81107165 PPIF 0.52 7.97 0.4 2.58e-14 Height; CRC cis rs8060686 0.920 rs3809630 chr16:67879400 G/A cg01951491 chr16:67709440 GFOD2 -0.52 -5.75 -0.3 2.08e-8 HDL cholesterol;Metabolic syndrome; CRC cis rs2180341 0.961 rs7774468 chr6:127592501 G/C cg27446573 chr6:127587934 RNF146 0.99 14.64 0.63 1.05e-37 Breast cancer; CRC cis rs754466 0.580 rs10762765 chr10:79566407 T/C cg26805224 chr10:79626177 DLG5 -0.46 -6.78 -0.35 5.73e-11 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs2346177 0.519 rs13003074 chr2:46671420 A/T cg26688816 chr2:46740690 ATP6V1E2 0.58 8.91 0.44 3.68e-17 HDL cholesterol; CRC cis rs875971 0.862 rs7782704 chr7:65805366 G/A cg12463550 chr7:65579703 CRCP -0.53 -7.51 -0.38 5.45e-13 Aortic root size; CRC cis rs6424115 0.964 rs2473375 chr1:24136545 C/T cg09473613 chr1:24152604 HMGCL 0.35 5.8 0.3 1.53e-8 Immature fraction of reticulocytes; CRC cis rs4478858 0.735 rs2889730 chr1:31827159 C/T cg00250761 chr1:31883323 NA -0.44 -8.42 -0.42 1.2e-15 Alcohol dependence; CRC cis rs9916302 0.861 rs8079590 chr17:37426201 T/C cg00129232 chr17:37814104 STARD3 -0.54 -8.1 -0.41 1.09e-14 Glomerular filtration rate (creatinine); CRC cis rs12476592 0.602 rs262523 chr2:63892684 T/C cg10828910 chr2:63850056 LOC388955 0.52 6.44 0.33 4.3e-10 Childhood ear infection; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg16037806 chr7:91570105 AKAP9 0.43 6.11 0.32 2.88e-9 Intelligence (multi-trait analysis); CRC cis rs1018836 0.828 rs756568 chr8:91557038 G/C cg16814680 chr8:91681699 NA -0.62 -9.48 -0.46 5.23e-19 Ejection fraction in Tripanosoma cruzi seropositivity; CRC cis rs9443645 0.901 rs9448588 chr6:79590061 T/G cg05283184 chr6:79620031 NA -0.57 -9.21 -0.45 3.98e-18 Intelligence (multi-trait analysis); CRC cis rs17092148 1.000 rs910872 chr20:33334540 T/C cg08999081 chr20:33150536 PIGU 0.46 5.73 0.3 2.24e-8 Neuroticism; CRC cis rs34375054 0.573 rs12579211 chr12:125647752 C/T cg25124228 chr12:125621409 AACS -0.59 -6.73 -0.35 7.72e-11 Post bronchodilator FEV1/FVC ratio; CRC trans rs1997103 1.000 rs6953494 chr7:55412157 G/A cg20935933 chr6:143382018 AIG1 0.51 6.63 0.34 1.35e-10 QRS interval (sulfonylurea treatment interaction); CRC cis rs9368481 0.761 rs12661756 chr6:27003483 A/G cg12292205 chr6:26970375 C6orf41 0.75 12.1 0.55 4.03e-28 Autism spectrum disorder or schizophrenia; CRC trans rs1814175 0.586 rs2866862 chr11:49954588 T/C cg15704280 chr7:45808275 SEPT13 -0.95 -16.95 -0.68 9.06e-47 Height; CRC cis rs10191773 0.522 rs6747639 chr2:112967458 C/T cg24977338 chr2:113188963 RGPD8;RGPD5 -0.64 -5.88 -0.31 9.83e-9 Yeast infection; CRC cis rs728616 0.764 rs56196124 chr10:81902655 A/T cg11900509 chr10:81946545 ANXA11 -0.69 -7.85 -0.4 6.11e-14 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs11764590 0.950 rs11514731 chr7:2051503 C/G cg25834613 chr7:1915315 MAD1L1 -0.44 -6.22 -0.32 1.5e-9 Neuroticism; CRC cis rs6546550 0.935 rs7563062 chr2:70050725 G/A cg02498382 chr2:70120550 SNRNP27 -0.47 -7.77 -0.39 9.81e-14 Prevalent atrial fibrillation; CRC cis rs2421770 0.530 rs2421764 chr11:35364578 A/T cg13971030 chr11:35366721 SLC1A2 -0.39 -6.75 -0.35 6.74e-11 Staphylococcus aureus nasal carriage (persistent); CRC cis rs9487051 0.768 rs399561 chr6:109524979 G/A cg21918786 chr6:109611834 NA -0.33 -5.64 -0.3 3.67e-8 Reticulocyte fraction of red cells; CRC cis rs4474465 1.000 rs2063727 chr11:78183882 T/A cg27205649 chr11:78285834 NARS2 -0.46 -5.6 -0.3 4.5e-8 Alzheimer's disease (survival time); CRC cis rs55823223 0.564 rs4572466 chr17:73846314 A/C cg08125733 chr17:73851984 WBP2 0.75 9.55 0.47 3e-19 Psoriasis; CRC cis rs4363385 0.668 rs6587717 chr1:152984443 G/C cg25856811 chr1:152973957 SPRR3 -0.25 -6.77 -0.35 5.83e-11 Inflammatory skin disease; CRC cis rs832540 0.966 rs252925 chr5:56203773 G/A cg12311346 chr5:56204834 C5orf35 -0.47 -6.96 -0.36 1.86e-11 Coronary artery disease; CRC cis rs2739330 0.828 rs5751770 chr22:24252842 A/G cg23131131 chr22:24373011 LOC391322 -0.66 -10.18 -0.49 2.36e-21 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs10256972 0.721 rs2030959 chr7:1075906 T/C cg07308232 chr7:1071921 C7orf50 -0.51 -7.31 -0.37 2.08e-12 Longevity;Endometriosis; CRC cis rs6061231 1.000 rs6061231 chr20:60956917 C/A cg22601191 chr20:60968625 CABLES2 0.44 7.29 0.37 2.35e-12 Colorectal cancer; CRC cis rs713477 0.967 rs4901570 chr14:55915249 T/C cg13175173 chr14:55914753 NA -0.52 -9.94 -0.48 1.57e-20 Pediatric bone mineral content (femoral neck); CRC cis rs2303745 0.589 rs1465576 chr19:17398487 G/A cg04248312 chr19:17393744 ANKLE1 -0.94 -13.98 -0.61 3.5e-35 Systemic lupus erythematosus; CRC cis rs2243480 1.000 rs313831 chr7:65551226 C/T cg18252515 chr7:66147081 NA -1.13 -13.33 -0.59 1.06e-32 Diabetic kidney disease; CRC cis rs4077515 0.527 rs10870146 chr9:139308054 G/A cg14019695 chr9:139328340 INPP5E 0.37 5.62 0.3 4.11e-8 Ulcerative colitis;IgA nephropathy;Inflammatory bowel disease;Crohn's disease; CRC cis rs7914558 0.505 rs12260436 chr10:104741114 A/C cg04362960 chr10:104952993 NT5C2 0.64 8.75 0.43 1.13e-16 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs3772130 0.775 rs6781857 chr3:121560721 T/C cg20356878 chr3:121714668 ILDR1 0.52 8.2 0.41 5.3e-15 Cognitive performance; CRC cis rs7542091 0.704 rs1883331 chr1:210043483 A/G cg22029157 chr1:209979665 IRF6 0.47 7.4 0.38 1.11e-12 Monobrow; CRC cis rs2228479 0.850 rs2238525 chr16:89809902 T/C cg06558623 chr16:89946397 TCF25 0.95 9.45 0.46 6.77e-19 Skin colour saturation; CRC cis rs4321325 0.546 rs11886766 chr2:127948621 G/A cg11380483 chr2:127933992 NA 0.53 6.7 0.35 8.84e-11 Protein C levels; CRC cis rs7914558 0.966 rs10450373 chr10:104728616 T/C cg04362960 chr10:104952993 NT5C2 0.62 9.39 0.46 1.02e-18 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs2463822 0.687 rs118012228 chr11:62155914 G/A cg06239285 chr11:62104954 ASRGL1 -0.98 -9.95 -0.48 1.42e-20 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs1552244 0.816 rs56387520 chr3:10042782 C/T cg16606324 chr3:10149918 C3orf24 0.62 8.08 0.41 1.25e-14 Alzheimer's disease; CRC cis rs597539 0.652 rs622082 chr11:68703959 A/G cg06112835 chr11:68658793 MRPL21 0.43 6.82 0.35 4.38e-11 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs9715521 0.900 rs6819160 chr4:59834879 A/G cg11281224 chr4:60001000 NA -0.37 -5.63 -0.3 3.96e-8 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs12889267 0.770 rs2319627 chr14:21565189 C/T cg02988727 chr14:21567520 ZNF219;C14orf176 -0.46 -6.81 -0.35 4.7e-11 Hematocrit;Resting heart rate; CRC trans rs800082 0.690 rs800081 chr3:144339980 C/T cg24215973 chr2:240111563 HDAC4 0.62 9.92 0.48 1.79e-20 Smoking behavior; CRC trans rs6550704 0.687 rs9865314 chr3:22634337 A/G cg10251347 chr1:52344305 NRD1 -0.43 -6.53 -0.34 2.54e-10 Daytime sleep phenotypes; CRC trans rs11098499 0.865 rs11722183 chr4:120280597 A/C cg25214090 chr10:38739885 LOC399744 0.6 9.36 0.46 1.25e-18 Corneal astigmatism; CRC cis rs853679 0.517 rs1340004 chr6:28103691 C/T cg23161317 chr6:28129485 ZNF389 0.52 6.36 0.33 6.6e-10 Depression; CRC cis rs10504229 0.609 rs56289889 chr8:58116276 G/C cg22535103 chr8:58192502 C8orf71 -0.7 -9.34 -0.46 1.47e-18 Developmental language disorder (linguistic errors); CRC cis rs3858526 0.959 rs61876223 chr11:5943393 G/A cg26762873 chr11:5879799 OR52E8 -0.41 -5.95 -0.31 6.78e-9 DNA methylation (variation); CRC cis rs9916302 0.706 rs2338799 chr17:37513941 G/A cg00129232 chr17:37814104 STARD3 0.58 7.09 0.36 8.09e-12 Glomerular filtration rate (creatinine); CRC cis rs7772486 0.875 rs10457793 chr6:146415403 A/G cg23711669 chr6:146136114 FBXO30 0.66 11.56 0.54 3.54e-26 Lobe attachment (rater-scored or self-reported); CRC cis rs9807989 0.507 rs6710528 chr2:103016142 A/G cg03938978 chr2:103052716 IL18RAP -0.58 -10.0 -0.48 9.52e-21 Asthma; CRC cis rs77972916 0.611 rs11693190 chr2:43602415 A/T cg06169590 chr2:43455088 ZFP36L2;LOC100129726 -0.52 -6.28 -0.33 1.06e-9 Granulocyte percentage of myeloid white cells; CRC cis rs1532331 0.548 rs6894506 chr5:43169096 C/T cg09164108 chr5:43007320 NA 0.45 7.36 0.38 1.5e-12 Menarche (age at onset); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg25462384 chr19:7985170 SNAPC2 0.39 6.34 0.33 7.56e-10 Liver disease severity in Alagille syndrome; CRC trans rs11039798 0.623 rs6485879 chr11:48587984 G/T cg15704280 chr7:45808275 SEPT13 0.66 6.96 0.36 1.9e-11 Axial length; CRC cis rs7617773 0.539 rs1471217 chr3:48384895 A/C cg11946769 chr3:48343235 NME6 0.61 8.23 0.41 4.33e-15 Coronary artery disease; CRC cis rs812925 0.553 rs1177307 chr2:61387388 T/C cg10580144 chr2:61372316 C2orf74 0.36 8.05 0.41 1.56e-14 Immature fraction of reticulocytes; CRC trans rs1005277 0.579 rs2505194 chr10:38393881 C/T cg27523141 chr10:43048294 ZNF37B 0.48 6.88 0.35 3.06e-11 Extrinsic epigenetic age acceleration; CRC cis rs2880765 0.835 rs7163958 chr15:86045215 G/A cg17133734 chr15:86042851 AKAP13 0.42 6.76 0.35 6.41e-11 Coronary artery disease; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg12589749 chr1:54304061 TMEM48 0.46 6.4 0.33 5.51e-10 Response to antipsychotic treatment; CRC cis rs10927875 0.541 rs1739841 chr1:16342727 A/G cg24140574 chr1:16342155 HSPB7 0.47 6.74 0.35 7.16e-11 Dilated cardiomyopathy; CRC cis rs1997103 1.000 rs6945937 chr7:55407140 C/T cg17469321 chr7:55412551 NA 0.72 11.28 0.53 3.48e-25 QRS interval (sulfonylurea treatment interaction); CRC cis rs9926296 0.581 rs6500457 chr16:89898764 C/G cg04287289 chr16:89883240 FANCA -0.6 -9.57 -0.47 2.75e-19 Vitiligo; CRC cis rs875971 0.862 rs1167390 chr7:65575893 G/A cg18876405 chr7:65276391 NA -0.51 -8.54 -0.43 4.92e-16 Aortic root size; CRC cis rs1018836 0.851 rs12548741 chr8:91628878 G/A cg16814680 chr8:91681699 NA -0.77 -12.18 -0.56 1.96e-28 Ejection fraction in Tripanosoma cruzi seropositivity; CRC cis rs1552244 1.000 rs113153120 chr3:10156398 G/A cg08888203 chr3:10149979 C3orf24 0.7 9.38 0.46 1.14e-18 Alzheimer's disease; CRC cis rs61996546 0.622 rs12905999 chr15:26867460 A/G cg15066197 chr15:26874202 GABRB3 -0.39 -5.99 -0.31 5.37e-9 Response to methotrexate in juvenile idiopathic arthritis; CRC cis rs55788414 0.932 rs12103358 chr16:81185844 C/G cg06400318 chr16:81190750 PKD1L2 -0.57 -6.7 -0.35 9.14e-11 Left ventricular obstructive tract defect (maternal effect); CRC cis rs916888 0.821 rs199507 chr17:44858855 A/G cg01570182 chr17:44337453 NA -1.07 -12.8 -0.58 9.93e-31 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs270601 0.710 rs371709 chr5:131583240 A/G cg18758796 chr5:131593413 PDLIM4 0.5 8.44 0.42 1.05e-15 Acylcarnitine levels; CRC cis rs4665809 1.000 rs4665821 chr2:26309949 A/C cg25036284 chr2:26402008 FAM59B -0.46 -6.04 -0.32 4.12e-9 Gut microbiome composition (summer); CRC cis rs9926296 0.585 rs6500450 chr16:89858024 A/G cg21285383 chr16:89894308 SPIRE2 0.35 5.84 0.31 1.25e-8 Vitiligo; CRC cis rs9487051 0.872 rs1521908 chr6:109613986 T/C cg01475377 chr6:109611718 NA -0.48 -9.03 -0.45 1.51e-17 Reticulocyte fraction of red cells; CRC cis rs270601 0.837 rs367805 chr5:131701279 T/C cg22638593 chr5:131593259 PDLIM4 0.38 6.35 0.33 6.97e-10 Acylcarnitine levels; CRC cis rs4728302 0.869 rs12707128 chr7:133589796 A/G cg03336402 chr7:133662267 EXOC4 -0.49 -7.06 -0.36 9.68e-12 Intelligence;Intelligence (multi-trait analysis); CRC cis rs514406 0.861 rs35581164 chr1:53271373 C/G cg27535305 chr1:53392650 SCP2 -0.35 -6.22 -0.32 1.53e-9 Monocyte count; CRC cis rs7119 0.651 rs12917044 chr15:77850146 A/G cg10437265 chr15:77819839 NA -0.58 -10.24 -0.49 1.49e-21 Type 2 diabetes; CRC cis rs12050794 0.671 rs7179427 chr15:72516821 G/A cg16672083 chr15:72433130 SENP8 0.41 6.33 0.33 7.87e-10 Metabolite levels (HVA/MHPG ratio); CRC cis rs4481887 1.000 rs6663817 chr1:248495613 A/G cg00666640 chr1:248458726 OR2T12 0.55 9.4 0.46 9.61e-19 Common traits (Other); CRC cis rs9902453 0.967 rs12150261 chr17:28320473 A/C cg26525008 chr17:28256777 EFCAB5;SSH2 -0.57 -8.69 -0.43 1.8e-16 Coffee consumption (cups per day); CRC cis rs4819052 0.851 rs9974628 chr21:46672647 C/T cg19498844 chr21:46707878 POFUT2;LOC642852 0.75 11.0 0.52 3.46e-24 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs4660306 0.961 rs4660862 chr1:45955056 C/T cg03123370 chr1:45965343 CCDC163P;MMACHC -0.56 -7.85 -0.4 5.99e-14 Homocysteine levels; CRC cis rs250677 1.000 rs36069 chr5:148417253 G/C cg23229984 chr5:148520753 ABLIM3 0.47 6.69 0.35 9.6e-11 Breast cancer; CRC cis rs13118159 0.742 rs7679860 chr4:1333987 C/T cg02018176 chr4:1364513 KIAA1530 0.44 6.98 0.36 1.64e-11 Longevity; CRC cis rs11809207 0.523 rs2802343 chr1:26498570 T/C cg00147160 chr1:26503991 CNKSR1 0.29 6.07 0.32 3.56e-9 Height; CRC cis rs9768139 0.935 rs6953748 chr7:158121184 G/A cg24154853 chr7:158122151 PTPRN2 -0.6 -10.04 -0.48 6.97e-21 Calcium levels; CRC cis rs57994353 0.897 rs3812595 chr9:139369062 C/T cg14119001 chr9:139324193 INPP5E -0.44 -6.2 -0.32 1.65e-9 Eosinophil counts;Cutaneous squamous cell carcinoma; CRC cis rs473651 0.692 rs579511 chr2:239334914 C/G cg21699342 chr2:239360505 ASB1 0.53 9.42 0.46 7.96e-19 Multiple system atrophy; CRC cis rs1218582 0.772 rs11264290 chr1:154912300 C/T cg24250549 chr1:154909240 PMVK 0.64 10.86 0.51 1.07e-23 Prostate cancer; CRC cis rs2836974 0.899 rs34176878 chr21:40548855 C/A cg11890956 chr21:40555474 PSMG1 1.08 18.2 0.71 1.07e-51 Cognitive function; CRC cis rs28829049 0.597 rs12566296 chr1:19498443 A/C cg13387374 chr1:19411106 UBR4 0.41 6.06 0.32 3.81e-9 QRS duration in Tripanosoma cruzi seropositivity; CRC cis rs7772486 0.641 rs2748489 chr6:146331287 T/G cg23711669 chr6:146136114 FBXO30 0.57 8.09 0.41 1.18e-14 Lobe attachment (rater-scored or self-reported); CRC cis rs9322193 0.851 rs9322194 chr6:149920249 C/T cg05861140 chr6:150128134 PCMT1 -0.36 -5.74 -0.3 2.16e-8 Lung cancer; CRC cis rs12681287 0.640 rs61106663 chr8:87477081 G/C cg27223183 chr8:87520930 FAM82B -0.53 -7.52 -0.38 5.31e-13 Caudate activity during reward; CRC cis rs9527 0.614 rs4919691 chr10:104624475 A/C cg15744005 chr10:104629667 AS3MT -0.36 -7.06 -0.36 1.01e-11 Arsenic metabolism; CRC cis rs9443645 0.901 rs13191068 chr6:79714867 T/C cg11833968 chr6:79620685 NA -0.36 -6.11 -0.32 2.78e-9 Intelligence (multi-trait analysis); CRC cis rs4665809 0.549 rs72809635 chr2:26411674 G/A cg26119090 chr2:26468346 HADHA;HADHB 0.97 11.86 0.55 2.94e-27 Gut microbiome composition (summer); CRC cis rs6674176 0.597 rs3762422 chr1:44400532 T/A cg13606994 chr1:44402422 ARTN -0.39 -6.57 -0.34 1.94e-10 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Cognitive ability; CRC trans rs1578862 0.872 rs1778550 chr1:247431329 C/T cg06850283 chr5:44389769 FGF10 -0.25 -6.23 -0.32 1.46e-9 Monocyte percentage of white cells; CRC cis rs2204008 0.777 rs11179774 chr12:38219559 A/C cg26384229 chr12:38710491 ALG10B 0.68 9.03 0.45 1.49e-17 Bladder cancer; CRC cis rs1868673 1.000 rs4681619 chr3:150160253 G/A cg04908077 chr3:150187338 NA -0.33 -5.64 -0.3 3.58e-8 Waist circumference; CRC cis rs10504229 0.683 rs72649192 chr8:58110490 T/C cg24829409 chr8:58192753 C8orf71 -0.61 -7.77 -0.39 9.9e-14 Developmental language disorder (linguistic errors); CRC cis rs3740540 0.507 rs942015 chr10:126289932 G/T cg04949429 chr10:126290192 LHPP 0.43 6.37 0.33 6.47e-10 Obesity-related traits;Acute lymphoblastic leukemia (childhood); CRC cis rs2969070 1.000 rs2895171 chr7:2514209 G/A cg03277898 chr7:2518824 NA -0.45 -6.63 -0.34 1.4e-10 Diastolic blood pressure; CRC cis rs9291683 0.655 rs55941493 chr4:10100341 G/A cg00071950 chr4:10020882 SLC2A9 -0.48 -8.33 -0.42 2.21e-15 Bone mineral density; CRC cis rs9291683 0.620 rs11722946 chr4:10125990 A/G cg11266682 chr4:10021025 SLC2A9 -0.44 -8.65 -0.43 2.33e-16 Bone mineral density; CRC cis rs11628318 0.539 rs57749886 chr14:103095652 C/T cg12046867 chr14:103022105 NA -0.43 -6.24 -0.33 1.32e-9 Platelet count; CRC cis rs875971 0.545 rs2420612 chr7:66001812 G/A cg05627663 chr7:65219948 SNORA22;CCT6P1 0.61 7.8 0.39 8.52e-14 Aortic root size; CRC cis rs9911578 0.967 rs6503890 chr17:57064167 A/G cg05425664 chr17:57184151 TRIM37 -0.51 -7.93 -0.4 3.56e-14 Intelligence (multi-trait analysis); CRC trans rs7944735 0.832 rs7130876 chr11:48050995 A/G cg15704280 chr7:45808275 SEPT13 0.6 6.41 0.33 5.19e-10 Intraocular pressure; CRC cis rs11785693 0.817 rs62491199 chr8:4997878 G/A cg26367366 chr8:4980734 NA 0.79 9.61 0.47 1.96e-19 Neuroticism (multi-trait analysis);Neuroticism; CRC cis rs17345786 0.906 rs11708616 chr3:101231731 C/T cg12386194 chr3:101231763 SENP7 0.54 7.14 0.37 5.91e-12 Colonoscopy-negative controls vs population controls; CRC cis rs4478858 0.746 rs10798831 chr1:31688385 A/C cg00250761 chr1:31883323 NA 0.31 5.82 0.31 1.42e-8 Alcohol dependence; CRC cis rs1475911 0.744 rs12481958 chr21:43517269 A/G cg14562523 chr21:43528734 C21orf128;UMODL1 -0.47 -6.97 -0.36 1.73e-11 IgG glycosylation; CRC cis rs12200560 0.505 rs211178 chr6:97074094 T/A cg06623918 chr6:96969491 KIAA0776 0.52 7.7 0.39 1.63e-13 Coronary heart disease; CRC cis rs35264875 1.000 rs7110274 chr11:68842704 A/G cg01993067 chr11:68851601 TPCN2 0.56 6.32 0.33 8.39e-10 Blond vs. brown hair color; CRC cis rs6460942 0.630 rs1866650 chr7:12396897 C/T cg20607287 chr7:12443886 VWDE -0.55 -5.93 -0.31 7.55e-9 Coronary artery disease; CRC cis rs6860806 0.661 rs2171247 chr5:131580234 G/T cg18301423 chr5:131593218 PDLIM4 0.37 6.78 0.35 5.43e-11 Breast cancer; CRC cis rs796364 0.951 rs72932280 chr2:200996851 G/C cg25936922 chr2:200820526 C2orf60;C2orf47 -0.67 -7.4 -0.38 1.12e-12 Schizophrenia; CRC cis rs2645694 0.532 rs2645706 chr4:77829606 A/C cg18351406 chr4:77819688 ANKRD56 0.49 7.31 0.37 2.02e-12 Emphysema distribution in smoking; CRC cis rs1564271 0.553 rs9334138 chr10:26978929 G/A cg24343755 chr10:26987087 PDSS1 -0.52 -6.86 -0.35 3.33e-11 Overall survival in serous epithelial ovarian cancer treated with paclitaxel and cisplatin; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg13950403 chr5:153418565 MFAP3;FAM114A2 -0.4 -6.31 -0.33 9.04e-10 Myopia (pathological); CRC cis rs12188164 0.515 rs11745246 chr5:410943 A/G cg26850624 chr5:429559 AHRR -0.71 -11.21 -0.53 6.2e-25 Cystic fibrosis severity; CRC cis rs2213920 0.679 rs10759780 chr9:118196088 A/C cg13918206 chr9:118159781 DEC1 0.61 5.91 0.31 8.52e-9 Docetaxel-induced peripheral neuropathy in metastatic castrate-resistant prostate cancer; CRC cis rs11628318 0.614 rs7145737 chr14:103121784 T/A cg08075719 chr14:103021372 NA 0.65 7.6 0.39 3.13e-13 Platelet count; CRC cis rs6681460 1.000 rs4655647 chr1:67106077 C/G cg02459107 chr1:67143332 SGIP1 0.45 7.67 0.39 2.01e-13 Presence of antiphospholipid antibodies; CRC cis rs10504229 0.683 rs1495866 chr8:58141128 T/C cg21724239 chr8:58056113 NA 0.49 6.81 0.35 4.75e-11 Developmental language disorder (linguistic errors); CRC cis rs9837602 1.000 rs9833980 chr3:99767096 A/G cg07805332 chr3:99536008 MIR548G;C3orf26 -0.48 -6.33 -0.33 8.13e-10 Breast cancer; CRC cis rs870825 0.616 rs4615214 chr4:185624129 G/C cg04058563 chr4:185651563 MLF1IP 0.72 9.38 0.46 1.12e-18 Blood protein levels; CRC cis rs79349575 0.716 rs46522 chr17:46988597 C/T cg22482690 chr17:47019901 SNF8 0.51 8.18 0.41 6.24e-15 Type 2 diabetes; CRC cis rs4713118 0.699 rs573179 chr6:27849676 C/A cg15786705 chr6:28176104 NA 0.54 6.81 0.35 4.58e-11 Parkinson's disease; CRC cis rs12477438 0.798 rs1530996 chr2:99584079 T/C cg14399236 chr2:99771627 LIPT1;TSGA10 -0.71 -9.93 -0.48 1.71e-20 Chronic sinus infection; CRC cis rs8031584 0.678 rs36047941 chr15:31159235 A/G cg08704250 chr15:31115839 NA -0.56 -9.87 -0.48 2.78e-20 Huntington's disease progression; CRC cis rs1150668 0.835 rs1233696 chr6:28143010 T/C cg10876282 chr6:28092338 ZSCAN16 0.4 5.7 0.3 2.67e-8 Pubertal anthropometrics; CRC cis rs877282 0.891 rs12357999 chr10:796468 A/C cg06581033 chr10:766294 NA -0.51 -5.68 -0.3 2.97e-8 Uric acid levels; CRC cis rs7666738 0.830 rs1456208 chr4:98678563 C/T cg17366294 chr4:99064904 C4orf37 0.35 5.7 0.3 2.66e-8 Colonoscopy-negative controls vs population controls; CRC trans rs1455244 0.700 rs7229302 chr18:11508904 G/T cg16892046 chr8:119124311 EXT1 0.39 6.18 0.32 1.88e-9 Schizophrenia; CRC cis rs734999 0.545 rs7368105 chr1:2556548 C/T cg18854424 chr1:2615690 NA 0.4 7.53 0.38 4.77e-13 Ulcerative colitis; CRC cis rs10911232 0.507 rs10797817 chr1:182999136 G/T ch.1.3577855R chr1:183094577 LAMC1 0.86 15.15 0.64 1.1e-39 Hypertriglyceridemia; CRC cis rs11971779 0.625 rs2355784 chr7:139072493 G/T cg07862535 chr7:139043722 LUC7L2 0.57 7.35 0.38 1.61e-12 Diisocyanate-induced asthma; CRC cis rs801193 0.569 rs6951302 chr7:66132512 T/C cg12463550 chr7:65579703 CRCP -0.46 -6.16 -0.32 2.1e-9 Aortic root size; CRC cis rs11997175 0.646 rs61693382 chr8:33697255 A/C cg04338863 chr8:33670619 NA 0.42 6.72 0.35 8.03e-11 Body mass index; CRC cis rs1153858 1.000 rs1365610 chr15:45694610 C/T cg10760299 chr15:45669010 GATM 0.52 7.86 0.4 5.56e-14 Homoarginine levels; CRC cis rs801193 0.569 rs7800620 chr7:66223688 T/C cg11764359 chr7:65958608 NA 0.58 8.72 0.43 1.44e-16 Aortic root size; CRC cis rs2404602 0.647 rs4886837 chr15:77156417 A/G cg23625390 chr15:77176239 SCAPER -0.88 -14.23 -0.62 4e-36 Blood metabolite levels; CRC trans rs2383876 0.550 rs13252291 chr8:74068483 A/G cg23880589 chr17:7826623 KCNAB3 -0.37 -6.17 -0.32 2e-9 Corneal curvature; CRC cis rs7107174 1.000 rs2512542 chr11:77981780 G/A cg02023728 chr11:77925099 USP35 0.49 8.38 0.42 1.59e-15 Testicular germ cell tumor; CRC cis rs12681288 0.676 rs4565481 chr8:1001944 C/T cg08648136 chr8:956695 NA 0.32 5.83 0.31 1.34e-8 Schizophrenia; CRC trans rs12940923 1.000 rs11867689 chr17:56370355 G/C cg16900910 chr15:72789182 ARIH1 0.52 5.97 0.31 6.14e-9 Circulating myeloperoxidase levels (plasma); CRC cis rs10464366 0.544 rs34866559 chr7:39166071 G/A cg15212455 chr7:39170539 POU6F2 0.5 6.65 0.34 1.21e-10 IgG glycosylation; CRC cis rs17376456 0.877 rs13165147 chr5:93422214 G/A cg09848695 chr5:92956644 FAM172A;MIR2277 0.63 5.84 0.31 1.28e-8 Diabetic retinopathy; CRC cis rs941764 1.000 rs941764 chr14:91841069 C/T cg10511902 chr14:91842949 CCDC88C -0.54 -8.88 -0.44 4.55e-17 Breast cancer; CRC cis rs10256972 0.552 rs2960831 chr7:1201192 A/T cg03188948 chr7:1209495 NA 0.59 8.96 0.44 2.49e-17 Longevity;Endometriosis; CRC cis rs9611565 0.649 rs139559 chr22:42191636 A/G cg03806693 chr22:41940476 POLR3H -0.72 -9.98 -0.48 1.14e-20 Vitiligo; CRC cis rs909341 0.710 rs2297433 chr20:62293460 T/C cg16989086 chr20:62203971 PRIC285 -0.5 -6.38 -0.33 6.07e-10 Atopic dermatitis; CRC cis rs6860806 0.507 rs270608 chr5:131648406 C/T cg24060327 chr5:131705240 SLC22A5 -0.51 -7.42 -0.38 9.95e-13 Breast cancer; CRC cis rs117623576 0.618 rs211416 chr10:32397591 T/A cg03047570 chr10:32398778 NA 0.69 7.78 0.39 9.43e-14 Anti-saccade response; CRC cis rs7623687 0.579 rs73082331 chr3:48994943 G/A cg19401529 chr3:49056140 DALRD3 0.67 7.05 0.36 1.04e-11 Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease);Coronary artery disease; CRC cis rs3093024 0.904 rs3093019 chr6:167539655 C/G cg19688584 chr6:167529678 CCR6 -0.32 -5.94 -0.31 7.23e-9 Rheumatoid arthritis; CRC trans rs587242 1.000 rs60507779 chr1:96914875 C/A cg10631902 chr5:14652156 NA 0.44 6.9 0.36 2.62e-11 Body mass index (joint analysis main effects and physical activity interaction);Body mass index in physically inactive individuals;Body mass index; CRC cis rs4927850 0.752 rs7624460 chr3:195748530 C/T cg01181863 chr3:195395398 SDHAP2 -0.67 -9.83 -0.48 3.67e-20 Pancreatic cancer; CRC cis rs425277 0.538 rs169037 chr1:2095582 G/T cg21194808 chr1:2205498 SKI 0.37 5.63 0.3 3.82e-8 Height; CRC cis rs9549328 0.800 rs9549326 chr13:113630453 C/T cg25790453 chr13:113633590 MCF2L -0.57 -10.07 -0.49 5.87e-21 Systolic blood pressure; CRC cis rs853679 0.517 rs3823180 chr6:28061744 G/A cg12273811 chr6:28175739 NA 0.74 9.41 0.46 8.58e-19 Depression; CRC cis rs1008375 1.000 rs7688682 chr4:17693794 A/G cg16339924 chr4:17578868 LAP3 -0.47 -6.39 -0.33 5.82e-10 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs7615952 0.641 rs4422257 chr3:125774363 A/G cg04553112 chr3:125709451 NA -0.51 -5.89 -0.31 9.55e-9 Blood pressure (smoking interaction); CRC cis rs977987 0.835 rs8057535 chr16:75347941 C/T cg03315344 chr16:75512273 CHST6 0.52 8.8 0.44 7.76e-17 Dupuytren's disease; CRC cis rs1799949 0.965 rs9646413 chr17:41426157 A/G cg07153921 chr17:41440717 NA -0.4 -5.97 -0.31 6.2e-9 Menopause (age at onset); CRC cis rs9926296 0.533 rs12102290 chr16:89812617 C/T cg21285383 chr16:89894308 SPIRE2 0.34 5.64 0.3 3.73e-8 Vitiligo; CRC cis rs2953174 0.786 rs8662 chr2:241517770 G/A cg07929629 chr2:241523174 NA 0.53 6.43 0.33 4.39e-10 Bipolar disorder; CRC cis rs11098499 0.954 rs13151285 chr4:120314741 C/A cg24375607 chr4:120327624 NA 0.51 7.86 0.4 5.5e-14 Corneal astigmatism; CRC cis rs9611565 1.000 rs5758314 chr22:41762523 T/G cg06634786 chr22:41940651 POLR3H -0.46 -6.16 -0.32 2.08e-9 Vitiligo; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg01301935 chr16:69599904 NFAT5;MIR1538 0.47 6.86 0.35 3.34e-11 Intelligence (multi-trait analysis); CRC cis rs7937682 0.889 rs564086 chr11:111501079 C/G cg09085632 chr11:111637200 PPP2R1B -0.99 -19.33 -0.73 3.65e-56 Primary sclerosing cholangitis; CRC cis rs9488822 0.636 rs7745074 chr6:116347432 G/A cg18764771 chr6:116381957 FRK 0.25 6.97 0.36 1.74e-11 Cholesterol, total;LDL cholesterol; CRC cis rs11098499 0.954 rs1480931 chr4:120395809 G/T cg24375607 chr4:120327624 NA 0.52 8.21 0.41 5.13e-15 Corneal astigmatism; CRC cis rs2811415 0.597 rs1007233 chr3:127801776 G/T cg13719885 chr3:127795394 NA -0.39 -5.85 -0.31 1.17e-8 Lung function (FEV1/FVC); CRC cis rs1891275 0.515 rs7098763 chr10:93444827 C/T cg07889827 chr10:93443413 NA -0.39 -6.78 -0.35 5.48e-11 Intelligence (multi-trait analysis); CRC cis rs12701220 0.522 rs1881116 chr7:1053958 C/T cg26769984 chr7:1090371 C7orf50 0.47 7.27 0.37 2.57e-12 Bronchopulmonary dysplasia; CRC trans rs1814175 0.817 rs7950856 chr11:49976394 C/T cg11707556 chr5:10655725 ANKRD33B -0.44 -8.34 -0.42 2.03e-15 Height; CRC cis rs10791097 0.667 rs2155358 chr11:130740357 T/C cg12179176 chr11:130786555 SNX19 0.75 12.76 0.58 1.4e-30 Autism spectrum disorder or schizophrenia;Schizophrenia; CRC cis rs904251 0.523 rs2776871 chr6:37481759 A/G cg01843034 chr6:37503916 NA -0.44 -8.24 -0.41 4.06e-15 Cognitive performance; CRC cis rs9914988 0.943 rs28847895 chr17:27172520 T/C cg12682573 chr17:27188876 MIR451;MIR144 0.59 8.47 0.42 8.5e-16 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs6940638 0.744 rs858964 chr6:27142614 C/G cg12292205 chr6:26970375 C6orf41 0.5 7.34 0.38 1.63e-12 Intelligence (multi-trait analysis); CRC trans rs3780486 0.846 rs2209948 chr9:33138247 G/A cg20290983 chr6:43655470 MRPS18A 1.17 24.99 0.81 5.35e-78 IgG glycosylation; CRC cis rs10256972 0.504 rs2949178 chr7:1209925 T/C cg18765753 chr7:1198926 ZFAND2A -0.52 -9.55 -0.47 3.19e-19 Longevity;Endometriosis; CRC cis rs7659604 0.517 rs56311153 chr4:122729685 T/C cg20573242 chr4:122745356 CCNA2 0.57 8.32 0.42 2.37e-15 Type 2 diabetes; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg00713605 chr2:232063387 ARMC9 0.48 6.58 0.34 1.81e-10 Anxiety disorder; CRC cis rs4481887 1.000 rs10888360 chr1:248479282 G/A cg00666640 chr1:248458726 OR2T12 0.53 9.2 0.45 4.29e-18 Common traits (Other); CRC cis rs1712517 0.771 rs11191666 chr10:105127278 A/G cg05636881 chr10:105038444 INA 0.46 7.91 0.4 4.04e-14 Migraine; CRC cis rs2832191 0.716 rs1888440 chr21:30454484 C/T cg08807101 chr21:30365312 RNF160 0.71 11.59 0.54 2.84e-26 Dental caries; CRC cis rs1881797 1.000 rs1881796 chr1:247688931 G/A cg05639522 chr1:247681581 NA 0.47 7.14 0.37 5.95e-12 Acute lymphoblastic leukemia (childhood); CRC trans rs7618501 0.699 rs2777888 chr3:49898000 A/G cg21659725 chr3:3221576 CRBN 0.68 10.66 0.51 5.61e-23 Intelligence (multi-trait analysis); CRC cis rs4944092 0.960 rs10400322 chr11:75910913 C/T cg04588336 chr11:75916460 WNT11 0.38 5.78 0.3 1.69e-8 PR interval; CRC cis rs6500602 0.648 rs7702 chr16:4560929 G/C cg06139259 chr16:4526053 HMOX2;NMRAL1 0.52 6.81 0.35 4.53e-11 Schizophrenia; CRC cis rs877282 0.945 rs34367686 chr10:791868 G/C cg06581033 chr10:766294 NA -0.51 -5.68 -0.3 2.97e-8 Uric acid levels; CRC cis rs2153535 0.580 rs6597325 chr6:8461053 A/C cg07606381 chr6:8435919 SLC35B3 0.68 10.91 0.52 7.65e-24 Motion sickness; CRC cis rs2439831 0.681 rs3742971 chr15:43622916 A/G cg02155558 chr15:43621948 ADAL;LCMT2 -0.69 -8.74 -0.43 1.23e-16 Lung cancer in ever smokers; CRC cis rs290268 0.502 rs1333633 chr9:93567572 G/A cg02608019 chr9:93564028 SYK 0.47 7.29 0.37 2.3e-12 Platelet count; CRC cis rs9649465 1.000 rs1506635 chr7:123317184 C/T cg03229431 chr7:123269106 ASB15 -0.36 -5.64 -0.3 3.69e-8 Migraine; CRC cis rs9534288 0.762 rs9534292 chr13:46611340 T/C cg15192986 chr13:46630673 CPB2 -0.68 -9.89 -0.48 2.31e-20 Blood protein levels; CRC cis rs116095464 0.558 rs10076655 chr5:239464 G/C cg22857025 chr5:266934 NA -1.25 -16.75 -0.68 5.7e-46 Breast cancer; CRC trans rs9354308 0.933 rs2814134 chr6:66566658 C/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.48 6.06 0.32 3.69e-9 Metabolite levels; CRC cis rs208520 1.000 rs12195505 chr6:66986279 T/A cg07460842 chr6:66804631 NA 0.91 11.17 0.52 8.75e-25 Exhaled nitric oxide output; CRC cis rs1559088 0.847 rs8100392 chr19:33605933 T/C cg27124370 chr19:33622961 WDR88 0.44 6.07 0.32 3.48e-9 Bone ultrasound measurement (broadband ultrasound attenuation); CRC cis rs7647973 0.925 rs4955421 chr3:49218888 G/A cg07690219 chr3:49449608 TCTA;RHOA -0.51 -5.93 -0.31 7.74e-9 Menarche (age at onset); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg00446684 chr2:64371646 PELI1 0.44 6.04 0.32 4.12e-9 Response to antipsychotic treatment; CRC cis rs9311676 0.656 rs62258128 chr3:58397142 C/G cg06643156 chr3:58380774 PXK 0.42 6.38 0.33 5.84e-10 Systemic lupus erythematosus; CRC cis rs4819052 0.851 rs13047104 chr21:46673562 T/G cg11663144 chr21:46675770 NA -0.86 -14.97 -0.64 5.18e-39 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs3741404 0.560 rs7938819 chr11:63910116 G/A cg06219103 chr11:63990595 FERMT3 0.44 6.98 0.36 1.61e-11 Platelet count; CRC cis rs7811142 0.830 rs1063945 chr7:99930447 C/T cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.89 11.64 0.54 1.83e-26 Platelet count; CRC cis rs919433 0.929 rs1366836 chr2:198172148 T/G cg10820045 chr2:198174542 NA -0.57 -11.53 -0.54 4.75e-26 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC cis rs12826942 0.605 rs7975932 chr12:42517967 G/A cg11827402 chr12:42719852 PPHLN1;ZCRB1 0.58 6.19 0.32 1.78e-9 Coronary artery disease; CRC trans rs1455244 0.700 rs7229302 chr18:11508904 G/T cg01711073 chr1:37980396 MEAF6 0.38 6.01 0.31 5e-9 Schizophrenia; CRC cis rs200986 1 rs200986 chr6:27824766 G/C cg03623178 chr6:28175578 NA 0.74 10.57 0.5 1.15e-22 Autism spectrum disorder or schizophrenia; CRC cis rs10461617 0.617 rs1423623 chr5:56065575 A/G cg18230493 chr5:56204884 C5orf35 0.41 5.64 0.3 3.65e-8 Type 2 diabetes; CRC cis rs155076 0.711 rs4769158 chr13:21881975 T/C cg21970626 chr13:21893289 NA -0.44 -6.59 -0.34 1.8e-10 White matter hyperintensity burden; CRC cis rs7727544 0.584 rs7714191 chr5:131341541 C/G cg18758796 chr5:131593413 PDLIM4 0.34 5.97 0.31 6.14e-9 Blood metabolite levels; CRC cis rs1552244 1.000 rs3846177 chr3:10068572 G/T cg16606324 chr3:10149918 C3orf24 0.69 9.43 0.46 7.91e-19 Alzheimer's disease; CRC cis rs9902453 0.780 rs57037139 chr17:28173283 C/T cg26525008 chr17:28256777 EFCAB5;SSH2 0.58 8.63 0.43 2.65e-16 Coffee consumption (cups per day); CRC trans rs7618501 0.602 rs2071206 chr3:50160109 G/A cg21665057 chr3:196295764 WDR53;FBXO45 -0.58 -9.28 -0.46 2.38e-18 Intelligence (multi-trait analysis); CRC cis rs875971 0.545 rs66594357 chr7:65792784 G/A cg03233332 chr7:66118400 NA -0.44 -6.23 -0.33 1.39e-9 Aortic root size; CRC cis rs12594515 0.591 rs35554150 chr15:45990298 G/A cg01629716 chr15:45996671 NA 0.4 6.64 0.34 1.32e-10 Waist circumference;Weight; CRC cis rs9443645 0.869 rs9443626 chr6:79629564 G/C cg05283184 chr6:79620031 NA -0.56 -8.84 -0.44 5.83e-17 Intelligence (multi-trait analysis); CRC cis rs9322193 0.962 rs9688809 chr6:150109056 C/T cg13206674 chr6:150067644 NUP43 0.57 8.14 0.41 8.29e-15 Lung cancer; CRC cis rs7772486 0.727 rs2235481 chr6:146056848 T/C cg13319975 chr6:146136371 FBXO30 0.63 9.16 0.45 5.61e-18 Lobe attachment (rater-scored or self-reported); CRC cis rs6922632 0.867 rs62400307 chr6:24114249 C/A cg26194775 chr6:24126114 NRSN1 -0.62 -7.23 -0.37 3.37e-12 Information processing speed; CRC cis rs780096 0.526 rs780112 chr2:27665361 C/G cg02592271 chr2:27665507 KRTCAP3 -0.29 -6.69 -0.35 9.63e-11 Total body bone mineral density; CRC cis rs6700896 0.864 rs56274111 chr1:66128511 A/C cg04111102 chr1:66153794 NA 0.35 6.1 0.32 3.03e-9 C-reactive protein;Mean corpuscular volume;Mean corpuscular hemoglobin; CRC cis rs7113874 0.550 rs11042002 chr11:8616646 T/C cg20771178 chr11:8615675 STK33 0.35 5.77 0.3 1.81e-8 Body mass index in physically active individuals;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs10979 0.546 rs9496686 chr6:143908735 G/C cg25407410 chr6:143891975 LOC285740 -0.66 -8.88 -0.44 4.56e-17 Hypospadias; CRC cis rs7511006 0.893 rs2038049 chr22:50654888 G/C cg16473166 chr22:50639996 SELO 0.58 8.85 0.44 5.46e-17 Obesity-related traits; CRC cis rs7208859 0.623 rs55724095 chr17:29153058 A/G cg01831904 chr17:28903510 LRRC37B2 -0.62 -6.5 -0.34 2.9e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs4713118 0.662 rs9380046 chr6:28030499 T/C cg02683197 chr6:28174875 NA 0.75 9.67 0.47 1.28e-19 Parkinson's disease; CRC cis rs11252926 0.673 rs7096559 chr10:499188 C/T cg18196295 chr10:418757 DIP2C 0.52 7.98 0.4 2.52e-14 Psychosis in Alzheimer's disease; CRC trans rs3780486 1.000 rs10813957 chr9:33153527 G/T cg04842962 chr6:43655489 MRPS18A 1.01 15.81 0.66 2.82e-42 IgG glycosylation; CRC cis rs2576037 0.526 rs7234570 chr18:44459656 A/G cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.65 -10.71 -0.51 3.71e-23 Personality dimensions; CRC cis rs172166 0.694 rs1770131 chr6:28086413 C/T cg12172441 chr6:28176163 NA 0.53 7.17 0.37 5.02e-12 Cardiac Troponin-T levels; CRC cis rs7666738 0.715 rs61114099 chr4:98931270 C/T cg05340658 chr4:99064831 C4orf37 0.6 9.35 0.46 1.41e-18 Colonoscopy-negative controls vs population controls; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg03900353 chr1:212732456 NA 0.43 6.2 0.32 1.73e-9 Intelligence (multi-trait analysis); CRC cis rs6951245 1.000 rs11768761 chr7:1069807 A/G cg03188948 chr7:1209495 NA 0.63 6.52 0.34 2.64e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs7113874 0.569 rs11041962 chr11:8549623 C/T cg20771178 chr11:8615675 STK33 -0.34 -5.69 -0.3 2.77e-8 Body mass index in physically active individuals;Body mass index (joint analysis main effects and physical activity interaction); CRC trans rs4785204 1.000 rs7193487 chr16:50093406 G/A cg07960154 chr17:37760198 NEUROD2 -0.66 -6.13 -0.32 2.45e-9 Esophageal cancer (squamous cell); CRC cis rs367615 0.537 rs1965670 chr5:108649798 A/T cg17395555 chr5:108820864 NA -0.33 -6.23 -0.32 1.43e-9 Colorectal cancer (SNP x SNP interaction); CRC cis rs6502050 0.835 rs34620191 chr17:80149532 G/A cg19223190 chr17:80058835 NA 0.39 6.21 0.32 1.62e-9 Life satisfaction; CRC cis rs12745968 0.653 rs11164796 chr1:93144080 C/T cg17283838 chr1:93427260 FAM69A -0.41 -5.68 -0.3 2.97e-8 Bipolar disorder and schizophrenia; CRC cis rs8177253 1.000 rs8177240 chr3:133477701 T/G cg08048268 chr3:133502702 NA -0.37 -6.89 -0.35 2.92e-11 Iron status biomarkers; CRC cis rs274567 0.501 rs2631368 chr5:131705297 T/G cg18758796 chr5:131593413 PDLIM4 -0.42 -6.92 -0.36 2.44e-11 Blood metabolite levels; CRC cis rs861020 0.563 rs12046618 chr1:210043135 C/T cg05527609 chr1:210001259 C1orf107 0.87 9.91 0.48 2.02e-20 Orofacial clefts; CRC cis rs1005277 0.522 rs9418276 chr10:37940116 G/T cg00409905 chr10:38381863 ZNF37A -0.63 -9.97 -0.48 1.25e-20 Extrinsic epigenetic age acceleration; CRC cis rs7215564 0.908 rs77750710 chr17:78717117 C/T cg09596252 chr17:78655493 RPTOR 0.62 6.24 0.33 1.35e-9 Myopia (pathological); CRC cis rs1218582 0.772 rs4845400 chr1:154872523 C/T cg09359103 chr1:154839909 KCNN3 -0.71 -12.57 -0.57 7.63e-30 Prostate cancer; CRC cis rs6681460 0.901 rs1570815 chr1:67139667 C/T cg02459107 chr1:67143332 SGIP1 0.48 8.48 0.42 7.96e-16 Presence of antiphospholipid antibodies; CRC cis rs4713118 0.955 rs9468200 chr6:27683063 T/A cg19041857 chr6:27730383 NA -0.44 -5.99 -0.31 5.36e-9 Parkinson's disease; CRC cis rs6840360 1.000 rs7671651 chr4:152597202 C/G cg09659197 chr4:152720779 NA 0.52 11.24 0.53 4.87e-25 Intelligence (multi-trait analysis); CRC cis rs4561483 0.801 rs251723 chr16:11953080 G/C cg08843971 chr16:11963173 GSPT1 -0.62 -9.76 -0.47 6.12e-20 Testicular germ cell tumor; CRC cis rs3785574 0.924 rs2584641 chr17:61862889 A/G cg23090583 chr17:61904693 PSMC5;FTSJ3 0.66 9.63 0.47 1.72e-19 Height; CRC trans rs2727020 0.664 rs4929893 chr11:49196332 C/T cg11707556 chr5:10655725 ANKRD33B -0.38 -7.0 -0.36 1.44e-11 Coronary artery disease; CRC cis rs898097 0.841 rs12453162 chr17:80859971 C/T cg16060761 chr17:80687452 NA 0.45 6.55 0.34 2.23e-10 Breast cancer; CRC cis rs6693567 0.545 rs1260403 chr1:150303666 A/G cg15654264 chr1:150340011 RPRD2 0.42 6.29 0.33 1.04e-9 Migraine; CRC trans rs61931739 0.571 rs4001689 chr12:34243271 C/T cg26384229 chr12:38710491 ALG10B 0.5 6.51 0.34 2.83e-10 Morning vs. evening chronotype; CRC cis rs4665809 0.531 rs34081866 chr2:26475940 C/T cg22920501 chr2:26401640 FAM59B 0.84 12.46 0.57 1.94e-29 Gut microbiome composition (summer); CRC cis rs728616 0.867 rs61859008 chr10:81831711 C/G cg11900509 chr10:81946545 ANXA11 -0.52 -5.7 -0.3 2.73e-8 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs7208859 0.623 rs56812022 chr17:29068733 A/G cg13385521 chr17:29058706 SUZ12P 0.72 8.17 0.41 6.77e-15 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs17826219 0.500 rs2449749 chr17:29078298 C/T cg13385521 chr17:29058706 SUZ12P 0.72 8.24 0.41 4.19e-15 Body mass index; CRC cis rs1801251 1.000 rs3817311 chr2:233612557 C/T cg25237894 chr2:233734115 C2orf82 0.54 8.8 0.44 7.77e-17 Coronary artery disease; CRC cis rs673253 0.686 rs2842187 chr1:44014949 A/G cg10881128 chr1:44031826 PTPRF -0.21 -5.7 -0.3 2.61e-8 Intelligence (multi-trait analysis); CRC cis rs11190604 1.000 rs11190607 chr10:102303614 C/T cg16342193 chr10:102329863 NA -0.36 -5.98 -0.31 5.93e-9 Palmitoleic acid (16:1n-7) levels; CRC cis rs9527 0.590 rs7087040 chr10:104799668 G/A cg15744005 chr10:104629667 AS3MT -0.3 -5.95 -0.31 6.97e-9 Arsenic metabolism; CRC cis rs67311347 0.955 rs6773383 chr3:40377412 A/T cg09455208 chr3:40491958 NA 0.44 9.01 0.45 1.66e-17 Renal cell carcinoma; CRC cis rs897984 0.806 rs12924903 chr16:30928970 C/T cg00531865 chr16:30841666 NA -0.43 -6.08 -0.32 3.34e-9 Dementia with Lewy bodies; CRC cis rs2075371 1.000 rs1862051 chr7:133981021 G/A cg02659138 chr7:134003124 SLC35B4 0.4 6.94 0.36 2.11e-11 Mean platelet volume; CRC cis rs9916302 0.808 rs12947281 chr17:37652210 G/T cg00129232 chr17:37814104 STARD3 -0.54 -8.14 -0.41 8.25e-15 Glomerular filtration rate (creatinine); CRC cis rs68170813 0.559 rs6967638 chr7:106929356 T/G cg02696742 chr7:106810147 HBP1 -0.61 -6.74 -0.35 7.22e-11 Coronary artery disease; CRC cis rs10504229 0.683 rs2318148 chr8:58114955 G/A cg02725872 chr8:58115012 NA -0.65 -11.61 -0.54 2.36e-26 Developmental language disorder (linguistic errors); CRC cis rs9611565 0.649 rs202655 chr22:41841564 G/C cg06481639 chr22:41940642 POLR3H 0.5 6.1 0.32 2.99e-9 Vitiligo; CRC cis rs4253772 0.550 rs6007830 chr22:46711323 C/T cg24881330 chr22:46731750 TRMU 0.58 6.16 0.32 2.08e-9 LDL cholesterol;Cholesterol, total; CRC cis rs7811142 1.000 rs7783550 chr7:99987805 A/G cg21679810 chr7:100027352 MEPCE;ZCWPW1 -0.94 -13.06 -0.58 1.13e-31 Platelet count; CRC cis rs2976388 0.533 rs12543368 chr8:143819450 T/C cg24634471 chr8:143751801 JRK -0.5 -6.84 -0.35 3.91e-11 Urinary tract infection frequency; CRC cis rs473651 0.506 rs561264 chr2:239329979 G/T cg21699342 chr2:239360505 ASB1 0.44 6.8 0.35 5.01e-11 Multiple system atrophy; CRC cis rs9649213 0.574 rs3801257 chr7:97991792 A/G cg24562669 chr7:97807699 LMTK2 0.42 7.0 0.36 1.45e-11 Prostate cancer (SNP x SNP interaction); CRC cis rs1448094 0.511 rs2405616 chr12:86148042 A/G cg25456477 chr12:86230367 RASSF9 -0.36 -6.07 -0.32 3.43e-9 Major depressive disorder; CRC cis rs1153858 1.000 rs7163720 chr15:45639374 G/A cg21132104 chr15:45694354 SPATA5L1 0.58 8.61 0.43 3.09e-16 Homoarginine levels; CRC cis rs289828 0.868 rs6757821 chr2:152138037 G/A cg06191203 chr2:152266755 RIF1 -0.4 -5.72 -0.3 2.43e-8 Blood protein levels; CRC cis rs6066835 1.000 rs6122720 chr20:47351095 G/A cg18078177 chr20:47281410 PREX1 0.64 5.74 0.3 2.14e-8 Multiple myeloma; CRC trans rs916888 0.738 rs199515 chr17:44856641 C/G cg22433210 chr17:43662623 NA -0.79 -8.7 -0.43 1.62e-16 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs12142240 0.692 rs7532149 chr1:46824932 A/C cg00530320 chr1:46809349 NSUN4 0.59 8.03 0.41 1.69e-14 Menopause (age at onset); CRC cis rs7945705 0.747 rs2568045 chr11:9004060 T/C cg12365402 chr11:9010492 NRIP3 -0.57 -10.55 -0.5 1.29e-22 Hemoglobin concentration; CRC cis rs13191362 1.000 rs13204013 chr6:163002480 T/A cg21926612 chr6:163149169 PACRG;PARK2 0.8 11.25 0.53 4.59e-25 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs79839061 0.536 rs3775128 chr4:885828 T/C cg07828340 chr4:882639 GAK 0.63 6.82 0.35 4.49e-11 Intelligence (multi-trait analysis); CRC cis rs9311474 0.569 rs7614981 chr3:52566914 G/T cg18591801 chr3:52553433 STAB1 -0.29 -5.64 -0.3 3.63e-8 Electroencephalogram traits; CRC cis rs11628318 0.614 rs62007936 chr14:103198740 G/A cg23071808 chr14:103021642 NA 0.61 6.55 0.34 2.28e-10 Platelet count; CRC cis rs9326248 0.953 rs634960 chr11:117072963 T/C cg26566898 chr11:117069891 TAGLN -0.45 -9.62 -0.47 1.85e-19 Blood protein levels; CRC cis rs7208859 0.623 rs60890550 chr17:29030861 A/G cg01831904 chr17:28903510 LRRC37B2 -0.63 -6.4 -0.33 5.28e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs3820928 0.967 rs16822905 chr2:227770727 G/C cg11843606 chr2:227700838 RHBDD1 -0.42 -5.93 -0.31 7.52e-9 Pulmonary function; CRC cis rs798766 1.000 rs3099555 chr4:1725651 T/C cg05874882 chr4:1763078 NA -0.35 -6.55 -0.34 2.27e-10 Bladder cancer;Urinary bladder cancer; CRC cis rs11098499 0.863 rs10030660 chr4:120436704 G/A cg24375607 chr4:120327624 NA 0.48 7.3 0.37 2.2e-12 Corneal astigmatism; CRC cis rs9488822 0.636 rs7745074 chr6:116347432 G/A cg05304507 chr6:116381966 FRK 0.3 8.22 0.41 4.59e-15 Cholesterol, total;LDL cholesterol; CRC cis rs7474896 0.559 rs10740949 chr10:37978435 A/G cg25427524 chr10:38739819 LOC399744 -0.58 -7.28 -0.37 2.53e-12 Obesity (extreme); CRC trans rs9784649 1.000 rs56004901 chr5:24998968 A/G cg11038491 chr20:34638489 LOC647979 -0.59 -7.06 -0.36 9.96e-12 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs12249377 0.519 rs10881838 chr10:92590233 A/G cg14313238 chr10:92632228 RPP30 0.47 6.51 0.34 2.88e-10 White matter microstructure (global fractional anisotropy); CRC cis rs7737355 0.947 rs6596027 chr5:130879547 A/G cg06307176 chr5:131281290 NA 0.44 6.45 0.34 3.9e-10 Life satisfaction; CRC cis rs877282 1.000 rs34257857 chr10:772993 C/A cg06581033 chr10:766294 NA -0.47 -5.71 -0.3 2.58e-8 Uric acid levels; CRC cis rs9896052 0.625 rs11656558 chr17:73440437 T/C cg25649188 chr17:73499917 CASKIN2 0.63 6.35 0.33 7.18e-10 Sight-threatening diabetic retinopathy in type 2 diabetes; CRC cis rs7591163 0.959 rs11685995 chr2:228722008 T/C cg14646075 chr2:228736089 WDR69 -0.43 -5.88 -0.31 1.03e-8 Blood pressure; CRC trans rs3749237 0.964 rs62260719 chr3:49852419 G/A cg21659725 chr3:3221576 CRBN 0.58 8.13 0.41 8.73e-15 Resting heart rate; CRC cis rs28493229 0.786 rs73546894 chr19:41189203 C/T cg21869046 chr19:41225005 ITPKC 0.42 6.19 0.32 1.79e-9 Kawasaki disease; CRC cis rs2075371 0.863 rs12707139 chr7:133954153 A/G cg20476274 chr7:133979776 SLC35B4 0.72 11.95 0.55 1.38e-27 Mean platelet volume; CRC cis rs35306767 0.715 rs11253539 chr10:1011347 G/A cg26597838 chr10:835615 NA 0.94 11.01 0.52 3.17e-24 Eosinophil percentage of granulocytes; CRC trans rs10506458 0.915 rs2013050 chr12:63394310 C/T cg03429785 chr15:59498649 MYO1E;LDHAL6B -1.45 -21.41 -0.76 2.58e-64 Hemostatic factors and hematological phenotypes; CRC cis rs9443645 0.901 rs9352664 chr6:79566162 G/T cg09184832 chr6:79620586 NA -0.5 -9.44 -0.46 7.12e-19 Intelligence (multi-trait analysis); CRC cis rs4713118 0.662 rs149946 chr6:27970031 A/C cg15845792 chr6:28175446 NA -0.87 -12.77 -0.58 1.33e-30 Parkinson's disease; CRC cis rs9814567 1.000 rs7433663 chr3:134235790 A/G cg06541857 chr3:134203789 ANAPC13;CEP63 -0.39 -5.77 -0.3 1.8e-8 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs7044106 0.762 rs10818471 chr9:123394045 A/G cg09419670 chr9:123605666 PSMD5;LOC253039 0.7 10.73 0.51 3.02e-23 Hip circumference adjusted for BMI; CRC cis rs2842992 0.789 rs4276525 chr6:160193612 G/A cg19482086 chr6:160211437 TCP1;MRPL18 0.73 9.71 0.47 9.15e-20 Age-related macular degeneration (geographic atrophy); CRC cis rs7119 0.931 rs59418918 chr15:77833110 A/C cg27398640 chr15:77910606 LINGO1 -0.41 -7.43 -0.38 9.4e-13 Type 2 diabetes; CRC trans rs7819412 0.775 rs2001329 chr8:10986859 C/T cg16141378 chr3:129829833 LOC729375 0.45 6.34 0.33 7.38e-10 Triglycerides; CRC cis rs4711350 0.765 rs943473 chr6:33743651 G/C cg07979401 chr6:33739406 LEMD2 -0.45 -5.92 -0.31 8e-9 Schizophrenia; CRC cis rs4713118 0.513 rs149951 chr6:28033087 T/C cg18032046 chr6:28092343 ZSCAN16 -0.42 -5.75 -0.3 2.06e-8 Parkinson's disease; CRC cis rs853679 1.000 rs9986596 chr6:28219661 G/A cg15786705 chr6:28176104 NA 0.64 6.42 0.33 4.71e-10 Depression; CRC cis rs1048238 0.846 rs945420 chr1:16345208 G/A cg10494257 chr1:16342123 HSPB7 0.39 5.66 0.3 3.36e-8 Systolic blood pressure; CRC cis rs7799006 0.527 rs73039284 chr7:2221583 C/G cg04267008 chr7:1944627 MAD1L1 -0.46 -5.82 -0.31 1.41e-8 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg03395546 chr19:41222599 ADCK4;ITPKC 0.39 6.04 0.32 4.14e-9 Obesity-related traits; CRC cis rs13108904 0.934 rs13115173 chr4:1316824 T/C cg05665937 chr4:1216051 CTBP1 0.39 5.71 0.3 2.49e-8 Obesity-related traits; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg22704915 chr10:73079101 SLC29A3 0.36 6.33 0.33 8.17e-10 Liver disease severity in Alagille syndrome; CRC cis rs2180341 0.618 rs11154396 chr6:127638911 C/T cg27446573 chr6:127587934 RNF146 0.62 9.19 0.45 4.5e-18 Breast cancer; CRC cis rs617791 0.530 rs7952056 chr11:65744597 C/T cg27068330 chr11:65405492 SIPA1 -0.48 -6.76 -0.35 6.21e-11 Breast cancer; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg15646900 chr8:54755681 ATP6V1H 0.4 6.7 0.35 9.22e-11 Liver disease severity in Alagille syndrome; CRC cis rs1448094 0.817 rs12370270 chr12:86343303 T/G cg25456477 chr12:86230367 RASSF9 0.33 5.63 0.3 3.82e-8 Major depressive disorder; CRC cis rs6504622 0.537 rs1662577 chr17:44996759 C/A cg16759221 chr17:45003025 GOSR2 -0.65 -10.51 -0.5 1.84e-22 Orofacial clefts; CRC cis rs7538876 0.935 rs1408420 chr1:17754815 A/G cg01904812 chr1:17746340 RCC2 -0.41 -6.44 -0.33 4.15e-10 Basal cell carcinoma; CRC cis rs78456975 1.000 rs11891809 chr2:1566001 A/G cg26248373 chr2:1572462 NA -0.71 -8.09 -0.41 1.2e-14 Placebo response in major depressive disorder (% change in symptom score); CRC cis rs7586879 0.796 rs10187348 chr2:25078415 G/C cg22495460 chr2:25135724 ADCY3 -0.82 -13.4 -0.59 5.5e-33 Body mass index; CRC cis rs7493 0.755 rs2375001 chr7:94964640 A/T cg19678392 chr7:94953810 PON1 -0.52 -6.58 -0.34 1.84e-10 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs1799949 0.965 rs9646418 chr17:41425901 A/G cg05368731 chr17:41323189 NBR1 0.57 8.66 0.43 2.08e-16 Menopause (age at onset); CRC trans rs57221529 0.766 rs4957053 chr5:575927 T/C cg11887960 chr12:57824829 NA 0.62 6.76 0.35 6.26e-11 Lung disease severity in cystic fibrosis; CRC cis rs1799949 1.000 rs3092994 chr17:41215825 C/T cg01879757 chr17:41196368 BRCA1 -0.43 -6.63 -0.34 1.4e-10 Menopause (age at onset); CRC cis rs2920503 1.000 rs2920503 chr3:12324230 C/T cg04748988 chr3:12329223 PPARG 0.59 7.69 0.39 1.69e-13 LDL cholesterol; CRC cis rs6740322 1.000 rs6756736 chr2:43558743 C/T cg06169590 chr2:43455088 ZFP36L2;LOC100129726 -0.59 -7.42 -0.38 1.03e-12 Coronary artery disease; CRC cis rs12701220 0.503 rs12702047 chr7:1132720 G/A cg02733842 chr7:1102375 C7orf50 -0.78 -8.86 -0.44 5.21e-17 Bronchopulmonary dysplasia; CRC cis rs7493 0.901 rs17883318 chr7:94958312 G/A cg20119798 chr7:94954144 PON1 -0.43 -5.99 -0.31 5.36e-9 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs9487051 0.837 rs4403290 chr6:109611583 A/T cg01475377 chr6:109611718 NA -0.49 -9.24 -0.45 3.04e-18 Reticulocyte fraction of red cells; CRC trans rs4130344 0.555 rs7664271 chr4:159865915 C/G cg10773016 chr4:6690812 NA 0.4 6.1 0.32 3.04e-9 Intelligence (multi-trait analysis); CRC trans rs916888 0.773 rs199533 chr17:44828931 G/A cg23590916 chr17:43697445 MGC57346 0.7 6.88 0.35 3.09e-11 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs12291225 0.637 rs8570 chr11:14300759 C/G cg05501817 chr11:14380813 RRAS2 -0.45 -5.99 -0.31 5.42e-9 Sense of smell; CRC cis rs116095464 0.558 rs2288459 chr5:231143 T/C cg22857025 chr5:266934 NA -1.2 -16.38 -0.67 1.6e-44 Breast cancer; CRC cis rs2243480 0.803 rs34804747 chr7:65412942 G/C cg12463550 chr7:65579703 CRCP 0.62 5.95 0.31 6.68e-9 Diabetic kidney disease; CRC cis rs11148252 0.595 rs9526968 chr13:53240183 T/C cg12458913 chr13:53173898 NA 0.76 13.84 0.61 1.2e-34 Lewy body disease; CRC cis rs8072100 0.745 rs7214410 chr17:45422628 A/G cg25173405 chr17:45401733 C17orf57 -0.52 -8.55 -0.43 4.59e-16 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs8170 0.603 rs11086068 chr19:17420165 T/C cg04749549 chr19:17459798 NA -0.45 -7.65 -0.39 2.3e-13 Breast cancer (estrogen-receptor negative);Breast Cancer in BRCA1 mutation carriers;Ovarian cancer;Breast cancer;Epithelial ovarian cancer; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg00400810 chr15:42066822 MAPKBP1 0.37 5.97 0.31 6.31e-9 Liver disease severity in Alagille syndrome; CRC cis rs6834538 0.520 rs34812023 chr4:113423634 A/T cg10021238 chr4:113569128 MIR367;LARP7 -0.36 -5.63 -0.3 3.97e-8 Free thyroxine concentration; CRC cis rs1552244 0.572 rs113406084 chr3:10170190 T/C cg02579736 chr3:10068473 FANCD2;CIDECP 1.01 11.62 0.54 2.28e-26 Alzheimer's disease; CRC cis rs4253772 0.591 rs6008384 chr22:46655948 T/C cg03482458 chr22:46692211 CN5H6.4;GTSE1 0.52 6.92 0.36 2.33e-11 LDL cholesterol;Cholesterol, total; CRC cis rs6952808 0.609 rs4721190 chr7:1954732 A/G cg22963979 chr7:1858916 MAD1L1 0.46 7.2 0.37 4.11e-12 Bipolar disorder and schizophrenia; CRC cis rs9649465 0.967 rs2286831 chr7:123303477 A/G cg03229431 chr7:123269106 ASB15 -0.37 -5.69 -0.3 2.82e-8 Migraine; CRC cis rs9534288 0.843 rs4362286 chr13:46566514 G/A cg15192986 chr13:46630673 CPB2 -0.67 -9.86 -0.48 2.81e-20 Blood protein levels; CRC cis rs9534288 0.762 rs4941539 chr13:46597067 A/T cg15192986 chr13:46630673 CPB2 -0.67 -9.81 -0.48 4.16e-20 Blood protein levels; CRC cis rs9549367 0.789 rs35569628 chr13:113872712 T/C cg00898013 chr13:113819073 PROZ -0.4 -5.78 -0.3 1.74e-8 Platelet distribution width; CRC cis rs2573652 1.000 rs12440866 chr15:100517010 G/A cg00587665 chr15:100533223 ADAMTS17 -0.39 -6.73 -0.35 7.64e-11 Height; CRC cis rs11212617 0.967 rs664982 chr11:108225483 C/T cg14761454 chr11:108092087 ATM;NPAT 0.44 6.68 0.35 1.03e-10 Response to metformin in type 2 diabetes (glycemic); CRC trans rs6951245 1.000 rs78143408 chr7:1096846 G/A cg13565492 chr6:43139072 SRF -0.71 -7.38 -0.38 1.32e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs4332037 0.624 rs58169303 chr7:1883274 T/C cg23422044 chr7:1970798 MAD1L1 -0.49 -6.39 -0.33 5.79e-10 Bipolar disorder; CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg03664139 chr6:101329504 ASCC3 -0.52 -6.32 -0.33 8.68e-10 Diisocyanate-induced asthma; CRC cis rs7973719 1.000 rs7973719 chr12:7334813 C/T cg07052231 chr12:7363540 PEX5 0.48 7.92 0.4 3.77e-14 IgG glycosylation; CRC cis rs926938 0.527 rs360679 chr1:115494121 G/T cg12756093 chr1:115239321 AMPD1 0.48 7.13 0.37 6.23e-12 Autism; CRC cis rs7647973 1.000 rs56127630 chr3:49438036 C/G cg07690219 chr3:49449608 TCTA;RHOA 0.5 5.67 0.3 3.16e-8 Menarche (age at onset); CRC cis rs514406 0.505 rs416968 chr1:53183513 A/G cg25767906 chr1:53392781 SCP2 -0.37 -5.96 -0.31 6.63e-9 Monocyte count; CRC cis rs2814982 0.543 rs75776386 chr6:34465215 G/A cg17674042 chr6:34482479 PACSIN1 -1.01 -11.11 -0.52 1.44e-24 Cholesterol, total;Total cholesterol levels; CRC cis rs2153535 0.580 rs6912374 chr6:8456423 T/C cg21535247 chr6:8435926 SLC35B3 0.51 7.74 0.39 1.24e-13 Motion sickness; CRC cis rs6121246 0.909 rs2376992 chr20:30263418 T/C cg13852791 chr20:30311386 BCL2L1 0.69 10.9 0.51 8.2e-24 Mean corpuscular hemoglobin; CRC cis rs72781680 0.752 rs55859418 chr2:23904231 C/A cg08917208 chr2:24149416 ATAD2B 1.02 9.31 0.46 1.83e-18 Lymphocyte counts; CRC cis rs9443645 0.901 rs1890229 chr6:79695029 C/T cg05283184 chr6:79620031 NA -0.59 -9.16 -0.45 5.75e-18 Intelligence (multi-trait analysis); CRC trans rs7267979 1.000 rs2500404 chr20:25359758 A/C cg17903999 chr18:56338584 MALT1 0.41 6.54 0.34 2.39e-10 Liver enzyme levels (alkaline phosphatase); CRC cis rs4713118 0.662 rs149961 chr6:28015569 A/C cg15786705 chr6:28176104 NA 0.68 9.22 0.45 3.55e-18 Parkinson's disease; CRC cis rs3849570 1.000 rs4411908 chr3:81802418 A/C cg07356753 chr3:81810745 GBE1 -0.61 -8.58 -0.43 3.93e-16 Waist circumference;Body mass index; CRC cis rs4680 1.000 rs4633 chr22:19950235 C/T cg22546130 chr22:19950026 COMT 0.28 7.74 0.39 1.24e-13 Blood metabolite levels; CRC cis rs911555 0.692 rs60235428 chr14:103904350 T/C cg12935359 chr14:103987150 CKB 0.56 9.13 0.45 7.33e-18 Intelligence (multi-trait analysis); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg25733915 chr17:40829168 PLEKHH3 0.43 6.0 0.31 5.29e-9 Response to antipsychotic treatment; CRC cis rs3806843 0.966 rs11953833 chr5:140155123 T/A cg16607685 chr5:140181889 PCDHA2;PCDHA1;PCDHA3 -0.25 -5.79 -0.3 1.65e-8 Depressive symptoms (multi-trait analysis); CRC cis rs2836974 0.644 rs9978775 chr21:40694526 A/G cg06238570 chr21:40685208 BRWD1 -0.83 -12.84 -0.58 7.05e-31 Cognitive function; CRC cis rs10751667 1.000 rs7395691 chr11:985006 T/C cg23136738 chr11:925521 AP2A2 -0.48 -7.61 -0.39 2.91e-13 Alzheimer's disease (late onset); CRC cis rs875971 0.862 rs1860469 chr7:66106875 A/G cg11764359 chr7:65958608 NA -0.59 -8.76 -0.44 1.03e-16 Aortic root size; CRC cis rs7772486 0.720 rs4896837 chr6:146014168 C/T cg13319975 chr6:146136371 FBXO30 0.44 6.43 0.33 4.44e-10 Lobe attachment (rater-scored or self-reported); CRC cis rs9902453 1.000 rs28664971 chr17:28437410 A/C cg26525008 chr17:28256777 EFCAB5;SSH2 0.72 11.98 0.55 1.12e-27 Coffee consumption (cups per day); CRC cis rs2415984 0.579 rs10151988 chr14:46955203 C/T cg14871534 chr14:47121158 RPL10L -0.41 -6.02 -0.31 4.74e-9 Number of children ever born; CRC cis rs514406 0.861 rs6588443 chr1:53250650 G/A cg27535305 chr1:53392650 SCP2 0.39 7.03 0.36 1.21e-11 Monocyte count; CRC cis rs11785400 0.793 rs4403386 chr8:143736770 C/G cg24634471 chr8:143751801 JRK 0.47 6.43 0.33 4.4e-10 Schizophrenia; CRC cis rs10089 1.000 rs4836370 chr5:127499224 A/G cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.76 10.73 0.51 3.01e-23 Ileal carcinoids; CRC cis rs4926298 1.000 rs11085829 chr19:13174312 G/A cg04657146 chr19:12876947 HOOK2 -0.43 -5.79 -0.3 1.61e-8 Bipolar disorder; CRC cis rs11931598 0.514 rs10937779 chr4:7039326 G/A cg26116260 chr4:7069785 GRPEL1 0.54 8.51 0.42 6.17e-16 Sum basophil neutrophil counts;Sum neutrophil eosinophil counts;Granulocyte count;Neutrophil count;Myeloid white cell count; CRC cis rs826838 0.967 rs4768329 chr12:39129394 T/C cg26384229 chr12:38710491 ALG10B -0.64 -9.63 -0.47 1.66e-19 Heart rate; CRC cis rs3858526 0.959 rs11039540 chr11:5928334 C/T cg05234568 chr11:5960015 NA -0.56 -7.76 -0.39 1.1e-13 DNA methylation (variation); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg13411879 chr7:30068273 PLEKHA8 0.41 6.3 0.33 9.7e-10 Liver disease severity in Alagille syndrome; CRC cis rs8177253 0.931 rs8177256 chr3:133480276 G/T cg01448562 chr3:133502909 NA -0.53 -9.09 -0.45 9.72e-18 Iron status biomarkers; CRC cis rs9491140 0.539 rs911959 chr6:124688755 A/G cg22366943 chr6:124882293 NKAIN2 0.51 7.73 0.39 1.31e-13 Neuroticism; CRC cis rs1552244 0.935 rs11926481 chr3:10142102 G/T cg10729496 chr3:10149963 C3orf24 0.49 6.66 0.34 1.18e-10 Alzheimer's disease; CRC cis rs4731207 0.698 rs12536575 chr7:124510276 G/A cg23710748 chr7:124431027 NA -0.38 -6.08 -0.32 3.42e-9 Cutaneous malignant melanoma; CRC cis rs10504229 0.775 rs56082079 chr8:58163732 T/C cg05313129 chr8:58192883 C8orf71 -0.49 -6.22 -0.32 1.49e-9 Developmental language disorder (linguistic errors); CRC cis rs1707322 0.964 rs6697830 chr1:46290477 C/A cg06784218 chr1:46089804 CCDC17 0.5 8.93 0.44 3.14e-17 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs172166 0.561 rs149974 chr6:27985096 T/C cg21251018 chr6:28226885 NKAPL 0.57 9.8 0.48 4.44e-20 Cardiac Troponin-T levels; CRC cis rs1448094 0.512 rs7303330 chr12:86255123 G/A cg00310523 chr12:86230176 RASSF9 0.34 5.75 0.3 2.08e-8 Major depressive disorder; CRC cis rs9457247 0.846 rs2757052 chr6:167380174 T/C cg23791538 chr6:167370224 RNASET2 0.39 6.09 0.32 3.22e-9 Crohn's disease; CRC cis rs2227564 0.761 rs2227552 chr10:75669319 C/T cg00564723 chr10:75632066 CAMK2G -0.31 -7.23 -0.37 3.51e-12 Crohn's disease;Inflammatory bowel disease; CRC cis rs16867321 1.000 rs1358521 chr2:181444628 T/C cg23363182 chr2:181467187 NA -0.54 -6.87 -0.35 3.29e-11 Obesity; CRC cis rs35306767 0.903 rs12769002 chr10:927666 C/G cg26597838 chr10:835615 NA -1.2 -14.36 -0.62 1.21e-36 Eosinophil percentage of granulocytes; CRC cis rs7746199 0.668 rs34864796 chr6:27459923 G/A cg03623178 chr6:28175578 NA 0.75 5.99 0.31 5.52e-9 Gait speed in old age;Autism spectrum disorder or schizophrenia; CRC cis rs11098499 0.691 rs17009144 chr4:120270795 C/T cg09307838 chr4:120376055 NA -0.59 -9.27 -0.46 2.5e-18 Corneal astigmatism; CRC cis rs17345786 0.798 rs4257518 chr3:101281709 C/T cg12386194 chr3:101231763 SENP7 -0.49 -6.76 -0.35 6.31e-11 Colonoscopy-negative controls vs population controls; CRC cis rs8078723 0.677 rs8073254 chr17:38149350 C/G cg17467752 chr17:38218738 THRA -0.57 -9.13 -0.45 6.89e-18 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg16449816 chr17:55927528 MRPS23 0.37 6.1 0.32 2.99e-9 Liver disease severity in Alagille syndrome; CRC trans rs9291683 0.588 rs35438220 chr4:9999398 C/T cg26043149 chr18:55253948 FECH 0.51 7.95 0.4 3.02e-14 Bone mineral density; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg24540109 chr1:32110960 PEF1 0.41 6.07 0.32 3.59e-9 Intelligence (multi-trait analysis); CRC cis rs4713118 0.869 rs9283880 chr6:27715243 A/C cg12273811 chr6:28175739 NA 0.54 7.72 0.39 1.43e-13 Parkinson's disease; CRC cis rs4285028 0.948 rs34837785 chr3:121657776 G/A cg20356878 chr3:121714668 ILDR1 -0.47 -6.61 -0.34 1.57e-10 Multiple sclerosis; CRC cis rs9322193 0.923 rs9689599 chr6:149953109 A/C cg13206674 chr6:150067644 NUP43 0.65 9.76 0.47 6.33e-20 Lung cancer; CRC cis rs13031619 0.950 rs7589966 chr2:3696636 A/G cg00999904 chr2:3704751 ALLC 0.49 6.72 0.35 7.97e-11 Response to inhaled corticosteroid treatment in asthma (change in FEV1); CRC cis rs3741404 0.620 rs2236648 chr11:63964657 C/T cg14078730 chr11:63896557 MACROD1 0.35 5.62 0.3 4.08e-8 Platelet count; CRC cis rs11030122 0.673 rs10835508 chr11:4045360 A/T cg18678763 chr11:4115507 RRM1 -0.48 -7.96 -0.4 2.75e-14 Mean platelet volume;Platelet distribution width; CRC trans rs7395662 0.500 rs7951327 chr11:48925359 C/T cg03929089 chr4:120376271 NA -0.49 -7.08 -0.36 8.76e-12 HDL cholesterol; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg19259146 chr1:26856420 RPS6KA1 0.41 6.07 0.32 3.45e-9 Intelligence (multi-trait analysis); CRC cis rs798554 0.704 rs2527684 chr7:2825922 G/T cg19717773 chr7:2847554 GNA12 -0.45 -7.49 -0.38 6.22e-13 Height; CRC cis rs2075371 0.966 rs2544214 chr7:133985736 G/A cg20476274 chr7:133979776 SLC35B4 0.82 15.11 0.64 1.57e-39 Mean platelet volume; CRC cis rs2688608 0.839 rs2633311 chr10:75598099 C/T cg00564723 chr10:75632066 CAMK2G 0.24 6.13 0.32 2.51e-9 Inflammatory bowel disease; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg04981737 chr12:54383434 HOXC10 0.39 6.07 0.32 3.47e-9 Liver disease severity in Alagille syndrome; CRC cis rs262150 0.659 rs2527236 chr7:158796644 C/T cg19418458 chr7:158789849 NA -0.52 -9.01 -0.44 1.74e-17 Facial morphology (factor 20); CRC cis rs7618915 0.547 rs2268026 chr3:52778347 T/C cg11645453 chr3:52864694 ITIH4 0.35 6.02 0.32 4.62e-9 Bipolar disorder; CRC trans rs4650994 0.544 rs10798613 chr1:178500022 C/T cg05059571 chr16:84539110 KIAA1609 -0.64 -8.61 -0.43 3.08e-16 HDL cholesterol levels;HDL cholesterol; CRC cis rs6951245 0.638 rs74976697 chr7:1160505 C/T cg20603222 chr7:1096387 C7orf50;GPR146 -0.64 -8.01 -0.4 2.05e-14 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs8060686 0.641 rs113790673 chr16:68244347 C/T cg08314208 chr16:67682810 RLTPR -0.6 -6.42 -0.33 4.82e-10 HDL cholesterol;Metabolic syndrome; CRC cis rs1218582 0.772 rs4240874 chr1:154885779 C/T cg09359103 chr1:154839909 KCNN3 -0.7 -12.43 -0.57 2.36e-29 Prostate cancer; CRC cis rs9322193 0.923 rs57012784 chr6:149948827 G/A cg05861140 chr6:150128134 PCMT1 -0.36 -5.9 -0.31 8.8e-9 Lung cancer; CRC cis rs7215564 0.908 rs2316067 chr17:78659720 C/T cg09596252 chr17:78655493 RPTOR 0.53 5.62 0.3 4.14e-8 Myopia (pathological); CRC cis rs9488822 0.676 rs1999929 chr6:116381994 T/C cg26893134 chr6:116381904 FRK 0.28 8.01 0.4 2e-14 Cholesterol, total;LDL cholesterol; CRC cis rs1538970 0.962 rs2153608 chr1:45813941 C/T cg05343316 chr1:45956843 TESK2 -0.64 -9.09 -0.45 9.56e-18 Platelet count; CRC cis rs1524976 1.000 rs62255280 chr3:65483527 T/C cg16238336 chr3:65465873 MAGI1 -0.52 -6.76 -0.35 6.14e-11 PR interval; CRC cis rs720844 1.000 rs16829006 chr2:149335661 C/T cg09247360 chr2:149335327 NA -0.61 -7.7 -0.39 1.5700000000000001e-13 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs6502050 0.787 rs11653012 chr17:80058857 C/T cg13939156 chr17:80058883 NA 0.38 6.19 0.32 1.83e-9 Life satisfaction; CRC cis rs10504229 0.639 rs67002486 chr8:58117218 A/G cg02290350 chr8:58132656 NA -0.58 -8.16 -0.41 7.29e-15 Developmental language disorder (linguistic errors); CRC cis rs4908768 0.501 rs12756257 chr1:8616933 C/A cg20416874 chr1:8611966 RERE -0.44 -6.31 -0.33 9.21e-10 Neuroticism (multi-trait analysis);Subjective well-being (multi-trait analysis); CRC cis rs3749237 0.636 rs1568662 chr3:49521263 A/G cg02487422 chr3:49467188 NICN1 0.43 6.91 0.36 2.5e-11 Resting heart rate; CRC trans rs7615952 0.932 rs1976458 chr3:125647512 T/G cg00769240 chr8:12517080 NA -0.57 -7.03 -0.36 1.23e-11 Blood pressure (smoking interaction); CRC trans rs2797160 0.651 rs9491503 chr6:126031682 G/A cg05039488 chr6:79577232 IRAK1BP1 0.55 8.42 0.42 1.15e-15 Endometrial cancer; CRC cis rs4664308 0.967 rs17241973 chr2:160918601 A/G cg03641300 chr2:160917029 PLA2R1 -0.74 -11.97 -0.55 1.2100000000000001e-27 Idiopathic membranous nephropathy; CRC cis rs644799 0.511 rs12791736 chr11:95475399 C/G cg03916912 chr11:95522834 CEP57;FAM76B 0.66 10.01 0.48 9.19e-21 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs26868 0.766 rs30995 chr16:2248017 C/T cg02248941 chr16:2239361 CASKIN1 -0.61 -11.14 -0.52 1.13e-24 Height; CRC cis rs17270561 0.562 rs74293932 chr6:26014811 C/A cg16482183 chr6:26056742 HIST1H1C 1.06 12.97 0.58 2.26e-31 Iron status biomarkers; CRC cis rs4853036 0.951 rs10185266 chr2:70152407 C/G cg02498382 chr2:70120550 SNRNP27 -0.45 -6.9 -0.36 2.64e-11 Colorectal or endometrial cancer; CRC cis rs13191362 1.000 rs7769686 chr6:163199467 A/G cg06582575 chr6:163149167 PACRG;PARK2 0.87 11.16 0.52 9.41e-25 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC trans rs11764590 0.724 rs62444917 chr7:2107262 A/C cg11693508 chr17:37793320 STARD3 0.52 6.73 0.35 7.44e-11 Neuroticism; CRC cis rs425277 0.585 rs3107156 chr1:2060630 T/C cg19257562 chr1:2043853 PRKCZ 0.44 7.09 0.36 8.3e-12 Height; CRC cis rs35883536 1.000 rs17403857 chr1:101105216 A/C cg14515779 chr1:101123966 NA -0.42 -8.04 -0.41 1.63e-14 Monocyte count; CRC cis rs10751667 0.666 rs7944815 chr11:959776 C/T ch.11.42038R chr11:967971 AP2A2 0.58 10.11 0.49 4.24e-21 Alzheimer's disease (late onset); CRC cis rs826838 1.000 rs10875717 chr12:38911174 T/C cg13010199 chr12:38710504 ALG10B 0.47 6.04 0.32 4.08e-9 Heart rate; CRC cis rs13108904 0.935 rs2293633 chr4:1291640 T/C cg20092199 chr4:1342459 KIAA1530 0.41 7.49 0.38 6.31e-13 Obesity-related traits; CRC cis rs870825 0.616 rs28500698 chr4:185627746 A/C cg04058563 chr4:185651563 MLF1IP 0.72 9.38 0.46 1.12e-18 Blood protein levels; CRC trans rs116095464 0.558 rs55776650 chr5:273826 G/A cg00938859 chr5:1591904 SDHAP3 0.72 7.72 0.39 1.43e-13 Breast cancer; CRC cis rs73206853 0.698 rs59574270 chr12:111112098 A/C cg12870014 chr12:110450643 ANKRD13A 0.86 9.64 0.47 1.53e-19 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC trans rs941408 1.000 rs1640271 chr19:2799979 C/T cg08017880 chr11:407180 SIGIRR -0.43 -6.17 -0.32 2e-9 Total cholesterol levels; CRC trans rs2303319 0.504 rs56026147 chr2:162614089 T/C cg20024234 chr21:43431083 ZNF295 -0.66 -5.99 -0.31 5.57e-9 Cognitive function; CRC cis rs4727027 0.833 rs2107846 chr7:148832774 G/A cg12479418 chr7:148823350 ZNF425;ZNF398 0.45 6.03 0.32 4.33e-9 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC cis rs1865760 0.566 rs2032445 chr6:26044812 T/A cg17691542 chr6:26056736 HIST1H1C 0.55 8.29 0.42 2.95e-15 Height; CRC cis rs7223966 1.000 rs11079509 chr17:61762148 G/T cg23090583 chr17:61904693 PSMC5;FTSJ3 0.58 6.73 0.35 7.5e-11 Hip circumference adjusted for BMI;Body mass index; CRC cis rs2839186 0.500 rs13052701 chr21:47660045 A/T cg09417038 chr21:47716443 C21orf57 -0.51 -8.26 -0.41 3.63e-15 Testicular germ cell tumor; CRC cis rs873946 0.648 rs12783354 chr10:134557235 T/A cg26818010 chr10:134567672 INPP5A -0.68 -8.5 -0.42 6.71e-16 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CRC cis rs2645694 0.626 rs904050 chr4:77826089 T/G cg18351406 chr4:77819688 ANKRD56 0.53 8.02 0.4 1.93e-14 Emphysema distribution in smoking; CRC trans rs6918679 0.630 rs2353329 chr6:75549672 C/T cg15161371 chr1:3613808 TP73 0.47 5.98 0.31 5.68e-9 Venlafaxine response in generalised anxiety disorder (responders vs non-responders after 24 weeks); CRC cis rs6743376 0.556 rs2441376 chr2:113817755 T/C cg09040174 chr2:113837401 NA 0.44 6.37 0.33 6.46e-10 Inflammatory biomarkers; CRC cis rs10540 1.000 rs61876340 chr11:495699 A/C cg21784768 chr11:537496 LRRC56 -0.68 -6.51 -0.34 2.8e-10 Body mass index; CRC trans rs7301826 0.627 rs7315707 chr12:131272819 A/G cg10137463 chr15:23085908 NIPA1 0.47 6.01 0.31 4.89e-9 Plasma plasminogen activator levels; CRC cis rs17376456 0.809 rs13177800 chr5:93307350 T/C cg25358565 chr5:93447407 FAM172A 1.06 10.51 0.5 1.83e-22 Diabetic retinopathy; CRC cis rs875971 0.964 rs778708 chr7:65856319 T/C cg11764359 chr7:65958608 NA 0.61 9.95 0.48 1.41e-20 Aortic root size; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg02532999 chr21:38639929 DSCR3 0.38 6.04 0.32 4.17e-9 Liver disease severity in Alagille syndrome; CRC cis rs12291225 0.637 rs8570 chr11:14300759 C/G cg19336497 chr11:14380999 RRAS2 -0.52 -8.68 -0.43 1.83e-16 Sense of smell; CRC cis rs7833790 0.636 rs12544174 chr8:82731477 G/A cg27398817 chr8:82754497 SNX16 -0.43 -5.86 -0.31 1.13e-8 Diastolic blood pressure; CRC trans rs2303319 0.504 rs16846026 chr2:162537691 T/C cg12500891 chr11:57225987 NA -0.68 -6.07 -0.32 3.55e-9 Cognitive function; CRC cis rs7945705 0.869 rs7925728 chr11:9013002 A/G cg00186954 chr11:8933980 ST5;C11orf17 -0.39 -6.43 -0.33 4.56e-10 Hemoglobin concentration; CRC cis rs2439831 0.850 rs7174208 chr15:44052682 A/G cg02155558 chr15:43621948 ADAL;LCMT2 0.69 7.61 0.39 2.95e-13 Lung cancer in ever smokers; CRC cis rs6456156 0.586 rs12525855 chr6:167480013 T/G cg07741184 chr6:167504864 NA 0.42 7.2 0.37 4.22e-12 Primary biliary cholangitis; CRC cis rs12541635 0.677 rs1603357 chr8:107000565 G/C cg10147462 chr8:107024639 NA 0.58 10.17 0.49 2.54e-21 Age of smoking initiation; CRC cis rs2239547 0.522 rs9846976 chr3:53007995 T/C cg11645453 chr3:52864694 ITIH4 0.53 9.43 0.46 7.35e-19 Schizophrenia; CRC cis rs2179367 0.959 rs489551 chr6:149689457 A/G cg16235748 chr6:149772707 ZC3H12D -0.35 -5.7 -0.3 2.65e-8 Dupuytren's disease; CRC cis rs6942756 0.955 rs68187585 chr7:129002211 T/C cg02491457 chr7:128862824 NA -0.73 -9.59 -0.47 2.23e-19 White matter hyperintensity burden; CRC trans rs2303319 0.504 rs961421 chr2:162626099 G/C cg22677401 chr17:46026860 NA -0.67 -6.09 -0.32 3.14e-9 Cognitive function; CRC cis rs3617 0.522 rs6773650 chr3:52897095 A/T cg11645453 chr3:52864694 ITIH4 0.36 6.55 0.34 2.22e-10 Red blood cell count;Autism spectrum disorder or schizophrenia; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg14684917 chr11:62380363 EML3;ROM1 -0.38 -6.17 -0.32 1.97e-9 Myopia (pathological); CRC cis rs55871839 0.708 rs1448541 chr8:59812938 G/A cg07426533 chr8:59803705 TOX -0.34 -5.94 -0.31 7.22e-9 Pneumonia; CRC cis rs72615157 0.697 rs2056726 chr7:99780283 G/A cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.56 6.63 0.34 1.42e-10 Lung function (FEV1/FVC); CRC cis rs9611565 0.512 rs7291736 chr22:42124874 C/A cg06481639 chr22:41940642 POLR3H 0.52 5.91 0.31 8.37e-9 Vitiligo; CRC cis rs3789045 0.779 rs12043569 chr1:204560004 C/G cg17419461 chr1:204415978 PIK3C2B -0.5 -7.01 -0.36 1.35e-11 Educational attainment (college completion); CRC cis rs1552244 0.882 rs17081288 chr3:10042113 A/G cg13047869 chr3:10149882 C3orf24 0.53 7.15 0.37 5.67e-12 Alzheimer's disease; CRC cis rs4481887 0.504 rs4916107 chr1:248353621 A/G cg00666640 chr1:248458726 OR2T12 -0.43 -7.09 -0.36 8.31e-12 Common traits (Other); CRC cis rs477692 0.569 rs7087541 chr10:131309979 A/C cg05714579 chr10:131428358 MGMT 0.54 7.69 0.39 1.76e-13 Response to temozolomide; CRC cis rs4722166 0.630 rs13311199 chr7:22789793 A/C cg26061582 chr7:22766209 IL6 0.53 8.03 0.4 1.77e-14 Lung cancer; CRC cis rs7202877 0.706 rs4888375 chr16:75322356 T/C cg03315344 chr16:75512273 CHST6 0.49 5.61 0.3 4.28e-8 Type 2 diabetes;Type 1 diabetes; CRC cis rs6754311 0.773 rs309130 chr2:136631031 C/A cg25344623 chr2:136566232 LCT 0.33 6.03 0.32 4.33e-9 Mosquito bite size; CRC cis rs6743376 0.556 rs1374286 chr2:113819007 C/G cg09040174 chr2:113837401 NA 0.44 6.44 0.33 4.3e-10 Inflammatory biomarkers; CRC cis rs35306767 0.903 rs11253467 chr10:901244 A/G cg26597838 chr10:835615 NA 0.87 10.95 0.52 5.37e-24 Eosinophil percentage of granulocytes; CRC cis rs1008375 0.966 rs1476836 chr4:17585014 G/C cg16339924 chr4:17578868 LAP3 0.6 7.98 0.4 2.42e-14 Parasitemia in Tripanosoma cruzi seropositivity; CRC trans rs7819412 0.775 rs4545055 chr8:10935366 T/C cg06636001 chr8:8085503 FLJ10661 -0.61 -9.06 -0.45 1.19e-17 Triglycerides; CRC cis rs2274471 0.699 rs73395341 chr9:5085549 A/G cg03390472 chr9:5043263 JAK2 -0.57 -6.35 -0.33 7.01e-10 Crohn's disease; CRC cis rs56313388 0.793 rs9937815 chr16:56330832 C/T cg02433656 chr16:56322654 GNAO1 -0.51 -7.68 -0.39 1.78e-13 Pulse pressure; CRC cis rs9368481 0.547 rs2093303 chr6:26864406 C/T cg12292205 chr6:26970375 C6orf41 0.61 9.71 0.47 9.31e-20 Autism spectrum disorder or schizophrenia; CRC cis rs4589502 1.000 rs12440279 chr15:67133339 G/A cg12317470 chr15:67143691 NA 0.78 6.68 0.35 9.98e-11 Lung cancer (smoking interaction); CRC cis rs7692995 0.925 rs6843651 chr4:17995500 T/C cg08925142 chr4:18023851 LCORL -0.54 -5.97 -0.31 6.14e-9 Height; CRC cis rs10504229 1.000 rs66936919 chr8:58172868 C/G cg24829409 chr8:58192753 C8orf71 -0.67 -11.37 -0.53 1.7e-25 Developmental language disorder (linguistic errors); CRC cis rs904251 0.600 rs12211110 chr6:37466232 A/G cg01843034 chr6:37503916 NA -0.38 -6.73 -0.35 7.53e-11 Cognitive performance; CRC cis rs4713118 0.662 rs9380045 chr6:28025279 A/G cg12273811 chr6:28175739 NA 0.62 8.29 0.42 2.87e-15 Parkinson's disease; CRC cis rs1707322 1.000 rs11211223 chr1:46380605 C/T cg06784218 chr1:46089804 CCDC17 0.52 9.09 0.45 9.47e-18 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs9467773 0.620 rs2504599 chr6:26641060 C/T cg09904177 chr6:26538194 HMGN4 0.72 11.32 0.53 2.68e-25 Intelligence (multi-trait analysis); CRC trans rs9858542 0.953 rs11713474 chr3:49611457 A/G cg21582582 chr3:182698605 DCUN1D1 -0.54 -6.68 -0.35 1.01e-10 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC trans rs7512552 1.000 rs7512552 chr1:150265704 T/C cg02126412 chr11:112831938 NCAM1 -0.32 -6.02 -0.31 4.7e-9 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); CRC cis rs17234274 0.585 rs2128494 chr11:23234390 A/G cg05245346 chr11:23248277 NA 0.35 5.72 0.3 2.35e-8 Cancer; CRC cis rs4926298 1.000 rs4926298 chr19:13153035 C/T cg23899408 chr19:12877188 HOOK2 -0.48 -6.54 -0.34 2.38e-10 Bipolar disorder; CRC cis rs2120019 1.000 rs12898259 chr15:75369780 G/A cg09165964 chr15:75287851 SCAMP5 -0.8 -12.62 -0.57 4.92e-30 Blood trace element (Zn levels); CRC cis rs477692 0.673 rs1078847 chr10:131352115 T/C cg05714579 chr10:131428358 MGMT 0.47 6.66 0.34 1.17e-10 Response to temozolomide; CRC cis rs6502050 0.787 rs7222326 chr17:80057272 T/C cg25804541 chr17:80189381 SLC16A3 0.31 5.74 0.3 2.18e-8 Life satisfaction; CRC trans rs1376359 0.673 rs35138045 chr1:103127474 G/A cg16220183 chr17:56609687 SEPT4 -0.45 -6.04 -0.32 4.09e-9 QRS duration in Tripanosoma cruzi seropositivity; CRC cis rs873946 0.590 rs12259699 chr10:134549692 A/G cg27286337 chr10:134555280 INPP5A 0.7 9.41 0.46 8.93e-19 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg15888301 chr15:73344233 NEO1 0.38 6.16 0.32 2.16e-9 Liver disease severity in Alagille syndrome; CRC cis rs4423214 0.819 rs7938885 chr11:71170043 T/C cg05163923 chr11:71159392 DHCR7 0.66 9.38 0.46 1.13e-18 Vitamin D levels; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg00905170 chr8:67341306 RRS1 0.47 6.8 0.35 5.04e-11 Intelligence (multi-trait analysis); CRC cis rs2739330 0.828 rs2186366 chr22:24254113 A/G cg10150615 chr22:24372951 LOC391322 0.62 9.62 0.47 1.85e-19 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs644799 1.000 rs560854 chr11:95584905 G/A cg25478527 chr11:95522999 CEP57;FAM76B 0.53 7.93 0.4 3.41e-14 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs2795502 0.630 rs1271547 chr10:43507665 C/T cg20628663 chr10:43360327 NA 0.57 6.62 0.34 1.43e-10 Blood protein levels; CRC cis rs2625529 0.617 rs62023343 chr15:72174963 C/A cg16672083 chr15:72433130 SENP8 0.46 7.01 0.36 1.39e-11 Red blood cell count; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg18809821 chr6:24403225 MRS2 0.49 6.3 0.33 9.53e-10 Thyroid stimulating hormone; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg19884546 chr22:38082237 NOL12 0.54 7.48 0.38 6.82e-13 Thyroid stimulating hormone; CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg00665395 chr2:219575490 TTLL4 -0.53 -6.29 -0.33 1.03e-9 Diisocyanate-induced asthma; CRC cis rs7937682 0.889 rs1940529 chr11:111498523 G/C cg09085632 chr11:111637200 PPP2R1B -0.99 -19.69 -0.74 1.42e-57 Primary sclerosing cholangitis; CRC cis rs6921919 0.551 rs13201753 chr6:28331128 A/C cg21251018 chr6:28226885 NKAPL 0.42 6.42 0.33 4.75e-10 Autism spectrum disorder or schizophrenia; CRC cis rs9837602 1.000 rs6799379 chr3:99762840 C/T cg07805332 chr3:99536008 MIR548G;C3orf26 -0.51 -6.92 -0.36 2.35e-11 Breast cancer; CRC cis rs769267 0.965 rs2916068 chr19:19516433 A/G cg03709012 chr19:19516395 GATAD2A 0.73 11.65 0.54 1.75e-26 Tonsillectomy; CRC trans rs7267979 1.000 rs2500418 chr20:25382268 C/T cg17903999 chr18:56338584 MALT1 0.41 6.65 0.34 1.25e-10 Liver enzyme levels (alkaline phosphatase); CRC cis rs2842992 0.872 rs1570318 chr6:160111473 C/T cg11366901 chr6:160182831 ACAT2 0.88 11.77 0.54 6.18e-27 Age-related macular degeneration (geographic atrophy); CRC cis rs727505 0.954 rs59283092 chr7:124678282 T/C cg23710748 chr7:124431027 NA -0.79 -13.66 -0.6 5.72e-34 Lewy body disease; CRC cis rs951366 0.789 rs823152 chr1:205736285 G/A cg23034840 chr1:205782522 SLC41A1 0.5 6.93 0.36 2.25e-11 Menarche (age at onset); CRC cis rs747650 0.504 rs7127741 chr11:47074479 T/C cg19486271 chr11:47235900 DDB2 -0.44 -5.86 -0.31 1.11e-8 Acne (severe); CRC cis rs1570884 0.857 rs9535263 chr13:50137363 T/A cg08779649 chr13:50194554 NA 0.33 6.48 0.34 3.38e-10 Sum basophil neutrophil counts;Sum neutrophil eosinophil counts;Neutrophil count;Myeloid white cell count;Granulocyte count; CRC cis rs514406 0.627 rs485128 chr1:53344583 T/C cg25767906 chr1:53392781 SCP2 -0.51 -7.98 -0.4 2.51e-14 Monocyte count; CRC cis rs7727544 0.582 rs3749756 chr5:131534499 C/T cg12564285 chr5:131593104 PDLIM4 0.32 5.6 0.3 4.5e-8 Blood metabolite levels; CRC cis rs9611565 0.659 rs28623192 chr22:41940524 A/G cg17554472 chr22:41940697 POLR3H -0.56 -6.06 -0.32 3.72e-9 Vitiligo; CRC trans rs11148252 0.904 rs9568734 chr13:53004222 G/A cg18335740 chr13:41363409 SLC25A15 0.61 9.83 0.48 3.67e-20 Lewy body disease; CRC cis rs4319547 0.695 rs10773152 chr12:122910180 T/C cg23029597 chr12:123009494 RSRC2 -0.56 -6.96 -0.36 1.86e-11 Body mass index; CRC cis rs7493 1.000 rs2299263 chr7:95040411 A/G cg07404485 chr7:94953653 PON1 0.46 6.03 0.32 4.41e-9 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs12760731 0.720 rs12026110 chr1:178410984 G/A cg00404053 chr1:178313656 RASAL2 0.95 9.79 0.47 5.03e-20 Obesity-related traits; CRC cis rs10493773 1.000 rs10493774 chr1:86137963 A/G cg17807903 chr1:86174739 ZNHIT6 -0.5 -9.91 -0.48 2.02e-20 Urate levels in overweight individuals; CRC cis rs4713118 0.513 rs156738 chr6:28014025 G/C cg23161317 chr6:28129485 ZNF389 0.45 6.32 0.33 8.63e-10 Parkinson's disease; CRC cis rs868943 0.582 rs12209373 chr6:116488925 G/A cg15226275 chr6:116381976 FRK 0.27 6.06 0.32 3.64e-9 Total cholesterol levels; CRC cis rs11098499 0.954 rs1546505 chr4:120241224 A/G cg09307838 chr4:120376055 NA 0.68 10.35 0.5 6.44e-22 Corneal astigmatism; CRC cis rs6701037 0.782 rs12760073 chr1:175139295 G/T cg00321850 chr1:175162397 KIAA0040 -0.43 -7.05 -0.36 1.05e-11 Alcohol dependence; CRC trans rs35110281 0.774 rs1378080 chr21:45011315 T/A cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.46 7.45 0.38 8.46e-13 Mean corpuscular volume; CRC cis rs6681460 0.576 rs7354930 chr1:66986377 T/C cg02459107 chr1:67143332 SGIP1 0.36 5.62 0.3 4.16e-8 Presence of antiphospholipid antibodies; CRC cis rs6963495 0.818 rs73190151 chr7:105152887 C/T cg13798780 chr7:105162888 PUS7 0.67 7.93 0.4 3.42e-14 Bipolar disorder (body mass index interaction); CRC cis rs17401966 1.000 rs3753037 chr1:10355834 C/T cg19773385 chr1:10388646 KIF1B -0.57 -8.05 -0.41 1.55e-14 Hepatocellular carcinoma; CRC cis rs6912958 0.559 rs173333 chr6:88047754 T/G cg08069147 chr6:88032118 GJB7;C6orf162 0.69 11.09 0.52 1.7e-24 Monocyte percentage of white cells; CRC cis rs7223966 1.000 rs6504169 chr17:61709145 A/G cg05941027 chr17:61774174 LIMD2 0.34 6.27 0.33 1.15e-9 Hip circumference adjusted for BMI;Body mass index; CRC cis rs2342371 0.883 rs11185542 chr3:196187927 G/C cg15048948 chr3:196158458 UBXN7 -0.52 -5.78 -0.3 1.77e-8 Fat distribution (HIV); CRC cis rs995000 0.965 rs1690761 chr1:62955862 C/T cg19896129 chr1:63156450 NA -0.45 -6.98 -0.36 1.6e-11 Triglyceride levels; CRC trans rs2243480 1.000 rs1618893 chr7:66096119 C/T cg10756647 chr7:56101905 PSPH 0.67 6.83 0.35 4.13e-11 Diabetic kidney disease; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg09226173 chr5:122111107 SNX2 0.42 6.14 0.32 2.41e-9 Intelligence (multi-trait analysis); CRC cis rs8072100 0.713 rs11651643 chr17:45483229 A/G cg25173405 chr17:45401733 C17orf57 -0.43 -6.46 -0.34 3.83e-10 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs4363385 0.791 rs11205177 chr1:153002502 G/A cg25856811 chr1:152973957 SPRR3 -0.26 -7.16 -0.37 5.44e-12 Inflammatory skin disease; CRC cis rs9925964 0.967 rs9936329 chr16:31140799 G/T cg03418659 chr16:31128414 MYST1 0.54 7.86 0.4 5.55e-14 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs3740540 0.507 rs942014 chr10:126290070 C/T cg04949429 chr10:126290192 LHPP 0.44 6.5 0.34 2.93e-10 Obesity-related traits;Acute lymphoblastic leukemia (childhood); CRC cis rs2120019 0.938 rs2120020 chr15:75316845 T/C cg17294928 chr15:75287854 SCAMP5 -0.77 -11.09 -0.52 1.73e-24 Blood trace element (Zn levels); CRC cis rs6840360 0.967 rs10049728 chr4:152672121 C/G cg09659197 chr4:152720779 NA 0.52 11.41 0.53 1.28e-25 Intelligence (multi-trait analysis); CRC cis rs8067545 0.750 rs28603224 chr17:19985052 G/A cg13482628 chr17:19912719 NA 0.47 7.49 0.38 6.26e-13 Schizophrenia; CRC cis rs524281 0.731 rs2452682 chr11:65812609 C/T cg16950941 chr11:66035639 RAB1B -0.48 -5.76 -0.3 1.9e-8 Electroencephalogram traits; CRC cis rs68170813 0.599 rs12532514 chr7:107000952 C/T cg02696742 chr7:106810147 HBP1 -0.54 -5.87 -0.31 1.04e-8 Coronary artery disease; CRC cis rs2976388 0.566 rs4736373 chr8:143792357 G/C cg10596483 chr8:143751796 JRK -0.46 -6.43 -0.33 4.58e-10 Urinary tract infection frequency; CRC cis rs992157 0.764 rs4423579 chr2:219185033 G/T cg04880052 chr2:219191631 PNKD 0.4 6.1 0.32 3.01e-9 Colorectal cancer; CRC trans rs10504229 1.000 rs61998258 chr8:58192284 T/C cg04077850 chr5:125800366 GRAMD3 0.37 6.27 0.33 1.15e-9 Developmental language disorder (linguistic errors); CRC trans rs2303319 0.582 rs62187608 chr2:162431138 T/G cg10498984 chr16:28874827 SH2B1 -0.73 -5.98 -0.31 5.81e-9 Cognitive function; CRC cis rs12142240 0.698 rs58162700 chr1:46816659 T/A cg00530320 chr1:46809349 NSUN4 0.57 7.75 0.39 1.19e-13 Menopause (age at onset); CRC cis rs1320333 0.772 rs17786120 chr2:700580 A/T cg20966539 chr2:681320 NA 0.67 6.37 0.33 6.27e-10 Obesity-related traits; CRC cis rs3956705 0.798 rs1045477 chr7:32908704 T/C cg05721444 chr7:32995514 FKBP9 -0.44 -6.45 -0.34 3.92e-10 Red cell distribution width; CRC cis rs3857067 1.000 rs115969971 chr4:95023550 T/C cg11021082 chr4:95130006 SMARCAD1 -0.4 -6.05 -0.32 3.9e-9 QT interval; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg15617548 chr2:171785815 GORASP2 -0.42 -6.13 -0.32 2.49e-9 Myopia (pathological); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg24562565 chr11:27494352 LGR4 0.5 7.4 0.38 1.12e-12 Response to antipsychotic treatment; CRC cis rs4862750 0.872 rs7658314 chr4:187900356 T/C cg06074448 chr4:187884817 NA -0.6 -11.3 -0.53 2.95e-25 Lobe attachment (rater-scored or self-reported); CRC cis rs743757 1.000 rs2282752 chr3:50433967 G/C cg09545109 chr3:50388910 TUSC4;CYB561D2 0.44 6.42 0.33 4.73e-10 Diastolic blood pressure; CRC cis rs3733585 0.605 rs7656624 chr4:10121097 T/C cg00071950 chr4:10020882 SLC2A9 -0.59 -9.79 -0.47 5.1e-20 Cleft plate (environmental tobacco smoke interaction); CRC cis rs2463822 0.844 rs72923263 chr11:62161170 C/G cg06239285 chr11:62104954 ASRGL1 -0.92 -9.42 -0.46 8.4e-19 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs2153535 0.601 rs4140584 chr6:8540614 C/G cg07606381 chr6:8435919 SLC35B3 -0.68 -10.93 -0.52 6.36e-24 Motion sickness; CRC cis rs4272321 1 rs4272321 chr7:157951835 A/G cg22791324 chr7:157949174 PTPRN2 0.35 5.89 0.31 9.71e-9 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; CRC cis rs1153858 1.000 rs11070453 chr15:45645154 C/G cg21132104 chr15:45694354 SPATA5L1 0.59 8.66 0.43 2.14e-16 Homoarginine levels; CRC cis rs6748734 0.817 rs10182575 chr2:241806690 C/T cg16358738 chr2:241808595 AGXT -0.4 -6.24 -0.33 1.32e-9 Urinary metabolites; CRC cis rs7914558 1.000 rs7920251 chr10:104950197 C/T cg04362960 chr10:104952993 NT5C2 0.59 8.56 0.43 4.25e-16 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs9640161 0.617 rs56019796 chr7:150009226 T/C cg12556325 chr7:150026731 C7orf29;LRRC61 -0.39 -6.21 -0.32 1.61e-9 Blood protein levels;Circulating chemerin levels; CRC trans rs3780486 0.846 rs10971420 chr9:33125000 T/C cg04842962 chr6:43655489 MRPS18A 1.16 26.05 0.82 5.8e-82 IgG glycosylation; CRC trans rs853679 0.607 rs34950484 chr6:28278688 G/A cg06606381 chr12:133084897 FBRSL1 -1.44 -10.94 -0.52 5.61e-24 Depression; CRC cis rs12477438 0.765 rs17708262 chr2:99696313 T/A cg26064155 chr2:99771622 LIPT1;TSGA10 -0.63 -8.54 -0.43 5.03e-16 Chronic sinus infection; CRC cis rs798554 0.610 rs2644304 chr7:2878779 T/C cg19717773 chr7:2847554 GNA12 -0.42 -7.21 -0.37 3.83e-12 Height; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg00309650 chr4:88312547 HSD17B11 0.43 6.13 0.32 2.45e-9 Response to antipsychotic treatment; CRC cis rs1003719 0.762 rs1155786 chr21:38448025 A/G cg10648535 chr21:38446584 PIGP;TTC3 0.54 7.64 0.39 2.38e-13 Eye color traits; CRC cis rs10504229 0.724 rs16922734 chr8:58111192 C/T cg02290350 chr8:58132656 NA -0.6 -8.3 -0.42 2.8e-15 Developmental language disorder (linguistic errors); CRC cis rs3087591 0.708 rs3785956 chr17:29647707 C/A cg24425628 chr17:29625626 OMG;NF1 0.74 13.31 0.59 1.25e-32 Hip circumference; CRC cis rs9527 0.662 rs4919687 chr10:104595248 G/A cg04362960 chr10:104952993 NT5C2 0.65 8.34 0.42 2.04e-15 Arsenic metabolism; CRC cis rs13256369 1.000 rs10095733 chr8:8574646 A/G cg06636001 chr8:8085503 FLJ10661 0.44 5.75 0.3 2.05e-8 Obesity-related traits; CRC cis rs9372498 0.536 rs72952793 chr6:118892979 T/A cg22561889 chr6:118971681 C6orf204 0.46 5.77 0.3 1.87e-8 Diastolic blood pressure; CRC cis rs1552244 1.000 rs67852463 chr3:10157205 G/C cg02579736 chr3:10068473 FANCD2;CIDECP 1.05 13.74 0.6 2.86e-34 Alzheimer's disease; CRC cis rs230203 0.506 rs230195 chr20:55774426 C/A cg13236649 chr20:55835020 BMP7 0.41 6.02 0.31 4.67e-9 Monobrow; CRC cis rs10504229 1.000 rs114312649 chr8:58182539 C/G cg05313129 chr8:58192883 C8orf71 -0.47 -6.99 -0.36 1.49e-11 Developmental language disorder (linguistic errors); CRC cis rs10504229 1.000 rs112272435 chr8:58170371 A/G cg01721255 chr8:58191610 C8orf71 0.49 6.17 0.32 2e-9 Developmental language disorder (linguistic errors); CRC cis rs4654899 0.833 rs3816454 chr1:21191416 T/G cg02927042 chr1:21476669 EIF4G3 0.45 7.18 0.37 4.62e-12 Superior frontal gyrus grey matter volume; CRC trans rs2303319 0.504 rs62189047 chr2:162613314 T/A cg04551154 chr10:95462393 C10orf4 -0.75 -6.37 -0.33 6.43e-10 Cognitive function; CRC cis rs40363 0.680 rs4010628 chr16:3529779 G/A cg21433313 chr16:3507492 NAT15 0.6 5.63 0.3 3.85e-8 Tuberculosis; CRC cis rs9457247 1.000 rs389956 chr6:167407254 T/G cg23791538 chr6:167370224 RNASET2 -0.38 -5.94 -0.31 7.32e-9 Crohn's disease; CRC cis rs910316 0.967 rs4903293 chr14:75656568 A/G cg11812906 chr14:75593930 NEK9 -0.51 -7.56 -0.38 3.93e-13 Height; CRC cis rs9916302 0.706 rs9890198 chr17:37457480 A/C cg15445000 chr17:37608096 MED1 -0.33 -5.69 -0.3 2.83e-8 Glomerular filtration rate (creatinine); CRC cis rs950169 1.000 rs11638394 chr15:84778928 G/A cg11189052 chr15:85197271 WDR73 0.61 9.04 0.45 1.35e-17 Schizophrenia; CRC cis rs1005277 0.579 rs1780139 chr10:38503018 C/T cg25427524 chr10:38739819 LOC399744 -0.79 -14.49 -0.62 3.9e-37 Extrinsic epigenetic age acceleration; CRC cis rs4862750 0.872 rs6811837 chr4:187898162 G/A cg03647317 chr4:187891568 NA -0.54 -10.0 -0.48 9.71e-21 Lobe attachment (rater-scored or self-reported); CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg22251877 chr8:125551349 TATDN1;NDUFB9 -0.42 -6.39 -0.33 5.6e-10 Myopia (pathological); CRC cis rs1223397 0.938 rs9395602 chr6:13278753 C/T cg00460589 chr6:13274354 PHACTR1 0.49 6.03 0.32 4.33e-9 Blood pressure; CRC cis rs13108904 0.901 rs6851528 chr4:1296009 G/A cg21620606 chr4:1342894 KIAA1530 0.33 5.79 0.3 1.67e-8 Obesity-related traits; CRC cis rs9914988 0.943 rs4794839 chr17:27131393 G/A cg16670446 chr17:27188758 MIR451;MIR144 0.55 8.52 0.43 5.75e-16 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs9910055 0.529 rs575798 chr17:42181796 A/C cg13607699 chr17:42295918 UBTF -0.45 -5.82 -0.31 1.4e-8 Total body bone mineral density; CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg25595571 chr14:104029029 BAG5;C14orf153 0.37 6.09 0.32 3.09e-9 Obesity-related traits; CRC trans rs10504229 1.000 rs68112919 chr8:58188247 G/A cg04077850 chr5:125800366 GRAMD3 0.37 6.25 0.33 1.28e-9 Developmental language disorder (linguistic errors); CRC cis rs6662572 0.703 rs11580953 chr1:46387857 A/G cg03123370 chr1:45965343 CCDC163P;MMACHC 0.44 5.62 0.3 4.15e-8 Blood protein levels; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg23080178 chr12:52463740 C12orf44 0.46 6.4 0.33 5.22e-10 Anxiety disorder; CRC trans rs11148252 0.574 rs7139495 chr13:53283318 A/G cg18335740 chr13:41363409 SLC25A15 0.75 13.62 0.6 8.5e-34 Lewy body disease; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg01998682 chr6:151712546 ZBTB2 0.47 6.55 0.34 2.25e-10 Anxiety disorder; CRC cis rs35110281 0.693 rs2838345 chr21:45092715 C/T cg04455712 chr21:45112962 RRP1B 0.42 8.32 0.42 2.39e-15 Mean corpuscular volume; CRC cis rs9457247 0.602 rs17615336 chr6:167506734 A/G cg07513332 chr6:167530253 CCR6 0.35 5.63 0.3 3.87e-8 Crohn's disease; CRC trans rs12188164 0.686 rs72711369 chr5:420517 C/T cg15371732 chr17:78194151 SLC26A11;SGSH 0.45 6.29 0.33 1.04e-9 Cystic fibrosis severity; CRC cis rs11650494 0.710 rs76651802 chr17:47473785 A/G cg08112188 chr17:47440006 ZNF652 0.69 6.28 0.33 1.05e-9 Prostate cancer; CRC trans rs7267979 0.668 rs2387977 chr20:25599776 C/T cg17903999 chr18:56338584 MALT1 0.38 6.09 0.32 3.08e-9 Liver enzyme levels (alkaline phosphatase); CRC cis rs7959452 0.719 rs57954211 chr12:69748397 C/A cg14784868 chr12:69753453 YEATS4 0.8 13.08 0.59 8.83e-32 Blood protein levels; CRC cis rs13031619 0.517 rs10864995 chr2:3683557 C/T cg01268866 chr2:3683757 COLEC11 0.59 7.37 0.38 1.39e-12 Response to inhaled corticosteroid treatment in asthma (change in FEV1); CRC cis rs9911578 0.900 rs8067264 chr17:57182793 G/C cg05425664 chr17:57184151 TRIM37 -0.52 -8.3 -0.42 2.73e-15 Intelligence (multi-trait analysis); CRC cis rs780096 0.565 rs780104 chr2:27677691 G/A cg12000995 chr2:27665139 KRTCAP3 -0.32 -6.67 -0.35 1.1e-10 Total body bone mineral density; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg08938475 chr2:70313833 PCBP1 0.49 7.12 0.37 6.82e-12 Response to antipsychotic treatment; CRC cis rs7901135 1.000 rs9415589 chr10:60586802 A/T cg23799393 chr10:60588674 BICC1 0.36 5.66 0.3 3.26e-8 Morning vs. evening chronotype; CRC cis rs2280018 0.538 rs7404526 chr16:15129162 A/G cg27102117 chr16:15229624 NA 0.52 9.07 0.45 1.11e-17 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid);Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CRC cis rs9858542 0.953 rs9841110 chr3:49492481 C/G cg03060546 chr3:49711283 APEH -0.47 -6.56 -0.34 2.08e-10 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs5750830 0.594 rs1010169 chr22:39778167 C/T cg24399712 chr22:39784796 NA 0.45 8.8 0.44 8.12e-17 Intelligence (multi-trait analysis); CRC trans rs1413885 1.000 rs1413885 chr1:65815659 C/T cg26534493 chr8:28060551 NA -0.37 -5.98 -0.31 5.72e-9 Anticoagulant levels; CRC cis rs11690935 0.595 rs788166 chr2:172915489 G/C cg13550731 chr2:172543902 DYNC1I2 0.65 9.6 0.47 2.15e-19 Schizophrenia; CRC cis rs77956314 0.515 rs4767473 chr12:117365506 C/T cg25972092 chr12:117363249 FBXW8 0.52 6.1 0.32 2.95e-9 Subcortical brain region volumes;Hippocampal volume; CRC trans rs916888 0.697 rs199516 chr17:44856485 C/T cg22968622 chr17:43663579 NA -1.2 -15.67 -0.65 1.03e-41 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs7043114 0.525 rs10761161 chr9:95262342 C/G cg13798575 chr9:95087839 CENPP;NOL8 -0.42 -6.2 -0.32 1.65e-9 Height; CRC cis rs6942756 0.876 rs6953598 chr7:129033741 A/G cg02491457 chr7:128862824 NA 0.59 8.05 0.41 1.55e-14 White matter hyperintensity burden; CRC cis rs853679 0.546 rs34295134 chr6:27828151 T/A cg26587870 chr6:27730563 NA -0.59 -5.95 -0.31 6.85e-9 Depression; CRC cis rs6582630 0.555 rs11182217 chr12:38480030 G/A cg26384229 chr12:38710491 ALG10B 0.71 9.54 0.47 3.23e-19 Drug-induced liver injury (flucloxacillin); CRC cis rs3018066 0.666 rs10002288 chr4:106961604 A/C cg01869342 chr4:106983673 TBCK 0.49 6.27 0.33 1.17e-9 Cancer; CRC cis rs7918232 0.941 rs6482598 chr10:27426375 T/C cg14442939 chr10:27389572 ANKRD26 0.82 9.16 0.45 5.68e-18 Breast cancer; CRC cis rs9322193 0.847 rs9383844 chr6:150037404 T/C cg13206674 chr6:150067644 NUP43 0.67 10.09 0.49 4.73e-21 Lung cancer; CRC cis rs875971 0.862 rs9791712 chr7:66105163 C/G cg18252515 chr7:66147081 NA 0.42 5.95 0.31 7.03e-9 Aortic root size; CRC trans rs561341 0.556 rs542244 chr17:30307242 T/C cg27661571 chr11:113659931 NA -0.95 -11.14 -0.52 1.11e-24 Hip circumference adjusted for BMI; CRC cis rs6564851 0.506 rs11645428 chr16:81258896 C/T cg05274606 chr16:81253692 PKD1L2 -0.37 -6.07 -0.32 3.46e-9 Carotenoid and tocopherol levels; CRC cis rs2717559 0.542 rs2717586 chr8:143897882 C/T cg04969067 chr8:143858791 LYNX1 0.74 13.19 0.59 3.38e-32 Urinary tract infection frequency; CRC cis rs13098911 0.540 rs6780028 chr3:46075090 A/C cg12691230 chr3:46064611 XCR1 -0.52 -5.62 -0.3 4.01e-8 Celiac disease; CRC cis rs7937682 0.883 rs553632 chr11:111462897 C/T cg09085632 chr11:111637200 PPP2R1B -0.94 -17.74 -0.7 7.01e-50 Primary sclerosing cholangitis; CRC cis rs8062405 0.824 rs62034324 chr16:28536762 T/C cg05139728 chr16:28306816 SBK1 -0.33 -5.63 -0.3 3.77e-8 Cognitive ability (multi-trait analysis);Cognitive ability; CRC cis rs6088590 1.000 rs2295354 chr20:33356541 T/C cg24642439 chr20:33292090 TP53INP2 0.61 11.01 0.52 3.4e-24 Coronary artery disease; CRC cis rs3733585 0.699 rs4588456 chr4:9963895 A/T cg00071950 chr4:10020882 SLC2A9 -0.54 -9.65 -0.47 1.42e-19 Cleft plate (environmental tobacco smoke interaction); CRC trans rs1945213 0.694 rs7116741 chr11:55862620 C/T cg03929089 chr4:120376271 NA 0.59 6.66 0.34 1.17e-10 Acute lymphoblastic leukemia (childhood); CRC cis rs4789294 0.806 rs56239194 chr17:74403361 C/G cg06840243 chr17:74442338 UBE2O 0.43 6.05 0.32 3.87e-9 Lymphocyte percentage of white cells; CRC cis rs3096299 0.967 rs2911257 chr16:89484134 C/G cg01788221 chr16:89496183 ANKRD11 -0.47 -7.26 -0.37 2.79e-12 Multiple myeloma (IgH translocation); CRC cis rs4722166 0.695 rs6946509 chr7:22809490 T/C cg26061582 chr7:22766209 IL6 0.52 8.13 0.41 8.99e-15 Lung cancer; CRC cis rs875971 1.000 rs11974219 chr7:65647410 C/T cg18912574 chr7:65842487 NCRNA00174 -0.38 -6.57 -0.34 1.98e-10 Aortic root size; CRC cis rs711245 0.518 rs11886145 chr2:36825716 C/G cg09467607 chr2:36825704 FEZ2 0.78 14.62 0.63 1.2e-37 Height; CRC cis rs7412746 0.658 rs72704652 chr1:150819470 A/G cg10589385 chr1:150898437 SETDB1 0.32 6.55 0.34 2.2e-10 Melanoma; CRC cis rs6740322 0.895 rs9309097 chr2:43554397 T/A cg06169590 chr2:43455088 ZFP36L2;LOC100129726 -0.62 -7.56 -0.38 4.08e-13 Coronary artery disease; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg24098516 chr3:122233880 KPNA1 0.4 6.25 0.33 1.27e-9 Liver disease severity in Alagille syndrome; CRC cis rs9814567 0.929 rs9815297 chr3:134215052 A/G cg06541857 chr3:134203789 ANAPC13;CEP63 -0.39 -5.78 -0.3 1.75e-8 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs780096 0.526 rs780106 chr2:27681598 A/C cg24768116 chr2:27665128 KRTCAP3 -0.36 -8.12 -0.41 9.76e-15 Total body bone mineral density; CRC cis rs1192419 0.502 rs10493854 chr1:92055866 C/T cg24006770 chr1:92056542 NA -0.55 -9.26 -0.45 2.74e-18 Optic disc area;Optic nerve measurement (cup-to-disc ratio); CRC cis rs4409675 0.548 rs1000432 chr1:28225119 T/C cg23691781 chr1:28212827 C1orf38 0.31 7.15 0.37 5.72e-12 Corneal astigmatism; CRC cis rs7586879 0.796 rs36071142 chr2:25080570 C/T cg22495460 chr2:25135724 ADCY3 -0.82 -13.57 -0.6 1.31e-33 Body mass index; CRC cis rs6582630 0.562 rs35080195 chr12:38310866 G/A cg26384229 chr12:38710491 ALG10B -0.53 -7.55 -0.38 4.29e-13 Drug-induced liver injury (flucloxacillin); CRC cis rs9291683 0.588 rs6857693 chr4:10018435 G/A cg11266682 chr4:10021025 SLC2A9 0.54 11.57 0.54 3.2e-26 Bone mineral density; CRC cis rs651907 0.535 rs12633089 chr3:101528763 C/T cg11279151 chr3:101281821 RG9MTD1 -0.53 -7.17 -0.37 5.09e-12 Colorectal cancer; CRC cis rs9322193 0.923 rs9688861 chr6:149959060 G/T cg13206674 chr6:150067644 NUP43 0.64 9.69 0.47 1.04e-19 Lung cancer; CRC cis rs9902453 0.933 rs7225462 chr17:28321226 G/A cg26525008 chr17:28256777 EFCAB5;SSH2 0.68 11.06 0.52 2.17e-24 Coffee consumption (cups per day); CRC cis rs8062405 1.000 rs55830740 chr16:28847149 G/C cg08761264 chr16:28874980 SH2B1 -0.42 -5.64 -0.3 3.73e-8 Cognitive ability (multi-trait analysis);Cognitive ability; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg18121669 chr1:26560928 CCDC21 0.45 6.14 0.32 2.32e-9 Anxiety disorder; CRC cis rs6502050 0.731 rs9891378 chr17:80116035 T/C cg25804541 chr17:80189381 SLC16A3 -0.3 -5.88 -0.31 9.83e-9 Life satisfaction; CRC trans rs7647973 0.667 rs6446286 chr3:49681704 A/G cg21665057 chr3:196295764 WDR53;FBXO45 -0.68 -7.46 -0.38 7.88e-13 Menarche (age at onset); CRC cis rs7809950 0.954 rs2520247 chr7:107143946 A/T cg23024343 chr7:107201750 COG5 -0.6 -8.58 -0.43 3.85e-16 Coronary artery disease; CRC trans rs10982213 0.830 rs2274163 chr9:117188714 C/T cg14993530 chr1:245027115 HNRNPU 0.41 6.47 0.34 3.59e-10 Interleukin-6 levels; CRC cis rs9325144 0.600 rs12227663 chr12:38734922 C/T cg13010199 chr12:38710504 ALG10B -0.43 -6.14 -0.32 2.42e-9 Morning vs. evening chronotype; CRC cis rs6834538 0.637 rs11937201 chr4:113427458 A/G cg10021238 chr4:113569128 MIR367;LARP7 -0.41 -6.16 -0.32 2.14e-9 Free thyroxine concentration; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg06349174 chr11:3877476 STIM1 0.45 6.06 0.32 3.66e-9 Thyroid stimulating hormone; CRC cis rs7923609 0.934 rs10761763 chr10:65188318 T/C cg08743896 chr10:65200160 JMJD1C -0.42 -6.12 -0.32 2.62e-9 Educational attainment;Liver enzyme levels (alkaline phosphatase); CRC cis rs9322193 0.923 rs9800871 chr6:149965676 A/G cg07701084 chr6:150067640 NUP43 0.56 8.2 0.41 5.58e-15 Lung cancer; CRC cis rs873946 0.564 rs2803991 chr10:134557068 A/G cg27286337 chr10:134555280 INPP5A 0.75 10.24 0.49 1.47e-21 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CRC cis rs2066819 1.000 rs117683816 chr12:56638267 T/C cg26714650 chr12:56694279 CS -1.41 -11.64 -0.54 1.88e-26 Psoriasis vulgaris; CRC cis rs12760731 0.565 rs34303391 chr1:178178126 T/A cg00404053 chr1:178313656 RASAL2 1.05 10.96 0.52 4.8e-24 Obesity-related traits; CRC cis rs2011503 0.769 rs72999059 chr19:19378245 A/C cg11584989 chr19:19387371 SF4 0.6 6.76 0.35 6.25e-11 Bipolar disorder; CRC cis rs1552244 0.872 rs35988239 chr3:10074145 G/T cg00166722 chr3:10149974 C3orf24 0.72 8.26 0.41 3.63e-15 Alzheimer's disease; CRC cis rs6570726 1.000 rs6570699 chr6:145920732 G/A cg05347473 chr6:146136440 FBXO30 0.4 6.06 0.32 3.71e-9 Lobe attachment (rater-scored or self-reported); CRC trans rs1005277 0.579 rs2505197 chr10:38393310 T/C cg11292332 chr7:45801988 SEPT13 -0.35 -6.26 -0.33 1.18e-9 Extrinsic epigenetic age acceleration; CRC cis rs7666738 0.830 rs6846739 chr4:99016647 G/A cg17366294 chr4:99064904 C4orf37 0.43 7.28 0.37 2.52e-12 Colonoscopy-negative controls vs population controls; CRC cis rs4713118 0.568 rs9468213 chr6:27706180 G/A cg06470822 chr6:28175283 NA 0.62 8.81 0.44 7.28e-17 Parkinson's disease; CRC cis rs344364 0.511 rs2982452 chr16:1949511 G/A cg03013636 chr16:1946785 NA 0.58 7.08 0.36 8.69e-12 Glomerular filtration rate in chronic kidney disease; CRC cis rs854765 0.624 rs9899634 chr17:17727943 A/T cg09796270 chr17:17721594 SREBF1 -0.58 -10.2 -0.49 2.03e-21 Total body bone mineral density; CRC cis rs2708977 0.637 rs675239 chr2:97076556 A/G cg23100626 chr2:96804247 ASTL 0.22 5.62 0.3 4.09e-8 Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes; CRC cis rs11955398 0.625 rs11745077 chr5:59955716 C/T cg02684056 chr5:59996105 DEPDC1B 0.4 5.69 0.3 2.74e-8 Intelligence (multi-trait analysis); CRC cis rs2839186 0.656 rs8128380 chr21:47665693 C/T cg12516959 chr21:47718080 NA -0.39 -6.63 -0.34 1.37e-10 Testicular germ cell tumor; CRC cis rs73058052 0.569 rs2116922 chr19:50103252 G/A cg15963326 chr19:50037085 RCN3 -0.37 -5.96 -0.31 6.58e-9 Fibrinogen levels; CRC cis rs2976388 1.000 rs2920293 chr8:143765414 C/G cg20041105 chr8:143859282 LYNX1 -0.33 -5.76 -0.3 1.97e-8 Urinary tract infection frequency; CRC cis rs10504229 0.728 rs17804750 chr8:58155751 T/C cg21724239 chr8:58056113 NA 0.62 8.38 0.42 1.51e-15 Developmental language disorder (linguistic errors); CRC cis rs67311347 1.000 rs6793596 chr3:40457795 C/T cg09455208 chr3:40491958 NA 0.49 9.29 0.46 2.15e-18 Renal cell carcinoma; CRC cis rs9814567 1.000 rs4974493 chr3:134219993 C/T cg06541857 chr3:134203789 ANAPC13;CEP63 -0.4 -6.01 -0.31 4.88e-9 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs6968419 0.747 rs1000966 chr7:115862902 A/G cg02561103 chr7:115862891 TES -0.43 -6.47 -0.34 3.58e-10 Intraocular pressure; CRC cis rs4713118 0.513 rs149962 chr6:28015918 G/A cg20615401 chr6:28092323 ZSCAN16 0.46 6.16 0.32 2.14e-9 Parkinson's disease; CRC cis rs6694672 0.867 rs7513826 chr1:197150638 A/G cg13682187 chr1:196946512 CFHR5 0.51 7.66 0.39 2.06e-13 Asthma; CRC cis rs9814567 1.000 rs9841212 chr3:134191938 C/T cg06109529 chr3:134205091 CEP63;ANAPC13 -0.74 -10.52 -0.5 1.6400000000000001e-22 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs2797160 1.000 rs2747722 chr6:126009629 A/G cg05901451 chr6:126070800 HEY2 0.4 6.2 0.32 1.65e-9 Endometrial cancer; CRC cis rs7208859 0.623 rs77009951 chr17:29080650 T/C cg01831904 chr17:28903510 LRRC37B2 -0.62 -6.41 -0.33 5.05e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs6546324 0.625 rs6546317 chr2:67828793 C/G cg15745817 chr2:67799979 NA -0.54 -9.04 -0.45 1.4e-17 Endometriosis; CRC cis rs977987 0.806 rs2161684 chr16:75479153 T/C cg03315344 chr16:75512273 CHST6 0.57 9.7 0.47 9.94e-20 Dupuytren's disease; CRC cis rs908922 0.651 rs1572534 chr1:152509689 G/A cg09873164 chr1:152488093 CRCT1 0.38 6.34 0.33 7.62e-10 Hair morphology; CRC cis rs4843747 0.641 rs11117353 chr16:88090895 A/G cg17633681 chr16:88106987 BANP 0.82 13.96 0.61 4.35e-35 Menopause (age at onset); CRC cis rs8180040 0.903 rs11130124 chr3:47292183 T/C cg27129171 chr3:47204927 SETD2 0.72 12.03 0.55 7.27e-28 Colorectal cancer; CRC cis rs921968 0.541 rs7604319 chr2:219538799 A/C cg02176678 chr2:219576539 TTLL4 -0.61 -9.54 -0.47 3.39e-19 Mean corpuscular hemoglobin concentration; CRC cis rs9902453 0.933 rs2054846 chr17:28507693 A/G cg26525008 chr17:28256777 EFCAB5;SSH2 -0.56 -8.51 -0.42 6.46e-16 Coffee consumption (cups per day); CRC cis rs12431939 0.947 rs55974960 chr14:51633742 T/C cg23942311 chr14:51606299 NA -0.55 -6.05 -0.32 3.96e-9 Cancer; CRC cis rs13118159 0.801 rs7664474 chr4:1329116 T/A cg20887711 chr4:1340912 KIAA1530 0.41 5.72 0.3 2.46e-8 Longevity; CRC cis rs1003719 0.751 rs10154032 chr21:38453459 T/C cg10648535 chr21:38446584 PIGP;TTC3 0.52 7.31 0.37 2.04e-12 Eye color traits; CRC cis rs9910055 0.529 rs408282 chr17:42182267 A/G cg10896456 chr17:42255109 ASB16;C17orf65 -0.37 -5.68 -0.3 2.96e-8 Total body bone mineral density; CRC cis rs17270561 0.609 rs9379788 chr6:25742759 A/C cg17691542 chr6:26056736 HIST1H1C 0.72 9.24 0.45 3.07e-18 Iron status biomarkers; CRC trans rs11673344 0.528 rs476194 chr19:37410733 T/C cg18947437 chr10:1231002 ADARB2 -0.35 -6.28 -0.33 1.06e-9 Obesity-related traits; CRC cis rs1005277 0.563 rs2505216 chr10:38482830 T/C cg25427524 chr10:38739819 LOC399744 -0.77 -13.75 -0.6 2.69e-34 Extrinsic epigenetic age acceleration; CRC cis rs6598955 0.724 rs12096059 chr1:26596709 G/A cg04990556 chr1:26633338 UBXN11 -0.79 -13.35 -0.59 8.41e-33 Obesity-related traits; CRC cis rs7113874 0.569 rs11041983 chr11:8580619 A/G cg17679104 chr11:8615758 STK33 -0.35 -5.84 -0.31 1.23e-8 Body mass index in physically active individuals;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs4974559 0.501 rs900013 chr4:1240450 G/A cg02980000 chr4:1222292 CTBP1 -0.73 -8.36 -0.42 1.76e-15 Systolic blood pressure; CRC cis rs3540 0.574 rs2657947 chr15:90968977 C/T cg22089800 chr15:90895588 ZNF774 -0.53 -8.8 -0.44 8.04e-17 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; CRC cis rs6912958 1.000 rs2223880 chr6:88167897 C/T cg08069147 chr6:88032118 GJB7;C6orf162 -0.63 -9.7 -0.47 9.86e-20 Monocyte percentage of white cells; CRC trans rs10842750 1.000 rs10842750 chr12:26690565 G/T cg01662769 chr14:64932348 AKAP5 0.5 6.06 0.32 3.65e-9 Kashin-Beck disease; CRC cis rs7412746 0.622 rs72704654 chr1:150826410 G/A cg18016565 chr1:150552671 MCL1 0.44 6.04 0.32 4.07e-9 Melanoma; CRC cis rs801193 0.569 rs7782587 chr7:66166472 C/T cg18876405 chr7:65276391 NA 0.51 8.26 0.41 3.55e-15 Aortic root size; CRC cis rs3741151 1.000 rs7949364 chr11:73041077 A/G cg17517138 chr11:73019481 ARHGEF17 0.67 7.03 0.36 1.21e-11 GIP levels in response to oral glucose tolerance test (120 minutes); CRC cis rs7312933 1.000 rs12372597 chr12:42412850 C/T cg11827402 chr12:42719852 PPHLN1;ZCRB1 0.61 7.76 0.39 1.11e-13 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CRC cis rs477895 0.713 rs7952318 chr11:63961242 G/A cg04317338 chr11:64019027 PLCB3 0.54 6.72 0.35 7.95e-11 Mean platelet volume; CRC cis rs9992667 0.955 rs28560778 chr4:38611289 G/A cg19726192 chr4:38663646 FLJ13197 -0.59 -7.54 -0.38 4.61e-13 Eosinophil percentage of granulocytes; CRC cis rs4713118 0.955 rs9393848 chr6:27688369 C/T cg15786705 chr6:28176104 NA 0.49 6.62 0.34 1.45e-10 Parkinson's disease; CRC cis rs11123170 0.543 rs4849180 chr2:113985186 C/G cg12889195 chr2:113992843 PAX8;LOC440839;LOC654433 0.5 5.91 0.31 8.45e-9 Renal function-related traits (BUN); CRC trans rs28673968 0.615 rs1603250 chr4:90513906 C/T cg18438894 chr1:184377525 C1orf21 0.38 5.97 0.31 6.31e-9 Idiopathic pulmonary fibrosis; CRC cis rs7799006 0.895 rs3757437 chr7:2271980 C/T cg08027265 chr7:2291960 NA -0.43 -6.62 -0.34 1.47e-10 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC trans rs2727020 0.636 rs10839275 chr11:49438962 T/A cg15704280 chr7:45808275 SEPT13 -0.91 -17.24 -0.69 6.89e-48 Coronary artery disease; CRC trans rs11764590 0.671 rs62444906 chr7:2083161 G/T cg11693508 chr17:37793320 STARD3 0.58 6.73 0.35 7.63e-11 Neuroticism; CRC cis rs7772486 0.597 rs9285508 chr6:146262697 G/T cg23711669 chr6:146136114 FBXO30 -0.61 -8.18 -0.41 6.29e-15 Lobe attachment (rater-scored or self-reported); CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg14258675 chr14:75348443 DLST 0.51 6.74 0.35 6.92e-11 Thyroid stimulating hormone; CRC cis rs1401999 0.934 rs1132776 chr3:183696402 A/G cg20387954 chr3:183756860 HTR3D 0.42 7.17 0.37 5.04e-12 Anterior chamber depth; CRC cis rs9308731 0.623 rs11674517 chr2:111903832 C/T cg04202892 chr2:111875749 ACOXL 0.46 7.5 0.38 6.02e-13 Chronic lymphocytic leukemia; CRC cis rs6964587 0.869 rs55811257 chr7:91484799 T/A cg17063962 chr7:91808500 NA -0.72 -12.19 -0.56 1.83e-28 Breast cancer; CRC cis rs40363 0.645 rs1690449 chr16:3520893 C/G cg05754148 chr16:3507555 NAT15 0.44 6.15 0.32 2.3e-9 Tuberculosis; CRC cis rs2197308 0.765 rs2387436 chr12:37935337 C/T cg13010199 chr12:38710504 ALG10B -0.49 -7.23 -0.37 3.45e-12 Morning vs. evening chronotype; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg20441175 chr10:75007251 DNAJC9 0.5 7.35 0.38 1.57e-12 Intelligence (multi-trait analysis); CRC cis rs9611565 0.559 rs1006407 chr22:41972032 T/C cg03806693 chr22:41940476 POLR3H -1.03 -11.25 -0.53 4.77e-25 Vitiligo; CRC cis rs7178572 0.568 rs11854193 chr15:77458136 C/A cg22256960 chr15:77711686 NA -0.66 -9.41 -0.46 8.66e-19 Type 2 diabetes; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg09311052 chr1:154531418 UBE2Q1 0.44 6.16 0.32 2.16e-9 Response to antipsychotic treatment; CRC cis rs7259376 0.818 rs8101997 chr19:22568432 A/T cg02657401 chr19:22469223 NA -0.33 -7.24 -0.37 3.3e-12 Menopause (age at onset); CRC cis rs13191362 0.507 rs1954806 chr6:163051858 G/C cg06582575 chr6:163149167 PACRG;PARK2 -0.57 -8.49 -0.42 7.44e-16 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs10411161 0.702 rs6509592 chr19:52393150 G/A cg11269599 chr19:52391304 ZNF577 0.52 6.31 0.33 9.09e-10 Breast cancer; CRC cis rs7647973 0.516 rs4536858 chr3:49193081 A/G cg03060546 chr3:49711283 APEH 0.4 5.67 0.3 3.1e-8 Menarche (age at onset); CRC cis rs6598955 0.543 rs3795689 chr1:26560366 C/G cg04990556 chr1:26633338 UBXN11 0.83 10.52 0.5 1.73e-22 Obesity-related traits; CRC trans rs11039798 0.588 rs11039807 chr11:48549391 T/A cg15704280 chr7:45808275 SEPT13 0.66 7.02 0.36 1.27e-11 Axial length; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg12977448 chr10:14920832 SUV39H2 0.49 7.55 0.38 4.19e-13 Intelligence (multi-trait analysis); CRC cis rs9549367 0.569 rs3024719 chr13:113814225 G/A cg00898013 chr13:113819073 PROZ -0.5 -6.33 -0.33 8.09e-10 Platelet distribution width; CRC cis rs4908760 0.860 rs11121202 chr1:8639357 T/C cg20416874 chr1:8611966 RERE -0.43 -6.15 -0.32 2.28e-9 Vitiligo; CRC cis rs593982 1.000 rs56257941 chr11:65505641 C/T cg08755490 chr11:65554678 OVOL1 -1.08 -12.43 -0.57 2.49e-29 Atopic dermatitis; CRC trans rs12803066 0.505 rs17697327 chr11:99978855 A/G cg22457238 chr19:58570995 ZNF135 -0.45 -6.03 -0.32 4.29e-9 Myopia (pathological); CRC cis rs2836974 0.897 rs14194 chr21:40549466 T/C cg17971929 chr21:40555470 PSMG1 0.82 11.69 0.54 1.28e-26 Cognitive function; CRC trans rs561341 0.882 rs72825748 chr17:30367396 G/A cg27661571 chr11:113659931 NA -0.95 -11.09 -0.52 1.65e-24 Hip circumference adjusted for BMI; CRC cis rs10924970 0.967 rs10802617 chr1:235485768 C/T cg26050004 chr1:235667680 B3GALNT2 0.41 6.12 0.32 2.66e-9 Asthma; CRC cis rs6424115 0.830 rs2501423 chr1:24199026 A/C cg15997130 chr1:24165203 NA 0.72 10.64 0.51 6.66e-23 Immature fraction of reticulocytes; CRC cis rs7605827 0.930 rs2380652 chr2:15594926 T/C cg19274914 chr2:15703543 NA 0.39 6.03 0.32 4.51e-9 Educational attainment (years of education); CRC cis rs1005277 0.579 rs2472183 chr10:38392495 T/G cg00409905 chr10:38381863 ZNF37A -0.68 -11.32 -0.53 2.64e-25 Extrinsic epigenetic age acceleration; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg24533757 chr11:36615953 RAG2;C11orf74 0.4 6.18 0.32 1.87e-9 Liver disease severity in Alagille syndrome; CRC cis rs4713118 0.513 rs149962 chr6:28015918 G/A cg18032046 chr6:28092343 ZSCAN16 -0.43 -5.87 -0.31 1.05e-8 Parkinson's disease; CRC cis rs2243480 1.000 rs4718315 chr7:65648541 T/C cg12463550 chr7:65579703 CRCP -0.71 -6.52 -0.34 2.61e-10 Diabetic kidney disease; CRC cis rs9326248 1.000 rs4938354 chr11:117051165 A/G cg11861562 chr11:117069780 TAGLN 0.41 9.37 0.46 1.17e-18 Blood protein levels; CRC cis rs7647973 0.626 rs12715437 chr3:49751856 T/C cg13072238 chr3:49761600 GMPPB -0.48 -5.63 -0.3 3.86e-8 Menarche (age at onset); CRC cis rs11809207 0.523 rs2783628 chr1:26501827 A/C cg00147160 chr1:26503991 CNKSR1 0.29 6.08 0.32 3.25e-9 Height; CRC trans rs7615952 0.688 rs7624806 chr3:125599074 G/A cg07211511 chr3:129823064 LOC729375 -1.11 -17.4 -0.69 1.56e-48 Blood pressure (smoking interaction); CRC cis rs6484504 0.576 rs208071 chr11:31144996 C/T cg14844989 chr11:31128820 NA -0.34 -5.9 -0.31 8.79e-9 Red blood cell count; CRC cis rs17376456 0.825 rs13182631 chr5:93115701 A/G cg25358565 chr5:93447407 FAM172A 1.0 9.49 0.46 4.89e-19 Diabetic retinopathy; CRC cis rs2115630 0.846 rs8024538 chr15:85368419 A/T cg09876464 chr15:85330779 ZNF592 0.42 6.83 0.35 4.21e-11 P wave terminal force; CRC cis rs9910055 0.529 rs368328 chr17:42170289 G/A cg13607699 chr17:42295918 UBTF -0.5 -6.6 -0.34 1.68e-10 Total body bone mineral density; CRC cis rs939584 0.932 rs2867108 chr2:650143 T/C cg03610516 chr2:642275 NA -0.42 -5.89 -0.31 9.71e-9 Body mass index; CRC cis rs853679 0.550 rs1150692 chr6:28173957 A/G cg25164649 chr6:28176230 NA 0.77 10.66 0.51 5.59e-23 Depression; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg03175635 chr2:203736521 ICA1L 0.4 6.17 0.32 2e-9 Intelligence (multi-trait analysis); CRC cis rs9470366 0.509 rs4713996 chr6:36629714 C/T cg08179530 chr6:36648295 CDKN1A -0.55 -7.97 -0.4 2.59e-14 QRS duration; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg26248908 chr17:4614115 ARRB2 0.37 6.12 0.32 2.67e-9 Liver disease severity in Alagille syndrome; CRC cis rs4700695 0.841 rs27132 chr5:65288791 A/G cg21114390 chr5:65439923 SFRS12 0.56 6.95 0.36 2.02e-11 Facial morphology (factor 19); CRC cis rs7481584 0.581 rs399565 chr11:3061780 C/T cg25174290 chr11:3078921 CARS -0.42 -5.88 -0.31 9.9e-9 Calcium levels; CRC cis rs9443645 0.527 rs1413968 chr6:79791042 A/G cg09184832 chr6:79620586 NA -0.43 -7.32 -0.37 1.87e-12 Intelligence (multi-trait analysis); CRC cis rs7937682 0.924 rs10891288 chr11:111552053 G/T cg09085632 chr11:111637200 PPP2R1B 1.0 20.66 0.75 2.3e-61 Primary sclerosing cholangitis; CRC cis rs11690935 0.632 rs35854151 chr2:172657439 G/A cg13550731 chr2:172543902 DYNC1I2 0.68 9.95 0.48 1.42e-20 Schizophrenia; CRC trans rs4843747 0.671 rs8053377 chr16:88106465 A/G cg26811252 chr16:29126840 RRN3P2 0.61 8.31 0.42 2.62e-15 Menopause (age at onset); CRC cis rs853679 0.517 rs9368558 chr6:28133306 A/G cg18032046 chr6:28092343 ZSCAN16 -0.51 -5.93 -0.31 7.47e-9 Depression; CRC cis rs734999 0.545 rs12749591 chr1:2563250 G/T cg18854424 chr1:2615690 NA -0.5 -9.87 -0.48 2.73e-20 Ulcerative colitis; CRC cis rs9309711 0.666 rs6723126 chr2:3484500 T/C cg10845886 chr2:3471009 TTC15 -0.4 -6.33 -0.33 7.99e-10 Neurofibrillary tangles; CRC cis rs12913538 0.862 rs1550053 chr15:62890532 G/C cg09983546 chr15:62884068 NA 0.5 7.79 0.39 8.95e-14 Sleep depth; CRC trans rs10838798 0.584 rs1566732 chr11:48151494 A/C cg15704280 chr7:45808275 SEPT13 0.44 5.99 0.31 5.47e-9 Height; CRC cis rs6973256 0.569 rs13246174 chr7:133395004 C/T cg10665199 chr7:133106180 EXOC4 0.48 7.53 0.38 4.98e-13 Intelligence (multi-trait analysis); CRC cis rs1882538 0.569 rs11562036 chr7:133076862 T/C cg10665199 chr7:133106180 EXOC4 0.69 10.65 0.51 5.73e-23 Intelligence (multi-trait analysis); CRC cis rs4853012 0.838 rs72915068 chr2:74356185 G/A cg01017244 chr2:74357527 NA 0.75 10.14 0.49 3.41e-21 Gestational age at birth (maternal effect); CRC cis rs78545713 0.649 rs11757549 chr6:26231608 G/A cg01420254 chr6:26195488 NA 0.66 5.87 0.31 1.08e-8 Iron status biomarkers (total iron binding capacity); CRC cis rs6460942 0.505 rs73055515 chr7:12328804 A/G cg20607287 chr7:12443886 VWDE -0.56 -6.04 -0.32 4.1e-9 Coronary artery disease; CRC cis rs873946 0.648 rs12767126 chr10:134556992 C/T cg06453172 chr10:134556979 INPP5A -0.67 -7.86 -0.4 5.54e-14 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CRC cis rs7618915 0.547 rs1561337 chr3:52659963 C/T cg11645453 chr3:52864694 ITIH4 0.33 5.82 0.31 1.37e-8 Bipolar disorder; CRC cis rs4253772 0.591 rs9615343 chr22:46690824 C/G cg24881330 chr22:46731750 TRMU 0.59 5.74 0.3 2.2e-8 LDL cholesterol;Cholesterol, total; CRC cis rs9942416 0.660 rs193344 chr5:74977854 T/C cg00601450 chr5:74908170 NA -0.37 -5.63 -0.3 3.82e-8 Age-related disease endophenotypes; CRC cis rs7615952 0.576 rs12497295 chr3:125818650 G/A cg02772935 chr3:125709198 NA -0.49 -5.68 -0.3 2.91e-8 Blood pressure (smoking interaction); CRC cis rs6952808 0.723 rs57216949 chr7:2030287 G/T cg04267008 chr7:1944627 MAD1L1 -0.78 -11.31 -0.53 2.92e-25 Bipolar disorder and schizophrenia; CRC cis rs72781680 0.611 rs72781695 chr2:24266744 T/C cg20701182 chr2:24300061 SF3B14 0.59 6.69 0.35 9.34e-11 Lymphocyte counts; CRC cis rs9787249 0.957 rs6670841 chr1:40220284 C/G cg19912559 chr1:40204330 PPIE 0.53 7.86 0.4 5.49e-14 Blood protein levels; CRC cis rs6988985 0.703 rs4736312 chr8:143953937 A/C cg10324643 chr8:143916377 GML 0.35 5.84 0.31 1.23e-8 Plasma androstenedione levels in resected early stage-receptor positive breast cancer; CRC cis rs11148252 0.904 rs9568732 chr13:52993412 A/G cg00495681 chr13:53174319 NA -0.65 -10.28 -0.49 1.08e-21 Lewy body disease; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg05478295 chr8:61429204 RAB2A 0.4 6.42 0.33 4.76e-10 Liver disease severity in Alagille syndrome; CRC cis rs2549003 1.000 rs2706384 chr5:131826880 G/T cg00255919 chr5:131827918 IRF1 -0.59 -11.53 -0.54 4.46e-26 Asthma (sex interaction); CRC cis rs7725052 0.609 rs4957300 chr5:40463739 C/T cg09067459 chr5:40385259 NA -0.38 -6.29 -0.33 9.85e-10 Pediatric autoimmune diseases; CRC cis rs651907 0.557 rs7651721 chr3:101393583 C/A cg12386194 chr3:101231763 SENP7 0.51 7.32 0.37 1.97e-12 Colorectal cancer; CRC cis rs853679 0.517 rs56364346 chr6:28050762 T/G cg12172441 chr6:28176163 NA 0.6 7.2 0.37 4.23e-12 Depression; CRC cis rs4713118 0.513 rs9368547 chr6:28028067 A/G cg10876282 chr6:28092338 ZSCAN16 0.49 6.5 0.34 2.92e-10 Parkinson's disease; CRC cis rs432925 0.600 rs214247 chr16:349221 A/G cg06233593 chr16:337645 AXIN1 0.58 9.24 0.45 3.06e-18 Morning vs. evening chronotype; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg03442064 chr6:41515050 FOXP4 0.51 7.2 0.37 4.07e-12 Response to antipsychotic treatment; CRC cis rs76878669 0.561 rs905770 chr11:66156765 A/G cg24851651 chr11:66362959 CCS -0.35 -5.8 -0.3 1.59e-8 Educational attainment (years of education); CRC cis rs9398803 0.865 rs4565329 chr6:126752798 A/G cg19875578 chr6:126661172 C6orf173 -0.42 -5.83 -0.31 1.34e-8 Male-pattern baldness; CRC cis rs62064224 0.791 rs2344977 chr17:30720573 C/G cg09324608 chr17:30823087 MYO1D 0.39 6.06 0.32 3.72e-9 Schizophrenia; CRC cis rs2836974 0.644 rs2836982 chr21:40689171 C/A cg06238570 chr21:40685208 BRWD1 -0.82 -12.95 -0.58 2.81e-31 Cognitive function; CRC cis rs17270561 0.609 rs1179086 chr6:25791745 A/T cg16482183 chr6:26056742 HIST1H1C 0.6 8.12 0.41 9.28e-15 Iron status biomarkers; CRC cis rs12142240 0.698 rs56358525 chr1:46849520 C/T cg00530320 chr1:46809349 NSUN4 0.59 8.01 0.4 1.95e-14 Menopause (age at onset); CRC cis rs72781680 0.898 rs12614616 chr2:23996501 T/G cg08917208 chr2:24149416 ATAD2B 0.86 8.35 0.42 1.86e-15 Lymphocyte counts; CRC cis rs6912958 0.514 rs1980792 chr6:87889917 A/G cg04972856 chr6:88032051 C6orf162;GJB7 -0.32 -6.01 -0.31 4.87e-9 Monocyte percentage of white cells; CRC cis rs13082711 0.558 rs640912 chr3:27364092 C/A cg02860705 chr3:27208620 NA 0.5 7.36 0.38 1.5e-12 Systolic blood pressure;Diastolic blood pressure;Blood pressure; CRC cis rs61008539 0.815 rs6960062 chr7:884665 A/G cg00934597 chr7:893267 UNC84A -0.53 -7.28 -0.37 2.42e-12 Perceived unattractiveness to mosquitoes; CRC cis rs10461617 0.617 rs1423623 chr5:56065575 A/G cg20203395 chr5:56204925 C5orf35 0.5 6.5 0.34 2.91e-10 Type 2 diabetes; CRC cis rs9326248 0.953 rs634960 chr11:117072963 T/C cg11861562 chr11:117069780 TAGLN -0.42 -9.31 -0.46 1.9e-18 Blood protein levels; CRC cis rs11098499 0.955 rs13113112 chr4:120156040 C/T cg09307838 chr4:120376055 NA 0.65 9.95 0.48 1.41e-20 Corneal astigmatism; CRC cis rs8105895 0.935 rs7251884 chr19:22245530 C/T cg02657401 chr19:22469223 NA -0.34 -5.65 -0.3 3.56e-8 Body mass index (change over time); CRC cis rs2242116 0.796 rs9852082 chr3:46972377 T/C cg27129171 chr3:47204927 SETD2 0.62 8.91 0.44 3.53e-17 Birth weight; CRC trans rs4957048 0.577 rs56294732 chr5:568144 T/C cg25482853 chr8:67687455 SGK3 0.99 12.26 0.56 1.03e-28 Ulcerative colitis; CRC cis rs2860975 1.000 rs10159983 chr10:96774437 C/T cg09036531 chr10:96991505 NA -0.42 -5.64 -0.3 3.73e-8 Immune response to smallpox vaccine (IL-6); CRC cis rs6502050 0.799 rs4789673 chr17:80123218 T/C cg13198984 chr17:80129470 CCDC57 0.47 8.35 0.42 1.88e-15 Life satisfaction; CRC cis rs7927771 0.965 rs56400411 chr11:47586376 T/G cg18512352 chr11:47633146 NA -0.48 -9.61 -0.47 1.97e-19 Subjective well-being; CRC cis rs6543140 0.964 rs4851589 chr2:103077145 A/G cg03938978 chr2:103052716 IL18RAP 0.4 6.31 0.33 9.13e-10 Blood protein levels; CRC cis rs972578 0.936 rs4822237 chr22:43364655 G/A cg01576275 chr22:43409880 NA -0.45 -7.29 -0.37 2.37e-12 Mean platelet volume; CRC cis rs3820068 0.734 rs6669156 chr1:15905206 T/A cg27534772 chr1:16042836 PLEKHM2 0.44 7.13 0.37 6.5e-12 Systolic blood pressure; CRC cis rs2032447 0.670 rs198852 chr6:26104448 A/G cg03517284 chr6:25882590 NA 0.43 5.92 0.31 8.25e-9 Intelligence (multi-trait analysis); CRC cis rs28386778 0.863 rs11649912 chr17:61797515 T/A cg22520471 chr17:61851767 DDX42;CCDC47 0.72 11.18 0.52 8.09e-25 Prudent dietary pattern; CRC cis rs7487075 0.619 rs10880968 chr12:46822960 C/T cg22049899 chr12:47219821 SLC38A4 0.31 5.66 0.3 3.29e-8 Itch intensity from mosquito bite; CRC cis rs2153535 0.580 rs9406172 chr6:8515464 T/A cg07606381 chr6:8435919 SLC35B3 0.65 10.53 0.5 1.58e-22 Motion sickness; CRC cis rs2067615 0.524 rs4246257 chr12:107062329 C/T cg15890332 chr12:107067104 RFX4 0.31 5.63 0.3 3.95e-8 Heart rate; CRC cis rs7584330 0.868 rs2325839 chr2:238386286 T/C cg14458575 chr2:238380390 NA 0.66 11.81 0.55 4.4e-27 Prostate cancer; CRC cis rs9486719 0.857 rs11751075 chr6:97065751 G/A cg06623918 chr6:96969491 KIAA0776 -0.8 -10.43 -0.5 3.46e-22 Migraine;Coronary artery disease; CRC cis rs2592394 0.626 rs711828 chr2:177000363 A/G cg13092806 chr2:177043255 NA 0.51 5.79 0.3 1.64e-8 Magnesium levels;Peripheral arterial disease (traffic-related air pollution interaction); CRC trans rs7267979 1.000 rs2258719 chr20:25275843 C/T cg17903999 chr18:56338584 MALT1 -0.43 -6.88 -0.35 3.06e-11 Liver enzyme levels (alkaline phosphatase); CRC cis rs7833790 1.000 rs7460277 chr8:82709777 T/C cg17211192 chr8:82754475 SNX16 -0.56 -6.96 -0.36 1.8e-11 Diastolic blood pressure; CRC cis rs796364 1.000 rs1704186 chr2:200769539 A/C cg12253985 chr2:200820533 C2orf60;C2orf47 0.59 6.53 0.34 2.46e-10 Schizophrenia; CRC trans rs208520 0.690 rs864314 chr6:66814830 G/T cg08225398 chr13:45563328 KIAA1704;NUFIP1 0.63 6.22 0.32 1.54e-9 Exhaled nitric oxide output; CRC cis rs67478160 0.643 rs34813623 chr14:104263294 A/G cg08213375 chr14:104286397 PPP1R13B 0.63 13.36 0.59 8.07e-33 Schizophrenia; CRC cis rs2213920 0.679 rs4978638 chr9:118232778 G/C cg13918206 chr9:118159781 DEC1 0.65 6.17 0.32 1.96e-9 Docetaxel-induced peripheral neuropathy in metastatic castrate-resistant prostate cancer; CRC cis rs11148252 0.634 rs1571189 chr13:52731004 A/T cg02158880 chr13:53174818 NA 0.4 5.69 0.3 2.86e-8 Lewy body disease; CRC cis rs11958404 0.932 rs72816587 chr5:157434144 T/A cg05962755 chr5:157440814 NA 1.01 12.88 0.58 5.12e-31 IgG glycosylation; CRC cis rs17490626 0.568 rs12416520 chr10:71211945 A/G cg12610070 chr10:71211762 TSPAN15 -0.42 -7.57 -0.39 3.77e-13 Thrombosis; CRC cis rs10489202 0.632 rs203779 chr1:167877647 T/G cg24449463 chr1:168025552 DCAF6 -0.6 -8.99 -0.44 2e-17 Schizophrenia; CRC cis rs1448094 0.534 rs974818 chr12:86144307 T/C cg18827107 chr12:86230957 RASSF9 0.39 5.98 0.31 5.88e-9 Major depressive disorder; CRC cis rs6502050 0.835 rs4789751 chr17:80092373 G/T cg02741985 chr17:80059408 CCDC57 0.42 7.01 0.36 1.34e-11 Life satisfaction; CRC cis rs1448094 0.511 rs4492889 chr12:86146735 C/A cg19622623 chr12:86230825 RASSF9 0.4 6.15 0.32 2.22e-9 Major depressive disorder; CRC cis rs7586673 0.930 rs7591506 chr2:161960925 T/G cg16506815 chr2:162101123 NA 0.38 5.62 0.3 4.15e-8 Intelligence (multi-trait analysis); CRC cis rs9534288 0.797 rs9526132 chr13:46609364 A/G cg15192986 chr13:46630673 CPB2 -0.68 -9.89 -0.48 2.31e-20 Blood protein levels; CRC cis rs12024301 0.557 rs12039982 chr1:183614998 G/C cg11505048 chr1:183622726 RGL1;APOBEC4 0.81 7.14 0.37 5.93e-12 Peripheral arterial disease (traffic-related air pollution interaction); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg11064206 chr12:123459532 OGFOD2;ABCB9 0.46 6.47 0.34 3.63e-10 Response to antipsychotic treatment; CRC cis rs728616 0.867 rs61860400 chr10:81723427 T/C cg05935833 chr10:81318306 SFTPA2 -0.76 -8.28 -0.42 3.12e-15 Chronic obstructive pulmonary disease-related biomarkers; CRC trans rs875971 0.660 rs2191268 chr7:66110224 C/T cg27552081 chr17:25621774 WSB1 -0.39 -6.07 -0.32 3.62e-9 Aortic root size; CRC cis rs7762018 0.891 rs7740218 chr6:170141552 G/A cg17545662 chr6:170176663 C6orf70 0.57 6.4 0.33 5.21e-10 Thiazide-induced adverse metabolic effects in hypertensive patients; CRC cis rs1577917 1.000 rs10455449 chr6:86592226 A/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.59 -7.23 -0.37 3.36e-12 Response to antipsychotic treatment; CRC cis rs951366 0.617 rs823074 chr1:205774839 T/C cg23034840 chr1:205782522 SLC41A1 0.57 8.08 0.41 1.22e-14 Menarche (age at onset); CRC cis rs11785400 1.000 rs3824208 chr8:143743653 C/G cg10596483 chr8:143751796 JRK 0.49 6.94 0.36 2.06e-11 Schizophrenia; CRC cis rs7818382 1.000 rs7818382 chr8:96054000 C/T cg09323728 chr8:95962352 TP53INP1 -0.42 -6.72 -0.35 8.17e-11 Alzheimer's disease (late onset); CRC cis rs427394 0.659 rs274675 chr5:6755319 C/T cg15145174 chr5:6755386 POLS -0.42 -6.07 -0.32 3.6e-9 Menopause (age at onset); CRC cis rs6961069 0.777 rs6961024 chr7:80249671 G/T cg04458919 chr7:80252533 CD36 0.35 6.22 0.32 1.53e-9 Platelet count; CRC cis rs6662572 0.737 rs72677530 chr1:46529677 G/A cg03123370 chr1:45965343 CCDC163P;MMACHC 0.49 6.33 0.33 7.85e-10 Blood protein levels; CRC cis rs7312774 0.618 rs12316476 chr12:107343326 C/G cg16260113 chr12:107380972 MTERFD3 0.79 8.09 0.41 1.18e-14 Severe influenza A (H1N1) infection; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg10116431 chr3:143690928 C3orf58 -0.44 -6.67 -0.35 1.08e-10 Myopia (pathological); CRC cis rs2228479 0.717 rs1007932 chr16:89838541 C/T cg19635926 chr16:89946313 TCF25 0.65 6.59 0.34 1.7e-10 Skin colour saturation; CRC cis rs12477438 0.520 rs11123763 chr2:99750673 A/G cg26064155 chr2:99771622 LIPT1;TSGA10 0.88 16.2 0.67 8.61e-44 Chronic sinus infection; CRC cis rs2066819 1.000 rs2066819 chr12:56750204 C/T cg26714650 chr12:56694279 CS -1.4 -10.71 -0.51 3.55e-23 Psoriasis vulgaris; CRC cis rs644799 0.603 rs1255180 chr11:95472134 G/T cg03916912 chr11:95522834 CEP57;FAM76B 0.56 8.67 0.43 2e-16 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs1552244 0.935 rs35148833 chr3:10116937 C/A cg10729496 chr3:10149963 C3orf24 0.55 7.26 0.37 2.73e-12 Alzheimer's disease; CRC cis rs4073416 0.518 rs10148529 chr14:66104703 A/T cg03016385 chr14:66212404 NA -0.45 -6.2 -0.32 1.67e-9 N-glycan levels; CRC cis rs7208859 0.524 rs8069400 chr17:29075967 G/T cg01831904 chr17:28903510 LRRC37B2 -0.6 -5.91 -0.31 8.68e-9 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs7927771 0.770 rs11039203 chr11:47384597 A/G cg18512352 chr11:47633146 NA -0.36 -6.8 -0.35 4.87e-11 Subjective well-being; CRC trans rs1814175 0.645 rs1851857 chr11:49855589 A/C cg15704280 chr7:45808275 SEPT13 -0.94 -16.64 -0.68 1.47e-45 Height; CRC cis rs1862618 0.802 rs7733041 chr5:56107377 A/C cg03609598 chr5:56110824 MAP3K1 -0.73 -9.02 -0.45 1.64e-17 Initial pursuit acceleration; CRC cis rs11583043 0.874 rs72734253 chr1:101380718 A/C cg00063077 chr1:101360652 SLC30A7;EXTL2 0.5 6.72 0.35 7.89e-11 Ulcerative colitis;Inflammatory bowel disease; CRC cis rs4805272 0.626 rs12610050 chr19:29331324 A/T cg12667521 chr19:29218732 NA 0.43 6.33 0.33 8.23e-10 Plasma omega-3 polyunsaturated fatty acid levels (docosahexaenoic acid); CRC cis rs17767392 0.792 rs61991249 chr14:71869546 G/C cg13720639 chr14:72061746 SIPA1L1 -0.48 -6.13 -0.32 2.46e-9 Mitral valve prolapse; CRC cis rs559928 0.557 rs7122408 chr11:63898826 G/T cg19465662 chr11:63993652 NUDT22;TRPT1 0.71 6.6 0.34 1.66e-10 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; CRC trans rs4971059 0.654 rs10157801 chr1:155120012 A/G cg10442358 chr7:100137102 AGFG2 0.38 6.15 0.32 2.28e-9 Breast cancer; CRC trans rs10504229 1.000 rs79561699 chr8:58170601 A/G cg04077850 chr5:125800366 GRAMD3 0.36 6.07 0.32 3.52e-9 Developmental language disorder (linguistic errors); CRC cis rs6570726 0.791 rs9376945 chr6:145828080 T/A cg05347473 chr6:146136440 FBXO30 0.4 6.23 0.32 1.45e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs6840360 1.000 rs10007015 chr4:152603528 C/G cg09659197 chr4:152720779 NA 0.52 10.98 0.52 4.12e-24 Intelligence (multi-trait analysis); CRC cis rs6502050 0.805 rs9915071 chr17:80119138 T/C cg11859384 chr17:80120422 CCDC57 -0.36 -5.75 -0.3 2.06e-8 Life satisfaction; CRC cis rs9527 0.590 rs10786744 chr10:104945028 A/C cg15744005 chr10:104629667 AS3MT 0.32 6.35 0.33 7.15e-10 Arsenic metabolism; CRC cis rs2688608 0.592 rs10824031 chr10:75509273 C/T cg16540259 chr10:75572220 NDST2 0.38 5.74 0.3 2.13e-8 Inflammatory bowel disease; CRC cis rs12143943 0.966 rs2169136 chr1:204564237 G/C cg17419461 chr1:204415978 PIK3C2B 0.39 5.92 0.31 8.17e-9 Cognitive performance; CRC cis rs2070997 0.702 rs7866565 chr9:133766545 C/T cg01000188 chr9:133769184 QRFP 0.58 6.19 0.32 1.75e-9 Response to amphetamines; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg11494149 chr3:20227091 SGOL1 0.44 6.52 0.34 2.67e-10 Intelligence (multi-trait analysis); CRC cis rs2180341 0.960 rs7766802 chr6:127709871 T/G cg24812749 chr6:127587940 RNF146 0.99 13.33 0.59 1.01e-32 Breast cancer; CRC cis rs4363385 0.791 rs512198 chr1:153006245 C/T cg25856811 chr1:152973957 SPRR3 -0.25 -6.76 -0.35 6.38e-11 Inflammatory skin disease; CRC cis rs2949837 0.581 rs2965072 chr7:45980751 G/T cg10677697 chr7:45961126 IGFBP3 0.36 6.39 0.33 5.72e-10 Sitting height ratio; CRC cis rs668210 0.793 rs522553 chr11:65771669 T/C cg02202077 chr11:65769826 EIF1AD;BANF1 0.49 6.45 0.33 4.04e-10 Cerebrospinal fluid biomarker levels; CRC cis rs514406 0.825 rs7523761 chr1:53250915 T/C cg08859206 chr1:53392774 SCP2 0.43 6.91 0.36 2.51e-11 Monocyte count; CRC cis rs9560113 0.573 rs9560134 chr13:112244011 C/T cg10483660 chr13:112241077 NA 0.65 12.3 0.56 7.28e-29 Menarche (age at onset); CRC cis rs4363385 0.747 rs6684188 chr1:152974285 A/G cg25856811 chr1:152973957 SPRR3 -0.25 -6.76 -0.35 6.27e-11 Inflammatory skin disease; CRC trans rs208515 0.525 rs10944869 chr6:66687576 G/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.92 11.64 0.54 1.81e-26 Exhaled nitric oxide levels; CRC cis rs6951245 1.000 rs74785791 chr7:1088494 T/C cg20603222 chr7:1096387 C7orf50;GPR146 -0.73 -8.49 -0.42 7.07e-16 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs4129767 0.869 rs4969142 chr17:76398304 G/A cg02319466 chr17:76381040 PGS1 0.38 5.85 0.31 1.17e-8 HDL cholesterol; CRC cis rs7216064 0.906 rs8074644 chr17:65878217 G/C cg12091567 chr17:66097778 LOC651250 -0.61 -7.68 -0.39 1.84e-13 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CRC trans rs7726839 0.540 rs72705030 chr5:645562 C/T cg25482853 chr8:67687455 SGK3 1.13 13.15 0.59 5.07e-32 Obesity-related traits; CRC cis rs17826219 0.706 rs61643715 chr17:29057762 A/G cg01831904 chr17:28903510 LRRC37B2 -0.62 -6.29 -0.33 9.82e-10 Body mass index; CRC cis rs55702914 0.628 rs11883902 chr2:198341325 A/T cg10820045 chr2:198174542 NA 0.33 5.88 0.31 9.94e-9 Major depression and alcohol dependence; CRC cis rs853679 0.699 rs9468318 chr6:28209531 T/A cg21251018 chr6:28226885 NKAPL 0.51 5.95 0.31 6.9e-9 Depression; CRC trans rs2727020 0.521 rs7131163 chr11:49574774 C/T cg15704280 chr7:45808275 SEPT13 -0.76 -10.06 -0.49 6.26e-21 Coronary artery disease; CRC cis rs7705042 0.865 rs7709361 chr5:141513854 T/C cg08523384 chr5:141488047 NDFIP1 -0.31 -5.68 -0.3 3.02e-8 Asthma; CRC cis rs56283067 0.773 rs56115627 chr6:44683049 G/A cg18551225 chr6:44695536 NA -0.4 -5.68 -0.3 3e-8 Total body bone mineral density; CRC cis rs34375054 0.525 rs7133864 chr12:125606180 C/T cg05341575 chr12:125625032 AACS -0.35 -5.77 -0.3 1.85e-8 Post bronchodilator FEV1/FVC ratio; CRC cis rs2549003 1.000 rs2549005 chr5:131827191 C/T cg00255919 chr5:131827918 IRF1 0.57 11.25 0.53 4.58e-25 Asthma (sex interaction); CRC cis rs35110281 0.748 rs9981460 chr21:45030965 T/A cg04455712 chr21:45112962 RRP1B 0.41 8.02 0.4 1.91e-14 Mean corpuscular volume; CRC cis rs853679 0.517 rs9368550 chr6:28051803 T/A cg23161317 chr6:28129485 ZNF389 0.51 6.36 0.33 6.66e-10 Depression; CRC cis rs921968 0.545 rs2433738 chr2:219551036 T/A cg02176678 chr2:219576539 TTLL4 -0.46 -7.28 -0.37 2.48e-12 Mean corpuscular hemoglobin concentration; CRC cis rs7618501 0.538 rs9856572 chr3:50109073 A/T cg24308560 chr3:49941425 MST1R 0.5 8.26 0.41 3.56e-15 Intelligence (multi-trait analysis); CRC cis rs1129187 0.755 rs13215983 chr6:42924193 C/T cg10862848 chr6:42927986 GNMT -0.38 -9.07 -0.45 1.1e-17 Alzheimer's disease in APOE e4+ carriers; CRC cis rs6952808 0.723 rs57216949 chr7:2030287 G/T cg21782813 chr7:2030301 MAD1L1 0.55 9.45 0.46 6.49e-19 Bipolar disorder and schizophrenia; CRC cis rs6586163 0.967 rs10887877 chr10:90753038 A/G cg03111039 chr10:90751583 FAS;ACTA2 -0.51 -7.47 -0.38 7.23e-13 Chronic lymphocytic leukemia; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg22154562 chr7:100136517 AGFG2 0.44 7.14 0.37 6.16e-12 Liver disease severity in Alagille syndrome; CRC cis rs9916302 0.706 rs11078894 chr17:37396805 C/G cg07936489 chr17:37558343 FBXL20 -0.9 -11.3 -0.53 3.04e-25 Glomerular filtration rate (creatinine); CRC cis rs12760731 0.668 rs12727134 chr1:178266794 T/C cg00404053 chr1:178313656 RASAL2 0.68 8.74 0.43 1.25e-16 Obesity-related traits; CRC cis rs11190604 1.000 rs2495741 chr10:102331795 A/G cg07080220 chr10:102295463 HIF1AN 0.47 6.05 0.32 4.01e-9 Palmitoleic acid (16:1n-7) levels; CRC cis rs6952808 0.717 rs12534679 chr7:1926745 G/A cg21782813 chr7:2030301 MAD1L1 0.37 6.8 0.35 4.8e-11 Bipolar disorder and schizophrenia; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg01928910 chr1:31194314 MATN1 -0.4 -6.59 -0.34 1.8e-10 Liver disease severity in Alagille syndrome; CRC cis rs1580019 0.961 rs11765387 chr7:32494790 T/C cg07520158 chr7:32535189 LSM5;AVL9 0.45 6.48 0.34 3.4e-10 Cognitive ability; CRC cis rs7666738 0.791 rs7665273 chr4:98997413 C/A cg17366294 chr4:99064904 C4orf37 0.44 7.42 0.38 9.81e-13 Colonoscopy-negative controls vs population controls; CRC trans rs916888 0.687 rs199456 chr17:44797919 C/T cg07870213 chr5:140052090 DND1 1.01 11.33 0.53 2.4e-25 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs11958404 0.932 rs6859826 chr5:157429710 T/C cg05962755 chr5:157440814 NA 1.01 12.88 0.58 5.12e-31 IgG glycosylation; CRC cis rs25422 0.938 rs7356858 chr6:118765814 G/C cg01339444 chr6:118972232 C6orf204 0.52 5.9 0.31 8.98e-9 Renal cell carcinoma; CRC cis rs1691799 0.528 rs1472314 chr12:66788838 C/G cg16791601 chr12:66731901 HELB -0.49 -7.67 -0.39 1.95e-13 White blood cell count (basophil); CRC cis rs7586879 0.828 rs9631062 chr2:25110084 C/T cg04586622 chr2:25135609 ADCY3 -0.58 -9.86 -0.48 3.02e-20 Body mass index; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg14094333 chr4:38666051 KLF3;FLJ13197 0.43 6.76 0.35 6.48e-11 Liver disease severity in Alagille syndrome; CRC cis rs10791097 0.667 rs4937584 chr11:130741761 A/G cg12179176 chr11:130786555 SNX19 0.75 12.66 0.57 3.28e-30 Autism spectrum disorder or schizophrenia;Schizophrenia; CRC cis rs1570989 0.841 rs956598 chr6:12027635 A/G cg17804551 chr6:12015979 HIVEP1 0.38 5.71 0.3 2.58e-8 Alcohol and nicotine co-dependence; CRC cis rs7615952 0.641 rs4422257 chr3:125774363 A/G cg18479299 chr3:125709523 NA -0.55 -6.58 -0.34 1.86e-10 Blood pressure (smoking interaction); CRC cis rs6951245 1.000 rs76833820 chr7:1070278 A/T cg03188948 chr7:1209495 NA 0.63 6.52 0.34 2.64e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs4713118 0.587 rs61471148 chr6:28037032 T/A cg12963246 chr6:28129442 ZNF389 0.47 5.64 0.3 3.64e-8 Parkinson's disease; CRC cis rs887829 0.694 rs869283 chr2:234626287 G/A cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.51 -7.98 -0.4 2.38e-14 Metabolic traits;Bilirubin levels;Cholelithiasis-related traits in sickle cell anemia;Metabolite levels;Total bilirubin levels in HIV-1 infection;Serum metabolite levels;Blood metabolite levels; CRC cis rs11758351 1.000 rs2143347 chr6:26198494 C/T cg22723502 chr6:26240528 HIST1H4F -0.39 -5.9 -0.31 9.27e-9 Gout;Renal underexcretion gout; CRC cis rs7927592 0.871 rs12941 chr11:68382193 C/T cg16797656 chr11:68205561 LRP5 0.36 5.69 0.3 2.81e-8 Total body bone mineral density; CRC trans rs7474896 0.778 rs11011310 chr10:37941911 C/T cg16724811 chr16:15130678 PDXDC1 -0.62 -6.01 -0.31 4.96e-9 Obesity (extreme); CRC cis rs6502050 0.835 rs35857672 chr17:80078303 G/A cg13198984 chr17:80129470 CCDC57 -0.46 -7.99 -0.4 2.25e-14 Life satisfaction; CRC cis rs6714710 0.603 rs12995673 chr2:98409046 G/A cg26665480 chr2:98280029 ACTR1B 0.54 7.22 0.37 3.54e-12 Posterior cortical atrophy and Alzheimer's disease; CRC cis rs4727027 0.901 rs34201592 chr7:148842403 C/G cg12479418 chr7:148823350 ZNF425;ZNF398 0.42 5.75 0.3 2.05e-8 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC cis rs860295 0.702 rs10796946 chr1:155429490 A/T cg02153340 chr1:155202674 NA -0.58 -6.88 -0.35 3.08e-11 Body mass index; CRC cis rs3018066 0.748 rs62321365 chr4:107013723 C/T cg01869342 chr4:106983673 TBCK 0.44 6.4 0.33 5.49e-10 Cancer; CRC cis rs10504229 1.000 rs115548028 chr8:58170672 T/C cg05313129 chr8:58192883 C8orf71 -0.47 -6.99 -0.36 1.49e-11 Developmental language disorder (linguistic errors); CRC cis rs796364 1.000 rs281762 chr2:200799201 C/G cg25936922 chr2:200820526 C2orf60;C2orf47 0.7 7.64 0.39 2.33e-13 Schizophrenia; CRC cis rs7223966 0.921 rs11655493 chr17:61733052 C/T cg05941027 chr17:61774174 LIMD2 0.36 6.63 0.34 1.41e-10 Hip circumference adjusted for BMI;Body mass index; CRC cis rs9937943 0.667 rs9938426 chr16:74523739 C/G cg01733217 chr16:74700730 RFWD3 -0.69 -7.41 -0.38 1.07e-12 Neutrophil percentage of white cells; CRC cis rs10479542 0.896 rs4701130 chr5:178982416 C/T cg21226059 chr5:178986404 RUFY1 -0.4 -7.37 -0.38 1.38e-12 Lung cancer; CRC trans rs61931739 0.500 rs11053223 chr12:34481947 T/A cg26384229 chr12:38710491 ALG10B 0.67 8.78 0.44 9.23e-17 Morning vs. evening chronotype; CRC cis rs524281 0.773 rs10791863 chr11:66027358 C/T cg16950941 chr11:66035639 RAB1B -0.72 -8.1 -0.41 1.09e-14 Electroencephalogram traits; CRC cis rs12188164 0.686 rs72711369 chr5:420517 C/T cg16322479 chr5:444228 EXOC3;C5orf55 0.42 6.55 0.34 2.2e-10 Cystic fibrosis severity; CRC cis rs863345 0.608 rs11265013 chr1:158499625 G/A cg12129480 chr1:158549410 OR10X1 -0.3 -6.18 -0.32 1.88e-9 Pneumococcal bacteremia; CRC cis rs10464366 0.571 rs13233049 chr7:39187536 C/T cg18850127 chr7:39170497 POU6F2 0.57 7.56 0.38 4e-13 IgG glycosylation; CRC cis rs17023223 0.537 rs12085616 chr1:119689148 A/C cg05756136 chr1:119680316 WARS2 -0.53 -7.3 -0.37 2.17e-12 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for BMI in active individuals; CRC trans rs931812 0.895 rs4236763 chr8:101913022 G/A cg20993868 chr7:22813445 NA 0.49 8.97 0.44 2.24e-17 Attention deficit hyperactivity disorder and conduct disorder; CRC trans rs2303319 0.504 rs12470743 chr2:162611202 G/A cg23919916 chr10:103825097 HPS6 -0.69 -6.01 -0.31 4.8e-9 Cognitive function; CRC cis rs9325144 0.505 rs7955162 chr12:38711658 G/A cg26384229 chr12:38710491 ALG10B 0.65 9.56 0.47 2.77e-19 Morning vs. evening chronotype; CRC trans rs3780486 0.522 rs7029897 chr9:33124042 T/C cg04842962 chr6:43655489 MRPS18A 0.96 17.45 0.69 9.71e-49 IgG glycosylation; CRC trans rs1864585 0.520 rs17720365 chr8:10679499 C/G cg26278703 chr11:58910052 FAM111A -0.5 -6.07 -0.32 3.43e-9 Neutrophil percentage of white cells;Lymphocyte percentage of white cells; CRC cis rs9611565 0.512 rs6519289 chr22:42170432 A/C cg17554472 chr22:41940697 POLR3H 0.56 5.64 0.3 3.71e-8 Vitiligo; CRC cis rs9322193 0.923 rs4455682 chr6:150021297 C/T cg05861140 chr6:150128134 PCMT1 -0.37 -5.96 -0.31 6.32e-9 Lung cancer; CRC cis rs7666738 0.830 rs1534319 chr4:98964804 T/C cg17366294 chr4:99064904 C4orf37 0.43 7.36 0.38 1.49e-12 Colonoscopy-negative controls vs population controls; CRC cis rs4555082 0.872 rs7153832 chr14:105730563 G/T cg13114125 chr14:105738426 BRF1 -0.75 -11.26 -0.53 4.13e-25 Mean platelet volume;Platelet distribution width; CRC cis rs7487075 0.578 rs12319162 chr12:46837914 T/C cg22049899 chr12:47219821 SLC38A4 0.31 5.78 0.3 1.74e-8 Itch intensity from mosquito bite; CRC cis rs909002 0.849 rs6664789 chr1:32072406 C/G cg13919466 chr1:32135498 COL16A1 -0.32 -5.99 -0.31 5.37e-9 Intelligence (multi-trait analysis); CRC cis rs4713118 0.955 rs9380010 chr6:27683572 A/G cg15786705 chr6:28176104 NA 0.48 6.42 0.33 4.89e-10 Parkinson's disease; CRC cis rs12142240 0.698 rs67487250 chr1:46811333 T/C cg14993813 chr1:46806288 NSUN4 -0.51 -6.48 -0.34 3.28e-10 Menopause (age at onset); CRC cis rs7613875 0.641 rs2624845 chr3:50062437 C/A cg05623727 chr3:50126028 RBM5 -0.58 -10.13 -0.49 3.58e-21 Body mass index; CRC cis rs7264396 0.635 rs6060681 chr20:34506147 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.62 -10.32 -0.49 8.14e-22 Total cholesterol levels; CRC cis rs910316 1.000 rs2300601 chr14:75639571 A/G cg08847533 chr14:75593920 NEK9 0.98 18.48 0.71 8.2e-53 Height; CRC cis rs4722166 0.508 rs1474348 chr7:22767908 C/G cg26061582 chr7:22766209 IL6 0.53 8.12 0.41 9.29e-15 Lung cancer; CRC cis rs6964587 1.000 rs1063243 chr7:91726927 A/C cg17063962 chr7:91808500 NA 0.78 13.63 0.6 7.71e-34 Breast cancer; CRC cis rs35306767 0.807 rs11253513 chr10:968450 C/T cg26597838 chr10:835615 NA 0.8 10.22 0.49 1.81e-21 Eosinophil percentage of granulocytes; CRC cis rs2274273 1.000 rs1009977 chr14:55603002 T/G cg23234261 chr14:55582407 NA -0.28 -5.71 -0.3 2.48e-8 Protein biomarker; CRC cis rs172166 0.516 rs1225710 chr6:28100640 C/T cg02683197 chr6:28174875 NA -0.49 -6.92 -0.36 2.32e-11 Cardiac Troponin-T levels; CRC cis rs7202877 0.706 rs247443 chr16:75465073 G/C cg03315344 chr16:75512273 CHST6 -0.5 -5.75 -0.3 2.04e-8 Type 2 diabetes;Type 1 diabetes; CRC cis rs9807989 0.801 rs10173193 chr2:102975050 G/A cg03938978 chr2:103052716 IL18RAP 0.37 6.07 0.32 3.47e-9 Asthma; CRC cis rs524281 0.861 rs1862005 chr11:65863402 T/C cg14036092 chr11:66035641 RAB1B -0.47 -5.7 -0.3 2.6e-8 Electroencephalogram traits; CRC cis rs8060686 0.565 rs75286242 chr16:68145798 C/T cg08314208 chr16:67682810 RLTPR -0.64 -6.74 -0.35 7.13e-11 HDL cholesterol;Metabolic syndrome; CRC cis rs6998277 1.000 rs16869658 chr8:103633762 C/T cg10187029 chr8:103597600 NA 0.86 11.75 0.54 7.72e-27 Migraine; CRC cis rs10504229 0.775 rs17804840 chr8:58157045 C/T cg08219700 chr8:58056026 NA 0.46 5.72 0.3 2.37e-8 Developmental language disorder (linguistic errors); CRC cis rs9549260 0.755 rs55920113 chr13:41222112 C/T cg21288729 chr13:41239152 FOXO1 0.49 7.68 0.39 1.89e-13 Red blood cell count; CRC cis rs9291683 0.609 rs34709913 chr4:10028955 T/C cg11266682 chr4:10021025 SLC2A9 0.54 11.41 0.53 1.28e-25 Bone mineral density; CRC cis rs10883723 0.810 rs6584504 chr10:104253507 T/C cg11453585 chr10:104263688 ACTR1A;SUFU 0.92 17.58 0.7 2.89e-49 Allergic disease (asthma, hay fever or eczema); CRC cis rs4363385 0.588 rs7540609 chr1:153024589 C/A cg25856811 chr1:152973957 SPRR3 -0.24 -6.54 -0.34 2.38e-10 Inflammatory skin disease; CRC cis rs2066819 1.000 rs1802236 chr12:56679751 A/G cg26714650 chr12:56694279 CS -1.41 -11.64 -0.54 1.88e-26 Psoriasis vulgaris; CRC cis rs12142240 0.698 rs66911505 chr1:46823298 A/G cg00530320 chr1:46809349 NSUN4 0.59 8.03 0.41 1.69e-14 Menopause (age at onset); CRC cis rs2836974 0.666 rs12626405 chr21:40663121 G/T cg22974920 chr21:40686053 BRWD1 -0.43 -5.99 -0.31 5.4e-9 Cognitive function; CRC cis rs1218582 0.651 rs4845396 chr1:154828409 A/G cg24250549 chr1:154909240 PMVK -0.4 -5.91 -0.31 8.77e-9 Prostate cancer; CRC cis rs2404602 0.735 rs2048856 chr15:76800083 C/T cg03037974 chr15:76606532 NA -0.4 -5.91 -0.31 8.43e-9 Blood metabolite levels; CRC trans rs4785204 1.000 rs8064089 chr16:50094482 A/G cg07960154 chr17:37760198 NEUROD2 -0.65 -6.08 -0.32 3.38e-9 Esophageal cancer (squamous cell); CRC cis rs6504622 0.557 rs1867237 chr17:45003829 A/G cg16759221 chr17:45003025 GOSR2 -0.63 -10.24 -0.49 1.56e-21 Orofacial clefts; CRC cis rs12142240 0.698 rs17357676 chr1:46812444 A/G cg00530320 chr1:46809349 NSUN4 0.58 7.8 0.4 8.18e-14 Menopause (age at onset); CRC cis rs6541297 0.878 rs4846905 chr1:230279582 C/T cg05784532 chr1:230284198 GALNT2 -0.46 -6.05 -0.32 3.87e-9 Coronary artery disease; CRC cis rs6693567 0.565 rs35784258 chr1:150405882 T/C cg15654264 chr1:150340011 RPRD2 0.43 6.39 0.33 5.75e-10 Migraine; CRC cis rs7615952 0.641 rs6438951 chr3:125696999 A/G cg15145296 chr3:125709740 NA -0.56 -6.71 -0.35 8.75e-11 Blood pressure (smoking interaction); CRC trans rs8073060 0.586 rs6505487 chr17:33996850 A/G cg19694781 chr19:47549865 TMEM160 -1.05 -14.82 -0.63 2.1e-38 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; CRC cis rs1046896 0.739 rs2379358 chr17:80741612 G/A cg03160526 chr17:80928410 B3GNTL1 0.51 6.94 0.36 2.14e-11 Glycated hemoglobin levels; CRC cis rs8060686 0.920 rs58588228 chr16:67802010 C/T cg08314208 chr16:67682810 RLTPR -0.65 -7.04 -0.36 1.12e-11 HDL cholesterol;Metabolic syndrome; CRC cis rs7949030 0.620 rs2428551 chr11:62329758 T/A cg11742103 chr11:62369870 EML3;MTA2 0.61 11.93 0.55 1.69e-27 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; CRC cis rs12594515 0.506 rs74199860 chr15:45989190 C/T cg01629716 chr15:45996671 NA 0.41 8.48 0.42 7.63e-16 Waist circumference;Weight; CRC cis rs7833790 1.000 rs28696138 chr8:82770794 G/A cg27398817 chr8:82754497 SNX16 0.57 6.82 0.35 4.48e-11 Diastolic blood pressure; CRC cis rs8062405 0.690 rs4787458 chr16:28531287 A/G cg16576597 chr16:28551801 NUPR1 0.45 5.99 0.31 5.39e-9 Cognitive ability (multi-trait analysis);Cognitive ability; CRC cis rs28386778 0.897 rs7207005 chr17:61860355 A/G cg23090583 chr17:61904693 PSMC5;FTSJ3 1.05 20.29 0.75 6.44e-60 Prudent dietary pattern; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg08695707 chr1:197871847 C1orf53 0.47 6.04 0.32 4.13e-9 Thyroid stimulating hormone; CRC cis rs9303280 0.806 rs12709365 chr17:38027400 A/G cg00129232 chr17:37814104 STARD3 -0.46 -7.24 -0.37 3.1e-12 Self-reported allergy; CRC cis rs11711311 1.000 rs9811200 chr3:113531180 A/T cg15478005 chr3:113465772 ATP6V1A;NAA50 0.42 5.78 0.3 1.73e-8 IgG glycosylation; CRC cis rs4862750 0.914 rs9995391 chr4:187873749 A/T cg27532560 chr4:187881888 NA 0.54 9.67 0.47 1.2e-19 Lobe attachment (rater-scored or self-reported); CRC cis rs4700695 0.764 rs36300 chr5:65348153 C/T cg21114390 chr5:65439923 SFRS12 0.64 7.06 0.36 1.02e-11 Facial morphology (factor 19); CRC cis rs4555082 0.834 rs2735819 chr14:105713449 C/T cg18132624 chr14:105716052 BTBD6;BRF1 -0.52 -8.67 -0.43 1.99e-16 Mean platelet volume;Platelet distribution width; CRC cis rs77106637 1.000 rs11605166 chr11:72669777 T/C cg03713592 chr11:72463424 ARAP1 0.77 7.31 0.37 2.04e-12 Type 2 diabetes; CRC cis rs7224737 1.000 rs11869069 chr17:40287101 C/G cg02228675 chr17:40259724 DHX58 -0.5 -6.96 -0.36 1.88e-11 Fibrinogen levels; CRC trans rs10982213 0.830 rs2274163 chr9:117188714 C/T cg03535439 chr6:42981950 MEA1;KLHDC3 0.41 6.36 0.33 6.88e-10 Interleukin-6 levels; CRC cis rs11098499 0.605 rs6833140 chr4:120266822 G/A cg24375607 chr4:120327624 NA 0.47 7.68 0.39 1.89e-13 Corneal astigmatism; CRC trans rs2797160 1.000 rs6933471 chr6:126017029 T/G cg05039488 chr6:79577232 IRAK1BP1 0.51 7.59 0.39 3.37e-13 Endometrial cancer; CRC cis rs9902453 0.817 rs2617881 chr17:28063275 A/T cg26525008 chr17:28256777 EFCAB5;SSH2 -0.61 -9.73 -0.47 7.84e-20 Coffee consumption (cups per day); CRC cis rs7927592 0.546 rs638076 chr11:68202580 A/G cg16797656 chr11:68205561 LRP5 0.63 11.95 0.55 1.43e-27 Total body bone mineral density; CRC cis rs10992471 0.603 rs10820974 chr9:95211876 T/C cg14631576 chr9:95140430 CENPP -0.31 -5.63 -0.3 3.78e-8 Visceral adipose tissue/subcutaneous adipose tissue ratio; CRC cis rs4664293 0.867 rs3771719 chr2:160630964 C/T cg08347373 chr2:160653686 CD302 0.42 7.09 0.36 8.13e-12 Monocyte percentage of white cells; CRC cis rs4862750 1.000 rs4862751 chr4:187904050 G/A cg07414643 chr4:187882934 NA 0.35 5.87 0.31 1.06e-8 Lobe attachment (rater-scored or self-reported); CRC cis rs7552404 0.691 rs61770550 chr1:76366966 C/T cg03433033 chr1:76189801 ACADM 0.72 8.67 0.43 2.04e-16 Blood metabolite levels;Acylcarnitine levels; CRC cis rs2836974 0.644 rs1882779 chr21:40690938 T/C cg06238570 chr21:40685208 BRWD1 -0.83 -13.03 -0.58 1.4e-31 Cognitive function; CRC trans rs875971 0.660 rs2191268 chr7:66110224 C/T cg08224069 chr6:26365425 BTN3A2 -0.38 -6.08 -0.32 3.32e-9 Aortic root size; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg05470666 chr10:74856828 P4HA1 0.42 6.29 0.33 1e-9 Intelligence (multi-trait analysis); CRC cis rs400736 0.602 rs4601608 chr1:8168808 A/G cg25007680 chr1:8021821 PARK7 -0.51 -6.98 -0.36 1.65e-11 Response to antidepressants and depression; CRC cis rs10870270 0.500 rs9419217 chr10:133758379 A/G cg17892150 chr10:133769511 PPP2R2D -0.55 -8.96 -0.44 2.48e-17 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; CRC cis rs2252790 0.859 rs2640853 chr6:116677818 C/G cg18764771 chr6:116381957 FRK -0.23 -6.28 -0.33 1.07e-9 Fast beta electroencephalogram; CRC cis rs9747201 1.000 rs62078307 chr17:80090053 G/T cg09264619 chr17:80180166 NA 0.51 7.28 0.37 2.5e-12 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs9399135 0.967 rs4637662 chr6:135298158 T/C cg22676075 chr6:135203613 NA 0.43 6.66 0.34 1.14e-10 Red blood cell count; CRC cis rs6456156 0.586 rs12529876 chr6:167461501 G/A cg07741184 chr6:167504864 NA 0.39 6.9 0.36 2.63e-11 Primary biliary cholangitis; CRC cis rs644799 0.931 rs496305 chr11:95567035 C/T cg25622487 chr11:95524042 FAM76B;CEP57 0.77 11.99 0.55 9.91e-28 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg06199907 chr16:71674507 MARVELD3 0.4 5.98 0.31 5.75e-9 Myopia (pathological); CRC cis rs910316 0.763 rs175450 chr14:75590340 G/A cg03030879 chr14:75389066 RPS6KL1 0.41 6.34 0.33 7.51e-10 Height; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg10341310 chr8:66582206 MTFR1 -0.39 -6.38 -0.33 5.91e-10 Liver disease severity in Alagille syndrome; CRC cis rs910316 0.664 rs2098252 chr14:75492732 T/C cg08847533 chr14:75593920 NEK9 0.84 14.65 0.63 9e-38 Height; CRC trans rs61931739 0.500 rs34080094 chr12:34547952 G/A cg26384229 chr12:38710491 ALG10B 0.66 8.65 0.43 2.29e-16 Morning vs. evening chronotype; CRC cis rs7617480 0.549 rs9879978 chr3:48846600 T/G cg07636037 chr3:49044803 WDR6 0.86 10.71 0.51 3.62e-23 Subjective well-being (multi-trait analysis);Menarche (age at onset); CRC cis rs6502050 0.835 rs12051747 chr17:80114814 T/C cg02741985 chr17:80059408 CCDC57 0.42 7.04 0.36 1.13e-11 Life satisfaction; CRC cis rs55788414 0.932 rs12103403 chr16:81185904 C/A cg06400318 chr16:81190750 PKD1L2 -0.59 -6.76 -0.35 6.2e-11 Left ventricular obstructive tract defect (maternal effect); CRC cis rs57221529 0.664 rs72704802 chr5:554211 C/T cg14541582 chr5:601475 NA -0.33 -6.36 -0.33 6.85e-10 Lung disease severity in cystic fibrosis; CRC cis rs7312933 0.558 rs4768402 chr12:42755576 A/G cg11827402 chr12:42719852 PPHLN1;ZCRB1 -0.68 -9.89 -0.48 2.33e-20 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CRC trans rs9650657 0.655 rs10093774 chr8:10703293 C/T cg06636001 chr8:8085503 FLJ10661 0.48 7.32 0.37 1.95e-12 Neuroticism; CRC cis rs9916302 0.808 rs12947281 chr17:37652210 G/T cg07936489 chr17:37558343 FBXL20 -0.82 -12.84 -0.58 7.06e-31 Glomerular filtration rate (creatinine); CRC trans rs941408 0.515 rs759067 chr19:2775668 C/T cg19676328 chr12:49525230 TUBA1B -0.48 -6.09 -0.32 3.08e-9 Total cholesterol levels; CRC cis rs2204008 0.837 rs11514225 chr12:38076270 G/A cg26384229 chr12:38710491 ALG10B 0.7 9.27 0.45 2.58e-18 Bladder cancer; CRC cis rs9457247 0.765 rs9457259 chr6:167444281 C/T cg23791538 chr6:167370224 RNASET2 -0.38 -5.7 -0.3 2.63e-8 Crohn's disease; CRC cis rs8105895 0.935 rs2043316 chr19:22251204 C/T cg02657401 chr19:22469223 NA -0.34 -5.65 -0.3 3.56e-8 Body mass index (change over time); CRC cis rs7487075 0.567 rs7486580 chr12:46828348 C/A cg22049899 chr12:47219821 SLC38A4 0.31 5.69 0.3 2.89e-8 Itch intensity from mosquito bite; CRC cis rs1707322 0.686 rs2991979 chr1:46055858 A/G cg03146154 chr1:46216737 IPP -0.67 -9.46 -0.46 6.23e-19 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs35306767 0.903 rs11253485 chr10:919362 C/T cg20503657 chr10:835505 NA 0.97 12.22 0.56 1.45e-28 Eosinophil percentage of granulocytes; CRC cis rs1215050 0.904 rs260898 chr4:98706492 C/G cg05340658 chr4:99064831 C4orf37 -0.5 -6.83 -0.35 4.22e-11 Waist-to-hip ratio adjusted for body mass index; CRC cis rs9303401 0.659 rs62083525 chr17:56658088 A/G cg02118635 chr17:56770003 RAD51C;TEX14 0.78 9.61 0.47 1.92e-19 Cognitive test performance; CRC cis rs2249694 0.960 rs8192776 chr10:135348187 T/C cg20169779 chr10:135381914 SYCE1 0.56 9.17 0.45 5.46e-18 Obesity-related traits; CRC cis rs8013055 0.796 rs4075105 chr14:106000231 C/T cg25008857 chr14:105974488 NA 0.4 5.63 0.3 3.95e-8 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis); CRC cis rs78456975 1.000 rs10189336 chr2:1558015 G/A cg01028140 chr2:1542097 TPO -0.57 -5.86 -0.31 1.11e-8 Placebo response in major depressive disorder (% change in symptom score); CRC cis rs12477438 0.684 rs6756880 chr2:99676991 A/T cg26064155 chr2:99771622 LIPT1;TSGA10 -0.63 -8.55 -0.43 4.61e-16 Chronic sinus infection; CRC cis rs28386778 0.897 rs4968597 chr17:61805747 G/A cg11494091 chr17:61959527 GH2 0.59 9.88 0.48 2.41e-20 Prudent dietary pattern; CRC cis rs5750830 0.594 rs1010170 chr22:39778327 C/T cg25956985 chr22:39795188 MAP3K7IP1 0.45 5.8 0.3 1.56e-8 Intelligence (multi-trait analysis); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg10475689 chr16:12142335 RUNDC2A -0.37 -6.48 -0.34 3.31e-10 Liver disease severity in Alagille syndrome; CRC cis rs9322193 0.847 rs12234128 chr6:149948689 T/C cg13206674 chr6:150067644 NUP43 0.65 9.75 0.47 6.73e-20 Lung cancer; CRC cis rs4072705 0.646 rs2416933 chr9:127245529 C/T cg13476313 chr9:127244764 NR5A1 -0.3 -5.95 -0.31 6.88e-9 Menarche (age at onset); CRC cis rs7617773 0.780 rs6793239 chr3:48351618 G/T cg11946769 chr3:48343235 NME6 0.73 9.79 0.47 4.96e-20 Coronary artery disease; CRC cis rs8005677 1.000 rs4981446 chr14:23381413 A/G cg01529538 chr14:23388837 RBM23 0.4 6.16 0.32 2.14e-9 Cognitive ability (multi-trait analysis); CRC cis rs7618915 0.571 rs6805539 chr3:52609710 T/A cg07507251 chr3:52567010 NT5DC2 0.43 6.18 0.32 1.88e-9 Bipolar disorder; CRC trans rs875971 0.660 rs2191268 chr7:66110224 C/T cg10546040 chr5:78280163 ARSB -0.41 -6.33 -0.33 8.2e-10 Aortic root size; CRC cis rs9291683 0.561 rs3733584 chr4:10036506 T/C cg11266682 chr4:10021025 SLC2A9 0.53 11.09 0.52 1.78e-24 Bone mineral density; CRC cis rs9457247 0.967 rs382009 chr6:167403121 G/C cg23791538 chr6:167370224 RNASET2 -0.38 -5.93 -0.31 7.48e-9 Crohn's disease; CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg20784733 chr7:66205729 RABGEF1 0.36 6.31 0.33 9.23e-10 Obesity-related traits; CRC cis rs28386778 0.897 rs8081454 chr17:61842646 A/G cg11494091 chr17:61959527 GH2 0.63 10.73 0.51 3.01e-23 Prudent dietary pattern; CRC cis rs780096 0.526 rs2911713 chr2:27640980 G/A cg27432699 chr2:27873401 GPN1 -0.51 -7.77 -0.39 9.87e-14 Total body bone mineral density; CRC cis rs9916302 0.706 rs9906612 chr17:37547631 A/C cg15445000 chr17:37608096 MED1 -0.35 -6.2 -0.32 1.71e-9 Glomerular filtration rate (creatinine); CRC cis rs9911578 0.967 rs9907940 chr17:56663842 A/G cg05425664 chr17:57184151 TRIM37 -0.51 -8.05 -0.41 1.54e-14 Intelligence (multi-trait analysis); CRC cis rs4481887 0.893 rs6681339 chr1:248482761 C/G cg00666640 chr1:248458726 OR2T12 0.46 7.97 0.4 2.59e-14 Common traits (Other); CRC cis rs16867321 0.950 rs16867322 chr2:181369403 A/G cg23363182 chr2:181467187 NA -0.49 -6.09 -0.32 3.16e-9 Obesity; CRC cis rs9527 0.637 rs12219247 chr10:104613361 A/G cg08772003 chr10:104629869 AS3MT -0.41 -6.82 -0.35 4.31e-11 Arsenic metabolism; CRC cis rs6860806 0.661 rs2136188 chr5:131577514 A/G cg04518342 chr5:131593106 PDLIM4 -0.47 -8.79 -0.44 8.33e-17 Breast cancer; CRC cis rs10752881 1.000 rs12133714 chr1:182988252 A/G ch.1.3577855R chr1:183094577 LAMC1 0.86 15.22 0.64 5.91e-40 Colorectal cancer; CRC trans rs11098499 0.954 rs35063680 chr4:120387102 T/C cg25214090 chr10:38739885 LOC399744 0.66 10.55 0.5 1.36e-22 Corneal astigmatism; CRC cis rs7659604 0.702 rs61217486 chr4:122693973 T/C cg19748678 chr4:122722346 EXOSC9 0.7 11.28 0.53 3.68e-25 Type 2 diabetes; CRC cis rs7926971 0.756 rs11826266 chr11:12659535 T/C cg25843174 chr11:12811716 TEAD1 0.35 6.08 0.32 3.28e-9 Height; CRC cis rs10911232 0.507 rs4652763 chr1:182994084 A/G ch.1.3577855R chr1:183094577 LAMC1 0.86 15.15 0.64 1.1e-39 Hypertriglyceridemia; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg27149388 chr12:47473796 AMIGO2 0.39 6.46 0.34 3.76e-10 Liver disease severity in Alagille syndrome; CRC cis rs11628318 0.614 rs8010455 chr14:103164681 A/G cg23071808 chr14:103021642 NA 0.61 6.87 0.35 3.27e-11 Platelet count; CRC cis rs736408 0.677 rs678 chr3:52820981 A/T cg11645453 chr3:52864694 ITIH4 0.38 6.47 0.34 3.51e-10 Bipolar disorder; CRC cis rs2839186 0.771 rs2280957 chr21:47642272 A/G cg05896524 chr21:47604654 C21orf56 -0.46 -6.94 -0.36 2.09e-11 Testicular germ cell tumor; CRC cis rs10256972 0.721 rs2030959 chr7:1075906 T/C cg03923535 chr7:1197113 ZFAND2A 0.52 7.41 0.38 1.1e-12 Longevity;Endometriosis; CRC cis rs9527 0.615 rs10883800 chr10:104671212 A/C cg04362960 chr10:104952993 NT5C2 0.59 8.44 0.42 9.97e-16 Arsenic metabolism; CRC cis rs853679 0.882 rs4713139 chr6:28092685 C/T cg06470822 chr6:28175283 NA 0.81 6.57 0.34 2.03e-10 Depression; CRC cis rs1570884 0.516 rs9316463 chr13:50176844 G/A cg08779649 chr13:50194554 NA 0.45 9.29 0.46 2.21e-18 Sum basophil neutrophil counts;Sum neutrophil eosinophil counts;Neutrophil count;Myeloid white cell count;Granulocyte count; CRC cis rs548181 0.611 rs609200 chr11:125383808 G/A cg03464685 chr11:125439445 EI24 -1.31 -12.31 -0.56 6.49e-29 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs12477438 0.765 rs7591992 chr2:99668954 A/C cg26064155 chr2:99771622 LIPT1;TSGA10 -0.63 -8.55 -0.43 4.61e-16 Chronic sinus infection; CRC cis rs6860806 0.695 rs6867282 chr5:131583120 G/C cg11843238 chr5:131593191 PDLIM4 0.42 7.85 0.4 5.73e-14 Breast cancer; CRC cis rs7615952 0.800 rs13086460 chr3:125646417 C/T cg05084668 chr3:125655381 ALG1L -0.61 -9.21 -0.45 3.96e-18 Blood pressure (smoking interaction); CRC cis rs35110281 0.782 rs2838329 chr21:45023329 T/C cg04455712 chr21:45112962 RRP1B 0.41 7.97 0.4 2.57e-14 Mean corpuscular volume; CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg01402448 chr6:136571605 FAM54A 0.4 6.29 0.33 1.03e-9 Obesity-related traits; CRC cis rs4843747 0.671 rs9933794 chr16:88116981 T/C cg17633681 chr16:88106987 BANP 0.81 14.3 0.62 2.08e-36 Menopause (age at onset); CRC cis rs1223397 0.530 rs2458313 chr6:13309789 C/T cg20827128 chr6:13274284 PHACTR1 0.39 6.03 0.32 4.44e-9 Blood pressure; CRC cis rs10751667 0.621 rs7396107 chr11:970029 C/T cg01483505 chr11:975446 AP2A2 0.46 7.66 0.39 2.11e-13 Alzheimer's disease (late onset); CRC cis rs7089973 0.604 rs11196941 chr10:116596258 A/G cg23260525 chr10:116636907 FAM160B1 0.35 8.06 0.41 1.38e-14 Bipolar disorder or attention deficit hyperactivity disorder; CRC cis rs6062302 0.522 rs3787112 chr20:62222411 G/A cg06363034 chr20:62225388 GMEB2 -0.45 -6.91 -0.36 2.58e-11 Glioblastoma; CRC cis rs6089829 0.962 rs2277769 chr20:61666805 C/T cg03213289 chr20:61660250 NA 0.35 7.37 0.38 1.39e-12 Prostate cancer (SNP x SNP interaction); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg15216925 chr5:179921655 CNOT6 0.5 8.62 0.43 2.83e-16 Liver disease severity in Alagille syndrome; CRC cis rs250677 0.652 rs36045 chr5:148441184 A/G cg23229984 chr5:148520753 ABLIM3 -0.55 -7.25 -0.37 3.09e-12 Breast cancer; CRC cis rs6502050 0.699 rs9901808 chr17:80107814 C/T cg11859384 chr17:80120422 CCDC57 -0.37 -5.8 -0.3 1.57e-8 Life satisfaction; CRC cis rs28386778 0.897 rs6504185 chr17:61848792 A/G cg25654072 chr17:61904446 PSMC5;FTSJ3 0.73 11.3 0.53 2.96e-25 Prudent dietary pattern; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg06232999 chr12:96429744 LTA4H 0.4 6.01 0.31 4.95e-9 Liver disease severity in Alagille syndrome; CRC cis rs7113874 0.569 rs11041999 chr11:8605739 T/C cg02811074 chr11:8615871 STK33 0.35 5.99 0.31 5.36e-9 Body mass index in physically active individuals;Body mass index (joint analysis main effects and physical activity interaction); CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg15392845 chr14:73360933 DPF3 0.47 6.19 0.32 1.75e-9 Thyroid stimulating hormone; CRC cis rs9549367 0.789 rs9549718 chr13:113909822 A/G cg00898013 chr13:113819073 PROZ -0.46 -6.4 -0.33 5.37e-10 Platelet distribution width; CRC trans rs10028773 0.666 rs12498657 chr4:120262866 G/C cg25214090 chr10:38739885 LOC399744 0.54 8.66 0.43 2.11e-16 Educational attainment; CRC trans rs6076960 0.684 rs3852947 chr20:6255341 A/G cg21095983 chr6:86352623 SYNCRIP 0.58 8.58 0.43 3.77e-16 Smooth-surface caries; CRC trans rs2243480 1.000 rs2961102 chr7:65424658 A/G cg10756647 chr7:56101905 PSPH 0.71 7.67 0.39 1.99e-13 Diabetic kidney disease; CRC cis rs10479542 0.784 rs6601050 chr5:178986261 C/G cg22764044 chr5:178986830 RUFY1 -0.4 -6.99 -0.36 1.5e-11 Lung cancer; CRC cis rs9388451 0.903 rs7758115 chr6:126061502 C/T cg10911889 chr6:126070802 HEY2 0.39 6.03 0.32 4.49e-9 Brugada syndrome; CRC cis rs7412746 0.658 rs11582281 chr1:150826831 T/C cg15448220 chr1:150897856 SETDB1 0.56 7.83 0.4 6.85e-14 Melanoma; CRC trans rs4933824 0.826 rs10884099 chr10:83815369 T/C cg09212058 chr2:37543459 PRKD3 -0.67 -6.1 -0.32 2.94e-9 Response to iloperidone treatment (QT prolongation); CRC cis rs13108904 0.875 rs1732099 chr4:1282696 T/C cg02018176 chr4:1364513 KIAA1530 -0.41 -7.01 -0.36 1.38e-11 Obesity-related traits; CRC cis rs12701220 0.857 rs1057558 chr7:1062366 A/G cg26769984 chr7:1090371 C7orf50 0.65 9.14 0.45 6.46e-18 Bronchopulmonary dysplasia; CRC cis rs13256369 0.708 rs11249886 chr8:8562021 T/A cg17143192 chr8:8559678 CLDN23 0.52 6.69 0.35 9.86e-11 Obesity-related traits; CRC cis rs6484504 0.532 rs11031330 chr11:31275073 G/A cg14844989 chr11:31128820 NA -0.34 -6.1 -0.32 2.97e-9 Red blood cell count; CRC cis rs7617773 0.707 rs13061269 chr3:48373343 C/T cg11946769 chr3:48343235 NME6 0.76 10.09 0.49 4.95e-21 Coronary artery disease; CRC cis rs2739330 0.731 rs4822450 chr22:24242887 C/T cg15242686 chr22:24348715 GSTTP1 0.39 5.96 0.31 6.48e-9 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs2404602 0.583 rs12913096 chr15:76551852 C/T cg22467129 chr15:76604101 ETFA -0.46 -7.95 -0.4 2.92e-14 Blood metabolite levels; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg18845289 chr12:121124611 MLEC 0.43 6.4 0.33 5.27e-10 Intelligence (multi-trait analysis); CRC cis rs11030122 0.547 rs4910865 chr11:3950546 T/C cg18678763 chr11:4115507 RRM1 -0.38 -6.52 -0.34 2.58e-10 Mean platelet volume;Platelet distribution width; CRC cis rs6570726 0.967 rs6903252 chr6:145922777 A/G cg05347473 chr6:146136440 FBXO30 0.37 5.66 0.3 3.38e-8 Lobe attachment (rater-scored or self-reported); CRC cis rs16867321 0.639 rs12466770 chr2:181441312 C/G cg23363182 chr2:181467187 NA 0.59 9.05 0.45 1.29e-17 Obesity; CRC cis rs524281 0.861 rs7931544 chr11:65917034 C/T cg14036092 chr11:66035641 RAB1B -0.47 -5.71 -0.3 2.54e-8 Electroencephalogram traits; CRC cis rs317689 0.702 rs544696 chr12:69749939 T/C cg20891283 chr12:69753455 YEATS4 0.71 9.96 0.48 1.37e-20 Response to diuretic therapy; CRC cis rs13108904 0.967 rs1732107 chr4:1276758 G/A cg02018176 chr4:1364513 KIAA1530 -0.48 -8.12 -0.41 9.57e-15 Obesity-related traits; CRC cis rs10022260 1 rs10022260 chr4:83793921 C/T cg00595051 chr4:83955429 COPS4 -0.38 -5.69 -0.3 2.89e-8 Adult asthma; CRC cis rs736408 0.812 rs1076425 chr3:52825462 A/G cg05573699 chr3:52720067 GNL3;PBRM1 -0.46 -5.97 -0.31 6.14e-9 Bipolar disorder; CRC cis rs10779751 1.000 rs2253213 chr1:11265785 A/G cg08854313 chr1:11322531 MTOR 0.62 8.05 0.41 1.55e-14 Body mass index; CRC trans rs208520 0.586 rs208442 chr6:66900618 T/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.66 -9.21 -0.45 3.94e-18 Exhaled nitric oxide output; CRC cis rs7927771 0.725 rs11039265 chr11:47523214 C/A cg05585544 chr11:47624801 NA -0.63 -11.5 -0.54 5.88e-26 Subjective well-being; CRC cis rs3888647 0.622 rs4758618 chr11:2995186 A/T cg05729581 chr11:3078854 CARS -0.51 -7.48 -0.38 6.84e-13 Type 2 diabetes; CRC cis rs10791097 0.967 rs10791099 chr11:130718813 G/C cg12179176 chr11:130786555 SNX19 0.57 8.81 0.44 7.22e-17 Autism spectrum disorder or schizophrenia;Schizophrenia; CRC trans rs9825823 0.617 rs2083264 chr3:61074229 A/G cg04117853 chr4:48832952 OCIAD1 0.43 6.41 0.33 5.08e-10 Depressive symptom measurement or major depressive disorder; CRC cis rs12403795 0.527 rs17648797 chr1:150338002 C/G cg17724175 chr1:150552817 MCL1 0.66 5.87 0.31 1.07e-8 Illicit drug use; CRC cis rs4700695 0.686 rs27075 chr5:65370379 C/T cg21114390 chr5:65439923 SFRS12 -0.63 -7.08 -0.36 8.9e-12 Facial morphology (factor 19); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg08619561 chr20:30311682 BCL2L1 0.38 6.03 0.32 4.5e-9 Intelligence (multi-trait analysis); CRC cis rs7264396 0.790 rs6060530 chr20:34227663 C/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.58 -9.07 -0.45 1.08e-17 Total cholesterol levels; CRC cis rs2836974 0.831 rs34294410 chr21:40555160 C/G cg06238570 chr21:40685208 BRWD1 0.79 10.83 0.51 1.41e-23 Cognitive function; CRC cis rs7647973 1.000 rs3866330 chr3:49582994 T/C cg07690219 chr3:49449608 TCTA;RHOA -0.54 -6.35 -0.33 7.21e-10 Menarche (age at onset); CRC cis rs736408 0.562 rs12497998 chr3:52793602 C/T cg05573699 chr3:52720067 GNL3;PBRM1 -0.46 -6.66 -0.34 1.18e-10 Bipolar disorder; CRC trans rs208520 0.690 rs10455194 chr6:66743356 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 1.05 14.83 0.63 1.81e-38 Exhaled nitric oxide output; CRC trans rs7267979 0.773 rs6132821 chr20:25226192 A/G cg17903999 chr18:56338584 MALT1 -0.41 -6.65 -0.34 1.23e-10 Liver enzyme levels (alkaline phosphatase); CRC cis rs6951245 0.872 rs75398423 chr7:1098414 T/G cg20603222 chr7:1096387 C7orf50;GPR146 -0.72 -8.66 -0.43 2.19e-16 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs863345 0.625 rs6427439 chr1:158460357 C/A cg12129480 chr1:158549410 OR10X1 -0.29 -6.04 -0.32 4.2e-9 Pneumococcal bacteremia; CRC cis rs9814567 0.752 rs4605591 chr3:134328361 C/T cg06109529 chr3:134205091 CEP63;ANAPC13 -0.67 -9.62 -0.47 1.8e-19 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs6500395 1.000 rs12447645 chr16:48694440 A/G cg04672837 chr16:48644449 N4BP1 -0.45 -6.63 -0.34 1.38e-10 Response to tocilizumab in rheumatoid arthritis; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg01807202 chr4:130014778 C4orf33;SCLT1 0.47 6.38 0.33 5.91e-10 Anxiety disorder; CRC cis rs6952808 0.543 rs4719436 chr7:2141239 G/A cg04267008 chr7:1944627 MAD1L1 -0.67 -9.3 -0.46 2.03e-18 Bipolar disorder and schizophrenia; CRC cis rs748404 0.660 rs690512 chr15:43717678 A/G cg15269541 chr15:43626905 ADAL -0.36 -5.64 -0.3 3.7e-8 Lung cancer; CRC cis rs7772486 0.682 rs1337840 chr6:146042558 T/C cg13319975 chr6:146136371 FBXO30 0.4 5.89 0.31 9.62e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs11608355 1.000 rs7969719 chr12:109883577 C/T cg19025524 chr12:109796872 NA -0.48 -7.06 -0.36 9.97e-12 Neuroticism; CRC cis rs2742417 0.603 rs2742398 chr3:45759036 A/G cg04837898 chr3:45731254 SACM1L -0.49 -7.93 -0.4 3.51e-14 Response to anti-depressant treatment in major depressive disorder; CRC trans rs1814175 0.647 rs1404157 chr11:49917301 G/C cg11707556 chr5:10655725 ANKRD33B -0.38 -7.09 -0.36 8.34e-12 Height; CRC trans rs9291683 0.507 rs3775940 chr4:10025163 A/T cg26043149 chr18:55253948 FECH 0.5 7.6 0.39 3.04e-13 Bone mineral density; CRC cis rs12983728 0.732 rs34003091 chr19:58662254 T/C cg21877656 chr19:58662188 ZNF329 0.7 7.66 0.39 2.13e-13 Cholesterol, total; CRC cis rs7932354 0.710 rs10838621 chr11:46851459 C/T cg19486271 chr11:47235900 DDB2 -0.47 -7.72 -0.39 1.36e-13 Bone mineral density (hip);Bone mineral density; CRC cis rs9467711 0.559 rs9393727 chr6:26500011 C/G cg16898833 chr6:26189333 HIST1H4D 0.8 7.01 0.36 1.33e-11 Autism spectrum disorder or schizophrenia; CRC cis rs728616 0.558 rs61859215 chr10:82151148 G/A cg05935833 chr10:81318306 SFTPA2 -0.58 -6.97 -0.36 1.74e-11 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs8014204 0.762 rs12889665 chr14:75234830 T/G cg03030879 chr14:75389066 RPS6KL1 -0.41 -6.47 -0.34 3.5e-10 Caffeine consumption; CRC cis rs11958404 0.932 rs6870420 chr5:157437166 T/C cg05962755 chr5:157440814 NA 1.01 12.88 0.58 5.12e-31 IgG glycosylation; CRC trans rs2727020 0.576 rs12293522 chr11:49558425 T/A cg03929089 chr4:120376271 NA -0.91 -17.1 -0.69 2.35e-47 Coronary artery disease; CRC cis rs6456156 0.586 rs12198816 chr6:167483546 G/A cg23791538 chr6:167370224 RNASET2 -0.39 -5.79 -0.3 1.62e-8 Primary biliary cholangitis; CRC cis rs3736485 0.934 rs8038203 chr15:51870683 G/A cg08986416 chr15:51914746 DMXL2 -0.46 -6.63 -0.34 1.41e-10 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs6952808 0.723 rs55689856 chr7:2037215 G/A cg00106254 chr7:1943704 MAD1L1 -0.54 -7.98 -0.4 2.41e-14 Bipolar disorder and schizophrenia; CRC trans rs7615952 0.611 rs35321002 chr3:125612065 G/C cg07211511 chr3:129823064 LOC729375 -1.01 -12.7 -0.57 2.45e-30 Blood pressure (smoking interaction); CRC cis rs6496667 0.779 rs28651333 chr15:91021718 C/T cg04176472 chr15:90893244 GABARAPL3 0.51 7.33 0.37 1.77e-12 Rheumatoid arthritis; CRC cis rs9389248 0.737 rs12664956 chr6:135384188 T/C cg22676075 chr6:135203613 NA 0.6 8.85 0.44 5.56e-17 High light scatter reticulocyte percentage of red cells; CRC cis rs736408 0.774 rs4687551 chr3:52823448 C/T cg11645453 chr3:52864694 ITIH4 -0.39 -6.56 -0.34 2.15e-10 Bipolar disorder; CRC cis rs4594175 0.926 rs11157804 chr14:51630340 A/G cg23942311 chr14:51606299 NA -0.59 -9.31 -0.46 1.83e-18 Cancer; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg01225317 chr1:205473878 CDK18 0.47 6.97 0.36 1.76e-11 Intelligence (multi-trait analysis); CRC cis rs941873 0.772 rs1316312 chr10:81110417 G/C cg09469691 chr10:81107165 PPIF 0.53 8.36 0.42 1.76e-15 Height; CRC cis rs780094 0.544 rs2303370 chr2:27651375 C/T cg12648201 chr2:27665141 KRTCAP3 -0.28 -5.62 -0.3 4.05e-8 Calcium levels;Fasting blood insulin;Metabolic traits;Triglyceride levels;Fasting plasma glucose;Urate levels in overweight individuals;Urate levels in obese individuals;Uric acid levels;Height;Age-related diseases, mortality and associated endophenotypes;Renal underexcretion gout;Fasting blood glucose (BMI interaction);Urate levels;Gondoic acid (20:1n-9) levels;Fasting blood insulin (BMI interaction);Triglycerides;Plasma omega-3 polyunsaturated fatty acid levels (docosapentaenoic acid);Type 2 diabetes;Nonalcoholic fatty liver disease;Hypertriglyceridemia;C-reactive protein;Age-related disease endophenotypes;LDL cholesterol;Metabolic syndrome;Crohn's disease;Alcohol consumption (drinks per week);Homeostasis model assessment of insulin resistance;Alcohol consumption;Red blood cell count;Fasting blood glucose; CRC trans rs11039798 0.698 rs76315297 chr11:48240475 T/C cg27395922 chr11:50257633 LOC441601 0.49 6.2 0.32 1.71e-9 Axial length; CRC cis rs7927592 0.956 rs948315 chr11:68309140 T/C cg01657329 chr11:68192670 LRP5 -0.49 -7.12 -0.37 6.76e-12 Total body bone mineral density; CRC cis rs924607 0.900 rs1697950 chr5:616890 G/A cg04221910 chr5:616842 CEP72 -0.41 -6.89 -0.36 2.85e-11 Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia; CRC trans rs11039798 0.582 rs1483119 chr11:48382334 A/G cg03929089 chr4:120376271 NA -0.64 -6.85 -0.35 3.56e-11 Axial length; CRC cis rs7659604 1.000 rs7660078 chr4:122665577 G/T cg20573242 chr4:122745356 CCNA2 0.43 6.47 0.34 3.46e-10 Type 2 diabetes; CRC trans rs6550704 0.687 rs9865314 chr3:22634337 A/G cg20623943 chr1:47799834 CMPK1 -0.42 -6.25 -0.33 1.24e-9 Daytime sleep phenotypes; CRC cis rs1552244 1.000 rs113522867 chr3:10154503 T/C cg16606324 chr3:10149918 C3orf24 0.72 9.48 0.46 5.05e-19 Alzheimer's disease; CRC cis rs13108904 0.870 rs4974577 chr4:1266046 G/A cg16405210 chr4:1374714 KIAA1530 -0.43 -5.82 -0.31 1.43e-8 Obesity-related traits; CRC cis rs7705042 0.865 rs7709361 chr5:141513854 T/C cg07392085 chr5:141489673 NDFIP1 0.45 7.26 0.37 2.75e-12 Asthma; CRC cis rs7937682 0.883 rs490492 chr11:111465150 C/T cg19812747 chr11:111475976 SIK2 -0.57 -9.72 -0.47 8.51e-20 Primary sclerosing cholangitis; CRC cis rs7937682 0.883 rs568506 chr11:111466429 C/T cg09085632 chr11:111637200 PPP2R1B -0.94 -17.74 -0.7 7.01e-50 Primary sclerosing cholangitis; CRC cis rs59918340 0.764 rs2304282 chr8:142229543 A/G cg23750338 chr8:142222470 SLC45A4 0.62 11.56 0.54 3.48e-26 Immature fraction of reticulocytes; CRC cis rs9660992 0.649 rs72745216 chr1:205261016 G/A cg21643547 chr1:205240462 TMCC2 -0.44 -7.06 -0.36 1.01e-11 Mean corpuscular volume;Mean platelet volume; CRC cis rs11190604 0.767 rs10883491 chr10:102196071 G/T cg07080220 chr10:102295463 HIF1AN 0.48 5.91 0.31 8.64e-9 Palmitoleic acid (16:1n-7) levels; CRC cis rs10504229 1.000 rs78953746 chr8:58170608 A/G cg24829409 chr8:58192753 C8orf71 -0.68 -11.36 -0.53 1.89e-25 Developmental language disorder (linguistic errors); CRC cis rs9341808 0.754 rs9352817 chr6:81025879 T/G cg08355045 chr6:80787529 NA 0.38 6.28 0.33 1.07e-9 Sitting height ratio; CRC cis rs12630931 0.929 rs34652817 chr3:31983470 G/A cg21375017 chr3:31988082 OSBPL10 0.44 5.96 0.31 6.63e-9 Periodontal disease-related phenotypes; CRC trans rs7937682 0.855 rs539553 chr11:111477333 C/T cg18187862 chr3:45730750 SACM1L 0.46 6.62 0.34 1.49e-10 Primary sclerosing cholangitis; CRC cis rs9311474 0.539 rs12489828 chr3:52567014 G/T cg15147215 chr3:52552868 STAB1 -0.73 -14.49 -0.62 3.98e-37 Electroencephalogram traits; CRC cis rs4680 1.000 rs4633 chr22:19950235 C/T cg23601416 chr22:19950040 COMT 0.29 7.79 0.39 8.98e-14 Blood metabolite levels; CRC cis rs875971 0.862 rs12537823 chr7:65720884 C/T cg12463550 chr7:65579703 CRCP 0.52 7.38 0.38 1.33e-12 Aortic root size; CRC cis rs9486719 0.901 rs13206547 chr6:97006942 T/C cg18709589 chr6:96969512 KIAA0776 -0.52 -5.85 -0.31 1.21e-8 Migraine;Coronary artery disease; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg07851057 chr5:70751686 BDP1 0.39 6.24 0.33 1.38e-9 Liver disease severity in Alagille syndrome; CRC cis rs1580019 0.587 rs1597555 chr7:32546118 T/G cg14728415 chr7:32535168 LSM5;AVL9 0.45 6.48 0.34 3.28e-10 Cognitive ability; CRC cis rs877282 0.898 rs12358966 chr10:758703 A/G cg06581033 chr10:766294 NA -0.5 -5.82 -0.31 1.4e-8 Uric acid levels; CRC cis rs62064224 0.589 rs9889607 chr17:30785585 A/C cg21839984 chr17:30846986 MYO1D 0.33 5.76 0.3 1.93e-8 Schizophrenia; CRC trans rs948562 1.000 rs11229535 chr11:58348386 A/G cg26660744 chr1:1573181 CDK11B 0.53 6.19 0.32 1.83e-9 Lymphoma; CRC cis rs62064224 0.714 rs8074594 chr17:30632998 G/A cg09324608 chr17:30823087 MYO1D 0.36 6.27 0.33 1.14e-9 Schizophrenia; CRC cis rs7707921 1.000 rs749401 chr5:81561369 T/C cg17942617 chr5:81327376 ATG10 0.39 5.8 0.3 1.53e-8 Breast cancer; CRC cis rs875971 0.619 rs2302918 chr7:66000932 A/G cg18876405 chr7:65276391 NA 0.6 10.74 0.51 2.99e-23 Aortic root size; CRC cis rs7542091 0.704 rs9429825 chr1:210052133 C/G cg21951975 chr1:209979733 IRF6 0.35 5.9 0.31 8.8e-9 Monobrow; CRC cis rs4481887 1.000 rs7525344 chr1:248467565 C/T cg13385794 chr1:248469461 NA -0.33 -5.7 -0.3 2.73e-8 Common traits (Other); CRC cis rs68170813 0.559 rs4730229 chr7:106925353 A/G cg02696742 chr7:106810147 HBP1 -0.61 -6.71 -0.35 8.63e-11 Coronary artery disease; CRC cis rs10256972 0.591 rs6968988 chr7:1169619 A/G cg23978390 chr7:1156363 C7orf50 0.54 7.76 0.39 1.11e-13 Longevity;Endometriosis; CRC cis rs798554 0.797 rs798487 chr7:2802943 G/A cg13628971 chr7:2884303 GNA12 0.54 7.24 0.37 3.15e-12 Height; CRC trans rs703108 0.731 rs7898954 chr10:22323646 A/G cg12214090 chr6:127741813 NA -0.51 -6.06 -0.32 3.68e-9 Monocyte percentage of white cells; CRC cis rs919433 0.783 rs2565165 chr2:198233575 T/G cg10820045 chr2:198174542 NA 0.45 7.89 0.4 4.58e-14 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC cis rs2204008 0.748 rs11514352 chr12:38246954 C/T cg26384229 chr12:38710491 ALG10B 0.69 9.23 0.45 3.37e-18 Bladder cancer; CRC cis rs1728785 1.000 rs698719 chr16:68560125 C/T cg02972257 chr16:68554789 NA -0.59 -7.34 -0.38 1.71e-12 Ulcerative colitis; CRC cis rs4737010 0.570 rs2111804 chr8:41644266 A/T cg17182837 chr8:41585554 ANK1 -0.54 -7.61 -0.39 2.99e-13 Lymphocyte counts;High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Reticulocyte count;Reticulocyte fraction of red cells;Mean corpuscular volume;Immature fraction of reticulocytes;Mean corpuscular hemoglobin concentration; CRC cis rs17767294 0.612 rs12332927 chr6:27955115 T/C cg25164649 chr6:28176230 NA 0.57 6.14 0.32 2.32e-9 Parkinson's disease; CRC cis rs9534288 0.830 rs3783202 chr13:46631869 G/A cg15192986 chr13:46630673 CPB2 -0.78 -10.96 -0.52 5.02e-24 Blood protein levels; CRC cis rs6582630 0.555 rs8189479 chr12:38308240 C/T cg26384229 chr12:38710491 ALG10B -0.53 -7.69 -0.39 1.74e-13 Drug-induced liver injury (flucloxacillin); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg24884940 chr4:84406509 FAM175A 0.46 6.57 0.34 2e-10 Response to antipsychotic treatment; CRC trans rs8108034 1.000 rs39587 chr19:39806997 C/T cg04089111 chr2:74942655 NA -0.54 -5.97 -0.31 6.18e-9 Lung adenocarcinoma; CRC cis rs6964587 0.935 rs28412174 chr7:91577245 T/G cg17063962 chr7:91808500 NA -0.78 -13.59 -0.6 1.08e-33 Breast cancer; CRC cis rs9616064 0.506 rs737135 chr22:47061791 C/T cg05621596 chr22:47072043 GRAMD4 -0.7 -12.05 -0.55 6.09e-28 Urate levels in obese individuals; CRC cis rs9902453 1.000 rs4465649 chr17:28394747 A/G cg26525008 chr17:28256777 EFCAB5;SSH2 -0.59 -8.8 -0.44 7.78e-17 Coffee consumption (cups per day); CRC cis rs11191205 0.686 rs10786644 chr10:103396646 C/T cg15320455 chr10:103880129 LDB1 0.56 6.19 0.32 1.77e-9 Intelligence (multi-trait analysis); CRC cis rs7781266 0.947 rs11971531 chr7:133538947 C/T cg03336402 chr7:133662267 EXOC4 0.51 6.56 0.34 2.09e-10 Educational attainment (college completion); CRC cis rs832540 0.593 rs252912 chr5:56195792 C/T cg24531977 chr5:56204891 C5orf35 -0.52 -7.81 -0.4 7.62e-14 Coronary artery disease; CRC cis rs910316 1.000 rs7156328 chr14:75532941 T/C cg11812906 chr14:75593930 NEK9 0.62 9.78 0.47 5.54e-20 Height; CRC cis rs11971779 0.680 rs6978680 chr7:139112048 A/G cg23387468 chr7:139079360 LUC7L2 -0.41 -7.04 -0.36 1.14e-11 Diisocyanate-induced asthma; CRC cis rs3862030 0.839 rs2281880 chr10:104269217 G/A cg11453585 chr10:104263688 ACTR1A;SUFU -0.77 -13.33 -0.59 1.03e-32 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for body mass index; CRC cis rs3126085 0.734 rs3120653 chr1:152284854 A/G cg09127314 chr1:152161683 NA -0.46 -5.86 -0.31 1.11e-8 Atopic dermatitis; CRC trans rs1455244 0.700 rs7229302 chr18:11508904 G/T cg01856985 chr12:6798404 ZNF384 0.4 6.21 0.32 1.62e-9 Schizophrenia; CRC cis rs2242116 0.727 rs4683298 chr3:46966387 C/G cg27129171 chr3:47204927 SETD2 0.55 7.86 0.4 5.58e-14 Birth weight; CRC cis rs10193935 0.901 rs9309082 chr2:42581412 A/G cg27598129 chr2:42591480 NA -0.67 -7.56 -0.38 4.02e-13 Colonoscopy-negative controls vs population controls; CRC trans rs1005277 0.579 rs1780115 chr10:38524773 C/T cg23533926 chr12:111358616 MYL2 -0.56 -8.67 -0.43 2e-16 Extrinsic epigenetic age acceleration; CRC cis rs3764563 1.000 rs2031062 chr19:15717573 T/C cg20725493 chr19:15740067 CYP4F8 -0.68 -6.2 -0.32 1.68e-9 Inflammatory biomarkers; CRC cis rs1218582 0.804 rs4845678 chr1:154853295 A/G cg24250549 chr1:154909240 PMVK 0.64 11.06 0.52 2.22e-24 Prostate cancer; CRC cis rs3733585 0.699 rs10001964 chr4:9959275 C/T cg11266682 chr4:10021025 SLC2A9 -0.47 -9.64 -0.47 1.58e-19 Cleft plate (environmental tobacco smoke interaction); CRC cis rs4819052 0.851 rs9974628 chr21:46672647 C/T cg02159808 chr21:46707872 POFUT2;LOC642852 0.5 6.61 0.34 1.53e-10 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs2976388 0.590 rs11785290 chr8:143814849 A/G cg24634471 chr8:143751801 JRK -0.44 -6.17 -0.32 1.99e-9 Urinary tract infection frequency; CRC cis rs970548 0.954 rs12243153 chr10:46002060 T/A cg15590007 chr10:45870220 ALOX5 0.48 6.02 0.31 4.76e-9 Total cholesterol levels;Cholesterol, total;HDL cholesterol;HDL cholesterol levels; CRC cis rs4332037 0.539 rs56180486 chr7:2050747 C/T cg23378565 chr7:2036160 MAD1L1 -0.46 -6.37 -0.33 6.22e-10 Bipolar disorder; CRC cis rs4731207 0.751 rs4584095 chr7:124500210 C/T cg23710748 chr7:124431027 NA -0.38 -6.08 -0.32 3.42e-9 Cutaneous malignant melanoma; CRC cis rs2549003 1.000 rs2549007 chr5:131826875 T/C cg02551604 chr5:131831745 NA 0.57 8.81 0.44 7.42e-17 Asthma (sex interaction); CRC cis rs3760982 1.000 rs11665924 chr19:44286982 G/A cg11993925 chr19:44307056 LYPD5 0.47 7.79 0.39 9e-14 Breast cancer (estrogen-receptor negative);Breast cancer; CRC cis rs13256369 0.951 rs10503394 chr8:8565775 A/G cg06636001 chr8:8085503 FLJ10661 0.48 6.08 0.32 3.28e-9 Obesity-related traits; CRC cis rs4665809 0.680 rs3955310 chr2:26290828 T/G cg25036284 chr2:26402008 FAM59B -0.45 -5.94 -0.31 7.45e-9 Gut microbiome composition (summer); CRC cis rs11690935 1.000 rs312918 chr2:172569587 C/G cg13550731 chr2:172543902 DYNC1I2 -1.07 -19.51 -0.73 6.95e-57 Schizophrenia; CRC cis rs3087591 1.000 rs2905791 chr17:29472888 T/C cg24425628 chr17:29625626 OMG;NF1 0.86 15.89 0.66 1.36e-42 Hip circumference; CRC cis rs892961 0.932 rs3987887 chr17:75414862 T/C cg05865280 chr17:75406074 SEPT9 0.59 12.98 0.58 2.14e-31 Airflow obstruction; CRC cis rs9341808 0.600 rs668329 chr6:80968578 G/A cg08355045 chr6:80787529 NA -0.36 -5.92 -0.31 8.17e-9 Sitting height ratio; CRC cis rs4862750 0.914 rs11945845 chr4:187874136 T/C cg22105103 chr4:187893119 NA 0.61 10.94 0.52 5.54e-24 Lobe attachment (rater-scored or self-reported); CRC cis rs995000 0.931 rs6675401 chr1:63073975 C/T cg19896129 chr1:63156450 NA 0.42 6.53 0.34 2.48e-10 Triglyceride levels; CRC cis rs6662572 0.703 rs9429090 chr1:46502393 A/G cg03123370 chr1:45965343 CCDC163P;MMACHC 0.45 5.79 0.3 1.69e-8 Blood protein levels; CRC cis rs11958404 1.000 rs72816528 chr5:157410949 G/A cg05962755 chr5:157440814 NA 0.83 10.82 0.51 1.57e-23 IgG glycosylation; CRC cis rs6912958 0.559 rs451829 chr6:88041919 A/G cg12350822 chr6:88032061 C6orf162;GJB7 0.49 10.0 0.48 9.99e-21 Monocyte percentage of white cells; CRC cis rs4731207 0.698 rs4731218 chr7:124472015 C/T cg23710748 chr7:124431027 NA -0.38 -6.03 -0.32 4.48e-9 Cutaneous malignant melanoma; CRC cis rs4843747 0.749 rs12102841 chr16:88072574 C/G cg17633681 chr16:88106987 BANP -0.79 -14.0 -0.61 2.89e-35 Menopause (age at onset); CRC trans rs587242 1.000 rs12036050 chr1:96917491 T/C cg10631902 chr5:14652156 NA 0.45 7.05 0.36 1.08e-11 Body mass index (joint analysis main effects and physical activity interaction);Body mass index in physically inactive individuals;Body mass index; CRC cis rs4836694 0.574 rs4837476 chr9:132937533 T/C cg05251000 chr9:132935664 FREQ 0.52 7.88 0.4 4.96e-14 Alzheimer's disease (cognitive decline); CRC cis rs6960043 0.818 rs10238625 chr7:15054232 A/G cg19272540 chr7:15055459 NA 0.24 6.61 0.34 1.55e-10 Type 2 diabetes; CRC cis rs7726839 0.540 rs72705030 chr5:645562 C/T cg14541582 chr5:601475 NA -0.34 -6.61 -0.34 1.52e-10 Obesity-related traits; CRC cis rs4481887 0.800 rs4514268 chr1:248444600 T/G cg13385794 chr1:248469461 NA 0.38 6.56 0.34 2.12e-10 Common traits (Other); CRC cis rs514406 0.560 rs1889033 chr1:53211887 A/G cg08859206 chr1:53392774 SCP2 0.41 6.37 0.33 6.38e-10 Monocyte count; CRC cis rs7677751 0.806 rs1800812 chr4:55094629 G/T cg17187183 chr4:55093834 PDGFRA 0.52 7.37 0.38 1.36e-12 Corneal astigmatism; CRC trans rs7618501 0.966 rs9882639 chr3:49799475 A/C cg21659725 chr3:3221576 CRBN 0.91 17.27 0.69 4.82e-48 Intelligence (multi-trait analysis); CRC cis rs4481887 0.927 rs6678798 chr1:248476617 C/T cg00666640 chr1:248458726 OR2T12 0.45 7.8 0.4 8.31e-14 Common traits (Other); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg17902383 chr17:36891499 PCGF2;CISD3 0.43 6.24 0.33 1.37e-9 Response to antipsychotic treatment; CRC cis rs6502050 0.805 rs4789720 chr17:80157490 G/C cg02741985 chr17:80059408 CCDC57 0.42 6.93 0.36 2.24e-11 Life satisfaction; CRC cis rs6456156 0.774 rs6908364 chr6:167527296 C/T cg19688584 chr6:167529678 CCR6 -0.33 -5.98 -0.31 5.91e-9 Primary biliary cholangitis; CRC cis rs9309711 0.666 rs6767 chr2:3483205 C/T cg15506890 chr2:3487001 NA -0.54 -8.68 -0.43 1.88e-16 Neurofibrillary tangles; CRC cis rs853679 0.517 rs9348797 chr6:28137533 G/C cg12172441 chr6:28176163 NA 0.64 7.53 0.38 5.03e-13 Depression; CRC cis rs965469 0.846 rs7271575 chr20:3333877 C/T cg25506879 chr20:3388711 C20orf194 -0.39 -5.81 -0.31 1.44e-8 IFN-related cytopenia; CRC cis rs10078 0.515 rs890984 chr5:479540 A/G cg07599136 chr5:415885 AHRR 0.68 6.7 0.35 9.19e-11 Fat distribution (HIV); CRC cis rs4819052 0.851 rs8130285 chr21:46671701 G/C cg11663144 chr21:46675770 NA -0.82 -14.31 -0.62 1.82e-36 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs904251 0.861 rs1757183 chr6:37484790 C/T cg01843034 chr6:37503916 NA 0.45 8.38 0.42 1.57e-15 Cognitive performance; CRC cis rs7647973 0.925 rs6808036 chr3:49236439 T/G cg20833759 chr3:49053208 WDR6;DALRD3 0.55 8.44 0.42 1.01e-15 Menarche (age at onset); CRC cis rs1387259 0.929 rs11168484 chr12:48633589 A/C cg21466736 chr12:48725269 NA -0.56 -8.32 -0.42 2.36e-15 Obstructive sleep apnea trait (apnea hypopnea index); CRC cis rs6582630 0.519 rs11495376 chr12:38284957 A/C cg26384229 chr12:38710491 ALG10B 0.69 9.79 0.47 5.01e-20 Drug-induced liver injury (flucloxacillin); CRC cis rs11123170 0.542 rs11123169 chr2:113967075 C/T cg21482265 chr2:113992762 PAX8;LOC440839;LOC654433 -0.45 -6.22 -0.32 1.54e-9 Renal function-related traits (BUN); CRC cis rs3858526 0.628 rs4237762 chr11:5956626 A/C cg26762873 chr11:5879799 OR52E8 -0.42 -6.83 -0.35 4.15e-11 DNA methylation (variation); CRC cis rs1005224 0.853 rs61980778 chr14:76151532 C/T cg04684003 chr14:76127793 TTLL5;C14orf1 0.49 7.0 0.36 1.48e-11 Large artery stroke; CRC cis rs2933343 1.000 rs876755 chr3:128627933 C/T cg11901034 chr3:128598214 ACAD9 -0.51 -6.12 -0.32 2.73e-9 IgG glycosylation; CRC cis rs3741151 1.000 rs74795285 chr11:73033387 A/G cg17517138 chr11:73019481 ARHGEF17 1.02 8.71 0.43 1.46e-16 GIP levels in response to oral glucose tolerance test (120 minutes); CRC cis rs6662572 0.737 rs55652826 chr1:46442678 T/C cg08644498 chr1:46502608 NA 0.46 7.09 0.36 8.14e-12 Blood protein levels; CRC cis rs35306767 0.715 rs17221456 chr10:1037234 T/C cg20503657 chr10:835505 NA 0.92 10.64 0.51 6.63e-23 Eosinophil percentage of granulocytes; CRC cis rs6840360 0.547 rs9991859 chr4:152265572 T/C cg09659197 chr4:152720779 NA 0.33 6.56 0.34 2.11e-10 Intelligence (multi-trait analysis); CRC trans rs916888 0.773 rs199451 chr17:44801784 G/A cg22433210 chr17:43662623 NA 0.97 10.08 0.49 5.26e-21 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs6988985 0.728 rs6471572 chr8:143965264 G/C cg10324643 chr8:143916377 GML 0.38 6.14 0.32 2.44e-9 Plasma androstenedione levels in resected early stage-receptor positive breast cancer; CRC cis rs2274273 0.901 rs112870553 chr14:55790062 T/G cg23234261 chr14:55582407 NA -0.29 -5.78 -0.3 1.75e-8 Protein biomarker; CRC cis rs3733585 0.637 rs6850684 chr4:9964380 G/T cg11266682 chr4:10021025 SLC2A9 -0.47 -9.64 -0.47 1.58e-19 Cleft plate (environmental tobacco smoke interaction); CRC cis rs4713118 0.621 rs9295755 chr6:28033174 C/T cg12172441 chr6:28176163 NA -0.54 -6.65 -0.34 1.2e-10 Parkinson's disease; CRC cis rs896854 0.625 rs13281709 chr8:95972819 T/A cg13393036 chr8:95962371 TP53INP1 -0.54 -9.26 -0.45 2.66e-18 Type 2 diabetes; CRC cis rs9469890 0.604 rs11756281 chr6:34503446 T/C cg17674042 chr6:34482479 PACSIN1 -0.63 -7.45 -0.38 8.35e-13 Pubertal anthropometrics;Coronary artery disease; CRC cis rs2050392 0.894 rs2480277 chr10:30703513 G/T cg25182066 chr10:30743637 MAP3K8 0.4 5.81 0.3 1.51e-8 Inflammatory bowel disease; CRC trans rs7395662 0.517 rs10454483 chr11:48754997 A/G cg03929089 chr4:120376271 NA -0.49 -7.11 -0.36 7.38e-12 HDL cholesterol; CRC trans rs9595908 0.802 rs2010997 chr13:33070506 G/A cg07450633 chr5:172175321 NA 0.37 6.09 0.32 3.12e-9 Body mass index; CRC cis rs3008870 1.000 rs12041926 chr1:67434602 A/G cg08660285 chr1:67390436 MIER1;WDR78 0.99 14.96 0.64 5.61e-39 Lymphocyte percentage of white cells; CRC trans rs2727020 0.930 rs1164688 chr11:49290604 C/G cg03929089 chr4:120376271 NA 0.67 9.35 0.46 1.35e-18 Coronary artery disease; CRC cis rs728616 0.867 rs4633405 chr10:81927446 G/T cg05935833 chr10:81318306 SFTPA2 -0.72 -7.91 -0.4 3.97e-14 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs9914988 0.943 rs4794836 chr17:27082710 C/G cg12682573 chr17:27188876 MIR451;MIR144 -0.56 -8.47 -0.42 8.16e-16 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs12701220 0.655 rs7778968 chr7:1144622 C/G cg02733842 chr7:1102375 C7orf50 -0.59 -7.04 -0.36 1.09e-11 Bronchopulmonary dysplasia; CRC trans rs11343 0.675 rs7359333 chr16:19262344 A/T cg05802477 chr12:132629385 DDX51;NOC4L -0.46 -6.0 -0.31 5.34e-9 Parkinson's disease; CRC cis rs7552404 1.000 rs4949872 chr1:76131392 C/G cg03433033 chr1:76189801 ACADM 0.8 11.1 0.52 1.61e-24 Blood metabolite levels;Acylcarnitine levels; CRC cis rs4363385 0.720 rs1134220 chr1:152976306 T/G cg25856811 chr1:152973957 SPRR3 -0.25 -6.76 -0.35 6.27e-11 Inflammatory skin disease; CRC cis rs3768617 0.510 rs7549768 chr1:183097382 T/G ch.1.3577855R chr1:183094577 LAMC1 0.88 15.3 0.64 2.7e-40 Fuchs's corneal dystrophy; CRC cis rs3126085 0.515 rs11204984 chr1:152331987 T/C cg09127314 chr1:152161683 NA -0.43 -5.68 -0.3 2.99e-8 Atopic dermatitis; CRC trans rs61931739 0.534 rs1844526 chr12:34102780 G/A cg26384229 chr12:38710491 ALG10B 0.54 6.95 0.36 1.99e-11 Morning vs. evening chronotype; CRC cis rs12802200 0.561 rs746707 chr11:571984 C/T cg16486109 chr11:613632 IRF7 0.59 10.51 0.5 1.82e-22 Systemic lupus erythematosus; CRC trans rs7647973 0.587 rs10452032 chr3:49680973 G/A cg21659725 chr3:3221576 CRBN -0.67 -7.34 -0.38 1.72e-12 Menarche (age at onset); CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg19455322 chr3:46735335 ALS2CL -0.39 -6.04 -0.32 4.15e-9 Myopia (pathological); CRC cis rs896854 0.516 rs12679044 chr8:95891356 C/A cg23172400 chr8:95962367 TP53INP1 -0.41 -6.41 -0.33 4.96e-10 Type 2 diabetes; CRC cis rs977987 0.872 rs4887825 chr16:75472422 C/A cg03315344 chr16:75512273 CHST6 0.56 9.57 0.47 2.62e-19 Dupuytren's disease; CRC cis rs7572644 0.640 rs11127126 chr2:28023284 C/T cg27432699 chr2:27873401 GPN1 0.46 6.2 0.32 1.7e-9 Response to carboplatin and paclitaxel in ovarian cancer (Caspase 3/7 EC50); CRC trans rs12599106 0.839 rs3853177 chr16:34498532 A/G cg05064044 chr6:292385 DUSP22 -0.57 -7.86 -0.4 5.4e-14 Menopause (age at onset); CRC trans rs2270927 0.510 rs4352583 chr5:75576716 A/G cg13563193 chr19:33072644 PDCD5 0.65 6.15 0.32 2.24e-9 Mean corpuscular volume; CRC cis rs2836950 0.545 rs8132143 chr21:40584258 A/T cg11890956 chr21:40555474 PSMG1 -0.69 -10.34 -0.5 6.99e-22 Menarche (age at onset); CRC cis rs2811415 0.597 rs13093679 chr3:127726005 T/C cg13719885 chr3:127795394 NA -0.4 -6.05 -0.32 3.97e-9 Lung function (FEV1/FVC); CRC cis rs3204270 0.714 rs7503307 chr17:79674929 C/G cg09655341 chr17:79618100 PDE6G 0.54 6.37 0.33 6.24e-10 Dental caries; CRC cis rs7772486 0.790 rs1062068 chr6:146207465 A/G cg23711669 chr6:146136114 FBXO30 0.71 12.63 0.57 4.24e-30 Lobe attachment (rater-scored or self-reported); CRC cis rs7255436 0.965 rs11666233 chr19:8452045 G/T cg16745616 chr19:8428856 ANGPTL4 -0.46 -7.26 -0.37 2.88e-12 HDL cholesterol; CRC cis rs1348850 0.526 rs7588049 chr2:178390778 C/T cg27490568 chr2:178487706 NA -0.64 -7.3 -0.37 2.19e-12 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs11098499 0.708 rs1546506 chr4:120241240 T/C cg09307838 chr4:120376055 NA 0.62 9.5 0.46 4.59e-19 Corneal astigmatism; CRC cis rs10540 1.000 rs61876334 chr11:487201 T/C cg19913688 chr11:428466 ANO9 -0.73 -7.41 -0.38 1.08e-12 Body mass index; CRC cis rs898097 0.544 rs6502022 chr17:80908652 C/T cg15664640 chr17:80829946 TBCD 0.46 7.53 0.38 5.05e-13 Breast cancer; CRC cis rs13144136 0.748 rs12502077 chr4:10667802 A/C cg10242279 chr4:10666415 CLNK -0.33 -5.67 -0.3 3.07e-8 Resistance to antihypertensive treatment in hypertension; CRC cis rs116095464 0.510 rs73016876 chr5:244475 T/C cg22857025 chr5:266934 NA -1.23 -16.23 -0.67 6.43e-44 Breast cancer; CRC cis rs6076065 0.723 rs6083099 chr20:23358233 A/G cg11657817 chr20:23433608 CST11 -0.42 -6.35 -0.33 6.96e-10 Facial morphology (factor 15, philtrum width); CRC cis rs11971779 0.680 rs7779900 chr7:139082987 G/T cg23387468 chr7:139079360 LUC7L2 0.41 7.04 0.36 1.14e-11 Diisocyanate-induced asthma; CRC cis rs731174 0.802 rs776052 chr1:38179143 C/T cg06917450 chr1:38156652 C1orf109 -0.52 -7.0 -0.36 1.47e-11 Prostate cancer (SNP x SNP interaction); CRC cis rs67311347 1.000 rs73078162 chr3:40477109 G/A cg09455208 chr3:40491958 NA 0.5 9.78 0.47 5.49e-20 Renal cell carcinoma; CRC trans rs6951245 1.000 rs113858334 chr7:1073476 A/G cg13565492 chr6:43139072 SRF -0.71 -7.31 -0.37 2.04e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs10242455 0.702 rs45448997 chr7:99041598 G/C cg18809830 chr7:99032528 PTCD1 -1.03 -7.68 -0.39 1.85e-13 Blood metabolite levels; CRC cis rs7523050 0.643 rs35662800 chr1:109400816 C/A cg08274380 chr1:109419600 GPSM2 0.84 6.6 0.34 1.69e-10 Fat distribution (HIV); CRC cis rs17270561 0.609 rs9393662 chr6:25739670 T/C cg16482183 chr6:26056742 HIST1H1C 0.83 10.58 0.5 1.07e-22 Iron status biomarkers; CRC cis rs67478160 0.619 rs12437066 chr14:104236844 A/C cg08213375 chr14:104286397 PPP1R13B 0.59 12.05 0.55 5.96e-28 Schizophrenia; CRC cis rs10751667 0.666 rs7483273 chr11:951127 T/C ch.11.42038R chr11:967971 AP2A2 0.57 9.76 0.47 6.08e-20 Alzheimer's disease (late onset); CRC cis rs6748734 0.894 rs4675869 chr2:241827696 A/G cg04034577 chr2:241836375 C2orf54 -0.42 -9.01 -0.44 1.69e-17 Urinary metabolites; CRC cis rs2882667 0.728 rs10068766 chr5:138276784 G/A cg09476006 chr5:138032270 NA 0.57 9.74 0.47 7.12e-20 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs7927592 0.763 rs624003 chr11:68231240 C/T cg16797656 chr11:68205561 LRP5 0.51 9.62 0.47 1.82e-19 Total body bone mineral density; CRC cis rs7940866 0.834 rs7939417 chr11:130853832 T/A cg12179176 chr11:130786555 SNX19 0.58 8.52 0.42 6.03e-16 Schizophrenia; CRC cis rs12950390 0.853 rs66471233 chr17:45867086 C/T cg24803719 chr17:45855879 NA -0.31 -6.9 -0.36 2.62e-11 IgG glycosylation; CRC cis rs1784581 0.674 rs1789989 chr6:162408138 C/T cg17173639 chr6:162384350 PARK2 0.59 9.65 0.47 1.47e-19 Itch intensity from mosquito bite; CRC cis rs1862618 0.853 rs252916 chr5:56121788 G/C cg18230493 chr5:56204884 C5orf35 -0.69 -9.12 -0.45 7.72e-18 Initial pursuit acceleration; CRC cis rs172166 0.694 rs9295760 chr6:28147385 G/A cg15845792 chr6:28175446 NA 0.82 12.19 0.56 1.77e-28 Cardiac Troponin-T levels; CRC cis rs1552244 1.000 rs9849434 chr3:10133710 A/G cg00166722 chr3:10149974 C3orf24 -0.64 -8.81 -0.44 7.23e-17 Alzheimer's disease; CRC cis rs4253772 0.530 rs6008662 chr22:46713917 G/A cg24881330 chr22:46731750 TRMU 0.67 7.85 0.4 5.78e-14 LDL cholesterol;Cholesterol, total; CRC cis rs9733 0.519 rs11204717 chr1:150709129 T/A cg18016565 chr1:150552671 MCL1 0.46 6.53 0.34 2.53e-10 Tonsillectomy; CRC trans rs6472827 0.645 rs2956052 chr8:75112658 A/G cg16732884 chr16:2569654 AMDHD2;ATP6V0C 0.38 6.01 0.31 5.02e-9 Uterine fibroids; CRC cis rs6456156 0.586 rs2001114 chr6:167486578 A/G cg07741184 chr6:167504864 NA 0.41 6.93 0.36 2.23e-11 Primary biliary cholangitis; CRC cis rs7113874 0.610 rs11041924 chr11:8463107 C/T cg17679104 chr11:8615758 STK33 -0.35 -5.87 -0.31 1.07e-8 Body mass index in physically active individuals;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs9399135 0.933 rs7755680 chr6:135294259 A/G cg22676075 chr6:135203613 NA 0.42 6.41 0.33 5.13e-10 Red blood cell count; CRC cis rs9875589 1.000 rs9875589 chr3:13961157 A/C cg19554555 chr3:13937349 NA 0.45 6.78 0.35 5.47e-11 Ovarian reserve; CRC cis rs72772090 0.539 rs11750934 chr5:96118487 A/C cg17330273 chr5:96107758 CAST;ERAP1 -0.63 -5.77 -0.3 1.79e-8 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs9486715 1.000 rs11153082 chr6:97059666 A/G cg06623918 chr6:96969491 KIAA0776 -0.98 -17.96 -0.7 9.76e-51 Headache; CRC cis rs6933660 0.666 rs9371516 chr6:151739642 G/A cg14262678 chr6:151773367 RMND1;C6orf211 0.5 8.21 0.41 5.2e-15 Menarche (age at onset); CRC cis rs4664293 0.609 rs10209829 chr2:160447624 A/T cg08347373 chr2:160653686 CD302 -0.38 -6.48 -0.34 3.42e-10 Monocyte percentage of white cells; CRC cis rs7474896 0.583 rs10764144 chr10:37975732 G/C cg25427524 chr10:38739819 LOC399744 -0.54 -6.67 -0.35 1.05e-10 Obesity (extreme); CRC cis rs34526934 0.608 rs7606110 chr2:177028551 T/C cg14324370 chr2:177042789 NA -0.69 -9.33 -0.46 1.62e-18 Obstructive sleep apnea trait (apnea hypopnea index); CRC cis rs7904368 0.568 rs10752061 chr10:16853900 A/G cg23933602 chr10:16859644 RSU1 0.75 11.98 0.55 1.12e-27 Ratio of the peak velocity of the mitral E-Wave divided by the peak velocity of the mitral A-wave.; CRC cis rs7394190 0.748 rs3740293 chr10:75406141 A/C cg07699608 chr10:75541558 CHCHD1 0.57 6.5 0.34 3.06e-10 Incident atrial fibrillation; CRC cis rs11098499 0.866 rs12501602 chr4:120287935 A/T cg09307838 chr4:120376055 NA 0.68 10.39 0.5 4.73e-22 Corneal astigmatism; CRC trans rs7615952 0.512 rs11929125 chr3:125359443 G/A cg17147758 chr8:6949321 NA -0.52 -7.2 -0.37 4.24e-12 Blood pressure (smoking interaction); CRC cis rs10504229 0.683 rs11786845 chr8:58133642 T/C cg24829409 chr8:58192753 C8orf71 -0.56 -8.31 -0.42 2.48e-15 Developmental language disorder (linguistic errors); CRC cis rs3820068 0.581 rs16849152 chr1:15921774 A/C cg27534772 chr1:16042836 PLEKHM2 0.54 10.43 0.5 3.54e-22 Systolic blood pressure; CRC cis rs6502050 0.835 rs7213172 chr17:80085703 G/T cg02741985 chr17:80059408 CCDC57 -0.44 -7.15 -0.37 5.61e-12 Life satisfaction; CRC cis rs7119 0.717 rs12904584 chr15:77815991 C/T cg27398640 chr15:77910606 LINGO1 -0.43 -7.47 -0.38 7.13e-13 Type 2 diabetes; CRC cis rs12887734 0.524 rs12888002 chr14:104238647 T/C cg08213375 chr14:104286397 PPP1R13B 0.48 7.76 0.39 1.11e-13 Schizophrenia;Autism spectrum disorder or schizophrenia; CRC cis rs1552244 1.000 rs722509 chr3:10102377 T/A cg02579736 chr3:10068473 FANCD2;CIDECP 1.02 13.77 0.6 2.25e-34 Alzheimer's disease; CRC cis rs7917772 0.599 rs2863717 chr10:104519829 A/G cg22532475 chr10:104410764 TRIM8 0.33 5.71 0.3 2.53e-8 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC trans rs7824557 0.603 rs2250028 chr8:11213589 T/G cg06636001 chr8:8085503 FLJ10661 0.45 6.6 0.34 1.65e-10 Retinal vascular caliber; CRC cis rs1129187 1.000 rs1129187 chr6:42932200 G/T cg27588902 chr6:42928151 GNMT -0.38 -6.81 -0.35 4.59e-11 Alzheimer's disease in APOE e4+ carriers; CRC cis rs8078723 0.966 rs2227322 chr17:38171668 C/G cg17467752 chr17:38218738 THRA 0.73 11.97 0.55 1.17e-27 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); CRC cis rs9435341 0.965 rs1730864 chr1:107607810 C/T cg15468180 chr1:107600409 PRMT6 -0.44 -6.6 -0.34 1.65e-10 Facial morphology (factor 21, depth of nasal alae); CRC cis rs58141407 1 rs58141407 chr8:21791772 C/T cg12468850 chr8:21767224 DOK2 -0.55 -5.98 -0.31 5.93e-9 Red blood cell count;Mean corpuscular volume; CRC cis rs9463078 0.764 rs9369513 chr6:44789476 T/C cg25276700 chr6:44698697 NA -0.26 -6.42 -0.33 4.75e-10 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; CRC cis rs1799949 0.602 rs8176235 chr17:41219560 C/T cg19454999 chr17:41278357 BRCA1;NBR2 0.46 6.29 0.33 1.01e-9 Menopause (age at onset); CRC cis rs72634258 0.945 rs12745223 chr1:8094978 C/T cg00042356 chr1:8021962 PARK7 0.66 7.01 0.36 1.39e-11 Inflammatory bowel disease; CRC cis rs1799949 0.501 rs9675035 chr17:41415016 A/T cg23758822 chr17:41437982 NA 0.79 13.4 0.59 5.5e-33 Menopause (age at onset); CRC cis rs2303745 0.589 rs1465576 chr19:17398487 G/A cg15110403 chr19:17392923 ANKLE1 -0.35 -5.65 -0.3 3.51e-8 Systemic lupus erythematosus; CRC cis rs6964587 0.967 rs6973896 chr7:91778465 A/G cg17063962 chr7:91808500 NA 0.84 14.85 0.63 1.52e-38 Breast cancer; CRC trans rs951252 0.504 rs11734405 chr4:146081096 C/T cg01866215 chr16:3150293 NA -0.48 -5.98 -0.31 5.94e-9 Hip circumference; CRC cis rs614226 0.744 rs787832 chr12:120986801 A/G cg27489772 chr12:121021490 NA 0.49 6.85 0.35 3.59e-11 Type 1 diabetes nephropathy; CRC cis rs9311474 1.000 rs1060330 chr3:52288945 T/C cg08222913 chr3:52553049 STAB1 -0.35 -6.64 -0.34 1.29e-10 Electroencephalogram traits; CRC cis rs4664293 0.625 rs7607394 chr2:160563797 G/A cg08347373 chr2:160653686 CD302 0.39 6.53 0.34 2.44e-10 Monocyte percentage of white cells; CRC cis rs875971 0.798 rs7789615 chr7:65878661 A/G cg11764359 chr7:65958608 NA 0.57 8.44 0.42 1.01e-15 Aortic root size; CRC cis rs13118159 0.742 rs34947293 chr4:1335034 T/C cg20092199 chr4:1342459 KIAA1530 0.45 8.15 0.41 7.71e-15 Longevity; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg11855759 chr17:9548802 USP43 0.47 7.76 0.39 1.06e-13 Liver disease severity in Alagille syndrome; CRC cis rs8060686 0.858 rs11553287 chr16:67905407 A/G cg19582491 chr16:67682965 RLTPR -0.4 -5.69 -0.3 2.84e-8 HDL cholesterol;Metabolic syndrome; CRC trans rs6951245 0.554 rs11544331 chr7:1131411 C/T cg13565492 chr6:43139072 SRF -0.84 -10.52 -0.5 1.72e-22 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs4819052 0.851 rs28442024 chr21:46674475 C/A cg19498844 chr21:46707878 POFUT2;LOC642852 0.75 10.64 0.51 6.57e-23 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs10229583 0.527 rs6943219 chr7:127308386 A/G cg01233922 chr7:127693937 SND1 -0.47 -7.34 -0.38 1.65e-12 Type 2 diabetes; CRC cis rs2075371 0.897 rs1646733 chr7:134002228 C/A cg02659138 chr7:134003124 SLC35B4 0.41 7.13 0.37 6.38e-12 Mean platelet volume; CRC cis rs9487051 0.676 rs9386788 chr6:109600523 C/T cg01475377 chr6:109611718 NA 0.36 6.39 0.33 5.51e-10 Reticulocyte fraction of red cells; CRC cis rs172166 0.694 rs188105 chr6:28071393 C/T cg10876282 chr6:28092338 ZSCAN16 0.5 6.72 0.35 7.89e-11 Cardiac Troponin-T levels; CRC cis rs537626 1.000 rs537626 chr11:69307695 C/G cg08353955 chr11:69289746 NA 0.54 5.83 0.31 1.3e-8 Breast cancer (early onset); CRC cis rs76878669 0.515 rs947978 chr11:66108660 C/T cg18002602 chr11:66138449 SLC29A2 0.27 5.82 0.31 1.38e-8 Educational attainment (years of education); CRC cis rs7927592 0.913 rs10896347 chr11:68353127 G/A cg01657329 chr11:68192670 LRP5 -0.47 -6.79 -0.35 5.16e-11 Total body bone mineral density; CRC cis rs2721195 0.967 rs748195 chr8:145682514 T/C cg26752003 chr8:145688521 CYHR1 -0.54 -9.04 -0.45 1.35e-17 Age at first birth; CRC trans rs1814175 0.645 rs11040661 chr11:49952146 G/T cg15704280 chr7:45808275 SEPT13 -0.94 -16.66 -0.68 1.23e-45 Height; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg08316558 chr5:141229648 NA 0.43 6.3 0.33 9.48e-10 Intelligence (multi-trait analysis); CRC trans rs629535 0.725 rs639127 chr8:70073251 A/G cg21567404 chr3:27674614 NA 0.92 15.32 0.65 2.38e-40 Dupuytren's disease; CRC cis rs1448094 0.838 rs11834294 chr12:86311958 C/T cg02569458 chr12:86230093 RASSF9 0.35 5.84 0.31 1.25e-8 Major depressive disorder; CRC cis rs11122272 0.735 rs2474623 chr1:231513993 T/C cg06096015 chr1:231504339 EGLN1 0.4 5.95 0.31 6.7e-9 Hemoglobin concentration; CRC cis rs3741404 0.609 rs641378 chr11:63869493 T/C cg05016508 chr11:63871570 FLRT1;MACROD1 0.53 8.87 0.44 4.6e-17 Platelet count; CRC trans rs459571 0.839 rs10993895 chr9:136887726 C/T cg15028160 chr19:49622717 PPFIA3;C19orf73 0.58 7.4 0.38 1.18e-12 Platelet distribution width; CRC cis rs12476592 0.602 rs10865337 chr2:63720906 C/T cg10828910 chr2:63850056 LOC388955 0.48 5.8 0.3 1.54e-8 Childhood ear infection; CRC cis rs13191362 1.000 rs73016459 chr6:163066323 C/A cg21926612 chr6:163149169 PACRG;PARK2 0.97 12.69 0.57 2.66e-30 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs9547692 0.877 rs12020203 chr13:37469287 G/A cg01493522 chr13:37497338 NA -0.52 -7.16 -0.37 5.21e-12 Coronary artery disease; CRC cis rs2425143 1.000 rs11696369 chr20:34378629 C/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.48 -6.08 -0.32 3.36e-9 Blood protein levels; CRC cis rs17711722 0.510 rs73142128 chr7:65331109 A/C cg02869306 chr7:64672164 INTS4L1 -0.43 -7.02 -0.36 1.29e-11 Calcium levels; CRC cis rs1568889 1.000 rs7931847 chr11:28175245 G/T cg06544937 chr11:28130018 METT5D1;KIF18A 0.78 10.98 0.52 4.29e-24 Bipolar disorder; CRC trans rs7615952 0.512 rs2979351 chr3:125363599 C/T cg00769240 chr8:12517080 NA -0.74 -10.17 -0.49 2.71e-21 Blood pressure (smoking interaction); CRC cis rs2282802 0.685 rs7715538 chr5:139665181 T/C cg26211634 chr5:139558579 C5orf32 0.41 6.9 0.36 2.69e-11 Intelligence (multi-trait analysis); CRC cis rs6752107 0.935 rs10929322 chr2:234149702 A/G cg07618928 chr2:234183455 ATG16L1;SCARNA5 -0.57 -9.06 -0.45 1.16e-17 Crohn's disease;Inflammatory bowel disease; CRC cis rs1799949 0.894 rs71367985 chr17:41374463 G/A cg23758822 chr17:41437982 NA 0.86 16.02 0.66 4.32e-43 Menopause (age at onset); CRC cis rs644799 0.965 rs3016295 chr11:95554311 A/G cg03916912 chr11:95522834 CEP57;FAM76B 0.95 18.01 0.7 5.83e-51 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs9649213 0.593 rs7803372 chr7:97992257 A/G cg21770322 chr7:97807741 LMTK2 0.51 8.38 0.42 1.54e-15 Prostate cancer (SNP x SNP interaction); CRC cis rs6662572 0.703 rs4660890 chr1:46297452 G/C cg03123370 chr1:45965343 CCDC163P;MMACHC -0.48 -6.09 -0.32 3.11e-9 Blood protein levels; CRC cis rs8031584 0.723 rs11632229 chr15:31179534 A/G cg14829155 chr15:31115871 NA 0.54 9.0 0.44 1.91e-17 Huntington's disease progression; CRC cis rs4731207 0.698 rs28409696 chr7:124562515 T/C cg23710748 chr7:124431027 NA -0.37 -5.99 -0.31 5.5e-9 Cutaneous malignant melanoma; CRC cis rs7618915 0.501 rs12635140 chr3:52738165 C/T cg18404041 chr3:52824283 ITIH1 0.4 8.29 0.42 2.83e-15 Bipolar disorder; CRC cis rs2841277 0.741 rs9672139 chr14:105408182 T/G cg14403583 chr14:105418241 AHNAK2 -0.36 -6.61 -0.34 1.52e-10 Rheumatoid arthritis; CRC cis rs4862750 0.872 rs6836781 chr4:187899701 G/A cg06074448 chr4:187884817 NA -0.6 -11.3 -0.53 2.95e-25 Lobe attachment (rater-scored or self-reported); CRC trans rs12554020 0.685 rs55893789 chr9:96170890 T/G cg23291280 chr19:31847970 NA -0.68 -6.24 -0.33 1.36e-9 Schizophrenia; CRC cis rs7737355 0.947 rs31257 chr5:130828715 C/G cg06307176 chr5:131281290 NA 0.41 6.02 0.31 4.78e-9 Life satisfaction; CRC cis rs7829975 0.626 rs907183 chr8:8729761 C/G cg08975724 chr8:8085496 FLJ10661 -0.42 -6.38 -0.33 5.88e-10 Mood instability; CRC trans rs3733585 0.638 rs7377625 chr4:9953099 T/C cg26043149 chr18:55253948 FECH -0.5 -7.71 -0.39 1.54e-13 Cleft plate (environmental tobacco smoke interaction); CRC cis rs7772486 0.641 rs2777485 chr6:146334377 G/A cg23711669 chr6:146136114 FBXO30 0.55 7.87 0.4 5.15e-14 Lobe attachment (rater-scored or self-reported); CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg18970754 chr14:74079533 NA 0.38 6.45 0.34 3.93e-10 Obesity-related traits; CRC cis rs9488822 0.676 rs10456902 chr6:116333742 C/G cg26893134 chr6:116381904 FRK -0.25 -7.25 -0.37 2.94e-12 Cholesterol, total;LDL cholesterol; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg17841838 chr19:3626645 C19orf29 0.42 6.8 0.35 4.82e-11 Liver disease severity in Alagille syndrome; CRC cis rs11112613 0.713 rs4015312 chr12:105948757 A/G cg03607813 chr12:105948248 NA 0.85 9.88 0.48 2.41e-20 Corrected insulin response;Corrected insulin response adjusted for insulin sensitivity index; CRC cis rs2573652 0.723 rs2727201 chr15:100515311 A/G cg00587665 chr15:100533223 ADAMTS17 -0.46 -7.97 -0.4 2.68e-14 Height; CRC cis rs10416265 0.527 rs6510337 chr19:33545701 C/T cg27124370 chr19:33622961 WDR88 0.47 7.03 0.36 1.17e-11 Bone properties (heel); CRC trans rs11764590 0.694 rs10235664 chr7:2086814 T/C cg11693508 chr17:37793320 STARD3 0.45 6.15 0.32 2.21e-9 Neuroticism; CRC cis rs13108904 0.870 rs1960426 chr4:1274365 C/T cg02018176 chr4:1364513 KIAA1530 0.41 6.91 0.36 2.47e-11 Obesity-related traits; CRC cis rs1996152 0.543 rs4789658 chr17:72389526 A/T cg23221732 chr17:72383708 NA 0.42 6.86 0.35 3.43e-11 Interleukin-12p70 levels; CRC cis rs12824058 0.798 rs4759652 chr12:130808771 C/T cg26677194 chr12:130822605 PIWIL1 0.45 7.21 0.37 3.98e-12 Menopause (age at onset); CRC cis rs5753618 0.561 rs2413047 chr22:31666026 A/G cg07713946 chr22:31675144 LIMK2 -0.4 -5.68 -0.3 2.98e-8 Colorectal cancer; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg03498888 chr3:50649296 CISH 0.38 6.07 0.32 3.53e-9 Liver disease severity in Alagille syndrome; CRC cis rs28386778 0.897 rs2727320 chr17:61865325 T/C cg06873352 chr17:61820015 STRADA 0.8 15.32 0.65 2.36e-40 Prudent dietary pattern; CRC cis rs1005277 0.522 rs1208684 chr10:38093936 G/A cg25427524 chr10:38739819 LOC399744 -0.73 -12.68 -0.57 2.92e-30 Extrinsic epigenetic age acceleration; CRC cis rs1129187 0.967 rs3805951 chr6:42937176 C/A cg02353165 chr6:42928485 GNMT 0.85 15.48 0.65 5.3e-41 Alzheimer's disease in APOE e4+ carriers; CRC cis rs6570726 0.791 rs4896820 chr6:145894957 T/C cg13319975 chr6:146136371 FBXO30 -0.39 -5.77 -0.3 1.85e-8 Lobe attachment (rater-scored or self-reported); CRC cis rs290268 0.874 rs290991 chr9:93561450 A/C cg02608019 chr9:93564028 SYK -0.47 -7.5 -0.38 6.17e-13 Platelet count; CRC cis rs477895 0.653 rs11231701 chr11:63893702 G/A cg18225595 chr11:63971243 STIP1 0.56 7.25 0.37 3.04e-12 Mean platelet volume; CRC cis rs72945132 0.882 rs4567496 chr11:70193208 A/T cg00319359 chr11:70116639 PPFIA1 0.66 6.58 0.34 1.83e-10 Coronary artery disease; CRC trans rs1005277 0.579 rs1740735 chr10:38497777 A/C cg17830980 chr10:43048298 ZNF37B -0.57 -9.59 -0.47 2.22e-19 Extrinsic epigenetic age acceleration; CRC cis rs1790761 0.900 rs1638564 chr11:67223920 C/G cg17375396 chr11:67202808 RPS6KB2 0.33 5.65 0.3 3.4e-8 Mean corpuscular volume; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg21525449 chr1:156571403 GPATCH4 0.5 6.51 0.34 2.81e-10 Thyroid stimulating hormone; CRC cis rs11785400 0.762 rs9694556 chr8:143727841 A/G cg24634471 chr8:143751801 JRK 0.51 7.06 0.36 1.01e-11 Schizophrenia; CRC cis rs60871478 0.786 rs62432898 chr7:826102 G/A cg13798912 chr7:905769 UNC84A 0.51 5.81 0.31 1.45e-8 Cerebrospinal P-tau181p levels; CRC cis rs3749237 0.595 rs6784820 chr3:49450864 C/T cg07636037 chr3:49044803 WDR6 -0.56 -8.15 -0.41 7.89e-15 Resting heart rate; CRC cis rs7811142 0.779 rs77370288 chr7:99947897 A/T cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.12 15.74 0.66 5.29e-42 Platelet count; CRC cis rs7072216 0.881 rs7916469 chr10:100148653 T/C cg26618903 chr10:100175079 PYROXD2 -0.37 -6.2 -0.32 1.72e-9 Metabolite levels; CRC trans rs2235573 0.551 rs139897 chr22:38399098 A/G cg19894588 chr14:64061835 NA 0.58 8.32 0.42 2.36e-15 Glioblastoma;Glioma; CRC cis rs9443189 0.901 rs2038625 chr6:76560968 G/A cg01950844 chr6:76311363 SENP6 -0.62 -7.41 -0.38 1.04e-12 Prostate cancer; CRC cis rs12476592 0.602 rs10865339 chr2:63811884 G/T cg10828910 chr2:63850056 LOC388955 0.51 6.3 0.33 9.52e-10 Childhood ear infection; CRC cis rs1215050 0.716 rs356549 chr4:98699344 A/G cg05340658 chr4:99064831 C4orf37 0.48 7.13 0.37 6.27e-12 Waist-to-hip ratio adjusted for body mass index; CRC cis rs7715806 0.500 rs72633983 chr5:75002845 C/T cg19683494 chr5:74908142 NA 0.53 5.76 0.3 1.88e-8 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs6912958 1.000 rs2207144 chr6:88150816 A/G cg12350822 chr6:88032061 C6orf162;GJB7 -0.36 -6.86 -0.35 3.37e-11 Monocyte percentage of white cells; CRC cis rs1707322 0.638 rs9429095 chr1:46603348 A/C cg03146154 chr1:46216737 IPP -0.46 -5.8 -0.3 1.58e-8 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs17270561 0.609 rs4712960 chr6:25727265 C/T cg17691542 chr6:26056736 HIST1H1C 0.73 9.31 0.46 1.82e-18 Iron status biomarkers; CRC cis rs1552244 0.608 rs3732962 chr3:10048951 T/C cg08888203 chr3:10149979 C3orf24 0.48 7.33 0.37 1.74e-12 Alzheimer's disease; CRC cis rs4237845 0.537 rs9645819 chr12:58270063 T/C cg00677455 chr12:58241039 CTDSP2 0.77 11.59 0.54 2.93e-26 Intelligence (multi-trait analysis); CRC cis rs12188164 0.965 rs56146525 chr5:442571 A/C cg21972741 chr5:435613 AHRR 0.55 7.44 0.38 9.07e-13 Cystic fibrosis severity; CRC cis rs6502050 0.799 rs28376857 chr17:80104351 G/A cg09264619 chr17:80180166 NA -0.34 -5.81 -0.3 1.5e-8 Life satisfaction; CRC cis rs12476592 0.602 rs262485 chr2:63878413 T/G cg10828910 chr2:63850056 LOC388955 0.5 6.31 0.33 8.92e-10 Childhood ear infection; CRC cis rs7103648 0.966 rs896817 chr11:47394305 A/G cg20307385 chr11:47447363 PSMC3 -0.94 -16.7 -0.68 8.87e-46 Diastolic blood pressure;Systolic blood pressure; CRC cis rs1832871 0.683 rs11752399 chr6:158711188 G/A cg07165851 chr6:158734300 TULP4 0.62 7.75 0.39 1.18e-13 Height; CRC cis rs7901135 0.962 rs9416744 chr10:60567937 A/C cg23799393 chr10:60588674 BICC1 0.37 5.74 0.3 2.13e-8 Morning vs. evening chronotype; CRC cis rs9611565 0.512 rs6002474 chr22:42168181 A/G cg17554472 chr22:41940697 POLR3H 0.56 5.65 0.3 3.4e-8 Vitiligo; CRC cis rs2243480 1.000 rs313813 chr7:65503500 C/T cg25985355 chr7:65971099 NA -0.52 -5.92 -0.31 8.07e-9 Diabetic kidney disease; CRC cis rs250677 0.687 rs250674 chr5:148438597 A/G cg23229984 chr5:148520753 ABLIM3 -0.5 -6.85 -0.35 3.59e-11 Breast cancer; CRC trans rs7726839 0.574 rs11134149 chr5:637277 A/G cg25482853 chr8:67687455 SGK3 1.01 12.71 0.57 2.25e-30 Obesity-related traits; CRC cis rs2281845 0.965 rs7516023 chr1:201085521 C/T cg22815214 chr1:201083145 CACNA1S 0.63 10.44 0.5 3.06e-22 Permanent tooth development; CRC cis rs9549260 0.522 rs4245401 chr13:41277736 G/T cg21288729 chr13:41239152 FOXO1 0.43 6.76 0.35 6.47e-11 Red blood cell count; CRC cis rs11212617 0.967 rs1003624 chr11:108152645 A/G cg14761454 chr11:108092087 ATM;NPAT 0.42 6.15 0.32 2.28e-9 Response to metformin in type 2 diabetes (glycemic); CRC trans rs2303319 0.504 rs62189054 chr2:162624654 C/G cg10498984 chr16:28874827 SH2B1 -0.73 -6.28 -0.33 1.04e-9 Cognitive function; CRC cis rs2760061 0.583 rs708121 chr1:228208257 A/G cg02753203 chr1:228287806 NA 0.88 13.16 0.59 4.72e-32 Diastolic blood pressure; CRC cis rs2731664 0.792 rs335435 chr5:176867943 A/G cg23176889 chr5:176863531 GRK6 -0.74 -15.71 -0.65 6.92e-42 Intelligence (multi-trait analysis); CRC cis rs6089584 0.830 rs4925331 chr20:60580174 T/C cg06108461 chr20:60628389 TAF4 -0.71 -12.09 -0.55 4.33e-28 Body mass index; CRC cis rs4689388 0.926 rs28420833 chr4:6279504 G/A cg00701064 chr4:6280414 WFS1 0.77 13.58 0.6 1.21e-33 Type 2 diabetes and other traits;Type 2 diabetes; CRC trans rs12639288 0.962 rs12638639 chr3:167660757 C/T cg24786176 chr4:113153431 AP1AR -0.52 -5.97 -0.31 6.27e-9 Hirschsprung disease; CRC cis rs9914544 1.000 rs1037036 chr17:18764077 C/T cg26378065 chr17:18585709 ZNF286B 0.45 5.83 0.31 1.31e-8 Educational attainment (years of education); CRC cis rs796364 0.951 rs7608668 chr2:201000017 T/C cg23649088 chr2:200775458 C2orf69 -0.57 -6.34 -0.33 7.48e-10 Schizophrenia; CRC cis rs1499614 1.000 rs2707840 chr7:66158015 C/T cg18252515 chr7:66147081 NA -1.24 -14.6 -0.63 1.48e-37 Gout; CRC cis rs9814567 0.896 rs7653880 chr3:134345788 T/C cg06109529 chr3:134205091 CEP63;ANAPC13 -0.67 -9.59 -0.47 2.35e-19 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs7772486 0.754 rs9390356 chr6:146118983 A/T cg13319975 chr6:146136371 FBXO30 0.44 6.38 0.33 6.1e-10 Lobe attachment (rater-scored or self-reported); CRC cis rs12760731 0.565 rs10494511 chr1:178094265 A/G cg00404053 chr1:178313656 RASAL2 0.92 9.95 0.48 1.46e-20 Obesity-related traits; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg13559099 chr11:62554740 TMEM179B;TAF6L 0.4 6.63 0.34 1.41e-10 Liver disease severity in Alagille syndrome; CRC cis rs365302 1.000 rs369160 chr6:159638579 T/C cg14500486 chr6:159655392 FNDC1 0.47 7.24 0.37 3.25e-12 Coronary heart disease; CRC cis rs4285028 0.948 rs73855480 chr3:121676646 A/G cg20356878 chr3:121714668 ILDR1 -0.48 -6.95 -0.36 1.93e-11 Multiple sclerosis; CRC cis rs4853036 0.951 rs13393656 chr2:70119255 C/A cg02498382 chr2:70120550 SNRNP27 -0.43 -6.57 -0.34 1.94e-10 Colorectal or endometrial cancer; CRC cis rs6604026 0.656 rs2811597 chr1:93341153 G/A cg17283838 chr1:93427260 FAM69A -0.43 -5.6 -0.3 4.52e-8 Multiple sclerosis; CRC trans rs7618501 0.602 rs2301166 chr3:50148305 C/G cg21659725 chr3:3221576 CRBN -0.55 -8.75 -0.43 1.09e-16 Intelligence (multi-trait analysis); CRC cis rs6933660 0.683 rs6916340 chr6:151779064 T/C cg17179660 chr6:151773299 C6orf211;RMND1 -0.44 -6.81 -0.35 4.64e-11 Menarche (age at onset); CRC cis rs875971 0.862 rs35034167 chr7:65580166 C/G cg12463550 chr7:65579703 CRCP -0.52 -7.4 -0.38 1.14e-12 Aortic root size; CRC cis rs1153858 1.000 rs7402650 chr15:45701895 C/T cg14582100 chr15:45693742 SPATA5L1 0.28 5.62 0.3 4.16e-8 Homoarginine levels; CRC cis rs9430161 0.579 rs10864486 chr1:11040979 A/G cg27631724 chr1:11040367 C1orf127 0.36 7.23 0.37 3.44e-12 Ewing sarcoma; CRC trans rs6598955 0.671 rs7550997 chr1:26596080 G/A cg07461501 chr17:79650226 HGS;ARL16 -0.52 -6.19 -0.32 1.8e-9 Obesity-related traits; CRC cis rs7605827 0.930 rs6431699 chr2:15540281 A/G cg19274914 chr2:15703543 NA 0.4 5.94 0.31 7.2e-9 Educational attainment (years of education); CRC cis rs947211 0.846 rs708726 chr1:205762139 G/T cg11965913 chr1:205819406 PM20D1 -0.46 -6.77 -0.35 6.03e-11 Parkinson's disease; CRC cis rs2251381 0.515 rs2832299 chr21:30749237 G/C cg08807101 chr21:30365312 RNF160 0.48 7.23 0.37 3.41e-12 Selective IgA deficiency; CRC cis rs1559088 0.600 rs10423965 chr19:33600319 T/G cg27124370 chr19:33622961 WDR88 0.47 6.88 0.35 3.01e-11 Bone ultrasound measurement (broadband ultrasound attenuation); CRC trans rs8141529 0.507 rs5762936 chr22:29381377 A/G cg20988775 chr15:25315425 SNORD116-8 -0.49 -6.1 -0.32 3.02e-9 Lymphocyte counts; CRC cis rs2066819 1.000 rs2695782 chr12:56722830 C/T cg26714650 chr12:56694279 CS 1.11 13.18 0.59 3.94e-32 Psoriasis vulgaris; CRC trans rs7613875 0.521 rs4688754 chr3:50074641 G/T cg21665057 chr3:196295764 WDR53;FBXO45 -0.44 -6.39 -0.33 5.66e-10 Body mass index; CRC cis rs2976388 0.566 rs2585146 chr8:143798641 A/C cg05569086 chr8:143859399 LYNX1 0.47 7.61 0.39 2.83e-13 Urinary tract infection frequency; CRC cis rs763121 0.853 rs5750622 chr22:38956464 C/G cg06544989 chr22:39130855 UNC84B 0.42 6.28 0.33 1.1e-9 Menopause (age at onset); CRC cis rs9814567 1.000 rs9863786 chr3:134247203 C/G cg06109529 chr3:134205091 CEP63;ANAPC13 -0.81 -12.17 -0.56 2.25e-28 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs72615157 0.634 rs11762932 chr7:99792666 C/T cg00814883 chr7:100076585 TSC22D4 0.54 6.5 0.34 2.91e-10 Lung function (FEV1/FVC); CRC cis rs477895 0.653 rs3824854 chr11:63885305 C/T cg19465662 chr11:63993652 NUDT22;TRPT1 0.73 9.02 0.45 1.6e-17 Mean platelet volume; CRC cis rs10971721 0.731 rs72725388 chr9:33864622 A/G cg13495928 chr9:33750294 PRSS3 0.56 5.95 0.31 6.96e-9 Body mass index; CRC cis rs6952808 1.000 rs4719319 chr7:1888094 G/A cg00106254 chr7:1943704 MAD1L1 -0.46 -6.48 -0.34 3.29e-10 Bipolar disorder and schizophrenia; CRC cis rs951366 0.617 rs708727 chr1:205767885 G/A cg14159672 chr1:205819179 PM20D1 0.93 15.35 0.65 1.82e-40 Menarche (age at onset); CRC trans rs9929218 1.000 rs12930371 chr16:68802936 A/G cg04657470 chr2:198365150 HSPE1;HSPD1 0.82 11.7 0.54 1.15e-26 Colorectal cancer; CRC cis rs896854 0.714 rs6471503 chr8:95990283 G/A cg16049864 chr8:95962084 TP53INP1 -0.65 -11.82 -0.55 4.13e-27 Type 2 diabetes; CRC cis rs2933343 0.729 rs1683816 chr3:128651195 G/T cg11901034 chr3:128598214 ACAD9 0.53 7.72 0.39 1.39e-13 IgG glycosylation; CRC cis rs2153535 0.580 rs9379206 chr6:8458021 C/A cg07606381 chr6:8435919 SLC35B3 0.69 11.15 0.52 1.04e-24 Motion sickness; CRC cis rs270601 0.683 rs81598 chr5:131587960 C/G cg18758796 chr5:131593413 PDLIM4 0.49 8.22 0.41 4.76e-15 Acylcarnitine levels; CRC trans rs10838798 0.504 rs11039627 chr11:48293931 C/T cg15704280 chr7:45808275 SEPT13 -0.48 -6.65 -0.34 1.23e-10 Height; CRC cis rs7493 0.950 rs17879277 chr7:95030632 A/C cg07404485 chr7:94953653 PON1 -0.47 -6.14 -0.32 2.38e-9 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs7394190 0.810 rs7394152 chr10:75421446 C/T cg07699608 chr10:75541558 CHCHD1 0.58 6.21 0.32 1.56e-9 Incident atrial fibrillation; CRC cis rs612683 0.518 rs565590 chr1:100846956 T/C cg06223162 chr1:101003688 GPR88 0.39 7.14 0.37 5.91e-12 Breast cancer; CRC cis rs9467711 0.651 rs35378061 chr6:26059157 C/A cg08501292 chr6:25962987 TRIM38 0.89 8.35 0.42 1.87e-15 Autism spectrum disorder or schizophrenia; CRC cis rs972578 0.747 rs5996242 chr22:43230627 T/C cg01576275 chr22:43409880 NA -0.4 -6.22 -0.32 1.49e-9 Mean platelet volume; CRC cis rs4664293 0.967 rs2357526 chr2:160524596 C/T cg08347373 chr2:160653686 CD302 0.38 6.17 0.32 1.95e-9 Monocyte percentage of white cells; CRC cis rs10504229 0.683 rs55645894 chr8:58116145 A/G cg24829409 chr8:58192753 C8orf71 -0.55 -8.03 -0.4 1.71e-14 Developmental language disorder (linguistic errors); CRC cis rs992157 0.710 rs6752254 chr2:219058743 C/T cg04731861 chr2:219085781 ARPC2 -0.32 -6.8 -0.35 4.96e-11 Colorectal cancer; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg11570791 chr11:118186701 CD3E 0.4 6.38 0.33 5.88e-10 Intelligence (multi-trait analysis); CRC cis rs9811920 0.809 rs13059754 chr3:99678490 C/A cg07805332 chr3:99536008 MIR548G;C3orf26 0.38 5.85 0.31 1.18e-8 Axial length; CRC cis rs727505 1.000 rs10240673 chr7:124513050 A/G cg23710748 chr7:124431027 NA -0.8 -14.18 -0.62 6.24e-36 Lewy body disease; CRC cis rs9902453 0.765 rs12601647 chr17:28164953 C/G cg26525008 chr17:28256777 EFCAB5;SSH2 0.71 11.93 0.55 1.69e-27 Coffee consumption (cups per day); CRC cis rs28830936 1.000 rs17677199 chr15:41954613 C/G cg17847044 chr15:42102381 MAPKBP1 -0.3 -6.38 -0.33 5.95e-10 Diastolic blood pressure; CRC cis rs12451471 0.559 rs34746710 chr17:78079224 G/A cg12326244 chr17:78078995 GAA -0.38 -5.77 -0.3 1.87e-8 Plateletcrit;Mean corpuscular hemoglobin concentration; CRC trans rs6076960 0.684 rs6054055 chr20:6257517 C/G cg21095983 chr6:86352623 SYNCRIP 0.57 8.18 0.41 6.12e-15 Smooth-surface caries; CRC cis rs1953600 1.000 rs1953600 chr10:81911725 A/G cg04850286 chr10:81895943 PLAC9 0.38 6.83 0.35 4.16e-11 Sarcoidosis; CRC cis rs1030877 0.515 rs2679893 chr2:105909554 A/G cg02079111 chr2:105885981 TGFBRAP1 0.51 7.13 0.37 6.47e-12 Obesity-related traits; CRC cis rs4713118 0.824 rs13211701 chr6:27750079 T/C cg25164649 chr6:28176230 NA 0.6 7.91 0.4 3.87e-14 Parkinson's disease; CRC cis rs9858542 0.953 rs71324979 chr3:49619651 T/C cg03060546 chr3:49711283 APEH -0.49 -6.68 -0.35 9.97e-11 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs2243480 1.000 rs36033484 chr7:65390558 T/G cg12463550 chr7:65579703 CRCP 0.67 6.41 0.33 5.16e-10 Diabetic kidney disease; CRC cis rs868943 0.743 rs13213124 chr6:116335637 A/G cg05304507 chr6:116381966 FRK 0.29 6.5 0.34 2.98e-10 Total cholesterol levels; CRC cis rs734999 0.545 rs10910111 chr1:2542653 A/G cg20673091 chr1:2541236 MMEL1 0.38 6.12 0.32 2.66e-9 Ulcerative colitis; CRC cis rs6921919 0.697 rs6942030 chr6:28315958 A/T cg21251018 chr6:28226885 NKAPL 0.49 7.78 0.39 9.18e-14 Autism spectrum disorder or schizophrenia; CRC cis rs17152411 1.000 rs11245451 chr10:126661428 C/T cg07906193 chr10:126599966 NA 0.58 5.68 0.3 3e-8 Height; CRC cis rs9916302 0.904 rs8077104 chr17:37530510 A/G cg07936489 chr17:37558343 FBXL20 0.85 13.55 0.6 1.57e-33 Glomerular filtration rate (creatinine); CRC cis rs6502050 0.835 rs12450189 chr17:80095128 A/C cg25804541 chr17:80189381 SLC16A3 -0.31 -5.97 -0.31 6.08e-9 Life satisfaction; CRC cis rs2797160 0.967 rs1578793 chr6:126015057 A/G cg05901451 chr6:126070800 HEY2 0.39 6.06 0.32 3.66e-9 Endometrial cancer; CRC cis rs7086627 0.515 rs10887900 chr10:82210265 A/G cg09626299 chr10:82213104 TSPAN14 -0.35 -5.91 -0.31 8.69e-9 Post bronchodilator FEV1; CRC cis rs10540 1.000 rs61876332 chr11:487101 C/T cg03352830 chr11:487213 PTDSS2 0.65 7.33 0.37 1.83e-12 Body mass index; CRC cis rs9291683 0.585 rs12648479 chr4:10104571 G/A cg00071950 chr4:10020882 SLC2A9 -0.51 -8.99 -0.44 2.04e-17 Bone mineral density; CRC cis rs9368481 0.554 rs2754603 chr6:26965139 T/C cg18278486 chr6:26987575 LOC100270746;C6orf41 -0.48 -7.59 -0.39 3.23e-13 Autism spectrum disorder or schizophrenia; CRC cis rs2228479 0.850 rs1800355 chr16:89813194 C/T cg19635926 chr16:89946313 TCF25 0.66 5.97 0.31 6.1e-9 Skin colour saturation; CRC cis rs116095464 0.558 rs7710005 chr5:233572 A/G cg22496380 chr5:211416 CCDC127 -0.9 -10.32 -0.49 8.19e-22 Breast cancer; CRC trans rs459571 0.959 rs465724 chr9:136910097 C/T cg09836344 chr4:1243392 C4orf42;CTBP1 -0.77 -11.29 -0.53 3.21e-25 Platelet distribution width; CRC cis rs7208859 0.673 rs216418 chr17:28936537 G/A cg13385521 chr17:29058706 SUZ12P 0.48 6.09 0.32 3.17e-9 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs3768617 0.565 rs4652775 chr1:183061825 A/T ch.1.3577855R chr1:183094577 LAMC1 0.84 14.39 0.62 9.24e-37 Fuchs's corneal dystrophy; CRC cis rs713587 0.967 rs10182181 chr2:25150296 C/T cg22495460 chr2:25135724 ADCY3 0.78 14.36 0.62 1.2e-36 Body mass index in non-asthmatics; CRC cis rs6809651 0.524 rs6444106 chr3:185811495 C/T cg00760338 chr3:185826511 ETV5 -0.71 -8.94 -0.44 2.89e-17 Body mass index in physically active individuals;Glomerular filtration rate (creatinine);Body mass index (joint analysis main effects and physical activity interaction);Body mass index;Body mass index in physically inactive individuals; CRC cis rs10208712 0.525 rs56014028 chr2:4053971 A/G cg00217080 chr2:4050767 NA -0.26 -6.43 -0.33 4.58e-10 Restless legs syndrome; CRC cis rs896854 0.846 rs2340584 chr8:95916811 A/G cg13393036 chr8:95962371 TP53INP1 -0.5 -8.2 -0.41 5.6e-15 Type 2 diabetes; CRC cis rs4481887 0.504 rs7550630 chr1:248362311 C/T cg00666640 chr1:248458726 OR2T12 0.44 7.07 0.36 9.39e-12 Common traits (Other); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg13579901 chr1:167905492 DCAF6;BRP44 0.44 6.28 0.33 1.05e-9 Intelligence (multi-trait analysis); CRC cis rs10540 1.000 rs117339389 chr11:505025 T/A cg03352830 chr11:487213 PTDSS2 0.72 8.26 0.41 3.59e-15 Body mass index; CRC cis rs727505 1.000 rs10265763 chr7:124451514 G/A cg14311320 chr7:124405732 GPR37 -0.38 -5.65 -0.3 3.56e-8 Lewy body disease; CRC cis rs2486012 1.000 rs3011227 chr1:44325409 G/A cg12908607 chr1:44402522 ARTN -0.42 -6.04 -0.32 4.2e-9 Intelligence (multi-trait analysis); CRC cis rs11249608 0.548 rs2047354 chr5:178455247 T/C cg01312482 chr5:178451176 ZNF879 -0.36 -5.99 -0.31 5.53e-9 Pubertal anthropometrics; CRC cis rs11098499 0.908 rs11098527 chr4:120399906 A/G cg24375607 chr4:120327624 NA 0.48 7.45 0.38 8.14e-13 Corneal astigmatism; CRC cis rs2617583 0.679 rs2652511 chr5:1446389 A/G cg07151155 chr5:1473589 LPCAT1 -0.4 -6.28 -0.33 1.06e-9 Breast cancer; CRC cis rs2380220 0.576 rs4368819 chr6:96031109 T/G cg07718321 chr6:96025334 MANEA 0.57 7.31 0.37 2.09e-12 Behavioural disinhibition (generation interaction); CRC cis rs7917772 0.503 rs7100753 chr10:104300979 C/T cg22532475 chr10:104410764 TRIM8 -0.36 -6.8 -0.35 5.08e-11 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC cis rs7615952 0.599 rs67566088 chr3:125768973 C/A cg04553112 chr3:125709451 NA -0.51 -5.94 -0.31 7.11e-9 Blood pressure (smoking interaction); CRC cis rs9660180 0.935 rs2180311 chr1:1748734 T/C cg03396347 chr1:1875803 NA -0.6 -9.34 -0.46 1.53e-18 Body mass index; CRC cis rs10883723 0.810 rs10748824 chr10:104274466 T/C cg22532475 chr10:104410764 TRIM8 -0.36 -6.79 -0.35 5.39e-11 Allergic disease (asthma, hay fever or eczema); CRC cis rs3785574 1.000 rs3785574 chr17:61763185 T/C cg11494091 chr17:61959527 GH2 0.37 5.61 0.3 4.39e-8 Height; CRC cis rs13088645 0.541 rs9842113 chr3:134192338 G/A cg06109529 chr3:134205091 CEP63;ANAPC13 -0.5 -7.41 -0.38 1.07e-12 Coronary artery disease; CRC cis rs2739330 0.791 rs4822458 chr22:24265659 C/T cg23131131 chr22:24373011 LOC391322 -0.6 -9.17 -0.45 5.16e-18 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs6502050 0.698 rs36043222 chr17:80117822 G/T cg22110888 chr17:80059540 CCDC57 0.4 6.45 0.34 3.95e-10 Life satisfaction; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg27281285 chr12:120315368 CIT 0.44 6.14 0.32 2.32e-9 Response to antipsychotic treatment; CRC cis rs6502050 0.635 rs11867440 chr17:80147185 A/T cg09264619 chr17:80180166 NA -0.37 -6.17 -0.32 2.04e-9 Life satisfaction; CRC cis rs2404602 0.575 rs11072611 chr15:76947983 A/G cg03037974 chr15:76606532 NA 0.43 6.1 0.32 2.97e-9 Blood metabolite levels; CRC cis rs2976388 0.590 rs4736322 chr8:143822208 T/C cg15511327 chr8:143859410 LYNX1 -0.39 -6.51 -0.34 2.88e-10 Urinary tract infection frequency; CRC trans rs459571 0.959 rs408307 chr9:136892523 A/G cg09836344 chr4:1243392 C4orf42;CTBP1 0.74 10.24 0.49 1.48e-21 Platelet distribution width; CRC cis rs6968419 0.708 rs57321537 chr7:115883453 T/G cg02561103 chr7:115862891 TES -0.42 -6.31 -0.33 8.76e-10 Intraocular pressure; CRC cis rs35146811 0.735 rs2528900 chr7:99805319 A/G cg00553149 chr7:99775558 STAG3;GPC2 -0.24 -5.9 -0.31 8.81e-9 Coronary artery disease; CRC cis rs9318086 0.712 rs3794339 chr13:24434065 A/C cg25267304 chr13:24462978 PCOTH;MIPEP 0.62 10.03 0.48 7.55e-21 Myopia (pathological); CRC cis rs3096299 0.582 rs12935119 chr16:89542874 A/T cg00750074 chr16:89608354 SPG7 -0.52 -8.26 -0.41 3.63e-15 Multiple myeloma (IgH translocation); CRC cis rs4713118 0.621 rs4713133 chr6:28034041 T/C cg03623178 chr6:28175578 NA 0.89 11.83 0.55 3.94e-27 Parkinson's disease; CRC cis rs8141529 0.509 rs5762853 chr22:29245231 T/G cg02153584 chr22:29168773 CCDC117 0.51 7.07 0.36 9.51e-12 Lymphocyte counts; CRC cis rs6088580 0.634 rs1205334 chr20:32930369 T/C cg08999081 chr20:33150536 PIGU -0.62 -11.47 -0.53 7.85e-26 Glomerular filtration rate (creatinine); CRC cis rs11229555 0.598 rs4519112 chr11:58176386 C/T cg15696309 chr11:58395628 NA -0.8 -10.3 -0.49 9.5e-22 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; CRC trans rs9467711 1.000 rs9467713 chr6:26338128 T/C cg15845792 chr6:28175446 NA 0.67 6.72 0.35 8.17e-11 Autism spectrum disorder or schizophrenia; CRC cis rs796364 0.806 rs203766 chr2:200902672 T/C cg25936922 chr2:200820526 C2orf60;C2orf47 -0.68 -6.67 -0.34 1.11e-10 Schizophrenia; CRC cis rs780096 0.506 rs1262430 chr2:27673798 T/C cg17158414 chr2:27665306 KRTCAP3 -0.31 -6.69 -0.35 9.36e-11 Total body bone mineral density; CRC cis rs9308731 0.644 rs1837367 chr2:111874551 G/A cg04202892 chr2:111875749 ACOXL 0.41 6.63 0.34 1.37e-10 Chronic lymphocytic leukemia; CRC cis rs12410462 0.792 rs994666 chr1:227651454 C/T cg04117972 chr1:227635322 NA -0.52 -5.99 -0.31 5.61e-9 Major depressive disorder; CRC cis rs2635047 0.837 rs2571009 chr18:44650279 A/G cg23996704 chr18:44553084 KATNAL2 -0.3 -6.1 -0.32 2.96e-9 Educational attainment; CRC cis rs12325245 0.536 rs12931051 chr16:58626534 C/T cg26666090 chr16:58549219 SETD6 0.94 6.49 0.34 3.19e-10 Schizophrenia; CRC cis rs2050392 0.624 rs303449 chr10:30726845 G/A cg25182066 chr10:30743637 MAP3K8 -0.46 -6.09 -0.32 3.14e-9 Inflammatory bowel disease; CRC cis rs6582630 0.502 rs11522899 chr12:38270637 T/C cg13010199 chr12:38710504 ALG10B 0.45 5.75 0.3 2.07e-8 Drug-induced liver injury (flucloxacillin); CRC cis rs4713118 0.662 rs149901 chr6:27965503 C/T cg20615401 chr6:28092323 ZSCAN16 0.44 5.77 0.3 1.82e-8 Parkinson's disease; CRC cis rs7762018 1.000 rs17860606 chr6:170099561 G/A cg17545662 chr6:170176663 C6orf70 0.54 6.05 0.32 3.89e-9 Thiazide-induced adverse metabolic effects in hypertensive patients; CRC cis rs4713118 0.824 rs2179095 chr6:27750858 A/G cg20933634 chr6:27740509 NA -0.66 -9.43 -0.46 7.85e-19 Parkinson's disease; CRC cis rs7044106 0.791 rs10984997 chr9:123481206 T/A cg14255062 chr9:123606675 PSMD5;LOC253039 0.45 6.56 0.34 2.1e-10 Hip circumference adjusted for BMI; CRC cis rs4595586 0.546 rs10876163 chr12:39244915 G/A cg26384229 chr12:38710491 ALG10B 0.54 6.65 0.34 1.23e-10 Morning vs. evening chronotype; CRC cis rs2836974 0.831 rs6517521 chr21:40551588 A/G cg06238570 chr21:40685208 BRWD1 0.78 10.76 0.51 2.51e-23 Cognitive function; CRC cis rs8044995 0.563 rs56331745 chr16:68368770 G/T cg05110241 chr16:68378359 PRMT7 -0.76 -7.76 -0.39 1.06e-13 Schizophrenia; CRC cis rs11032090 1 rs11032090 chr11:4417129 A/G cg09983885 chr11:4415245 TRIM21 0.56 8.05 0.41 1.52e-14 Lung cancer; CRC cis rs3733585 0.605 rs7656624 chr4:10121097 T/C cg11266682 chr4:10021025 SLC2A9 -0.51 -9.6 -0.47 2.06e-19 Cleft plate (environmental tobacco smoke interaction); CRC cis rs294883 0.739 rs1504257 chr6:159727806 G/A cg14500486 chr6:159655392 FNDC1 -0.37 -6.2 -0.32 1.69e-9 Coronary artery disease; CRC cis rs67311347 1.000 rs6801185 chr3:40505060 C/T cg09455208 chr3:40491958 NA -0.45 -9.15 -0.45 6.27e-18 Renal cell carcinoma; CRC cis rs2730245 0.527 rs842700 chr7:158697565 G/A cg24397884 chr7:158709396 WDR60 0.89 10.95 0.52 5.29e-24 Height; CRC cis rs61008539 0.815 rs6960062 chr7:884665 A/G cg00475322 chr7:917719 C7orf20 0.45 8.09 0.41 1.15e-14 Perceived unattractiveness to mosquitoes; CRC cis rs4282054 0.631 rs13081155 chr3:52732429 A/G cg10802521 chr3:52805072 NEK4 -0.5 -7.77 -0.39 1.04e-13 Cognitive function; CRC cis rs3751196 0.901 rs57173983 chr12:104207870 T/G cg02344784 chr12:104178138 NT5DC3 0.7 7.12 0.37 6.87e-12 Sense of smell; CRC cis rs734999 0.588 rs6701238 chr1:2520500 G/A cg18854424 chr1:2615690 NA 0.48 9.43 0.46 7.53e-19 Ulcerative colitis; CRC cis rs13144136 0.710 rs10516208 chr4:10661734 C/T cg10242279 chr4:10666415 CLNK 0.38 6.6 0.34 1.6e-10 Resistance to antihypertensive treatment in hypertension; CRC cis rs12477438 0.748 rs6712773 chr2:99585781 A/G cg26064155 chr2:99771622 LIPT1;TSGA10 -0.79 -11.26 -0.53 4.44e-25 Chronic sinus infection; CRC cis rs10504229 1.000 rs61998259 chr8:58192290 T/C cg05313129 chr8:58192883 C8orf71 -0.47 -6.99 -0.36 1.49e-11 Developmental language disorder (linguistic errors); CRC cis rs10208940 0.920 rs7576303 chr2:68838019 G/A cg12452813 chr2:68675892 NA 0.48 5.93 0.31 7.66e-9 Urate levels in lean individuals; CRC cis rs7259376 0.936 rs7255829 chr19:22537311 C/T cg02657401 chr19:22469223 NA -0.33 -7.45 -0.38 8.05e-13 Menopause (age at onset); CRC trans rs1814175 0.616 rs1722020 chr11:49904189 G/A cg11707556 chr5:10655725 ANKRD33B -0.53 -10.19 -0.49 2.21e-21 Height; CRC cis rs7660520 0.524 rs6839881 chr4:183729137 A/T cg03209412 chr4:183728196 NA 0.51 6.03 0.32 4.31e-9 Pediatric autoimmune diseases; CRC cis rs798554 0.836 rs798502 chr7:2789880 G/T cg14895029 chr7:2775587 GNA12 0.45 6.8 0.35 4.92e-11 Height; CRC cis rs514406 0.861 rs503296 chr1:53283088 A/G cg08859206 chr1:53392774 SCP2 0.45 6.94 0.36 2.08e-11 Monocyte count; CRC cis rs9469578 1.000 rs73743326 chr6:33709980 C/A cg18708504 chr6:33715942 IP6K3 0.62 7.13 0.37 6.35e-12 Phosphorus levels; CRC trans rs61931739 0.534 rs11052959 chr12:33997095 T/C cg26384229 chr12:38710491 ALG10B 0.52 6.53 0.34 2.52e-10 Morning vs. evening chronotype; CRC cis rs11190604 1.000 rs2495745 chr10:102329075 A/G cg07080220 chr10:102295463 HIF1AN 0.45 5.69 0.3 2.84e-8 Palmitoleic acid (16:1n-7) levels; CRC cis rs1816752 1.000 rs7988810 chr13:25019096 T/C cg02811702 chr13:24901961 NA 0.48 6.54 0.34 2.33e-10 Obesity-related traits; CRC cis rs3796619 1.000 rs3796619 chr4:1095281 A/G cg27284194 chr4:1044797 NA 0.41 6.39 0.33 5.78e-10 Recombination rate (males); CRC cis rs2019137 0.560 rs7578633 chr2:113978650 C/T cg01577475 chr2:114033581 PAX8;LOC440839 -0.26 -6.53 -0.34 2.46e-10 Lymphocyte counts; CRC trans rs7618501 0.601 rs2624825 chr3:50154989 G/A cg21665057 chr3:196295764 WDR53;FBXO45 -0.58 -9.3 -0.46 1.98e-18 Intelligence (multi-trait analysis); CRC cis rs6502050 0.736 rs12150322 chr17:80061582 T/G cg25804541 chr17:80189381 SLC16A3 0.32 5.98 0.31 5.75e-9 Life satisfaction; CRC cis rs7945718 0.967 rs7930077 chr11:12778769 C/T cg25843174 chr11:12811716 TEAD1 0.49 9.35 0.46 1.43e-18 Educational attainment (years of education); CRC cis rs801193 0.569 rs10950050 chr7:66239588 A/C cg11764359 chr7:65958608 NA 0.55 8.48 0.42 7.72e-16 Aortic root size; CRC cis rs11009175 0.556 rs1418540 chr10:33297667 C/T cg00146027 chr10:33299147 NA -0.28 -6.47 -0.34 3.48e-10 Depression (quantitative trait); CRC trans rs11098499 0.645 rs72676059 chr4:120290828 C/G cg25214090 chr10:38739885 LOC399744 0.61 9.66 0.47 1.39e-19 Corneal astigmatism; CRC cis rs1223397 0.651 rs2496140 chr6:13309895 A/T cg20827128 chr6:13274284 PHACTR1 0.39 6.04 0.32 4.1e-9 Blood pressure; CRC trans rs1814175 0.645 rs10742953 chr11:49807491 C/G cg11707556 chr5:10655725 ANKRD33B 0.52 9.6 0.47 2.18e-19 Height; CRC trans rs12699921 0.632 rs2691601 chr7:17875431 C/T cg15753394 chr6:17282781 RBM24 -0.38 -6.38 -0.33 6.02e-10 Fibrinogen levels; CRC trans rs4346635 0.528 rs6534967 chr4:81412879 A/T cg13904968 chr20:56136012 PCK1 -0.19 -6.03 -0.32 4.42e-9 Colonoscopy-negative controls vs population controls; CRC cis rs6570726 0.791 rs4335004 chr6:145904764 G/A cg13319975 chr6:146136371 FBXO30 -0.43 -6.27 -0.33 1.13e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs11792861 0.926 rs72607174 chr9:111899132 A/T cg05043794 chr9:111880884 C9orf5 -0.35 -6.39 -0.33 5.71e-10 Menarche (age at onset); CRC cis rs6504622 0.905 rs3809854 chr17:45029294 T/C cg16759221 chr17:45003025 GOSR2 -0.54 -8.5 -0.42 6.64e-16 Orofacial clefts; CRC cis rs7493 0.806 rs17876090 chr7:95053404 A/T cg17330251 chr7:94953956 PON1 -0.61 -7.63 -0.39 2.5e-13 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs931127 0.747 rs11820062 chr11:65429936 T/C cg27068330 chr11:65405492 SIPA1 -0.49 -6.7 -0.35 8.8e-11 Systemic lupus erythematosus; CRC cis rs17767392 0.846 rs56180634 chr14:71989933 C/T cg13720639 chr14:72061746 SIPA1L1 -0.46 -6.1 -0.32 3.04e-9 Mitral valve prolapse; CRC cis rs6860806 0.531 rs2631359 chr5:131707892 C/T cg27615366 chr5:131592974 PDLIM4 -0.33 -5.81 -0.31 1.47e-8 Breast cancer; CRC cis rs7923609 1.000 rs10761723 chr10:64955581 C/T cg08743896 chr10:65200160 JMJD1C -0.39 -5.68 -0.3 2.93e-8 Educational attainment;Liver enzyme levels (alkaline phosphatase); CRC cis rs2076222 1.000 rs2076349 chr1:209800230 C/T cg00257659 chr1:209800214 LAMB3 -1.09 -10.61 -0.5 8.0700000000000006e-23 Fentanyl consumption in laparoscopic-assisted colectomy (first 24 hours); CRC cis rs7113874 0.589 rs10840058 chr11:8498399 G/T cg17679104 chr11:8615758 STK33 0.35 5.74 0.3 2.17e-8 Body mass index in physically active individuals;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs3018066 0.867 rs4600995 chr4:107049801 A/G cg01869342 chr4:106983673 TBCK 0.37 5.77 0.3 1.81e-8 Cancer; CRC cis rs6964587 0.621 rs39744 chr7:92043016 A/G cg17063962 chr7:91808500 NA 0.5 7.5 0.38 5.83e-13 Breast cancer; CRC cis rs11098499 0.955 rs4145951 chr4:120155817 A/G cg09307838 chr4:120376055 NA 0.63 9.72 0.47 8.33e-20 Corneal astigmatism; CRC cis rs875971 0.545 rs73376401 chr7:65639828 G/A cg05627663 chr7:65219948 SNORA22;CCT6P1 0.6 7.96 0.4 2.85e-14 Aortic root size; CRC trans rs9929218 0.861 rs4783667 chr16:68752878 C/A cg04657470 chr2:198365150 HSPE1;HSPD1 -0.97 -14.33 -0.62 1.56e-36 Colorectal cancer; CRC cis rs875971 0.964 rs697969 chr7:65558478 C/A cg00343986 chr7:65444356 GUSB -0.47 -6.92 -0.36 2.32e-11 Aortic root size; CRC cis rs981844 0.714 rs2405204 chr4:154705248 A/G cg10279832 chr4:154682576 RNF175 0.37 5.66 0.3 3.37e-8 Response to statins (LDL cholesterol change); CRC cis rs1023500 0.573 rs133374 chr22:42465941 G/A cg04733989 chr22:42467013 NAGA 0.57 8.69 0.43 1.71e-16 Schizophrenia; CRC cis rs868943 0.743 rs1890425 chr6:116339295 T/C cg15226275 chr6:116381976 FRK 0.31 7.36 0.38 1.45e-12 Total cholesterol levels; CRC cis rs9527 0.637 rs7096169 chr10:104618695 A/G cg15744005 chr10:104629667 AS3MT -0.4 -8.13 -0.41 8.75e-15 Arsenic metabolism; CRC cis rs11148252 0.846 rs4886077 chr13:52998697 G/T cg12458913 chr13:53173898 NA 0.52 8.02 0.4 1.88e-14 Lewy body disease; CRC cis rs941873 0.868 rs1483733 chr10:81130036 A/G cg09469691 chr10:81107165 PPIF 0.46 7.23 0.37 3.5e-12 Height; CRC cis rs7737355 0.947 rs11242081 chr5:130908135 T/C cg06307176 chr5:131281290 NA 0.43 6.14 0.32 2.41e-9 Life satisfaction; CRC cis rs6502050 0.835 rs8073351 chr17:80127625 A/G cg02741985 chr17:80059408 CCDC57 0.44 7.24 0.37 3.25e-12 Life satisfaction; CRC cis rs72781680 0.611 rs55868657 chr2:24295385 G/A cg20701182 chr2:24300061 SF3B14 0.62 7.39 0.38 1.26e-12 Lymphocyte counts; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg09851460 chr1:212964733 NSL1;TATDN3 0.5 6.87 0.35 3.3e-11 Response to antipsychotic treatment; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg00226754 chr12:124068984 TMED2 -0.42 -6.03 -0.32 4.32e-9 Myopia (pathological); CRC cis rs9467711 0.606 rs9379855 chr6:26364930 C/T cg12315302 chr6:26189340 HIST1H4D -0.69 -5.69 -0.3 2.75e-8 Autism spectrum disorder or schizophrenia; CRC cis rs1511802 0.501 rs7661323 chr4:187115996 T/G cg24794857 chr4:187113578 CYP4V2 0.41 5.84 0.31 1.28e-8 Blood protein levels; CRC cis rs2635047 0.967 rs2684843 chr18:44726260 T/A cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.44 7.2 0.37 4.22e-12 Educational attainment; CRC cis rs6502050 0.764 rs35713597 chr17:80119016 C/G cg25804541 chr17:80189381 SLC16A3 -0.31 -5.95 -0.31 6.84e-9 Life satisfaction; CRC cis rs10504229 0.728 rs72650858 chr8:58152832 G/A cg24829409 chr8:58192753 C8orf71 -0.58 -7.96 -0.4 2.86e-14 Developmental language disorder (linguistic errors); CRC cis rs6952808 0.609 rs12699449 chr7:1951227 G/C cg21782813 chr7:2030301 MAD1L1 0.39 7.17 0.37 4.83e-12 Bipolar disorder and schizophrenia; CRC cis rs875971 0.862 rs10950043 chr7:65988610 T/C cg11764359 chr7:65958608 NA 0.59 8.81 0.44 7.57e-17 Aortic root size; CRC cis rs1862618 0.853 rs832584 chr5:56179212 A/G cg03609598 chr5:56110824 MAP3K1 0.77 9.89 0.48 2.3e-20 Initial pursuit acceleration; CRC cis rs4867766 0.871 rs11747479 chr5:173955389 C/T cg20434911 chr5:173954559 NA -0.8 -9.17 -0.45 5.48e-18 Stroke; CRC cis rs3806843 0.766 rs2530239 chr5:140062547 C/T cg19875535 chr5:140030758 IK -0.54 -8.74 -0.43 1.19e-16 Depressive symptoms (multi-trait analysis); CRC cis rs853679 0.517 rs55747925 chr6:28044337 T/C cg12963246 chr6:28129442 ZNF389 0.47 5.61 0.3 4.26e-8 Depression; CRC cis rs9914988 0.537 rs28448745 chr17:27188296 A/C cg16670446 chr17:27188758 MIR451;MIR144 -0.56 -8.75 -0.43 1.11e-16 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC trans rs7615952 0.546 rs2979333 chr3:125360343 T/A cg21747405 chr11:67723411 NA -0.49 -6.36 -0.33 6.71e-10 Blood pressure (smoking interaction); CRC cis rs4237845 0.537 rs4237844 chr12:58267987 A/G cg00677455 chr12:58241039 CTDSP2 -0.83 -11.99 -0.55 1.01e-27 Intelligence (multi-trait analysis); CRC cis rs9517320 0.935 rs9645891 chr13:99126800 A/G cg20487152 chr13:99095054 FARP1 0.36 5.97 0.31 6.23e-9 Longevity; CRC cis rs1568889 1.000 rs7937117 chr11:28370038 C/G cg06544937 chr11:28130018 METT5D1;KIF18A 0.79 11.36 0.53 1.83e-25 Bipolar disorder; CRC cis rs763014 0.932 rs34498660 chr16:666149 A/G cg08989290 chr16:615782 NHLRC4 0.49 9.7 0.47 9.67e-20 Height; CRC trans rs3858526 0.959 rs61876223 chr11:5943393 G/A cg01505111 chr6:125621795 HDDC2 0.39 6.18 0.32 1.9e-9 DNA methylation (variation); CRC cis rs7633770 0.841 rs6442010 chr3:46669500 A/T cg11219411 chr3:46661640 NA 0.74 12.99 0.58 2.02e-31 Coronary artery disease; CRC cis rs2213920 0.522 rs7847118 chr9:118199763 T/C cg13918206 chr9:118159781 DEC1 0.62 5.96 0.31 6.67e-9 Docetaxel-induced peripheral neuropathy in metastatic castrate-resistant prostate cancer; CRC cis rs1267303 0.675 rs7519040 chr1:46986641 A/G cg25110126 chr1:46999211 NA 0.55 8.31 0.42 2.52e-15 Monobrow; CRC cis rs4731207 0.596 rs1383751 chr7:124579721 A/T cg23710748 chr7:124431027 NA -0.39 -6.12 -0.32 2.71e-9 Cutaneous malignant melanoma; CRC cis rs6762 0.748 rs1130663 chr11:837582 G/A cg16425592 chr11:842748 TSPAN4;POLR2L -0.55 -8.23 -0.41 4.59e-15 Mean platelet volume; CRC cis rs28386778 0.897 rs6504185 chr17:61848792 A/G cg23090583 chr17:61904693 PSMC5;FTSJ3 1.05 20.23 0.74 1.07e-59 Prudent dietary pattern; CRC cis rs651907 0.557 rs13077925 chr3:101488181 T/A cg12386194 chr3:101231763 SENP7 0.5 7.3 0.37 2.2e-12 Colorectal cancer; CRC cis rs67311347 0.544 rs6769627 chr3:40327845 G/A cg09455208 chr3:40491958 NA 0.32 6.43 0.33 4.4e-10 Renal cell carcinoma; CRC cis rs3733585 0.699 rs12498150 chr4:9950537 C/T cg00071950 chr4:10020882 SLC2A9 -0.55 -9.75 -0.47 6.85e-20 Cleft plate (environmental tobacco smoke interaction); CRC cis rs2836950 0.501 rs4818018 chr21:40694072 C/T cg17971929 chr21:40555470 PSMG1 -0.51 -7.26 -0.37 2.73e-12 Menarche (age at onset); CRC cis rs780096 0.526 rs704795 chr2:27716494 G/A cg12000995 chr2:27665139 KRTCAP3 -0.3 -6.29 -0.33 1e-9 Total body bone mineral density; CRC cis rs854765 0.583 rs2350977 chr17:17802779 A/G cg16928487 chr17:17741425 SREBF1 -0.55 -9.93 -0.48 1.67e-20 Total body bone mineral density; CRC cis rs3736485 0.966 rs11070859 chr15:51890802 C/G cg08986416 chr15:51914746 DMXL2 -0.45 -6.46 -0.34 3.79e-10 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs4713118 0.629 rs172165 chr6:28020814 T/G cg02683197 chr6:28174875 NA 0.73 9.78 0.47 5.29e-20 Parkinson's disease; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg13903809 chr12:93964785 SOCS2 0.46 6.36 0.33 6.63e-10 Anxiety disorder; CRC cis rs9522267 0.502 rs9522297 chr13:112234419 C/T cg26182253 chr13:112236782 NA 0.31 6.3 0.33 9.74e-10 Hepatitis; CRC cis rs17209837 0.607 rs45553044 chr7:87085613 A/G cg00919237 chr7:87102261 ABCB4 -0.54 -7.09 -0.36 8.37e-12 Gallbladder cancer; CRC cis rs6693567 0.507 rs863862 chr1:150352361 T/A cg15654264 chr1:150340011 RPRD2 0.42 6.4 0.33 5.48e-10 Migraine; CRC cis rs9916302 0.904 rs755500 chr17:37409865 C/T cg07936489 chr17:37558343 FBXL20 -0.81 -12.29 -0.56 7.94e-29 Glomerular filtration rate (creatinine); CRC cis rs6952808 0.792 rs4421257 chr7:1955152 T/C cg21782813 chr7:2030301 MAD1L1 0.42 7.45 0.38 8.23e-13 Bipolar disorder and schizophrenia; CRC cis rs7909074 0.714 rs10900129 chr10:45398609 G/C cg04218760 chr10:45406644 TMEM72 -0.29 -7.42 -0.38 1.04e-12 Mean corpuscular volume; CRC cis rs362272 0.502 rs2857839 chr4:3036630 T/C cg22930642 chr4:2936657 C4orf10;MFSD10 -0.4 -5.73 -0.3 2.21e-8 Serum sulfate level; CRC cis rs3733585 0.673 rs7378340 chr4:9955198 C/T cg11266682 chr4:10021025 SLC2A9 -0.46 -9.37 -0.46 1.18e-18 Cleft plate (environmental tobacco smoke interaction); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg08779779 chr2:200322566 SATB2 0.37 6.16 0.32 2.18e-9 Liver disease severity in Alagille syndrome; CRC cis rs3733346 0.520 rs62297086 chr4:909040 G/A cg08222618 chr4:941054 TMEM175 0.75 15.01 0.64 3.63e-39 Sjögren's syndrome; CRC trans rs1455244 0.700 rs7229302 chr18:11508904 G/T cg15056687 chr19:44079628 XRCC1 0.39 6.09 0.32 3.11e-9 Schizophrenia; CRC cis rs2425143 0.908 rs12480111 chr20:34423186 G/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.53 -5.98 -0.31 5.95e-9 Blood protein levels; CRC cis rs2576037 0.526 rs10853545 chr18:44475220 A/T cg07643061 chr18:44555308 TCEB3C;TCEB3CL;KATNAL2 -0.33 -5.85 -0.31 1.21e-8 Personality dimensions; CRC cis rs62244186 0.545 rs725866 chr3:44765533 A/G cg10263370 chr3:44754102 ZNF502 -0.38 -6.46 -0.34 3.73e-10 Depressive symptoms; CRC cis rs9858542 0.953 rs6779524 chr3:49450449 C/T cg03060546 chr3:49711283 APEH -0.48 -6.78 -0.35 5.57e-11 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC trans rs1814175 0.647 rs2903409 chr11:49953612 C/G cg15704280 chr7:45808275 SEPT13 -0.74 -12.09 -0.55 4.36e-28 Height; CRC cis rs4919694 1.000 rs10509760 chr10:104634107 A/G cg04362960 chr10:104952993 NT5C2 1.09 9.93 0.48 1.68e-20 Arsenic metabolism; CRC cis rs6951245 0.872 rs75493422 chr7:1072890 C/T cg22907277 chr7:1156413 C7orf50 0.71 7.33 0.37 1.85e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs912057 0.965 rs1294409 chr6:6738355 A/G cg06612196 chr6:6737390 NA -0.55 -8.95 -0.44 2.57e-17 Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction); CRC cis rs6951245 0.554 rs78999139 chr7:1138525 G/A cg18297960 chr7:1142765 C7orf50 -0.44 -6.12 -0.32 2.61e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs853679 0.546 rs175597 chr6:27810626 T/C cg03623178 chr6:28175578 NA 0.77 6.61 0.34 1.51e-10 Depression; CRC cis rs10503871 0.545 rs13253760 chr8:30503792 C/T cg26383811 chr8:30366931 RBPMS -0.42 -5.96 -0.31 6.46e-9 Metabolite levels (X-11787); CRC cis rs4713118 0.824 rs2092075 chr6:27749330 G/C cg15845792 chr6:28175446 NA 0.68 8.92 0.44 3.35e-17 Parkinson's disease; CRC cis rs12762955 0.507 rs10737004 chr10:1039019 T/C cg20503657 chr10:835505 NA -0.48 -6.68 -0.35 1.03e-10 Response to angiotensin II receptor blocker therapy; CRC cis rs9733 0.596 rs72702536 chr1:150662574 C/T cg18016565 chr1:150552671 MCL1 0.46 6.68 0.35 1.04e-10 Tonsillectomy; CRC cis rs10504229 0.683 rs66893068 chr8:58144238 A/G cg04204079 chr8:58130323 NA -0.45 -5.81 -0.3 1.5e-8 Developmental language disorder (linguistic errors); CRC cis rs9297145 0.585 rs10953281 chr7:98772131 C/T cg05967295 chr7:98741636 SMURF1 -0.66 -10.63 -0.51 6.86e-23 Crohn's disease;Inflammatory bowel disease;Ulcerative colitis; CRC cis rs8067545 0.750 rs28637614 chr17:19985108 G/T cg13482628 chr17:19912719 NA 0.47 7.53 0.38 4.96e-13 Schizophrenia; CRC cis rs4713118 0.513 rs149972 chr6:27983227 C/T cg15786705 chr6:28176104 NA 0.61 8.73 0.43 1.35e-16 Parkinson's disease; CRC trans rs2303319 0.504 rs1023835 chr2:162593973 A/G cg10498984 chr16:28874827 SH2B1 -0.73 -6.3 -0.33 9.75e-10 Cognitive function; CRC cis rs5417 0.662 rs8067500 chr17:7172631 A/G cg14660024 chr17:7154518 C17orf81;DULLARD -0.69 -11.35 -0.53 2.07e-25 Diastolic blood pressure; CRC cis rs8180040 0.676 rs66564457 chr3:47020072 G/A cg02527881 chr3:46936655 PTH1R -0.42 -7.82 -0.4 7.38e-14 Colorectal cancer; CRC trans rs6600671 0.934 rs12060031 chr1:121243450 A/G cg09829573 chr1:144692074 NBPF9 0.43 6.54 0.34 2.36e-10 Hip geometry; CRC cis rs55788414 0.932 rs9940186 chr16:81182199 A/T cg06400318 chr16:81190750 PKD1L2 -0.6 -6.88 -0.35 3.02e-11 Left ventricular obstructive tract defect (maternal effect); CRC cis rs2976388 1.000 rs10216533 chr8:143763690 G/A cg04969067 chr8:143858791 LYNX1 -0.35 -5.93 -0.31 7.87e-9 Urinary tract infection frequency; CRC cis rs9527 0.637 rs7096169 chr10:104618695 A/G cg08772003 chr10:104629869 AS3MT -0.39 -6.63 -0.34 1.38e-10 Arsenic metabolism; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg02825653 chr17:7383046 ZBTB4 0.44 7.06 0.36 9.71e-12 Liver disease severity in Alagille syndrome; CRC cis rs8180040 0.691 rs12489211 chr3:47221451 T/A cg27129171 chr3:47204927 SETD2 0.68 11.14 0.52 1.13e-24 Colorectal cancer; CRC cis rs524281 0.773 rs2155030 chr11:66030687 A/G cg16950941 chr11:66035639 RAB1B -0.72 -8.16 -0.41 7.42e-15 Electroencephalogram traits; CRC cis rs4563143 0.514 rs55727361 chr19:29300415 A/T cg03161606 chr19:29218774 NA 0.54 6.26 0.33 1.21e-9 Methadone dose in opioid dependence; CRC cis rs9826463 0.582 rs73238186 chr3:142141180 A/C cg20824294 chr3:142316082 PLS1 0.38 6.03 0.32 4.36e-9 QRS duration in Tripanosoma cruzi seropositivity; CRC cis rs7647973 0.925 rs9834003 chr3:49216472 T/C cg20833759 chr3:49053208 WDR6;DALRD3 0.54 8.23 0.41 4.57e-15 Menarche (age at onset); CRC cis rs2742417 0.967 rs6800556 chr3:45752229 G/T cg04837898 chr3:45731254 SACM1L -0.36 -5.97 -0.31 6.18e-9 Response to anti-depressant treatment in major depressive disorder; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg24087403 chr10:71078535 HK1 0.38 6.06 0.32 3.72e-9 Liver disease severity in Alagille syndrome; CRC cis rs7209460 0.518 rs9894634 chr17:1967501 C/T cg15816464 chr17:2026533 SMG6 0.33 5.98 0.31 5.72e-9 Coronary artery disease;Total body bone mineral density; CRC cis rs4713118 0.869 rs2056925 chr6:27690905 A/G cg12273811 chr6:28175739 NA 0.54 7.72 0.39 1.42e-13 Parkinson's disease; CRC cis rs6502050 0.799 rs4482345 chr17:80152919 G/A cg02741985 chr17:80059408 CCDC57 0.44 7.29 0.37 2.3e-12 Life satisfaction; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg05892773 chr1:112282121 C1orf183 0.45 6.36 0.33 6.94e-10 Intelligence (multi-trait analysis); CRC cis rs2115630 1.000 rs4633690 chr15:85361960 C/T cg09876464 chr15:85330779 ZNF592 0.48 8.28 0.42 3.21e-15 P wave terminal force; CRC cis rs7208859 0.623 rs12006 chr17:29110652 G/A cg13385521 chr17:29058706 SUZ12P 0.73 8.33 0.42 2.14e-15 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs10924970 0.613 rs12027933 chr1:235440411 A/T cg09010748 chr1:235293032 TOMM20 -0.41 -5.72 -0.3 2.42e-8 Asthma; CRC trans rs1005277 0.540 rs2224248 chr10:38451886 A/G cg17830980 chr10:43048298 ZNF37B -0.59 -9.89 -0.48 2.25e-20 Extrinsic epigenetic age acceleration; CRC cis rs9325144 0.600 rs7312522 chr12:38730423 A/G cg13010199 chr12:38710504 ALG10B 0.4 5.95 0.31 6.77e-9 Morning vs. evening chronotype; CRC cis rs4253772 0.591 rs6519994 chr22:46656805 A/G cg24881330 chr22:46731750 TRMU -0.57 -6.84 -0.35 3.98e-11 LDL cholesterol;Cholesterol, total; CRC cis rs9303280 0.936 rs907091 chr17:37921742 A/G cg00129232 chr17:37814104 STARD3 -0.43 -6.69 -0.35 9.35e-11 Self-reported allergy; CRC cis rs6963495 0.818 rs711430 chr7:105167969 A/G cg19920283 chr7:105172520 RINT1 0.54 6.58 0.34 1.81e-10 Bipolar disorder (body mass index interaction); CRC cis rs12410462 1.000 rs6672162 chr1:227632335 G/A cg04117972 chr1:227635322 NA 0.7 7.84 0.4 6.22e-14 Major depressive disorder; CRC cis rs208520 0.954 rs1468153 chr6:67009054 A/C cg07460842 chr6:66804631 NA 0.86 10.35 0.5 6.48e-22 Exhaled nitric oxide output; CRC cis rs10751667 0.666 rs11246358 chr11:967349 G/A cg23136738 chr11:925521 AP2A2 -0.4 -6.57 -0.34 1.96e-10 Alzheimer's disease (late onset); CRC trans rs6500957 0.920 rs17648524 chr16:7459683 C/G cg11455018 chr16:30709778 SRCAP 0.4 6.01 0.31 4.97e-9 Spherical equivalent (joint analysis main effects and education interaction); CRC trans rs2303319 0.504 rs62189048 chr2:162613494 G/C cg22922770 chr7:98923339 ARPC1A -0.67 -5.98 -0.31 5.68e-9 Cognitive function; CRC cis rs929354 0.772 rs6954050 chr7:156978554 A/G cg05182265 chr7:156933206 UBE3C -0.76 -14.52 -0.62 3.01e-37 Body mass index; CRC cis rs367615 0.552 rs2963025 chr5:108733256 A/C cg17395555 chr5:108820864 NA -0.34 -6.68 -0.35 1.04e-10 Colorectal cancer (SNP x SNP interaction); CRC cis rs654950 0.776 rs2759254 chr1:42035683 G/C cg06885757 chr1:42089581 HIVEP3 -0.53 -8.86 -0.44 5.09e-17 Airway imaging phenotypes; CRC cis rs1799949 1.000 rs11653460 chr17:41331306 C/T cg01879757 chr17:41196368 BRCA1 -0.44 -6.69 -0.35 9.45e-11 Menopause (age at onset); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg18679886 chr7:107531975 DLD 0.43 6.06 0.32 3.81e-9 Intelligence (multi-trait analysis); CRC cis rs11212617 1.000 rs7112136 chr11:108287131 G/A cg01991180 chr11:108092276 ATM;NPAT 0.42 6.34 0.33 7.39e-10 Response to metformin in type 2 diabetes (glycemic); CRC cis rs11249608 0.548 rs10479520 chr5:178451447 C/A cg01312482 chr5:178451176 ZNF879 -0.35 -5.87 -0.31 1.06e-8 Pubertal anthropometrics; CRC cis rs11711311 0.955 rs9860642 chr3:113419211 G/A cg15478005 chr3:113465772 ATP6V1A;NAA50 0.48 6.57 0.34 1.97e-10 IgG glycosylation; CRC cis rs4689388 0.926 rs4689394 chr4:6291003 C/G cg25554036 chr4:6271136 WFS1 -0.54 -8.84 -0.44 5.71e-17 Type 2 diabetes and other traits;Type 2 diabetes; CRC cis rs853679 0.517 rs17711344 chr6:28077602 A/G cg21251018 chr6:28226885 NKAPL -0.48 -6.21 -0.32 1.64e-9 Depression; CRC cis rs9487051 0.735 rs419106 chr6:109520067 C/G cg21918786 chr6:109611834 NA -0.35 -6.06 -0.32 3.7e-9 Reticulocyte fraction of red cells; CRC cis rs1355223 0.583 rs1396881 chr11:34870506 G/T cg24088639 chr11:34937564 PDHX;APIP -0.58 -8.52 -0.43 5.73e-16 Systemic lupus erythematosus and Systemic sclerosis; CRC cis rs1799949 1.000 rs4793191 chr17:41204377 A/G cg25072359 chr17:41440525 NA 0.45 6.82 0.35 4.26e-11 Menopause (age at onset); CRC cis rs7647973 0.961 rs4955443 chr3:49286618 T/G cg20833759 chr3:49053208 WDR6;DALRD3 0.53 8.13 0.41 8.68e-15 Menarche (age at onset); CRC cis rs1401999 1.000 rs939337 chr3:183701147 G/C cg20387954 chr3:183756860 HTR3D 0.46 7.77 0.39 1.04e-13 Anterior chamber depth; CRC cis rs6951245 1.000 rs77305932 chr7:1100861 T/A cg22907277 chr7:1156413 C7orf50 0.73 7.68 0.39 1.78e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs4654899 0.965 rs2873424 chr1:21500701 C/A cg02927042 chr1:21476669 EIF4G3 -0.45 -7.22 -0.37 3.56e-12 Superior frontal gyrus grey matter volume; CRC cis rs7412746 0.611 rs10788794 chr1:150728676 T/C cg10589385 chr1:150898437 SETDB1 0.3 6.23 0.33 1.39e-9 Melanoma; CRC cis rs9674544 0.757 rs11871214 chr17:47124902 G/T cg10950924 chr17:47092072 IGF2BP1 -0.35 -5.79 -0.3 1.67e-8 Primary tooth development (time to first tooth eruption);Primary tooth development (number of teeth); CRC cis rs9292777 0.901 rs7730591 chr5:40423280 G/A cg09067459 chr5:40385259 NA 0.53 9.13 0.45 7.24e-18 Crohn's disease;Multiple sclerosis; CRC cis rs2637266 0.561 rs10824440 chr10:78489079 C/T cg18941641 chr10:78392320 NA -0.36 -6.11 -0.32 2.8e-9 Pulmonary function; CRC cis rs6951245 1.000 rs76214082 chr7:1102097 T/A cg26224354 chr7:1096374 C7orf50;GPR146 -0.93 -12.05 -0.55 5.9e-28 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs7666738 0.830 rs6848404 chr4:98946750 A/G cg05340658 chr4:99064831 C4orf37 0.61 9.54 0.47 3.45e-19 Colonoscopy-negative controls vs population controls; CRC cis rs117623576 0.590 rs2988084 chr10:32398653 C/T cg03047570 chr10:32398778 NA 0.43 5.92 0.31 7.89e-9 Anti-saccade response; CRC cis rs4988958 0.565 rs3755265 chr2:103052816 C/A cg03938978 chr2:103052716 IL18RAP 0.59 10.33 0.49 7.63e-22 Asthma (childhood onset); CRC cis rs7107174 0.892 rs11601195 chr11:78073501 A/G cg02023728 chr11:77925099 USP35 0.49 7.47 0.38 7.48e-13 Testicular germ cell tumor; CRC cis rs7258465 0.931 rs8107351 chr19:18612758 G/A cg01065977 chr19:18549689 ISYNA1 -0.41 -6.41 -0.33 5.1e-10 Breast cancer; CRC cis rs77633900 0.772 rs284898 chr15:76750695 A/G cg21673338 chr15:77095150 SCAPER -0.73 -6.45 -0.34 3.94e-10 Non-glioblastoma glioma;Glioma; CRC cis rs875971 0.965 rs6971509 chr7:65714970 G/T cg12463550 chr7:65579703 CRCP -0.5 -7.18 -0.37 4.56e-12 Aortic root size; CRC cis rs898097 0.783 rs11650335 chr17:80835111 A/G cg15369054 chr17:80825471 TBCD 0.54 8.81 0.44 7.1e-17 Breast cancer; CRC cis rs9660180 0.837 rs915292 chr1:1792157 A/C cg23982607 chr1:1823379 GNB1 -0.91 -16.66 -0.68 1.33e-45 Body mass index; CRC cis rs8014204 0.816 rs11159107 chr14:75341266 C/A cg08847533 chr14:75593920 NEK9 -0.4 -5.91 -0.31 8.46e-9 Caffeine consumption; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg25130390 chr15:65810150 DPP8 -0.41 -6.22 -0.32 1.52e-9 Myopia (pathological); CRC trans rs10982213 0.830 rs2274163 chr9:117188714 C/T cg01246254 chr10:124134882 PLEKHA1 0.46 7.15 0.37 5.56e-12 Interleukin-6 levels; CRC cis rs2075371 0.933 rs2544181 chr7:133944934 C/T cg20476274 chr7:133979776 SLC35B4 0.74 12.81 0.58 9.33e-31 Mean platelet volume; CRC cis rs477895 0.629 rs7130030 chr11:63933733 T/G cg23719950 chr11:63933701 MACROD1 -0.66 -8.51 -0.42 6.22e-16 Mean platelet volume; CRC trans rs11722228 1.000 rs11722228 chr4:9915741 C/T cg26043149 chr18:55253948 FECH 0.68 9.93 0.48 1.67e-20 Gout;Urate levels;Serum uric acid levels; CRC cis rs6696846 0.765 rs2836 chr1:205111761 G/T cg03948781 chr1:205179583 DSTYK -0.41 -5.83 -0.31 1.34e-8 Red blood cell count; CRC cis rs155076 1.000 rs2783107 chr13:21837532 C/A cg21970626 chr13:21893289 NA 0.45 5.91 0.31 8.56e-9 White matter hyperintensity burden; CRC trans rs2898857 0.545 rs12602382 chr17:47356805 C/A cg11430096 chr6:110968061 CDK19 0.51 7.8 0.4 8.44e-14 Cancer; CRC cis rs4481887 1.000 rs4593862 chr1:248480176 G/T cg13385794 chr1:248469461 NA 0.4 6.87 0.35 3.23e-11 Common traits (Other); CRC cis rs10504229 0.683 rs17194792 chr8:58107195 A/C cg11062466 chr8:58055876 NA 0.61 7.3 0.37 2.21e-12 Developmental language disorder (linguistic errors); CRC cis rs780096 0.527 rs59644396 chr2:27646083 A/G cg12648201 chr2:27665141 KRTCAP3 -0.31 -6.11 -0.32 2.88e-9 Total body bone mineral density; CRC cis rs2281845 0.533 rs10753891 chr1:201100482 A/G cg01987224 chr1:201084466 NA 0.37 5.71 0.3 2.57e-8 Permanent tooth development; CRC trans rs80033912 0.713 rs7629936 chr3:49836707 G/A cg21659725 chr3:3221576 CRBN 0.55 7.0 0.36 1.45e-11 Intelligence (multi-trait analysis); CRC cis rs9372498 0.536 rs9489442 chr6:118885950 A/C cg24463073 chr6:118973353 C6orf204 0.52 6.91 0.36 2.52e-11 Diastolic blood pressure; CRC cis rs9303401 0.659 rs7225896 chr17:56637337 T/C cg02118635 chr17:56770003 RAD51C;TEX14 0.81 9.7 0.47 9.7e-20 Cognitive test performance; CRC cis rs6066835 1.000 rs6125446 chr20:47348161 C/G cg18078177 chr20:47281410 PREX1 0.65 5.78 0.3 1.78e-8 Multiple myeloma; CRC cis rs514406 0.584 rs11205997 chr1:53195271 G/C cg25767906 chr1:53392781 SCP2 0.43 6.72 0.35 7.95e-11 Monocyte count; CRC cis rs7119 0.717 rs35268067 chr15:77753688 C/G cg05673287 chr15:77411982 SGK269 -0.54 -8.18 -0.41 6.41e-15 Type 2 diabetes; CRC cis rs7772486 0.875 rs2777482 chr6:146320341 A/C cg23711669 chr6:146136114 FBXO30 0.53 8.42 0.42 1.17e-15 Lobe attachment (rater-scored or self-reported); CRC cis rs589448 0.902 rs315131 chr12:69761839 T/G cg20891283 chr12:69753455 YEATS4 0.98 21.22 0.76 1.46e-63 Cerebrospinal fluid biomarker levels; CRC cis rs4423214 0.840 rs1790339 chr11:71182761 C/A cg13043300 chr11:71146211 DHCR7 -0.44 -5.98 -0.31 5.98e-9 Vitamin D levels; CRC cis rs10751667 0.643 rs6597969 chr11:928843 C/T cg01483505 chr11:975446 AP2A2 0.43 6.87 0.35 3.26e-11 Alzheimer's disease (late onset); CRC cis rs9733 0.566 rs72702554 chr1:150678234 A/G cg15448220 chr1:150897856 SETDB1 0.44 6.27 0.33 1.12e-9 Tonsillectomy; CRC cis rs335206 1.000 rs335206 chr5:122504566 T/C cg16368670 chr5:122501738 PRDM6 -0.29 -5.65 -0.3 3.39e-8 QRS duration; CRC cis rs10791323 0.559 rs10750548 chr11:133729469 A/G cg15485101 chr11:133734466 NA 0.47 7.91 0.4 3.89e-14 Childhood ear infection; CRC cis rs7258465 0.965 rs2561043 chr19:18622683 A/T cg01065977 chr19:18549689 ISYNA1 -0.39 -6.0 -0.31 5.15e-9 Breast cancer; CRC cis rs2077654 0.822 rs4148627 chr11:17436271 G/A cg25308976 chr11:17434268 ABCC8 0.8 8.09 0.41 1.14e-14 Gout; CRC cis rs10971721 0.731 rs12377117 chr9:33806584 A/G cg13495928 chr9:33750294 PRSS3 0.56 5.82 0.31 1.38e-8 Body mass index; CRC cis rs4713118 0.614 rs9468209 chr6:27694421 C/T cg06470822 chr6:28175283 NA 0.59 8.61 0.43 3.17e-16 Parkinson's disease; CRC cis rs6546324 0.625 rs980227 chr2:67864258 T/G cg15745817 chr2:67799979 NA -0.56 -9.78 -0.47 5.28e-20 Endometriosis; CRC cis rs597539 0.652 rs513615 chr11:68705504 G/T cg04772025 chr11:68637568 NA 0.48 7.21 0.37 3.86e-12 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs7659604 0.605 rs1507994 chr4:122749541 C/T cg06713675 chr4:122721982 EXOSC9 -0.41 -6.85 -0.35 3.64e-11 Type 2 diabetes; CRC cis rs4481887 0.927 rs7534188 chr1:248434303 C/T cg13385794 chr1:248469461 NA -0.39 -7.0 -0.36 1.42e-11 Common traits (Other); CRC trans rs3733585 0.605 rs4697710 chr4:10122649 T/C cg26043149 chr18:55253948 FECH -0.51 -7.11 -0.36 7.46e-12 Cleft plate (environmental tobacco smoke interaction); CRC trans rs11098499 0.909 rs2127821 chr4:120394535 T/C cg25214090 chr10:38739885 LOC399744 0.66 10.67 0.51 5.22e-23 Corneal astigmatism; CRC cis rs727505 0.564 rs57841320 chr7:124847732 T/A cg23710748 chr7:124431027 NA -0.62 -10.33 -0.49 7.81e-22 Lewy body disease; CRC cis rs2153535 0.606 rs11243253 chr6:8380193 T/C cg21535247 chr6:8435926 SLC35B3 -0.42 -6.18 -0.32 1.89e-9 Motion sickness; CRC cis rs6738485 0.588 rs12712247 chr2:106849382 C/T cg16099169 chr2:106886729 NA -0.36 -6.35 -0.33 6.97e-10 Pursuit maintenance gain;Pursuit maintenance gain in psychotic disorders; CRC trans rs7615952 0.800 rs12489350 chr3:125644116 T/C cg21747405 chr11:67723411 NA -0.43 -6.13 -0.32 2.48e-9 Blood pressure (smoking interaction); CRC cis rs13118159 0.778 rs12640984 chr4:1338834 G/A cg19318889 chr4:1322082 MAEA 0.39 5.78 0.3 1.76e-8 Longevity; CRC cis rs908922 0.676 rs11581947 chr1:152482587 G/A cg23254163 chr1:152506842 NA 0.43 8.73 0.43 1.33e-16 Hair morphology; CRC cis rs4665809 1.000 rs6739061 chr2:26256147 C/T cg26119090 chr2:26468346 HADHA;HADHB -0.61 -7.96 -0.4 2.87e-14 Gut microbiome composition (summer); CRC cis rs7618915 0.501 rs2289247 chr3:52727257 C/T cg05573699 chr3:52720067 GNL3;PBRM1 -0.48 -7.0 -0.36 1.43e-11 Bipolar disorder; CRC cis rs75422866 0.867 rs73104148 chr12:48090515 A/G cg14736327 chr12:48174669 SLC48A1 -0.79 -6.01 -0.31 4.92e-9 Pneumonia; CRC cis rs10504229 0.724 rs16922734 chr8:58111192 C/T cg24829409 chr8:58192753 C8orf71 -0.55 -7.9 -0.4 4.11e-14 Developmental language disorder (linguistic errors); CRC cis rs4237845 0.844 rs4630335 chr12:58302258 A/G cg02175503 chr12:58329896 NA 0.58 7.79 0.39 9.12e-14 Intelligence (multi-trait analysis); CRC cis rs28386778 0.799 rs2584612 chr17:61932204 A/G cg07362569 chr17:61921086 SMARCD2 0.36 5.6 0.3 4.41e-8 Prudent dietary pattern; CRC cis rs7833790 0.724 rs72603871 chr8:82754460 C/G cg27398817 chr8:82754497 SNX16 0.43 5.95 0.31 6.84e-9 Diastolic blood pressure; CRC cis rs7113874 0.524 rs10840092 chr11:8624915 A/G cg02811074 chr11:8615871 STK33 0.32 5.72 0.3 2.35e-8 Body mass index in physically active individuals;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs2882667 0.690 rs3804199 chr5:138162129 T/C cg09476006 chr5:138032270 NA -0.58 -10.51 -0.5 1.8e-22 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs4964805 0.580 rs1866292 chr12:104174192 C/T cg02344784 chr12:104178138 NT5DC3 0.55 8.12 0.41 9.52e-15 Attention deficit hyperactivity disorder; CRC cis rs34172651 0.517 rs7204288 chr16:24784531 A/G cg02428538 chr16:24856791 SLC5A11 -0.54 -6.17 -0.32 2.05e-9 Intelligence (multi-trait analysis); CRC cis rs9463078 0.691 rs17288278 chr6:45298482 G/A cg25276700 chr6:44698697 NA 0.25 6.11 0.32 2.89e-9 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; CRC cis rs6570726 0.967 rs439017 chr6:145806123 T/C cg05347473 chr6:146136440 FBXO30 0.39 6.24 0.33 1.34e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs172166 0.561 rs149973 chr6:27983613 G/T cg21251018 chr6:28226885 NKAPL 0.57 9.8 0.48 4.44e-20 Cardiac Troponin-T levels; CRC cis rs1997103 1.000 rs1997098 chr7:55405594 G/T cg17469321 chr7:55412551 NA 0.72 11.3 0.53 3.17e-25 QRS interval (sulfonylurea treatment interaction); CRC trans rs2303319 0.504 rs56260047 chr2:162497225 G/T cg27113153 chr11:123612418 ZNF202 -0.68 -6.06 -0.32 3.72e-9 Cognitive function; CRC cis rs941873 0.868 rs12780295 chr10:81115438 G/A cg09469691 chr10:81107165 PPIF 0.49 7.77 0.39 1.01e-13 Height; CRC cis rs1997103 1.000 rs6976824 chr7:55396115 A/C cg17469321 chr7:55412551 NA 0.64 9.43 0.46 7.47e-19 QRS interval (sulfonylurea treatment interaction); CRC cis rs1448094 0.511 rs61930581 chr12:86157241 G/A cg00310523 chr12:86230176 RASSF9 0.41 6.62 0.34 1.5e-10 Major depressive disorder; CRC trans rs916888 0.779 rs199528 chr17:44843136 C/T cg22433210 chr17:43662623 NA 1.03 10.45 0.5 2.99e-22 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs7927592 0.913 rs2236708 chr11:68378045 G/A cg16797656 chr11:68205561 LRP5 0.37 5.76 0.3 1.97e-8 Total body bone mineral density; CRC cis rs1129187 0.755 rs4714638 chr6:42917017 A/G cg05552183 chr6:42928497 GNMT 0.52 7.91 0.4 3.94e-14 Alzheimer's disease in APOE e4+ carriers; CRC cis rs11098499 0.954 rs11935596 chr4:120412457 G/C cg09307838 chr4:120376055 NA 0.7 10.94 0.52 5.58e-24 Corneal astigmatism; CRC cis rs3018066 0.836 rs9996093 chr4:107098543 T/C cg01869342 chr4:106983673 TBCK 0.37 5.71 0.3 2.48e-8 Cancer; CRC cis rs2153535 0.580 rs7341382 chr6:8470549 A/G cg21535247 chr6:8435926 SLC35B3 0.5 7.53 0.38 4.89e-13 Motion sickness; CRC cis rs1355223 0.902 rs1539250 chr11:34742775 C/T cg11058730 chr11:34937778 PDHX;APIP -0.4 -5.61 -0.3 4.22e-8 Systemic lupus erythematosus and Systemic sclerosis; CRC cis rs459571 0.920 rs2520094 chr9:136919985 A/T cg13789015 chr9:136890014 NCRNA00094 0.44 6.02 0.32 4.6e-9 Platelet distribution width; CRC trans rs2727020 0.658 rs7111215 chr11:49430552 T/C cg03929089 chr4:120376271 NA -0.87 -16.07 -0.66 2.67e-43 Coronary artery disease; CRC cis rs7945705 0.902 rs10743095 chr11:8936984 T/C cg00186954 chr11:8933980 ST5;C11orf17 0.45 7.13 0.37 6.35e-12 Hemoglobin concentration; CRC cis rs6570726 0.935 rs415590 chr6:145851244 T/C cg05347473 chr6:146136440 FBXO30 0.38 6.09 0.32 3.19e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs7618501 0.633 rs9861216 chr3:50059339 A/G cg24308560 chr3:49941425 MST1R 0.54 9.02 0.45 1.63e-17 Intelligence (multi-trait analysis); CRC cis rs6088813 0.857 rs1886692 chr20:33986549 C/T cg14752227 chr20:34000481 UQCC -0.38 -5.68 -0.3 2.91e-8 Height; CRC cis rs4665809 0.590 rs5001914 chr2:26415429 A/G cg04944784 chr2:26401820 FAM59B -0.84 -10.81 -0.51 1.64e-23 Gut microbiome composition (summer); CRC cis rs8067545 0.641 rs1638525 chr17:19848594 G/C cg04132472 chr17:19861366 AKAP10 0.46 7.15 0.37 5.64e-12 Schizophrenia; CRC cis rs9847710 0.670 rs36051354 chr3:52986012 T/C cg15147215 chr3:52552868 STAB1 0.41 5.64 0.3 3.59e-8 Ulcerative colitis; CRC cis rs16975963 0.843 rs11672163 chr19:38373856 G/A cg15135657 chr19:38346511 NA -0.42 -5.66 -0.3 3.26e-8 Longevity; CRC cis rs10503871 0.690 rs4147357 chr8:30344444 T/C cg26383811 chr8:30366931 RBPMS 0.49 7.91 0.4 3.91e-14 Metabolite levels (X-11787); CRC cis rs2576037 0.501 rs7227700 chr18:44537102 T/G cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.53 8.5 0.42 6.69e-16 Personality dimensions; CRC cis rs3741798 1.000 rs61922025 chr12:12486263 G/A cg08615371 chr12:12503544 MANSC1 0.98 8.33 0.42 2.16e-15 Cerebrospinal fluid biomarker levels; CRC cis rs17155006 0.664 rs387981 chr7:107741337 T/A cg05962710 chr7:107745446 LAMB4 -0.43 -7.57 -0.39 3.74e-13 Pneumococcal bacteremia; CRC cis rs861020 0.630 rs657861 chr1:210006884 C/G cg05527609 chr1:210001259 C1orf107 0.77 10.63 0.51 7.11e-23 Orofacial clefts; CRC cis rs6918586 0.658 rs198830 chr6:26118246 T/A cg18357526 chr6:26021779 HIST1H4A -0.48 -7.19 -0.37 4.38e-12 Schizophrenia; CRC cis rs2658782 0.789 rs2658773 chr11:93126914 A/G cg15737290 chr11:93063684 CCDC67 0.46 6.73 0.35 7.69e-11 Pulmonary function decline; CRC cis rs10256972 0.552 rs2949195 chr7:1202705 G/A cg18765753 chr7:1198926 ZFAND2A -0.42 -7.26 -0.37 2.81e-12 Longevity;Endometriosis; CRC cis rs60871478 0.679 rs4076965 chr7:793272 A/G cg05535760 chr7:792225 HEATR2 0.98 11.34 0.53 2.19e-25 Cerebrospinal P-tau181p levels; CRC trans rs7615952 0.546 rs2979306 chr3:125312130 C/A cg07211511 chr3:129823064 LOC729375 -0.53 -6.19 -0.32 1.83e-9 Blood pressure (smoking interaction); CRC cis rs6960043 0.936 rs62448618 chr7:15052211 T/A cg19272540 chr7:15055459 NA -0.22 -5.7 -0.3 2.6e-8 Type 2 diabetes; CRC cis rs58688157 0.705 rs12421646 chr11:578844 C/G cg16486109 chr11:613632 IRF7 0.7 11.44 0.53 9.66e-26 Systemic lupus erythematosus; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg12939425 chr5:130344188 NA -0.39 -6.25 -0.33 1.24e-9 Thyroid stimulating hormone; CRC trans rs783540 0.933 rs2567636 chr15:83263428 C/T cg18393722 chr15:85113863 UBE2QP1 -0.38 -6.43 -0.33 4.53e-10 Schizophrenia; CRC cis rs6503525 0.701 rs28618095 chr17:38109075 T/C cg26162295 chr17:38119207 GSDMA -0.34 -5.7 -0.3 2.63e-8 Asthma; CRC cis rs9388451 0.839 rs3966775 chr6:126067655 C/A cg05901451 chr6:126070800 HEY2 -0.67 -11.62 -0.54 2.26e-26 Brugada syndrome; CRC cis rs7945705 0.902 rs2568059 chr11:8884161 T/C cg21881798 chr11:8931708 C11orf17;ST5 -0.75 -12.86 -0.58 5.94e-31 Hemoglobin concentration; CRC cis rs11212617 0.967 rs4754305 chr11:108075912 T/C cg14761454 chr11:108092087 ATM;NPAT 0.42 6.36 0.33 6.56e-10 Response to metformin in type 2 diabetes (glycemic); CRC trans rs61883261 0.764 rs10833426 chr11:21008120 C/A cg13263472 chr14:102593156 HSP90AA1 -0.63 -6.15 -0.32 2.31e-9 Response to amphetamines; CRC cis rs501120 0.925 rs1657344 chr10:44781234 C/T cg09554077 chr10:44749378 NA 0.86 10.71 0.51 3.77e-23 Coronary artery disease;Coronary heart disease; CRC cis rs6089584 0.861 rs2180302 chr20:60576369 A/G cg06108461 chr20:60628389 TAF4 -0.71 -12.3 -0.56 7.51e-29 Body mass index; CRC cis rs2243480 0.901 rs57126451 chr7:65416306 T/C cg18252515 chr7:66147081 NA -1.07 -12.49 -0.57 1.49e-29 Diabetic kidney disease; CRC cis rs990171 0.955 rs3755268 chr2:103038527 C/G cg03938978 chr2:103052716 IL18RAP 0.46 5.78 0.3 1.69e-8 Lymphocyte counts; CRC cis rs9649213 0.613 rs6961129 chr7:97975542 T/G cg00277769 chr7:97922759 BAIAP2L1 -0.61 -10.66 -0.51 5.51e-23 Prostate cancer (SNP x SNP interaction); CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg00840926 chr19:58919549 ZNF584 0.48 6.22 0.32 1.54e-9 Thyroid stimulating hormone; CRC cis rs2692947 0.711 rs56791141 chr2:96587496 C/T cg23100626 chr2:96804247 ASTL 0.26 6.93 0.36 2.22e-11 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; CRC cis rs875971 0.964 rs60193905 chr7:65971260 A/G cg18876405 chr7:65276391 NA 0.51 8.75 0.43 1.12e-16 Aortic root size; CRC cis rs2120019 1.000 rs12910644 chr15:75358388 A/G cg11632617 chr15:75315747 PPCDC -0.53 -7.37 -0.38 1.35e-12 Blood trace element (Zn levels); CRC cis rs4665809 0.627 rs13032756 chr2:26489730 A/T cg25036284 chr2:26402008 FAM59B 0.65 8.55 0.43 4.61e-16 Gut microbiome composition (summer); CRC cis rs8031584 0.541 rs2959037 chr15:31218164 T/C cg08704250 chr15:31115839 NA 0.32 5.85 0.31 1.21e-8 Huntington's disease progression; CRC cis rs61160187 0.582 rs11739952 chr5:60275977 C/A cg16298547 chr5:60138761 ELOVL7 -0.27 -5.73 -0.3 2.26e-8 Educational attainment (years of education);Educational attainment (college completion); CRC cis rs6089584 0.925 rs35683654 chr20:60625401 G/T cg23262073 chr20:60523788 NA 0.55 8.23 0.41 4.57e-15 Body mass index; CRC cis rs9517320 0.534 rs912330 chr13:99131294 C/T cg07423050 chr13:99094983 FARP1 -0.54 -7.72 -0.39 1.39e-13 Longevity; CRC cis rs1878931 0.535 rs55732163 chr16:3411518 A/C cg02880119 chr16:3481970 NA 0.44 6.24 0.33 1.32e-9 Body mass index (adult); CRC cis rs9381040 0.674 rs3747742 chr6:41162518 C/T cg20398880 chr6:41068722 NFYA;LOC221442 0.39 5.98 0.31 5.76e-9 Alzheimer's disease (late onset); CRC cis rs55823223 0.648 rs936393 chr17:73847613 A/G cg10935138 chr17:73851978 WBP2 0.61 7.47 0.38 7.26e-13 Psoriasis; CRC trans rs13221576 0.569 rs35899033 chr7:93973120 G/A cg25582398 chr5:1217743 SLC6A19 0.55 6.14 0.32 2.34e-9 Intelligence; CRC cis rs311392 0.966 rs404354 chr8:55087196 A/G cg06042504 chr8:55087323 NA -0.42 -6.5 -0.34 2.97e-10 Pelvic organ prolapse (moderate/severe); CRC cis rs10791323 0.569 rs10750541 chr11:133713189 A/C cg15485101 chr11:133734466 NA -0.42 -6.95 -0.36 1.94e-11 Childhood ear infection; CRC cis rs4253772 0.551 rs9615936 chr22:46686328 C/G cg24881330 chr22:46731750 TRMU 0.62 6.54 0.34 2.39e-10 LDL cholesterol;Cholesterol, total; CRC cis rs877282 0.898 rs12356709 chr10:763365 A/G cg06581033 chr10:766294 NA -0.52 -5.78 -0.3 1.71e-8 Uric acid levels; CRC cis rs35110281 0.667 rs2250773 chr21:45087786 T/C cg04455712 chr21:45112962 RRP1B 0.42 8.24 0.41 4.15e-15 Mean corpuscular volume; CRC cis rs9611565 0.659 rs1569516 chr22:41910244 C/T cg06634786 chr22:41940651 POLR3H -0.72 -8.47 -0.42 8.34e-16 Vitiligo; CRC trans rs8002861 0.664 rs4941474 chr13:44450289 C/T cg12856521 chr11:46389249 DGKZ 0.44 7.09 0.36 8.28e-12 Leprosy; CRC cis rs72781680 0.665 rs2953028 chr2:24068126 T/C cg08917208 chr2:24149416 ATAD2B 0.57 6.93 0.36 2.18e-11 Lymphocyte counts; CRC cis rs6952808 0.573 rs12668848 chr7:2020995 G/A cg04267008 chr7:1944627 MAD1L1 -0.58 -8.34 -0.42 2.12e-15 Bipolar disorder and schizophrenia; CRC cis rs4889855 0.530 rs9914854 chr17:78598662 A/G cg16591659 chr17:78472290 NA -0.43 -6.23 -0.32 1.42e-9 Fractional excretion of uric acid; CRC cis rs8031584 0.697 rs798080 chr15:31122169 T/C cg08704250 chr15:31115839 NA 0.54 9.81 0.48 4.43e-20 Huntington's disease progression; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg26187342 chr17:65713858 NOL11 -0.46 -6.75 -0.35 6.5500000000000006e-11 Myopia (pathological); CRC cis rs9487051 0.872 rs9374079 chr6:109609619 A/G cg12927641 chr6:109611667 NA -0.38 -6.97 -0.36 1.78e-11 Reticulocyte fraction of red cells; CRC cis rs904251 0.861 rs1757180 chr6:37486145 T/C cg25019722 chr6:37503610 NA -0.47 -8.67 -0.43 2.05e-16 Cognitive performance; CRC cis rs2242116 1.000 rs2168443 chr3:46947087 A/T cg02527881 chr3:46936655 PTH1R 0.5 9.27 0.46 2.53e-18 Birth weight; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg17017335 chr3:97540665 NA 0.41 6.04 0.32 4.13e-9 Intelligence (multi-trait analysis); CRC cis rs4819052 1.000 rs13052356 chr21:46663588 G/A cg02159808 chr21:46707872 POFUT2;LOC642852 0.62 7.67 0.39 2.02e-13 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs7618915 0.798 rs353547 chr3:52268866 A/G cg15147215 chr3:52552868 STAB1 0.59 9.14 0.45 6.45e-18 Bipolar disorder; CRC cis rs798554 0.757 rs2533882 chr7:2846894 G/T cg13628971 chr7:2884303 GNA12 0.56 7.54 0.38 4.56e-13 Height; CRC trans rs1499614 1.000 rs2707828 chr7:66171377 G/A cg10756647 chr7:56101905 PSPH 0.77 8.1 0.41 1.09e-14 Gout; CRC cis rs11608355 1.000 rs7132057 chr12:109880279 A/C cg19025524 chr12:109796872 NA -0.48 -6.88 -0.35 2.94e-11 Neuroticism; CRC trans rs6833159 0.527 rs10939231 chr4:28829372 A/T cg13000219 chr12:21590632 PYROXD1 -0.44 -6.68 -0.35 1.03e-10 Underweight status; CRC cis rs12477438 1.000 rs11897712 chr2:99735697 G/A cg14399236 chr2:99771627 LIPT1;TSGA10 -0.7 -8.57 -0.43 4.12e-16 Chronic sinus infection; CRC cis rs853679 0.517 rs3823180 chr6:28061744 G/A cg06470822 chr6:28175283 NA 1.0 13.31 0.59 1.27e-32 Depression; CRC cis rs7131987 0.903 rs11050162 chr12:29420054 T/G cg09582351 chr12:29534625 ERGIC2 -0.33 -7.08 -0.36 9.04e-12 QT interval; CRC trans rs11825064 0.606 rs2000858 chr11:134485458 A/G cg00033773 chr19:12779366 MORG1;C19orf56 0.45 6.17 0.32 1.97e-9 Seasonality; CRC cis rs2115630 0.905 rs1975277 chr15:85329558 C/T cg17507749 chr15:85114479 UBE2QP1 -0.38 -5.7 -0.3 2.61e-8 P wave terminal force; CRC cis rs9457247 0.967 rs376097 chr6:167410878 A/G cg23791538 chr6:167370224 RNASET2 -0.39 -6.08 -0.32 3.37e-9 Crohn's disease; CRC cis rs35110281 0.805 rs2838330 chr21:45023876 T/A cg01579765 chr21:45077557 HSF2BP -0.37 -7.06 -0.36 9.84e-12 Mean corpuscular volume; CRC cis rs8013055 0.796 rs8005568 chr14:105971794 A/G cg23356831 chr14:105996513 TMEM121 0.39 6.78 0.35 5.59e-11 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis); CRC cis rs9457247 1.000 rs430097 chr6:167405073 A/G cg23791538 chr6:167370224 RNASET2 -0.38 -5.94 -0.31 7.32e-9 Crohn's disease; CRC cis rs6860806 0.507 rs635619 chr5:131720265 G/A cg18301423 chr5:131593218 PDLIM4 -0.39 -6.56 -0.34 2.14e-10 Breast cancer; CRC cis rs11166629 1.000 rs1036820 chr8:135646571 C/T cg27224718 chr8:135614730 ZFAT -0.52 -7.74 -0.39 1.26e-13 Smoking quantity; CRC cis rs274567 0.501 rs274571 chr5:131712125 A/G cg09877947 chr5:131593287 PDLIM4 -0.44 -7.3 -0.37 2.13e-12 Blood metabolite levels; CRC cis rs1971762 0.545 rs3864905 chr12:54058324 C/T cg06632207 chr12:54070931 ATP5G2 0.49 8.61 0.43 3.04e-16 Height; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg14492347 chr15:85292323 ZNF592 0.48 6.18 0.32 1.92e-9 Thyroid stimulating hormone; CRC cis rs2050392 0.767 rs10763787 chr10:30700753 G/A cg25182066 chr10:30743637 MAP3K8 0.43 5.82 0.31 1.42e-8 Inflammatory bowel disease; CRC cis rs2991971 0.967 rs2275276 chr1:45973928 C/T cg24296786 chr1:45957014 TESK2 0.55 8.33 0.42 2.28e-15 High light scatter reticulocyte count; CRC cis rs67340775 0.541 rs200979 chr6:27852357 G/A cg06470822 chr6:28175283 NA 0.81 8.22 0.41 4.63e-15 Lung cancer in ever smokers; CRC cis rs6860806 0.507 rs2631364 chr5:131706914 C/G cg22638593 chr5:131593259 PDLIM4 -0.39 -6.44 -0.33 4.3e-10 Breast cancer; CRC trans rs9630182 0.561 rs10832042 chr11:13481424 T/C cg13741668 chr9:85679694 NA 0.37 5.97 0.31 6.12e-9 Bone mineral density; CRC cis rs780096 0.526 rs780117 chr2:27698343 C/G cg12000995 chr2:27665139 KRTCAP3 -0.32 -6.67 -0.35 1.1e-10 Total body bone mineral density; CRC cis rs2195987 1.000 rs2195987 chr19:24149545 A/G cg00460763 chr19:23944615 RPSAP58 -0.53 -5.9 -0.31 9.18e-9 Testicular germ cell tumor; CRC cis rs2949837 0.581 rs1117457 chr7:45970037 G/A cg23193639 chr7:45961078 IGFBP3 0.38 6.38 0.33 6.18e-10 Sitting height ratio; CRC cis rs7208859 0.673 rs73277964 chr17:29179201 A/T cg13385521 chr17:29058706 SUZ12P 0.65 7.73 0.39 1.31e-13 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs561341 1.000 rs68140514 chr17:30335781 T/C cg19193384 chr17:30244184 NA -0.55 -6.94 -0.36 2.07e-11 Hip circumference adjusted for BMI; CRC cis rs703842 0.532 rs238516 chr12:58117355 T/C cg15848620 chr12:58087721 OS9 -0.49 -6.65 -0.34 1.19e-10 Multiple sclerosis; CRC cis rs3741404 0.620 rs2236647 chr11:63964605 A/G cg05016508 chr11:63871570 FLRT1;MACROD1 -0.42 -6.52 -0.34 2.72e-10 Platelet count; CRC cis rs2180341 0.920 rs1073931 chr6:127681762 A/T cg27446573 chr6:127587934 RNF146 0.93 13.48 0.6 2.71e-33 Breast cancer; CRC cis rs7119 0.717 rs62009069 chr15:77817877 T/G cg10437265 chr15:77819839 NA 0.69 12.74 0.57 1.76e-30 Type 2 diabetes; CRC cis rs898097 0.625 rs898095 chr17:80890638 T/C cg19046167 chr17:80928561 B3GNTL1 0.44 7.46 0.38 7.74e-13 Breast cancer; CRC cis rs2153535 0.580 rs4960433 chr6:8523697 A/G cg07606381 chr6:8435919 SLC35B3 0.64 10.62 0.51 7.85e-23 Motion sickness; CRC cis rs6570726 0.935 rs368848 chr6:145855281 A/T cg23711669 chr6:146136114 FBXO30 0.7 12.42 0.57 2.56e-29 Lobe attachment (rater-scored or self-reported); CRC cis rs1552244 1.000 rs722509 chr3:10102377 T/A cg10729496 chr3:10149963 C3orf24 0.55 7.26 0.37 2.73e-12 Alzheimer's disease; CRC cis rs1046896 0.553 rs1044661 chr17:80901020 G/A cg16060761 chr17:80687452 NA -0.49 -6.48 -0.34 3.41e-10 Glycated hemoglobin levels; CRC cis rs56104184 0.723 rs73063524 chr19:49409004 T/C cg15549821 chr19:49342101 PLEKHA4 -0.51 -5.74 -0.3 2.13e-8 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; CRC cis rs804292 0.695 rs804279 chr8:11623889 A/T cg26752888 chr8:11627280 NEIL2 0.52 7.27 0.37 2.64e-12 Alcohol dependence;Nicotine use; CRC cis rs60843830 1.000 rs62114505 chr2:242426 A/G cg25945732 chr2:264204 ACP1;SH3YL1 0.73 12.02 0.55 7.68e-28 Spherical equivalent (joint analysis main effects and education interaction); CRC cis rs7666738 0.830 rs17548431 chr4:98923768 C/G cg05340658 chr4:99064831 C4orf37 0.6 9.35 0.46 1.41e-18 Colonoscopy-negative controls vs population controls; CRC cis rs2404602 0.684 rs10851888 chr15:76902506 C/T cg23625390 chr15:77176239 SCAPER -0.87 -13.3 -0.59 1.31e-32 Blood metabolite levels; CRC cis rs7216064 0.734 rs12942774 chr17:65967562 A/G cg12091567 chr17:66097778 LOC651250 0.58 7.91 0.4 4.02e-14 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CRC trans rs7618501 1.000 rs7648987 chr3:49868455 A/G cg21659725 chr3:3221576 CRBN 0.85 16.04 0.66 3.66e-43 Intelligence (multi-trait analysis); CRC cis rs9903692 0.954 rs11079808 chr17:46180232 A/G cg21215337 chr17:46176117 CBX1 -0.43 -7.95 -0.4 2.95e-14 Pulse pressure; CRC cis rs8177179 0.967 rs4994581 chr3:133437563 T/C cg17775713 chr3:133465469 TF 0.35 6.23 0.32 1.41e-9 Iron status biomarkers (transferrin levels); CRC cis rs763014 0.593 rs28455838 chr16:681966 T/C cg18653534 chr16:772142 FAM173A -0.36 -5.69 -0.3 2.77e-8 Height; CRC cis rs2011503 0.941 rs72999063 chr19:19380596 G/T cg11584989 chr19:19387371 SF4 0.54 6.54 0.34 2.34e-10 Bipolar disorder; CRC cis rs4936891 0.577 rs7945483 chr11:123903709 T/A cg22125253 chr11:123886957 OR10G4 -0.33 -5.79 -0.3 1.63e-8 Male fertility; CRC cis rs4713118 0.516 rs7739216 chr6:28079946 G/T cg15786705 chr6:28176104 NA 0.76 9.45 0.46 6.35e-19 Parkinson's disease; CRC cis rs12410462 0.901 rs79626242 chr1:227650385 A/G cg23173402 chr1:227635558 NA 0.71 8.08 0.41 1.27e-14 Major depressive disorder; CRC trans rs6446298 0.738 rs1060970 chr3:49708769 T/C cg21659725 chr3:3221576 CRBN -0.61 -7.25 -0.37 3.08e-12 Intelligence (multi-trait analysis); CRC trans rs2303319 0.504 rs56965753 chr2:162597251 A/G cg09481857 chr22:21368659 P2RX6;MGC16703 -0.65 -6.31 -0.33 9.13e-10 Cognitive function; CRC cis rs875971 0.545 rs67688847 chr7:65626051 G/A cg05627663 chr7:65219948 SNORA22;CCT6P1 0.6 7.73 0.39 1.29e-13 Aortic root size; CRC cis rs6867032 1.000 rs4975802 chr5:2019750 T/C cg26168224 chr5:2018326 NA 0.99 18.15 0.71 1.62e-51 Gut microbiome composition (winter); CRC cis rs4780401 0.632 rs7192366 chr16:11835209 C/G cg01061890 chr16:11836724 TXNDC11 -0.61 -8.94 -0.44 2.9e-17 Rheumatoid arthritis; CRC cis rs860295 0.812 rs11264413 chr1:155788656 G/A cg02153340 chr1:155202674 NA -0.52 -6.26 -0.33 1.18e-9 Body mass index; CRC cis rs9467160 0.871 rs9461014 chr6:24449008 T/G cg20631270 chr6:24437470 GPLD1 0.48 6.66 0.34 1.16e-10 Liver enzyme levels; CRC cis rs1005277 0.579 rs2474594 chr10:38426661 G/C cg25517755 chr10:38738941 LOC399744 -0.43 -6.25 -0.33 1.26e-9 Extrinsic epigenetic age acceleration; CRC cis rs11098499 0.820 rs13128602 chr4:120459366 C/T cg24375607 chr4:120327624 NA -0.48 -7.47 -0.38 7.05e-13 Corneal astigmatism; CRC cis rs4662945 0.525 rs10174479 chr2:130296287 A/C cg05903289 chr2:130345205 NA -0.37 -7.04 -0.36 1.1e-11 Response to cytidine analogues (gemcitabine); CRC trans rs475616 0.917 rs866919 chr10:30513283 C/T cg06700871 chr2:84686330 SUCLG1 0.48 7.02 0.36 1.25e-11 Monocyte count; CRC cis rs9322193 0.962 rs6899661 chr6:150139229 T/C cg05861140 chr6:150128134 PCMT1 -0.44 -7.05 -0.36 1.06e-11 Lung cancer; CRC cis rs9372498 0.505 rs9320655 chr6:118830981 T/C cg15382696 chr6:118971807 C6orf204 0.62 8.05 0.41 1.5e-14 Diastolic blood pressure; CRC trans rs10983614 1.000 rs7867776 chr9:120072627 A/G cg24296761 chr19:42408458 ARHGEF1 0.31 6.27 0.33 1.17e-9 Survival in pancreatic cancer; CRC cis rs17376456 0.877 rs13156865 chr5:93390908 C/A cg21475434 chr5:93447410 FAM172A 0.72 7.85 0.4 6.07e-14 Diabetic retinopathy; CRC cis rs6460942 0.915 rs62447640 chr7:12488282 A/T cg20607287 chr7:12443886 VWDE -0.66 -6.84 -0.35 3.78e-11 Coronary artery disease; CRC trans rs4276421 0.805 rs13354798 chr5:45457077 A/G cg04793272 chr11:119020941 ABCG4 -0.39 -6.39 -0.33 5.62e-10 P wave duration; CRC cis rs7705042 0.828 rs11750521 chr5:141500704 T/C cg08523384 chr5:141488047 NDFIP1 -0.34 -6.08 -0.32 3.29e-9 Asthma; CRC trans rs11098499 1.000 rs1011054 chr4:120202387 A/G cg25214090 chr10:38739885 LOC399744 -0.5 -7.32 -0.37 1.89e-12 Corneal astigmatism; CRC cis rs4654899 0.785 rs10916911 chr1:21290061 C/T cg02927042 chr1:21476669 EIF4G3 -0.39 -6.24 -0.33 1.31e-9 Superior frontal gyrus grey matter volume; CRC cis rs10489202 1.000 rs275157 chr1:168064178 T/C cg24449463 chr1:168025552 DCAF6 -0.5 -6.21 -0.32 1.64e-9 Schizophrenia; CRC cis rs897984 0.762 rs1870293 chr16:30970941 T/C cg02466173 chr16:30829666 NA 0.57 8.41 0.42 1.25e-15 Dementia with Lewy bodies; CRC cis rs911119 0.955 rs59059917 chr20:23595675 C/T cg16589663 chr20:23618590 CST3 0.57 7.26 0.37 2.89e-12 Chronic kidney disease; CRC cis rs1552244 1.000 rs61052895 chr3:10147516 G/A cg13047869 chr3:10149882 C3orf24 0.56 7.67 0.39 1.91e-13 Alzheimer's disease; CRC cis rs9435341 0.965 rs1335055 chr1:107624563 A/G cg09367891 chr1:107599246 PRMT6 0.62 9.67 0.47 1.23e-19 Facial morphology (factor 21, depth of nasal alae); CRC cis rs861020 0.630 rs599649 chr1:210003402 T/C cg05527609 chr1:210001259 C1orf107 0.78 10.7 0.51 3.83e-23 Orofacial clefts; CRC trans rs7267979 1.000 rs2259873 chr20:25280781 A/G cg17903999 chr18:56338584 MALT1 -0.42 -6.99 -0.36 1.52e-11 Liver enzyme levels (alkaline phosphatase); CRC cis rs807669 0.770 rs807458 chr22:19220648 G/T cg02655711 chr22:19163373 SLC25A1 0.53 8.45 0.42 9.29e-16 Metabolite levels; CRC cis rs1003719 0.715 rs2835646 chr21:38546574 G/A cg10648535 chr21:38446584 PIGP;TTC3 -0.48 -6.72 -0.35 7.91e-11 Eye color traits; CRC cis rs1448094 0.512 rs12313775 chr12:86241197 G/A cg25456477 chr12:86230367 RASSF9 0.32 5.67 0.3 3.13e-8 Major depressive disorder; CRC cis rs10540 1.000 rs61876342 chr11:496193 T/G cg03576123 chr11:487126 PTDSS2 -1.04 -10.79 -0.51 1.91e-23 Body mass index; CRC cis rs1552244 1.000 rs112847840 chr3:10101652 C/T cg02579736 chr3:10068473 FANCD2;CIDECP 1.02 13.77 0.6 2.25e-34 Alzheimer's disease; CRC cis rs9311474 0.508 rs4687546 chr3:52605943 T/A cg05573699 chr3:52720067 GNL3;PBRM1 -0.44 -6.45 -0.34 3.94e-10 Electroencephalogram traits; CRC cis rs9303280 0.806 rs2305480 chr17:38062196 G/A cg00129232 chr17:37814104 STARD3 -0.48 -7.52 -0.38 5.31e-13 Self-reported allergy; CRC cis rs10751667 0.666 rs7394992 chr11:980690 G/C cg01483505 chr11:975446 AP2A2 0.46 7.62 0.39 2.71e-13 Alzheimer's disease (late onset); CRC cis rs853679 0.517 rs55747925 chr6:28044337 T/C cg12172441 chr6:28176163 NA 0.59 7.12 0.37 6.82e-12 Depression; CRC cis rs7208859 0.573 rs8078656 chr17:29080971 A/T cg13385521 chr17:29058706 SUZ12P 0.72 8.18 0.41 6.46e-15 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC trans rs4771996 0.508 rs9554404 chr13:98249364 T/C cg03311339 chr17:64299562 PRKCA -0.47 -6.17 -0.32 2.05e-9 Obesity-related traits; CRC cis rs9311474 0.508 rs12629701 chr3:52619836 T/C cg15147215 chr3:52552868 STAB1 -0.63 -10.97 -0.52 4.6e-24 Electroencephalogram traits; CRC cis rs10504229 0.683 rs7838958 chr8:58136968 T/C cg02290350 chr8:58132656 NA -0.58 -8.16 -0.41 7.29e-15 Developmental language disorder (linguistic errors); CRC trans rs1997103 1.000 rs6953509 chr7:55412179 G/A cg20935933 chr6:143382018 AIG1 0.51 6.63 0.34 1.35e-10 QRS interval (sulfonylurea treatment interaction); CRC trans rs10502219 0.958 rs12362410 chr11:116422860 C/T cg20778451 chr5:178368205 ZNF454 -0.34 -6.27 -0.33 1.15e-9 Mitochondrial DNA levels; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg15818800 chr10:22292583 DNAJC1 0.47 6.09 0.32 3.06e-9 Thyroid stimulating hormone; CRC cis rs896854 0.967 rs2879813 chr8:95960947 A/G cg13393036 chr8:95962371 TP53INP1 -0.54 -9.31 -0.46 1.86e-18 Type 2 diabetes; CRC cis rs7772486 0.743 rs1292339 chr6:145967086 C/T cg05347473 chr6:146136440 FBXO30 -0.37 -5.66 -0.3 3.27e-8 Lobe attachment (rater-scored or self-reported); CRC cis rs6764363 0.504 rs4684335 chr3:283415 T/C cg02057681 chr3:285234 CHL1 0.42 7.08 0.36 8.63e-12 Sudden cardiac arrest; CRC cis rs9435341 0.965 rs2335104 chr1:107583641 A/T cg14828511 chr1:107599125 PRMT6 0.45 6.57 0.34 1.97e-10 Facial morphology (factor 21, depth of nasal alae); CRC cis rs2404602 0.583 rs11072580 chr15:76540231 G/A cg00316803 chr15:76480434 C15orf27 -0.39 -6.66 -0.34 1.18e-10 Blood metabolite levels; CRC cis rs34779708 0.966 rs12774834 chr10:35400070 A/T cg03585969 chr10:35415529 CREM 0.66 8.73 0.43 1.33e-16 Inflammatory bowel disease;Crohn's disease; CRC cis rs875971 0.545 rs6979636 chr7:65741625 A/G cg03233332 chr7:66118400 NA -0.43 -6.45 -0.34 3.89e-10 Aortic root size; CRC cis rs4509693 0.943 rs10732789 chr10:102496184 T/C cg23167259 chr10:102495509 NA -0.46 -6.28 -0.33 1.08e-9 Alzheimer's disease; CRC cis rs1008375 1.000 rs2872958 chr4:17665032 A/G cg04450456 chr4:17643702 FAM184B 0.4 6.43 0.33 4.37e-10 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs13118159 0.573 rs4974618 chr4:1373663 C/T cg16405210 chr4:1374714 KIAA1530 -0.94 -15.29 -0.64 3.07e-40 Longevity; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg22273042 chr8:81083829 TPD52 0.38 6.57 0.34 1.92e-10 Liver disease severity in Alagille syndrome; CRC cis rs7552404 1.000 rs9662166 chr1:76235906 C/A cg03433033 chr1:76189801 ACADM 0.77 10.47 0.5 2.55e-22 Blood metabolite levels;Acylcarnitine levels; CRC cis rs8060686 0.858 rs20549 chr16:67969930 A/G cg01951491 chr16:67709440 GFOD2 -0.46 -5.73 -0.3 2.28e-8 HDL cholesterol;Metabolic syndrome; CRC cis rs6951245 1.000 rs11767527 chr7:1097394 T/C cg03188948 chr7:1209495 NA 0.65 6.84 0.35 3.8e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs9303280 0.617 rs4795406 chr17:38100134 G/C cg24910161 chr17:38119198 GSDMA -0.32 -5.62 -0.3 4.07e-8 Self-reported allergy; CRC cis rs929596 0.755 rs887829 chr2:234668570 A/G cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 0.69 10.97 0.52 4.49e-24 Total bilirubin levels in HIV-1 infection; CRC cis rs1580019 0.523 rs9791770 chr7:32582252 C/A cg14728415 chr7:32535168 LSM5;AVL9 0.45 6.38 0.33 5.97e-10 Cognitive ability; CRC cis rs7208859 0.623 rs9911490 chr17:29073013 C/T cg01831904 chr17:28903510 LRRC37B2 -0.62 -6.39 -0.33 5.8e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs7103648 0.630 rs7120548 chr11:47662932 A/G cg20307385 chr11:47447363 PSMC3 0.84 12.34 0.56 5.1e-29 Diastolic blood pressure;Systolic blood pressure; CRC cis rs7666738 0.830 rs10470951 chr4:99037051 G/A cg17366294 chr4:99064904 C4orf37 0.44 7.47 0.38 7.18e-13 Colonoscopy-negative controls vs population controls; CRC cis rs929354 1.000 rs929354 chr7:157045557 C/T cg17757837 chr7:157058334 UBE3C -0.78 -14.54 -0.63 2.49e-37 Body mass index; CRC cis rs9487051 1.000 rs6568570 chr6:109613241 T/G cg01475377 chr6:109611718 NA -0.45 -7.97 -0.4 2.71e-14 Reticulocyte fraction of red cells; CRC cis rs4144743 1.000 rs72823474 chr17:45321776 G/C cg18085866 chr17:45331354 ITGB3 -0.6 -8.31 -0.42 2.54e-15 Body mass index; CRC cis rs35110281 0.811 rs2838339 chr21:45075750 A/G cg04455712 chr21:45112962 RRP1B -0.41 -8.04 -0.41 1.69e-14 Mean corpuscular volume; CRC cis rs9527 0.640 rs6584541 chr10:104929124 A/G cg04362960 chr10:104952993 NT5C2 0.61 8.44 0.42 1.03e-15 Arsenic metabolism; CRC cis rs9926296 0.605 rs12709094 chr16:89853017 A/G cg27121462 chr16:89883253 FANCA 0.57 9.06 0.45 1.18e-17 Vitiligo; CRC cis rs853679 0.666 rs200956 chr6:27839746 A/G cg02683197 chr6:28174875 NA 0.63 7.22 0.37 3.55e-12 Depression; CRC cis rs2692947 0.537 rs11688045 chr2:96243805 A/T cg23100626 chr2:96804247 ASTL 0.23 5.69 0.3 2.84e-8 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; CRC cis rs875971 0.862 rs7803416 chr7:65954199 A/G cg00343986 chr7:65444356 GUSB 0.44 6.39 0.33 5.77e-10 Aortic root size; CRC cis rs7647973 0.560 rs77473999 chr3:49777660 T/C cg13072238 chr3:49761600 GMPPB 0.52 5.65 0.3 3.46e-8 Menarche (age at onset); CRC cis rs1401999 1.000 rs6443927 chr3:183718864 A/G cg05044414 chr3:183734942 ABCC5 0.47 8.13 0.41 9.07e-15 Anterior chamber depth; CRC cis rs9837602 0.938 rs10511177 chr3:99724873 A/G cg07805332 chr3:99536008 MIR548G;C3orf26 0.51 6.78 0.35 5.45e-11 Breast cancer; CRC cis rs2795502 0.938 rs2744085 chr10:43341976 C/T cg27426351 chr10:43362370 NA 0.59 7.06 0.36 9.89e-12 Blood protein levels; CRC cis rs4665809 0.877 rs35224700 chr2:26298037 T/C cg22920501 chr2:26401640 FAM59B 0.56 6.73 0.35 7.73e-11 Gut microbiome composition (summer); CRC cis rs11105298 0.891 rs11105299 chr12:89877943 A/G cg00757033 chr12:89920650 WDR51B 0.38 6.34 0.33 7.78e-10 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; CRC cis rs4478858 0.662 rs6425735 chr1:31783945 T/C cg07478791 chr1:31886160 SERINC2 -0.41 -5.86 -0.31 1.14e-8 Alcohol dependence; CRC cis rs7178572 0.962 rs12324627 chr15:77767539 A/G cg22256960 chr15:77711686 NA -0.7 -10.84 -0.51 1.34e-23 Type 2 diabetes; CRC cis rs13315871 1.000 rs13317835 chr3:58383275 C/T cg20936604 chr3:58311152 NA -0.71 -6.53 -0.34 2.5e-10 Cholesterol, total; CRC trans rs61931739 0.500 rs7489270 chr12:34432062 C/T cg26384229 chr12:38710491 ALG10B 0.66 8.81 0.44 7.3e-17 Morning vs. evening chronotype; CRC cis rs6088590 0.610 rs6120663 chr20:33081906 A/C cg24642439 chr20:33292090 TP53INP2 -0.52 -8.68 -0.43 1.91e-16 Coronary artery disease; CRC cis rs4819052 0.851 rs9977178 chr21:46664531 G/T cg11663144 chr21:46675770 NA -0.82 -14.27 -0.62 2.62e-36 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs10504229 0.683 rs16921814 chr8:58107421 A/T cg02290350 chr8:58132656 NA -0.59 -7.8 -0.39 8.35e-14 Developmental language disorder (linguistic errors); CRC cis rs4713118 0.824 rs742046 chr6:27739254 A/G cg15845792 chr6:28175446 NA 0.68 8.99 0.44 2e-17 Parkinson's disease; CRC cis rs9494145 0.667 rs1331309 chr6:135406178 T/G cg22676075 chr6:135203613 NA 0.61 7.85 0.4 5.94e-14 Mean platelet volume;Platelet count;Fetal hemoglobin levels in sickle cell anemia;Red blood cell traits; CRC cis rs13064447 0.753 rs9811396 chr3:12747915 A/G cg07775309 chr3:12595852 NA -0.37 -5.96 -0.31 6.46e-9 Major depression and alcohol dependence; CRC cis rs11080107 0.542 rs894606 chr17:27909352 C/T cg26525008 chr17:28256777 EFCAB5;SSH2 0.46 6.49 0.34 3.13e-10 Coronary artery disease; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg01140101 chr1:202113040 ARL8A 0.48 6.97 0.36 1.79e-11 Response to antipsychotic treatment; CRC cis rs4713118 0.628 rs9295740 chr6:27689502 G/A cg03623178 chr6:28175578 NA 0.49 5.8 0.3 1.56e-8 Parkinson's disease; CRC cis rs6502050 0.835 rs3935403 chr17:80114145 C/T cg22110888 chr17:80059540 CCDC57 0.41 6.51 0.34 2.86e-10 Life satisfaction; CRC cis rs72634258 0.519 rs2071984 chr1:7928656 C/T cg26816564 chr1:7831052 VAMP3 0.63 7.74 0.39 1.25e-13 Inflammatory bowel disease; CRC cis rs4363385 0.693 rs576941 chr1:153040165 A/G cg25856811 chr1:152973957 SPRR3 0.24 6.63 0.34 1.41e-10 Inflammatory skin disease; CRC cis rs875971 0.862 rs2420174 chr7:65645361 C/T cg12463550 chr7:65579703 CRCP -0.54 -7.69 -0.39 1.7e-13 Aortic root size; CRC cis rs9674544 0.757 rs9896443 chr17:47125982 A/G cg10950924 chr17:47092072 IGF2BP1 -0.35 -5.77 -0.3 1.82e-8 Primary tooth development (time to first tooth eruption);Primary tooth development (number of teeth); CRC cis rs13191362 0.935 rs34587258 chr6:162945580 T/C cg06582575 chr6:163149167 PACRG;PARK2 0.77 9.23 0.45 3.47e-18 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC trans rs8073060 0.586 rs7214250 chr17:33981704 C/G cg19694781 chr19:47549865 TMEM160 -1.05 -14.84 -0.63 1.67e-38 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; CRC cis rs13217239 0.646 rs10946888 chr6:26951678 A/G cg05192639 chr6:26864778 GUSBL1 0.3 5.7 0.3 2.71e-8 Schizophrenia; CRC cis rs7789940 0.951 rs7779014 chr7:75975586 C/T cg10167463 chr7:75959203 YWHAG -0.78 -11.45 -0.53 9.15e-26 Multiple sclerosis; CRC cis rs10540 0.818 rs12806089 chr11:501468 G/A cg03934478 chr11:495069 RNH1 0.69 7.77 0.39 9.92e-14 Body mass index; CRC cis rs644148 0.836 rs2686777 chr19:45000386 T/C cg15540054 chr19:45004280 ZNF180 -0.59 -8.28 -0.42 3.11e-15 Personality dimensions; CRC cis rs1865760 0.519 rs4360119 chr6:25815074 C/G cg17691542 chr6:26056736 HIST1H1C 0.73 9.4 0.46 9.58e-19 Height; CRC cis rs853679 0.760 rs11962305 chr6:28199937 G/C cg03623178 chr6:28175578 NA 0.75 7.86 0.4 5.45e-14 Depression; CRC cis rs9612 1.000 rs347519 chr19:44273516 T/C cg08581076 chr19:44259116 C19orf61 0.46 6.02 0.31 4.78e-9 Exhaled nitric oxide output; CRC cis rs1790761 0.967 rs1638556 chr11:67213518 A/G cg17375396 chr11:67202808 RPS6KB2 0.34 5.72 0.3 2.37e-8 Mean corpuscular volume; CRC trans rs12797204 0.793 rs71465556 chr11:83461366 T/C cg07421806 chr5:128301136 SLC27A6 -0.6 -5.97 -0.31 6.12e-9 Cerebrospinal fluid t-tau:AB1-42 ratio; CRC cis rs2576037 0.526 rs1893427 chr18:44434987 C/T cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.64 -10.32 -0.49 8e-22 Personality dimensions; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg05663122 chr19:59055778 TRIM28 0.41 6.35 0.33 6.97e-10 Intelligence (multi-trait analysis); CRC trans rs2727020 0.538 rs61885230 chr11:49128958 T/C cg03929089 chr4:120376271 NA -0.55 -8.09 -0.41 1.2e-14 Coronary artery disease; CRC cis rs7917772 0.636 rs2249850 chr10:104512006 A/G cg11453585 chr10:104263688 ACTR1A;SUFU 0.76 10.52 0.5 1.69e-22 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC cis rs9527 0.590 rs12775302 chr10:104911356 A/G cg15744005 chr10:104629667 AS3MT -0.31 -6.1 -0.32 3.03e-9 Arsenic metabolism; CRC cis rs938554 0.784 rs10939638 chr4:9977675 T/A cg00071950 chr4:10020882 SLC2A9 0.47 6.65 0.34 1.21e-10 Blood metabolite levels; CRC trans rs7267979 0.816 rs390123 chr20:25480105 C/G cg17903999 chr18:56338584 MALT1 -0.4 -6.55 -0.34 2.27e-10 Liver enzyme levels (alkaline phosphatase); CRC cis rs2204008 0.774 rs7304438 chr12:38361146 T/G cg26384229 chr12:38710491 ALG10B 0.69 9.8 0.48 4.77e-20 Bladder cancer; CRC cis rs3741404 0.895 rs2429455 chr11:63995302 C/G cg06219103 chr11:63990595 FERMT3 -0.38 -5.96 -0.31 6.56e-9 Platelet count; CRC cis rs9894429 0.690 rs12949956 chr17:79542813 C/T cg21028142 chr17:79581711 NPLOC4 -0.34 -7.14 -0.37 6.14e-12 Eye color traits; CRC cis rs28386778 0.897 rs894406 chr17:61901657 A/G cg11494091 chr17:61959527 GH2 0.6 10.1 0.49 4.51e-21 Prudent dietary pattern; CRC cis rs11212617 0.935 rs183459 chr11:108089197 G/T cg12106634 chr11:108092400 ATM;NPAT 0.39 5.68 0.3 2.91e-8 Response to metformin in type 2 diabetes (glycemic); CRC cis rs7149337 1.000 rs8006432 chr14:51731306 A/T cg23942311 chr14:51606299 NA 0.65 11.16 0.52 9.82e-25 Cancer; CRC cis rs2712184 0.967 rs1014680 chr2:217672824 A/G cg05032264 chr2:217675019 NA 0.33 5.73 0.3 2.28e-8 Glomerular filtration rate;Glomerular filtration rate in non diabetics (creatinine); CRC cis rs3768617 0.754 rs6673768 chr1:182983396 G/T ch.1.3577855R chr1:183094577 LAMC1 0.61 8.99 0.44 2.02e-17 Fuchs's corneal dystrophy; CRC trans rs459571 0.606 rs457420 chr9:136909261 A/G cg09836344 chr4:1243392 C4orf42;CTBP1 0.45 5.99 0.31 5.47e-9 Platelet distribution width; CRC cis rs10046574 0.831 rs10261625 chr7:135173544 C/T cg27474649 chr7:135195673 CNOT4 0.66 5.61 0.3 4.4e-8 Peripheral arterial disease (traffic-related air pollution interaction); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg00546594 chr21:35287829 ATP5O 0.41 6.28 0.33 1.05e-9 Liver disease severity in Alagille syndrome; CRC cis rs4253772 0.513 rs12171124 chr22:46710693 A/C cg24881330 chr22:46731750 TRMU 0.58 6.16 0.32 2.08e-9 LDL cholesterol;Cholesterol, total; CRC cis rs9322193 0.923 rs9404048 chr6:149937324 C/T cg13206674 chr6:150067644 NUP43 0.63 9.56 0.47 2.91e-19 Lung cancer; CRC trans rs4650994 0.625 rs6681354 chr1:178526279 A/G cg05059571 chr16:84539110 KIAA1609 -0.45 -6.84 -0.35 3.76e-11 HDL cholesterol levels;HDL cholesterol; CRC trans rs7647973 0.626 rs1352889 chr3:49652148 T/C cg21659725 chr3:3221576 CRBN -0.66 -7.38 -0.38 1.34e-12 Menarche (age at onset); CRC cis rs2179367 0.959 rs628488 chr6:149719400 G/A cg07828024 chr6:149772892 ZC3H12D -0.38 -6.0 -0.31 5.23e-9 Dupuytren's disease; CRC cis rs2522056 1.000 rs7730247 chr5:131781288 A/C cg24060327 chr5:131705240 SLC22A5 0.42 5.92 0.31 8.02e-9 Lymphocyte counts;Fibrinogen; CRC cis rs478304 0.651 rs11532071 chr11:65500198 C/A cg27068330 chr11:65405492 SIPA1 -0.66 -10.19 -0.49 2.28e-21 Acne (severe); CRC cis rs6835098 1.000 rs10031414 chr4:174084953 A/C cg08422745 chr4:174089978 GALNT7 -0.95 -16.14 -0.66 1.48e-43 Dementia and core Alzheimer's disease neuropathologic changes; CRC cis rs7264396 1.000 rs224440 chr20:34159447 C/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.45 -7.66 -0.39 2.06e-13 Total cholesterol levels; CRC cis rs9648716 1.000 rs10272940 chr7:140569152 A/G cg10747023 chr7:140774559 NA 0.43 5.66 0.3 3.34e-8 Type 2 diabetes; CRC cis rs412000 0.560 rs4793583 chr17:56451407 A/C cg12560992 chr17:57184187 TRIM37 -0.79 -13.04 -0.58 1.28e-31 Primary tooth development (time to first tooth eruption); CRC trans rs1916521 0.519 rs2461900 chr10:57420539 T/C cg16731318 chr1:94313343 NA -0.43 -6.01 -0.31 4.85e-9 Cardiac hypertrophy; CRC cis rs7493 1.000 rs7493 chr7:95034775 C/G cg20119798 chr7:94954144 PON1 0.47 6.05 0.32 4.04e-9 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs10857712 0.950 rs10857711 chr10:135224059 G/A cg19904058 chr10:135279010 LOC619207 -0.37 -7.01 -0.36 1.33e-11 Systemic lupus erythematosus; CRC cis rs6582630 0.502 rs4379906 chr12:38295673 G/A cg26384229 chr12:38710491 ALG10B 0.66 9.7 0.47 9.87e-20 Drug-induced liver injury (flucloxacillin); CRC cis rs1799949 0.965 rs8176161 chr17:41241390 C/A cg19454999 chr17:41278357 BRCA1;NBR2 0.57 8.9 0.44 3.69e-17 Menopause (age at onset); CRC cis rs7927771 1.000 rs4752797 chr11:47874364 C/T cg05585544 chr11:47624801 NA -0.61 -10.79 -0.51 1.98e-23 Subjective well-being; CRC cis rs4566357 0.595 rs6707159 chr2:227909339 T/A cg11843606 chr2:227700838 RHBDD1 -0.43 -6.67 -0.35 1.06e-10 Coronary artery disease; CRC cis rs11098499 0.731 rs9995026 chr4:120490499 T/A cg09307838 chr4:120376055 NA 0.68 10.09 0.49 4.78e-21 Corneal astigmatism; CRC cis rs425277 0.606 rs451061 chr1:2075068 C/G cg24578937 chr1:2090814 PRKCZ 0.37 6.85 0.35 3.73e-11 Height; CRC cis rs2710642 0.962 rs4671051 chr2:63032696 A/T cg17519650 chr2:63277830 OTX1 -0.43 -6.1 -0.32 2.95e-9 LDL cholesterol levels;LDL cholesterol; CRC cis rs1218582 0.596 rs11264275 chr1:154825270 G/T cg06221963 chr1:154839813 KCNN3 0.55 9.11 0.45 8e-18 Prostate cancer; CRC cis rs10870270 0.913 rs115236491 chr10:133766855 T/G cg08754478 chr10:133766260 PPP2R2D -0.66 -9.33 -0.46 1.67e-18 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; CRC cis rs7692995 1.000 rs7692995 chr4:17936634 T/C cg08925142 chr4:18023851 LCORL -0.53 -5.83 -0.31 1.34e-8 Height; CRC cis rs780096 0.526 rs780102 chr2:27659491 T/C cg12000995 chr2:27665139 KRTCAP3 -0.32 -6.75 -0.35 6.69e-11 Total body bone mineral density; CRC cis rs644799 1.000 rs546809 chr11:95579938 A/G cg25478527 chr11:95522999 CEP57;FAM76B 0.52 7.82 0.4 7.39e-14 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs10540 1.000 rs79440439 chr11:478147 A/C cg03576123 chr11:487126 PTDSS2 -1.1 -10.57 -0.5 1.11e-22 Body mass index; CRC cis rs9916302 0.904 rs7503069 chr17:37697128 C/G cg00129232 chr17:37814104 STARD3 -0.55 -8.14 -0.41 8.5e-15 Glomerular filtration rate (creatinine); CRC cis rs7216064 1.000 rs6504549 chr17:65888784 A/G cg12091567 chr17:66097778 LOC651250 -0.62 -7.62 -0.39 2.81e-13 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CRC cis rs12142240 0.698 rs56049453 chr1:46835468 A/G cg00530320 chr1:46809349 NSUN4 0.6 8.16 0.41 7.02e-15 Menopause (age at onset); CRC cis rs270601 0.770 rs1007602 chr5:131602166 T/C cg12564285 chr5:131593104 PDLIM4 0.54 10.42 0.5 3.71e-22 Acylcarnitine levels; CRC cis rs1552244 0.572 rs6442154 chr3:10168785 A/G cg00166722 chr3:10149974 C3orf24 0.65 7.7 0.39 1.56e-13 Alzheimer's disease; CRC cis rs4927850 0.709 rs6783079 chr3:195652708 T/C cg23245007 chr3:195682326 NA -0.4 -5.63 -0.3 3.81e-8 Pancreatic cancer; CRC cis rs6963495 0.818 rs6956234 chr7:105149707 A/G cg02135003 chr7:105160482 PUS7 -0.89 -12.26 -0.56 9.87e-29 Bipolar disorder (body mass index interaction); CRC cis rs853679 0.517 rs9357066 chr6:28129831 T/C cg06470822 chr6:28175283 NA 1.03 13.59 0.6 1.04e-33 Depression; CRC cis rs11711311 1.000 rs3806641 chr3:113465761 T/G cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.51 -6.94 -0.36 2.14e-11 IgG glycosylation; CRC cis rs875971 0.789 rs7808013 chr7:66071196 A/G cg18252515 chr7:66147081 NA 0.43 6.14 0.32 2.35e-9 Aortic root size; CRC cis rs11608355 0.545 rs12819142 chr12:109896316 G/T cg05360138 chr12:110035743 NA 0.75 7.63 0.39 2.49e-13 Neuroticism; CRC cis rs2857891 0.909 rs17191140 chr11:6944283 G/A cg17958423 chr11:6947583 ZNF215 0.58 6.06 0.32 3.82e-9 Response to cytadine analogues (cytosine arabinoside); CRC cis rs7786808 0.615 rs4909209 chr7:158194329 C/T cg01191920 chr7:158217561 PTPRN2 -0.71 -11.55 -0.54 4.04e-26 Obesity-related traits; CRC cis rs2652834 0.904 rs7175602 chr15:63367032 T/C cg05507819 chr15:63340323 TPM1 -0.47 -6.32 -0.33 8.68e-10 HDL cholesterol; CRC cis rs10170846 0.924 rs3768973 chr2:223436402 C/T cg25565276 chr2:223520875 FARSB 0.59 7.87 0.4 5.34e-14 Schizophrenia (inflammation and infection response interaction); CRC cis rs79349575 0.783 rs62075852 chr17:47017176 T/C cg00947319 chr17:47005597 UBE2Z -0.34 -5.89 -0.31 9.32e-9 Type 2 diabetes; CRC cis rs11758351 0.660 rs77337633 chr6:26233610 T/C cg08260959 chr6:26240920 HIST1H4F -0.35 -5.73 -0.3 2.24e-8 Gout;Renal underexcretion gout; CRC cis rs1881797 0.932 rs4551631 chr1:247667663 C/T cg21399703 chr1:247681439 NA -0.52 -9.06 -0.45 1.16e-17 Acute lymphoblastic leukemia (childhood); CRC cis rs7312933 0.584 rs6582395 chr12:42700141 T/C cg19980929 chr12:42632907 YAF2 0.43 6.3 0.33 9.74e-10 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CRC cis rs4409675 0.576 rs11247706 chr1:28213983 G/C cg23691781 chr1:28212827 C1orf38 0.34 7.76 0.39 1.11e-13 Corneal astigmatism; CRC cis rs919433 0.684 rs55775495 chr2:198245965 C/T cg10820045 chr2:198174542 NA 0.45 7.96 0.4 2.8e-14 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC cis rs7773004 0.601 rs13210340 chr6:26326314 G/A cg13736514 chr6:26305472 NA -0.45 -7.3 -0.37 2.12e-12 Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for body mass index;Waist circumference adjusted for BMI in non-smokers;Waist circumference adjusted for BMI (adjusted for smoking behaviour); CRC cis rs10504229 0.775 rs10504228 chr8:58162053 T/G cg05313129 chr8:58192883 C8orf71 -0.49 -6.25 -0.33 1.3e-9 Developmental language disorder (linguistic errors); CRC trans rs9784649 1.000 rs9784649 chr5:25011524 G/A cg08600765 chr20:34638493 LOC647979 -0.64 -7.55 -0.38 4.2e-13 Peripheral arterial disease (traffic-related air pollution interaction); CRC trans rs931812 0.757 rs4734014 chr8:101908844 A/G cg20993868 chr7:22813445 NA 0.45 9.0 0.44 1.85e-17 Attention deficit hyperactivity disorder and conduct disorder; CRC cis rs270601 0.710 rs371709 chr5:131583240 A/G cg09877947 chr5:131593287 PDLIM4 0.56 9.62 0.47 1.78e-19 Acylcarnitine levels; CRC cis rs10256972 0.577 rs2949179 chr7:1209885 C/G cg22907277 chr7:1156413 C7orf50 0.66 10.3 0.49 9.26e-22 Longevity;Endometriosis; CRC trans rs1656966 1.000 rs1656966 chr3:186466252 C/T cg20164915 chr1:149871167 BOLA1 0.4 6.15 0.32 2.23e-9 Myopia (pathological); CRC cis rs1862618 0.802 rs832547 chr5:56183941 C/G cg24531977 chr5:56204891 C5orf35 -0.84 -10.92 -0.52 6.54e-24 Initial pursuit acceleration; CRC cis rs6120849 0.754 rs3746436 chr20:33586193 C/T cg24642439 chr20:33292090 TP53INP2 0.44 5.68 0.3 3.04e-8 Protein C levels; CRC cis rs11105298 0.891 rs1054807 chr12:89913419 C/T cg08166232 chr12:89918718 WDR51B;GALNT4 -0.63 -7.88 -0.4 4.75e-14 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; CRC cis rs7020830 0.898 rs7857936 chr9:37078491 T/C cg14294708 chr9:37120828 ZCCHC7 1.1 22.12 0.77 4.7e-67 Schizophrenia; CRC cis rs12995491 0.731 rs55705009 chr2:88500718 T/G cg07952391 chr2:88470173 THNSL2 -0.44 -6.4 -0.33 5.21e-10 Response to metformin (IC50); CRC cis rs6570726 0.967 rs373704 chr6:145860618 C/A cg05347473 chr6:146136440 FBXO30 0.4 6.28 0.33 1.08e-9 Lobe attachment (rater-scored or self-reported); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg06688411 chr11:65153958 FRMD8 0.46 6.33 0.33 7.8e-10 Response to antipsychotic treatment; CRC cis rs995000 0.965 rs1179765 chr1:63010110 G/C cg19896129 chr1:63156450 NA -0.44 -6.78 -0.35 5.74e-11 Triglyceride levels; CRC trans rs2727020 0.729 rs2866328 chr11:49282421 A/G cg15704280 chr7:45808275 SEPT13 0.87 15.26 0.64 3.78e-40 Coronary artery disease; CRC cis rs6502050 0.667 rs9892469 chr17:80093657 T/C cg11859384 chr17:80120422 CCDC57 -0.37 -5.94 -0.31 7.25e-9 Life satisfaction; CRC cis rs2032447 0.832 rs6922788 chr6:26052291 C/T cg12310025 chr6:25882481 NA -0.48 -6.8 -0.35 5.07e-11 Intelligence (multi-trait analysis); CRC cis rs1506636 0.962 rs2896335 chr7:123376855 A/T cg03229431 chr7:123269106 ASB15 -0.74 -11.75 -0.54 7.63e-27 Plateletcrit;Platelet count; CRC cis rs921968 0.608 rs678814 chr2:219359287 T/C cg02176678 chr2:219576539 TTLL4 0.48 7.96 0.4 2.84e-14 Mean corpuscular hemoglobin concentration; CRC cis rs977987 0.843 rs35737321 chr16:75439185 A/T cg03315344 chr16:75512273 CHST6 0.52 8.82 0.44 7.06e-17 Dupuytren's disease; CRC cis rs1691799 0.867 rs1168330 chr12:66763167 C/T cg16791601 chr12:66731901 HELB 0.66 10.66 0.51 5.52e-23 White blood cell count (basophil); CRC cis rs9359856 0.529 rs72919916 chr6:90489773 G/A cg13799429 chr6:90582589 CASP8AP2 -0.72 -7.75 -0.39 1.15e-13 Bipolar disorder; CRC cis rs1801251 0.778 rs2250654 chr2:233752376 A/T cg25237894 chr2:233734115 C2orf82 -0.63 -10.88 -0.51 9.62e-24 Coronary artery disease; CRC cis rs863345 0.604 rs11264977 chr1:158447852 G/T cg12129480 chr1:158549410 OR10X1 -0.29 -5.92 -0.31 8.16e-9 Pneumococcal bacteremia; CRC cis rs6502050 0.835 rs8065210 chr17:80090960 G/A cg19223190 chr17:80058835 NA 0.39 6.32 0.33 8.75e-10 Life satisfaction; CRC cis rs1799949 1.000 rs11657053 chr17:41191129 G/T cg05368731 chr17:41323189 NBR1 0.69 10.07 0.49 5.76e-21 Menopause (age at onset); CRC cis rs8072100 0.967 rs4338849 chr17:45512483 A/G cg08085267 chr17:45401833 C17orf57 -0.72 -11.96 -0.55 1.24e-27 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs1552244 1.000 rs55822690 chr3:10128003 A/G cg08888203 chr3:10149979 C3orf24 0.72 10.0 0.48 9.57e-21 Alzheimer's disease; CRC cis rs6963495 0.818 rs73192126 chr7:105175415 T/C cg13798780 chr7:105162888 PUS7 0.68 8.04 0.41 1.59e-14 Bipolar disorder (body mass index interaction); CRC cis rs2836974 0.831 rs6517521 chr21:40551588 A/G cg11644478 chr21:40555479 PSMG1 0.83 12.68 0.57 2.87e-30 Cognitive function; CRC cis rs28386778 0.897 rs4968599 chr17:61835992 T/C cg23090583 chr17:61904693 PSMC5;FTSJ3 1.05 20.23 0.74 1.07e-59 Prudent dietary pattern; CRC cis rs6762 0.550 rs8672 chr11:838634 C/G cg03116740 chr11:841335 TSPAN4;POLR2L -0.4 -6.69 -0.35 9.72e-11 Mean platelet volume; CRC cis rs995000 0.899 rs1168031 chr1:62967987 C/T cg19896129 chr1:63156450 NA -0.39 -6.08 -0.32 3.29e-9 Triglyceride levels; CRC cis rs10463316 0.855 rs352701 chr5:150736474 A/G cg03212797 chr5:150827313 SLC36A1 -0.52 -7.95 -0.4 2.94e-14 Metabolite levels (Pyroglutamine); CRC cis rs8062405 0.757 rs2411453 chr16:28632021 A/C cg16576597 chr16:28551801 NUPR1 -0.41 -5.97 -0.31 6.01e-9 Cognitive ability (multi-trait analysis);Cognitive ability; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg05610379 chr10:123734658 NSMCE4A 0.43 7.02 0.36 1.27e-11 Liver disease severity in Alagille syndrome; CRC cis rs1577917 0.785 rs1885607 chr6:86394905 A/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A 0.7 9.47 0.46 5.46e-19 Response to antipsychotic treatment; CRC cis rs9322193 0.962 rs9322220 chr6:150104033 G/C cg07701084 chr6:150067640 NUP43 0.47 6.61 0.34 1.51e-10 Lung cancer; CRC cis rs10504229 0.817 rs78138632 chr8:58191341 G/T cg11062466 chr8:58055876 NA 0.49 5.67 0.3 3.14e-8 Developmental language disorder (linguistic errors); CRC cis rs10504229 0.593 rs80174614 chr8:58024631 G/A cg22535103 chr8:58192502 C8orf71 -0.53 -6.32 -0.33 8.44e-10 Developmental language disorder (linguistic errors); CRC cis rs10512697 0.541 rs35183718 chr5:3498590 A/C cg19473799 chr5:3511975 NA -0.82 -6.32 -0.33 8.41e-10 Immune response to smallpox vaccine (IL-6); CRC cis rs3996993 0.809 rs6910581 chr6:52735825 T/C cg20803780 chr6:52668592 GSTA1 0.37 6.85 0.35 3.6e-11 Hemoglobin concentration; CRC trans rs17685 0.753 rs10251863 chr7:75790192 T/C cg19862616 chr7:65841803 NCRNA00174 0.97 16.87 0.68 1.91e-46 Coffee consumption;Coffee consumption (cups per day); CRC cis rs8031584 0.918 rs34693097 chr15:31253984 A/G cg14829155 chr15:31115871 NA -0.5 -8.18 -0.41 6.15e-15 Huntington's disease progression; CRC cis rs6500602 0.727 rs1477123 chr16:4560627 T/A cg13763550 chr16:4524223 NMRAL1;HMOX2 0.44 5.62 0.3 4e-8 Schizophrenia; CRC cis rs7312933 0.558 rs1669936 chr12:42813509 C/A cg11827402 chr12:42719852 PPHLN1;ZCRB1 -0.66 -9.74 -0.47 7.31e-20 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CRC cis rs875971 0.789 rs10260426 chr7:65736042 G/T cg18876405 chr7:65276391 NA -0.52 -8.34 -0.42 2.06e-15 Aortic root size; CRC cis rs709400 1.000 rs57218990 chr14:104128007 T/A cg12935359 chr14:103987150 CKB -0.4 -6.61 -0.34 1.55e-10 Body mass index; CRC cis rs1218582 0.774 rs11264284 chr1:154875793 C/T cg09359103 chr1:154839909 KCNN3 -0.74 -12.94 -0.58 3.16e-31 Prostate cancer; CRC cis rs853679 0.574 rs1233705 chr6:28166447 C/G cg03623178 chr6:28175578 NA 1.0 15.19 0.64 7.35e-40 Depression; CRC cis rs727505 1.000 rs10246424 chr7:124494861 A/G cg23710748 chr7:124431027 NA -0.83 -14.63 -0.63 1.07e-37 Lewy body disease; CRC cis rs8180040 0.726 rs10461018 chr3:46995242 C/T cg02527881 chr3:46936655 PTH1R 0.4 7.2 0.37 4.17e-12 Colorectal cancer; CRC cis rs1552244 1.000 rs7610821 chr3:10136150 C/T cg02579736 chr3:10068473 FANCD2;CIDECP 0.94 12.82 0.58 8.7e-31 Alzheimer's disease; CRC cis rs597539 0.617 rs672853 chr11:68636362 G/A cg06112835 chr11:68658793 MRPL21 0.48 7.48 0.38 6.98e-13 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs4665809 1.000 rs4233710 chr2:26291565 G/A cg27170947 chr2:26402098 FAM59B -0.45 -5.67 -0.3 3.09e-8 Gut microbiome composition (summer); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg21192376 chr14:53020168 GPR137C;TXNDC16 0.42 7.21 0.37 3.94e-12 Liver disease severity in Alagille syndrome; CRC cis rs7927592 0.913 rs12284933 chr11:68319489 G/A cg16797656 chr11:68205561 LRP5 0.36 5.71 0.3 2.47e-8 Total body bone mineral density; CRC cis rs7772486 0.754 rs9497434 chr6:146260753 C/T cg13319975 chr6:146136371 FBXO30 0.44 6.62 0.34 1.49e-10 Lobe attachment (rater-scored or self-reported); CRC cis rs10540 0.908 rs1044707 chr11:491334 G/T cg03576123 chr11:487126 PTDSS2 0.96 10.01 0.48 9.1e-21 Body mass index; CRC cis rs10504229 0.953 rs17805380 chr8:58171128 C/A cg02290350 chr8:58132656 NA -0.42 -5.96 -0.31 6.62e-9 Developmental language disorder (linguistic errors); CRC cis rs6951245 0.935 rs113365567 chr7:1108785 T/C cg26224354 chr7:1096374 C7orf50;GPR146 -0.95 -12.32 -0.56 5.95e-29 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs12630931 0.691 rs4637318 chr3:31994962 T/C cg21375017 chr3:31988082 OSBPL10 0.46 7.12 0.37 6.74e-12 Periodontal disease-related phenotypes; CRC cis rs9648716 1.000 rs9648696 chr7:140449150 T/C cg10747023 chr7:140774559 NA 0.44 5.77 0.3 1.8e-8 Type 2 diabetes; CRC cis rs2204008 0.536 rs12368354 chr12:38042798 G/A cg26384229 chr12:38710491 ALG10B 0.68 9.03 0.45 1.48e-17 Bladder cancer; CRC cis rs7927771 0.832 rs11607981 chr11:47401060 T/G cg05585544 chr11:47624801 NA -0.5 -8.98 -0.44 2.06e-17 Subjective well-being; CRC cis rs11212617 0.967 rs227058 chr11:108265213 T/C cg12106634 chr11:108092400 ATM;NPAT 0.44 6.52 0.34 2.64e-10 Response to metformin in type 2 diabetes (glycemic); CRC cis rs10791323 0.538 rs1105494 chr11:133698733 A/C cg15485101 chr11:133734466 NA -0.35 -5.6 -0.3 4.52e-8 Childhood ear infection; CRC cis rs875971 1.000 rs697970 chr7:65560052 G/C cg11764359 chr7:65958608 NA -0.61 -9.64 -0.47 1.5e-19 Aortic root size; CRC cis rs4665809 0.590 rs1865324 chr2:26417533 C/A cg04944784 chr2:26401820 FAM59B -0.82 -10.57 -0.5 1.14e-22 Gut microbiome composition (summer); CRC cis rs589448 0.867 rs623853 chr12:69753830 G/A cg22834771 chr12:69754056 YEATS4 -0.56 -8.78 -0.44 9.17e-17 Cerebrospinal fluid biomarker levels; CRC cis rs4253772 0.530 rs6008616 chr22:46707954 A/G cg24881330 chr22:46731750 TRMU 0.59 6.36 0.33 6.75e-10 LDL cholesterol;Cholesterol, total; CRC cis rs6089584 0.850 rs881993 chr20:60623862 A/G cg12751644 chr20:60527061 NA -0.37 -5.62 -0.3 4.15e-8 Body mass index; CRC cis rs2742417 0.603 rs9826208 chr3:45773991 C/T cg04837898 chr3:45731254 SACM1L -0.48 -7.69 -0.39 1.74e-13 Response to anti-depressant treatment in major depressive disorder; CRC cis rs11250464 0.517 rs2892335 chr10:1432136 T/G cg02408697 chr10:1416920 ADARB2 0.4 5.69 0.3 2.86e-8 Radiation response; CRC cis rs5758511 0.773 rs62240997 chr22:42354567 T/G cg00645731 chr22:42541494 CYP2D7P1 0.47 6.99 0.36 1.51e-11 Birth weight; CRC cis rs7043114 0.525 rs7047089 chr9:95117980 C/T cg13798575 chr9:95087839 CENPP;NOL8 -0.4 -5.87 -0.31 1.07e-8 Height; CRC trans rs13046373 0.905 rs4816372 chr21:32077414 A/T cg23843100 chr6:142627231 GPR126 -0.38 -5.98 -0.31 5.7e-9 HDL cholesterol; CRC cis rs11098499 0.955 rs11931312 chr4:120159023 T/C cg09307838 chr4:120376055 NA 0.62 9.63 0.47 1.73e-19 Corneal astigmatism; CRC cis rs8105895 0.935 rs7254050 chr19:22286741 G/A cg02912127 chr19:22235281 ZNF257 -0.41 -5.7 -0.3 2.62e-8 Body mass index (change over time); CRC cis rs9682041 0.696 rs11927807 chr3:170096623 A/G cg11886554 chr3:170076028 SKIL 0.69 8.26 0.41 3.55e-15 Glomerular filtration rate in non diabetics (creatinine);Glomerular filtration rate (creatinine); CRC cis rs10504229 0.775 rs55764517 chr8:58158238 G/A cg05313129 chr8:58192883 C8orf71 -0.48 -6.25 -0.33 1.29e-9 Developmental language disorder (linguistic errors); CRC cis rs8180040 0.966 rs6800271 chr3:47470787 A/T cg10298567 chr3:47292165 KIF9 0.35 5.74 0.3 2.15e-8 Colorectal cancer; CRC cis rs9311676 0.656 rs11915190 chr3:58409700 G/A cg06643156 chr3:58380774 PXK 0.42 6.38 0.33 5.84e-10 Systemic lupus erythematosus; CRC trans rs264162 0.655 rs1354813 chr18:11000418 C/T cg03091010 chr18:73167894 NA -0.32 -6.15 -0.32 2.2e-9 Stem cell growth factor beta levels; CRC cis rs2243480 1.000 rs6460261 chr7:65215580 T/C cg25985355 chr7:65971099 NA 0.5 5.84 0.31 1.28e-8 Diabetic kidney disease; CRC cis rs7412746 0.611 rs11803940 chr1:150685835 A/G cg10589385 chr1:150898437 SETDB1 0.29 6.19 0.32 1.81e-9 Melanoma; CRC cis rs172166 0.694 rs203893 chr6:28062066 C/A cg20615401 chr6:28092323 ZSCAN16 0.46 5.99 0.31 5.44e-9 Cardiac Troponin-T levels; CRC cis rs9303401 0.615 rs7502342 chr17:56922629 C/A cg02118635 chr17:56770003 RAD51C;TEX14 0.78 9.94 0.48 1.59e-20 Cognitive test performance; CRC cis rs597539 0.652 rs513359 chr11:68669496 A/T cg06112835 chr11:68658793 MRPL21 -0.47 -7.71 -0.39 1.46e-13 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs7932354 0.502 rs10769233 chr11:47072655 T/C cg19486271 chr11:47235900 DDB2 -0.44 -6.59 -0.34 1.74e-10 Bone mineral density (hip);Bone mineral density; CRC cis rs911119 0.913 rs34792920 chr20:23581876 C/T cg16589663 chr20:23618590 CST3 0.57 7.03 0.36 1.16e-11 Chronic kidney disease; CRC cis rs6743226 0.811 rs10933537 chr2:242154930 C/G cg10021735 chr2:242295487 FARP2 -0.46 -6.82 -0.35 4.49e-11 Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI in non-smokers; CRC cis rs17443541 0.507 rs1823489 chr2:200463825 C/G cg03741458 chr2:200468445 NA -0.36 -5.76 -0.3 1.91e-8 Intelligence (multi-trait analysis); CRC cis rs9467773 0.626 rs9379860 chr6:26370605 T/C cg14345882 chr6:26364793 BTN3A2 0.41 6.43 0.33 4.61e-10 Intelligence (multi-trait analysis); CRC cis rs1448094 0.511 rs4897823 chr12:86161484 C/T cg18827107 chr12:86230957 RASSF9 -0.39 -6.07 -0.32 3.59e-9 Major depressive disorder; CRC cis rs6502050 0.805 rs7406858 chr17:80080623 G/A cg22110888 chr17:80059540 CCDC57 -0.41 -6.38 -0.33 6.13e-10 Life satisfaction; CRC cis rs12024301 0.557 rs76617854 chr1:183608743 T/G cg11505048 chr1:183622726 RGL1;APOBEC4 0.81 6.83 0.35 4.19e-11 Peripheral arterial disease (traffic-related air pollution interaction); CRC trans rs3733585 0.664 rs28602527 chr4:9958327 G/A cg26043149 chr18:55253948 FECH -0.5 -7.62 -0.39 2.81e-13 Cleft plate (environmental tobacco smoke interaction); CRC trans rs116095464 0.558 rs56127718 chr5:270273 G/T cg00938859 chr5:1591904 SDHAP3 0.73 7.92 0.4 3.76e-14 Breast cancer; CRC cis rs9491140 0.539 rs12204076 chr6:124693493 A/G cg22366943 chr6:124882293 NKAIN2 0.56 8.01 0.4 2.05e-14 Neuroticism; CRC cis rs546131 0.928 rs546521 chr11:34824773 G/C cg24088639 chr11:34937564 PDHX;APIP -0.42 -5.84 -0.31 1.29e-8 Lung disease severity in cystic fibrosis; CRC cis rs7618915 0.571 rs17264436 chr3:52610651 T/A cg15147215 chr3:52552868 STAB1 -0.63 -10.56 -0.5 1.22e-22 Bipolar disorder; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg13710969 chr17:79393463 BAHCC1 0.27 6.25 0.33 1.3e-9 Liver disease severity in Alagille syndrome; CRC cis rs4972806 0.849 rs2857541 chr2:177029086 C/T cg13092806 chr2:177043255 NA 0.79 12.58 0.57 6.51e-30 IgG glycosylation; CRC cis rs11628318 0.853 rs7140280 chr14:103026991 C/T cg23461800 chr14:103021989 NA -0.49 -6.48 -0.34 3.32e-10 Platelet count; CRC trans rs8035957 1.000 rs4924273 chr15:38846738 C/G cg04798930 chr2:37193060 STRN -0.53 -6.06 -0.32 3.75e-9 Type 1 diabetes; CRC cis rs4319547 0.585 rs7952868 chr12:122846949 A/G cg05707623 chr12:122985044 ZCCHC8 -0.7 -8.07 -0.41 1.29e-14 Body mass index; CRC cis rs11252926 0.673 rs7096559 chr10:499188 C/T cg16386425 chr10:429943 DIP2C -0.39 -5.66 -0.3 3.25e-8 Psychosis in Alzheimer's disease; CRC trans rs7615952 0.800 rs11915699 chr3:125632684 A/G cg02007433 chr3:129722099 NA -0.47 -5.97 -0.31 6.04e-9 Blood pressure (smoking interaction); CRC cis rs12024301 0.557 rs7526521 chr1:183590453 A/G cg11505048 chr1:183622726 RGL1;APOBEC4 0.76 6.93 0.36 2.16e-11 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs9372498 0.536 rs9489467 chr6:118935206 C/T cg22561889 chr6:118971681 C6orf204 0.52 6.62 0.34 1.45e-10 Diastolic blood pressure; CRC cis rs7835763 0.719 rs2956390 chr8:119104103 A/G cg11592677 chr8:119110466 EXT1 -0.38 -6.18 -0.32 1.93e-9 Autism spectrum disorder; CRC cis rs12291225 0.535 rs11023203 chr11:14409815 G/A cg19336497 chr11:14380999 RRAS2 -0.47 -8.07 -0.41 1.3e-14 Sense of smell; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg03509965 chr14:75743987 FOS 0.44 6.23 0.32 1.42e-9 Anxiety disorder; CRC cis rs853679 0.760 rs9393910 chr6:28208192 C/G cg12273811 chr6:28175739 NA 0.55 5.86 0.31 1.12e-8 Depression; CRC cis rs2180341 0.618 rs11961994 chr6:127649350 A/G cg24812749 chr6:127587940 RNF146 -0.65 -9.83 -0.48 3.54e-20 Breast cancer; CRC cis rs7246657 0.943 rs10406177 chr19:37907947 G/A cg23950597 chr19:37808831 NA -0.49 -6.09 -0.32 3.18e-9 Coronary artery calcification; CRC cis rs6582630 0.634 rs10748443 chr12:38734062 G/T cg26384229 chr12:38710491 ALG10B 0.53 8.04 0.41 1.68e-14 Drug-induced liver injury (flucloxacillin); CRC cis rs8180040 0.966 rs57346147 chr3:47410564 C/G cg27129171 chr3:47204927 SETD2 -0.61 -9.33 -0.46 1.57e-18 Colorectal cancer; CRC cis rs72945132 0.825 rs58532402 chr11:70189491 C/T cg00319359 chr11:70116639 PPFIA1 0.57 6.23 0.32 1.43e-9 Coronary artery disease; CRC cis rs7786877 0.761 rs11772705 chr7:100298904 T/C cg20848291 chr7:100343083 ZAN -0.63 -9.84 -0.48 3.31e-20 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs7927771 1.000 rs11039412 chr11:47841581 G/A cg05585544 chr11:47624801 NA -0.61 -10.76 -0.51 2.45e-23 Subjective well-being; CRC cis rs17401966 0.838 rs7553935 chr1:10375179 G/A cg19773385 chr1:10388646 KIF1B -0.61 -9.35 -0.46 1.35e-18 Hepatocellular carcinoma; CRC cis rs769267 0.930 rs3794993 chr19:19611550 G/T cg01262667 chr19:19385393 TM6SF2 0.34 5.72 0.3 2.44e-8 Tonsillectomy; CRC cis rs1448094 0.511 rs17345299 chr12:86166005 C/G cg02569458 chr12:86230093 RASSF9 0.46 7.46 0.38 7.87e-13 Major depressive disorder; CRC cis rs1223397 0.938 rs3734878 chr6:13288850 C/T cg20827128 chr6:13274284 PHACTR1 0.56 6.6 0.34 1.67e-10 Blood pressure; CRC cis rs4481887 1.000 rs6671789 chr1:248482931 G/A cg13385794 chr1:248469461 NA 0.39 6.7 0.35 8.96e-11 Common traits (Other); CRC cis rs3785574 0.927 rs2727313 chr17:61961914 A/G cg25654072 chr17:61904446 PSMC5;FTSJ3 0.42 5.79 0.3 1.63e-8 Height; CRC cis rs7917772 0.636 rs2482499 chr10:104516246 G/A cg22532475 chr10:104410764 TRIM8 -0.33 -5.64 -0.3 3.6e-8 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC cis rs5769765 0.773 rs9616382 chr22:50312979 C/T cg02269571 chr22:50332266 NA -0.61 -7.92 -0.4 3.64e-14 Schizophrenia; CRC cis rs6570726 0.791 rs443628 chr6:145883484 T/C cg13319975 chr6:146136371 FBXO30 -0.44 -6.55 -0.34 2.2e-10 Lobe attachment (rater-scored or self-reported); CRC cis rs2882667 0.690 rs160400 chr5:138063019 A/G cg09476006 chr5:138032270 NA -0.56 -9.91 -0.48 2.04e-20 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs28386778 0.897 rs6504185 chr17:61848792 A/G cg06873352 chr17:61820015 STRADA 0.79 14.96 0.64 5.82e-39 Prudent dietary pattern; CRC cis rs9875589 0.957 rs6778297 chr3:13932143 C/T cg19554555 chr3:13937349 NA 0.43 6.15 0.32 2.3e-9 Ovarian reserve; CRC cis rs782590 0.764 rs2054728 chr2:55818419 C/T cg18811423 chr2:55921094 PNPT1 0.77 13.51 0.6 2.08e-33 Metabolic syndrome; CRC cis rs1577917 0.958 rs3857480 chr6:86535149 T/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.49 -6.58 -0.34 1.82e-10 Response to antipsychotic treatment; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg01516580 chr16:19179433 SYT17 0.41 6.02 0.31 4.76e-9 Intelligence (multi-trait analysis); CRC trans rs6951245 1.000 rs78896566 chr7:1080182 C/G cg13565492 chr6:43139072 SRF -0.71 -7.27 -0.37 2.61e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs6831352 0.918 rs2602894 chr4:100045647 A/G cg13256891 chr4:100009986 ADH5 0.65 8.93 0.44 3.15e-17 Alcohol dependence; CRC cis rs1007738 0.507 rs10742797 chr11:47240490 A/T cg19486271 chr11:47235900 DDB2 0.48 6.86 0.35 3.49e-11 Bone mineral density (hip); CRC cis rs514406 0.861 rs7518390 chr1:53233374 A/G cg25767906 chr1:53392781 SCP2 0.44 7.03 0.36 1.2e-11 Monocyte count; CRC cis rs35520189 0.591 rs12618418 chr2:113707645 G/T cg12858261 chr2:113808755 IL1F8 0.45 5.96 0.31 6.61e-9 Obstructive sleep apnea trait (apnea hypopnea index); CRC cis rs7617773 0.780 rs4541431 chr3:48365218 G/C cg11946769 chr3:48343235 NME6 0.72 9.58 0.47 2.48e-19 Coronary artery disease; CRC cis rs12594515 1.000 rs11070467 chr15:45985001 C/T cg01629716 chr15:45996671 NA -0.41 -8.29 -0.42 2.98e-15 Waist circumference;Weight; CRC trans rs34421088 0.560 rs2248315 chr8:11397086 T/A cg06636001 chr8:8085503 FLJ10661 -0.51 -7.51 -0.38 5.56e-13 Neuroticism; CRC cis rs7917772 0.503 rs1536308 chr10:104288777 T/G cg11453585 chr10:104263688 ACTR1A;SUFU 0.9 16.75 0.68 5.87e-46 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC cis rs34172651 0.517 rs11862923 chr16:24767303 G/T cg04756594 chr16:24857601 SLC5A11 0.33 6.87 0.35 3.29e-11 Intelligence (multi-trait analysis); CRC cis rs6662572 0.703 rs9429090 chr1:46502393 A/G cg08644498 chr1:46502608 NA 0.45 7.05 0.36 1.03e-11 Blood protein levels; CRC cis rs6502050 0.734 rs9674631 chr17:80096525 A/G cg02741985 chr17:80059408 CCDC57 0.43 7.14 0.37 5.9e-12 Life satisfaction; CRC cis rs10743315 0.778 rs10841184 chr12:19370768 T/G cg02471346 chr12:19282374 PLEKHA5 -0.62 -7.6 -0.39 3.03e-13 Gut microbiota (bacterial taxa); CRC cis rs7666738 0.830 rs28687737 chr4:99009226 G/A cg05340658 chr4:99064831 C4orf37 0.61 9.54 0.47 3.44e-19 Colonoscopy-negative controls vs population controls; CRC cis rs853679 0.517 rs9393897 chr6:28127710 G/T cg02631126 chr6:28058918 ZSCAN12L1 0.29 5.91 0.31 8.38e-9 Depression; CRC cis rs11229555 0.645 rs35279927 chr11:58212129 G/T cg15696309 chr11:58395628 NA -0.82 -10.31 -0.49 8.59e-22 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; CRC cis rs629535 0.814 rs651985 chr8:70054966 G/A cg26132723 chr8:70041827 NA 0.35 5.69 0.3 2.78e-8 Dupuytren's disease; CRC cis rs4665809 0.549 rs17527979 chr2:26428132 A/G cg22920501 chr2:26401640 FAM59B -0.82 -10.73 -0.51 3.13e-23 Gut microbiome composition (summer); CRC cis rs9296092 0.560 rs9469502 chr6:33526648 G/A cg13560919 chr6:33536144 NA -0.44 -6.28 -0.33 1.09e-9 Age at smoking initiation in chronic obstructive pulmonary disease; CRC cis rs10089 0.953 rs6887674 chr5:127531183 G/C cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.75 9.73 0.47 7.6e-20 Ileal carcinoids; CRC cis rs9649213 0.574 rs7791321 chr7:97944125 G/C cg24562669 chr7:97807699 LMTK2 0.44 7.28 0.37 2.52e-12 Prostate cancer (SNP x SNP interaction); CRC cis rs875971 0.830 rs4718358 chr7:65973668 T/C cg18912574 chr7:65842487 NCRNA00174 0.35 5.95 0.31 6.72e-9 Aortic root size; CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg08943809 chr16:58059531 MMP15 0.36 5.96 0.31 6.45e-9 Obesity-related traits; CRC cis rs4845875 0.557 rs6659541 chr1:11836442 G/A cg02448276 chr1:11845238 NA 0.36 5.61 0.3 4.38e-8 Midregional pro atrial natriuretic peptide levels; CRC cis rs1448094 0.617 rs952851 chr12:86477341 C/T cg02569458 chr12:86230093 RASSF9 -0.42 -7.07 -0.36 9.59e-12 Major depressive disorder; CRC cis rs6831352 0.840 rs29001223 chr4:100047433 C/T cg13256891 chr4:100009986 ADH5 -0.65 -8.72 -0.43 1.42e-16 Alcohol dependence; CRC cis rs3772130 0.962 rs9878086 chr3:121488353 G/A cg20356878 chr3:121714668 ILDR1 0.51 7.85 0.4 5.79e-14 Cognitive performance; CRC cis rs250677 0.687 rs36043 chr5:148440983 G/A cg23229984 chr5:148520753 ABLIM3 0.47 6.61 0.34 1.56e-10 Breast cancer; CRC cis rs13382862 0.895 rs13385499 chr2:20882413 A/G cg12334488 chr2:20871173 GDF7 -0.32 -5.92 -0.31 7.95e-9 Abdominal aortic aneurysm; CRC cis rs12681287 0.604 rs13279589 chr8:87477723 C/T cg27223183 chr8:87520930 FAM82B -0.53 -7.52 -0.38 5.31e-13 Caudate activity during reward; CRC cis rs1223397 0.938 rs34505804 chr6:13292514 G/A cg21538684 chr6:13274180 PHACTR1 0.48 5.63 0.3 3.89e-8 Blood pressure; CRC cis rs7786808 0.615 rs4909209 chr7:158194329 C/T cg15440763 chr7:158190612 PTPRN2 0.53 8.71 0.43 1.54e-16 Obesity-related traits; CRC trans rs6693295 0.729 rs10802326 chr1:246216665 T/C cg03680032 chr11:94965610 SESN3 0.49 6.12 0.32 2.68e-9 Migraine - clinic-based;Migraine with aura; CRC cis rs56104184 0.775 rs73061695 chr19:49399988 T/C cg21252483 chr19:49399788 TULP2 -0.43 -6.62 -0.34 1.49e-10 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; CRC cis rs1008375 1.000 rs17507481 chr4:17620066 A/G cg02297831 chr4:17616191 MED28 0.46 6.07 0.32 3.43e-9 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs4665809 0.590 rs1368902 chr2:26440576 T/C cg25036284 chr2:26402008 FAM59B -0.61 -7.76 -0.39 1.09e-13 Gut microbiome composition (summer); CRC cis rs317689 0.690 rs10878947 chr12:69642683 A/T cg20891283 chr12:69753455 YEATS4 0.48 6.11 0.32 2.78e-9 Response to diuretic therapy; CRC cis rs9916302 0.851 rs6503502 chr17:37501855 A/G cg03013999 chr17:37608204 MED1 -0.48 -7.42 -0.38 9.94e-13 Glomerular filtration rate (creatinine); CRC cis rs6496667 0.642 rs62019395 chr15:91066309 G/T cg04176472 chr15:90893244 GABARAPL3 0.49 7.23 0.37 3.4e-12 Rheumatoid arthritis; CRC trans rs1005277 0.579 rs1780146 chr10:38517874 C/A cg17830980 chr10:43048298 ZNF37B -0.6 -9.99 -0.48 1.07e-20 Extrinsic epigenetic age acceleration; CRC cis rs13108904 0.967 rs2293635 chr4:1291791 A/G cg00684032 chr4:1343700 KIAA1530 0.47 6.78 0.35 5.74e-11 Obesity-related traits; CRC cis rs2404602 0.647 rs12898416 chr15:77042292 C/G cg03037974 chr15:76606532 NA -0.54 -7.78 -0.39 9.15e-14 Blood metabolite levels; CRC cis rs35110281 0.626 rs162368 chr21:44934767 G/A cg01579765 chr21:45077557 HSF2BP -0.36 -6.72 -0.35 8.16e-11 Mean corpuscular volume; CRC cis rs4665809 0.627 rs7562192 chr2:26469457 C/G cg26119090 chr2:26468346 HADHA;HADHB 1.0 14.56 0.63 2.14e-37 Gut microbiome composition (summer); CRC cis rs4713118 0.539 rs200988 chr6:27819353 A/C cg08798685 chr6:27730294 NA -0.42 -6.17 -0.32 2e-9 Parkinson's disease; CRC cis rs9875589 0.509 rs2168718 chr3:14084157 A/G cg14375111 chr3:14165186 TMEM43;CHCHD4 0.39 5.98 0.31 5.86e-9 Ovarian reserve; CRC trans rs7647973 0.626 rs62262672 chr3:49655927 T/A cg21665057 chr3:196295764 WDR53;FBXO45 0.62 6.39 0.33 5.59e-10 Menarche (age at onset); CRC cis rs11711311 1.000 rs7622403 chr3:113472434 A/G cg15478005 chr3:113465772 ATP6V1A;NAA50 -0.43 -6.02 -0.31 4.73e-9 IgG glycosylation; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg03442064 chr6:41515050 FOXP4 0.48 6.19 0.32 1.81e-9 Thyroid stimulating hormone; CRC cis rs12477438 0.765 rs4851183 chr2:99629149 G/T cg14399236 chr2:99771627 LIPT1;TSGA10 -0.6 -8.22 -0.41 4.6e-15 Chronic sinus infection; CRC cis rs9976767 0.861 rs9980448 chr21:43839730 T/C cg23042151 chr21:43824109 UBASH3A -0.33 -5.8 -0.3 1.55e-8 Type 1 diabetes; CRC cis rs13108904 0.870 rs2279281 chr4:1245277 T/G cg00684032 chr4:1343700 KIAA1530 0.42 6.43 0.33 4.49e-10 Obesity-related traits; CRC cis rs10464366 0.746 rs6945547 chr7:39145389 C/G cg18850127 chr7:39170497 POU6F2 0.5 6.67 0.35 1.06e-10 IgG glycosylation; CRC cis rs6120849 0.754 rs6088667 chr20:33566722 A/C cg08999081 chr20:33150536 PIGU 0.41 5.71 0.3 2.53e-8 Protein C levels; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg09085639 chr17:79670810 MRPL12 0.43 6.2 0.32 1.74e-9 Response to antipsychotic treatment; CRC cis rs2635047 0.901 rs2684837 chr18:44749884 A/C cg19077165 chr18:44547161 KATNAL2 -0.37 -5.77 -0.3 1.85e-8 Educational attainment; CRC cis rs2576037 0.526 rs4890699 chr18:44541029 T/C cg19077165 chr18:44547161 KATNAL2 -0.6 -9.66 -0.47 1.38e-19 Personality dimensions; CRC trans rs8002861 0.713 rs7339417 chr13:44413496 A/T cg12856521 chr11:46389249 DGKZ 0.43 7.01 0.36 1.32e-11 Leprosy; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg02592615 chr6:12012261 HIVEP1 0.38 6.26 0.33 1.19e-9 Liver disease severity in Alagille syndrome; CRC trans rs11098499 0.908 rs28559989 chr4:120386627 C/T cg25214090 chr10:38739885 LOC399744 0.66 10.55 0.5 1.36e-22 Corneal astigmatism; CRC cis rs10193935 1.000 rs58962161 chr2:42400278 T/A cg27598129 chr2:42591480 NA -0.54 -6.49 -0.34 3.15e-10 Colonoscopy-negative controls vs population controls; CRC cis rs58688157 0.660 rs12797496 chr11:583767 C/T cg03909863 chr11:638404 DRD4 -0.51 -6.55 -0.34 2.17e-10 Systemic lupus erythematosus; CRC cis rs897984 0.721 rs4889525 chr16:30989858 T/C cg02466173 chr16:30829666 NA 0.62 9.32 0.46 1.78e-18 Dementia with Lewy bodies; CRC cis rs425277 0.606 rs262653 chr1:2090095 T/G cg03732007 chr1:2071316 PRKCZ 0.36 5.72 0.3 2.34e-8 Height; CRC cis rs9611565 0.512 rs5758439 chr22:42131762 C/T cg06481639 chr22:41940642 POLR3H 0.55 6.19 0.32 1.82e-9 Vitiligo; CRC trans rs56283067 0.887 rs7349931 chr6:44783674 C/T cg16542424 chr3:61546472 PTPRG 0.54 6.15 0.32 2.28e-9 Total body bone mineral density; CRC cis rs1580019 0.587 rs6951955 chr7:32548761 A/T cg06627557 chr7:32535165 LSM5;AVL9 0.97 18.91 0.72 1.7e-54 Cognitive ability; CRC cis rs79387448 0.745 rs17027428 chr2:103163175 G/A cg00507830 chr2:103233733 NA 0.51 5.61 0.3 4.25e-8 Gut microbiota (bacterial taxa); CRC trans rs35110281 0.806 rs1454649 chr21:45032982 C/T cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.52 8.96 0.44 2.47e-17 Mean corpuscular volume; CRC cis rs4713118 0.955 rs9380012 chr6:27684654 A/G cg06470822 chr6:28175283 NA 0.67 9.07 0.45 1.1e-17 Parkinson's disease; CRC cis rs2576037 0.501 rs8089938 chr18:44459497 C/T cg24750912 chr18:44543259 TCEB3CL;KATNAL2 0.3 5.86 0.31 1.11e-8 Personality dimensions; CRC cis rs4665809 0.549 rs62130460 chr2:26472718 T/C cg26119090 chr2:26468346 HADHA;HADHB 1.0 12.74 0.57 1.75e-30 Gut microbiome composition (summer); CRC cis rs1799949 0.965 rs9897425 chr17:41430179 C/G cg07153921 chr17:41440717 NA -0.39 -5.9 -0.31 8.93e-9 Menopause (age at onset); CRC cis rs2286885 0.965 rs4836548 chr9:129255456 G/A cg15282417 chr9:129245246 FAM125B 0.44 8.16 0.41 7.03e-15 Intraocular pressure; CRC cis rs17818399 0.501 rs13413254 chr2:46802934 A/T cg26688816 chr2:46740690 ATP6V1E2 -0.47 -6.96 -0.36 1.85e-11 Height; CRC cis rs10504229 0.728 rs17804774 chr8:58155950 G/T cg02290350 chr8:58132656 NA -0.5 -6.19 -0.32 1.75e-9 Developmental language disorder (linguistic errors); CRC cis rs2361718 1.000 rs2361718 chr17:78103466 C/T cg27427491 chr17:78079615 GAA -0.38 -6.19 -0.32 1.76e-9 Yeast infection; CRC cis rs2933343 0.672 rs1872545 chr3:128645039 G/C cg11901034 chr3:128598214 ACAD9 -0.57 -8.31 -0.42 2.46e-15 IgG glycosylation; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg25267957 chr22:32871051 FBXO7 0.37 5.97 0.31 6.15e-9 Intelligence (multi-trait analysis); CRC cis rs28386778 0.897 rs2584640 chr17:61863488 C/T cg11494091 chr17:61959527 GH2 0.59 10.04 0.48 7.33e-21 Prudent dietary pattern; CRC cis rs7107174 1.000 rs11237438 chr11:77998488 T/C cg02023728 chr11:77925099 USP35 0.54 8.2 0.41 5.59e-15 Testicular germ cell tumor; CRC cis rs9359856 0.564 rs72913975 chr6:90387116 C/T cg13799429 chr6:90582589 CASP8AP2 -0.72 -7.7 -0.39 1.61e-13 Bipolar disorder; CRC cis rs4722166 0.630 rs6969258 chr7:22782528 C/T cg05472934 chr7:22766657 IL6 0.76 12.37 0.56 4.12e-29 Lung cancer; CRC cis rs847577 0.569 rs7804318 chr7:97796635 A/G cg21770322 chr7:97807741 LMTK2 -0.84 -18.42 -0.71 1.5e-52 Breast cancer; CRC cis rs1448094 0.512 rs7970081 chr12:86243392 G/T cg19622623 chr12:86230825 RASSF9 -0.41 -6.7 -0.35 9.04e-11 Major depressive disorder; CRC cis rs4731207 0.596 rs10275346 chr7:124610346 T/C cg23710748 chr7:124431027 NA -0.39 -6.25 -0.33 1.29e-9 Cutaneous malignant melanoma; CRC cis rs6557786 0.636 rs2445940 chr8:24787201 C/G cg04118306 chr8:24772350 NEFM 0.36 5.96 0.31 6.52e-9 Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 2 peripheral neuropathy); CRC trans rs6500957 0.920 rs17648524 chr16:7459683 C/G cg10815400 chr1:65210420 RAVER2 0.43 6.37 0.33 6.4e-10 Spherical equivalent (joint analysis main effects and education interaction); CRC cis rs12472274 0.941 rs36066920 chr2:239074480 T/G cg17459225 chr2:239074497 NA 0.87 14.67 0.63 7.8e-38 Phospholipid levels (plasma); CRC cis rs7666738 0.830 rs9992639 chr4:98940400 G/T cg17366294 chr4:99064904 C4orf37 0.43 7.32 0.37 1.95e-12 Colonoscopy-negative controls vs population controls; CRC cis rs7044106 0.791 rs2416797 chr9:123480600 C/A cg09586646 chr9:123605570 PSMD5;LOC253039 0.62 8.82 0.44 6.77e-17 Hip circumference adjusted for BMI; CRC cis rs4319547 1.000 rs6489157 chr12:123101673 C/G cg23029597 chr12:123009494 RSRC2 0.6 7.82 0.4 7.32e-14 Body mass index; CRC cis rs875971 0.862 rs2420611 chr7:65999320 A/G cg00343986 chr7:65444356 GUSB 0.44 6.16 0.32 2.15e-9 Aortic root size; CRC cis rs780096 0.565 rs10169261 chr2:27727314 C/T cg12000995 chr2:27665139 KRTCAP3 -0.31 -6.41 -0.33 5.15e-10 Total body bone mineral density; CRC trans rs2303319 0.504 rs56009150 chr2:162598582 T/C cg24655899 chr17:79519568 C17orf70 -0.7 -5.98 -0.31 5.92e-9 Cognitive function; CRC cis rs1964356 0.967 rs2953802 chr8:8851881 G/A cg06636001 chr8:8085503 FLJ10661 0.54 7.91 0.4 3.93e-14 Mean corpuscular volume; CRC cis rs6964587 0.869 rs4729010 chr7:91486751 G/A cg17063962 chr7:91808500 NA -0.78 -13.35 -0.59 8.43e-33 Breast cancer; CRC cis rs17345786 0.906 rs11710016 chr3:101120030 A/C cg12386194 chr3:101231763 SENP7 -0.5 -6.19 -0.32 1.8e-9 Colonoscopy-negative controls vs population controls; CRC cis rs758324 0.755 rs578637 chr5:131267609 G/A cg25547332 chr5:131281432 NA -0.37 -6.03 -0.32 4.5e-9 Alzheimer's disease in APOE e4- carriers; CRC cis rs10760158 0.832 rs4837821 chr9:124010519 T/C cg14417974 chr9:124058376 GSN -0.33 -5.64 -0.3 3.58e-8 Pulse pressure; CRC cis rs8180040 1.000 rs2302278 chr3:47361082 G/T cg10298567 chr3:47292165 KIF9 0.41 6.76 0.35 6.15e-11 Colorectal cancer; CRC cis rs60871478 0.786 rs7807878 chr7:833878 T/C cg13844804 chr7:814759 HEATR2 -0.65 -7.39 -0.38 1.25e-12 Cerebrospinal P-tau181p levels; CRC cis rs9393692 0.840 rs9358915 chr6:26277268 G/A cg13736514 chr6:26305472 NA -0.61 -11.46 -0.53 8.56e-26 Educational attainment; CRC trans rs1005277 0.579 rs2474572 chr10:38385316 A/G cg27523141 chr10:43048294 ZNF37B 0.49 7.38 0.38 1.32e-12 Extrinsic epigenetic age acceleration; CRC cis rs9868809 0.505 rs28657585 chr3:48736216 A/T cg07636037 chr3:49044803 WDR6 -0.66 -6.61 -0.34 1.51e-10 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; CRC cis rs28386778 0.897 rs2727327 chr17:61923422 G/A cg11494091 chr17:61959527 GH2 0.63 10.87 0.51 1.04e-23 Prudent dietary pattern; CRC cis rs7901135 0.962 rs4344442 chr10:60577393 A/G cg23799393 chr10:60588674 BICC1 0.38 5.91 0.31 8.34e-9 Morning vs. evening chronotype; CRC cis rs7539542 0.556 rs10753925 chr1:202854488 C/T cg19681188 chr1:202830198 LOC148709 0.46 6.62 0.34 1.49e-10 Mean platelet volume; CRC trans rs629535 0.814 rs571682 chr8:70062793 A/G cg21567404 chr3:27674614 NA 0.88 14.38 0.62 9.75e-37 Dupuytren's disease; CRC cis rs11190604 1.000 rs10786596 chr10:102282126 C/A cg16342193 chr10:102329863 NA -0.33 -5.7 -0.3 2.67e-8 Palmitoleic acid (16:1n-7) levels; CRC cis rs644799 1.000 rs596277 chr11:95566886 G/A cg03916912 chr11:95522834 CEP57;FAM76B 0.96 18.45 0.71 1.13e-52 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs6496667 0.779 rs8037260 chr15:91049960 C/T cg04176472 chr15:90893244 GABARAPL3 0.57 8.28 0.42 3.18e-15 Rheumatoid arthritis; CRC cis rs9430161 0.579 rs7542164 chr1:11040223 G/A cg27631724 chr1:11040367 C1orf127 0.36 7.3 0.37 2.15e-12 Ewing sarcoma; CRC cis rs7666738 0.753 rs7698541 chr4:98986351 T/A cg05340658 chr4:99064831 C4orf37 0.6 9.41 0.46 8.57e-19 Colonoscopy-negative controls vs population controls; CRC cis rs2153535 0.580 rs6900007 chr6:8474035 C/T cg21535247 chr6:8435926 SLC35B3 0.5 7.53 0.38 4.89e-13 Motion sickness; CRC cis rs7618915 0.501 rs2289247 chr3:52727257 C/T cg08222913 chr3:52553049 STAB1 -0.35 -6.44 -0.33 4.13e-10 Bipolar disorder; CRC cis rs12142240 0.738 rs41293277 chr1:46806550 C/T cg14993813 chr1:46806288 NSUN4 -0.5 -6.33 -0.33 7.89e-10 Menopause (age at onset); CRC cis rs425277 0.585 rs3107156 chr1:2060630 T/C cg12639453 chr1:2035780 PRKCZ -0.43 -8.04 -0.41 1.62e-14 Height; CRC cis rs4824093 0.610 rs56810176 chr22:50303149 G/C cg22709217 chr22:50311962 ALG12;CRELD2 -0.89 -8.64 -0.43 2.44e-16 Amyotrophic lateral sclerosis (sporadic); CRC trans rs9467711 0.659 rs34246779 chr6:26549212 G/A cg06606381 chr12:133084897 FBRSL1 -1.07 -7.41 -0.38 1.09e-12 Autism spectrum disorder or schizophrenia; CRC cis rs9393692 0.557 rs9366648 chr6:26306282 T/C cg00631329 chr6:26305371 NA -0.53 -8.81 -0.44 7.53e-17 Educational attainment; CRC cis rs2882667 0.690 rs7722965 chr5:138100455 T/C cg09476006 chr5:138032270 NA -0.56 -9.6 -0.47 2.19e-19 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs1862618 0.853 rs1423620 chr5:56100996 G/T cg12311346 chr5:56204834 C5orf35 -0.71 -9.12 -0.45 7.57e-18 Initial pursuit acceleration; CRC cis rs3858526 1.000 rs11039787 chr11:5965611 C/T cg13902645 chr11:5959945 NA -0.65 -8.86 -0.44 5.29e-17 DNA methylation (variation); CRC cis rs473651 0.935 rs541013 chr2:239336492 G/A cg18131467 chr2:239335373 ASB1 1.02 22.85 0.78 6.89e-70 Multiple system atrophy; CRC trans rs4955793 0.585 rs9872496 chr3:178638752 C/T cg11644478 chr21:40555479 PSMG1 0.66 6.14 0.32 2.36e-9 Post-traumatic stress disorder (asjusted for relatedness); CRC cis rs881375 1.000 rs1953126 chr9:123640500 T/C cg14255062 chr9:123606675 PSMD5;LOC253039 0.41 5.96 0.31 6.59e-9 Rheumatoid arthritis; CRC cis rs10504229 0.861 rs6990617 chr8:58182960 G/T cg02290350 chr8:58132656 NA -0.42 -5.96 -0.31 6.62e-9 Developmental language disorder (linguistic errors); CRC cis rs4665809 0.838 rs6546749 chr2:26306288 T/C cg22920501 chr2:26401640 FAM59B -0.56 -7.36 -0.38 1.48e-12 Gut microbiome composition (summer); CRC cis rs11098499 0.644 rs10009566 chr4:120558608 A/G cg09307838 chr4:120376055 NA 0.61 9.47 0.46 5.5e-19 Corneal astigmatism; CRC cis rs9549367 0.713 rs9549691 chr13:113861606 A/C cg00898013 chr13:113819073 PROZ -0.52 -7.78 -0.39 9.76e-14 Platelet distribution width; CRC cis rs6502050 0.835 rs8077772 chr17:80117220 A/G cg02741985 chr17:80059408 CCDC57 -0.41 -6.76 -0.35 6.14e-11 Life satisfaction; CRC cis rs909674 0.541 rs5750816 chr22:39810379 A/G cg24399712 chr22:39784796 NA 0.5 10.21 0.49 1.89e-21 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; CRC cis rs7927592 0.913 rs10896329 chr11:68250029 A/G cg16797656 chr11:68205561 LRP5 0.39 6.17 0.32 2.02e-9 Total body bone mineral density; CRC cis rs744166 0.600 rs6503695 chr17:40499533 T/C cg06270615 chr17:40516068 STAT3 -0.31 -6.74 -0.35 7.09e-11 Crohn's disease;Multiple sclerosis;Inflammatory bowel disease; CRC cis rs992157 0.835 rs10932768 chr2:219146199 T/A cg04731861 chr2:219085781 ARPC2 0.33 6.91 0.36 2.49e-11 Colorectal cancer; CRC cis rs7940866 0.845 rs1433976 chr11:130875123 C/T cg12179176 chr11:130786555 SNX19 -0.55 -8.02 -0.4 1.84e-14 Schizophrenia; CRC cis rs672059 0.513 rs572977 chr1:183164991 C/G cg05929019 chr1:183155154 LAMC2 -0.38 -6.95 -0.36 1.93e-11 Hypertriglyceridemia; CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg15356674 chr10:79471309 NA -0.53 -6.85 -0.35 3.68e-11 Diisocyanate-induced asthma; CRC cis rs875971 0.545 rs221986 chr7:65570310 T/C cg18876405 chr7:65276391 NA -0.44 -6.08 -0.32 3.36e-9 Aortic root size; CRC cis rs6988636 1.000 rs28694222 chr8:124195017 C/T cg27053337 chr8:124217698 FAM83A 0.42 6.3 0.33 9.38e-10 Urinary uromodulin levels; CRC trans rs7618501 0.633 rs12485600 chr3:50025530 A/G cg21665057 chr3:196295764 WDR53;FBXO45 0.61 9.8 0.48 4.74e-20 Intelligence (multi-trait analysis); CRC cis rs6540559 0.673 rs17015218 chr1:209967915 A/G cg25204440 chr1:209979598 IRF6 0.49 5.88 0.31 1.02e-8 Cleft lip with or without cleft palate; CRC cis rs6502050 0.805 rs56020943 chr17:80105248 C/A cg09264619 chr17:80180166 NA -0.34 -5.81 -0.3 1.5e-8 Life satisfaction; CRC cis rs7811142 0.667 rs3873746 chr7:99935097 G/A cg00814883 chr7:100076585 TSC22D4 -0.65 -8.32 -0.42 2.32e-15 Platelet count; CRC cis rs9322193 0.962 rs3805748 chr6:150093678 C/T cg07701084 chr6:150067640 NUP43 0.48 6.71 0.35 8.7e-11 Lung cancer; CRC cis rs35264875 1.000 rs35264875 chr11:68846399 A/T cg15234197 chr11:68924956 NA 0.43 5.8 0.3 1.54e-8 Blond vs. brown hair color; CRC cis rs7412746 0.658 rs1546376 chr1:150937661 A/G cg17724175 chr1:150552817 MCL1 0.46 6.94 0.36 2.03e-11 Melanoma; CRC cis rs7552404 0.924 rs7535991 chr1:76162624 C/T cg10523679 chr1:76189770 ACADM 0.93 14.17 0.62 6.79e-36 Blood metabolite levels;Acylcarnitine levels; CRC cis rs17023223 0.537 rs2794310 chr1:119561930 C/G cg05756136 chr1:119680316 WARS2 -0.51 -6.93 -0.36 2.19e-11 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for BMI in active individuals; CRC cis rs9462846 0.960 rs12194860 chr6:42862934 C/T cg02353165 chr6:42928485 GNMT 0.48 6.57 0.34 2.03e-10 Blood protein levels; CRC cis rs2050392 0.517 rs656600 chr10:30765654 G/A cg18806716 chr10:30721971 MAP3K8 -0.55 -7.67 -0.39 1.95e-13 Inflammatory bowel disease; CRC cis rs7959452 0.535 rs7135092 chr12:69658330 T/C cg20891283 chr12:69753455 YEATS4 0.78 13.01 0.58 1.65e-31 Blood protein levels; CRC cis rs7927592 0.913 rs4988291 chr11:68381607 G/A cg16797656 chr11:68205561 LRP5 0.36 5.69 0.3 2.81e-8 Total body bone mineral density; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg05441541 chr16:1543911 TELO2 0.47 6.32 0.33 8.45e-10 Anxiety disorder; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg18330637 chr20:18548049 LOC388789 0.38 6.13 0.32 2.45e-9 Liver disease severity in Alagille syndrome; CRC cis rs10504229 0.683 rs55714371 chr8:58131846 T/G cg02290350 chr8:58132656 NA -0.58 -8.16 -0.41 7.29e-15 Developmental language disorder (linguistic errors); CRC cis rs861020 0.630 rs628445 chr1:210004953 C/T cg05527609 chr1:210001259 C1orf107 0.77 10.66 0.51 5.37e-23 Orofacial clefts; CRC cis rs2742417 0.603 rs2742456 chr3:45767176 C/T cg04837898 chr3:45731254 SACM1L -0.46 -7.23 -0.37 3.36e-12 Response to anti-depressant treatment in major depressive disorder; CRC cis rs7959452 0.527 rs4761157 chr12:69780907 A/G cg14784868 chr12:69753453 YEATS4 0.84 14.68 0.63 7.14e-38 Blood protein levels; CRC cis rs13108904 0.870 rs11727987 chr4:1261435 A/G cg16405210 chr4:1374714 KIAA1530 -0.42 -5.89 -0.31 9.42e-9 Obesity-related traits; CRC cis rs9992667 0.955 rs9998440 chr4:38607801 G/T cg19726192 chr4:38663646 FLJ13197 0.56 7.36 0.38 1.47e-12 Eosinophil percentage of granulocytes; CRC cis rs6952808 0.929 rs4721217 chr7:1973579 C/T cg00106254 chr7:1943704 MAD1L1 -0.49 -6.8 -0.35 5.03e-11 Bipolar disorder and schizophrenia; CRC trans rs2303319 0.504 rs961421 chr2:162626099 G/C cg23247704 chr1:116518985 SLC22A15 -0.72 -6.12 -0.32 2.7e-9 Cognitive function; CRC cis rs67478160 0.595 rs8022783 chr14:104245573 T/C cg01849466 chr14:104193079 ZFYVE21 -0.51 -9.01 -0.44 1.73e-17 Schizophrenia; CRC cis rs4664293 0.550 rs13388082 chr2:160472950 C/T cg08347373 chr2:160653686 CD302 -0.39 -6.54 -0.34 2.38e-10 Monocyte percentage of white cells; CRC cis rs1559088 0.895 rs7259582 chr19:33593979 A/G cg27124370 chr19:33622961 WDR88 0.45 6.31 0.33 9.08e-10 Bone ultrasound measurement (broadband ultrasound attenuation); CRC cis rs477692 0.905 rs570967 chr10:131421330 T/G cg05714579 chr10:131428358 MGMT 0.59 8.58 0.43 3.83e-16 Response to temozolomide; CRC cis rs55692411 0.537 rs71326904 chr3:49991060 C/T cg24110177 chr3:50126178 RBM5 -0.49 -5.67 -0.3 3.05e-8 Intelligence (multi-trait analysis); CRC cis rs2580764 0.566 rs2968827 chr2:55297629 C/G cg09592903 chr2:55203963 RTN4 0.65 10.48 0.5 2.32e-22 Mean platelet volume; CRC cis rs11864453 0.578 rs2072141 chr16:72133211 G/A cg23815491 chr16:72088622 HP 0.49 7.51 0.38 5.77e-13 Fibrinogen levels; CRC cis rs11758351 0.660 rs16891455 chr6:26230485 G/A cg01420254 chr6:26195488 NA 0.74 8.14 0.41 8.28e-15 Gout;Renal underexcretion gout; CRC cis rs4713118 0.955 rs9368529 chr6:27684631 G/A cg15786705 chr6:28176104 NA 0.48 6.38 0.33 5.89e-10 Parkinson's disease; CRC cis rs7726839 0.540 rs72707016 chr5:665148 A/G cg16447950 chr5:562315 NA -0.81 -10.49 -0.5 2.1e-22 Obesity-related traits; CRC trans rs9341835 0.772 rs4710254 chr6:64137609 C/T cg13657004 chr13:50234944 EBPL -0.37 -6.22 -0.32 1.48e-9 Schizophrenia; CRC cis rs2204008 0.744 rs11514073 chr12:38399553 A/C cg26384229 chr12:38710491 ALG10B 0.69 9.19 0.45 4.52e-18 Bladder cancer; CRC cis rs7659604 0.539 rs11098646 chr4:122729301 T/C cg06713675 chr4:122721982 EXOSC9 -0.51 -8.24 -0.41 4.19e-15 Type 2 diabetes; CRC trans rs9929218 0.529 rs35854485 chr16:68730855 C/G cg04657470 chr2:198365150 HSPE1;HSPD1 1.05 21.08 0.76 5.23e-63 Colorectal cancer; CRC cis rs2276314 0.802 rs4799838 chr18:33597530 T/C cg05985134 chr18:33552581 C18orf21 0.49 6.43 0.33 4.52e-10 Endometriosis;Drug-induced torsades de pointes; CRC cis rs2288073 0.801 rs10175668 chr2:24367275 G/A cg06627628 chr2:24431161 ITSN2 -0.52 -7.57 -0.39 3.67e-13 Venous thromboembolism (SNP x SNP interaction); CRC cis rs1577917 1.000 rs12196411 chr6:86779762 C/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.6 -7.3 -0.37 2.24e-12 Response to antipsychotic treatment; CRC cis rs9479482 1.000 rs13198863 chr6:150350781 T/G cg25797454 chr6:150327115 RAET1K 0.38 6.42 0.33 4.77e-10 Alopecia areata; CRC trans rs1814175 0.817 rs2866863 chr11:49953242 C/T cg11707556 chr5:10655725 ANKRD33B -0.42 -7.96 -0.4 2.73e-14 Height; CRC cis rs597539 0.652 rs557625 chr11:68634722 G/A cg06112835 chr11:68658793 MRPL21 0.43 6.88 0.35 3.11e-11 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs597539 0.652 rs516425 chr11:68715675 G/A cg06112835 chr11:68658793 MRPL21 0.43 6.89 0.36 2.85e-11 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg02968854 chr7:30518406 NOD1 0.45 6.21 0.32 1.56e-9 Anxiety disorder; CRC cis rs9291683 0.609 rs55959894 chr4:10026580 G/A cg00071950 chr4:10020882 SLC2A9 0.67 12.74 0.57 1.65e-30 Bone mineral density; CRC cis rs11677370 0.561 rs12711973 chr2:3825339 C/G cg17052675 chr2:3827356 NA -0.64 -10.81 -0.51 1.71e-23 Type 2 diabetes; CRC cis rs4713118 0.621 rs9295756 chr6:28033396 G/T cg02683197 chr6:28174875 NA 0.73 8.92 0.44 3.34e-17 Parkinson's disease; CRC cis rs524281 0.861 rs3825067 chr11:65878419 A/G cg16950941 chr11:66035639 RAB1B 0.6 7.43 0.38 9.71e-13 Electroencephalogram traits; CRC trans rs67981189 0.593 rs221917 chr14:71590003 C/T cg09414045 chr1:110162465 AMPD2 -0.4 -6.01 -0.31 4.92e-9 Schizophrenia; CRC cis rs4716602 0.586 rs13224457 chr7:156161005 G/T cg16983916 chr7:156159713 NA -0.39 -6.9 -0.36 2.65e-11 Anti-saccade response; CRC cis rs853679 0.542 rs34131763 chr6:28075000 A/C cg06470822 chr6:28175283 NA 1.0 13.33 0.59 1.04e-32 Depression; CRC trans rs1814175 0.817 rs1794162 chr11:49899506 A/C cg11707556 chr5:10655725 ANKRD33B -0.44 -8.31 -0.42 2.53e-15 Height; CRC cis rs780096 0.546 rs715325 chr2:27725572 C/A cg27432699 chr2:27873401 GPN1 -0.54 -8.36 -0.42 1.76e-15 Total body bone mineral density; CRC cis rs57221529 0.709 rs4957056 chr5:570105 T/C cg16447950 chr5:562315 NA -0.83 -11.24 -0.53 4.92e-25 Lung disease severity in cystic fibrosis; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg16357719 chr16:2317538 RNPS1 0.4 6.68 0.35 1.03e-10 Liver disease severity in Alagille syndrome; CRC cis rs6502050 0.835 rs8081949 chr17:80117490 G/A cg02741985 chr17:80059408 CCDC57 0.43 7.18 0.37 4.57e-12 Life satisfaction; CRC cis rs2882667 0.898 rs11950819 chr5:138397100 T/C cg09476006 chr5:138032270 NA 0.44 7.44 0.38 8.99e-13 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs6499255 1.000 rs6499253 chr16:69802672 C/T cg15192750 chr16:69999425 NA 0.52 6.83 0.35 4.11e-11 IgE levels; CRC cis rs6570726 0.738 rs6925594 chr6:145898454 T/C cg23711669 chr6:146136114 FBXO30 0.69 11.52 0.54 4.94e-26 Lobe attachment (rater-scored or self-reported); CRC cis rs1218582 0.804 rs869506 chr1:154859581 A/C cg24250549 chr1:154909240 PMVK 0.64 10.86 0.51 1.07e-23 Prostate cancer; CRC cis rs3785574 0.962 rs62077483 chr17:61806380 C/T cg25654072 chr17:61904446 PSMC5;FTSJ3 0.43 5.94 0.31 7.3e-9 Height; CRC cis rs62064224 0.546 rs1018866 chr17:30829664 A/C cg12855166 chr17:30846586 MYO1D -0.57 -9.55 -0.47 3e-19 Schizophrenia; CRC cis rs7552404 0.690 rs12723575 chr1:76335203 T/C cg22875332 chr1:76189707 ACADM -0.55 -7.18 -0.37 4.76e-12 Blood metabolite levels;Acylcarnitine levels; CRC cis rs6460942 0.908 rs73677570 chr7:12280329 T/C cg20607287 chr7:12443886 VWDE -0.53 -5.68 -0.3 2.93e-8 Coronary artery disease; CRC trans rs877282 0.891 rs11599917 chr10:762288 G/A cg22713356 chr15:30763199 NA 1.25 14.98 0.64 4.88e-39 Uric acid levels; CRC cis rs7512552 0.809 rs9436108 chr1:150360930 A/G cg15654264 chr1:150340011 RPRD2 0.59 8.65 0.43 2.26e-16 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); CRC cis rs2153535 0.580 rs1932280 chr6:8473654 G/A cg07606381 chr6:8435919 SLC35B3 0.68 10.99 0.52 3.98e-24 Motion sickness; CRC cis rs9660992 0.573 rs1172158 chr1:205208948 G/A cg03948781 chr1:205179583 DSTYK 0.41 5.62 0.3 4.02e-8 Mean corpuscular volume;Mean platelet volume; CRC cis rs3760982 0.585 rs62116964 chr19:44291986 T/C cg11993925 chr19:44307056 LYPD5 0.58 10.26 0.49 1.35e-21 Breast cancer (estrogen-receptor negative);Breast cancer; CRC cis rs55788414 0.932 rs57461213 chr16:81185419 G/C cg06400318 chr16:81190750 PKD1L2 -0.59 -6.76 -0.35 6.2e-11 Left ventricular obstructive tract defect (maternal effect); CRC trans rs1814175 0.647 rs10769646 chr11:49992204 C/A cg03929089 chr4:120376271 NA -0.91 -16.17 -0.67 1.06e-43 Height; CRC cis rs6893807 1.000 rs13163173 chr5:87943620 C/A cg09002922 chr5:87956389 LOC645323 -0.42 -6.05 -0.32 3.83e-9 Body mass index; CRC cis rs875971 0.660 rs12698534 chr7:65986845 C/T cg25985355 chr7:65971099 NA -0.32 -5.67 -0.3 3.2e-8 Aortic root size; CRC cis rs936229 0.861 rs7162232 chr15:75115895 G/A cg14664628 chr15:75095509 CSK -1.02 -19.76 -0.74 7.22e-58 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); CRC trans rs634534 0.622 rs501353 chr11:65739549 T/G cg17712092 chr4:129076599 LARP1B 0.62 10.15 0.49 3.12e-21 Sum eosinophil basophil counts;Eosinophil counts; CRC cis rs4481887 0.927 rs4244184 chr1:248486895 G/T cg00666640 chr1:248458726 OR2T12 0.49 8.29 0.42 3.01e-15 Common traits (Other); CRC trans rs10242455 0.702 rs28377312 chr7:98984213 G/A cg09045935 chr12:6379348 NA 0.94 6.53 0.34 2.52e-10 Blood metabolite levels; CRC cis rs3796619 0.503 rs13147452 chr4:1078124 G/A cg27284194 chr4:1044797 NA 0.6 10.2 0.49 2.15e-21 Recombination rate (males); CRC cis rs9549260 0.755 rs7989711 chr13:41215696 C/T cg21288729 chr13:41239152 FOXO1 0.48 7.61 0.39 2.87e-13 Red blood cell count; CRC cis rs780096 0.587 rs6760828 chr2:27579231 T/C cg12648201 chr2:27665141 KRTCAP3 -0.29 -5.6 -0.3 4.47e-8 Total body bone mineral density; CRC cis rs6502050 0.871 rs8082577 chr17:80070581 T/C cg19223190 chr17:80058835 NA -0.46 -7.25 -0.37 3e-12 Life satisfaction; CRC cis rs9534288 0.659 rs2146882 chr13:46668111 A/G cg15192986 chr13:46630673 CPB2 -0.62 -8.69 -0.43 1.73e-16 Blood protein levels; CRC cis rs9527 0.571 rs7904113 chr10:104633114 G/T cg04362960 chr10:104952993 NT5C2 0.6 8.47 0.42 8.24e-16 Arsenic metabolism; CRC cis rs832540 0.564 rs33329 chr5:56145068 T/C cg24531977 chr5:56204891 C5orf35 -0.53 -7.89 -0.4 4.38e-14 Coronary artery disease; CRC cis rs10832963 0.924 rs10832950 chr11:18635815 A/G cg20219074 chr11:18656078 SPTY2D1 0.61 8.62 0.43 2.78e-16 Breast cancer; CRC cis rs7043114 0.507 rs10992340 chr9:95209693 T/C cg14631576 chr9:95140430 CENPP -0.3 -5.63 -0.3 3.77e-8 Height; CRC cis rs7937682 0.632 rs11214009 chr11:111683142 T/C cg19812747 chr11:111475976 SIK2 0.44 6.37 0.33 6.53e-10 Primary sclerosing cholangitis; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg11698816 chr16:19535587 CP110 0.39 6.65 0.34 1.22e-10 Liver disease severity in Alagille syndrome; CRC cis rs7546094 1.000 rs3103450 chr1:113197730 G/A cg22162597 chr1:113214053 CAPZA1 -0.43 -5.88 -0.31 1.01e-8 Platelet distribution width; CRC cis rs2976388 0.647 rs2572906 chr8:143798269 G/A cg05569086 chr8:143859399 LYNX1 0.38 6.64 0.34 1.27e-10 Urinary tract infection frequency; CRC cis rs3785574 0.638 rs2854182 chr17:61969062 G/A cg22520471 chr17:61851767 DDX42;CCDC47 0.47 6.44 0.33 4.21e-10 Height; CRC cis rs1707322 1.000 rs11211222 chr1:46367757 T/C cg06784218 chr1:46089804 CCDC17 0.52 9.08 0.45 1.05e-17 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs9322193 0.847 rs880246 chr6:150167108 G/A cg07701084 chr6:150067640 NUP43 0.56 8.14 0.41 8.18e-15 Lung cancer; CRC cis rs10979 1.000 rs9390113 chr6:143896205 G/A cg25407410 chr6:143891975 LOC285740 -0.84 -13.84 -0.61 1.22e-34 Hypospadias; CRC cis rs7917772 0.503 rs7904955 chr10:104367092 C/T cg04362960 chr10:104952993 NT5C2 -0.44 -6.13 -0.32 2.56e-9 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC cis rs1865760 0.686 rs12210098 chr6:25963966 C/T cg16482183 chr6:26056742 HIST1H1C 0.53 7.1 0.36 7.72e-12 Height; CRC cis rs28386778 0.901 rs2665855 chr17:61965143 A/G cg11494091 chr17:61959527 GH2 0.62 9.99 0.48 1.03e-20 Prudent dietary pattern; CRC cis rs7208859 0.623 rs1061343 chr17:29114276 G/A cg01831904 chr17:28903510 LRRC37B2 -0.62 -6.41 -0.33 5.13e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs1267303 0.642 rs2404611 chr1:46997127 C/G cg08533674 chr1:46993347 NA -0.61 -7.39 -0.38 1.24e-12 Monobrow; CRC cis rs10512697 0.803 rs17637361 chr5:3580421 G/C cg19473799 chr5:3511975 NA -0.72 -5.71 -0.3 2.47e-8 Immune response to smallpox vaccine (IL-6); CRC cis rs9457247 0.515 rs1951459 chr6:167402536 G/A cg23791538 chr6:167370224 RNASET2 0.49 7.82 0.4 7.19e-14 Crohn's disease; CRC cis rs10242455 0.557 rs73403272 chr7:99134208 T/G cg18809830 chr7:99032528 PTCD1 -1.08 -7.98 -0.4 2.4e-14 Blood metabolite levels; CRC cis rs365302 0.904 rs409843 chr6:159648832 C/T cg14500486 chr6:159655392 FNDC1 0.44 6.87 0.35 3.15e-11 Coronary heart disease; CRC cis rs35146811 0.700 rs2950520 chr7:99827148 T/C cg13334819 chr7:99746414 C7orf59 0.59 7.55 0.38 4.44e-13 Coronary artery disease; CRC cis rs7772486 0.521 rs9485017 chr6:146023326 C/T cg13319975 chr6:146136371 FBXO30 -0.59 -8.89 -0.44 4.19e-17 Lobe attachment (rater-scored or self-reported); CRC cis rs1218582 0.710 rs9794000 chr1:154878876 T/A cg09359103 chr1:154839909 KCNN3 -0.7 -12.29 -0.56 8.14e-29 Prostate cancer; CRC cis rs138880 0.505 rs56248708 chr22:50306969 G/A cg08270630 chr22:50330655 NA -0.54 -5.77 -0.3 1.82e-8 Schizophrenia; CRC cis rs1832871 0.711 rs7747669 chr6:158664345 A/G cg07165851 chr6:158734300 TULP4 0.6 7.53 0.38 4.9e-13 Height; CRC cis rs7264396 0.563 rs2425130 chr20:34335059 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.47 -6.43 -0.33 4.46e-10 Total cholesterol levels; CRC cis rs11997175 0.624 rs10435522 chr8:33698608 G/A cg04338863 chr8:33670619 NA 0.44 6.52 0.34 2.71e-10 Body mass index; CRC cis rs7618501 0.572 rs4688756 chr3:50040194 T/A cg05623727 chr3:50126028 RBM5 0.46 7.77 0.39 1.04e-13 Intelligence (multi-trait analysis); CRC cis rs968567 0.906 rs61897793 chr11:61599347 G/A cg14911132 chr11:61596755 FADS2 -0.56 -5.97 -0.31 6e-9 Blood metabolite levels;Rheumatoid arthritis;Vitiligo;Glycerophospholipid levels; CRC trans rs1997103 1.000 rs6973450 chr7:55396537 A/G cg20935933 chr6:143382018 AIG1 0.52 6.73 0.35 7.57e-11 QRS interval (sulfonylurea treatment interaction); CRC cis rs929354 0.772 rs3802123 chr7:156970641 G/A cg17757837 chr7:157058334 UBE3C 0.77 12.97 0.58 2.41e-31 Body mass index; CRC cis rs4964805 0.594 rs954920 chr12:104173310 A/T cg02344784 chr12:104178138 NT5DC3 0.42 6.14 0.32 2.32e-9 Attention deficit hyperactivity disorder; CRC trans rs3960554 0.867 rs11489553 chr7:75843062 G/A cg19862616 chr7:65841803 NCRNA00174 0.71 7.9 0.4 4.14e-14 Eotaxin levels; CRC cis rs561341 0.941 rs4795664 chr17:30233467 C/T cg19193384 chr17:30244184 NA -0.58 -7.02 -0.36 1.3e-11 Hip circumference adjusted for BMI; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg27619136 chr4:174291353 SAP30 0.47 6.21 0.32 1.63e-9 Thyroid stimulating hormone; CRC cis rs7208859 0.623 rs9915546 chr17:29132144 G/T cg13385521 chr17:29058706 SUZ12P 0.73 8.38 0.42 1.53e-15 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs12142240 0.698 rs72677596 chr1:46833930 C/T cg00530320 chr1:46809349 NSUN4 0.57 7.56 0.38 3.94e-13 Menopause (age at onset); CRC trans rs61931739 0.500 rs11053290 chr12:34582392 C/T cg13010199 chr12:38710504 ALG10B -0.47 -6.66 -0.34 1.15e-10 Morning vs. evening chronotype; CRC cis rs9682041 0.569 rs4955724 chr3:170146532 A/G cg11886554 chr3:170076028 SKIL 0.68 7.65 0.39 2.28e-13 Glomerular filtration rate in non diabetics (creatinine);Glomerular filtration rate (creatinine); CRC cis rs9649213 0.531 rs35216698 chr7:97896175 C/T cg00277769 chr7:97922759 BAIAP2L1 -0.61 -10.42 -0.5 3.56e-22 Prostate cancer (SNP x SNP interaction); CRC cis rs172166 0.694 rs203877 chr6:28048624 T/C cg15786705 chr6:28176104 NA 0.61 8.72 0.43 1.35e-16 Cardiac Troponin-T levels; CRC cis rs6496667 0.779 rs16944431 chr15:90985403 G/T cg04176472 chr15:90893244 GABARAPL3 0.59 8.13 0.41 8.73e-15 Rheumatoid arthritis; CRC cis rs929354 0.772 rs1182360 chr7:157020550 C/G cg16102536 chr7:156981717 UBE3C 0.4 6.79 0.35 5.41e-11 Body mass index; CRC cis rs7666738 0.753 rs2903143 chr4:99040480 C/T cg17366294 chr4:99064904 C4orf37 0.43 7.16 0.37 5.31e-12 Colonoscopy-negative controls vs population controls; CRC cis rs2072499 0.966 rs2842857 chr1:156168736 T/C cg06970220 chr1:156163860 SLC25A44 0.49 7.12 0.37 6.71e-12 Testicular germ cell tumor; CRC cis rs11190604 0.767 rs35508946 chr10:102191156 A/G cg07080220 chr10:102295463 HIF1AN 0.5 6.35 0.33 7.2e-10 Palmitoleic acid (16:1n-7) levels; CRC cis rs7607369 0.714 rs1344643 chr2:219584975 G/C cg02176678 chr2:219576539 TTLL4 -0.52 -8.65 -0.43 2.24e-16 Red blood cell count;Amyotrophic lateral sclerosis; CRC trans rs6550704 0.687 rs9865314 chr3:22634337 A/G cg14599714 chr12:31226825 DDX11 -0.42 -6.06 -0.32 3.64e-9 Daytime sleep phenotypes; CRC trans rs747782 0.528 rs4370963 chr11:48433943 C/G cg15704280 chr7:45808275 SEPT13 0.65 6.25 0.33 1.26e-9 Intraocular pressure; CRC cis rs9926296 0.656 rs11861084 chr16:89875710 G/T cg03605463 chr16:89740564 NA 0.39 5.82 0.31 1.43e-8 Vitiligo; CRC cis rs798766 0.779 rs3134866 chr4:1723265 A/G cg02089348 chr4:1724449 TMEM129;TACC3 -0.4 -5.76 -0.3 1.91e-8 Bladder cancer;Urinary bladder cancer; CRC trans rs11088226 0.581 rs1967870 chr21:33882858 A/G cg09050820 chr6:167586206 TCP10L2 0.52 7.1 0.36 7.61e-12 Gastritis; CRC cis rs7618915 0.570 rs11714088 chr3:52758942 A/C cg18099408 chr3:52552593 STAB1 -0.44 -7.24 -0.37 3.28e-12 Bipolar disorder; CRC trans rs951252 0.504 rs11734405 chr4:146081096 C/T cg25798026 chr22:32149910 DEPDC5 0.44 6.22 0.32 1.49e-9 Hip circumference; CRC trans rs7580658 0.614 rs7585198 chr2:127962635 C/T cg01525597 chr12:1739061 WNT5B -0.44 -6.04 -0.32 4.26e-9 Protein C levels; CRC cis rs4819052 0.851 rs13048789 chr21:46660714 A/G cg02159808 chr21:46707872 POFUT2;LOC642852 0.49 6.41 0.33 5.19e-10 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs6502050 0.871 rs6502055 chr17:80070868 G/T cg09264619 chr17:80180166 NA 0.35 5.67 0.3 3.14e-8 Life satisfaction; CRC cis rs2067615 0.524 rs10778500 chr12:107074410 T/A cg15890332 chr12:107067104 RFX4 0.32 5.71 0.3 2.58e-8 Heart rate; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg17365369 chr19:52773256 ZNF766 0.41 6.5 0.34 2.96e-10 Liver disease severity in Alagille syndrome; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg12978357 chr2:114426529 NA -0.37 -6.25 -0.33 1.27e-9 Liver disease severity in Alagille syndrome; CRC cis rs3772130 0.962 rs11707504 chr3:121496734 C/T cg20356878 chr3:121714668 ILDR1 0.51 8.03 0.4 1.74e-14 Cognitive performance; CRC cis rs12497850 0.931 rs13315711 chr3:48986399 A/T cg07636037 chr3:49044803 WDR6 1.04 18.72 0.72 9.15e-54 Parkinson's disease; CRC cis rs13108904 0.846 rs12643212 chr4:1224948 A/G cg00684032 chr4:1343700 KIAA1530 0.47 7.04 0.36 1.12e-11 Obesity-related traits; CRC cis rs780096 0.565 rs10169261 chr2:27727314 C/T cg21248554 chr2:27665150 KRTCAP3 -0.32 -7.29 -0.37 2.31e-12 Total body bone mineral density; CRC cis rs10504229 0.679 rs7840100 chr8:58036662 T/G cg22535103 chr8:58192502 C8orf71 -0.44 -5.8 -0.3 1.55e-8 Developmental language disorder (linguistic errors); CRC cis rs4332037 0.624 rs11764337 chr7:1892309 A/G cg23422044 chr7:1970798 MAD1L1 0.5 6.59 0.34 1.74e-10 Bipolar disorder; CRC cis rs7258465 1.000 rs271624 chr19:18627953 A/G cg01065977 chr19:18549689 ISYNA1 -0.38 -5.83 -0.31 1.33e-8 Breast cancer; CRC cis rs1153858 1.000 rs4775906 chr15:45638294 C/T cg14582100 chr15:45693742 SPATA5L1 0.28 5.87 0.31 1.07e-8 Homoarginine levels; CRC cis rs977987 0.872 rs3743609 chr16:75467021 G/C cg03315344 chr16:75512273 CHST6 0.52 8.85 0.44 5.37e-17 Dupuytren's disease; CRC cis rs9393777 0.513 rs9393741 chr6:26654189 A/G cg12292205 chr6:26970375 C6orf41 -0.61 -6.99 -0.36 1.52e-11 Intelligence (multi-trait analysis); CRC cis rs427394 0.632 rs377137 chr5:6740468 T/G cg15145174 chr5:6755386 POLS -0.43 -6.29 -0.33 1.04e-9 Menopause (age at onset); CRC cis rs9837602 1.000 rs793496 chr3:99507254 T/C cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G -0.47 -5.62 -0.3 4.07e-8 Breast cancer; CRC cis rs910316 0.763 rs175036 chr14:75464295 C/T cg03030879 chr14:75389066 RPS6KL1 0.38 5.67 0.3 3.12e-8 Height; CRC cis rs2074585 0.583 rs28406958 chr15:91069364 C/A cg04176472 chr15:90893244 GABARAPL3 -0.36 -5.64 -0.3 3.72e-8 Basophil percentage of granulocytes;White blood cell count (basophil);Basophil percentage of white cells; CRC cis rs11123170 0.542 rs28522253 chr2:113967387 G/A cg11763394 chr2:113992921 PAX8;LOC440839;LOC654433 0.51 5.98 0.31 5.88e-9 Renal function-related traits (BUN); CRC cis rs1904096 0.506 rs4693381 chr4:95206855 A/T cg11021082 chr4:95130006 SMARCAD1 0.59 9.45 0.46 6.46e-19 Type 2 diabetes; CRC cis rs13108904 0.557 rs1680033 chr4:1243404 C/T cg20887711 chr4:1340912 KIAA1530 -0.63 -8.71 -0.43 1.5e-16 Obesity-related traits; CRC cis rs16924133 1.000 rs12293312 chr11:33224143 T/C cg05567920 chr11:33183001 CSTF3 -0.78 -6.08 -0.32 3.39e-9 Anger; CRC cis rs1799949 0.683 rs55737636 chr17:41264739 C/T cg05368731 chr17:41323189 NBR1 0.63 9.44 0.46 7.32e-19 Menopause (age at onset); CRC trans rs9291683 0.551 rs2240720 chr4:10020480 C/T cg26043149 chr18:55253948 FECH 0.51 7.92 0.4 3.79e-14 Bone mineral density; CRC cis rs10045504 0.502 rs17456198 chr5:38732005 A/G cg15396434 chr5:38725168 NA -0.59 -6.05 -0.32 3.88e-9 Night sleep phenotypes; CRC trans rs9545047 0.716 rs6563096 chr13:79858235 C/T cg07061582 chr15:90234082 PEX11A;WDR93 -0.42 -5.99 -0.31 5.41e-9 Schizophrenia; CRC cis rs4665809 0.590 rs1122972 chr2:26418788 A/C cg26119090 chr2:26468346 HADHA;HADHB -1.05 -15.29 -0.64 3.04e-40 Gut microbiome composition (summer); CRC cis rs2982552 0.805 rs2982557 chr6:152056369 G/A cg22157087 chr6:152012887 ESR1 0.37 5.81 0.3 1.48e-8 Bone properties (heel); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg26871885 chr11:207525 RIC8A;BET1L 0.43 7.03 0.36 1.21e-11 Liver disease severity in Alagille syndrome; CRC cis rs9522267 0.535 rs7326875 chr13:112236231 C/T cg26182253 chr13:112236782 NA 0.31 6.33 0.33 7.97e-10 Hepatitis; CRC cis rs6694672 1.000 rs6428385 chr1:197048391 C/T cg13682187 chr1:196946512 CFHR5 0.47 7.35 0.38 1.56e-12 Asthma; CRC cis rs9611565 0.694 rs5758324 chr22:41787950 G/T cg03806693 chr22:41940476 POLR3H -0.73 -9.98 -0.48 1.14e-20 Vitiligo; CRC cis rs6076065 0.548 rs1112818 chr20:23323936 G/A cg11657817 chr20:23433608 CST11 0.57 9.74 0.47 7.49e-20 Facial morphology (factor 15, philtrum width); CRC cis rs3091242 0.900 rs1883427 chr1:25744468 C/T cg20684491 chr1:25596433 NA 0.42 7.43 0.38 9.61e-13 Erythrocyte sedimentation rate; CRC cis rs548181 0.611 rs562599 chr11:125459951 A/C cg03464685 chr11:125439445 EI24 1.25 13.21 0.59 2.91e-32 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs7909074 1.000 rs6593447 chr10:45400235 G/A cg04218760 chr10:45406644 TMEM72 -0.35 -9.76 -0.47 6.27e-20 Mean corpuscular volume; CRC cis rs727479 0.502 rs2289105 chr15:51507508 C/T cg19946085 chr15:51559439 CYP19A1 0.28 5.69 0.3 2.88e-8 Estradiol levels; CRC cis rs73206853 0.563 rs73194051 chr12:111204186 T/C cg12870014 chr12:110450643 ANKRD13A 0.64 7.11 0.36 7.4e-12 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC cis rs10504229 0.906 rs113745779 chr8:58191301 C/G cg22535103 chr8:58192502 C8orf71 -0.82 -12.27 -0.56 9.63e-29 Developmental language disorder (linguistic errors); CRC cis rs875971 1.000 rs1182882 chr7:65562063 C/T cg00343986 chr7:65444356 GUSB -0.47 -6.92 -0.36 2.32e-11 Aortic root size; CRC cis rs11212617 1.000 rs660429 chr11:108181511 A/C cg01991180 chr11:108092276 ATM;NPAT 0.41 5.94 0.31 7.36e-9 Response to metformin in type 2 diabetes (glycemic); CRC cis rs11229555 0.645 rs12294062 chr11:58175603 G/T cg15696309 chr11:58395628 NA -0.81 -10.45 -0.5 2.9e-22 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; CRC trans rs10506458 0.915 rs12426017 chr12:63396272 T/G cg22491629 chr6:157744540 C6orf35 -0.77 -9.14 -0.45 6.45e-18 Hemostatic factors and hematological phenotypes; CRC cis rs2645694 0.533 rs2645681 chr4:77820949 G/A cg18351406 chr4:77819688 ANKRD56 0.5 7.53 0.38 5e-13 Emphysema distribution in smoking; CRC cis rs2836633 0.929 rs4514962 chr21:40041753 C/T cg12884169 chr21:40033163 ERG 0.43 9.8 0.48 4.55e-20 Coronary artery disease; CRC cis rs4631830 0.720 rs7090326 chr10:51503375 A/T cg20129853 chr10:51489980 NA -0.35 -5.81 -0.31 1.45e-8 Prostate-specific antigen levels; CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg05265988 chr5:180688748 TRIM52 0.39 6.56 0.34 2.1e-10 Obesity-related traits; CRC cis rs41005 0.967 rs6752776 chr2:8104594 A/G cg03155496 chr2:8117019 LOC339788 0.37 6.4 0.33 5.2400000000000005e-10 Response to anti-TNF therapy in rheumatoid arthritis; CRC cis rs2204008 0.837 rs73112346 chr12:38357606 C/T cg26384229 chr12:38710491 ALG10B 0.69 9.24 0.45 3.04e-18 Bladder cancer; CRC cis rs9322193 0.923 rs55849538 chr6:149956466 T/C cg13206674 chr6:150067644 NUP43 0.66 9.55 0.47 3.03e-19 Lung cancer; CRC cis rs3008870 1.000 rs2815370 chr1:67503727 A/G cg08660285 chr1:67390436 MIER1;WDR78 -1.03 -14.8 -0.63 2.37e-38 Lymphocyte percentage of white cells; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg20712274 chr19:9946111 PIN1 0.44 6.13 0.32 2.51e-9 Anxiety disorder; CRC cis rs7312933 0.558 rs11181422 chr12:42718552 G/A cg19980929 chr12:42632907 YAF2 -0.39 -5.9 -0.31 9.12e-9 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CRC cis rs9747201 0.832 rs4072580 chr17:80160337 A/C cg09264619 chr17:80180166 NA -0.5 -7.21 -0.37 3.98e-12 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs6901250 0.788 rs591794 chr6:117089018 G/A cg12892004 chr6:117198278 RFX6 0.4 6.3 0.33 9.71e-10 C-reactive protein levels; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg11351475 chr10:75545401 KIAA0913 0.4 6.51 0.34 2.84e-10 Liver disease severity in Alagille syndrome; CRC cis rs10504229 0.683 rs73605816 chr8:58117167 T/C cg04204079 chr8:58130323 NA -0.45 -5.78 -0.3 1.71e-8 Developmental language disorder (linguistic errors); CRC trans rs877282 1.000 rs12779159 chr10:772143 T/C cg22713356 chr15:30763199 NA 1.27 15.87 0.66 1.59e-42 Uric acid levels; CRC cis rs6565180 1.000 rs11863150 chr16:30385503 C/T cg17640201 chr16:30407289 ZNF48 0.81 14.55 0.63 2.18e-37 Tonsillectomy; CRC trans rs148734725 1 rs148734725 chr3:49406708 G/A cg21582582 chr3:182698605 DCUN1D1 -0.52 -6.61 -0.34 1.52e-10 Educational attainment (college completion); CRC cis rs9660992 0.573 rs7531256 chr1:205191202 T/G cg21643547 chr1:205240462 TMCC2 -0.38 -6.15 -0.32 2.19e-9 Mean corpuscular volume;Mean platelet volume; CRC cis rs8067545 0.611 rs9893832 chr17:20038273 A/G cg13482628 chr17:19912719 NA 0.43 6.75 0.35 6.5500000000000006e-11 Schizophrenia; CRC cis rs11098499 0.738 rs28408407 chr4:120376030 C/G cg09307838 chr4:120376055 NA 0.72 11.28 0.53 3.56e-25 Corneal astigmatism; CRC cis rs12142240 0.667 rs66990604 chr1:46822073 G/A cg14993813 chr1:46806288 NSUN4 -0.49 -6.22 -0.32 1.55e-9 Menopause (age at onset); CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg09995068 chr14:71288954 NA 0.45 6.13 0.32 2.57e-9 Anxiety disorder; CRC cis rs561341 1.000 rs546748 chr17:30324293 A/C cg23018236 chr17:30244563 NA -0.47 -6.63 -0.34 1.42e-10 Hip circumference adjusted for BMI; CRC cis rs10256972 0.621 rs10951594 chr7:1088607 C/G cg22907277 chr7:1156413 C7orf50 0.48 7.2 0.37 4.22e-12 Longevity;Endometriosis; CRC cis rs9916302 0.904 rs35335692 chr17:37710006 A/G cg15445000 chr17:37608096 MED1 0.42 9.4 0.46 9.89e-19 Glomerular filtration rate (creatinine); CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg22745781 chr7:16461244 ISPD 0.37 6.1 0.32 3e-9 Obesity-related traits; CRC cis rs8177253 0.763 rs6797713 chr3:133474832 T/C cg08048268 chr3:133502702 NA -0.33 -5.86 -0.31 1.15e-8 Iron status biomarkers; CRC cis rs929354 1.000 rs1182381 chr7:157043473 G/A cg16102536 chr7:156981717 UBE3C -0.39 -6.65 -0.34 1.24e-10 Body mass index; CRC cis rs2243480 0.908 rs4718273 chr7:65216099 G/A cg18252515 chr7:66147081 NA 1.11 12.73 0.57 1.93e-30 Diabetic kidney disease; CRC cis rs1552244 0.882 rs7633769 chr3:10020622 C/T cg08888203 chr3:10149979 C3orf24 0.6 8.42 0.42 1.22e-15 Alzheimer's disease; CRC cis rs1862618 0.713 rs832549 chr5:56183542 C/T cg18230493 chr5:56204884 C5orf35 -0.75 -9.27 -0.45 2.61e-18 Initial pursuit acceleration; CRC cis rs17345786 0.861 rs11707689 chr3:101086475 A/G cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.57 6.79 0.35 5.15e-11 Colonoscopy-negative controls vs population controls; CRC cis rs12476592 0.602 rs9789351 chr2:63740614 A/G cg10828910 chr2:63850056 LOC388955 0.48 5.93 0.31 7.6e-9 Childhood ear infection; CRC trans rs2303319 0.504 rs62189041 chr2:162599506 T/C cg20024234 chr21:43431083 ZNF295 -0.66 -5.99 -0.31 5.57e-9 Cognitive function; CRC cis rs6860806 0.631 rs7736284 chr5:131588151 T/C cg11843238 chr5:131593191 PDLIM4 0.43 8.21 0.41 5.02e-15 Breast cancer; CRC cis rs951366 0.789 rs823121 chr1:205724302 A/G cg07157834 chr1:205819609 PM20D1 -0.77 -11.74 -0.54 8.14e-27 Menarche (age at onset); CRC trans rs1814175 0.935 rs11040438 chr11:49622521 G/A cg15704280 chr7:45808275 SEPT13 -0.97 -18.03 -0.7 5.04e-51 Height; CRC cis rs950027 0.620 rs1153857 chr15:45659095 G/T cg10760299 chr15:45669010 GATM 0.36 5.66 0.3 3.25e-8 Response to fenofibrate (adiponectin levels); CRC cis rs9814567 1.000 rs2370641 chr3:134222161 A/C cg06541857 chr3:134203789 ANAPC13;CEP63 -0.41 -6.22 -0.32 1.48e-9 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs950169 1.000 rs1911155 chr15:84787635 A/G cg03959625 chr15:84868606 LOC388152 0.41 6.15 0.32 2.3e-9 Schizophrenia; CRC cis rs7394190 0.748 rs34163229 chr10:75406912 G/T cg07699608 chr10:75541558 CHCHD1 0.62 6.39 0.33 5.52e-10 Incident atrial fibrillation; CRC trans rs1814175 0.817 rs3974439 chr11:50022607 G/A cg15704280 chr7:45808275 SEPT13 -0.99 -20.61 -0.75 3.6e-61 Height; CRC cis rs12497850 0.864 rs12493001 chr3:49181885 A/G cg20833759 chr3:49053208 WDR6;DALRD3 0.45 7.29 0.37 2.32e-12 Parkinson's disease; CRC cis rs2115630 0.967 rs11073731 chr15:85355113 C/A cg11189052 chr15:85197271 WDR73 -0.57 -9.25 -0.45 3.01e-18 P wave terminal force; CRC cis rs2933343 0.630 rs75824035 chr3:128652985 T/C cg11901034 chr3:128598214 ACAD9 -0.57 -8.01 -0.4 1.99e-14 IgG glycosylation; CRC trans rs7395662 0.963 rs11039774 chr11:48513959 G/C cg21153622 chr11:89784906 NA -0.48 -7.72 -0.39 1.44e-13 HDL cholesterol; CRC cis rs2342406 0.825 rs1026062 chr2:45142078 G/A cg23424933 chr2:45157613 NA 0.43 5.71 0.3 2.57e-8 Myopia; CRC cis rs6456156 0.586 rs9459853 chr6:167465774 C/A cg07741184 chr6:167504864 NA 0.39 6.84 0.35 3.77e-11 Primary biliary cholangitis; CRC cis rs6500395 1.000 rs11859909 chr16:48668441 T/C cg04672837 chr16:48644449 N4BP1 0.45 6.73 0.35 7.64e-11 Response to tocilizumab in rheumatoid arthritis; CRC cis rs514406 0.760 rs1242198 chr1:53352016 G/A cg24675658 chr1:53192096 ZYG11B -0.62 -9.21 -0.45 3.88e-18 Monocyte count; CRC cis rs13064411 0.696 rs869342 chr3:113226330 C/T cg18753928 chr3:113234510 CCDC52 -0.7 -10.74 -0.51 2.89e-23 Response to simvastatin treatment (PCSK9 protein level change); CRC cis rs7772486 0.701 rs11155438 chr6:145950112 C/G cg13319975 chr6:146136371 FBXO30 -0.45 -6.56 -0.34 2.06e-10 Lobe attachment (rater-scored or self-reported); CRC trans rs559356 0.519 rs523810 chr3:34848023 G/A cg19071035 chr6:20404090 E2F3 0.47 6.29 0.33 1.04e-9 Cognitive function; CRC cis rs738322 0.935 rs2413503 chr22:38568944 A/T cg25457927 chr22:38595422 NA -0.36 -7.47 -0.38 7.23e-13 Cutaneous nevi; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg05972000 chr8:67525501 MYBL1 0.41 6.49 0.34 3.19e-10 Liver disease severity in Alagille syndrome; CRC cis rs7618915 0.570 rs11130312 chr3:52675055 A/C cg18099408 chr3:52552593 STAB1 -0.43 -7.08 -0.36 8.86e-12 Bipolar disorder; CRC cis rs17270561 0.887 rs717551 chr6:25855624 T/C cg16482183 chr6:26056742 HIST1H1C 0.89 10.03 0.48 7.97e-21 Iron status biomarkers; CRC cis rs1223397 0.651 rs2496147 chr6:13313233 C/T cg07912922 chr6:13274314 PHACTR1 0.38 5.93 0.31 7.79e-9 Blood pressure; CRC cis rs6089584 0.927 rs3787427 chr20:60579789 T/C cg06108461 chr20:60628389 TAF4 -0.71 -12.09 -0.55 4.33e-28 Body mass index; CRC cis rs12282928 1.000 rs1566730 chr11:48250854 G/A cg20307385 chr11:47447363 PSMC3 0.47 5.81 0.31 1.45e-8 Migraine - clinic-based; CRC cis rs17767392 0.957 rs7140354 chr14:71759616 C/A cg13720639 chr14:72061746 SIPA1L1 -0.53 -6.82 -0.35 4.34e-11 Mitral valve prolapse; CRC cis rs7680126 0.633 rs74469609 chr4:10294424 G/A cg11266682 chr4:10021025 SLC2A9 -0.43 -6.54 -0.34 2.39e-10 Urate levels in lean individuals;Urate levels in overweight individuals;Urate levels in obese individuals; CRC cis rs6504950 0.800 rs9900816 chr17:53012057 G/A cg26251398 chr17:52985966 TOM1L1 0.37 5.65 0.3 3.41e-8 Breast cancer; CRC cis rs9902453 0.967 rs56326816 chr17:28492805 C/T cg26525008 chr17:28256777 EFCAB5;SSH2 0.55 8.3 0.42 2.76e-15 Coffee consumption (cups per day); CRC cis rs863345 0.604 rs2054993 chr1:158505968 T/G cg12129480 chr1:158549410 OR10X1 -0.3 -6.25 -0.33 1.25e-9 Pneumococcal bacteremia; CRC cis rs1552244 0.882 rs2130813 chr3:10038706 A/C cg00166722 chr3:10149974 C3orf24 0.63 8.28 0.42 3.08e-15 Alzheimer's disease; CRC cis rs16975963 0.843 rs2382624 chr19:38419025 A/G cg15135657 chr19:38346511 NA -0.43 -5.75 -0.3 2.01e-8 Longevity; CRC cis rs2882667 0.931 rs10075039 chr5:138337854 A/G cg09476006 chr5:138032270 NA 0.44 7.29 0.37 2.32e-12 Age-related hearing impairment (SNP x SNP interaction); CRC trans rs11148252 0.574 rs73186430 chr13:53232891 T/C cg18335740 chr13:41363409 SLC25A15 0.79 14.44 0.62 6.18e-37 Lewy body disease; CRC cis rs9463078 0.774 rs4446571 chr6:45257662 T/C cg25276700 chr6:44698697 NA -0.27 -6.46 -0.34 3.81e-10 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; CRC cis rs7119 0.634 rs2667782 chr15:77862296 A/C cg27398640 chr15:77910606 LINGO1 0.43 7.3 0.37 2.21e-12 Type 2 diabetes; CRC cis rs5750830 0.649 rs5750808 chr22:39790987 G/A cg25956985 chr22:39795188 MAP3K7IP1 -0.47 -6.64 -0.34 1.28e-10 Intelligence (multi-trait analysis); CRC cis rs28493229 0.522 rs2233152 chr19:41281016 C/T cg21869046 chr19:41225005 ITPKC 0.57 8.0 0.4 2.1e-14 Kawasaki disease; CRC cis rs6066835 1.000 rs6063314 chr20:47353106 T/C cg18078177 chr20:47281410 PREX1 0.63 5.78 0.3 1.7e-8 Multiple myeloma; CRC cis rs10870270 1.000 rs10870232 chr10:133738537 T/G cg08754478 chr10:133766260 PPP2R2D -0.64 -9.26 -0.45 2.65e-18 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; CRC cis rs8031584 0.560 rs7171208 chr15:31198929 A/G cg14829155 chr15:31115871 NA 0.37 5.89 0.31 9.78e-9 Huntington's disease progression; CRC cis rs1448094 0.556 rs2061686 chr12:86170951 C/T cg19622623 chr12:86230825 RASSF9 0.37 5.89 0.31 9.4e-9 Major depressive disorder; CRC trans rs12195424 0.730 rs9475698 chr6:56298924 A/G cg12112058 chr1:224622605 WDR26 0.49 6.0 0.31 5.12e-9 Cerebrospinal fluid clusterin levels; CRC cis rs7927771 0.832 rs7924485 chr11:47419129 A/G cg20307385 chr11:47447363 PSMC3 0.64 9.29 0.46 2.1e-18 Subjective well-being; CRC cis rs1215050 0.791 rs592053 chr4:98732220 C/T cg05340658 chr4:99064831 C4orf37 0.46 6.86 0.35 3.48e-11 Waist-to-hip ratio adjusted for body mass index; CRC cis rs1862618 0.756 rs9292125 chr5:56107200 C/T cg03609598 chr5:56110824 MAP3K1 -0.84 -10.39 -0.5 4.83e-22 Initial pursuit acceleration; CRC cis rs10876993 0.680 rs2277322 chr12:58009202 T/C cg18357645 chr12:58087776 OS9 -0.49 -6.52 -0.34 2.64e-10 Celiac disease or Rheumatoid arthritis; CRC cis rs875971 0.825 rs6951503 chr7:65718936 T/G cg18252515 chr7:66147081 NA 0.42 5.85 0.31 1.19e-8 Aortic root size; CRC cis rs853679 0.517 rs34716816 chr6:28046169 C/A cg12172441 chr6:28176163 NA 0.59 7.12 0.37 6.82e-12 Depression; CRC cis rs4731207 0.596 rs13233978 chr7:124587620 G/A cg23710748 chr7:124431027 NA -0.38 -6.08 -0.32 3.35e-9 Cutaneous malignant melanoma; CRC cis rs6570726 0.559 rs11754523 chr6:145727951 A/G cg23711669 chr6:146136114 FBXO30 -0.47 -7.17 -0.37 4.86e-12 Lobe attachment (rater-scored or self-reported); CRC cis rs7072216 0.881 rs4345897 chr10:100147060 A/G cg26618903 chr10:100175079 PYROXD2 -0.37 -6.24 -0.33 1.37e-9 Metabolite levels; CRC cis rs61160187 0.582 rs3797559 chr5:60223741 A/G cg16298547 chr5:60138761 ELOVL7 -0.28 -5.94 -0.31 7.36e-9 Educational attainment (years of education);Educational attainment (college completion); CRC cis rs6674176 0.628 rs12145999 chr1:44428632 C/T cg15962314 chr1:44399869 ARTN 0.3 5.76 0.3 1.89e-8 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Cognitive ability; CRC trans rs11039798 0.778 rs7944523 chr11:48911019 G/A cg03929089 chr4:120376271 NA 0.64 6.1 0.32 2.95e-9 Axial length; CRC cis rs1997103 1.000 rs2177805 chr7:55404381 T/A cg17469321 chr7:55412551 NA 0.72 11.24 0.53 5.04e-25 QRS interval (sulfonylurea treatment interaction); CRC cis rs7953249 0.656 rs2243616 chr12:121406370 G/T cg02403541 chr12:121454288 C12orf43 -0.41 -5.89 -0.31 9.67e-9 Invasive epithelial ovarian cancer;High-grade serous ovarian cancer;Chronic obstructive pulmonary disease-related biomarkers;N-glycan levels;Serous invasive ovarian cancer;Epithelial ovarian cancer; CRC cis rs6598163 0.520 rs12813376 chr12:132302324 C/T cg07389463 chr12:132296394 NA 0.39 6.08 0.32 3.4e-9 Migraine; CRC cis rs951366 0.764 rs823143 chr1:205743425 A/C cg26354017 chr1:205819088 PM20D1 0.74 11.35 0.53 2.08e-25 Menarche (age at onset); CRC cis rs13108904 0.935 rs6853002 chr4:1295991 C/T cg24560729 chr4:1342394 KIAA1530 0.32 5.74 0.3 2.11e-8 Obesity-related traits; CRC cis rs9649213 0.593 rs6961438 chr7:98005849 T/C cg21770322 chr7:97807741 LMTK2 0.51 8.43 0.42 1.08e-15 Prostate cancer (SNP x SNP interaction); CRC cis rs6479527 0.904 rs2026917 chr9:96778644 C/T cg14459158 chr9:96720562 NA 0.39 6.97 0.36 1.69e-11 Esophageal adenocarcinoma; CRC cis rs4692589 0.743 rs3806825 chr4:170948619 T/C cg19918862 chr4:170955249 NA 0.5 7.83 0.4 6.76e-14 Anxiety disorder; CRC cis rs6534441 0.857 rs58568869 chr4:125459674 A/G cg21609808 chr4:125404261 NA 0.38 5.75 0.3 2.07e-8 Major depressive disorder; CRC cis rs13191362 0.507 rs1954810 chr6:163061749 C/T cg21926612 chr6:163149169 PACRG;PARK2 -0.6 -9.69 -0.47 1.08e-19 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs908922 0.887 rs4845783 chr1:152492559 G/A cg23254163 chr1:152506842 NA 0.42 7.18 0.37 4.7e-12 Hair morphology; CRC cis rs2204008 0.687 rs1733404 chr12:38123395 G/T cg13010199 chr12:38710504 ALG10B -0.44 -5.95 -0.31 6.94e-9 Bladder cancer; CRC cis rs10504229 0.683 rs59528137 chr8:58138565 C/T cg24829409 chr8:58192753 C8orf71 -0.68 -8.5 -0.42 6.62e-16 Developmental language disorder (linguistic errors); CRC trans rs875971 0.660 rs2191268 chr7:66110224 C/T ch.1.183610071R chr1:185343448 NA -0.41 -6.29 -0.33 1.01e-9 Aortic root size; CRC cis rs9399135 0.967 rs11754783 chr6:135347661 T/A cg22676075 chr6:135203613 NA 0.41 6.38 0.33 5.97e-10 Red blood cell count; CRC cis rs11628318 0.570 rs4906231 chr14:103062227 T/C cg23461800 chr14:103021989 NA -0.68 -7.83 -0.4 6.62e-14 Platelet count; CRC cis rs2228479 0.764 rs7186976 chr16:89961593 A/G cg06656553 chr16:89960601 TCF25 -0.56 -5.7 -0.3 2.62e-8 Skin colour saturation; CRC cis rs796364 1.000 rs4410273 chr2:200818258 T/C cg23649088 chr2:200775458 C2orf69 0.57 6.01 0.31 4.95e-9 Schizophrenia; CRC cis rs13191362 0.938 rs35395472 chr6:163008493 G/A cg21926612 chr6:163149169 PACRG;PARK2 0.78 10.8 0.51 1.77e-23 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs6952808 0.929 rs1801368 chr7:1976457 C/T cg02951883 chr7:2050386 MAD1L1 -0.7 -10.65 -0.51 5.99e-23 Bipolar disorder and schizophrenia; CRC cis rs2721195 0.549 rs2958492 chr8:145919126 C/T cg15320075 chr8:145703422 NA 0.42 6.52 0.34 2.63e-10 Age at first birth; CRC cis rs4713118 0.662 rs13218430 chr6:28029837 T/C cg02683197 chr6:28174875 NA 0.75 9.78 0.47 5.25e-20 Parkinson's disease; CRC cis rs2239547 0.603 rs34230854 chr3:53078590 C/A cg11645453 chr3:52864694 ITIH4 0.51 8.38 0.42 1.55e-15 Schizophrenia; CRC cis rs6088590 1.000 rs6088590 chr20:33313566 T/C cg08999081 chr20:33150536 PIGU 0.49 8.42 0.42 1.18e-15 Coronary artery disease; CRC cis rs6964587 0.692 rs12536220 chr7:91805595 T/G cg17063962 chr7:91808500 NA 0.62 10.1 0.49 4.48e-21 Breast cancer; CRC trans rs11098499 0.722 rs10006192 chr4:120263022 T/C cg25214090 chr10:38739885 LOC399744 0.54 8.65 0.43 2.34e-16 Corneal astigmatism; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg12814969 chr4:83934274 LIN54 0.46 6.03 0.32 4.38e-9 Anxiety disorder; CRC cis rs12950390 0.893 rs72831644 chr17:45824391 T/C cg24803719 chr17:45855879 NA -0.33 -7.1 -0.36 7.79e-12 IgG glycosylation; CRC cis rs2880765 0.714 rs6497187 chr15:86011350 A/G cg17133734 chr15:86042851 AKAP13 0.4 6.35 0.33 6.95e-10 Coronary artery disease; CRC cis rs56146971 0.670 rs12590074 chr14:91867390 T/G cg16433844 chr14:91963127 SMEK1 -0.53 -5.65 -0.3 3.41e-8 Alzheimer disease and age of onset; CRC cis rs7412746 0.658 rs11204739 chr1:150865760 A/G cg17724175 chr1:150552817 MCL1 0.45 6.73 0.35 7.67e-11 Melanoma; CRC cis rs12586317 0.547 rs28577270 chr14:35498443 G/A cg16230307 chr14:35515116 FAM177A1 0.9 10.55 0.5 1.36e-22 Psoriasis; CRC cis rs11190604 1.000 rs7070776 chr10:102264672 A/G cg07080220 chr10:102295463 HIF1AN 0.46 5.76 0.3 1.93e-8 Palmitoleic acid (16:1n-7) levels; CRC cis rs9322193 0.923 rs2297932 chr6:150039361 C/G cg05861140 chr6:150128134 PCMT1 -0.36 -5.85 -0.31 1.18e-8 Lung cancer; CRC cis rs344364 0.511 rs2917519 chr16:1950479 C/A cg00046913 chr16:1877150 HAGH;FAHD1 -0.57 -5.98 -0.31 5.7e-9 Glomerular filtration rate in chronic kidney disease; CRC cis rs3806843 0.868 rs2531345 chr5:140126781 T/G cg16607685 chr5:140181889 PCDHA2;PCDHA1;PCDHA3 0.26 5.93 0.31 7.73e-9 Depressive symptoms (multi-trait analysis); CRC cis rs6032067 0.929 rs17424696 chr20:43810734 G/A cg10761708 chr20:43804764 PI3 0.5 5.78 0.3 1.78e-8 Blood protein levels; CRC cis rs4665809 0.590 rs13387855 chr2:26420708 T/G cg22920501 chr2:26401640 FAM59B -0.82 -11.68 -0.54 1.37e-26 Gut microbiome composition (summer); CRC cis rs9393692 0.645 rs9467703 chr6:26318903 A/G cg13736514 chr6:26305472 NA -0.65 -11.5 -0.54 5.99e-26 Educational attainment; CRC cis rs72772090 0.539 rs11749811 chr5:96115925 C/T cg17330273 chr5:96107758 CAST;ERAP1 -0.67 -6.13 -0.32 2.49e-9 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs4363385 0.818 rs1048296 chr1:153012240 A/C cg25856811 chr1:152973957 SPRR3 -0.25 -6.99 -0.36 1.51e-11 Inflammatory skin disease; CRC cis rs4285028 0.948 rs6790281 chr3:121665543 C/A cg11130432 chr3:121712080 ILDR1 -0.48 -6.2 -0.32 1.66e-9 Multiple sclerosis; CRC cis rs2075371 0.829 rs35897242 chr7:134004041 G/A cg20476274 chr7:133979776 SLC35B4 0.68 11.23 0.53 5.29e-25 Mean platelet volume; CRC cis rs9807989 0.507 rs6745614 chr2:102991213 A/G cg03938978 chr2:103052716 IL18RAP 0.59 10.24 0.49 1.48e-21 Asthma; CRC cis rs13108904 0.934 rs13125842 chr4:1280947 G/A cg16405210 chr4:1374714 KIAA1530 -0.44 -6.03 -0.32 4.36e-9 Obesity-related traits; CRC cis rs2243480 1.000 rs2707831 chr7:66062511 G/A cg25985355 chr7:65971099 NA -0.52 -5.97 -0.31 6.08e-9 Diabetic kidney disease; CRC cis rs7626444 0.625 rs1798635 chr3:196474289 C/T cg12930392 chr3:196481615 PAK2 0.4 7.05 0.36 1.07e-11 Monocyte count; CRC cis rs1218582 0.804 rs4845398 chr1:154859038 G/C cg16680214 chr1:154839983 KCNN3 -0.48 -9.45 -0.46 6.56e-19 Prostate cancer; CRC cis rs3617 0.625 rs11719137 chr3:52876389 G/T cg15147215 chr3:52552868 STAB1 0.51 8.91 0.44 3.5e-17 Red blood cell count;Autism spectrum disorder or schizophrenia; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg18907495 chr17:53828548 PCTP 0.42 5.98 0.31 5.92e-9 Response to antipsychotic treatment; CRC cis rs7647973 1.000 rs1009051 chr3:49521549 G/A cg07690219 chr3:49449608 TCTA;RHOA -0.53 -6.13 -0.32 2.56e-9 Menarche (age at onset); CRC cis rs16975963 0.644 rs73031326 chr19:38043022 G/T cg15135657 chr19:38346511 NA -0.45 -6.25 -0.33 1.25e-9 Longevity; CRC cis rs6951245 1.000 rs76214082 chr7:1102097 T/A cg03188948 chr7:1209495 NA 0.65 6.84 0.35 3.8e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs10992471 0.630 rs10453241 chr9:95198887 C/A cg13798575 chr9:95087839 CENPP;NOL8 -0.41 -6.15 -0.32 2.31e-9 Visceral adipose tissue/subcutaneous adipose tissue ratio; CRC cis rs992157 0.798 rs7587220 chr2:219160864 C/A cg13835894 chr2:219148914 PNKD;TMBIM1 -0.34 -6.45 -0.34 3.94e-10 Colorectal cancer; CRC cis rs2762353 0.718 rs1165205 chr6:25870542 A/T cg03517284 chr6:25882590 NA 0.49 7.43 0.38 9.59e-13 Blood metabolite levels; CRC cis rs10504229 0.639 rs16921812 chr8:58106737 C/T cg22535103 chr8:58192502 C8orf71 -0.69 -8.8 -0.44 7.79e-17 Developmental language disorder (linguistic errors); CRC cis rs7605827 0.930 rs9287663 chr2:15596076 T/G cg19274914 chr2:15703543 NA 0.39 5.9 0.31 9.14e-9 Educational attainment (years of education); CRC cis rs7809950 0.723 rs2237662 chr7:106874065 C/G cg23024343 chr7:107201750 COG5 -0.72 -9.47 -0.46 5.67e-19 Coronary artery disease; CRC cis rs13108904 0.840 rs13149790 chr4:1262239 A/G cg02018176 chr4:1364513 KIAA1530 0.45 7.43 0.38 9.46e-13 Obesity-related traits; CRC cis rs7731657 0.537 rs7709977 chr5:130367086 A/T cg08523029 chr5:130500466 HINT1 -0.46 -5.98 -0.31 5.75e-9 Fasting plasma glucose; CRC cis rs4713118 0.869 rs7773070 chr6:27728827 T/C cg12273811 chr6:28175739 NA 0.55 7.84 0.4 6.19e-14 Parkinson's disease; CRC cis rs951366 0.903 rs823114 chr1:205719532 G/A cg14159672 chr1:205819179 PM20D1 0.44 6.48 0.34 3.41e-10 Menarche (age at onset); CRC cis rs9311474 0.507 rs6787154 chr3:52784416 C/T cg05573699 chr3:52720067 GNL3;PBRM1 -0.47 -6.81 -0.35 4.67e-11 Electroencephalogram traits; CRC cis rs10504229 0.593 rs16921589 chr8:58024387 C/A cg22535103 chr8:58192502 C8orf71 -0.53 -6.32 -0.33 8.44e-10 Developmental language disorder (linguistic errors); CRC cis rs763014 0.593 rs28455838 chr16:681966 T/C cg07343612 chr16:622815 PIGQ -0.78 -12.76 -0.58 1.43e-30 Height; CRC cis rs637571 0.522 rs493899 chr11:65747952 A/C cg17985854 chr11:65770987 BANF1;EIF1AD 0.51 8.68 0.43 1.82e-16 Eosinophil percentage of white cells; CRC cis rs733592 0.507 rs56129148 chr12:48485530 T/C cg21466736 chr12:48725269 NA 0.5 7.9 0.4 4.09e-14 Plateletcrit; CRC cis rs7208859 0.673 rs450585 chr17:28951039 G/A cg14008862 chr17:28927542 LRRC37B2 0.52 6.34 0.33 7.68e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs6952808 1.000 rs4601204 chr7:1890925 C/T cg20295408 chr7:1910781 MAD1L1 -0.43 -5.98 -0.31 5.97e-9 Bipolar disorder and schizophrenia; CRC cis rs7312933 0.670 rs10880258 chr12:42547531 C/T cg19980929 chr12:42632907 YAF2 0.44 6.54 0.34 2.32e-10 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CRC cis rs3785574 0.582 rs62072238 chr17:61948841 A/T cg06873352 chr17:61820015 STRADA 0.46 7.45 0.38 8.18e-13 Height; CRC cis rs2732480 0.500 rs11168468 chr12:48612465 C/T cg24011408 chr12:48396354 COL2A1 0.44 6.22 0.32 1.48e-9 Hemoglobin concentration;Red blood cell count;Hematocrit; CRC cis rs6582630 0.519 rs11181526 chr12:38360230 A/G cg26384229 chr12:38710491 ALG10B 0.68 9.75 0.47 6.92e-20 Drug-induced liver injury (flucloxacillin); CRC cis rs7772486 0.654 rs6906402 chr6:146089307 C/G cg05347473 chr6:146136440 FBXO30 -0.38 -5.67 -0.3 3.17e-8 Lobe attachment (rater-scored or self-reported); CRC trans rs916888 0.821 rs199505 chr17:44859410 A/G cg23590916 chr17:43697445 MGC57346 -0.57 -6.14 -0.32 2.32e-9 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs3857067 1.000 rs7694820 chr4:95017026 G/A cg11021082 chr4:95130006 SMARCAD1 -0.4 -6.06 -0.32 3.63e-9 QT interval; CRC cis rs1865760 0.534 rs1541988 chr6:25950804 C/A cg03517284 chr6:25882590 NA -0.41 -6.02 -0.32 4.56e-9 Height; CRC trans rs9929218 1.000 rs28549017 chr16:68758828 G/C cg04657470 chr2:198365150 HSPE1;HSPD1 -0.96 -13.8 -0.61 1.76e-34 Colorectal cancer; CRC cis rs7772486 0.754 rs4896839 chr6:146019689 T/G cg13319975 chr6:146136371 FBXO30 0.47 6.96 0.36 1.83e-11 Lobe attachment (rater-scored or self-reported); CRC cis rs4919694 0.901 rs79331374 chr10:104882913 G/A cg04362960 chr10:104952993 NT5C2 1.17 10.55 0.5 1.35e-22 Arsenic metabolism; CRC cis rs4555082 0.834 rs2816652 chr14:105712493 C/T cg06808227 chr14:105710500 BRF1 -0.62 -9.09 -0.45 9.84e-18 Mean platelet volume;Platelet distribution width; CRC cis rs9326248 0.539 rs7120565 chr11:117042949 T/C cg15534755 chr11:117069859 TAGLN 0.3 5.85 0.31 1.21e-8 Blood protein levels; CRC cis rs926392 0.547 rs8118808 chr20:37674996 C/G cg16355469 chr20:37678765 NA 0.47 6.94 0.36 2.14e-11 Dialysis-related mortality; CRC cis rs7412746 0.611 rs11204726 chr1:150743492 T/C cg10589385 chr1:150898437 SETDB1 0.3 6.08 0.32 3.34e-9 Melanoma; CRC cis rs4604732 0.536 rs78019731 chr1:247626430 C/T cg12758973 chr1:247694275 LOC148824;OR2C3 0.42 6.14 0.32 2.32e-9 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CRC cis rs62432291 0.681 rs2501177 chr6:159655593 C/T cg14500486 chr6:159655392 FNDC1 -0.76 -10.4 -0.5 4.17e-22 Joint mobility (Beighton score); CRC cis rs4862750 0.872 rs6825289 chr4:187879109 T/G cg11301795 chr4:187892539 NA -0.85 -19.37 -0.73 2.52e-56 Lobe attachment (rater-scored or self-reported); CRC cis rs11690935 0.921 rs6710698 chr2:172596078 G/C cg13550731 chr2:172543902 DYNC1I2 -1.07 -18.72 -0.72 9.51e-54 Schizophrenia; CRC cis rs11628318 0.713 rs1998419 chr14:103050397 C/G cg12046867 chr14:103022105 NA -0.82 -11.41 -0.53 1.25e-25 Platelet count; CRC cis rs56283067 0.887 rs62437968 chr6:44729495 G/A cg18551225 chr6:44695536 NA -0.42 -5.87 -0.31 1.08e-8 Total body bone mineral density; CRC cis rs8008758 1.000 rs12435364 chr14:101690209 G/A cg26224664 chr14:101693935 NA -0.4 -6.08 -0.32 3.36e-9 Body mass index (alcohol intake interaction); CRC cis rs780096 0.506 rs1647286 chr2:27714517 A/T cg24768116 chr2:27665128 KRTCAP3 -0.38 -8.69 -0.43 1.69e-16 Total body bone mineral density; CRC cis rs4665809 0.590 rs2384361 chr2:26452209 T/C cg27170947 chr2:26402098 FAM59B -0.6 -7.73 -0.39 1.32e-13 Gut microbiome composition (summer); CRC cis rs8031584 0.541 rs1983459 chr15:31208749 C/T cg14829155 chr15:31115871 NA -0.35 -5.68 -0.3 2.92e-8 Huntington's disease progression; CRC cis rs9733 0.596 rs6661872 chr1:150628357 C/G cg17724175 chr1:150552817 MCL1 0.58 9.4 0.46 9.25e-19 Tonsillectomy; CRC cis rs62064224 0.614 rs4794923 chr17:30763009 G/A cg25809561 chr17:30822961 MYO1D 0.56 10.11 0.49 4.22e-21 Schizophrenia; CRC cis rs916888 0.821 rs199512 chr17:44857352 T/C cg17911788 chr17:44343683 NA 0.56 6.86 0.35 3.4e-11 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs1577917 0.538 rs6454483 chr6:86418283 A/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A 0.59 8.52 0.43 5.67e-16 Response to antipsychotic treatment; CRC cis rs1472147 0.696 rs1532222 chr7:128516945 A/C cg00260937 chr7:128520193 KCP -0.46 -7.01 -0.36 1.35e-11 Calcium levels; CRC cis rs1348850 0.668 rs4893971 chr2:178495743 T/C cg22681709 chr2:178499509 PDE11A -0.35 -5.83 -0.31 1.33e-8 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs6427508 1 rs6427508 chr1:160238857 T/C cg02974968 chr1:160236444 NA -0.57 -9.02 -0.45 1.54e-17 Breast size; CRC cis rs13256369 1.000 rs9329165 chr8:8576642 C/T cg17143192 chr8:8559678 CLDN23 -0.5 -6.63 -0.34 1.39e-10 Obesity-related traits; CRC cis rs7619708 1 rs7619708 chr3:195810187 T/C cg00031303 chr3:195681400 NA -0.47 -5.6 -0.3 4.5e-8 Red cell distribution width; CRC cis rs9309473 1.000 rs11674602 chr2:73723185 A/T cg20560298 chr2:73613845 ALMS1 -0.48 -5.87 -0.31 1.05e-8 Metabolite levels; CRC cis rs902774 0.530 rs12819597 chr12:53353956 T/C cg16329197 chr12:53359506 NA -1.05 -10.11 -0.49 4.31e-21 Prostate cancer; CRC cis rs1552244 0.510 rs13075308 chr3:10034925 G/C cg02579736 chr3:10068473 FANCD2;CIDECP 0.93 12.04 0.55 6.69e-28 Alzheimer's disease; CRC cis rs3768617 0.510 rs4651143 chr1:183097398 A/G ch.1.3577855R chr1:183094577 LAMC1 0.88 15.3 0.64 2.7e-40 Fuchs's corneal dystrophy; CRC trans rs459571 0.959 rs416390 chr9:136908549 C/G cg15028160 chr19:49622717 PPFIA3;C19orf73 0.55 6.85 0.35 3.72e-11 Platelet distribution width; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg22345911 chr17:80231263 CSNK1D 0.32 6.36 0.33 6.74e-10 Liver disease severity in Alagille syndrome; CRC cis rs1577917 0.958 rs1591438 chr6:86525214 G/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.55 -6.85 -0.35 3.59e-11 Response to antipsychotic treatment; CRC cis rs10751667 0.643 rs7396767 chr11:938808 G/A cg01483505 chr11:975446 AP2A2 0.42 6.71 0.35 8.38e-11 Alzheimer's disease (late onset); CRC cis rs7216064 1.000 rs58551145 chr17:65837235 A/G cg12091567 chr17:66097778 LOC651250 -0.66 -7.42 -0.38 9.77e-13 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CRC cis rs17331151 0.573 rs77223362 chr3:52865125 G/A cg06204229 chr3:52865917 ITIH4 0.58 7.91 0.4 3.9e-14 Immune reponse to smallpox (secreted IL-2); CRC cis rs877282 0.898 rs11253348 chr10:765852 C/T cg06581033 chr10:766294 NA -0.53 -5.79 -0.3 1.61e-8 Uric acid levels; CRC cis rs6502050 0.835 rs9900072 chr17:80114360 C/G cg11859384 chr17:80120422 CCDC57 -0.37 -5.96 -0.31 6.44e-9 Life satisfaction; CRC cis rs561341 1.000 rs550264 chr17:30317540 G/T cg12193833 chr17:30244370 NA -0.76 -8.87 -0.44 4.62e-17 Hip circumference adjusted for BMI; CRC cis rs7618501 0.633 rs4688758 chr3:50028385 G/A cg24110177 chr3:50126178 RBM5 -0.47 -7.02 -0.36 1.26e-11 Intelligence (multi-trait analysis); CRC cis rs9649465 1.000 rs4588795 chr7:123349924 A/G cg03229431 chr7:123269106 ASB15 0.36 5.61 0.3 4.34e-8 Migraine; CRC cis rs6831352 0.879 rs29001196 chr4:100054116 C/T cg13256891 chr4:100009986 ADH5 -0.66 -8.89 -0.44 4.04e-17 Alcohol dependence; CRC cis rs7590720 1.000 rs4674048 chr2:216900023 G/A cg12620499 chr2:216877984 MREG 0.86 14.22 0.62 4.14e-36 Alcohol dependence; CRC cis rs4780401 0.609 rs7205994 chr16:11815964 C/T cg01061890 chr16:11836724 TXNDC11 -0.62 -9.25 -0.45 2.96e-18 Rheumatoid arthritis; CRC cis rs6545883 0.507 rs2442025 chr2:61571445 G/A cg10580144 chr2:61372316 C2orf74 -0.35 -7.81 -0.4 7.8500000000000006e-14 Tuberculosis; CRC cis rs10028773 0.700 rs7690338 chr4:120256468 C/G cg09307838 chr4:120376055 NA 0.62 9.63 0.47 1.68e-19 Educational attainment; CRC cis rs7208859 0.673 rs9915963 chr17:29019643 C/T cg13385521 chr17:29058706 SUZ12P 0.59 7.23 0.37 3.39e-12 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs40363 0.645 rs250630 chr16:3524242 C/T cg22508957 chr16:3507546 NAT15 0.6 9.31 0.46 1.81e-18 Tuberculosis; CRC cis rs853679 0.517 rs9380047 chr6:28037893 G/T cg12172441 chr6:28176163 NA 0.6 7.21 0.37 3.76e-12 Depression; CRC cis rs1129187 0.755 rs9471985 chr6:42941324 T/C cg26304593 chr6:42947056 PEX6 -0.45 -6.53 -0.34 2.47e-10 Alzheimer's disease in APOE e4+ carriers; CRC cis rs243505 0.767 rs243530 chr7:148412618 T/C cg09806900 chr7:148480153 CUL1 -0.46 -5.91 -0.31 8.78e-9 Inflammatory bowel disease;Crohn's disease; CRC cis rs4803455 0.565 rs1025497 chr19:41871254 A/G cg08477640 chr19:41863820 B9D2 0.46 7.02 0.36 1.26e-11 Migraine;Coronary artery disease; CRC cis rs1865760 0.964 rs9379802 chr6:25933898 T/A cg17691542 chr6:26056736 HIST1H1C 0.53 7.71 0.39 1.54e-13 Height; CRC cis rs1862618 0.853 rs832568 chr5:56153776 G/A cg03609598 chr5:56110824 MAP3K1 -0.83 -9.93 -0.48 1.68e-20 Initial pursuit acceleration; CRC cis rs7208859 0.623 rs55638872 chr17:29149552 G/C cg01831904 chr17:28903510 LRRC37B2 -0.66 -6.7 -0.35 9.13e-11 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs7666738 0.791 rs6828752 chr4:99063382 C/T cg05340658 chr4:99064831 C4orf37 0.6 9.38 0.46 1.1e-18 Colonoscopy-negative controls vs population controls; CRC cis rs35146811 0.625 rs858514 chr7:99825748 A/G cg13334819 chr7:99746414 C7orf59 0.59 7.53 0.38 4.99e-13 Coronary artery disease; CRC cis rs5769765 0.862 rs9616381 chr22:50312382 G/A cg22709217 chr22:50311962 ALG12;CRELD2 -1.12 -18.26 -0.71 6.49e-52 Schizophrenia; CRC cis rs7208859 0.673 rs423151 chr17:28952286 A/G cg26176469 chr17:28951361 LRRC37B2 0.5 5.9 0.31 9.06e-9 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs9368481 0.761 rs3931464 chr6:26939856 C/A cg05192639 chr6:26864778 GUSBL1 0.34 6.21 0.32 1.59e-9 Autism spectrum disorder or schizophrenia; CRC cis rs4665809 0.549 rs17527979 chr2:26428132 A/G cg04944784 chr2:26401820 FAM59B -0.87 -10.46 -0.5 2.68e-22 Gut microbiome composition (summer); CRC cis rs1046896 1.000 rs1046896 chr17:80685533 A/G cg02711726 chr17:80685570 FN3KRP 0.59 9.52 0.46 3.73e-19 Glycated hemoglobin levels; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg26294578 chr17:79319535 NA 0.46 6.62 0.34 1.45e-10 Response to antipsychotic treatment; CRC cis rs13108904 0.870 rs13124876 chr4:1247955 T/C cg00684032 chr4:1343700 KIAA1530 0.46 6.89 0.36 2.83e-11 Obesity-related traits; CRC cis rs8077889 0.956 rs58242860 chr17:41847300 T/C cg26893861 chr17:41843967 DUSP3 0.89 12.86 0.58 5.87e-31 Triglycerides; CRC cis rs4713118 0.911 rs9295746 chr6:27730064 T/C cg15786705 chr6:28176104 NA 0.58 7.07 0.36 9.12e-12 Parkinson's disease; CRC cis rs7945705 0.902 rs11042152 chr11:9020987 C/T cg00186954 chr11:8933980 ST5;C11orf17 0.42 6.55 0.34 2.25e-10 Hemoglobin concentration; CRC cis rs10504229 0.595 rs77615399 chr8:58117394 C/G cg21724239 chr8:58056113 NA 0.49 6.81 0.35 4.75e-11 Developmental language disorder (linguistic errors); CRC cis rs6952808 0.792 rs12537914 chr7:1948359 C/T cg20295408 chr7:1910781 MAD1L1 -0.43 -5.93 -0.31 7.62e-9 Bipolar disorder and schizophrenia; CRC cis rs4466137 0.953 rs974023 chr5:83014848 T/C cg15083037 chr5:83017644 HAPLN1 -0.53 -6.89 -0.36 2.82e-11 Prostate cancer; CRC cis rs6460942 0.841 rs6968277 chr7:12443795 C/A cg02935154 chr7:12443704 VWDE -0.43 -6.05 -0.32 3.88e-9 Coronary artery disease; CRC cis rs9399135 0.967 rs4451151 chr6:135310546 C/T cg24558204 chr6:135376177 HBS1L 0.5 7.93 0.4 3.46e-14 Red blood cell count; CRC cis rs4819052 0.851 rs2838864 chr21:46711474 A/T cg02159808 chr21:46707872 POFUT2;LOC642852 -0.5 -6.7 -0.35 9.24e-11 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg22388943 chr14:103799756 EIF5 0.42 5.98 0.31 5.92e-9 Response to antipsychotic treatment; CRC cis rs6502050 0.637 rs74765203 chr17:80118223 A/G cg19223190 chr17:80058835 NA 0.39 6.25 0.33 1.24e-9 Life satisfaction; CRC cis rs3087591 0.683 rs10512434 chr17:29639590 A/G cg24425628 chr17:29625626 OMG;NF1 -0.72 -13.36 -0.59 7.88e-33 Hip circumference; CRC trans rs6788895 1.000 rs6769917 chr3:150509604 A/T cg12790874 chr13:100310405 CLYBL 0.64 6.21 0.32 1.58e-9 Breast cancer; CRC cis rs801193 0.591 rs721717 chr7:66130292 G/T cg11764359 chr7:65958608 NA -0.59 -8.69 -0.43 1.7e-16 Aortic root size; CRC cis rs116095464 0.558 rs1812843 chr5:267658 A/G cg22857025 chr5:266934 NA -1.26 -17.0 -0.68 5.78e-47 Breast cancer; CRC cis rs1448094 0.717 rs7298614 chr12:86296513 C/T cg18827107 chr12:86230957 RASSF9 -0.46 -7.56 -0.38 4.04e-13 Major depressive disorder; CRC cis rs2732480 0.537 rs1061986 chr12:48736439 T/C cg04545296 chr12:48745243 ZNF641 0.36 6.22 0.32 1.49e-9 Hemoglobin concentration;Red blood cell count;Hematocrit; CRC cis rs3091242 0.933 rs34006994 chr1:25780668 C/T cg20684491 chr1:25596433 NA -0.43 -7.39 -0.38 1.23e-12 Erythrocyte sedimentation rate; CRC cis rs6496044 0.568 rs10468112 chr15:86073424 G/C cg17133734 chr15:86042851 AKAP13 0.39 6.34 0.33 7.6e-10 Interstitial lung disease; CRC cis rs11758351 1.000 rs80095925 chr6:26184942 C/T cg16070018 chr6:26224392 HIST1H3E 0.6 5.83 0.31 1.32e-8 Gout;Renal underexcretion gout; CRC cis rs9479482 0.967 rs3860823 chr6:150356526 A/G cg25797454 chr6:150327115 RAET1K 0.36 6.49 0.34 3.1e-10 Alopecia areata; CRC cis rs274567 0.550 rs272885 chr5:131667736 A/G cg18301423 chr5:131593218 PDLIM4 0.38 6.34 0.33 7.44e-10 Blood metabolite levels; CRC cis rs7949030 0.626 rs7943191 chr11:62328551 A/G cg13298116 chr11:62369859 EML3;MTA2 0.61 10.84 0.51 1.3e-23 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; CRC cis rs2274273 0.624 rs3783651 chr14:55850973 G/C cg10130446 chr14:55658398 DLGAP5 -0.43 -5.91 -0.31 8.32e-9 Protein biomarker; CRC cis rs8060686 0.565 rs55857142 chr16:68236741 A/T cg08314208 chr16:67682810 RLTPR -0.54 -5.92 -0.31 7.89e-9 HDL cholesterol;Metabolic syndrome; CRC trans rs35110281 0.693 rs2251253 chr21:45092257 T/A cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.4 6.55 0.34 2.26e-10 Mean corpuscular volume; CRC cis rs274567 0.501 rs581968 chr5:131710202 G/A cg27615366 chr5:131592974 PDLIM4 -0.32 -5.69 -0.3 2.77e-8 Blood metabolite levels; CRC cis rs11785693 0.862 rs73189843 chr8:5000915 C/T cg26367366 chr8:4980734 NA 0.74 9.01 0.45 1.65e-17 Neuroticism (multi-trait analysis);Neuroticism; CRC cis rs344364 0.511 rs1742472 chr16:1953040 A/G cg03013636 chr16:1946785 NA 0.53 6.71 0.35 8.34e-11 Glomerular filtration rate in chronic kidney disease; CRC trans rs10838798 0.504 rs11039634 chr11:48297843 A/G cg15704280 chr7:45808275 SEPT13 -0.48 -6.77 -0.35 5.89e-11 Height; CRC cis rs2180341 1.000 rs9375499 chr6:127618072 T/C cg27446573 chr6:127587934 RNF146 0.99 14.76 0.63 3.48e-38 Breast cancer; CRC cis rs9905704 0.918 rs385793 chr17:56730593 G/A cg12560992 chr17:57184187 TRIM37 0.56 7.63 0.39 2.5e-13 Testicular germ cell tumor; CRC cis rs17152411 1.000 rs7077936 chr10:126650065 C/T cg07906193 chr10:126599966 NA 0.61 6.81 0.35 4.73e-11 Height; CRC trans rs8002861 0.664 rs9567292 chr13:44444816 A/G cg12856521 chr11:46389249 DGKZ 0.44 7.08 0.36 8.9e-12 Leprosy; CRC trans rs208520 1.000 rs208536 chr6:66963440 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.89 -11.02 -0.52 2.96e-24 Exhaled nitric oxide output; CRC cis rs56235845 0.694 rs4532376 chr5:176774403 G/A cg16006841 chr5:176797999 RGS14 0.54 8.72 0.43 1.38e-16 Hemoglobin concentration;Hematocrit; CRC cis rs9322817 0.691 rs2499666 chr6:105318576 A/G cg02098413 chr6:105308735 HACE1 0.43 8.49 0.42 7.27e-16 Thyroid stimulating hormone; CRC trans rs6485978 0.507 rs7128918 chr11:12641625 C/T cg00122406 chr8:26431736 NA -0.4 -6.5 -0.34 2.98e-10 Height; CRC cis rs9443189 0.526 rs10943255 chr6:76225928 T/A cg01950844 chr6:76311363 SENP6 0.72 9.64 0.47 1.6e-19 Prostate cancer; CRC cis rs12983728 0.572 rs59114323 chr19:58649994 C/T cg24884572 chr19:58661833 ZNF329 0.47 5.88 0.31 9.81e-9 Cholesterol, total; CRC cis rs6831352 0.918 rs34876213 chr4:100062216 G/A cg12011299 chr4:100065546 ADH4 -0.51 -9.59 -0.47 2.27e-19 Alcohol dependence; CRC cis rs6912958 0.712 rs6454641 chr6:88371060 T/C cg12350822 chr6:88032061 C6orf162;GJB7 -0.33 -6.22 -0.32 1.55e-9 Monocyte percentage of white cells; CRC cis rs9549328 0.565 rs35371379 chr13:113616715 T/C cg20742385 chr13:113633654 MCF2L 0.55 9.36 0.46 1.31e-18 Systolic blood pressure; CRC cis rs8005677 1.000 rs8016061 chr14:23375809 A/G cg25600027 chr14:23388339 RBM23 -0.53 -8.37 -0.42 1.63e-15 Cognitive ability (multi-trait analysis); CRC cis rs2304069 0.644 rs216131 chr5:149431223 C/T cg22760475 chr5:149380129 HMGXB3;TIGD6 0.6 6.65 0.34 1.23e-10 HIV-1 control; CRC cis rs35306767 0.855 rs12781100 chr10:838636 C/T cg26597838 chr10:835615 NA 1.31 15.37 0.65 1.53e-40 Eosinophil percentage of granulocytes; CRC cis rs853679 0.517 rs34716816 chr6:28046169 C/A cg03623178 chr6:28175578 NA 0.93 12.26 0.56 9.88e-29 Depression; CRC cis rs1670533 1.000 rs1670534 chr4:1087265 T/C cg27284194 chr4:1044797 NA 0.5 6.33 0.33 7.9e-10 Recombination rate (females); CRC cis rs9901225 1 rs9901225 chr17:40755811 C/T cg23622369 chr17:40706682 HSD17B1 -0.46 -8.04 -0.41 1.59e-14 Colorectal or endometrial cancer; CRC cis rs796364 0.951 rs1105964 chr2:201000776 T/A cg25936922 chr2:200820526 C2orf60;C2orf47 -0.68 -7.48 -0.38 6.93e-13 Schizophrenia; CRC trans rs2303319 0.504 rs56026147 chr2:162614089 T/C cg27342122 chr8:133787442 PHF20L1 -0.72 -6.12 -0.32 2.68e-9 Cognitive function; CRC cis rs875971 0.965 rs697968 chr7:65535033 G/A cg18912574 chr7:65842487 NCRNA00174 -0.37 -6.32 -0.33 8.29e-10 Aortic root size; CRC cis rs35306767 0.623 rs72760943 chr10:1143104 G/A cg20503657 chr10:835505 NA 0.69 8.01 0.4 2e-14 Eosinophil percentage of granulocytes; CRC cis rs2243480 1.000 rs316313 chr7:65593548 G/A cg18252515 chr7:66147081 NA -1.24 -14.68 -0.63 7.09e-38 Diabetic kidney disease; CRC cis rs9393692 0.557 rs17608582 chr6:26318799 C/A cg13736514 chr6:26305472 NA -0.45 -7.24 -0.37 3.18e-12 Educational attainment; CRC trans rs7395662 0.963 rs6485865 chr11:48575989 G/T cg21153622 chr11:89784906 NA -0.47 -7.57 -0.39 3.82e-13 HDL cholesterol; CRC cis rs8180040 1.000 rs7613282 chr3:47389409 C/T cg27129171 chr3:47204927 SETD2 -0.68 -10.78 -0.51 2.03e-23 Colorectal cancer; CRC trans rs1814175 0.588 rs1721994 chr11:49914050 G/A cg15704280 chr7:45808275 SEPT13 -0.95 -16.82 -0.68 3.11e-46 Height; CRC cis rs12476592 0.714 rs262492 chr2:63844685 G/A cg10828910 chr2:63850056 LOC388955 0.55 6.7 0.35 8.99e-11 Childhood ear infection; CRC cis rs10504229 0.953 rs57669205 chr8:58172253 T/C cg01721255 chr8:58191610 C8orf71 0.49 6.17 0.32 2.04e-9 Developmental language disorder (linguistic errors); CRC cis rs6582630 0.531 rs3850000 chr12:38483752 T/C cg26384229 chr12:38710491 ALG10B 0.72 10.11 0.49 4.19e-21 Drug-induced liver injury (flucloxacillin); CRC cis rs55794721 0.509 rs2982358 chr1:25745204 G/T cg27572855 chr1:25598939 RHD 0.35 6.28 0.33 1.04e-9 Plateletcrit;Mean corpuscular volume; CRC cis rs2739330 0.796 rs5760106 chr22:24250645 A/C cg24846343 chr22:24311635 DDTL -0.82 -14.05 -0.61 1.82e-35 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs9399135 0.967 rs6902954 chr6:135313994 C/A cg22676075 chr6:135203613 NA 0.44 6.86 0.35 3.38e-11 Red blood cell count; CRC cis rs9303280 0.559 rs4795408 chr17:38107627 G/A cg00129232 chr17:37814104 STARD3 0.38 5.64 0.3 3.76e-8 Self-reported allergy; CRC cis rs853679 0.517 rs9393886 chr6:28050039 T/G cg15845792 chr6:28175446 NA 0.97 13.15 0.59 4.96e-32 Depression; CRC cis rs9309711 0.544 rs9309712 chr2:3491327 G/T cg10845886 chr2:3471009 TTC15 -0.4 -6.29 -0.33 9.84e-10 Neurofibrillary tangles; CRC cis rs763014 0.932 rs35067229 chr16:649638 T/C cg09263875 chr16:632152 PIGQ 0.79 13.0 0.58 1.77e-31 Height; CRC cis rs1008375 1.000 rs1008375 chr4:17682834 T/C cg04450456 chr4:17643702 FAM184B 0.38 5.89 0.31 9.61e-9 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs9682041 1.000 rs9682041 chr3:170091902 C/T cg11886554 chr3:170076028 SKIL 0.74 8.28 0.42 3.17e-15 Glomerular filtration rate in non diabetics (creatinine);Glomerular filtration rate (creatinine); CRC cis rs35264875 0.851 rs72930631 chr11:68867835 T/C cg01993067 chr11:68851601 TPCN2 0.48 6.31 0.33 8.94e-10 Blond vs. brown hair color; CRC cis rs34172651 0.517 rs34172679 chr16:24840381 C/T cg06028605 chr16:24865363 SLC5A11 0.56 8.74 0.43 1.23e-16 Intelligence (multi-trait analysis); CRC cis rs992157 0.767 rs2014615 chr2:219171191 A/G cg04880052 chr2:219191631 PNKD 0.43 6.8 0.35 5.08e-11 Colorectal cancer; CRC cis rs10193935 0.901 rs92303 chr2:42656337 A/G cg27598129 chr2:42591480 NA 0.63 7.45 0.38 8.07e-13 Colonoscopy-negative controls vs population controls; CRC cis rs7626444 0.625 rs1718410 chr3:196477660 A/G cg12930392 chr3:196481615 PAK2 0.4 7.26 0.37 2.73e-12 Monocyte count; CRC trans rs61931739 0.534 rs11052984 chr12:34045904 T/C cg26384229 chr12:38710491 ALG10B 0.51 6.96 0.36 1.82e-11 Morning vs. evening chronotype; CRC cis rs7568498 0.517 rs11678856 chr2:161925443 C/T cg08807892 chr2:162101083 NA -0.44 -6.09 -0.32 3.2e-9 Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 3 peripheral neuropathy); CRC cis rs853679 0.517 rs6922063 chr6:28094366 G/A cg25164649 chr6:28176230 NA 0.75 9.41 0.46 8.75e-19 Depression; CRC cis rs9837602 0.529 rs1688774 chr3:99521108 C/T cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G -0.48 -6.43 -0.33 4.59e-10 Breast cancer; CRC cis rs2032447 0.610 rs189911 chr6:25965942 A/G cg17691542 chr6:26056736 HIST1H1C 0.41 5.66 0.3 3.24e-8 Intelligence (multi-trait analysis); CRC cis rs10924970 0.967 rs10754589 chr1:235439755 T/C cg26050004 chr1:235667680 B3GALNT2 0.4 6.01 0.31 4.84e-9 Asthma; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg20770540 chr3:123304003 PTPLB -0.45 -6.86 -0.35 3.41e-11 Myopia (pathological); CRC cis rs9814567 1.000 rs9864346 chr3:134312352 G/A cg06109529 chr3:134205091 CEP63;ANAPC13 -0.81 -12.14 -0.56 2.75e-28 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs1552244 0.882 rs13066757 chr3:10045030 C/A cg10729496 chr3:10149963 C3orf24 0.51 6.65 0.34 1.23e-10 Alzheimer's disease; CRC cis rs9311474 0.508 rs6786043 chr3:52604861 A/G cg18099408 chr3:52552593 STAB1 -0.46 -7.97 -0.4 2.56e-14 Electroencephalogram traits; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg10143433 chr3:183353451 KLHL24 0.4 6.31 0.33 9.16e-10 Liver disease severity in Alagille syndrome; CRC trans rs877282 0.853 rs7079450 chr10:755932 T/A cg22713356 chr15:30763199 NA 1.19 13.88 0.61 8.17e-35 Uric acid levels; CRC cis rs4555082 0.874 rs2816621 chr14:105732762 A/T cg10792982 chr14:105748885 BRF1 0.38 6.27 0.33 1.15e-9 Mean platelet volume;Platelet distribution width; CRC cis rs853679 0.517 rs4713144 chr6:28106790 C/G cg25164649 chr6:28176230 NA 0.76 9.53 0.46 3.71e-19 Depression; CRC cis rs9322193 0.962 rs2065664 chr6:150083621 A/G cg07701084 chr6:150067640 NUP43 0.4 5.71 0.3 2.48e-8 Lung cancer; CRC cis rs4731207 0.596 rs1006334 chr7:124628307 G/T cg23710748 chr7:124431027 NA -0.4 -6.37 -0.33 6.34e-10 Cutaneous malignant melanoma; CRC cis rs13191362 0.935 rs34934114 chr6:163082480 G/A cg23758597 chr6:163146217 PARK2 -0.65 -6.52 -0.34 2.68e-10 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs10751667 1.000 rs7927156 chr11:970607 A/G cg01483505 chr11:975446 AP2A2 0.4 5.77 0.3 1.84e-8 Alzheimer's disease (late onset); CRC cis rs11148252 0.716 rs3803262 chr13:53036398 A/G cg00495681 chr13:53174319 NA 0.59 8.79 0.44 8.25e-17 Lewy body disease; CRC cis rs1348850 0.958 rs1405713 chr2:178461560 G/C cg02961200 chr2:178257176 LOC100130691;AGPS 0.52 7.53 0.38 4.83e-13 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs370915 0.542 rs1895844 chr4:187833759 C/T cg19519643 chr4:187840862 NA -0.62 -10.51 -0.5 1.81e-22 Gout; CRC cis rs1976403 0.659 rs10799699 chr1:21820961 C/T cg02390115 chr1:21767211 NBPF3 0.55 8.35 0.42 1.92e-15 Liver enzyme levels (alkaline phosphatase); CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg19757154 chr17:74099924 EXOC7 0.45 6.25 0.33 1.28e-9 Anxiety disorder; CRC cis rs1949733 0.523 rs56053534 chr4:8542876 G/A cg11789530 chr4:8429930 ACOX3 -0.58 -7.79 -0.39 8.6e-14 Response to antineoplastic agents; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg05585129 chr12:132413985 PUS1 0.45 6.6 0.34 1.63e-10 Intelligence (multi-trait analysis); CRC cis rs11105298 0.891 rs12228177 chr12:89862030 G/T cg08166232 chr12:89918718 WDR51B;GALNT4 -0.61 -7.77 -0.39 1.01e-13 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; CRC cis rs28386778 0.897 rs2584624 chr17:61904546 A/G cg07362569 chr17:61921086 SMARCD2 0.38 5.95 0.31 6.92e-9 Prudent dietary pattern; CRC trans rs637571 0.522 rs3016868 chr11:65764383 C/T cg17712092 chr4:129076599 LARP1B 0.69 11.54 0.54 4.11e-26 Eosinophil percentage of white cells; CRC cis rs1348850 0.958 rs4528793 chr2:178464271 C/T cg02961200 chr2:178257176 LOC100130691;AGPS 0.52 7.53 0.38 4.83e-13 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs2257205 0.667 rs9912325 chr17:56873934 A/G cg25885038 chr17:56607967 SEPT4 -0.53 -5.75 -0.3 2.07e-8 Pancreatic cancer; CRC cis rs9311474 0.597 rs13303 chr3:52558008 T/C cg15147215 chr3:52552868 STAB1 -0.78 -15.83 -0.66 2.38e-42 Electroencephalogram traits; CRC cis rs7746199 0.668 rs7749305 chr6:27446566 T/C cg12273811 chr6:28175739 NA 0.68 5.73 0.3 2.22e-8 Gait speed in old age;Autism spectrum disorder or schizophrenia; CRC cis rs950169 0.920 rs2135551 chr15:84707851 A/G cg17507749 chr15:85114479 UBE2QP1 0.78 12.03 0.55 6.93e-28 Schizophrenia; CRC cis rs7408868 0.908 rs10416865 chr19:15277601 T/C cg14696996 chr19:15285081 NOTCH3 0.96 9.0 0.44 1.82e-17 Pulse pressure; CRC cis rs3018066 0.831 rs4470632 chr4:106946579 C/T cg01869342 chr4:106983673 TBCK 0.41 6.22 0.32 1.47e-9 Cancer; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg07116851 chr12:58146173 CDK4 0.42 7.01 0.36 1.36e-11 Liver disease severity in Alagille syndrome; CRC cis rs7208859 0.623 rs34756112 chr17:29113016 A/G cg13385521 chr17:29058706 SUZ12P 0.74 8.44 0.42 9.97e-16 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs10461617 0.617 rs1423623 chr5:56065575 A/G cg03609598 chr5:56110824 MAP3K1 0.57 7.5 0.38 5.84e-13 Type 2 diabetes; CRC cis rs9372498 0.572 rs62422190 chr6:118909235 A/G cg18833306 chr6:118973337 C6orf204 0.43 5.63 0.3 3.92e-8 Diastolic blood pressure; CRC cis rs6570726 0.935 rs421268 chr6:145845558 A/T cg05347473 chr6:146136440 FBXO30 0.38 6.09 0.32 3.19e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs977987 0.735 rs11149831 chr16:75451461 G/A cg03315344 chr16:75512273 CHST6 0.58 9.55 0.47 3.07e-19 Dupuytren's disease; CRC cis rs672059 0.806 rs3754524 chr1:183153267 C/T ch.1.3577855R chr1:183094577 LAMC1 0.56 7.96 0.4 2.88e-14 Hypertriglyceridemia; CRC cis rs2011503 1.000 rs4808951 chr19:19550306 C/G cg11584989 chr19:19387371 SF4 0.53 5.96 0.31 6.67e-9 Bipolar disorder; CRC cis rs1451375 0.785 rs10278338 chr7:50630270 C/T cg14593290 chr7:50529359 DDC 0.58 7.92 0.4 3.64e-14 Malaria; CRC cis rs116095464 0.558 rs112343653 chr5:257174 G/A cg22496380 chr5:211416 CCDC127 -0.91 -10.46 -0.5 2.65e-22 Breast cancer; CRC cis rs870825 0.616 rs1401359 chr4:185640216 T/C cg04058563 chr4:185651563 MLF1IP 0.73 9.7 0.47 9.94e-20 Blood protein levels; CRC cis rs1862618 0.641 rs252893 chr5:56224714 T/C cg24531977 chr5:56204891 C5orf35 -0.68 -10.33 -0.49 7.34e-22 Initial pursuit acceleration; CRC cis rs2153535 0.580 rs2327060 chr6:8447111 G/A cg07606381 chr6:8435919 SLC35B3 0.66 10.64 0.51 6.48e-23 Motion sickness; CRC cis rs4481887 0.927 rs4916087 chr1:248493833 T/C cg13385794 chr1:248469461 NA 0.38 6.56 0.34 2.08e-10 Common traits (Other); CRC cis rs4713118 0.662 rs149901 chr6:27965503 C/T cg21251018 chr6:28226885 NKAPL 0.45 6.89 0.36 2.83e-11 Parkinson's disease; CRC cis rs79349575 0.783 rs12602746 chr17:47031741 A/C cg22482690 chr17:47019901 SNF8 0.5 8.26 0.41 3.58e-15 Type 2 diabetes; CRC cis rs800160 0.777 rs2651783 chr11:2345890 C/T cg09785033 chr11:2336066 TSPAN32 -0.47 -5.85 -0.31 1.16e-8 Bacteremia; CRC cis rs7927771 0.839 rs3817334 chr11:47650993 C/T cg18512352 chr11:47633146 NA -0.37 -7.49 -0.38 6.59e-13 Subjective well-being; CRC cis rs9902453 0.619 rs1038088 chr17:28074563 T/G cg26525008 chr17:28256777 EFCAB5;SSH2 -0.72 -12.07 -0.55 5.14e-28 Coffee consumption (cups per day); CRC cis rs2836974 0.899 rs2836938 chr21:40574191 C/T cg17971929 chr21:40555470 PSMG1 0.83 11.94 0.55 1.5e-27 Cognitive function; CRC cis rs758324 0.617 rs9717078 chr5:131170891 G/A cg06307176 chr5:131281290 NA 0.43 6.4 0.33 5.5e-10 Alzheimer's disease in APOE e4- carriers; CRC cis rs614226 1.000 rs1614223 chr12:120964043 T/C cg27489772 chr12:121021490 NA 0.49 6.91 0.36 2.53e-11 Type 1 diabetes nephropathy; CRC cis rs2635047 0.542 rs11082567 chr18:44769820 C/T cg19077165 chr18:44547161 KATNAL2 -0.39 -5.76 -0.3 1.97e-8 Educational attainment; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg24932816 chr1:87794052 LMO4 0.39 6.37 0.33 6.28e-10 Liver disease severity in Alagille syndrome; CRC cis rs2204008 0.782 rs117824012 chr12:38215517 T/C cg26384229 chr12:38710491 ALG10B 0.69 9.26 0.45 2.81e-18 Bladder cancer; CRC cis rs9915657 0.773 rs9896360 chr17:70099469 C/G cg09344028 chr17:70110421 NA 0.53 8.73 0.43 1.3e-16 Thyroid hormone levels; CRC cis rs6502050 0.835 rs9646397 chr17:80083534 G/A cg11859384 chr17:80120422 CCDC57 0.37 5.82 0.31 1.36e-8 Life satisfaction; CRC cis rs7829975 0.514 rs2976929 chr8:8258712 T/C cg08975724 chr8:8085496 FLJ10661 0.48 7.31 0.37 2e-12 Mood instability; CRC cis rs7591163 1.000 rs6738964 chr2:228739135 G/T cg08034379 chr2:228736324 WDR69 -0.54 -7.38 -0.38 1.28e-12 Blood pressure; CRC cis rs2297440 0.530 rs34533955 chr20:62233020 A/C cg09650180 chr20:62225654 GMEB2 -0.5 -6.46 -0.34 3.84e-10 Glioma;Non-glioblastoma glioma;Glioblastoma; CRC cis rs1218582 0.741 rs11264291 chr1:154914797 C/T cg03351412 chr1:154909251 PMVK 0.51 8.01 0.4 2.03e-14 Prostate cancer; CRC cis rs17376456 1.000 rs35184505 chr5:93561535 A/G cg25358565 chr5:93447407 FAM172A 1.09 9.7 0.47 9.72e-20 Diabetic retinopathy; CRC cis rs6502050 0.764 rs35416122 chr17:80119006 A/G cg09264619 chr17:80180166 NA -0.35 -5.93 -0.31 7.47e-9 Life satisfaction; CRC cis rs1105228 0.715 rs547269 chr6:165714538 A/T cg20535254 chr6:165714960 C6orf118 -0.29 -6.03 -0.32 4.33e-9 Number of pregnancies;Number of children; CRC cis rs1465370 0.682 rs62471720 chr7:130016359 C/G cg03229158 chr7:130009420 NA 0.47 6.65 0.34 1.19e-10 Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction);Waist circumference adjusted for BMI in active individuals;Waist circumference adjusted for body mass index; CRC cis rs2842992 0.715 rs2277073 chr6:160182749 G/A cg19482086 chr6:160211437 TCP1;MRPL18 0.73 9.59 0.47 2.32e-19 Age-related macular degeneration (geographic atrophy); CRC cis rs9649213 0.593 rs10808107 chr7:97951671 T/C cg24562669 chr7:97807699 LMTK2 0.42 7.02 0.36 1.24e-11 Prostate cancer (SNP x SNP interaction); CRC trans rs615632 0.570 rs17734541 chr8:9708433 A/G cg16141378 chr3:129829833 LOC729375 -0.45 -7.0 -0.36 1.45e-11 Neuroticism; CRC cis rs2415984 0.562 rs1389605 chr14:46964784 T/C cg14871534 chr14:47121158 RPL10L 0.4 5.61 0.3 4.37e-8 Number of children ever born; CRC cis rs67478160 0.619 rs12886363 chr14:104273786 T/C cg01849466 chr14:104193079 ZFYVE21 -0.43 -7.28 -0.37 2.44e-12 Schizophrenia; CRC cis rs9768139 0.708 rs896781 chr7:158114114 T/C cg25566285 chr7:158114605 PTPRN2 0.52 8.47 0.42 8.52e-16 Calcium levels; CRC cis rs2712184 1.000 rs2712184 chr2:217682779 G/T cg05032264 chr2:217675019 NA -0.32 -5.61 -0.3 4.34e-8 Glomerular filtration rate;Glomerular filtration rate in non diabetics (creatinine); CRC cis rs2836950 0.545 rs11701805 chr21:40618683 T/C cg06238570 chr21:40685208 BRWD1 -0.62 -8.95 -0.44 2.72e-17 Menarche (age at onset); CRC cis rs6500395 0.962 rs11648101 chr16:48714178 C/T cg04672837 chr16:48644449 N4BP1 0.42 5.97 0.31 6.27e-9 Response to tocilizumab in rheumatoid arthritis; CRC cis rs7617773 0.817 rs745116 chr3:48272536 T/G cg11946769 chr3:48343235 NME6 0.63 8.68 0.43 1.88e-16 Coronary artery disease; CRC cis rs12541635 0.833 rs4734130 chr8:107096458 A/G cg10147462 chr8:107024639 NA -0.41 -6.37 -0.33 6.34e-10 Age of smoking initiation; CRC cis rs10256972 0.552 rs6978842 chr7:1204599 A/C cg07092213 chr7:1199455 ZFAND2A -0.46 -6.74 -0.35 7.19e-11 Longevity;Endometriosis; CRC trans rs208520 0.690 rs207118 chr6:66788948 T/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.08 -15.36 -0.65 1.56e-40 Exhaled nitric oxide output; CRC cis rs2976388 1.000 rs2572910 chr8:143770135 C/G cg12516270 chr8:143859308 LYNX1 -0.34 -5.87 -0.31 1.07e-8 Urinary tract infection frequency; CRC cis rs1046896 0.561 rs8076476 chr17:80861017 A/C cg08200770 chr17:80723486 TBCD -0.49 -7.45 -0.38 8.31e-13 Glycated hemoglobin levels; CRC trans rs4332037 0.615 rs62435134 chr7:1895463 T/G cg11693508 chr17:37793320 STARD3 0.7 8.7 0.43 1.62e-16 Bipolar disorder; CRC cis rs2274273 0.638 rs58269011 chr14:55684388 A/G cg10130446 chr14:55658398 DLGAP5 -0.43 -5.83 -0.31 1.33e-8 Protein biomarker; CRC cis rs9399135 0.660 rs9389248 chr6:135282656 T/C cg22676075 chr6:135203613 NA 0.54 8.16 0.41 7.01e-15 Red blood cell count; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg00613399 chr15:89010912 MRPL46;MRPS11 0.43 5.98 0.31 5.76e-9 Response to antipsychotic treatment; CRC cis rs6964587 0.626 rs6972945 chr7:91549576 C/G cg17063962 chr7:91808500 NA -0.59 -9.53 -0.47 3.6e-19 Breast cancer; CRC cis rs7259376 0.875 rs1991830 chr19:22514730 G/A cg02657401 chr19:22469223 NA -0.37 -8.15 -0.41 7.51e-15 Menopause (age at onset); CRC cis rs2836974 0.897 rs6517513 chr21:40526878 A/G cg06238570 chr21:40685208 BRWD1 0.71 10.1 0.49 4.5e-21 Cognitive function; CRC cis rs929354 0.772 rs10230895 chr7:157007038 T/C cg16102536 chr7:156981717 UBE3C 0.4 6.77 0.35 5.75e-11 Body mass index; CRC cis rs4481887 0.830 rs10888341 chr1:248441995 T/C cg00666640 chr1:248458726 OR2T12 0.53 9.57 0.47 2.59e-19 Common traits (Other); CRC cis rs12893668 0.572 rs35011804 chr14:104151400 C/T cg08213375 chr14:104286397 PPP1R13B 0.44 6.89 0.36 2.77e-11 Reticulocyte count; CRC cis rs4808199 0.895 rs2163805 chr19:19575945 G/A cg03709012 chr19:19516395 GATAD2A 1.0 11.99 0.55 1.01e-27 Nonalcoholic fatty liver disease; CRC cis rs17666538 0.792 rs7820788 chr8:601846 C/T cg00450029 chr8:599525 NA 0.63 5.65 0.3 3.52e-8 IgG glycosylation; CRC cis rs1519814 1.000 rs6983133 chr8:121166682 T/G cg22335954 chr8:121166405 COL14A1 -0.59 -6.84 -0.35 3.81e-11 Breast cancer; CRC cis rs34779708 0.931 rs11010132 chr10:35517265 C/G cg03585969 chr10:35415529 CREM 0.53 7.05 0.36 1.04e-11 Inflammatory bowel disease;Crohn's disease; CRC cis rs908922 0.676 rs10888492 chr1:152499908 G/C cg23254163 chr1:152506842 NA 0.49 9.72 0.47 8.37e-20 Hair morphology; CRC cis rs11098499 1.000 rs11726229 chr4:120211580 C/T cg24375607 chr4:120327624 NA 0.46 7.16 0.37 5.18e-12 Corneal astigmatism; CRC cis rs7212590 0.655 rs34687426 chr17:57997857 A/G cg10252138 chr17:58120427 NA -0.55 -5.93 -0.31 7.76e-9 Granulocyte percentage of myeloid white cells;Monocyte count;Monocyte percentage of white cells; CRC cis rs853679 0.517 rs4711164 chr6:28115156 C/T cg12172441 chr6:28176163 NA 0.64 7.53 0.38 5.03e-13 Depression; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg01776903 chr15:38543564 SPRED1 0.43 6.17 0.32 2.06e-9 Response to antipsychotic treatment; CRC cis rs72781680 0.611 rs72797824 chr2:24356456 T/G cg20701182 chr2:24300061 SF3B14 0.58 7.06 0.36 9.73e-12 Lymphocyte counts; CRC cis rs67478160 0.634 rs941475 chr14:104240618 A/C cg08213375 chr14:104286397 PPP1R13B 0.58 11.71 0.54 1.04e-26 Schizophrenia; CRC cis rs2228479 0.850 rs17227057 chr16:89816333 C/T cg19635926 chr16:89946313 TCF25 0.66 5.97 0.31 6.1e-9 Skin colour saturation; CRC cis rs1113500 0.897 rs2336127 chr1:108640870 G/A cg06207961 chr1:108661230 NA 0.39 5.7 0.3 2.6e-8 Growth-regulated protein alpha levels; CRC cis rs7113874 0.569 rs10160805 chr11:8600393 C/T cg17679104 chr11:8615758 STK33 0.36 6.02 0.32 4.6e-9 Body mass index in physically active individuals;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs1448094 0.512 rs57278040 chr12:86237886 A/G cg00310523 chr12:86230176 RASSF9 0.34 5.63 0.3 3.78e-8 Major depressive disorder; CRC cis rs9457247 0.602 rs12209395 chr6:167463914 C/T cg07741184 chr6:167504864 NA 0.44 7.51 0.38 5.68e-13 Crohn's disease; CRC cis rs5769765 0.955 rs9616368 chr22:50303533 C/G cg22709217 chr22:50311962 ALG12;CRELD2 -1.01 -16.54 -0.67 3.83e-45 Schizophrenia; CRC cis rs3126085 0.935 rs4361987 chr1:152229701 A/G cg09127314 chr1:152161683 NA 0.49 6.33 0.33 7.87e-10 Atopic dermatitis; CRC cis rs6547741 1.000 rs1080060 chr2:27768808 T/A cg27432699 chr2:27873401 GPN1 0.76 13.55 0.6 1.51e-33 Oral cavity cancer; CRC cis rs2952156 0.920 rs2517953 chr17:37841211 G/C cg20243544 chr17:37824526 PNMT 0.57 9.07 0.45 1.12e-17 Asthma; CRC cis rs6460942 0.908 rs6979124 chr7:12232551 G/T cg06484146 chr7:12443880 VWDE -0.59 -6.19 -0.32 1.77e-9 Coronary artery disease; CRC cis rs79387448 0.701 rs76943877 chr2:102970677 T/C cg09003973 chr2:102972529 NA 0.94 9.9 0.48 2.13e-20 Gut microbiota (bacterial taxa); CRC cis rs853679 0.517 rs9368552 chr6:28068426 A/G cg02631126 chr6:28058918 ZSCAN12L1 0.3 6.11 0.32 2.83e-9 Depression; CRC cis rs3741404 0.620 rs11231722 chr11:63967770 C/G cg06243084 chr11:63990629 FERMT3 -0.4 -6.24 -0.33 1.31e-9 Platelet count; CRC cis rs11249608 0.548 rs13161528 chr5:178452958 C/G cg01312482 chr5:178451176 ZNF879 -0.36 -6.11 -0.32 2.75e-9 Pubertal anthropometrics; CRC cis rs4927850 0.709 rs6765762 chr3:195652851 G/A cg12923728 chr3:195709715 SDHAP1 -0.69 -9.1 -0.45 8.57e-18 Pancreatic cancer; CRC cis rs4631830 0.720 rs898343 chr10:51505403 A/G cg20129853 chr10:51489980 NA 0.34 5.7 0.3 2.61e-8 Prostate-specific antigen levels; CRC cis rs9837602 1.000 rs2291494 chr3:99781805 G/A cg07805332 chr3:99536008 MIR548G;C3orf26 -0.47 -6.19 -0.32 1.75e-9 Breast cancer; CRC cis rs644799 0.687 rs11021318 chr11:95522996 T/C cg25622487 chr11:95524042 FAM76B;CEP57 0.8 13.51 0.6 2.08e-33 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs7726839 0.526 rs11960159 chr5:568685 C/T cg14541582 chr5:601475 NA -0.27 -5.64 -0.3 3.72e-8 Obesity-related traits; CRC cis rs17443541 0.507 rs6755597 chr2:200451440 A/G cg03741458 chr2:200468445 NA -0.38 -5.95 -0.31 6.72e-9 Intelligence (multi-trait analysis); CRC cis rs11690935 0.788 rs10201053 chr2:172889558 A/G cg13550731 chr2:172543902 DYNC1I2 -0.92 -13.85 -0.61 1.11e-34 Schizophrenia; CRC cis rs6951245 0.638 rs4720486 chr7:1146764 G/A cg18402987 chr7:1209562 NA 0.55 6.65 0.34 1.19e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs7613875 0.537 rs6446195 chr3:50070853 A/G cg24308560 chr3:49941425 MST1R 0.42 6.52 0.34 2.65e-10 Body mass index; CRC cis rs1865760 0.566 rs9295688 chr6:26084217 G/A cg18357526 chr6:26021779 HIST1H4A 0.41 5.83 0.31 1.32e-8 Height; CRC cis rs9649213 0.593 rs1468341 chr7:97987696 G/A cg21770322 chr7:97807741 LMTK2 0.52 8.47 0.42 8.07e-16 Prostate cancer (SNP x SNP interaction); CRC cis rs13191362 0.507 rs13197051 chr6:163201728 A/T cg06582575 chr6:163149167 PACRG;PARK2 0.53 8.07 0.41 1.37e-14 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs1552244 0.882 rs3732967 chr3:10015437 T/C cg13047869 chr3:10149882 C3orf24 0.51 6.91 0.36 2.54e-11 Alzheimer's disease; CRC cis rs9322193 0.923 rs9479494 chr6:150060244 A/G cg05861140 chr6:150128134 PCMT1 -0.37 -5.89 -0.31 9.29e-9 Lung cancer; CRC cis rs7954584 0.531 rs1154514 chr12:122374888 C/T cg21171335 chr12:122356390 WDR66 0.39 6.02 0.32 4.54e-9 Mean corpuscular volume; CRC cis rs11971779 0.680 rs11764236 chr7:139118514 C/T cg07862535 chr7:139043722 LUC7L2 0.73 8.98 0.44 2.2e-17 Diisocyanate-induced asthma; CRC cis rs9902453 0.904 rs4375718 chr17:28363642 C/T cg26525008 chr17:28256777 EFCAB5;SSH2 -0.75 -12.68 -0.57 2.94e-30 Coffee consumption (cups per day); CRC cis rs990171 1.000 rs6713618 chr2:103048437 A/T cg03938978 chr2:103052716 IL18RAP 0.46 5.9 0.31 9.09e-9 Lymphocyte counts; CRC trans rs9929218 0.581 rs12185157 chr16:68784587 G/A cg04657470 chr2:198365150 HSPE1;HSPD1 0.99 19.25 0.73 7.84e-56 Colorectal cancer; CRC cis rs4594175 0.926 rs9323207 chr14:51621908 A/G cg23942311 chr14:51606299 NA -0.65 -10.84 -0.51 1.26e-23 Cancer; CRC cis rs2832191 1.000 rs6516891 chr21:30483070 C/T cg24692254 chr21:30365293 RNF160 -0.64 -11.05 -0.52 2.43e-24 Dental caries; CRC cis rs11112613 0.775 rs10507194 chr12:105959488 G/A cg03607813 chr12:105948248 NA 0.8 10.45 0.5 2.88e-22 Corrected insulin response;Corrected insulin response adjusted for insulin sensitivity index; CRC cis rs4713118 0.739 rs2893931 chr6:27748010 G/A cg15786705 chr6:28176104 NA 0.54 7.06 0.36 1.01e-11 Parkinson's disease; CRC cis rs9814567 0.929 rs1534027 chr3:134284662 T/A cg06109529 chr3:134205091 CEP63;ANAPC13 -0.81 -12.21 -0.56 1.57e-28 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs6582630 0.502 rs1915395 chr12:38420726 A/G cg13010199 chr12:38710504 ALG10B 0.45 5.72 0.3 2.37e-8 Drug-induced liver injury (flucloxacillin); CRC cis rs2228479 0.702 rs62053702 chr16:89860688 G/T cg19635926 chr16:89946313 TCF25 0.67 6.25 0.33 1.25e-9 Skin colour saturation; CRC cis rs60843830 1.000 rs56167434 chr2:282137 G/C cg00108164 chr2:264199 ACP1;SH3YL1 0.61 9.56 0.47 2.79e-19 Spherical equivalent (joint analysis main effects and education interaction); CRC cis rs853679 0.824 rs34712084 chr6:28043828 A/G cg03623178 chr6:28175578 NA 0.84 6.98 0.36 1.68e-11 Depression; CRC cis rs10788264 0.544 rs911786 chr10:124017583 C/G cg05683857 chr10:124030795 BTBD16 0.33 5.92 0.31 7.98e-9 Total body bone mineral density; CRC cis rs644799 0.526 rs534973 chr11:95633624 A/T cg25622487 chr11:95524042 FAM76B;CEP57 0.55 8.19 0.41 5.71e-15 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs12594515 1.000 rs8031128 chr15:45988528 C/G cg22117107 chr15:45993392 NA -0.44 -9.09 -0.45 9.56e-18 Waist circumference;Weight; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg19215386 chr18:72921446 TSHZ1;ZADH2 0.4 6.45 0.34 4e-10 Liver disease severity in Alagille syndrome; CRC cis rs1375194 0.606 rs10188817 chr2:33815471 A/G cg04131969 chr2:33951647 MYADML -0.52 -7.55 -0.38 4.27e-13 Response to antidepressants in depression; CRC trans rs6550704 0.687 rs9865314 chr3:22634337 A/G cg14543941 chr10:71079214 HK1 -0.41 -6.15 -0.32 2.25e-9 Daytime sleep phenotypes; CRC cis rs59574136 1 rs59574136 chr7:2036460 T/C cg00106254 chr7:1943704 MAD1L1 -0.54 -7.98 -0.4 2.41e-14 Autism spectrum disorder or schizophrenia; CRC cis rs6500395 0.926 rs11645193 chr16:48594229 C/T cg04672837 chr16:48644449 N4BP1 0.42 5.99 0.31 5.43e-9 Response to tocilizumab in rheumatoid arthritis; CRC cis rs2227564 0.729 rs2675675 chr10:75649048 G/A cg00564723 chr10:75632066 CAMK2G -0.33 -7.63 -0.39 2.58e-13 Crohn's disease;Inflammatory bowel disease; CRC cis rs6998277 0.830 rs7017839 chr8:103610769 G/C cg10187029 chr8:103597600 NA 0.93 15.22 0.64 5.87e-40 Migraine; CRC cis rs12541335 0.590 rs11136002 chr8:22217082 C/T cg02463440 chr8:22132932 PIWIL2 0.51 8.83 0.44 6.25e-17 Hypertriglyceridemia; CRC trans rs10506458 0.915 rs2013042 chr12:63394211 A/G cg03429785 chr15:59498649 MYO1E;LDHAL6B -1.39 -20.05 -0.74 5.45e-59 Hemostatic factors and hematological phenotypes; CRC cis rs977987 0.806 rs12924920 chr16:75440133 G/A cg03315344 chr16:75512273 CHST6 0.54 9.08 0.45 1.01e-17 Dupuytren's disease; CRC cis rs7666738 0.830 rs6811940 chr4:98777898 G/A cg17366294 chr4:99064904 C4orf37 0.42 6.87 0.35 3.3e-11 Colonoscopy-negative controls vs population controls; CRC cis rs28386778 0.591 rs2584619 chr17:61913215 T/A cg23090583 chr17:61904693 PSMC5;FTSJ3 1.05 20.7 0.75 1.5e-61 Prudent dietary pattern; CRC cis rs875971 0.545 rs316306 chr7:65618674 G/A cg03233332 chr7:66118400 NA 0.45 6.22 0.32 1.49e-9 Aortic root size; CRC cis rs9487051 0.676 rs6925716 chr6:109597641 T/C cg21918786 chr6:109611834 NA -0.41 -7.23 -0.37 3.51e-12 Reticulocyte fraction of red cells; CRC cis rs4665809 1.000 rs4665811 chr2:26260017 A/G cg27170947 chr2:26402098 FAM59B -0.44 -5.81 -0.3 1.51e-8 Gut microbiome composition (summer); CRC trans rs1997103 1.000 rs10263552 chr7:55404747 C/T cg20935933 chr6:143382018 AIG1 0.51 6.68 0.35 1.03e-10 QRS interval (sulfonylurea treatment interaction); CRC cis rs10504073 0.584 rs17642664 chr8:49942945 A/G cg00325661 chr8:49890786 NA 0.58 10.58 0.5 1.07e-22 Blood metabolite ratios; CRC cis rs1451375 0.698 rs12669770 chr7:50656334 G/A cg14593290 chr7:50529359 DDC 0.52 7.11 0.36 7.42e-12 Malaria; CRC cis rs2032447 0.831 rs9467664 chr6:26021813 A/T cg12588279 chr6:26043732 HIST1H2BB 0.48 6.84 0.35 3.97e-11 Intelligence (multi-trait analysis); CRC cis rs1757171 0.542 rs1757186 chr6:37484111 A/G cg25019722 chr6:37503610 NA -0.47 -8.63 -0.43 2.66e-16 Cognitive performance; CRC cis rs6502050 0.871 rs62079994 chr17:80076516 T/C cg13198984 chr17:80129470 CCDC57 -0.48 -8.57 -0.43 3.99e-16 Life satisfaction; CRC cis rs8032158 1.000 rs8024944 chr15:56125135 C/A cg02198044 chr15:56286336 NEDD4 -0.38 -5.97 -0.31 6.31e-9 Keloid; CRC cis rs2688482 0.512 rs3103953 chr3:195520597 G/A cg18713687 chr3:195489789 MUC4 -0.66 -7.32 -0.37 1.88e-12 Lung disease severity in cystic fibrosis; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg23139801 chr20:10414776 C20orf94;MKKS 0.47 6.61 0.34 1.57e-10 Response to antipsychotic treatment; CRC cis rs8031584 1.000 rs1474380 chr15:31269235 T/C cg08109568 chr15:31115862 NA -0.52 -8.8 -0.44 7.82e-17 Huntington's disease progression; CRC cis rs57221529 0.766 rs56350081 chr5:583198 G/A cg14541582 chr5:601475 NA -0.37 -7.19 -0.37 4.49e-12 Lung disease severity in cystic fibrosis; CRC cis rs9660992 0.573 rs12125276 chr1:205199440 C/T cg21643547 chr1:205240462 TMCC2 -0.38 -6.08 -0.32 3.27e-9 Mean corpuscular volume;Mean platelet volume; CRC cis rs1712517 0.873 rs1891292 chr10:105001510 A/G cg05636881 chr10:105038444 INA -0.47 -8.38 -0.42 1.56e-15 Migraine; CRC cis rs992157 0.560 rs4674275 chr2:219097738 G/A cg04731861 chr2:219085781 ARPC2 0.37 7.99 0.4 2.37e-14 Colorectal cancer; CRC cis rs7552404 0.883 rs11161493 chr1:76206254 T/A cg22875332 chr1:76189707 ACADM 0.8 11.88 0.55 2.44e-27 Blood metabolite levels;Acylcarnitine levels; CRC cis rs877426 0.515 rs57506460 chr13:114767789 G/A cg03423767 chr13:114876390 RASA3 0.37 6.32 0.33 8.4e-10 Facial morphology (factor 14, intercanthal width); CRC cis rs798554 0.679 rs798499 chr7:2792013 G/A cg19717773 chr7:2847554 GNA12 -0.43 -7.14 -0.37 5.85e-12 Height; CRC cis rs9487051 0.768 rs351752 chr6:109536034 C/A cg01475377 chr6:109611718 NA -0.34 -5.9 -0.31 9.23e-9 Reticulocyte fraction of red cells; CRC cis rs1862618 0.853 rs43184 chr5:56141777 G/C cg24531977 chr5:56204891 C5orf35 -0.82 -10.94 -0.52 5.83e-24 Initial pursuit acceleration; CRC cis rs9322193 0.962 rs4869731 chr6:150131208 T/C cg13206674 chr6:150067644 NUP43 0.57 8.16 0.41 6.99e-15 Lung cancer; CRC cis rs6459788 0.693 rs11981578 chr7:157250133 C/T cg06271696 chr7:157225062 NA -0.57 -9.65 -0.47 1.5e-19 Epstein-Barr virus copy number in lymphoblastoid cell lines; CRC cis rs3789045 0.774 rs12028476 chr1:204476361 G/A cg17419461 chr1:204415978 PIK3C2B -0.57 -7.89 -0.4 4.47e-14 Educational attainment (college completion); CRC cis rs7849270 0.959 rs3124509 chr9:131896999 C/T cg13538475 chr9:131942899 NA 0.34 6.51 0.34 2.85e-10 Blood metabolite ratios; CRC cis rs6456156 0.774 rs6908364 chr6:167527296 C/T cg07513332 chr6:167530253 CCR6 -0.43 -7.95 -0.4 2.96e-14 Primary biliary cholangitis; CRC cis rs17209837 0.607 rs45496691 chr7:87110795 C/A cg00919237 chr7:87102261 ABCB4 -0.51 -6.7 -0.35 9.12e-11 Gallbladder cancer; CRC cis rs2836974 0.966 rs7283420 chr21:40666865 T/C cg17971929 chr21:40555470 PSMG1 0.71 9.71 0.47 8.9e-20 Cognitive function; CRC cis rs929596 0.606 rs7604115 chr2:234658116 C/T cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.62 -9.25 -0.45 2.92e-18 Total bilirubin levels in HIV-1 infection; CRC cis rs765787 0.530 rs12905246 chr15:45500841 C/T cg24006582 chr15:45444508 DUOX1 0.54 7.8 0.39 8.51e-14 Uric acid levels; CRC cis rs1881797 0.527 rs74227706 chr1:247638315 A/C cg18198730 chr1:247681584 NA 0.63 6.91 0.36 2.52e-11 Acute lymphoblastic leukemia (childhood); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg14431619 chr19:11266544 SPC24 0.49 6.94 0.36 2.08e-11 Response to antipsychotic treatment; CRC trans rs7615952 0.546 rs2979338 chr3:125343126 G/T cg02007433 chr3:129722099 NA -0.51 -6.26 -0.33 1.19e-9 Blood pressure (smoking interaction); CRC cis rs2204008 0.654 rs1733410 chr12:38132172 G/A cg26384229 chr12:38710491 ALG10B -0.55 -8.2 -0.41 5.3e-15 Bladder cancer; CRC cis rs599083 0.530 rs576118 chr11:68177708 C/T cg16797656 chr11:68205561 LRP5 -0.39 -6.26 -0.33 1.19e-9 Bone mineral density (spine); CRC trans rs6833159 0.527 rs10939231 chr4:28829372 A/T cg12492157 chr7:27498310 NA 0.42 6.16 0.32 2.15e-9 Underweight status; CRC cis rs9896052 0.572 rs4078474 chr17:73489567 C/G cg25649188 chr17:73499917 CASKIN2 0.44 6.35 0.33 7.2e-10 Sight-threatening diabetic retinopathy in type 2 diabetes; CRC cis rs919433 0.679 rs9967823 chr2:198531529 A/G cg10820045 chr2:198174542 NA 0.33 5.66 0.3 3.3e-8 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC cis rs7680126 0.595 rs17251963 chr4:10142561 A/G cg00071950 chr4:10020882 SLC2A9 -0.49 -6.0 -0.31 5.18e-9 Urate levels in lean individuals;Urate levels in overweight individuals;Urate levels in obese individuals; CRC cis rs10927875 0.541 rs1763599 chr1:16342602 C/T cg24140574 chr1:16342155 HSPB7 0.47 6.74 0.35 7.16e-11 Dilated cardiomyopathy; CRC cis rs7666738 0.830 rs4334758 chr4:98971875 A/G cg17366294 chr4:99064904 C4orf37 0.44 7.44 0.38 8.98e-13 Colonoscopy-negative controls vs population controls; CRC cis rs2180341 0.782 rs6912006 chr6:127722631 C/T cg27446573 chr6:127587934 RNF146 0.61 8.11 0.41 9.84e-15 Breast cancer; CRC cis rs2243480 0.803 rs160649 chr7:65543199 C/T cg25985355 chr7:65971099 NA -0.5 -6.01 -0.31 4.91e-9 Diabetic kidney disease; CRC cis rs6952808 0.929 rs12532128 chr7:1925454 T/C cg22963979 chr7:1858916 MAD1L1 -0.51 -7.57 -0.39 3.83e-13 Bipolar disorder and schizophrenia; CRC cis rs7221595 0.877 rs7219437 chr17:4050138 A/G cg09695851 chr17:3907499 NA 0.46 6.29 0.33 1.02e-9 Functional impairment in major depressive disorder, bipolar disorder and schizophrenia; CRC trans rs116095464 0.614 rs62344292 chr5:244630 G/A cg00938859 chr5:1591904 SDHAP3 0.74 7.88 0.4 5e-14 Breast cancer; CRC cis rs853679 0.567 rs7774981 chr6:28346910 T/C cg21251018 chr6:28226885 NKAPL 0.42 6.05 0.32 3.95e-9 Depression; CRC cis rs4927850 0.881 rs7624638 chr3:195748729 C/T cg12923728 chr3:195709715 SDHAP1 -0.71 -11.0 -0.52 3.56e-24 Pancreatic cancer; CRC cis rs4819052 0.807 rs4819047 chr21:46665139 C/T cg11663144 chr21:46675770 NA -0.81 -13.63 -0.6 7.45e-34 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs9549260 0.755 rs7328677 chr13:41229905 A/G cg21288729 chr13:41239152 FOXO1 0.49 7.7 0.39 1.6e-13 Red blood cell count; CRC cis rs6540559 1.000 rs742215 chr1:209961023 A/T cg22029157 chr1:209979665 IRF6 0.68 9.87 0.48 2.66e-20 Cleft lip with or without cleft palate; CRC cis rs10751667 0.621 rs10794351 chr11:946228 C/T ch.11.42038R chr11:967971 AP2A2 0.58 9.99 0.48 1.08e-20 Alzheimer's disease (late onset); CRC cis rs62064224 0.614 rs8065246 chr17:30682274 T/C cg18200150 chr17:30822561 MYO1D 0.44 8.56 0.43 4.28e-16 Schizophrenia; CRC cis rs35110281 0.667 rs2155722 chr21:45096206 A/G cg01579765 chr21:45077557 HSF2BP 0.36 6.95 0.36 1.95e-11 Mean corpuscular volume; CRC cis rs1707322 0.721 rs10789470 chr1:46158331 T/G cg03146154 chr1:46216737 IPP 0.67 9.82 0.48 3.95e-20 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC trans rs1005277 0.563 rs2505215 chr10:38481273 A/G cg23533926 chr12:111358616 MYL2 -0.54 -8.21 -0.41 5e-15 Extrinsic epigenetic age acceleration; CRC cis rs7618915 0.570 rs13068293 chr3:52672167 C/A cg18404041 chr3:52824283 ITIH1 -0.43 -8.82 -0.44 7.03e-17 Bipolar disorder; CRC cis rs2046867 0.774 rs9820293 chr3:72876237 T/A cg25664220 chr3:72788482 NA -0.41 -6.34 -0.33 7.67e-10 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; CRC cis rs73206853 0.841 rs57726737 chr12:110843701 A/G cg12870014 chr12:110450643 ANKRD13A 0.77 8.17 0.41 6.89e-15 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC trans rs877282 0.947 rs12358875 chr10:757531 T/C cg22713356 chr15:30763199 NA 1.24 14.62 0.63 1.19e-37 Uric acid levels; CRC cis rs2077654 0.822 rs7932122 chr11:17431361 A/G cg25308976 chr11:17434268 ABCC8 -0.79 -8.3 -0.42 2.7e-15 Gout; CRC cis rs68170813 0.559 rs2189501 chr7:106942766 A/T cg02696742 chr7:106810147 HBP1 -0.57 -6.26 -0.33 1.18e-9 Coronary artery disease; CRC cis rs7429990 0.965 rs4858880 chr3:48104449 C/A cg11946769 chr3:48343235 NME6 -0.44 -5.8 -0.3 1.58e-8 Educational attainment (years of education); CRC cis rs897984 0.770 rs12930657 chr16:30931968 C/T cg02466173 chr16:30829666 NA 0.66 9.98 0.48 1.15e-20 Dementia with Lewy bodies; CRC cis rs929354 0.772 rs2301914 chr7:157000176 T/C cg16102536 chr7:156981717 UBE3C 0.4 6.78 0.35 5.69e-11 Body mass index; CRC cis rs1784581 0.588 rs9355971 chr6:162421242 A/G cg17173639 chr6:162384350 PARK2 0.61 9.88 0.48 2.43e-20 Itch intensity from mosquito bite; CRC cis rs950776 0.745 rs36045869 chr15:78929498 C/T cg06917634 chr15:78832804 PSMA4 0.55 8.05 0.41 1.54e-14 Sudden cardiac arrest; CRC cis rs67311347 1.000 rs9822644 chr3:40426609 G/A cg09455208 chr3:40491958 NA 0.48 9.13 0.45 7.17e-18 Renal cell carcinoma; CRC cis rs9910055 0.960 rs9911991 chr17:42278916 G/C cg19774624 chr17:42201019 HDAC5 -0.66 -9.54 -0.47 3.41e-19 Total body bone mineral density; CRC cis rs4665809 0.838 rs7565843 chr2:26292912 G/C cg27170947 chr2:26402098 FAM59B -0.45 -5.96 -0.31 6.38e-9 Gut microbiome composition (summer); CRC cis rs1552244 0.882 rs66559400 chr3:10012551 G/A cg18598329 chr3:10140678 FANCD2;C3orf24 -0.82 -10.77 -0.51 2.31e-23 Alzheimer's disease; CRC cis rs72945132 0.769 rs680571 chr11:70187441 G/A cg00319359 chr11:70116639 PPFIA1 0.65 7.24 0.37 3.14e-12 Coronary artery disease; CRC cis rs4481887 0.604 rs4642918 chr1:248411057 A/C cg00666640 chr1:248458726 OR2T12 -0.39 -6.58 -0.34 1.82e-10 Common traits (Other); CRC cis rs4819052 0.851 rs2838840 chr21:46668494 A/G cg11663144 chr21:46675770 NA -0.83 -14.34 -0.62 1.52e-36 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs4964805 0.505 rs4981032 chr12:104165864 C/T cg02344784 chr12:104178138 NT5DC3 0.47 7.23 0.37 3.35e-12 Attention deficit hyperactivity disorder; CRC cis rs6988985 0.818 rs3802230 chr8:143992864 C/A cg10324643 chr8:143916377 GML 0.4 6.7 0.35 9.3e-11 Plasma androstenedione levels in resected early stage-receptor positive breast cancer; CRC cis rs9814567 1.000 rs9990351 chr3:134239191 A/T cg06109529 chr3:134205091 CEP63;ANAPC13 0.79 11.62 0.54 2.18e-26 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs6456156 0.819 rs9457273 chr6:167520749 A/T cg07513332 chr6:167530253 CCR6 -0.36 -5.99 -0.31 5.55e-9 Primary biliary cholangitis; CRC cis rs9549367 0.789 rs9549715 chr13:113908240 G/C cg18105134 chr13:113819100 PROZ -0.74 -10.5 -0.5 1.94e-22 Platelet distribution width; CRC cis rs1865760 0.713 rs7766342 chr6:25990674 C/A cg16482183 chr6:26056742 HIST1H1C 0.51 7.67 0.39 2.02e-13 Height; CRC cis rs2153535 0.553 rs2984099 chr6:8637274 C/T cg21535247 chr6:8435926 SLC35B3 -0.66 -8.46 -0.42 9.16e-16 Motion sickness; CRC cis rs801193 1.000 rs17566701 chr7:66193183 T/C cg11764359 chr7:65958608 NA 0.53 8.05 0.41 1.51e-14 Aortic root size; CRC cis rs2576037 0.763 rs2060418 chr18:44576535 A/C cg07416455 chr18:44543612 TCEB3CL;KATNAL2 0.43 6.26 0.33 1.19e-9 Personality dimensions; CRC cis rs12681287 0.609 rs13281414 chr8:87495254 A/C cg27223183 chr8:87520930 FAM82B -0.53 -7.62 -0.39 2.64e-13 Caudate activity during reward; CRC cis rs863345 0.565 rs2051665 chr1:158507157 A/T cg12129480 chr1:158549410 OR10X1 -0.3 -6.17 -0.32 2.03e-9 Pneumococcal bacteremia; CRC cis rs7662987 0.517 rs1311618 chr4:100012612 A/G cg12011299 chr4:100065546 ADH4 0.49 9.16 0.45 5.61e-18 Smoking initiation; CRC cis rs10751667 1.000 rs7396366 chr11:986185 C/A ch.11.42038R chr11:967971 AP2A2 0.68 11.33 0.53 2.49e-25 Alzheimer's disease (late onset); CRC cis rs473651 0.935 rs477041 chr2:239355995 C/G cg18131467 chr2:239335373 ASB1 -1.0 -22.38 -0.78 4.59e-68 Multiple system atrophy; CRC cis rs2180341 0.814 rs9385424 chr6:127726796 A/G cg27446573 chr6:127587934 RNF146 0.7 9.61 0.47 1.95e-19 Breast cancer; CRC cis rs17767392 1.000 rs35621718 chr14:71780758 C/G cg13720639 chr14:72061746 SIPA1L1 -0.54 -6.9 -0.36 2.71e-11 Mitral valve prolapse; CRC trans rs6557786 0.636 rs17052934 chr8:24840319 A/C cg13324546 chr8:23564031 NKX2-6 -0.33 -5.98 -0.31 5.82e-9 Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 2 peripheral neuropathy); CRC cis rs708547 0.647 rs781666 chr4:57830981 A/G cg25525207 chr4:57843836 C4orf14;POLR2B -0.46 -6.38 -0.33 6.16e-10 Response to bleomycin (chromatid breaks); CRC cis rs72772090 0.539 rs72773932 chr5:96118148 T/C cg17330273 chr5:96107758 CAST;ERAP1 -0.63 -5.77 -0.3 1.79e-8 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs9858542 0.903 rs11917431 chr3:49644012 C/T cg07274523 chr3:49395745 GPX1 0.46 5.89 0.31 9.41e-9 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs9467711 0.591 rs13201821 chr6:26057781 A/C cg19084075 chr6:26124329 HIST1H2AC;HIST1H2BC 0.64 6.03 0.32 4.33e-9 Autism spectrum disorder or schizophrenia; CRC cis rs853679 0.517 rs868987 chr6:28110148 A/G cg03623178 chr6:28175578 NA -0.97 -12.97 -0.58 2.44e-31 Depression; CRC cis rs4363385 0.818 rs1591736 chr1:152987497 A/C cg25856811 chr1:152973957 SPRR3 -0.25 -7.1 -0.36 7.84e-12 Inflammatory skin disease; CRC cis rs9443645 0.901 rs1572584 chr6:79690290 A/G cg05283184 chr6:79620031 NA 0.56 8.77 0.44 1.01e-16 Intelligence (multi-trait analysis); CRC cis rs9649213 0.574 rs34717219 chr7:97962271 A/C cg21770322 chr7:97807741 LMTK2 0.51 8.33 0.42 2.26e-15 Prostate cancer (SNP x SNP interaction); CRC cis rs10256972 0.552 rs7805591 chr7:1210745 A/G cg03188948 chr7:1209495 NA 0.57 8.36 0.42 1.8e-15 Longevity;Endometriosis; CRC cis rs2408955 0.522 rs2051851 chr12:48485940 G/C cg15465823 chr12:48382534 COL2A1 -0.37 -6.14 -0.32 2.41e-9 Glycated hemoglobin levels; CRC cis rs7772486 0.624 rs9485018 chr6:146025731 T/C cg13319975 chr6:146136371 FBXO30 0.43 6.44 0.33 4.21e-10 Lobe attachment (rater-scored or self-reported); CRC cis rs2404602 0.716 rs17461634 chr15:76764107 G/A cg23625390 chr15:77176239 SCAPER 0.5 7.41 0.38 1.08e-12 Blood metabolite levels; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg01301935 chr16:69599904 NFAT5;MIR1538 0.48 6.17 0.32 2.03e-9 Thyroid stimulating hormone; CRC trans rs7267979 1.000 rs2482943 chr20:25380593 G/A cg17903999 chr18:56338584 MALT1 0.41 6.54 0.34 2.33e-10 Liver enzyme levels (alkaline phosphatase); CRC cis rs921968 0.643 rs522377 chr2:219437476 T/C cg02176678 chr2:219576539 TTLL4 0.49 7.88 0.4 4.73e-14 Mean corpuscular hemoglobin concentration; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg06498398 chr8:11627480 NEIL2 0.43 6.04 0.32 4.18e-9 Response to antipsychotic treatment; CRC cis rs9443645 0.869 rs7762022 chr6:79502859 C/A cg11833968 chr6:79620685 NA -0.35 -6.1 -0.32 2.98e-9 Intelligence (multi-trait analysis); CRC cis rs7223966 1.000 rs78172786 chr17:61847114 A/C cg23090583 chr17:61904693 PSMC5;FTSJ3 0.55 6.45 0.34 3.97e-10 Hip circumference adjusted for BMI;Body mass index; CRC cis rs11122272 0.735 rs2474633 chr1:231486989 A/C cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.5 -7.41 -0.38 1.05e-12 Hemoglobin concentration; CRC trans rs11764590 0.666 rs7787359 chr7:2090849 A/G cg11693508 chr17:37793320 STARD3 0.5 6.69 0.35 9.65e-11 Neuroticism; CRC trans rs6557786 0.636 rs17052934 chr8:24840319 A/C cg15944457 chr8:30891341 WRN;PURG 0.5 6.51 0.34 2.76e-10 Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 2 peripheral neuropathy); CRC cis rs7618915 0.501 rs34739010 chr3:52766122 A/G cg11645453 chr3:52864694 ITIH4 0.36 6.48 0.34 3.31e-10 Bipolar disorder; CRC cis rs7712401 0.686 rs154509 chr5:122198340 T/A cg18764291 chr5:122110994 SNX2 0.35 5.67 0.3 3.2e-8 Mean platelet volume; CRC cis rs1670533 1.000 rs6839931 chr4:1053172 A/G cg27284194 chr4:1044797 NA 0.49 6.11 0.32 2.88e-9 Recombination rate (females); CRC cis rs9549260 0.709 rs4581585 chr13:41203905 C/T cg21288729 chr13:41239152 FOXO1 0.49 7.68 0.39 1.88e-13 Red blood cell count; CRC cis rs637571 0.584 rs594689 chr11:65635559 G/A cg26695010 chr11:65641043 EFEMP2 0.56 9.01 0.44 1.68e-17 Eosinophil percentage of white cells; CRC trans rs7613875 0.578 rs2624822 chr3:50107219 T/C cg21659725 chr3:3221576 CRBN -0.46 -6.77 -0.35 6.01e-11 Body mass index; CRC trans rs4263408 0.934 rs9683743 chr4:39703194 A/C cg24201716 chr10:115933917 C10orf118;MIR2110 -0.42 -6.44 -0.33 4.17e-10 Plasma amyloid beta peptide concentrations (ABx-40); CRC cis rs889312 0.500 rs832570 chr5:56156408 G/A cg20203395 chr5:56204925 C5orf35 -0.4 -5.64 -0.3 3.69e-8 Breast cancer;Breast cancer (early onset); CRC cis rs3096299 0.503 rs4785677 chr16:89555101 A/G cg08392591 chr16:89556376 ANKRD11 0.48 6.51 0.34 2.85e-10 Multiple myeloma (IgH translocation); CRC cis rs7107174 0.688 rs10899501 chr11:78131408 C/T cg02023728 chr11:77925099 USP35 0.39 6.03 0.32 4.39e-9 Testicular germ cell tumor; CRC cis rs6502050 0.723 rs8077209 chr17:80163221 A/G cg13198984 chr17:80129470 CCDC57 0.35 5.93 0.31 7.55e-9 Life satisfaction; CRC cis rs7264396 0.563 rs2425116 chr20:34323553 T/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.49 -6.55 -0.34 2.15e-10 Total cholesterol levels; CRC cis rs3771570 0.901 rs4675964 chr2:242324760 A/C cg21155796 chr2:242212141 HDLBP 0.55 6.67 0.34 1.12e-10 Prostate cancer; CRC cis rs17270561 0.609 rs12663099 chr6:25739518 C/T cg16482183 chr6:26056742 HIST1H1C 0.83 10.58 0.5 1.07e-22 Iron status biomarkers; CRC cis rs9494145 0.680 rs11759553 chr6:135422296 A/T cg22676075 chr6:135203613 NA 0.48 6.32 0.33 8.73e-10 Mean platelet volume;Platelet count;Fetal hemoglobin levels in sickle cell anemia;Red blood cell traits; CRC cis rs748404 0.697 rs493177 chr15:43543258 A/C cg02155558 chr15:43621948 ADAL;LCMT2 0.4 5.94 0.31 7.14e-9 Lung cancer; CRC cis rs4665809 0.887 rs4665814 chr2:26273687 G/T cg22920501 chr2:26401640 FAM59B -0.49 -6.87 -0.35 3.31e-11 Gut microbiome composition (summer); CRC cis rs12497850 1.000 rs6788650 chr3:48749543 T/C cg07636037 chr3:49044803 WDR6 0.93 15.77 0.66 3.98e-42 Parkinson's disease; CRC trans rs951252 0.504 rs11734405 chr4:146081096 C/T cg15216925 chr5:179921655 CNOT6 0.5 6.95 0.36 1.93e-11 Hip circumference; CRC cis rs9648716 0.554 rs4726020 chr7:140603652 A/G cg17554604 chr7:140774522 NA 0.44 5.96 0.31 6.32e-9 Type 2 diabetes; CRC cis rs4713118 0.527 rs35949862 chr6:28115367 A/G cg12963246 chr6:28129442 ZNF389 0.49 5.7 0.3 2.71e-8 Parkinson's disease; CRC cis rs801193 0.839 rs12534943 chr7:66070520 A/G cg11764359 chr7:65958608 NA -0.5 -7.63 -0.39 2.51e-13 Aortic root size; CRC cis rs4423214 0.840 rs1790343 chr11:71177207 T/C cg13043300 chr11:71146211 DHCR7 -0.44 -5.91 -0.31 8.58e-9 Vitamin D levels; CRC cis rs1355223 0.506 rs7130678 chr11:34869181 A/G cg11058730 chr11:34937778 PDHX;APIP -0.42 -5.81 -0.31 1.48e-8 Systemic lupus erythematosus and Systemic sclerosis; CRC cis rs881375 1.000 rs1953126 chr9:123640500 T/C cg09586646 chr9:123605570 PSMD5;LOC253039 0.52 7.1 0.36 7.81e-12 Rheumatoid arthritis; CRC cis rs11098499 0.739 rs2203039 chr4:120132347 T/C cg24375607 chr4:120327624 NA -0.46 -7.71 -0.39 1.52e-13 Corneal astigmatism; CRC cis rs1018836 0.818 rs715057 chr8:91624340 T/C cg16814680 chr8:91681699 NA -0.76 -12.56 -0.57 7.88e-30 Ejection fraction in Tripanosoma cruzi seropositivity; CRC cis rs11255291 1.000 rs7917456 chr10:7732323 A/G cg00997801 chr10:7671259 ITIH5 0.4 5.79 0.3 1.63e-8 Ovarian reserve; CRC cis rs2839186 0.770 rs2280956 chr21:47642323 C/G cg13012494 chr21:47604986 C21orf56 -0.43 -6.85 -0.35 3.63e-11 Testicular germ cell tumor; CRC trans rs12478296 1.000 rs55814222 chr2:243041166 C/T cg18288967 chr1:45987694 PRDX1 0.68 7.48 0.38 6.93e-13 Obesity-related traits; CRC cis rs9929218 0.501 rs12448999 chr16:68815549 T/A cg01251360 chr16:68772225 CDH1 -0.23 -5.63 -0.3 3.88e-8 Colorectal cancer; CRC cis rs2153535 0.580 rs4404802 chr6:8442052 A/G cg21535247 chr6:8435926 SLC35B3 0.48 7.24 0.37 3.19e-12 Motion sickness; CRC cis rs3736485 0.934 rs882385 chr15:51882369 C/T cg08986416 chr15:51914746 DMXL2 -0.46 -6.56 -0.34 2.11e-10 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC trans rs11026407 0.967 rs7127246 chr11:22060228 C/G cg11477977 chr8:29952662 LEPROTL1 -0.56 -6.06 -0.32 3.8e-9 Plasma thyroid-stimulating hormone levels; CRC cis rs870825 0.616 rs28375770 chr4:185647395 C/T cg04058563 chr4:185651563 MLF1IP 0.72 9.3 0.46 2.04e-18 Blood protein levels; CRC cis rs798554 0.610 rs2527696 chr7:2858315 T/C cg19717773 chr7:2847554 GNA12 -0.47 -8.02 -0.4 1.89e-14 Height; CRC cis rs1005277 0.579 rs1780137 chr10:38501475 C/G cg00409905 chr10:38381863 ZNF37A -0.64 -10.34 -0.5 6.76e-22 Extrinsic epigenetic age acceleration; CRC cis rs4908768 0.539 rs6675443 chr1:8651582 T/A cg20416874 chr1:8611966 RERE -0.42 -5.89 -0.31 9.7e-9 Neuroticism (multi-trait analysis);Subjective well-being (multi-trait analysis); CRC trans rs8073060 0.586 rs2626625 chr17:34027607 C/G cg19694781 chr19:47549865 TMEM160 -1.08 -14.76 -0.63 3.56e-38 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; CRC cis rs6456156 0.774 rs968333 chr6:167526198 A/T cg07513332 chr6:167530253 CCR6 0.41 7.33 0.37 1.77e-12 Primary biliary cholangitis; CRC cis rs9549328 0.565 rs35988856 chr13:113617427 T/C cg17524180 chr13:113633600 MCF2L 0.52 9.5 0.46 4.44e-19 Systolic blood pressure; CRC cis rs2921036 0.529 rs2979192 chr8:8338147 C/T cg06636001 chr8:8085503 FLJ10661 0.56 8.26 0.41 3.55e-15 Neuroticism; CRC cis rs612683 0.862 rs12760924 chr1:100898600 A/T cg06223162 chr1:101003688 GPR88 0.32 5.7 0.3 2.74e-8 Breast cancer; CRC cis rs10540 1.000 rs78520676 chr11:517173 G/A cg21784768 chr11:537496 LRRC56 -0.7 -6.63 -0.34 1.39e-10 Body mass index; CRC trans rs3780486 1.000 rs10813951 chr9:33128021 C/T cg04842962 chr6:43655489 MRPS18A -0.99 -15.55 -0.65 3.02e-41 IgG glycosylation; CRC cis rs10927875 0.864 rs12744578 chr1:16173110 A/T cg21385522 chr1:16154831 NA -0.9 -11.47 -0.53 7.58e-26 Dilated cardiomyopathy; CRC trans rs3780486 0.505 rs10117038 chr9:33122626 T/C cg20290983 chr6:43655470 MRPS18A 0.93 17.17 0.69 1.26e-47 IgG glycosylation; CRC cis rs2386661 0.826 rs2386651 chr10:5678031 C/A cg26603656 chr10:5671107 NA 0.56 9.26 0.45 2.69e-18 Breast cancer; CRC trans rs1814175 0.645 rs7928714 chr11:49887622 G/A cg03929089 chr4:120376271 NA -0.9 -15.52 -0.65 3.9e-41 Height; CRC cis rs9462027 0.628 rs28675115 chr6:34732514 G/A cg07306190 chr6:34760872 UHRF1BP1 -0.35 -6.25 -0.33 1.28e-9 Systemic lupus erythematosus; CRC cis rs2070488 0.965 rs6599206 chr3:38545349 C/T cg01465620 chr3:38496096 LOC100128640;ACVR2B -0.91 -16.99 -0.68 6.53e-47 Electrocardiographic conduction measures; CRC cis rs2811415 0.597 rs9858267 chr3:127786551 G/A cg13719885 chr3:127795394 NA -0.39 -5.95 -0.31 6.69e-9 Lung function (FEV1/FVC); CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg12317151 chr18:3012764 LPIN2 0.46 6.25 0.33 1.28e-9 Anxiety disorder; CRC cis rs9311676 0.656 rs55692656 chr3:58383174 A/T cg06643156 chr3:58380774 PXK 0.4 6.3 0.33 9.47e-10 Systemic lupus erythematosus; CRC cis rs754466 0.651 rs11002316 chr10:79617511 C/G cg17075019 chr10:79541650 NA -0.89 -15.36 -0.65 1.55e-40 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs7771547 0.519 rs6923337 chr6:36369260 C/T cg07856975 chr6:36356162 ETV7 0.45 5.64 0.3 3.62e-8 Platelet distribution width; CRC cis rs3751196 0.901 rs117907031 chr12:104184317 G/C cg02344784 chr12:104178138 NT5DC3 0.69 7.07 0.36 9.08e-12 Sense of smell; CRC cis rs1801251 0.963 rs66549961 chr2:233602293 A/G cg25237894 chr2:233734115 C2orf82 0.54 8.78 0.44 9.04e-17 Coronary artery disease; CRC cis rs11098499 0.954 rs7436506 chr4:120393769 T/C cg24375607 chr4:120327624 NA 0.49 7.62 0.39 2.77e-13 Corneal astigmatism; CRC cis rs13256369 0.708 rs10903310 chr8:8589687 A/C cg18904891 chr8:8559673 CLDN23 -0.6 -8.29 -0.42 2.83e-15 Obesity-related traits; CRC cis rs2839186 0.656 rs8128380 chr21:47665693 C/T cg13126279 chr21:47581558 C21orf56 -0.38 -5.61 -0.3 4.21e-8 Testicular germ cell tumor; CRC cis rs950169 0.810 rs62029594 chr15:84955252 T/C cg11189052 chr15:85197271 WDR73 0.63 8.8 0.44 7.65e-17 Schizophrenia; CRC cis rs2280018 1.000 rs2280018 chr16:15150833 A/C cg27102117 chr16:15229624 NA 0.39 6.78 0.35 5.55e-11 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid);Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CRC cis rs55794721 0.509 rs6699113 chr1:25777743 C/T cg20684491 chr1:25596433 NA 0.45 7.96 0.4 2.75e-14 Plateletcrit;Mean corpuscular volume; CRC cis rs35362007 0.530 rs10484053 chr14:96011645 C/T cg02940042 chr14:96000874 GLRX5;SNHG10;SCARNA13 0.65 5.79 0.3 1.64e-8 Mean corpuscular volume;Mean corpuscular hemoglobin; CRC cis rs2303759 0.709 rs8102658 chr19:49828855 C/T cg22133161 chr19:49891603 CCDC155 0.52 6.65 0.34 1.22e-10 Multiple sclerosis; CRC cis rs12893668 0.572 rs1606 chr14:104161281 G/A cg08213375 chr14:104286397 PPP1R13B 0.46 7.37 0.38 1.42e-12 Reticulocyte count; CRC cis rs7737355 0.812 rs2042252 chr5:130980027 A/G cg25547332 chr5:131281432 NA -0.36 -5.75 -0.3 1.99e-8 Life satisfaction; CRC cis rs1150668 0.796 rs1124132 chr6:28380321 T/G cg03623178 chr6:28175578 NA 0.58 8.66 0.43 2.08e-16 Pubertal anthropometrics; CRC cis rs10751667 0.666 rs10902249 chr11:958566 C/T cg06064525 chr11:970664 AP2A2 0.33 6.67 0.35 1.08e-10 Alzheimer's disease (late onset); CRC cis rs10504073 0.584 rs62507178 chr8:49938572 A/C cg00325661 chr8:49890786 NA 0.6 10.82 0.51 1.48e-23 Blood metabolite ratios; CRC cis rs597539 0.652 rs668576 chr11:68668208 A/G cg06112835 chr11:68658793 MRPL21 0.48 7.67 0.39 2e-13 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg02674588 chr19:17982716 SLC5A5 0.45 7.48 0.38 6.65e-13 Intelligence (multi-trait analysis); CRC cis rs11622475 1.000 rs12889168 chr14:104481957 A/T cg20488157 chr14:104394430 TDRD9 0.67 9.54 0.47 3.45e-19 Bipolar disorder; CRC cis rs9649213 0.533 rs1541409 chr7:98027580 C/T cg09267113 chr7:98030324 BAIAP2L1 -0.94 -12.38 -0.56 3.69e-29 Prostate cancer (SNP x SNP interaction); CRC cis rs589448 0.902 rs642786 chr12:69758462 T/C cg22834771 chr12:69754056 YEATS4 -0.56 -8.68 -0.43 1.93e-16 Cerebrospinal fluid biomarker levels; CRC cis rs1552244 0.554 rs17050704 chr3:10045734 T/C cg13047869 chr3:10149882 C3orf24 0.38 5.93 0.31 7.73e-9 Alzheimer's disease; CRC cis rs9303280 0.870 rs1011082 chr17:38068514 T/C cg20243544 chr17:37824526 PNMT -0.42 -6.47 -0.34 3.47e-10 Self-reported allergy; CRC cis rs806215 0.826 rs712699 chr7:127250597 G/A cg25922125 chr7:127225783 GCC1 0.57 6.29 0.33 1.02e-9 Type 2 diabetes; CRC cis rs10493773 0.630 rs3753790 chr1:86174772 T/C cg23216685 chr1:86174607 ZNHIT6 -0.29 -6.84 -0.35 3.77e-11 Urate levels in overweight individuals; CRC cis rs6502050 0.835 rs66531647 chr17:80089022 G/T cg25804541 chr17:80189381 SLC16A3 -0.3 -5.84 -0.31 1.24e-8 Life satisfaction; CRC cis rs6754311 0.731 rs2322660 chr2:136557319 A/G cg15123519 chr2:136567270 LCT -0.32 -6.26 -0.33 1.23e-9 Mosquito bite size; CRC cis rs3741151 0.764 rs73548680 chr11:73271335 T/C cg17517138 chr11:73019481 ARHGEF17 0.96 7.44 0.38 9.11e-13 GIP levels in response to oral glucose tolerance test (120 minutes); CRC cis rs72634258 0.554 rs12092614 chr1:7865710 C/T cg26816564 chr1:7831052 VAMP3 0.82 9.27 0.46 2.54e-18 Inflammatory bowel disease; CRC cis rs9640161 0.789 rs28439010 chr7:150046276 C/T cg13722127 chr7:150037890 RARRES2 0.41 6.21 0.32 1.56e-9 Blood protein levels;Circulating chemerin levels; CRC trans rs10504229 1.000 rs66796009 chr8:58174529 G/A cg04077850 chr5:125800366 GRAMD3 0.37 6.25 0.33 1.26e-9 Developmental language disorder (linguistic errors); CRC cis rs3806843 0.900 rs2563287 chr5:140124786 C/T cg16607685 chr5:140181889 PCDHA2;PCDHA1;PCDHA3 -0.25 -5.97 -0.31 6.06e-9 Depressive symptoms (multi-trait analysis); CRC cis rs13108904 0.870 rs13124876 chr4:1247955 T/C cg19318889 chr4:1322082 MAEA 0.4 5.9 0.31 8.95e-9 Obesity-related traits; CRC cis rs4713118 0.869 rs9283883 chr6:27715470 T/A cg15786705 chr6:28176104 NA 0.58 8.04 0.41 1.6e-14 Parkinson's disease; CRC cis rs55665837 1.000 rs11023215 chr11:14436970 C/T cg19336497 chr11:14380999 RRAS2 -0.42 -7.12 -0.37 6.88e-12 Vitamin D levels; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg26277809 chr12:9102068 M6PR 0.44 6.44 0.33 4.25e-10 Intelligence (multi-trait analysis); CRC cis rs61008539 0.893 rs11765528 chr7:861952 C/T cg07138768 chr7:917805 C7orf20 0.3 5.77 0.3 1.8e-8 Perceived unattractiveness to mosquitoes; CRC cis rs16975963 0.644 rs11083428 chr19:38083967 A/C cg15135657 chr19:38346511 NA -0.46 -6.28 -0.33 1.06e-9 Longevity; CRC cis rs561341 0.941 rs2428338 chr17:30299629 T/C cg00745463 chr17:30367425 LRRC37B -0.7 -8.49 -0.42 7.09e-16 Hip circumference adjusted for BMI; CRC cis rs7829975 0.564 rs2921060 chr8:8317817 G/T cg06636001 chr8:8085503 FLJ10661 -0.71 -10.37 -0.5 5.46e-22 Mood instability; CRC cis rs600806 0.850 rs11102981 chr1:109967323 G/C cg23032129 chr1:109941072 SORT1 -0.29 -6.02 -0.31 4.78e-9 Intelligence (multi-trait analysis); CRC cis rs7901135 0.962 rs1899979 chr10:60580635 A/G cg23799393 chr10:60588674 BICC1 0.37 5.7 0.3 2.73e-8 Morning vs. evening chronotype; CRC cis rs6674970 0.933 rs12134957 chr1:151045419 A/G cg03258749 chr1:151040405 MLLT11 -0.48 -7.45 -0.38 8.03e-13 Childhood ear infection; CRC trans rs2303319 0.504 rs62187609 chr2:162431500 C/T cg20397358 chr22:38597902 MAFF -0.73 -6.01 -0.31 4.9e-9 Cognitive function; CRC cis rs4481887 0.708 rs28729425 chr1:248563027 T/C cg26353448 chr1:248524236 OR2T4 -0.3 -5.68 -0.3 2.91e-8 Common traits (Other); CRC cis rs4332037 0.539 rs868754 chr7:2033780 G/C cg21155852 chr7:2048760 MAD1L1 -0.55 -6.99 -0.36 1.54e-11 Bipolar disorder; CRC cis rs6977660 0.507 rs72591449 chr7:19775443 T/C cg07541023 chr7:19748670 TWISTNB 0.79 7.35 0.38 1.56e-12 Thyroid stimulating hormone; CRC cis rs2204008 0.837 rs11169157 chr12:37980047 T/C cg13010199 chr12:38710504 ALG10B 0.46 6.1 0.32 3.03e-9 Bladder cancer; CRC cis rs473651 0.716 rs548179 chr2:239320505 G/A cg18131467 chr2:239335373 ASB1 0.94 18.94 0.72 1.24e-54 Multiple system atrophy; CRC cis rs2933343 0.700 rs6787833 chr3:128656184 A/G cg11901034 chr3:128598214 ACAD9 -0.57 -8.27 -0.41 3.3e-15 IgG glycosylation; CRC cis rs1403694 0.515 rs1624569 chr3:186450069 A/G cg04611788 chr3:186434169 KNG1 -0.53 -7.7 -0.39 1.64e-13 Blood protein levels; CRC trans rs11098499 0.908 rs28499576 chr4:120386677 G/A cg25214090 chr10:38739885 LOC399744 0.66 10.5 0.5 1.96e-22 Corneal astigmatism; CRC cis rs6912958 0.712 rs2246113 chr6:88410050 C/T cg12350822 chr6:88032061 C6orf162;GJB7 -0.33 -6.11 -0.32 2.77e-9 Monocyte percentage of white cells; CRC cis rs6433857 0.505 rs12471899 chr2:181369856 C/T cg23363182 chr2:181467187 NA -0.55 -8.01 -0.4 2.01e-14 Body mass index; CRC cis rs3790455 0.610 rs1171563 chr1:156456529 T/G cg14087168 chr1:156450669 MEF2D -0.37 -6.03 -0.32 4.45e-9 Migraine; CRC cis rs2380220 0.541 rs72928273 chr6:96079360 C/T cg04719120 chr6:96025338 MANEA -0.74 -9.08 -0.45 1.03e-17 Behavioural disinhibition (generation interaction); CRC cis rs10189230 0.967 rs13002861 chr2:222352859 T/G cg14652038 chr2:222343519 EPHA4 0.52 10.09 0.49 4.79e-21 Urate levels in lean individuals; CRC trans rs561341 0.941 rs17780086 chr17:30343282 G/A cg20587970 chr11:113659929 NA -1.43 -20.05 -0.74 5.67e-59 Hip circumference adjusted for BMI; CRC cis rs9611565 0.512 rs5758465 chr22:42175314 T/C cg17554472 chr22:41940697 POLR3H 0.56 5.76 0.3 1.93e-8 Vitiligo; CRC cis rs832540 0.656 rs6893754 chr5:56100006 G/A cg12311346 chr5:56204834 C5orf35 -0.49 -7.34 -0.38 1.64e-12 Coronary artery disease; CRC trans rs7726839 0.574 rs11134148 chr5:637107 C/T cg11887960 chr12:57824829 NA 0.59 6.57 0.34 2e-10 Obesity-related traits; CRC cis rs6088580 0.634 rs6059835 chr20:33020141 A/G cg24642439 chr20:33292090 TP53INP2 0.36 6.12 0.32 2.65e-9 Glomerular filtration rate (creatinine); CRC trans rs1997103 1.000 rs10278894 chr7:55404748 A/G cg20935933 chr6:143382018 AIG1 0.51 6.68 0.35 1.03e-10 QRS interval (sulfonylurea treatment interaction); CRC cis rs17270561 0.636 rs77343532 chr6:25828828 G/A cg16482183 chr6:26056742 HIST1H1C 0.68 9.08 0.45 1.05e-17 Iron status biomarkers; CRC cis rs6674970 1.000 rs6656450 chr1:151089602 A/T cg03258749 chr1:151040405 MLLT11 -0.48 -7.29 -0.37 2.33e-12 Childhood ear infection; CRC cis rs9914988 0.943 rs2043031 chr17:27085564 A/G cg20469991 chr17:27169893 C17orf63 -0.61 -7.29 -0.37 2.32e-12 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs734999 0.545 rs28690427 chr1:2571823 A/G cg18854424 chr1:2615690 NA -0.41 -7.67 -0.39 1.97e-13 Ulcerative colitis; CRC cis rs2380220 0.574 rs7766765 chr6:95997362 G/A cg04719120 chr6:96025338 MANEA 0.52 6.41 0.33 5.19e-10 Behavioural disinhibition (generation interaction); CRC cis rs4731207 0.564 rs10279816 chr7:124581580 T/C cg23710748 chr7:124431027 NA -0.38 -6.08 -0.32 3.25e-9 Cutaneous malignant melanoma; CRC cis rs311392 0.934 rs376589 chr8:55088289 G/A cg06042504 chr8:55087323 NA -0.43 -6.52 -0.34 2.57e-10 Pelvic organ prolapse (moderate/severe); CRC cis rs6089584 0.927 rs2296083 chr20:60574216 C/T cg13770153 chr20:60521292 NA -0.57 -9.58 -0.47 2.42e-19 Body mass index; CRC cis rs1580019 0.922 rs34545272 chr7:32460630 C/T cg07520158 chr7:32535189 LSM5;AVL9 0.44 5.97 0.31 6.04e-9 Cognitive ability; CRC cis rs9894429 0.505 rs35570626 chr17:79611084 A/G cg21984481 chr17:79567631 NPLOC4 -0.44 -7.6 -0.39 3.18e-13 Eye color traits; CRC cis rs7580658 0.929 rs4150496 chr2:128029503 C/T cg09760422 chr2:128146352 NA -0.36 -7.1 -0.36 7.68e-12 Protein C levels; CRC cis rs9322193 0.926 rs9383546 chr6:150143879 T/A cg13206674 chr6:150067644 NUP43 0.56 7.82 0.4 7.02e-14 Lung cancer; CRC cis rs826838 0.900 rs9739128 chr12:38948960 A/T cg13010199 chr12:38710504 ALG10B 0.44 5.81 0.31 1.48e-8 Heart rate; CRC cis rs11212617 0.934 rs11212551 chr11:108078693 G/T cg01991180 chr11:108092276 ATM;NPAT 0.45 6.72 0.35 8e-11 Response to metformin in type 2 diabetes (glycemic); CRC cis rs10927875 0.631 rs945418 chr1:16344730 T/C cg24140574 chr1:16342155 HSPB7 0.44 5.84 0.31 1.27e-8 Dilated cardiomyopathy; CRC cis rs3790844 0.678 rs3790854 chr1:200000125 C/T cg07208853 chr1:200005219 NR5A2 -0.34 -8.82 -0.44 6.83e-17 Pancreatic cancer; CRC cis rs9486719 1.000 rs13208422 chr6:96892119 C/T cg06623918 chr6:96969491 KIAA0776 -0.81 -9.51 -0.46 4.17e-19 Migraine;Coronary artery disease; CRC cis rs6582630 0.519 rs1607882 chr12:38361657 G/A cg13010199 chr12:38710504 ALG10B 0.47 6.6 0.34 1.64e-10 Drug-induced liver injury (flucloxacillin); CRC cis rs1506636 0.886 rs6466878 chr7:123272278 T/C cg03229431 chr7:123269106 ASB15 -0.83 -13.58 -0.6 1.16e-33 Plateletcrit;Platelet count; CRC cis rs10883723 0.810 rs2296589 chr10:104248106 T/A cg04362960 chr10:104952993 NT5C2 -0.43 -6.01 -0.31 4.81e-9 Allergic disease (asthma, hay fever or eczema); CRC cis rs1005277 0.579 rs2504140 chr10:38387579 T/G cg25517755 chr10:38738941 LOC399744 -0.44 -6.41 -0.33 5.05e-10 Extrinsic epigenetic age acceleration; CRC cis rs1150668 0.796 rs9468372 chr6:28379361 T/A cg03623178 chr6:28175578 NA 0.49 7.12 0.37 6.89e-12 Pubertal anthropometrics; CRC cis rs12893668 0.572 rs7148857 chr14:104143237 C/G cg24130564 chr14:104152367 KLC1 -0.42 -5.63 -0.3 3.82e-8 Reticulocyte count; CRC cis rs2839186 0.708 rs6518285 chr21:47644667 T/C cg13012494 chr21:47604986 C21orf56 0.46 7.31 0.37 2.04e-12 Testicular germ cell tumor; CRC cis rs17345786 0.906 rs11710016 chr3:101120030 A/C cg03837452 chr3:101395095 ZBTB11;LOC100009676 -0.58 -6.59 -0.34 1.74e-10 Colonoscopy-negative controls vs population controls; CRC cis rs3736485 0.966 rs11070852 chr15:51782294 G/T cg08986416 chr15:51914746 DMXL2 -0.44 -6.18 -0.32 1.91e-9 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs6952808 0.789 rs35729895 chr7:1885069 C/T cg04267008 chr7:1944627 MAD1L1 -0.65 -9.52 -0.46 4e-19 Bipolar disorder and schizophrenia; CRC cis rs10883723 0.810 rs7069356 chr10:104254359 G/C cg11453585 chr10:104263688 ACTR1A;SUFU 0.92 17.58 0.7 2.89e-49 Allergic disease (asthma, hay fever or eczema); CRC cis rs9308731 0.583 rs10211562 chr2:111930796 G/T cg04202892 chr2:111875749 ACOXL 0.42 6.62 0.34 1.44e-10 Chronic lymphocytic leukemia; CRC cis rs6662572 0.737 rs4660887 chr1:46275959 A/G cg08644498 chr1:46502608 NA -0.44 -7.0 -0.36 1.4e-11 Blood protein levels; CRC cis rs4888262 0.508 rs7189123 chr16:74540097 C/A cg01733217 chr16:74700730 RFWD3 0.75 11.24 0.53 4.86e-25 Testicular germ cell tumor; CRC cis rs72772090 0.539 rs11748519 chr5:96119328 C/A cg17330273 chr5:96107758 CAST;ERAP1 -0.63 -5.77 -0.3 1.79e-8 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs860295 0.629 rs12026638 chr1:155401260 T/C cg02153340 chr1:155202674 NA -0.58 -6.85 -0.35 3.57e-11 Body mass index; CRC cis rs28386778 0.799 rs2665836 chr17:61898135 C/A cg23090583 chr17:61904693 PSMC5;FTSJ3 1.05 20.2 0.74 1.38e-59 Prudent dietary pattern; CRC cis rs7208859 0.623 rs9911997 chr17:29124648 A/G cg13385521 chr17:29058706 SUZ12P 0.74 8.44 0.42 9.97e-16 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs910187 0.537 rs1417452 chr20:45763350 T/C cg27589058 chr20:45804311 EYA2 -0.36 -6.48 -0.34 3.26e-10 Migraine; CRC trans rs2727020 0.688 rs11040338 chr11:49360601 A/G cg15704280 chr7:45808275 SEPT13 0.89 16.24 0.67 6.02e-44 Coronary artery disease; CRC cis rs6921919 0.515 rs1558205 chr6:28382262 A/C cg06470822 chr6:28175283 NA -0.43 -5.93 -0.31 7.6e-9 Autism spectrum disorder or schizophrenia; CRC cis rs10504229 0.683 rs56204590 chr8:58131642 T/G cg22535103 chr8:58192502 C8orf71 -0.7 -9.34 -0.46 1.47e-18 Developmental language disorder (linguistic errors); CRC cis rs4665809 0.590 rs1560865 chr2:26452197 C/A cg22920501 chr2:26401640 FAM59B -0.85 -12.62 -0.57 4.71e-30 Gut microbiome composition (summer); CRC cis rs6541297 1.000 rs6665367 chr1:230279169 G/A cg20703242 chr1:230279135 GALNT2 0.51 8.0 0.4 2.21e-14 Coronary artery disease; CRC cis rs995000 0.868 rs1168113 chr1:63156098 T/C cg19896129 chr1:63156450 NA -0.45 -6.85 -0.35 3.72e-11 Triglyceride levels; CRC trans rs1005277 0.602 rs1780141 chr10:38504299 T/C cg11292332 chr7:45801988 SEPT13 -0.38 -7.02 -0.36 1.26e-11 Extrinsic epigenetic age acceleration; CRC cis rs7666738 0.791 rs11729596 chr4:99045461 A/G cg17366294 chr4:99064904 C4orf37 0.45 7.73 0.39 1.34e-13 Colonoscopy-negative controls vs population controls; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg03387256 chr10:90750898 FAS;ACTA2 0.47 6.55 0.34 2.28e-10 Response to antipsychotic treatment; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg24031606 chr3:48229318 CDC25A 0.44 6.09 0.32 3.16e-9 Response to antipsychotic treatment; CRC cis rs1552244 0.882 rs6443279 chr3:10053599 C/A cg13047869 chr3:10149882 C3orf24 0.53 7.05 0.36 1.03e-11 Alzheimer's disease; CRC cis rs7945705 0.747 rs1980428 chr11:9010497 A/G cg14711859 chr11:8959438 ASCL3 -0.34 -5.76 -0.3 1.98e-8 Hemoglobin concentration; CRC cis rs9787249 0.874 rs7520588 chr1:40214525 T/A cg01941586 chr1:40203715 PPIE -0.45 -6.21 -0.32 1.59e-9 Blood protein levels; CRC trans rs875971 0.660 rs2191268 chr7:66110224 C/T cg04328701 chr17:40761179 FAM134C;TUBG1 -0.41 -6.28 -0.33 1.08e-9 Aortic root size; CRC cis rs10927875 0.518 rs732286 chr1:16344360 A/G cg10494257 chr1:16342123 HSPB7 0.46 6.38 0.33 6.02e-10 Dilated cardiomyopathy; CRC cis rs9902453 0.904 rs12951836 chr17:28410277 A/G cg26525008 chr17:28256777 EFCAB5;SSH2 -0.73 -12.33 -0.56 5.77e-29 Coffee consumption (cups per day); CRC cis rs13191362 1.000 rs66594243 chr6:163169024 T/C cg21926612 chr6:163149169 PACRG;PARK2 0.97 12.65 0.57 3.58e-30 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs55823223 0.646 rs55868394 chr17:73851113 C/A cg02397686 chr17:73851076 WBP2 0.75 6.28 0.33 1.07e-9 Psoriasis; CRC cis rs79349575 0.783 rs12601955 chr17:47034420 C/T cg22482690 chr17:47019901 SNF8 0.5 8.19 0.41 5.69e-15 Type 2 diabetes; CRC cis rs3091242 0.934 rs686631 chr1:25719599 A/T cg20684491 chr1:25596433 NA 0.38 6.59 0.34 1.8e-10 Erythrocyte sedimentation rate; CRC cis rs12908161 0.960 rs11633450 chr15:85307287 C/T cg17507749 chr15:85114479 UBE2QP1 0.6 8.42 0.42 1.17e-15 Schizophrenia; CRC cis rs2153535 0.601 rs2015281 chr6:8539673 G/A cg21535247 chr6:8435926 SLC35B3 0.5 7.72 0.39 1.45e-13 Motion sickness; CRC cis rs9611519 0.828 rs28814423 chr22:41452301 G/A cg03806693 chr22:41940476 POLR3H -0.58 -7.4 -0.38 1.17e-12 Neuroticism; CRC trans rs12663356 0.528 rs9350359 chr6:21462624 C/T cg08322149 chr10:46222875 FAM21C 0.41 6.02 0.31 4.6e-9 Crohn's disease; CRC cis rs652260 0.819 rs55656533 chr19:7902976 G/C cg26014689 chr19:7917955 EVI5L -0.53 -8.65 -0.43 2.27e-16 Menarche (age at onset); CRC cis rs10911232 0.507 rs10797832 chr1:183044034 A/G ch.1.3577855R chr1:183094577 LAMC1 0.82 13.91 0.61 6.75e-35 Hypertriglyceridemia; CRC cis rs1865760 0.623 rs12216125 chr6:25997458 C/T cg16482183 chr6:26056742 HIST1H1C 0.6 8.31 0.42 2.49e-15 Height; CRC cis rs9814567 0.752 rs4955544 chr3:134332776 T/A cg06109529 chr3:134205091 CEP63;ANAPC13 -0.67 -9.6 -0.47 2.04e-19 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC trans rs2018683 0.745 rs917217 chr7:28975025 G/T cg19402173 chr7:128379420 CALU 0.47 6.74 0.35 7.16e-11 Response to irinotecan and platinum-based chemotherapy in non-small-cell lung cancer; CRC cis rs13412757 0.646 rs184706 chr2:8457497 A/G cg12167548 chr2:8464763 NA 0.35 6.59 0.34 1.79e-10 Asthma;Itch intensity from mosquito bite adjusted by bite size; CRC cis rs2811415 0.627 rs9820691 chr3:127750866 A/G cg13719885 chr3:127795394 NA -0.39 -5.99 -0.31 5.56e-9 Lung function (FEV1/FVC); CRC cis rs9560113 0.843 rs9555808 chr13:112181284 A/T cg10483660 chr13:112241077 NA 0.36 5.78 0.3 1.76e-8 Menarche (age at onset); CRC cis rs11098499 0.570 rs6832740 chr4:120546136 T/C cg24375607 chr4:120327624 NA 0.49 7.67 0.39 1.91e-13 Corneal astigmatism; CRC cis rs3018066 0.867 rs10017969 chr4:107054085 C/T cg01869342 chr4:106983673 TBCK 0.37 5.7 0.3 2.61e-8 Cancer; CRC cis rs896854 0.654 rs4735337 chr8:95973465 T/C cg23172400 chr8:95962367 TP53INP1 -0.48 -8.17 -0.41 6.79e-15 Type 2 diabetes; CRC cis rs2072510 0.643 rs2367755 chr12:96393082 T/C cg09636302 chr12:96389483 HAL -0.45 -6.34 -0.33 7.43e-10 Metabolite levels (small molecules and protein measures); CRC cis rs1448094 0.512 rs7313278 chr12:86250263 C/T cg19622623 chr12:86230825 RASSF9 -0.41 -6.76 -0.35 6.45e-11 Major depressive disorder; CRC trans rs9467711 1.000 rs9467707 chr6:26327905 G/C cg15845792 chr6:28175446 NA 0.66 6.42 0.33 4.88e-10 Autism spectrum disorder or schizophrenia; CRC cis rs10504229 0.775 rs17216236 chr8:58159352 G/A cg20607798 chr8:58055168 NA 0.46 5.71 0.3 2.58e-8 Developmental language disorder (linguistic errors); CRC cis rs9443645 0.527 rs9352663 chr6:79558164 T/C cg09184832 chr6:79620586 NA -0.46 -8.03 -0.4 1.7e-14 Intelligence (multi-trait analysis); CRC cis rs12594515 1.000 rs8039622 chr15:45986431 A/G cg06207120 chr15:45996521 NA 0.32 7.7 0.39 1.59e-13 Waist circumference;Weight; CRC cis rs10771431 0.597 rs3759275 chr12:9353828 A/T cg08997352 chr12:9597637 DDX12 -0.45 -6.69 -0.35 9.48e-11 Breast size; CRC cis rs7666738 0.830 rs34916200 chr4:98851593 C/T cg17366294 chr4:99064904 C4orf37 0.41 6.67 0.35 1.08e-10 Colonoscopy-negative controls vs population controls; CRC cis rs12291225 0.546 rs12291662 chr11:14342949 T/C cg05501817 chr11:14380813 RRAS2 -0.47 -6.5 -0.34 2.97e-10 Sense of smell; CRC cis rs17401966 0.522 rs7368073 chr1:10314962 G/T cg19773385 chr1:10388646 KIF1B -0.48 -7.56 -0.38 4.13e-13 Hepatocellular carcinoma; CRC cis rs798554 0.679 rs1636254 chr7:2885724 T/C cg19717773 chr7:2847554 GNA12 -0.43 -6.12 -0.32 2.59e-9 Height; CRC cis rs2276314 0.857 rs8087539 chr18:33631537 C/T cg19628046 chr18:33552617 C18orf21 0.56 7.84 0.4 6.53e-14 Endometriosis;Drug-induced torsades de pointes; CRC cis rs9611519 0.780 rs9611527 chr22:41644428 G/A cg03806693 chr22:41940476 POLR3H -0.67 -9.28 -0.46 2.32e-18 Neuroticism; CRC cis rs2243480 1.000 rs35391607 chr7:65360829 G/A cg18252515 chr7:66147081 NA -1.17 -13.57 -0.6 1.26e-33 Diabetic kidney disease; CRC cis rs3760982 1.000 rs60184524 chr19:44294215 A/G cg21496419 chr19:44306685 LYPD5 0.33 6.22 0.32 1.47e-9 Breast cancer (estrogen-receptor negative);Breast cancer; CRC cis rs7605378 1.000 rs10194076 chr2:200677663 T/C cg23649088 chr2:200775458 C2orf69 0.58 8.13 0.41 8.99e-15 Osteoporosis; CRC cis rs7833986 1.000 rs34516759 chr8:57097138 G/A cg23139584 chr8:56987506 RPS20;SNORD54 0.61 7.54 0.38 4.64e-13 Height; CRC trans rs6076960 0.629 rs6054008 chr20:6212370 C/T cg21095983 chr6:86352623 SYNCRIP 0.54 7.76 0.39 1.11e-13 Smooth-surface caries; CRC cis rs28386778 0.897 rs8079818 chr17:61824667 C/G cg11494091 chr17:61959527 GH2 0.63 10.75 0.51 2.66e-23 Prudent dietary pattern; CRC cis rs875971 0.638 rs801216 chr7:66011667 T/C cg25985355 chr7:65971099 NA 0.32 5.67 0.3 3.12e-8 Aortic root size; CRC cis rs6594499 0.872 rs10043631 chr5:110443228 C/T cg04022379 chr5:110408740 TSLP 0.48 7.34 0.38 1.64e-12 Allergic disease (asthma, hay fever or eczema); CRC cis rs72781680 0.611 rs72781696 chr2:24267014 C/T cg20701182 chr2:24300061 SF3B14 0.59 6.69 0.35 9.34e-11 Lymphocyte counts; CRC cis rs9549260 0.755 rs12585277 chr13:41224813 C/T cg21288729 chr13:41239152 FOXO1 0.49 7.63 0.39 2.54e-13 Red blood cell count; CRC cis rs8067545 0.641 rs203455 chr17:19821185 A/G cg04132472 chr17:19861366 AKAP10 0.43 6.83 0.35 4.01e-11 Schizophrenia; CRC cis rs9443645 0.901 rs1538233 chr6:79743735 G/T cg05283184 chr6:79620031 NA -0.6 -9.58 -0.47 2.46e-19 Intelligence (multi-trait analysis); CRC trans rs12517041 1.000 rs10068478 chr5:23297003 G/A ch.8.1293020R chr8:59333349 UBXN2B -0.55 -6.17 -0.32 2.05e-9 Calcium levels; CRC cis rs1348850 0.958 rs10930799 chr2:178459325 G/C cg22681709 chr2:178499509 PDE11A -0.32 -5.94 -0.31 7.11e-9 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs1215050 0.791 rs649866 chr4:98738826 T/C cg05340658 chr4:99064831 C4orf37 0.44 6.45 0.33 4.07e-10 Waist-to-hip ratio adjusted for body mass index; CRC cis rs6952808 0.929 rs12699483 chr7:1975624 C/G cg22963979 chr7:1858916 MAD1L1 -0.55 -7.76 -0.39 1.05e-13 Bipolar disorder and schizophrenia; CRC cis rs929596 0.517 rs3806592 chr2:234625936 C/T cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.56 -8.74 -0.43 1.19e-16 Total bilirubin levels in HIV-1 infection; CRC cis rs11997175 0.646 rs55898196 chr8:33765862 A/G ch.8.33884649F chr8:33765107 NA 0.48 6.79 0.35 5.37e-11 Body mass index; CRC cis rs523522 0.962 rs7136951 chr12:120941927 C/T cg12219531 chr12:120966889 COQ5 0.62 8.39 0.42 1.41e-15 High light scatter reticulocyte count; CRC cis rs4604732 0.631 rs75320597 chr1:247626751 T/G cg02104434 chr1:247694406 LOC148824;OR2C3 0.6 8.82 0.44 6.67e-17 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CRC cis rs11098499 0.754 rs2036860 chr4:120248934 A/G cg09307838 chr4:120376055 NA 0.62 9.64 0.47 1.54e-19 Corneal astigmatism; CRC trans rs7395662 1.000 rs55834832 chr11:48562583 T/G cg21153622 chr11:89784906 NA -0.44 -7.11 -0.36 7.07e-12 HDL cholesterol; CRC cis rs9393692 0.905 rs9379838 chr6:26277133 C/T cg05868516 chr6:26286170 HIST1H4H 0.38 5.62 0.3 4.02e-8 Educational attainment; CRC cis rs6964587 0.839 rs6952459 chr7:91435820 T/A cg17063962 chr7:91808500 NA 0.68 10.57 0.5 1.13e-22 Breast cancer; CRC trans rs875971 0.660 rs2191268 chr7:66110224 C/T cg01479122 chr15:32163262 NA -0.39 -6.36 -0.33 6.57e-10 Aortic root size; CRC cis rs7614311 0.681 rs73117036 chr3:63892725 G/C cg22134162 chr3:63841271 THOC7 -0.59 -5.97 -0.31 6.18e-9 Lung function (FVC);Lung function (FEV1); CRC cis rs919433 0.714 rs2333855 chr2:198200213 T/G cg20885578 chr2:198174922 NA -0.36 -5.82 -0.31 1.41e-8 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC cis rs11190604 1.000 rs7088827 chr10:102303865 C/G cg16342193 chr10:102329863 NA -0.35 -5.93 -0.31 7.54e-9 Palmitoleic acid (16:1n-7) levels; CRC cis rs9487051 0.714 rs9386797 chr6:109632520 C/A cg01475377 chr6:109611718 NA -0.38 -6.73 -0.35 7.55e-11 Reticulocyte fraction of red cells; CRC cis rs1005277 0.505 rs1208689 chr10:38097775 C/G cg25517755 chr10:38738941 LOC399744 -0.44 -6.44 -0.33 4.22e-10 Extrinsic epigenetic age acceleration; CRC cis rs9399135 0.967 rs4388304 chr6:135309597 T/A cg24558204 chr6:135376177 HBS1L 0.49 7.72 0.39 1.36e-13 Red blood cell count; CRC cis rs12545109 0.800 rs1440746 chr8:57415912 G/A cg09654669 chr8:57350985 NA -0.45 -7.28 -0.37 2.43e-12 Obesity-related traits; CRC cis rs57221529 0.563 rs4957057 chr5:569230 C/G cg16447950 chr5:562315 NA -0.86 -13.08 -0.58 9.48e-32 Lung disease severity in cystic fibrosis; CRC cis rs12476592 0.602 rs1867849 chr2:63726932 C/T cg10828910 chr2:63850056 LOC388955 0.49 6.08 0.32 3.33e-9 Childhood ear infection; CRC cis rs9910055 0.529 rs228749 chr17:42174570 A/G cg19774624 chr17:42201019 HDAC5 0.44 5.73 0.3 2.29e-8 Total body bone mineral density; CRC cis rs7799006 0.606 rs34417375 chr7:2315105 C/T cg08027265 chr7:2291960 NA -0.45 -7.42 -0.38 9.94e-13 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs9463078 0.691 rs4398713 chr6:45003928 C/T cg25276700 chr6:44698697 NA 0.25 5.95 0.31 6.99e-9 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; CRC cis rs12887734 0.546 rs12885509 chr14:104273325 T/C cg01849466 chr14:104193079 ZFYVE21 -0.41 -6.33 -0.33 7.88e-10 Schizophrenia;Autism spectrum disorder or schizophrenia; CRC cis rs28374715 0.532 rs316604 chr15:41775221 C/T cg18705301 chr15:41695430 NDUFAF1 -1.12 -20.21 -0.74 1.25e-59 Ulcerative colitis; CRC cis rs6500602 0.701 rs1362626 chr16:4549226 C/G cg14951292 chr16:4525986 HMOX2;NMRAL1 0.59 8.8 0.44 7.75e-17 Schizophrenia; CRC trans rs9395066 0.545 rs4714828 chr6:44846008 A/G cg04786201 chr1:17185605 NA 0.3 6.38 0.33 6.01e-10 Height; CRC cis rs9925964 0.967 rs4889620 chr16:31131174 G/A cg10396673 chr16:31104726 VKORC1 0.34 5.62 0.3 3.99e-8 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs9640161 0.742 rs11983355 chr7:150016697 A/C cg13722127 chr7:150037890 RARRES2 0.48 7.48 0.38 6.84e-13 Blood protein levels;Circulating chemerin levels; CRC cis rs9486719 0.948 rs11153059 chr6:97014537 T/A cg06623918 chr6:96969491 KIAA0776 -0.82 -9.53 -0.47 3.58e-19 Migraine;Coronary artery disease; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg19824897 chr13:79979916 RBM26 0.45 6.4 0.33 5.48e-10 Response to antipsychotic treatment; CRC trans rs4586057 0.767 rs2901026 chr10:92615660 A/C cg26894278 chr13:21016241 CRYL1 0.38 6.29 0.33 9.83e-10 Economic and political preferences (time); CRC cis rs9787249 0.957 rs1046988 chr1:40219065 A/G cg24920358 chr1:40204285 PPIE -0.58 -8.96 -0.44 2.42e-17 Blood protein levels; CRC cis rs10992471 0.528 rs10117627 chr9:95203953 G/A cg14631576 chr9:95140430 CENPP -0.33 -6.09 -0.32 3.13e-9 Visceral adipose tissue/subcutaneous adipose tissue ratio; CRC cis rs9469578 0.892 rs6929527 chr6:33707976 G/T cg18708504 chr6:33715942 IP6K3 0.65 7.42 0.38 9.77e-13 Phosphorus levels; CRC cis rs4654899 0.897 rs3736880 chr1:21097727 G/A cg02927042 chr1:21476669 EIF4G3 -0.41 -6.45 -0.34 4e-10 Superior frontal gyrus grey matter volume; CRC cis rs2814982 0.605 rs75152896 chr6:34477793 G/A cg14254433 chr6:34482411 PACSIN1 -0.82 -8.7 -0.43 1.62e-16 Cholesterol, total;Total cholesterol levels; CRC cis rs4733781 0.509 rs6470811 chr8:131338933 G/T cg21674704 chr8:131455249 NA 0.35 5.75 0.3 2.05e-8 Tuberculosis; CRC cis rs9733 0.744 rs12125650 chr1:150760174 A/G cg18016565 chr1:150552671 MCL1 -0.39 -5.66 -0.3 3.32e-8 Tonsillectomy; CRC cis rs2760061 0.626 rs2527614 chr1:228126470 A/G cg02753203 chr1:228287806 NA -0.64 -9.54 -0.47 3.31e-19 Diastolic blood pressure; CRC trans rs7580658 0.614 rs7585198 chr2:127962635 C/T cg19238398 chr5:138775248 DNAJC18 -0.41 -6.27 -0.33 1.11e-9 Protein C levels; CRC cis rs1046896 0.586 rs9897951 chr17:80810662 T/C cg17346650 chr17:80929145 B3GNTL1 0.48 7.14 0.37 5.94e-12 Glycated hemoglobin levels; CRC cis rs9611565 0.579 rs73178621 chr22:41921665 A/G cg03806693 chr22:41940476 POLR3H -1.14 -14.84 -0.63 1.76e-38 Vitiligo; CRC cis rs17401966 0.540 rs11121566 chr1:10472848 C/G cg19773385 chr1:10388646 KIF1B -0.49 -7.71 -0.39 1.47e-13 Hepatocellular carcinoma; CRC cis rs2985684 0.779 rs12160 chr14:50091932 T/A cg10008539 chr14:50087325 RPL36AL;MGAT2 -0.45 -6.1 -0.32 3.01e-9 Carotid intima media thickness; CRC cis rs4595586 0.546 rs11609849 chr12:39258090 C/G cg26384229 chr12:38710491 ALG10B 0.54 6.64 0.34 1.28e-10 Morning vs. evening chronotype; CRC trans rs2795502 1.000 rs2744090 chr10:43339614 G/C cg06791473 chr12:49259579 RND1 0.61 6.03 0.32 4.5e-9 Blood protein levels; CRC cis rs6840360 0.571 rs11099823 chr4:152510565 T/G cg09659197 chr4:152720779 NA 0.3 5.62 0.3 4.07e-8 Intelligence (multi-trait analysis); CRC cis rs853679 0.517 rs35193936 chr6:28076270 A/G cg25164649 chr6:28176230 NA 0.75 9.32 0.46 1.72e-18 Depression; CRC cis rs1799949 1.000 rs35070007 chr17:41316747 C/G cg07153921 chr17:41440717 NA 0.38 5.77 0.3 1.84e-8 Menopause (age at onset); CRC trans rs7800418 0.723 rs1029558 chr7:26588391 C/T cg14387656 chr2:233470847 EFHD1 -0.46 -6.32 -0.33 8.33e-10 Cognitive function; CRC cis rs972578 0.715 rs5758969 chr22:43228969 A/C cg01576275 chr22:43409880 NA -0.35 -5.65 -0.3 3.42e-8 Mean platelet volume; CRC cis rs8014671 0.532 rs12893988 chr14:70922142 C/A cg25576086 chr14:70833871 SYNJ2BP -0.35 -5.81 -0.3 1.51e-8 Prostate cancer; CRC cis rs155076 1.000 rs9509638 chr13:21860193 G/A cg21970626 chr13:21893289 NA 0.43 5.68 0.3 2.9e-8 White matter hyperintensity burden; CRC cis rs2836974 0.965 rs7354783 chr21:40652992 G/A cg06238570 chr21:40685208 BRWD1 0.79 10.86 0.51 1.11e-23 Cognitive function; CRC cis rs7618915 0.547 rs4687636 chr3:52633929 G/A cg18099408 chr3:52552593 STAB1 -0.45 -7.3 -0.37 2.19e-12 Bipolar disorder; CRC cis rs28386778 0.897 rs3785572 chr17:61829989 C/T cg25654072 chr17:61904446 PSMC5;FTSJ3 0.71 11.11 0.52 1.42e-24 Prudent dietary pattern; CRC cis rs4713118 0.523 rs2179096 chr6:27665920 C/T cg15786705 chr6:28176104 NA 0.47 6.86 0.35 3.43e-11 Parkinson's disease; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg26605996 chr7:102389191 FAM185A 0.41 6.81 0.35 4.56e-11 Liver disease severity in Alagille syndrome; CRC cis rs28386778 0.897 rs2727330 chr17:61925498 A/G cg25654072 chr17:61904446 PSMC5;FTSJ3 -0.7 -11.09 -0.52 1.71e-24 Prudent dietary pattern; CRC cis rs1707322 0.686 rs3014235 chr1:46091512 A/G cg06784218 chr1:46089804 CCDC17 -0.66 -12.02 -0.55 7.8e-28 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs2979489 0.891 rs17552243 chr8:30362627 T/C cg26383811 chr8:30366931 RBPMS -0.7 -10.1 -0.49 4.69e-21 Mean corpuscular hemoglobin;Plateletcrit;Neutrophil count;Granulocyte count;Sum basophil neutrophil counts;Mean corpuscular volume;Myeloid white cell count;Sum neutrophil eosinophil counts; CRC cis rs6502050 0.769 rs11658272 chr17:80084596 C/T cg13198984 chr17:80129470 CCDC57 -0.48 -8.56 -0.43 4.49e-16 Life satisfaction; CRC cis rs2836974 0.563 rs997147 chr21:40695325 A/G cg11644478 chr21:40555479 PSMG1 -0.66 -10.56 -0.5 1.21e-22 Cognitive function; CRC cis rs10791323 0.546 rs55801927 chr11:133713094 A/C cg15485101 chr11:133734466 NA 0.43 7.45 0.38 8.2e-13 Childhood ear infection; CRC cis rs1322512 1.000 rs2800626 chr6:153006340 T/A cg03415253 chr6:152958462 SYNE1 0.4 6.04 0.32 4.18e-9 Tonometry; CRC cis rs9916302 0.861 rs12150493 chr17:37586154 T/C cg03013999 chr17:37608204 MED1 0.47 7.31 0.37 2e-12 Glomerular filtration rate (creatinine); CRC cis rs1552244 0.572 rs6785976 chr3:10168647 A/G cg16606324 chr3:10149918 C3orf24 0.66 7.76 0.39 1.06e-13 Alzheimer's disease; CRC cis rs10504229 0.683 rs6998040 chr8:58110155 G/T cg22535103 chr8:58192502 C8orf71 0.73 9.69 0.47 1.05e-19 Developmental language disorder (linguistic errors); CRC cis rs780094 0.500 rs13022873 chr2:27815510 A/C cg27432699 chr2:27873401 GPN1 0.49 6.35 0.33 7.06e-10 Calcium levels;Fasting blood insulin;Metabolic traits;Triglyceride levels;Fasting plasma glucose;Urate levels in overweight individuals;Urate levels in obese individuals;Uric acid levels;Height;Age-related diseases, mortality and associated endophenotypes;Renal underexcretion gout;Fasting blood glucose (BMI interaction);Urate levels;Gondoic acid (20:1n-9) levels;Fasting blood insulin (BMI interaction);Triglycerides;Plasma omega-3 polyunsaturated fatty acid levels (docosapentaenoic acid);Type 2 diabetes;Nonalcoholic fatty liver disease;Hypertriglyceridemia;C-reactive protein;Age-related disease endophenotypes;LDL cholesterol;Metabolic syndrome;Crohn's disease;Alcohol consumption (drinks per week);Homeostasis model assessment of insulin resistance;Alcohol consumption;Red blood cell count;Fasting blood glucose; CRC cis rs666930 0.519 rs532303 chr1:120265444 A/G cg19096424 chr1:120255104 PHGDH 0.57 8.24 0.41 4.16e-15 Breast cancer; CRC cis rs4563143 0.647 rs117946634 chr19:29256822 G/T cg03161606 chr19:29218774 NA 0.53 6.62 0.34 1.49e-10 Methadone dose in opioid dependence; CRC cis rs10504073 0.584 rs56074306 chr8:49940282 C/T cg00325661 chr8:49890786 NA 0.6 10.84 0.51 1.25e-23 Blood metabolite ratios; CRC cis rs7086627 0.515 rs7088877 chr10:82208860 C/G cg09626299 chr10:82213104 TSPAN14 -0.37 -6.23 -0.33 1.39e-9 Post bronchodilator FEV1; CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg27233566 chr3:49894142 TRAIP 0.38 6.06 0.32 3.82e-9 Obesity-related traits; CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg20645649 chr9:127624485 RPL35 -0.52 -6.35 -0.33 7.19e-10 Diisocyanate-induced asthma; CRC cis rs10504229 0.683 rs6980540 chr8:58127022 A/G cg22535103 chr8:58192502 C8orf71 -0.69 -9.23 -0.45 3.37e-18 Developmental language disorder (linguistic errors); CRC cis rs10905065 0.833 rs6602259 chr10:5844628 C/T cg11519256 chr10:5708881 ASB13 0.51 7.64 0.39 2.34e-13 Menopause (age at onset); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg22403971 chr6:119671423 MAN1A1 0.4 6.17 0.32 2.03e-9 Intelligence (multi-trait analysis); CRC cis rs11971779 0.618 rs9640925 chr7:139085288 G/A cg23387468 chr7:139079360 LUC7L2 0.41 7.04 0.36 1.14e-11 Diisocyanate-induced asthma; CRC cis rs1552244 1.000 rs9845756 chr3:10067548 G/C cg08888203 chr3:10149979 C3orf24 0.69 9.65 0.47 1.46e-19 Alzheimer's disease; CRC trans rs916888 0.773 rs1378358 chr17:44787312 C/T cg10053473 chr17:62856997 LRRC37A3 -0.8 -8.61 -0.43 3.11e-16 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg03969138 chr6:7390163 RIOK1;CAGE1 0.49 6.3 0.33 9.81e-10 Thyroid stimulating hormone; CRC cis rs11214589 0.747 rs11214577 chr11:113204266 A/G cg14159747 chr11:113255604 NA -0.5 -9.18 -0.45 5.05e-18 Neuroticism; CRC trans rs1814175 0.647 rs1404157 chr11:49917301 G/C cg03929089 chr4:120376271 NA -0.76 -12.48 -0.57 1.56e-29 Height; CRC cis rs9399137 0.507 rs7748708 chr6:135275142 G/A cg22676075 chr6:135203613 NA 0.62 9.3 0.46 1.99e-18 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; CRC cis rs7824557 0.564 rs6601584 chr8:11232343 C/G cg08071915 chr8:12219732 FAM66A 0.35 6.47 0.34 3.45e-10 Retinal vascular caliber; CRC cis rs9914988 0.943 rs2043031 chr17:27085564 A/G cg16670446 chr17:27188758 MIR451;MIR144 0.55 8.59 0.43 3.66e-16 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs9311474 0.607 rs4234633 chr3:52557038 C/T cg18404041 chr3:52824283 ITIH1 -0.35 -7.03 -0.36 1.21e-11 Electroencephalogram traits; CRC cis rs501916 0.634 rs61333299 chr15:48066806 G/A cg16110827 chr15:48056943 SEMA6D -0.44 -6.43 -0.33 4.58e-10 Inflammatory bowel disease;Ulcerative colitis; CRC trans rs1814175 0.817 rs12277258 chr11:49940216 T/C cg11707556 chr5:10655725 ANKRD33B -0.44 -8.31 -0.42 2.52e-15 Height; CRC cis rs736801 0.780 rs2188962 chr5:131770805 C/T cg00255919 chr5:131827918 IRF1 -0.35 -5.95 -0.31 6.84e-9 Breast cancer;Mosquito bite size; CRC cis rs6831352 0.918 rs29001214 chr4:100051733 A/G cg13256891 chr4:100009986 ADH5 -0.65 -8.86 -0.44 5.21e-17 Alcohol dependence; CRC cis rs2034088 0.833 rs9748016 chr17:410451 G/T cg13332499 chr17:408570 NA 0.38 8.53 0.43 5.38e-16 Hip circumference adjusted for BMI; CRC cis rs7086627 0.515 rs10887896 chr10:82210144 A/C cg00277334 chr10:82204260 NA -0.84 -16.84 -0.68 2.56e-46 Post bronchodilator FEV1; CRC cis rs5769765 0.779 rs12170530 chr22:50318422 T/G cg02269571 chr22:50332266 NA -0.62 -7.71 -0.39 1.5e-13 Schizophrenia; CRC cis rs7786808 0.707 rs11770299 chr7:158228822 G/A cg17401720 chr7:158221031 PTPRN2 0.47 7.76 0.39 1.09e-13 Obesity-related traits; CRC cis rs6089584 0.927 rs1886007 chr20:60581049 G/A cg12751644 chr20:60527061 NA -0.34 -5.7 -0.3 2.62e-8 Body mass index; CRC cis rs7259376 0.846 rs4024624 chr19:22568264 C/T cg02657401 chr19:22469223 NA -0.32 -7.06 -0.36 1.02e-11 Menopause (age at onset); CRC cis rs243505 0.660 rs3807450 chr7:148522269 C/A cg09806900 chr7:148480153 CUL1 0.53 6.69 0.35 9.4e-11 Inflammatory bowel disease;Crohn's disease; CRC cis rs1799949 0.965 rs8176323 chr17:41195711 G/C cg19454999 chr17:41278357 BRCA1;NBR2 0.54 8.52 0.43 5.78e-16 Menopause (age at onset); CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg27660920 chr20:37554817 FAM83D -0.43 -6.46 -0.34 3.69e-10 Myopia (pathological); CRC cis rs447 0.806 rs12707615 chr7:83745349 T/C cg22846510 chr7:83753280 SEMA3A -0.41 -5.7 -0.3 2.65e-8 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs1005277 0.579 rs11011461 chr10:38431427 G/A cg17219203 chr10:38645113 HSD17B7P2 -0.4 -5.66 -0.3 3.27e-8 Extrinsic epigenetic age acceleration; CRC cis rs66569888 0.633 rs11124085 chr2:106758629 A/G cg16099169 chr2:106886729 NA -0.4 -6.04 -0.32 4.25e-9 Facial morphology (factor 23); CRC cis rs2204008 0.837 rs2387317 chr12:38235319 T/C cg13010199 chr12:38710504 ALG10B 0.45 5.82 0.31 1.39e-8 Bladder cancer; CRC cis rs2204008 0.558 rs66545149 chr12:38204694 A/G cg26384229 chr12:38710491 ALG10B 0.64 8.19 0.41 5.89e-15 Bladder cancer; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg00050312 chr17:64299065 PRKCA 0.48 6.85 0.35 3.66e-11 Response to antipsychotic treatment; CRC cis rs71403859 0.502 rs36122765 chr16:71504183 G/C cg08717414 chr16:71523259 ZNF19 -1.0 -10.74 -0.51 2.83e-23 Post bronchodilator FEV1; CRC cis rs17270561 1.000 rs79867288 chr6:25828416 A/G cg16482183 chr6:26056742 HIST1H1C 0.93 10.45 0.5 2.97e-22 Iron status biomarkers; CRC cis rs2153535 0.580 rs6597334 chr6:8504779 C/T cg21535247 chr6:8435926 SLC35B3 0.47 7.23 0.37 3.47e-12 Motion sickness; CRC trans rs62103177 0.564 rs1715230 chr18:77848002 C/T cg05926928 chr17:57297772 GDPD1 0.6 6.6 0.34 1.68e-10 Opioid sensitivity; CRC trans rs2243480 0.908 rs2460431 chr7:65622846 A/G cg10756647 chr7:56101905 PSPH -0.76 -7.89 -0.4 4.47e-14 Diabetic kidney disease; CRC cis rs1552244 0.572 rs68121641 chr3:10165845 T/A cg13047869 chr3:10149882 C3orf24 0.54 6.49 0.34 3.1e-10 Alzheimer's disease; CRC cis rs67311347 0.911 rs9849224 chr3:40392562 T/C cg09455208 chr3:40491958 NA 0.43 9.02 0.45 1.59e-17 Renal cell carcinoma; CRC cis rs12200560 0.505 rs211165 chr6:97068520 A/T cg06623918 chr6:96969491 KIAA0776 0.47 6.79 0.35 5.13e-11 Coronary heart disease; CRC cis rs9303401 0.538 rs2240258 chr17:56458183 C/A cg02118635 chr17:56770003 RAD51C;TEX14 0.72 8.4 0.42 1.37e-15 Cognitive test performance; CRC cis rs9388451 0.869 rs7764016 chr6:126070789 T/G cg05901451 chr6:126070800 HEY2 -0.69 -12.2 -0.56 1.74e-28 Brugada syndrome; CRC cis rs1552244 1.000 rs7637888 chr3:10080722 T/C cg02579736 chr3:10068473 FANCD2;CIDECP 1.05 14.06 0.61 1.71e-35 Alzheimer's disease; CRC cis rs9612 0.950 rs7256472 chr19:44246970 C/T cg08581076 chr19:44259116 C19orf61 0.52 6.58 0.34 1.8e-10 Exhaled nitric oxide output; CRC cis rs9916302 0.706 rs9893735 chr17:37469858 A/C cg00129232 chr17:37814104 STARD3 0.57 7.22 0.37 3.66e-12 Glomerular filtration rate (creatinine); CRC cis rs6120849 0.754 rs3746435 chr20:33587198 G/C cg24642439 chr20:33292090 TP53INP2 0.44 5.68 0.3 3.04e-8 Protein C levels; CRC cis rs1008375 0.966 rs2302393 chr4:17654341 G/A cg16339924 chr4:17578868 LAP3 0.6 8.15 0.41 7.76e-15 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs12824058 0.737 rs11060829 chr12:130814996 G/T cg24838063 chr12:130822603 PIWIL1 0.58 9.81 0.48 4.38e-20 Menopause (age at onset); CRC cis rs10751667 1.000 rs7395632 chr11:958789 C/T cg23136738 chr11:925521 AP2A2 0.47 7.57 0.39 3.69e-13 Alzheimer's disease (late onset); CRC cis rs6694672 0.614 rs1556763 chr1:197152149 A/C cg13682187 chr1:196946512 CFHR5 0.44 7.09 0.36 8.2e-12 Asthma; CRC cis rs8017423 0.647 rs11626821 chr14:90824945 A/G cg14092571 chr14:90743983 NA 0.38 5.91 0.31 8.37e-9 Mortality in heart failure; CRC cis rs478304 0.654 rs10896035 chr11:65461160 G/A cg27068330 chr11:65405492 SIPA1 -0.66 -9.8 -0.48 4.53e-20 Acne (severe); CRC cis rs9549260 0.727 rs4603422 chr13:41148353 T/C cg21288729 chr13:41239152 FOXO1 0.4 6.09 0.32 3.15e-9 Red blood cell count; CRC cis rs9916302 0.847 rs7218670 chr17:37500424 G/A cg00129232 chr17:37814104 STARD3 0.54 7.97 0.4 2.68e-14 Glomerular filtration rate (creatinine); CRC cis rs1046896 0.562 rs2380172 chr17:80887719 C/A cg16060761 chr17:80687452 NA -0.48 -6.26 -0.33 1.18e-9 Glycated hemoglobin levels; CRC cis rs67478160 0.572 rs8016014 chr14:104293798 G/C cg08213375 chr14:104286397 PPP1R13B 0.66 13.39 0.59 6.24e-33 Schizophrenia; CRC cis rs9309473 0.607 rs12478346 chr2:73584360 C/T cg20560298 chr2:73613845 ALMS1 -0.51 -6.91 -0.36 2.49e-11 Metabolite levels; CRC cis rs2160860 0.965 rs10085935 chr8:39806267 C/T cg11363097 chr8:39792086 IDO2 -0.39 -6.51 -0.34 2.75e-10 Blood metabolite levels; CRC trans rs208520 1.000 rs12189683 chr6:66977716 A/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.87 -10.77 -0.51 2.35e-23 Exhaled nitric oxide output; CRC cis rs1801251 0.964 rs10933411 chr2:233706847 A/G cg25237894 chr2:233734115 C2orf82 -0.54 -8.79 -0.44 8.63e-17 Coronary artery disease; CRC cis rs7247513 0.964 rs12979795 chr19:12717847 C/T cg01871581 chr19:12707946 ZNF490 0.77 13.09 0.59 8.25e-32 Bipolar disorder; CRC cis rs7927771 1.000 rs7927771 chr11:47781306 A/G cg18512352 chr11:47633146 NA -0.49 -9.48 -0.46 5.08e-19 Subjective well-being; CRC cis rs9611565 0.659 rs73178626 chr22:41928371 T/G cg06634786 chr22:41940651 POLR3H -0.68 -7.99 -0.4 2.33e-14 Vitiligo; CRC cis rs6951245 1.000 rs78896566 chr7:1080182 C/G cg04025307 chr7:1156635 C7orf50 0.64 6.76 0.35 6.29e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs514406 0.893 rs522287 chr1:53365493 C/T cg25767906 chr1:53392781 SCP2 -0.49 -7.85 -0.4 6e-14 Monocyte count; CRC cis rs7937682 0.632 rs7128862 chr11:111755435 C/T cg09085632 chr11:111637200 PPP2R1B 0.95 15.06 0.64 2.3e-39 Primary sclerosing cholangitis; CRC cis rs2976388 0.507 rs2572874 chr8:143837219 C/T cg04969067 chr8:143858791 LYNX1 0.58 10.06 0.48 6.39e-21 Urinary tract infection frequency; CRC cis rs1552244 1.000 rs3826 chr3:10141065 T/G cg10729496 chr3:10149963 C3orf24 0.49 6.78 0.35 5.57e-11 Alzheimer's disease; CRC cis rs6912958 0.559 rs2985039 chr6:88041757 A/G cg08069147 chr6:88032118 GJB7;C6orf162 0.75 12.12 0.56 3.32e-28 Monocyte percentage of white cells; CRC cis rs5771242 0.769 rs4838865 chr22:50664612 A/G cg16473166 chr22:50639996 SELO 0.52 5.97 0.31 6.09e-9 Lung function (forced expiratory flow during mid-portion (25% and 75%) of forced vital capacity); CRC cis rs7927771 0.864 rs755554 chr11:47432034 G/C cg20307385 chr11:47447363 PSMC3 0.61 8.96 0.44 2.45e-17 Subjective well-being; CRC cis rs3812565 0.530 rs10781538 chr9:139320929 C/G cg14169450 chr9:139327907 INPP5E -0.36 -5.89 -0.31 9.72e-9 Granulocyte percentage of myeloid white cells; CRC trans rs1814175 0.817 rs10769598 chr11:49669326 C/G cg15704280 chr7:45808275 SEPT13 -0.97 -18.9 -0.72 1.77e-54 Height; CRC cis rs769267 0.965 rs2315025 chr19:19426609 C/T cg20644253 chr19:19431407 KIAA0892;SF4 0.42 5.9 0.31 8.91e-9 Tonsillectomy; CRC cis rs832540 0.669 rs832538 chr5:56200016 C/T cg12311346 chr5:56204834 C5orf35 -0.56 -8.32 -0.42 2.37e-15 Coronary artery disease; CRC cis rs12421382 0.507 rs10890995 chr11:109327622 A/G cg27471124 chr11:109292789 C11orf87 -0.31 -6.05 -0.32 4.03e-9 Schizophrenia; CRC cis rs12497850 0.931 rs6446196 chr3:49004723 A/G cg20833759 chr3:49053208 WDR6;DALRD3 0.54 9.33 0.46 1.58e-18 Parkinson's disease; CRC cis rs427941 0.632 rs201471 chr7:101744145 T/G cg06246474 chr7:101738831 CUX1 0.43 6.68 0.35 1.01e-10 Plasma omega-3 polyunsaturated fatty acid level (eicosapentaenoic acid); CRC cis rs9807989 0.507 rs2058659 chr2:103054556 A/G cg03938978 chr2:103052716 IL18RAP -0.57 -10.06 -0.48 6.29e-21 Asthma; CRC trans rs10242455 0.571 rs7805661 chr7:99171522 A/C cg09045935 chr12:6379348 NA 1.06 8.4 0.42 1.36e-15 Blood metabolite levels; CRC trans rs2303319 0.504 rs58622044 chr2:162596287 A/G cg23247704 chr1:116518985 SLC22A15 -0.73 -6.21 -0.32 1.57e-9 Cognitive function; CRC cis rs728616 0.867 rs7906286 chr10:81834035 T/C cg05935833 chr10:81318306 SFTPA2 -0.47 -5.93 -0.31 7.48e-9 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs3824867 0.920 rs3740684 chr11:47468820 C/T cg05585544 chr11:47624801 NA -0.41 -6.35 -0.33 7.09e-10 Mean corpuscular hemoglobin; CRC trans rs2727020 0.521 rs10839299 chr11:49573981 C/T cg11707556 chr5:10655725 ANKRD33B -0.48 -7.69 -0.39 1.71e-13 Coronary artery disease; CRC cis rs9309711 0.689 rs4535075 chr2:3481716 T/C cg08493051 chr2:3487164 NA -0.39 -5.71 -0.3 2.53e-8 Neurofibrillary tangles; CRC cis rs919433 0.963 rs4850787 chr2:198181750 G/A cg03934865 chr2:198174659 NA -0.42 -6.95 -0.36 1.93e-11 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC cis rs72781680 0.821 rs72796325 chr2:24134537 G/A cg08917208 chr2:24149416 ATAD2B 0.55 6.71 0.35 8.52e-11 Lymphocyte counts; CRC cis rs1957429 0.614 rs73279812 chr14:65348012 G/A cg23373153 chr14:65346875 NA -0.65 -5.89 -0.31 9.49e-9 Pediatric areal bone mineral density (radius); CRC cis rs68170813 0.523 rs75999022 chr7:107017135 C/T cg02696742 chr7:106810147 HBP1 -0.56 -5.97 -0.31 6.13e-9 Coronary artery disease; CRC cis rs909002 0.745 rs4949458 chr1:32142332 G/T cg13919466 chr1:32135498 COL16A1 0.29 5.71 0.3 2.55e-8 Intelligence (multi-trait analysis); CRC cis rs9322193 0.923 rs9322197 chr6:149943713 C/A cg13206674 chr6:150067644 NUP43 0.58 8.43 0.42 1.11e-15 Lung cancer; CRC cis rs853679 0.517 rs9380052 chr6:28064623 A/G cg15786705 chr6:28176104 NA 0.77 9.73 0.47 8e-20 Depression; CRC cis rs7524258 0.903 rs4908450 chr1:7292756 T/C cg07173049 chr1:7289937 CAMTA1 0.67 10.67 0.51 4.99e-23 Tourette's syndrome or obsessive-compulsive disorder; CRC trans rs13046373 0.905 rs4816372 chr21:32077414 A/T cg03930837 chr17:41132080 RUNDC1;AARSD1 -0.41 -6.1 -0.32 3.03e-9 HDL cholesterol; CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg25199208 chr2:109402912 CCDC138 -0.49 -6.2 -0.32 1.71e-9 Diisocyanate-induced asthma; CRC cis rs798554 0.610 rs1182173 chr7:2878016 C/G cg13628971 chr7:2884303 GNA12 0.4 6.27 0.33 1.13e-9 Height; CRC cis rs9435341 0.860 rs12406721 chr1:107563243 G/T cg14828511 chr1:107599125 PRMT6 0.48 6.53 0.34 2.49e-10 Facial morphology (factor 21, depth of nasal alae); CRC cis rs116095464 0.558 rs10076655 chr5:239464 G/C cg22496380 chr5:211416 CCDC127 -0.91 -10.38 -0.5 5.2e-22 Breast cancer; CRC cis rs10540 0.730 rs61876338 chr11:493730 A/G cg03576123 chr11:487126 PTDSS2 -1.04 -10.79 -0.51 1.91e-23 Body mass index; CRC cis rs9322193 0.926 rs9689036 chr6:150101699 T/C cg04369109 chr6:150039330 LATS1 -0.43 -6.01 -0.31 4.85e-9 Lung cancer; CRC cis rs9487051 0.872 rs9487034 chr6:109605899 A/G cg21918786 chr6:109611834 NA -0.44 -8.0 -0.4 2.1e-14 Reticulocyte fraction of red cells; CRC trans rs6015450 1.000 rs75575888 chr20:57755060 A/G cg22122715 chr13:96086023 CLDN10 -0.57 -6.2 -0.32 1.69e-9 Diastolic blood pressure;Systolic blood pressure;Hypertension;Blood pressure; CRC cis rs11212617 1.000 rs7108522 chr11:108281004 A/G cg12106634 chr11:108092400 ATM;NPAT 0.44 6.66 0.34 1.13e-10 Response to metformin in type 2 diabetes (glycemic); CRC cis rs9902453 0.689 rs7216948 chr17:28203173 G/C cg26525008 chr17:28256777 EFCAB5;SSH2 0.69 11.2 0.53 6.98e-25 Coffee consumption (cups per day); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg06807126 chr1:46016862 AKR1A1 0.54 7.95 0.4 3.03e-14 Response to antipsychotic treatment; CRC cis rs2404602 0.692 rs12911902 chr15:77053575 T/C cg22467129 chr15:76604101 ETFA -0.4 -6.59 -0.34 1.78e-10 Blood metabolite levels; CRC cis rs853679 0.517 rs4711164 chr6:28115156 C/T cg15845792 chr6:28175446 NA 1.04 13.89 0.61 7.67e-35 Depression; CRC cis rs644799 0.526 rs568120 chr11:95578734 C/T cg03916912 chr11:95522834 CEP57;FAM76B 0.7 11.55 0.54 3.77e-26 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs10131894 0.611 rs175000 chr14:75436367 T/C cg03030879 chr14:75389066 RPS6KL1 0.39 5.94 0.31 7.44e-9 Coronary artery disease; CRC cis rs6032067 0.777 rs56063128 chr20:43783210 G/A cg10761708 chr20:43804764 PI3 0.47 5.62 0.3 4.05e-8 Blood protein levels; CRC cis rs6500602 0.627 rs709632 chr16:4587811 C/G cg14951292 chr16:4525986 HMOX2;NMRAL1 -0.61 -8.89 -0.44 4.06e-17 Schizophrenia; CRC cis rs155076 1.000 rs261407 chr13:21855213 C/A cg25811766 chr13:21894605 NA -0.59 -6.16 -0.32 2.17e-9 White matter hyperintensity burden; CRC trans rs2727020 0.704 rs4144700 chr11:49370834 C/A cg15704280 chr7:45808275 SEPT13 -0.89 -16.29 -0.67 3.52e-44 Coronary artery disease; CRC cis rs7705042 0.865 rs12653866 chr5:141489921 C/T cg07392085 chr5:141489673 NDFIP1 0.46 7.25 0.37 2.98e-12 Asthma; CRC cis rs13118159 0.509 rs4974554 chr4:1356967 A/C cg05025164 chr4:1340916 KIAA1530 0.6 8.5 0.42 6.55e-16 Longevity; CRC cis rs3026101 0.671 rs56300366 chr17:5297839 T/G cg25236894 chr17:5323110 RPAIN;NUP88 0.41 6.62 0.34 1.43e-10 Body mass index; CRC cis rs7216064 0.636 rs4638 chr17:66039350 A/G cg12091567 chr17:66097778 LOC651250 0.92 13.95 0.61 4.4e-35 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CRC cis rs9326248 0.539 rs7120565 chr11:117042949 T/C cg01368799 chr11:117014884 PAFAH1B2 0.57 9.36 0.46 1.34e-18 Blood protein levels; CRC cis rs9549367 0.789 rs9549701 chr13:113881752 G/C cg00898013 chr13:113819073 PROZ -0.46 -6.76 -0.35 6.31e-11 Platelet distribution width; CRC cis rs10504229 0.554 rs17802082 chr8:58095867 C/T cg24829409 chr8:58192753 C8orf71 -0.51 -6.93 -0.36 2.2e-11 Developmental language disorder (linguistic errors); CRC cis rs10489525 1.000 rs10489525 chr1:115263685 A/G cg12756093 chr1:115239321 AMPD1 0.54 7.28 0.37 2.54e-12 Autism; CRC cis rs1448094 0.511 rs17345975 chr12:86202318 T/A cg02569458 chr12:86230093 RASSF9 0.45 7.73 0.39 1.35e-13 Major depressive disorder; CRC cis rs3008870 0.755 rs1024229 chr1:67512903 G/T cg08660285 chr1:67390436 MIER1;WDR78 0.6 8.51 0.42 6.09e-16 Lymphocyte percentage of white cells; CRC cis rs354033 0.837 rs4727075 chr7:149187738 G/T cg24335155 chr7:149193227 ZNF746 0.42 6.51 0.34 2.84e-10 Multiple sclerosis; CRC cis rs4588572 0.643 rs7701154 chr5:77716621 G/A cg11446398 chr5:77624930 NA 0.46 6.26 0.33 1.21e-9 Triglycerides; CRC cis rs4964805 0.802 rs11111778 chr12:104185431 G/A cg02344784 chr12:104178138 NT5DC3 0.53 7.76 0.39 1.05e-13 Attention deficit hyperactivity disorder; CRC cis rs1387259 0.899 rs7307566 chr12:48604682 A/G cg21466736 chr12:48725269 NA -0.52 -7.98 -0.4 2.42e-14 Obstructive sleep apnea trait (apnea hypopnea index); CRC cis rs73206853 0.841 rs57821814 chr12:110829254 A/C cg12870014 chr12:110450643 ANKRD13A 0.82 8.81 0.44 7.43e-17 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC cis rs1799949 0.965 rs11658499 chr17:41334749 C/T cg01879757 chr17:41196368 BRCA1 -0.41 -6.16 -0.32 2.16e-9 Menopause (age at onset); CRC cis rs7618915 0.547 rs13065019 chr3:52685244 T/C cg07507251 chr3:52567010 NT5DC2 0.42 6.07 0.32 3.47e-9 Bipolar disorder; CRC cis rs801193 0.569 rs2707847 chr7:66202871 C/G cg00343986 chr7:65444356 GUSB 0.44 6.15 0.32 2.21e-9 Aortic root size; CRC cis rs9368481 0.761 rs6918835 chr6:27017827 T/G cg12292205 chr6:26970375 C6orf41 -0.63 -9.62 -0.47 1.78e-19 Autism spectrum disorder or schizophrenia; CRC cis rs9858542 0.953 rs9814873 chr3:49454112 A/G cg03060546 chr3:49711283 APEH -0.46 -6.51 -0.34 2.75e-10 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs9457247 0.967 rs433191 chr6:167409662 T/A cg23791538 chr6:167370224 RNASET2 -0.39 -6.07 -0.32 3.46e-9 Crohn's disease; CRC cis rs853679 0.517 rs7755442 chr6:28039015 T/C cg15786705 chr6:28176104 NA 0.74 9.35 0.46 1.41e-18 Depression; CRC cis rs1448094 0.967 rs2044617 chr12:86324089 T/C cg18827107 chr12:86230957 RASSF9 -0.37 -6.1 -0.32 2.98e-9 Major depressive disorder; CRC cis rs9303280 0.901 rs8067378 chr17:38051348 A/G cg11212589 chr17:38028394 ZPBP2 0.47 8.77 0.44 9.55e-17 Self-reported allergy; CRC cis rs951366 0.903 rs708723 chr1:205739266 C/T cg11965913 chr1:205819406 PM20D1 0.46 6.9 0.36 2.72e-11 Menarche (age at onset); CRC trans rs3780486 1.000 rs3780486 chr9:33139453 C/T cg20290983 chr6:43655470 MRPS18A 1.04 16.88 0.68 1.73e-46 IgG glycosylation; CRC cis rs7178572 0.568 rs12908262 chr15:77493256 G/A cg22256960 chr15:77711686 NA -0.67 -9.56 -0.47 2.93e-19 Type 2 diabetes; CRC cis rs644799 1.000 rs505220 chr11:95563228 T/G cg25622487 chr11:95524042 FAM76B;CEP57 0.76 11.99 0.55 9.59e-28 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs6933660 0.720 rs6936936 chr6:151753395 A/G cg10883421 chr6:151773342 RMND1;C6orf211 0.76 13.33 0.59 1.07e-32 Menarche (age at onset); CRC cis rs1046896 0.553 rs9893885 chr17:80837107 C/T cg08200770 chr17:80723486 TBCD -0.5 -7.57 -0.39 3.71e-13 Glycated hemoglobin levels; CRC trans rs12310956 0.532 rs1906134 chr12:33957135 A/C cg26384229 chr12:38710491 ALG10B 0.52 6.6 0.34 1.64e-10 Morning vs. evening chronotype; CRC cis rs10504229 0.683 rs16921814 chr8:58107421 A/T cg24829409 chr8:58192753 C8orf71 -0.6 -8.48 -0.42 7.49e-16 Developmental language disorder (linguistic errors); CRC cis rs11627756 0.957 rs6575929 chr14:103149447 T/G cg12046867 chr14:103022105 NA 0.41 5.83 0.31 1.29e-8 Mean platelet volume; CRC cis rs9443645 0.901 rs9341754 chr6:79584973 A/C cg05283184 chr6:79620031 NA -0.58 -9.37 -0.46 1.21e-18 Intelligence (multi-trait analysis); CRC cis rs7615952 0.576 rs2276727 chr3:125826243 C/T cg04553112 chr3:125709451 NA -0.51 -5.98 -0.31 5.82e-9 Blood pressure (smoking interaction); CRC cis rs798554 0.757 rs2533879 chr7:2859847 G/A cg14895029 chr7:2775587 GNA12 -0.45 -6.41 -0.33 4.93e-10 Height; CRC cis rs9916302 0.904 rs4795384 chr17:37716771 C/G cg03013999 chr17:37608204 MED1 0.45 6.9 0.36 2.62e-11 Glomerular filtration rate (creatinine); CRC cis rs2625529 0.652 rs2957740 chr15:72307691 A/G cg16672083 chr15:72433130 SENP8 0.44 6.71 0.35 8.3e-11 Red blood cell count; CRC cis rs12476592 0.602 rs1374308 chr2:63895436 G/C cg10828910 chr2:63850056 LOC388955 0.51 6.44 0.33 4.22e-10 Childhood ear infection; CRC cis rs7618915 0.501 rs3733041 chr3:52731598 T/C cg18404041 chr3:52824283 ITIH1 -0.4 -8.31 -0.42 2.46e-15 Bipolar disorder; CRC cis rs6429082 0.846 rs2270538 chr1:235602404 G/A cg26050004 chr1:235667680 B3GALNT2 -0.55 -7.69 -0.39 1.76e-13 Adiposity; CRC trans rs561341 0.609 rs7209493 chr17:30197323 A/G cg00801512 chr17:28996047 NA 0.44 5.97 0.31 6.03e-9 Hip circumference adjusted for BMI; CRC cis rs6938 0.534 rs1127796 chr15:75193004 C/T cg09165964 chr15:75287851 SCAMP5 -0.62 -10.15 -0.49 3.01e-21 Breast cancer; CRC cis rs57221529 0.766 rs17563576 chr5:560476 A/G cg16447950 chr5:562315 NA -0.82 -11.74 -0.54 8.27e-27 Lung disease severity in cystic fibrosis; CRC cis rs7666738 0.830 rs10049985 chr4:99023517 C/T cg17366294 chr4:99064904 C4orf37 0.43 7.29 0.37 2.28e-12 Colonoscopy-negative controls vs population controls; CRC cis rs769267 0.930 rs4808959 chr19:19572108 T/G cg03709012 chr19:19516395 GATAD2A 0.73 11.26 0.53 4.14e-25 Tonsillectomy; CRC cis rs4713675 0.604 rs791902 chr6:33702617 G/A cg14003231 chr6:33640908 ITPR3 -0.4 -6.46 -0.34 3.83e-10 Plateletcrit; CRC cis rs9818758 0.607 rs9855123 chr3:49229457 C/T cg00383909 chr3:49044727 WDR6 1.07 10.43 0.5 3.41e-22 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg00306426 chr1:70687415 SFRS11 0.42 6.44 0.33 4.28e-10 Liver disease severity in Alagille syndrome; CRC cis rs6998277 0.830 rs12543046 chr8:103603809 A/G cg10187029 chr8:103597600 NA -0.9 -14.96 -0.64 5.82e-39 Migraine; CRC trans rs2055729 0.677 rs6601389 chr8:9740636 C/T cg06636001 chr8:8085503 FLJ10661 0.52 6.7 0.35 8.84e-11 Multiple myeloma (hyperdiploidy); CRC cis rs11229555 0.645 rs12285111 chr11:58208385 T/G cg15696309 chr11:58395628 NA -0.82 -10.45 -0.5 2.81e-22 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; CRC cis rs2011503 1.000 rs4808970 chr19:19651140 A/G cg11584989 chr19:19387371 SF4 0.58 6.47 0.34 3.47e-10 Bipolar disorder; CRC cis rs4234798 1.000 rs4234797 chr4:7219907 C/T cg18431297 chr4:7219810 SORCS2 0.62 10.8 0.51 1.81e-23 Insulin-like growth factors; CRC cis rs875971 0.756 rs4718328 chr7:65693337 A/G cg00343986 chr7:65444356 GUSB -0.42 -5.98 -0.31 5.82e-9 Aortic root size; CRC cis rs7811142 0.943 rs111493473 chr7:100049742 A/G cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.92 12.71 0.57 2.17e-30 Platelet count; CRC cis rs1862618 0.853 rs832583 chr5:56178217 A/C cg20203395 chr5:56204925 C5orf35 -0.72 -8.29 -0.42 2.99e-15 Initial pursuit acceleration; CRC cis rs9435341 0.896 rs1623927 chr1:107596120 T/C cg14671364 chr1:107599128 PRMT6 -0.61 -8.19 -0.41 5.85e-15 Facial morphology (factor 21, depth of nasal alae); CRC cis rs2075371 0.501 rs1643057 chr7:134027521 A/G cg02659138 chr7:134003124 SLC35B4 0.35 5.95 0.31 6.93e-9 Mean platelet volume; CRC cis rs1552244 0.935 rs4441636 chr3:10083876 G/A cg02579736 chr3:10068473 FANCD2;CIDECP 1.05 14.15 0.61 8.13e-36 Alzheimer's disease; CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg15527401 chr19:59071099 UBE2M;LOC100131691 -0.5 -6.14 -0.32 2.33e-9 Diisocyanate-induced asthma; CRC cis rs17253792 0.822 rs75999534 chr14:56036413 A/T cg01858014 chr14:56050164 KTN1 -0.87 -6.91 -0.36 2.58e-11 Putamen volume; CRC trans rs800082 1.000 rs800084 chr3:144340494 C/T cg24215973 chr2:240111563 HDAC4 0.52 7.07 0.36 9.59e-12 Smoking behavior; CRC cis rs1451375 0.583 rs7776816 chr7:50583534 G/A cg18232548 chr7:50535776 DDC 0.45 5.84 0.31 1.26e-8 Malaria; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg01656770 chr3:38496051 LOC100128640;ACVR2B 0.45 6.17 0.32 2.03e-9 Response to antipsychotic treatment; CRC cis rs8040855 0.644 rs2342120 chr15:85728820 G/T cg04831495 chr15:85060580 GOLGA6L5 0.4 6.09 0.32 3.15e-9 Bulimia nervosa; CRC cis rs6456156 0.792 rs4710181 chr6:167513998 T/C cg07741184 chr6:167504864 NA 0.49 8.47 0.42 8.25e-16 Primary biliary cholangitis; CRC cis rs17711722 0.727 rs1880555 chr7:65432567 T/C cg05627663 chr7:65219948 SNORA22;CCT6P1 0.49 7.22 0.37 3.55e-12 Calcium levels; CRC cis rs992157 0.835 rs2045434 chr2:219144498 A/G cg04731861 chr2:219085781 ARPC2 0.33 6.94 0.36 2.14e-11 Colorectal cancer; CRC cis rs10046574 0.561 rs9656457 chr7:135202254 T/A cg27474649 chr7:135195673 CNOT4 0.67 6.29 0.33 9.88e-10 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs11098499 0.731 rs6846966 chr4:120293208 A/G cg09307838 chr4:120376055 NA 0.68 10.61 0.5 8.14e-23 Corneal astigmatism; CRC cis rs6499255 0.951 rs74026882 chr16:69635059 A/G cg04110750 chr16:69646130 NFAT5 -0.56 -7.6 -0.39 3.05e-13 IgE levels; CRC cis rs881375 0.654 rs10760126 chr9:123662618 T/C cg14255062 chr9:123606675 PSMD5;LOC253039 0.4 6.3 0.33 9.81e-10 Rheumatoid arthritis; CRC cis rs889312 0.500 rs3099460 chr5:56133748 G/C cg12311346 chr5:56204834 C5orf35 -0.47 -7.03 -0.36 1.17e-11 Breast cancer;Breast cancer (early onset); CRC cis rs1707322 1.000 rs4524994 chr1:46370263 A/G cg06784218 chr1:46089804 CCDC17 0.52 9.1 0.45 8.61e-18 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs60871478 0.947 rs62432866 chr7:809281 T/G cg04727924 chr7:799746 HEATR2 -0.45 -6.78 -0.35 5.73e-11 Cerebrospinal P-tau181p levels; CRC cis rs2795502 0.554 rs1620395 chr10:43341185 G/A cg20628663 chr10:43360327 NA -0.42 -7.48 -0.38 6.69e-13 Blood protein levels; CRC cis rs3820068 0.581 rs1547031 chr1:15918960 G/A cg24675056 chr1:15929824 NA 0.49 6.65 0.34 1.23e-10 Systolic blood pressure; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg25045127 chr20:23402051 NAPB 0.43 6.02 0.31 4.69e-9 Anxiety disorder; CRC cis rs9322193 0.923 rs9800580 chr6:149953981 C/T cg07701084 chr6:150067640 NUP43 0.55 8.04 0.41 1.58e-14 Lung cancer; CRC cis rs35110281 0.633 rs762400 chr21:45113629 C/G cg01579765 chr21:45077557 HSF2BP 0.3 5.73 0.3 2.26e-8 Mean corpuscular volume; CRC cis rs875971 1.000 rs11974264 chr7:65647582 C/G cg12463550 chr7:65579703 CRCP -0.5 -7.26 -0.37 2.87e-12 Aortic root size; CRC cis rs1552244 0.882 rs61429272 chr3:10037320 G/C cg13047869 chr3:10149882 C3orf24 0.51 6.97 0.36 1.74e-11 Alzheimer's disease; CRC cis rs11122272 0.735 rs2486736 chr1:231521478 A/G cg06096015 chr1:231504339 EGLN1 -0.43 -6.42 -0.33 4.83e-10 Hemoglobin concentration; CRC cis rs10504229 1.000 rs72650887 chr8:58177343 G/A cg24829409 chr8:58192753 C8orf71 -0.68 -11.35 -0.53 2.02e-25 Developmental language disorder (linguistic errors); CRC cis rs7647973 1.000 rs13096474 chr3:49443081 C/T cg07636037 chr3:49044803 WDR6 -0.68 -8.56 -0.43 4.29e-16 Menarche (age at onset); CRC cis rs7202877 0.656 rs8048677 chr16:75392028 C/G cg03315344 chr16:75512273 CHST6 0.49 5.85 0.31 1.16e-8 Type 2 diabetes;Type 1 diabetes; CRC cis rs754466 0.957 rs61854183 chr10:79698077 T/C cg17075019 chr10:79541650 NA -0.71 -9.85 -0.48 3.17e-20 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs2734839 0.964 rs2587548 chr11:113292212 G/C cg14159747 chr11:113255604 NA 0.46 8.1 0.41 1.12e-14 Information processing speed; CRC cis rs6662572 0.737 rs4660893 chr1:46327532 T/C cg03123370 chr1:45965343 CCDC163P;MMACHC -0.46 -5.9 -0.31 8.93e-9 Blood protein levels; CRC cis rs11105298 0.891 rs10858872 chr12:89872932 C/T cg00757033 chr12:89920650 WDR51B 0.37 6.13 0.32 2.52e-9 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; CRC cis rs72781680 1.000 rs72781654 chr2:24218099 T/C cg08917208 chr2:24149416 ATAD2B 0.56 6.71 0.35 8.74e-11 Lymphocyte counts; CRC cis rs9443645 0.901 rs971994 chr6:79559602 G/C cg05283184 chr6:79620031 NA -0.57 -9.19 -0.45 4.51e-18 Intelligence (multi-trait analysis); CRC cis rs17376456 0.825 rs28534784 chr5:93063332 C/A cg09848695 chr5:92956644 FAM172A;MIR2277 0.66 6.17 0.32 1.95e-9 Diabetic retinopathy; CRC cis rs7737355 0.898 rs31590 chr5:131005181 A/G cg06307176 chr5:131281290 NA 0.41 5.89 0.31 9.65e-9 Life satisfaction; CRC cis rs1552244 0.572 rs3774208 chr3:10164722 T/G cg18598329 chr3:10140678 FANCD2;C3orf24 -0.91 -10.81 -0.51 1.62e-23 Alzheimer's disease; CRC cis rs2976388 0.590 rs7828042 chr8:143819383 A/G cg10596483 chr8:143751796 JRK -0.45 -6.37 -0.33 6.4e-10 Urinary tract infection frequency; CRC cis rs1223397 0.938 rs35549743 chr6:13294354 C/T cg20827128 chr6:13274284 PHACTR1 0.56 6.5 0.34 3.03e-10 Blood pressure; CRC trans rs2228479 0.867 rs11646448 chr16:89966357 A/T cg21302420 chr1:112162376 RAP1A 0.65 6.17 0.32 1.98e-9 Skin colour saturation; CRC cis rs853679 0.517 rs9380058 chr6:28127444 T/C cg15786705 chr6:28176104 NA 0.78 9.7 0.47 1.01e-19 Depression; CRC cis rs2404602 0.583 rs2176623 chr15:76568579 C/T cg03037974 chr15:76606532 NA 0.81 15.52 0.65 3.8e-41 Blood metabolite levels; CRC trans rs11098499 0.820 rs13122709 chr4:120555356 T/A cg25214090 chr10:38739885 LOC399744 0.65 10.02 0.48 8.28e-21 Corneal astigmatism; CRC cis rs35146811 0.660 rs6465760 chr7:99591418 A/G cg03265037 chr7:99691720 MIR25;MCM7;MIR106B;MIR93 -0.41 -5.69 -0.3 2.74e-8 Coronary artery disease; CRC cis rs7762018 0.607 rs75964125 chr6:170054290 T/A cg19338460 chr6:170058176 WDR27 -1.07 -9.67 -0.47 1.21e-19 Thiazide-induced adverse metabolic effects in hypertensive patients; CRC cis rs10927875 0.722 rs6696912 chr1:16338474 T/C cg10494257 chr1:16342123 HSPB7 0.45 6.0 0.31 5.3e-9 Dilated cardiomyopathy; CRC cis rs4713118 0.869 rs9461405 chr6:27719375 G/T cg25164649 chr6:28176230 NA 0.58 8.3 0.42 2.7e-15 Parkinson's disease; CRC cis rs1059312 1.000 rs3825180 chr12:129279242 A/G cg09035930 chr12:129282057 SLC15A4 -0.54 -9.21 -0.45 3.95e-18 Systemic lupus erythematosus; CRC cis rs10540 1.000 rs71487292 chr11:486076 G/A cg03352830 chr11:487213 PTDSS2 0.66 6.9 0.36 2.74e-11 Body mass index; CRC cis rs1799949 0.550 rs2343818 chr17:41409774 G/A cg25072359 chr17:41440525 NA 0.45 6.57 0.34 1.93e-10 Menopause (age at onset); CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg25809215 chr3:16306823 OXNAD1;DPH3 0.49 6.27 0.33 1.12e-9 Thyroid stimulating hormone; CRC cis rs5750830 0.595 rs4821892 chr22:39795683 G/C cg11247378 chr22:39784982 NA -0.44 -8.05 -0.41 1.5e-14 Intelligence (multi-trait analysis); CRC cis rs9302635 0.513 rs35460163 chr16:72177060 C/T cg23815491 chr16:72088622 HP 0.64 8.12 0.41 9.28e-15 Blood protein levels; CRC cis rs4319547 0.695 rs10773103 chr12:122856532 A/G cg05707623 chr12:122985044 ZCCHC8 0.78 9.46 0.46 6.15e-19 Body mass index; CRC cis rs2404602 0.679 rs12900494 chr15:76912504 A/G cg23625390 chr15:77176239 SCAPER 0.48 7.04 0.36 1.14e-11 Blood metabolite levels; CRC cis rs7618915 0.508 rs13065851 chr3:52644836 T/A cg08222913 chr3:52553049 STAB1 -0.34 -6.15 -0.32 2.2e-9 Bipolar disorder; CRC cis rs9303280 0.806 rs34189114 chr17:38032460 C/T cg00129232 chr17:37814104 STARD3 -0.46 -7.4 -0.38 1.17e-12 Self-reported allergy; CRC cis rs853679 0.760 rs9368563 chr6:28208558 A/G cg02683197 chr6:28174875 NA 0.64 6.54 0.34 2.37e-10 Depression; CRC cis rs13256369 0.760 rs7839473 chr8:8575836 C/T cg18904891 chr8:8559673 CLDN23 0.52 7.12 0.37 6.7e-12 Obesity-related traits; CRC cis rs6951245 0.935 rs79143504 chr7:1110212 A/G cg26224354 chr7:1096374 C7orf50;GPR146 -0.92 -11.43 -0.53 1.08e-25 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs10450586 0.932 rs10767626 chr11:27306545 G/A cg10370305 chr11:27303972 NA 0.37 6.02 0.31 4.69e-9 Total body bone mineral density; CRC cis rs3741798 1.000 rs61922026 chr12:12486428 C/G cg08615371 chr12:12503544 MANSC1 0.98 8.33 0.42 2.16e-15 Cerebrospinal fluid biomarker levels; CRC cis rs8072100 0.651 rs1912484 chr17:45443664 C/G cg25173405 chr17:45401733 C17orf57 -0.47 -7.23 -0.37 3.31e-12 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs12477438 0.520 rs13012481 chr2:99754290 C/A cg26064155 chr2:99771622 LIPT1;TSGA10 0.9 16.76 0.68 4.95e-46 Chronic sinus infection; CRC cis rs8180040 0.764 rs62246375 chr3:47014464 G/A cg27129171 chr3:47204927 SETD2 -0.71 -11.2 -0.53 6.92e-25 Colorectal cancer; CRC cis rs9611565 0.659 rs202653 chr22:41840158 C/T cg06634786 chr22:41940651 POLR3H 0.55 6.7 0.35 9.08e-11 Vitiligo; CRC cis rs12477438 0.520 rs1453563 chr2:99720267 C/G cg26064155 chr2:99771622 LIPT1;TSGA10 0.77 13.1 0.59 7.65e-32 Chronic sinus infection; CRC trans rs9929218 0.551 rs2296406 chr16:68721340 G/A cg04657470 chr2:198365150 HSPE1;HSPD1 1.22 32.61 0.87 4.43e-105 Colorectal cancer; CRC cis rs9902453 0.740 rs2729446 chr17:28102499 A/C cg26525008 chr17:28256777 EFCAB5;SSH2 -0.72 -12.11 -0.56 3.76e-28 Coffee consumption (cups per day); CRC trans rs11039798 0.588 rs584899 chr11:48431408 T/C cg03929089 chr4:120376271 NA -0.64 -7.11 -0.36 7.43e-12 Axial length; CRC cis rs2243480 0.901 rs73142137 chr7:65343442 A/T cg18252515 chr7:66147081 NA -1.17 -13.25 -0.59 2.03e-32 Diabetic kidney disease; CRC cis rs1862618 0.853 rs832565 chr5:56150803 T/G cg03609598 chr5:56110824 MAP3K1 -0.82 -9.92 -0.48 1.82e-20 Initial pursuit acceleration; CRC cis rs1042058 0.565 rs2480297 chr10:30754512 A/G cg18806716 chr10:30721971 MAP3K8 -0.59 -8.3 -0.42 2.72e-15 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; CRC cis rs9329221 0.905 rs4841329 chr8:10253098 A/G cg27411982 chr8:10470053 RP1L1 -0.36 -5.81 -0.31 1.45e-8 Neuroticism; CRC cis rs12220238 1.000 rs11000925 chr10:75972601 G/A cg19889307 chr10:75911429 ADK;AP3M1 0.54 5.61 0.3 4.26e-8 Soluble interleukin-2 receptor subunit alpha; CRC cis rs863345 0.604 rs975118 chr1:158511445 G/A cg12129480 chr1:158549410 OR10X1 -0.3 -6.27 -0.33 1.12e-9 Pneumococcal bacteremia; CRC cis rs3857067 0.806 rs722486 chr4:95092315 G/A cg11021082 chr4:95130006 SMARCAD1 -0.49 -7.65 -0.39 2.22e-13 QT interval; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg18732869 chr19:6739680 TRIP10 0.37 6.09 0.32 3.24e-9 Liver disease severity in Alagille syndrome; CRC cis rs6951245 1.000 rs77346188 chr7:1114023 C/A cg04025307 chr7:1156635 C7orf50 0.68 7.22 0.37 3.65e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg12059507 chr11:62606662 WDR74 0.39 6.22 0.32 1.5e-9 Liver disease severity in Alagille syndrome; CRC cis rs4665809 1.000 rs4233709 chr2:26291493 C/T cg25036284 chr2:26402008 FAM59B 0.45 5.93 0.31 7.55e-9 Gut microbiome composition (summer); CRC cis rs9372498 0.536 rs9489467 chr6:118935206 C/T cg24463073 chr6:118973353 C6orf204 0.48 6.22 0.32 1.49e-9 Diastolic blood pressure; CRC cis rs7647973 0.588 rs4855848 chr3:49653457 C/T cg03060546 chr3:49711283 APEH 0.68 8.22 0.41 4.71e-15 Menarche (age at onset); CRC cis rs7677751 0.806 rs4864857 chr4:55089814 T/C cg17187183 chr4:55093834 PDGFRA 0.52 7.54 0.38 4.67e-13 Corneal astigmatism; CRC cis rs947211 0.846 rs708726 chr1:205762139 G/T cg17178900 chr1:205818956 PM20D1 -0.39 -5.69 -0.3 2.85e-8 Parkinson's disease; CRC cis rs9291683 0.609 rs13141233 chr4:10028729 T/C cg11266682 chr4:10021025 SLC2A9 0.54 11.41 0.53 1.28e-25 Bone mineral density; CRC cis rs12540874 1.000 rs12540874 chr7:50664922 A/G cg18232548 chr7:50535776 DDC -0.46 -6.72 -0.35 8.19e-11 Systemic sclerosis; CRC cis rs2067615 0.524 rs10861646 chr12:107071182 C/T cg15890332 chr12:107067104 RFX4 0.32 5.71 0.3 2.58e-8 Heart rate; CRC cis rs208515 0.525 rs10755508 chr6:66675790 T/C cg07460842 chr6:66804631 NA 0.92 11.59 0.54 2.7e-26 Exhaled nitric oxide levels; CRC cis rs9910055 0.529 rs425038 chr17:42182028 T/C cg09913183 chr17:42254507 C17orf65;ASB16 -0.48 -6.42 -0.33 4.69e-10 Total body bone mineral density; CRC cis rs9527 0.590 rs4917992 chr10:104786313 G/A cg15744005 chr10:104629667 AS3MT -0.29 -5.81 -0.3 1.51e-8 Arsenic metabolism; CRC cis rs1552244 1.000 rs58275763 chr3:10143274 C/T cg00166722 chr3:10149974 C3orf24 0.69 9.38 0.46 1.12e-18 Alzheimer's disease; CRC cis rs713587 0.520 rs1530016 chr2:25305756 C/T cg22495460 chr2:25135724 ADCY3 0.43 6.45 0.34 3.96e-10 Body mass index in non-asthmatics; CRC cis rs28375034 1 rs28375034 chr7:132886052 G/A cg10665199 chr7:133106180 EXOC4 0.56 5.83 0.31 1.3e-8 Schizophrenia; CRC cis rs6963495 0.615 rs2697021 chr7:105151029 A/C cg02135003 chr7:105160482 PUS7 -0.52 -8.18 -0.41 6.39e-15 Bipolar disorder (body mass index interaction); CRC trans rs3733585 0.753 rs12500805 chr4:10017979 C/T cg26043149 chr18:55253948 FECH 0.48 7.06 0.36 1.01e-11 Cleft plate (environmental tobacco smoke interaction); CRC cis rs11971779 0.680 rs6467848 chr7:139080205 T/A cg23387468 chr7:139079360 LUC7L2 0.41 6.98 0.36 1.63e-11 Diisocyanate-induced asthma; CRC cis rs35306767 0.715 rs17293580 chr10:1034895 T/C cg26597838 chr10:835615 NA 0.91 10.51 0.5 1.81e-22 Eosinophil percentage of granulocytes; CRC cis rs394563 0.601 rs376269 chr6:149795154 C/T cg11245181 chr6:149772854 ZC3H12D -0.45 -7.16 -0.37 5.41e-12 Dupuytren's disease; CRC cis rs1580019 0.961 rs1610143 chr7:32498331 C/T cg06627557 chr7:32535165 LSM5;AVL9 0.71 11.2 0.53 6.71e-25 Cognitive ability; CRC cis rs10504229 0.683 rs56741275 chr8:58136108 C/G cg04204079 chr8:58130323 NA -0.45 -5.78 -0.3 1.71e-8 Developmental language disorder (linguistic errors); CRC cis rs274567 0.501 rs272855 chr5:131687175 C/T cg11843238 chr5:131593191 PDLIM4 0.43 7.01 0.36 1.4e-11 Blood metabolite levels; CRC cis rs9491140 0.539 rs911959 chr6:124688755 A/G cg05308643 chr6:124982296 NKAIN2 0.51 7.3 0.37 2.17e-12 Neuroticism; CRC cis rs7208859 0.673 rs73277967 chr17:29184166 T/A cg01831904 chr17:28903510 LRRC37B2 -0.55 -5.72 -0.3 2.33e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs394563 0.625 rs384306 chr6:149796140 A/G cg07828024 chr6:149772892 ZC3H12D -0.37 -6.23 -0.33 1.39e-9 Dupuytren's disease; CRC cis rs597539 0.617 rs672853 chr11:68636362 G/A cg06028808 chr11:68637592 NA 0.39 5.87 0.31 1.09e-8 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs116095464 0.558 rs73031482 chr5:227594 G/A cg22857025 chr5:266934 NA -1.16 -16.31 -0.67 2.94e-44 Breast cancer; CRC cis rs2839186 0.588 rs2839140 chr21:47616080 G/A cg11766577 chr21:47581405 C21orf56 0.4 6.43 0.33 4.52e-10 Testicular germ cell tumor; CRC cis rs6840360 0.582 rs1372976 chr4:152451453 G/A cg09659197 chr4:152720779 NA 0.33 6.47 0.34 3.61e-10 Intelligence (multi-trait analysis); CRC cis rs1018836 0.886 rs10112242 chr8:91642631 G/C cg16814680 chr8:91681699 NA -0.75 -11.83 -0.55 3.74e-27 Ejection fraction in Tripanosoma cruzi seropositivity; CRC cis rs4443100 0.670 rs8139280 chr22:23405957 G/A cg14186256 chr22:23484241 RTDR1 0.46 5.87 0.31 1.06e-8 Serum parathyroid hormone levels; CRC cis rs6988985 0.728 rs1134096 chr8:143954223 C/A cg10324643 chr8:143916377 GML 0.35 5.84 0.31 1.25e-8 Plasma androstenedione levels in resected early stage-receptor positive breast cancer; CRC cis rs769267 0.965 rs6511026 chr19:19391402 C/T cg03709012 chr19:19516395 GATAD2A 0.72 10.98 0.52 4.29e-24 Tonsillectomy; CRC cis rs172166 0.611 rs203883 chr6:28078356 A/G cg15845792 chr6:28175446 NA 0.8 11.59 0.54 2.82e-26 Cardiac Troponin-T levels; CRC cis rs734999 0.588 rs3748819 chr1:2524966 C/T cg18854424 chr1:2615690 NA 0.48 9.47 0.46 5.67e-19 Ulcerative colitis; CRC cis rs3820068 0.603 rs6429769 chr1:15968610 C/G cg27534772 chr1:16042836 PLEKHM2 0.53 10.39 0.5 4.59e-22 Systolic blood pressure; CRC cis rs10779751 1.000 rs11121706 chr1:11302065 C/T cg08854313 chr1:11322531 MTOR 0.69 9.84 0.48 3.33e-20 Body mass index; CRC trans rs2303319 0.504 rs12467613 chr2:162603216 G/T cg22988483 chr14:93581567 ITPK1 -0.66 -6.07 -0.32 3.52e-9 Cognitive function; CRC cis rs929354 0.742 rs10251112 chr7:156963524 A/G cg17757837 chr7:157058334 UBE3C 0.75 12.76 0.58 1.46e-30 Body mass index; CRC cis rs9894429 0.869 rs9748184 chr17:79596280 A/G cg21984481 chr17:79567631 NPLOC4 -0.53 -9.8 -0.48 4.71e-20 Eye color traits; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg01773951 chr1:247094386 AHCTF1 0.45 6.24 0.33 1.36e-9 Response to antipsychotic treatment; CRC cis rs3018066 0.867 rs4508971 chr4:107037815 C/T cg01869342 chr4:106983673 TBCK 0.36 5.61 0.3 4.32e-8 Cancer; CRC cis rs921968 0.541 rs514356 chr2:219375018 C/T cg02176678 chr2:219576539 TTLL4 0.54 8.69 0.43 1.78e-16 Mean corpuscular hemoglobin concentration; CRC cis rs2857891 0.697 rs1004754 chr11:6946248 T/C cg14883916 chr11:6947541 ZNF215 0.6 6.41 0.33 4.9e-10 Response to cytadine analogues (cytosine arabinoside); CRC cis rs6502050 0.604 rs9897355 chr17:80078095 G/A cg19223190 chr17:80058835 NA -0.39 -6.06 -0.32 3.63e-9 Life satisfaction; CRC cis rs7264396 0.790 rs12480622 chr20:34234620 T/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.55 -8.71 -0.43 1.52e-16 Total cholesterol levels; CRC cis rs9326248 1.000 rs9326248 chr11:116999225 A/C cg15534755 chr11:117069859 TAGLN 0.33 6.09 0.32 3.09e-9 Blood protein levels; CRC cis rs11122272 0.733 rs2749700 chr1:231522734 A/G cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.56 -8.44 -0.42 1.03e-15 Hemoglobin concentration; CRC cis rs35264875 0.950 rs72928659 chr11:68852358 C/T cg23740940 chr11:68924746 NA 0.44 5.77 0.3 1.82e-8 Blond vs. brown hair color; CRC cis rs9467773 1.000 rs3736781 chr6:26505362 G/A cg09904177 chr6:26538194 HMGN4 0.85 14.75 0.63 3.95e-38 Intelligence (multi-trait analysis); CRC cis rs4700695 1.000 rs12518359 chr5:65397909 T/C cg21114390 chr5:65439923 SFRS12 -0.49 -6.35 -0.33 7.17e-10 Facial morphology (factor 19); CRC cis rs9372498 0.706 rs9489396 chr6:118761703 A/C cg10217327 chr6:118973057 C6orf204 0.51 5.75 0.3 2e-8 Diastolic blood pressure; CRC cis rs6951245 1.000 rs113858334 chr7:1073476 A/G cg26224354 chr7:1096374 C7orf50;GPR146 -0.88 -11.08 -0.52 1.89e-24 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs447735 0.587 rs11640702 chr16:89729169 A/G cg01097406 chr16:89675127 NA -0.38 -7.23 -0.37 3.43e-12 Hemoglobin concentration; CRC cis rs35306767 0.761 rs34480046 chr10:1027440 A/G cg20503657 chr10:835505 NA 0.94 10.72 0.51 3.35e-23 Eosinophil percentage of granulocytes; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg21100532 chr2:192015514 STAT4 0.39 6.14 0.32 2.32e-9 Liver disease severity in Alagille syndrome; CRC cis rs4975709 0.610 rs4975705 chr5:1860359 T/C cg15595755 chr5:1867978 NA 0.37 6.14 0.32 2.38e-9 Cardiovascular disease risk factors; CRC cis rs12142240 0.698 rs55670684 chr1:46835139 C/T cg14993813 chr1:46806288 NSUN4 -0.5 -6.25 -0.33 1.26e-9 Menopause (age at onset); CRC cis rs8177253 1.000 rs1525892 chr3:133484712 C/T cg08048268 chr3:133502702 NA -0.39 -7.38 -0.38 1.3e-12 Iron status biomarkers; CRC cis rs4731207 0.698 rs7794631 chr7:124551925 T/C cg23710748 chr7:124431027 NA -0.37 -6.0 -0.31 5.3300000000000004e-09 Cutaneous malignant melanoma; CRC cis rs897984 0.542 rs3751855 chr16:31091209 T/C cg02466173 chr16:30829666 NA -0.59 -8.97 -0.44 2.32e-17 Dementia with Lewy bodies; CRC cis rs929354 0.772 rs6971896 chr7:156978412 C/T cg17757837 chr7:157058334 UBE3C 0.74 12.6 0.57 5.83e-30 Body mass index; CRC cis rs6570726 0.537 rs1280279 chr6:145884048 G/T cg23711669 chr6:146136114 FBXO30 0.6 8.09 0.41 1.17e-14 Lobe attachment (rater-scored or self-reported); CRC cis rs2239547 0.603 rs12489490 chr3:53064022 C/A cg15147215 chr3:52552868 STAB1 -0.49 -6.49 -0.34 3.11e-10 Schizophrenia; CRC cis rs6951245 0.935 rs78573577 chr7:1089087 C/A cg22907277 chr7:1156413 C7orf50 0.71 7.23 0.37 3.34e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs9649213 0.593 rs7789380 chr7:97956180 G/A cg24562669 chr7:97807699 LMTK2 0.42 7.02 0.36 1.3e-11 Prostate cancer (SNP x SNP interaction); CRC cis rs2797160 0.651 rs1343121 chr6:126036184 C/T cg05901451 chr6:126070800 HEY2 0.48 7.72 0.39 1.38e-13 Endometrial cancer; CRC cis rs7666738 0.830 rs17027102 chr4:98919221 A/G cg05340658 chr4:99064831 C4orf37 -0.59 -9.04 -0.45 1.41e-17 Colonoscopy-negative controls vs population controls; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg25749966 chr3:52443976 BAP1;PHF7 -0.39 -6.1 -0.32 3.03e-9 Myopia (pathological); CRC trans rs800082 1.000 rs1405599 chr3:144328759 T/C cg24215973 chr2:240111563 HDAC4 -0.54 -7.69 -0.39 1.75e-13 Smoking behavior; CRC cis rs6088590 0.561 rs6059918 chr20:33150503 C/T cg24642439 chr20:33292090 TP53INP2 0.41 7.02 0.36 1.24e-11 Coronary artery disease; CRC trans rs6940638 0.956 rs13207365 chr6:27030980 T/C cg06606381 chr12:133084897 FBRSL1 -0.6 -6.52 -0.34 2.71e-10 Intelligence (multi-trait analysis); CRC cis rs780096 0.565 rs13022659 chr2:27743630 C/T cg02592271 chr2:27665507 KRTCAP3 -0.27 -5.95 -0.31 7e-9 Total body bone mineral density; CRC cis rs2658782 0.724 rs2248655 chr11:93254612 T/C cg15737290 chr11:93063684 CCDC67 0.56 7.74 0.39 1.23e-13 Pulmonary function decline; CRC cis rs1003719 0.788 rs3787783 chr21:38462959 T/A cg10648535 chr21:38446584 PIGP;TTC3 0.52 7.36 0.38 1.48e-12 Eye color traits; CRC cis rs66569888 0.754 rs6719028 chr2:106895212 T/C cg23109721 chr2:106886537 NA 0.49 6.83 0.35 4.18e-11 Facial morphology (factor 23); CRC cis rs853679 0.517 rs3734573 chr6:28059437 T/C cg18032046 chr6:28092343 ZSCAN16 -0.5 -5.84 -0.31 1.26e-8 Depression; CRC cis rs12681287 0.609 rs13279850 chr8:87477800 C/T cg27223183 chr8:87520930 FAM82B -0.51 -7.38 -0.38 1.33e-12 Caudate activity during reward; CRC cis rs7607369 0.679 rs6751527 chr2:219630965 C/G cg02176678 chr2:219576539 TTLL4 0.56 8.8 0.44 7.93e-17 Red blood cell count;Amyotrophic lateral sclerosis; CRC cis rs780096 0.565 rs10169261 chr2:27727314 C/T cg27432699 chr2:27873401 GPN1 -0.55 -8.41 -0.42 1.31e-15 Total body bone mineral density; CRC cis rs62229266 0.740 rs4817759 chr21:37389559 G/A cg08632701 chr21:37451849 NA -0.42 -6.6 -0.34 1.68e-10 Mitral valve prolapse; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg08348959 chr3:10290087 TATDN2 0.43 6.0 0.31 5.2e-9 Anxiety disorder; CRC cis rs4727027 0.933 rs12667123 chr7:148850621 G/A cg12479418 chr7:148823350 ZNF425;ZNF398 0.43 5.84 0.31 1.26e-8 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC cis rs12760731 0.720 rs12048459 chr1:178412702 T/C cg00404053 chr1:178313656 RASAL2 0.95 9.76 0.47 6.35e-20 Obesity-related traits; CRC cis rs9894429 0.646 rs58398000 chr17:79576923 G/A cg09655341 chr17:79618100 PDE6G 0.36 6.23 0.32 1.46e-9 Eye color traits; CRC cis rs17376456 0.877 rs10057814 chr5:93399092 C/G cg25358565 chr5:93447407 FAM172A 1.01 10.65 0.51 5.86e-23 Diabetic retinopathy; CRC cis rs3126085 0.935 rs12729662 chr1:152185750 G/A cg09127314 chr1:152161683 NA -0.5 -5.85 -0.31 1.21e-8 Atopic dermatitis; CRC cis rs13191362 0.935 rs35537826 chr6:163145867 G/A cg23758597 chr6:163146217 PARK2 -0.56 -6.32 -0.33 8.47e-10 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs55788414 0.932 rs8059559 chr16:81185684 G/A cg06400318 chr16:81190750 PKD1L2 0.55 6.75 0.35 6.88e-11 Left ventricular obstructive tract defect (maternal effect); CRC cis rs10791323 0.592 rs2851115 chr11:133705381 C/A cg06766960 chr11:133703094 NA -0.36 -6.03 -0.32 4.38e-9 Childhood ear infection; CRC cis rs12612619 0.732 rs2289360 chr2:27302165 T/C cg00617064 chr2:27272375 NA -0.38 -6.18 -0.32 1.91e-9 Venous thromboembolism adjusted for sickle cell variant rs77121243-T; CRC cis rs78077440 0.932 rs78162562 chr5:40334428 A/C cg09067459 chr5:40385259 NA -0.53 -5.83 -0.31 1.32e-8 Multiple sclerosis; CRC cis rs8072100 0.667 rs1912485 chr17:45515678 T/G cg08085267 chr17:45401833 C17orf57 -0.58 -8.68 -0.43 1.92e-16 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg03919779 chr17:16284127 UBB 0.44 7.05 0.36 1.03e-11 Liver disease severity in Alagille syndrome; CRC cis rs933688 1.000 rs985434 chr5:90744509 A/G cg26981201 chr5:90679533 LOC100129716;ARRDC3 0.98 15.01 0.64 3.59e-39 Smoking behavior; CRC cis rs7493 0.755 rs17166859 chr7:94995519 T/C cg20119798 chr7:94954144 PON1 -0.44 -5.61 -0.3 4.36e-8 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs9733 0.596 rs6661872 chr1:150628357 C/G cg15448220 chr1:150897856 SETDB1 0.45 6.43 0.33 4.42e-10 Tonsillectomy; CRC cis rs6912958 0.535 rs448580 chr6:88040399 A/C cg08069147 chr6:88032118 GJB7;C6orf162 0.68 10.65 0.51 5.82e-23 Monocyte percentage of white cells; CRC cis rs931127 0.666 rs7932857 chr11:65457493 A/C cg27068330 chr11:65405492 SIPA1 -0.43 -5.91 -0.31 8.45e-9 Systemic lupus erythematosus; CRC cis rs13118159 0.872 rs1882105 chr4:1345956 T/C cg23123621 chr4:1343375 KIAA1530 0.36 6.19 0.32 1.82e-9 Longevity; CRC cis rs1124376 1.000 rs17006623 chr3:20161043 G/T cg05072819 chr3:20081367 KAT2B 0.51 6.15 0.32 2.22e-9 Bipolar disorder and schizophrenia; CRC cis rs10489202 0.583 rs201539 chr1:167995407 A/G cg24449463 chr1:168025552 DCAF6 -0.6 -9.11 -0.45 8.13e-18 Schizophrenia; CRC cis rs72781680 1.000 rs72781679 chr2:24237712 G/A cg08917208 chr2:24149416 ATAD2B 0.99 9.54 0.47 3.31e-19 Lymphocyte counts; CRC cis rs1107366 1.000 rs1107364 chr3:125904263 G/A cg21601837 chr3:125900065 ALDH1L1 -0.35 -5.62 -0.3 4.16e-8 Metabolite levels; CRC cis rs873946 0.586 rs57431984 chr10:134567697 C/T cg06453172 chr10:134556979 INPP5A -0.69 -8.23 -0.41 4.32e-15 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CRC cis rs853679 0.546 rs200948 chr6:27835272 T/C cg03623178 chr6:28175578 NA 0.78 6.65 0.34 1.22e-10 Depression; CRC cis rs12682352 0.602 rs6988939 chr8:8666916 C/T cg06636001 chr8:8085503 FLJ10661 0.55 8.83 0.44 6.53e-17 Neuroticism; CRC cis rs910316 1.000 rs12590452 chr14:75548756 T/C cg03030879 chr14:75389066 RPS6KL1 -0.46 -7.33 -0.37 1.8e-12 Height; CRC cis rs7917772 0.503 rs11191325 chr10:104302933 G/A cg11453585 chr10:104263688 ACTR1A;SUFU 0.9 16.75 0.68 5.87e-46 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC cis rs2252790 1.000 rs12213442 chr6:116636907 G/A cg18764771 chr6:116381957 FRK 0.21 5.76 0.3 1.94e-8 Fast beta electroencephalogram; CRC cis rs2840044 1.000 rs9913003 chr17:33893904 C/A cg05299278 chr17:33885742 SLFN14 -0.42 -6.31 -0.33 9.17e-10 Response to radiotherapy in cancer (late toxicity); CRC cis rs8180040 0.726 rs4234465 chr3:47026885 C/G cg02527881 chr3:46936655 PTH1R -0.37 -6.82 -0.35 4.25e-11 Colorectal cancer; CRC cis rs3736485 0.966 rs4775958 chr15:51891562 G/C cg08986416 chr15:51914746 DMXL2 -0.45 -6.37 -0.33 6.35e-10 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs2303759 0.709 rs10422677 chr19:49824290 C/T cg24324837 chr19:49891574 CCDC155 0.53 6.92 0.36 2.41e-11 Multiple sclerosis; CRC cis rs1552244 0.935 rs6805869 chr3:10119917 T/C cg10729496 chr3:10149963 C3orf24 0.5 6.81 0.35 4.67e-11 Alzheimer's disease; CRC cis rs801193 0.805 rs12532355 chr7:66070584 C/G cg00343986 chr7:65444356 GUSB -0.48 -7.1 -0.36 7.51e-12 Aortic root size; CRC cis rs9372498 0.536 rs72952733 chr6:118834452 A/G cg24463073 chr6:118973353 C6orf204 0.55 7.27 0.37 2.59e-12 Diastolic blood pressure; CRC cis rs67340775 0.541 rs169287 chr6:27854760 C/A cg26587870 chr6:27730563 NA -0.56 -6.46 -0.34 3.67e-10 Lung cancer in ever smokers; CRC cis rs7927771 0.542 rs7102205 chr11:47745374 C/T cg20307385 chr11:47447363 PSMC3 0.45 6.38 0.33 6e-10 Subjective well-being; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg03535933 chr8:67974296 COPS5 0.45 6.67 0.35 1.11e-10 Liver disease severity in Alagille syndrome; CRC cis rs9311474 0.508 rs6788887 chr3:52605005 T/C cg18404041 chr3:52824283 ITIH1 -0.41 -8.69 -0.43 1.71e-16 Electroencephalogram traits; CRC cis rs1950626 0.716 rs34572720 chr14:101447150 G/A cg02351406 chr14:101447389 SNORD114-20;SNORD114-21 0.97 15.89 0.66 1.42e-42 Pelvic organ prolapse (moderate/severe); CRC cis rs59104589 0.617 rs57696929 chr2:242380382 T/C cg19488206 chr2:242435732 STK25 0.46 6.8 0.35 4.97e-11 Fibrinogen levels; CRC cis rs9916302 0.904 rs13341996 chr17:37536862 C/T cg15445000 chr17:37608096 MED1 -0.44 -9.71 -0.47 9.36e-20 Glomerular filtration rate (creatinine); CRC cis rs4731207 0.596 rs6948283 chr7:124679523 T/C cg23710748 chr7:124431027 NA -0.39 -6.22 -0.32 1.54e-9 Cutaneous malignant melanoma; CRC cis rs2839186 0.721 rs3788252 chr21:47661235 C/T cg13126279 chr21:47581558 C21orf56 -0.52 -8.4 -0.42 1.4e-15 Testicular germ cell tumor; CRC cis rs8031584 0.678 rs8028173 chr15:31155749 A/G cg08109568 chr15:31115862 NA -0.68 -10.64 -0.51 6.3e-23 Huntington's disease progression; CRC trans rs561341 0.883 rs4450460 chr17:30201309 C/T cg20587970 chr11:113659929 NA 0.91 11.17 0.52 8.7e-25 Hip circumference adjusted for BMI; CRC cis rs28374715 0.681 rs59000092 chr15:41626148 A/G cg18705301 chr15:41695430 NDUFAF1 -0.85 -14.32 -0.62 1.68e-36 Ulcerative colitis; CRC cis rs6700896 0.898 rs1938495 chr1:66106469 A/G cg04111102 chr1:66153794 NA 0.32 5.66 0.3 3.22e-8 C-reactive protein;Mean corpuscular volume;Mean corpuscular hemoglobin; CRC cis rs2197308 0.740 rs11182251 chr12:37919611 C/T cg26384229 chr12:38710491 ALG10B -0.64 -9.61 -0.47 1.96e-19 Morning vs. evening chronotype; CRC cis rs9322193 0.923 rs10782314 chr6:150056663 C/T cg00933542 chr6:150070202 PCMT1 0.33 6.61 0.34 1.54e-10 Lung cancer; CRC trans rs2303319 0.504 rs62187612 chr2:162432494 A/G cg03757145 chr4:76555832 CDKL2 -0.68 -6.04 -0.32 4.06e-9 Cognitive function; CRC cis rs1965732 1.000 rs11696000 chr2:3709907 A/G cg25251562 chr2:3704773 ALLC -0.44 -6.37 -0.33 6.33e-10 Response to inhaled corticosteroid treatment in asthma (change in FEV1); CRC cis rs4478858 0.684 rs4949372 chr1:31738857 G/A cg00250761 chr1:31883323 NA -0.44 -8.6 -0.43 3.28e-16 Alcohol dependence; CRC cis rs7727544 0.836 rs10463892 chr5:131598705 T/C cg18301423 chr5:131593218 PDLIM4 0.3 5.75 0.3 2e-8 Blood metabolite levels; CRC cis rs4332037 0.539 rs11762545 chr7:2060775 C/T cg13880726 chr7:1868755 MAD1L1 -0.46 -5.68 -0.3 2.95e-8 Bipolar disorder; CRC cis rs12477438 0.501 rs13008171 chr2:99743419 G/A cg14399236 chr2:99771627 LIPT1;TSGA10 0.73 12.05 0.55 6.15e-28 Chronic sinus infection; CRC cis rs853679 0.517 rs9393901 chr6:28136797 A/G cg12172441 chr6:28176163 NA 0.64 7.53 0.38 5.03e-13 Depression; CRC cis rs9291683 0.610 rs993173 chr4:10323935 T/C cg00071950 chr4:10020882 SLC2A9 -0.5 -8.47 -0.42 8.56e-16 Bone mineral density; CRC cis rs17270561 0.636 rs12194699 chr6:25729229 G/C cg16482183 chr6:26056742 HIST1H1C 0.83 10.59 0.5 9.49e-23 Iron status biomarkers; CRC cis rs3008870 1.000 rs4655663 chr1:67430103 C/T cg08660285 chr1:67390436 MIER1;WDR78 1.01 14.73 0.63 4.72e-38 Lymphocyte percentage of white cells; CRC cis rs12692738 0.526 rs355844 chr2:165623322 T/G cg03182029 chr2:165697222 COBLL1 0.51 6.09 0.32 3.18e-9 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);Waist-to-hip ratio adjusted for BMI in non-smokers;Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction);Waist-to-hip ratio adjusted for body mass index; CRC cis rs4975709 0.589 rs4975744 chr5:1860049 A/G cg15595755 chr5:1867978 NA 0.36 5.95 0.31 6.87e-9 Cardiovascular disease risk factors; CRC cis rs7680126 0.632 rs11731464 chr4:10148376 G/A cg11266682 chr4:10021025 SLC2A9 -0.43 -6.0 -0.31 5.24e-9 Urate levels in lean individuals;Urate levels in overweight individuals;Urate levels in obese individuals; CRC cis rs11583043 1.000 rs6660290 chr1:101483512 A/G cg16556008 chr1:101360663 SLC30A7;EXTL2 -0.47 -5.86 -0.31 1.11e-8 Ulcerative colitis;Inflammatory bowel disease; CRC cis rs2075371 0.933 rs1421482 chr7:133964383 A/G cg11752832 chr7:134001865 SLC35B4 0.43 6.65 0.34 1.26e-10 Mean platelet volume; CRC cis rs853679 0.517 rs7755442 chr6:28039015 T/C cg12172441 chr6:28176163 NA 0.6 7.21 0.37 3.76e-12 Depression; CRC cis rs10540 0.908 rs35608427 chr11:498976 T/C cg03352830 chr11:487213 PTDSS2 0.66 7.62 0.39 2.69e-13 Body mass index; CRC cis rs17780086 0.527 rs72827712 chr17:30538600 A/G cg23018236 chr17:30244563 NA -0.58 -5.94 -0.31 7.07e-9 Height; CRC cis rs7586879 0.639 rs4077678 chr2:25122840 C/G cg22495460 chr2:25135724 ADCY3 -0.87 -17.17 -0.69 1.23e-47 Body mass index; CRC cis rs10078 0.515 rs2672739 chr5:443447 A/C cg14122633 chr5:456516 EXOC3 -0.48 -5.62 -0.3 4.15e-8 Fat distribution (HIV); CRC cis rs9914988 0.725 rs66531973 chr17:27125993 G/T cg12682573 chr17:27188876 MIR451;MIR144 0.58 8.06 0.41 1.41e-14 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs2294693 0.947 rs9381025 chr6:40986623 C/T cg14769373 chr6:40998127 UNC5CL -0.5 -6.9 -0.36 2.65e-11 Gastric cancer;Non-cardia gastric cancer; CRC cis rs13256369 0.951 rs13260947 chr8:8565883 A/G cg06671706 chr8:8559999 CLDN23 0.62 9.28 0.46 2.32e-18 Obesity-related traits; CRC cis rs11764590 0.694 rs6972969 chr7:2099331 A/G cg14004847 chr7:1930337 MAD1L1 -0.42 -5.67 -0.3 3.15e-8 Neuroticism; CRC cis rs4588572 0.644 rs2115435 chr5:77723700 A/C cg11446398 chr5:77624930 NA 0.45 6.43 0.33 4.41e-10 Triglycerides; CRC cis rs2882667 0.898 rs6882526 chr5:138382368 A/G cg09476006 chr5:138032270 NA 0.44 7.4 0.38 1.12e-12 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs1799949 1.000 rs35070007 chr17:41316747 C/G cg25072359 chr17:41440525 NA -0.52 -8.32 -0.42 2.35e-15 Menopause (age at onset); CRC cis rs9486715 1.000 rs6905737 chr6:97066659 A/T cg06623918 chr6:96969491 KIAA0776 -0.9 -14.68 -0.63 6.9e-38 Headache; CRC cis rs798502 0.541 rs2644307 chr7:2832973 G/A cg19717773 chr7:2847554 GNA12 -0.45 -7.41 -0.38 1.11e-12 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Inflammatory bowel disease;Waist circumference adjusted for BMI in non-smokers;Ulcerative colitis;Waist circumference adjusted for body mass index;Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction); CRC cis rs780096 0.506 rs1647285 chr2:27714511 A/C cg22903471 chr2:27725779 GCKR -0.37 -6.05 -0.32 3.96e-9 Total body bone mineral density; CRC cis rs4073416 0.542 rs7150094 chr14:65936361 A/G cg03016385 chr14:66212404 NA -0.44 -5.97 -0.31 6.12e-9 N-glycan levels; CRC cis rs6500602 0.826 rs7205189 chr16:4460114 A/G cg14951292 chr16:4525986 HMOX2;NMRAL1 0.66 8.52 0.43 5.64e-16 Schizophrenia; CRC cis rs727563 0.520 rs132773 chr22:42031768 T/A cg03806693 chr22:41940476 POLR3H 1.01 12.62 0.57 4.94e-30 Crohn's disease;Inflammatory bowel disease; CRC cis rs11123610 0.520 rs66557864 chr2:3720812 C/A cg00999904 chr2:3704751 ALLC -0.53 -6.66 -0.34 1.15e-10 Response to inhaled corticosteroid treatment in asthma (change in FEV1); CRC cis rs951366 0.585 rs72750964 chr1:205675240 C/T cg24503407 chr1:205819492 PM20D1 0.81 12.04 0.55 6.78e-28 Menarche (age at onset); CRC cis rs853679 0.517 rs9348796 chr6:28126202 A/G cg15786705 chr6:28176104 NA 0.78 9.83 0.48 3.57e-20 Depression; CRC cis rs10089 1.000 rs10061367 chr5:127449021 T/C cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.71 9.88 0.48 2.54e-20 Ileal carcinoids; CRC cis rs1552244 1.000 rs7652935 chr3:10151138 T/C cg08888203 chr3:10149979 C3orf24 0.71 9.52 0.46 3.79e-19 Alzheimer's disease; CRC cis rs2070997 0.715 rs11244164 chr9:133736116 A/G cg01000188 chr9:133769184 QRFP 0.59 8.56 0.43 4.32e-16 Response to amphetamines; CRC cis rs7591163 1.000 rs4487084 chr2:228713179 G/A cg21577049 chr2:228736449 WDR69 -0.47 -6.22 -0.32 1.5e-9 Blood pressure; CRC cis rs7927771 0.864 rs112060627 chr11:47426956 G/A cg05585544 chr11:47624801 NA -0.55 -9.79 -0.47 5.02e-20 Subjective well-being; CRC cis rs208520 0.690 rs12189780 chr6:66759619 G/A cg07460842 chr6:66804631 NA 1.06 14.68 0.63 7.14e-38 Exhaled nitric oxide output; CRC cis rs7618915 0.501 rs7611731 chr3:52692721 T/C cg10802521 chr3:52805072 NEK4 -0.56 -8.89 -0.44 4.12e-17 Bipolar disorder; CRC cis rs11625487 0.609 rs45493395 chr14:77976468 T/C cg06469542 chr14:77965869 ISM2 -0.47 -5.61 -0.3 4.4e-8 Neutrophil percentage of white cells;Sum neutrophil eosinophil counts;Neutrophil count; CRC cis rs597539 0.617 rs672853 chr11:68636362 G/A cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.86 13.76 0.6 2.37e-34 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs9906695 0.846 rs4795902 chr17:32618701 T/C cg12698626 chr17:32581466 CCL2 0.48 6.4 0.33 5.32e-10 Monocyte percentage of white cells; CRC cis rs763121 0.853 rs1569492 chr22:38975511 A/G cg06022373 chr22:39101656 GTPBP1 -0.72 -11.57 -0.54 3.3e-26 Menopause (age at onset); CRC cis rs9400271 0.632 rs34981677 chr6:109590920 T/C cg01475377 chr6:109611718 NA -0.35 -6.07 -0.32 3.56e-9 Sum neutrophil eosinophil counts;Sum basophil neutrophil counts;White blood cell count;Neutrophil count;Myeloid white cell count;Granulocyte count; CRC cis rs763121 0.853 rs6001191 chr22:39074452 T/C cg06022373 chr22:39101656 GTPBP1 0.8 12.62 0.57 4.84e-30 Menopause (age at onset); CRC trans rs11148252 0.740 rs9536052 chr13:52960709 C/G cg18335740 chr13:41363409 SLC25A15 -0.47 -7.12 -0.37 6.8e-12 Lewy body disease; CRC cis rs17818399 0.547 rs4953400 chr2:46777208 T/A cg26688816 chr2:46740690 ATP6V1E2 -0.44 -5.8 -0.3 1.59e-8 Height; CRC cis rs7481584 0.624 rs436580 chr11:3063961 T/G cg25174290 chr11:3078921 CARS -0.45 -6.22 -0.32 1.5e-9 Calcium levels; CRC cis rs9296092 0.517 rs3912041 chr6:33521271 T/C cg13560919 chr6:33536144 NA -0.43 -6.17 -0.32 2.04e-9 Age at smoking initiation in chronic obstructive pulmonary disease; CRC cis rs12431939 1.000 rs60593258 chr14:51662280 T/A cg23942311 chr14:51606299 NA -0.52 -6.25 -0.33 1.25e-9 Cancer; CRC cis rs2180341 1.000 rs2180341 chr6:127600630 C/T cg27446573 chr6:127587934 RNF146 0.99 14.72 0.63 4.87e-38 Breast cancer; CRC cis rs561341 1.000 rs530715 chr17:30320544 T/G cg19193384 chr17:30244184 NA -0.53 -6.73 -0.35 7.6e-11 Hip circumference adjusted for BMI; CRC cis rs2404602 0.647 rs12898416 chr15:77042292 C/G cg23625390 chr15:77176239 SCAPER -0.84 -12.98 -0.58 2.2e-31 Blood metabolite levels; CRC cis rs9325144 0.600 rs10785621 chr12:38744912 C/T cg13010199 chr12:38710504 ALG10B 0.39 5.83 0.31 1.31e-8 Morning vs. evening chronotype; CRC cis rs12024301 0.557 rs10911408 chr1:183660803 A/G cg11505048 chr1:183622726 RGL1;APOBEC4 0.71 6.24 0.33 1.33e-9 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs7605827 0.897 rs11674618 chr2:15593035 T/C cg19274914 chr2:15703543 NA 0.39 5.9 0.31 9.14e-9 Educational attainment (years of education); CRC trans rs492478 0.892 rs77364866 chr5:3926042 C/T cg09199442 chr11:28132951 METT5D1 -0.7 -6.18 -0.32 1.95e-9 Cognitive performance; CRC cis rs12476592 0.516 rs6546002 chr2:63593829 A/C cg10828910 chr2:63850056 LOC388955 0.46 5.61 0.3 4.31e-8 Childhood ear infection; CRC cis rs12477438 0.798 rs1349778 chr2:99645011 G/C cg14399236 chr2:99771627 LIPT1;TSGA10 -0.71 -9.93 -0.48 1.71e-20 Chronic sinus infection; CRC cis rs9467711 0.659 rs13195509 chr6:26463660 C/T cg12315302 chr6:26189340 HIST1H4D 0.96 6.61 0.34 1.58e-10 Autism spectrum disorder or schizophrenia; CRC trans rs116095464 0.510 rs10057501 chr5:239545 T/C cg00938859 chr5:1591904 SDHAP3 0.74 7.83 0.4 6.6e-14 Breast cancer; CRC cis rs2404602 0.692 rs8024476 chr15:76983954 T/C cg22467129 chr15:76604101 ETFA -0.4 -6.67 -0.35 1.09e-10 Blood metabolite levels; CRC cis rs2996428 0.667 rs111640545 chr1:3752792 G/A cg13057898 chr1:3703894 LRRC47 0.54 7.11 0.37 7.06e-12 Red cell distribution width; CRC cis rs6547741 0.904 rs2384659 chr2:27856793 G/A cg27432699 chr2:27873401 GPN1 0.73 13.08 0.58 8.86e-32 Oral cavity cancer; CRC trans rs61931739 0.500 rs11524949 chr12:34435551 C/T cg26384229 chr12:38710491 ALG10B 0.66 8.74 0.43 1.18e-16 Morning vs. evening chronotype; CRC cis rs75920871 0.528 rs10466590 chr11:116894413 C/G cg01368799 chr11:117014884 PAFAH1B2 -0.41 -5.9 -0.31 8.89e-9 Subjective well-being; CRC cis rs1524976 1.000 rs1917531 chr3:65503221 A/G cg16238336 chr3:65465873 MAGI1 0.45 5.94 0.31 7.44e-9 PR interval; CRC cis rs7927592 0.731 rs11228288 chr11:68353550 A/G cg01657329 chr11:68192670 LRP5 -0.57 -9.43 -0.46 7.8e-19 Total body bone mineral density; CRC trans rs916888 0.779 rs199528 chr17:44843136 C/T cg07870213 chr5:140052090 DND1 1.04 11.25 0.53 4.81e-25 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs763014 0.966 rs15564 chr16:677854 G/T cg07343612 chr16:622815 PIGQ -0.76 -12.86 -0.58 6.21e-31 Height; CRC cis rs3733585 0.638 rs28715627 chr4:9958140 T/A cg00071950 chr4:10020882 SLC2A9 -0.54 -9.58 -0.47 2.54e-19 Cleft plate (environmental tobacco smoke interaction); CRC cis rs2735413 0.918 rs4309408 chr16:78071507 G/A cg04733911 chr16:78082701 NA -0.42 -6.97 -0.36 1.72e-11 Systolic blood pressure (alcohol consumption interaction); CRC cis rs4684776 0.676 rs2067472 chr3:11299190 G/C cg00170343 chr3:11313890 ATG7 -0.5 -5.87 -0.31 1.04e-8 Small vessel stroke; CRC cis rs9469578 1.000 rs73743336 chr6:33715391 G/A cg18708504 chr6:33715942 IP6K3 0.66 7.56 0.38 4e-13 Phosphorus levels; CRC cis rs6951245 0.935 rs76525951 chr7:1096013 C/T cg26224354 chr7:1096374 C7orf50;GPR146 -0.93 -12.11 -0.56 3.59e-28 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs2949837 0.603 rs1542818 chr7:45977656 G/T cg06713098 chr7:45960367 IGFBP3 0.42 6.71 0.35 8.43e-11 Sitting height ratio; CRC cis rs10504229 0.817 rs78138632 chr8:58191341 G/T cg21724239 chr8:58056113 NA 0.75 8.8 0.44 8.08e-17 Developmental language disorder (linguistic errors); CRC cis rs34172651 0.517 rs8059004 chr16:24837905 G/A cg04756594 chr16:24857601 SLC5A11 0.3 6.24 0.33 1.36e-9 Intelligence (multi-trait analysis); CRC trans rs1005277 0.540 rs2474598 chr10:38430296 C/T cg11292332 chr7:45801988 SEPT13 0.36 6.24 0.33 1.37e-9 Extrinsic epigenetic age acceleration; CRC cis rs1448094 0.556 rs11614513 chr12:86167756 G/C cg00310523 chr12:86230176 RASSF9 0.4 6.52 0.34 2.6200000000000003e-10 Major depressive disorder; CRC cis rs6546324 0.559 rs4671806 chr2:67777158 C/G cg15745817 chr2:67799979 NA -0.53 -8.68 -0.43 1.84e-16 Endometriosis; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg11940773 chr11:63606512 MARK2 0.45 6.31 0.33 8.82e-10 Anxiety disorder; CRC cis rs2786111 0.965 rs1764791 chr1:197281954 T/A cg13682187 chr1:196946512 CFHR5 0.29 5.69 0.3 2.87e-8 Lupus nephritis in systemic lupus erythematosus; CRC cis rs1387259 0.859 rs2054905 chr12:48687951 A/G cg04545296 chr12:48745243 ZNF641 0.33 5.66 0.3 3.26e-8 Obstructive sleep apnea trait (apnea hypopnea index); CRC cis rs2404602 0.716 rs8030411 chr15:76699855 A/G cg23625390 chr15:77176239 SCAPER 0.47 6.85 0.35 3.71e-11 Blood metabolite levels; CRC cis rs9457247 1.000 rs1794693 chr6:167405670 T/C cg23791538 chr6:167370224 RNASET2 -0.38 -5.94 -0.31 7.32e-9 Crohn's disease; CRC cis rs9372498 0.536 rs9489457 chr6:118920285 C/T cg22561889 chr6:118971681 C6orf204 0.5 6.39 0.33 5.8e-10 Diastolic blood pressure; CRC cis rs780096 0.526 rs704791 chr2:27657167 T/C cg02592271 chr2:27665507 KRTCAP3 -0.29 -6.69 -0.35 9.47e-11 Total body bone mineral density; CRC cis rs6963495 0.818 rs6943132 chr7:105166776 C/T cg02135003 chr7:105160482 PUS7 -0.95 -11.72 -0.54 9.39e-27 Bipolar disorder (body mass index interaction); CRC cis rs10946940 0.965 rs6915266 chr6:27528643 G/A cg06470822 chr6:28175283 NA -0.52 -7.21 -0.37 3.95e-12 Systemic lupus erythematosus; CRC cis rs11122272 0.735 rs2808600 chr1:231534723 T/C cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.58 -8.61 -0.43 2.98e-16 Hemoglobin concentration; CRC cis rs262150 0.819 rs6956589 chr7:158769301 C/T cg19418458 chr7:158789849 NA -0.44 -7.51 -0.38 5.49e-13 Facial morphology (factor 20); CRC cis rs72781680 0.898 rs17462433 chr2:24012758 T/C cg08917208 chr2:24149416 ATAD2B 0.84 8.11 0.41 1e-14 Lymphocyte counts; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg11883161 chr10:99894664 C10orf28 0.47 6.45 0.34 3.95e-10 Anxiety disorder; CRC trans rs11098499 0.863 rs9997631 chr4:120469995 C/G cg25214090 chr10:38739885 LOC399744 0.65 10.5 0.5 2.02e-22 Corneal astigmatism; CRC cis rs35110281 0.811 rs4819264 chr21:45017349 G/T cg01579765 chr21:45077557 HSF2BP -0.39 -7.57 -0.39 3.82e-13 Mean corpuscular volume; CRC cis rs35520189 0.591 rs12105482 chr2:113697235 G/T cg12858261 chr2:113808755 IL1F8 0.43 5.91 0.31 8.69e-9 Obstructive sleep apnea trait (apnea hypopnea index); CRC cis rs9467773 0.620 rs2130657 chr6:26650826 C/T cg09904177 chr6:26538194 HMGN4 0.72 11.39 0.53 1.47e-25 Intelligence (multi-trait analysis); CRC trans rs925098 0.577 rs2724470 chr4:17996046 A/G cg24201716 chr10:115933917 C10orf118;MIR2110 -0.42 -6.15 -0.32 2.19e-9 Birth weight;Height; CRC cis rs7949030 0.626 rs7930896 chr11:62325272 A/G cg11742103 chr11:62369870 EML3;MTA2 0.6 11.56 0.54 3.46e-26 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; CRC cis rs10479542 0.766 rs7733389 chr5:178974997 C/T cg09060608 chr5:178986726 RUFY1 0.42 6.96 0.36 1.83e-11 Lung cancer; CRC cis rs7666738 1.000 rs880473 chr4:98922596 C/T cg03676636 chr4:99064102 C4orf37 0.24 6.64 0.34 1.28e-10 Colonoscopy-negative controls vs population controls; CRC cis rs16852403 0.548 rs316269 chr1:178107862 C/G cg00404053 chr1:178313656 RASAL2 -0.5 -6.65 -0.34 1.22e-10 Childhood ear infection; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg10550416 chr2:36776323 CRIM1 0.38 5.98 0.31 5.75e-9 Liver disease severity in Alagille syndrome; CRC cis rs2180341 0.814 rs6905553 chr6:127727407 A/G cg24812749 chr6:127587940 RNF146 0.67 9.02 0.45 1.59e-17 Breast cancer; CRC cis rs12431939 0.546 rs4424815 chr14:51714360 C/A cg23942311 chr14:51606299 NA 0.47 6.14 0.32 2.41e-9 Cancer; CRC cis rs941873 0.900 rs7092536 chr10:81131332 A/C cg09469691 chr10:81107165 PPIF 0.51 8.02 0.4 1.82e-14 Height; CRC cis rs1223397 0.651 rs402705 chr6:13296439 C/T cg07912922 chr6:13274314 PHACTR1 0.36 5.62 0.3 4.18e-8 Blood pressure; CRC cis rs1256061 0.646 rs1256059 chr14:64710417 A/G cg23250157 chr14:64679961 SYNE2 0.43 6.84 0.35 3.95e-11 Hemoglobin concentration;Red blood cell count;Hematocrit; CRC cis rs7618915 0.547 rs11714419 chr3:52628816 A/G cg18404041 chr3:52824283 ITIH1 -0.44 -8.95 -0.44 2.73e-17 Bipolar disorder; CRC cis rs853679 0.517 rs9295758 chr6:28120663 C/G cg03623178 chr6:28175578 NA 0.98 12.66 0.57 3.31e-30 Depression; CRC cis rs2072499 0.554 rs1052067 chr1:156206121 C/T cg24450063 chr1:156163899 SLC25A44 0.83 11.41 0.53 1.29e-25 Testicular germ cell tumor; CRC trans rs12432203 1.000 rs3935982 chr14:51730252 T/A cg14592830 chr9:122318704 NA 0.59 6.12 0.32 2.62e-9 Cancer; CRC cis rs4601821 0.823 rs4938013 chr11:113264470 A/C cg14159747 chr11:113255604 NA 0.52 9.66 0.47 1.36e-19 Alcoholic chronic pancreatitis; CRC cis rs6088590 0.813 rs1884668 chr20:33285514 A/G cg08999081 chr20:33150536 PIGU 0.57 10.46 0.5 2.76e-22 Coronary artery disease; CRC cis rs2976388 0.566 rs6998746 chr8:143802456 A/C cg12516270 chr8:143859308 LYNX1 0.42 6.92 0.36 2.42e-11 Urinary tract infection frequency; CRC cis rs9435341 0.965 rs1762482 chr1:107599002 A/C cg11070056 chr1:107600091 PRMT6 -0.4 -5.99 -0.31 5.5e-9 Facial morphology (factor 21, depth of nasal alae); CRC cis rs3749237 0.595 rs885592 chr3:49497883 T/G cg03060546 chr3:49711283 APEH 0.69 11.95 0.55 1.36e-27 Resting heart rate; CRC cis rs2346177 0.542 rs6718875 chr2:46687982 G/T cg02822958 chr2:46747628 ATP6V1E2 0.41 5.86 0.31 1.15e-8 HDL cholesterol; CRC cis rs2839186 0.732 rs8131458 chr21:47694712 G/A cg02776659 chr21:47717406 C21orf57 -0.35 -5.73 -0.3 2.33e-8 Testicular germ cell tumor; CRC cis rs6662572 0.703 rs10789482 chr1:46396704 G/A cg03123370 chr1:45965343 CCDC163P;MMACHC -0.45 -5.76 -0.3 1.98e-8 Blood protein levels; CRC cis rs501916 0.605 rs11070612 chr15:48073174 C/G cg16110827 chr15:48056943 SEMA6D -0.46 -6.63 -0.34 1.4e-10 Inflammatory bowel disease;Ulcerative colitis; CRC cis rs6762 0.748 rs28735718 chr11:839629 A/G cg16425592 chr11:842748 TSPAN4;POLR2L -0.56 -8.23 -0.41 4.32e-15 Mean platelet volume; CRC cis rs801193 1.000 rs3778909 chr7:66255646 G/C cg18876405 chr7:65276391 NA 0.59 10.55 0.5 1.34e-22 Aortic root size; CRC cis rs7662987 0.517 rs2602872 chr4:100038996 A/G cg13256891 chr4:100009986 ADH5 0.63 8.57 0.43 3.99e-16 Smoking initiation; CRC cis rs9341808 0.558 rs2490234 chr6:80816966 G/C cg08355045 chr6:80787529 NA 0.38 6.32 0.33 8.44e-10 Sitting height ratio; CRC cis rs1348850 0.645 rs11889272 chr2:178432378 C/T cg27490568 chr2:178487706 NA 0.53 6.5 0.34 2.96e-10 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs2404602 0.647 rs10851892 chr15:77176491 T/C cg23625390 chr15:77176239 SCAPER -0.86 -12.75 -0.58 1.57e-30 Blood metabolite levels; CRC cis rs897984 0.721 rs2305884 chr16:30970741 G/A cg02466173 chr16:30829666 NA 0.62 9.3 0.46 1.96e-18 Dementia with Lewy bodies; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg04231340 chr16:50501845 NA 0.36 6.07 0.32 3.44e-9 Response to antipsychotic treatment; CRC cis rs7909074 0.531 rs879344 chr10:45400667 G/C cg05187965 chr10:45406764 TMEM72 -0.34 -6.71 -0.35 8.49e-11 Mean corpuscular volume; CRC cis rs12368653 0.789 rs17852479 chr12:58126234 C/A cg00677455 chr12:58241039 CTDSP2 -0.51 -6.93 -0.36 2.29e-11 Multiple sclerosis; CRC cis rs317689 0.819 rs317677 chr12:69691806 G/A cg20891283 chr12:69753455 YEATS4 0.46 6.06 0.32 3.65e-9 Response to diuretic therapy; CRC cis rs11229555 0.874 rs11605683 chr11:58350794 T/A cg15696309 chr11:58395628 NA -0.95 -12.73 -0.57 1.82e-30 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; CRC trans rs7618501 1.000 rs60205400 chr3:49800272 C/T cg21659725 chr3:3221576 CRBN 0.91 17.27 0.69 4.82e-48 Intelligence (multi-trait analysis); CRC cis rs17376456 0.825 rs55947981 chr5:93278104 G/T cg21475434 chr5:93447410 FAM172A 0.82 7.84 0.4 6.37e-14 Diabetic retinopathy; CRC cis rs11190604 0.790 rs11190535 chr10:102197441 A/T cg16342193 chr10:102329863 NA -0.35 -5.85 -0.31 1.18e-8 Palmitoleic acid (16:1n-7) levels; CRC cis rs910187 0.678 rs3818014 chr20:45816649 C/T cg27589058 chr20:45804311 EYA2 -0.39 -7.51 -0.38 5.6e-13 Migraine; CRC cis rs3796352 0.667 rs11720228 chr3:52877270 G/A cg07884673 chr3:53033167 SFMBT1 0.75 6.1 0.32 3.02e-9 Immune reponse to smallpox (secreted IL-2); CRC cis rs6121246 0.567 rs6060295 chr20:30198473 C/T cg18721089 chr20:30220636 NA -0.53 -7.98 -0.4 2.43e-14 Mean corpuscular hemoglobin; CRC cis rs3796352 0.527 rs11715498 chr3:52943551 G/C cg06204229 chr3:52865917 ITIH4 0.43 5.95 0.31 6.94e-9 Immune reponse to smallpox (secreted IL-2); CRC cis rs7945718 0.621 rs10831891 chr11:12676140 A/G cg25843174 chr11:12811716 TEAD1 0.39 7.07 0.36 9.43e-12 Educational attainment (years of education); CRC trans rs7267979 0.934 rs2261753 chr20:25262291 G/A cg17903999 chr18:56338584 MALT1 -0.41 -6.88 -0.35 2.97e-11 Liver enzyme levels (alkaline phosphatase); CRC cis rs11098499 0.909 rs79704848 chr4:120309351 T/A cg09307838 chr4:120376055 NA 0.71 10.93 0.52 6.41e-24 Corneal astigmatism; CRC cis rs7618915 0.547 rs4130905 chr3:52709831 A/T cg15147215 chr3:52552868 STAB1 -0.62 -10.31 -0.49 8.76e-22 Bipolar disorder; CRC cis rs7178572 1.000 rs952472 chr15:77776562 A/C cg22256960 chr15:77711686 NA -0.7 -10.77 -0.51 2.3e-23 Type 2 diabetes; CRC cis rs3820068 0.603 rs59475085 chr1:15911131 G/A cg13390004 chr1:15929781 NA 0.43 5.7 0.3 2.6e-8 Systolic blood pressure; CRC cis rs11628318 0.515 rs8009257 chr14:103155594 A/G cg12046867 chr14:103022105 NA 0.44 6.0 0.31 5.2e-9 Platelet count; CRC cis rs262150 0.731 rs2657388 chr7:158763428 A/G cg12590608 chr7:158785262 NA -0.43 -7.8 -0.4 8.03e-14 Facial morphology (factor 20); CRC cis rs763121 0.853 rs5757196 chr22:39039855 G/C cg06022373 chr22:39101656 GTPBP1 0.78 12.39 0.56 3.54e-29 Menopause (age at onset); CRC cis rs644799 0.710 rs564480 chr11:95561741 C/T cg03916912 chr11:95522834 CEP57;FAM76B 0.85 15.96 0.66 7.1e-43 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs11229555 0.645 rs11229445 chr11:58199458 G/A cg15696309 chr11:58395628 NA -0.83 -10.89 -0.51 8.82e-24 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; CRC cis rs9372498 0.536 rs62421539 chr6:118730559 C/A cg01339444 chr6:118972232 C6orf204 0.52 5.82 0.31 1.41e-8 Diastolic blood pressure; CRC cis rs2153535 0.580 rs9393016 chr6:8458573 T/A cg07606381 chr6:8435919 SLC35B3 0.69 11.15 0.52 1.04e-24 Motion sickness; CRC cis rs9910055 0.762 rs2526021 chr17:42213347 G/A cg13607699 chr17:42295918 UBTF 0.49 6.77 0.35 5.99e-11 Total body bone mineral density; CRC trans rs11039798 1.000 rs7123704 chr11:48580535 G/A cg03929089 chr4:120376271 NA 0.62 6.13 0.32 2.56e-9 Axial length; CRC cis rs2842992 0.768 rs2273824 chr6:160211445 C/T cg16489826 chr6:160211363 TCP1;MRPL18 0.61 9.01 0.44 1.69e-17 Age-related macular degeneration (geographic atrophy); CRC cis rs853679 0.517 rs4713152 chr6:28137454 G/A cg02631126 chr6:28058918 ZSCAN12L1 0.29 5.91 0.31 8.38e-9 Depression; CRC cis rs10883723 0.810 rs2296589 chr10:104248106 T/A cg22532475 chr10:104410764 TRIM8 -0.37 -6.85 -0.35 3.57e-11 Allergic disease (asthma, hay fever or eczema); CRC cis rs2952156 0.920 rs9675194 chr17:37833805 A/G cg20243544 chr17:37824526 PNMT 0.56 8.87 0.44 4.65e-17 Asthma; CRC trans rs2228479 1.000 rs62052186 chr16:89969567 A/T cg24644049 chr4:85504048 CDS1 0.9 7.92 0.4 3.58e-14 Skin colour saturation; CRC cis rs875971 0.545 rs316306 chr7:65618674 G/A cg02869306 chr7:64672164 INTS4L1 0.44 6.31 0.33 8.91e-10 Aortic root size; CRC trans rs587242 1.000 rs2985639 chr1:96894735 C/T cg10631902 chr5:14652156 NA 0.44 6.83 0.35 4.21e-11 Body mass index (joint analysis main effects and physical activity interaction);Body mass index in physically inactive individuals;Body mass index; CRC cis rs950776 0.506 rs12915366 chr15:78831753 G/A cg06917634 chr15:78832804 PSMA4 0.66 10.49 0.5 2.16e-22 Sudden cardiac arrest; CRC cis rs2836974 0.568 rs428602 chr21:40547004 A/G cg17971929 chr21:40555470 PSMG1 0.7 10.58 0.5 1.02e-22 Cognitive function; CRC cis rs1707322 0.752 rs12024590 chr1:46127496 A/C cg06784218 chr1:46089804 CCDC17 0.65 12.18 0.56 2e-28 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs6582630 0.519 rs8186992 chr12:38325848 C/T cg13010199 chr12:38710504 ALG10B 0.46 6.3 0.33 9.4e-10 Drug-induced liver injury (flucloxacillin); CRC trans rs7757969 0.500 rs9487731 chr6:112154848 T/C cg08211895 chr2:48828358 STON1-GTF2A1L 0.31 6.04 0.32 4.14e-9 Schizophrenia; CRC trans rs11722228 0.522 rs12503195 chr4:10082772 T/C cg26043149 chr18:55253948 FECH 0.91 14.41 0.62 8.15e-37 Gout;Urate levels;Serum uric acid levels; CRC cis rs7089973 0.872 rs10490908 chr10:116616162 T/C cg03647239 chr10:116582469 FAM160B1 0.41 5.75 0.3 2.01e-8 Bipolar disorder or attention deficit hyperactivity disorder; CRC cis rs13108904 0.935 rs13148614 chr4:1248357 G/C cg23123621 chr4:1343375 KIAA1530 0.36 6.36 0.33 6.62e-10 Obesity-related traits; CRC cis rs7584330 0.554 rs74001399 chr2:238445440 G/A cg14458575 chr2:238380390 NA 0.52 7.24 0.37 3.16e-12 Prostate cancer; CRC cis rs72615157 0.561 rs113844570 chr7:99873778 A/C cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.6 6.75 0.35 6.8e-11 Lung function (FEV1/FVC); CRC cis rs6089584 0.850 rs6089634 chr20:60632566 T/C cg18761221 chr20:60518478 NA 0.48 7.84 0.4 6.23e-14 Body mass index; CRC cis rs2408955 0.522 rs7139330 chr12:48483484 A/C cg21466736 chr12:48725269 NA 0.46 7.12 0.37 6.99e-12 Glycated hemoglobin levels; CRC cis rs8114671 0.562 rs6087641 chr20:33467717 T/C cg07148914 chr20:33460835 GGT7 0.37 6.29 0.33 1.02e-9 Height; CRC cis rs10504229 0.775 rs17805146 chr8:58161484 G/A cg08219700 chr8:58056026 NA 0.46 5.61 0.3 4.24e-8 Developmental language disorder (linguistic errors); CRC cis rs6912958 0.667 rs7746545 chr6:88090225 A/G cg12350822 chr6:88032061 C6orf162;GJB7 0.47 9.39 0.46 9.96e-19 Monocyte percentage of white cells; CRC cis rs4494114 0.967 rs1925677 chr1:39346905 T/G cg25970120 chr1:39325951 RRAGC -0.46 -6.38 -0.33 5.88e-10 Blood protein levels; CRC cis rs6973256 0.897 rs7780456 chr7:133328782 C/T cg10665199 chr7:133106180 EXOC4 -0.37 -5.69 -0.3 2.77e-8 Intelligence (multi-trait analysis); CRC cis rs727479 0.502 rs2304463 chr15:51508120 A/C cg19946085 chr15:51559439 CYP19A1 -0.3 -6.03 -0.32 4.47e-9 Estradiol levels; CRC cis rs11758351 0.660 rs56398712 chr6:26213868 A/G cg10723962 chr6:26240782 HIST1H4F -0.38 -6.12 -0.32 2.66e-9 Gout;Renal underexcretion gout; CRC cis rs9400271 0.632 rs6930698 chr6:109590304 A/G cg01475377 chr6:109611718 NA -0.35 -6.07 -0.32 3.56e-9 Sum neutrophil eosinophil counts;Sum basophil neutrophil counts;White blood cell count;Neutrophil count;Myeloid white cell count;Granulocyte count; CRC cis rs7191700 0.511 rs243330 chr16:11350991 C/T cg00044050 chr16:11439710 C16orf75 0.51 7.32 0.37 1.92e-12 Multiple sclerosis; CRC cis rs9341808 0.650 rs6909546 chr6:80869923 C/G cg08355045 chr6:80787529 NA 0.42 6.92 0.36 2.41e-11 Sitting height ratio; CRC cis rs4713118 0.955 rs9468200 chr6:27683063 T/A cg25164649 chr6:28176230 NA 0.56 7.44 0.38 9.1e-13 Parkinson's disease; CRC cis rs1448094 0.556 rs4897831 chr12:86168248 C/T cg06740227 chr12:86229804 RASSF9 0.37 5.62 0.3 4.02e-8 Major depressive disorder; CRC trans rs11098499 0.909 rs28581362 chr4:120283548 T/A cg25214090 chr10:38739885 LOC399744 0.61 9.66 0.47 1.39e-19 Corneal astigmatism; CRC cis rs7772486 0.754 rs9373475 chr6:146126419 C/T cg23711669 chr6:146136114 FBXO30 0.78 13.57 0.6 1.27e-33 Lobe attachment (rater-scored or self-reported); CRC cis rs6502050 0.787 rs8080682 chr17:80058901 G/A cg02741985 chr17:80059408 CCDC57 -0.46 -7.46 -0.38 7.96e-13 Life satisfaction; CRC cis rs7927771 0.832 rs4992357 chr11:47393638 C/T cg20307385 chr11:47447363 PSMC3 -0.63 -9.3 -0.46 2e-18 Subjective well-being; CRC cis rs2072510 0.569 rs7134860 chr12:96390358 C/A cg15438951 chr12:96389694 HAL -0.49 -5.92 -0.31 7.95e-9 Metabolite levels (small molecules and protein measures); CRC cis rs9611565 0.512 rs4820446 chr22:42215684 C/T cg06634786 chr22:41940651 POLR3H -0.72 -7.81 -0.4 7.92e-14 Vitiligo; CRC cis rs3857067 0.806 rs7678054 chr4:95093855 A/G cg11021082 chr4:95130006 SMARCAD1 0.46 7.01 0.36 1.35e-11 QT interval; CRC cis rs2346177 0.542 rs13020043 chr2:46698431 A/T cg02822958 chr2:46747628 ATP6V1E2 0.41 5.8 0.3 1.54e-8 HDL cholesterol; CRC cis rs9811920 0.609 rs4244713 chr3:99679584 T/G cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G -0.46 -6.19 -0.32 1.79e-9 Axial length; CRC cis rs1570989 0.841 rs9349054 chr6:12029312 C/T cg17804551 chr6:12015979 HIVEP1 -0.38 -5.71 -0.3 2.46e-8 Alcohol and nicotine co-dependence; CRC cis rs9443645 0.870 rs9350799 chr6:79723651 C/A cg09184832 chr6:79620586 NA -0.48 -8.55 -0.43 4.82e-16 Intelligence (multi-trait analysis); CRC cis rs7647973 1.000 rs6446262 chr3:49401153 T/C cg20833759 chr3:49053208 WDR6;DALRD3 0.62 9.27 0.46 2.46e-18 Menarche (age at onset); CRC cis rs6681460 0.625 rs6679568 chr1:67074177 C/T cg02459107 chr1:67143332 SGIP1 0.32 5.76 0.3 1.93e-8 Presence of antiphospholipid antibodies; CRC trans rs11343 0.675 rs7359333 chr16:19262344 A/T cg11644585 chr17:8958019 NTN1 -0.43 -6.21 -0.32 1.62e-9 Parkinson's disease; CRC cis rs10479542 0.784 rs7702303 chr5:178986436 G/A cg22764044 chr5:178986830 RUFY1 0.42 7.16 0.37 5.43e-12 Lung cancer; CRC cis rs9837602 0.935 rs9875640 chr3:99729091 C/T cg07805332 chr3:99536008 MIR548G;C3orf26 -0.49 -6.53 -0.34 2.52e-10 Breast cancer; CRC cis rs13392177 0.684 rs6720449 chr2:219080978 G/A cg04880052 chr2:219191631 PNKD -0.41 -6.17 -0.32 2.03e-9 Pyoderma gangrenosum in inflammatory bowel disease; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg23290343 chr5:107717310 FBXL17 0.4 6.29 0.33 1.01e-9 Liver disease severity in Alagille syndrome; CRC cis rs736408 0.509 rs2590838 chr3:52622086 G/A cg08222913 chr3:52553049 STAB1 -0.39 -7.6 -0.39 3.17e-13 Bipolar disorder; CRC trans rs453301 0.522 rs2929309 chr8:9083771 C/A cg16141378 chr3:129829833 LOC729375 0.41 6.19 0.32 1.78e-9 Joint mobility (Beighton score); CRC cis rs977987 0.836 rs35209155 chr16:75470496 G/A cg03315344 chr16:75512273 CHST6 0.56 9.58 0.47 2.43e-19 Dupuytren's disease; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg21558545 chr12:71834859 LGR5 0.49 6.76 0.35 6.13e-11 Thyroid stimulating hormone; CRC cis rs11690935 0.686 rs10165126 chr2:172820315 C/T cg13550731 chr2:172543902 DYNC1I2 -0.85 -13.0 -0.58 1.81e-31 Schizophrenia; CRC cis rs9326248 1.000 rs4938344 chr11:117003749 G/A cg15534755 chr11:117069859 TAGLN 0.33 6.01 0.31 4.96e-9 Blood protein levels; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg05358025 chr19:4868071 PLIN3 0.46 6.05 0.32 3.9e-9 Thyroid stimulating hormone; CRC cis rs2692947 0.644 rs3821051 chr2:96912787 A/G cg23100626 chr2:96804247 ASTL -0.27 -6.87 -0.35 3.21e-11 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; CRC cis rs16867335 0.947 rs16867341 chr2:181488938 C/G cg23363182 chr2:181467187 NA -0.48 -6.47 -0.34 3.56e-10 Survival in rectal cancer; CRC cis rs1348850 0.914 rs7573763 chr2:178249808 C/T cg22681709 chr2:178499509 PDE11A -0.37 -6.85 -0.35 3.73e-11 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs12024301 0.557 rs12041999 chr1:183608393 T/G cg11505048 chr1:183622726 RGL1;APOBEC4 0.77 6.73 0.35 7.45e-11 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs1178968 1.000 rs4717755 chr7:72761178 T/G cg25889504 chr7:72793014 NA 0.49 5.83 0.31 1.32e-8 Triglyceride levels; CRC cis rs875971 0.862 rs11765791 chr7:65936574 A/G cg18252515 chr7:66147081 NA -0.41 -5.74 -0.3 2.14e-8 Aortic root size; CRC cis rs3785574 0.638 rs2854182 chr17:61969062 G/A cg23090583 chr17:61904693 PSMC5;FTSJ3 0.62 8.68 0.43 1.87e-16 Height; CRC cis rs9323205 0.677 rs11620820 chr14:51734445 C/T cg23942311 chr14:51606299 NA -0.5 -5.8 -0.3 1.53e-8 Cancer; CRC cis rs765787 0.530 rs12909987 chr15:45512207 C/T cg24006582 chr15:45444508 DUOX1 -0.5 -7.6 -0.39 3.09e-13 Uric acid levels; CRC cis rs12135062 0.755 rs1553287 chr1:3101277 G/A cg21609526 chr1:3105151 PRDM16 -0.57 -9.63 -0.47 1.69e-19 Migraine; CRC cis rs7208859 0.623 rs55724095 chr17:29153058 A/G cg13385521 chr17:29058706 SUZ12P 0.64 7.34 0.38 1.63e-12 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs9354308 0.933 rs12203567 chr6:66589062 T/C cg07460842 chr6:66804631 NA 0.46 5.8 0.3 1.55e-8 Metabolite levels; CRC cis rs447921 0.953 rs16968964 chr17:74455272 C/T cg20706315 chr17:74366578 NA 0.5 6.67 0.35 1.09e-10 Mitochondrial DNA levels; CRC cis rs17376456 0.877 rs35747258 chr5:93310129 C/T cg25358565 chr5:93447407 FAM172A 1.06 10.59 0.5 9.22e-23 Diabetic retinopathy; CRC trans rs11165623 0.585 rs55896436 chr1:96994162 G/A cg10631902 chr5:14652156 NA -0.4 -6.97 -0.36 1.79e-11 Hip circumference;Waist circumference; CRC cis rs9522267 0.535 rs6492373 chr13:112238627 T/C cg26182253 chr13:112236782 NA -0.31 -6.24 -0.33 1.35e-9 Hepatitis; CRC cis rs11958404 0.932 rs72818113 chr5:157439825 G/T cg05962755 chr5:157440814 NA 1.01 12.88 0.58 5.12e-31 IgG glycosylation; CRC cis rs7474896 0.559 rs1208779 chr10:38077729 A/C cg25427524 chr10:38739819 LOC399744 -0.64 -7.77 -0.39 1.04e-13 Obesity (extreme); CRC cis rs514406 0.861 rs1412706 chr1:53237721 G/A cg27535305 chr1:53392650 SCP2 0.39 7.07 0.36 9.17e-12 Monocyte count; CRC cis rs6701037 0.512 rs2285216 chr1:175133012 C/T cg17845761 chr1:175162550 KIAA0040 0.3 6.41 0.33 5.02e-10 Alcohol dependence; CRC cis rs875971 0.830 rs28714531 chr7:65968237 G/A cg11764359 chr7:65958608 NA 0.58 8.69 0.43 1.8e-16 Aortic root size; CRC cis rs2032447 0.966 rs3752416 chr6:26045929 T/C cg04800585 chr6:26043546 HIST1H2BB 0.54 8.33 0.42 2.27e-15 Intelligence (multi-trait analysis); CRC cis rs2115630 1.000 rs58581703 chr15:85276935 C/T cg11189052 chr15:85197271 WDR73 -0.6 -9.78 -0.47 5.25e-20 P wave terminal force; CRC trans rs2303319 0.504 rs12473497 chr2:162433766 T/C cg10498984 chr16:28874827 SH2B1 -0.73 -5.99 -0.31 5.54e-9 Cognitive function; CRC cis rs11711311 0.911 rs3773681 chr3:113523901 C/T cg15478005 chr3:113465772 ATP6V1A;NAA50 0.43 5.9 0.31 8.95e-9 IgG glycosylation; CRC cis rs6546550 0.901 rs6750488 chr2:70146125 C/T cg02498382 chr2:70120550 SNRNP27 -0.56 -9.52 -0.46 3.78e-19 Prevalent atrial fibrillation; CRC cis rs9322193 0.923 rs2297930 chr6:150039496 T/C cg00933542 chr6:150070202 PCMT1 0.31 6.38 0.33 6.16e-10 Lung cancer; CRC cis rs4757319 0.554 rs11023520 chr11:15332935 A/G cg03245590 chr11:15329459 NA -0.53 -9.5 -0.46 4.5e-19 Breast cancer; CRC cis rs7927771 0.524 rs6485763 chr11:47627302 C/T cg20307385 chr11:47447363 PSMC3 0.51 7.54 0.38 4.61e-13 Subjective well-being; CRC cis rs3733585 0.624 rs76574510 chr4:9953252 T/A cg11266682 chr4:10021025 SLC2A9 -0.47 -9.62 -0.47 1.76e-19 Cleft plate (environmental tobacco smoke interaction); CRC cis rs1223397 0.617 rs957176 chr6:13311526 C/T cg20827128 chr6:13274284 PHACTR1 0.38 5.81 0.3 1.5e-8 Blood pressure; CRC cis rs4731207 0.596 rs1552119 chr7:124638876 A/T cg23710748 chr7:124431027 NA -0.39 -6.25 -0.33 1.24e-9 Cutaneous malignant melanoma; CRC cis rs12477438 0.822 rs6727170 chr2:99588042 T/C cg14399236 chr2:99771627 LIPT1;TSGA10 -0.65 -7.94 -0.4 3.14e-14 Chronic sinus infection; CRC cis rs447 0.806 rs933341 chr7:83743619 A/G cg22846510 chr7:83753280 SEMA3A -0.42 -5.76 -0.3 1.95e-8 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg00713605 chr2:232063387 ARMC9 0.41 6.09 0.32 3.1e-9 Intelligence (multi-trait analysis); CRC cis rs9527 0.590 rs7897663 chr10:104905604 T/C cg15744005 chr10:104629667 AS3MT -0.31 -6.1 -0.32 3.03e-9 Arsenic metabolism; CRC cis rs6088580 0.609 rs6059845 chr20:33036500 G/A cg24642439 chr20:33292090 TP53INP2 0.36 6.17 0.32 2.06e-9 Glomerular filtration rate (creatinine); CRC cis rs9584850 0.834 rs4294654 chr13:99119607 G/A cg20487152 chr13:99095054 FARP1 0.41 6.0 0.31 5.28e-9 Neuroticism; CRC cis rs55871839 0.684 rs7829715 chr8:59803836 C/T cg07426533 chr8:59803705 TOX 0.35 6.1 0.32 2.91e-9 Pneumonia; CRC cis rs7301826 0.651 rs12228959 chr12:131296068 T/G cg11011512 chr12:131303247 STX2 0.37 5.62 0.3 4.1e-8 Plasma plasminogen activator levels; CRC cis rs2836974 0.897 rs35391055 chr21:40525516 G/A cg11890956 chr21:40555474 PSMG1 1.1 21.14 0.76 3.07e-63 Cognitive function; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg26938348 chr10:121356513 TIAL1 0.42 6.18 0.32 1.93e-9 Intelligence (multi-trait analysis); CRC cis rs3818285 0.515 rs12258440 chr10:111676799 C/T cg00817464 chr10:111662876 XPNPEP1 -0.5 -6.85 -0.35 3.74e-11 Superior crus of antihelix expression; CRC trans rs2727020 0.638 rs1164668 chr11:49330627 A/C cg11707556 chr5:10655725 ANKRD33B 0.35 6.48 0.34 3.32e-10 Coronary artery disease; CRC cis rs1691799 0.899 rs1168310 chr12:66726355 A/G cg16791601 chr12:66731901 HELB 0.65 10.89 0.51 8.65e-24 White blood cell count (basophil); CRC cis rs17209837 0.607 rs7789645 chr7:87122603 G/C cg00919237 chr7:87102261 ABCB4 -0.51 -6.42 -0.33 4.66e-10 Gallbladder cancer; CRC cis rs1862618 0.853 rs2548664 chr5:56133555 G/A cg18230493 chr5:56204884 C5orf35 -0.71 -9.19 -0.45 4.44e-18 Initial pursuit acceleration; CRC cis rs7618915 0.501 rs7622694 chr3:52663882 G/A cg08222913 chr3:52553049 STAB1 -0.33 -6.24 -0.33 1.35e-9 Bipolar disorder; CRC trans rs7618501 0.633 rs4688755 chr3:50064424 G/A cg21659725 chr3:3221576 CRBN -0.61 -9.59 -0.47 2.32e-19 Intelligence (multi-trait analysis); CRC cis rs12142240 0.698 rs66575205 chr1:46814092 T/G cg00530320 chr1:46809349 NSUN4 0.58 7.81 0.4 7.54e-14 Menopause (age at onset); CRC cis rs172166 0.516 rs2021826 chr6:28132756 G/A cg15845792 chr6:28175446 NA 0.64 9.63 0.47 1.66e-19 Cardiac Troponin-T levels; CRC cis rs7586879 0.639 rs7567997 chr2:25096952 A/G cg22495460 chr2:25135724 ADCY3 -0.81 -15.55 -0.65 2.97e-41 Body mass index; CRC cis rs8030485 0.536 rs12595749 chr15:79432359 A/G cg17916960 chr15:79447300 NA 0.41 6.52 0.34 2.57e-10 Left ventricle wall thickness; CRC cis rs11997175 0.603 rs7001603 chr8:33680978 T/G ch.8.33884649F chr8:33765107 NA 0.43 6.12 0.32 2.65e-9 Body mass index; CRC cis rs951366 0.622 rs11580015 chr1:205676088 G/C cg11965913 chr1:205819406 PM20D1 0.83 12.87 0.58 5.56e-31 Menarche (age at onset); CRC cis rs6951245 1.000 rs74785791 chr7:1088494 T/C cg03188948 chr7:1209495 NA 0.64 6.46 0.34 3.71e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs801193 0.569 rs2659893 chr7:66199993 G/A cg11764359 chr7:65958608 NA 0.59 8.85 0.44 5.43e-17 Aortic root size; CRC cis rs561341 0.739 rs4795663 chr17:30214542 T/C cg13647721 chr17:30228624 UTP6 -0.62 -8.02 -0.4 1.89e-14 Hip circumference adjusted for BMI; CRC cis rs7552404 0.924 rs1611823 chr1:76221706 T/G cg10523679 chr1:76189770 ACADM 0.77 11.71 0.54 1.07e-26 Blood metabolite levels;Acylcarnitine levels; CRC cis rs8180040 0.932 rs12490058 chr3:47529063 T/C cg10298567 chr3:47292165 KIF9 -0.36 -5.91 -0.31 8.57e-9 Colorectal cancer; CRC cis rs9916302 0.706 rs9908131 chr17:37520449 T/C cg00129232 chr17:37814104 STARD3 0.57 7.05 0.36 1.08e-11 Glomerular filtration rate (creatinine); CRC cis rs6460942 0.915 rs62448598 chr7:12453762 T/C cg06484146 chr7:12443880 VWDE -0.78 -8.1 -0.41 1.11e-14 Coronary artery disease; CRC cis rs2836950 0.527 rs2836958 chr21:40623526 T/C cg11644478 chr21:40555479 PSMG1 -0.44 -6.28 -0.33 1.06e-9 Menarche (age at onset); CRC trans rs61931739 0.534 rs11053010 chr12:34093228 G/A cg26384229 chr12:38710491 ALG10B 0.54 6.99 0.36 1.5e-11 Morning vs. evening chronotype; CRC cis rs9486719 1.000 rs13202675 chr6:97028427 C/T cg06623918 chr6:96969491 KIAA0776 -0.82 -9.53 -0.47 3.58e-19 Migraine;Coronary artery disease; CRC cis rs826838 0.620 rs11614695 chr12:39331847 C/T cg26384229 chr12:38710491 ALG10B 0.45 5.78 0.3 1.77e-8 Heart rate; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg01398415 chr1:226309536 NA 0.43 5.97 0.31 6.04e-9 Response to antipsychotic treatment; CRC cis rs10046574 0.561 rs6966294 chr7:135196479 G/A cg27474649 chr7:135195673 CNOT4 0.65 6.08 0.32 3.36e-9 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs1218582 0.744 rs6674853 chr1:154892753 G/C cg16680214 chr1:154839983 KCNN3 -0.5 -9.32 -0.46 1.69e-18 Prostate cancer; CRC cis rs2227564 0.620 rs4746143 chr10:75477298 A/G cg16540259 chr10:75572220 NDST2 0.52 7.65 0.39 2.22e-13 Crohn's disease;Inflammatory bowel disease; CRC cis rs9868809 0.505 rs13434258 chr3:48738491 T/C cg00383909 chr3:49044727 WDR6 0.79 8.04 0.41 1.68e-14 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; CRC cis rs1707322 1.000 rs4454479 chr1:46423555 G/A cg03146154 chr1:46216737 IPP 0.51 7.12 0.37 6.96e-12 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs9399135 0.967 rs1854865 chr6:135360300 C/G cg22676075 chr6:135203613 NA 0.39 5.97 0.31 6.3e-9 Red blood cell count; CRC cis rs7618915 0.501 rs13060048 chr3:52598608 G/A cg10802521 chr3:52805072 NEK4 -0.56 -8.89 -0.44 4e-17 Bipolar disorder; CRC cis rs9296092 0.538 rs62407566 chr6:33535786 C/T cg13560919 chr6:33536144 NA -0.43 -5.84 -0.31 1.24e-8 Age at smoking initiation in chronic obstructive pulmonary disease; CRC trans rs17685 0.625 rs1639630 chr7:75730499 T/C cg19862616 chr7:65841803 NCRNA00174 0.99 18.51 0.71 6.2e-53 Coffee consumption;Coffee consumption (cups per day); CRC cis rs1799949 0.931 rs34474989 chr17:41445410 A/T cg05368731 chr17:41323189 NBR1 0.61 9.46 0.46 5.94e-19 Menopause (age at onset); CRC cis rs7945705 0.967 rs10769973 chr11:8928615 C/G cg00186954 chr11:8933980 ST5;C11orf17 0.46 7.07 0.36 9.28e-12 Hemoglobin concentration; CRC cis rs8114671 0.562 rs3746450 chr20:33508588 G/T cg07148914 chr20:33460835 GGT7 0.39 6.33 0.33 8.21e-10 Height; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg21926875 chr2:47596410 EPCAM 0.35 6.26 0.33 1.18e-9 Liver disease severity in Alagille syndrome; CRC trans rs11722228 0.522 rs7681250 chr4:10133013 G/T cg26043149 chr18:55253948 FECH 1.14 19.64 0.73 2.22e-57 Gout;Urate levels;Serum uric acid levels; CRC cis rs66569888 0.581 rs17271098 chr2:106692818 A/G cg16099169 chr2:106886729 NA 0.44 6.34 0.33 7.51e-10 Facial morphology (factor 23); CRC cis rs9311474 0.967 rs610060 chr3:52273421 G/A cg18099408 chr3:52552593 STAB1 0.43 7.22 0.37 3.73e-12 Electroencephalogram traits; CRC cis rs1832871 0.672 rs9457343 chr6:158740567 A/G cg07165851 chr6:158734300 TULP4 0.63 7.96 0.4 2.75e-14 Height; CRC cis rs9858542 0.953 rs11719996 chr3:49525958 T/C cg03060546 chr3:49711283 APEH -0.47 -6.56 -0.34 2.08e-10 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg01241850 chr9:138798996 CAMSAP1 0.46 6.44 0.33 4.21e-10 Anxiety disorder; CRC cis rs7927771 0.832 rs1317164 chr11:47419757 G/T cg20307385 chr11:47447363 PSMC3 -0.64 -9.31 -0.46 1.83e-18 Subjective well-being; CRC cis rs853679 0.517 rs9393894 chr6:28112562 A/G cg25164649 chr6:28176230 NA 0.78 9.66 0.47 1.33e-19 Depression; CRC cis rs2832191 1.000 rs2832190 chr21:30488226 G/A cg08807101 chr21:30365312 RNF160 -0.62 -10.02 -0.48 8.3e-21 Dental caries; CRC cis rs394563 1.000 rs394563 chr6:149797014 T/G cg16235748 chr6:149772707 ZC3H12D -0.37 -6.41 -0.33 4.98e-10 Dupuytren's disease; CRC cis rs4713118 0.539 rs200951 chr6:27835930 A/G cg08798685 chr6:27730294 NA -0.43 -6.26 -0.33 1.23e-9 Parkinson's disease; CRC cis rs1552244 0.935 rs35586456 chr3:10116938 A/G cg16606324 chr3:10149918 C3orf24 0.7 9.66 0.47 1.31e-19 Alzheimer's disease; CRC cis rs7591163 1.000 rs7574255 chr2:228699884 C/G cg14646075 chr2:228736089 WDR69 0.44 5.88 0.31 9.9e-9 Blood pressure; CRC cis rs12586317 0.576 rs12586302 chr14:35691074 G/C cg07166546 chr14:35805898 NA -0.31 -5.93 -0.31 7.48e-9 Psoriasis; CRC cis rs6582630 0.615 rs11182380 chr12:38511735 G/T cg13010199 chr12:38710504 ALG10B -0.42 -5.93 -0.31 7.61e-9 Drug-induced liver injury (flucloxacillin); CRC trans rs3780486 0.834 rs75443249 chr9:33149207 A/G cg20290983 chr6:43655470 MRPS18A 1.04 16.95 0.68 9.55e-47 IgG glycosylation; CRC cis rs2559856 1.000 rs2695282 chr12:102089502 A/G cg12924262 chr12:102091054 CHPT1 -0.53 -7.86 -0.4 5.7e-14 Blood protein levels; CRC cis rs7618915 0.501 rs34739010 chr3:52766122 A/G cg05573699 chr3:52720067 GNL3;PBRM1 -0.47 -6.83 -0.35 3.99e-11 Bipolar disorder; CRC cis rs116095464 0.558 rs6882584 chr5:223411 A/C cg22857025 chr5:266934 NA -1.23 -16.9 -0.68 1.4300000000000001e-46 Breast cancer; CRC cis rs853679 0.517 rs9357066 chr6:28129831 T/C cg12273811 chr6:28175739 NA 0.73 9.16 0.45 5.8e-18 Depression; CRC cis rs7394190 0.935 rs4746140 chr10:75417249 G/C cg07699608 chr10:75541558 CHCHD1 0.55 6.36 0.33 6.61e-10 Incident atrial fibrillation; CRC cis rs12024301 0.557 rs12067907 chr1:183658255 G/A cg11505048 chr1:183622726 RGL1;APOBEC4 0.7 6.14 0.32 2.38e-9 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs709400 0.663 rs17679475 chr14:103916958 A/G cg12935359 chr14:103987150 CKB -0.47 -7.1 -0.36 7.93e-12 Body mass index; CRC cis rs2243480 1.000 rs316313 chr7:65593548 G/A cg12463550 chr7:65579703 CRCP 0.69 6.4 0.33 5.42e-10 Diabetic kidney disease; CRC cis rs1129187 0.755 rs9471976 chr6:42920549 G/T cg21280719 chr6:42927975 GNMT -0.46 -10.32 -0.49 8.35e-22 Alzheimer's disease in APOE e4+ carriers; CRC cis rs1008375 1.000 rs60178264 chr4:17685308 G/T cg04450456 chr4:17643702 FAM184B 0.39 6.31 0.33 8.97e-10 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs12142240 0.621 rs66828173 chr1:46818166 G/A cg14993813 chr1:46806288 NSUN4 -0.48 -6.18 -0.32 1.87e-9 Menopause (age at onset); CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg04131734 chr11:102323536 TMEM123 0.39 6.11 0.32 2.82e-9 Obesity-related traits; CRC cis rs668210 0.793 rs622779 chr11:65744247 G/A cg02202077 chr11:65769826 EIF1AD;BANF1 -0.57 -7.02 -0.36 1.27e-11 Cerebrospinal fluid biomarker levels; CRC cis rs801193 0.935 rs3800820 chr7:66147178 C/T cg11764359 chr7:65958608 NA -0.54 -8.27 -0.42 3.28e-15 Aortic root size; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg02820958 chr19:7099040 NA 0.41 6.67 0.35 1.05e-10 Liver disease severity in Alagille syndrome; CRC cis rs10504229 0.906 rs116341227 chr8:58190532 G/C cg22535103 chr8:58192502 C8orf71 -0.81 -12.2 -0.56 1.72e-28 Developmental language disorder (linguistic errors); CRC cis rs7613875 0.600 rs2624832 chr3:50030858 C/T cg05623727 chr3:50126028 RBM5 0.6 10.51 0.5 1.78e-22 Body mass index; CRC cis rs4555082 0.957 rs2816629 chr14:105737261 G/A cg06808227 chr14:105710500 BRF1 -0.59 -8.98 -0.44 2.17e-17 Mean platelet volume;Platelet distribution width; CRC cis rs1552244 1.000 rs76041173 chr3:10078695 G/T cg18598329 chr3:10140678 FANCD2;C3orf24 -0.89 -12.0 -0.55 9.46e-28 Alzheimer's disease; CRC cis rs9649213 0.593 rs10953255 chr7:97923198 A/G cg21770322 chr7:97807741 LMTK2 0.52 8.51 0.42 6.16e-16 Prostate cancer (SNP x SNP interaction); CRC trans rs34421088 0.560 rs2248316 chr8:11397073 A/C cg16141378 chr3:129829833 LOC729375 0.46 6.83 0.35 4.18e-11 Neuroticism; CRC cis rs6740322 0.895 rs28456986 chr2:43553321 A/C cg06169590 chr2:43455088 ZFP36L2;LOC100129726 -0.62 -7.51 -0.38 5.8e-13 Coronary artery disease; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg10010189 chr2:60983202 PAPOLG 0.46 6.88 0.35 3.03e-11 Response to antipsychotic treatment; CRC cis rs4819052 0.851 rs7276103 chr21:46666078 G/A cg19498844 chr21:46707878 POFUT2;LOC642852 0.65 9.5 0.46 4.4e-19 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs2075371 1.000 rs2544218 chr7:133992315 C/A cg11752832 chr7:134001865 SLC35B4 0.5 7.7 0.39 1.56e-13 Mean platelet volume; CRC cis rs2120019 1.000 rs67544533 chr15:75361539 A/G cg17294928 chr15:75287854 SCAMP5 -0.75 -11.35 -0.53 2.06e-25 Blood trace element (Zn levels); CRC cis rs977987 0.806 rs35263058 chr16:75391937 T/C cg03315344 chr16:75512273 CHST6 0.52 8.8 0.44 8.16e-17 Dupuytren's disease; CRC cis rs10504229 0.679 rs72649119 chr8:58040301 T/C cg22535103 chr8:58192502 C8orf71 -0.44 -5.81 -0.3 1.49e-8 Developmental language disorder (linguistic errors); CRC cis rs150647904 1 rs150647904 chr1:54839485 T/TCAG cg17417004 chr1:54819992 SSBP3 0.69 8.16 0.41 7.06e-15 Platelet distribution width; CRC cis rs2228479 0.717 rs62052210 chr16:89980158 A/G cg06558623 chr16:89946397 TCF25 0.83 9.18 0.45 4.95e-18 Skin colour saturation; CRC cis rs4474465 0.850 rs10899538 chr11:78237749 C/T cg02023728 chr11:77925099 USP35 -0.34 -5.64 -0.3 3.64e-8 Alzheimer's disease (survival time); CRC cis rs9900062 0.546 rs2676294 chr17:62710764 A/G cg02097616 chr17:62675921 NA -0.52 -7.41 -0.38 1.07e-12 QT interval; CRC cis rs2836974 0.666 rs4624474 chr21:40686327 T/C cg06238570 chr21:40685208 BRWD1 -0.85 -13.5 -0.6 2.41e-33 Cognitive function; CRC cis rs9902453 0.845 rs116840018 chr17:28232049 G/A cg26525008 chr17:28256777 EFCAB5;SSH2 0.59 8.8 0.44 7.67e-17 Coffee consumption (cups per day); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg06905471 chr2:29092871 TRMT61B 0.49 6.91 0.36 2.54e-11 Response to antipsychotic treatment; CRC cis rs1129187 0.818 rs9462858 chr6:42946490 C/A cg26304593 chr6:42947056 PEX6 -0.41 -5.84 -0.31 1.24e-8 Alzheimer's disease in APOE e4+ carriers; CRC cis rs7618915 0.571 rs12632381 chr3:52607685 G/A cg05573699 chr3:52720067 GNL3;PBRM1 -0.44 -6.27 -0.33 1.14e-9 Bipolar disorder; CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg05704155 chr1:10459140 PGD 0.38 6.1 0.32 3.04e-9 Obesity-related traits; CRC cis rs10504229 1.000 rs75037501 chr8:58170136 T/G cg05313129 chr8:58192883 C8orf71 -0.47 -6.99 -0.36 1.49e-11 Developmental language disorder (linguistic errors); CRC cis rs9309711 0.961 rs35067331 chr2:3474085 C/T cg10845886 chr2:3471009 TTC15 -0.73 -11.9 -0.55 2.13e-27 Neurofibrillary tangles; CRC cis rs7618501 0.516 rs2856236 chr3:50161717 A/C cg05623727 chr3:50126028 RBM5 -0.46 -7.63 -0.39 2.57e-13 Intelligence (multi-trait analysis); CRC cis rs6534441 0.697 rs58633746 chr4:125466433 A/G cg21609808 chr4:125404261 NA 0.41 5.65 0.3 3.52e-8 Major depressive disorder; CRC cis rs8031584 0.706 rs798084 chr15:31126935 C/T cg08109568 chr15:31115862 NA -0.65 -10.26 -0.49 1.32e-21 Huntington's disease progression; CRC cis rs7666738 0.830 rs79075162 chr4:98960674 A/T cg17366294 chr4:99064904 C4orf37 0.43 7.34 0.38 1.69e-12 Colonoscopy-negative controls vs population controls; CRC cis rs2281845 0.929 rs6413915 chr1:201091041 A/C cg17810781 chr1:201082982 CACNA1S -0.49 -8.67 -0.43 2.04e-16 Permanent tooth development; CRC cis rs1223397 1.000 rs1223402 chr6:13271640 G/A cg00460589 chr6:13274354 PHACTR1 0.45 5.63 0.3 3.83e-8 Blood pressure; CRC cis rs2836974 0.627 rs9981301 chr21:40686078 G/C cg17971929 chr21:40555470 PSMG1 -0.64 -9.27 -0.46 2.45e-18 Cognitive function; CRC cis rs6502050 0.799 rs7406257 chr17:80089340 G/A cg02741985 chr17:80059408 CCDC57 0.43 7.13 0.37 6.48e-12 Life satisfaction; CRC cis rs6502050 0.835 rs3088177 chr17:80111724 A/G cg22110888 chr17:80059540 CCDC57 0.4 6.37 0.33 6.22e-10 Life satisfaction; CRC cis rs992157 0.835 rs7559416 chr2:219150211 A/G cg20019365 chr2:219134978 PNKD;AAMP -0.41 -5.93 -0.31 7.77e-9 Colorectal cancer; CRC trans rs7618501 0.602 rs2526743 chr3:50115245 G/A cg21665057 chr3:196295764 WDR53;FBXO45 -0.58 -9.35 -0.46 1.43e-18 Intelligence (multi-trait analysis); CRC cis rs13118159 0.527 rs1250119 chr4:1261336 G/A cg05025164 chr4:1340916 KIAA1530 -0.59 -8.2 -0.41 5.43e-15 Longevity; CRC cis rs11969893 0.649 rs9498408 chr6:101292340 C/T cg12253828 chr6:101329408 ASCC3 0.85 7.78 0.39 9.33e-14 Economic and political preferences (immigration/crime); CRC cis rs4253772 0.515 rs77797820 chr22:46771270 C/T cg24881330 chr22:46731750 TRMU 0.67 5.71 0.3 2.56e-8 LDL cholesterol;Cholesterol, total; CRC cis rs7647973 0.710 rs6446284 chr3:49616997 A/G cg03060546 chr3:49711283 APEH 0.66 7.37 0.38 1.41e-12 Menarche (age at onset); CRC cis rs6500602 0.701 rs1362626 chr16:4549226 C/G cg13763550 chr16:4524223 NMRAL1;HMOX2 0.44 6.08 0.32 3.36e-9 Schizophrenia; CRC cis rs12541635 0.677 rs61002083 chr8:106982132 A/G cg10147462 chr8:107024639 NA 0.56 9.81 0.48 4.21e-20 Age of smoking initiation; CRC cis rs10207060 0.500 rs7600350 chr2:240716225 T/C cg07506560 chr2:240697449 NA 0.42 5.62 0.3 4.17e-8 Obesity-related traits; CRC cis rs9359856 0.564 rs72913954 chr6:90361589 T/C cg13799429 chr6:90582589 CASP8AP2 -0.75 -7.69 -0.39 1.69e-13 Bipolar disorder; CRC cis rs6502050 0.835 rs9898697 chr17:80100498 A/G cg22110888 chr17:80059540 CCDC57 0.41 6.52 0.34 2.71e-10 Life satisfaction; CRC cis rs10493773 0.609 rs11161660 chr1:86184066 C/T cg00734567 chr1:86172782 ZNHIT6 -0.47 -7.23 -0.37 3.42e-12 Urate levels in overweight individuals; CRC cis rs9547692 1.000 rs493248 chr13:37473386 C/T cg01493522 chr13:37497338 NA -0.49 -6.98 -0.36 1.6e-11 Coronary artery disease; CRC cis rs9303280 0.806 rs9904624 chr17:38036586 A/G cg00129232 chr17:37814104 STARD3 -0.43 -6.91 -0.36 2.47e-11 Self-reported allergy; CRC cis rs72781680 0.898 rs113522526 chr2:24018476 C/T cg08917208 chr2:24149416 ATAD2B 0.85 8.47 0.42 8.05e-16 Lymphocyte counts; CRC cis rs2115630 1.000 rs6496452 chr15:85372645 A/T cg11189052 chr15:85197271 WDR73 -0.58 -9.64 -0.47 1.54e-19 P wave terminal force; CRC cis rs9747201 1.000 rs57405744 chr17:80177465 A/G cg23141183 chr17:80185318 SLC16A3 0.43 6.04 0.32 4.08e-9 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs13118159 0.934 rs4974608 chr4:1356780 C/T cg15763984 chr4:1342303 KIAA1530 0.36 6.15 0.32 2.21e-9 Longevity; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg07210462 chr1:39324918 RRAGC 0.48 6.96 0.36 1.83e-11 Response to antipsychotic treatment; CRC cis rs2153535 0.580 rs1034272 chr6:8469335 G/C cg07606381 chr6:8435919 SLC35B3 0.68 10.94 0.52 6e-24 Motion sickness; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg10338082 chr3:124303555 KALRN 0.4 6.65 0.34 1.19e-10 Liver disease severity in Alagille syndrome; CRC cis rs3540 0.960 rs28539372 chr15:91021412 T/A cg04176472 chr15:90893244 GABARAPL3 0.36 6.21 0.32 1.63e-9 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; CRC cis rs75920871 0.502 rs10790166 chr11:116779499 A/G cg20608306 chr11:116969690 SIK3 -0.31 -5.74 -0.3 2.17e-8 Subjective well-being; CRC cis rs1448094 0.527 rs1900700 chr12:86232166 C/T cg02569458 chr12:86230093 RASSF9 0.46 7.79 0.39 8.63e-14 Major depressive disorder; CRC cis rs12701220 0.522 rs12334290 chr7:1054517 A/G cg02733842 chr7:1102375 C7orf50 -0.42 -5.77 -0.3 1.85e-8 Bronchopulmonary dysplasia; CRC cis rs7215564 0.908 rs4889883 chr17:78664374 C/A cg09596252 chr17:78655493 RPTOR 0.56 6.11 0.32 2.76e-9 Myopia (pathological); CRC cis rs4713118 0.591 rs2056924 chr6:27690174 G/A cg15786705 chr6:28176104 NA 0.49 6.99 0.36 1.58e-11 Parkinson's disease; CRC cis rs6840360 0.593 rs4696106 chr4:152606818 A/G cg09659197 chr4:152720779 NA 0.4 7.93 0.4 3.4e-14 Intelligence (multi-trait analysis); CRC trans rs7267979 1.000 rs6083813 chr20:25337671 A/G cg17903999 chr18:56338584 MALT1 0.43 7.12 0.37 6.83e-12 Liver enzyme levels (alkaline phosphatase); CRC cis rs6951245 1.000 rs111899361 chr7:1112348 C/T cg22907277 chr7:1156413 C7orf50 0.75 7.95 0.4 3.04e-14 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs1865760 0.892 rs6456705 chr6:25936056 G/A cg16482183 chr6:26056742 HIST1H1C 0.54 7.44 0.38 9.04e-13 Height; CRC cis rs1403694 1.000 rs1648716 chr3:186439529 C/T cg04611788 chr3:186434169 KNG1 -0.45 -6.97 -0.36 1.69e-11 Blood protein levels; CRC cis rs6502050 0.835 rs3935403 chr17:80114145 C/T cg02741985 chr17:80059408 CCDC57 0.43 7.2 0.37 4.16e-12 Life satisfaction; CRC cis rs6087990 0.806 rs910084 chr20:31379665 C/T cg13636640 chr20:31349939 DNMT3B 0.78 14.68 0.63 7.2e-38 Ulcerative colitis; CRC cis rs7618501 0.602 rs10049087 chr3:50123417 A/G cg24110177 chr3:50126178 RBM5 0.48 7.17 0.37 4.97e-12 Intelligence (multi-trait analysis); CRC cis rs9399135 0.527 rs61738492 chr6:135282771 G/A cg24558204 chr6:135376177 HBS1L 0.61 8.8 0.44 7.65e-17 Red blood cell count; CRC trans rs2303319 0.504 rs12467662 chr2:162386784 G/A cg27113153 chr11:123612418 ZNF202 -0.72 -6.15 -0.32 2.25e-9 Cognitive function; CRC cis rs832540 0.830 rs252907 chr5:56120646 G/A cg03609598 chr5:56110824 MAP3K1 -0.45 -6.23 -0.32 1.44e-9 Coronary artery disease; CRC cis rs11785400 1.000 rs7459630 chr8:143738585 A/C cg10596483 chr8:143751796 JRK 0.5 6.95 0.36 1.93e-11 Schizophrenia; CRC cis rs68170813 0.523 rs3757713 chr7:107042750 A/C cg02696742 chr7:106810147 HBP1 -0.58 -6.04 -0.32 4.16e-9 Coronary artery disease; CRC cis rs853679 0.517 rs9368558 chr6:28133306 A/G cg02683197 chr6:28174875 NA 0.87 10.73 0.51 3.25e-23 Depression; CRC cis rs12575642 0.660 rs58632573 chr11:63896299 C/T cg04317338 chr11:64019027 PLCB3 0.6 7.36 0.38 1.47e-12 Attention deficit hyperactivity disorder; CRC cis rs1728785 0.901 rs11075687 chr16:68655894 T/C cg02972257 chr16:68554789 NA -0.56 -6.72 -0.35 8.25e-11 Ulcerative colitis; CRC cis rs7607369 0.648 rs55983650 chr2:219654932 T/C cg02176678 chr2:219576539 TTLL4 -0.57 -8.9 -0.44 3.78e-17 Red blood cell count;Amyotrophic lateral sclerosis; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg27391037 chr22:18560705 PEX26 0.39 6.02 0.31 4.57e-9 Intelligence (multi-trait analysis); CRC cis rs758324 0.898 rs510434 chr5:131292503 C/T cg06307176 chr5:131281290 NA -0.39 -5.74 -0.3 2.1e-8 Alzheimer's disease in APOE e4- carriers; CRC cis rs10489202 0.608 rs7553238 chr1:168076768 G/A cg24449463 chr1:168025552 DCAF6 -0.53 -7.33 -0.37 1.78e-12 Schizophrenia; CRC cis rs9648716 0.554 rs801093 chr7:140653145 T/G cg10747023 chr7:140774559 NA 0.43 5.99 0.31 5.45e-9 Type 2 diabetes; CRC cis rs1865760 1.000 rs2071299 chr6:25914801 G/A cg16482183 chr6:26056742 HIST1H1C 0.55 7.96 0.4 2.84e-14 Height; CRC cis rs9297145 0.724 rs62473013 chr7:98762418 G/T cg05967295 chr7:98741636 SMURF1 1.14 17.8 0.7 3.94e-50 Crohn's disease;Inflammatory bowel disease;Ulcerative colitis; CRC cis rs11105298 0.891 rs11105325 chr12:89938590 G/A cg08166232 chr12:89918718 WDR51B;GALNT4 -0.61 -7.5 -0.38 5.91e-13 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; CRC cis rs763014 0.966 rs15564 chr16:677854 G/T cg07256732 chr16:621771 PIGQ -0.36 -5.67 -0.3 3.05e-8 Height; CRC trans rs2856321 0.874 rs1009951 chr12:11892896 C/T cg04981696 chr16:16044519 ABCC1 0.42 6.0 0.31 5.21e-9 Height; CRC cis rs12410462 0.681 rs4614224 chr1:227574966 C/T cg04117972 chr1:227635322 NA 0.65 6.06 0.32 3.8e-9 Major depressive disorder; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg04686114 chr12:57081832 PTGES3 0.47 7.53 0.38 5.02e-13 Liver disease severity in Alagille syndrome; CRC cis rs6502050 0.835 rs7209474 chr17:80136418 C/T cg25804541 chr17:80189381 SLC16A3 -0.31 -5.88 -0.31 1.02e-8 Life satisfaction; CRC trans rs57221529 0.709 rs72703034 chr5:577101 C/T cg11887960 chr12:57824829 NA 0.62 6.76 0.35 6.26e-11 Lung disease severity in cystic fibrosis; CRC cis rs9488822 0.597 rs12214881 chr6:116342187 G/T cg05304507 chr6:116381966 FRK 0.31 8.4 0.42 1.32e-15 Cholesterol, total;LDL cholesterol; CRC cis rs6840360 0.642 rs2709819 chr4:152383832 A/G cg09659197 chr4:152720779 NA 0.33 6.51 0.34 2.77e-10 Intelligence (multi-trait analysis); CRC cis rs1552244 1.000 rs61052895 chr3:10147516 G/A cg00166722 chr3:10149974 C3orf24 0.69 9.17 0.45 5.48e-18 Alzheimer's disease; CRC cis rs801193 0.613 rs2659900 chr7:66184443 G/C cg12463550 chr7:65579703 CRCP 0.44 6.07 0.32 3.46e-9 Aortic root size; CRC cis rs11009175 0.556 rs7072034 chr10:33298617 A/G cg00146027 chr10:33299147 NA -0.28 -6.29 -0.33 1.02e-9 Depression (quantitative trait); CRC cis rs10782582 0.593 rs11576534 chr1:76112751 C/T cg10523679 chr1:76189770 ACADM -0.43 -6.04 -0.32 4.15e-9 Daytime sleep phenotypes; CRC cis rs7772486 0.875 rs9373483 chr6:146364194 A/G cg05347473 chr6:146136440 FBXO30 0.37 5.89 0.31 9.38e-9 Lobe attachment (rater-scored or self-reported); CRC trans rs2727020 0.688 rs11040338 chr11:49360601 A/G cg21153622 chr11:89784906 NA 0.43 7.12 0.37 6.72e-12 Coronary artery disease; CRC cis rs1107366 1.000 rs9873704 chr3:125901902 G/C cg20988073 chr3:125900093 ALDH1L1 -0.35 -6.01 -0.31 4.92e-9 Metabolite levels; CRC cis rs853679 1.000 rs1778511 chr6:28229411 G/A cg06470822 chr6:28175283 NA -0.65 -6.69 -0.35 9.59e-11 Depression; CRC cis rs769267 0.895 rs2905435 chr19:19495954 G/A cg02546618 chr19:19431379 KIAA0892;SF4 -0.45 -6.31 -0.33 9.14e-10 Tonsillectomy; CRC cis rs853679 0.517 rs56364346 chr6:28050762 T/G cg18032046 chr6:28092343 ZSCAN16 -0.5 -5.94 -0.31 7.43e-9 Depression; CRC cis rs3796352 1.000 rs13076033 chr3:52898427 T/C cg07884673 chr3:53033167 SFMBT1 0.77 6.17 0.32 2.05e-9 Immune reponse to smallpox (secreted IL-2); CRC cis rs9611565 0.918 rs73176685 chr22:41781094 C/G cg03806693 chr22:41940476 POLR3H -0.95 -12.21 -0.56 1.58e-28 Vitiligo; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg25721516 chr17:42276931 ATXN7L3 0.43 6.99 0.36 1.53e-11 Liver disease severity in Alagille syndrome; CRC cis rs253959 0.629 rs10054121 chr5:115419968 G/A cg23108291 chr5:115420582 COMMD10 0.44 6.24 0.33 1.36e-9 Bipolar disorder and schizophrenia; CRC cis rs9875589 0.957 rs1579551 chr3:13945571 C/G cg19554555 chr3:13937349 NA -0.43 -6.22 -0.32 1.54e-9 Ovarian reserve; CRC cis rs10464366 0.879 rs10464368 chr7:39121581 C/T cg18850127 chr7:39170497 POU6F2 0.43 5.77 0.3 1.8e-8 IgG glycosylation; CRC cis rs1997103 0.911 rs11238361 chr7:55395981 A/G cg17469321 chr7:55412551 NA 0.74 11.44 0.53 9.61e-26 QRS interval (sulfonylurea treatment interaction); CRC cis rs9443189 1.000 rs3822957 chr6:76607280 A/G cg01950844 chr6:76311363 SENP6 -0.59 -7.16 -0.37 5.17e-12 Prostate cancer; CRC cis rs35264875 0.950 rs72928659 chr11:68852358 C/T cg03469862 chr11:68924853 NA 0.46 5.89 0.31 9.37e-9 Blond vs. brown hair color; CRC cis rs853679 1.000 rs1419183 chr6:28242794 A/C cg15845792 chr6:28175446 NA 0.65 6.49 0.34 3.17e-10 Depression; CRC cis rs2836974 0.897 rs14194 chr21:40549466 T/C cg11644478 chr21:40555479 PSMG1 0.83 12.68 0.57 2.87e-30 Cognitive function; CRC cis rs10504229 0.728 rs59266065 chr8:58156236 A/G cg20607798 chr8:58055168 NA 0.46 5.74 0.3 2.13e-8 Developmental language disorder (linguistic errors); CRC cis rs514406 0.505 rs6688064 chr1:53165609 C/T cg08859206 chr1:53392774 SCP2 -0.4 -6.11 -0.32 2.87e-9 Monocyte count; CRC cis rs7762018 0.769 rs4716339 chr6:170063210 C/T cg19338460 chr6:170058176 WDR27 -0.81 -8.27 -0.42 3.26e-15 Thiazide-induced adverse metabolic effects in hypertensive patients; CRC cis rs10504229 0.683 rs6999131 chr8:58127052 C/A cg08219700 chr8:58056026 NA 0.57 6.86 0.35 3.52e-11 Developmental language disorder (linguistic errors); CRC trans rs6940638 0.956 rs36048693 chr6:27032711 T/G cg06470822 chr6:28175283 NA 0.59 6.47 0.34 3.5e-10 Intelligence (multi-trait analysis); CRC cis rs6840360 0.582 rs6535796 chr4:152304728 G/A cg09659197 chr4:152720779 NA 0.3 5.75 0.3 2.08e-8 Intelligence (multi-trait analysis); CRC cis rs11247915 0.600 rs3795686 chr1:26582091 G/A cg04990556 chr1:26633338 UBXN11 -0.47 -5.69 -0.3 2.78e-8 Obesity-related traits; CRC cis rs6681460 0.966 rs2025595 chr1:67152499 G/A cg02459107 chr1:67143332 SGIP1 0.4 7.03 0.36 1.18e-11 Presence of antiphospholipid antibodies; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg08040170 chr16:18812977 ARL6IP1 0.49 6.85 0.35 3.62e-11 Response to antipsychotic treatment; CRC cis rs1707322 0.716 rs6699444 chr1:46135120 G/C cg03146154 chr1:46216737 IPP 0.66 9.65 0.47 1.44e-19 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs6460942 0.591 rs4721080 chr7:12337785 T/C cg06484146 chr7:12443880 VWDE -0.6 -6.59 -0.34 1.75e-10 Coronary artery disease; CRC cis rs6933660 0.744 rs3800279 chr6:151766162 T/C cg14416726 chr6:151773293 C6orf211;RMND1 -0.41 -5.78 -0.3 1.71e-8 Menarche (age at onset); CRC cis rs10504229 0.679 rs6995378 chr8:58113933 C/T cg05313129 chr8:58192883 C8orf71 -0.43 -6.0 -0.31 5.07e-9 Developmental language disorder (linguistic errors); CRC cis rs28386778 0.897 rs7210443 chr17:61785374 A/G cg25654072 chr17:61904446 PSMC5;FTSJ3 0.73 11.22 0.53 5.77e-25 Prudent dietary pattern; CRC cis rs1707322 0.647 rs6686944 chr1:46156308 G/T cg03146154 chr1:46216737 IPP 0.68 10.0 0.48 1e-20 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs782590 0.556 rs782579 chr2:55917604 A/G cg18811423 chr2:55921094 PNPT1 0.81 14.3 0.62 2.07e-36 Metabolic syndrome; CRC cis rs2576037 0.899 rs7233515 chr18:44585955 A/G cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.54 -7.84 -0.4 6.47e-14 Personality dimensions; CRC trans rs17685 0.753 rs1637045 chr7:75703895 T/C cg19862616 chr7:65841803 NCRNA00174 1.0 18.6 0.72 2.7e-53 Coffee consumption;Coffee consumption (cups per day); CRC trans rs7267979 0.714 rs6132825 chr20:25238309 A/T cg17903999 chr18:56338584 MALT1 -0.43 -6.74 -0.35 6.9e-11 Liver enzyme levels (alkaline phosphatase); CRC cis rs4147929 0.625 rs4147934 chr19:1065018 G/T cg26576206 chr19:1064938 ABCA7 0.42 5.96 0.31 6.6e-9 Alzheimer's disease (late onset); CRC cis rs270601 0.690 rs162904 chr5:131595784 C/T cg04518342 chr5:131593106 PDLIM4 -0.5 -8.44 -0.42 1.02e-15 Acylcarnitine levels; CRC cis rs704795 0.836 rs1647281 chr2:27612938 G/C cg27432699 chr2:27873401 GPN1 -0.5 -7.56 -0.38 3.99e-13 Menopause (age at onset); CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg12843872 chr7:90894352 FZD1 -0.51 -6.36 -0.33 6.57e-10 Diisocyanate-induced asthma; CRC cis rs3091242 0.933 rs61775174 chr1:25787313 G/A cg02931644 chr1:25747376 RHCE -0.33 -5.67 -0.3 3.16e-8 Erythrocyte sedimentation rate; CRC cis rs10991814 0.920 rs6479335 chr9:94108790 T/C cg14446406 chr9:93919335 NA 0.59 6.66 0.34 1.13e-10 Neutrophil percentage of granulocytes; CRC cis rs807669 0.772 rs809901 chr22:19228736 C/T cg02655711 chr22:19163373 SLC25A1 0.75 13.9 0.61 7.15e-35 Metabolite levels; CRC cis rs2346160 0.831 rs1467391 chr6:167690062 A/G cg27333441 chr6:167680455 NA -0.4 -6.63 -0.34 1.4e-10 Parental extreme longevity (95 years and older); CRC cis rs597539 0.617 rs669659 chr11:68635623 G/C cg04772025 chr11:68637568 NA 0.5 7.8 0.4 8.12e-14 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs1395 0.744 rs7600932 chr2:27474869 G/A cg14242246 chr2:27434262 C2orf28;SLC5A6 0.32 6.21 0.32 1.55e-9 Blood metabolite levels; CRC cis rs7777484 0.534 rs2533890 chr7:2828743 C/T cg19717773 chr7:2847554 GNA12 -0.51 -8.95 -0.44 2.72e-17 Height; CRC cis rs10870270 1.000 rs3935905 chr10:133758262 A/C cg08754478 chr10:133766260 PPP2R2D -0.67 -9.66 -0.47 1.37e-19 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; CRC cis rs758324 0.812 rs4705839 chr5:131175258 G/A cg25547332 chr5:131281432 NA 0.37 5.86 0.31 1.14e-8 Alzheimer's disease in APOE e4- carriers; CRC cis rs1552244 0.572 rs17032440 chr3:10169819 A/C cg10729496 chr3:10149963 C3orf24 -0.5 -5.82 -0.31 1.4e-8 Alzheimer's disease; CRC cis rs17376456 0.877 rs10055340 chr5:93317644 T/C cg25358565 chr5:93447407 FAM172A 1.05 10.89 0.51 8.72e-24 Diabetic retinopathy; CRC cis rs7618501 0.602 rs10049087 chr3:50123417 A/G cg05623727 chr3:50126028 RBM5 -0.45 -7.38 -0.38 1.33e-12 Intelligence (multi-trait analysis); CRC cis rs2404602 0.660 rs11852777 chr15:76929792 A/G cg23625390 chr15:77176239 SCAPER -0.85 -13.47 -0.6 3.03e-33 Blood metabolite levels; CRC cis rs6696846 0.905 rs11240349 chr1:205041015 G/A cg00857998 chr1:205179979 DSTYK 0.43 5.84 0.31 1.24e-8 Red blood cell count; CRC cis rs9894429 0.646 rs7406522 chr17:79615396 G/T cg18240062 chr17:79603768 NPLOC4 0.46 7.21 0.37 3.82e-12 Eye color traits; CRC cis rs2386661 0.547 rs11259582 chr10:5646767 C/T cg02449762 chr10:5661741 NA -0.33 -5.75 -0.3 2.06e-8 Breast cancer; CRC cis rs4434138 0.683 rs13063160 chr3:52602274 T/C cg18404041 chr3:52824283 ITIH1 -0.4 -8.41 -0.42 1.27e-15 Intelligence (multi-trait analysis); CRC cis rs4853036 0.951 rs6718298 chr2:70145450 A/C cg02498382 chr2:70120550 SNRNP27 -0.46 -7.04 -0.36 1.09e-11 Colorectal or endometrial cancer; CRC cis rs17767392 0.958 rs12889866 chr14:71937439 C/T cg13720639 chr14:72061746 SIPA1L1 -0.56 -7.17 -0.37 5.11e-12 Mitral valve prolapse; CRC cis rs10504229 1.000 rs67243305 chr8:58174958 G/A cg05313129 chr8:58192883 C8orf71 -0.47 -6.97 -0.36 1.69e-11 Developmental language disorder (linguistic errors); CRC cis rs7949030 0.620 rs2428551 chr11:62329758 T/A cg22862634 chr11:62369728 EML3;MTA2 0.55 10.09 0.49 4.98e-21 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; CRC cis rs6860806 0.531 rs272887 chr5:131665713 A/G cg18758796 chr5:131593413 PDLIM4 0.39 6.24 0.33 1.32e-9 Breast cancer; CRC cis rs1799949 0.965 rs799910 chr17:41279561 G/C cg25072359 chr17:41440525 NA 0.53 8.58 0.43 3.87e-16 Menopause (age at onset); CRC cis rs1881797 0.932 rs2387038 chr1:247674919 G/A cg05639522 chr1:247681581 NA 0.49 7.15 0.37 5.55e-12 Acute lymphoblastic leukemia (childhood); CRC cis rs728616 0.681 rs12413174 chr10:82062404 G/A cg05935833 chr10:81318306 SFTPA2 -0.59 -7.03 -0.36 1.18e-11 Chronic obstructive pulmonary disease-related biomarkers; CRC trans rs10504229 1.000 rs73607871 chr8:58173007 T/C cg04077850 chr5:125800366 GRAMD3 0.37 6.27 0.33 1.15e-9 Developmental language disorder (linguistic errors); CRC trans rs2303319 0.504 rs56260047 chr2:162497225 G/T cg06896663 chr8:82754093 SNX16 -0.68 -6.1 -0.32 3.01e-9 Cognitive function; CRC cis rs2836974 0.568 rs7282604 chr21:40536910 C/T cg11644478 chr21:40555479 PSMG1 -0.73 -12.19 -0.56 1.9e-28 Cognitive function; CRC cis rs728616 0.681 rs36073865 chr10:81916055 C/T cg11900509 chr10:81946545 ANXA11 -0.72 -8.65 -0.43 2.25e-16 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs11190604 1.000 rs7090431 chr10:102261753 A/G cg07080220 chr10:102295463 HIF1AN 0.45 5.67 0.3 3.19e-8 Palmitoleic acid (16:1n-7) levels; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg16310774 chr5:64920439 C5orf44;TRIM23 0.43 6.0 0.31 5.25e-9 Response to antipsychotic treatment; CRC cis rs1862618 0.525 rs2662019 chr5:56263104 A/G cg18230493 chr5:56204884 C5orf35 0.73 10.02 0.48 8.53e-21 Initial pursuit acceleration; CRC cis rs10463316 0.817 rs1318783 chr5:150814807 T/G cg03212797 chr5:150827313 SLC36A1 -0.55 -8.41 -0.42 1.29e-15 Metabolite levels (Pyroglutamine); CRC cis rs7618915 0.501 rs2109634 chr3:52752075 T/G cg18099408 chr3:52552593 STAB1 -0.46 -7.71 -0.39 1.48e-13 Bipolar disorder; CRC cis rs10927875 0.722 rs6696912 chr1:16338474 T/C cg21385522 chr1:16154831 NA 0.61 7.68 0.39 1.85e-13 Dilated cardiomyopathy; CRC cis rs28655083 1.000 rs7198870 chr16:77072963 C/T cg01753188 chr16:77233325 SYCE1L;MON1B -0.53 -7.53 -0.38 4.8e-13 Lobe attachment (rater-scored or self-reported); CRC cis rs7493 0.853 rs17166879 chr7:95053415 A/G cg04155289 chr7:94953770 PON1 -0.63 -7.73 -0.39 1.32e-13 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs3771570 1.000 rs62193171 chr2:242276523 C/A cg21155796 chr2:242212141 HDLBP 0.64 6.97 0.36 1.72e-11 Prostate cancer; CRC cis rs13108904 0.870 rs12499546 chr4:1255194 C/T cg20887711 chr4:1340912 KIAA1530 0.41 5.86 0.31 1.1e-8 Obesity-related traits; CRC cis rs3767633 0.800 rs6685369 chr1:161754834 T/C cg09175582 chr1:161736000 ATF6 0.66 6.13 0.32 2.58e-9 IgG glycosylation; CRC cis rs9611565 0.512 rs9611667 chr22:42187015 C/T cg06481639 chr22:41940642 POLR3H -0.56 -6.17 -0.32 2.01e-9 Vitiligo; CRC cis rs6951245 1.000 rs74652290 chr7:1090109 G/A cg24642844 chr7:1081250 C7orf50 -0.77 -9.45 -0.46 6.64e-19 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC trans rs916888 0.610 rs199436 chr17:44789285 C/T cg01341218 chr17:43662625 NA -0.63 -7.89 -0.4 4.42e-14 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs9648716 1.000 rs11974112 chr7:140641544 G/A cg10747023 chr7:140774559 NA 0.47 6.04 0.32 4.27e-9 Type 2 diabetes; CRC trans rs561341 1.000 rs2470267 chr17:30274132 G/A cg20587970 chr11:113659929 NA -1.14 -16.06 -0.66 2.87e-43 Hip circumference adjusted for BMI; CRC trans rs8123881 0.733 rs7268466 chr20:15810676 C/T cg25755261 chr14:35591781 PPP2R3C;KIAA0391 0.58 6.04 0.32 4.08e-9 Body mass index; CRC cis rs6952808 0.929 rs2280550 chr7:1976556 G/A cg00106254 chr7:1943704 MAD1L1 -0.47 -6.53 -0.34 2.46e-10 Bipolar disorder and schizophrenia; CRC trans rs3942852 0.868 rs58407618 chr11:48104167 T/G cg03929089 chr4:120376271 NA -0.56 -6.48 -0.34 3.28e-10 Acute lymphoblastic leukemia (childhood); CRC trans rs7615952 0.512 rs11921452 chr3:125359750 A/G cg16558177 chr4:4109446 NA -0.62 -8.74 -0.43 1.23e-16 Blood pressure (smoking interaction); CRC cis rs7258465 1.000 rs76194 chr19:18630580 T/G cg10790698 chr19:18539756 SSBP4 -0.46 -8.79 -0.44 8.55e-17 Breast cancer; CRC trans rs264943 0.600 rs2257063 chr2:104092954 C/T cg24033067 chr14:24674799 TSSK4 -0.41 -6.01 -0.31 4.94e-9 HIV-1 viral setpoint; CRC cis rs763014 0.966 rs4984675 chr16:670117 T/C cg00908189 chr16:619842 PIGQ 0.67 10.97 0.52 4.4e-24 Height; CRC cis rs2153535 0.580 rs1335633 chr6:8448800 C/T cg21535247 chr6:8435926 SLC35B3 0.5 7.5 0.38 6.06e-13 Motion sickness; CRC cis rs1957429 0.634 rs59000318 chr14:65419473 C/A cg23373153 chr14:65346875 NA -0.82 -6.89 -0.36 2.86e-11 Pediatric areal bone mineral density (radius); CRC cis rs17818399 0.620 rs1598517 chr2:46857401 C/T cg26688816 chr2:46740690 ATP6V1E2 -0.42 -6.25 -0.33 1.28e-9 Height; CRC cis rs9467711 0.790 rs1979 chr6:26377591 G/T cg14345882 chr6:26364793 BTN3A2 0.68 5.84 0.31 1.25e-8 Autism spectrum disorder or schizophrenia; CRC cis rs875971 0.862 rs7786892 chr7:65628876 G/A cg12463550 chr7:65579703 CRCP -0.53 -7.49 -0.38 6.38e-13 Aortic root size; CRC cis rs116095464 0.558 rs10077076 chr5:231940 C/T cg22496380 chr5:211416 CCDC127 -0.88 -10.28 -0.49 1.1e-21 Breast cancer; CRC cis rs10992471 0.603 rs10116813 chr9:95090360 C/T cg14631576 chr9:95140430 CENPP -0.4 -6.99 -0.36 1.57e-11 Visceral adipose tissue/subcutaneous adipose tissue ratio; CRC cis rs6963495 0.818 rs55740553 chr7:105159551 A/G cg13798780 chr7:105162888 PUS7 0.68 8.08 0.41 1.27e-14 Bipolar disorder (body mass index interaction); CRC cis rs6570726 0.935 rs424263 chr6:145840073 A/C cg05347473 chr6:146136440 FBXO30 0.37 6.0 0.31 5.27e-9 Lobe attachment (rater-scored or self-reported); CRC trans rs2228479 0.850 rs11644213 chr16:89837367 C/T cg24644049 chr4:85504048 CDS1 -0.9 -7.61 -0.39 2.99e-13 Skin colour saturation; CRC cis rs2976388 0.609 rs2572899 chr8:143785549 A/G cg05569086 chr8:143859399 LYNX1 0.4 6.91 0.36 2.54e-11 Urinary tract infection frequency; CRC cis rs4843747 0.636 rs4075597 chr16:88107590 C/A cg07865391 chr16:88106882 BANP 0.47 5.94 0.31 7.09e-9 Menopause (age at onset); CRC cis rs1881797 1.000 rs12063141 chr1:247688343 G/A cg05639522 chr1:247681581 NA 0.51 7.43 0.38 9.57e-13 Acute lymphoblastic leukemia (childhood); CRC trans rs61931739 0.500 rs9795938 chr12:34587739 C/T cg26384229 chr12:38710491 ALG10B -0.61 -8.95 -0.44 2.57e-17 Morning vs. evening chronotype; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg17372494 chr2:27310078 KHK 0.43 6.46 0.34 3.68e-10 Intelligence (multi-trait analysis); CRC cis rs9527 0.640 rs6584541 chr10:104929124 A/G cg15744005 chr10:104629667 AS3MT -0.3 -5.97 -0.31 6.07e-9 Arsenic metabolism; CRC cis rs2354432 0.607 rs7545467 chr1:146746248 A/G cg25205988 chr1:146714368 CHD1L -1.13 -9.56 -0.47 2.83e-19 Mitochondrial DNA levels; CRC cis rs798554 0.679 rs7784066 chr7:2819727 T/A cg13628971 chr7:2884303 GNA12 0.54 7.91 0.4 4.06e-14 Height; CRC cis rs9640161 0.789 rs3735172 chr7:150028958 C/T cg13722127 chr7:150037890 RARRES2 -0.46 -7.97 -0.4 2.65e-14 Blood protein levels;Circulating chemerin levels; CRC cis rs354225 0.532 rs354211 chr2:54932516 C/T cg26097391 chr2:54893211 SPTBN1 0.43 6.83 0.35 4.01e-11 Schizophrenia; CRC cis rs34172651 0.517 rs11639856 chr16:24788645 A/T cg06028605 chr16:24865363 SLC5A11 -0.55 -8.71 -0.43 1.53e-16 Intelligence (multi-trait analysis); CRC cis rs9372498 0.505 rs17427284 chr6:118991953 A/T cg22561889 chr6:118971681 C6orf204 0.53 6.5 0.34 3.03e-10 Diastolic blood pressure; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg01348121 chr10:43633961 CSGALNACT2 0.47 6.56 0.34 2.13e-10 Anxiety disorder; CRC cis rs1018836 0.608 rs7821069 chr8:91465548 C/G cg16814680 chr8:91681699 NA -0.46 -7.13 -0.37 6.29e-12 Ejection fraction in Tripanosoma cruzi seropositivity; CRC cis rs7811142 1.000 rs11763414 chr7:100016844 C/G cg00814883 chr7:100076585 TSC22D4 -0.75 -9.48 -0.46 5.22e-19 Platelet count; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg10240496 chr7:29724441 LOC646762 0.42 6.09 0.32 3.12e-9 Intelligence (multi-trait analysis); CRC cis rs116095464 0.558 rs10057626 chr5:239720 T/G cg22857025 chr5:266934 NA -1.24 -16.67 -0.68 1.19e-45 Breast cancer; CRC cis rs4665809 1.000 rs6546768 chr2:26328800 A/G cg25036284 chr2:26402008 FAM59B -0.45 -5.86 -0.31 1.14e-8 Gut microbiome composition (summer); CRC cis rs10992471 0.603 rs11788523 chr9:95256593 G/A cg14631576 chr9:95140430 CENPP -0.39 -6.78 -0.35 5.43e-11 Visceral adipose tissue/subcutaneous adipose tissue ratio; CRC cis rs1552244 0.882 rs3755782 chr3:10029305 T/C cg13047869 chr3:10149882 C3orf24 0.51 6.91 0.36 2.54e-11 Alzheimer's disease; CRC cis rs10752881 0.839 rs6692207 chr1:183085304 T/C ch.1.3577855R chr1:183094577 LAMC1 0.89 15.86 0.66 1.84e-42 Colorectal cancer; CRC trans rs1814175 0.500 rs1825677 chr11:49233099 T/G cg03929089 chr4:120376271 NA -0.6 -8.81 -0.44 7.25e-17 Height; CRC cis rs17685 0.753 rs2302438 chr7:75677065 C/A cg16489192 chr7:75678113 MDH2;STYXL1 -0.35 -5.61 -0.3 4.25e-8 Coffee consumption;Coffee consumption (cups per day); CRC cis rs2011503 0.882 rs1064395 chr19:19361735 C/T cg11584989 chr19:19387371 SF4 0.47 5.97 0.31 6.14e-9 Bipolar disorder; CRC cis rs274567 0.602 rs272853 chr5:131688561 A/G cg18758796 chr5:131593413 PDLIM4 0.38 6.33 0.33 8.11e-10 Blood metabolite levels; CRC cis rs7772486 0.805 rs4896831 chr6:145959481 T/C cg05347473 chr6:146136440 FBXO30 0.37 5.69 0.3 2.77e-8 Lobe attachment (rater-scored or self-reported); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg26667821 chr1:155099774 EFNA1 0.41 6.04 0.32 4.18e-9 Intelligence (multi-trait analysis); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg20357023 chr2:178417605 TTC30B 0.49 6.89 0.36 2.77e-11 Response to antipsychotic treatment; CRC cis rs875971 0.660 rs801193 chr7:66030612 A/C cg00343986 chr7:65444356 GUSB -0.5 -7.49 -0.38 6.35e-13 Aortic root size; CRC cis rs4713118 0.527 rs4713151 chr6:28136356 G/A cg02683197 chr6:28174875 NA 0.87 10.73 0.51 3.25e-23 Parkinson's disease; CRC cis rs17826219 0.500 rs61685770 chr17:29085713 G/A cg13385521 chr17:29058706 SUZ12P 0.73 8.4 0.42 1.39e-15 Body mass index; CRC cis rs12594515 0.967 rs11854477 chr15:45998345 A/C cg01629716 chr15:45996671 NA 0.38 7.6 0.39 3.03e-13 Waist circumference;Weight; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg03888365 chr8:123792680 ZHX2 0.46 6.46 0.34 3.83e-10 Response to antipsychotic treatment; CRC trans rs7267979 0.780 rs6050679 chr20:25537827 A/T cg17903999 chr18:56338584 MALT1 -0.39 -6.44 -0.33 4.34e-10 Liver enzyme levels (alkaline phosphatase); CRC cis rs910316 0.737 rs175071 chr14:75498177 A/G cg03030879 chr14:75389066 RPS6KL1 0.45 7.16 0.37 5.18e-12 Height; CRC cis rs7264396 0.561 rs6060750 chr20:34596371 C/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.53 -8.4 -0.42 1.31e-15 Total cholesterol levels; CRC cis rs13118159 0.801 rs13147602 chr4:1332175 A/G cg21620606 chr4:1342894 KIAA1530 0.51 8.72 0.43 1.44e-16 Longevity; CRC cis rs875971 0.520 rs2420597 chr7:65915986 A/G cg18252515 chr7:66147081 NA -0.4 -5.8 -0.3 1.57e-8 Aortic root size; CRC cis rs1552244 0.554 rs55847233 chr3:9991101 C/G cg18598329 chr3:10140678 FANCD2;C3orf24 -0.59 -9.08 -0.45 9.9e-18 Alzheimer's disease; CRC cis rs2153535 0.580 rs4960422 chr6:8459309 T/C cg21535247 chr6:8435926 SLC35B3 0.51 7.9 0.4 4.36e-14 Motion sickness; CRC cis rs10089 1.000 rs1560636 chr5:127447987 A/G cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.76 10.77 0.51 2.25e-23 Ileal carcinoids; CRC trans rs9291683 0.597 rs11722989 chr4:10126139 A/G cg26043149 chr18:55253948 FECH -0.56 -8.72 -0.43 1.42e-16 Bone mineral density; CRC cis rs9393692 0.905 rs7747133 chr6:26293470 C/T cg13736514 chr6:26305472 NA -0.62 -11.66 -0.54 1.56e-26 Educational attainment; CRC cis rs7208859 0.623 rs1061346 chr17:29114229 G/A cg01831904 chr17:28903510 LRRC37B2 -0.62 -6.41 -0.33 5.13e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs10788264 0.504 rs1034533 chr10:124032434 A/G cg05683857 chr10:124030795 BTBD16 0.32 5.71 0.3 2.51e-8 Total body bone mineral density; CRC cis rs2228479 0.850 rs2283565 chr16:89827556 G/T cg06558623 chr16:89946397 TCF25 1.13 10.45 0.5 2.85e-22 Skin colour saturation; CRC cis rs12220238 0.908 rs10824077 chr10:75887038 C/T cg19889307 chr10:75911429 ADK;AP3M1 -0.57 -5.7 -0.3 2.64e-8 Soluble interleukin-2 receptor subunit alpha; CRC cis rs12410462 0.581 rs112572966 chr1:227553905 C/T cg23173402 chr1:227635558 NA 0.59 5.99 0.31 5.54e-9 Major depressive disorder; CRC cis rs2739330 0.789 rs5760109 chr22:24252938 C/G cg16132339 chr22:24313637 DDTL;DDT 0.61 9.93 0.48 1.68e-20 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs12580194 0.593 rs61957933 chr12:55744710 T/G cg19537932 chr12:55886519 OR6C68 -0.66 -8.56 -0.43 4.26e-16 Cancer; CRC cis rs514406 0.861 rs11206011 chr1:53235910 T/C cg27535305 chr1:53392650 SCP2 0.38 7.27 0.37 2.64e-12 Monocyte count; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg01399255 chr7:100271274 GNB2 -0.41 -6.09 -0.32 3.22e-9 Myopia (pathological); CRC cis rs77972916 0.609 rs13414381 chr2:43567218 A/G cg06169590 chr2:43455088 ZFP36L2;LOC100129726 -0.56 -5.67 -0.3 3.08e-8 Granulocyte percentage of myeloid white cells; CRC cis rs11212617 0.935 rs227055 chr11:108261261 G/A cg14761454 chr11:108092087 ATM;NPAT 0.41 6.04 0.32 4.09e-9 Response to metformin in type 2 diabetes (glycemic); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg08833169 chr11:810149 RPLP2 0.37 6.29 0.33 1.02e-9 Liver disease severity in Alagille syndrome; CRC trans rs11148252 0.875 rs4884452 chr13:52949784 C/T cg18335740 chr13:41363409 SLC25A15 -0.49 -7.69 -0.39 1.73e-13 Lewy body disease; CRC cis rs7666738 0.830 rs17027058 chr4:98864671 G/A cg17366294 chr4:99064904 C4orf37 0.41 6.83 0.35 4.19e-11 Colonoscopy-negative controls vs population controls; CRC cis rs10504229 0.861 rs116964504 chr8:58185354 A/C cg24829409 chr8:58192753 C8orf71 -0.68 -11.34 -0.53 2.27e-25 Developmental language disorder (linguistic errors); CRC cis rs4728302 0.869 rs7805864 chr7:133610390 G/A cg03336402 chr7:133662267 EXOC4 -0.44 -6.35 -0.33 7.32e-10 Intelligence;Intelligence (multi-trait analysis); CRC trans rs12599106 0.648 rs12447240 chr16:34928236 C/T cg03395511 chr6:291903 DUSP22 0.64 9.04 0.45 1.38e-17 Menopause (age at onset); CRC cis rs4363385 0.818 rs12029168 chr1:152987993 G/A cg25856811 chr1:152973957 SPRR3 -0.25 -7.1 -0.36 7.82e-12 Inflammatory skin disease; CRC cis rs9435341 0.762 rs72697623 chr1:107554269 G/A cg14828511 chr1:107599125 PRMT6 0.48 6.58 0.34 1.86e-10 Facial morphology (factor 21, depth of nasal alae); CRC cis rs17881320 0.510 rs7221385 chr17:40562081 C/T cg05878104 chr17:40932452 WNK4 -0.56 -6.8 -0.35 4.82e-11 Atopic dermatitis; CRC cis rs6546550 0.935 rs13017134 chr2:70090579 C/G cg02498382 chr2:70120550 SNRNP27 -0.4 -6.44 -0.33 4.15e-10 Prevalent atrial fibrillation; CRC cis rs2033711 0.503 rs6510141 chr19:58885786 C/G cg00825309 chr19:58991885 ZNF446 0.41 5.91 0.31 8.32e-9 Uric acid clearance; CRC cis rs7043114 0.525 rs710162 chr9:95059790 A/T cg14631576 chr9:95140430 CENPP 0.34 6.48 0.34 3.3e-10 Height; CRC cis rs7772486 0.754 rs6937661 chr6:146113299 T/C cg05347473 chr6:146136440 FBXO30 -0.38 -5.72 -0.3 2.36e-8 Lobe attachment (rater-scored or self-reported); CRC cis rs637571 0.528 rs566266 chr11:65573587 A/C cg26695010 chr11:65641043 EFEMP2 0.48 7.46 0.38 7.59e-13 Eosinophil percentage of white cells; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg07921184 chr16:71880281 ATXN1L 0.44 6.53 0.34 2.43e-10 Intelligence (multi-trait analysis); CRC cis rs270601 0.913 rs273916 chr5:131659830 C/A cg09877947 chr5:131593287 PDLIM4 0.44 7.15 0.37 5.73e-12 Acylcarnitine levels; CRC cis rs9549367 0.789 rs2287244 chr13:113887173 C/G cg24300038 chr13:113819356 PROZ 0.44 6.07 0.32 3.51e-9 Platelet distribution width; CRC cis rs2361710 0.668 rs4889830 chr17:78114528 G/A cg20811857 chr17:78079795 GAA -0.41 -6.54 -0.34 2.33e-10 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count;Immature fraction of reticulocytes; CRC cis rs9527 0.615 rs7899622 chr10:104727333 C/T cg15744005 chr10:104629667 AS3MT -0.31 -6.18 -0.32 1.85e-9 Arsenic metabolism; CRC cis rs2576037 0.526 rs1893427 chr18:44434987 C/T cg19077165 chr18:44547161 KATNAL2 -0.58 -9.69 -0.47 1.08e-19 Personality dimensions; CRC cis rs7223966 1.000 rs17549954 chr17:61707032 A/G cg23090583 chr17:61904693 PSMC5;FTSJ3 0.53 6.44 0.33 4.23e-10 Hip circumference adjusted for BMI;Body mass index; CRC cis rs791888 0.965 rs791875 chr10:89406088 C/T cg13926569 chr10:89418898 PAPSS2 -0.44 -6.49 -0.34 3.15e-10 Magnesium levels; CRC cis rs4665809 0.590 rs10495756 chr2:26485586 A/G cg04944784 chr2:26401820 FAM59B 0.85 11.05 0.52 2.29e-24 Gut microbiome composition (summer); CRC cis rs6952808 1.000 rs6957894 chr7:1887362 G/A cg02951883 chr7:2050386 MAD1L1 -0.64 -10.33 -0.5 7.3e-22 Bipolar disorder and schizophrenia; CRC cis rs8070740 0.898 rs9895440 chr17:5325643 C/A cg25236894 chr17:5323110 RPAIN;NUP88 0.48 7.5 0.38 5.95e-13 Menopause (age at onset); CRC cis rs11098499 0.863 rs3775844 chr4:120428033 G/A cg09307838 chr4:120376055 NA 0.68 10.3 0.49 9.17e-22 Corneal astigmatism; CRC cis rs6964587 1.000 rs7781066 chr7:91691946 G/T cg17063962 chr7:91808500 NA 0.78 13.83 0.61 1.29e-34 Breast cancer; CRC cis rs853679 0.517 rs6932109 chr6:28078303 A/G cg12273811 chr6:28175739 NA -0.7 -9.27 -0.46 2.52e-18 Depression; CRC cis rs12760731 0.565 rs7536856 chr1:178057927 A/G cg00404053 chr1:178313656 RASAL2 0.95 9.89 0.48 2.32e-20 Obesity-related traits; CRC cis rs6952808 0.531 rs73039217 chr7:2178731 G/A cg04267008 chr7:1944627 MAD1L1 -0.62 -8.4 -0.42 1.37e-15 Bipolar disorder and schizophrenia; CRC cis rs589448 0.933 rs2249093 chr12:69753512 G/C cg22834771 chr12:69754056 YEATS4 -0.56 -8.73 -0.43 1.33e-16 Cerebrospinal fluid biomarker levels; CRC trans rs561341 0.941 rs4795664 chr17:30233467 C/T cg27661571 chr11:113659931 NA -0.67 -7.6 -0.39 3.07e-13 Hip circumference adjusted for BMI; CRC cis rs2735413 0.881 rs12923218 chr16:78080274 C/G cg04733911 chr16:78082701 NA -0.44 -7.37 -0.38 1.38e-12 Systolic blood pressure (alcohol consumption interaction); CRC cis rs875971 1.000 rs6979382 chr7:65886375 C/T cg18912574 chr7:65842487 NCRNA00174 0.35 6.04 0.32 4.23e-9 Aortic root size; CRC cis rs28386778 0.897 rs2665795 chr17:61925272 A/G cg25654072 chr17:61904446 PSMC5;FTSJ3 -0.69 -10.73 -0.51 3.06e-23 Prudent dietary pattern; CRC cis rs8014204 1.000 rs10483863 chr14:75322327 A/G cg03030879 chr14:75389066 RPS6KL1 0.55 9.14 0.45 6.51e-18 Caffeine consumption; CRC cis rs6951245 0.706 rs28522260 chr7:1183964 C/A cg24642844 chr7:1081250 C7orf50 -0.68 -8.38 -0.42 1.57e-15 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs911119 0.818 rs67862677 chr20:23591086 A/C cg16589663 chr20:23618590 CST3 0.59 7.49 0.38 6.55e-13 Chronic kidney disease; CRC cis rs763121 0.853 rs5750630 chr22:38985818 A/C cg06022373 chr22:39101656 GTPBP1 0.75 11.07 0.52 1.97e-24 Menopause (age at onset); CRC cis rs6834538 0.965 rs1580476 chr4:113493365 A/G cg10021238 chr4:113569128 MIR367;LARP7 -0.46 -6.48 -0.34 3.35e-10 Free thyroxine concentration; CRC cis rs3741404 0.620 rs2236647 chr11:63964605 A/G cg18225595 chr11:63971243 STIP1 -0.49 -7.98 -0.4 2.5e-14 Platelet count; CRC cis rs9487051 0.773 rs351749 chr6:109533353 A/T cg01475377 chr6:109611718 NA -0.34 -5.9 -0.31 9.23e-9 Reticulocyte fraction of red cells; CRC cis rs698833 0.892 rs1067371 chr2:44651982 A/G cg04920474 chr2:44395004 PPM1B 0.41 6.07 0.32 3.61e-9 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; CRC trans rs5756813 0.754 rs5750495 chr22:38179120 T/A cg19894588 chr14:64061835 NA 0.55 7.43 0.38 9.35e-13 Optic cup area;Vertical cup-disc ratio; CRC cis rs6582630 0.502 rs10880092 chr12:38262965 A/T cg26384229 chr12:38710491 ALG10B 0.69 9.22 0.45 3.69e-18 Drug-induced liver injury (flucloxacillin); CRC cis rs992157 0.710 rs12694432 chr2:219082330 A/G cg04731861 chr2:219085781 ARPC2 -0.31 -6.52 -0.34 2.57e-10 Colorectal cancer; CRC cis rs4713118 0.591 rs2056924 chr6:27690174 G/A cg06470822 chr6:28175283 NA 0.63 9.06 0.45 1.19e-17 Parkinson's disease; CRC cis rs7539624 0.541 rs6674733 chr1:223906397 A/G cg10100437 chr1:223903862 CAPN2 0.41 5.87 0.31 1.09e-8 Schizophrenia; CRC cis rs3008870 1.000 rs3008874 chr1:67431365 A/T cg08660285 chr1:67390436 MIER1;WDR78 1.03 15.22 0.64 5.89e-40 Lymphocyte percentage of white cells; CRC cis rs7914558 1.000 rs11191539 chr10:104819770 A/G cg04362960 chr10:104952993 NT5C2 0.6 9.04 0.45 1.38e-17 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC trans rs6678914 1.000 rs12131882 chr1:202188264 A/G cg19977628 chr5:1262072 TERT 0.41 6.13 0.32 2.54e-9 Breast cancer (estrogen-receptor negative);Breast cancer; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg08496016 chr9:99181722 ZNF367 0.45 6.27 0.33 1.14e-9 Response to antipsychotic treatment; CRC trans rs2018683 0.707 rs1021691 chr7:28974496 C/T cg19402173 chr7:128379420 CALU -0.43 -6.3 -0.33 9.74e-10 Response to irinotecan and platinum-based chemotherapy in non-small-cell lung cancer; CRC cis rs2637266 0.600 rs11001843 chr10:78401949 T/A cg18941641 chr10:78392320 NA -0.38 -6.46 -0.34 3.78e-10 Pulmonary function; CRC cis rs2239547 0.618 rs4687658 chr3:52860366 C/G cg18404041 chr3:52824283 ITIH1 -0.41 -7.65 -0.39 2.25e-13 Schizophrenia; CRC cis rs514406 0.861 rs2065477 chr1:53250213 C/T cg25767906 chr1:53392781 SCP2 -0.44 -6.81 -0.35 4.63e-11 Monocyte count; CRC cis rs1697139 0.563 rs6859520 chr5:66529020 C/T cg16691251 chr5:66510806 NA 0.46 8.13 0.41 9.07e-15 Breast cancer; CRC cis rs344364 0.511 rs1742467 chr16:1950187 G/T cg14074117 chr16:1909714 C16orf73 0.41 5.66 0.3 3.28e-8 Glomerular filtration rate in chronic kidney disease; CRC cis rs6921919 0.638 rs2108926 chr6:28308747 A/T cg03623178 chr6:28175578 NA 0.45 6.04 0.32 4.21e-9 Autism spectrum disorder or schizophrenia; CRC cis rs11608355 0.515 rs12833054 chr12:109890955 G/A cg05360138 chr12:110035743 NA 0.67 6.61 0.34 1.57e-10 Neuroticism; CRC trans rs7267979 0.932 rs6115215 chr20:25562500 C/T cg17903999 chr18:56338584 MALT1 -0.43 -6.99 -0.36 1.49e-11 Liver enzyme levels (alkaline phosphatase); CRC cis rs861020 0.563 rs35898529 chr1:210053096 G/A cg05527609 chr1:210001259 C1orf107 -0.92 -10.57 -0.5 1.08e-22 Orofacial clefts; CRC trans rs875971 0.660 rs2191268 chr7:66110224 C/T cg26708280 chr2:190649305 PMS1;ORMDL1 -0.4 -6.02 -0.31 4.66e-9 Aortic root size; CRC cis rs2073300 0.609 rs6132617 chr20:23420151 G/C cg12062639 chr20:23401060 NAPB 0.74 6.94 0.36 2.05e-11 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs6831352 0.879 rs2851255 chr4:100042103 C/G cg13256891 chr4:100009986 ADH5 0.65 8.73 0.43 1.35e-16 Alcohol dependence; CRC cis rs2832191 0.967 rs2832216 chr21:30521921 C/T cg08807101 chr21:30365312 RNF160 0.61 9.78 0.47 5.57e-20 Dental caries; CRC cis rs7605827 0.897 rs11675604 chr2:15672901 C/T cg19274914 chr2:15703543 NA 0.37 5.7 0.3 2.62e-8 Educational attainment (years of education); CRC cis rs9300255 0.596 rs1727331 chr12:123718879 C/G cg00376283 chr12:123451042 ABCB9 -0.59 -8.08 -0.41 1.24e-14 Neutrophil percentage of white cells; CRC cis rs2243480 1.000 rs57057549 chr7:65405738 A/G cg18252515 chr7:66147081 NA -1.08 -12.32 -0.56 5.94e-29 Diabetic kidney disease; CRC cis rs67311347 1.000 rs2168111 chr3:40395325 T/G cg24209194 chr3:40518798 ZNF619 0.42 6.5 0.34 2.97e-10 Renal cell carcinoma; CRC cis rs6499255 0.951 rs76407217 chr16:69690355 A/T cg15192750 chr16:69999425 NA 0.55 7.48 0.38 6.96e-13 IgE levels; CRC cis rs2745967 0.715 rs2724367 chr1:208067329 C/T cg09788693 chr1:208063733 CD34 0.46 6.99 0.36 1.58e-11 Resting heart rate; CRC cis rs9467711 0.559 rs13208916 chr6:26601940 G/A cg16898833 chr6:26189333 HIST1H4D 0.86 7.12 0.37 6.73e-12 Autism spectrum disorder or schizophrenia; CRC trans rs925098 0.577 rs2724470 chr4:17996046 A/G cg20982606 chr12:109535391 UNG -0.46 -6.88 -0.35 2.99e-11 Birth weight;Height; CRC cis rs11997175 0.624 rs4593494 chr8:33692621 C/T ch.8.33884649F chr8:33765107 NA 0.43 5.67 0.3 3.15e-8 Body mass index; CRC trans rs2832077 0.943 rs2832106 chr21:30191767 A/G cg14791747 chr16:20752902 THUMPD1 0.52 6.36 0.33 6.59e-10 Cognitive test performance; CRC cis rs7680126 0.672 rs10939819 chr4:10290661 T/C cg11266682 chr4:10021025 SLC2A9 -0.39 -6.02 -0.31 4.72e-9 Urate levels in lean individuals;Urate levels in overweight individuals;Urate levels in obese individuals; CRC cis rs1129187 0.686 rs6458313 chr6:42922018 A/G cg10862848 chr6:42927986 GNMT -0.38 -8.92 -0.44 3.21e-17 Alzheimer's disease in APOE e4+ carriers; CRC cis rs651907 0.557 rs56291106 chr3:101377474 C/T cg12386194 chr3:101231763 SENP7 0.49 7.11 0.36 7.34e-12 Colorectal cancer; CRC cis rs501120 0.584 rs11238911 chr10:44695862 A/G cg09554077 chr10:44749378 NA -0.66 -7.34 -0.38 1.71e-12 Coronary artery disease;Coronary heart disease; CRC cis rs2019137 0.539 rs4849177 chr2:113982584 T/C cg17445212 chr2:113993313 PAX8;LOC440839;LOC654433 0.47 7.21 0.37 3.99e-12 Lymphocyte counts; CRC cis rs7666738 0.830 rs7687958 chr4:99014495 T/C cg05340658 chr4:99064831 C4orf37 0.62 9.64 0.47 1.5700000000000001e-19 Colonoscopy-negative controls vs population controls; CRC cis rs651907 0.557 rs59596156 chr3:101394217 C/T cg12386194 chr3:101231763 SENP7 0.49 7.01 0.36 1.39e-11 Colorectal cancer; CRC cis rs13108904 0.846 rs4974574 chr4:1224811 A/G cg05665937 chr4:1216051 CTBP1 0.46 6.96 0.36 1.9e-11 Obesity-related traits; CRC cis rs9517313 0.591 rs17574543 chr13:99172893 G/A cg20487152 chr13:99095054 FARP1 -0.46 -6.5 -0.34 2.92e-10 Neuroticism; CRC cis rs870825 0.550 rs35981185 chr4:185639720 A/C cg04058563 chr4:185651563 MLF1IP 0.73 9.41 0.46 9.01e-19 Blood protein levels; CRC cis rs1865760 0.602 rs2157050 chr6:26020431 C/T cg18357526 chr6:26021779 HIST1H4A 0.45 6.38 0.33 6.12e-10 Height; CRC trans rs1455244 0.700 rs7229302 chr18:11508904 G/T cg19199531 chr22:20104664 TRMT2A;RANBP1 0.37 5.99 0.31 5.58e-9 Schizophrenia; CRC cis rs8180040 0.966 rs13059519 chr3:47539969 C/T cg10298567 chr3:47292165 KIF9 -0.36 -5.83 -0.31 1.31e-8 Colorectal cancer; CRC cis rs1355223 0.506 rs11032894 chr11:34865544 T/C cg11058730 chr11:34937778 PDHX;APIP -0.43 -6.07 -0.32 3.52e-9 Systemic lupus erythematosus and Systemic sclerosis; CRC cis rs801193 0.742 rs9969300 chr7:65781646 G/A cg11764359 chr7:65958608 NA -0.46 -7.14 -0.37 6.02e-12 Aortic root size; CRC cis rs7618915 0.570 rs2336145 chr3:52629750 A/C cg08222913 chr3:52553049 STAB1 -0.34 -6.16 -0.32 2.13e-9 Bipolar disorder; CRC cis rs2228479 0.867 rs62052189 chr16:89975555 G/C cg19635926 chr16:89946313 TCF25 0.53 5.72 0.3 2.42e-8 Skin colour saturation; CRC cis rs61612642 0.537 rs73434275 chr6:42156239 G/A cg10382835 chr6:42185730 MRPS10 0.74 7.07 0.36 9.07e-12 Eosinophil percentage of white cells;Sum eosinophil basophil counts;Eosinophil percentage of granulocytes;Eosinophil counts; CRC cis rs7512552 0.809 rs828783 chr1:150376977 C/T cg15654264 chr1:150340011 RPRD2 0.61 8.49 0.42 7.33e-16 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); CRC trans rs9858542 0.953 rs11719996 chr3:49525958 T/C cg21665057 chr3:196295764 WDR53;FBXO45 -0.65 -8.86 -0.44 5.12e-17 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs9928842 1.000 rs9928842 chr16:75242867 T/C cg09066997 chr16:75300724 BCAR1 0.69 6.59 0.34 1.74e-10 Alcoholic chronic pancreatitis; CRC cis rs6988985 0.533 rs6391 chr8:143956965 A/G cg10324643 chr8:143916377 GML 0.4 6.62 0.34 1.46e-10 Plasma androstenedione levels in resected early stage-receptor positive breast cancer; CRC cis rs172166 0.611 rs203882 chr6:28078502 G/A cg23161317 chr6:28129485 ZNF389 0.47 6.62 0.34 1.48e-10 Cardiac Troponin-T levels; CRC cis rs11212617 0.870 rs227063 chr11:108207304 T/G cg01991180 chr11:108092276 ATM;NPAT 0.43 6.37 0.33 6.29e-10 Response to metformin in type 2 diabetes (glycemic); CRC cis rs7224685 0.648 rs12453576 chr17:3881293 C/T cg09695851 chr17:3907499 NA 0.47 5.62 0.3 4.09e-8 Type 2 diabetes; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg06438056 chr1:33502433 AK2 0.44 6.49 0.34 3.17e-10 Liver disease severity in Alagille syndrome; CRC cis rs854765 0.505 rs4924832 chr17:17897739 A/G cg04398451 chr17:18023971 MYO15A -0.63 -11.88 -0.55 2.44e-27 Total body bone mineral density; CRC cis rs1127311 0.905 rs6699729 chr1:154582896 A/T cg24304309 chr1:154577895 ADAR 0.36 6.0 0.31 5.3e-9 C-reactive protein levels or triglyceride levels (pleiotropy); CRC cis rs7932354 0.528 rs11039097 chr11:47131881 C/T cg03339077 chr11:47165057 C11orf49 0.43 5.86 0.31 1.13e-8 Bone mineral density (hip);Bone mineral density; CRC cis rs896854 0.608 rs6991067 chr8:95875676 A/G cg13393036 chr8:95962371 TP53INP1 -0.47 -7.73 -0.39 1.34e-13 Type 2 diabetes; CRC cis rs769267 0.930 rs7254748 chr19:19397479 A/C cg17414380 chr19:19431394 KIAA0892;SF4 0.41 5.64 0.3 3.59e-8 Tonsillectomy; CRC cis rs2289681 0.525 rs2277617 chr17:42977073 T/G cg15193461 chr17:42977049 CCDC103;EFTUD2 -0.46 -5.81 -0.31 1.45e-8 Cognitive function; CRC cis rs1129187 0.686 rs6458313 chr6:42922018 A/G cg03790207 chr6:42947109 PEX6 -0.49 -6.92 -0.36 2.3e-11 Alzheimer's disease in APOE e4+ carriers; CRC trans rs7267979 1.000 rs7020 chr20:25278600 G/A cg17903999 chr18:56338584 MALT1 -0.42 -6.82 -0.35 4.36e-11 Liver enzyme levels (alkaline phosphatase); CRC cis rs360798 0.512 rs11893131 chr2:63079528 C/A cg17519650 chr2:63277830 OTX1 0.44 6.29 0.33 1.01e-9 Coronary artery disease; CRC cis rs6952808 0.609 rs4721190 chr7:1954732 A/G cg20295408 chr7:1910781 MAD1L1 0.4 5.9 0.31 8.9e-9 Bipolar disorder and schizophrenia; CRC cis rs9381040 0.655 rs9381031 chr6:41044957 A/T cg04346459 chr6:41068666 NFYA;LOC221442 -0.4 -5.82 -0.31 1.43e-8 Alzheimer's disease (late onset); CRC cis rs12618769 0.652 rs2276603 chr2:99205962 C/T cg18455616 chr2:99124870 INPP4A -0.35 -5.66 -0.3 3.25e-8 Bipolar disorder; CRC cis rs9467711 0.606 rs9393706 chr6:26361500 G/A cg16898833 chr6:26189333 HIST1H4D 0.75 6.55 0.34 2.26e-10 Autism spectrum disorder or schizophrenia; CRC cis rs11122272 0.735 rs2572249 chr1:231514829 G/A cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.52 -7.82 -0.4 7.45e-14 Hemoglobin concentration; CRC cis rs13256369 1.000 rs10088439 chr8:8576699 T/G cg06636001 chr8:8085503 FLJ10661 0.44 5.63 0.3 3.8e-8 Obesity-related traits; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg24965984 chr10:113943723 GPAM 0.45 6.14 0.32 2.36e-9 Response to antipsychotic treatment; CRC cis rs4689592 0.523 rs6446565 chr4:7074027 A/G cg06697600 chr4:7070879 GRPEL1 -0.48 -7.17 -0.37 4.89e-12 Monocyte percentage of white cells; CRC cis rs8077889 1.000 rs4793035 chr17:41887753 C/T cg25876840 chr17:41920477 NA 0.58 7.93 0.4 3.39e-14 Triglycerides; CRC trans rs11088226 1.000 rs2833890 chr21:33927886 A/G cg09050820 chr6:167586206 TCP10L2 -0.57 -6.44 -0.33 4.31e-10 Gastritis; CRC cis rs7408868 1.000 rs4809029 chr19:15273248 A/C cg14696996 chr19:15285081 NOTCH3 0.97 9.0 0.44 1.78e-17 Pulse pressure; CRC cis rs10046574 0.731 rs10270842 chr7:135163062 A/G cg27474649 chr7:135195673 CNOT4 0.66 5.83 0.31 1.32e-8 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs1059312 0.808 rs10847693 chr12:129292006 G/A cg21616243 chr12:129299702 MGC16384;SLC15A4 -0.75 -13.36 -0.59 8.31e-33 Systemic lupus erythematosus; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg14007442 chr17:46048497 CDK5RAP3 0.49 6.92 0.36 2.36e-11 Response to antipsychotic treatment; CRC cis rs1218582 0.711 rs4845677 chr1:154838050 C/T cg16680214 chr1:154839983 KCNN3 -0.49 -10.03 -0.48 7.96e-21 Prostate cancer; CRC cis rs6840360 0.548 rs4254751 chr4:152322571 C/T cg09659197 chr4:152720779 NA 0.33 6.29 0.33 1.04e-9 Intelligence (multi-trait analysis); CRC cis rs11711311 0.955 rs7650764 chr3:113414439 A/G cg15478005 chr3:113465772 ATP6V1A;NAA50 0.41 5.75 0.3 2.01e-8 IgG glycosylation; CRC cis rs10504229 1.000 rs17805656 chr8:58180318 T/C cg02725872 chr8:58115012 NA -0.38 -6.43 -0.33 4.44e-10 Developmental language disorder (linguistic errors); CRC cis rs79976124 0.800 rs12194767 chr6:66639599 A/G cg07460842 chr6:66804631 NA 0.67 7.86 0.4 5.51e-14 Type 2 diabetes; CRC cis rs1691799 0.899 rs1168306 chr12:66738900 A/G cg16791601 chr12:66731901 HELB -0.66 -10.92 -0.52 6.61e-24 White blood cell count (basophil); CRC cis rs1915146 0.546 rs1715862 chr10:126856255 C/T cg23000734 chr10:126850823 CTBP2 -0.56 -8.13 -0.41 8.58e-15 Menarche (age at onset); CRC cis rs2354432 0.556 rs2883319 chr1:146838177 A/G cg25205988 chr1:146714368 CHD1L -1.25 -10.12 -0.49 4.01e-21 Mitochondrial DNA levels; CRC cis rs8060686 0.641 rs55790290 chr16:68180242 A/G cg26727032 chr16:67993705 SLC12A4 -0.53 -6.25 -0.33 1.27e-9 HDL cholesterol;Metabolic syndrome; CRC cis rs10504073 0.584 rs7818507 chr8:49918423 G/T cg00325661 chr8:49890786 NA 0.6 10.84 0.51 1.3e-23 Blood metabolite ratios; CRC cis rs2075371 1.000 rs2075371 chr7:133984127 A/G cg02659138 chr7:134003124 SLC35B4 0.4 6.97 0.36 1.75e-11 Mean platelet volume; CRC cis rs990171 0.913 rs4851587 chr2:103073474 C/T cg03938978 chr2:103052716 IL18RAP 0.46 5.89 0.31 9.34e-9 Lymphocyte counts; CRC cis rs11148252 0.508 rs6561671 chr13:53182314 G/A cg12458913 chr13:53173898 NA 0.76 13.74 0.6 2.81e-34 Lewy body disease; CRC cis rs7107174 1.000 rs2510048 chr11:77987464 T/C cg02023728 chr11:77925099 USP35 0.51 7.42 0.38 1e-12 Testicular germ cell tumor; CRC cis rs10242455 1.000 rs73395547 chr7:98922746 C/A cg18809830 chr7:99032528 PTCD1 -0.75 -6.52 -0.34 2.65e-10 Blood metabolite levels; CRC cis rs12946454 0.668 rs4792867 chr17:43249444 C/T cg10701640 chr17:43249399 NA 0.5 11.79 0.55 5.11e-27 Systolic blood pressure; CRC cis rs6951245 1.000 rs77760339 chr7:1083927 G/T cg18402987 chr7:1209562 NA 0.64 6.78 0.35 5.48e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs968567 0.638 rs7943728 chr11:61547068 G/A cg19610905 chr11:61596333 FADS2 -0.63 -7.77 -0.39 1e-13 Blood metabolite levels;Rheumatoid arthritis;Vitiligo;Glycerophospholipid levels; CRC cis rs875971 0.862 rs2420173 chr7:65645399 A/T cg11764359 chr7:65958608 NA -0.6 -9.4 -0.46 9.21e-19 Aortic root size; CRC cis rs12497850 0.897 rs6795025 chr3:49081247 T/C cg20833759 chr3:49053208 WDR6;DALRD3 0.54 9.33 0.46 1.67e-18 Parkinson's disease; CRC cis rs8062405 0.824 rs62034324 chr16:28536762 T/C cg16576597 chr16:28551801 NUPR1 0.47 7.34 0.37 1.74e-12 Cognitive ability (multi-trait analysis);Cognitive ability; CRC cis rs2398893 0.774 rs35271736 chr9:96888786 A/G cg14459158 chr9:96720562 NA 0.44 6.28 0.33 1.04e-9 Waist-hip ratio;Waist-to-hip ratio adjusted for body mass index; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg22611817 chr5:60628016 ZSWIM6 0.44 5.97 0.31 6.05e-9 Anxiety disorder; CRC cis rs1862618 0.853 rs866222 chr5:56184444 T/C cg03609598 chr5:56110824 MAP3K1 -0.85 -10.06 -0.49 6.18e-21 Initial pursuit acceleration; CRC cis rs9976767 0.608 rs11909987 chr21:43822402 C/A cg23042151 chr21:43824109 UBASH3A -0.4 -6.69 -0.35 9.5e-11 Type 1 diabetes; CRC cis rs2637266 0.538 rs11510986 chr10:78415171 C/T cg18941641 chr10:78392320 NA -0.34 -5.73 -0.3 2.32e-8 Pulmonary function; CRC cis rs2302190 0.882 rs6503859 chr17:56460852 C/G cg25885038 chr17:56607967 SEPT4 -0.37 -5.74 -0.3 2.15e-8 Vitamin D levels; CRC cis rs375066 0.585 rs2195981 chr19:44352971 T/C cg19542119 chr19:44331823 ZNF283 0.4 5.61 0.3 4.24e-8 Breast cancer; CRC cis rs9463078 0.625 rs1329710 chr6:44969125 T/C cg25276700 chr6:44698697 NA -0.25 -6.14 -0.32 2.33e-9 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; CRC cis rs853679 0.542 rs9380063 chr6:28137853 A/G cg02631126 chr6:28058918 ZSCAN12L1 0.29 5.91 0.31 8.38e-9 Depression; CRC cis rs4332037 0.713 rs56093134 chr7:1973970 C/T cg21155852 chr7:2048760 MAD1L1 -0.49 -6.51 -0.34 2.86e-10 Bipolar disorder; CRC trans rs6686842 0.965 rs2802566 chr1:41551981 A/G cg19787969 chr8:9763211 NA 0.29 6.13 0.32 2.57e-9 Height; CRC cis rs6582630 0.512 rs11181007 chr12:38266700 C/T cg13010199 chr12:38710504 ALG10B -0.41 -5.87 -0.31 1.07e-8 Drug-induced liver injury (flucloxacillin); CRC cis rs4731207 0.565 rs1994022 chr7:124580877 C/T cg23710748 chr7:124431027 NA -0.38 -6.09 -0.32 3.18e-9 Cutaneous malignant melanoma; CRC cis rs4481887 0.927 rs10749646 chr1:248429719 A/G cg00666640 chr1:248458726 OR2T12 -0.6 -10.6 -0.5 9.03e-23 Common traits (Other); CRC cis rs11583043 1.000 rs6700743 chr1:101447384 A/T cg16556008 chr1:101360663 SLC30A7;EXTL2 0.47 6.07 0.32 3.46e-9 Ulcerative colitis;Inflammatory bowel disease; CRC cis rs7552404 1.000 rs12091720 chr1:76186949 G/A cg10523679 chr1:76189770 ACADM 0.86 11.75 0.54 7.34e-27 Blood metabolite levels;Acylcarnitine levels; CRC cis rs12101261 0.556 rs2300516 chr14:81446908 A/G cg06600135 chr14:81408086 NA 0.39 5.68 0.3 3.01e-8 Graves' disease; CRC cis rs4969178 0.965 rs11653305 chr17:76386918 T/C cg05887092 chr17:76393375 PGS1 0.55 9.93 0.48 1.64e-20 HDL cholesterol levels; CRC cis rs6460942 0.908 rs59410610 chr7:12282847 A/G cg06484146 chr7:12443880 VWDE -0.62 -6.51 -0.34 2.79e-10 Coronary artery disease; CRC cis rs9311676 0.609 rs11921259 chr3:58368646 A/G cg06643156 chr3:58380774 PXK 0.41 6.35 0.33 7.2e-10 Systemic lupus erythematosus; CRC cis rs4481887 0.927 rs12042598 chr1:248482016 C/T cg13385794 chr1:248469461 NA 0.4 7.11 0.36 7.23e-12 Common traits (Other); CRC cis rs72945132 0.882 rs4261311 chr11:70132902 C/T cg00319359 chr11:70116639 PPFIA1 0.67 7.4 0.38 1.13e-12 Coronary artery disease; CRC cis rs9372498 0.536 rs9489428 chr6:118852935 T/C cg15382696 chr6:118971807 C6orf204 0.61 8.01 0.4 2.07e-14 Diastolic blood pressure; CRC cis rs9534288 0.577 rs7999168 chr13:46680264 A/C cg15192986 chr13:46630673 CPB2 -0.64 -8.59 -0.43 3.58e-16 Blood protein levels; CRC cis rs28386778 0.787 rs2665827 chr17:61961350 G/C cg06601766 chr17:61851465 DDX42;CCDC47 0.46 6.12 0.32 2.59e-9 Prudent dietary pattern; CRC cis rs3785574 0.962 rs16947051 chr17:61790917 G/C cg06873352 chr17:61820015 STRADA 0.49 7.91 0.4 3.85e-14 Height; CRC trans rs1656966 1.000 rs1656966 chr3:186466252 C/T cg07257037 chr12:70132348 RAB3IP 0.41 6.12 0.32 2.64e-9 Myopia (pathological); CRC cis rs9372498 0.536 rs9489394 chr6:118758234 T/C cg15382696 chr6:118971807 C6orf204 0.6 7.67 0.39 1.9e-13 Diastolic blood pressure; CRC cis rs2880765 0.743 rs6416598 chr15:86011848 G/A cg17133734 chr15:86042851 AKAP13 0.4 6.35 0.33 6.95e-10 Coronary artery disease; CRC cis rs35306767 0.855 rs12781100 chr10:838636 C/T cg20503657 chr10:835505 NA 1.29 15.43 0.65 8.96e-41 Eosinophil percentage of granulocytes; CRC cis rs1577917 0.816 rs9353349 chr6:86707725 T/A cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A 0.48 6.33 0.33 8.13e-10 Response to antipsychotic treatment; CRC cis rs909674 0.818 rs5757681 chr22:39845547 A/G cg25459000 chr22:39777742 SYNGR1 -0.32 -5.77 -0.3 1.83e-8 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; CRC cis rs2153535 0.560 rs2210798 chr6:8481522 C/T cg21535247 chr6:8435926 SLC35B3 0.5 7.51 0.38 5.54e-13 Motion sickness; CRC cis rs524281 0.861 rs11227415 chr11:65885459 C/T cg14036092 chr11:66035641 RAB1B 0.47 5.71 0.3 2.54e-8 Electroencephalogram traits; CRC cis rs9905704 0.671 rs4337355 chr17:56950920 C/T cg12560992 chr17:57184187 TRIM37 0.61 9.3 0.46 1.99e-18 Testicular germ cell tumor; CRC cis rs968567 0.528 rs174582 chr11:61607168 A/G cg00603274 chr11:61596626 FADS2 -0.64 -7.77 -0.39 9.87e-14 Blood metabolite levels;Rheumatoid arthritis;Vitiligo;Glycerophospholipid levels; CRC trans rs9650657 0.683 rs7005905 chr8:10585144 C/T cg06636001 chr8:8085503 FLJ10661 0.45 6.54 0.34 2.38e-10 Neuroticism; CRC cis rs7918232 0.825 rs4749233 chr10:27467967 G/A cg14240646 chr10:27532245 ACBD5 -0.86 -9.85 -0.48 3.16e-20 Breast cancer; CRC cis rs12479064 0.703 rs28382977 chr2:100018304 G/A cg26064155 chr2:99771622 LIPT1;TSGA10 -0.62 -7.75 -0.39 1.12e-13 Chronic sinus infection; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg07240673 chr16:3550908 CLUAP1 0.42 6.45 0.34 3.92e-10 Intelligence (multi-trait analysis); CRC cis rs478304 0.514 rs75601653 chr11:65483370 C/G cg05805236 chr11:65401703 PCNXL3 -0.4 -6.09 -0.32 3.1e-9 Acne (severe); CRC cis rs12760731 0.565 rs12732507 chr1:178098296 A/G cg00404053 chr1:178313656 RASAL2 1.1 11.41 0.53 1.2e-25 Obesity-related traits; CRC cis rs1552244 0.872 rs6803517 chr3:10065426 C/T cg02579736 chr3:10068473 FANCD2;CIDECP 0.95 12.63 0.57 4.38e-30 Alzheimer's disease; CRC cis rs853679 0.550 rs1150692 chr6:28173957 A/G cg23161317 chr6:28129485 ZNF389 0.45 5.92 0.31 8.13e-9 Depression; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg10251347 chr1:52344305 NRD1 0.46 6.57 0.34 1.94e-10 Response to antipsychotic treatment; CRC cis rs7927771 0.524 rs11039402 chr11:47826090 A/C cg20307385 chr11:47447363 PSMC3 0.46 6.64 0.34 1.33e-10 Subjective well-being; CRC cis rs10992471 0.756 rs2761681 chr9:95186937 A/G cg13798575 chr9:95087839 CENPP;NOL8 -0.48 -6.94 -0.36 2.04e-11 Visceral adipose tissue/subcutaneous adipose tissue ratio; CRC cis rs10883723 0.773 rs11191303 chr10:104255158 T/C cg11453585 chr10:104263688 ACTR1A;SUFU 0.92 17.58 0.7 2.89e-49 Allergic disease (asthma, hay fever or eczema); CRC cis rs7617773 0.784 rs9850672 chr3:48301172 C/A cg11946769 chr3:48343235 NME6 0.63 8.63 0.43 2.64e-16 Coronary artery disease; CRC cis rs8180040 1.000 rs553989 chr3:47400328 A/G cg10298567 chr3:47292165 KIF9 0.41 6.78 0.35 5.45e-11 Colorectal cancer; CRC cis rs3096299 0.967 rs3102341 chr16:89450744 G/A cg01788221 chr16:89496183 ANKRD11 -0.39 -5.75 -0.3 2.03e-8 Multiple myeloma (IgH translocation); CRC cis rs1005224 0.963 rs12887886 chr14:76167846 C/T cg04684003 chr14:76127793 TTLL5;C14orf1 -0.44 -6.29 -0.33 1e-9 Large artery stroke; CRC cis rs75422866 0.510 rs73105845 chr12:48135607 T/C cg14736327 chr12:48174669 SLC48A1 -0.84 -6.78 -0.35 5.63e-11 Pneumonia; CRC cis rs4988958 0.565 rs12712146 chr2:103008714 C/T cg03938978 chr2:103052716 IL18RAP 0.59 10.17 0.49 2.56e-21 Asthma (childhood onset); CRC cis rs9788721 0.836 rs17483548 chr15:78730313 G/A cg18825076 chr15:78729989 IREB2 -0.5 -7.35 -0.38 1.62e-12 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio;Emphysema imaging phenotypes;Emphysema distribution in smoking;Local histogram emphysema pattern;Post bronchodilator FEV1/FVC ratio in COPD; CRC trans rs1814175 0.645 rs1818895 chr11:50031523 G/T cg03929089 chr4:120376271 NA -0.89 -15.88 -0.66 1.45e-42 Height; CRC cis rs898097 0.812 rs56274787 chr17:80862682 C/T cg03160526 chr17:80928410 B3GNTL1 -0.4 -5.79 -0.3 1.68e-8 Breast cancer; CRC cis rs35146811 0.735 rs1727130 chr7:99811464 C/G cg13334819 chr7:99746414 C7orf59 0.51 6.71 0.35 8.67e-11 Coronary artery disease; CRC trans rs9784649 0.891 rs57355285 chr5:25016384 C/G cg11038491 chr20:34638489 LOC647979 -0.61 -7.28 -0.37 2.45e-12 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs9818758 0.607 rs34823813 chr3:49749976 G/A cg07636037 chr3:49044803 WDR6 -0.77 -5.64 -0.3 3.76e-8 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; CRC cis rs73206853 0.764 rs12311093 chr12:110978032 A/G cg12870014 chr12:110450643 ANKRD13A -0.83 -12.01 -0.55 8.5e-28 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC trans rs6076960 0.684 rs3909086 chr20:6251639 A/G cg17788362 chr6:86352627 SYNCRIP 0.48 6.46 0.34 3.69e-10 Smooth-surface caries; CRC cis rs864537 0.622 rs2949661 chr1:167424924 C/T cg22356347 chr1:167427500 CD247 -0.38 -5.7 -0.3 2.62e-8 Celiac disease or Rheumatoid arthritis;Celiac disease; CRC cis rs6424115 0.793 rs2502998 chr1:24198327 T/A cg10978503 chr1:24200527 CNR2 0.6 11.12 0.52 1.31e-24 Immature fraction of reticulocytes; CRC cis rs4561483 0.582 rs35063476 chr16:12044301 A/G cg08843971 chr16:11963173 GSPT1 -0.53 -7.02 -0.36 1.25e-11 Testicular germ cell tumor; CRC cis rs6951245 0.554 rs11761322 chr7:1151657 A/G cg22907277 chr7:1156413 C7orf50 0.82 10.64 0.51 6.26e-23 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs11864453 0.713 rs2241412 chr16:72144284 A/G cg01557791 chr16:72042693 DHODH -0.43 -6.08 -0.32 3.28e-9 Fibrinogen levels; CRC cis rs6951245 0.872 rs112309216 chr7:1100296 A/T cg26224354 chr7:1096374 C7orf50;GPR146 -0.93 -12.05 -0.55 5.9e-28 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs6502050 0.842 rs62079996 chr17:80076862 A/G cg19223190 chr17:80058835 NA -0.41 -6.56 -0.34 2.07e-10 Life satisfaction; CRC cis rs7264396 1.000 rs224415 chr20:34135629 G/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.44 -7.11 -0.36 7.42e-12 Total cholesterol levels; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg27266479 chr1:9294882 H6PD 0.46 7.19 0.37 4.4e-12 Liver disease severity in Alagille syndrome; CRC cis rs2050392 0.624 rs303450 chr10:30725337 C/A cg18806716 chr10:30721971 MAP3K8 -0.71 -10.23 -0.49 1.62e-21 Inflammatory bowel disease; CRC cis rs2228479 0.850 rs11644213 chr16:89837367 C/T cg19635926 chr16:89946313 TCF25 -0.61 -5.67 -0.3 3.07e-8 Skin colour saturation; CRC cis rs3087591 1.000 rs1800845 chr17:29703438 C/G cg24425628 chr17:29625626 OMG;NF1 -0.88 -16.73 -0.68 6.61e-46 Hip circumference; CRC cis rs6963495 0.818 rs73190163 chr7:105157294 G/T cg13798780 chr7:105162888 PUS7 0.68 8.08 0.41 1.27e-14 Bipolar disorder (body mass index interaction); CRC cis rs67340775 0.541 rs200974 chr6:27855845 A/G cg03623178 chr6:28175578 NA 0.88 9.15 0.45 6.03e-18 Lung cancer in ever smokers; CRC cis rs4727027 0.704 rs2269972 chr7:148914047 C/T cg23583168 chr7:148888333 NA 0.9 16.65 0.68 1.4e-45 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC cis rs10504229 1.000 rs112272435 chr8:58170371 A/G cg05313129 chr8:58192883 C8orf71 -0.47 -6.99 -0.36 1.49e-11 Developmental language disorder (linguistic errors); CRC cis rs12541635 0.677 rs62527405 chr8:107058109 G/C cg10147462 chr8:107024639 NA 0.6 10.5 0.5 2.01e-22 Age of smoking initiation; CRC cis rs11577318 0.853 rs17645 chr1:26646730 A/G cg00852783 chr1:26633632 UBXN11 0.48 6.77 0.35 5.83e-11 Granulocyte percentage of myeloid white cells; CRC trans rs208520 0.690 rs176289 chr6:66766522 C/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.04 -14.61 -0.63 1.29e-37 Exhaled nitric oxide output; CRC cis rs911186 0.730 rs2393911 chr6:27057079 C/T cg12292205 chr6:26970375 C6orf41 -0.64 -8.36 -0.42 1.83e-15 Autism spectrum disorder or schizophrenia; CRC cis rs6121246 0.909 rs7272062 chr20:30259145 A/G cg07809909 chr20:30433512 FOXS1 0.36 5.8 0.3 1.56e-8 Mean corpuscular hemoglobin; CRC cis rs9649213 0.593 rs6944262 chr7:97985415 T/G cg08684580 chr7:98029266 BAIAP2L1 -0.32 -5.67 -0.3 3.14e-8 Prostate cancer (SNP x SNP interaction); CRC cis rs4926298 1.000 rs11085829 chr19:13174312 G/A cg23899408 chr19:12877188 HOOK2 -0.46 -6.36 -0.33 6.73e-10 Bipolar disorder; CRC cis rs9768139 0.935 rs10949715 chr7:158117246 G/T cg06219351 chr7:158114137 PTPRN2 -0.47 -7.18 -0.37 4.56e-12 Calcium levels; CRC cis rs362296 0.511 rs2857861 chr4:3323767 C/T cg11522145 chr4:3412961 RGS12 -0.37 -6.32 -0.33 8.31e-10 Parental longevity (mother's age at death); CRC cis rs904251 0.797 rs1757181 chr6:37485728 A/G cg01843034 chr6:37503916 NA 0.44 8.44 0.42 1.01e-15 Cognitive performance; CRC cis rs78456975 1.000 rs13397299 chr2:1564222 A/C cg01028140 chr2:1542097 TPO -0.56 -5.82 -0.31 1.4e-8 Placebo response in major depressive disorder (% change in symptom score); CRC cis rs9457247 0.765 rs9459836 chr6:167419105 G/A cg07741184 chr6:167504864 NA 0.39 6.66 0.34 1.17e-10 Crohn's disease; CRC cis rs1953600 0.754 rs2573348 chr10:81925785 C/T cg00277334 chr10:82204260 NA -0.37 -5.96 -0.31 6.48e-9 Sarcoidosis; CRC cis rs10256972 0.567 rs2960835 chr7:1202963 A/G cg03923535 chr7:1197113 ZFAND2A 0.73 11.07 0.52 1.96e-24 Longevity;Endometriosis; CRC trans rs12797204 0.793 rs36110284 chr11:83451753 T/C cg07421806 chr5:128301136 SLC27A6 -0.6 -5.97 -0.31 6.12e-9 Cerebrospinal fluid t-tau:AB1-42 ratio; CRC cis rs644799 1.000 rs644799 chr11:95564259 A/G cg25478527 chr11:95522999 CEP57;FAM76B 0.53 7.97 0.4 2.64e-14 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs8031584 0.678 rs798127 chr15:31117403 T/C cg08109568 chr15:31115862 NA 0.64 10.0 0.48 9.88e-21 Huntington's disease progression; CRC cis rs17401966 0.522 rs4845930 chr1:10319049 G/A cg19773385 chr1:10388646 KIF1B -0.49 -7.88 -0.4 4.73e-14 Hepatocellular carcinoma; CRC cis rs4319547 0.695 rs6488958 chr12:122880704 A/G cg05707623 chr12:122985044 ZCCHC8 -0.69 -8.66 -0.43 2.18e-16 Body mass index; CRC trans rs1005277 0.541 rs1740741 chr10:38515334 C/T cg11292332 chr7:45801988 SEPT13 -0.39 -7.05 -0.36 1.05e-11 Extrinsic epigenetic age acceleration; CRC cis rs798554 0.797 rs35957220 chr7:2812632 C/G cg04166393 chr7:2884313 GNA12 0.51 6.57 0.34 1.91e-10 Height; CRC cis rs67311347 1.000 rs56291770 chr3:40515370 T/C cg09455208 chr3:40491958 NA 0.51 9.92 0.48 1.78e-20 Renal cell carcinoma; CRC cis rs4700695 0.841 rs152933 chr5:65359530 A/G cg21114390 chr5:65439923 SFRS12 -0.57 -6.84 -0.35 3.92e-11 Facial morphology (factor 19); CRC trans rs12188164 0.686 rs56279338 chr5:416118 G/A cg15371732 chr17:78194151 SLC26A11;SGSH 0.43 6.11 0.32 2.74e-9 Cystic fibrosis severity; CRC cis rs26868 0.740 rs26869 chr16:2248786 T/C cg07587117 chr16:2239488 CASKIN1 0.43 7.46 0.38 7.78e-13 Height; CRC cis rs7552404 0.727 rs7521344 chr1:76318325 C/T cg05598546 chr1:76251766 SNORD45C;RABGGTB -0.5 -5.73 -0.3 2.21e-8 Blood metabolite levels;Acylcarnitine levels; CRC cis rs6545883 0.525 rs2049747 chr2:61364154 G/A cg10580144 chr2:61372316 C2orf74 -0.28 -5.7 -0.3 2.63e-8 Tuberculosis; CRC trans rs7647973 0.667 rs6446286 chr3:49681704 A/G cg21659725 chr3:3221576 CRBN -0.67 -7.34 -0.38 1.72e-12 Menarche (age at onset); CRC cis rs4481887 0.927 rs6587445 chr1:248440915 A/G cg00666640 chr1:248458726 OR2T12 0.53 9.56 0.47 2.89e-19 Common traits (Other); CRC cis rs7707921 0.767 rs6894520 chr5:81594748 C/T cg07807695 chr5:81608485 ATP6AP1L 0.44 6.97 0.36 1.78e-11 Breast cancer; CRC cis rs9467160 0.765 rs793712 chr6:24446882 T/C cg20631270 chr6:24437470 GPLD1 -0.44 -6.05 -0.32 4.04e-9 Liver enzyme levels; CRC cis rs769267 0.825 rs1469713 chr19:19528806 A/G cg01262667 chr19:19385393 TM6SF2 0.37 6.23 0.33 1.39e-9 Tonsillectomy; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg06155979 chr2:232575824 PTMA 0.47 6.7 0.35 8.93e-11 Response to antipsychotic treatment; CRC cis rs7605827 0.930 rs1035246 chr2:15512891 G/A cg19274914 chr2:15703543 NA 0.39 6.03 0.32 4.36e-9 Educational attainment (years of education); CRC cis rs10991814 1.000 rs73650963 chr9:93943033 T/C cg14446406 chr9:93919335 NA 0.59 7.26 0.37 2.8e-12 Neutrophil percentage of granulocytes; CRC cis rs2346177 0.542 rs13020043 chr2:46698431 A/T cg26688816 chr2:46740690 ATP6V1E2 -0.62 -9.36 -0.46 1.27e-18 HDL cholesterol; CRC cis rs4654899 0.932 rs10916943 chr1:21472429 T/C cg02927042 chr1:21476669 EIF4G3 0.45 7.24 0.37 3.12e-12 Superior frontal gyrus grey matter volume; CRC cis rs10484885 0.775 rs55926724 chr6:90417450 A/C cg13799429 chr6:90582589 CASP8AP2 -0.77 -10.39 -0.5 4.81e-22 QRS interval (sulfonylurea treatment interaction); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg22696252 chr3:97540975 NA 0.4 6.58 0.34 1.82e-10 Liver disease severity in Alagille syndrome; CRC cis rs7927592 0.913 rs67947146 chr11:68314980 C/T cg16797656 chr11:68205561 LRP5 0.36 5.71 0.3 2.47e-8 Total body bone mineral density; CRC cis rs738322 0.967 rs4380 chr22:38569529 T/C cg17652424 chr22:38574118 PLA2G6 -0.22 -6.74 -0.35 7.11e-11 Cutaneous nevi; CRC cis rs4713118 0.513 rs149941 chr6:28001033 T/C cg06470822 chr6:28175283 NA 0.81 12.29 0.56 7.97e-29 Parkinson's disease; CRC cis rs10504073 0.647 rs10808745 chr8:49989037 G/A cg00325661 chr8:49890786 NA 0.52 9.23 0.45 3.37e-18 Blood metabolite ratios; CRC cis rs875971 0.638 rs10249404 chr7:66046724 G/A cg00343986 chr7:65444356 GUSB -0.5 -7.51 -0.38 5.55e-13 Aortic root size; CRC cis rs7647973 0.925 rs6446257 chr3:49253492 A/G cg07690219 chr3:49449608 TCTA;RHOA 0.5 5.83 0.31 1.33e-8 Menarche (age at onset); CRC cis rs11226613 0.547 rs7934144 chr11:104979884 C/T cg04181079 chr11:104896587 CASP1 -0.42 -5.68 -0.3 2.96e-8 Bronchopulmonary dysplasia; CRC cis rs2032447 0.610 rs189911 chr6:25965942 A/G cg04800585 chr6:26043546 HIST1H2BB 0.51 7.47 0.38 7.34e-13 Intelligence (multi-trait analysis); CRC cis rs561341 0.882 rs28649357 chr17:30367190 A/G cg00745463 chr17:30367425 LRRC37B -0.68 -8.05 -0.41 1.53e-14 Hip circumference adjusted for BMI; CRC cis rs644799 1.000 rs693364 chr11:95621926 A/G cg03916912 chr11:95522834 CEP57;FAM76B 0.95 17.77 0.7 5.13e-50 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs311392 0.966 rs404354 chr8:55087196 A/G cg20636351 chr8:55087400 NA -0.33 -5.9 -0.31 9.15e-9 Pelvic organ prolapse (moderate/severe); CRC cis rs6754311 0.731 rs892715 chr2:136576577 T/C cg15123519 chr2:136567270 LCT 0.33 6.39 0.33 5.65e-10 Mosquito bite size; CRC cis rs3087591 0.960 rs2905872 chr17:29525027 C/A cg24425628 chr17:29625626 OMG;NF1 0.82 15.8 0.66 3.09e-42 Hip circumference; CRC trans rs629535 0.748 rs58675625 chr8:70034924 T/C cg21567404 chr3:27674614 NA 0.95 16.08 0.66 2.35e-43 Dupuytren's disease; CRC trans rs7618501 0.602 rs2526754 chr3:50125996 G/A cg21665057 chr3:196295764 WDR53;FBXO45 -0.58 -9.35 -0.46 1.43e-18 Intelligence (multi-trait analysis); CRC cis rs3785574 0.962 rs2584633 chr17:61879501 T/C cg06873352 chr17:61820015 STRADA 0.5 8.13 0.41 8.85e-15 Height; CRC cis rs11122272 0.735 rs2739513 chr1:231515201 C/T cg06096015 chr1:231504339 EGLN1 0.4 6.04 0.32 4.23e-9 Hemoglobin concentration; CRC cis rs6662572 0.737 rs6700974 chr1:46371735 C/A cg08644498 chr1:46502608 NA -0.44 -6.85 -0.35 3.69e-11 Blood protein levels; CRC cis rs1003719 0.715 rs13046581 chr21:38551985 G/T cg10648535 chr21:38446584 PIGP;TTC3 -0.48 -6.72 -0.35 7.91e-11 Eye color traits; CRC cis rs12745968 0.623 rs10874733 chr1:93123733 A/G cg17283838 chr1:93427260 FAM69A -0.46 -6.28 -0.33 1.08e-9 Bipolar disorder and schizophrenia; CRC cis rs9916302 0.904 rs602282 chr17:37433021 C/T cg07936489 chr17:37558343 FBXL20 -0.78 -11.69 -0.54 1.18e-26 Glomerular filtration rate (creatinine); CRC cis rs79349575 0.783 rs9747646 chr17:47016882 C/T cg22482690 chr17:47019901 SNF8 0.48 8.01 0.4 2.01e-14 Type 2 diabetes; CRC cis rs514406 0.644 rs7529978 chr1:53204705 G/A cg25767906 chr1:53392781 SCP2 0.37 5.86 0.31 1.12e-8 Monocyte count; CRC cis rs9487051 1.000 rs7748918 chr6:109613564 A/G cg21918786 chr6:109611834 NA -0.38 -6.38 -0.33 6.02e-10 Reticulocyte fraction of red cells; CRC cis rs26868 0.766 rs26867 chr16:2249410 T/C cg02248941 chr16:2239361 CASKIN1 0.63 11.66 0.54 1.59e-26 Height; CRC cis rs672059 1.000 rs566625 chr1:183161441 A/G ch.1.3577855R chr1:183094577 LAMC1 0.57 8.16 0.41 6.95e-15 Hypertriglyceridemia; CRC cis rs1401999 0.898 rs4148564 chr3:183725982 C/T cg05044414 chr3:183734942 ABCC5 0.46 8.02 0.4 1.82e-14 Anterior chamber depth; CRC cis rs9341808 0.718 rs9448898 chr6:80845341 T/A cg08355045 chr6:80787529 NA 0.42 6.86 0.35 3.38e-11 Sitting height ratio; CRC cis rs4731207 0.596 rs10228686 chr7:124663086 G/A cg23710748 chr7:124431027 NA -0.39 -6.11 -0.32 2.87e-9 Cutaneous malignant melanoma; CRC cis rs727505 1.000 rs720614 chr7:124452790 T/C cg23710748 chr7:124431027 NA -0.82 -14.49 -0.62 3.67e-37 Lewy body disease; CRC cis rs561341 0.714 rs111760509 chr17:30304320 A/G cg19193384 chr17:30244184 NA -0.65 -7.54 -0.38 4.67e-13 Hip circumference adjusted for BMI; CRC cis rs11628318 0.614 rs10132160 chr14:103058023 A/G cg23071808 chr14:103021642 NA -0.64 -7.28 -0.37 2.45e-12 Platelet count; CRC trans rs67073037 0.955 rs6734079 chr2:29160421 T/A cg13899017 chr1:159158444 CADM3 -0.37 -6.14 -0.32 2.4e-9 Breast cancer;Breast cancer (estrogen-receptor negative); CRC cis rs9322193 0.923 rs10782315 chr6:150064229 T/C cg13206674 chr6:150067644 NUP43 0.66 10.02 0.48 8.65e-21 Lung cancer; CRC trans rs9914544 0.545 rs12452289 chr17:18781809 T/G cg21372672 chr17:16614065 CCDC144A -0.38 -6.03 -0.32 4.38e-9 Educational attainment (years of education); CRC cis rs6840360 1.000 rs4696285 chr4:152605449 A/G cg09659197 chr4:152720779 NA 0.5 10.68 0.51 4.69e-23 Intelligence (multi-trait analysis); CRC cis rs12190007 0.508 rs7452203 chr6:169741858 C/T cg16388071 chr6:169726476 NA -0.42 -6.61 -0.34 1.55e-10 Obesity-related traits; CRC cis rs79387448 0.745 rs7593444 chr2:103158561 G/A cg09003973 chr2:102972529 NA 0.73 8.01 0.4 1.97e-14 Gut microbiota (bacterial taxa); CRC cis rs3087591 0.708 rs67065748 chr17:29605631 T/A cg24425628 chr17:29625626 OMG;NF1 0.88 17.02 0.68 4.81e-47 Hip circumference; CRC cis rs2252521 0.553 rs2648659 chr7:29040952 A/T cg11728747 chr7:29037910 CPVL -0.47 -6.7 -0.35 8.96e-11 Cognitive performance; CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg22815056 chr20:4573300 NA 0.37 6.03 0.32 4.37e-9 Obesity-related traits; CRC cis rs4665809 1.000 rs6750681 chr2:26329677 C/T cg27170947 chr2:26402098 FAM59B -0.46 -6.11 -0.32 2.85e-9 Gut microbiome composition (summer); CRC cis rs4862750 0.794 rs7672272 chr4:187896774 T/G cg22105103 chr4:187893119 NA 0.63 11.52 0.54 4.85e-26 Lobe attachment (rater-scored or self-reported); CRC cis rs6424115 0.545 rs11576333 chr1:24065770 C/T cg08896387 chr1:24191740 FUCA1 0.46 5.77 0.3 1.81e-8 Immature fraction of reticulocytes; CRC cis rs274567 0.602 rs272853 chr5:131688561 A/G cg24060327 chr5:131705240 SLC22A5 -0.5 -7.69 -0.39 1.77e-13 Blood metabolite levels; CRC cis rs501916 0.605 rs2118917 chr15:48078992 C/T cg16110827 chr15:48056943 SEMA6D -0.47 -7.18 -0.37 4.81e-12 Inflammatory bowel disease;Ulcerative colitis; CRC cis rs394563 0.591 rs11964335 chr6:149658101 A/T cg11245181 chr6:149772854 ZC3H12D 0.52 9.12 0.45 7.79e-18 Dupuytren's disease; CRC cis rs17270561 0.636 rs6456698 chr6:25741664 A/C cg17691542 chr6:26056736 HIST1H1C 0.72 9.24 0.45 3.07e-18 Iron status biomarkers; CRC cis rs10504229 1.000 rs111915672 chr8:58191665 T/C cg01721255 chr8:58191610 C8orf71 0.5 6.17 0.32 2.06e-9 Developmental language disorder (linguistic errors); CRC cis rs6952808 0.531 rs4721441 chr7:2184060 A/G cg04267008 chr7:1944627 MAD1L1 -0.52 -7.01 -0.36 1.35e-11 Bipolar disorder and schizophrenia; CRC cis rs1008375 0.966 rs6449313 chr4:17588320 A/G cg16339924 chr4:17578868 LAP3 0.59 7.87 0.4 5.04e-14 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs4561483 0.583 rs62038798 chr16:12001569 C/T cg08843971 chr16:11963173 GSPT1 0.5 7.45 0.38 8.14e-13 Testicular germ cell tumor; CRC cis rs2734839 0.964 rs2734838 chr11:113286501 A/G cg14159747 chr11:113255604 NA 0.47 8.21 0.41 5.12e-15 Information processing speed; CRC cis rs362272 0.545 rs2749783 chr4:3326098 A/C cg08741688 chr4:3415352 RGS12 -0.39 -5.82 -0.31 1.41e-8 Serum sulfate level; CRC cis rs2012796 0.913 rs8010181 chr14:81820125 T/C cg02996355 chr14:81879375 NA 0.49 7.3 0.37 2.15e-12 Night sleep phenotypes; CRC cis rs11758351 1.000 rs17598927 chr6:26184640 C/G cg10723962 chr6:26240782 HIST1H4F 0.4 6.03 0.32 4.38e-9 Gout;Renal underexcretion gout; CRC cis rs9733 0.519 rs1336900 chr1:150679033 C/T cg15448220 chr1:150897856 SETDB1 0.47 6.76 0.35 6.27e-11 Tonsillectomy; CRC cis rs9787249 0.915 rs58589165 chr1:40213670 A/T cg01941586 chr1:40203715 PPIE -0.45 -6.21 -0.32 1.59e-9 Blood protein levels; CRC cis rs728616 0.614 rs35395602 chr10:81906770 A/G cg05935833 chr10:81318306 SFTPA2 -0.57 -6.61 -0.34 1.59e-10 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs7552404 0.924 rs1611823 chr1:76221706 T/G cg03433033 chr1:76189801 ACADM 0.74 11.17 0.52 8.95e-25 Blood metabolite levels;Acylcarnitine levels; CRC cis rs654950 0.806 rs941971 chr1:42040893 T/C cg06885757 chr1:42089581 HIVEP3 -0.53 -8.99 -0.44 2e-17 Airway imaging phenotypes; CRC cis rs427394 0.659 rs274674 chr5:6755460 C/T cg15145174 chr5:6755386 POLS -0.43 -6.21 -0.32 1.62e-9 Menopause (age at onset); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg09831311 chr16:85833828 COX4NB;COX4I1 0.42 6.11 0.32 2.83e-9 Intelligence (multi-trait analysis); CRC cis rs9467773 1.000 rs9467774 chr6:26505036 C/A cg09904177 chr6:26538194 HMGN4 0.85 14.75 0.63 3.95e-38 Intelligence (multi-trait analysis); CRC cis rs769267 0.930 rs2315022 chr19:19413381 A/G cg03709012 chr19:19516395 GATAD2A 0.7 10.72 0.51 3.35e-23 Tonsillectomy; CRC cis rs9549367 0.789 rs9549705 chr13:113888425 T/C cg00898013 chr13:113819073 PROZ -0.47 -6.89 -0.36 2.78e-11 Platelet distribution width; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg22127215 chr17:4613552 ARRB2 0.43 6.04 0.32 4.11e-9 Response to antipsychotic treatment; CRC cis rs1552244 0.935 rs7652190 chr3:10105150 G/A cg02579736 chr3:10068473 FANCD2;CIDECP 1.04 13.74 0.6 3e-34 Alzheimer's disease; CRC cis rs9287719 0.649 rs6721857 chr2:10721210 C/T cg00105475 chr2:10696890 NA -0.42 -6.73 -0.35 7.63e-11 Prostate cancer; CRC cis rs3018066 0.666 rs7662836 chr4:106997265 A/C cg01869342 chr4:106983673 TBCK 0.48 6.23 0.33 1.39e-9 Cancer; CRC cis rs10946940 1.000 rs10946940 chr6:27560587 A/G cg08798685 chr6:27730294 NA 0.4 6.13 0.32 2.56e-9 Systemic lupus erythematosus; CRC cis rs7208859 0.673 rs216418 chr17:28936537 G/A cg19761014 chr17:28927070 LRRC37B2 0.56 6.72 0.35 8.07e-11 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs6952808 0.689 rs58227534 chr7:2046328 A/G cg04267008 chr7:1944627 MAD1L1 -0.77 -11.06 -0.52 2.27e-24 Bipolar disorder and schizophrenia; CRC cis rs9814567 1.000 rs1357762 chr3:134264859 A/C cg06109529 chr3:134205091 CEP63;ANAPC13 -0.8 -11.99 -0.55 9.75e-28 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs6502050 0.835 rs67106357 chr17:80116826 T/G cg11859384 chr17:80120422 CCDC57 -0.37 -5.98 -0.31 5.86e-9 Life satisfaction; CRC cis rs7512552 0.780 rs1260411 chr1:150382088 G/A cg15654264 chr1:150340011 RPRD2 0.6 8.58 0.43 3.87e-16 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); CRC cis rs12477438 0.520 rs4851187 chr2:99745860 G/T cg14399236 chr2:99771627 LIPT1;TSGA10 -0.82 -14.62 -0.63 1.16e-37 Chronic sinus infection; CRC trans rs7618501 0.932 rs4855850 chr3:49761571 G/A cg21659725 chr3:3221576 CRBN -0.91 -17.84 -0.7 2.75e-50 Intelligence (multi-trait analysis); CRC cis rs7647973 0.588 rs62262675 chr3:49673662 A/G cg03060546 chr3:49711283 APEH -0.6 -6.67 -0.35 1.06e-10 Menarche (age at onset); CRC cis rs4481887 0.504 rs12025218 chr1:248356440 A/G cg00666640 chr1:248458726 OR2T12 0.44 7.11 0.37 7.14e-12 Common traits (Other); CRC cis rs728616 0.867 rs61860421 chr10:81743399 C/T cg11900509 chr10:81946545 ANXA11 -0.68 -6.82 -0.35 4.39e-11 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs7552404 0.656 rs11161792 chr1:76336746 C/T cg03433033 chr1:76189801 ACADM 0.69 8.75 0.43 1.09e-16 Blood metabolite levels;Acylcarnitine levels; CRC cis rs28386778 0.830 rs2665841 chr17:61861219 A/T cg07362569 chr17:61921086 SMARCD2 0.37 5.68 0.3 2.98e-8 Prudent dietary pattern; CRC cis rs929596 0.556 rs10168416 chr2:234597087 C/G cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.51 -7.57 -0.38 3.88e-13 Total bilirubin levels in HIV-1 infection; CRC cis rs250677 0.687 rs250672 chr5:148446110 A/G cg23229984 chr5:148520753 ABLIM3 0.5 6.95 0.36 1.96e-11 Breast cancer; CRC cis rs9297145 0.724 rs6954584 chr7:98766930 G/A cg05967295 chr7:98741636 SMURF1 1.13 17.87 0.7 2.24e-50 Crohn's disease;Inflammatory bowel disease;Ulcerative colitis; CRC cis rs9457247 0.765 rs10455982 chr6:167448728 C/T cg23791538 chr6:167370224 RNASET2 -0.38 -5.72 -0.3 2.41e-8 Crohn's disease; CRC cis rs9381040 0.655 rs2268187 chr6:41042993 G/A cg03644281 chr6:41068752 NFYA;LOC221442 -0.46 -6.53 -0.34 2.46e-10 Alzheimer's disease (late onset); CRC cis rs9303542 0.625 rs17703636 chr17:46566890 C/T cg04904318 chr17:46607828 HOXB1 0.5 5.92 0.31 8.21e-9 Ovarian cancer;Epithelial ovarian cancer; CRC cis rs11098499 0.754 rs1980025 chr4:120252806 A/G cg09307838 chr4:120376055 NA -0.62 -9.75 -0.47 6.62e-20 Corneal astigmatism; CRC cis rs2013441 0.965 rs8068720 chr17:20214171 G/T cg13482628 chr17:19912719 NA -0.4 -6.25 -0.33 1.28e-9 Obesity-related traits; CRC cis rs2952156 0.684 rs11658786 chr17:37815899 G/A cg07936489 chr17:37558343 FBXL20 -0.52 -7.61 -0.39 2.92e-13 Asthma; CRC cis rs68170813 0.641 rs6979368 chr7:107089009 C/G cg02696742 chr7:106810147 HBP1 -0.57 -5.91 -0.31 8.42e-9 Coronary artery disease; CRC cis rs559928 0.947 rs56339474 chr11:64142478 C/T cg19465662 chr11:63993652 NUDT22;TRPT1 0.6 5.63 0.3 3.93e-8 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; CRC cis rs28386778 0.897 rs2584635 chr17:61865934 A/G cg23090583 chr17:61904693 PSMC5;FTSJ3 1.05 20.28 0.75 7.02e-60 Prudent dietary pattern; CRC cis rs9303401 0.580 rs12946396 chr17:57164195 T/A cg10487724 chr17:56770010 TEX14;RAD51C 0.75 8.83 0.44 6.56e-17 Cognitive test performance; CRC cis rs995000 0.899 rs1748201 chr1:63045506 A/C cg19896129 chr1:63156450 NA -0.43 -6.7 -0.35 8.97e-11 Triglyceride levels; CRC cis rs3768617 0.510 rs729819 chr1:183109034 G/A ch.1.3577855R chr1:183094577 LAMC1 0.78 11.79 0.54 5.53e-27 Fuchs's corneal dystrophy; CRC cis rs1448094 0.511 rs17279464 chr12:86164473 C/T cg02569458 chr12:86230093 RASSF9 0.46 7.66 0.39 2.13e-13 Major depressive disorder; CRC trans rs1455244 0.700 rs7229302 chr18:11508904 G/T cg19092489 chr4:185375724 IRF2 -0.39 -5.97 -0.31 6.14e-9 Schizophrenia; CRC cis rs12529935 0.737 rs11967697 chr6:90966364 G/A cg06866423 chr6:90926672 BACH2 0.59 5.92 0.31 7.92e-9 Systemic lupus erythematosus; CRC trans rs2303319 0.504 rs55650699 chr2:162388931 T/C cg18122310 chr12:50236657 BCDIN3D -0.72 -6.04 -0.32 4.15e-9 Cognitive function; CRC cis rs2067615 0.524 rs4964186 chr12:107080235 C/T cg13491945 chr12:107078410 RFX4 0.36 6.21 0.32 1.63e-9 Heart rate; CRC cis rs8114671 0.562 rs6088646 chr20:33505937 T/C cg07148914 chr20:33460835 GGT7 0.39 6.33 0.33 8.21e-10 Height; CRC cis rs1005277 0.579 rs2474575 chr10:38387901 C/T cg25427524 chr10:38739819 LOC399744 -0.77 -13.64 -0.6 6.85e-34 Extrinsic epigenetic age acceleration; CRC cis rs57994353 0.897 rs3812595 chr9:139369062 C/T cg13611204 chr9:139324423 INPP5E -0.41 -5.74 -0.3 2.13e-8 Eosinophil counts;Cutaneous squamous cell carcinoma; CRC cis rs9814567 1.000 rs7645295 chr3:134307734 T/G cg06109529 chr3:134205091 CEP63;ANAPC13 -0.8 -11.66 -0.54 1.52e-26 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs2708977 0.698 rs772161 chr2:97043803 C/A cg23100626 chr2:96804247 ASTL 0.23 5.86 0.31 1.1e-8 Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes; CRC cis rs7894051 1.000 rs11101723 chr10:135192139 C/A cg24905316 chr10:135186343 ECHS1 0.78 6.87 0.35 3.18e-11 Lifespan; CRC cis rs6424115 1.000 rs6424115 chr1:24153231 A/G cg15997130 chr1:24165203 NA -0.76 -11.51 -0.54 5.64e-26 Immature fraction of reticulocytes; CRC cis rs2276314 0.857 rs8097597 chr18:33619448 A/G cg05985134 chr18:33552581 C18orf21 0.48 6.79 0.35 5.24e-11 Endometriosis;Drug-induced torsades de pointes; CRC cis rs853679 0.607 rs34661125 chr6:28281894 G/A cg15845792 chr6:28175446 NA 0.85 5.82 0.31 1.36e-8 Depression; CRC trans rs17685 0.712 rs6464994 chr7:75784668 C/T cg19862616 chr7:65841803 NCRNA00174 0.95 17.19 0.69 9.99e-48 Coffee consumption;Coffee consumption (cups per day); CRC cis rs11077998 0.967 rs4789796 chr17:80521135 T/C cg10255544 chr17:80519551 FOXK2 0.36 5.64 0.3 3.72e-8 Reticulocyte fraction of red cells; CRC trans rs10243593 0.673 rs773393 chr7:40044282 A/G cg13911576 chr9:84174038 NA -0.34 -6.0 -0.31 5.21e-9 Lymphocyte counts; CRC cis rs10888329 0.665 rs9662722 chr1:248385891 T/G cg00666640 chr1:248458726 OR2T12 0.46 7.2 0.37 4.14e-12 Autism spectrum disorder; CRC cis rs9902453 0.868 rs9902340 chr17:28476458 G/T cg26525008 chr17:28256777 EFCAB5;SSH2 -0.69 -11.22 -0.53 5.75e-25 Coffee consumption (cups per day); CRC cis rs2739330 0.796 rs2154594 chr22:24254055 A/G cg10150615 chr22:24372951 LOC391322 0.61 9.47 0.46 5.55e-19 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs7833986 1.000 rs34037954 chr8:57096841 A/G cg23139584 chr8:56987506 RPS20;SNORD54 0.62 7.56 0.38 3.94e-13 Height; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg23181591 chr8:123793873 ZHX2 0.49 6.32 0.33 8.51e-10 Thyroid stimulating hormone; CRC cis rs9660180 0.837 rs915292 chr1:1792157 A/C cg03396347 chr1:1875803 NA -0.63 -9.81 -0.48 4.13e-20 Body mass index; CRC cis rs7246657 0.943 rs7252346 chr19:37914682 G/A cg23950597 chr19:37808831 NA -0.49 -6.09 -0.32 3.18e-9 Coronary artery calcification; CRC cis rs2180341 1.000 rs9388561 chr6:127634921 C/T cg27446573 chr6:127587934 RNF146 0.98 14.44 0.62 6.21e-37 Breast cancer; CRC cis rs6540559 1.000 rs6696825 chr1:209982372 A/G cg21951975 chr1:209979733 IRF6 0.4 6.32 0.33 8.65e-10 Cleft lip with or without cleft palate; CRC cis rs7107174 0.901 rs10899497 chr11:78124534 T/C cg02023728 chr11:77925099 USP35 0.42 6.31 0.33 9.16e-10 Testicular germ cell tumor; CRC cis rs11958404 1.000 rs72816532 chr5:157413130 C/T cg05962755 chr5:157440814 NA 0.78 10.75 0.51 2.66e-23 IgG glycosylation; CRC cis rs7264396 0.733 rs2425105 chr20:34312834 C/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.65 -11.03 -0.52 2.68e-24 Total cholesterol levels; CRC trans rs2303319 0.504 rs62188988 chr2:162531068 T/C cg22922770 chr7:98923339 ARPC1A -0.68 -6.14 -0.32 2.35e-9 Cognitive function; CRC cis rs7737355 0.947 rs31258 chr5:130824536 G/A cg06307176 chr5:131281290 NA 0.41 6.02 0.31 4.78e-9 Life satisfaction; CRC cis rs6831352 0.819 rs1230155 chr4:99989259 C/T cg13256891 chr4:100009986 ADH5 0.52 7.3 0.37 2.14e-12 Alcohol dependence; CRC cis rs76419734 0.510 rs2544417 chr4:106745405 A/G cg24545054 chr4:106630052 GSTCD;INTS12 -0.54 -6.18 -0.32 1.85e-9 Post bronchodilator FEV1; CRC trans rs116095464 0.558 rs7725227 chr5:233517 G/A cg00938859 chr5:1591904 SDHAP3 0.72 7.77 0.39 1.04e-13 Breast cancer; CRC cis rs1552244 0.572 rs58862481 chr3:10164308 G/A cg08888203 chr3:10149979 C3orf24 0.74 9.0 0.44 1.82e-17 Alzheimer's disease; CRC cis rs6088813 1.000 rs6087704 chr20:34001058 C/T cg14752227 chr20:34000481 UQCC -0.37 -5.64 -0.3 3.7e-8 Height; CRC cis rs7833790 0.724 rs6473311 chr8:82726682 G/A cg17211192 chr8:82754475 SNX16 -0.48 -6.84 -0.35 3.75e-11 Diastolic blood pressure; CRC cis rs9462846 0.725 rs6927188 chr6:42912589 C/T cg10862848 chr6:42927986 GNMT 0.34 6.48 0.34 3.34e-10 Blood protein levels; CRC cis rs10504229 0.636 rs77290284 chr8:58055269 G/T cg11062466 chr8:58055876 NA 0.55 6.76 0.35 6.4e-11 Developmental language disorder (linguistic errors); CRC cis rs9814567 1.000 rs62269547 chr3:134214042 T/C cg06541857 chr3:134203789 ANAPC13;CEP63 -0.41 -6.22 -0.32 1.48e-9 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs10450586 0.677 rs7110359 chr11:27300429 A/T cg10370305 chr11:27303972 NA 0.39 6.32 0.33 8.69e-10 Total body bone mineral density; CRC cis rs9560113 1.000 rs914026 chr13:112182029 G/A cg14154082 chr13:112174009 NA 0.35 5.65 0.3 3.54e-8 Menarche (age at onset); CRC cis rs533581 0.866 rs502258 chr16:88968547 G/A cg09141835 chr16:88988174 CBFA2T3 -0.28 -5.9 -0.31 8.9e-9 Social autistic-like traits; CRC cis rs3733585 0.699 rs62294331 chr4:9959889 A/G cg11266682 chr4:10021025 SLC2A9 -0.47 -9.67 -0.47 1.2e-19 Cleft plate (environmental tobacco smoke interaction); CRC trans rs2553218 0.690 rs8032415 chr15:54851945 A/G cg05253283 chr3:195717344 SDHAP1 0.44 5.97 0.31 6.3e-9 Immune response to smallpox vaccine (IL-6); CRC cis rs539096 0.500 rs2906457 chr1:44338575 A/C cg13606994 chr1:44402422 ARTN -0.34 -5.79 -0.3 1.65e-8 Intelligence (multi-trait analysis); CRC cis rs1552244 1.000 rs61052895 chr3:10147516 G/A cg10729496 chr3:10149963 C3orf24 0.53 6.93 0.36 2.25e-11 Alzheimer's disease; CRC trans rs7615952 0.932 rs3811679 chr3:125648283 A/G cg02007433 chr3:129722099 NA -0.45 -6.08 -0.32 3.24e-9 Blood pressure (smoking interaction); CRC cis rs17270561 0.779 rs12209218 chr6:25887776 C/A cg17691542 chr6:26056736 HIST1H1C 0.79 10.18 0.49 2.52e-21 Iron status biomarkers; CRC cis rs2011503 1.000 rs4808962 chr19:19579557 A/G cg11584989 chr19:19387371 SF4 0.54 6.1 0.32 2.99e-9 Bipolar disorder; CRC cis rs748404 0.697 rs505249 chr15:43559960 T/A cg02155558 chr15:43621948 ADAL;LCMT2 0.45 6.71 0.35 8.3e-11 Lung cancer; CRC cis rs28386778 0.897 rs2665795 chr17:61925272 A/G cg07362569 chr17:61921086 SMARCD2 -0.38 -5.94 -0.31 7.14e-9 Prudent dietary pattern; CRC cis rs875971 0.862 rs801209 chr7:66019390 G/T cg18252515 chr7:66147081 NA 0.43 6.21 0.32 1.61e-9 Aortic root size; CRC cis rs7843479 0.543 rs10866823 chr8:21781629 C/T cg16476235 chr8:21771668 DOK2 0.4 6.51 0.34 2.78e-10 Mean corpuscular volume; CRC cis rs910316 0.934 rs8006587 chr14:75664939 A/G cg08847533 chr14:75593920 NEK9 0.86 15.42 0.65 9.15e-41 Height; CRC cis rs2734839 0.927 rs2734837 chr11:113286829 C/T cg14159747 chr11:113255604 NA 0.43 7.4 0.38 1.13e-12 Information processing speed; CRC cis rs11212617 1.000 rs600329 chr11:108163733 A/G cg01991180 chr11:108092276 ATM;NPAT 0.42 6.02 0.32 4.58e-9 Response to metformin in type 2 diabetes (glycemic); CRC cis rs3617 0.599 rs12487379 chr3:52895785 G/A cg07507251 chr3:52567010 NT5DC2 0.41 6.02 0.32 4.53e-9 Red blood cell count;Autism spectrum disorder or schizophrenia; CRC cis rs12893668 0.572 rs11846404 chr14:104156108 C/G cg01849466 chr14:104193079 ZFYVE21 -0.4 -5.95 -0.31 6.98e-9 Reticulocyte count; CRC cis rs60154123 0.505 rs7540237 chr1:210053325 C/T cg22029157 chr1:209979665 IRF6 0.62 6.79 0.35 5.36e-11 Coronary artery disease; CRC cis rs2795502 0.564 rs11239842 chr10:43444882 A/G cg08461752 chr10:43522343 NA -0.64 -5.93 -0.31 7.66e-9 Blood protein levels; CRC cis rs12586317 0.508 rs10134914 chr14:35425012 T/G cg05294307 chr14:35346193 BAZ1A -0.68 -8.7 -0.43 1.67e-16 Psoriasis; CRC cis rs7769051 0.803 rs12193474 chr6:133186168 T/C cg22852734 chr6:133119734 C6orf192 0.99 11.19 0.53 7.36e-25 Type 2 diabetes nephropathy; CRC cis rs4862750 0.872 rs7672831 chr4:187898882 C/T cg03647317 chr4:187891568 NA -0.54 -10.17 -0.49 2.69e-21 Lobe attachment (rater-scored or self-reported); CRC cis rs7618915 0.547 rs34610878 chr3:52759169 G/C cg08222913 chr3:52553049 STAB1 -0.34 -6.15 -0.32 2.29e-9 Bipolar disorder; CRC cis rs7589728 0.858 rs1914734 chr2:88529509 T/C cg14558114 chr2:88469736 THNSL2 0.52 5.9 0.31 8.92e-9 Plasma clusterin levels; CRC cis rs243505 0.660 rs1880358 chr7:148572504 C/T cg09806900 chr7:148480153 CUL1 0.45 5.94 0.31 7.17e-9 Inflammatory bowel disease;Crohn's disease; CRC cis rs9322193 0.923 rs11155674 chr6:150032247 T/C cg05861140 chr6:150128134 PCMT1 -0.36 -5.85 -0.31 1.18e-8 Lung cancer; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg07017275 chr14:55738748 FBXO34 -0.42 -6.63 -0.34 1.36e-10 Myopia (pathological); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg08450913 chr19:7694688 XAB2;LOC100131801 0.43 6.04 0.32 4.08e-9 Intelligence (multi-trait analysis); CRC cis rs823143 0.570 rs823084 chr1:205798313 G/T cg17178900 chr1:205818956 PM20D1 0.55 8.33 0.42 2.26e-15 Monocyte percentage of white cells; CRC cis rs9303280 0.836 rs11557467 chr17:38028634 G/T cg00129232 chr17:37814104 STARD3 -0.46 -7.32 -0.37 1.88e-12 Self-reported allergy; CRC cis rs2346177 0.576 rs1530621 chr2:46688688 T/C cg26688816 chr2:46740690 ATP6V1E2 -0.62 -9.36 -0.46 1.33e-18 HDL cholesterol; CRC cis rs2279817 0.818 rs883379 chr1:17983789 G/A cg21791023 chr1:18019539 ARHGEF10L -0.47 -5.69 -0.3 2.81e-8 Neuroticism; CRC cis rs1448094 0.511 rs7139088 chr12:86147878 T/C cg25456477 chr12:86230367 RASSF9 -0.36 -6.07 -0.32 3.43e-9 Major depressive disorder; CRC cis rs55794721 0.509 rs4649085 chr1:25778832 G/A cg27572855 chr1:25598939 RHD 0.37 6.58 0.34 1.86e-10 Plateletcrit;Mean corpuscular volume; CRC cis rs3126085 0.935 rs1552995 chr1:152171427 A/G cg09127314 chr1:152161683 NA 0.52 6.58 0.34 1.82e-10 Atopic dermatitis; CRC cis rs6860806 0.631 rs7736284 chr5:131588151 T/C cg18301423 chr5:131593218 PDLIM4 0.38 7.1 0.36 7.67e-12 Breast cancer; CRC cis rs10504229 0.906 rs114627636 chr8:58173732 C/T cg21724239 chr8:58056113 NA 0.75 8.8 0.44 8.08e-17 Developmental language disorder (linguistic errors); CRC cis rs9611565 0.921 rs2235846 chr22:41741042 G/C cg06634786 chr22:41940651 POLR3H -0.41 -5.75 -0.3 1.99e-8 Vitiligo; CRC cis rs929354 1.000 rs1182413 chr7:157058557 G/A cg17757837 chr7:157058334 UBE3C -0.88 -17.1 -0.69 2.3e-47 Body mass index; CRC cis rs10464366 0.544 rs4355688 chr7:39158402 C/T cg18850127 chr7:39170497 POU6F2 0.58 7.65 0.39 2.27e-13 IgG glycosylation; CRC cis rs116095464 1.000 rs55671190 chr5:287422 G/A cg22857025 chr5:266934 NA -1.03 -7.99 -0.4 2.28e-14 Breast cancer; CRC cis rs2742417 0.609 rs2673066 chr3:45771200 C/T cg04837898 chr3:45731254 SACM1L -0.48 -7.69 -0.39 1.74e-13 Response to anti-depressant treatment in major depressive disorder; CRC cis rs4141404 0.787 rs4820042 chr22:31589056 T/C cg22777020 chr22:31556080 RNF185 -0.53 -6.2 -0.32 1.72e-9 Paclitaxel-induced neuropathy; CRC cis rs9322193 0.887 rs9505824 chr6:149954799 A/G cg00933542 chr6:150070202 PCMT1 0.29 6.08 0.32 3.37e-9 Lung cancer; CRC cis rs9768139 0.935 rs116290351 chr7:158119712 T/A cg24154853 chr7:158122151 PTPRN2 -0.58 -9.6 -0.47 2.14e-19 Calcium levels; CRC cis rs4625783 0.583 rs11077974 chr17:80095193 A/G cg25804541 chr17:80189381 SLC16A3 -0.31 -5.97 -0.31 6.08e-9 Blood metabolite levels; CRC cis rs9322193 0.847 rs12191643 chr6:149950048 C/T cg13206674 chr6:150067644 NUP43 0.68 10.17 0.49 2.64e-21 Lung cancer; CRC cis rs10504229 0.683 rs903706 chr8:58128134 T/G cg02725872 chr8:58115012 NA -0.64 -11.55 -0.54 3.85e-26 Developmental language disorder (linguistic errors); CRC cis rs6088580 0.660 rs6059893 chr20:33105897 T/G cg08999081 chr20:33150536 PIGU 0.63 11.63 0.54 2.1e-26 Glomerular filtration rate (creatinine); CRC trans rs11098499 0.657 rs4463052 chr4:120313258 T/C cg25214090 chr10:38739885 LOC399744 0.62 9.74 0.47 7.35e-20 Corneal astigmatism; CRC cis rs3750965 0.959 rs4930264 chr11:68852181 C/T cg06818126 chr11:68850279 TPCN2 -0.51 -7.29 -0.37 2.38e-12 Hair color; CRC cis rs9549367 0.789 rs12584008 chr13:113881228 C/T cg00898013 chr13:113819073 PROZ -0.46 -6.76 -0.35 6.31e-11 Platelet distribution width; CRC trans rs703108 0.731 rs7898954 chr10:22323646 A/G cg20625393 chr4:95128694 SMARCAD1 -0.5 -6.2 -0.32 1.73e-9 Monocyte percentage of white cells; CRC cis rs2204008 0.775 rs8186812 chr12:38305055 C/T cg26384229 chr12:38710491 ALG10B 0.68 9.73 0.47 8.12e-20 Bladder cancer; CRC cis rs9322193 0.923 rs7769101 chr6:150169904 C/A cg07701084 chr6:150067640 NUP43 0.5 7.19 0.37 4.47e-12 Lung cancer; CRC cis rs1816752 0.905 rs7995492 chr13:25013023 A/T cg02811702 chr13:24901961 NA 0.43 5.96 0.31 6.58e-9 Obesity-related traits; CRC cis rs2455601 0.608 rs16906256 chr11:8887097 A/G cg09997546 chr11:8931473 C11orf17;ST5 -0.41 -6.08 -0.32 3.36e-9 Schizophrenia; CRC cis rs1448094 1.000 rs10083080 chr12:86348579 G/C cg02569458 chr12:86230093 RASSF9 0.39 6.65 0.34 1.25e-10 Major depressive disorder; CRC cis rs59918340 0.728 rs6987335 chr8:142235358 T/G cg03316587 chr8:142245164 NA 0.44 6.59 0.34 1.75e-10 Immature fraction of reticulocytes; CRC cis rs8060686 0.844 rs3785100 chr16:67997920 T/C cg07125278 chr16:67683757 RLTPR -0.58 -6.15 -0.32 2.26e-9 HDL cholesterol;Metabolic syndrome; CRC cis rs10504229 0.679 rs75402323 chr8:58136227 A/G cg02290350 chr8:58132656 NA -0.58 -8.16 -0.41 7.29e-15 Developmental language disorder (linguistic errors); CRC cis rs3750082 0.852 rs10260000 chr7:32898234 T/C cg05721444 chr7:32995514 FKBP9 0.5 7.66 0.39 2.04e-13 Glomerular filtration rate (creatinine); CRC cis rs7811142 0.720 rs112622797 chr7:99917416 G/A cg00814883 chr7:100076585 TSC22D4 -0.7 -8.17 -0.41 6.9e-15 Platelet count; CRC cis rs7605827 0.897 rs6431715 chr2:15717917 C/A cg19274914 chr2:15703543 NA 0.41 6.15 0.32 2.25e-9 Educational attainment (years of education); CRC cis rs651907 0.557 rs11924013 chr3:101366698 G/A cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.69 9.72 0.47 8.43e-20 Colorectal cancer; CRC cis rs7777484 0.500 rs2533885 chr7:2835655 C/T cg13628971 chr7:2884303 GNA12 0.36 5.64 0.3 3.68e-8 Height; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg08208505 chr16:68119244 NFATC3 0.48 6.7 0.35 8.98e-11 Anxiety disorder; CRC cis rs62103177 0.810 rs62103195 chr18:77629693 T/C cg12964065 chr18:77638022 KCNG2 0.68 6.81 0.35 4.68e-11 Opioid sensitivity; CRC cis rs4731207 0.596 rs10275296 chr7:124681292 T/A cg23710748 chr7:124431027 NA -0.4 -6.28 -0.33 1.06e-9 Cutaneous malignant melanoma; CRC cis rs9467711 0.606 rs2072803 chr6:26392515 G/C cg08501292 chr6:25962987 TRIM38 0.84 6.5 0.34 2.97e-10 Autism spectrum disorder or schizophrenia; CRC cis rs1799949 0.965 rs11650913 chr17:41331597 T/C cg01879757 chr17:41196368 BRCA1 -0.44 -6.69 -0.35 9.45e-11 Menopause (age at onset); CRC cis rs1728785 0.818 rs1728769 chr16:68564186 C/T cg02972257 chr16:68554789 NA -0.58 -7.08 -0.36 9.03e-12 Ulcerative colitis; CRC cis rs1881797 1.000 rs67977965 chr1:247687835 G/A cg21399703 chr1:247681439 NA 0.46 7.61 0.39 2.97e-13 Acute lymphoblastic leukemia (childhood); CRC cis rs4930103 0.935 rs11042170 chr11:2021625 C/T cg06197492 chr11:2016605 H19 0.42 6.44 0.33 4.24e-10 DNA methylation (parent-of-origin);DNA methylation (variation); CRC cis rs9534288 0.797 rs994351 chr13:46588194 A/G cg15192986 chr13:46630673 CPB2 -0.67 -9.85 -0.48 3.16e-20 Blood protein levels; CRC cis rs6963495 0.818 rs73192125 chr7:105175068 A/C cg02135003 chr7:105160482 PUS7 -0.73 -10.37 -0.5 5.48e-22 Bipolar disorder (body mass index interaction); CRC cis rs9916302 0.706 rs9909304 chr17:37500508 G/T cg00129232 chr17:37814104 STARD3 0.58 7.06 0.36 9.8e-12 Glomerular filtration rate (creatinine); CRC cis rs1046896 1.000 rs1046875 chr17:80685426 A/G cg02398342 chr17:80708632 TBCD;FN3K -0.35 -5.64 -0.3 3.75e-8 Glycated hemoglobin levels; CRC trans rs1549309 0.597 rs10454960 chr5:167240944 A/G cg08634079 chr15:65478037 CLPX 0.44 6.08 0.32 3.34e-9 Dietary macronutrient intake; CRC cis rs1707322 1.000 rs1768817 chr1:46514534 C/G cg06784218 chr1:46089804 CCDC17 -0.55 -9.74 -0.47 7.37e-20 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs6951245 1.000 rs6951245 chr7:1058193 G/A cg21664854 chr7:1097933 C7orf50;GPR146 0.77 8.66 0.43 2.09e-16 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs7677751 0.767 rs6554158 chr4:55066077 G/A cg17187183 chr4:55093834 PDGFRA 0.49 6.91 0.36 2.51e-11 Corneal astigmatism; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg01156768 chr18:77439120 CTDP1 0.43 6.8 0.35 5.09e-11 Liver disease severity in Alagille syndrome; CRC cis rs909002 0.772 rs10798876 chr1:32074514 C/G cg01639898 chr1:32083012 HCRTR1 0.3 6.1 0.32 3e-9 Intelligence (multi-trait analysis); CRC trans rs7615952 0.546 rs2979350 chr3:125362215 T/C cg07211511 chr3:129823064 LOC729375 -0.59 -6.9 -0.36 2.74e-11 Blood pressure (smoking interaction); CRC cis rs1322512 0.760 rs818451 chr6:152924673 T/G cg03415253 chr6:152958462 SYNE1 -0.41 -6.51 -0.34 2.81e-10 Tonometry; CRC cis rs889398 0.641 rs7200258 chr16:69897469 T/G cg00738113 chr16:70207722 CLEC18C -0.42 -7.37 -0.38 1.43e-12 Body mass index; CRC cis rs7618501 0.633 rs11130234 chr3:50024758 G/T cg24308560 chr3:49941425 MST1R -0.51 -8.22 -0.41 4.87e-15 Intelligence (multi-trait analysis); CRC cis rs2652834 0.950 rs2729789 chr15:63400345 G/A cg05507819 chr15:63340323 TPM1 0.46 5.75 0.3 2.05e-8 HDL cholesterol; CRC cis rs6502050 0.835 rs4789754 chr17:80091941 C/T cg02741985 chr17:80059408 CCDC57 0.44 7.21 0.37 3.95e-12 Life satisfaction; CRC cis rs7932354 0.528 rs12224096 chr11:47174361 C/T cg03339077 chr11:47165057 C11orf49 -0.46 -6.55 -0.34 2.18e-10 Bone mineral density (hip);Bone mineral density; CRC cis rs514406 0.547 rs377808 chr1:53190359 T/G cg27535305 chr1:53392650 SCP2 -0.36 -6.46 -0.34 3.73e-10 Monocyte count; CRC cis rs6951245 1.000 rs74369356 chr7:1071711 T/C cg26224354 chr7:1096374 C7orf50;GPR146 -0.88 -11.08 -0.52 1.89e-24 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs4713118 0.911 rs9461406 chr6:27719764 C/T cg15786705 chr6:28176104 NA -0.57 -7.03 -0.36 1.22e-11 Parkinson's disease; CRC cis rs7107770 0.663 rs2015290 chr11:125073825 T/C cg27629782 chr11:125073726 PKNOX2 0.5 7.22 0.37 3.72e-12 Photic sneeze reflex; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg21623771 chr12:116971139 NCRNA00173 0.35 6.26 0.33 1.19e-9 Liver disease severity in Alagille syndrome; CRC cis rs7666738 0.888 rs13110683 chr4:98983368 G/C cg05340658 chr4:99064831 C4orf37 0.51 7.22 0.37 3.6e-12 Colonoscopy-negative controls vs population controls; CRC cis rs7224685 1.000 rs7224685 chr17:4014384 G/T cg09695851 chr17:3907499 NA 0.56 8.48 0.42 7.46e-16 Type 2 diabetes; CRC cis rs780096 0.526 rs2911713 chr2:27640980 G/A cg17158414 chr2:27665306 KRTCAP3 -0.28 -6.14 -0.32 2.44e-9 Total body bone mineral density; CRC cis rs6662572 0.737 rs9429179 chr1:46514198 A/G cg08644498 chr1:46502608 NA 0.47 7.52 0.38 5.41e-13 Blood protein levels; CRC cis rs3820068 0.580 rs12746773 chr1:16001588 C/T cg24675056 chr1:15929824 NA 0.52 7.03 0.36 1.22e-11 Systolic blood pressure; CRC trans rs12478296 1.000 rs55742408 chr2:243041077 G/A cg18288967 chr1:45987694 PRDX1 0.7 7.9 0.4 4.22e-14 Obesity-related traits; CRC cis rs12586317 0.547 rs78609489 chr14:35497285 T/C cg16230307 chr14:35515116 FAM177A1 0.88 10.34 0.5 6.76e-22 Psoriasis; CRC cis rs2816062 0.775 rs2745315 chr1:18897118 G/A cg18795169 chr1:18902165 NA -0.92 -19.05 -0.72 4.62e-55 Urate levels in lean individuals; CRC cis rs26868 0.740 rs26869 chr16:2248786 T/C cg02248941 chr16:2239361 CASKIN1 0.63 11.44 0.53 1.01e-25 Height; CRC cis rs6951245 1.000 rs11763835 chr7:1094513 A/G cg24642844 chr7:1081250 C7orf50 -0.79 -9.5 -0.46 4.59e-19 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs9739070 1 rs9739070 chr12:123771032 A/G cg00376283 chr12:123451042 ABCB9 0.52 6.35 0.33 7.25e-10 Allergy; CRC cis rs875971 0.789 rs28815324 chr7:65565776 A/T cg18876405 chr7:65276391 NA -0.44 -5.97 -0.31 6.3e-9 Aortic root size; CRC cis rs2727020 0.521 rs11040408 chr11:49534880 A/T cg02254774 chr11:50257496 LOC441601 0.41 5.62 0.3 4.12e-8 Coronary artery disease; CRC cis rs28735056 0.904 rs11520415 chr18:77620620 C/T cg12845895 chr18:77676008 PQLC1 0.4 5.66 0.3 3.27e-8 Schizophrenia; CRC trans rs10504229 1.000 rs67237174 chr8:58175776 T/C cg04077850 chr5:125800366 GRAMD3 0.37 6.19 0.32 1.75e-9 Developmental language disorder (linguistic errors); CRC trans rs7267979 0.714 rs1555329 chr20:25231858 G/A cg17903999 chr18:56338584 MALT1 -0.42 -6.69 -0.35 9.4e-11 Liver enzyme levels (alkaline phosphatase); CRC cis rs875971 0.558 rs4433015 chr7:65639723 A/C cg18876405 chr7:65276391 NA -0.62 -11.12 -0.52 1.36e-24 Aortic root size; CRC cis rs7589728 1.000 rs2363731 chr2:88521793 C/T cg14558114 chr2:88469736 THNSL2 0.58 5.76 0.3 1.97e-8 Plasma clusterin levels; CRC cis rs826838 1.000 rs4575342 chr12:38663831 G/A cg26384229 chr12:38710491 ALG10B 0.72 10.23 0.49 1.61e-21 Heart rate; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg07555597 chr2:62423100 B3GNT2 -0.44 -6.23 -0.32 1.39e-9 Myopia (pathological); CRC cis rs9868809 0.656 rs73078362 chr3:48703917 G/C cg00383909 chr3:49044727 WDR6 1.34 10.64 0.51 6.25e-23 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; CRC trans rs75246769 1.000 rs80293476 chr7:145644391 C/A cg21982490 chr5:124845866 NA -0.64 -5.96 -0.31 6.46e-9 Facial morphology (factor 10, width of nasal floor); CRC cis rs9283706 0.608 rs71626484 chr5:66334502 A/T cg11590213 chr5:66331682 MAST4 0.4 5.62 0.3 4.06e-8 Coronary artery disease; CRC cis rs1163251 0.902 rs487081 chr1:120217389 G/A cg19096424 chr1:120255104 PHGDH 0.46 6.65 0.34 1.2e-10 Blood metabolite levels; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg08555112 chr17:48942811 TOB1 0.46 6.63 0.34 1.41e-10 Response to antipsychotic treatment; CRC cis rs7772486 0.641 rs960385 chr6:146371074 G/A cg23711669 chr6:146136114 FBXO30 0.58 8.38 0.42 1.56e-15 Lobe attachment (rater-scored or self-reported); CRC cis rs7772486 0.875 rs2748497 chr6:146319417 C/T cg23711669 chr6:146136114 FBXO30 0.62 10.16 0.49 2.95e-21 Lobe attachment (rater-scored or self-reported); CRC cis rs11098699 0.821 rs931705 chr4:124205194 C/T cg09941581 chr4:124220074 SPATA5 0.4 5.87 0.31 1.08e-8 Mosquito bite size; CRC cis rs2072510 0.593 rs2247304 chr12:96424665 T/C cg09636302 chr12:96389483 HAL -0.52 -6.59 -0.34 1.77e-10 Metabolite levels (small molecules and protein measures); CRC cis rs7811142 0.943 rs28578163 chr7:100044754 A/G cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.62 8.34 0.42 2.01e-15 Platelet count; CRC cis rs9814567 0.896 rs6763188 chr3:134349995 G/A cg06109529 chr3:134205091 CEP63;ANAPC13 0.68 9.79 0.48 4.84e-20 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs780096 0.526 rs1260342 chr2:27663416 G/T cg12648201 chr2:27665141 KRTCAP3 -0.32 -6.36 -0.33 6.91e-10 Total body bone mineral density; CRC cis rs8177179 0.967 rs4443173 chr3:133439378 A/G cg16262614 chr3:133464971 TF 0.45 8.42 0.42 1.2e-15 Iron status biomarkers (transferrin levels); CRC cis rs2836974 0.526 rs1888488 chr21:40686521 C/T cg06238570 chr21:40685208 BRWD1 -0.82 -12.92 -0.58 3.51e-31 Cognitive function; CRC cis rs72781680 0.821 rs72796378 chr2:24167385 G/A cg08917208 chr2:24149416 ATAD2B 0.56 6.76 0.35 6.37e-11 Lymphocyte counts; CRC cis rs7833986 0.501 rs72653917 chr8:56892844 T/A cg23139584 chr8:56987506 RPS20;SNORD54 0.78 11.25 0.53 4.49e-25 Height; CRC cis rs11148252 0.514 rs2296347 chr13:52728423 A/C cg00495681 chr13:53174319 NA -0.56 -8.09 -0.41 1.14e-14 Lewy body disease; CRC cis rs3008870 1.000 rs2182143 chr1:67378936 T/C cg08660285 chr1:67390436 MIER1;WDR78 1.05 16.33 0.67 2.62e-44 Lymphocyte percentage of white cells; CRC cis rs9733 0.569 rs11204691 chr1:150644339 A/T cg18016565 chr1:150552671 MCL1 0.46 6.74 0.35 6.91e-11 Tonsillectomy; CRC cis rs7739232 0.920 rs79905210 chr6:53523634 T/C cg15658676 chr6:53530538 KLHL31 -0.75 -5.88 -0.31 1.03e-8 Hip circumference adjusted for BMI; CRC cis rs9902453 0.765 rs2467334 chr17:28135508 A/C cg26525008 chr17:28256777 EFCAB5;SSH2 -0.73 -12.22 -0.56 1.39e-28 Coffee consumption (cups per day); CRC cis rs9926296 0.533 rs10852623 chr16:89865242 T/C cg04287289 chr16:89883240 FANCA 0.82 15.38 0.65 1.32e-40 Vitiligo; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg11588644 chr17:7761052 CYB5D1;LSMD1 0.44 6.33 0.33 8.1e-10 Intelligence (multi-trait analysis); CRC cis rs2153535 0.526 rs1796689 chr6:8536433 A/C cg07606381 chr6:8435919 SLC35B3 0.68 11.03 0.52 2.82e-24 Motion sickness; CRC cis rs4731207 0.591 rs11772336 chr7:124589796 G/A cg23710748 chr7:124431027 NA -0.38 -6.08 -0.32 3.35e-9 Cutaneous malignant melanoma; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg21086066 chr17:27920376 ANKRD13B 0.46 6.32 0.33 8.41e-10 Anxiety disorder; CRC cis rs7296418 0.961 rs4148862 chr12:123568619 A/C cg13010344 chr12:123464640 ARL6IP4 -0.36 -6.22 -0.32 1.53e-9 Platelet count; CRC cis rs4466137 0.909 rs4466136 chr5:82985576 T/G cg15083037 chr5:83017644 HAPLN1 -0.46 -6.05 -0.32 4.03e-9 Prostate cancer; CRC cis rs6547741 1.000 rs6737921 chr2:27839107 T/C cg27432699 chr2:27873401 GPN1 0.77 13.82 0.61 1.45e-34 Oral cavity cancer; CRC cis rs11209185 0.509 rs1926279 chr1:68450681 A/G cg22082780 chr1:68452167 NA 0.37 5.9 0.31 9.17e-9 Itch intensity from mosquito bite adjusted by bite size; CRC cis rs4631830 0.900 rs10763588 chr10:51539762 G/T cg16070123 chr10:51489643 NA -0.34 -5.76 -0.3 1.95e-8 Prostate-specific antigen levels; CRC cis rs9322193 0.884 rs7744105 chr6:150170444 A/G cg05861140 chr6:150128134 PCMT1 -0.42 -6.74 -0.35 7.32e-11 Lung cancer; CRC cis rs6952808 0.692 rs10950473 chr7:1999453 G/A cg21782813 chr7:2030301 MAD1L1 0.5 8.55 0.43 4.62e-16 Bipolar disorder and schizophrenia; CRC cis rs11628318 0.614 rs7155883 chr14:103123404 A/C cg23461800 chr14:103021989 NA 0.69 7.84 0.4 6.5e-14 Platelet count; CRC cis rs7208859 0.725 rs9910051 chr17:29161202 A/T cg14008862 chr17:28927542 LRRC37B2 0.5 6.01 0.31 4.94e-9 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs9322193 0.884 rs9397036 chr6:150172923 C/T cg05861140 chr6:150128134 PCMT1 -0.43 -7.01 -0.36 1.36e-11 Lung cancer; CRC cis rs17641971 0.684 rs1511367 chr8:49949412 T/C cg00325661 chr8:49890786 NA 0.36 6.28 0.33 1.05e-9 Blood metabolite levels; CRC cis rs1873147 0.569 rs58819603 chr15:63310866 T/A cg12160578 chr15:63334699 TPM1 0.63 7.53 0.38 5.02e-13 Orofacial clefts; CRC cis rs9487051 0.735 rs459956 chr6:109524760 A/G cg21918786 chr6:109611834 NA -0.33 -5.61 -0.3 4.38e-8 Reticulocyte fraction of red cells; CRC cis rs17270561 0.636 rs1575535 chr6:25809909 C/T cg17691542 chr6:26056736 HIST1H1C 0.6 8.05 0.41 1.58e-14 Iron status biomarkers; CRC cis rs67311347 0.955 rs9821036 chr3:40379007 A/G cg09455208 chr3:40491958 NA 0.43 8.56 0.43 4.53e-16 Renal cell carcinoma; CRC trans rs13434995 0.842 rs62305269 chr4:56373404 C/A cg05873268 chr16:1290058 TPSAB1 -0.43 -6.24 -0.33 1.35e-9 Adiponectin levels; CRC cis rs644799 0.544 rs1727165 chr11:95521648 A/G cg25622487 chr11:95524042 FAM76B;CEP57 0.58 8.69 0.43 1.78e-16 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs7216064 0.953 rs9890629 chr17:65871559 G/A cg12091567 chr17:66097778 LOC651250 -0.61 -7.7 -0.39 1.58e-13 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CRC cis rs9322193 0.923 rs9404048 chr6:149937324 C/T cg07701084 chr6:150067640 NUP43 0.52 7.64 0.39 2.44e-13 Lung cancer; CRC cis rs11971779 0.616 rs6944244 chr7:139051186 T/C cg07862535 chr7:139043722 LUC7L2 0.57 7.35 0.38 1.61e-12 Diisocyanate-induced asthma; CRC cis rs10504229 1.000 rs61733801 chr8:58192513 A/G cg05313129 chr8:58192883 C8orf71 -0.47 -6.99 -0.36 1.49e-11 Developmental language disorder (linguistic errors); CRC cis rs4713118 0.615 rs9348772 chr6:27656090 G/T cg15845792 chr6:28175446 NA 0.55 7.82 0.4 7e-14 Parkinson's disease; CRC cis rs2243480 0.908 rs1532573 chr7:65798802 A/G cg25985355 chr7:65971099 NA 0.52 5.83 0.31 1.31e-8 Diabetic kidney disease; CRC cis rs2204008 0.775 rs12369238 chr12:38176051 A/G cg26384229 chr12:38710491 ALG10B 0.65 9.08 0.45 1.06e-17 Bladder cancer; CRC cis rs561341 1.000 rs483301 chr17:30293398 G/T cg12193833 chr17:30244370 NA -0.75 -8.72 -0.43 1.4e-16 Hip circumference adjusted for BMI; CRC cis rs9399137 0.507 rs7761964 chr6:135314265 T/C cg22676075 chr6:135203613 NA 0.59 9.01 0.45 1.66e-17 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; CRC cis rs2952156 0.920 rs2517954 chr17:37843550 T/C cg20243544 chr17:37824526 PNMT 0.56 8.61 0.43 2.97e-16 Asthma; CRC cis rs68170813 0.559 rs1018947 chr7:106851939 A/T cg02696742 chr7:106810147 HBP1 -0.63 -7.08 -0.36 8.79e-12 Coronary artery disease; CRC cis rs12549902 0.871 rs4736819 chr8:41509915 C/T cg17182837 chr8:41585554 ANK1 -0.37 -5.75 -0.3 2.03e-8 Corrected insulin response;Corrected insulin response adjusted for insulin sensitivity index;Insulin levels adjusted for BMI;Type 2 diabetes; CRC cis rs59918340 0.764 rs4961256 chr8:142229946 G/A cg17298326 chr8:142245477 NA -0.37 -5.71 -0.3 2.55e-8 Immature fraction of reticulocytes; CRC cis rs17401966 0.931 rs11121545 chr1:10411211 A/G cg19773385 chr1:10388646 KIF1B -0.68 -11.05 -0.52 2.41e-24 Hepatocellular carcinoma; CRC cis rs921968 0.541 rs549026 chr2:219339283 T/C cg02176678 chr2:219576539 TTLL4 0.54 8.69 0.43 1.78e-16 Mean corpuscular hemoglobin concentration; CRC cis rs4862307 0.836 rs13107384 chr4:185004073 C/T cg06737308 chr4:185021514 ENPP6 -0.44 -6.99 -0.36 1.5e-11 Serum dimethylarginine levels (asymmetric/symetric ratio); CRC cis rs7524258 0.868 rs4908610 chr1:7311260 C/A cg07173049 chr1:7289937 CAMTA1 0.59 9.66 0.47 1.3e-19 Tourette's syndrome or obsessive-compulsive disorder; CRC cis rs1451375 0.583 rs11575320 chr7:50605298 A/G cg18232548 chr7:50535776 DDC -0.46 -6.3 -0.33 9.42e-10 Malaria; CRC cis rs7959452 0.590 rs10878974 chr12:69781528 C/G cg20891283 chr12:69753455 YEATS4 0.91 17.31 0.69 3.38e-48 Blood protein levels; CRC cis rs1395 0.778 rs2580759 chr2:27432500 G/T cg14242246 chr2:27434262 C2orf28;SLC5A6 -0.37 -6.88 -0.35 3.03e-11 Blood metabolite levels; CRC cis rs2996428 0.561 rs2275833 chr1:3745721 C/T cg22529645 chr1:3704559 LRRC47 0.43 5.81 0.3 1.5e-8 Red cell distribution width; CRC cis rs6834538 0.538 rs6812859 chr4:113414100 A/C cg10021238 chr4:113569128 MIR367;LARP7 -0.37 -5.77 -0.3 1.81e-8 Free thyroxine concentration; CRC trans rs4591358 0.689 rs72927784 chr2:196415053 C/T cg12742475 chr15:75233485 NA 0.3 5.96 0.31 6.4e-9 Adverse response to chemotherapy (neutropenia/leucopenia) (all antimicrotubule drugs); CRC cis rs1555895 0.544 rs1555897 chr10:853674 A/C cg10556349 chr10:835070 NA -0.35 -6.69 -0.35 9.81e-11 Survival in rectal cancer; CRC cis rs600806 0.888 rs10745352 chr1:109871787 T/C cg23032129 chr1:109941072 SORT1 -0.28 -6.1 -0.32 3.05e-9 Intelligence (multi-trait analysis); CRC cis rs2878628 0.596 rs57039206 chr3:52758570 T/A cg18404041 chr3:52824283 ITIH1 -0.4 -8.34 -0.42 2.1e-15 Intelligence (multi-trait analysis); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg10457504 chr17:19281708 MAPK7 0.45 6.46 0.34 3.72e-10 Response to antipsychotic treatment; CRC cis rs9894429 0.966 rs6565601 chr17:79580173 C/T cg18240062 chr17:79603768 NPLOC4 0.56 9.34 0.46 1.54e-18 Eye color traits; CRC cis rs1448094 0.512 rs7134732 chr12:86241908 T/C cg18827107 chr12:86230957 RASSF9 -0.45 -7.42 -0.38 9.97e-13 Major depressive disorder; CRC cis rs4713118 0.669 rs200997 chr6:27811815 G/A cg25164649 chr6:28176230 NA 0.56 7.88 0.4 4.81e-14 Parkinson's disease; CRC cis rs17065868 0.764 rs9533859 chr13:45032951 A/G cg10246903 chr13:45222710 NA 0.54 5.69 0.3 2.79e-8 Antineutrophil cytoplasmic antibody-associated vasculitis; CRC cis rs7647973 0.710 rs1532204 chr3:49609477 C/G cg03060546 chr3:49711283 APEH 0.66 7.37 0.38 1.41e-12 Menarche (age at onset); CRC cis rs3749237 0.595 rs4955412 chr3:49418168 A/C cg03060546 chr3:49711283 APEH 0.6 10.25 0.49 1.36e-21 Resting heart rate; CRC trans rs9583531 0.689 rs6492308 chr13:111377829 T/C cg20064139 chr20:41823021 NA -0.29 -6.09 -0.32 3.07e-9 Coronary artery disease; CRC cis rs2839186 0.656 rs8128380 chr21:47665693 C/T cg02776659 chr21:47717406 C21orf57 -0.34 -5.75 -0.3 2.03e-8 Testicular germ cell tumor; CRC cis rs12580194 0.593 rs12581060 chr12:55797484 A/C cg19537932 chr12:55886519 OR6C68 -0.73 -9.21 -0.45 3.8e-18 Cancer; CRC cis rs68170813 0.559 rs78079372 chr7:106934548 T/G cg02696742 chr7:106810147 HBP1 -0.62 -6.96 -0.36 1.8e-11 Coronary artery disease; CRC cis rs56399783 0.901 rs12540539 chr7:2873294 C/T cg19731401 chr7:2775893 GNA12 0.61 6.47 0.34 3.56e-10 Childhood ear infection; CRC cis rs142483589 1 rs142483589 chr9:139320323 CCG/C cg13611204 chr9:139324423 INPP5E -0.42 -5.92 -0.31 7.9e-9 White blood cell count; CRC cis rs4731207 0.596 rs12537431 chr7:124586556 G/A cg23710748 chr7:124431027 NA -0.38 -6.08 -0.32 3.35e-9 Cutaneous malignant melanoma; CRC cis rs1707322 1.000 rs11211222 chr1:46367757 T/C cg03146154 chr1:46216737 IPP 0.51 7.16 0.37 5.35e-12 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs7584330 0.554 rs74001386 chr2:238425333 T/A cg08992911 chr2:238395768 MLPH 0.47 5.76 0.3 1.9e-8 Prostate cancer; CRC cis rs7918232 0.941 rs1753413 chr10:27397112 T/C cg14442939 chr10:27389572 ANKRD26 0.82 8.98 0.44 2.19e-17 Breast cancer; CRC cis rs4268898 1.000 rs6707781 chr2:24441883 T/G cg06627628 chr2:24431161 ITSN2 0.5 7.58 0.39 3.65e-13 Asthma; CRC cis rs72781680 0.561 rs72783615 chr2:24296397 C/A cg20701182 chr2:24300061 SF3B14 0.65 7.6 0.39 3.17e-13 Lymphocyte counts; CRC cis rs9768139 0.708 rs896780 chr7:158113972 C/T cg23298862 chr7:158159286 PTPRN2 0.37 5.82 0.31 1.43e-8 Calcium levels; CRC cis rs853679 0.569 rs9348798 chr6:28143011 G/A cg23161317 chr6:28129485 ZNF389 0.54 6.47 0.34 3.49e-10 Depression; CRC cis rs7107174 1.000 rs11237480 chr11:78110385 C/A cg12700464 chr11:78128424 GAB2 -0.47 -5.68 -0.3 3.03e-8 Testicular germ cell tumor; CRC cis rs7647973 0.580 rs12629759 chr3:49237394 T/C cg06212747 chr3:49208901 KLHDC8B 0.38 5.72 0.3 2.4e-8 Menarche (age at onset); CRC cis rs1124376 0.935 rs6550307 chr3:20097885 G/A cg05072819 chr3:20081367 KAT2B 0.57 6.85 0.35 3.61e-11 Bipolar disorder and schizophrenia; CRC cis rs2380220 0.640 rs9320386 chr6:95994955 T/C cg04719120 chr6:96025338 MANEA 0.64 7.34 0.38 1.71e-12 Behavioural disinhibition (generation interaction); CRC trans rs1814175 0.645 rs28478790 chr11:50054322 C/A cg03929089 chr4:120376271 NA -0.89 -16.04 -0.66 3.41e-43 Height; CRC cis rs2050392 0.737 rs7898978 chr10:30699800 T/C cg25182066 chr10:30743637 MAP3K8 0.45 6.12 0.32 2.59e-9 Inflammatory bowel disease; CRC cis rs2411233 1.000 rs8028720 chr15:39270787 C/G cg23129342 chr15:39283510 NA 0.31 5.69 0.3 2.8e-8 Platelet count; CRC cis rs9916302 0.904 rs11078897 chr17:37415870 C/T cg00129232 chr17:37814104 STARD3 -0.53 -7.89 -0.4 4.57e-14 Glomerular filtration rate (creatinine); CRC cis rs9311474 0.652 rs352158 chr3:52217704 C/T cg08222913 chr3:52553049 STAB1 -0.33 -6.15 -0.32 2.31e-9 Electroencephalogram traits; CRC cis rs3768617 0.510 rs3768620 chr1:183092237 G/A ch.1.3577855R chr1:183094577 LAMC1 0.89 15.86 0.66 1.84e-42 Fuchs's corneal dystrophy; CRC cis rs11098499 0.863 rs11731756 chr4:120478696 T/G cg09307838 chr4:120376055 NA 0.67 9.99 0.48 1.1e-20 Corneal astigmatism; CRC cis rs12048904 0.619 rs10783153 chr1:101328230 T/C cg15686842 chr1:101360669 SLC30A7;EXTL2 0.6 8.11 0.41 9.79e-15 Multiple sclerosis; CRC cis rs9733 0.596 rs72702556 chr1:150680115 C/T cg18016565 chr1:150552671 MCL1 0.45 6.52 0.34 2.57e-10 Tonsillectomy; CRC cis rs3767633 0.925 rs4579731 chr1:161766859 G/A cg09175582 chr1:161736000 ATF6 0.66 6.13 0.32 2.58e-9 IgG glycosylation; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg24356321 chr1:186344702 TPR;C1orf27;MIR548F1 0.41 6.16 0.32 2.13e-9 Intelligence (multi-trait analysis); CRC cis rs4920343 0.710 rs638256 chr1:19091182 C/A cg19637330 chr1:19110922 NA 0.39 5.76 0.3 1.88e-8 Knee osteoarthritis; CRC trans rs9585327 0.584 rs4772260 chr13:100645723 A/G cg06964912 chr1:1173622 NA 0.25 6.03 0.32 4.41e-9 Myopia; CRC cis rs910316 0.763 rs1548807 chr14:75479582 T/G cg08847533 chr14:75593920 NEK9 0.85 15.03 0.64 3.23e-39 Height; CRC cis rs6582630 0.519 rs11181998 chr12:38439970 C/A cg13010199 chr12:38710504 ALG10B 0.47 6.32 0.33 8.32e-10 Drug-induced liver injury (flucloxacillin); CRC cis rs12936587 0.777 rs12951347 chr17:17534513 C/G cg24612305 chr17:17875800 TOM1L2;LRRC48 -0.43 -5.69 -0.3 2.74e-8 Hip circumference;Coronary artery disease or large artery stroke;Coronary heart disease;Coronary artery disease; CRC cis rs1552244 0.626 rs2886396 chr3:10037670 C/T cg02579736 chr3:10068473 FANCD2;CIDECP 0.93 12.04 0.55 6.69e-28 Alzheimer's disease; CRC cis rs10979 1.000 rs6570566 chr6:143899534 G/A cg25407410 chr6:143891975 LOC285740 -0.8 -12.64 -0.57 3.93e-30 Hypospadias; CRC cis rs4862750 0.758 rs2375915 chr4:187896255 A/C cg06074448 chr4:187884817 NA -0.6 -11.28 -0.53 3.75e-25 Lobe attachment (rater-scored or self-reported); CRC cis rs12950390 0.853 rs11658511 chr17:45856918 T/C cg24803719 chr17:45855879 NA -0.32 -6.98 -0.36 1.65e-11 IgG glycosylation; CRC cis rs3126085 0.877 rs1969019 chr1:152211502 A/C cg09127314 chr1:152161683 NA 0.47 6.02 0.31 4.75e-9 Atopic dermatitis; CRC cis rs34375054 0.525 rs7133864 chr12:125606180 C/T cg02766259 chr12:125626809 AACS -0.45 -8.44 -0.42 1.01e-15 Post bronchodilator FEV1/FVC ratio; CRC cis rs11677370 0.603 rs11696104 chr2:3849512 C/G cg17052675 chr2:3827356 NA -0.65 -10.71 -0.51 3.62e-23 Type 2 diabetes; CRC cis rs853679 0.723 rs1736904 chr6:28219270 G/A cg15845792 chr6:28175446 NA 0.74 8.78 0.44 9.29e-17 Depression; CRC cis rs939584 1.000 rs35628463 chr2:653581 G/A cg03610516 chr2:642275 NA -0.41 -5.64 -0.3 3.59e-8 Body mass index; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg12580275 chr1:205744413 RAB7L1 0.47 6.63 0.34 1.4e-10 Response to antipsychotic treatment; CRC cis rs1971762 0.563 rs11170645 chr12:54079080 G/T cg06632207 chr12:54070931 ATP5G2 0.41 7.12 0.37 6.7e-12 Height; CRC cis rs4713118 0.824 rs13211701 chr6:27750079 T/C cg15845792 chr6:28175446 NA 0.68 8.92 0.44 3.35e-17 Parkinson's disease; CRC cis rs7552404 0.727 rs4949677 chr1:76266662 T/A cg10523679 chr1:76189770 ACADM 0.69 8.84 0.44 6.12e-17 Blood metabolite levels;Acylcarnitine levels; CRC cis rs11622475 1.000 rs34964872 chr14:104448435 T/A cg20488157 chr14:104394430 TDRD9 0.67 9.84 0.48 3.34e-20 Bipolar disorder; CRC cis rs4700695 0.764 rs251327 chr5:65269464 A/G cg21114390 chr5:65439923 SFRS12 0.59 7.24 0.37 3.26e-12 Facial morphology (factor 19); CRC cis rs6662572 0.737 rs55652826 chr1:46442678 T/C cg03123370 chr1:45965343 CCDC163P;MMACHC 0.45 5.64 0.3 3.59e-8 Blood protein levels; CRC cis rs3008870 0.755 rs2815365 chr1:67499628 C/T cg08660285 chr1:67390436 MIER1;WDR78 0.57 7.95 0.4 3.1e-14 Lymphocyte percentage of white cells; CRC cis rs7727544 0.904 rs58835386 chr5:131600559 A/G cg14196790 chr5:131705035 SLC22A5 0.33 5.89 0.31 9.57e-9 Blood metabolite levels; CRC cis rs2836974 0.897 rs13049280 chr21:40594656 C/G cg07074390 chr21:40555500 PSMG1 -0.47 -6.29 -0.33 1.03e-9 Cognitive function; CRC cis rs3849570 0.695 rs6792696 chr3:81874009 G/A cg07356753 chr3:81810745 GBE1 -0.6 -8.08 -0.41 1.22e-14 Waist circumference;Body mass index; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg04630321 chr11:74204613 LIPT2 0.44 6.0 0.31 5.22e-9 Anxiety disorder; CRC cis rs4689388 0.926 rs4308429 chr4:6294001 A/G cg25554036 chr4:6271136 WFS1 0.54 8.73 0.43 1.29e-16 Type 2 diabetes and other traits;Type 2 diabetes; CRC cis rs1691799 0.867 rs1027399 chr12:66760942 G/A cg16791601 chr12:66731901 HELB -0.72 -12.66 -0.57 3.39e-30 White blood cell count (basophil); CRC cis rs11229555 0.645 rs12274866 chr11:58177129 C/T cg15696309 chr11:58395628 NA -0.81 -10.45 -0.5 2.9e-22 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; CRC cis rs317689 0.613 rs315112 chr12:69785926 T/A cg14784868 chr12:69753453 YEATS4 0.64 8.81 0.44 7.53e-17 Response to diuretic therapy; CRC cis rs9916302 0.610 rs11078902 chr17:37631883 C/G cg00129232 chr17:37814104 STARD3 -0.53 -7.87 -0.4 5.27e-14 Glomerular filtration rate (creatinine); CRC cis rs1448094 0.512 rs61930861 chr12:86245023 G/T cg00310523 chr12:86230176 RASSF9 0.33 5.62 0.3 3.97e-8 Major depressive disorder; CRC cis rs7917772 0.636 rs2486757 chr10:104535145 C/T cg04362960 chr10:104952993 NT5C2 -0.48 -6.34 -0.33 7.74e-10 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC cis rs2404602 0.647 rs10152247 chr15:76942252 T/G cg23625390 chr15:77176239 SCAPER -0.89 -14.73 -0.63 4.46e-38 Blood metabolite levels; CRC cis rs4285028 0.948 rs1920290 chr3:121672305 A/G cg20356878 chr3:121714668 ILDR1 -0.48 -6.95 -0.36 1.93e-11 Multiple sclerosis; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg02259255 chr5:176944032 DDX41 0.42 6.65 0.34 1.23e-10 Liver disease severity in Alagille syndrome; CRC cis rs2180341 0.842 rs7739679 chr6:127545428 G/A cg24812749 chr6:127587940 RNF146 0.84 10.26 0.49 1.27e-21 Breast cancer; CRC cis rs172166 0.694 rs1631552 chr6:28089699 C/A cg21251018 chr6:28226885 NKAPL 0.46 7.07 0.36 9.53e-12 Cardiac Troponin-T levels; CRC cis rs870825 0.655 rs72703561 chr4:185630890 T/C cg04058563 chr4:185651563 MLF1IP 0.72 9.1 0.45 8.81e-18 Blood protein levels; CRC cis rs1552244 0.938 rs7625049 chr3:10115619 C/T cg13047869 chr3:10149882 C3orf24 0.53 7.44 0.38 8.73e-13 Alzheimer's disease; CRC cis rs1799949 1.000 rs11651341 chr17:41428061 T/C cg01879757 chr17:41196368 BRCA1 -0.44 -6.68 -0.35 9.92e-11 Menopause (age at onset); CRC cis rs9660992 0.573 rs1172161 chr1:205206495 C/T cg21643547 chr1:205240462 TMCC2 -0.38 -6.13 -0.32 2.58e-9 Mean corpuscular volume;Mean platelet volume; CRC cis rs853679 0.517 rs9368552 chr6:28068426 A/G cg15786705 chr6:28176104 NA 0.76 9.6 0.47 2.1e-19 Depression; CRC cis rs76419734 0.510 rs17036102 chr4:106603098 C/T cg24545054 chr4:106630052 GSTCD;INTS12 -0.6 -7.37 -0.38 1.37e-12 Post bronchodilator FEV1; CRC cis rs9399137 0.507 rs7768278 chr6:135274957 T/C cg22676075 chr6:135203613 NA 0.62 9.08 0.45 1.04e-17 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; CRC cis rs1519814 1.000 rs6469902 chr8:121171911 A/T cg22335954 chr8:121166405 COL14A1 -0.55 -6.48 -0.34 3.34e-10 Breast cancer; CRC trans rs637571 0.522 rs12797319 chr11:65735672 G/A cg17712092 chr4:129076599 LARP1B 0.74 12.06 0.55 5.7e-28 Eosinophil percentage of white cells; CRC cis rs2298450 0.717 rs2835330 chr21:37631173 G/A cg02919814 chr21:37666008 DOPEY2 -0.51 -6.75 -0.35 6.68e-11 Schizophrenia; CRC cis rs597539 0.652 rs636049 chr11:68667198 A/C cg06028808 chr11:68637592 NA 0.39 6.29 0.33 1.03e-9 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs912057 0.833 rs1294421 chr6:6743149 A/C cg06612196 chr6:6737390 NA 0.51 8.11 0.41 9.86e-15 Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction); CRC cis rs2032447 0.839 rs199750 chr6:26016462 A/G cg03264133 chr6:25882463 NA 0.5 6.81 0.35 4.78e-11 Intelligence (multi-trait analysis); CRC cis rs5753618 0.583 rs9606843 chr22:31853371 A/C cg22777020 chr22:31556080 RNF185 0.46 5.65 0.3 3.54e-8 Colorectal cancer; CRC cis rs10504229 0.953 rs72652908 chr8:58191324 G/A cg01721255 chr8:58191610 C8orf71 0.49 6.17 0.32 2e-9 Developmental language disorder (linguistic errors); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg18011946 chr5:65440816 SFRS12 0.46 6.37 0.33 6.35e-10 Response to antipsychotic treatment; CRC cis rs7824557 0.564 rs13274106 chr8:11233958 A/G cg20542592 chr8:11973495 FAM66D 0.34 5.9 0.31 8.92e-9 Retinal vascular caliber; CRC cis rs4728302 0.934 rs4129572 chr7:133636888 T/C cg03336402 chr7:133662267 EXOC4 0.46 6.93 0.36 2.21e-11 Intelligence;Intelligence (multi-trait analysis); CRC cis rs17253792 0.822 rs28478195 chr14:56047851 G/A cg24579896 chr14:56047964 C14orf33;KTN1 0.71 6.06 0.32 3.77e-9 Putamen volume; CRC cis rs9911578 0.967 rs2333410 chr17:57137129 G/A cg12560992 chr17:57184187 TRIM37 -0.91 -16.76 -0.68 5.32e-46 Intelligence (multi-trait analysis); CRC cis rs7680126 0.633 rs28378345 chr4:10209897 A/G cg00071950 chr4:10020882 SLC2A9 -0.43 -6.0 -0.31 5.27e-9 Urate levels in lean individuals;Urate levels in overweight individuals;Urate levels in obese individuals; CRC cis rs10857712 0.703 rs12253520 chr10:135235321 C/A cg17796960 chr10:135278976 LOC619207 -0.37 -5.61 -0.3 4.26e-8 Systemic lupus erythematosus; CRC cis rs12142240 0.698 rs17361936 chr1:46862893 C/T cg00530320 chr1:46809349 NSUN4 0.59 8.07 0.41 1.35e-14 Menopause (age at onset); CRC trans rs783540 0.967 rs1145172 chr15:83223616 T/C cg18393722 chr15:85113863 UBE2QP1 -0.39 -6.5 -0.34 3.04e-10 Schizophrenia; CRC cis rs4731207 0.591 rs12535300 chr7:124613907 G/C cg23710748 chr7:124431027 NA -0.39 -6.25 -0.33 1.29e-9 Cutaneous malignant melanoma; CRC cis rs6496667 0.908 rs12592935 chr15:90852437 T/C cg04176472 chr15:90893244 GABARAPL3 0.55 7.4 0.38 1.18e-12 Rheumatoid arthritis; CRC cis rs1552244 1.000 rs33917318 chr3:10067797 T/C cg02579736 chr3:10068473 FANCD2;CIDECP 0.96 12.65 0.57 3.81e-30 Alzheimer's disease; CRC cis rs933688 1.000 rs4382199 chr5:90744228 A/G cg02339078 chr5:90679543 LOC100129716;ARRDC3 0.88 13.58 0.6 1.14e-33 Smoking behavior; CRC cis rs13108904 0.870 rs4974541 chr4:1244037 A/G cg16405210 chr4:1374714 KIAA1530 -0.45 -6.73 -0.35 7.48e-11 Obesity-related traits; CRC trans rs2228479 0.850 rs17226966 chr16:89825338 A/G cg24644049 chr4:85504048 CDS1 0.86 6.93 0.36 2.29e-11 Skin colour saturation; CRC cis rs7243821 0.921 rs1944360 chr18:52623560 C/T cg16669619 chr18:52630472 NA -0.42 -6.09 -0.32 3.12e-9 Chin dimples; CRC cis rs365302 0.716 rs452441 chr6:159610622 C/T cg14500486 chr6:159655392 FNDC1 0.52 7.91 0.4 3.92e-14 Coronary heart disease; CRC cis rs1192419 0.502 rs12059556 chr1:92055995 C/T cg24006770 chr1:92056542 NA 0.57 9.56 0.47 2.97e-19 Optic disc area;Optic nerve measurement (cup-to-disc ratio); CRC cis rs727563 0.593 rs132770 chr22:42017264 A/G cg03806693 chr22:41940476 POLR3H 1.0 10.93 0.52 6.37e-24 Crohn's disease;Inflammatory bowel disease; CRC cis rs2242116 0.796 rs2290546 chr3:46965197 C/G cg27129171 chr3:47204927 SETD2 0.63 9.02 0.45 1.63e-17 Birth weight; CRC cis rs3733585 0.699 rs62294332 chr4:9959989 T/C cg11266682 chr4:10021025 SLC2A9 -0.47 -9.67 -0.47 1.2e-19 Cleft plate (environmental tobacco smoke interaction); CRC cis rs11608355 0.521 rs1119271 chr12:109819727 A/T cg19025524 chr12:109796872 NA -0.57 -9.18 -0.45 4.95e-18 Neuroticism; CRC cis rs7727544 0.571 rs12521097 chr5:131575338 G/A cg04518342 chr5:131593106 PDLIM4 0.35 6.42 0.33 4.62e-10 Blood metabolite levels; CRC cis rs17023223 0.509 rs10923740 chr1:119600287 C/T cg05756136 chr1:119680316 WARS2 -0.5 -6.58 -0.34 1.87e-10 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for BMI in active individuals; CRC cis rs2576037 0.558 rs7244778 chr18:44541915 T/C cg23996704 chr18:44553084 KATNAL2 -0.41 -8.23 -0.41 4.43e-15 Personality dimensions; CRC cis rs2180341 0.782 rs6912196 chr6:127722732 C/G cg24812749 chr6:127587940 RNF146 0.68 9.26 0.45 2.69e-18 Breast cancer; CRC cis rs10751667 0.666 rs10902235 chr11:938892 T/C cg23136738 chr11:925521 AP2A2 -0.42 -6.98 -0.36 1.65e-11 Alzheimer's disease (late onset); CRC cis rs739401 0.611 rs7394974 chr11:3038868 C/T cg05729581 chr11:3078854 CARS -0.61 -9.16 -0.45 5.56e-18 Longevity; CRC cis rs2836950 0.520 rs1980407 chr21:40543961 T/C cg11890956 chr21:40555474 PSMG1 -0.69 -10.48 -0.5 2.33e-22 Menarche (age at onset); CRC cis rs17253792 0.822 rs8007065 chr14:56081272 A/G cg24579896 chr14:56047964 C14orf33;KTN1 0.71 5.69 0.3 2.81e-8 Putamen volume; CRC cis rs9372498 0.536 rs9481808 chr6:118784571 G/A cg15382696 chr6:118971807 C6orf204 0.59 7.5 0.38 6.18e-13 Diastolic blood pressure; CRC cis rs2243480 1.000 rs73142122 chr7:65311298 C/A cg25985355 chr7:65971099 NA -0.5 -5.69 -0.3 2.86e-8 Diabetic kidney disease; CRC cis rs4713118 0.824 rs7759217 chr6:27730463 A/G cg21251018 chr6:28226885 NKAPL 0.41 5.88 0.31 1.02e-8 Parkinson's disease; CRC cis rs561341 1.000 rs56903735 chr17:30254393 T/A cg23018236 chr17:30244563 NA -0.59 -8.03 -0.4 1.76e-14 Hip circumference adjusted for BMI; CRC cis rs4478858 0.647 rs10798835 chr1:31709055 T/C cg00250761 chr1:31883323 NA -0.44 -8.46 -0.42 8.98e-16 Alcohol dependence; CRC cis rs2836974 0.644 rs11088472 chr21:40699376 A/C cg06238570 chr21:40685208 BRWD1 -0.79 -12.51 -0.57 1.22e-29 Cognitive function; CRC cis rs7833986 0.501 rs2719258 chr8:56941389 C/T cg23139584 chr8:56987506 RPS20;SNORD54 0.83 11.64 0.54 1.89e-26 Height; CRC cis rs875971 0.545 rs73378304 chr7:65640747 G/A cg03233332 chr7:66118400 NA -0.4 -5.77 -0.3 1.79e-8 Aortic root size; CRC cis rs9303401 0.538 rs2240259 chr17:56458129 A/C cg10487724 chr17:56770010 TEX14;RAD51C 0.72 8.88 0.44 4.31e-17 Cognitive test performance; CRC cis rs1552244 0.572 rs3894323 chr3:10168967 G/A cg00166722 chr3:10149974 C3orf24 0.66 7.71 0.39 1.49e-13 Alzheimer's disease; CRC cis rs8078723 1.000 rs1042658 chr17:38173902 C/T cg17344932 chr17:38183730 MED24;SNORD124 -0.46 -7.11 -0.36 7.37e-12 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); CRC cis rs853679 0.517 rs17711801 chr6:28092307 C/G cg15845792 chr6:28175446 NA 1.01 13.54 0.6 1.59e-33 Depression; CRC cis rs853679 0.542 rs34131763 chr6:28075000 A/C cg03623178 chr6:28175578 NA 0.95 12.46 0.57 1.93e-29 Depression; CRC cis rs10197940 0.532 rs13425170 chr2:152387112 A/C cg19508488 chr2:152266495 RIF1 0.55 6.9 0.36 2.67e-11 Lung cancer; CRC cis rs2404602 0.552 rs11636612 chr15:76959530 C/T cg23625390 chr15:77176239 SCAPER -0.77 -10.08 -0.49 5.38e-21 Blood metabolite levels; CRC cis rs2836950 0.520 rs59916147 chr21:40634702 T/G cg17971929 chr21:40555470 PSMG1 -0.58 -8.42 -0.42 1.14e-15 Menarche (age at onset); CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg22627950 chr7:44622302 TMED4 0.46 6.0 0.31 5.17e-9 Thyroid stimulating hormone; CRC cis rs4664293 0.669 rs35299907 chr2:160418653 T/C cg08347373 chr2:160653686 CD302 0.38 6.29 0.33 1.01e-9 Monocyte percentage of white cells; CRC cis rs6499255 1.000 rs12446201 chr16:69815586 T/C cg00738113 chr16:70207722 CLEC18C -0.43 -6.36 -0.33 6.77e-10 IgE levels; CRC cis rs1538970 0.962 rs7532762 chr1:45864695 C/A cg05343316 chr1:45956843 TESK2 0.69 9.74 0.47 7.38e-20 Platelet count; CRC cis rs9527 0.615 rs2152915 chr10:104691732 A/T cg04362960 chr10:104952993 NT5C2 0.6 8.59 0.43 3.61e-16 Arsenic metabolism; CRC cis rs524281 0.773 rs2236651 chr11:66001418 C/T cg16950941 chr11:66035639 RAB1B -0.7 -8.04 -0.41 1.67e-14 Electroencephalogram traits; CRC cis rs11229555 0.574 rs11229454 chr11:58203682 T/C cg15696309 chr11:58395628 NA -0.82 -10.31 -0.49 8.59e-22 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; CRC cis rs2836974 0.568 rs377098 chr21:40535216 G/A cg22974920 chr21:40686053 BRWD1 -0.42 -6.0 -0.31 5.34e-9 Cognitive function; CRC cis rs9814567 1.000 rs2056604 chr3:134312648 G/A cg06109529 chr3:134205091 CEP63;ANAPC13 -0.8 -11.7 -0.54 1.13e-26 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs17270561 0.583 rs6937800 chr6:25765943 A/G cg17691542 chr6:26056736 HIST1H1C 0.64 8.14 0.41 8.02e-15 Iron status biomarkers; CRC cis rs66573146 0.831 rs67602077 chr4:7024244 A/G cg15105060 chr4:7024189 TBC1D14 -0.68 -5.85 -0.31 1.21e-8 Granulocyte percentage of myeloid white cells; CRC cis rs4888262 0.526 rs12921903 chr16:74625575 C/T cg01733217 chr16:74700730 RFWD3 0.79 12.09 0.55 4.14e-28 Testicular germ cell tumor; CRC cis rs12477438 0.501 rs13033012 chr2:99795149 T/C cg14399236 chr2:99771627 LIPT1;TSGA10 0.73 12.17 0.56 2.24e-28 Chronic sinus infection; CRC cis rs6502050 0.835 rs8065556 chr17:80091176 G/C cg02741985 chr17:80059408 CCDC57 0.43 7.11 0.36 7.33e-12 Life satisfaction; CRC cis rs9611565 0.659 rs4822034 chr22:41931010 T/C cg06634786 chr22:41940651 POLR3H -0.66 -7.66 -0.39 2.04e-13 Vitiligo; CRC cis rs3733585 0.725 rs6449201 chr4:9973894 C/T cg11266682 chr4:10021025 SLC2A9 -0.46 -9.33 -0.46 1.66e-18 Cleft plate (environmental tobacco smoke interaction); CRC cis rs7923609 0.934 rs10761756 chr10:65172328 C/T cg08743896 chr10:65200160 JMJD1C -0.42 -6.06 -0.32 3.74e-9 Educational attainment;Liver enzyme levels (alkaline phosphatase); CRC cis rs6496667 0.642 rs58218975 chr15:91056798 C/G cg04176472 chr15:90893244 GABARAPL3 0.62 7.87 0.4 5.06e-14 Rheumatoid arthritis; CRC cis rs1552244 1.000 rs4269070 chr3:10126083 C/G cg00166722 chr3:10149974 C3orf24 0.67 9.32 0.46 1.71e-18 Alzheimer's disease; CRC trans rs4263408 0.934 rs9683743 chr4:39703194 A/C cg08264704 chr1:228270414 ARF1 -0.41 -6.09 -0.32 3.11e-9 Plasma amyloid beta peptide concentrations (ABx-40); CRC cis rs7615952 0.599 rs66532274 chr3:125731845 G/A cg06494592 chr3:125709126 NA -0.52 -6.75 -0.35 6.66e-11 Blood pressure (smoking interaction); CRC cis rs13082711 1.000 rs13082711 chr3:27537909 T/C cg02860705 chr3:27208620 NA 0.59 7.58 0.39 3.57e-13 Systolic blood pressure;Diastolic blood pressure;Blood pressure; CRC cis rs13096480 0.583 rs17598137 chr3:49891362 G/T cg11861043 chr3:49131662 QRICH1 0.47 6.9 0.36 2.6e-11 Intelligence (multi-trait analysis); CRC cis rs172166 0.652 rs476167 chr6:28065888 T/C cg02631126 chr6:28058918 ZSCAN12L1 0.24 5.69 0.3 2.82e-8 Cardiac Troponin-T levels; CRC cis rs68170813 0.559 rs7779062 chr7:106880195 T/A cg02696742 chr7:106810147 HBP1 -0.52 -5.87 -0.31 1.05e-8 Coronary artery disease; CRC cis rs947211 0.750 rs5014255 chr1:205753870 C/A cg11965913 chr1:205819406 PM20D1 0.43 6.1 0.32 2.92e-9 Parkinson's disease; CRC cis rs4555082 0.874 rs2816612 chr14:105723103 C/T cg10792982 chr14:105748885 BRF1 0.37 6.03 0.32 4.33e-9 Mean platelet volume;Platelet distribution width; CRC cis rs10504229 1.000 rs72650892 chr8:58179714 A/G cg05313129 chr8:58192883 C8orf71 -0.47 -6.99 -0.36 1.49e-11 Developmental language disorder (linguistic errors); CRC trans rs11654801 0.812 rs11658722 chr17:20858686 G/A cg23759823 chr7:139672531 TBXAS1 -0.39 -6.33 -0.33 8.17e-10 Mosquito bite size; CRC cis rs2742417 0.967 rs1609553 chr3:45735142 T/C cg04837898 chr3:45731254 SACM1L -0.34 -5.63 -0.3 3.95e-8 Response to anti-depressant treatment in major depressive disorder; CRC cis rs7809950 1.000 rs10267907 chr7:107184466 C/T cg23024343 chr7:107201750 COG5 -0.63 -8.81 -0.44 7.27e-17 Coronary artery disease; CRC cis rs2204008 0.744 rs11519905 chr12:38222959 G/A cg26384229 chr12:38710491 ALG10B 0.69 9.19 0.45 4.67e-18 Bladder cancer; CRC cis rs2067615 0.579 rs10861663 chr12:107183589 G/A cg13491945 chr12:107078410 RFX4 0.35 5.94 0.31 7.13e-9 Heart rate; CRC cis rs45509595 0.659 rs390764 chr6:27782535 C/T cg26587870 chr6:27730563 NA -0.6 -5.98 -0.31 5.78e-9 Breast cancer; CRC trans rs10982213 0.830 rs2274163 chr9:117188714 C/T cg04407579 chr13:99228509 STK24 0.39 6.35 0.33 7.14e-10 Interleukin-6 levels; CRC cis rs2239547 0.522 rs6773040 chr3:52935428 C/A cg11645453 chr3:52864694 ITIH4 -0.53 -9.31 -0.46 1.84e-18 Schizophrenia; CRC cis rs10479542 0.784 rs6896940 chr5:178985994 G/C cg00080972 chr5:178986291 RUFY1 0.49 9.93 0.48 1.67e-20 Lung cancer; CRC cis rs9549260 0.564 rs9549279 chr13:41315582 C/G cg21288729 chr13:41239152 FOXO1 -0.42 -6.57 -0.34 1.93e-10 Red blood cell count; CRC cis rs6570726 0.791 rs11155435 chr6:145938545 T/C cg23711669 chr6:146136114 FBXO30 0.75 12.89 0.58 4.55e-31 Lobe attachment (rater-scored or self-reported); CRC cis rs4731207 0.533 rs1481340 chr7:124582051 C/T cg23710748 chr7:124431027 NA -0.38 -6.08 -0.32 3.25e-9 Cutaneous malignant melanoma; CRC trans rs2228479 0.850 rs11641147 chr16:89813589 C/T cg21302420 chr1:112162376 RAP1A 0.72 6.01 0.31 5.05e-9 Skin colour saturation; CRC cis rs9303401 0.659 rs62081314 chr17:56778328 A/G cg10487724 chr17:56770010 TEX14;RAD51C 0.79 10.0 0.48 1.01e-20 Cognitive test performance; CRC cis rs1577917 0.958 rs12215232 chr6:86785430 G/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.55 -6.76 -0.35 6.2e-11 Response to antipsychotic treatment; CRC trans rs916888 0.610 rs199444 chr17:44818276 T/C cg07870213 chr5:140052090 DND1 0.64 8.34 0.42 2.01e-15 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs736801 0.808 rs2248116 chr5:131804347 C/A cg02033258 chr5:131593261 PDLIM4 -0.33 -5.85 -0.31 1.17e-8 Breast cancer;Mosquito bite size; CRC cis rs6952808 0.609 rs6950151 chr7:1953521 T/C cg02951883 chr7:2050386 MAD1L1 -0.53 -8.86 -0.44 5.18e-17 Bipolar disorder and schizophrenia; CRC cis rs57590327 0.508 rs4399914 chr3:81965477 C/T cg07356753 chr3:81810745 GBE1 -0.47 -6.25 -0.33 1.28e-9 Extraversion; CRC cis rs4664293 0.769 rs1365798 chr2:160652364 A/G cg08347373 chr2:160653686 CD302 0.43 6.59 0.34 1.78e-10 Monocyte percentage of white cells; CRC cis rs10504229 0.516 rs60398072 chr8:58086559 G/A cg09858108 chr8:58055024 NA 0.4 6.46 0.34 3.88e-10 Developmental language disorder (linguistic errors); CRC cis rs7605827 0.930 rs763356 chr2:15518816 G/T cg19274914 chr2:15703543 NA 0.39 5.9 0.31 8.92e-9 Educational attainment (years of education); CRC cis rs7799006 0.527 rs2159045 chr7:2207401 T/C cg21782813 chr7:2030301 MAD1L1 0.41 6.62 0.34 1.49e-10 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs8177253 0.828 rs8177259 chr3:133480388 T/C cg08048268 chr3:133502702 NA -0.36 -6.81 -0.35 4.74e-11 Iron status biomarkers; CRC cis rs4865169 0.595 rs9998008 chr4:57766052 A/G cg24291500 chr4:57773398 REST 0.29 5.62 0.3 4.08e-8 Breast cancer; CRC cis rs17065868 0.764 rs61949796 chr13:45030199 T/C cg10246903 chr13:45222710 NA 0.54 5.69 0.3 2.79e-8 Antineutrophil cytoplasmic antibody-associated vasculitis; CRC cis rs8060686 0.545 rs75229939 chr16:68164949 G/A cg26727032 chr16:67993705 SLC12A4 -0.56 -6.19 -0.32 1.8e-9 HDL cholesterol;Metabolic syndrome; CRC trans rs7615952 0.546 rs16836896 chr3:125311262 A/T cg02007433 chr3:129722099 NA -0.51 -6.19 -0.32 1.8e-9 Blood pressure (smoking interaction); CRC cis rs1223397 0.651 rs2496144 chr6:13311941 A/G cg07912922 chr6:13274314 PHACTR1 0.38 6.03 0.32 4.44e-9 Blood pressure; CRC cis rs875971 0.638 rs35986979 chr7:66088990 G/A cg11764359 chr7:65958608 NA -0.54 -8.39 -0.42 1.47e-15 Aortic root size; CRC cis rs7512552 0.525 rs2298161 chr1:150237624 A/G cg15654264 chr1:150340011 RPRD2 0.45 6.58 0.34 1.9e-10 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); CRC cis rs929354 0.772 rs10229630 chr7:157004790 C/T cg16102536 chr7:156981717 UBE3C 0.4 6.72 0.35 7.86e-11 Body mass index; CRC trans rs9634489 0.648 rs4771946 chr13:97062424 C/T cg20945253 chr2:157189510 NR4A2 0.38 6.03 0.32 4.5e-9 Body mass index; CRC cis rs1008375 1.000 rs6811887 chr4:17640858 C/T cg16339924 chr4:17578868 LAP3 0.59 7.93 0.4 3.47e-14 Parasitemia in Tripanosoma cruzi seropositivity; CRC trans rs1455244 0.700 rs7229302 chr18:11508904 G/T cg08720519 chr16:70558200 SF3B3;COG4 0.46 6.81 0.35 4.6e-11 Schizophrenia; CRC cis rs11098499 0.644 rs7676296 chr4:120555687 A/G cg09307838 chr4:120376055 NA 0.6 9.14 0.45 6.54e-18 Corneal astigmatism; CRC cis rs4731207 0.596 rs7795218 chr7:124578380 C/A cg23710748 chr7:124431027 NA -0.39 -6.19 -0.32 1.79e-9 Cutaneous malignant melanoma; CRC cis rs427941 0.703 rs201441 chr7:101737327 A/C cg06246474 chr7:101738831 CUX1 0.45 7.16 0.37 5.44e-12 Plasma omega-3 polyunsaturated fatty acid level (eicosapentaenoic acid); CRC cis rs6089584 1.000 rs6089591 chr20:60570548 A/C cg06108461 chr20:60628389 TAF4 -0.64 -10.37 -0.5 5.29e-22 Body mass index; CRC cis rs477895 1.000 rs7938380 chr11:64034866 G/A cg18375707 chr11:64034959 PLCB3 0.48 6.03 0.32 4.34e-9 Mean platelet volume; CRC cis rs734999 0.967 rs4486391 chr1:2513055 A/T cg18854424 chr1:2615690 NA 0.4 7.55 0.38 4.22e-13 Ulcerative colitis; CRC trans rs16957091 0.528 rs12908349 chr15:43086227 C/T cg07673103 chr8:74277181 NA 0.54 5.97 0.31 6.29e-9 MGMT methylation in smokers; CRC cis rs62064224 0.714 rs11657299 chr17:30634951 G/A cg12855166 chr17:30846586 MYO1D -0.39 -6.57 -0.34 1.92e-10 Schizophrenia; CRC cis rs1691799 0.899 rs1168357 chr12:66749879 T/C cg16791601 chr12:66731901 HELB -0.72 -12.79 -0.58 1.14e-30 White blood cell count (basophil); CRC cis rs67614146 1 rs67614146 chr6:87821827 AC/A cg08069147 chr6:88032118 GJB7;C6orf162 -0.66 -10.14 -0.49 3.41e-21 Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC cis rs1799949 0.965 rs7212284 chr17:41205941 A/G cg19454999 chr17:41278357 BRCA1;NBR2 0.41 6.41 0.33 4.97e-10 Menopause (age at onset); CRC cis rs7089973 0.872 rs11818114 chr10:116634878 G/C cg23260525 chr10:116636907 FAM160B1 0.32 6.81 0.35 4.75e-11 Bipolar disorder or attention deficit hyperactivity disorder; CRC cis rs743757 1.000 rs743857 chr3:50493550 T/C cg09545109 chr3:50388910 TUSC4;CYB561D2 0.44 6.37 0.33 6.54e-10 Diastolic blood pressure; CRC trans rs1005277 0.579 rs1740737 chr10:38499365 G/T cg23533926 chr12:111358616 MYL2 -0.56 -8.42 -0.42 1.21e-15 Extrinsic epigenetic age acceleration; CRC cis rs6502050 0.731 rs12150589 chr17:80158233 A/T cg22110888 chr17:80059540 CCDC57 0.38 6.01 0.31 5.06e-9 Life satisfaction; CRC cis rs4713118 0.824 rs9468223 chr6:27740666 C/T cg25164649 chr6:28176230 NA 0.61 8.13 0.41 9.13e-15 Parkinson's disease; CRC cis rs9311676 0.656 rs11915480 chr3:58377159 A/G cg06643156 chr3:58380774 PXK 0.41 6.35 0.33 7.27e-10 Systemic lupus erythematosus; CRC cis rs9549328 0.765 rs1317506 chr13:113631143 C/T cg24588162 chr13:113633484 MCF2L -0.37 -6.67 -0.35 1.05e-10 Systolic blood pressure; CRC trans rs561341 1.000 rs530715 chr17:30320544 T/G cg20587970 chr11:113659929 NA -1.18 -17.19 -0.69 1.02e-47 Hip circumference adjusted for BMI; CRC cis rs75422866 0.867 rs73104104 chr12:48065769 C/T cg14736327 chr12:48174669 SLC48A1 -0.79 -6.01 -0.31 4.92e-9 Pneumonia; CRC cis rs10540 1.000 rs61876332 chr11:487101 C/T cg08200582 chr11:442649 ANO9 -0.7 -7.07 -0.36 9.14e-12 Body mass index; CRC cis rs17688076 0.511 rs2418738 chr16:68122604 G/C cg26727032 chr16:67993705 SLC12A4 -0.6 -8.12 -0.41 9.45e-15 C-reactive protein levels or HDL-cholesterol levels (pleiotropy); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg10628982 chr1:33816091 PHC2 0.42 6.19 0.32 1.81e-9 Response to antipsychotic treatment; CRC cis rs10911363 0.570 rs2702204 chr1:183457396 A/G cg09173681 chr1:183549694 NCF2 0.73 10.06 0.49 6.14e-21 Systemic lupus erythematosus; CRC cis rs9649213 0.574 rs36099592 chr7:98002331 T/C cg00277769 chr7:97922759 BAIAP2L1 -0.6 -10.39 -0.5 4.76e-22 Prostate cancer (SNP x SNP interaction); CRC cis rs875971 1.000 rs11974264 chr7:65647582 C/G cg11764359 chr7:65958608 NA -0.62 -9.99 -0.48 1.04e-20 Aortic root size; CRC cis rs769267 0.930 rs3794993 chr19:19611550 G/T cg02546618 chr19:19431379 KIAA0892;SF4 0.43 5.93 0.31 7.82e-9 Tonsillectomy; CRC cis rs7089973 0.604 rs35319791 chr10:116602296 C/A cg23260525 chr10:116636907 FAM160B1 0.35 8.11 0.41 1.04e-14 Bipolar disorder or attention deficit hyperactivity disorder; CRC cis rs9928842 0.823 rs6564243 chr16:75296001 A/C cg09066997 chr16:75300724 BCAR1 0.62 5.86 0.31 1.1e-8 Alcoholic chronic pancreatitis; CRC cis rs5750830 0.649 rs5750820 chr22:39825322 T/G cg11247378 chr22:39784982 NA -0.46 -8.83 -0.44 6.17e-17 Intelligence (multi-trait analysis); CRC cis rs7769051 0.522 rs6928933 chr6:133116073 G/A cg07930552 chr6:133119739 C6orf192 0.87 6.92 0.36 2.31e-11 Type 2 diabetes nephropathy; CRC cis rs12545109 0.879 rs2576580 chr8:57365828 G/C cg09654669 chr8:57350985 NA -0.44 -5.86 -0.31 1.12e-8 Obesity-related traits; CRC cis rs9926296 0.605 rs6500453 chr16:89858657 C/G cg27121462 chr16:89883253 FANCA 0.6 9.56 0.47 2.91e-19 Vitiligo; CRC cis rs7937682 1.000 rs7128353 chr11:111538875 A/G cg09085632 chr11:111637200 PPP2R1B -1.02 -21.08 -0.76 5.23e-63 Primary sclerosing cholangitis; CRC cis rs8078723 1.000 rs8078723 chr17:38166879 A/G cg17467752 chr17:38218738 THRA 0.72 11.83 0.55 3.82e-27 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); CRC cis rs3125734 0.633 rs4979754 chr10:64048959 G/A cg19640130 chr10:64028056 RTKN2 -0.35 -5.66 -0.3 3.31e-8 Rheumatoid arthritis; CRC cis rs2625529 0.730 rs7177242 chr15:72184114 A/G cg16672083 chr15:72433130 SENP8 0.44 6.44 0.33 4.35e-10 Red blood cell count; CRC cis rs4363385 0.747 rs4845508 chr1:152968421 G/C cg25856811 chr1:152973957 SPRR3 -0.25 -6.99 -0.36 1.58e-11 Inflammatory skin disease; CRC cis rs6502050 0.835 rs3935128 chr17:80113414 T/C cg13198984 chr17:80129470 CCDC57 0.46 8.16 0.41 6.94e-15 Life satisfaction; CRC trans rs6940638 1.000 rs12215773 chr6:27039233 T/C cg06606381 chr12:133084897 FBRSL1 -0.6 -6.21 -0.32 1.61e-9 Intelligence (multi-trait analysis); CRC cis rs9916302 0.904 rs11867312 chr17:37597748 C/T cg07936489 chr17:37558343 FBXL20 -0.85 -13.35 -0.59 8.55e-33 Glomerular filtration rate (creatinine); CRC cis rs861020 0.606 rs4844903 chr1:210006267 C/T cg09163369 chr1:210001066 C1orf107 0.4 5.75 0.3 2.08e-8 Orofacial clefts; CRC cis rs7635838 0.654 rs347585 chr3:11286220 C/T cg00170343 chr3:11313890 ATG7 0.52 7.72 0.39 1.39e-13 HDL cholesterol; CRC cis rs9322193 0.962 rs7745915 chr6:150155247 C/T cg13206674 chr6:150067644 NUP43 0.57 7.95 0.4 3.01e-14 Lung cancer; CRC cis rs3785574 0.962 rs62077512 chr17:61851435 C/T cg25654072 chr17:61904446 PSMC5;FTSJ3 0.42 5.92 0.31 8.03e-9 Height; CRC cis rs8067545 0.611 rs11653869 chr17:20197586 T/G cg13482628 chr17:19912719 NA -0.48 -7.7 -0.39 1.56e-13 Schizophrenia; CRC cis rs6570726 0.791 rs9373466 chr6:145912016 T/C cg13319975 chr6:146136371 FBXO30 -0.44 -6.44 -0.33 4.17e-10 Lobe attachment (rater-scored or self-reported); CRC cis rs9733 0.596 rs72702580 chr1:150691285 A/T cg18016565 chr1:150552671 MCL1 0.45 6.52 0.34 2.57e-10 Tonsillectomy; CRC cis rs2282802 0.685 rs7717563 chr5:139689968 A/G cg26211634 chr5:139558579 C5orf32 -0.43 -7.37 -0.38 1.41e-12 Intelligence (multi-trait analysis); CRC cis rs13108904 0.935 rs3755920 chr4:1243617 T/C cg23123621 chr4:1343375 KIAA1530 0.36 6.35 0.33 7.02e-10 Obesity-related traits; CRC trans rs4586057 0.812 rs10881841 chr10:92637153 G/A cg26894278 chr13:21016241 CRYL1 0.38 6.34 0.33 7.64e-10 Economic and political preferences (time); CRC cis rs8077889 0.672 rs1230400 chr17:41845451 G/A cg26893861 chr17:41843967 DUSP3 -1.1 -22.43 -0.78 2.87e-68 Triglycerides; CRC cis rs950169 1.000 rs12916348 chr15:84765527 C/T cg17507749 chr15:85114479 UBE2QP1 0.77 11.96 0.55 1.27e-27 Schizophrenia; CRC cis rs9322193 0.736 rs3828701 chr6:150112199 C/T cg13206674 chr6:150067644 NUP43 0.57 8.16 0.41 7.39e-15 Lung cancer; CRC cis rs9650315 0.530 rs35399441 chr8:57089431 A/C cg23139584 chr8:56987506 RPS20;SNORD54 0.45 6.4 0.33 5.2400000000000005e-10 Height; CRC cis rs4713118 0.539 rs510987 chr6:27847517 G/A cg21251018 chr6:28226885 NKAPL 0.53 8.1 0.41 1.05e-14 Parkinson's disease; CRC cis rs7772486 0.566 rs735536 chr6:146036832 A/C cg23711669 chr6:146136114 FBXO30 -0.65 -10.7 -0.51 3.9e-23 Lobe attachment (rater-scored or self-reported); CRC cis rs644799 1.000 rs563653 chr11:95561488 T/G cg25622487 chr11:95524042 FAM76B;CEP57 0.76 11.99 0.55 9.59e-28 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs7659604 0.676 rs4516739 chr4:122699741 G/T cg20573242 chr4:122745356 CCNA2 0.51 7.37 0.38 1.4e-12 Type 2 diabetes; CRC cis rs3824347 0.771 rs10869477 chr9:77652604 A/G cg01251476 chr9:77566080 C9orf40 0.37 5.83 0.31 1.29e-8 Urinary magnesium-to-creatinine ratio; CRC cis rs7044106 0.512 rs7873848 chr9:123354222 C/G cg14255062 chr9:123606675 PSMD5;LOC253039 0.4 6.1 0.32 2.91e-9 Hip circumference adjusted for BMI; CRC cis rs67340775 0.541 rs200968 chr6:27859568 T/C cg03623178 chr6:28175578 NA 0.88 9.24 0.45 3.24e-18 Lung cancer in ever smokers; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg16688911 chr19:46010011 VASP 0.43 5.97 0.31 6.28e-9 Response to antipsychotic treatment; CRC cis rs7542091 0.813 rs2049999 chr1:210031331 A/G cg05527609 chr1:210001259 C1orf107 -0.5 -6.78 -0.35 5.44e-11 Monobrow; CRC cis rs875971 0.638 rs35986979 chr7:66088990 G/A cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.43 -6.4 -0.33 5.41e-10 Aortic root size; CRC cis rs2243480 0.901 rs12530490 chr7:65691647 G/A cg25985355 chr7:65971099 NA 0.51 5.75 0.3 2.08e-8 Diabetic kidney disease; CRC cis rs7552404 0.727 rs5745433 chr1:76333163 T/G cg22875332 chr1:76189707 ACADM 0.54 6.95 0.36 1.98e-11 Blood metabolite levels;Acylcarnitine levels; CRC cis rs7119 0.667 rs907393 chr15:77903447 T/C cg10437265 chr15:77819839 NA -0.49 -8.54 -0.43 5.15e-16 Type 2 diabetes; CRC cis rs10804591 0.848 rs6782700 chr3:129309147 G/A cg21885638 chr3:129306552 PLXND1 -0.55 -6.78 -0.35 5.53e-11 Waist-hip ratio;Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Hip circumference adjusted for BMI;Waist-to-hip ratio adjusted for body mass index; CRC cis rs478304 0.934 rs1193496 chr11:65537556 C/T cg27068330 chr11:65405492 SIPA1 -0.44 -6.63 -0.34 1.37e-10 Acne (severe); CRC cis rs6456156 0.792 rs2039321 chr6:167516299 C/T cg07513332 chr6:167530253 CCR6 0.37 6.27 0.33 1.14e-9 Primary biliary cholangitis; CRC cis rs3026445 0.887 rs10774601 chr12:110879831 T/C cg12870014 chr12:110450643 ANKRD13A 0.38 5.93 0.31 7.53e-9 QT interval; CRC cis rs12541335 0.639 rs7003478 chr8:22201123 A/G cg27266060 chr8:22091797 NA 0.36 5.92 0.31 8.03e-9 Hypertriglyceridemia; CRC cis rs672059 0.934 rs641057 chr1:183156859 A/G ch.1.3577855R chr1:183094577 LAMC1 0.49 7.13 0.37 6.54e-12 Hypertriglyceridemia; CRC cis rs1552244 1.000 rs17032396 chr3:10153559 A/G cg00166722 chr3:10149974 C3orf24 -0.67 -8.89 -0.44 3.98e-17 Alzheimer's disease; CRC cis rs9322193 0.961 rs4870144 chr6:149896676 C/G cg05036130 chr6:150231994 NA 0.27 5.69 0.3 2.85e-8 Lung cancer; CRC cis rs28386778 1.000 rs2955241 chr17:61968113 G/C cg06601766 chr17:61851465 DDX42;CCDC47 0.45 5.93 0.31 7.64e-9 Prudent dietary pattern; CRC cis rs17767392 0.918 rs8007068 chr14:71770710 T/A cg13720639 chr14:72061746 SIPA1L1 -0.53 -6.86 -0.35 3.45e-11 Mitral valve prolapse; CRC cis rs2795502 1.000 rs2795497 chr10:43339475 C/A cg20628663 chr10:43360327 NA -0.69 -10.81 -0.51 1.67e-23 Blood protein levels; CRC cis rs11212617 1.000 rs637064 chr11:108140909 C/T cg14761454 chr11:108092087 ATM;NPAT 0.42 6.29 0.33 1e-9 Response to metformin in type 2 diabetes (glycemic); CRC cis rs720844 0.748 rs71413623 chr2:149324977 A/C cg09247360 chr2:149335327 NA -0.55 -5.98 -0.31 5.77e-9 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs2952156 0.834 rs903503 chr17:37829571 C/A cg00129232 chr17:37814104 STARD3 -0.7 -12.16 -0.56 2.34e-28 Asthma; CRC trans rs8035957 1.000 rs4924273 chr15:38846738 C/G cg16800975 chr8:17434541 PDGFRL -0.5 -6.08 -0.32 3.35e-9 Type 1 diabetes; CRC cis rs736408 0.609 rs62255396 chr3:52782839 C/T cg10712668 chr3:52740153 GLT8D1;SPCS1 0.38 5.62 0.3 3.97e-8 Bipolar disorder; CRC cis rs10463316 0.963 rs4958450 chr5:150739932 A/C cg03212797 chr5:150827313 SLC36A1 -0.41 -6.01 -0.31 4.89e-9 Metabolite levels (Pyroglutamine); CRC cis rs113835537 0.866 rs59566349 chr11:66365994 A/T cg22134325 chr11:66188745 NPAS4 0.4 6.43 0.33 4.38e-10 Airway imaging phenotypes; CRC cis rs6748734 0.857 rs10933638 chr2:241794655 G/A cg04034577 chr2:241836375 C2orf54 -0.35 -7.45 -0.38 8.4e-13 Urinary metabolites; CRC cis rs7945705 0.935 rs2568061 chr11:8886260 A/G cg14711859 chr11:8959438 ASCL3 0.45 7.52 0.38 5.21e-13 Hemoglobin concentration; CRC cis rs7849270 1.000 rs1009242 chr9:131916832 A/G cg13538475 chr9:131942899 NA -0.31 -6.01 -0.31 4.82e-9 Blood metabolite ratios; CRC cis rs9649213 0.555 rs6956686 chr7:97997945 T/C cg21770322 chr7:97807741 LMTK2 0.51 8.3 0.42 2.69e-15 Prostate cancer (SNP x SNP interaction); CRC cis rs17711722 0.565 rs4717276 chr7:65294741 G/T cg00343986 chr7:65444356 GUSB 0.46 6.58 0.34 1.81e-10 Calcium levels; CRC cis rs12620999 0.941 rs62183342 chr2:237979140 C/A cg23555395 chr2:238036564 NA 0.54 8.35 0.42 1.91e-15 Systemic lupus erythematosus; CRC cis rs6500395 0.962 rs3743780 chr16:48647480 A/G cg04672837 chr16:48644449 N4BP1 0.44 6.48 0.34 3.28e-10 Response to tocilizumab in rheumatoid arthritis; CRC cis rs2243480 1.000 rs2460422 chr7:65601505 C/T cg12463550 chr7:65579703 CRCP 0.7 6.48 0.34 3.32e-10 Diabetic kidney disease; CRC cis rs2274273 0.773 rs8012380 chr14:55735010 T/G cg23234261 chr14:55582407 NA -0.3 -5.84 -0.31 1.28e-8 Protein biomarker; CRC cis rs4588572 0.644 rs1159930 chr5:77768943 C/T cg11547950 chr5:77652471 NA 0.52 7.59 0.39 3.37e-13 Triglycerides; CRC cis rs9837602 0.529 rs793458 chr3:99520169 C/T cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G -0.49 -6.48 -0.34 3.26e-10 Breast cancer; CRC cis rs1008375 0.900 rs13101742 chr4:17701297 G/A cg16339924 chr4:17578868 LAP3 -0.49 -5.94 -0.31 7.36e-9 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs6662572 1.000 rs6662572 chr1:46146812 A/G cg08644498 chr1:46502608 NA 0.48 7.04 0.36 1.13e-11 Blood protein levels; CRC cis rs1707322 0.758 rs10789474 chr1:46250040 G/T cg03146154 chr1:46216737 IPP 0.62 8.95 0.44 2.59e-17 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs9660180 0.967 rs12034740 chr1:1728969 C/A cg03396347 chr1:1875803 NA -0.6 -9.44 -0.46 6.93e-19 Body mass index; CRC cis rs12580194 1.000 rs58332180 chr12:55711353 C/A cg19537932 chr12:55886519 OR6C68 -0.6 -8.23 -0.41 4.29e-15 Cancer; CRC cis rs4689388 0.856 rs10016157 chr4:6294414 T/C cg00701064 chr4:6280414 WFS1 0.75 13.24 0.59 2.21e-32 Type 2 diabetes and other traits;Type 2 diabetes; CRC cis rs7814319 1.000 rs7814319 chr8:97263418 C/T cg20787634 chr8:97240163 UQCRB -0.57 -9.93 -0.48 1.73e-20 Lung function (FVC); CRC cis rs35883536 0.647 rs2783696 chr1:101044089 G/A cg06223162 chr1:101003688 GPR88 0.37 6.75 0.35 6.64e-11 Monocyte count; CRC cis rs4423214 0.840 rs1540127 chr11:71179038 G/A cg13043300 chr11:71146211 DHCR7 -0.44 -5.96 -0.31 6.39e-9 Vitamin D levels; CRC cis rs9733 0.566 rs112967224 chr1:150677263 G/A cg15448220 chr1:150897856 SETDB1 0.46 6.53 0.34 2.55e-10 Tonsillectomy; CRC trans rs11148252 0.774 rs9596649 chr13:52934610 A/G cg18335740 chr13:41363409 SLC25A15 -0.56 -8.96 -0.44 2.5e-17 Lewy body disease; CRC cis rs9291683 0.597 rs11722989 chr4:10126139 A/G cg11266682 chr4:10021025 SLC2A9 -0.45 -8.78 -0.44 9.13e-17 Bone mineral density; CRC cis rs3733585 0.699 rs60045583 chr4:9971950 G/A cg00071950 chr4:10020882 SLC2A9 -0.55 -9.81 -0.48 4.22e-20 Cleft plate (environmental tobacco smoke interaction); CRC trans rs2797160 1.000 rs2797158 chr6:126009398 G/A cg05039488 chr6:79577232 IRAK1BP1 0.49 7.29 0.37 2.25e-12 Endometrial cancer; CRC cis rs11249608 0.548 rs7733072 chr5:178456007 A/G cg01312482 chr5:178451176 ZNF879 -0.34 -5.66 -0.3 3.35e-8 Pubertal anthropometrics; CRC cis rs7208859 0.673 rs999798 chr17:29158840 A/G cg13385521 chr17:29058706 SUZ12P 0.55 7.35 0.38 1.6e-12 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs9303401 0.659 rs7210700 chr17:56668186 G/A cg02118635 chr17:56770003 RAD51C;TEX14 0.78 9.61 0.47 1.92e-19 Cognitive test performance; CRC cis rs17376456 0.825 rs10052662 chr5:93271385 A/G cg25358565 chr5:93447407 FAM172A 1.11 10.62 0.51 7.72e-23 Diabetic retinopathy; CRC cis rs6499255 0.951 rs10454066 chr16:69699005 A/T cg04110750 chr16:69646130 NFAT5 -0.57 -7.82 -0.4 7.07e-14 IgE levels; CRC cis rs8077889 0.645 rs1230393 chr17:41842592 A/G cg25876840 chr17:41920477 NA -0.46 -7.3 -0.37 2.21e-12 Triglycerides; CRC cis rs1153858 1.000 rs67461176 chr15:45676819 C/T cg21132104 chr15:45694354 SPATA5L1 0.57 8.29 0.42 2.85e-15 Homoarginine levels; CRC cis rs4132509 0.793 rs7522883 chr1:243803022 C/T cg21452805 chr1:244014465 NA 0.59 6.3 0.33 9.66e-10 RR interval (heart rate); CRC cis rs9534288 0.742 rs7337140 chr13:46641481 C/T cg15192986 chr13:46630673 CPB2 0.73 9.45 0.46 6.4e-19 Blood protein levels; CRC cis rs7772486 0.875 rs2073287 chr6:146350264 T/C cg23711669 chr6:146136114 FBXO30 0.62 10.73 0.51 3.1e-23 Lobe attachment (rater-scored or self-reported); CRC cis rs2412459 1.000 rs2279581 chr15:40300092 A/G cg01081584 chr15:40268610 EIF2AK4 -0.62 -6.17 -0.32 2.02e-9 Response to haloperidol in psychosis; CRC cis rs4478858 0.735 rs10798845 chr1:31822636 A/G cg00250761 chr1:31883323 NA 0.42 8.09 0.41 1.17e-14 Alcohol dependence; CRC cis rs4555082 0.830 rs2816614 chr14:105727359 C/T cg10792982 chr14:105748885 BRF1 0.37 6.03 0.32 4.33e-9 Mean platelet volume;Platelet distribution width; CRC cis rs6840360 0.809 rs6846809 chr4:152730201 A/G cg09659197 chr4:152720779 NA -0.44 -9.46 -0.46 5.89e-19 Intelligence (multi-trait analysis); CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg15188491 chr1:146644106 PRKAB2 0.52 6.99 0.36 1.57e-11 Thyroid stimulating hormone; CRC cis rs2032447 0.802 rs12346 chr6:26097046 T/C cg03264133 chr6:25882463 NA -0.47 -6.38 -0.33 6.04e-10 Intelligence (multi-trait analysis); CRC cis rs9549260 0.755 rs1923249 chr13:41143881 C/A cg21288729 chr13:41239152 FOXO1 0.4 6.1 0.32 3.05e-9 Red blood cell count; CRC cis rs208520 1.000 rs12192261 chr6:66985268 A/G cg07460842 chr6:66804631 NA 0.91 11.17 0.52 8.75e-25 Exhaled nitric oxide output; CRC trans rs10504390 0.656 rs78904368 chr8:66553761 C/T cg26403416 chr21:43771339 TFF2 0.59 6.13 0.32 2.49e-9 IgG glycosylation; CRC cis rs10504229 0.593 rs17794451 chr8:58019217 C/T cg22535103 chr8:58192502 C8orf71 -0.64 -7.01 -0.36 1.34e-11 Developmental language disorder (linguistic errors); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg01890681 chr17:635336 FAM57A 0.43 6.37 0.33 6.29e-10 Intelligence (multi-trait analysis); CRC cis rs10504229 0.683 rs2873638 chr8:58114593 G/A cg02290350 chr8:58132656 NA -0.58 -8.24 -0.41 4.09e-15 Developmental language disorder (linguistic errors); CRC cis rs3858526 0.959 rs4758219 chr11:5951846 G/C cg05234568 chr11:5960015 NA -0.58 -8.0 -0.4 2.08e-14 DNA methylation (variation); CRC cis rs11255291 1.000 rs7080828 chr10:7733770 G/A cg00997801 chr10:7671259 ITIH5 0.4 5.86 0.31 1.15e-8 Ovarian reserve; CRC cis rs35306767 0.761 rs12773961 chr10:1013215 C/G cg20503657 chr10:835505 NA 0.92 10.92 0.52 6.74e-24 Eosinophil percentage of granulocytes; CRC cis rs1707322 1.000 rs11211243 chr1:46455433 G/C cg03146154 chr1:46216737 IPP 0.51 7.15 0.37 5.54e-12 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs11212617 0.935 rs4623864 chr11:108051300 A/G cg14761454 chr11:108092087 ATM;NPAT 0.43 6.49 0.34 3.13e-10 Response to metformin in type 2 diabetes (glycemic); CRC cis rs2404602 0.660 rs11852777 chr15:76929792 A/G cg03037974 chr15:76606532 NA -0.52 -7.72 -0.39 1.4e-13 Blood metabolite levels; CRC cis rs992157 0.687 rs35271699 chr2:219117482 G/A cg04731861 chr2:219085781 ARPC2 -0.31 -6.57 -0.34 1.99e-10 Colorectal cancer; CRC cis rs9372498 0.536 rs7356947 chr6:118767920 A/G cg22561889 chr6:118971681 C6orf204 0.53 6.83 0.35 4.16e-11 Diastolic blood pressure; CRC cis rs2878628 0.596 rs57039206 chr3:52758570 T/A cg18099408 chr3:52552593 STAB1 -0.46 -7.76 -0.39 1.07e-13 Intelligence (multi-trait analysis); CRC cis rs6088580 0.601 rs6120668 chr20:33099793 A/G cg24642439 chr20:33292090 TP53INP2 0.39 6.59 0.34 1.73e-10 Glomerular filtration rate (creatinine); CRC cis rs908922 0.676 rs7531317 chr1:152528439 A/C cg09873164 chr1:152488093 CRCT1 0.39 6.57 0.34 1.98e-10 Hair morphology; CRC cis rs7959452 0.562 rs11177630 chr12:69767963 G/C cg20891283 chr12:69753455 YEATS4 0.91 17.37 0.69 2.05e-48 Blood protein levels; CRC cis rs12545109 0.879 rs7845180 chr8:57324431 C/T cg09654669 chr8:57350985 NA 0.45 7.09 0.36 8.29e-12 Obesity-related traits; CRC cis rs7615952 0.576 rs2276729 chr3:125826214 G/A cg04553112 chr3:125709451 NA -0.47 -5.69 -0.3 2.82e-8 Blood pressure (smoking interaction); CRC cis rs10504229 1.000 rs59383954 chr8:58189689 G/A cg22535103 chr8:58192502 C8orf71 -0.82 -12.27 -0.56 9.63e-29 Developmental language disorder (linguistic errors); CRC cis rs1552244 0.882 rs3846168 chr3:9996925 C/T cg00166722 chr3:10149974 C3orf24 0.61 8.27 0.41 3.32e-15 Alzheimer's disease; CRC cis rs3806843 0.771 rs801174 chr5:140112712 C/T cg19875535 chr5:140030758 IK -0.63 -10.27 -0.49 1.2e-21 Depressive symptoms (multi-trait analysis); CRC cis rs3741151 1.000 rs76610873 chr11:73084387 C/T cg17517138 chr11:73019481 ARHGEF17 1.03 8.8 0.44 7.71e-17 GIP levels in response to oral glucose tolerance test (120 minutes); CRC cis rs7568458 0.709 rs56819945 chr2:85755139 C/T cg02493740 chr2:85810744 VAMP5 -0.56 -8.41 -0.42 1.29e-15 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); CRC cis rs13256369 0.802 rs1060107 chr8:8561399 G/T cg06671706 chr8:8559999 CLDN23 0.61 9.04 0.45 1.35e-17 Obesity-related traits; CRC cis rs2011503 1.000 rs1557723 chr19:19443033 A/G cg11584989 chr19:19387371 SF4 -0.46 -5.68 -0.3 2.98e-8 Bipolar disorder; CRC cis rs1150688 1 rs1150688 chr6:28162780 T/C cg25164649 chr6:28176230 NA 0.47 6.93 0.36 2.17e-11 Autism spectrum disorder or schizophrenia; CRC cis rs7666738 0.830 rs7662199 chr4:99019766 G/A cg17366294 chr4:99064904 C4orf37 0.43 7.17 0.37 5.01e-12 Colonoscopy-negative controls vs population controls; CRC cis rs7618915 0.547 rs33967311 chr3:52683864 G/T cg10802521 chr3:52805072 NEK4 -0.58 -8.86 -0.44 4.97e-17 Bipolar disorder; CRC cis rs7737355 0.898 rs4706025 chr5:130913788 T/A cg06307176 chr5:131281290 NA 0.49 6.94 0.36 2.06e-11 Life satisfaction; CRC cis rs11148252 0.846 rs7333451 chr13:53047709 G/A cg02158880 chr13:53174818 NA 0.5 7.51 0.38 5.53e-13 Lewy body disease; CRC cis rs951366 0.617 rs823074 chr1:205774839 T/C cg07167872 chr1:205819463 PM20D1 0.99 17.82 0.7 3.29e-50 Menarche (age at onset); CRC cis rs6088590 1.000 rs12626122 chr20:33425800 A/G cg08999081 chr20:33150536 PIGU 0.5 7.88 0.4 4.7e-14 Coronary artery disease; CRC cis rs1707322 0.721 rs11211165 chr1:46157906 C/T cg06784218 chr1:46089804 CCDC17 0.66 12.41 0.56 2.76e-29 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs2075165 0.901 rs7542045 chr1:156246473 G/C cg20302342 chr1:156215951 PAQR6 0.38 7.23 0.37 3.35e-12 Tonsillectomy; CRC trans rs2898857 0.524 rs11652146 chr17:47422363 G/A cg11430096 chr6:110968061 CDK19 -0.49 -7.46 -0.38 8.01e-13 Cancer; CRC cis rs7811142 0.887 rs4074838 chr7:100032665 G/A cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.19 17.69 0.7 1.13e-49 Platelet count; CRC cis rs6502050 0.805 rs4789720 chr17:80157490 G/C cg19223190 chr17:80058835 NA 0.41 6.7 0.35 8.79e-11 Life satisfaction; CRC cis rs2180341 0.538 rs4392733 chr6:127712603 T/C cg27446573 chr6:127587934 RNF146 0.48 6.98 0.36 1.64e-11 Breast cancer; CRC cis rs2635047 0.684 rs7236105 chr18:44757226 G/T cg19077165 chr18:44547161 KATNAL2 -0.42 -6.1 -0.32 2.94e-9 Educational attainment; CRC cis rs10206020 0.885 rs13411553 chr2:1574018 A/G cg12573674 chr2:1569213 NA -0.76 -10.4 -0.5 4.17e-22 IgG glycosylation; CRC cis rs2019137 0.539 rs6755040 chr2:113981137 T/C cg07594247 chr2:113993304 PAX8;LOC440839;LOC654433 0.49 7.56 0.38 3.99e-13 Lymphocyte counts; CRC trans rs35110281 0.693 rs2838344 chr21:45089877 C/T cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.42 6.84 0.35 3.81e-11 Mean corpuscular volume; CRC cis rs34375054 0.624 rs73233307 chr12:125675873 G/C cg05341575 chr12:125625032 AACS -0.4 -5.74 -0.3 2.14e-8 Post bronchodilator FEV1/FVC ratio; CRC cis rs10503871 0.545 rs6991816 chr8:30487344 C/T cg26383811 chr8:30366931 RBPMS -0.39 -5.67 -0.3 3.08e-8 Metabolite levels (X-11787); CRC trans rs60843830 1.000 rs2126129 chr2:212548 C/T cg11347411 chr7:150020925 ACTR3C;LRRC61 0.58 8.78 0.44 8.93e-17 Spherical equivalent (joint analysis main effects and education interaction); CRC cis rs7224685 1.000 rs7224685 chr17:4014384 G/T cg11204139 chr17:3907470 NA 0.55 8.45 0.42 9.87e-16 Type 2 diabetes; CRC cis rs4664308 0.967 rs17831329 chr2:160915819 T/C cg03641300 chr2:160917029 PLA2R1 -0.76 -12.7 -0.57 2.38e-30 Idiopathic membranous nephropathy; CRC cis rs9814567 0.752 rs6779326 chr3:134330027 C/T cg06109529 chr3:134205091 CEP63;ANAPC13 -0.67 -9.58 -0.47 2.53e-19 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs7264396 0.635 rs6058375 chr20:34531997 T/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.63 -10.48 -0.5 2.34e-22 Total cholesterol levels; CRC cis rs7680126 0.596 rs17198547 chr4:10141419 A/G cg11266682 chr4:10021025 SLC2A9 0.4 5.91 0.31 8.55e-9 Urate levels in lean individuals;Urate levels in overweight individuals;Urate levels in obese individuals; CRC cis rs12926788 0.546 rs200531 chr16:24756172 G/A cg04756594 chr16:24857601 SLC5A11 -0.33 -6.81 -0.35 4.59e-11 Ejection fraction in Tripanosoma cruzi seropositivity; CRC cis rs9303401 0.703 rs9911583 chr17:57210721 A/G cg02118635 chr17:56770003 RAD51C;TEX14 -0.45 -6.89 -0.35 2.92e-11 Cognitive test performance; CRC cis rs1707322 0.686 rs3014236 chr1:46091305 T/C cg03146154 chr1:46216737 IPP -0.66 -9.39 -0.46 1.04e-18 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs7811142 1.000 rs60844404 chr7:100080474 A/T cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.08 15.27 0.64 3.58e-40 Platelet count; CRC cis rs25422 0.887 rs9481844 chr6:118990941 G/A cg15382696 chr6:118971807 C6orf204 0.48 6.52 0.34 2.65e-10 Renal cell carcinoma; CRC cis rs3956705 0.830 rs7811609 chr7:32930597 A/G cg05721444 chr7:32995514 FKBP9 0.43 6.29 0.33 9.83e-10 Red cell distribution width; CRC cis rs9487051 1.000 rs1546723 chr6:109625879 G/A cg01475377 chr6:109611718 NA -0.45 -8.04 -0.41 1.58e-14 Reticulocyte fraction of red cells; CRC cis rs763121 0.819 rs6001205 chr22:39100264 T/A cg06544989 chr22:39130855 UNC84B 0.45 6.92 0.36 2.35e-11 Menopause (age at onset); CRC cis rs2252790 1.000 rs10456907 chr6:116621036 T/C cg18764771 chr6:116381957 FRK 0.22 5.92 0.31 8.17e-9 Fast beta electroencephalogram; CRC cis rs4730250 0.707 rs257378 chr7:106801395 C/G cg02696742 chr7:106810147 HBP1 -0.63 -6.71 -0.35 8.31e-11 Osteoarthritis; CRC cis rs733592 0.560 rs2158515 chr12:48507668 T/C cg24011408 chr12:48396354 COL2A1 -0.46 -6.81 -0.35 4.61e-11 Plateletcrit; CRC trans rs637571 0.510 rs10750772 chr11:65577427 C/T cg17712092 chr4:129076599 LARP1B -0.54 -8.23 -0.41 4.43e-15 Eosinophil percentage of white cells; CRC cis rs7666738 0.830 rs10031751 chr4:98939134 G/A cg17366294 chr4:99064904 C4orf37 0.43 7.32 0.37 1.95e-12 Colonoscopy-negative controls vs population controls; CRC cis rs875971 1.000 rs4718357 chr7:65960878 A/G cg11764359 chr7:65958608 NA 0.63 10.25 0.49 1.39e-21 Aortic root size; CRC cis rs17666538 0.792 rs1669715 chr8:593641 T/C cg07234876 chr8:600039 NA 0.97 9.31 0.46 1.82e-18 IgG glycosylation; CRC cis rs2302729 0.578 rs2302728 chr12:2774668 A/C cg19945202 chr12:2788847 CACNA1C 0.45 7.35 0.38 1.56e-12 Sleep quality; CRC cis rs6998277 1.000 rs34217554 chr8:103646352 T/C cg10187029 chr8:103597600 NA 0.92 11.88 0.55 2.48e-27 Migraine; CRC cis rs760805 0.932 rs1005734 chr1:25262022 C/A cg22509179 chr1:25234806 RUNX3 -0.7 -11.2 -0.53 6.86e-25 Allergic disease (asthma, hay fever or eczema); CRC cis rs35110281 0.805 rs3788062 chr21:44991159 C/T cg04455712 chr21:45112962 RRP1B 0.4 7.91 0.4 4.03e-14 Mean corpuscular volume; CRC trans rs1005277 0.522 rs9418276 chr10:37940116 G/T cg17830980 chr10:43048298 ZNF37B -0.45 -6.88 -0.35 3.08e-11 Extrinsic epigenetic age acceleration; CRC cis rs514406 0.679 rs12563825 chr1:53238324 G/T cg27535305 chr1:53392650 SCP2 0.46 8.31 0.42 2.62e-15 Monocyte count; CRC cis rs995000 0.899 rs1168099 chr1:63122859 C/A cg19896129 chr1:63156450 NA -0.41 -6.36 -0.33 6.93e-10 Triglyceride levels; CRC cis rs2629540 0.889 rs10901808 chr10:126399159 A/C cg08799069 chr10:126477246 METTL10 0.63 8.09 0.41 1.17e-14 Cocaine dependence; CRC trans rs7580658 0.614 rs7585198 chr2:127962635 C/T cg16531660 chr3:141457093 RNF7 -0.41 -6.13 -0.32 2.5e-9 Protein C levels; CRC cis rs262150 0.704 rs2730236 chr7:158765543 C/T cg12590608 chr7:158785262 NA 0.38 6.56 0.34 2.1e-10 Facial morphology (factor 20); CRC cis rs17376456 0.825 rs28610997 chr5:93248374 T/C cg09848695 chr5:92956644 FAM172A;MIR2277 0.69 5.89 0.31 9.66e-9 Diabetic retinopathy; CRC cis rs1448094 0.512 rs7134732 chr12:86241908 T/C cg25456477 chr12:86230367 RASSF9 0.32 5.67 0.3 3.13e-8 Major depressive disorder; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg21652505 chr19:40023540 EID2B -0.47 -7.01 -0.36 1.33e-11 Myopia (pathological); CRC cis rs6860806 0.661 rs6890009 chr5:131580033 G/T cg12564285 chr5:131593104 PDLIM4 0.46 8.78 0.44 8.9e-17 Breast cancer; CRC cis rs2404602 0.716 rs17362383 chr15:76650702 A/G cg00316803 chr15:76480434 C15orf27 -0.35 -5.64 -0.3 3.59e-8 Blood metabolite levels; CRC cis rs10911232 0.560 rs10911221 chr1:183046737 G/C ch.1.3577855R chr1:183094577 LAMC1 0.81 13.64 0.6 7.07e-34 Hypertriglyceridemia; CRC cis rs523522 0.962 rs4767914 chr12:120993817 C/T cg12219531 chr12:120966889 COQ5 0.69 9.2 0.45 4.17e-18 High light scatter reticulocyte count; CRC cis rs6504950 0.679 rs9897646 chr17:52985351 G/C cg26251398 chr17:52985966 TOM1L1 0.4 5.74 0.3 2.1e-8 Breast cancer; CRC cis rs10504229 0.775 rs56155911 chr8:58163247 C/T cg02725872 chr8:58115012 NA -0.59 -9.12 -0.45 7.59e-18 Developmental language disorder (linguistic errors); CRC cis rs7827545 1.000 rs7008121 chr8:135565904 T/C cg17885191 chr8:135476712 NA 0.54 7.42 0.38 1.03e-12 Hypertension (SNP x SNP interaction); CRC cis rs13082711 0.863 rs35998108 chr3:27423427 G/A cg02860705 chr3:27208620 NA 0.59 8.67 0.43 2.06e-16 Systolic blood pressure;Diastolic blood pressure;Blood pressure; CRC cis rs1707322 0.721 rs4660883 chr1:46236098 C/T cg03146154 chr1:46216737 IPP 0.68 9.84 0.48 3.52e-20 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs7633770 0.786 rs1402148 chr3:46678295 C/T cg11219411 chr3:46661640 NA 0.53 8.43 0.42 1.09e-15 Coronary artery disease; CRC cis rs4523957 0.690 rs11078855 chr17:2091308 A/G cg16513277 chr17:2031491 SMG6 0.67 10.79 0.51 1.99e-23 Autism spectrum disorder or schizophrenia;Schizophrenia; CRC cis rs892961 0.932 rs11650011 chr17:75412334 A/G cg05865280 chr17:75406074 SEPT9 0.63 14.52 0.63 2.81e-37 Airflow obstruction; CRC cis rs6973256 0.543 rs13243553 chr7:133506955 A/G cg10665199 chr7:133106180 EXOC4 -0.45 -6.67 -0.35 1.06e-10 Intelligence (multi-trait analysis); CRC cis rs58235267 0.656 rs12713469 chr2:63059927 C/T cg17519650 chr2:63277830 OTX1 -0.48 -7.29 -0.37 2.39e-12 Prostate-specific antigen levels (conditioned on lead SNPs); CRC cis rs720844 0.580 rs13009428 chr2:149296505 C/A cg09247360 chr2:149335327 NA -0.42 -5.7 -0.3 2.62e-8 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs10256972 0.567 rs2949185 chr7:1209013 A/G cg18765753 chr7:1198926 ZFAND2A -0.42 -7.31 -0.37 1.99e-12 Longevity;Endometriosis; CRC cis rs10744422 1.000 rs3852536 chr12:123333824 C/T cg25930673 chr12:123319894 HIP1R -0.6 -6.32 -0.33 8.36e-10 Schizophrenia; CRC cis rs12410462 0.551 rs2814091 chr1:227636367 G/T cg23173402 chr1:227635558 NA 0.41 5.64 0.3 3.63e-8 Major depressive disorder; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg11540624 chr2:232573066 PTMA 0.47 6.58 0.34 1.85e-10 Anxiety disorder; CRC cis rs8067545 0.641 rs2108978 chr17:19861458 C/T cg04132472 chr17:19861366 AKAP10 0.45 7.09 0.36 8.36e-12 Schizophrenia; CRC cis rs9372498 0.536 rs9489442 chr6:118885950 A/C cg15382696 chr6:118971807 C6orf204 0.61 7.88 0.4 4.86e-14 Diastolic blood pressure; CRC cis rs6502050 0.835 rs4789732 chr17:80131382 A/G cg25804541 chr17:80189381 SLC16A3 -0.3 -5.84 -0.31 1.23e-8 Life satisfaction; CRC cis rs9928842 0.765 rs6564222 chr16:75225044 A/G cg09066997 chr16:75300724 BCAR1 0.63 6.0 0.31 5.3e-9 Alcoholic chronic pancreatitis; CRC cis rs1577917 1.000 rs1577917 chr6:86691940 C/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.6 -7.51 -0.38 5.75e-13 Response to antipsychotic treatment; CRC cis rs2013441 1.000 rs9915059 chr17:20177104 G/T cg13482628 chr17:19912719 NA -0.43 -6.28 -0.33 1.05e-9 Obesity-related traits; CRC cis rs17209837 0.920 rs4148817 chr7:87087397 C/G cg00919237 chr7:87102261 ABCB4 -0.49 -6.03 -0.32 4.4e-9 Gallbladder cancer; CRC cis rs7089973 0.836 rs1046492 chr10:116624067 C/T cg03647239 chr10:116582469 FAM160B1 0.42 5.97 0.31 6.18e-9 Bipolar disorder or attention deficit hyperactivity disorder; CRC cis rs9467711 0.659 rs72845428 chr6:26550144 C/T cg08501292 chr6:25962987 TRIM38 0.88 6.11 0.32 2.84e-9 Autism spectrum disorder or schizophrenia; CRC cis rs6496044 0.568 rs6496039 chr15:86061963 A/T cg17133734 chr15:86042851 AKAP13 0.43 6.94 0.36 2.09e-11 Interstitial lung disease; CRC cis rs1862618 0.671 rs2591970 chr5:56232595 T/C cg03609598 chr5:56110824 MAP3K1 0.59 7.87 0.4 5.06e-14 Initial pursuit acceleration; CRC cis rs17685 0.712 rs7794454 chr7:75776010 A/G cg16489192 chr7:75678113 MDH2;STYXL1 0.35 5.63 0.3 3.81e-8 Coffee consumption;Coffee consumption (cups per day); CRC cis rs7618915 0.571 rs12632381 chr3:52607685 G/A cg11645453 chr3:52864694 ITIH4 0.35 6.07 0.32 3.59e-9 Bipolar disorder; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg11901034 chr3:128598214 ACAD9 0.42 6.44 0.33 4.14e-10 Liver disease severity in Alagille syndrome; CRC cis rs2084898 0.506 rs531260 chr11:120050515 C/T cg16005559 chr11:120040616 NA -0.5 -7.21 -0.37 3.85e-12 Stroke (pediatric); CRC cis rs34779708 0.931 rs66887762 chr10:35330577 C/T cg03585969 chr10:35415529 CREM 0.67 8.91 0.44 3.47e-17 Inflammatory bowel disease;Crohn's disease; CRC cis rs11122272 0.735 rs2749716 chr1:231486908 T/C cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.5 -7.43 -0.38 9.36e-13 Hemoglobin concentration; CRC cis rs4662945 0.688 rs62174139 chr2:130202775 G/C cg05903289 chr2:130345205 NA -0.29 -5.74 -0.3 2.18e-8 Response to cytidine analogues (gemcitabine); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg21086878 chr14:90862960 CALM1 0.45 6.86 0.35 3.36e-11 Liver disease severity in Alagille syndrome; CRC cis rs10262624 0.528 rs5029444 chr7:23737795 T/C cg20363699 chr7:23626180 CLK2P 0.36 6.27 0.33 1.14e-9 Schizophrenia; CRC cis rs9326248 0.516 rs6589577 chr11:116749977 C/T cg26566898 chr11:117069891 TAGLN 0.41 5.67 0.3 3.21e-8 Blood protein levels; CRC cis rs10504229 0.683 rs72650849 chr8:58140323 A/G cg22535103 chr8:58192502 C8orf71 -0.7 -9.34 -0.46 1.47e-18 Developmental language disorder (linguistic errors); CRC cis rs10256972 0.591 rs6968988 chr7:1169619 A/G cg18765753 chr7:1198926 ZFAND2A -0.34 -5.92 -0.31 8.28e-9 Longevity;Endometriosis; CRC cis rs4523957 0.893 rs11078019 chr17:2162121 G/A cg16513277 chr17:2031491 SMG6 -0.53 -8.76 -0.43 1.07e-16 Autism spectrum disorder or schizophrenia;Schizophrenia; CRC cis rs3772130 0.962 rs9812137 chr3:121539103 T/G cg20356878 chr3:121714668 ILDR1 0.51 7.99 0.4 2.27e-14 Cognitive performance; CRC cis rs4803468 0.935 rs13346603 chr19:41945837 T/A cg09537434 chr19:41945824 ATP5SL 0.96 17.82 0.7 3.29e-50 Height; CRC cis rs904251 0.797 rs2776878 chr6:37487273 G/A cg01843034 chr6:37503916 NA -0.47 -8.48 -0.42 7.75e-16 Cognitive performance; CRC trans rs711355 0.872 rs785428 chr15:30185192 A/G cg19414016 chr13:113697165 MCF2L -0.42 -6.21 -0.32 1.63e-9 Response to antipsychotic treatment; CRC cis rs17270561 0.943 rs76703022 chr6:25703529 A/C cg17691542 chr6:26056736 HIST1H1C 0.67 7.56 0.38 4e-13 Iron status biomarkers; CRC cis rs262150 0.567 rs2040897 chr7:158803848 C/T cg10570241 chr7:158785291 NA 0.39 6.88 0.35 3e-11 Facial morphology (factor 20); CRC cis rs10876993 0.890 rs1585781 chr12:58056701 T/G cg15848620 chr12:58087721 OS9 -0.65 -9.23 -0.45 3.43e-18 Celiac disease or Rheumatoid arthritis; CRC cis rs9914988 0.943 rs67327562 chr17:27108828 G/A cg12682573 chr17:27188876 MIR451;MIR144 0.58 8.06 0.41 1.41e-14 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs3736485 0.934 rs8036821 chr15:51861646 A/G cg08986416 chr15:51914746 DMXL2 -0.45 -6.56 -0.34 2.12e-10 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs4481887 0.927 rs4405158 chr1:248490647 A/C cg13385794 chr1:248469461 NA 0.38 6.66 0.34 1.14e-10 Common traits (Other); CRC cis rs853679 0.517 rs9380055 chr6:28081629 A/G cg23161317 chr6:28129485 ZNF389 0.54 6.56 0.34 2.12e-10 Depression; CRC cis rs1113500 0.862 rs11185264 chr1:108640506 T/C cg06207961 chr1:108661230 NA 0.39 5.72 0.3 2.34e-8 Growth-regulated protein alpha levels; CRC cis rs9522267 0.535 rs4773392 chr13:112227358 A/G cg14352298 chr13:112236639 NA -0.28 -6.38 -0.33 5.96e-10 Hepatitis; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg13973351 chr11:60928923 VPS37C 0.38 6.39 0.33 5.8e-10 Liver disease severity in Alagille syndrome; CRC cis rs875971 0.862 rs1875057 chr7:65731855 A/G cg18252515 chr7:66147081 NA 0.4 5.71 0.3 2.52e-8 Aortic root size; CRC cis rs10504229 0.775 rs10504228 chr8:58162053 T/G cg11062466 chr8:58055876 NA 0.45 5.82 0.31 1.38e-8 Developmental language disorder (linguistic errors); CRC cis rs1018836 0.663 rs2205152 chr8:91483618 C/T cg16814680 chr8:91681699 NA 0.64 9.59 0.47 2.3e-19 Ejection fraction in Tripanosoma cruzi seropositivity; CRC cis rs597539 0.652 rs668576 chr11:68668208 A/G cg21963583 chr11:68658836 MRPL21 0.63 11.64 0.54 1.89e-26 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg20988798 chr7:75677766 MDH2;STYXL1 0.45 6.84 0.35 3.82e-11 Intelligence (multi-trait analysis); CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg03674076 chr20:524243 CSNK2A1 0.41 6.54 0.34 2.4e-10 Obesity-related traits; CRC cis rs9914988 1.000 rs9916866 chr17:27183155 C/G cg19196414 chr17:27188595 MIR451;MIR144 -0.39 -5.69 -0.3 2.82e-8 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs11252926 0.550 rs10904148 chr10:454551 G/T cg16386425 chr10:429943 DIP2C -0.45 -6.99 -0.36 1.51e-11 Psychosis in Alzheimer's disease; CRC cis rs10911232 0.507 rs10911222 chr1:183047363 G/A ch.1.3577855R chr1:183094577 LAMC1 0.82 14.22 0.62 4.34e-36 Hypertriglyceridemia; CRC cis rs7605827 0.930 rs6723785 chr2:15688314 T/C cg19274914 chr2:15703543 NA 0.39 5.82 0.31 1.4e-8 Educational attainment (years of education); CRC cis rs61996546 0.622 rs45542840 chr15:26866738 C/T cg15066197 chr15:26874202 GABRB3 -0.39 -5.99 -0.31 5.37e-9 Response to methotrexate in juvenile idiopathic arthritis; CRC cis rs6988636 0.579 rs28528232 chr8:124189308 G/A cg27053337 chr8:124217698 FAM83A 0.46 6.99 0.36 1.58e-11 Urinary uromodulin levels; CRC trans rs9354352 0.967 rs9354351 chr6:66696271 G/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.59 8.6 0.43 3.21e-16 Initial pursuit acceleration in psychotic disorders; CRC trans rs10982213 0.830 rs2274163 chr9:117188714 C/T cg10880834 chr17:55927538 MRPS23 0.38 6.03 0.32 4.38e-9 Interleukin-6 levels; CRC cis rs17767392 1.000 rs61991205 chr14:71771921 C/T cg13720639 chr14:72061746 SIPA1L1 -0.53 -6.81 -0.35 4.7e-11 Mitral valve prolapse; CRC cis rs951366 0.764 rs823143 chr1:205743425 A/C cg07157834 chr1:205819609 PM20D1 0.78 12.0 0.55 9.33e-28 Menarche (age at onset); CRC cis rs9303280 0.901 rs12103884 chr17:38045725 C/T cg11212589 chr17:38028394 ZPBP2 0.48 8.89 0.44 4.21e-17 Self-reported allergy; CRC cis rs1799949 1.000 rs3092988 chr17:41201702 C/T cg25072359 chr17:41440525 NA 0.43 6.4 0.33 5.35e-10 Menopause (age at onset); CRC cis rs868036 1.000 rs868036 chr15:68055013 T/A cg05925327 chr15:68127851 NA 0.29 5.62 0.3 3.98e-8 Restless legs syndrome; CRC cis rs9399137 0.507 rs13196486 chr6:135283874 C/G cg24558204 chr6:135376177 HBS1L 0.6 8.9 0.44 3.88e-17 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; CRC cis rs10504229 0.683 rs61364624 chr8:58134339 T/A cg21724239 chr8:58056113 NA 0.49 6.81 0.35 4.75e-11 Developmental language disorder (linguistic errors); CRC cis rs2839186 0.967 rs2839191 chr21:47695395 C/G cg09417038 chr21:47716443 C21orf57 -0.41 -6.75 -0.35 6.54e-11 Testicular germ cell tumor; CRC cis rs7945705 0.934 rs1988709 chr11:8882890 A/T cg21881798 chr11:8931708 C11orf17;ST5 0.68 10.46 0.5 2.64e-22 Hemoglobin concentration; CRC trans rs2470578 0.716 rs2733514 chr3:17323931 A/G cg23235460 chr3:187871625 LPP -0.43 -6.22 -0.32 1.52e-9 Schizophrenia; CRC cis rs9916302 0.904 rs587343 chr17:37440603 C/T cg15445000 chr17:37608096 MED1 -0.41 -8.75 -0.43 1.1e-16 Glomerular filtration rate (creatinine); CRC cis rs7224685 0.501 rs7211478 chr17:3897178 C/T cg21851534 chr17:3907994 ZZEF1 0.37 6.4 0.33 5.35e-10 Type 2 diabetes; CRC cis rs2153535 0.580 rs2143356 chr6:8517675 C/T cg07606381 chr6:8435919 SLC35B3 0.65 10.56 0.5 1.24e-22 Motion sickness; CRC cis rs6582630 0.502 rs1115515 chr12:38279830 C/T cg13010199 chr12:38710504 ALG10B 0.45 5.87 0.31 1.05e-8 Drug-induced liver injury (flucloxacillin); CRC cis rs644799 0.582 rs1727149 chr11:95497171 C/T cg03916912 chr11:95522834 CEP57;FAM76B -0.8 -13.61 -0.6 9.14e-34 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC trans rs4586057 0.812 rs11186360 chr10:92667502 C/A cg26894278 chr13:21016241 CRYL1 0.39 6.47 0.34 3.63e-10 Economic and political preferences (time); CRC cis rs10760158 0.832 rs13292100 chr9:124040997 G/C cg14417974 chr9:124058376 GSN -0.34 -5.84 -0.31 1.26e-8 Pulse pressure; CRC trans rs10982213 0.830 rs2274163 chr9:117188714 C/T cg17437088 chr7:130698670 FLJ43663 0.37 5.96 0.31 6.48e-9 Interleukin-6 levels; CRC cis rs9322193 0.923 rs2184369 chr6:150097817 G/A cg13206674 chr6:150067644 NUP43 0.57 8.14 0.41 8.29e-15 Lung cancer; CRC cis rs780096 0.506 rs1647286 chr2:27714517 A/T cg27432699 chr2:27873401 GPN1 -0.52 -8.01 -0.4 1.99e-14 Total body bone mineral density; CRC cis rs35306767 0.903 rs35567307 chr10:915804 G/C cg26597838 chr10:835615 NA 0.98 12.1 0.55 3.94e-28 Eosinophil percentage of granulocytes; CRC cis rs7044106 0.791 rs10984994 chr9:123478769 A/T cg14255062 chr9:123606675 PSMD5;LOC253039 -0.44 -6.42 -0.33 4.71e-10 Hip circumference adjusted for BMI; CRC cis rs780096 0.546 rs1528533 chr2:27595756 G/C cg21248554 chr2:27665150 KRTCAP3 -0.33 -7.58 -0.39 3.52e-13 Total body bone mineral density; CRC cis rs7208859 0.623 rs11657990 chr17:29124200 C/T cg13385521 chr17:29058706 SUZ12P 0.73 8.38 0.42 1.53e-15 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs4664293 0.647 rs7587700 chr2:160444320 T/C cg08347373 chr2:160653686 CD302 -0.38 -6.48 -0.34 3.42e-10 Monocyte percentage of white cells; CRC cis rs12594515 0.967 rs11856523 chr15:45989495 C/T cg19682013 chr15:45996608 NA 0.32 6.7 0.35 9.09e-11 Waist circumference;Weight; CRC trans rs7615952 0.932 rs13314869 chr3:125644669 G/A cg07211511 chr3:129823064 LOC729375 -1.06 -17.67 -0.7 1.31e-49 Blood pressure (smoking interaction); CRC cis rs10504229 1.000 rs67039591 chr8:58174553 T/A cg22535103 chr8:58192502 C8orf71 -0.82 -12.27 -0.56 9.63e-29 Developmental language disorder (linguistic errors); CRC cis rs2832191 0.671 rs73346699 chr21:30515529 C/T cg24692254 chr21:30365293 RNF160 -0.58 -8.49 -0.42 7.16e-16 Dental caries; CRC cis rs4689388 0.926 rs11732178 chr4:6292643 G/C cg25554036 chr4:6271136 WFS1 0.51 8.27 0.41 3.33e-15 Type 2 diabetes and other traits;Type 2 diabetes; CRC cis rs6840360 0.967 rs6823423 chr4:152604723 T/C cg09659197 chr4:152720779 NA 0.49 10.43 0.5 3.46e-22 Intelligence (multi-trait analysis); CRC cis rs9467711 0.651 rs1045537 chr6:26096748 G/C cg08501292 chr6:25962987 TRIM38 0.66 6.4 0.33 5.3e-10 Autism spectrum disorder or schizophrenia; CRC cis rs2204008 0.807 rs8186948 chr12:38325101 C/G cg26384229 chr12:38710491 ALG10B 0.67 9.53 0.47 3.52e-19 Bladder cancer; CRC cis rs3733585 0.598 rs28677023 chr4:9958326 C/A cg11266682 chr4:10021025 SLC2A9 -0.47 -9.67 -0.47 1.2e-19 Cleft plate (environmental tobacco smoke interaction); CRC cis rs9868809 0.881 rs2276850 chr3:48669648 G/A cg00383909 chr3:49044727 WDR6 0.77 7.67 0.39 1.98e-13 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; CRC cis rs6500602 0.739 rs4786502 chr16:4537104 T/C cg08645402 chr16:4508243 NA 0.65 11.51 0.54 5.6e-26 Schizophrenia; CRC cis rs4072980 0.545 rs11210870 chr1:38449910 T/C cg04673462 chr1:38461896 NA -0.4 -6.12 -0.32 2.66e-9 Coronary artery disease; CRC cis rs9311474 0.629 rs7636227 chr3:52566682 G/A cg18591801 chr3:52553433 STAB1 -0.31 -6.1 -0.32 2.93e-9 Electroencephalogram traits; CRC cis rs7044106 0.791 rs4837793 chr9:123483621 G/A cg09419670 chr9:123605666 PSMD5;LOC253039 0.79 12.99 0.58 2.01e-31 Hip circumference adjusted for BMI; CRC cis rs3106136 0.901 rs17623135 chr4:95213091 C/T cg11021082 chr4:95130006 SMARCAD1 -0.46 -7.09 -0.36 8.28e-12 Capecitabine sensitivity; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg26072705 chr17:21454773 C17orf51 0.4 6.38 0.33 5.93e-10 Liver disease severity in Alagille syndrome; CRC cis rs6570726 0.620 rs367693 chr6:145815949 G/A cg13319975 chr6:146136371 FBXO30 -0.61 -9.02 -0.45 1.54e-17 Lobe attachment (rater-scored or self-reported); CRC cis rs2710642 0.777 rs2539987 chr2:63142864 A/G cg17519650 chr2:63277830 OTX1 0.44 6.28 0.33 1.06e-9 LDL cholesterol levels;LDL cholesterol; CRC cis rs10461617 0.617 rs6874733 chr5:56069600 A/G cg12311346 chr5:56204834 C5orf35 -0.48 -6.18 -0.32 1.92e-9 Type 2 diabetes; CRC cis rs7617773 0.817 rs6791930 chr3:48329900 A/G cg11946769 chr3:48343235 NME6 0.64 8.85 0.44 5.61e-17 Coronary artery disease; CRC cis rs863345 0.526 rs10908669 chr1:158501938 C/T cg12129480 chr1:158549410 OR10X1 -0.3 -6.27 -0.33 1.12e-9 Pneumococcal bacteremia; CRC cis rs7044106 0.762 rs10760115 chr9:123476952 G/A cg14255062 chr9:123606675 PSMD5;LOC253039 0.47 7.14 0.37 6.14e-12 Hip circumference adjusted for BMI; CRC cis rs2949837 0.581 rs1496499 chr7:45979023 T/G cg21268650 chr7:45961089 IGFBP3 0.38 6.44 0.33 4.3e-10 Sitting height ratio; CRC cis rs3858526 0.874 rs10838879 chr11:5950169 C/T cg05234568 chr11:5960015 NA -0.58 -8.0 -0.4 2.08e-14 DNA methylation (variation); CRC cis rs2976388 0.590 rs3736011 chr8:143817789 G/A cg15511327 chr8:143859410 LYNX1 -0.4 -6.64 -0.34 1.32e-10 Urinary tract infection frequency; CRC cis rs798554 1.000 rs798540 chr7:2764130 G/A cg13628971 chr7:2884303 GNA12 0.51 6.86 0.35 3.51e-11 Height; CRC trans rs61931739 0.500 rs11053236 chr12:34507962 C/G cg26384229 chr12:38710491 ALG10B 0.67 8.88 0.44 4.28e-17 Morning vs. evening chronotype; CRC cis rs3806843 0.648 rs2530233 chr5:140082876 A/G cg26395211 chr5:140044315 WDR55 0.38 5.63 0.3 3.92e-8 Depressive symptoms (multi-trait analysis); CRC cis rs9584850 0.834 rs12869627 chr13:99120452 G/A cg20487152 chr13:99095054 FARP1 0.41 6.04 0.32 4.06e-9 Neuroticism; CRC cis rs9322193 0.884 rs10872648 chr6:150079835 A/G cg04369109 chr6:150039330 LATS1 -0.43 -5.61 -0.3 4.31e-8 Lung cancer; CRC cis rs9443645 0.901 rs4421161 chr6:79564219 A/G cg09184832 chr6:79620586 NA 0.49 9.02 0.45 1.55e-17 Intelligence (multi-trait analysis); CRC cis rs8060686 0.516 rs4567701 chr16:68163662 T/C cg26727032 chr16:67993705 SLC12A4 -0.58 -8.83 -0.44 6.2e-17 HDL cholesterol;Metabolic syndrome; CRC cis rs13108904 0.870 rs4974542 chr4:1250908 A/G cg20887711 chr4:1340912 KIAA1530 0.41 5.86 0.31 1.1e-8 Obesity-related traits; CRC cis rs950169 0.920 rs11637666 chr15:84703874 A/G cg24253500 chr15:84953950 NA 0.39 6.22 0.32 1.54e-9 Schizophrenia; CRC cis rs10504229 0.906 rs73607868 chr8:58172482 T/C cg02725872 chr8:58115012 NA -0.38 -6.43 -0.33 4.44e-10 Developmental language disorder (linguistic errors); CRC cis rs16975963 0.843 rs7254809 chr19:38365695 A/G cg15135657 chr19:38346511 NA -0.42 -5.67 -0.3 3.21e-8 Longevity; CRC trans rs853679 0.882 rs9461432 chr6:28086883 T/C cg06606381 chr12:133084897 FBRSL1 -0.92 -7.56 -0.38 4e-13 Depression; CRC cis rs7107174 1.000 rs2450131 chr11:77944568 A/C cg02023728 chr11:77925099 USP35 0.52 7.58 0.39 3.57e-13 Testicular germ cell tumor; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg06723301 chr22:21213449 SNAP29;PI4KA 0.34 6.05 0.32 3.93e-9 Liver disease severity in Alagille syndrome; CRC cis rs4808199 0.793 rs12459676 chr19:19425141 A/T cg03709012 chr19:19516395 GATAD2A 0.95 10.55 0.5 1.29e-22 Nonalcoholic fatty liver disease; CRC cis rs847577 0.748 rs13221897 chr7:97719699 G/A cg24562669 chr7:97807699 LMTK2 0.76 16.5 0.67 5.36e-45 Breast cancer; CRC cis rs16870629 0.541 rs2334955 chr5:1062444 A/G cg08382946 chr5:1082689 SLC12A7 0.39 5.69 0.3 2.82e-8 QT interval; CRC cis rs9487051 0.768 rs399561 chr6:109524979 G/A cg01475377 chr6:109611718 NA -0.34 -5.93 -0.31 7.68e-9 Reticulocyte fraction of red cells; CRC cis rs7932354 0.528 rs11039074 chr11:47081732 C/T cg03339077 chr11:47165057 C11orf49 0.43 5.95 0.31 6.94e-9 Bone mineral density (hip);Bone mineral density; CRC cis rs1799949 0.930 rs4445938 chr17:41337900 A/C cg23758822 chr17:41437982 NA 0.79 13.54 0.6 1.65e-33 Menopause (age at onset); CRC trans rs8002861 0.870 rs12865116 chr13:44440441 C/G cg12856521 chr11:46389249 DGKZ -0.41 -6.7 -0.35 9.14e-11 Leprosy; CRC cis rs11098499 0.754 rs2036857 chr4:120249240 T/C cg24375607 chr4:120327624 NA 0.47 7.59 0.39 3.42e-13 Corneal astigmatism; CRC cis rs5753618 0.583 rs2273251 chr22:31843567 G/C cg07713946 chr22:31675144 LIMK2 0.38 5.78 0.3 1.75e-8 Colorectal cancer; CRC cis rs4474465 0.790 rs10751295 chr11:78266047 T/A cg27205649 chr11:78285834 NARS2 0.5 6.41 0.33 5.05e-10 Alzheimer's disease (survival time); CRC cis rs1784581 0.851 rs1784591 chr6:162388893 C/G cg17173639 chr6:162384350 PARK2 -0.84 -15.15 -0.64 1.07e-39 Itch intensity from mosquito bite; CRC cis rs2032447 0.839 rs6901039 chr6:26000885 A/C cg17691542 chr6:26056736 HIST1H1C 0.4 5.61 0.3 4.39e-8 Intelligence (multi-trait analysis); CRC cis rs6860806 0.661 rs28472559 chr5:131581611 G/A cg04518342 chr5:131593106 PDLIM4 0.44 8.21 0.41 4.93e-15 Breast cancer; CRC trans rs1814175 0.817 rs10769617 chr11:49810421 G/A cg15704280 chr7:45808275 SEPT13 -1.0 -19.77 -0.74 7.1e-58 Height; CRC cis rs7772486 0.840 rs11155451 chr6:146422524 A/G cg13319975 chr6:146136371 FBXO30 -0.4 -6.02 -0.31 4.7e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs7666738 0.830 rs28417716 chr4:98864859 C/T cg17366294 chr4:99064904 C4orf37 0.41 6.67 0.35 1.08e-10 Colonoscopy-negative controls vs population controls; CRC cis rs5750830 0.597 rs4821889 chr22:39777254 T/C cg24399712 chr22:39784796 NA -0.51 -10.09 -0.49 4.82e-21 Intelligence (multi-trait analysis); CRC cis rs11212617 1.000 rs11212617 chr11:108283161 G/T cg01991180 chr11:108092276 ATM;NPAT 0.42 6.08 0.32 3.27e-9 Response to metformin in type 2 diabetes (glycemic); CRC trans rs8002861 0.905 rs12430629 chr13:44415919 T/A cg17145862 chr1:211918768 LPGAT1 -0.68 -12.54 -0.57 9.62e-30 Leprosy; CRC cis rs7811142 1.000 rs11771419 chr7:99988403 A/G cg00814883 chr7:100076585 TSC22D4 -0.73 -9.28 -0.46 2.33e-18 Platelet count; CRC cis rs11864453 0.713 rs3764312 chr16:72125733 A/C cg23815491 chr16:72088622 HP 0.5 7.6 0.39 3.09e-13 Fibrinogen levels; CRC cis rs7845219 0.544 rs9643350 chr8:95917276 C/A cg16049864 chr8:95962084 TP53INP1 -0.44 -6.72 -0.35 8.17e-11 Type 2 diabetes; CRC cis rs2992756 0.663 rs2992753 chr1:18808292 A/C cg14356550 chr1:18808102 KLHDC7A 0.4 5.96 0.31 6.39e-9 Breast cancer; CRC cis rs7945705 0.818 rs4929916 chr11:8824996 C/T cg12365402 chr11:9010492 NRIP3 0.37 6.27 0.33 1.11e-9 Hemoglobin concentration; CRC cis rs2032447 0.714 rs199725 chr6:25953684 A/G cg12310025 chr6:25882481 NA -0.49 -6.95 -0.36 1.96e-11 Intelligence (multi-trait analysis); CRC cis rs473651 0.935 rs520765 chr2:239354712 C/T cg21699342 chr2:239360505 ASB1 0.59 10.59 0.5 9.88e-23 Multiple system atrophy; CRC cis rs6500602 0.893 rs934888 chr16:4462832 C/T cg08645402 chr16:4508243 NA 0.53 7.49 0.38 6.35e-13 Schizophrenia; CRC cis rs4332037 0.508 rs60238952 chr7:1914350 A/G cg25834613 chr7:1915315 MAD1L1 -0.4 -6.4 -0.33 5.28e-10 Bipolar disorder; CRC cis rs2996428 0.561 rs72640913 chr1:3747023 C/G cg22529645 chr1:3704559 LRRC47 0.43 5.86 0.31 1.11e-8 Red cell distribution width; CRC cis rs2462686 0.930 rs2462687 chr7:45982306 C/T cg15898840 chr7:45960834 IGFBP3 -0.41 -6.26 -0.33 1.23e-9 Major depressive disorder; CRC cis rs9303401 0.734 rs8073316 chr17:57211381 A/T cg10487724 chr17:56770010 TEX14;RAD51C -0.45 -6.48 -0.34 3.32e-10 Cognitive test performance; CRC cis rs2050392 0.590 rs685319 chr10:30719331 G/A cg25182066 chr10:30743637 MAP3K8 -0.46 -6.1 -0.32 2.96e-9 Inflammatory bowel disease; CRC cis rs9584850 0.794 rs17470961 chr13:99135314 A/G cg20487152 chr13:99095054 FARP1 0.41 5.96 0.31 6.44e-9 Neuroticism; CRC trans rs10488031 1.000 rs10488031 chr7:37076854 A/G cg14852736 chr1:3006329 PRDM16 -0.61 -6.42 -0.33 4.74e-10 QT interval; CRC cis rs11148252 0.846 rs13431 chr13:52987477 G/C cg12458913 chr13:53173898 NA 0.52 8.02 0.4 1.88e-14 Lewy body disease; CRC cis rs875971 1.000 rs778726 chr7:65828731 C/T cg12463550 chr7:65579703 CRCP 0.48 6.96 0.36 1.85e-11 Aortic root size; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg26420413 chr1:93250872 EVI5 0.37 6.07 0.32 3.61e-9 Liver disease severity in Alagille syndrome; CRC cis rs501120 0.584 rs7082177 chr10:44698630 G/A cg09554077 chr10:44749378 NA 0.69 7.91 0.4 4.04e-14 Coronary artery disease;Coronary heart disease; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg19596991 chr10:126432951 FAM53B 0.48 6.74 0.35 7.03e-11 Anxiety disorder; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg25903072 chr15:63334703 TPM1 0.4 6.61 0.34 1.59e-10 Liver disease severity in Alagille syndrome; CRC cis rs7552404 1.000 rs437298 chr1:76113770 T/C cg10523679 chr1:76189770 ACADM -0.82 -11.2 -0.53 7.25e-25 Blood metabolite levels;Acylcarnitine levels; CRC cis rs889398 0.771 rs3790080 chr16:69902139 A/G cg00738113 chr16:70207722 CLEC18C -0.37 -6.23 -0.32 1.4e-9 Body mass index; CRC cis rs7201929 0.959 rs35725751 chr16:28845584 C/T cg10436792 chr16:28889110 ATP2A1 0.43 5.72 0.3 2.37e-8 QT interval; CRC cis rs45509595 0.749 rs401763 chr6:27782528 T/C cg15845792 chr6:28175446 NA 0.72 6.15 0.32 2.24e-9 Breast cancer; CRC trans rs3780486 0.846 rs10116966 chr9:33122370 T/A cg20290983 chr6:43655470 MRPS18A 1.15 26.37 0.82 3.86e-83 IgG glycosylation; CRC cis rs6076065 0.651 rs6114085 chr20:23419276 T/A cg11657817 chr20:23433608 CST11 0.44 6.56 0.34 2.11e-10 Facial morphology (factor 15, philtrum width); CRC cis rs10992471 0.528 rs7031567 chr9:95241363 A/G cg14631576 chr9:95140430 CENPP -0.34 -6.27 -0.33 1.1e-9 Visceral adipose tissue/subcutaneous adipose tissue ratio; CRC cis rs7312933 0.702 rs10785333 chr12:42586470 A/G cg11827402 chr12:42719852 PPHLN1;ZCRB1 -0.62 -8.54 -0.43 5.02e-16 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CRC cis rs7833790 0.777 rs6473301 chr8:82691340 A/G cg17211192 chr8:82754475 SNX16 -0.5 -6.22 -0.32 1.55e-9 Diastolic blood pressure; CRC cis rs6424115 0.867 rs11588187 chr1:24145047 T/A cg10978503 chr1:24200527 CNR2 0.48 8.68 0.43 1.93e-16 Immature fraction of reticulocytes; CRC cis rs7615952 0.641 rs2365019 chr3:125808135 T/C cg04553112 chr3:125709451 NA -0.53 -6.09 -0.32 3.2e-9 Blood pressure (smoking interaction); CRC cis rs6674176 0.628 rs4660758 chr1:44424879 A/C cg15962314 chr1:44399869 ARTN 0.3 5.85 0.31 1.18e-8 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Cognitive ability; CRC cis rs6554196 0.895 rs7694422 chr4:55518877 T/A cg18836493 chr4:55524333 KIT -0.34 -5.65 -0.3 3.56e-8 Monocyte count; CRC cis rs7044106 0.762 rs13291660 chr9:123392748 T/C cg09419670 chr9:123605666 PSMD5;LOC253039 0.73 12.12 0.56 3.24e-28 Hip circumference adjusted for BMI; CRC cis rs6764363 0.527 rs4684332 chr3:278420 A/G cg02057681 chr3:285234 CHL1 0.42 7.22 0.37 3.62e-12 Sudden cardiac arrest; CRC cis rs3540 0.921 rs8034050 chr15:91000206 C/T cg04176472 chr15:90893244 GABARAPL3 0.38 6.52 0.34 2.59e-10 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; CRC cis rs3858526 0.833 rs4758184 chr11:5926719 A/G cg13902645 chr11:5959945 NA -0.6 -8.23 -0.41 4.37e-15 DNA methylation (variation); CRC cis rs853679 0.550 rs34477097 chr6:28197186 C/T cg23161317 chr6:28129485 ZNF389 0.47 6.09 0.32 3.14e-9 Depression; CRC cis rs7647973 0.961 rs7626076 chr3:49298139 G/A cg07636037 chr3:49044803 WDR6 0.55 6.44 0.33 4.32e-10 Menarche (age at onset); CRC cis rs875971 0.660 rs7807944 chr7:66087195 C/G cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.43 -6.4 -0.33 5.41e-10 Aortic root size; CRC cis rs2749592 0.918 rs11011388 chr10:38155210 C/T cg25427524 chr10:38739819 LOC399744 0.64 9.28 0.46 2.36e-18 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs2836974 0.897 rs8132419 chr21:40527827 C/T cg06238570 chr21:40685208 BRWD1 0.71 10.1 0.49 4.5e-21 Cognitive function; CRC cis rs12431939 1.000 rs34063246 chr14:51663719 G/C cg23942311 chr14:51606299 NA -0.55 -6.24 -0.33 1.34e-9 Cancer; CRC cis rs1178968 1.000 rs757939 chr7:72778108 T/C cg25889504 chr7:72793014 NA 0.54 6.12 0.32 2.63e-9 Triglyceride levels; CRC cis rs6840360 1.000 rs9998462 chr4:152646548 T/A cg09659197 chr4:152720779 NA 0.51 11.07 0.52 1.96e-24 Intelligence (multi-trait analysis); CRC cis rs459571 0.876 rs2520095 chr9:136919568 A/G cg13789015 chr9:136890014 NCRNA00094 0.43 5.77 0.3 1.83e-8 Platelet distribution width; CRC cis rs6952808 0.689 rs79950306 chr7:2022063 C/G cg20295408 chr7:1910781 MAD1L1 -0.44 -5.9 -0.31 8.86e-9 Bipolar disorder and schizophrenia; CRC cis rs17095355 0.642 rs57822924 chr10:111702078 G/A cg00817464 chr10:111662876 XPNPEP1 -0.58 -7.59 -0.39 3.27e-13 Biliary atresia; CRC cis rs7312933 0.966 rs6582375 chr12:42423185 A/T cg11827402 chr12:42719852 PPHLN1;ZCRB1 0.61 7.68 0.39 1.78e-13 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CRC cis rs329648 0.637 rs34013297 chr11:133774078 C/A cg06067394 chr11:133789110 IGSF9B -0.39 -5.69 -0.3 2.87e-8 Parkinson's disease; CRC cis rs758324 0.898 rs11956351 chr5:131137224 G/A cg06307176 chr5:131281290 NA 0.45 6.59 0.34 1.7e-10 Alzheimer's disease in APOE e4- carriers; CRC trans rs1325195 1.000 rs1325195 chr1:179071756 G/A cg11624085 chr17:8464688 MYH10 -0.39 -6.01 -0.31 4.97e-9 IgE grass sensitization; CRC cis rs754466 0.580 rs2289311 chr10:79565655 G/A cg17075019 chr10:79541650 NA -0.93 -17.29 -0.69 4.36e-48 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs896854 0.654 rs13281625 chr8:95972738 T/C cg16049864 chr8:95962084 TP53INP1 -0.65 -11.83 -0.55 3.9e-27 Type 2 diabetes; CRC cis rs394563 0.559 rs7752555 chr6:149671116 A/G cg16235748 chr6:149772707 ZC3H12D 0.36 6.53 0.34 2.53e-10 Dupuytren's disease; CRC cis rs12497850 0.931 rs7430501 chr3:48890119 C/T cg20833759 chr3:49053208 WDR6;DALRD3 0.53 9.22 0.45 3.73e-18 Parkinson's disease; CRC cis rs1003719 0.762 rs9975361 chr21:38450025 T/C cg10648535 chr21:38446584 PIGP;TTC3 0.53 7.54 0.38 4.76e-13 Eye color traits; CRC cis rs10221833 0.636 rs355876 chr2:165632858 T/G cg03182029 chr2:165697222 COBLL1 0.5 5.79 0.3 1.63e-8 Response to statin therapy; CRC cis rs929354 0.742 rs6459734 chr7:156935454 A/G cg16102536 chr7:156981717 UBE3C 0.4 6.69 0.35 9.57e-11 Body mass index; CRC cis rs7192380 0.756 rs12596945 chr16:69780819 C/A cg00738113 chr16:70207722 CLEC18C 0.46 7.83 0.4 6.56e-14 Sjögren's syndrome; CRC cis rs7647973 1.000 rs62261249 chr3:49594060 T/C cg07636037 chr3:49044803 WDR6 -0.65 -7.36 -0.38 1.45e-12 Menarche (age at onset); CRC cis rs9311474 0.508 rs17052259 chr3:52593138 A/G cg08222913 chr3:52553049 STAB1 -0.34 -6.46 -0.34 3.7e-10 Electroencephalogram traits; CRC cis rs55665837 1.000 rs10832276 chr11:14483274 C/T cg19336497 chr11:14380999 RRAS2 -0.4 -6.76 -0.35 6.26e-11 Vitamin D levels; CRC cis rs2836974 0.568 rs414850 chr21:40543337 A/C cg06238570 chr21:40685208 BRWD1 0.79 12.84 0.58 7.54e-31 Cognitive function; CRC cis rs8044868 0.530 rs2550870 chr16:72070129 C/T cg06172871 chr16:72088244 HP 0.39 5.74 0.3 2.14e-8 Body mass index (change over time) in cancer or chronic obstructive pulmonary disease;Body mass index (change over time) in cancer; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg00003173 chr3:14166750 CHCHD4;TMEM43 0.43 6.38 0.33 5.94e-10 Liver disease severity in Alagille syndrome; CRC cis rs10979 0.597 rs9403514 chr6:143907790 T/C cg25407410 chr6:143891975 LOC285740 -0.62 -8.31 -0.42 2.53e-15 Hypospadias; CRC cis rs826838 1.000 rs826886 chr12:39095797 A/G cg13010199 chr12:38710504 ALG10B 0.39 5.63 0.3 3.89e-8 Heart rate; CRC cis rs3820068 0.705 rs4645983 chr1:15850603 G/A cg27534772 chr1:16042836 PLEKHM2 0.43 7.26 0.37 2.74e-12 Systolic blood pressure; CRC trans rs11039798 0.623 rs7294273 chr11:48705374 T/C cg03929089 chr4:120376271 NA 0.67 6.98 0.36 1.65e-11 Axial length; CRC cis rs4566357 0.615 rs12328878 chr2:227918962 G/A cg11843606 chr2:227700838 RHBDD1 -0.45 -6.85 -0.35 3.65e-11 Coronary artery disease; CRC cis rs9894429 1.000 rs9894429 chr17:79596811 C/T cg18240062 chr17:79603768 NPLOC4 0.56 9.43 0.46 7.75e-19 Eye color traits; CRC cis rs4629710 0.545 rs11755717 chr6:131547028 A/T cg12606694 chr6:131520996 AKAP7 -0.51 -7.86 -0.4 5.44e-14 Multiple myeloma (IgH translocation); CRC trans rs10863936 0.558 rs7522330 chr1:212234104 A/T cg16920991 chr12:100536345 UHRF1BP1L -0.4 -5.96 -0.31 6.41e-9 Height; CRC cis rs10504229 1.000 rs114486414 chr8:58185103 G/A cg02725872 chr8:58115012 NA -0.38 -6.43 -0.33 4.44e-10 Developmental language disorder (linguistic errors); CRC cis rs9303401 0.527 rs34835800 chr17:56764990 G/A cg02118635 chr17:56770003 RAD51C;TEX14 0.76 9.23 0.45 3.39e-18 Cognitive test performance; CRC cis rs11992162 0.636 rs11250182 chr8:11807576 A/T cg00262122 chr8:11665843 FDFT1 -0.37 -5.73 -0.3 2.28e-8 Monocyte count; CRC cis rs2797160 0.904 rs1612274 chr6:126014907 C/A cg05901451 chr6:126070800 HEY2 0.38 5.92 0.31 7.94e-9 Endometrial cancer; CRC cis rs7705042 0.647 rs10051379 chr5:141501662 T/G cg07392085 chr5:141489673 NDFIP1 -0.42 -6.07 -0.32 3.62e-9 Asthma; CRC cis rs7632954 0.900 rs6777857 chr3:8519329 C/T cg03495237 chr3:8533978 NA 0.34 6.14 0.32 2.33e-9 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs490234 0.702 rs13284572 chr9:128258270 T/C cg14078157 chr9:128172775 NA -0.39 -6.33 -0.33 7.91e-10 Mean arterial pressure; CRC cis rs57221529 0.766 rs72706610 chr5:561111 G/A cg14541582 chr5:601475 NA -0.33 -6.45 -0.33 4.09e-10 Lung disease severity in cystic fibrosis; CRC cis rs7301826 0.651 rs1554807 chr12:131280417 C/T cg11011512 chr12:131303247 STX2 -0.38 -5.77 -0.3 1.86e-8 Plasma plasminogen activator levels; CRC cis rs7662987 0.517 rs2851263 chr4:100030354 A/G cg12011299 chr4:100065546 ADH4 0.49 9.27 0.46 2.46e-18 Smoking initiation; CRC cis rs10751667 0.643 rs11246362 chr11:969818 C/T cg06064525 chr11:970664 AP2A2 -0.3 -6.11 -0.32 2.78e-9 Alzheimer's disease (late onset); CRC cis rs1018836 0.632 rs6995399 chr8:91481629 T/C cg16814680 chr8:91681699 NA -0.63 -9.74 -0.47 7.21e-20 Ejection fraction in Tripanosoma cruzi seropositivity; CRC cis rs6835098 0.961 rs2078475 chr4:174098226 A/C cg08422745 chr4:174089978 GALNT7 0.96 14.11 0.61 1.14e-35 Dementia and core Alzheimer's disease neuropathologic changes; CRC cis rs929596 0.564 rs2741029 chr2:234530160 A/C cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.42 -5.74 -0.3 2.15e-8 Total bilirubin levels in HIV-1 infection; CRC cis rs2204008 0.837 rs11180821 chr12:38242843 A/G cg13010199 chr12:38710504 ALG10B 0.45 5.95 0.31 6.72e-9 Bladder cancer; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg04623168 chr12:112546260 NAA25 0.49 6.98 0.36 1.62e-11 Intelligence (multi-trait analysis); CRC cis rs2797160 1.000 rs1612249 chr6:126014916 C/A cg05901451 chr6:126070800 HEY2 0.39 6.06 0.32 3.66e-9 Endometrial cancer; CRC cis rs2243480 1.000 rs34193460 chr7:65393110 A/G cg25985355 chr7:65971099 NA -0.49 -5.74 -0.3 2.11e-8 Diabetic kidney disease; CRC cis rs7586879 0.861 rs10164466 chr2:25114069 T/C cg22495460 chr2:25135724 ADCY3 -0.88 -15.06 -0.64 2.38e-39 Body mass index; CRC cis rs76878669 0.561 rs4930178 chr11:66129442 C/G cg18002602 chr11:66138449 SLC29A2 0.28 6.1 0.32 2.94e-9 Educational attainment (years of education); CRC cis rs2032447 0.639 rs198810 chr6:26128618 A/G cg03264133 chr6:25882463 NA 0.44 6.0 0.31 5.21e-9 Intelligence (multi-trait analysis); CRC cis rs35306767 0.761 rs12773961 chr10:1013215 C/G cg26597838 chr10:835615 NA 0.95 11.04 0.52 2.5300000000000002e-24 Eosinophil percentage of granulocytes; CRC cis rs34330 0.562 rs11055024 chr12:12858969 A/G cg04607235 chr12:12878440 APOLD1 -0.72 -7.34 -0.38 1.64e-12 Systemic lupus erythematosus; CRC cis rs7932354 0.502 rs10769233 chr11:47072655 T/C cg03339077 chr11:47165057 C11orf49 0.44 6.23 0.32 1.44e-9 Bone mineral density (hip);Bone mineral density; CRC cis rs113123495 0.609 rs2436499 chr19:5638054 C/T cg26242866 chr19:5711310 LONP1 -0.65 -5.61 -0.3 4.24e-8 Obsessive-compulsive symptoms; CRC cis rs6545883 0.929 rs2463100 chr2:61659199 C/G cg15711740 chr2:61764176 XPO1 -0.47 -6.15 -0.32 2.2e-9 Tuberculosis; CRC cis rs2933343 0.951 rs7648327 chr3:128570708 A/G cg11901034 chr3:128598214 ACAD9 -0.47 -5.75 -0.3 2.07e-8 IgG glycosylation; CRC cis rs10944 0.572 rs688180 chr5:78276747 C/T cg13121490 chr5:78280331 ARSB -0.44 -6.31 -0.33 9.23e-10 Blood and toenail selenium levels; CRC cis rs5750830 0.621 rs5750810 chr22:39792943 A/G cg25956985 chr22:39795188 MAP3K7IP1 -0.44 -6.43 -0.33 4.43e-10 Intelligence (multi-trait analysis); CRC cis rs7246657 0.943 rs7246993 chr19:37890154 C/T cg23950597 chr19:37808831 NA -0.54 -6.52 -0.34 2.58e-10 Coronary artery calcification; CRC cis rs6088813 0.767 rs4911179 chr20:33972899 A/C cg14752227 chr20:34000481 UQCC -0.36 -5.62 -0.3 3.99e-8 Height; CRC cis rs4862750 0.957 rs1030381 chr4:187903568 G/C cg07414643 chr4:187882934 NA 0.36 6.11 0.32 2.78e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs1799949 0.930 rs4445938 chr17:41337900 A/C cg05368731 chr17:41323189 NBR1 0.68 10.34 0.5 6.75e-22 Menopause (age at onset); CRC cis rs908922 0.627 rs1053588 chr1:152488063 C/T cg23254163 chr1:152506842 NA 0.44 8.66 0.43 2.23e-16 Hair morphology; CRC trans rs116095464 0.510 rs73016876 chr5:244475 T/C cg00938859 chr5:1591904 SDHAP3 0.72 7.71 0.39 1.55e-13 Breast cancer; CRC cis rs11674184 0.632 rs17529680 chr2:11727087 A/C cg07314298 chr2:11723111 GREB1 0.53 8.53 0.43 5.48e-16 Endometriosis; CRC cis rs1953600 0.870 rs1049550 chr10:81926702 G/A cg00277334 chr10:82204260 NA -0.37 -5.94 -0.31 7.31e-9 Sarcoidosis; CRC cis rs514406 0.607 rs6665324 chr1:53201610 G/A cg08859206 chr1:53392774 SCP2 0.41 6.49 0.34 3.21e-10 Monocyte count; CRC cis rs6772849 0.930 rs9868579 chr3:128351054 C/T cg08795948 chr3:128337044 NA -0.36 -6.15 -0.32 2.24e-9 Monocyte percentage of white cells;Monocyte count; CRC cis rs2153535 0.580 rs9406174 chr6:8516764 T/C cg21535247 chr6:8435926 SLC35B3 0.48 7.35 0.38 1.63e-12 Motion sickness; CRC cis rs6479527 0.806 rs914296 chr9:96765974 A/G cg14459158 chr9:96720562 NA 0.41 7.44 0.38 8.76e-13 Esophageal adenocarcinoma; CRC cis rs2976388 0.609 rs2572909 chr8:143806464 C/G cg22687807 chr8:143858763 LYNX1 0.5 8.91 0.44 3.5e-17 Urinary tract infection frequency; CRC cis rs6952808 0.964 rs6945719 chr7:1932688 G/A cg21782813 chr7:2030301 MAD1L1 0.49 8.38 0.42 1.59e-15 Bipolar disorder and schizophrenia; CRC trans rs7830371 0.545 rs2931311 chr8:62100551 T/A cg27108154 chr4:96761377 PDHA2 0.34 6.01 0.31 4.92e-9 Amyotrophic lateral sclerosis (sporadic); CRC cis rs4253772 0.591 rs8135363 chr22:46651713 T/C cg09491104 chr22:46646882 C22orf40 -0.48 -7.59 -0.39 3.33e-13 LDL cholesterol;Cholesterol, total; CRC trans rs7819412 0.875 rs6981523 chr8:11061792 C/T cg06636001 chr8:8085503 FLJ10661 -0.56 -8.54 -0.43 5.19e-16 Triglycerides; CRC cis rs713587 0.525 rs11687089 chr2:25082926 T/C cg22495460 chr2:25135724 ADCY3 -0.84 -16.07 -0.66 2.78e-43 Body mass index in non-asthmatics; CRC cis rs5758343 1 rs5758343 chr22:41816652 A/T cg06634786 chr22:41940651 POLR3H 0.7 7.85 0.4 6.01e-14 Allergic disease (asthma, hay fever or eczema); CRC cis rs10504229 0.679 rs72649109 chr8:58031274 A/T cg20607798 chr8:58055168 NA 0.5 5.86 0.31 1.15e-8 Developmental language disorder (linguistic errors); CRC cis rs9768139 0.733 rs13309363 chr7:158122179 C/A cg25566285 chr7:158114605 PTPRN2 0.46 7.15 0.37 5.79e-12 Calcium levels; CRC cis rs9443645 0.901 rs7742431 chr6:79679577 A/G cg05283184 chr6:79620031 NA -0.58 -9.08 -0.45 1.03e-17 Intelligence (multi-trait analysis); CRC cis rs8072100 0.967 rs62076549 chr17:45579555 T/G cg08085267 chr17:45401833 C17orf57 0.65 10.44 0.5 3.19e-22 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs7659604 0.539 rs3217771 chr4:122739483 G/A cg06713675 chr4:122721982 EXOSC9 -0.51 -8.31 -0.42 2.54e-15 Type 2 diabetes; CRC cis rs582297 1 rs582297 chr11:108165407 C/G cg14761454 chr11:108092087 ATM;NPAT 0.42 6.16 0.32 2.08e-9 Eosinophil counts;Eosinophil percentage of white cells;Sum eosinophil basophil counts; CRC cis rs7618915 0.571 rs6805539 chr3:52609710 T/A cg05573699 chr3:52720067 GNL3;PBRM1 -0.45 -6.52 -0.34 2.58e-10 Bipolar disorder; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg03294028 chr2:242255774 SEPT2;HDLBP 0.44 6.13 0.32 2.5e-9 Response to antipsychotic treatment; CRC trans rs8073060 0.544 rs225249 chr17:33942540 T/C cg19694781 chr19:47549865 TMEM160 -1.07 -15.45 -0.65 6.9e-41 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; CRC cis rs1005277 0.579 rs1780138 chr10:38501654 A/G cg25427524 chr10:38739819 LOC399744 -0.79 -14.49 -0.62 3.9e-37 Extrinsic epigenetic age acceleration; CRC cis rs860295 0.702 rs12040100 chr1:155611847 G/T cg02153340 chr1:155202674 NA -0.54 -6.65 -0.34 1.25e-10 Body mass index; CRC cis rs4423214 0.840 rs4435028 chr11:71183690 C/A cg13043300 chr11:71146211 DHCR7 -0.44 -5.98 -0.31 5.98e-9 Vitamin D levels; CRC cis rs9733 0.596 rs1415148 chr1:150705755 G/A cg15448220 chr1:150897856 SETDB1 0.45 6.4 0.33 5.48e-10 Tonsillectomy; CRC cis rs1577917 1.000 rs1999852 chr6:86705738 C/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.54 -6.95 -0.36 2.02e-11 Response to antipsychotic treatment; CRC cis rs55702914 0.712 rs6730590 chr2:198148084 A/G cg10820045 chr2:198174542 NA -0.39 -7.04 -0.36 1.15e-11 Major depression and alcohol dependence; CRC cis rs9914988 0.943 rs1035989 chr17:27143810 T/G cg07195577 chr17:27052828 TLCD1 0.41 5.92 0.31 7.89e-9 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs4731207 0.536 rs13307657 chr7:124600864 A/G cg23710748 chr7:124431027 NA -0.38 -6.08 -0.32 3.35e-9 Cutaneous malignant melanoma; CRC cis rs6547741 0.844 rs7586655 chr2:27915659 A/G cg27432699 chr2:27873401 GPN1 -0.86 -16.95 -0.68 8.89e-47 Oral cavity cancer; CRC cis rs4665809 1.000 rs2053367 chr2:26293413 T/C cg27170947 chr2:26402098 FAM59B -0.44 -5.88 -0.31 1.04e-8 Gut microbiome composition (summer); CRC cis rs13108904 0.901 rs7673398 chr4:1300077 G/A cg23123621 chr4:1343375 KIAA1530 0.35 6.42 0.33 4.68e-10 Obesity-related traits; CRC trans rs941823 0.951 rs4941977 chr13:41031535 C/T cg25432738 chr13:21009861 CRYL1 -0.43 -6.07 -0.32 3.57e-9 Ulcerative colitis;Inflammatory bowel disease; CRC cis rs2072499 0.966 rs6427307 chr1:156190083 A/G cg25208724 chr1:156163844 SLC25A44 1.07 24.77 0.81 3.61e-77 Testicular germ cell tumor; CRC cis rs921968 0.565 rs3770219 chr2:219619766 T/C cg02176678 chr2:219576539 TTLL4 -0.39 -6.31 -0.33 8.83e-10 Mean corpuscular hemoglobin concentration; CRC cis rs2832191 0.632 rs1984011 chr21:30337831 T/A cg08807101 chr21:30365312 RNF160 -0.73 -11.8 -0.55 5.07e-27 Dental caries; CRC cis rs6912958 0.781 rs2325064 chr6:88224467 G/A cg12350822 chr6:88032061 C6orf162;GJB7 -0.34 -6.41 -0.33 5.06e-10 Monocyte percentage of white cells; CRC cis rs752010 0.746 rs11210499 chr1:42089703 C/T cg06885757 chr1:42089581 HIVEP3 -0.5 -9.2 -0.45 4.31e-18 Lupus nephritis in systemic lupus erythematosus; CRC cis rs9914544 0.933 rs11871889 chr17:18771425 T/C cg26378065 chr17:18585709 ZNF286B 0.42 5.79 0.3 1.65e-8 Educational attainment (years of education); CRC cis rs743757 0.816 rs6792502 chr3:50531201 C/A cg08207895 chr3:50388901 TUSC4;CYB561D2 0.47 6.6 0.34 1.63e-10 Diastolic blood pressure; CRC cis rs7428 0.527 rs4832164 chr2:85546932 A/C cg24342717 chr2:85555507 TGOLN2 -0.78 -13.16 -0.59 4.73e-32 Ear protrusion; CRC cis rs6121246 0.567 rs6060247 chr20:30190720 C/G cg18721089 chr20:30220636 NA -0.51 -7.59 -0.39 3.31e-13 Mean corpuscular hemoglobin; CRC cis rs6502050 0.529 rs35585236 chr17:80116641 T/C cg22110888 chr17:80059540 CCDC57 0.41 6.5 0.34 2.95e-10 Life satisfaction; CRC cis rs2842992 0.915 rs2842958 chr6:160108425 A/G cg11366901 chr6:160182831 ACAT2 0.88 11.77 0.54 6.18e-27 Age-related macular degeneration (geographic atrophy); CRC cis rs589448 0.967 rs2617835 chr12:69753420 C/A cg22834771 chr12:69754056 YEATS4 -0.56 -8.73 -0.43 1.33e-16 Cerebrospinal fluid biomarker levels; CRC cis rs427941 0.632 rs201504 chr7:101759878 C/G cg06246474 chr7:101738831 CUX1 0.44 6.72 0.35 7.85e-11 Plasma omega-3 polyunsaturated fatty acid level (eicosapentaenoic acid); CRC cis rs11711311 0.955 rs9851812 chr3:113412362 G/A cg15478005 chr3:113465772 ATP6V1A;NAA50 0.46 6.33 0.33 7.92e-10 IgG glycosylation; CRC cis rs10089 1.000 rs10463838 chr5:127518305 C/T cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.7 9.48 0.46 5.39e-19 Ileal carcinoids; CRC cis rs9649213 0.593 rs6465678 chr7:98004057 T/C cg00277769 chr7:97922759 BAIAP2L1 -0.6 -10.37 -0.5 5.45e-22 Prostate cancer (SNP x SNP interaction); CRC cis rs644799 1.000 rs12291986 chr11:95523030 T/G cg25478527 chr11:95522999 CEP57;FAM76B 0.52 7.81 0.4 7.75e-14 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs2274273 0.615 rs67008693 chr14:55702693 T/C cg10130446 chr14:55658398 DLGAP5 -0.44 -5.87 -0.31 1.06e-8 Protein biomarker; CRC cis rs7727544 0.618 rs2631367 chr5:131705458 C/G cg14196790 chr5:131705035 SLC22A5 -0.4 -7.0 -0.36 1.42e-11 Blood metabolite levels; CRC cis rs904251 0.861 rs914349 chr6:37484715 A/C cg01843034 chr6:37503916 NA -0.47 -8.91 -0.44 3.55e-17 Cognitive performance; CRC cis rs10504229 0.639 rs55687236 chr8:58105856 C/T cg02290350 chr8:58132656 NA -0.58 -6.58 -0.34 1.82e-10 Developmental language disorder (linguistic errors); CRC cis rs13253111 0.687 rs7840565 chr8:28060783 C/T cg26534493 chr8:28060551 NA 0.39 6.67 0.35 1.05e-10 Childhood body mass index; CRC trans rs11098499 0.863 rs7669520 chr4:120515278 T/C cg25214090 chr10:38739885 LOC399744 0.66 10.3 0.49 9.74e-22 Corneal astigmatism; CRC cis rs12325245 0.536 rs12924708 chr16:58567643 G/A cg26666090 chr16:58549219 SETD6 0.9 6.11 0.32 2.86e-9 Schizophrenia; CRC cis rs7264396 0.635 rs6058382 chr20:34553948 C/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.61 -9.83 -0.48 3.75e-20 Total cholesterol levels; CRC trans rs11098499 0.954 rs71614438 chr4:120371252 G/A cg25214090 chr10:38739885 LOC399744 0.66 10.47 0.5 2.41e-22 Corneal astigmatism; CRC cis rs4727027 0.933 rs28767030 chr7:148825918 T/G cg23583168 chr7:148888333 NA -0.89 -15.24 -0.64 4.88e-40 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC cis rs6963495 0.818 rs73192141 chr7:105201129 T/G cg02135003 chr7:105160482 PUS7 -0.93 -12.2 -0.56 1.77e-28 Bipolar disorder (body mass index interaction); CRC trans rs6951245 1.000 rs74652290 chr7:1090109 G/A cg13565492 chr6:43139072 SRF -0.61 -6.28 -0.33 1.05e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs62458065 1.000 rs6462364 chr7:32464776 C/T cg20159608 chr7:32802032 NA -0.49 -6.2 -0.32 1.68e-9 Metabolite levels (HVA/MHPG ratio); CRC cis rs6860806 0.507 rs272882 chr5:131669161 G/T cg12564285 chr5:131593104 PDLIM4 0.44 7.44 0.38 8.72e-13 Breast cancer; CRC cis rs11112613 0.713 rs60865625 chr12:105940256 A/C cg03607813 chr12:105948248 NA 0.76 10.02 0.48 8.47e-21 Corrected insulin response;Corrected insulin response adjusted for insulin sensitivity index; CRC cis rs4243830 1.000 rs12401795 chr1:6594773 A/G cg05709478 chr1:6581295 PLEKHG5 0.61 6.08 0.32 3.42e-9 Body mass index; CRC cis rs4803468 1.000 rs284657 chr19:41929915 G/C cg09537434 chr19:41945824 ATP5SL -0.91 -17.78 -0.7 4.7e-50 Height; CRC cis rs7937682 0.883 rs631490 chr11:111452040 G/C cg11344533 chr11:111475393 SIK2 -0.31 -5.94 -0.31 7.24e-9 Primary sclerosing cholangitis; CRC cis rs4566357 0.615 rs12621808 chr2:227909522 A/C cg11843606 chr2:227700838 RHBDD1 -0.44 -6.85 -0.35 3.54e-11 Coronary artery disease; CRC cis rs6951245 1.000 rs76833820 chr7:1070278 A/T cg22907277 chr7:1156413 C7orf50 0.71 7.39 0.38 1.26e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs17767392 0.918 rs35822724 chr14:71776934 C/G cg13720639 chr14:72061746 SIPA1L1 -0.55 -6.95 -0.36 1.99e-11 Mitral valve prolapse; CRC trans rs6561151 0.957 rs2121034 chr13:44473866 G/T cg12856521 chr11:46389249 DGKZ 0.59 8.59 0.43 3.54e-16 Crohn's disease; CRC cis rs2404618 0.624 rs7012381 chr8:1475357 C/T cg02903104 chr8:1507517 DLGAP2 0.38 7.04 0.36 1.13e-11 Lung cancer; CRC cis rs7666738 0.687 rs6839454 chr4:99073914 T/C cg05340658 chr4:99064831 C4orf37 0.57 8.65 0.43 2.28e-16 Colonoscopy-negative controls vs population controls; CRC cis rs950169 0.580 rs35516100 chr15:85195430 C/T cg11189052 chr15:85197271 WDR73 0.65 9.56 0.47 2.8e-19 Schizophrenia; CRC cis rs1707322 0.964 rs7546237 chr1:46285610 A/C cg03146154 chr1:46216737 IPP 0.51 7.27 0.37 2.62e-12 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs2268241 0.938 rs9978223 chr21:34770358 G/A cg14850771 chr21:34775459 IFNGR2 0.79 10.54 0.5 1.45e-22 Obesity-related traits; CRC cis rs6500602 0.701 rs6500614 chr16:4573938 A/G cg14951292 chr16:4525986 HMOX2;NMRAL1 0.74 10.54 0.5 1.38e-22 Schizophrenia; CRC cis rs7586879 0.681 rs6756609 chr2:25121125 C/A cg04586622 chr2:25135609 ADCY3 -0.54 -10.08 -0.49 5.18e-21 Body mass index; CRC cis rs10504229 0.683 rs67492041 chr8:58140077 G/A cg24829409 chr8:58192753 C8orf71 -0.55 -8.03 -0.4 1.71e-14 Developmental language disorder (linguistic errors); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg16868751 chr10:96162146 TBC1D12 0.44 6.64 0.34 1.3100000000000001e-10 Response to antipsychotic treatment; CRC cis rs3741404 0.560 rs17699798 chr11:63898806 C/G cg06219103 chr11:63990595 FERMT3 0.47 7.65 0.39 2.17e-13 Platelet count; CRC cis rs4804416 0.779 rs62112763 chr19:7220013 C/G cg00428638 chr19:7224713 INSR 0.56 8.54 0.43 5.23e-16 Thyroid hormone levels;Hypothyroidism; CRC cis rs4268898 1.000 rs10195436 chr2:24436112 C/T cg06627628 chr2:24431161 ITSN2 0.49 7.31 0.37 2.02e-12 Asthma; CRC cis rs870825 0.655 rs28451943 chr4:185645572 C/T cg04058563 chr4:185651563 MLF1IP 0.72 9.22 0.45 3.65e-18 Blood protein levels; CRC cis rs1728785 0.901 rs1170420 chr16:68635877 G/C cg02972257 chr16:68554789 NA -0.55 -6.78 -0.35 5.68e-11 Ulcerative colitis; CRC cis rs2839186 0.967 rs17176131 chr21:47705237 T/C cg09417038 chr21:47716443 C21orf57 -0.42 -6.88 -0.35 2.98e-11 Testicular germ cell tumor; CRC cis rs7617480 0.648 rs7653408 chr3:48972351 A/C cg07636037 chr3:49044803 WDR6 0.84 10.83 0.51 1.37e-23 Subjective well-being (multi-trait analysis);Menarche (age at onset); CRC cis rs10540 1.000 rs12794284 chr11:477623 C/T cg15790184 chr11:494944 RNH1 0.6 6.17 0.32 1.96e-9 Body mass index; CRC cis rs896854 0.654 rs28716845 chr8:95974485 A/G cg13393036 chr8:95962371 TP53INP1 -0.54 -9.29 -0.46 2.16e-18 Type 2 diabetes; CRC cis rs8177253 0.574 rs6775042 chr3:133442245 G/T cg16262614 chr3:133464971 TF 0.34 6.2 0.32 1.69e-9 Iron status biomarkers; CRC cis rs9368481 0.594 rs7768643 chr6:26891919 C/T cg05192639 chr6:26864778 GUSBL1 0.34 6.1 0.32 3e-9 Autism spectrum disorder or schizophrenia; CRC cis rs2842992 0.673 rs6930904 chr6:160217433 T/A cg16489826 chr6:160211363 TCP1;MRPL18 0.5 6.28 0.33 1.08e-9 Age-related macular degeneration (geographic atrophy); CRC cis rs2153535 0.580 rs1414349 chr6:8472290 A/G cg07606381 chr6:8435919 SLC35B3 0.68 10.9 0.51 8.26e-24 Motion sickness; CRC cis rs73200209 0.744 rs61939693 chr12:116540478 G/A cg01776926 chr12:116560359 MED13L -0.63 -7.46 -0.38 7.76e-13 Total body bone mineral density; CRC cis rs3617 0.573 rs4687680 chr3:52907372 G/A cg11645453 chr3:52864694 ITIH4 0.33 6.12 0.32 2.6e-9 Red blood cell count;Autism spectrum disorder or schizophrenia; CRC cis rs7666738 0.716 rs6817529 chr4:99023213 T/C cg05340658 chr4:99064831 C4orf37 0.61 9.51 0.46 4.05e-19 Colonoscopy-negative controls vs population controls; CRC cis rs881375 1.000 rs10760121 chr9:123647915 G/T cg00246817 chr9:123691163 NA -0.47 -5.94 -0.31 7.33e-9 Rheumatoid arthritis; CRC cis rs4713118 0.513 rs9368547 chr6:28028067 A/G cg20615401 chr6:28092323 ZSCAN16 0.47 6.25 0.33 1.28e-9 Parkinson's disease; CRC cis rs7618501 0.635 rs34080578 chr3:50026029 A/C cg05623727 chr3:50126028 RBM5 0.45 7.52 0.38 5.18e-13 Intelligence (multi-trait analysis); CRC cis rs1552244 1.000 rs9834980 chr3:10065528 G/A cg08888203 chr3:10149979 C3orf24 0.69 9.69 0.47 1.04e-19 Alzheimer's disease; CRC trans rs2797160 1.000 rs6933302 chr6:126016951 T/C cg05039488 chr6:79577232 IRAK1BP1 0.51 7.59 0.39 3.37e-13 Endometrial cancer; CRC cis rs4665809 0.590 rs4665313 chr2:26415897 A/G cg25036284 chr2:26402008 FAM59B -0.62 -7.98 -0.4 2.39e-14 Gut microbiome composition (summer); CRC cis rs6831352 0.879 rs2851255 chr4:100042103 C/G cg12011299 chr4:100065546 ADH4 0.49 9.1 0.45 8.57e-18 Alcohol dependence; CRC trans rs60843830 1.000 rs79716074 chr2:277003 A/G cg11347411 chr7:150020925 ACTR3C;LRRC61 0.59 9.14 0.45 6.4e-18 Spherical equivalent (joint analysis main effects and education interaction); CRC cis rs933688 1.000 rs2839728 chr5:90727412 G/A cg02339078 chr5:90679543 LOC100129716;ARRDC3 0.88 14.94 0.64 7.12e-39 Smoking behavior; CRC cis rs7692995 1.000 rs10516315 chr4:18016877 A/G cg08925142 chr4:18023851 LCORL -0.52 -5.87 -0.31 1.09e-8 Height; CRC cis rs1030877 0.515 rs1020064 chr2:105897740 T/G cg02079111 chr2:105885981 TGFBRAP1 0.51 7.14 0.37 5.89e-12 Obesity-related traits; CRC cis rs9640161 0.789 rs34311995 chr7:150059255 T/C cg13722127 chr7:150037890 RARRES2 0.39 5.69 0.3 2.86e-8 Blood protein levels;Circulating chemerin levels; CRC cis rs10751667 0.621 rs10794351 chr11:946228 C/T cg06064525 chr11:970664 AP2A2 -0.31 -6.37 -0.33 6.36e-10 Alzheimer's disease (late onset); CRC cis rs832540 0.593 rs96844 chr5:56196604 G/A cg18230493 chr5:56204884 C5orf35 -0.41 -5.93 -0.31 7.56e-9 Coronary artery disease; CRC cis rs9534288 0.797 rs7989351 chr13:46534080 C/A cg15192986 chr13:46630673 CPB2 -0.68 -9.99 -0.48 1.09e-20 Blood protein levels; CRC cis rs12618769 0.652 rs72823801 chr2:99235055 A/G cg18455616 chr2:99124870 INPP4A 0.33 5.64 0.3 3.64e-8 Bipolar disorder; CRC cis rs6964587 0.967 rs13233496 chr7:91813035 T/C cg17063962 chr7:91808500 NA 0.81 13.0 0.58 1.74e-31 Breast cancer; CRC cis rs12760731 0.720 rs10913540 chr1:178340060 T/C cg00404053 chr1:178313656 RASAL2 0.94 9.89 0.48 2.37e-20 Obesity-related traits; CRC cis rs478304 0.619 rs10791822 chr11:65428706 T/C cg27068330 chr11:65405492 SIPA1 -0.8 -12.27 -0.56 9.65e-29 Acne (severe); CRC cis rs113835537 0.935 rs57043177 chr11:66423147 A/G cg22134325 chr11:66188745 NPAS4 0.41 6.71 0.35 8.55e-11 Airway imaging phenotypes; CRC trans rs875971 0.660 rs2191268 chr7:66110224 C/T cg13811448 chr19:12777509 MORG1;MAN2B1 -0.39 -5.99 -0.31 5.42e-9 Aortic root size; CRC cis rs2274273 0.875 rs2075602 chr14:55609774 A/G cg23234261 chr14:55582407 NA -0.29 -5.74 -0.3 2.13e-8 Protein biomarker; CRC cis rs539096 0.602 rs2970610 chr1:44097530 T/C cg12908607 chr1:44402522 ARTN -0.37 -6.7 -0.35 8.88e-11 Intelligence (multi-trait analysis); CRC cis rs7809950 0.906 rs2253269 chr7:107201114 C/T cg23024343 chr7:107201750 COG5 -0.6 -8.39 -0.42 1.44e-15 Coronary artery disease; CRC trans rs7395662 0.517 rs10838960 chr11:48584741 A/G cg03929089 chr4:120376271 NA -0.47 -6.61 -0.34 1.56e-10 HDL cholesterol; CRC trans rs10982213 0.830 rs2274163 chr9:117188714 C/T cg16128701 chr8:82193449 FABP5 0.38 5.96 0.31 6.52e-9 Interleukin-6 levels; CRC cis rs7212590 0.618 rs7219051 chr17:58032710 G/A cg10252138 chr17:58120427 NA -0.58 -6.28 -0.33 1.1e-9 Granulocyte percentage of myeloid white cells;Monocyte count;Monocyte percentage of white cells; CRC cis rs2415984 0.579 rs28636061 chr14:46959848 T/C cg14871534 chr14:47121158 RPL10L -0.43 -6.17 -0.32 1.95e-9 Number of children ever born; CRC trans rs875971 0.545 rs4718348 chr7:65906576 A/G cg02869306 chr7:64672164 INTS4L1 -0.42 -6.05 -0.32 4.02e-9 Aortic root size; CRC cis rs10089 0.953 rs17164427 chr5:127361736 C/G cg25462716 chr5:127418816 SLC12A2;FLJ33630 -0.71 -10.12 -0.49 4.01e-21 Ileal carcinoids; CRC cis rs7707921 0.705 rs226194 chr5:81585026 G/T cg21483461 chr5:81570383 RPS23 0.36 5.63 0.3 3.92e-8 Breast cancer; CRC cis rs9389248 0.690 rs2064101 chr6:135250530 G/A cg22676075 chr6:135203613 NA -0.67 -10.49 -0.5 2.18e-22 High light scatter reticulocyte percentage of red cells; CRC cis rs4588572 0.643 rs11744479 chr5:77729220 T/G cg11547950 chr5:77652471 NA -0.52 -7.05 -0.36 1.05e-11 Triglycerides; CRC trans rs4971059 0.654 rs10157801 chr1:155120012 A/G cg12026095 chr19:49468461 FTL -0.39 -6.31 -0.33 8.77e-10 Breast cancer; CRC cis rs9309711 0.623 rs4641971 chr2:3481857 A/C cg10845886 chr2:3471009 TTC15 0.46 7.35 0.38 1.63e-12 Neurofibrillary tangles; CRC cis rs2857891 0.773 rs2857897 chr11:6982082 A/C cg04053776 chr11:6947353 ZNF215 0.38 5.61 0.3 4.22e-8 Response to cytadine analogues (cytosine arabinoside); CRC cis rs72627509 0.904 rs12645070 chr4:57770106 G/A cg26694713 chr4:57773883 REST 0.49 5.65 0.3 3.43e-8 Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); CRC cis rs7666738 0.791 rs34437628 chr4:99029232 C/G cg17366294 chr4:99064904 C4orf37 0.44 7.48 0.38 6.96e-13 Colonoscopy-negative controls vs population controls; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg04575325 chr6:160210070 MRPL18;TCP1 0.48 6.81 0.35 4.78e-11 Response to antipsychotic treatment; CRC cis rs394563 0.601 rs431978 chr6:149793000 C/T cg11245181 chr6:149772854 ZC3H12D 0.47 7.69 0.39 1.68e-13 Dupuytren's disease; CRC cis rs2976388 0.524 rs7012804 chr8:143844650 A/G cg05569086 chr8:143859399 LYNX1 0.57 10.38 0.5 4.94e-22 Urinary tract infection frequency; CRC cis rs57221529 0.766 rs4245972 chr5:578572 A/G cg14541582 chr5:601475 NA -0.37 -7.13 -0.37 6.35e-12 Lung disease severity in cystic fibrosis; CRC cis rs172166 0.561 rs149971 chr6:27982152 G/A cg23161317 chr6:28129485 ZNF389 0.38 5.69 0.3 2.8e-8 Cardiac Troponin-T levels; CRC cis rs6495122 0.501 rs12148488 chr15:75382542 G/T cg17294928 chr15:75287854 SCAMP5 -0.45 -6.78 -0.35 5.51e-11 Caffeine consumption;Diastolic blood pressure;Coffee consumption; CRC cis rs870825 0.860 rs60022249 chr4:185600772 T/C cg04058563 chr4:185651563 MLF1IP 0.55 5.89 0.31 9.39e-9 Blood protein levels; CRC cis rs6582630 0.555 rs7294313 chr12:38323603 G/A cg26384229 chr12:38710491 ALG10B -0.55 -7.97 -0.4 2.69e-14 Drug-induced liver injury (flucloxacillin); CRC cis rs995000 0.965 rs11208004 chr1:63145439 G/A cg19896129 chr1:63156450 NA 0.39 5.68 0.3 2.95e-8 Triglyceride levels; CRC cis rs10504229 1.000 rs66495524 chr8:58187365 C/T cg02290350 chr8:58132656 NA -0.42 -5.96 -0.31 6.62e-9 Developmental language disorder (linguistic errors); CRC cis rs9549328 0.700 rs4907570 chr13:113617651 T/C cg20742385 chr13:113633654 MCF2L 0.56 9.53 0.46 3.7e-19 Systolic blood pressure; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg13452718 chr1:23670887 HNRNPR 0.48 6.17 0.32 2e-9 Thyroid stimulating hormone; CRC cis rs2235649 0.663 rs113908028 chr16:1848915 G/C cg00935504 chr16:1863053 HAGH 0.31 5.62 0.3 4.07e-8 Blood metabolite levels; CRC cis rs6582630 0.599 rs11181807 chr12:38403763 G/A cg26384229 chr12:38710491 ALG10B -0.52 -7.54 -0.38 4.69e-13 Drug-induced liver injury (flucloxacillin); CRC cis rs853679 1.000 rs1778508 chr6:28229881 C/T cg15786705 chr6:28176104 NA -0.55 -5.93 -0.31 7.64e-9 Depression; CRC cis rs4713118 0.955 rs9368528 chr6:27683798 G/A cg15786705 chr6:28176104 NA 0.48 6.42 0.33 4.89e-10 Parkinson's disease; CRC cis rs4319547 0.661 rs10846830 chr12:122897220 C/G cg23029597 chr12:123009494 RSRC2 -0.56 -6.95 -0.36 1.97e-11 Body mass index; CRC cis rs2463822 1.000 rs2513052 chr11:62108248 C/G cg06239285 chr11:62104954 ASRGL1 0.97 11.41 0.53 1.27e-25 Chronic obstructive pulmonary disease-related biomarkers; CRC trans rs7395662 0.782 rs4882064 chr11:48455757 C/T cg21153622 chr11:89784906 NA 0.48 7.56 0.38 3.92e-13 HDL cholesterol; CRC trans rs1728785 0.901 rs1170420 chr16:68635877 G/C cg04657470 chr2:198365150 HSPE1;HSPD1 0.6 7.25 0.37 3.08e-12 Ulcerative colitis; CRC cis rs17711722 0.701 rs4467826 chr7:65368708 A/G cg00343986 chr7:65444356 GUSB 0.55 8.47 0.42 8.58e-16 Calcium levels; CRC cis rs2243480 1.000 rs34193460 chr7:65393110 A/G cg18252515 chr7:66147081 NA -1.1 -12.55 -0.57 9.03e-30 Diabetic kidney disease; CRC cis rs4253772 0.637 rs11703173 chr22:46660367 G/A cg24881330 chr22:46731750 TRMU 0.56 5.77 0.3 1.85e-8 LDL cholesterol;Cholesterol, total; CRC trans rs1656966 1.000 rs1656966 chr3:186466252 C/T cg19442730 chr13:73634476 KLF5 0.41 6.24 0.33 1.33e-9 Myopia (pathological); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg20964256 chr4:146540759 MMAA 0.44 6.49 0.34 3.08e-10 Intelligence (multi-trait analysis); CRC cis rs4689592 0.503 rs56099074 chr4:7071259 A/G cg19539972 chr4:7069911 GRPEL1 -0.84 -9.73 -0.47 7.59e-20 Monocyte percentage of white cells; CRC cis rs2549003 0.674 rs960757 chr5:131826310 G/A cg21138405 chr5:131827807 IRF1 0.59 11.6 0.54 2.65e-26 Asthma (sex interaction); CRC cis rs4660306 1.000 rs2356561 chr1:45980862 T/G cg03123370 chr1:45965343 CCDC163P;MMACHC -0.54 -7.95 -0.4 2.96e-14 Homocysteine levels; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg14942134 chr8:94929220 PDP1 0.39 6.47 0.34 3.59e-10 Liver disease severity in Alagille syndrome; CRC cis rs7726839 0.540 rs72707016 chr5:665148 A/G cg14541582 chr5:601475 NA -0.34 -6.46 -0.34 3.71e-10 Obesity-related traits; CRC cis rs7584330 0.554 rs74001384 chr2:238424530 T/C cg14458575 chr2:238380390 NA 0.43 6.22 0.32 1.51e-9 Prostate cancer; CRC cis rs10876993 0.789 rs1689600 chr12:58049645 A/T cg18357645 chr12:58087776 OS9 0.58 7.9 0.4 4.29e-14 Celiac disease or Rheumatoid arthritis; CRC cis rs10189230 0.546 rs6436266 chr2:222357235 T/C cg14652038 chr2:222343519 EPHA4 0.39 6.06 0.32 3.76e-9 Urate levels in lean individuals; CRC cis rs896854 0.654 rs13248607 chr8:95986637 T/G cg16049864 chr8:95962084 TP53INP1 -0.65 -11.73 -0.54 9.04e-27 Type 2 diabetes; CRC cis rs9470366 0.883 rs9462210 chr6:36628953 G/A cg08179530 chr6:36648295 CDKN1A 0.51 6.11 0.32 2.85e-9 QRS duration; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg22233523 chr18:44497604 PIAS2 0.41 6.73 0.35 7.67e-11 Liver disease severity in Alagille syndrome; CRC cis rs62103177 0.564 rs2115996 chr18:77701007 C/G cg12964065 chr18:77638022 KCNG2 0.61 5.91 0.31 8.51e-9 Opioid sensitivity; CRC cis rs6502050 0.799 rs4789674 chr17:80123200 G/A cg25804541 chr17:80189381 SLC16A3 -0.3 -5.83 -0.31 1.3e-8 Life satisfaction; CRC cis rs17401966 0.838 rs34565762 chr1:10300119 T/C cg19773385 chr1:10388646 KIF1B -0.66 -10.78 -0.51 2.04e-23 Hepatocellular carcinoma; CRC cis rs1950626 0.833 rs2400963 chr14:101395706 A/G cg02351406 chr14:101447389 SNORD114-20;SNORD114-21 0.97 16.59 0.67 2.38e-45 Pelvic organ prolapse (moderate/severe); CRC cis rs7666738 0.830 rs6854994 chr4:98977624 C/G cg05340658 chr4:99064831 C4orf37 0.6 9.35 0.46 1.41e-18 Colonoscopy-negative controls vs population controls; CRC cis rs4722166 0.630 rs7808457 chr7:22798265 A/T cg05472934 chr7:22766657 IL6 -0.8 -13.26 -0.59 1.97e-32 Lung cancer; CRC cis rs728616 0.764 rs117833443 chr10:81738136 A/C cg11900509 chr10:81946545 ANXA11 -0.68 -6.82 -0.35 4.39e-11 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs2404602 0.716 rs12907805 chr15:76690606 C/T cg23625390 chr15:77176239 SCAPER 0.52 7.63 0.39 2.49e-13 Blood metabolite levels; CRC cis rs4665809 0.941 rs7602922 chr2:26265782 C/T cg25036284 chr2:26402008 FAM59B -0.47 -5.86 -0.31 1.13e-8 Gut microbiome composition (summer); CRC trans rs7821565 0.857 rs67281089 chr8:52173015 C/T cg09187163 chr7:72721838 NSUN5 -0.42 -6.05 -0.32 4.04e-9 Tuberculosis; CRC cis rs7312933 0.558 rs11181501 chr12:42822671 G/A cg19980929 chr12:42632907 YAF2 0.41 6.27 0.33 1.12e-9 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CRC cis rs780096 0.526 rs1647267 chr2:27651054 A/T cg21248554 chr2:27665150 KRTCAP3 -0.33 -7.72 -0.39 1.45e-13 Total body bone mineral density; CRC cis rs7523050 0.643 rs35885176 chr1:109401868 G/A cg08274380 chr1:109419600 GPSM2 0.85 6.65 0.34 1.24e-10 Fat distribution (HIV); CRC cis rs4319547 0.760 rs61954973 chr12:123074168 T/C cg23029597 chr12:123009494 RSRC2 -0.62 -7.77 -0.39 9.78e-14 Body mass index; CRC cis rs7394190 0.748 rs3781216 chr10:75522404 G/A cg07699608 chr10:75541558 CHCHD1 0.6 6.26 0.33 1.18e-9 Incident atrial fibrillation; CRC cis rs7762018 0.660 rs41265385 chr6:170068086 C/T cg19338460 chr6:170058176 WDR27 -0.88 -8.89 -0.44 4.03e-17 Thiazide-induced adverse metabolic effects in hypertensive patients; CRC trans rs10504229 1.000 rs17805656 chr8:58180318 T/C cg04077850 chr5:125800366 GRAMD3 0.37 6.27 0.33 1.15e-9 Developmental language disorder (linguistic errors); CRC cis rs769267 0.965 rs2023882 chr19:19405405 T/C cg02546618 chr19:19431379 KIAA0892;SF4 0.45 6.16 0.32 2.15e-9 Tonsillectomy; CRC cis rs2290159 0.800 rs73812836 chr3:12655149 T/G cg23032965 chr3:12705835 RAF1 0.47 6.31 0.33 8.78e-10 Cholesterol, total; CRC cis rs936229 0.749 rs7497201 chr15:75190690 A/G cg10253484 chr15:75165896 SCAMP2 -0.47 -6.95 -0.36 1.91e-11 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); CRC trans rs2727020 0.688 rs11040338 chr11:49360601 A/G cg03929089 chr4:120376271 NA 0.82 14.42 0.62 6.93e-37 Coronary artery disease; CRC cis rs4805272 0.626 rs6509072 chr19:29331703 C/G cg14983838 chr19:29218262 NA 0.4 5.68 0.3 2.96e-8 Plasma omega-3 polyunsaturated fatty acid levels (docosahexaenoic acid); CRC trans rs2303319 0.504 rs1023835 chr2:162593973 A/G cg22902534 chr3:183892754 AP2M1 -0.7 -6.1 -0.32 2.96e-9 Cognitive function; CRC trans rs6956675 0.915 rs10232119 chr7:62638227 C/T cg01314568 chr7:57830625 NA -0.69 -9.27 -0.46 2.44e-18 Obesity-related traits; CRC cis rs1707322 0.963 rs11211229 chr1:46400517 A/C cg03146154 chr1:46216737 IPP 0.5 7.07 0.36 9.58e-12 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs9322193 0.923 rs11155683 chr6:150100477 T/C cg07701084 chr6:150067640 NUP43 0.47 6.61 0.34 1.51e-10 Lung cancer; CRC cis rs709400 0.894 rs61996721 chr14:104061352 G/A cg12935359 chr14:103987150 CKB -0.38 -5.95 -0.31 7e-9 Body mass index; CRC cis rs6500602 0.564 rs3747584 chr16:4516092 A/G cg08645402 chr16:4508243 NA 0.6 8.98 0.44 2.12e-17 Schizophrenia; CRC cis rs892961 0.932 rs7207891 chr17:75413922 G/C cg05865280 chr17:75406074 SEPT9 0.6 13.48 0.6 2.9e-33 Airflow obstruction; CRC trans rs2243480 1.000 rs1553174 chr7:65731194 T/C cg10756647 chr7:56101905 PSPH -0.77 -7.87 -0.4 5.06e-14 Diabetic kidney disease; CRC cis rs1572438 1.000 rs873559 chr6:875336 G/A cg21062780 chr6:887772 NA 0.37 5.88 0.31 1.02e-8 Aging; CRC cis rs736408 0.522 rs11130310 chr3:52674667 C/T cg11645453 chr3:52864694 ITIH4 0.37 6.56 0.34 2.08e-10 Bipolar disorder; CRC cis rs7301016 0.846 rs11174575 chr12:63026392 G/A cg11441379 chr12:63026424 NA 0.54 5.65 0.3 3.47e-8 IgG glycosylation; CRC cis rs4665809 1.000 rs6739061 chr2:26256147 C/T cg04944784 chr2:26401820 FAM59B -0.58 -7.52 -0.38 5.39e-13 Gut microbiome composition (summer); CRC cis rs8008758 0.517 rs1620117 chr14:101696931 C/A cg26224664 chr14:101693935 NA -0.5 -8.92 -0.44 3.32e-17 Body mass index (alcohol intake interaction); CRC cis rs12208915 0.559 rs4706738 chr6:79514153 A/G cg09184832 chr6:79620586 NA 0.38 5.86 0.31 1.11e-8 Left atrial antero-posterior diameter; CRC cis rs4785763 0.570 rs4785759 chr16:90050880 G/T cg12064134 chr16:90016061 DEF8 -0.51 -8.24 -0.41 4.17e-15 Melanoma; CRC cis rs9894429 0.816 rs9747093 chr17:79584280 G/A cg21984481 chr17:79567631 NPLOC4 -0.52 -9.57 -0.47 2.61e-19 Eye color traits; CRC cis rs6988636 1.000 rs4282551 chr8:124185916 G/A cg27053337 chr8:124217698 FAM83A 0.45 6.84 0.35 3.77e-11 Urinary uromodulin levels; CRC cis rs4972806 0.814 rs6710370 chr2:177045969 T/C cg10305451 chr2:177043427 NA 0.72 11.49 0.54 6.4e-26 IgG glycosylation; CRC cis rs9488822 0.676 rs11757115 chr6:116362619 C/T cg26893134 chr6:116381904 FRK 0.28 7.99 0.4 2.28e-14 Cholesterol, total;LDL cholesterol; CRC cis rs10504229 1.000 rs17805326 chr8:58169533 A/C cg05313129 chr8:58192883 C8orf71 -0.49 -7.41 -0.38 1.09e-12 Developmental language disorder (linguistic errors); CRC cis rs1799949 1.000 rs35330014 chr17:41212547 C/T cg01879757 chr17:41196368 BRCA1 -0.43 -6.54 -0.34 2.35e-10 Menopause (age at onset); CRC cis rs8037137 1.000 rs1105291 chr15:91502383 C/T cg23684204 chr15:91497937 RCCD1 0.62 6.7 0.35 9.32e-11 Platelet count;Serous invasive ovarian cancer;High-grade serous ovarian cancer;Invasive epithelial ovarian cancer; CRC cis rs3858526 0.917 rs9284148 chr11:5973185 G/C cg26762873 chr11:5879799 OR52E8 -0.43 -5.98 -0.31 5.9e-9 DNA methylation (variation); CRC cis rs9467773 0.967 rs9461267 chr6:26525455 T/G cg09904177 chr6:26538194 HMGN4 0.86 14.68 0.63 7.22e-38 Intelligence (multi-trait analysis); CRC cis rs6424115 0.708 rs2076343 chr1:24129126 A/G cg15997130 chr1:24165203 NA -0.67 -8.54 -0.43 4.97e-16 Immature fraction of reticulocytes; CRC cis rs1862618 0.853 rs2432195 chr5:56120413 C/T cg12311346 chr5:56204834 C5orf35 -0.75 -9.89 -0.48 2.27e-20 Initial pursuit acceleration; CRC cis rs11690935 1.000 rs6721680 chr2:172543913 G/T cg13550731 chr2:172543902 DYNC1I2 1.07 19.28 0.73 6.04e-56 Schizophrenia; CRC cis rs3806933 0.522 rs12522383 chr5:110455266 C/T cg04022379 chr5:110408740 TSLP 0.6 8.84 0.44 5.84e-17 Eosinophilic esophagitis; CRC cis rs34034915 1 rs34034915 chr6:27720703 T/TG cg25164649 chr6:28176230 NA 0.54 7.8 0.4 8.18e-14 Hepatitis A; CRC cis rs6540559 0.546 rs59435160 chr1:210030730 C/A cg23283495 chr1:209979779 IRF6 0.42 5.89 0.31 9.56e-9 Cleft lip with or without cleft palate; CRC cis rs11677416 1.000 rs2856837 chr2:113541925 G/A cg27083787 chr2:113543245 IL1A 0.47 6.57 0.34 1.92e-10 Response to antipsychotic treatment in schizophrenia (working memory); CRC trans rs7705042 0.865 rs4391200 chr5:141509537 A/G cg03701575 chr16:83960119 NA 0.34 5.97 0.31 6.14e-9 Asthma; CRC cis rs4332037 0.851 rs1403175 chr7:1964357 A/T cg25834613 chr7:1915315 MAD1L1 0.44 6.52 0.34 2.61e-10 Bipolar disorder; CRC cis rs2576037 0.583 rs892586 chr18:44560429 C/A cg19077165 chr18:44547161 KATNAL2 0.65 10.65 0.51 6.04e-23 Personality dimensions; CRC cis rs9916302 0.706 rs28482878 chr17:37497100 A/G cg07936489 chr17:37558343 FBXL20 0.91 11.68 0.54 1.31e-26 Glomerular filtration rate (creatinine); CRC cis rs7833986 0.501 rs2667999 chr8:56950474 T/C cg23139584 chr8:56987506 RPS20;SNORD54 0.91 12.65 0.57 3.65e-30 Height; CRC cis rs9527 0.569 rs10786730 chr10:104724200 G/A cg15744005 chr10:104629667 AS3MT -0.31 -6.16 -0.32 2.07e-9 Arsenic metabolism; CRC cis rs524281 0.861 rs471484 chr11:65955144 A/G cg14036092 chr11:66035641 RAB1B -0.48 -6.01 -0.31 4.79e-9 Electroencephalogram traits; CRC cis rs6570726 0.935 rs379164 chr6:145829093 A/T cg23711669 chr6:146136114 FBXO30 0.68 12.16 0.56 2.33e-28 Lobe attachment (rater-scored or self-reported); CRC trans rs1607741 1.000 rs1402155 chr4:72705908 C/T cg06437464 chr6:127441704 RSPO3 -0.28 -6.07 -0.32 3.57e-9 Vitamin D levels; CRC trans rs916888 0.821 rs199507 chr17:44858855 A/G cg22968622 chr17:43663579 NA -1.2 -15.72 -0.65 6.5e-42 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs999943 0.846 rs1570760 chr6:33622933 C/T cg14003231 chr6:33640908 ITPR3 0.94 16.62 0.68 1.77e-45 Obesity (extreme); CRC cis rs1707322 0.963 rs11211238 chr1:46449415 G/A cg03146154 chr1:46216737 IPP 0.51 7.06 0.36 1.01e-11 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs9291683 0.618 rs13137343 chr4:10043028 C/A cg11266682 chr4:10021025 SLC2A9 0.53 11.09 0.52 1.76e-24 Bone mineral density; CRC cis rs6860806 0.507 rs2631364 chr5:131706914 C/G cg11843238 chr5:131593191 PDLIM4 -0.45 -7.57 -0.38 3.9e-13 Breast cancer; CRC cis rs950169 1.000 rs950169 chr15:84706461 C/T cg17507749 chr15:85114479 UBE2QP1 0.78 12.04 0.55 6.36e-28 Schizophrenia; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg18325920 chr2:27255615 TMEM214 0.44 6.27 0.33 1.14e-9 Response to antipsychotic treatment; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg10607599 chr11:120382422 NA 0.32 6.49 0.34 3.24e-10 Liver disease severity in Alagille syndrome; CRC cis rs10256972 0.552 rs2949195 chr7:1202705 G/A cg18402987 chr7:1209562 NA 0.57 8.6 0.43 3.2e-16 Longevity;Endometriosis; CRC trans rs11098499 0.863 rs13134665 chr4:120426430 T/C cg25214090 chr10:38739885 LOC399744 0.63 9.89 0.48 2.39e-20 Corneal astigmatism; CRC cis rs10504229 0.683 rs61306359 chr8:58134646 G/A cg04204079 chr8:58130323 NA -0.45 -5.78 -0.3 1.71e-8 Developmental language disorder (linguistic errors); CRC cis rs4953076 0.573 rs2054005 chr2:44401843 C/T cg04920474 chr2:44395004 PPM1B 0.57 7.63 0.39 2.57e-13 Height; CRC cis rs7580658 0.929 rs2276583 chr2:128014684 G/A cg09760422 chr2:128146352 NA -0.37 -7.25 -0.37 2.97e-12 Protein C levels; CRC cis rs9733 0.596 rs34140753 chr1:150642583 T/C cg17724175 chr1:150552817 MCL1 0.58 9.4 0.46 9.25e-19 Tonsillectomy; CRC cis rs1707322 1.000 rs6695421 chr1:46380207 T/C cg03146154 chr1:46216737 IPP 0.51 7.16 0.37 5.32e-12 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs853679 0.517 rs4713145 chr6:28106827 T/C cg12172441 chr6:28176163 NA 0.62 7.4 0.38 1.17e-12 Depression; CRC cis rs35150201 0.529 rs7806221 chr7:135318779 T/C cg23117316 chr7:135346802 PL-5283 -0.38 -6.61 -0.34 1.57e-10 Plateletcrit;Mean corpuscular hemoglobin;Mean platelet volume; CRC cis rs7945705 0.774 rs6486060 chr11:9024630 A/G cg21881798 chr11:8931708 C11orf17;ST5 0.61 9.89 0.48 2.27e-20 Hemoglobin concentration; CRC cis rs1707322 0.721 rs12069121 chr1:46231984 G/A cg03146154 chr1:46216737 IPP 0.66 9.52 0.46 3.97e-19 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs7208859 0.673 rs55658077 chr17:29156519 A/G cg13385521 chr17:29058706 SUZ12P 0.65 7.4 0.38 1.15e-12 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs11148252 0.846 rs9379 chr13:53050479 G/A cg00495681 chr13:53174319 NA 0.58 8.77 0.44 1.01e-16 Lewy body disease; CRC trans rs75246769 0.706 rs75576122 chr7:145695402 A/G cg14916917 chr5:81574294 RPS23 0.87 6.09 0.32 3.14e-9 Facial morphology (factor 10, width of nasal floor); CRC cis rs853679 1.000 rs9986596 chr6:28219661 G/A cg02683197 chr6:28174875 NA 0.61 5.74 0.3 2.19e-8 Depression; CRC cis rs728616 0.510 rs34782759 chr10:82195219 T/C cg05935833 chr10:81318306 SFTPA2 -0.55 -6.34 -0.33 7.72e-10 Chronic obstructive pulmonary disease-related biomarkers; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg07328115 chr20:25228580 PYGB 0.48 6.02 0.31 4.57e-9 Thyroid stimulating hormone; CRC cis rs6456156 0.774 rs6931530 chr6:167527200 A/C cg05540913 chr6:167530185 CCR6 -0.41 -7.45 -0.38 8.07e-13 Primary biliary cholangitis; CRC cis rs10486722 0.606 rs2190337 chr7:41796420 C/T cg22138096 chr7:41772439 LOC285954 0.44 5.67 0.3 3.12e-8 Pit-and-Fissure caries; CRC cis rs11098499 0.739 rs9996382 chr4:120151012 C/T cg24375607 chr4:120327624 NA 0.48 7.94 0.4 3.23e-14 Corneal astigmatism; CRC cis rs7493 0.755 rs62467350 chr7:94970114 T/C cg17330251 chr7:94953956 PON1 -0.52 -6.71 -0.35 8.33e-11 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs1865760 0.963 rs3846838 chr6:25911775 T/C cg16482183 chr6:26056742 HIST1H1C 0.54 7.88 0.4 4.95e-14 Height; CRC cis rs9747201 0.926 rs34153075 chr17:80135728 C/A cg09264619 chr17:80180166 NA 0.49 6.93 0.36 2.23e-11 Peripheral arterial disease (traffic-related air pollution interaction); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg15239263 chr16:31086047 ZNF668;ZNF646 0.46 6.47 0.34 3.64e-10 Response to antipsychotic treatment; CRC cis rs2153535 0.580 rs1577472 chr6:8486215 G/A cg07606381 chr6:8435919 SLC35B3 0.67 10.69 0.51 4.33e-23 Motion sickness; CRC trans rs2303319 0.504 rs56965753 chr2:162597251 A/G cg12500891 chr11:57225987 NA -0.65 -6.06 -0.32 3.77e-9 Cognitive function; CRC cis rs8031584 0.678 rs4779497 chr15:31151365 T/A cg08109568 chr15:31115862 NA -0.68 -10.62 -0.51 7.54e-23 Huntington's disease progression; CRC cis rs13191362 1.000 rs35754151 chr6:163074867 A/G cg14584255 chr6:163149320 PACRG;PARK2 0.44 6.36 0.33 6.71e-10 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs6740322 0.895 rs10210125 chr2:43556433 C/G cg06169590 chr2:43455088 ZFP36L2;LOC100129726 -0.62 -7.56 -0.38 3.93e-13 Coronary artery disease; CRC cis rs11785400 0.762 rs1137522 chr8:143739020 A/C cg24634471 chr8:143751801 JRK 0.47 6.41 0.33 5.17e-10 Schizophrenia; CRC cis rs6496667 0.865 rs7161929 chr15:90884009 G/A cg04176472 chr15:90893244 GABARAPL3 0.58 6.58 0.34 1.83e-10 Rheumatoid arthritis; CRC cis rs208520 0.690 rs12208977 chr6:66725257 G/A cg07460842 chr6:66804631 NA 1.06 14.71 0.63 5.2e-38 Exhaled nitric oxide output; CRC cis rs9515203 1.000 rs9515203 chr13:111049623 C/T cg15455643 chr13:111040242 COL4A2 0.44 6.18 0.32 1.92e-9 Coronary artery disease; CRC trans rs7395662 0.591 rs7482521 chr11:48609735 G/A cg21153622 chr11:89784906 NA -0.53 -8.8 -0.44 8.03e-17 HDL cholesterol; CRC cis rs910316 0.737 rs175049 chr14:75481368 C/T cg11812906 chr14:75593930 NEK9 -0.56 -8.56 -0.43 4.27e-16 Height; CRC cis rs6964587 0.869 rs10276682 chr7:91486070 G/A cg17063962 chr7:91808500 NA -0.77 -13.15 -0.59 4.78e-32 Breast cancer; CRC cis rs79349575 0.783 rs62075820 chr17:46983171 G/C cg22482690 chr17:47019901 SNF8 0.49 8.2 0.41 5.33e-15 Type 2 diabetes; CRC cis rs4713118 0.662 rs149901 chr6:27965503 C/T cg15845792 chr6:28175446 NA 0.8 11.85 0.55 3.12e-27 Parkinson's disease; CRC cis rs929354 0.713 rs7798816 chr7:156940574 A/G cg16102536 chr7:156981717 UBE3C 0.4 6.69 0.35 9.57e-11 Body mass index; CRC cis rs34375054 0.525 rs7133006 chr12:125606123 G/A cg06987292 chr12:125626746 AACS -0.37 -6.23 -0.32 1.46e-9 Post bronchodilator FEV1/FVC ratio; CRC cis rs10504229 0.861 rs116964504 chr8:58185354 A/C cg01721255 chr8:58191610 C8orf71 0.49 6.17 0.32 2e-9 Developmental language disorder (linguistic errors); CRC cis rs73195822 0.667 rs59789826 chr12:111235110 T/C cg12870014 chr12:110450643 ANKRD13A 0.56 5.66 0.3 3.22e-8 Itch intensity from mosquito bite; CRC cis rs10504229 0.679 rs1596142 chr8:58032406 G/A cg22535103 chr8:58192502 C8orf71 -0.44 -5.85 -0.31 1.21e-8 Developmental language disorder (linguistic errors); CRC cis rs9443645 0.901 rs2050662 chr6:79753073 G/C cg05283184 chr6:79620031 NA -0.62 -9.76 -0.47 6.15e-20 Intelligence (multi-trait analysis); CRC trans rs1814175 0.645 rs10128731 chr11:50023554 G/T cg11707556 chr5:10655725 ANKRD33B -0.51 -9.92 -0.48 1.84e-20 Height; CRC cis rs11758351 0.715 rs76130408 chr6:26208962 A/G cg10723962 chr6:26240782 HIST1H4F -0.39 -6.25 -0.33 1.25e-9 Gout;Renal underexcretion gout; CRC cis rs875971 0.861 rs801215 chr7:66011938 A/T cg18252515 chr7:66147081 NA 0.43 6.19 0.32 1.77e-9 Aortic root size; CRC cis rs8005677 0.828 rs3794452 chr14:23386682 T/G cg25600027 chr14:23388339 RBM23 -0.46 -6.92 -0.36 2.35e-11 Cognitive ability (multi-trait analysis); CRC cis rs11030122 0.702 rs995498 chr11:3967791 A/G cg18678763 chr11:4115507 RRM1 -0.51 -8.35 -0.42 1.95e-15 Mean platelet volume;Platelet distribution width; CRC cis rs9747201 0.962 rs11656153 chr17:80072950 G/A cg09264619 chr17:80180166 NA 0.51 7.2 0.37 4.03e-12 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs3008870 0.755 rs2755251 chr1:67496425 G/T cg08660285 chr1:67390436 MIER1;WDR78 0.51 7.18 0.37 4.81e-12 Lymphocyte percentage of white cells; CRC cis rs72615157 0.606 rs941288 chr7:99776808 G/A cg07160278 chr7:100027354 MEPCE;ZCWPW1 0.71 8.37 0.42 1.67e-15 Lung function (FEV1/FVC); CRC cis rs6543140 0.964 rs13390895 chr2:103075499 G/A cg09003973 chr2:102972529 NA 0.41 5.83 0.31 1.33e-8 Blood protein levels; CRC cis rs2839186 0.619 rs55689527 chr21:47622727 A/G cg11766577 chr21:47581405 C21orf56 -0.4 -6.41 -0.33 4.9e-10 Testicular germ cell tumor; CRC trans rs11098499 0.865 rs2389809 chr4:120377399 T/C cg25214090 chr10:38739885 LOC399744 0.66 10.56 0.5 1.18e-22 Corneal astigmatism; CRC cis rs7216064 1.000 rs12451511 chr17:65874861 T/G cg12091567 chr17:66097778 LOC651250 -0.67 -7.74 -0.39 1.24e-13 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CRC cis rs12474201 0.894 rs4952842 chr2:46925730 C/A cg06386533 chr2:46925753 SOCS5 0.84 13.84 0.61 1.2e-34 Height; CRC cis rs12618769 0.652 rs3754871 chr2:99224309 A/T cg18455616 chr2:99124870 INPP4A 0.34 5.72 0.3 2.41e-8 Bipolar disorder; CRC cis rs9443645 1.000 rs9443645 chr6:79822924 C/T cg05283184 chr6:79620031 NA -0.54 -8.49 -0.42 7.4e-16 Intelligence (multi-trait analysis); CRC cis rs117623576 0.941 rs7911845 chr10:32441827 T/C cg03047570 chr10:32398778 NA -0.66 -6.28 -0.33 1.04e-9 Anti-saccade response; CRC cis rs769267 0.930 rs2099334 chr19:19578450 A/G cg03709012 chr19:19516395 GATAD2A 0.72 11.24 0.53 4.97e-25 Tonsillectomy; CRC cis rs9381040 1.000 rs2093396 chr6:41155000 G/A cg04346459 chr6:41068666 NFYA;LOC221442 -0.41 -5.85 -0.31 1.2e-8 Alzheimer's disease (late onset); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg16057782 chr17:6347554 FAM64A 0.38 6.17 0.32 1.97e-9 Liver disease severity in Alagille syndrome; CRC cis rs40363 0.723 rs2379831 chr16:3538927 T/C cg05754148 chr16:3507555 NAT15 -0.66 -6.1 -0.32 2.94e-9 Tuberculosis; CRC cis rs66573146 0.831 rs56320732 chr4:6974319 G/A cg00086871 chr4:6988644 TBC1D14 1.02 8.46 0.42 9.13e-16 Granulocyte percentage of myeloid white cells; CRC cis rs1008375 0.898 rs2079892 chr4:17577163 G/A cg02297831 chr4:17616191 MED28 0.44 5.73 0.3 2.27e-8 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs12024301 0.557 rs12029676 chr1:183594057 G/A cg11505048 chr1:183622726 RGL1;APOBEC4 0.72 6.52 0.34 2.64e-10 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs1223397 0.651 rs2919685 chr6:13311668 T/C cg07912922 chr6:13274314 PHACTR1 0.38 5.96 0.31 6.61e-9 Blood pressure; CRC trans rs10983614 1.000 rs7867776 chr9:120072627 A/G cg05350293 chr16:89119002 NA 0.32 6.0 0.31 5.23e-9 Survival in pancreatic cancer; CRC cis rs7224737 1.000 rs12603327 chr17:40290552 T/C cg20291162 chr17:40259547 DHX58 -0.55 -8.01 -0.4 2.06e-14 Fibrinogen levels; CRC cis rs1552244 0.554 rs2272122 chr3:10047975 C/G cg18598329 chr3:10140678 FANCD2;C3orf24 -0.53 -7.35 -0.38 1.62e-12 Alzheimer's disease; CRC cis rs17270561 0.636 rs1165216 chr6:25797971 G/A cg16482183 chr6:26056742 HIST1H1C 0.6 8.12 0.41 9.28e-15 Iron status biomarkers; CRC cis rs6964587 1.000 rs6953515 chr7:91658620 C/T cg17063962 chr7:91808500 NA 0.76 12.46 0.57 1.81e-29 Breast cancer; CRC cis rs524281 0.861 rs580891 chr11:65954681 A/C cg16950941 chr11:66035639 RAB1B -0.58 -7.35 -0.38 1.56e-12 Electroencephalogram traits; CRC cis rs6748734 1.000 rs4675863 chr2:241830763 A/T cg16358738 chr2:241808595 AGXT -0.39 -5.82 -0.31 1.42e-8 Urinary metabolites; CRC cis rs294883 0.686 rs7767003 chr6:159728138 T/C cg14500486 chr6:159655392 FNDC1 -0.36 -6.19 -0.32 1.81e-9 Coronary artery disease; CRC cis rs911555 0.570 rs11625397 chr14:104027557 A/G cg12935359 chr14:103987150 CKB 0.48 7.87 0.4 5.33e-14 Intelligence (multi-trait analysis); CRC cis rs4713118 0.662 rs9380046 chr6:28030499 T/C cg15786705 chr6:28176104 NA 0.69 9.23 0.45 3.35e-18 Parkinson's disease; CRC cis rs1801251 1.000 rs35212961 chr2:233582762 C/T cg25237894 chr2:233734115 C2orf82 0.53 8.35 0.42 1.94e-15 Coronary artery disease; CRC cis rs7945705 0.934 rs1988709 chr11:8882890 A/T cg12365402 chr11:9010492 NRIP3 0.47 7.62 0.39 2.78e-13 Hemoglobin concentration; CRC cis rs67385638 0.962 rs72872549 chr11:5290053 C/T cg21506790 chr11:5277210 HBG2 0.36 5.86 0.31 1.15e-8 Hemoglobin levels; CRC cis rs4665809 1.000 rs7588802 chr2:26277789 A/G cg22920501 chr2:26401640 FAM59B -0.57 -7.88 -0.4 4.86e-14 Gut microbiome composition (summer); CRC cis rs9503598 0.714 rs7758776 chr6:3452245 C/T cg00476032 chr6:3446245 SLC22A23 0.39 6.53 0.34 2.44e-10 Cognitive ability (multi-trait analysis);Cognitive ability;Intelligence (multi-trait analysis); CRC cis rs10504229 1.000 rs61212428 chr8:58173963 G/A cg01721255 chr8:58191610 C8orf71 0.49 6.17 0.32 2e-9 Developmental language disorder (linguistic errors); CRC cis rs4665809 1.000 rs1371553 chr2:26262948 G/A cg27170947 chr2:26402098 FAM59B -0.44 -5.8 -0.3 1.54e-8 Gut microbiome composition (summer); CRC cis rs9467711 0.516 rs1165184 chr6:25836257 C/G cg08501292 chr6:25962987 TRIM38 0.58 6.52 0.34 2.58e-10 Autism spectrum disorder or schizophrenia; CRC cis rs802075 0.676 rs13204884 chr6:49791907 G/A cg20364632 chr6:49636226 NA 0.35 5.91 0.31 8.66e-9 Bone mineral density (hip) and age at menarche; CRC cis rs5758511 0.680 rs17002902 chr22:42625509 C/G cg00645731 chr22:42541494 CYP2D7P1 0.66 10.14 0.49 3.45e-21 Birth weight; CRC cis rs4665809 0.590 rs4665318 chr2:26424517 C/T cg22920501 chr2:26401640 FAM59B 0.84 11.83 0.55 3.8e-27 Gut microbiome composition (summer); CRC cis rs9322193 0.884 rs7769115 chr6:150169932 C/T cg05861140 chr6:150128134 PCMT1 -0.43 -6.9 -0.36 2.62e-11 Lung cancer; CRC cis rs11958404 1.000 rs9686690 chr5:157412103 C/T cg05962755 chr5:157440814 NA 0.78 10.75 0.51 2.66e-23 IgG glycosylation; CRC cis rs3741404 0.825 rs11603538 chr11:63986713 C/A cg06219103 chr11:63990595 FERMT3 -0.41 -6.21 -0.32 1.56e-9 Platelet count; CRC cis rs6502050 0.805 rs11651863 chr17:80084539 T/C cg02741985 chr17:80059408 CCDC57 -0.44 -7.19 -0.37 4.48e-12 Life satisfaction; CRC cis rs10751667 0.925 rs7115336 chr11:988101 C/G cg23136738 chr11:925521 AP2A2 -0.48 -7.63 -0.39 2.49e-13 Alzheimer's disease (late onset); CRC cis rs1799949 1.000 rs16940 chr17:41245237 A/G cg05368731 chr17:41323189 NBR1 0.65 9.44 0.46 6.99e-19 Menopause (age at onset); CRC trans rs1814175 0.791 rs10769625 chr11:49869887 G/A cg03929089 chr4:120376271 NA -0.97 -19.07 -0.72 3.93e-55 Height; CRC cis rs12477438 0.501 rs2516833 chr2:99777405 T/C cg14399236 chr2:99771627 LIPT1;TSGA10 0.73 12.17 0.56 2.24e-28 Chronic sinus infection; CRC cis rs6461049 0.608 rs3800923 chr7:2184673 A/G cg04267008 chr7:1944627 MAD1L1 -0.43 -6.08 -0.32 3.39e-9 Schizophrenia; CRC cis rs6088580 0.524 rs6088564 chr20:33249444 A/G cg08999081 chr20:33150536 PIGU -0.37 -5.61 -0.3 4.4e-8 Glomerular filtration rate (creatinine); CRC cis rs7607369 0.536 rs6436092 chr2:219669148 T/A cg02176678 chr2:219576539 TTLL4 -0.37 -5.9 -0.31 8.89e-9 Red blood cell count;Amyotrophic lateral sclerosis; CRC cis rs1129187 0.967 rs11752813 chr6:42928017 C/G cg26304593 chr6:42947056 PEX6 -0.42 -5.99 -0.31 5.62e-9 Alzheimer's disease in APOE e4+ carriers; CRC cis rs748404 0.588 rs2255410 chr15:43831097 G/A cg02155558 chr15:43621948 ADAL;LCMT2 0.51 7.52 0.38 5.15e-13 Lung cancer; CRC cis rs7824557 0.564 rs2043508 chr8:11227406 G/A cg20542592 chr8:11973495 FAM66D 0.32 5.72 0.3 2.44e-8 Retinal vascular caliber; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg03258011 chr17:54857409 NA 0.51 6.87 0.35 3.16e-11 Thyroid stimulating hormone; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg13902498 chr15:75249203 RPP25 0.41 6.11 0.32 2.83e-9 Liver disease severity in Alagille syndrome; CRC cis rs12681287 0.570 rs10956830 chr8:87430483 T/A cg27223183 chr8:87520930 FAM82B 0.52 7.41 0.38 1.09e-12 Caudate activity during reward; CRC cis rs2842992 0.747 rs1547093 chr6:160205991 C/A cg11366901 chr6:160182831 ACAT2 0.96 14.1 0.61 1.2e-35 Age-related macular degeneration (geographic atrophy); CRC cis rs9303401 0.659 rs17822735 chr17:56620167 C/T cg10487724 chr17:56770010 TEX14;RAD51C 0.79 9.6 0.47 2.05e-19 Cognitive test performance; CRC cis rs896854 0.967 rs10808671 chr8:95967372 A/G cg13393036 chr8:95962371 TP53INP1 -0.55 -9.29 -0.46 2.1e-18 Type 2 diabetes; CRC cis rs2559856 1.000 rs2559856 chr12:102089561 A/G cg12924262 chr12:102091054 CHPT1 0.54 7.98 0.4 2.41e-14 Blood protein levels; CRC cis rs6502050 0.835 rs3935403 chr17:80114145 C/T cg13198984 chr17:80129470 CCDC57 0.45 8.12 0.41 9.48e-15 Life satisfaction; CRC cis rs11650494 0.908 rs9907478 chr17:47395729 C/T cg08112188 chr17:47440006 ZNF652 1.19 11.1 0.52 1.64e-24 Prostate cancer; CRC cis rs4665809 0.590 rs10197494 chr2:26445550 A/G cg22920501 chr2:26401640 FAM59B -0.83 -11.96 -0.55 1.28e-27 Gut microbiome composition (summer); CRC cis rs56146971 0.763 rs11160005 chr14:91872587 G/C cg16433844 chr14:91963127 SMEK1 -0.55 -6.29 -0.33 9.97e-10 Alzheimer disease and age of onset; CRC cis rs644799 0.672 rs61902245 chr11:95517737 C/T cg25478527 chr11:95522999 CEP57;FAM76B 0.5 7.67 0.39 2.02e-13 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs10504229 0.683 rs58438731 chr8:58134790 C/T cg05313129 chr8:58192883 C8orf71 -0.43 -6.11 -0.32 2.74e-9 Developmental language disorder (linguistic errors); CRC cis rs7932354 0.528 rs4319472 chr11:47109514 G/C cg19486271 chr11:47235900 DDB2 0.45 6.49 0.34 3.13e-10 Bone mineral density (hip);Bone mineral density; CRC cis rs11190604 1.000 rs7099913 chr10:102314777 T/C cg07080220 chr10:102295463 HIF1AN 0.48 6.15 0.32 2.28e-9 Palmitoleic acid (16:1n-7) levels; CRC cis rs6570726 0.791 rs6570694 chr6:145911204 C/G cg05347473 chr6:146136440 FBXO30 0.38 5.71 0.3 2.52e-8 Lobe attachment (rater-scored or self-reported); CRC trans rs2727020 0.513 rs10839307 chr11:49609843 A/C cg21153622 chr11:89784906 NA -0.38 -6.17 -0.32 1.96e-9 Coronary artery disease; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg02386244 chr16:3030649 PKMYT1 0.47 6.67 0.35 1.08e-10 Anxiety disorder; CRC cis rs524023 1.000 rs524023 chr11:64358265 C/T cg14139581 chr11:64358342 SLC22A12 0.38 6.04 0.32 4.13e-9 Urate levels in obese individuals; CRC cis rs758970 0.523 rs887659 chr9:129184309 C/T cg15282417 chr9:129245246 FAM125B -0.34 -5.86 -0.31 1.1e-8 Obesity-related traits; CRC cis rs1728785 0.901 rs1631910 chr16:68603335 G/A cg02972257 chr16:68554789 NA -0.6 -7.52 -0.38 5.1e-13 Ulcerative colitis; CRC cis rs703842 1.000 rs11172342 chr12:58187758 G/T cg00677455 chr12:58241039 CTDSP2 0.64 8.66 0.43 2.14e-16 Multiple sclerosis; CRC cis rs13191362 0.935 rs67084568 chr6:162988548 C/A cg21926612 chr6:163149169 PACRG;PARK2 0.82 11.49 0.54 6.51e-26 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs2758596 1.000 rs2758617 chr1:156160693 A/G cg24450063 chr1:156163899 SLC25A44 0.75 6.9 0.36 2.75e-11 Paclitaxel disposition in epithelial ovarian cancer; CRC trans rs1814175 0.645 rs28634872 chr11:50042175 T/A cg11707556 chr5:10655725 ANKRD33B -0.5 -9.83 -0.48 3.72e-20 Height; CRC cis rs7429990 0.930 rs13072132 chr3:47866161 A/G cg11946769 chr3:48343235 NME6 0.56 6.43 0.33 4.52e-10 Educational attainment (years of education); CRC cis rs595982 0.527 rs73061656 chr19:49372355 G/A cg21252483 chr19:49399788 TULP2 -0.37 -5.9 -0.31 8.91e-9 Red cell distribution width; CRC cis rs9381040 0.610 rs6940356 chr6:41020360 C/T cg04346459 chr6:41068666 NFYA;LOC221442 -0.41 -6.2 -0.32 1.67e-9 Alzheimer's disease (late onset); CRC cis rs16852403 0.548 rs12410235 chr1:178184782 C/A cg00404053 chr1:178313656 RASAL2 0.5 6.58 0.34 1.86e-10 Childhood ear infection; CRC cis rs7264396 0.832 rs224361 chr20:34061578 T/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.42 -6.81 -0.35 4.53e-11 Total cholesterol levels; CRC cis rs8062405 1.000 rs4451951 chr16:28836205 T/C cg16576597 chr16:28551801 NUPR1 0.48 7.0 0.36 1.44e-11 Cognitive ability (multi-trait analysis);Cognitive ability; CRC trans rs7267979 0.866 rs2424698 chr20:25256106 C/T cg17903999 chr18:56338584 MALT1 -0.39 -6.13 -0.32 2.47e-9 Liver enzyme levels (alkaline phosphatase); CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg18954434 chr22:46692881 CN5H6.4;GTSE1 0.47 6.71 0.35 8.43e-11 Anxiety disorder; CRC cis rs10504229 0.639 rs56066782 chr8:58105857 A/G cg02290350 chr8:58132656 NA -0.59 -8.02 -0.4 1.88e-14 Developmental language disorder (linguistic errors); CRC cis rs28386778 0.863 rs2665834 chr17:61904724 T/C cg06873352 chr17:61820015 STRADA 0.77 14.59 0.63 1.54e-37 Prudent dietary pattern; CRC trans rs12517041 1.000 rs4701362 chr5:23300849 G/A ch.8.1293020R chr8:59333349 UBXN2B -0.54 -5.96 -0.31 6.46e-9 Calcium levels; CRC cis rs2658782 1.000 rs2605583 chr11:93164957 T/A cg15737290 chr11:93063684 CCDC67 0.51 7.26 0.37 2.85e-12 Pulmonary function decline; CRC cis rs875971 1.000 rs778722 chr7:65844828 T/C cg18912574 chr7:65842487 NCRNA00174 0.36 6.18 0.32 1.88e-9 Aortic root size; CRC cis rs9527 0.545 rs10218853 chr10:104796787 A/C cg15744005 chr10:104629667 AS3MT -0.31 -6.3 -0.33 9.32e-10 Arsenic metabolism; CRC cis rs644799 1.000 rs494829 chr11:95571750 C/A cg03916912 chr11:95522834 CEP57;FAM76B 0.96 18.48 0.71 8.6e-53 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs6582630 0.524 rs10785494 chr12:38532431 C/G cg26384229 chr12:38710491 ALG10B -0.52 -7.61 -0.39 2.96e-13 Drug-induced liver injury (flucloxacillin); CRC cis rs4819052 0.851 rs2838843 chr21:46669284 T/C cg02159808 chr21:46707872 POFUT2;LOC642852 0.47 6.16 0.32 2.13e-9 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs394563 0.591 rs11964335 chr6:149658101 A/T cg17885791 chr6:149771845 ZC3H12D 0.31 5.66 0.3 3.32e-8 Dupuytren's disease; CRC cis rs9311474 0.539 rs12489828 chr3:52567014 G/T cg08365687 chr3:52569147 NT5DC2;LOC440957 0.34 5.65 0.3 3.46e-8 Electroencephalogram traits; CRC cis rs11864453 0.713 rs12708926 chr16:72126063 T/C cg01557791 chr16:72042693 DHODH -0.44 -6.14 -0.32 2.36e-9 Fibrinogen levels; CRC cis rs79976124 0.797 rs74995761 chr6:66640216 G/A cg07460842 chr6:66804631 NA 0.77 9.45 0.46 6.33e-19 Type 2 diabetes; CRC cis rs7762018 1.000 rs4716375 chr6:170071218 A/C cg19338460 chr6:170058176 WDR27 -0.76 -8.3 -0.42 2.78e-15 Thiazide-induced adverse metabolic effects in hypertensive patients; CRC cis rs7493 0.853 rs6973380 chr7:95043523 C/T cg01874867 chr7:94954059 PON1 -0.5 -6.5 -0.34 2.92e-10 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs9921222 1.000 rs10794639 chr16:377367 A/G cg08923669 chr16:420230 MRPL28 -0.45 -6.63 -0.34 1.4e-10 Bone mineral density (spine);Bone mineral density; CRC cis rs1799949 1.000 rs1060915 chr17:41234470 A/G cg25072359 chr17:41440525 NA 0.45 6.7 0.35 9.09e-11 Menopause (age at onset); CRC trans rs7618501 0.815 rs3819325 chr3:49843723 T/C cg21582582 chr3:182698605 DCUN1D1 0.52 7.44 0.38 9.11e-13 Intelligence (multi-trait analysis); CRC cis rs7726839 0.540 rs55929359 chr5:595956 C/G cg14541582 chr5:601475 NA -0.37 -7.42 -0.38 1e-12 Obesity-related traits; CRC cis rs4713118 0.513 rs149959 chr6:28013854 T/C cg03623178 chr6:28175578 NA 0.77 11.42 0.53 1.1e-25 Parkinson's disease; CRC cis rs2153535 0.580 rs1577467 chr6:8444241 G/A cg21535247 chr6:8435926 SLC35B3 0.48 7.24 0.37 3.19e-12 Motion sickness; CRC cis rs9372498 0.505 rs62424173 chr6:118780507 C/G cg15382696 chr6:118971807 C6orf204 0.59 7.5 0.38 6.18e-13 Diastolic blood pressure; CRC cis rs9291683 0.509 rs998676 chr4:9948564 T/C cg00071950 chr4:10020882 SLC2A9 -0.65 -11.96 -0.55 1.28e-27 Bone mineral density; CRC cis rs11148252 0.538 rs2897976 chr13:52715944 G/A cg12458913 chr13:53173898 NA 0.46 6.81 0.35 4.53e-11 Lewy body disease; CRC cis rs919433 0.963 rs4850429 chr2:198178409 A/G cg03934865 chr2:198174659 NA 0.44 7.04 0.36 1.16e-11 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC cis rs11098499 0.779 rs80242894 chr4:120375752 G/A cg24375607 chr4:120327624 NA 0.52 8.1 0.41 1.05e-14 Corneal astigmatism; CRC cis rs7591163 0.959 rs11685995 chr2:228722008 T/C cg22079747 chr2:228736145 WDR69 -0.41 -5.61 -0.3 4.24e-8 Blood pressure; CRC cis rs7493 0.853 rs11770901 chr7:95054480 T/C cg20119798 chr7:94954144 PON1 -0.52 -6.5 -0.34 3.03e-10 Yu-Zhi constitution type in type 2 diabetes; CRC trans rs925098 0.577 rs2724470 chr4:17996046 A/G cg15672331 chr15:85923765 AKAP13 -0.4 -6.1 -0.32 3.02e-9 Birth weight;Height; CRC cis rs780096 0.526 rs809058 chr2:27616790 T/C cg24768116 chr2:27665128 KRTCAP3 -0.35 -7.82 -0.4 7.21e-14 Total body bone mineral density; CRC cis rs13191362 0.935 rs34035978 chr6:163165336 G/C cg21926612 chr6:163149169 PACRG;PARK2 0.82 11.36 0.53 1.86e-25 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs950169 0.580 rs17598114 chr15:85171317 C/T cg17507749 chr15:85114479 UBE2QP1 0.63 8.97 0.44 2.23e-17 Schizophrenia; CRC cis rs2066819 1.000 rs11575229 chr12:56750737 C/T cg26714650 chr12:56694279 CS -1.4 -10.71 -0.51 3.55e-23 Psoriasis vulgaris; CRC cis rs477895 0.838 rs12794145 chr11:64006484 C/T cg05016508 chr11:63871570 FLRT1;MACROD1 0.53 6.53 0.34 2.52e-10 Mean platelet volume; CRC cis rs2032447 0.802 rs198853 chr6:26104096 T/C cg04800585 chr6:26043546 HIST1H2BB -0.48 -7.03 -0.36 1.21e-11 Intelligence (multi-trait analysis); CRC cis rs1577917 0.610 rs11752795 chr6:86287129 C/A cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A 0.5 6.97 0.36 1.78e-11 Response to antipsychotic treatment; CRC cis rs7412746 0.658 rs12097963 chr1:150870450 T/C cg10589385 chr1:150898437 SETDB1 0.33 7.02 0.36 1.26e-11 Melanoma; CRC cis rs2380220 0.516 rs7748108 chr6:96008082 T/C cg15832292 chr6:96025679 MANEA 0.6 7.33 0.37 1.76e-12 Behavioural disinhibition (generation interaction); CRC cis rs9322193 0.923 rs9505826 chr6:149955048 A/G cg07701084 chr6:150067640 NUP43 0.55 8.04 0.41 1.58e-14 Lung cancer; CRC cis rs12438659 1 rs12438659 chr15:78824924 G/A cg06917634 chr15:78832804 PSMA4 -0.45 -5.61 -0.3 4.24e-8 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; CRC cis rs847649 0.692 rs7800548 chr7:102481842 C/T cg18108683 chr7:102477205 FBXL13 0.66 11.07 0.52 1.99e-24 Morning vs. evening chronotype; CRC cis rs11123610 0.520 rs66557864 chr2:3720812 C/A cg10645314 chr2:3704589 ALLC -0.54 -6.39 -0.33 5.78e-10 Response to inhaled corticosteroid treatment in asthma (change in FEV1); CRC trans rs1864585 0.520 rs7817252 chr8:10685932 C/A cg26278703 chr11:58910052 FAM111A 0.51 6.03 0.32 4.33e-9 Neutrophil percentage of white cells;Lymphocyte percentage of white cells; CRC cis rs117623576 0.618 rs211413 chr10:32396902 C/A cg03047570 chr10:32398778 NA 0.68 7.58 0.39 3.63e-13 Anti-saccade response; CRC cis rs9462027 0.606 rs7756009 chr6:34715395 A/T cg07306190 chr6:34760872 UHRF1BP1 -0.35 -6.25 -0.33 1.28e-9 Systemic lupus erythematosus; CRC cis rs2836974 0.568 rs428602 chr21:40547004 A/G cg06238570 chr21:40685208 BRWD1 0.82 13.18 0.59 4e-32 Cognitive function; CRC trans rs2303319 0.582 rs56315911 chr2:162560186 G/T cg03774468 chr3:140950104 ACPL2 -0.64 -5.99 -0.31 5.37e-9 Cognitive function; CRC cis rs4523957 0.579 rs903160 chr17:2091765 C/T cg16513277 chr17:2031491 SMG6 -0.58 -9.67 -0.47 1.2e-19 Autism spectrum disorder or schizophrenia;Schizophrenia; CRC cis rs2806561 0.704 rs2746560 chr1:23526279 G/A cg12483005 chr1:23474871 LUZP1 0.49 7.0 0.36 1.46e-11 Height; CRC cis rs11608355 0.515 rs11610558 chr12:109925865 C/T cg05360138 chr12:110035743 NA 0.78 8.76 0.43 1.07e-16 Neuroticism; CRC trans rs6601327 0.607 rs13276086 chr8:9578982 T/G cg06636001 chr8:8085503 FLJ10661 -0.5 -7.27 -0.37 2.68e-12 Multiple myeloma (hyperdiploidy); CRC cis rs10540 1.000 rs35811812 chr11:498442 G/A cg19913688 chr11:428466 ANO9 -0.56 -6.09 -0.32 3.22e-9 Body mass index; CRC cis rs7044106 0.718 rs1960421 chr9:123394894 C/G cg14255062 chr9:123606675 PSMD5;LOC253039 0.44 6.36 0.33 6.77e-10 Hip circumference adjusted for BMI; CRC cis rs7249142 0.549 rs7260127 chr19:19280499 C/T cg12558012 chr19:19281197 LOC729991-MEF2B;MEF2B -0.6 -9.66 -0.47 1.37e-19 IgG glycosylation; CRC trans rs11654801 0.812 rs16962470 chr17:20854775 C/T cg23759823 chr7:139672531 TBXAS1 -0.38 -6.19 -0.32 1.78e-9 Mosquito bite size; CRC cis rs1005277 0.540 rs7903942 chr10:37929276 C/T cg00409905 chr10:38381863 ZNF37A 0.62 10.03 0.48 7.81e-21 Extrinsic epigenetic age acceleration; CRC cis rs2976388 0.609 rs1560986 chr8:143789775 T/C cg05569086 chr8:143859399 LYNX1 0.38 6.74 0.35 7.09e-11 Urinary tract infection frequency; CRC cis rs9517313 0.707 rs9517298 chr13:99095003 C/T cg20487152 chr13:99095054 FARP1 -0.49 -7.39 -0.38 1.23e-12 Neuroticism; CRC trans rs7395662 1.000 rs7949554 chr11:48581992 C/T cg21153622 chr11:89784906 NA -0.46 -7.35 -0.38 1.54e-12 HDL cholesterol; CRC cis rs7666738 0.830 rs4440224 chr4:99044924 G/A cg05340658 chr4:99064831 C4orf37 0.6 9.35 0.46 1.36e-18 Colonoscopy-negative controls vs population controls; CRC cis rs17711722 0.701 rs781145 chr7:65440370 A/C cg11764359 chr7:65958608 NA 0.52 7.9 0.4 4.32e-14 Calcium levels; CRC cis rs1448094 0.511 rs61930590 chr12:86159959 T/A cg19622623 chr12:86230825 RASSF9 -0.38 -5.78 -0.3 1.71e-8 Major depressive disorder; CRC cis rs9911578 0.935 rs6503878 chr17:56884581 T/G cg12560992 chr17:57184187 TRIM37 0.9 16.6 0.68 2.13e-45 Intelligence (multi-trait analysis); CRC cis rs9916302 0.861 rs4795377 chr17:37669056 C/T cg03013999 chr17:37608204 MED1 0.45 6.91 0.36 2.6e-11 Glomerular filtration rate (creatinine); CRC cis rs2727020 0.521 rs937430 chr11:49542457 A/G cg25886479 chr11:50257625 LOC441601 0.34 5.75 0.3 2.04e-8 Coronary artery disease; CRC cis rs6496667 1.000 rs16944254 chr15:90898527 C/T cg04176472 chr15:90893244 GABARAPL3 0.5 7.53 0.38 4.86e-13 Rheumatoid arthritis; CRC cis rs9326248 1.000 rs664922 chr11:117070895 C/A cg20608306 chr11:116969690 SIK3 0.29 5.6 0.3 4.47e-8 Blood protein levels; CRC cis rs977987 0.581 rs8056141 chr16:75497162 A/T cg03315344 chr16:75512273 CHST6 0.61 10.09 0.49 4.83e-21 Dupuytren's disease; CRC cis rs3820068 0.603 rs72647138 chr1:15980929 C/T cg27534772 chr1:16042836 PLEKHM2 0.54 10.15 0.49 3.05e-21 Systolic blood pressure; CRC cis rs7617773 0.744 rs2125482 chr3:48323133 T/G cg11946769 chr3:48343235 NME6 0.64 8.85 0.44 5.59e-17 Coronary artery disease; CRC cis rs8114671 0.836 rs6060140 chr20:33566507 G/A cg07148914 chr20:33460835 GGT7 0.36 5.72 0.3 2.43e-8 Height; CRC cis rs889312 0.500 rs252920 chr5:56148741 C/A cg24531977 chr5:56204891 C5orf35 -0.43 -6.6 -0.34 1.69e-10 Breast cancer;Breast cancer (early onset); CRC cis rs1552244 1.000 rs9820598 chr3:10117912 C/G cg13047869 chr3:10149882 C3orf24 0.53 7.53 0.38 5e-13 Alzheimer's disease; CRC cis rs7666738 0.830 rs28769113 chr4:98950371 T/G cg17366294 chr4:99064904 C4orf37 0.43 7.34 0.38 1.69e-12 Colonoscopy-negative controls vs population controls; CRC cis rs736408 0.608 rs6445534 chr3:52743384 G/A cg05573699 chr3:52720067 GNL3;PBRM1 -0.47 -6.93 -0.36 2.29e-11 Bipolar disorder; CRC cis rs2019137 0.868 rs3748916 chr2:113984033 C/T cg21550016 chr2:113992930 PAX8;LOC440839;LOC654433 -0.52 -7.46 -0.38 7.92e-13 Lymphocyte counts; CRC cis rs9682041 1.000 rs57508070 chr3:170074374 C/A cg11886554 chr3:170076028 SKIL 0.75 8.48 0.42 7.49e-16 Glomerular filtration rate in non diabetics (creatinine);Glomerular filtration rate (creatinine); CRC cis rs1538970 0.962 rs3219463 chr1:45806432 C/T cg05343316 chr1:45956843 TESK2 0.68 9.05 0.45 1.27e-17 Platelet count; CRC cis rs6952808 0.964 rs6945719 chr7:1932688 G/A cg22963979 chr7:1858916 MAD1L1 -0.52 -7.71 -0.39 1.52e-13 Bipolar disorder and schizophrenia; CRC cis rs6502050 0.835 rs66932937 chr17:80116803 G/A cg22110888 chr17:80059540 CCDC57 0.4 6.48 0.34 3.37e-10 Life satisfaction; CRC cis rs4253772 0.550 rs6007819 chr22:46704916 C/G cg03482458 chr22:46692211 CN5H6.4;GTSE1 0.5 6.13 0.32 2.48e-9 LDL cholesterol;Cholesterol, total; CRC cis rs4819052 0.851 rs4819039 chr21:46659458 G/A cg19498844 chr21:46707878 POFUT2;LOC642852 0.77 10.99 0.52 3.97e-24 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs9393692 0.620 rs9393697 chr6:26293841 C/T cg00631329 chr6:26305371 NA -0.55 -9.44 -0.46 7.12e-19 Educational attainment; CRC cis rs8180040 0.654 rs4682831 chr3:47027138 A/G cg02527881 chr3:46936655 PTH1R 0.37 6.81 0.35 4.54e-11 Colorectal cancer; CRC cis rs1448094 0.522 rs12313658 chr12:86271063 C/T cg00310523 chr12:86230176 RASSF9 0.33 5.62 0.3 4.06e-8 Major depressive disorder; CRC cis rs4144743 0.938 rs35439279 chr17:45321694 C/T cg18085866 chr17:45331354 ITGB3 -0.59 -8.01 -0.4 1.96e-14 Body mass index; CRC trans rs72991 0.740 rs297503 chr11:121264426 A/G cg27192990 chr6:129479024 LAMA2 0.4 6.63 0.34 1.41e-10 Response to tocilizumab in rheumatoid arthritis; CRC cis rs853679 0.517 rs9380050 chr6:28048538 A/G cg06470822 chr6:28175283 NA 0.98 13.17 0.59 4.07e-32 Depression; CRC trans rs8073060 0.586 rs226089 chr17:34016935 C/T cg19694781 chr19:47549865 TMEM160 -1.06 -14.24 -0.62 3.54e-36 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg22677401 chr17:46026860 NA -0.39 -5.97 -0.31 6.32e-9 Myopia (pathological); CRC cis rs7191700 0.644 rs918738 chr16:11439679 C/G cg00044050 chr16:11439710 C16orf75 -0.66 -10.04 -0.48 7.38e-21 Multiple sclerosis; CRC cis rs2361718 0.603 rs12951255 chr17:78085597 A/G cg23490090 chr17:78081364 GAA -0.34 -5.88 -0.31 1.01e-8 Yeast infection; CRC cis rs17826219 0.568 rs9903854 chr17:29153998 C/T cg13385521 chr17:29058706 SUZ12P 0.64 7.34 0.38 1.63e-12 Body mass index; CRC cis rs780096 0.526 rs72819536 chr2:27682850 G/T cg12000995 chr2:27665139 KRTCAP3 -0.32 -6.37 -0.33 6.46e-10 Total body bone mineral density; CRC cis rs7937682 0.889 rs516263 chr11:111484719 A/C cg09085632 chr11:111637200 PPP2R1B -0.98 -19.21 -0.73 1.09e-55 Primary sclerosing cholangitis; CRC cis rs10504229 1.000 rs17816781 chr8:58186161 A/T cg02290350 chr8:58132656 NA -0.42 -5.96 -0.31 6.62e-9 Developmental language disorder (linguistic errors); CRC cis rs4478858 0.684 rs4949373 chr1:31741577 G/A cg00250761 chr1:31883323 NA -0.43 -8.37 -0.42 1.68e-15 Alcohol dependence; CRC cis rs10782582 0.593 rs6664254 chr1:76235084 G/T cg03433033 chr1:76189801 ACADM -0.44 -6.4 -0.33 5.46e-10 Daytime sleep phenotypes; CRC cis rs17270561 0.609 rs4712968 chr6:25760344 T/C cg16482183 chr6:26056742 HIST1H1C 0.71 9.0 0.44 1.79e-17 Iron status biomarkers; CRC cis rs3771570 1.000 rs62193202 chr2:242303717 G/A cg21155796 chr2:242212141 HDLBP 0.65 7.02 0.36 1.29e-11 Prostate cancer; CRC cis rs709400 1.000 rs3915733 chr14:104147353 G/A cg24130564 chr14:104152367 KLC1 -0.43 -6.42 -0.33 4.68e-10 Body mass index; CRC cis rs208520 0.909 rs9453672 chr6:66991431 A/G cg07460842 chr6:66804631 NA 0.91 11.07 0.52 2.02e-24 Exhaled nitric oxide output; CRC cis rs853679 0.517 rs4713137 chr6:28083521 C/G cg03623178 chr6:28175578 NA 0.95 12.17 0.56 2.13e-28 Depression; CRC cis rs7586879 0.687 rs11892869 chr2:25096692 A/T cg04586622 chr2:25135609 ADCY3 -0.56 -10.45 -0.5 2.87e-22 Body mass index; CRC cis rs10982256 0.774 rs7034891 chr9:117245252 C/G cg13636371 chr9:117264095 DFNB31 -0.31 -5.9 -0.31 9.26e-9 Bipolar disorder; CRC cis rs514406 0.621 rs881198 chr1:53196440 C/T cg27535305 chr1:53392650 SCP2 0.34 6.04 0.32 4.09e-9 Monocyte count; CRC cis rs9287719 0.614 rs10929680 chr2:10723126 C/T cg00105475 chr2:10696890 NA 0.45 7.07 0.36 9.46e-12 Prostate cancer; CRC cis rs2839186 0.770 rs2839171 chr21:47673247 C/T cg13012494 chr21:47604986 C21orf56 -0.42 -6.66 -0.34 1.12e-10 Testicular germ cell tumor; CRC cis rs11997175 0.624 rs4733175 chr8:33679744 T/A cg04338863 chr8:33670619 NA 0.44 7.06 0.36 9.65e-12 Body mass index; CRC trans rs7395662 0.816 rs12420341 chr11:48893384 C/T cg21153622 chr11:89784906 NA -0.47 -7.42 -0.38 9.85e-13 HDL cholesterol; CRC cis rs28386778 0.897 rs2584615 chr17:61927774 T/C cg06873352 chr17:61820015 STRADA 0.73 13.62 0.6 8.27e-34 Prudent dietary pattern; CRC cis rs2302190 0.882 rs3803751 chr17:56650356 A/G cg12560992 chr17:57184187 TRIM37 0.53 6.19 0.32 1.79e-9 Vitamin D levels; CRC cis rs7412746 0.621 rs11204749 chr1:150929563 G/A cg10589385 chr1:150898437 SETDB1 0.28 5.98 0.31 5.94e-9 Melanoma; CRC cis rs3736485 0.966 rs11070856 chr15:51853817 C/T cg08986416 chr15:51914746 DMXL2 -0.45 -6.56 -0.34 2.12e-10 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs6582630 0.519 rs11181294 chr12:38312787 C/T cg26384229 chr12:38710491 ALG10B 0.69 9.77 0.47 5.73e-20 Drug-induced liver injury (flucloxacillin); CRC cis rs8180040 0.701 rs12491473 chr3:46989904 G/A cg02527881 chr3:46936655 PTH1R 0.41 7.48 0.38 6.71e-13 Colorectal cancer; CRC cis rs62064224 0.714 rs4794917 chr17:30636146 C/G cg18200150 chr17:30822561 MYO1D 0.47 9.52 0.46 3.79e-19 Schizophrenia; CRC cis rs317865 0.609 rs28619251 chr4:16172024 A/T cg04764131 chr4:16228633 TAPT1;FLJ39653 0.51 5.77 0.3 1.8e-8 Kidney disease (early stage) in type 1 diabetes; CRC cis rs1023500 0.573 rs2269524 chr22:42475703 T/G cg04733989 chr22:42467013 NAGA -0.6 -9.11 -0.45 8.21e-18 Schizophrenia; CRC cis rs763014 0.932 rs2384972 chr16:674424 G/A cg09263875 chr16:632152 PIGQ 0.79 12.79 0.58 1.13e-30 Height; CRC cis rs7113874 0.610 rs7947670 chr11:8525531 A/C cg20771178 chr11:8615675 STK33 -0.36 -5.92 -0.31 8.31e-9 Body mass index in physically active individuals;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs4363385 0.720 rs6680624 chr1:152983872 A/G cg25856811 chr1:152973957 SPRR3 -0.25 -6.77 -0.35 5.83e-11 Inflammatory skin disease; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg22783262 chr22:45098346 PRR5-ARHGAP8;PRR5 0.48 6.97 0.36 1.76e-11 Response to antipsychotic treatment; CRC cis rs9768139 0.733 rs12698209 chr7:158117595 A/G cg23298862 chr7:158159286 PTPRN2 -0.37 -5.87 -0.31 1.07e-8 Calcium levels; CRC cis rs6502050 0.769 rs8079122 chr17:80120427 G/T cg19223190 chr17:80058835 NA 0.39 6.3 0.33 9.57e-10 Life satisfaction; CRC cis rs561341 0.609 rs4795659 chr17:30187139 C/G cg12193833 chr17:30244370 NA 0.45 5.97 0.31 6.25e-9 Hip circumference adjusted for BMI; CRC cis rs12612619 0.732 rs3754734 chr2:27299598 G/T cg00617064 chr2:27272375 NA -0.39 -6.53 -0.34 2.54e-10 Venous thromboembolism adjusted for sickle cell variant rs77121243-T; CRC cis rs1550582 1.000 rs62523710 chr8:135538773 T/C cg17885191 chr8:135476712 NA 0.74 8.59 0.43 3.5e-16 Educational attainment; CRC cis rs11190604 1.000 rs57025426 chr10:102205868 A/G cg16342193 chr10:102329863 NA -0.37 -6.17 -0.32 2.02e-9 Palmitoleic acid (16:1n-7) levels; CRC cis rs736408 0.609 rs13095332 chr3:52787242 C/T cg15147215 chr3:52552868 STAB1 -0.61 -10.05 -0.48 6.91e-21 Bipolar disorder; CRC cis rs7605378 1.000 rs769957 chr2:200695524 A/C cg17644776 chr2:200775616 C2orf69 0.39 5.64 0.3 3.57e-8 Osteoporosis; CRC cis rs4713118 0.513 rs156738 chr6:28014025 G/C cg03623178 chr6:28175578 NA 0.77 11.36 0.53 1.93e-25 Parkinson's disease; CRC cis rs9611565 0.592 rs5758405 chr22:42076381 C/A cg03806693 chr22:41940476 POLR3H 0.98 12.83 0.58 8.19e-31 Vitiligo; CRC cis rs7666738 0.791 rs13128640 chr4:99003918 A/C cg17366294 chr4:99064904 C4orf37 0.44 7.39 0.38 1.19e-12 Colonoscopy-negative controls vs population controls; CRC cis rs1005277 0.579 rs2504148 chr10:38400788 A/G cg25427524 chr10:38739819 LOC399744 -0.77 -13.6 -0.6 1e-33 Extrinsic epigenetic age acceleration; CRC cis rs8105895 0.935 rs62112362 chr19:22293113 A/G cg02912127 chr19:22235281 ZNF257 -0.4 -5.6 -0.3 4.43e-8 Body mass index (change over time); CRC cis rs10504229 0.645 rs6995814 chr8:58114159 C/T cg05313129 chr8:58192883 C8orf71 -0.43 -6.0 -0.31 5.07e-9 Developmental language disorder (linguistic errors); CRC cis rs4332037 0.539 rs4470910 chr7:2071723 C/T cg23378565 chr7:2036160 MAD1L1 -0.43 -6.12 -0.32 2.73e-9 Bipolar disorder; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg09867184 chr1:153939684 SLC39A1;CREB3L4 0.48 6.5 0.34 2.89e-10 Anxiety disorder; CRC cis rs7937682 0.889 rs479667 chr11:111484034 C/T cg19812747 chr11:111475976 SIK2 -0.57 -9.75 -0.47 7e-20 Primary sclerosing cholangitis; CRC trans rs28643277 0.671 rs878321 chr10:15557115 A/G cg18315834 chr14:64909119 MTHFD1 -0.41 -5.98 -0.31 5.82e-9 Periodontitis (CDC/AAP); CRC cis rs4076764 0.957 rs4443867 chr1:163434917 T/C cg24596788 chr1:163392923 NA -0.65 -10.22 -0.49 1.83e-21 Motion sickness; CRC cis rs11641365 0.678 rs877579 chr16:88770621 A/G cg00034003 chr16:88779146 CTU2 -0.45 -5.69 -0.3 2.75e-8 Autism spectrum disorder-related traits; CRC cis rs910316 0.967 rs11159121 chr14:75666029 A/T cg11812906 chr14:75593930 NEK9 -0.51 -7.9 -0.4 4.16e-14 Height; CRC cis rs2302729 0.578 rs11062298 chr12:2771709 A/C cg19945202 chr12:2788847 CACNA1C -0.43 -6.83 -0.35 4.19e-11 Sleep quality; CRC cis rs6952808 0.792 rs12537914 chr7:1948359 C/T cg22963979 chr7:1858916 MAD1L1 -0.51 -7.52 -0.38 5.38e-13 Bipolar disorder and schizophrenia; CRC cis rs10751667 0.621 rs11246375 chr11:999620 T/C cg23136738 chr11:925521 AP2A2 -0.42 -6.48 -0.34 3.42e-10 Alzheimer's disease (late onset); CRC cis rs7264396 0.790 rs6121020 chr20:34252006 C/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.61 -10.31 -0.49 8.99e-22 Total cholesterol levels; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg00492233 chr7:135242493 NUP205 0.43 6.13 0.32 2.51e-9 Intelligence (multi-trait analysis); CRC cis rs9611565 0.512 rs2899347 chr22:42158204 T/C cg03806693 chr22:41940476 POLR3H 1.08 13.02 0.58 1.57e-31 Vitiligo; CRC cis rs7833986 1.000 rs35883156 chr8:57078933 G/T cg23139584 chr8:56987506 RPS20;SNORD54 0.62 7.44 0.38 8.99e-13 Height; CRC cis rs6681460 0.634 rs994396 chr1:67012236 G/A cg02459107 chr1:67143332 SGIP1 0.4 6.28 0.33 1.04e-9 Presence of antiphospholipid antibodies; CRC cis rs2836974 0.899 rs68004583 chr21:40659587 T/C cg17971929 chr21:40555470 PSMG1 0.83 12.42 0.57 2.6e-29 Cognitive function; CRC cis rs7894407 0.760 rs1163072 chr10:105024378 C/T cg05636881 chr10:105038444 INA -0.35 -5.67 -0.3 3.1e-8 White matter hyperintensity burden; CRC cis rs1784581 0.507 rs1790020 chr6:162366266 C/T cg17173639 chr6:162384350 PARK2 -0.6 -9.17 -0.45 5.47e-18 Itch intensity from mosquito bite; CRC cis rs250677 0.652 rs36042 chr5:148439782 G/T cg23229984 chr5:148520753 ABLIM3 0.53 6.85 0.35 3.56e-11 Breast cancer; CRC cis rs10504229 0.512 rs77289815 chr8:57995242 A/G cg22535103 chr8:58192502 C8orf71 -0.8 -7.81 -0.4 7.6e-14 Developmental language disorder (linguistic errors); CRC cis rs7177699 0.557 rs3971829 chr15:79109052 A/G cg15571903 chr15:79123663 NA 0.31 5.95 0.31 6.77e-9 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; CRC cis rs4731207 0.536 rs1904971 chr7:124669695 T/C cg23710748 chr7:124431027 NA -0.39 -6.15 -0.32 2.22e-9 Cutaneous malignant melanoma; CRC trans rs596169 0.764 rs6691014 chr1:219127338 T/C cg09853702 chr12:47665230 NA 0.77 6.43 0.33 4.58e-10 Intraocular pressure; CRC cis rs11645898 0.625 rs8047930 chr16:72106024 C/T cg14768367 chr16:72042858 DHODH -0.5 -5.83 -0.31 1.36e-8 Blood protein levels; CRC cis rs2243480 1.000 rs313824 chr7:65581207 C/T cg25985355 chr7:65971099 NA -0.49 -5.73 -0.3 2.27e-8 Diabetic kidney disease; CRC cis rs75804782 0.557 rs10178728 chr2:239360121 T/A cg18131467 chr2:239335373 ASB1 -0.64 -7.7 -0.39 1.5700000000000001e-13 Morning vs. evening chronotype;Chronotype; CRC cis rs1008375 0.966 rs6832414 chr4:17696866 C/G cg16339924 chr4:17578868 LAP3 0.49 6.63 0.34 1.39e-10 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs4737010 0.715 rs7461534 chr8:41628650 C/T cg17182837 chr8:41585554 ANK1 -0.54 -7.62 -0.39 2.72e-13 Lymphocyte counts;High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Reticulocyte count;Reticulocyte fraction of red cells;Mean corpuscular volume;Immature fraction of reticulocytes;Mean corpuscular hemoglobin concentration; CRC cis rs8014204 0.967 rs1319171 chr14:75334096 G/T cg03030879 chr14:75389066 RPS6KL1 0.55 8.77 0.44 9.78e-17 Caffeine consumption; CRC cis rs35306767 0.903 rs12761424 chr10:967295 C/T cg26597838 chr10:835615 NA 0.83 10.41 0.5 4.02e-22 Eosinophil percentage of granulocytes; CRC cis rs4285028 0.747 rs7648340 chr3:121426188 G/C cg20356878 chr3:121714668 ILDR1 -0.42 -6.01 -0.31 5.02e-9 Multiple sclerosis; CRC cis rs1552244 1.000 rs68045038 chr3:10151828 A/G cg16606324 chr3:10149918 C3orf24 0.72 9.56 0.47 2.94e-19 Alzheimer's disease; CRC cis rs1707322 0.752 rs6662164 chr1:46146230 T/A cg06784218 chr1:46089804 CCDC17 0.59 10.82 0.51 1.58e-23 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs6089584 0.888 rs6061973 chr20:60610870 C/T cg06108461 chr20:60628389 TAF4 -0.89 -15.12 -0.64 1.35e-39 Body mass index; CRC cis rs11148252 0.508 rs1886542 chr13:52706281 A/C cg02158880 chr13:53174818 NA 0.4 5.63 0.3 3.91e-8 Lewy body disease; CRC cis rs2404602 0.532 rs284892 chr15:76721037 A/G cg00316803 chr15:76480434 C15orf27 -0.37 -6.15 -0.32 2.29e-9 Blood metabolite levels; CRC cis rs6951245 1.000 rs76388414 chr7:1100694 G/A cg26224354 chr7:1096374 C7orf50;GPR146 -0.93 -12.05 -0.55 5.9e-28 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs875971 0.638 rs10249404 chr7:66046724 G/A cg18876405 chr7:65276391 NA -0.61 -11.09 -0.52 1.75e-24 Aortic root size; CRC cis rs861020 0.771 rs654470 chr1:210014093 A/T cg05527609 chr1:210001259 C1orf107 1.07 14.4 0.62 8.27e-37 Orofacial clefts; CRC cis rs10782582 0.593 rs12129523 chr1:76129223 C/A cg10523679 chr1:76189770 ACADM -0.4 -5.66 -0.3 3.28e-8 Daytime sleep phenotypes; CRC cis rs12497850 0.931 rs6414613 chr3:49035885 C/T cg20833759 chr3:49053208 WDR6;DALRD3 0.5 8.58 0.43 3.84e-16 Parkinson's disease; CRC cis rs4665809 1.000 rs4665309 chr2:26335502 T/C cg25036284 chr2:26402008 FAM59B -0.46 -5.97 -0.31 6e-9 Gut microbiome composition (summer); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg20285263 chr6:41392403 NA 0.43 6.05 0.32 3.94e-9 Response to antipsychotic treatment; CRC cis rs875971 1.000 rs4718344 chr7:65874381 C/A cg12463550 chr7:65579703 CRCP 0.48 6.96 0.36 1.89e-11 Aortic root size; CRC cis rs116095464 0.558 rs7356561 chr5:284381 G/C cg22496380 chr5:211416 CCDC127 -0.89 -10.1 -0.49 4.58e-21 Breast cancer; CRC cis rs950169 0.919 rs17300292 chr15:84762568 G/C cg03959625 chr15:84868606 LOC388152 0.42 6.33 0.33 8.21e-10 Schizophrenia; CRC cis rs972578 0.967 rs972579 chr22:43387711 T/C cg01576275 chr22:43409880 NA -0.49 -7.98 -0.4 2.48e-14 Mean platelet volume; CRC cis rs7072216 0.727 rs7913541 chr10:100172479 A/G cg26618903 chr10:100175079 PYROXD2 -0.55 -8.99 -0.44 2.03e-17 Metabolite levels; CRC cis rs4862750 0.957 rs4861733 chr4:187903933 C/T cg06074448 chr4:187884817 NA -0.61 -11.1 -0.52 1.61e-24 Lobe attachment (rater-scored or self-reported); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg07062780 chr6:112364987 NA 0.42 6.2 0.32 1.73e-9 Intelligence (multi-trait analysis); CRC cis rs8014204 0.806 rs11159105 chr14:75298052 C/T cg03030879 chr14:75389066 RPS6KL1 -0.49 -7.98 -0.4 2.38e-14 Caffeine consumption; CRC cis rs34779708 0.966 rs12775548 chr10:35479504 G/T cg03585969 chr10:35415529 CREM 0.63 8.48 0.42 7.48e-16 Inflammatory bowel disease;Crohn's disease; CRC cis rs6499129 0.558 rs60626639 chr16:67625797 A/G cg26727032 chr16:67993705 SLC12A4 -0.64 -8.47 -0.42 8.17e-16 Waist-to-hip ratio adjusted for body mass index; CRC cis rs6582630 0.533 rs4103689 chr12:38702980 A/C cg13010199 chr12:38710504 ALG10B 0.43 6.3 0.33 9.35e-10 Drug-induced liver injury (flucloxacillin); CRC cis rs7119 0.717 rs12902912 chr15:77809170 A/G cg27398640 chr15:77910606 LINGO1 -0.45 -7.75 -0.39 1.15e-13 Type 2 diabetes; CRC cis rs2361710 0.704 rs4889979 chr17:78121707 T/A cg20811857 chr17:78079795 GAA -0.41 -6.53 -0.34 2.56e-10 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count;Immature fraction of reticulocytes; CRC cis rs2991971 0.810 rs781058 chr1:45935056 C/G cg24296786 chr1:45957014 TESK2 -0.48 -7.25 -0.37 2.98e-12 High light scatter reticulocyte count; CRC cis rs2836950 0.501 rs11702505 chr21:40700614 G/T cg11644478 chr21:40555479 PSMG1 -0.44 -6.48 -0.34 3.34e-10 Menarche (age at onset); CRC cis rs4972806 0.849 rs1542180 chr2:177028767 C/T cg14324370 chr2:177042789 NA 0.8 12.98 0.58 2.09e-31 IgG glycosylation; CRC cis rs6952808 0.723 rs1107592 chr7:2041432 C/T cg04267008 chr7:1944627 MAD1L1 0.71 10.53 0.5 1.56e-22 Bipolar disorder and schizophrenia; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg20095338 chr12:76478402 NAP1L1 0.45 6.97 0.36 1.7e-11 Liver disease severity in Alagille syndrome; CRC cis rs9902453 0.726 rs3115088 chr17:28031275 A/G cg26525008 chr17:28256777 EFCAB5;SSH2 0.71 12.03 0.55 7.05e-28 Coffee consumption (cups per day); CRC cis rs12479064 0.724 rs10496336 chr2:99996165 A/G cg26064155 chr2:99771622 LIPT1;TSGA10 -0.57 -6.78 -0.35 5.5e-11 Chronic sinus infection; CRC cis rs9488822 0.596 rs13206506 chr6:116324460 A/G cg26893134 chr6:116381904 FRK 0.27 7.33 0.37 1.77e-12 Cholesterol, total;LDL cholesterol; CRC cis rs1065852 0.526 rs2413663 chr22:42402399 T/A cg00645731 chr22:42541494 CYP2D7P1 0.4 6.89 0.36 2.79e-11 Response to serotonin reuptake inhibitors in major depressive disorder (plasma drug and metabolite levels); CRC cis rs6424115 0.708 rs2076343 chr1:24129126 A/G cg10978503 chr1:24200527 CNR2 -0.43 -6.49 -0.34 3.09e-10 Immature fraction of reticulocytes; CRC cis rs1552244 0.935 rs7649243 chr3:10089470 T/A cg10729496 chr3:10149963 C3orf24 0.55 7.26 0.37 2.73e-12 Alzheimer's disease; CRC cis rs8114671 0.562 rs6119536 chr20:33450041 A/G cg07148914 chr20:33460835 GGT7 -0.39 -6.88 -0.35 2.96e-11 Height; CRC trans rs11722228 0.508 rs2241473 chr4:10085949 G/A cg26043149 chr18:55253948 FECH 1.11 17.83 0.7 3.18e-50 Gout;Urate levels;Serum uric acid levels; CRC cis rs6866344 0.570 rs11740283 chr5:178136440 T/C cg10224037 chr5:178157518 ZNF354A 0.75 11.03 0.52 2.72e-24 Neutrophil percentage of white cells; CRC trans rs853679 0.546 rs34295134 chr6:27828151 T/A cg06606381 chr12:133084897 FBRSL1 -0.75 -6.55 -0.34 2.22e-10 Depression; CRC cis rs6582630 0.555 rs10880625 chr12:38526612 A/C cg26384229 chr12:38710491 ALG10B 0.71 9.57 0.47 2.67e-19 Drug-induced liver injury (flucloxacillin); CRC cis rs9914988 0.887 rs34644886 chr17:27168327 T/C cg16670446 chr17:27188758 MIR451;MIR144 0.55 8.4 0.42 1.35e-15 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs7618915 0.547 rs11714419 chr3:52628816 A/G cg08222913 chr3:52553049 STAB1 -0.35 -6.37 -0.33 6.35e-10 Bipolar disorder; CRC cis rs9443645 0.527 rs4706743 chr6:79615793 G/T cg09184832 chr6:79620586 NA -0.46 -8.04 -0.41 1.6e-14 Intelligence (multi-trait analysis); CRC cis rs5750830 0.621 rs5757665 chr22:39821641 A/G cg25459000 chr22:39777742 SYNGR1 -0.34 -6.05 -0.32 3.91e-9 Intelligence (multi-trait analysis); CRC cis rs863345 0.526 rs863931 chr1:158612236 A/G cg12129480 chr1:158549410 OR10X1 -0.31 -6.6 -0.34 1.62e-10 Pneumococcal bacteremia; CRC cis rs17234274 0.584 rs11027058 chr11:23232320 A/G cg05245346 chr11:23248277 NA 0.36 5.84 0.31 1.23e-8 Cancer; CRC cis rs28386778 0.897 rs2665831 chr17:61912392 C/T cg11494091 chr17:61959527 GH2 0.64 10.8 0.51 1.84e-23 Prudent dietary pattern; CRC cis rs7635838 0.827 rs4273358 chr3:11415160 T/G cg00170343 chr3:11313890 ATG7 0.43 6.57 0.34 2.02e-10 HDL cholesterol; CRC cis rs10982256 0.774 rs13286452 chr9:117246574 C/T cg13636371 chr9:117264095 DFNB31 0.33 6.39 0.33 5.67e-10 Bipolar disorder; CRC cis rs17826219 0.706 rs55764512 chr17:29085758 G/A cg01831904 chr17:28903510 LRRC37B2 -0.63 -6.53 -0.34 2.51e-10 Body mass index; CRC cis rs9648716 1.000 rs6954652 chr7:140585871 A/C cg10747023 chr7:140774559 NA 0.44 5.88 0.31 9.82e-9 Type 2 diabetes; CRC cis rs2050392 0.829 rs306589 chr10:30723831 A/G cg25182066 chr10:30743637 MAP3K8 -0.41 -6.01 -0.31 5.06e-9 Inflammatory bowel disease; CRC cis rs9325144 0.602 rs10785590 chr12:38694145 C/T cg26384229 chr12:38710491 ALG10B 0.58 8.54 0.43 5.02e-16 Morning vs. evening chronotype; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg11471939 chr15:72522966 PKM2 0.43 6.16 0.32 2.1e-9 Intelligence (multi-trait analysis); CRC cis rs617791 0.508 rs1047464 chr11:65769456 A/T cg27068330 chr11:65405492 SIPA1 -0.48 -6.69 -0.35 9.69e-11 Breast cancer; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg00794038 chr20:48808334 CEBPB 0.42 6.24 0.33 1.34e-9 Intelligence (multi-trait analysis); CRC trans rs4843747 0.697 rs72818533 chr16:88073841 G/A cg26811252 chr16:29126840 RRN3P2 0.71 9.86 0.48 2.86e-20 Menopause (age at onset); CRC cis rs2243480 1.000 rs160648 chr7:65543384 C/A cg25985355 chr7:65971099 NA -0.5 -6.01 -0.31 4.91e-9 Diabetic kidney disease; CRC cis rs7927771 1.000 rs10838747 chr11:47716324 G/C cg05585544 chr11:47624801 NA -0.62 -10.93 -0.52 6.4e-24 Subjective well-being; CRC cis rs2857891 1.000 rs72845397 chr11:6950903 C/T cg26870460 chr11:6947759 ZNF215 0.56 5.88 0.31 1.01e-8 Response to cytadine analogues (cytosine arabinoside); CRC cis rs1401999 1.000 rs939336 chr3:183685534 A/G cg05044414 chr3:183734942 ABCC5 0.47 8.11 0.41 1.03e-14 Anterior chamber depth; CRC cis rs1552244 0.554 rs13079240 chr3:10047246 C/T cg00166722 chr3:10149974 C3orf24 0.43 6.36 0.33 6.73e-10 Alzheimer's disease; CRC trans rs6833159 0.527 rs10939231 chr4:28829372 A/T cg22734451 chr15:78219748 LOC645752 0.45 6.41 0.33 4.97e-10 Underweight status; CRC cis rs7927592 0.913 rs11228293 chr11:68384646 T/C cg16797656 chr11:68205561 LRP5 0.36 5.69 0.3 2.81e-8 Total body bone mineral density; CRC cis rs7215564 0.908 rs4889879 chr17:78662573 A/T cg09596252 chr17:78655493 RPTOR -0.55 -5.91 -0.31 8.47e-9 Myopia (pathological); CRC cis rs11864453 0.679 rs2303285 chr16:72124495 A/C cg23815491 chr16:72088622 HP 0.51 7.64 0.39 2.4e-13 Fibrinogen levels; CRC cis rs4654899 0.802 rs17449966 chr1:21203996 A/G cg02927042 chr1:21476669 EIF4G3 -0.47 -7.18 -0.37 4.6e-12 Superior frontal gyrus grey matter volume; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg09511246 chr2:172290755 DCAF17;METTL8 -0.43 -6.27 -0.33 1.11e-9 Myopia (pathological); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg05989628 chr6:3458053 SLC22A23 0.41 6.24 0.33 1.33e-9 Liver disease severity in Alagille syndrome; CRC cis rs2836950 0.545 rs2836959 chr21:40623668 T/G cg11644478 chr21:40555479 PSMG1 -0.49 -7.2 -0.37 4.11e-12 Menarche (age at onset); CRC cis rs16852403 0.548 rs10798602 chr1:178226439 A/G cg00404053 chr1:178313656 RASAL2 0.52 6.75 0.35 6.58e-11 Childhood ear infection; CRC trans rs9329221 0.683 rs688491 chr8:9884823 C/G cg06636001 chr8:8085503 FLJ10661 -0.55 -8.64 -0.43 2.57e-16 Neuroticism; CRC cis rs881375 0.967 rs1008381 chr9:123681116 T/C cg14255062 chr9:123606675 PSMD5;LOC253039 0.42 5.96 0.31 6.33e-9 Rheumatoid arthritis; CRC cis rs1448094 0.511 rs7968059 chr12:86163606 A/G cg18827107 chr12:86230957 RASSF9 -0.38 -5.81 -0.3 1.5e-8 Major depressive disorder; CRC cis rs9303280 0.776 rs9891174 chr17:38031802 T/A cg00129232 chr17:37814104 STARD3 -0.46 -7.24 -0.37 3.23e-12 Self-reported allergy; CRC cis rs6973256 0.583 rs2042000 chr7:133322697 T/C cg10665199 chr7:133106180 EXOC4 0.48 7.6 0.39 3.19e-13 Intelligence (multi-trait analysis); CRC cis rs12188164 0.525 rs2561665 chr5:460135 A/G cg26850624 chr5:429559 AHRR 0.51 8.67 0.43 1.99e-16 Cystic fibrosis severity; CRC cis rs1524976 0.698 rs9864728 chr3:65486793 A/C cg16238336 chr3:65465873 MAGI1 0.5 6.43 0.33 4.59e-10 PR interval; CRC cis rs6502050 0.835 rs8081783 chr17:80117388 G/A cg09264619 chr17:80180166 NA -0.35 -5.98 -0.31 5.97e-9 Life satisfaction; CRC cis rs7224685 0.501 rs1878332 chr17:3904446 G/A cg09695851 chr17:3907499 NA 0.83 16.4 0.67 1.35e-44 Type 2 diabetes; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg14591854 chr2:136287923 R3HDM1;ZRANB3 0.49 7.26 0.37 2.77e-12 Response to antipsychotic treatment; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg18043455 chr3:127771761 SEC61A1 0.43 6.08 0.32 3.35e-9 Response to antipsychotic treatment; CRC trans rs9747201 1.000 rs56283054 chr17:80135326 C/T cg07393940 chr7:158741817 NA -0.53 -7.68 -0.39 1.81e-13 Peripheral arterial disease (traffic-related air pollution interaction); CRC trans rs8002861 0.664 rs1808097 chr13:44424766 A/G cg12856521 chr11:46389249 DGKZ 0.44 7.2 0.37 4e-12 Leprosy; CRC cis rs1008375 1.000 rs10440301 chr4:17663199 G/A cg16339924 chr4:17578868 LAP3 0.55 7.09 0.36 8.12e-12 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs9443645 0.901 rs2174742 chr6:79610101 G/T cg11833968 chr6:79620685 NA -0.34 -5.97 -0.31 6.09e-9 Intelligence (multi-trait analysis); CRC cis rs9925964 0.967 rs2855475 chr16:31147548 G/A cg03418659 chr16:31128414 MYST1 -0.45 -6.59 -0.34 1.72e-10 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs684232 0.800 rs2002015 chr17:534525 G/T cg15660573 chr17:549704 VPS53 0.45 6.97 0.36 1.75e-11 Prostate cancer; CRC trans rs916888 0.821 rs199505 chr17:44859410 A/G cg22968622 chr17:43663579 NA -1.2 -15.72 -0.65 6.5e-42 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs3126085 0.935 rs4845421 chr1:152173259 G/T cg09127314 chr1:152161683 NA 0.52 6.52 0.34 2.67e-10 Atopic dermatitis; CRC trans rs875971 0.660 rs2191268 chr7:66110224 C/T cg23781003 chr4:120988207 MAD2L1 -0.39 -6.04 -0.32 4.06e-9 Aortic root size; CRC cis rs8051149 0.688 rs16943320 chr16:87870379 A/G cg01412419 chr16:87856264 NA 0.54 7.76 0.39 1.11e-13 Blood metabolite levels; CRC cis rs2625529 0.652 rs2957361 chr15:72345218 G/A cg16672083 chr15:72433130 SENP8 0.46 6.98 0.36 1.67e-11 Red blood cell count; CRC cis rs10504229 0.683 rs6982990 chr8:58115275 C/T cg22535103 chr8:58192502 C8orf71 0.65 8.99 0.44 1.92e-17 Developmental language disorder (linguistic errors); CRC cis rs10870270 0.830 rs11146269 chr10:133761820 G/A cg17892150 chr10:133769511 PPP2R2D -0.73 -10.93 -0.52 6.3e-24 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; CRC cis rs995000 0.931 rs10157265 chr1:63093617 C/T cg19896129 chr1:63156450 NA 0.41 6.41 0.33 5.18e-10 Triglyceride levels; CRC cis rs9549328 0.699 rs2993345 chr13:113617086 C/T cg25790453 chr13:113633590 MCF2L 0.44 7.66 0.39 2.15e-13 Systolic blood pressure; CRC cis rs7843479 0.601 rs6557712 chr8:21826421 C/T cg17168535 chr8:21777572 XPO7 0.58 9.91 0.48 2.01e-20 Mean corpuscular volume; CRC cis rs4780355 0.877 rs243317 chr16:11357331 G/T cg00044050 chr16:11439710 C16orf75 -0.42 -5.92 -0.31 8.12e-9 Crohn's disease and psoriasis; CRC cis rs911186 0.740 rs6938200 chr6:27231150 A/G cg12292205 chr6:26970375 C6orf41 -0.79 -8.68 -0.43 1.87e-16 Autism spectrum disorder or schizophrenia; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg01813026 chr11:809279 RPLP2 0.45 6.14 0.32 2.31e-9 Anxiety disorder; CRC cis rs7618915 0.547 rs62253703 chr3:52632357 T/C cg11645453 chr3:52864694 ITIH4 0.35 6.05 0.32 3.99e-9 Bipolar disorder; CRC cis rs9733 0.519 rs12095002 chr1:150649249 G/A cg18016565 chr1:150552671 MCL1 0.46 6.74 0.35 6.91e-11 Tonsillectomy; CRC cis rs7945718 0.967 rs11022491 chr11:12777620 A/G cg25843174 chr11:12811716 TEAD1 -0.52 -9.86 -0.48 2.88e-20 Educational attainment (years of education); CRC trans rs2303319 0.504 rs62189047 chr2:162613314 T/A cg10272801 chr16:14013773 ERCC4 -0.68 -6.07 -0.32 3.49e-9 Cognitive function; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg10337772 chr3:44803071 KIF15;KIAA1143 0.47 6.58 0.34 1.89e-10 Response to antipsychotic treatment; CRC cis rs4713118 0.869 rs6914924 chr6:27711530 C/T cg25164649 chr6:28176230 NA 0.58 8.19 0.41 5.97e-15 Parkinson's disease; CRC cis rs7727544 1.000 rs7727038 chr5:131590257 C/T cg02033258 chr5:131593261 PDLIM4 0.36 7.0 0.36 1.4e-11 Blood metabolite levels; CRC trans rs1997103 0.954 rs1997099 chr7:55405540 T/C cg20935933 chr6:143382018 AIG1 0.51 6.64 0.34 1.3e-10 QRS interval (sulfonylurea treatment interaction); CRC cis rs7811142 1.000 rs1000215 chr7:100004543 A/G cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.64 8.75 0.43 1.16e-16 Platelet count; CRC cis rs9929218 0.861 rs3114409 chr16:68732049 A/C cg02972257 chr16:68554789 NA 0.47 5.92 0.31 8.24e-9 Colorectal cancer; CRC cis rs950169 0.887 rs220333 chr15:85091133 C/T cg11189052 chr15:85197271 WDR73 0.62 9.17 0.45 5.26e-18 Schizophrenia; CRC cis rs2976388 0.506 rs2572902 chr8:143791387 A/G cg04969067 chr8:143858791 LYNX1 0.45 7.58 0.39 3.66e-13 Urinary tract infection frequency; CRC cis rs1008375 0.966 rs4698636 chr4:17632834 T/C cg02297831 chr4:17616191 MED28 0.45 5.98 0.31 5.93e-9 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs11690935 0.851 rs6731562 chr2:172798262 T/C cg13550731 chr2:172543902 DYNC1I2 -0.97 -15.37 -0.65 1.46e-40 Schizophrenia; CRC trans rs7615952 0.546 rs11717632 chr3:125321130 G/C cg00769240 chr8:12517080 NA -0.66 -7.32 -0.37 1.96e-12 Blood pressure (smoking interaction); CRC cis rs7927592 0.956 rs12281742 chr11:68303629 C/T cg16797656 chr11:68205561 LRP5 -0.39 -6.61 -0.34 1.54e-10 Total body bone mineral density; CRC cis rs7493 1.000 rs6968305 chr7:95042529 G/A cg01874867 chr7:94954059 PON1 -0.49 -6.23 -0.32 1.43e-9 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs2797160 1.000 rs13328298 chr6:126016580 G/A cg05901451 chr6:126070800 HEY2 0.39 6.06 0.32 3.66e-9 Endometrial cancer; CRC cis rs10206020 0.921 rs72776300 chr2:1571152 A/G cg12573674 chr2:1569213 NA -0.82 -10.94 -0.52 5.91e-24 IgG glycosylation; CRC trans rs1490453 0.679 rs10434129 chr4:149245455 T/A cg26605335 chr17:4689165 VMO1 -0.35 -6.02 -0.31 4.58e-9 Biochemical measures; CRC cis rs2408955 0.521 rs10875753 chr12:48557141 C/T cg15465823 chr12:48382534 COL2A1 0.38 6.36 0.33 6.94e-10 Glycated hemoglobin levels; CRC cis rs6665290 0.669 rs34267809 chr1:227176162 C/G cg10327440 chr1:227177885 CDC42BPA -0.97 -20.37 -0.75 3.02e-60 Myeloid white cell count; CRC cis rs7044106 0.762 rs1867254 chr9:123429078 C/T cg14255062 chr9:123606675 PSMD5;LOC253039 0.45 6.53 0.34 2.51e-10 Hip circumference adjusted for BMI; CRC cis rs1799949 0.965 rs35521261 chr17:41313612 A/G cg23758822 chr17:41437982 NA 0.8 13.62 0.6 8.36e-34 Menopause (age at onset); CRC cis rs13191362 1.000 rs36042757 chr6:163004744 A/C cg23758597 chr6:163146217 PARK2 -0.51 -5.91 -0.31 8.33e-9 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs189798 0.807 rs9949 chr8:8994512 A/G cg20515095 chr8:8998461 PPP1R3B -0.47 -5.81 -0.31 1.47e-8 Myopia (pathological); CRC cis rs7412746 0.621 rs11204749 chr1:150929563 G/A cg15448220 chr1:150897856 SETDB1 0.48 7.06 0.36 9.76e-12 Melanoma; CRC cis rs10504229 0.593 rs10504216 chr8:57981470 G/A cg11062466 chr8:58055876 NA 0.51 6.06 0.32 3.75e-9 Developmental language disorder (linguistic errors); CRC cis rs11212617 0.935 rs186591 chr11:108200142 T/G cg01991180 chr11:108092276 ATM;NPAT 0.41 5.94 0.31 7.36e-9 Response to metformin in type 2 diabetes (glycemic); CRC cis rs56104184 0.723 rs1058483 chr19:49407660 G/A cg21252483 chr19:49399788 TULP2 -0.43 -6.8 -0.35 5.03e-11 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; CRC cis rs60871478 0.786 rs7807878 chr7:833878 T/C cg13798912 chr7:905769 UNC84A -0.52 -5.84 -0.31 1.25e-8 Cerebrospinal P-tau181p levels; CRC cis rs4073416 0.542 rs8007497 chr14:66044476 T/C cg03016385 chr14:66212404 NA -0.44 -6.14 -0.32 2.4e-9 N-glycan levels; CRC cis rs6032067 0.929 rs6017511 chr20:43833132 C/T cg10761708 chr20:43804764 PI3 0.49 5.6 0.3 4.41e-8 Blood protein levels; CRC cis rs9399137 0.507 rs7748708 chr6:135275142 G/A cg24558204 chr6:135376177 HBS1L 0.61 8.93 0.44 2.98e-17 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; CRC cis rs7618915 0.547 rs11720432 chr3:52672742 T/C cg18099408 chr3:52552593 STAB1 -0.44 -7.1 -0.36 7.67e-12 Bipolar disorder; CRC cis rs2032447 0.831 rs9467664 chr6:26021813 A/T cg27635394 chr6:26043820 HIST1H2BB 0.44 6.3 0.33 9.65e-10 Intelligence (multi-trait analysis); CRC cis rs4319547 0.915 rs3803005 chr12:123110654 T/C cg23029597 chr12:123009494 RSRC2 -0.6 -7.78 -0.39 9.32e-14 Body mass index; CRC cis rs10504229 0.861 rs57942497 chr8:58171239 G/T cg22535103 chr8:58192502 C8orf71 -0.82 -12.27 -0.56 9.63e-29 Developmental language disorder (linguistic errors); CRC cis rs6951245 0.786 rs77943789 chr7:1140158 C/T cg20603222 chr7:1096387 C7orf50;GPR146 -0.65 -8.1 -0.41 1.1e-14 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs58688157 0.739 rs56333810 chr11:575408 C/G cg01842473 chr11:617407 IRF7;MUPCDH -0.62 -8.14 -0.41 8.36e-15 Systemic lupus erythematosus; CRC cis rs875971 1.000 rs10215948 chr7:65747786 G/A cg18876405 chr7:65276391 NA -0.52 -8.9 -0.44 3.88e-17 Aortic root size; CRC cis rs9303280 0.806 rs35569035 chr17:38035624 C/T cg11212589 chr17:38028394 ZPBP2 0.42 7.67 0.39 2e-13 Self-reported allergy; CRC cis rs11122272 0.735 rs2739506 chr1:231529183 T/G cg06096015 chr1:231504339 EGLN1 0.41 6.18 0.32 1.91e-9 Hemoglobin concentration; CRC cis rs35272691 1 rs35272691 chr17:38157841 T/C cg17467752 chr17:38218738 THRA -0.51 -7.26 -0.37 2.87e-12 White blood cell count (neutrophil); CRC cis rs8060686 0.641 rs12447640 chr16:68150527 A/G cg08314208 chr16:67682810 RLTPR -0.58 -6.23 -0.32 1.47e-9 HDL cholesterol;Metabolic syndrome; CRC trans rs1455244 0.700 rs7229302 chr18:11508904 G/T cg15030294 chr4:139936825 CCRN4L 0.42 6.52 0.34 2.58e-10 Schizophrenia; CRC cis rs6460942 1.000 rs111761262 chr7:12415916 T/C cg06484146 chr7:12443880 VWDE -0.73 -7.67 -0.39 2e-13 Coronary artery disease; CRC cis rs4713118 0.824 rs9468225 chr6:27745719 T/G cg26587870 chr6:27730563 NA -0.45 -6.59 -0.34 1.75e-10 Parkinson's disease; CRC cis rs7727544 0.904 rs58835386 chr5:131600559 A/G cg22638593 chr5:131593259 PDLIM4 0.34 6.62 0.34 1.42e-10 Blood metabolite levels; CRC cis rs6988636 1.000 rs28600861 chr8:124189063 C/T cg27053337 chr8:124217698 FAM83A 0.46 6.99 0.36 1.58e-11 Urinary uromodulin levels; CRC trans rs12478296 1.000 rs7420157 chr2:243005204 G/A cg18288967 chr1:45987694 PRDX1 0.68 7.72 0.39 1.37e-13 Obesity-related traits; CRC cis rs2985684 1.000 rs11157696 chr14:50105746 C/G cg23565292 chr14:50234668 KLHDC2 0.39 5.7 0.3 2.62e-8 Carotid intima media thickness; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg12676444 chr3:25825192 NGLY1 -0.43 -6.53 -0.34 2.44e-10 Myopia (pathological); CRC cis rs1799949 1.000 rs8176269 chr17:41213626 G/T cg23758822 chr17:41437982 NA 0.81 13.51 0.6 2.08e-33 Menopause (age at onset); CRC cis rs6712932 0.962 rs10496390 chr2:105838791 C/T cg20265528 chr2:105853269 NA -0.34 -5.69 -0.3 2.81e-8 Type 2 diabetes; CRC cis rs965469 0.895 rs6139123 chr20:3396634 C/T cg25506879 chr20:3388711 C20orf194 -0.41 -6.38 -0.33 5.94e-10 IFN-related cytopenia; CRC cis rs9916302 0.706 rs8182252 chr17:37727950 T/C cg15445000 chr17:37608096 MED1 -0.43 -8.28 -0.42 3.12e-15 Glomerular filtration rate (creatinine); CRC cis rs561341 1.000 rs542132 chr17:30307193 A/T cg00745463 chr17:30367425 LRRC37B -0.9 -9.89 -0.48 2.23e-20 Hip circumference adjusted for BMI; CRC cis rs9611565 0.512 rs1983576 chr22:42166486 G/A cg03806693 chr22:41940476 POLR3H 1.1 13.52 0.6 2e-33 Vitiligo; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg03217460 chr11:70117060 PPFIA1 0.4 6.1 0.32 2.92e-9 Liver disease severity in Alagille syndrome; CRC cis rs875971 0.862 rs2420173 chr7:65645399 A/T cg00343986 chr7:65444356 GUSB -0.42 -5.97 -0.31 6.07e-9 Aortic root size; CRC cis rs6586163 0.872 rs7082720 chr10:90742049 C/T cg13456138 chr10:90753195 FAS -0.44 -6.58 -0.34 1.84e-10 Chronic lymphocytic leukemia; CRC cis rs4563143 0.663 rs73025068 chr19:29238998 G/A cg14983838 chr19:29218262 NA 0.56 8.64 0.43 2.47e-16 Methadone dose in opioid dependence; CRC cis rs6674176 0.696 rs4448553 chr1:44411589 A/G cg12908607 chr1:44402522 ARTN -0.56 -10.15 -0.49 3.09e-21 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Cognitive ability; CRC cis rs7107174 1.000 rs9651768 chr11:77996020 C/T cg02023728 chr11:77925099 USP35 0.5 8.74 0.43 1.2e-16 Testicular germ cell tumor; CRC cis rs752010 0.684 rs10789402 chr1:42084649 A/G cg06885757 chr1:42089581 HIVEP3 0.5 9.02 0.45 1.62e-17 Lupus nephritis in systemic lupus erythematosus; CRC cis rs7212938 0.570 rs8071050 chr17:38106599 A/G cg17344932 chr17:38183730 MED24;SNORD124 -0.36 -5.76 -0.3 1.93e-8 Asthma and hay fever; CRC cis rs7615952 0.641 rs7640158 chr3:125808011 G/A cg05084668 chr3:125655381 ALG1L -0.46 -6.58 -0.34 1.91e-10 Blood pressure (smoking interaction); CRC cis rs12142240 0.698 rs68191463 chr1:46808695 T/C cg14993813 chr1:46806288 NSUN4 -0.49 -6.22 -0.32 1.5e-9 Menopause (age at onset); CRC cis rs6761276 0.899 rs11677088 chr2:113835603 A/G cg24553058 chr2:113831203 IL1F10 0.4 6.44 0.33 4.26e-10 Protein quantitative trait loci; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg05733361 chr15:85524456 PDE8A 0.47 6.65 0.34 1.25e-10 Response to antipsychotic treatment; CRC cis rs2932538 0.922 rs12401734 chr1:113071834 A/G cg22162597 chr1:113214053 CAPZA1 0.7 9.83 0.48 3.62e-20 Systolic blood pressure;Diastolic blood pressure;Hypertension;Blood pressure; CRC cis rs6747952 0.899 rs12731 chr2:239087912 G/A cg07480446 chr2:239069576 NA -0.37 -6.92 -0.36 2.38e-11 Mean corpuscular hemoglobin concentration; CRC trans rs916888 0.821 rs70602 chr17:44859715 T/C cg07870213 chr5:140052090 DND1 -0.85 -10.09 -0.49 4.88e-21 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs425277 0.606 rs16824792 chr1:2039521 G/T cg04315214 chr1:2043799 PRKCZ 0.47 8.57 0.43 3.99e-16 Height; CRC cis rs9733 0.527 rs11204694 chr1:150653391 G/A cg18016565 chr1:150552671 MCL1 0.49 7.15 0.37 5.59e-12 Tonsillectomy; CRC cis rs812925 0.893 rs778160 chr2:61557164 A/G cg10580144 chr2:61372316 C2orf74 0.3 6.08 0.32 3.31e-9 Immature fraction of reticulocytes; CRC cis rs2243480 1.000 rs778691 chr7:65873092 G/C cg25985355 chr7:65971099 NA -0.53 -5.98 -0.31 5.75e-9 Diabetic kidney disease; CRC cis rs3862030 0.720 rs11593526 chr10:104228017 G/T cg11453585 chr10:104263688 ACTR1A;SUFU -0.74 -12.61 -0.57 5.08e-30 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for body mass index; CRC cis rs754466 0.510 rs10824579 chr10:79590685 C/T cg17075019 chr10:79541650 NA -0.83 -14.77 -0.63 3.19e-38 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs7647973 0.588 rs4855848 chr3:49653457 C/T cg13072238 chr3:49761600 GMPPB -0.51 -5.86 -0.31 1.15e-8 Menarche (age at onset); CRC cis rs8060686 0.920 rs55661503 chr16:67836552 T/A cg04539111 chr16:67997858 SLC12A4 -0.48 -5.77 -0.3 1.78e-8 HDL cholesterol;Metabolic syndrome; CRC cis rs853679 0.517 rs9357061 chr6:28051772 A/G cg15786705 chr6:28176104 NA 0.74 9.47 0.46 5.74e-19 Depression; CRC cis rs9611565 0.659 rs9611610 chr22:41949259 A/G cg03806693 chr22:41940476 POLR3H -1.15 -14.99 -0.64 4.42e-39 Vitiligo; CRC trans rs7613875 0.620 rs2526747 chr3:50082914 C/G cg21665057 chr3:196295764 WDR53;FBXO45 0.44 6.32 0.33 8.51e-10 Body mass index; CRC cis rs2050392 0.590 rs17547917 chr10:30718303 G/A cg18806716 chr10:30721971 MAP3K8 -0.7 -10.25 -0.49 1.45e-21 Inflammatory bowel disease; CRC cis rs10504229 1.000 rs59797486 chr8:58174435 T/C cg01721255 chr8:58191610 C8orf71 0.44 5.77 0.3 1.84e-8 Developmental language disorder (linguistic errors); CRC cis rs7259376 0.875 rs1975175 chr19:22515239 G/C cg02657401 chr19:22469223 NA -0.37 -8.1 -0.41 1.05e-14 Menopause (age at onset); CRC cis rs8014204 0.868 rs2230237 chr14:75359670 G/A cg03030879 chr14:75389066 RPS6KL1 0.55 9.04 0.45 1.33e-17 Caffeine consumption; CRC cis rs6088580 0.601 rs6120668 chr20:33099793 A/G cg08999081 chr20:33150536 PIGU 0.63 11.63 0.54 1.96e-26 Glomerular filtration rate (creatinine); CRC cis rs7617480 0.610 rs4955420 chr3:49208865 A/G cg06212747 chr3:49208901 KLHDC8B 0.41 6.32 0.33 8.57e-10 Subjective well-being (multi-trait analysis);Menarche (age at onset); CRC trans rs11800820 0.510 rs3124120 chr1:246708990 C/T cg26885821 chr6:124125002 NKAIN2 0.38 6.14 0.32 2.32e-9 Obesity-related traits; CRC cis rs977987 0.843 rs62062568 chr16:75445324 T/C cg03315344 chr16:75512273 CHST6 0.52 8.79 0.44 8.7e-17 Dupuytren's disease; CRC cis rs9914988 0.606 rs968726 chr17:27194634 A/G cg12682573 chr17:27188876 MIR451;MIR144 0.41 6.43 0.33 4.43e-10 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs11148252 0.904 rs7321964 chr13:53040822 A/G cg02158880 chr13:53174818 NA 0.51 7.58 0.39 3.6e-13 Lewy body disease; CRC cis rs4149423 1.000 rs12620050 chr2:108919798 G/A cg06795125 chr2:108905320 SULT1C2 -0.43 -6.63 -0.34 1.42e-10 Lobe size; CRC cis rs13256369 0.802 rs11249887 chr8:8562184 T/C cg17143192 chr8:8559678 CLDN23 0.52 6.69 0.35 9.86e-11 Obesity-related traits; CRC cis rs1062746 0.502 rs76128303 chr16:87339236 T/C cg02258303 chr16:87377426 FBXO31 -0.54 -7.68 -0.39 1.85e-13 Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 2 peripheral neuropathy); CRC cis rs7617773 0.780 rs11716848 chr3:48378500 G/A cg11946769 chr3:48343235 NME6 0.74 9.91 0.48 2.03e-20 Coronary artery disease; CRC cis rs6743376 0.554 rs11123160 chr2:113836165 A/T cg24553058 chr2:113831203 IL1F10 0.6 8.06 0.41 1.47e-14 Inflammatory biomarkers; CRC trans rs1814175 0.817 rs10769641 chr11:49960141 A/G cg15704280 chr7:45808275 SEPT13 -0.97 -18.82 -0.72 3.98e-54 Height; CRC cis rs7224737 1.000 rs2240009 chr17:40283142 C/G cg00647820 chr17:40259828 DHX58 -0.46 -6.59 -0.34 1.78e-10 Fibrinogen levels; CRC cis rs62064224 0.902 rs35830939 chr17:30627564 A/C cg25809561 chr17:30822961 MYO1D 0.62 11.22 0.53 5.9e-25 Schizophrenia; CRC cis rs2933343 1.000 rs1680790 chr3:128625853 G/T cg11901034 chr3:128598214 ACAD9 -0.51 -6.12 -0.32 2.73e-9 IgG glycosylation; CRC cis rs875971 0.502 rs11769702 chr7:65720516 A/C cg18876405 chr7:65276391 NA 0.45 6.13 0.32 2.5e-9 Aortic root size; CRC cis rs1005277 0.579 rs2474571 chr10:38384639 T/G cg00409905 chr10:38381863 ZNF37A -0.68 -11.37 -0.53 1.7e-25 Extrinsic epigenetic age acceleration; CRC cis rs9814567 1.000 rs9854299 chr3:134206728 T/C cg06109529 chr3:134205091 CEP63;ANAPC13 -0.83 -12.65 -0.57 3.57e-30 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs12144094 0.882 rs10494229 chr1:120229117 A/G cg20995928 chr1:120229863 NA 0.45 6.56 0.34 2.09e-10 Height; CRC cis rs926938 0.584 rs1286561 chr1:115375428 T/C cg12756093 chr1:115239321 AMPD1 -0.58 -8.49 -0.42 7.15e-16 Autism; CRC cis rs1552244 1.000 rs9845756 chr3:10067548 G/C cg13047869 chr3:10149882 C3orf24 0.52 7.13 0.37 6.56e-12 Alzheimer's disease; CRC cis rs7811142 0.830 rs11771936 chr7:99943283 A/G cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.12 15.67 0.65 9.79e-42 Platelet count; CRC cis rs4319547 0.794 rs61954972 chr12:123074167 T/G cg23029597 chr12:123009494 RSRC2 -0.62 -7.77 -0.39 9.78e-14 Body mass index; CRC cis rs4843747 0.671 rs72818577 chr16:88111181 G/A cg17633681 chr16:88106987 BANP 0.84 15.51 0.65 4.08e-41 Menopause (age at onset); CRC trans rs57221529 0.766 rs4081846 chr5:574019 G/A cg25482853 chr8:67687455 SGK3 1.22 14.91 0.64 9.24e-39 Lung disease severity in cystic fibrosis; CRC cis rs2270875 1.000 rs8859 chr8:133025671 C/G cg24184792 chr8:132919238 EFR3A -0.61 -5.9 -0.31 9.02e-9 Response to cholinesterase inhibitors in Alzheimer's disease; CRC cis rs1448094 0.511 rs59668915 chr12:86197170 C/T cg18827107 chr12:86230957 RASSF9 -0.37 -5.95 -0.31 6.74e-9 Major depressive disorder; CRC cis rs4285028 0.948 rs13083557 chr3:121687613 G/A cg11130432 chr3:121712080 ILDR1 -0.52 -6.75 -0.35 6.81e-11 Multiple sclerosis; CRC cis rs17376456 0.877 rs7701011 chr5:93311456 G/A cg09848695 chr5:92956644 FAM172A;MIR2277 0.63 5.67 0.3 3.18e-8 Diabetic retinopathy; CRC cis rs9462027 0.628 rs9469859 chr6:34722902 A/C cg07306190 chr6:34760872 UHRF1BP1 -0.36 -6.49 -0.34 3.21e-10 Systemic lupus erythematosus; CRC cis rs6951245 0.580 rs78894484 chr7:1138721 T/G cg24642844 chr7:1081250 C7orf50 -0.48 -6.22 -0.32 1.5e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs736408 0.570 rs11130327 chr3:52793239 A/G cg07507251 chr3:52567010 NT5DC2 0.43 6.0 0.31 5.09e-9 Bipolar disorder; CRC cis rs6735179 0.688 rs6745142 chr2:1763886 A/G cg19300414 chr2:1746591 PXDN 0.34 6.14 0.32 2.41e-9 Response to antipsychotic treatment; CRC cis rs4474465 1.000 rs11237510 chr11:78173584 G/A cg27205649 chr11:78285834 NARS2 -0.48 -5.85 -0.31 1.18e-8 Alzheimer's disease (survival time); CRC cis rs6681460 1.000 rs6681460 chr1:67123057 C/T cg02459107 chr1:67143332 SGIP1 -0.48 -8.54 -0.43 5.15e-16 Presence of antiphospholipid antibodies; CRC cis rs55823223 0.564 rs936391 chr17:73847799 A/G cg08125733 chr17:73851984 WBP2 -0.72 -9.33 -0.46 1.62e-18 Psoriasis; CRC cis rs8077889 1.000 rs59044152 chr17:41888747 A/G cg25876840 chr17:41920477 NA 0.55 7.55 0.38 4.26e-13 Triglycerides; CRC cis rs2836974 0.897 rs1541102 chr21:40628765 C/T cg11890956 chr21:40555474 PSMG1 1.08 19.26 0.73 7.11e-56 Cognitive function; CRC cis rs6867032 1.000 rs61177713 chr5:2017255 G/A cg26168224 chr5:2018326 NA 1.0 18.29 0.71 4.67e-52 Gut microbiome composition (winter); CRC cis rs1448094 0.549 rs57614821 chr12:86235361 A/C cg00310523 chr12:86230176 RASSF9 0.34 5.68 0.3 3e-8 Major depressive disorder; CRC cis rs2228479 0.850 rs2238527 chr16:89840708 C/A cg06656553 chr16:89960601 TCF25 -0.71 -5.96 -0.31 6.42e-9 Skin colour saturation; CRC cis rs78456975 0.527 rs11884165 chr2:1561052 A/G cg12573674 chr2:1569213 NA -0.82 -10.49 -0.5 2.08e-22 Placebo response in major depressive disorder (% change in symptom score); CRC cis rs8030485 0.536 rs4778918 chr15:79434040 T/C cg17916960 chr15:79447300 NA 0.38 6.1 0.32 2.92e-9 Left ventricle wall thickness; CRC cis rs11148252 0.904 rs9526927 chr13:53051627 C/T cg00495681 chr13:53174319 NA 0.66 10.38 0.5 5.02e-22 Lewy body disease; CRC cis rs2576037 0.558 rs7244778 chr18:44541915 T/C cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.66 -10.37 -0.5 5.54e-22 Personality dimensions; CRC trans rs28735056 0.875 rs62103176 chr18:77623611 G/C cg03973167 chr4:185394988 IRF2 -0.45 -6.46 -0.34 3.74e-10 Schizophrenia; CRC cis rs6912958 0.702 rs2300909 chr6:88212100 G/A cg08069147 chr6:88032118 GJB7;C6orf162 -0.55 -8.19 -0.41 5.86e-15 Monocyte percentage of white cells; CRC cis rs10504229 0.511 rs16921553 chr8:57979314 T/C cg22535103 chr8:58192502 C8orf71 -0.52 -6.05 -0.32 3.99e-9 Developmental language disorder (linguistic errors); CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg07600127 chr13:30881527 KATNAL1 0.44 6.09 0.32 3.15e-9 Anxiety disorder; CRC cis rs1577917 0.740 rs9353320 chr6:86244848 C/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A 0.57 7.86 0.4 5.53e-14 Response to antipsychotic treatment; CRC cis rs3785574 0.962 rs2584628 chr17:61894578 T/C cg11494091 chr17:61959527 GH2 0.37 5.68 0.3 2.96e-8 Height; CRC cis rs3996993 0.809 rs3756982 chr6:52670444 A/T cg20803780 chr6:52668592 GSTA1 -0.37 -6.93 -0.36 2.26e-11 Hemoglobin concentration; CRC trans rs7396835 0.551 rs10750098 chr11:116705568 G/T cg17196713 chr15:62127170 NA 0.46 6.29 0.33 1.04e-9 Quantitative traits; CRC cis rs67478160 0.619 rs12878682 chr14:104233627 G/C cg08213375 chr14:104286397 PPP1R13B 0.66 13.89 0.61 7.63e-35 Schizophrenia; CRC cis rs7954584 0.626 rs12809676 chr12:122442381 C/A cg21171335 chr12:122356390 WDR66 0.4 5.96 0.31 6.5e-9 Mean corpuscular volume; CRC cis rs2019137 0.936 rs3811059 chr2:113962071 C/T cg07772999 chr2:113993052 PAX8;LOC440839;LOC654433 -0.45 -6.42 -0.33 4.89e-10 Lymphocyte counts; CRC cis rs7771547 0.573 rs664370 chr6:36393816 A/G cg04289385 chr6:36355825 ETV7 0.39 5.69 0.3 2.86e-8 Platelet distribution width; CRC cis rs2842992 0.789 rs6908680 chr6:160218209 G/T cg11366901 chr6:160182831 ACAT2 0.98 14.11 0.61 1.13e-35 Age-related macular degeneration (geographic atrophy); CRC cis rs6570726 0.935 rs454614 chr6:145832633 C/T cg23711669 chr6:146136114 FBXO30 0.68 12.16 0.56 2.33e-28 Lobe attachment (rater-scored or self-reported); CRC cis rs1865760 1.000 rs6910138 chr6:25904352 C/G cg17691542 chr6:26056736 HIST1H1C 0.56 8.39 0.42 1.45e-15 Height; CRC cis rs868036 1.000 rs4633663 chr15:68106378 G/C cg05925327 chr15:68127851 NA -0.3 -5.87 -0.31 1.04e-8 Restless legs syndrome; CRC cis rs3796352 1.000 rs13072395 chr3:52980573 T/C cg27565382 chr3:53032988 SFMBT1 0.77 6.12 0.32 2.67e-9 Immune reponse to smallpox (secreted IL-2); CRC cis rs736408 0.509 rs1108842 chr3:52720080 A/C cg07507251 chr3:52567010 NT5DC2 0.45 6.81 0.35 4.52e-11 Bipolar disorder; CRC cis rs9467711 0.651 rs17586784 chr6:25935227 C/A cg16898833 chr6:26189333 HIST1H4D 0.68 5.69 0.3 2.78e-8 Autism spectrum disorder or schizophrenia; CRC cis rs7849270 1.000 rs7020708 chr9:131885131 A/G cg13538475 chr9:131942899 NA -0.29 -5.86 -0.31 1.1e-8 Blood metabolite ratios; CRC cis rs4713118 0.614 rs9468209 chr6:27694421 C/T cg15845792 chr6:28175446 NA 0.51 7.2 0.37 4.07e-12 Parkinson's disease; CRC cis rs9300255 0.509 rs641760 chr12:123518866 T/C cg00376283 chr12:123451042 ABCB9 0.58 7.35 0.38 1.57e-12 Neutrophil percentage of white cells; CRC trans rs6550704 0.687 rs9865314 chr3:22634337 A/G cg13370280 chr6:137539688 IFNGR1 -0.4 -6.09 -0.32 3.08e-9 Daytime sleep phenotypes; CRC cis rs11585357 0.895 rs4625336 chr1:17630964 G/T cg08277548 chr1:17600880 PADI3 -0.81 -10.78 -0.51 2.12e-23 Hair shape; CRC cis rs6831352 0.918 rs1126672 chr4:100047812 G/A cg12011299 chr4:100065546 ADH4 -0.49 -9.27 -0.45 2.61e-18 Alcohol dependence; CRC cis rs6565180 0.632 rs8050812 chr16:30385837 C/T cg17640201 chr16:30407289 ZNF48 -0.8 -11.42 -0.53 1.17e-25 Tonsillectomy; CRC cis rs73206853 0.609 rs12311902 chr12:110883799 T/C cg12870014 chr12:110450643 ANKRD13A 0.7 8.9 0.44 3.95e-17 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC cis rs7945705 0.935 rs11042103 chr11:8888700 C/T cg14711859 chr11:8959438 ASCL3 -0.49 -7.92 -0.4 3.73e-14 Hemoglobin concentration; CRC cis rs28386778 0.966 rs2854206 chr17:61947203 G/A cg06873352 chr17:61820015 STRADA 0.76 14.25 0.62 3.36e-36 Prudent dietary pattern; CRC cis rs9926296 0.568 rs7203907 chr16:89833774 C/G cg04287289 chr16:89883240 FANCA 0.81 14.42 0.62 7.35e-37 Vitiligo; CRC cis rs1953600 0.870 rs2573356 chr10:81949363 C/T cg04850286 chr10:81895943 PLAC9 0.37 6.71 0.35 8.44e-11 Sarcoidosis; CRC cis rs12451471 0.637 rs7567 chr17:78093549 G/T cg21238619 chr17:78079768 GAA -0.35 -5.63 -0.3 3.91e-8 Plateletcrit;Mean corpuscular hemoglobin concentration; CRC cis rs4853012 0.838 rs6715351 chr2:74346119 G/A cg01017244 chr2:74357527 NA 0.67 9.41 0.46 8.8e-19 Gestational age at birth (maternal effect); CRC cis rs6988636 1.000 rs7002021 chr8:124185250 G/A cg27053337 chr8:124217698 FAM83A 0.45 6.84 0.35 3.77e-11 Urinary uromodulin levels; CRC trans rs1814175 0.645 rs1818895 chr11:50031523 G/T cg11707556 chr5:10655725 ANKRD33B -0.51 -9.97 -0.48 1.29e-20 Height; CRC cis rs881375 0.967 rs2270231 chr9:123650982 C/G cg00246817 chr9:123691163 NA -0.47 -5.97 -0.31 6.22e-9 Rheumatoid arthritis; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg21188454 chr9:131549455 TBC1D13 0.38 6.07 0.32 3.57e-9 Liver disease severity in Alagille syndrome; CRC cis rs11122272 0.735 rs2808596 chr1:231530723 A/G cg06096015 chr1:231504339 EGLN1 0.39 5.83 0.31 1.29e-8 Hemoglobin concentration; CRC cis rs2760061 0.626 rs596675 chr1:228117892 G/A cg02753203 chr1:228287806 NA -0.66 -10.16 -0.49 2.79e-21 Diastolic blood pressure; CRC cis rs9354308 0.933 rs10455586 chr6:66571498 T/C cg07460842 chr6:66804631 NA 0.47 5.92 0.31 8.03e-9 Metabolite levels; CRC cis rs10046574 0.731 rs10458299 chr7:135052348 C/T cg27474649 chr7:135195673 CNOT4 0.69 5.71 0.3 2.58e-8 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs2677744 0.688 rs3784779 chr15:91453131 C/T cg23684204 chr15:91497937 RCCD1 0.4 6.1 0.32 2.96e-9 Attention deficit hyperactivity disorder; CRC trans rs4263408 0.934 rs9683743 chr4:39703194 A/C cg16664537 chr13:50366648 KPNA3 -0.41 -6.03 -0.32 4.48e-9 Plasma amyloid beta peptide concentrations (ABx-40); CRC cis rs11212617 0.967 rs4585 chr11:108239628 G/T cg14761454 chr11:108092087 ATM;NPAT 0.44 6.76 0.35 6.12e-11 Response to metformin in type 2 diabetes (glycemic); CRC cis rs9296092 0.517 rs11752179 chr6:33534713 G/T cg13560919 chr6:33536144 NA -0.43 -5.95 -0.31 6.74e-9 Age at smoking initiation in chronic obstructive pulmonary disease; CRC trans rs60843830 0.928 rs55742348 chr2:217563 T/A cg11347411 chr7:150020925 ACTR3C;LRRC61 0.59 8.93 0.44 3.18e-17 Spherical equivalent (joint analysis main effects and education interaction); CRC cis rs7618915 0.501 rs3733045 chr3:52643307 A/G cg11645453 chr3:52864694 ITIH4 0.35 6.3 0.33 9.48e-10 Bipolar disorder; CRC cis rs780096 0.526 rs10182937 chr2:27651693 T/C cg02592271 chr2:27665507 KRTCAP3 -0.28 -6.44 -0.33 4.31e-10 Total body bone mineral density; CRC cis rs2834256 0.646 rs6517193 chr21:35150756 A/G cg14850771 chr21:34775459 IFNGR2 0.42 5.97 0.31 6.28e-9 Red cell distribution width; CRC cis rs6499255 0.951 rs75815213 chr16:69702854 C/T cg04110750 chr16:69646130 NFAT5 -0.56 -7.71 -0.39 1.5e-13 IgE levels; CRC cis rs12760731 0.720 rs10913557 chr1:178442190 C/T cg00404053 chr1:178313656 RASAL2 0.96 10.06 0.49 6.17e-21 Obesity-related traits; CRC cis rs4604732 0.631 rs74154672 chr1:247625625 C/G cg12754571 chr1:247694271 LOC148824;OR2C3 0.41 5.78 0.3 1.74e-8 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CRC cis rs2841277 0.708 rs10083490 chr14:105402418 A/G cg14403583 chr14:105418241 AHNAK2 0.33 5.99 0.31 5.5e-9 Rheumatoid arthritis; CRC cis rs34779708 0.733 rs4007271 chr10:35546611 C/T cg03585969 chr10:35415529 CREM 0.52 6.79 0.35 5.37e-11 Inflammatory bowel disease;Crohn's disease; CRC cis rs28386778 0.897 rs894408 chr17:61896814 C/T cg11494091 chr17:61959527 GH2 0.6 10.1 0.49 4.51e-21 Prudent dietary pattern; CRC cis rs13161895 1.000 rs864482 chr5:179427873 A/G cg02702477 chr5:179499311 RNF130 0.56 6.52 0.34 2.69e-10 LDL cholesterol; CRC cis rs4243830 1.000 rs58415361 chr1:6592377 A/G cg05709478 chr1:6581295 PLEKHG5 0.67 6.53 0.34 2.55e-10 Body mass index; CRC cis rs6570726 0.791 rs405206 chr6:145836873 C/A cg05347473 chr6:146136440 FBXO30 0.4 6.23 0.32 1.45e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs1552244 1.000 rs4269070 chr3:10126083 C/G cg08888203 chr3:10149979 C3orf24 0.71 10.1 0.49 4.55e-21 Alzheimer's disease; CRC cis rs6867032 0.917 rs10474734 chr5:2004208 A/G cg26168224 chr5:2018326 NA 0.82 12.31 0.56 6.86e-29 Gut microbiome composition (winter); CRC cis rs9905704 1.000 rs9905704 chr17:56632543 G/T cg12560992 chr17:57184187 TRIM37 -0.57 -7.88 -0.4 4.98e-14 Testicular germ cell tumor; CRC cis rs13256369 1.000 rs1109619 chr8:8571616 G/T cg18904891 chr8:8559673 CLDN23 0.5 6.76 0.35 6.33e-11 Obesity-related traits; CRC cis rs644799 0.582 rs1727149 chr11:95497171 C/T cg25622487 chr11:95524042 FAM76B;CEP57 -0.76 -12.1 -0.55 4e-28 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs1448094 0.874 rs10779219 chr12:86322643 T/G cg18827107 chr12:86230957 RASSF9 -0.37 -6.1 -0.32 2.98e-9 Major depressive disorder; CRC cis rs7633770 0.735 rs12491236 chr3:46688481 C/T cg11219411 chr3:46661640 NA -0.39 -5.69 -0.3 2.83e-8 Coronary artery disease; CRC trans rs4386084 1.000 rs117184881 chr15:50258317 A/T cg02453146 chr1:53068587 GPX7 -0.34 -6.05 -0.32 3.91e-9 Basophil percentage of white cells;Basophil percentage of granulocytes; CRC trans rs7618501 1.000 rs7618519 chr3:49772708 A/T cg21659725 chr3:3221576 CRBN -0.9 -17.3 -0.69 3.95e-48 Intelligence (multi-trait analysis); CRC cis rs17152411 0.901 rs7081640 chr10:126592522 C/T cg07906193 chr10:126599966 NA 0.49 5.96 0.31 6.64e-9 Height; CRC trans rs2243480 1.000 rs1167613 chr7:65487439 C/T cg10756647 chr7:56101905 PSPH 0.77 8.22 0.41 4.72e-15 Diabetic kidney disease; CRC cis rs875971 0.545 rs3735147 chr7:65970528 A/C cg05627663 chr7:65219948 SNORA22;CCT6P1 0.59 7.52 0.38 5.43e-13 Aortic root size; CRC cis rs1046896 0.553 rs8073413 chr17:80836005 G/A cg17346650 chr17:80929145 B3GNTL1 0.48 7.01 0.36 1.34e-11 Glycated hemoglobin levels; CRC cis rs12760731 0.623 rs10913550 chr1:178408795 A/G cg00404053 chr1:178313656 RASAL2 0.75 9.35 0.46 1.4e-18 Obesity-related traits; CRC cis rs12477438 0.798 rs9308816 chr2:99637230 A/G cg26064155 chr2:99771622 LIPT1;TSGA10 -0.78 -11.23 -0.53 5.54e-25 Chronic sinus infection; CRC cis rs2404602 0.684 rs1603860 chr15:76849591 A/T cg03037974 chr15:76606532 NA -0.51 -7.66 -0.39 2.13e-13 Blood metabolite levels; CRC cis rs12291225 0.535 rs11023203 chr11:14409815 G/A cg05501817 chr11:14380813 RRAS2 -0.42 -5.89 -0.31 9.64e-9 Sense of smell; CRC cis rs4819052 0.819 rs13046807 chr21:46672286 A/G cg11663144 chr21:46675770 NA -0.84 -14.63 -0.63 1.09e-37 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC trans rs11098499 0.863 rs13140391 chr4:120503437 A/G cg25214090 chr10:38739885 LOC399744 0.67 10.3 0.49 9.23e-22 Corneal astigmatism; CRC cis rs11122272 0.735 rs2808585 chr1:231514218 C/T cg06096015 chr1:231504339 EGLN1 0.4 5.95 0.31 6.7e-9 Hemoglobin concentration; CRC trans rs2243480 1.000 rs6974723 chr7:65637939 C/T cg10756647 chr7:56101905 PSPH -0.76 -7.87 -0.4 5.31e-14 Diabetic kidney disease; CRC cis rs4660306 0.744 rs11211115 chr1:45926438 A/T cg03123370 chr1:45965343 CCDC163P;MMACHC 0.52 6.97 0.36 1.71e-11 Homocysteine levels; CRC cis rs11764590 0.585 rs11772463 chr7:2078132 A/C cg23422044 chr7:1970798 MAD1L1 -0.54 -6.32 -0.33 8.39e-10 Neuroticism; CRC cis rs3806843 0.900 rs2337983 chr5:140136808 G/A cg16607685 chr5:140181889 PCDHA2;PCDHA1;PCDHA3 0.25 5.94 0.31 7.35e-9 Depressive symptoms (multi-trait analysis); CRC cis rs10504229 0.683 rs55637580 chr8:58135419 C/T cg24829409 chr8:58192753 C8orf71 -0.55 -8.03 -0.4 1.71e-14 Developmental language disorder (linguistic errors); CRC cis rs2243480 1.000 rs160642 chr7:65558373 C/T cg12463550 chr7:65579703 CRCP 0.68 6.55 0.34 2.22e-10 Diabetic kidney disease; CRC trans rs4843747 0.671 rs72818576 chr16:88111019 C/G cg26811252 chr16:29126840 RRN3P2 0.61 8.37 0.42 1.65e-15 Menopause (age at onset); CRC cis rs752010 0.808 rs7529858 chr1:42086606 G/C cg06885757 chr1:42089581 HIVEP3 0.51 9.11 0.45 8.4e-18 Lupus nephritis in systemic lupus erythematosus; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg17589437 chr7:87563717 ADAM22 0.39 7.06 0.36 9.93e-12 Liver disease severity in Alagille syndrome; CRC cis rs1448094 0.533 rs4412812 chr12:86151238 G/A cg02569458 chr12:86230093 RASSF9 -0.46 -7.82 -0.4 7.35e-14 Major depressive disorder; CRC cis rs11168351 0.864 rs12228750 chr12:48496997 G/A cg15465823 chr12:48382534 COL2A1 -0.38 -6.26 -0.33 1.18e-9 Bipolar disorder and schizophrenia; CRC cis rs11250464 0.736 rs5015512 chr10:1411923 T/C cg26394196 chr10:1453818 ADARB2 -0.33 -5.87 -0.31 1.04e-8 Radiation response; CRC cis rs877282 0.583 rs12356155 chr10:823940 C/T cg17470449 chr10:769945 NA 0.5 7.06 0.36 9.9e-12 Uric acid levels; CRC cis rs6121246 0.512 rs6060941 chr20:30367383 C/T cg13852791 chr20:30311386 BCL2L1 0.78 15.32 0.65 2.24e-40 Mean corpuscular hemoglobin; CRC cis rs28386778 0.863 rs4968661 chr17:61796306 A/G cg11494091 chr17:61959527 GH2 0.61 10.28 0.49 1.15e-21 Prudent dietary pattern; CRC cis rs35110281 0.782 rs1584917 chr21:45042365 A/G cg01579765 chr21:45077557 HSF2BP -0.41 -7.91 -0.4 4.03e-14 Mean corpuscular volume; CRC cis rs68170813 0.641 rs12539895 chr7:107091849 C/A cg02696742 chr7:106810147 HBP1 -0.57 -5.91 -0.31 8.42e-9 Coronary artery disease; CRC trans rs6058526 1.000 rs8118061 chr20:30741664 C/T cg13674914 chr7:14429205 DGKB -0.52 -6.13 -0.32 2.57e-9 Chronic obstructive pulmonary disease; CRC cis rs7552404 1.000 rs211718 chr1:76106675 C/T cg03433033 chr1:76189801 ACADM 0.74 10.21 0.49 1.89e-21 Blood metabolite levels;Acylcarnitine levels; CRC cis rs863345 0.625 rs11264978 chr1:158447921 T/C cg12129480 chr1:158549410 OR10X1 -0.29 -6.09 -0.32 3.07e-9 Pneumococcal bacteremia; CRC cis rs10752881 1.000 rs6658501 chr1:182991417 C/T ch.1.3577855R chr1:183094577 LAMC1 -0.85 -15.06 -0.64 2.31e-39 Colorectal cancer; CRC cis rs7043114 0.507 rs7037075 chr9:95216613 G/A cg13798575 chr9:95087839 CENPP;NOL8 -0.4 -5.81 -0.3 1.51e-8 Height; CRC cis rs11608355 0.618 rs4486687 chr12:109790741 T/A cg19025524 chr12:109796872 NA -0.62 -10.18 -0.49 2.53e-21 Neuroticism; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg03316107 chr7:5085477 RBAK 0.43 6.05 0.32 3.86e-9 Anxiety disorder; CRC cis rs875971 0.571 rs160647 chr7:65554352 C/T cg02869306 chr7:64672164 INTS4L1 0.44 6.22 0.32 1.5e-9 Aortic root size; CRC cis rs9648716 1.000 rs1267625 chr7:140536739 A/C cg10747023 chr7:140774559 NA 0.44 5.73 0.3 2.24e-8 Type 2 diabetes; CRC cis rs875971 0.895 rs7782806 chr7:65657897 C/T cg11764359 chr7:65958608 NA -0.6 -9.36 -0.46 1.25e-18 Aortic root size; CRC cis rs2120019 0.935 rs8042409 chr15:75350433 G/A cg11632617 chr15:75315747 PPCDC -0.52 -6.98 -0.36 1.61e-11 Blood trace element (Zn levels); CRC cis rs6951245 0.748 rs79658522 chr7:1095877 A/G cg21664854 chr7:1097933 C7orf50;GPR146 0.78 8.81 0.44 7.57e-17 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg20589815 chr10:47656205 NA 0.41 6.92 0.36 2.33e-11 Liver disease severity in Alagille syndrome; CRC cis rs4132509 0.793 rs10803152 chr1:243846167 C/A cg21452805 chr1:244014465 NA 0.59 7.46 0.38 7.53e-13 RR interval (heart rate); CRC cis rs847577 0.609 rs11768309 chr7:97773812 G/T cg24562669 chr7:97807699 LMTK2 0.78 17.14 0.69 1.63e-47 Breast cancer; CRC cis rs2463822 0.925 rs2513075 chr11:62102408 C/T cg06239285 chr11:62104954 ASRGL1 0.98 11.64 0.54 1.87e-26 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs2952156 0.920 rs12150298 chr17:37834541 T/C cg00129232 chr17:37814104 STARD3 -0.68 -12.01 -0.55 8.36e-28 Asthma; CRC trans rs4263408 0.934 rs9683743 chr4:39703194 A/C cg27485189 chr12:124086218 DDX55 -0.42 -6.2 -0.32 1.64e-9 Plasma amyloid beta peptide concentrations (ABx-40); CRC cis rs7589728 0.563 rs75606549 chr2:88466069 T/C cg14558114 chr2:88469736 THNSL2 0.59 6.0 0.31 5.24e-9 Plasma clusterin levels; CRC cis rs7119 1.000 rs7119 chr15:77777632 C/T cg22256960 chr15:77711686 NA -0.41 -5.95 -0.31 6.79e-9 Type 2 diabetes; CRC cis rs875971 0.660 rs3764903 chr7:66098482 G/A cg18876405 chr7:65276391 NA -0.62 -11.16 -0.52 1e-24 Aortic root size; CRC cis rs9322193 0.962 rs9322206 chr6:149962617 T/C cg13206674 chr6:150067644 NUP43 0.6 8.55 0.43 4.62e-16 Lung cancer; CRC trans rs2018683 0.584 rs4722880 chr7:28999197 C/T cg19402173 chr7:128379420 CALU -0.51 -7.67 -0.39 1.9e-13 Response to irinotecan and platinum-based chemotherapy in non-small-cell lung cancer; CRC cis rs1555322 0.530 rs2425043 chr20:33868702 T/C cg03689076 chr20:33865952 NA 0.46 6.64 0.34 1.3100000000000001e-10 Attention deficit hyperactivity disorder; CRC cis rs1552244 1.000 rs17032277 chr3:10077023 T/C cg18598329 chr3:10140678 FANCD2;C3orf24 -0.89 -11.87 -0.55 2.69e-27 Alzheimer's disease; CRC cis rs7615952 0.599 rs6803160 chr3:125709554 G/T cg18479299 chr3:125709523 NA -0.52 -6.22 -0.32 1.49e-9 Blood pressure (smoking interaction); CRC cis rs2717559 0.542 rs10956986 chr8:143886601 C/T cg04969067 chr8:143858791 LYNX1 -0.71 -12.69 -0.57 2.67e-30 Urinary tract infection frequency; CRC cis rs35306767 0.903 rs12240651 chr10:943656 A/G cg20503657 chr10:835505 NA 0.97 11.85 0.55 3.2e-27 Eosinophil percentage of granulocytes; CRC cis rs9322193 0.923 rs9322207 chr6:149978321 G/A cg00933542 chr6:150070202 PCMT1 0.31 6.32 0.33 8.47e-10 Lung cancer; CRC cis rs881375 0.933 rs7021206 chr9:123684157 A/G cg09586646 chr9:123605570 PSMD5;LOC253039 -0.45 -6.03 -0.32 4.34e-9 Rheumatoid arthritis; CRC trans rs34421088 0.560 rs1478898 chr8:11395079 G/A cg16141378 chr3:129829833 LOC729375 0.46 6.84 0.35 3.81e-11 Neuroticism; CRC cis rs6732160 0.588 rs2043101 chr2:73374050 A/G cg01422370 chr2:73384389 NA 0.38 6.05 0.32 3.86e-9 Intelligence (multi-trait analysis); CRC cis rs9911578 0.692 rs412000 chr17:56709058 G/C cg12560992 chr17:57184187 TRIM37 0.75 12.28 0.56 8.4e-29 Intelligence (multi-trait analysis); CRC cis rs2153535 0.580 rs718503 chr6:8527463 A/T cg07606381 chr6:8435919 SLC35B3 0.67 10.85 0.51 1.23e-23 Motion sickness; CRC cis rs17270561 0.609 rs6924782 chr6:25735816 C/G cg17691542 chr6:26056736 HIST1H1C 0.73 9.26 0.45 2.71e-18 Iron status biomarkers; CRC cis rs17401966 1.000 rs11121532 chr1:10277898 G/T cg19773385 chr1:10388646 KIF1B -0.56 -7.63 -0.39 2.56e-13 Hepatocellular carcinoma; CRC cis rs9534288 0.912 rs2404732 chr13:46618611 C/A cg15192986 chr13:46630673 CPB2 -0.74 -10.36 -0.5 5.94e-22 Blood protein levels; CRC cis rs853679 0.517 rs9357066 chr6:28129831 T/C cg12963246 chr6:28129442 ZNF389 0.49 5.7 0.3 2.71e-8 Depression; CRC cis rs11864453 0.826 rs2072142 chr16:72132713 C/T cg23815491 chr16:72088622 HP 0.53 8.11 0.41 1.04e-14 Fibrinogen levels; CRC cis rs7666738 0.716 rs114187620 chr4:98819534 T/A cg17366294 chr4:99064904 C4orf37 0.43 6.94 0.36 2.11e-11 Colonoscopy-negative controls vs population controls; CRC cis rs924607 0.966 rs1709554 chr5:637443 A/G cg09021430 chr5:549028 NA -0.51 -8.45 -0.42 9.25e-16 Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia; CRC cis rs9322193 0.962 rs9767122 chr6:150104689 T/G cg05861140 chr6:150128134 PCMT1 -0.43 -7.05 -0.36 1.03e-11 Lung cancer; CRC cis rs6594499 0.872 rs7723819 chr5:110427347 A/G cg04022379 chr5:110408740 TSLP -0.48 -7.55 -0.38 4.25e-13 Allergic disease (asthma, hay fever or eczema); CRC cis rs965469 0.779 rs6037568 chr20:3333245 C/T cg25506879 chr20:3388711 C20orf194 -0.37 -5.76 -0.3 1.91e-8 IFN-related cytopenia; CRC cis rs4654899 1.000 rs4654896 chr1:21356930 T/C cg02927042 chr1:21476669 EIF4G3 -0.48 -7.75 -0.39 1.14e-13 Superior frontal gyrus grey matter volume; CRC cis rs2841277 0.646 rs3742935 chr14:105405599 G/C cg15352829 chr14:105391018 PLD4 -0.5 -11.07 -0.52 2.03e-24 Rheumatoid arthritis; CRC cis rs4819052 0.851 rs2236443 chr21:46678174 T/C cg11663144 chr21:46675770 NA -0.7 -11.25 -0.53 4.79e-25 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs4665809 1.000 rs4665298 chr2:26256378 G/A cg04944784 chr2:26401820 FAM59B -0.58 -7.5 -0.38 6.08e-13 Gut microbiome composition (summer); CRC cis rs863345 0.527 rs7514555 chr1:158445138 G/T cg12129480 chr1:158549410 OR10X1 -0.29 -5.92 -0.31 8.16e-9 Pneumococcal bacteremia; CRC trans rs7301826 0.627 rs7315707 chr12:131272819 A/G cg11636714 chr8:42128950 IKBKB 0.48 6.15 0.32 2.22e-9 Plasma plasminogen activator levels; CRC cis rs10504229 0.728 rs72650858 chr8:58152832 G/A cg08219700 chr8:58056026 NA 0.45 5.74 0.3 2.11e-8 Developmental language disorder (linguistic errors); CRC cis rs58688157 0.705 rs12803132 chr11:586696 A/G cg01842473 chr11:617407 IRF7;MUPCDH -0.56 -6.45 -0.34 3.94e-10 Systemic lupus erythematosus; CRC cis rs875971 0.830 rs1167406 chr7:65556936 G/C cg12463550 chr7:65579703 CRCP -0.53 -7.55 -0.38 4.32e-13 Aortic root size; CRC cis rs9487051 0.676 rs9372208 chr6:109596168 A/G cg12927641 chr6:109611667 NA -0.36 -6.44 -0.33 4.15e-10 Reticulocyte fraction of red cells; CRC cis rs9487051 0.872 rs9487032 chr6:109605323 G/T cg21918786 chr6:109611834 NA -0.44 -8.06 -0.41 1.45e-14 Reticulocyte fraction of red cells; CRC cis rs7618915 0.570 rs11130319 chr3:52755592 A/T cg18404041 chr3:52824283 ITIH1 -0.43 -8.85 -0.44 5.68e-17 Bipolar disorder; CRC cis rs2535633 0.631 rs2257216 chr3:52968726 T/C cg15147215 chr3:52552868 STAB1 0.43 6.92 0.36 2.38e-11 Body mass index; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg15591513 chr8:142139310 DENND3 0.29 6.06 0.32 3.72e-9 Liver disease severity in Alagille syndrome; CRC cis rs4713118 0.513 rs183244 chr6:28031838 C/A cg21251018 chr6:28226885 NKAPL 0.49 7.47 0.38 7.1e-13 Parkinson's disease; CRC cis rs7909074 0.651 rs10900127 chr10:45390103 C/A cg05187965 chr10:45406764 TMEM72 -0.29 -6.28 -0.33 1.06e-9 Mean corpuscular volume; CRC cis rs561341 1.000 rs72821971 chr17:30269343 T/G cg12193833 chr17:30244370 NA -0.75 -8.76 -0.43 1.09e-16 Hip circumference adjusted for BMI; CRC trans rs208520 0.690 rs2144081 chr6:66824972 G/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.07 -14.94 -0.64 7.14e-39 Exhaled nitric oxide output; CRC cis rs7487075 0.828 rs2169030 chr12:46735056 A/C cg22049899 chr12:47219821 SLC38A4 0.33 6.45 0.34 4e-10 Itch intensity from mosquito bite; CRC cis rs11971779 0.616 rs10269683 chr7:139100868 G/A cg23387468 chr7:139079360 LUC7L2 0.41 6.97 0.36 1.74e-11 Diisocyanate-induced asthma; CRC cis rs1639906 0.893 rs13233298 chr7:2227707 C/T cg14004847 chr7:1930337 MAD1L1 -0.44 -5.86 -0.31 1.15e-8 Colonoscopy-negative controls vs population controls; CRC cis rs11758351 1.000 rs3757135 chr6:26200707 G/A cg01420254 chr6:26195488 NA 0.84 8.68 0.43 1.9e-16 Gout;Renal underexcretion gout; CRC cis rs559928 0.597 rs947939 chr11:63885287 C/T cg19465662 chr11:63993652 NUDT22;TRPT1 0.69 6.15 0.32 2.29e-9 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; CRC cis rs1448094 0.512 rs10863086 chr12:86244225 G/A cg25456477 chr12:86230367 RASSF9 0.32 5.67 0.3 3.13e-8 Major depressive disorder; CRC cis rs9910055 0.573 rs228768 chr17:42191893 A/C cg10896456 chr17:42255109 ASB16;C17orf65 0.45 7.35 0.38 1.58e-12 Total body bone mineral density; CRC cis rs11792861 0.591 rs11791855 chr9:111684139 C/T cg14432460 chr9:111696404 IKBKAP;C9orf6 0.5 7.08 0.36 9e-12 Menarche (age at onset); CRC cis rs11112613 0.938 rs2374513 chr12:106007300 C/T cg03607813 chr12:105948248 NA 0.71 7.91 0.4 4.03e-14 Corrected insulin response;Corrected insulin response adjusted for insulin sensitivity index; CRC cis rs7552404 0.727 rs1146653 chr1:76280438 A/G cg03433033 chr1:76189801 ACADM 0.67 9.24 0.45 3.1e-18 Blood metabolite levels;Acylcarnitine levels; CRC trans rs6550704 0.687 rs9865314 chr3:22634337 A/G cg02488887 chr5:176830915 F12 -0.42 -6.03 -0.32 4.38e-9 Daytime sleep phenotypes; CRC cis rs12995491 0.731 rs56188884 chr2:88508657 G/A cg04511125 chr2:88470314 THNSL2 -0.41 -5.95 -0.31 7.01e-9 Response to metformin (IC50); CRC cis rs6908034 0.607 rs113894708 chr6:19806066 G/T cg02682789 chr6:19804855 NA 0.79 6.75 0.35 6.62e-11 Endometriosis;Deep ovarian and/or rectovaginal disease with dense adhesions; CRC cis rs9287719 0.649 rs10207885 chr2:10733188 C/T cg00105475 chr2:10696890 NA 0.45 7.1 0.36 7.51e-12 Prostate cancer; CRC cis rs9788682 1.000 rs12441354 chr15:78821016 G/A cg06917634 chr15:78832804 PSMA4 -0.45 -5.6 -0.3 4.48e-8 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; CRC cis rs9457247 0.967 rs447042 chr6:167405435 C/T cg23791538 chr6:167370224 RNASET2 -0.38 -5.94 -0.31 7.32e-9 Crohn's disease; CRC cis rs300703 0.935 rs7568664 chr2:280939 A/G cg21211680 chr2:198530 NA 0.97 8.46 0.42 9.1e-16 Blood protein levels; CRC cis rs2204008 0.837 rs11181857 chr12:38413255 C/G cg26384229 chr12:38710491 ALG10B 0.67 9.44 0.46 7.17e-19 Bladder cancer; CRC cis rs7208859 0.725 rs7342938 chr17:29189830 A/G cg14008862 chr17:28927542 LRRC37B2 0.5 6.08 0.32 3.32e-9 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs739401 0.611 rs2239899 chr11:3024624 A/G cg25174290 chr11:3078921 CARS -0.46 -7.06 -0.36 9.71e-12 Longevity; CRC cis rs6502050 0.731 rs35156322 chr17:80096323 T/C cg11859384 chr17:80120422 CCDC57 -0.37 -5.85 -0.31 1.16e-8 Life satisfaction; CRC trans rs7944735 0.690 rs7927682 chr11:47947658 T/C cg15704280 chr7:45808275 SEPT13 0.52 6.07 0.32 3.56e-9 Intraocular pressure; CRC cis rs7809950 0.911 rs7778250 chr7:107224565 C/A cg23024343 chr7:107201750 COG5 0.63 9.08 0.45 1.01e-17 Coronary artery disease; CRC cis rs2075371 1.000 rs2544211 chr7:133973230 A/G cg02659138 chr7:134003124 SLC35B4 0.4 6.95 0.36 2e-11 Mean platelet volume; CRC cis rs7959452 0.901 rs1384 chr12:69747834 C/T cg14784868 chr12:69753453 YEATS4 0.67 10.39 0.5 4.82e-22 Blood protein levels; CRC trans rs2727020 0.615 rs4980435 chr11:49591576 G/A cg11707556 chr5:10655725 ANKRD33B -0.41 -7.82 -0.4 7.36e-14 Coronary artery disease; CRC cis rs7998202 0.667 rs914016 chr13:113355057 A/C cg02820901 chr13:113351484 ATP11A 0.61 6.65 0.34 1.2e-10 Glycated hemoglobin levels; CRC cis rs941898 0.957 rs941900 chr14:100603399 C/A cg14380774 chr14:101029898 BEGAIN 0.42 5.94 0.31 7.09e-9 White matter hyperintensity burden; CRC cis rs5758511 0.573 rs2267439 chr22:42237769 C/T cg00645731 chr22:42541494 CYP2D7P1 -0.37 -6.1 -0.32 2.99e-9 Birth weight; CRC cis rs7523050 0.730 rs34254854 chr1:109419875 C/T cg08274380 chr1:109419600 GPSM2 0.9 7.79 0.39 8.85e-14 Fat distribution (HIV); CRC cis rs9309473 0.528 rs2091022 chr2:73564570 G/A cg20560298 chr2:73613845 ALMS1 -0.46 -6.09 -0.32 3.11e-9 Metabolite levels; CRC cis rs6088590 0.542 rs6059956 chr20:33220070 A/G cg08999081 chr20:33150536 PIGU 0.6 11.64 0.54 1.83e-26 Coronary artery disease; CRC cis rs9462027 0.628 rs2814968 chr6:34713138 C/T cg07306190 chr6:34760872 UHRF1BP1 -0.35 -6.25 -0.33 1.28e-9 Systemic lupus erythematosus; CRC cis rs2404602 0.583 rs4381566 chr15:76589262 A/G cg00316803 chr15:76480434 C15orf27 -0.41 -7.15 -0.37 5.56e-12 Blood metabolite levels; CRC cis rs9303280 0.901 rs2952140 chr17:37928059 C/T cg00129232 chr17:37814104 STARD3 0.43 6.74 0.35 7.25e-11 Self-reported allergy; CRC cis rs9372498 0.536 rs28605789 chr6:118889952 G/A cg01339444 chr6:118972232 C6orf204 0.55 6.23 0.32 1.43e-9 Diastolic blood pressure; CRC cis rs644799 1.000 rs534497 chr11:95562868 C/G cg25622487 chr11:95524042 FAM76B;CEP57 0.76 11.99 0.55 9.59e-28 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC trans rs877282 0.898 rs11253352 chr10:766598 C/A cg22713356 chr15:30763199 NA 1.29 15.45 0.65 7.32e-41 Uric acid levels; CRC trans rs2243480 0.901 rs35087093 chr7:65405208 C/T cg10756647 chr7:56101905 PSPH 0.72 7.98 0.4 2.39e-14 Diabetic kidney disease; CRC cis rs1568889 1.000 rs7949057 chr11:28255053 A/C cg06544937 chr11:28130018 METT5D1;KIF18A 0.79 11.21 0.53 6.29e-25 Bipolar disorder; CRC cis rs929354 0.772 rs3802124 chr7:156970609 G/A cg17757837 chr7:157058334 UBE3C 0.74 12.39 0.56 3.31e-29 Body mass index; CRC cis rs4862750 0.872 rs9998172 chr4:187898773 T/C cg27532560 chr4:187881888 NA -0.56 -10.24 -0.49 1.48e-21 Lobe attachment (rater-scored or self-reported); CRC cis rs1475911 0.708 rs8129075 chr21:43523430 G/T cg19766460 chr21:43528205 UMODL1;C21orf128 0.89 12.86 0.58 6.06e-31 IgG glycosylation; CRC trans rs1455244 0.700 rs7229302 chr18:11508904 G/T cg03301945 chr19:10764555 ILF3;LOC147727 0.39 6.18 0.32 1.85e-9 Schizophrenia; CRC cis rs6582630 0.502 rs11181210 chr12:38298069 G/A cg13010199 chr12:38710504 ALG10B 0.46 6.25 0.33 1.3e-9 Drug-induced liver injury (flucloxacillin); CRC cis rs7914558 0.933 rs2066323 chr10:104871361 A/G cg04362960 chr10:104952993 NT5C2 0.59 8.9 0.44 3.71e-17 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs10504229 0.683 rs882429 chr8:58129292 A/G cg05313129 chr8:58192883 C8orf71 -0.43 -6.11 -0.32 2.74e-9 Developmental language disorder (linguistic errors); CRC cis rs6860806 0.507 rs272880 chr5:131670178 C/T cg27615366 chr5:131592974 PDLIM4 0.33 5.81 0.3 1.49e-8 Breast cancer; CRC cis rs11098499 0.955 rs1397608 chr4:120161744 A/G cg09307838 chr4:120376055 NA 0.61 9.41 0.46 8.75e-19 Corneal astigmatism; CRC cis rs736408 0.509 rs2590838 chr3:52622086 G/A cg17372223 chr3:52568218 NT5DC2 0.38 5.81 0.3 1.49e-8 Bipolar disorder; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg09560294 chr4:37892962 TBC1D1 0.5 6.62 0.34 1.44e-10 Thyroid stimulating hormone; CRC cis rs1218582 0.774 rs12036859 chr1:154859940 A/C cg09359103 chr1:154839909 KCNN3 0.77 13.29 0.59 1.42e-32 Prostate cancer; CRC cis rs2179367 0.959 rs579789 chr6:149679371 A/G cg11245181 chr6:149772854 ZC3H12D -0.4 -6.17 -0.32 2e-9 Dupuytren's disease; CRC cis rs17711722 0.503 rs453835 chr7:65511159 T/A cg00343986 chr7:65444356 GUSB -0.44 -6.03 -0.32 4.52e-9 Calcium levels; CRC cis rs6066835 0.764 rs3091617 chr20:47386290 G/T cg18078177 chr20:47281410 PREX1 0.69 6.17 0.32 2.06e-9 Multiple myeloma; CRC cis rs7927771 0.832 rs11039212 chr11:47393303 A/T cg20307385 chr11:47447363 PSMC3 0.62 9.21 0.45 3.8e-18 Subjective well-being; CRC cis rs3820068 0.603 rs7529759 chr1:15977877 A/G cg13390004 chr1:15929781 NA 0.53 7.44 0.38 9.04e-13 Systolic blood pressure; CRC cis rs6570726 0.537 rs1280279 chr6:145884048 G/T cg05347473 chr6:146136440 FBXO30 0.5 6.69 0.35 9.63e-11 Lobe attachment (rater-scored or self-reported); CRC cis rs3820068 0.580 rs34426856 chr1:16006315 C/T cg27534772 chr1:16042836 PLEKHM2 0.56 10.64 0.51 6.42e-23 Systolic blood pressure; CRC cis rs4665809 1.000 rs4233709 chr2:26291493 C/T cg22920501 chr2:26401640 FAM59B 0.49 6.73 0.35 7.69e-11 Gut microbiome composition (summer); CRC cis rs523522 0.885 rs524735 chr12:121022099 T/C cg12219531 chr12:120966889 COQ5 0.69 9.24 0.45 3.21e-18 High light scatter reticulocyte count; CRC cis rs1538970 0.816 rs10789464 chr1:45959102 C/T cg05343316 chr1:45956843 TESK2 0.74 9.7 0.47 9.57e-20 Platelet count; CRC trans rs875033 0.636 rs2818088 chr6:68287081 T/A cg00112309 chr8:106787982 ZFPM2 -0.41 -6.01 -0.31 4.97e-9 Response to amphetamines; CRC cis rs2070488 1.000 rs762317 chr3:38497659 A/G cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.91 17.03 0.68 4.35e-47 Electrocardiographic conduction measures; CRC cis rs2075371 0.865 rs2544172 chr7:133931338 T/C cg02659138 chr7:134003124 SLC35B4 0.34 5.8 0.3 1.57e-8 Mean platelet volume; CRC cis rs2120019 1.000 rs7162900 chr15:75368017 T/C cg09165964 chr15:75287851 SCAMP5 -0.79 -12.5 -0.57 1.36e-29 Blood trace element (Zn levels); CRC cis rs4363385 0.740 rs1697428 chr1:153015761 C/A cg25856811 chr1:152973957 SPRR3 -0.27 -7.47 -0.38 7.2e-13 Inflammatory skin disease; CRC cis rs9894429 0.634 rs11655346 chr17:79572399 A/G cg18240062 chr17:79603768 NPLOC4 -0.49 -7.72 -0.39 1.45e-13 Eye color traits; CRC cis rs11098499 0.754 rs12711071 chr4:120240934 A/G cg09307838 chr4:120376055 NA 0.63 9.63 0.47 1.67e-19 Corneal astigmatism; CRC cis rs763121 0.853 rs4821811 chr22:39075145 C/T cg06544989 chr22:39130855 UNC84B 0.46 6.99 0.36 1.53e-11 Menopause (age at onset); CRC cis rs12044355 0.827 rs11583715 chr1:231829039 C/T cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.48 -6.67 -0.34 1.11e-10 Alzheimer's disease; CRC cis rs6502050 0.871 rs62079994 chr17:80076516 T/C cg02741985 chr17:80059408 CCDC57 -0.45 -7.4 -0.38 1.17e-12 Life satisfaction; CRC cis rs7666738 0.893 rs11729640 chr4:99052699 C/T cg05340658 chr4:99064831 C4orf37 0.6 9.35 0.46 1.4e-18 Colonoscopy-negative controls vs population controls; CRC cis rs7216064 0.906 rs78452260 chr17:65848522 G/T cg12091567 chr17:66097778 LOC651250 -0.67 -7.59 -0.39 3.28e-13 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CRC cis rs2033711 0.783 rs8113810 chr19:58932106 A/G cg00825309 chr19:58991885 ZNF446 -0.46 -6.78 -0.35 5.7e-11 Uric acid clearance; CRC cis rs2481665 0.617 rs12732781 chr1:62518459 T/C cg18591186 chr1:62594603 INADL -0.44 -6.27 -0.33 1.15e-9 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs394563 0.556 rs398159 chr6:149792768 T/C cg11245181 chr6:149772854 ZC3H12D -0.48 -7.48 -0.38 6.92e-13 Dupuytren's disease; CRC cis rs2019137 1.000 rs2019137 chr2:113973632 G/A cg12889195 chr2:113992843 PAX8;LOC440839;LOC654433 -0.52 -7.41 -0.38 1.09e-12 Lymphocyte counts; CRC cis rs28386778 0.897 rs2597634 chr17:61878144 G/A cg22520471 chr17:61851767 DDX42;CCDC47 0.75 11.65 0.54 1.65e-26 Prudent dietary pattern; CRC cis rs9457247 0.967 rs1794696 chr6:167396174 T/C cg23791538 chr6:167370224 RNASET2 -0.37 -5.74 -0.3 2.2e-8 Crohn's disease; CRC cis rs3858526 0.523 rs10769287 chr11:5884845 T/C cg05234568 chr11:5960015 NA -0.66 -9.78 -0.47 5.44e-20 DNA methylation (variation); CRC trans rs7615952 0.932 rs9841157 chr3:125635655 C/A cg07211511 chr3:129823064 LOC729375 -1.2 -18.39 -0.71 1.85e-52 Blood pressure (smoking interaction); CRC cis rs3204270 0.639 rs11871678 chr17:79654285 G/A cg09655341 chr17:79618100 PDE6G 0.59 6.82 0.35 4.44e-11 Dental caries; CRC cis rs6681460 0.966 rs4655650 chr1:67142286 A/G cg02459107 chr1:67143332 SGIP1 0.45 7.8 0.4 8.15e-14 Presence of antiphospholipid antibodies; CRC cis rs73200209 0.744 rs17426970 chr12:116665099 T/C cg01776926 chr12:116560359 MED13L -0.61 -7.02 -0.36 1.3e-11 Total body bone mineral density; CRC cis rs72615157 0.561 rs113401658 chr7:99858505 C/T cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.49 5.84 0.31 1.27e-8 Lung function (FEV1/FVC); CRC cis rs10504229 0.565 rs7010503 chr8:58147127 G/A cg21724239 chr8:58056113 NA 0.42 6.1 0.32 2.95e-9 Developmental language disorder (linguistic errors); CRC cis rs2070677 0.935 rs2864985 chr10:135348757 C/G cg20169779 chr10:135381914 SYCE1 0.81 11.48 0.53 6.81e-26 Gout; CRC cis rs2625529 0.824 rs7182776 chr15:72462831 A/G cg16672083 chr15:72433130 SENP8 0.42 6.11 0.32 2.8e-9 Red blood cell count; CRC cis rs13108904 0.901 rs4974594 chr4:1300480 C/T cg24560729 chr4:1342394 KIAA1530 -0.33 -5.89 -0.31 9.71e-9 Obesity-related traits; CRC cis rs1868673 1.000 rs6770424 chr3:150174304 A/G cg04908077 chr3:150187338 NA -0.33 -5.64 -0.3 3.62e-8 Waist circumference; CRC cis rs6952808 0.630 rs1860832 chr7:2161849 G/A cg21782813 chr7:2030301 MAD1L1 0.55 9.68 0.47 1.12e-19 Bipolar disorder and schizophrenia; CRC cis rs7666738 0.830 rs6532701 chr4:98745134 C/T cg05340658 chr4:99064831 C4orf37 0.55 8.21 0.41 5.2e-15 Colonoscopy-negative controls vs population controls; CRC cis rs870825 0.616 rs2130393 chr4:185642335 T/C cg04058563 chr4:185651563 MLF1IP 0.73 9.54 0.47 3.27e-19 Blood protein levels; CRC trans rs853679 0.546 rs200977 chr6:27854301 T/C cg06606381 chr12:133084897 FBRSL1 -0.82 -6.93 -0.36 2.29e-11 Depression; CRC cis rs35264875 1.000 rs72928652 chr11:68851547 G/A cg01993067 chr11:68851601 TPCN2 0.56 6.33 0.33 7.99e-10 Blond vs. brown hair color; CRC cis rs9768139 0.733 rs12698209 chr7:158117595 A/G cg25566285 chr7:158114605 PTPRN2 -0.48 -7.87 -0.4 5.31e-14 Calcium levels; CRC cis rs637571 0.510 rs3903072 chr11:65583066 G/T cg26695010 chr11:65641043 EFEMP2 0.48 7.33 0.37 1.84e-12 Eosinophil percentage of white cells; CRC cis rs9928842 0.771 rs4888363 chr16:75277344 A/T cg08657710 chr16:75258780 CTRB1 -0.54 -6.97 -0.36 1.69e-11 Alcoholic chronic pancreatitis; CRC cis rs1971256 0.500 rs3912291 chr6:151818210 G/A cg14416726 chr6:151773293 C6orf211;RMND1 -0.63 -5.74 -0.3 2.11e-8 Endometriosis; CRC cis rs10504229 0.683 rs55986917 chr8:58137210 C/T cg05313129 chr8:58192883 C8orf71 -0.43 -6.11 -0.32 2.74e-9 Developmental language disorder (linguistic errors); CRC cis rs896854 0.967 rs1320164 chr8:95960767 G/A cg09323728 chr8:95962352 TP53INP1 -0.42 -6.79 -0.35 5.16e-11 Type 2 diabetes; CRC cis rs9858542 0.953 rs11922013 chr3:49458355 G/C cg00383909 chr3:49044727 WDR6 0.44 5.75 0.3 2.02e-8 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs1707322 1.000 rs6693336 chr1:46354595 C/T cg06784218 chr1:46089804 CCDC17 0.52 9.12 0.45 7.89e-18 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC trans rs1555895 0.576 rs10904571 chr10:850762 A/G cg16899823 chr10:58121153 ZWINT -0.39 -6.09 -0.32 3.2e-9 Survival in rectal cancer; CRC cis rs7829975 0.623 rs10087493 chr8:8373557 A/G cg06636001 chr8:8085503 FLJ10661 -0.45 -6.69 -0.35 9.67e-11 Mood instability; CRC cis rs6460942 1.000 rs6970095 chr7:12403840 G/A cg06484146 chr7:12443880 VWDE -0.76 -7.8 -0.4 8.09e-14 Coronary artery disease; CRC trans rs2565722 0.622 rs10945704 chr6:161290926 C/T cg01698392 chr17:76871734 TIMP2 -0.46 -6.02 -0.31 4.66e-9 Blood protein levels; CRC cis rs7493 0.853 rs11770901 chr7:95054480 T/C cg04155289 chr7:94953770 PON1 -0.63 -7.75 -0.39 1.17e-13 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs6502050 0.835 rs56095560 chr17:80151304 C/T cg13198984 chr17:80129470 CCDC57 0.43 7.56 0.38 3.92e-13 Life satisfaction; CRC cis rs1451375 0.698 rs68143668 chr7:50638110 C/T cg14593290 chr7:50529359 DDC 0.51 7.0 0.36 1.45e-11 Malaria; CRC cis rs2404602 0.710 rs2469541 chr15:76562118 C/T cg03037974 chr15:76606532 NA -0.66 -11.68 -0.54 1.33e-26 Blood metabolite levels; CRC cis rs789859 1.000 rs789862 chr3:194404522 C/T cg21106136 chr3:194405973 FAM43A 0.44 6.5 0.34 3.04e-10 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; CRC cis rs9733 0.596 rs11204697 chr1:150658971 C/T cg17724175 chr1:150552817 MCL1 0.58 9.4 0.46 9.25e-19 Tonsillectomy; CRC cis rs7914558 0.966 rs1591915 chr10:104646849 C/T cg04362960 chr10:104952993 NT5C2 0.59 8.94 0.44 2.77e-17 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC trans rs7618501 0.602 rs2624853 chr3:50128893 A/G cg21665057 chr3:196295764 WDR53;FBXO45 -0.58 -9.35 -0.46 1.43e-18 Intelligence (multi-trait analysis); CRC cis rs2976388 0.533 rs12543368 chr8:143819450 T/C cg24046110 chr8:143859143 LYNX1 -0.43 -6.62 -0.34 1.48e-10 Urinary tract infection frequency; CRC trans rs7615952 0.546 rs2922197 chr3:125322032 G/A cg02007433 chr3:129722099 NA -0.51 -6.2 -0.32 1.67e-9 Blood pressure (smoking interaction); CRC cis rs1348850 0.567 rs3821006 chr2:178537694 G/A cg22681709 chr2:178499509 PDE11A -0.44 -8.16 -0.41 7.37e-15 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg18185028 chr3:154042079 DHX36 0.35 6.07 0.32 3.45e-9 Liver disease severity in Alagille syndrome; CRC cis rs9326248 0.861 rs4938352 chr11:117027481 G/A cg26566898 chr11:117069891 TAGLN 0.38 6.91 0.36 2.53e-11 Blood protein levels; CRC cis rs2204008 0.713 rs2320522 chr12:38251438 C/T cg26384229 chr12:38710491 ALG10B 0.69 9.22 0.45 3.69e-18 Bladder cancer; CRC cis rs394563 0.726 rs366905 chr6:149735097 T/A cg07828024 chr6:149772892 ZC3H12D -0.49 -9.21 -0.45 3.97e-18 Dupuytren's disease; CRC cis rs2075671 0.903 rs11520986 chr7:100276994 A/G cg20848291 chr7:100343083 ZAN -0.67 -10.31 -0.49 9.02e-22 Other erythrocyte phenotypes; CRC cis rs2302190 0.882 rs9903173 chr17:56607358 C/T cg12560992 chr17:57184187 TRIM37 0.52 6.2 0.32 1.65e-9 Vitamin D levels; CRC cis rs7249142 0.562 rs10854009 chr19:19284705 A/C cg12558012 chr19:19281197 LOC729991-MEF2B;MEF2B 0.53 8.36 0.42 1.81e-15 IgG glycosylation; CRC cis rs11212617 0.967 rs396552 chr11:108221483 G/C cg14761454 chr11:108092087 ATM;NPAT 0.39 5.61 0.3 4.3e-8 Response to metformin in type 2 diabetes (glycemic); CRC cis rs875971 0.638 rs10278816 chr7:66036987 T/C cg18876405 chr7:65276391 NA -0.6 -10.83 -0.51 1.4e-23 Aortic root size; CRC cis rs9733 0.596 rs6587516 chr1:150623221 C/T cg10589385 chr1:150898437 SETDB1 0.28 5.98 0.31 5.86e-9 Tonsillectomy; CRC cis rs1153858 1.000 rs12439274 chr15:45636667 A/G cg10760299 chr15:45669010 GATM 0.5 8.05 0.41 1.54e-14 Homoarginine levels; CRC cis rs12699477 0.545 rs117125814 chr7:1910681 T/G cg22963979 chr7:1858916 MAD1L1 -0.47 -7.34 -0.37 1.72e-12 Testicular germ cell tumor; CRC cis rs7107174 1.000 rs2256051 chr11:77920457 G/A cg02023728 chr11:77925099 USP35 0.5 8.34 0.42 2e-15 Testicular germ cell tumor; CRC cis rs1506636 1.000 rs2259457 chr7:123424350 A/G cg03229431 chr7:123269106 ASB15 0.73 11.68 0.54 1.34e-26 Plateletcrit;Platelet count; CRC cis rs2692947 0.696 rs2576437 chr2:96800417 T/C cg23100626 chr2:96804247 ASTL 0.29 8.04 0.41 1.63e-14 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; CRC cis rs73200209 0.744 rs61939697 chr12:116555491 T/C cg01776926 chr12:116560359 MED13L -0.62 -7.41 -0.38 1.06e-12 Total body bone mineral density; CRC cis rs8114671 0.562 rs8117491 chr20:33510120 T/C cg07148914 chr20:33460835 GGT7 0.44 7.02 0.36 1.31e-11 Height; CRC cis rs367943 1.000 rs348948 chr5:112822452 A/C cg12552261 chr5:112820674 MCC -0.5 -7.66 -0.39 2.11e-13 Type 2 diabetes; CRC cis rs9868809 0.505 rs13063223 chr3:48750340 G/A cg07636037 chr3:49044803 WDR6 -0.68 -6.53 -0.34 2.57e-10 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; CRC cis rs9388451 0.839 rs4897155 chr6:126095144 C/A cg05901451 chr6:126070800 HEY2 -0.65 -11.23 -0.53 5.35e-25 Brugada syndrome; CRC cis rs6088590 0.523 rs6059913 chr20:33143288 G/A cg24642439 chr20:33292090 TP53INP2 0.41 7.1 0.36 7.93e-12 Coronary artery disease; CRC cis rs10504229 1.000 rs78953746 chr8:58170608 A/G cg05313129 chr8:58192883 C8orf71 -0.47 -6.99 -0.36 1.51e-11 Developmental language disorder (linguistic errors); CRC cis rs1904096 0.506 rs2632412 chr4:95149319 A/C cg11021082 chr4:95130006 SMARCAD1 0.48 7.06 0.36 9.8e-12 Type 2 diabetes; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg19078334 chr9:113019254 TXN 0.47 6.14 0.32 2.31e-9 Anxiety disorder; CRC cis rs6429082 0.755 rs291372 chr1:235694106 G/C cg26050004 chr1:235667680 B3GALNT2 0.59 8.71 0.43 1.54e-16 Adiposity; CRC cis rs2739330 0.828 rs4820572 chr22:24250355 T/C cg10150615 chr22:24372951 LOC391322 -0.63 -9.48 -0.46 5.11e-19 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs7586879 0.828 rs9631061 chr2:25109804 C/T cg22495460 chr2:25135724 ADCY3 -0.88 -15.34 -0.65 1.9e-40 Body mass index; CRC trans rs8073060 0.586 rs7217533 chr17:34015876 A/G cg19694781 chr19:47549865 TMEM160 -1.06 -14.24 -0.62 3.54e-36 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; CRC cis rs7666738 0.830 rs2015828 chr4:98984594 A/G cg05340658 chr4:99064831 C4orf37 0.6 9.16 0.45 5.89e-18 Colonoscopy-negative controls vs population controls; CRC cis rs9467711 0.523 rs9379853 chr6:26357635 A/G cg16898833 chr6:26189333 HIST1H4D 0.75 6.55 0.34 2.26e-10 Autism spectrum disorder or schizophrenia; CRC cis rs514406 0.571 rs11206004 chr1:53210958 G/A cg24675658 chr1:53192096 ZYG11B 0.7 11.56 0.54 3.56e-26 Monocyte count; CRC cis rs9549260 0.664 rs9532575 chr13:41225361 G/C cg21288729 chr13:41239152 FOXO1 0.49 7.63 0.39 2.54e-13 Red blood cell count; CRC cis rs11190604 1.000 rs10883500 chr10:102238324 T/G cg07080220 chr10:102295463 HIF1AN 0.48 5.79 0.3 1.61e-8 Palmitoleic acid (16:1n-7) levels; CRC trans rs11098499 0.913 rs56122576 chr4:120129336 A/G cg25214090 chr10:38739885 LOC399744 0.51 7.72 0.39 1.41e-13 Corneal astigmatism; CRC cis rs7605827 0.930 rs11896745 chr2:15515373 C/T cg19274914 chr2:15703543 NA 0.38 5.76 0.3 1.92e-8 Educational attainment (years of education); CRC cis rs28830936 1.000 rs2412622 chr15:41960311 A/G cg17847044 chr15:42102381 MAPKBP1 -0.29 -6.2 -0.32 1.68e-9 Diastolic blood pressure; CRC cis rs7122539 0.839 rs6591223 chr11:66609289 C/T cg24851651 chr11:66362959 CCS 0.43 7.68 0.39 1.9e-13 HIV-1 susceptibility; CRC cis rs2455601 1.000 rs72632952 chr11:8917976 T/C cg21881798 chr11:8931708 C11orf17;ST5 -0.55 -6.15 -0.32 2.27e-9 Schizophrenia; CRC cis rs2658782 0.951 rs2608215 chr11:93148817 G/A cg15737290 chr11:93063684 CCDC67 0.5 7.36 0.38 1.51e-12 Pulmonary function decline; CRC cis rs10504229 0.683 rs67048677 chr8:58140023 C/G cg04204079 chr8:58130323 NA -0.45 -5.78 -0.3 1.71e-8 Developmental language disorder (linguistic errors); CRC cis rs12681287 0.640 rs10086340 chr8:87446789 G/T cg27223183 chr8:87520930 FAM82B -0.48 -7.02 -0.36 1.3e-11 Caudate activity during reward; CRC cis rs11971779 0.618 rs13068 chr7:139104141 G/C cg23387468 chr7:139079360 LUC7L2 0.41 7.05 0.36 1.04e-11 Diisocyanate-induced asthma; CRC cis rs17818399 0.547 rs35178974 chr2:46763898 T/C cg21681030 chr2:46777652 RHOQ 0.45 6.07 0.32 3.47e-9 Height; CRC cis rs17401966 0.898 rs12757288 chr1:10323921 T/C cg19773385 chr1:10388646 KIF1B -0.68 -11.18 -0.52 8.18e-25 Hepatocellular carcinoma; CRC cis rs2153535 0.580 rs4960412 chr6:8438261 G/C cg21535247 chr6:8435926 SLC35B3 0.48 7.26 0.37 2.78e-12 Motion sickness; CRC cis rs1223397 1.000 rs1223402 chr6:13271640 G/A cg21538684 chr6:13274180 PHACTR1 0.46 5.71 0.3 2.59e-8 Blood pressure; CRC cis rs2070488 0.965 rs9829192 chr3:38569463 G/T cg01465620 chr3:38496096 LOC100128640;ACVR2B -0.9 -16.62 -0.68 1.91e-45 Electrocardiographic conduction measures; CRC cis rs11690935 0.959 rs6433314 chr2:172660971 A/G cg13550731 chr2:172543902 DYNC1I2 -1.03 -17.09 -0.69 2.53e-47 Schizophrenia; CRC cis rs6546550 0.935 rs4853027 chr2:70039224 A/G cg02498382 chr2:70120550 SNRNP27 0.43 7.1 0.36 7.61e-12 Prevalent atrial fibrillation; CRC cis rs7811142 1.000 rs73405353 chr7:100091215 G/A cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.56 6.95 0.36 2e-11 Platelet count; CRC cis rs1506636 1.000 rs1506636 chr7:123317140 C/T cg03229431 chr7:123269106 ASB15 0.75 12.35 0.56 4.75e-29 Plateletcrit;Platelet count; CRC trans rs2303319 0.504 rs13417851 chr2:162559919 T/G cg18122310 chr12:50236657 BCDIN3D -0.68 -6.08 -0.32 3.35e-9 Cognitive function; CRC cis rs1218582 0.772 rs10796935 chr1:154891363 G/T cg06221963 chr1:154839813 KCNN3 -0.77 -15.56 -0.65 2.56e-41 Prostate cancer; CRC cis rs6691722 0.503 rs6667695 chr1:24707669 G/A cg02336364 chr1:24764700 NIPAL3 0.38 6.25 0.33 1.28e-9 Response to interferon beta in multiple sclerosis; CRC trans rs2797160 0.651 rs1268067 chr6:126036621 T/C cg05039488 chr6:79577232 IRAK1BP1 0.6 9.37 0.46 1.17e-18 Endometrial cancer; CRC cis rs1881797 0.872 rs2141544 chr1:247690800 A/G cg11166453 chr1:247681781 NA 0.47 8.59 0.43 3.48e-16 Acute lymphoblastic leukemia (childhood); CRC cis rs1050846 0.564 rs1050863 chr16:87440895 C/T cg27585878 chr16:87386489 FBXO31 -0.43 -6.96 -0.36 1.91e-11 Neuroticism; CRC cis rs6952808 0.723 rs11766575 chr7:2005747 T/C cg04267008 chr7:1944627 MAD1L1 -0.79 -11.48 -0.53 6.72e-26 Bipolar disorder and schizophrenia; CRC cis rs875971 0.830 rs4718358 chr7:65973668 T/C cg12463550 chr7:65579703 CRCP 0.49 7.01 0.36 1.39e-11 Aortic root size; CRC cis rs7786808 0.504 rs10949725 chr7:158196003 C/T cg17401720 chr7:158221031 PTPRN2 -0.42 -6.98 -0.36 1.68e-11 Obesity-related traits; CRC cis rs832540 0.656 rs6862118 chr5:56106474 G/A cg12311346 chr5:56204834 C5orf35 -0.5 -7.48 -0.38 6.65e-13 Coronary artery disease; CRC cis rs28386778 0.863 rs3826341 chr17:61819222 C/A cg06873352 chr17:61820015 STRADA 0.75 13.96 0.61 4.22e-35 Prudent dietary pattern; CRC cis rs7429990 1.000 rs1665982 chr3:47905079 A/G cg11946769 chr3:48343235 NME6 -0.54 -6.47 -0.34 3.55e-10 Educational attainment (years of education); CRC cis rs72945132 0.882 rs7128969 chr11:70205017 C/A cg00319359 chr11:70116639 PPFIA1 0.55 6.04 0.32 4.16e-9 Coronary artery disease; CRC cis rs6456156 0.528 rs6936261 chr6:167469676 A/C cg07741184 chr6:167504864 NA 0.38 6.79 0.35 5.28e-11 Primary biliary cholangitis; CRC trans rs9585327 0.584 rs4772260 chr13:100645723 A/G cg26868354 chr6:35699952 LOC285847 0.38 6.05 0.32 3.96e-9 Myopia; CRC cis rs6951245 0.745 rs79788515 chr7:1101079 C/T cg03188948 chr7:1209495 NA 0.65 6.77 0.35 5.76e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs28493229 0.708 rs10407889 chr19:41161078 T/C cg21869046 chr19:41225005 ITPKC 0.41 6.15 0.32 2.26e-9 Kawasaki disease; CRC cis rs736408 0.522 rs11130310 chr3:52674667 C/T cg15147215 chr3:52552868 STAB1 -0.64 -10.99 -0.52 3.72e-24 Bipolar disorder; CRC cis rs9311474 0.508 rs2878628 chr3:52584715 C/T cg10802521 chr3:52805072 NEK4 0.58 9.04 0.45 1.36e-17 Electroencephalogram traits; CRC cis rs17641971 0.684 rs1876717 chr8:49994968 T/G cg00325661 chr8:49890786 NA 0.37 6.29 0.33 1e-9 Blood metabolite levels; CRC trans rs113835537 0.627 rs4630309 chr11:66333072 A/C cg17774305 chr12:50505649 C12orf62 0.57 5.97 0.31 6.15e-9 Airway imaging phenotypes; CRC cis rs1865760 0.566 rs1800702 chr6:26086463 C/G cg17691542 chr6:26056736 HIST1H1C 0.56 8.51 0.42 6.1e-16 Height; CRC cis rs7246657 0.943 rs3745765 chr19:37854235 G/T cg23950597 chr19:37808831 NA -0.47 -5.76 -0.3 1.94e-8 Coronary artery calcification; CRC cis rs9326248 0.501 rs4938351 chr11:117022352 A/C cg10398005 chr11:117014888 PAFAH1B2 -0.45 -6.75 -0.35 6.83e-11 Blood protein levels; CRC cis rs7044106 0.648 rs2031369 chr9:123360294 G/A cg09419670 chr9:123605666 PSMD5;LOC253039 0.62 9.85 0.48 3.17e-20 Hip circumference adjusted for BMI; CRC cis rs6952808 0.723 rs4721282 chr7:2025040 A/G cg18279126 chr7:2041391 MAD1L1 0.43 6.5 0.34 2.93e-10 Bipolar disorder and schizophrenia; CRC cis rs4563143 0.675 rs56322221 chr19:29270349 A/T cg14983838 chr19:29218262 NA 0.48 6.95 0.36 1.93e-11 Methadone dose in opioid dependence; CRC cis rs931127 0.692 rs7934517 chr11:65445673 C/T cg27068330 chr11:65405492 SIPA1 -0.43 -5.95 -0.31 6.87e-9 Systemic lupus erythematosus; CRC cis rs2692947 0.644 rs2969491 chr2:96794982 C/T cg23100626 chr2:96804247 ASTL 0.32 8.72 0.43 1.36e-16 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; CRC cis rs763014 1.000 rs2269558 chr16:682250 C/T cg02475695 chr16:616220 NHLRC4 0.45 7.25 0.37 3.06e-12 Height; CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg17404403 chr4:110737017 GAR1 0.41 6.61 0.34 1.55e-10 Obesity-related traits; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg06745235 chr1:180471494 ACBD6 0.47 6.04 0.32 4.2e-9 Thyroid stimulating hormone; CRC cis rs7726839 0.507 rs72703100 chr5:614291 C/T cg17948913 chr5:572064 NA 0.51 5.91 0.31 8.58e-9 Obesity-related traits; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg11126068 chr11:67195806 RPS6KB2 0.5 6.41 0.33 5.03e-10 Thyroid stimulating hormone; CRC cis rs9549260 0.755 rs8001443 chr13:41216646 C/T cg21288729 chr13:41239152 FOXO1 -0.46 -7.22 -0.37 3.58e-12 Red blood cell count; CRC cis rs977987 0.778 rs4243112 chr16:75321031 T/C cg03315344 chr16:75512273 CHST6 0.54 8.95 0.44 2.61e-17 Dupuytren's disease; CRC cis rs1707322 0.721 rs12037803 chr1:46156492 A/G cg03146154 chr1:46216737 IPP 0.67 9.82 0.48 3.95e-20 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs9341808 0.727 rs1324120 chr6:80976125 G/C cg08355045 chr6:80787529 NA 0.39 6.39 0.33 5.64e-10 Sitting height ratio; CRC cis rs7772486 0.754 rs6932863 chr6:146021255 A/T cg13319975 chr6:146136371 FBXO30 0.45 6.72 0.35 8.23e-11 Lobe attachment (rater-scored or self-reported); CRC cis rs67478160 0.643 rs4900594 chr14:104251006 C/T cg01849466 chr14:104193079 ZFYVE21 -0.48 -8.31 -0.42 2.58e-15 Schizophrenia; CRC cis rs2404602 0.735 rs4886495 chr15:76738959 C/T cg23625390 chr15:77176239 SCAPER 0.85 14.04 0.61 2.06e-35 Blood metabolite levels; CRC cis rs17641971 0.708 rs10957317 chr8:49888870 C/T cg00325661 chr8:49890786 NA -0.35 -6.13 -0.32 2.47e-9 Blood metabolite levels; CRC cis rs9486715 1.000 rs9386670 chr6:97060688 C/A cg06623918 chr6:96969491 KIAA0776 -0.97 -17.06 -0.69 3.26e-47 Headache; CRC cis rs11252926 0.565 rs60553947 chr10:474284 T/C cg18196295 chr10:418757 DIP2C -0.55 -8.21 -0.41 5.06e-15 Psychosis in Alzheimer's disease; CRC cis rs8031584 0.958 rs8034856 chr15:31240957 T/C cg14829155 chr15:31115871 NA -0.51 -8.12 -0.41 9.61e-15 Huntington's disease progression; CRC cis rs12541635 1.000 rs7817197 chr8:107089633 T/G cg10147462 chr8:107024639 NA -0.37 -6.3 -0.33 9.62e-10 Age of smoking initiation; CRC cis rs4253772 0.591 rs6008362 chr22:46652737 G/A cg03482458 chr22:46692211 CN5H6.4;GTSE1 0.49 6.53 0.34 2.44e-10 LDL cholesterol;Cholesterol, total; CRC cis rs7772486 0.764 rs7762562 chr6:146158994 T/C cg23711669 chr6:146136114 FBXO30 0.73 12.56 0.57 8.05e-30 Lobe attachment (rater-scored or self-reported); CRC cis rs294883 0.739 rs1847482 chr6:159731324 A/C cg14500486 chr6:159655392 FNDC1 -0.36 -6.27 -0.33 1.14e-9 Coronary artery disease; CRC cis rs2404602 0.503 rs284909 chr15:76736628 C/T cg03037974 chr15:76606532 NA 0.59 9.98 0.48 1.18e-20 Blood metabolite levels; CRC cis rs9296095 0.607 rs9366824 chr6:33521577 C/T cg14003231 chr6:33640908 ITPR3 0.46 7.07 0.36 9.49e-12 Platelet count; CRC trans rs7395662 0.929 rs10838934 chr11:48547072 G/A cg21153622 chr11:89784906 NA -0.48 -7.64 -0.39 2.36e-13 HDL cholesterol; CRC cis rs938554 0.806 rs4447862 chr4:9931645 C/G cg00071950 chr4:10020882 SLC2A9 -0.39 -5.72 -0.3 2.38e-8 Blood metabolite levels; CRC cis rs3106136 0.527 rs2883 chr4:95158610 A/T cg11021082 chr4:95130006 SMARCAD1 -0.6 -9.52 -0.46 4e-19 Capecitabine sensitivity; CRC cis rs4713118 0.699 rs200978 chr6:27853168 C/G cg10876282 chr6:28092338 ZSCAN16 0.47 5.72 0.3 2.36e-8 Parkinson's disease; CRC trans rs57221529 0.766 rs72703070 chr5:590458 T/C cg11887960 chr12:57824829 NA 0.63 6.95 0.36 1.94e-11 Lung disease severity in cystic fibrosis; CRC cis rs2333194 0.875 rs28716532 chr14:73769255 T/C cg19682024 chr14:74008259 HEATR4;ACOT1 -0.42 -6.36 -0.33 6.74e-10 Bipolar disorder with mood-incongruent psychosis; CRC cis rs1865760 0.516 rs9379818 chr6:26023206 G/T cg17691542 chr6:26056736 HIST1H1C 0.54 8.4 0.42 1.39e-15 Height; CRC cis rs2011503 0.882 rs751857 chr19:19602873 G/T cg11584989 chr19:19387371 SF4 0.56 6.35 0.33 7.35e-10 Bipolar disorder; CRC trans rs561341 0.941 rs2428336 chr17:30290577 T/C cg27661571 chr11:113659931 NA -0.81 -10.15 -0.49 3.12e-21 Hip circumference adjusted for BMI; CRC cis rs34172651 0.583 rs200541 chr16:24733141 A/G cg06028605 chr16:24865363 SLC5A11 -0.54 -8.37 -0.42 1.7e-15 Intelligence (multi-trait analysis); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg14685339 chr14:77787351 POMT2;GSTZ1 0.45 6.45 0.34 4.05e-10 Response to antipsychotic treatment; CRC cis rs933688 1.000 rs6452953 chr5:90723034 T/G cg26981201 chr5:90679533 LOC100129716;ARRDC3 1.02 18.19 0.71 1.14e-51 Smoking behavior; CRC trans rs1455244 0.700 rs7229302 chr18:11508904 G/T cg04799218 chr12:7125780 LPCAT3 0.43 6.67 0.35 1.07e-10 Schizophrenia; CRC cis rs12580194 0.556 rs61249728 chr12:55728922 A/G cg19537932 chr12:55886519 OR6C68 -0.64 -8.39 -0.42 1.46e-15 Cancer; CRC cis rs72781680 0.898 rs72790310 chr2:24116716 C/T cg08917208 chr2:24149416 ATAD2B 0.87 8.59 0.43 3.46e-16 Lymphocyte counts; CRC cis rs11212617 0.967 rs4754324 chr11:108325448 G/A cg12106634 chr11:108092400 ATM;NPAT 0.39 5.67 0.3 3.17e-8 Response to metformin in type 2 diabetes (glycemic); CRC cis rs2050392 1.000 rs2489864 chr10:30693744 C/G cg25182066 chr10:30743637 MAP3K8 -0.39 -5.72 -0.3 2.44e-8 Inflammatory bowel disease; CRC cis rs12594515 1.000 rs8033148 chr15:45997929 G/A cg01629716 chr15:45996671 NA 0.41 8.34 0.42 2.13e-15 Waist circumference;Weight; CRC cis rs28386778 0.897 rs2584626 chr17:61903179 A/G cg07362569 chr17:61921086 SMARCD2 0.38 5.95 0.31 6.87e-9 Prudent dietary pattern; CRC cis rs6461049 0.766 rs10256077 chr7:2171450 C/T cg21782813 chr7:2030301 MAD1L1 -0.45 -8.36 -0.42 1.78e-15 Schizophrenia; CRC cis rs6690583 0.697 rs10782537 chr1:85484473 C/T cg02621376 chr1:85461303 MCOLN2 -0.41 -6.0 -0.31 5.19e-9 Serum sulfate level; CRC cis rs889312 0.500 rs252920 chr5:56148741 C/A cg03609598 chr5:56110824 MAP3K1 -0.42 -5.76 -0.3 1.91e-8 Breast cancer;Breast cancer (early onset); CRC cis rs523522 0.962 rs4767905 chr12:120930835 C/T cg27279351 chr12:120934652 DYNLL1 0.79 11.6 0.54 2.58e-26 High light scatter reticulocyte count; CRC cis rs6952808 0.656 rs73048919 chr7:2103637 C/A cg21782813 chr7:2030301 MAD1L1 0.55 9.31 0.46 1.83e-18 Bipolar disorder and schizophrenia; CRC cis rs6951245 0.572 rs75083636 chr7:1050800 C/T cg24642844 chr7:1081250 C7orf50 -0.92 -7.8 -0.4 8.12e-14 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs1568889 0.838 rs11030229 chr11:28173634 T/C cg06544937 chr11:28130018 METT5D1;KIF18A 0.91 15.14 0.64 1.12e-39 Bipolar disorder; CRC cis rs28386778 0.897 rs2584617 chr17:61925298 C/T cg11494091 chr17:61959527 GH2 0.6 10.28 0.49 1.07e-21 Prudent dietary pattern; CRC cis rs7705042 0.865 rs413214 chr5:141530157 G/A cg07392085 chr5:141489673 NDFIP1 0.46 7.35 0.38 1.6e-12 Asthma; CRC cis rs4731207 0.662 rs35630355 chr7:124549333 T/A cg23710748 chr7:124431027 NA -0.37 -5.98 -0.31 5.75e-9 Cutaneous malignant melanoma; CRC trans rs7553035 0.850 rs7355220 chr1:211690029 T/C cg04286297 chr15:83655119 FAM103A1 -0.66 -6.04 -0.32 4.08e-9 Retinopathy in non-diabetics; CRC cis rs9611565 0.681 rs132918 chr22:41808350 C/T cg03806693 chr22:41940476 POLR3H 0.99 12.64 0.57 3.87e-30 Vitiligo; CRC trans rs61931739 0.500 rs11053261 chr12:34530810 C/T cg26384229 chr12:38710491 ALG10B 0.68 8.8 0.44 7.69e-17 Morning vs. evening chronotype; CRC cis rs10486722 0.624 rs10155874 chr7:41765719 A/G cg22138096 chr7:41772439 LOC285954 0.39 5.81 0.31 1.47e-8 Pit-and-Fissure caries; CRC trans rs1814175 0.645 rs1721997 chr11:49916653 T/C cg11707556 chr5:10655725 ANKRD33B -0.52 -9.95 -0.48 1.49e-20 Height; CRC cis rs4363385 0.626 rs11205179 chr1:153021399 A/G cg25856811 chr1:152973957 SPRR3 -0.24 -6.62 -0.34 1.46e-10 Inflammatory skin disease; CRC cis rs9354308 0.966 rs1909533 chr6:66565658 G/A cg07460842 chr6:66804631 NA 0.47 5.85 0.31 1.17e-8 Metabolite levels; CRC cis rs28386778 0.799 rs12450683 chr17:61984299 C/G cg11494091 chr17:61959527 GH2 0.73 14.67 0.63 7.41e-38 Prudent dietary pattern; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg05774672 chr2:208631916 FZD5 0.33 6.08 0.32 3.37e-9 Liver disease severity in Alagille syndrome; CRC trans rs2976388 0.609 rs1560986 chr8:143789775 T/C cg24628676 chr5:59189846 PDE4D -0.3 -6.08 -0.32 3.3e-9 Urinary tract infection frequency; CRC cis rs7781266 0.790 rs73148993 chr7:133178410 C/A cg03336402 chr7:133662267 EXOC4 0.48 5.71 0.3 2.57e-8 Educational attainment (college completion); CRC cis rs11098499 0.779 rs28495013 chr4:120375831 A/C cg09307838 chr4:120376055 NA 0.72 11.14 0.52 1.1e-24 Corneal astigmatism; CRC cis rs6502050 0.835 rs35131307 chr17:80128439 G/A cg19223190 chr17:80058835 NA 0.38 6.02 0.32 4.64e-9 Life satisfaction; CRC cis rs10911251 0.546 rs944971 chr1:183112505 T/C ch.1.3577855R chr1:183094577 LAMC1 0.83 14.65 0.63 9.3e-38 Colorectal cancer; CRC cis rs12474201 0.928 rs1109380 chr2:46924490 G/T cg06386533 chr2:46925753 SOCS5 0.8 13.23 0.59 2.51e-32 Height; CRC cis rs12913538 0.926 rs12438162 chr15:62884463 A/G cg09983546 chr15:62884068 NA 0.52 7.99 0.4 2.33e-14 Sleep depth; CRC cis rs873946 0.564 rs35831787 chr10:134546346 T/C cg06453172 chr10:134556979 INPP5A -0.65 -8.65 -0.43 2.28e-16 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CRC trans rs6550704 0.687 rs9865314 chr3:22634337 A/G cg03311606 chr2:173292277 ITGA6 -0.42 -6.08 -0.32 3.32e-9 Daytime sleep phenotypes; CRC cis rs501120 0.584 rs966161 chr10:44712574 C/T cg09554077 chr10:44749378 NA 0.65 7.29 0.37 2.37e-12 Coronary artery disease;Coronary heart disease; CRC trans rs2303319 0.504 rs62188960 chr2:162492578 A/C cg22988483 chr14:93581567 ITPK1 -0.67 -6.04 -0.32 4.16e-9 Cognitive function; CRC cis rs9325144 0.650 rs6582624 chr12:38733475 A/T cg13010199 chr12:38710504 ALG10B -0.43 -5.9 -0.31 8.97e-9 Morning vs. evening chronotype; CRC cis rs7772486 0.754 rs13214277 chr6:146136125 G/T cg23711669 chr6:146136114 FBXO30 0.78 13.58 0.6 1.16e-33 Lobe attachment (rater-scored or self-reported); CRC cis rs4665809 0.590 rs1368902 chr2:26440576 T/C cg22920501 chr2:26401640 FAM59B -0.83 -11.96 -0.55 1.28e-27 Gut microbiome composition (summer); CRC cis rs72772090 0.634 rs12186366 chr5:96088850 A/G cg17330273 chr5:96107758 CAST;ERAP1 -0.68 -6.55 -0.34 2.22e-10 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs2197308 0.765 rs2387436 chr12:37935337 C/T cg26384229 chr12:38710491 ALG10B -0.63 -9.53 -0.47 3.49e-19 Morning vs. evening chronotype; CRC cis rs10504229 1.000 rs17216620 chr8:58169412 A/G cg05313129 chr8:58192883 C8orf71 -0.48 -7.23 -0.37 3.38e-12 Developmental language disorder (linguistic errors); CRC cis rs1552244 1.000 rs12152512 chr3:10143770 C/T cg16606324 chr3:10149918 C3orf24 0.69 9.76 0.47 6.24e-20 Alzheimer's disease; CRC cis rs769267 0.899 rs3934667 chr19:19431423 T/G cg01262667 chr19:19385393 TM6SF2 -0.37 -6.17 -0.32 2.05e-9 Tonsillectomy; CRC cis rs1609391 0.543 rs9828009 chr3:136631275 C/T cg15507776 chr3:136538369 TMEM22 0.34 6.19 0.32 1.83e-9 Neuroticism; CRC cis rs11098499 0.821 rs10032151 chr4:120391628 C/T cg24375607 chr4:120327624 NA 0.5 7.72 0.39 1.39e-13 Corneal astigmatism; CRC cis rs780096 0.526 rs2010087 chr2:27637235 C/T cg24768116 chr2:27665128 KRTCAP3 -0.35 -7.75 -0.39 1.18e-13 Total body bone mineral density; CRC trans rs208520 0.690 rs12202401 chr6:66760544 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 1.04 14.58 0.63 1.78e-37 Exhaled nitric oxide output; CRC trans rs3942852 0.568 rs6485807 chr11:48102867 G/A cg03929089 chr4:120376271 NA -0.6 -8.41 -0.42 1.29e-15 Acute lymphoblastic leukemia (childhood); CRC trans rs925098 0.577 rs2724470 chr4:17996046 A/G cg26197690 chr5:139936946 SRA1 -0.42 -5.99 -0.31 5.61e-9 Birth weight;Height; CRC cis rs7193541 0.684 rs7201320 chr16:74694058 T/G cg01733217 chr16:74700730 RFWD3 1.06 22.02 0.77 1.08e-66 Multiple myeloma; CRC cis rs7824557 0.583 rs6601585 chr8:11233659 A/G cg08071915 chr8:12219732 FAM66A 0.35 6.26 0.33 1.23e-9 Retinal vascular caliber; CRC cis rs1153858 1.000 rs12437840 chr15:45669055 C/A cg21132104 chr15:45694354 SPATA5L1 0.57 8.24 0.41 4.06e-15 Homoarginine levels; CRC cis rs2070488 0.775 rs1073506 chr3:38566235 G/T cg01465620 chr3:38496096 LOC100128640;ACVR2B -0.72 -11.98 -0.55 1.12e-27 Electrocardiographic conduction measures; CRC cis rs8070463 0.515 rs11655943 chr17:45385640 A/G cg08085267 chr17:45401833 C17orf57 -0.74 -13.17 -0.59 4.24e-32 Multiple sclerosis;Ankylosing spondylitis; CRC trans rs2303319 0.504 rs66761688 chr2:162578911 T/C cg01422129 chr2:677375 TMEM18 -0.72 -6.01 -0.31 4.92e-9 Cognitive function; CRC cis rs4072980 0.545 rs16824518 chr1:38415315 A/C cg12658694 chr1:38397304 INPP5B -0.53 -7.54 -0.38 4.48e-13 Coronary artery disease; CRC cis rs10504229 0.683 rs6999984 chr8:58115079 G/A cg05313129 chr8:58192883 C8orf71 -0.43 -6.05 -0.32 4.04e-9 Developmental language disorder (linguistic errors); CRC cis rs6502050 0.799 rs4132775 chr17:80155412 C/T cg19223190 chr17:80058835 NA 0.4 6.4 0.33 5.26e-10 Life satisfaction; CRC cis rs9304742 0.683 rs10402714 chr19:53463680 G/A cg09915433 chr19:53449742 NA -0.49 -7.0 -0.36 1.44e-11 Psoriasis; CRC trans rs10983614 1.000 rs7867776 chr9:120072627 A/G cg03468541 chr14:89029199 ZC3H14 0.46 6.48 0.34 3.43e-10 Survival in pancreatic cancer; CRC cis rs4332037 0.906 rs62442903 chr7:1953416 G/A cg24505167 chr7:1915268 MAD1L1 -0.41 -5.63 -0.3 3.88e-8 Bipolar disorder; CRC cis rs12760731 0.565 rs12048698 chr1:178136792 T/C cg00404053 chr1:178313656 RASAL2 1.1 11.39 0.53 1.43e-25 Obesity-related traits; CRC cis rs9311474 0.508 rs6788887 chr3:52605005 T/C cg10802521 chr3:52805072 NEK4 -0.56 -8.89 -0.44 4e-17 Electroencephalogram traits; CRC cis rs6860806 0.507 rs272854 chr5:131688017 C/T cg04518342 chr5:131593106 PDLIM4 0.43 7.08 0.36 8.99e-12 Breast cancer; CRC cis rs8177253 0.665 rs12639304 chr3:133441594 A/T cg11941060 chr3:133502564 NA -0.42 -6.87 -0.35 3.25e-11 Iron status biomarkers; CRC cis rs6918586 0.594 rs198842 chr6:26111448 C/T cg18357526 chr6:26021779 HIST1H4A -0.49 -7.4 -0.38 1.16e-12 Schizophrenia; CRC cis rs10791097 0.609 rs3751039 chr11:130773076 A/G cg12179176 chr11:130786555 SNX19 -0.8 -14.01 -0.61 2.61e-35 Autism spectrum disorder or schizophrenia;Schizophrenia; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg14022530 chr1:100598534 SASS6;CCDC76 0.4 6.01 0.31 5.01e-9 Intelligence (multi-trait analysis); CRC cis rs853679 0.517 rs9380049 chr6:28048535 A/G cg12963246 chr6:28129442 ZNF389 0.47 5.61 0.3 4.26e-8 Depression; CRC cis rs362272 0.524 rs3129334 chr4:3368526 T/C cg11522145 chr4:3412961 RGS12 -0.42 -6.43 -0.33 4.38e-10 Serum sulfate level; CRC cis rs17209837 1.000 rs45502492 chr7:87089898 C/T cg00919237 chr7:87102261 ABCB4 -0.47 -5.63 -0.3 3.84e-8 Gallbladder cancer; CRC cis rs877282 1.000 rs112522746 chr10:772288 T/C cg17470449 chr10:769945 NA 0.6 8.43 0.42 1.1e-15 Uric acid levels; CRC cis rs736408 0.716 rs2239550 chr3:52822509 G/C cg18404041 chr3:52824283 ITIH1 -0.5 -10.38 -0.5 5.21e-22 Bipolar disorder; CRC cis rs10540 1.000 rs35231079 chr11:515224 G/A cg03934478 chr11:495069 RNH1 0.7 7.84 0.4 6.44e-14 Body mass index; CRC cis rs6951245 1.000 rs11763793 chr7:1094342 A/G cg20603222 chr7:1096387 C7orf50;GPR146 -0.73 -8.76 -0.44 1.02e-16 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs1023500 0.596 rs133369 chr22:42463814 C/T cg11915388 chr22:42470451 FAM109B -0.43 -6.54 -0.34 2.3e-10 Schizophrenia; CRC cis rs28386778 0.897 rs2137144 chr17:61805607 G/A cg22520471 chr17:61851767 DDX42;CCDC47 0.72 11.02 0.52 3.01e-24 Prudent dietary pattern; CRC cis rs727563 0.638 rs5996058 chr22:42141452 A/G cg03806693 chr22:41940476 POLR3H 1.08 13.48 0.6 2.85e-33 Crohn's disease;Inflammatory bowel disease; CRC cis rs2836974 0.899 rs2836957 chr21:40623134 T/C cg11644478 chr21:40555479 PSMG1 0.81 12.35 0.56 4.95e-29 Cognitive function; CRC cis rs1218582 0.772 rs6699043 chr1:154913021 T/C cg03351412 chr1:154909251 PMVK 0.53 8.43 0.42 1.07e-15 Prostate cancer; CRC cis rs7586879 0.789 rs13404163 chr2:25126616 A/G cg04586622 chr2:25135609 ADCY3 -0.57 -9.53 -0.46 3.71e-19 Body mass index; CRC cis rs40363 0.645 rs250629 chr16:3525431 C/A cg00484396 chr16:3507460 NAT15 0.53 7.92 0.4 3.8e-14 Tuberculosis; CRC cis rs995000 0.868 rs1168114 chr1:63156043 C/T cg19896129 chr1:63156450 NA 0.44 6.82 0.35 4.25e-11 Triglyceride levels; CRC cis rs597539 0.615 rs629426 chr11:68671104 A/G cg04772025 chr11:68637568 NA 0.49 7.58 0.39 3.65e-13 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs875971 1.000 rs2420168 chr7:65630631 C/G cg11764359 chr7:65958608 NA -0.61 -9.86 -0.48 2.98e-20 Aortic root size; CRC cis rs1355223 1.000 rs11601923 chr11:34764354 C/G cg11058730 chr11:34937778 PDHX;APIP -0.45 -6.38 -0.33 5.97e-10 Systemic lupus erythematosus and Systemic sclerosis; CRC cis rs3857067 1.000 rs2199603 chr4:95016174 G/A cg11021082 chr4:95130006 SMARCAD1 -0.4 -6.05 -0.32 3.9e-9 QT interval; CRC trans rs60843830 1.000 rs7595075 chr2:264019 C/A cg11347411 chr7:150020925 ACTR3C;LRRC61 0.59 9.21 0.45 3.84e-18 Spherical equivalent (joint analysis main effects and education interaction); CRC cis rs9467711 0.591 rs9461223 chr6:25918335 T/C cg08501292 chr6:25962987 TRIM38 0.98 9.41 0.46 8.79e-19 Autism spectrum disorder or schizophrenia; CRC cis rs7618915 0.547 rs6976 chr3:52728804 C/T cg15147215 chr3:52552868 STAB1 -0.61 -9.78 -0.47 5.21e-20 Bipolar disorder; CRC cis rs2303759 0.874 rs8108669 chr19:49845895 C/T cg22133161 chr19:49891603 CCDC155 0.52 7.28 0.37 2.41e-12 Multiple sclerosis; CRC cis rs977987 0.778 rs11149825 chr16:75434878 C/T cg03315344 chr16:75512273 CHST6 0.54 9.09 0.45 9.82e-18 Dupuytren's disease; CRC trans rs11098499 0.863 rs1010740 chr4:120463409 C/T cg25214090 chr10:38739885 LOC399744 -0.65 -10.4 -0.5 4.42e-22 Corneal astigmatism; CRC cis rs6694672 0.850 rs1953064 chr1:197064826 A/G cg13682187 chr1:196946512 CFHR5 0.43 6.97 0.36 1.74e-11 Asthma; CRC cis rs738322 0.935 rs133014 chr22:38571087 T/G cg17652424 chr22:38574118 PLA2G6 -0.22 -6.73 -0.35 7.71e-11 Cutaneous nevi; CRC cis rs514406 0.505 rs431459 chr1:53183230 T/G cg27535305 chr1:53392650 SCP2 -0.33 -5.77 -0.3 1.84e-8 Monocyte count; CRC trans rs11098499 0.821 rs3775852 chr4:120454556 A/G cg25214090 chr10:38739885 LOC399744 0.65 10.07 0.49 5.96e-21 Corneal astigmatism; CRC trans rs61931739 0.500 rs6488215 chr12:34434803 A/T cg26384229 chr12:38710491 ALG10B 0.61 8.99 0.44 2.05e-17 Morning vs. evening chronotype; CRC cis rs72634258 0.945 rs34466510 chr1:8147412 T/C cg26816564 chr1:7831052 VAMP3 0.57 6.07 0.32 3.61e-9 Inflammatory bowel disease; CRC cis rs35146811 0.660 rs3779045 chr7:99779259 T/C cg13334819 chr7:99746414 C7orf59 -0.51 -6.72 -0.35 7.79e-11 Coronary artery disease; CRC trans rs875971 0.545 rs4718325 chr7:65680310 G/A cg02869306 chr7:64672164 INTS4L1 -0.43 -6.15 -0.32 2.28e-9 Aortic root size; CRC cis rs10791323 0.569 rs2298738 chr11:133715153 G/C cg15485101 chr11:133734466 NA 0.41 6.83 0.35 3.99e-11 Childhood ear infection; CRC cis rs2404602 0.967 rs12148805 chr15:76800659 G/A cg23625390 chr15:77176239 SCAPER 0.61 9.56 0.47 2.83e-19 Blood metabolite levels; CRC cis rs1799949 1.000 rs8176318 chr17:41197274 G/T cg23758822 chr17:41437982 NA 0.76 12.91 0.58 4.08e-31 Menopause (age at onset); CRC cis rs26868 0.766 rs30995 chr16:2248017 C/T cg07587117 chr16:2239488 CASKIN1 -0.4 -7.17 -0.37 4.98e-12 Height; CRC trans rs11250098 0.547 rs2409764 chr8:11281273 C/T cg06636001 chr8:8085503 FLJ10661 0.43 6.21 0.32 1.64e-9 Morning vs. evening chronotype; CRC cis rs10504229 0.906 rs903718 chr8:58167726 A/G cg02290350 chr8:58132656 NA -0.44 -6.96 -0.36 1.82e-11 Developmental language disorder (linguistic errors); CRC cis rs9916302 0.706 rs11078894 chr17:37396805 C/G cg00129232 chr17:37814104 STARD3 -0.58 -7.2 -0.37 4.02e-12 Glomerular filtration rate (creatinine); CRC cis rs611744 0.647 rs13280487 chr8:109270263 G/C cg21045802 chr8:109455806 TTC35 0.42 6.7 0.35 9.11e-11 Dupuytren's disease; CRC cis rs9303401 0.614 rs2333409 chr17:57139134 G/A cg02118635 chr17:56770003 RAD51C;TEX14 0.67 8.37 0.42 1.68e-15 Cognitive test performance; CRC cis rs8060686 0.641 rs73612222 chr16:68216072 A/G cg26727032 chr16:67993705 SLC12A4 -0.54 -6.61 -0.34 1.56e-10 HDL cholesterol;Metabolic syndrome; CRC cis rs2032447 0.765 rs6942072 chr6:26014987 A/G cg12310025 chr6:25882481 NA -0.49 -6.98 -0.36 1.62e-11 Intelligence (multi-trait analysis); CRC cis rs11098499 0.954 rs11098525 chr4:120390152 G/A cg24375607 chr4:120327624 NA 0.49 7.6 0.39 3.1400000000000003e-13 Corneal astigmatism; CRC cis rs826838 1.000 rs826891 chr12:39100824 A/G cg26384229 chr12:38710491 ALG10B -0.61 -9.61 -0.47 1.92e-19 Heart rate; CRC cis rs8060686 0.591 rs255054 chr16:68017356 A/G cg26727032 chr16:67993705 SLC12A4 -0.51 -5.68 -0.3 2.9e-8 HDL cholesterol;Metabolic syndrome; CRC cis rs9463078 0.526 rs9472337 chr6:44711576 C/A cg25276700 chr6:44698697 NA 0.31 7.79 0.39 8.87e-14 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; CRC cis rs7098414 0.511 rs7071752 chr10:82159539 C/A cg00277334 chr10:82204260 NA -0.5 -8.16 -0.41 6.96e-15 Post bronchodilator FEV1; CRC cis rs2120019 0.938 rs5020842 chr15:75322310 T/C cg09165964 chr15:75287851 SCAMP5 -0.86 -13.45 -0.6 3.8e-33 Blood trace element (Zn levels); CRC cis rs10788264 0.504 rs10749451 chr10:124028040 C/T cg09507567 chr10:124027408 NA 0.36 7.65 0.39 2.24e-13 Total body bone mineral density; CRC cis rs1003719 0.708 rs8126491 chr21:38551219 T/C cg10648535 chr21:38446584 PIGP;TTC3 -0.48 -6.72 -0.35 7.91e-11 Eye color traits; CRC cis rs6502050 0.835 rs10163485 chr17:80110750 C/T cg11859384 chr17:80120422 CCDC57 -0.37 -5.85 -0.31 1.16e-8 Life satisfaction; CRC cis rs12024301 0.557 rs11808304 chr1:183604095 A/T cg11505048 chr1:183622726 RGL1;APOBEC4 0.75 6.81 0.35 4.6e-11 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs10197940 0.510 rs7602715 chr2:152421937 A/G cg19508488 chr2:152266495 RIF1 0.47 6.5 0.34 2.94e-10 Lung cancer; CRC cis rs853679 0.550 rs1225598 chr6:28160799 T/G cg12273811 chr6:28175739 NA 0.76 10.93 0.52 6.19e-24 Depression; CRC cis rs9527 0.590 rs34104646 chr10:104896078 T/A cg04362960 chr10:104952993 NT5C2 0.6 8.32 0.42 2.32e-15 Arsenic metabolism; CRC cis rs6456156 0.742 rs1331299 chr6:167533467 A/G cg19688584 chr6:167529678 CCR6 0.36 6.7 0.35 9.07e-11 Primary biliary cholangitis; CRC cis rs873946 0.586 rs3793682 chr10:134564563 C/T cg18305652 chr10:134549665 INPP5A 0.49 6.26 0.33 1.23e-9 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CRC cis rs514406 0.861 rs503296 chr1:53283088 A/G cg25767906 chr1:53392781 SCP2 0.47 7.49 0.38 6.24e-13 Monocyte count; CRC cis rs4713118 0.869 rs9461401 chr6:27703291 G/A cg08798685 chr6:27730294 NA -0.42 -6.26 -0.33 1.23e-9 Parkinson's disease; CRC cis rs12541635 0.677 rs1429681 chr8:107048808 A/C cg10147462 chr8:107024639 NA 0.62 11.08 0.52 1.82e-24 Age of smoking initiation; CRC cis rs7309 0.935 rs6432674 chr2:162025322 G/T cg21518248 chr2:162101506 NA 0.45 6.64 0.34 1.29e-10 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Educational attainment; CRC cis rs7224737 1.000 rs9915255 chr17:40284191 C/T cg02228675 chr17:40259724 DHX58 -0.49 -6.87 -0.35 3.28e-11 Fibrinogen levels; CRC cis rs9649213 0.593 rs6465672 chr7:97963717 C/T cg00277769 chr7:97922759 BAIAP2L1 0.6 10.67 0.51 5.07e-23 Prostate cancer (SNP x SNP interaction); CRC cis rs10857712 0.754 rs2297031 chr10:135232654 C/T cg17796960 chr10:135278976 LOC619207 -0.39 -5.95 -0.31 6.85e-9 Systemic lupus erythematosus; CRC cis rs651907 0.535 rs61396602 chr3:101509046 T/C cg12386194 chr3:101231763 SENP7 0.52 7.54 0.38 4.53e-13 Colorectal cancer; CRC cis rs3733346 0.529 rs6842493 chr4:914638 T/C cg20814179 chr4:940893 TMEM175 0.58 10.55 0.5 1.35e-22 Sjögren's syndrome; CRC cis rs7178572 0.568 rs1493700 chr15:77629060 T/C cg22256960 chr15:77711686 NA -0.66 -9.58 -0.47 2.47e-19 Type 2 diabetes; CRC cis rs798554 0.797 rs798491 chr7:2800521 A/G cg04166393 chr7:2884313 GNA12 0.52 6.73 0.35 7.38e-11 Height; CRC cis rs9660992 0.573 rs4400674 chr1:205218425 A/C cg03948781 chr1:205179583 DSTYK -0.42 -5.72 -0.3 2.34e-8 Mean corpuscular volume;Mean platelet volume; CRC cis rs8010715 0.816 rs7153156 chr14:24598846 A/G cg23112188 chr14:24563095 PCK2 -0.37 -7.24 -0.37 3.17e-12 IgG glycosylation; CRC cis rs7945718 0.621 rs6485989 chr11:12695171 C/T cg25843174 chr11:12811716 TEAD1 0.39 7.05 0.36 1.04e-11 Educational attainment (years of education); CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg00320862 chr3:170588302 RPL22L1 -0.42 -6.33 -0.33 8.1e-10 Myopia (pathological); CRC cis rs2404602 0.536 rs7163946 chr15:76766049 C/G cg03037974 chr15:76606532 NA 0.66 11.61 0.54 2.33e-26 Blood metabolite levels; CRC cis rs992157 1.000 rs4674280 chr2:219141458 C/G cg13835894 chr2:219148914 PNKD;TMBIM1 -0.29 -5.62 -0.3 4.11e-8 Colorectal cancer; CRC cis rs13191362 0.507 rs13210000 chr6:163176944 G/A cg21926612 chr6:163149169 PACRG;PARK2 0.52 8.53 0.43 5.62e-16 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC trans rs4263408 0.934 rs9683743 chr4:39703194 A/C cg27239144 chr12:100661541 SCYL2;DEPDC4 -0.38 -5.97 -0.31 6.04e-9 Plasma amyloid beta peptide concentrations (ABx-40); CRC cis rs2976388 0.609 rs2585150 chr8:143792669 C/T cg20041105 chr8:143859282 LYNX1 0.46 8.24 0.41 4.25e-15 Urinary tract infection frequency; CRC cis rs4665809 1.000 rs4233708 chr2:26291345 C/T cg04944784 chr2:26401820 FAM59B -0.59 -7.58 -0.39 3.46e-13 Gut microbiome composition (summer); CRC cis rs950169 0.840 rs62029595 chr15:84955301 C/T cg11189052 chr15:85197271 WDR73 0.63 8.88 0.44 4.42e-17 Schizophrenia; CRC cis rs4927850 1.000 rs7627868 chr3:195753473 A/T cg00031303 chr3:195681400 NA 0.51 7.32 0.37 1.88e-12 Pancreatic cancer; CRC cis rs6502050 0.761 rs62078754 chr17:80058666 C/T cg13198984 chr17:80129470 CCDC57 -0.43 -7.09 -0.36 8.2e-12 Life satisfaction; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg10367730 chr10:120938495 PRDX3 0.43 6.21 0.32 1.63e-9 Intelligence (multi-trait analysis); CRC cis rs6586163 0.872 rs7914490 chr10:90747447 A/G cg13456138 chr10:90753195 FAS -0.43 -6.53 -0.34 2.57e-10 Chronic lymphocytic leukemia; CRC cis rs3741151 0.686 rs12276892 chr11:73283990 A/T cg17517138 chr11:73019481 ARHGEF17 0.54 5.78 0.3 1.75e-8 GIP levels in response to oral glucose tolerance test (120 minutes); CRC cis rs4843747 0.671 rs72818540 chr16:88078988 C/T cg17633681 chr16:88106987 BANP 0.8 13.64 0.6 6.88e-34 Menopause (age at onset); CRC cis rs4919694 0.611 rs76695159 chr10:105070837 C/T cg04362960 chr10:104952993 NT5C2 0.8 7.63 0.39 2.6e-13 Arsenic metabolism; CRC cis rs59104589 0.570 rs73006397 chr2:242415523 C/T cg19488206 chr2:242435732 STK25 0.47 7.44 0.38 8.73e-13 Fibrinogen levels; CRC cis rs490234 0.719 rs13287525 chr9:128219180 T/C cg14078157 chr9:128172775 NA -0.35 -5.74 -0.3 2.19e-8 Mean arterial pressure; CRC cis rs7100689 0.784 rs3802638 chr10:82179689 T/C cg00277334 chr10:82204260 NA -0.45 -5.92 -0.31 7.95e-9 Post bronchodilator FEV1; CRC cis rs6089584 0.888 rs2146853 chr20:60617908 A/T cg23463467 chr20:60627584 TAF4 0.33 5.71 0.3 2.53e-8 Body mass index; CRC cis rs2839186 0.770 rs2280956 chr21:47642323 C/G cg26721908 chr21:47610096 LSS 0.41 6.47 0.34 3.65e-10 Testicular germ cell tumor; CRC cis rs6598955 0.724 rs7526545 chr1:26569990 C/A cg00852783 chr1:26633632 UBXN11 0.43 6.97 0.36 1.73e-11 Obesity-related traits; CRC cis rs35306767 0.855 rs61830931 chr10:932497 T/C cg20503657 chr10:835505 NA 1.22 14.71 0.63 5.29e-38 Eosinophil percentage of granulocytes; CRC cis rs55794721 0.509 rs4649085 chr1:25778832 G/A cg20684491 chr1:25596433 NA 0.45 7.96 0.4 2.75e-14 Plateletcrit;Mean corpuscular volume; CRC cis rs7215564 0.908 rs2340772 chr17:78752017 C/A cg09596252 chr17:78655493 RPTOR -0.58 -6.07 -0.32 3.43e-9 Myopia (pathological); CRC cis rs75804782 0.641 rs55740938 chr2:239332647 G/A cg18131467 chr2:239335373 ASB1 -0.7 -6.18 -0.32 1.91e-9 Morning vs. evening chronotype;Chronotype; CRC cis rs9322193 0.923 rs9285524 chr6:150015258 G/A cg00933542 chr6:150070202 PCMT1 0.28 5.65 0.3 3.5e-8 Lung cancer; CRC cis rs10463316 0.894 rs6891272 chr5:150762842 G/T cg03212797 chr5:150827313 SLC36A1 -0.5 -7.78 -0.39 9.41e-14 Metabolite levels (Pyroglutamine); CRC cis rs7089973 0.872 rs7909566 chr10:116629136 A/G cg23260525 chr10:116636907 FAM160B1 0.31 6.75 0.35 6.66e-11 Bipolar disorder or attention deficit hyperactivity disorder; CRC cis rs6088580 0.634 rs6142153 chr20:32968747 C/G cg08999081 chr20:33150536 PIGU -0.62 -11.55 -0.54 3.9e-26 Glomerular filtration rate (creatinine); CRC trans rs45509595 0.841 rs2747054 chr6:27783359 A/G cg06606381 chr12:133084897 FBRSL1 -0.78 -6.64 -0.34 1.26e-10 Breast cancer; CRC cis rs1538970 0.781 rs713358 chr1:45988267 C/G cg05343316 chr1:45956843 TESK2 0.74 9.75 0.47 6.69e-20 Platelet count; CRC cis rs1887596 0.672 rs4771002 chr13:27201568 A/G cg01312412 chr13:27282625 NA 0.45 5.72 0.3 2.43e-8 Facial morphology (factor 3, length of philtrum); CRC cis rs916888 0.821 rs199507 chr17:44858855 A/G cg17911788 chr17:44343683 NA 0.56 6.86 0.35 3.4e-11 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC trans rs1455244 0.700 rs7229302 chr18:11508904 G/T cg21194140 chr2:128568865 WDR33 0.38 5.99 0.31 5.48e-9 Schizophrenia; CRC cis rs9875589 0.509 rs7614591 chr3:14061118 A/T cg14375111 chr3:14165186 TMEM43;CHCHD4 0.41 6.13 0.32 2.5e-9 Ovarian reserve; CRC cis rs10504229 1.000 rs55944282 chr8:58180821 A/G cg01721255 chr8:58191610 C8orf71 0.49 6.17 0.32 2e-9 Developmental language disorder (linguistic errors); CRC cis rs1348850 0.668 rs12618542 chr2:178494520 A/G cg27490568 chr2:178487706 NA 0.44 5.96 0.31 6.39e-9 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs6570726 0.791 rs9373464 chr6:145907167 T/C cg05347473 chr6:146136440 FBXO30 0.39 5.89 0.31 9.7e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs7264396 0.887 rs10359 chr20:34099789 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.42 -6.9 -0.36 2.72e-11 Total cholesterol levels; CRC cis rs4144743 1.000 rs4144745 chr17:45323349 T/C cg18085866 chr17:45331354 ITGB3 -0.59 -8.11 -0.41 1.02e-14 Body mass index; CRC cis rs1030877 1.000 rs2576743 chr2:105901337 C/T cg02079111 chr2:105885981 TGFBRAP1 0.65 11.84 0.55 3.5e-27 Obesity-related traits; CRC trans rs7726839 0.540 rs72703079 chr5:595173 T/C cg25482853 chr8:67687455 SGK3 1.06 12.52 0.57 1.15e-29 Obesity-related traits; CRC trans rs4650994 0.524 rs1998544 chr1:178605276 T/C cg05059571 chr16:84539110 KIAA1609 0.59 8.04 0.41 1.64e-14 HDL cholesterol levels;HDL cholesterol; CRC cis rs4400599 0.618 rs9943097 chr1:154205823 C/T cg26808167 chr1:154192205 UBAP2L;C1orf43 -0.36 -5.71 -0.3 2.49e-8 Platelet distribution width; CRC cis rs2179367 0.919 rs4897124 chr6:149763209 T/C cg07828024 chr6:149772892 ZC3H12D -0.4 -6.67 -0.35 1.06e-10 Dupuytren's disease; CRC cis rs870825 0.616 rs7660064 chr4:185617529 T/C cg04058563 chr4:185651563 MLF1IP 0.72 9.38 0.46 1.12e-18 Blood protein levels; CRC trans rs9650657 0.529 rs10108618 chr8:10953092 A/G cg08975724 chr8:8085496 FLJ10661 -0.43 -6.53 -0.34 2.56e-10 Neuroticism; CRC cis rs853679 0.517 rs9366715 chr6:28064633 A/G cg25164649 chr6:28176230 NA 0.75 9.32 0.46 1.72e-18 Depression; CRC cis rs1799949 0.526 rs4352088 chr17:41414679 A/G cg23758822 chr17:41437982 NA 0.81 13.62 0.6 8.16e-34 Menopause (age at onset); CRC cis rs947211 0.950 rs885224 chr1:205753097 A/G cg14159672 chr1:205819179 PM20D1 0.42 5.7 0.3 2.65e-8 Parkinson's disease; CRC cis rs9914988 0.619 rs12451955 chr17:27314224 A/G cg16670446 chr17:27188758 MIR451;MIR144 0.47 6.74 0.35 7.14e-11 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC trans rs2243480 1.000 rs34703416 chr7:65300642 A/G cg10756647 chr7:56101905 PSPH 0.74 7.77 0.39 9.91e-14 Diabetic kidney disease; CRC cis rs738321 0.725 rs9622738 chr22:38542346 G/A cg25457927 chr22:38595422 NA -0.32 -6.22 -0.32 1.52e-9 Breast cancer; CRC cis rs7727544 0.661 rs273900 chr5:131694606 G/A cg11843238 chr5:131593191 PDLIM4 0.33 6.08 0.32 3.27e-9 Blood metabolite levels; CRC cis rs853679 0.517 rs9393888 chr6:28059217 G/C cg12172441 chr6:28176163 NA 0.62 7.38 0.38 1.28e-12 Depression; CRC cis rs7944584 0.511 rs10838725 chr11:47557871 T/C cg20307385 chr11:47447363 PSMC3 0.85 12.58 0.57 7e-30 Fasting blood glucose;Fasting blood glucose (BMI interaction); CRC cis rs6740322 0.748 rs6727631 chr2:43470408 C/T cg06169590 chr2:43455088 ZFP36L2;LOC100129726 -0.75 -9.25 -0.45 3.03e-18 Coronary artery disease; CRC cis rs950776 1.000 rs950776 chr15:78926018 A/G cg06917634 chr15:78832804 PSMA4 0.54 8.3 0.42 2.76e-15 Sudden cardiac arrest; CRC cis rs6951245 1.000 rs79327308 chr7:1108141 A/C cg26224354 chr7:1096374 C7orf50;GPR146 -0.94 -12.26 -0.56 9.81e-29 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs6089584 0.854 rs6061985 chr20:60622362 T/C cg23463467 chr20:60627584 TAF4 0.34 5.96 0.31 6.58e-9 Body mass index; CRC cis rs752010 0.619 rs4393146 chr1:42118766 A/G cg06885757 chr1:42089581 HIVEP3 0.5 7.87 0.4 5.32e-14 Lupus nephritis in systemic lupus erythematosus; CRC cis rs12580194 0.556 rs61957898 chr12:55730423 T/C cg23425280 chr12:56401806 NA 0.47 5.93 0.31 7.72e-9 Cancer; CRC cis rs17711722 0.503 rs453835 chr7:65511159 T/A cg18876405 chr7:65276391 NA -0.5 -7.83 -0.4 6.78e-14 Calcium levels; CRC cis rs11971779 0.523 rs10279160 chr7:139090761 A/G cg23387468 chr7:139079360 LUC7L2 0.41 7.04 0.36 1.14e-11 Diisocyanate-induced asthma; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg00621029 chr21:35747559 FAM165B 0.46 6.71 0.35 8.39e-11 Intelligence (multi-trait analysis); CRC cis rs34779708 0.833 rs12777517 chr10:35473927 T/G cg03585969 chr10:35415529 CREM 0.61 8.25 0.41 3.92e-15 Inflammatory bowel disease;Crohn's disease; CRC cis rs875971 0.756 rs2901210 chr7:66017505 G/A cg11764359 chr7:65958608 NA -0.58 -8.7 -0.43 1.65e-16 Aortic root size; CRC cis rs2952156 0.920 rs2517953 chr17:37841211 G/C cg07936489 chr17:37558343 FBXL20 -0.46 -6.63 -0.34 1.4e-10 Asthma; CRC cis rs9916302 0.851 rs4390625 chr17:37620347 A/G cg15445000 chr17:37608096 MED1 0.43 9.47 0.46 5.76e-19 Glomerular filtration rate (creatinine); CRC cis rs9368481 0.524 rs12530345 chr6:26884243 T/C cg18278486 chr6:26987575 LOC100270746;C6orf41 0.39 6.0 0.31 5.13e-9 Autism spectrum disorder or schizophrenia; CRC cis rs2415984 0.622 rs8022305 chr14:46946545 C/T cg14871534 chr14:47121158 RPL10L -0.44 -6.23 -0.32 1.44e-9 Number of children ever born; CRC cis rs2777491 0.915 rs8032838 chr15:41605632 G/A cg18705301 chr15:41695430 NDUFAF1 -0.69 -11.44 -0.53 9.35e-26 Ulcerative colitis; CRC cis rs13118159 0.771 rs13117476 chr4:1334721 A/G cg24560729 chr4:1342394 KIAA1530 0.43 7.81 0.4 7.72e-14 Longevity; CRC cis rs5769765 0.646 rs9627789 chr22:50300562 A/G cg22709217 chr22:50311962 ALG12;CRELD2 -0.85 -12.11 -0.56 3.58e-28 Schizophrenia; CRC cis rs6088590 0.707 rs67159833 chr20:33488079 T/C cg24642439 chr20:33292090 TP53INP2 0.53 8.32 0.42 2.32e-15 Coronary artery disease; CRC cis rs644799 1.000 rs488246 chr11:95560473 T/C cg25622487 chr11:95524042 FAM76B;CEP57 0.76 11.99 0.55 9.59e-28 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs10791323 0.569 rs10750542 chr11:133713436 T/C cg06766960 chr11:133703094 NA -0.35 -5.94 -0.31 7.3e-9 Childhood ear infection; CRC cis rs2717559 0.542 rs2717586 chr8:143897882 C/T cg20041105 chr8:143859282 LYNX1 0.69 12.48 0.57 1.61e-29 Urinary tract infection frequency; CRC trans rs12257178 0.532 rs12263857 chr10:113006704 A/G cg23061718 chr2:73143321 EMX1 -0.45 -6.18 -0.32 1.89e-9 Longitudinal alcohol consumption; CRC cis rs863345 0.604 rs6674656 chr1:158495431 G/A cg12129480 chr1:158549410 OR10X1 -0.29 -5.95 -0.31 6.94e-9 Pneumococcal bacteremia; CRC cis rs600626 0.636 rs11236516 chr11:75451668 C/T cg24262691 chr11:75473276 NA -0.55 -7.57 -0.39 3.73e-13 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CRC trans rs11039798 0.688 rs10839007 chr11:48703442 A/C cg03929089 chr4:120376271 NA 0.63 6.06 0.32 3.73e-9 Axial length; CRC cis rs2153535 0.580 rs6918391 chr6:8461178 A/C cg07606381 chr6:8435919 SLC35B3 0.68 10.91 0.52 7.65e-24 Motion sickness; CRC cis rs847577 0.677 rs951988 chr7:97762474 C/G cg21770322 chr7:97807741 LMTK2 -0.69 -12.67 -0.57 3.21e-30 Breast cancer; CRC cis rs2797160 1.000 rs1739362 chr6:126020703 A/T cg05901451 chr6:126070800 HEY2 0.39 6.04 0.32 4.14e-9 Endometrial cancer; CRC cis rs1552244 0.515 rs7613004 chr3:9999913 A/C cg18598329 chr3:10140678 FANCD2;C3orf24 -0.52 -7.53 -0.38 5.05e-13 Alzheimer's disease; CRC cis rs2415984 0.579 rs10135740 chr14:46957379 G/A cg14871534 chr14:47121158 RPL10L -0.41 -5.79 -0.3 1.63e-8 Number of children ever born; CRC cis rs826838 0.616 rs10880751 chr12:38627485 C/T cg13010199 chr12:38710504 ALG10B 0.44 6.33 0.33 8.24e-10 Heart rate; CRC cis rs13108904 0.870 rs13110563 chr4:1255772 G/C cg02018176 chr4:1364513 KIAA1530 0.45 7.56 0.38 4.18e-13 Obesity-related traits; CRC cis rs9811920 0.609 rs4928232 chr3:99694217 G/A cg07805332 chr3:99536008 MIR548G;C3orf26 0.51 7.68 0.39 1.84e-13 Axial length; CRC cis rs1799949 0.526 rs4352088 chr17:41414679 A/G cg01879757 chr17:41196368 BRCA1 -0.41 -6.09 -0.32 3.11e-9 Menopause (age at onset); CRC cis rs16867321 0.901 rs768116 chr2:181511012 A/G cg23363182 chr2:181467187 NA -0.5 -6.3 -0.33 9.76e-10 Obesity; CRC cis rs6545883 0.868 rs7608483 chr2:61836235 A/C cg15711740 chr2:61764176 XPO1 -0.56 -7.72 -0.39 1.43e-13 Tuberculosis; CRC cis rs17155006 0.746 rs370495 chr7:107746246 T/C cg05962710 chr7:107745446 LAMB4 -0.41 -7.26 -0.37 2.9e-12 Pneumococcal bacteremia; CRC cis rs2075371 0.897 rs1643102 chr7:133999983 T/A cg02659138 chr7:134003124 SLC35B4 0.42 7.36 0.38 1.49e-12 Mean platelet volume; CRC cis rs9462027 0.585 rs188190 chr6:34551086 C/T cg07306190 chr6:34760872 UHRF1BP1 -0.34 -5.92 -0.31 7.97e-9 Systemic lupus erythematosus; CRC cis rs7394190 0.748 rs2306325 chr10:75506674 T/C cg07699608 chr10:75541558 CHCHD1 0.62 6.37 0.33 6.37e-10 Incident atrial fibrillation; CRC cis rs13191362 1.000 rs13218900 chr6:163081638 T/C cg23758597 chr6:163146217 PARK2 -0.65 -6.52 -0.34 2.68e-10 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg02698620 chr7:45026579 C7orf40;SNORA9 0.43 6.06 0.32 3.77e-9 Response to antipsychotic treatment; CRC cis rs3820068 0.581 rs6666373 chr1:15939884 A/T cg24675056 chr1:15929824 NA 0.49 6.75 0.35 6.85e-11 Systolic blood pressure; CRC cis rs514406 0.565 rs897732 chr1:53382816 A/C cg08859206 chr1:53392774 SCP2 -0.59 -9.11 -0.45 8.17e-18 Monocyte count; CRC cis rs2795502 1.000 rs2744090 chr10:43339614 G/C cg27426351 chr10:43362370 NA -0.6 -7.12 -0.37 6.96e-12 Blood protein levels; CRC cis rs10499694 0.933 rs998850 chr7:50607388 G/C cg14593290 chr7:50529359 DDC -0.45 -6.52 -0.34 2.72e-10 Body mass index; CRC cis rs60871478 0.636 rs10245785 chr7:894422 T/C cg13798912 chr7:905769 UNC84A -0.63 -6.84 -0.35 3.98e-11 Cerebrospinal P-tau181p levels; CRC cis rs1448094 0.791 rs10863110 chr12:86328523 T/C cg25456477 chr12:86230367 RASSF9 0.34 5.74 0.3 2.14e-8 Major depressive disorder; CRC cis rs9468186 1 rs9468186 chr6:27626631 A/G cg06470822 chr6:28175283 NA 0.51 6.12 0.32 2.69e-9 Neuroticism; CRC cis rs11148252 0.904 rs9536079 chr13:53030565 G/A cg12458913 chr13:53173898 NA 0.59 9.3 0.46 1.98e-18 Lewy body disease; CRC cis rs9858542 0.953 rs34588335 chr3:49407660 G/C cg07274523 chr3:49395745 GPX1 0.45 6.05 0.32 4.03e-9 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs1580019 0.547 rs56981934 chr7:32535202 C/G cg07520158 chr7:32535189 LSM5;AVL9 0.54 8.04 0.41 1.62e-14 Cognitive ability; CRC cis rs2160860 1.000 rs2160860 chr8:39823145 A/T cg11363097 chr8:39792086 IDO2 0.34 5.62 0.3 4.12e-8 Blood metabolite levels; CRC cis rs12701220 0.948 rs10275712 chr7:1082918 G/A cg26769984 chr7:1090371 C7orf50 0.75 10.38 0.5 4.95e-22 Bronchopulmonary dysplasia; CRC cis rs2153535 0.580 rs1335636 chr6:8465047 T/C cg21535247 chr6:8435926 SLC35B3 0.5 7.53 0.38 4.89e-13 Motion sickness; CRC cis rs10479542 0.784 rs4701132 chr5:178985270 A/G cg21226059 chr5:178986404 RUFY1 -0.42 -7.74 -0.39 1.22e-13 Lung cancer; CRC cis rs5750830 0.649 rs5750822 chr22:39826788 C/T cg05872129 chr22:39784769 NA -0.62 -12.21 -0.56 1.52e-28 Intelligence (multi-trait analysis); CRC cis rs1867631 0.585 rs6670827 chr1:67127006 C/T cg02459107 chr1:67143332 SGIP1 0.36 6.3 0.33 9.67e-10 Menopause (age at onset); CRC cis rs3858526 0.883 rs10769326 chr11:5934358 C/T cg02574844 chr11:5959923 NA -0.42 -6.02 -0.31 4.69e-9 DNA methylation (variation); CRC cis rs875971 0.545 rs17138149 chr7:65693180 A/G cg03233332 chr7:66118400 NA -0.42 -5.89 -0.31 9.7e-9 Aortic root size; CRC cis rs6968419 0.755 rs17138483 chr7:115893845 A/C cg02561103 chr7:115862891 TES -0.43 -6.47 -0.34 3.64e-10 Intraocular pressure; CRC cis rs79387448 0.745 rs7583683 chr2:103113763 C/T cg09003973 chr2:102972529 NA -0.73 -8.06 -0.41 1.39e-14 Gut microbiota (bacterial taxa); CRC cis rs875971 0.508 rs10258739 chr7:66062935 A/T cg18876405 chr7:65276391 NA -0.59 -10.55 -0.5 1.35e-22 Aortic root size; CRC cis rs9443189 0.570 rs7765254 chr6:76398143 T/C cg01950844 chr6:76311363 SENP6 0.71 8.68 0.43 1.85e-16 Prostate cancer; CRC trans rs3780486 0.522 rs7029897 chr9:33124042 T/C cg20290983 chr6:43655470 MRPS18A 0.97 18.04 0.71 4.72e-51 IgG glycosylation; CRC cis rs72772090 0.634 rs72773912 chr5:96107801 A/G cg17330273 chr5:96107758 CAST;ERAP1 -0.68 -6.36 -0.33 6.85e-10 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs4604732 0.631 rs35046441 chr1:247626812 G/A cg12754571 chr1:247694271 LOC148824;OR2C3 0.41 5.78 0.3 1.74e-8 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CRC cis rs9611565 0.605 rs202638 chr22:41855458 A/G cg03806693 chr22:41940476 POLR3H 0.8 10.66 0.51 5.55e-23 Vitiligo; CRC cis rs2836974 0.931 rs13047663 chr21:40708818 C/T cg11644478 chr21:40555479 PSMG1 0.64 8.94 0.44 2.9e-17 Cognitive function; CRC cis rs6604026 0.883 rs10874745 chr1:93321541 G/A cg22128645 chr1:93425802 FAM69A -0.39 -5.91 -0.31 8.54e-9 Multiple sclerosis; CRC cis rs780096 0.587 rs1049817 chr2:27550967 A/G cg21248554 chr2:27665150 KRTCAP3 -0.27 -6.22 -0.32 1.48e-9 Total body bone mineral density; CRC cis rs6728642 0.908 rs10203833 chr2:98017363 G/A cg26665480 chr2:98280029 ACTR1B -0.52 -6.1 -0.32 2.93e-9 Bipolar disorder lithium response (continuous) or schizophrenia; CRC cis rs3026101 0.624 rs1065483 chr17:5284770 C/T cg25236894 chr17:5323110 RPAIN;NUP88 0.49 8.44 0.42 1.06e-15 Body mass index; CRC cis rs3015497 0.753 rs12881776 chr14:51136330 T/G cg09863266 chr14:51125203 SAV1 -0.31 -5.75 -0.3 2.08e-8 Mean platelet volume; CRC cis rs826838 0.967 rs7136593 chr12:39128265 C/T cg26384229 chr12:38710491 ALG10B -0.64 -9.67 -0.47 1.21e-19 Heart rate; CRC cis rs72945132 0.882 rs66989619 chr11:70202127 G/C cg00319359 chr11:70116639 PPFIA1 0.55 6.04 0.32 4.16e-9 Coronary artery disease; CRC cis rs9814567 1.000 rs2056603 chr3:134312749 T/C cg06109529 chr3:134205091 CEP63;ANAPC13 -0.81 -12.14 -0.56 2.75e-28 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs853679 0.542 rs9393892 chr6:28081394 A/G cg18032046 chr6:28092343 ZSCAN16 -0.5 -5.83 -0.31 1.31e-8 Depression; CRC cis rs2576037 0.526 rs2051292 chr18:44484372 C/G cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.5 8.09 0.41 1.13e-14 Personality dimensions; CRC cis rs72781680 0.898 rs72796396 chr2:24178154 G/A cg08917208 chr2:24149416 ATAD2B 0.9 9.17 0.45 5.14e-18 Lymphocyte counts; CRC cis rs780096 0.526 rs4582 chr2:27604279 A/G cg12000995 chr2:27665139 KRTCAP3 -0.3 -6.14 -0.32 2.44e-9 Total body bone mineral density; CRC cis rs7618915 0.547 rs13065019 chr3:52685244 T/C cg10802521 chr3:52805072 NEK4 -0.58 -9.01 -0.44 1.77e-17 Bipolar disorder; CRC cis rs10504229 0.775 rs72650876 chr8:58161638 G/A cg21724239 chr8:58056113 NA 0.65 8.51 0.42 6.42e-16 Developmental language disorder (linguistic errors); CRC cis rs7811142 0.775 rs1636980 chr7:99938864 A/G cg13153964 chr7:100026424 MEPCE;ZCWPW1 -1.12 -16.19 -0.67 9e-44 Platelet count; CRC cis rs644799 1.000 rs12786522 chr11:95522858 G/C cg25622487 chr11:95524042 FAM76B;CEP57 0.76 11.79 0.55 5.26e-27 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs1005277 0.540 rs2474598 chr10:38430296 C/T cg00409905 chr10:38381863 ZNF37A 0.67 10.9 0.52 8.12e-24 Extrinsic epigenetic age acceleration; CRC cis rs10791323 0.628 rs2853117 chr11:133705266 T/G cg03690763 chr11:133734501 NA -0.34 -5.73 -0.3 2.33e-8 Childhood ear infection; CRC cis rs2276314 0.857 rs72883058 chr18:33612917 G/A cg05985134 chr18:33552581 C18orf21 0.47 6.37 0.33 6.45e-10 Endometriosis;Drug-induced torsades de pointes; CRC cis rs6088590 0.561 rs6059926 chr20:33164804 C/T cg24642439 chr20:33292090 TP53INP2 0.4 6.85 0.35 3.65e-11 Coronary artery disease; CRC cis rs6973256 0.897 rs17659708 chr7:133355098 A/G cg10665199 chr7:133106180 EXOC4 -0.36 -5.68 -0.3 2.96e-8 Intelligence (multi-trait analysis); CRC cis rs9372498 0.536 rs9481833 chr6:118919631 G/A cg07617317 chr6:118971624 C6orf204 0.49 6.07 0.32 3.58e-9 Diastolic blood pressure; CRC cis rs6502050 0.698 rs36043222 chr17:80117822 G/T cg25804541 chr17:80189381 SLC16A3 -0.31 -5.98 -0.31 5.73e-9 Life satisfaction; CRC cis rs3812762 0.868 rs7934519 chr11:8791981 A/G cg00186954 chr11:8933980 ST5;C11orf17 0.38 6.09 0.32 3.17e-9 Hypospadias; CRC cis rs17376456 0.825 rs56108532 chr5:93276342 C/T cg21475434 chr5:93447410 FAM172A 0.79 7.98 0.4 2.44e-14 Diabetic retinopathy; CRC cis rs7095944 0.614 rs1055256 chr10:126446592 A/G cg08799069 chr10:126477246 METTL10 -0.42 -6.54 -0.34 2.3e-10 Asthma; CRC cis rs7215564 0.822 rs2340771 chr17:78752947 A/C cg09596252 chr17:78655493 RPTOR -0.59 -6.2 -0.32 1.7e-9 Myopia (pathological); CRC cis rs9648716 0.872 rs6964937 chr7:140609690 C/G cg17554604 chr7:140774522 NA 0.45 5.67 0.3 3.12e-8 Type 2 diabetes; CRC cis rs45544231 0.544 rs1420535 chr16:52578215 C/A cg09051775 chr16:52580266 TOX3 -0.4 -6.51 -0.34 2.87e-10 Restless legs syndrome; CRC cis rs3800461 0.509 rs73407707 chr6:34476644 T/G cg17674042 chr6:34482479 PACSIN1 -0.99 -10.92 -0.52 6.77e-24 Chronic lymphocytic leukemia; CRC cis rs10256972 0.758 rs9801444 chr7:1080444 A/C cg03923535 chr7:1197113 ZFAND2A -0.49 -6.99 -0.36 1.58e-11 Longevity;Endometriosis; CRC cis rs10504229 0.683 rs61201557 chr8:58138370 T/C cg21724239 chr8:58056113 NA 0.49 6.81 0.35 4.75e-11 Developmental language disorder (linguistic errors); CRC trans rs6076960 0.684 rs6038408 chr20:6268983 A/C cg17788362 chr6:86352627 SYNCRIP 0.56 7.59 0.39 3.27e-13 Smooth-surface caries; CRC cis rs853679 0.517 rs9368555 chr6:28108967 T/C cg15845792 chr6:28175446 NA 1.04 13.89 0.61 7.67e-35 Depression; CRC cis rs2274273 0.901 rs8011288 chr14:55735112 C/T cg23234261 chr14:55582407 NA -0.28 -5.66 -0.3 3.3e-8 Protein biomarker; CRC cis rs9583531 0.689 rs9521905 chr13:111352600 G/A cg24331049 chr13:111365604 ING1 -0.63 -7.93 -0.4 3.48e-14 Coronary artery disease; CRC cis rs1670533 1.000 rs1670533 chr4:1078187 G/A cg27284194 chr4:1044797 NA 0.49 6.24 0.33 1.37e-9 Recombination rate (females); CRC cis rs9296736 0.922 rs625899 chr6:53957588 C/T cg04374786 chr6:53939321 C6orf142 -0.43 -7.11 -0.36 7.31e-12 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs4713118 0.513 rs149962 chr6:28015918 G/A cg25164649 chr6:28176230 NA 0.59 8.38 0.42 1.56e-15 Parkinson's disease; CRC cis rs1008375 0.966 rs4235391 chr4:17696409 A/G cg16339924 chr4:17578868 LAP3 0.49 6.6 0.34 1.68e-10 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs4819052 0.851 rs2838866 chr21:46713014 G/C cg02159808 chr21:46707872 POFUT2;LOC642852 0.52 6.78 0.35 5.51e-11 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC trans rs2303319 0.504 rs62187570 chr2:162373899 C/G cg27113153 chr11:123612418 ZNF202 -0.72 -6.17 -0.32 1.96e-9 Cognitive function; CRC cis rs4728302 0.869 rs10224575 chr7:133590875 G/A cg10665199 chr7:133106180 EXOC4 0.38 5.85 0.31 1.22e-8 Intelligence;Intelligence (multi-trait analysis); CRC trans rs6550704 0.687 rs9865314 chr3:22634337 A/G cg04071446 chr10:115933849 C10orf118 -0.44 -6.46 -0.34 3.84e-10 Daytime sleep phenotypes; CRC cis rs2160860 0.729 rs55992954 chr8:39801619 T/C cg11363097 chr8:39792086 IDO2 -0.45 -7.58 -0.39 3.66e-13 Blood metabolite levels; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg25356086 chr21:33764900 C21orf119;URB1 0.46 6.0 0.31 5.12e-9 Thyroid stimulating hormone; CRC cis rs17095355 1.000 rs12570612 chr10:111717685 C/T cg00817464 chr10:111662876 XPNPEP1 0.53 7.26 0.37 2.82e-12 Biliary atresia; CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg03758392 chr3:184870408 C3orf70 -0.55 -6.72 -0.35 8.13e-11 Diisocyanate-induced asthma; CRC cis rs6942756 0.876 rs57263220 chr7:129010858 C/A cg02491457 chr7:128862824 NA -0.64 -8.78 -0.44 9.28e-17 White matter hyperintensity burden; CRC trans rs7395662 1.000 rs7948486 chr11:48912140 C/G cg21153622 chr11:89784906 NA 0.45 7.1 0.36 7.58e-12 HDL cholesterol; CRC cis rs1707322 0.717 rs11211161 chr1:46148138 A/C cg03146154 chr1:46216737 IPP 0.67 9.69 0.47 1.09e-19 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs977987 0.788 rs7184525 chr16:75437186 A/G cg03315344 chr16:75512273 CHST6 0.54 9.08 0.45 1.01e-17 Dupuytren's disease; CRC cis rs798766 1.000 rs798719 chr4:1698183 C/T cg05874882 chr4:1763078 NA -0.36 -6.63 -0.34 1.4e-10 Bladder cancer;Urinary bladder cancer; CRC cis rs9311474 0.632 rs6445528 chr3:52572447 C/T cg18099408 chr3:52552593 STAB1 0.54 9.79 0.48 4.84e-20 Electroencephalogram traits; CRC cis rs758324 0.947 rs1500115 chr5:131216427 G/T cg06307176 chr5:131281290 NA 0.43 6.35 0.33 7.21e-10 Alzheimer's disease in APOE e4- carriers; CRC trans rs7726839 0.540 rs4957081 chr5:646418 G/C cg25482853 chr8:67687455 SGK3 1.13 13.26 0.59 1.97e-32 Obesity-related traits; CRC cis rs1519814 0.654 rs1543201 chr8:121018888 A/T cg22335954 chr8:121166405 COL14A1 0.51 5.64 0.3 3.75e-8 Breast cancer; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg08636040 chr1:151171017 PIP5K1A 0.46 6.25 0.33 1.28e-9 Response to antipsychotic treatment; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg00349599 chr17:17184369 COPS3 0.48 6.78 0.35 5.5e-11 Response to antipsychotic treatment; CRC cis rs6662572 0.737 rs9429179 chr1:46514198 A/G cg03123370 chr1:45965343 CCDC163P;MMACHC 0.47 6.12 0.32 2.7e-9 Blood protein levels; CRC cis rs2204008 0.837 rs1589395 chr12:38420405 C/T cg26384229 chr12:38710491 ALG10B 0.7 9.8 0.48 4.54e-20 Bladder cancer; CRC cis rs62244186 0.748 rs12635624 chr3:44678498 G/A cg11003573 chr3:44754125 ZNF502 -0.36 -6.19 -0.32 1.74e-9 Depressive symptoms; CRC cis rs7246657 0.943 rs2081096 chr19:37964700 G/A cg23950597 chr19:37808831 NA -0.47 -5.73 -0.3 2.21e-8 Coronary artery calcification; CRC trans rs2727020 0.894 rs2866361 chr11:49372481 A/G cg03929089 chr4:120376271 NA -0.71 -9.31 -0.46 1.89e-18 Coronary artery disease; CRC cis rs9039 1.000 rs9932208 chr16:9218267 T/C cg08831531 chr16:9218945 NA -0.63 -8.89 -0.44 3.99e-17 Menopause (age at onset); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg23333220 chr15:64679825 TRIP4 0.42 6.03 0.32 4.45e-9 Response to antipsychotic treatment; CRC cis rs889398 0.802 rs2937121 chr16:69870409 T/G cg00738113 chr16:70207722 CLEC18C 0.36 6.12 0.32 2.68e-9 Body mass index; CRC cis rs68170813 0.559 rs78610616 chr7:106951369 T/C cg02696742 chr7:106810147 HBP1 -0.58 -6.27 -0.33 1.11e-9 Coronary artery disease; CRC cis rs17270561 0.666 rs9356987 chr6:25739187 C/A cg16482183 chr6:26056742 HIST1H1C 0.83 10.58 0.5 1.07e-22 Iron status biomarkers; CRC cis rs3018066 0.748 rs28897193 chr4:107005529 G/C cg01869342 chr4:106983673 TBCK 0.42 6.28 0.33 1.07e-9 Cancer; CRC cis rs2730260 0.800 rs73169218 chr7:158836906 T/A cg02254261 chr7:158964346 NA -0.57 -6.32 -0.33 8.37e-10 Myopia (pathological); CRC cis rs1153858 0.945 rs7182300 chr15:45634928 G/A cg21132104 chr15:45694354 SPATA5L1 0.57 8.46 0.42 8.9e-16 Homoarginine levels; CRC cis rs9948 0.529 rs62156208 chr2:97383686 A/G cg20312557 chr2:97357134 FER1L5 -0.61 -5.67 -0.3 3.19e-8 Erectile dysfunction and prostate cancer treatment; CRC cis rs7917772 0.582 rs4917973 chr10:104333700 C/T cg11453585 chr10:104263688 ACTR1A;SUFU 0.82 15.26 0.64 3.8e-40 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC cis rs3825932 0.961 rs11856301 chr15:79232330 T/C cg25744700 chr15:79237217 CTSH 0.39 6.07 0.32 3.61e-9 Type 1 diabetes; CRC trans rs11031096 0.738 rs1980412 chr11:4148948 C/T cg22978087 chr8:24814126 NEFL 0.33 6.06 0.32 3.75e-9 Mean corpuscular volume;Mean corpuscular hemoglobin; CRC cis rs3736485 0.932 rs2899477 chr15:51937701 C/T cg08986416 chr15:51914746 DMXL2 -0.46 -6.55 -0.34 2.16e-10 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs929354 0.713 rs7798816 chr7:156940574 A/G cg17757837 chr7:157058334 UBE3C 0.74 12.39 0.56 3.31e-29 Body mass index; CRC cis rs9916302 0.904 rs12952384 chr17:37669536 T/C cg07936489 chr17:37558343 FBXL20 -0.84 -13.25 -0.59 2.04e-32 Glomerular filtration rate (creatinine); CRC cis rs736408 0.509 rs3774349 chr3:52722335 A/C cg15147215 chr3:52552868 STAB1 -0.71 -13.09 -0.59 8.66e-32 Bipolar disorder; CRC cis rs13392177 0.672 rs1877715 chr2:219052546 C/T cg00012203 chr2:219082015 ARPC2 0.52 8.25 0.41 3.91e-15 Pyoderma gangrenosum in inflammatory bowel disease; CRC cis rs274567 0.501 rs272856 chr5:131687081 G/C cg27615366 chr5:131592974 PDLIM4 0.33 5.65 0.3 3.56e-8 Blood metabolite levels; CRC cis rs7818382 0.967 rs7812465 chr8:96050557 C/T cg13393036 chr8:95962371 TP53INP1 0.49 8.08 0.41 1.26e-14 Alzheimer's disease (late onset); CRC cis rs6951245 0.872 rs74360401 chr7:1067403 G/A cg22907277 chr7:1156413 C7orf50 0.71 7.39 0.38 1.26e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs853679 0.517 rs9393891 chr6:28079160 C/T cg25164649 chr6:28176230 NA 0.77 9.5 0.46 4.6e-19 Depression; CRC cis rs5769765 0.773 rs7290751 chr22:50318312 T/C cg02269571 chr22:50332266 NA -0.62 -7.71 -0.39 1.5e-13 Schizophrenia; CRC cis rs524281 0.861 rs1862005 chr11:65863402 T/C cg16950941 chr11:66035639 RAB1B -0.6 -7.39 -0.38 1.23e-12 Electroencephalogram traits; CRC cis rs9733 0.596 rs12086630 chr1:150650955 T/C cg17724175 chr1:150552817 MCL1 0.58 9.4 0.46 9.25e-19 Tonsillectomy; CRC cis rs7412746 0.611 rs7532045 chr1:150821847 G/A cg15448220 chr1:150897856 SETDB1 0.46 6.44 0.33 4.17e-10 Melanoma; CRC cis rs7107174 1.000 rs10793300 chr11:78019582 T/A cg02023728 chr11:77925099 USP35 0.54 7.6 0.39 3.18e-13 Testicular germ cell tumor; CRC cis rs3751196 0.901 rs12423994 chr12:104194263 A/G cg02344784 chr12:104178138 NT5DC3 0.69 7.05 0.36 1.07e-11 Sense of smell; CRC cis rs911119 0.955 rs8116859 chr20:23590703 A/T cg16589663 chr20:23618590 CST3 0.45 6.27 0.33 1.12e-9 Chronic kidney disease; CRC cis rs2836950 0.545 rs2836956 chr21:40623018 C/G cg11890956 chr21:40555474 PSMG1 0.61 8.93 0.44 2.98e-17 Menarche (age at onset); CRC cis rs6912958 0.605 rs2754247 chr6:88383571 A/G cg08069147 chr6:88032118 GJB7;C6orf162 -0.54 -7.94 -0.4 3.21e-14 Monocyte percentage of white cells; CRC cis rs7773004 1.000 rs1155207 chr6:26328365 A/G cg00631329 chr6:26305371 NA -0.47 -7.89 -0.4 4.6e-14 Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for body mass index;Waist circumference adjusted for BMI in non-smokers;Waist circumference adjusted for BMI (adjusted for smoking behaviour); CRC cis rs7300001 0.510 rs73205064 chr12:110512546 A/G cg12870014 chr12:110450643 ANKRD13A 0.79 7.17 0.37 5.14e-12 Headache; CRC trans rs875971 0.660 rs2191268 chr7:66110224 C/T cg11637544 chr11:66886765 KDM2A -0.39 -6.17 -0.32 1.95e-9 Aortic root size; CRC cis rs7914558 0.966 rs10748837 chr10:104880236 T/C cg15744005 chr10:104629667 AS3MT -0.34 -7.28 -0.37 2.51e-12 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs7493 1.000 rs3735586 chr7:95035582 A/T cg20119798 chr7:94954144 PON1 -0.48 -6.18 -0.32 1.9e-9 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs769267 0.965 rs4808200 chr19:19554803 C/T cg01262667 chr19:19385393 TM6SF2 0.36 5.73 0.3 2.22e-8 Tonsillectomy; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg24847481 chr1:100435557 SLC35A3 0.46 8.06 0.41 1.38e-14 Liver disease severity in Alagille syndrome; CRC cis rs9303401 0.614 rs34941454 chr17:57102742 T/G cg10487724 chr17:56770010 TEX14;RAD51C 0.71 8.91 0.44 3.45e-17 Cognitive test performance; CRC cis rs539514 0.690 rs776527 chr13:76317794 G/A cg04757411 chr13:76259545 LMO7 -0.35 -5.91 -0.31 8.52e-9 Type 1 diabetes; CRC trans rs561341 0.769 rs7217004 chr17:30178092 A/G cg27661571 chr11:113659931 NA 0.72 7.69 0.39 1.71e-13 Hip circumference adjusted for BMI; CRC cis rs1816752 0.805 rs4769353 chr13:25000456 A/G cg02811702 chr13:24901961 NA 0.45 6.22 0.32 1.53e-9 Obesity-related traits; CRC cis rs1153858 1.000 rs67744121 chr15:45677237 C/G cg10760299 chr15:45669010 GATM 0.5 7.82 0.4 7.18e-14 Homoarginine levels; CRC cis rs40363 0.645 rs1690450 chr16:3521051 G/A cg05754148 chr16:3507555 NAT15 0.46 6.56 0.34 2.06e-10 Tuberculosis; CRC cis rs3733585 0.673 rs4627861 chr4:9954238 T/G cg00071950 chr4:10020882 SLC2A9 -0.55 -9.74 -0.47 7.09e-20 Cleft plate (environmental tobacco smoke interaction); CRC cis rs2878628 0.596 rs57039206 chr3:52758570 T/A cg11645453 chr3:52864694 ITIH4 0.37 6.55 0.34 2.23e-10 Intelligence (multi-trait analysis); CRC cis rs9487051 0.872 rs9487033 chr6:109605388 C/G cg21918786 chr6:109611834 NA 0.46 8.32 0.42 2.45e-15 Reticulocyte fraction of red cells; CRC cis rs9533799 1.000 rs9533798 chr13:44802505 C/G cg19190762 chr13:44806055 NA -0.63 -9.77 -0.47 5.97e-20 Amyotrophic lateral sclerosis; CRC cis rs780096 0.526 rs13391837 chr2:27649375 A/G cg27432699 chr2:27873401 GPN1 -0.57 -8.68 -0.43 1.86e-16 Total body bone mineral density; CRC trans rs7555117 0.510 rs12073874 chr1:61026145 G/A cg16795821 chr3:142720237 SR140 -0.38 -6.4 -0.33 5.4e-10 Facial morphology (factor 19); CRC cis rs806215 0.950 rs3735642 chr7:127224286 A/G cg25922125 chr7:127225783 GCC1 -0.62 -6.67 -0.35 1.1e-10 Type 2 diabetes; CRC cis rs28386778 0.897 rs2665833 chr17:61906846 T/C cg11494091 chr17:61959527 GH2 0.6 10.23 0.49 1.6e-21 Prudent dietary pattern; CRC cis rs4713118 0.513 rs156734 chr6:28007357 A/C cg03623178 chr6:28175578 NA 0.77 11.51 0.54 5.68e-26 Parkinson's disease; CRC cis rs4332037 0.539 rs11762545 chr7:2060775 C/T cg25834613 chr7:1915315 MAD1L1 -0.41 -5.89 -0.31 9.69e-9 Bipolar disorder; CRC trans rs7615952 0.733 rs13314847 chr3:125644788 C/T cg02007433 chr3:129722099 NA -0.46 -6.25 -0.33 1.3e-9 Blood pressure (smoking interaction); CRC cis rs3768617 0.510 rs1413390 chr1:183096634 G/A ch.1.3577855R chr1:183094577 LAMC1 0.89 15.86 0.66 1.84e-42 Fuchs's corneal dystrophy; CRC cis rs4713118 0.868 rs35069907 chr6:27746692 T/C cg06470822 chr6:28175283 NA 0.82 9.31 0.46 1.94e-18 Parkinson's disease; CRC cis rs28386778 0.897 rs2665832 chr17:61912261 C/T cg22520471 chr17:61851767 DDX42;CCDC47 0.75 11.85 0.55 3.21e-27 Prudent dietary pattern; CRC cis rs2072499 0.966 rs2842882 chr1:156165342 T/G cg24450063 chr1:156163899 SLC25A44 1.15 27.57 0.84 1.66e-87 Testicular germ cell tumor; CRC cis rs12950390 0.853 rs17700008 chr17:45863591 A/C cg24803719 chr17:45855879 NA 0.29 6.47 0.34 3.48e-10 IgG glycosylation; CRC cis rs6545883 0.931 rs12713437 chr2:61722904 C/T cg15711740 chr2:61764176 XPO1 -0.51 -6.93 -0.36 2.29e-11 Tuberculosis; CRC cis rs2980436 1 rs2980436 chr8:8092025 A/G cg06636001 chr8:8085503 FLJ10661 -0.72 -10.98 -0.52 4.19e-24 Schizophrenia; CRC cis rs7647973 0.769 rs6772452 chr3:49040462 A/G cg07636037 chr3:49044803 WDR6 0.87 12.32 0.56 6.03e-29 Menarche (age at onset); CRC cis rs8031584 0.918 rs35784593 chr15:31254588 G/A cg14829155 chr15:31115871 NA -0.5 -8.13 -0.41 8.87e-15 Huntington's disease progression; CRC cis rs4891159 0.790 rs72973773 chr18:74115176 T/C cg24786174 chr18:74118243 ZNF516 -0.9 -16.28 -0.67 4.12e-44 Longevity; CRC cis rs1707322 0.721 rs11211166 chr1:46157942 G/A cg06784218 chr1:46089804 CCDC17 0.66 12.41 0.56 2.76e-29 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs7617480 0.648 rs4974083 chr3:49000626 A/G cg20833759 chr3:49053208 WDR6;DALRD3 0.74 11.26 0.53 4.35e-25 Subjective well-being (multi-trait analysis);Menarche (age at onset); CRC cis rs9311474 0.581 rs13621 chr3:52558133 T/C cg18099408 chr3:52552593 STAB1 -0.49 -8.58 -0.43 3.69e-16 Electroencephalogram traits; CRC cis rs9322193 0.923 rs1080670 chr6:149941297 C/G cg00933542 chr6:150070202 PCMT1 0.29 6.08 0.32 3.37e-9 Lung cancer; CRC cis rs67340775 0.541 rs169287 chr6:27854760 C/A cg03623178 chr6:28175578 NA 0.87 9.05 0.45 1.28e-17 Lung cancer in ever smokers; CRC cis rs6964587 1.000 rs6952671 chr7:91597934 C/A cg17063962 chr7:91808500 NA 0.81 14.19 0.62 5.71e-36 Breast cancer; CRC cis rs7909074 1.000 rs4948925 chr10:45392455 C/T cg05187965 chr10:45406764 TMEM72 -0.38 -8.99 -0.44 2.04e-17 Mean corpuscular volume; CRC cis rs4713118 0.547 rs2116981 chr6:28067951 T/G cg12273811 chr6:28175739 NA 0.73 9.31 0.46 1.82e-18 Parkinson's disease; CRC cis rs2645694 0.603 rs2703123 chr4:77821154 C/T cg03477792 chr4:77819574 ANKRD56 0.44 6.37 0.33 6.51e-10 Emphysema distribution in smoking; CRC cis rs6964587 1.000 rs4265 chr7:91719608 A/G cg17063962 chr7:91808500 NA -0.79 -14.21 -0.62 4.49e-36 Breast cancer; CRC cis rs12594515 0.904 rs8032875 chr15:45998010 A/C cg19682013 chr15:45996608 NA 0.32 6.6 0.34 1.6e-10 Waist circumference;Weight; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg01839850 chr22:38240395 ANKRD54;MIR658 0.51 7.26 0.37 2.87e-12 Response to antipsychotic treatment; CRC cis rs35306767 0.714 rs10508206 chr10:1075777 A/C cg26597838 chr10:835615 NA 0.67 8.7 0.43 1.61e-16 Eosinophil percentage of granulocytes; CRC cis rs8105895 0.935 rs10405613 chr19:22244772 C/T cg02657401 chr19:22469223 NA -0.34 -5.65 -0.3 3.56e-8 Body mass index (change over time); CRC cis rs3540 0.513 rs2601154 chr15:90894284 T/C cg22089800 chr15:90895588 ZNF774 0.62 10.5 0.5 1.91e-22 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; CRC cis rs2836950 0.509 rs11088466 chr21:40580017 T/A cg11644478 chr21:40555479 PSMG1 -0.48 -7.15 -0.37 5.52e-12 Menarche (age at onset); CRC cis rs2836950 0.502 rs12627205 chr21:40630027 C/T cg06238570 chr21:40685208 BRWD1 -0.6 -8.64 -0.43 2.49e-16 Menarche (age at onset); CRC cis rs10504229 1.000 rs67705655 chr8:58177688 G/A cg01721255 chr8:58191610 C8orf71 0.49 6.17 0.32 2e-9 Developmental language disorder (linguistic errors); CRC cis rs60871478 0.735 rs10950455 chr7:831451 C/T cg13798912 chr7:905769 UNC84A -0.58 -6.25 -0.33 1.24e-9 Cerebrospinal P-tau181p levels; CRC cis rs4929949 0.809 rs1900273 chr11:8483335 G/A cg17679104 chr11:8615758 STK33 -0.35 -5.74 -0.3 2.17e-8 Body mass index; CRC cis rs1712517 0.771 rs2292807 chr10:105155645 T/C cg05636881 chr10:105038444 INA 0.47 8.01 0.4 2e-14 Migraine; CRC cis rs10479542 0.721 rs6894113 chr5:178974789 G/C cg21226059 chr5:178986404 RUFY1 0.32 5.6 0.3 4.46e-8 Lung cancer; CRC cis rs2204008 0.623 rs4882302 chr12:38415608 T/A cg26384229 chr12:38710491 ALG10B -0.52 -7.49 -0.38 6.22e-13 Bladder cancer; CRC cis rs2075371 1.000 rs2598297 chr7:133993001 T/G cg11752832 chr7:134001865 SLC35B4 0.5 7.6 0.39 3.1e-13 Mean platelet volume; CRC cis rs2985684 0.894 rs6572586 chr14:50021941 A/C cg04989706 chr14:50066350 PPIL5 -0.59 -8.39 -0.42 1.44e-15 Carotid intima media thickness; CRC cis rs10504229 0.683 rs6980850 chr8:58127204 A/G cg21724239 chr8:58056113 NA 0.49 6.81 0.35 4.75e-11 Developmental language disorder (linguistic errors); CRC cis rs35264875 0.950 rs35337391 chr11:68854012 A/G cg03469862 chr11:68924853 NA 0.46 5.88 0.31 1.02e-8 Blond vs. brown hair color; CRC trans rs561341 0.769 rs9899093 chr17:30191954 C/G cg27661571 chr11:113659931 NA -0.69 -7.73 -0.39 1.3e-13 Hip circumference adjusted for BMI; CRC trans rs11148252 0.846 rs7323666 chr13:53006058 T/C cg18335740 chr13:41363409 SLC25A15 0.55 8.43 0.42 1.09e-15 Lewy body disease; CRC cis rs6952808 0.825 rs12669937 chr7:1939765 C/T cg00106254 chr7:1943704 MAD1L1 -0.51 -7.54 -0.38 4.7e-13 Bipolar disorder and schizophrenia; CRC cis rs6933660 0.745 rs6912830 chr6:151743629 A/C cg10883421 chr6:151773342 RMND1;C6orf211 0.74 13.0 0.58 1.77e-31 Menarche (age at onset); CRC cis rs1577917 0.771 rs2842613 chr6:86305702 A/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A 0.65 8.65 0.43 2.37e-16 Response to antipsychotic treatment; CRC cis rs2412819 0.542 rs62018894 chr15:43912987 C/T cg02155558 chr15:43621948 ADAL;LCMT2 0.42 5.69 0.3 2.76e-8 Lung cancer; CRC cis rs3796619 1.000 rs11247973 chr4:1094314 G/A cg11579758 chr4:1086637 RNF212 0.42 6.9 0.36 2.63e-11 Recombination rate (males); CRC cis rs6952808 0.609 rs4721185 chr7:1951109 T/C cg14004847 chr7:1930337 MAD1L1 -0.41 -6.03 -0.32 4.35e-9 Bipolar disorder and schizophrenia; CRC cis rs372883 0.583 rs117214 chr21:30720834 A/G cg24692254 chr21:30365293 RNF160 0.44 6.58 0.34 1.88e-10 Pancreatic cancer; CRC trans rs931812 1.000 rs4734494 chr8:101917721 T/C cg20993868 chr7:22813445 NA 0.42 7.95 0.4 3.1e-14 Attention deficit hyperactivity disorder and conduct disorder; CRC cis rs1448094 0.511 rs34885805 chr12:86155180 A/T cg02569458 chr12:86230093 RASSF9 0.51 8.43 0.42 1.13e-15 Major depressive disorder; CRC cis rs4332037 0.539 rs55773130 chr7:2070554 T/C cg23422044 chr7:1970798 MAD1L1 -0.55 -6.63 -0.34 1.35e-10 Bipolar disorder; CRC cis rs10504229 0.639 rs55687236 chr8:58105856 C/T cg22535103 chr8:58192502 C8orf71 -0.78 -8.39 -0.42 1.45e-15 Developmental language disorder (linguistic errors); CRC cis rs10779751 0.770 rs11581010 chr1:11212458 A/G cg08854313 chr1:11322531 MTOR -0.69 -8.15 -0.41 7.67e-15 Body mass index; CRC cis rs28386778 0.901 rs2665855 chr17:61965143 A/G cg06873352 chr17:61820015 STRADA 0.75 13.14 0.59 5.55e-32 Prudent dietary pattern; CRC cis rs13191362 1.000 rs34725898 chr6:163127302 C/T cg21926612 chr6:163149169 PACRG;PARK2 0.96 12.86 0.58 5.93e-31 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs1572438 0.831 rs17139761 chr6:856766 A/G cg21062780 chr6:887772 NA -0.34 -5.64 -0.3 3.66e-8 Aging; CRC cis rs4604732 0.527 rs7546805 chr1:247627259 G/A cg02104434 chr1:247694406 LOC148824;OR2C3 0.6 8.82 0.44 6.95e-17 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CRC cis rs9916302 0.904 rs620686 chr17:37453617 A/G cg15445000 chr17:37608096 MED1 -0.42 -9.22 -0.45 3.61e-18 Glomerular filtration rate (creatinine); CRC cis rs7618915 0.571 rs7623199 chr3:52605974 C/T cg11645453 chr3:52864694 ITIH4 0.35 6.11 0.32 2.81e-9 Bipolar disorder; CRC cis rs9527 0.590 rs6584537 chr10:104778267 C/G cg04362960 chr10:104952993 NT5C2 0.6 8.46 0.42 9.02e-16 Arsenic metabolism; CRC cis rs10905065 0.930 rs7096742 chr10:5735648 C/T cg11519256 chr10:5708881 ASB13 0.46 6.65 0.34 1.22e-10 Menopause (age at onset); CRC cis rs58688157 0.883 rs7936397 chr11:577534 G/A cg03909863 chr11:638404 DRD4 -0.4 -5.65 -0.3 3.39e-8 Systemic lupus erythematosus; CRC trans rs2303319 0.504 rs1006428 chr2:162592559 A/C cg23247704 chr1:116518985 SLC22A15 -0.72 -6.14 -0.32 2.42e-9 Cognitive function; CRC trans rs7395662 1.000 rs4882130 chr11:48588954 C/T cg21153622 chr11:89784906 NA -0.46 -7.35 -0.38 1.54e-12 HDL cholesterol; CRC cis rs9858542 0.953 rs34588335 chr3:49407660 G/C cg03060546 chr3:49711283 APEH -0.48 -6.85 -0.35 3.71e-11 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC trans rs2243480 1.000 rs316317 chr7:65613637 G/T cg10756647 chr7:56101905 PSPH 0.77 7.85 0.4 5.94e-14 Diabetic kidney disease; CRC cis rs10504229 0.728 rs55812114 chr8:58157453 C/T cg21724239 chr8:58056113 NA 0.64 8.48 0.42 8e-16 Developmental language disorder (linguistic errors); CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg17774305 chr12:50505649 C12orf62 -0.51 -6.15 -0.32 2.21e-9 Diisocyanate-induced asthma; CRC trans rs11250098 0.541 rs6997839 chr8:10766028 T/C cg08071915 chr8:12219732 FAM66A 0.35 6.11 0.32 2.75e-9 Morning vs. evening chronotype; CRC cis rs7487075 0.786 rs1492892 chr12:46691487 C/A cg22049899 chr12:47219821 SLC38A4 0.32 5.95 0.31 7.01e-9 Itch intensity from mosquito bite; CRC cis rs12580194 0.593 rs12580661 chr12:55803129 G/A cg19537932 chr12:55886519 OR6C68 -0.72 -9.16 -0.45 5.6e-18 Cancer; CRC cis rs12024301 0.557 rs6676348 chr1:183640787 T/C cg11505048 chr1:183622726 RGL1;APOBEC4 0.78 6.99 0.36 1.52e-11 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs11785693 0.862 rs11774842 chr8:4979769 A/C cg26367366 chr8:4980734 NA 0.74 9.21 0.45 4.07e-18 Neuroticism (multi-trait analysis);Neuroticism; CRC cis rs2404602 0.583 rs2139190 chr15:76555539 G/C cg22467129 chr15:76604101 ETFA -0.48 -8.56 -0.43 4.26e-16 Blood metabolite levels; CRC cis rs916888 0.773 rs199457 chr17:44795469 C/T cg17911788 chr17:44343683 NA -0.66 -7.6 -0.39 3.02e-13 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs7726839 0.574 rs11134148 chr5:637107 C/T cg09021430 chr5:549028 NA -0.73 -8.37 -0.42 1.66e-15 Obesity-related traits; CRC cis rs2153535 0.580 rs9406143 chr6:8444583 C/T cg07606381 chr6:8435919 SLC35B3 0.68 10.86 0.51 1.08e-23 Motion sickness; CRC cis rs4481887 1.000 rs10788775 chr1:248471945 C/G cg13385794 chr1:248469461 NA 0.41 7.2 0.37 4.23e-12 Common traits (Other); CRC cis rs8060686 0.920 rs73591976 chr16:67811590 C/A cg19582491 chr16:67682965 RLTPR -0.57 -6.53 -0.34 2.56e-10 HDL cholesterol;Metabolic syndrome; CRC cis rs9372498 0.536 rs62424172 chr6:118777533 C/A cg18833306 chr6:118973337 C6orf204 0.45 5.82 0.31 1.44e-8 Diastolic blood pressure; CRC cis rs892961 0.867 rs1079354 chr17:75415713 C/T cg05865280 chr17:75406074 SEPT9 0.6 13.0 0.58 1.76e-31 Airflow obstruction; CRC cis rs9837602 1.000 rs2291495 chr3:99782227 T/G cg07805332 chr3:99536008 MIR548G;C3orf26 -0.47 -6.19 -0.32 1.75e-9 Breast cancer; CRC cis rs6060717 0.536 rs11696912 chr20:34497660 C/G cg04508476 chr20:34239394 CPNE1;RBM12 0.5 5.62 0.3 4e-8 Hip circumference adjusted for BMI; CRC cis rs13256369 0.826 rs12678414 chr8:8586016 G/T cg17143192 chr8:8559678 CLDN23 0.47 6.15 0.32 2.21e-9 Obesity-related traits; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg14024356 chr1:154934173 PYGO2 0.46 6.22 0.32 1.52e-9 Response to antipsychotic treatment; CRC cis rs2404602 1.000 rs11072603 chr15:76881138 G/T cg22467129 chr15:76604101 ETFA -0.36 -6.05 -0.32 4.02e-9 Blood metabolite levels; CRC trans rs116095464 0.558 rs7730700 chr5:264713 G/A cg00938859 chr5:1591904 SDHAP3 0.73 7.89 0.4 4.53e-14 Breast cancer; CRC cis rs875971 0.755 rs10228885 chr7:65780529 C/G cg18252515 chr7:66147081 NA 0.41 5.79 0.3 1.63e-8 Aortic root size; CRC cis rs10504229 0.593 rs78459635 chr8:58004995 G/T cg22535103 chr8:58192502 C8orf71 -0.65 -7.0 -0.36 1.49e-11 Developmental language disorder (linguistic errors); CRC cis rs12188164 0.686 rs72711370 chr5:421057 A/C cg16322479 chr5:444228 EXOC3;C5orf55 0.43 6.74 0.35 7.23e-11 Cystic fibrosis severity; CRC cis rs7552404 0.727 rs2172507 chr1:76331320 A/G cg05598546 chr1:76251766 SNORD45C;RABGGTB -0.53 -6.05 -0.32 3.98e-9 Blood metabolite levels;Acylcarnitine levels; CRC trans rs9650657 0.571 rs11783247 chr8:10788875 C/T cg06636001 chr8:8085503 FLJ10661 -0.6 -8.91 -0.44 3.52e-17 Neuroticism; CRC cis rs56283067 0.887 rs9463043 chr6:44771114 T/C cg18551225 chr6:44695536 NA -0.43 -5.82 -0.31 1.37e-8 Total body bone mineral density; CRC cis rs4970966 1.000 rs4970966 chr1:150584103 A/C cg17724175 chr1:150552817 MCL1 0.5 6.19 0.32 1.78e-9 Granulocyte percentage of myeloid white cells;Monocyte count;Monocyte percentage of white cells; CRC cis rs1559088 0.803 rs10405770 chr19:33616549 C/T cg27124370 chr19:33622961 WDR88 0.42 5.81 0.31 1.45e-8 Bone ultrasound measurement (broadband ultrasound attenuation); CRC trans rs925098 0.577 rs2724470 chr4:17996046 A/G cg27563668 chr14:103995759 TRMT61A -0.42 -5.97 -0.31 6.07e-9 Birth weight;Height; CRC cis rs28386778 0.897 rs9912557 chr17:61784963 C/A cg11494091 chr17:61959527 GH2 0.62 10.53 0.5 1.6e-22 Prudent dietary pattern; CRC cis rs7811142 0.887 rs4074838 chr7:100032665 G/A cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.63 8.1 0.41 1.1e-14 Platelet count; CRC cis rs4148883 0.645 rs1154404 chr4:100009004 A/T cg13256891 chr4:100009986 ADH5 0.46 6.45 0.34 3.89e-10 Alcohol dependence; CRC cis rs6500395 0.926 rs1039343 chr16:48577507 T/G cg04672837 chr16:48644449 N4BP1 0.44 6.57 0.34 1.99e-10 Response to tocilizumab in rheumatoid arthritis; CRC trans rs9858542 1.000 rs13316695 chr3:49684917 C/G cg21659725 chr3:3221576 CRBN -0.71 -9.51 -0.46 4.13e-19 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs597539 0.652 rs559032 chr11:68710847 G/T cg04772025 chr11:68637568 NA 0.47 7.18 0.37 4.8e-12 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs853679 0.517 rs4713144 chr6:28106790 C/G cg15845792 chr6:28175446 NA 1.01 13.54 0.6 1.59e-33 Depression; CRC cis rs2732480 0.500 rs2450989 chr12:48653408 A/G cg04545296 chr12:48745243 ZNF641 -0.33 -5.73 -0.3 2.25e-8 Hemoglobin concentration;Red blood cell count;Hematocrit; CRC cis rs2204008 0.774 rs11514062 chr12:38332297 A/C cg13010199 chr12:38710504 ALG10B 0.47 6.49 0.34 3.08e-10 Bladder cancer; CRC cis rs2153904 1.000 rs2153904 chr1:205642790 A/C cg23034840 chr1:205782522 SLC41A1 0.43 5.61 0.3 4.4e-8 Prostate-specific antigen levels; CRC cis rs3858526 0.523 rs10838750 chr11:5886246 C/T cg26762873 chr11:5879799 OR52E8 0.48 7.39 0.38 1.2e-12 DNA methylation (variation); CRC cis rs10197940 0.510 rs7557092 chr2:152423459 T/A cg19508488 chr2:152266495 RIF1 0.52 6.49 0.34 3.15e-10 Lung cancer; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg25195193 chr3:195716626 SDHAP1 0.44 6.04 0.32 4.15e-9 Anxiety disorder; CRC cis rs7208859 0.673 rs56146117 chr17:29153325 C/T cg01831904 chr17:28903510 LRRC37B2 -0.61 -6.39 -0.33 5.68e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs427941 0.703 rs201457 chr7:101741338 C/A cg06246474 chr7:101738831 CUX1 0.46 7.24 0.37 3.2e-12 Plasma omega-3 polyunsaturated fatty acid level (eicosapentaenoic acid); CRC trans rs7824557 0.606 rs2736264 chr8:11186639 G/C cg06636001 chr8:8085503 FLJ10661 0.45 6.54 0.34 2.33e-10 Retinal vascular caliber; CRC cis rs7618915 0.531 rs77146033 chr3:52701501 G/T cg18404041 chr3:52824283 ITIH1 -0.43 -8.73 -0.43 1.3e-16 Bipolar disorder; CRC cis rs9611565 0.512 rs2899349 chr22:42164660 T/C cg06634786 chr22:41940651 POLR3H 0.66 7.3 0.37 2.18e-12 Vitiligo; CRC cis rs7208859 0.573 rs216442 chr17:28931197 T/G cg01831904 chr17:28903510 LRRC37B2 -0.58 -5.94 -0.31 7.45e-9 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs7909074 0.651 rs10900127 chr10:45390103 C/A cg04218760 chr10:45406644 TMEM72 -0.27 -7.15 -0.37 5.73e-12 Mean corpuscular volume; CRC cis rs7945705 0.747 rs2568020 chr11:8994715 C/T cg12365402 chr11:9010492 NRIP3 -0.61 -11.47 -0.53 7.76e-26 Hemoglobin concentration; CRC cis rs35110281 0.633 rs4819289 chr21:45120237 A/G cg04455712 chr21:45112962 RRP1B 0.39 7.41 0.38 1.07e-12 Mean corpuscular volume; CRC cis rs12135062 0.851 rs2651926 chr1:3101820 C/T cg00254258 chr1:3105189 PRDM16 -0.55 -9.35 -0.46 1.43e-18 Migraine; CRC cis rs9388451 0.839 rs1811852 chr6:126071575 G/C cg05901451 chr6:126070800 HEY2 -0.68 -12.02 -0.55 7.44e-28 Brugada syndrome; CRC cis rs651907 0.535 rs17347156 chr3:101504674 G/A cg11279151 chr3:101281821 RG9MTD1 -0.51 -6.87 -0.35 3.29e-11 Colorectal cancer; CRC cis rs7191700 0.578 rs243327 chr16:11353304 C/T cg00044050 chr16:11439710 C16orf75 -0.53 -7.64 -0.39 2.46e-13 Multiple sclerosis; CRC cis rs4975709 0.610 rs4975704 chr5:1859807 C/A cg20790798 chr5:1857306 NA -0.44 -6.66 -0.34 1.12e-10 Cardiovascular disease risk factors; CRC cis rs6502050 0.835 rs8065565 chr17:80115399 A/G cg09264619 chr17:80180166 NA -0.35 -5.97 -0.31 5.98e-9 Life satisfaction; CRC cis rs8060686 0.545 rs76495028 chr16:68177036 G/C cg26727032 chr16:67993705 SLC12A4 -0.57 -5.84 -0.31 1.29e-8 HDL cholesterol;Metabolic syndrome; CRC cis rs2463822 1.000 rs72921501 chr11:62115622 A/T cg06239285 chr11:62104954 ASRGL1 -1.01 -10.71 -0.51 3.79e-23 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs9868809 0.764 rs41290686 chr3:48604059 G/A cg00383909 chr3:49044727 WDR6 1.13 7.77 0.39 1.04e-13 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; CRC trans rs10875746 0.859 rs12305647 chr12:48582961 T/C cg16281234 chr15:35388805 NA -0.51 -6.45 -0.34 4.08e-10 Longevity (90 years and older); CRC cis rs1223397 0.938 rs3817742 chr6:13279552 T/C cg06879394 chr6:13274151 PHACTR1 0.51 6.13 0.32 2.5e-9 Blood pressure; CRC cis rs9595066 1.000 rs7981575 chr13:44710947 C/T cg04068111 chr13:44716778 NA -0.44 -6.11 -0.32 2.82e-9 Schizophrenia; CRC cis rs875971 0.638 rs6960778 chr7:66071597 C/T cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.45 -6.57 -0.34 1.91e-10 Aortic root size; CRC cis rs4862750 0.872 rs7658314 chr4:187900356 T/C cg03647317 chr4:187891568 NA -0.54 -10.28 -0.49 1.09e-21 Lobe attachment (rater-scored or self-reported); CRC cis rs1448094 0.549 rs57614821 chr12:86235361 A/C cg18827107 chr12:86230957 RASSF9 -0.5 -8.13 -0.41 8.79e-15 Major depressive disorder; CRC cis rs2658782 0.951 rs72972357 chr11:93118840 T/C cg15737290 chr11:93063684 CCDC67 -0.52 -7.36 -0.38 1.49e-12 Pulmonary function decline; CRC cis rs10751667 0.643 rs10794350 chr11:946070 A/G ch.11.42038R chr11:967971 AP2A2 0.59 10.15 0.49 3e-21 Alzheimer's disease (late onset); CRC cis rs846111 1.000 rs846111 chr1:6279370 G/C cg02892189 chr1:6321676 GPR153 -0.64 -7.83 -0.4 6.64e-14 QT interval; CRC cis rs7647973 0.626 rs1586827 chr3:49671224 T/C cg03060546 chr3:49711283 APEH 0.66 7.96 0.4 2.73e-14 Menarche (age at onset); CRC cis rs7264396 0.790 rs2425096 chr20:34308588 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.64 -10.89 -0.51 8.94e-24 Total cholesterol levels; CRC trans rs747782 0.582 rs7949865 chr11:48346202 A/C cg15704280 chr7:45808275 SEPT13 -0.69 -6.68 -0.35 1.03e-10 Intraocular pressure; CRC trans rs2962250 0.660 rs62368778 chr5:50346354 C/T cg07611666 chr18:74729481 MBP -0.62 -6.0 -0.31 5.2e-9 Schizophrenia; CRC cis rs7208859 0.673 rs9899943 chr17:29223925 G/A cg01831904 chr17:28903510 LRRC37B2 -0.56 -5.83 -0.31 1.35e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs11098499 0.909 rs7659501 chr4:120371552 G/T cg09307838 chr4:120376055 NA 0.72 11.14 0.52 1.1e-24 Corneal astigmatism; CRC cis rs9948 0.655 rs62156216 chr2:97405127 C/T cg20312557 chr2:97357134 FER1L5 -0.6 -5.61 -0.3 4.38e-8 Erectile dysfunction and prostate cancer treatment; CRC cis rs72615157 0.634 rs79986079 chr7:99802044 C/T cg07160278 chr7:100027354 MEPCE;ZCWPW1 0.72 8.63 0.43 2.75e-16 Lung function (FEV1/FVC); CRC cis rs11122272 0.701 rs2491402 chr1:231494338 T/C cg06096015 chr1:231504339 EGLN1 0.41 6.27 0.33 1.15e-9 Hemoglobin concentration; CRC trans rs2303319 0.504 rs12470830 chr2:162429996 C/T cg01422129 chr2:677375 TMEM18 -0.74 -6.01 -0.31 4.85e-9 Cognitive function; CRC cis rs3849570 0.615 rs6778265 chr3:81985745 C/T cg07356753 chr3:81810745 GBE1 0.47 6.36 0.33 6.74e-10 Waist circumference;Body mass index; CRC cis rs9322193 0.923 rs10782315 chr6:150064229 T/C cg00933542 chr6:150070202 PCMT1 0.32 6.57 0.34 1.94e-10 Lung cancer; CRC cis rs13108904 0.870 rs4974545 chr4:1271923 C/T cg00684032 chr4:1343700 KIAA1530 0.47 6.92 0.36 2.34e-11 Obesity-related traits; CRC cis rs4523957 0.928 rs12943566 chr17:2157774 A/G cg16513277 chr17:2031491 SMG6 0.53 8.66 0.43 2.2e-16 Autism spectrum disorder or schizophrenia;Schizophrenia; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg00454932 chr1:171750547 METTL13 0.45 6.12 0.32 2.65e-9 Anxiety disorder; CRC cis rs875971 0.617 rs810400 chr7:66022889 G/C cg11764359 chr7:65958608 NA -0.55 -8.6 -0.43 3.21e-16 Aortic root size; CRC cis rs28386778 0.897 rs6504184 chr17:61842408 A/T cg06601766 chr17:61851465 DDX42;CCDC47 0.45 6.1 0.32 3.06e-9 Prudent dietary pattern; CRC cis rs6662572 0.737 rs4388641 chr1:46522326 A/C cg03123370 chr1:45965343 CCDC163P;MMACHC 0.47 6.17 0.32 1.97e-9 Blood protein levels; CRC cis rs1799949 1.000 rs2271573 chr17:41327621 A/G cg23758822 chr17:41437982 NA 0.81 13.48 0.6 2.7e-33 Menopause (age at onset); CRC trans rs61931739 0.500 rs3934517 chr12:34451396 T/C cg26384229 chr12:38710491 ALG10B 0.62 9.11 0.45 8.27e-18 Morning vs. evening chronotype; CRC cis rs6938 0.534 rs11636892 chr15:75266049 G/C cg14664628 chr15:75095509 CSK -0.53 -7.61 -0.39 2.9e-13 Breast cancer; CRC cis rs4654899 0.897 rs12121807 chr1:21069129 A/C cg02927042 chr1:21476669 EIF4G3 -0.43 -6.7 -0.35 9.13e-11 Superior frontal gyrus grey matter volume; CRC cis rs6951245 1.000 rs6951245 chr7:1058193 G/A cg03188948 chr7:1209495 NA 0.58 6.03 0.32 4.47e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs7932354 0.528 rs7947878 chr11:47028531 C/T cg19486271 chr11:47235900 DDB2 -0.44 -6.53 -0.34 2.43e-10 Bone mineral density (hip);Bone mineral density; CRC cis rs3790645 1.000 rs35245195 chr1:26884039 C/G cg23229016 chr1:26872525 RPS6KA1 0.31 7.22 0.37 3.6e-12 Glucose homeostasis traits; CRC cis rs7605827 0.930 rs3755129 chr2:15523549 T/C cg19274914 chr2:15703543 NA 0.39 5.9 0.31 8.92e-9 Educational attainment (years of education); CRC cis rs10504229 0.638 rs6981055 chr8:58113941 T/C cg02725872 chr8:58115012 NA -0.65 -11.61 -0.54 2.34e-26 Developmental language disorder (linguistic errors); CRC cis rs919433 1.000 rs112572902 chr2:198175179 G/C cg20885578 chr2:198174922 NA -0.41 -7.42 -0.38 1.04e-12 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC cis rs2303745 0.544 rs12710308 chr19:17395879 T/A cg27101125 chr19:17392770 ANKLE1 -0.33 -5.81 -0.3 1.5e-8 Systemic lupus erythematosus; CRC cis rs7086803 1.000 rs7085406 chr10:114503496 G/C cg03281572 chr10:114502318 VTI1A 0.75 6.34 0.33 7.77e-10 Lung cancer; CRC cis rs4319547 0.695 rs4758648 chr12:122900460 A/G cg05707623 chr12:122985044 ZCCHC8 -0.6 -7.59 -0.39 3.39e-13 Body mass index; CRC cis rs1712517 0.526 rs113528138 chr10:105125451 C/A cg04362960 chr10:104952993 NT5C2 -0.44 -5.71 -0.3 2.51e-8 Migraine; CRC cis rs473651 0.901 rs563282 chr2:239329736 T/C cg08773314 chr2:239334832 ASB1 0.36 7.98 0.4 2.43e-14 Multiple system atrophy; CRC cis rs9303401 0.538 rs35454383 chr17:56475599 C/T cg10487724 chr17:56770010 TEX14;RAD51C 0.71 8.01 0.4 1.97e-14 Cognitive test performance; CRC cis rs4730250 0.670 rs9641380 chr7:106868151 C/G cg02696742 chr7:106810147 HBP1 -0.61 -6.92 -0.36 2.41e-11 Osteoarthritis; CRC cis rs4713118 0.955 rs9468206 chr6:27690453 G/T cg06470822 chr6:28175283 NA 0.68 9.12 0.45 7.67e-18 Parkinson's disease; CRC cis rs4808199 0.948 rs2074301 chr19:19381715 G/A cg03709012 chr19:19516395 GATAD2A 0.99 11.89 0.55 2.31e-27 Nonalcoholic fatty liver disease; CRC trans rs7179994 0.579 rs72712674 chr15:28300248 T/C cg05237436 chr5:138533428 SIL1 0.7 6.28 0.33 1.1e-9 Shingles; CRC cis rs4728302 0.869 rs6969899 chr7:133597490 A/G cg10665199 chr7:133106180 EXOC4 0.37 5.62 0.3 4.01e-8 Intelligence;Intelligence (multi-trait analysis); CRC cis rs853679 0.598 rs9380054 chr6:28067537 G/A cg02631126 chr6:28058918 ZSCAN12L1 0.3 6.11 0.32 2.83e-9 Depression; CRC cis rs12701220 0.553 rs9639882 chr7:1133731 G/A cg26769984 chr7:1090371 C7orf50 0.5 6.86 0.35 3.39e-11 Bronchopulmonary dysplasia; CRC trans rs12517041 1.000 rs4701364 chr5:23301087 C/A ch.8.1293020R chr8:59333349 UBXN2B -0.55 -6.12 -0.32 2.66e-9 Calcium levels; CRC cis rs4237845 0.837 rs7963992 chr12:58295949 G/C cg00677455 chr12:58241039 CTDSP2 0.53 8.0 0.4 2.19e-14 Intelligence (multi-trait analysis); CRC cis rs9894429 1.000 rs7223613 chr17:79574803 C/T cg13777783 chr17:79615861 NA 0.3 5.72 0.3 2.44e-8 Eye color traits; CRC cis rs78456975 1.000 rs6744743 chr2:1558161 C/T cg12573674 chr2:1569213 NA 0.74 7.82 0.4 7.32e-14 Placebo response in major depressive disorder (% change in symptom score); CRC cis rs6912958 0.500 rs3828759 chr6:87806640 T/C cg04972856 chr6:88032051 C6orf162;GJB7 -0.32 -5.69 -0.3 2.84e-8 Monocyte percentage of white cells; CRC cis rs875971 0.545 rs2279757 chr7:65828663 T/C cg18876405 chr7:65276391 NA 0.47 6.41 0.33 5.04e-10 Aortic root size; CRC cis rs34779708 0.931 rs4934697 chr10:35287192 C/T cg03585969 chr10:35415529 CREM 0.66 8.8 0.44 7.91e-17 Inflammatory bowel disease;Crohn's disease; CRC cis rs172166 0.516 rs1150670 chr6:28130559 A/G cg12273811 chr6:28175739 NA 0.46 6.93 0.36 2.18e-11 Cardiac Troponin-T levels; CRC cis rs9522267 0.535 rs12583489 chr13:112233455 G/A cg10483660 chr13:112241077 NA -0.48 -8.98 -0.44 2.09e-17 Hepatitis; CRC trans rs4276421 0.776 rs7723380 chr5:45428535 T/C cg04793272 chr11:119020941 ABCG4 -0.38 -6.22 -0.32 1.51e-9 P wave duration; CRC cis rs4975616 0.869 rs421284 chr5:1325590 T/C cg06550200 chr5:1325588 CLPTM1L -0.75 -12.21 -0.56 1.61e-28 Lung cancer; CRC cis rs7618501 0.633 rs9866695 chr3:50069452 G/T cg24110177 chr3:50126178 RBM5 0.46 6.89 0.36 2.79e-11 Intelligence (multi-trait analysis); CRC cis rs7927592 0.956 rs12277225 chr11:68340967 T/C cg01657329 chr11:68192670 LRP5 -0.48 -6.94 -0.36 2.07e-11 Total body bone mineral density; CRC cis rs853679 0.517 rs1947863 chr6:28099344 G/A cg15786705 chr6:28176104 NA 0.77 9.75 0.47 6.92e-20 Depression; CRC cis rs1707322 1.000 rs946527 chr1:46485970 C/T cg03146154 chr1:46216737 IPP 0.52 7.29 0.37 2.3e-12 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs6570726 0.791 rs400329 chr6:145879442 A/T cg23711669 chr6:146136114 FBXO30 0.77 13.41 0.59 5.08e-33 Lobe attachment (rater-scored or self-reported); CRC cis rs2692947 0.683 rs2315416 chr2:96558477 C/T cg22654517 chr2:96458247 NA 0.32 5.72 0.3 2.43e-8 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; CRC cis rs3749237 0.595 rs4855877 chr3:49448527 T/C cg03060546 chr3:49711283 APEH 0.6 10.25 0.49 1.36e-21 Resting heart rate; CRC cis rs10876993 0.928 rs774890 chr12:58068388 C/T cg15848620 chr12:58087721 OS9 -0.62 -8.73 -0.43 1.32e-16 Celiac disease or Rheumatoid arthritis; CRC cis rs9910055 0.531 rs6503490 chr17:42246656 A/G cg19774624 chr17:42201019 HDAC5 -0.72 -11.78 -0.54 5.93e-27 Total body bone mineral density; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg09188016 chr12:64798414 XPOT 0.42 6.87 0.35 3.17e-11 Liver disease severity in Alagille syndrome; CRC cis rs7586879 0.828 rs11685125 chr2:25092104 A/G cg22495460 chr2:25135724 ADCY3 -0.83 -13.9 -0.61 7.3e-35 Body mass index; CRC cis rs17001868 0.568 rs2075764 chr22:40758581 C/T cg07138101 chr22:40742427 ADSL 0.55 6.8 0.35 4.92e-11 Mammographic density (dense area); CRC cis rs17818399 0.547 rs35178974 chr2:46763898 T/C cg26688816 chr2:46740690 ATP6V1E2 -0.51 -6.47 -0.34 3.5e-10 Height; CRC cis rs3820068 0.705 rs4646110 chr1:15817318 A/T cg27534772 chr1:16042836 PLEKHM2 0.37 6.2 0.32 1.67e-9 Systolic blood pressure; CRC cis rs9487051 0.676 rs6568560 chr6:109592851 G/A cg21918786 chr6:109611834 NA -0.42 -7.46 -0.38 7.91e-13 Reticulocyte fraction of red cells; CRC cis rs7264396 0.563 rs2050729 chr20:34294409 A/G cg04508476 chr20:34239394 CPNE1;RBM12 0.48 6.5 0.34 2.99e-10 Total cholesterol levels; CRC cis rs853679 0.517 rs9393890 chr6:28063855 C/T cg03623178 chr6:28175578 NA 0.95 12.46 0.57 1.93e-29 Depression; CRC cis rs7927771 1.000 rs12421210 chr11:47779586 C/T cg05585544 chr11:47624801 NA -0.62 -10.82 -0.51 1.47e-23 Subjective well-being; CRC cis rs7208859 0.623 rs11657369 chr17:29136468 G/A cg01831904 chr17:28903510 LRRC37B2 -0.62 -6.41 -0.33 5.13e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs9311474 0.597 rs13303 chr3:52558008 T/C cg05573699 chr3:52720067 GNL3;PBRM1 -0.43 -6.43 -0.33 4.49e-10 Electroencephalogram traits; CRC cis rs9467711 0.591 rs35169013 chr6:25918027 A/C cg08501292 chr6:25962987 TRIM38 1.08 9.72 0.47 8.61e-20 Autism spectrum disorder or schizophrenia; CRC cis rs4930103 0.935 rs2075744 chr11:2018449 A/G cg23202291 chr11:1979235 NA 0.47 6.57 0.34 1.99e-10 DNA methylation (parent-of-origin);DNA methylation (variation); CRC cis rs2976388 1.000 rs2920292 chr8:143765699 A/G cg24046110 chr8:143859143 LYNX1 -0.38 -6.6 -0.34 1.65e-10 Urinary tract infection frequency; CRC cis rs2303745 0.589 rs10401700 chr19:17397700 A/C cg15110403 chr19:17392923 ANKLE1 -0.36 -6.26 -0.33 1.21e-9 Systemic lupus erythematosus; CRC cis rs6968419 0.747 rs3779509 chr7:115864889 C/A cg02561103 chr7:115862891 TES -0.43 -6.45 -0.33 4.1e-10 Intraocular pressure; CRC cis rs3733585 0.673 rs6840802 chr4:9965633 C/G cg11266682 chr4:10021025 SLC2A9 0.46 9.14 0.45 6.48e-18 Cleft plate (environmental tobacco smoke interaction); CRC cis rs372883 0.600 rs1236460 chr21:30615513 G/A cg08807101 chr21:30365312 RNF160 -0.59 -8.16 -0.41 7.18e-15 Pancreatic cancer; CRC cis rs9435341 0.965 rs1762482 chr1:107599002 A/C cg09367891 chr1:107599246 PRMT6 -0.64 -9.75 -0.47 6.97e-20 Facial morphology (factor 21, depth of nasal alae); CRC cis rs9323205 0.834 rs12434435 chr14:51667524 G/T cg23942311 chr14:51606299 NA 0.59 8.29 0.42 2.97e-15 Cancer; CRC cis rs2576037 0.583 rs8096263 chr18:44515216 C/T cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.55 -8.23 -0.41 4.39e-15 Personality dimensions; CRC cis rs853679 0.517 rs9380060 chr6:28132603 G/A cg15845792 chr6:28175446 NA 1.04 13.89 0.61 7.67e-35 Depression; CRC trans rs11098499 0.954 rs1022145 chr4:120230979 A/G cg25214090 chr10:38739885 LOC399744 0.6 9.1 0.45 8.82e-18 Corneal astigmatism; CRC cis rs1322512 1.000 rs2250632 chr6:153011126 C/A cg03415253 chr6:152958462 SYNE1 0.42 6.47 0.34 3.47e-10 Tonometry; CRC cis rs11155671 0.530 rs7757984 chr6:150208651 A/G cg13206674 chr6:150067644 NUP43 0.48 6.88 0.35 2.98e-11 Testicular germ cell tumor; CRC cis rs9527 0.525 rs12770034 chr10:104635595 A/G cg15744005 chr10:104629667 AS3MT -0.38 -7.69 -0.39 1.72e-13 Arsenic metabolism; CRC trans rs11098499 0.754 rs10006259 chr4:120242145 C/T cg25214090 chr10:38739885 LOC399744 0.53 8.36 0.42 1.78e-15 Corneal astigmatism; CRC cis rs9322817 0.691 rs2290515 chr6:105232204 C/T cg02098413 chr6:105308735 HACE1 -0.44 -8.55 -0.43 4.67e-16 Thyroid stimulating hormone; CRC cis rs10504229 0.683 rs66730544 chr8:58127280 A/T cg02290350 chr8:58132656 NA -0.58 -8.16 -0.41 7.29e-15 Developmental language disorder (linguistic errors); CRC cis rs6564851 0.506 rs56353925 chr16:81258368 A/G cg05274606 chr16:81253692 PKD1L2 -0.35 -5.66 -0.3 3.32e-8 Carotenoid and tocopherol levels; CRC trans rs16846053 0.792 rs55893794 chr2:162418751 G/A cg09481857 chr22:21368659 P2RX6;MGC16703 -0.64 -6.1 -0.32 3.04e-9 Blood osmolality (transformed sodium); CRC trans rs10982213 0.830 rs2274163 chr9:117188714 C/T cg08056012 chr3:130612679 ATP2C1 0.39 6.05 0.32 4.02e-9 Interleukin-6 levels; CRC cis rs11677416 1.000 rs4848304 chr2:113552737 T/C cg27083787 chr2:113543245 IL1A 0.46 6.26 0.33 1.22e-9 Response to antipsychotic treatment in schizophrenia (working memory); CRC cis rs9859260 0.710 rs41298097 chr3:195779155 C/T cg12923728 chr3:195709715 SDHAP1 0.48 6.54 0.34 2.35e-10 Mean corpuscular volume; CRC cis rs10782582 0.593 rs12129523 chr1:76129223 C/A cg03433033 chr1:76189801 ACADM -0.42 -6.1 -0.32 2.94e-9 Daytime sleep phenotypes; CRC cis rs4760636 0.648 rs12810487 chr12:48159571 T/C cg13326926 chr12:48153388 RAPGEF3 0.6 5.98 0.31 5.66e-9 Urate levels; CRC cis rs747650 0.504 rs4269876 chr11:47109463 T/A cg19486271 chr11:47235900 DDB2 0.44 5.89 0.31 9.76e-9 Acne (severe); CRC cis rs3820068 0.580 rs12746773 chr1:16001588 C/T cg13390004 chr1:15929781 NA 0.5 6.91 0.36 2.53e-11 Systolic blood pressure; CRC cis rs6963495 0.818 rs116845562 chr7:105217038 T/C cg02135003 chr7:105160482 PUS7 -0.91 -11.94 -0.55 1.58e-27 Bipolar disorder (body mass index interaction); CRC cis rs4690686 0.500 rs7657249 chr4:177275198 A/G cg17059388 chr4:177262070 NA 0.39 5.84 0.31 1.25e-8 Essential tremor; CRC cis rs9322193 0.962 rs3763162 chr6:150140810 A/G cg07701084 chr6:150067640 NUP43 -0.47 -6.5 -0.34 2.89e-10 Lung cancer; CRC cis rs10905065 0.965 rs10752110 chr10:5837038 T/C cg11519256 chr10:5708881 ASB13 0.51 7.6 0.39 3.17e-13 Menopause (age at onset); CRC cis rs832540 0.866 rs832579 chr5:56164943 A/G cg12311346 chr5:56204834 C5orf35 -0.47 -6.98 -0.36 1.61e-11 Coronary artery disease; CRC cis rs7932354 0.528 rs1872896 chr11:47160623 C/T cg19486271 chr11:47235900 DDB2 -0.47 -7.13 -0.37 6.33e-12 Bone mineral density (hip);Bone mineral density; CRC cis rs4243830 0.737 rs925744 chr1:6615695 C/T cg05709478 chr1:6581295 PLEKHG5 -0.55 -6.59 -0.34 1.76e-10 Body mass index; CRC cis rs875971 0.895 rs4718349 chr7:65909011 C/G cg11764359 chr7:65958608 NA 0.62 9.91 0.48 1.96e-20 Aortic root size; CRC cis rs2153535 0.580 rs4960413 chr6:8438466 C/T cg07606381 chr6:8435919 SLC35B3 0.68 10.89 0.51 8.99e-24 Motion sickness; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg19307233 chr1:231377017 C1orf131;GNPAT 0.46 6.39 0.33 5.79e-10 Anxiety disorder; CRC cis rs11122272 0.735 rs2790883 chr1:231532726 A/G cg06096015 chr1:231504339 EGLN1 0.4 5.98 0.31 5.97e-9 Hemoglobin concentration; CRC cis rs7937682 0.961 rs7119563 chr11:111543916 T/A cg19812747 chr11:111475976 SIK2 0.51 8.07 0.41 1.34e-14 Primary sclerosing cholangitis; CRC cis rs4588572 0.643 rs1864172 chr5:77690945 T/C cg11446398 chr5:77624930 NA -0.47 -6.55 -0.34 2.15e-10 Triglycerides; CRC cis rs6460942 0.915 rs6965564 chr7:12306013 C/T cg20607287 chr7:12443886 VWDE -0.47 -6.11 -0.32 2.85e-9 Coronary artery disease; CRC trans rs8005745 0.505 rs710047 chr14:62118819 C/G cg21461308 chr16:87754019 KLHDC4 -0.45 -6.34 -0.33 7.39e-10 Select biomarker traits; CRC cis rs68170813 0.605 rs10464620 chr7:107135653 A/G cg02696742 chr7:106810147 HBP1 0.59 6.31 0.33 9.06e-10 Coronary artery disease; CRC cis rs10499694 0.901 rs6975453 chr7:50585211 A/T cg18232548 chr7:50535776 DDC -0.4 -6.12 -0.32 2.64e-9 Body mass index; CRC cis rs992157 0.560 rs6436047 chr2:219108913 A/C cg00012203 chr2:219082015 ARPC2 0.53 8.4 0.42 1.31e-15 Colorectal cancer; CRC cis rs9916302 0.861 rs752314 chr17:37410700 C/T cg00129232 chr17:37814104 STARD3 -0.53 -7.89 -0.4 4.57e-14 Glomerular filtration rate (creatinine); CRC cis rs2836974 0.644 rs61300849 chr21:40680194 G/A cg11890956 chr21:40555474 PSMG1 -0.9 -15.26 -0.64 3.95e-40 Cognitive function; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg00776160 chr1:149815087 HIST2H2AA3;HIST2H2AA4 0.49 6.86 0.35 3.53e-11 Response to antipsychotic treatment; CRC cis rs3764400 0.508 rs12601350 chr17:46120419 T/C cg10706073 chr17:46328419 SKAP1 -0.68 -7.28 -0.37 2.53e-12 Body mass index; CRC cis rs2404602 0.735 rs11857015 chr15:76649390 T/C cg03037974 chr15:76606532 NA -0.49 -7.16 -0.37 5.34e-12 Blood metabolite levels; CRC cis rs7799006 0.929 rs71525363 chr7:2268792 G/A cg08027265 chr7:2291960 NA -0.4 -6.12 -0.32 2.59e-9 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs10504229 0.639 rs2318145 chr8:58114867 A/G cg02290350 chr8:58132656 NA -0.58 -8.24 -0.41 4.09e-15 Developmental language disorder (linguistic errors); CRC cis rs1799949 0.965 rs33961729 chr17:41287924 C/A cg01879757 chr17:41196368 BRCA1 -0.42 -6.24 -0.33 1.31e-9 Menopause (age at onset); CRC cis rs8105895 0.935 rs8104144 chr19:22246913 T/C cg02657401 chr19:22469223 NA -0.34 -5.65 -0.3 3.56e-8 Body mass index (change over time); CRC cis rs826838 0.559 rs4882276 chr12:38611994 T/C cg26384229 chr12:38710491 ALG10B 0.43 6.25 0.33 1.26e-9 Heart rate; CRC cis rs425277 0.606 rs424079 chr1:2071340 C/A cg24578937 chr1:2090814 PRKCZ -0.39 -7.11 -0.36 7.27e-12 Height; CRC cis rs7215564 0.908 rs7501544 chr17:78660946 T/A cg09596252 chr17:78655493 RPTOR 0.54 5.73 0.3 2.25e-8 Myopia (pathological); CRC cis rs1355223 0.966 rs11602318 chr11:34766983 C/T cg11058730 chr11:34937778 PDHX;APIP 0.45 6.3 0.33 9.59e-10 Systemic lupus erythematosus and Systemic sclerosis; CRC cis rs10924970 0.870 rs2382569 chr1:235469032 A/G cg26050004 chr1:235667680 B3GALNT2 0.4 6.0 0.31 5.32e-9 Asthma; CRC cis rs561341 0.883 rs7406056 chr17:30220224 C/T cg12193833 chr17:30244370 NA -0.61 -7.36 -0.38 1.5e-12 Hip circumference adjusted for BMI; CRC cis rs4665809 1.000 rs4233709 chr2:26291493 C/T cg04944784 chr2:26401820 FAM59B 0.56 7.26 0.37 2.84e-12 Gut microbiome composition (summer); CRC cis rs9807989 0.507 rs6734762 chr2:103062926 C/T cg03938978 chr2:103052716 IL18RAP 0.58 10.22 0.49 1.73e-21 Asthma; CRC cis rs9660180 0.836 rs72634845 chr1:1704899 G/A cg13866156 chr1:1669148 SLC35E2 -0.64 -9.86 -0.48 3e-20 Body mass index; CRC cis rs728616 0.867 rs61860412 chr10:81728486 G/A cg05935833 chr10:81318306 SFTPA2 -0.73 -8.0 -0.4 2.14e-14 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs10979 0.557 rs9403517 chr6:143909400 T/C cg25407410 chr6:143891975 LOC285740 -0.66 -8.82 -0.44 6.63e-17 Hypospadias; CRC cis rs12913538 0.641 rs12591920 chr15:62902495 A/C cg09983546 chr15:62884068 NA -0.52 -7.87 -0.4 5.33e-14 Sleep depth; CRC cis rs9388451 0.626 rs3734637 chr6:126081319 G/T cg05901451 chr6:126070800 HEY2 -0.52 -8.73 -0.43 1.34e-16 Brugada syndrome; CRC cis rs9926296 0.585 rs1800337 chr16:89845194 A/G cg27121462 chr16:89883253 FANCA 0.59 9.4 0.46 9.55e-19 Vitiligo; CRC cis rs924607 1.000 rs12523022 chr5:598643 C/T cg09021430 chr5:549028 NA 0.53 8.94 0.44 2.94e-17 Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia; CRC cis rs6546550 0.935 rs4241261 chr2:70063660 A/G cg02498382 chr2:70120550 SNRNP27 -0.46 -7.48 -0.38 6.75e-13 Prevalent atrial fibrillation; CRC cis rs35306767 0.903 rs7067865 chr10:908387 C/T cg20503657 chr10:835505 NA 0.97 12.22 0.56 1.49e-28 Eosinophil percentage of granulocytes; CRC trans rs9329221 0.905 rs28712068 chr8:10251145 G/C cg16141378 chr3:129829833 LOC729375 0.44 6.75 0.35 6.61e-11 Neuroticism; CRC cis rs6752107 1.000 rs13009506 chr2:234175706 A/C cg07618928 chr2:234183455 ATG16L1;SCARNA5 -0.64 -11.02 -0.52 3.14e-24 Crohn's disease;Inflammatory bowel disease; CRC cis rs6539288 0.630 rs1055332 chr12:107348625 T/A cg13491945 chr12:107078410 RFX4 0.34 5.67 0.3 3.16e-8 Total body bone mineral density; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg01357671 chr17:3626806 ITGAE;GSG2 0.42 6.18 0.32 1.9e-9 Intelligence (multi-trait analysis); CRC cis rs7666738 0.830 rs28729647 chr4:99059552 T/C cg05340658 chr4:99064831 C4orf37 0.6 9.26 0.45 2.82e-18 Colonoscopy-negative controls vs population controls; CRC cis rs4689388 0.890 rs4688989 chr4:6290594 T/C cg14416269 chr4:6271139 WFS1 0.39 6.42 0.33 4.87e-10 Type 2 diabetes and other traits;Type 2 diabetes; CRC cis rs4662945 0.603 rs10168574 chr2:130267823 C/T cg05903289 chr2:130345205 NA -0.41 -8.06 -0.41 1.47e-14 Response to cytidine analogues (gemcitabine); CRC cis rs7312933 0.558 rs7305397 chr12:42850058 T/C cg19980929 chr12:42632907 YAF2 0.4 5.78 0.3 1.77e-8 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CRC cis rs2073499 1.000 rs6776145 chr3:50316119 C/T cg08207895 chr3:50388901 TUSC4;CYB561D2 -0.58 -6.48 -0.34 3.43e-10 Schizophrenia; CRC cis rs924607 0.898 rs905193 chr5:635095 T/C cg04476341 chr5:669733 TPPP 0.42 6.88 0.35 3.1e-11 Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia; CRC cis rs2257205 0.667 rs16943147 chr17:56720752 C/A cg25885038 chr17:56607967 SEPT4 -0.54 -5.85 -0.31 1.18e-8 Pancreatic cancer; CRC cis rs5167 0.504 rs8100120 chr19:45466058 T/C cg13119609 chr19:45449297 APOC2 0.31 5.82 0.31 1.42e-8 Blood protein levels; CRC cis rs7224737 1.000 rs2285657 chr17:40272594 C/A cg02450064 chr17:40260053 DHX58 -0.43 -6.14 -0.32 2.42e-9 Fibrinogen levels; CRC cis rs7618915 0.571 rs1961958 chr3:52585990 A/G cg07507251 chr3:52567010 NT5DC2 0.46 6.74 0.35 7.22e-11 Bipolar disorder; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg11829371 chr17:981724 ABR 0.42 6.62 0.34 1.43e-10 Intelligence (multi-trait analysis); CRC cis rs853679 0.517 rs2281588 chr6:28072602 G/A cg12172441 chr6:28176163 NA 0.62 7.38 0.38 1.28e-12 Depression; CRC cis rs10504229 1.000 rs17805332 chr8:58169798 A/G cg01721255 chr8:58191610 C8orf71 0.46 5.82 0.31 1.38e-8 Developmental language disorder (linguistic errors); CRC cis rs6674970 1.000 rs7546304 chr1:151114484 C/G cg11822372 chr1:151115635 SEMA6C 0.55 7.88 0.4 4.89e-14 Childhood ear infection; CRC cis rs4713118 0.869 rs7773070 chr6:27728827 T/C cg02683197 chr6:28174875 NA 0.65 8.86 0.44 4.95e-17 Parkinson's disease; CRC cis rs1862618 0.853 rs832578 chr5:56164223 C/T cg12311346 chr5:56204834 C5orf35 -0.79 -10.09 -0.49 4.73e-21 Initial pursuit acceleration; CRC trans rs66759488 0.739 rs10851451 chr15:47608991 A/G cg12813394 chr14:69095057 NA -0.36 -6.14 -0.32 2.33e-9 Lung cancer; CRC cis rs10046574 0.831 rs77693675 chr7:135142402 T/C cg27474649 chr7:135195673 CNOT4 0.69 5.72 0.3 2.41e-8 Peripheral arterial disease (traffic-related air pollution interaction); CRC trans rs11250098 0.548 rs7843470 chr8:10784492 C/G cg06636001 chr8:8085503 FLJ10661 -0.55 -8.09 -0.41 1.13e-14 Morning vs. evening chronotype; CRC cis rs56104184 0.775 rs56317021 chr19:49395960 C/T cg21252483 chr19:49399788 TULP2 -0.4 -6.05 -0.32 3.84e-9 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; CRC trans rs2243480 1.000 rs2257790 chr7:65600450 C/T cg10756647 chr7:56101905 PSPH 0.74 7.72 0.39 1.43e-13 Diabetic kidney disease; CRC cis rs780096 0.526 rs780106 chr2:27681598 A/C cg02592271 chr2:27665507 KRTCAP3 -0.28 -6.58 -0.34 1.83e-10 Total body bone mineral density; CRC cis rs6534441 0.697 rs60743503 chr4:125443757 C/T cg21609808 chr4:125404261 NA 0.39 5.63 0.3 3.77e-8 Major depressive disorder; CRC cis rs1692580 0.870 rs262680 chr1:2167149 C/T cg21194808 chr1:2205498 SKI 0.41 6.35 0.33 6.96e-10 Coronary artery disease; CRC cis rs2898681 0.519 rs3811781 chr4:53729166 T/G cg00791764 chr4:53727839 RASL11B 0.5 6.84 0.35 3.86e-11 Optic nerve measurement (cup area); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg26665246 chr5:179105570 CBY3 0.4 6.61 0.34 1.59e-10 Liver disease severity in Alagille syndrome; CRC cis rs2832191 0.791 rs2832199 chr21:30498501 G/A cg08807101 chr21:30365312 RNF160 -0.62 -9.76 -0.47 6.41e-20 Dental caries; CRC cis rs9393692 0.620 rs12525187 chr6:26337537 A/G cg13736514 chr6:26305472 NA -0.47 -7.64 -0.39 2.39e-13 Educational attainment; CRC cis rs7772486 0.754 rs2328709 chr6:146106819 A/G cg23711669 chr6:146136114 FBXO30 -0.77 -13.31 -0.59 1.24e-32 Lobe attachment (rater-scored or self-reported); CRC cis rs4566357 0.595 rs10206912 chr2:227921095 A/T cg11843606 chr2:227700838 RHBDD1 -0.45 -6.9 -0.36 2.71e-11 Coronary artery disease; CRC cis rs7264396 0.561 rs6058388 chr20:34571846 T/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.55 -8.72 -0.43 1.38e-16 Total cholesterol levels; CRC cis rs875971 0.862 rs6947339 chr7:65888470 T/C cg11764359 chr7:65958608 NA 0.57 8.45 0.42 9.59e-16 Aortic root size; CRC cis rs6815814 0.904 rs7664239 chr4:38786304 T/C cg06935464 chr4:38784597 TLR10 0.64 8.24 0.41 4.01e-15 Breast cancer; CRC cis rs6502050 0.799 rs9911129 chr17:80087819 C/T cg25804541 chr17:80189381 SLC16A3 -0.3 -5.84 -0.31 1.24e-8 Life satisfaction; CRC cis rs11585357 0.895 rs2977305 chr1:17613737 A/T cg08277548 chr1:17600880 PADI3 0.68 9.3 0.46 2.02e-18 Hair shape; CRC cis rs1046896 0.512 rs3785513 chr17:80886748 G/A cg19500275 chr17:80737654 TBCD 0.47 6.71 0.35 8.6e-11 Glycated hemoglobin levels; CRC cis rs3892630 0.878 rs2903759 chr19:33195947 A/G cg22980127 chr19:33182716 NUDT19 0.9 11.07 0.52 2.05e-24 Red blood cell traits; CRC cis rs1348850 0.874 rs714598 chr2:178455311 T/A cg02961200 chr2:178257176 LOC100130691;AGPS 0.47 6.77 0.35 5.89e-11 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs10256972 0.504 rs2949178 chr7:1209925 T/C cg22907277 chr7:1156413 C7orf50 0.66 10.3 0.49 9.26e-22 Longevity;Endometriosis; CRC trans rs11825064 0.606 rs11821186 chr11:134487480 T/C cg00033773 chr19:12779366 MORG1;C19orf56 0.43 5.97 0.31 6.19e-9 Seasonality; CRC cis rs4746818 0.892 rs10823298 chr10:70867083 T/C cg11621586 chr10:70884670 VPS26A 0.6 6.16 0.32 2.07e-9 Left atrial antero-posterior diameter; CRC cis rs929354 0.772 rs1182365 chr7:157017255 A/T cg16102536 chr7:156981717 UBE3C -0.4 -6.79 -0.35 5.41e-11 Body mass index; CRC trans rs4650994 1.000 rs4650999 chr1:178532188 A/C cg05059571 chr16:84539110 KIAA1609 0.43 6.62 0.34 1.45e-10 HDL cholesterol levels;HDL cholesterol; CRC cis rs514406 0.667 rs10788942 chr1:53210521 A/T cg08859206 chr1:53392774 SCP2 0.4 6.32 0.33 8.37e-10 Monocyte count; CRC cis rs356992 0.915 rs76674 chr2:60749109 C/T cg08426369 chr2:60753602 BCL11A -0.54 -7.77 -0.39 9.8e-14 Educational attainment (years of education); CRC cis rs7605827 0.866 rs11689153 chr2:15533899 A/G cg19274914 chr2:15703543 NA 0.39 5.87 0.31 1.06e-8 Educational attainment (years of education); CRC cis rs7258465 1.000 rs34010330 chr19:18559657 G/C cg06462663 chr19:18546047 ISYNA1 0.44 6.42 0.33 4.66e-10 Breast cancer; CRC trans rs10982213 0.830 rs2274163 chr9:117188714 C/T cg18565132 chr8:103613344 NA 0.38 6.25 0.33 1.28e-9 Interleukin-6 levels; CRC cis rs1865760 0.516 rs9295684 chr6:26069669 T/C cg17691542 chr6:26056736 HIST1H1C 0.55 8.44 0.42 1.06e-15 Height; CRC cis rs2836974 0.899 rs2836938 chr21:40574191 C/T cg11644478 chr21:40555479 PSMG1 0.81 12.33 0.56 5.83e-29 Cognitive function; CRC cis rs2455601 0.786 rs2568070 chr11:8976893 G/C cg21881798 chr11:8931708 C11orf17;ST5 -0.48 -5.7 -0.3 2.62e-8 Schizophrenia; CRC cis rs7647973 0.580 rs11130184 chr3:49229930 C/T cg20833759 chr3:49053208 WDR6;DALRD3 0.39 6.53 0.34 2.5e-10 Menarche (age at onset); CRC cis rs72634501 0.622 rs4660416 chr1:39578986 A/G cg18385671 chr1:39797026 MACF1 -0.43 -6.01 -0.31 5e-9 HDL cholesterol; CRC cis rs11785400 0.793 rs4736366 chr8:143742413 C/T cg10596483 chr8:143751796 JRK 0.45 5.98 0.31 5.68e-9 Schizophrenia; CRC cis rs1799949 1.000 rs8077486 chr17:41212805 C/T cg25072359 chr17:41440525 NA 0.52 8.23 0.41 4.32e-15 Menopause (age at onset); CRC cis rs9393692 0.620 rs9358927 chr6:26330492 T/G cg00631329 chr6:26305371 NA -0.55 -9.42 -0.46 7.95e-19 Educational attainment; CRC cis rs9322193 0.962 rs3805752 chr6:150116626 C/T cg00933542 chr6:150070202 PCMT1 0.31 6.01 0.31 4.88e-9 Lung cancer; CRC cis rs1008375 1.000 rs12507142 chr4:17656103 A/G cg02297831 chr4:17616191 MED28 0.49 6.66 0.34 1.14e-10 Parasitemia in Tripanosoma cruzi seropositivity; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg11179286 chr13:115047994 UPF3A 0.4 5.98 0.31 5.66e-9 Intelligence (multi-trait analysis); CRC trans rs475616 0.917 rs866919 chr10:30513283 C/T cg14315341 chr12:97346526 NEDD1 0.41 6.06 0.32 3.65e-9 Monocyte count; CRC cis rs6570726 0.577 rs9497315 chr6:145791967 C/T cg13319975 chr6:146136371 FBXO30 0.61 8.79 0.44 8.32e-17 Lobe attachment (rater-scored or self-reported); CRC cis rs6831352 0.918 rs29001224 chr4:100047373 G/A cg12011299 chr4:100065546 ADH4 -0.49 -9.27 -0.45 2.61e-18 Alcohol dependence; CRC cis rs4437462 0.898 rs4711244 chr6:11309828 A/T cg25250968 chr6:11318770 NEDD9 -0.4 -5.72 -0.3 2.45e-8 HIV-1 susceptibility; CRC cis rs9549260 0.755 rs9549244 chr13:41218685 C/T cg21288729 chr13:41239152 FOXO1 0.48 7.59 0.39 3.37e-13 Red blood cell count; CRC cis rs7826238 0.566 rs2945886 chr8:8148270 C/G cg08975724 chr8:8085496 FLJ10661 0.5 7.81 0.4 7.52e-14 Systolic blood pressure; CRC cis rs12550646 0.652 rs13438989 chr8:41685845 T/G cg12180191 chr8:41686706 ANK1 -0.45 -6.51 -0.34 2.81e-10 Reticulocyte fraction of red cells;Reticulocyte count; CRC cis rs853679 0.517 rs1947863 chr6:28099344 G/A cg06470822 chr6:28175283 NA 1.0 13.33 0.59 1.06e-32 Depression; CRC cis rs1153858 1.000 rs1049503 chr15:45653707 T/C cg21132104 chr15:45694354 SPATA5L1 0.6 8.92 0.44 3.33e-17 Homoarginine levels; CRC cis rs10540 1.000 rs61876341 chr11:495892 C/G cg03576123 chr11:487126 PTDSS2 -1.04 -10.79 -0.51 1.91e-23 Body mass index; CRC cis rs7666738 0.830 rs7673880 chr4:99057262 A/G cg17366294 chr4:99064904 C4orf37 0.44 7.44 0.38 8.6e-13 Colonoscopy-negative controls vs population controls; CRC cis rs12580194 0.593 rs61957936 chr12:55745719 A/G cg23425280 chr12:56401806 NA 0.44 5.61 0.3 4.19e-8 Cancer; CRC trans rs7395662 1.000 rs6485911 chr11:48654784 A/C cg21153622 chr11:89784906 NA -0.43 -6.97 -0.36 1.72e-11 HDL cholesterol; CRC cis rs2559856 1.000 rs2695285 chr12:102089043 G/A cg12924262 chr12:102091054 CHPT1 0.54 8.09 0.41 1.18e-14 Blood protein levels; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg11982332 chr8:96037194 C8orf38 0.5 6.86 0.35 3.44e-11 Anxiety disorder; CRC cis rs1572438 0.931 rs13215634 chr6:866545 C/T cg13447295 chr6:887704 NA 0.44 6.4 0.33 5.42e-10 Aging; CRC cis rs9486715 0.867 rs6568428 chr6:96903604 A/G cg18709589 chr6:96969512 KIAA0776 0.49 7.3 0.37 2.14e-12 Headache; CRC cis rs9322193 0.884 rs10872647 chr6:150079823 T/C cg13206674 chr6:150067644 NUP43 0.66 9.38 0.46 1.12e-18 Lung cancer; CRC cis rs1552244 0.554 rs59465469 chr3:9990800 G/C cg02579736 chr3:10068473 FANCD2;CIDECP 0.62 9.03 0.45 1.53e-17 Alzheimer's disease; CRC cis rs7474896 0.583 rs11011346 chr10:38009483 C/T cg25427524 chr10:38739819 LOC399744 -0.54 -6.48 -0.34 3.45e-10 Obesity (extreme); CRC cis rs1005277 0.579 rs1621040 chr10:38497232 T/C cg03665457 chr10:38645376 HSD17B7P2 -0.42 -5.96 -0.31 6.43e-9 Extrinsic epigenetic age acceleration; CRC cis rs490234 0.676 rs4838264 chr9:128225561 T/C cg14078157 chr9:128172775 NA -0.36 -6.0 -0.31 5.24e-9 Mean arterial pressure; CRC cis rs6540559 1.000 rs6659367 chr1:209982408 G/T cg25204440 chr1:209979598 IRF6 0.5 7.08 0.36 8.78e-12 Cleft lip with or without cleft palate; CRC cis rs9611565 0.659 rs116959331 chr22:41932774 A/G cg17554472 chr22:41940697 POLR3H -0.55 -5.93 -0.31 7.73e-9 Vitiligo; CRC cis rs6460942 1.000 rs6970095 chr7:12403840 G/A cg20607287 chr7:12443886 VWDE -0.66 -6.9 -0.36 2.61e-11 Coronary artery disease; CRC cis rs1124376 0.882 rs7618597 chr3:20134588 C/A cg05072819 chr3:20081367 KAT2B 0.49 5.9 0.31 8.95e-9 Bipolar disorder and schizophrenia; CRC cis rs853679 0.517 rs9348797 chr6:28137533 G/C cg02683197 chr6:28174875 NA 0.87 10.73 0.51 3.25e-23 Depression; CRC cis rs6502050 0.871 rs6416857 chr17:80063004 A/G cg02741985 chr17:80059408 CCDC57 -0.42 -6.77 -0.35 5.9e-11 Life satisfaction; CRC cis rs3806843 0.868 rs2531342 chr5:140130612 C/T cg19875535 chr5:140030758 IK -0.52 -8.16 -0.41 6.97e-15 Depressive symptoms (multi-trait analysis); CRC cis rs10193935 0.901 rs2374429 chr2:42677888 A/G cg27598129 chr2:42591480 NA -0.65 -7.62 -0.39 2.71e-13 Colonoscopy-negative controls vs population controls; CRC cis rs17376456 0.825 rs10038831 chr5:93124115 C/T cg25358565 chr5:93447407 FAM172A 1.0 9.49 0.46 4.89e-19 Diabetic retinopathy; CRC cis rs1707322 0.717 rs2253862 chr1:46081960 C/T cg06784218 chr1:46089804 CCDC17 -0.66 -12.05 -0.55 5.86e-28 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC trans rs3942852 0.868 rs6485808 chr11:48109151 A/G cg15704280 chr7:45808275 SEPT13 -0.61 -6.85 -0.35 3.55e-11 Acute lymphoblastic leukemia (childhood); CRC cis rs11971779 0.617 rs66652773 chr7:139109573 C/T cg07862535 chr7:139043722 LUC7L2 0.57 7.32 0.37 1.92e-12 Diisocyanate-induced asthma; CRC cis rs16975963 0.843 rs241955 chr19:38278677 A/G cg15135657 chr19:38346511 NA -0.42 -5.68 -0.3 3.03e-8 Longevity; CRC cis rs9325144 0.600 rs11183505 chr12:38759110 G/T cg26384229 chr12:38710491 ALG10B -0.53 -7.63 -0.39 2.54e-13 Morning vs. evening chronotype; CRC cis rs738322 1.000 rs4382 chr22:38570842 T/C cg17652424 chr22:38574118 PLA2G6 -0.22 -6.73 -0.35 7.71e-11 Cutaneous nevi; CRC cis rs896623 0.555 rs6837596 chr4:122131425 A/G cg19463078 chr4:122099598 TNIP3 0.41 6.31 0.33 8.76e-10 Lobe attachment (rater-scored or self-reported); CRC cis rs2342371 0.715 rs9846106 chr3:196126539 G/A cg15048948 chr3:196158458 UBXN7 0.51 6.26 0.33 1.18e-9 Fat distribution (HIV); CRC cis rs7552404 0.924 rs7546641 chr1:76158035 T/C cg22875332 chr1:76189707 ACADM 0.76 11.1 0.52 1.61e-24 Blood metabolite levels;Acylcarnitine levels; CRC cis rs490234 0.702 rs1339499 chr9:128406453 T/C cg14078157 chr9:128172775 NA -0.39 -6.53 -0.34 2.45e-10 Mean arterial pressure; CRC cis rs11645898 0.688 rs398580 chr16:72095453 A/G cg14768367 chr16:72042858 DHODH -0.71 -7.24 -0.37 3.25e-12 Blood protein levels; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg11528995 chr1:117210575 IGSF3 0.39 6.44 0.33 4.26e-10 Liver disease severity in Alagille syndrome; CRC cis rs7666738 0.830 rs1593573 chr4:98925293 T/C cg17366294 chr4:99064904 C4orf37 0.43 7.32 0.37 1.95e-12 Colonoscopy-negative controls vs population controls; CRC cis rs3741404 0.560 rs2875748 chr11:63915537 G/A cg06243084 chr11:63990629 FERMT3 0.46 7.28 0.37 2.41e-12 Platelet count; CRC cis rs12594515 1.000 rs8032835 chr15:45997897 C/G cg19682013 chr15:45996608 NA 0.32 6.62 0.34 1.46e-10 Waist circumference;Weight; CRC cis rs3820068 0.581 rs72645864 chr1:15921153 C/T cg24675056 chr1:15929824 NA 0.47 6.29 0.33 1.01e-9 Systolic blood pressure; CRC cis rs12594515 1.000 rs58368732 chr15:45990531 G/C cg06207120 chr15:45996521 NA 0.32 7.75 0.39 1.14e-13 Waist circumference;Weight; CRC cis rs2032447 0.507 rs199741 chr6:25931577 A/G cg15691649 chr6:25882328 NA -0.6 -7.61 -0.39 2.97e-13 Intelligence (multi-trait analysis); CRC cis rs9925964 0.967 rs889548 chr16:31137712 A/G cg03418659 chr16:31128414 MYST1 -0.53 -7.73 -0.39 1.31e-13 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC trans rs1324183 0.915 rs2224860 chr9:13550069 C/A cg07050692 chr8:61664695 CHD7 -0.44 -5.98 -0.31 5.97e-9 Corneal structure; CRC trans rs6708331 0.517 rs11692018 chr2:70369154 A/C cg06926377 chr15:40443853 NA 0.41 6.08 0.32 3.4e-9 Obesity-related traits; CRC cis rs2120019 0.938 rs1867150 chr15:75321139 T/C cg11632617 chr15:75315747 PPCDC -0.57 -7.79 -0.39 8.82e-14 Blood trace element (Zn levels); CRC trans rs12517041 1.000 rs6891825 chr5:23299740 C/A ch.8.1293020R chr8:59333349 UBXN2B -0.55 -6.17 -0.32 2.05e-9 Calcium levels; CRC cis rs898097 1.000 rs898098 chr17:80904564 G/A cg17346650 chr17:80929145 B3GNTL1 0.34 5.66 0.3 3.23e-8 Breast cancer; CRC cis rs6585424 1.000 rs2228427 chr10:81926718 A/G cg11900509 chr10:81946545 ANXA11 -0.76 -9.32 -0.46 1.78e-18 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs6866344 0.697 rs17184344 chr5:178129281 A/G cg10224037 chr5:178157518 ZNF354A 0.79 11.48 0.53 6.95e-26 Neutrophil percentage of white cells; CRC cis rs939584 0.935 rs7569102 chr2:631335 G/T cg03610516 chr2:642275 NA 0.43 5.61 0.3 4.36e-8 Body mass index; CRC cis rs72772090 0.634 rs17401901 chr5:96091925 C/T cg17330273 chr5:96107758 CAST;ERAP1 -0.68 -6.55 -0.34 2.22e-10 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs2050392 0.624 rs303444 chr10:30729347 C/T cg25182066 chr10:30743637 MAP3K8 -0.45 -6.02 -0.31 4.69e-9 Inflammatory bowel disease; CRC cis rs2303745 0.589 rs1864116 chr19:17393015 C/T cg15110403 chr19:17392923 ANKLE1 -0.36 -6.0 -0.31 5.23e-9 Systemic lupus erythematosus; CRC cis rs35264875 1.000 rs72928636 chr11:68848386 C/T cg15234197 chr11:68924956 NA 0.44 6.12 0.32 2.72e-9 Blond vs. brown hair color; CRC cis rs3824867 0.920 rs80241400 chr11:47453828 T/C cg05585544 chr11:47624801 NA 0.41 6.31 0.33 8.88e-10 Mean corpuscular hemoglobin; CRC trans rs7613875 0.620 rs11721204 chr3:49982765 C/T cg21665057 chr3:196295764 WDR53;FBXO45 0.46 6.58 0.34 1.84e-10 Body mass index; CRC cis rs7552404 0.556 rs12124417 chr1:76353294 T/C cg10523679 chr1:76189770 ACADM 0.46 6.01 0.31 5.02e-9 Blood metabolite levels;Acylcarnitine levels; CRC cis rs10504229 0.595 rs77615399 chr8:58117394 C/G cg22535103 chr8:58192502 C8orf71 -0.7 -9.34 -0.46 1.47e-18 Developmental language disorder (linguistic errors); CRC cis rs9911578 0.867 rs72628394 chr17:57121313 C/T cg05425664 chr17:57184151 TRIM37 0.47 7.45 0.38 8.08e-13 Intelligence (multi-trait analysis); CRC cis rs796364 0.789 rs1653297 chr2:201075483 C/T cg23649088 chr2:200775458 C2orf69 0.48 5.8 0.3 1.59e-8 Schizophrenia; CRC cis rs875971 0.862 rs10274883 chr7:66116091 C/T cg11764359 chr7:65958608 NA -0.59 -8.69 -0.43 1.7e-16 Aortic root size; CRC cis rs9487051 0.802 rs6568558 chr6:109592701 A/T cg01475377 chr6:109611718 NA -0.47 -8.73 -0.43 1.28e-16 Reticulocyte fraction of red cells; CRC cis rs6060717 0.536 rs3787173 chr20:34472105 C/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.53 -6.16 -0.32 2.14e-9 Hip circumference adjusted for BMI; CRC cis rs8062405 1.000 rs1987472 chr16:28825777 C/T cg16576597 chr16:28551801 NUPR1 0.49 7.13 0.37 6.53e-12 Cognitive ability (multi-trait analysis);Cognitive ability; CRC cis rs3760982 1.000 rs4803658 chr19:44290013 T/A cg21496419 chr19:44306685 LYPD5 0.35 6.54 0.34 2.31e-10 Breast cancer (estrogen-receptor negative);Breast cancer; CRC cis rs4731207 0.698 rs10085888 chr7:124486391 T/C cg23710748 chr7:124431027 NA 0.38 6.08 0.32 3.42e-9 Cutaneous malignant melanoma; CRC cis rs10751667 0.666 rs10902235 chr11:938892 T/C cg06064525 chr11:970664 AP2A2 -0.31 -6.16 -0.32 2.18e-9 Alzheimer's disease (late onset); CRC cis rs4713118 0.869 rs9393851 chr6:27699581 A/T cg15845792 chr6:28175446 NA 0.65 9.11 0.45 7.98e-18 Parkinson's disease; CRC cis rs10504229 0.683 rs56211106 chr8:58113497 A/G cg02725872 chr8:58115012 NA -0.65 -11.61 -0.54 2.34e-26 Developmental language disorder (linguistic errors); CRC cis rs7937682 0.737 rs542275 chr11:111431614 C/T cg19812747 chr11:111475976 SIK2 -0.45 -7.39 -0.38 1.22e-12 Primary sclerosing cholangitis; CRC cis rs9814567 0.929 rs9815297 chr3:134215052 A/G cg06109529 chr3:134205091 CEP63;ANAPC13 -0.8 -11.9 -0.55 2.11e-27 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs6694672 1.000 rs1332663 chr1:197109042 C/T cg13682187 chr1:196946512 CFHR5 0.46 7.37 0.38 1.38e-12 Asthma; CRC cis rs9640161 0.871 rs56156367 chr7:150047201 A/T cg13722127 chr7:150037890 RARRES2 0.41 6.24 0.33 1.32e-9 Blood protein levels;Circulating chemerin levels; CRC cis rs4423214 0.921 rs11603330 chr11:71153459 C/A cg05163923 chr11:71159392 DHCR7 0.63 9.32 0.46 1.68e-18 Vitamin D levels; CRC cis rs2976388 0.609 rs2717550 chr8:143787808 T/A cg22687807 chr8:143858763 LYNX1 0.51 9.13 0.45 7.1e-18 Urinary tract infection frequency; CRC trans rs9388451 0.874 rs13209968 chr6:126089285 G/C cg05039488 chr6:79577232 IRAK1BP1 -0.55 -8.39 -0.42 1.41e-15 Brugada syndrome; CRC cis rs9399135 0.967 rs7741626 chr6:135314182 C/T cg24558204 chr6:135376177 HBS1L 0.51 8.11 0.41 1.01e-14 Red blood cell count; CRC cis rs12971120 0.947 rs8084109 chr18:72168312 T/A cg26446133 chr18:72167187 CNDP2 -0.76 -15.14 -0.64 1.14e-39 Refractive error; CRC cis rs2120019 0.935 rs12591119 chr15:75355944 A/G cg17294928 chr15:75287854 SCAMP5 -0.8 -11.54 -0.54 4.13e-26 Blood trace element (Zn levels); CRC cis rs561341 1.000 rs2344312 chr17:30243583 G/T cg19193384 chr17:30244184 NA -0.5 -6.85 -0.35 3.58e-11 Hip circumference adjusted for BMI; CRC cis rs6951245 0.872 rs74360401 chr7:1067403 G/A cg26224354 chr7:1096374 C7orf50;GPR146 -0.88 -11.08 -0.52 1.89e-24 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs6496667 0.542 rs58182460 chr15:90897309 A/T cg04176472 chr15:90893244 GABARAPL3 0.51 7.73 0.39 1.33e-13 Rheumatoid arthritis; CRC cis rs9549367 0.713 rs3024746 chr13:113821777 G/A cg00898013 chr13:113819073 PROZ -0.56 -8.12 -0.41 9.6e-15 Platelet distribution width; CRC trans rs2727020 0.612 rs603672 chr11:49234566 T/A cg03929089 chr4:120376271 NA 0.8 13.23 0.59 2.48e-32 Coronary artery disease; CRC trans rs800082 1.000 rs9849975 chr3:144294530 A/G cg24215973 chr2:240111563 HDAC4 -0.51 -7.1 -0.36 7.92e-12 Smoking behavior; CRC cis rs9916302 0.851 rs11870631 chr17:37645129 C/T cg07936489 chr17:37558343 FBXL20 -0.84 -13.1 -0.59 7.38e-32 Glomerular filtration rate (creatinine); CRC cis rs17376456 1.000 rs17376456 chr5:93557702 C/T cg25358565 chr5:93447407 FAM172A -1.09 -10.14 -0.49 3.36e-21 Diabetic retinopathy; CRC cis rs6840360 0.904 rs6813516 chr4:152594407 C/G cg09659197 chr4:152720779 NA 0.52 11.05 0.52 2.32e-24 Intelligence (multi-trait analysis); CRC cis rs3771570 0.901 rs28433352 chr2:242339656 A/G cg21155796 chr2:242212141 HDLBP 0.56 6.74 0.35 6.93e-11 Prostate cancer; CRC cis rs1832871 0.711 rs9457264 chr6:158689367 G/A cg07165851 chr6:158734300 TULP4 0.6 7.58 0.39 3.46e-13 Height; CRC cis rs2898681 0.581 rs10003908 chr4:53681089 T/C cg00338735 chr4:53728038 RASL11B 0.39 5.92 0.31 8.08e-9 Optic nerve measurement (cup area); CRC cis rs4332037 0.722 rs28705934 chr7:1916116 T/A cg23422044 chr7:1970798 MAD1L1 -0.59 -7.82 -0.4 7.47e-14 Bipolar disorder; CRC cis rs7726839 0.561 rs4957048 chr5:583442 G/A cg16447950 chr5:562315 NA -0.85 -12.52 -0.57 1.1e-29 Obesity-related traits; CRC trans rs35110281 0.720 rs162372 chr21:44928863 C/T cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO -0.5 -8.16 -0.41 7.26e-15 Mean corpuscular volume; CRC cis rs6089584 0.888 rs6061966 chr20:60607936 C/G cg18761221 chr20:60518478 NA 0.46 7.39 0.38 1.23e-12 Body mass index; CRC cis rs7617773 1.000 rs11711766 chr3:48193170 G/C cg11946769 chr3:48343235 NME6 -0.51 -6.85 -0.35 3.74e-11 Coronary artery disease; CRC cis rs524023 0.914 rs2360872 chr11:64353405 T/C cg14139581 chr11:64358342 SLC22A12 -0.38 -6.09 -0.32 3.14e-9 Urate levels in obese individuals; CRC cis rs7937682 0.575 rs7127010 chr11:111770782 C/T cg19812747 chr11:111475976 SIK2 0.43 6.4 0.33 5.4e-10 Primary sclerosing cholangitis; CRC cis rs1568889 0.838 rs11030220 chr11:28145769 C/G cg06544937 chr11:28130018 METT5D1;KIF18A 0.91 15.54 0.65 3.21e-41 Bipolar disorder; CRC cis rs4604732 0.631 rs12031721 chr1:247623773 G/A cg12758973 chr1:247694275 LOC148824;OR2C3 0.44 6.23 0.32 1.46e-9 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg14517217 chr17:75447478 SEPT9 0.4 6.35 0.33 7.2e-10 Liver disease severity in Alagille syndrome; CRC cis rs8177253 0.896 rs34252038 chr3:133490621 G/T cg01448562 chr3:133502909 NA -0.54 -9.08 -0.45 1.03e-17 Iron status biomarkers; CRC cis rs2857891 0.817 rs2239732 chr11:6976689 C/G cg04053776 chr11:6947353 ZNF215 0.41 5.88 0.31 1.01e-8 Response to cytadine analogues (cytosine arabinoside); CRC cis rs1048238 0.818 rs945421 chr1:16345393 T/C cg24140574 chr1:16342155 HSPB7 0.43 6.24 0.33 1.35e-9 Systolic blood pressure; CRC cis rs9443645 0.901 rs9343844 chr6:79586463 T/A cg05283184 chr6:79620031 NA -0.58 -9.34 -0.46 1.48e-18 Intelligence (multi-trait analysis); CRC cis rs1843834 0.539 rs10177898 chr2:225437552 C/T cg22455342 chr2:225449267 CUL3 0.67 9.05 0.45 1.29e-17 IgE levels in asthmatics (D.p. specific); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg05165064 chr20:18037039 OVOL2 0.4 6.05 0.32 3.97e-9 Response to antipsychotic treatment; CRC trans rs1814175 0.727 rs2140597 chr11:49873946 G/A cg21153622 chr11:89784906 NA -0.38 -6.09 -0.32 3.21e-9 Height; CRC cis rs6502050 0.769 rs8068708 chr17:80120424 T/C cg25804541 chr17:80189381 SLC16A3 -0.3 -5.83 -0.31 1.3e-8 Life satisfaction; CRC cis rs8180040 0.620 rs11917361 chr3:47070497 G/T cg27129171 chr3:47204927 SETD2 -0.74 -11.63 -0.54 2.07e-26 Colorectal cancer; CRC trans rs61931739 0.500 rs6488224 chr12:34537205 T/C cg26384229 chr12:38710491 ALG10B 0.59 8.77 0.44 9.64e-17 Morning vs. evening chronotype; CRC cis rs870825 0.616 rs7692367 chr4:185651056 T/C cg04058563 chr4:185651563 MLF1IP 0.72 9.28 0.46 2.4e-18 Blood protein levels; CRC cis rs34172651 0.517 rs36113933 chr16:24838862 A/G cg00339695 chr16:24857497 SLC5A11 0.42 8.55 0.43 4.59e-16 Intelligence (multi-trait analysis); CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg05749548 chr13:48611855 NUDT15 0.45 6.34 0.33 7.46e-10 Anxiety disorder; CRC cis rs3849570 0.961 rs11710970 chr3:81693489 T/C cg07356753 chr3:81810745 GBE1 -0.7 -9.79 -0.47 4.95e-20 Waist circumference;Body mass index; CRC cis rs713477 1.000 rs12888234 chr14:55911352 T/A cg13175173 chr14:55914753 NA -0.52 -9.85 -0.48 3.19e-20 Pediatric bone mineral content (femoral neck); CRC cis rs769267 1.000 rs8103197 chr19:19443466 C/T cg02546618 chr19:19431379 KIAA0892;SF4 -0.46 -6.46 -0.34 3.85e-10 Tonsillectomy; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg17886162 chr1:183440258 SMG7 0.42 6.1 0.32 3.02e-9 Intelligence (multi-trait analysis); CRC cis rs7666738 0.962 rs2865986 chr4:99067907 A/G cg17366294 chr4:99064904 C4orf37 0.46 7.3 0.37 2.22e-12 Colonoscopy-negative controls vs population controls; CRC cis rs1862618 0.802 rs2591949 chr5:56132627 T/C cg18230493 chr5:56204884 C5orf35 -0.71 -9.19 -0.45 4.44e-18 Initial pursuit acceleration; CRC cis rs8031584 0.958 rs3512 chr15:31235005 G/C cg14829155 chr15:31115871 NA -0.51 -8.24 -0.41 4.19e-15 Huntington's disease progression; CRC cis rs12541635 0.677 rs2880950 chr8:106983624 C/A cg10147462 chr8:107024639 NA 0.57 9.92 0.48 1.85e-20 Age of smoking initiation; CRC cis rs10493773 0.775 rs12756013 chr1:86153532 C/T cg17807903 chr1:86174739 ZNHIT6 -0.52 -11.7 -0.54 1.14e-26 Urate levels in overweight individuals; CRC cis rs2019137 0.560 rs4849179 chr2:113985170 C/T cg11763394 chr2:113992921 PAX8;LOC440839;LOC654433 0.64 9.98 0.48 1.2e-20 Lymphocyte counts; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg11555878 chr7:7607056 MIOS 0.38 6.13 0.32 2.46e-9 Intelligence (multi-trait analysis); CRC cis rs2415984 0.579 rs8010773 chr14:46956863 T/C cg14871534 chr14:47121158 RPL10L -0.4 -5.83 -0.31 1.32e-8 Number of children ever born; CRC cis rs939574 1.000 rs7574937 chr2:220099331 C/T cg00496455 chr2:220118770 TUBA4A;TUBA4B 0.92 9.34 0.46 1.45e-18 Platelet distribution width; CRC cis rs57221529 0.713 rs72703072 chr5:590626 A/G cg17948913 chr5:572064 NA 0.52 5.95 0.31 6.79e-9 Lung disease severity in cystic fibrosis; CRC cis rs2836974 0.897 rs13049280 chr21:40594656 C/G cg06238570 chr21:40685208 BRWD1 0.76 10.27 0.49 1.23e-21 Cognitive function; CRC cis rs10883723 0.810 rs10786669 chr10:104256094 C/G cg04362960 chr10:104952993 NT5C2 -0.43 -6.1 -0.32 2.9e-9 Allergic disease (asthma, hay fever or eczema); CRC cis rs62432291 0.681 rs419836 chr6:159659481 C/T cg14500486 chr6:159655392 FNDC1 -0.77 -10.43 -0.5 3.48e-22 Joint mobility (Beighton score); CRC cis rs7216064 1.000 rs62084251 chr17:65878736 G/A cg12091567 chr17:66097778 LOC651250 -0.67 -7.74 -0.39 1.24e-13 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CRC cis rs2243480 1.000 rs6964530 chr7:65718851 G/C cg25985355 chr7:65971099 NA 0.51 5.73 0.3 2.31e-8 Diabetic kidney disease; CRC cis rs728616 0.764 rs61859016 chr10:81852500 C/A cg11900509 chr10:81946545 ANXA11 -0.56 -5.83 -0.31 1.3e-8 Chronic obstructive pulmonary disease-related biomarkers; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg25234159 chr3:184870893 C3orf70 0.41 6.04 0.32 4.08e-9 Response to antipsychotic treatment; CRC cis rs7949030 0.626 rs11231145 chr11:62328854 G/A cg11742103 chr11:62369870 EML3;MTA2 0.62 11.85 0.55 3.28e-27 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; CRC cis rs9814567 0.806 rs1880375 chr3:134322163 C/A cg06541857 chr3:134203789 ANAPC13;CEP63 -0.37 -5.73 -0.3 2.3e-8 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC trans rs1997103 1.000 rs2009441 chr7:55405989 A/G cg20935933 chr6:143382018 AIG1 0.5 6.58 0.34 1.89e-10 QRS interval (sulfonylurea treatment interaction); CRC cis rs919433 0.854 rs13013049 chr2:198208664 C/T cg20885578 chr2:198174922 NA -0.38 -5.65 -0.3 3.52e-8 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC cis rs7811142 0.830 rs7792959 chr7:99972403 C/T cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.88 11.8 0.55 5.03e-27 Platelet count; CRC cis rs9660992 0.710 rs7367930 chr1:205235512 A/G cg21643547 chr1:205240462 TMCC2 -0.45 -7.26 -0.37 2.84e-12 Mean corpuscular volume;Mean platelet volume; CRC cis rs7666738 0.830 rs9995386 chr4:98907826 T/C cg05340658 chr4:99064831 C4orf37 0.56 8.42 0.42 1.21e-15 Colonoscopy-negative controls vs population controls; CRC cis rs875971 0.862 rs7809814 chr7:65615397 G/A cg18252515 chr7:66147081 NA 0.39 5.61 0.3 4.37e-8 Aortic root size; CRC cis rs546131 0.928 rs516228 chr11:34838823 C/T cg06937548 chr11:34938143 PDHX;APIP 0.42 6.37 0.33 6.26e-10 Lung disease severity in cystic fibrosis; CRC cis rs10946940 0.965 rs4713112 chr6:27516833 G/T cg15845792 chr6:28175446 NA -0.46 -6.17 -0.32 2.06e-9 Systemic lupus erythematosus; CRC cis rs4713118 0.662 rs9468278 chr6:28028482 C/T cg23161317 chr6:28129485 ZNF389 0.44 5.76 0.3 1.96e-8 Parkinson's disease; CRC cis rs12594515 1.000 rs12594515 chr15:45985071 C/G cg19682013 chr15:45996608 NA -0.33 -6.83 -0.35 4.18e-11 Waist circumference;Weight; CRC cis rs7811142 1.000 rs73161759 chr7:100009994 T/C cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.74 10.28 0.49 1.11e-21 Platelet count; CRC cis rs9611565 0.659 rs12484175 chr22:41953739 A/C cg06481639 chr22:41940642 POLR3H -0.5 -5.83 -0.31 1.33e-8 Vitiligo; CRC cis rs11123170 0.640 rs931472 chr2:113969948 C/T cg21482265 chr2:113992762 PAX8;LOC440839;LOC654433 -0.53 -7.09 -0.36 8.32e-12 Renal function-related traits (BUN); CRC cis rs2346177 0.844 rs34712412 chr2:46652428 G/A cg26688816 chr2:46740690 ATP6V1E2 -0.46 -6.91 -0.36 2.5e-11 HDL cholesterol; CRC cis rs736408 0.509 rs2590838 chr3:52622086 G/A cg15147215 chr3:52552868 STAB1 -0.71 -13.4 -0.59 5.84e-33 Bipolar disorder; CRC trans rs617791 0.669 rs4994056 chr11:65750997 G/A cg17712092 chr4:129076599 LARP1B 0.67 11.04 0.52 2.51e-24 Breast cancer; CRC cis rs28655083 0.529 rs4544253 chr16:77104774 T/C cg01753188 chr16:77233325 SYCE1L;MON1B 0.46 6.59 0.34 1.76e-10 Lobe attachment (rater-scored or self-reported); CRC cis rs929354 0.629 rs6950739 chr7:156982450 T/C cg05182265 chr7:156933206 UBE3C -0.76 -14.25 -0.62 3.21e-36 Body mass index; CRC cis rs6500395 1.000 rs1224 chr16:48572817 G/A cg04672837 chr16:48644449 N4BP1 0.45 6.71 0.35 8.76e-11 Response to tocilizumab in rheumatoid arthritis; CRC cis rs950169 0.763 rs35372971 chr15:84941795 G/A cg17507749 chr15:85114479 UBE2QP1 0.74 10.62 0.51 7.37e-23 Schizophrenia; CRC cis rs10504229 0.683 rs73603874 chr8:58108340 G/A cg21724239 chr8:58056113 NA 0.52 6.97 0.36 1.79e-11 Developmental language disorder (linguistic errors); CRC cis rs977987 0.806 rs4888405 chr16:75428196 A/C cg03315344 chr16:75512273 CHST6 0.53 8.88 0.44 4.28e-17 Dupuytren's disease; CRC trans rs11039798 0.528 rs10839208 chr11:49030456 C/T cg03929089 chr4:120376271 NA 0.59 6.26 0.33 1.23e-9 Axial length; CRC cis rs1799949 1.000 rs4793191 chr17:41204377 A/G cg01879757 chr17:41196368 BRCA1 -0.41 -6.26 -0.33 1.24e-9 Menopause (age at onset); CRC cis rs9902453 0.791 rs9904051 chr17:28244122 T/C cg26525008 chr17:28256777 EFCAB5;SSH2 0.65 10.49 0.5 2.17e-22 Coffee consumption (cups per day); CRC cis rs7626444 0.625 rs843539 chr3:196474856 T/C cg12930392 chr3:196481615 PAK2 0.41 7.3 0.37 2.23e-12 Monocyte count; CRC cis rs2204008 0.805 rs3863360 chr12:37966432 C/T cg26384229 chr12:38710491 ALG10B 0.67 9.31 0.46 1.91e-18 Bladder cancer; CRC cis rs951366 0.903 rs823116 chr1:205720483 G/A cg24503407 chr1:205819492 PM20D1 0.51 7.63 0.39 2.5e-13 Menarche (age at onset); CRC cis rs459193 1.000 rs40271 chr5:55796319 A/G cg00049729 chr5:55776345 NA -0.38 -5.66 -0.3 3.3e-8 Coronary artery disease;Type 2 diabetes;Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);Waist-to-hip ratio adjusted for BMI in non-smokers;Waist-to-hip ratio adjusted for BMI (smoking interaction);Waist-to-hip ratio adjusted for body mass index;Waist-hip ratio;Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction); CRC cis rs2839186 0.619 rs2187118 chr21:47611310 C/T cg09417038 chr21:47716443 C21orf57 -0.36 -6.11 -0.32 2.89e-9 Testicular germ cell tumor; CRC cis rs1728785 1.000 rs1170443 chr16:68573295 G/C cg02972257 chr16:68554789 NA -0.57 -6.92 -0.36 2.41e-11 Ulcerative colitis; CRC cis rs16924133 0.557 rs66548785 chr11:33121605 T/C cg05567920 chr11:33183001 CSTF3 -0.78 -5.92 -0.31 7.95e-9 Anger; CRC cis rs12484776 0.735 rs6001799 chr22:40539200 G/A cg21771250 chr22:40406049 FAM83F 0.32 5.82 0.31 1.43e-8 Uterine fibroids; CRC cis rs13108904 0.935 rs4246685 chr4:1279727 T/C cg05665937 chr4:1216051 CTBP1 0.4 5.75 0.3 1.99e-8 Obesity-related traits; CRC cis rs8072100 0.688 rs8079142 chr17:45442049 G/A cg08085267 chr17:45401833 C17orf57 -0.59 -9.11 -0.45 7.96e-18 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC trans rs875971 0.660 rs2191268 chr7:66110224 C/T cg13789711 chr9:139743225 PHPT1 -0.42 -6.36 -0.33 6.67e-10 Aortic root size; CRC trans rs2727020 0.554 rs7111711 chr11:49557880 G/A cg11707556 chr5:10655725 ANKRD33B -0.49 -7.92 -0.4 3.65e-14 Coronary artery disease; CRC cis rs1448094 0.556 rs11611968 chr12:86168022 G/A cg18827107 chr12:86230957 RASSF9 -0.4 -6.18 -0.32 1.89e-9 Major depressive disorder; CRC cis rs10927875 0.541 rs1739844 chr1:16343322 T/C cg22431228 chr1:16359049 CLCNKA -0.38 -6.91 -0.36 2.52e-11 Dilated cardiomyopathy; CRC trans rs17685 0.753 rs2108274 chr7:75781636 C/A cg19862616 chr7:65841803 NCRNA00174 0.99 18.42 0.71 1.51e-52 Coffee consumption;Coffee consumption (cups per day); CRC cis rs9311474 0.508 rs7625743 chr3:52606366 C/G cg18099408 chr3:52552593 STAB1 -0.46 -7.97 -0.4 2.56e-14 Electroencephalogram traits; CRC cis rs6502050 0.835 rs7208673 chr17:80165908 G/C cg13198984 chr17:80129470 CCDC57 0.44 7.91 0.4 3.98e-14 Life satisfaction; CRC cis rs1451375 0.617 rs2060763 chr7:50542359 G/A cg18232548 chr7:50535776 DDC -0.43 -5.64 -0.3 3.76e-8 Malaria; CRC trans rs2727020 0.575 rs10769587 chr11:49549849 C/G cg15704280 chr7:45808275 SEPT13 -0.95 -17.56 -0.7 3.48e-49 Coronary artery disease; CRC cis rs7647973 0.600 rs11920267 chr3:49275964 G/A cg07636037 chr3:49044803 WDR6 0.84 12.66 0.57 3.49e-30 Menarche (age at onset); CRC cis rs4713118 0.868 rs7756968 chr6:27734954 C/G cg15786705 chr6:28176104 NA 0.59 6.59 0.34 1.79e-10 Parkinson's disease; CRC cis rs10870270 1.000 rs10870271 chr10:133754807 A/G cg08754478 chr10:133766260 PPP2R2D 0.65 9.49 0.46 4.77e-19 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; CRC trans rs1814175 0.533 rs4528310 chr11:49983106 C/A cg03929089 chr4:120376271 NA -0.91 -16.17 -0.67 1.06e-43 Height; CRC cis rs921968 0.509 rs3856548 chr2:219398164 C/T cg02176678 chr2:219576539 TTLL4 -0.58 -9.2 -0.45 4.09e-18 Mean corpuscular hemoglobin concentration; CRC cis rs1691799 0.867 rs1168347 chr12:66757303 T/C cg16791601 chr12:66731901 HELB -0.7 -11.72 -0.54 9.46e-27 White blood cell count (basophil); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg26438705 chr16:1661097 IFT140 0.37 6.13 0.32 2.48e-9 Liver disease severity in Alagille syndrome; CRC cis rs6558174 0.965 rs4872524 chr8:22489537 A/G cg03733263 chr8:22462867 KIAA1967 0.47 6.43 0.33 4.56e-10 Breast cancer; CRC cis rs7827545 0.545 rs57219802 chr8:135554231 C/T cg17885191 chr8:135476712 NA 0.75 7.98 0.4 2.42e-14 Hypertension (SNP x SNP interaction); CRC cis rs10832963 1.000 rs11024739 chr11:18645843 A/C cg09201001 chr11:18656081 SPTY2D1 -0.77 -12.15 -0.56 2.55e-28 Breast cancer; CRC cis rs7659604 0.728 rs3924987 chr4:122689784 G/T cg19748678 chr4:122722346 EXOSC9 0.68 10.68 0.51 4.52e-23 Type 2 diabetes; CRC cis rs2576037 0.545 rs9948405 chr18:44494527 C/G cg23996704 chr18:44553084 KATNAL2 -0.37 -7.52 -0.38 5.23e-13 Personality dimensions; CRC cis rs7131987 0.650 rs11050208 chr12:29510369 T/G cg09582351 chr12:29534625 ERGIC2 -0.35 -7.11 -0.36 7.4e-12 QT interval; CRC cis rs2228479 0.850 rs11642010 chr16:89845111 T/C cg19635926 chr16:89946313 TCF25 0.67 5.67 0.3 3.14e-8 Skin colour saturation; CRC cis rs1865760 0.566 rs4529296 chr6:26083135 C/G cg17691542 chr6:26056736 HIST1H1C 0.56 8.51 0.42 6.1e-16 Height; CRC trans rs2553218 0.690 rs8032415 chr15:54851945 A/G cg08751499 chr6:12290573 EDN1 0.53 6.96 0.36 1.84e-11 Immune response to smallpox vaccine (IL-6); CRC cis rs6952808 1.000 rs6978048 chr7:1886872 T/G cg00106254 chr7:1943704 MAD1L1 -0.44 -6.26 -0.33 1.22e-9 Bipolar disorder and schizophrenia; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg11972953 chr2:30370168 YPEL5 0.43 5.96 0.31 6.53e-9 Anxiety disorder; CRC cis rs3026101 0.671 rs3026109 chr17:5284480 C/T cg25236894 chr17:5323110 RPAIN;NUP88 -0.44 -7.15 -0.37 5.6e-12 Body mass index; CRC cis rs6500602 0.893 rs8061742 chr16:4489436 T/C cg08645402 chr16:4508243 NA 0.56 9.0 0.44 1.86e-17 Schizophrenia; CRC trans rs10802346 0.514 rs5024440 chr1:246372608 G/C cg13514129 chr1:39547527 MACF1 0.57 8.58 0.43 3.74e-16 Fractional exhaled nitric oxide (childhood); CRC cis rs10479542 0.683 rs7380706 chr5:178961872 C/T cg09060608 chr5:178986726 RUFY1 0.39 6.06 0.32 3.77e-9 Lung cancer; CRC cis rs514406 0.792 rs1242201 chr1:53344748 G/A cg25767906 chr1:53392781 SCP2 -0.52 -8.37 -0.42 1.63e-15 Monocyte count; CRC cis rs6460942 0.908 rs6956500 chr7:12232120 T/C cg06484146 chr7:12443880 VWDE -0.59 -6.0 -0.31 5.18e-9 Coronary artery disease; CRC cis rs7605827 0.930 rs6431709 chr2:15638296 T/C cg19274914 chr2:15703543 NA 0.39 6.0 0.31 5.1e-9 Educational attainment (years of education); CRC cis rs2153535 0.580 rs9505458 chr6:8479215 A/G cg21535247 chr6:8435926 SLC35B3 0.5 7.54 0.38 4.72e-13 Motion sickness; CRC trans rs2727020 0.553 rs61904166 chr11:49581461 T/C cg03929089 chr4:120376271 NA -0.92 -16.65 -0.68 1.44e-45 Coronary artery disease; CRC cis rs10924970 0.934 rs10802572 chr1:235426121 A/T cg26050004 chr1:235667680 B3GALNT2 0.39 5.76 0.3 1.93e-8 Asthma; CRC cis rs514406 0.861 rs505444 chr1:53251860 C/T cg25767906 chr1:53392781 SCP2 -0.44 -6.96 -0.36 1.88e-11 Monocyte count; CRC trans rs629535 0.679 rs62511660 chr8:70157089 G/A cg21567404 chr3:27674614 NA -0.9 -13.02 -0.58 1.56e-31 Dupuytren's disease; CRC cis rs9478638 0.507 rs2184406 chr6:155629678 T/C cg07943832 chr6:155568918 TIAM2 -0.59 -7.64 -0.39 2.33e-13 Electroencephalogram traits; CRC cis rs7487075 0.930 rs4076248 chr12:46833605 C/T cg22049899 chr12:47219821 SLC38A4 0.31 6.21 0.32 1.58e-9 Itch intensity from mosquito bite; CRC cis rs4243830 0.850 rs57203351 chr1:6601319 T/C cg05709478 chr1:6581295 PLEKHG5 0.64 7.44 0.38 8.99e-13 Body mass index; CRC cis rs910316 1.000 rs12590452 chr14:75548756 T/C cg08847533 chr14:75593920 NEK9 0.95 18.79 0.72 5e-54 Height; CRC trans rs2797160 1.000 rs4897153 chr6:126003403 A/G cg05039488 chr6:79577232 IRAK1BP1 -0.49 -7.2 -0.37 4.18e-12 Endometrial cancer; CRC cis rs7618915 0.533 rs35107891 chr3:52613656 G/C cg05573699 chr3:52720067 GNL3;PBRM1 -0.44 -6.23 -0.32 1.44e-9 Bipolar disorder; CRC cis rs4731207 0.596 rs7810643 chr7:124611410 G/A cg23710748 chr7:124431027 NA -0.39 -6.07 -0.32 3.56e-9 Cutaneous malignant melanoma; CRC cis rs9311676 0.632 rs56026131 chr3:58422483 C/G cg06643156 chr3:58380774 PXK 0.43 6.53 0.34 2.5e-10 Systemic lupus erythematosus; CRC cis rs2204008 0.837 rs2892296 chr12:37969785 C/T cg26384229 chr12:38710491 ALG10B -0.63 -9.75 -0.47 7e-20 Bladder cancer; CRC cis rs76878669 0.561 rs12416747 chr11:66135614 A/G cg24851651 chr11:66362959 CCS -0.39 -6.77 -0.35 6.08e-11 Educational attainment (years of education); CRC cis rs2013441 0.613 rs888424 chr17:19985427 C/T cg13482628 chr17:19912719 NA 0.38 5.89 0.31 9.43e-9 Obesity-related traits; CRC cis rs4713118 0.824 rs742046 chr6:27739254 A/G cg02683197 chr6:28174875 NA 0.69 9.04 0.45 1.38e-17 Parkinson's disease; CRC cis rs9900062 0.546 rs2428352 chr17:62694738 C/T cg02598441 chr17:62777298 LOC146880 0.54 7.31 0.37 2.09e-12 QT interval; CRC cis rs875971 0.755 rs76288834 chr7:66069802 G/A cg11764359 chr7:65958608 NA -0.6 -8.77 -0.44 9.68e-17 Aortic root size; CRC cis rs7626444 0.625 rs1798634 chr3:196474287 G/A cg12930392 chr3:196481615 PAK2 0.4 7.05 0.36 1.07e-11 Monocyte count; CRC cis rs7584330 0.657 rs10190310 chr2:238352282 C/T cg14458575 chr2:238380390 NA 0.67 11.52 0.54 5.1e-26 Prostate cancer; CRC cis rs6502050 0.799 rs9675196 chr17:80096655 C/T cg19223190 chr17:80058835 NA 0.42 6.63 0.34 1.37e-10 Life satisfaction; CRC cis rs910316 0.967 rs10142770 chr14:75525449 G/A cg03030879 chr14:75389066 RPS6KL1 -0.47 -7.28 -0.37 2.49e-12 Height; CRC cis rs2836974 0.568 rs2836969 chr21:40648265 G/A cg17971929 chr21:40555470 PSMG1 -0.72 -11.15 -0.52 1.05e-24 Cognitive function; CRC cis rs2303759 0.918 rs2288480 chr19:49867016 C/G cg22133161 chr19:49891603 CCDC155 0.53 7.37 0.38 1.41e-12 Multiple sclerosis; CRC cis rs9828933 0.577 rs832194 chr3:63857071 G/A cg16258503 chr3:63850278 ATXN7;THOC7 0.77 9.0 0.44 1.87e-17 Type 2 diabetes; CRC cis rs4523957 0.855 rs216212 chr17:2134214 T/C cg16513277 chr17:2031491 SMG6 0.52 8.69 0.43 1.7e-16 Autism spectrum disorder or schizophrenia;Schizophrenia; CRC cis rs2836950 0.565 rs7276046 chr21:40581293 T/C cg11890956 chr21:40555474 PSMG1 -0.69 -10.32 -0.49 8.35e-22 Menarche (age at onset); CRC cis rs7917772 0.619 rs2801050 chr10:104509393 T/A cg04362960 chr10:104952993 NT5C2 -0.47 -5.98 -0.31 5.68e-9 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC cis rs10924970 0.649 rs6673756 chr1:235412134 G/A cg09010748 chr1:235293032 TOMM20 -0.42 -5.77 -0.3 1.86e-8 Asthma; CRC cis rs1005277 0.505 rs7099777 chr10:38183569 A/C cg00409905 chr10:38381863 ZNF37A 0.63 10.29 0.49 1.04e-21 Extrinsic epigenetic age acceleration; CRC cis rs2898681 0.521 rs115874483 chr4:53728272 G/A cg00791764 chr4:53727839 RASL11B 0.5 6.71 0.35 8.27e-11 Optic nerve measurement (cup area); CRC cis rs2976388 0.647 rs2164307 chr8:143788831 A/T cg12516270 chr8:143859308 LYNX1 0.42 7.54 0.38 4.55e-13 Urinary tract infection frequency; CRC cis rs2243480 1.000 rs2257790 chr7:65600450 C/T cg18252515 chr7:66147081 NA -1.25 -14.84 -0.63 1.63e-38 Diabetic kidney disease; CRC cis rs4604732 0.536 rs4433437 chr1:247636580 A/T cg02104434 chr1:247694406 LOC148824;OR2C3 0.55 8.03 0.4 1.77e-14 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CRC cis rs514406 0.755 rs10888754 chr1:53228751 C/G cg08859206 chr1:53392774 SCP2 0.42 6.76 0.35 6.46e-11 Monocyte count; CRC cis rs9322193 0.962 rs2151912 chr6:150152908 A/G cg07701084 chr6:150067640 NUP43 0.46 6.29 0.33 1.04e-9 Lung cancer; CRC cis rs8051149 0.688 rs3815559 chr16:87871366 G/C cg01412419 chr16:87856264 NA 0.52 7.11 0.37 7.18e-12 Blood metabolite levels; CRC cis rs2710642 0.886 rs10153716 chr2:63007059 A/G cg17519650 chr2:63277830 OTX1 -0.43 -6.0 -0.31 5.24e-9 LDL cholesterol levels;LDL cholesterol; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg01213445 chr15:91537450 PRC1 -0.39 -6.05 -0.32 3.84e-9 Myopia (pathological); CRC cis rs514406 0.893 rs1242326 chr1:53399104 C/A cg25767906 chr1:53392781 SCP2 -0.5 -8.04 -0.41 1.58e-14 Monocyte count; CRC cis rs951366 0.789 rs7536483 chr1:205718858 A/T cg14893161 chr1:205819251 PM20D1 0.82 13.01 0.58 1.61e-31 Menarche (age at onset); CRC cis rs4819052 0.807 rs1075788 chr21:46666564 T/G cg02159808 chr21:46707872 POFUT2;LOC642852 0.49 6.43 0.33 4.41e-10 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs11168936 1.000 rs11168936 chr12:49645240 A/G cg14846292 chr12:49726500 C1QL4 -0.34 -5.64 -0.3 3.65e-8 Cancer (pleiotropy); CRC cis rs1451375 1.000 rs1966839 chr7:50627101 T/C cg14593290 chr7:50529359 DDC 0.55 7.71 0.39 1.52e-13 Malaria; CRC cis rs1707322 1.000 rs785478 chr1:46491635 C/T cg06784218 chr1:46089804 CCDC17 -0.52 -9.34 -0.46 1.52e-18 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs7044106 0.762 rs10491783 chr9:123450155 C/G cg09586646 chr9:123605570 PSMD5;LOC253039 0.6 8.83 0.44 6.35e-17 Hip circumference adjusted for BMI; CRC cis rs889398 0.770 rs8052225 chr16:69883653 G/A cg00738113 chr16:70207722 CLEC18C -0.36 -6.18 -0.32 1.92e-9 Body mass index; CRC cis rs2842992 0.724 rs2273827 chr6:160211339 C/A cg16489826 chr6:160211363 TCP1;MRPL18 0.61 8.99 0.44 1.94e-17 Age-related macular degeneration (geographic atrophy); CRC cis rs4713118 0.869 rs4713121 chr6:27722064 T/C cg25164649 chr6:28176230 NA 0.7 8.96 0.44 2.38e-17 Parkinson's disease; CRC cis rs10193935 0.901 rs13429697 chr2:42529818 C/T cg27598129 chr2:42591480 NA -0.67 -7.73 -0.39 1.28e-13 Colonoscopy-negative controls vs population controls; CRC cis rs853679 0.723 rs9366718 chr6:28205502 A/T cg02683197 chr6:28174875 NA 0.65 6.58 0.34 1.81e-10 Depression; CRC cis rs11229555 1.000 rs2298608 chr11:58404467 A/G cg15696309 chr11:58395628 NA 0.93 13.18 0.59 3.69e-32 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; CRC cis rs6088590 0.965 rs6058108 chr20:33288655 A/G cg24642439 chr20:33292090 TP53INP2 0.59 10.64 0.51 6.54e-23 Coronary artery disease; CRC cis rs9462846 0.881 rs34498470 chr6:42879551 C/T cg05552183 chr6:42928497 GNMT 0.45 5.71 0.3 2.51e-8 Blood protein levels; CRC cis rs4478137 0.824 rs10857353 chr4:164215835 A/G cg06758707 chr4:164254230 NPY1R -0.45 -6.97 -0.36 1.76e-11 Subjective well-being (multi-trait analysis);Subjective well-being; CRC cis rs10450586 0.932 rs7483162 chr11:27316394 A/G cg10370305 chr11:27303972 NA 0.35 5.69 0.3 2.76e-8 Total body bone mineral density; CRC cis rs8078723 0.668 rs3859191 chr17:38128714 G/A cg17467752 chr17:38218738 THRA 0.62 9.61 0.47 1.89e-19 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); CRC cis rs394563 0.591 rs237012 chr6:149729198 T/C cg16235748 chr6:149772707 ZC3H12D -0.37 -6.79 -0.35 5.14e-11 Dupuytren's disease; CRC cis rs9911578 1.000 rs2009948 chr17:56611920 A/C cg05425664 chr17:57184151 TRIM37 0.51 8.17 0.41 6.81e-15 Intelligence (multi-trait analysis); CRC cis rs11758351 1.000 rs3757135 chr6:26200707 G/A cg22723502 chr6:26240528 HIST1H4F -0.39 -5.92 -0.31 8.11e-9 Gout;Renal underexcretion gout; CRC cis rs6921919 0.583 rs6928771 chr6:28375209 T/G cg21251018 chr6:28226885 NKAPL 0.4 6.12 0.32 2.61e-9 Autism spectrum disorder or schizophrenia; CRC cis rs400736 0.562 rs7551900 chr1:8178526 A/C cg25007680 chr1:8021821 PARK7 -0.46 -6.1 -0.32 3.03e-9 Response to antidepressants and depression; CRC cis rs7786808 0.741 rs11767875 chr7:158228923 A/G cg01191920 chr7:158217561 PTPRN2 -0.91 -17.89 -0.7 1.83e-50 Obesity-related traits; CRC cis rs3772130 1.000 rs17691170 chr3:121357626 G/C cg20356878 chr3:121714668 ILDR1 0.49 7.65 0.39 2.22e-13 Cognitive performance; CRC cis rs67311347 0.869 rs9832311 chr3:40381322 A/T cg09455208 chr3:40491958 NA 0.45 8.97 0.44 2.29e-17 Renal cell carcinoma; CRC cis rs2836974 0.897 rs8132295 chr21:40527774 A/G cg11890956 chr21:40555474 PSMG1 -1.11 -21.27 -0.76 9.42e-64 Cognitive function; CRC cis rs12681287 0.571 rs13254675 chr8:87353594 C/T cg27223183 chr8:87520930 FAM82B -0.52 -6.9 -0.36 2.72e-11 Caudate activity during reward; CRC cis rs7216064 1.000 rs62084238 chr17:65856573 T/A cg12091567 chr17:66097778 LOC651250 -0.67 -7.69 -0.39 1.67e-13 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CRC trans rs3942852 0.774 rs10838812 chr11:48186924 T/C cg15704280 chr7:45808275 SEPT13 -0.75 -9.3 -0.46 2.07e-18 Acute lymphoblastic leukemia (childhood); CRC cis rs2880765 0.527 rs35184622 chr15:86073035 A/G cg10818794 chr15:86012489 AKAP13 -0.45 -6.46 -0.34 3.82e-10 Coronary artery disease; CRC cis rs7666738 0.830 rs1405767 chr4:98965295 T/C cg05340658 chr4:99064831 C4orf37 0.61 9.45 0.46 6.55e-19 Colonoscopy-negative controls vs population controls; CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg20540378 chr5:149340137 SLC26A2 -0.52 -6.25 -0.33 1.29e-9 Diisocyanate-induced asthma; CRC cis rs769267 0.929 rs2905421 chr19:19457908 G/T cg03709012 chr19:19516395 GATAD2A 0.66 9.87 0.48 2.72e-20 Tonsillectomy; CRC cis rs9311474 0.508 rs6805156 chr3:52609362 T/C cg10802521 chr3:52805072 NEK4 -0.58 -9.23 -0.45 3.45e-18 Electroencephalogram traits; CRC trans rs1005277 0.579 rs176838 chr10:38371899 A/T cg11292332 chr7:45801988 SEPT13 0.34 6.07 0.32 3.45e-9 Extrinsic epigenetic age acceleration; CRC trans rs783540 1.000 rs6603033 chr15:83335875 A/C cg18393722 chr15:85113863 UBE2QP1 0.38 6.32 0.33 8.58e-10 Schizophrenia; CRC cis rs7932354 0.536 rs7929294 chr11:46776176 T/C cg19486271 chr11:47235900 DDB2 -0.43 -6.51 -0.34 2.78e-10 Bone mineral density (hip);Bone mineral density; CRC cis rs4363385 0.818 rs1334848 chr1:153004721 A/T cg25856811 chr1:152973957 SPRR3 -0.25 -6.93 -0.36 2.19e-11 Inflammatory skin disease; CRC trans rs11098499 0.604 rs2389886 chr4:120570422 C/T cg25214090 chr10:38739885 LOC399744 0.56 8.26 0.41 3.5e-15 Corneal astigmatism; CRC cis rs11155671 0.530 rs1334510 chr6:150201179 A/G cg07701084 chr6:150067640 NUP43 0.5 7.24 0.37 3.15e-12 Testicular germ cell tumor; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg19463885 chr2:242626846 DTYMK 0.45 6.34 0.33 7.75e-10 Response to antipsychotic treatment; CRC cis rs4727027 0.901 rs66800495 chr7:148763702 T/C cg23583168 chr7:148888333 NA -0.86 -14.54 -0.63 2.36e-37 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC cis rs644799 0.526 rs534973 chr11:95633624 A/T cg03916912 chr11:95522834 CEP57;FAM76B 0.71 11.9 0.55 2.17e-27 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs1799949 1.000 rs12944597 chr17:41187684 A/C cg19454999 chr17:41278357 BRCA1;NBR2 0.52 7.75 0.39 1.14e-13 Menopause (age at onset); CRC cis rs7833986 1.000 rs66796428 chr8:57094797 G/A cg23139584 chr8:56987506 RPS20;SNORD54 0.61 7.54 0.38 4.64e-13 Height; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg00711773 chr3:40351057 EIF1B 0.41 6.53 0.34 2.45e-10 Liver disease severity in Alagille syndrome; CRC cis rs17155006 0.746 rs402264 chr7:107748337 G/A cg05962710 chr7:107745446 LAMB4 -0.41 -7.44 -0.38 8.61e-13 Pneumococcal bacteremia; CRC cis rs4074493 1.000 rs10864655 chr1:231172810 A/G cg22172038 chr1:231176991 FAM89A 0.35 6.03 0.32 4.29e-9 Carotid plaque burden (smoking interaction); CRC cis rs7085104 0.514 rs284855 chr10:104574422 A/G cg04362960 chr10:104952993 NT5C2 -0.56 -8.35 -0.42 1.93e-15 Immature fraction of reticulocytes;Schizophrenia; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg03640568 chr22:38902623 DDX17 0.44 6.14 0.32 2.34e-9 Response to antipsychotic treatment; CRC cis rs10751667 1.000 rs6597972 chr11:928402 C/T cg01483505 chr11:975446 AP2A2 0.4 6.05 0.32 4e-9 Alzheimer's disease (late onset); CRC cis rs769267 0.929 rs2965180 chr19:19491973 T/C cg01262667 chr19:19385393 TM6SF2 -0.38 -6.39 -0.33 5.68e-10 Tonsillectomy; CRC cis rs9914988 0.667 rs11655019 chr17:27255191 T/C cg16670446 chr17:27188758 MIR451;MIR144 0.49 6.25 0.33 1.27e-9 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg14588027 chr1:212872986 BATF3 0.41 6.37 0.33 6.51e-10 Liver disease severity in Alagille syndrome; CRC cis rs883565 0.655 rs1608728 chr3:39089560 C/T cg01426195 chr3:39028469 NA -0.54 -8.7 -0.43 1.61e-16 Handedness; CRC cis rs9311676 0.656 rs4681679 chr3:58332068 A/G cg06643156 chr3:58380774 PXK -0.44 -6.8 -0.35 4.99e-11 Systemic lupus erythematosus; CRC trans rs1455244 0.700 rs7229302 chr18:11508904 G/T cg15672331 chr15:85923765 AKAP13 0.39 6.16 0.32 2.15e-9 Schizophrenia; CRC cis rs17711722 0.675 rs6947132 chr7:65273495 G/A cg18876405 chr7:65276391 NA -0.67 -12.17 -0.56 2.12e-28 Calcium levels; CRC cis rs763121 0.819 rs6001205 chr22:39100264 T/A cg06022373 chr22:39101656 GTPBP1 0.79 12.32 0.56 6.2e-29 Menopause (age at onset); CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg11861986 chr17:3572125 TMEM93;TAX1BP3 0.46 6.46 0.34 3.67e-10 Anxiety disorder; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg17047865 chr12:57824889 NA 0.44 6.29 0.33 1.01e-9 Anxiety disorder; CRC cis rs1799949 1.000 rs11652332 chr17:41295489 G/A cg05368731 chr17:41323189 NBR1 0.67 10.01 0.48 9.22e-21 Menopause (age at onset); CRC cis rs2153535 0.584 rs62395678 chr6:8371689 C/T cg07606381 chr6:8435919 SLC35B3 -0.64 -9.92 -0.48 1.82e-20 Motion sickness; CRC cis rs4588572 0.644 rs10061149 chr5:77744201 G/A cg11446398 chr5:77624930 NA 0.42 6.01 0.31 5.01e-9 Triglycerides; CRC cis rs3096299 0.933 rs2965823 chr16:89454924 G/A cg01788221 chr16:89496183 ANKRD11 -0.44 -6.81 -0.35 4.6e-11 Multiple myeloma (IgH translocation); CRC cis rs754466 0.651 rs11815015 chr10:79625482 C/T cg26805224 chr10:79626177 DLG5 -0.56 -8.34 -0.42 2.12e-15 Liver enzyme levels (gamma-glutamyl transferase); CRC trans rs9858542 1.000 rs9822268 chr3:49719729 G/A cg21659725 chr3:3221576 CRBN -0.72 -9.53 -0.47 3.66e-19 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs9914988 0.725 rs66531973 chr17:27125993 G/T cg07195577 chr17:27052828 TLCD1 0.42 6.06 0.32 3.63e-9 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs11031096 0.782 rs7130580 chr11:4169301 G/A cg18678763 chr11:4115507 RRM1 -0.44 -7.64 -0.39 2.34e-13 Mean corpuscular volume;Mean corpuscular hemoglobin; CRC cis rs11212617 0.967 rs227068 chr11:108210109 A/G cg01991180 chr11:108092276 ATM;NPAT 0.41 5.99 0.31 5.41e-9 Response to metformin in type 2 diabetes (glycemic); CRC cis rs6460942 0.915 rs7803051 chr7:12306904 A/T cg20607287 chr7:12443886 VWDE -0.48 -6.32 -0.33 8.6e-10 Coronary artery disease; CRC cis rs4880487 0.888 rs10794731 chr10:1251905 T/A cg03183215 chr10:1252341 ADARB2 -0.3 -6.32 -0.33 8.35e-10 Migraine; CRC cis rs929354 0.685 rs1808217 chr7:157002741 T/C cg16102536 chr7:156981717 UBE3C 0.4 6.77 0.35 5.75e-11 Body mass index; CRC cis rs4409675 0.556 rs2064710 chr1:28231154 G/A cg23691781 chr1:28212827 C1orf38 0.31 7.17 0.37 4.98e-12 Corneal astigmatism; CRC cis rs1577917 1.000 rs12213740 chr6:86656733 A/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.51 -6.77 -0.35 5.76e-11 Response to antipsychotic treatment; CRC cis rs12618769 0.652 rs11537554 chr2:99216531 A/G cg18455616 chr2:99124870 INPP4A 0.35 5.82 0.31 1.41e-8 Bipolar disorder; CRC cis rs9443189 1.000 rs1280048 chr6:76529583 C/T cg01950844 chr6:76311363 SENP6 0.58 6.9 0.36 2.63e-11 Prostate cancer; CRC cis rs17376456 0.877 rs10061080 chr5:93420559 A/G cg25358565 chr5:93447407 FAM172A 0.97 10.46 0.5 2.7e-22 Diabetic retinopathy; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg08659621 chr20:48552817 RNF114 0.5 6.51 0.34 2.8e-10 Thyroid stimulating hormone; CRC cis rs11098499 0.874 rs10022508 chr4:120115228 A/G cg09307838 chr4:120376055 NA 0.61 8.96 0.44 2.39e-17 Corneal astigmatism; CRC cis rs853679 0.760 rs9468317 chr6:28198456 A/G cg21251018 chr6:28226885 NKAPL 0.51 6.21 0.32 1.58e-9 Depression; CRC cis rs1375194 0.606 rs17657783 chr2:33814590 A/G cg04131969 chr2:33951647 MYADML -0.5 -7.37 -0.38 1.36e-12 Response to antidepressants in depression; CRC cis rs6933660 0.800 rs9383893 chr6:151757327 T/C cg10883421 chr6:151773342 RMND1;C6orf211 0.74 12.79 0.58 1.1e-30 Menarche (age at onset); CRC cis rs501120 0.584 rs674746 chr10:44733522 A/T cg09554077 chr10:44749378 NA 0.64 7.06 0.36 9.84e-12 Coronary artery disease;Coronary heart disease; CRC cis rs2115630 0.875 rs8039472 chr15:85361644 A/G cg11189052 chr15:85197271 WDR73 -0.65 -10.71 -0.51 3.62e-23 P wave terminal force; CRC trans rs2727020 0.595 rs10466496 chr11:49501514 C/T cg15704280 chr7:45808275 SEPT13 -0.95 -18.2 -0.71 1.11e-51 Coronary artery disease; CRC cis rs67311347 0.911 rs58282210 chr3:40417943 C/T cg24209194 chr3:40518798 ZNF619 0.39 5.71 0.3 2.48e-8 Renal cell carcinoma; CRC cis rs853679 0.517 rs6941992 chr6:28106141 T/C cg12172441 chr6:28176163 NA 0.62 7.4 0.38 1.17e-12 Depression; CRC cis rs34375054 0.526 rs2343638 chr12:125677122 G/C cg02766259 chr12:125626809 AACS -0.45 -7.72 -0.39 1.42e-13 Post bronchodilator FEV1/FVC ratio; CRC cis rs3849570 0.732 rs11715625 chr3:81875938 A/T cg07356753 chr3:81810745 GBE1 -0.6 -8.08 -0.41 1.22e-14 Waist circumference;Body mass index; CRC cis rs2839186 0.609 rs2839189 chr21:47694357 C/T cg00815214 chr21:47717953 NA 0.41 6.88 0.35 3.09e-11 Testicular germ cell tumor; CRC cis rs2204008 0.715 rs12368462 chr12:38336116 C/G cg26384229 chr12:38710491 ALG10B 0.68 9.44 0.46 7.19e-19 Bladder cancer; CRC cis rs6951245 0.554 rs2070118 chr7:1132505 G/A cg03188948 chr7:1209495 NA 0.54 6.31 0.33 8.88e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs274567 0.501 rs581968 chr5:131710202 G/A cg11843238 chr5:131593191 PDLIM4 -0.43 -7.33 -0.37 1.86e-12 Blood metabolite levels; CRC cis rs7493 1.000 rs7493 chr7:95034775 C/G cg07404485 chr7:94953653 PON1 0.45 5.88 0.31 9.87e-9 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs9487051 1.000 rs1008084 chr6:109626965 G/A cg01475377 chr6:109611718 NA -0.44 -7.86 -0.4 5.54e-14 Reticulocyte fraction of red cells; CRC cis rs1538970 0.962 rs2487442 chr1:45857176 C/G cg05343316 chr1:45956843 TESK2 -0.65 -9.06 -0.45 1.17e-17 Platelet count; CRC trans rs2732480 0.500 rs2732461 chr12:48692802 C/A cg05117785 chr10:94050880 CPEB3;MARCH5 0.46 6.07 0.32 3.48e-9 Hemoglobin concentration;Red blood cell count;Hematocrit; CRC cis rs79387448 0.810 rs76229479 chr2:103123912 A/C cg21010569 chr2:103233596 NA 0.54 5.91 0.31 8.74e-9 Gut microbiota (bacterial taxa); CRC cis rs11212617 1.000 rs573890 chr11:108251363 C/G cg01991180 chr11:108092276 ATM;NPAT -0.39 -5.72 -0.3 2.44e-8 Response to metformin in type 2 diabetes (glycemic); CRC cis rs644799 0.965 rs534488 chr11:95562327 G/A cg03916912 chr11:95522834 CEP57;FAM76B 0.95 18.38 0.71 2.03e-52 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs477895 0.713 rs1059440 chr11:63991801 C/T cg04317338 chr11:64019027 PLCB3 -0.64 -7.95 -0.4 2.99e-14 Mean platelet volume; CRC cis rs7618915 0.571 rs2289249 chr3:52597664 G/A cg07507251 chr3:52567010 NT5DC2 0.46 6.73 0.35 7.48e-11 Bipolar disorder; CRC cis rs6456156 0.774 rs1012657 chr6:167525142 A/C cg07513332 chr6:167530253 CCR6 -0.4 -7.14 -0.37 5.84e-12 Primary biliary cholangitis; CRC cis rs853679 0.517 rs56310871 chr6:28044482 A/G cg12963246 chr6:28129442 ZNF389 0.47 5.61 0.3 4.26e-8 Depression; CRC cis rs10206020 0.921 rs10177509 chr2:1568536 T/C cg26248373 chr2:1572462 NA -0.86 -12.74 -0.57 1.68e-30 IgG glycosylation; CRC cis rs10751667 1.000 rs12798036 chr11:947585 T/C cg23136738 chr11:925521 AP2A2 -0.5 -8.2 -0.41 5.64e-15 Alzheimer's disease (late onset); CRC trans rs11088226 0.681 rs1015047 chr21:33949423 A/G cg09050820 chr6:167586206 TCP10L2 0.92 9.75 0.47 6.58e-20 Gastritis; CRC trans rs17126268 0.502 rs2185428 chr1:102880112 A/C cg18468354 chr14:36993517 NA 0.38 6.12 0.32 2.65e-9 Glomerular filtration rate; CRC trans rs1455244 0.700 rs7229302 chr18:11508904 G/T cg13770088 chr11:32851361 PRRG4 0.4 6.21 0.32 1.56e-9 Schizophrenia; CRC cis rs782590 0.607 rs2061032 chr2:55679490 T/C cg18811423 chr2:55921094 PNPT1 0.58 8.58 0.43 3.93e-16 Metabolic syndrome; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg18268492 chr10:99185986 PGAM1 0.39 6.41 0.33 5.11e-10 Liver disease severity in Alagille syndrome; CRC cis rs16852403 0.548 rs2225586 chr1:178204132 C/T cg00404053 chr1:178313656 RASAL2 0.48 6.35 0.33 7.32e-10 Childhood ear infection; CRC cis rs7246657 0.714 rs12972195 chr19:37752505 T/C cg23950597 chr19:37808831 NA -0.49 -5.86 -0.31 1.14e-8 Coronary artery calcification; CRC cis rs1153858 1.000 rs59889118 chr15:45618730 G/A cg14582100 chr15:45693742 SPATA5L1 0.28 5.61 0.3 4.23e-8 Homoarginine levels; CRC cis rs7493 0.950 rs7785846 chr7:95033841 C/T cg01874867 chr7:94954059 PON1 -0.49 -6.35 -0.33 7e-10 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs78545713 0.649 rs74928264 chr6:26224343 C/G cg01420254 chr6:26195488 NA 0.66 5.87 0.31 1.04e-8 Iron status biomarkers (total iron binding capacity); CRC cis rs6541297 0.941 rs2144299 chr1:230280366 A/G cg05784532 chr1:230284198 GALNT2 0.48 6.24 0.33 1.32e-9 Coronary artery disease; CRC cis rs10979 1.000 rs9376763 chr6:143887386 C/T cg25407410 chr6:143891975 LOC285740 -0.83 -13.54 -0.6 1.73e-33 Hypospadias; CRC cis rs875971 0.895 rs10447522 chr7:65796074 A/G cg00343986 chr7:65444356 GUSB -0.45 -6.17 -0.32 2.05e-9 Aortic root size; CRC cis rs10504229 1.000 rs67705655 chr8:58177688 G/A cg05313129 chr8:58192883 C8orf71 -0.47 -6.99 -0.36 1.49e-11 Developmental language disorder (linguistic errors); CRC cis rs10927875 0.722 rs6660685 chr1:16346988 A/G cg21385522 chr1:16154831 NA 0.6 7.53 0.38 4.86e-13 Dilated cardiomyopathy; CRC trans rs925098 0.577 rs2724470 chr4:17996046 A/G cg10708793 chr17:40264626 DHX58 -0.43 -6.35 -0.33 7.2e-10 Birth weight;Height; CRC cis rs74377301 1 rs74377301 chr7:123232495 C/T cg03229431 chr7:123269106 ASB15 -0.61 -8.94 -0.44 2.95e-17 Left ventricular obstructive tract defect (inherited effect); CRC cis rs7666738 0.753 rs13120995 chr4:98972762 A/G cg17366294 chr4:99064904 C4orf37 0.44 7.44 0.38 8.98e-13 Colonoscopy-negative controls vs population controls; CRC cis rs17234274 0.644 rs10833967 chr11:23214978 G/A cg05245346 chr11:23248277 NA 0.36 5.93 0.31 7.53e-9 Cancer; CRC cis rs28489187 0.706 rs66811655 chr1:85831544 T/G cg17737388 chr1:85724454 C1orf52 0.38 5.7 0.3 2.67e-8 Asymmetrical dimethylarginine levels;Serum dimethylarginine levels (asymmetric/symetric ratio); CRC cis rs758324 0.773 rs10069521 chr5:131174215 A/G cg25547332 chr5:131281432 NA 0.37 5.86 0.31 1.14e-8 Alzheimer's disease in APOE e4- carriers; CRC cis rs3858526 0.916 rs11039551 chr11:5930773 C/T cg02574844 chr11:5959923 NA -0.43 -6.11 -0.32 2.77e-9 DNA methylation (variation); CRC cis rs10504229 0.683 rs73603874 chr8:58108340 G/A cg02725872 chr8:58115012 NA -0.66 -11.36 -0.53 1.84e-25 Developmental language disorder (linguistic errors); CRC cis rs6860806 0.661 rs6871350 chr5:131580220 A/G cg04518342 chr5:131593106 PDLIM4 0.46 8.48 0.42 7.92e-16 Breast cancer; CRC cis rs13191362 0.938 rs13192618 chr6:163132822 T/C cg06582575 chr6:163149167 PACRG;PARK2 0.93 12.35 0.56 4.81e-29 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs2836974 0.897 rs2836944 chr21:40593539 G/A cg06238570 chr21:40685208 BRWD1 0.78 10.78 0.51 2.09e-23 Cognitive function; CRC cis rs9926296 0.605 rs3743859 chr16:89846050 A/G cg04287289 chr16:89883240 FANCA -0.8 -14.65 -0.63 9.59e-38 Vitiligo; CRC cis rs1395 0.848 rs6716850 chr2:27525350 G/A cg23587288 chr2:27483067 SLC30A3 -0.34 -5.75 -0.3 2e-8 Blood metabolite levels; CRC cis rs7605827 0.930 rs4668444 chr2:15515642 C/T cg19274914 chr2:15703543 NA 0.4 6.03 0.32 4.33e-9 Educational attainment (years of education); CRC cis rs910316 0.737 rs175045 chr14:75475275 A/C cg03030879 chr14:75389066 RPS6KL1 0.41 5.7 0.3 2.71e-8 Height; CRC cis rs929354 0.742 rs2107863 chr7:156963731 T/C cg17757837 chr7:157058334 UBE3C 0.74 12.39 0.56 3.31e-29 Body mass index; CRC cis rs9649213 0.593 rs3823740 chr7:97957104 T/G cg24562669 chr7:97807699 LMTK2 0.44 7.29 0.37 2.33e-12 Prostate cancer (SNP x SNP interaction); CRC cis rs8072100 0.701 rs10163469 chr17:45687767 G/A cg08085267 chr17:45401833 C17orf57 0.61 9.6 0.47 2.11e-19 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs362272 0.545 rs2239725 chr4:3305739 C/T cg11522145 chr4:3412961 RGS12 -0.42 -6.42 -0.33 4.87e-10 Serum sulfate level; CRC cis rs11763147 1 rs11763147 chr7:65326821 C/T cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.45 -6.8 -0.35 4.84e-11 Corneal structure; CRC trans rs867743 0.512 rs6471810 chr8:60686056 A/C cg01502296 chr2:241512254 RNPEPL1 0.44 5.97 0.31 6.23e-9 Schizophrenia; CRC cis rs6502050 0.871 rs8066137 chr17:80074316 T/C cg25804541 chr17:80189381 SLC16A3 0.32 6.13 0.32 2.51e-9 Life satisfaction; CRC cis rs10193935 0.901 rs13384404 chr2:42601147 G/T cg27598129 chr2:42591480 NA -0.68 -7.76 -0.39 1.08e-13 Colonoscopy-negative controls vs population controls; CRC cis rs4819052 0.851 rs2838857 chr21:46681000 A/G cg19498844 chr21:46707878 POFUT2;LOC642852 0.74 10.62 0.51 7.49e-23 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs7615952 0.641 rs60839048 chr3:125807938 G/A cg15145296 chr3:125709740 NA -0.57 -6.72 -0.35 8.16e-11 Blood pressure (smoking interaction); CRC cis rs1003719 0.591 rs9636914 chr21:38589732 A/G cg10648535 chr21:38446584 PIGP;TTC3 0.43 5.93 0.31 7.65e-9 Eye color traits; CRC cis rs9463078 0.547 rs764396 chr6:44710691 C/G cg25276700 chr6:44698697 NA 0.31 7.79 0.39 8.87e-14 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; CRC cis rs9549367 0.713 rs3024769 chr13:113825601 A/C cg00898013 chr13:113819073 PROZ 0.54 7.98 0.4 2.5e-14 Platelet distribution width; CRC cis rs861020 0.959 rs658860 chr1:209990549 C/T cg05527609 chr1:210001259 C1orf107 0.98 12.39 0.56 3.49e-29 Orofacial clefts; CRC trans rs4650994 0.525 rs2493860 chr1:178541492 A/G cg05059571 chr16:84539110 KIAA1609 -0.61 -8.32 -0.42 2.45e-15 HDL cholesterol levels;HDL cholesterol; CRC cis rs1707322 0.716 rs28370457 chr1:46172062 C/T cg06784218 chr1:46089804 CCDC17 0.65 12.15 0.56 2.54e-28 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg09898070 chr2:48009866 MSH6 0.39 6.43 0.33 4.45e-10 Obesity-related traits; CRC cis rs1707322 1.000 rs2458400 chr1:46530798 C/T cg03146154 chr1:46216737 IPP -0.51 -6.93 -0.36 2.27e-11 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs9359856 0.564 rs55722352 chr6:90365853 C/T cg13799429 chr6:90582589 CASP8AP2 -0.74 -8.12 -0.41 9.21e-15 Bipolar disorder; CRC cis rs12477438 0.784 rs13407840 chr2:99569928 C/T cg14399236 chr2:99771627 LIPT1;TSGA10 -0.6 -8.25 -0.41 3.89e-15 Chronic sinus infection; CRC cis rs62103177 0.810 rs62103191 chr18:77628769 C/G cg12964065 chr18:77638022 KCNG2 0.66 6.69 0.35 9.56e-11 Opioid sensitivity; CRC cis rs7772486 0.754 rs9373475 chr6:146126419 C/T cg05347473 chr6:146136440 FBXO30 0.38 5.79 0.3 1.6e-8 Lobe attachment (rater-scored or self-reported); CRC trans rs8002861 0.935 rs9533672 chr13:44451180 C/T cg17145862 chr1:211918768 LPGAT1 0.75 14.93 0.64 7.68e-39 Leprosy; CRC cis rs2032447 0.714 rs199739 chr6:25960509 A/C cg17691542 chr6:26056736 HIST1H1C 0.42 5.8 0.3 1.53e-8 Intelligence (multi-trait analysis); CRC cis rs2795502 1.000 rs2795497 chr10:43339475 C/A cg27426351 chr10:43362370 NA -0.6 -7.12 -0.37 6.96e-12 Blood protein levels; CRC cis rs9311676 0.632 rs62258129 chr3:58397187 G/A cg06643156 chr3:58380774 PXK 0.42 6.38 0.33 5.84e-10 Systemic lupus erythematosus; CRC cis rs1153858 1.000 rs56850226 chr15:45633118 T/C cg10760299 chr15:45669010 GATM 0.52 8.27 0.41 3.39e-15 Homoarginine levels; CRC cis rs11758351 1.000 rs17598927 chr6:26184640 C/G cg00620190 chr6:26240307 HIST1H4F 0.48 5.89 0.31 9.69e-9 Gout;Renal underexcretion gout; CRC cis rs853679 0.517 rs9357061 chr6:28051772 A/G cg23161317 chr6:28129485 ZNF389 0.51 6.36 0.33 6.66e-10 Depression; CRC cis rs826838 0.935 rs4583043 chr12:38645147 T/G cg13010199 chr12:38710504 ALG10B 0.43 5.68 0.3 3.01e-8 Heart rate; CRC cis rs6735179 0.958 rs10048704 chr2:1777819 G/C cg19300414 chr2:1746591 PXDN 0.4 6.63 0.34 1.38e-10 Response to antipsychotic treatment; CRC trans rs11026407 0.967 rs7127246 chr11:22060228 C/G cg24671235 chr10:45448095 NA -0.53 -5.99 -0.31 5.38e-9 Plasma thyroid-stimulating hormone levels; CRC cis rs4713118 0.513 rs149975 chr6:27986340 G/A cg02631126 chr6:28058918 ZSCAN12L1 0.24 5.77 0.3 1.8e-8 Parkinson's disease; CRC cis rs7949030 0.626 rs1061093 chr11:62334908 G/C cg13298116 chr11:62369859 EML3;MTA2 0.61 10.84 0.51 1.3e-23 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; CRC cis rs11252926 0.563 rs10795103 chr10:451849 C/A cg16386425 chr10:429943 DIP2C -0.45 -6.94 -0.36 2.06e-11 Psychosis in Alzheimer's disease; CRC trans rs9929218 1.000 rs28450087 chr16:68803726 T/G cg04657470 chr2:198365150 HSPE1;HSPD1 -0.84 -11.93 -0.55 1.64e-27 Colorectal cancer; CRC trans rs7267979 0.932 rs6037125 chr20:25463382 G/A cg17903999 chr18:56338584 MALT1 -0.4 -6.8 -0.35 4.96e-11 Liver enzyme levels (alkaline phosphatase); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg00767560 chr19:19887256 LOC284440 0.47 6.66 0.34 1.16e-10 Response to antipsychotic treatment; CRC cis rs9747201 0.962 rs62079995 chr17:80076624 C/T cg14673194 chr17:80132900 CCDC57 0.49 6.34 0.33 7.73e-10 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs1697139 1.000 rs1705397 chr5:66511062 G/T cg11553311 chr5:66541588 NA -0.46 -7.16 -0.37 5.19e-12 Breast cancer; CRC trans rs10155879 0.505 rs12704265 chr7:86142678 A/G cg22194305 chr4:2264032 MXD4 0.55 6.01 0.31 4.97e-9 Interleukin-4 levels; CRC cis rs11098499 0.954 rs59866101 chr4:120296591 T/G cg24375607 chr4:120327624 NA 0.51 7.86 0.4 5.5e-14 Corneal astigmatism; CRC cis rs2274273 0.870 rs10142547 chr14:55763963 T/C cg23234261 chr14:55582407 NA -0.29 -5.84 -0.31 1.25e-8 Protein biomarker; CRC cis rs704795 0.805 rs1728926 chr2:27612937 A/G cg22903471 chr2:27725779 GCKR -0.37 -6.08 -0.32 3.41e-9 Menopause (age at onset); CRC cis rs13217239 0.646 rs62401067 chr6:27018101 T/A cg12292205 chr6:26970375 C6orf41 0.53 8.68 0.43 1.88e-16 Schizophrenia; CRC cis rs1957429 0.614 rs61012404 chr14:65347649 C/T cg23373153 chr14:65346875 NA -0.65 -5.89 -0.31 9.49e-9 Pediatric areal bone mineral density (radius); CRC cis rs13427251 0.903 rs6746402 chr2:100150443 G/A cg14399236 chr2:99771627 LIPT1;TSGA10 -0.46 -6.67 -0.35 1.06e-10 Chronic sinus infection; CRC cis rs9916302 0.904 rs1077715 chr17:37683548 A/T cg00129232 chr17:37814104 STARD3 -0.55 -8.23 -0.41 4.41e-15 Glomerular filtration rate (creatinine); CRC cis rs7224685 0.569 rs8065660 chr17:4000858 A/G cg09597638 chr17:3907349 NA 0.44 5.66 0.3 3.27e-8 Type 2 diabetes; CRC cis rs9858542 0.953 rs6803222 chr3:49665976 T/G cg03060546 chr3:49711283 APEH -0.52 -7.01 -0.36 1.32e-11 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC trans rs4650994 0.967 rs6681043 chr1:178525957 A/G cg05059571 chr16:84539110 KIAA1609 -0.45 -6.84 -0.35 3.76e-11 HDL cholesterol levels;HDL cholesterol; CRC cis rs727563 0.635 rs5751141 chr22:42107745 A/G cg03806693 chr22:41940476 POLR3H 1.0 11.83 0.55 3.76e-27 Crohn's disease;Inflammatory bowel disease; CRC cis rs208520 0.661 rs207090 chr6:66783963 T/A cg07460842 chr6:66804631 NA -1.09 -15.38 -0.65 1.37e-40 Exhaled nitric oxide output; CRC cis rs644799 1.000 rs472231 chr11:95532166 A/G cg03916912 chr11:95522834 CEP57;FAM76B 0.95 18.15 0.71 1.71e-51 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs9914988 0.887 rs9895625 chr17:27108516 A/G cg16670446 chr17:27188758 MIR451;MIR144 0.55 8.52 0.43 5.75e-16 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs9311474 0.607 rs4475032 chr3:52560021 C/T cg18099408 chr3:52552593 STAB1 -0.52 -9.11 -0.45 8.27e-18 Electroencephalogram traits; CRC trans rs8002861 0.902 rs1445557 chr13:44464827 C/T cg17145862 chr1:211918768 LPGAT1 0.78 15.75 0.66 4.75e-42 Leprosy; CRC cis rs6694672 0.867 rs4915379 chr1:197161428 A/G cg13682187 chr1:196946512 CFHR5 0.48 8.02 0.4 1.89e-14 Asthma; CRC cis rs35110281 0.715 rs2838320 chr21:44995037 A/G cg04455712 chr21:45112962 RRP1B 0.43 8.3 0.42 2.7e-15 Mean corpuscular volume; CRC cis rs4253772 0.591 rs7291444 chr22:46656246 T/G cg24881330 chr22:46731750 TRMU 0.67 7.71 0.39 1.55e-13 LDL cholesterol;Cholesterol, total; CRC cis rs8078723 0.677 rs11658328 chr17:38149236 T/C cg17344932 chr17:38183730 MED24;SNORD124 0.48 7.98 0.4 2.38e-14 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); CRC cis rs7927771 0.524 rs10838777 chr11:47860954 A/C cg20307385 chr11:47447363 PSMC3 0.45 6.62 0.34 1.48e-10 Subjective well-being; CRC cis rs5750830 0.594 rs1010169 chr22:39778167 C/T cg11247378 chr22:39784982 NA 0.41 7.55 0.38 4.34e-13 Intelligence (multi-trait analysis); CRC cis rs9393777 0.513 rs9379893 chr6:26584668 A/G cg12292205 chr6:26970375 C6orf41 0.6 6.77 0.35 6.06e-11 Intelligence (multi-trait analysis); CRC cis rs4665809 0.590 rs13019536 chr2:26526978 C/A cg22920501 chr2:26401640 FAM59B -0.51 -6.8 -0.35 5.04e-11 Gut microbiome composition (summer); CRC cis rs514406 0.861 rs7524476 chr1:53240212 C/T cg08859206 chr1:53392774 SCP2 0.44 6.74 0.35 7.19e-11 Monocyte count; CRC cis rs6840360 0.615 rs62329085 chr4:152470237 G/A cg09659197 chr4:152720779 NA 0.31 5.66 0.3 3.25e-8 Intelligence (multi-trait analysis); CRC cis rs17152411 1.000 rs733401 chr10:126594158 A/T cg07906193 chr10:126599966 NA 0.58 6.52 0.34 2.69e-10 Height; CRC cis rs12701220 0.553 rs13245507 chr7:1163694 C/T cg04498913 chr7:1135747 C7orf50 -0.53 -6.38 -0.33 5.86e-10 Bronchopulmonary dysplasia; CRC cis rs9916302 0.904 rs4795355 chr17:37427382 C/T cg15445000 chr17:37608096 MED1 0.42 9.06 0.45 1.23e-17 Glomerular filtration rate (creatinine); CRC cis rs1448094 0.845 rs7132262 chr12:86346304 C/T cg00310523 chr12:86230176 RASSF9 0.45 7.54 0.38 4.49e-13 Major depressive disorder; CRC cis rs747650 0.892 rs7937101 chr11:47226488 A/G cg03339077 chr11:47165057 C11orf49 0.47 6.83 0.35 4.03e-11 Acne (severe); CRC cis rs6840360 0.606 rs10028035 chr4:152347825 T/G cg09659197 chr4:152720779 NA 0.34 6.67 0.35 1.06e-10 Intelligence (multi-trait analysis); CRC cis rs9894429 1.000 rs4074916 chr17:79579248 G/A cg21984481 chr17:79567631 NPLOC4 0.54 10.01 0.48 9.4499999999999992e-21 Eye color traits; CRC cis rs1008375 1.000 rs2315561 chr4:17679695 C/T cg16339924 chr4:17578868 LAP3 0.5 6.49 0.34 3.24e-10 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs60871478 0.636 rs12532761 chr7:905229 C/T cg05535760 chr7:792225 HEATR2 -0.89 -9.86 -0.48 2.8e-20 Cerebrospinal P-tau181p levels; CRC cis rs6496667 0.865 rs7163144 chr15:90883962 C/T cg04176472 chr15:90893244 GABARAPL3 0.56 6.49 0.34 3.13e-10 Rheumatoid arthritis; CRC cis rs2949837 0.581 rs2960436 chr7:45977282 G/A cg04796162 chr7:45961102 IGFBP3 0.4 6.83 0.35 4.07e-11 Sitting height ratio; CRC cis rs2070488 0.766 rs4679050 chr3:38482007 G/A cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.79 13.72 0.6 3.52e-34 Electrocardiographic conduction measures; CRC cis rs6496667 0.865 rs7163622 chr15:90884791 T/C cg04176472 chr15:90893244 GABARAPL3 0.55 6.41 0.33 5.18e-10 Rheumatoid arthritis; CRC cis rs875971 0.577 rs35072105 chr7:65609817 A/G cg00343986 chr7:65444356 GUSB -0.49 -7.25 -0.37 2.93e-12 Aortic root size; CRC trans rs2280018 0.526 rs2966128 chr16:15153389 G/T cg04146151 chr16:2155961 PKD1 -0.46 -5.97 -0.31 6.01e-9 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid);Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CRC cis rs72717009 0.825 rs10494360 chr1:161475750 G/A cg15358701 chr1:161410459 NA -0.65 -6.88 -0.35 2.96e-11 Rheumatoid arthritis; CRC cis rs490234 0.651 rs13301073 chr9:128284378 G/A cg14078157 chr9:128172775 NA -0.41 -6.73 -0.35 7.51e-11 Mean arterial pressure; CRC cis rs2204008 0.774 rs2387811 chr12:38369794 C/A cg13010199 chr12:38710504 ALG10B 0.45 5.76 0.3 1.96e-8 Bladder cancer; CRC trans rs2303319 0.504 rs12467613 chr2:162603216 G/T cg09481857 chr22:21368659 P2RX6;MGC16703 -0.65 -6.31 -0.33 9.13e-10 Cognitive function; CRC cis rs802075 0.561 rs13198157 chr6:49602760 A/G cg20364632 chr6:49636226 NA 0.34 5.72 0.3 2.41e-8 Bone mineral density (hip) and age at menarche; CRC cis rs6088580 0.608 rs1205342 chr20:32921842 C/T cg24642439 chr20:33292090 TP53INP2 -0.4 -6.77 -0.35 5.9e-11 Glomerular filtration rate (creatinine); CRC cis rs7937682 0.889 rs493810 chr11:111491888 G/T cg09085632 chr11:111637200 PPP2R1B -0.98 -19.21 -0.73 1.09e-55 Primary sclerosing cholangitis; CRC cis rs16975963 0.843 rs17249047 chr19:38336563 A/G cg15135657 chr19:38346511 NA -0.42 -5.72 -0.3 2.34e-8 Longevity; CRC cis rs17433780 0.928 rs10922533 chr1:89456659 C/G cg09516651 chr1:89888402 LOC400759 0.46 6.8 0.35 4.96e-11 Carotid intima media thickness; CRC trans rs7824557 0.505 rs2736313 chr8:11086942 C/T cg06636001 chr8:8085503 FLJ10661 0.56 8.48 0.42 7.63e-16 Retinal vascular caliber; CRC cis rs7647973 1.000 rs6446275 chr3:49466871 A/G cg20833759 chr3:49053208 WDR6;DALRD3 -0.55 -7.99 -0.4 2.33e-14 Menarche (age at onset); CRC cis rs4481887 0.927 rs4341391 chr1:248475720 A/G cg00666640 chr1:248458726 OR2T12 0.47 7.96 0.4 2.88e-14 Common traits (Other); CRC cis rs7044106 0.762 rs4837789 chr9:123426256 G/A cg09586646 chr9:123605570 PSMD5;LOC253039 0.62 8.84 0.44 5.84e-17 Hip circumference adjusted for BMI; CRC trans rs6981523 0.553 rs11783045 chr8:11056175 A/G cg06636001 chr8:8085503 FLJ10661 -0.47 -6.74 -0.35 7.01e-11 Neuroticism; CRC cis rs4363385 0.747 rs2339490 chr1:152984612 A/G cg25856811 chr1:152973957 SPRR3 0.26 7.05 0.36 1.05e-11 Inflammatory skin disease; CRC cis rs10046574 0.831 rs10276768 chr7:135064346 A/G cg27474649 chr7:135195673 CNOT4 0.68 5.72 0.3 2.39e-8 Peripheral arterial disease (traffic-related air pollution interaction); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg00021576 chr1:244211966 NA 0.4 6.75 0.35 6.84e-11 Liver disease severity in Alagille syndrome; CRC cis rs7666738 0.925 rs34423396 chr4:99049031 T/A cg17366294 chr4:99064904 C4orf37 0.47 7.67 0.39 1.96e-13 Colonoscopy-negative controls vs population controls; CRC cis rs9928842 0.882 rs3169330 chr16:75269267 A/G cg08657710 chr16:75258780 CTRB1 -0.59 -6.9 -0.36 2.72e-11 Alcoholic chronic pancreatitis; CRC cis rs7618915 0.547 rs68021750 chr3:52624769 G/A cg07507251 chr3:52567010 NT5DC2 0.42 5.98 0.31 5.82e-9 Bipolar disorder; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg10145211 chr11:64885345 ZNHIT2 0.42 6.07 0.32 3.5e-9 Intelligence (multi-trait analysis); CRC cis rs2762353 0.595 rs1892256 chr6:25754271 C/T cg03517284 chr6:25882590 NA 0.74 10.46 0.5 2.8e-22 Blood metabolite levels; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg15260519 chr4:187113285 CYP4V2 0.44 6.17 0.32 1.99e-9 Response to antipsychotic treatment; CRC cis rs6088590 0.561 rs6088528 chr20:33156742 G/A cg08999081 chr20:33150536 PIGU 0.63 12.4 0.56 3.23e-29 Coronary artery disease; CRC cis rs755249 0.532 rs61779277 chr1:39833535 G/A cg18385671 chr1:39797026 MACF1 -0.4 -5.78 -0.3 1.74e-8 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs7312933 0.618 rs7315968 chr12:42637086 G/A cg11827402 chr12:42719852 PPHLN1;ZCRB1 0.62 8.74 0.43 1.18e-16 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CRC cis rs1707322 1.000 rs785498 chr1:46592414 C/T cg03146154 chr1:46216737 IPP -0.53 -7.23 -0.37 3.34e-12 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs9311474 0.607 rs34005367 chr3:52558904 A/T cg18099408 chr3:52552593 STAB1 -0.52 -9.01 -0.44 1.69e-17 Electroencephalogram traits; CRC trans rs7395662 0.926 rs7122869 chr11:48727999 G/T cg21153622 chr11:89784906 NA 0.46 7.41 0.38 1.06e-12 HDL cholesterol; CRC trans rs7615952 0.741 rs13314845 chr3:125644782 C/T cg02007433 chr3:129722099 NA -0.46 -6.25 -0.33 1.3e-9 Blood pressure (smoking interaction); CRC cis rs1577917 0.655 rs7766485 chr6:86263555 T/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A 0.49 6.94 0.36 2.06e-11 Response to antipsychotic treatment; CRC cis rs9322193 1.000 rs9767077 chr6:150109615 T/A cg07701084 chr6:150067640 NUP43 0.47 6.61 0.34 1.51e-10 Lung cancer; CRC cis rs7772486 0.875 rs9390377 chr6:146386932 G/A cg13319975 chr6:146136371 FBXO30 -0.39 -5.96 -0.31 6.52e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs41271951 0.512 rs41266632 chr1:151042980 C/T cg11822372 chr1:151115635 SEMA6C -0.71 -5.73 -0.3 2.3e-8 Blood protein levels; CRC cis rs2204008 0.728 rs12369538 chr12:38443942 C/T cg26384229 chr12:38710491 ALG10B 0.67 9.15 0.45 6.1e-18 Bladder cancer; CRC cis rs35883536 0.967 rs1855788 chr1:101118331 A/G cg14515779 chr1:101123966 NA -0.42 -8.12 -0.41 9.57e-15 Monocyte count; CRC cis rs10919791 0.501 rs12024418 chr1:199916164 T/C cg07208853 chr1:200005219 NR5A2 0.24 6.04 0.32 4.09e-9 Pancreatic cancer; CRC cis rs13108904 0.870 rs13115355 chr4:1261576 G/A cg16405210 chr4:1374714 KIAA1530 -0.42 -5.89 -0.31 9.42e-9 Obesity-related traits; CRC cis rs7208859 0.573 rs73267865 chr17:29064204 C/G cg13385521 chr17:29058706 SUZ12P 0.72 8.17 0.41 6.77e-15 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs6570726 0.818 rs9399555 chr6:145877554 T/C cg23711669 chr6:146136114 FBXO30 0.68 11.36 0.53 1.95e-25 Lobe attachment (rater-scored or self-reported); CRC cis rs2708977 0.966 rs2708978 chr2:97202243 A/C cg01950434 chr2:97203154 ARID5A -0.49 -7.15 -0.37 5.55e-12 Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes; CRC cis rs13315871 1.000 rs28626602 chr3:58409786 G/C cg20936604 chr3:58311152 NA -0.75 -7.12 -0.37 6.99e-12 Cholesterol, total; CRC cis rs7517126 0.920 rs7552547 chr1:196836999 T/G cg13682187 chr1:196946512 CFHR5 -0.37 -5.98 -0.31 5.67e-9 Blood protein levels; CRC cis rs854765 0.647 rs854769 chr17:18019011 A/G cg24612305 chr17:17875800 TOM1L2;LRRC48 -0.68 -11.11 -0.52 1.43e-24 Total body bone mineral density; CRC trans rs2727020 0.553 rs11040400 chr11:49518296 C/A cg11707556 chr5:10655725 ANKRD33B -0.41 -7.58 -0.39 3.52e-13 Coronary artery disease; CRC cis rs733592 0.524 rs10875744 chr12:48498440 G/C cg21466736 chr12:48725269 NA -0.51 -8.01 -0.4 2.01e-14 Plateletcrit; CRC cis rs11690935 0.959 rs12185567 chr2:172560729 A/C cg13550731 chr2:172543902 DYNC1I2 1.09 19.01 0.72 7e-55 Schizophrenia; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg22691505 chr7:6312217 CYTH3 0.38 6.07 0.32 3.51e-9 Liver disease severity in Alagille syndrome; CRC trans rs61931739 0.500 rs7977194 chr12:34408459 G/A cg26384229 chr12:38710491 ALG10B 0.67 8.91 0.44 3.63e-17 Morning vs. evening chronotype; CRC cis rs801193 1.000 rs6975195 chr7:66124774 T/A cg00343986 chr7:65444356 GUSB -0.49 -7.23 -0.37 3.38e-12 Aortic root size; CRC cis rs524281 1.000 rs527897 chr11:65900777 C/T cg16950941 chr11:66035639 RAB1B -0.6 -8.51 -0.42 6.25e-16 Electroencephalogram traits; CRC cis rs68170813 0.559 rs1548524 chr7:106944563 G/T cg02696742 chr7:106810147 HBP1 0.61 7.13 0.37 6.38e-12 Coronary artery disease; CRC cis rs6951245 0.554 rs75075857 chr7:1140298 C/T cg03188948 chr7:1209495 NA 0.5 5.92 0.31 7.89e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC trans rs2303319 0.504 rs12467662 chr2:162386784 G/A cg18122310 chr12:50236657 BCDIN3D -0.72 -6.04 -0.32 4.15e-9 Cognitive function; CRC trans rs10242455 0.867 rs3735453 chr7:99229435 C/T cg09045935 chr12:6379348 NA -0.55 -6.1 -0.32 3.01e-9 Blood metabolite levels; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg12296218 chr15:48624389 DUT 0.45 6.25 0.33 1.27e-9 Anxiety disorder; CRC cis rs11212617 0.967 rs583725 chr11:108165075 A/G cg14761454 chr11:108092087 ATM;NPAT 0.42 6.16 0.32 2.08e-9 Response to metformin in type 2 diabetes (glycemic); CRC cis rs11148252 0.669 rs4884320 chr13:53006914 T/C cg02158880 chr13:53174818 NA 0.49 6.82 0.35 4.26e-11 Lewy body disease; CRC cis rs6952808 0.723 rs55689856 chr7:2037215 G/A cg22963979 chr7:1858916 MAD1L1 -0.52 -7.76 -0.39 1.08e-13 Bipolar disorder and schizophrenia; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg08165151 chr6:88411075 NCRNA00120;AKIRIN2 0.47 6.52 0.34 2.61e-10 Response to antipsychotic treatment; CRC cis rs12824058 0.831 rs12320318 chr12:130812335 T/C cg24838063 chr12:130822603 PIWIL1 0.58 9.76 0.47 6.18e-20 Menopause (age at onset); CRC cis rs10504229 0.683 rs10504223 chr8:58140944 G/A cg04204079 chr8:58130323 NA -0.45 -5.78 -0.3 1.71e-8 Developmental language disorder (linguistic errors); CRC cis rs780096 0.505 rs12475426 chr2:27599132 G/A cg24768116 chr2:27665128 KRTCAP3 -0.35 -7.95 -0.4 3e-14 Total body bone mineral density; CRC cis rs3931020 0.548 rs17618340 chr1:75247617 G/A cg10128416 chr1:75198403 TYW3;CRYZ 0.5 6.8 0.35 4.92e-11 Resistin levels; CRC cis rs34375054 0.525 rs7133614 chr12:125605957 C/T cg06287003 chr12:125626642 AACS -0.5 -7.44 -0.38 9.1e-13 Post bronchodilator FEV1/FVC ratio; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg19787033 chr11:77850962 ALG8 0.47 6.45 0.34 4e-10 Thyroid stimulating hormone; CRC cis rs9818758 0.607 rs3923475 chr3:49055788 G/T cg07636037 chr3:49044803 WDR6 -0.82 -6.67 -0.35 1.08e-10 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; CRC cis rs12541335 0.639 rs11779277 chr8:22200683 C/T cg26039829 chr8:22132926 PIWIL2 0.52 9.17 0.45 5.33e-18 Hypertriglyceridemia; CRC cis rs6951245 1.000 rs6951245 chr7:1058193 G/A cg24642844 chr7:1081250 C7orf50 -0.75 -8.96 -0.44 2.39e-17 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs2072499 0.966 rs6427307 chr1:156190083 A/G cg24450063 chr1:156163899 SLC25A44 1.14 26.91 0.83 3.96e-85 Testicular germ cell tumor; CRC cis rs826838 0.754 rs2387920 chr12:38626351 A/G cg13010199 chr12:38710504 ALG10B 0.45 5.74 0.3 2.17e-8 Heart rate; CRC cis rs10504229 1.000 rs17805656 chr8:58180318 T/C cg24829409 chr8:58192753 C8orf71 -0.68 -11.34 -0.53 2.27e-25 Developmental language disorder (linguistic errors); CRC trans rs1455244 0.700 rs7229302 chr18:11508904 G/T cg00794927 chr19:17187156 MYO9B;HAUS8 0.4 6.06 0.32 3.66e-9 Schizophrenia; CRC trans rs2303319 0.504 rs12467613 chr2:162603216 G/T cg23919916 chr10:103825097 HPS6 -0.69 -6.01 -0.31 4.8e-9 Cognitive function; CRC cis rs490234 0.627 rs4838276 chr9:128364901 A/G cg14078157 chr9:128172775 NA 0.37 6.16 0.32 2.12e-9 Mean arterial pressure; CRC cis rs3087591 0.922 rs2905801 chr17:29524974 C/T cg24425628 chr17:29625626 OMG;NF1 0.81 14.07 0.61 1.53e-35 Hip circumference; CRC cis rs1395 0.813 rs11685326 chr2:27453679 A/G cg14242246 chr2:27434262 C2orf28;SLC5A6 0.43 7.87 0.4 5.17e-14 Blood metabolite levels; CRC cis rs1062746 0.528 rs11646030 chr16:87339278 T/C cg02258303 chr16:87377426 FBXO31 -0.54 -7.87 -0.4 5.28e-14 Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 2 peripheral neuropathy); CRC cis rs7725052 0.609 rs10941507 chr5:40458916 T/C cg09067459 chr5:40385259 NA -0.4 -6.63 -0.34 1.4e-10 Pediatric autoimmune diseases; CRC cis rs7618915 0.547 rs34017441 chr3:52742413 T/C cg05573699 chr3:52720067 GNL3;PBRM1 -0.49 -6.91 -0.36 2.51e-11 Bipolar disorder; CRC trans rs4276421 0.806 rs34666220 chr5:45435986 T/A cg04793272 chr11:119020941 ABCG4 -0.38 -6.29 -0.33 1.02e-9 P wave duration; CRC cis rs11785400 0.793 rs7459963 chr8:143737129 C/T cg24634471 chr8:143751801 JRK 0.49 6.57 0.34 1.98e-10 Schizophrenia; CRC cis rs56104184 0.775 rs17272700 chr19:49391770 G/A cg21252483 chr19:49399788 TULP2 -0.4 -6.06 -0.32 3.76e-9 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; CRC cis rs3806843 1.000 rs3733710 chr5:140167463 C/T cg19875535 chr5:140030758 IK 0.6 9.79 0.47 5.14e-20 Depressive symptoms (multi-trait analysis); CRC cis rs4862750 0.832 rs6419953 chr4:187900509 T/A cg03452623 chr4:187889614 NA -0.92 -22.45 -0.78 2.37e-68 Lobe attachment (rater-scored or self-reported); CRC cis rs7914558 0.966 rs10786719 chr10:104637992 C/T cg15744005 chr10:104629667 AS3MT 0.33 7.02 0.36 1.31e-11 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs7605827 0.930 rs2111453 chr2:15673248 C/T cg19274914 chr2:15703543 NA 0.39 5.87 0.31 1.07e-8 Educational attainment (years of education); CRC cis rs4604732 0.631 rs34443739 chr1:247626913 A/G cg02104434 chr1:247694406 LOC148824;OR2C3 0.6 8.82 0.44 6.97e-17 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CRC cis rs734999 0.545 rs12749591 chr1:2563250 G/T cg20673091 chr1:2541236 MMEL1 -0.36 -5.73 -0.3 2.25e-8 Ulcerative colitis; CRC cis rs9905704 0.624 rs4932691 chr17:57094617 T/C cg12560992 chr17:57184187 TRIM37 -0.65 -9.92 -0.48 1.8899999999999998e-20 Testicular germ cell tumor; CRC cis rs10911390 0.793 rs12040054 chr1:183639566 C/G cg11505048 chr1:183622726 RGL1;APOBEC4 0.81 7.06 0.36 1.01e-11 Systemic lupus erythematosus; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg27138088 chr11:842605 TSPAN4;POLR2L -0.42 -6.51 -0.34 2.86e-10 Myopia (pathological); CRC cis rs28386778 0.897 rs2584639 chr17:61863732 C/T cg25654072 chr17:61904446 PSMC5;FTSJ3 0.72 11.3 0.53 2.97e-25 Prudent dietary pattern; CRC cis rs34638657 0.518 rs7196560 chr16:82168162 A/T cg07918374 chr16:82182319 MPHOSPH6 0.44 6.32 0.33 8.45e-10 Lung adenocarcinoma; CRC cis rs8038465 0.615 rs6495076 chr15:73982965 G/A cg15420318 chr15:73925796 NPTN 0.37 5.66 0.3 3.24e-8 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs1862618 0.671 rs2034244 chr5:56242774 T/C cg03609598 chr5:56110824 MAP3K1 0.59 8.1 0.41 1.09e-14 Initial pursuit acceleration; CRC trans rs11026407 0.967 rs7127246 chr11:22060228 C/G cg27049318 chr5:68514098 MRPS36 -0.59 -6.04 -0.32 4.07e-9 Plasma thyroid-stimulating hormone levels; CRC cis rs7291412 0.540 rs9627391 chr22:46447097 C/T cg05468064 chr22:46423449 NA 0.33 5.85 0.31 1.19e-8 Dupuytren's disease;Subjective well-being; CRC cis rs11098499 0.863 rs3736115 chr4:120488703 A/G cg24375607 chr4:120327624 NA -0.48 -7.27 -0.37 2.61e-12 Corneal astigmatism; CRC cis rs863345 0.604 rs1342954 chr1:158464548 C/A cg12129480 chr1:158549410 OR10X1 -0.3 -6.35 -0.33 7.19e-10 Pneumococcal bacteremia; CRC cis rs67311347 0.955 rs6782746 chr3:40510592 A/G cg24209194 chr3:40518798 ZNF619 -0.42 -6.09 -0.32 3.17e-9 Renal cell carcinoma; CRC cis rs9341808 0.600 rs2505930 chr6:80837058 A/G cg08355045 chr6:80787529 NA 0.38 6.11 0.32 2.86e-9 Sitting height ratio; CRC cis rs7618915 0.532 rs13060675 chr3:52674300 T/G cg18099408 chr3:52552593 STAB1 -0.43 -7.08 -0.36 8.86e-12 Bipolar disorder; CRC cis rs523522 0.962 rs509445 chr12:121017243 A/C cg27279351 chr12:120934652 DYNLL1 0.75 10.75 0.51 2.64e-23 High light scatter reticulocyte count; CRC cis rs780096 0.506 rs56076827 chr2:27676287 A/T cg27432699 chr2:27873401 GPN1 -0.62 -9.48 -0.46 5.39e-19 Total body bone mineral density; CRC cis rs7493 0.755 rs116306774 chr7:95016976 G/A cg20119798 chr7:94954144 PON1 -0.47 -5.88 -0.31 9.89e-9 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs2019137 0.560 rs4849179 chr2:113985170 C/T cg21550016 chr2:113992930 PAX8;LOC440839;LOC654433 0.65 10.11 0.49 4.26e-21 Lymphocyte counts; CRC cis rs2404602 0.709 rs11072597 chr15:76763514 C/A cg23625390 chr15:77176239 SCAPER -0.84 -12.73 -0.57 1.79e-30 Blood metabolite levels; CRC cis rs11105298 0.891 rs11105309 chr12:89909850 T/C cg08166232 chr12:89918718 WDR51B;GALNT4 -0.61 -7.74 -0.39 1.24e-13 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; CRC cis rs10504229 0.683 rs11774645 chr8:58132921 G/C cg11062466 chr8:58055876 NA 0.54 6.82 0.35 4.35e-11 Developmental language disorder (linguistic errors); CRC cis rs7552404 0.731 rs11161836 chr1:76354333 C/T cg10523679 chr1:76189770 ACADM 0.74 8.73 0.43 1.32e-16 Blood metabolite levels;Acylcarnitine levels; CRC cis rs4713118 0.869 rs9461401 chr6:27703291 G/A cg21251018 chr6:28226885 NKAPL 0.38 5.71 0.3 2.5e-8 Parkinson's disease; CRC cis rs6752107 1.000 rs6708373 chr2:234172846 A/G cg07618928 chr2:234183455 ATG16L1;SCARNA5 0.66 11.42 0.53 1.14e-25 Crohn's disease;Inflammatory bowel disease; CRC cis rs12926788 0.640 rs73551577 chr16:24845143 G/A cg06505273 chr16:24850292 NA 0.52 6.76 0.35 6.45e-11 Ejection fraction in Tripanosoma cruzi seropositivity; CRC cis rs9467711 0.659 rs35433030 chr6:26529890 G/A cg16898833 chr6:26189333 HIST1H4D 1.14 8.46 0.42 8.89e-16 Autism spectrum disorder or schizophrenia; CRC cis rs8114671 0.562 rs1801310 chr20:33517014 A/G cg07148914 chr20:33460835 GGT7 0.46 7.33 0.37 1.85e-12 Height; CRC trans rs1945213 0.694 rs17149976 chr11:55839746 T/C cg15704280 chr7:45808275 SEPT13 0.55 6.15 0.32 2.25e-9 Acute lymphoblastic leukemia (childhood); CRC cis rs2882667 0.690 rs274117 chr5:138065048 A/G cg09476006 chr5:138032270 NA 0.58 10.42 0.5 3.74e-22 Age-related hearing impairment (SNP x SNP interaction); CRC trans rs2243480 1.000 rs6966322 chr7:65646754 A/G cg10756647 chr7:56101905 PSPH -0.76 -7.87 -0.4 5.31e-14 Diabetic kidney disease; CRC cis rs3768617 0.510 rs6424889 chr1:183091796 G/C ch.1.3577855R chr1:183094577 LAMC1 0.89 15.86 0.66 1.84e-42 Fuchs's corneal dystrophy; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg04923576 chr1:39956807 BMP8A 0.37 6.15 0.32 2.24e-9 Liver disease severity in Alagille syndrome; CRC cis rs317689 0.819 rs317664 chr12:69704747 C/A cg20891283 chr12:69753455 YEATS4 0.47 6.07 0.32 3.48e-9 Response to diuretic therapy; CRC cis rs873946 0.648 rs1543593 chr10:134553185 A/T cg18305652 chr10:134549665 INPP5A 0.5 6.54 0.34 2.38e-10 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CRC cis rs7246657 0.943 rs7252099 chr19:37933780 G/A cg23950597 chr19:37808831 NA -0.54 -6.51 -0.34 2.82e-10 Coronary artery calcification; CRC cis rs490234 0.702 rs35129945 chr9:128320134 C/T cg14078157 chr9:128172775 NA -0.38 -6.36 -0.33 6.87e-10 Mean arterial pressure; CRC cis rs9611565 0.659 rs169361 chr22:41877989 A/G cg03806693 chr22:41940476 POLR3H 1.05 13.41 0.59 5.39e-33 Vitiligo; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg08721347 chr1:95538652 ALG14 0.53 6.89 0.36 2.85e-11 Thyroid stimulating hormone; CRC cis rs2404602 0.647 rs11072616 chr15:76985269 T/C cg03037974 chr15:76606532 NA -0.52 -7.92 -0.4 3.64e-14 Blood metabolite levels; CRC cis rs4141404 0.787 rs11913992 chr22:31585220 G/A cg22777020 chr22:31556080 RNF185 -0.45 -5.86 -0.31 1.14e-8 Paclitaxel-induced neuropathy; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg09775628 chr19:1479573 C19orf25 0.42 6.85 0.35 3.65e-11 Liver disease severity in Alagille syndrome; CRC cis rs9875589 0.509 rs11927267 chr3:14073992 T/G cg14375111 chr3:14165186 TMEM43;CHCHD4 0.42 6.48 0.34 3.34e-10 Ovarian reserve; CRC cis rs9309473 0.948 rs10199224 chr2:73761446 C/G cg20560298 chr2:73613845 ALMS1 -0.49 -5.96 -0.31 6.58e-9 Metabolite levels; CRC cis rs4700695 0.698 rs416369 chr5:65231058 C/T cg21114390 chr5:65439923 SFRS12 0.5 6.18 0.32 1.95e-9 Facial morphology (factor 19); CRC cis rs231513 0.813 rs231495 chr17:41976748 G/C cg26893861 chr17:41843967 DUSP3 -0.63 -6.36 -0.33 6.63e-10 Cognitive function; CRC cis rs6834538 0.520 rs7662311 chr4:113420584 G/T cg10021238 chr4:113569128 MIR367;LARP7 -0.37 -5.8 -0.3 1.55e-8 Free thyroxine concentration; CRC trans rs916888 0.687 rs199456 chr17:44797919 C/T cg22433210 chr17:43662623 NA 0.98 10.17 0.49 2.64e-21 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs6714710 0.603 rs34974566 chr2:98552299 C/G cg26665480 chr2:98280029 ACTR1B 0.55 7.53 0.38 4.97e-13 Posterior cortical atrophy and Alzheimer's disease; CRC cis rs7726839 0.540 rs72705102 chr5:659437 T/C cg16447950 chr5:562315 NA -0.77 -10.08 -0.49 5.3e-21 Obesity-related traits; CRC cis rs524281 0.861 rs10791854 chr11:65963543 A/T cg14036092 chr11:66035641 RAB1B -0.47 -5.74 -0.3 2.1e-8 Electroencephalogram traits; CRC cis rs9611565 0.918 rs9611562 chr22:41760172 T/G cg03806693 chr22:41940476 POLR3H -1.03 -13.2 -0.59 3.23e-32 Vitiligo; CRC cis rs7224685 0.501 rs7211478 chr17:3897178 C/T cg05562828 chr17:3906858 NA 0.73 13.97 0.61 3.88e-35 Type 2 diabetes; CRC cis rs9491140 0.539 rs980657 chr6:124690330 C/T cg05308643 chr6:124982296 NKAIN2 0.47 6.57 0.34 1.98e-10 Neuroticism; CRC cis rs4731207 0.596 rs10954062 chr7:124636460 T/C cg23710748 chr7:124431027 NA -0.39 -6.26 -0.33 1.17e-9 Cutaneous malignant melanoma; CRC trans rs1578862 0.901 rs2211273 chr1:247433959 A/G cg06850283 chr5:44389769 FGF10 0.25 5.98 0.31 5.73e-9 Monocyte percentage of white cells; CRC cis rs6963495 0.872 rs1569134 chr7:105158228 T/C cg02135003 chr7:105160482 PUS7 -0.9 -12.2 -0.56 1.71e-28 Bipolar disorder (body mass index interaction); CRC cis rs12476592 0.602 rs989527 chr2:63726791 G/T cg10828910 chr2:63850056 LOC388955 0.49 6.08 0.32 3.33e-9 Childhood ear infection; CRC cis rs972578 0.747 rs5758977 chr22:43236128 A/G cg01576275 chr22:43409880 NA -0.39 -6.08 -0.32 3.33e-9 Mean platelet volume; CRC cis rs8062405 1.000 rs3088215 chr16:28853996 A/C cg08761264 chr16:28874980 SH2B1 -0.44 -5.84 -0.31 1.28e-8 Cognitive ability (multi-trait analysis);Cognitive ability; CRC cis rs2032447 0.670 rs198848 chr6:26106325 A/G cg03517284 chr6:25882590 NA -0.41 -5.68 -0.3 2.93e-8 Intelligence (multi-trait analysis); CRC cis rs12580194 1.000 rs73118926 chr12:55703335 A/G cg19537932 chr12:55886519 OR6C68 -0.55 -6.37 -0.33 6.35e-10 Cancer; CRC cis rs11212617 0.875 rs228597 chr11:108107009 G/A cg01991180 chr11:108092276 ATM;NPAT 0.43 6.34 0.33 7.7e-10 Response to metformin in type 2 diabetes (glycemic); CRC cis rs7618915 0.501 rs13079063 chr3:52744460 A/G cg10802521 chr3:52805072 NEK4 -0.58 -9.05 -0.45 1.32e-17 Bipolar disorder; CRC cis rs2991971 0.967 rs7526665 chr1:46005832 G/T cg24296786 chr1:45957014 TESK2 0.52 7.75 0.39 1.14e-13 High light scatter reticulocyte count; CRC cis rs10193935 0.901 rs222463 chr2:42644080 A/G cg27598129 chr2:42591480 NA -0.64 -7.51 -0.38 5.44e-13 Colonoscopy-negative controls vs population controls; CRC cis rs7412746 0.634 rs72704658 chr1:150833010 T/C cg17724175 chr1:150552817 MCL1 0.51 7.5 0.38 6.07e-13 Melanoma; CRC trans rs2303319 0.504 rs62187571 chr2:162374319 A/G cg27113153 chr11:123612418 ZNF202 -0.72 -6.17 -0.32 1.96e-9 Cognitive function; CRC cis rs9393692 0.905 rs9358919 chr6:26287862 C/T cg13736514 chr6:26305472 NA -0.6 -11.27 -0.53 3.97e-25 Educational attainment; CRC cis rs763121 0.962 rs138703 chr22:39132748 C/T cg06544989 chr22:39130855 UNC84B 0.48 7.53 0.38 4.88e-13 Menopause (age at onset); CRC cis rs7811142 1.000 rs7783159 chr7:100017454 C/T cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.99 12.93 0.58 3.33e-31 Platelet count; CRC cis rs6495122 0.618 rs4886413 chr15:75262310 G/C cg17294928 chr15:75287854 SCAMP5 0.49 7.1 0.36 7.66e-12 Caffeine consumption;Diastolic blood pressure;Coffee consumption; CRC cis rs11122272 0.735 rs2491407 chr1:231518928 G/A cg06096015 chr1:231504339 EGLN1 0.4 5.94 0.31 7.17e-9 Hemoglobin concentration; CRC cis rs11229555 0.645 rs12794534 chr11:58179568 C/A cg15696309 chr11:58395628 NA -0.81 -10.31 -0.49 8.83e-22 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; CRC cis rs870825 0.655 rs10013685 chr4:185617785 C/T cg04058563 chr4:185651563 MLF1IP 0.72 9.36 0.46 1.32e-18 Blood protein levels; CRC trans rs66573146 1.000 rs28729690 chr4:6962061 C/T cg07817883 chr1:32538562 TMEM39B 1.38 12.69 0.57 2.63e-30 Granulocyte percentage of myeloid white cells; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg17861791 chr1:113162073 ST7L;CAPZA1 0.43 6.3 0.33 9.41e-10 Intelligence (multi-trait analysis); CRC cis rs2721195 0.654 rs4610795 chr8:145881333 C/T cg17328964 chr8:145687451 CYHR1 0.45 7.29 0.37 2.33e-12 Age at first birth; CRC cis rs9322193 0.962 rs62441335 chr6:150113794 G/A cg05861140 chr6:150128134 PCMT1 -0.43 -7.05 -0.36 1.03e-11 Lung cancer; CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg18052984 chr12:51158439 ATF1 0.38 6.01 0.31 4.84e-9 Obesity-related traits; CRC cis rs1975974 0.872 rs17052344 chr17:21717543 A/G cg18423549 chr17:21743878 NA 0.63 8.94 0.44 2.78e-17 Psoriasis; CRC cis rs427941 0.632 rs201469 chr7:101743932 C/G cg06246474 chr7:101738831 CUX1 0.43 6.68 0.35 1.01e-10 Plasma omega-3 polyunsaturated fatty acid level (eicosapentaenoic acid); CRC cis rs763121 0.853 rs5757253 chr22:39104320 C/T cg06022373 chr22:39101656 GTPBP1 0.82 13.59 0.6 1.09e-33 Menopause (age at onset); CRC cis rs7927771 0.832 rs4752994 chr11:47411065 A/T cg20307385 chr11:47447363 PSMC3 0.65 9.47 0.46 5.59e-19 Subjective well-being; CRC cis rs938554 0.826 rs7376960 chr4:9970570 A/G cg00071950 chr4:10020882 SLC2A9 -0.45 -6.02 -0.31 4.72e-9 Blood metabolite levels; CRC cis rs1023500 0.573 rs133374 chr22:42465941 G/A cg25452165 chr22:42524984 CYP2D6 0.39 5.92 0.31 7.9e-9 Schizophrenia; CRC cis rs17854409 0.881 rs68091818 chr20:61479882 A/C cg05147244 chr20:61493195 TCFL5 0.58 5.84 0.31 1.29e-8 Obesity-related traits; CRC cis rs34779708 0.733 rs11597184 chr10:35397396 G/A cg03585969 chr10:35415529 CREM 0.66 8.78 0.44 9.08e-17 Inflammatory bowel disease;Crohn's disease; CRC cis rs11122272 0.766 rs1435166 chr1:231502310 T/C cg06096015 chr1:231504339 EGLN1 0.39 6.0 0.31 5.17e-9 Hemoglobin concentration; CRC cis rs9905704 0.836 rs12952429 chr17:56843070 C/T cg12560992 chr17:57184187 TRIM37 0.54 7.81 0.4 7.49e-14 Testicular germ cell tumor; CRC cis rs6860806 0.661 rs2171247 chr5:131580234 G/T cg22638593 chr5:131593259 PDLIM4 0.38 6.99 0.36 1.58e-11 Breast cancer; CRC cis rs8141529 0.748 rs6519766 chr22:29269991 A/G cg15103426 chr22:29168792 CCDC117 -0.51 -7.04 -0.36 1.09e-11 Lymphocyte counts; CRC cis rs1401999 0.966 rs4148585 chr3:183670642 A/G cg20387954 chr3:183756860 HTR3D 0.46 7.74 0.39 1.26e-13 Anterior chamber depth; CRC cis rs870825 0.616 rs7678900 chr4:185635249 A/G cg04058563 chr4:185651563 MLF1IP 0.72 9.44 0.46 7.24e-19 Blood protein levels; CRC cis rs12586317 0.576 rs6571696 chr14:35630175 A/G cg07166546 chr14:35805898 NA -0.3 -5.88 -0.31 9.97e-9 Psoriasis; CRC cis rs2404602 0.583 rs12913096 chr15:76551852 C/T cg03037974 chr15:76606532 NA 0.84 17.06 0.69 3.43e-47 Blood metabolite levels; CRC cis rs847577 0.677 rs1495525 chr7:97826232 G/A cg24562669 chr7:97807699 LMTK2 -0.64 -12.0 -0.55 9.15e-28 Breast cancer; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg22435982 chr17:42441259 FAM171A2 0.45 6.11 0.32 2.74e-9 Anxiety disorder; CRC trans rs916888 0.821 rs199512 chr17:44857352 T/C cg22968622 chr17:43663579 NA -1.2 -15.72 -0.65 6.5e-42 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs12325245 0.536 rs12925676 chr16:58625326 C/T cg19824325 chr16:58548873 SETD6 1.0 6.84 0.35 3.87e-11 Schizophrenia; CRC cis rs10504229 0.724 rs72650827 chr8:58126884 A/T cg02725872 chr8:58115012 NA -0.64 -11.55 -0.54 3.85e-26 Developmental language disorder (linguistic errors); CRC cis rs6674176 0.561 rs12127226 chr1:44395309 C/T cg15962314 chr1:44399869 ARTN 0.31 6.03 0.32 4.31e-9 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Cognitive ability; CRC cis rs4713118 0.662 rs149900 chr6:28014597 C/T cg21251018 chr6:28226885 NKAPL 0.46 6.56 0.34 2.04e-10 Parkinson's disease; CRC cis rs2153535 0.580 rs9406165 chr6:8488837 C/T cg07606381 chr6:8435919 SLC35B3 0.66 10.65 0.51 5.96e-23 Motion sickness; CRC cis rs1165205 0.558 rs531750 chr6:25882642 C/G cg07061783 chr6:25882402 NA -0.48 -6.39 -0.33 5.8e-10 Urate levels; CRC cis rs7914558 0.966 rs7921574 chr10:104840970 T/C cg04362960 chr10:104952993 NT5C2 0.59 8.82 0.44 6.6e-17 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs2032447 0.670 rs198815 chr6:26127271 A/G cg12310025 chr6:25882481 NA 0.46 6.26 0.33 1.23e-9 Intelligence (multi-trait analysis); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg00006884 chr7:23637030 CCDC126 0.46 6.39 0.33 5.51e-10 Response to antipsychotic treatment; CRC cis rs34779708 0.931 rs72789609 chr10:35306206 C/T cg03585969 chr10:35415529 CREM 0.65 8.64 0.43 2.46e-16 Inflammatory bowel disease;Crohn's disease; CRC cis rs17152411 1.000 rs17152411 chr10:126649516 A/G cg07906193 chr10:126599966 NA 0.61 7.01 0.36 1.34e-11 Height; CRC cis rs6951245 1.000 rs74347384 chr7:1072440 G/A cg21664854 chr7:1097933 C7orf50;GPR146 0.79 8.92 0.44 3.39e-17 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg10955293 chr1:24117561 LYPLA2 0.42 6.55 0.34 2.18e-10 Intelligence (multi-trait analysis); CRC cis rs9467711 0.790 rs1979 chr6:26377591 G/T cg16898833 chr6:26189333 HIST1H4D 0.77 6.47 0.34 3.51e-10 Autism spectrum disorder or schizophrenia; CRC cis rs9303280 0.806 rs11078928 chr17:38064469 T/C cg17344932 chr17:38183730 MED24;SNORD124 0.39 6.16 0.32 2.14e-9 Self-reported allergy; CRC cis rs7119 0.689 rs12907630 chr15:77812906 G/T cg27398640 chr15:77910606 LINGO1 -0.45 -8.08 -0.41 1.22e-14 Type 2 diabetes; CRC cis rs9467711 0.591 rs6903228 chr6:25903047 A/G cg16898833 chr6:26189333 HIST1H4D 0.63 5.78 0.3 1.77e-8 Autism spectrum disorder or schizophrenia; CRC cis rs950169 0.545 rs4842841 chr15:84641125 G/A cg11189052 chr15:85197271 WDR73 0.55 7.22 0.37 3.64e-12 Schizophrenia; CRC cis rs7605827 0.930 rs1997305 chr2:15512383 T/C cg19274914 chr2:15703543 NA 0.39 6.03 0.32 4.36e-9 Educational attainment (years of education); CRC cis rs2749592 0.918 rs11011388 chr10:38155210 C/T cg00409905 chr10:38381863 ZNF37A 0.49 6.79 0.35 5.13e-11 Age-related hearing impairment (SNP x SNP interaction); CRC trans rs9291683 0.575 rs3756223 chr4:10105797 C/T cg26043149 chr18:55253948 FECH 0.46 6.94 0.36 2.13e-11 Bone mineral density; CRC cis rs4713118 0.955 rs9380012 chr6:27684654 A/G cg02683197 chr6:28174875 NA 0.57 7.53 0.38 5.05e-13 Parkinson's disease; CRC cis rs9359856 0.510 rs6937244 chr6:90468465 C/A cg13799429 chr6:90582589 CASP8AP2 0.77 10.14 0.49 3.42e-21 Bipolar disorder; CRC cis rs6920364 1 rs6920364 chr6:167376466 G/C cg23791538 chr6:167370224 RNASET2 0.38 5.87 0.31 1.04e-8 Lung cancer; CRC cis rs7552404 0.731 rs5745458 chr1:76345429 G/A cg22875332 chr1:76189707 ACADM -0.59 -7.38 -0.38 1.3e-12 Blood metabolite levels;Acylcarnitine levels; CRC cis rs9527 0.544 rs1572578 chr10:104822431 C/G cg15744005 chr10:104629667 AS3MT -0.3 -5.96 -0.31 6.54e-9 Arsenic metabolism; CRC cis rs7412746 0.611 rs111905669 chr1:150777565 T/C cg10589385 chr1:150898437 SETDB1 0.28 5.81 0.31 1.47e-8 Melanoma; CRC trans rs9329221 0.736 rs2001338 chr8:10251217 A/G cg06636001 chr8:8085503 FLJ10661 0.51 7.59 0.39 3.41e-13 Neuroticism; CRC cis rs798554 0.679 rs798499 chr7:2792013 G/A cg13628971 chr7:2884303 GNA12 0.45 6.99 0.36 1.52e-11 Height; CRC cis rs208515 0.525 rs12204452 chr6:66680325 C/T cg07460842 chr6:66804631 NA 0.95 12.02 0.55 7.47e-28 Exhaled nitric oxide levels; CRC cis rs6860806 0.661 rs2136187 chr5:131577894 T/C cg09877947 chr5:131593287 PDLIM4 0.47 8.93 0.44 2.97e-17 Breast cancer; CRC cis rs1832871 0.711 rs9459826 chr6:158680396 C/G cg07165851 chr6:158734300 TULP4 -0.63 -7.93 -0.4 3.39e-14 Height; CRC trans rs2727020 0.704 rs2988340 chr11:49176057 C/T cg21153622 chr11:89784906 NA -0.43 -6.88 -0.35 3.09e-11 Coronary artery disease; CRC trans rs2727020 0.538 rs61885230 chr11:49128958 T/C cg21153622 chr11:89784906 NA -0.55 -9.28 -0.46 2.32e-18 Coronary artery disease; CRC cis rs10911232 0.507 rs10797820 chr1:183011366 G/A ch.1.3577855R chr1:183094577 LAMC1 0.83 14.57 0.63 1.8e-37 Hypertriglyceridemia; CRC cis rs6460942 0.908 rs6978768 chr7:12232366 G/A cg06484146 chr7:12443880 VWDE -0.58 -6.01 -0.31 4.8e-9 Coronary artery disease; CRC cis rs561341 0.943 rs508566 chr17:30289861 G/C cg23018236 chr17:30244563 NA -0.65 -7.69 -0.39 1.73e-13 Hip circumference adjusted for BMI; CRC trans rs1814175 0.669 rs11040455 chr11:49669829 G/C cg11707556 chr5:10655725 ANKRD33B -0.36 -6.75 -0.35 6.53e-11 Height; CRC cis rs9916302 0.904 rs11867312 chr17:37597748 C/T cg15445000 chr17:37608096 MED1 0.44 9.68 0.47 1.12e-19 Glomerular filtration rate (creatinine); CRC cis rs6762 0.748 rs1130719 chr11:838760 T/A cg03885332 chr11:832357 CD151 -0.42 -6.21 -0.32 1.59e-9 Mean platelet volume; CRC cis rs10504229 0.683 rs11774697 chr8:58133119 G/A cg02290350 chr8:58132656 NA -0.61 -7.33 -0.37 1.81e-12 Developmental language disorder (linguistic errors); CRC cis rs826838 1.000 rs11183214 chr12:38692938 C/T cg13010199 chr12:38710504 ALG10B 0.49 6.41 0.33 5.11e-10 Heart rate; CRC cis rs2949837 0.581 rs2960437 chr7:45977352 G/A cg06713098 chr7:45960367 IGFBP3 0.42 6.66 0.34 1.13e-10 Sitting height ratio; CRC cis rs59918340 0.764 rs4961338 chr8:142230192 C/T cg17298326 chr8:142245477 NA 0.37 5.65 0.3 3.49e-8 Immature fraction of reticulocytes; CRC cis rs7677751 0.806 rs1800812 chr4:55094629 G/T cg13615338 chr4:55094005 PDGFRA 0.4 5.8 0.3 1.57e-8 Corneal astigmatism; CRC cis rs9807989 0.507 rs10203558 chr2:103027640 T/C cg03938978 chr2:103052716 IL18RAP 0.59 10.13 0.49 3.5e-21 Asthma; CRC cis rs6723226 0.961 rs13010404 chr2:32848854 T/G cg02381751 chr2:32503542 YIPF4 -0.5 -7.12 -0.37 6.65e-12 Intelligence (multi-trait analysis); CRC cis rs4819052 0.765 rs2838854 chr21:46680364 A/G cg11663144 chr21:46675770 NA -0.86 -15.06 -0.64 2.34e-39 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs17155006 0.655 rs430995 chr7:107727501 G/T cg05962710 chr7:107745446 LAMB4 -0.34 -5.74 -0.3 2.13e-8 Pneumococcal bacteremia; CRC cis rs7772486 0.754 rs9386132 chr6:146140751 T/C cg13319975 chr6:146136371 FBXO30 -0.48 -7.15 -0.37 5.65e-12 Lobe attachment (rater-scored or self-reported); CRC cis rs853679 0.517 rs9357066 chr6:28129831 T/C cg12172441 chr6:28176163 NA 0.64 7.53 0.38 5.03e-13 Depression; CRC cis rs155076 0.711 rs4770129 chr13:21882059 T/G cg06138931 chr13:21896616 NA 0.56 7.14 0.37 6.03e-12 White matter hyperintensity burden; CRC cis rs270601 0.913 rs273899 chr5:131695178 G/A cg18758796 chr5:131593413 PDLIM4 0.4 6.46 0.34 3.83e-10 Acylcarnitine levels; CRC trans rs208515 0.556 rs10455193 chr6:66691456 G/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.95 12.11 0.56 3.56e-28 Exhaled nitric oxide levels; CRC cis rs2075371 0.501 rs1421469 chr7:134028260 C/G cg11752832 chr7:134001865 SLC35B4 0.38 5.63 0.3 3.85e-8 Mean platelet volume; CRC cis rs1403694 0.734 rs266723 chr3:186447047 A/C cg04611788 chr3:186434169 KNG1 -0.45 -6.66 -0.34 1.14e-10 Blood protein levels; CRC cis rs6570726 0.846 rs9399559 chr6:145945778 C/T cg23711669 chr6:146136114 FBXO30 0.64 10.62 0.51 7.3e-23 Lobe attachment (rater-scored or self-reported); CRC cis rs7216064 1.000 rs8072225 chr17:65912960 A/G cg12091567 chr17:66097778 LOC651250 -0.63 -7.95 -0.4 2.95e-14 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CRC cis rs12612619 0.732 rs1866654 chr2:27263122 A/G cg00617064 chr2:27272375 NA -0.42 -7.03 -0.36 1.22e-11 Venous thromboembolism adjusted for sickle cell variant rs77121243-T; CRC cis rs9322193 0.923 rs11155674 chr6:150032247 T/C cg07701084 chr6:150067640 NUP43 0.56 8.2 0.41 5.45e-15 Lung cancer; CRC cis rs6714710 0.580 rs17489915 chr2:98420431 T/C cg26665480 chr2:98280029 ACTR1B 0.52 7.18 0.37 4.53e-12 Posterior cortical atrophy and Alzheimer's disease; CRC cis rs59918340 0.728 rs59172574 chr8:142231945 C/G cg03316587 chr8:142245164 NA -0.4 -6.04 -0.32 4.16e-9 Immature fraction of reticulocytes; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg05513509 chr18:20513742 RBBP8 -0.44 -6.56 -0.34 2.06e-10 Myopia (pathological); CRC trans rs475616 0.917 rs866919 chr10:30513283 C/T cg08354699 chr15:63796895 USP3 0.43 6.29 0.33 1.03e-9 Monocyte count; CRC cis rs62064224 0.597 rs7207268 chr17:30725155 T/G cg25809561 chr17:30822961 MYO1D 0.51 9.18 0.45 5.03e-18 Schizophrenia; CRC cis rs7799006 0.593 rs12531150 chr7:2289888 C/T cg08027265 chr7:2291960 NA -0.45 -7.47 -0.38 7.11e-13 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs9894429 0.646 rs7406828 chr17:79619226 A/G cg09655341 chr17:79618100 PDE6G 0.36 6.11 0.32 2.89e-9 Eye color traits; CRC cis rs9435341 0.762 rs2878349 chr1:107549245 G/A cg14671364 chr1:107599128 PRMT6 0.45 5.99 0.31 5.5e-9 Facial morphology (factor 21, depth of nasal alae); CRC cis rs10504229 0.679 rs16921623 chr8:58039473 G/C cg22535103 chr8:58192502 C8orf71 -0.44 -5.77 -0.3 1.85e-8 Developmental language disorder (linguistic errors); CRC cis rs2559856 1.000 rs2695292 chr12:102087290 G/A cg12924262 chr12:102091054 CHPT1 0.55 8.26 0.41 3.58e-15 Blood protein levels; CRC cis rs7591163 0.883 rs16824023 chr2:228720877 G/A cg22079747 chr2:228736145 WDR69 -0.4 -5.72 -0.3 2.34e-8 Blood pressure; CRC cis rs67981189 0.529 rs2810096 chr14:71435300 A/G cg15910301 chr14:71632612 NA -0.28 -5.67 -0.3 3.18e-8 Schizophrenia; CRC cis rs55882075 1.000 rs55882075 chr5:179210115 C/G cg14593053 chr5:179126677 CANX 0.49 7.8 0.4 8.16e-14 Monocyte percentage of white cells; CRC trans rs11098499 0.739 rs9996382 chr4:120151012 C/T cg25214090 chr10:38739885 LOC399744 0.42 6.67 0.35 1.06e-10 Corneal astigmatism; CRC cis rs11997175 0.935 rs6990082 chr8:33708034 C/A ch.8.33884649F chr8:33765107 NA 0.41 6.02 0.31 4.73e-9 Body mass index; CRC cis rs2075371 0.933 rs2544191 chr7:133954248 A/G cg02659138 chr7:134003124 SLC35B4 0.36 6.24 0.33 1.33e-9 Mean platelet volume; CRC cis rs1348850 0.958 rs1545364 chr2:178462882 G/T cg22681709 chr2:178499509 PDE11A -0.32 -5.78 -0.3 1.75e-8 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs796364 0.806 rs11688194 chr2:200916239 C/T cg25936922 chr2:200820526 C2orf60;C2orf47 -0.7 -6.57 -0.34 2.02e-10 Schizophrenia; CRC cis rs713587 0.563 rs2033655 chr2:25101092 C/T cg04586622 chr2:25135609 ADCY3 -0.56 -10.38 -0.5 4.92e-22 Body mass index in non-asthmatics; CRC cis rs1322512 0.760 rs2038615 chr6:152927267 C/T cg03415253 chr6:152958462 SYNE1 0.4 6.11 0.32 2.76e-9 Tonometry; CRC cis rs3790645 1.000 rs188158 chr1:26898142 A/G cg23229016 chr1:26872525 RPS6KA1 0.25 5.96 0.31 6.66e-9 Glucose homeostasis traits; CRC cis rs12550646 0.585 rs74887565 chr8:41681935 T/C cg12180191 chr8:41686706 ANK1 -0.44 -6.29 -0.33 1.01e-9 Reticulocyte fraction of red cells;Reticulocyte count; CRC cis rs10464366 0.544 rs4540324 chr7:39185299 G/C cg21665744 chr7:39171113 POU6F2 0.44 5.9 0.31 9.26e-9 IgG glycosylation; CRC cis rs3806843 0.932 rs2563256 chr5:140141779 G/T cg16607685 chr5:140181889 PCDHA2;PCDHA1;PCDHA3 0.26 5.99 0.31 5.59e-9 Depressive symptoms (multi-trait analysis); CRC cis rs516243 0.841 rs6540944 chr1:10740405 C/T cg02903756 chr1:10750680 CASZ1 -0.5 -8.76 -0.44 1.02e-16 Migraine - clinic-based; CRC cis rs13191362 0.573 rs9365499 chr6:163271833 C/T cg06582575 chr6:163149167 PACRG;PARK2 0.55 7.8 0.39 8.41e-14 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs2153535 0.601 rs9505472 chr6:8538765 T/C cg07606381 chr6:8435919 SLC35B3 0.69 11.24 0.53 5.16e-25 Motion sickness; CRC cis rs477895 0.653 rs66648159 chr11:63899429 G/A cg04317338 chr11:64019027 PLCB3 0.6 7.28 0.37 2.53e-12 Mean platelet volume; CRC trans rs875971 0.660 rs2191268 chr7:66110224 C/T cg25794979 chr16:2732314 KCTD5 -0.38 -5.97 -0.31 6.05e-9 Aortic root size; CRC cis rs847577 0.674 rs7790479 chr7:97713101 C/G cg00277769 chr7:97922759 BAIAP2L1 -0.42 -7.04 -0.36 1.1e-11 Breast cancer; CRC cis rs2882667 0.556 rs6873733 chr5:138403317 G/T cg09476006 chr5:138032270 NA 0.36 6.0 0.31 5.24e-9 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs9660992 0.762 rs1172130 chr1:205244953 G/A cg21643547 chr1:205240462 TMCC2 -0.47 -7.8 -0.4 8.33e-14 Mean corpuscular volume;Mean platelet volume; CRC cis rs597539 0.731 rs664229 chr11:68624483 C/G cg04772025 chr11:68637568 NA 0.52 8.02 0.4 1.88e-14 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg01173912 chr12:1771358 NA 0.47 6.49 0.34 3.23e-10 Response to antipsychotic treatment; CRC cis rs1153858 1.000 rs4775895 chr15:45617957 T/A cg21132104 chr15:45694354 SPATA5L1 0.59 8.28 0.42 3.08e-15 Homoarginine levels; CRC cis rs7811142 0.830 rs41280971 chr7:99954457 G/T cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.73 10.04 0.48 7.2e-21 Platelet count; CRC trans rs61931739 0.534 rs10844732 chr12:34037104 A/C cg26384229 chr12:38710491 ALG10B 0.53 6.76 0.35 6.43e-11 Morning vs. evening chronotype; CRC cis rs898097 0.805 rs60233158 chr17:80896612 A/G cg15369054 chr17:80825471 TBCD -0.53 -8.47 -0.42 8.09e-16 Breast cancer; CRC cis rs1971762 0.542 rs12303370 chr12:54091807 A/C cg06632207 chr12:54070931 ATP5G2 0.37 6.52 0.34 2.67e-10 Height; CRC cis rs7811142 0.945 rs6955362 chr7:100056166 C/T cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.75 10.17 0.49 2.66e-21 Platelet count; CRC cis rs9443189 0.570 rs659807 chr6:76293435 C/A cg01950844 chr6:76311363 SENP6 0.74 9.8 0.48 4.62e-20 Prostate cancer; CRC cis rs185694 1.000 rs202101 chr13:30897337 A/G cg07600127 chr13:30881527 KATNAL1 -0.57 -5.99 -0.31 5.65e-9 Antineutrophil cytoplasmic antibody-associated vasculitis; CRC cis rs1552244 0.935 rs7618815 chr3:10151045 A/G cg18598329 chr3:10140678 FANCD2;C3orf24 -0.89 -11.93 -0.55 1.67e-27 Alzheimer's disease; CRC cis rs9467711 0.606 rs9357006 chr6:26364628 A/C cg16898833 chr6:26189333 HIST1H4D 0.76 6.58 0.34 1.84e-10 Autism spectrum disorder or schizophrenia; CRC cis rs910316 1.000 rs4899546 chr14:75594946 G/C cg03030879 chr14:75389066 RPS6KL1 -0.47 -7.44 -0.38 8.92e-13 Height; CRC cis rs7937682 0.562 rs7938620 chr11:111366844 G/A cg19812747 chr11:111475976 SIK2 0.46 7.22 0.37 3.58e-12 Primary sclerosing cholangitis; CRC cis rs7811142 0.830 rs11765869 chr7:99964789 T/G cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.93 11.94 0.55 1.48e-27 Platelet count; CRC cis rs9905704 0.918 rs304271 chr17:56802458 C/T cg12560992 chr17:57184187 TRIM37 0.53 7.31 0.37 1.99e-12 Testicular germ cell tumor; CRC cis rs2239547 0.522 rs4519686 chr3:52997871 C/T cg18404041 chr3:52824283 ITIH1 -0.36 -6.56 -0.34 2.08e-10 Schizophrenia; CRC trans rs629535 0.814 rs62513373 chr8:70080753 C/T cg21567404 chr3:27674614 NA -0.94 -15.18 -0.64 8.33e-40 Dupuytren's disease; CRC cis rs4601821 0.895 rs2155464 chr11:113242448 T/C cg14159747 chr11:113255604 NA 0.5 9.07 0.45 1.09e-17 Alcoholic chronic pancreatitis; CRC cis rs17270561 0.609 rs4712959 chr6:25727057 C/T cg17691542 chr6:26056736 HIST1H1C 0.73 9.31 0.46 1.82e-18 Iron status biomarkers; CRC cis rs11958404 0.932 rs113264420 chr5:157437779 T/C cg05962755 chr5:157440814 NA 0.95 12.34 0.56 5.17e-29 IgG glycosylation; CRC cis rs250677 0.687 rs2963484 chr5:148451127 A/T cg18129178 chr5:148520854 ABLIM3 -0.36 -5.64 -0.3 3.72e-8 Breast cancer; CRC cis rs995000 0.931 rs61471917 chr1:63084030 G/A cg19896129 chr1:63156450 NA 0.42 6.53 0.34 2.48e-10 Triglyceride levels; CRC cis rs2050392 0.789 rs303438 chr10:30733493 C/T cg18806716 chr10:30721971 MAP3K8 0.56 8.43 0.42 1.12e-15 Inflammatory bowel disease; CRC cis rs875971 0.545 rs7787063 chr7:65628999 G/A cg18876405 chr7:65276391 NA 0.45 6.17 0.32 1.96e-9 Aortic root size; CRC cis rs8058578 1.000 rs13338946 chr16:30700858 T/C cg02466173 chr16:30829666 NA -0.79 -12.36 -0.56 4.49e-29 Multiple myeloma; CRC cis rs9372498 0.536 rs62422228 chr6:118957276 T/C cg01339444 chr6:118972232 C6orf204 0.54 5.98 0.31 5.97e-9 Diastolic blood pressure; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg17825989 chr6:155635201 TFB1M 0.44 7.29 0.37 2.27e-12 Liver disease severity in Alagille syndrome; CRC cis rs9517320 0.534 rs4772088 chr13:99138270 T/G cg20487152 chr13:99095054 FARP1 -0.44 -6.4 -0.33 5.35e-10 Longevity; CRC cis rs9368481 0.761 rs9379952 chr6:26987900 A/T cg10547057 chr6:26987810 LOC100270746;C6orf41 -0.44 -6.25 -0.33 1.25e-9 Autism spectrum disorder or schizophrenia; CRC cis rs2580764 0.632 rs2588510 chr2:55199248 A/G cg09592903 chr2:55203963 RTN4 -0.74 -11.85 -0.55 3.25e-27 Mean platelet volume; CRC cis rs9611565 0.694 rs202639 chr22:41856137 T/A cg06481639 chr22:41940642 POLR3H 0.51 6.06 0.32 3.79e-9 Vitiligo; CRC cis rs9443645 0.527 rs9361479 chr6:79723755 T/A cg09184832 chr6:79620586 NA -0.45 -7.71 -0.39 1.52e-13 Intelligence (multi-trait analysis); CRC trans rs7395662 0.963 rs11039826 chr11:48572398 G/A cg21153622 chr11:89784906 NA -0.47 -7.49 -0.38 6.2e-13 HDL cholesterol; CRC cis rs853679 0.546 rs200996 chr6:27811828 G/A cg19041857 chr6:27730383 NA -0.73 -7.16 -0.37 5.2e-12 Depression; CRC cis rs7107174 0.901 rs10899493 chr11:78117534 T/C cg02023728 chr11:77925099 USP35 0.37 6.29 0.33 1.01e-9 Testicular germ cell tumor; CRC cis rs4563143 0.675 rs56322221 chr19:29270349 A/T cg03161606 chr19:29218774 NA 0.53 6.66 0.34 1.18e-10 Methadone dose in opioid dependence; CRC cis rs1448094 0.933 rs11836175 chr12:86311644 A/T cg19622623 chr12:86230825 RASSF9 -0.36 -5.81 -0.31 1.44e-8 Major depressive disorder; CRC cis rs73200209 0.744 rs55819608 chr12:116578300 C/T cg01776926 chr12:116560359 MED13L -0.57 -6.28 -0.33 1.06e-9 Total body bone mineral density; CRC cis rs2806561 0.929 rs6669568 chr1:23540469 G/A cg19743168 chr1:23544995 NA -0.37 -5.84 -0.31 1.24e-8 Height; CRC cis rs941873 0.805 rs8837 chr10:81114813 C/G cg09469691 chr10:81107165 PPIF 0.51 7.89 0.4 4.65e-14 Height; CRC cis rs9847710 0.967 rs2244552 chr3:53055522 A/G cg04503182 chr3:53078218 SFMBT1 0.41 6.55 0.34 2.16e-10 Ulcerative colitis; CRC cis rs2404602 0.647 rs116505114 chr15:77074794 T/C cg23625390 chr15:77176239 SCAPER -0.88 -14.5 -0.62 3.48e-37 Blood metabolite levels; CRC cis rs2625529 0.617 rs3784313 chr15:72187519 G/T cg16672083 chr15:72433130 SENP8 0.47 7.18 0.37 4.54e-12 Red blood cell count; CRC cis rs9733 0.596 rs56058687 chr1:150635066 C/T cg18016565 chr1:150552671 MCL1 0.46 6.74 0.35 6.91e-11 Tonsillectomy; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg14640386 chr17:5185735 RABEP1 0.38 6.25 0.33 1.25e-9 Liver disease severity in Alagille syndrome; CRC cis rs6499129 0.558 rs28711261 chr16:67617186 A/G cg26727032 chr16:67993705 SLC12A4 -0.6 -7.43 -0.38 9.58e-13 Waist-to-hip ratio adjusted for body mass index; CRC cis rs11112613 0.713 rs11112592 chr12:105951702 C/T cg03607813 chr12:105948248 NA -0.74 -10.57 -0.5 1.09e-22 Corrected insulin response;Corrected insulin response adjusted for insulin sensitivity index; CRC trans rs60843830 0.928 rs62114494 chr2:211317 C/T cg11347411 chr7:150020925 ACTR3C;LRRC61 0.58 8.73 0.43 1.3e-16 Spherical equivalent (joint analysis main effects and education interaction); CRC cis rs7131987 0.834 rs1989478 chr12:29442229 C/T cg09582351 chr12:29534625 ERGIC2 -0.35 -7.48 -0.38 6.72e-13 QT interval; CRC trans rs800082 0.507 rs1121562 chr3:144259665 A/G cg24215973 chr2:240111563 HDAC4 0.44 6.17 0.32 2.04e-9 Smoking behavior; CRC trans rs35110281 0.805 rs2838318 chr21:44991825 G/A cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.41 6.65 0.34 1.25e-10 Mean corpuscular volume; CRC cis rs7605827 0.897 rs1468912 chr2:15662922 A/G cg19274914 chr2:15703543 NA 0.39 5.84 0.31 1.23e-8 Educational attainment (years of education); CRC cis rs7512552 0.839 rs1498308 chr1:150295131 G/T cg15654264 chr1:150340011 RPRD2 0.58 8.66 0.43 2.18e-16 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); CRC cis rs11809207 0.523 rs7087 chr1:26496651 T/C cg00147160 chr1:26503991 CNKSR1 0.29 6.07 0.32 3.56e-9 Height; CRC cis rs514406 0.893 rs1242330 chr1:53396842 T/G cg24675658 chr1:53192096 ZYG11B -0.58 -8.54 -0.43 5.22e-16 Monocyte count; CRC cis rs6963495 0.818 rs56251768 chr7:105165591 A/G cg02135003 chr7:105160482 PUS7 -0.91 -12.41 -0.56 2.87e-29 Bipolar disorder (body mass index interaction); CRC cis rs2032447 0.507 rs478349 chr6:25894057 T/C cg04800585 chr6:26043546 HIST1H2BB 0.43 5.6 0.3 4.52e-8 Intelligence (multi-trait analysis); CRC cis rs4663866 0.803 rs71426511 chr2:239180200 G/A cg16914508 chr2:239161102 PER2 0.77 7.79 0.39 8.63e-14 Irritable bowel syndrome; CRC trans rs9858542 0.953 rs9837341 chr3:49664767 A/G cg21665057 chr3:196295764 WDR53;FBXO45 -0.69 -8.95 -0.44 2.61e-17 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs3771570 1.000 rs73020143 chr2:242261240 T/A cg21155796 chr2:242212141 HDLBP 0.64 6.97 0.36 1.72e-11 Prostate cancer; CRC cis rs801193 1.000 rs2286684 chr7:66129830 G/T cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.44 -6.46 -0.34 3.75e-10 Aortic root size; CRC cis rs9457247 0.646 rs239934 chr6:167412048 G/A cg23791538 chr6:167370224 RNASET2 -0.37 -5.67 -0.3 3.18e-8 Crohn's disease; CRC cis rs1707322 0.691 rs28495425 chr1:46187320 T/G cg03146154 chr1:46216737 IPP 0.68 9.94 0.48 1.59e-20 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs2735413 0.914 rs2262658 chr16:78060267 A/G cg04733911 chr16:78082701 NA -0.37 -6.01 -0.31 4.89e-9 Systolic blood pressure (alcohol consumption interaction); CRC trans rs6693295 0.711 rs4417032 chr1:246226428 G/A cg03680032 chr11:94965610 SESN3 0.46 5.99 0.31 5.35e-9 Migraine - clinic-based;Migraine with aura; CRC cis rs7973719 0.773 rs6486911 chr12:7356494 G/C cg07052231 chr12:7363540 PEX5 0.52 8.4 0.42 1.39e-15 IgG glycosylation; CRC cis rs738322 0.967 rs2092180 chr22:38571563 A/G cg17652424 chr22:38574118 PLA2G6 -0.22 -6.73 -0.35 7.71e-11 Cutaneous nevi; CRC cis rs853679 0.517 rs4713145 chr6:28106827 T/C cg25164649 chr6:28176230 NA 0.76 9.53 0.46 3.71e-19 Depression; CRC cis rs4481887 0.927 rs4376768 chr1:248476088 A/G cg13385794 chr1:248469461 NA -0.38 -6.67 -0.35 1.07e-10 Common traits (Other); CRC cis rs7927771 0.800 rs35996350 chr11:47389223 A/G cg18512352 chr11:47633146 NA -0.35 -6.74 -0.35 6.9e-11 Subjective well-being; CRC cis rs651907 0.557 rs34181125 chr3:101490278 A/G cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.65 9.06 0.45 1.2e-17 Colorectal cancer; CRC cis rs1387259 0.790 rs2732445 chr12:48645533 C/T cg04545296 chr12:48745243 ZNF641 0.36 6.18 0.32 1.85e-9 Obstructive sleep apnea trait (apnea hypopnea index); CRC cis rs514406 0.929 rs557715 chr1:53321593 C/G cg24675658 chr1:53192096 ZYG11B -0.54 -8.21 -0.41 5.1e-15 Monocyte count; CRC cis rs6964587 0.626 rs10234074 chr7:91520119 C/T cg17063962 chr7:91808500 NA -0.58 -9.22 -0.45 3.57e-18 Breast cancer; CRC cis rs875971 0.545 rs11770063 chr7:65783016 G/A cg18876405 chr7:65276391 NA 0.46 6.45 0.34 3.96e-10 Aortic root size; CRC cis rs7949030 0.688 rs11231155 chr11:62365619 A/G cg11742103 chr11:62369870 EML3;MTA2 0.61 11.79 0.54 5.38e-27 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; CRC cis rs10870270 0.956 rs7904594 chr10:133734671 C/T cg08754478 chr10:133766260 PPP2R2D -0.65 -9.43 -0.46 7.78e-19 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; CRC cis rs35306767 0.761 rs11253557 chr10:1043667 C/T cg20503657 chr10:835505 NA 0.93 11.21 0.53 6.41e-25 Eosinophil percentage of granulocytes; CRC cis rs6424115 0.800 rs2229581 chr1:24201094 G/C cg10978503 chr1:24200527 CNR2 0.61 11.06 0.52 2.22e-24 Immature fraction of reticulocytes; CRC cis rs765787 0.530 rs28756676 chr15:45540360 G/A cg24006582 chr15:45444508 DUOX1 -0.57 -8.63 -0.43 2.62e-16 Uric acid levels; CRC cis rs1348850 0.574 rs12988366 chr2:178417945 A/C cg27490568 chr2:178487706 NA -0.6 -7.41 -0.38 1.1e-12 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC trans rs7845127 0.635 rs7357551 chr8:18142268 A/C cg26673070 chr14:71828969 NA 0.51 6.01 0.31 4.92e-9 Night sleep phenotypes; CRC cis rs28386778 0.897 rs3744293 chr17:61841788 T/A cg06873352 chr17:61820015 STRADA 0.79 14.96 0.64 5.82e-39 Prudent dietary pattern; CRC cis rs1401999 1.000 rs1402002 chr3:183642794 A/G cg05044414 chr3:183734942 ABCC5 0.48 8.26 0.41 3.58e-15 Anterior chamber depth; CRC cis rs6089584 0.888 rs2146853 chr20:60617908 A/T cg18761221 chr20:60518478 NA 0.45 7.21 0.37 3.8e-12 Body mass index; CRC trans rs3942852 0.568 rs2904315 chr11:48109948 C/T cg03929089 chr4:120376271 NA 0.58 8.17 0.41 6.91e-15 Acute lymphoblastic leukemia (childhood); CRC trans rs66573146 1.000 rs6812771 chr4:6964048 G/A cg07817883 chr1:32538562 TMEM39B 1.51 13.3 0.59 1.33e-32 Granulocyte percentage of myeloid white cells; CRC cis rs1552244 0.935 rs2272124 chr3:10138189 T/C cg16606324 chr3:10149918 C3orf24 0.69 9.77 0.47 5.84e-20 Alzheimer's disease; CRC cis rs853679 0.569 rs9348798 chr6:28143011 G/A cg15786705 chr6:28176104 NA 0.78 9.7 0.47 1.01e-19 Depression; CRC trans rs6703335 0.870 rs10803142 chr1:243598234 A/G cg04827747 chr7:134855666 C7orf49 0.42 6.04 0.32 4.24e-9 Schizophrenia;Schizophrenia, schizoaffective disorder or bipolar disorder; CRC cis rs6500602 0.609 rs7202910 chr16:4518948 T/A cg06139259 chr16:4526053 HMOX2;NMRAL1 0.54 7.15 0.37 5.62e-12 Schizophrenia; CRC cis rs812925 0.537 rs2463097 chr2:61614301 G/C cg10580144 chr2:61372316 C2orf74 -0.33 -7.18 -0.37 4.56e-12 Immature fraction of reticulocytes; CRC cis rs17065868 0.764 rs73188732 chr13:45031653 G/A cg10246903 chr13:45222710 NA 0.54 5.69 0.3 2.79e-8 Antineutrophil cytoplasmic antibody-associated vasculitis; CRC cis rs67340775 0.541 rs200965 chr6:27866384 G/A cg26587870 chr6:27730563 NA -0.54 -6.09 -0.32 3.1e-9 Lung cancer in ever smokers; CRC cis rs7258465 1.000 rs4595905 chr19:18547305 T/A cg01065977 chr19:18549689 ISYNA1 -0.41 -6.23 -0.33 1.39e-9 Breast cancer; CRC cis rs7312933 0.526 rs1669892 chr12:42811305 G/A cg19980929 chr12:42632907 YAF2 -0.4 -6.19 -0.32 1.82e-9 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CRC cis rs2845885 0.793 rs56241103 chr11:63882364 C/T cg24431193 chr11:63883947 FLRT1;MACROD1 0.75 8.87 0.44 4.69e-17 Body mass index; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg00930347 chr6:110012366 AKD1;FIG4 0.48 6.17 0.32 2.01e-9 Thyroid stimulating hormone; CRC cis rs79349575 0.783 rs17708633 chr17:47011620 C/G cg00947319 chr17:47005597 UBE2Z -0.34 -5.89 -0.31 9.32e-9 Type 2 diabetes; CRC trans rs6600671 0.934 rs67718113 chr1:121238910 C/T cg09829573 chr1:144692074 NBPF9 0.42 6.17 0.32 1.97e-9 Hip geometry; CRC cis rs992157 0.835 rs7559416 chr2:219150211 A/G cg00012203 chr2:219082015 ARPC2 -0.47 -7.25 -0.37 2.95e-12 Colorectal cancer; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg10660249 chr9:5833007 ERMP1 0.46 6.54 0.34 2.3e-10 Response to antipsychotic treatment; CRC cis rs9916302 0.861 rs2338801 chr17:37490780 G/T cg03013999 chr17:37608204 MED1 -0.48 -7.35 -0.38 1.56e-12 Glomerular filtration rate (creatinine); CRC cis rs12230513 0.732 rs61956358 chr12:55852286 G/T cg19537932 chr12:55886519 OR6C68 -0.72 -9.37 -0.46 1.17e-18 Contrast sensitivity; CRC cis rs6570726 0.791 rs621382 chr6:145799144 T/C cg23711669 chr6:146136114 FBXO30 0.73 12.5 0.57 1.29e-29 Lobe attachment (rater-scored or self-reported); CRC cis rs7172809 0.796 rs4886870 chr15:77827471 A/C cg10437265 chr15:77819839 NA -0.4 -6.75 -0.35 6.52e-11 Glucose homeostasis traits; CRC cis rs2976388 0.578 rs13254358 chr8:143823876 G/A cg15511327 chr8:143859410 LYNX1 -0.39 -6.06 -0.32 3.74e-9 Urinary tract infection frequency; CRC cis rs2576037 0.562 rs612519 chr18:44379490 G/A cg19077165 chr18:44547161 KATNAL2 -0.59 -9.64 -0.47 1.59e-19 Personality dimensions; CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg23392782 chr16:88772647 RNF166;CTU2 -0.6 -7.58 -0.39 3.59e-13 Diisocyanate-induced asthma; CRC cis rs12908161 0.959 rs12906348 chr15:85329421 A/C cg17507749 chr15:85114479 UBE2QP1 0.62 8.8 0.44 7.93e-17 Schizophrenia; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg09955859 chr1:40626914 RLF 0.53 7.68 0.39 1.89e-13 Response to antipsychotic treatment; CRC cis rs4728142 0.584 rs7796963 chr7:128629001 T/C cg06630958 chr7:128577819 IRF5 -0.35 -5.65 -0.3 3.55e-8 Inflammatory bowel disease;Systemic lupus erythematosus;Ulcerative colitis; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg08301941 chr17:42148070 G6PC3 0.45 6.45 0.34 3.99e-10 Response to antipsychotic treatment; CRC cis rs7937682 0.883 rs568038 chr11:111432161 A/C cg19812747 chr11:111475976 SIK2 0.52 8.64 0.43 2.47e-16 Primary sclerosing cholangitis; CRC cis rs4604732 0.527 rs12031949 chr1:247624463 G/T cg12754571 chr1:247694271 LOC148824;OR2C3 0.41 5.8 0.3 1.56e-8 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CRC cis rs56235845 0.964 rs11746443 chr5:176798306 G/A cg14427527 chr5:176793960 RGS14 0.38 5.62 0.3 4.12e-8 Hemoglobin concentration;Hematocrit; CRC trans rs4711350 1.000 rs2395447 chr6:33743174 T/C cg14318858 chr19:50204862 CPT1C -0.37 -6.04 -0.32 4.26e-9 Schizophrenia; CRC cis rs2242116 0.796 rs7623898 chr3:46974172 C/T cg02527881 chr3:46936655 PTH1R 0.49 8.87 0.44 4.69e-17 Birth weight; CRC cis rs7811142 1.000 rs67315960 chr7:100015124 A/G cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.63 8.16 0.41 7.42e-15 Platelet count; CRC cis rs12995491 0.731 rs55705009 chr2:88500718 T/G cg18490616 chr2:88469792 THNSL2 -0.42 -6.12 -0.32 2.64e-9 Response to metformin (IC50); CRC cis rs10484885 0.878 rs111664889 chr6:90566427 G/T cg13799429 chr6:90582589 CASP8AP2 -0.72 -7.69 -0.39 1.76e-13 QRS interval (sulfonylurea treatment interaction); CRC cis rs12545109 0.800 rs1837614 chr8:57414497 T/A cg09654669 chr8:57350985 NA -0.45 -7.22 -0.37 3.56e-12 Obesity-related traits; CRC cis rs826838 0.900 rs1403523 chr12:39130570 T/A cg26384229 chr12:38710491 ALG10B -0.64 -9.67 -0.47 1.21e-19 Heart rate; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg07191003 chr1:1334791 CCNL2;LOC148413 0.46 6.17 0.32 1.96e-9 Anxiety disorder; CRC cis rs10504229 0.953 rs75253516 chr8:58171547 C/A cg22535103 chr8:58192502 C8orf71 -0.81 -11.92 -0.55 1.86e-27 Developmental language disorder (linguistic errors); CRC cis rs7927771 0.832 rs7940536 chr11:47395240 G/A cg20307385 chr11:47447363 PSMC3 0.62 9.27 0.46 2.44e-18 Subjective well-being; CRC cis rs929354 0.742 rs2107863 chr7:156963731 T/C cg16102536 chr7:156981717 UBE3C 0.4 6.69 0.35 9.57e-11 Body mass index; CRC cis rs2228479 0.681 rs11641790 chr16:89961957 A/G cg04013166 chr16:89971882 TCF25 -0.69 -8.75 -0.43 1.11e-16 Skin colour saturation; CRC cis rs1816752 0.905 rs3818938 chr13:25029083 C/T cg02811702 chr13:24901961 NA 0.41 5.73 0.3 2.33e-8 Obesity-related traits; CRC trans rs8073060 0.586 rs72828038 chr17:33893908 C/A cg19694781 chr19:47549865 TMEM160 0.97 13.29 0.59 1.43e-32 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; CRC cis rs10256972 0.591 rs10229680 chr7:1158565 C/T cg04025307 chr7:1156635 C7orf50 0.78 12.74 0.57 1.78e-30 Longevity;Endometriosis; CRC cis rs2404602 0.692 rs35395069 chr15:76986334 C/T cg22467129 chr15:76604101 ETFA -0.41 -6.81 -0.35 4.6e-11 Blood metabolite levels; CRC cis rs826838 0.900 rs11169301 chr12:39128497 C/A cg26384229 chr12:38710491 ALG10B 0.72 9.93 0.48 1.66e-20 Heart rate; CRC cis rs7487075 0.786 rs11183441 chr12:46715920 G/A cg22049899 chr12:47219821 SLC38A4 0.34 6.54 0.34 2.31e-10 Itch intensity from mosquito bite; CRC cis rs589448 0.934 rs554591 chr12:69753847 T/C cg22834771 chr12:69754056 YEATS4 -0.56 -8.78 -0.44 9.17e-17 Cerebrospinal fluid biomarker levels; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg26462404 chr19:2270807 OAZ1 0.45 6.34 0.33 7.52e-10 Response to antipsychotic treatment; CRC cis rs7584330 0.657 rs10202599 chr2:238352465 A/C cg16989719 chr2:238392110 NA -0.46 -8.48 -0.42 7.82e-16 Prostate cancer; CRC cis rs950169 0.580 rs11633762 chr15:85187152 T/C cg11189052 chr15:85197271 WDR73 0.65 9.32 0.46 1.75e-18 Schizophrenia; CRC cis rs3733585 0.605 rs56178126 chr4:10123581 C/T cg00071950 chr4:10020882 SLC2A9 -0.56 -8.77 -0.44 9.74e-17 Cleft plate (environmental tobacco smoke interaction); CRC cis rs12024301 0.557 rs12032504 chr1:183602308 A/C cg11505048 chr1:183622726 RGL1;APOBEC4 -0.74 -6.53 -0.34 2.51e-10 Peripheral arterial disease (traffic-related air pollution interaction); CRC trans rs6546324 0.625 rs2861703 chr2:67861053 T/C cg00907274 chr3:27498161 SLC4A7 -0.48 -6.11 -0.32 2.85e-9 Endometriosis; CRC cis rs13118159 0.573 rs4974618 chr4:1373663 C/T cg02475777 chr4:1388615 CRIPAK 0.5 6.43 0.33 4.49e-10 Longevity; CRC cis rs2836974 0.965 rs8131126 chr21:40655754 A/G cg07074390 chr21:40555500 PSMG1 -0.45 -5.98 -0.31 5.86e-9 Cognitive function; CRC cis rs780096 0.526 rs704795 chr2:27716494 G/A cg24768116 chr2:27665128 KRTCAP3 -0.35 -7.86 -0.4 5.36e-14 Total body bone mineral density; CRC cis rs6570726 0.905 rs1355146 chr6:145781741 A/C cg05347473 chr6:146136440 FBXO30 -0.39 -6.11 -0.32 2.85e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs916888 0.773 rs199451 chr17:44801784 G/A cg01570182 chr17:44337453 NA 1.24 14.35 0.62 1.29e-36 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs4713118 0.869 rs6914924 chr6:27711530 C/T cg15786705 chr6:28176104 NA 0.54 7.62 0.39 2.72e-13 Parkinson's disease; CRC cis rs10751667 0.666 rs7395321 chr11:940280 C/T cg01483505 chr11:975446 AP2A2 0.44 7.24 0.37 3.16e-12 Alzheimer's disease (late onset); CRC cis rs853679 0.546 rs200981 chr6:27833174 A/G cg23259851 chr6:27775964 HIST1H2AI;HIST1H2BL 0.67 5.73 0.3 2.3e-8 Depression; CRC cis rs2243480 0.901 rs778730 chr7:65823325 T/A cg12463550 chr7:65579703 CRCP 0.73 6.54 0.34 2.35e-10 Diabetic kidney disease; CRC trans rs7395662 0.591 rs11039766 chr11:48488715 T/C cg03929089 chr4:120376271 NA -0.47 -6.72 -0.35 7.83e-11 HDL cholesterol; CRC cis rs637571 0.522 rs556643 chr11:65733289 C/T cg26695010 chr11:65641043 EFEMP2 -0.39 -5.95 -0.31 6.93e-9 Eosinophil percentage of white cells; CRC cis rs853679 0.527 rs213228 chr6:28331252 A/C cg15845792 chr6:28175446 NA 0.43 5.81 0.31 1.45e-8 Depression; CRC cis rs9309473 1.000 rs10187192 chr2:73713500 T/C cg20560298 chr2:73613845 ALMS1 -0.52 -5.87 -0.31 1.06e-8 Metabolite levels; CRC cis rs4423214 1.000 rs7928249 chr11:71161063 A/G cg05163923 chr11:71159392 DHCR7 0.68 9.7 0.47 9.56e-20 Vitamin D levels; CRC cis rs896854 0.875 rs4735333 chr8:95955074 G/A cg13393036 chr8:95962371 TP53INP1 -0.52 -8.95 -0.44 2.69e-17 Type 2 diabetes; CRC cis rs9303401 0.527 rs12939313 chr17:56755616 A/T cg02118635 chr17:56770003 RAD51C;TEX14 0.78 8.97 0.44 2.27e-17 Cognitive test performance; CRC cis rs7811142 1.000 rs4989959 chr7:100032288 T/C cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.62 8.09 0.41 1.16e-14 Platelet count; CRC cis rs4561483 0.645 rs2192645 chr16:11928019 C/T cg08843971 chr16:11963173 GSPT1 -0.46 -7.07 -0.36 9.32e-12 Testicular germ cell tumor; CRC cis rs7786808 0.608 rs9692003 chr7:158204696 G/A cg01191920 chr7:158217561 PTPRN2 0.59 9.46 0.46 6.08e-19 Obesity-related traits; CRC cis rs62064224 0.509 rs2302276 chr17:30791503 C/T cg18200150 chr17:30822561 MYO1D 0.49 9.67 0.47 1.26e-19 Schizophrenia; CRC cis rs1707322 1.000 rs6657720 chr1:46386269 G/A cg06784218 chr1:46089804 CCDC17 0.51 8.98 0.44 2.07e-17 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs7103648 0.966 rs10838702 chr11:47410888 G/T cg20307385 chr11:47447363 PSMC3 0.96 17.13 0.69 1.83e-47 Diastolic blood pressure;Systolic blood pressure; CRC cis rs1046896 0.553 rs72634343 chr17:80827392 T/C cg03160526 chr17:80928410 B3GNTL1 0.57 7.74 0.39 1.25e-13 Glycated hemoglobin levels; CRC cis rs1707322 0.896 rs785512 chr1:46534543 A/G cg06784218 chr1:46089804 CCDC17 -0.54 -9.38 -0.46 1.08e-18 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs3740540 0.530 rs10794163 chr10:126291398 A/G cg04949429 chr10:126290192 LHPP 0.42 6.23 0.32 1.45e-9 Obesity-related traits;Acute lymphoblastic leukemia (childhood); CRC trans rs7615952 0.512 rs4679430 chr3:125357893 T/C cg17147758 chr8:6949321 NA -0.52 -7.2 -0.37 4.24e-12 Blood pressure (smoking interaction); CRC trans rs5756813 0.688 rs2413483 chr22:38127950 C/T cg19894588 chr14:64061835 NA -0.58 -7.64 -0.39 2.45e-13 Optic cup area;Vertical cup-disc ratio; CRC cis rs3785574 0.962 rs62077512 chr17:61851435 C/T cg23090583 chr17:61904693 PSMC5;FTSJ3 0.65 9.57 0.47 2.57e-19 Height; CRC cis rs78456975 1.000 rs78456975 chr2:1554190 T/G cg26248373 chr2:1572462 NA -0.66 -7.1 -0.36 7.65e-12 Placebo response in major depressive disorder (% change in symptom score); CRC cis rs12144094 1.000 rs12144094 chr1:120264823 C/G cg20995928 chr1:120229863 NA 0.48 5.73 0.3 2.31e-8 Height; CRC cis rs11585357 0.947 rs2977304 chr1:17611615 T/C cg08277548 chr1:17600880 PADI3 0.69 9.48 0.46 5.28e-19 Hair shape; CRC cis rs1865760 1.000 rs3752421 chr6:25918688 G/A cg17691542 chr6:26056736 HIST1H1C 0.56 8.43 0.42 1.08e-15 Height; CRC cis rs870825 0.932 rs28594349 chr4:185574415 G/A cg04058563 chr4:185651563 MLF1IP 0.63 6.41 0.33 4.97e-10 Blood protein levels; CRC trans rs9291683 0.609 rs12500810 chr4:10031068 G/A cg26043149 chr18:55253948 FECH 0.53 8.22 0.41 4.65e-15 Bone mineral density; CRC trans rs1864729 0.901 rs1348184 chr8:98276912 C/G cg08679828 chr8:102218111 ZNF706 -0.61 -7.34 -0.38 1.67e-12 Estradiol plasma levels (breast cancer); CRC cis rs45544231 0.544 rs4783780 chr16:52571436 G/T cg09051775 chr16:52580266 TOX3 0.39 6.35 0.33 7.12e-10 Restless legs syndrome; CRC trans rs10802346 0.545 rs1770003 chr1:246408356 A/G cg13514129 chr1:39547527 MACF1 0.63 9.41 0.46 8.86e-19 Fractional exhaled nitric oxide (childhood); CRC cis rs977987 0.778 rs1109341 chr16:75445605 G/A cg03315344 chr16:75512273 CHST6 0.54 9.07 0.45 1.09e-17 Dupuytren's disease; CRC cis rs995000 0.895 rs1168124 chr1:63139730 C/T cg19896129 chr1:63156450 NA -0.43 -6.58 -0.34 1.88e-10 Triglyceride levels; CRC cis rs9611565 0.546 rs739132 chr22:42123099 A/T cg06634786 chr22:41940651 POLR3H 0.64 7.32 0.37 1.94e-12 Vitiligo; CRC cis rs1865760 0.963 rs3846838 chr6:25911775 T/C cg17691542 chr6:26056736 HIST1H1C 0.56 8.43 0.42 1.1e-15 Height; CRC cis rs7786808 0.608 rs7784758 chr7:158214386 A/G cg01191920 chr7:158217561 PTPRN2 -0.57 -9.22 -0.45 3.7e-18 Obesity-related traits; CRC cis rs4713118 0.614 rs9380007 chr6:27660508 T/C cg02683197 chr6:28174875 NA 0.56 8.01 0.4 2.06e-14 Parkinson's disease; CRC cis rs7824557 0.564 rs2736290 chr8:11234298 C/T cg20542592 chr8:11973495 FAM66D 0.33 5.84 0.31 1.24e-8 Retinal vascular caliber; CRC cis rs9291683 0.588 rs12506364 chr4:10023448 C/T cg00071950 chr4:10020882 SLC2A9 0.67 13.0 0.58 1.85e-31 Bone mineral density; CRC cis rs12983728 0.831 rs79222418 chr19:58664418 T/C cg08687515 chr19:58661962 ZNF329 0.76 8.26 0.41 3.58e-15 Cholesterol, total; CRC cis rs6694672 0.867 rs1759013 chr1:197023411 T/G cg13682187 chr1:196946512 CFHR5 0.43 6.92 0.36 2.35e-11 Asthma; CRC cis rs11190604 1.000 rs17113137 chr10:102241998 G/C cg16342193 chr10:102329863 NA -0.36 -5.87 -0.31 1.07e-8 Palmitoleic acid (16:1n-7) levels; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg21937169 chr7:65541137 ASL 0.41 6.01 0.31 4.93e-9 Intelligence (multi-trait analysis); CRC cis rs6540559 0.673 rs926346 chr1:209962204 A/T cg23283495 chr1:209979779 IRF6 0.48 6.82 0.35 4.28e-11 Cleft lip with or without cleft palate; CRC cis rs6964587 1.000 rs415 chr7:91580490 A/G cg17063962 chr7:91808500 NA -0.79 -13.8 -0.61 1.73e-34 Breast cancer; CRC cis rs7615952 0.932 rs7629977 chr3:125649573 T/G cg05084668 chr3:125655381 ALG1L -0.63 -9.83 -0.48 3.57e-20 Blood pressure (smoking interaction); CRC cis rs9648716 1.000 rs1267602 chr7:140544404 C/T cg10747023 chr7:140774559 NA 0.43 5.61 0.3 4.2e-8 Type 2 diabetes; CRC cis rs3785574 0.962 rs2955235 chr17:61966950 A/C cg06873352 chr17:61820015 STRADA 0.46 7.14 0.37 5.89e-12 Height; CRC cis rs7312933 0.510 rs61942483 chr12:42499538 T/A cg17420585 chr12:42539391 GXYLT1 -0.69 -12.32 -0.56 6.28e-29 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CRC cis rs6582630 0.554 rs8189625 chr12:38401177 C/T cg26384229 chr12:38710491 ALG10B -0.52 -7.54 -0.38 4.69e-13 Drug-induced liver injury (flucloxacillin); CRC cis rs514406 0.893 rs1242330 chr1:53396842 T/G cg08859206 chr1:53392774 SCP2 -0.48 -7.53 -0.38 4.8e-13 Monocyte count; CRC cis rs60733400 0.500 rs72644697 chr1:2533605 G/A cg18854424 chr1:2615690 NA 0.4 7.64 0.39 2.32e-13 Multiple sclerosis; CRC cis rs4711350 0.765 rs2395446 chr6:33743264 C/T cg07979401 chr6:33739406 LEMD2 -0.46 -6.11 -0.32 2.79e-9 Schizophrenia; CRC cis rs2777491 1.000 rs66538814 chr15:41685917 G/T cg18705301 chr15:41695430 NDUFAF1 -0.71 -12.12 -0.56 3.28e-28 Ulcerative colitis; CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg17422427 chr2:241507521 RNPEPL1 -0.52 -6.21 -0.32 1.57e-9 Diisocyanate-induced asthma; CRC cis rs2075371 0.796 rs35440439 chr7:134006094 C/T cg11752832 chr7:134001865 SLC35B4 0.43 6.46 0.34 3.69e-10 Mean platelet volume; CRC cis rs9826463 0.757 rs60001529 chr3:142282717 G/A cg20824294 chr3:142316082 PLS1 0.42 6.99 0.36 1.54e-11 QRS duration in Tripanosoma cruzi seropositivity; CRC cis rs10174077 0.874 rs10186656 chr2:152475938 T/G cg19508488 chr2:152266495 RIF1 0.5 6.95 0.36 1.92e-11 Squamous cell lung carcinoma; CRC cis rs282587 0.569 rs413110 chr13:113413755 A/G cg04656015 chr13:113407548 ATP11A -0.54 -6.62 -0.34 1.43e-10 Glycated hemoglobin levels; CRC cis rs2386661 1.000 rs2386661 chr10:5670275 A/G cg26603656 chr10:5671107 NA 0.48 7.95 0.4 2.95e-14 Breast cancer; CRC trans rs6951245 0.882 rs10256720 chr7:1210825 C/G cg13565492 chr6:43139072 SRF -0.69 -7.37 -0.38 1.37e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs11112613 0.713 rs73184082 chr12:105951748 T/C cg03607813 chr12:105948248 NA 0.77 10.73 0.51 3.22e-23 Corrected insulin response;Corrected insulin response adjusted for insulin sensitivity index; CRC cis rs2969070 1.000 rs1548594 chr7:2513281 G/C cg03277898 chr7:2518824 NA -0.45 -6.65 -0.34 1.21e-10 Diastolic blood pressure; CRC cis rs617791 0.669 rs4994056 chr11:65750997 G/A cg02427764 chr11:65769310 BANF1;EIF1AD 0.39 5.7 0.3 2.61e-8 Breast cancer; CRC cis rs1580019 0.587 rs6968990 chr7:32552159 C/T cg07520158 chr7:32535189 LSM5;AVL9 -0.52 -7.94 -0.4 3.25e-14 Cognitive ability; CRC cis rs28829049 0.566 rs59681755 chr1:19528985 G/A cg13387374 chr1:19411106 UBR4 0.41 6.06 0.32 3.79e-9 QRS duration in Tripanosoma cruzi seropositivity; CRC trans rs561341 1.000 rs542132 chr17:30307193 A/T cg20587970 chr11:113659929 NA -1.43 -20.43 -0.75 1.7e-60 Hip circumference adjusted for BMI; CRC cis rs637571 0.726 rs689274 chr11:65665988 A/G cg04055107 chr11:65626734 MUS81;CFL1 -0.43 -6.04 -0.32 4.08e-9 Eosinophil percentage of white cells; CRC cis rs995000 0.868 rs1168029 chr1:62969402 G/A cg19896129 chr1:63156450 NA -0.39 -6.04 -0.32 4.19e-9 Triglyceride levels; CRC trans rs783540 0.967 rs55972423 chr15:83258954 C/G cg18393722 chr15:85113863 UBE2QP1 -0.37 -6.29 -0.33 1.04e-9 Schizophrenia; CRC cis rs3806843 0.518 rs2569188 chr5:140008419 G/A cg19875535 chr5:140030758 IK -0.51 -8.16 -0.41 7.11e-15 Depressive symptoms (multi-trait analysis); CRC cis rs524023 0.957 rs538737 chr11:64355772 C/G cg06522879 chr11:64358276 SLC22A12 0.56 8.72 0.43 1.38e-16 Urate levels in obese individuals; CRC cis rs12620999 0.555 rs4073396 chr2:238111471 A/C cg15867307 chr2:238110829 NA -0.43 -7.18 -0.37 4.64e-12 Systemic lupus erythematosus; CRC trans rs9467711 0.606 rs9358939 chr6:26416787 C/G cg06606381 chr12:133084897 FBRSL1 -0.83 -6.42 -0.33 4.83e-10 Autism spectrum disorder or schizophrenia; CRC cis rs10256972 0.706 rs12701970 chr7:1121958 T/C cg07092213 chr7:1199455 ZFAND2A -0.42 -5.9 -0.31 8.87e-9 Longevity;Endometriosis; CRC cis rs6570726 0.764 rs4896821 chr6:145896181 G/A cg23711669 chr6:146136114 FBXO30 0.68 11.39 0.53 1.44e-25 Lobe attachment (rater-scored or self-reported); CRC cis rs9467711 0.651 rs34116162 chr6:25937652 G/A cg08501292 chr6:25962987 TRIM38 1.1 9.62 0.47 1.77e-19 Autism spectrum disorder or schizophrenia; CRC cis rs1534166 0.647 rs1464937 chr3:133536655 C/G cg08048268 chr3:133502702 NA 0.41 7.25 0.37 2.91e-12 Alcohol consumption (transferrin glycosylation); CRC cis rs41271951 0.512 rs7537292 chr1:151071038 C/G cg11822372 chr1:151115635 SEMA6C -0.71 -5.72 -0.3 2.34e-8 Blood protein levels; CRC cis rs10924970 0.649 rs12022924 chr1:235380147 G/T cg09010748 chr1:235293032 TOMM20 -0.42 -5.87 -0.31 1.07e-8 Asthma; CRC trans rs17807624 1.000 rs17807624 chr8:11463015 A/G cg06636001 chr8:8085503 FLJ10661 -0.51 -7.27 -0.37 2.61e-12 Systemic lupus erythematosus; CRC cis rs7666738 0.830 rs7669407 chr4:98750251 G/A cg05340658 chr4:99064831 C4orf37 0.54 8.0 0.4 2.21e-14 Colonoscopy-negative controls vs population controls; CRC cis rs1799949 1.000 rs12944597 chr17:41187684 A/C cg23758822 chr17:41437982 NA 0.82 13.33 0.59 1e-32 Menopause (age at onset); CRC cis rs8060686 0.641 rs76595854 chr16:68130233 T/C cg26727032 chr16:67993705 SLC12A4 -0.55 -6.3 -0.33 9.82e-10 HDL cholesterol;Metabolic syndrome; CRC cis rs7107174 0.681 rs3102742 chr11:77949334 G/T cg02023728 chr11:77925099 USP35 0.53 7.46 0.38 7.73e-13 Testicular germ cell tumor; CRC cis rs75422866 0.867 rs73104116 chr12:48078806 A/G cg14736327 chr12:48174669 SLC48A1 -0.79 -6.01 -0.31 4.92e-9 Pneumonia; CRC cis rs6564851 0.506 rs56389890 chr16:81259266 G/T cg05274606 chr16:81253692 PKD1L2 -0.38 -6.28 -0.33 1.05e-9 Carotenoid and tocopherol levels; CRC cis rs4713118 0.527 rs9461433 chr6:28095172 C/T cg23161317 chr6:28129485 ZNF389 0.53 6.54 0.34 2.37e-10 Parkinson's disease; CRC cis rs10540 0.730 rs12789735 chr11:518509 G/A cg19913688 chr11:428466 ANO9 -0.68 -6.94 -0.36 2.06e-11 Body mass index; CRC cis rs7193541 0.684 rs9929496 chr16:74668473 G/A cg01733217 chr16:74700730 RFWD3 1.05 21.31 0.76 6.21e-64 Multiple myeloma; CRC cis rs7208859 0.673 rs9913782 chr17:29237384 A/G cg01831904 chr17:28903510 LRRC37B2 -0.56 -5.83 -0.31 1.35e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs1005277 0.579 rs2474568 chr10:38383147 A/T cg17219203 chr10:38645113 HSD17B7P2 -0.4 -5.61 -0.3 4.34e-8 Extrinsic epigenetic age acceleration; CRC cis rs17685 0.753 rs4732542 chr7:75663203 A/G cg16489192 chr7:75678113 MDH2;STYXL1 -0.36 -5.68 -0.3 2.96e-8 Coffee consumption;Coffee consumption (cups per day); CRC cis rs644799 1.000 rs488246 chr11:95560473 T/C cg25478527 chr11:95522999 CEP57;FAM76B 0.52 7.86 0.4 5.6e-14 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg06614563 chr5:89770451 MBLAC2;POLR3G 0.45 6.31 0.33 8.98e-10 Response to antipsychotic treatment; CRC cis rs12024301 0.557 rs16861298 chr1:183598181 T/C cg11505048 chr1:183622726 RGL1;APOBEC4 0.76 6.93 0.36 2.16e-11 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs12410462 0.681 rs76191945 chr1:227673919 A/G cg23173402 chr1:227635558 NA 0.85 8.6 0.43 3.26e-16 Major depressive disorder; CRC cis rs2066819 1.000 rs79101914 chr12:56729739 A/G cg26714650 chr12:56694279 CS -1.41 -11.53 -0.54 4.75e-26 Psoriasis vulgaris; CRC trans rs7267979 1.000 rs2258201 chr20:25272490 G/C cg17903999 chr18:56338584 MALT1 -0.41 -6.92 -0.36 2.32e-11 Liver enzyme levels (alkaline phosphatase); CRC cis rs9534288 0.619 rs6561292 chr13:46683560 G/T cg15192986 chr13:46630673 CPB2 0.59 8.32 0.42 2.38e-15 Blood protein levels; CRC cis rs3733585 0.699 rs10017674 chr4:9967053 T/C cg11266682 chr4:10021025 SLC2A9 -0.47 -9.55 -0.47 3.01e-19 Cleft plate (environmental tobacco smoke interaction); CRC cis rs1005277 0.563 rs2505216 chr10:38482830 T/C cg17219203 chr10:38645113 HSD17B7P2 -0.4 -5.61 -0.3 4.37e-8 Extrinsic epigenetic age acceleration; CRC cis rs9660992 0.573 rs7368327 chr1:205214792 C/T cg21643547 chr1:205240462 TMCC2 -0.37 -6.06 -0.32 3.83e-9 Mean corpuscular volume;Mean platelet volume; CRC cis rs9486715 0.867 rs7451950 chr6:96879974 T/C cg18709589 chr6:96969512 KIAA0776 0.47 7.01 0.36 1.34e-11 Headache; CRC cis rs11608355 0.846 rs60945232 chr12:109854401 A/G cg19025524 chr12:109796872 NA -0.45 -5.96 -0.31 6.61e-9 Neuroticism; CRC cis rs1707322 0.716 rs6699444 chr1:46135120 G/C cg06784218 chr1:46089804 CCDC17 0.65 12.18 0.56 2e-28 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs7605827 0.930 rs11674824 chr2:15537429 G/A cg19274914 chr2:15703543 NA 0.4 5.94 0.31 7.2e-9 Educational attainment (years of education); CRC cis rs425277 1.000 rs436045 chr1:2071556 A/G cg24578937 chr1:2090814 PRKCZ -0.66 -11.81 -0.55 4.56e-27 Height; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg06391473 chr2:238875301 UBE2F 0.43 6.85 0.35 3.64e-11 Liver disease severity in Alagille syndrome; CRC cis rs9733 0.565 rs7524620 chr1:150616699 C/T cg17724175 chr1:150552817 MCL1 -0.56 -9.11 -0.45 8.18e-18 Tonsillectomy; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg04122601 chr12:10826785 STYK1 0.54 7.67 0.39 1.92e-13 Response to antipsychotic treatment; CRC cis rs875971 0.638 rs35986979 chr7:66088990 G/A cg00343986 chr7:65444356 GUSB -0.51 -7.61 -0.39 2.88e-13 Aortic root size; CRC cis rs13108904 0.901 rs7668661 chr4:1300172 A/G cg15763984 chr4:1342303 KIAA1530 0.35 6.17 0.32 2.06e-9 Obesity-related traits; CRC trans rs6897795 1.000 rs72648830 chr5:177608542 C/T cg19598605 chr2:70056955 GMCL1 -0.68 -7.68 -0.39 1.86e-13 Plateletcrit; CRC trans rs561341 1.000 rs560132 chr17:30320019 C/T cg27661571 chr11:113659931 NA -0.94 -11.03 -0.52 2.83e-24 Hip circumference adjusted for BMI; CRC cis rs55665837 1.000 rs12804549 chr11:14437758 A/T cg19336497 chr11:14380999 RRAS2 -0.38 -6.55 -0.34 2.25e-10 Vitamin D levels; CRC cis rs7618915 0.508 rs12498066 chr3:52627660 G/A cg18099408 chr3:52552593 STAB1 -0.44 -7.27 -0.37 2.7e-12 Bipolar disorder; CRC cis rs832540 0.931 rs33318 chr5:56208414 G/T cg12311346 chr5:56204834 C5orf35 -0.51 -7.92 -0.4 3.59e-14 Coronary artery disease; CRC cis rs9733 0.596 rs7538493 chr1:150655421 T/C cg10589385 chr1:150898437 SETDB1 0.28 5.98 0.31 5.86e-9 Tonsillectomy; CRC cis rs7666738 0.830 rs2098934 chr4:98992403 A/G cg17366294 chr4:99064904 C4orf37 0.44 7.39 0.38 1.19e-12 Colonoscopy-negative controls vs population controls; CRC cis rs7605827 0.930 rs11694485 chr2:15676154 C/T cg19274914 chr2:15703543 NA 0.39 5.8 0.3 1.53e-8 Educational attainment (years of education); CRC cis rs17713451 0.555 rs111386955 chr7:151270268 A/G cg18404559 chr7:151322523 PRKAG2 -0.57 -6.41 -0.33 5.12e-10 Interleukin-4 levels; CRC cis rs1552244 0.882 rs13084194 chr3:10031492 T/A cg18598329 chr3:10140678 FANCD2;C3orf24 -0.74 -8.88 -0.44 4.44e-17 Alzheimer's disease; CRC trans rs1814175 0.645 rs847639 chr11:49919603 C/T cg11707556 chr5:10655725 ANKRD33B -0.52 -9.95 -0.48 1.49e-20 Height; CRC cis rs3771570 1.000 rs73004382 chr2:242382192 C/T cg21155796 chr2:242212141 HDLBP 0.64 6.97 0.36 1.69e-11 Prostate cancer; CRC cis rs514406 0.698 rs567880 chr1:53348564 T/G cg08859206 chr1:53392774 SCP2 -0.59 -9.38 -0.46 1.09e-18 Monocyte count; CRC cis rs34779708 0.966 rs1213392 chr10:35430285 C/T cg03585969 chr10:35415529 CREM 0.54 7.21 0.37 3.9e-12 Inflammatory bowel disease;Crohn's disease; CRC cis rs4766566 0.501 rs3742004 chr12:111798553 A/G cg10833066 chr12:111807467 FAM109A 0.55 7.38 0.38 1.28e-12 Atrial fibrillation;Renal underexcretion gout;Gout;Renal overload gout; CRC cis rs58649573 0.574 rs10818907 chr9:126770250 C/G cg14112217 chr9:126806003 NA -0.41 -6.08 -0.32 3.36e-9 Post-traumatic stress disorder; CRC cis rs4689388 0.926 rs28420833 chr4:6279504 G/A cg14416269 chr4:6271139 WFS1 0.39 6.42 0.33 4.87e-10 Type 2 diabetes and other traits;Type 2 diabetes; CRC cis rs10256972 0.706 rs4285396 chr7:1123738 A/G cg04025307 chr7:1156635 C7orf50 0.7 11.11 0.52 1.51e-24 Longevity;Endometriosis; CRC cis rs9463078 0.656 rs227838 chr6:44684621 C/A cg25276700 chr6:44698697 NA 0.25 5.93 0.31 7.83e-9 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; CRC cis rs7605827 0.897 rs4459705 chr2:15526584 C/T cg19274914 chr2:15703543 NA 0.39 5.9 0.31 8.92e-9 Educational attainment (years of education); CRC cis rs9457247 0.602 rs12208359 chr6:167458455 G/A cg07741184 chr6:167504864 NA 0.42 7.04 0.36 1.13e-11 Crohn's disease; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg00311046 chr10:7830420 KIN;ATP5C1 0.41 6.03 0.32 4.46e-9 Intelligence (multi-trait analysis); CRC cis rs10540 1.000 rs12786555 chr11:506229 C/T cg03576123 chr11:487126 PTDSS2 -1.04 -10.79 -0.51 1.91e-23 Body mass index; CRC cis rs7385804 0.796 rs221801 chr7:100290031 C/A cg20848291 chr7:100343083 ZAN 0.49 7.49 0.38 6.36e-13 Iron status biomarkers;Mean corpuscular hemoglobin;Hematocrit;Iron status biomarkers (transferrin saturation);Red blood cell count;Iron status biomarkers (iron levels);Mean corpuscular volume;Hematological parameters; CRC cis rs6752107 0.967 rs55835501 chr2:234157733 C/T cg07618928 chr2:234183455 ATG16L1;SCARNA5 0.65 11.02 0.52 2.92e-24 Crohn's disease;Inflammatory bowel disease; CRC cis rs262150 0.659 rs2527237 chr7:158798494 A/G cg19418458 chr7:158789849 NA 0.5 8.73 0.43 1.26e-16 Facial morphology (factor 20); CRC cis rs12594515 1.000 rs58368732 chr15:45990531 G/C cg01629716 chr15:45996671 NA 0.41 8.46 0.42 9.03e-16 Waist circumference;Weight; CRC cis rs3617 0.625 rs11922961 chr3:52868610 T/C cg15147215 chr3:52552868 STAB1 0.52 9.04 0.45 1.36e-17 Red blood cell count;Autism spectrum disorder or schizophrenia; CRC cis rs3764400 0.508 rs2240121 chr17:46152322 T/C cg10706073 chr17:46328419 SKAP1 -0.62 -6.64 -0.34 1.33e-10 Body mass index; CRC cis rs1005224 0.889 rs12717566 chr14:76147507 C/T cg25116370 chr14:76127843 TTLL5;C14orf1 -0.43 -6.67 -0.35 1.09e-10 Large artery stroke; CRC trans rs10403021 0.960 rs10518279 chr19:30085145 C/T cg22044635 chr17:76557109 DNAH17 0.46 6.27 0.33 1.14e-9 Diabetic retinopathy; CRC cis rs6570726 0.935 rs384519 chr6:145846017 C/A cg23711669 chr6:146136114 FBXO30 0.69 12.41 0.56 2.75e-29 Lobe attachment (rater-scored or self-reported); CRC trans rs11654801 0.947 rs11541311 chr17:20911204 G/T cg23759823 chr7:139672531 TBXAS1 -0.47 -6.78 -0.35 5.72e-11 Mosquito bite size; CRC cis rs2692947 0.770 rs4527246 chr2:96560303 T/C cg23100626 chr2:96804247 ASTL 0.27 7.11 0.36 7.24e-12 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; CRC cis rs929354 0.772 rs1002389 chr7:156968323 C/G cg17757837 chr7:157058334 UBE3C 0.72 12.12 0.56 3.35e-28 Body mass index; CRC cis rs4665809 0.531 rs12987980 chr2:26462093 A/T cg27170947 chr2:26402098 FAM59B 0.6 7.82 0.4 7.45e-14 Gut microbiome composition (summer); CRC cis rs3768617 0.510 rs10752895 chr1:183068505 C/G ch.1.3577855R chr1:183094577 LAMC1 0.86 15.1 0.64 1.66e-39 Fuchs's corneal dystrophy; CRC cis rs877282 1.000 rs12219807 chr10:772870 A/C cg17470449 chr10:769945 NA 0.6 8.43 0.42 1.11e-15 Uric acid levels; CRC cis rs34787248 1 rs34787248 chr6:28197886 C/T cg03623178 chr6:28175578 NA 0.79 8.5 0.42 6.74e-16 Autism spectrum disorder or schizophrenia; CRC cis rs172166 0.516 rs1150670 chr6:28130559 A/G cg21251018 chr6:28226885 NKAPL 0.58 10.15 0.49 3.17e-21 Cardiac Troponin-T levels; CRC cis rs11030122 0.547 rs12270732 chr11:3952901 C/A cg18678763 chr11:4115507 RRM1 -0.39 -6.61 -0.34 1.59e-10 Mean platelet volume;Platelet distribution width; CRC cis rs9467711 0.539 rs34436535 chr6:26370365 G/C cg14345882 chr6:26364793 BTN3A2 0.65 5.74 0.3 2.17e-8 Autism spectrum disorder or schizophrenia; CRC cis rs5769765 0.773 rs9616391 chr22:50314573 C/T cg08270630 chr22:50330655 NA -0.43 -5.93 -0.31 7.59e-9 Schizophrenia; CRC cis rs12908161 0.959 rs17534709 chr15:85314397 G/C cg17507749 chr15:85114479 UBE2QP1 0.62 8.6 0.43 3.39e-16 Schizophrenia; CRC cis rs2836974 0.899 rs35774464 chr21:40580169 G/A cg07074390 chr21:40555500 PSMG1 -0.46 -6.22 -0.32 1.54e-9 Cognitive function; CRC cis rs2976388 1.000 rs1045574 chr8:143763958 C/T cg22687807 chr8:143858763 LYNX1 -0.38 -6.64 -0.34 1.28e-10 Urinary tract infection frequency; CRC cis rs1552244 0.572 rs7645759 chr3:10157368 C/T cg08888203 chr3:10149979 C3orf24 0.69 8.16 0.41 6.96e-15 Alzheimer's disease; CRC trans rs9291683 0.620 rs7699512 chr4:10125808 C/T cg26043149 chr18:55253948 FECH -0.58 -8.96 -0.44 2.41e-17 Bone mineral density; CRC cis rs2836974 0.966 rs7283516 chr21:40690537 A/G cg11644478 chr21:40555479 PSMG1 0.74 10.8 0.51 1.73e-23 Cognitive function; CRC cis rs40363 0.645 rs4786421 chr16:3522303 A/G cg21433313 chr16:3507492 NAT15 -0.55 -8.4 -0.42 1.36e-15 Tuberculosis; CRC cis rs28386778 0.863 rs8076760 chr17:61920497 T/C cg23090583 chr17:61904693 PSMC5;FTSJ3 1.05 20.55 0.75 5.84e-61 Prudent dietary pattern; CRC cis rs7666738 0.752 rs62318905 chr4:99036103 T/G cg05340658 chr4:99064831 C4orf37 0.6 9.27 0.46 2.53e-18 Colonoscopy-negative controls vs population controls; CRC cis rs6942756 0.806 rs10248810 chr7:128993806 G/A cg02491457 chr7:128862824 NA -0.63 -8.75 -0.43 1.13e-16 White matter hyperintensity burden; CRC cis rs10744422 0.920 rs10773657 chr12:123327900 C/A cg25930673 chr12:123319894 HIP1R -0.56 -6.12 -0.32 2.66e-9 Schizophrenia; CRC cis rs9807989 0.507 rs6758936 chr2:102991369 A/G cg03938978 chr2:103052716 IL18RAP -0.59 -10.36 -0.5 6e-22 Asthma; CRC cis rs2239547 0.618 rs3733047 chr3:52871929 A/G cg10802521 chr3:52805072 NEK4 0.46 6.12 0.32 2.64e-9 Schizophrenia; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg01530797 chr7:139875863 LOC100134229;JHDM1D 0.47 6.48 0.34 3.33e-10 Response to antipsychotic treatment; CRC trans rs2303319 0.582 rs12464282 chr2:162448855 C/T cg15664909 chr17:685709 GLOD4;RNMTL1 -0.67 -5.96 -0.31 6.48e-9 Cognitive function; CRC cis rs7412746 0.658 rs11204723 chr1:150731618 T/C cg15448220 chr1:150897856 SETDB1 0.54 7.59 0.39 3.39e-13 Melanoma; CRC cis rs713587 0.571 rs475868 chr2:25318059 A/G cg22495460 chr2:25135724 ADCY3 0.39 5.76 0.3 1.89e-8 Body mass index in non-asthmatics; CRC cis rs2249694 1.000 rs4363513 chr10:135355534 A/G cg16964102 chr10:135390573 NA -0.43 -7.04 -0.36 1.11e-11 Obesity-related traits; CRC cis rs2839186 0.900 rs59828751 chr21:47708918 A/G cg09417038 chr21:47716443 C21orf57 -0.42 -6.93 -0.36 2.21e-11 Testicular germ cell tumor; CRC cis rs2836950 0.565 rs2836943 chr21:40592611 C/T cg06238570 chr21:40685208 BRWD1 -0.61 -8.81 -0.44 7.38e-17 Menarche (age at onset); CRC cis rs172166 0.561 rs149973 chr6:27983613 G/T cg06470822 chr6:28175283 NA 0.65 9.68 0.47 1.16e-19 Cardiac Troponin-T levels; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg09920427 chr19:12777674 MORG1;MAN2B1 0.42 6.15 0.32 2.25e-9 Intelligence (multi-trait analysis); CRC cis rs7618915 0.501 rs12635140 chr3:52738165 C/T cg10802521 chr3:52805072 NEK4 0.56 8.7 0.43 1.6e-16 Bipolar disorder; CRC trans rs2797160 0.967 rs1343120 chr6:125992810 A/G cg05039488 chr6:79577232 IRAK1BP1 -0.5 -7.51 -0.38 5.79e-13 Endometrial cancer; CRC cis rs9534288 0.797 rs2404728 chr13:46581862 T/C cg15192986 chr13:46630673 CPB2 -0.67 -9.85 -0.48 3.16e-20 Blood protein levels; CRC cis rs77861329 0.920 rs9860982 chr3:52096432 T/C cg08692210 chr3:52188851 WDR51A 0.88 8.43 0.42 1.1e-15 Macrophage inflammatory protein 1b levels; CRC cis rs1182436 1 rs1182436 chr7:157027753 T/C cg00092383 chr7:157075207 NA 0.23 5.65 0.3 3.43e-8 Type 2 diabetes; CRC cis rs10751667 0.666 rs4074233 chr11:977685 G/A cg01483505 chr11:975446 AP2A2 0.46 7.66 0.39 2.11e-13 Alzheimer's disease (late onset); CRC cis rs6479527 0.875 rs914297 chr9:96816506 T/A cg14459158 chr9:96720562 NA 0.38 6.71 0.35 8.37e-11 Esophageal adenocarcinoma; CRC cis rs6951245 0.638 rs4720486 chr7:1146764 G/A cg04025307 chr7:1156635 C7orf50 0.67 8.42 0.42 1.18e-15 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs7208859 0.673 rs9912122 chr17:29140716 C/A cg01831904 chr17:28903510 LRRC37B2 -0.51 -6.07 -0.32 3.47e-9 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs2252790 0.548 rs114094955 chr6:116521164 G/T cg15226275 chr6:116381976 FRK 0.26 5.78 0.3 1.75e-8 Fast beta electroencephalogram; CRC cis rs8180040 0.966 rs11130129 chr3:47489885 G/C cg10298567 chr3:47292165 KIF9 0.39 6.28 0.33 1.08e-9 Colorectal cancer; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg15118204 chr17:79876231 MAFG;SIRT7 0.42 6.23 0.32 1.43e-9 Intelligence (multi-trait analysis); CRC cis rs2070677 0.935 rs4384343 chr10:135422545 G/C cg16964102 chr10:135390573 NA 0.49 6.77 0.35 5.9e-11 Gout; CRC cis rs35306767 0.903 rs34847097 chr10:902252 A/T cg26597838 chr10:835615 NA 0.88 11.03 0.52 2.73e-24 Eosinophil percentage of granulocytes; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg08306365 chr15:62543301 NA -0.32 -5.97 -0.31 6.08e-9 Liver disease severity in Alagille syndrome; CRC cis rs6977940 0.558 rs11770455 chr7:2888014 G/A cg19731401 chr7:2775893 GNA12 0.6 5.78 0.3 1.78e-8 White matter integrity; CRC cis rs4713118 0.616 rs9348789 chr6:28025486 C/T cg15786705 chr6:28176104 NA 0.69 9.22 0.45 3.64e-18 Parkinson's disease; CRC cis rs2289583 0.500 rs67168917 chr15:75391494 G/T cg17294928 chr15:75287854 SCAMP5 -0.43 -6.38 -0.33 5.99e-10 Systemic lupus erythematosus; CRC cis rs2576037 0.526 rs605487 chr18:44444778 G/C cg24750912 chr18:44543259 TCEB3CL;KATNAL2 0.3 6.02 0.32 4.64e-9 Personality dimensions; CRC cis rs1215050 0.904 rs2903153 chr4:99057457 C/T cg05340658 chr4:99064831 C4orf37 0.44 6.16 0.32 2.11e-9 Waist-to-hip ratio adjusted for body mass index; CRC trans rs208520 0.661 rs1100950 chr6:66827285 A/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.08 -14.89 -0.63 1.12e-38 Exhaled nitric oxide output; CRC trans rs916888 0.647 rs199524 chr17:44848438 G/T cg10053473 chr17:62856997 LRRC37A3 0.66 9.11 0.45 8.34e-18 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs11651000 0.625 rs11079786 chr17:45805916 A/G cg24803719 chr17:45855879 NA 0.29 6.26 0.33 1.2e-9 IgG glycosylation; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg16487852 chr16:83841511 HSBP1 0.47 7.86 0.4 5.62e-14 Liver disease severity in Alagille syndrome; CRC cis rs9393777 0.920 rs34150729 chr6:27388754 T/C cg26958806 chr6:27640298 NA 0.93 6.09 0.32 3.08e-9 Intelligence (multi-trait analysis); CRC cis rs4888262 0.526 rs7191754 chr16:74610850 G/T cg01733217 chr16:74700730 RFWD3 0.78 11.82 0.55 4.24e-27 Testicular germ cell tumor; CRC cis rs4713118 0.629 rs203888 chr6:28021589 C/T cg03623178 chr6:28175578 NA 0.85 12.48 0.57 1.55e-29 Parkinson's disease; CRC cis rs12760731 0.582 rs2147031 chr1:178572474 T/G cg00404053 chr1:178313656 RASAL2 0.65 7.01 0.36 1.36e-11 Obesity-related traits; CRC cis rs7605827 0.930 rs13019216 chr2:15659539 A/G cg19274914 chr2:15703543 NA 0.39 5.89 0.31 9.8e-9 Educational attainment (years of education); CRC cis rs763014 0.966 rs4984675 chr16:670117 T/C cg04562611 chr16:615315 C16orf11 0.36 6.07 0.32 3.6e-9 Height; CRC trans rs9354352 0.784 rs2062327 chr6:66689923 C/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.63 -9.29 -0.46 2.24e-18 Initial pursuit acceleration in psychotic disorders; CRC cis rs4731207 0.698 rs10250202 chr7:124465509 A/C cg23710748 chr7:124431027 NA 0.38 6.08 0.32 3.42e-9 Cutaneous malignant melanoma; CRC cis rs12692738 0.526 rs171392 chr2:165621464 T/C cg03182029 chr2:165697222 COBLL1 0.51 6.09 0.32 3.18e-9 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);Waist-to-hip ratio adjusted for BMI in non-smokers;Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction);Waist-to-hip ratio adjusted for body mass index; CRC cis rs9443645 0.687 rs6915558 chr6:79769056 A/T cg05283184 chr6:79620031 NA -0.61 -9.85 -0.48 3.19e-20 Intelligence (multi-trait analysis); CRC cis rs10991814 0.920 rs61021072 chr9:94038021 T/C cg14446406 chr9:93919335 NA 0.58 6.46 0.34 3.77e-10 Neutrophil percentage of granulocytes; CRC cis rs12701220 0.901 rs12701708 chr7:1090333 C/T cg26769984 chr7:1090371 C7orf50 0.69 9.85 0.48 3.06e-20 Bronchopulmonary dysplasia; CRC cis rs7777484 0.517 rs2644306 chr7:2831602 A/G cg13628971 chr7:2884303 GNA12 0.39 6.07 0.32 3.52e-9 Height; CRC cis rs720844 1.000 rs4972381 chr2:149336554 T/C cg09247360 chr2:149335327 NA -0.61 -7.7 -0.39 1.5700000000000001e-13 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs758324 0.947 rs10052255 chr5:131173106 C/T cg06307176 chr5:131281290 NA 0.43 6.4 0.33 5.5e-10 Alzheimer's disease in APOE e4- carriers; CRC cis rs9807989 0.507 rs7581119 chr2:103049865 G/A cg03938978 chr2:103052716 IL18RAP 0.59 10.1 0.49 4.69e-21 Asthma; CRC cis rs9926296 0.585 rs8045232 chr16:89857548 A/G cg21285383 chr16:89894308 SPIRE2 0.34 5.69 0.3 2.82e-8 Vitiligo; CRC cis rs6691722 0.503 rs2274168 chr1:24707211 G/T cg18323236 chr1:24743029 NIPAL3 0.39 5.71 0.3 2.55e-8 Response to interferon beta in multiple sclerosis; CRC cis rs916888 0.821 rs199504 chr17:44861003 C/T cg15921436 chr17:44337874 NA -0.69 -7.82 -0.4 7.03e-14 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs311392 0.584 rs388075 chr8:55099893 T/C cg06042504 chr8:55087323 NA -0.37 -5.78 -0.3 1.71e-8 Pelvic organ prolapse (moderate/severe); CRC trans rs8064024 0.513 rs1049207 chr16:4934564 C/G cg19252218 chr17:41477271 ARL4D -0.41 -6.16 -0.32 2.08e-9 Cancer; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg16714432 chr6:75994713 TMEM30A 0.41 6.45 0.34 4.11e-10 Liver disease severity in Alagille syndrome; CRC cis rs910187 0.678 rs6018329 chr20:45813184 A/G cg27589058 chr20:45804311 EYA2 -0.39 -7.38 -0.38 1.29e-12 Migraine; CRC cis rs13108904 0.840 rs13106092 chr4:1257290 T/A cg19318889 chr4:1322082 MAEA 0.41 5.91 0.31 8.6e-9 Obesity-related traits; CRC cis rs2243480 1.000 rs316329 chr7:65608416 A/C cg12463550 chr7:65579703 CRCP 0.68 6.5 0.34 2.96e-10 Diabetic kidney disease; CRC cis rs4713118 0.513 rs149950 chr6:28033039 T/G cg15845792 chr6:28175446 NA 0.78 11.57 0.54 3.33e-26 Parkinson's disease; CRC cis rs919433 0.756 rs7575389 chr2:198198489 A/G cg10820045 chr2:198174542 NA -0.47 -8.23 -0.41 4.3e-15 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC cis rs1448094 0.802 rs12369634 chr12:86406792 C/G cg02569458 chr12:86230093 RASSF9 0.41 6.82 0.35 4.31e-11 Major depressive disorder; CRC cis rs6582630 0.576 rs4882372 chr12:38356609 C/A cg26384229 chr12:38710491 ALG10B -0.53 -7.71 -0.39 1.54e-13 Drug-induced liver injury (flucloxacillin); CRC cis rs12451471 0.667 rs12942002 chr17:78101629 C/G cg12100956 chr17:78086420 GAA -0.36 -5.63 -0.3 3.92e-8 Plateletcrit;Mean corpuscular hemoglobin concentration; CRC cis rs9467711 0.516 rs501220 chr6:25873025 C/A cg08501292 chr6:25962987 TRIM38 0.64 7.15 0.37 5.48e-12 Autism spectrum disorder or schizophrenia; CRC cis rs7635838 0.892 rs9838141 chr3:11488639 C/T cg00170343 chr3:11313890 ATG7 0.42 6.37 0.33 6.45e-10 HDL cholesterol; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg27099978 chr3:48673001 SLC26A6 0.42 6.16 0.32 2.14e-9 Intelligence (multi-trait analysis); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg00499509 chr1:149605515 LOC728855 0.42 6.8 0.35 5.05e-11 Liver disease severity in Alagille syndrome; CRC cis rs6831352 0.842 rs1230156 chr4:99989626 C/T cg12011299 chr4:100065546 ADH4 0.51 10.19 0.49 2.3e-21 Alcohol dependence; CRC cis rs2932538 0.583 rs2279500 chr1:113244433 T/C cg22162597 chr1:113214053 CAPZA1 -0.62 -7.3 -0.37 2.19e-12 Systolic blood pressure;Diastolic blood pressure;Hypertension;Blood pressure; CRC cis rs6496667 0.779 rs2238324 chr15:91006989 T/C cg04176472 chr15:90893244 GABARAPL3 0.58 8.02 0.4 1.81e-14 Rheumatoid arthritis; CRC trans rs2727020 0.595 rs10466496 chr11:49501514 C/T cg11707556 chr5:10655725 ANKRD33B -0.4 -7.48 -0.38 7.02e-13 Coronary artery disease; CRC cis rs6952808 0.723 rs60995052 chr7:2030007 G/C cg04267008 chr7:1944627 MAD1L1 -0.78 -11.33 -0.53 2.45e-25 Bipolar disorder and schizophrenia; CRC cis rs7618915 0.547 rs2286800 chr3:52778051 C/T cg18099408 chr3:52552593 STAB1 -0.44 -7.2 -0.37 4.11e-12 Bipolar disorder; CRC cis rs8180040 0.726 rs4682842 chr3:46982773 C/G cg27129171 chr3:47204927 SETD2 -0.74 -11.47 -0.53 7.33e-26 Colorectal cancer; CRC cis rs2635047 0.967 rs2684820 chr18:44664304 G/A cg19077165 chr18:44547161 KATNAL2 -0.45 -7.2 -0.37 4.22e-12 Educational attainment; CRC cis rs7615952 0.576 rs12497295 chr3:125818650 G/A cg05084668 chr3:125655381 ALG1L -0.45 -6.4 -0.33 5.22e-10 Blood pressure (smoking interaction); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg04131734 chr11:102323536 TMEM123 0.47 7.36 0.38 1.44e-12 Liver disease severity in Alagille syndrome; CRC cis rs75920871 0.588 rs7119185 chr11:116886096 C/T cg20608306 chr11:116969690 SIK3 -0.31 -5.78 -0.3 1.76e-8 Subjective well-being; CRC cis rs59918340 0.728 rs4961340 chr8:142232002 G/A cg17298326 chr8:142245477 NA -0.38 -5.78 -0.3 1.78e-8 Immature fraction of reticulocytes; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg20548716 chr17:7531197 SHBG;SAT2 0.45 6.36 0.33 6.75e-10 Response to antipsychotic treatment; CRC cis rs6598955 0.694 rs4659416 chr1:26580937 T/G cg04990556 chr1:26633338 UBXN11 -0.78 -13.44 -0.6 3.88e-33 Obesity-related traits; CRC cis rs9549367 0.789 rs2287253 chr13:113891075 G/A cg24300038 chr13:113819356 PROZ 0.43 5.78 0.3 1.74e-8 Platelet distribution width; CRC cis rs9341808 0.690 rs3805926 chr6:80879280 C/G cg08355045 chr6:80787529 NA 0.44 7.08 0.36 8.93e-12 Sitting height ratio; CRC cis rs394563 0.591 rs237028 chr6:149718650 C/T cg03678062 chr6:149772716 ZC3H12D -0.35 -6.44 -0.33 4.3e-10 Dupuytren's disease; CRC cis rs9311474 1.000 rs2276834 chr3:52325759 A/G cg18099408 chr3:52552593 STAB1 -0.49 -8.34 -0.42 1.99e-15 Electroencephalogram traits; CRC cis rs6961069 0.742 rs1722502 chr7:80241874 A/C cg04458919 chr7:80252533 CD36 -0.36 -6.37 -0.33 6.47e-10 Platelet count; CRC cis rs11190604 1.000 rs4919465 chr10:102221703 C/T cg07570687 chr10:102243282 WNT8B 0.44 5.66 0.3 3.36e-8 Palmitoleic acid (16:1n-7) levels; CRC cis rs812925 0.859 rs2593624 chr2:61552484 T/A cg10580144 chr2:61372316 C2orf74 -0.32 -6.64 -0.34 1.28e-10 Immature fraction of reticulocytes; CRC cis rs929354 0.739 rs12533082 chr7:157014172 T/A cg05182265 chr7:156933206 UBE3C -0.77 -14.67 -0.63 7.87e-38 Body mass index; CRC cis rs4523957 0.928 rs11869805 chr17:2176532 A/G cg16513277 chr17:2031491 SMG6 -0.54 -9.12 -0.45 7.71e-18 Autism spectrum disorder or schizophrenia;Schizophrenia; CRC cis rs12580194 0.593 rs73326725 chr12:55749222 G/C cg23425280 chr12:56401806 NA 0.47 5.72 0.3 2.44e-8 Cancer; CRC cis rs1865760 0.566 rs1971509 chr6:26085777 T/C cg16482183 chr6:26056742 HIST1H1C 0.52 7.58 0.39 3.66e-13 Height; CRC cis rs6502050 0.835 rs8078950 chr17:80122327 T/G cg09264619 chr17:80180166 NA -0.35 -5.93 -0.31 7.47e-9 Life satisfaction; CRC cis rs651907 0.535 rs11711903 chr3:101500748 C/G cg12386194 chr3:101231763 SENP7 0.52 7.63 0.39 2.48e-13 Colorectal cancer; CRC cis rs694739 1.000 rs1783521 chr11:64106291 T/C cg23796481 chr11:64053134 BAD;GPR137 0.56 8.52 0.43 5.64e-16 Alopecia areata;Crohn's disease;Psoriasis vulgaris; CRC cis rs9926296 0.605 rs12709094 chr16:89853017 A/G cg03388025 chr16:89894329 SPIRE2 0.4 7.91 0.4 4.08e-14 Vitiligo; CRC trans rs2303319 0.504 rs62189055 chr2:162625749 C/A cg11326919 chr17:43324904 LOC100133991 -0.65 -6.03 -0.32 4.51e-9 Cognitive function; CRC cis rs12142240 0.667 rs41293287 chr1:46808852 C/T cg00530320 chr1:46809349 NSUN4 0.58 7.98 0.4 2.46e-14 Menopause (age at onset); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg07867325 chr3:73159953 NA -0.42 -6.57 -0.34 1.95e-10 Liver disease severity in Alagille syndrome; CRC cis rs10191773 0.589 rs72833410 chr2:113054119 G/A cg24977338 chr2:113188963 RGPD8;RGPD5 -0.62 -5.83 -0.31 1.33e-8 Yeast infection; CRC cis rs231513 0.954 rs170766 chr17:41963407 C/G cg26893861 chr17:41843967 DUSP3 -0.65 -6.62 -0.34 1.42e-10 Cognitive function; CRC cis rs9303401 0.527 rs7224468 chr17:56749943 C/T cg02118635 chr17:56770003 RAD51C;TEX14 0.75 9.02 0.45 1.56e-17 Cognitive test performance; CRC cis rs2274471 0.645 rs3824432 chr9:5091675 G/A cg03390472 chr9:5043263 JAK2 -0.59 -7.03 -0.36 1.17e-11 Crohn's disease; CRC trans rs561341 0.769 rs7217004 chr17:30178092 A/G cg20587970 chr11:113659929 NA 1.05 11.85 0.55 3.18e-27 Hip circumference adjusted for BMI; CRC cis rs6952808 1.000 rs6978048 chr7:1886872 T/G cg02951883 chr7:2050386 MAD1L1 -0.72 -11.39 -0.53 1.52e-25 Bipolar disorder and schizophrenia; CRC cis rs9814567 0.929 rs1863912 chr3:134205227 C/T cg06109529 chr3:134205091 CEP63;ANAPC13 -0.8 -12.39 -0.56 3.47e-29 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs9733 0.519 rs1336899 chr1:150678910 T/C cg15448220 chr1:150897856 SETDB1 0.47 6.72 0.35 7.83e-11 Tonsillectomy; CRC cis rs6496667 0.683 rs2589973 chr15:90892293 C/T cg00425431 chr15:90792223 TTLL13 0.32 5.65 0.3 3.54e-8 Rheumatoid arthritis; CRC cis rs400736 0.562 rs12129505 chr1:8171734 T/C cg25007680 chr1:8021821 PARK7 -0.52 -6.87 -0.35 3.21e-11 Response to antidepressants and depression; CRC cis rs79349575 0.715 rs55724082 chr17:47017879 G/A cg22482690 chr17:47019901 SNF8 0.48 8.01 0.4 1.99e-14 Type 2 diabetes; CRC cis rs950169 0.614 rs12903883 chr15:84680553 A/G cg11189052 chr15:85197271 WDR73 0.54 7.2 0.37 4.12e-12 Schizophrenia; CRC cis rs77633900 0.614 rs280013 chr15:76978139 C/T cg21673338 chr15:77095150 SCAPER 0.72 7.19 0.37 4.45e-12 Non-glioblastoma glioma;Glioma; CRC cis rs9911578 0.967 rs7503190 chr17:57184162 A/C cg05425664 chr17:57184151 TRIM37 -0.52 -8.3 -0.42 2.73e-15 Intelligence (multi-trait analysis); CRC cis rs13191362 0.935 rs34063386 chr6:163041271 T/C cg14584255 chr6:163149320 PACRG;PARK2 0.43 6.03 0.32 4.51e-9 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs11650494 0.908 rs57390430 chr17:47374886 G/A cg08112188 chr17:47440006 ZNF652 1.13 10.47 0.5 2.49e-22 Prostate cancer; CRC cis rs11758351 0.660 rs55848726 chr6:26224434 T/C cg01420254 chr6:26195488 NA 0.77 8.59 0.43 3.61e-16 Gout;Renal underexcretion gout; CRC trans rs7615952 0.741 rs13314845 chr3:125644782 C/T cg16558177 chr4:4109446 NA -0.48 -6.22 -0.32 1.48e-9 Blood pressure (smoking interaction); CRC cis rs801193 0.548 rs2109297 chr7:66122384 G/A cg11764359 chr7:65958608 NA -0.59 -8.69 -0.43 1.7e-16 Aortic root size; CRC cis rs1862618 0.671 rs2591968 chr5:56233541 A/G cg18230493 chr5:56204884 C5orf35 -0.6 -8.63 -0.43 2.68e-16 Initial pursuit acceleration; CRC cis rs13108904 0.967 rs1732107 chr4:1276758 G/A cg20887711 chr4:1340912 KIAA1530 -0.44 -6.4 -0.33 5.31e-10 Obesity-related traits; CRC cis rs9911578 0.785 rs10853008 chr17:56993407 T/C cg12560992 chr17:57184187 TRIM37 -0.86 -13.21 -0.59 2.97e-32 Intelligence (multi-trait analysis); CRC cis rs9311474 0.508 rs6788887 chr3:52605005 T/C cg05573699 chr3:52720067 GNL3;PBRM1 -0.44 -6.45 -0.34 3.94e-10 Electroencephalogram traits; CRC cis rs11195062 0.521 rs4918485 chr10:111949323 A/T cg00817464 chr10:111662876 XPNPEP1 0.38 5.85 0.31 1.19e-8 Multiple myeloma; CRC cis rs9868809 0.772 rs73078349 chr3:48688114 G/A cg00383909 chr3:49044727 WDR6 1.3 10.52 0.5 1.69e-22 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; CRC cis rs668210 0.793 rs1151514 chr11:65758854 G/A cg02202077 chr11:65769826 EIF1AD;BANF1 0.48 6.48 0.34 3.37e-10 Cerebrospinal fluid biomarker levels; CRC cis rs7726839 0.540 rs12517638 chr5:645484 C/T cg16447950 chr5:562315 NA -0.77 -10.22 -0.49 1.75e-21 Obesity-related traits; CRC cis rs875971 0.895 rs12531677 chr7:65769086 G/A cg18252515 chr7:66147081 NA 0.41 5.73 0.3 2.26e-8 Aortic root size; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg05183487 chr16:89992959 TUBB3 0.44 6.74 0.35 6.96e-11 Liver disease severity in Alagille syndrome; CRC cis rs9291683 0.655 rs3822242 chr4:10094904 T/C cg11266682 chr4:10021025 SLC2A9 -0.45 -9.1 -0.45 9.04e-18 Bone mineral density; CRC cis rs3790844 0.515 rs35094784 chr1:199949274 T/C cg13229857 chr1:200006247 NR5A2 0.51 7.36 0.38 1.44e-12 Pancreatic cancer; CRC cis rs3741151 1.000 rs112840535 chr11:73066771 G/A cg17517138 chr11:73019481 ARHGEF17 1.12 9.65 0.47 1.47e-19 GIP levels in response to oral glucose tolerance test (120 minutes); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg21137026 chr11:417246 SIGIRR 0.43 6.02 0.31 4.7e-9 Response to antipsychotic treatment; CRC cis rs4478858 0.735 rs34960310 chr1:31816197 A/G cg00250761 chr1:31883323 NA -0.44 -8.5 -0.42 6.71e-16 Alcohol dependence; CRC cis rs12477438 0.798 rs2045057 chr2:99684929 A/G cg26064155 chr2:99771622 LIPT1;TSGA10 -0.79 -11.26 -0.53 4.44e-25 Chronic sinus infection; CRC cis rs9811920 0.609 rs4244711 chr3:99657205 A/G cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G -0.46 -6.18 -0.32 1.87e-9 Axial length; CRC cis rs3741151 1.000 rs74346863 chr11:73054772 C/T cg17517138 chr11:73019481 ARHGEF17 1.07 9.18 0.45 5.01e-18 GIP levels in response to oral glucose tolerance test (120 minutes); CRC cis rs908922 0.676 rs10788842 chr1:152514588 A/T cg23254163 chr1:152506842 NA 0.44 8.62 0.43 2.8e-16 Hair morphology; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg23318986 chr2:149895139 LYPD6B 0.41 6.81 0.35 4.52e-11 Liver disease severity in Alagille syndrome; CRC cis rs2760061 0.626 rs635563 chr1:228136834 C/T cg18477163 chr1:228402036 OBSCN -0.38 -6.17 -0.32 1.95e-9 Diastolic blood pressure; CRC cis rs10089 1.000 rs7703634 chr5:127509223 A/C cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.67 8.96 0.44 2.45e-17 Ileal carcinoids; CRC cis rs1124376 0.935 rs28716666 chr3:20148409 C/T cg05072819 chr3:20081367 KAT2B 0.49 5.85 0.31 1.21e-8 Bipolar disorder and schizophrenia; CRC cis rs12024301 0.557 rs12045319 chr1:183608449 A/G cg11505048 chr1:183622726 RGL1;APOBEC4 0.81 6.83 0.35 4.19e-11 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs317689 0.608 rs650198 chr12:69674595 C/T cg14784868 chr12:69753453 YEATS4 0.45 5.83 0.31 1.29e-8 Response to diuretic therapy; CRC cis rs8099014 0.861 rs4940703 chr18:56115386 A/G cg12907477 chr18:56117327 MIR122 0.46 5.96 0.31 6.58e-9 Platelet count; CRC trans rs10802346 0.545 rs10924545 chr1:246364592 C/T cg13514129 chr1:39547527 MACF1 -0.66 -10.21 -0.49 1.97e-21 Fractional exhaled nitric oxide (childhood); CRC cis rs877282 1.000 rs112522746 chr10:772288 T/C cg06581033 chr10:766294 NA -0.47 -5.71 -0.3 2.58e-8 Uric acid levels; CRC cis rs67311347 0.713 rs114569261 chr3:40314580 G/A cg09455208 chr3:40491958 NA 0.33 6.56 0.34 2.06e-10 Renal cell carcinoma; CRC cis rs523522 0.962 rs2393590 chr12:120913900 G/A cg27279351 chr12:120934652 DYNLL1 0.79 11.62 0.54 2.26e-26 High light scatter reticulocyte count; CRC cis rs9992667 0.955 rs2078179 chr4:38664499 A/G cg19726192 chr4:38663646 FLJ13197 -0.71 -9.02 -0.45 1.62e-17 Eosinophil percentage of granulocytes; CRC cis rs853679 0.760 rs9357067 chr6:28210293 C/G cg15786705 chr6:28176104 NA 0.62 6.67 0.34 1.11e-10 Depression; CRC cis rs1941023 0.584 rs950803 chr11:60152563 A/T cg08716584 chr11:60157161 MS4A7 0.51 8.62 0.43 2.89e-16 Congenital heart disease (maternal effect); CRC cis rs13108904 0.517 rs13128825 chr4:1334007 G/A cg23123621 chr4:1343375 KIAA1530 0.35 5.62 0.3 4.09e-8 Obesity-related traits; CRC cis rs216303 0.841 rs2239160 chr12:6162754 A/G cg19878637 chr12:6148451 VWF -0.47 -5.9 -0.31 9.21e-9 Low vWF levels; CRC cis rs7917772 0.636 rs10786708 chr10:104526245 C/T cg11453585 chr10:104263688 ACTR1A;SUFU 0.71 10.53 0.5 1.51e-22 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC cis rs7666738 0.830 rs13138063 chr4:99050438 A/C cg17366294 chr4:99064904 C4orf37 0.46 7.78 0.39 9.74e-14 Colonoscopy-negative controls vs population controls; CRC cis rs561341 0.883 rs886224 chr17:30229902 T/C cg00745463 chr17:30367425 LRRC37B -0.74 -8.2 -0.41 5.41e-15 Hip circumference adjusted for BMI; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg06222638 chr17:4542859 ALOX15 0.41 6.58 0.34 1.89e-10 Liver disease severity in Alagille syndrome; CRC cis rs10876993 0.890 rs2640630 chr12:58067267 T/C cg15848620 chr12:58087721 OS9 -0.63 -8.69 -0.43 1.73e-16 Celiac disease or Rheumatoid arthritis; CRC cis rs7412746 0.658 rs12068264 chr1:150727329 C/T cg18016565 chr1:150552671 MCL1 0.42 5.83 0.31 1.36e-8 Melanoma; CRC cis rs477692 0.905 rs7905466 chr10:131438937 A/T cg05714579 chr10:131428358 MGMT -0.56 -8.13 -0.41 8.82e-15 Response to temozolomide; CRC cis rs7659604 0.539 rs56159666 chr4:122782879 G/A cg20573242 chr4:122745356 CCNA2 0.56 8.36 0.42 1.76e-15 Type 2 diabetes; CRC cis rs1129187 0.967 rs9462857 chr6:42943098 T/C cg09436375 chr6:42928200 GNMT -0.32 -5.79 -0.3 1.63e-8 Alzheimer's disease in APOE e4+ carriers; CRC cis rs698833 0.886 rs786654 chr2:44581007 A/G cg04920474 chr2:44395004 PPM1B 0.41 6.16 0.32 2.09e-9 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; CRC cis rs1401999 1.000 rs7620350 chr3:183710053 A/T cg01324343 chr3:183735012 ABCC5 0.8 14.55 0.63 2.16e-37 Anterior chamber depth; CRC cis rs6479527 0.875 rs10117457 chr9:96823684 A/G cg14459158 chr9:96720562 NA 0.37 6.69 0.35 9.7e-11 Esophageal adenocarcinoma; CRC cis rs1790761 0.967 rs1628442 chr11:67238632 C/T cg17375396 chr11:67202808 RPS6KB2 0.33 5.65 0.3 3.43e-8 Mean corpuscular volume; CRC cis rs6570726 0.791 rs11759979 chr6:145918881 C/T cg05347473 chr6:146136440 FBXO30 0.4 6.01 0.31 5.05e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs2011503 1.000 rs11669558 chr19:19655670 C/T cg11584989 chr19:19387371 SF4 0.55 5.89 0.31 9.59e-9 Bipolar disorder; CRC cis rs1008375 0.800 rs28754811 chr4:17612312 C/T cg16339924 chr4:17578868 LAP3 0.49 6.44 0.33 4.14e-10 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs6754459 0.603 rs11894441 chr2:3701972 A/G cg25251562 chr2:3704773 ALLC 0.49 7.31 0.37 1.98e-12 Response to inhaled corticosteroid treatment in asthma (change in FEV1); CRC cis rs2839186 0.616 rs4819213 chr21:47619300 G/A cg26721908 chr21:47610096 LSS 0.45 7.39 0.38 1.21e-12 Testicular germ cell tumor; CRC cis rs9467711 0.606 rs9379863 chr6:26372427 A/G cg16898833 chr6:26189333 HIST1H4D 0.76 6.58 0.34 1.84e-10 Autism spectrum disorder or schizophrenia; CRC trans rs12714314 0.560 rs11694545 chr2:1939208 C/T cg05720666 chr2:69969591 ANXA4 0.45 6.06 0.32 3.75e-9 Type 2 diabetes (age of onset); CRC cis rs9534288 0.797 rs9534287 chr13:46603926 A/C cg15192986 chr13:46630673 CPB2 -0.68 -9.89 -0.48 2.31e-20 Blood protein levels; CRC cis rs1008375 0.932 rs3846356 chr4:17614176 C/T cg16339924 chr4:17578868 LAP3 0.49 6.38 0.33 5.98e-10 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs7552404 0.731 rs10873787 chr1:76367797 G/A cg22875332 chr1:76189707 ACADM 0.63 7.67 0.39 2e-13 Blood metabolite levels;Acylcarnitine levels; CRC cis rs6580649 0.943 rs3803183 chr12:48398080 T/A cg05342945 chr12:48394962 COL2A1 -0.47 -6.59 -0.34 1.76e-10 Lung cancer; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg18004316 chr2:208634121 FZD5 0.36 6.04 0.32 4.16e-9 Liver disease severity in Alagille syndrome; CRC cis rs6502050 0.835 rs8077926 chr17:80117315 C/A cg19223190 chr17:80058835 NA 0.39 6.25 0.33 1.27e-9 Life satisfaction; CRC cis rs6500602 0.701 rs8129 chr16:4562351 A/G cg08645402 chr16:4508243 NA 0.6 9.46 0.46 5.94e-19 Schizophrenia; CRC cis rs2180341 1.000 rs9398837 chr6:127635217 G/A cg27446573 chr6:127587934 RNF146 0.98 14.44 0.62 6.21e-37 Breast cancer; CRC cis rs832540 0.864 rs252908 chr5:56120686 T/C cg12311346 chr5:56204834 C5orf35 -0.46 -6.99 -0.36 1.55e-11 Coronary artery disease; CRC cis rs10992471 0.630 rs10992322 chr9:95159196 A/G cg14631576 chr9:95140430 CENPP -0.31 -5.88 -0.31 1e-8 Visceral adipose tissue/subcutaneous adipose tissue ratio; CRC cis rs2408955 0.522 rs4760679 chr12:48461635 G/T cg15465823 chr12:48382534 COL2A1 -0.38 -6.32 -0.33 8.29e-10 Glycated hemoglobin levels; CRC cis rs9325144 0.647 rs4616077 chr12:39092364 T/C cg26384229 chr12:38710491 ALG10B -0.52 -7.34 -0.37 1.74e-12 Morning vs. evening chronotype; CRC cis rs45509595 0.841 rs401754 chr6:27782538 T/A cg26587870 chr6:27730563 NA -0.6 -5.98 -0.31 5.78e-9 Breast cancer; CRC cis rs7662987 0.517 rs1154405 chr4:100008750 G/A cg13256891 chr4:100009986 ADH5 0.62 8.33 0.42 2.27e-15 Smoking initiation; CRC cis rs6500395 1.000 rs8044519 chr16:48669081 G/T cg04672837 chr16:48644449 N4BP1 0.46 6.79 0.35 5.11e-11 Response to tocilizumab in rheumatoid arthritis; CRC cis rs7524258 0.835 rs75096060 chr1:7270248 G/C cg07173049 chr1:7289937 CAMTA1 0.53 8.71 0.43 1.53e-16 Tourette's syndrome or obsessive-compulsive disorder; CRC cis rs2120019 1.000 rs7175720 chr15:75348962 C/G cg11632617 chr15:75315747 PPCDC 0.51 6.8 0.35 4.91e-11 Blood trace element (Zn levels); CRC cis rs6662572 0.703 rs4364819 chr1:46358510 G/A cg03123370 chr1:45965343 CCDC163P;MMACHC -0.46 -5.85 -0.31 1.16e-8 Blood protein levels; CRC cis rs11764590 0.715 rs62444907 chr7:2083267 C/T cg23422044 chr7:1970798 MAD1L1 -0.54 -6.31 -0.33 9.22e-10 Neuroticism; CRC cis rs8062405 1.000 rs56404918 chr16:28846840 T/G cg16576597 chr16:28551801 NUPR1 0.48 6.9 0.36 2.65e-11 Cognitive ability (multi-trait analysis);Cognitive ability; CRC trans rs2303319 0.504 rs2194732 chr2:162289156 G/A cg04145477 chr6:107077629 RTN4IP1;QRSL1 -0.86 -6.37 -0.33 6.37e-10 Cognitive function; CRC cis rs501916 1.000 rs501916 chr15:48053229 C/A cg16110827 chr15:48056943 SEMA6D -0.36 -6.0 -0.31 5.08e-9 Inflammatory bowel disease;Ulcerative colitis; CRC cis rs1178968 0.901 rs4999954 chr7:72755520 A/G cg25889504 chr7:72793014 NA 0.52 6.18 0.32 1.88e-9 Triglyceride levels; CRC cis rs2204008 0.754 rs11514074 chr12:38401128 C/T cg13010199 chr12:38710504 ALG10B 0.45 5.72 0.3 2.42e-8 Bladder cancer; CRC cis rs11190604 1.000 rs10883511 chr10:102299407 A/G cg07080220 chr10:102295463 HIF1AN 0.49 5.97 0.31 5.99e-9 Palmitoleic acid (16:1n-7) levels; CRC cis rs6951245 0.554 rs35126802 chr7:1134842 C/T cg07217954 chr7:1067459 C7orf50 0.47 5.62 0.3 3.99e-8 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs9814567 1.000 rs6785027 chr3:134211649 A/G cg06541857 chr3:134203789 ANAPC13;CEP63 0.41 6.25 0.33 1.31e-9 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs2346160 0.899 rs1736585 chr6:167688325 G/A cg27333441 chr6:167680455 NA -0.39 -6.36 -0.33 6.59e-10 Parental extreme longevity (95 years and older); CRC cis rs58688157 0.705 rs12803132 chr11:586696 A/G cg14433983 chr11:636460 DRD4 -0.45 -5.71 -0.3 2.54e-8 Systemic lupus erythematosus; CRC cis rs6141769 0.518 rs28510728 chr20:31287891 G/A cg13636640 chr20:31349939 DNMT3B -0.4 -6.01 -0.31 4.9e-9 Subjective well-being; CRC cis rs11098499 0.954 rs7436506 chr4:120393769 T/C cg09307838 chr4:120376055 NA 0.71 11.09 0.52 1.73e-24 Corneal astigmatism; CRC cis rs2180341 0.574 rs13192350 chr6:127677762 G/T cg27446573 chr6:127587934 RNF146 0.6 8.71 0.43 1.5e-16 Breast cancer; CRC cis rs875971 0.964 rs778721 chr7:65845397 C/G cg12463550 chr7:65579703 CRCP 0.48 6.96 0.36 1.89e-11 Aortic root size; CRC cis rs12545109 0.800 rs1467124 chr8:57418862 T/G cg09654669 chr8:57350985 NA -0.45 -7.22 -0.37 3.69e-12 Obesity-related traits; CRC cis rs72634258 0.945 rs35675666 chr1:8021973 G/T cg26816564 chr1:7831052 VAMP3 0.48 5.74 0.3 2.12e-8 Inflammatory bowel disease; CRC cis rs9894429 1.000 rs3935543 chr17:79579874 T/C cg13777783 chr17:79615861 NA -0.3 -5.72 -0.3 2.44e-8 Eye color traits; CRC cis rs9837602 0.529 rs793494 chr3:99508768 T/C cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G -0.49 -6.58 -0.34 1.87e-10 Breast cancer; CRC cis rs10504229 0.728 rs78765835 chr8:58154337 A/G cg08219700 chr8:58056026 NA 0.45 5.74 0.3 2.11e-8 Developmental language disorder (linguistic errors); CRC cis rs910316 1.000 rs9805979 chr14:75566209 G/A cg11812906 chr14:75593930 NEK9 0.61 9.64 0.47 1.5700000000000001e-19 Height; CRC cis rs9747201 0.862 rs11651738 chr17:80178691 A/T cg09264619 chr17:80180166 NA -0.49 -6.86 -0.35 3.45e-11 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs28386778 0.830 rs67905415 chr17:61841236 G/A cg07362569 chr17:61921086 SMARCD2 0.37 5.76 0.3 1.89e-8 Prudent dietary pattern; CRC trans rs79976124 0.837 rs11751994 chr6:66644028 A/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.76 9.55 0.47 3.03e-19 Type 2 diabetes; CRC cis rs644799 0.965 rs573758 chr11:95539591 G/T cg25478527 chr11:95522999 CEP57;FAM76B 0.51 7.69 0.39 1.68e-13 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs2839186 0.500 rs13052701 chr21:47660045 A/T cg00815214 chr21:47717953 NA -0.44 -7.48 -0.38 7.05e-13 Testicular germ cell tumor; CRC cis rs2477686 0.526 rs1998759 chr1:2397174 C/T cg13556452 chr1:2391241 NA -0.37 -6.25 -0.33 1.27e-9 Non-obstructive azoospermia; CRC cis rs1799949 0.929 rs799906 chr17:41278116 T/C cg19454999 chr17:41278357 BRCA1;NBR2 0.4 6.16 0.32 2.1e-9 Menopause (age at onset); CRC cis rs8180040 0.726 rs2061197 chr3:47001350 C/T cg27129171 chr3:47204927 SETD2 -0.72 -11.22 -0.53 5.86e-25 Colorectal cancer; CRC cis rs4821897 0.514 rs739141 chr22:39824450 A/G cg24399712 chr22:39784796 NA 0.45 8.99 0.44 1.98e-17 IgG glycosylation; CRC trans rs561341 0.941 rs4525554 chr17:30312819 T/C cg27661571 chr11:113659931 NA -0.95 -11.14 -0.52 1.11e-24 Hip circumference adjusted for BMI; CRC cis rs9325144 0.624 rs7309400 chr12:39150369 G/C cg26384229 chr12:38710491 ALG10B -0.48 -6.64 -0.34 1.32e-10 Morning vs. evening chronotype; CRC cis rs709400 0.663 rs72708893 chr14:103929535 G/A cg12935359 chr14:103987150 CKB -0.51 -7.87 -0.4 5.11e-14 Body mass index; CRC cis rs1728785 0.818 rs1170430 chr16:68604954 T/C cg02972257 chr16:68554789 NA -0.6 -7.52 -0.38 5.1e-13 Ulcerative colitis; CRC cis rs9359856 0.564 rs72913976 chr6:90390233 T/C cg13799429 chr6:90582589 CASP8AP2 -0.72 -7.7 -0.39 1.61e-13 Bipolar disorder; CRC cis rs1005277 0.579 rs1548255 chr10:38417193 T/C cg17219203 chr10:38645113 HSD17B7P2 -0.4 -5.66 -0.3 3.24e-8 Extrinsic epigenetic age acceleration; CRC cis rs10504229 0.595 rs79077737 chr8:58117520 G/A cg02725872 chr8:58115012 NA -0.65 -11.41 -0.53 1.25e-25 Developmental language disorder (linguistic errors); CRC cis rs7586879 0.639 rs6749170 chr2:25110962 A/G cg04586622 chr2:25135609 ADCY3 -0.53 -9.7 -0.47 1.01e-19 Body mass index; CRC cis rs2952156 0.920 rs2247862 chr17:37829129 A/G cg20243544 chr17:37824526 PNMT 0.56 8.76 0.43 1.05e-16 Asthma; CRC cis rs1707322 0.721 rs11211158 chr1:46132850 C/G cg06784218 chr1:46089804 CCDC17 0.66 12.35 0.56 4.77e-29 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs1801251 1.000 rs71421663 chr2:233619131 A/G cg25237894 chr2:233734115 C2orf82 0.54 8.8 0.44 7.77e-17 Coronary artery disease; CRC cis rs7937682 0.564 rs9633937 chr11:111372799 C/T cg09085632 chr11:111637200 PPP2R1B 0.49 6.53 0.34 2.51e-10 Primary sclerosing cholangitis; CRC cis rs4930103 0.904 rs2067051 chr11:2018168 C/T cg23202291 chr11:1979235 NA 0.47 6.38 0.33 6.11e-10 DNA methylation (parent-of-origin);DNA methylation (variation); CRC cis rs2816062 0.786 rs2745320 chr1:18893592 G/A cg18795169 chr1:18902165 NA -0.92 -19.28 -0.73 5.98e-56 Urate levels in lean individuals; CRC cis rs10071761 0.513 rs10941504 chr5:40367355 G/A cg09067459 chr5:40385259 NA -0.53 -7.11 -0.37 7.18e-12 Selective IgA deficiency; CRC cis rs9814567 1.000 rs6439487 chr3:134260860 G/A cg06541857 chr3:134203789 ANAPC13;CEP63 -0.4 -6.12 -0.32 2.65e-9 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs1129187 0.935 rs9986447 chr6:42942779 C/T cg05552183 chr6:42928497 GNMT -0.62 -9.54 -0.47 3.24e-19 Alzheimer's disease in APOE e4+ carriers; CRC cis rs6088580 0.713 rs1884669 chr20:33171287 G/A cg08999081 chr20:33150536 PIGU 0.64 12.25 0.56 1.07e-28 Glomerular filtration rate (creatinine); CRC cis rs801193 1.000 rs7782320 chr7:66177098 C/T cg00343986 chr7:65444356 GUSB 0.49 7.23 0.37 3.35e-12 Aortic root size; CRC cis rs11031096 0.782 rs2165728 chr11:4147004 T/C cg18678763 chr11:4115507 RRM1 -0.45 -7.75 -0.39 1.13e-13 Mean corpuscular volume;Mean corpuscular hemoglobin; CRC cis rs9916302 0.706 rs4795375 chr17:37662932 T/C cg07936489 chr17:37558343 FBXL20 -0.93 -11.91 -0.55 1.88e-27 Glomerular filtration rate (creatinine); CRC cis rs6952808 0.689 rs4719391 chr7:2048136 T/C cg21782813 chr7:2030301 MAD1L1 0.53 9.37 0.46 1.18e-18 Bipolar disorder and schizophrenia; CRC cis rs2032447 0.933 rs4401650 chr6:26035208 G/A cg12588279 chr6:26043732 HIST1H2BB 0.47 6.87 0.35 3.21e-11 Intelligence (multi-trait analysis); CRC cis rs73411413 0.661 rs11599981 chr11:1520063 C/T cg20027784 chr11:1520631 HCCA2 -0.42 -5.62 -0.3 3.98e-8 Myringotomy; CRC cis rs11025559 0.773 rs16906274 chr11:20470142 T/C cg19653624 chr11:20408972 PRMT3 -0.66 -8.22 -0.41 4.61e-15 Pursuit maintenance gain; CRC cis rs1862618 0.853 rs2113079 chr5:56157951 A/G cg03609598 chr5:56110824 MAP3K1 -0.84 -10.41 -0.5 4.07e-22 Initial pursuit acceleration; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg24474701 chr18:55289098 NARS 0.43 6.32 0.33 8.61e-10 Anxiety disorder; CRC cis rs1044826 0.597 rs6772199 chr3:139178133 C/T cg00490450 chr3:139108681 COPB2 0.45 6.65 0.34 1.19e-10 Obesity-related traits; CRC cis rs9733 0.650 rs3738485 chr1:150552392 C/G cg18016565 chr1:150552671 MCL1 -0.47 -7.0 -0.36 1.4e-11 Tonsillectomy; CRC cis rs734999 0.549 rs6667564 chr1:2520302 T/C cg18854424 chr1:2615690 NA 0.48 9.43 0.46 7.65e-19 Ulcerative colitis; CRC cis rs9611565 0.649 rs202657 chr22:41844786 G/T cg06634786 chr22:41940651 POLR3H 0.69 7.95 0.4 3.04e-14 Vitiligo; CRC cis rs73206853 0.563 rs17682444 chr12:111154626 C/T cg12870014 chr12:110450643 ANKRD13A 0.66 6.66 0.34 1.15e-10 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC cis rs6570726 0.875 rs12524077 chr6:145866333 G/C cg23711669 chr6:146136114 FBXO30 0.71 12.57 0.57 7.49e-30 Lobe attachment (rater-scored or self-reported); CRC cis rs755249 0.567 rs16826038 chr1:39758634 G/A cg18385671 chr1:39797026 MACF1 -0.42 -5.98 -0.31 5.94e-9 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs644799 1.000 rs593665 chr11:95574302 A/G cg03916912 chr11:95522834 CEP57;FAM76B 0.96 18.48 0.71 8.6e-53 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs2032447 0.869 rs2230655 chr6:26033506 A/G cg03264133 chr6:25882463 NA 0.5 6.84 0.35 3.95e-11 Intelligence (multi-trait analysis); CRC cis rs1670533 0.932 rs11731289 chr4:1057773 T/G cg27284194 chr4:1044797 NA 0.5 6.2 0.32 1.66e-9 Recombination rate (females); CRC trans rs1814175 0.645 rs28436748 chr11:50046422 G/A cg11707556 chr5:10655725 ANKRD33B -0.5 -9.83 -0.48 3.72e-20 Height; CRC cis rs1670533 1.000 rs6857085 chr4:1095920 C/A cg27284194 chr4:1044797 NA -0.51 -6.33 -0.33 7.95e-10 Recombination rate (females); CRC trans rs9291683 0.507 rs6827754 chr4:10018153 A/C cg26043149 chr18:55253948 FECH -0.48 -7.18 -0.37 4.7e-12 Bone mineral density; CRC cis rs1218582 0.510 rs2878411 chr1:154823545 C/T cg24250549 chr1:154909240 PMVK 0.44 6.38 0.33 6.05e-10 Prostate cancer; CRC cis rs9341808 0.718 rs9343978 chr6:80971978 A/G cg08355045 chr6:80787529 NA 0.39 6.4 0.33 5.36e-10 Sitting height ratio; CRC cis rs6076065 0.723 rs6137940 chr20:23397491 G/C cg11657817 chr20:23433608 CST11 0.43 6.33 0.33 8.11e-10 Facial morphology (factor 15, philtrum width); CRC cis rs4478858 0.698 rs7543348 chr1:31804805 A/C cg00250761 chr1:31883323 NA -0.44 -8.5 -0.42 6.71e-16 Alcohol dependence; CRC cis rs9341808 0.667 rs2476826 chr6:80876064 C/T cg08355045 chr6:80787529 NA 0.38 6.45 0.34 3.89e-10 Sitting height ratio; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg04464559 chr6:107780641 PDSS2 0.45 6.43 0.33 4.4e-10 Intelligence (multi-trait analysis); CRC cis rs3768617 0.510 rs2027078 chr1:183073478 G/A ch.1.3577855R chr1:183094577 LAMC1 0.89 15.72 0.65 6.5e-42 Fuchs's corneal dystrophy; CRC cis rs10493773 0.609 rs2389972 chr1:86190666 A/G cg23216685 chr1:86174607 ZNHIT6 -0.28 -6.82 -0.35 4.43e-11 Urate levels in overweight individuals; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg07850863 chr19:508078 C19orf20 0.5 7.14 0.37 6.18e-12 Response to antipsychotic treatment; CRC cis rs6686643 0.762 rs9333432 chr1:165611159 A/G cg19407955 chr1:165599744 MGST3 -0.52 -6.62 -0.34 1.49e-10 Total ventricular volume; CRC cis rs7666738 0.819 rs13139560 chr4:99081188 C/T cg17366294 chr4:99064904 C4orf37 0.41 5.69 0.3 2.88e-8 Colonoscopy-negative controls vs population controls; CRC cis rs2739330 0.791 rs4822458 chr22:24265659 C/T cg15242686 chr22:24348715 GSTTP1 0.43 6.65 0.34 1.23e-10 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs6502050 0.835 rs9646397 chr17:80083534 G/A cg25804541 chr17:80189381 SLC16A3 0.31 5.9 0.31 8.94e-9 Life satisfaction; CRC cis rs4713118 0.696 rs2394002 chr6:27748015 G/A cg19041857 chr6:27730383 NA -0.44 -5.93 -0.31 7.49e-9 Parkinson's disease; CRC cis rs1129187 0.755 rs9471982 chr6:42935998 G/A cg00597713 chr6:42947103 PEX6 -0.43 -6.05 -0.32 3.9e-9 Alzheimer's disease in APOE e4+ carriers; CRC cis rs9649213 0.593 rs7803372 chr7:97992257 A/G cg24562669 chr7:97807699 LMTK2 0.42 7.0 0.36 1.45e-11 Prostate cancer (SNP x SNP interaction); CRC cis rs950027 0.620 rs1145089 chr15:45652054 G/C cg21132104 chr15:45694354 SPATA5L1 0.41 5.96 0.31 6.54e-9 Response to fenofibrate (adiponectin levels); CRC cis rs9633740 1.000 rs6586028 chr10:82253984 C/T cg00277334 chr10:82204260 NA -0.56 -6.12 -0.32 2.66e-9 Post bronchodilator FEV1; CRC cis rs9925964 0.933 rs9929899 chr16:31062701 C/A cg02466173 chr16:30829666 NA 0.41 5.65 0.3 3.53e-8 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs910187 0.571 rs6124958 chr20:45801117 T/C cg27589058 chr20:45804311 EYA2 -0.4 -7.67 -0.39 2e-13 Migraine; CRC cis rs6754311 0.731 rs3754686 chr2:136603276 T/C cg15123519 chr2:136567270 LCT 0.33 6.39 0.33 5.56e-10 Mosquito bite size; CRC cis rs763121 0.962 rs138711 chr22:39139913 C/T cg06022373 chr22:39101656 GTPBP1 0.74 7.21 0.37 3.93e-12 Menopause (age at onset); CRC cis rs13191362 1.000 rs13201023 chr6:162981381 C/G cg14584255 chr6:163149320 PACRG;PARK2 0.36 5.78 0.3 1.71e-8 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs61897795 0.628 rs174579 chr11:61605613 C/T cg00603274 chr11:61596626 FADS2 -0.63 -7.77 -0.39 1.04e-13 Neutrophil count;Sum basophil neutrophil counts; CRC cis rs7527798 0.592 rs6657161 chr1:207847128 C/T cg21110645 chr1:207815933 NA -0.39 -5.83 -0.31 1.29e-8 Erythrocyte sedimentation rate; CRC cis rs2294693 0.891 rs4714420 chr6:40992799 T/C cg14769373 chr6:40998127 UNC5CL -0.48 -6.37 -0.33 6.37e-10 Gastric cancer;Non-cardia gastric cancer; CRC cis rs11212617 0.935 rs4623864 chr11:108051300 A/G cg12106634 chr11:108092400 ATM;NPAT 0.42 6.33 0.33 7.92e-10 Response to metformin in type 2 diabetes (glycemic); CRC cis rs1801251 0.964 rs7589201 chr2:233724536 A/G cg25237894 chr2:233734115 C2orf82 -0.48 -7.64 -0.39 2.39e-13 Coronary artery disease; CRC cis rs2252790 0.965 rs2501048 chr6:116663479 C/G cg18764771 chr6:116381957 FRK -0.22 -5.8 -0.3 1.59e-8 Fast beta electroencephalogram; CRC cis rs2635047 0.542 rs2668772 chr18:44770621 T/G cg19077165 chr18:44547161 KATNAL2 -0.4 -5.96 -0.31 6.51e-9 Educational attainment; CRC cis rs1801251 1.000 rs778166 chr2:233664097 A/T cg25237894 chr2:233734115 C2orf82 0.54 8.82 0.44 7.06e-17 Coronary artery disease; CRC cis rs4319547 1.000 rs6489156 chr12:123100397 C/T cg05707623 chr12:122985044 ZCCHC8 -0.69 -8.78 -0.44 9.04e-17 Body mass index; CRC cis rs3733585 0.664 rs17245436 chr4:9958169 A/G cg11266682 chr4:10021025 SLC2A9 -0.47 -9.63 -0.47 1.69e-19 Cleft plate (environmental tobacco smoke interaction); CRC cis rs9527 0.830 rs12249194 chr10:104643698 T/C cg04362960 chr10:104952993 NT5C2 0.63 8.36 0.42 1.81e-15 Arsenic metabolism; CRC cis rs2038227 1 rs2038227 chr16:539140 C/A cg02296627 chr16:508045 RAB11FIP3 -0.38 -6.68 -0.35 9.99e-11 Venous thromboembolism (SNP x SNP interaction); CRC cis rs11031096 0.502 rs7935824 chr11:4046900 C/G cg18678763 chr11:4115507 RRM1 -0.49 -8.2 -0.41 5.62e-15 Mean corpuscular volume;Mean corpuscular hemoglobin; CRC cis rs9311676 0.632 rs56281646 chr3:58424917 G/A cg06643156 chr3:58380774 PXK 0.43 6.53 0.34 2.5e-10 Systemic lupus erythematosus; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg05388307 chr4:166248715 SC4MOL 0.46 6.16 0.32 2.09e-9 Anxiety disorder; CRC cis rs68170813 0.559 rs75203426 chr7:107017589 G/C cg02696742 chr7:106810147 HBP1 -0.57 -6.19 -0.32 1.81e-9 Coronary artery disease; CRC cis rs7849270 0.801 rs10819474 chr9:131930494 C/T cg13538475 chr9:131942899 NA -0.31 -6.06 -0.32 3.81e-9 Blood metabolite ratios; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg10020897 chr1:167905730 BRP44;DCAF6 0.43 6.17 0.32 2.03e-9 Intelligence (multi-trait analysis); CRC cis rs826838 1.000 rs11168217 chr12:38884278 T/C cg26384229 chr12:38710491 ALG10B 0.76 10.52 0.5 1.63e-22 Heart rate; CRC cis rs79839061 0.610 rs9994159 chr4:891150 C/T cg07828340 chr4:882639 GAK 1.17 11.73 0.54 8.82e-27 Intelligence (multi-trait analysis); CRC cis rs6141769 0.542 rs6058819 chr20:31303942 T/C cg13636640 chr20:31349939 DNMT3B -0.39 -5.92 -0.31 8.02e-9 Subjective well-being; CRC cis rs951366 0.617 rs9438393 chr1:205782718 A/G cg11965913 chr1:205819406 PM20D1 1.02 19.31 0.73 4.47e-56 Menarche (age at onset); CRC cis rs66887589 0.807 rs13134517 chr4:120405262 G/A cg09307838 chr4:120376055 NA 0.55 8.48 0.42 7.98e-16 Diastolic blood pressure; CRC cis rs2243480 1.000 rs2420170 chr7:65656053 T/C cg18252515 chr7:66147081 NA 1.26 14.39 0.62 9.53e-37 Diabetic kidney disease; CRC cis rs597539 0.652 rs569777 chr11:68706848 G/A cg06112835 chr11:68658793 MRPL21 0.42 6.71 0.35 8.36e-11 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC trans rs7618501 1.000 rs7431106 chr3:49808374 G/A cg21582582 chr3:182698605 DCUN1D1 0.56 8.35 0.42 1.88e-15 Intelligence (multi-trait analysis); CRC cis rs644799 0.672 rs11021307 chr11:95501407 C/T cg03916912 chr11:95522834 CEP57;FAM76B 0.86 15.59 0.65 2.1e-41 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs10791323 0.593 rs2156676 chr11:133715791 G/C cg06766960 chr11:133703094 NA -0.34 -5.69 -0.3 2.82e-8 Childhood ear infection; CRC cis rs7705042 0.761 rs10062349 chr5:141509597 G/A cg08523384 chr5:141488047 NDFIP1 -0.32 -5.77 -0.3 1.87e-8 Asthma; CRC trans rs9291683 0.526 rs7695555 chr4:10001656 T/C cg26043149 chr18:55253948 FECH 0.45 6.86 0.35 3.43e-11 Bone mineral density; CRC cis rs2576037 0.526 rs4258717 chr18:44456954 T/C cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.56 9.55 0.47 3.13e-19 Personality dimensions; CRC cis rs4268898 0.662 rs72793208 chr2:24510284 C/T cg06627628 chr2:24431161 ITSN2 -0.83 -11.62 -0.54 2.25e-26 Asthma; CRC cis rs28830936 0.510 rs2412640 chr15:42124082 C/T cg17847044 chr15:42102381 MAPKBP1 0.34 8.03 0.4 1.72e-14 Diastolic blood pressure; CRC cis rs1018836 0.892 rs10103198 chr8:91579436 A/T cg16814680 chr8:91681699 NA -0.53 -8.33 -0.42 2.28e-15 Ejection fraction in Tripanosoma cruzi seropositivity; CRC cis rs8180040 0.764 rs2132173 chr3:47247060 C/T cg27129171 chr3:47204927 SETD2 -0.63 -10.2 -0.49 2.1e-21 Colorectal cancer; CRC cis rs6951245 1.000 rs11766526 chr7:1101433 G/A cg03188948 chr7:1209495 NA 0.65 6.84 0.35 3.8e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs4688759 0.609 rs113176147 chr3:49534439 G/T cg00383909 chr3:49044727 WDR6 1.33 10.88 0.51 9.18e-24 Blood protein levels; CRC trans rs1005277 0.579 rs2474569 chr10:38383491 C/G cg23533926 chr12:111358616 MYL2 -0.52 -7.85 -0.4 6.11e-14 Extrinsic epigenetic age acceleration; CRC cis rs6502050 0.835 rs34673303 chr17:80085144 G/C cg22110888 chr17:80059540 CCDC57 -0.41 -6.39 -0.33 5.58e-10 Life satisfaction; CRC cis rs1158570 0.564 rs2554372 chr8:131333913 A/G cg21674704 chr8:131455249 NA -0.38 -5.76 -0.3 1.95e-8 Platelet count; CRC cis rs1799949 1.000 rs3092988 chr17:41201702 C/T cg23758822 chr17:41437982 NA 0.8 13.61 0.6 9.31e-34 Menopause (age at onset); CRC cis rs853679 0.517 rs9380065 chr6:28144751 A/G cg23161317 chr6:28129485 ZNF389 0.54 6.47 0.34 3.49e-10 Depression; CRC cis rs947211 1.000 rs823144 chr1:205744546 C/A cg11965913 chr1:205819406 PM20D1 0.45 6.39 0.33 5.62e-10 Parkinson's disease; CRC trans rs1814175 0.817 rs11493756 chr11:50017885 T/C cg15704280 chr7:45808275 SEPT13 -0.97 -19.11 -0.73 2.72e-55 Height; CRC cis rs2067615 0.560 rs10467028 chr12:107076405 A/G cg13491945 chr12:107078410 RFX4 0.35 5.93 0.31 7.75e-9 Heart rate; CRC cis rs75422866 0.510 rs73105812 chr12:48118187 C/A cg14736327 chr12:48174669 SLC48A1 -0.72 -5.75 -0.3 2.05e-8 Pneumonia; CRC cis rs10256972 0.591 rs10229680 chr7:1158565 C/T cg22907277 chr7:1156413 C7orf50 0.75 11.55 0.54 3.93e-26 Longevity;Endometriosis; CRC cis rs4319547 0.915 rs7316734 chr12:123117425 A/G cg23029597 chr12:123009494 RSRC2 -0.61 -7.8 -0.4 8.02e-14 Body mass index; CRC cis rs10512697 0.803 rs13174189 chr5:3579174 G/T cg19473799 chr5:3511975 NA 0.7 5.73 0.3 2.22e-8 Immune response to smallpox vaccine (IL-6); CRC cis rs12190007 0.508 rs6605538 chr6:169731432 G/A cg16388071 chr6:169726476 NA 0.45 6.98 0.36 1.6e-11 Obesity-related traits; CRC cis rs9903692 0.866 rs11079807 chr17:46176047 T/C cg21215337 chr17:46176117 CBX1 -0.43 -7.95 -0.4 2.95e-14 Pulse pressure; CRC cis rs2637266 0.519 rs2395383 chr10:78300806 C/T cg18941641 chr10:78392320 NA -0.36 -6.02 -0.32 4.57e-9 Pulmonary function; CRC cis rs7833790 0.963 rs7836040 chr8:82698328 G/A cg27398817 chr8:82754497 SNX16 -0.5 -6.04 -0.32 4.1e-9 Diastolic blood pressure; CRC cis rs6951245 0.832 rs79808627 chr7:1092519 C/G cg07217954 chr7:1067459 C7orf50 0.5 5.77 0.3 1.8e-8 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC trans rs11098499 0.754 rs11098502 chr4:120252063 T/A cg25214090 chr10:38739885 LOC399744 0.53 8.36 0.42 1.81e-15 Corneal astigmatism; CRC cis rs7618915 0.570 rs4687633 chr3:52630548 G/A cg11645453 chr3:52864694 ITIH4 0.35 6.05 0.32 3.99e-9 Bipolar disorder; CRC cis rs28386778 0.830 rs67905415 chr17:61841236 G/A cg06601766 chr17:61851465 DDX42;CCDC47 0.43 5.92 0.31 8.09e-9 Prudent dietary pattern; CRC cis rs4665809 0.878 rs4143538 chr2:26290178 A/C cg26119090 chr2:26468346 HADHA;HADHB -0.67 -8.25 -0.41 3.77e-15 Gut microbiome composition (summer); CRC cis rs4654899 0.895 rs10916866 chr1:21137768 C/A cg02927042 chr1:21476669 EIF4G3 0.38 5.93 0.31 7.5e-9 Superior frontal gyrus grey matter volume; CRC cis rs7762018 0.941 rs4716387 chr6:170136777 G/C cg24289452 chr6:170231220 NA -0.54 -5.94 -0.31 7.19e-9 Thiazide-induced adverse metabolic effects in hypertensive patients; CRC cis rs17376456 1.000 rs56046246 chr5:93531545 T/G cg09848695 chr5:92956644 FAM172A;MIR2277 0.65 5.68 0.3 2.96e-8 Diabetic retinopathy; CRC cis rs8017423 0.647 rs12895269 chr14:90822430 T/C cg14092571 chr14:90743983 NA 0.38 5.92 0.31 8.07e-9 Mortality in heart failure; CRC cis rs4319547 0.956 rs10773302 chr12:123043145 G/T cg05707623 chr12:122985044 ZCCHC8 -0.74 -9.66 -0.47 1.31e-19 Body mass index; CRC cis rs9611565 0.512 rs132767 chr22:42009520 C/T cg03806693 chr22:41940476 POLR3H -0.98 -11.47 -0.53 7.52e-26 Vitiligo; CRC cis rs60871478 1.000 rs4720930 chr7:808073 G/A cg05535760 chr7:792225 HEATR2 0.81 10.57 0.5 1.1e-22 Cerebrospinal P-tau181p levels; CRC cis rs1401999 0.565 rs4912515 chr3:183653718 A/G cg01324343 chr3:183735012 ABCC5 0.59 9.48 0.46 5.11e-19 Anterior chamber depth; CRC cis rs7927592 0.731 rs2156463 chr11:68386311 T/C cg16797656 chr11:68205561 LRP5 0.49 8.96 0.44 2.49e-17 Total body bone mineral density; CRC cis rs3736485 0.873 rs7162563 chr15:51775067 T/C cg08986416 chr15:51914746 DMXL2 -0.45 -6.44 -0.33 4.25e-10 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs9457247 0.967 rs1590257 chr6:167377782 G/T cg23791538 chr6:167370224 RNASET2 0.39 6.09 0.32 3.22e-9 Crohn's disease; CRC cis rs7725052 0.609 rs4342370 chr5:40460902 A/G cg09067459 chr5:40385259 NA -0.4 -6.68 -0.35 9.91e-11 Pediatric autoimmune diseases; CRC cis rs1552244 0.572 rs2054478 chr3:10172211 C/T cg08888203 chr3:10149979 C3orf24 0.74 9.0 0.44 1.82e-17 Alzheimer's disease; CRC cis rs10504229 1.000 rs73609747 chr8:58189104 G/C cg01721255 chr8:58191610 C8orf71 0.49 6.17 0.32 2e-9 Developmental language disorder (linguistic errors); CRC cis rs8072100 0.688 rs8075843 chr17:45442363 C/T cg25173405 chr17:45401733 C17orf57 -0.46 -7.07 -0.36 9.29e-12 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs6502050 0.835 rs34199331 chr17:80134487 C/T cg02741985 chr17:80059408 CCDC57 0.44 7.13 0.37 6.31e-12 Life satisfaction; CRC cis rs7914558 0.966 rs3977751 chr10:104920232 A/G cg04362960 chr10:104952993 NT5C2 0.61 9.17 0.45 5.11e-18 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs7945718 0.870 rs3890064 chr11:12758766 C/A cg25843174 chr11:12811716 TEAD1 0.45 8.45 0.42 9.44e-16 Educational attainment (years of education); CRC cis rs9733 0.596 rs6681990 chr1:150695929 A/G cg15448220 chr1:150897856 SETDB1 0.45 6.41 0.33 5.09e-10 Tonsillectomy; CRC cis rs7809950 1.000 rs7793613 chr7:107250484 C/T cg23024343 chr7:107201750 COG5 -0.62 -8.99 -0.44 1.94e-17 Coronary artery disease; CRC cis rs9372498 0.505 rs62422247 chr6:118987559 G/T cg18833306 chr6:118973337 C6orf204 0.46 5.78 0.3 1.73e-8 Diastolic blood pressure; CRC cis rs8177179 0.967 rs6782434 chr3:133438834 C/G cg24879335 chr3:133465180 TF 0.49 9.72 0.47 8.66e-20 Iron status biomarkers (transferrin levels); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg07305049 chr22:21354332 THAP7 -0.38 -6.46 -0.34 3.82e-10 Liver disease severity in Alagille syndrome; CRC cis rs2839186 0.934 rs4819221 chr21:47695417 G/T cg09417038 chr21:47716443 C21orf57 0.41 6.86 0.35 3.43e-11 Testicular germ cell tumor; CRC cis rs1775148 1 rs1775148 chr1:205757824 C/T cg07167872 chr1:205819463 PM20D1 0.4 6.0 0.31 5.27e-9 Prostate cancer; CRC cis rs35306767 0.715 rs11253539 chr10:1011347 G/A cg20503657 chr10:835505 NA 0.91 10.86 0.51 1.08e-23 Eosinophil percentage of granulocytes; CRC trans rs2727020 0.636 rs11040368 chr11:49453602 C/A cg11707556 chr5:10655725 ANKRD33B -0.38 -7.18 -0.37 4.72e-12 Coronary artery disease; CRC cis rs17401966 0.540 rs3748581 chr1:10441664 T/C cg19773385 chr1:10388646 KIF1B -0.47 -7.52 -0.38 5.13e-13 Hepatocellular carcinoma; CRC cis rs10986311 0.748 rs10986333 chr9:127168391 T/A cg14243010 chr9:127117328 LOC100129034;PSMB7 -0.39 -5.72 -0.3 2.39e-8 Vitiligo; CRC cis rs6089584 0.546 rs6061978 chr20:60615604 C/T cg23463467 chr20:60627584 TAF4 0.41 7.55 0.38 4.31e-13 Body mass index; CRC cis rs9303401 0.659 rs17222621 chr17:56695923 C/T cg02118635 chr17:56770003 RAD51C;TEX14 0.79 9.9 0.48 2.16e-20 Cognitive test performance; CRC cis rs3213545 0.700 rs10849829 chr12:121470256 A/G cg02403541 chr12:121454288 C12orf43 -0.45 -7.11 -0.37 7.18e-12 Subjective well-being;Cardiovascular disease risk factors; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg06936779 chr1:151171405 PIP5K1A 0.44 6.92 0.36 2.37e-11 Liver disease severity in Alagille syndrome; CRC cis rs6951245 1.000 rs78185801 chr7:1096367 G/A cg07217954 chr7:1067459 C7orf50 0.55 5.72 0.3 2.36e-8 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs425277 0.583 rs10910046 chr1:2041155 C/T cg12639453 chr1:2035780 PRKCZ -0.38 -7.27 -0.37 2.62e-12 Height; CRC cis rs7586879 0.789 rs36029941 chr2:25127801 C/T cg22495460 chr2:25135724 ADCY3 -0.88 -15.19 -0.64 7.57e-40 Body mass index; CRC cis rs10504229 0.906 rs61638902 chr8:58193511 A/C cg05313129 chr8:58192883 C8orf71 -0.44 -7.14 -0.37 5.96e-12 Developmental language disorder (linguistic errors); CRC trans rs7647973 0.626 rs11130217 chr3:49737323 A/G cg21659725 chr3:3221576 CRBN -0.64 -7.0 -0.36 1.46e-11 Menarche (age at onset); CRC cis rs6860806 0.507 rs272892 chr5:131664349 C/T cg18301423 chr5:131593218 PDLIM4 0.37 6.25 0.33 1.29e-9 Breast cancer; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg26933068 chr19:19976613 ZNF253 0.4 6.47 0.34 3.56e-10 Liver disease severity in Alagille syndrome; CRC cis rs5769765 0.908 rs138866 chr22:50205903 A/G cg04121214 chr22:50244548 NA -0.43 -6.66 -0.34 1.15e-10 Schizophrenia; CRC cis rs67311347 1.000 rs73078164 chr3:40480289 G/A cg09455208 chr3:40491958 NA 0.49 9.63 0.47 1.66e-19 Renal cell carcinoma; CRC trans rs5756813 0.668 rs5756805 chr22:38144618 A/G cg19894588 chr14:64061835 NA -0.47 -6.13 -0.32 2.55e-9 Optic cup area;Vertical cup-disc ratio; CRC cis rs9359856 0.529 rs56352205 chr6:90439272 C/T cg13799429 chr6:90582589 CASP8AP2 -0.75 -7.61 -0.39 2.88e-13 Bipolar disorder; CRC cis rs908922 0.627 rs11590073 chr1:152500810 C/T cg23254163 chr1:152506842 NA 0.5 10.17 0.49 2.65e-21 Hair morphology; CRC cis rs4547160 0.606 rs36108998 chr12:63477075 T/C cg26727693 chr12:63544175 AVPR1A -0.43 -7.83 -0.4 6.9e-14 Morning vs. evening chronotype; CRC cis rs4862750 0.914 rs6553028 chr4:187876046 T/C cg03647317 chr4:187891568 NA -0.54 -9.75 -0.47 6.58e-20 Lobe attachment (rater-scored or self-reported); CRC cis rs8044995 0.563 rs1110572 chr16:68396119 A/G cg09835421 chr16:68378352 PRMT7 -0.69 -7.19 -0.37 4.38e-12 Schizophrenia; CRC cis rs4638749 1.000 rs12616140 chr2:108867728 A/G cg25838818 chr2:108905173 SULT1C2 -0.37 -5.94 -0.31 7.18e-9 Blood pressure; CRC cis rs951366 0.764 rs823141 chr1:205741426 T/C cg26354017 chr1:205819088 PM20D1 0.74 11.35 0.53 2.08e-25 Menarche (age at onset); CRC cis rs4870684 0.509 rs11763804 chr7:57702125 G/C cg01314568 chr7:57830625 NA -0.61 -7.28 -0.37 2.45e-12 Bipolar disorder and schizophrenia; CRC cis rs593982 0.920 rs618456 chr11:65475620 C/T cg08755490 chr11:65554678 OVOL1 0.94 10.07 0.49 5.79e-21 Atopic dermatitis; CRC trans rs875971 0.660 rs2191268 chr7:66110224 C/T cg17879804 chr3:44752500 NA 0.42 6.87 0.35 3.29e-11 Aortic root size; CRC cis rs2839186 0.619 rs55689527 chr21:47622727 A/G cg09417038 chr21:47716443 C21orf57 -0.38 -6.45 -0.33 4.03e-10 Testicular germ cell tumor; CRC cis rs1448094 0.512 rs11832992 chr12:86240790 T/C cg02569458 chr12:86230093 RASSF9 0.43 7.34 0.38 1.68e-12 Major depressive disorder; CRC cis rs4363385 0.818 rs409986 chr1:153014741 A/C cg25856811 chr1:152973957 SPRR3 0.26 7.28 0.37 2.51e-12 Inflammatory skin disease; CRC trans rs7395662 0.500 rs10838984 chr11:48640485 C/T cg00717180 chr2:96193071 NA -0.37 -6.08 -0.32 3.3e-9 HDL cholesterol; CRC cis rs2180341 1.000 rs9388561 chr6:127634921 C/T cg24812749 chr6:127587940 RNF146 0.95 13.75 0.6 2.59e-34 Breast cancer; CRC cis rs2842992 0.747 rs9365095 chr6:160192928 T/G cg11366901 chr6:160182831 ACAT2 0.97 14.26 0.62 2.99e-36 Age-related macular degeneration (geographic atrophy); CRC cis rs11212617 0.967 rs11212616 chr11:108281322 T/A cg01991180 chr11:108092276 ATM;NPAT 0.42 6.09 0.32 3.2e-9 Response to metformin in type 2 diabetes (glycemic); CRC cis rs2072499 0.750 rs55675376 chr1:156165881 C/T cg24450063 chr1:156163899 SLC25A44 1.07 16.89 0.68 1.56e-46 Testicular germ cell tumor; CRC cis rs4481887 0.538 rs4916117 chr1:248387187 G/C cg00666640 chr1:248458726 OR2T12 0.46 7.2 0.37 4.14e-12 Common traits (Other); CRC trans rs9388451 0.772 rs1268064 chr6:126042578 G/A cg05039488 chr6:79577232 IRAK1BP1 0.55 8.16 0.41 7.16e-15 Brugada syndrome; CRC cis rs11971779 0.715 rs11772771 chr7:139058803 T/C cg07862535 chr7:139043722 LUC7L2 0.8 10.48 0.5 2.22e-22 Diisocyanate-induced asthma; CRC cis rs116095464 0.614 rs10059220 chr5:242813 C/T cg22857025 chr5:266934 NA -1.16 -12.11 -0.56 3.61e-28 Breast cancer; CRC cis rs1499614 1.000 rs2707832 chr7:66136549 C/T cg12463550 chr7:65579703 CRCP 0.64 6.0 0.31 5.21e-9 Gout; CRC cis rs9325144 0.600 rs10748442 chr12:38732939 A/T cg26384229 chr12:38710491 ALG10B 0.53 7.99 0.4 2.29e-14 Morning vs. evening chronotype; CRC trans rs7127307 0.740 rs4144896 chr11:128182026 C/T cg25721452 chr12:102133339 SYCP3 0.49 6.16 0.32 2.08e-9 Atopic dermatitis; CRC trans rs12699921 0.632 rs2723494 chr7:17853983 C/T cg15753394 chr6:17282781 RBM24 -0.36 -6.0 -0.31 5.32e-9 Fibrinogen levels; CRC cis rs10540 1.000 rs12421457 chr11:505780 T/C cg03352830 chr11:487213 PTDSS2 0.67 7.71 0.39 1.48e-13 Body mass index; CRC cis rs9443645 0.901 rs9443632 chr6:79664440 T/C cg09184832 chr6:79620586 NA -0.51 -9.4 -0.46 9.67e-19 Intelligence (multi-trait analysis); CRC cis rs7618915 0.547 rs34017441 chr3:52742413 T/C cg10802521 chr3:52805072 NEK4 -0.59 -9.03 -0.45 1.45e-17 Bipolar disorder; CRC cis rs4076764 0.830 rs10917770 chr1:163442214 G/C cg06092702 chr1:163392909 NA -0.56 -8.67 -0.43 1.98e-16 Motion sickness; CRC cis rs9733 0.544 rs2867302 chr1:150653650 T/C cg15448220 chr1:150897856 SETDB1 0.45 6.44 0.33 4.24e-10 Tonsillectomy; CRC cis rs4665809 0.549 rs62130460 chr2:26472718 T/C cg22920501 chr2:26401640 FAM59B 0.84 11.0 0.52 3.6e-24 Gut microbiome composition (summer); CRC cis rs473651 0.935 rs578510 chr2:239343140 C/T cg18131467 chr2:239335373 ASB1 1.04 23.48 0.79 2.69e-72 Multiple system atrophy; CRC cis rs9463078 0.625 rs7742360 chr6:44998692 C/G cg25276700 chr6:44698697 NA -0.26 -6.22 -0.32 1.51e-9 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; CRC cis rs9457247 1.000 rs430477 chr6:167389851 T/C cg23791538 chr6:167370224 RNASET2 -0.38 -5.97 -0.31 6.08e-9 Crohn's disease; CRC cis rs9928842 0.770 rs8048371 chr16:75275547 C/T cg09066997 chr16:75300724 BCAR1 0.72 7.11 0.37 7.21e-12 Alcoholic chronic pancreatitis; CRC cis rs6496044 0.568 rs1351196 chr15:86077404 T/C cg17133734 chr15:86042851 AKAP13 0.39 6.31 0.33 8.78e-10 Interstitial lung disease; CRC cis rs6951245 0.554 rs58210047 chr7:1149381 G/A cg22907277 chr7:1156413 C7orf50 0.87 11.29 0.53 3.27e-25 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC trans rs7165102 1.000 rs627804 chr15:65734040 A/C cg22383888 chr3:27764816 EOMES -0.29 -6.09 -0.32 3.11e-9 Mean corpuscular hemoglobin; CRC trans rs4332037 0.754 rs62436669 chr7:1926636 G/A cg11693508 chr17:37793320 STARD3 0.7 8.53 0.43 5.36e-16 Bipolar disorder; CRC trans rs10982213 0.830 rs2274163 chr9:117188714 C/T cg26155979 chr10:105110866 PCGF6 0.34 6.04 0.32 4.24e-9 Interleukin-6 levels; CRC cis rs533581 0.866 rs562812 chr16:88970944 G/A cg05579598 chr16:88989069 CBFA2T3 0.36 7.1 0.36 7.62e-12 Social autistic-like traits; CRC cis rs4400599 0.618 rs4845610 chr1:154205428 T/C cg26808167 chr1:154192205 UBAP2L;C1orf43 -0.37 -5.73 -0.3 2.22e-8 Platelet distribution width; CRC cis rs9487051 0.714 rs6930733 chr6:109631587 T/C cg12927641 chr6:109611667 NA -0.36 -6.38 -0.33 6.1e-10 Reticulocyte fraction of red cells; CRC cis rs9491140 0.539 rs980656 chr6:124690303 A/G cg22366943 chr6:124882293 NKAIN2 0.53 7.98 0.4 2.46e-14 Neuroticism; CRC cis rs17253792 0.545 rs34719936 chr14:56015134 G/A cg01858014 chr14:56050164 KTN1 -0.85 -6.17 -0.32 2.02e-9 Putamen volume; CRC cis rs35000415 0.938 rs12536266 chr7:128611035 G/A cg19972273 chr7:128594194 NA 0.66 6.03 0.32 4.32e-9 Systemic lupus erythematosus; CRC cis rs72781680 0.821 rs72796369 chr2:24162663 G/T cg08917208 chr2:24149416 ATAD2B 0.56 6.76 0.35 6.37e-11 Lymphocyte counts; CRC cis rs1046896 0.553 rs9893885 chr17:80837107 C/T cg17346650 chr17:80929145 B3GNTL1 0.48 7.05 0.36 1.09e-11 Glycated hemoglobin levels; CRC cis rs9322193 0.884 rs62439836 chr6:149990309 A/G cg05861140 chr6:150128134 PCMT1 -0.37 -5.92 -0.31 8.12e-9 Lung cancer; CRC cis rs11758351 0.587 rs16891456 chr6:26234127 T/C cg01420254 chr6:26195488 NA 0.73 8.07 0.41 1.31e-14 Gout;Renal underexcretion gout; CRC cis rs270601 0.837 rs367805 chr5:131701279 T/C cg18758796 chr5:131593413 PDLIM4 0.39 6.31 0.33 9.03e-10 Acylcarnitine levels; CRC cis rs7618915 0.501 rs34754793 chr3:52629177 A/T cg18404041 chr3:52824283 ITIH1 -0.41 -8.61 -0.43 3.02e-16 Bipolar disorder; CRC cis rs7223966 1.000 rs992416 chr17:61745905 A/C cg23090583 chr17:61904693 PSMC5;FTSJ3 0.48 6.08 0.32 3.33e-9 Hip circumference adjusted for BMI;Body mass index; CRC cis rs7264396 0.887 rs6120954 chr20:34059536 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.38 -6.2 -0.32 1.68e-9 Total cholesterol levels; CRC cis rs7666738 0.830 rs17027198 chr4:98991085 G/C cg17366294 chr4:99064904 C4orf37 0.43 7.3 0.37 2.2e-12 Colonoscopy-negative controls vs population controls; CRC cis rs7618915 0.570 rs4687633 chr3:52630548 G/A cg07507251 chr3:52567010 NT5DC2 0.42 6.06 0.32 3.62e-9 Bipolar disorder; CRC cis rs898097 0.805 rs60233158 chr17:80896612 A/G cg03160526 chr17:80928410 B3GNTL1 0.44 6.35 0.33 7.27e-10 Breast cancer; CRC cis rs597539 0.652 rs584108 chr11:68630282 A/T cg06112835 chr11:68658793 MRPL21 -0.45 -7.34 -0.38 1.69e-12 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs7927771 0.832 rs11039212 chr11:47393303 A/T cg18512352 chr11:47633146 NA 0.36 7.06 0.36 1.02e-11 Subjective well-being; CRC cis rs28386778 0.863 rs2727355 chr17:61931790 C/T cg07362569 chr17:61921086 SMARCD2 0.36 5.6 0.3 4.41e-8 Prudent dietary pattern; CRC cis rs72634258 0.554 rs12061787 chr1:7888730 G/C cg26816564 chr1:7831052 VAMP3 0.84 9.32 0.46 1.7e-18 Inflammatory bowel disease; CRC cis rs4074961 0.669 rs4652964 chr1:38078300 A/G cg13401533 chr1:37979913 MEAF6 0.42 5.95 0.31 6.99e-9 Axial length; CRC cis rs4862750 0.872 rs7679956 chr4:187900229 C/T cg08901578 chr4:187885870 NA -0.33 -5.89 -0.31 9.7e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs9660992 0.710 rs1668867 chr1:205240251 C/T cg21643547 chr1:205240462 TMCC2 -0.47 -7.73 -0.39 1.33e-13 Mean corpuscular volume;Mean platelet volume; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg14640751 chr11:111636595 PPP2R1B 0.49 6.47 0.34 3.49e-10 Thyroid stimulating hormone; CRC cis rs9393692 0.557 rs2893820 chr6:26295686 G/A cg00631329 chr6:26305371 NA -0.53 -8.86 -0.44 5.06e-17 Educational attainment; CRC cis rs2396545 0.634 rs35788385 chr11:570094 G/A cg16486109 chr11:613632 IRF7 0.69 10.89 0.51 8.63e-24 Systemic lupus erythematosus and Systemic sclerosis; CRC cis rs2032447 0.670 rs198850 chr6:26104670 A/C cg03517284 chr6:25882590 NA 0.43 5.92 0.31 8.25e-9 Intelligence (multi-trait analysis); CRC cis rs4499344 0.633 rs259258 chr19:33152523 A/G cg08127369 chr19:33164662 ANKRD27 0.39 5.95 0.31 6.82e-9 Mean platelet volume; CRC cis rs4843747 0.697 rs72818533 chr16:88073841 G/A cg17633681 chr16:88106987 BANP 0.8 13.72 0.6 3.32e-34 Menopause (age at onset); CRC trans rs10982213 0.830 rs2274163 chr9:117188714 C/T cg25721516 chr17:42276931 ATXN7L3 0.39 6.08 0.32 3.39e-9 Interleukin-6 levels; CRC cis rs9291683 0.595 rs35250962 chr4:10048271 C/T cg00071950 chr4:10020882 SLC2A9 0.67 12.76 0.58 1.47e-30 Bone mineral density; CRC cis rs916888 0.610 rs199444 chr17:44818276 T/C cg01570182 chr17:44337453 NA 0.77 9.71 0.47 9.48e-20 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs4363385 0.747 rs6704105 chr1:152964397 C/G cg25856811 chr1:152973957 SPRR3 -0.25 -7.06 -0.36 9.83e-12 Inflammatory skin disease; CRC cis rs6089584 0.927 rs1886007 chr20:60581049 G/A cg23262073 chr20:60523788 NA -0.41 -6.94 -0.36 2.1e-11 Body mass index; CRC cis rs2303759 0.507 rs1465696 chr19:49837439 G/A cg22590775 chr19:49891494 CCDC155 0.61 5.85 0.31 1.21e-8 Multiple sclerosis; CRC cis rs3091242 0.933 rs12402120 chr1:25751632 C/T cg27572855 chr1:25598939 RHD 0.35 6.25 0.33 1.24e-9 Erythrocyte sedimentation rate; CRC cis rs7586879 0.752 rs11683748 chr2:25130434 C/T cg04586622 chr2:25135609 ADCY3 -0.58 -9.93 -0.48 1.67e-20 Body mass index; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg13645704 chr7:6522802 KDELR2 0.43 6.4 0.33 5.35e-10 Intelligence (multi-trait analysis); CRC cis rs7914558 0.966 rs3902934 chr10:104746649 A/G cg04362960 chr10:104952993 NT5C2 0.63 9.56 0.47 2.86e-19 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs11971779 0.680 rs7805767 chr7:139111415 A/G cg07862535 chr7:139043722 LUC7L2 0.57 7.32 0.37 1.92e-12 Diisocyanate-induced asthma; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg01591470 chr14:39736043 CTAGE5 -0.41 -6.17 -0.32 2.03e-9 Myopia (pathological); CRC cis rs2354432 0.607 rs2353999 chr1:146830686 T/C cg25205988 chr1:146714368 CHD1L -1.23 -10.17 -0.49 2.65e-21 Mitochondrial DNA levels; CRC trans rs7395662 0.927 rs4882141 chr11:48627525 C/T cg21153622 chr11:89784906 NA -0.44 -7.05 -0.36 1.06e-11 HDL cholesterol; CRC cis rs2658782 0.789 rs2259633 chr11:93141580 C/A cg15737290 chr11:93063684 CCDC67 0.46 6.71 0.35 8.6e-11 Pulmonary function decline; CRC cis rs9457247 0.765 rs1060404 chr6:167429467 A/G cg07741184 chr6:167504864 NA 0.39 6.65 0.34 1.23e-10 Crohn's disease; CRC trans rs12599106 0.792 rs76039834 chr16:34598453 G/A cg03395511 chr6:291903 DUSP22 -0.51 -7.03 -0.36 1.19e-11 Menopause (age at onset); CRC cis rs977987 0.843 rs2059256 chr16:75395835 G/T cg03315344 chr16:75512273 CHST6 0.52 8.81 0.44 7.42e-17 Dupuytren's disease; CRC cis rs13118159 0.872 rs4974605 chr4:1346389 C/G cg21620606 chr4:1342894 KIAA1530 0.4 7.06 0.36 9.95e-12 Longevity; CRC cis rs10504229 0.906 rs113745779 chr8:58191301 C/G cg24829409 chr8:58192753 C8orf71 -0.68 -11.34 -0.53 2.27e-25 Developmental language disorder (linguistic errors); CRC cis rs7552404 0.731 rs10873788 chr1:76367857 A/C cg03433033 chr1:76189801 ACADM 0.64 8.0 0.4 2.14e-14 Blood metabolite levels;Acylcarnitine levels; CRC cis rs2991971 0.934 rs11211129 chr1:45983080 C/T cg24296786 chr1:45957014 TESK2 0.57 8.56 0.43 4.54e-16 High light scatter reticulocyte count; CRC cis rs7927592 0.956 rs12277225 chr11:68340967 T/C cg16797656 chr11:68205561 LRP5 0.36 5.65 0.3 3.55e-8 Total body bone mineral density; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg26742440 chr11:73472391 RAB6A 0.51 6.81 0.35 4.58e-11 Thyroid stimulating hormone; CRC cis rs1018836 0.923 rs13254212 chr8:91582355 T/C cg16814680 chr8:91681699 NA -0.73 -11.89 -0.55 2.35e-27 Ejection fraction in Tripanosoma cruzi seropositivity; CRC cis rs736408 0.507 rs6445531 chr3:52717282 T/C cg18404041 chr3:52824283 ITIH1 -0.4 -8.44 -0.42 1.04e-15 Bipolar disorder; CRC cis rs9875589 0.509 rs6783645 chr3:14024542 T/C cg14375111 chr3:14165186 TMEM43;CHCHD4 0.4 5.85 0.31 1.16e-8 Ovarian reserve; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg16527794 chr11:47600580 NDUFS3;KBTBD4 0.37 6.16 0.32 2.15e-9 Liver disease severity in Alagille syndrome; CRC cis rs9467711 0.516 rs548987 chr6:25869371 C/G cg08501292 chr6:25962987 TRIM38 0.55 6.35 0.33 7.25e-10 Autism spectrum disorder or schizophrenia; CRC cis rs2842992 0.789 rs4709370 chr6:160210061 A/G cg11366901 chr6:160182831 ACAT2 0.96 13.8 0.61 1.7e-34 Age-related macular degeneration (geographic atrophy); CRC trans rs13046373 0.905 rs4816372 chr21:32077414 A/T cg05790658 chr4:143748032 INPP4B -0.37 -5.98 -0.31 5.89e-9 HDL cholesterol; CRC cis rs9611565 0.659 rs12484694 chr22:41919330 A/G cg06634786 chr22:41940651 POLR3H -0.66 -7.7 -0.39 1.64e-13 Vitiligo; CRC cis rs2836950 0.585 rs1029004 chr21:40615343 A/G cg17971929 chr21:40555470 PSMG1 -0.58 -8.46 -0.42 8.99e-16 Menarche (age at onset); CRC cis rs6701037 0.875 rs6929 chr1:175126721 A/G cg00321850 chr1:175162397 KIAA0040 -0.4 -6.47 -0.34 3.58e-10 Alcohol dependence; CRC cis rs6831352 0.838 rs2851250 chr4:100044113 G/C cg12011299 chr4:100065546 ADH4 0.49 9.28 0.46 2.34e-18 Alcohol dependence; CRC cis rs853679 0.517 rs35512245 chr6:28079953 T/C cg18032046 chr6:28092343 ZSCAN16 -0.52 -6.02 -0.32 4.59e-9 Depression; CRC cis rs7927592 0.913 rs3824850 chr11:68341873 A/G cg16797656 chr11:68205561 LRP5 0.36 5.73 0.3 2.27e-8 Total body bone mineral density; CRC cis rs9788333 0.962 rs34853044 chr13:21883784 C/T cg25811766 chr13:21894605 NA 0.6 9.03 0.45 1.47e-17 Thiazide-induced adverse metabolic effects in hypertensive patients; CRC trans rs1728785 1.000 rs1728780 chr16:68567642 G/C cg04657470 chr2:198365150 HSPE1;HSPD1 0.58 6.97 0.36 1.72e-11 Ulcerative colitis; CRC cis rs25422 0.887 rs9481844 chr6:118990941 G/A cg01339444 chr6:118972232 C6orf204 0.5 6.12 0.32 2.72e-9 Renal cell carcinoma; CRC cis rs2758596 1.000 rs2842866 chr1:156159721 G/A cg24450063 chr1:156163899 SLC25A44 0.76 6.91 0.36 2.55e-11 Paclitaxel disposition in epithelial ovarian cancer; CRC trans rs208520 0.909 rs58958359 chr6:67021381 A/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.83 9.86 0.48 2.82e-20 Exhaled nitric oxide output; CRC cis rs6502050 0.835 rs8073645 chr17:80110957 C/T cg25804541 chr17:80189381 SLC16A3 -0.31 -5.97 -0.31 6.08e-9 Life satisfaction; CRC cis rs10504229 0.683 rs113492050 chr8:58130046 A/G cg05313129 chr8:58192883 C8orf71 -0.43 -6.11 -0.32 2.74e-9 Developmental language disorder (linguistic errors); CRC cis rs6502050 0.871 rs8080366 chr17:80067298 A/G cg02741985 chr17:80059408 CCDC57 -0.44 -7.01 -0.36 1.37e-11 Life satisfaction; CRC cis rs9322193 0.962 rs10872656 chr6:150120580 A/C cg05861140 chr6:150128134 PCMT1 -0.42 -6.76 -0.35 6.48e-11 Lung cancer; CRC cis rs13217239 0.646 rs12209886 chr6:26984757 G/A cg05192639 chr6:26864778 GUSBL1 0.31 6.01 0.31 5.05e-9 Schizophrenia; CRC trans rs12639288 0.962 rs12638639 chr3:167660757 C/T cg23392782 chr16:88772647 RNF166;CTU2 -0.53 -6.26 -0.33 1.21e-9 Hirschsprung disease; CRC cis rs2839186 0.605 rs2839173 chr21:47676711 G/A cg09417038 chr21:47716443 C21orf57 -0.38 -6.24 -0.33 1.36e-9 Testicular germ cell tumor; CRC cis rs763121 0.853 rs138716 chr22:39146527 C/T cg06022373 chr22:39101656 GTPBP1 0.8 11.82 0.55 4.31e-27 Menopause (age at onset); CRC cis rs4285028 0.747 rs1574133 chr3:121468794 G/C cg20356878 chr3:121714668 ILDR1 -0.42 -5.94 -0.31 7.35e-9 Multiple sclerosis; CRC cis rs9894429 1.000 rs12948099 chr17:79600799 C/G cg21028142 chr17:79581711 NPLOC4 0.38 8.35 0.42 1.89e-15 Eye color traits; CRC trans rs17685 0.712 rs60232511 chr7:75800082 A/G cg19862616 chr7:65841803 NCRNA00174 0.99 17.36 0.69 2.15e-48 Coffee consumption;Coffee consumption (cups per day); CRC cis rs2239547 0.563 rs6797399 chr3:52905917 G/A cg18404041 chr3:52824283 ITIH1 -0.38 -7.03 -0.36 1.17e-11 Schizophrenia; CRC cis rs7586879 0.616 rs876186 chr2:25125585 C/T cg22495460 chr2:25135724 ADCY3 -0.87 -17.16 -0.69 1.4e-47 Body mass index; CRC trans rs11098499 0.730 rs12505735 chr4:120532956 G/T cg25214090 chr10:38739885 LOC399744 0.67 10.43 0.5 3.39e-22 Corneal astigmatism; CRC cis rs7044106 0.708 rs920745 chr9:123429943 T/C cg09419670 chr9:123605666 PSMD5;LOC253039 0.7 11.44 0.53 9.85e-26 Hip circumference adjusted for BMI; CRC cis rs10752881 0.935 rs4652771 chr1:183023503 G/A ch.1.3577855R chr1:183094577 LAMC1 0.83 14.62 0.63 1.22e-37 Colorectal cancer; CRC cis rs10504229 0.683 rs7816733 chr8:58129855 G/A cg02725872 chr8:58115012 NA -0.64 -11.55 -0.54 3.85e-26 Developmental language disorder (linguistic errors); CRC cis rs6502050 0.835 rs8077926 chr17:80117315 C/A cg25804541 chr17:80189381 SLC16A3 -0.3 -5.88 -0.31 9.84e-9 Life satisfaction; CRC cis rs4363385 0.747 rs2339493 chr1:152975277 G/A cg25856811 chr1:152973957 SPRR3 -0.25 -6.76 -0.35 6.27e-11 Inflammatory skin disease; CRC cis rs6502050 0.835 rs9902485 chr17:80093701 C/T cg22110888 chr17:80059540 CCDC57 0.4 6.41 0.33 5.11e-10 Life satisfaction; CRC cis rs10256972 0.552 rs2949195 chr7:1202705 G/A cg23708337 chr7:1209742 NA 0.5 7.67 0.39 2.02e-13 Longevity;Endometriosis; CRC cis rs62064224 0.714 rs4794917 chr17:30636146 C/G cg25809561 chr17:30822961 MYO1D 0.52 9.43 0.46 7.81e-19 Schizophrenia; CRC cis rs7584330 0.554 rs7598559 chr2:238435398 A/G cg14458575 chr2:238380390 NA -0.54 -7.08 -0.36 8.7e-12 Prostate cancer; CRC cis rs2421770 0.530 rs7930134 chr11:35367017 A/C cg13971030 chr11:35366721 SLC1A2 -0.38 -6.68 -0.35 1.05e-10 Staphylococcus aureus nasal carriage (persistent); CRC cis rs853679 0.713 rs200991 chr6:27815494 A/C cg02683197 chr6:28174875 NA -0.55 -5.86 -0.31 1.13e-8 Depression; CRC cis rs7804356 0.953 rs73069539 chr7:26903661 C/T cg03456212 chr7:26904342 SKAP2 -0.53 -5.93 -0.31 7.6e-9 Type 1 diabetes; CRC cis rs10883723 0.810 rs6584504 chr10:104253507 T/C cg22532475 chr10:104410764 TRIM8 -0.37 -6.86 -0.35 3.51e-11 Allergic disease (asthma, hay fever or eczema); CRC cis rs9733 0.596 rs2867301 chr1:150653795 C/T cg10589385 chr1:150898437 SETDB1 0.28 5.98 0.31 5.86e-9 Tonsillectomy; CRC cis rs1691799 0.867 rs1168341 chr12:66759080 G/C cg16791601 chr12:66731901 HELB -0.73 -12.82 -0.58 8.7e-31 White blood cell count (basophil); CRC cis rs282587 0.569 rs415552 chr13:113407564 A/C cg04656015 chr13:113407548 ATP11A 0.62 7.97 0.4 2.63e-14 Glycated hemoglobin levels; CRC trans rs2303319 0.504 rs56009150 chr2:162598582 T/C cg20397358 chr22:38597902 MAFF -0.71 -6.17 -0.32 2.03e-9 Cognitive function; CRC cis rs2739330 0.828 rs5751770 chr22:24252842 A/G cg18538332 chr22:24372958 LOC391322 -0.69 -10.75 -0.51 2.74e-23 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs875971 0.964 rs160635 chr7:65528918 T/C cg12463550 chr7:65579703 CRCP 0.48 6.81 0.35 4.7e-11 Aortic root size; CRC cis rs9747201 1.000 rs56051385 chr17:80126712 T/C cg09264619 chr17:80180166 NA 0.5 7.26 0.37 2.77e-12 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs9322193 0.923 rs12529698 chr6:149972087 G/A cg07701084 chr6:150067640 NUP43 0.6 8.96 0.44 2.55e-17 Lung cancer; CRC cis rs2281845 0.929 rs6413915 chr1:201091041 A/C cg24849736 chr1:201084428 NA -0.63 -12.04 -0.55 6.41e-28 Permanent tooth development; CRC trans rs1005277 0.579 rs2472176 chr10:38382921 T/C cg11292332 chr7:45801988 SEPT13 -0.35 -6.26 -0.33 1.23e-9 Extrinsic epigenetic age acceleration; CRC cis rs3008870 1.000 rs2755256 chr1:67471692 A/T cg08660285 chr1:67390436 MIER1;WDR78 1.01 14.69 0.63 6.35e-38 Lymphocyte percentage of white cells; CRC cis rs10046574 0.519 rs9656456 chr7:135202208 G/A cg27474649 chr7:135195673 CNOT4 0.67 6.29 0.33 9.88e-10 Peripheral arterial disease (traffic-related air pollution interaction); CRC trans rs3733585 0.673 rs7434391 chr4:9967682 C/G cg26043149 chr18:55253948 FECH -0.49 -7.51 -0.38 5.78e-13 Cleft plate (environmental tobacco smoke interaction); CRC cis rs9611565 0.659 rs73178641 chr22:41952075 A/T cg17554472 chr22:41940697 POLR3H -0.57 -6.08 -0.32 3.3e-9 Vitiligo; CRC cis rs270601 0.770 rs932019 chr5:131599370 T/C cg11843238 chr5:131593191 PDLIM4 0.5 9.48 0.46 5.25e-19 Acylcarnitine levels; CRC cis rs12701220 0.894 rs12701348 chr7:1039457 C/T cg26240231 chr7:1148101 C7orf50 -0.42 -5.99 -0.31 5.56e-9 Bronchopulmonary dysplasia; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg00867475 chr7:99746517 C7orf59 0.42 6.06 0.32 3.74e-9 Anxiety disorder; CRC trans rs1005277 0.579 rs2505198 chr10:38393183 A/C cg27523141 chr10:43048294 ZNF37B 0.49 7.38 0.38 1.32e-12 Extrinsic epigenetic age acceleration; CRC cis rs4481887 0.830 rs4474289 chr1:248474972 T/A cg00666640 chr1:248458726 OR2T12 0.44 7.49 0.38 6.24e-13 Common traits (Other); CRC cis rs12950390 0.853 rs56137679 chr17:45862112 C/G cg24803719 chr17:45855879 NA -0.32 -6.98 -0.36 1.63e-11 IgG glycosylation; CRC cis rs3093024 1.000 rs3093023 chr6:167534290 A/G cg07513332 chr6:167530253 CCR6 -0.38 -6.58 -0.34 1.82e-10 Rheumatoid arthritis; CRC cis rs896854 0.625 rs7823886 chr8:95986459 A/T cg09323728 chr8:95962352 TP53INP1 -0.46 -7.4 -0.38 1.15e-12 Type 2 diabetes; CRC trans rs1656966 1.000 rs1656966 chr3:186466252 C/T cg24666276 chr8:128748214 MYC 0.42 6.2 0.32 1.66e-9 Myopia (pathological); CRC cis rs4888262 0.564 rs8050850 chr16:74582597 C/A cg01733217 chr16:74700730 RFWD3 0.74 11.12 0.52 1.32e-24 Testicular germ cell tumor; CRC cis rs28735056 0.620 rs12456484 chr18:77677315 C/G cg20368463 chr18:77673604 PQLC1 0.67 10.92 0.52 6.75e-24 Schizophrenia; CRC cis rs67340775 0.541 rs200968 chr6:27859568 T/C cg02683197 chr6:28174875 NA 0.68 6.7 0.35 8.9e-11 Lung cancer in ever smokers; CRC cis rs1395 0.778 rs724311 chr2:27441645 A/G cg14242246 chr2:27434262 C2orf28;SLC5A6 0.42 7.82 0.4 7.25e-14 Blood metabolite levels; CRC cis rs7043114 0.507 rs2007837 chr9:95189767 A/T cg13798575 chr9:95087839 CENPP;NOL8 -0.4 -5.96 -0.31 6.43e-9 Height; CRC cis rs7666738 0.830 rs28417577 chr4:99053007 T/C cg05340658 chr4:99064831 C4orf37 0.6 9.35 0.46 1.4e-18 Colonoscopy-negative controls vs population controls; CRC cis rs3760982 0.585 rs8109478 chr19:44298256 C/T cg11993925 chr19:44307056 LYPD5 0.57 10.18 0.49 2.44e-21 Breast cancer (estrogen-receptor negative);Breast cancer; CRC cis rs3785574 0.962 rs57553639 chr17:61848499 C/T cg23090583 chr17:61904693 PSMC5;FTSJ3 0.65 9.52 0.46 3.78e-19 Height; CRC cis rs2243480 1.000 rs2533288 chr7:66056711 C/G cg25985355 chr7:65971099 NA -0.52 -5.9 -0.31 8.8e-9 Diabetic kidney disease; CRC cis rs2115630 0.645 rs3825878 chr15:85174755 C/T cg09876464 chr15:85330779 ZNF592 0.39 6.48 0.34 3.34e-10 P wave terminal force; CRC cis rs34034915 1 rs34034915 chr6:27720703 T/TG cg15845792 chr6:28175446 NA 0.58 8.25 0.41 3.8e-15 Hepatitis A; CRC cis rs9443645 0.869 rs2095724 chr6:79742101 C/T cg09184832 chr6:79620586 NA -0.51 -9.3 -0.46 2.01e-18 Intelligence (multi-trait analysis); CRC cis rs644799 0.965 rs499076 chr11:95546341 A/G cg03916912 chr11:95522834 CEP57;FAM76B 0.95 18.15 0.71 1.71e-51 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs7258465 1.000 rs8107367 chr19:18564705 A/G cg06462663 chr19:18546047 ISYNA1 0.48 7.21 0.37 3.97e-12 Breast cancer; CRC cis rs7552404 0.920 rs2788654 chr1:76219569 C/T cg03433033 chr1:76189801 ACADM 0.74 11.17 0.52 8.95e-25 Blood metabolite levels;Acylcarnitine levels; CRC cis rs6500602 0.627 rs9934267 chr16:4534366 G/C cg14951292 chr16:4525986 HMOX2;NMRAL1 0.72 10.3 0.49 9.14e-22 Schizophrenia; CRC cis rs514406 0.755 rs11206015 chr1:53242187 T/C cg25767906 chr1:53392781 SCP2 0.4 6.54 0.34 2.35e-10 Monocyte count; CRC cis rs501120 0.657 rs494207 chr10:44741256 G/A cg09554077 chr10:44749378 NA 0.83 10.78 0.51 2.11e-23 Coronary artery disease;Coronary heart disease; CRC cis rs736801 0.569 rs12517950 chr5:131731326 A/G cg00255919 chr5:131827918 IRF1 -0.35 -5.91 -0.31 8.6e-9 Breast cancer;Mosquito bite size; CRC cis rs4665809 1.000 rs6709595 chr2:26259885 A/G cg26119090 chr2:26468346 HADHA;HADHB -0.61 -7.96 -0.4 2.87e-14 Gut microbiome composition (summer); CRC trans rs875971 0.545 rs11766183 chr7:65839160 G/C cg02869306 chr7:64672164 INTS4L1 -0.43 -6.19 -0.32 1.82e-9 Aortic root size; CRC cis rs4073416 0.518 rs11158595 chr14:65906369 A/G cg03016385 chr14:66212404 NA -0.44 -5.99 -0.31 5.49e-9 N-glycan levels; CRC trans rs13046373 0.905 rs4816372 chr21:32077414 A/T cg11361335 chr5:153653483 GALNT10 -0.37 -6.04 -0.32 4.1e-9 HDL cholesterol; CRC cis rs1577917 0.740 rs2758843 chr6:86328431 A/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.55 -7.53 -0.38 4.9e-13 Response to antipsychotic treatment; CRC cis rs2836974 0.584 rs34436313 chr21:40685246 A/G cg06238570 chr21:40685208 BRWD1 -0.87 -13.87 -0.61 9.35e-35 Cognitive function; CRC trans rs916888 0.779 rs199528 chr17:44843136 C/T cg10053473 chr17:62856997 LRRC37A3 -0.82 -8.74 -0.43 1.18e-16 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC trans rs10504229 1.000 rs60651159 chr8:58174074 T/C cg04077850 chr5:125800366 GRAMD3 0.37 6.27 0.33 1.15e-9 Developmental language disorder (linguistic errors); CRC cis rs9611565 0.512 rs139566 chr22:42199277 A/G cg06481639 chr22:41940642 POLR3H -0.61 -6.88 -0.35 3.08e-11 Vitiligo; CRC cis rs17767392 0.958 rs2332641 chr14:72044728 T/G cg13720639 chr14:72061746 SIPA1L1 0.57 7.01 0.36 1.37e-11 Mitral valve prolapse; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg27194998 chr19:47217554 PRKD2 0.36 5.98 0.31 5.97e-9 Liver disease severity in Alagille syndrome; CRC cis rs617791 0.569 rs11227370 chr11:65747693 C/T cg27068330 chr11:65405492 SIPA1 -0.47 -6.55 -0.34 2.24e-10 Breast cancer; CRC cis rs7692995 0.920 rs1380294 chr4:18024121 C/T cg08925142 chr4:18023851 LCORL -0.51 -5.81 -0.3 1.5e-8 Height; CRC cis rs4132509 1.000 rs6660534 chr1:243791642 A/C cg21452805 chr1:244014465 NA 0.5 6.92 0.36 2.35e-11 RR interval (heart rate); CRC cis rs2075371 0.796 rs12672752 chr7:134007382 C/T cg11752832 chr7:134001865 SLC35B4 0.45 6.81 0.35 4.61e-11 Mean platelet volume; CRC cis rs4588572 0.643 rs10474554 chr5:77799158 C/T cg11547950 chr5:77652471 NA -0.53 -7.06 -0.36 1.01e-11 Triglycerides; CRC cis rs6951245 0.935 rs78573577 chr7:1089087 C/A cg26224354 chr7:1096374 C7orf50;GPR146 -0.94 -11.87 -0.55 2.79e-27 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs801193 1.000 rs2707856 chr7:66211010 A/T cg00343986 chr7:65444356 GUSB 0.49 7.27 0.37 2.71e-12 Aortic root size; CRC cis rs939574 0.790 rs72955447 chr2:220098287 G/A cg00496455 chr2:220118770 TUBA4A;TUBA4B 0.91 8.44 0.42 1.06e-15 Platelet distribution width; CRC cis rs9381040 0.610 rs717883 chr6:41045270 T/C cg03644281 chr6:41068752 NFYA;LOC221442 -0.43 -6.02 -0.32 4.63e-9 Alzheimer's disease (late onset); CRC cis rs1401999 0.510 rs12634398 chr3:183708405 A/G cg05044414 chr3:183734942 ABCC5 0.35 5.87 0.31 1.06e-8 Anterior chamber depth; CRC cis rs35110281 0.720 rs162400 chr21:44950305 A/C cg01579765 chr21:45077557 HSF2BP -0.36 -6.79 -0.35 5.37e-11 Mean corpuscular volume; CRC cis rs1448094 0.512 rs4362214 chr12:86245145 C/T cg19622623 chr12:86230825 RASSF9 -0.41 -6.7 -0.35 9.04e-11 Major depressive disorder; CRC cis rs12931792 0.782 rs12927190 chr16:30169393 C/G cg17640201 chr16:30407289 ZNF48 0.41 5.78 0.3 1.75e-8 Tonsillectomy; CRC cis rs769267 0.965 rs8101938 chr19:19390497 G/A cg02546618 chr19:19431379 KIAA0892;SF4 0.46 6.3 0.33 9.51e-10 Tonsillectomy; CRC cis rs853679 0.517 rs9468286 chr6:28079428 C/T cg23161317 chr6:28129485 ZNF389 0.54 6.56 0.34 2.12e-10 Depression; CRC cis rs6499255 0.904 rs10852458 chr16:69672410 G/A cg04110750 chr16:69646130 NFAT5 -0.49 -7.11 -0.37 7.06e-12 IgE levels; CRC cis rs17345786 0.511 rs1138818 chr3:101399583 C/G cg11279151 chr3:101281821 RG9MTD1 -0.57 -7.74 -0.39 1.25e-13 Colonoscopy-negative controls vs population controls; CRC cis rs1707322 0.721 rs7520123 chr1:46235219 C/G cg03146154 chr1:46216737 IPP 0.59 8.46 0.42 9.18e-16 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs4974559 0.501 rs1250096 chr4:1238836 G/C cg02980000 chr4:1222292 CTBP1 -0.73 -8.36 -0.42 1.76e-15 Systolic blood pressure; CRC cis rs13392177 0.660 rs62185964 chr2:219073745 A/G cg04880052 chr2:219191631 PNKD -0.39 -5.88 -0.31 1.03e-8 Pyoderma gangrenosum in inflammatory bowel disease; CRC cis rs875971 0.862 rs13536 chr7:66019190 G/A cg11764359 chr7:65958608 NA -0.59 -8.81 -0.44 7.57e-17 Aortic root size; CRC cis rs929596 0.563 rs1105879 chr2:234602202 A/C cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.48 -7.34 -0.38 1.63e-12 Total bilirubin levels in HIV-1 infection; CRC cis rs10791323 0.660 rs10791332 chr11:133732150 A/G cg06766960 chr11:133703094 NA -0.4 -7.21 -0.37 3.78e-12 Childhood ear infection; CRC cis rs1348850 0.632 rs13009207 chr2:178501632 A/G cg02961200 chr2:178257176 LOC100130691;AGPS 0.61 8.67 0.43 2.05e-16 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs2421770 0.530 rs4756217 chr11:35366733 C/T cg13971030 chr11:35366721 SLC1A2 -0.38 -6.68 -0.35 1.05e-10 Staphylococcus aureus nasal carriage (persistent); CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg12149777 chr4:139937459 CCRN4L 0.37 5.97 0.31 6.08e-9 Obesity-related traits; CRC trans rs9858542 1.000 rs1131095 chr3:49714225 T/C cg21659725 chr3:3221576 CRBN -0.68 -8.92 -0.44 3.4e-17 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs7666738 0.783 rs10028584 chr4:98962404 C/T cg05340658 chr4:99064831 C4orf37 0.61 9.32 0.46 1.68e-18 Colonoscopy-negative controls vs population controls; CRC cis rs853679 0.517 rs9380057 chr6:28104634 G/T cg18032046 chr6:28092343 ZSCAN16 -0.52 -6.08 -0.32 3.3e-9 Depression; CRC cis rs10911251 0.546 rs2147578 chr1:183107699 G/C ch.1.3577855R chr1:183094577 LAMC1 0.82 14.03 0.61 2.24e-35 Colorectal cancer; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg03552687 chr12:94071294 CRADD 0.42 6.02 0.31 4.64e-9 Intelligence (multi-trait analysis); CRC cis rs4466137 0.830 rs10039752 chr5:82974532 G/A cg15083037 chr5:83017644 HAPLN1 -0.46 -6.38 -0.33 6.15e-10 Prostate cancer; CRC cis rs561341 0.941 rs550213 chr17:30317518 C/G cg19193384 chr17:30244184 NA -0.53 -6.73 -0.35 7.6e-11 Hip circumference adjusted for BMI; CRC cis rs9436116 1 rs9436116 chr1:150454724 G/T cg15654264 chr1:150340011 RPRD2 0.4 5.91 0.31 8.38e-9 Morning vs. evening chronotype; CRC cis rs12477438 0.520 rs720229 chr2:99704273 T/C cg26064155 chr2:99771622 LIPT1;TSGA10 0.79 13.61 0.6 9.4e-34 Chronic sinus infection; CRC cis rs28386778 0.897 rs6504187 chr17:61917099 G/A cg22520471 chr17:61851767 DDX42;CCDC47 0.75 11.67 0.54 1.44e-26 Prudent dietary pattern; CRC cis rs595982 0.559 rs17206714 chr19:49362001 T/A cg15549821 chr19:49342101 PLEKHA4 -0.58 -6.74 -0.35 7.1e-11 Red cell distribution width; CRC cis rs12422267 0.609 rs11246940 chr12:132623473 A/G cg09764611 chr12:132620959 NA -0.63 -8.52 -0.43 5.71e-16 Plasma amyloid beta peptide concentrations (ABx-40); CRC cis rs7677751 0.806 rs4864860 chr4:55090021 T/C cg00691999 chr4:55094011 PDGFRA 0.44 6.46 0.34 3.74e-10 Corneal astigmatism; CRC trans rs3942852 0.806 rs10769317 chr11:48150712 T/C cg15704280 chr7:45808275 SEPT13 -0.6 -7.58 -0.39 3.65e-13 Acute lymphoblastic leukemia (childhood); CRC cis rs2635047 0.811 rs12958943 chr18:44786818 T/C cg19077165 chr18:44547161 KATNAL2 -0.39 -5.94 -0.31 7.29e-9 Educational attainment; CRC cis rs7605827 0.930 rs2058867 chr2:15520153 T/C cg19274914 chr2:15703543 NA 0.39 5.87 0.31 1.05e-8 Educational attainment (years of education); CRC cis rs10504229 0.683 rs16921807 chr8:58105967 C/T cg05313129 chr8:58192883 C8orf71 -0.43 -5.87 -0.31 1.09e-8 Developmental language disorder (linguistic errors); CRC cis rs2980439 0.525 rs2980508 chr8:8171732 C/T cg08975724 chr8:8085496 FLJ10661 0.39 6.09 0.32 3.22e-9 Neuroticism; CRC cis rs7208859 0.623 rs56095789 chr17:29060170 A/G cg01831904 chr17:28903510 LRRC37B2 -0.61 -6.22 -0.32 1.52e-9 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs10504229 0.683 rs34859456 chr8:58117722 A/C cg05313129 chr8:58192883 C8orf71 -0.43 -6.11 -0.32 2.74e-9 Developmental language disorder (linguistic errors); CRC cis rs1552244 1.000 rs6442148 chr3:10078289 G/C cg10729496 chr3:10149963 C3orf24 0.5 6.81 0.35 4.65e-11 Alzheimer's disease; CRC cis rs8180040 0.701 rs1079276 chr3:47045739 C/G cg10298567 chr3:47292165 KIF9 -0.38 -6.17 -0.32 1.99e-9 Colorectal cancer; CRC cis rs9287719 0.624 rs10172926 chr2:10733254 A/C cg00105475 chr2:10696890 NA 0.44 7.0 0.36 1.43e-11 Prostate cancer; CRC cis rs11148252 0.712 rs61957257 chr13:52769702 G/A cg12458913 chr13:53173898 NA 0.54 8.53 0.43 5.32e-16 Lewy body disease; CRC cis rs1005277 0.579 rs1740742 chr10:38518860 C/T cg25427524 chr10:38739819 LOC399744 -0.79 -14.49 -0.62 3.78e-37 Extrinsic epigenetic age acceleration; CRC cis rs600806 0.850 rs1465607 chr1:109958035 T/C cg23032129 chr1:109941072 SORT1 -0.28 -5.94 -0.31 7.09e-9 Intelligence (multi-trait analysis); CRC cis rs7666738 0.830 rs11725477 chr4:98803266 G/T cg05340658 chr4:99064831 C4orf37 0.56 7.98 0.4 2.47e-14 Colonoscopy-negative controls vs population controls; CRC cis rs7829975 0.659 rs4382480 chr8:8721473 C/T cg08975724 chr8:8085496 FLJ10661 0.4 6.06 0.32 3.74e-9 Mood instability; CRC cis rs6951245 0.706 rs28522260 chr7:1183964 C/A cg22907277 chr7:1156413 C7orf50 0.76 8.49 0.42 7.07e-16 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs4332037 0.624 rs11764124 chr7:1891723 C/G cg25834613 chr7:1915315 MAD1L1 -0.4 -6.14 -0.32 2.32e-9 Bipolar disorder; CRC trans rs9650657 0.529 rs10108618 chr8:10953092 A/G cg06636001 chr8:8085503 FLJ10661 -0.65 -10.4 -0.5 4.18e-22 Neuroticism; CRC cis rs427943 0.750 rs9974232 chr21:46617587 A/G cg19498844 chr21:46707878 POFUT2;LOC642852 0.45 6.02 0.32 4.53e-9 Body mass index; CRC trans rs208515 0.525 rs10498841 chr6:66663706 C/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.9 11.5 0.54 5.82e-26 Exhaled nitric oxide levels; CRC trans rs1945213 0.694 rs7131381 chr11:55858158 T/G cg03929089 chr4:120376271 NA 0.59 6.66 0.34 1.17e-10 Acute lymphoblastic leukemia (childhood); CRC cis rs394563 0.622 rs237024 chr6:149721965 T/C cg16235748 chr6:149772707 ZC3H12D -0.39 -7.01 -0.36 1.37e-11 Dupuytren's disease; CRC cis rs6502050 0.764 rs28676462 chr17:80105100 G/C cg13198984 chr17:80129470 CCDC57 0.46 8.16 0.41 6.94e-15 Life satisfaction; CRC cis rs6951245 1.000 rs1997243 chr7:1083777 A/G cg18402987 chr7:1209562 NA 0.64 6.78 0.35 5.48e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs9905704 0.846 rs28363318 chr17:56798207 T/C cg12560992 chr17:57184187 TRIM37 0.54 7.92 0.4 3.75e-14 Testicular germ cell tumor; CRC cis rs2204008 0.720 rs11170774 chr12:38021722 C/T cg26384229 chr12:38710491 ALG10B -0.64 -9.89 -0.48 2.26e-20 Bladder cancer; CRC cis rs11212617 0.967 rs4754324 chr11:108325448 G/A cg14761454 chr11:108092087 ATM;NPAT 0.39 5.67 0.3 3.09e-8 Response to metformin in type 2 diabetes (glycemic); CRC cis rs1046896 0.594 rs9914570 chr17:80783721 C/T cg16060761 chr17:80687452 NA -0.45 -5.8 -0.3 1.52e-8 Glycated hemoglobin levels; CRC cis rs10751667 0.643 rs7396407 chr11:929374 A/T ch.11.42038R chr11:967971 AP2A2 0.6 10.22 0.49 1.74e-21 Alzheimer's disease (late onset); CRC cis rs9522267 0.737 rs9515448 chr13:112229526 A/T cg10483660 chr13:112241077 NA -0.4 -7.13 -0.37 6.37e-12 Hepatitis; CRC cis rs7208859 0.614 rs216412 chr17:28903394 A/G cg14008862 chr17:28927542 LRRC37B2 -0.52 -6.58 -0.34 1.84e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs2239547 0.657 rs7620706 chr3:52891756 A/T cg11645453 chr3:52864694 ITIH4 0.61 10.71 0.51 3.56e-23 Schizophrenia; CRC cis rs4243830 1.000 rs12047931 chr1:6587614 C/T cg22792644 chr1:6614718 TAS1R1;NOL9 0.77 6.28 0.33 1.05e-9 Body mass index; CRC trans rs1005277 0.540 rs2474598 chr10:38430296 C/T cg27523141 chr10:43048294 ZNF37B -0.48 -6.85 -0.35 3.72e-11 Extrinsic epigenetic age acceleration; CRC cis rs10876993 0.890 rs2619441 chr12:58083015 C/A cg15848620 chr12:58087721 OS9 -0.65 -9.11 -0.45 7.98e-18 Celiac disease or Rheumatoid arthritis; CRC cis rs4819052 0.851 rs4818768 chr21:46659818 T/A cg11663144 chr21:46675770 NA -0.83 -14.12 -0.61 9.88e-36 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs12594515 1.000 rs58368732 chr15:45990531 G/C cg22117107 chr15:45993392 NA -0.44 -9.09 -0.45 9.56e-18 Waist circumference;Weight; CRC cis rs561341 1.000 rs8073186 chr17:30244956 T/C cg12193833 chr17:30244370 NA -0.58 -7.81 -0.4 7.78e-14 Hip circumference adjusted for BMI; CRC cis rs561341 0.783 rs512698 chr17:30292507 G/T cg23018236 chr17:30244563 NA -0.65 -7.78 -0.39 9.41e-14 Hip circumference adjusted for BMI; CRC cis rs7493 1.000 rs17876123 chr7:95045307 C/A cg01874867 chr7:94954059 PON1 -0.51 -6.42 -0.33 4.74e-10 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs853679 1.000 rs853676 chr6:28299687 C/T cg15845792 chr6:28175446 NA 0.58 5.82 0.31 1.4e-8 Depression; CRC cis rs26868 0.742 rs26848 chr16:2263516 A/G cg07587117 chr16:2239488 CASKIN1 0.49 9.24 0.45 3.12e-18 Height; CRC cis rs4862750 0.872 rs7679956 chr4:187900229 C/T cg11301795 chr4:187892539 NA -0.89 -21.06 -0.76 5.88e-63 Lobe attachment (rater-scored or self-reported); CRC cis rs4561483 0.798 rs456325 chr16:12012562 C/G cg08843971 chr16:11963173 GSPT1 -0.63 -8.94 -0.44 2.82e-17 Testicular germ cell tumor; CRC cis rs7246657 0.943 rs2291004 chr19:37997952 C/A cg23950597 chr19:37808831 NA -0.53 -6.18 -0.32 1.86e-9 Coronary artery calcification; CRC trans rs1005277 0.579 rs2021649 chr10:38392122 C/T cg27523141 chr10:43048294 ZNF37B 0.5 7.22 0.37 3.55e-12 Extrinsic epigenetic age acceleration; CRC cis rs736408 0.608 rs35004449 chr3:52852897 G/T cg15147215 chr3:52552868 STAB1 -0.43 -6.09 -0.32 3.17e-9 Bipolar disorder; CRC cis rs10504073 0.584 rs4873300 chr8:49902201 C/G cg00325661 chr8:49890786 NA 0.64 11.52 0.54 5.1e-26 Blood metabolite ratios; CRC cis rs875971 0.965 rs28682868 chr7:65689809 C/T cg18876405 chr7:65276391 NA -0.54 -9.31 -0.46 1.84e-18 Aortic root size; CRC cis rs9487051 0.872 rs9487034 chr6:109605899 A/G cg01475377 chr6:109611718 NA -0.49 -9.2 -0.45 4.27e-18 Reticulocyte fraction of red cells; CRC cis rs600231 0.508 rs17146964 chr11:65249145 C/T cg17120908 chr11:65337727 SSSCA1 0.7 7.79 0.39 8.59e-14 Bone mineral density; CRC cis rs9527 0.590 rs10786738 chr10:104869451 C/T cg15744005 chr10:104629667 AS3MT -0.31 -6.12 -0.32 2.69e-9 Arsenic metabolism; CRC cis rs3751196 0.521 rs17034637 chr12:104217600 A/C cg02344784 chr12:104178138 NT5DC3 -0.7 -7.29 -0.37 2.29e-12 Sense of smell; CRC cis rs311392 0.867 rs364484 chr8:55093492 G/T cg06042504 chr8:55087323 NA -0.44 -6.82 -0.35 4.41e-11 Pelvic organ prolapse (moderate/severe); CRC cis rs35000415 0.938 rs17424602 chr7:128687940 A/G cg19972273 chr7:128594194 NA 0.72 6.27 0.33 1.16e-9 Systemic lupus erythematosus; CRC cis rs7945718 0.650 rs4316494 chr11:12664541 C/T cg25843174 chr11:12811716 TEAD1 -0.42 -7.65 -0.39 2.2e-13 Educational attainment (years of education); CRC cis rs7772486 0.720 rs6931553 chr6:146112348 T/C cg05347473 chr6:146136440 FBXO30 -0.38 -5.72 -0.3 2.36e-8 Lobe attachment (rater-scored or self-reported); CRC cis rs651907 0.535 rs35799195 chr3:101521927 A/G cg11279151 chr3:101281821 RG9MTD1 -0.53 -7.09 -0.36 8.3e-12 Colorectal cancer; CRC cis rs7605827 0.897 rs7590963 chr2:15527888 T/C cg19274914 chr2:15703543 NA 0.39 5.92 0.31 7.9e-9 Educational attainment (years of education); CRC cis rs7666738 0.830 rs7667796 chr4:99071415 G/T cg05340658 chr4:99064831 C4orf37 -0.62 -9.51 -0.46 4.31e-19 Colonoscopy-negative controls vs population controls; CRC cis rs763014 0.966 rs4984677 chr16:671682 A/G cg09263875 chr16:632152 PIGQ 0.8 12.86 0.58 6.31e-31 Height; CRC cis rs12142240 0.698 rs72885198 chr1:46812888 C/T cg14993813 chr1:46806288 NSUN4 -0.51 -6.48 -0.34 3.28e-10 Menopause (age at onset); CRC cis rs270601 0.955 rs273911 chr5:131661526 C/G cg12564285 chr5:131593104 PDLIM4 0.45 7.58 0.39 3.59e-13 Acylcarnitine levels; CRC cis rs8060686 0.545 rs10500543 chr16:68281311 T/C cg26727032 chr16:67993705 SLC12A4 -0.62 -6.52 -0.34 2.61e-10 HDL cholesterol;Metabolic syndrome; CRC trans rs3008870 0.583 rs11208985 chr1:67464666 G/A cg01448155 chr10:3564782 NA 0.52 6.22 0.32 1.5e-9 Lymphocyte percentage of white cells; CRC cis rs753955 0.554 rs2031587 chr13:24417335 A/G cg25267304 chr13:24462978 PCOTH;MIPEP 0.39 5.83 0.31 1.33e-8 Lung cancer; CRC cis rs9611565 0.694 rs202622 chr22:41825342 T/G cg06634786 chr22:41940651 POLR3H 0.72 8.0 0.4 2.21e-14 Vitiligo; CRC cis rs2576037 0.899 rs2246877 chr18:44577005 A/G cg19077165 chr18:44547161 KATNAL2 0.46 6.74 0.35 7.31e-11 Personality dimensions; CRC trans rs1814175 0.745 rs7483456 chr11:49774613 C/T cg03929089 chr4:120376271 NA -0.97 -19.26 -0.73 6.71e-56 Height; CRC trans rs2840044 1.000 rs2840044 chr17:33892068 A/G cg19694781 chr19:47549865 TMEM160 0.45 7.25 0.37 3.03e-12 Response to radiotherapy in cancer (late toxicity); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg10778407 chr1:6306850 NA 0.43 6.59 0.34 1.76e-10 Intelligence (multi-trait analysis); CRC cis rs4481887 0.927 rs11204631 chr1:248479530 A/G cg00666640 chr1:248458726 OR2T12 0.48 8.18 0.41 6.14e-15 Common traits (Other); CRC cis rs4319547 0.695 rs55834409 chr12:122862560 C/G cg05707623 chr12:122985044 ZCCHC8 0.75 9.08 0.45 1.03e-17 Body mass index; CRC cis rs875971 0.862 rs35034167 chr7:65580166 C/G cg11764359 chr7:65958608 NA -0.58 -9.08 -0.45 1.04e-17 Aortic root size; CRC cis rs6840360 0.904 rs6825241 chr4:152543783 C/A cg09659197 chr4:152720779 NA 0.37 7.43 0.38 9.2e-13 Intelligence (multi-trait analysis); CRC cis rs4073416 0.542 rs9323461 chr14:66031405 T/C cg03016385 chr14:66212404 NA -0.45 -6.19 -0.32 1.78e-9 N-glycan levels; CRC cis rs9393692 0.557 rs1883213 chr6:26303178 A/C cg00631329 chr6:26305371 NA -0.54 -9.0 -0.44 1.83e-17 Educational attainment; CRC trans rs7647973 0.588 rs62262675 chr3:49673662 A/G cg21665057 chr3:196295764 WDR53;FBXO45 0.6 6.12 0.32 2.71e-9 Menarche (age at onset); CRC cis rs4253772 0.720 rs4253778 chr22:46630634 C/G cg09491104 chr22:46646882 C22orf40 -0.42 -6.82 -0.35 4.48e-11 LDL cholesterol;Cholesterol, total; CRC cis rs17376456 0.778 rs72786662 chr5:93137630 C/T cg21475434 chr5:93447410 FAM172A 0.71 7.15 0.37 5.8e-12 Diabetic retinopathy; CRC trans rs35110281 0.776 rs1073522 chr21:45009219 T/A cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.54 9.23 0.45 3.27e-18 Mean corpuscular volume; CRC cis rs270601 0.710 rs4705852 chr5:131602807 A/G cg11843238 chr5:131593191 PDLIM4 0.49 9.31 0.46 1.86e-18 Acylcarnitine levels; CRC trans rs7613875 0.600 rs2856238 chr3:50158191 C/T cg21665057 chr3:196295764 WDR53;FBXO45 0.47 7.14 0.37 5.92e-12 Body mass index; CRC cis rs7659604 0.502 rs13106764 chr4:122699630 C/G cg19748678 chr4:122722346 EXOSC9 -0.44 -5.85 -0.31 1.16e-8 Type 2 diabetes; CRC cis rs2204008 0.811 rs12368410 chr12:38305705 C/T cg13010199 chr12:38710504 ALG10B 0.44 5.63 0.3 3.88e-8 Bladder cancer; CRC cis rs9875589 0.509 rs6775534 chr3:14051001 C/T cg14375111 chr3:14165186 TMEM43;CHCHD4 0.38 5.89 0.31 9.33e-9 Ovarian reserve; CRC cis rs7811142 1.000 rs60478351 chr7:100089017 C/T cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.17 17.06 0.69 3.29e-47 Platelet count; CRC cis rs539096 0.624 rs11210892 chr1:44100084 A/G cg12908607 chr1:44402522 ARTN 0.39 6.77 0.35 5.91e-11 Intelligence (multi-trait analysis); CRC cis rs870825 0.587 rs7682995 chr4:185640684 G/A cg04058563 chr4:185651563 MLF1IP 0.73 9.54 0.47 3.32e-19 Blood protein levels; CRC cis rs9916302 0.571 rs28799952 chr17:37533056 C/T cg00129232 chr17:37814104 STARD3 0.57 7.04 0.36 1.14e-11 Glomerular filtration rate (creatinine); CRC cis rs4862750 0.957 rs2375916 chr4:187903923 A/G cg11301795 chr4:187892539 NA -0.9 -20.28 -0.75 7.02e-60 Lobe attachment (rater-scored or self-reported); CRC cis rs751728 0.664 rs12196293 chr6:33749151 A/G cg25922239 chr6:33757077 LEMD2 0.46 6.85 0.35 3.63e-11 Crohn's disease; CRC cis rs853679 0.517 rs4713141 chr6:28101678 G/C cg15845792 chr6:28175446 NA 1.01 13.54 0.6 1.59e-33 Depression; CRC cis rs9322193 0.962 rs3763162 chr6:150140810 A/G cg13206674 chr6:150067644 NUP43 -0.57 -8.02 -0.4 1.89e-14 Lung cancer; CRC cis rs780096 0.526 rs1647276 chr2:27688601 C/T cg02592271 chr2:27665507 KRTCAP3 -0.28 -6.58 -0.34 1.83e-10 Total body bone mineral density; CRC cis rs6988985 0.703 rs6988323 chr8:143946483 A/G cg10324643 chr8:143916377 GML 0.36 5.87 0.31 1.06e-8 Plasma androstenedione levels in resected early stage-receptor positive breast cancer; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg11344692 chr8:61429175 RAB2A 0.47 6.77 0.35 5.9e-11 Response to antipsychotic treatment; CRC cis rs1904096 0.513 rs2632405 chr4:95152215 T/G cg11021082 chr4:95130006 SMARCAD1 -0.6 -9.57 -0.47 2.74e-19 Type 2 diabetes; CRC cis rs7208859 0.573 rs11656121 chr17:29214043 A/G cg13385521 chr17:29058706 SUZ12P 0.64 7.72 0.39 1.39e-13 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs7617480 0.648 rs7653408 chr3:48972351 A/C cg20833759 chr3:49053208 WDR6;DALRD3 0.68 10.81 0.51 1.68e-23 Subjective well-being (multi-trait analysis);Menarche (age at onset); CRC cis rs10493773 0.775 rs12738010 chr1:86102575 A/C cg17807903 chr1:86174739 ZNHIT6 0.52 11.45 0.53 8.98e-26 Urate levels in overweight individuals; CRC cis rs9649213 0.593 rs7807455 chr7:97957622 C/A cg00277769 chr7:97922759 BAIAP2L1 -0.61 -10.59 -0.5 9.83e-23 Prostate cancer (SNP x SNP interaction); CRC cis rs4481887 0.893 rs7515080 chr1:248494073 A/G cg00666640 chr1:248458726 OR2T12 0.55 9.44 0.46 6.87e-19 Common traits (Other); CRC cis rs35306767 0.668 rs72760914 chr10:1070952 A/G cg20503657 chr10:835505 NA 0.66 8.78 0.44 9.36e-17 Eosinophil percentage of granulocytes; CRC cis rs4665809 1.000 rs2384321 chr2:26290054 A/G cg22920501 chr2:26401640 FAM59B -0.57 -7.37 -0.38 1.42e-12 Gut microbiome composition (summer); CRC cis rs911555 0.655 rs10141157 chr14:104018105 T/C cg24130564 chr14:104152367 KLC1 -0.53 -8.11 -0.41 1.01e-14 Intelligence (multi-trait analysis); CRC cis rs9894429 0.608 rs7406382 chr17:79597786 T/C cg09655341 chr17:79618100 PDE6G -0.36 -6.24 -0.33 1.31e-9 Eye color traits; CRC cis rs1552244 0.752 rs9867091 chr3:10043429 T/C cg08888203 chr3:10149979 C3orf24 0.61 8.51 0.42 6.11e-16 Alzheimer's disease; CRC cis rs17234274 0.644 rs10767018 chr11:23221897 G/T cg05245346 chr11:23248277 NA 0.35 5.75 0.3 2.02e-8 Cancer; CRC cis rs643506 1.000 rs612345 chr11:111639122 G/A cg09085632 chr11:111637200 PPP2R1B 0.5 6.38 0.33 6.1e-10 Breast cancer; CRC cis rs4690686 0.500 rs2168032 chr4:177272957 A/G cg17059388 chr4:177262070 NA 0.4 6.1 0.32 3.05e-9 Essential tremor; CRC cis rs11123610 0.520 rs35482526 chr2:3720707 C/G cg10645314 chr2:3704589 ALLC -0.69 -7.78 -0.39 9.55e-14 Response to inhaled corticosteroid treatment in asthma (change in FEV1); CRC cis rs7666738 0.830 rs11722272 chr4:99000839 C/T cg03676636 chr4:99064102 C4orf37 0.2 5.85 0.31 1.2e-8 Colonoscopy-negative controls vs population controls; CRC cis rs9522267 0.502 rs9522297 chr13:112234419 C/T cg14352298 chr13:112236639 NA 0.29 6.67 0.35 1.06e-10 Hepatitis; CRC cis rs7959452 0.535 rs2305641 chr12:69646914 C/T cg20891283 chr12:69753455 YEATS4 0.77 13.16 0.59 4.58e-32 Blood protein levels; CRC cis rs6502050 0.835 rs8080625 chr17:80115447 G/A cg25804541 chr17:80189381 SLC16A3 -0.3 -5.88 -0.31 9.83e-9 Life satisfaction; CRC cis rs11098499 0.954 rs7654587 chr4:120388406 C/T cg09307838 chr4:120376055 NA 0.71 10.92 0.52 6.75e-24 Corneal astigmatism; CRC cis rs7249142 0.597 rs759999 chr19:19281207 A/C cg12558012 chr19:19281197 LOC729991-MEF2B;MEF2B 0.56 8.72 0.43 1.36e-16 IgG glycosylation; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg12877462 chr4:100484858 RG9MTD2;MTTP 0.48 6.95 0.36 1.98e-11 Response to antipsychotic treatment; CRC cis rs6840360 0.642 rs10454251 chr4:152383962 A/G cg09659197 chr4:152720779 NA 0.33 6.47 0.34 3.6e-10 Intelligence (multi-trait analysis); CRC cis rs881375 0.967 rs758959 chr9:123676699 C/T cg00246817 chr9:123691163 NA -0.44 -5.6 -0.3 4.47e-8 Rheumatoid arthritis; CRC trans rs1814175 0.645 rs7119101 chr11:49955665 G/A cg03929089 chr4:120376271 NA -0.91 -16.17 -0.67 1.06e-43 Height; CRC cis rs447 0.806 rs12707617 chr7:83745474 G/A cg22846510 chr7:83753280 SEMA3A -0.41 -5.7 -0.3 2.65e-8 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs6964587 1.000 rs2282971 chr7:91584356 A/G cg17063962 chr7:91808500 NA 0.79 14.22 0.62 4.13e-36 Breast cancer; CRC cis rs4713118 0.662 rs13218430 chr6:28029837 T/C cg23161317 chr6:28129485 ZNF389 0.44 5.76 0.3 1.96e-8 Parkinson's disease; CRC cis rs9747201 0.894 rs9944398 chr17:80177439 A/G cg14673194 chr17:80132900 CCDC57 -0.48 -6.02 -0.32 4.56e-9 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs2239547 0.522 rs2581815 chr3:52982159 C/G cg18404041 chr3:52824283 ITIH1 -0.33 -6.52 -0.34 2.72e-10 Schizophrenia; CRC cis rs2952156 0.920 rs732083 chr17:37834367 G/A cg00129232 chr17:37814104 STARD3 -0.7 -12.41 -0.56 2.85e-29 Asthma; CRC cis rs2346177 0.519 rs1597040 chr2:46673903 C/T cg02822958 chr2:46747628 ATP6V1E2 0.41 5.99 0.31 5.64e-9 HDL cholesterol; CRC trans rs3808502 0.516 rs6983727 chr8:11415812 A/G cg06636001 chr8:8085503 FLJ10661 0.47 7.31 0.37 2.06e-12 Neuroticism; CRC cis rs8077889 0.871 rs7212648 chr17:41917962 A/C cg25876840 chr17:41920477 NA 0.56 7.83 0.4 6.79e-14 Triglycerides; CRC cis rs6860806 0.507 rs270606 chr5:131650867 A/G cg11843238 chr5:131593191 PDLIM4 0.46 7.66 0.39 2.03e-13 Breast cancer; CRC cis rs7715806 0.500 rs17563589 chr5:74980019 A/G cg19683494 chr5:74908142 NA 0.55 6.16 0.32 2.1e-9 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs11098499 0.874 rs12509054 chr4:120115075 A/C cg24375607 chr4:120327624 NA 0.48 7.25 0.37 3.02e-12 Corneal astigmatism; CRC cis rs7666738 0.830 rs11941844 chr4:99042722 A/T cg05340658 chr4:99064831 C4orf37 0.6 9.35 0.46 1.36e-18 Colonoscopy-negative controls vs population controls; CRC cis rs938554 0.501 rs7671266 chr4:10056376 C/T cg00071950 chr4:10020882 SLC2A9 -0.54 -7.61 -0.39 2.89e-13 Blood metabolite levels; CRC cis rs13082711 0.558 rs1844983 chr3:27370203 C/T cg02860705 chr3:27208620 NA -0.54 -7.93 -0.4 3.4e-14 Systolic blood pressure;Diastolic blood pressure;Blood pressure; CRC cis rs2786111 0.965 rs1764788 chr1:197291306 A/G cg13682187 chr1:196946512 CFHR5 0.29 5.74 0.3 2.17e-8 Lupus nephritis in systemic lupus erythematosus; CRC cis rs1008375 1.000 rs13119927 chr4:17691640 G/A cg16339924 chr4:17578868 LAP3 -0.43 -5.66 -0.3 3.29e-8 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs4523957 0.579 rs57130712 chr17:2089035 A/G cg16513277 chr17:2031491 SMG6 -0.59 -9.86 -0.48 2.86e-20 Autism spectrum disorder or schizophrenia;Schizophrenia; CRC cis rs728616 0.614 rs61859210 chr10:82131468 G/C cg05935833 chr10:81318306 SFTPA2 -0.58 -7.02 -0.36 1.28e-11 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs8017423 0.647 rs12590712 chr14:90822481 T/C cg14092571 chr14:90743983 NA 0.38 5.92 0.31 8.07e-9 Mortality in heart failure; CRC cis rs9911578 0.835 rs9904993 chr17:56468569 G/T cg12560992 chr17:57184187 TRIM37 -0.83 -14.18 -0.62 5.91e-36 Intelligence (multi-trait analysis); CRC cis rs7552404 0.889 rs2211080 chr1:76243438 G/A cg03433033 chr1:76189801 ACADM 0.83 11.47 0.53 7.37e-26 Blood metabolite levels;Acylcarnitine levels; CRC cis rs6921919 0.583 rs9461456 chr6:28343816 A/G cg21251018 chr6:28226885 NKAPL 0.39 6.02 0.31 4.74e-9 Autism spectrum disorder or schizophrenia; CRC cis rs7772486 0.790 rs9376971 chr6:146259505 C/T cg23711669 chr6:146136114 FBXO30 -0.71 -12.51 -0.57 1.25e-29 Lobe attachment (rater-scored or self-reported); CRC cis rs951366 0.764 rs823143 chr1:205743425 A/C cg14159672 chr1:205819179 PM20D1 0.74 10.97 0.52 4.67e-24 Menarche (age at onset); CRC cis rs897984 0.760 rs11076 chr16:30995528 A/G cg00531865 chr16:30841666 NA 0.49 6.82 0.35 4.32e-11 Dementia with Lewy bodies; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg10681328 chr12:56915608 RBMS2 0.48 6.98 0.36 1.59e-11 Response to antipsychotic treatment; CRC cis rs10504229 1.000 rs67236942 chr8:58176525 T/C cg24829409 chr8:58192753 C8orf71 -0.68 -11.34 -0.53 2.27e-25 Developmental language disorder (linguistic errors); CRC cis rs1008375 0.931 rs10019482 chr4:17578079 G/A cg02297831 chr4:17616191 MED28 0.44 5.66 0.3 3.33e-8 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs7605378 1.000 rs7577763 chr2:200681753 C/T cg17644776 chr2:200775616 C2orf69 0.41 5.92 0.31 8.07e-9 Osteoporosis; CRC cis rs6951245 1.000 rs111899361 chr7:1112348 C/T cg20603222 chr7:1096387 C7orf50;GPR146 -0.73 -8.68 -0.43 1.83e-16 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs34435647 1 rs34435647 chr2:160518289 CT/C cg08347373 chr2:160653686 CD302 -0.38 -6.2 -0.32 1.72e-9 Granulocyte percentage of myeloid white cells;Neutrophil percentage of white cells; CRC cis rs2303759 0.515 rs2334867 chr19:49788205 C/T cg22590775 chr19:49891494 CCDC155 -0.46 -6.05 -0.32 3.95e-9 Multiple sclerosis; CRC cis rs10504229 0.728 rs77197419 chr8:58150879 C/A cg11062466 chr8:58055876 NA 0.45 6.11 0.32 2.74e-9 Developmental language disorder (linguistic errors); CRC cis rs4713118 0.866 rs2179094 chr6:27741825 T/C cg20933634 chr6:27740509 NA 0.64 8.97 0.44 2.38e-17 Parkinson's disease; CRC cis rs477692 0.905 rs485579 chr10:131425492 T/G cg05714579 chr10:131428358 MGMT 0.61 8.82 0.44 6.62e-17 Response to temozolomide; CRC cis rs3617 0.539 rs9825369 chr3:52953311 T/C cg11645453 chr3:52864694 ITIH4 -0.35 -6.64 -0.34 1.3e-10 Red blood cell count;Autism spectrum disorder or schizophrenia; CRC cis rs72781680 0.898 rs72788218 chr2:24090435 C/T cg08917208 chr2:24149416 ATAD2B 0.78 8.33 0.42 2.28e-15 Lymphocyte counts; CRC cis rs11212617 0.869 rs4754299 chr11:108025214 C/T cg12106634 chr11:108092400 ATM;NPAT 0.38 5.62 0.3 4.08e-8 Response to metformin in type 2 diabetes (glycemic); CRC cis rs3858526 0.920 rs11039698 chr11:5950907 C/T cg26762873 chr11:5879799 OR52E8 -0.4 -5.88 -0.31 1.01e-8 DNA methylation (variation); CRC cis rs3824867 0.920 rs7105907 chr11:47450318 A/T cg05585544 chr11:47624801 NA 0.41 6.23 0.33 1.4e-9 Mean corpuscular hemoglobin; CRC cis rs4478858 0.684 rs4949202 chr1:31736800 T/C cg00250761 chr1:31883323 NA -0.43 -8.38 -0.42 1.55e-15 Alcohol dependence; CRC cis rs9910055 0.659 rs3826412 chr17:42255097 A/G cg10896456 chr17:42255109 ASB16;C17orf65 0.52 9.28 0.46 2.38e-18 Total body bone mineral density; CRC cis rs2012796 0.785 rs61986599 chr14:81860917 G/A cg02996355 chr14:81879375 NA 0.63 9.55 0.47 3.07e-19 Night sleep phenotypes; CRC cis rs3749237 0.595 rs4855873 chr3:49459114 A/C cg07636037 chr3:49044803 WDR6 0.55 8.15 0.41 7.91e-15 Resting heart rate; CRC cis rs2243480 1.000 rs4718315 chr7:65648541 T/C cg18252515 chr7:66147081 NA 1.23 14.37 0.62 1.07e-36 Diabetic kidney disease; CRC cis rs769267 0.930 rs2301784 chr19:19390749 G/A cg20644253 chr19:19431407 KIAA0892;SF4 0.43 5.97 0.31 6e-9 Tonsillectomy; CRC cis rs12699477 0.545 rs117125814 chr7:1910681 T/G cg04267008 chr7:1944627 MAD1L1 -0.71 -10.98 -0.52 4.01e-24 Testicular germ cell tumor; CRC cis rs7552404 1.000 rs1498316 chr1:76159198 G/A cg10523679 chr1:76189770 ACADM 0.82 11.24 0.53 4.86e-25 Blood metabolite levels;Acylcarnitine levels; CRC cis rs4380275 1.000 rs4268954 chr2:772834 A/G cg27237671 chr2:676223 TMEM18 -0.42 -6.06 -0.32 3.69e-9 Adverse response to chemotherapy (neutropenia/leucopenia) (doxorubicin); CRC cis rs6141769 0.542 rs28542091 chr20:31301402 T/C cg13636640 chr20:31349939 DNMT3B -0.39 -5.84 -0.31 1.27e-8 Subjective well-being; CRC trans rs9329221 0.698 rs35388602 chr8:10259188 T/C cg06636001 chr8:8085503 FLJ10661 0.52 7.94 0.4 3.24e-14 Neuroticism; CRC cis rs9902453 0.726 rs3115092 chr17:28036350 C/T cg26525008 chr17:28256777 EFCAB5;SSH2 0.69 11.41 0.53 1.28e-25 Coffee consumption (cups per day); CRC trans rs4745661 0.564 rs1328523 chr9:80451693 C/A cg02160872 chr5:212506 CCDC127 0.37 5.98 0.31 5.69e-9 IgG glycosylation; CRC cis rs7945718 0.621 rs10765984 chr11:12672669 T/C cg25843174 chr11:12811716 TEAD1 0.4 7.15 0.37 5.65e-12 Educational attainment (years of education); CRC cis rs1670533 1.000 rs2045066 chr4:1052401 C/T cg27284194 chr4:1044797 NA 0.49 6.16 0.32 2.12e-9 Recombination rate (females); CRC cis rs910187 0.641 rs6124966 chr20:45813099 T/G cg27589058 chr20:45804311 EYA2 -0.4 -7.91 -0.4 3.86e-14 Migraine; CRC cis rs367615 0.704 rs7704824 chr5:108850278 A/G cg17395555 chr5:108820864 NA 0.31 6.22 0.32 1.51e-9 Colorectal cancer (SNP x SNP interaction); CRC trans rs9929218 1.000 rs2113201 chr16:68815000 C/T cg04657470 chr2:198365150 HSPE1;HSPD1 -0.84 -11.87 -0.55 2.74e-27 Colorectal cancer; CRC trans rs8073060 0.586 rs225265 chr17:33961972 C/T cg19694781 chr19:47549865 TMEM160 -1.05 -14.7 -0.63 5.76e-38 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; CRC cis rs270601 0.909 rs2569265 chr5:131704519 T/C cg24060327 chr5:131705240 SLC22A5 0.53 7.95 0.4 2.96e-14 Acylcarnitine levels; CRC trans rs1957429 0.520 rs12435626 chr14:65295215 A/G cg03748857 chr16:85658239 KIAA0182 -0.57 -6.13 -0.32 2.5e-9 Pediatric areal bone mineral density (radius); CRC cis rs7811142 0.830 rs6955367 chr7:99961194 A/G cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.7 10.0 0.48 9.68e-21 Platelet count; CRC cis rs875971 0.862 rs1083554 chr7:65852341 T/C cg00343986 chr7:65444356 GUSB 0.45 6.22 0.32 1.52e-9 Aortic root size; CRC cis rs4819052 0.851 rs28442024 chr21:46674475 C/A cg11663144 chr21:46675770 NA -0.81 -13.49 -0.6 2.52e-33 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs644799 0.710 rs519511 chr11:95538270 G/A cg25622487 chr11:95524042 FAM76B;CEP57 0.8 13.52 0.6 2.03e-33 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs4638749 0.677 rs115510885 chr2:108824365 C/T cg25838818 chr2:108905173 SULT1C2 -0.34 -5.71 -0.3 2.52e-8 Blood pressure; CRC cis rs73206853 0.764 rs7960705 chr12:111084540 G/A cg12870014 chr12:110450643 ANKRD13A 0.79 9.12 0.45 7.53e-18 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC cis rs10242455 0.557 rs73401516 chr7:99068351 C/A cg18809830 chr7:99032528 PTCD1 -1.07 -7.92 -0.4 3.8e-14 Blood metabolite levels; CRC cis rs6681460 0.837 rs6669023 chr1:67171868 G/T cg02459107 chr1:67143332 SGIP1 0.35 5.89 0.31 9.71e-9 Presence of antiphospholipid antibodies; CRC cis rs9811920 0.638 rs793461 chr3:99615758 C/T cg07805332 chr3:99536008 MIR548G;C3orf26 -0.51 -7.68 -0.39 1.84e-13 Axial length; CRC cis rs172166 0.694 rs1770131 chr6:28086413 C/T cg26587870 chr6:27730563 NA -0.39 -5.86 -0.31 1.13e-8 Cardiac Troponin-T levels; CRC trans rs629535 0.783 rs510632 chr8:70034570 A/G cg21567404 chr3:27674614 NA 0.95 16.08 0.66 2.35e-43 Dupuytren's disease; CRC cis rs2120019 0.567 rs28844983 chr15:75178088 T/A cg17294928 chr15:75287854 SCAMP5 -0.6 -6.99 -0.36 1.5e-11 Blood trace element (Zn levels); CRC cis rs826838 1.000 rs11168505 chr12:38939057 A/T cg26384229 chr12:38710491 ALG10B -0.7 -10.01 -0.48 9.18e-21 Heart rate; CRC cis rs9463078 0.625 rs679713 chr6:44899632 T/C cg25276700 chr6:44698697 NA -0.25 -6.09 -0.32 3.08e-9 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; CRC cis rs899997 1.000 rs11072793 chr15:79006442 C/T cg22753661 chr15:79092743 ADAMTS7 0.42 5.95 0.31 7.04e-9 Coronary artery disease or large artery stroke; CRC trans rs2228479 0.850 rs2190808 chr16:89840856 C/T cg24644049 chr4:85504048 CDS1 0.92 7.68 0.39 1.79e-13 Skin colour saturation; CRC cis rs9522267 0.535 rs914037 chr13:112235308 A/G cg10483660 chr13:112241077 NA -0.48 -9.0 -0.44 1.85e-17 Hepatitis; CRC cis rs62064224 0.553 rs9915115 chr17:30684858 A/G cg09324608 chr17:30823087 MYO1D 0.33 5.72 0.3 2.43e-8 Schizophrenia; CRC cis rs4588572 0.688 rs2115436 chr5:77692617 A/T cg11446398 chr5:77624930 NA 0.42 6.27 0.33 1.13e-9 Triglycerides; CRC cis rs9462846 0.691 rs9462853 chr6:42910666 T/C cg21280719 chr6:42927975 GNMT -0.33 -6.28 -0.33 1.06e-9 Blood protein levels; CRC cis rs13118159 0.573 rs7664763 chr4:1352305 A/G cg19318889 chr4:1322082 MAEA 0.68 10.0 0.48 9.98e-21 Longevity; CRC cis rs1348850 0.874 rs714598 chr2:178455311 T/A cg22681709 chr2:178499509 PDE11A -0.33 -6.07 -0.32 3.56e-9 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs12230513 0.732 rs60683621 chr12:55863224 C/G cg19537932 chr12:55886519 OR6C68 -0.72 -9.14 -0.45 6.52e-18 Contrast sensitivity; CRC cis rs9399135 0.660 rs4267967 chr6:135272477 T/G cg22676075 chr6:135203613 NA 0.5 7.68 0.39 1.82e-13 Red blood cell count; CRC cis rs1799949 1.000 rs4793194 chr17:41218333 G/A cg01879757 chr17:41196368 BRCA1 -0.44 -6.66 -0.34 1.15e-10 Menopause (age at onset); CRC cis rs9649213 0.593 rs11760930 chr7:97915789 G/A cg21770322 chr7:97807741 LMTK2 0.52 8.65 0.43 2.26e-16 Prostate cancer (SNP x SNP interaction); CRC cis rs12586317 0.576 rs2415265 chr14:35630388 A/G cg07166546 chr14:35805898 NA -0.28 -5.6 -0.3 4.45e-8 Psoriasis; CRC cis rs4713118 0.662 rs9380046 chr6:28030499 T/C cg25164649 chr6:28176230 NA 0.65 8.59 0.43 3.64e-16 Parkinson's disease; CRC cis rs826838 0.874 rs10880943 chr12:38734317 C/T cg13010199 chr12:38710504 ALG10B 0.48 6.38 0.33 6.11e-10 Heart rate; CRC trans rs926326 0.866 rs35785909 chr6:25511309 G/A cg25354657 chr11:129991445 APLP2 -0.42 -6.24 -0.33 1.31e-9 Platelet count; CRC cis rs11785400 0.928 rs10100287 chr8:143734836 C/T cg10596483 chr8:143751796 JRK 0.47 6.59 0.34 1.71e-10 Schizophrenia; CRC cis rs514406 0.621 rs1930306 chr1:53195686 C/G cg27535305 chr1:53392650 SCP2 0.34 6.04 0.32 4.09e-9 Monocyte count; CRC cis rs7542091 0.704 rs2142907 chr1:210039505 T/C cg22029157 chr1:209979665 IRF6 0.48 7.49 0.38 6.37e-13 Monobrow; CRC cis rs11252926 0.661 rs7077209 chr10:484159 A/G cg18196295 chr10:418757 DIP2C -0.51 -7.78 -0.39 9.47e-14 Psychosis in Alzheimer's disease; CRC cis rs898097 0.812 rs72859941 chr17:80837459 G/A cg03160526 chr17:80928410 B3GNTL1 -0.42 -6.07 -0.32 3.56e-9 Breast cancer; CRC cis rs6748734 1.000 rs11893118 chr2:241828308 C/G cg16358738 chr2:241808595 AGXT -0.37 -5.67 -0.3 3.19e-8 Urinary metabolites; CRC trans rs916888 0.773 rs538628 chr17:44787313 G/C cg23590916 chr17:43697445 MGC57346 0.72 7.15 0.37 5.58e-12 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs10504229 1.000 rs56168206 chr8:58184485 G/A cg05313129 chr8:58192883 C8orf71 -0.47 -6.99 -0.36 1.49e-11 Developmental language disorder (linguistic errors); CRC cis rs4919694 0.667 rs117927731 chr10:105112852 C/A cg04362960 chr10:104952993 NT5C2 0.85 7.93 0.4 3.47e-14 Arsenic metabolism; CRC trans rs3757458 0.546 rs73173757 chr7:101014265 A/G cg01200482 chr7:62514477 NA 0.75 6.06 0.32 3.81e-9 QT interval; CRC cis rs3617 0.625 rs6769789 chr3:52874446 C/T cg11645453 chr3:52864694 ITIH4 -0.46 -9.09 -0.45 9.35e-18 Red blood cell count;Autism spectrum disorder or schizophrenia; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg00269115 chr1:23695530 C1orf213;ZNF436 0.48 6.73 0.35 7.6e-11 Response to antipsychotic treatment; CRC trans rs1455244 0.700 rs7229302 chr18:11508904 G/T cg11854871 chr1:110881943 RBM15 0.39 6.01 0.31 4.86e-9 Schizophrenia; CRC cis rs10197940 0.662 rs10173699 chr2:152281561 C/G cg19508488 chr2:152266495 RIF1 -0.6 -8.56 -0.43 4.53e-16 Lung cancer; CRC cis rs6951245 1.000 rs78158942 chr7:1090440 G/T cg21664854 chr7:1097933 C7orf50;GPR146 0.78 8.73 0.43 1.29e-16 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs7586879 0.575 rs6712981 chr2:25126230 A/G cg22495460 chr2:25135724 ADCY3 -0.87 -16.95 -0.68 9.6e-47 Body mass index; CRC cis rs11229555 0.645 rs12269745 chr11:58176875 G/A cg15696309 chr11:58395628 NA -0.81 -10.45 -0.5 2.9e-22 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; CRC cis rs10986311 0.775 rs6478658 chr9:127127810 A/G cg14243010 chr9:127117328 LOC100129034;PSMB7 -0.39 -5.97 -0.31 6.11e-9 Vitiligo; CRC cis rs7811142 0.830 rs705866 chr7:99965285 T/C cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.71 8.96 0.44 2.41e-17 Platelet count; CRC cis rs10504229 0.683 rs11774585 chr8:58132685 G/A cg04204079 chr8:58130323 NA -0.45 -5.78 -0.3 1.71e-8 Developmental language disorder (linguistic errors); CRC cis rs4332037 0.624 rs11764337 chr7:1892309 A/G cg23378565 chr7:2036160 MAD1L1 0.4 6.09 0.32 3.21e-9 Bipolar disorder; CRC cis rs5769707 0.967 rs763127 chr22:50006078 C/T cg20744362 chr22:50050164 C22orf34 0.33 6.54 0.34 2.32e-10 Monocyte count;Monocyte percentage of white cells; CRC cis rs3106136 0.967 rs12643901 chr4:95145132 C/T cg11021082 chr4:95130006 SMARCAD1 -0.46 -7.18 -0.37 4.6e-12 Capecitabine sensitivity; CRC cis rs863345 0.604 rs11264976 chr1:158446927 G/A cg12129480 chr1:158549410 OR10X1 -0.29 -5.92 -0.31 8.16e-9 Pneumococcal bacteremia; CRC cis rs3858526 0.628 rs4237762 chr11:5956626 A/C cg13902645 chr11:5959945 NA -0.72 -11.82 -0.55 4.05e-27 DNA methylation (variation); CRC cis rs7618501 0.538 rs9856572 chr3:50109073 A/T cg24110177 chr3:50126178 RBM5 0.53 8.2 0.41 5.57e-15 Intelligence (multi-trait analysis); CRC cis rs3796352 1.000 rs11707780 chr3:53084326 A/G cg06204229 chr3:52865917 ITIH4 -0.42 -5.62 -0.3 4e-8 Immune reponse to smallpox (secreted IL-2); CRC cis rs7552404 0.727 rs7521344 chr1:76318325 C/T cg10523679 chr1:76189770 ACADM -0.68 -8.98 -0.44 2.09e-17 Blood metabolite levels;Acylcarnitine levels; CRC cis rs6460942 0.915 rs6968695 chr7:12443878 G/C cg06484146 chr7:12443880 VWDE -0.8 -8.59 -0.43 3.55e-16 Coronary artery disease; CRC trans rs2303319 0.504 rs56026147 chr2:162614089 T/C cg25193742 chr10:104614220 C10orf32 -0.77 -6.51 -0.34 2.87e-10 Cognitive function; CRC cis rs149866169 1 rs149866169 chr6:27441723 T/A cg26587870 chr6:27730563 NA -0.69 -6.4 -0.33 5.43e-10 Neuroticism (multi-trait analysis);Lung cancer in ever smokers;Subjective well-being (multi-trait analysis);Lung cancer;Squamous cell lung carcinoma; CRC cis rs2635047 0.615 rs9304343 chr18:44720664 C/T cg19077165 chr18:44547161 KATNAL2 -0.42 -6.2 -0.32 1.7e-9 Educational attainment; CRC cis rs1129187 0.719 rs3805953 chr6:42936900 C/T cg05552183 chr6:42928497 GNMT 0.53 7.94 0.4 3.33e-14 Alzheimer's disease in APOE e4+ carriers; CRC trans rs1814175 0.817 rs1996982 chr11:49972619 G/T cg03929089 chr4:120376271 NA -0.98 -19.36 -0.73 2.81e-56 Height; CRC cis rs10504229 1.000 rs73609762 chr8:58192695 A/G cg02725872 chr8:58115012 NA -0.38 -6.43 -0.33 4.44e-10 Developmental language disorder (linguistic errors); CRC cis rs12541635 0.966 rs2059943 chr8:107071607 G/T cg10147462 chr8:107024639 NA 0.43 7.14 0.37 5.97e-12 Age of smoking initiation; CRC cis rs1451375 0.755 rs6969081 chr7:50624505 A/T cg18232548 chr7:50535776 DDC 0.48 7.38 0.38 1.32e-12 Malaria; CRC cis rs12545109 0.959 rs12547974 chr8:57314785 G/T cg09654669 chr8:57350985 NA -0.45 -7.1 -0.36 7.65e-12 Obesity-related traits; CRC cis rs4820294 1.000 rs732856 chr22:38060691 C/G cg21798802 chr22:38057573 PDXP -0.48 -7.76 -0.39 1.1e-13 Fat distribution (HIV); CRC trans rs79976124 0.837 rs74327235 chr6:66648353 T/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.76 9.55 0.47 3.03e-19 Type 2 diabetes; CRC cis rs2836974 0.533 rs4817999 chr21:40554355 C/A cg22974920 chr21:40686053 BRWD1 -0.45 -6.34 -0.33 7.6e-10 Cognitive function; CRC cis rs6951245 1.000 rs77305932 chr7:1100861 T/A cg04025307 chr7:1156635 C7orf50 0.64 6.81 0.35 4.53e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC trans rs10802346 0.524 rs10802356 chr1:246385857 T/C cg22732515 chr19:44031385 ETHE1 0.7 10.59 0.5 9.61e-23 Fractional exhaled nitric oxide (childhood); CRC cis rs9560113 1.000 rs9555807 chr13:112179965 C/T cg10483660 chr13:112241077 NA 0.37 5.96 0.31 6.48e-9 Menarche (age at onset); CRC cis rs514406 0.505 rs425520 chr1:53179805 C/G cg27535305 chr1:53392650 SCP2 -0.34 -5.88 -0.31 9.81e-9 Monocyte count; CRC cis rs11696845 0.712 rs6130685 chr20:43366730 T/G cg25301532 chr20:43378953 KCNK15 0.37 6.2 0.32 1.69e-9 Obesity-related traits; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg07145255 chr5:59995354 DEPDC1B 0.5 7.18 0.37 4.6e-12 Response to antipsychotic treatment; CRC cis rs2860975 0.967 rs7902572 chr10:96772717 C/A cg09036531 chr10:96991505 NA -0.42 -5.71 -0.3 2.48e-8 Immune response to smallpox vaccine (IL-6); CRC cis rs737008 0.922 rs11074957 chr16:11378151 G/A cg00044050 chr16:11439710 C16orf75 -0.45 -6.1 -0.32 3.03e-9 Obesity-related traits; CRC cis rs1267303 0.642 rs3737740 chr1:47000596 G/A cg08533674 chr1:46993347 NA -0.82 -10.55 -0.5 1.33e-22 Monobrow; CRC cis rs1008375 1.000 rs28501187 chr4:17643620 G/A cg16339924 chr4:17578868 LAP3 0.59 7.93 0.4 3.47e-14 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs17818399 0.574 rs6544907 chr2:46868319 T/C cg26688816 chr2:46740690 ATP6V1E2 -0.41 -5.98 -0.31 5.77e-9 Height; CRC cis rs11997175 0.624 rs7001604 chr8:33680979 T/C cg04338863 chr8:33670619 NA 0.44 6.96 0.36 1.8e-11 Body mass index; CRC cis rs4713118 0.513 rs149944 chr6:28002818 C/T cg15786705 chr6:28176104 NA 0.59 8.76 0.43 1.05e-16 Parkinson's disease; CRC cis rs4665809 0.590 rs35746418 chr2:26455002 C/G cg22920501 chr2:26401640 FAM59B 0.83 11.96 0.55 1.28e-27 Gut microbiome composition (summer); CRC cis rs910873 0.505 rs67260051 chr20:33448417 C/T cg08999081 chr20:33150536 PIGU -0.46 -5.68 -0.3 2.91e-8 Melanoma; CRC cis rs13256369 1.000 rs7820159 chr8:8576215 T/C cg18904891 chr8:8559673 CLDN23 0.52 6.84 0.35 3.98e-11 Obesity-related traits; CRC cis rs11958404 0.932 rs72818127 chr5:157452227 C/T cg05962755 chr5:157440814 NA 1.0 12.83 0.58 7.84e-31 IgG glycosylation; CRC cis rs9311474 0.629 rs7636227 chr3:52566682 G/A cg18099408 chr3:52552593 STAB1 -0.63 -12.52 -0.57 1.16e-29 Electroencephalogram traits; CRC trans rs7618501 0.519 rs3774749 chr3:50207227 C/T cg21659725 chr3:3221576 CRBN -0.5 -7.77 -0.39 1.03e-13 Intelligence (multi-trait analysis); CRC cis rs2580764 0.566 rs2920878 chr2:55296415 C/T cg09592903 chr2:55203963 RTN4 0.71 11.4 0.53 1.35e-25 Mean platelet volume; CRC cis rs9910055 0.529 rs425038 chr17:42182028 T/C cg13607699 chr17:42295918 UBTF -0.49 -6.41 -0.33 5.11e-10 Total body bone mineral density; CRC cis rs3806843 0.676 rs778594 chr5:140027304 T/C cg19875535 chr5:140030758 IK -0.68 -11.49 -0.54 6.33e-26 Depressive symptoms (multi-trait analysis); CRC cis rs4713118 0.869 rs9283882 chr6:27715258 A/C cg08798685 chr6:27730294 NA -0.42 -6.22 -0.32 1.51e-9 Parkinson's disease; CRC cis rs459193 0.917 rs40270 chr5:55804552 A/C cg18302225 chr5:55776401 NA 0.57 7.99 0.4 2.23e-14 Coronary artery disease;Type 2 diabetes;Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);Waist-to-hip ratio adjusted for BMI in non-smokers;Waist-to-hip ratio adjusted for BMI (smoking interaction);Waist-to-hip ratio adjusted for body mass index;Waist-hip ratio;Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction); CRC cis rs10504229 0.953 rs116564484 chr8:58172818 T/C cg24829409 chr8:58192753 C8orf71 -0.67 -11.37 -0.53 1.7e-25 Developmental language disorder (linguistic errors); CRC cis rs9987353 0.589 rs1053036 chr8:9060077 A/G cg06636001 chr8:8085503 FLJ10661 -0.52 -8.15 -0.41 7.84e-15 Recombination measurement; CRC cis rs4132509 1.000 rs3766673 chr1:243720473 T/C cg21452805 chr1:244014465 NA 0.45 6.23 0.32 1.44e-9 RR interval (heart rate); CRC cis rs6748734 0.625 rs4675792 chr2:241819526 A/G cg16358738 chr2:241808595 AGXT 0.41 7.35 0.38 1.6e-12 Urinary metabolites; CRC cis rs7617773 0.780 rs13066758 chr3:48343877 G/A cg11946769 chr3:48343235 NME6 0.72 9.63 0.47 1.74e-19 Coronary artery disease; CRC cis rs9814567 1.000 rs7374158 chr3:134270156 C/T cg06541857 chr3:134203789 ANAPC13;CEP63 -0.4 -6.12 -0.32 2.65e-9 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs561341 0.941 rs8066156 chr17:30361629 A/G cg19193384 chr17:30244184 NA -0.49 -6.43 -0.33 4.49e-10 Hip circumference adjusted for BMI; CRC cis rs11971779 0.585 rs3922848 chr7:139046210 T/C cg07862535 chr7:139043722 LUC7L2 0.59 7.58 0.39 3.58e-13 Diisocyanate-induced asthma; CRC cis rs6860806 0.507 rs582490 chr5:131710095 G/A cg07395648 chr5:131743802 NA 0.43 6.0 0.31 5.26e-9 Breast cancer; CRC cis rs7833790 1.000 rs7834808 chr8:82704996 A/G cg17211192 chr8:82754475 SNX16 -0.53 -6.35 -0.33 7.35e-10 Diastolic blood pressure; CRC cis rs936229 0.861 rs7180484 chr15:75115416 G/T cg14664628 chr15:75095509 CSK 1.05 20.08 0.74 4.12e-59 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); CRC cis rs2153535 0.580 rs915351 chr6:8442793 C/T cg07606381 chr6:8435919 SLC35B3 0.68 10.86 0.51 1.08e-23 Motion sickness; CRC cis rs6860806 0.507 rs635620 chr5:131720263 A/G cg18758796 chr5:131593413 PDLIM4 -0.41 -6.59 -0.34 1.8e-10 Breast cancer; CRC cis rs9914988 0.943 rs4795459 chr17:27113726 G/C cg12682573 chr17:27188876 MIR451;MIR144 0.58 7.99 0.4 2.37e-14 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs6835098 0.924 rs13138282 chr4:174120906 C/T cg08422745 chr4:174089978 GALNT7 0.94 14.07 0.61 1.61e-35 Dementia and core Alzheimer's disease neuropathologic changes; CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg06235973 chr19:14183619 LOC113230 -0.47 -6.2 -0.32 1.7e-9 Diisocyanate-induced asthma; CRC cis rs4722166 0.532 rs6461662 chr7:22757089 C/T cg05472934 chr7:22766657 IL6 0.68 10.86 0.51 1.12e-23 Lung cancer; CRC cis rs6558174 0.965 rs2404655 chr8:22490209 T/C cg03733263 chr8:22462867 KIAA1967 0.51 6.85 0.35 3.54e-11 Breast cancer; CRC cis rs9467711 0.591 rs7748167 chr6:25904652 A/C cg16898833 chr6:26189333 HIST1H4D 0.62 5.8 0.3 1.59e-8 Autism spectrum disorder or schizophrenia; CRC cis rs921968 0.565 rs7594046 chr2:219624170 A/G cg02176678 chr2:219576539 TTLL4 0.44 6.89 0.36 2.79e-11 Mean corpuscular hemoglobin concentration; CRC cis rs4555082 0.874 rs2142190 chr14:105719306 G/A cg10792982 chr14:105748885 BRF1 0.35 5.66 0.3 3.37e-8 Mean platelet volume;Platelet distribution width; CRC cis rs7923609 0.936 rs10740125 chr10:65209609 T/C cg08743896 chr10:65200160 JMJD1C -0.42 -6.12 -0.32 2.65e-9 Educational attainment;Liver enzyme levels (alkaline phosphatase); CRC cis rs13118159 0.801 rs1128427 chr4:1330759 T/C cg20092199 chr4:1342459 KIAA1530 0.45 7.97 0.4 2.6e-14 Longevity; CRC cis rs4363385 0.510 rs11590835 chr1:153047166 T/C cg25856811 chr1:152973957 SPRR3 -0.21 -5.62 -0.3 4.03e-8 Inflammatory skin disease; CRC cis rs933688 1.000 rs2052553 chr5:90729906 C/T cg02339078 chr5:90679543 LOC100129716;ARRDC3 0.95 14.84 0.63 1.66e-38 Smoking behavior; CRC cis rs10504229 0.595 rs76447299 chr8:58117395 A/G cg22535103 chr8:58192502 C8orf71 -0.7 -9.34 -0.46 1.47e-18 Developmental language disorder (linguistic errors); CRC cis rs6445967 1.000 rs2292673 chr3:58301901 G/A cg23715586 chr3:58305044 RPP14 0.35 5.82 0.31 1.39e-8 Platelet count; CRC cis rs6540559 0.673 rs4556361 chr1:210019654 C/G cg22029157 chr1:209979665 IRF6 -0.65 -7.66 -0.39 2.12e-13 Cleft lip with or without cleft palate; CRC cis rs4363385 0.818 rs377768 chr1:153016594 T/C cg25856811 chr1:152973957 SPRR3 -0.27 -7.35 -0.38 1.6e-12 Inflammatory skin disease; CRC cis rs1005277 0.579 rs1780136 chr10:38501453 A/G cg25427524 chr10:38739819 LOC399744 -0.79 -14.49 -0.62 3.9e-37 Extrinsic epigenetic age acceleration; CRC cis rs7493 1.000 rs2299263 chr7:95040411 A/G cg19678392 chr7:94953810 PON1 0.56 7.11 0.37 7.11e-12 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs7647973 0.961 rs11130186 chr3:49275828 A/G cg07636037 chr3:49044803 WDR6 0.62 7.6 0.39 3.2e-13 Menarche (age at onset); CRC cis rs9648716 0.608 rs1267610 chr7:140525883 C/T cg17554604 chr7:140774522 NA 0.44 5.9 0.31 8.81e-9 Type 2 diabetes; CRC trans rs561341 0.882 rs28649357 chr17:30367190 A/G cg20587970 chr11:113659929 NA -1.11 -15.69 -0.65 8.5e-42 Hip circumference adjusted for BMI; CRC cis rs534126 0.778 rs6464540 chr7:142954903 G/A cg04039957 chr7:143013207 CLCN1 0.34 5.68 0.3 2.96e-8 Cancer; CRC cis rs4731207 0.596 rs7802210 chr7:124632460 A/G cg23710748 chr7:124431027 NA -0.39 -6.27 -0.33 1.15e-9 Cutaneous malignant melanoma; CRC cis rs9660992 0.573 rs1172161 chr1:205206495 C/T cg00857998 chr1:205179979 DSTYK 0.42 5.61 0.3 4.25e-8 Mean corpuscular volume;Mean platelet volume; CRC cis rs9435341 0.896 rs1730850 chr1:107597988 C/T cg14828511 chr1:107599125 PRMT6 -0.57 -8.0 -0.4 2.11e-14 Facial morphology (factor 21, depth of nasal alae); CRC cis rs7487075 0.897 rs10880960 chr12:46761829 T/G cg22049899 chr12:47219821 SLC38A4 0.33 6.02 0.32 4.54e-9 Itch intensity from mosquito bite; CRC trans rs61931739 0.500 rs11053208 chr12:34460029 A/G cg13010199 chr12:38710504 ALG10B 0.44 6.15 0.32 2.26e-9 Morning vs. evening chronotype; CRC cis rs9611565 0.512 rs139573 chr22:42214785 G/A cg03806693 chr22:41940476 POLR3H -1.09 -13.07 -0.58 9.85e-32 Vitiligo; CRC cis rs7692995 1.000 rs16896182 chr4:17973899 C/G cg08925142 chr4:18023851 LCORL -0.5 -5.65 -0.3 3.39e-8 Height; CRC cis rs1950626 0.623 rs35947256 chr14:101460366 G/T cg02351406 chr14:101447389 SNORD114-20;SNORD114-21 0.73 11.3 0.53 3.17e-25 Pelvic organ prolapse (moderate/severe); CRC cis rs977987 0.843 rs17696749 chr16:75403062 C/G cg03315344 chr16:75512273 CHST6 0.52 8.82 0.44 6.79e-17 Dupuytren's disease; CRC cis rs1348850 0.958 rs11684320 chr2:178456346 T/C cg02961200 chr2:178257176 LOC100130691;AGPS 0.47 6.8 0.35 5.08e-11 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs11864453 0.713 rs2241412 chr16:72144284 A/G cg23815491 chr16:72088622 HP 0.51 7.93 0.4 3.44e-14 Fibrinogen levels; CRC cis rs12760731 0.720 rs12691481 chr1:178392653 T/C cg00404053 chr1:178313656 RASAL2 0.85 10.04 0.48 7.48e-21 Obesity-related traits; CRC trans rs492478 0.892 rs78326948 chr5:3926201 A/G cg09199442 chr11:28132951 METT5D1 -0.7 -6.18 -0.32 1.95e-9 Cognitive performance; CRC cis rs2415984 0.622 rs7156466 chr14:46933384 A/G cg14871534 chr14:47121158 RPL10L -0.42 -5.97 -0.31 6.01e-9 Number of children ever born; CRC cis rs1144713 0.531 rs1716941 chr12:32255094 A/G cg01321189 chr12:32259338 BICD1 0.47 6.48 0.34 3.33e-10 Obesity-related traits; CRC cis rs826838 0.804 rs6580755 chr12:39159190 C/T cg26384229 chr12:38710491 ALG10B 0.71 9.7 0.47 9.96e-20 Heart rate; CRC cis rs4474465 0.850 rs10899549 chr11:78255389 T/C cg27205649 chr11:78285834 NARS2 0.49 6.26 0.33 1.22e-9 Alzheimer's disease (survival time); CRC cis rs4478858 0.775 rs6701861 chr1:31708125 A/C cg00250761 chr1:31883323 NA -0.39 -7.66 -0.39 2.09e-13 Alcohol dependence; CRC cis rs12220238 1.000 rs7897778 chr10:75916105 T/G cg19889307 chr10:75911429 ADK;AP3M1 0.62 6.1 0.32 2.94e-9 Soluble interleukin-2 receptor subunit alpha; CRC cis rs7584330 0.554 rs74001386 chr2:238425333 T/A cg14458575 chr2:238380390 NA 0.45 6.46 0.34 3.83e-10 Prostate cancer; CRC cis rs6908034 0.607 rs74573060 chr6:19806032 T/A cg02682789 chr6:19804855 NA 0.79 6.75 0.35 6.62e-11 Endometriosis;Deep ovarian and/or rectovaginal disease with dense adhesions; CRC trans rs66573146 1.000 rs6852613 chr4:7035637 G/A cg07817883 chr1:32538562 TMEM39B 1.23 10.66 0.51 5.52e-23 Granulocyte percentage of myeloid white cells; CRC cis rs738322 0.967 rs133021 chr22:38573338 T/C cg17652424 chr22:38574118 PLA2G6 -0.22 -6.5 -0.34 2.92e-10 Cutaneous nevi; CRC cis rs4713118 0.869 rs9283882 chr6:27715258 A/C cg26587870 chr6:27730563 NA -0.43 -6.69 -0.35 9.61e-11 Parkinson's disease; CRC cis rs40363 0.723 rs2379831 chr16:3538927 T/C cg22508957 chr16:3507546 NAT15 -0.79 -7.97 -0.4 2.64e-14 Tuberculosis; CRC cis rs17001868 0.568 rs74424549 chr22:40736938 A/C cg07138101 chr22:40742427 ADSL 0.59 7.84 0.4 6.24e-14 Mammographic density (dense area); CRC cis rs28386778 0.897 rs2854213 chr17:61945631 T/C cg22520471 chr17:61851767 DDX42;CCDC47 0.73 11.34 0.53 2.18e-25 Prudent dietary pattern; CRC cis rs11122272 0.735 rs2739507 chr1:231527329 T/C cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.52 -7.8 -0.4 8.04e-14 Hemoglobin concentration; CRC cis rs9611565 0.694 rs9607816 chr22:41950897 G/A cg03806693 chr22:41940476 POLR3H -1.16 -16.17 -0.67 1.12e-43 Vitiligo; CRC cis rs6952808 0.692 rs11773316 chr7:2027354 C/T cg00106254 chr7:1943704 MAD1L1 -0.53 -7.68 -0.39 1.86e-13 Bipolar disorder and schizophrenia; CRC cis rs8078723 1.000 rs4794823 chr17:38166265 A/T cg17344932 chr17:38183730 MED24;SNORD124 -0.45 -6.98 -0.36 1.62e-11 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); CRC cis rs7662987 0.517 rs2602877 chr4:100039847 T/A cg12011299 chr4:100065546 ADH4 0.49 9.25 0.45 3.02e-18 Smoking initiation; CRC cis rs7811142 0.666 rs28401739 chr7:99905684 A/G cg00814883 chr7:100076585 TSC22D4 -0.64 -7.94 -0.4 3.25e-14 Platelet count; CRC cis rs10927875 0.518 rs945416 chr1:16344402 G/A cg10494257 chr1:16342123 HSPB7 0.46 6.38 0.33 6.11e-10 Dilated cardiomyopathy; CRC cis rs9903692 0.648 rs35361214 chr17:46165091 G/A cg21215337 chr17:46176117 CBX1 0.42 7.78 0.39 9.74e-14 Pulse pressure; CRC cis rs7208859 0.623 rs8080882 chr17:29081146 G/A cg01831904 chr17:28903510 LRRC37B2 -0.62 -6.41 -0.33 5.05e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs9292777 0.897 rs10473191 chr5:40412944 T/A cg09067459 chr5:40385259 NA 0.51 8.86 0.44 4.94e-17 Crohn's disease;Multiple sclerosis; CRC cis rs1832871 0.655 rs6920121 chr6:158678504 C/T cg07165851 chr6:158734300 TULP4 -0.61 -7.85 -0.4 5.87e-14 Height; CRC cis rs9348721 0.673 rs9358934 chr6:26363755 G/C cg14345882 chr6:26364793 BTN3A2 0.65 5.73 0.3 2.32e-8 Intelligence (multi-trait analysis); CRC cis rs1045714 0.895 rs1107690 chr7:2640595 G/T cg24848437 chr7:2645542 IQCE 0.58 6.13 0.32 2.45e-9 Urate levels in lean individuals; CRC cis rs7980687 0.628 rs1609520 chr12:123735937 A/G cg00376283 chr12:123451042 ABCB9 -0.52 -7.05 -0.36 1.03e-11 Height;Educational attainment;Head circumference (infant); CRC cis rs12142240 0.698 rs4372193 chr1:46853233 G/T cg14993813 chr1:46806288 NSUN4 -0.48 -6.03 -0.32 4.47e-9 Menopause (age at onset); CRC cis rs9443645 0.901 rs9443632 chr6:79664440 T/C cg11833968 chr6:79620685 NA -0.36 -6.16 -0.32 2.1e-9 Intelligence (multi-trait analysis); CRC cis rs2842992 0.830 rs2842974 chr6:160159034 C/T cg16489826 chr6:160211363 TCP1;MRPL18 0.46 5.75 0.3 2.01e-8 Age-related macular degeneration (geographic atrophy); CRC cis rs6121246 0.909 rs6060644 chr20:30265652 G/A cg13852791 chr20:30311386 BCL2L1 0.69 11.0 0.52 3.61e-24 Mean corpuscular hemoglobin; CRC cis rs2070488 0.861 rs2067082 chr3:38438182 C/G cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.84 15.15 0.64 1.08e-39 Electrocardiographic conduction measures; CRC cis rs10484885 0.887 rs17707738 chr6:90602735 G/A cg13799429 chr6:90582589 CASP8AP2 -0.72 -8.41 -0.42 1.25e-15 QRS interval (sulfonylurea treatment interaction); CRC trans rs12517041 1.000 rs4701363 chr5:23301008 T/C ch.8.1293020R chr8:59333349 UBXN2B -0.54 -5.96 -0.31 6.46e-9 Calcium levels; CRC cis rs7586879 1.000 rs7586879 chr2:25116977 C/T cg04586622 chr2:25135609 ADCY3 -0.43 -7.17 -0.37 5.06e-12 Body mass index; CRC cis rs8060686 0.858 rs10468274 chr16:67922342 C/T cg19582491 chr16:67682965 RLTPR -0.4 -5.62 -0.3 4e-8 HDL cholesterol;Metabolic syndrome; CRC cis rs4713118 0.516 rs7739216 chr6:28079946 G/T cg12172441 chr6:28176163 NA 0.62 7.28 0.37 2.53e-12 Parkinson's disease; CRC cis rs736801 0.569 rs11748193 chr5:131725329 A/T cg07395648 chr5:131743802 NA -0.41 -6.11 -0.32 2.84e-9 Breast cancer;Mosquito bite size; CRC cis rs7781266 0.741 rs1149555 chr7:133062665 G/A cg03336402 chr7:133662267 EXOC4 -0.47 -5.7 -0.3 2.7e-8 Educational attainment (college completion); CRC cis rs629535 0.911 rs627382 chr8:70014081 C/T cg26132723 chr8:70041827 NA -0.36 -5.99 -0.31 5.59e-9 Dupuytren's disease; CRC trans rs7615952 0.512 rs4679430 chr3:125357893 T/C cg21747405 chr11:67723411 NA -0.58 -9.13 -0.45 6.88e-18 Blood pressure (smoking interaction); CRC cis rs9322193 0.607 rs4869755 chr6:150207483 G/A cg13206674 chr6:150067644 NUP43 0.47 5.75 0.3 2.09e-8 Lung cancer; CRC cis rs1670533 1.000 rs6812586 chr4:1069851 A/G cg27284194 chr4:1044797 NA 0.48 6.07 0.32 3.51e-9 Recombination rate (females); CRC cis rs9914988 0.943 rs9913801 chr17:27132105 G/A cg12682573 chr17:27188876 MIR451;MIR144 0.58 7.99 0.4 2.37e-14 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs6912958 0.781 rs4707379 chr6:88310623 A/G cg12350822 chr6:88032061 C6orf162;GJB7 -0.33 -6.27 -0.33 1.1e-9 Monocyte percentage of white cells; CRC cis rs3857067 1.000 rs1588385 chr4:95017161 A/G cg11021082 chr4:95130006 SMARCAD1 -0.4 -6.05 -0.32 3.9e-9 QT interval; CRC cis rs875971 0.862 rs2460432 chr7:65554385 C/T cg18252515 chr7:66147081 NA 0.41 6.04 0.32 4.07e-9 Aortic root size; CRC cis rs9291683 0.509 rs6849717 chr4:9958719 T/C cg00071950 chr4:10020882 SLC2A9 -0.65 -12.09 -0.55 4.31e-28 Bone mineral density; CRC cis rs4820539 1.000 rs6003518 chr22:23471533 C/T cg14186256 chr22:23484241 RTDR1 0.91 18.08 0.71 3.1e-51 Bone mineral density; CRC cis rs11098499 0.779 rs72918579 chr4:120333222 G/C cg09307838 chr4:120376055 NA 0.71 10.69 0.51 4.29e-23 Corneal astigmatism; CRC cis rs10883723 0.810 rs7912901 chr10:104277440 T/C cg11453585 chr10:104263688 ACTR1A;SUFU 0.91 17.47 0.69 8.43e-49 Allergic disease (asthma, hay fever or eczema); CRC cis rs1862618 0.511 rs2591952 chr5:56120769 T/A cg24531977 chr5:56204891 C5orf35 -0.79 -10.73 -0.51 3.02e-23 Initial pursuit acceleration; CRC cis rs7945705 0.967 rs2568090 chr11:8849495 T/C cg14711859 chr11:8959438 ASCL3 -0.45 -7.25 -0.37 2.97e-12 Hemoglobin concentration; CRC cis rs758324 0.898 rs11958749 chr5:131166014 T/C cg06307176 chr5:131281290 NA 0.43 6.56 0.34 2.06e-10 Alzheimer's disease in APOE e4- carriers; CRC cis rs9916302 0.706 rs9944459 chr17:37484185 T/C cg00129232 chr17:37814104 STARD3 0.56 6.98 0.36 1.67e-11 Glomerular filtration rate (creatinine); CRC cis rs25422 0.938 rs62422193 chr6:118912285 G/A cg24463073 chr6:118973353 C6orf204 0.54 7.13 0.37 6.33e-12 Renal cell carcinoma; CRC trans rs1005277 0.579 rs2472173 chr10:38374638 G/A cg17830980 chr10:43048298 ZNF37B -0.58 -9.66 -0.47 1.39e-19 Extrinsic epigenetic age acceleration; CRC cis rs4689388 0.581 rs1801212 chr4:6302519 C/T cg25554036 chr4:6271136 WFS1 0.56 7.64 0.39 2.46e-13 Type 2 diabetes and other traits;Type 2 diabetes; CRC cis rs7680126 0.633 rs887732 chr4:10183117 G/C cg00071950 chr4:10020882 SLC2A9 -0.46 -5.95 -0.31 6.92e-9 Urate levels in lean individuals;Urate levels in overweight individuals;Urate levels in obese individuals; CRC cis rs7264396 1.000 rs224430 chr20:34153341 C/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.47 -7.78 -0.39 9.16e-14 Total cholesterol levels; CRC cis rs35110281 0.667 rs7282405 chr21:45123611 C/G cg04455712 chr21:45112962 RRP1B 0.42 8.03 0.4 1.74e-14 Mean corpuscular volume; CRC cis rs2333194 0.875 rs7140876 chr14:73792938 A/G cg19682024 chr14:74008259 HEATR4;ACOT1 -0.42 -6.28 -0.33 1.07e-9 Bipolar disorder with mood-incongruent psychosis; CRC cis rs12893668 0.572 rs4900591 chr14:104154878 G/A cg24130564 chr14:104152367 KLC1 -0.43 -5.78 -0.3 1.77e-8 Reticulocyte count; CRC trans rs9914544 0.545 rs4924944 chr17:18810002 C/T cg21372672 chr17:16614065 CCDC144A -0.43 -6.9 -0.36 2.76e-11 Educational attainment (years of education); CRC cis rs9787249 0.957 rs41267029 chr1:40214367 A/G cg01941586 chr1:40203715 PPIE -0.45 -6.18 -0.32 1.91e-9 Blood protein levels; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg03640568 chr22:38902623 DDX17 0.44 6.26 0.33 1.18e-9 Intelligence (multi-trait analysis); CRC cis rs561341 1.000 rs550923 chr17:30327013 G/C cg19193384 chr17:30244184 NA -0.65 -7.57 -0.39 3.82e-13 Hip circumference adjusted for BMI; CRC cis rs910316 0.967 rs119076 chr14:75572419 G/T cg08847533 chr14:75593920 NEK9 -0.88 -16.64 -0.68 1.55e-45 Height; CRC cis rs780096 0.506 rs1647265 chr2:27692261 A/G cg24768116 chr2:27665128 KRTCAP3 -0.36 -8.12 -0.41 9.76e-15 Total body bone mineral density; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg21309049 chr7:43623222 STK17A 0.41 6.02 0.31 4.6e-9 Intelligence (multi-trait analysis); CRC cis rs1008375 0.932 rs11938710 chr4:17670664 G/C cg16339924 chr4:17578868 LAP3 -0.51 -6.35 -0.33 7.17e-10 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs8177253 0.665 rs9831392 chr3:133451473 A/T cg11941060 chr3:133502564 NA -0.47 -7.65 -0.39 2.28e-13 Iron status biomarkers; CRC cis rs12701220 0.655 rs10241018 chr7:1144774 G/C cg02733842 chr7:1102375 C7orf50 -0.66 -8.04 -0.41 1.66e-14 Bronchopulmonary dysplasia; CRC cis rs6860806 0.507 rs273901 chr5:131694360 G/T cg04518342 chr5:131593106 PDLIM4 0.43 7.04 0.36 1.14e-11 Breast cancer; CRC cis rs2795502 1.000 rs2744092 chr10:43339343 T/C cg20628663 chr10:43360327 NA -0.69 -10.81 -0.51 1.67e-23 Blood protein levels; CRC cis rs9309473 0.607 rs11686504 chr2:73579812 T/C cg20560298 chr2:73613845 ALMS1 -0.47 -6.45 -0.34 4.01e-10 Metabolite levels; CRC cis rs4713118 0.911 rs9461406 chr6:27719764 C/T cg12172441 chr6:28176163 NA -0.54 -6.59 -0.34 1.74e-10 Parkinson's disease; CRC cis rs73206853 0.534 rs73205059 chr12:110509947 G/A cg12870014 chr12:110450643 ANKRD13A 0.86 8.88 0.44 4.53e-17 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC trans rs61931739 0.517 rs34760282 chr12:34153711 G/T cg26384229 chr12:38710491 ALG10B 0.57 7.26 0.37 2.88e-12 Morning vs. evening chronotype; CRC cis rs7584330 0.697 rs9287620 chr2:238368730 C/T cg14458575 chr2:238380390 NA 0.71 12.44 0.57 2.31e-29 Prostate cancer; CRC cis rs6952808 0.582 rs11763870 chr7:2027448 T/C cg22963979 chr7:1858916 MAD1L1 0.42 6.44 0.33 4.11e-10 Bipolar disorder and schizophrenia; CRC cis rs10540 1.000 rs61876333 chr11:487136 G/A cg03352830 chr11:487213 PTDSS2 0.65 6.84 0.35 3.92e-11 Body mass index; CRC cis rs1707322 1.000 rs11211190 chr1:46266255 C/T cg06784218 chr1:46089804 CCDC17 0.5 8.68 0.43 1.87e-16 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC trans rs11992186 0.505 rs7845203 chr8:8145440 A/G cg16141378 chr3:129829833 LOC729375 -0.4 -6.02 -0.31 4.65e-9 Neuroticism; CRC cis rs28386778 0.897 rs2854221 chr17:61941445 G/T cg22520471 chr17:61851767 DDX42;CCDC47 0.73 11.49 0.54 6.52e-26 Prudent dietary pattern; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg13435101 chr6:74171350 MTO1 -0.44 -6.78 -0.35 5.73e-11 Liver disease severity in Alagille syndrome; CRC cis rs875971 0.964 rs778708 chr7:65856319 T/C cg12463550 chr7:65579703 CRCP 0.48 6.96 0.36 1.89e-11 Aortic root size; CRC cis rs12142240 0.698 rs1475390 chr1:46816340 A/G cg14993813 chr1:46806288 NSUN4 -0.5 -6.4 -0.33 5.38e-10 Menopause (age at onset); CRC cis rs9814567 1.000 rs7637227 chr3:134244155 G/A cg06109529 chr3:134205091 CEP63;ANAPC13 -0.82 -12.16 -0.56 2.28e-28 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs7618501 0.516 rs2856236 chr3:50161717 A/C cg24308560 chr3:49941425 MST1R 0.48 7.73 0.39 1.29e-13 Intelligence (multi-trait analysis); CRC cis rs1572438 0.965 rs3799324 chr6:859376 G/A cg21062780 chr6:887772 NA -0.39 -5.98 -0.31 5.66e-9 Aging; CRC cis rs6502050 0.635 rs9889327 chr17:80087839 G/A cg22110888 chr17:80059540 CCDC57 0.4 6.34 0.33 7.4e-10 Life satisfaction; CRC cis rs713587 0.713 rs4665276 chr2:25213333 C/T cg22495460 chr2:25135724 ADCY3 0.67 11.11 0.52 1.51e-24 Body mass index in non-asthmatics; CRC cis rs2204008 0.774 rs11616004 chr12:38278822 G/A cg13010199 chr12:38710504 ALG10B 0.45 5.75 0.3 2.07e-8 Bladder cancer; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg16515820 chr3:114866447 ZBTB20 0.47 6.14 0.32 2.39e-9 Thyroid stimulating hormone; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg07286436 chr15:43425883 TMEM62 0.42 6.22 0.32 1.53e-9 Intelligence (multi-trait analysis); CRC cis rs1448094 0.617 rs1393612 chr12:86474576 T/C cg02569458 chr12:86230093 RASSF9 -0.42 -7.12 -0.37 6.98e-12 Major depressive disorder; CRC cis rs7618501 0.633 rs13060128 chr3:50025028 A/G cg05623727 chr3:50126028 RBM5 0.45 7.6 0.39 3.11e-13 Intelligence (multi-trait analysis); CRC cis rs11098499 0.955 rs11931312 chr4:120159023 T/C cg24375607 chr4:120327624 NA 0.43 6.68 0.35 1.04e-10 Corneal astigmatism; CRC cis rs62408225 1.000 rs62408236 chr6:90980148 C/T cg06866423 chr6:90926672 BACH2 0.48 7.9 0.4 4.25e-14 Eosinophil counts;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC cis rs28386778 0.897 rs1877318 chr17:61819960 G/A cg06873352 chr17:61820015 STRADA 0.78 14.61 0.63 1.36e-37 Prudent dietary pattern; CRC trans rs1728785 0.901 rs1103286 chr16:68578625 C/T cg04657470 chr2:198365150 HSPE1;HSPD1 0.58 7.07 0.36 9.08e-12 Ulcerative colitis; CRC cis rs897080 0.515 rs1085495 chr2:44608982 A/G cg04920474 chr2:44395004 PPM1B 0.44 6.13 0.32 2.48e-9 Height; CRC cis rs40363 0.645 rs250629 chr16:3525431 C/A cg05754148 chr16:3507555 NAT15 0.48 6.71 0.35 8.71e-11 Tuberculosis; CRC cis rs6120849 0.754 rs3746446 chr20:33574765 T/C cg08999081 chr20:33150536 PIGU 0.45 5.77 0.3 1.86e-8 Protein C levels; CRC cis rs6758955 0.925 rs76748106 chr2:10480890 C/T cg15773312 chr2:10472214 HPCAL1 -0.74 -8.88 -0.44 4.31e-17 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; CRC cis rs2075371 0.897 rs1643033 chr7:134004662 T/C cg11752832 chr7:134001865 SLC35B4 0.49 7.52 0.38 5.26e-13 Mean platelet volume; CRC trans rs7395662 0.926 rs11039893 chr11:48657754 G/A cg21153622 chr11:89784906 NA -0.47 -7.59 -0.39 3.27e-13 HDL cholesterol; CRC trans rs875971 0.660 rs2191268 chr7:66110224 C/T cg11321895 chr8:57123832 PLAG1;CHCHD7 -0.39 -6.05 -0.32 3.93e-9 Aortic root size; CRC cis rs877282 0.945 rs12767287 chr10:787310 A/G cg17470449 chr10:769945 NA 0.66 8.59 0.43 3.44e-16 Uric acid levels; CRC cis rs7727544 0.735 rs272884 chr5:131668654 G/C cg07395648 chr5:131743802 NA -0.4 -6.37 -0.33 6.4e-10 Blood metabolite levels; CRC cis rs35306767 0.903 rs35957139 chr10:884889 C/T cg20503657 chr10:835505 NA 1.26 14.89 0.63 1.11e-38 Eosinophil percentage of granulocytes; CRC cis rs8072100 0.967 rs3760370 chr17:45695832 C/T cg08085267 chr17:45401833 C17orf57 0.62 9.74 0.47 7.41e-20 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs951366 0.903 rs823116 chr1:205720483 G/A cg14893161 chr1:205819251 PM20D1 0.48 7.29 0.37 2.28e-12 Menarche (age at onset); CRC cis rs798554 0.836 rs798490 chr7:2801542 C/T cg14895029 chr7:2775587 GNA12 -0.44 -6.33 -0.33 8.24e-10 Height; CRC cis rs834811 0.563 rs834814 chr7:135887515 A/G cg01726295 chr7:135938950 NA 0.35 6.05 0.32 3.94e-9 Post-traumatic stress disorder; CRC cis rs2153535 0.580 rs7775909 chr6:8477778 A/G cg21535247 chr6:8435926 SLC35B3 0.5 7.52 0.38 5.18e-13 Motion sickness; CRC cis rs951366 0.789 rs7536483 chr1:205718858 A/T cg11965913 chr1:205819406 PM20D1 0.81 12.99 0.58 1.94e-31 Menarche (age at onset); CRC trans rs1814175 0.904 rs1846289 chr11:49620253 G/A cg11707556 chr5:10655725 ANKRD33B -0.43 -8.08 -0.41 1.29e-14 Height; CRC cis rs10504229 0.683 rs79262965 chr8:58129826 G/T cg02725872 chr8:58115012 NA -0.58 -8.39 -0.42 1.5e-15 Developmental language disorder (linguistic errors); CRC cis rs7487075 0.780 rs12320197 chr12:46738883 A/G cg17501823 chr12:47219793 SLC38A4 0.31 5.62 0.3 4.14e-8 Itch intensity from mosquito bite; CRC cis rs12701220 0.817 rs1058727 chr7:1087095 A/G cg02733842 chr7:1102375 C7orf50 -0.59 -7.7 -0.39 1.6e-13 Bronchopulmonary dysplasia; CRC cis rs6500395 1.000 rs7206647 chr16:48709220 G/C cg04672837 chr16:48644449 N4BP1 -0.45 -6.63 -0.34 1.38e-10 Response to tocilizumab in rheumatoid arthritis; CRC cis rs17270561 0.609 rs6924794 chr6:25735874 A/G cg16482183 chr6:26056742 HIST1H1C 0.83 10.58 0.5 1.07e-22 Iron status biomarkers; CRC cis rs4974559 0.501 rs1732115 chr4:1244416 C/T cg02980000 chr4:1222292 CTBP1 0.68 7.93 0.4 3.39e-14 Systolic blood pressure; CRC cis rs3858526 0.584 rs10769276 chr11:5868020 G/T cg26762873 chr11:5879799 OR52E8 -0.49 -7.46 -0.38 7.84e-13 DNA methylation (variation); CRC cis rs2635047 0.811 rs28471970 chr18:44788439 G/C cg19077165 chr18:44547161 KATNAL2 -0.38 -5.85 -0.31 1.2e-8 Educational attainment; CRC cis rs7659604 0.582 rs3217780 chr4:122737278 T/C cg19748678 chr4:122722346 EXOSC9 0.65 10.3 0.49 9.67e-22 Type 2 diabetes; CRC trans rs9747201 1.000 rs9747668 chr17:80161081 A/G cg07393940 chr7:158741817 NA 0.49 7.17 0.37 4.91e-12 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs3617 0.652 rs60332615 chr3:52867595 C/A cg15147215 chr3:52552868 STAB1 0.53 9.17 0.45 5.31e-18 Red blood cell count;Autism spectrum disorder or schizophrenia; CRC cis rs2629540 0.889 rs4962699 chr10:126477209 A/G cg08799069 chr10:126477246 METTL10 -0.64 -9.07 -0.45 1.09e-17 Cocaine dependence; CRC cis rs4824093 0.544 rs7410274 chr22:50315928 C/G cg22709217 chr22:50311962 ALG12;CRELD2 -0.88 -7.85 -0.4 5.86e-14 Amyotrophic lateral sclerosis (sporadic); CRC cis rs4713118 0.869 rs9295743 chr6:27715102 G/C cg12273811 chr6:28175739 NA 0.54 7.7 0.39 1.59e-13 Parkinson's disease; CRC cis rs9325144 0.534 rs4882350 chr12:38686979 A/G cg26384229 chr12:38710491 ALG10B 0.54 8.16 0.41 7.11e-15 Morning vs. evening chronotype; CRC cis rs28386778 0.897 rs6504187 chr17:61917099 G/A cg23090583 chr17:61904693 PSMC5;FTSJ3 1.05 20.14 0.74 2.41e-59 Prudent dietary pattern; CRC cis rs2842992 0.724 rs9347340 chr6:160188891 C/T cg16489826 chr6:160211363 TCP1;MRPL18 -0.62 -9.26 -0.45 2.75e-18 Age-related macular degeneration (geographic atrophy); CRC cis rs514406 0.825 rs9661082 chr1:53245472 A/T cg27535305 chr1:53392650 SCP2 0.39 7.07 0.36 9.43e-12 Monocyte count; CRC cis rs3743162 0.553 rs4842994 chr15:85415799 A/G cg17507749 chr15:85114479 UBE2QP1 -0.54 -7.26 -0.37 2.75e-12 Alzheimer's disease (age of onset); CRC cis rs4713118 0.869 rs10214440 chr6:27702440 A/C cg15786705 chr6:28176104 NA 0.57 7.9 0.4 4.29e-14 Parkinson's disease; CRC trans rs7618501 0.519 rs3774750 chr3:50208406 C/G cg21659725 chr3:3221576 CRBN -0.49 -7.64 -0.39 2.4e-13 Intelligence (multi-trait analysis); CRC cis rs7149337 0.805 rs2999354 chr14:51607179 C/G cg18683604 chr14:51561293 TRIM9 0.29 6.0 0.31 5.11e-9 Cancer; CRC cis rs875971 0.862 rs778720 chr7:65846275 A/C cg12463550 chr7:65579703 CRCP -0.5 -7.13 -0.37 6.57e-12 Aortic root size; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg02323633 chr5:73937762 ENC1 0.48 6.88 0.35 3.03e-11 Response to antipsychotic treatment; CRC cis rs2239547 0.657 rs13072536 chr3:52861211 A/T cg15147215 chr3:52552868 STAB1 -0.43 -6.09 -0.32 3.12e-9 Schizophrenia; CRC cis rs546131 0.890 rs485845 chr11:34830389 G/T cg11058730 chr11:34937778 PDHX;APIP -0.45 -6.39 -0.33 5.59e-10 Lung disease severity in cystic fibrosis; CRC cis rs7264396 0.635 rs7263302 chr20:34545858 T/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.61 -9.82 -0.48 4.01e-20 Total cholesterol levels; CRC cis rs9467711 0.651 rs35402046 chr6:26099472 G/A cg19084075 chr6:26124329 HIST1H2AC;HIST1H2BC 0.63 5.88 0.31 1.01e-8 Autism spectrum disorder or schizophrenia; CRC cis rs17767392 0.958 rs4902938 chr14:72014778 T/C cg13720639 chr14:72061746 SIPA1L1 0.56 7.14 0.37 6.03e-12 Mitral valve prolapse; CRC cis rs67311347 0.955 rs6599100 chr3:40447362 C/T cg24209194 chr3:40518798 ZNF619 0.42 6.44 0.33 4.23e-10 Renal cell carcinoma; CRC cis rs1448094 0.556 rs11614513 chr12:86167756 G/C cg18827107 chr12:86230957 RASSF9 -0.41 -6.23 -0.32 1.42e-9 Major depressive disorder; CRC cis rs9914988 0.945 rs9279 chr17:27187636 G/T cg16670446 chr17:27188758 MIR451;MIR144 -0.61 -10.48 -0.5 2.34e-22 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs7258465 0.897 rs1043327 chr19:18554972 A/G cg06953865 chr19:18549723 ISYNA1 -0.38 -5.76 -0.3 1.89e-8 Breast cancer; CRC cis rs853679 0.517 rs4713143 chr6:28106759 A/C cg18032046 chr6:28092343 ZSCAN16 -0.52 -6.08 -0.32 3.3e-9 Depression; CRC cis rs55794721 0.509 rs7554255 chr1:25778106 C/T cg02931644 chr1:25747376 RHCE 0.32 5.68 0.3 2.94e-8 Plateletcrit;Mean corpuscular volume; CRC cis rs11122272 0.735 rs2486746 chr1:231497324 C/T cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.51 -7.72 -0.39 1.41e-13 Hemoglobin concentration; CRC trans rs2727020 0.554 rs2866490 chr11:49425463 A/G cg03929089 chr4:120376271 NA -0.72 -9.13 -0.45 7.04e-18 Coronary artery disease; CRC trans rs17685 0.672 rs1639618 chr7:75701987 T/C cg19862616 chr7:65841803 NCRNA00174 0.99 18.51 0.71 6.2e-53 Coffee consumption;Coffee consumption (cups per day); CRC cis rs67478160 0.572 rs8015603 chr14:104293678 C/G cg01849466 chr14:104193079 ZFYVE21 -0.48 -8.24 -0.41 4.12e-15 Schizophrenia; CRC cis rs6540559 0.673 rs58637469 chr1:209971480 T/A cg25204440 chr1:209979598 IRF6 0.48 5.82 0.31 1.42e-8 Cleft lip with or without cleft palate; CRC cis rs17345786 0.953 rs78645744 chr3:101327789 T/A cg12386194 chr3:101231763 SENP7 0.55 7.04 0.36 1.13e-11 Colonoscopy-negative controls vs population controls; CRC cis rs79387448 0.745 rs17027496 chr2:103178223 T/A cg21010569 chr2:103233596 NA 0.49 5.67 0.3 3.15e-8 Gut microbiota (bacterial taxa); CRC cis rs853679 0.607 rs13190888 chr6:28285985 G/A cg12185399 chr6:27640341 NA 0.83 6.03 0.32 4.38e-9 Depression; CRC cis rs77861329 1.000 rs352147 chr3:52208285 A/G cg08692210 chr3:52188851 WDR51A 0.83 7.8 0.4 8.22e-14 Macrophage inflammatory protein 1b levels; CRC cis rs1018836 0.564 rs7821994 chr8:91700916 C/T cg16814680 chr8:91681699 NA -0.98 -21.08 -0.76 4.95e-63 Ejection fraction in Tripanosoma cruzi seropositivity; CRC cis rs10512697 0.655 rs35451111 chr5:3466737 A/G cg19473799 chr5:3511975 NA -0.83 -6.35 -0.33 7.32e-10 Immune response to smallpox vaccine (IL-6); CRC trans rs10982213 0.830 rs2274163 chr9:117188714 C/T cg16458507 chr12:113376293 OAS3 0.38 6.05 0.32 4.01e-9 Interleukin-6 levels; CRC cis rs6942756 0.737 rs61570833 chr7:128933492 C/A cg02491457 chr7:128862824 NA -0.78 -10.68 -0.51 4.86e-23 White matter hyperintensity burden; CRC cis rs12421382 0.511 rs2212430 chr11:109289538 C/T cg27471124 chr11:109292789 C11orf87 0.3 5.99 0.31 5.6e-9 Schizophrenia; CRC cis rs3820068 0.705 rs4646103 chr1:15819827 T/A cg27534772 chr1:16042836 PLEKHM2 0.39 6.64 0.34 1.26e-10 Systolic blood pressure; CRC trans rs12200782 0.649 rs12189870 chr6:26382765 T/G cg25800765 chr12:85673347 ALX1 0.26 5.96 0.31 6.54e-9 Small cell lung carcinoma; CRC cis rs3858526 0.584 rs10769270 chr11:5860563 T/C cg02574844 chr11:5959923 NA -0.49 -6.97 -0.36 1.7e-11 DNA methylation (variation); CRC cis rs4604732 0.631 rs12080860 chr1:247623053 A/G cg02104434 chr1:247694406 LOC148824;OR2C3 0.64 9.26 0.45 2.75e-18 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CRC cis rs4750440 0.614 rs4750446 chr10:14030319 T/G cg00551146 chr10:14014579 FRMD4A 0.43 6.9 0.36 2.66e-11 Adiponectin levels; CRC cis rs9902453 0.740 rs2617884 chr17:28120430 G/C cg26525008 chr17:28256777 EFCAB5;SSH2 -0.73 -12.23 -0.56 1.28e-28 Coffee consumption (cups per day); CRC cis rs853679 0.760 rs11962305 chr6:28199937 G/C cg12273811 chr6:28175739 NA 0.54 5.81 0.3 1.5e-8 Depression; CRC cis rs7914558 0.966 rs3902934 chr10:104746649 A/G cg15744005 chr10:104629667 AS3MT -0.35 -7.42 -0.38 9.92e-13 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs62458065 0.513 rs10268149 chr7:32575499 T/C cg20159608 chr7:32802032 NA -0.63 -8.09 -0.41 1.13e-14 Metabolite levels (HVA/MHPG ratio); CRC cis rs6502050 0.765 rs6502075 chr17:80121813 G/A cg19223190 chr17:80058835 NA 0.39 6.23 0.32 1.43e-9 Life satisfaction; CRC cis rs8016982 0.674 rs1957549 chr14:81706179 G/A cg01989461 chr14:81687754 GTF2A1 0.66 10.7 0.51 3.9e-23 Schizophrenia; CRC cis rs2075371 0.764 rs1643034 chr7:134006176 A/G cg11752832 chr7:134001865 SLC35B4 0.5 7.83 0.4 6.6e-14 Mean platelet volume; CRC cis rs10504229 1.000 rs66840104 chr8:58190001 C/T cg24829409 chr8:58192753 C8orf71 -0.68 -11.34 -0.53 2.27e-25 Developmental language disorder (linguistic errors); CRC cis rs9303542 0.625 rs9904760 chr17:46575031 C/T cg04904318 chr17:46607828 HOXB1 -0.49 -6.47 -0.34 3.47e-10 Ovarian cancer;Epithelial ovarian cancer; CRC cis rs854765 0.964 rs2230316 chr17:17997209 C/T cg09796270 chr17:17721594 SREBF1 -0.47 -7.37 -0.38 1.43e-12 Total body bone mineral density; CRC cis rs28386778 0.742 rs3020617 chr17:61947303 A/G cg06873352 chr17:61820015 STRADA 0.75 13.57 0.6 1.33e-33 Prudent dietary pattern; CRC cis rs2346160 0.867 rs412495 chr6:167688940 C/G cg27333441 chr6:167680455 NA 0.33 5.61 0.3 4.2e-8 Parental extreme longevity (95 years and older); CRC trans rs6703335 0.870 rs10803142 chr1:243598234 A/G cg06028048 chr5:175815674 HIGD2A;NOP16 0.46 6.61 0.34 1.59e-10 Schizophrenia;Schizophrenia, schizoaffective disorder or bipolar disorder; CRC cis rs3617 0.573 rs2336667 chr3:52916363 C/T cg11645453 chr3:52864694 ITIH4 -0.38 -7.18 -0.37 4.8e-12 Red blood cell count;Autism spectrum disorder or schizophrenia; CRC cis rs3733585 0.683 rs6449140 chr4:9936437 G/C cg11266682 chr4:10021025 SLC2A9 -0.52 -10.51 -0.5 1.82e-22 Cleft plate (environmental tobacco smoke interaction); CRC cis rs1552244 0.882 rs36006511 chr3:10054191 C/T cg16606324 chr3:10149918 C3orf24 0.64 8.2 0.41 5.35e-15 Alzheimer's disease; CRC cis rs3791556 0.741 rs3791542 chr2:240103955 A/G cg03281426 chr2:240109471 HDAC4 -0.52 -6.08 -0.32 3.34e-9 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs1448094 0.817 rs10863121 chr12:86343834 A/C cg02569458 chr12:86230093 RASSF9 -0.47 -7.94 -0.4 3.16e-14 Major depressive disorder; CRC trans rs3960554 0.674 rs112742093 chr7:75800597 T/C cg19862616 chr7:65841803 NCRNA00174 0.74 8.53 0.43 5.62e-16 Eotaxin levels; CRC cis rs898097 0.841 rs55810435 chr17:80836722 G/C cg19046167 chr17:80928561 B3GNTL1 -0.44 -6.79 -0.35 5.24e-11 Breast cancer; CRC cis rs67478160 0.643 rs6575997 chr14:104228546 C/T cg01849466 chr14:104193079 ZFYVE21 0.5 8.55 0.43 4.73e-16 Schizophrenia; CRC cis rs8180040 0.966 rs6765990 chr3:47542894 G/A cg02527881 chr3:46936655 PTH1R -0.41 -7.84 -0.4 6.48e-14 Colorectal cancer; CRC cis rs501120 0.584 rs58540467 chr10:44705170 T/C cg09554077 chr10:44749378 NA 0.66 7.65 0.39 2.25e-13 Coronary artery disease;Coronary heart disease; CRC cis rs6545883 0.965 rs778752 chr2:61776902 C/G cg15711740 chr2:61764176 XPO1 -0.5 -7.02 -0.36 1.27e-11 Tuberculosis; CRC cis rs2230307 0.536 rs11166385 chr1:100443462 A/G cg24955406 chr1:100503596 HIAT1 0.59 7.13 0.37 6.35e-12 Carotid intima media thickness; CRC cis rs1801251 0.893 rs6733151 chr2:233592341 A/C cg25237894 chr2:233734115 C2orf82 0.54 8.77 0.44 9.91e-17 Coronary artery disease; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg08755283 chr5:118324104 DTWD2 -0.47 -7.13 -0.37 6.23e-12 Myopia (pathological); CRC trans rs1455244 0.700 rs7229302 chr18:11508904 G/T cg15921099 chr2:121010219 RALB 0.39 6.17 0.32 2.01e-9 Schizophrenia; CRC cis rs9291683 0.530 rs11723970 chr4:9980462 T/C cg00071950 chr4:10020882 SLC2A9 0.64 11.86 0.55 3.03e-27 Bone mineral density; CRC cis rs3858526 0.642 rs55732658 chr11:5894602 A/C cg13902645 chr11:5959945 NA -0.56 -7.2 -0.37 4.15e-12 DNA methylation (variation); CRC cis rs1552244 0.816 rs56387520 chr3:10042782 C/T cg00166722 chr3:10149974 C3orf24 0.61 8.0 0.4 2.17e-14 Alzheimer's disease; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg20505218 chr17:80009845 GPS1;RFNG 0.48 6.14 0.32 2.36e-9 Thyroid stimulating hormone; CRC cis rs875971 1.000 rs1981798 chr7:65954903 G/T cg18876405 chr7:65276391 NA 0.52 8.59 0.43 3.65e-16 Aortic root size; CRC cis rs4713675 0.565 rs3818524 chr6:33660695 G/C cg14003231 chr6:33640908 ITPR3 0.53 8.61 0.43 2.99e-16 Plateletcrit; CRC cis rs7917772 0.636 rs1475644 chr10:104491164 G/A cg22532475 chr10:104410764 TRIM8 -0.36 -6.13 -0.32 2.52e-9 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC cis rs2976388 0.669 rs2976391 chr8:143762724 C/A cg12516270 chr8:143859308 LYNX1 0.35 6.0 0.31 5.14e-9 Urinary tract infection frequency; CRC cis rs12142240 0.698 rs41294478 chr1:46818442 G/A cg00530320 chr1:46809349 NSUN4 0.58 7.93 0.4 3.43e-14 Menopause (age at onset); CRC trans rs10411161 0.657 rs67462252 chr19:52382851 T/C cg22319618 chr22:45562946 NUP50 -0.69 -7.57 -0.39 3.68e-13 Breast cancer; CRC cis rs7772486 0.686 rs6570705 chr6:145961201 C/T cg23711669 chr6:146136114 FBXO30 0.67 11.09 0.52 1.66e-24 Lobe attachment (rater-scored or self-reported); CRC cis rs616402 0.527 rs2274985 chr1:10573867 G/A cg17425144 chr1:10567563 PEX14 0.58 13.35 0.59 8.66e-33 Breast size; CRC cis rs7264396 0.790 rs6060542 chr20:34249061 C/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.61 -10.31 -0.49 8.99e-22 Total cholesterol levels; CRC cis rs55823223 0.503 rs9906971 chr17:73848477 A/G cg10935138 chr17:73851978 WBP2 0.55 6.9 0.36 2.66e-11 Psoriasis; CRC cis rs597539 0.654 rs7107137 chr11:68623712 A/G cg06112835 chr11:68658793 MRPL21 0.44 6.86 0.35 3.51e-11 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs7402982 0.647 rs34038360 chr15:99201573 A/C cg03437748 chr15:99193247 IGF1R 0.59 7.92 0.4 3.72e-14 Birth weight; CRC cis rs1448094 0.533 rs7955135 chr12:86146350 G/A cg18827107 chr12:86230957 RASSF9 0.39 5.96 0.31 6.52e-9 Major depressive disorder; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg14629032 chr9:94185528 NFIL3 0.42 6.37 0.33 6.3e-10 Liver disease severity in Alagille syndrome; CRC cis rs4268898 0.662 rs56006260 chr2:24409903 A/G cg06627628 chr2:24431161 ITSN2 -0.86 -11.44 -0.53 9.42e-26 Asthma; CRC cis rs6456156 0.711 rs1855025 chr6:167537594 A/G cg05540913 chr6:167530185 CCR6 -0.41 -7.55 -0.38 4.2e-13 Primary biliary cholangitis; CRC cis rs4713118 0.516 rs6931858 chr6:28078411 A/T cg15786705 chr6:28176104 NA 0.71 8.77 0.44 1.01e-16 Parkinson's disease; CRC cis rs10876993 1.000 rs10876993 chr12:58062667 C/T cg15848620 chr12:58087721 OS9 -0.65 -9.27 -0.46 2.46e-18 Celiac disease or Rheumatoid arthritis; CRC cis rs9341808 0.667 rs2490244 chr6:80891112 A/T cg08355045 chr6:80787529 NA 0.38 6.45 0.33 4.1e-10 Sitting height ratio; CRC cis rs12541635 0.966 rs2029881 chr8:107002226 A/G cg10147462 chr8:107024639 NA 0.43 7.09 0.36 8.25e-12 Age of smoking initiation; CRC cis rs11764590 0.715 rs56289396 chr7:2091415 G/A cg02421172 chr7:1938701 MAD1L1 0.44 5.87 0.31 1.08e-8 Neuroticism; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg02084729 chr6:33589691 ITPR3 0.44 6.28 0.33 1.09e-9 Response to antipsychotic treatment; CRC cis rs2235642 0.750 rs763152 chr16:1658056 T/C cg26528668 chr16:1614120 IFT140 0.36 5.6 0.3 4.46e-8 Coronary artery disease; CRC cis rs9443645 0.869 rs10943609 chr6:79676328 A/T cg05283184 chr6:79620031 NA -0.6 -9.35 -0.46 1.35e-18 Intelligence (multi-trait analysis); CRC cis rs7959452 0.557 rs7980883 chr12:69778914 C/T cg14784868 chr12:69753453 YEATS4 0.84 14.68 0.63 7.14e-38 Blood protein levels; CRC cis rs79349575 0.685 rs1124829 chr17:46967797 C/A cg00947319 chr17:47005597 UBE2Z -0.33 -5.7 -0.3 2.6e-8 Type 2 diabetes; CRC cis rs10256972 0.504 rs2949178 chr7:1209925 T/C cg07092213 chr7:1199455 ZFAND2A -0.46 -6.77 -0.35 5.8200000000000003e-11 Longevity;Endometriosis; CRC cis rs4713118 0.786 rs200502 chr6:27788062 C/T cg12273811 chr6:28175739 NA 0.45 5.63 0.3 3.81e-8 Parkinson's disease; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg01372608 chr1:116185223 VANGL1 0.51 6.55 0.34 2.21e-10 Thyroid stimulating hormone; CRC cis rs57590327 0.508 rs4622918 chr3:81965382 A/G cg07356753 chr3:81810745 GBE1 -0.59 -7.89 -0.4 4.57e-14 Extraversion; CRC cis rs977987 0.806 rs4888389 chr16:75395228 T/C cg03315344 chr16:75512273 CHST6 0.53 8.89 0.44 4.14e-17 Dupuytren's disease; CRC cis rs801193 0.660 rs2659914 chr7:66156914 C/T cg11764359 chr7:65958608 NA 0.61 9.51 0.46 4.1e-19 Aortic root size; CRC trans rs7726839 0.540 rs72705097 chr5:655067 G/A cg25482853 chr8:67687455 SGK3 1.13 13.26 0.59 1.97e-32 Obesity-related traits; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg16414762 chr1:6845247 CAMTA1 0.39 6.42 0.33 4.64e-10 Liver disease severity in Alagille syndrome; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg13972460 chr20:1165703 C20orf46 0.34 6.07 0.32 3.59e-9 Liver disease severity in Alagille syndrome; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg13686799 chr11:60524194 MS4A15 0.29 6.04 0.32 4.06e-9 Liver disease severity in Alagille syndrome; CRC cis rs13118159 0.801 rs7664474 chr4:1329116 T/A cg20092199 chr4:1342459 KIAA1530 0.45 7.89 0.4 4.62e-14 Longevity; CRC cis rs950169 0.960 rs35159785 chr15:84804014 G/A cg17507749 chr15:85114479 UBE2QP1 0.75 11.08 0.52 1.85e-24 Schizophrenia; CRC cis rs7493 0.853 rs11770901 chr7:95054480 T/C cg21856205 chr7:94953877 PON1 -0.52 -6.62 -0.34 1.48e-10 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs875971 0.660 rs1860470 chr7:66103694 G/C cg25985355 chr7:65971099 NA 0.32 5.69 0.3 2.75e-8 Aortic root size; CRC cis rs2230307 0.536 rs684519 chr1:100604715 T/G cg24955406 chr1:100503596 HIAT1 -0.5 -6.02 -0.31 4.66e-9 Carotid intima media thickness; CRC cis rs9733 0.596 rs7529998 chr1:150662531 C/T cg17724175 chr1:150552817 MCL1 0.58 9.4 0.46 9.25e-19 Tonsillectomy; CRC cis rs8141529 0.732 rs5997408 chr22:29207915 G/A cg15103426 chr22:29168792 CCDC117 0.56 8.01 0.4 2.02e-14 Lymphocyte counts; CRC trans rs7267979 1.000 rs2387884 chr20:25379069 C/T cg17903999 chr18:56338584 MALT1 0.42 6.98 0.36 1.66e-11 Liver enzyme levels (alkaline phosphatase); CRC cis rs7043114 0.525 rs7850432 chr9:95130510 G/A cg14631576 chr9:95140430 CENPP -0.31 -5.9 -0.31 8.88e-9 Height; CRC cis rs28374715 0.662 rs10851403 chr15:41466087 T/G cg18705301 chr15:41695430 NDUFAF1 -0.9 -13.39 -0.59 6.12e-33 Ulcerative colitis; CRC cis rs7666738 0.830 rs28852677 chr4:99039509 T/G cg17366294 chr4:99064904 C4orf37 0.44 7.5 0.38 6.02e-13 Colonoscopy-negative controls vs population controls; CRC cis rs9560113 0.509 rs4771759 chr13:112209217 A/G cg10483660 chr13:112241077 NA -0.51 -9.54 -0.47 3.36e-19 Menarche (age at onset); CRC cis rs79387448 0.745 rs72993722 chr2:103124916 A/G cg00507830 chr2:103233733 NA 0.51 5.8 0.3 1.55e-8 Gut microbiota (bacterial taxa); CRC cis rs4689388 0.926 rs10010131 chr4:6292915 A/G cg14416269 chr4:6271139 WFS1 0.4 6.69 0.35 9.63e-11 Type 2 diabetes and other traits;Type 2 diabetes; CRC cis rs4750440 0.702 rs11258775 chr10:14029742 T/C cg00551146 chr10:14014579 FRMD4A 0.36 5.85 0.31 1.19e-8 Adiponectin levels; CRC cis rs4321325 0.733 rs79995601 chr2:127947452 T/C cg11380483 chr2:127933992 NA 0.53 6.72 0.35 7.96e-11 Protein C levels; CRC cis rs1401999 1.000 rs2176824 chr3:183654029 C/G cg05044414 chr3:183734942 ABCC5 0.48 8.33 0.42 2.17e-15 Anterior chamber depth; CRC cis rs7589728 0.514 rs74426843 chr2:88459388 C/T cg07952391 chr2:88470173 THNSL2 0.69 7.1 0.36 7.77e-12 Plasma clusterin levels; CRC cis rs758324 0.812 rs2159243 chr5:131133900 G/A cg25547332 chr5:131281432 NA 0.36 5.73 0.3 2.3e-8 Alzheimer's disease in APOE e4- carriers; CRC trans rs7395662 0.591 rs4882085 chr11:48504569 C/G cg15704280 chr7:45808275 SEPT13 -0.47 -6.67 -0.35 1.08e-10 HDL cholesterol; CRC cis rs6460942 1.000 rs6460942 chr7:12420989 T/C cg06484146 chr7:12443880 VWDE -0.75 -8.27 -0.42 3.26e-15 Coronary artery disease; CRC cis rs3820068 0.581 rs6692489 chr1:15928517 A/G cg13390004 chr1:15929781 NA 0.5 7.16 0.37 5.45e-12 Systolic blood pressure; CRC cis rs6502050 0.799 rs4789673 chr17:80123218 T/C cg22110888 chr17:80059540 CCDC57 0.4 6.38 0.33 5.96e-10 Life satisfaction; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg12427896 chr2:111880694 BCL2L11 0.48 6.36 0.33 6.75e-10 Thyroid stimulating hormone; CRC cis rs938554 0.735 rs12498742 chr4:9944052 A/G cg11266682 chr4:10021025 SLC2A9 -0.35 -5.84 -0.31 1.25e-8 Blood metabolite levels; CRC cis rs7959452 0.684 rs11177615 chr12:69754189 G/A cg14784868 chr12:69753453 YEATS4 0.81 13.64 0.6 6.79e-34 Blood protein levels; CRC cis rs6502050 0.835 rs7220639 chr17:80146866 G/A cg19223190 chr17:80058835 NA 0.38 6.09 0.32 3.15e-9 Life satisfaction; CRC cis rs6433857 0.594 rs17455575 chr2:181524487 G/A cg23363182 chr2:181467187 NA -0.47 -7.31 -0.37 2.05e-12 Body mass index; CRC cis rs7772486 0.790 rs9376968 chr6:146180364 T/C cg23711669 chr6:146136114 FBXO30 0.68 11.53 0.54 4.48e-26 Lobe attachment (rater-scored or self-reported); CRC cis rs6541297 1.000 rs4846909 chr1:230285372 G/A cg05784532 chr1:230284198 GALNT2 0.42 5.74 0.3 2.11e-8 Coronary artery disease; CRC cis rs1552244 0.882 rs6796419 chr3:10040812 G/A cg13047869 chr3:10149882 C3orf24 0.48 6.81 0.35 4.79e-11 Alzheimer's disease; CRC cis rs9372498 0.536 rs62422235 chr6:118971913 G/A cg22561889 chr6:118971681 C6orf204 0.49 5.86 0.31 1.13e-8 Diastolic blood pressure; CRC cis rs11168351 0.517 rs10875754 chr12:48557922 G/C cg24011408 chr12:48396354 COL2A1 0.43 6.35 0.33 7.25e-10 Bipolar disorder and schizophrenia; CRC cis rs10504229 1.000 rs66886949 chr8:58187613 A/G cg02290350 chr8:58132656 NA -0.42 -5.96 -0.31 6.62e-9 Developmental language disorder (linguistic errors); CRC cis rs9491140 0.514 rs11154227 chr6:124681816 G/A cg22366943 chr6:124882293 NKAIN2 0.53 7.56 0.38 4.16e-13 Neuroticism; CRC cis rs73200209 0.744 rs7133286 chr12:116483965 A/C cg01776926 chr12:116560359 MED13L -0.64 -7.68 -0.39 1.78e-13 Total body bone mineral density; CRC cis rs7927592 0.956 rs12365160 chr11:68250419 A/G cg16797656 chr11:68205561 LRP5 0.39 6.23 0.32 1.46e-9 Total body bone mineral density; CRC cis rs4689388 0.926 rs9998519 chr4:6292909 C/T cg25554036 chr4:6271136 WFS1 0.54 8.69 0.43 1.69e-16 Type 2 diabetes and other traits;Type 2 diabetes; CRC cis rs4423214 0.798 rs12224205 chr11:71180992 A/G cg05163923 chr11:71159392 DHCR7 -0.65 -7.79 -0.39 8.8e-14 Vitamin D levels; CRC cis rs2842992 0.714 rs2495278 chr6:160123674 G/A cg11366901 chr6:160182831 ACAT2 0.9 11.87 0.55 2.81e-27 Age-related macular degeneration (geographic atrophy); CRC cis rs6570726 0.935 rs447818 chr6:145868996 C/T cg05347473 chr6:146136440 FBXO30 0.4 6.29 0.33 9.84e-10 Lobe attachment (rater-scored or self-reported); CRC cis rs10782582 0.609 rs1770882 chr1:76411549 G/A cg10523679 chr1:76189770 ACADM -0.41 -5.96 -0.31 6.58e-9 Daytime sleep phenotypes; CRC cis rs720844 0.748 rs10928406 chr2:149329952 G/T cg09247360 chr2:149335327 NA -0.58 -6.12 -0.32 2.73e-9 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs7937682 0.564 rs11600652 chr11:111754368 A/T cg09085632 chr11:111637200 PPP2R1B 0.94 15.45 0.65 7.21e-41 Primary sclerosing cholangitis; CRC cis rs6570726 0.846 rs7773939 chr6:145927384 C/T cg13319975 chr6:146136371 FBXO30 0.44 6.58 0.34 1.89e-10 Lobe attachment (rater-scored or self-reported); CRC cis rs1150668 0.699 rs12214383 chr6:28223731 T/C cg25164649 chr6:28176230 NA -0.39 -5.74 -0.3 2.13e-8 Pubertal anthropometrics; CRC cis rs796364 0.806 rs76568708 chr2:200929531 C/T cg23649088 chr2:200775458 C2orf69 -0.59 -5.61 -0.3 4.29e-8 Schizophrenia; CRC cis rs2456568 0.933 rs1518577 chr11:93674907 C/T cg26875233 chr11:93583750 C11orf90 -0.34 -6.65 -0.34 1.21e-10 Response to serotonin reuptake inhibitors in major depressive disorder; CRC cis rs644799 1.000 rs534497 chr11:95562868 C/G cg03916912 chr11:95522834 CEP57;FAM76B 0.95 18.38 0.71 2.03e-52 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs9584850 0.834 rs17574378 chr13:99116384 T/C cg20750642 chr13:99100586 FARP1 -0.39 -5.64 -0.3 3.69e-8 Neuroticism; CRC cis rs1707322 0.827 rs6683274 chr1:46241638 T/G cg03146154 chr1:46216737 IPP 0.64 9.11 0.45 8.08e-18 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs2811415 0.597 rs9809087 chr3:127761128 G/A cg13719885 chr3:127795394 NA -0.39 -5.99 -0.31 5.56e-9 Lung function (FEV1/FVC); CRC cis rs1465370 0.800 rs62471721 chr7:130016470 G/A cg03229158 chr7:130009420 NA 0.48 6.92 0.36 2.3e-11 Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction);Waist circumference adjusted for BMI in active individuals;Waist circumference adjusted for body mass index; CRC cis rs6424115 1.000 rs12031592 chr1:24127864 A/C cg10978503 chr1:24200527 CNR2 0.45 8.05 0.41 1.51e-14 Immature fraction of reticulocytes; CRC cis rs61160187 0.549 rs12518404 chr5:60341996 T/C cg16298547 chr5:60138761 ELOVL7 -0.27 -5.74 -0.3 2.2e-8 Educational attainment (years of education);Educational attainment (college completion); CRC cis rs6831352 0.918 rs7670638 chr4:100059807 G/C cg13256891 chr4:100009986 ADH5 -0.66 -8.98 -0.44 2.17e-17 Alcohol dependence; CRC trans rs7615952 0.800 rs2062773 chr3:125639648 T/C cg00769240 chr8:12517080 NA -0.56 -6.78 -0.35 5.57e-11 Blood pressure (smoking interaction); CRC trans rs9929218 1.000 rs13334294 chr16:68809278 A/C cg04657470 chr2:198365150 HSPE1;HSPD1 -0.82 -11.54 -0.54 4.33e-26 Colorectal cancer; CRC cis rs34172651 0.917 rs200532 chr16:24756148 C/T cg04756594 chr16:24857601 SLC5A11 -0.23 -5.6 -0.3 4.48e-8 Intelligence (multi-trait analysis); CRC cis rs6717918 0.816 rs11901692 chr2:233149739 A/G ch.2.233013039R chr2:233304795 NA -0.48 -6.57 -0.34 1.93e-10 Height; CRC cis rs6499129 1.000 rs6499129 chr16:67458251 A/C cg26727032 chr16:67993705 SLC12A4 -0.52 -5.92 -0.31 8.25e-9 Waist-to-hip ratio adjusted for body mass index; CRC cis rs523522 0.673 rs643372 chr12:121022640 C/G cg27279351 chr12:120934652 DYNLL1 0.74 10.58 0.5 1.04e-22 High light scatter reticulocyte count; CRC cis rs875971 1.000 rs55962648 chr7:65625751 C/G cg11764359 chr7:65958608 NA -0.61 -9.86 -0.48 2.98e-20 Aortic root size; CRC cis rs4319547 0.620 rs12372756 chr12:122815130 A/G cg23029597 chr12:123009494 RSRC2 -0.51 -6.19 -0.32 1.76e-9 Body mass index; CRC cis rs7487075 0.797 rs12816358 chr12:46736646 A/G cg22049899 chr12:47219821 SLC38A4 0.33 6.13 0.32 2.49e-9 Itch intensity from mosquito bite; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg11644746 chr12:13043866 GPRC5A 0.46 6.47 0.34 3.47e-10 Response to antipsychotic treatment; CRC cis rs2732480 0.500 rs2450986 chr12:48661688 G/A cg21466736 chr12:48725269 NA -0.55 -8.18 -0.41 6.36e-15 Hemoglobin concentration;Red blood cell count;Hematocrit; CRC cis rs3761847 0.500 rs10760132 chr9:123739993 C/T cg09419670 chr9:123605666 PSMD5;LOC253039 0.4 6.23 0.32 1.43e-9 Rheumatoid arthritis; CRC cis rs7829975 0.533 rs13274028 chr8:8729193 A/C cg06636001 chr8:8085503 FLJ10661 0.44 6.45 0.34 3.97e-10 Mood instability; CRC cis rs6570726 0.764 rs367065 chr6:145882309 T/G cg05347473 chr6:146136440 FBXO30 0.4 6.1 0.32 2.95e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs7811142 1.000 rs4472444 chr7:100070758 T/C cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.62 8.09 0.41 1.19e-14 Platelet count; CRC cis rs28386778 1.000 rs2955241 chr17:61968113 G/C cg06873352 chr17:61820015 STRADA 0.73 12.87 0.58 5.38e-31 Prudent dietary pattern; CRC cis rs7249142 0.549 rs72997174 chr19:19294389 T/C cg08207377 chr19:19281140 LOC729991-MEF2B;MEF2B -0.38 -6.09 -0.32 3.15e-9 IgG glycosylation; CRC cis rs9341808 0.690 rs9343970 chr6:80881289 C/G cg08355045 chr6:80787529 NA 0.44 7.03 0.36 1.19e-11 Sitting height ratio; CRC cis rs1832871 0.711 rs62439861 chr6:158700531 A/G cg07165851 chr6:158734300 TULP4 0.6 7.59 0.39 3.38e-13 Height; CRC cis rs9549367 0.713 rs553316 chr13:113838015 A/G cg24300038 chr13:113819356 PROZ 0.51 6.69 0.35 9.53e-11 Platelet distribution width; CRC cis rs2204008 0.837 rs11168334 chr12:37961768 A/G cg13010199 chr12:38710504 ALG10B 0.45 5.7 0.3 2.65e-8 Bladder cancer; CRC trans rs17270561 1.000 rs12211184 chr6:25823774 G/A cg14063357 chr9:79793314 VPS13A;LOC100286938 0.6 6.19 0.32 1.83e-9 Iron status biomarkers; CRC cis rs1552244 1.000 rs2160869 chr3:10079255 G/A cg02579736 chr3:10068473 FANCD2;CIDECP 0.96 13.19 0.59 3.5e-32 Alzheimer's disease; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg23995395 chr4:83821786 THAP9 0.44 6.35 0.33 7.24e-10 Intelligence (multi-trait analysis); CRC cis rs4862750 0.914 rs11945845 chr4:187874136 T/C cg10295955 chr4:187884368 NA -0.99 -22.91 -0.78 4.2e-70 Lobe attachment (rater-scored or self-reported); CRC trans rs62103177 0.525 rs10438902 chr18:77745640 A/G cg05926928 chr17:57297772 GDPD1 -0.64 -7.42 -0.38 1.02e-12 Opioid sensitivity; CRC cis rs9341808 0.667 rs2505929 chr6:80834208 A/G cg08355045 chr6:80787529 NA 0.35 6.08 0.32 3.36e-9 Sitting height ratio; CRC trans rs79976124 0.879 rs77185357 chr6:66629070 G/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.76 9.54 0.47 3.31e-19 Type 2 diabetes; CRC cis rs10540 0.915 rs35389167 chr11:460765 A/G cg03576123 chr11:487126 PTDSS2 -1.01 -10.5 -0.5 2e-22 Body mass index; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg12721145 chr4:109571876 OSTC -0.41 -5.96 -0.31 6.4e-9 Myopia (pathological); CRC cis rs3820068 0.581 rs1122386 chr1:15946877 C/T cg24675056 chr1:15929824 NA 0.51 7.04 0.36 1.14e-11 Systolic blood pressure; CRC cis rs7827545 0.961 rs4909482 chr8:135564786 G/T cg07299736 chr8:135490787 ZFAT -0.37 -6.2 -0.32 1.73e-9 Hypertension (SNP x SNP interaction); CRC cis rs896854 0.714 rs572547 chr8:95966286 A/G cg16049864 chr8:95962084 TP53INP1 0.57 8.9 0.44 3.96e-17 Type 2 diabetes; CRC cis rs898097 0.585 rs9892342 chr17:80893029 C/T cg15664640 chr17:80829946 TBCD 0.48 8.04 0.41 1.67e-14 Breast cancer; CRC cis rs12594515 0.967 rs11854477 chr15:45998345 A/C cg06207120 chr15:45996521 NA 0.3 7.26 0.37 2.78e-12 Waist circumference;Weight; CRC cis rs6456156 0.742 rs2022000 chr6:167529611 A/G cg19688584 chr6:167529678 CCR6 -0.36 -6.45 -0.33 4.08e-10 Primary biliary cholangitis; CRC cis rs727563 0.562 rs5758458 chr22:42154132 G/A cg06481639 chr22:41940642 POLR3H 0.55 6.11 0.32 2.76e-9 Crohn's disease;Inflammatory bowel disease; CRC cis rs57221529 0.766 rs72703065 chr5:588123 C/A cg17948913 chr5:572064 NA 0.55 6.2 0.32 1.71e-9 Lung disease severity in cystic fibrosis; CRC cis rs10504229 0.953 rs72652908 chr8:58191324 G/A cg22535103 chr8:58192502 C8orf71 -0.82 -12.27 -0.56 9.63e-29 Developmental language disorder (linguistic errors); CRC cis rs294883 0.858 rs9457584 chr6:159722282 G/A cg14500486 chr6:159655392 FNDC1 -0.35 -5.76 -0.3 1.95e-8 Coronary artery disease; CRC cis rs7705042 0.865 rs7733850 chr5:141515564 C/T cg08523384 chr5:141488047 NDFIP1 -0.31 -5.68 -0.3 3.02e-8 Asthma; CRC cis rs11098499 0.722 rs7673476 chr4:120248683 C/T cg09307838 chr4:120376055 NA 0.59 9.1 0.45 8.83e-18 Corneal astigmatism; CRC cis rs7301826 0.651 rs4759517 chr12:131283698 G/A cg11011512 chr12:131303247 STX2 0.39 5.76 0.3 1.98e-8 Plasma plasminogen activator levels; CRC cis rs9611565 0.659 rs17367716 chr22:41913844 A/G cg06634786 chr22:41940651 POLR3H -0.71 -8.32 -0.42 2.44e-15 Vitiligo; CRC cis rs1577917 1.000 rs12190604 chr6:86716215 G/A cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.55 -6.91 -0.36 2.53e-11 Response to antipsychotic treatment; CRC trans rs4714291 0.802 rs911818 chr6:39988816 C/A cg02267698 chr19:7991119 CTXN1 -0.52 -7.19 -0.37 4.27e-12 Strep throat; CRC cis rs1448094 0.645 rs8181635 chr12:86465136 C/T cg02569458 chr12:86230093 RASSF9 -0.43 -7.18 -0.37 4.54e-12 Major depressive disorder; CRC cis rs916888 0.687 rs199456 chr17:44797919 C/T cg17911788 chr17:44343683 NA -0.66 -7.6 -0.39 3.17e-13 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs62064224 0.714 rs16967266 chr17:30632274 G/A cg09324608 chr17:30823087 MYO1D 0.35 6.21 0.32 1.64e-9 Schizophrenia; CRC cis rs11628318 0.802 rs2277471 chr14:103024387 A/C cg12046867 chr14:103022105 NA 0.71 9.86 0.48 2.91e-20 Platelet count; CRC cis rs2075371 1.000 rs1862050 chr7:133980999 T/C cg11752832 chr7:134001865 SLC35B4 0.48 7.36 0.38 1.51e-12 Mean platelet volume; CRC cis rs17826219 0.706 rs61643715 chr17:29057762 A/G cg13385521 chr17:29058706 SUZ12P 0.69 7.78 0.39 9.29e-14 Body mass index; CRC cis rs243505 0.660 rs10274701 chr7:148552456 C/T cg09806900 chr7:148480153 CUL1 0.52 6.58 0.34 1.89e-10 Inflammatory bowel disease;Crohn's disease; CRC cis rs9372498 0.536 rs9481825 chr6:118876092 C/T cg10217327 chr6:118973057 C6orf204 0.49 5.65 0.3 3.43e-8 Diastolic blood pressure; CRC cis rs4925386 0.802 rs6142735 chr20:60918087 G/C cg06026331 chr20:60912101 LAMA5 0.4 5.83 0.31 1.35e-8 Colorectal cancer;Colorectal cancer (SNP x SNP interaction); CRC cis rs4819052 0.851 rs2838848 chr21:46671017 A/G cg11663144 chr21:46675770 NA -0.86 -15.13 -0.64 1.24e-39 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs875971 1.000 rs1540651 chr7:65650121 C/T cg00343986 chr7:65444356 GUSB -0.45 -6.56 -0.34 2.11e-10 Aortic root size; CRC cis rs9611565 0.592 rs4822038 chr22:41958495 G/A cg06481639 chr22:41940642 POLR3H -0.57 -6.11 -0.32 2.77e-9 Vitiligo; CRC trans rs1728785 0.892 rs4783562 chr16:68562963 A/G cg04657470 chr2:198365150 HSPE1;HSPD1 0.72 8.24 0.41 4.21e-15 Ulcerative colitis; CRC cis rs375066 0.623 rs239949 chr19:44356627 C/T cg19542119 chr19:44331823 ZNF283 -0.41 -5.83 -0.31 1.31e-8 Breast cancer; CRC cis rs4713118 0.614 rs9380007 chr6:27660508 T/C cg12172441 chr6:28176163 NA 0.43 6.17 0.32 1.98e-9 Parkinson's disease; CRC cis rs2274273 0.870 rs3825616 chr14:55853288 G/C cg23234261 chr14:55582407 NA -0.29 -5.64 -0.3 3.62e-8 Protein biomarker; CRC cis rs3857067 1.000 rs7685048 chr4:95027784 C/T cg11021082 chr4:95130006 SMARCAD1 -0.41 -6.22 -0.32 1.55e-9 QT interval; CRC cis rs11105298 0.891 rs12369195 chr12:89934972 G/C cg08166232 chr12:89918718 WDR51B;GALNT4 -0.59 -7.27 -0.37 2.65e-12 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; CRC trans rs9858542 0.953 rs11706370 chr3:49441091 G/A cg21659725 chr3:3221576 CRBN -0.63 -8.62 -0.43 2.85e-16 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs13108904 0.901 rs13124847 chr4:1278206 A/G cg05665937 chr4:1216051 CTBP1 0.4 5.8 0.3 1.54e-8 Obesity-related traits; CRC cis rs422249 0.512 rs174561 chr11:61582708 T/C cg06781209 chr11:61594997 FADS2 -0.41 -5.91 -0.31 8.49e-9 Trans fatty acid levels; CRC cis rs769267 0.965 rs12460764 chr19:19431963 G/T cg20644253 chr19:19431407 KIAA0892;SF4 -0.41 -5.73 -0.3 2.33e-8 Tonsillectomy; CRC cis rs2882667 0.690 rs160404 chr5:138084269 A/G cg09476006 chr5:138032270 NA 0.56 9.8 0.48 4.45e-20 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs1153858 1.000 rs7181167 chr15:45686236 C/G cg21132104 chr15:45694354 SPATA5L1 0.6 8.6 0.43 3.27e-16 Homoarginine levels; CRC cis rs2797160 1.000 rs9401843 chr6:126004124 T/C cg05901451 chr6:126070800 HEY2 -0.41 -6.21 -0.32 1.61e-9 Endometrial cancer; CRC cis rs1865760 0.865 rs9467652 chr6:25959127 A/G cg17691542 chr6:26056736 HIST1H1C 0.55 8.4 0.42 1.36e-15 Height; CRC cis rs9611565 0.512 rs2050033 chr22:42159229 G/T cg17554472 chr22:41940697 POLR3H 0.55 5.61 0.3 4.29e-8 Vitiligo; CRC trans rs12599106 0.560 rs34151874 chr16:34989694 G/A cg03395511 chr6:291903 DUSP22 -0.64 -8.86 -0.44 5.02e-17 Menopause (age at onset); CRC cis rs4663866 1.000 rs13026475 chr2:239178455 T/C cg16914508 chr2:239161102 PER2 0.77 7.86 0.4 5.51e-14 Irritable bowel syndrome; CRC cis rs875971 0.545 rs6969224 chr7:65834998 T/G cg05627663 chr7:65219948 SNORA22;CCT6P1 0.6 7.68 0.39 1.88e-13 Aortic root size; CRC cis rs8180040 0.966 rs11130128 chr3:47486632 T/C cg27129171 chr3:47204927 SETD2 -0.6 -9.36 -0.46 1.24e-18 Colorectal cancer; CRC trans rs9291683 0.507 rs3796837 chr4:10011321 C/G cg26043149 chr18:55253948 FECH 0.49 7.28 0.37 2.55e-12 Bone mineral density; CRC cis rs425277 0.606 rs262653 chr1:2090095 T/G cg24578937 chr1:2090814 PRKCZ 0.39 7.02 0.36 1.25e-11 Height; CRC cis rs10883723 0.703 rs7898410 chr10:104245858 T/C cg22532475 chr10:104410764 TRIM8 -0.35 -6.48 -0.34 3.41e-10 Allergic disease (asthma, hay fever or eczema); CRC cis rs7762018 1.000 rs6923339 chr6:170128033 T/A cg24289452 chr6:170231220 NA -0.58 -6.58 -0.34 1.81e-10 Thiazide-induced adverse metabolic effects in hypertensive patients; CRC cis rs2760061 0.819 rs1745416 chr1:228204497 G/A cg01200585 chr1:228362443 C1orf69 0.38 5.65 0.3 3.47e-8 Diastolic blood pressure; CRC cis rs9916302 0.904 rs55689507 chr17:37404436 G/C cg07936489 chr17:37558343 FBXL20 -0.83 -12.72 -0.57 2.09e-30 Glomerular filtration rate (creatinine); CRC cis rs4555082 0.957 rs3000073 chr14:105729792 G/A cg10792982 chr14:105748885 BRF1 0.36 6.2 0.32 1.72e-9 Mean platelet volume;Platelet distribution width; CRC cis rs853679 0.517 rs9357065 chr6:28129580 T/C cg15845792 chr6:28175446 NA 1.04 13.94 0.61 4.93e-35 Depression; CRC trans rs7615952 0.932 rs13325495 chr3:125637416 T/G cg07211511 chr3:129823064 LOC729375 -1.2 -18.02 -0.7 5.43e-51 Blood pressure (smoking interaction); CRC cis rs72945132 0.638 rs11236127 chr11:70241536 G/C cg00319359 chr11:70116639 PPFIA1 0.61 6.39 0.33 5.62e-10 Coronary artery disease; CRC cis rs7618501 0.699 rs6446187 chr3:49907111 C/A cg05623727 chr3:50126028 RBM5 0.43 6.99 0.36 1.58e-11 Intelligence (multi-trait analysis); CRC cis rs853679 0.517 rs4713146 chr6:28111536 A/T cg02631126 chr6:28058918 ZSCAN12L1 0.29 5.91 0.31 8.38e-9 Depression; CRC cis rs968567 0.906 rs61897793 chr11:61599347 G/A cg21709803 chr11:61594965 FADS2 -0.62 -6.97 -0.36 1.7e-11 Blood metabolite levels;Rheumatoid arthritis;Vitiligo;Glycerophospholipid levels; CRC cis rs9389248 0.690 rs1028314 chr6:135255710 A/C cg22676075 chr6:135203613 NA -0.64 -9.98 -0.48 1.12e-20 High light scatter reticulocyte percentage of red cells; CRC cis rs17345786 0.798 rs1609159 chr3:101275902 A/C cg12386194 chr3:101231763 SENP7 0.45 6.12 0.32 2.63e-9 Colonoscopy-negative controls vs population controls; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg03513645 chr17:34891278 MYO19;PIGW 0.46 6.13 0.32 2.55e-9 Anxiety disorder; CRC trans rs9784649 0.760 rs17403440 chr5:25054004 C/T cg08600765 chr20:34638493 LOC647979 -0.69 -8.89 -0.44 4.14e-17 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs7178572 0.568 rs11636554 chr15:77608747 C/T cg22256960 chr15:77711686 NA -0.65 -9.6 -0.47 2.14e-19 Type 2 diabetes; CRC cis rs12142240 0.731 rs12385693 chr1:46818921 A/C cg00530320 chr1:46809349 NSUN4 0.59 7.94 0.4 3.15e-14 Menopause (age at onset); CRC cis rs6952808 0.964 rs10950400 chr7:1882470 C/T cg20295408 chr7:1910781 MAD1L1 -0.47 -6.5 -0.34 3.04e-10 Bipolar disorder and schizophrenia; CRC cis rs9291683 0.551 rs2276961 chr4:10022981 C/T cg00071950 chr4:10020882 SLC2A9 0.67 12.99 0.58 1.9e-31 Bone mineral density; CRC cis rs6594499 0.542 rs4530809 chr5:110462230 A/G cg04022379 chr5:110408740 TSLP 0.5 7.24 0.37 3.2e-12 Allergic disease (asthma, hay fever or eczema); CRC trans rs1351696 1 rs1351696 chr11:48382471 A/G cg03929089 chr4:120376271 NA -0.62 -6.08 -0.32 3.34e-9 D-dimer levels; CRC cis rs3789045 1.000 rs12046747 chr1:204593696 G/A cg17419461 chr1:204415978 PIK3C2B -0.49 -7.06 -0.36 1.02e-11 Educational attainment (college completion); CRC cis rs947211 1.000 rs947211 chr1:205752665 A/G cg26354017 chr1:205819088 PM20D1 0.42 5.91 0.31 8.72e-9 Parkinson's disease; CRC cis rs4713118 0.869 rs9295742 chr6:27702832 G/A cg03623178 chr6:28175578 NA 0.66 9.34 0.46 1.46e-18 Parkinson's disease; CRC cis rs951366 0.617 rs823074 chr1:205774839 T/C cg14159672 chr1:205819179 PM20D1 0.93 15.46 0.65 6.71e-41 Menarche (age at onset); CRC cis rs921968 0.565 rs1078803 chr2:219606538 A/C cg02176678 chr2:219576539 TTLL4 0.38 5.94 0.31 7.2e-9 Mean corpuscular hemoglobin concentration; CRC trans rs2018683 0.683 rs12538606 chr7:28969408 T/C cg19402173 chr7:128379420 CALU -0.42 -6.12 -0.32 2.67e-9 Response to irinotecan and platinum-based chemotherapy in non-small-cell lung cancer; CRC cis rs1707322 0.927 rs6690386 chr1:46253011 C/T cg03146154 chr1:46216737 IPP 0.6 8.49 0.42 6.99e-16 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs12291225 0.883 rs1864658 chr11:14256444 C/T cg19336497 chr11:14380999 RRAS2 0.36 5.78 0.3 1.75e-8 Sense of smell; CRC cis rs10876993 0.928 rs2640637 chr12:58077586 G/A cg15848620 chr12:58087721 OS9 -0.65 -9.09 -0.45 9.71e-18 Celiac disease or Rheumatoid arthritis; CRC cis rs2836974 0.623 rs7280326 chr21:40700408 A/G cg06238570 chr21:40685208 BRWD1 -0.83 -12.97 -0.58 2.42e-31 Cognitive function; CRC cis rs10504229 1.000 rs77857677 chr8:58170131 G/A cg01721255 chr8:58191610 C8orf71 0.49 6.17 0.32 2e-9 Developmental language disorder (linguistic errors); CRC trans rs561341 0.882 rs111484028 chr17:30287701 G/A cg27661571 chr11:113659931 NA -0.77 -9.59 -0.47 2.24e-19 Hip circumference adjusted for BMI; CRC trans rs17111396 0.627 rs61978744 chr14:81511484 T/C cg22745369 chr6:3517953 NA -0.43 -6.15 -0.32 2.19e-9 Uric acid levels; CRC cis rs881375 0.678 rs7021049 chr9:123683982 G/T cg14255062 chr9:123606675 PSMD5;LOC253039 0.38 6.09 0.32 3.19e-9 Rheumatoid arthritis; CRC cis rs262150 0.788 rs2657408 chr7:158782275 A/G cg04111992 chr7:158790115 NA -0.38 -6.21 -0.32 1.59e-9 Facial morphology (factor 20); CRC cis rs4713118 0.513 rs149954 chr6:28035246 G/A cg21251018 chr6:28226885 NKAPL 0.47 7.32 0.37 1.91e-12 Parkinson's disease; CRC cis rs561341 0.739 rs8070554 chr17:30216868 A/T cg12193833 chr17:30244370 NA 0.44 6.14 0.32 2.38e-9 Hip circumference adjusted for BMI; CRC cis rs2303745 0.622 rs1864113 chr19:17393504 G/C cg27101125 chr19:17392770 ANKLE1 -0.33 -5.75 -0.3 1.99e-8 Systemic lupus erythematosus; CRC cis rs9916302 0.904 rs602282 chr17:37433021 C/T cg03013999 chr17:37608204 MED1 0.48 7.33 0.37 1.82e-12 Glomerular filtration rate (creatinine); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg21159473 chr9:15510228 PSIP1 0.42 7.3 0.37 2.16e-12 Liver disease severity in Alagille syndrome; CRC cis rs853679 0.542 rs6934769 chr6:28090931 A/G cg15845792 chr6:28175446 NA 1.01 13.54 0.6 1.59e-33 Depression; CRC trans rs3942852 0.774 rs10838812 chr11:48186924 T/C cg03929089 chr4:120376271 NA -0.72 -9.04 -0.45 1.42e-17 Acute lymphoblastic leukemia (childhood); CRC cis rs5750830 0.594 rs1010170 chr22:39778327 C/T cg11247378 chr22:39784982 NA 0.42 6.92 0.36 2.34e-11 Intelligence (multi-trait analysis); CRC cis rs3126085 0.877 rs12116736 chr1:152167062 C/T cg09127314 chr1:152161683 NA 0.49 6.25 0.33 1.26e-9 Atopic dermatitis; CRC cis rs1005277 0.579 rs1740742 chr10:38518860 C/T cg25517755 chr10:38738941 LOC399744 -0.41 -5.92 -0.31 8.23e-9 Extrinsic epigenetic age acceleration; CRC cis rs8180040 0.603 rs9854790 chr3:47101306 T/G cg10298567 chr3:47292165 KIF9 -0.39 -6.15 -0.32 2.2e-9 Colorectal cancer; CRC cis rs908922 0.887 rs4596895 chr1:152528075 T/G cg23254163 chr1:152506842 NA 0.43 7.24 0.37 3.25e-12 Hair morphology; CRC cis rs2404602 0.647 rs11072607 chr15:76908529 C/T cg03037974 chr15:76606532 NA -0.51 -7.48 -0.38 6.7e-13 Blood metabolite levels; CRC cis rs10197940 0.662 rs4592848 chr2:152337822 G/A cg19508488 chr2:152266495 RIF1 0.58 8.08 0.41 1.29e-14 Lung cancer; CRC cis rs4731207 0.596 rs723443 chr7:124659301 A/T cg23710748 chr7:124431027 NA -0.38 -6.05 -0.32 3.97e-9 Cutaneous malignant melanoma; CRC cis rs12477438 0.798 rs6542849 chr2:99578493 G/C cg14399236 chr2:99771627 LIPT1;TSGA10 -0.7 -9.74 -0.47 7.45e-20 Chronic sinus infection; CRC cis rs6860806 0.661 rs28472559 chr5:131581611 G/A cg18301423 chr5:131593218 PDLIM4 0.36 6.77 0.35 5.77e-11 Breast cancer; CRC cis rs7552404 0.824 rs1251077 chr1:76189745 C/G cg03433033 chr1:76189801 ACADM -0.93 -17.42 -0.69 1.25e-48 Blood metabolite levels;Acylcarnitine levels; CRC cis rs4665809 0.549 rs17527979 chr2:26428132 A/G cg08067268 chr2:26466485 HADHB;HADHA -0.6 -7.07 -0.36 9.45e-12 Gut microbiome composition (summer); CRC cis rs365302 0.904 rs410879 chr6:159649747 T/C cg14500486 chr6:159655392 FNDC1 0.44 6.82 0.35 4.31e-11 Coronary heart disease; CRC cis rs4819143 0.517 rs439145 chr21:47373995 G/A cg14185626 chr21:47401492 COL6A1 -0.49 -5.65 -0.3 3.43e-8 Insulin resistance/response; CRC cis rs172166 0.561 rs149973 chr6:27983613 G/T cg23161317 chr6:28129485 ZNF389 0.38 5.67 0.3 3.16e-8 Cardiac Troponin-T levels; CRC cis rs7666738 0.752 rs35436270 chr4:99088280 G/A cg17366294 chr4:99064904 C4orf37 0.41 5.69 0.3 2.88e-8 Colonoscopy-negative controls vs population controls; CRC cis rs1707322 0.789 rs7540578 chr1:46252144 C/T cg03146154 chr1:46216737 IPP 0.62 8.99 0.44 1.92e-17 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC trans rs2294025 0.932 rs7836576 chr8:134164980 T/C cg19857114 chr3:176741225 TBL1XR1 -0.39 -6.13 -0.32 2.51e-9 Graves' disease; CRC cis rs12540874 0.728 rs3807563 chr7:50566390 C/T cg14593290 chr7:50529359 DDC -0.47 -6.56 -0.34 2.11e-10 Systemic sclerosis; CRC cis rs8072100 0.713 rs9899859 chr17:45513049 A/G cg08085267 chr17:45401833 C17orf57 -0.58 -8.68 -0.43 1.92e-16 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs897984 0.542 rs7197717 chr16:31083075 A/C cg02466173 chr16:30829666 NA -0.6 -9.33 -0.46 1.56e-18 Dementia with Lewy bodies; CRC cis rs6061231 0.556 rs6121571 chr20:60977323 T/G cg24112000 chr20:60950667 NA -0.58 -9.91 -0.48 1.93e-20 Colorectal cancer; CRC trans rs4263408 0.934 rs9683743 chr4:39703194 A/C cg08352292 chr17:27503756 MYO18A -0.42 -6.27 -0.33 1.13e-9 Plasma amyloid beta peptide concentrations (ABx-40); CRC cis rs7527798 0.592 rs12022909 chr1:207859743 T/C cg09232269 chr1:207846808 CR1L -0.43 -7.15 -0.37 5.82e-12 Erythrocyte sedimentation rate; CRC cis rs977987 0.806 rs12051136 chr16:75435731 G/T cg03315344 chr16:75512273 CHST6 0.54 9.08 0.45 1.01e-17 Dupuytren's disease; CRC cis rs79387448 0.745 rs76720903 chr2:103162826 G/A cg09003973 chr2:102972529 NA 0.73 8.01 0.4 1.97e-14 Gut microbiota (bacterial taxa); CRC cis rs9896052 0.559 rs7220850 chr17:73436994 T/C cg21038819 chr17:73507788 CASKIN2 0.6 5.61 0.3 4.4e-8 Sight-threatening diabetic retinopathy in type 2 diabetes; CRC cis rs4731207 0.535 rs1351471 chr7:124672015 A/T cg23710748 chr7:124431027 NA -0.39 -6.2 -0.32 1.72e-9 Cutaneous malignant melanoma; CRC cis rs5167 0.506 rs35193317 chr19:45470344 C/T cg09555818 chr19:45449301 APOC2 -0.33 -5.75 -0.3 2.08e-8 Blood protein levels; CRC cis rs6121246 0.609 rs6089075 chr20:30392884 A/G cg13852791 chr20:30311386 BCL2L1 0.76 14.84 0.63 1.71e-38 Mean corpuscular hemoglobin; CRC trans rs7937682 0.924 rs513425 chr11:111504861 C/T cg18187862 chr3:45730750 SACM1L 0.48 6.88 0.35 3.04e-11 Primary sclerosing cholangitis; CRC cis rs73206853 0.841 rs7956963 chr12:110947783 G/A cg12870014 chr12:110450643 ANKRD13A 0.73 7.86 0.4 5.56e-14 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC cis rs950169 0.922 rs62028133 chr15:84919375 A/C cg11189052 chr15:85197271 WDR73 0.64 8.98 0.44 2.11e-17 Schizophrenia; CRC cis rs6456156 0.846 rs10946211 chr6:167515489 G/A cg07513332 chr6:167530253 CCR6 -0.41 -7.13 -0.37 6.45e-12 Primary biliary cholangitis; CRC cis rs9611565 0.512 rs5751153 chr22:42156561 T/C cg03806693 chr22:41940476 POLR3H 1.09 13.38 0.59 6.59e-33 Vitiligo; CRC cis rs514406 0.793 rs12402415 chr1:53218539 G/T cg27535305 chr1:53392650 SCP2 0.38 7.1 0.36 7.9e-12 Monocyte count; CRC cis rs1375194 0.582 rs4670735 chr2:33801456 C/T cg04131969 chr2:33951647 MYADML -0.52 -7.54 -0.38 4.52e-13 Response to antidepressants in depression; CRC cis rs6502050 0.805 rs7406137 chr17:80084465 T/C cg19223190 chr17:80058835 NA -0.42 -6.61 -0.34 1.56e-10 Life satisfaction; CRC cis rs9303280 0.773 rs11078925 chr17:38025208 T/C cg11212589 chr17:38028394 ZPBP2 0.42 7.8 0.4 8.14e-14 Self-reported allergy; CRC cis rs6502050 0.835 rs7213172 chr17:80085703 G/T cg22110888 chr17:80059540 CCDC57 -0.41 -6.39 -0.33 5.58e-10 Life satisfaction; CRC cis rs7552404 0.924 rs12136754 chr1:76230232 C/A cg22875332 chr1:76189707 ACADM 0.8 11.8 0.55 4.89e-27 Blood metabolite levels;Acylcarnitine levels; CRC cis rs9486719 0.857 rs2983897 chr6:97033780 C/T cg18709589 chr6:96969512 KIAA0776 -0.49 -6.38 -0.33 6.05e-10 Migraine;Coronary artery disease; CRC cis rs1799949 1.000 rs1960605 chr17:41305397 C/T cg05368731 chr17:41323189 NBR1 0.69 10.52 0.5 1.73e-22 Menopause (age at onset); CRC cis rs2153535 0.580 rs1414350 chr6:8472331 C/T cg21535247 chr6:8435926 SLC35B3 0.5 7.53 0.38 4.89e-13 Motion sickness; CRC cis rs597583 0.715 rs1940040 chr11:117393294 G/C cg27161313 chr11:117392002 DSCAML1 -0.47 -6.12 -0.32 2.62e-9 Putamen volume; CRC cis rs2635047 0.656 rs1355594 chr18:44763994 T/G cg19077165 chr18:44547161 KATNAL2 -0.41 -6.04 -0.32 4.23e-9 Educational attainment; CRC cis rs13191362 0.935 rs67889271 chr6:163045753 T/G cg21926612 chr6:163149169 PACRG;PARK2 0.96 12.13 0.56 3.18e-28 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs8077889 0.957 rs17742929 chr17:41891437 C/T cg16892393 chr17:41919603 NA 0.55 7.95 0.4 2.94e-14 Triglycerides; CRC cis rs9486719 1.000 rs11752584 chr6:96884952 C/A cg06623918 chr6:96969491 KIAA0776 -0.81 -9.51 -0.46 4.17e-19 Migraine;Coronary artery disease; CRC cis rs7208859 0.524 rs11653098 chr17:29122501 C/T cg13385521 chr17:29058706 SUZ12P 0.74 8.44 0.42 9.97e-16 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs9902453 0.845 rs2617865 chr17:28049804 G/T cg26525008 chr17:28256777 EFCAB5;SSH2 -0.58 -8.73 -0.43 1.32e-16 Coffee consumption (cups per day); CRC cis rs644799 1.000 rs543530 chr11:95545170 A/G cg25478527 chr11:95522999 CEP57;FAM76B 0.51 7.69 0.39 1.68e-13 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs939574 0.790 rs2276635 chr2:220087441 T/C cg00496455 chr2:220118770 TUBA4A;TUBA4B 0.9 8.26 0.41 3.61e-15 Platelet distribution width; CRC cis rs896854 0.684 rs10099059 chr8:95986972 G/C cg23172400 chr8:95962367 TP53INP1 -0.46 -7.81 -0.4 7.78e-14 Type 2 diabetes; CRC trans rs7615952 0.543 rs4645102 chr3:125424441 A/G cg03844506 chr4:4109441 NA -0.51 -7.62 -0.39 2.75e-13 Blood pressure (smoking interaction); CRC cis rs2836950 0.565 rs2836943 chr21:40592611 C/T cg11890956 chr21:40555474 PSMG1 -0.69 -10.38 -0.5 4.9e-22 Menarche (age at onset); CRC cis rs7618915 0.547 rs35211965 chr3:52685305 C/G cg18404041 chr3:52824283 ITIH1 -0.44 -9.03 -0.45 1.49e-17 Bipolar disorder; CRC trans rs6598955 0.572 rs6598951 chr1:26592714 G/T cg07461501 chr17:79650226 HGS;ARL16 -0.51 -5.99 -0.31 5.58e-9 Obesity-related traits; CRC trans rs3807766 0.581 rs6954104 chr7:77693258 C/T cg04073608 chr11:65268100 MALAT1 -0.46 -6.66 -0.34 1.14e-10 3-hydroxypropylmercapturic acid levels in smokers; CRC cis rs9393692 0.599 rs9358920 chr6:26292029 C/T cg00631329 chr6:26305371 NA -0.55 -9.4 -0.46 9.9e-19 Educational attainment; CRC cis rs6866344 0.697 rs17184302 chr5:178127676 C/T cg10224037 chr5:178157518 ZNF354A 0.78 11.45 0.53 9.28e-26 Neutrophil percentage of white cells; CRC cis rs7680126 0.596 rs10939835 chr4:10313750 A/G cg00071950 chr4:10020882 SLC2A9 -0.52 -6.55 -0.34 2.24e-10 Urate levels in lean individuals;Urate levels in overweight individuals;Urate levels in obese individuals; CRC cis rs11105298 0.786 rs3803128 chr12:89860319 C/A cg00757033 chr12:89920650 WDR51B 0.37 6.13 0.32 2.52e-9 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; CRC cis rs2213920 0.679 rs4979534 chr9:118211159 T/C cg13918206 chr9:118159781 DEC1 0.59 5.8 0.3 1.58e-8 Docetaxel-induced peripheral neuropathy in metastatic castrate-resistant prostate cancer; CRC cis rs12753569 0.748 rs1340689 chr1:76506409 T/A cg00791851 chr1:76518896 NA 0.36 6.54 0.34 2.34e-10 Personality dimensions; CRC cis rs933688 1.000 rs6867091 chr5:90734333 C/G cg26981201 chr5:90679533 LOC100129716;ARRDC3 0.96 16.87 0.68 1.85e-46 Smoking behavior; CRC trans rs8002861 0.664 rs9533662 chr13:44435988 T/A cg12856521 chr11:46389249 DGKZ 0.44 7.26 0.37 2.78e-12 Leprosy; CRC cis rs9303401 0.580 rs34076823 chr17:57114497 C/G cg02118635 chr17:56770003 RAD51C;TEX14 0.67 8.23 0.41 4.3e-15 Cognitive test performance; CRC cis rs10504229 0.683 rs67035623 chr8:58139963 G/T cg21724239 chr8:58056113 NA 0.49 6.81 0.35 4.75e-11 Developmental language disorder (linguistic errors); CRC cis rs9296092 0.560 rs62407561 chr6:33528103 T/C cg13560919 chr6:33536144 NA -0.44 -6.28 -0.33 1.09e-9 Age at smoking initiation in chronic obstructive pulmonary disease; CRC cis rs875971 1.000 rs35149210 chr7:65929925 T/C cg18876405 chr7:65276391 NA 0.52 8.85 0.44 5.32e-17 Aortic root size; CRC cis rs1190552 0.846 rs3783381 chr14:102965435 A/G cg18135206 chr14:102964638 TECPR2 0.52 6.18 0.32 1.88e-9 Blood protein levels; CRC cis rs11608355 0.545 rs35018715 chr12:109893134 T/C cg05360138 chr12:110035743 NA 0.77 8.7 0.43 1.65e-16 Neuroticism; CRC cis rs68170813 0.559 rs11769527 chr7:106912948 C/T cg02696742 chr7:106810147 HBP1 -0.6 -6.65 -0.34 1.25e-10 Coronary artery disease; CRC cis rs2832191 0.967 rs2898160 chr21:30487496 A/G cg24692254 chr21:30365293 RNF160 -0.65 -11.2 -0.53 7.06e-25 Dental caries; CRC trans rs3780486 0.801 rs10971424 chr9:33138775 T/C cg04842962 chr6:43655489 MRPS18A 1.17 25.84 0.82 3.41e-81 IgG glycosylation; CRC cis rs2786111 0.965 rs664767 chr1:197280295 A/C cg13682187 chr1:196946512 CFHR5 0.29 5.71 0.3 2.47e-8 Lupus nephritis in systemic lupus erythematosus; CRC cis rs4819052 0.819 rs8134084 chr21:46693295 G/A cg11663144 chr21:46675770 NA -0.85 -14.55 -0.63 2.21e-37 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs8072100 0.967 rs4794058 chr17:45597098 C/T cg25173405 chr17:45401733 C17orf57 0.43 6.75 0.35 6.58e-11 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs6502050 0.835 rs11654584 chr17:80079435 A/T cg19223190 chr17:80058835 NA 0.43 6.73 0.35 7.49e-11 Life satisfaction; CRC cis rs6785206 0.803 rs6774512 chr3:128415868 C/T cg16766828 chr3:128327626 NA -0.51 -5.65 -0.3 3.42e-8 Lymphocyte percentage of white cells; CRC cis rs6502050 0.871 rs8080366 chr17:80067298 A/G cg25804541 chr17:80189381 SLC16A3 0.31 5.73 0.3 2.21e-8 Life satisfaction; CRC cis rs7586879 1.000 rs12713419 chr2:25121853 G/A cg22495460 chr2:25135724 ADCY3 -0.82 -13.76 -0.6 2.5e-34 Body mass index; CRC cis rs9611565 0.765 rs202663 chr22:41812819 T/C cg06634786 chr22:41940651 POLR3H 0.6 6.95 0.36 1.93e-11 Vitiligo; CRC cis rs34172651 0.917 rs1465422 chr16:24772486 C/T cg00339695 chr16:24857497 SLC5A11 0.28 6.6 0.34 1.61e-10 Intelligence (multi-trait analysis); CRC cis rs12692738 0.526 rs355873 chr2:165632464 T/C cg03182029 chr2:165697222 COBLL1 0.5 5.86 0.31 1.11e-8 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);Waist-to-hip ratio adjusted for BMI in non-smokers;Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction);Waist-to-hip ratio adjusted for body mass index; CRC cis rs9796 0.621 rs2899013 chr15:41492283 G/T cg18705301 chr15:41695430 NDUFAF1 -0.42 -6.94 -0.36 2.07e-11 Menopause (age at onset); CRC cis rs10540 0.558 rs12806062 chr11:501429 G/A cg08200582 chr11:442649 ANO9 -0.71 -7.0 -0.36 1.41e-11 Body mass index; CRC trans rs208520 0.690 rs207112 chr6:66792092 C/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.08 -15.36 -0.65 1.56e-40 Exhaled nitric oxide output; CRC cis rs2153535 0.869 rs11962457 chr6:8375855 A/T cg07606381 chr6:8435919 SLC35B3 -0.43 -6.25 -0.33 1.28e-9 Motion sickness; CRC trans rs11098499 0.863 rs13140409 chr4:120503460 A/G cg25214090 chr10:38739885 LOC399744 0.67 10.3 0.49 9.23e-22 Corneal astigmatism; CRC cis rs11122272 0.705 rs2491411 chr1:231533448 C/G cg06096015 chr1:231504339 EGLN1 0.4 6.0 0.31 5.13e-9 Hemoglobin concentration; CRC cis rs59104589 0.617 rs73002114 chr2:242280924 G/A cg19488206 chr2:242435732 STK25 0.47 6.8 0.35 4.97e-11 Fibrinogen levels; CRC cis rs7666738 0.830 rs7662114 chr4:99019985 A/G cg05340658 chr4:99064831 C4orf37 0.61 9.51 0.46 4.05e-19 Colonoscopy-negative controls vs population controls; CRC cis rs853679 0.550 rs1233707 chr6:28172953 G/A cg21251018 chr6:28226885 NKAPL 0.47 6.66 0.34 1.12e-10 Depression; CRC cis rs11723261 0.582 rs11248005 chr4:166615 C/T cg12746427 chr4:53362 ZNF718;ZNF595 0.49 6.64 0.34 1.28e-10 Immune response to smallpox vaccine (IL-6); CRC trans rs1455244 0.700 rs7229302 chr18:11508904 G/T cg11813246 chr1:42846740 RIMKLA 0.44 6.92 0.36 2.31e-11 Schizophrenia; CRC cis rs3204270 0.810 rs8077959 chr17:79670122 G/A cg09655341 chr17:79618100 PDE6G 0.55 6.53 0.34 2.57e-10 Dental caries; CRC cis rs3824347 0.839 rs3758184 chr9:77568392 C/G cg01251476 chr9:77566080 C9orf40 0.39 6.05 0.32 3.87e-9 Urinary magnesium-to-creatinine ratio; CRC cis rs853679 0.517 rs9357065 chr6:28129580 T/C cg03623178 chr6:28175578 NA 0.99 12.74 0.57 1.72e-30 Depression; CRC cis rs2635047 0.777 rs9944807 chr18:44788908 A/G cg19077165 chr18:44547161 KATNAL2 -0.39 -5.95 -0.31 6.9e-9 Educational attainment; CRC cis rs62458065 1.000 rs10275978 chr7:32466719 G/T cg20159608 chr7:32802032 NA -0.5 -6.35 -0.33 7.34e-10 Metabolite levels (HVA/MHPG ratio); CRC cis rs7402982 0.625 rs4966011 chr15:99204006 G/A cg03437748 chr15:99193247 IGF1R 0.58 7.84 0.4 6.14e-14 Birth weight; CRC cis rs2836974 0.899 rs68004583 chr21:40659587 T/C cg11644478 chr21:40555479 PSMG1 0.8 12.54 0.57 9.7e-30 Cognitive function; CRC cis rs853679 0.517 rs1904840 chr6:28108232 C/T cg18032046 chr6:28092343 ZSCAN16 -0.51 -5.93 -0.31 7.47e-9 Depression; CRC trans rs561341 0.941 rs2428336 chr17:30290577 T/C cg20587970 chr11:113659929 NA -1.2 -17.22 -0.69 8.08e-48 Hip circumference adjusted for BMI; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg07227728 chr7:131012528 MKLN1 0.38 6.41 0.33 5.04e-10 Liver disease severity in Alagille syndrome; CRC trans rs561341 0.882 rs16967101 chr17:30377162 A/G cg27661571 chr11:113659931 NA -0.7 -8.87 -0.44 4.79e-17 Hip circumference adjusted for BMI; CRC cis rs875971 1.000 rs2087647 chr7:65593188 C/A cg18876405 chr7:65276391 NA -0.52 -8.94 -0.44 2.87e-17 Aortic root size; CRC cis rs9682041 0.627 rs3772172 chr3:170077713 C/T cg11886554 chr3:170076028 SKIL -0.61 -7.37 -0.38 1.39e-12 Glomerular filtration rate in non diabetics (creatinine);Glomerular filtration rate (creatinine); CRC cis rs7909074 1.000 rs1408814 chr10:45399088 A/G cg04218760 chr10:45406644 TMEM72 -0.34 -9.66 -0.47 1.35e-19 Mean corpuscular volume; CRC cis rs798554 0.959 rs798558 chr7:2758935 T/G cg19346786 chr7:2764209 NA -0.42 -7.36 -0.38 1.46e-12 Height; CRC cis rs7408868 0.706 rs2238642 chr19:15282237 T/C cg14696996 chr19:15285081 NOTCH3 0.54 6.0 0.31 5.25e-9 Pulse pressure; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg19272713 chr11:66247337 DPP3 0.48 6.76 0.35 6.25e-11 Response to antipsychotic treatment; CRC cis rs2933343 0.661 rs2630259 chr3:128606322 C/T cg11901034 chr3:128598214 ACAD9 -0.55 -7.76 -0.39 1.06e-13 IgG glycosylation; CRC cis rs2303745 0.622 rs1864113 chr19:17393504 G/C cg02221750 chr19:17393354 ANKLE1 -0.43 -6.58 -0.34 1.82e-10 Systemic lupus erythematosus; CRC cis rs13256369 0.755 rs12680167 chr8:8562467 A/G cg18904891 chr8:8559673 CLDN23 0.54 7.14 0.37 5.84e-12 Obesity-related traits; CRC cis rs1018836 0.923 rs13262354 chr8:91635731 G/A cg16814680 chr8:91681699 NA -0.73 -11.23 -0.53 5.48e-25 Ejection fraction in Tripanosoma cruzi seropositivity; CRC cis rs1949733 0.656 rs2631762 chr4:8423122 A/T cg13073564 chr4:8508604 NA -0.45 -6.87 -0.35 3.13e-11 Response to antineoplastic agents; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg07817097 chr1:179851575 TOR1AIP1 -0.42 -6.0 -0.31 5.19e-9 Myopia (pathological); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg05010219 chr10:134210111 PWWP2B 0.45 7.38 0.38 1.3e-12 Liver disease severity in Alagille syndrome; CRC trans rs688181 0.646 rs6903041 chr6:158111700 C/G cg11843673 chr2:239699222 NA 0.37 6.0 0.31 5.12e-9 Platelet distribution width; CRC cis rs6951245 0.554 rs58210047 chr7:1149381 G/A cg18297960 chr7:1142765 C7orf50 -0.42 -5.72 -0.3 2.39e-8 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs9486715 0.867 rs2499774 chr6:97006581 C/G cg06623918 chr6:96969491 KIAA0776 -1.04 -21.0 -0.76 1.07e-62 Headache; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg26459430 chr19:680063 FSTL3 0.4 6.64 0.34 1.28e-10 Liver disease severity in Alagille syndrome; CRC cis rs10971721 0.822 rs56274755 chr9:33934271 T/C cg13495928 chr9:33750294 PRSS3 0.56 5.95 0.31 6.96e-9 Body mass index; CRC trans rs3942852 0.868 rs7118226 chr11:48106267 T/G cg03929089 chr4:120376271 NA -0.51 -6.16 -0.32 2.11e-9 Acute lymphoblastic leukemia (childhood); CRC cis rs1707322 0.717 rs3014245 chr1:46086913 C/T cg06784218 chr1:46089804 CCDC17 -0.66 -12.17 -0.56 2.14e-28 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs926938 0.841 rs11588144 chr1:115239355 G/A cg12756093 chr1:115239321 AMPD1 -0.79 -13.75 -0.6 2.63e-34 Autism; CRC cis rs2440129 0.611 rs1126667 chr17:6902760 C/T cg25987502 chr17:6899865 ALOX12 -0.32 -5.83 -0.31 1.36e-8 Tonsillectomy; CRC cis rs926938 0.505 rs360629 chr1:115414733 A/G cg12756093 chr1:115239321 AMPD1 0.56 8.21 0.41 5.11e-15 Autism; CRC cis rs832540 0.669 rs832538 chr5:56200016 C/T cg18230493 chr5:56204884 C5orf35 -0.49 -7.2 -0.37 4.19e-12 Coronary artery disease; CRC cis rs7811142 0.562 rs7786844 chr7:99934008 T/G cg07160278 chr7:100027354 MEPCE;ZCWPW1 0.97 13.48 0.6 2.73e-33 Platelet count; CRC cis rs7586879 0.616 rs10206196 chr2:25137323 T/C cg04586622 chr2:25135609 ADCY3 -0.55 -10.13 -0.49 3.56e-21 Body mass index; CRC trans rs7647973 0.593 rs1799844 chr3:49847642 G/A cg21665057 chr3:196295764 WDR53;FBXO45 0.59 6.24 0.33 1.31e-9 Menarche (age at onset); CRC cis rs832540 0.629 rs6888317 chr5:56093307 A/G cg03609598 chr5:56110824 MAP3K1 0.44 5.88 0.31 1.03e-8 Coronary artery disease; CRC cis rs9372498 0.536 rs12333080 chr6:118845410 A/C cg18833306 chr6:118973337 C6orf204 0.45 6.01 0.31 4.81e-9 Diastolic blood pressure; CRC cis rs780096 0.506 rs56076827 chr2:27676287 A/T cg17158414 chr2:27665306 KRTCAP3 -0.29 -6.18 -0.32 1.9e-9 Total body bone mineral density; CRC trans rs2898857 0.524 rs2960172 chr17:47379581 G/A cg11430096 chr6:110968061 CDK19 0.54 8.06 0.41 1.47e-14 Cancer; CRC cis rs3736594 0.918 rs9967838 chr2:27968454 A/C cg27432699 chr2:27873401 GPN1 -0.63 -8.64 -0.43 2.52e-16 Fasting blood glucose;Fasting blood glucose (BMI interaction); CRC cis rs832540 0.931 rs832536 chr5:56212595 C/T cg20203395 chr5:56204925 C5orf35 -0.41 -5.63 -0.3 3.93e-8 Coronary artery disease; CRC cis rs2302190 0.882 rs9903050 chr17:56636908 T/C cg12560992 chr17:57184187 TRIM37 0.53 6.15 0.32 2.28e-9 Vitamin D levels; CRC cis rs9929218 0.817 rs3114400 chr16:68719430 C/T cg02972257 chr16:68554789 NA 0.51 6.21 0.32 1.62e-9 Colorectal cancer; CRC cis rs7224737 1.000 rs2240010 chr17:40278081 T/A cg00647820 chr17:40259828 DHX58 -0.46 -6.58 -0.34 1.86e-10 Fibrinogen levels; CRC cis rs8064299 0.597 rs4789097 chr17:72781208 C/T cg25054828 chr17:72772726 NAT9;TMEM104 -0.85 -14.9 -0.63 9.69e-39 Monocyte count; CRC cis rs7552404 0.731 rs12078299 chr1:76365764 T/A cg22875332 chr1:76189707 ACADM 0.65 7.88 0.4 4.79e-14 Blood metabolite levels;Acylcarnitine levels; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg14777817 chr13:80055594 NDFIP2 -0.41 -5.99 -0.31 5.39e-9 Myopia (pathological); CRC trans rs10050311 0.698 rs67867077 chr4:87643746 G/A cg00004207 chr2:38977301 SFRS7 0.51 6.16 0.32 2.08e-9 Insulin-related traits; CRC cis rs4481887 0.508 rs4916115 chr1:248383316 T/G cg00666640 chr1:248458726 OR2T12 0.37 6.31 0.33 8.95e-10 Common traits (Other); CRC cis rs28386778 0.897 rs9915552 chr17:61869095 G/A cg23090583 chr17:61904693 PSMC5;FTSJ3 1.05 20.28 0.75 7.02e-60 Prudent dietary pattern; CRC cis rs644799 0.648 rs1255181 chr11:95472148 T/C cg03916912 chr11:95522834 CEP57;FAM76B 0.56 8.67 0.43 2e-16 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs9916302 0.904 rs801426 chr17:37441109 C/T cg03013999 chr17:37608204 MED1 -0.47 -7.34 -0.38 1.68e-12 Glomerular filtration rate (creatinine); CRC cis rs4728302 0.583 rs58955798 chr7:133158420 C/T cg10665199 chr7:133106180 EXOC4 0.67 10.41 0.5 4.15e-22 Intelligence;Intelligence (multi-trait analysis); CRC cis rs6908034 0.607 rs80355837 chr6:19808343 C/G cg02682789 chr6:19804855 NA 0.78 6.83 0.35 4.16e-11 Endometriosis;Deep ovarian and/or rectovaginal disease with dense adhesions; CRC cis rs7584330 0.666 rs937386 chr2:238364039 C/T cg11271282 chr2:238384023 NA 0.48 5.61 0.3 4.25e-8 Prostate cancer; CRC cis rs425277 0.606 rs424079 chr1:2071340 C/A cg04315214 chr1:2043799 PRKCZ 0.39 6.74 0.35 7.09e-11 Height; CRC cis rs78456975 0.527 rs10206020 chr2:1557927 A/G cg12573674 chr2:1569213 NA -0.81 -10.49 -0.5 2.06e-22 Placebo response in major depressive disorder (% change in symptom score); CRC cis rs72945132 0.714 rs115143889 chr11:70150122 G/T cg00319359 chr11:70116639 PPFIA1 0.65 6.53 0.34 2.47e-10 Coronary artery disease; CRC cis rs853679 0.760 rs9368563 chr6:28208558 A/G cg03623178 chr6:28175578 NA 0.74 7.82 0.4 7.43e-14 Depression; CRC cis rs7107174 0.901 rs7937277 chr11:78114977 C/G cg12700464 chr11:78128424 GAB2 -0.53 -6.03 -0.32 4.53e-9 Testicular germ cell tumor; CRC trans rs951252 0.504 rs11734405 chr4:146081096 C/T cg14479329 chr6:167370587 RNASET2 0.49 6.31 0.33 9.08e-10 Hip circumference; CRC cis rs11148252 0.840 rs4369550 chr13:52744910 A/G cg12458913 chr13:53173898 NA 0.54 8.47 0.42 8.35e-16 Lewy body disease; CRC cis rs6502050 0.835 rs10163482 chr17:80110394 C/A cg02741985 chr17:80059408 CCDC57 0.43 7.15 0.37 5.66e-12 Life satisfaction; CRC cis rs4713118 0.662 rs9468277 chr6:28028390 C/A cg21251018 chr6:28226885 NKAPL 0.46 6.53 0.34 2.56e-10 Parkinson's disease; CRC trans rs629535 0.814 rs506931 chr8:70068129 T/G cg21567404 chr3:27674614 NA 0.93 15.32 0.65 2.37e-40 Dupuytren's disease; CRC cis rs2239547 0.563 rs9839035 chr3:52909877 C/T cg10802521 chr3:52805072 NEK4 -0.47 -6.52 -0.34 2.64e-10 Schizophrenia; CRC cis rs7224737 1.000 rs9912088 chr17:40288278 T/C cg02450064 chr17:40260053 DHX58 -0.42 -6.11 -0.32 2.75e-9 Fibrinogen levels; CRC cis rs9303280 0.901 rs8067378 chr17:38051348 A/G cg20243544 chr17:37824526 PNMT 0.43 6.63 0.34 1.41e-10 Self-reported allergy; CRC cis rs798554 0.759 rs1182189 chr7:2869522 G/A cg14895029 chr7:2775587 GNA12 -0.42 -5.98 -0.31 5.74e-9 Height; CRC cis rs939574 0.512 rs908197 chr2:220144410 G/C cg00496455 chr2:220118770 TUBA4A;TUBA4B 0.57 6.51 0.34 2.77e-10 Platelet distribution width; CRC cis rs1862618 0.853 rs832583 chr5:56178217 A/C cg18230493 chr5:56204884 C5orf35 -0.75 -9.27 -0.45 2.61e-18 Initial pursuit acceleration; CRC cis rs1129187 0.755 rs9471986 chr6:42944127 A/G cg02359409 chr6:42947317 PEX6 -0.69 -11.52 -0.54 5.04e-26 Alzheimer's disease in APOE e4+ carriers; CRC trans rs9388451 0.903 rs9388446 chr6:126064920 T/A cg05039488 chr6:79577232 IRAK1BP1 -0.58 -8.86 -0.44 5.13e-17 Brugada syndrome; CRC cis rs4926298 1.000 rs931068 chr19:13158678 A/G cg11738485 chr19:12877000 HOOK2 -0.41 -5.68 -0.3 2.91e-8 Bipolar disorder; CRC cis rs995000 0.899 rs1305521 chr1:62949034 A/G cg19896129 chr1:63156450 NA -0.45 -6.89 -0.36 2.83e-11 Triglyceride levels; CRC cis rs10504229 1.000 rs117231141 chr8:58185465 A/G cg22535103 chr8:58192502 C8orf71 -0.82 -12.27 -0.56 9.63e-29 Developmental language disorder (linguistic errors); CRC cis rs514406 0.621 rs881198 chr1:53196440 C/T cg25767906 chr1:53392781 SCP2 0.42 6.62 0.34 1.48e-10 Monocyte count; CRC cis rs11190604 1.000 rs4919469 chr10:102298855 C/A cg07080220 chr10:102295463 HIF1AN 0.47 5.66 0.3 3.31e-8 Palmitoleic acid (16:1n-7) levels; CRC cis rs8180040 0.620 rs9858443 chr3:47086048 G/A cg27129171 chr3:47204927 SETD2 0.72 11.42 0.53 1.1e-25 Colorectal cancer; CRC cis rs365302 0.517 rs294876 chr6:159606982 A/C cg14500486 chr6:159655392 FNDC1 -0.43 -6.65 -0.34 1.21e-10 Coronary heart disease; CRC trans rs35110281 0.744 rs230646 chr21:44918788 A/G cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.4 6.28 0.33 1.05e-9 Mean corpuscular volume; CRC cis rs1816752 0.870 rs9318529 chr13:24998328 A/G cg02811702 chr13:24901961 NA 0.43 5.97 0.31 6.02e-9 Obesity-related traits; CRC cis rs908922 0.676 rs4845788 chr1:152519496 T/C cg09873164 chr1:152488093 CRCT1 0.41 6.79 0.35 5.18e-11 Hair morphology; CRC cis rs1707322 0.650 rs4553239 chr1:46150486 C/A cg03146154 chr1:46216737 IPP 0.68 9.78 0.47 5.23e-20 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs7615952 0.609 rs13088451 chr3:125553499 G/C cg05084668 chr3:125655381 ALG1L -0.46 -6.41 -0.33 5.14e-10 Blood pressure (smoking interaction); CRC cis rs4654899 0.897 rs6670897 chr1:21066376 T/C cg02927042 chr1:21476669 EIF4G3 -0.43 -6.82 -0.35 4.42e-11 Superior frontal gyrus grey matter volume; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg03044510 chr21:27107978 ATP5J;GABPA -0.43 -6.4 -0.33 5.21e-10 Myopia (pathological); CRC cis rs10504229 0.593 rs10504216 chr8:57981470 G/A cg08219700 chr8:58056026 NA 0.56 6.29 0.33 9.91e-10 Developmental language disorder (linguistic errors); CRC cis rs1707322 1.000 rs4298677 chr1:46306619 G/A cg06784218 chr1:46089804 CCDC17 0.51 8.94 0.44 2.87e-17 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs1046896 0.586 rs9897951 chr17:80810662 T/C cg19500275 chr17:80737654 TBCD 0.5 6.76 0.35 6.19e-11 Glycated hemoglobin levels; CRC cis rs8180040 0.764 rs11708451 chr3:47198826 G/A cg27129171 chr3:47204927 SETD2 0.68 11.12 0.52 1.36e-24 Colorectal cancer; CRC cis rs12451471 0.559 rs34746710 chr17:78079224 G/A cg08347473 chr17:78092826 GAA -0.37 -6.3 -0.33 9.48e-10 Plateletcrit;Mean corpuscular hemoglobin concentration; CRC cis rs8060686 0.858 rs10468274 chr16:67922342 C/T cg01951491 chr16:67709440 GFOD2 -0.45 -5.9 -0.31 9.09e-9 HDL cholesterol;Metabolic syndrome; CRC cis rs208520 0.690 rs7739253 chr6:66861052 A/G cg07460842 chr6:66804631 NA -1.06 -14.8 -0.63 2.51e-38 Exhaled nitric oxide output; CRC cis rs9858542 0.953 rs11719996 chr3:49525958 T/C cg07274523 chr3:49395745 GPX1 0.47 6.4 0.33 5.33e-10 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs7208859 0.623 rs28627615 chr17:29145817 G/C cg13385521 chr17:29058706 SUZ12P 0.74 8.44 0.42 9.97e-16 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs634534 0.562 rs661335 chr11:65754061 G/A cg02427764 chr11:65769310 BANF1;EIF1AD 0.4 5.77 0.3 1.84e-8 Sum eosinophil basophil counts;Eosinophil counts; CRC cis rs6500602 0.674 rs8051695 chr16:4536621 T/C cg08645402 chr16:4508243 NA 0.58 9.28 0.46 2.42e-18 Schizophrenia; CRC cis rs11628318 0.614 rs7143048 chr14:103119800 C/T cg12046867 chr14:103022105 NA 0.76 9.03 0.45 1.44e-17 Platelet count; CRC cis rs7666738 0.830 rs6840766 chr4:99016260 C/G cg17366294 chr4:99064904 C4orf37 0.44 7.35 0.38 1.55e-12 Colonoscopy-negative controls vs population controls; CRC cis rs6500602 0.701 rs4785969 chr16:4536934 A/T cg02873098 chr16:4524103 NMRAL1;HMOX2 0.39 5.64 0.3 3.63e-8 Schizophrenia; CRC cis rs2836974 0.623 rs34240248 chr21:40685239 A/G cg17971929 chr21:40555470 PSMG1 -0.67 -9.77 -0.47 5.87e-20 Cognitive function; CRC cis rs7677751 0.806 rs4864861 chr4:55097685 C/T cg00691999 chr4:55094011 PDGFRA 0.42 5.98 0.31 5.69e-9 Corneal astigmatism; CRC cis rs4523957 0.928 rs1122645 chr17:2170858 A/G cg16513277 chr17:2031491 SMG6 -0.54 -9.27 -0.45 2.58e-18 Autism spectrum disorder or schizophrenia;Schizophrenia; CRC cis rs7429990 0.965 rs4858887 chr3:48092017 G/T cg11946769 chr3:48343235 NME6 -0.5 -6.37 -0.33 6.43e-10 Educational attainment (years of education); CRC cis rs10911232 0.542 rs12128323 chr1:183050087 G/A ch.1.3577855R chr1:183094577 LAMC1 0.82 14.22 0.62 4.34e-36 Hypertriglyceridemia; CRC cis rs2070488 0.766 rs6808093 chr3:38498160 T/C cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.75 13.13 0.59 5.98e-32 Electrocardiographic conduction measures; CRC cis rs6460942 0.591 rs7804805 chr7:12332066 C/G cg06484146 chr7:12443880 VWDE -0.64 -6.83 -0.35 4.2e-11 Coronary artery disease; CRC cis rs6921919 0.789 rs6912584 chr6:28309590 T/C cg21251018 chr6:28226885 NKAPL 0.4 5.7 0.3 2.68e-8 Autism spectrum disorder or schizophrenia; CRC cis rs13191362 1.000 rs34773528 chr6:163088796 G/C cg23758597 chr6:163146217 PARK2 -0.66 -6.64 -0.34 1.29e-10 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs7633770 0.786 rs1520488 chr3:46677459 C/T cg11219411 chr3:46661640 NA 0.53 8.54 0.43 5.14e-16 Coronary artery disease; CRC cis rs798554 0.660 rs2644275 chr7:2854010 G/A cg19717773 chr7:2847554 GNA12 -0.48 -8.08 -0.41 1.25e-14 Height; CRC cis rs523522 0.962 rs3742052 chr12:120966921 A/G cg27279351 chr12:120934652 DYNLL1 0.78 11.48 0.53 7.05e-26 High light scatter reticulocyte count; CRC cis rs7615952 0.576 rs4646763 chr3:125822129 G/A cg18479299 chr3:125709523 NA -0.55 -6.59 -0.34 1.75e-10 Blood pressure (smoking interaction); CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg17166282 chr13:103249241 TPP2 0.44 6.29 0.33 1.04e-9 Anxiety disorder; CRC cis rs4253772 0.591 rs6007748 chr22:46657798 A/G cg09491104 chr22:46646882 C22orf40 -0.48 -7.43 -0.38 9.26e-13 LDL cholesterol;Cholesterol, total; CRC cis rs1448094 0.511 rs11610371 chr12:86163487 A/G cg18827107 chr12:86230957 RASSF9 -0.38 -5.74 -0.3 2.17e-8 Major depressive disorder; CRC cis rs2075371 0.933 rs1421481 chr7:133964380 A/C cg11752832 chr7:134001865 SLC35B4 0.43 6.65 0.34 1.26e-10 Mean platelet volume; CRC cis rs73206853 0.764 rs7311376 chr12:110605559 C/T cg12870014 chr12:110450643 ANKRD13A 0.82 10.57 0.5 1.09e-22 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC cis rs897984 0.646 rs9938088 chr16:30830004 G/A cg02466173 chr16:30829666 NA -0.8 -13.87 -0.61 9.07e-35 Dementia with Lewy bodies; CRC cis rs2013441 0.965 rs2386485 chr17:20095246 G/A cg13482628 chr17:19912719 NA -0.4 -6.07 -0.32 3.43e-9 Obesity-related traits; CRC cis rs13191362 0.808 rs13217502 chr6:163231414 C/T cg06582575 chr6:163149167 PACRG;PARK2 0.69 8.77 0.44 9.72e-17 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs7191439 0.789 rs4598894 chr16:88776141 G/A cg02389323 chr16:88786976 FAM38A 1.09 8.88 0.44 4.36e-17 Plateletcrit; CRC trans rs747782 0.527 rs75915859 chr11:48232931 C/T cg15704280 chr7:45808275 SEPT13 0.68 6.57 0.34 1.99e-10 Intraocular pressure; CRC cis rs9326248 0.798 rs10892079 chr11:117016824 T/G cg26566898 chr11:117069891 TAGLN 0.42 8.52 0.43 5.95e-16 Blood protein levels; CRC cis rs9875589 0.509 rs1586514 chr3:14050157 G/A cg14375111 chr3:14165186 TMEM43;CHCHD4 0.41 6.17 0.32 2.01e-9 Ovarian reserve; CRC cis rs597539 0.518 rs35093305 chr11:68730729 A/G cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.8 13.03 0.58 1.38e-31 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs4862750 0.872 rs6830828 chr4:187897472 T/G cg06074448 chr4:187884817 NA -0.58 -10.81 -0.51 1.71e-23 Lobe attachment (rater-scored or self-reported); CRC cis rs853679 0.517 rs9348793 chr6:28084189 G/A cg02683197 chr6:28174875 NA 0.85 10.27 0.49 1.16e-21 Depression; CRC cis rs990171 0.913 rs6718157 chr2:103079814 A/T cg03938978 chr2:103052716 IL18RAP 0.46 5.88 0.31 1e-8 Lymphocyte counts; CRC cis rs977987 0.806 rs1549306 chr16:75415341 A/G cg03315344 chr16:75512273 CHST6 0.52 8.65 0.43 2.27e-16 Dupuytren's disease; CRC cis rs9467711 0.606 rs9379856 chr6:26366836 A/C cg16898833 chr6:26189333 HIST1H4D 0.76 6.58 0.34 1.88e-10 Autism spectrum disorder or schizophrenia; CRC cis rs477895 0.713 rs12575642 chr11:63979643 G/T cg23719950 chr11:63933701 MACROD1 -0.61 -7.81 -0.4 7.95e-14 Mean platelet volume; CRC cis rs35883536 1.000 rs12410168 chr1:101115321 G/A cg14515779 chr1:101123966 NA -0.42 -8.2 -0.41 5.63e-15 Monocyte count; CRC cis rs1008375 1.000 rs10939746 chr4:17684951 A/G cg16339924 chr4:17578868 LAP3 -0.52 -6.9 -0.36 2.71e-11 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs73195822 0.614 rs73194056 chr12:111216325 A/G cg12870014 chr12:110450643 ANKRD13A 0.67 7.46 0.38 8e-13 Itch intensity from mosquito bite; CRC cis rs60843830 1.000 rs7595075 chr2:264019 C/A cg25945732 chr2:264204 ACP1;SH3YL1 0.72 11.77 0.54 6.32e-27 Spherical equivalent (joint analysis main effects and education interaction); CRC cis rs6701037 0.625 rs34270511 chr1:175128543 C/T cg14847009 chr1:175162515 KIAA0040 -0.27 -5.85 -0.31 1.21e-8 Alcohol dependence; CRC cis rs2710642 0.815 rs6545971 chr2:63074986 A/T cg17519650 chr2:63277830 OTX1 0.44 6.31 0.33 8.95e-10 LDL cholesterol levels;LDL cholesterol; CRC cis rs2153535 0.580 rs4960423 chr6:8477210 C/T cg21535247 chr6:8435926 SLC35B3 0.5 7.53 0.38 4.89e-13 Motion sickness; CRC cis rs7274811 0.625 rs211041 chr20:31932068 A/G cg03904042 chr20:32255491 NECAB3;C20orf134 0.4 5.97 0.31 6.18e-9 Height; CRC cis rs4253772 0.513 rs9615345 chr22:46713631 C/T cg03482458 chr22:46692211 CN5H6.4;GTSE1 0.57 7.46 0.38 7.92e-13 LDL cholesterol;Cholesterol, total; CRC cis rs1018836 0.923 rs7007102 chr8:91629730 T/A cg16814680 chr8:91681699 NA -0.75 -11.86 -0.55 3e-27 Ejection fraction in Tripanosoma cruzi seropositivity; CRC cis rs853679 0.517 rs67878650 chr6:28142587 G/C cg02683197 chr6:28174875 NA 0.88 10.83 0.51 1.42e-23 Depression; CRC cis rs1691799 0.899 rs1168303 chr12:66738586 A/G cg16791601 chr12:66731901 HELB -0.66 -10.92 -0.52 6.61e-24 White blood cell count (basophil); CRC cis rs2841277 0.708 rs10083490 chr14:105402418 A/G cg15352829 chr14:105391018 PLD4 0.49 11.09 0.52 1.75e-24 Rheumatoid arthritis; CRC cis rs1178968 0.901 rs7795782 chr7:72766817 T/G cg25889504 chr7:72793014 NA 0.53 6.03 0.32 4.48e-9 Triglyceride levels; CRC cis rs11792861 0.962 rs11789624 chr9:111796231 T/C cg05043794 chr9:111880884 C9orf5 -0.34 -6.33 -0.33 8.15e-10 Menarche (age at onset); CRC cis rs10992471 0.651 rs2296669 chr9:95373790 A/G cg14631576 chr9:95140430 CENPP 0.39 6.91 0.36 2.59e-11 Visceral adipose tissue/subcutaneous adipose tissue ratio; CRC cis rs6951245 1.000 rs1881123 chr7:1084706 C/T cg22907277 chr7:1156413 C7orf50 0.71 7.38 0.38 1.32e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs891088 0.677 rs11670960 chr19:7185504 C/T cg00428638 chr19:7224713 INSR -0.59 -6.17 -0.32 1.99e-9 Hip circumference adjusted for BMI;Height; CRC cis rs798554 0.836 rs798502 chr7:2789880 G/T cg17321639 chr7:2759063 NA 0.46 6.2 0.32 1.69e-9 Height; CRC cis rs1580019 0.713 rs2122632 chr7:32524686 A/G cg14728415 chr7:32535168 LSM5;AVL9 -0.46 -6.26 -0.33 1.17e-9 Cognitive ability; CRC cis rs4481887 0.636 rs6672981 chr1:248407200 C/T cg00666640 chr1:248458726 OR2T12 0.47 7.63 0.39 2.6e-13 Common traits (Other); CRC cis rs7626444 0.625 rs9826214 chr3:196478213 C/T cg12930392 chr3:196481615 PAK2 0.38 6.86 0.35 3.49e-11 Monocyte count; CRC cis rs2976388 0.609 rs2585144 chr8:143800269 A/T cg15511327 chr8:143859410 LYNX1 0.39 6.85 0.35 3.62e-11 Urinary tract infection frequency; CRC cis rs11031096 0.502 rs4910598 chr11:4101368 C/T cg18678763 chr11:4115507 RRM1 -0.54 -8.5 -0.42 6.85e-16 Mean corpuscular volume;Mean corpuscular hemoglobin; CRC cis rs6840360 0.582 rs4473638 chr4:152322146 C/T cg09659197 chr4:152720779 NA 0.33 6.29 0.33 1.04e-9 Intelligence (multi-trait analysis); CRC cis rs2032447 0.839 rs9356995 chr6:25996673 G/A cg03264133 chr6:25882463 NA -0.46 -6.4 -0.33 5.31e-10 Intelligence (multi-trait analysis); CRC cis rs73195822 0.614 rs11065717 chr12:111208823 A/C cg12870014 chr12:110450643 ANKRD13A 0.71 8.13 0.41 8.65e-15 Itch intensity from mosquito bite; CRC cis rs11229555 0.598 rs12276438 chr11:58185419 G/A cg15696309 chr11:58395628 NA -0.81 -10.31 -0.49 8.83e-22 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; CRC cis rs4642101 0.618 rs11128614 chr3:12819212 A/G cg24848339 chr3:12840334 CAND2 0.33 6.14 0.32 2.42e-9 QRS complex (12-leadsum); CRC cis rs477692 0.647 rs524804 chr10:131430686 G/A cg05714579 chr10:131428358 MGMT -0.71 -10.87 -0.51 1.01e-23 Response to temozolomide; CRC cis rs6540559 0.673 rs58637469 chr1:209971480 T/A cg21951975 chr1:209979733 IRF6 0.49 6.6 0.34 1.66e-10 Cleft lip with or without cleft palate; CRC cis rs1867631 0.585 rs12062570 chr1:67086285 T/C cg02459107 chr1:67143332 SGIP1 0.35 6.32 0.33 8.4e-10 Menopause (age at onset); CRC cis rs6912958 0.559 rs242279 chr6:88048191 A/G cg12350822 chr6:88032061 C6orf162;GJB7 0.46 9.42 0.46 8.19e-19 Monocyte percentage of white cells; CRC cis rs7726839 0.574 rs11739866 chr5:636299 C/T cg17948913 chr5:572064 NA 0.51 5.89 0.31 9.53e-9 Obesity-related traits; CRC cis rs4594175 0.926 rs4414399 chr14:51596929 G/T cg23942311 chr14:51606299 NA 0.67 10.71 0.51 3.62e-23 Cancer; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg10656664 chr5:853447 NA -0.4 -6.57 -0.34 1.93e-10 Liver disease severity in Alagille syndrome; CRC trans rs459571 0.959 rs465535 chr9:136910905 C/T cg15028160 chr19:49622717 PPFIA3;C19orf73 -0.56 -7.22 -0.37 3.65e-12 Platelet distribution width; CRC trans rs11098499 0.863 rs1480939 chr4:120456927 T/C cg25214090 chr10:38739885 LOC399744 0.64 9.99 0.48 1.03e-20 Corneal astigmatism; CRC cis rs8103278 0.507 rs4802275 chr19:46260375 C/T cg14061069 chr19:46274453 DMPK 0.69 12.71 0.57 2.2e-30 Coronary artery disease; CRC cis rs250677 0.687 rs36048 chr5:148441713 G/C cg18129178 chr5:148520854 ABLIM3 -0.36 -5.7 -0.3 2.62e-8 Breast cancer; CRC trans rs9291683 0.588 rs11732054 chr4:9999877 C/T cg26043149 chr18:55253948 FECH 0.51 7.95 0.4 3.02e-14 Bone mineral density; CRC cis rs11112613 0.775 rs10778413 chr12:105962118 G/A cg03607813 chr12:105948248 NA 0.8 10.45 0.5 2.88e-22 Corrected insulin response;Corrected insulin response adjusted for insulin sensitivity index; CRC cis rs1046896 0.553 rs2292965 chr17:80900645 G/A cg03160526 chr17:80928410 B3GNTL1 0.63 8.74 0.43 1.25e-16 Glycated hemoglobin levels; CRC cis rs7727544 0.836 rs10463892 chr5:131598705 T/C cg02033258 chr5:131593261 PDLIM4 0.35 6.89 0.36 2.78e-11 Blood metabolite levels; CRC cis rs941408 0.515 rs2110118 chr19:2775144 T/C cg17333051 chr19:2783644 SGTA 0.45 6.89 0.35 2.92e-11 Total cholesterol levels; CRC cis rs9534288 0.797 rs7338189 chr13:46571035 T/C cg15192986 chr13:46630673 CPB2 -0.67 -9.85 -0.48 3.16e-20 Blood protein levels; CRC cis rs10504229 0.683 rs6999131 chr8:58127052 C/A cg02290350 chr8:58132656 NA -0.59 -7.11 -0.36 7.43e-12 Developmental language disorder (linguistic errors); CRC cis rs9649213 0.593 rs1859482 chr7:97983774 C/T cg21770322 chr7:97807741 LMTK2 0.53 8.62 0.43 2.78e-16 Prostate cancer (SNP x SNP interaction); CRC cis rs9788333 0.962 rs12584792 chr13:21887208 C/T cg25811766 chr13:21894605 NA 0.61 9.06 0.45 1.18e-17 Thiazide-induced adverse metabolic effects in hypertensive patients; CRC cis rs17601876 0.814 rs28520437 chr15:51553277 C/T cg19946085 chr15:51559439 CYP19A1 -0.33 -6.73 -0.35 7.76e-11 Estrone/androstenedione ratio in resected early stage-receptor positive breast cancer; CRC cis rs7666738 0.830 rs2865977 chr4:99017916 C/T cg05340658 chr4:99064831 C4orf37 0.61 9.51 0.46 4.3e-19 Colonoscopy-negative controls vs population controls; CRC cis rs6968419 0.755 rs3807983 chr7:115898991 T/C cg02561103 chr7:115862891 TES -0.44 -6.61 -0.34 1.58e-10 Intraocular pressure; CRC cis rs394563 0.726 rs6906384 chr6:149664540 G/A cg11245181 chr6:149772854 ZC3H12D 0.53 9.38 0.46 1.09e-18 Dupuytren's disease; CRC cis rs919433 0.926 rs787997 chr2:198216271 A/G cg10820045 chr2:198174542 NA 0.46 8.21 0.41 5.04e-15 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC cis rs561341 0.941 rs8066558 chr17:30272879 G/T cg12193833 chr17:30244370 NA -0.63 -8.19 -0.41 5.67e-15 Hip circumference adjusted for BMI; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg16271524 chr11:66139231 SLC29A2 0.4 6.03 0.32 4.43e-9 Intelligence (multi-trait analysis); CRC cis rs17767392 0.958 rs8014349 chr14:72046496 C/A cg13720639 chr14:72061746 SIPA1L1 0.55 6.82 0.35 4.27e-11 Mitral valve prolapse; CRC cis rs2243480 1.000 rs7778911 chr7:65694506 T/C cg18252515 chr7:66147081 NA 1.26 14.46 0.62 5.09e-37 Diabetic kidney disease; CRC cis rs951366 0.528 rs1172198 chr1:205662718 C/T cg14893161 chr1:205819251 PM20D1 0.74 10.72 0.51 3.31e-23 Menarche (age at onset); CRC cis rs2011503 1.000 rs2965194 chr19:19460702 C/T cg11584989 chr19:19387371 SF4 -0.53 -6.2 -0.32 1.74e-9 Bipolar disorder; CRC cis rs4423214 0.840 rs1790339 chr11:71182761 C/A cg05163923 chr11:71159392 DHCR7 -0.63 -7.61 -0.39 2.92e-13 Vitamin D levels; CRC cis rs9409565 0.586 rs9409764 chr9:97219391 C/T cg04523069 chr9:97136363 HIATL1 0.43 6.06 0.32 3.75e-9 Colorectal cancer (alcohol consumption interaction); CRC cis rs736408 0.716 rs2239549 chr3:52823126 C/T cg05573699 chr3:52720067 GNL3;PBRM1 -0.47 -6.48 -0.34 3.27e-10 Bipolar disorder; CRC cis rs6460942 0.841 rs17443848 chr7:12443688 A/G cg10578991 chr7:12443926 VWDE -0.44 -5.74 -0.3 2.1e-8 Coronary artery disease; CRC trans rs7937682 0.889 rs11213971 chr11:111529829 A/G cg18187862 chr3:45730750 SACM1L 0.49 7.05 0.36 1.07e-11 Primary sclerosing cholangitis; CRC cis rs208520 0.690 rs1885100 chr6:66871047 C/G cg07460842 chr6:66804631 NA -1.07 -14.89 -0.63 1.12e-38 Exhaled nitric oxide output; CRC cis rs6963495 0.818 rs6955796 chr7:105170321 T/G cg13798780 chr7:105162888 PUS7 0.68 8.04 0.41 1.59e-14 Bipolar disorder (body mass index interaction); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg17796897 chr19:18403201 NA 0.45 6.77 0.35 5.89e-11 Intelligence (multi-trait analysis); CRC cis rs2033711 0.902 rs4801589 chr19:58953398 C/G cg13877915 chr19:58951672 ZNF132 0.48 7.75 0.39 1.17e-13 Uric acid clearance; CRC cis rs7662987 0.517 rs1311618 chr4:100012612 A/G cg13256891 chr4:100009986 ADH5 0.63 8.4 0.42 1.39e-15 Smoking initiation; CRC cis rs7107174 1.000 rs1385600 chr11:77936166 C/T cg02023728 chr11:77925099 USP35 -0.52 -8.83 -0.44 6.26e-17 Testicular germ cell tumor; CRC cis rs1348850 0.519 rs10201883 chr2:178471407 T/C cg22681709 chr2:178499509 PDE11A -0.42 -5.67 -0.3 3.11e-8 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs7940866 0.903 rs7130842 chr11:130836269 A/G cg12179176 chr11:130786555 SNX19 0.56 8.36 0.42 1.77e-15 Schizophrenia; CRC cis rs10504229 1.000 rs72650900 chr8:58185675 T/A cg24829409 chr8:58192753 C8orf71 -0.68 -11.34 -0.53 2.27e-25 Developmental language disorder (linguistic errors); CRC cis rs59918340 0.764 rs4961258 chr8:142232878 A/G cg17298326 chr8:142245477 NA 0.4 6.15 0.32 2.29e-9 Immature fraction of reticulocytes; CRC trans rs7618501 1.000 rs7618519 chr3:49772708 A/T cg21582582 chr3:182698605 DCUN1D1 -0.56 -8.34 -0.42 2.08e-15 Intelligence (multi-trait analysis); CRC cis rs11148252 0.904 rs9536079 chr13:53030565 G/A cg00495681 chr13:53174319 NA 0.66 10.38 0.5 5.1e-22 Lewy body disease; CRC cis rs501120 0.925 rs1657345 chr10:44779078 A/G cg09554077 chr10:44749378 NA 0.81 10.36 0.5 5.84e-22 Coronary artery disease;Coronary heart disease; CRC cis rs9355610 0.609 rs62436424 chr6:167374258 A/G cg23791538 chr6:167370224 RNASET2 0.53 7.53 0.38 4.81e-13 Graves' disease; CRC cis rs11711311 1.000 rs12695295 chr3:113474866 A/G cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.51 -7.0 -0.36 1.49e-11 IgG glycosylation; CRC cis rs7811142 0.779 rs111312383 chr7:99905325 C/T cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.66 8.42 0.42 1.15e-15 Platelet count; CRC trans rs10842750 1.000 rs10842750 chr12:26690565 G/T cg05127153 chr1:6452942 ACOT7 0.51 6.15 0.32 2.28e-9 Kashin-Beck disease; CRC cis rs7772486 0.754 rs6570718 chr6:146088443 T/G cg23711669 chr6:146136114 FBXO30 -0.78 -13.21 -0.59 3e-32 Lobe attachment (rater-scored or self-reported); CRC cis rs936229 0.656 rs2290572 chr15:75130573 A/G cg17294928 chr15:75287854 SCAMP5 0.37 5.66 0.3 3.29e-8 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); CRC cis rs7927771 1.000 rs11605774 chr11:47832793 G/A cg18512352 chr11:47633146 NA -0.49 -9.49 -0.46 5.02e-19 Subjective well-being; CRC cis rs1862618 0.853 rs1423620 chr5:56100996 G/T cg20203395 chr5:56204925 C5orf35 -0.57 -6.54 -0.34 2.34e-10 Initial pursuit acceleration; CRC cis rs10504229 0.683 rs79284841 chr8:58107611 T/A cg20607798 chr8:58055168 NA 0.58 6.56 0.34 2.06e-10 Developmental language disorder (linguistic errors); CRC cis rs4363385 0.574 rs61813182 chr1:152943868 T/A cg25856811 chr1:152973957 SPRR3 -0.25 -6.6 -0.34 1.64e-10 Inflammatory skin disease; CRC cis rs7692995 1.000 rs6449345 chr4:17934394 A/T cg08925142 chr4:18023851 LCORL -0.52 -5.85 -0.31 1.21e-8 Height; CRC cis rs1733410 0.504 rs11181874 chr12:37912890 C/A cg13010199 chr12:38710504 ALG10B -0.49 -7.17 -0.37 4.87e-12 Morning vs. evening chronotype; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg06563602 chr4:130014800 C4orf33;SCLT1 0.43 6.18 0.32 1.88e-9 Intelligence (multi-trait analysis); CRC cis rs9660992 0.573 rs1318187 chr1:205206172 T/A cg21643547 chr1:205240462 TMCC2 -0.38 -6.13 -0.32 2.58e-9 Mean corpuscular volume;Mean platelet volume; CRC cis rs1552244 0.832 rs115415687 chr3:10195704 C/T cg16606324 chr3:10149918 C3orf24 0.62 7.1 0.36 7.6e-12 Alzheimer's disease; CRC cis rs11098499 0.821 rs28665282 chr4:120384186 C/T cg09307838 chr4:120376055 NA 0.71 10.92 0.52 6.75e-24 Corneal astigmatism; CRC cis rs2070488 0.965 rs1065800 chr3:38566480 C/T cg01465620 chr3:38496096 LOC100128640;ACVR2B -0.91 -16.6 -0.68 2.12e-45 Electrocardiographic conduction measures; CRC cis rs7666738 0.710 rs7674407 chr4:98838522 A/G cg05340658 chr4:99064831 C4orf37 0.55 7.98 0.4 2.43e-14 Colonoscopy-negative controls vs population controls; CRC cis rs7811142 1.000 rs7794485 chr7:100068936 T/C cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.17 16.02 0.66 4.12e-43 Platelet count; CRC cis rs12900413 0.603 rs11629982 chr15:90300272 G/A cg24249390 chr15:90295951 MESP1 -0.58 -8.91 -0.44 3.45e-17 Coronary artery aneurysm in Kawasaki disease; CRC cis rs2859741 0.565 rs12031540 chr1:37513757 C/T cg09363841 chr1:37513479 NA -0.46 -7.69 -0.39 1.78e-13 Forced expiratory volume in 1 second (environmental tobacco smoke interaction); CRC cis rs6546324 0.625 rs2902023 chr2:67830279 A/G cg15745817 chr2:67799979 NA -0.55 -9.07 -0.45 1.1e-17 Endometriosis; CRC cis rs10504229 1.000 rs116995796 chr8:58181960 G/A cg02290350 chr8:58132656 NA -0.42 -5.95 -0.31 6.68e-9 Developmental language disorder (linguistic errors); CRC cis rs7613875 0.580 rs12634780 chr3:50043341 A/T cg05623727 chr3:50126028 RBM5 -0.56 -9.75 -0.47 6.66e-20 Body mass index; CRC cis rs875971 0.862 rs9791713 chr7:66105198 C/A cg18876405 chr7:65276391 NA -0.53 -8.5 -0.42 6.79e-16 Aortic root size; CRC trans rs60843830 1.000 rs59937473 chr2:271797 G/A cg11347411 chr7:150020925 ACTR3C;LRRC61 0.56 8.73 0.43 1.29e-16 Spherical equivalent (joint analysis main effects and education interaction); CRC cis rs1707322 1.000 rs6682683 chr1:46342337 A/G cg03146154 chr1:46216737 IPP 0.5 6.97 0.36 1.7e-11 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs2635047 0.811 rs12957869 chr18:44786869 C/G cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.36 5.66 0.3 3.28e-8 Educational attainment; CRC trans rs9329221 0.905 rs4610752 chr8:10248962 A/G cg16141378 chr3:129829833 LOC729375 0.45 6.85 0.35 3.54e-11 Neuroticism; CRC trans rs6703335 0.870 rs10803142 chr1:243598234 A/G cg08307039 chr5:64920116 TRIM23;C5orf44 0.44 6.08 0.32 3.38e-9 Schizophrenia;Schizophrenia, schizoaffective disorder or bipolar disorder; CRC cis rs6580110 0.793 rs9324792 chr5:154078564 A/G cg11923914 chr5:154071666 NA -0.49 -7.69 -0.39 1.71e-13 Facial morphology (factor 9, facial height related to vertical position of nasion); CRC cis rs1552244 0.816 rs56271597 chr3:10042790 C/T cg08888203 chr3:10149979 C3orf24 0.64 8.64 0.43 2.5e-16 Alzheimer's disease; CRC cis rs7666738 0.830 rs72882693 chr4:98960804 T/A cg17366294 chr4:99064904 C4orf37 0.43 7.36 0.38 1.49e-12 Colonoscopy-negative controls vs population controls; CRC cis rs2882667 0.690 rs288018 chr5:138192416 G/A cg09476006 chr5:138032270 NA -0.54 -8.92 -0.44 3.39e-17 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs34172651 0.876 rs2547033 chr16:24743657 C/T cg06028605 chr16:24865363 SLC5A11 0.4 7.77 0.39 9.86e-14 Intelligence (multi-trait analysis); CRC trans rs61332075 0.540 rs55986470 chr2:239363773 A/G cg01134436 chr17:81009848 B3GNTL1 0.56 6.11 0.32 2.87e-9 Lung function (FEV1/FVC); CRC cis rs909002 1.000 rs1474182 chr1:32136398 C/T cg13919466 chr1:32135498 COL16A1 -0.39 -7.35 -0.38 1.62e-12 Intelligence (multi-trait analysis); CRC cis rs1580019 0.534 rs13237495 chr7:32560687 A/G cg07520158 chr7:32535189 LSM5;AVL9 0.52 7.69 0.39 1.73e-13 Cognitive ability; CRC cis rs6502050 0.835 rs9911379 chr17:80114529 A/G cg25804541 chr17:80189381 SLC16A3 -0.29 -5.64 -0.3 3.67e-8 Life satisfaction; CRC cis rs12431939 1.000 rs11850391 chr14:51639759 A/G cg23942311 chr14:51606299 NA -0.49 -5.62 -0.3 4.18e-8 Cancer; CRC cis rs11098499 0.722 rs7673476 chr4:120248683 C/T cg24375607 chr4:120327624 NA 0.43 6.82 0.35 4.49e-11 Corneal astigmatism; CRC cis rs12476592 0.543 rs4671510 chr2:63742880 A/G cg10828910 chr2:63850056 LOC388955 0.49 6.07 0.32 3.6e-9 Childhood ear infection; CRC cis rs9611565 0.625 rs2076199 chr22:41903743 G/T cg03806693 chr22:41940476 POLR3H -0.78 -10.99 -0.52 3.95e-24 Vitiligo; CRC cis rs9527 0.590 rs3781282 chr10:104852419 C/T cg04362960 chr10:104952993 NT5C2 -0.6 -8.37 -0.42 1.68e-15 Arsenic metabolism; CRC cis rs6952808 0.792 rs11771973 chr7:1950440 C/G cg22963979 chr7:1858916 MAD1L1 -0.52 -7.65 -0.39 2.3e-13 Bipolar disorder and schizophrenia; CRC cis rs7208859 0.623 rs216423 chr17:28942109 G/C cg14008862 chr17:28927542 LRRC37B2 0.5 5.92 0.31 8.28e-9 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs11711311 0.955 rs9823423 chr3:113419741 A/G cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.48 -6.33 -0.33 7.86e-10 IgG glycosylation; CRC cis rs8014671 0.597 rs8021180 chr14:70783943 A/G cg21512124 chr14:70655805 SLC8A3 -0.31 -6.01 -0.31 4.95e-9 Prostate cancer; CRC trans rs2727020 0.729 rs4315497 chr11:49214499 G/A cg21153622 chr11:89784906 NA 0.43 6.9 0.36 2.64e-11 Coronary artery disease; CRC cis rs10782582 0.546 rs79652169 chr1:76233882 G/A cg03433033 chr1:76189801 ACADM -0.44 -6.38 -0.33 6.18e-10 Daytime sleep phenotypes; CRC cis rs7618915 0.501 rs2336149 chr3:52692124 G/A cg18099408 chr3:52552593 STAB1 -0.47 -8.01 -0.4 2.01e-14 Bipolar disorder; CRC cis rs1801251 1.000 rs6437074 chr2:233712296 C/T cg25237894 chr2:233734115 C2orf82 -0.49 -7.69 -0.39 1.68e-13 Coronary artery disease; CRC cis rs9443645 0.869 rs7762022 chr6:79502859 C/A cg05283184 chr6:79620031 NA -0.57 -9.16 -0.45 5.54e-18 Intelligence (multi-trait analysis); CRC cis rs4713118 0.513 rs149958 chr6:28013617 A/C cg03623178 chr6:28175578 NA 0.77 11.36 0.53 1.93e-25 Parkinson's disease; CRC cis rs637571 0.522 rs679581 chr11:65746653 A/G cg17985854 chr11:65770987 BANF1;EIF1AD 0.53 8.79 0.44 8.66e-17 Eosinophil percentage of white cells; CRC cis rs1555322 0.530 rs6060341 chr20:33863633 C/T cg08210727 chr20:33865349 NA -0.49 -6.32 -0.33 8.63e-10 Attention deficit hyperactivity disorder; CRC cis rs61160187 0.556 rs55738840 chr5:60273414 G/C cg16298547 chr5:60138761 ELOVL7 -0.27 -5.73 -0.3 2.26e-8 Educational attainment (years of education);Educational attainment (college completion); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg02335971 chr8:121457381 MTBP;MRPL13 0.4 6.3 0.33 9.68e-10 Liver disease severity in Alagille syndrome; CRC cis rs35306767 0.953 rs34405399 chr10:981015 G/A cg26597838 chr10:835615 NA 0.8 9.97 0.48 1.2e-20 Eosinophil percentage of granulocytes; CRC cis rs1448094 0.785 rs6539941 chr12:86452813 G/T cg18827107 chr12:86230957 RASSF9 0.36 5.72 0.3 2.36e-8 Major depressive disorder; CRC cis rs12824058 0.831 rs12314111 chr12:130813663 G/T cg26677194 chr12:130822605 PIWIL1 0.44 7.11 0.36 7.26e-12 Menopause (age at onset); CRC cis rs2153535 0.580 rs1360054 chr6:8520377 C/A cg21535247 chr6:8435926 SLC35B3 0.47 7.33 0.37 1.83e-12 Motion sickness; CRC cis rs11098499 0.954 rs11940028 chr4:120411907 T/C cg09307838 chr4:120376055 NA 0.7 10.94 0.52 5.58e-24 Corneal astigmatism; CRC cis rs2836974 0.897 rs8132568 chr21:40527916 C/T cg17971929 chr21:40555470 PSMG1 0.83 12.88 0.58 5.05e-31 Cognitive function; CRC cis rs2243480 1.000 rs35283677 chr7:65359233 C/T cg25985355 chr7:65971099 NA -0.5 -5.69 -0.3 2.86e-8 Diabetic kidney disease; CRC cis rs17253792 0.822 rs76192881 chr14:56034654 C/T cg01858014 chr14:56050164 KTN1 -0.87 -6.89 -0.36 2.87e-11 Putamen volume; CRC cis rs11608355 0.557 rs759971 chr12:109826046 A/T cg19025524 chr12:109796872 NA -0.57 -9.19 -0.45 4.64e-18 Neuroticism; CRC cis rs1044826 0.642 rs7652860 chr3:139205818 T/A cg15131784 chr3:139108705 COPB2 0.39 5.63 0.3 3.89e-8 Obesity-related traits; CRC cis rs3768617 0.510 rs10737245 chr1:183100884 G/A ch.1.3577855R chr1:183094577 LAMC1 0.89 15.86 0.66 1.84e-42 Fuchs's corneal dystrophy; CRC cis rs727505 1.000 rs10233596 chr7:124556659 A/G cg23710748 chr7:124431027 NA -0.83 -14.62 -0.63 1.2e-37 Lewy body disease; CRC cis rs9611565 0.659 rs73178626 chr22:41928371 T/G cg17554472 chr22:41940697 POLR3H -0.55 -5.84 -0.31 1.23e-8 Vitiligo; CRC cis rs9381040 0.610 rs742495 chr6:41018233 A/G cg04346459 chr6:41068666 NFYA;LOC221442 -0.41 -6.12 -0.32 2.64e-9 Alzheimer's disease (late onset); CRC cis rs6496044 0.568 rs12899946 chr15:86066082 C/T cg17133734 chr15:86042851 AKAP13 0.4 6.51 0.34 2.8e-10 Interstitial lung disease; CRC cis rs7927771 0.524 rs7933896 chr11:47882782 C/T cg20307385 chr11:47447363 PSMC3 0.45 6.64 0.34 1.33e-10 Subjective well-being; CRC cis rs2108225 0.714 rs929393 chr7:107437048 C/T cg18560240 chr7:107437656 SLC26A3 -0.61 -9.52 -0.46 3.86e-19 Ulcerative colitis; CRC trans rs2324229 0.797 rs1180237 chr6:83943928 A/C cg04803921 chr20:30102855 HM13 -0.41 -5.96 -0.31 6.35e-9 Platelet-derived growth factor BB levels; CRC cis rs4664293 0.934 rs7604482 chr2:160513826 T/C cg08347373 chr2:160653686 CD302 -0.37 -6.15 -0.32 2.21e-9 Monocyte percentage of white cells; CRC cis rs4867766 0.585 rs10043212 chr5:173949740 C/T cg20434911 chr5:173954559 NA 0.61 6.83 0.35 4.03e-11 Stroke; CRC cis rs11123170 0.543 rs4849178 chr2:113982608 C/T cg21550016 chr2:113992930 PAX8;LOC440839;LOC654433 0.53 6.17 0.32 2.01e-9 Renal function-related traits (BUN); CRC cis rs2859741 0.546 rs10489413 chr1:37513906 C/T cg09363841 chr1:37513479 NA -0.48 -7.87 -0.4 5.15e-14 Forced expiratory volume in 1 second (environmental tobacco smoke interaction); CRC trans rs6011368 0.678 rs6062359 chr20:62900380 G/T cg13869341 chr1:15865 WASH5P -0.42 -6.48 -0.34 3.31e-10 Clozapine-induced cytotoxicity; CRC cis rs6860806 0.531 rs272887 chr5:131665713 A/G cg22638593 chr5:131593259 PDLIM4 0.38 6.21 0.32 1.59e-9 Breast cancer; CRC cis rs7568458 0.591 rs55971080 chr2:85812746 T/C cg02493740 chr2:85810744 VAMP5 -0.38 -6.14 -0.32 2.42e-9 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); CRC cis rs34638657 0.827 rs3829548 chr16:82206238 C/G cg07918374 chr16:82182319 MPHOSPH6 -0.68 -8.56 -0.43 4.4e-16 Lung adenocarcinoma; CRC cis rs9811920 0.599 rs1688758 chr3:99539890 A/T cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G -0.45 -5.95 -0.31 6.81e-9 Axial length; CRC cis rs6088580 0.634 rs6059779 chr20:32950325 C/T cg08999081 chr20:33150536 PIGU -0.62 -11.4 -0.53 1.39e-25 Glomerular filtration rate (creatinine); CRC cis rs4819052 0.851 rs4819041 chr21:46659955 C/T cg02159808 chr21:46707872 POFUT2;LOC642852 0.44 5.94 0.31 7.16e-9 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs10504229 0.953 rs66815941 chr8:58187306 C/T cg22535103 chr8:58192502 C8orf71 -0.82 -12.27 -0.56 9.63e-29 Developmental language disorder (linguistic errors); CRC cis rs7568498 0.517 rs197261 chr2:161904823 A/G cg08807892 chr2:162101083 NA -0.45 -6.05 -0.32 4.03e-9 Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 3 peripheral neuropathy); CRC cis rs798554 0.660 rs2644296 chr7:2859061 A/T cg13628971 chr7:2884303 GNA12 0.39 6.01 0.31 5e-9 Height; CRC cis rs6840360 0.571 rs62329101 chr4:152512239 G/T cg09659197 chr4:152720779 NA 0.31 5.67 0.3 3.05e-8 Intelligence (multi-trait analysis); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg16758041 chr9:32573371 NDUFB6 0.42 6.15 0.32 2.19e-9 Liver disease severity in Alagille syndrome; CRC cis rs1320333 0.772 rs111825088 chr2:695785 T/G cg20966539 chr2:681320 NA 0.62 5.88 0.31 1.01e-8 Obesity-related traits; CRC cis rs1707322 1.000 rs12403666 chr1:46431621 G/A cg03146154 chr1:46216737 IPP 0.51 7.08 0.36 8.64e-12 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs1075232 0.649 rs7170850 chr15:32123445 A/C cg08481732 chr15:32323009 CHRNA7 0.65 5.67 0.3 3.13e-8 Survival in colorectal cancer (non-distant metastatic); CRC cis rs12586317 0.547 rs114371385 chr14:35503724 G/A cg16230307 chr14:35515116 FAM177A1 0.91 10.73 0.51 3.18e-23 Psoriasis; CRC cis rs9462027 0.651 rs9469870 chr6:34744349 T/C cg07306190 chr6:34760872 UHRF1BP1 -0.35 -6.23 -0.33 1.4e-9 Systemic lupus erythematosus; CRC cis rs16852403 0.548 rs7547504 chr1:178201312 G/C cg00404053 chr1:178313656 RASAL2 0.5 6.55 0.34 2.21e-10 Childhood ear infection; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg24028381 chr8:145133668 EXOSC4 0.4 6.52 0.34 2.7e-10 Liver disease severity in Alagille syndrome; CRC cis rs13315871 1.000 rs12330157 chr3:58364562 C/T cg20936604 chr3:58311152 NA -0.75 -6.89 -0.35 2.89e-11 Cholesterol, total; CRC cis rs9910055 0.529 rs850851 chr17:42177674 C/T cg13607699 chr17:42295918 UBTF -0.48 -6.3 -0.33 9.39e-10 Total body bone mineral density; CRC cis rs12477438 0.765 rs6542846 chr2:99563654 T/C cg26064155 chr2:99771622 LIPT1;TSGA10 -0.62 -8.56 -0.43 4.41e-16 Chronic sinus infection; CRC cis rs2932538 0.922 rs61818800 chr1:113148571 A/G cg22162597 chr1:113214053 CAPZA1 0.69 9.5 0.46 4.47e-19 Systolic blood pressure;Diastolic blood pressure;Hypertension;Blood pressure; CRC cis rs6088580 0.567 rs6088520 chr20:33132364 A/G cg08999081 chr20:33150536 PIGU -0.59 -10.83 -0.51 1.4e-23 Glomerular filtration rate (creatinine); CRC cis rs12745968 0.623 rs4847432 chr1:93118884 C/G cg17283838 chr1:93427260 FAM69A -0.44 -6.15 -0.32 2.26e-9 Bipolar disorder and schizophrenia; CRC cis rs7618915 0.501 rs767418 chr3:52767427 C/T cg10802521 chr3:52805072 NEK4 -0.57 -8.87 -0.44 4.63e-17 Bipolar disorder; CRC cis rs875971 0.545 rs67397473 chr7:65633305 A/G cg05627663 chr7:65219948 SNORA22;CCT6P1 0.6 7.89 0.4 4.49e-14 Aortic root size; CRC cis rs9487051 0.872 rs7773331 chr6:109609208 C/T cg12927641 chr6:109611667 NA -0.38 -6.97 -0.36 1.78e-11 Reticulocyte fraction of red cells; CRC cis rs7527798 0.592 rs960087 chr1:207826858 C/G cg21110645 chr1:207815933 NA -0.41 -6.27 -0.33 1.14e-9 Erythrocyte sedimentation rate; CRC cis rs9527 0.590 rs7088200 chr10:104793235 G/A cg04362960 chr10:104952993 NT5C2 0.59 8.36 0.42 1.81e-15 Arsenic metabolism; CRC cis rs1552244 1.000 rs6781811 chr3:10121922 A/G cg02579736 chr3:10068473 FANCD2;CIDECP -0.97 -13.08 -0.58 9.29e-32 Alzheimer's disease; CRC cis rs6540559 0.673 rs17015183 chr1:209948711 A/C cg25204440 chr1:209979598 IRF6 0.49 5.88 0.31 1.01e-8 Cleft lip with or without cleft palate; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg10959773 chr22:24951920 C22orf13;SNRPD3 0.49 6.27 0.33 1.13e-9 Thyroid stimulating hormone; CRC cis rs1192419 0.502 rs6686665 chr1:92056435 C/T cg24006770 chr1:92056542 NA 0.57 9.56 0.47 2.97e-19 Optic disc area;Optic nerve measurement (cup-to-disc ratio); CRC cis rs1153858 1.000 rs4775937 chr15:45678614 C/A cg21132104 chr15:45694354 SPATA5L1 0.57 8.24 0.41 4.06e-15 Homoarginine levels; CRC cis rs9926296 0.605 rs8047486 chr16:89854025 A/T cg27121462 chr16:89883253 FANCA 0.57 9.06 0.45 1.19e-17 Vitiligo; CRC cis rs2019137 0.901 rs4849176 chr2:113977936 C/T cg12889195 chr2:113992843 PAX8;LOC440839;LOC654433 -0.5 -7.23 -0.37 3.47e-12 Lymphocyte counts; CRC cis rs875971 0.545 rs73146609 chr7:65767464 A/G cg11764359 chr7:65958608 NA 0.46 5.77 0.3 1.83e-8 Aortic root size; CRC cis rs4689592 0.503 rs10516184 chr4:7060959 C/T cg26116260 chr4:7069785 GRPEL1 0.84 10.25 0.49 1.36e-21 Monocyte percentage of white cells; CRC cis rs769267 0.965 rs12977937 chr19:19429975 C/G cg20644253 chr19:19431407 KIAA0892;SF4 0.42 5.84 0.31 1.23e-8 Tonsillectomy; CRC cis rs995000 0.931 rs10889339 chr1:63012056 A/G cg19896129 chr1:63156450 NA -0.44 -6.92 -0.36 2.4e-11 Triglyceride levels; CRC cis rs2302777 0.507 rs9889716 chr17:38108298 A/G cg26162295 chr17:38119207 GSDMA -0.34 -5.67 -0.3 3.09e-8 Multiple myeloma (hyperdiploidy); CRC cis rs2288073 0.801 rs10176347 chr2:24367994 G/A cg06627628 chr2:24431161 ITSN2 -0.54 -7.96 -0.4 2.77e-14 Venous thromboembolism (SNP x SNP interaction); CRC cis rs7777484 0.534 rs2533888 chr7:2831083 T/C cg19717773 chr7:2847554 GNA12 -0.52 -9.23 -0.45 3.44e-18 Height; CRC cis rs9296092 0.538 rs112113649 chr6:33524529 A/G cg13560919 chr6:33536144 NA -0.44 -6.2 -0.32 1.73e-9 Age at smoking initiation in chronic obstructive pulmonary disease; CRC cis rs13118159 0.556 rs4974615 chr4:1373551 A/G cg16405210 chr4:1374714 KIAA1530 0.91 15.03 0.64 2.98e-39 Longevity; CRC cis rs939658 0.935 rs12903747 chr15:79449627 A/C cg17916960 chr15:79447300 NA 0.46 7.56 0.38 3.94e-13 Refractive error; CRC trans rs1814175 0.607 rs11493324 chr11:50011304 T/C cg11707556 chr5:10655725 ANKRD33B -0.38 -7.1 -0.36 7.73e-12 Height; CRC cis rs3087591 1.000 rs8082020 chr17:29694795 G/A cg24425628 chr17:29625626 OMG;NF1 -0.78 -14.34 -0.62 1.42e-36 Hip circumference; CRC cis rs7412746 0.611 rs3768018 chr1:150723747 T/C cg15448220 chr1:150897856 SETDB1 0.51 7.02 0.36 1.26e-11 Melanoma; CRC cis rs2228479 0.850 rs17226980 chr16:89825065 G/A cg19635926 chr16:89946313 TCF25 0.63 5.68 0.3 3.01e-8 Skin colour saturation; CRC cis rs9325144 0.555 rs4882279 chr12:38688918 C/A cg13010199 chr12:38710504 ALG10B 0.41 6.02 0.32 4.61e-9 Morning vs. evening chronotype; CRC cis rs561341 0.830 rs2301765 chr17:30202056 T/A cg23018236 chr17:30244563 NA 0.53 6.72 0.35 7.79e-11 Hip circumference adjusted for BMI; CRC cis rs11958404 0.932 rs12514557 chr5:157418954 T/C cg05962755 chr5:157440814 NA 0.84 11.22 0.53 5.68e-25 IgG glycosylation; CRC cis rs4965359 0.750 rs2995904 chr15:101595898 A/G cg01350081 chr15:101592003 LRRK1 0.36 6.23 0.32 1.46e-9 Central corneal thickness; CRC cis rs10751667 0.666 rs7943140 chr11:973824 T/C cg23136738 chr11:925521 AP2A2 -0.42 -7.09 -0.36 8.01e-12 Alzheimer's disease (late onset); CRC cis rs10540 1.000 rs61877775 chr11:521462 C/T cg03576123 chr11:487126 PTDSS2 -1.1 -10.87 -0.51 1.04e-23 Body mass index; CRC cis rs2811415 0.597 rs9833838 chr3:127741134 C/G cg13719885 chr3:127795394 NA -0.36 -5.62 -0.3 4.1e-8 Lung function (FEV1/FVC); CRC cis rs2380220 0.678 rs4308568 chr6:96009525 A/C cg23517279 chr6:96025343 MANEA -0.5 -5.72 -0.3 2.42e-8 Behavioural disinhibition (generation interaction); CRC cis rs9549328 0.544 rs66893681 chr13:113617499 A/G cg25790453 chr13:113633590 MCF2L 0.44 7.62 0.39 2.7e-13 Systolic blood pressure; CRC cis rs6964587 0.967 rs10279943 chr7:91587477 G/C cg17063962 chr7:91808500 NA 0.81 14.22 0.62 4.3e-36 Breast cancer; CRC cis rs12477438 0.798 rs1530996 chr2:99584079 T/C cg26064155 chr2:99771622 LIPT1;TSGA10 -0.77 -10.91 -0.52 7.49e-24 Chronic sinus infection; CRC cis rs6840360 0.593 rs6855883 chr4:152688997 A/G cg22705602 chr4:152727874 NA -0.35 -5.93 -0.31 7.82e-9 Intelligence (multi-trait analysis); CRC cis rs13108904 0.935 rs1732100 chr4:1281761 C/T cg21620606 chr4:1342894 KIAA1530 -0.41 -7.26 -0.37 2.84e-12 Obesity-related traits; CRC cis rs11122272 0.735 rs2808595 chr1:231526238 G/A cg06096015 chr1:231504339 EGLN1 0.4 6.07 0.32 3.43e-9 Hemoglobin concentration; CRC cis rs2153535 0.525 rs1335644 chr6:8488041 A/G cg21535247 chr6:8435926 SLC35B3 0.5 7.54 0.38 4.72e-13 Motion sickness; CRC cis rs9399135 0.967 rs13199205 chr6:135286505 T/C cg22676075 chr6:135203613 NA 0.41 6.22 0.32 1.47e-9 Red blood cell count; CRC cis rs208515 0.525 rs1351866 chr6:66696969 A/G cg07460842 chr6:66804631 NA 0.97 12.38 0.56 3.56e-29 Exhaled nitric oxide levels; CRC cis rs4713118 0.539 rs200967 chr6:27862127 A/G cg21251018 chr6:28226885 NKAPL 0.53 8.06 0.41 1.42e-14 Parkinson's disease; CRC cis rs9660180 0.967 rs6664664 chr1:1751264 G/A cg23982607 chr1:1823379 GNB1 -0.88 -15.94 -0.66 8.97e-43 Body mass index; CRC cis rs780096 0.526 rs780106 chr2:27681598 A/C cg21248554 chr2:27665150 KRTCAP3 -0.33 -7.82 -0.4 7.44e-14 Total body bone mineral density; CRC cis rs62064224 0.614 rs728718 chr17:30708960 T/G cg12855166 chr17:30846586 MYO1D -0.35 -5.67 -0.3 3.14e-8 Schizophrenia; CRC cis rs6502050 0.765 rs6502074 chr17:80121776 T/C cg09264619 chr17:80180166 NA -0.37 -6.2 -0.32 1.72e-9 Life satisfaction; CRC cis rs4908768 0.539 rs6663123 chr1:8642931 T/C cg20416874 chr1:8611966 RERE -0.43 -6.11 -0.32 2.81e-9 Neuroticism (multi-trait analysis);Subjective well-being (multi-trait analysis); CRC cis rs4555082 0.957 rs2975216 chr14:105713134 T/C cg06808227 chr14:105710500 BRF1 -0.62 -9.51 -0.46 4.03e-19 Mean platelet volume;Platelet distribution width; CRC cis rs75804782 0.691 rs55886641 chr2:239319185 T/C cg18131467 chr2:239335373 ASB1 -0.7 -6.06 -0.32 3.71e-9 Morning vs. evening chronotype;Chronotype; CRC cis rs9733 0.596 rs11204687 chr1:150629880 C/A cg15448220 chr1:150897856 SETDB1 0.45 6.43 0.33 4.42e-10 Tonsillectomy; CRC cis rs11764590 0.694 rs60626033 chr7:2099719 A/G cg14004847 chr7:1930337 MAD1L1 -0.42 -5.67 -0.3 3.15e-8 Neuroticism; CRC cis rs9649213 0.555 rs34695842 chr7:97931062 G/T cg24562669 chr7:97807699 LMTK2 0.44 7.28 0.37 2.45e-12 Prostate cancer (SNP x SNP interaction); CRC cis rs4319547 0.697 rs7974262 chr12:122896385 C/T cg23029597 chr12:123009494 RSRC2 0.6 7.45 0.38 8.41e-13 Body mass index; CRC cis rs6545883 0.929 rs7606167 chr2:61742654 C/G cg15711740 chr2:61764176 XPO1 -0.52 -7.2 -0.37 4.03e-12 Tuberculosis; CRC cis rs7119 0.717 rs12917314 chr15:77818285 T/C cg10437265 chr15:77819839 NA 0.69 12.74 0.57 1.76e-30 Type 2 diabetes; CRC cis rs782590 0.967 rs10496050 chr2:55806313 C/T cg18811423 chr2:55921094 PNPT1 0.79 14.71 0.63 5.35e-38 Metabolic syndrome; CRC cis rs713587 0.624 rs1550110 chr2:25124563 T/C cg22495460 chr2:25135724 ADCY3 -0.87 -17.16 -0.69 1.36e-47 Body mass index in non-asthmatics; CRC trans rs3780486 0.846 rs6476399 chr9:33123013 A/G cg04842962 chr6:43655489 MRPS18A 1.16 25.81 0.82 4.38e-81 IgG glycosylation; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg13917047 chr17:15406213 FAM18B2 0.38 6.01 0.31 4.96e-9 Liver disease severity in Alagille syndrome; CRC cis rs13108904 0.901 rs7668661 chr4:1300172 A/G cg23123621 chr4:1343375 KIAA1530 0.35 6.42 0.33 4.68e-10 Obesity-related traits; CRC cis rs17021463 0.615 rs4626213 chr4:95297241 G/A cg11021082 chr4:95130006 SMARCAD1 0.48 7.28 0.37 2.52e-12 Testicular germ cell tumor; CRC trans rs2243480 1.000 rs9769882 chr7:65642925 T/C cg10756647 chr7:56101905 PSPH -0.76 -7.87 -0.4 5.31e-14 Diabetic kidney disease; CRC cis rs853679 0.542 rs6934769 chr6:28090931 A/G cg18032046 chr6:28092343 ZSCAN16 -0.52 -6.08 -0.32 3.3e-9 Depression; CRC cis rs4929949 0.932 rs10840087 chr11:8616255 G/A cg17679104 chr11:8615758 STK33 0.38 6.41 0.33 5.17e-10 Body mass index; CRC cis rs826838 1.000 rs11610522 chr12:38687575 C/T cg13010199 chr12:38710504 ALG10B 0.48 6.24 0.33 1.33e-9 Heart rate; CRC cis rs17711722 0.523 rs313812 chr7:65505043 T/C cg07294406 chr7:64700536 NA -0.39 -6.36 -0.33 6.66e-10 Calcium levels; CRC cis rs6754311 0.773 rs1435576 chr2:136641882 A/T cg15123519 chr2:136567270 LCT -0.35 -6.78 -0.35 5.44e-11 Mosquito bite size; CRC cis rs4604732 0.631 rs34330532 chr1:247626844 G/C cg02104434 chr1:247694406 LOC148824;OR2C3 0.6 8.82 0.44 6.67e-17 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CRC cis rs4242434 0.892 rs11776549 chr8:22493124 C/T cg03733263 chr8:22462867 KIAA1967 0.98 15.98 0.66 6.1e-43 Exploratory eye movement dysfunction in schizophrenia (cognitive search score); CRC cis rs4975616 0.804 rs456366 chr5:1337070 T/C cg06550200 chr5:1325588 CLPTM1L -0.72 -11.33 -0.53 2.37e-25 Lung cancer; CRC cis rs7617773 0.780 rs6793223 chr3:48364101 C/T cg11946769 chr3:48343235 NME6 0.72 9.58 0.47 2.48e-19 Coronary artery disease; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg17340548 chr19:46185070 GIPR 0.36 6.0 0.31 5.21e-9 Liver disease severity in Alagille syndrome; CRC cis rs1784581 0.928 rs1789995 chr6:162396518 C/T cg17173639 chr6:162384350 PARK2 -0.8 -14.48 -0.62 4.33e-37 Itch intensity from mosquito bite; CRC cis rs6502050 0.799 rs58538819 chr17:80107153 G/C cg13198984 chr17:80129470 CCDC57 0.47 8.18 0.41 6.33e-15 Life satisfaction; CRC cis rs10045504 0.502 rs17456482 chr5:38737783 G/C cg15396434 chr5:38725168 NA -0.6 -5.99 -0.31 5.54e-9 Night sleep phenotypes; CRC cis rs873946 0.648 rs3793673 chr10:134547732 A/C cg18305652 chr10:134549665 INPP5A 0.54 7.28 0.37 2.42e-12 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CRC cis rs10504229 0.683 rs11774697 chr8:58133119 G/A cg02725872 chr8:58115012 NA -0.58 -8.39 -0.42 1.5e-15 Developmental language disorder (linguistic errors); CRC cis rs1697139 0.935 rs1623654 chr5:66512819 A/T cg16691251 chr5:66510806 NA 0.59 11.66 0.54 1.6e-26 Breast cancer; CRC cis rs6570726 0.577 rs9497315 chr6:145791967 C/T cg23711669 chr6:146136114 FBXO30 -0.61 -8.96 -0.44 2.54e-17 Lobe attachment (rater-scored or self-reported); CRC cis rs2404602 0.647 rs10851892 chr15:77176491 T/C cg03037974 chr15:76606532 NA -0.53 -7.45 -0.38 8.24e-13 Blood metabolite levels; CRC cis rs10504073 0.647 rs55920380 chr8:50026353 G/A cg00325661 chr8:49890786 NA 0.52 9.28 0.46 2.31e-18 Blood metabolite ratios; CRC cis rs2075371 0.932 rs2598290 chr7:133987736 C/G cg20476274 chr7:133979776 SLC35B4 0.82 15.11 0.64 1.57e-39 Mean platelet volume; CRC cis rs1799949 1.000 rs33945274 chr17:41280073 G/A cg05368731 chr17:41323189 NBR1 0.69 10.48 0.5 2.22e-22 Menopause (age at onset); CRC cis rs9467711 0.659 rs35304979 chr6:26356347 C/A cg16898833 chr6:26189333 HIST1H4D 0.75 6.55 0.34 2.26e-10 Autism spectrum disorder or schizophrenia; CRC trans rs7647973 0.710 rs2029591 chr3:49646981 C/T cg21665057 chr3:196295764 WDR53;FBXO45 0.61 6.64 0.34 1.3100000000000001e-10 Menarche (age at onset); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg12463199 chr20:49126897 PTPN1 0.44 6.07 0.32 3.48e-9 Response to antipsychotic treatment; CRC trans rs10842750 1.000 rs10842750 chr12:26690565 G/T cg24669129 chr7:155089712 INSIG1 0.47 5.97 0.31 6.26e-9 Kashin-Beck disease; CRC cis rs939658 0.805 rs2177056 chr15:79441489 T/C cg17916960 chr15:79447300 NA -0.44 -7.1 -0.36 7.68e-12 Refractive error; CRC cis rs7412746 0.611 rs111842513 chr1:150712926 G/A cg18016565 chr1:150552671 MCL1 0.46 6.53 0.34 2.53e-10 Melanoma; CRC cis rs4746818 1.000 rs7893492 chr10:70960448 C/T cg11621586 chr10:70884670 VPS26A -0.89 -7.94 -0.4 3.26e-14 Left atrial antero-posterior diameter; CRC cis rs9612 1.000 rs61002661 chr19:44269032 T/A cg08581076 chr19:44259116 C19orf61 0.48 6.12 0.32 2.64e-9 Exhaled nitric oxide output; CRC cis rs40363 1.000 rs1635393 chr16:3520493 C/T cg05754148 chr16:3507555 NAT15 0.75 8.35 0.42 1.93e-15 Tuberculosis; CRC cis rs5753618 0.519 rs5997939 chr22:31677130 C/G cg22777020 chr22:31556080 RNF185 -0.51 -5.82 -0.31 1.42e-8 Colorectal cancer; CRC cis rs4819052 0.819 rs34818688 chr21:46672416 C/T cg02159808 chr21:46707872 POFUT2;LOC642852 0.5 6.67 0.35 1.06e-10 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs1593 0.734 rs4862670 chr4:187145423 A/T cg09526685 chr4:187126073 CYP4V2 0.45 6.51 0.34 2.78e-10 Activated partial thromboplastin time; CRC cis rs1878931 0.582 rs27227 chr16:3429778 G/A cg02880119 chr16:3481970 NA 0.42 6.0 0.31 5.3e-9 Body mass index (adult); CRC cis rs57221529 0.766 rs4081847 chr5:574072 C/T cg17948913 chr5:572064 NA 0.55 6.42 0.33 4.65e-10 Lung disease severity in cystic fibrosis; CRC cis rs7937682 0.562 rs12275761 chr11:111367083 T/A cg09085632 chr11:111637200 PPP2R1B 0.57 8.18 0.41 6.29e-15 Primary sclerosing cholangitis; CRC cis rs6024905 0.595 rs2022499 chr20:36966531 G/T cg07053727 chr20:36965646 BPI 0.74 14.21 0.62 4.54e-36 Bipolar disorder and schizophrenia; CRC cis rs1129187 0.967 rs11752813 chr6:42928017 C/G cg27588902 chr6:42928151 GNMT -0.38 -6.72 -0.35 8.19e-11 Alzheimer's disease in APOE e4+ carriers; CRC cis rs1865760 0.551 rs9461230 chr6:26019240 G/C cg16482183 chr6:26056742 HIST1H1C 0.51 7.55 0.38 4.29e-13 Height; CRC cis rs1799949 1.000 rs11653231 chr17:41331460 G/A cg25072359 chr17:41440525 NA 0.46 6.94 0.36 2.07e-11 Menopause (age at onset); CRC cis rs9488822 0.702 rs10872141 chr6:116323246 C/A cg15226275 chr6:116381976 FRK 0.3 8.49 0.42 7.39e-16 Cholesterol, total;LDL cholesterol; CRC cis rs7932354 0.528 rs7121418 chr11:47165106 G/A cg03339077 chr11:47165057 C11orf49 0.5 7.25 0.37 3.06e-12 Bone mineral density (hip);Bone mineral density; CRC cis rs1580019 0.522 rs10951340 chr7:32562408 G/A cg06627557 chr7:32535165 LSM5;AVL9 0.95 17.67 0.7 1.31e-49 Cognitive ability; CRC cis rs1023500 0.505 rs134878 chr22:42663874 A/G cg04733989 chr22:42467013 NAGA 0.5 7.28 0.37 2.47e-12 Schizophrenia; CRC trans rs11466653 1.000 rs10002420 chr4:38779213 T/A cg11403706 chr22:49042600 FAM19A5 0.62 6.11 0.32 2.76e-9 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs889398 0.802 rs8050414 chr16:69886813 T/A cg00738113 chr16:70207722 CLEC18C -0.37 -6.23 -0.32 1.41e-9 Body mass index; CRC cis rs12142240 0.698 rs1475389 chr1:46816429 T/C cg14993813 chr1:46806288 NSUN4 -0.5 -6.4 -0.33 5.38e-10 Menopause (age at onset); CRC cis rs4731207 0.565 rs2402760 chr7:124595920 C/T cg23710748 chr7:124431027 NA -0.39 -6.14 -0.32 2.34e-9 Cutaneous malignant melanoma; CRC trans rs11098499 0.908 rs9995234 chr4:120321827 A/G cg25214090 chr10:38739885 LOC399744 0.64 9.95 0.48 1.5e-20 Corneal astigmatism; CRC cis rs6580649 0.943 rs1859444 chr12:48399403 T/C cg05342945 chr12:48394962 COL2A1 -0.43 -6.03 -0.32 4.36e-9 Lung cancer; CRC cis rs7113874 0.550 rs4929949 chr11:8604593 T/C cg02811074 chr11:8615871 STK33 0.35 6.06 0.32 3.76e-9 Body mass index in physically active individuals;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs28386778 0.897 rs2854213 chr17:61945631 T/C cg06873352 chr17:61820015 STRADA 0.76 14.25 0.62 3.31e-36 Prudent dietary pattern; CRC cis rs6762 0.719 rs1130698 chr11:838542 C/T cg15787769 chr11:842744 TSPAN4;POLR2L -0.46 -6.38 -0.33 6.06e-10 Mean platelet volume; CRC cis rs4862750 0.872 rs6830426 chr4:187897270 T/A cg07414643 chr4:187882934 NA 0.4 6.98 0.36 1.59e-11 Lobe attachment (rater-scored or self-reported); CRC cis rs10504229 0.639 rs11781834 chr8:58133422 C/T cg24829409 chr8:58192753 C8orf71 -0.55 -8.01 -0.4 1.96e-14 Developmental language disorder (linguistic errors); CRC cis rs2976388 0.609 rs2717602 chr8:143805683 G/A cg20041105 chr8:143859282 LYNX1 0.44 7.87 0.4 5.27e-14 Urinary tract infection frequency; CRC cis rs1799949 0.965 rs799916 chr17:41243190 G/T cg23758822 chr17:41437982 NA -0.85 -15.69 -0.65 8.63e-42 Menopause (age at onset); CRC cis rs11098499 0.863 rs1383532 chr4:120434404 A/T cg09307838 chr4:120376055 NA -0.66 -10.08 -0.49 5.12e-21 Corneal astigmatism; CRC cis rs910316 1.000 rs175442 chr14:75603564 T/C cg03030879 chr14:75389066 RPS6KL1 0.46 7.29 0.37 2.27e-12 Height; CRC cis rs7811142 0.666 rs28401739 chr7:99905684 A/G cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.81 10.23 0.49 1.68e-21 Platelet count; CRC cis rs2380220 0.935 rs7748857 chr6:96001887 A/G cg04719120 chr6:96025338 MANEA 0.63 7.21 0.37 3.84e-12 Behavioural disinhibition (generation interaction); CRC cis rs9322193 0.884 rs2342858 chr6:150127103 C/T cg13206674 chr6:150067644 NUP43 0.56 7.95 0.4 2.97e-14 Lung cancer; CRC cis rs694739 0.657 rs11231770 chr11:64140625 G/A cg23796481 chr11:64053134 BAD;GPR137 0.48 6.65 0.34 1.21e-10 Alopecia areata;Crohn's disease;Psoriasis vulgaris; CRC cis rs9311474 0.539 rs12489828 chr3:52567014 G/T cg10802521 chr3:52805072 NEK4 -0.41 -6.55 -0.34 2.27e-10 Electroencephalogram traits; CRC cis rs9916302 0.706 rs28482878 chr17:37497100 A/G cg00129232 chr17:37814104 STARD3 0.58 7.21 0.37 3.86e-12 Glomerular filtration rate (creatinine); CRC trans rs1005277 0.579 rs176880 chr10:38401417 C/G cg17830980 chr10:43048298 ZNF37B 0.6 9.96 0.48 1.36e-20 Extrinsic epigenetic age acceleration; CRC cis rs10504229 0.953 rs115634610 chr8:58190533 G/A cg02725872 chr8:58115012 NA -0.38 -6.42 -0.33 4.72e-10 Developmental language disorder (linguistic errors); CRC cis rs6952808 0.965 rs4719318 chr7:1887930 G/A cg04267008 chr7:1944627 MAD1L1 -0.71 -10.52 -0.5 1.62e-22 Bipolar disorder and schizophrenia; CRC cis rs763121 0.853 rs9610993 chr22:39042818 C/A cg06544989 chr22:39130855 UNC84B 0.44 6.84 0.35 3.76e-11 Menopause (age at onset); CRC cis rs3015497 0.653 rs2356455 chr14:51093142 G/A cg09863266 chr14:51125203 SAV1 -0.3 -5.75 -0.3 2.09e-8 Mean platelet volume; CRC cis rs17125944 0.615 rs17125798 chr14:53319905 G/A cg00686598 chr14:53173677 PSMC6 0.87 7.31 0.37 2.08e-12 Alzheimer's disease (late onset); CRC cis rs7739232 0.920 rs7748828 chr6:53517643 A/C cg15658676 chr6:53530538 KLHL31 -0.75 -5.88 -0.31 1.03e-8 Hip circumference adjusted for BMI; CRC cis rs2075371 1.000 rs1862051 chr7:133981021 G/A cg20476274 chr7:133979776 SLC35B4 0.81 14.72 0.63 4.99e-38 Mean platelet volume; CRC cis rs2576037 0.583 rs641366 chr18:44430326 C/T cg19077165 chr18:44547161 KATNAL2 -0.62 -10.63 -0.51 7.02e-23 Personality dimensions; CRC cis rs7580658 0.613 rs12478656 chr2:128196520 G/T cg09760422 chr2:128146352 NA -0.31 -5.67 -0.3 3.15e-8 Protein C levels; CRC cis rs28386778 0.704 rs1051688 chr17:62006433 G/C cg11494091 chr17:61959527 GH2 -0.65 -11.53 -0.54 4.59e-26 Prudent dietary pattern; CRC trans rs11088226 0.681 rs2833912 chr21:33949822 G/A cg09050820 chr6:167586206 TCP10L2 0.9 9.58 0.47 2.4e-19 Gastritis; CRC trans rs9291683 0.526 rs12506122 chr4:10033538 C/A cg26043149 chr18:55253948 FECH 0.51 7.5 0.38 5.85e-13 Bone mineral density; CRC cis rs6429082 0.714 rs704719 chr1:235667170 G/A cg26050004 chr1:235667680 B3GALNT2 0.57 7.68 0.39 1.79e-13 Adiposity; CRC cis rs7635838 0.587 rs1992910 chr3:11311942 C/T cg00170343 chr3:11313890 ATG7 0.59 9.22 0.45 3.77e-18 HDL cholesterol; CRC cis rs9443645 0.527 rs12196485 chr6:79556871 A/G cg09184832 chr6:79620586 NA -0.46 -8.03 -0.4 1.7e-14 Intelligence (multi-trait analysis); CRC cis rs1707322 1.000 rs1612419 chr1:46546945 T/C cg06784218 chr1:46089804 CCDC17 -0.61 -10.54 -0.5 1.37e-22 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs60871478 0.787 rs4720928 chr7:808002 T/C cg13844804 chr7:814759 HEATR2 0.6 7.94 0.4 3.33e-14 Cerebrospinal P-tau181p levels; CRC cis rs6546550 0.901 rs13028508 chr2:70118427 A/T cg02498382 chr2:70120550 SNRNP27 0.54 8.98 0.44 2.07e-17 Prevalent atrial fibrillation; CRC cis rs2996428 0.667 rs10492942 chr1:3764216 C/T cg17848003 chr1:3704513 LRRC47 0.42 6.01 0.31 4.81e-9 Red cell distribution width; CRC trans rs1656966 1.000 rs1656966 chr3:186466252 C/T cg17302176 chr4:139936680 CCRN4L 0.41 6.11 0.32 2.88e-9 Myopia (pathological); CRC cis rs9611565 0.512 rs139571 chr22:42214238 G/A cg17554472 chr22:41940697 POLR3H -0.6 -6.08 -0.32 3.24e-9 Vitiligo; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg16237672 chr18:74534576 NA 0.37 6.43 0.33 4.61e-10 Liver disease severity in Alagille syndrome; CRC cis rs4629180 1.000 rs13031791 chr2:102108790 T/C cg04415270 chr2:102091202 RFX8 0.59 8.0 0.4 2.17e-14 Chronic rhinosinusitis with nasal polyps; CRC cis rs4930103 0.904 rs2067051 chr11:2018168 C/T cg06197492 chr11:2016605 H19 0.42 6.51 0.34 2.78e-10 DNA methylation (parent-of-origin);DNA methylation (variation); CRC cis rs4819052 0.851 rs2330012 chr21:46658592 G/A cg02159808 chr21:46707872 POFUT2;LOC642852 0.49 6.41 0.33 5.19e-10 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs61774743 0.681 rs10889959 chr1:41849735 T/C cg00290994 chr1:41848739 NA 0.53 7.99 0.4 2.34e-14 Intelligence (multi-trait analysis); CRC cis rs16936870 0.543 rs877181 chr8:71077288 G/A cg14232793 chr8:71155543 NCOA2 -0.46 -5.72 -0.3 2.36e-8 QT interval; CRC cis rs6424115 0.800 rs6665733 chr1:24200158 T/C cg09473613 chr1:24152604 HMGCL 0.35 5.75 0.3 1.99e-8 Immature fraction of reticulocytes; CRC cis rs7927771 0.965 rs4752845 chr11:47539697 T/C cg18512352 chr11:47633146 NA -0.48 -9.49 -0.46 4.89e-19 Subjective well-being; CRC cis rs765787 0.530 rs2554454 chr15:45521536 A/G cg24006582 chr15:45444508 DUOX1 -0.53 -8.04 -0.41 1.69e-14 Uric acid levels; CRC cis rs9733 0.596 rs6678013 chr1:150623285 T/G cg10589385 chr1:150898437 SETDB1 0.28 5.98 0.31 5.86e-9 Tonsillectomy; CRC cis rs738322 0.775 rs4375 chr22:38539041 T/C cg25457927 chr22:38595422 NA -0.33 -6.93 -0.36 2.24e-11 Cutaneous nevi; CRC cis rs9486719 0.947 rs11755945 chr6:96908038 G/C cg06623918 chr6:96969491 KIAA0776 -0.81 -9.32 -0.46 1.72e-18 Migraine;Coronary artery disease; CRC cis rs10540 0.730 rs61877766 chr11:512973 T/G cg03576123 chr11:487126 PTDSS2 -1.04 -10.78 -0.51 2.09e-23 Body mass index; CRC cis rs7772486 0.743 rs9403742 chr6:146060193 A/C cg23711669 chr6:146136114 FBXO30 0.65 10.96 0.52 4.79e-24 Lobe attachment (rater-scored or self-reported); CRC cis rs9768139 0.935 rs7809076 chr7:158118438 C/T cg23298862 chr7:158159286 PTPRN2 -0.47 -7.86 -0.4 5.65e-14 Calcium levels; CRC cis rs6502050 0.835 rs4789738 chr17:80123053 G/A cg11859384 chr17:80120422 CCDC57 -0.36 -5.75 -0.3 2.06e-8 Life satisfaction; CRC cis rs780096 0.587 rs10205219 chr2:27568565 T/C cg24768116 chr2:27665128 KRTCAP3 -0.32 -7.13 -0.37 6.28e-12 Total body bone mineral density; CRC cis rs1223397 0.702 rs1223400 chr6:13271242 T/C cg00460589 chr6:13274354 PHACTR1 0.47 5.79 0.3 1.61e-8 Blood pressure; CRC cis rs8114671 0.562 rs2378292 chr20:33485178 T/C cg07148914 chr20:33460835 GGT7 0.46 7.2 0.37 4.14e-12 Height; CRC cis rs6951245 0.580 rs77101766 chr7:1122438 A/G cg20603222 chr7:1096387 C7orf50;GPR146 -0.47 -5.95 -0.31 6.73e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs9372498 0.536 rs62663261 chr6:118900553 T/C cg22561889 chr6:118971681 C6orf204 0.47 5.9 0.31 9.09e-9 Diastolic blood pressure; CRC cis rs4713118 0.621 rs9368548 chr6:28034737 A/G cg06470822 chr6:28175283 NA 0.94 12.75 0.58 1.6e-30 Parkinson's disease; CRC cis rs1003719 0.713 rs2835594 chr21:38466064 G/A cg10648535 chr21:38446584 PIGP;TTC3 0.52 7.41 0.38 1.07e-12 Eye color traits; CRC cis rs9894429 0.682 rs7406360 chr17:79591545 G/A cg18240062 chr17:79603768 NPLOC4 0.67 11.92 0.55 1.86e-27 Eye color traits; CRC cis rs12760731 0.623 rs721289 chr1:178395682 A/G cg00404053 chr1:178313656 RASAL2 0.72 8.51 0.42 6.38e-16 Obesity-related traits; CRC cis rs372883 0.638 rs117213 chr21:30720536 G/A cg24692254 chr21:30365293 RNF160 -0.63 -9.45 -0.46 6.37e-19 Pancreatic cancer; CRC cis rs11025559 0.812 rs10833338 chr11:20514709 A/G cg19653624 chr11:20408972 PRMT3 -0.62 -7.53 -0.38 4.9e-13 Pursuit maintenance gain; CRC cis rs12188164 0.965 rs72717438 chr5:448663 C/T cg16322479 chr5:444228 EXOC3;C5orf55 0.5 8.06 0.41 1.43e-14 Cystic fibrosis severity; CRC cis rs6952808 0.782 rs4236271 chr7:1881369 C/T cg14004847 chr7:1930337 MAD1L1 -0.41 -5.98 -0.31 5.95e-9 Bipolar disorder and schizophrenia; CRC cis rs6693567 0.545 rs1566225 chr1:150415990 G/C cg15654264 chr1:150340011 RPRD2 0.42 6.25 0.33 1.29e-9 Migraine; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg22159483 chr17:1588198 PRPF8 0.52 6.78 0.35 5.61e-11 Thyroid stimulating hormone; CRC cis rs3791406 0.963 rs3791408 chr2:240030591 C/T cg14550559 chr2:240039617 HDAC4 -0.52 -7.81 -0.4 7.89e-14 Skin aging (microtopography measurement); CRC cis rs7666738 0.830 rs3846443 chr4:99032666 G/A cg17366294 chr4:99064904 C4orf37 0.44 7.43 0.38 9.22e-13 Colonoscopy-negative controls vs population controls; CRC cis rs2288912 0.838 rs7251503 chr19:45455715 C/G cg13119609 chr19:45449297 APOC2 0.31 5.81 0.3 1.5e-8 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs1958560 0.932 rs61987992 chr14:66070731 C/T cg03016385 chr14:66212404 NA -0.45 -6.19 -0.32 1.81e-9 Menarche (age at onset); CRC cis rs9916302 0.861 rs9903363 chr17:37499604 C/G cg07936489 chr17:37558343 FBXL20 0.84 13.2 0.59 3.12e-32 Glomerular filtration rate (creatinine); CRC cis rs274567 0.501 rs272855 chr5:131687175 C/T cg04518342 chr5:131593106 PDLIM4 0.43 6.85 0.35 3.61e-11 Blood metabolite levels; CRC cis rs7811142 1.000 rs2406253 chr7:100077273 A/G cg00814883 chr7:100076585 TSC22D4 -0.74 -9.4 -0.46 9.54e-19 Platelet count; CRC cis rs11098499 0.908 rs9995234 chr4:120321827 A/G cg24375607 chr4:120327624 NA 0.52 7.89 0.4 4.4e-14 Corneal astigmatism; CRC cis rs7605827 0.930 rs7598196 chr2:15596662 A/G cg19274914 chr2:15703543 NA 0.39 6.03 0.32 4.51e-9 Educational attainment (years of education); CRC cis rs4077468 1.000 rs4077469 chr1:205914885 C/T cg13172432 chr1:205912842 SLC26A9 -0.35 -6.11 -0.32 2.76e-9 Cystic fibrosis-related diabetes; CRC cis rs2976388 0.507 rs2572874 chr8:143837219 C/T cg05569086 chr8:143859399 LYNX1 0.51 8.88 0.44 4.46e-17 Urinary tract infection frequency; CRC cis rs1448094 0.740 rs4919774 chr12:86337560 G/T cg02569458 chr12:86230093 RASSF9 0.46 7.79 0.39 8.84e-14 Major depressive disorder; CRC cis rs1129187 0.935 rs9986447 chr6:42942779 C/T cg02353165 chr6:42928485 GNMT -0.86 -15.33 -0.65 2.13e-40 Alzheimer's disease in APOE e4+ carriers; CRC cis rs6540559 1.000 rs4844895 chr1:209958580 T/C cg21951975 chr1:209979733 IRF6 0.46 6.79 0.35 5.38e-11 Cleft lip with or without cleft palate; CRC cis rs12497850 0.931 rs7636057 chr3:48992582 C/T cg20833759 chr3:49053208 WDR6;DALRD3 0.54 9.38 0.46 1.08e-18 Parkinson's disease; CRC trans rs12517041 1.000 rs10054160 chr5:23297609 C/A ch.8.1293020R chr8:59333349 UBXN2B -0.55 -6.17 -0.32 2.05e-9 Calcium levels; CRC cis rs11741688 0.557 rs2004503 chr5:178337122 C/T cg20935368 chr5:178288625 ZNF354B 0.44 7.21 0.37 3.91e-12 Sleep duration; CRC cis rs7428 0.545 rs4832163 chr2:85541083 T/C cg24342717 chr2:85555507 TGOLN2 -0.72 -12.02 -0.55 7.94e-28 Ear protrusion; CRC cis rs17125944 0.505 rs10483618 chr14:53203590 T/C cg00686598 chr14:53173677 PSMC6 1.18 10.92 0.52 6.58e-24 Alzheimer's disease (late onset); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg21411534 chr10:93558674 TNKS2 0.47 6.59 0.34 1.78e-10 Response to antipsychotic treatment; CRC cis rs916888 0.821 rs199507 chr17:44858855 A/G cg15921436 chr17:44337874 NA -0.68 -7.81 -0.4 7.78e-14 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC trans rs4650994 0.507 rs12141152 chr1:178514165 C/T cg05059571 chr16:84539110 KIAA1609 -0.64 -8.87 -0.44 4.81e-17 HDL cholesterol levels;HDL cholesterol; CRC cis rs17376456 0.825 rs13161885 chr5:93071242 A/C cg21475434 chr5:93447410 FAM172A 0.68 6.55 0.34 2.28e-10 Diabetic retinopathy; CRC cis rs1552244 0.572 rs6783705 chr3:10164783 A/G cg13047869 chr3:10149882 C3orf24 0.54 6.49 0.34 3.1e-10 Alzheimer's disease; CRC cis rs561341 1.000 rs473356 chr17:30321762 G/C cg12193833 chr17:30244370 NA -0.76 -8.87 -0.44 4.62e-17 Hip circumference adjusted for BMI; CRC cis rs11098499 0.954 rs6848389 chr4:120402622 A/G cg24375607 chr4:120327624 NA 0.51 7.85 0.4 6.08e-14 Corneal astigmatism; CRC cis rs6062302 0.522 rs3761126 chr20:62252044 C/T cg06363034 chr20:62225388 GMEB2 -0.43 -6.49 -0.34 3.14e-10 Glioblastoma; CRC cis rs9311676 0.681 rs4681846 chr3:58332543 T/C cg06643156 chr3:58380774 PXK -0.44 -6.8 -0.35 4.99e-11 Systemic lupus erythematosus; CRC cis rs4862750 0.872 rs6553029 chr4:187876470 G/T cg22105103 chr4:187893119 NA -0.64 -11.7 -0.54 1.09e-26 Lobe attachment (rater-scored or self-reported); CRC cis rs709400 0.930 rs28513222 chr14:104028069 A/T cg12935359 chr14:103987150 CKB -0.38 -5.82 -0.31 1.4e-8 Body mass index; CRC cis rs853679 0.517 rs9368554 chr6:28082711 T/C cg03623178 chr6:28175578 NA 0.95 12.17 0.56 2.13e-28 Depression; CRC cis rs801193 0.935 rs2659899 chr7:66186721 A/G cg00343986 chr7:65444356 GUSB 0.48 7.11 0.36 7.45e-12 Aortic root size; CRC cis rs4285028 0.948 rs35415993 chr3:121669236 C/A cg20356878 chr3:121714668 ILDR1 -0.48 -6.92 -0.36 2.43e-11 Multiple sclerosis; CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg21354621 chr12:46384284 SFRS2IP -0.49 -5.98 -0.31 5.95e-9 Diisocyanate-induced asthma; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg11501976 chr4:186064568 SLC25A4 0.45 6.42 0.33 4.67e-10 Response to antipsychotic treatment; CRC cis rs796364 1.000 rs1704186 chr2:200769539 A/C cg23649088 chr2:200775458 C2orf69 0.56 6.15 0.32 2.25e-9 Schizophrenia; CRC cis rs2836950 0.520 rs11911087 chr21:40665192 G/A cg11644478 chr21:40555479 PSMG1 -0.46 -6.83 -0.35 4.02e-11 Menarche (age at onset); CRC cis rs6938 0.618 rs11638130 chr15:75183935 G/A cg05627522 chr15:75251581 NA 0.41 6.27 0.33 1.16e-9 Breast cancer; CRC cis rs7647973 0.961 rs11130186 chr3:49275828 A/G cg07690219 chr3:49449608 TCTA;RHOA -0.48 -5.66 -0.3 3.34e-8 Menarche (age at onset); CRC trans rs61931739 0.534 rs12372557 chr12:34363843 C/T cg26384229 chr12:38710491 ALG10B 0.67 8.73 0.43 1.3e-16 Morning vs. evening chronotype; CRC cis rs11214589 0.774 rs10891544 chr11:113256152 A/C cg14159747 chr11:113255604 NA -0.61 -12.57 -0.57 7.51e-30 Neuroticism; CRC cis rs3750965 0.959 rs3376 chr11:68856680 G/A cg06818126 chr11:68850279 TPCN2 -0.47 -6.57 -0.34 1.95e-10 Hair color; CRC trans rs459571 0.792 rs55923934 chr9:136888233 C/G cg09836344 chr4:1243392 C4orf42;CTBP1 -0.83 -11.8 -0.55 5e-27 Platelet distribution width; CRC cis rs10197940 0.624 rs17270233 chr2:152372420 A/G cg19508488 chr2:152266495 RIF1 0.59 8.1 0.41 1.06e-14 Lung cancer; CRC cis rs9916302 0.904 rs8065879 chr17:37515978 G/A cg15445000 chr17:37608096 MED1 -0.44 -9.91 -0.48 1.94e-20 Glomerular filtration rate (creatinine); CRC cis rs858239 0.899 rs28635122 chr7:23310181 C/T cg00469287 chr7:23338798 C7orf30 0.49 6.19 0.32 1.77e-9 Cerebrospinal fluid biomarker levels; CRC trans rs9858542 0.953 rs35169793 chr3:49423274 A/G cg21665057 chr3:196295764 WDR53;FBXO45 -0.64 -8.75 -0.43 1.1e-16 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs11212617 0.905 rs6589007 chr11:108040104 A/G cg14761454 chr11:108092087 ATM;NPAT 0.44 6.72 0.35 8.15e-11 Response to metformin in type 2 diabetes (glycemic); CRC cis rs172166 0.637 rs1071893 chr6:28167635 G/C cg12172441 chr6:28176163 NA 0.59 8.52 0.43 5.68e-16 Cardiac Troponin-T levels; CRC cis rs1862618 0.671 rs2591958 chr5:56239369 C/G cg18230493 chr5:56204884 C5orf35 0.59 8.86 0.44 5.12e-17 Initial pursuit acceleration; CRC cis rs6879260 1.000 rs7730585 chr5:179733440 T/C cg13944838 chr5:179740914 GFPT2 -0.66 -10.29 -0.49 1.01e-21 Height; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg10651637 chr15:45315642 SORD 0.43 6.55 0.34 2.22e-10 Liver disease severity in Alagille syndrome; CRC cis rs10791097 0.694 rs7106995 chr11:130758152 G/T cg12179176 chr11:130786555 SNX19 0.77 12.62 0.57 4.9e-30 Autism spectrum disorder or schizophrenia;Schizophrenia; CRC cis rs9921222 0.597 rs7193109 chr16:413523 T/G cg26944245 chr16:421049 TMEM8A;MRPL28 0.39 5.73 0.3 2.22e-8 Bone mineral density (spine);Bone mineral density; CRC cis rs7760949 0.963 rs1467729 chr6:13911167 C/T cg27413430 chr6:13925136 RNF182 -0.3 -5.62 -0.3 4.18e-8 Mean corpuscular hemoglobin concentration; CRC cis rs11148252 0.846 rs1056335 chr13:52989863 C/T cg02158880 chr13:53174818 NA 0.49 7.37 0.38 1.37e-12 Lewy body disease; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg04591119 chr6:111197245 AMD1 0.47 6.52 0.34 2.65e-10 Response to antipsychotic treatment; CRC cis rs6582630 0.502 rs11181210 chr12:38298069 G/A cg26384229 chr12:38710491 ALG10B 0.69 9.74 0.47 7.18e-20 Drug-induced liver injury (flucloxacillin); CRC cis rs40363 0.723 rs2736 chr16:3536872 G/A cg00484396 chr16:3507460 NAT15 -0.65 -6.48 -0.34 3.26e-10 Tuberculosis; CRC cis rs6582630 0.555 rs6582503 chr12:38557886 A/C cg26384229 chr12:38710491 ALG10B 0.7 9.41 0.46 9.09e-19 Drug-induced liver injury (flucloxacillin); CRC cis rs73200209 0.626 rs56178625 chr12:116578048 A/G cg01776926 chr12:116560359 MED13L -0.62 -7.14 -0.37 6.18e-12 Total body bone mineral density; CRC cis rs709400 1.000 rs3783404 chr14:104118498 A/G cg24130564 chr14:104152367 KLC1 -0.45 -6.77 -0.35 5.8e-11 Body mass index; CRC cis rs12477438 0.520 rs6741773 chr2:99738962 A/C cg26064155 chr2:99771622 LIPT1;TSGA10 0.89 16.23 0.67 6.36e-44 Chronic sinus infection; CRC cis rs2289583 0.642 rs7162941 chr15:75385622 C/T cg14664628 chr15:75095509 CSK 0.45 6.26 0.33 1.23e-9 Systemic lupus erythematosus; CRC cis rs9648716 1.000 rs10255130 chr7:140587633 C/T cg10747023 chr7:140774559 NA 0.45 5.9 0.31 9.21e-9 Type 2 diabetes; CRC cis rs11711311 0.955 rs7650764 chr3:113414439 A/G cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.45 -6.14 -0.32 2.44e-9 IgG glycosylation; CRC cis rs17376456 0.569 rs2045021 chr5:93224222 G/A cg25358565 chr5:93447407 FAM172A -0.7 -8.56 -0.43 4.37e-16 Diabetic retinopathy; CRC cis rs853679 0.517 rs1904841 chr6:28108085 C/T cg18032046 chr6:28092343 ZSCAN16 -0.5 -5.75 -0.3 2.07e-8 Depression; CRC cis rs4975709 0.569 rs2077269 chr5:1863506 C/T cg12288994 chr5:1860383 NA 0.39 6.89 0.35 2.89e-11 Cardiovascular disease risk factors; CRC cis rs3741404 0.791 rs11603192 chr11:63927695 A/G cg05016508 chr11:63871570 FLRT1;MACROD1 0.46 6.98 0.36 1.64e-11 Platelet count; CRC cis rs8060686 0.565 rs75735284 chr16:68126635 C/A cg26727032 chr16:67993705 SLC12A4 -0.55 -6.31 -0.33 9.17e-10 HDL cholesterol;Metabolic syndrome; CRC trans rs16846053 0.786 rs72877309 chr2:162587828 A/G cg14875682 chr5:52083620 ITGA1;PELO -0.75 -6.11 -0.32 2.78e-9 Blood osmolality (transformed sodium); CRC cis rs10504229 0.683 rs17194529 chr8:58105647 A/G cg20607798 chr8:58055168 NA 0.51 5.83 0.31 1.36e-8 Developmental language disorder (linguistic errors); CRC cis rs7927771 1.000 rs12363232 chr11:47623890 C/T cg18512352 chr11:47633146 NA -0.48 -9.51 -0.46 4.33e-19 Subjective well-being; CRC cis rs7953508 0.580 rs10859534 chr12:93975208 G/A cg18151635 chr12:93972918 NA -0.83 -11.23 -0.53 5.43e-25 Pubertal anthropometrics; CRC trans rs2243480 1.000 rs10950032 chr7:65738591 C/A cg10756647 chr7:56101905 PSPH -0.77 -7.87 -0.4 5.06e-14 Diabetic kidney disease; CRC cis rs282587 0.569 rs378432 chr13:113398048 A/C cg04656015 chr13:113407548 ATP11A 0.64 8.02 0.4 1.83e-14 Glycated hemoglobin levels; CRC cis rs6570726 0.846 rs397311 chr6:145806701 C/T cg13319975 chr6:146136371 FBXO30 0.4 6.16 0.32 2.17e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs6570726 1.000 rs404229 chr6:145868200 G/A cg05347473 chr6:146136440 FBXO30 0.4 6.18 0.32 1.89e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs3096299 0.503 rs9940093 chr16:89558705 G/A cg00750074 chr16:89608354 SPG7 -0.5 -7.53 -0.38 4.85e-13 Multiple myeloma (IgH translocation); CRC cis rs6570726 1.000 rs405622 chr6:145871897 G/T cg05347473 chr6:146136440 FBXO30 0.4 6.23 0.32 1.43e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs739401 0.595 rs6578304 chr11:2998279 A/G cg05729581 chr11:3078854 CARS 0.48 6.96 0.36 1.9e-11 Longevity; CRC cis rs2415984 0.500 rs12323609 chr14:46976023 C/G cg14871534 chr14:47121158 RPL10L -0.41 -5.93 -0.31 7.74e-9 Number of children ever born; CRC cis rs4730250 0.707 rs257381 chr7:106803963 T/C cg02696742 chr7:106810147 HBP1 -0.63 -7.06 -0.36 1.01e-11 Osteoarthritis; CRC cis rs17021463 0.902 rs11097413 chr4:95249286 C/T cg11021082 chr4:95130006 SMARCAD1 0.52 8.16 0.41 7.14e-15 Testicular germ cell tumor; CRC cis rs12760731 0.623 rs12023044 chr1:178407772 G/A cg00404053 chr1:178313656 RASAL2 0.75 9.35 0.46 1.4e-18 Obesity-related traits; CRC cis rs7487075 1.000 rs7487075 chr12:46828918 G/A cg22049899 chr12:47219821 SLC38A4 0.32 6.33 0.33 8.14e-10 Itch intensity from mosquito bite; CRC cis rs10504229 0.724 rs58715581 chr8:58134568 A/G cg21724239 chr8:58056113 NA 0.49 6.81 0.35 4.75e-11 Developmental language disorder (linguistic errors); CRC cis rs5750830 0.649 rs5757664 chr22:39821536 A/G cg11247378 chr22:39784982 NA -0.46 -8.71 -0.43 1.55e-16 Intelligence (multi-trait analysis); CRC cis rs3806843 0.966 rs12659129 chr5:140147248 T/C cg16607685 chr5:140181889 PCDHA2;PCDHA1;PCDHA3 -0.26 -5.91 -0.31 8.42e-9 Depressive symptoms (multi-trait analysis); CRC cis rs7786808 0.741 rs35059736 chr7:158224692 C/T cg09998033 chr7:158218633 PTPRN2 -0.64 -8.98 -0.44 2.17e-17 Obesity-related traits; CRC cis rs2050392 0.931 rs2265189 chr10:30689316 C/T cg18806716 chr10:30721971 MAP3K8 0.46 6.94 0.36 2.06e-11 Inflammatory bowel disease; CRC trans rs1864585 0.520 rs12155811 chr8:10673513 C/T cg26278703 chr11:58910052 FAM111A 0.56 6.63 0.34 1.42e-10 Neutrophil percentage of white cells;Lymphocyte percentage of white cells; CRC trans rs1814175 0.645 rs1722000 chr11:49917928 A/C cg11707556 chr5:10655725 ANKRD33B -0.52 -9.95 -0.48 1.49e-20 Height; CRC cis rs9329289 1.000 rs9329289 chr10:2542389 A/G cg15501526 chr10:2543763 NA 0.77 16.27 0.67 4.38e-44 Age-related hearing impairment; CRC cis rs769267 0.895 rs2965183 chr19:19545696 G/A cg01262667 chr19:19385393 TM6SF2 0.35 5.79 0.3 1.6e-8 Tonsillectomy; CRC cis rs4285028 0.948 rs35415993 chr3:121669236 C/A cg11130432 chr3:121712080 ILDR1 -0.51 -6.64 -0.34 1.28e-10 Multiple sclerosis; CRC cis rs7408868 0.831 rs7249115 chr19:15280765 A/G cg14696996 chr19:15285081 NOTCH3 0.54 5.99 0.31 5.41e-9 Pulse pressure; CRC cis rs8067545 0.611 rs2042046 chr17:20018841 A/G cg13482628 chr17:19912719 NA 0.43 6.92 0.36 2.33e-11 Schizophrenia; CRC cis rs2404602 1.000 rs2896954 chr15:76851692 C/A cg22467129 chr15:76604101 ETFA -0.42 -7.17 -0.37 5.06e-12 Blood metabolite levels; CRC cis rs1862618 0.525 rs2662016 chr5:56269047 A/G cg20203395 chr5:56204925 C5orf35 0.68 8.28 0.42 3.22e-15 Initial pursuit acceleration; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg12554051 chr12:665863 B4GALNT3 -0.39 -6.83 -0.35 4.08e-11 Liver disease severity in Alagille syndrome; CRC trans rs10842750 1.000 rs10842750 chr12:26690565 G/T cg14310730 chr9:100685193 C9orf156 0.52 6.02 0.31 4.57e-9 Kashin-Beck disease; CRC cis rs6951245 0.872 rs113119264 chr7:1080564 G/A cg03188948 chr7:1209495 NA 0.63 6.54 0.34 2.29e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC trans rs10983614 1.000 rs7867776 chr9:120072627 A/G cg10345131 chr15:91475918 UNC45A;HDDC3 0.44 6.09 0.32 3.09e-9 Survival in pancreatic cancer; CRC cis rs8067545 0.750 rs4925080 chr17:19991838 T/A cg13482628 chr17:19912719 NA 0.49 7.65 0.39 2.23e-13 Schizophrenia; CRC cis rs78456975 1.000 rs72778004 chr2:1571892 T/A cg12573674 chr2:1569213 NA -0.74 -7.89 -0.4 4.59e-14 Placebo response in major depressive disorder (% change in symptom score); CRC trans rs2303319 0.504 rs62187611 chr2:162431946 A/G cg00039960 chr17:7142925 PHF23 -0.73 -6.0 -0.31 5.26e-9 Cognitive function; CRC cis rs801193 0.569 rs2659907 chr7:66164032 G/A cg18876405 chr7:65276391 NA 0.51 8.24 0.41 4.19e-15 Aortic root size; CRC cis rs4731207 0.698 rs11978656 chr7:124449965 C/T cg23710748 chr7:124431027 NA 0.37 5.96 0.31 6.53e-9 Cutaneous malignant melanoma; CRC cis rs6988985 0.678 rs28659182 chr8:143999919 T/A cg10324643 chr8:143916377 GML 0.39 6.54 0.34 2.34e-10 Plasma androstenedione levels in resected early stage-receptor positive breast cancer; CRC cis rs1707322 1.000 rs6661500 chr1:46465662 T/C cg03146154 chr1:46216737 IPP 0.51 7.0 0.36 1.49e-11 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs9467773 0.596 rs2451751 chr6:26646714 T/C cg09904177 chr6:26538194 HMGN4 0.72 11.39 0.53 1.47e-25 Intelligence (multi-trait analysis); CRC cis rs7591163 1.000 rs940341 chr2:228724726 A/G cg08034379 chr2:228736324 WDR69 -0.51 -6.9 -0.36 2.65e-11 Blood pressure; CRC cis rs10504229 0.775 rs55734109 chr8:58162322 G/A cg05313129 chr8:58192883 C8orf71 -0.48 -5.91 -0.31 8.52e-9 Developmental language disorder (linguistic errors); CRC cis rs9916302 0.706 rs8075737 chr17:37727316 C/T cg20243544 chr17:37824526 PNMT -0.46 -5.77 -0.3 1.86e-8 Glomerular filtration rate (creatinine); CRC cis rs4332037 0.707 rs73046323 chr7:1882795 G/A cg13880726 chr7:1868755 MAD1L1 -0.43 -5.71 -0.3 2.54e-8 Bipolar disorder; CRC cis rs1707322 1.000 rs946524 chr1:46487560 A/G cg03146154 chr1:46216737 IPP -0.5 -6.97 -0.36 1.72e-11 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs9916302 0.851 rs11078904 chr17:37650569 G/A cg00129232 chr17:37814104 STARD3 -0.55 -8.16 -0.41 6.96e-15 Glomerular filtration rate (creatinine); CRC cis rs9837602 0.507 rs793453 chr3:99529095 A/C cg08350549 chr3:99591722 C3orf26;FILIP1L;MIR548G -0.4 -6.2 -0.32 1.69e-9 Breast cancer; CRC cis rs2282802 0.685 rs2116790 chr5:139654115 G/A cg26211634 chr5:139558579 C5orf32 0.4 6.74 0.35 7.01e-11 Intelligence (multi-trait analysis); CRC cis rs17767392 0.958 rs10135680 chr14:72030809 G/A cg13720639 chr14:72061746 SIPA1L1 0.56 6.88 0.35 3.04e-11 Mitral valve prolapse; CRC cis rs9858542 1.000 rs11130213 chr3:49712297 C/T cg03060546 chr3:49711283 APEH -0.53 -7.11 -0.37 7.16e-12 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg04682787 chr11:65339779 FAM89B 0.46 6.47 0.34 3.46e-10 Response to antipsychotic treatment; CRC cis rs5498 0.839 rs62130688 chr19:10409007 T/C cg10604476 chr19:10403908 ICAM5 0.3 5.66 0.3 3.3e-8 Lymphocyte counts;Soluble ICAM-1;Blood protein levels; CRC cis rs17023223 0.537 rs12092807 chr1:119750644 A/G cg05756136 chr1:119680316 WARS2 0.48 6.56 0.34 2.09e-10 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for BMI in active individuals; CRC cis rs514406 0.800 rs7548519 chr1:53294473 A/G cg25767906 chr1:53392781 SCP2 -0.41 -6.67 -0.35 1.08e-10 Monocyte count; CRC cis rs7474896 0.515 rs688608 chr10:38331624 G/A cg25427524 chr10:38739819 LOC399744 0.64 7.75 0.39 1.13e-13 Obesity (extreme); CRC trans rs11148252 0.595 rs9526974 chr13:53251040 C/G cg18335740 chr13:41363409 SLC25A15 0.76 13.75 0.6 2.69e-34 Lewy body disease; CRC cis rs4237845 0.636 rs11172371 chr12:58286188 C/T cg02175503 chr12:58329896 NA 0.51 5.88 0.31 1.02e-8 Intelligence (multi-trait analysis); CRC cis rs7394190 0.748 rs11000766 chr10:75512952 C/T cg07699608 chr10:75541558 CHCHD1 0.61 6.36 0.33 6.64e-10 Incident atrial fibrillation; CRC cis rs6912958 0.559 rs499373 chr6:88042062 A/T cg08069147 chr6:88032118 GJB7;C6orf162 0.75 12.12 0.56 3.32e-28 Monocyte percentage of white cells; CRC cis rs9814567 1.000 rs1880376 chr3:134270347 A/G cg06541857 chr3:134203789 ANAPC13;CEP63 0.39 5.74 0.3 2.15e-8 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs6860806 0.661 rs4705927 chr5:131578608 C/G cg22638593 chr5:131593259 PDLIM4 0.4 7.55 0.38 4.31e-13 Breast cancer; CRC cis rs8031584 0.541 rs2959037 chr15:31218164 T/C cg14829155 chr15:31115871 NA 0.36 5.85 0.31 1.18e-8 Huntington's disease progression; CRC cis rs7589728 0.514 rs78204719 chr2:88460747 G/C cg14558114 chr2:88469736 THNSL2 0.6 6.1 0.32 2.96e-9 Plasma clusterin levels; CRC cis rs2795502 0.564 rs72777187 chr10:43432224 C/T cg20628663 chr10:43360327 NA 0.56 6.77 0.35 5.97e-11 Blood protein levels; CRC cis rs7945718 1.000 rs12269900 chr11:12748518 G/A cg25843174 chr11:12811716 TEAD1 0.47 8.97 0.44 2.23e-17 Educational attainment (years of education); CRC cis rs875971 0.862 rs7798630 chr7:65771479 G/C cg18876405 chr7:65276391 NA -0.53 -8.56 -0.43 4.37e-16 Aortic root size; CRC trans rs6693295 0.729 rs10737782 chr1:246215358 C/T cg03680032 chr11:94965610 SESN3 0.49 6.12 0.32 2.68e-9 Migraine - clinic-based;Migraine with aura; CRC cis rs877282 0.700 rs816311 chr10:796490 C/A cg17470449 chr10:769945 NA 0.46 6.42 0.33 4.71e-10 Uric acid levels; CRC trans rs7395662 0.500 rs1605360 chr11:48685714 G/A cg00717180 chr2:96193071 NA -0.38 -6.27 -0.33 1.15e-9 HDL cholesterol; CRC trans rs66887589 0.967 rs3775842 chr4:120427732 G/A cg25214090 chr10:38739885 LOC399744 0.42 6.49 0.34 3.21e-10 Diastolic blood pressure; CRC cis rs8060686 0.641 rs73612208 chr16:68206844 G/A cg08314208 chr16:67682810 RLTPR -0.47 -5.69 -0.3 2.75e-8 HDL cholesterol;Metabolic syndrome; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg22819616 chr8:144952622 NA 0.35 5.98 0.31 5.96e-9 Liver disease severity in Alagille syndrome; CRC cis rs2380220 0.516 rs7748108 chr6:96008082 T/C cg04719120 chr6:96025338 MANEA 0.63 8.56 0.43 4.43e-16 Behavioural disinhibition (generation interaction); CRC cis rs992157 0.835 rs13005100 chr2:219151767 C/T cg04731861 chr2:219085781 ARPC2 0.34 6.94 0.36 2.13e-11 Colorectal cancer; CRC cis rs2346177 0.519 rs35509718 chr2:46696793 T/C cg26688816 chr2:46740690 ATP6V1E2 -0.62 -9.34 -0.46 1.5e-18 HDL cholesterol; CRC cis rs6662572 0.737 rs77017199 chr1:46532407 G/A cg03123370 chr1:45965343 CCDC163P;MMACHC 0.47 5.94 0.31 7.12e-9 Blood protein levels; CRC trans rs7200786 0.546 rs11643622 chr16:11225515 A/G cg24513522 chr17:77393929 HRNBP3 -0.33 -5.99 -0.31 5.42e-9 Multiple sclerosis;Systemic lupus erythematosus; CRC cis rs10504229 1.000 rs79561699 chr8:58170601 A/G cg05313129 chr8:58192883 C8orf71 -0.46 -7.06 -0.36 9.7e-12 Developmental language disorder (linguistic errors); CRC cis rs11764590 0.715 rs55810445 chr7:2103739 C/T cg23378565 chr7:2036160 MAD1L1 -0.42 -5.8 -0.3 1.52e-8 Neuroticism; CRC cis rs2019137 0.539 rs4849177 chr2:113982584 T/C cg21482265 chr2:113992762 PAX8;LOC440839;LOC654433 0.61 9.28 0.46 2.34e-18 Lymphocyte counts; CRC cis rs7772486 0.754 rs6921073 chr6:146144377 G/A cg13319975 chr6:146136371 FBXO30 -0.44 -6.53 -0.34 2.54e-10 Lobe attachment (rater-scored or self-reported); CRC cis rs2832191 0.791 rs7283853 chr21:30498515 G/A cg24692254 chr21:30365293 RNF160 -0.67 -11.18 -0.52 8.28e-25 Dental caries; CRC cis rs7208859 0.623 rs7223404 chr17:29107363 C/T cg13385521 chr17:29058706 SUZ12P 0.73 8.4 0.42 1.39e-15 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs7845219 0.544 rs10956932 chr8:95948202 C/T cg13393036 chr8:95962371 TP53INP1 0.36 5.75 0.3 2.02e-8 Type 2 diabetes; CRC cis rs644799 0.525 rs3016206 chr11:95536724 T/C cg25622487 chr11:95524042 FAM76B;CEP57 0.8 13.56 0.6 1.35e-33 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs703842 0.963 rs923829 chr12:58174306 T/C cg00677455 chr12:58241039 CTDSP2 0.67 9.41 0.46 8.94e-19 Multiple sclerosis; CRC cis rs7591163 1.000 rs4973380 chr2:228725402 T/A cg14329157 chr2:228736135 WDR69 -0.45 -6.24 -0.33 1.36e-9 Blood pressure; CRC cis rs554111 0.510 rs10916863 chr1:21120592 C/T cg02927042 chr1:21476669 EIF4G3 -0.38 -5.62 -0.3 3.97e-8 Facial morphology (factor 17, height of vermillion upper lip); CRC trans rs1945380 0.964 rs4315098 chr11:80389928 T/C cg00859112 chr14:99736559 BCL11B 0.44 6.0 0.31 5.16e-9 Diabetic kidney disease; CRC cis rs7149337 0.805 rs3007164 chr14:51646935 A/G cg03361068 chr14:51561562 TRIM9 0.28 5.94 0.31 7.26e-9 Cancer; CRC cis rs1728785 1.000 rs1170433 chr16:68606081 A/G cg02972257 chr16:68554789 NA -0.6 -7.52 -0.38 5.1e-13 Ulcerative colitis; CRC cis rs9818758 0.607 rs34343820 chr3:49309534 C/G cg07636037 chr3:49044803 WDR6 -0.72 -6.08 -0.32 3.38e-9 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; CRC cis rs4760636 0.648 rs12815462 chr12:48160252 G/A cg13326926 chr12:48153388 RAPGEF3 0.61 6.06 0.32 3.63e-9 Urate levels; CRC cis rs1153858 1.000 rs12591058 chr15:45640172 T/C cg10760299 chr15:45669010 GATM 0.5 7.97 0.4 2.72e-14 Homoarginine levels; CRC cis rs2346177 0.875 rs2166745 chr2:46646879 C/G cg26688816 chr2:46740690 ATP6V1E2 -0.53 -8.45 -0.42 9.41e-16 HDL cholesterol; CRC cis rs9747201 0.962 rs34016823 chr17:80095428 G/T cg14673194 chr17:80132900 CCDC57 0.49 6.35 0.33 7.03e-10 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs1552244 0.872 rs6792951 chr3:10119603 C/A cg08888203 chr3:10149979 C3orf24 0.7 9.9 0.48 2.22e-20 Alzheimer's disease; CRC cis rs8078723 0.714 rs12940405 chr17:38143768 C/T cg17344932 chr17:38183730 MED24;SNORD124 0.48 7.94 0.4 3.33e-14 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); CRC cis rs847577 0.677 rs951988 chr7:97762474 C/G cg24562669 chr7:97807699 LMTK2 -0.63 -11.76 -0.54 6.99e-27 Breast cancer; CRC cis rs7394190 0.748 rs4746146 chr10:75527197 C/T cg07699608 chr10:75541558 CHCHD1 0.6 6.34 0.33 7.42e-10 Incident atrial fibrillation; CRC cis rs11098499 0.866 rs12374244 chr4:120281972 A/T cg09307838 chr4:120376055 NA 0.68 10.53 0.5 1.51e-22 Corneal astigmatism; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg21951070 chr3:185826924 ETV5 0.38 6.32 0.33 8.31e-10 Liver disease severity in Alagille syndrome; CRC trans rs4130344 0.935 rs11725623 chr4:159732671 A/G cg13704678 chr3:10362667 SEC13 -0.44 -6.31 -0.33 8.83e-10 Intelligence (multi-trait analysis); CRC cis rs9611565 0.694 rs202616 chr22:41822221 C/G cg03806693 chr22:41940476 POLR3H 1.1 13.52 0.6 1.95e-33 Vitiligo; CRC cis rs13118159 0.550 rs28733902 chr4:1374789 A/G cg19318889 chr4:1322082 MAEA 0.68 9.96 0.48 1.37e-20 Longevity; CRC trans rs7647973 0.710 rs6797299 chr3:49609794 G/T cg21659725 chr3:3221576 CRBN -0.69 -7.14 -0.37 6.11e-12 Menarche (age at onset); CRC cis rs13082711 0.513 rs7612102 chr3:27372826 A/G cg02860705 chr3:27208620 NA -0.7 -9.16 -0.45 5.5e-18 Systolic blood pressure;Diastolic blood pressure;Blood pressure; CRC cis rs4654899 0.758 rs6693055 chr1:21421813 C/T cg02927042 chr1:21476669 EIF4G3 -0.41 -6.53 -0.34 2.57e-10 Superior frontal gyrus grey matter volume; CRC cis rs4588572 0.643 rs1019803 chr5:77739154 A/G cg11547950 chr5:77652471 NA -0.49 -6.56 -0.34 2.11e-10 Triglycerides; CRC cis rs6424115 0.965 rs2502979 chr1:24149315 C/A cg15997130 chr1:24165203 NA 0.75 11.72 0.54 9.87e-27 Immature fraction of reticulocytes; CRC cis rs10504229 0.683 rs67492041 chr8:58140077 G/A cg02725872 chr8:58115012 NA -0.64 -11.55 -0.54 3.85e-26 Developmental language disorder (linguistic errors); CRC cis rs2456568 0.900 rs2511376 chr11:93670388 C/T cg26875233 chr11:93583750 C11orf90 -0.33 -6.46 -0.34 3.85e-10 Response to serotonin reuptake inhibitors in major depressive disorder; CRC cis rs2070488 1.000 rs7373816 chr3:38490443 C/A cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.91 16.81 0.68 3.37e-46 Electrocardiographic conduction measures; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg12694820 chr6:41041189 NFYA;C6orf130 0.47 6.01 0.31 4.88e-9 Thyroid stimulating hormone; CRC cis rs2735413 0.918 rs4887932 chr16:78078350 C/A cg04733911 chr16:78082701 NA -0.45 -7.37 -0.38 1.38e-12 Systolic blood pressure (alcohol consumption interaction); CRC trans rs2235573 0.594 rs4821730 chr22:38441587 A/G cg19894588 chr14:64061835 NA 0.42 6.02 0.31 4.58e-9 Glioblastoma;Glioma; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg02608292 chr19:55897501 RPL28 0.51 6.56 0.34 2.13e-10 Thyroid stimulating hormone; CRC cis rs9399135 0.967 rs4376365 chr6:135307740 T/C cg22676075 chr6:135203613 NA 0.43 6.67 0.35 1.05e-10 Red blood cell count; CRC cis rs7119 0.931 rs7176875 chr15:77832675 A/G cg10437265 chr15:77819839 NA -0.54 -9.36 -0.46 1.31e-18 Type 2 diabetes; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg24180569 chr12:6309517 CD9 0.42 6.27 0.33 1.11e-9 Intelligence (multi-trait analysis); CRC cis rs2456568 0.548 rs10466334 chr11:93663512 A/G cg26875233 chr11:93583750 C11orf90 -0.36 -6.9 -0.36 2.67e-11 Response to serotonin reuptake inhibitors in major depressive disorder; CRC cis rs2243480 1.000 rs73142162 chr7:65374296 A/T cg12463550 chr7:65579703 CRCP 0.69 6.43 0.33 4.37e-10 Diabetic kidney disease; CRC cis rs9322193 0.923 rs9688350 chr6:150052113 A/T cg13206674 chr6:150067644 NUP43 0.66 9.52 0.46 3.79e-19 Lung cancer; CRC cis rs9388451 0.626 rs9385383 chr6:126086290 G/T cg05901451 chr6:126070800 HEY2 -0.51 -8.48 -0.42 7.58e-16 Brugada syndrome; CRC cis rs6938 0.534 rs11636892 chr15:75266049 G/C cg18612461 chr15:75251733 NA 0.48 7.25 0.37 2.91e-12 Breast cancer; CRC cis rs9911578 1.000 rs2567911 chr17:56734977 A/G cg05425664 chr17:57184151 TRIM37 -0.5 -7.94 -0.4 3.16e-14 Intelligence (multi-trait analysis); CRC cis rs11098499 0.865 rs10213221 chr4:120255926 G/A cg24375607 chr4:120327624 NA 0.46 7.28 0.37 2.54e-12 Corneal astigmatism; CRC cis rs780096 0.526 rs704791 chr2:27657167 T/C cg27432699 chr2:27873401 GPN1 -0.51 -7.82 -0.4 7.11e-14 Total body bone mineral density; CRC cis rs3809863 0.646 rs9899121 chr17:45395144 C/T cg25173405 chr17:45401733 C17orf57 -0.65 -10.33 -0.49 7.7e-22 Glaucoma (primary open-angle); CRC cis rs28386778 0.799 rs2584612 chr17:61932204 A/G cg22520471 chr17:61851767 DDX42;CCDC47 0.73 11.34 0.53 2.15e-25 Prudent dietary pattern; CRC cis rs4555082 0.957 rs2816627 chr14:105736109 A/G cg06808227 chr14:105710500 BRF1 -0.62 -9.5 -0.46 4.6e-19 Mean platelet volume;Platelet distribution width; CRC cis rs2425143 0.512 rs2425126 chr20:34331730 T/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.48 -6.54 -0.34 2.38e-10 Blood protein levels; CRC cis rs897984 0.542 rs7199949 chr16:31096164 G/C cg02466173 chr16:30829666 NA -0.59 -8.97 -0.44 2.32e-17 Dementia with Lewy bodies; CRC cis rs9648716 0.873 rs10251793 chr7:140587169 C/T cg10747023 chr7:140774559 NA 0.44 5.88 0.31 9.82e-9 Type 2 diabetes; CRC trans rs3733585 0.699 rs4515163 chr4:9959603 C/T cg26043149 chr18:55253948 FECH -0.5 -7.62 -0.39 2.81e-13 Cleft plate (environmental tobacco smoke interaction); CRC cis rs2404602 0.735 rs2461871 chr15:76822418 C/G cg03037974 chr15:76606532 NA -0.41 -6.14 -0.32 2.36e-9 Blood metabolite levels; CRC cis rs651907 0.557 rs3094295 chr3:101401995 T/C cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.62 8.31 0.42 2.51e-15 Colorectal cancer; CRC cis rs10504229 0.610 rs6999661 chr8:58127391 C/G cg24829409 chr8:58192753 C8orf71 -0.55 -8.03 -0.4 1.71e-14 Developmental language disorder (linguistic errors); CRC cis rs6942756 1.000 rs2141075 chr7:128877305 C/T cg02491457 chr7:128862824 NA 0.73 10.11 0.49 4.07e-21 White matter hyperintensity burden; CRC cis rs561341 0.941 rs4795664 chr17:30233467 C/T cg12193833 chr17:30244370 NA -0.67 -8.19 -0.41 5.7e-15 Hip circumference adjusted for BMI; CRC cis rs2252521 0.583 rs317763 chr7:29082303 A/G cg11728747 chr7:29037910 CPVL -0.52 -7.22 -0.37 3.69e-12 Cognitive performance; CRC cis rs1003719 0.788 rs2040341 chr21:38489753 T/C cg10648535 chr21:38446584 PIGP;TTC3 0.53 7.49 0.38 6.44e-13 Eye color traits; CRC cis rs12347191 0.500 rs925485 chr9:100619561 G/C cg13688889 chr9:100608707 NA -0.48 -6.09 -0.32 3.2e-9 Orofacial clefts; CRC cis rs6496667 0.865 rs62019349 chr15:90921658 C/T cg04176472 chr15:90893244 GABARAPL3 0.6 7.88 0.4 4.77e-14 Rheumatoid arthritis; CRC cis rs977987 0.806 rs4888390 chr16:75400320 G/A cg03315344 chr16:75512273 CHST6 0.54 9.11 0.45 8.15e-18 Dupuytren's disease; CRC trans rs2243480 0.901 rs778693 chr7:65872345 T/G cg10756647 chr7:56101905 PSPH 0.78 8.01 0.4 1.97e-14 Diabetic kidney disease; CRC cis rs2242116 0.734 rs4683294 chr3:46979013 C/G cg02527881 chr3:46936655 PTH1R 0.46 8.33 0.42 2.2e-15 Birth weight; CRC cis rs7208859 0.623 rs73271872 chr17:29152228 C/G cg01831904 chr17:28903510 LRRC37B2 -0.61 -6.43 -0.33 4.58e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs4713118 0.869 rs2056925 chr6:27690905 A/G cg03623178 chr6:28175578 NA 0.66 9.07 0.45 1.07e-17 Parkinson's disease; CRC cis rs847577 0.748 rs13221897 chr7:97719699 G/A cg00277769 chr7:97922759 BAIAP2L1 -0.4 -6.78 -0.35 5.43e-11 Breast cancer; CRC trans rs9914544 0.505 rs4924774 chr17:18794920 A/C cg21372672 chr17:16614065 CCDC144A -0.38 -6.09 -0.32 3.09e-9 Educational attainment (years of education); CRC cis rs801193 0.967 rs34356500 chr7:66236607 G/T cg11764359 chr7:65958608 NA 0.51 7.95 0.4 3.02e-14 Aortic root size; CRC cis rs875971 0.862 rs1875057 chr7:65731855 A/G cg12463550 chr7:65579703 CRCP -0.5 -6.72 -0.35 8.01e-11 Aortic root size; CRC cis rs10791323 0.604 rs2723607 chr11:133711018 C/G cg06766960 chr11:133703094 NA -0.35 -5.75 -0.3 2.04e-8 Childhood ear infection; CRC cis rs2836974 0.831 rs11911149 chr21:40528375 C/T cg11644478 chr21:40555479 PSMG1 0.82 13.53 0.6 1.81e-33 Cognitive function; CRC trans rs6472235 0.749 rs62506641 chr8:66903691 C/T cg07884673 chr3:53033167 SFMBT1 -0.44 -6.06 -0.32 3.78e-9 Myopia (pathological);Plateletcrit; CRC cis rs10504229 0.639 rs72650811 chr8:58115661 G/A cg22535103 chr8:58192502 C8orf71 -0.7 -9.34 -0.46 1.47e-18 Developmental language disorder (linguistic errors); CRC cis rs4713118 0.869 rs9461401 chr6:27703291 G/A cg15845792 chr6:28175446 NA 0.65 9.11 0.45 7.98e-18 Parkinson's disease; CRC cis rs597539 0.652 rs627731 chr11:68698663 A/C cg04772025 chr11:68637568 NA 0.48 7.29 0.37 2.3e-12 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs12580194 0.593 rs61556775 chr12:55745640 A/C cg19537932 chr12:55886519 OR6C68 -0.72 -9.1 -0.45 9.11e-18 Cancer; CRC cis rs9733 0.596 rs72702557 chr1:150680130 A/G cg17724175 chr1:150552817 MCL1 0.57 9.12 0.45 7.76e-18 Tonsillectomy; CRC cis rs7666738 0.830 rs4472144 chr4:98956494 G/A cg17366294 chr4:99064904 C4orf37 0.43 7.22 0.37 3.66e-12 Colonoscopy-negative controls vs population controls; CRC trans rs13069244 1.000 rs13069244 chr3:180441172 G/A cg07959070 chr22:50026188 C22orf34 0.69 6.23 0.32 1.42e-9 Body mass index (joint analysis main effects and smoking interaction);BMI in non-smokers;BMI in smokers;BMI (adjusted for smoking behaviour); CRC cis rs977987 0.931 rs1834013 chr16:75496163 G/T cg03315344 chr16:75512273 CHST6 0.56 9.58 0.47 2.47e-19 Dupuytren's disease; CRC cis rs6502050 0.799 rs7502524 chr17:80107261 C/T cg19223190 chr17:80058835 NA 0.4 6.36 0.33 6.88e-10 Life satisfaction; CRC cis rs769267 0.965 rs12460764 chr19:19431963 G/T cg02546618 chr19:19431379 KIAA0892;SF4 -0.47 -6.65 -0.34 1.24e-10 Tonsillectomy; CRC cis rs9916302 0.752 rs9901219 chr17:37558369 T/G cg20243544 chr17:37824526 PNMT -0.43 -5.66 -0.3 3.28e-8 Glomerular filtration rate (creatinine); CRC cis rs870825 0.616 rs57271221 chr4:185627198 C/T cg04058563 chr4:185651563 MLF1IP 0.72 8.13 0.41 8.86e-15 Blood protein levels; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg20018225 chr2:85555517 TGOLN2 0.42 6.0 0.31 5.35e-9 Response to antipsychotic treatment; CRC cis rs12802244 1 rs12802244 chr11:47932666 G/A cg05585544 chr11:47624801 NA -0.58 -9.88 -0.48 2.4e-20 Neuroticism; CRC cis rs6088813 0.961 rs6060373 chr20:33914208 C/T cg04508476 chr20:34239394 CPNE1;RBM12 0.37 6.18 0.32 1.86e-9 Height; CRC cis rs823143 0.570 rs823082 chr1:205786935 C/T cg26354017 chr1:205819088 PM20D1 -0.64 -10.11 -0.49 4.22e-21 Monocyte percentage of white cells; CRC cis rs9368481 0.554 rs2754603 chr6:26965139 T/C cg12292205 chr6:26970375 C6orf41 -0.73 -11.84 -0.55 3.64e-27 Autism spectrum disorder or schizophrenia; CRC cis rs11809207 0.574 rs2783631 chr1:26504756 C/T cg00147160 chr1:26503991 CNKSR1 0.31 6.5 0.34 3.04e-10 Height; CRC cis rs720844 0.628 rs13003132 chr2:149295930 C/T cg09247360 chr2:149335327 NA -0.56 -5.83 -0.31 1.32e-8 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs8180040 0.764 rs13084117 chr3:47183239 C/A cg27129171 chr3:47204927 SETD2 0.68 11.12 0.52 1.36e-24 Colorectal cancer; CRC cis rs4743820 0.651 rs10820838 chr9:93930913 G/A cg14446406 chr9:93919335 NA -0.75 -13.54 -0.6 1.69e-33 Ulcerative colitis;Inflammatory bowel disease; CRC cis rs5769765 0.862 rs9616385 chr22:50313124 C/T cg02269571 chr22:50332266 NA -0.61 -7.92 -0.4 3.64e-14 Schizophrenia; CRC cis rs758324 0.947 rs13170693 chr5:131187826 T/C cg06307176 chr5:131281290 NA 0.42 6.14 0.32 2.32e-9 Alzheimer's disease in APOE e4- carriers; CRC trans rs12478296 1.000 rs4973685 chr2:243019089 A/C cg06834434 chr14:75079333 LTBP2 0.52 6.06 0.32 3.72e-9 Obesity-related traits; CRC cis rs2898681 0.519 rs3811781 chr4:53729166 T/G cg00338735 chr4:53728038 RASL11B 0.46 6.27 0.33 1.12e-9 Optic nerve measurement (cup area); CRC cis rs853679 0.517 rs9368554 chr6:28082711 T/C cg06470822 chr6:28175283 NA 1.0 13.06 0.58 1.06e-31 Depression; CRC cis rs6502050 0.769 rs8079122 chr17:80120427 G/T cg13198984 chr17:80129470 CCDC57 0.47 8.27 0.41 3.34e-15 Life satisfaction; CRC cis rs28386778 0.897 rs2727328 chr17:61923564 G/A cg06601766 chr17:61851465 DDX42;CCDC47 0.42 5.8 0.3 1.53e-8 Prudent dietary pattern; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg18935937 chr14:105293067 NA 0.5 6.56 0.34 2.05e-10 Thyroid stimulating hormone; CRC cis rs669446 0.533 rs11210913 chr1:44222597 G/A cg12908607 chr1:44402522 ARTN -0.33 -5.68 -0.3 3.03e-8 Amyotrophic lateral sclerosis (age of onset); CRC cis rs6840360 0.615 rs7669761 chr4:152609304 G/A cg09659197 chr4:152720779 NA 0.4 7.82 0.4 7.07e-14 Intelligence (multi-trait analysis); CRC cis rs270601 0.770 rs10463891 chr5:131597392 C/T cg11843238 chr5:131593191 PDLIM4 -0.52 -9.92 -0.48 1.9e-20 Acylcarnitine levels; CRC cis rs9925964 0.591 rs11649653 chr16:30918487 C/G cg02466173 chr16:30829666 NA 0.4 5.65 0.3 3.43e-8 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC trans rs2898290 0.540 rs12677146 chr8:11450737 C/G cg06636001 chr8:8085503 FLJ10661 -0.51 -7.2 -0.37 3.99e-12 Systolic blood pressure; CRC cis rs9394438 0.628 rs2153947 chr6:37544930 A/G cg00985040 chr6:37553208 NA -0.42 -6.99 -0.36 1.56e-11 IgG glycosylation; CRC cis rs9388451 0.657 rs4895799 chr6:126052729 C/T cg05901451 chr6:126070800 HEY2 -0.53 -8.8 -0.44 8.05e-17 Brugada syndrome; CRC cis rs72615157 0.634 rs79986079 chr7:99802044 C/T cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.57 6.78 0.35 5.45e-11 Lung function (FEV1/FVC); CRC cis rs13108904 0.521 rs4974609 chr4:1356924 A/C cg16405210 chr4:1374714 KIAA1530 0.44 6.35 0.33 7.09e-10 Obesity-related traits; CRC cis rs910316 1.000 rs12589815 chr14:75544101 C/T cg03030879 chr14:75389066 RPS6KL1 -0.44 -6.84 -0.35 3.96e-11 Height; CRC trans rs1499614 1.000 rs2659913 chr7:66157336 T/A cg10756647 chr7:56101905 PSPH 0.77 8.1 0.41 1.09e-14 Gout; CRC trans rs875971 0.660 rs2191268 chr7:66110224 C/T cg06529477 chr17:56709497 TEX14 -0.41 -6.56 -0.34 2.13e-10 Aortic root size; CRC cis rs3996993 0.809 rs10948722 chr6:52663813 A/G cg20803780 chr6:52668592 GSTA1 0.37 6.56 0.34 2.11e-10 Hemoglobin concentration; CRC cis rs798554 1.000 rs798545 chr7:2762386 C/T cg05055821 chr7:2758924 NA -0.36 -5.76 -0.3 1.98e-8 Height; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg18730023 chr12:44199730 TWF1 0.45 6.21 0.32 1.63e-9 Response to antipsychotic treatment; CRC cis rs6951245 0.748 rs79658522 chr7:1095877 A/G cg04025307 chr7:1156635 C7orf50 0.63 6.74 0.35 7.02e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs3540 0.597 rs1978150 chr15:91037041 A/G cg22089800 chr15:90895588 ZNF774 -0.56 -9.19 -0.45 4.52e-18 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; CRC cis rs734999 0.588 rs4648562 chr1:2535613 C/A cg18854424 chr1:2615690 NA 0.4 7.74 0.39 1.22e-13 Ulcerative colitis; CRC cis rs875971 0.545 rs11766183 chr7:65839160 G/C cg05627663 chr7:65219948 SNORA22;CCT6P1 0.62 7.92 0.4 3.58e-14 Aortic root size; CRC cis rs5750830 0.595 rs4821892 chr22:39795683 G/C cg24399712 chr22:39784796 NA -0.49 -9.51 -0.46 4.05e-19 Intelligence (multi-trait analysis); CRC cis rs13108904 0.967 rs4642180 chr4:1278914 T/C cg05665937 chr4:1216051 CTBP1 0.4 5.88 0.31 9.81e-9 Obesity-related traits; CRC cis rs7731657 0.537 rs10073197 chr5:130373090 C/T cg08523029 chr5:130500466 HINT1 -0.47 -6.06 -0.32 3.68e-9 Fasting plasma glucose; CRC trans rs12618769 0.652 rs3754872 chr2:99223925 A/T cg08397747 chr2:29038986 SPDYA 0.36 5.96 0.31 6.42e-9 Bipolar disorder; CRC cis rs9916302 0.904 rs8079303 chr17:37530755 G/C cg03013999 chr17:37608204 MED1 -0.47 -7.4 -0.38 1.14e-12 Glomerular filtration rate (creatinine); CRC cis rs11148252 0.811 rs9535895 chr13:52765847 G/A cg02158880 chr13:53174818 NA 0.44 6.65 0.34 1.22e-10 Lewy body disease; CRC cis rs1552244 1.000 rs12152512 chr3:10143770 C/T cg02579736 chr3:10068473 FANCD2;CIDECP 0.92 12.51 0.57 1.19e-29 Alzheimer's disease; CRC cis rs7617773 0.851 rs13068288 chr3:48331751 A/T cg11946769 chr3:48343235 NME6 0.64 8.59 0.43 3.47e-16 Coronary artery disease; CRC cis rs4234798 0.933 rs10020957 chr4:7222436 C/T cg18431297 chr4:7219810 SORCS2 -0.56 -10.49 -0.5 2.2e-22 Insulin-like growth factors; CRC cis rs11711311 1.000 rs9851731 chr3:113502651 A/G cg06805542 chr3:113465803 ATP6V1A;NAA50 0.51 7.04 0.36 1.12e-11 IgG glycosylation; CRC cis rs6725806 1.000 rs6725806 chr2:103216172 T/G cg00507830 chr2:103233733 NA 0.47 6.34 0.33 7.73e-10 Blood protein levels; CRC cis rs798766 1.000 rs798741 chr4:1712413 A/G cg25714306 chr4:1656736 FAM53A -0.31 -5.67 -0.3 3.16e-8 Bladder cancer;Urinary bladder cancer; CRC cis rs10191773 0.589 rs72831636 chr2:112948248 G/A cg04979063 chr2:113191202 RGPD5;RGPD8 0.65 5.74 0.3 2.15e-8 Yeast infection; CRC cis rs3749237 0.595 rs12489092 chr3:49550914 G/C cg03060546 chr3:49711283 APEH 0.61 10.29 0.49 1.05e-21 Resting heart rate; CRC cis rs847577 0.722 rs7790736 chr7:97713039 G/A cg21770322 chr7:97807741 LMTK2 0.82 18.06 0.71 3.69e-51 Breast cancer; CRC cis rs9469578 0.710 rs77213792 chr6:33713952 C/G cg18708504 chr6:33715942 IP6K3 0.66 7.56 0.38 4e-13 Phosphorus levels; CRC cis rs4604732 0.588 rs9943231 chr1:247629829 C/T cg12758973 chr1:247694275 LOC148824;OR2C3 0.38 5.75 0.3 2.03e-8 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CRC cis rs12042938 0.622 rs61707606 chr1:231813446 C/T cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX 0.42 5.65 0.3 3.49e-8 Neuranatomic and neurocognitive phenotypes; CRC cis rs4604732 0.631 rs10925044 chr1:247627071 A/G cg02104434 chr1:247694406 LOC148824;OR2C3 0.6 8.82 0.44 6.67e-17 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CRC cis rs6061231 0.798 rs2427308 chr20:60969451 C/T cg22601191 chr20:60968625 CABLES2 0.55 9.02 0.45 1.56e-17 Colorectal cancer; CRC cis rs6662572 0.703 rs4420029 chr1:46425500 G/A cg08644498 chr1:46502608 NA -0.41 -6.8 -0.35 4.88e-11 Blood protein levels; CRC cis rs6460942 1.000 rs7796485 chr7:12405676 G/A cg06484146 chr7:12443880 VWDE -0.74 -7.7 -0.39 1.56e-13 Coronary artery disease; CRC cis rs13256369 0.951 rs13260947 chr8:8565883 A/G cg18904891 chr8:8559673 CLDN23 0.55 7.42 0.38 9.97e-13 Obesity-related traits; CRC cis rs7552404 0.556 rs12124417 chr1:76353294 T/C cg03433033 chr1:76189801 ACADM 0.44 5.87 0.31 1.08e-8 Blood metabolite levels;Acylcarnitine levels; CRC cis rs4808199 0.947 rs10404728 chr19:19595014 C/T cg03709012 chr19:19516395 GATAD2A 1.01 12.11 0.56 3.6e-28 Nonalcoholic fatty liver disease; CRC cis rs752010 0.619 rs10736421 chr1:42106230 G/A cg06885757 chr1:42089581 HIVEP3 0.45 7.31 0.37 2.08e-12 Lupus nephritis in systemic lupus erythematosus; CRC cis rs11098499 0.754 rs7672372 chr4:120248406 A/G cg09307838 chr4:120376055 NA 0.62 9.65 0.47 1.46e-19 Corneal astigmatism; CRC cis rs1005277 0.579 rs2505196 chr10:38393563 G/A cg17219203 chr10:38645113 HSD17B7P2 -0.41 -5.76 -0.3 1.9e-8 Extrinsic epigenetic age acceleration; CRC cis rs798554 0.634 rs6978692 chr7:2857411 C/T cg17321639 chr7:2759063 NA -0.38 -5.86 -0.31 1.1e-8 Height; CRC cis rs1003719 0.788 rs4411798 chr21:38453183 A/G cg10648535 chr21:38446584 PIGP;TTC3 0.49 6.96 0.36 1.8e-11 Eye color traits; CRC cis rs9611565 0.625 rs73178625 chr22:41928320 G/C cg06634786 chr22:41940651 POLR3H -0.64 -7.53 -0.38 4.81e-13 Vitiligo; CRC cis rs67311347 1.000 rs56303661 chr3:40520778 C/G cg09455208 chr3:40491958 NA 0.51 9.82 0.48 3.86e-20 Renal cell carcinoma; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg03939875 chr1:46016565 AKR1A1 0.42 6.29 0.33 1e-9 Response to antipsychotic treatment; CRC cis rs6540559 0.673 rs926346 chr1:209962204 A/T cg25204440 chr1:209979598 IRF6 0.48 5.75 0.3 2.01e-8 Cleft lip with or without cleft palate; CRC cis rs4727963 0.846 rs12670195 chr7:122712925 T/G cg03640110 chr7:122635026 TAS2R16 0.33 5.86 0.31 1.15e-8 Adverse response to chemotherapy (neutropenia/leucopenia) (docetaxel); CRC trans rs57221529 0.766 rs12518859 chr5:587432 C/T cg11887960 chr12:57824829 NA 0.63 6.79 0.35 5.32e-11 Lung disease severity in cystic fibrosis; CRC cis rs10946940 0.864 rs13201411 chr6:27498217 G/C cg02683197 chr6:28174875 NA -0.55 -7.49 -0.38 6.34e-13 Systemic lupus erythematosus; CRC cis rs116095464 0.510 rs7723883 chr5:270798 T/C cg22857025 chr5:266934 NA -1.18 -16.27 -0.67 4.43e-44 Breast cancer; CRC cis rs10206020 0.921 rs11884956 chr2:1566426 A/G cg12573674 chr2:1569213 NA -0.81 -10.76 -0.51 2.42e-23 IgG glycosylation; CRC cis rs7666738 0.783 rs10028584 chr4:98962404 C/T cg17366294 chr4:99064904 C4orf37 0.44 7.31 0.37 2.03e-12 Colonoscopy-negative controls vs population controls; CRC cis rs6496044 0.568 rs7166642 chr15:86061271 A/G cg17133734 chr15:86042851 AKAP13 0.43 7.03 0.36 1.22e-11 Interstitial lung disease; CRC cis rs4566357 0.615 rs3769643 chr2:227917270 T/C cg11843606 chr2:227700838 RHBDD1 -0.44 -6.85 -0.35 3.65e-11 Coronary artery disease; CRC cis rs2179367 0.553 rs7762222 chr6:149765982 G/A cg11245181 chr6:149772854 ZC3H12D -0.4 -5.63 -0.3 3.91e-8 Dupuytren's disease; CRC cis rs4713118 0.869 rs6901520 chr6:27714575 G/T cg08798685 chr6:27730294 NA -0.43 -6.3 -0.33 9.81e-10 Parkinson's disease; CRC cis rs1401999 0.659 rs7622660 chr3:183753337 C/T cg01324343 chr3:183735012 ABCC5 0.73 12.0 0.55 9.35e-28 Anterior chamber depth; CRC cis rs7605827 0.930 rs13033762 chr2:15592295 T/C cg19274914 chr2:15703543 NA 0.38 5.76 0.3 1.92e-8 Educational attainment (years of education); CRC cis rs514406 0.861 rs11206026 chr1:53281708 G/A cg27535305 chr1:53392650 SCP2 -0.37 -6.59 -0.34 1.77e-10 Monocyte count; CRC cis rs9943465 0.688 rs318929 chr10:132071772 T/C cg12765123 chr10:132100019 NA 0.57 6.07 0.32 3.48e-9 Epstein-Barr virus copy number in lymphoblastoid cell lines; CRC cis rs873946 0.586 rs12770021 chr10:134562021 G/A cg26818010 chr10:134567672 INPP5A -0.67 -8.52 -0.43 5.74e-16 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CRC cis rs1475911 0.656 rs9980065 chr21:43528072 G/A cg24372256 chr21:43528868 UMODL1;C21orf128 -0.71 -9.28 -0.46 2.35e-18 IgG glycosylation; CRC cis rs10131894 0.611 rs174994 chr14:75434102 A/G cg03030879 chr14:75389066 RPS6KL1 0.41 6.35 0.33 7.25e-10 Coronary artery disease; CRC cis rs17376456 0.932 rs3940842 chr5:93534858 C/A cg21475434 chr5:93447410 FAM172A 0.74 6.87 0.35 3.27e-11 Diabetic retinopathy; CRC trans rs10242455 0.702 rs28753399 chr7:98997259 C/T cg09045935 chr12:6379348 NA 1.0 7.62 0.39 2.79e-13 Blood metabolite levels; CRC cis rs13108904 0.539 rs13141169 chr4:1340353 C/T cg21620606 chr4:1342894 KIAA1530 0.5 7.9 0.4 4.2e-14 Obesity-related traits; CRC cis rs6951245 0.935 rs76525951 chr7:1096013 C/T cg21664854 chr7:1097933 C7orf50;GPR146 0.78 8.81 0.44 7.57e-17 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs7044106 0.762 rs7024046 chr9:123419178 G/A cg09586646 chr9:123605570 PSMD5;LOC253039 0.62 8.82 0.44 7.03e-17 Hip circumference adjusted for BMI; CRC cis rs2153535 0.580 rs1335641 chr6:8487860 G/T cg21535247 chr6:8435926 SLC35B3 0.5 7.51 0.38 5.54e-13 Motion sickness; CRC cis rs12188164 0.931 rs115554641 chr5:443236 C/G cg16322479 chr5:444228 EXOC3;C5orf55 0.5 8.08 0.41 1.27e-14 Cystic fibrosis severity; CRC cis rs67478160 0.625 rs7141473 chr14:104316055 A/C cg01849466 chr14:104193079 ZFYVE21 0.46 8.02 0.4 1.89e-14 Schizophrenia; CRC cis rs2204008 0.628 rs10876106 chr12:37990767 A/G cg26384229 chr12:38710491 ALG10B 0.67 9.43 0.46 7.83e-19 Bladder cancer; CRC cis rs5769765 0.825 rs7511620 chr22:50307932 T/C cg04121214 chr22:50244548 NA 0.4 5.76 0.3 1.9e-8 Schizophrenia; CRC cis rs35000415 0.938 rs34725944 chr7:128641653 T/C cg19972273 chr7:128594194 NA 0.68 6.31 0.33 8.75e-10 Systemic lupus erythematosus; CRC cis rs11098499 0.955 rs4145951 chr4:120155817 A/G cg24375607 chr4:120327624 NA 0.44 6.86 0.35 3.46e-11 Corneal astigmatism; CRC cis rs4974559 0.739 rs3817604 chr4:1291337 C/T cg02980000 chr4:1222292 CTBP1 0.75 8.14 0.41 8.26e-15 Systolic blood pressure; CRC cis rs977987 0.835 rs3863445 chr16:75371744 C/G cg03315344 chr16:75512273 CHST6 0.52 8.65 0.43 2.38e-16 Dupuytren's disease; CRC trans rs3914167 0.881 rs3849759 chr5:39406098 C/T cg21800284 chr12:115107215 NA 0.43 6.02 0.31 4.71e-9 Systemic lupus erythematosus; CRC cis rs12760731 0.669 rs10798609 chr1:178431648 C/T cg00404053 chr1:178313656 RASAL2 0.85 10.04 0.48 7.24e-21 Obesity-related traits; CRC cis rs73206853 0.841 rs73191824 chr12:110936564 T/C cg12870014 chr12:110450643 ANKRD13A 0.76 6.63 0.34 1.34e-10 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC cis rs7647973 0.626 rs1491985 chr3:49739507 G/C cg03060546 chr3:49711283 APEH 0.68 8.33 0.42 2.21e-15 Menarche (age at onset); CRC cis rs861020 0.677 rs2049998 chr1:210031154 C/T cg05527609 chr1:210001259 C1orf107 -1.02 -12.9 -0.58 4.34e-31 Orofacial clefts; CRC cis rs11971779 0.527 rs4379397 chr7:139043385 G/A cg23387468 chr7:139079360 LUC7L2 0.41 7.04 0.36 1.14e-11 Diisocyanate-induced asthma; CRC cis rs11098499 0.863 rs13140409 chr4:120503460 A/G cg24375607 chr4:120327624 NA 0.49 7.32 0.37 1.86e-12 Corneal astigmatism; CRC trans rs61931739 0.500 rs6488213 chr12:34393319 C/T cg13010199 chr12:38710504 ALG10B 0.44 6.33 0.33 8.16e-10 Morning vs. evening chronotype; CRC trans rs75804782 0.641 rs60841092 chr2:239349640 G/A cg01134436 chr17:81009848 B3GNTL1 0.75 6.8 0.35 4.95e-11 Morning vs. evening chronotype;Chronotype; CRC trans rs10504229 1.000 rs73607874 chr8:58173433 G/C cg04077850 chr5:125800366 GRAMD3 0.37 6.27 0.33 1.15e-9 Developmental language disorder (linguistic errors); CRC cis rs7113874 0.513 rs2015629 chr11:8564426 A/T cg20771178 chr11:8615675 STK33 -0.36 -5.88 -0.31 1.01e-8 Body mass index in physically active individuals;Body mass index (joint analysis main effects and physical activity interaction); CRC trans rs7011507 1.000 rs79249191 chr8:49193683 A/G cg04544946 chr8:978226 NA 0.45 6.45 0.34 4.09e-10 Inflammatory bowel disease;Ulcerative colitis; CRC cis rs4474465 1.000 rs10793315 chr11:78190716 C/G cg27205649 chr11:78285834 NARS2 -0.48 -5.81 -0.3 1.49e-8 Alzheimer's disease (survival time); CRC cis rs713587 0.520 rs483428 chr2:25305136 A/G cg22495460 chr2:25135724 ADCY3 -0.43 -6.32 -0.33 8.67e-10 Body mass index in non-asthmatics; CRC cis rs4332037 0.539 rs11764590 chr7:2032803 C/T cg21155852 chr7:2048760 MAD1L1 -0.52 -6.98 -0.36 1.63e-11 Bipolar disorder; CRC cis rs561341 1.000 rs484175 chr17:30309041 G/A cg23018236 chr17:30244563 NA -0.67 -8.02 -0.4 1.83e-14 Hip circumference adjusted for BMI; CRC cis rs733592 0.931 rs765260 chr12:48431936 C/T cg21466736 chr12:48725269 NA 0.46 7.32 0.37 1.86e-12 Plateletcrit; CRC cis rs6973256 0.834 rs10244670 chr7:133323417 A/G cg10665199 chr7:133106180 EXOC4 -0.37 -5.68 -0.3 2.95e-8 Intelligence (multi-trait analysis); CRC cis rs7615952 0.641 rs6805074 chr3:125772274 T/A cg02772935 chr3:125709198 NA -0.49 -5.74 -0.3 2.11e-8 Blood pressure (smoking interaction); CRC cis rs7737355 0.947 rs40989 chr5:130992284 T/G cg06307176 chr5:131281290 NA 0.41 5.89 0.31 9.38e-9 Life satisfaction; CRC cis rs2836974 0.897 rs2836933 chr21:40564202 C/G cg17971929 chr21:40555470 PSMG1 0.82 11.67 0.54 1.47e-26 Cognitive function; CRC cis rs73206853 0.620 rs17682644 chr12:111156008 C/T cg12870014 chr12:110450643 ANKRD13A 0.67 6.48 0.34 3.28e-10 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC cis rs10504229 0.683 rs2873638 chr8:58114593 G/A cg02725872 chr8:58115012 NA -0.65 -11.61 -0.54 2.34e-26 Developmental language disorder (linguistic errors); CRC trans rs11825064 0.945 rs56296358 chr11:134478665 C/T cg00033773 chr19:12779366 MORG1;C19orf56 0.52 6.14 0.32 2.43e-9 Seasonality; CRC cis rs2576037 0.526 rs2051292 chr18:44484372 C/G cg24750912 chr18:44543259 TCEB3CL;KATNAL2 0.29 5.73 0.3 2.32e-8 Personality dimensions; CRC cis rs9814567 1.000 rs13081688 chr3:134259954 C/T cg06541857 chr3:134203789 ANAPC13;CEP63 0.4 5.82 0.31 1.38e-8 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC trans rs7395662 0.571 rs1605358 chr11:48689318 T/A cg21153622 chr11:89784906 NA -0.48 -7.67 -0.39 2.02e-13 HDL cholesterol; CRC trans rs3780486 0.713 rs3780489 chr9:33129844 G/T cg20290983 chr6:43655470 MRPS18A 1.16 27.12 0.83 6.77e-86 IgG glycosylation; CRC cis rs7833986 0.501 rs2719261 chr8:56941982 C/G cg23139584 chr8:56987506 RPS20;SNORD54 0.83 11.6 0.54 2.58e-26 Height; CRC trans rs8035957 1.000 rs4924273 chr15:38846738 C/G cg17836132 chr15:51201076 AP4E1 -0.49 -6.2 -0.32 1.65e-9 Type 1 diabetes; CRC cis rs7224737 1.000 rs9889618 chr17:40293467 C/T cg02450064 chr17:40260053 DHX58 -0.42 -6.13 -0.32 2.54e-9 Fibrinogen levels; CRC cis rs3824867 0.920 rs7948705 chr11:47447955 C/G cg05585544 chr11:47624801 NA 0.4 6.17 0.32 2.02e-9 Mean corpuscular hemoglobin; CRC cis rs847577 0.748 rs55784506 chr7:97718201 G/A cg24562669 chr7:97807699 LMTK2 0.76 16.59 0.67 2.42e-45 Breast cancer; CRC cis rs9467711 0.606 rs9358938 chr6:26387546 C/T cg08501292 chr6:25962987 TRIM38 0.87 6.75 0.35 6.7e-11 Autism spectrum disorder or schizophrenia; CRC cis rs7254114 0.578 rs4804574 chr19:11317482 G/A cg02815516 chr19:11306319 KANK2 0.34 6.3 0.33 9.57e-10 Immature fraction of reticulocytes; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg06966887 chr5:443603 EXOC3;C5orf55 0.42 6.01 0.31 5.06e-9 Intelligence (multi-trait analysis); CRC cis rs4243830 0.850 rs7536908 chr1:6607814 C/T cg05709478 chr1:6581295 PLEKHG5 -0.59 -7.04 -0.36 1.11e-11 Body mass index; CRC cis rs739401 0.611 rs2239899 chr11:3024624 A/G cg08508325 chr11:3079039 CARS 0.48 8.76 0.43 1.04e-16 Longevity; CRC cis rs9467773 1.000 rs9295695 chr6:26528250 C/T cg09904177 chr6:26538194 HMGN4 -0.86 -14.85 -0.63 1.53e-38 Intelligence (multi-trait analysis); CRC cis rs7072216 0.666 rs11189592 chr10:100155642 C/A cg26618903 chr10:100175079 PYROXD2 -0.39 -5.95 -0.31 6.92e-9 Metabolite levels; CRC cis rs924607 1.000 rs12523022 chr5:598643 C/T cg24163568 chr5:669837 TPPP -0.43 -6.86 -0.35 3.32e-11 Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia; CRC cis rs561341 1.000 rs72825712 chr17:30316119 A/T cg19193384 chr17:30244184 NA -0.65 -7.51 -0.38 5.62e-13 Hip circumference adjusted for BMI; CRC cis rs6951245 0.938 rs11764937 chr7:1092074 C/T cg22907277 chr7:1156413 C7orf50 0.66 6.96 0.36 1.87e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs7666738 0.830 rs1593572 chr4:98979322 A/G cg05340658 chr4:99064831 C4orf37 -0.61 -9.44 -0.46 7.26e-19 Colonoscopy-negative controls vs population controls; CRC cis rs853679 0.517 rs4713150 chr6:28136212 G/A cg12963246 chr6:28129442 ZNF389 0.49 5.73 0.3 2.31e-8 Depression; CRC cis rs7044106 0.762 rs10984974 chr9:123421556 C/T cg09419670 chr9:123605666 PSMD5;LOC253039 0.7 11.48 0.53 6.94e-26 Hip circumference adjusted for BMI; CRC cis rs7772486 0.875 rs1960885 chr6:146325930 G/T cg23711669 chr6:146136114 FBXO30 0.61 10.3 0.49 9.23e-22 Lobe attachment (rater-scored or self-reported); CRC cis rs7043114 0.525 rs7864630 chr9:95267560 A/C cg13798575 chr9:95087839 CENPP;NOL8 -0.42 -6.27 -0.33 1.17e-9 Height; CRC cis rs853679 0.517 rs9380049 chr6:28048535 A/G cg06470822 chr6:28175283 NA 0.98 13.17 0.59 4.07e-32 Depression; CRC cis rs10971721 0.822 rs72727342 chr9:33938082 G/A cg13495928 chr9:33750294 PRSS3 0.56 5.95 0.31 6.96e-9 Body mass index; CRC cis rs2404602 0.647 rs11852395 chr15:77087785 T/C cg03037974 chr15:76606532 NA -0.51 -7.25 -0.37 2.95e-12 Blood metabolite levels; CRC cis rs55788414 0.789 rs4630561 chr16:81183108 T/C cg06400318 chr16:81190750 PKD1L2 -0.59 -6.76 -0.35 6.2e-11 Left ventricular obstructive tract defect (maternal effect); CRC cis rs10463316 0.832 rs246483 chr5:150731062 C/G cg03212797 chr5:150827313 SLC36A1 -0.51 -8.04 -0.41 1.65e-14 Metabolite levels (Pyroglutamine); CRC cis rs853679 0.513 rs13437444 chr6:28070998 C/T cg12172441 chr6:28176163 NA 0.58 5.72 0.3 2.35e-8 Depression; CRC cis rs681343 1.000 rs492602 chr19:49206417 A/G cg01656853 chr19:49199172 FUT2 0.23 5.61 0.3 4.3e-8 Lung adenocarcinoma;Primary sclerosing cholangitis;Childhood ear infection; CRC cis rs8114671 0.967 rs4911476 chr20:33780768 A/C cg08999081 chr20:33150536 PIGU -0.35 -5.68 -0.3 2.95e-8 Height; CRC cis rs6662572 1.000 rs11587982 chr1:46161868 A/T cg03123370 chr1:45965343 CCDC163P;MMACHC 0.51 6.12 0.32 2.64e-9 Blood protein levels; CRC cis rs10504229 0.954 rs903717 chr8:58167856 A/G cg05313129 chr8:58192883 C8orf71 -0.4 -6.91 -0.36 2.46e-11 Developmental language disorder (linguistic errors); CRC cis rs9287719 0.578 rs7598541 chr2:10700516 G/A cg00105475 chr2:10696890 NA 0.48 7.31 0.37 2.11e-12 Prostate cancer; CRC cis rs7591163 1.000 rs2056566 chr2:228713241 G/A cg23807890 chr2:228736357 WDR69 -0.51 -6.99 -0.36 1.56e-11 Blood pressure; CRC cis rs8177253 1.000 rs8177253 chr3:133480192 A/G cg16262614 chr3:133464971 TF -0.32 -5.69 -0.3 2.82e-8 Iron status biomarkers; CRC cis rs2836974 0.897 rs13052882 chr21:40555351 G/C cg11890956 chr21:40555474 PSMG1 1.12 21.01 0.76 9.29e-63 Cognitive function; CRC cis rs6121246 0.609 rs6060955 chr20:30385071 A/G cg13852791 chr20:30311386 BCL2L1 0.74 14.66 0.63 8.2e-38 Mean corpuscular hemoglobin; CRC cis rs7618501 0.633 rs11925192 chr3:50038664 G/A cg05623727 chr3:50126028 RBM5 0.46 7.82 0.4 7.12e-14 Intelligence (multi-trait analysis); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg26933736 chr6:83902998 RWDD2A;PGM3 0.4 6.38 0.33 6.04e-10 Liver disease severity in Alagille syndrome; CRC cis rs12464483 0.591 rs4952170 chr2:30885429 G/A cg12454169 chr2:30669597 LCLAT1 0.68 7.77 0.39 1.04e-13 Pre-treatment pain in head and neck squamous cell carcinoma; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg11716640 chr1:113933411 MAGI3 0.46 6.16 0.32 2.17e-9 Thyroid stimulating hormone; CRC cis rs875971 0.862 rs17747530 chr7:65994729 G/C cg18876405 chr7:65276391 NA 0.52 8.38 0.42 1.6e-15 Aortic root size; CRC cis rs1059312 1.000 rs7970815 chr12:129288366 G/A cg04043695 chr12:129287642 SLC15A4 0.39 5.95 0.31 6.95e-9 Systemic lupus erythematosus; CRC cis rs12479064 0.724 rs2309618 chr2:99974473 G/A cg26064155 chr2:99771622 LIPT1;TSGA10 -0.63 -7.44 -0.38 8.92e-13 Chronic sinus infection; CRC cis rs6951245 1.000 rs78143408 chr7:1096846 G/A cg07217954 chr7:1067459 C7orf50 0.55 5.72 0.3 2.36e-8 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs2204008 0.837 rs11612397 chr12:38357455 T/C cg13010199 chr12:38710504 ALG10B 0.47 6.3 0.33 9.3e-10 Bladder cancer; CRC cis rs7666738 0.830 rs13115356 chr4:98933171 T/C cg05340658 chr4:99064831 C4orf37 0.6 9.35 0.46 1.41e-18 Colonoscopy-negative controls vs population controls; CRC cis rs4713118 0.662 rs9393881 chr6:28023751 C/G cg06470822 chr6:28175283 NA 0.92 13.0 0.58 1.83e-31 Parkinson's disease; CRC cis rs10256972 0.552 rs2960837 chr7:1203957 A/G cg09177884 chr7:1199841 ZFAND2A -0.5 -7.41 -0.38 1.09e-12 Longevity;Endometriosis; CRC cis rs916888 0.773 rs9896243 chr17:44826056 C/G cg17911788 chr17:44343683 NA -0.56 -6.33 -0.33 8.02e-10 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs9303401 0.527 rs12946522 chr17:56768103 A/C cg02118635 chr17:56770003 RAD51C;TEX14 0.73 8.8 0.44 8.11e-17 Cognitive test performance; CRC cis rs3996993 0.809 rs12528332 chr6:52687392 G/A cg20803780 chr6:52668592 GSTA1 0.36 6.48 0.34 3.44e-10 Hemoglobin concentration; CRC cis rs10504229 1.000 rs57261109 chr8:58172152 C/T cg02290350 chr8:58132656 NA -0.42 -5.96 -0.31 6.62e-9 Developmental language disorder (linguistic errors); CRC cis rs868036 1.000 rs1026731 chr15:68095018 G/A cg05925327 chr15:68127851 NA -0.31 -6.01 -0.31 4.84e-9 Restless legs syndrome; CRC trans rs12599106 0.792 rs12597352 chr16:34638507 A/T cg11235426 chr6:292522 DUSP22 -0.54 -7.7 -0.39 1.62e-13 Menopause (age at onset); CRC cis rs7845219 0.506 rs12548999 chr8:95929843 C/T cg16049864 chr8:95962084 TP53INP1 -0.4 -5.98 -0.31 5.75e-9 Type 2 diabetes; CRC cis rs10504073 0.647 rs10435574 chr8:49996028 G/A cg00325661 chr8:49890786 NA 0.52 9.36 0.46 1.32e-18 Blood metabolite ratios; CRC cis rs7666738 0.512 rs165251 chr4:98758490 C/G cg05340658 chr4:99064831 C4orf37 0.47 6.88 0.35 3.09e-11 Colonoscopy-negative controls vs population controls; CRC cis rs2252790 1.000 rs10456906 chr6:116621035 C/A cg18764771 chr6:116381957 FRK 0.22 5.92 0.31 8.17e-9 Fast beta electroencephalogram; CRC cis rs4819052 0.851 rs2838832 chr21:46664904 A/G cg19498844 chr21:46707878 POFUT2;LOC642852 -0.76 -10.57 -0.5 1.13e-22 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC trans rs1814175 0.754 rs28593359 chr11:50042357 C/T cg15704280 chr7:45808275 SEPT13 -0.97 -19.11 -0.73 2.72e-55 Height; CRC cis rs12922317 0.538 rs442234 chr16:12072161 A/G cg02368508 chr16:12060182 TNFRSF17 0.43 6.87 0.35 3.16e-11 Schizophrenia; CRC cis rs1873147 1.000 rs4774470 chr15:63312119 G/A cg12160578 chr15:63334699 TPM1 -0.4 -5.74 -0.3 2.13e-8 Orofacial clefts; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg21468385 chr11:120207433 ARHGEF12 0.4 6.22 0.32 1.47e-9 Liver disease severity in Alagille syndrome; CRC cis rs4713118 0.869 rs9366700 chr6:27696951 C/T cg12172441 chr6:28176163 NA 0.52 7.19 0.37 4.51e-12 Parkinson's disease; CRC cis rs10221833 0.602 rs355882 chr2:165633761 T/C cg03182029 chr2:165697222 COBLL1 0.49 5.8 0.3 1.56e-8 Response to statin therapy; CRC cis rs10883723 0.810 rs2296588 chr10:104248087 T/C cg04362960 chr10:104952993 NT5C2 -0.43 -6.01 -0.31 4.81e-9 Allergic disease (asthma, hay fever or eczema); CRC trans rs6819266 0.636 rs13148734 chr4:63330858 A/G cg13402217 chr1:151584375 SNX27 0.39 6.16 0.32 2.07e-9 Age-related macular degeneration; CRC cis rs8177253 0.965 rs7638018 chr3:133495461 C/T cg08048268 chr3:133502702 NA 0.38 7.24 0.37 3.19e-12 Iron status biomarkers; CRC cis rs10256972 0.706 rs12701969 chr7:1121849 A/G cg23708337 chr7:1209742 NA 0.41 5.9 0.31 9.03e-9 Longevity;Endometriosis; CRC trans rs1005277 0.540 rs2224248 chr10:38451886 A/G cg23533926 chr12:111358616 MYL2 -0.52 -7.87 -0.4 5.24e-14 Extrinsic epigenetic age acceleration; CRC cis rs6860806 0.507 rs2631362 chr5:131707293 A/G cg04518342 chr5:131593106 PDLIM4 -0.44 -7.1 -0.36 7.91e-12 Breast cancer; CRC cis rs908922 0.542 rs4845785 chr1:152510143 C/T cg23254163 chr1:152506842 NA 0.51 10.12 0.49 3.97e-21 Hair morphology; CRC cis rs7772486 0.875 rs2748498 chr6:146319166 C/G cg23711669 chr6:146136114 FBXO30 0.67 11.32 0.53 2.72e-25 Lobe attachment (rater-scored or self-reported); CRC cis rs8180040 0.764 rs13084117 chr3:47183239 C/A cg10298567 chr3:47292165 KIF9 -0.36 -5.77 -0.3 1.8e-8 Colorectal cancer; CRC cis rs1451375 0.617 rs10277662 chr7:50594836 C/T cg18232548 chr7:50535776 DDC 0.45 5.89 0.31 9.48e-9 Malaria; CRC cis rs950169 0.512 rs4374136 chr15:84645007 C/G cg17507749 chr15:85114479 UBE2QP1 0.62 7.77 0.39 1.02e-13 Schizophrenia; CRC cis rs34787248 1 rs34787248 chr6:28197886 C/T cg25164649 chr6:28176230 NA 0.59 6.31 0.33 8.79e-10 Autism spectrum disorder or schizophrenia; CRC cis rs909674 0.818 rs5757678 chr22:39843409 A/G cg24399712 chr22:39784796 NA 0.43 8.75 0.43 1.15e-16 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; CRC trans rs9393777 0.920 rs35716472 chr6:27406607 C/G cg06606381 chr12:133084897 FBRSL1 -0.97 -6.86 -0.35 3.38e-11 Intelligence (multi-trait analysis); CRC cis rs4588572 0.644 rs6870646 chr5:77741082 G/A cg11547950 chr5:77652471 NA -0.48 -7.04 -0.36 1.14e-11 Triglycerides; CRC trans rs9929218 0.954 rs4552018 chr16:68822854 T/G cg04657470 chr2:198365150 HSPE1;HSPD1 -0.78 -11.2 -0.53 6.79e-25 Colorectal cancer; CRC cis rs7824557 1.000 rs2736371 chr8:11105529 A/G cg20542592 chr8:11973495 FAM66D 0.35 5.62 0.3 4.02e-8 Retinal vascular caliber; CRC cis rs58688157 0.705 rs7928902 chr11:609068 G/A cg02461776 chr11:598696 PHRF1 0.46 5.88 0.31 1.03e-8 Systemic lupus erythematosus; CRC cis rs7552404 1.000 rs11161515 chr1:76212559 C/T cg03433033 chr1:76189801 ACADM 0.82 11.22 0.53 5.97e-25 Blood metabolite levels;Acylcarnitine levels; CRC cis rs13191362 0.872 rs67712738 chr6:163245768 G/A cg06582575 chr6:163149167 PACRG;PARK2 0.69 8.74 0.43 1.19e-16 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg05940971 chr14:93651131 MOAP1;C14orf109 0.42 6.61 0.34 1.6e-10 Liver disease severity in Alagille syndrome; CRC cis rs7833790 0.724 rs6473299 chr8:82676936 A/G cg27398817 chr8:82754497 SNX16 -0.48 -5.84 -0.31 1.26e-8 Diastolic blood pressure; CRC cis rs7246865 0.954 rs1060367 chr19:17215202 G/A cg19418318 chr19:17219073 MYO9B 0.5 8.52 0.43 5.69e-16 Reticulocyte fraction of red cells; CRC cis rs4481887 1.000 rs4244174 chr1:248467956 A/G cg13385794 chr1:248469461 NA 0.38 6.8 0.35 5.07e-11 Common traits (Other); CRC cis rs6502050 0.835 rs8075086 chr17:80092649 A/G cg25804541 chr17:80189381 SLC16A3 -0.3 -5.74 -0.3 2.2e-8 Life satisfaction; CRC cis rs8105895 0.935 rs10408150 chr19:22245225 T/C cg02657401 chr19:22469223 NA -0.34 -5.65 -0.3 3.56e-8 Body mass index (change over time); CRC cis rs8005677 0.798 rs4536383 chr14:23410926 T/C cg25600027 chr14:23388339 RBM23 -0.42 -6.3 -0.33 9.66e-10 Cognitive ability (multi-trait analysis); CRC cis rs4862750 0.915 rs6835681 chr4:187903476 A/G cg22105103 chr4:187893119 NA 0.68 12.43 0.57 2.44e-29 Lobe attachment (rater-scored or self-reported); CRC cis rs9467773 0.584 rs1021372 chr6:26632444 T/C cg09904177 chr6:26538194 HMGN4 0.72 11.39 0.53 1.42e-25 Intelligence (multi-trait analysis); CRC trans rs2797369 0.771 rs2813643 chr6:101575509 G/T cg26346621 chr12:6873348 NA 0.38 6.12 0.32 2.66e-9 Renal function-related traits (eGRFcrea); CRC cis rs9486715 1.000 rs2273621 chr6:97058553 A/G cg06623918 chr6:96969491 KIAA0776 -0.98 -17.93 -0.7 1.26e-50 Headache; CRC trans rs116095464 0.558 rs62347683 chr5:230331 C/T cg00938859 chr5:1591904 SDHAP3 0.72 7.98 0.4 2.49e-14 Breast cancer; CRC cis rs2836950 0.565 rs7279497 chr21:40531306 A/G cg11644478 chr21:40555479 PSMG1 0.5 7.45 0.38 8.37e-13 Menarche (age at onset); CRC cis rs727505 0.607 rs17387591 chr7:124799471 A/G cg23710748 chr7:124431027 NA -0.58 -9.67 -0.47 1.27e-19 Lewy body disease; CRC cis rs6964587 0.869 rs405 chr7:91546327 G/C cg17063962 chr7:91808500 NA -0.74 -12.28 -0.56 8.57e-29 Breast cancer; CRC cis rs76878669 0.516 rs7104570 chr11:66159098 A/G cg18002602 chr11:66138449 SLC29A2 0.31 6.59 0.34 1.73e-10 Educational attainment (years of education); CRC cis rs62064224 0.614 rs728718 chr17:30708960 T/G cg18200150 chr17:30822561 MYO1D 0.44 8.52 0.43 5.79e-16 Schizophrenia; CRC cis rs733592 0.507 rs10875739 chr12:48480919 C/T cg21466736 chr12:48725269 NA -0.49 -7.62 -0.39 2.7e-13 Plateletcrit; CRC cis rs3785574 0.962 rs2584623 chr17:61906679 G/A cg23090583 chr17:61904693 PSMC5;FTSJ3 0.65 9.26 0.45 2.71e-18 Height; CRC cis rs6582630 0.502 rs4309219 chr12:38293584 A/G cg26384229 chr12:38710491 ALG10B 0.67 9.96 0.48 1.32e-20 Drug-induced liver injury (flucloxacillin); CRC cis rs35110281 0.720 rs162393 chr21:44942692 G/A cg04455712 chr21:45112962 RRP1B 0.43 8.24 0.41 4.1e-15 Mean corpuscular volume; CRC cis rs28386778 0.897 rs2584626 chr17:61903179 A/G cg06601766 chr17:61851465 DDX42;CCDC47 0.44 5.96 0.31 6.33e-9 Prudent dietary pattern; CRC cis rs3785574 0.962 rs2584623 chr17:61906679 G/A cg11494091 chr17:61959527 GH2 0.37 5.66 0.3 3.34e-8 Height; CRC cis rs7615952 0.866 rs1976459 chr3:125647486 A/T cg05084668 chr3:125655381 ALG1L -0.61 -9.24 -0.45 3.08e-18 Blood pressure (smoking interaction); CRC cis rs9457247 0.740 rs10946204 chr6:167451129 T/C cg23791538 chr6:167370224 RNASET2 -0.38 -5.75 -0.3 2.09e-8 Crohn's disease; CRC cis rs344364 0.511 rs911391 chr16:1947016 C/A cg14074117 chr16:1909714 C16orf73 0.42 5.85 0.31 1.2e-8 Glomerular filtration rate in chronic kidney disease; CRC cis rs1552244 0.882 rs68080705 chr3:10025743 C/T cg08888203 chr3:10149979 C3orf24 0.61 8.03 0.4 1.8e-14 Alzheimer's disease; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg16421803 chr2:25194856 DNAJC27 0.42 6.34 0.33 7.77e-10 Intelligence (multi-trait analysis); CRC cis rs17756712 0.725 rs17135679 chr6:614787 T/C cg16786516 chr6:604617 EXOC2 0.46 5.71 0.3 2.46e-8 Vertical cup-disc ratio; CRC cis rs2032447 0.802 rs199755 chr6:25990367 G/A cg12310025 chr6:25882481 NA -0.57 -7.93 -0.4 3.53e-14 Intelligence (multi-trait analysis); CRC cis rs2204008 0.837 rs11168387 chr12:37962818 G/A cg26384229 chr12:38710491 ALG10B -0.64 -9.74 -0.47 7.41e-20 Bladder cancer; CRC cis rs10504229 0.817 rs10504230 chr8:58197150 A/G cg24829409 chr8:58192753 C8orf71 0.6 8.44 0.42 1.02e-15 Developmental language disorder (linguistic errors); CRC cis rs910187 0.605 rs6063080 chr20:45805091 G/A cg27589058 chr20:45804311 EYA2 -0.4 -7.8 -0.39 8.38e-14 Migraine; CRC cis rs2213920 0.679 rs9409160 chr9:118227046 G/A cg13918206 chr9:118159781 DEC1 0.64 6.07 0.32 3.49e-9 Docetaxel-induced peripheral neuropathy in metastatic castrate-resistant prostate cancer; CRC cis rs1448094 0.967 rs2044617 chr12:86324089 T/C cg02569458 chr12:86230093 RASSF9 0.37 6.47 0.34 3.47e-10 Major depressive disorder; CRC cis rs1150668 0.830 rs2531831 chr6:28388765 C/G cg15845792 chr6:28175446 NA 0.48 6.96 0.36 1.82e-11 Pubertal anthropometrics; CRC cis rs11625487 0.915 rs11845826 chr14:77966145 C/A cg16049707 chr14:77965284 ISM2 0.43 5.84 0.31 1.23e-8 Neutrophil percentage of white cells;Sum neutrophil eosinophil counts;Neutrophil count; CRC cis rs3760982 1.000 rs10405457 chr19:44296582 G/T cg11993925 chr19:44307056 LYPD5 0.47 7.82 0.4 7.09e-14 Breast cancer (estrogen-receptor negative);Breast cancer; CRC cis rs3736485 0.932 rs2278990 chr15:51914662 G/A cg08986416 chr15:51914746 DMXL2 -0.46 -6.53 -0.34 2.49e-10 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs365302 1.000 rs444245 chr6:159642963 C/T cg14500486 chr6:159655392 FNDC1 0.45 6.73 0.35 7.76e-11 Coronary heart disease; CRC cis rs477692 0.549 rs7098548 chr10:131455028 A/G cg05714579 chr10:131428358 MGMT -0.5 -6.88 -0.35 2.97e-11 Response to temozolomide; CRC cis rs8077889 0.956 rs6503476 chr17:41850163 C/T cg25876840 chr17:41920477 NA 0.48 6.9 0.36 2.67e-11 Triglycerides; CRC cis rs6502050 0.835 rs7501527 chr17:80099355 A/C cg09264619 chr17:80180166 NA -0.38 -6.46 -0.34 3.81e-10 Life satisfaction; CRC trans rs1945380 1.000 rs4118071 chr11:80425472 A/T cg01496416 chr19:45147715 PVR 0.45 5.97 0.31 5.99e-9 Diabetic kidney disease; CRC cis rs79839061 0.562 rs62294484 chr4:935571 A/G cg14530993 chr4:882597 GAK 0.78 7.44 0.38 9.04e-13 Intelligence (multi-trait analysis); CRC cis rs7666738 0.830 rs62321597 chr4:99014221 C/A cg05340658 chr4:99064831 C4orf37 0.61 9.54 0.47 3.43e-19 Colonoscopy-negative controls vs population controls; CRC cis rs9875589 0.957 rs6768050 chr3:13930490 A/G cg14375111 chr3:14165186 TMEM43;CHCHD4 -0.38 -5.62 -0.3 4.04e-8 Ovarian reserve; CRC cis rs6547741 1.000 rs6706610 chr2:27778091 G/A cg27432699 chr2:27873401 GPN1 0.75 13.33 0.59 1.05e-32 Oral cavity cancer; CRC cis rs599083 0.530 rs686921 chr11:68170833 G/T cg16797656 chr11:68205561 LRP5 -0.38 -6.2 -0.32 1.71e-9 Bone mineral density (spine); CRC cis rs9583531 0.689 rs6492308 chr13:111377829 T/C cg24331049 chr13:111365604 ING1 0.52 6.86 0.35 3.35e-11 Coronary artery disease; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg25974723 chr19:50119415 PRR12 -0.37 -5.98 -0.31 5.88e-9 Liver disease severity in Alagille syndrome; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg05019311 chr17:4807065 CHRNE 0.45 6.62 0.34 1.48e-10 Response to antipsychotic treatment; CRC cis rs9322193 0.962 rs35031906 chr6:149998574 T/C cg05861140 chr6:150128134 PCMT1 -0.43 -6.99 -0.36 1.5e-11 Lung cancer; CRC cis rs13256369 0.802 rs11249883 chr8:8561537 G/A cg17143192 chr8:8559678 CLDN23 0.5 6.44 0.33 4.22e-10 Obesity-related traits; CRC cis rs7705042 0.759 rs3765011 chr5:141517665 G/C cg07392085 chr5:141489673 NDFIP1 0.45 7.29 0.37 2.34e-12 Asthma; CRC cis rs7786808 0.707 rs10247026 chr7:158230595 C/T cg01191920 chr7:158217561 PTPRN2 -0.92 -18.09 -0.71 2.95e-51 Obesity-related traits; CRC cis rs1799949 1.000 rs8176273 chr17:41211653 A/G cg23758822 chr17:41437982 NA 0.81 13.51 0.6 2.08e-33 Menopause (age at onset); CRC cis rs6089584 0.528 rs4925335 chr20:60627034 G/A cg13770153 chr20:60521292 NA -0.44 -6.53 -0.34 2.43e-10 Body mass index; CRC cis rs1055129 0.516 rs7218498 chr17:73931847 C/G cg14829360 chr17:73884958 NA -0.34 -5.85 -0.31 1.18e-8 White matter hyperintensity burden; CRC trans rs11039798 0.699 rs7120775 chr11:48266736 C/G cg15704280 chr7:45808275 SEPT13 0.67 6.4 0.33 5.39e-10 Axial length; CRC cis rs2932538 0.961 rs2932539 chr1:113215786 A/G cg22162597 chr1:113214053 CAPZA1 -0.68 -9.67 -0.47 1.26e-19 Systolic blood pressure;Diastolic blood pressure;Hypertension;Blood pressure; CRC trans rs208520 1.000 rs208537 chr6:66963544 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.89 -11.02 -0.52 2.96e-24 Exhaled nitric oxide output; CRC cis rs3733585 0.638 rs6414766 chr4:9956474 G/A cg00071950 chr4:10020882 SLC2A9 -0.54 -9.67 -0.47 1.21e-19 Cleft plate (environmental tobacco smoke interaction); CRC cis rs1862618 0.853 rs252904 chr5:56118733 A/T cg24531977 chr5:56204891 C5orf35 -0.76 -10.55 -0.5 1.32e-22 Initial pursuit acceleration; CRC cis rs911119 0.954 rs116786204 chr20:23599918 T/G cg16589663 chr20:23618590 CST3 0.44 6.16 0.32 2.12e-9 Chronic kidney disease; CRC cis rs4665809 1.000 rs6546766 chr2:26328680 T/C cg25036284 chr2:26402008 FAM59B -0.45 -5.86 -0.31 1.14e-8 Gut microbiome composition (summer); CRC cis rs911186 0.680 rs34783558 chr6:27171700 T/C cg12292205 chr6:26970375 C6orf41 -0.77 -8.23 -0.41 4.37e-15 Autism spectrum disorder or schizophrenia; CRC cis rs13108904 0.901 rs4516656 chr4:1279860 A/G cg21620606 chr4:1342894 KIAA1530 0.36 5.89 0.31 9.62e-9 Obesity-related traits; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg04215179 chr7:23719682 C7orf46 0.43 6.98 0.36 1.63e-11 Liver disease severity in Alagille syndrome; CRC cis rs9818758 0.607 rs11706189 chr3:49210833 C/A cg00383909 chr3:49044727 WDR6 1.05 10.14 0.49 3.36e-21 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; CRC cis rs2839186 0.934 rs2839194 chr21:47699437 T/G cg02776659 chr21:47717406 C21orf57 -0.33 -5.63 -0.3 3.79e-8 Testicular germ cell tumor; CRC cis rs9894429 0.621 rs9747119 chr17:79607017 A/G cg21984481 chr17:79567631 NPLOC4 -0.45 -7.86 -0.4 5.54e-14 Eye color traits; CRC trans rs9858542 0.953 rs11926781 chr3:49603289 C/T cg21659725 chr3:3221576 CRBN -0.71 -9.67 -0.47 1.24e-19 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs926938 0.527 rs360584 chr1:115463181 G/A cg12756093 chr1:115239321 AMPD1 0.48 6.99 0.36 1.51e-11 Autism; CRC cis rs10206020 0.842 rs7609325 chr2:1574718 G/A cg26248373 chr2:1572462 NA -0.83 -12.38 -0.56 3.62e-29 IgG glycosylation; CRC cis rs1008375 1.000 rs10939749 chr4:17692319 A/C cg16339924 chr4:17578868 LAP3 0.47 6.31 0.33 8.96e-10 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs2404602 0.669 rs1875885 chr15:76638081 G/A cg23625390 chr15:77176239 SCAPER 0.5 7.22 0.37 3.66e-12 Blood metabolite levels; CRC cis rs1005277 0.579 rs2504148 chr10:38400788 A/G cg17219203 chr10:38645113 HSD17B7P2 -0.41 -5.8 -0.3 1.54e-8 Extrinsic epigenetic age acceleration; CRC cis rs11212617 0.967 rs3781868 chr11:108059569 T/G cg01991180 chr11:108092276 ATM;NPAT 0.43 6.43 0.33 4.44e-10 Response to metformin in type 2 diabetes (glycemic); CRC cis rs863345 0.604 rs12118446 chr1:158496235 T/C cg12129480 chr1:158549410 OR10X1 -0.29 -5.95 -0.31 6.94e-9 Pneumococcal bacteremia; CRC cis rs733592 0.507 rs7304428 chr12:48494275 T/G cg21466736 chr12:48725269 NA 0.51 8.01 0.4 1.96e-14 Plateletcrit; CRC cis rs8105895 0.935 rs62111028 chr19:22272397 A/T cg02912127 chr19:22235281 ZNF257 -0.41 -5.7 -0.3 2.62e-8 Body mass index (change over time); CRC cis rs7193541 0.508 rs7188581 chr16:74672901 T/A cg01733217 chr16:74700730 RFWD3 1.05 21.04 0.76 7.53e-63 Multiple myeloma; CRC cis rs600626 0.588 rs10160802 chr11:75457950 A/C cg24262691 chr11:75473276 NA 0.5 7.27 0.37 2.71e-12 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CRC cis rs9611565 0.802 rs4822028 chr22:41789408 A/G cg06634786 chr22:41940651 POLR3H -0.58 -6.85 -0.35 3.68e-11 Vitiligo; CRC cis rs6952808 0.756 rs4719311 chr7:1881813 C/T cg05279229 chr7:1896384 MAD1L1 -0.35 -5.67 -0.3 3.15e-8 Bipolar disorder and schizophrenia; CRC cis rs1046896 1.000 rs1046896 chr17:80685533 A/G cg17346650 chr17:80929145 B3GNTL1 -0.38 -6.2 -0.32 1.69e-9 Glycated hemoglobin levels; CRC cis rs7216064 1.000 rs2365764 chr17:65857714 G/A cg12091567 chr17:66097778 LOC651250 -0.68 -7.87 -0.4 5.31e-14 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CRC cis rs8053891 0.615 rs34042070 chr16:72101525 C/G cg23815491 chr16:72088622 HP 0.54 5.84 0.31 1.22e-8 Coronary artery disease; CRC cis rs4819052 1.000 rs2838847 chr21:46670958 G/C cg02159808 chr21:46707872 POFUT2;LOC642852 0.6 7.66 0.39 2.16e-13 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs546131 0.963 rs539044 chr11:34841542 G/T cg06937548 chr11:34938143 PDHX;APIP 0.42 6.33 0.33 8.21e-10 Lung disease severity in cystic fibrosis; CRC cis rs7623687 0.786 rs73082337 chr3:49009570 C/G cg19401529 chr3:49056140 DALRD3 0.55 6.05 0.32 4.03e-9 Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease);Coronary artery disease; CRC cis rs2223471 0.754 rs2744490 chr6:50765876 T/A cg03432817 chr6:50765336 NA 0.43 6.93 0.36 2.24e-11 Subcutaneous adipose tissue; CRC cis rs3741404 0.620 rs2236648 chr11:63964657 C/T cg06243084 chr11:63990629 FERMT3 -0.4 -6.17 -0.32 2e-9 Platelet count; CRC cis rs4713118 0.869 rs9283880 chr6:27715243 A/C cg15786705 chr6:28176104 NA 0.55 7.78 0.39 9.76e-14 Parkinson's disease; CRC cis rs78456975 1.000 rs11903168 chr2:1560497 C/G cg01028140 chr2:1542097 TPO -0.58 -6.13 -0.32 2.54e-9 Placebo response in major depressive disorder (% change in symptom score); CRC cis rs1570884 0.890 rs7333969 chr13:50123317 C/T cg08779649 chr13:50194554 NA 0.35 6.62 0.34 1.46e-10 Sum basophil neutrophil counts;Sum neutrophil eosinophil counts;Neutrophil count;Myeloid white cell count;Granulocyte count; CRC cis rs13082711 0.863 rs77135084 chr3:27423549 A/C cg02860705 chr3:27208620 NA 0.61 8.81 0.44 7.23e-17 Systolic blood pressure;Diastolic blood pressure;Blood pressure; CRC cis rs12519773 0.501 rs4449514 chr5:92521022 T/C cg18783429 chr5:92414398 NA 0.27 5.73 0.3 2.25e-8 Migraine; CRC cis rs875971 0.862 rs6958294 chr7:65794796 C/A cg11764359 chr7:65958608 NA -0.58 -8.57 -0.43 4.21e-16 Aortic root size; CRC cis rs13191362 0.938 rs13213746 chr6:163167777 T/A cg21926612 chr6:163149169 PACRG;PARK2 0.82 11.31 0.53 2.81e-25 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC trans rs13046373 0.905 rs4816372 chr21:32077414 A/T cg15123572 chr13:114911570 NA -0.39 -6.1 -0.32 3.04e-9 HDL cholesterol; CRC cis rs72781680 0.898 rs112985192 chr2:24102797 G/A cg08917208 chr2:24149416 ATAD2B 0.87 8.56 0.43 4.43e-16 Lymphocyte counts; CRC trans rs875971 0.660 rs2191268 chr7:66110224 C/T cg23156475 chr20:18269111 ZNF133 -0.38 -6.11 -0.32 2.82e-9 Aortic root size; CRC cis rs7552404 0.731 rs11588578 chr1:76400539 T/G cg03433033 chr1:76189801 ACADM 0.62 7.58 0.39 3.59e-13 Blood metabolite levels;Acylcarnitine levels; CRC cis rs701145 0.556 rs191651 chr3:153973887 T/G cg16511985 chr3:153974050 SGEF 0.43 5.72 0.3 2.43e-8 Coronary artery disease; CRC cis rs796364 0.951 rs7565005 chr2:201013277 A/G cg25936922 chr2:200820526 C2orf60;C2orf47 -0.64 -6.89 -0.36 2.85e-11 Schizophrenia; CRC cis rs7312933 0.558 rs7965743 chr12:42736822 A/G cg11827402 chr12:42719852 PPHLN1;ZCRB1 -0.67 -9.85 -0.48 3.23e-20 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CRC cis rs13064411 0.518 rs7623919 chr3:113219160 A/G cg18753928 chr3:113234510 CCDC52 -0.48 -7.72 -0.39 1.42e-13 Response to simvastatin treatment (PCSK9 protein level change); CRC cis rs243505 0.762 rs3779036 chr7:148488507 C/T cg09806900 chr7:148480153 CUL1 0.52 7.56 0.38 3.94e-13 Inflammatory bowel disease;Crohn's disease; CRC cis rs2952156 0.652 rs11869286 chr17:37813856 C/G cg07936489 chr17:37558343 FBXL20 -0.52 -7.82 -0.4 7.45e-14 Asthma; CRC cis rs2439831 0.681 rs28594657 chr15:43588888 C/A cg15269541 chr15:43626905 ADAL -0.62 -6.32 -0.33 8.41e-10 Lung cancer in ever smokers; CRC cis rs1552244 0.554 rs6762397 chr3:10007840 C/T cg00166722 chr3:10149974 C3orf24 0.42 6.28 0.33 1.1e-9 Alzheimer's disease; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg00789034 chr6:158245090 SNX9 0.46 6.35 0.33 7.1e-10 Response to antipsychotic treatment; CRC cis rs853679 0.517 rs9393895 chr6:28127621 T/C cg03623178 chr6:28175578 NA 0.96 12.36 0.56 4.32e-29 Depression; CRC cis rs1448094 0.512 rs11503595 chr12:86244075 T/A cg25456477 chr12:86230367 RASSF9 0.32 5.67 0.3 3.13e-8 Major depressive disorder; CRC cis rs6951245 1.000 rs79765398 chr7:1073764 A/G cg26224354 chr7:1096374 C7orf50;GPR146 -0.89 -11.22 -0.53 5.81e-25 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs2415984 0.583 rs2642090 chr14:46968788 C/T cg14871534 chr14:47121158 RPL10L 0.39 5.93 0.31 7.78e-9 Number of children ever born; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg24419099 chr11:47270565 NR1H3;ACP2 0.42 5.96 0.31 6.45e-9 Response to antipsychotic treatment; CRC cis rs1005277 0.579 rs2472181 chr10:38386764 T/C cg00409905 chr10:38381863 ZNF37A -0.68 -11.32 -0.53 2.64e-25 Extrinsic epigenetic age acceleration; CRC cis rs1223397 0.651 rs2439537 chr6:13307824 C/T cg20827128 chr6:13274284 PHACTR1 0.39 5.99 0.31 5.56e-9 Blood pressure; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg02273769 chr5:171433860 FBXW11 0.45 6.17 0.32 2.03e-9 Response to antipsychotic treatment; CRC cis rs858239 0.796 rs433395 chr7:23401955 G/T cg00469287 chr7:23338798 C7orf30 0.45 6.23 0.32 1.4e-9 Cerebrospinal fluid biomarker levels; CRC cis rs950776 0.518 rs62008174 chr15:78808947 C/T cg06917634 chr15:78832804 PSMA4 0.67 10.62 0.51 7.51e-23 Sudden cardiac arrest; CRC cis rs7312933 0.703 rs10880259 chr12:42558003 T/C cg19980929 chr12:42632907 YAF2 0.44 6.54 0.34 2.32e-10 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CRC cis rs4665809 0.590 rs66477033 chr2:26472497 T/C cg04944784 chr2:26401820 FAM59B 0.85 11.05 0.52 2.29e-24 Gut microbiome composition (summer); CRC cis rs9443645 0.901 rs1538235 chr6:79689450 C/T cg05283184 chr6:79620031 NA -0.59 -9.23 -0.45 3.46e-18 Intelligence (multi-trait analysis); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg03664139 chr6:101329504 ASCC3 0.48 6.88 0.35 3.07e-11 Response to antipsychotic treatment; CRC cis rs9399135 0.967 rs9373122 chr6:135373534 G/A cg22676075 chr6:135203613 NA 0.39 6.03 0.32 4.51e-9 Red blood cell count; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg20093577 chr11:65819742 SF3B2 0.45 6.36 0.33 6.82e-10 Anxiety disorder; CRC cis rs7737355 0.947 rs1422081 chr5:130776053 A/C cg06307176 chr5:131281290 NA 0.45 6.65 0.34 1.22e-10 Life satisfaction; CRC cis rs6500395 1.000 rs1106386 chr16:48593065 C/A cg04672837 chr16:48644449 N4BP1 0.44 6.47 0.34 3.45e-10 Response to tocilizumab in rheumatoid arthritis; CRC cis rs1552244 1.000 rs3895942 chr3:10108745 G/C cg10729496 chr3:10149963 C3orf24 0.52 6.93 0.36 2.21e-11 Alzheimer's disease; CRC cis rs9858542 0.953 rs9853683 chr3:49512588 A/G cg03060546 chr3:49711283 APEH -0.47 -6.56 -0.34 2.08e-10 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs17767392 0.918 rs61991201 chr14:71762623 T/C cg13720639 chr14:72061746 SIPA1L1 -0.53 -6.86 -0.35 3.45e-11 Mitral valve prolapse; CRC cis rs881375 0.678 rs3761846 chr9:123689597 C/T cg09419670 chr9:123605666 PSMD5;LOC253039 0.45 6.8 0.35 4.85e-11 Rheumatoid arthritis; CRC cis rs12893668 0.703 rs35498576 chr14:104025893 T/C cg08213375 chr14:104286397 PPP1R13B 0.36 5.86 0.31 1.11e-8 Reticulocyte count; CRC cis rs7727544 0.654 rs4705849 chr5:131559199 T/A cg18301423 chr5:131593218 PDLIM4 0.31 5.76 0.3 1.95e-8 Blood metabolite levels; CRC cis rs1552244 0.832 rs66597916 chr3:10195407 T/C cg00166722 chr3:10149974 C3orf24 0.68 7.84 0.4 6.29e-14 Alzheimer's disease; CRC cis rs977987 0.843 rs11644741 chr16:75466433 C/A cg03315344 chr16:75512273 CHST6 0.55 9.12 0.45 7.56e-18 Dupuytren's disease; CRC cis rs807669 0.777 rs9605972 chr22:19253274 C/T cg02655711 chr22:19163373 SLC25A1 0.74 13.74 0.6 2.84e-34 Metabolite levels; CRC cis rs7119 0.604 rs907383 chr15:77870646 A/G cg10437265 chr15:77819839 NA -0.58 -9.75 -0.47 6.92e-20 Type 2 diabetes; CRC trans rs4576506 0.536 rs13299549 chr9:31495659 A/G cg26940518 chr16:1593766 IFT140;TMEM204 -0.65 -6.02 -0.31 4.71e-9 Psychosis and Alzheimer's disease; CRC cis rs7772486 0.686 rs4895684 chr6:146114023 A/C cg13319975 chr6:146136371 FBXO30 0.43 6.46 0.34 3.71e-10 Lobe attachment (rater-scored or self-reported); CRC cis rs9659323 1.000 rs11584380 chr1:119517420 C/T cg26570165 chr1:119541833 NA -0.38 -6.38 -0.33 6.02e-10 Body mass index; CRC cis rs8180040 0.966 rs6765990 chr3:47542894 G/A cg10298567 chr3:47292165 KIF9 -0.36 -5.91 -0.31 8.68e-9 Colorectal cancer; CRC cis rs1957429 0.808 rs7149922 chr14:65334541 C/T cg23373153 chr14:65346875 NA 0.67 6.82 0.35 4.47e-11 Pediatric areal bone mineral density (radius); CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg02002494 chr3:119013045 CDGAP -0.53 -6.42 -0.33 4.78e-10 Diisocyanate-induced asthma; CRC cis rs3767633 0.925 rs2499855 chr1:161929761 C/T cg09175582 chr1:161736000 ATF6 0.68 6.19 0.32 1.8e-9 IgG glycosylation; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg20822818 chr11:119235062 USP2 0.36 7.09 0.36 8.12e-12 Liver disease severity in Alagille syndrome; CRC cis rs7119 0.745 rs11632602 chr15:77809764 C/G cg10437265 chr15:77819839 NA 0.67 12.77 0.58 1.34e-30 Type 2 diabetes; CRC cis rs28386778 0.897 rs2584615 chr17:61927774 T/C cg11494091 chr17:61959527 GH2 0.59 9.97 0.48 1.2e-20 Prudent dietary pattern; CRC cis rs6964587 0.967 rs410 chr7:91557425 C/G cg17063962 chr7:91808500 NA -0.73 -12.01 -0.55 8.66e-28 Breast cancer; CRC cis rs838147 0.537 rs503279 chr19:49209010 C/T cg21064579 chr19:49206444 FUT2 -0.47 -8.21 -0.41 5.15e-15 Dietary macronutrient intake; CRC cis rs2243480 1.000 rs4718316 chr7:65648731 A/G cg12463550 chr7:65579703 CRCP -0.71 -6.52 -0.34 2.61e-10 Diabetic kidney disease; CRC cis rs11190604 1.000 rs3750630 chr10:102275780 A/G cg16342193 chr10:102329863 NA -0.34 -5.68 -0.3 2.97e-8 Palmitoleic acid (16:1n-7) levels; CRC cis rs4819052 1.000 rs13053002 chr21:46677854 C/T cg11663144 chr21:46675770 NA -0.79 -11.65 -0.54 1.69e-26 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs9486719 0.948 rs2472881 chr6:96862562 C/T cg06623918 chr6:96969491 KIAA0776 0.81 9.48 0.46 5.18e-19 Migraine;Coronary artery disease; CRC cis rs7914558 0.966 rs10748835 chr10:104660256 C/T cg15744005 chr10:104629667 AS3MT -0.32 -6.94 -0.36 2.03e-11 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg08974500 chr6:170863287 PSMB1;TBP 0.4 5.97 0.31 6.29e-9 Intelligence (multi-trait analysis); CRC cis rs1008375 0.966 rs10939755 chr4:17693755 T/C cg16339924 chr4:17578868 LAP3 0.47 6.31 0.33 8.84e-10 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs12586317 0.620 rs8021414 chr14:35581480 T/A cg05294307 chr14:35346193 BAZ1A -0.61 -7.03 -0.36 1.22e-11 Psoriasis; CRC cis rs7584330 0.554 rs76605518 chr2:238425992 G/A cg08992911 chr2:238395768 MLPH 0.47 5.74 0.3 2.21e-8 Prostate cancer; CRC cis rs6502050 0.835 rs62078305 chr17:80085326 G/A cg02741985 chr17:80059408 CCDC57 -0.44 -7.15 -0.37 5.61e-12 Life satisfaction; CRC cis rs3741151 1.000 rs74776668 chr11:73065909 G/A cg17517138 chr11:73019481 ARHGEF17 1.1 9.37 0.46 1.21e-18 GIP levels in response to oral glucose tolerance test (120 minutes); CRC cis rs41005 1.000 rs798450 chr2:8107093 C/T cg03155496 chr2:8117019 LOC339788 0.42 7.54 0.38 4.56e-13 Response to anti-TNF therapy in rheumatoid arthritis; CRC cis rs6502050 0.698 rs36043222 chr17:80117822 G/T cg09264619 chr17:80180166 NA -0.35 -5.93 -0.31 7.76e-9 Life satisfaction; CRC cis rs6502050 0.799 rs7502533 chr17:80109778 A/G cg13198984 chr17:80129470 CCDC57 0.46 8.16 0.41 6.94e-15 Life satisfaction; CRC cis rs9341808 0.667 rs3828753 chr6:80912746 C/T cg08355045 chr6:80787529 NA 0.34 5.79 0.3 1.63e-8 Sitting height ratio; CRC cis rs116095464 0.558 rs9688136 chr5:229348 T/C cg22857025 chr5:266934 NA -1.21 -16.45 -0.67 8.87e-45 Breast cancer; CRC trans rs2727020 0.615 rs10128582 chr11:49447424 C/T cg03929089 chr4:120376271 NA -0.87 -16.07 -0.66 2.73e-43 Coronary artery disease; CRC trans rs7267979 1.000 rs6050559 chr20:25329915 A/G cg17903999 chr18:56338584 MALT1 -0.42 -6.94 -0.36 2.04e-11 Liver enzyme levels (alkaline phosphatase); CRC cis rs875971 0.862 rs10224872 chr7:65759773 T/A cg12463550 chr7:65579703 CRCP -0.52 -7.37 -0.38 1.36e-12 Aortic root size; CRC cis rs2836974 0.897 rs4817996 chr21:40525759 G/C cg17971929 chr21:40555470 PSMG1 0.84 12.96 0.58 2.62e-31 Cognitive function; CRC cis rs7772486 0.875 rs9322045 chr6:146384950 C/G cg23711669 chr6:146136114 FBXO30 0.68 11.79 0.55 5.18e-27 Lobe attachment (rater-scored or self-reported); CRC cis rs561341 1.000 rs546519 chr17:30297682 T/G cg12193833 chr17:30244370 NA -0.62 -7.94 -0.4 3.33e-14 Hip circumference adjusted for BMI; CRC cis rs4713118 0.868 rs10484401 chr6:27746590 A/T cg03623178 chr6:28175578 NA -0.71 -7.85 -0.4 6.11e-14 Parkinson's disease; CRC trans rs1005277 0.579 rs1780133 chr10:38499509 T/C cg11292332 chr7:45801988 SEPT13 -0.39 -7.1 -0.36 7.68e-12 Extrinsic epigenetic age acceleration; CRC cis rs4242434 0.757 rs4872531 chr8:22529695 A/G cg03733263 chr8:22462867 KIAA1967 -0.97 -16.28 -0.67 4.02e-44 Exploratory eye movement dysfunction in schizophrenia (cognitive search score); CRC cis rs4665809 0.590 rs72809668 chr2:26467653 C/T cg08067268 chr2:26466485 HADHB;HADHA 0.65 8.34 0.42 2e-15 Gut microbiome composition (summer); CRC cis rs11098499 0.954 rs10008459 chr4:120394231 T/C cg24375607 chr4:120327624 NA 0.49 7.62 0.39 2.77e-13 Corneal astigmatism; CRC trans rs262150 0.851 rs2730249 chr7:158767628 A/G cg21167628 chr1:45308625 PTCH2 0.38 6.52 0.34 2.66e-10 Facial morphology (factor 20); CRC cis rs9549328 0.756 rs2993291 chr13:113653846 C/T cg17524180 chr13:113633600 MCF2L -0.56 -8.9 -0.44 3.83e-17 Systolic blood pressure; CRC cis rs7107174 0.901 rs2450136 chr11:77925273 T/G cg02023728 chr11:77925099 USP35 0.55 8.66 0.43 2.13e-16 Testicular germ cell tumor; CRC cis rs7671266 0.518 rs16895984 chr4:10284727 C/T cg11266682 chr4:10021025 SLC2A9 0.3 5.61 0.3 4.21e-8 Cardiovascular disease risk factors; CRC cis rs7312933 0.703 rs10492388 chr12:42608001 T/C cg19980929 chr12:42632907 YAF2 0.44 6.57 0.34 1.95e-10 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CRC cis rs7617480 0.610 rs4955420 chr3:49208865 A/G cg07636037 chr3:49044803 WDR6 0.76 11.62 0.54 2.24e-26 Subjective well-being (multi-trait analysis);Menarche (age at onset); CRC cis rs4731207 0.596 rs1600739 chr7:124639606 A/G cg23710748 chr7:124431027 NA 0.4 6.43 0.33 4.38e-10 Cutaneous malignant melanoma; CRC cis rs1005277 0.579 rs2505240 chr10:38442419 G/T cg17219203 chr10:38645113 HSD17B7P2 -0.4 -5.68 -0.3 2.89e-8 Extrinsic epigenetic age acceleration; CRC cis rs6582630 0.502 rs7312212 chr12:38274760 T/G cg13010199 chr12:38710504 ALG10B 0.43 5.83 0.31 1.34e-8 Drug-induced liver injury (flucloxacillin); CRC cis rs12541635 0.677 rs4734892 chr8:106990088 G/C cg10147462 chr8:107024639 NA 0.59 10.0 0.48 1e-20 Age of smoking initiation; CRC cis rs9527 0.590 rs10883818 chr10:104759586 A/G cg04362960 chr10:104952993 NT5C2 0.6 8.46 0.42 9.09e-16 Arsenic metabolism; CRC cis rs7107770 0.640 rs2874374 chr11:125073691 A/G cg27629782 chr11:125073726 PKNOX2 0.49 7.19 0.37 4.37e-12 Photic sneeze reflex; CRC cis rs4604732 0.578 rs12038656 chr1:247623816 A/G cg12754571 chr1:247694271 LOC148824;OR2C3 0.4 5.61 0.3 4.26e-8 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CRC cis rs3126085 0.935 rs10749669 chr1:152177289 A/C cg09127314 chr1:152161683 NA -0.52 -6.61 -0.34 1.54e-10 Atopic dermatitis; CRC cis rs1949733 0.958 rs3103069 chr4:8509451 T/G cg13073564 chr4:8508604 NA 0.49 7.17 0.37 4.95e-12 Response to antineoplastic agents; CRC trans rs771998 0.909 rs2252526 chr12:52381230 G/T cg04286455 chr5:77803462 LHFPL2 -0.39 -6.1 -0.32 3.04e-9 Post bronchodilator FEV1/FVC ratio; CRC cis rs7208859 0.623 rs75136574 chr17:28934549 C/A cg01831904 chr17:28903510 LRRC37B2 -0.61 -6.09 -0.32 3.13e-9 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs11098499 0.604 rs12642411 chr4:120580525 T/C cg24375607 chr4:120327624 NA 0.51 7.75 0.39 1.12e-13 Corneal astigmatism; CRC cis rs9372498 0.505 rs9481789 chr6:118734320 A/C cg22561889 chr6:118971681 C6orf204 0.53 6.83 0.35 4.16e-11 Diastolic blood pressure; CRC cis rs6762477 0.748 rs3755831 chr3:50228767 G/T cg05623727 chr3:50126028 RBM5 -0.41 -6.89 -0.36 2.81e-11 Menarche (age at onset); CRC cis rs67478160 0.571 rs1155751 chr14:104286547 C/G cg01849466 chr14:104193079 ZFYVE21 -0.46 -7.98 -0.4 2.45e-14 Schizophrenia; CRC cis rs514406 0.861 rs554760 chr1:53266749 G/A cg24675658 chr1:53192096 ZYG11B 0.56 8.11 0.41 1.04e-14 Monocyte count; CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg13009927 chr2:242254519 SEPT2;HDLBP 0.38 6.04 0.32 4.27e-9 Obesity-related traits; CRC cis rs425277 0.606 rs2459984 chr1:2086312 A/G cg12639453 chr1:2035780 PRKCZ 0.33 6.39 0.33 5.54e-10 Height; CRC cis rs7552404 0.731 rs7523573 chr1:76372020 G/T cg22875332 chr1:76189707 ACADM 0.64 7.84 0.4 6.51e-14 Blood metabolite levels;Acylcarnitine levels; CRC cis rs1003719 0.708 rs3787788 chr21:38502804 G/A cg10648535 chr21:38446584 PIGP;TTC3 -0.48 -6.7 -0.35 8.99e-11 Eye color traits; CRC trans rs9929218 0.861 rs3114409 chr16:68732049 A/C cg04657470 chr2:198365150 HSPE1;HSPD1 -0.99 -14.75 -0.63 3.94e-38 Colorectal cancer; CRC cis rs7937682 0.737 rs682239 chr11:111425105 A/G cg09085632 chr11:111637200 PPP2R1B 0.74 12.32 0.56 5.91e-29 Primary sclerosing cholangitis; CRC cis rs13108904 0.934 rs13134106 chr4:1302902 A/G cg02018176 chr4:1364513 KIAA1530 0.46 7.47 0.38 7.22e-13 Obesity-related traits; CRC cis rs9381040 0.655 rs2268190 chr6:41030226 C/T cg25110423 chr6:41068646 NFYA;LOC221442 -0.39 -5.91 -0.31 8.46e-9 Alzheimer's disease (late onset); CRC cis rs79387448 1.000 rs79387448 chr2:103215410 C/T cg09003973 chr2:102972529 NA 0.66 6.59 0.34 1.76e-10 Gut microbiota (bacterial taxa); CRC cis rs1552244 0.935 rs7618815 chr3:10151045 A/G cg08888203 chr3:10149979 C3orf24 0.71 9.52 0.46 3.79e-19 Alzheimer's disease; CRC cis rs2404602 0.503 rs284909 chr15:76736628 C/T cg00316803 chr15:76480434 C15orf27 -0.34 -5.69 -0.3 2.75e-8 Blood metabolite levels; CRC cis rs950169 0.922 rs11630507 chr15:85095725 A/G cg24253500 chr15:84953950 NA 0.35 5.95 0.31 6.74e-9 Schizophrenia; CRC trans rs7937682 0.889 rs497111 chr11:111499512 G/A cg18187862 chr3:45730750 SACM1L 0.47 6.77 0.35 6.1e-11 Primary sclerosing cholangitis; CRC cis rs4332037 0.802 rs12113633 chr7:1932936 G/A cg24505167 chr7:1915268 MAD1L1 -0.43 -6.06 -0.32 3.69e-9 Bipolar disorder; CRC cis rs2952156 0.920 rs12150298 chr17:37834541 T/C cg20243544 chr17:37824526 PNMT 0.55 8.95 0.44 2.66e-17 Asthma; CRC cis rs9326248 0.954 rs4938349 chr11:117021923 C/T cg15534755 chr11:117069859 TAGLN 0.34 6.48 0.34 3.29e-10 Blood protein levels; CRC cis rs7849270 0.959 rs10988233 chr9:131915926 C/A cg13538475 chr9:131942899 NA -0.3 -5.87 -0.31 1.04e-8 Blood metabolite ratios; CRC trans rs3733585 0.673 rs10000983 chr4:9951606 T/C cg26043149 chr18:55253948 FECH -0.46 -6.95 -0.36 1.96e-11 Cleft plate (environmental tobacco smoke interaction); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg12128893 chr10:75255807 PPP3CB 0.47 6.83 0.35 4.09e-11 Response to antipsychotic treatment; CRC cis rs2795502 0.882 rs2744093 chr10:43339243 A/G cg20628663 chr10:43360327 NA -0.69 -10.81 -0.51 1.67e-23 Blood protein levels; CRC trans rs1814175 0.817 rs10769618 chr11:49822336 A/G cg21153622 chr11:89784906 NA -0.37 -5.97 -0.31 6.15e-9 Height; CRC cis rs1568889 1.000 rs12790932 chr11:28046189 G/T cg06544937 chr11:28130018 METT5D1;KIF18A 0.78 11.23 0.53 5.6e-25 Bipolar disorder; CRC cis rs7447593 0.666 rs10866705 chr5:176801131 G/T cg17509989 chr5:176798049 RGS14 -0.71 -12.02 -0.55 7.57e-28 Urinary electrolytes (magnesium/calcium ratio); CRC cis rs9372498 0.536 rs2356501 chr6:118942371 C/A cg07617317 chr6:118971624 C6orf204 0.47 5.68 0.3 2.91e-8 Diastolic blood pressure; CRC cis rs7703744 0.634 rs6884061 chr5:118683431 C/T cg07086380 chr5:118691033 TNFAIP8 0.4 5.75 0.3 2e-8 Lobe attachment (rater-scored or self-reported); CRC cis rs10193935 0.901 rs10200353 chr2:42509554 A/G cg27598129 chr2:42591480 NA -0.71 -8.02 -0.4 1.83e-14 Colonoscopy-negative controls vs population controls; CRC cis rs728616 0.867 rs1923534 chr10:81710485 A/G cg11900509 chr10:81946545 ANXA11 -0.66 -6.6 -0.34 1.67e-10 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs10499694 0.868 rs1470749 chr7:50578023 G/T cg14593290 chr7:50529359 DDC -0.44 -6.35 -0.33 7e-10 Body mass index; CRC cis rs6502050 0.835 rs6502059 chr17:80082886 T/C cg02741985 chr17:80059408 CCDC57 -0.44 -7.15 -0.37 5.61e-12 Life satisfaction; CRC cis rs4129767 0.647 rs1976703 chr17:76401328 C/T cg05887092 chr17:76393375 PGS1 0.64 12.66 0.57 3.37e-30 HDL cholesterol; CRC cis rs6952808 0.595 rs3800917 chr7:2167939 A/G cg22963979 chr7:1858916 MAD1L1 0.45 6.44 0.33 4.32e-10 Bipolar disorder and schizophrenia; CRC cis rs1552244 1.000 rs7622963 chr3:10139825 C/T cg02579736 chr3:10068473 FANCD2;CIDECP 0.92 12.66 0.57 3.43e-30 Alzheimer's disease; CRC cis rs17345786 0.906 rs72944107 chr3:101197190 C/T cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.58 6.83 0.35 4e-11 Colonoscopy-negative controls vs population controls; CRC cis rs9858542 0.903 rs9875617 chr3:49634696 G/A cg03060546 chr3:49711283 APEH -0.47 -6.45 -0.34 3.99e-10 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs73206853 0.841 rs56017652 chr12:110931054 C/T cg12870014 chr12:110450643 ANKRD13A 0.75 8.1 0.41 1.08e-14 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC cis rs76878669 0.561 rs6591217 chr11:66174653 G/A cg18002602 chr11:66138449 SLC29A2 -0.29 -6.08 -0.32 3.3e-9 Educational attainment (years of education); CRC cis rs1322512 0.917 rs2758778 chr6:153007802 T/C cg03415253 chr6:152958462 SYNE1 0.4 6.04 0.32 4.14e-9 Tonometry; CRC cis rs76878669 0.561 rs4930363 chr11:66169676 C/T cg24851651 chr11:66362959 CCS -0.38 -6.57 -0.34 1.92e-10 Educational attainment (years of education); CRC cis rs6912958 1.000 rs2207144 chr6:88150816 A/G cg08069147 chr6:88032118 GJB7;C6orf162 -0.63 -9.6 -0.47 2.14e-19 Monocyte percentage of white cells; CRC cis rs9486719 1.000 rs11756315 chr6:97008678 A/G cg18709589 chr6:96969512 KIAA0776 0.5 5.8 0.3 1.53e-8 Migraine;Coronary artery disease; CRC cis rs7772486 0.875 rs10457792 chr6:146412415 T/C cg13319975 chr6:146136371 FBXO30 -0.39 -5.97 -0.31 6.03e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs1799949 0.929 rs12937015 chr17:41307473 A/C cg25072359 chr17:41440525 NA 0.46 7.0 0.36 1.42e-11 Menopause (age at onset); CRC trans rs4263408 0.934 rs9683743 chr4:39703194 A/C cg01044127 chr13:77566253 CLN5 -0.43 -6.17 -0.32 2.05e-9 Plasma amyloid beta peptide concentrations (ABx-40); CRC cis rs9491140 0.539 rs11154226 chr6:124681785 G/A cg05308643 chr6:124982296 NKAIN2 0.45 5.91 0.31 8.78e-9 Neuroticism; CRC cis rs875971 1.000 rs709595 chr7:65817333 G/C cg18912574 chr7:65842487 NCRNA00174 0.36 6.28 0.33 1.06e-9 Aortic root size; CRC trans rs12478296 1.000 rs6732595 chr2:243035338 T/C cg06834434 chr14:75079333 LTBP2 0.55 6.55 0.34 2.28e-10 Obesity-related traits; CRC cis rs637571 0.522 rs12797319 chr11:65735672 G/A cg02427764 chr11:65769310 BANF1;EIF1AD 0.41 5.71 0.3 2.59e-8 Eosinophil percentage of white cells; CRC cis rs6912958 0.500 rs9342104 chr6:87798512 A/G cg12350822 chr6:88032061 C6orf162;GJB7 -0.4 -7.46 -0.38 7.66e-13 Monocyte percentage of white cells; CRC cis rs7613875 0.600 rs2624832 chr3:50030858 C/T cg24308560 chr3:49941425 MST1R -0.44 -6.81 -0.35 4.6e-11 Body mass index; CRC cis rs28386778 0.897 rs2597634 chr17:61878144 G/A cg23090583 chr17:61904693 PSMC5;FTSJ3 1.05 20.15 0.74 2.13e-59 Prudent dietary pattern; CRC cis rs28386778 0.897 rs8067102 chr17:61848779 C/G cg11494091 chr17:61959527 GH2 0.63 10.73 0.51 3.01e-23 Prudent dietary pattern; CRC cis rs3540 0.597 rs4932346 chr15:91048991 T/C cg22089800 chr15:90895588 ZNF774 -0.56 -9.35 -0.46 1.43e-18 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; CRC cis rs7552404 0.889 rs380075 chr1:76106961 T/A cg03433033 chr1:76189801 ACADM -0.81 -11.14 -0.52 1.12e-24 Blood metabolite levels;Acylcarnitine levels; CRC cis rs600806 0.850 rs3931560 chr1:109966718 A/C cg23032129 chr1:109941072 SORT1 -0.29 -6.08 -0.32 3.28e-9 Intelligence (multi-trait analysis); CRC cis rs72781680 1.000 rs61739076 chr2:24149439 G/A cg08917208 chr2:24149416 ATAD2B 1.03 10.1 0.49 4.66e-21 Lymphocyte counts; CRC cis rs10751667 0.666 rs7123912 chr11:963936 T/C cg06064525 chr11:970664 AP2A2 -0.3 -6.11 -0.32 2.78e-9 Alzheimer's disease (late onset); CRC cis rs7091068 0.616 rs1890657 chr10:95506087 G/A cg20715218 chr10:95462985 C10orf4 0.55 5.74 0.3 2.19e-8 Urinary tract infection frequency; CRC cis rs1969363 0.509 rs8189633 chr12:38065155 C/G cg13010199 chr12:38710504 ALG10B 0.44 5.64 0.3 3.74e-8 Morning vs. evening chronotype; CRC cis rs4713118 0.629 rs149899 chr6:28019979 C/T cg12172441 chr6:28176163 NA 0.54 6.99 0.36 1.58e-11 Parkinson's disease; CRC cis rs10883723 0.810 rs2296585 chr10:104245549 C/T cg04362960 chr10:104952993 NT5C2 -0.41 -5.65 -0.3 3.48e-8 Allergic disease (asthma, hay fever or eczema); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg08748207 chr12:46777589 NA 0.44 6.13 0.32 2.46e-9 Response to antipsychotic treatment; CRC cis rs11148252 0.574 rs9536247 chr13:53279542 T/C cg02158880 chr13:53174818 NA 0.58 9.24 0.45 3.06e-18 Lewy body disease; CRC cis rs244731 1.000 rs244730 chr5:176539212 A/G cg16006841 chr5:176797999 RGS14 -0.56 -7.86 -0.4 5.4e-14 Urate levels in lean individuals; CRC cis rs9916302 0.706 rs8069074 chr17:37685401 C/T cg15445000 chr17:37608096 MED1 -0.37 -6.53 -0.34 2.49e-10 Glomerular filtration rate (creatinine); CRC cis rs3096299 0.642 rs12934829 chr16:89523349 T/A cg00750074 chr16:89608354 SPG7 -0.51 -7.76 -0.39 1.1e-13 Multiple myeloma (IgH translocation); CRC cis rs12142240 0.698 rs7515284 chr1:46809419 A/G cg14993813 chr1:46806288 NSUN4 -0.49 -6.22 -0.32 1.5e-9 Menopause (age at onset); CRC cis rs951366 0.789 rs823094 chr1:205689807 G/T cg11965913 chr1:205819406 PM20D1 -0.81 -13.65 -0.6 6.41e-34 Menarche (age at onset); CRC cis rs4713118 0.615 rs57252182 chr6:27720249 C/A cg21251018 chr6:28226885 NKAPL 0.4 6.28 0.33 1.08e-9 Parkinson's disease; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg01653354 chr6:74230425 EEF1A1 0.44 5.99 0.31 5.36e-9 Response to antipsychotic treatment; CRC cis rs875971 0.964 rs6945019 chr7:65922458 C/G cg18912574 chr7:65842487 NCRNA00174 0.36 6.14 0.32 2.41e-9 Aortic root size; CRC cis rs17209837 0.607 rs12539936 chr7:87110017 A/G cg00919237 chr7:87102261 ABCB4 0.56 7.34 0.38 1.68e-12 Gallbladder cancer; CRC cis rs10221833 0.636 rs355890 chr2:165634976 T/G cg03182029 chr2:165697222 COBLL1 0.52 6.09 0.32 3.22e-9 Response to statin therapy; CRC trans rs6550704 0.687 rs9865314 chr3:22634337 A/G cg19528231 chr10:74451771 CCDC109A -0.44 -6.4 -0.33 5.2e-10 Daytime sleep phenotypes; CRC cis rs2859741 0.935 rs2782410 chr1:37509489 G/C cg09363841 chr1:37513479 NA -0.63 -11.56 -0.54 3.75e-26 Forced expiratory volume in 1 second (environmental tobacco smoke interaction); CRC cis rs12142240 0.738 rs67545510 chr1:46806242 G/T cg00530320 chr1:46809349 NSUN4 0.57 7.8 0.39 8.39e-14 Menopause (age at onset); CRC trans rs10982213 0.830 rs2274163 chr9:117188714 C/T cg20566942 chr11:28129866 METT5D1;KIF18A 0.38 5.99 0.31 5.64e-9 Interleukin-6 levels; CRC cis rs568617 0.953 rs658524 chr11:65647260 A/G cg19792802 chr11:65647270 CTSW -0.5 -7.55 -0.38 4.23e-13 Crohn's disease; CRC cis rs6860806 1.000 rs6860806 chr5:131640536 C/T cg02033258 chr5:131593261 PDLIM4 -0.33 -6.27 -0.33 1.11e-9 Breast cancer; CRC cis rs4713118 0.515 rs9368549 chr6:28050047 T/A cg02631126 chr6:28058918 ZSCAN12L1 0.29 5.95 0.31 7.04e-9 Parkinson's disease; CRC cis rs3736485 0.966 rs4775961 chr15:51892959 A/G cg08986416 chr15:51914746 DMXL2 -0.48 -6.74 -0.35 7.06e-11 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs10197940 0.662 rs10175134 chr2:152299355 G/A cg06191203 chr2:152266755 RIF1 -0.7 -10.15 -0.49 3.09e-21 Lung cancer; CRC cis rs3785574 0.924 rs2727292 chr17:61893747 A/G cg23090583 chr17:61904693 PSMC5;FTSJ3 0.65 9.26 0.45 2.71e-18 Height; CRC cis rs4975616 0.839 rs2447853 chr5:1333077 A/G cg06550200 chr5:1325588 CLPTM1L -0.73 -11.56 -0.54 3.63e-26 Lung cancer; CRC cis rs1046896 0.553 rs8073413 chr17:80836005 G/A cg08200770 chr17:80723486 TBCD -0.5 -7.61 -0.39 2.97e-13 Glycated hemoglobin levels; CRC cis rs919433 0.750 rs788010 chr2:198230949 T/C cg03934865 chr2:198174659 NA 0.36 5.82 0.31 1.42e-8 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC cis rs9976767 0.637 rs9984108 chr21:43825628 T/G cg23042151 chr21:43824109 UBASH3A -0.43 -7.53 -0.38 5.08e-13 Type 1 diabetes; CRC cis rs6840360 0.642 rs4263379 chr4:152399131 G/A cg09659197 chr4:152720779 NA 0.34 6.64 0.34 1.32e-10 Intelligence (multi-trait analysis); CRC cis rs9311474 0.713 rs352169 chr3:52236762 C/T cg18099408 chr3:52552593 STAB1 -0.35 -5.67 -0.3 3.09e-8 Electroencephalogram traits; CRC cis rs7044106 0.762 rs10760112 chr9:123467570 C/T cg09586646 chr9:123605570 PSMD5;LOC253039 0.59 8.74 0.43 1.23e-16 Hip circumference adjusted for BMI; CRC cis rs951366 0.559 rs823101 chr1:205667006 T/C cg11965913 chr1:205819406 PM20D1 0.77 11.4 0.53 1.33e-25 Menarche (age at onset); CRC cis rs11628318 0.614 rs7143048 chr14:103119800 C/T cg23461800 chr14:103021989 NA 0.69 7.84 0.4 6.5e-14 Platelet count; CRC cis rs4363385 0.747 rs3753454 chr1:152973776 T/C cg25856811 chr1:152973957 SPRR3 -0.27 -7.36 -0.38 1.45e-12 Inflammatory skin disease; CRC cis rs775227 0.574 rs34286076 chr3:113269695 G/C cg18753928 chr3:113234510 CCDC52 -0.59 -6.98 -0.36 1.59e-11 Dental caries; CRC cis rs597539 0.652 rs488363 chr11:68658298 C/G cg21963583 chr11:68658836 MRPL21 0.63 11.52 0.54 5.02e-26 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs174601 0.861 rs174550 chr11:61571478 T/C cg00603274 chr11:61596626 FADS2 -0.44 -6.4 -0.33 5.33e-10 Blood metabolite levels;Red blood cell fatty acid levels;Liver enzyme levels (alkaline phosphatase);Gondoic acid (20:1n-9) levels;Trans fatty acid levels; CRC trans rs2303319 0.504 rs62188147 chr2:162286552 G/T cg19471553 chr17:41393123 NA -0.68 -6.05 -0.32 4e-9 Cognitive function; CRC cis rs2075371 1.000 rs2598285 chr7:133971153 A/T cg02659138 chr7:134003124 SLC35B4 0.36 6.31 0.33 8.99e-10 Mean platelet volume; CRC trans rs1005277 0.579 rs2474595 chr10:38426782 C/G cg17830980 chr10:43048298 ZNF37B 0.6 9.82 0.48 3.86e-20 Extrinsic epigenetic age acceleration; CRC cis rs2239547 0.563 rs9876403 chr3:52916916 C/T cg11645453 chr3:52864694 ITIH4 0.52 9.2 0.45 4.34e-18 Schizophrenia; CRC cis rs881375 0.934 rs2159778 chr9:123678129 G/A cg09586646 chr9:123605570 PSMD5;LOC253039 0.55 7.92 0.4 3.76e-14 Rheumatoid arthritis; CRC cis rs4332037 0.539 rs34571717 chr7:2106855 T/C cg14004847 chr7:1930337 MAD1L1 -0.43 -5.72 -0.3 2.42e-8 Bipolar disorder; CRC cis rs7523050 0.730 rs67312582 chr1:109423976 A/G cg08274380 chr1:109419600 GPSM2 0.89 7.75 0.39 1.18e-13 Fat distribution (HIV); CRC cis rs4964805 0.586 rs934846 chr12:104185297 C/T cg02344784 chr12:104178138 NT5DC3 0.81 16.03 0.66 4e-43 Attention deficit hyperactivity disorder; CRC cis rs861020 0.630 rs686582 chr1:210008673 A/C cg09163369 chr1:210001066 C1orf107 0.42 6.2 0.32 1.73e-9 Orofacial clefts; CRC cis rs780096 0.506 rs56076827 chr2:27676287 A/T cg02592271 chr2:27665507 KRTCAP3 -0.27 -5.94 -0.31 7.17e-9 Total body bone mineral density; CRC cis rs9341808 0.591 rs6454147 chr6:80916328 G/A cg08355045 chr6:80787529 NA 0.38 6.34 0.33 7.63e-10 Sitting height ratio; CRC cis rs539514 0.612 rs9573648 chr13:76309279 A/G cg04757411 chr13:76259545 LMO7 -0.35 -5.95 -0.31 6.79e-9 Type 1 diabetes; CRC cis rs8077889 0.917 rs60335331 chr17:41907509 A/G cg26893861 chr17:41843967 DUSP3 0.9 13.04 0.58 1.29e-31 Triglycerides; CRC cis rs9304742 0.888 rs8112137 chr19:53457255 T/C cg09915433 chr19:53449742 NA -0.6 -8.96 -0.44 2.5e-17 Psoriasis; CRC cis rs62229266 0.625 rs2051395 chr21:37431265 A/C cg12218747 chr21:37451666 NA 0.33 5.7 0.3 2.73e-8 Mitral valve prolapse; CRC cis rs200986 1 rs200986 chr6:27824766 G/C cg25164649 chr6:28176230 NA 0.59 8.33 0.42 2.26e-15 Autism spectrum disorder or schizophrenia; CRC cis rs11971779 0.715 rs10085527 chr7:139064360 G/A cg07862535 chr7:139043722 LUC7L2 0.59 7.58 0.39 3.58e-13 Diisocyanate-induced asthma; CRC cis rs6840360 1.000 rs6535814 chr4:152609694 A/G cg09659197 chr4:152720779 NA 0.5 10.71 0.51 3.59e-23 Intelligence (multi-trait analysis); CRC trans rs1455244 0.700 rs7229302 chr18:11508904 G/T cg26655295 chr2:677162 TMEM18 0.42 6.32 0.33 8.3e-10 Schizophrenia; CRC cis rs67311347 0.955 rs60554147 chr3:40472503 T/C cg24209194 chr3:40518798 ZNF619 0.42 6.33 0.33 8.25e-10 Renal cell carcinoma; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg01744215 chr16:9056616 USP7 0.48 6.49 0.34 3.14e-10 Anxiety disorder; CRC cis rs2880765 0.527 rs1483578 chr15:86075417 A/G cg10818794 chr15:86012489 AKAP13 -0.45 -6.49 -0.34 3.1e-10 Coronary artery disease; CRC cis rs1552244 0.832 rs66597916 chr3:10195407 T/C cg10729496 chr3:10149963 C3orf24 0.61 7.18 0.37 4.55e-12 Alzheimer's disease; CRC cis rs9910055 0.529 rs170637 chr17:42186868 C/T cg19774624 chr17:42201019 HDAC5 0.54 7.25 0.37 3.01e-12 Total body bone mineral density; CRC cis rs6952808 0.723 rs57216949 chr7:2030287 G/T cg02951883 chr7:2050386 MAD1L1 -0.79 -12.86 -0.58 6.21e-31 Bipolar disorder and schizophrenia; CRC cis rs8141529 0.732 rs6005881 chr22:29183133 A/G cg15103426 chr22:29168792 CCDC117 0.57 8.26 0.41 3.58e-15 Lymphocyte counts; CRC cis rs9393692 0.557 rs62394764 chr6:26305503 T/C cg13736514 chr6:26305472 NA -0.45 -7.28 -0.37 2.43e-12 Educational attainment; CRC cis rs73206853 0.841 rs7967246 chr12:110756569 G/A cg12870014 chr12:110450643 ANKRD13A 0.84 8.88 0.44 4.54e-17 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg27274463 chr12:110338238 TCHP 0.39 6.14 0.32 2.36e-9 Intelligence (multi-trait analysis); CRC cis rs10504229 1.000 rs59071610 chr8:58186301 A/C cg02725872 chr8:58115012 NA -0.38 -6.36 -0.33 6.56e-10 Developmental language disorder (linguistic errors); CRC cis rs9462027 0.607 rs205259 chr6:34564066 A/G cg07306190 chr6:34760872 UHRF1BP1 -0.34 -5.98 -0.31 5.86e-9 Systemic lupus erythematosus; CRC cis rs4132462 0.924 rs6749448 chr2:212607990 C/T cg15635483 chr2:212618994 ERBB4 0.41 6.03 0.32 4.5e-9 Intelligence (multi-trait analysis); CRC cis rs4713118 0.662 rs9468271 chr6:28024570 A/G cg25164649 chr6:28176230 NA 0.66 8.76 0.43 1.08e-16 Parkinson's disease; CRC cis rs68170813 0.641 rs79434636 chr7:107105656 A/C cg02696742 chr7:106810147 HBP1 -0.56 -5.91 -0.31 8.79e-9 Coronary artery disease; CRC cis rs2243480 1.000 rs313799 chr7:65494330 A/G cg18252515 chr7:66147081 NA -1.09 -12.2 -0.56 1.65e-28 Diabetic kidney disease; CRC cis rs17433780 0.857 rs12144445 chr1:89465238 C/T cg09516651 chr1:89888402 LOC400759 0.46 6.78 0.35 5.55e-11 Carotid intima media thickness; CRC cis rs2717559 0.542 rs2717586 chr8:143897882 C/T cg12516270 chr8:143859308 LYNX1 0.67 12.03 0.55 7.18e-28 Urinary tract infection frequency; CRC cis rs7937682 0.921 rs11213940 chr11:111433927 C/A cg09085632 chr11:111637200 PPP2R1B 0.94 15.0 0.64 3.89e-39 Primary sclerosing cholangitis; CRC trans rs6544773 0.668 rs572753 chr2:45072029 T/G cg10208897 chr5:178548229 ADAMTS2 0.35 5.97 0.31 6.17e-9 Mosquito bite size; CRC cis rs1983170 1.000 rs10874785 chr1:92015243 G/A cg25838465 chr1:92012736 NA 0.42 5.72 0.3 2.37e-8 Eosinophil percentage of white cells; CRC cis rs34526934 0.608 rs34720456 chr2:177027292 G/A cg14324370 chr2:177042789 NA -0.69 -9.35 -0.46 1.34e-18 Obstructive sleep apnea trait (apnea hypopnea index); CRC cis rs9807989 0.507 rs6710034 chr2:103023678 G/A cg03938978 chr2:103052716 IL18RAP 0.59 10.17 0.49 2.68e-21 Asthma; CRC cis rs9868809 0.772 rs12107418 chr3:48689787 A/G cg07636037 chr3:49044803 WDR6 -0.66 -7.01 -0.36 1.35e-11 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; CRC trans rs17685 0.884 rs6978677 chr7:75636240 C/T cg19862616 chr7:65841803 NCRNA00174 0.8 11.31 0.53 2.79e-25 Coffee consumption;Coffee consumption (cups per day); CRC trans rs877282 0.891 rs12767043 chr10:797943 C/T cg22713356 chr15:30763199 NA 1.34 16.86 0.68 2.17e-46 Uric acid levels; CRC cis rs57502260 0.573 rs11228294 chr11:68388567 C/T cg16797656 chr11:68205561 LRP5 0.46 6.53 0.34 2.44e-10 Total body bone mineral density (age 45-60); CRC cis rs11758351 0.789 rs2069020 chr6:26205500 C/T cg10723962 chr6:26240782 HIST1H4F -0.38 -6.03 -0.32 4.32e-9 Gout;Renal underexcretion gout; CRC cis rs11229555 0.645 rs11229430 chr11:58181104 G/C cg15696309 chr11:58395628 NA -0.81 -10.31 -0.49 8.83e-22 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; CRC cis rs10504229 1.000 rs60231757 chr8:58169937 T/C cg02290350 chr8:58132656 NA -0.42 -5.96 -0.31 6.62e-9 Developmental language disorder (linguistic errors); CRC cis rs3736485 0.844 rs55981933 chr15:51785436 C/G cg08986416 chr15:51914746 DMXL2 -0.46 -6.66 -0.34 1.14e-10 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs13108904 0.901 rs12641735 chr4:1304434 G/C cg20092199 chr4:1342459 KIAA1530 0.37 6.5 0.34 2.89e-10 Obesity-related traits; CRC cis rs4268898 0.662 rs2288074 chr2:24413595 C/T cg06627628 chr2:24431161 ITSN2 -0.85 -11.54 -0.54 4.29e-26 Asthma; CRC cis rs6860806 0.507 rs274570 chr5:131713226 C/T cg04518342 chr5:131593106 PDLIM4 -0.43 -7.03 -0.36 1.18e-11 Breast cancer; CRC cis rs7615952 0.576 rs1127717 chr3:125826059 T/C cg18479299 chr3:125709523 NA -0.47 -5.64 -0.3 3.58e-8 Blood pressure (smoking interaction); CRC cis rs769267 0.930 rs10282 chr19:19619317 T/C cg03709012 chr19:19516395 GATAD2A 0.72 11.21 0.53 6.56e-25 Tonsillectomy; CRC cis rs490234 0.812 rs13300639 chr9:128407298 A/G cg14078157 chr9:128172775 NA -0.42 -7.14 -0.37 6.07e-12 Mean arterial pressure; CRC cis rs11608355 0.545 rs4766603 chr12:109892106 T/C cg05360138 chr12:110035743 NA 0.77 8.7 0.43 1.65e-16 Neuroticism; CRC cis rs17376456 0.825 rs17314762 chr5:93231200 C/T cg25358565 chr5:93447407 FAM172A 1.06 10.21 0.49 1.86e-21 Diabetic retinopathy; CRC cis rs611744 0.647 rs11774904 chr8:109273435 G/A cg21045802 chr8:109455806 TTC35 0.43 6.86 0.35 3.42e-11 Dupuytren's disease; CRC cis rs10504229 0.609 rs66477547 chr8:58105763 A/C cg02290350 chr8:58132656 NA -0.58 -7.89 -0.4 4.38e-14 Developmental language disorder (linguistic errors); CRC cis rs11148252 0.595 rs4885325 chr13:53171317 C/T cg12458913 chr13:53173898 NA 0.75 13.79 0.61 1.85e-34 Lewy body disease; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg00692763 chr18:47088373 LIPG 0.46 6.65 0.34 1.19e-10 Response to antipsychotic treatment; CRC cis rs9303280 0.901 rs2290400 chr17:38066240 A/G cg00129232 chr17:37814104 STARD3 -0.42 -6.43 -0.33 4.49e-10 Self-reported allergy; CRC cis rs875971 1.000 rs6956179 chr7:65806659 C/T cg00343986 chr7:65444356 GUSB -0.4 -5.88 -0.31 9.81e-9 Aortic root size; CRC cis rs9303401 0.614 rs35245220 chr17:56510305 G/A cg02118635 chr17:56770003 RAD51C;TEX14 0.78 9.14 0.45 6.45e-18 Cognitive test performance; CRC cis rs6951245 0.935 rs61910751 chr7:1097895 A/G cg20603222 chr7:1096387 C7orf50;GPR146 -0.72 -8.66 -0.43 2.19e-16 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs1215050 0.791 rs783950 chr4:98878395 C/T cg05340658 chr4:99064831 C4orf37 -0.5 -7.57 -0.39 3.87e-13 Waist-to-hip ratio adjusted for body mass index; CRC cis rs12681287 0.577 rs10481197 chr8:87546551 A/T cg27223183 chr8:87520930 FAM82B 0.5 6.7 0.35 9.05e-11 Caudate activity during reward; CRC cis rs10193935 1.000 rs12618105 chr2:42414146 T/G cg27598129 chr2:42591480 NA -0.71 -8.3 -0.42 2.69e-15 Colonoscopy-negative controls vs population controls; CRC cis rs6867032 0.527 rs4246752 chr5:1975575 T/A cg26168224 chr5:2018326 NA -0.8 -11.39 -0.53 1.51e-25 Gut microbiome composition (winter); CRC cis rs6500395 1.000 rs6500397 chr16:48642235 T/C cg04672837 chr16:48644449 N4BP1 0.45 6.44 0.33 4.15e-10 Response to tocilizumab in rheumatoid arthritis; CRC cis rs9914988 0.943 rs4794839 chr17:27131393 G/A cg07195577 chr17:27052828 TLCD1 0.42 6.02 0.32 4.64e-9 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC trans rs1005277 0.579 rs1985707 chr10:38434098 C/T cg11292332 chr7:45801988 SEPT13 -0.35 -6.24 -0.33 1.38e-9 Extrinsic epigenetic age acceleration; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg19819135 chr1:70710422 SFRS11 -0.4 -6.74 -0.35 6.94e-11 Liver disease severity in Alagille syndrome; CRC cis rs765787 0.530 rs2413784 chr15:45530516 A/C cg24006582 chr15:45444508 DUOX1 -0.58 -8.85 -0.44 5.42e-17 Uric acid levels; CRC cis rs12477438 0.798 rs13393860 chr2:99590397 C/T cg26064155 chr2:99771622 LIPT1;TSGA10 -0.75 -10.56 -0.5 1.23e-22 Chronic sinus infection; CRC cis rs7811142 1.000 rs67315960 chr7:100015124 A/G cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.99 13.56 0.6 1.37e-33 Platelet count; CRC cis rs514406 0.679 rs61768344 chr1:53229274 G/A cg24675658 chr1:53192096 ZYG11B 0.78 12.05 0.55 5.95e-28 Monocyte count; CRC cis rs8060686 0.516 rs1971546 chr16:68280893 T/C cg26727032 chr16:67993705 SLC12A4 -0.64 -9.23 -0.45 3.34e-18 HDL cholesterol;Metabolic syndrome; CRC cis rs9303280 0.901 rs12936231 chr17:38029120 C/G cg11212589 chr17:38028394 ZPBP2 0.46 8.74 0.43 1.21e-16 Self-reported allergy; CRC cis rs853679 1.000 rs735765 chr6:28170297 G/A cg15845792 chr6:28175446 NA 0.82 7.87 0.4 5.26e-14 Depression; CRC cis rs55823223 0.680 rs57287238 chr17:73850940 T/C cg14829360 chr17:73884958 NA -0.46 -6.95 -0.36 2.03e-11 Psoriasis; CRC trans rs3960554 0.867 rs76408713 chr7:75829540 G/A cg19862616 chr7:65841803 NCRNA00174 0.73 8.29 0.42 2.83e-15 Eotaxin levels; CRC cis rs524023 1.000 rs505802 chr11:64357072 T/C cg06522879 chr11:64358276 SLC22A12 0.57 8.83 0.44 6.21e-17 Urate levels in obese individuals; CRC cis rs425277 0.958 rs262652 chr1:2090816 T/C cg24578937 chr1:2090814 PRKCZ 0.66 11.67 0.54 1.48e-26 Height; CRC trans rs1814175 0.791 rs11040513 chr11:49778153 G/C cg11707556 chr5:10655725 ANKRD33B -0.42 -8.05 -0.41 1.5e-14 Height; CRC trans rs2303319 0.582 rs12464282 chr2:162448855 C/T cg14875682 chr5:52083620 ITGA1;PELO -0.72 -5.97 -0.31 6.06e-9 Cognitive function; CRC trans rs877282 0.891 rs34652870 chr10:772218 T/C cg22713356 chr15:30763199 NA 1.27 15.87 0.66 1.59e-42 Uric acid levels; CRC trans rs66573146 0.656 rs56094305 chr4:6956086 C/T cg07817883 chr1:32538562 TMEM39B 1.1 11.91 0.55 1.96e-27 Granulocyte percentage of myeloid white cells; CRC trans rs11671005 0.504 rs3794963 chr19:59071051 C/G cg22037779 chr5:139682734 PFDN1 0.58 8.33 0.42 2.17e-15 Mean platelet volume; CRC cis rs7647973 1.000 rs7647973 chr3:49510931 G/A cg07636037 chr3:49044803 WDR6 -0.64 -7.38 -0.38 1.26e-12 Menarche (age at onset); CRC cis rs2072499 0.966 rs2842864 chr1:156159217 G/A cg06970220 chr1:156163860 SLC25A44 0.5 7.13 0.37 6.42e-12 Testicular germ cell tumor; CRC cis rs2120019 0.935 rs12591119 chr15:75355944 A/G cg11632617 chr15:75315747 PPCDC -0.55 -7.39 -0.38 1.23e-12 Blood trace element (Zn levels); CRC cis rs4285028 0.747 rs9850439 chr3:121393075 T/C cg20356878 chr3:121714668 ILDR1 -0.43 -6.09 -0.32 3.08e-9 Multiple sclerosis; CRC cis rs9527 0.614 rs11191589 chr10:104930382 T/C cg04362960 chr10:104952993 NT5C2 0.61 8.4 0.42 1.37e-15 Arsenic metabolism; CRC cis rs514406 0.825 rs497535 chr1:53284677 A/G cg08859206 chr1:53392774 SCP2 0.45 6.94 0.36 2.08e-11 Monocyte count; CRC cis rs9287719 0.649 rs12617968 chr2:10721945 C/T cg00105475 chr2:10696890 NA 0.44 7.0 0.36 1.43e-11 Prostate cancer; CRC cis rs4819052 0.851 rs9754134 chr21:46661751 T/C cg02159808 chr21:46707872 POFUT2;LOC642852 0.49 6.41 0.33 5.19e-10 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs514406 0.505 rs269293 chr1:53187767 A/C cg08859206 chr1:53392774 SCP2 -0.4 -6.13 -0.32 2.45e-9 Monocyte count; CRC cis rs7692995 1.000 rs6830062 chr4:18017730 A/G cg08925142 chr4:18023851 LCORL -0.5 -5.66 -0.3 3.31e-8 Height; CRC cis rs3736485 0.934 rs2899476 chr15:51903874 C/T cg08986416 chr15:51914746 DMXL2 -0.45 -6.53 -0.34 2.56e-10 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs17270561 0.609 rs1892245 chr6:25764833 G/T cg17691542 chr6:26056736 HIST1H1C 0.64 8.14 0.41 8.02e-15 Iron status biomarkers; CRC cis rs3889199 0.924 rs12739904 chr1:59669488 T/C cg25881383 chr1:59680599 NA -0.38 -6.08 -0.32 3.36e-9 Pulse pressure; CRC cis rs11628318 0.508 rs3950014 chr14:103069889 G/A cg23461800 chr14:103021989 NA -0.68 -7.83 -0.4 6.62e-14 Platelet count; CRC cis rs6502050 0.835 rs7221451 chr17:80089785 A/G cg19223190 chr17:80058835 NA 0.41 6.43 0.33 4.51e-10 Life satisfaction; CRC cis rs12200560 0.505 rs211177 chr6:97074088 C/T cg06623918 chr6:96969491 KIAA0776 0.52 7.7 0.39 1.63e-13 Coronary heart disease; CRC cis rs501916 0.833 rs3809486 chr15:48051549 G/T cg16110827 chr15:48056943 SEMA6D -0.53 -8.08 -0.41 1.25e-14 Inflammatory bowel disease;Ulcerative colitis; CRC cis rs1552244 0.554 rs17050704 chr3:10045734 T/C cg16606324 chr3:10149918 C3orf24 0.48 7.09 0.36 8.29e-12 Alzheimer's disease; CRC cis rs1448094 0.527 rs1900700 chr12:86232166 C/T cg00310523 chr12:86230176 RASSF9 0.36 5.91 0.31 8.73e-9 Major depressive disorder; CRC trans rs4942242 0.663 rs34978818 chr13:44214096 T/C cg26741380 chr15:41871084 TYRO3 -0.5 -7.09 -0.36 8.25e-12 Response to tocilizumab in rheumatoid arthritis; CRC cis rs8141529 0.584 rs58004020 chr22:29257050 A/T cg15103426 chr22:29168792 CCDC117 0.56 8.09 0.41 1.14e-14 Lymphocyte counts; CRC cis rs11098499 0.691 rs2136911 chr4:120265859 G/A cg09307838 chr4:120376055 NA 0.62 9.69 0.47 1.07e-19 Corneal astigmatism; CRC cis rs6735179 0.532 rs6756670 chr2:1761496 A/G cg19300414 chr2:1746591 PXDN 0.36 6.26 0.33 1.19e-9 Response to antipsychotic treatment; CRC cis rs7666738 0.830 rs6854703 chr4:98977586 A/T cg05340658 chr4:99064831 C4orf37 0.57 8.76 0.43 1.05e-16 Colonoscopy-negative controls vs population controls; CRC cis rs796364 0.951 rs1105964 chr2:201000776 T/A cg12253985 chr2:200820533 C2orf60;C2orf47 -0.55 -6.12 -0.32 2.68e-9 Schizophrenia; CRC cis rs6502050 0.835 rs8065210 chr17:80090960 G/A cg02741985 chr17:80059408 CCDC57 0.43 7.11 0.36 7.33e-12 Life satisfaction; CRC cis rs853679 0.513 rs9468296 chr6:28113730 A/G cg12963246 chr6:28129442 ZNF389 0.49 5.7 0.3 2.71e-8 Depression; CRC trans rs7267979 1.000 rs6037099 chr20:25356876 T/G cg17903999 chr18:56338584 MALT1 0.42 6.94 0.36 2.1e-11 Liver enzyme levels (alkaline phosphatase); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg00706505 chr3:49142215 QARS 0.46 6.42 0.33 4.88e-10 Response to antipsychotic treatment; CRC trans rs2797160 1.000 rs1418639 chr6:125999940 C/T cg05039488 chr6:79577232 IRAK1BP1 -0.5 -7.55 -0.38 4.4e-13 Endometrial cancer; CRC cis rs9894429 0.816 rs7406040 chr17:79597583 A/C cg21984481 chr17:79567631 NPLOC4 -0.57 -10.89 -0.51 8.51e-24 Eye color traits; CRC cis rs13315871 0.929 rs6769216 chr3:58238877 C/T cg20936604 chr3:58311152 NA -0.67 -6.76 -0.35 6.41e-11 Cholesterol, total; CRC cis rs9916302 0.706 rs9890198 chr17:37457480 A/C cg00129232 chr17:37814104 STARD3 0.56 6.67 0.35 1.07e-10 Glomerular filtration rate (creatinine); CRC cis rs6502050 0.769 rs4789741 chr17:80119184 A/C cg09264619 chr17:80180166 NA -0.35 -5.81 -0.31 1.48e-8 Life satisfaction; CRC cis rs477692 0.669 rs12265939 chr10:131445398 A/G cg05714579 chr10:131428358 MGMT -0.71 -10.88 -0.51 9.56e-24 Response to temozolomide; CRC trans rs2727020 0.724 rs4109837 chr11:49372051 A/T cg15704280 chr7:45808275 SEPT13 -0.78 -10.61 -0.5 8.24e-23 Coronary artery disease; CRC cis rs8060686 0.858 rs8057986 chr16:67893879 A/G cg00318322 chr16:67708822 GFOD2 -0.31 -5.98 -0.31 5.88e-9 HDL cholesterol;Metabolic syndrome; CRC cis rs8010715 0.785 rs2877611 chr14:24595430 C/T cg23112188 chr14:24563095 PCK2 -0.37 -7.27 -0.37 2.69e-12 IgG glycosylation; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg04139749 chr14:77786727 GSTZ1;POMT2 -0.44 -6.42 -0.33 4.78e-10 Myopia (pathological); CRC trans rs875971 0.660 rs2191268 chr7:66110224 C/T cg06231882 chr16:81040594 CENPN;C16orf61 -0.42 -6.46 -0.34 3.66e-10 Aortic root size; CRC cis rs4731207 0.565 rs10227119 chr7:124593780 T/A cg23710748 chr7:124431027 NA -0.38 -6.05 -0.32 4e-9 Cutaneous malignant melanoma; CRC cis rs7044106 0.791 rs7043969 chr9:123493989 A/C cg09419670 chr9:123605666 PSMD5;LOC253039 0.77 12.95 0.58 2.91e-31 Hip circumference adjusted for BMI; CRC cis rs995000 0.931 rs11207986 chr1:63018170 T/C cg19896129 chr1:63156450 NA -0.44 -6.78 -0.35 5.74e-11 Triglyceride levels; CRC trans rs944990 0.595 rs10123378 chr9:96375217 C/T cg09080729 chr16:81069740 ATMIN 0.49 7.12 0.37 6.79e-12 Body mass index; CRC cis rs6570726 0.902 rs4895678 chr6:145935510 C/T cg05347473 chr6:146136440 FBXO30 0.4 6.07 0.32 3.61e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs747650 0.504 rs11039081 chr11:47093465 C/G cg19486271 chr11:47235900 DDB2 0.44 5.77 0.3 1.79e-8 Acne (severe); CRC trans rs1814175 0.607 rs11493324 chr11:50011304 T/C cg03929089 chr4:120376271 NA -0.76 -12.36 -0.56 4.46e-29 Height; CRC cis rs56307353 0.652 rs4807191 chr19:1990309 C/T cg05502645 chr19:1971281 CSNK1G2 -0.41 -6.46 -0.34 3.68e-10 Coronary artery disease; CRC cis rs951366 0.789 rs1772148 chr1:205704580 A/T cg17178900 chr1:205818956 PM20D1 0.67 9.7 0.47 9.69e-20 Menarche (age at onset); CRC trans rs9929218 0.953 rs12920562 chr16:68737512 C/T cg04657470 chr2:198365150 HSPE1;HSPD1 -0.91 -12.17 -0.56 2.23e-28 Colorectal cancer; CRC trans rs208520 0.526 rs9354366 chr6:66788559 C/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.16 -25.23 -0.81 6.72e-79 Exhaled nitric oxide output; CRC cis rs3015497 0.616 rs11157759 chr14:51087263 A/G cg09863266 chr14:51125203 SAV1 -0.32 -6.16 -0.32 2.11e-9 Mean platelet volume; CRC cis rs826838 0.967 rs826858 chr12:39116731 A/G cg13010199 chr12:38710504 ALG10B -0.41 -5.86 -0.31 1.1e-8 Heart rate; CRC cis rs1552244 0.572 rs67227131 chr3:10172744 G/A cg10729496 chr3:10149963 C3orf24 0.56 5.95 0.31 6.98e-9 Alzheimer's disease; CRC cis rs6499255 0.857 rs11643926 chr16:69807282 A/G cg04110750 chr16:69646130 NFAT5 -0.51 -6.68 -0.35 1.05e-10 IgE levels; CRC cis rs736801 0.569 rs12517950 chr5:131731326 A/G cg11843238 chr5:131593191 PDLIM4 0.33 5.83 0.31 1.32e-8 Breast cancer;Mosquito bite size; CRC cis rs2303759 0.874 rs10411630 chr19:49891314 C/A cg22307029 chr19:49891270 CCDC155 0.69 9.63 0.47 1.74e-19 Multiple sclerosis; CRC cis rs2816062 1.000 rs2816062 chr1:18903902 G/A cg18795169 chr1:18902165 NA -0.88 -17.12 -0.69 1.95e-47 Urate levels in lean individuals; CRC trans rs7819412 0.654 rs34741518 chr8:10776860 A/C cg06636001 chr8:8085503 FLJ10661 -0.62 -9.15 -0.45 6.04e-18 Triglycerides; CRC trans rs1728785 0.901 rs1645934 chr16:68564490 T/A cg04657470 chr2:198365150 HSPE1;HSPD1 0.57 6.78 0.35 5.72e-11 Ulcerative colitis; CRC cis rs9462027 0.583 rs6937784 chr6:34644276 T/G cg07306190 chr6:34760872 UHRF1BP1 -0.36 -6.33 -0.33 8.25e-10 Systemic lupus erythematosus; CRC cis rs875971 0.545 rs2420612 chr7:66001812 G/A cg18876405 chr7:65276391 NA 0.45 6.23 0.32 1.44e-9 Aortic root size; CRC cis rs10504229 1.000 rs116444534 chr8:58181915 A/G cg24829409 chr8:58192753 C8orf71 -0.65 -11.06 -0.52 2.26e-24 Developmental language disorder (linguistic errors); CRC cis rs11098499 0.657 rs7664458 chr4:120371967 A/G cg24375607 chr4:120327624 NA 0.51 7.98 0.4 2.49e-14 Corneal astigmatism; CRC cis rs9309711 0.666 rs11127430 chr2:3485242 G/C cg10845886 chr2:3471009 TTC15 -0.4 -6.29 -0.33 1.01e-9 Neurofibrillary tangles; CRC cis rs9291683 0.609 rs12500810 chr4:10031068 G/A cg00071950 chr4:10020882 SLC2A9 0.67 12.65 0.57 3.59e-30 Bone mineral density; CRC cis rs9409565 0.826 rs9409546 chr9:97209066 T/C cg04523069 chr9:97136363 HIATL1 0.37 5.67 0.3 3.05e-8 Colorectal cancer (alcohol consumption interaction); CRC cis rs7917772 0.636 rs2250580 chr10:104505687 C/G cg11453585 chr10:104263688 ACTR1A;SUFU 0.77 11.22 0.53 5.91e-25 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC cis rs1799949 1.000 rs12942277 chr17:41187974 G/C cg25072359 chr17:41440525 NA 0.45 6.55 0.34 2.16e-10 Menopause (age at onset); CRC cis rs12368653 0.789 rs2270777 chr12:58145156 C/T cg00677455 chr12:58241039 CTDSP2 -0.52 -7.26 -0.37 2.82e-12 Multiple sclerosis; CRC cis rs10256972 0.521 rs871019 chr7:1105230 A/G cg22907277 chr7:1156413 C7orf50 0.4 5.92 0.31 8.02e-9 Longevity;Endometriosis; CRC cis rs9733 0.596 rs6685702 chr1:150656307 A/G cg17724175 chr1:150552817 MCL1 0.58 9.4 0.46 9.25e-19 Tonsillectomy; CRC cis rs763014 1.000 rs2269558 chr16:682250 C/T cg09263875 chr16:632152 PIGQ 0.8 12.77 0.58 1.33e-30 Height; CRC cis rs7737355 0.947 rs13163091 chr5:130836041 A/G cg06307176 chr5:131281290 NA -0.44 -6.4 -0.33 5.2400000000000005e-10 Life satisfaction; CRC cis rs875971 0.545 rs1909508 chr7:65766353 G/T cg03233332 chr7:66118400 NA -0.43 -6.11 -0.32 2.75e-9 Aortic root size; CRC cis rs2731664 0.792 rs335452 chr5:176879671 C/T cg23176889 chr5:176863531 GRK6 -0.74 -16.26 -0.67 4.76e-44 Intelligence (multi-trait analysis); CRC cis rs1448094 0.621 rs10863089 chr12:86279699 C/T cg18827107 chr12:86230957 RASSF9 -0.45 -7.24 -0.37 3.29e-12 Major depressive disorder; CRC cis rs853679 0.517 rs9380055 chr6:28081629 A/G cg12172441 chr6:28176163 NA 0.62 7.27 0.37 2.56e-12 Depression; CRC cis rs2303745 0.589 rs7246262 chr19:17392483 C/G cg02221750 chr19:17393354 ANKLE1 -0.43 -6.59 -0.34 1.74e-10 Systemic lupus erythematosus; CRC trans rs916888 0.610 rs199446 chr17:44813169 G/A cg22433210 chr17:43662623 NA -0.61 -7.65 -0.39 2.26e-13 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg13824859 chr6:109804376 ZBTB24 0.46 6.56 0.34 2.12e-10 Anxiety disorder; CRC cis rs883565 0.569 rs1274969 chr3:39169712 T/C cg01426195 chr3:39028469 NA 0.4 6.64 0.34 1.29e-10 Handedness; CRC cis rs713477 1.000 rs8014621 chr14:55906849 A/C cg13175173 chr14:55914753 NA -0.46 -8.39 -0.42 1.48e-15 Pediatric bone mineral content (femoral neck); CRC cis rs6701037 0.748 rs2685 chr1:175127771 A/G cg14847009 chr1:175162515 KIAA0040 0.27 5.89 0.31 9.5e-9 Alcohol dependence; CRC cis rs7591163 1.000 rs2056566 chr2:228713241 G/A cg00063174 chr2:228736253 WDR69 -0.51 -6.86 -0.35 3.49e-11 Blood pressure; CRC cis rs67478160 0.634 rs941475 chr14:104240618 A/C cg01849466 chr14:104193079 ZFYVE21 -0.56 -10.42 -0.5 3.62e-22 Schizophrenia; CRC cis rs1506636 1.000 rs666266 chr7:123417759 A/G cg03229431 chr7:123269106 ASB15 0.73 11.68 0.54 1.34e-26 Plateletcrit;Platelet count; CRC cis rs9359856 0.510 rs17294495 chr6:90445753 T/G cg13799429 chr6:90582589 CASP8AP2 -0.77 -10.0 -0.48 1.01e-20 Bipolar disorder; CRC cis rs7089973 0.872 rs7918388 chr10:116614563 T/C cg23260525 chr10:116636907 FAM160B1 0.31 6.73 0.35 7.51e-11 Bipolar disorder or attention deficit hyperactivity disorder; CRC cis rs66573146 0.656 rs66517061 chr4:6935163 C/G cg00086871 chr4:6988644 TBC1D14 0.89 7.15 0.37 5.48e-12 Granulocyte percentage of myeloid white cells; CRC cis rs929354 0.742 rs6956046 chr7:156962874 G/A cg16102536 chr7:156981717 UBE3C 0.4 6.69 0.35 9.57e-11 Body mass index; CRC trans rs2727020 0.595 rs11040416 chr11:49566429 C/T cg15704280 chr7:45808275 SEPT13 -0.95 -17.88 -0.7 1.91e-50 Coronary artery disease; CRC cis rs11971779 0.680 rs4732369 chr7:139069173 C/A cg07862535 chr7:139043722 LUC7L2 0.58 7.4 0.38 1.16e-12 Diisocyanate-induced asthma; CRC cis rs4718428 0.705 rs12698547 chr7:66278258 T/C cg12165864 chr7:66369176 NA -0.41 -5.74 -0.3 2.14e-8 Corneal structure; CRC cis rs10878977 0.542 rs60964256 chr12:69815151 A/G cg20891283 chr12:69753455 YEATS4 -0.6 -5.92 -0.31 8.13e-9 Colorectal cancer; CRC cis rs9910055 0.530 rs2269905 chr17:42294462 A/G cg10896456 chr17:42255109 ASB16;C17orf65 0.34 5.92 0.31 8.29e-9 Total body bone mineral density; CRC cis rs5753618 0.583 rs5753612 chr22:31821479 T/C cg22777020 chr22:31556080 RNF185 0.5 5.98 0.31 5.84e-9 Colorectal cancer; CRC cis rs28386778 0.897 rs2584635 chr17:61865934 A/G cg07362569 chr17:61921086 SMARCD2 0.37 5.7 0.3 2.7e-8 Prudent dietary pattern; CRC cis rs2302190 0.882 rs2270098 chr17:56572081 C/T cg12560992 chr17:57184187 TRIM37 0.52 6.05 0.32 3.86e-9 Vitamin D levels; CRC cis rs6933660 0.745 rs6557138 chr6:151732017 C/T cg10883421 chr6:151773342 RMND1;C6orf211 0.71 12.45 0.57 2.06e-29 Menarche (age at onset); CRC cis rs6502050 0.835 rs8080423 chr17:80102279 A/G cg19223190 chr17:80058835 NA 0.4 6.36 0.33 6.88e-10 Life satisfaction; CRC trans rs1005277 0.579 rs2008449 chr10:38414204 A/T cg17830980 chr10:43048298 ZNF37B 0.56 9.44 0.46 7.12e-19 Extrinsic epigenetic age acceleration; CRC cis rs4654899 0.931 rs7520481 chr1:21140385 T/G cg02927042 chr1:21476669 EIF4G3 0.47 7.47 0.38 7.51e-13 Superior frontal gyrus grey matter volume; CRC cis rs9768139 0.935 rs116290351 chr7:158119712 T/A cg06219351 chr7:158114137 PTPRN2 0.44 6.6 0.34 1.68e-10 Calcium levels; CRC cis rs4713118 0.824 rs742046 chr6:27739254 A/G cg20933634 chr6:27740509 NA 0.65 9.22 0.45 3.61e-18 Parkinson's disease; CRC cis rs3087591 0.960 rs4795593 chr17:29613600 G/C cg24425628 chr17:29625626 OMG;NF1 -0.84 -16.22 -0.67 6.97e-44 Hip circumference; CRC cis rs875971 0.767 rs1643394 chr7:65836094 A/G cg18876405 chr7:65276391 NA 0.51 8.49 0.42 7.17e-16 Aortic root size; CRC cis rs7618501 1.000 rs7649348 chr3:49772375 G/A cg24308560 chr3:49941425 MST1R 0.45 7.01 0.36 1.32e-11 Intelligence (multi-trait analysis); CRC trans rs853679 0.882 rs9468300 chr6:28126840 C/T cg06606381 chr12:133084897 FBRSL1 -0.92 -7.56 -0.38 4e-13 Depression; CRC cis rs7811142 0.830 rs61735533 chr7:99955866 G/A cg00814883 chr7:100076585 TSC22D4 -0.7 -8.85 -0.44 5.49e-17 Platelet count; CRC cis rs12134245 0.719 rs61798831 chr1:91996588 C/T cg02896835 chr1:92012615 NA -0.65 -11.74 -0.54 8.01e-27 Breast cancer; CRC cis rs2153535 0.542 rs9378553 chr6:8472632 T/C cg07606381 chr6:8435919 SLC35B3 0.68 10.9 0.51 8.26e-24 Motion sickness; CRC trans rs1973993 1.000 rs1973993 chr1:96943994 A/G cg10631902 chr5:14652156 NA 0.47 8.45 0.42 9.75e-16 Weight; CRC cis rs887829 0.588 rs7556676 chr2:234658250 A/G cg02227331 chr2:234663937 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 0.42 6.84 0.35 3.96e-11 Metabolic traits;Bilirubin levels;Cholelithiasis-related traits in sickle cell anemia;Metabolite levels;Total bilirubin levels in HIV-1 infection;Serum metabolite levels;Blood metabolite levels; CRC cis rs910316 0.737 rs175424 chr14:75626257 T/C cg08847533 chr14:75593920 NEK9 -0.84 -14.54 -0.63 2.42e-37 Height; CRC cis rs9611565 0.546 rs739129 chr22:42118249 G/A cg06481639 chr22:41940642 POLR3H 0.52 5.91 0.31 8.37e-9 Vitiligo; CRC cis rs6952808 0.531 rs1107351 chr7:2177093 G/A cg02951883 chr7:2050386 MAD1L1 -0.59 -8.82 -0.44 7e-17 Bipolar disorder and schizophrenia; CRC cis rs7615952 0.599 rs60847438 chr3:125746005 T/C cg05084668 chr3:125655381 ALG1L -0.44 -6.16 -0.32 2.09e-9 Blood pressure (smoking interaction); CRC cis rs2882667 0.931 rs6596457 chr5:138323379 T/C cg09476006 chr5:138032270 NA 0.42 6.94 0.36 2.1e-11 Age-related hearing impairment (SNP x SNP interaction); CRC trans rs7615952 0.546 rs2979307 chr3:125309574 C/T cg00769240 chr8:12517080 NA 0.62 7.18 0.37 4.61e-12 Blood pressure (smoking interaction); CRC cis rs2046867 0.818 rs17010204 chr3:72879099 G/A cg25664220 chr3:72788482 NA -0.41 -6.39 -0.33 5.78e-10 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; CRC cis rs4713118 0.869 rs6901520 chr6:27714575 G/T cg25164649 chr6:28176230 NA 0.59 8.33 0.42 2.22e-15 Parkinson's disease; CRC cis rs10450586 0.830 rs10450590 chr11:27310339 G/A cg10370305 chr11:27303972 NA 0.35 5.7 0.3 2.68e-8 Total body bone mineral density; CRC cis rs17209837 0.607 rs2072384 chr7:87082868 A/T cg00919237 chr7:87102261 ABCB4 -0.54 -7.15 -0.37 5.78e-12 Gallbladder cancer; CRC cis rs2380220 0.938 rs6923253 chr6:95970141 C/G cg07718321 chr6:96025334 MANEA 0.51 5.93 0.31 7.65e-9 Behavioural disinhibition (generation interaction); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg07491357 chr18:9914943 VAPA 0.46 6.61 0.34 1.56e-10 Intelligence (multi-trait analysis); CRC cis rs12476592 0.571 rs10171223 chr2:63687700 A/G cg10828910 chr2:63850056 LOC388955 0.46 5.7 0.3 2.6e-8 Childhood ear infection; CRC cis rs17601876 0.545 rs17523270 chr15:51538280 A/C cg19946085 chr15:51559439 CYP19A1 0.3 5.9 0.31 9.25e-9 Estrone/androstenedione ratio in resected early stage-receptor positive breast cancer; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg26018965 chr1:183604789 ARPC5;RGL1 0.38 6.08 0.32 3.41e-9 Liver disease severity in Alagille syndrome; CRC cis rs6860806 0.507 rs2631362 chr5:131707293 A/G cg11843238 chr5:131593191 PDLIM4 -0.45 -7.56 -0.38 3.94e-13 Breast cancer; CRC cis rs17401966 0.931 rs10864448 chr1:10277497 A/T cg19773385 chr1:10388646 KIF1B -0.63 -9.36 -0.46 1.24e-18 Hepatocellular carcinoma; CRC cis rs12594515 0.600 rs12903858 chr15:45972166 A/G cg19682013 chr15:45996608 NA 0.28 5.6 0.3 4.5e-8 Waist circumference;Weight; CRC cis rs9807841 0.617 rs2229383 chr19:10794630 G/T cg17710535 chr19:10819994 QTRT1 0.45 6.61 0.34 1.54e-10 Inflammatory skin disease; CRC cis rs8177253 1.000 rs6762719 chr3:133480817 A/G cg11941060 chr3:133502564 NA -0.59 -10.42 -0.5 3.75e-22 Iron status biomarkers; CRC cis rs916888 0.779 rs430685 chr17:44859148 T/C cg17911788 chr17:44343683 NA 0.56 6.86 0.35 3.4e-11 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs9611565 0.694 rs9611591 chr22:41830212 G/A cg06634786 chr22:41940651 POLR3H 0.47 5.98 0.31 5.79e-9 Vitiligo; CRC cis rs8062405 0.755 rs4788080 chr16:28558081 C/T cg05139728 chr16:28306816 SBK1 -0.37 -5.99 -0.31 5.4e-9 Cognitive ability (multi-trait analysis);Cognitive ability; CRC cis rs2839186 0.605 rs2839170 chr21:47671305 A/G cg09417038 chr21:47716443 C21orf57 -0.39 -6.43 -0.33 4.49e-10 Testicular germ cell tumor; CRC cis rs6912958 0.631 rs9450704 chr6:88182704 G/C cg12350822 chr6:88032061 C6orf162;GJB7 -0.36 -6.71 -0.35 8.31e-11 Monocyte percentage of white cells; CRC cis rs10504229 0.953 rs72652908 chr8:58191324 G/A cg24829409 chr8:58192753 C8orf71 -0.68 -11.34 -0.53 2.27e-25 Developmental language disorder (linguistic errors); CRC cis rs3733346 0.520 rs62297086 chr4:909040 G/A cg23939001 chr4:940644 TMEM175 0.72 15.1 0.64 1.65e-39 Sjögren's syndrome; CRC cis rs748404 0.660 rs2467741 chr15:43742626 T/C cg02155558 chr15:43621948 ADAL;LCMT2 0.51 7.45 0.38 8.33e-13 Lung cancer; CRC cis rs12950390 0.853 rs55745341 chr17:45855778 G/C cg24803719 chr17:45855879 NA -0.31 -6.91 -0.36 2.53e-11 IgG glycosylation; CRC cis rs9443645 0.901 rs9352666 chr6:79572184 C/G cg09184832 chr6:79620586 NA -0.5 -9.44 -0.46 7.08e-19 Intelligence (multi-trait analysis); CRC trans rs2243480 1.000 rs55895244 chr7:65387678 C/G cg10756647 chr7:56101905 PSPH 0.73 8.07 0.41 1.36e-14 Diabetic kidney disease; CRC cis rs7605827 0.930 rs3796002 chr2:15567649 T/C cg19274914 chr2:15703543 NA 0.39 5.95 0.31 6.78e-9 Educational attainment (years of education); CRC cis rs2153535 0.580 rs7763190 chr6:8484197 G/A cg07606381 chr6:8435919 SLC35B3 0.68 10.89 0.51 8.84e-24 Motion sickness; CRC cis rs7647973 0.516 rs4308307 chr3:49193216 C/T cg07690219 chr3:49449608 TCTA;RHOA -0.45 -5.81 -0.31 1.48e-8 Menarche (age at onset); CRC cis rs68170813 0.559 rs11773514 chr7:106958469 T/C cg02696742 chr7:106810147 HBP1 -0.6 -6.6 -0.34 1.64e-10 Coronary artery disease; CRC cis rs4474465 0.688 rs7108439 chr11:78277708 A/T cg27205649 chr11:78285834 NARS2 0.53 6.88 0.35 2.99e-11 Alzheimer's disease (survival time); CRC cis rs425277 0.538 rs169037 chr1:2095582 G/T cg12639453 chr1:2035780 PRKCZ 0.31 5.7 0.3 2.67e-8 Height; CRC trans rs57221529 0.709 rs72706612 chr5:561198 C/T cg11887960 chr12:57824829 NA 0.58 6.42 0.33 4.87e-10 Lung disease severity in cystic fibrosis; CRC cis rs7937682 0.889 rs7948236 chr11:111499933 C/A cg09085632 chr11:111637200 PPP2R1B -1.03 -20.7 -0.75 1.55e-61 Primary sclerosing cholangitis; CRC cis rs2411233 1.000 rs13379846 chr15:39272413 T/A cg23129342 chr15:39283510 NA 0.31 5.71 0.3 2.48e-8 Platelet count; CRC cis rs17155006 0.655 rs380046 chr7:107728315 A/G cg05962710 chr7:107745446 LAMB4 -0.35 -5.85 -0.31 1.16e-8 Pneumococcal bacteremia; CRC cis rs801193 0.967 rs2707853 chr7:66214010 G/A cg00343986 chr7:65444356 GUSB 0.49 7.26 0.37 2.87e-12 Aortic root size; CRC cis rs765787 0.530 rs4775832 chr15:45534828 A/G cg24006582 chr15:45444508 DUOX1 -0.57 -8.79 -0.44 8.5e-17 Uric acid levels; CRC cis rs7605827 0.930 rs12692265 chr2:15544998 T/C cg19274914 chr2:15703543 NA 0.4 5.9 0.31 9.12e-9 Educational attainment (years of education); CRC cis rs7584330 0.638 rs13429533 chr2:238448712 A/G cg16989719 chr2:238392110 NA -0.4 -8.2 -0.41 5.58e-15 Prostate cancer; CRC cis rs7223966 1.000 rs16947014 chr17:61719032 C/T cg05941027 chr17:61774174 LIMD2 0.35 6.38 0.33 5.92e-10 Hip circumference adjusted for BMI;Body mass index; CRC cis rs4363385 0.747 rs2339494 chr1:152975143 G/C cg25856811 chr1:152973957 SPRR3 -0.26 -7.23 -0.37 3.42e-12 Inflammatory skin disease; CRC cis rs875971 0.660 rs801211 chr7:66015689 T/G cg00343986 chr7:65444356 GUSB -0.49 -7.42 -0.38 1e-12 Aortic root size; CRC cis rs867529 1.000 rs11681299 chr2:88901732 C/T cg26627705 chr2:89060884 NA -0.51 -6.46 -0.34 3.73e-10 Height; CRC cis rs6582630 0.502 rs11181475 chr12:38348922 G/A cg26384229 chr12:38710491 ALG10B 0.68 9.77 0.47 5.8e-20 Drug-induced liver injury (flucloxacillin); CRC cis rs2072510 0.593 rs2247304 chr12:96424665 T/C cg22491680 chr12:96389547 HAL -0.48 -6.04 -0.32 4.14e-9 Metabolite levels (small molecules and protein measures); CRC cis rs9486719 1.000 rs72931061 chr6:96880285 G/A cg06623918 chr6:96969491 KIAA0776 -0.81 -9.51 -0.46 4.17e-19 Migraine;Coronary artery disease; CRC trans rs1814175 0.817 rs1390676 chr11:50056778 C/T cg15704280 chr7:45808275 SEPT13 -0.97 -19.11 -0.73 2.72e-55 Height; CRC cis rs911555 0.755 rs35233301 chr14:103885291 A/G cg12935359 chr14:103987150 CKB 0.59 9.26 0.45 2.73e-18 Intelligence (multi-trait analysis); CRC cis rs9322193 0.962 rs952165 chr6:150120036 T/C cg00933542 chr6:150070202 PCMT1 0.28 5.63 0.3 3.86e-8 Lung cancer; CRC cis rs13256369 0.755 rs12550057 chr8:8562268 G/A cg17143192 chr8:8559678 CLDN23 0.52 6.69 0.35 9.44e-11 Obesity-related traits; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg11949945 chr9:123342512 CDK5RAP2 0.43 6.16 0.32 2.1e-9 Intelligence (multi-trait analysis); CRC cis rs7493 0.950 rs17166868 chr7:95033416 C/T cg17330251 chr7:94953956 PON1 -0.59 -7.65 -0.39 2.27e-13 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs2739330 0.828 rs5760108 chr22:24252668 G/T cg04234412 chr22:24373322 LOC391322 -0.73 -11.68 -0.54 1.35e-26 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs2072499 1.000 rs2540173 chr1:156188214 A/G cg24450063 chr1:156163899 SLC25A44 1.15 27.07 0.83 1.05e-85 Testicular germ cell tumor; CRC cis rs57221529 0.766 rs72703026 chr5:572383 G/A cg14541582 chr5:601475 NA -0.33 -6.53 -0.34 2.53e-10 Lung disease severity in cystic fibrosis; CRC cis rs3736485 0.966 rs10467924 chr15:51787579 A/G cg08986416 chr15:51914746 DMXL2 -0.45 -6.53 -0.34 2.48e-10 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs225245 0.791 rs3890901 chr17:34011322 A/C cg05299278 chr17:33885742 SLFN14 0.5 8.19 0.41 6.01e-15 Reticulocyte count;Reticulocyte fraction of red cells;High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells; CRC cis rs4819052 0.679 rs4819053 chr21:46711357 C/T cg11663144 chr21:46675770 NA 0.63 10.59 0.5 9.85e-23 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs10779751 0.686 rs2791656 chr1:11128329 A/G cg08854313 chr1:11322531 MTOR 0.65 8.71 0.43 1.48e-16 Body mass index; CRC cis rs1862618 0.853 rs832578 chr5:56164223 C/T cg03609598 chr5:56110824 MAP3K1 -0.85 -10.23 -0.49 1.66e-21 Initial pursuit acceleration; CRC cis rs2179367 0.959 rs652807 chr6:149737495 A/G cg11245181 chr6:149772854 ZC3H12D 0.38 5.89 0.31 9.47e-9 Dupuytren's disease; CRC cis rs34375054 0.624 rs7132026 chr12:125678096 A/G cg02766259 chr12:125626809 AACS 0.44 7.1 0.36 7.94e-12 Post bronchodilator FEV1/FVC ratio; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg03900353 chr1:212732456 NA 0.49 6.94 0.36 2.13e-11 Response to antipsychotic treatment; CRC trans rs4942242 1.000 rs7331003 chr13:44230253 C/T cg19169023 chr15:41853346 TYRO3 -0.55 -8.42 -0.42 1.21e-15 Response to tocilizumab in rheumatoid arthritis; CRC trans rs459571 1.000 rs456207 chr9:136911140 G/A cg09836344 chr4:1243392 C4orf42;CTBP1 -0.77 -11.1 -0.52 1.53e-24 Platelet distribution width; CRC cis rs748404 0.631 rs8042688 chr15:43638525 G/A cg15269541 chr15:43626905 ADAL -0.37 -5.63 -0.3 3.93e-8 Lung cancer; CRC cis rs5753618 0.583 rs738657 chr22:31841749 T/A cg02404636 chr22:31891804 SFI1 0.44 5.86 0.31 1.13e-8 Colorectal cancer; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg06537201 chr12:58330115 NA 0.45 6.89 0.36 2.79e-11 Liver disease severity in Alagille syndrome; CRC cis rs1832871 0.672 rs9456295 chr6:158772078 G/A cg07165851 chr6:158734300 TULP4 0.62 7.81 0.4 7.61e-14 Height; CRC cis rs9467711 0.606 rs9366656 chr6:26434630 T/C cg12315302 chr6:26189340 HIST1H4D 0.82 6.33 0.33 8.12e-10 Autism spectrum disorder or schizophrenia; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg17391141 chr20:49575376 MOCS3;DPM1 0.48 6.85 0.35 3.75e-11 Response to antipsychotic treatment; CRC cis rs11098499 0.955 rs35197422 chr4:120169314 T/G cg24375607 chr4:120327624 NA 0.44 6.82 0.35 4.49e-11 Corneal astigmatism; CRC cis rs7615952 0.641 rs12491577 chr3:125731131 C/T cg02772935 chr3:125709198 NA -0.51 -6.07 -0.32 3.5e-9 Blood pressure (smoking interaction); CRC cis rs7945705 0.747 rs1123936 chr11:9003306 A/G cg12365402 chr11:9010492 NRIP3 -0.58 -10.71 -0.51 3.66e-23 Hemoglobin concentration; CRC cis rs992157 0.661 rs17653757 chr2:219109364 G/C cg00012203 chr2:219082015 ARPC2 0.63 10.43 0.5 3.39e-22 Colorectal cancer; CRC cis rs2200578 1.000 rs116648076 chr2:99882347 T/A cg26064155 chr2:99771622 LIPT1;TSGA10 0.54 6.04 0.32 4.05e-9 IgG glycosylation; CRC cis rs9549367 0.713 rs510160 chr13:113822481 A/G cg00898013 chr13:113819073 PROZ 0.51 7.65 0.39 2.21e-13 Platelet distribution width; CRC trans rs2303319 0.504 rs62189053 chr2:162624324 G/A cg22922770 chr7:98923339 ARPC1A -0.67 -5.99 -0.31 5.55e-9 Cognitive function; CRC trans rs2228479 1.000 rs2228479 chr16:89985940 G/A cg24644049 chr4:85504048 CDS1 0.8 6.98 0.36 1.66e-11 Skin colour saturation; CRC cis rs4713118 0.539 rs510987 chr6:27847517 G/A cg02683197 chr6:28174875 NA 0.69 9.49 0.46 4.74e-19 Parkinson's disease; CRC cis rs1018836 0.923 rs34126139 chr8:91572045 T/G cg16814680 chr8:91681699 NA -0.74 -11.82 -0.55 4.13e-27 Ejection fraction in Tripanosoma cruzi seropositivity; CRC cis rs9560113 0.922 rs4773377 chr13:112174152 G/C cg10483660 chr13:112241077 NA 0.35 5.65 0.3 3.57e-8 Menarche (age at onset); CRC cis rs1552244 0.572 rs67439440 chr3:10169503 C/T cg18598329 chr3:10140678 FANCD2;C3orf24 -0.9 -10.73 -0.51 3.19e-23 Alzheimer's disease; CRC cis rs2421770 0.530 rs4756218 chr11:35370113 G/A cg13971030 chr11:35366721 SLC1A2 -0.38 -6.59 -0.34 1.75e-10 Staphylococcus aureus nasal carriage (persistent); CRC cis rs57590327 0.503 rs7631052 chr3:81866235 C/A cg07356753 chr3:81810745 GBE1 -0.6 -8.27 -0.42 3.28e-15 Extraversion; CRC cis rs478304 0.627 rs1073602 chr11:65455386 G/C cg05805236 chr11:65401703 PCNXL3 -0.42 -6.69 -0.35 9.75e-11 Acne (severe); CRC cis rs7727544 0.904 rs58835386 chr5:131600559 A/G cg18758796 chr5:131593413 PDLIM4 0.32 5.94 0.31 7.16e-9 Blood metabolite levels; CRC trans rs629535 0.814 rs72654071 chr8:70079484 A/G cg21567404 chr3:27674614 NA -0.94 -15.18 -0.64 8.33e-40 Dupuytren's disease; CRC cis rs853679 0.517 rs9357061 chr6:28051772 A/G cg25164649 chr6:28176230 NA 0.73 9.18 0.45 4.85e-18 Depression; CRC cis rs12410462 0.579 rs78343168 chr1:227621090 G/A cg04117972 chr1:227635322 NA 0.87 8.88 0.44 4.34e-17 Major depressive disorder; CRC cis rs968567 0.559 rs174548 chr11:61571348 C/G cg06781209 chr11:61594997 FADS2 -0.41 -6.02 -0.32 4.6e-9 Blood metabolite levels;Rheumatoid arthritis;Vitiligo;Glycerophospholipid levels; CRC cis rs10504229 0.683 rs11781690 chr8:58132931 C/G cg02725872 chr8:58115012 NA -0.64 -11.55 -0.54 3.85e-26 Developmental language disorder (linguistic errors); CRC cis rs8060686 0.920 rs16942887 chr16:67928042 G/A cg07125278 chr16:67683757 RLTPR -0.63 -7.25 -0.37 3.09e-12 HDL cholesterol;Metabolic syndrome; CRC cis rs881375 0.933 rs4837804 chr9:123705304 C/G cg09419670 chr9:123605666 PSMD5;LOC253039 0.56 8.28 0.42 3.08e-15 Rheumatoid arthritis; CRC cis rs8072100 0.748 rs9908016 chr17:45551361 G/A cg25173405 chr17:45401733 C17orf57 -0.44 -6.77 -0.35 5.79e-11 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs13217239 0.646 rs12523820 chr6:27001502 A/G cg05192639 chr6:26864778 GUSBL1 0.31 6.05 0.32 4.01e-9 Schizophrenia; CRC cis rs6831352 0.918 rs2602891 chr4:100043284 C/T cg13256891 chr4:100009986 ADH5 0.67 9.15 0.45 6.18e-18 Alcohol dependence; CRC cis rs478304 0.651 rs948494 chr11:65552118 G/A cg27068330 chr11:65405492 SIPA1 -0.63 -9.33 -0.46 1.66e-18 Acne (severe); CRC cis rs9814567 0.806 rs9841371 chr3:134320765 A/G cg06541857 chr3:134203789 ANAPC13;CEP63 -0.37 -5.73 -0.3 2.3e-8 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs8060686 0.858 rs1476306 chr16:67973171 C/T cg26727032 chr16:67993705 SLC12A4 -0.71 -10.74 -0.51 2.93e-23 HDL cholesterol;Metabolic syndrome; CRC cis rs11191270 0.554 rs11191275 chr10:104142800 C/T cg15320455 chr10:103880129 LDB1 0.73 6.76 0.35 6.46e-11 Intelligence (multi-trait analysis); CRC cis rs243505 1.000 rs243502 chr7:148437205 C/T cg09806900 chr7:148480153 CUL1 -0.47 -6.61 -0.34 1.6e-10 Inflammatory bowel disease;Crohn's disease; CRC trans rs2303319 0.504 rs1006428 chr2:162592559 A/C cg11326919 chr17:43324904 LOC100133991 -0.64 -5.97 -0.31 5.99e-9 Cognitive function; CRC cis rs9443645 0.527 rs10943608 chr6:79674929 T/C cg09184832 chr6:79620586 NA -0.46 -7.96 -0.4 2.81e-14 Intelligence (multi-trait analysis); CRC cis rs1023500 0.552 rs133368 chr22:42463689 T/C cg11915388 chr22:42470451 FAM109B -0.42 -6.36 -0.33 6.8e-10 Schizophrenia; CRC cis rs1814175 0.529 rs10839396 chr11:49852406 G/T cg27395922 chr11:50257633 LOC441601 0.41 6.9 0.36 2.65e-11 Height; CRC cis rs2952156 0.920 rs2934951 chr17:37833328 A/G cg00129232 chr17:37814104 STARD3 -0.67 -11.66 -0.54 1.52e-26 Asthma; CRC cis rs12431939 0.947 rs68164178 chr14:51679003 A/C cg23942311 chr14:51606299 NA -0.53 -6.31 -0.33 8.91e-10 Cancer; CRC cis rs12042938 0.622 rs58403453 chr1:231813438 C/T cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX 0.42 5.65 0.3 3.49e-8 Neuranatomic and neurocognitive phenotypes; CRC cis rs17213078 0.505 rs3795909 chr2:106754734 A/G cg15412446 chr2:106886593 NA 0.36 5.7 0.3 2.65e-8 Facial morphology (factor 23); CRC cis rs4561483 0.583 rs1029285 chr16:11987118 G/A cg08843971 chr16:11963173 GSPT1 0.51 7.6 0.39 3.07e-13 Testicular germ cell tumor; CRC cis rs6570726 0.791 rs405206 chr6:145836873 C/A cg13319975 chr6:146136371 FBXO30 -0.44 -6.66 -0.34 1.13e-10 Lobe attachment (rater-scored or self-reported); CRC cis rs2739330 0.734 rs2000467 chr22:24241533 C/T cg23131131 chr22:24373011 LOC391322 0.66 9.76 0.47 6.05e-20 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs7503807 0.967 rs12947696 chr17:78596793 C/T cg09596252 chr17:78655493 RPTOR 0.41 6.45 0.34 3.9e-10 Obesity; CRC cis rs3771570 1.000 rs62186400 chr2:242226700 A/G cg21155796 chr2:242212141 HDLBP 0.64 7.0 0.36 1.48e-11 Prostate cancer; CRC trans rs1814175 0.645 rs10839456 chr11:49964093 C/T cg11707556 chr5:10655725 ANKRD33B -0.52 -9.83 -0.48 3.53e-20 Height; CRC cis rs2243480 1.000 rs35735127 chr7:65300423 G/T cg18252515 chr7:66147081 NA -1.17 -13.55 -0.6 1.59e-33 Diabetic kidney disease; CRC cis rs2652834 1.000 rs8032104 chr15:63400584 A/G cg05507819 chr15:63340323 TPM1 0.46 5.75 0.3 2.05e-8 HDL cholesterol; CRC cis rs9443645 0.901 rs9443638 chr6:79720867 T/A cg11833968 chr6:79620685 NA -0.35 -6.04 -0.32 4.19e-9 Intelligence (multi-trait analysis); CRC cis rs3749237 1.000 rs2291542 chr3:49751585 C/T cg03060546 chr3:49711283 APEH 0.43 6.52 0.34 2.68e-10 Resting heart rate; CRC cis rs9325144 0.560 rs10785562 chr12:38637419 A/C cg13010199 chr12:38710504 ALG10B -0.43 -6.12 -0.32 2.59e-9 Morning vs. evening chronotype; CRC cis rs7827545 1.000 rs6578235 chr8:135568022 C/T cg17885191 chr8:135476712 NA 0.51 7.16 0.37 5.21e-12 Hypertension (SNP x SNP interaction); CRC cis rs651907 0.535 rs11712309 chr3:101519097 T/C cg11279151 chr3:101281821 RG9MTD1 -0.53 -7.09 -0.36 8.3e-12 Colorectal cancer; CRC cis rs12477438 0.798 rs6759354 chr2:99632195 A/G cg14399236 chr2:99771627 LIPT1;TSGA10 -0.74 -10.4 -0.5 4.36e-22 Chronic sinus infection; CRC cis rs3741404 0.620 rs2236647 chr11:63964605 A/G cg15107132 chr11:63991130 FERMT3 0.43 7.38 0.38 1.27e-12 Platelet count; CRC cis rs9467773 0.620 rs2494701 chr6:26634432 C/T cg09904177 chr6:26538194 HMGN4 0.72 11.39 0.53 1.42e-25 Intelligence (multi-trait analysis); CRC cis rs10504229 0.817 rs35207430 chr8:58167614 G/A cg21724239 chr8:58056113 NA 0.4 5.94 0.31 7.28e-9 Developmental language disorder (linguistic errors); CRC cis rs6502050 0.765 rs55905076 chr17:80105441 G/A cg11859384 chr17:80120422 CCDC57 -0.36 -5.72 -0.3 2.36e-8 Life satisfaction; CRC cis rs17767392 0.681 rs4899390 chr14:71680348 C/G cg13720639 chr14:72061746 SIPA1L1 -0.51 -6.19 -0.32 1.75e-9 Mitral valve prolapse; CRC cis rs6951245 0.554 rs10246354 chr7:1132456 C/T cg21664854 chr7:1097933 C7orf50;GPR146 0.6 7.49 0.38 6.49e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs11233250 0.502 rs59617763 chr11:82402396 A/G cg17391194 chr11:82401662 NA 0.44 6.77 0.35 5.77e-11 Glioblastoma;Glioma; CRC cis rs4862750 0.914 rs1346126 chr4:187876404 T/C cg11301795 chr4:187892539 NA -0.84 -18.71 -0.72 1.08e-53 Lobe attachment (rater-scored or self-reported); CRC cis rs1215050 0.791 rs1669745 chr4:98842047 G/A cg05340658 chr4:99064831 C4orf37 -0.49 -7.33 -0.37 1.8e-12 Waist-to-hip ratio adjusted for body mass index; CRC cis rs1801251 0.963 rs6739638 chr2:233576015 G/A cg25237894 chr2:233734115 C2orf82 0.53 8.53 0.43 5.46e-16 Coronary artery disease; CRC cis rs17155006 0.561 rs22783 chr7:107743243 G/T cg05962710 chr7:107745446 LAMB4 -0.43 -7.63 -0.39 2.54e-13 Pneumococcal bacteremia; CRC cis rs801193 0.773 rs801207 chr7:66020590 T/C cg00343986 chr7:65444356 GUSB -0.47 -7.04 -0.36 1.15e-11 Aortic root size; CRC cis rs56399783 0.901 rs11971014 chr7:2778444 C/T cg19731401 chr7:2775893 GNA12 0.57 6.39 0.33 5.6e-10 Childhood ear infection; CRC cis rs13064411 0.696 rs6799610 chr3:113248748 A/C cg10517650 chr3:113235015 CCDC52 0.42 7.32 0.37 1.9e-12 Response to simvastatin treatment (PCSK9 protein level change); CRC cis rs8036030 0.604 rs11852686 chr15:74715205 A/G cg14664628 chr15:75095509 CSK -0.47 -6.59 -0.34 1.78e-10 Airflow obstruction; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg03869194 chr19:59031081 ZBTB45 0.46 6.62 0.34 1.47e-10 Intelligence (multi-trait analysis); CRC cis rs4478858 0.735 rs6679393 chr1:31770944 T/C cg00250761 chr1:31883323 NA -0.43 -8.43 -0.42 1.12e-15 Alcohol dependence; CRC cis rs10512697 0.655 rs35912980 chr5:3458039 G/C cg19473799 chr5:3511975 NA -0.83 -6.34 -0.33 7.66e-10 Immune response to smallpox vaccine (IL-6); CRC cis rs9916302 0.752 rs12150047 chr17:37601755 A/G cg00129232 chr17:37814104 STARD3 -0.58 -7.18 -0.37 4.56e-12 Glomerular filtration rate (creatinine); CRC cis rs875971 0.862 rs2909688 chr7:65841612 C/A cg12463550 chr7:65579703 CRCP 0.48 6.49 0.34 3.07e-10 Aortic root size; CRC cis rs3862030 0.720 rs11595149 chr10:104235978 C/T cg11453585 chr10:104263688 ACTR1A;SUFU -0.8 -14.09 -0.61 1.27e-35 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for body mass index; CRC cis rs2795502 0.882 rs3123754 chr10:43339011 G/A cg27426351 chr10:43362370 NA -0.6 -7.12 -0.37 6.96e-12 Blood protein levels; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg02683314 chr19:4182606 SIRT6;ANKRD24 0.38 6.38 0.33 5.99e-10 Liver disease severity in Alagille syndrome; CRC cis rs9462027 0.583 rs11755420 chr6:34760956 C/G cg07306190 chr6:34760872 UHRF1BP1 -0.35 -6.24 -0.33 1.31e-9 Systemic lupus erythematosus; CRC cis rs6088590 1.000 rs6088615 chr20:33400474 C/T cg24642439 chr20:33292090 TP53INP2 -0.6 -10.86 -0.51 1.08e-23 Coronary artery disease; CRC cis rs9462846 0.919 rs9471966 chr6:42891022 G/A cg02353165 chr6:42928485 GNMT 0.47 6.42 0.33 4.81e-10 Blood protein levels; CRC cis rs1559088 0.545 rs7257431 chr19:33566924 A/G cg17764715 chr19:33622953 WDR88 0.47 6.84 0.35 3.89e-11 Bone ultrasound measurement (broadband ultrasound attenuation); CRC cis rs1862618 0.853 rs43184 chr5:56141777 G/C cg18230493 chr5:56204884 C5orf35 -0.72 -9.19 -0.45 4.45e-18 Initial pursuit acceleration; CRC cis rs9914988 0.887 rs9895625 chr17:27108516 A/G cg12682573 chr17:27188876 MIR451;MIR144 0.58 7.99 0.4 2.37e-14 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs2735413 0.881 rs12919818 chr16:78082862 C/T cg04733911 chr16:78082701 NA -0.46 -7.58 -0.39 3.46e-13 Systolic blood pressure (alcohol consumption interaction); CRC cis rs1691799 0.899 rs1168329 chr12:66731864 C/A cg16791601 chr12:66731901 HELB -0.73 -12.87 -0.58 5.73e-31 White blood cell count (basophil); CRC cis rs1005277 0.579 rs2474569 chr10:38383491 C/G cg00409905 chr10:38381863 ZNF37A -0.68 -11.31 -0.53 2.89e-25 Extrinsic epigenetic age acceleration; CRC cis rs9322193 0.923 rs9766886 chr6:149958184 T/C cg07701084 chr6:150067640 NUP43 0.55 8.04 0.41 1.58e-14 Lung cancer; CRC cis rs9733 0.566 rs11204675 chr1:150570985 A/C cg10589385 chr1:150898437 SETDB1 -0.26 -5.83 -0.31 1.36e-8 Tonsillectomy; CRC cis rs1580019 0.713 rs2167274 chr7:32524844 A/G cg06627557 chr7:32535165 LSM5;AVL9 0.98 18.49 0.71 7.34e-53 Cognitive ability; CRC cis rs10504229 0.775 rs17805026 chr8:58160637 A/C cg02725872 chr8:58115012 NA -0.59 -9.18 -0.45 4.97e-18 Developmental language disorder (linguistic errors); CRC cis rs9611565 0.659 rs12483998 chr22:41935362 A/G cg03806693 chr22:41940476 POLR3H -1.14 -14.68 -0.63 7.23e-38 Vitiligo; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg07649646 chr14:73525051 RBM25 0.42 6.06 0.32 3.7e-9 Intelligence (multi-trait analysis); CRC cis rs12200560 0.505 rs211179 chr6:97074103 A/G cg06623918 chr6:96969491 KIAA0776 0.52 7.64 0.39 2.37e-13 Coronary heart disease; CRC cis rs763121 0.853 rs5750677 chr22:39147715 C/T cg06544989 chr22:39130855 UNC84B 0.46 6.82 0.35 4.44e-11 Menopause (age at onset); CRC cis rs11190604 1.000 rs17113137 chr10:102241998 G/C cg07080220 chr10:102295463 HIF1AN 0.48 5.76 0.3 1.93e-8 Palmitoleic acid (16:1n-7) levels; CRC cis rs868943 0.714 rs1999930 chr6:116387134 C/T cg15226275 chr6:116381976 FRK 0.31 7.31 0.37 2.09e-12 Total cholesterol levels; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg13886636 chr9:130679606 ST6GALNAC4 0.43 6.17 0.32 2.02e-9 Intelligence (multi-trait analysis); CRC cis rs2404602 0.716 rs284895 chr15:76751225 C/G cg23625390 chr15:77176239 SCAPER -0.5 -7.31 -0.37 2.07e-12 Blood metabolite levels; CRC cis rs4973397 0.921 rs12622248 chr2:232289127 G/A cg13347044 chr2:232276743 NA 0.5 6.9 0.36 2.74e-11 Anti-saccade response; CRC cis rs2692947 0.637 rs1168967 chr2:96826016 A/G cg23100626 chr2:96804247 ASTL 0.3 8.18 0.41 6.43e-15 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg03425468 chr1:155164676 MIR92B 0.38 6.08 0.32 3.37e-9 Obesity-related traits; CRC cis rs870825 0.616 rs6552802 chr4:185620751 C/G cg04058563 chr4:185651563 MLF1IP 0.72 9.38 0.46 1.12e-18 Blood protein levels; CRC cis rs6502050 0.799 rs7502524 chr17:80107261 C/T cg11859384 chr17:80120422 CCDC57 -0.37 -5.85 -0.31 1.16e-8 Life satisfaction; CRC trans rs10242455 0.557 rs77997620 chr7:99070415 G/T cg09045935 chr12:6379348 NA 1.14 8.88 0.44 4.43e-17 Blood metabolite levels; CRC cis rs7223966 1.000 rs7222060 chr17:61868279 C/T cg05941027 chr17:61774174 LIMD2 0.35 6.31 0.33 8.87e-10 Hip circumference adjusted for BMI;Body mass index; CRC cis rs2617583 0.967 rs2652510 chr5:1447860 C/T cg07151155 chr5:1473589 LPCAT1 -0.42 -6.5 -0.34 2.9e-10 Breast cancer; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg11521799 chr20:2451663 SNRPB 0.44 6.4 0.33 5.51e-10 Intelligence (multi-trait analysis); CRC cis rs9322193 0.923 rs62441284 chr6:150072678 C/A cg07701084 chr6:150067640 NUP43 0.59 8.75 0.43 1.14e-16 Lung cancer; CRC cis rs6484504 0.576 rs208067 chr11:31153578 C/T cg14844989 chr11:31128820 NA -0.34 -5.9 -0.31 8.79e-9 Red blood cell count; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg23141096 chr10:98347050 TM9SF3 0.42 5.99 0.31 5.48e-9 Response to antipsychotic treatment; CRC cis rs9911578 1.000 rs3744109 chr17:56594197 C/T cg12560992 chr17:57184187 TRIM37 -0.91 -17.1 -0.69 2.31e-47 Intelligence (multi-trait analysis); CRC trans rs35110281 0.591 rs162369 chr21:44931965 G/A cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.47 7.66 0.39 2.16e-13 Mean corpuscular volume; CRC trans rs4512344 0.509 rs2409784 chr8:11396856 G/T cg16141378 chr3:129829833 LOC729375 0.47 6.94 0.36 2.06e-11 Bone ultrasound measurement (broadband ultrasound attenuation); CRC cis rs7937682 1.000 rs505372 chr11:111507189 A/C cg09085632 chr11:111637200 PPP2R1B -1.01 -19.44 -0.73 1.33e-56 Primary sclerosing cholangitis; CRC cis rs754466 0.606 rs7084705 chr10:79596675 A/G cg26805224 chr10:79626177 DLG5 -0.41 -5.9 -0.31 8.91e-9 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs55665837 1.000 rs3923294 chr11:14441402 T/G cg19336497 chr11:14380999 RRAS2 -0.39 -6.61 -0.34 1.58e-10 Vitamin D levels; CRC trans rs916888 0.647 rs199449 chr17:44808902 G/A cg22968622 chr17:43663579 NA 0.89 12.22 0.56 1.43e-28 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs12134245 0.874 rs34842487 chr1:92021611 C/T cg25838465 chr1:92012736 NA -0.57 -9.65 -0.47 1.46e-19 Breast cancer; CRC trans rs587242 1.000 rs509770 chr1:96891615 G/A cg10631902 chr5:14652156 NA 0.45 6.9 0.36 2.7e-11 Body mass index (joint analysis main effects and physical activity interaction);Body mass index in physically inactive individuals;Body mass index; CRC cis rs6088590 0.813 rs1884668 chr20:33285514 A/G cg24642439 chr20:33292090 TP53INP2 0.46 8.04 0.41 1.68e-14 Coronary artery disease; CRC cis rs17401966 0.558 rs6541090 chr1:10402842 A/G cg19773385 chr1:10388646 KIF1B -0.46 -7.17 -0.37 4.95e-12 Hepatocellular carcinoma; CRC trans rs1728785 1.000 rs1170433 chr16:68606081 A/G cg04657470 chr2:198365150 HSPE1;HSPD1 0.59 7.14 0.37 6.11e-12 Ulcerative colitis; CRC cis rs1448094 0.512 rs6539926 chr12:86244460 G/A cg02569458 chr12:86230093 RASSF9 0.42 7.24 0.37 3.17e-12 Major depressive disorder; CRC cis rs754466 0.606 rs3740250 chr10:79580101 C/T cg17075019 chr10:79541650 NA -0.98 -19.1 -0.73 2.86e-55 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs62244186 0.659 rs4682745 chr3:44508967 T/C cg18165381 chr3:44552316 NA -0.38 -5.69 -0.3 2.8e-8 Depressive symptoms; CRC cis rs7998202 0.667 rs282579 chr13:113358436 G/C cg01692110 chr13:113365389 ATP11A -0.45 -5.61 -0.3 4.24e-8 Glycated hemoglobin levels; CRC cis rs2070488 0.804 rs13085153 chr3:38461279 A/G cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.8 13.84 0.61 1.22e-34 Electrocardiographic conduction measures; CRC cis rs11677370 0.561 rs10191326 chr2:3827524 G/C cg17052675 chr2:3827356 NA -0.66 -11.12 -0.52 1.36e-24 Type 2 diabetes; CRC cis rs1030877 0.889 rs2576746 chr2:105909559 G/A cg02079111 chr2:105885981 TGFBRAP1 0.68 12.63 0.57 4.45e-30 Obesity-related traits; CRC cis rs7209700 0.692 rs11652097 chr17:45316717 C/T cg08085267 chr17:45401833 C17orf57 0.48 6.9 0.36 2.69e-11 IgG glycosylation; CRC cis rs6500602 0.647 rs4786514 chr16:4576798 A/C cg08645402 chr16:4508243 NA 0.59 9.52 0.46 3.76e-19 Schizophrenia; CRC cis rs9303401 0.659 rs11495824 chr17:56918882 C/A cg10487724 chr17:56770010 TEX14;RAD51C 0.76 9.53 0.47 3.57e-19 Cognitive test performance; CRC cis rs1003719 0.788 rs4817843 chr21:38447040 C/A cg10648535 chr21:38446584 PIGP;TTC3 0.53 7.58 0.39 3.56e-13 Eye color traits; CRC trans rs10982213 0.830 rs2274163 chr9:117188714 C/T cg05518842 chr16:1823291 MRPS34;EME2 0.34 5.97 0.31 6.15e-9 Interleukin-6 levels; CRC cis rs933688 0.938 rs10063683 chr5:90714595 G/A cg26981201 chr5:90679533 LOC100129716;ARRDC3 1.02 15.59 0.65 1.97e-41 Smoking behavior; CRC cis rs9322193 0.923 rs62441279 chr6:150042330 G/A cg05861140 chr6:150128134 PCMT1 -0.36 -5.88 -0.31 1e-8 Lung cancer; CRC cis rs2832191 0.729 rs2832201 chr21:30499841 A/G cg24692254 chr21:30365293 RNF160 -0.78 -13.5 -0.6 2.35e-33 Dental caries; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg26883264 chr1:151483574 CGN 0.43 6.25 0.33 1.24e-9 Response to antipsychotic treatment; CRC cis rs1322512 1.000 rs1405694 chr6:152946561 C/T cg03415253 chr6:152958462 SYNE1 -0.43 -6.83 -0.35 4.14e-11 Tonometry; CRC cis rs10789491 1.000 rs1440487 chr1:47167075 C/T cg15501359 chr1:47185051 KIAA0494 -0.68 -8.39 -0.42 1.44e-15 Response to hepatitis C treatment; CRC cis rs9858542 0.953 rs3811699 chr3:49396360 T/C cg07274523 chr3:49395745 GPX1 0.45 6.05 0.32 4.03e-9 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs9443645 0.527 rs9361477 chr6:79710806 C/T cg09184832 chr6:79620586 NA -0.46 -7.86 -0.4 5.67e-14 Intelligence (multi-trait analysis); CRC trans rs875971 0.660 rs2191268 chr7:66110224 C/T cg19927065 chr19:1122678 SBNO2 0.35 5.98 0.31 5.79e-9 Aortic root size; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg21584983 chr19:11640070 ECSIT 0.5 6.44 0.33 4.15e-10 Thyroid stimulating hormone; CRC cis rs7224685 0.501 rs781845 chr17:3958341 A/G cg11204139 chr17:3907470 NA -0.75 -14.15 -0.62 7.84e-36 Type 2 diabetes; CRC cis rs875971 0.522 rs4718285 chr7:65292005 A/G cg18912574 chr7:65842487 NCRNA00174 0.33 5.64 0.3 3.58e-8 Aortic root size; CRC cis rs1256061 0.624 rs944046 chr14:64700299 G/A cg23250157 chr14:64679961 SYNE2 0.46 7.13 0.37 6.4e-12 Hemoglobin concentration;Red blood cell count;Hematocrit; CRC cis rs8060686 0.844 rs7196076 chr16:67887494 T/A cg08314208 chr16:67682810 RLTPR -0.61 -6.63 -0.34 1.37e-10 HDL cholesterol;Metabolic syndrome; CRC cis rs3096299 0.685 rs4238830 chr16:89540241 C/T cg02187348 chr16:89574699 SPG7 0.39 5.8 0.3 1.56e-8 Multiple myeloma (IgH translocation); CRC cis rs55665837 1.000 rs55665837 chr11:14495049 C/T cg19336497 chr11:14380999 RRAS2 -0.4 -6.75 -0.35 6.85e-11 Vitamin D levels; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg18548362 chr4:1857197 LETM1 0.38 6.34 0.33 7.52e-10 Liver disease severity in Alagille syndrome; CRC cis rs3820928 1.000 rs10193404 chr2:227777757 A/G cg11843606 chr2:227700838 RHBDD1 -0.42 -6.01 -0.31 4.84e-9 Pulmonary function; CRC cis rs6761276 0.649 rs10184259 chr2:113838628 T/C cg09040174 chr2:113837401 NA 0.58 9.05 0.45 1.31e-17 Protein quantitative trait loci; CRC cis rs10504229 1.000 rs61998258 chr8:58192284 T/C cg02290350 chr8:58132656 NA -0.42 -5.96 -0.31 6.62e-9 Developmental language disorder (linguistic errors); CRC cis rs6502050 0.871 rs8082577 chr17:80070581 T/C cg13198984 chr17:80129470 CCDC57 -0.46 -7.93 -0.4 3.38e-14 Life satisfaction; CRC cis rs4474465 0.850 rs10793324 chr11:78251485 C/T cg27205649 chr11:78285834 NARS2 -0.48 -6.14 -0.32 2.36e-9 Alzheimer's disease (survival time); CRC cis rs6831352 0.918 rs13138294 chr4:100062675 T/G cg12011299 chr4:100065546 ADH4 -0.5 -9.61 -0.47 1.95e-19 Alcohol dependence; CRC cis rs9311474 1.000 rs6445358 chr3:52308845 C/G cg08222913 chr3:52553049 STAB1 -0.37 -6.81 -0.35 4.61e-11 Electroencephalogram traits; CRC cis rs601339 1.000 rs630408 chr12:123172822 C/T cg25190513 chr12:123201362 GPR109B -0.5 -6.32 -0.33 8.41e-10 Adiponectin levels; CRC cis rs72634258 0.554 rs10462018 chr1:7879627 C/T cg26816564 chr1:7831052 VAMP3 0.8 9.27 0.45 2.6e-18 Inflammatory bowel disease; CRC cis rs4665809 1.000 rs6704930 chr2:26325705 G/A cg26119090 chr2:26468346 HADHA;HADHB -0.61 -7.88 -0.4 4.97e-14 Gut microbiome composition (summer); CRC cis rs6424115 0.830 rs3003336 chr1:24201448 C/T cg10978503 chr1:24200527 CNR2 0.61 11.06 0.52 2.22e-24 Immature fraction of reticulocytes; CRC cis rs10464366 0.544 rs1525799 chr7:39153131 C/G cg15212455 chr7:39170539 POU6F2 -0.47 -6.35 -0.33 7.18e-10 IgG glycosylation; CRC cis rs6502050 0.799 rs4789680 chr17:80100547 C/A cg11859384 chr17:80120422 CCDC57 -0.37 -5.85 -0.31 1.16e-8 Life satisfaction; CRC cis rs524281 1.000 rs524281 chr11:65886662 C/A cg14036092 chr11:66035641 RAB1B 0.5 6.84 0.35 3.83e-11 Electroencephalogram traits; CRC cis rs9467711 0.606 rs34781270 chr6:26593037 A/G cg16898833 chr6:26189333 HIST1H4D 1.14 8.46 0.42 8.89e-16 Autism spectrum disorder or schizophrenia; CRC cis rs4731207 0.596 rs12534466 chr7:124668423 A/G cg23710748 chr7:124431027 NA -0.38 -6.02 -0.32 4.58e-9 Cutaneous malignant melanoma; CRC cis rs2243480 1.000 rs58062456 chr7:65394852 G/T cg18252515 chr7:66147081 NA -1.08 -12.66 -0.57 3.44e-30 Diabetic kidney disease; CRC cis rs910316 0.503 rs12894709 chr14:75441734 G/A cg11812906 chr14:75593930 NEK9 0.48 7.19 0.37 4.25e-12 Height; CRC cis rs8005677 1.000 rs10148215 chr14:23382345 C/T cg01529538 chr14:23388837 RBM23 0.38 5.91 0.31 8.78e-9 Cognitive ability (multi-trait analysis); CRC cis rs11098499 0.657 rs9996569 chr4:120299004 G/C cg24375607 chr4:120327624 NA 0.51 7.86 0.4 5.5e-14 Corneal astigmatism; CRC trans rs2303319 0.504 rs12467613 chr2:162603216 G/T cg22627826 chr19:1240265 ATP5D -0.72 -6.24 -0.33 1.32e-9 Cognitive function; CRC cis rs6831352 0.918 rs13129488 chr4:100053025 G/T cg13256891 chr4:100009986 ADH5 -0.66 -8.89 -0.44 4.04e-17 Alcohol dependence; CRC cis rs5769765 0.908 rs9616388 chr22:50313438 T/C cg04121214 chr22:50244548 NA 0.41 5.79 0.3 1.68e-8 Schizophrenia; CRC cis rs2230307 0.505 rs482873 chr1:100589757 C/T cg24955406 chr1:100503596 HIAT1 -0.56 -6.74 -0.35 6.96e-11 Carotid intima media thickness; CRC trans rs7824557 0.564 rs11781637 chr8:11214972 C/T cg06636001 chr8:8085503 FLJ10661 -0.41 -5.96 -0.31 6.49e-9 Retinal vascular caliber; CRC cis rs1552244 1.000 rs6781811 chr3:10121922 A/G cg16606324 chr3:10149918 C3orf24 -0.71 -9.75 -0.47 6.72e-20 Alzheimer's disease; CRC trans rs6546324 0.580 rs4410279 chr2:67850620 A/C cg00907274 chr3:27498161 SLC4A7 -0.49 -6.26 -0.33 1.21e-9 Endometriosis; CRC cis rs1062746 0.528 rs891092 chr16:87338226 G/A cg02258303 chr16:87377426 FBXO31 -0.53 -8.19 -0.41 5.91e-15 Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 2 peripheral neuropathy); CRC cis rs12477438 0.501 rs6708878 chr2:99801564 G/A cg26064155 chr2:99771622 LIPT1;TSGA10 0.77 13.13 0.59 5.79e-32 Chronic sinus infection; CRC cis rs7811142 1.000 rs67040465 chr7:100083078 G/A cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.72 9.45 0.46 6.45e-19 Platelet count; CRC cis rs9916302 0.904 rs2061338 chr17:37421767 T/C cg07936489 chr17:37558343 FBXL20 -0.84 -13.08 -0.59 8.78e-32 Glomerular filtration rate (creatinine); CRC cis rs12999616 0.817 rs17695937 chr2:98327875 A/G cg26665480 chr2:98280029 ACTR1B 0.52 6.43 0.33 4.6e-10 Colorectal cancer; CRC trans rs2797160 1.000 rs1777194 chr6:126004883 G/A cg05039488 chr6:79577232 IRAK1BP1 -0.49 -7.2 -0.37 4.18e-12 Endometrial cancer; CRC cis rs2032447 0.670 rs198820 chr6:26124243 G/A cg18357526 chr6:26021779 HIST1H4A -0.69 -10.36 -0.5 6e-22 Intelligence (multi-trait analysis); CRC cis rs9400239 0.661 rs1268163 chr6:109008998 C/T cg11073813 chr6:109029018 NA -0.4 -6.23 -0.32 1.41e-9 Waist circumference;Body mass index;BMI (adjusted for smoking behaviour); CRC cis rs6951245 1.000 rs77868187 chr7:1093968 A/C cg04025307 chr7:1156635 C7orf50 0.64 6.81 0.35 4.54e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs3617 0.591 rs11918800 chr3:52868145 G/A cg18099408 chr3:52552593 STAB1 0.35 6.03 0.32 4.48e-9 Red blood cell count;Autism spectrum disorder or schizophrenia; CRC cis rs9527 0.544 rs3781280 chr10:104863843 T/G cg15744005 chr10:104629667 AS3MT -0.31 -6.05 -0.32 3.97e-9 Arsenic metabolism; CRC cis rs10256972 0.706 rs12701970 chr7:1121958 T/C cg16145915 chr7:1198662 ZFAND2A -0.4 -7.56 -0.38 4.08e-13 Longevity;Endometriosis; CRC trans rs12682352 0.652 rs1567398 chr8:8726804 A/C cg16141378 chr3:129829833 LOC729375 0.39 6.08 0.32 3.42e-9 Neuroticism; CRC cis rs9814567 1.000 rs9289478 chr3:134268619 A/G cg06541857 chr3:134203789 ANAPC13;CEP63 -0.38 -5.64 -0.3 3.64e-8 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs6504950 0.830 rs17817877 chr17:53034628 T/A cg26251398 chr17:52985966 TOM1L1 0.43 5.75 0.3 2.02e-8 Breast cancer; CRC cis rs7493 1.000 rs17876124 chr7:95045258 C/G cg07404485 chr7:94953653 PON1 -0.45 -5.94 -0.31 7.43e-9 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs9914988 0.943 rs9907178 chr17:27124307 G/C cg07195577 chr17:27052828 TLCD1 0.42 6.02 0.32 4.64e-9 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs1950500 0.550 rs7148384 chr14:24828814 C/T cg07162820 chr14:24837146 NFATC4 0.55 7.62 0.39 2.74e-13 Height; CRC cis rs4716602 0.622 rs57131976 chr7:156167072 A/C cg16983916 chr7:156159713 NA -0.33 -5.62 -0.3 4e-8 Anti-saccade response; CRC cis rs769267 0.930 rs10414830 chr19:19562332 C/T cg02546618 chr19:19431379 KIAA0892;SF4 0.46 6.38 0.33 6.05e-10 Tonsillectomy; CRC cis rs7811142 1.000 rs6972167 chr7:100080013 G/T cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.17 17.16 0.69 1.38e-47 Platelet count; CRC cis rs4474465 1.000 rs10899517 chr11:78180507 A/T cg27205649 chr11:78285834 NARS2 -0.48 -5.8 -0.3 1.57e-8 Alzheimer's disease (survival time); CRC cis rs2073300 0.609 rs2281434 chr20:23378101 C/A cg12062639 chr20:23401060 NAPB 0.74 6.78 0.35 5.43e-11 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs863345 0.584 rs1342949 chr1:158463295 C/T cg12129480 chr1:158549410 OR10X1 -0.3 -6.31 -0.33 8.84e-10 Pneumococcal bacteremia; CRC trans rs11098499 0.754 rs10212714 chr4:120254302 T/C cg25214090 chr10:38739885 LOC399744 0.52 7.93 0.4 3.44e-14 Corneal astigmatism; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg02437376 chr10:76969880 VDAC2 0.42 5.99 0.31 5.45e-9 Intelligence (multi-trait analysis); CRC cis rs6838801 0.588 rs344140 chr4:77660162 G/C cg17476223 chr4:77663285 SHROOM3 -0.43 -5.72 -0.3 2.43e-8 Cleft lip with or without cleft palate; CRC cis rs7705042 0.865 rs4912804 chr5:141493614 T/C cg08523384 chr5:141488047 NDFIP1 -0.33 -5.88 -0.31 9.9e-9 Asthma; CRC cis rs13108904 0.935 rs11247984 chr4:1292811 G/A cg19318889 chr4:1322082 MAEA 0.41 5.73 0.3 2.28e-8 Obesity-related traits; CRC cis rs597583 0.951 rs599411 chr11:117422262 T/G cg27161313 chr11:117392002 DSCAML1 -0.39 -5.75 -0.3 2.09e-8 Putamen volume; CRC trans rs11088226 0.681 rs2833926 chr21:33975279 A/G cg09050820 chr6:167586206 TCP10L2 0.85 8.83 0.44 6.23e-17 Gastritis; CRC cis rs4563143 0.647 rs117442062 chr19:29256823 A/T cg14983838 chr19:29218262 NA 0.47 6.82 0.35 4.42e-11 Methadone dose in opioid dependence; CRC cis rs7605827 0.930 rs12692261 chr2:15511967 T/G cg19274914 chr2:15703543 NA 0.38 5.79 0.3 1.62e-8 Educational attainment (years of education); CRC cis rs6089584 0.888 rs6061966 chr20:60607936 C/G cg13770153 chr20:60521292 NA -0.59 -8.82 -0.44 6.94e-17 Body mass index; CRC cis rs17384381 0.953 rs1498374 chr1:85787334 C/T cg16011679 chr1:85725395 C1orf52 0.65 6.54 0.34 2.39e-10 Lobe attachment (rater-scored or self-reported); CRC cis rs7659604 0.539 rs7660548 chr4:122730821 G/C cg19748678 chr4:122722346 EXOSC9 0.65 10.16 0.49 2.75e-21 Type 2 diabetes; CRC cis rs4692589 0.581 rs12646523 chr4:170944698 C/T cg19918862 chr4:170955249 NA 0.54 7.4 0.38 1.18e-12 Anxiety disorder; CRC cis rs2580764 0.540 rs10210840 chr2:55226009 G/A cg09592903 chr2:55203963 RTN4 -0.67 -10.94 -0.52 5.75e-24 Mean platelet volume; CRC cis rs9341808 0.667 rs3805919 chr6:80906809 C/G cg08355045 chr6:80787529 NA 0.33 5.68 0.3 2.89e-8 Sitting height ratio; CRC cis rs208520 0.690 rs12204512 chr6:66710486 C/T cg07460842 chr6:66804631 NA 1.04 14.54 0.63 2.35e-37 Exhaled nitric oxide output; CRC cis rs11971779 0.564 rs6467841 chr7:139066092 T/G cg07862535 chr7:139043722 LUC7L2 0.57 7.35 0.38 1.61e-12 Diisocyanate-induced asthma; CRC trans rs11148252 0.875 rs9526913 chr13:52975837 T/C cg18335740 chr13:41363409 SLC25A15 0.49 7.57 0.39 3.71e-13 Lewy body disease; CRC cis rs4803480 0.554 rs12150975 chr19:42070360 C/T cg08478046 chr19:42093086 CEACAM21 -0.28 -5.93 -0.31 7.55e-9 Schizophrenia; CRC cis rs2204008 0.728 rs12369538 chr12:38443942 C/T cg13010199 chr12:38710504 ALG10B 0.47 6.09 0.32 3.16e-9 Bladder cancer; CRC cis rs9303401 0.659 rs34170300 chr17:56789905 G/C cg02118635 chr17:56770003 RAD51C;TEX14 0.79 10.13 0.49 3.5e-21 Cognitive test performance; CRC cis rs9322193 0.923 rs6913486 chr6:150026196 C/T cg13206674 chr6:150067644 NUP43 -0.65 -9.39 -0.46 1.07e-18 Lung cancer; CRC cis rs66887589 0.592 rs62320740 chr4:120279486 C/A cg09307838 chr4:120376055 NA 0.6 9.33 0.46 1.67e-18 Diastolic blood pressure; CRC cis rs17376456 0.809 rs13177800 chr5:93307350 T/C cg21475434 chr5:93447410 FAM172A 0.78 7.84 0.4 6.45e-14 Diabetic retinopathy; CRC trans rs11098499 0.954 rs11098524 chr4:120390032 A/G cg25214090 chr10:38739885 LOC399744 0.66 10.31 0.49 8.56e-22 Corneal astigmatism; CRC cis rs10464366 0.544 rs12701697 chr7:39182165 C/T cg21665744 chr7:39171113 POU6F2 0.44 5.9 0.31 9.26e-9 IgG glycosylation; CRC cis rs4150161 0.656 rs2288026 chr16:84220344 C/G cg10106505 chr16:84220380 TAF1C 1.08 9.42 0.46 8.08e-19 Systolic blood pressure response to hydrochlorothiazide in hypertension; CRC cis rs7274811 0.901 rs55990870 chr20:32302908 C/T cg07470512 chr20:32255052 NECAB3;C20orf134 -0.5 -6.22 -0.32 1.51e-9 Height; CRC cis rs17376456 0.825 rs17372725 chr5:93135588 C/A cg21475434 chr5:93447410 FAM172A 0.72 7.33 0.37 1.77e-12 Diabetic retinopathy; CRC cis rs6570726 0.905 rs388728 chr6:145816419 T/C cg05347473 chr6:146136440 FBXO30 0.37 5.93 0.31 7.63e-9 Lobe attachment (rater-scored or self-reported); CRC trans rs16846053 0.786 rs72873645 chr2:162495047 G/A cg10272801 chr16:14013773 ERCC4 -0.67 -6.07 -0.32 3.6e-9 Blood osmolality (transformed sodium); CRC cis rs2440129 0.632 rs2292353 chr17:6903537 C/T cg25987502 chr17:6899865 ALOX12 0.36 6.67 0.35 1.1e-10 Tonsillectomy; CRC cis rs9303401 0.538 rs10515155 chr17:56481944 A/G cg02118635 chr17:56770003 RAD51C;TEX14 0.72 8.66 0.43 2.21e-16 Cognitive test performance; CRC cis rs7412746 0.503 rs72704639 chr1:150798335 A/C cg17724175 chr1:150552817 MCL1 0.44 6.96 0.36 1.82e-11 Melanoma; CRC cis rs7712401 0.755 rs1545697 chr5:122102277 T/C cg18764291 chr5:122110994 SNX2 0.42 6.68 0.35 1.03e-10 Mean platelet volume; CRC cis rs9515201 0.627 rs952359 chr13:111026734 G/A cg15455643 chr13:111040242 COL4A2 0.35 5.87 0.31 1.04e-8 White matter hyperintensity burden; CRC cis rs2739330 0.731 rs4822450 chr22:24242887 C/T cg11905131 chr22:24372483 LOC391322 -0.67 -10.38 -0.5 5.2e-22 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs6714710 0.603 rs10432626 chr2:98561153 C/A cg26665480 chr2:98280029 ACTR1B 0.53 7.45 0.38 8.15e-13 Posterior cortical atrophy and Alzheimer's disease; CRC cis rs801193 0.935 rs2659916 chr7:66151352 C/G cg18876405 chr7:65276391 NA 0.61 10.76 0.51 2.52e-23 Aortic root size; CRC cis rs9322193 0.923 rs9505826 chr6:149955048 A/G cg13206674 chr6:150067644 NUP43 0.65 9.76 0.47 6.33e-20 Lung cancer; CRC cis rs9942416 0.660 rs41534344 chr5:74997832 T/C cg00601450 chr5:74908170 NA 0.39 5.61 0.3 4.34e-8 Age-related disease endophenotypes; CRC cis rs72615157 0.613 rs56089143 chr7:99819844 G/A cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.46 5.78 0.3 1.77e-8 Lung function (FEV1/FVC); CRC cis rs7605827 0.930 rs11903302 chr2:15706286 C/T cg19274914 chr2:15703543 NA 0.38 5.81 0.31 1.48e-8 Educational attainment (years of education); CRC cis rs739401 0.572 rs739399 chr11:3016452 A/G cg25174290 chr11:3078921 CARS 0.45 7.1 0.36 7.79e-12 Longevity; CRC cis rs11105298 0.891 rs11105309 chr12:89909850 T/C cg00757033 chr12:89920650 WDR51B 0.36 6.13 0.32 2.46e-9 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; CRC trans rs1814175 0.669 rs11040473 chr11:49703813 C/T cg03929089 chr4:120376271 NA -0.76 -12.63 -0.57 4.22e-30 Height; CRC cis rs17780086 0.527 rs72827712 chr17:30538600 A/G cg00745463 chr17:30367425 LRRC37B -0.86 -8.13 -0.41 9.08e-15 Height; CRC cis rs12024301 0.557 rs10911388 chr1:183616781 G/T cg11505048 chr1:183622726 RGL1;APOBEC4 0.78 6.59 0.34 1.78e-10 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs9372498 0.536 rs9481808 chr6:118784571 G/A cg10217327 chr6:118973057 C6orf204 0.51 5.76 0.3 1.93e-8 Diastolic blood pressure; CRC cis rs9300255 0.739 rs12824957 chr12:123750228 T/C cg00376283 chr12:123451042 ABCB9 -0.55 -6.17 -0.32 2.02e-9 Neutrophil percentage of white cells; CRC cis rs9911578 1.000 rs2009948 chr17:56611920 A/C cg12560992 chr17:57184187 TRIM37 -0.91 -17.13 -0.69 1.81e-47 Intelligence (multi-trait analysis); CRC cis rs12580194 0.593 rs59676560 chr12:55745425 T/C cg19537932 chr12:55886519 OR6C68 -0.66 -8.56 -0.43 4.26e-16 Cancer; CRC cis rs826838 0.616 rs10880754 chr12:38628154 C/T cg26384229 chr12:38710491 ALG10B -0.53 -7.63 -0.39 2.48e-13 Heart rate; CRC cis rs11690935 1.000 rs1554166 chr2:172541609 G/T cg13550731 chr2:172543902 DYNC1I2 -1.07 -18.85 -0.72 2.83e-54 Schizophrenia; CRC trans rs2228479 0.850 rs11076623 chr16:89844120 G/T cg24644049 chr4:85504048 CDS1 0.92 7.68 0.39 1.79e-13 Skin colour saturation; CRC cis rs9291683 0.552 rs11736410 chr4:10017241 G/A cg11266682 chr4:10021025 SLC2A9 0.53 11.39 0.53 1.47e-25 Bone mineral density; CRC cis rs898097 0.607 rs2199111 chr17:80823203 A/G cg15369054 chr17:80825471 TBCD 0.34 5.74 0.3 2.15e-8 Breast cancer; CRC cis rs1862618 0.671 rs2591964 chr5:56236900 T/G cg20203395 chr5:56204925 C5orf35 0.56 7.62 0.39 2.75e-13 Initial pursuit acceleration; CRC cis rs7615952 0.599 rs67575510 chr3:125742355 C/G cg02772935 chr3:125709198 NA -0.5 -5.71 -0.3 2.53e-8 Blood pressure (smoking interaction); CRC trans rs10842750 1.000 rs10842750 chr12:26690565 G/T cg04778178 chr7:27162294 HOXA3 0.26 5.97 0.31 6.08e-9 Kashin-Beck disease; CRC cis rs6543140 0.964 rs918000 chr2:103067862 C/T cg09003973 chr2:102972529 NA 0.41 5.86 0.31 1.11e-8 Blood protein levels; CRC cis rs1799949 1.000 rs12944458 chr17:41180772 C/T cg23758822 chr17:41437982 NA 0.8 13.18 0.59 3.91e-32 Menopause (age at onset); CRC cis rs6062302 0.548 rs4809310 chr20:62228745 G/A cg06363034 chr20:62225388 GMEB2 -0.45 -6.88 -0.35 2.94e-11 Glioblastoma; CRC cis rs6121246 0.609 rs6060843 chr20:30297047 G/C cg13852791 chr20:30311386 BCL2L1 0.72 14.0 0.61 2.87e-35 Mean corpuscular hemoglobin; CRC cis rs10504229 1.000 rs17805602 chr8:58179915 A/G cg02290350 chr8:58132656 NA -0.42 -5.96 -0.31 6.62e-9 Developmental language disorder (linguistic errors); CRC cis rs2243480 1.000 rs316318 chr7:65612904 A/G cg18252515 chr7:66147081 NA -1.27 -14.59 -0.63 1.57e-37 Diabetic kidney disease; CRC cis rs992157 0.710 rs10169718 chr2:219103580 C/T cg00012203 chr2:219082015 ARPC2 -0.63 -10.43 -0.5 3.38e-22 Colorectal cancer; CRC cis rs6121246 0.559 rs6119650 chr20:30258480 C/A cg13852791 chr20:30311386 BCL2L1 0.7 13.25 0.59 2.06e-32 Mean corpuscular hemoglobin; CRC cis rs1348850 0.914 rs6710575 chr2:178377311 C/T cg22681709 chr2:178499509 PDE11A -0.39 -7.07 -0.36 9.53e-12 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs73206853 0.620 rs73194027 chr12:111144317 C/A cg12870014 chr12:110450643 ANKRD13A 0.67 6.48 0.34 3.4e-10 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC trans rs1814175 0.935 rs7950947 chr11:49668369 C/T cg15704280 chr7:45808275 SEPT13 -0.98 -18.41 -0.71 1.63e-52 Height; CRC cis rs853679 1.000 rs2799077 chr6:28234597 C/T cg15786705 chr6:28176104 NA 0.58 6.15 0.32 2.29e-9 Depression; CRC cis rs7666738 0.830 rs7659420 chr4:98878714 G/C cg17366294 chr4:99064904 C4orf37 0.42 6.9 0.36 2.61e-11 Colonoscopy-negative controls vs population controls; CRC trans rs12744310 0.887 rs72667610 chr1:41794810 G/A cg19175123 chr10:103411746 FBXW4 0.46 6.13 0.32 2.55e-9 Cognitive ability (multi-trait analysis);Intelligence;Cognitive ability; CRC cis rs1656402 0.953 rs1190456 chr2:233435104 T/C cg03852847 chr2:233439513 NA -0.42 -6.85 -0.35 3.73e-11 Non-small cell lung cancer (survival); CRC cis rs6141769 0.542 rs6058840 chr20:31319116 A/T cg13636640 chr20:31349939 DNMT3B 0.42 6.05 0.32 3.93e-9 Subjective well-being; CRC cis rs875971 0.522 rs4718285 chr7:65292005 A/G cg00343986 chr7:65444356 GUSB 0.56 8.49 0.42 6.99e-16 Aortic root size; CRC cis rs501120 0.584 rs10900000 chr10:44694892 G/A cg09554077 chr10:44749378 NA 0.71 7.85 0.4 5.98e-14 Coronary artery disease;Coronary heart disease; CRC cis rs7552404 0.807 rs2066183 chr1:76153745 A/G cg22875332 chr1:76189707 ACADM 0.76 11.12 0.52 1.37e-24 Blood metabolite levels;Acylcarnitine levels; CRC cis rs1153858 0.725 rs74572151 chr15:45647526 T/G cg10760299 chr15:45669010 GATM 0.49 7.81 0.4 7.8500000000000006e-14 Homoarginine levels; CRC trans rs11466653 1.000 rs9998678 chr4:38777520 T/A cg11403706 chr22:49042600 FAM19A5 0.62 6.11 0.32 2.76e-9 Peripheral arterial disease (traffic-related air pollution interaction); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg14640712 chr21:45526961 PWP2 0.43 6.37 0.33 6.24e-10 Intelligence (multi-trait analysis); CRC cis rs2243480 1.000 rs56016656 chr7:65383481 C/T cg12463550 chr7:65579703 CRCP 0.69 6.47 0.34 3.5e-10 Diabetic kidney disease; CRC trans rs10242455 0.702 rs74416635 chr7:99180569 G/A cg09045935 chr12:6379348 NA 1.15 8.87 0.44 4.69e-17 Blood metabolite levels; CRC trans rs1814175 0.817 rs1621090 chr11:49895868 C/A cg11707556 chr5:10655725 ANKRD33B -0.44 -8.43 -0.42 1.12e-15 Height; CRC cis rs425277 0.606 rs262669 chr1:2082489 A/G cg12639453 chr1:2035780 PRKCZ -0.3 -5.6 -0.3 4.47e-8 Height; CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg13393204 chr11:86748738 TMEM135 0.44 7.39 0.38 1.25e-12 Obesity-related traits; CRC cis rs909674 0.865 rs5757682 chr22:39848259 T/G cg05872129 chr22:39784769 NA -0.47 -8.22 -0.41 4.84e-15 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; CRC cis rs7827545 1.000 rs7008121 chr8:135565904 T/C cg07299736 chr8:135490787 ZFAT -0.37 -6.19 -0.32 1.77e-9 Hypertension (SNP x SNP interaction); CRC cis rs4819052 0.851 rs2255774 chr21:46683851 A/T cg02159808 chr21:46707872 POFUT2;LOC642852 0.44 5.97 0.31 6.15e-9 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs1862618 0.671 rs2034244 chr5:56242774 T/C cg24531977 chr5:56204891 C5orf35 0.66 10.19 0.49 2.19e-21 Initial pursuit acceleration; CRC cis rs2346160 0.831 rs1467391 chr6:167690062 A/G cg04673565 chr6:167680447 NA -0.41 -6.79 -0.35 5.22e-11 Parental extreme longevity (95 years and older); CRC cis rs2228479 0.850 rs1800344 chr16:89816367 T/G cg19635926 chr16:89946313 TCF25 0.66 5.97 0.31 6.1e-9 Skin colour saturation; CRC cis rs10256972 0.568 rs1133043 chr7:1133305 C/G cg03188948 chr7:1209495 NA 0.45 6.43 0.33 4.53e-10 Longevity;Endometriosis; CRC trans rs2243480 1.000 rs958550 chr7:65635679 C/T cg10756647 chr7:56101905 PSPH -0.73 -7.84 -0.4 6.49e-14 Diabetic kidney disease; CRC cis rs2153535 0.580 rs7753192 chr6:8482637 G/A cg07606381 chr6:8435919 SLC35B3 0.68 10.91 0.52 7.61e-24 Motion sickness; CRC trans rs6951245 1.000 rs75016635 chr7:1094121 G/A cg13565492 chr6:43139072 SRF -0.72 -7.46 -0.38 7.73e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs6499255 0.762 rs12325186 chr16:69658807 A/T cg04110750 chr16:69646130 NFAT5 -0.58 -7.54 -0.38 4.6e-13 IgE levels; CRC cis rs10463316 0.779 rs6896444 chr5:150777357 T/G cg03212797 chr5:150827313 SLC36A1 -0.46 -7.14 -0.37 5.85e-12 Metabolite levels (Pyroglutamine); CRC cis rs4319547 0.915 rs7966094 chr12:123115771 A/G cg05707623 chr12:122985044 ZCCHC8 -0.77 -9.34 -0.46 1.55e-18 Body mass index; CRC cis rs1862618 0.641 rs2591954 chr5:56245044 G/C cg20203395 chr5:56204925 C5orf35 0.58 8.0 0.4 2.11e-14 Initial pursuit acceleration; CRC cis rs6951245 1.000 rs77702926 chr7:1088838 G/A cg20603222 chr7:1096387 C7orf50;GPR146 -0.73 -8.49 -0.42 7.07e-16 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg15947007 chr7:64023509 ZNF680 0.43 6.78 0.35 5.55e-11 Liver disease severity in Alagille syndrome; CRC cis rs2153535 0.580 rs1119688 chr6:8460850 T/C cg07606381 chr6:8435919 SLC35B3 0.67 10.71 0.51 3.63e-23 Motion sickness; CRC cis rs344364 0.511 rs2982447 chr16:1947413 C/T cg09830162 chr16:1889614 FAHD1;C16orf73 0.75 9.13 0.45 7.08e-18 Glomerular filtration rate in chronic kidney disease; CRC cis rs1707322 0.686 rs61784833 chr1:46233772 T/C cg06784218 chr1:46089804 CCDC17 0.65 12.23 0.56 1.36e-28 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs758324 0.947 rs28537859 chr5:131237277 C/G cg06307176 chr5:131281290 NA -0.43 -6.24 -0.33 1.34e-9 Alzheimer's disease in APOE e4- carriers; CRC cis rs12143943 0.934 rs12567161 chr1:204577832 G/A cg17419461 chr1:204415978 PIK3C2B 0.37 5.76 0.3 1.95e-8 Cognitive performance; CRC cis rs3733585 0.637 rs6850684 chr4:9964380 G/T cg00071950 chr4:10020882 SLC2A9 -0.55 -9.79 -0.47 5.05e-20 Cleft plate (environmental tobacco smoke interaction); CRC cis rs4731207 0.698 rs3919896 chr7:124553007 A/T cg23710748 chr7:124431027 NA -0.37 -6.0 -0.31 5.3300000000000004e-09 Cutaneous malignant melanoma; CRC cis rs951366 0.789 rs7536483 chr1:205718858 A/T cg26354017 chr1:205819088 PM20D1 0.73 11.0 0.52 3.69e-24 Menarche (age at onset); CRC cis rs12701220 0.817 rs1058727 chr7:1087095 A/G cg26240231 chr7:1148101 C7orf50 -0.37 -5.66 -0.3 3.39e-8 Bronchopulmonary dysplasia; CRC cis rs554111 0.963 rs666371 chr1:21041555 A/G cg08890418 chr1:21044141 KIF17 0.32 5.98 0.31 5.88e-9 Facial morphology (factor 17, height of vermillion upper lip); CRC cis rs939658 0.935 rs34859518 chr15:79450422 A/G cg17916960 chr15:79447300 NA -0.45 -7.49 -0.38 6.37e-13 Refractive error; CRC cis rs6062302 0.534 rs1556456 chr20:62216289 T/C cg16989086 chr20:62203971 PRIC285 0.46 5.83 0.31 1.31e-8 Glioblastoma; CRC cis rs9611565 0.659 rs28623192 chr22:41940524 A/G cg06481639 chr22:41940642 POLR3H -0.51 -5.91 -0.31 8.77e-9 Vitiligo; CRC cis rs4664308 0.618 rs17830940 chr2:160891768 T/C cg03641300 chr2:160917029 PLA2R1 -0.55 -8.28 -0.42 3.06e-15 Idiopathic membranous nephropathy; CRC cis rs28386778 0.863 rs9897229 chr17:61782325 T/C cg22520471 chr17:61851767 DDX42;CCDC47 0.71 10.5 0.5 1.96e-22 Prudent dietary pattern; CRC cis rs881375 0.967 rs10435843 chr9:123668033 A/G cg09419670 chr9:123605666 PSMD5;LOC253039 0.6 8.81 0.44 7.32e-17 Rheumatoid arthritis; CRC cis rs7726839 0.574 rs72705017 chr5:623733 G/A cg17948913 chr5:572064 NA 0.51 5.89 0.31 9.53e-9 Obesity-related traits; CRC cis rs651907 0.557 rs11917682 chr3:101355427 G/A cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.64 8.62 0.43 2.86e-16 Colorectal cancer; CRC cis rs7659604 1.000 rs28532673 chr4:122664323 A/G cg20573242 chr4:122745356 CCNA2 -0.42 -6.32 -0.33 8.59e-10 Type 2 diabetes; CRC cis rs877282 1.000 rs12779159 chr10:772143 T/C cg17470449 chr10:769945 NA 0.63 8.43 0.42 1.11e-15 Uric acid levels; CRC cis rs172166 0.516 rs1225715 chr6:28113373 C/T cg21251018 chr6:28226885 NKAPL -0.52 -8.82 -0.44 6.72e-17 Cardiac Troponin-T levels; CRC cis rs1003719 0.715 rs2835649 chr21:38552230 C/T cg10648535 chr21:38446584 PIGP;TTC3 0.48 6.63 0.34 1.37e-10 Eye color traits; CRC cis rs7119 0.634 rs11635634 chr15:77863412 T/C cg27398640 chr15:77910606 LINGO1 0.44 7.68 0.39 1.88e-13 Type 2 diabetes; CRC cis rs4604732 0.631 rs11490198 chr1:247625703 A/G cg12754571 chr1:247694271 LOC148824;OR2C3 0.41 5.78 0.3 1.74e-8 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CRC cis rs17826219 0.706 rs2322197 chr17:29105805 T/C cg01831904 chr17:28903510 LRRC37B2 -0.62 -6.52 -0.34 2.69e-10 Body mass index; CRC cis rs2976388 0.507 rs7813604 chr8:143838062 G/A cg24046110 chr8:143859143 LYNX1 0.62 10.81 0.51 1.67e-23 Urinary tract infection frequency; CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg16098923 chr2:88927231 EIF2AK3 0.38 6.41 0.33 5.14e-10 Obesity-related traits; CRC cis rs3791406 1.000 rs3791405 chr2:240030284 G/A cg14550559 chr2:240039617 HDAC4 -0.52 -7.81 -0.4 7.89e-14 Skin aging (microtopography measurement); CRC cis rs9311474 0.629 rs11709284 chr3:52559705 G/A cg15147215 chr3:52552868 STAB1 -0.78 -15.97 -0.66 6.82e-43 Electroencephalogram traits; CRC cis rs4481887 1.000 rs4244183 chr1:248471222 G/A cg00666640 chr1:248458726 OR2T12 0.52 9.19 0.45 4.48e-18 Common traits (Other); CRC cis rs4423214 0.840 rs1792233 chr11:71182179 G/A cg13043300 chr11:71146211 DHCR7 -0.44 -5.94 -0.31 7.26e-9 Vitamin D levels; CRC cis rs10479542 0.752 rs12658664 chr5:178986987 C/T cg09060608 chr5:178986726 RUFY1 0.55 9.42 0.46 8.34e-19 Lung cancer; CRC cis rs6582630 0.519 rs8186992 chr12:38325848 C/T cg26384229 chr12:38710491 ALG10B 0.67 9.53 0.47 3.52e-19 Drug-induced liver injury (flucloxacillin); CRC cis rs9549367 0.826 rs1885688 chr13:113894236 G/T cg18105134 chr13:113819100 PROZ -0.74 -11.24 -0.53 4.83e-25 Platelet distribution width; CRC trans rs4667466 0.727 rs12622595 chr2:163661011 A/G cg06147758 chr7:100487180 UFSP1 -0.51 -6.31 -0.33 8.84e-10 Diabetic kidney disease; CRC cis rs1707322 1.000 rs785519 chr1:46568562 C/T cg06784218 chr1:46089804 CCDC17 -0.55 -9.67 -0.47 1.26e-19 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs28655083 0.785 rs7404856 chr16:77130339 A/C cg01753188 chr16:77233325 SYCE1L;MON1B 0.57 7.84 0.4 6.47e-14 Lobe attachment (rater-scored or self-reported); CRC cis rs9611565 0.694 rs5758368 chr22:41862288 C/T cg03806693 chr22:41940476 POLR3H -1.08 -14.96 -0.64 5.87e-39 Vitiligo; CRC cis rs875971 0.862 rs4236208 chr7:65749078 C/T cg00343986 chr7:65444356 GUSB -0.4 -5.68 -0.3 2.97e-8 Aortic root size; CRC cis rs7618501 0.521 rs6774354 chr3:49961780 G/A cg05623727 chr3:50126028 RBM5 0.58 10.03 0.48 7.71e-21 Intelligence (multi-trait analysis); CRC trans rs208520 1.000 rs72884033 chr6:66995747 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.91 11.06 0.52 2.21e-24 Exhaled nitric oxide output; CRC cis rs939574 0.790 rs2385397 chr2:220087796 G/T cg00496455 chr2:220118770 TUBA4A;TUBA4B -0.88 -8.43 -0.42 1.06e-15 Platelet distribution width; CRC cis rs644799 1.000 rs546809 chr11:95579938 A/G cg25622487 chr11:95524042 FAM76B;CEP57 0.76 11.89 0.55 2.39e-27 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs9868809 0.656 rs73078362 chr3:48703917 G/C cg07636037 chr3:49044803 WDR6 -0.81 -5.71 -0.3 2.55e-8 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; CRC cis rs11122272 0.766 rs2790872 chr1:231540543 A/T cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.56 -8.28 -0.42 3.08e-15 Hemoglobin concentration; CRC cis rs34172651 0.517 rs874484 chr16:24803242 T/C cg00339695 chr16:24857497 SLC5A11 0.38 7.14 0.37 5.93e-12 Intelligence (multi-trait analysis); CRC cis rs4319547 0.695 rs10734915 chr12:122873408 A/C cg23029597 chr12:123009494 RSRC2 -0.53 -6.58 -0.34 1.8e-10 Body mass index; CRC cis rs9928842 0.770 rs4888364 chr16:75279510 A/G cg08657710 chr16:75258780 CTRB1 -0.54 -6.35 -0.33 7.2e-10 Alcoholic chronic pancreatitis; CRC cis rs4713118 0.662 rs9468277 chr6:28028390 C/A cg25164649 chr6:28176230 NA 0.65 8.58 0.43 3.87e-16 Parkinson's disease; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg00668182 chr20:30795591 POFUT1;PLAGL2 0.41 6.06 0.32 3.81e-9 Response to antipsychotic treatment; CRC trans rs7395662 1.000 rs4882134 chr11:48598795 A/C cg21153622 chr11:89784906 NA -0.48 -7.74 -0.39 1.26e-13 HDL cholesterol; CRC cis rs870825 0.655 rs35764203 chr4:185639078 C/A cg04058563 chr4:185651563 MLF1IP 0.73 9.54 0.47 3.37e-19 Blood protein levels; CRC cis rs55692411 0.537 rs71326904 chr3:49991060 C/T cg05623727 chr3:50126028 RBM5 0.53 6.97 0.36 1.71e-11 Intelligence (multi-trait analysis); CRC cis rs9322193 0.923 rs7769101 chr6:150169904 C/A cg00933542 chr6:150070202 PCMT1 0.28 5.71 0.3 2.51e-8 Lung cancer; CRC cis rs7312933 0.558 rs1796394 chr12:42826359 G/A cg11827402 chr12:42719852 PPHLN1;ZCRB1 -0.66 -9.77 -0.47 5.6e-20 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CRC cis rs769267 0.930 rs2304098 chr19:19646272 T/C cg02546618 chr19:19431379 KIAA0892;SF4 0.44 6.01 0.31 4.89e-9 Tonsillectomy; CRC cis rs367943 0.966 rs364738 chr5:112808329 A/G cg12552261 chr5:112820674 MCC -0.5 -7.78 -0.39 9.28e-14 Type 2 diabetes; CRC cis rs501120 0.810 rs498810 chr10:44740776 A/C cg09554077 chr10:44749378 NA 0.89 13.18 0.59 3.84e-32 Coronary artery disease;Coronary heart disease; CRC cis rs8062405 0.558 rs231976 chr16:28545587 C/G cg05139728 chr16:28306816 SBK1 -0.32 -5.72 -0.3 2.43e-8 Cognitive ability (multi-trait analysis);Cognitive ability; CRC cis rs6424115 0.830 rs2503002 chr1:24196957 C/G cg10978503 chr1:24200527 CNR2 0.61 11.36 0.53 1.92e-25 Immature fraction of reticulocytes; CRC cis rs12889267 0.722 rs2319625 chr14:21565146 C/T cg02988727 chr14:21567520 ZNF219;C14orf176 0.46 6.93 0.36 2.24e-11 Hematocrit;Resting heart rate; CRC cis rs11608355 0.515 rs11611012 chr12:109945203 G/A cg05360138 chr12:110035743 NA 0.73 7.13 0.37 6.38e-12 Neuroticism; CRC cis rs66887589 0.967 rs1480933 chr4:120433248 C/T cg09307838 chr4:120376055 NA 0.52 8.01 0.4 1.95e-14 Diastolic blood pressure; CRC cis rs12230513 0.732 rs61547125 chr12:55814082 C/G cg19537932 chr12:55886519 OR6C68 -0.74 -9.46 -0.46 5.95e-19 Contrast sensitivity; CRC cis rs6951245 0.938 rs11764937 chr7:1092074 C/T cg24642844 chr7:1081250 C7orf50 -0.79 -9.79 -0.48 4.93e-20 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs7617773 0.925 rs35942721 chr3:48173069 C/T cg11946769 chr3:48343235 NME6 0.69 8.76 0.43 1.04e-16 Coronary artery disease; CRC cis rs3820068 0.603 rs6429767 chr1:15963334 G/A cg24675056 chr1:15929824 NA 0.51 7.06 0.36 9.73e-12 Systolic blood pressure; CRC cis rs270601 0.739 rs3900945 chr5:131592870 T/C cg04518342 chr5:131593106 PDLIM4 0.54 10.11 0.49 4.27e-21 Acylcarnitine levels; CRC cis rs2160860 0.965 rs2543049 chr8:39820209 C/T cg11363097 chr8:39792086 IDO2 -0.35 -5.65 -0.3 3.51e-8 Blood metabolite levels; CRC cis rs1223397 0.651 rs202017 chr6:13301051 C/G cg20827128 chr6:13274284 PHACTR1 0.37 5.69 0.3 2.8e-8 Blood pressure; CRC cis rs28386778 0.863 rs6919 chr17:61909485 A/T cg06873352 chr17:61820015 STRADA -0.76 -14.26 -0.62 2.84e-36 Prudent dietary pattern; CRC cis rs5753618 0.539 rs4820962 chr22:31689951 A/G cg07713946 chr22:31675144 LIMK2 -0.41 -5.78 -0.3 1.69e-8 Colorectal cancer; CRC cis rs7216064 0.953 rs1599859 chr17:65837193 C/G cg12091567 chr17:66097778 LOC651250 -0.62 -7.82 -0.4 7.46e-14 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CRC cis rs7119 0.635 rs2667767 chr15:77876031 T/C cg10437265 chr15:77819839 NA -0.49 -8.18 -0.41 6.44e-15 Type 2 diabetes; CRC cis rs6674176 0.660 rs3791112 chr1:44379248 T/G cg13606994 chr1:44402422 ARTN -0.37 -6.22 -0.32 1.49e-9 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Cognitive ability; CRC cis rs12142240 0.659 rs17361873 chr1:46832686 A/G cg14993813 chr1:46806288 NSUN4 -0.49 -6.26 -0.33 1.21e-9 Menopause (age at onset); CRC trans rs561341 0.609 rs739800 chr17:30190083 T/A cg20587970 chr11:113659929 NA 0.69 8.73 0.43 1.34e-16 Hip circumference adjusted for BMI; CRC cis rs7705042 0.861 rs6860138 chr5:141509985 G/A cg08523384 chr5:141488047 NDFIP1 -0.32 -5.77 -0.3 1.87e-8 Asthma; CRC trans rs7824557 0.564 rs2736293 chr8:11234613 T/A cg06636001 chr8:8085503 FLJ10661 -0.45 -6.85 -0.35 3.69e-11 Retinal vascular caliber; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg12214673 chr3:196159430 UBXN7 0.4 6.13 0.32 2.49e-9 Liver disease severity in Alagille syndrome; CRC cis rs875971 0.660 rs13224319 chr7:66007363 A/G cg18876405 chr7:65276391 NA 0.61 10.95 0.52 5.43e-24 Aortic root size; CRC cis rs3820068 0.603 rs998032 chr1:15989918 T/C cg27534772 chr1:16042836 PLEKHM2 0.55 10.42 0.5 3.63e-22 Systolic blood pressure; CRC cis rs9287719 0.967 rs6712304 chr2:10754375 A/C cg00105475 chr2:10696890 NA 0.45 7.17 0.37 4.86e-12 Prostate cancer; CRC cis rs8141529 0.748 rs132533 chr22:29299571 A/G cg15103426 chr22:29168792 CCDC117 -0.48 -6.58 -0.34 1.88e-10 Lymphocyte counts; CRC cis rs863345 0.604 rs1112915 chr1:158444447 T/C cg12129480 chr1:158549410 OR10X1 -0.3 -6.24 -0.33 1.35e-9 Pneumococcal bacteremia; CRC cis rs951366 0.789 rs823110 chr1:205701078 G/C cg07157834 chr1:205819609 PM20D1 0.77 11.67 0.54 1.44e-26 Menarche (age at onset); CRC cis rs1129187 0.719 rs3805953 chr6:42936900 C/T cg02359409 chr6:42947317 PEX6 -0.67 -10.75 -0.51 2.72e-23 Alzheimer's disease in APOE e4+ carriers; CRC cis rs7071206 1.000 rs7071206 chr10:79401316 C/T cg07817648 chr10:79422355 NA 0.69 9.78 0.47 5.24e-20 Bone mineral density; CRC cis rs4812048 0.649 rs3761257 chr20:57618787 C/T cg14073986 chr20:57617431 SLMO2 0.52 5.74 0.3 2.2e-8 Mean platelet volume; CRC cis rs2276314 0.857 rs28375959 chr18:33601534 T/G cg19628046 chr18:33552617 C18orf21 0.55 7.18 0.37 4.71e-12 Endometriosis;Drug-induced torsades de pointes; CRC cis rs9733 0.596 rs2275236 chr1:150669952 A/G cg18016565 chr1:150552671 MCL1 -0.46 -6.55 -0.34 2.28e-10 Tonsillectomy; CRC cis rs2836950 0.565 rs2836926 chr21:40536790 G/A cg17971929 chr21:40555470 PSMG1 -0.58 -8.64 -0.43 2.49e-16 Menarche (age at onset); CRC cis rs7998202 0.667 rs282579 chr13:113358436 G/C cg04656015 chr13:113407548 ATP11A -0.49 -5.68 -0.3 2.99e-8 Glycated hemoglobin levels; CRC cis rs9303401 0.646 rs7217845 chr17:57236900 G/A cg10487724 chr17:56770010 TEX14;RAD51C 0.43 6.41 0.33 5.15e-10 Cognitive test performance; CRC cis rs146201400 1 rs146201400 chr1:26645955 G/GA cg04990556 chr1:26633338 UBXN11 -0.46 -5.74 -0.3 2.2e-8 Monocyte percentage of white cells; CRC cis rs6088580 0.634 rs6088498 chr20:33020446 A/G cg08999081 chr20:33150536 PIGU 0.58 10.66 0.51 5.53e-23 Glomerular filtration rate (creatinine); CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg16725050 chr2:220117771 TUBA4B;TUBA4A 0.37 5.99 0.31 5.41e-9 Obesity-related traits; CRC cis rs1862618 0.853 rs832578 chr5:56164223 C/T cg20203395 chr5:56204925 C5orf35 -0.69 -8.03 -0.4 1.75e-14 Initial pursuit acceleration; CRC cis rs6762 0.719 rs28620453 chr11:836971 G/C cg07691484 chr11:842764 TSPAN4;POLR2L -0.56 -8.31 -0.42 2.61e-15 Mean platelet volume; CRC cis rs9314323 0.862 rs3808580 chr8:26250296 C/T cg13160058 chr8:26243215 BNIP3L 0.47 8.28 0.42 3.24e-15 Red cell distribution width; CRC cis rs733592 0.929 rs4760678 chr12:48461581 T/C cg21466736 chr12:48725269 NA 0.47 7.37 0.38 1.4e-12 Plateletcrit; CRC cis rs3857067 0.740 rs6532470 chr4:95108211 C/G cg11021082 chr4:95130006 SMARCAD1 -0.5 -7.82 -0.4 7.01e-14 QT interval; CRC cis rs12908161 0.960 rs17599989 chr15:85285536 A/G cg17507749 chr15:85114479 UBE2QP1 0.63 9.36 0.46 1.31e-18 Schizophrenia; CRC cis rs10779751 0.770 rs1417131 chr1:11191922 T/C cg08854313 chr1:11322531 MTOR -0.6 -7.51 -0.38 5.77e-13 Body mass index; CRC cis rs459193 0.912 rs27984 chr5:55802419 C/T cg18302225 chr5:55776401 NA 0.59 8.67 0.43 1.98e-16 Coronary artery disease;Type 2 diabetes;Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);Waist-to-hip ratio adjusted for BMI in non-smokers;Waist-to-hip ratio adjusted for BMI (smoking interaction);Waist-to-hip ratio adjusted for body mass index;Waist-hip ratio;Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction); CRC cis rs3796352 1.000 rs11710707 chr3:52975916 A/G cg27565382 chr3:53032988 SFMBT1 0.77 6.23 0.32 1.41e-9 Immune reponse to smallpox (secreted IL-2); CRC cis rs6963495 0.510 rs73192157 chr7:105225862 A/T cg02135003 chr7:105160482 PUS7 -0.72 -7.76 -0.39 1.11e-13 Bipolar disorder (body mass index interaction); CRC cis rs826838 0.838 rs11183646 chr12:38799846 A/T cg26384229 chr12:38710491 ALG10B 0.75 10.46 0.5 2.69e-22 Heart rate; CRC cis rs1696756 1.000 rs1696756 chr17:77827973 C/T cg00646381 chr17:77835854 NA 0.37 6.77 0.35 5.8e-11 Glucocorticoid-induced osteonecrosis (age 10 years and older); CRC cis rs72781680 0.898 rs72786288 chr2:24075416 G/T cg08917208 chr2:24149416 ATAD2B 0.93 9.54 0.47 3.27e-19 Lymphocyte counts; CRC cis rs9858542 0.953 rs11715915 chr3:49455330 A/G cg07274523 chr3:49395745 GPX1 -0.43 -5.86 -0.31 1.12e-8 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs1267303 0.675 rs2476164 chr1:46985274 T/C cg08533674 chr1:46993347 NA 0.6 7.96 0.4 2.9e-14 Monobrow; CRC trans rs4263408 0.934 rs9683743 chr4:39703194 A/C cg02567788 chr10:71992279 PPA1 -0.44 -6.44 -0.33 4.27e-10 Plasma amyloid beta peptide concentrations (ABx-40); CRC cis rs4713118 0.619 rs200486 chr6:27779506 C/T cg03623178 chr6:28175578 NA 0.58 6.4 0.33 5.28e-10 Parkinson's disease; CRC cis rs28374715 0.783 rs11635269 chr15:41570710 A/G cg18705301 chr15:41695430 NDUFAF1 -1.04 -17.23 -0.69 7.44e-48 Ulcerative colitis; CRC trans rs12599106 0.660 rs12919333 chr16:34991336 C/T cg01516881 chr6:292596 DUSP22 -0.64 -9.29 -0.46 2.17e-18 Menopause (age at onset); CRC cis rs3858526 0.883 rs1453429 chr11:5933478 C/T cg13902645 chr11:5959945 NA -0.61 -8.43 -0.42 1.09e-15 DNA methylation (variation); CRC cis rs597583 0.664 rs4938395 chr11:117384673 C/T cg27161313 chr11:117392002 DSCAML1 0.46 6.03 0.32 4.34e-9 Putamen volume; CRC cis rs7726839 0.540 rs56325086 chr5:640728 G/A cg16447950 chr5:562315 NA -0.74 -9.75 -0.47 6.56e-20 Obesity-related traits; CRC cis rs11030122 0.702 rs12286710 chr11:3967171 T/G cg18678763 chr11:4115507 RRM1 -0.49 -8.14 -0.41 8.51e-15 Mean platelet volume;Platelet distribution width; CRC cis rs34172651 0.517 rs200526 chr16:24760511 C/T cg06505273 chr16:24850292 NA -0.52 -6.74 -0.35 7.17e-11 Intelligence (multi-trait analysis); CRC cis rs2976388 0.507 rs7813604 chr8:143838062 G/A cg04969067 chr8:143858791 LYNX1 0.59 10.11 0.49 4.25e-21 Urinary tract infection frequency; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg23102962 chr12:110011481 MMAB;MVK 0.51 7.31 0.37 1.99e-12 Response to antipsychotic treatment; CRC cis rs3806843 0.966 rs6891559 chr5:140145206 G/A cg19875535 chr5:140030758 IK 0.61 10.01 0.48 9.04e-21 Depressive symptoms (multi-trait analysis); CRC cis rs9443189 0.570 rs775072 chr6:76377998 G/A cg01950844 chr6:76311363 SENP6 -0.74 -9.84 -0.48 3.35e-20 Prostate cancer; CRC trans rs8098244 0.708 rs1262340 chr18:21475153 A/G cg15462349 chr14:37116296 NA 0.49 6.0 0.31 5.23e-9 Epithelial ovarian cancer;Low-grade serous and serous borderline ovarian cancer;Serous borderline ovarian cancer; CRC cis rs6866614 0.608 rs17132288 chr5:131336105 C/T cg22638593 chr5:131593259 PDLIM4 0.31 5.66 0.3 3.25e-8 Perceived unattractiveness to mosquitoes; CRC cis rs1707322 1.000 rs6676982 chr1:46275401 A/T cg06784218 chr1:46089804 CCDC17 0.51 8.99 0.44 1.92e-17 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs896854 0.654 rs10104909 chr8:95977973 C/T cg23172400 chr8:95962367 TP53INP1 -0.46 -7.77 -0.39 1.03e-13 Type 2 diabetes; CRC cis rs11190604 1.000 rs11190596 chr10:102293238 C/G cg16342193 chr10:102329863 NA -0.38 -6.02 -0.31 4.68e-9 Palmitoleic acid (16:1n-7) levels; CRC cis rs7312774 0.618 rs9651926 chr12:107356820 G/A cg16260113 chr12:107380972 MTERFD3 0.97 9.26 0.45 2.8e-18 Severe influenza A (H1N1) infection; CRC cis rs4332037 0.707 rs11763813 chr7:1896690 C/T cg23422044 chr7:1970798 MAD1L1 -0.55 -6.87 -0.35 3.19e-11 Bipolar disorder; CRC cis rs1451375 0.698 rs56233242 chr7:50634053 C/A cg18232548 chr7:50535776 DDC 0.44 6.26 0.33 1.23e-9 Malaria; CRC cis rs734999 0.505 rs10797439 chr1:2540364 G/A cg18854424 chr1:2615690 NA 0.49 9.91 0.48 2.04e-20 Ulcerative colitis; CRC cis rs2742540 0.524 rs2653562 chr11:8918160 A/T cg14711859 chr11:8959438 ASCL3 0.57 10.18 0.49 2.4e-21 Hematocrit; CRC cis rs826838 1.000 rs4768328 chr12:39129315 C/T cg26384229 chr12:38710491 ALG10B -0.64 -9.67 -0.47 1.21e-19 Heart rate; CRC cis rs9894429 0.646 rs9902264 chr17:79613828 G/A cg13777783 chr17:79615861 NA -0.3 -5.73 -0.3 2.27e-8 Eye color traits; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg26771998 chr10:75490334 BMS1P4 0.46 6.94 0.36 2.04e-11 Intelligence (multi-trait analysis); CRC cis rs2795502 0.630 rs2914988 chr10:43509354 A/T cg20628663 chr10:43360327 NA 0.57 6.62 0.34 1.43e-10 Blood protein levels; CRC cis rs1448094 0.556 rs11611968 chr12:86168022 G/A cg06740227 chr12:86229804 RASSF9 0.37 5.62 0.3 4.02e-8 Major depressive disorder; CRC cis rs1150668 0.830 rs2531831 chr6:28388765 C/G cg21251018 chr6:28226885 NKAPL 0.5 8.61 0.43 3.05e-16 Pubertal anthropometrics; CRC cis rs6120849 0.754 rs6120812 chr20:33629427 T/C cg08999081 chr20:33150536 PIGU 0.44 5.73 0.3 2.23e-8 Protein C levels; CRC cis rs13191362 1.000 rs13209100 chr6:163159350 C/T cg14584255 chr6:163149320 PACRG;PARK2 0.37 6.33 0.33 7.88e-10 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs17826219 0.706 rs609472 chr17:28951427 T/C cg19761014 chr17:28927070 LRRC37B2 0.56 6.66 0.34 1.14e-10 Body mass index; CRC trans rs1005277 0.579 rs2474574 chr10:38387295 C/T cg27523141 chr10:43048294 ZNF37B 0.49 7.21 0.37 3.88e-12 Extrinsic epigenetic age acceleration; CRC cis rs72799341 1.000 rs7200879 chr16:30947572 A/G cg00531865 chr16:30841666 NA -0.5 -5.8 -0.3 1.59e-8 Diastolic blood pressure; CRC cis rs7223966 1.000 rs11079508 chr17:61750066 T/C cg23090583 chr17:61904693 PSMC5;FTSJ3 0.48 6.0 0.31 5.06e-9 Hip circumference adjusted for BMI;Body mass index; CRC cis rs9300255 0.679 rs58809476 chr12:123724880 C/T cg00376283 chr12:123451042 ABCB9 -0.48 -5.62 -0.3 4.01e-8 Neutrophil percentage of white cells; CRC cis rs6500602 0.702 rs4786493 chr16:4500122 C/T cg08645402 chr16:4508243 NA 0.6 10.98 0.52 4.03e-24 Schizophrenia; CRC cis rs9549260 0.755 rs9566553 chr13:41174231 A/G cg21288729 chr13:41239152 FOXO1 0.39 5.99 0.31 5.39e-9 Red blood cell count; CRC cis rs26868 0.766 rs27556 chr16:2249325 T/C cg07587117 chr16:2239488 CASKIN1 0.43 7.63 0.39 2.59e-13 Height; CRC cis rs7618915 0.547 rs33967311 chr3:52683864 G/T cg18404041 chr3:52824283 ITIH1 -0.43 -8.73 -0.43 1.34e-16 Bipolar disorder; CRC cis rs7224737 1.000 rs7214921 chr17:40294025 T/C cg20291162 chr17:40259547 DHX58 -0.55 -8.01 -0.4 2.06e-14 Fibrinogen levels; CRC cis rs4566357 0.615 rs2272202 chr2:227914625 C/T cg11843606 chr2:227700838 RHBDD1 0.45 7.03 0.36 1.17e-11 Coronary artery disease; CRC cis rs6662572 0.737 rs2067635 chr1:46537946 T/G cg03123370 chr1:45965343 CCDC163P;MMACHC 0.48 6.22 0.32 1.54e-9 Blood protein levels; CRC cis rs2066819 0.892 rs2066807 chr12:56740682 C/G cg26714650 chr12:56694279 CS -1.41 -11.34 -0.53 2.29e-25 Psoriasis vulgaris; CRC trans rs10802346 0.545 rs10924568 chr1:246385482 C/A cg22732515 chr19:44031385 ETHE1 0.7 10.59 0.5 9.61e-23 Fractional exhaled nitric oxide (childhood); CRC cis rs727505 0.866 rs67724276 chr7:124719719 G/A cg23710748 chr7:124431027 NA -0.72 -12.17 -0.56 2.14e-28 Lewy body disease; CRC cis rs514406 0.584 rs7524702 chr1:53197830 G/A cg25767906 chr1:53392781 SCP2 0.42 6.6 0.34 1.6e-10 Monocyte count; CRC cis rs447735 0.587 rs11640702 chr16:89729169 A/G cg03605463 chr16:89740564 NA -0.46 -7.44 -0.38 8.66e-13 Hemoglobin concentration; CRC cis rs10744422 0.858 rs2292136 chr12:123339344 A/G cg25930673 chr12:123319894 HIP1R -0.61 -6.42 -0.33 4.65e-10 Schizophrenia; CRC trans rs1997103 1.000 rs11238364 chr7:55407632 G/T cg20935933 chr6:143382018 AIG1 0.51 6.65 0.34 1.25e-10 QRS interval (sulfonylurea treatment interaction); CRC cis rs7703744 0.681 rs73239280 chr5:118695579 G/A cg17471836 chr5:118691007 TNFAIP8 0.43 5.97 0.31 6.09e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs9910055 0.529 rs615070 chr17:42176591 A/G cg13607699 chr17:42295918 UBTF 0.47 6.27 0.33 1.13e-9 Total body bone mineral density; CRC cis rs11212617 1.000 rs11212619 chr11:108289167 A/G cg14761454 chr11:108092087 ATM;NPAT 0.41 6.12 0.32 2.61e-9 Response to metformin in type 2 diabetes (glycemic); CRC cis rs477692 0.673 rs579325 chr10:131363688 C/T cg05714579 chr10:131428358 MGMT 0.46 6.56 0.34 2.14e-10 Response to temozolomide; CRC trans rs7395662 0.591 rs4882093 chr11:48530820 G/A cg03929089 chr4:120376271 NA -0.46 -6.52 -0.34 2.69e-10 HDL cholesterol; CRC cis rs898097 0.578 rs6502021 chr17:80907728 T/C cg15664640 chr17:80829946 TBCD 0.47 7.91 0.4 4.07e-14 Breast cancer; CRC cis rs2635047 0.967 rs2571016 chr18:44639175 C/G cg19077165 chr18:44547161 KATNAL2 0.5 8.13 0.41 9.13e-15 Educational attainment; CRC cis rs2949837 0.581 rs2965072 chr7:45980751 G/T cg04796162 chr7:45961102 IGFBP3 0.41 7.06 0.36 9.63e-12 Sitting height ratio; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg13968099 chr5:162864768 CCNG1 0.36 6.03 0.32 4.52e-9 Liver disease severity in Alagille syndrome; CRC cis rs9549367 0.826 rs2287249 chr13:113889355 A/G cg00898013 chr13:113819073 PROZ -0.46 -6.82 -0.35 4.32e-11 Platelet distribution width; CRC cis rs9487051 0.676 rs7775206 chr6:109597222 A/G cg01475377 chr6:109611718 NA -0.39 -6.89 -0.36 2.77e-11 Reticulocyte fraction of red cells; CRC cis rs12148488 0.816 rs11854975 chr15:75363876 C/T cg09165964 chr15:75287851 SCAMP5 0.57 9.16 0.45 5.56e-18 Caffeine consumption; CRC cis rs853679 1.000 rs13200462 chr6:28218199 A/C cg03623178 chr6:28175578 NA 0.73 6.97 0.36 1.75e-11 Depression; CRC cis rs1008375 1.000 rs6811887 chr4:17640858 C/T cg04450456 chr4:17643702 FAM184B 0.4 6.51 0.34 2.81e-10 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs2949837 0.581 rs2949838 chr7:45993924 T/C cg21268650 chr7:45961089 IGFBP3 0.38 6.59 0.34 1.78e-10 Sitting height ratio; CRC cis rs775227 1.000 rs13093350 chr3:112993063 A/G cg18753928 chr3:113234510 CCDC52 0.44 5.61 0.3 4.32e-8 Dental caries; CRC cis rs7666738 0.830 rs6840766 chr4:99016260 C/G cg05340658 chr4:99064831 C4orf37 0.62 9.64 0.47 1.5700000000000001e-19 Colonoscopy-negative controls vs population controls; CRC cis rs2463822 1.000 rs2246920 chr11:62104937 T/G cg06239285 chr11:62104954 ASRGL1 0.97 11.5 0.54 6.08e-26 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs11098499 0.754 rs7672372 chr4:120248406 A/G cg24375607 chr4:120327624 NA 0.48 7.67 0.39 1.92e-13 Corneal astigmatism; CRC cis rs897984 0.644 rs73524556 chr16:30823162 G/A cg00531865 chr16:30841666 NA -0.51 -7.52 -0.38 5.22e-13 Dementia with Lewy bodies; CRC cis rs10504229 0.728 rs72650852 chr8:58150463 G/A cg21724239 chr8:58056113 NA 0.62 7.9 0.4 4.15e-14 Developmental language disorder (linguistic errors); CRC cis rs9303401 0.659 rs62081316 chr17:56781499 C/T cg10487724 chr17:56770010 TEX14;RAD51C 0.79 10.0 0.48 1.01e-20 Cognitive test performance; CRC cis rs11098499 0.690 rs34818745 chr4:120257055 T/C cg24375607 chr4:120327624 NA 0.46 6.59 0.34 1.71e-10 Corneal astigmatism; CRC cis rs17253792 0.822 rs78323463 chr14:56045451 T/G cg01858014 chr14:56050164 KTN1 -0.88 -7.09 -0.36 8.36e-12 Putamen volume; CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg26539663 chr17:7590939 WRAP53;TP53 0.38 6.12 0.32 2.72e-9 Obesity-related traits; CRC cis rs2739330 0.760 rs1007888 chr22:24241101 C/T cg16132339 chr22:24313637 DDTL;DDT 0.56 8.75 0.43 1.1e-16 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs13108904 0.870 rs11721789 chr4:1254414 C/A cg02018176 chr4:1364513 KIAA1530 0.45 7.56 0.38 4.03e-13 Obesity-related traits; CRC cis rs13108904 0.870 rs11721789 chr4:1254414 C/A cg19318889 chr4:1322082 MAEA 0.41 5.95 0.31 6.97e-9 Obesity-related traits; CRC cis rs561341 1.000 rs7214017 chr17:30332220 T/C cg00745463 chr17:30367425 LRRC37B -0.74 -8.78 -0.44 8.89e-17 Hip circumference adjusted for BMI; CRC cis rs2760061 0.505 rs708109 chr1:228190657 C/T cg02753203 chr1:228287806 NA 0.87 12.74 0.57 1.71e-30 Diastolic blood pressure; CRC cis rs11190604 0.943 rs7085261 chr10:102209811 G/A cg07080220 chr10:102295463 HIF1AN 0.47 5.79 0.3 1.63e-8 Palmitoleic acid (16:1n-7) levels; CRC cis rs28386778 0.897 rs9913323 chr17:61851485 C/A cg23090583 chr17:61904693 PSMC5;FTSJ3 1.04 20.53 0.75 6.95e-61 Prudent dietary pattern; CRC cis rs12368653 0.651 rs2277326 chr12:58202419 A/C cg00677455 chr12:58241039 CTDSP2 0.49 6.62 0.34 1.48e-10 Multiple sclerosis; CRC cis rs801193 1.000 rs7785213 chr7:66138978 A/C cg18876405 chr7:65276391 NA -0.61 -10.81 -0.51 1.58e-23 Aortic root size; CRC cis rs853679 0.517 rs4711165 chr6:28115184 T/G cg12963246 chr6:28129442 ZNF389 0.49 5.7 0.3 2.71e-8 Depression; CRC cis rs2839186 0.900 rs56840278 chr21:47708933 T/G cg02776659 chr21:47717406 C21orf57 -0.34 -5.62 -0.3 4.13e-8 Testicular germ cell tumor; CRC cis rs79387448 0.638 rs76255660 chr2:103091028 T/C cg09003973 chr2:102972529 NA 0.84 8.53 0.43 5.41e-16 Gut microbiota (bacterial taxa); CRC cis rs736408 0.527 rs2577831 chr3:52628056 C/A cg10802521 chr3:52805072 NEK4 -0.45 -7.02 -0.36 1.26e-11 Bipolar disorder; CRC cis rs6694672 1.000 rs6695300 chr1:197098143 G/C cg13682187 chr1:196946512 CFHR5 0.54 8.03 0.4 1.73e-14 Asthma; CRC cis rs7465272 0.957 rs11994668 chr8:143687392 G/T cg19438565 chr8:143695827 ARC -0.48 -6.78 -0.35 5.68e-11 Bipolar disorder and schizophrenia; CRC cis rs1552244 0.572 rs3894321 chr3:10168892 A/C cg08888203 chr3:10149979 C3orf24 0.72 8.86 0.44 5.2e-17 Alzheimer's disease; CRC cis rs6502050 0.835 rs8081949 chr17:80117490 G/A cg19223190 chr17:80058835 NA 0.39 6.25 0.33 1.27e-9 Life satisfaction; CRC cis rs9527 0.590 rs7898770 chr10:104756636 A/G cg04362960 chr10:104952993 NT5C2 -0.58 -8.26 -0.41 3.57e-15 Arsenic metabolism; CRC cis rs6783573 0.535 rs12637699 chr3:46628443 C/T cg21489266 chr3:46619131 LRRC2;TDGF1 -0.4 -5.91 -0.31 8.39e-9 Cerebrospinal fluid biomarker levels; CRC cis rs3020333 0.653 rs851982 chr6:152024985 T/C cg22157087 chr6:152012887 ESR1 0.49 7.21 0.37 3.93e-12 Total body bone mineral density; CRC cis rs950776 0.518 rs2869055 chr15:78822388 G/C cg06917634 chr15:78832804 PSMA4 -0.6 -9.58 -0.47 2.54e-19 Sudden cardiac arrest; CRC cis rs4713118 0.869 rs7776351 chr6:27726731 A/G cg08798685 chr6:27730294 NA 0.44 6.48 0.34 3.28e-10 Parkinson's disease; CRC cis rs7712401 0.686 rs246305 chr5:122199606 A/T cg18764291 chr5:122110994 SNX2 0.35 5.61 0.3 4.3e-8 Mean platelet volume; CRC cis rs7666738 0.962 rs11932892 chr4:99072967 C/T cg17366294 chr4:99064904 C4orf37 0.43 6.8 0.35 5.08e-11 Colonoscopy-negative controls vs population controls; CRC cis rs1448094 0.512 rs10779216 chr12:86240315 A/G cg19622623 chr12:86230825 RASSF9 0.41 6.62 0.34 1.49e-10 Major depressive disorder; CRC cis rs9911578 0.967 rs4932693 chr17:57110327 T/C cg12560992 chr17:57184187 TRIM37 -0.95 -17.85 -0.7 2.63e-50 Intelligence (multi-trait analysis); CRC trans rs8064024 0.513 rs1049208 chr16:4934549 G/A cg19252218 chr17:41477271 ARL4D -0.42 -6.21 -0.32 1.57e-9 Cancer; CRC cis rs2404602 0.735 rs4886798 chr15:76673226 A/G cg23625390 chr15:77176239 SCAPER 0.82 13.05 0.58 1.18e-31 Blood metabolite levels; CRC cis rs17376456 0.877 rs10476598 chr5:93367281 C/T cg25358565 chr5:93447407 FAM172A -0.99 -10.94 -0.52 5.9e-24 Diabetic retinopathy; CRC cis rs599083 0.530 rs546803 chr11:68186392 C/T cg16797656 chr11:68205561 LRP5 -0.42 -6.65 -0.34 1.24e-10 Bone mineral density (spine); CRC cis rs972578 0.905 rs56026835 chr22:43363122 A/C cg01576275 chr22:43409880 NA -0.45 -7.27 -0.37 2.62e-12 Mean platelet volume; CRC cis rs2180341 0.566 rs982306 chr6:127777039 T/C cg24812749 chr6:127587940 RNF146 0.57 7.5 0.38 6.15e-13 Breast cancer; CRC cis rs4689592 0.513 rs4689586 chr4:7067413 A/G cg06697600 chr4:7070879 GRPEL1 -0.5 -7.36 -0.38 1.48e-12 Monocyte percentage of white cells; CRC cis rs6570726 0.935 rs414222 chr6:145850482 C/T cg23711669 chr6:146136114 FBXO30 0.68 12.3 0.56 7.07e-29 Lobe attachment (rater-scored or self-reported); CRC trans rs12599106 0.560 rs34151874 chr16:34989694 G/A cg18110333 chr6:292329 DUSP22 -0.7 -10.31 -0.49 8.61e-22 Menopause (age at onset); CRC cis rs672059 1.000 rs549844 chr1:183158143 A/G ch.1.3577855R chr1:183094577 LAMC1 -0.52 -7.58 -0.39 3.59e-13 Hypertriglyceridemia; CRC cis rs11792861 0.926 rs72607172 chr9:111876523 A/G cg05043794 chr9:111880884 C9orf5 -0.36 -6.6 -0.34 1.66e-10 Menarche (age at onset); CRC cis rs8060686 0.858 rs7198357 chr16:67884619 A/G cg26727032 chr16:67993705 SLC12A4 0.67 10.35 0.5 6.47e-22 HDL cholesterol;Metabolic syndrome; CRC cis rs9325144 0.555 rs6582607 chr12:38717678 T/C cg26384229 chr12:38710491 ALG10B -0.58 -8.42 -0.42 1.15e-15 Morning vs. evening chronotype; CRC cis rs60871478 0.541 rs56964970 chr7:910791 G/C cg05535760 chr7:792225 HEATR2 -0.89 -10.02 -0.48 8.61e-21 Cerebrospinal P-tau181p levels; CRC cis rs11622475 1.000 rs2236247 chr14:104378087 C/T cg20488157 chr14:104394430 TDRD9 0.54 7.54 0.38 4.52e-13 Bipolar disorder; CRC cis rs769267 0.930 rs9917108 chr19:19572785 A/G cg03709012 chr19:19516395 GATAD2A 0.72 11.24 0.53 4.97e-25 Tonsillectomy; CRC cis rs10256972 0.552 rs6978842 chr7:1204599 A/C cg23708337 chr7:1209742 NA 0.5 7.73 0.39 1.32e-13 Longevity;Endometriosis; CRC cis rs9914988 0.943 rs9890377 chr17:27111111 A/G cg07195577 chr17:27052828 TLCD1 0.42 6.02 0.32 4.64e-9 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs7607369 0.536 rs4646535 chr2:219664663 C/T cg02176678 chr2:219576539 TTLL4 -0.41 -6.63 -0.34 1.39e-10 Red blood cell count;Amyotrophic lateral sclerosis; CRC cis rs3820068 0.581 rs6669417 chr1:15922371 G/T cg17385448 chr1:15911702 AGMAT 0.29 5.86 0.31 1.14e-8 Systolic blood pressure; CRC cis rs7082209 0.540 rs800310 chr10:44815048 A/T cg09554077 chr10:44749378 NA -0.4 -6.11 -0.32 2.83e-9 Resistance to Mycobacterium tuberculosis in HIV-positive individuals measured by a negative tuberculin skin test (continuous); CRC cis rs9818758 0.607 rs34343820 chr3:49309534 C/G cg00383909 chr3:49044727 WDR6 1.1 10.48 0.5 2.33e-22 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; CRC cis rs10504229 0.683 rs11787247 chr8:58131528 G/T cg02290350 chr8:58132656 NA -0.58 -8.16 -0.41 7.29e-15 Developmental language disorder (linguistic errors); CRC trans rs12599106 0.754 rs11640596 chr16:34347277 T/C cg05064044 chr6:292385 DUSP22 -0.59 -8.1 -0.41 1.06e-14 Menopause (age at onset); CRC cis rs11212617 0.967 rs2356802 chr11:108282169 A/G cg12106634 chr11:108092400 ATM;NPAT 0.44 6.63 0.34 1.42e-10 Response to metformin in type 2 diabetes (glycemic); CRC cis rs6988636 1.000 rs16898095 chr8:124193523 T/C cg27053337 chr8:124217698 FAM83A 0.42 6.36 0.33 6.62e-10 Urinary uromodulin levels; CRC cis rs1046896 0.553 rs3744160 chr17:80828303 G/A cg17346650 chr17:80929145 B3GNTL1 0.49 7.36 0.38 1.48e-12 Glycated hemoglobin levels; CRC cis rs9527 0.590 rs10883829 chr10:104840635 T/C cg04362960 chr10:104952993 NT5C2 0.58 8.11 0.41 1.04e-14 Arsenic metabolism; CRC cis rs6502050 0.835 rs9674648 chr17:80096756 A/G cg22110888 chr17:80059540 CCDC57 0.41 6.7 0.35 8.86e-11 Life satisfaction; CRC cis rs9435341 0.965 rs1730862 chr1:107614003 G/A cg11070056 chr1:107600091 PRMT6 -0.4 -5.74 -0.3 2.19e-8 Facial morphology (factor 21, depth of nasal alae); CRC trans rs10504229 0.906 rs56138544 chr8:58184558 A/C cg04077850 chr5:125800366 GRAMD3 0.37 6.27 0.33 1.15e-9 Developmental language disorder (linguistic errors); CRC trans rs7395662 0.500 rs7947055 chr11:48977086 C/T cg21153622 chr11:89784906 NA 0.45 7.1 0.36 7.58e-12 HDL cholesterol; CRC cis rs13191362 0.507 rs2849525 chr6:163126652 A/C cg21926612 chr6:163149169 PACRG;PARK2 -0.63 -9.95 -0.48 1.49e-20 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs924607 1.000 rs1697978 chr5:642829 A/G cg04476341 chr5:669733 TPPP 0.43 6.89 0.36 2.82e-11 Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia; CRC cis rs514406 0.929 rs557920 chr1:53338757 C/A cg24675658 chr1:53192096 ZYG11B -0.58 -8.41 -0.42 1.29e-15 Monocyte count; CRC cis rs1552244 0.810 rs35711405 chr3:10116939 C/T cg18598329 chr3:10140678 FANCD2;C3orf24 -0.87 -11.82 -0.55 4.24e-27 Alzheimer's disease; CRC cis rs4728302 0.871 rs10259686 chr7:133633152 A/G cg03336402 chr7:133662267 EXOC4 0.43 6.35 0.33 6.96e-10 Intelligence;Intelligence (multi-trait analysis); CRC cis rs7086627 0.515 rs7077373 chr10:82211615 C/T cg00277334 chr10:82204260 NA -0.84 -16.95 -0.68 9.58e-47 Post bronchodilator FEV1; CRC cis rs7613875 0.521 rs4688754 chr3:50074641 G/T cg24308560 chr3:49941425 MST1R 0.42 6.52 0.34 2.66e-10 Body mass index; CRC cis rs4423214 0.840 rs1792227 chr11:71177412 A/G cg13043300 chr11:71146211 DHCR7 -0.44 -5.91 -0.31 8.58e-9 Vitamin D levels; CRC cis rs8067545 0.611 rs2526466 chr17:20165251 C/T cg13482628 chr17:19912719 NA -0.48 -7.4 -0.38 1.17e-12 Schizophrenia; CRC trans rs2243480 1.000 rs2707831 chr7:66062511 G/A cg10756647 chr7:56101905 PSPH 0.75 7.84 0.4 6.2e-14 Diabetic kidney disease; CRC cis rs11577318 0.853 rs7537477 chr1:26618829 C/T cg00852783 chr1:26633632 UBXN11 0.5 7.14 0.37 5.95e-12 Granulocyte percentage of myeloid white cells; CRC cis rs9942416 0.660 rs67054144 chr5:74991443 G/A cg00601450 chr5:74908170 NA 0.41 5.76 0.3 1.95e-8 Age-related disease endophenotypes; CRC cis rs2635047 1.000 rs2684826 chr18:44679147 A/G cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.41 6.8 0.35 5.08e-11 Educational attainment; CRC cis rs12541635 0.677 rs10808408 chr8:107005034 C/T cg10147462 chr8:107024639 NA 0.58 10.17 0.49 2.54e-21 Age of smoking initiation; CRC cis rs6121246 0.529 rs6060291 chr20:30198043 T/G cg18721089 chr20:30220636 NA -0.53 -8.01 -0.4 2.02e-14 Mean corpuscular hemoglobin; CRC cis rs2282802 0.685 rs13170475 chr5:139671062 C/T cg26211634 chr5:139558579 C5orf32 0.44 7.61 0.39 2.83e-13 Intelligence (multi-trait analysis); CRC cis rs7122539 0.646 rs627330 chr11:66602099 C/T cg24851651 chr11:66362959 CCS 0.52 9.95 0.48 1.42e-20 HIV-1 susceptibility; CRC cis rs763121 0.853 rs3788545 chr22:39065172 A/G cg06544989 chr22:39130855 UNC84B 0.46 7.06 0.36 9.69e-12 Menopause (age at onset); CRC cis rs10540 1.000 rs12418639 chr11:473300 A/C cg19913688 chr11:428466 ANO9 0.71 7.28 0.37 2.5e-12 Body mass index; CRC cis rs12580194 0.593 rs11171416 chr12:55731490 A/G cg23425280 chr12:56401806 NA 0.47 5.93 0.31 7.65e-9 Cancer; CRC trans rs3780486 0.846 rs7865745 chr9:33140976 A/G cg04842962 chr6:43655489 MRPS18A -1.18 -25.84 -0.82 3.4e-81 IgG glycosylation; CRC cis rs873946 0.529 rs12258248 chr10:134573767 A/G cg06453172 chr10:134556979 INPP5A -0.61 -8.09 -0.41 1.2e-14 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CRC trans rs2055729 0.645 rs7828229 chr8:9742841 C/T cg08975724 chr8:8085496 FLJ10661 -0.46 -6.01 -0.31 5.02e-9 Multiple myeloma (hyperdiploidy); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg01096752 chr19:49468454 FTL 0.37 5.96 0.31 6.5e-9 Liver disease severity in Alagille syndrome; CRC cis rs2439831 0.571 rs2470121 chr15:43937618 G/C cg02155558 chr15:43621948 ADAL;LCMT2 0.67 7.57 0.38 3.88e-13 Lung cancer in ever smokers; CRC cis rs896854 0.967 rs10956933 chr8:95967688 C/G cg23172400 chr8:95962367 TP53INP1 -0.49 -8.25 -0.41 3.82e-15 Type 2 diabetes; CRC cis rs727505 1.000 rs10281582 chr7:124423688 A/G cg23710748 chr7:124431027 NA -0.66 -11.79 -0.54 5.4e-27 Lewy body disease; CRC cis rs10927875 0.541 rs1048245 chr1:16341354 T/G cg24140574 chr1:16342155 HSPB7 0.46 6.53 0.34 2.46e-10 Dilated cardiomyopathy; CRC cis rs12477438 0.765 rs28648058 chr2:99696417 G/A cg14399236 chr2:99771627 LIPT1;TSGA10 -0.6 -8.18 -0.41 6.47e-15 Chronic sinus infection; CRC cis rs2811415 0.597 rs13094149 chr3:127795569 C/T cg13719885 chr3:127795394 NA -0.39 -5.86 -0.31 1.12e-8 Lung function (FEV1/FVC); CRC cis rs9388451 0.626 rs3799712 chr6:126075103 A/G cg05901451 chr6:126070800 HEY2 -0.54 -9.01 -0.45 1.66e-17 Brugada syndrome; CRC cis rs7914558 0.752 rs7896519 chr10:104866863 C/T cg08772003 chr10:104629869 AS3MT -0.34 -5.76 -0.3 1.95e-8 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs2949837 0.581 rs2965068 chr7:45974375 T/C cg04727332 chr7:45960243 IGFBP3 0.36 5.85 0.31 1.18e-8 Sitting height ratio; CRC cis rs10504229 0.683 rs11786043 chr8:58133174 T/C cg02290350 chr8:58132656 NA -0.58 -8.16 -0.41 7.29e-15 Developmental language disorder (linguistic errors); CRC cis rs6732160 0.588 rs28626211 chr2:73378522 G/A cg01422370 chr2:73384389 NA 0.37 5.82 0.31 1.39e-8 Intelligence (multi-trait analysis); CRC cis rs734999 0.566 rs4648563 chr1:2536002 C/G cg20673091 chr1:2541236 MMEL1 0.37 6.02 0.31 4.78e-9 Ulcerative colitis; CRC trans rs1814175 0.791 rs11040513 chr11:49778153 G/C cg15704280 chr7:45808275 SEPT13 -1.01 -20.58 -0.75 4.39e-61 Height; CRC cis rs12545109 0.800 rs2576592 chr8:57419357 A/C cg09654669 chr8:57350985 NA -0.45 -7.22 -0.37 3.74e-12 Obesity-related traits; CRC cis rs13191362 0.935 rs35100164 chr6:162963003 T/C cg06582575 chr6:163149167 PACRG;PARK2 0.81 10.14 0.49 3.29e-21 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs11098699 0.784 rs11098701 chr4:124216461 C/G cg09941581 chr4:124220074 SPATA5 0.42 6.28 0.33 1.05e-9 Mosquito bite size; CRC cis rs6502050 0.835 rs4247357 chr17:80166989 G/T cg19223190 chr17:80058835 NA 0.42 6.89 0.35 2.92e-11 Life satisfaction; CRC cis rs372883 0.648 rs1153291 chr21:30689070 G/T cg24692254 chr21:30365293 RNF160 -0.59 -8.76 -0.43 1.09e-16 Pancreatic cancer; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg25229157 chr1:51426110 FAF1 0.43 6.03 0.32 4.45e-9 Response to antipsychotic treatment; CRC cis rs72799341 1.000 rs72799341 chr16:30936743 G/A cg02466173 chr16:30829666 NA -0.74 -9.15 -0.45 6.04e-18 Diastolic blood pressure; CRC cis rs2742417 0.603 rs2673032 chr3:45756927 C/T cg04837898 chr3:45731254 SACM1L -0.49 -7.9 -0.4 4.31e-14 Response to anti-depressant treatment in major depressive disorder; CRC cis rs4731207 0.596 rs10081226 chr7:124575529 C/A cg23710748 chr7:124431027 NA -0.39 -6.19 -0.32 1.8e-9 Cutaneous malignant melanoma; CRC cis rs73206853 0.660 rs12313068 chr12:110597304 C/T cg12870014 chr12:110450643 ANKRD13A 0.7 9.75 0.47 6.84e-20 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC cis rs6570726 0.967 rs450973 chr6:145863065 C/A cg05347473 chr6:146136440 FBXO30 0.37 5.83 0.31 1.34e-8 Lobe attachment (rater-scored or self-reported); CRC cis rs4862750 0.914 rs6814259 chr4:187872337 T/C cg03452623 chr4:187889614 NA -0.89 -19.74 -0.74 8.98e-58 Lobe attachment (rater-scored or self-reported); CRC cis rs1976403 0.633 rs1780324 chr1:21821757 A/G cg02390115 chr1:21767211 NBPF3 0.53 7.84 0.4 6.46e-14 Liver enzyme levels (alkaline phosphatase); CRC trans rs11165623 0.792 rs1931180 chr1:96914049 C/T cg10631902 chr5:14652156 NA -0.51 -9.69 -0.47 1.04e-19 Hip circumference;Waist circumference; CRC cis rs17756712 0.725 rs57440245 chr6:616855 G/C cg16786516 chr6:604617 EXOC2 0.46 5.66 0.3 3.35e-8 Vertical cup-disc ratio; CRC cis rs13118159 0.836 rs12647145 chr4:1338618 C/A cg02018176 chr4:1364513 KIAA1530 0.39 6.62 0.34 1.46e-10 Longevity; CRC cis rs4713118 0.539 rs200951 chr6:27835930 A/G cg20615401 chr6:28092323 ZSCAN16 0.43 5.62 0.3 4.13e-8 Parkinson's disease; CRC trans rs4332037 0.539 rs55773130 chr7:2070554 T/C cg11693508 chr17:37793320 STARD3 0.61 7.18 0.37 4.7e-12 Bipolar disorder; CRC cis rs172166 0.637 rs1225597 chr6:28162087 C/T cg15845792 chr6:28175446 NA 0.86 13.56 0.6 1.46e-33 Cardiac Troponin-T levels; CRC cis rs561341 0.941 rs72825746 chr17:30364610 G/A cg00745463 chr17:30367425 LRRC37B -0.88 -9.68 -0.47 1.15e-19 Hip circumference adjusted for BMI; CRC cis rs6066835 0.867 rs73118616 chr20:47364704 G/C cg18078177 chr20:47281410 PREX1 0.62 5.72 0.3 2.35e-8 Multiple myeloma; CRC cis rs561341 0.714 rs473535 chr17:30312365 A/G cg23018236 chr17:30244563 NA -0.66 -7.82 -0.4 7.05e-14 Hip circumference adjusted for BMI; CRC cis rs17818399 0.653 rs34050156 chr2:46777646 A/G cg06386533 chr2:46925753 SOCS5 0.48 6.0 0.31 5.21e-9 Height; CRC cis rs2777491 1.000 rs1757455 chr15:41761332 G/T cg18705301 chr15:41695430 NDUFAF1 -0.75 -13.02 -0.58 1.57e-31 Ulcerative colitis; CRC trans rs9858542 0.903 rs11917431 chr3:49644012 C/T cg21665057 chr3:196295764 WDR53;FBXO45 -0.69 -8.97 -0.44 2.24e-17 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs7618915 0.501 rs1866268 chr3:52719398 C/A cg08222913 chr3:52553049 STAB1 -0.34 -6.39 -0.33 5.63e-10 Bipolar disorder; CRC cis rs9549328 0.616 rs35086993 chr13:113617305 G/A cg25790453 chr13:113633590 MCF2L 0.44 7.65 0.39 2.22e-13 Systolic blood pressure; CRC cis rs4969178 0.965 rs56658017 chr17:76396164 G/A cg05887092 chr17:76393375 PGS1 0.55 10.04 0.48 7.22e-21 HDL cholesterol levels; CRC trans rs12200782 0.649 rs9467746 chr6:26387405 A/G cg25800765 chr12:85673347 ALX1 0.26 5.96 0.31 6.54e-9 Small cell lung carcinoma; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg23359706 chr19:11491839 EPOR 0.45 6.37 0.33 6.34e-10 Response to antipsychotic treatment; CRC cis rs4700695 0.697 rs251319 chr5:65239468 A/G cg21114390 chr5:65439923 SFRS12 0.5 6.18 0.32 1.95e-9 Facial morphology (factor 19); CRC cis rs4713118 0.869 rs6902689 chr6:27709441 C/T cg03623178 chr6:28175578 NA 0.68 9.43 0.46 7.56e-19 Parkinson's disease; CRC cis rs6479527 0.710 rs2226117 chr9:96750661 G/A cg14459158 chr9:96720562 NA 0.41 7.52 0.38 5.11e-13 Esophageal adenocarcinoma; CRC cis rs853679 0.517 rs9393887 chr6:28059020 G/A cg02683197 chr6:28174875 NA 0.82 10.11 0.49 4.09e-21 Depression; CRC cis rs7605378 1.000 rs2346662 chr2:200679158 C/T cg23649088 chr2:200775458 C2orf69 0.58 8.23 0.41 4.38e-15 Osteoporosis; CRC cis rs10504229 0.728 rs72650860 chr8:58153111 A/G cg11062466 chr8:58055876 NA 0.45 6.11 0.32 2.74e-9 Developmental language disorder (linguistic errors); CRC cis rs992157 0.835 rs2271543 chr2:219142491 C/T cg13835894 chr2:219148914 PNKD;TMBIM1 -0.35 -6.75 -0.35 6.68e-11 Colorectal cancer; CRC cis rs2257205 0.667 rs7342841 chr17:56916156 G/A cg25885038 chr17:56607967 SEPT4 -0.53 -5.82 -0.31 1.43e-8 Pancreatic cancer; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg01016553 chr1:51810627 TTC39A -0.39 -6.06 -0.32 3.75e-9 Myopia (pathological); CRC cis rs9341808 0.667 rs2490241 chr6:80846342 T/C cg08355045 chr6:80787529 NA 0.34 5.81 0.31 1.47e-8 Sitting height ratio; CRC cis rs875971 0.862 rs7796162 chr7:65745758 T/C cg12463550 chr7:65579703 CRCP -0.49 -6.69 -0.35 9.77e-11 Aortic root size; CRC cis rs13064411 0.696 rs13325046 chr3:113104444 C/T cg18753928 chr3:113234510 CCDC52 -0.6 -7.93 -0.4 3.43e-14 Response to simvastatin treatment (PCSK9 protein level change); CRC cis rs4481887 0.893 rs7538645 chr1:248478137 C/T cg00666640 chr1:248458726 OR2T12 0.49 8.27 0.41 3.45e-15 Common traits (Other); CRC cis rs12541635 0.653 rs7014265 chr8:107026412 G/A cg10147462 chr8:107024639 NA 0.59 9.85 0.48 3.11e-20 Age of smoking initiation; CRC cis rs8072100 0.967 rs8078880 chr17:45676526 G/C cg25173405 chr17:45401733 C17orf57 0.43 6.59 0.34 1.74e-10 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs10464366 0.746 rs34792397 chr7:39146331 G/A cg18850127 chr7:39170497 POU6F2 0.49 6.51 0.34 2.89e-10 IgG glycosylation; CRC cis rs6960043 0.738 rs4721400 chr7:15059906 G/A cg19272540 chr7:15055459 NA 0.25 6.8 0.35 4.84e-11 Type 2 diabetes; CRC cis rs7493 0.755 rs17166861 chr7:95020602 G/C cg17330251 chr7:94953956 PON1 -0.54 -6.78 -0.35 5.59e-11 Yu-Zhi constitution type in type 2 diabetes; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg08722104 chr11:47448306 PSMC3 0.52 7.3 0.37 2.12e-12 Response to antipsychotic treatment; CRC trans rs3733585 0.673 rs4467564 chr4:9953472 G/T cg26043149 chr18:55253948 FECH -0.5 -7.71 -0.39 1.51e-13 Cleft plate (environmental tobacco smoke interaction); CRC cis rs73200209 0.625 rs11611787 chr12:116644886 G/T cg01776926 chr12:116560359 MED13L -0.61 -7.08 -0.36 8.97e-12 Total body bone mineral density; CRC cis rs1707322 0.686 rs11211179 chr1:46228082 A/C cg06784218 chr1:46089804 CCDC17 0.56 10.29 0.49 1.01e-21 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs1799949 0.965 rs34633610 chr17:41419385 A/G cg25072359 chr17:41440525 NA 0.45 6.61 0.34 1.53e-10 Menopause (age at onset); CRC cis rs736801 0.808 rs72797306 chr5:131800750 G/C cg00255919 chr5:131827918 IRF1 -0.37 -6.29 -0.33 9.98e-10 Breast cancer;Mosquito bite size; CRC cis rs910187 0.678 rs1046661 chr20:45817149 G/A cg27589058 chr20:45804311 EYA2 -0.4 -7.66 -0.39 2.09e-13 Migraine; CRC cis rs2404602 1.000 rs12594541 chr15:76834368 G/A cg03037974 chr15:76606532 NA 0.57 9.63 0.47 1.67e-19 Blood metabolite levels; CRC cis rs2075371 0.673 rs35290398 chr7:134011773 C/T cg02659138 chr7:134003124 SLC35B4 0.41 6.71 0.35 8.55e-11 Mean platelet volume; CRC cis rs939584 1.000 rs35796073 chr2:636819 C/A cg03610516 chr2:642275 NA -0.42 -5.7 -0.3 2.72e-8 Body mass index; CRC cis rs1552244 1.000 rs58275763 chr3:10143274 C/T cg18598329 chr3:10140678 FANCD2;C3orf24 -0.88 -11.98 -0.55 1.09e-27 Alzheimer's disease; CRC cis rs4664293 0.867 rs35196716 chr2:160589777 T/G cg08347373 chr2:160653686 CD302 -0.47 -7.43 -0.38 9.32e-13 Monocyte percentage of white cells; CRC cis rs9814567 1.000 rs1498718 chr3:134205920 A/G cg06109529 chr3:134205091 CEP63;ANAPC13 -0.82 -12.25 -0.56 1.09e-28 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs826838 0.935 rs1486357 chr12:39073675 A/G cg13010199 chr12:38710504 ALG10B 0.45 5.89 0.31 9.73e-9 Heart rate; CRC trans rs3780486 0.846 rs7864705 chr9:33140352 A/C cg20290983 chr6:43655470 MRPS18A 1.18 27.23 0.83 2.73e-86 IgG glycosylation; CRC trans rs1814175 0.645 rs7395438 chr11:49877379 G/T cg21153622 chr11:89784906 NA -0.39 -6.17 -0.32 2.04e-9 Height; CRC cis rs7605827 0.930 rs7590458 chr2:15601574 A/G cg19274914 chr2:15703543 NA -0.37 -5.69 -0.3 2.85e-8 Educational attainment (years of education); CRC cis rs10504229 0.683 rs17802743 chr8:58105897 C/T cg22535103 chr8:58192502 C8orf71 -0.72 -7.85 -0.4 6e-14 Developmental language disorder (linguistic errors); CRC cis rs4680 1.000 rs4680 chr22:19951271 C/T cg06346307 chr22:19949965 COMT 0.25 6.36 0.33 6.56e-10 Blood metabolite levels; CRC cis rs3862030 0.503 rs6584505 chr10:104254412 C/A cg11453585 chr10:104263688 ACTR1A;SUFU 0.9 16.72 0.68 7.16e-46 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for body mass index; CRC cis rs10992471 0.756 rs1121979 chr9:95140218 G/A cg14631576 chr9:95140430 CENPP -0.4 -7.44 -0.38 8.78e-13 Visceral adipose tissue/subcutaneous adipose tissue ratio; CRC cis rs4862750 0.914 rs1991255 chr4:187875340 G/A cg10295955 chr4:187884368 NA -1.0 -23.15 -0.79 4.87e-71 Lobe attachment (rater-scored or self-reported); CRC trans rs9858542 0.953 rs7622302 chr3:49547561 T/C cg21582582 chr3:182698605 DCUN1D1 -0.51 -6.47 -0.34 3.47e-10 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs6740322 0.748 rs13432574 chr2:43544328 A/G cg06169590 chr2:43455088 ZFP36L2;LOC100129726 -0.62 -7.55 -0.38 4.39e-13 Coronary artery disease; CRC cis rs1862618 0.853 rs252909 chr5:56121131 T/C cg03609598 chr5:56110824 MAP3K1 -0.85 -10.42 -0.5 3.63e-22 Initial pursuit acceleration; CRC cis rs116095464 0.558 rs7713524 chr5:276200 C/T cg22857025 chr5:266934 NA 1.27 16.78 0.68 4.34e-46 Breast cancer; CRC cis rs2013441 1.000 rs11654025 chr17:20198160 A/T cg13482628 chr17:19912719 NA -0.38 -5.62 -0.3 4.04e-8 Obesity-related traits; CRC cis rs2204008 0.805 rs11179579 chr12:38213957 A/C cg26384229 chr12:38710491 ALG10B 0.68 9.04 0.45 1.4e-17 Bladder cancer; CRC cis rs7258465 0.965 rs7256534 chr19:18586791 C/T cg01065977 chr19:18549689 ISYNA1 -0.41 -6.36 -0.33 6.7e-10 Breast cancer; CRC cis rs3733585 0.699 rs10001964 chr4:9959275 C/T cg00071950 chr4:10020882 SLC2A9 -0.55 -9.79 -0.47 5.05e-20 Cleft plate (environmental tobacco smoke interaction); CRC cis rs9611565 0.512 rs9611667 chr22:42187015 C/T cg03806693 chr22:41940476 POLR3H -1.07 -12.87 -0.58 5.64e-31 Vitiligo; CRC cis rs911119 0.913 rs13037490 chr20:23583725 T/C cg16589663 chr20:23618590 CST3 0.58 6.97 0.36 1.71e-11 Chronic kidney disease; CRC cis rs7659604 0.539 rs11098646 chr4:122729301 T/C cg19748678 chr4:122722346 EXOSC9 0.65 10.16 0.49 2.75e-21 Type 2 diabetes; CRC trans rs931812 0.757 rs4734492 chr8:101901901 C/T cg20993868 chr7:22813445 NA -0.44 -9.21 -0.45 3.84e-18 Attention deficit hyperactivity disorder and conduct disorder; CRC cis rs9300255 0.537 rs2695482 chr12:123623174 C/T cg00376283 chr12:123451042 ABCB9 0.6 8.18 0.41 6.43e-15 Neutrophil percentage of white cells; CRC cis rs12044355 0.892 rs1538974 chr1:231828596 A/C cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.45 -6.26 -0.33 1.21e-9 Alzheimer's disease; CRC cis rs6076065 0.963 rs999072 chr20:23347553 C/T cg11657817 chr20:23433608 CST11 0.37 5.89 0.31 9.36e-9 Facial morphology (factor 15, philtrum width); CRC cis rs10504229 1.000 rs74546828 chr8:58171678 A/G cg22535103 chr8:58192502 C8orf71 -0.82 -12.27 -0.56 9.63e-29 Developmental language disorder (linguistic errors); CRC cis rs709400 0.597 rs1013650 chr14:103909203 G/A cg12935359 chr14:103987150 CKB -0.47 -7.63 -0.39 2.58e-13 Body mass index; CRC trans rs4621152 1.000 rs11894340 chr2:217917167 A/G cg03559682 chr11:6439864 APBB1 -0.31 -5.97 -0.31 6.17e-9 Gut microbiota (bacterial taxa); CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg13348770 chr6:122720548 HSF2 0.47 6.26 0.33 1.17e-9 Anxiety disorder; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg01241850 chr9:138798996 CAMSAP1 0.39 6.04 0.32 4.17e-9 Intelligence (multi-trait analysis); CRC cis rs3018066 0.666 rs6844324 chr4:107046619 C/T cg01869342 chr4:106983673 TBCK 0.47 6.08 0.32 3.3e-9 Cancer; CRC cis rs9311474 0.713 rs352167 chr3:52238656 C/T cg08222913 chr3:52553049 STAB1 0.34 6.48 0.34 3.35e-10 Electroencephalogram traits; CRC trans rs9858542 0.953 rs6997 chr3:49453834 C/T cg21665057 chr3:196295764 WDR53;FBXO45 -0.62 -8.45 -0.42 9.83e-16 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs6933660 0.646 rs3736176 chr6:151773320 T/A cg17179660 chr6:151773299 C6orf211;RMND1 -0.45 -6.93 -0.36 2.29e-11 Menarche (age at onset); CRC trans rs7395662 0.864 rs10838951 chr11:48571088 T/G cg21153622 chr11:89784906 NA -0.44 -7.0 -0.36 1.47e-11 HDL cholesterol; CRC cis rs875971 0.862 rs778684 chr7:65836403 A/T cg00343986 chr7:65444356 GUSB 0.42 5.94 0.31 7.35e-9 Aortic root size; CRC cis rs17401966 1.000 rs12141416 chr1:10327867 A/G cg19773385 chr1:10388646 KIF1B -0.7 -11.49 -0.54 6.38e-26 Hepatocellular carcinoma; CRC trans rs12478296 1.000 rs60533128 chr2:243028088 A/G cg18288967 chr1:45987694 PRDX1 0.68 6.59 0.34 1.79e-10 Obesity-related traits; CRC cis rs2549003 1.000 rs2070731 chr5:131819798 T/C cg00255919 chr5:131827918 IRF1 0.59 11.64 0.54 1.85e-26 Asthma (sex interaction); CRC cis rs7666738 0.830 rs10001702 chr4:99065160 T/G cg05340658 chr4:99064831 C4orf37 0.6 9.29 0.46 2.1e-18 Colonoscopy-negative controls vs population controls; CRC cis rs34172651 0.917 rs200539 chr16:24735178 T/C cg00339695 chr16:24857497 SLC5A11 -0.29 -6.51 -0.34 2.88e-10 Intelligence (multi-trait analysis); CRC cis rs9488822 0.676 rs1999929 chr6:116381994 T/C cg05304507 chr6:116381966 FRK 0.31 8.43 0.42 1.09e-15 Cholesterol, total;LDL cholesterol; CRC cis rs8177253 1.000 rs1358023 chr3:133484393 T/C cg16262614 chr3:133464971 TF 0.33 5.85 0.31 1.17e-8 Iron status biomarkers; CRC cis rs17401966 0.838 rs4846206 chr1:10310258 G/C cg19773385 chr1:10388646 KIF1B -0.65 -10.66 -0.51 5.45e-23 Hepatocellular carcinoma; CRC cis rs2976388 0.609 rs2164308 chr8:143785659 A/G cg20041105 chr8:143859282 LYNX1 -0.45 -7.97 -0.4 2.56e-14 Urinary tract infection frequency; CRC trans rs2018683 0.707 rs1021689 chr7:28974223 G/T cg19402173 chr7:128379420 CALU -0.43 -6.2 -0.32 1.71e-9 Response to irinotecan and platinum-based chemotherapy in non-small-cell lung cancer; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg18996663 chr14:55595768 LGALS3 0.39 6.06 0.32 3.83e-9 Liver disease severity in Alagille syndrome; CRC cis rs1552244 0.872 rs35988239 chr3:10074145 G/T cg16606324 chr3:10149918 C3orf24 0.76 8.82 0.44 6.99e-17 Alzheimer's disease; CRC trans rs1005277 0.579 rs1780138 chr10:38501654 A/G cg11292332 chr7:45801988 SEPT13 -0.38 -7.02 -0.36 1.26e-11 Extrinsic epigenetic age acceleration; CRC cis rs8060686 0.516 rs7206792 chr16:68168200 C/G cg26727032 chr16:67993705 SLC12A4 -0.58 -8.83 -0.44 6.2e-17 HDL cholesterol;Metabolic syndrome; CRC cis rs10971721 0.643 rs10971702 chr9:33784102 C/T cg13495928 chr9:33750294 PRSS3 0.66 5.92 0.31 8.05e-9 Body mass index; CRC cis rs9467773 1.000 rs4713006 chr6:26519872 A/G cg09904177 chr6:26538194 HMGN4 0.86 14.68 0.63 7.34e-38 Intelligence (multi-trait analysis); CRC cis rs2289328 0.943 rs3803360 chr15:40662669 C/T cg13931752 chr15:40660718 DISP2 0.48 6.0 0.31 5.3300000000000004e-09 Intelligence (multi-trait analysis);Cognitive ability;Cognitive ability (multi-trait analysis); CRC cis rs2573652 0.723 rs4577068 chr15:100515959 T/A cg00587665 chr15:100533223 ADAMTS17 -0.45 -7.75 -0.39 1.16e-13 Height; CRC cis rs6500602 0.727 rs1477123 chr16:4560627 T/A cg14951292 chr16:4525986 HMOX2;NMRAL1 0.71 10.17 0.49 2.56e-21 Schizophrenia; CRC cis rs9650657 0.589 rs6985109 chr8:10761585 A/G cg27411982 chr8:10470053 RP1L1 0.41 5.96 0.31 6.63e-9 Neuroticism; CRC cis rs10229583 0.527 rs6979634 chr7:127323965 A/C cg01233922 chr7:127693937 SND1 0.46 6.86 0.35 3.51e-11 Type 2 diabetes; CRC cis rs2213920 0.568 rs6478166 chr9:118213548 T/C cg13918206 chr9:118159781 DEC1 0.6 5.85 0.31 1.16e-8 Docetaxel-induced peripheral neuropathy in metastatic castrate-resistant prostate cancer; CRC cis rs6500602 0.927 rs7200817 chr16:4480598 G/C cg14951292 chr16:4525986 HMOX2;NMRAL1 0.54 7.85 0.4 5.88e-14 Schizophrenia; CRC cis rs7951870 0.673 rs4606447 chr11:46691737 A/G cg19486271 chr11:47235900 DDB2 -0.43 -6.61 -0.34 1.59e-10 Schizophrenia; CRC cis rs2832191 0.791 rs57721945 chr21:30498744 T/C cg08807101 chr21:30365312 RNF160 -0.62 -9.68 -0.47 1.16e-19 Dental caries; CRC cis rs4665809 1.000 rs6546728 chr2:26276531 G/C cg26119090 chr2:26468346 HADHA;HADHB -0.67 -8.34 -0.42 2.07e-15 Gut microbiome composition (summer); CRC cis rs853679 1.000 rs2799077 chr6:28234597 C/T cg06470822 chr6:28175283 NA 0.65 6.64 0.34 1.26e-10 Depression; CRC cis rs911555 0.755 rs975892 chr14:103883349 A/T cg24130564 chr14:104152367 KLC1 -0.42 -5.74 -0.3 2.17e-8 Intelligence (multi-trait analysis); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg22805796 chr17:79829393 ARHGDIA 0.45 6.39 0.33 5.77e-10 Response to antipsychotic treatment; CRC cis rs4658101 0.815 rs11165013 chr1:92051419 G/A cg24006770 chr1:92056542 NA 0.43 5.68 0.3 2.9e-8 Optic disc area;Vertical cup-disc ratio; CRC cis rs225245 0.791 rs7216391 chr17:34024706 G/A cg05299278 chr17:33885742 SLFN14 0.5 8.12 0.41 9.57e-15 Reticulocyte count;Reticulocyte fraction of red cells;High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells; CRC cis rs7707921 0.767 rs226196 chr5:81576965 C/A cg07807695 chr5:81608485 ATP6AP1L -0.48 -7.66 -0.39 2.16e-13 Breast cancer; CRC cis rs1784581 0.588 rs7752870 chr6:162422510 T/C cg17173639 chr6:162384350 PARK2 0.6 9.67 0.47 1.27e-19 Itch intensity from mosquito bite; CRC cis rs7659604 0.537 rs6815973 chr4:122663430 A/T cg19748678 chr4:122722346 EXOSC9 -0.56 -7.76 -0.39 1.11e-13 Type 2 diabetes; CRC cis rs4604732 0.578 rs12040725 chr1:247644697 T/A cg02104434 chr1:247694406 LOC148824;OR2C3 0.56 8.04 0.41 1.61e-14 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg21036854 chr14:77506705 NA 0.5 6.55 0.34 2.19e-10 Thyroid stimulating hormone; CRC cis rs7264396 0.887 rs6060431 chr20:34059337 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.37 -5.93 -0.31 7.54e-9 Total cholesterol levels; CRC cis rs3806843 0.735 rs801185 chr5:140068869 A/G cg19875535 chr5:140030758 IK -0.63 -10.64 -0.51 6.55e-23 Depressive symptoms (multi-trait analysis); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg19794706 chr14:75643232 TMED10 0.43 6.66 0.34 1.13e-10 Liver disease severity in Alagille syndrome; CRC cis rs853679 0.550 rs1233701 chr6:28168726 C/G cg06470822 chr6:28175283 NA -1.02 -16.08 -0.66 2.35e-43 Depression; CRC cis rs17166499 0.634 rs73070122 chr7:12887318 A/G cg12945054 chr7:12841881 NA 0.45 5.81 0.31 1.46e-8 Bipolar disorder and schizophrenia; CRC cis rs4727027 0.870 rs62507512 chr7:148799338 C/T cg23583168 chr7:148888333 NA -0.89 -14.83 -0.63 1.87e-38 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC cis rs11212617 1.000 rs652311 chr11:108240069 G/A cg14761454 chr11:108092087 ATM;NPAT 0.44 6.76 0.35 6.12e-11 Response to metformin in type 2 diabetes (glycemic); CRC cis rs9291683 0.655 rs55941493 chr4:10100341 G/A cg11266682 chr4:10021025 SLC2A9 -0.42 -8.2 -0.41 5.35e-15 Bone mineral density; CRC cis rs1865760 0.534 rs2032444 chr6:26046744 T/G cg16482183 chr6:26056742 HIST1H1C 0.63 8.49 0.42 7.03e-16 Height; CRC cis rs9443645 0.901 rs9352683 chr6:79718795 T/G cg11833968 chr6:79620685 NA -0.35 -6.04 -0.32 4.19e-9 Intelligence (multi-trait analysis); CRC cis rs9486719 0.947 rs11153071 chr6:97039741 G/A cg18709589 chr6:96969512 KIAA0776 -0.51 -5.73 -0.3 2.31e-8 Migraine;Coronary artery disease; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg23182539 chr10:121355708 TIAL1 0.46 6.68 0.35 9.92e-11 Response to antipsychotic treatment; CRC cis rs6952808 0.624 rs60137119 chr7:2083664 A/G cg22963979 chr7:1858916 MAD1L1 -0.48 -6.7 -0.35 8.83e-11 Bipolar disorder and schizophrenia; CRC cis rs172166 0.538 rs1150686 chr6:28161271 T/G cg23161317 chr6:28129485 ZNF389 0.4 6.06 0.32 3.64e-9 Cardiac Troponin-T levels; CRC cis rs7552404 0.924 rs1146588 chr1:76229787 C/G cg03433033 chr1:76189801 ACADM 0.76 11.37 0.53 1.69e-25 Blood metabolite levels;Acylcarnitine levels; CRC cis rs10274279 1.000 rs6459798 chr7:157381735 C/T cg26886268 chr7:157387156 PTPRN2 -0.48 -5.84 -0.31 1.23e-8 Myopia (pathological); CRC trans rs13046373 0.905 rs4816372 chr21:32077414 A/T cg00694336 chr1:114301873 PHTF1 -0.44 -6.3 -0.33 9.67e-10 HDL cholesterol; CRC cis rs561341 1.000 rs530715 chr17:30320544 T/G cg12193833 chr17:30244370 NA -0.63 -8.06 -0.41 1.39e-14 Hip circumference adjusted for BMI; CRC cis rs7289126 0.966 rs5995554 chr22:38630272 T/C cg25457927 chr22:38595422 NA -0.3 -5.92 -0.31 8.18e-9 Mammographic density (dense area);Percent mammographic density; CRC cis rs7772486 0.686 rs1569540 chr6:146069112 A/G cg05347473 chr6:146136440 FBXO30 -0.37 -5.66 -0.3 3.25e-8 Lobe attachment (rater-scored or self-reported); CRC cis rs7312933 0.933 rs4534650 chr12:42444222 A/G cg17420585 chr12:42539391 GXYLT1 -0.44 -6.32 -0.33 8.41e-10 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CRC cis rs2237234 0.848 rs2237235 chr6:26391395 A/G cg14345882 chr6:26364793 BTN3A2 0.55 6.09 0.32 3.07e-9 Autism spectrum disorder or schizophrenia; CRC trans rs3743266 0.613 rs2414669 chr15:60708824 A/G cg21176127 chr14:100795263 C14orf68 0.21 5.96 0.31 6.42e-9 Menarche (age at onset); CRC cis rs7781266 0.793 rs62470021 chr7:133273036 T/A cg03336402 chr7:133662267 EXOC4 0.49 5.75 0.3 2.02e-8 Educational attainment (college completion); CRC cis rs9846480 0.598 rs35219044 chr3:138056177 T/C cg25476813 chr3:138050155 TXNDC6 -0.4 -5.91 -0.31 8.37e-9 Whole-brain volume (Alzheimer's disease interaction); CRC cis rs2019137 0.836 rs4848318 chr2:113953952 T/C cg07594247 chr2:113993304 PAX8;LOC440839;LOC654433 -0.38 -5.6 -0.3 4.42e-8 Lymphocyte counts; CRC cis rs7618915 0.570 rs2336145 chr3:52629750 A/C cg05573699 chr3:52720067 GNL3;PBRM1 -0.44 -6.21 -0.32 1.57e-9 Bipolar disorder; CRC cis rs8036030 0.604 rs11856835 chr15:74716174 G/A cg05926586 chr15:74592786 CCDC33 0.32 5.64 0.3 3.66e-8 Airflow obstruction; CRC cis rs4919694 1.000 rs11191473 chr10:104710710 C/G cg04362960 chr10:104952993 NT5C2 1.11 10.4 0.5 4.45e-22 Arsenic metabolism; CRC cis rs2688608 0.653 rs12775558 chr10:75570868 G/A cg16540259 chr10:75572220 NDST2 0.38 6.1 0.32 2.99e-9 Inflammatory bowel disease; CRC cis rs1113500 0.933 rs4590700 chr1:108638344 G/T cg06207961 chr1:108661230 NA 0.39 5.72 0.3 2.41e-8 Growth-regulated protein alpha levels; CRC cis rs4713118 0.869 rs10214440 chr6:27702440 A/C cg26587870 chr6:27730563 NA -0.44 -6.83 -0.35 4.18e-11 Parkinson's disease; CRC cis rs7666738 0.830 rs35491210 chr4:99003364 T/C cg05340658 chr4:99064831 C4orf37 0.58 8.94 0.44 2.79e-17 Colonoscopy-negative controls vs population controls; CRC cis rs1552244 1.000 rs6764168 chr3:10123805 A/G cg13047869 chr3:10149882 C3orf24 0.57 7.83 0.4 6.96e-14 Alzheimer's disease; CRC cis rs12692738 0.526 rs355866 chr2:165630823 G/A cg03182029 chr2:165697222 COBLL1 0.5 5.86 0.31 1.11e-8 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);Waist-to-hip ratio adjusted for BMI in non-smokers;Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction);Waist-to-hip ratio adjusted for body mass index; CRC cis rs4660306 0.961 rs2991966 chr1:45999503 G/A cg03123370 chr1:45965343 CCDC163P;MMACHC -0.54 -7.5 -0.38 6.06e-13 Homocysteine levels; CRC cis rs10504229 1.000 rs67913746 chr8:58177825 A/G cg02290350 chr8:58132656 NA -0.42 -5.96 -0.31 6.62e-9 Developmental language disorder (linguistic errors); CRC cis rs7512552 0.839 rs11577600 chr1:150407443 G/A cg15654264 chr1:150340011 RPRD2 0.59 8.42 0.42 1.14e-15 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); CRC cis rs735539 1.000 rs9579929 chr13:21282724 C/T cg04906043 chr13:21280425 IL17D 0.49 7.82 0.4 7.47e-14 Dental caries; CRC cis rs13108904 0.539 rs13145722 chr4:1338422 T/A cg24560729 chr4:1342394 KIAA1530 0.38 6.18 0.32 1.86e-9 Obesity-related traits; CRC cis rs9534288 0.912 rs9526135 chr13:46624992 G/C cg15192986 chr13:46630673 CPB2 -0.74 -10.26 -0.49 1.29e-21 Blood protein levels; CRC cis rs853679 0.517 rs1853097 chr6:28058635 A/G cg15845792 chr6:28175446 NA 0.98 13.03 0.58 1.45e-31 Depression; CRC cis rs9381040 0.610 rs742495 chr6:41018233 A/G cg25110423 chr6:41068646 NFYA;LOC221442 -0.37 -5.75 -0.3 2.08e-8 Alzheimer's disease (late onset); CRC cis rs9648716 0.766 rs534348 chr7:140782235 A/G cg10747023 chr7:140774559 NA 0.44 5.9 0.31 8.86e-9 Type 2 diabetes; CRC cis rs853679 0.517 rs4713141 chr6:28101678 G/C cg23161317 chr6:28129485 ZNF389 0.53 6.54 0.34 2.37e-10 Depression; CRC cis rs968567 0.528 rs174582 chr11:61607168 A/G cg06781209 chr11:61594997 FADS2 -0.6 -7.57 -0.39 3.83e-13 Blood metabolite levels;Rheumatoid arthritis;Vitiligo;Glycerophospholipid levels; CRC cis rs989128 0.572 rs6504674 chr17:48630814 T/C cg24438145 chr17:48624694 SPATA20 0.44 6.26 0.33 1.2e-9 Type 2 diabetes; CRC cis rs9322193 0.923 rs9689716 chr6:149976798 G/A cg13206674 chr6:150067644 NUP43 0.65 9.81 0.48 4.27e-20 Lung cancer; CRC trans rs6472235 0.837 rs60520895 chr8:66930290 C/T cg07884673 chr3:53033167 SFMBT1 -0.45 -6.03 -0.32 4.47e-9 Myopia (pathological);Plateletcrit; CRC cis rs4731207 0.564 rs1011721 chr7:124605159 G/T cg23710748 chr7:124431027 NA -0.38 -6.08 -0.32 3.35e-9 Cutaneous malignant melanoma; CRC cis rs9303280 0.806 rs12232497 chr17:38040119 T/C cg11212589 chr17:38028394 ZPBP2 0.41 7.59 0.39 3.28e-13 Self-reported allergy; CRC cis rs4332037 0.575 rs55952733 chr7:2070680 G/A cg23422044 chr7:1970798 MAD1L1 -0.55 -6.63 -0.34 1.35e-10 Bipolar disorder; CRC cis rs4660306 0.961 rs1494813 chr1:45957290 T/C cg03123370 chr1:45965343 CCDC163P;MMACHC -0.56 -7.85 -0.4 5.99e-14 Homocysteine levels; CRC cis rs7917772 0.539 rs12572775 chr10:104285594 A/T cg11453585 chr10:104263688 ACTR1A;SUFU -0.79 -13.99 -0.61 3.22e-35 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC cis rs77861329 1.000 rs6781635 chr3:52125343 A/G cg08692210 chr3:52188851 WDR51A 0.87 8.26 0.41 3.7e-15 Macrophage inflammatory protein 1b levels; CRC cis rs2243480 1.000 rs6964530 chr7:65718851 G/C cg12463550 chr7:65579703 CRCP -0.68 -6.08 -0.32 3.29e-9 Diabetic kidney disease; CRC cis rs875971 0.862 rs6962717 chr7:65883735 G/A cg18876405 chr7:65276391 NA 0.51 8.56 0.43 4.3e-16 Aortic root size; CRC cis rs6500602 0.627 rs3848372 chr16:4587875 C/A cg06139259 chr16:4526053 HMOX2;NMRAL1 0.45 6.08 0.32 3.28e-9 Schizophrenia; CRC cis rs57590327 0.716 rs4352391 chr3:81802318 T/C cg07356753 chr3:81810745 GBE1 -0.62 -7.68 -0.39 1.84e-13 Extraversion; CRC cis rs7264396 0.635 rs6058358 chr20:34492560 A/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.58 -9.92 -0.48 1.82e-20 Total cholesterol levels; CRC cis rs611744 0.647 rs579162 chr8:109254842 A/G cg21045802 chr8:109455806 TTC35 0.42 6.65 0.34 1.24e-10 Dupuytren's disease; CRC cis rs7707921 1.000 rs6888977 chr5:81533735 C/T cg17942617 chr5:81327376 ATG10 -0.4 -5.99 -0.31 5.46e-9 Breast cancer; CRC cis rs1728785 0.901 rs1728787 chr16:68593042 G/C cg02972257 chr16:68554789 NA -0.6 -7.54 -0.38 4.71e-13 Ulcerative colitis; CRC trans rs61931739 0.500 rs6488218 chr12:34452587 T/C cg26384229 chr12:38710491 ALG10B 0.59 8.68 0.43 1.93e-16 Morning vs. evening chronotype; CRC cis rs9560113 1.000 rs9560105 chr13:112175363 A/T cg10483660 chr13:112241077 NA -0.39 -6.48 -0.34 3.45e-10 Menarche (age at onset); CRC cis rs7259376 0.936 rs8111537 chr19:22535545 C/G cg02657401 chr19:22469223 NA -0.31 -7.05 -0.36 1.08e-11 Menopause (age at onset); CRC cis rs7258465 1.000 rs10164319 chr19:18569833 G/A cg06462663 chr19:18546047 ISYNA1 0.47 7.08 0.36 8.6e-12 Breast cancer; CRC trans rs11098499 0.738 rs10026493 chr4:120384194 C/G cg25214090 chr10:38739885 LOC399744 0.66 10.55 0.5 1.36e-22 Corneal astigmatism; CRC trans rs7615952 0.512 rs34651730 chr3:125358640 T/C cg21747405 chr11:67723411 NA -0.58 -9.13 -0.45 6.88e-18 Blood pressure (smoking interaction); CRC cis rs1167827 1.000 rs1167827 chr7:75163169 A/G cg04978709 chr7:75101039 POM121C 0.4 5.75 0.3 2.03e-8 Body mass index;BMI (adjusted for smoking behaviour);BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs17767392 0.881 rs34061264 chr14:71785276 A/G cg13720639 chr14:72061746 SIPA1L1 -0.45 -6.0 -0.31 5.14e-9 Mitral valve prolapse; CRC trans rs2228479 0.850 rs17227263 chr16:89810598 G/A cg21302420 chr1:112162376 RAP1A 0.72 5.96 0.31 6.38e-9 Skin colour saturation; CRC trans rs2303319 0.504 rs41267437 chr2:162627391 G/A cg04551154 chr10:95462393 C10orf4 -0.74 -5.98 -0.31 5.91e-9 Cognitive function; CRC cis rs9649213 0.574 rs7802541 chr7:97933855 C/A cg00277769 chr7:97922759 BAIAP2L1 -0.56 -9.51 -0.46 4.19e-19 Prostate cancer (SNP x SNP interaction); CRC cis rs4665809 1.000 rs1560868 chr2:26281459 A/T cg04944784 chr2:26401820 FAM59B 0.67 8.78 0.44 9.2e-17 Gut microbiome composition (summer); CRC cis rs2836974 0.897 rs13339986 chr21:40605982 T/C cg07074390 chr21:40555500 PSMG1 -0.47 -6.29 -0.33 1.03e-9 Cognitive function; CRC cis rs1552244 1.000 rs9834980 chr3:10065528 G/A cg13047869 chr3:10149882 C3orf24 0.51 7.07 0.36 9.31e-12 Alzheimer's disease; CRC cis rs3741151 0.686 rs7944346 chr11:73244230 C/T cg17517138 chr11:73019481 ARHGEF17 0.52 5.65 0.3 3.55e-8 GIP levels in response to oral glucose tolerance test (120 minutes); CRC cis rs1129187 0.755 rs9462855 chr6:42925936 G/C cg09436375 chr6:42928200 GNMT -0.36 -6.67 -0.34 1.11e-10 Alzheimer's disease in APOE e4+ carriers; CRC cis rs7493 0.853 rs35686517 chr7:95052611 G/A cg20119798 chr7:94954144 PON1 -0.52 -6.48 -0.34 3.39e-10 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs4926298 1.000 rs10423745 chr19:13176815 T/C cg11738485 chr19:12877000 HOOK2 -0.43 -5.92 -0.31 8.27e-9 Bipolar disorder; CRC cis rs3087591 0.708 rs964288 chr17:29679246 G/A cg24425628 chr17:29625626 OMG;NF1 0.7 12.97 0.58 2.37e-31 Hip circumference; CRC cis rs9875589 0.509 rs2731305 chr3:14081342 T/C cg14375111 chr3:14165186 TMEM43;CHCHD4 0.4 6.22 0.32 1.54e-9 Ovarian reserve; CRC trans rs45509595 0.841 rs401754 chr6:27782538 T/A cg16898833 chr6:26189333 HIST1H4D 0.72 6.46 0.34 3.84e-10 Breast cancer; CRC cis rs806215 0.951 rs327516 chr7:127255795 C/G cg25922125 chr7:127225783 GCC1 0.54 6.12 0.32 2.7e-9 Type 2 diabetes; CRC cis rs172166 0.694 rs203876 chr6:28046673 T/C cg15845792 chr6:28175446 NA 0.78 11.62 0.54 2.13e-26 Cardiac Troponin-T levels; CRC cis rs3760982 0.935 rs10422990 chr19:44295273 C/T cg11993925 chr19:44307056 LYPD5 0.47 7.76 0.39 1.07e-13 Breast cancer (estrogen-receptor negative);Breast cancer; CRC cis rs11105298 0.891 rs10858900 chr12:89925081 C/A cg08166232 chr12:89918718 WDR51B;GALNT4 -0.62 -7.62 -0.39 2.71e-13 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; CRC cis rs992157 0.798 rs1017698 chr2:219170525 A/G cg00012203 chr2:219082015 ARPC2 -0.43 -6.6 -0.34 1.63e-10 Colorectal cancer; CRC cis rs6540556 0.723 rs11119336 chr1:209930585 G/C cg05527609 chr1:210001259 C1orf107 -0.58 -6.5 -0.34 2.94e-10 Red blood cell count; CRC cis rs769267 0.965 rs2315024 chr19:19423817 T/A cg17414380 chr19:19431394 KIAA0892;SF4 0.42 5.69 0.3 2.78e-8 Tonsillectomy; CRC cis rs7927592 0.672 rs10501398 chr11:68331715 C/G cg16797656 chr11:68205561 LRP5 -0.45 -8.17 -0.41 6.8e-15 Total body bone mineral density; CRC cis rs7777484 0.500 rs2533885 chr7:2835655 C/T cg19717773 chr7:2847554 GNA12 -0.52 -9.28 -0.46 2.26e-18 Height; CRC cis rs9900062 0.546 rs2676289 chr17:62705738 A/G cg02097616 chr17:62675921 NA -0.5 -7.07 -0.36 9.46e-12 QT interval; CRC cis rs7781266 0.895 rs17658042 chr7:133302371 G/T cg03336402 chr7:133662267 EXOC4 0.52 5.94 0.31 7.23e-9 Educational attainment (college completion); CRC cis rs6747952 0.899 rs4663856 chr2:239089624 C/A cg07480446 chr2:239069576 NA -0.36 -6.74 -0.35 7.04e-11 Mean corpuscular hemoglobin concentration; CRC cis rs11628318 0.660 rs12887323 chr14:103083322 T/C cg23071808 chr14:103021642 NA -0.64 -7.25 -0.37 2.99e-12 Platelet count; CRC cis rs10197940 0.710 rs4500942 chr2:152334580 A/G cg06191203 chr2:152266755 RIF1 -0.73 -11.12 -0.52 1.37e-24 Lung cancer; CRC cis rs10504073 0.647 rs7817571 chr8:50003218 T/C cg00325661 chr8:49890786 NA 0.45 8.25 0.41 3.92e-15 Blood metabolite ratios; CRC cis rs11212617 1.000 rs624366 chr11:108154097 C/G cg01991180 chr11:108092276 ATM;NPAT -0.41 -6.02 -0.32 4.56e-9 Response to metformin in type 2 diabetes (glycemic); CRC cis rs7727544 0.582 rs3805683 chr5:131535125 T/G cg02033258 chr5:131593261 PDLIM4 0.32 5.83 0.31 1.32e-8 Blood metabolite levels; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg14363992 chr6:27776350 HIST1H2AI;HIST1H3H;HIST1H2BL 0.44 6.31 0.33 9.11e-10 Response to antipsychotic treatment; CRC cis rs1707322 1.000 rs6677777 chr1:46475836 A/G cg03146154 chr1:46216737 IPP 0.58 8.02 0.4 1.87e-14 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC trans rs7395662 0.895 rs1945183 chr11:48502427 T/A cg21153622 chr11:89784906 NA -0.48 -7.72 -0.39 1.44e-13 HDL cholesterol; CRC cis rs4481887 0.741 rs7417519 chr1:248550370 C/T cg26353448 chr1:248524236 OR2T4 0.3 5.78 0.3 1.77e-8 Common traits (Other); CRC trans rs11098499 0.644 rs7693919 chr4:120540571 G/A cg25214090 chr10:38739885 LOC399744 0.58 9.19 0.45 4.44e-18 Corneal astigmatism; CRC cis rs933688 1.000 rs10058025 chr5:90689052 A/G cg26981201 chr5:90679533 LOC100129716;ARRDC3 1.02 15.59 0.65 1.97e-41 Smoking behavior; CRC cis rs2455601 0.744 rs7938995 chr11:8975675 T/G cg21881798 chr11:8931708 C11orf17;ST5 -0.5 -5.86 -0.31 1.15e-8 Schizophrenia; CRC cis rs11212617 0.967 rs662578 chr11:108194557 C/T cg14761454 chr11:108092087 ATM;NPAT 0.43 6.43 0.33 4.62e-10 Response to metformin in type 2 diabetes (glycemic); CRC cis rs4474465 1.000 rs10899523 chr11:78190808 C/T cg27205649 chr11:78285834 NARS2 -0.46 -5.83 -0.31 1.32e-8 Alzheimer's disease (survival time); CRC cis rs4654899 0.931 rs7543140 chr1:21180250 G/A cg02927042 chr1:21476669 EIF4G3 0.4 6.42 0.33 4.83e-10 Superior frontal gyrus grey matter volume; CRC cis rs10221833 0.602 rs429376 chr2:165634361 A/G cg03182029 chr2:165697222 COBLL1 0.5 5.77 0.3 1.79e-8 Response to statin therapy; CRC cis rs7666738 0.791 rs11735105 chr4:98937357 C/T cg05340658 chr4:99064831 C4orf37 0.6 9.35 0.46 1.41e-18 Colonoscopy-negative controls vs population controls; CRC trans rs1814175 0.791 rs9787917 chr11:49937281 C/T cg15704280 chr7:45808275 SEPT13 -1.02 -20.57 -0.75 5.09e-61 Height; CRC cis rs10504229 1.000 rs59071610 chr8:58186301 A/C cg02290350 chr8:58132656 NA -0.41 -5.86 -0.31 1.12e-8 Developmental language disorder (linguistic errors); CRC trans rs1549309 0.767 rs9313387 chr5:167173269 C/T cg15316583 chr2:169312568 LASS6 0.53 6.39 0.33 5.6e-10 Dietary macronutrient intake; CRC cis rs910316 0.763 rs175036 chr14:75464295 C/T cg11812906 chr14:75593930 NEK9 -0.57 -8.73 -0.43 1.27e-16 Height; CRC trans rs4955793 0.585 rs9854435 chr3:178624727 G/A cg11644478 chr21:40555479 PSMG1 0.66 6.15 0.32 2.24e-9 Post-traumatic stress disorder (asjusted for relatedness); CRC cis rs7493 1.000 rs1034809 chr7:95051652 G/A cg19678392 chr7:94953810 PON1 -0.59 -7.31 -0.37 2.09e-12 Yu-Zhi constitution type in type 2 diabetes; CRC trans rs800082 0.516 rs1182797 chr3:144241495 T/C cg24215973 chr2:240111563 HDAC4 0.46 6.54 0.34 2.34e-10 Smoking behavior; CRC cis rs13256369 0.951 rs10503394 chr8:8565775 A/G cg18904891 chr8:8559673 CLDN23 0.55 7.39 0.38 1.19e-12 Obesity-related traits; CRC cis rs1018836 0.923 rs13259842 chr8:91550819 A/G cg16814680 chr8:91681699 NA -0.76 -12.67 -0.57 3.03e-30 Ejection fraction in Tripanosoma cruzi seropositivity; CRC cis rs10946940 0.965 rs4713112 chr6:27516833 G/T cg06470822 chr6:28175283 NA -0.52 -7.15 -0.37 5.64e-12 Systemic lupus erythematosus; CRC cis rs4253772 0.591 rs6520010 chr22:46721223 G/A cg03482458 chr22:46692211 CN5H6.4;GTSE1 0.57 7.79 0.39 8.63e-14 LDL cholesterol;Cholesterol, total; CRC cis rs7113874 0.655 rs7945659 chr11:8529925 A/T cg17679104 chr11:8615758 STK33 -0.35 -5.71 -0.3 2.58e-8 Body mass index in physically active individuals;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs4728302 0.838 rs755664 chr7:133596671 C/G cg10665199 chr7:133106180 EXOC4 0.39 5.79 0.3 1.66e-8 Intelligence;Intelligence (multi-trait analysis); CRC cis rs853679 0.517 rs9380050 chr6:28048538 A/G cg02631126 chr6:28058918 ZSCAN12L1 0.29 6.1 0.32 2.95e-9 Depression; CRC cis rs4077515 0.577 rs10870165 chr9:139316601 C/T cg14019695 chr9:139328340 INPP5E 0.41 6.01 0.31 4.95e-9 Ulcerative colitis;IgA nephropathy;Inflammatory bowel disease;Crohn's disease; CRC cis rs2976388 0.525 rs2016749 chr8:143836118 G/A cg05569086 chr8:143859399 LYNX1 -0.54 -9.38 -0.46 1.12e-18 Urinary tract infection frequency; CRC cis rs1153858 1.000 rs1890565 chr15:45663299 T/C cg10760299 chr15:45669010 GATM 0.51 8.12 0.41 9.48e-15 Homoarginine levels; CRC cis rs709400 0.663 rs11623869 chr14:103883633 G/T cg12935359 chr14:103987150 CKB -0.51 -7.95 -0.4 2.93e-14 Body mass index; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg24543526 chr10:75911479 ADK;AP3M1 0.51 7.29 0.37 2.36e-12 Response to antipsychotic treatment; CRC trans rs6456156 0.792 rs10946213 chr6:167516095 A/G cg13751927 chr19:17000885 F2RL3 -0.36 -5.97 -0.31 6.08e-9 Primary biliary cholangitis; CRC cis rs4919694 1.000 rs12245343 chr10:104774050 A/G cg04362960 chr10:104952993 NT5C2 1.17 10.93 0.52 6.24e-24 Arsenic metabolism; CRC cis rs7804356 1.000 rs12535784 chr7:26882067 G/A cg03456212 chr7:26904342 SKAP2 -0.49 -5.62 -0.3 4.09e-8 Type 1 diabetes; CRC trans rs208520 1.000 rs72884025 chr6:66994185 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.91 11.06 0.52 2.21e-24 Exhaled nitric oxide output; CRC cis rs703980 0.786 rs703982 chr10:80942721 C/T cg20744163 chr10:80999841 ZMIZ1 -0.37 -6.55 -0.34 2.19e-10 Type 2 diabetes; CRC cis rs10256972 0.591 rs10229680 chr7:1158565 C/T cg03923535 chr7:1197113 ZFAND2A 0.67 9.45 0.46 6.77e-19 Longevity;Endometriosis; CRC cis rs11711311 0.955 rs9866806 chr3:113379865 C/G cg06805542 chr3:113465803 ATP6V1A;NAA50 0.52 6.6 0.34 1.67e-10 IgG glycosylation; CRC trans rs9393777 0.920 rs13191227 chr6:27390115 G/C cg06606381 chr12:133084897 FBRSL1 -1.12 -7.45 -0.38 8.43e-13 Intelligence (multi-trait analysis); CRC cis rs7208859 0.623 rs7212991 chr17:29143749 T/C cg01831904 chr17:28903510 LRRC37B2 -0.62 -6.41 -0.33 5.13e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs853679 0.760 rs9393910 chr6:28208192 C/G cg25164649 chr6:28176230 NA 0.55 5.75 0.3 2e-8 Depression; CRC cis rs10971721 0.822 rs72725377 chr9:33842226 T/C cg13495928 chr9:33750294 PRSS3 0.55 5.9 0.31 9.17e-9 Body mass index; CRC cis rs910316 1.000 rs175512 chr14:75523382 T/C cg08847533 chr14:75593920 NEK9 -0.92 -17.28 -0.69 4.8e-48 Height; CRC trans rs10242455 0.702 rs6974831 chr7:99131605 A/G cg09045935 chr12:6379348 NA 1.16 9.03 0.45 1.47e-17 Blood metabolite levels; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg18073423 chr4:9514864 NA 0.39 6.29 0.33 1.01e-9 Myopia (pathological); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg05602987 chr16:28834702 ATXN2L 0.44 7.13 0.37 6.33e-12 Liver disease severity in Alagille syndrome; CRC cis rs6724607 1.000 rs10165399 chr2:191441595 A/G cg10560079 chr2:191398806 TMEM194B 0.47 6.76 0.35 6.36e-11 Pulse pressure; CRC cis rs9527 0.590 rs7898770 chr10:104756636 A/G cg15744005 chr10:104629667 AS3MT 0.29 5.89 0.31 9.79e-9 Arsenic metabolism; CRC cis rs262150 0.659 rs2527237 chr7:158798494 A/G cg12590608 chr7:158785262 NA -0.36 -6.37 -0.33 6.33e-10 Facial morphology (factor 20); CRC cis rs1046896 0.520 rs8074086 chr17:80818460 A/C cg03160526 chr17:80928410 B3GNTL1 0.59 8.04 0.41 1.69e-14 Glycated hemoglobin levels; CRC cis rs5758511 0.689 rs17002947 chr22:42688532 C/T cg00645731 chr22:42541494 CYP2D7P1 -0.56 -8.28 -0.42 3.04e-15 Birth weight; CRC cis rs1008375 1.000 rs3815414 chr4:17606659 A/G cg16339924 chr4:17578868 LAP3 -0.52 -6.92 -0.36 2.36e-11 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs155076 0.938 rs261375 chr13:21871882 A/G cg06138931 chr13:21896616 NA 0.48 5.63 0.3 3.91e-8 White matter hyperintensity burden; CRC cis rs6545883 0.868 rs7594191 chr2:61840018 A/G cg15711740 chr2:61764176 XPO1 0.51 7.03 0.36 1.17e-11 Tuberculosis; CRC cis rs4819052 0.851 rs28616694 chr21:46674786 G/C cg02159808 chr21:46707872 POFUT2;LOC642852 0.53 6.99 0.36 1.55e-11 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs10504229 0.562 rs2014516 chr8:58128288 C/A cg02290350 chr8:58132656 NA -0.58 -8.16 -0.41 7.29e-15 Developmental language disorder (linguistic errors); CRC cis rs9372498 0.536 rs17424234 chr6:118808521 A/G cg01339444 chr6:118972232 C6orf204 0.53 5.86 0.31 1.12e-8 Diastolic blood pressure; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg25392384 chr7:150102268 LOC728743 0.43 6.14 0.32 2.38e-9 Anxiety disorder; CRC cis rs2976388 0.566 rs13250661 chr8:143804134 C/T cg20041105 chr8:143859282 LYNX1 -0.43 -7.16 -0.37 5.22e-12 Urinary tract infection frequency; CRC cis rs12024301 0.557 rs12042704 chr1:183614433 T/C cg11505048 chr1:183622726 RGL1;APOBEC4 0.81 7.14 0.37 5.93e-12 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs9372498 0.505 rs9489462 chr6:118927855 C/T cg24463073 chr6:118973353 C6orf204 0.49 6.37 0.33 6.29e-10 Diastolic blood pressure; CRC cis rs7149337 0.869 rs7159770 chr14:51691835 G/A cg23942311 chr14:51606299 NA 0.75 13.72 0.6 3.47e-34 Cancer; CRC cis rs7811142 1.000 rs11771419 chr7:99988403 A/G cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.16 16.99 0.68 6.28e-47 Platelet count; CRC cis rs9640161 0.789 rs4554381 chr7:150025567 G/A cg12556325 chr7:150026731 C7orf29;LRRC61 -0.4 -6.1 -0.32 2.96e-9 Blood protein levels;Circulating chemerin levels; CRC cis rs7647973 0.925 rs6769821 chr3:49244657 G/A cg20833759 chr3:49053208 WDR6;DALRD3 0.57 8.18 0.41 6.44e-15 Menarche (age at onset); CRC cis rs12188164 0.686 rs56279338 chr5:416118 G/A cg21972741 chr5:435613 AHRR 0.47 6.46 0.34 3.73e-10 Cystic fibrosis severity; CRC cis rs28386778 0.897 rs2584627 chr17:61901439 T/C cg06873352 chr17:61820015 STRADA 0.8 15.25 0.64 4.21e-40 Prudent dietary pattern; CRC cis rs6973256 0.543 rs13243553 chr7:133506955 A/G cg03336402 chr7:133662267 EXOC4 0.41 5.74 0.3 2.15e-8 Intelligence (multi-trait analysis); CRC cis rs7149337 0.805 rs2999355 chr14:51607084 A/G cg18683604 chr14:51561293 TRIM9 0.29 6.0 0.31 5.11e-9 Cancer; CRC cis rs2204008 0.774 rs7305085 chr12:38263511 C/T cg13010199 chr12:38710504 ALG10B 0.45 5.75 0.3 2.07e-8 Bladder cancer; CRC cis rs7429990 0.932 rs9862913 chr3:48016172 T/C cg11946769 chr3:48343235 NME6 0.43 5.71 0.3 2.58e-8 Educational attainment (years of education); CRC cis rs9914988 0.887 rs4795464 chr17:27146497 G/C cg07195577 chr17:27052828 TLCD1 0.41 5.92 0.31 7.89e-9 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs7412746 0.552 rs4970980 chr1:150864992 A/C cg15448220 chr1:150897856 SETDB1 0.46 6.78 0.35 5.42e-11 Melanoma; CRC cis rs9916302 0.718 rs10445306 chr17:37591422 A/G cg15445000 chr17:37608096 MED1 0.43 9.47 0.46 5.8e-19 Glomerular filtration rate (creatinine); CRC cis rs9372498 0.536 rs12333080 chr6:118845410 A/C cg22561889 chr6:118971681 C6orf204 0.51 6.65 0.34 1.26e-10 Diastolic blood pressure; CRC cis rs6912958 0.525 rs242262 chr6:88018057 A/C cg12350822 chr6:88032061 C6orf162;GJB7 0.47 9.5 0.46 4.38e-19 Monocyte percentage of white cells; CRC cis rs3096299 0.685 rs4785675 chr16:89539974 T/C cg02187348 chr16:89574699 SPG7 0.4 5.94 0.31 7.37e-9 Multiple myeloma (IgH translocation); CRC cis rs17234274 0.622 rs1947941 chr11:23237051 T/C cg05245346 chr11:23248277 NA 0.34 5.63 0.3 3.79e-8 Cancer; CRC cis rs9322193 0.923 rs9505823 chr6:149950035 A/C cg07701084 chr6:150067640 NUP43 0.55 8.02 0.4 1.91e-14 Lung cancer; CRC cis rs7527798 0.592 rs11118282 chr1:207832402 G/A cg21110645 chr1:207815933 NA -0.37 -5.88 -0.31 1.03e-8 Erythrocyte sedimentation rate; CRC cis rs3087591 0.639 rs757378 chr17:29722619 A/T cg24425628 chr17:29625626 OMG;NF1 -0.69 -12.27 -0.56 9.06e-29 Hip circumference; CRC cis rs9486719 0.895 rs4486019 chr6:96883814 T/C cg06623918 chr6:96969491 KIAA0776 -0.81 -9.51 -0.46 4.17e-19 Migraine;Coronary artery disease; CRC trans rs2303319 0.504 rs56100249 chr2:162415157 T/C cg22677401 chr17:46026860 NA -0.69 -6.05 -0.32 4e-9 Cognitive function; CRC trans rs10504390 0.656 rs80115097 chr8:66551520 T/G cg26403416 chr21:43771339 TFF2 0.59 6.13 0.32 2.49e-9 IgG glycosylation; CRC trans rs6600671 0.899 rs6674392 chr1:121260662 C/G cg09829573 chr1:144692074 NBPF9 -0.41 -6.12 -0.32 2.69e-9 Hip geometry; CRC cis rs6089584 0.854 rs6061985 chr20:60622362 T/C cg18761221 chr20:60518478 NA 0.43 6.94 0.36 2.12e-11 Body mass index; CRC cis rs870825 0.616 rs2310108 chr4:185639475 C/T cg04058563 chr4:185651563 MLF1IP 0.73 9.41 0.46 9.01e-19 Blood protein levels; CRC cis rs9911578 0.933 rs11868348 chr17:57179238 C/T cg12560992 chr17:57184187 TRIM37 0.95 18.15 0.71 1.64e-51 Intelligence (multi-trait analysis); CRC cis rs7712401 0.755 rs4283786 chr5:122101050 T/C cg18764291 chr5:122110994 SNX2 0.41 6.5 0.34 3.02e-10 Mean platelet volume; CRC cis rs12476592 0.571 rs112194 chr2:63876872 T/G cg10828910 chr2:63850056 LOC388955 0.49 6.15 0.32 2.22e-9 Childhood ear infection; CRC cis rs763121 0.853 rs5750652 chr22:39048316 A/G cg06544989 chr22:39130855 UNC84B 0.46 7.37 0.38 1.4e-12 Menopause (age at onset); CRC cis rs17270561 0.609 rs3922699 chr6:25734969 A/G cg16482183 chr6:26056742 HIST1H1C 0.83 10.58 0.5 1.07e-22 Iron status biomarkers; CRC trans rs7267979 0.934 rs6037085 chr20:25305202 C/T cg17903999 chr18:56338584 MALT1 0.42 7.02 0.36 1.24e-11 Liver enzyme levels (alkaline phosphatase); CRC cis rs763121 0.925 rs4821815 chr22:39105707 G/A cg06544989 chr22:39130855 UNC84B 0.49 7.99 0.4 2.25e-14 Menopause (age at onset); CRC cis rs992157 0.835 rs2292551 chr2:219143229 G/A cg00012203 chr2:219082015 ARPC2 -0.47 -7.16 -0.37 5.15e-12 Colorectal cancer; CRC cis rs10746514 1.000 rs1576618 chr1:232244331 A/G cg09506761 chr1:232265262 NA -0.43 -5.66 -0.3 3.34e-8 Response to statin therapy; CRC cis rs9372498 0.536 rs9489436 chr6:118873817 A/C cg07617317 chr6:118971624 C6orf204 0.5 6.21 0.32 1.56e-9 Diastolic blood pressure; CRC cis rs2721195 1.000 rs6599530 chr8:145677418 C/G cg15857475 chr8:145742913 RECQL4;LRRC14 -0.72 -12.34 -0.56 5.16e-29 Age at first birth; CRC cis rs7945705 0.902 rs10769979 chr11:9010659 C/T cg14711859 chr11:8959438 ASCL3 -0.42 -6.81 -0.35 4.67e-11 Hemoglobin concentration; CRC cis rs10751667 0.643 rs7395592 chr11:934094 C/G ch.11.42038R chr11:967971 AP2A2 0.61 10.34 0.5 6.76e-22 Alzheimer's disease (late onset); CRC cis rs62064224 0.530 rs8073708 chr17:30680493 T/C cg09324608 chr17:30823087 MYO1D 0.33 5.73 0.3 2.31e-8 Schizophrenia; CRC cis rs6484504 0.532 rs7117286 chr11:31283810 T/A cg14844989 chr11:31128820 NA -0.35 -6.21 -0.32 1.64e-9 Red blood cell count; CRC cis rs10887265 1 rs10887265 chr10:86015573 G/C cg04757499 chr10:86016597 RGR 0.62 11.1 0.52 1.61e-24 Myopia; CRC cis rs9372498 0.536 rs9489458 chr6:118920503 G/A cg07617317 chr6:118971624 C6orf204 0.49 6.07 0.32 3.58e-9 Diastolic blood pressure; CRC cis rs73200209 0.744 rs7974638 chr12:116462700 C/G cg01776926 chr12:116560359 MED13L -0.62 -7.54 -0.38 4.72e-13 Total body bone mineral density; CRC cis rs1127311 0.905 rs6702449 chr1:154583210 A/C cg17218026 chr1:154582156 ADAR 0.69 12.32 0.56 5.96e-29 C-reactive protein levels or triglyceride levels (pleiotropy); CRC cis rs9902453 0.868 rs12944395 chr17:28323499 A/G cg26525008 chr17:28256777 EFCAB5;SSH2 -0.7 -11.25 -0.53 4.65e-25 Coffee consumption (cups per day); CRC cis rs7553864 0.518 rs10747341 chr1:87627331 G/A cg09121047 chr1:87617328 LOC339524 0.51 8.4 0.42 1.33e-15 Smoking behavior; CRC cis rs9858542 0.953 rs35261698 chr3:49537839 C/G cg00383909 chr3:49044727 WDR6 0.44 5.68 0.3 2.91e-8 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs6502050 0.835 rs4789754 chr17:80091941 C/T cg09264619 chr17:80180166 NA -0.36 -6.08 -0.32 3.37e-9 Life satisfaction; CRC cis rs3806843 0.676 rs2563304 chr5:140072057 C/T cg19875535 chr5:140030758 IK -0.63 -10.35 -0.5 6.58e-22 Depressive symptoms (multi-trait analysis); CRC cis rs9287719 0.649 rs12104950 chr2:10732105 G/A cg00105475 chr2:10696890 NA 0.44 7.0 0.36 1.43e-11 Prostate cancer; CRC trans rs1005277 0.579 rs2474587 chr10:38420666 C/T cg11292332 chr7:45801988 SEPT13 -0.35 -6.3 -0.33 9.49e-10 Extrinsic epigenetic age acceleration; CRC cis rs9787249 0.957 rs2274949 chr1:40221067 G/A cg19912559 chr1:40204330 PPIE 0.52 7.8 0.4 8.27e-14 Blood protein levels; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg04611479 chr17:41910366 MPP3 0.47 6.14 0.32 2.41e-9 Anxiety disorder; CRC trans rs800082 0.839 rs17282884 chr3:144319905 C/T cg24215973 chr2:240111563 HDAC4 0.51 6.67 0.35 1.1e-10 Smoking behavior; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg14425428 chr9:130743818 FAM102A 0.44 6.61 0.34 1.56e-10 Response to antipsychotic treatment; CRC cis rs4629180 0.586 rs1509495 chr2:102134834 C/T cg01388757 chr2:102091195 RFX8 -0.37 -5.67 -0.3 3.21e-8 Chronic rhinosinusitis with nasal polyps; CRC cis rs1707322 0.964 rs785483 chr1:46559171 T/C cg06784218 chr1:46089804 CCDC17 -0.55 -9.67 -0.47 1.26e-19 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs4285028 0.656 rs2141487 chr3:121482765 A/G cg20356878 chr3:121714668 ILDR1 0.51 6.7 0.35 8.97e-11 Multiple sclerosis; CRC cis rs881375 0.967 rs2109895 chr9:123677827 C/T cg09586646 chr9:123605570 PSMD5;LOC253039 0.51 7.05 0.36 1.04e-11 Rheumatoid arthritis; CRC cis rs853679 0.546 rs200954 chr6:27838764 C/G cg15845792 chr6:28175446 NA 0.73 6.16 0.32 2.08e-9 Depression; CRC cis rs13091206 1 rs13091206 chr3:49238718 A/G cg20833759 chr3:49053208 WDR6;DALRD3 0.79 11.09 0.52 1.77e-24 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs1865760 0.663 rs9379815 chr6:25980116 T/A cg17691542 chr6:26056736 HIST1H1C 0.55 8.69 0.43 1.78e-16 Height; CRC cis rs2204008 0.683 rs11522927 chr12:38137537 C/T cg26384229 chr12:38710491 ALG10B 0.73 9.65 0.47 1.43e-19 Bladder cancer; CRC cis rs7726839 0.540 rs72703087 chr5:598029 C/T cg17948913 chr5:572064 NA 0.51 5.88 0.31 1.01e-8 Obesity-related traits; CRC cis rs7587476 0.505 rs777323 chr2:215738485 A/G cg04004882 chr2:215674386 BARD1 -0.58 -8.03 -0.4 1.73e-14 Neuroblastoma; CRC cis rs72781680 0.898 rs2339851 chr2:23938883 G/A cg08917208 chr2:24149416 ATAD2B 1.01 9.56 0.47 2.83e-19 Lymphocyte counts; CRC cis rs801193 1.000 rs6975195 chr7:66124774 T/A cg18876405 chr7:65276391 NA -0.61 -10.75 -0.51 2.66e-23 Aortic root size; CRC cis rs6088580 0.634 rs2225837 chr20:33005634 C/T cg08999081 chr20:33150536 PIGU -0.61 -11.52 -0.54 4.94e-26 Glomerular filtration rate (creatinine); CRC cis rs9325144 0.647 rs7980932 chr12:38921583 G/T cg26384229 chr12:38710491 ALG10B -0.5 -7.25 -0.37 3.02e-12 Morning vs. evening chronotype; CRC trans rs6550704 0.687 rs9865314 chr3:22634337 A/G cg00331096 chr20:22564947 FOXA2 -0.43 -6.54 -0.34 2.36e-10 Daytime sleep phenotypes; CRC cis rs7647973 1.000 rs1464569 chr3:49460350 A/G cg07636037 chr3:49044803 WDR6 0.65 8.16 0.41 7.21e-15 Menarche (age at onset); CRC cis rs477895 0.713 rs2282490 chr11:63962152 T/C cg05016508 chr11:63871570 FLRT1;MACROD1 0.54 6.94 0.36 2.08e-11 Mean platelet volume; CRC cis rs9649213 0.574 rs3801257 chr7:97991792 A/G cg21770322 chr7:97807741 LMTK2 0.51 8.38 0.42 1.54e-15 Prostate cancer (SNP x SNP interaction); CRC cis rs897984 0.609 rs11862744 chr16:31057800 G/A cg00531865 chr16:30841666 NA -0.44 -6.28 -0.33 1.05e-9 Dementia with Lewy bodies; CRC cis rs66569888 0.789 rs1317569 chr2:106735490 C/A cg15412446 chr2:106886593 NA -0.5 -6.97 -0.36 1.7e-11 Facial morphology (factor 23); CRC cis rs79349575 0.783 rs62078370 chr17:47026836 G/C cg22482690 chr17:47019901 SNF8 0.49 8.19 0.41 5.85e-15 Type 2 diabetes; CRC cis rs9916302 0.904 rs8068427 chr17:37511517 G/A cg15445000 chr17:37608096 MED1 -0.42 -9.05 -0.45 1.25e-17 Glomerular filtration rate (creatinine); CRC cis rs1707322 0.963 rs6690652 chr1:46376692 G/T cg03146154 chr1:46216737 IPP 0.51 7.16 0.37 5.32e-12 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg20227976 chr9:35757314 NA 0.45 6.85 0.35 3.59e-11 Intelligence (multi-trait analysis); CRC cis rs2361718 0.603 rs12951255 chr17:78085597 A/G cg27427491 chr17:78079615 GAA -0.44 -7.01 -0.36 1.4e-11 Yeast infection; CRC cis rs2760061 0.626 rs1636192 chr1:228124688 A/G cg02753203 chr1:228287806 NA -0.67 -10.1 -0.49 4.48e-21 Diastolic blood pressure; CRC cis rs911119 0.908 rs12624424 chr20:23601878 C/T cg16589663 chr20:23618590 CST3 0.57 7.3 0.37 2.16e-12 Chronic kidney disease; CRC cis rs6429082 0.967 rs704709 chr1:235620964 C/T cg26050004 chr1:235667680 B3GALNT2 0.44 6.56 0.34 2.14e-10 Adiposity; CRC cis rs6502050 0.871 rs62079994 chr17:80076516 T/C cg11859384 chr17:80120422 CCDC57 0.37 5.82 0.31 1.43e-8 Life satisfaction; CRC cis rs2708977 0.901 rs3731938 chr2:97166204 A/G cg01950434 chr2:97203154 ARID5A -0.43 -6.4 -0.33 5.2e-10 Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes; CRC cis rs6952808 0.500 rs3800902 chr7:2144378 C/T cg21782813 chr7:2030301 MAD1L1 0.54 9.52 0.46 3.92e-19 Bipolar disorder and schizophrenia; CRC cis rs3733585 0.664 rs28602527 chr4:9958327 G/A cg00071950 chr4:10020882 SLC2A9 -0.54 -9.65 -0.47 1.42e-19 Cleft plate (environmental tobacco smoke interaction); CRC cis rs6952808 0.510 rs13227554 chr7:2048220 G/C cg04267008 chr7:1944627 MAD1L1 0.6 8.73 0.43 1.35e-16 Bipolar disorder and schizophrenia; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg01956147 chr2:17935879 GEN1;SMC6 0.36 6.04 0.32 4.15e-9 Liver disease severity in Alagille syndrome; CRC cis rs7705042 0.865 rs249641 chr5:141525305 A/G cg07392085 chr5:141489673 NDFIP1 0.45 7.25 0.37 2.94e-12 Asthma; CRC cis rs10504229 0.683 rs73603874 chr8:58108340 G/A cg02290350 chr8:58132656 NA -0.59 -8.03 -0.4 1.7e-14 Developmental language disorder (linguistic errors); CRC cis rs6921919 0.638 rs2108926 chr6:28308747 A/T cg15845792 chr6:28175446 NA 0.49 6.58 0.34 1.88e-10 Autism spectrum disorder or schizophrenia; CRC cis rs2227564 0.700 rs12413039 chr10:75524759 C/G cg00564723 chr10:75632066 CAMK2G 0.31 7.09 0.36 8.28e-12 Crohn's disease;Inflammatory bowel disease; CRC trans rs983332 0.512 rs17130136 chr1:88213827 A/C cg09221037 chr5:1523205 LPCAT1 0.63 6.12 0.32 2.65e-9 Response to TNF antagonist treatment; CRC cis rs4862750 0.832 rs6836426 chr4:187897837 T/G cg07414643 chr4:187882934 NA 0.37 6.4 0.33 5.31e-10 Lobe attachment (rater-scored or self-reported); CRC cis rs17270561 0.887 rs9358870 chr6:25719210 T/C cg17691542 chr6:26056736 HIST1H1C 0.68 7.59 0.39 3.38e-13 Iron status biomarkers; CRC cis rs216303 1.000 rs216294 chr12:6153750 A/G cg19878637 chr12:6148451 VWF -0.6 -6.47 -0.34 3.58e-10 Low vWF levels; CRC cis rs3820068 0.581 rs61056912 chr1:15926296 A/G cg27534772 chr1:16042836 PLEKHM2 0.55 10.95 0.52 5.37e-24 Systolic blood pressure; CRC cis rs4332037 0.906 rs62442903 chr7:1953416 G/A cg23422044 chr7:1970798 MAD1L1 -0.6 -7.27 -0.37 2.58e-12 Bipolar disorder; CRC cis rs6500602 0.727 rs10451135 chr16:4580214 T/C cg08645402 chr16:4508243 NA 0.63 10.91 0.52 7.24e-24 Schizophrenia; CRC cis rs7662987 0.517 rs2851265 chr4:100029684 A/G cg13256891 chr4:100009986 ADH5 0.63 8.4 0.42 1.4e-15 Smoking initiation; CRC cis rs3820068 0.705 rs72645804 chr1:15868387 A/C cg27534772 chr1:16042836 PLEKHM2 0.42 6.95 0.36 2.02e-11 Systolic blood pressure; CRC cis rs9733 0.519 rs6700022 chr1:150670484 G/T cg18016565 chr1:150552671 MCL1 -0.45 -6.73 -0.35 7.71e-11 Tonsillectomy; CRC cis rs7208859 0.725 rs9897673 chr17:29243366 T/C cg14008862 chr17:28927542 LRRC37B2 0.49 6.1 0.32 2.96e-9 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs9814567 1.000 rs9832785 chr3:134213070 A/G cg06541857 chr3:134203789 ANAPC13;CEP63 -0.4 -6.01 -0.31 4.88e-9 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs7917772 0.636 rs2250580 chr10:104505687 C/G cg04362960 chr10:104952993 NT5C2 -0.49 -6.19 -0.32 1.81e-9 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC cis rs9463078 0.665 rs4714816 chr6:44715168 T/C cg25276700 chr6:44698697 NA 0.31 7.57 0.38 3.91e-13 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; CRC cis rs9649213 0.593 rs1468338 chr7:97951118 T/C cg08684580 chr7:98029266 BAIAP2L1 -0.31 -5.62 -0.3 4.03e-8 Prostate cancer (SNP x SNP interaction); CRC cis rs995000 0.931 rs7548877 chr1:63005950 T/C cg19896129 chr1:63156450 NA -0.45 -7.04 -0.36 1.15e-11 Triglyceride levels; CRC cis rs4638749 0.677 rs1563112 chr2:108850579 C/T cg25838818 chr2:108905173 SULT1C2 -0.37 -6.21 -0.32 1.6e-9 Blood pressure; CRC cis rs9487051 0.714 rs7757347 chr6:109633815 G/A cg01475377 chr6:109611718 NA -0.36 -6.33 -0.33 8.18e-10 Reticulocyte fraction of red cells; CRC cis rs12745968 0.587 rs1034218 chr1:93049131 A/G cg17283838 chr1:93427260 FAM69A -0.45 -6.17 -0.32 2.06e-9 Bipolar disorder and schizophrenia; CRC cis rs2836974 0.584 rs7276774 chr21:40628725 T/G cg11644478 chr21:40555479 PSMG1 -0.71 -11.66 -0.54 1.6e-26 Cognitive function; CRC cis rs9467711 0.606 rs9358939 chr6:26416787 C/G cg16898833 chr6:26189333 HIST1H4D 0.89 7.28 0.37 2.4e-12 Autism spectrum disorder or schizophrenia; CRC cis rs9488822 0.636 rs7745074 chr6:116347432 G/A cg15226275 chr6:116381976 FRK 0.29 8.15 0.41 7.73e-15 Cholesterol, total;LDL cholesterol; CRC cis rs13217239 0.574 rs9366680 chr6:27006123 A/T cg18867708 chr6:26865862 GUSBL1 0.38 5.78 0.3 1.69e-8 Schizophrenia; CRC cis rs6893300 0.560 rs1019443 chr5:179207547 A/G cg14593053 chr5:179126677 CANX -0.51 -8.15 -0.41 7.69e-15 Resting heart rate; CRC trans rs7302981 0.667 rs7136648 chr12:50624822 A/G cg00474734 chr12:53645975 MFSD5 -0.38 -6.04 -0.32 4.17e-9 Systolic blood pressure; CRC cis rs7918232 0.882 rs10829190 chr10:27409555 C/T cg14240646 chr10:27532245 ACBD5 -0.86 -10.18 -0.49 2.47e-21 Breast cancer; CRC cis rs1997103 0.954 rs6953004 chr7:55411919 G/A cg17469321 chr7:55412551 NA 0.72 11.16 0.52 9.35e-25 QRS interval (sulfonylurea treatment interaction); CRC trans rs7618501 1.000 rs7648987 chr3:49868455 A/G cg21665057 chr3:196295764 WDR53;FBXO45 0.82 15.05 0.64 2.65e-39 Intelligence (multi-trait analysis); CRC cis rs2424590 1.000 rs2424590 chr20:23636980 C/T cg16589663 chr20:23618590 CST3 -0.54 -6.72 -0.35 7.93e-11 Blood protein levels; CRC cis rs208520 0.909 rs9354411 chr6:67019930 A/G cg07460842 chr6:66804631 NA 0.84 9.91 0.48 1.91e-20 Exhaled nitric oxide output; CRC cis rs4713118 0.868 rs7756968 chr6:27734954 C/G cg15845792 chr6:28175446 NA 0.7 7.6 0.39 3.02e-13 Parkinson's disease; CRC cis rs1568889 0.938 rs6484358 chr11:28260364 A/T cg06544937 chr11:28130018 METT5D1;KIF18A 0.8 11.51 0.54 5.29e-26 Bipolar disorder; CRC cis rs9322817 0.691 rs2486135 chr6:105282263 C/T cg02098413 chr6:105308735 HACE1 0.44 8.72 0.43 1.41e-16 Thyroid stimulating hormone; CRC cis rs2549003 1.000 rs6873426 chr5:131818631 G/T cg02551604 chr5:131831745 NA -0.54 -8.36 -0.42 1.76e-15 Asthma (sex interaction); CRC cis rs4253772 0.591 rs6008538 chr22:46685963 G/A cg03482458 chr22:46692211 CN5H6.4;GTSE1 0.58 8.31 0.42 2.51e-15 LDL cholesterol;Cholesterol, total; CRC trans rs2228479 0.867 rs62052189 chr16:89975555 G/C cg24644049 chr4:85504048 CDS1 0.74 7.25 0.37 2.95e-12 Skin colour saturation; CRC cis rs6540559 0.673 rs17015224 chr1:209968918 G/A cg21951975 chr1:209979733 IRF6 0.49 6.55 0.34 2.24e-10 Cleft lip with or without cleft palate; CRC cis rs2976388 0.609 rs2717601 chr8:143807924 T/C cg20041105 chr8:143859282 LYNX1 0.47 8.27 0.41 3.43e-15 Urinary tract infection frequency; CRC cis rs11105298 0.786 rs10858897 chr12:89922032 C/A cg08166232 chr12:89918718 WDR51B;GALNT4 -0.62 -7.92 -0.4 3.73e-14 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; CRC cis rs75804782 0.625 rs11889723 chr2:239471469 A/G cg21861151 chr2:239478365 NA -0.46 -6.23 -0.32 1.44e-9 Morning vs. evening chronotype;Chronotype; CRC cis rs2180341 1.000 rs9385419 chr6:127597591 A/G cg24812749 chr6:127587940 RNF146 0.94 13.67 0.6 5.36e-34 Breast cancer; CRC cis rs6066835 0.572 rs6066809 chr20:47273119 T/C cg18078177 chr20:47281410 PREX1 0.8 6.04 0.32 4.22e-9 Multiple myeloma; CRC cis rs7580658 0.929 rs4662575 chr2:128022215 C/T cg09760422 chr2:128146352 NA -0.37 -7.24 -0.37 3.17e-12 Protein C levels; CRC cis rs17401966 0.931 rs17034821 chr1:10414645 A/G cg19773385 chr1:10388646 KIF1B -0.68 -11.03 -0.52 2.77e-24 Hepatocellular carcinoma; CRC cis rs875971 0.522 rs2008188 chr7:65429013 G/C cg18876405 chr7:65276391 NA 0.66 12.14 0.56 2.9e-28 Aortic root size; CRC cis rs4700695 0.764 rs37018 chr5:65366645 A/G cg21114390 chr5:65439923 SFRS12 0.56 6.6 0.34 1.63e-10 Facial morphology (factor 19); CRC cis rs6912958 0.781 rs2207146 chr6:88180641 A/G cg12350822 chr6:88032061 C6orf162;GJB7 -0.31 -5.77 -0.3 1.8e-8 Monocyte percentage of white cells; CRC cis rs910316 0.737 rs175424 chr14:75626257 T/C cg11812906 chr14:75593930 NEK9 -0.56 -8.54 -0.43 4.98e-16 Height; CRC cis rs7945705 0.935 rs11042103 chr11:8888700 C/T cg12365402 chr11:9010492 NRIP3 0.47 7.5 0.38 6.18e-13 Hemoglobin concentration; CRC cis rs9311474 0.629 rs4282054 chr3:52566065 T/C cg13284614 chr3:52569169 NT5DC2;LOC440957 0.36 5.98 0.31 5.78e-9 Electroencephalogram traits; CRC cis rs9329221 0.905 rs4433149 chr8:10249268 A/T cg27411982 chr8:10470053 RP1L1 -0.36 -5.86 -0.31 1.14e-8 Neuroticism; CRC cis rs1552244 0.751 rs12715665 chr3:10021601 C/T cg00166722 chr3:10149974 C3orf24 0.57 7.76 0.39 1.1e-13 Alzheimer's disease; CRC trans rs1005277 0.579 rs2505240 chr10:38442419 G/T cg17830980 chr10:43048298 ZNF37B -0.59 -9.89 -0.48 2.25e-20 Extrinsic epigenetic age acceleration; CRC cis rs7517126 1.000 rs35445694 chr1:196838865 A/T cg13682187 chr1:196946512 CFHR5 -0.4 -6.26 -0.33 1.17e-9 Blood protein levels; CRC cis rs2860975 1.000 rs11188133 chr10:96772015 G/A cg09036531 chr10:96991505 NA -0.44 -5.85 -0.31 1.18e-8 Immune response to smallpox vaccine (IL-6); CRC cis rs4285028 0.948 rs79103597 chr3:121667629 C/T cg11130432 chr3:121712080 ILDR1 -0.51 -6.64 -0.34 1.28e-10 Multiple sclerosis; CRC cis rs7618501 0.501 rs35275715 chr3:49959148 A/G cg24110177 chr3:50126178 RBM5 -0.6 -9.31 -0.46 1.85e-18 Intelligence (multi-trait analysis); CRC cis rs449789 0.857 rs9346784 chr6:159703757 G/T cg14500486 chr6:159655392 FNDC1 -0.48 -7.37 -0.38 1.36e-12 Pulse pressure; CRC cis rs6912958 0.703 rs9362427 chr6:88097634 G/T cg04972856 chr6:88032051 C6orf162;GJB7 0.33 6.07 0.32 3.5e-9 Monocyte percentage of white cells; CRC cis rs8016982 0.589 rs4640110 chr14:81692191 A/G cg01989461 chr14:81687754 GTF2A1 -0.43 -5.68 -0.3 2.97e-8 Schizophrenia; CRC trans rs11098499 0.954 rs17046116 chr4:120387259 G/A cg25214090 chr10:38739885 LOC399744 0.66 10.55 0.5 1.36e-22 Corneal astigmatism; CRC cis rs9948 0.655 rs62156228 chr2:97420335 A/G cg20312557 chr2:97357134 FER1L5 -0.6 -5.6 -0.3 4.5e-8 Erectile dysfunction and prostate cancer treatment; CRC cis rs7043114 0.507 rs2007837 chr9:95189767 A/T cg14631576 chr9:95140430 CENPP -0.31 -5.89 -0.31 9.31e-9 Height; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg02712401 chr12:6961946 USP5;CDCA3 0.45 6.26 0.33 1.17e-9 Response to antipsychotic treatment; CRC cis rs7192380 0.737 rs7204433 chr16:69589924 A/G cg00738113 chr16:70207722 CLEC18C -0.33 -5.81 -0.3 1.5e-8 Sjögren's syndrome; CRC cis rs3106136 0.609 rs11097406 chr4:95146042 C/T cg11021082 chr4:95130006 SMARCAD1 -0.47 -6.74 -0.35 6.98e-11 Capecitabine sensitivity; CRC cis rs13108904 0.870 rs1564508 chr4:1244879 A/G cg20887711 chr4:1340912 KIAA1530 0.39 5.68 0.3 2.91e-8 Obesity-related traits; CRC cis rs889312 0.500 rs11960484 chr5:56109154 C/T cg12311346 chr5:56204834 C5orf35 0.45 6.92 0.36 2.43e-11 Breast cancer;Breast cancer (early onset); CRC cis rs2346177 0.542 rs13024414 chr2:46687062 G/A cg26688816 chr2:46740690 ATP6V1E2 -0.61 -9.18 -0.45 4.84e-18 HDL cholesterol; CRC cis rs9916302 0.904 rs801420 chr17:37466103 C/G cg07936489 chr17:37558343 FBXL20 0.82 12.72 0.57 2.08e-30 Glomerular filtration rate (creatinine); CRC cis rs2204008 0.665 rs11179830 chr12:38220966 T/C cg26384229 chr12:38710491 ALG10B 0.64 8.86 0.44 5.07e-17 Bladder cancer; CRC cis rs17270561 0.609 rs4712965 chr6:25742022 G/T cg16482183 chr6:26056742 HIST1H1C 0.83 10.69 0.51 4.46e-23 Iron status biomarkers; CRC cis rs1865760 0.713 rs2013063 chr6:25994098 C/T cg18357526 chr6:26021779 HIST1H4A 0.39 5.6 0.3 4.47e-8 Height; CRC trans rs12599106 0.792 rs12597352 chr16:34638507 A/T cg21548813 chr6:291882 DUSP22 -0.51 -7.11 -0.36 7.24e-12 Menopause (age at onset); CRC cis rs12134245 0.747 rs11164929 chr1:92012836 G/C cg25838465 chr1:92012736 NA -0.71 -13.47 -0.6 2.98e-33 Breast cancer; CRC cis rs7904368 0.754 rs12253908 chr10:16853358 T/C cg14835575 chr10:16859367 RSU1 0.46 6.01 0.31 4.83e-9 Ratio of the peak velocity of the mitral E-Wave divided by the peak velocity of the mitral A-wave.; CRC cis rs2019137 0.901 rs4849176 chr2:113977936 C/T cg19083407 chr2:113993142 PAX8;LOC440839;LOC654433 -0.45 -6.44 -0.33 4.13e-10 Lymphocyte counts; CRC cis rs13256369 0.951 rs13259955 chr8:8565885 C/G cg06636001 chr8:8085503 FLJ10661 0.46 5.91 0.31 8.32e-9 Obesity-related traits; CRC cis rs477895 0.653 rs66648159 chr11:63899429 G/A cg18225595 chr11:63971243 STIP1 0.57 7.54 0.38 4.59e-13 Mean platelet volume; CRC cis rs9905704 0.831 rs12939500 chr17:56848677 T/C cg12560992 chr17:57184187 TRIM37 0.52 7.25 0.37 2.94e-12 Testicular germ cell tumor; CRC cis rs8072100 0.748 rs9912592 chr17:45556945 G/A cg25173405 chr17:45401733 C17orf57 -0.44 -6.71 -0.35 8.58e-11 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs10504229 0.595 rs79077737 chr8:58117520 G/A cg24829409 chr8:58192753 C8orf71 -0.55 -7.85 -0.4 6.01e-14 Developmental language disorder (linguistic errors); CRC cis rs4689388 0.926 rs5018647 chr4:6292799 A/C cg25554036 chr4:6271136 WFS1 0.53 8.7 0.43 1.61e-16 Type 2 diabetes and other traits;Type 2 diabetes; CRC cis rs12580194 0.593 rs61957924 chr12:55744100 T/C cg19537932 chr12:55886519 OR6C68 -0.66 -8.57 -0.43 4.1e-16 Cancer; CRC cis rs798554 0.959 rs798557 chr7:2758982 G/A cg13628971 chr7:2884303 GNA12 0.48 6.41 0.33 5e-10 Height; CRC cis rs10751667 1.000 rs4074232 chr11:977682 C/G cg01483505 chr11:975446 AP2A2 0.41 6.29 0.33 1.03e-9 Alzheimer's disease (late onset); CRC trans rs8097070 0.661 rs9966711 chr18:23171413 C/G cg10330149 chr12:112820238 NA 0.53 5.97 0.31 6.24e-9 Systemic juvenile idiopathic arthritis; CRC cis rs5753618 0.561 rs737684 chr22:31659827 C/G cg07713946 chr22:31675144 LIMK2 -0.4 -5.75 -0.3 2e-8 Colorectal cancer; CRC cis rs72781680 0.898 rs72788212 chr2:24087385 G/A cg08917208 chr2:24149416 ATAD2B 0.92 9.37 0.46 1.23e-18 Lymphocyte counts; CRC cis rs910187 0.596 rs6066222 chr20:45801917 G/A cg27589058 chr20:45804311 EYA2 -0.44 -8.76 -0.44 1.02e-16 Migraine; CRC cis rs10540 1.000 rs35874808 chr11:506442 G/T cg03352830 chr11:487213 PTDSS2 0.66 7.53 0.38 4.88e-13 Body mass index; CRC cis rs9894429 0.621 rs7502337 chr17:79588470 T/C cg21984481 chr17:79567631 NPLOC4 -0.44 -7.6 -0.39 3.13e-13 Eye color traits; CRC cis rs10256972 0.732 rs12701856 chr7:1107707 C/T cg23978390 chr7:1156363 C7orf50 0.42 5.64 0.3 3.6e-8 Longevity;Endometriosis; CRC cis rs10760158 0.800 rs4837829 chr9:124045958 T/C cg14417974 chr9:124058376 GSN -0.33 -5.63 -0.3 3.83e-8 Pulse pressure; CRC cis rs4132509 1.000 rs6675851 chr1:243787494 G/A cg21452805 chr1:244014465 NA 0.46 6.15 0.32 2.27e-9 RR interval (heart rate); CRC cis rs2354432 0.546 rs7539416 chr1:146881586 C/T cg25205988 chr1:146714368 CHD1L 0.94 10.19 0.49 2.23e-21 Mitochondrial DNA levels; CRC cis rs7412746 0.658 rs11204739 chr1:150865760 A/G cg18016565 chr1:150552671 MCL1 0.42 5.94 0.31 7.1e-9 Melanoma; CRC cis rs1707322 0.963 rs4660900 chr1:46419605 T/C cg06784218 chr1:46089804 CCDC17 0.51 9.06 0.45 1.19e-17 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs2066819 1.000 rs76151170 chr12:56659320 C/T cg26714650 chr12:56694279 CS -1.38 -11.34 -0.53 2.14e-25 Psoriasis vulgaris; CRC cis rs4974559 0.739 rs28444605 chr4:1290281 C/A cg02980000 chr4:1222292 CTBP1 0.71 7.96 0.4 2.75e-14 Systolic blood pressure; CRC cis rs9467711 0.606 rs9379873 chr6:26402717 T/C cg12315302 chr6:26189340 HIST1H4D 0.8 6.29 0.33 1.02e-9 Autism spectrum disorder or schizophrenia; CRC cis rs7927771 1.000 rs12419692 chr11:47624714 A/C cg05585544 chr11:47624801 NA 0.61 11.2 0.53 7.1e-25 Subjective well-being; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg12531003 chr19:56152621 ZNF580 0.45 6.72 0.35 7.82e-11 Liver disease severity in Alagille syndrome; CRC cis rs3996993 0.809 rs3957357 chr6:52668687 A/G cg20803780 chr6:52668592 GSTA1 -0.38 -7.01 -0.36 1.38e-11 Hemoglobin concentration; CRC trans rs11098499 0.779 rs6815934 chr4:120267310 T/C cg25214090 chr10:38739885 LOC399744 0.53 8.51 0.42 6.36e-16 Corneal astigmatism; CRC cis rs6860806 0.507 rs272880 chr5:131670178 C/T cg18301423 chr5:131593218 PDLIM4 0.38 6.35 0.33 6.95e-10 Breast cancer; CRC cis rs4974559 0.501 rs1250093 chr4:1240911 G/A cg02980000 chr4:1222292 CTBP1 -0.73 -8.37 -0.42 1.72e-15 Systolic blood pressure; CRC cis rs7246967 0.611 rs16999598 chr19:22943125 A/G cg08271804 chr19:22816896 ZNF492 0.38 5.85 0.31 1.2e-8 Bronchopulmonary dysplasia; CRC cis rs13191362 1.000 rs34655790 chr6:163202739 G/A cg06582575 chr6:163149167 PACRG;PARK2 0.87 11.16 0.52 9.41e-25 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs1065852 0.526 rs2097562 chr22:42389500 T/C cg00645731 chr22:42541494 CYP2D7P1 0.4 6.86 0.35 3.42e-11 Response to serotonin reuptake inhibitors in major depressive disorder (plasma drug and metabolite levels); CRC cis rs10751667 0.577 rs7946461 chr11:974035 A/G ch.11.42038R chr11:967971 AP2A2 0.58 10.03 0.48 7.98e-21 Alzheimer's disease (late onset); CRC cis rs9715521 0.900 rs62299249 chr4:59824174 G/A cg11281224 chr4:60001000 NA -0.38 -5.63 -0.3 3.86e-8 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs2839186 0.587 rs35679325 chr21:47640980 A/G cg09417038 chr21:47716443 C21orf57 0.38 6.21 0.32 1.6e-9 Testicular germ cell tumor; CRC cis rs7589728 0.563 rs80324973 chr2:88447264 T/G cg04511125 chr2:88470314 THNSL2 0.82 8.7 0.43 1.59e-16 Plasma clusterin levels; CRC cis rs7811142 0.830 rs6975660 chr7:99975266 A/G cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.61 8.02 0.4 1.83e-14 Platelet count; CRC cis rs7927592 0.912 rs55767696 chr11:68375120 C/G cg16797656 chr11:68205561 LRP5 0.36 5.77 0.3 1.79e-8 Total body bone mineral density; CRC cis rs2032447 0.670 rs198852 chr6:26104448 A/G cg03264133 chr6:25882463 NA 0.43 5.89 0.31 9.41e-9 Intelligence (multi-trait analysis); CRC cis rs12048904 0.505 rs11166508 chr1:101233511 A/G cg16556008 chr1:101360663 SLC30A7;EXTL2 -0.81 -12.16 -0.56 2.29e-28 Multiple sclerosis; CRC trans rs72862334 0.684 rs72861062 chr2:146556359 C/A cg04759376 chr10:77190437 NA 0.59 5.96 0.31 6.43e-9 Coronary artery disease; CRC cis rs2839186 0.632 rs2839184 chr21:47689013 G/A cg09417038 chr21:47716443 C21orf57 -0.54 -8.69 -0.43 1.73e-16 Testicular germ cell tumor; CRC cis rs7677751 0.806 rs4864859 chr4:55090015 A/G cg13615338 chr4:55094005 PDGFRA 0.42 6.19 0.32 1.81e-9 Corneal astigmatism; CRC trans rs2303319 0.504 rs62187611 chr2:162431946 A/G cg18122310 chr12:50236657 BCDIN3D -0.75 -6.24 -0.33 1.33e-9 Cognitive function; CRC cis rs1707322 1.000 rs10890375 chr1:46406581 G/A cg06784218 chr1:46089804 CCDC17 0.51 9.07 0.45 1.11e-17 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs2239547 0.522 rs2336669 chr3:52994138 C/T cg18404041 chr3:52824283 ITIH1 0.38 7.02 0.36 1.3e-11 Schizophrenia; CRC cis rs67311347 0.544 rs2123998 chr3:40359005 C/G cg09455208 chr3:40491958 NA -0.32 -6.46 -0.34 3.77e-10 Renal cell carcinoma; CRC cis rs9467711 0.651 rs72834677 chr6:26106604 C/A cg19084075 chr6:26124329 HIST1H2AC;HIST1H2BC 0.69 5.66 0.3 3.36e-8 Autism spectrum disorder or schizophrenia; CRC cis rs6838801 1.000 rs6838801 chr4:77549559 G/T cg17476223 chr4:77663285 SHROOM3 0.41 5.63 0.3 3.93e-8 Cleft lip with or without cleft palate; CRC cis rs4664293 0.867 rs6432554 chr2:160579084 A/G cg08347373 chr2:160653686 CD302 -0.47 -7.43 -0.38 9.32e-13 Monocyte percentage of white cells; CRC cis rs2075371 0.863 rs34231360 chr7:133944988 A/C cg20476274 chr7:133979776 SLC35B4 0.72 12.05 0.55 5.88e-28 Mean platelet volume; CRC cis rs7909074 0.933 rs879073 chr10:45399882 C/G cg04218760 chr10:45406644 TMEM72 -0.34 -9.25 -0.45 2.91e-18 Mean corpuscular volume; CRC cis rs1401999 1.000 rs7620350 chr3:183710053 A/T cg05044414 chr3:183734942 ABCC5 0.48 8.31 0.42 2.56e-15 Anterior chamber depth; CRC cis rs12762955 0.677 rs11250267 chr10:1156487 A/G cg20503657 chr10:835505 NA 0.59 7.57 0.39 3.84e-13 Response to angiotensin II receptor blocker therapy; CRC cis rs7493 0.950 rs17879277 chr7:95030632 A/C cg01874867 chr7:94954059 PON1 -0.5 -6.33 -0.33 8.15e-10 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs2073300 0.609 rs6132610 chr20:23403987 C/T cg12062639 chr20:23401060 NAPB 0.84 7.64 0.39 2.34e-13 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs10504229 1.000 rs113379801 chr8:58173686 C/G cg22535103 chr8:58192502 C8orf71 -0.79 -12.09 -0.55 4.31e-28 Developmental language disorder (linguistic errors); CRC trans rs8002861 0.727 rs9525852 chr13:44405197 G/C cg17145862 chr1:211918768 LPGAT1 -0.5 -8.2 -0.41 5.35e-15 Leprosy; CRC cis rs10927875 0.722 rs945425 chr1:16348412 T/C cg24140574 chr1:16342155 HSPB7 0.44 5.8 0.3 1.57e-8 Dilated cardiomyopathy; CRC cis rs6912958 0.525 rs59322 chr6:88020521 C/A cg12350822 chr6:88032061 C6orf162;GJB7 0.46 9.15 0.45 6.02e-18 Monocyte percentage of white cells; CRC cis rs12348691 0.503 rs7024345 chr9:100595238 A/G cg13688889 chr9:100608707 NA -0.46 -5.82 -0.31 1.43e-8 Alopecia areata; CRC cis rs6840360 1.000 rs1366909 chr4:152588421 A/C cg09659197 chr4:152720779 NA 0.51 10.85 0.51 1.17e-23 Intelligence (multi-trait analysis); CRC cis rs7605827 0.930 rs11687702 chr2:15682857 T/C cg19274914 chr2:15703543 NA 0.39 5.82 0.31 1.4e-8 Educational attainment (years of education); CRC cis rs7618915 0.501 rs2164885 chr3:52731269 T/C cg11645453 chr3:52864694 ITIH4 0.36 6.5 0.34 3.01e-10 Bipolar disorder; CRC cis rs9814567 0.929 rs2241556 chr3:134183312 C/T cg06541857 chr3:134203789 ANAPC13;CEP63 0.41 6.01 0.31 4.89e-9 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs10078 0.515 rs1053299 chr5:470760 G/A cg07599136 chr5:415885 AHRR 0.68 6.74 0.35 7.29e-11 Fat distribution (HIV); CRC cis rs2204008 0.689 rs1581357 chr12:38391479 C/G cg26384229 chr12:38710491 ALG10B 0.7 9.7 0.47 9.68e-20 Bladder cancer; CRC cis rs7666738 0.716 rs9994641 chr4:99101605 C/T cg17366294 chr4:99064904 C4orf37 0.35 5.71 0.3 2.59e-8 Colonoscopy-negative controls vs population controls; CRC trans rs8073060 0.544 rs225287 chr17:33929487 G/T cg19694781 chr19:47549865 TMEM160 -1.02 -14.1 -0.61 1.25e-35 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; CRC cis rs8005677 1.000 rs1956880 chr14:23394007 A/G cg25600027 chr14:23388339 RBM23 -0.54 -8.4 -0.42 1.34e-15 Cognitive ability (multi-trait analysis); CRC cis rs10097731 0.901 rs4398860 chr8:82041753 C/T cg25230327 chr8:82042993 NA -0.94 -13.46 -0.6 3.4e-33 Serum total protein level; CRC cis rs4561483 0.767 rs33633 chr16:11994857 A/C cg08843971 chr16:11963173 GSPT1 -0.63 -9.72 -0.47 8.4e-20 Testicular germ cell tumor; CRC cis rs9467711 0.606 rs9366653 chr6:26354247 G/A cg16898833 chr6:26189333 HIST1H4D 0.75 6.46 0.34 3.82e-10 Autism spectrum disorder or schizophrenia; CRC cis rs6502050 0.835 rs28640920 chr17:80105151 A/T cg19223190 chr17:80058835 NA 0.4 6.36 0.33 6.88e-10 Life satisfaction; CRC cis rs7727544 0.735 rs272881 chr5:131669264 G/A cg11843238 chr5:131593191 PDLIM4 0.3 5.64 0.3 3.74e-8 Blood metabolite levels; CRC cis rs344364 0.511 rs1742464 chr16:1947335 A/G cg14074117 chr16:1909714 C16orf73 -0.4 -5.66 -0.3 3.37e-8 Glomerular filtration rate in chronic kidney disease; CRC cis rs3018066 0.867 rs13101612 chr4:107128360 A/G cg01869342 chr4:106983673 TBCK -0.36 -5.63 -0.3 3.76e-8 Cancer; CRC cis rs1055129 0.560 rs2666003 chr17:73942976 G/A cg08125733 chr17:73851984 WBP2 0.49 6.52 0.34 2.58e-10 White matter hyperintensity burden; CRC cis rs459482 1.000 rs464783 chr21:42796480 A/G cg16817229 chr21:42798199 MX1 -0.39 -5.63 -0.3 3.89e-8 IgG glycosylation; CRC cis rs853679 0.517 rs12332979 chr6:28141548 T/G cg25164649 chr6:28176230 NA 0.78 9.69 0.47 1.04e-19 Depression; CRC cis rs3008870 0.583 rs2031495 chr1:67421714 G/T cg11518657 chr1:67396239 MIER1 0.55 5.93 0.31 7.58e-9 Lymphocyte percentage of white cells; CRC cis rs6461049 0.800 rs2398706 chr7:2156338 A/T cg22963979 chr7:1858916 MAD1L1 -0.39 -5.76 -0.3 1.96e-8 Schizophrenia; CRC cis rs950776 0.684 rs11637635 chr15:78877150 A/G cg06917634 chr15:78832804 PSMA4 -0.57 -8.48 -0.42 7.87e-16 Sudden cardiac arrest; CRC cis rs2836950 0.501 rs2836985 chr21:40701169 A/G cg11644478 chr21:40555479 PSMG1 -0.44 -6.48 -0.34 3.34e-10 Menarche (age at onset); CRC cis rs477895 0.653 rs34089806 chr11:63887987 C/T cg05016508 chr11:63871570 FLRT1;MACROD1 0.53 6.81 0.35 4.57e-11 Mean platelet volume; CRC trans rs2727020 0.573 rs7925419 chr11:49231859 C/T cg15704280 chr7:45808275 SEPT13 -0.65 -9.96 -0.48 1.35e-20 Coronary artery disease; CRC cis rs9547692 0.938 rs12020196 chr13:37469191 G/C cg01493522 chr13:37497338 NA -0.52 -7.16 -0.37 5.21e-12 Coronary artery disease; CRC cis rs899997 1.000 rs11629824 chr15:79005524 T/G cg22753661 chr15:79092743 ADAMTS7 0.43 5.9 0.31 9.09e-9 Coronary artery disease or large artery stroke; CRC cis rs10540 1.000 rs78520676 chr11:517173 G/A cg19913688 chr11:428466 ANO9 -0.68 -7.0 -0.36 1.44e-11 Body mass index; CRC cis rs13191362 0.935 rs35942036 chr6:163163297 C/T cg21926612 chr6:163149169 PACRG;PARK2 0.98 12.85 0.58 6.71e-31 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs9814567 0.806 rs4245903 chr3:134317074 C/T cg06109529 chr3:134205091 CEP63;ANAPC13 -0.68 -10.3 -0.49 9.43e-22 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg22038928 chr6:166756117 SFT2D1 0.4 6.27 0.33 1.12e-9 Liver disease severity in Alagille syndrome; CRC cis rs10504229 1.000 rs66840104 chr8:58190001 C/T cg22535103 chr8:58192502 C8orf71 -0.82 -12.27 -0.56 9.63e-29 Developmental language disorder (linguistic errors); CRC cis rs853679 0.506 rs1150693 chr6:28174590 T/C cg06470822 chr6:28175283 NA 0.96 13.78 0.6 2.07e-34 Depression; CRC cis rs6456156 0.774 rs6930998 chr6:167526940 A/C cg05540913 chr6:167530185 CCR6 -0.41 -7.4 -0.38 1.18e-12 Primary biliary cholangitis; CRC cis rs270601 0.721 rs270621 chr5:131605821 C/A cg11843238 chr5:131593191 PDLIM4 0.51 8.91 0.44 3.46e-17 Acylcarnitine levels; CRC cis rs6988636 1.000 rs6988636 chr8:124185970 A/G cg27053337 chr8:124217698 FAM83A 0.47 6.97 0.36 1.78e-11 Urinary uromodulin levels; CRC trans rs10983614 1.000 rs7867776 chr9:120072627 A/G cg17958798 chr17:7200008 NA 0.45 6.26 0.33 1.21e-9 Survival in pancreatic cancer; CRC cis rs9292777 0.777 rs1992662 chr5:40393852 A/G cg09067459 chr5:40385259 NA -0.57 -9.39 -0.46 1.01e-18 Crohn's disease;Multiple sclerosis; CRC cis rs4665809 0.590 rs7606351 chr2:26292545 A/C cg26119090 chr2:26468346 HADHA;HADHB -0.67 -8.22 -0.41 4.63e-15 Gut microbiome composition (summer); CRC cis rs7584330 0.780 rs937395 chr2:238378749 T/C cg14458575 chr2:238380390 NA 0.65 12.05 0.55 5.91e-28 Prostate cancer; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg03403966 chr4:85504051 CDS1 0.43 6.05 0.32 3.99e-9 Anxiety disorder; CRC cis rs6860806 0.661 rs334902 chr5:131586559 C/G cg22638593 chr5:131593259 PDLIM4 0.41 7.61 0.39 2.95e-13 Breast cancer; CRC trans rs2228479 0.850 rs1800355 chr16:89813194 C/T cg24644049 chr4:85504048 CDS1 0.9 7.46 0.38 7.69e-13 Skin colour saturation; CRC trans rs8002861 0.870 rs12865116 chr13:44440441 C/G cg17145862 chr1:211918768 LPGAT1 -0.67 -12.37 -0.56 3.86e-29 Leprosy; CRC cis rs8078723 0.933 rs55846942 chr17:38164470 G/A cg17344932 chr17:38183730 MED24;SNORD124 -0.45 -6.98 -0.36 1.62e-11 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); CRC cis rs4713118 0.662 rs149948 chr6:27974817 C/G cg15845792 chr6:28175446 NA 0.79 11.66 0.54 1.55e-26 Parkinson's disease; CRC trans rs875971 0.660 rs2191268 chr7:66110224 C/T cg06370862 chr6:50680748 TFAP2D -0.42 -6.66 -0.34 1.12e-10 Aortic root size; CRC cis rs7493 1.000 rs2040993 chr7:95047300 T/A cg20119798 chr7:94954144 PON1 -0.49 -6.26 -0.33 1.21e-9 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs13064411 0.696 rs6438156 chr3:113206929 C/A cg18753928 chr3:113234510 CCDC52 -0.7 -10.68 -0.51 4.62e-23 Response to simvastatin treatment (PCSK9 protein level change); CRC cis rs1691799 0.899 rs1168325 chr12:66728234 C/G cg16791601 chr12:66731901 HELB -0.68 -11.53 -0.54 4.57e-26 White blood cell count (basophil); CRC cis rs6088580 0.634 rs4911419 chr20:32995873 G/A cg24642439 chr20:33292090 TP53INP2 -0.37 -6.31 -0.33 8.76e-10 Glomerular filtration rate (creatinine); CRC cis rs898097 0.544 rs6502022 chr17:80908652 C/T cg03160526 chr17:80928410 B3GNTL1 0.51 8.34 0.42 2.09e-15 Breast cancer; CRC cis rs7224685 0.648 rs12453576 chr17:3881293 C/T cg11204139 chr17:3907470 NA 0.47 5.69 0.3 2.8e-8 Type 2 diabetes; CRC cis rs780096 0.506 rs56076827 chr2:27676287 A/T cg12000995 chr2:27665139 KRTCAP3 -0.32 -6.37 -0.33 6.46e-10 Total body bone mineral density; CRC cis rs10924970 0.625 rs2789370 chr1:235503256 A/G cg09010748 chr1:235293032 TOMM20 -0.44 -6.14 -0.32 2.39e-9 Asthma; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg14496862 chr7:100888369 FIS1 0.4 6.11 0.32 2.85e-9 Intelligence (multi-trait analysis); CRC cis rs1448094 0.512 rs61930864 chr12:86246740 G/A cg18827107 chr12:86230957 RASSF9 -0.45 -7.47 -0.38 7.34e-13 Major depressive disorder; CRC cis rs7937682 0.632 rs11603779 chr11:111781047 A/C cg09085632 chr11:111637200 PPP2R1B 0.94 14.72 0.63 5.16e-38 Primary sclerosing cholangitis; CRC trans rs11098499 0.954 rs71629403 chr4:120372567 C/T cg25214090 chr10:38739885 LOC399744 0.66 10.45 0.5 2.84e-22 Corneal astigmatism; CRC cis rs11098499 0.913 rs11098496 chr4:120167466 C/G cg09307838 chr4:120376055 NA 0.61 9.28 0.46 2.3e-18 Corneal astigmatism; CRC cis rs992157 0.644 rs6741757 chr2:219182748 T/C cg04880052 chr2:219191631 PNKD 0.41 6.15 0.32 2.3e-9 Colorectal cancer; CRC trans rs10858396 0.957 rs7029858 chr9:138273821 C/T cg05258489 chr8:61593179 CHD7 0.5 6.35 0.33 7.17e-10 Attention deficit hyperactivity disorder; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg00215801 chr6:34855797 TAF11;ANKS1A 0.41 6.8 0.35 5.01e-11 Liver disease severity in Alagille syndrome; CRC trans rs2303319 0.504 rs56965753 chr2:162597251 A/G cg10272801 chr16:14013773 ERCC4 -0.68 -6.07 -0.32 3.49e-9 Cognitive function; CRC cis rs916888 0.821 rs199505 chr17:44859410 A/G cg17911788 chr17:44343683 NA 0.56 6.86 0.35 3.4e-11 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg15459742 chr9:111775564 CTNNAL1 0.48 6.92 0.36 2.39e-11 Response to antipsychotic treatment; CRC cis rs56283067 0.740 rs111810959 chr6:44709460 C/A cg18551225 chr6:44695536 NA -0.42 -6.07 -0.32 3.55e-9 Total body bone mineral density; CRC cis rs11167764 1.000 rs11167764 chr5:141479065 A/C cg23435118 chr5:141488016 NDFIP1 -0.46 -7.24 -0.37 3.19e-12 Crohn's disease; CRC cis rs875971 1.000 rs778699 chr7:65868290 G/A cg12463550 chr7:65579703 CRCP 0.48 6.96 0.36 1.89e-11 Aortic root size; CRC cis rs3026101 0.671 rs739767 chr17:5290681 A/C cg25236894 chr17:5323110 RPAIN;NUP88 0.42 6.84 0.35 3.98e-11 Body mass index; CRC cis rs9341808 0.718 rs3805920 chr6:80892745 T/C cg08355045 chr6:80787529 NA 0.43 6.95 0.36 1.94e-11 Sitting height ratio; CRC cis rs17401966 1.000 rs12755094 chr1:10305711 T/C cg19773385 chr1:10388646 KIF1B -0.53 -7.41 -0.38 1.04e-12 Hepatocellular carcinoma; CRC cis rs9488822 0.676 rs1338667 chr6:116323910 T/A cg18764771 chr6:116381957 FRK 0.25 7.0 0.36 1.42e-11 Cholesterol, total;LDL cholesterol; CRC cis rs7119 0.717 rs12911963 chr15:77807175 G/C cg27398640 chr15:77910606 LINGO1 -0.45 -7.78 -0.39 9.51e-14 Type 2 diabetes; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg08348959 chr3:10290087 TATDN2 0.4 6.21 0.32 1.63e-9 Intelligence (multi-trait analysis); CRC cis rs2976388 0.578 rs34956412 chr8:143822028 C/T cg15511327 chr8:143859410 LYNX1 -0.38 -6.0 -0.31 5.14e-9 Urinary tract infection frequency; CRC cis rs7772486 0.790 rs6924159 chr6:146267873 A/G cg13319975 chr6:146136371 FBXO30 0.44 6.62 0.34 1.49e-10 Lobe attachment (rater-scored or self-reported); CRC cis rs11098499 0.708 rs10005237 chr4:120237897 T/C cg24375607 chr4:120327624 NA 0.48 7.64 0.39 2.32e-13 Corneal astigmatism; CRC cis rs2832191 1.000 rs2832183 chr21:30482150 G/A cg08807101 chr21:30365312 RNF160 -0.61 -9.81 -0.48 4.3e-20 Dental caries; CRC cis rs1997103 0.954 rs940880 chr7:55392619 C/G cg17469321 chr7:55412551 NA 0.74 11.44 0.53 9.57e-26 QRS interval (sulfonylurea treatment interaction); CRC cis rs561341 1.000 rs55959993 chr17:30254771 C/G cg00745463 chr17:30367425 LRRC37B -0.88 -9.68 -0.47 1.14e-19 Hip circumference adjusted for BMI; CRC cis rs9611519 1.000 rs9611519 chr22:41613188 C/T cg06634786 chr22:41940651 POLR3H -0.44 -5.61 -0.3 4.24e-8 Neuroticism; CRC cis rs12410462 0.892 rs35341041 chr1:227653885 G/A cg04117972 chr1:227635322 NA 0.68 7.58 0.39 3.61e-13 Major depressive disorder; CRC cis rs1018836 0.828 rs4735236 chr8:91583909 A/G cg16814680 chr8:91681699 NA -0.63 -9.6 -0.47 2.13e-19 Ejection fraction in Tripanosoma cruzi seropositivity; CRC cis rs6604026 0.698 rs2492294 chr1:93346566 C/G cg17283838 chr1:93427260 FAM69A -0.44 -5.69 -0.3 2.76e-8 Multiple sclerosis; CRC cis rs2075371 0.933 rs2544182 chr7:133949793 C/T cg20476274 chr7:133979776 SLC35B4 0.75 13.22 0.59 2.72e-32 Mean platelet volume; CRC cis rs4665809 1.000 rs6729757 chr2:26285102 A/G cg25036284 chr2:26402008 FAM59B -0.46 -6.01 -0.31 4.86e-9 Gut microbiome composition (summer); CRC cis rs2153535 0.521 rs6939827 chr6:8461360 C/G cg07606381 chr6:8435919 SLC35B3 0.67 10.8 0.51 1.8e-23 Motion sickness; CRC cis rs4363385 0.588 rs11586559 chr1:153025714 G/A cg25856811 chr1:152973957 SPRR3 -0.23 -6.16 -0.32 2.09e-9 Inflammatory skin disease; CRC cis rs8103278 0.507 rs4802275 chr19:46260375 C/T cg11657440 chr19:46296263 DMWD 0.71 12.29 0.56 7.64e-29 Coronary artery disease; CRC cis rs4862750 0.872 rs4862748 chr4:187877388 C/T cg07414643 chr4:187882934 NA -0.43 -7.13 -0.37 6.45e-12 Lobe attachment (rater-scored or self-reported); CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg07211739 chr21:34914437 SON;GART 0.46 6.38 0.33 5.9e-10 Anxiety disorder; CRC cis rs9467711 0.591 rs9461222 chr6:25905111 G/A cg08501292 chr6:25962987 TRIM38 0.99 9.48 0.46 5.43e-19 Autism spectrum disorder or schizophrenia; CRC cis rs7223966 1.000 rs8069687 chr17:61883023 C/T cg05941027 chr17:61774174 LIMD2 -0.37 -6.49 -0.34 3.1e-10 Hip circumference adjusted for BMI;Body mass index; CRC cis rs863345 0.604 rs7549581 chr1:158489704 T/C cg12129480 chr1:158549410 OR10X1 -0.3 -6.25 -0.33 1.25e-9 Pneumococcal bacteremia; CRC cis rs10504229 0.815 rs55855654 chr8:58164299 T/G cg20607798 chr8:58055168 NA 0.48 5.87 0.31 1.08e-8 Developmental language disorder (linguistic errors); CRC cis rs6089584 0.888 rs6587283 chr20:60613727 A/C cg18761221 chr20:60518478 NA 0.46 7.44 0.38 9e-13 Body mass index; CRC cis rs8044868 0.530 rs7940 chr16:72146441 C/G cg06172871 chr16:72088244 HP 0.43 6.27 0.33 1.15e-9 Body mass index (change over time) in cancer or chronic obstructive pulmonary disease;Body mass index (change over time) in cancer; CRC cis rs2032447 0.802 rs199755 chr6:25990367 G/A cg17691542 chr6:26056736 HIST1H1C 0.41 5.64 0.3 3.63e-8 Intelligence (multi-trait analysis); CRC cis rs4363385 0.818 rs11205176 chr1:153002481 A/G cg25856811 chr1:152973957 SPRR3 -0.26 -7.16 -0.37 5.44e-12 Inflammatory skin disease; CRC cis rs1005277 0.579 rs2749612 chr10:38488610 G/A cg25427524 chr10:38739819 LOC399744 -0.77 -13.79 -0.61 1.94e-34 Extrinsic epigenetic age acceleration; CRC cis rs4555082 0.874 rs2816620 chr14:105732704 G/T cg18132624 chr14:105716052 BTBD6;BRF1 -0.5 -8.0 -0.4 2.13e-14 Mean platelet volume;Platelet distribution width; CRC cis rs4713118 0.869 rs7776351 chr6:27726731 A/G cg06470822 chr6:28175283 NA -0.74 -10.77 -0.51 2.23e-23 Parkinson's disease; CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg11190155 chr3:9975447 CRELD1 -0.55 -6.7 -0.35 9.25e-11 Diisocyanate-induced asthma; CRC cis rs2535633 0.631 rs6799185 chr3:53101580 C/T cg11645453 chr3:52864694 ITIH4 0.35 6.5 0.34 2.92e-10 Body mass index; CRC cis rs208520 0.690 rs4710311 chr6:66823223 C/T cg07460842 chr6:66804631 NA -1.04 -14.75 -0.63 3.79e-38 Exhaled nitric oxide output; CRC cis rs4629180 1.000 rs13031791 chr2:102108790 T/C cg01388757 chr2:102091195 RFX8 0.65 8.7 0.43 1.61e-16 Chronic rhinosinusitis with nasal polyps; CRC cis rs965469 0.947 rs56689368 chr20:3332921 G/A cg25506879 chr20:3388711 C20orf194 -0.39 -5.81 -0.31 1.44e-8 IFN-related cytopenia; CRC cis rs7666738 0.962 rs4699605 chr4:99064379 A/G cg17366294 chr4:99064904 C4orf37 0.47 7.49 0.38 6.54e-13 Colonoscopy-negative controls vs population controls; CRC cis rs7123876 0.830 rs57614870 chr11:72435983 A/G cg04827223 chr11:72435913 ARAP1 -0.54 -7.49 -0.38 6.31e-13 Body mass index; CRC cis rs3099143 1.000 rs2629034 chr15:77042240 G/A cg21673338 chr15:77095150 SCAPER -0.76 -8.02 -0.4 1.83e-14 Recalcitrant atopic dermatitis; CRC cis rs734999 0.588 rs745368 chr1:2524205 C/T cg18854424 chr1:2615690 NA 0.41 7.84 0.4 6.48e-14 Ulcerative colitis; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg18202627 chr2:200776533 C2orf69 0.47 6.45 0.34 3.95e-10 Response to antipsychotic treatment; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg04971341 chr1:52607910 ZFYVE9 0.45 6.42 0.33 4.64e-10 Intelligence (multi-trait analysis); CRC cis rs4930103 0.619 rs10769945 chr11:1985127 C/T cg23202291 chr11:1979235 NA 0.63 9.41 0.46 9.14e-19 DNA methylation (parent-of-origin);DNA methylation (variation); CRC cis rs4975616 0.773 rs414965 chr5:1324121 G/A cg06550200 chr5:1325588 CLPTM1L -0.69 -11.09 -0.52 1.72e-24 Lung cancer; CRC cis rs4243830 0.850 rs10779787 chr1:6599755 C/G cg22792644 chr1:6614718 TAS1R1;NOL9 -0.69 -7.76 -0.39 1.08e-13 Body mass index; CRC cis rs11155671 0.530 rs9968871 chr6:150209196 G/A cg13206674 chr6:150067644 NUP43 0.51 6.81 0.35 4.79e-11 Testicular germ cell tumor; CRC cis rs5769765 1.000 rs1033665 chr22:50252127 A/G cg08270630 chr22:50330655 NA -0.41 -6.29 -0.33 1.03e-9 Schizophrenia; CRC cis rs2019137 0.936 rs3811059 chr2:113962071 C/T cg11763394 chr2:113992921 PAX8;LOC440839;LOC654433 -0.51 -7.23 -0.37 3.32e-12 Lymphocyte counts; CRC cis rs10751667 0.666 rs10902241 chr11:949129 G/A cg23136738 chr11:925521 AP2A2 -0.41 -7.01 -0.36 1.32e-11 Alzheimer's disease (late onset); CRC cis rs3733585 0.699 rs6815001 chr4:9958662 G/C cg00071950 chr4:10020882 SLC2A9 -0.54 -9.65 -0.47 1.42e-19 Cleft plate (environmental tobacco smoke interaction); CRC cis rs6952808 0.564 rs55865401 chr7:2145720 G/C cg04267008 chr7:1944627 MAD1L1 -0.64 -8.99 -0.44 2.02e-17 Bipolar disorder and schizophrenia; CRC cis rs561341 0.609 rs11658984 chr17:30186612 C/T cg13647721 chr17:30228624 UTP6 -0.63 -7.19 -0.37 4.38e-12 Hip circumference adjusted for BMI; CRC cis rs7197653 0.667 rs7190070 chr16:68353983 C/T cg05110241 chr16:68378359 PRMT7 -0.71 -7.34 -0.37 1.74e-12 Magnesium levels; CRC cis rs12580194 0.593 rs73326725 chr12:55749222 G/C cg19537932 chr12:55886519 OR6C68 -0.72 -9.1 -0.45 9.11e-18 Cancer; CRC cis rs1799949 1.000 rs1973646 chr17:41310495 T/C cg01879757 chr17:41196368 BRCA1 -0.41 -6.09 -0.32 3.08e-9 Menopause (age at onset); CRC cis rs4654899 0.865 rs10916910 chr1:21283192 G/T cg02927042 chr1:21476669 EIF4G3 -0.49 -7.55 -0.38 4.26e-13 Superior frontal gyrus grey matter volume; CRC cis rs7814319 0.840 rs10504961 chr8:97240129 C/T cg20787634 chr8:97240163 UQCRB -0.54 -9.39 -0.46 1.05e-18 Lung function (FVC); CRC cis rs523522 0.962 rs670568 chr12:121021206 C/T cg27279351 chr12:120934652 DYNLL1 0.75 10.75 0.51 2.64e-23 High light scatter reticulocyte count; CRC trans rs853679 0.607 rs33932084 chr6:28268824 A/G cg01620082 chr3:125678407 NA -0.85 -6.73 -0.35 7.41e-11 Depression; CRC cis rs35110281 0.782 rs7282933 chr21:45046988 A/G cg01579765 chr21:45077557 HSF2BP -0.38 -7.37 -0.38 1.41e-12 Mean corpuscular volume; CRC cis rs7959452 0.532 rs2291005 chr12:69764388 A/G cg14784868 chr12:69753453 YEATS4 0.85 15.01 0.64 3.63e-39 Blood protein levels; CRC cis rs1552244 1.000 rs7615764 chr3:10082592 C/T cg18598329 chr3:10140678 FANCD2;C3orf24 -0.89 -11.87 -0.55 2.69e-27 Alzheimer's disease; CRC cis rs2257205 0.667 rs8081074 chr17:56836596 G/A cg25885038 chr17:56607967 SEPT4 -0.53 -5.75 -0.3 2.07e-8 Pancreatic cancer; CRC cis rs2032447 0.714 rs199725 chr6:25953684 A/G cg03517284 chr6:25882590 NA -0.47 -6.55 -0.34 2.21e-10 Intelligence (multi-trait analysis); CRC cis rs2019137 0.836 rs4848318 chr2:113953952 T/C cg21550016 chr2:113992930 PAX8;LOC440839;LOC654433 -0.52 -7.42 -0.38 1e-12 Lymphocyte counts; CRC cis rs9549367 0.789 rs2025247 chr13:113882564 C/G cg18105134 chr13:113819100 PROZ -0.72 -10.82 -0.51 1.47e-23 Platelet distribution width; CRC cis rs10068717 1 rs10068717 chr5:141494934 C/T cg08523384 chr5:141488047 NDFIP1 -0.33 -5.88 -0.31 9.9e-9 Allergic disease (asthma, hay fever or eczema); CRC trans rs12599106 0.792 rs12597352 chr16:34638507 A/T cg18110333 chr6:292329 DUSP22 -0.57 -8.37 -0.42 1.68e-15 Menopause (age at onset); CRC trans rs2976388 0.609 rs2376491 chr8:143790934 G/A cg24628676 chr5:59189846 PDE4D -0.3 -6.05 -0.32 4.05e-9 Urinary tract infection frequency; CRC cis rs728616 0.510 rs17679603 chr10:82181434 C/T cg05935833 chr10:81318306 SFTPA2 -0.56 -6.44 -0.33 4.24e-10 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs2386661 0.547 rs11259742 chr10:5647078 C/T cg17085576 chr10:5658249 NA -0.42 -6.12 -0.32 2.71e-9 Breast cancer; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg02794174 chr8:61564980 NA 0.43 6.61 0.34 1.57e-10 Liver disease severity in Alagille syndrome; CRC cis rs4555082 0.834 rs2735817 chr14:105717796 A/G cg09237515 chr14:105715926 BTBD6;BRF1 0.38 5.83 0.31 1.31e-8 Mean platelet volume;Platelet distribution width; CRC cis rs6714710 0.603 rs12104810 chr2:98443658 C/T cg26665480 chr2:98280029 ACTR1B 0.52 7.18 0.37 4.53e-12 Posterior cortical atrophy and Alzheimer's disease; CRC cis rs2786111 0.898 rs1764792 chr1:197281941 A/G cg13682187 chr1:196946512 CFHR5 0.29 5.71 0.3 2.51e-8 Lupus nephritis in systemic lupus erythematosus; CRC cis rs853679 0.527 rs213228 chr6:28331252 A/C cg21251018 chr6:28226885 NKAPL 0.45 7.14 0.37 5.87e-12 Depression; CRC cis rs11764590 0.715 rs9639202 chr7:2087315 G/A cg21155852 chr7:2048760 MAD1L1 -0.46 -5.98 -0.31 5.77e-9 Neuroticism; CRC cis rs9488822 0.676 rs868943 chr6:116337503 G/A cg18764771 chr6:116381957 FRK 0.25 7.1 0.36 7.67e-12 Cholesterol, total;LDL cholesterol; CRC cis rs9372498 0.536 rs62422236 chr6:118972633 G/T cg24463073 chr6:118973353 C6orf204 0.52 6.55 0.34 2.24e-10 Diastolic blood pressure; CRC cis rs2880765 0.527 rs1483578 chr15:86075417 A/G cg20737812 chr15:86336631 KLHL25 -0.34 -5.64 -0.3 3.74e-8 Coronary artery disease; CRC cis rs364477 0.904 rs279897 chr9:966257 T/G cg13952963 chr9:998547 NA 0.57 6.21 0.32 1.61e-9 Major depressive disorder; CRC cis rs7223966 1.000 rs8075257 chr17:61728750 G/C cg23903597 chr17:61704154 MAP3K3 -0.42 -5.64 -0.3 3.67e-8 Hip circumference adjusted for BMI;Body mass index; CRC cis rs6951245 1.000 rs78308415 chr7:1072634 G/A cg21664854 chr7:1097933 C7orf50;GPR146 0.79 8.87 0.44 4.67e-17 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs2415984 0.622 rs2415998 chr14:46930712 A/G cg14871534 chr14:47121158 RPL10L -0.43 -6.16 -0.32 2.17e-9 Number of children ever born; CRC cis rs9611565 0.592 rs5751101 chr22:41828111 C/T cg06481639 chr22:41940642 POLR3H 0.54 5.81 0.3 1.49e-8 Vitiligo; CRC cis rs9549367 0.713 rs9549356 chr13:113851633 A/G cg00898013 chr13:113819073 PROZ -0.59 -8.21 -0.41 5.1e-15 Platelet distribution width; CRC trans rs4538475 0.790 rs11934811 chr4:15738253 A/G cg13752949 chr16:19535313 CP110 0.57 6.03 0.32 4.53e-9 Parkinson's disease; CRC cis rs6502050 0.835 rs4789722 chr17:80151881 G/A cg02741985 chr17:80059408 CCDC57 0.44 7.29 0.37 2.3e-12 Life satisfaction; CRC cis rs7833986 1.000 rs36103212 chr8:57101475 G/T cg23139584 chr8:56987506 RPS20;SNORD54 0.62 7.79 0.39 8.9e-14 Height; CRC cis rs995000 0.965 rs10889332 chr1:62950858 A/G cg19896129 chr1:63156450 NA -0.41 -6.13 -0.32 2.46e-9 Triglyceride levels; CRC cis rs1003719 0.699 rs1015549 chr21:38448880 T/C cg10648535 chr21:38446584 PIGP;TTC3 0.53 7.54 0.38 4.76e-13 Eye color traits; CRC cis rs10504229 0.593 rs113184543 chr8:58042950 A/G cg22535103 chr8:58192502 C8orf71 -0.45 -6.1 -0.32 2.9e-9 Developmental language disorder (linguistic errors); CRC cis rs919433 0.929 rs7592511 chr2:198177974 A/G cg10820045 chr2:198174542 NA -0.56 -11.51 -0.54 5.49e-26 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg00295448 chr5:140044129 WDR55 0.58 8.39 0.42 1.42e-15 Response to antipsychotic treatment; CRC cis rs7618915 0.571 rs12487445 chr3:52618319 A/C cg15147215 chr3:52552868 STAB1 -0.62 -10.32 -0.49 8e-22 Bipolar disorder; CRC cis rs9409565 0.586 rs9409547 chr9:97212196 A/C cg04523069 chr9:97136363 HIATL1 0.43 5.98 0.31 5.7e-9 Colorectal cancer (alcohol consumption interaction); CRC cis rs12760731 0.565 rs12027723 chr1:178090271 A/T cg00404053 chr1:178313656 RASAL2 1.07 11.38 0.53 1.64e-25 Obesity-related traits; CRC cis rs1387259 0.931 rs11168474 chr12:48621384 A/C cg24011408 chr12:48396354 COL2A1 0.44 6.1 0.32 3.03e-9 Obstructive sleep apnea trait (apnea hypopnea index); CRC cis rs9467711 0.606 rs9393718 chr6:26407482 G/A cg14345882 chr6:26364793 BTN3A2 0.74 6.09 0.32 3.23e-9 Autism spectrum disorder or schizophrenia; CRC cis rs7727544 0.507 rs10051679 chr5:131570931 T/A cg22638593 chr5:131593259 PDLIM4 0.48 8.69 0.43 1.74e-16 Blood metabolite levels; CRC cis rs9814567 0.806 rs2293293 chr3:134322742 A/G cg06109529 chr3:134205091 CEP63;ANAPC13 -0.69 -10.27 -0.49 1.25e-21 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs6701037 1.000 rs12747817 chr1:175118895 C/T cg00321850 chr1:175162397 KIAA0040 -0.36 -5.89 -0.31 9.48e-9 Alcohol dependence; CRC cis rs3741404 0.825 rs2845597 chr11:63954370 G/A cg19465662 chr11:63993652 NUDT22;TRPT1 0.83 13.69 0.6 4.67e-34 Platelet count; CRC cis rs826838 1.000 rs7953227 chr12:38946193 G/A cg13010199 chr12:38710504 ALG10B 0.45 5.93 0.31 7.84e-9 Heart rate; CRC cis rs4925540 0.724 rs2453407 chr1:247172257 A/G cg22502715 chr1:247171572 ZNF695 -0.44 -6.5 -0.34 2.93e-10 Response to taxane treatment (docetaxel); CRC cis rs853679 0.824 rs34712084 chr6:28043828 A/G cg15845792 chr6:28175446 NA 0.77 6.27 0.33 1.12e-9 Depression; CRC cis rs35306767 0.903 rs11253495 chr10:937064 C/T cg26597838 chr10:835615 NA 0.97 11.69 0.54 1.21e-26 Eosinophil percentage of granulocytes; CRC cis rs6121246 0.567 rs6060249 chr20:30190944 G/A cg18721089 chr20:30220636 NA -0.52 -7.93 -0.4 3.54e-14 Mean corpuscular hemoglobin; CRC cis rs951366 0.789 rs823094 chr1:205689807 G/T cg26354017 chr1:205819088 PM20D1 -0.72 -11.3 -0.53 3.12e-25 Menarche (age at onset); CRC cis rs4665809 1.000 rs1550382 chr2:26266877 T/G cg22920501 chr2:26401640 FAM59B -0.52 -7.11 -0.36 7.33e-12 Gut microbiome composition (summer); CRC cis rs5751150 1 rs5751150 chr22:42153292 T/G cg06481639 chr22:41940642 POLR3H 0.55 6.11 0.32 2.76e-9 Cannabis dependence symptom count; CRC cis rs875971 0.830 rs809025 chr7:65849819 C/G cg00343986 chr7:65444356 GUSB 0.41 5.87 0.31 1.09e-8 Aortic root size; CRC cis rs13191362 1.000 rs34443622 chr6:163208214 T/C cg23758597 chr6:163146217 PARK2 -0.68 -6.91 -0.36 2.46e-11 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs743757 0.816 rs6792502 chr3:50531201 C/A cg12708802 chr3:50388878 TUSC4;CYB561D2 0.4 5.77 0.3 1.86e-8 Diastolic blood pressure; CRC cis rs9549260 0.755 rs2721069 chr13:41143720 C/T cg21288729 chr13:41239152 FOXO1 0.4 6.1 0.32 3.05e-9 Red blood cell count; CRC cis rs7224685 0.501 rs2727064 chr17:3934101 A/G cg11204139 chr17:3907470 NA 0.74 13.48 0.6 2.91e-33 Type 2 diabetes; CRC cis rs769267 0.965 rs8101938 chr19:19390497 G/A cg03709012 chr19:19516395 GATAD2A 0.72 10.98 0.52 4.29e-24 Tonsillectomy; CRC cis rs7843479 1.000 rs17615788 chr8:21814739 C/T cg17168535 chr8:21777572 XPO7 0.55 8.93 0.44 2.99e-17 Mean corpuscular volume; CRC cis rs1881797 0.872 rs12408686 chr1:247691141 C/T cg21399703 chr1:247681439 NA 0.52 8.38 0.42 1.59e-15 Acute lymphoblastic leukemia (childhood); CRC cis rs3768617 0.510 rs3765521 chr1:183077615 C/T ch.1.3577855R chr1:183094577 LAMC1 0.9 15.78 0.66 3.81e-42 Fuchs's corneal dystrophy; CRC cis rs72781680 1.000 rs111229211 chr2:24167417 T/G cg08917208 chr2:24149416 ATAD2B 0.9 8.35 0.42 1.92e-15 Lymphocyte counts; CRC cis rs55823223 0.564 rs1463485 chr17:73851791 C/G cg10935138 chr17:73851978 WBP2 0.52 6.56 0.34 2.08e-10 Psoriasis; CRC cis rs10256972 0.681 rs6979076 chr7:1116247 C/T cg27094323 chr7:1216898 NA 0.38 6.21 0.32 1.58e-9 Longevity;Endometriosis; CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg11081941 chr7:30518533 NOD1 0.38 6.32 0.33 8.67e-10 Obesity-related traits; CRC cis rs651907 0.557 rs13069443 chr3:101373305 C/T cg12386194 chr3:101231763 SENP7 0.49 7.11 0.36 7.34e-12 Colorectal cancer; CRC cis rs7762018 1.000 rs7746598 chr6:170084933 T/A cg17545662 chr6:170176663 C6orf70 0.54 5.98 0.31 5.71e-9 Thiazide-induced adverse metabolic effects in hypertensive patients; CRC cis rs4665809 0.627 rs13032756 chr2:26489730 A/T cg08067268 chr2:26466485 HADHB;HADHA 0.63 8.13 0.41 8.77e-15 Gut microbiome composition (summer); CRC cis rs798554 0.679 rs2527681 chr7:2892384 A/T cg13628971 chr7:2884303 GNA12 0.64 9.08 0.45 1.02e-17 Height; CRC cis rs11123170 0.650 rs2289897 chr2:113977454 G/A cg07772999 chr2:113993052 PAX8;LOC440839;LOC654433 0.52 6.21 0.32 1.55e-9 Renal function-related traits (BUN); CRC cis rs1008375 1.000 rs3846357 chr4:17635887 A/T cg02297831 chr4:17616191 MED28 0.44 5.79 0.3 1.65e-8 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs10189230 0.643 rs2710503 chr2:222374699 C/G cg14652038 chr2:222343519 EPHA4 -0.33 -5.66 -0.3 3.35e-8 Urate levels in lean individuals; CRC cis rs2991971 1.000 rs9147 chr1:46016687 T/C cg15605315 chr1:45957053 TESK2 0.43 6.62 0.34 1.48e-10 High light scatter reticulocyte count; CRC cis rs1005277 0.522 rs289643 chr10:37941494 T/G cg00409905 chr10:38381863 ZNF37A -0.57 -8.86 -0.44 5.04e-17 Extrinsic epigenetic age acceleration; CRC cis rs1564271 0.506 rs1148163 chr10:26929671 G/C cg24343755 chr10:26987087 PDSS1 -0.5 -6.4 -0.33 5.22e-10 Overall survival in serous epithelial ovarian cancer treated with paclitaxel and cisplatin; CRC cis rs57221529 0.766 rs17497684 chr5:558307 T/C cg16447950 chr5:562315 NA -0.84 -11.42 -0.53 1.19e-25 Lung disease severity in cystic fibrosis; CRC cis rs10504073 0.584 rs7820270 chr8:49971395 G/T cg00325661 chr8:49890786 NA 0.55 10.01 0.48 9.31e-21 Blood metabolite ratios; CRC cis rs8013055 0.796 rs8005568 chr14:105971794 A/G cg25008857 chr14:105974488 NA 0.52 7.88 0.4 4.91e-14 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis); CRC cis rs4930103 0.711 rs217710 chr11:2007244 C/T cg23202291 chr11:1979235 NA 0.51 7.5 0.38 5.92e-13 DNA methylation (parent-of-origin);DNA methylation (variation); CRC cis rs1129187 0.755 rs4714638 chr6:42917017 A/G cg09436375 chr6:42928200 GNMT -0.34 -6.18 -0.32 1.91e-9 Alzheimer's disease in APOE e4+ carriers; CRC cis rs6896969 0.510 rs10042027 chr5:40428811 G/A cg09067459 chr5:40385259 NA 0.45 7.75 0.39 1.19e-13 Multiple sclerosis; CRC trans rs7613875 0.600 rs2247510 chr3:50126215 A/C cg21659725 chr3:3221576 CRBN 0.46 6.72 0.35 8.23e-11 Body mass index; CRC cis rs2075371 0.932 rs2241332 chr7:133969439 A/G cg20476274 chr7:133979776 SLC35B4 0.71 11.6 0.54 2.54e-26 Mean platelet volume; CRC cis rs3008870 0.883 rs2755249 chr1:67493662 A/G cg08660285 chr1:67390436 MIER1;WDR78 1.01 14.71 0.63 5.5e-38 Lymphocyte percentage of white cells; CRC cis rs1538970 0.781 rs10890330 chr1:45920406 G/A cg05343316 chr1:45956843 TESK2 0.77 10.29 0.49 1.06e-21 Platelet count; CRC cis rs2976388 0.609 rs2717601 chr8:143807924 T/C cg15511327 chr8:143859410 LYNX1 0.41 7.15 0.37 5.7e-12 Urinary tract infection frequency; CRC cis rs920590 0.758 rs7010174 chr8:19661930 G/C cg03894339 chr8:19674705 INTS10 0.42 5.73 0.3 2.21e-8 Acute lymphoblastic leukemia (childhood); CRC trans rs10983614 1.000 rs7867776 chr9:120072627 A/G cg14872888 chr22:39189885 DNAL4 0.45 6.36 0.33 6.56e-10 Survival in pancreatic cancer; CRC trans rs875971 0.660 rs2191268 chr7:66110224 C/T cg03086376 chr16:1876114 HAGH;FAHD1 -0.42 -6.73 -0.35 7.36e-11 Aortic root size; CRC cis rs2179367 0.959 rs9285519 chr6:149692935 G/A cg11245181 chr6:149772854 ZC3H12D -0.42 -6.62 -0.34 1.48e-10 Dupuytren's disease; CRC cis rs8114671 0.562 rs6087643 chr20:33474462 C/T cg07148914 chr20:33460835 GGT7 0.38 6.36 0.33 6.76e-10 Height; CRC cis rs6977660 0.714 rs10260866 chr7:19793151 T/C cg07541023 chr7:19748670 TWISTNB 0.6 6.07 0.32 3.44e-9 Thyroid stimulating hormone; CRC cis rs2066819 1.000 rs2643626 chr12:56726518 C/T cg26714650 chr12:56694279 CS 1.1 12.65 0.57 3.66e-30 Psoriasis vulgaris; CRC cis rs798554 0.959 rs798558 chr7:2758935 T/G cg14895029 chr7:2775587 GNA12 -0.4 -5.97 -0.31 6.15e-9 Height; CRC cis rs13191362 1.000 rs34714518 chr6:163080778 G/A cg14584255 chr6:163149320 PACRG;PARK2 0.43 6.14 0.32 2.38e-9 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC trans rs2727020 0.688 rs2734002 chr11:49234162 A/G cg11707556 chr5:10655725 ANKRD33B 0.38 6.96 0.36 1.88e-11 Coronary artery disease; CRC cis rs2380220 0.808 rs2386669 chr6:95902121 C/T cg04719120 chr6:96025338 MANEA -0.53 -5.88 -0.31 9.93e-9 Behavioural disinhibition (generation interaction); CRC cis rs7845219 0.597 rs7002058 chr8:95873993 G/C cg23172400 chr8:95962367 TP53INP1 -0.42 -6.83 -0.35 4.1e-11 Type 2 diabetes; CRC cis rs1448094 0.512 rs11832503 chr12:86240797 A/G cg18827107 chr12:86230957 RASSF9 -0.46 -7.54 -0.38 4.63e-13 Major depressive disorder; CRC cis rs17713451 0.593 rs7807134 chr7:151268590 T/C cg18404559 chr7:151322523 PRKAG2 -0.57 -6.41 -0.33 5.12e-10 Interleukin-4 levels; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg06671352 chr3:128399555 NA 0.47 6.63 0.34 1.34e-10 Response to antipsychotic treatment; CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg01084379 chr5:179160712 MAML1 0.4 6.41 0.33 5.12e-10 Obesity-related traits; CRC cis rs2549003 1.000 rs2548999 chr5:131831058 G/T cg02551604 chr5:131831745 NA 0.57 8.88 0.44 4.34e-17 Asthma (sex interaction); CRC cis rs10876993 0.890 rs12302351 chr12:58062590 T/C cg15848620 chr12:58087721 OS9 -0.63 -8.58 -0.43 3.87e-16 Celiac disease or Rheumatoid arthritis; CRC cis rs7552404 0.961 rs17587071 chr1:76225083 A/C cg10523679 chr1:76189770 ACADM 0.85 11.78 0.54 5.91e-27 Blood metabolite levels;Acylcarnitine levels; CRC cis rs2153535 0.580 rs9393019 chr6:8462091 G/A cg21535247 chr6:8435926 SLC35B3 0.5 7.58 0.39 3.54e-13 Motion sickness; CRC cis rs7615952 0.599 rs67575510 chr3:125742355 C/G cg02807482 chr3:125708958 NA -0.45 -5.65 -0.3 3.39e-8 Blood pressure (smoking interaction); CRC cis rs2976388 0.590 rs3736011 chr8:143817789 G/A cg20041105 chr8:143859282 LYNX1 -0.42 -6.94 -0.36 2.06e-11 Urinary tract infection frequency; CRC cis rs71403859 0.685 rs12444890 chr16:71636026 G/A cg08717414 chr16:71523259 ZNF19 -1.14 -10.91 -0.52 7.62e-24 Post bronchodilator FEV1; CRC cis rs2549003 1.000 rs3846732 chr5:131816087 T/C cg00255919 chr5:131827918 IRF1 0.59 11.92 0.55 1.8e-27 Asthma (sex interaction); CRC cis rs3741404 0.560 rs12362602 chr11:63908660 G/A cg15107132 chr11:63991130 FERMT3 0.45 7.73 0.39 1.33e-13 Platelet count; CRC cis rs4523957 0.820 rs7212249 chr17:2135980 A/T cg16513277 chr17:2031491 SMG6 -0.52 -8.9 -0.44 3.78e-17 Autism spectrum disorder or schizophrenia;Schizophrenia; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg08744461 chr12:108079556 PWP1 0.44 6.08 0.32 3.36e-9 Anxiety disorder; CRC cis rs1465370 0.682 rs741486 chr7:130024010 C/T cg03229158 chr7:130009420 NA -0.42 -6.2 -0.32 1.71e-9 Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction);Waist circumference adjusted for BMI in active individuals;Waist circumference adjusted for body mass index; CRC trans rs1814175 0.587 rs7948538 chr11:50021353 A/C cg15704280 chr7:45808275 SEPT13 -0.93 -17.22 -0.69 7.71e-48 Height; CRC cis rs6088590 0.561 rs3891369 chr20:33161127 C/T cg24642439 chr20:33292090 TP53INP2 0.41 7.02 0.36 1.28e-11 Coronary artery disease; CRC cis rs11864453 0.826 rs12448315 chr16:72147242 G/T cg23815491 chr16:72088622 HP 0.52 8.02 0.4 1.83e-14 Fibrinogen levels; CRC trans rs35110281 1.000 rs35110281 chr21:45068947 T/A cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.54 9.17 0.45 5.23e-18 Mean corpuscular volume; CRC trans rs875971 0.660 rs2191268 chr7:66110224 C/T cg14640751 chr11:111636595 PPP2R1B -0.39 -6.11 -0.32 2.76e-9 Aortic root size; CRC cis rs514406 0.584 rs7524702 chr1:53197830 G/A cg08859206 chr1:53392774 SCP2 0.42 6.48 0.34 3.31e-10 Monocyte count; CRC cis rs2243480 1.000 rs313832 chr7:65550891 G/T cg25985355 chr7:65971099 NA -0.48 -5.67 -0.3 3.15e-8 Diabetic kidney disease; CRC cis rs35306767 0.669 rs2101051 chr10:1158791 G/T cg20503657 chr10:835505 NA 0.74 8.4 0.42 1.4e-15 Eosinophil percentage of granulocytes; CRC cis rs17345786 0.906 rs72940399 chr3:101122575 A/T cg11279151 chr3:101281821 RG9MTD1 -0.67 -8.41 -0.42 1.27e-15 Colonoscopy-negative controls vs population controls; CRC cis rs6662572 0.737 rs9429091 chr1:46513088 C/T cg03123370 chr1:45965343 CCDC163P;MMACHC 0.47 6.12 0.32 2.63e-9 Blood protein levels; CRC cis rs6933660 0.676 rs3757316 chr6:151774339 A/G cg10883421 chr6:151773342 RMND1;C6orf211 -0.67 -10.77 -0.51 2.26e-23 Menarche (age at onset); CRC cis rs9467773 0.620 rs2494692 chr6:26615223 G/A cg09904177 chr6:26538194 HMGN4 0.72 11.24 0.53 5.19e-25 Intelligence (multi-trait analysis); CRC cis rs79349575 0.756 rs2643361 chr17:46977462 T/G cg00947319 chr17:47005597 UBE2Z -0.34 -5.93 -0.31 7.7e-9 Type 2 diabetes; CRC cis rs939584 1.000 rs13412194 chr2:653245 A/C cg03610516 chr2:642275 NA -0.42 -5.74 -0.3 2.18e-8 Body mass index; CRC cis rs172166 0.637 rs1071893 chr6:28167635 G/C cg02683197 chr6:28174875 NA 0.73 10.73 0.51 3.07e-23 Cardiac Troponin-T levels; CRC cis rs13108904 0.901 rs4974594 chr4:1300480 C/T cg20092199 chr4:1342459 KIAA1530 -0.39 -6.88 -0.35 2.94e-11 Obesity-related traits; CRC cis rs9311474 0.507 rs6787154 chr3:52784416 C/T cg10802521 chr3:52805072 NEK4 -0.57 -8.93 -0.44 3.01e-17 Electroencephalogram traits; CRC cis rs67311347 0.955 rs6773383 chr3:40377412 A/T cg24209194 chr3:40518798 ZNF619 0.42 6.46 0.34 3.75e-10 Renal cell carcinoma; CRC cis rs6460942 1.000 rs62448568 chr7:12407445 A/G cg06484146 chr7:12443880 VWDE -0.74 -7.7 -0.39 1.63e-13 Coronary artery disease; CRC cis rs9916302 0.706 rs11655972 chr17:37407072 C/T cg07936489 chr17:37558343 FBXL20 -0.87 -10.92 -0.52 6.55e-24 Glomerular filtration rate (creatinine); CRC trans rs11098499 0.739 rs4833612 chr4:120147596 A/C cg25214090 chr10:38739885 LOC399744 -0.42 -6.72 -0.35 7.89e-11 Corneal astigmatism; CRC cis rs9311474 0.629 rs13081028 chr3:52555316 G/A cg18591801 chr3:52553433 STAB1 -0.31 -5.89 -0.31 9.5e-9 Electroencephalogram traits; CRC cis rs651907 0.557 rs2318090 chr3:101474933 A/G cg11279151 chr3:101281821 RG9MTD1 -0.48 -6.5 -0.34 3.02e-10 Colorectal cancer; CRC cis rs34526934 0.608 rs34720456 chr2:177027292 G/A cg10305451 chr2:177043427 NA -0.53 -6.85 -0.35 3.71e-11 Obstructive sleep apnea trait (apnea hypopnea index); CRC cis rs2832191 0.716 rs1888439 chr21:30454457 A/G cg24692254 chr21:30365293 RNF160 0.82 14.69 0.63 6.75e-38 Dental caries; CRC trans rs11098499 0.954 rs6834796 chr4:120414693 A/C cg25214090 chr10:38739885 LOC399744 0.66 10.47 0.5 2.39e-22 Corneal astigmatism; CRC cis rs728616 0.867 rs55690691 chr10:81658942 G/T cg05935833 chr10:81318306 SFTPA2 -0.7 -7.74 -0.39 1.21e-13 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs9443645 0.527 rs2105143 chr6:79742947 G/A cg09184832 chr6:79620586 NA -0.45 -7.75 -0.39 1.19e-13 Intelligence (multi-trait analysis); CRC cis rs8044868 0.530 rs8059437 chr16:72116467 A/G cg23815491 chr16:72088622 HP 0.45 6.59 0.34 1.79e-10 Body mass index (change over time) in cancer or chronic obstructive pulmonary disease;Body mass index (change over time) in cancer; CRC cis rs9322193 0.809 rs9479808 chr6:150072464 A/T cg05861140 chr6:150128134 PCMT1 -0.36 -5.83 -0.31 1.31e-8 Lung cancer; CRC cis rs10540 0.908 rs1044707 chr11:491334 G/T cg15790184 chr11:494944 RNH1 -0.6 -6.28 -0.33 1.06e-9 Body mass index; CRC cis rs2839186 0.616 rs4819213 chr21:47619300 G/A cg11766577 chr21:47581405 C21orf56 0.4 6.41 0.33 5.03e-10 Testicular germ cell tumor; CRC cis rs12505749 0.542 rs12505939 chr4:57364210 T/C cg06922635 chr4:57371607 ARL9 -0.54 -5.71 -0.3 2.54e-8 Airflow obstruction; CRC cis rs9914544 0.564 rs1859083 chr17:18843306 C/T cg26378065 chr17:18585709 ZNF286B -0.43 -6.76 -0.35 6.42e-11 Educational attainment (years of education); CRC cis rs7727544 0.716 rs72793283 chr5:131566941 G/A cg14196790 chr5:131705035 SLC22A5 0.35 6.12 0.32 2.66e-9 Blood metabolite levels; CRC cis rs10504229 0.906 rs113745779 chr8:58191301 C/G cg02725872 chr8:58115012 NA -0.38 -6.43 -0.33 4.44e-10 Developmental language disorder (linguistic errors); CRC trans rs57221529 0.545 rs55955015 chr5:575182 A/G cg25482853 chr8:67687455 SGK3 1.22 14.86 0.63 1.43e-38 Lung disease severity in cystic fibrosis; CRC cis rs4478858 0.647 rs7524117 chr1:31738416 A/G cg00250761 chr1:31883323 NA -0.43 -8.38 -0.42 1.55e-15 Alcohol dependence; CRC trans rs7939886 0.920 rs11227180 chr11:55855611 G/C cg03929089 chr4:120376271 NA 0.66 5.96 0.31 6.38e-9 Myopia (pathological); CRC cis rs13392177 0.660 rs10932762 chr2:219076213 G/C cg04880052 chr2:219191631 PNKD -0.39 -5.89 -0.31 9.54e-9 Pyoderma gangrenosum in inflammatory bowel disease; CRC cis rs7927771 0.832 rs6485753 chr11:47410200 C/T cg05585544 chr11:47624801 NA 0.53 9.3 0.46 2.09e-18 Subjective well-being; CRC cis rs2204008 0.630 rs12306932 chr12:38242029 C/T cg26384229 chr12:38710491 ALG10B -0.54 -7.68 -0.39 1.83e-13 Bladder cancer; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg12111933 chr18:72265022 LOC400657 0.49 7.21 0.37 3.81e-12 Response to antipsychotic treatment; CRC cis rs7524258 0.868 rs4908451 chr1:7299618 C/G cg07173049 chr1:7289937 CAMTA1 -0.56 -9.33 -0.46 1.58e-18 Tourette's syndrome or obsessive-compulsive disorder; CRC cis rs7937682 0.889 rs11213969 chr11:111528441 A/G cg09085632 chr11:111637200 PPP2R1B -1.02 -20.96 -0.76 1.47e-62 Primary sclerosing cholangitis; CRC cis rs2795502 0.935 rs2744060 chr10:43262616 C/G cg20628663 chr10:43360327 NA -0.65 -8.0 -0.4 2.19e-14 Blood protein levels; CRC cis rs10256972 0.552 rs2949192 chr7:1203841 C/T cg23978390 chr7:1156363 C7orf50 0.48 6.77 0.35 6.1e-11 Longevity;Endometriosis; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg07780856 chr3:183967543 ALG3;ECE2 0.48 6.43 0.33 4.43e-10 Anxiety disorder; CRC trans rs6076960 0.652 rs3852946 chr20:6255311 C/T cg17788362 chr6:86352627 SYNCRIP 0.51 7.41 0.38 1.06e-12 Smooth-surface caries; CRC cis rs9649213 0.593 rs3779194 chr7:98010277 A/G cg00277769 chr7:97922759 BAIAP2L1 -0.59 -10.1 -0.49 4.6e-21 Prostate cancer (SNP x SNP interaction); CRC cis rs870825 0.616 rs4594761 chr4:185643002 A/C cg04058563 chr4:185651563 MLF1IP 0.72 9.42 0.46 8.15e-19 Blood protein levels; CRC cis rs2732480 0.557 rs2409004 chr12:48721451 T/C cg21466736 chr12:48725269 NA -0.59 -8.95 -0.44 2.63e-17 Hemoglobin concentration;Red blood cell count;Hematocrit; CRC cis rs1552244 1.000 rs7648104 chr3:10073311 C/A cg02579736 chr3:10068473 FANCD2;CIDECP 1.05 14.06 0.61 1.71e-35 Alzheimer's disease; CRC cis rs7208859 0.623 rs1054400 chr17:29109954 A/G cg13385521 chr17:29058706 SUZ12P 0.73 8.4 0.42 1.39e-15 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg07472398 chr5:130501141 HINT1 0.43 6.11 0.32 2.77e-9 Intelligence (multi-trait analysis); CRC cis rs6502050 0.835 rs8078950 chr17:80122327 T/G cg02741985 chr17:80059408 CCDC57 0.43 7.15 0.37 5.59e-12 Life satisfaction; CRC cis rs61008539 0.893 rs11765528 chr7:861952 C/T cg00475322 chr7:917719 C7orf20 0.44 7.76 0.39 1.07e-13 Perceived unattractiveness to mosquitoes; CRC cis rs9640161 0.742 rs2108852 chr7:150019628 T/C cg12556325 chr7:150026731 C7orf29;LRRC61 -0.44 -6.42 -0.33 4.63e-10 Blood protein levels;Circulating chemerin levels; CRC cis rs10751667 0.666 rs7394427 chr11:970405 G/A cg01483505 chr11:975446 AP2A2 0.46 7.66 0.39 2.11e-13 Alzheimer's disease (late onset); CRC cis rs17711722 0.653 rs2460421 chr7:65491123 A/T cg00343986 chr7:65444356 GUSB -0.54 -7.9 -0.4 4.2e-14 Calcium levels; CRC cis rs13315871 1.000 rs9864824 chr3:58394835 A/G cg20936604 chr3:58311152 NA 0.73 7.0 0.36 1.49e-11 Cholesterol, total; CRC cis rs1448094 0.512 rs7970081 chr12:86243392 G/T cg00310523 chr12:86230176 RASSF9 0.33 5.62 0.3 3.97e-8 Major depressive disorder; CRC cis rs6089584 0.888 rs2386555 chr20:60612373 C/T cg13770153 chr20:60521292 NA -0.58 -8.79 -0.44 8.37e-17 Body mass index; CRC cis rs1799949 1.000 rs4340367 chr17:41307772 G/A cg23758822 chr17:41437982 NA 0.8 13.63 0.6 7.81e-34 Menopause (age at onset); CRC cis rs9807989 0.839 rs1974675 chr2:102986375 G/A cg03938978 chr2:103052716 IL18RAP 0.36 5.84 0.31 1.23e-8 Asthma; CRC cis rs17127169 0.536 rs74860172 chr1:65497547 T/A cg11989330 chr1:65468827 NA 0.89 6.32 0.33 8.3e-10 Sitting height ratio; CRC cis rs2635047 0.935 rs2461247 chr18:44698537 T/G cg19077165 chr18:44547161 KATNAL2 -0.45 -7.21 -0.37 3.78e-12 Educational attainment; CRC trans rs1814175 0.935 rs1827017 chr11:49632592 C/G cg15704280 chr7:45808275 SEPT13 -0.97 -18.03 -0.7 5.04e-51 Height; CRC cis rs6582630 0.537 rs1949610 chr12:38387838 C/T cg13010199 chr12:38710504 ALG10B 0.47 6.3 0.33 9.3e-10 Drug-induced liver injury (flucloxacillin); CRC cis rs1865760 0.892 rs2328903 chr6:25935765 T/C cg17691542 chr6:26056736 HIST1H1C 0.54 7.69 0.39 1.74e-13 Height; CRC cis rs17155006 0.691 rs403731 chr7:107744217 C/T cg05962710 chr7:107745446 LAMB4 0.41 7.36 0.38 1.48e-12 Pneumococcal bacteremia; CRC cis rs995000 0.931 rs624660 chr1:62920388 C/A cg19896129 chr1:63156450 NA 0.44 6.78 0.35 5.59e-11 Triglyceride levels; CRC cis rs4731207 0.671 rs7811607 chr7:124447843 T/G cg23710748 chr7:124431027 NA 0.37 5.96 0.31 6.53e-9 Cutaneous malignant melanoma; CRC cis rs12048904 0.647 rs7528268 chr1:101329295 A/G cg00063077 chr1:101360652 SLC30A7;EXTL2 0.79 12.13 0.56 2.97e-28 Multiple sclerosis; CRC cis rs561341 0.882 rs16967101 chr17:30377162 A/G cg19193384 chr17:30244184 NA -0.51 -6.72 -0.35 8.04e-11 Hip circumference adjusted for BMI; CRC cis rs7584330 0.554 rs6739456 chr2:238385092 G/C cg16989719 chr2:238392110 NA -0.43 -6.12 -0.32 2.72e-9 Prostate cancer; CRC cis rs728616 0.867 rs12414521 chr10:81949534 G/C cg05935833 chr10:81318306 SFTPA2 -0.75 -8.19 -0.41 5.8e-15 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs9911578 0.967 rs1588322 chr17:56990099 T/C cg05425664 chr17:57184151 TRIM37 -0.5 -7.81 -0.4 7.69e-14 Intelligence (multi-trait analysis); CRC cis rs7762018 1.000 rs17860606 chr6:170099561 G/A cg19338460 chr6:170058176 WDR27 -0.74 -8.09 -0.41 1.14e-14 Thiazide-induced adverse metabolic effects in hypertensive patients; CRC cis rs908922 0.676 rs7545336 chr1:152527863 A/G cg23254163 chr1:152506842 NA 0.45 9.13 0.45 6.92e-18 Hair morphology; CRC cis rs9911578 1.000 rs9902994 chr17:56948722 T/A cg05425664 chr17:57184151 TRIM37 -0.49 -7.77 -0.39 9.89e-14 Intelligence (multi-trait analysis); CRC cis rs10504229 0.679 rs7813252 chr8:58136389 C/G cg04204079 chr8:58130323 NA -0.45 -5.91 -0.31 8.33e-9 Developmental language disorder (linguistic errors); CRC cis rs1448094 0.512 rs12313775 chr12:86241197 G/A cg02569458 chr12:86230093 RASSF9 0.42 7.24 0.37 3.17e-12 Major depressive disorder; CRC cis rs34779708 0.931 rs35388511 chr10:35296616 A/G cg03585969 chr10:35415529 CREM 0.65 8.78 0.44 9.01e-17 Inflammatory bowel disease;Crohn's disease; CRC cis rs4654899 1.000 rs6703227 chr1:21374810 A/G cg02927042 chr1:21476669 EIF4G3 -0.48 -7.64 -0.39 2.43e-13 Superior frontal gyrus grey matter volume; CRC cis rs2625529 0.652 rs2278987 chr15:72409769 T/C cg16672083 chr15:72433130 SENP8 0.45 6.81 0.35 4.77e-11 Red blood cell count; CRC cis rs9326248 1.000 rs664082 chr11:117071070 C/G cg15534755 chr11:117069859 TAGLN 0.35 6.73 0.35 7.5e-11 Blood protein levels; CRC cis rs8038465 0.568 rs62004592 chr15:73878019 A/G cg15420318 chr15:73925796 NPTN 0.45 7.29 0.37 2.35e-12 Liver enzyme levels (gamma-glutamyl transferase); CRC trans rs2303319 0.504 rs12467613 chr2:162603216 G/T cg13490827 chr1:46269305 MAST2 -0.69 -6.0 -0.31 5.24e-9 Cognitive function; CRC cis rs6540559 0.611 rs17015226 chr1:209970096 C/G cg21951975 chr1:209979733 IRF6 0.46 6.16 0.32 2.12e-9 Cleft lip with or without cleft palate; CRC cis rs4689388 0.890 rs4689398 chr4:6302199 C/T cg14416269 chr4:6271139 WFS1 0.39 6.48 0.34 3.35e-10 Type 2 diabetes and other traits;Type 2 diabetes; CRC cis rs9828933 0.752 rs13433909 chr3:63948609 C/G cg16258503 chr3:63850278 ATXN7;THOC7 -0.81 -9.1 -0.45 9.11e-18 Type 2 diabetes; CRC cis rs9911578 1.000 rs172565 chr17:56808996 A/T cg12560992 chr17:57184187 TRIM37 0.9 16.39 0.67 1.5e-44 Intelligence (multi-trait analysis); CRC cis rs67478160 0.619 rs1187416 chr14:104311465 A/G cg01849466 chr14:104193079 ZFYVE21 -0.47 -8.36 -0.42 1.75e-15 Schizophrenia; CRC cis rs10504229 0.683 rs6980850 chr8:58127204 A/G cg24829409 chr8:58192753 C8orf71 -0.55 -8.03 -0.4 1.71e-14 Developmental language disorder (linguistic errors); CRC cis rs6951245 1.000 rs11768761 chr7:1069807 A/G cg24642844 chr7:1081250 C7orf50 -0.78 -9.35 -0.46 1.42e-18 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC trans rs6500957 0.920 rs17648524 chr16:7459683 C/G cg18070033 chr2:220025364 NHEJ1 0.45 6.45 0.34 4.06e-10 Spherical equivalent (joint analysis main effects and education interaction); CRC cis rs6860806 0.507 rs272872 chr5:131675864 C/T cg09877947 chr5:131593287 PDLIM4 -0.41 -6.85 -0.35 3.63e-11 Breast cancer; CRC cis rs738321 0.701 rs4821754 chr22:38581503 A/G cg25457927 chr22:38595422 NA 0.37 6.83 0.35 4.05e-11 Breast cancer; CRC cis rs7927771 0.839 rs59360790 chr11:47669175 T/C cg18512352 chr11:47633146 NA -0.36 -7.08 -0.36 8.58e-12 Subjective well-being; CRC cis rs5753618 0.583 rs34545960 chr22:31812462 G/A cg22777020 chr22:31556080 RNF185 0.53 6.25 0.33 1.25e-9 Colorectal cancer; CRC cis rs539514 0.627 rs9544035 chr13:76293789 C/T cg04757411 chr13:76259545 LMO7 -0.36 -6.08 -0.32 3.38e-9 Type 1 diabetes; CRC cis rs2836974 0.897 rs34599551 chr21:40594898 C/A cg17971929 chr21:40555470 PSMG1 0.84 12.67 0.57 3.24e-30 Cognitive function; CRC trans rs4332037 0.722 rs4719331 chr7:1914679 A/C cg11693508 chr17:37793320 STARD3 0.56 6.95 0.36 2.01e-11 Bipolar disorder; CRC cis rs9309473 1.000 rs13383871 chr2:73631779 T/C cg20560298 chr2:73613845 ALMS1 -0.5 -6.13 -0.32 2.55e-9 Metabolite levels; CRC cis rs950169 0.881 rs4842852 chr15:84941961 A/G cg17507749 chr15:85114479 UBE2QP1 0.74 10.59 0.5 9.91e-23 Schizophrenia; CRC cis rs6570726 0.764 rs76635693 chr6:145834070 T/C cg13319975 chr6:146136371 FBXO30 -0.44 -6.66 -0.34 1.13e-10 Lobe attachment (rater-scored or self-reported); CRC trans rs561341 1.000 rs550923 chr17:30327013 G/C cg27661571 chr11:113659931 NA -0.95 -10.99 -0.52 3.76e-24 Hip circumference adjusted for BMI; CRC cis rs17641971 0.684 rs4873095 chr8:49990166 A/T cg00325661 chr8:49890786 NA 0.37 6.22 0.32 1.51e-9 Blood metabolite levels; CRC cis rs3096299 0.685 rs4785676 chr16:89553624 T/C cg08392591 chr16:89556376 ANKRD11 0.43 5.86 0.31 1.11e-8 Multiple myeloma (IgH translocation); CRC cis rs12540874 0.698 rs12718574 chr7:50573848 G/C cg14593290 chr7:50529359 DDC -0.45 -6.36 -0.33 6.92e-10 Systemic sclerosis; CRC cis rs13108904 0.967 rs4642180 chr4:1278914 T/C cg02018176 chr4:1364513 KIAA1530 0.48 7.88 0.4 4.67e-14 Obesity-related traits; CRC cis rs3796352 1.000 rs11720191 chr3:53013839 T/C cg07884673 chr3:53033167 SFMBT1 0.67 5.89 0.31 9.73e-9 Immune reponse to smallpox (secreted IL-2); CRC cis rs3806843 0.657 rs2563283 chr5:140105978 C/A cg19875535 chr5:140030758 IK -0.63 -10.37 -0.5 5.49e-22 Depressive symptoms (multi-trait analysis); CRC cis rs7659604 0.539 rs7686200 chr4:122764553 C/T cg06713675 chr4:122721982 EXOSC9 -0.53 -8.77 -0.44 9.71e-17 Type 2 diabetes; CRC cis rs12476592 0.602 rs2292793 chr2:63661280 A/G cg10828910 chr2:63850056 LOC388955 0.53 6.5 0.34 3.06e-10 Childhood ear infection; CRC cis rs6496044 0.568 rs11632326 chr15:86079834 A/C cg17133734 chr15:86042851 AKAP13 0.42 6.96 0.36 1.9e-11 Interstitial lung disease; CRC cis rs2179367 0.959 rs4895789 chr6:149764654 T/C cg11245181 chr6:149772854 ZC3H12D -0.43 -6.82 -0.35 4.39e-11 Dupuytren's disease; CRC trans rs11039798 0.660 rs717897 chr11:48375604 A/G cg03929089 chr4:120376271 NA -0.61 -6.43 -0.33 4.44e-10 Axial length; CRC cis rs17433780 0.504 rs1409150 chr1:89473175 A/G cg09516651 chr1:89888402 LOC400759 0.36 5.78 0.3 1.71e-8 Carotid intima media thickness; CRC cis rs79387448 0.745 rs723292 chr2:103166804 A/G cg09003973 chr2:102972529 NA 0.7 7.77 0.39 1.03e-13 Gut microbiota (bacterial taxa); CRC cis rs7072216 0.763 rs2147900 chr10:100174721 T/C cg26618903 chr10:100175079 PYROXD2 -0.55 -8.99 -0.44 2.03e-17 Metabolite levels; CRC trans rs13046373 0.905 rs4816372 chr21:32077414 A/T cg05301359 chr2:27886888 SUPT7L;SLC4A1AP -0.41 -5.97 -0.31 6.15e-9 HDL cholesterol; CRC cis rs9303401 0.659 rs34275691 chr17:56736640 A/T cg02118635 chr17:56770003 RAD51C;TEX14 0.78 9.75 0.47 6.87e-20 Cognitive test performance; CRC trans rs2797160 0.967 rs4897151 chr6:125993202 T/G cg05039488 chr6:79577232 IRAK1BP1 -0.5 -7.51 -0.38 5.79e-13 Endometrial cancer; CRC cis rs13256369 0.951 rs10503394 chr8:8565775 A/G cg17143192 chr8:8559678 CLDN23 0.51 6.7 0.35 9.07e-11 Obesity-related traits; CRC cis rs10504229 0.953 rs72652908 chr8:58191324 G/A cg05313129 chr8:58192883 C8orf71 -0.47 -6.99 -0.36 1.49e-11 Developmental language disorder (linguistic errors); CRC cis rs853679 0.550 rs1233704 chr6:28166923 A/G cg15786705 chr6:28176104 NA -0.81 -11.74 -0.54 8.03e-27 Depression; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg12946690 chr17:2206740 SMG6;SRR 0.44 7.1 0.36 7.81e-12 Liver disease severity in Alagille syndrome; CRC cis rs3806843 0.966 rs10036519 chr5:140151701 C/T cg16607685 chr5:140181889 PCDHA2;PCDHA1;PCDHA3 0.26 5.92 0.31 7.89e-9 Depressive symptoms (multi-trait analysis); CRC cis rs2455799 0.502 rs2470532 chr3:15696909 A/C cg16303742 chr3:15540471 COLQ 0.41 6.57 0.34 1.92e-10 Mean platelet volume; CRC cis rs11212617 0.967 rs227068 chr11:108210109 A/G cg14761454 chr11:108092087 ATM;NPAT 0.43 6.37 0.33 6.43e-10 Response to metformin in type 2 diabetes (glycemic); CRC cis rs13336428 0.730 rs3946124 chr16:1525779 A/G cg07835181 chr16:1525278 CLCN7 -0.69 -11.24 -0.53 4.89e-25 Bone mineral density; CRC cis rs6088580 0.542 rs6059882 chr20:33090167 T/C cg08999081 chr20:33150536 PIGU 0.64 11.81 0.55 4.32e-27 Glomerular filtration rate (creatinine); CRC cis rs7300001 0.667 rs7302198 chr12:110506280 T/C cg12870014 chr12:110450643 ANKRD13A 0.94 9.82 0.48 3.97e-20 Headache; CRC cis rs4660531 1.000 rs4660532 chr1:41840197 C/T cg19619003 chr1:41846758 NA -0.37 -5.88 -0.31 9.98e-9 Bipolar disorder; CRC cis rs7618915 0.547 rs13065019 chr3:52685244 T/C cg18099408 chr3:52552593 STAB1 -0.44 -7.14 -0.37 6.2e-12 Bipolar disorder; CRC cis rs7647973 0.580 rs2117938 chr3:49263850 A/G cg20833759 chr3:49053208 WDR6;DALRD3 -0.39 -6.59 -0.34 1.79e-10 Menarche (age at onset); CRC cis rs1046896 0.553 rs1044661 chr17:80901020 G/A cg19500275 chr17:80737654 TBCD 0.47 6.52 0.34 2.6e-10 Glycated hemoglobin levels; CRC cis rs7666738 0.830 rs10856936 chr4:99011319 T/C cg17366294 chr4:99064904 C4orf37 0.43 7.23 0.37 3.41e-12 Colonoscopy-negative controls vs population controls; CRC cis rs801193 1.000 rs2003301 chr7:66147656 G/C cg25985355 chr7:65971099 NA 0.32 5.64 0.3 3.68e-8 Aortic root size; CRC cis rs35264875 1.000 rs7110274 chr11:68842704 A/G cg15234197 chr11:68924956 NA 0.42 5.77 0.3 1.87e-8 Blond vs. brown hair color; CRC cis rs13266463 0.898 rs13267784 chr8:143394915 C/T cg16886403 chr8:143471632 TSNARE1 0.49 7.11 0.37 7.16e-12 Schizophrenia; CRC cis rs739401 0.595 rs402806 chr11:3066432 A/G cg05729581 chr11:3078854 CARS -0.56 -7.77 -0.39 1.01e-13 Longevity; CRC cis rs870825 0.616 rs56232457 chr4:185628153 T/G cg04058563 chr4:185651563 MLF1IP 0.73 9.5 0.46 4.36e-19 Blood protein levels; CRC cis rs9372498 0.536 rs62424195 chr6:118812108 T/A cg07617317 chr6:118971624 C6orf204 0.5 6.23 0.32 1.44e-9 Diastolic blood pressure; CRC cis rs4713118 0.955 rs9468201 chr6:27687035 C/T cg25164649 chr6:28176230 NA 0.54 7.26 0.37 2.82e-12 Parkinson's disease; CRC cis rs4713118 0.513 rs156734 chr6:28007357 A/C cg06470822 chr6:28175283 NA 0.8 12.1 0.55 4.08e-28 Parkinson's disease; CRC cis rs897984 0.684 rs6950 chr16:30995669 T/C cg02466173 chr16:30829666 NA 0.63 9.58 0.47 2.42e-19 Dementia with Lewy bodies; CRC trans rs1005277 0.579 rs1780138 chr10:38501654 A/G cg27523141 chr10:43048294 ZNF37B 0.47 6.89 0.36 2.87e-11 Extrinsic epigenetic age acceleration; CRC cis rs7119 0.651 rs12915057 chr15:77847745 C/A cg10437265 chr15:77819839 NA 0.59 9.97 0.48 1.23e-20 Type 2 diabetes; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg19733847 chr19:8571072 NA 0.48 6.94 0.36 2.07e-11 Response to antipsychotic treatment; CRC cis rs8177253 0.665 rs8177178 chr3:133463272 G/A cg16262614 chr3:133464971 TF 0.35 5.97 0.31 6.2e-9 Iron status biomarkers; CRC cis rs4713118 0.539 rs200951 chr6:27835930 A/G cg25164649 chr6:28176230 NA 0.58 8.0 0.4 2.09e-14 Parkinson's disease; CRC cis rs4561483 0.603 rs11544193 chr16:12009304 C/A cg08843971 chr16:11963173 GSPT1 0.5 7.46 0.38 7.59e-13 Testicular germ cell tumor; CRC cis rs9494145 0.680 rs9402686 chr6:135427817 G/A cg22676075 chr6:135203613 NA 0.57 7.26 0.37 2.81e-12 Mean platelet volume;Platelet count;Fetal hemoglobin levels in sickle cell anemia;Red blood cell traits; CRC cis rs12701220 0.520 rs7803208 chr7:1162084 C/T cg06145435 chr7:1022769 CYP2W1 0.32 5.62 0.3 4e-8 Bronchopulmonary dysplasia; CRC cis rs11650494 0.908 rs74830554 chr17:47431950 G/A cg08112188 chr17:47440006 ZNF652 1.27 11.79 0.54 5.43e-27 Prostate cancer; CRC cis rs7258465 1.000 rs10403249 chr19:18604942 T/C cg01065977 chr19:18549689 ISYNA1 -0.41 -6.43 -0.33 4.42e-10 Breast cancer; CRC cis rs7618501 0.573 rs2624824 chr3:50088266 T/C cg24110177 chr3:50126178 RBM5 0.53 8.26 0.41 3.66e-15 Intelligence (multi-trait analysis); CRC cis rs6582630 0.502 rs11181475 chr12:38348922 G/A cg13010199 chr12:38710504 ALG10B 0.47 6.42 0.33 4.78e-10 Drug-induced liver injury (flucloxacillin); CRC cis rs305851 0.818 rs6458122 chr6:39769455 C/T cg02386599 chr6:39769542 DAAM2 0.42 6.73 0.35 7.43e-11 Lobe attachment (rater-scored or self-reported); CRC cis rs6867032 1.000 rs16902318 chr5:2013568 A/G cg26168224 chr5:2018326 NA 0.98 17.95 0.7 1.01e-50 Gut microbiome composition (winter); CRC trans rs11098499 0.955 rs1511019 chr4:120166007 T/G cg25214090 chr10:38739885 LOC399744 0.52 8.04 0.41 1.58e-14 Corneal astigmatism; CRC cis rs9611519 1.000 rs9611520 chr22:41613303 C/T cg06634786 chr22:41940651 POLR3H -0.44 -5.61 -0.3 4.24e-8 Neuroticism; CRC cis rs2836974 0.899 rs34978594 chr21:40580003 C/T cg17971929 chr21:40555470 PSMG1 0.83 11.88 0.55 2.55e-27 Cognitive function; CRC trans rs9388451 0.626 rs3799712 chr6:126075103 A/G cg05039488 chr6:79577232 IRAK1BP1 -0.74 -12.93 -0.58 3.24e-31 Brugada syndrome; CRC trans rs11165623 0.564 rs12752866 chr1:97000181 T/C cg10631902 chr5:14652156 NA -0.4 -6.83 -0.35 4.13e-11 Hip circumference;Waist circumference; CRC cis rs10484885 0.553 rs16881936 chr6:90265665 C/T cg13799429 chr6:90582589 CASP8AP2 -0.58 -6.56 -0.34 2.04e-10 QRS interval (sulfonylurea treatment interaction); CRC cis rs8014671 0.553 rs34866539 chr14:70873763 T/C cg25576086 chr14:70833871 SYNJ2BP -0.37 -6.25 -0.33 1.27e-9 Prostate cancer; CRC cis rs116095464 0.558 rs6555055 chr5:226160 A/C cg22496380 chr5:211416 CCDC127 -0.85 -9.83 -0.48 3.67e-20 Breast cancer; CRC cis rs1707322 0.691 rs12031182 chr1:46220999 C/T cg03146154 chr1:46216737 IPP 0.68 9.94 0.48 1.59e-20 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs7811142 0.830 rs78256546 chr7:99952970 A/G cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.15 16.88 0.68 1.67e-46 Platelet count; CRC cis rs6952808 0.595 rs3778982 chr7:2166233 T/C cg02951883 chr7:2050386 MAD1L1 -0.69 -10.63 -0.51 7.02e-23 Bipolar disorder and schizophrenia; CRC cis rs561341 1.000 rs1681718 chr17:30296445 G/A cg19193384 chr17:30244184 NA -0.65 -7.48 -0.38 6.75e-13 Hip circumference adjusted for BMI; CRC trans rs1814175 0.817 rs28679516 chr11:50055998 G/A cg15704280 chr7:45808275 SEPT13 -0.97 -19.11 -0.73 2.72e-55 Height; CRC cis rs4780401 0.609 rs9923954 chr16:11816855 G/T cg01061890 chr16:11836724 TXNDC11 -0.62 -9.25 -0.45 2.96e-18 Rheumatoid arthritis; CRC cis rs763121 0.719 rs138699 chr22:39129708 G/A cg06544989 chr22:39130855 UNC84B 0.44 6.26 0.33 1.21e-9 Menopause (age at onset); CRC cis rs172166 0.538 rs1150686 chr6:28161271 T/G cg10876282 chr6:28092338 ZSCAN16 0.4 5.76 0.3 1.93e-8 Cardiac Troponin-T levels; CRC cis rs28386778 0.897 rs4968662 chr17:61834537 A/G cg06601766 chr17:61851465 DDX42;CCDC47 0.44 5.97 0.31 6.14e-9 Prudent dietary pattern; CRC cis rs7937682 0.814 rs1784788 chr11:111486136 T/G cg09085632 chr11:111637200 PPP2R1B -0.97 -19.08 -0.72 3.46e-55 Primary sclerosing cholangitis; CRC cis rs10744422 1.000 rs921808 chr12:123323135 A/G cg25930673 chr12:123319894 HIP1R 0.54 5.66 0.3 3.33e-8 Schizophrenia; CRC cis rs17023223 0.581 rs61808932 chr1:119643820 T/C cg05756136 chr1:119680316 WARS2 -0.55 -6.94 -0.36 2.06e-11 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for BMI in active individuals; CRC cis rs561341 1.000 rs55978022 chr17:30275937 T/C cg23018236 chr17:30244563 NA -0.65 -7.74 -0.39 1.21e-13 Hip circumference adjusted for BMI; CRC cis rs13108904 0.837 rs4519749 chr4:1280102 A/G cg16405210 chr4:1374714 KIAA1530 -0.44 -6.05 -0.32 3.92e-9 Obesity-related traits; CRC cis rs79349575 0.749 rs2270574 chr17:47022270 C/T cg22482690 chr17:47019901 SNF8 0.48 8.01 0.4 2.01e-14 Type 2 diabetes; CRC cis rs6461049 0.638 rs3778994 chr7:2175855 G/T cg08027265 chr7:2291960 NA -0.36 -6.33 -0.33 8.23e-10 Schizophrenia; CRC cis rs7909074 0.933 rs879073 chr10:45399882 C/G cg05187965 chr10:45406764 TMEM72 -0.37 -8.18 -0.41 6.21e-15 Mean corpuscular volume; CRC cis rs10504229 0.953 rs67677367 chr8:58175264 T/G cg02725872 chr8:58115012 NA -0.38 -6.43 -0.33 4.44e-10 Developmental language disorder (linguistic errors); CRC cis rs3751196 0.708 rs17034464 chr12:104144852 A/T cg02344784 chr12:104178138 NT5DC3 0.69 6.75 0.35 6.79e-11 Sense of smell; CRC cis rs10461617 0.617 rs6874733 chr5:56069600 A/G cg03609598 chr5:56110824 MAP3K1 -0.56 -6.8 -0.35 4.81e-11 Type 2 diabetes; CRC trans rs2303319 0.504 rs60824222 chr2:162368719 A/C cg09481857 chr22:21368659 P2RX6;MGC16703 -0.64 -6.11 -0.32 2.75e-9 Cognitive function; CRC cis rs4713118 0.869 rs9468214 chr6:27713299 G/C cg03623178 chr6:28175578 NA 0.68 9.47 0.46 5.85e-19 Parkinson's disease; CRC cis rs6088813 1.000 rs735531 chr20:33947730 T/C cg14752227 chr20:34000481 UQCC -0.37 -5.81 -0.3 1.49e-8 Height; CRC cis rs1609391 0.543 rs9881139 chr3:136634040 A/G cg15507776 chr3:136538369 TMEM22 0.35 6.27 0.33 1.13e-9 Neuroticism; CRC cis rs7809950 0.817 rs2712195 chr7:107127496 C/T cg23024343 chr7:107201750 COG5 -0.72 -9.94 -0.48 1.58e-20 Coronary artery disease; CRC cis rs274567 0.501 rs581968 chr5:131710202 G/A cg07395648 chr5:131743802 NA 0.43 6.0 0.31 5.26e-9 Blood metabolite levels; CRC cis rs757110 0.745 rs2074311 chr11:17421860 A/G cg15432903 chr11:17409602 KCNJ11 0.55 7.45 0.38 8.12e-13 Type 2 diabetes; CRC cis rs6741819 0.956 rs4669126 chr2:7152120 T/C cg27144453 chr2:7172511 RNF144A -0.4 -5.93 -0.31 7.48e-9 Response to antipsychotic treatment; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg17064520 chr10:98591758 LCOR 0.4 6.47 0.34 3.56e-10 Liver disease severity in Alagille syndrome; CRC cis rs4663866 0.901 rs71426512 chr2:239187128 C/T cg16914508 chr2:239161102 PER2 0.74 7.99 0.4 2.26e-14 Irritable bowel syndrome; CRC cis rs4561483 0.619 rs12597429 chr16:12062396 A/G cg08843971 chr16:11963173 GSPT1 -0.45 -6.36 -0.33 6.59e-10 Testicular germ cell tumor; CRC cis rs730566 1.000 rs730566 chr3:48487048 G/T cg20833759 chr3:49053208 WDR6;DALRD3 -0.43 -6.27 -0.33 1.11e-9 Prion diseases; CRC cis rs826838 0.967 rs4768330 chr12:39129399 T/C cg13010199 chr12:38710504 ALG10B -0.41 -5.8 -0.3 1.59e-8 Heart rate; CRC cis rs10504229 1.000 rs56255635 chr8:58178264 T/C cg24829409 chr8:58192753 C8orf71 -0.68 -11.34 -0.53 2.27e-25 Developmental language disorder (linguistic errors); CRC cis rs9303401 1.000 rs6503877 chr17:56841948 C/T cg02118635 chr17:56770003 RAD51C;TEX14 0.55 8.13 0.41 9.05e-15 Cognitive test performance; CRC cis rs9322193 0.962 rs4870048 chr6:150155460 A/G cg05861140 chr6:150128134 PCMT1 -0.42 -6.85 -0.35 3.69e-11 Lung cancer; CRC cis rs2404602 0.735 rs437131 chr15:76781051 C/T cg23625390 chr15:77176239 SCAPER 0.77 11.99 0.55 1.01e-27 Blood metabolite levels; CRC cis rs7605827 1.000 rs7605827 chr2:15598740 A/T cg19274914 chr2:15703543 NA 0.39 5.96 0.31 6.58e-9 Educational attainment (years of education); CRC cis rs921968 0.643 rs485765 chr2:219480804 C/G cg02176678 chr2:219576539 TTLL4 0.41 6.56 0.34 2.07e-10 Mean corpuscular hemoglobin concentration; CRC cis rs7107174 1.000 rs2248407 chr11:77937800 G/A cg02023728 chr11:77925099 USP35 0.49 7.95 0.4 3.03e-14 Testicular germ cell tumor; CRC cis rs775227 0.574 rs35274817 chr3:113266391 A/G cg10517650 chr3:113235015 CCDC52 -0.39 -5.63 -0.3 3.88e-8 Dental caries; CRC trans rs8073060 0.544 rs2626626 chr17:34026717 A/G cg19694781 chr19:47549865 TMEM160 -1.08 -14.86 -0.63 1.46e-38 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; CRC cis rs1862618 0.613 rs252889 chr5:56227069 C/A cg12311346 chr5:56204834 C5orf35 -0.66 -9.73 -0.47 7.89e-20 Initial pursuit acceleration; CRC cis rs7481584 0.626 rs2071103 chr11:3040087 C/T cg25174290 chr11:3078921 CARS -0.4 -5.62 -0.3 4.05e-8 Calcium levels; CRC cis rs6942756 0.806 rs2718093 chr7:128939582 G/A cg02491457 chr7:128862824 NA -0.66 -9.2 -0.45 4.38e-18 White matter hyperintensity burden; CRC cis rs1799949 1.000 rs4534897 chr17:41431808 A/G cg25072359 chr17:41440525 NA 0.42 6.33 0.33 7.89e-10 Menopause (age at onset); CRC cis rs6502050 0.835 rs4641801 chr17:80154021 G/A cg02741985 chr17:80059408 CCDC57 0.43 7.17 0.37 4.94e-12 Life satisfaction; CRC cis rs854765 0.647 rs854769 chr17:18019011 A/G cg16928487 chr17:17741425 SREBF1 0.48 8.23 0.41 4.36e-15 Total body bone mineral density; CRC cis rs6912958 0.535 rs448580 chr6:88040399 A/C cg12350822 chr6:88032061 C6orf162;GJB7 0.51 10.29 0.49 1e-21 Monocyte percentage of white cells; CRC cis rs10504229 0.683 rs16921819 chr8:58107936 G/T cg24829409 chr8:58192753 C8orf71 -0.56 -8.01 -0.4 2.05e-14 Developmental language disorder (linguistic errors); CRC cis rs711245 0.545 rs848617 chr2:36811298 G/C cg09467607 chr2:36825704 FEZ2 0.5 8.2 0.41 5.29e-15 Height; CRC cis rs501120 0.525 rs1704229 chr10:44689529 G/A cg09554077 chr10:44749378 NA 0.57 7.99 0.4 2.25e-14 Coronary artery disease;Coronary heart disease; CRC cis rs775227 0.574 rs35274817 chr3:113266391 A/G cg18753928 chr3:113234510 CCDC52 -0.59 -7.06 -0.36 1e-11 Dental caries; CRC cis rs7647973 0.710 rs12637313 chr3:49645458 A/G cg13072238 chr3:49761600 GMPPB -0.52 -5.75 -0.3 2.05e-8 Menarche (age at onset); CRC cis rs13082711 0.911 rs6775176 chr3:27432475 G/A cg02860705 chr3:27208620 NA 0.61 8.77 0.44 9.58e-17 Systolic blood pressure;Diastolic blood pressure;Blood pressure; CRC cis rs6951245 1.000 rs77760339 chr7:1083927 G/T cg21664854 chr7:1097933 C7orf50;GPR146 0.79 8.94 0.44 2.89e-17 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs9549328 0.670 rs35992827 chr13:113616752 G/A cg20742385 chr13:113633654 MCF2L 0.53 8.95 0.44 2.61e-17 Systolic blood pressure; CRC cis rs908922 0.676 rs10888494 chr1:152514709 T/C cg23254163 chr1:152506842 NA 0.44 8.62 0.43 2.8e-16 Hair morphology; CRC cis rs10256972 0.591 rs11766651 chr7:1161646 A/G cg26608667 chr7:1196370 ZFAND2A 0.41 6.51 0.34 2.82e-10 Longevity;Endometriosis; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg25377726 chr2:45838438 SRBD1 0.42 6.26 0.33 1.22e-9 Intelligence (multi-trait analysis); CRC cis rs2075371 0.933 rs1421482 chr7:133964383 A/G cg20476274 chr7:133979776 SLC35B4 0.78 14.1 0.61 1.17e-35 Mean platelet volume; CRC cis rs1218582 0.774 rs11264284 chr1:154875793 C/T cg16680214 chr1:154839983 KCNN3 -0.48 -9.34 -0.46 1.52e-18 Prostate cancer; CRC cis rs2839186 0.771 rs13049175 chr21:47641326 G/A cg11766577 chr21:47581405 C21orf56 0.53 8.61 0.43 3.05e-16 Testicular germ cell tumor; CRC cis rs9462846 0.821 rs2092554 chr6:42863921 G/A cg21280719 chr6:42927975 GNMT -0.33 -6.49 -0.34 3.09e-10 Blood protein levels; CRC trans rs1945213 0.694 rs34828123 chr11:55837868 T/A cg03929089 chr4:120376271 NA 0.56 6.35 0.33 7.04e-10 Acute lymphoblastic leukemia (childhood); CRC cis rs1707322 0.964 rs10890358 chr1:46319025 T/A cg03146154 chr1:46216737 IPP 0.5 6.98 0.36 1.66e-11 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs16975963 0.644 rs2290999 chr19:38138887 T/C cg15135657 chr19:38346511 NA -0.44 -6.15 -0.32 2.21e-9 Longevity; CRC cis rs873946 0.586 rs61862838 chr10:134572282 C/T cg27286337 chr10:134555280 INPP5A 0.8 9.72 0.47 8.83e-20 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CRC cis rs7224737 1.000 rs2240009 chr17:40283142 C/G cg02450064 chr17:40260053 DHX58 -0.43 -6.24 -0.33 1.38e-9 Fibrinogen levels; CRC cis rs1799949 0.965 rs8176322 chr17:41195773 A/G cg23758822 chr17:41437982 NA 0.8 13.7 0.6 4.08e-34 Menopause (age at onset); CRC cis rs7824557 0.564 rs2736295 chr8:11234780 C/G cg08071915 chr8:12219732 FAM66A -0.34 -6.38 -0.33 5.98e-10 Retinal vascular caliber; CRC cis rs10504229 0.953 rs75253516 chr8:58171547 C/A cg01721255 chr8:58191610 C8orf71 0.53 6.6 0.34 1.69e-10 Developmental language disorder (linguistic errors); CRC cis rs17433780 0.808 rs12125301 chr1:89508501 G/A cg09516651 chr1:89888402 LOC400759 0.5 7.85 0.4 5.87e-14 Carotid intima media thickness; CRC cis rs6951245 1.000 rs28379681 chr7:1070539 C/T cg24642844 chr7:1081250 C7orf50 -0.78 -9.35 -0.46 1.42e-18 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs9303280 0.901 rs2305479 chr17:38062217 C/T cg17344932 chr17:38183730 MED24;SNORD124 0.37 5.9 0.31 9.05e-9 Self-reported allergy; CRC cis rs12188164 1.000 rs55842567 chr5:437586 G/A cg26850624 chr5:429559 AHRR -0.81 -13.83 -0.61 1.3e-34 Cystic fibrosis severity; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg14813019 chr8:90996956 NBN 0.42 6.07 0.32 3.5e-9 Intelligence (multi-trait analysis); CRC cis rs1552244 0.554 rs6800204 chr3:9995404 A/G cg16606324 chr3:10149918 C3orf24 0.45 6.82 0.35 4.25e-11 Alzheimer's disease; CRC trans rs853679 0.546 rs483143 chr6:27846744 G/C cg06606381 chr12:133084897 FBRSL1 -0.77 -6.64 -0.34 1.29e-10 Depression; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg07656362 chr1:32688117 C1orf91;EIF3I 0.48 6.58 0.34 1.88e-10 Response to antipsychotic treatment; CRC cis rs2276314 0.857 rs72883058 chr18:33612917 G/A cg19628046 chr18:33552617 C18orf21 0.5 6.73 0.35 7.54e-11 Endometriosis;Drug-induced torsades de pointes; CRC cis rs12580194 0.593 rs7487419 chr12:55769801 C/G cg23425280 chr12:56401806 NA 0.47 5.83 0.31 1.34e-8 Cancer; CRC cis rs7647973 0.961 rs62259943 chr3:49425167 A/G cg07636037 chr3:49044803 WDR6 -0.64 -7.39 -0.38 1.25e-12 Menarche (age at onset); CRC cis rs11209185 0.509 rs9326077 chr1:68452192 A/G cg22082780 chr1:68452167 NA 0.49 7.89 0.4 4.61e-14 Itch intensity from mosquito bite adjusted by bite size; CRC cis rs7172809 0.643 rs75334741 chr15:77841492 T/C cg10437265 chr15:77819839 NA -0.39 -6.6 -0.34 1.6e-10 Glucose homeostasis traits; CRC cis rs2276314 0.857 rs28530656 chr18:33588700 C/T cg19628046 chr18:33552617 C18orf21 -0.54 -7.08 -0.36 8.56e-12 Endometriosis;Drug-induced torsades de pointes; CRC cis rs9549260 0.753 rs9549254 chr13:41234763 G/A cg21288729 chr13:41239152 FOXO1 0.49 6.1 0.32 3.05e-9 Red blood cell count; CRC cis rs7666738 0.830 rs6832209 chr4:98994120 A/G cg05340658 chr4:99064831 C4orf37 0.58 8.94 0.44 2.79e-17 Colonoscopy-negative controls vs population controls; CRC cis rs1472147 0.955 rs3736611 chr7:128509243 C/G cg00260937 chr7:128520193 KCP 0.49 7.31 0.37 2.07e-12 Calcium levels; CRC cis rs2404602 0.740 rs34924128 chr15:76965169 T/G cg22467129 chr15:76604101 ETFA -0.39 -6.54 -0.34 2.4e-10 Blood metabolite levels; CRC cis rs992157 0.866 rs2292554 chr2:219146868 T/C cg13835894 chr2:219148914 PNKD;TMBIM1 -0.36 -6.78 -0.35 5.63e-11 Colorectal cancer; CRC cis rs7943191 0.810 rs7942154 chr11:62337163 G/A cg13298116 chr11:62369859 EML3;MTA2 0.58 9.23 0.45 3.49e-18 Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction); CRC trans rs9858542 0.903 rs11917431 chr3:49644012 C/T cg21659725 chr3:3221576 CRBN -0.7 -9.15 -0.45 6.25e-18 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs6424115 0.867 rs11588187 chr1:24145047 T/A cg15997130 chr1:24165203 NA 0.71 10.98 0.52 4.03e-24 Immature fraction of reticulocytes; CRC cis rs3743266 0.613 rs2414669 chr15:60708824 A/G cg21667061 chr15:60772094 NARG2 0.31 6.24 0.33 1.38e-9 Menarche (age at onset); CRC cis rs6500602 0.627 rs9938228 chr16:4530597 T/C cg06139259 chr16:4526053 HMOX2;NMRAL1 0.55 7.21 0.37 3.98e-12 Schizophrenia; CRC cis rs875971 0.965 rs10267430 chr7:65743023 G/T cg18876405 chr7:65276391 NA -0.52 -8.9 -0.44 3.88e-17 Aortic root size; CRC cis rs9303401 0.527 rs12946522 chr17:56768103 A/C cg10487724 chr17:56770010 TEX14;RAD51C 0.72 8.61 0.43 3.05e-16 Cognitive test performance; CRC cis rs1580019 0.713 rs2122632 chr7:32524686 A/G cg06627557 chr7:32535165 LSM5;AVL9 -0.98 -17.81 -0.7 3.7e-50 Cognitive ability; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg25341789 chr19:3506185 FZR1 0.45 6.2 0.32 1.7e-9 Response to antipsychotic treatment; CRC cis rs4731207 0.596 rs719972 chr7:124631797 G/A cg23710748 chr7:124431027 NA -0.39 -6.17 -0.32 2.06e-9 Cutaneous malignant melanoma; CRC cis rs72615157 0.645 rs76281814 chr7:99846414 T/C cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.48 5.65 0.3 3.57e-8 Lung function (FEV1/FVC); CRC cis rs367943 0.965 rs644154 chr5:112799080 G/T cg12552261 chr5:112820674 MCC -0.49 -7.74 -0.39 1.25e-13 Type 2 diabetes; CRC cis rs79839061 0.656 rs11726912 chr4:887868 A/C cg07828340 chr4:882639 GAK 1.13 11.6 0.54 2.58e-26 Intelligence (multi-trait analysis); CRC cis rs1580019 0.961 rs11765387 chr7:32494790 T/C cg06627557 chr7:32535165 LSM5;AVL9 0.71 11.2 0.53 6.71e-25 Cognitive ability; CRC cis rs79349575 0.783 rs58591767 chr17:47026076 G/A cg00947319 chr17:47005597 UBE2Z -0.33 -5.67 -0.3 3.19e-8 Type 2 diabetes; CRC cis rs2230307 0.656 rs1395332 chr1:100503993 A/C cg24955406 chr1:100503596 HIAT1 0.61 7.32 0.37 1.88e-12 Carotid intima media thickness; CRC cis rs909002 0.800 rs3753612 chr1:32082410 C/G cg13919466 chr1:32135498 COL16A1 -0.3 -5.73 -0.3 2.27e-8 Intelligence (multi-trait analysis); CRC cis rs12760731 0.720 rs12039605 chr1:178433368 C/T cg00404053 chr1:178313656 RASAL2 0.95 9.93 0.48 1.66e-20 Obesity-related traits; CRC cis rs6693567 0.545 rs1932934 chr1:150449195 G/A cg15654264 chr1:150340011 RPRD2 0.37 5.64 0.3 3.71e-8 Migraine; CRC cis rs1045714 0.895 rs4719594 chr7:2639790 G/A cg24848437 chr7:2645542 IQCE 0.58 6.02 0.32 4.54e-9 Urate levels in lean individuals; CRC cis rs6557786 0.636 rs17052934 chr8:24840319 A/C cg27411370 chr8:25316735 KCTD9;CDCA2 0.5 6.75 0.35 6.61e-11 Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 2 peripheral neuropathy); CRC cis rs911555 0.673 rs7144271 chr14:103890674 A/G cg12935359 chr14:103987150 CKB -0.57 -9.2 -0.45 4.14e-18 Intelligence (multi-trait analysis); CRC cis rs875971 0.660 rs801211 chr7:66015689 T/G cg18876405 chr7:65276391 NA -0.61 -10.95 -0.52 5.42e-24 Aortic root size; CRC cis rs9926296 0.565 rs8055825 chr16:89832848 C/T cg27121462 chr16:89883253 FANCA 0.56 8.78 0.44 9.18e-17 Vitiligo; CRC cis rs3736485 0.966 rs11070855 chr15:51850283 C/T cg08986416 chr15:51914746 DMXL2 -0.45 -6.6 -0.34 1.65e-10 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs12887734 0.566 rs8548 chr14:104199580 A/C cg01849466 chr14:104193079 ZFYVE21 -0.46 -6.92 -0.36 2.41e-11 Schizophrenia;Autism spectrum disorder or schizophrenia; CRC cis rs6499129 0.867 rs7196853 chr16:67560613 T/C cg26727032 chr16:67993705 SLC12A4 -0.64 -7.72 -0.39 1.43e-13 Waist-to-hip ratio adjusted for body mass index; CRC cis rs4975616 0.804 rs459961 chr5:1337106 T/A cg06550200 chr5:1325588 CLPTM1L -0.76 -12.47 -0.57 1.71e-29 Lung cancer; CRC cis rs9814567 1.000 rs6763088 chr3:134254989 C/G cg06109529 chr3:134205091 CEP63;ANAPC13 0.82 12.06 0.55 5.69e-28 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs10504229 0.683 rs55807014 chr8:58131801 T/C cg21724239 chr8:58056113 NA 0.49 6.81 0.35 4.75e-11 Developmental language disorder (linguistic errors); CRC cis rs478304 0.580 rs11606947 chr11:65508237 A/C cg27068330 chr11:65405492 SIPA1 -0.67 -10.14 -0.49 3.2e-21 Acne (severe); CRC cis rs6088580 0.634 rs6059892 chr20:33105766 A/G cg24642439 chr20:33292090 TP53INP2 0.39 6.59 0.34 1.73e-10 Glomerular filtration rate (creatinine); CRC cis rs754466 0.651 rs11002316 chr10:79617511 C/G cg26805224 chr10:79626177 DLG5 -0.56 -8.34 -0.42 2.12e-15 Liver enzyme levels (gamma-glutamyl transferase); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg06231882 chr16:81040594 CENPN;C16orf61 0.46 6.51 0.34 2.82e-10 Response to antipsychotic treatment; CRC cis rs12580194 0.593 rs61956275 chr12:55786423 G/A cg19537932 chr12:55886519 OR6C68 -0.72 -9.08 -0.45 9.94e-18 Cancer; CRC cis rs921968 0.565 rs6436081 chr2:219637884 A/G cg02176678 chr2:219576539 TTLL4 -0.45 -7.08 -0.36 8.77e-12 Mean corpuscular hemoglobin concentration; CRC cis rs9549367 1.000 rs9549367 chr13:113911532 C/G cg00898013 chr13:113819073 PROZ -0.43 -6.18 -0.32 1.93e-9 Platelet distribution width; CRC cis rs4900538 0.819 rs72698591 chr14:102838896 G/A cg18135206 chr14:102964638 TECPR2 -0.98 -17.27 -0.69 5.1e-48 Mean corpuscular volume;Mean corpuscular hemoglobin; CRC cis rs13191362 0.935 rs34934114 chr6:163082480 G/A cg14584255 chr6:163149320 PACRG;PARK2 0.43 6.14 0.32 2.38e-9 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC trans rs4332037 0.851 rs73050128 chr7:1961882 C/A cg11693508 chr17:37793320 STARD3 0.68 8.13 0.41 8.87e-15 Bipolar disorder; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg09241033 chr17:7893344 NA 0.46 6.33 0.33 8.14e-10 Anxiety disorder; CRC cis rs832540 0.629 rs6888317 chr5:56093307 A/G cg24531977 chr5:56204891 C5orf35 0.53 8.01 0.4 2.06e-14 Coronary artery disease; CRC cis rs1799949 1.000 rs4793191 chr17:41204377 A/G cg23758822 chr17:41437982 NA 0.8 13.69 0.6 4.46e-34 Menopause (age at onset); CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg17487170 chr5:133451259 TCF7 0.37 6.39 0.33 5.61e-10 Obesity-related traits; CRC cis rs10791097 0.967 rs4366492 chr11:130717256 T/C cg12179176 chr11:130786555 SNX19 0.61 9.4 0.46 9.75e-19 Autism spectrum disorder or schizophrenia;Schizophrenia; CRC cis rs7811142 1.000 rs7803454 chr7:99991548 C/T cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.16 15.3 0.64 2.86e-40 Platelet count; CRC trans rs1656966 1.000 rs1656966 chr3:186466252 C/T cg21715088 chr18:74534568 NA 0.39 6.0 0.31 5.18e-9 Myopia (pathological); CRC cis rs9814567 0.752 rs7649910 chr3:134241310 A/T cg06109529 chr3:134205091 CEP63;ANAPC13 -0.81 -12.36 -0.56 4.47e-29 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs1218582 0.804 rs4845398 chr1:154859038 G/C cg09359103 chr1:154839909 KCNN3 -0.73 -12.91 -0.58 3.88e-31 Prostate cancer; CRC cis rs6570726 0.791 rs427128 chr6:145865917 T/C cg05347473 chr6:146136440 FBXO30 0.39 5.89 0.31 9.68e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs9517320 0.967 rs9517317 chr13:99125711 G/C cg20487152 chr13:99095054 FARP1 0.35 5.85 0.31 1.21e-8 Longevity; CRC cis rs6543140 0.964 rs10200081 chr2:103091556 T/C cg03938978 chr2:103052716 IL18RAP 0.42 6.65 0.34 1.19e-10 Blood protein levels; CRC cis rs763014 0.966 rs7185390 chr16:666382 A/G cg09263875 chr16:632152 PIGQ 0.76 11.99 0.55 9.8e-28 Height; CRC cis rs7412746 0.611 rs11803940 chr1:150685835 A/G cg15448220 chr1:150897856 SETDB1 0.47 6.76 0.35 6.44e-11 Melanoma; CRC trans rs3942852 0.915 rs905477 chr11:48148606 T/C cg15704280 chr7:45808275 SEPT13 -0.65 -7.95 -0.4 2.98e-14 Acute lymphoblastic leukemia (childhood); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg05181282 chr17:2496653 PAFAH1B1 0.41 5.97 0.31 6.12e-9 Intelligence (multi-trait analysis); CRC cis rs2228479 0.850 rs62054640 chr16:89823157 C/T cg06656553 chr16:89960601 TCF25 -0.7 -5.76 -0.3 1.93e-8 Skin colour saturation; CRC cis rs6499255 1.000 rs7189424 chr16:69782746 G/A cg00738113 chr16:70207722 CLEC18C -0.41 -5.92 -0.31 7.99e-9 IgE levels; CRC cis rs1552244 1.000 rs12152512 chr3:10143770 C/T cg00166722 chr3:10149974 C3orf24 0.63 8.8 0.44 7.68e-17 Alzheimer's disease; CRC cis rs10464366 0.517 rs13231075 chr7:39174806 G/T cg18850127 chr7:39170497 POU6F2 0.57 7.56 0.38 4e-13 IgG glycosylation; CRC trans rs208520 1.000 rs72882100 chr6:66981495 G/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.88 10.81 0.51 1.63e-23 Exhaled nitric oxide output; CRC cis rs892961 0.931 rs2411110 chr17:75400143 A/C cg05865280 chr17:75406074 SEPT9 0.51 8.11 0.41 1.04e-14 Airflow obstruction; CRC cis rs57221529 0.825 rs7443550 chr5:578404 G/T cg14541582 chr5:601475 NA -0.37 -7.13 -0.37 6.35e-12 Lung disease severity in cystic fibrosis; CRC cis rs3806843 0.900 rs116210441 chr5:140128649 T/A cg16607685 chr5:140181889 PCDHA2;PCDHA1;PCDHA3 0.26 5.96 0.31 6.61e-9 Depressive symptoms (multi-trait analysis); CRC cis rs10504229 1.000 rs57186557 chr8:58177277 A/G cg22535103 chr8:58192502 C8orf71 -0.82 -12.27 -0.56 9.63e-29 Developmental language disorder (linguistic errors); CRC trans rs9956878 0.555 rs8085188 chr18:73544676 A/G cg14671666 chr5:41904456 C5orf51 -0.37 -6.01 -0.31 4.96e-9 Obesity-related traits; CRC cis rs2276314 0.857 rs62101379 chr18:33584902 G/A cg19628046 chr18:33552617 C18orf21 0.56 7.41 0.38 1.07e-12 Endometriosis;Drug-induced torsades de pointes; CRC cis rs11758351 0.660 rs2143345 chr6:26229148 C/T cg22723502 chr6:26240528 HIST1H4F -0.37 -6.11 -0.32 2.87e-9 Gout;Renal underexcretion gout; CRC cis rs8177253 0.634 rs6798547 chr3:133448499 G/A cg17775713 chr3:133465469 TF 0.34 5.9 0.31 9.24e-9 Iron status biomarkers; CRC cis rs7927771 0.864 rs755553 chr11:47432303 G/A cg18512352 chr11:47633146 NA 0.36 7.07 0.36 9.23e-12 Subjective well-being; CRC cis rs2625529 0.730 rs3759900 chr15:72451827 A/C cg16672083 chr15:72433130 SENP8 0.45 6.64 0.34 1.28e-10 Red blood cell count; CRC cis rs9818758 0.607 rs11552724 chr3:49156473 C/G cg00383909 chr3:49044727 WDR6 1.26 12.25 0.56 1.14e-28 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; CRC cis rs41271473 0.500 rs10916366 chr1:228894575 T/C cg00850481 chr1:228891306 NA -0.44 -6.83 -0.35 4.01e-11 Chronic lymphocytic leukemia; CRC cis rs7949030 0.626 rs11231154 chr11:62362293 A/G cg22862634 chr11:62369728 EML3;MTA2 0.57 9.96 0.48 1.32e-20 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; CRC cis rs12477438 0.798 rs4850894 chr2:99629396 A/T cg26064155 chr2:99771622 LIPT1;TSGA10 -0.79 -11.26 -0.53 4.29e-25 Chronic sinus infection; CRC cis rs4509693 1.000 rs4277047 chr10:102499416 T/A cg23167259 chr10:102495509 NA -0.49 -6.83 -0.35 4.04e-11 Alzheimer's disease; CRC trans rs1455244 0.700 rs7229302 chr18:11508904 G/T cg18604133 chr13:27746144 USP12 0.38 6.05 0.32 4e-9 Schizophrenia; CRC trans rs875971 0.660 rs2191268 chr7:66110224 C/T cg16672449 chr3:127842622 RUVBL1 -0.41 -6.39 -0.33 5.51e-10 Aortic root size; CRC cis rs4588572 0.561 rs12697887 chr5:77804729 A/G cg11547950 chr5:77652471 NA -0.43 -6.18 -0.32 1.87e-9 Triglycerides; CRC cis rs236352 0.576 rs3778017 chr6:36842183 C/T cg10099585 chr6:36853529 C6orf89 -0.45 -6.34 -0.33 7.47e-10 Heart rate; CRC cis rs9326248 0.954 rs10790177 chr11:117048417 A/G cg26566898 chr11:117069891 TAGLN 0.44 9.77 0.47 5.91e-20 Blood protein levels; CRC cis rs9768139 0.935 rs116290351 chr7:158119712 T/A cg23298862 chr7:158159286 PTPRN2 -0.47 -7.64 -0.39 2.47e-13 Calcium levels; CRC cis rs932541 0.955 rs6034488 chr20:16456611 G/A cg17003395 chr20:16555519 KIF16B 0.41 5.63 0.3 3.82e-8 Intelligence; CRC cis rs7524258 0.900 rs7551574 chr1:7314363 G/T cg07173049 chr1:7289937 CAMTA1 0.52 8.45 0.42 9.3e-16 Tourette's syndrome or obsessive-compulsive disorder; CRC cis rs2180341 0.814 rs9401958 chr6:127736357 T/G cg27446573 chr6:127587934 RNF146 0.7 9.61 0.47 1.95e-19 Breast cancer; CRC cis rs1568889 0.838 rs11030206 chr11:28099747 C/T cg06544937 chr11:28130018 METT5D1;KIF18A 0.9 15.13 0.64 1.23e-39 Bipolar disorder; CRC trans rs10506458 1.000 rs12425655 chr12:63434463 C/T cg22491629 chr6:157744540 C6orf35 -0.65 -8.27 -0.41 3.45e-15 Hemostatic factors and hematological phenotypes; CRC trans rs10982213 0.830 rs2274163 chr9:117188714 C/T cg25660386 chr3:13009126 IQSEC1 0.39 6.11 0.32 2.83e-9 Interleukin-6 levels; CRC cis rs13031619 0.650 rs6542617 chr2:3694932 C/T cg00999904 chr2:3704751 ALLC 0.41 5.76 0.3 1.93e-8 Response to inhaled corticosteroid treatment in asthma (change in FEV1); CRC cis rs6723226 0.650 rs6729952 chr2:32764922 T/C cg02381751 chr2:32503542 YIPF4 0.51 7.49 0.38 6.31e-13 Intelligence (multi-trait analysis); CRC cis rs8058578 0.945 rs8058961 chr16:30809063 G/A cg02466173 chr16:30829666 NA -0.87 -13.64 -0.6 7.1e-34 Multiple myeloma; CRC cis rs798554 0.683 rs1182155 chr7:2902890 C/G cg13628971 chr7:2884303 GNA12 0.5 7.15 0.37 5.71e-12 Height; CRC cis rs7680126 0.500 rs4697717 chr4:10149784 C/G cg00071950 chr4:10020882 SLC2A9 -0.48 -6.13 -0.32 2.55e-9 Urate levels in lean individuals;Urate levels in overweight individuals;Urate levels in obese individuals; CRC cis rs2108225 0.872 rs2051955 chr7:107441154 C/T cg18560240 chr7:107437656 SLC26A3 -0.63 -9.5 -0.46 4.54e-19 Ulcerative colitis; CRC cis rs10971721 0.731 rs72727303 chr9:33878376 G/T cg13495928 chr9:33750294 PRSS3 0.56 5.95 0.31 6.96e-9 Body mass index; CRC trans rs7395662 0.963 rs61930968 chr11:48581649 C/T cg21153622 chr11:89784906 NA -0.46 -7.31 -0.37 2.06e-12 HDL cholesterol; CRC cis rs55692411 0.537 rs7648652 chr3:50135412 A/C cg24110177 chr3:50126178 RBM5 -0.49 -5.82 -0.31 1.4e-8 Intelligence (multi-trait analysis); CRC cis rs644148 0.803 rs2686771 chr19:44999494 T/C cg15540054 chr19:45004280 ZNF180 -0.58 -8.19 -0.41 6e-15 Personality dimensions; CRC cis rs873946 0.648 rs12769533 chr10:134548685 C/T cg06453172 chr10:134556979 INPP5A 0.69 8.73 0.43 1.31e-16 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CRC cis rs1552244 0.554 rs6443275 chr3:10008819 G/A cg00166722 chr3:10149974 C3orf24 0.43 6.47 0.34 3.6e-10 Alzheimer's disease; CRC trans rs1814175 0.645 rs11040661 chr11:49952146 G/T cg21153622 chr11:89784906 NA -0.39 -6.08 -0.32 3.33e-9 Height; CRC cis rs4713118 0.868 rs2893928 chr6:27738430 C/A cg15845792 chr6:28175446 NA 0.74 7.97 0.4 2.64e-14 Parkinson's disease; CRC cis rs896854 0.936 rs10108430 chr8:95961794 C/T cg09323728 chr8:95962352 TP53INP1 -0.42 -6.85 -0.35 3.68e-11 Type 2 diabetes; CRC cis rs644799 0.932 rs572015 chr11:95637416 T/A cg25478527 chr11:95522999 CEP57;FAM76B 0.5 7.41 0.38 1.1e-12 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs10883723 0.810 rs7093028 chr10:104259417 A/G cg11453585 chr10:104263688 ACTR1A;SUFU 0.92 17.58 0.7 2.89e-49 Allergic disease (asthma, hay fever or eczema); CRC cis rs7937682 0.889 rs559482 chr11:111497902 G/A cg19812747 chr11:111475976 SIK2 -0.57 -9.66 -0.47 1.38e-19 Primary sclerosing cholangitis; CRC cis rs12908161 0.960 rs62019463 chr15:85288087 G/A cg17507749 chr15:85114479 UBE2QP1 0.63 9.24 0.45 3.07e-18 Schizophrenia; CRC cis rs875971 1.000 rs12532998 chr7:65967459 A/C cg11764359 chr7:65958608 NA 0.63 10.27 0.49 1.21e-21 Aortic root size; CRC cis rs12711979 1.000 rs6542655 chr2:3872434 T/C cg17052675 chr2:3827356 NA -0.52 -9.41 -0.46 8.91e-19 Itch intensity from mosquito bite adjusted by bite size; CRC trans rs637571 0.522 rs556643 chr11:65733289 C/T cg17712092 chr4:129076599 LARP1B 0.63 10.35 0.5 6.65e-22 Eosinophil percentage of white cells; CRC cis rs2836950 0.545 rs8132424 chr21:40584412 A/T cg11890956 chr21:40555474 PSMG1 0.68 10.24 0.49 1.49e-21 Menarche (age at onset); CRC cis rs7927592 0.731 rs11228275 chr11:68303980 G/A cg16797656 chr11:68205561 LRP5 -0.45 -8.27 -0.41 3.44e-15 Total body bone mineral density; CRC trans rs3931020 0.720 rs927904 chr1:75260328 A/G cg00843398 chr6:24403479 MRS2 0.48 6.13 0.32 2.47e-9 Resistin levels; CRC cis rs2985684 0.894 rs8005990 chr14:50022248 G/A cg04989706 chr14:50066350 PPIL5 -0.6 -8.44 -0.42 1.05e-15 Carotid intima media thickness; CRC cis rs7618915 0.501 rs12635140 chr3:52738165 C/T cg11645453 chr3:52864694 ITIH4 -0.36 -6.48 -0.34 3.45e-10 Bipolar disorder; CRC cis rs7849270 0.921 rs7868476 chr9:131918133 A/G cg13538475 chr9:131942899 NA -0.34 -6.34 -0.33 7.58e-10 Blood metabolite ratios; CRC cis rs1046896 1.000 rs1046917 chr17:80685655 A/G cg16060761 chr17:80687452 NA 0.53 8.12 0.41 9.73e-15 Glycated hemoglobin levels; CRC cis rs629535 0.773 rs568159 chr8:70032908 C/G cg26132723 chr8:70041827 NA 0.35 5.72 0.3 2.41e-8 Dupuytren's disease; CRC cis rs9487051 0.676 rs1829694 chr6:109593860 G/T cg01475377 chr6:109611718 NA -0.37 -6.58 -0.34 1.85e-10 Reticulocyte fraction of red cells; CRC cis rs9463078 0.507 rs1023089 chr6:45012346 G/A cg25276700 chr6:44698697 NA 0.24 5.67 0.3 3.13e-8 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; CRC cis rs4665809 0.590 rs6716858 chr2:26423414 G/A cg08067268 chr2:26466485 HADHB;HADHA -0.52 -6.96 -0.36 1.86e-11 Gut microbiome composition (summer); CRC cis rs17270561 0.609 rs9348695 chr6:25763010 A/T cg17691542 chr6:26056736 HIST1H1C 0.64 8.14 0.41 8.02e-15 Iron status biomarkers; CRC cis rs8072100 0.840 rs12452796 chr17:45479733 G/T cg25173405 chr17:45401733 C17orf57 0.47 7.54 0.38 4.53e-13 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs6461049 0.519 rs3778992 chr7:2175313 C/G cg21782813 chr7:2030301 MAD1L1 0.38 7.09 0.36 8.15e-12 Schizophrenia; CRC cis rs6502050 0.835 rs10163482 chr17:80110394 C/A cg19223190 chr17:80058835 NA 0.4 6.36 0.33 6.88e-10 Life satisfaction; CRC cis rs10078 0.515 rs2672739 chr5:443447 A/C cg26072250 chr5:443457 EXOC3;C5orf55 0.59 6.11 0.32 2.74e-9 Fat distribution (HIV); CRC cis rs727479 0.523 rs700518 chr15:51529112 C/T cg19946085 chr15:51559439 CYP19A1 0.29 5.74 0.3 2.17e-8 Estradiol levels; CRC cis rs67311347 0.910 rs7651204 chr3:40512835 C/T cg24209194 chr3:40518798 ZNF619 -0.43 -6.24 -0.33 1.33e-9 Renal cell carcinoma; CRC cis rs7727544 0.716 rs72793278 chr5:131561372 C/A cg22638593 chr5:131593259 PDLIM4 0.35 6.43 0.33 4.46e-10 Blood metabolite levels; CRC cis rs6694672 0.867 rs1115247 chr1:197037667 A/G cg13682187 chr1:196946512 CFHR5 0.49 7.62 0.39 2.79e-13 Asthma; CRC cis rs1975974 0.872 rs17052352 chr17:21721972 A/G cg18423549 chr17:21743878 NA -0.56 -8.32 -0.42 2.39e-15 Psoriasis; CRC trans rs2710642 0.566 rs2710651 chr2:63166379 G/A cg05376469 chr2:102649931 NA -0.37 -6.23 -0.32 1.42e-9 LDL cholesterol levels;LDL cholesterol; CRC cis rs1448094 0.967 rs2121892 chr12:86324556 G/T cg02569458 chr12:86230093 RASSF9 0.37 6.47 0.34 3.47e-10 Major depressive disorder; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg20430870 chr10:52487619 NA -0.42 -6.87 -0.35 3.25e-11 Liver disease severity in Alagille syndrome; CRC cis rs11764590 0.715 rs62444907 chr7:2083267 C/T cg02421172 chr7:1938701 MAD1L1 0.47 6.25 0.33 1.3e-9 Neuroticism; CRC cis rs4713118 0.662 rs13218430 chr6:28029837 T/C cg18032046 chr6:28092343 ZSCAN16 -0.5 -6.33 -0.33 7.89e-10 Parkinson's disease; CRC cis rs9814567 0.806 rs6799543 chr3:134216139 G/T cg06541857 chr3:134203789 ANAPC13;CEP63 -0.39 -5.78 -0.3 1.73e-8 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs2952156 0.876 rs2313171 chr17:37833842 T/C cg00129232 chr17:37814104 STARD3 -0.68 -12.01 -0.55 8.36e-28 Asthma; CRC cis rs875971 0.545 rs1638724 chr7:66040481 A/G cg03233332 chr7:66118400 NA 0.44 6.08 0.32 3.42e-9 Aortic root size; CRC cis rs3741151 0.773 rs7945825 chr11:73287140 G/C cg17517138 chr11:73019481 ARHGEF17 0.96 7.46 0.38 8.01e-13 GIP levels in response to oral glucose tolerance test (120 minutes); CRC cis rs7085104 0.513 rs192569 chr10:104577915 T/C cg11453585 chr10:104263688 ACTR1A;SUFU 0.43 6.05 0.32 3.97e-9 Immature fraction of reticulocytes;Schizophrenia; CRC cis rs2880765 0.835 rs2170736 chr15:86043398 A/G cg17133734 chr15:86042851 AKAP13 0.42 6.72 0.35 7.92e-11 Coronary artery disease; CRC cis rs17125944 0.615 rs7150808 chr14:53304871 C/T cg00686598 chr14:53173677 PSMC6 -0.62 -5.76 -0.3 1.94e-8 Alzheimer's disease (late onset); CRC trans rs11148252 0.744 rs4884354 chr13:53017474 T/C cg18335740 chr13:41363409 SLC25A15 0.54 8.15 0.41 7.69e-15 Lewy body disease; CRC cis rs6831352 0.918 rs13143133 chr4:100054970 A/G cg12011299 chr4:100065546 ADH4 -0.49 -9.27 -0.45 2.61e-18 Alcohol dependence; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg03074839 chr11:107436493 ALKBH8 0.4 6.4 0.33 5.38e-10 Liver disease severity in Alagille syndrome; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg24992181 chr8:110657174 GOLSYN 0.38 6.11 0.32 2.84e-9 Liver disease severity in Alagille syndrome; CRC trans rs2303319 0.504 rs1006427 chr2:162592328 T/C cg22902534 chr3:183892754 AP2M1 -0.7 -6.1 -0.32 2.96e-9 Cognitive function; CRC cis rs360798 0.532 rs2136737 chr2:62969310 G/C cg17519650 chr2:63277830 OTX1 -0.45 -6.25 -0.33 1.27e-9 Coronary artery disease; CRC cis rs6502050 0.835 rs66531647 chr17:80089022 G/T cg19223190 chr17:80058835 NA 0.39 6.16 0.32 2.12e-9 Life satisfaction; CRC cis rs2996428 0.667 rs10492942 chr1:3764216 C/T cg13057898 chr1:3703894 LRRC47 0.55 7.3 0.37 2.21e-12 Red cell distribution width; CRC cis rs10504229 0.683 rs55807014 chr8:58131801 T/C cg02290350 chr8:58132656 NA -0.58 -8.16 -0.41 7.29e-15 Developmental language disorder (linguistic errors); CRC cis rs10504229 0.639 rs56825757 chr8:58106469 A/G cg22535103 chr8:58192502 C8orf71 -0.69 -8.8 -0.44 7.79e-17 Developmental language disorder (linguistic errors); CRC cis rs1008375 1.000 rs10032326 chr4:17630717 A/T cg16339924 chr4:17578868 LAP3 0.53 7.08 0.36 8.52e-12 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs4713118 0.597 rs172166 chr6:28020820 C/G cg02683197 chr6:28174875 NA 0.73 9.78 0.47 5.29e-20 Parkinson's disease; CRC cis rs2180341 1.000 rs3798850 chr6:127613966 C/T cg24812749 chr6:127587940 RNF146 0.94 13.67 0.6 5.36e-34 Breast cancer; CRC cis rs4474465 0.688 rs7945812 chr11:78280509 T/C cg27205649 chr11:78285834 NARS2 0.54 7.1 0.36 7.95e-12 Alzheimer's disease (survival time); CRC cis rs9322193 0.887 rs9767113 chr6:150039293 T/C cg07701084 chr6:150067640 NUP43 0.55 7.65 0.39 2.28e-13 Lung cancer; CRC cis rs473651 0.967 rs483042 chr2:239335320 A/G cg08773314 chr2:239334832 ASB1 0.38 8.81 0.44 7.56e-17 Multiple system atrophy; CRC cis rs908922 0.627 rs11590073 chr1:152500810 C/T cg09873164 chr1:152488093 CRCT1 0.37 6.1 0.32 2.98e-9 Hair morphology; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg15353389 chr12:120525027 CCDC64 0.5 7.08 0.36 8.92e-12 Response to antipsychotic treatment; CRC cis rs11059919 1 rs11059919 chr12:129289190 G/A cg09035930 chr12:129282057 SLC15A4 0.55 9.29 0.46 2.14e-18 Systemic lupus erythematosus; CRC cis rs59918340 0.764 rs4961338 chr8:142230192 C/T cg23750338 chr8:142222470 SLC45A4 -0.62 -11.75 -0.54 7.27e-27 Immature fraction of reticulocytes; CRC cis rs71403859 0.502 rs8051974 chr16:71488771 C/T cg08717414 chr16:71523259 ZNF19 -0.84 -9.2 -0.45 4.32e-18 Post bronchodilator FEV1; CRC cis rs8072100 0.840 rs9900360 chr17:45491979 C/T cg25173405 chr17:45401733 C17orf57 -0.48 -7.58 -0.39 3.52e-13 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs7512552 0.839 rs1625468 chr1:150321486 G/A cg15654264 chr1:150340011 RPRD2 0.58 8.1 0.41 1.08e-14 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); CRC cis rs6952808 0.929 rs12667688 chr7:1931030 C/T cg22963979 chr7:1858916 MAD1L1 -0.52 -7.66 -0.39 2.16e-13 Bipolar disorder and schizophrenia; CRC cis rs561341 0.660 rs7406043 chr17:30220152 C/G cg00745463 chr17:30367425 LRRC37B -0.71 -8.02 -0.4 1.84e-14 Hip circumference adjusted for BMI; CRC cis rs10504229 0.861 rs6990617 chr8:58182960 G/T cg05313129 chr8:58192883 C8orf71 -0.47 -6.99 -0.36 1.49e-11 Developmental language disorder (linguistic errors); CRC trans rs9929218 1.000 rs13333528 chr16:68790502 C/T cg04657470 chr2:198365150 HSPE1;HSPD1 -0.94 -13.32 -0.59 1.14e-32 Colorectal cancer; CRC cis rs589448 1.000 rs589448 chr12:69752200 A/G cg14784868 chr12:69753453 YEATS4 0.91 17.35 0.69 2.44e-48 Cerebrospinal fluid biomarker levels; CRC cis rs4423214 0.650 rs7940244 chr11:71221574 C/T cg05163923 chr11:71159392 DHCR7 -0.53 -6.76 -0.35 6.26e-11 Vitamin D levels; CRC cis rs7666738 0.830 rs13133619 chr4:99067312 C/G cg05340658 chr4:99064831 C4orf37 -0.6 -9.54 -0.47 3.39e-19 Colonoscopy-negative controls vs population controls; CRC trans rs7829975 0.688 rs7827182 chr8:8380471 C/G cg16141378 chr3:129829833 LOC729375 -0.47 -7.29 -0.37 2.27e-12 Mood instability; CRC cis rs4481887 1.000 rs10888356 chr1:248465044 C/T cg13385794 chr1:248469461 NA -0.38 -6.77 -0.35 5.83e-11 Common traits (Other); CRC cis rs10464366 0.544 rs9639812 chr7:39192058 C/T cg15212455 chr7:39170539 POU6F2 0.5 6.44 0.33 4.22e-10 IgG glycosylation; CRC cis rs873946 0.564 rs12772704 chr10:134557318 G/A cg27286337 chr10:134555280 INPP5A 0.85 10.26 0.49 1.29e-21 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CRC cis rs912057 1.000 rs912056 chr6:6736197 A/T cg06612196 chr6:6737390 NA 0.57 8.97 0.44 2.23e-17 Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction); CRC cis rs3820928 0.904 rs60906902 chr2:227760034 C/T cg11843606 chr2:227700838 RHBDD1 -0.41 -5.93 -0.31 7.62e-9 Pulmonary function; CRC cis rs17401966 0.540 rs6682868 chr1:10454773 C/T cg19773385 chr1:10388646 KIF1B 0.47 7.44 0.38 9.07e-13 Hepatocellular carcinoma; CRC cis rs7589728 0.844 rs2363010 chr2:88496399 G/C cg04511125 chr2:88470314 THNSL2 0.74 7.27 0.37 2.58e-12 Plasma clusterin levels; CRC cis rs1401999 1.000 rs6443927 chr3:183718864 A/G cg20387954 chr3:183756860 HTR3D 0.46 7.93 0.4 3.43e-14 Anterior chamber depth; CRC cis rs1005277 0.579 rs2474575 chr10:38387901 C/T cg00409905 chr10:38381863 ZNF37A -0.68 -11.32 -0.53 2.64e-25 Extrinsic epigenetic age acceleration; CRC cis rs13108904 0.901 rs1680073 chr4:1280337 G/A cg24560729 chr4:1342394 KIAA1530 -0.34 -6.25 -0.33 1.25e-9 Obesity-related traits; CRC cis rs7647973 0.731 rs7617480 chr3:49210732 G/T cg07690219 chr3:49449608 TCTA;RHOA 0.54 6.31 0.33 8.85e-10 Menarche (age at onset); CRC cis rs9399135 0.967 rs952674 chr6:135349157 A/G cg22676075 chr6:135203613 NA 0.4 6.25 0.33 1.27e-9 Red blood cell count; CRC cis rs3106136 0.527 rs4693376 chr4:95157240 A/G cg11021082 chr4:95130006 SMARCAD1 -0.51 -7.56 -0.38 4.12e-13 Capecitabine sensitivity; CRC cis rs875971 0.522 rs4502988 chr7:65297746 A/G cg05627663 chr7:65219948 SNORA22;CCT6P1 0.49 7.23 0.37 3.4e-12 Aortic root size; CRC trans rs2303319 0.504 rs62189053 chr2:162624324 G/A cg14875682 chr5:52083620 ITGA1;PELO -0.73 -6.12 -0.32 2.59e-9 Cognitive function; CRC cis rs7580658 0.963 rs4233584 chr2:128060163 C/T cg09760422 chr2:128146352 NA -0.37 -7.24 -0.37 3.17e-12 Protein C levels; CRC cis rs2153535 0.580 rs1889715 chr6:8443475 G/A cg21535247 chr6:8435926 SLC35B3 0.48 7.3 0.37 2.21e-12 Motion sickness; CRC cis rs892961 0.806 rs312910 chr17:75413961 A/C cg01320579 chr17:75405842 SEPT9 0.35 5.65 0.3 3.53e-8 Airflow obstruction; CRC cis rs4555082 0.874 rs2816626 chr14:105735425 G/A cg06808227 chr14:105710500 BRF1 -0.61 -8.68 -0.43 1.87e-16 Mean platelet volume;Platelet distribution width; CRC cis rs2457480 0.778 rs11238901 chr10:44681012 C/A cg09554077 chr10:44749378 NA 0.7 7.85 0.4 5.95e-14 Coronary artery disease; CRC cis rs644148 1.000 rs644148 chr19:44970935 T/G cg15540054 chr19:45004280 ZNF180 -0.68 -9.59 -0.47 2.37e-19 Personality dimensions; CRC cis rs7811142 1.000 rs11771241 chr7:99994785 G/A cg00814883 chr7:100076585 TSC22D4 -0.75 -9.34 -0.46 1.49e-18 Platelet count; CRC cis rs2228479 0.850 rs12596934 chr16:89841605 T/G cg06656553 chr16:89960601 TCF25 -0.71 -5.96 -0.31 6.42e-9 Skin colour saturation; CRC cis rs67311347 1.000 rs9829800 chr3:40443927 T/C cg09455208 chr3:40491958 NA 0.43 8.78 0.44 8.99e-17 Renal cell carcinoma; CRC cis rs66887589 0.560 rs9684327 chr4:120365441 A/G cg09307838 chr4:120376055 NA 0.54 8.4 0.42 1.32e-15 Diastolic blood pressure; CRC cis rs11792861 0.926 rs7470160 chr9:111844246 C/A cg05043794 chr9:111880884 C9orf5 -0.36 -6.59 -0.34 1.77e-10 Menarche (age at onset); CRC cis rs1577917 0.958 rs72907388 chr6:86440207 C/A cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.63 -7.99 -0.4 2.26e-14 Response to antipsychotic treatment; CRC cis rs55986470 0.817 rs6710301 chr2:239441308 A/C cg18131467 chr2:239335373 ASB1 0.55 5.77 0.3 1.8e-8 Chronotype; CRC cis rs6496667 1.000 rs3803539 chr15:90891982 A/G cg04176472 chr15:90893244 GABARAPL3 0.59 8.33 0.42 2.24e-15 Rheumatoid arthritis; CRC cis rs3772130 0.962 rs7629369 chr3:121566282 T/C cg20356878 chr3:121714668 ILDR1 0.52 8.21 0.41 5.11e-15 Cognitive performance; CRC cis rs2762353 0.595 rs12207270 chr6:25751721 A/G cg12310025 chr6:25882481 NA -0.72 -10.47 -0.5 2.51e-22 Blood metabolite levels; CRC cis rs12291225 0.585 rs11023194 chr11:14369769 T/C cg05501817 chr11:14380813 RRAS2 -0.47 -6.58 -0.34 1.87e-10 Sense of smell; CRC cis rs1023500 0.573 rs4822088 chr22:42470589 G/C cg15557168 chr22:42548783 NA -0.38 -6.43 -0.33 4.43e-10 Schizophrenia; CRC cis rs9467160 0.532 rs2744565 chr6:24458461 G/T cg20631270 chr6:24437470 GPLD1 -0.53 -7.94 -0.4 3.23e-14 Liver enzyme levels; CRC cis rs11997175 0.599 rs66474258 chr8:33640225 A/T ch.8.33884649F chr8:33765107 NA 0.48 7.74 0.39 1.27e-13 Body mass index; CRC cis rs72799341 0.706 rs889555 chr16:31122571 C/T cg02466173 chr16:30829666 NA -0.46 -6.22 -0.32 1.51e-9 Diastolic blood pressure; CRC cis rs11758351 0.660 rs11759904 chr6:26231443 T/C cg22723502 chr6:26240528 HIST1H4F -0.36 -5.92 -0.31 8.02e-9 Gout;Renal underexcretion gout; CRC cis rs13118159 0.550 rs28614045 chr4:1374695 C/A cg19318889 chr4:1322082 MAEA 0.65 9.63 0.47 1.7e-19 Longevity; CRC cis rs2281845 0.965 rs3738263 chr1:201083506 A/G cg24849736 chr1:201084428 NA 0.65 12.36 0.56 4.27e-29 Permanent tooth development; CRC cis rs11105298 0.891 rs10858889 chr12:89902604 G/A cg00757033 chr12:89920650 WDR51B 0.36 6.02 0.32 4.53e-9 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; CRC cis rs2576037 0.526 rs3892820 chr18:44479558 A/G cg19077165 chr18:44547161 KATNAL2 -0.58 -9.78 -0.47 5.38e-20 Personality dimensions; CRC cis rs2573652 0.755 rs6598286 chr15:100515985 G/T cg09918751 chr15:100517450 ADAMTS17 -0.39 -6.04 -0.32 4.22e-9 Height; CRC cis rs6964587 0.740 rs2020360 chr7:91439506 G/C cg17063962 chr7:91808500 NA 0.68 10.68 0.51 4.61e-23 Breast cancer; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg01657511 chr8:142318170 NA 0.41 6.81 0.35 4.57e-11 Liver disease severity in Alagille syndrome; CRC trans rs11098499 0.954 rs6848389 chr4:120402622 A/G cg25214090 chr10:38739885 LOC399744 0.65 10.26 0.49 1.35e-21 Corneal astigmatism; CRC cis rs35110281 0.693 rs2251253 chr21:45092257 T/A cg21573476 chr21:45109991 RRP1B -0.37 -5.78 -0.3 1.73e-8 Mean corpuscular volume; CRC cis rs7618915 0.508 rs12498066 chr3:52627660 G/A cg18404041 chr3:52824283 ITIH1 -0.43 -8.72 -0.43 1.39e-16 Bipolar disorder; CRC cis rs875971 0.862 rs12537823 chr7:65720884 C/T cg18876405 chr7:65276391 NA 0.5 8.13 0.41 8.69e-15 Aortic root size; CRC cis rs4625783 0.583 rs11077974 chr17:80095193 A/G cg13198984 chr17:80129470 CCDC57 0.46 8.16 0.41 6.94e-15 Blood metabolite levels; CRC cis rs6456156 0.774 rs6456158 chr6:167528032 A/C cg05540913 chr6:167530185 CCR6 0.4 7.35 0.38 1.53e-12 Primary biliary cholangitis; CRC cis rs10504229 0.683 rs11775568 chr8:58133762 G/A cg21724239 chr8:58056113 NA 0.74 9.41 0.46 8.98e-19 Developmental language disorder (linguistic errors); CRC cis rs644148 0.693 rs2686772 chr19:44999729 T/C cg15540054 chr19:45004280 ZNF180 -0.54 -6.88 -0.35 2.95e-11 Personality dimensions; CRC trans rs1005277 0.579 rs2505237 chr10:38438898 T/G cg27523141 chr10:43048294 ZNF37B 0.49 7.26 0.37 2.79e-12 Extrinsic epigenetic age acceleration; CRC cis rs10504229 1.000 rs67105789 chr8:58192002 G/T cg22535103 chr8:58192502 C8orf71 -0.82 -12.27 -0.56 9.63e-29 Developmental language disorder (linguistic errors); CRC cis rs17767392 0.846 rs34281405 chr14:71780587 G/A cg13720639 chr14:72061746 SIPA1L1 -0.45 -6.04 -0.32 4.17e-9 Mitral valve prolapse; CRC cis rs8014204 0.541 rs35591392 chr14:75157713 G/T cg03030879 chr14:75389066 RPS6KL1 -0.41 -6.38 -0.33 5.93e-10 Caffeine consumption; CRC cis rs1707322 0.752 rs11211147 chr1:46110094 A/G cg03146154 chr1:46216737 IPP 0.67 9.83 0.48 3.62e-20 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs7923609 0.967 rs10761751 chr10:65154885 A/G cg08743896 chr10:65200160 JMJD1C -0.41 -5.81 -0.31 1.45e-8 Educational attainment;Liver enzyme levels (alkaline phosphatase); CRC cis rs72627123 0.867 rs58102735 chr14:74467531 G/A cg12022184 chr14:74485813 ENTPD5;C14orf45 0.71 5.92 0.31 8.3e-9 Morning vs. evening chronotype; CRC cis rs2032447 0.798 rs807214 chr6:26061769 G/C cg27635394 chr6:26043820 HIST1H2BB 0.4 5.83 0.31 1.35e-8 Intelligence (multi-trait analysis); CRC cis rs11123170 0.543 rs2863242 chr2:113989236 C/T cg21550016 chr2:113992930 PAX8;LOC440839;LOC654433 0.52 6.01 0.31 5.05e-9 Renal function-related traits (BUN); CRC trans rs11098499 0.955 rs1511015 chr4:120170473 A/C cg25214090 chr10:38739885 LOC399744 0.51 7.88 0.4 4.77e-14 Corneal astigmatism; CRC cis rs2579500 0.807 rs4907200 chr2:97320737 T/G cg23100626 chr2:96804247 ASTL -0.23 -5.62 -0.3 3.97e-8 Eosinophil counts;Eosinophil percentage of white cells; CRC cis rs1538970 0.961 rs7553318 chr1:45843086 A/G cg05343316 chr1:45956843 TESK2 0.69 9.08 0.45 1.03e-17 Platelet count; CRC cis rs911119 0.913 rs3004139 chr20:23578674 C/T cg16589663 chr20:23618590 CST3 -0.44 -6.28 -0.33 1.1e-9 Chronic kidney disease; CRC cis rs6547741 0.743 rs7564625 chr2:27862397 C/T cg27432699 chr2:27873401 GPN1 -0.86 -16.9 -0.68 1.49e-46 Oral cavity cancer; CRC cis rs559928 0.606 rs11231726 chr11:63987339 C/T cg19465662 chr11:63993652 NUDT22;TRPT1 0.72 6.9 0.36 2.72e-11 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; CRC cis rs12451471 0.637 rs7567 chr17:78093549 G/T cg12100956 chr17:78086420 GAA -0.38 -5.83 -0.31 1.33e-8 Plateletcrit;Mean corpuscular hemoglobin concentration; CRC cis rs7927771 1.000 rs4752856 chr11:47648042 C/T cg05585544 chr11:47624801 NA -0.62 -11.43 -0.53 1.09e-25 Subjective well-being; CRC cis rs2297440 0.506 rs2236504 chr20:62224762 C/T cg06363034 chr20:62225388 GMEB2 -0.45 -6.88 -0.35 2.94e-11 Glioma;Non-glioblastoma glioma;Glioblastoma; CRC cis rs2404618 0.624 rs7012381 chr8:1475357 C/T cg13402656 chr8:1511478 DLGAP2 -0.48 -7.97 -0.4 2.65e-14 Lung cancer; CRC cis rs1580019 0.563 rs34201720 chr7:32568935 G/A cg14728415 chr7:32535168 LSM5;AVL9 0.43 6.18 0.32 1.89e-9 Cognitive ability; CRC cis rs728616 0.867 rs2152550 chr10:81818509 G/A cg05935833 chr10:81318306 SFTPA2 -0.51 -6.25 -0.33 1.24e-9 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs7927771 1.000 rs11039412 chr11:47841581 G/A cg18512352 chr11:47633146 NA -0.48 -9.37 -0.46 1.23e-18 Subjective well-being; CRC cis rs2949837 0.581 rs2965074 chr7:45983129 G/T cg10677697 chr7:45961126 IGFBP3 0.36 6.37 0.33 6.28e-10 Sitting height ratio; CRC cis rs7312933 0.558 rs11181466 chr12:42765181 A/T cg19980929 chr12:42632907 YAF2 0.42 6.29 0.33 1.04e-9 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CRC trans rs7647973 0.560 rs77473999 chr3:49777660 T/C cg21665057 chr3:196295764 WDR53;FBXO45 0.58 6.0 0.31 5.16e-9 Menarche (age at onset); CRC trans rs9291683 0.588 rs13133766 chr4:10019732 C/T cg26043149 chr18:55253948 FECH 0.51 7.91 0.4 3.95e-14 Bone mineral density; CRC cis rs10788264 0.504 rs7090214 chr10:124036494 T/C cg09507567 chr10:124027408 NA 0.36 7.65 0.39 2.2e-13 Total body bone mineral density; CRC cis rs6502050 0.799 rs7406257 chr17:80089340 G/A cg09264619 chr17:80180166 NA -0.36 -6.09 -0.32 3.09e-9 Life satisfaction; CRC cis rs62408225 1.000 rs17513531 chr6:90951239 C/T cg06866423 chr6:90926672 BACH2 0.46 7.45 0.38 8.19e-13 Eosinophil counts;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC cis rs9910055 0.530 rs2269907 chr17:42294215 G/A cg19774624 chr17:42201019 HDAC5 -0.39 -5.83 -0.31 1.32e-8 Total body bone mineral density; CRC cis rs2243480 1.000 rs34577383 chr7:65385726 C/T cg18252515 chr7:66147081 NA -1.08 -12.66 -0.57 3.44e-30 Diabetic kidney disease; CRC cis rs863345 0.604 rs4584390 chr1:158505975 T/A cg12129480 chr1:158549410 OR10X1 -0.3 -6.27 -0.33 1.12e-9 Pneumococcal bacteremia; CRC cis rs796364 0.901 rs35572201 chr2:201035093 T/C cg12253985 chr2:200820533 C2orf60;C2orf47 -0.53 -5.62 -0.3 4.03e-8 Schizophrenia; CRC cis rs10791323 0.536 rs1944731 chr11:133726067 G/A cg03690763 chr11:133734501 NA -0.39 -6.32 -0.33 8.29e-10 Childhood ear infection; CRC cis rs7259376 1.000 rs2163846 chr19:22505844 C/T cg02657401 chr19:22469223 NA -0.36 -8.17 -0.41 6.65e-15 Menopause (age at onset); CRC cis rs12580194 0.593 rs61957937 chr12:55746850 G/C cg23425280 chr12:56401806 NA 0.47 5.72 0.3 2.44e-8 Cancer; CRC cis rs780096 0.546 rs1104 chr2:27599875 T/G cg17158414 chr2:27665306 KRTCAP3 -0.28 -6.01 -0.31 5.01e-9 Total body bone mineral density; CRC cis rs4713118 0.699 rs573179 chr6:27849676 C/A cg02683197 chr6:28174875 NA 0.7 8.9 0.44 3.85e-17 Parkinson's disease; CRC cis rs10504229 0.639 rs72650811 chr8:58115661 G/A cg02290350 chr8:58132656 NA -0.58 -8.16 -0.41 7.29e-15 Developmental language disorder (linguistic errors); CRC cis rs12900413 0.687 rs28428808 chr15:90315516 C/T cg24249390 chr15:90295951 MESP1 -0.56 -8.9 -0.44 3.84e-17 Coronary artery aneurysm in Kawasaki disease; CRC trans rs561341 1.000 rs4795668 chr17:30244554 G/A cg27661571 chr11:113659931 NA -0.88 -10.42 -0.5 3.71e-22 Hip circumference adjusted for BMI; CRC cis rs10791323 0.593 rs10791329 chr11:133716356 T/C cg03690763 chr11:133734501 NA -0.36 -5.97 -0.31 6.24e-9 Childhood ear infection; CRC cis rs11997175 0.545 rs67960786 chr8:33668770 G/A ch.8.33884649F chr8:33765107 NA 0.39 5.76 0.3 1.9e-8 Body mass index; CRC cis rs6662572 0.737 rs6687316 chr1:46581449 G/A cg03123370 chr1:45965343 CCDC163P;MMACHC 0.47 6.3 0.33 9.58e-10 Blood protein levels; CRC cis rs9372498 0.536 rs62422236 chr6:118972633 G/T cg22561889 chr6:118971681 C6orf204 0.48 5.8 0.3 1.6e-8 Diastolic blood pressure; CRC cis rs870825 0.616 rs56844261 chr4:185632478 T/C cg04058563 chr4:185651563 MLF1IP 0.73 9.38 0.46 1.13e-18 Blood protein levels; CRC cis rs17767392 0.881 rs1029570 chr14:72043200 A/G cg13720639 chr14:72061746 SIPA1L1 0.57 7.02 0.36 1.25e-11 Mitral valve prolapse; CRC trans rs711355 0.902 rs1085232 chr15:30189454 G/A cg19414016 chr13:113697165 MCF2L -0.42 -6.24 -0.33 1.37e-9 Response to antipsychotic treatment; CRC cis rs7829975 0.508 rs4841006 chr8:8501474 T/C cg08975724 chr8:8085496 FLJ10661 -0.38 -5.85 -0.31 1.21e-8 Mood instability; CRC cis rs6988985 0.728 rs10105643 chr8:143957886 A/C cg10324643 chr8:143916377 GML 0.4 6.6 0.34 1.68e-10 Plasma androstenedione levels in resected early stage-receptor positive breast cancer; CRC cis rs3768617 0.528 rs2027082 chr1:183084608 C/A ch.1.3577855R chr1:183094577 LAMC1 0.89 15.85 0.66 1.97e-42 Fuchs's corneal dystrophy; CRC cis rs34172651 0.517 rs11642954 chr16:24824248 G/A cg06505273 chr16:24850292 NA 0.51 6.61 0.34 1.57e-10 Intelligence (multi-trait analysis); CRC cis rs8072100 0.846 rs6503796 chr17:45765249 T/C cg08085267 chr17:45401833 C17orf57 -0.57 -8.8 -0.44 7.95e-17 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs10982256 0.567 rs10817620 chr9:117238405 C/T cg13636371 chr9:117264095 DFNB31 0.33 6.32 0.33 8.35e-10 Bipolar disorder; CRC cis rs10504073 0.584 rs55908480 chr8:49923431 G/A cg00325661 chr8:49890786 NA 0.62 11.23 0.53 5.31e-25 Blood metabolite ratios; CRC trans rs1814175 0.817 rs1319547 chr11:49916705 C/T cg11707556 chr5:10655725 ANKRD33B -0.42 -7.98 -0.4 2.5e-14 Height; CRC cis rs6860806 0.507 rs183898 chr5:131716902 C/G cg04518342 chr5:131593106 PDLIM4 -0.44 -7.13 -0.37 6.23e-12 Breast cancer; CRC cis rs2898681 0.580 rs41279517 chr4:53729771 T/C cg26260408 chr4:53727979 RASL11B 0.5 5.73 0.3 2.29e-8 Optic nerve measurement (cup area); CRC trans rs916888 0.773 rs199447 chr17:44812188 C/T cg13957321 chr17:43675089 NA 0.5 6.23 0.32 1.45e-9 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs2204008 0.658 rs12371956 chr12:38298010 A/T cg13010199 chr12:38710504 ALG10B 0.46 6.25 0.33 1.3e-9 Bladder cancer; CRC cis rs71227278 1 rs71227278 chr12:54358047 C/CTTAA cg19188855 chr12:54355476 NA 0.33 6.82 0.35 4.49e-11 Urinary tract infection frequency; CRC cis rs4665809 0.590 rs2289019 chr2:26420809 G/C cg25036284 chr2:26402008 FAM59B -0.6 -7.65 -0.39 2.29e-13 Gut microbiome composition (summer); CRC trans rs6544773 0.668 rs543541 chr2:45071204 G/A cg10208897 chr5:178548229 ADAMTS2 0.35 6.03 0.32 4.53e-9 Mosquito bite size; CRC cis rs4780401 0.782 rs933573 chr16:11793395 A/G cg01061890 chr16:11836724 TXNDC11 0.43 6.25 0.33 1.29e-9 Rheumatoid arthritis; CRC cis rs7618915 0.571 rs6798246 chr3:52599922 G/A cg11645453 chr3:52864694 ITIH4 0.35 6.11 0.32 2.81e-9 Bipolar disorder; CRC cis rs7827545 0.620 rs6578009 chr8:135522989 T/C cg09855544 chr8:135498122 ZFAT -0.43 -5.75 -0.3 2.09e-8 Hypertension (SNP x SNP interaction); CRC cis rs1801251 0.752 rs709938 chr2:233746457 C/T cg25237894 chr2:233734115 C2orf82 -0.63 -11.14 -0.52 1.15e-24 Coronary artery disease; CRC cis rs2153535 0.580 rs9378551 chr6:8463744 A/G cg21535247 chr6:8435926 SLC35B3 0.5 7.53 0.38 4.89e-13 Motion sickness; CRC cis rs3820068 0.581 rs72645895 chr1:15931709 G/A cg13390004 chr1:15929781 NA 0.51 7.2 0.37 4.22e-12 Systolic blood pressure; CRC cis rs10832963 0.686 rs11024743 chr11:18653712 A/G cg09201001 chr11:18656081 SPTY2D1 0.8 12.35 0.56 4.76e-29 Breast cancer; CRC cis rs17376456 0.825 rs13155452 chr5:93164449 C/T cg21475434 chr5:93447410 FAM172A -0.63 -6.36 -0.33 6.6e-10 Diabetic retinopathy; CRC cis rs6502050 0.799 rs12940433 chr17:80120826 C/T cg19223190 chr17:80058835 NA 0.39 6.23 0.32 1.43e-9 Life satisfaction; CRC cis rs11155671 0.530 rs9969044 chr6:150209204 A/G cg13206674 chr6:150067644 NUP43 0.51 6.81 0.35 4.79e-11 Testicular germ cell tumor; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg13826618 chr2:11828697 NA 0.42 6.22 0.32 1.47e-9 Intelligence (multi-trait analysis); CRC cis rs6502050 0.799 rs8069827 chr17:80089168 C/T cg13198984 chr17:80129470 CCDC57 0.47 8.45 0.42 9.24e-16 Life satisfaction; CRC cis rs6502050 0.835 rs67106357 chr17:80116826 T/G cg09264619 chr17:80180166 NA -0.35 -5.97 -0.31 5.98e-9 Life satisfaction; CRC trans rs10983614 1.000 rs7867776 chr9:120072627 A/G cg18864399 chr15:73345368 NEO1 0.47 6.31 0.33 9e-10 Survival in pancreatic cancer; CRC cis rs4563143 0.675 rs112383987 chr19:29261081 C/T cg12756686 chr19:29218302 NA 0.6 8.99 0.44 2.04e-17 Methadone dose in opioid dependence; CRC trans rs8002861 0.691 rs9525851 chr13:44402132 T/A cg12856521 chr11:46389249 DGKZ -0.5 -8.2 -0.41 5.3e-15 Leprosy; CRC cis rs4819052 0.851 rs4819041 chr21:46659955 C/T cg11663144 chr21:46675770 NA -0.68 -11.28 -0.53 3.5e-25 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs2032447 0.802 rs12346 chr6:26097046 T/C cg26028573 chr6:26043587 HIST1H2BB 0.46 6.63 0.34 1.38e-10 Intelligence (multi-trait analysis); CRC cis rs2032447 0.530 rs9356996 chr6:26008487 C/A cg04800585 chr6:26043546 HIST1H2BB 0.41 6.18 0.32 1.86e-9 Intelligence (multi-trait analysis); CRC trans rs8073060 0.660 rs58266733 chr17:34003812 A/T cg19694781 chr19:47549865 TMEM160 -1.07 -14.34 -0.62 1.5e-36 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; CRC cis rs1564271 0.553 rs2489583 chr10:26987698 A/G cg24343755 chr10:26987087 PDSS1 -0.53 -7.07 -0.36 9.24e-12 Overall survival in serous epithelial ovarian cancer treated with paclitaxel and cisplatin; CRC cis rs1008375 1.000 rs28545485 chr4:17645376 C/T cg16339924 chr4:17578868 LAP3 0.58 7.9 0.4 4.3e-14 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs12477438 0.765 rs12468807 chr2:99691994 C/A cg26064155 chr2:99771622 LIPT1;TSGA10 -0.79 -11.23 -0.53 5.57e-25 Chronic sinus infection; CRC cis rs6543140 0.964 rs6761350 chr2:103030776 A/G cg09003973 chr2:102972529 NA 0.41 5.68 0.3 2.96e-8 Blood protein levels; CRC trans rs72991 0.595 rs10892742 chr11:121229932 G/A cg27192990 chr6:129479024 LAMA2 -0.44 -6.32 -0.33 8.49e-10 Response to tocilizumab in rheumatoid arthritis; CRC cis rs2050392 0.624 rs303444 chr10:30729347 C/T cg18806716 chr10:30721971 MAP3K8 -0.7 -10.18 -0.49 2.49e-21 Inflammatory bowel disease; CRC cis rs6586163 0.872 rs7910825 chr10:90743341 G/A cg03111039 chr10:90751583 FAS;ACTA2 -0.5 -7.08 -0.36 8.67e-12 Chronic lymphocytic leukemia; CRC cis rs2062225 1.000 rs1483535 chr2:111759661 G/T cg11729679 chr2:111877065 BCL2L11 -0.56 -5.64 -0.3 3.67e-8 Monocyte count; CRC cis rs9648716 1.000 rs6964724 chr7:140501936 G/A cg10747023 chr7:140774559 NA 0.46 5.98 0.31 5.69e-9 Type 2 diabetes; CRC cis rs3126085 0.935 rs1858480 chr1:152301735 A/G cg09127314 chr1:152161683 NA -0.49 -6.34 -0.33 7.41e-10 Atopic dermatitis; CRC cis rs2658782 0.724 rs2605629 chr11:93264037 C/G cg15737290 chr11:93063684 CCDC67 -0.53 -7.67 -0.39 1.96e-13 Pulmonary function decline; CRC cis rs4728302 0.869 rs13233690 chr7:133587328 C/T cg03336402 chr7:133662267 EXOC4 -0.44 -6.37 -0.33 6.27e-10 Intelligence;Intelligence (multi-trait analysis); CRC cis rs854572 0.870 rs757158 chr7:94955528 C/T cg05342682 chr7:94953680 PON1 -0.53 -8.21 -0.41 4.93e-15 Paraoxonase activity; CRC trans rs7395662 0.804 rs8186428 chr11:48734677 C/T cg21153622 chr11:89784906 NA -0.48 -7.67 -0.39 2.02e-13 HDL cholesterol; CRC cis rs1552244 0.882 rs7636817 chr3:10014876 G/T cg08888203 chr3:10149979 C3orf24 0.62 8.26 0.41 3.67e-15 Alzheimer's disease; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg11786013 chr1:36622167 MAP7D1 0.41 6.32 0.33 8.35e-10 Intelligence (multi-trait analysis); CRC cis rs35110281 0.633 rs2329593 chr21:45121987 T/C cg21573476 chr21:45109991 RRP1B -0.39 -5.8 -0.3 1.55e-8 Mean corpuscular volume; CRC cis rs7215564 0.908 rs9908112 chr17:78753455 A/G cg09596252 chr17:78655493 RPTOR -0.64 -5.79 -0.3 1.68e-8 Myopia (pathological); CRC cis rs3741798 0.908 rs61922046 chr12:12495675 A/T cg08615371 chr12:12503544 MANSC1 1.02 8.98 0.44 2.1e-17 Cerebrospinal fluid biomarker levels; CRC cis rs12024301 0.557 rs11803516 chr1:183640687 T/A cg11505048 chr1:183622726 RGL1;APOBEC4 0.81 7.06 0.36 1.01e-11 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs826838 1.000 rs10875991 chr12:39108886 G/C cg26384229 chr12:38710491 ALG10B 0.73 10.2 0.49 2.1e-21 Heart rate; CRC cis rs1862618 0.853 rs860580 chr5:56149429 G/T cg22800045 chr5:56110881 MAP3K1 -0.54 -6.05 -0.32 3.96e-9 Initial pursuit acceleration; CRC cis rs2479724 0.935 rs7753507 chr6:41784094 C/T cg17623882 chr6:41773611 USP49 0.57 9.91 0.48 1.97e-20 Menarche (age at onset); CRC cis rs5769765 0.908 rs9616376 chr22:50310829 A/G cg02269571 chr22:50332266 NA -0.6 -7.79 -0.39 8.72e-14 Schizophrenia; CRC cis rs6604026 0.656 rs2481713 chr1:93354889 G/T cg17283838 chr1:93427260 FAM69A -0.45 -5.87 -0.31 1.07e-8 Multiple sclerosis; CRC cis rs597539 0.616 rs473997 chr11:68639481 C/T cg04772025 chr11:68637568 NA 0.5 7.41 0.38 1.05e-12 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs10504229 1.000 rs60231757 chr8:58169937 T/C cg24829409 chr8:58192753 C8orf71 -0.68 -11.34 -0.53 2.27e-25 Developmental language disorder (linguistic errors); CRC cis rs9914988 0.887 rs11656272 chr17:27091153 A/G cg07195577 chr17:27052828 TLCD1 0.42 6.03 0.32 4.32e-9 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC trans rs9393777 0.622 rs13191326 chr6:27031029 A/G cg06606381 chr12:133084897 FBRSL1 -0.93 -7.09 -0.36 8.01e-12 Intelligence (multi-trait analysis); CRC cis rs4728302 0.869 rs10954434 chr7:133597864 A/G cg10665199 chr7:133106180 EXOC4 0.38 5.77 0.3 1.8e-8 Intelligence;Intelligence (multi-trait analysis); CRC cis rs4862750 0.832 rs6419953 chr4:187900509 T/A cg06074448 chr4:187884817 NA -0.6 -11.3 -0.53 2.95e-25 Lobe attachment (rater-scored or self-reported); CRC trans rs7615952 0.515 rs7637246 chr3:125678706 A/G cg07211511 chr3:129823064 LOC729375 -0.69 -8.85 -0.44 5.66e-17 Blood pressure (smoking interaction); CRC cis rs208520 0.955 rs12202599 chr6:67001573 A/G cg07460842 chr6:66804631 NA 0.84 10.26 0.49 1.32e-21 Exhaled nitric oxide output; CRC cis rs711245 0.670 rs7560321 chr2:36822318 C/G cg09467607 chr2:36825704 FEZ2 -0.67 -12.36 -0.56 4.39e-29 Height; CRC cis rs9902453 0.904 rs4077465 chr17:28300144 T/C cg26525008 chr17:28256777 EFCAB5;SSH2 0.69 11.24 0.53 5.04e-25 Coffee consumption (cups per day); CRC cis rs4780401 0.609 rs4781142 chr16:11808806 T/C cg01061890 chr16:11836724 TXNDC11 -0.62 -9.12 -0.45 7.41e-18 Rheumatoid arthritis; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg19602773 chr3:52007747 ABHD14B;ABHD14A -0.43 -6.73 -0.35 7.64e-11 Myopia (pathological); CRC cis rs8180040 0.726 rs13094672 chr3:47149439 C/T cg10298567 chr3:47292165 KIF9 -0.37 -5.88 -0.31 1.03e-8 Colorectal cancer; CRC cis rs394563 0.591 rs237029 chr6:149717425 A/G cg03678062 chr6:149772716 ZC3H12D -0.35 -6.44 -0.33 4.3e-10 Dupuytren's disease; CRC cis rs7607369 0.618 rs62193298 chr2:219655211 T/G cg02176678 chr2:219576539 TTLL4 -0.56 -8.93 -0.44 2.99e-17 Red blood cell count;Amyotrophic lateral sclerosis; CRC cis rs28386778 1.000 rs2665849 chr17:61953670 T/C cg25654072 chr17:61904446 PSMC5;FTSJ3 0.71 11.07 0.52 2e-24 Prudent dietary pattern; CRC cis rs2836974 0.602 rs8130854 chr21:40707041 G/A cg11890956 chr21:40555474 PSMG1 -0.83 -13.32 -0.59 1.12e-32 Cognitive function; CRC cis rs12580194 0.593 rs7971053 chr12:55729947 A/C cg19537932 chr12:55886519 OR6C68 -0.66 -8.59 -0.43 3.63e-16 Cancer; CRC cis rs17826219 0.706 rs609472 chr17:28951427 T/C cg13385521 chr17:29058706 SUZ12P 0.47 5.88 0.31 1.02e-8 Body mass index; CRC trans rs17665859 0.669 rs56187424 chr8:447194 A/G cg18996590 chr8:30890583 WRN;PURG -0.45 -6.26 -0.33 1.19e-9 Bilirubin levels; CRC cis rs2304069 0.545 rs13168011 chr5:149392377 C/T cg12661370 chr5:149340060 SLC26A2 0.43 6.19 0.32 1.76e-9 HIV-1 control; CRC cis rs4555082 0.874 rs2816613 chr14:105726367 C/T cg10792982 chr14:105748885 BRF1 0.37 6.03 0.32 4.33e-9 Mean platelet volume;Platelet distribution width; CRC cis rs2404602 0.716 rs7179142 chr15:76698268 G/A cg23625390 chr15:77176239 SCAPER 0.48 7.05 0.36 1.04e-11 Blood metabolite levels; CRC trans rs7267979 1.000 rs6050602 chr20:25401203 A/G cg17903999 chr18:56338584 MALT1 0.41 6.92 0.36 2.4e-11 Liver enzyme levels (alkaline phosphatase); CRC cis rs11252926 0.550 rs11252134 chr10:442599 G/A cg16386425 chr10:429943 DIP2C -0.44 -6.67 -0.35 1.07e-10 Psychosis in Alzheimer's disease; CRC cis rs9372498 0.536 rs62422227 chr6:118957200 C/G cg24463073 chr6:118973353 C6orf204 0.48 6.21 0.32 1.61e-9 Diastolic blood pressure; CRC cis rs6504622 0.577 rs197925 chr17:45010721 C/T cg16759221 chr17:45003025 GOSR2 -0.62 -10.09 -0.49 4.82e-21 Orofacial clefts; CRC cis rs7945718 0.905 rs4454698 chr11:12720560 A/G cg25843174 chr11:12811716 TEAD1 -0.47 -8.93 -0.44 2.98e-17 Educational attainment (years of education); CRC cis rs4588572 0.615 rs4143070 chr5:77769094 G/C cg11446398 chr5:77624930 NA 0.43 6.32 0.33 8.52e-10 Triglycerides; CRC cis rs7809950 1.000 rs4727680 chr7:107087407 T/G cg23024343 chr7:107201750 COG5 -0.61 -8.75 -0.43 1.11e-16 Coronary artery disease; CRC cis rs7666738 0.830 rs35915560 chr4:98978649 C/T cg05340658 chr4:99064831 C4orf37 0.6 9.36 0.46 1.26e-18 Colonoscopy-negative controls vs population controls; CRC cis rs10504229 0.683 rs56196593 chr8:58141898 G/A cg05313129 chr8:58192883 C8orf71 -0.44 -6.12 -0.32 2.72e-9 Developmental language disorder (linguistic errors); CRC cis rs11971779 0.523 rs10279160 chr7:139090761 A/G cg07862535 chr7:139043722 LUC7L2 0.57 7.35 0.38 1.61e-12 Diisocyanate-induced asthma; CRC cis rs7274811 0.723 rs6120329 chr20:32210238 T/G cg07470512 chr20:32255052 NECAB3;C20orf134 -0.44 -5.75 -0.3 2e-8 Height; CRC trans rs7937682 0.921 rs12806479 chr11:111443192 G/C cg18187862 chr3:45730750 SACM1L -0.53 -6.97 -0.36 1.74e-11 Primary sclerosing cholangitis; CRC cis rs4665809 1.000 rs4665809 chr2:26251361 C/T cg26119090 chr2:26468346 HADHA;HADHB 0.61 7.72 0.39 1.4e-13 Gut microbiome composition (summer); CRC cis rs2734839 0.964 rs12808482 chr11:113294998 T/A cg14159747 chr11:113255604 NA 0.46 7.95 0.4 2.96e-14 Information processing speed; CRC cis rs898097 0.812 rs55794221 chr17:80849003 G/A cg16060761 chr17:80687452 NA 0.42 6.07 0.32 3.46e-9 Breast cancer; CRC cis rs1109861 0.593 rs658681 chr10:11218580 A/G cg24910943 chr10:11206320 CUGBP2 0.27 7.59 0.39 3.34e-13 Urinary albumin-to-creatinine ratio; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg20609493 chr15:60420227 NA 0.49 6.48 0.34 3.38e-10 Thyroid stimulating hormone; CRC cis rs4713118 0.539 rs200951 chr6:27835930 A/G cg21204522 chr6:27730016 NA -0.4 -5.64 -0.3 3.64e-8 Parkinson's disease; CRC cis rs6534441 0.727 rs74953168 chr4:125466534 A/G cg21609808 chr4:125404261 NA 0.41 5.64 0.3 3.68e-8 Major depressive disorder; CRC cis rs7258465 0.965 rs2385088 chr19:18545540 A/G cg10790698 chr19:18539756 SSBP4 -0.47 -8.61 -0.43 3.06e-16 Breast cancer; CRC cis rs6586163 1.000 rs1324551 chr10:90751516 C/T cg03111039 chr10:90751583 FAS;ACTA2 -0.51 -7.41 -0.38 1.05e-12 Chronic lymphocytic leukemia; CRC cis rs13266463 0.830 rs7014552 chr8:143410423 A/G cg24996280 chr8:143481281 TSNARE1 0.36 5.97 0.31 6e-9 Schizophrenia; CRC cis rs1506636 0.720 rs633590 chr7:123442156 G/A cg03229431 chr7:123269106 ASB15 0.51 8.16 0.41 7.15e-15 Plateletcrit;Platelet count; CRC cis rs9660180 0.967 rs10907191 chr1:1774820 A/T cg03396347 chr1:1875803 NA -0.62 -9.41 -0.46 8.62e-19 Body mass index; CRC cis rs7772486 0.790 rs9497431 chr6:146248177 T/C cg13319975 chr6:146136371 FBXO30 0.43 6.54 0.34 2.4e-10 Lobe attachment (rater-scored or self-reported); CRC trans rs7647973 0.626 rs2131108 chr3:49665390 C/T cg21665057 chr3:196295764 WDR53;FBXO45 -0.67 -7.42 -0.38 1e-12 Menarche (age at onset); CRC cis rs16975963 0.793 rs73041034 chr19:38286272 G/A cg15135657 chr19:38346511 NA -0.44 -5.89 -0.31 9.55e-9 Longevity; CRC cis rs35110281 0.811 rs4819264 chr21:45017349 G/T cg04455712 chr21:45112962 RRP1B 0.41 8.08 0.41 1.22e-14 Mean corpuscular volume; CRC cis rs2836974 0.644 rs11088471 chr21:40699313 A/G cg11644478 chr21:40555479 PSMG1 -0.61 -9.32 -0.46 1.73e-18 Cognitive function; CRC cis rs6604026 0.883 rs7514280 chr1:93320869 C/T cg22128645 chr1:93425802 FAM69A -0.39 -5.81 -0.31 1.47e-8 Multiple sclerosis; CRC cis rs7617773 0.780 rs7645425 chr3:48362369 A/T cg11946769 chr3:48343235 NME6 0.72 9.58 0.47 2.48e-19 Coronary artery disease; CRC cis rs6499255 0.951 rs7186002 chr16:69751065 C/G cg04110750 chr16:69646130 NFAT5 -0.54 -7.34 -0.38 1.66e-12 IgE levels; CRC cis rs1223397 0.938 rs17767967 chr6:13282067 C/T cg07912922 chr6:13274314 PHACTR1 0.53 6.44 0.33 4.2e-10 Blood pressure; CRC cis rs12451471 0.667 rs12942002 chr17:78101629 C/G cg20811857 chr17:78079795 GAA -0.45 -6.4 -0.33 5.45e-10 Plateletcrit;Mean corpuscular hemoglobin concentration; CRC cis rs13118159 0.742 rs7679860 chr4:1333987 C/T cg16405210 chr4:1374714 KIAA1530 -0.57 -8.04 -0.41 1.65e-14 Longevity; CRC cis rs7772486 0.790 rs2247206 chr6:146216184 C/T cg23711669 chr6:146136114 FBXO30 0.66 11.25 0.53 4.47e-25 Lobe attachment (rater-scored or self-reported); CRC cis rs736408 0.812 rs6778329 chr3:52824610 G/A cg11645453 chr3:52864694 ITIH4 0.4 6.72 0.35 8.18e-11 Bipolar disorder; CRC cis rs17345786 0.861 rs17402964 chr3:101067945 C/T cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.56 6.58 0.34 1.85e-10 Colonoscopy-negative controls vs population controls; CRC trans rs12310956 0.532 rs7967627 chr12:33974669 G/T cg26384229 chr12:38710491 ALG10B 0.47 6.37 0.33 6.53e-10 Morning vs. evening chronotype; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg11531628 chr1:27930643 AHDC1 0.39 6.17 0.32 2.02e-9 Liver disease severity in Alagille syndrome; CRC cis rs8062405 0.754 rs3859172 chr16:28566158 G/T cg05139728 chr16:28306816 SBK1 -0.34 -5.82 -0.31 1.4e-8 Cognitive ability (multi-trait analysis);Cognitive ability; CRC cis rs9549328 0.670 rs2873372 chr13:113613383 A/G cg08614441 chr13:113633676 MCF2L -0.4 -7.0 -0.36 1.42e-11 Systolic blood pressure; CRC cis rs6964587 1.000 rs3753108 chr7:91629984 T/G cg17063962 chr7:91808500 NA 0.83 14.9 0.63 1.04e-38 Breast cancer; CRC cis rs9467711 0.675 rs58825580 chr6:26365679 T/G cg14345882 chr6:26364793 BTN3A2 0.64 6.12 0.32 2.66e-9 Autism spectrum disorder or schizophrenia; CRC cis rs11190604 1.000 rs10786597 chr10:102291287 C/T cg07080220 chr10:102295463 HIF1AN 0.47 5.65 0.3 3.39e-8 Palmitoleic acid (16:1n-7) levels; CRC cis rs7072216 0.770 rs7897357 chr10:100163597 C/T cg26618903 chr10:100175079 PYROXD2 -0.41 -6.89 -0.36 2.8e-11 Metabolite levels; CRC cis rs2396545 0.591 rs12802200 chr11:566936 C/A cg03352830 chr11:487213 PTDSS2 0.44 5.63 0.3 3.77e-8 Systemic lupus erythematosus and Systemic sclerosis; CRC cis rs2455601 0.671 rs10840135 chr11:8879794 T/C cg21881798 chr11:8931708 C11orf17;ST5 -0.54 -7.02 -0.36 1.25e-11 Schizophrenia; CRC cis rs875971 0.964 rs6978429 chr7:65959876 T/G cg00343986 chr7:65444356 GUSB 0.44 6.47 0.34 3.56e-10 Aortic root size; CRC cis rs7665939 1.000 rs72727639 chr4:190107992 G/C cg09826759 chr4:190284978 NA -0.74 -6.21 -0.32 1.61e-9 Amyotrophic lateral sclerosis; CRC cis rs4713118 0.869 rs9295743 chr6:27715102 G/C cg15786705 chr6:28176104 NA 0.55 7.73 0.39 1.34e-13 Parkinson's disease; CRC cis rs916888 0.821 rs199504 chr17:44861003 C/T cg17911788 chr17:44343683 NA 0.55 6.63 0.34 1.41e-10 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs10504229 0.679 rs11783965 chr8:58130510 T/G cg02290350 chr8:58132656 NA -0.57 -8.09 -0.41 1.2e-14 Developmental language disorder (linguistic errors); CRC cis rs7412746 0.611 rs16827671 chr1:150738759 T/C cg17724175 chr1:150552817 MCL1 0.47 6.95 0.36 1.93e-11 Melanoma; CRC cis rs929354 0.772 rs10229630 chr7:157004790 C/T cg05182265 chr7:156933206 UBE3C -0.76 -14.26 -0.62 2.92e-36 Body mass index; CRC cis rs763014 0.966 rs4984903 chr16:680695 A/G cg02475695 chr16:616220 NHLRC4 0.44 7.22 0.37 3.6e-12 Height; CRC cis rs7772486 0.754 rs697053 chr6:145989807 T/C cg23711669 chr6:146136114 FBXO30 -0.75 -12.68 -0.57 2.77e-30 Lobe attachment (rater-scored or self-reported); CRC cis rs7776786 0.870 rs12540224 chr7:18830489 C/T cg13420273 chr7:18810212 HDAC9 -0.31 -6.15 -0.32 2.2e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs7647973 0.925 rs9834003 chr3:49216472 T/C cg07690219 chr3:49449608 TCTA;RHOA -0.51 -6.04 -0.32 4.2e-9 Menarche (age at onset); CRC cis rs7726839 0.526 rs11960158 chr5:568665 C/T cg09021430 chr5:549028 NA -0.84 -11.01 -0.52 3.21e-24 Obesity-related traits; CRC cis rs6502050 0.835 rs8081949 chr17:80117490 G/A cg13198984 chr17:80129470 CCDC57 0.46 8.18 0.41 6.3e-15 Life satisfaction; CRC cis rs12802200 0.535 rs35391985 chr11:570280 T/C cg09218773 chr11:619014 MUPCDH -0.36 -5.68 -0.3 2.94e-8 Systemic lupus erythematosus; CRC cis rs9443189 0.762 rs2748943 chr6:76435543 C/T cg01950844 chr6:76311363 SENP6 -0.69 -9.38 -0.46 1.14e-18 Prostate cancer; CRC cis rs6951245 1.000 rs78628466 chr7:1068453 G/C cg21664854 chr7:1097933 C7orf50;GPR146 0.79 8.92 0.44 3.39e-17 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs4478858 0.746 rs7520468 chr1:31688812 G/A cg00250761 chr1:31883323 NA 0.31 5.82 0.31 1.4e-8 Alcohol dependence; CRC cis rs9715521 0.935 rs6818912 chr4:59834738 A/G cg11281224 chr4:60001000 NA -0.38 -5.73 -0.3 2.22e-8 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs7659604 0.967 rs10008348 chr4:122666987 A/C cg19748678 chr4:122722346 EXOSC9 0.55 8.72 0.43 1.41e-16 Type 2 diabetes; CRC cis rs11122272 0.735 rs2808602 chr1:231537303 A/G cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.57 -8.6 -0.43 3.21e-16 Hemoglobin concentration; CRC cis rs7762018 0.891 rs1981069 chr6:170148837 G/A cg19338460 chr6:170058176 WDR27 -0.69 -7.6 -0.39 3.03e-13 Thiazide-induced adverse metabolic effects in hypertensive patients; CRC cis rs7264396 0.676 rs6060727 chr20:34556000 G/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.61 -9.9 -0.48 2.17e-20 Total cholesterol levels; CRC cis rs912057 0.671 rs1294420 chr6:6742752 C/T cg06612196 chr6:6737390 NA 0.55 8.86 0.44 5.28e-17 Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction); CRC cis rs62103177 0.733 rs62103193 chr18:77629217 C/T cg12964065 chr18:77638022 KCNG2 0.66 6.69 0.35 9.56e-11 Opioid sensitivity; CRC cis rs1577917 0.958 rs13201730 chr6:86556647 T/A cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.54 -6.7 -0.35 8.8e-11 Response to antipsychotic treatment; CRC cis rs9303542 0.559 rs12602539 chr17:46617459 T/A cg04904318 chr17:46607828 HOXB1 -0.52 -6.11 -0.32 2.82e-9 Ovarian cancer;Epithelial ovarian cancer; CRC cis rs12620999 0.774 rs2875726 chr2:237954576 T/C cg23555395 chr2:238036564 NA 0.49 7.79 0.39 8.85e-14 Systemic lupus erythematosus; CRC cis rs2415984 0.579 rs2100337 chr14:46966088 T/C cg14871534 chr14:47121158 RPL10L -0.4 -6.01 -0.31 5.05e-9 Number of children ever born; CRC cis rs2268667 0.511 rs1874807 chr1:85779393 A/G cg27183818 chr1:85764021 NA 0.43 6.69 0.35 9.81e-11 Asymmetrical dimethylarginine levels; CRC cis rs4555082 0.834 rs2735825 chr14:105710900 G/A cg06808227 chr14:105710500 BRF1 -0.61 -8.66 -0.43 2.18e-16 Mean platelet volume;Platelet distribution width; CRC cis rs9858542 0.953 rs6446264 chr3:49417243 C/A cg03060546 chr3:49711283 APEH -0.48 -6.81 -0.35 4.64e-11 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs7811142 1.000 rs11761784 chr7:100039970 C/T cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.75 10.81 0.51 1.64e-23 Platelet count; CRC trans rs1814175 0.791 rs10839468 chr11:49986288 A/G cg11707556 chr5:10655725 ANKRD33B -0.42 -8.01 -0.4 2.02e-14 Height; CRC cis rs9937943 0.614 rs35148538 chr16:74613575 G/C cg01733217 chr16:74700730 RFWD3 0.72 7.56 0.38 4e-13 Neutrophil percentage of white cells; CRC cis rs875971 0.965 rs7794930 chr7:65778546 A/C cg18912574 chr7:65842487 NCRNA00174 -0.36 -6.06 -0.32 3.76e-9 Aortic root size; CRC cis rs8180040 0.966 rs9683033 chr3:47489820 C/T cg10298567 chr3:47292165 KIF9 -0.36 -5.86 -0.31 1.13e-8 Colorectal cancer; CRC cis rs6496667 0.865 rs10438436 chr15:90908781 A/G cg04176472 chr15:90893244 GABARAPL3 -0.59 -8.14 -0.41 7.97e-15 Rheumatoid arthritis; CRC cis rs2075371 0.932 rs34664116 chr7:133984878 G/A cg20476274 chr7:133979776 SLC35B4 0.74 12.62 0.57 4.66e-30 Mean platelet volume; CRC trans rs9329221 0.905 rs17765901 chr8:10249480 G/T cg06636001 chr8:8085503 FLJ10661 -0.56 -8.98 -0.44 2.2e-17 Neuroticism; CRC cis rs12477438 0.765 rs1115756 chr2:99659845 C/A cg26064155 chr2:99771622 LIPT1;TSGA10 -0.63 -8.55 -0.43 4.61e-16 Chronic sinus infection; CRC cis rs939584 1.000 rs4854347 chr2:641159 A/C cg03610516 chr2:642275 NA 0.42 5.88 0.31 9.94e-9 Body mass index; CRC cis rs798554 0.591 rs1182156 chr7:2901084 G/T cg19717773 chr7:2847554 GNA12 -0.35 -5.62 -0.3 4.15e-8 Height; CRC cis rs875971 0.867 rs1002053 chr7:65798545 G/A cg12463550 chr7:65579703 CRCP -0.49 -7.07 -0.36 9.23e-12 Aortic root size; CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg03069383 chr2:18741691 RDH14 0.39 6.01 0.31 4.91e-9 Obesity-related traits; CRC cis rs11212617 1.000 rs11212615 chr11:108281267 G/A cg12106634 chr11:108092400 ATM;NPAT 0.43 6.25 0.33 1.26e-9 Response to metformin in type 2 diabetes (glycemic); CRC cis rs10504229 1.000 rs73609764 chr8:58192971 G/A cg05313129 chr8:58192883 C8orf71 -0.47 -6.99 -0.36 1.49e-11 Developmental language disorder (linguistic errors); CRC cis rs1552244 0.554 rs13079240 chr3:10047246 C/T cg16606324 chr3:10149918 C3orf24 0.48 7.03 0.36 1.23e-11 Alzheimer's disease; CRC cis rs4363385 0.720 rs1970328 chr1:152975829 A/G cg25856811 chr1:152973957 SPRR3 -0.25 -6.76 -0.35 6.27e-11 Inflammatory skin disease; CRC cis rs1784581 0.894 rs1784594 chr6:162382734 A/G cg17173639 chr6:162384350 PARK2 -0.83 -14.75 -0.63 3.72e-38 Itch intensity from mosquito bite; CRC cis rs637571 0.522 rs566590 chr11:65754062 C/T cg02427764 chr11:65769310 BANF1;EIF1AD 0.4 5.77 0.3 1.84e-8 Eosinophil percentage of white cells; CRC cis rs3540 0.553 rs4031431 chr15:90990782 G/T cg22089800 chr15:90895588 ZNF774 0.57 9.24 0.45 3.09e-18 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; CRC cis rs10504229 1.000 rs73607875 chr8:58173522 T/C cg02290350 chr8:58132656 NA -0.42 -5.96 -0.31 6.62e-9 Developmental language disorder (linguistic errors); CRC cis rs6479527 0.875 rs10435924 chr9:96781571 T/C cg14459158 chr9:96720562 NA 0.36 6.49 0.34 3.12e-10 Esophageal adenocarcinoma; CRC cis rs4074493 1.000 rs4460622 chr1:231173033 C/T cg22172038 chr1:231176991 FAM89A 0.34 5.88 0.31 1.02e-8 Carotid plaque burden (smoking interaction); CRC cis rs4731207 0.596 rs1481333 chr7:124643059 G/T cg23710748 chr7:124431027 NA -0.39 -6.17 -0.32 1.99e-9 Cutaneous malignant melanoma; CRC cis rs4819052 0.851 rs2236446 chr21:46678985 T/C cg11663144 chr21:46675770 NA -0.7 -11.43 -0.53 1.07e-25 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs6502050 0.835 rs34199331 chr17:80134487 C/T cg13198984 chr17:80129470 CCDC57 0.47 8.08 0.41 1.26e-14 Life satisfaction; CRC cis rs10789491 1.000 rs1545206 chr1:47185082 C/G cg15501359 chr1:47185051 KIAA0494 0.73 8.59 0.43 3.57e-16 Response to hepatitis C treatment; CRC cis rs12760731 0.843 rs12023718 chr1:178491879 C/T cg00404053 chr1:178313656 RASAL2 -0.63 -7.09 -0.36 8.36e-12 Obesity-related traits; CRC cis rs1008375 0.966 rs7675735 chr4:17587137 T/A cg02297831 chr4:17616191 MED28 0.45 5.8 0.3 1.6e-8 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs11229555 0.609 rs7927730 chr11:58187906 G/A cg15696309 chr11:58395628 NA -0.81 -10.22 -0.49 1.74e-21 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; CRC cis rs17376456 0.825 rs17374166 chr5:93238655 T/C cg21475434 chr5:93447410 FAM172A 0.8 7.84 0.4 6.5e-14 Diabetic retinopathy; CRC cis rs1882538 0.564 rs12707090 chr7:133115163 G/A cg10665199 chr7:133106180 EXOC4 0.68 10.6 0.5 8.67e-23 Intelligence (multi-trait analysis); CRC cis rs826838 1.000 rs2129627 chr12:38653036 C/T cg13010199 chr12:38710504 ALG10B 0.46 6.1 0.32 2.98e-9 Heart rate; CRC cis rs4654899 0.865 rs12130841 chr1:21067051 C/T cg02927042 chr1:21476669 EIF4G3 -0.43 -6.76 -0.35 6.22e-11 Superior frontal gyrus grey matter volume; CRC cis rs644799 1.000 rs693597 chr11:95589629 T/C cg25622487 chr11:95524042 FAM76B;CEP57 0.76 11.81 0.55 4.39e-27 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs1983170 0.736 rs11164909 chr1:92002506 T/C cg22013790 chr1:91990662 CDC7 -0.47 -5.66 -0.3 3.38e-8 Eosinophil percentage of white cells; CRC cis rs4423214 1.000 rs4944957 chr11:71168035 C/T cg05163923 chr11:71159392 DHCR7 -0.63 -8.77 -0.44 9.74e-17 Vitamin D levels; CRC cis rs4728302 0.869 rs6962865 chr7:133599433 T/A cg03336402 chr7:133662267 EXOC4 -0.45 -6.5 -0.34 2.97e-10 Intelligence;Intelligence (multi-trait analysis); CRC cis rs79387448 0.745 rs72995652 chr2:103171651 C/A cg00507830 chr2:103233733 NA 0.54 6.04 0.32 4.13e-9 Gut microbiota (bacterial taxa); CRC cis rs67311347 0.955 rs11717036 chr3:40379578 G/T cg24209194 chr3:40518798 ZNF619 -0.42 -6.34 -0.33 7.79e-10 Renal cell carcinoma; CRC trans rs9393777 0.920 rs34953377 chr6:27381660 T/C cg06606381 chr12:133084897 FBRSL1 -1.02 -7.05 -0.36 1.07e-11 Intelligence (multi-trait analysis); CRC cis rs13096480 0.583 rs17598137 chr3:49891362 G/T cg01638175 chr3:49171179 LAMB2 0.43 6.94 0.36 2.15e-11 Intelligence (multi-trait analysis); CRC cis rs68170813 0.559 rs6964798 chr7:106933013 C/G cg02696742 chr7:106810147 HBP1 -0.61 -6.72 -0.35 7.94e-11 Coronary artery disease; CRC cis rs6764363 0.504 rs13072223 chr3:279586 G/C cg02057681 chr3:285234 CHL1 0.42 7.12 0.37 6.65e-12 Sudden cardiac arrest; CRC cis rs514406 0.644 rs6662414 chr1:53198893 A/G cg24675658 chr1:53192096 ZYG11B 0.74 12.1 0.55 3.9e-28 Monocyte count; CRC cis rs6062302 0.522 rs2872810 chr20:62241931 C/T cg06363034 chr20:62225388 GMEB2 0.44 6.84 0.35 3.81e-11 Glioblastoma; CRC cis rs952623 0.501 rs11973171 chr7:39086521 A/G cg18850127 chr7:39170497 POU6F2 0.46 5.91 0.31 8.42e-9 Intelligence (multi-trait analysis); CRC cis rs1355223 0.583 rs1828298 chr11:34870439 A/G cg24088639 chr11:34937564 PDHX;APIP -0.58 -8.52 -0.43 5.73e-16 Systemic lupus erythematosus and Systemic sclerosis; CRC cis rs1577917 0.655 rs6454472 chr6:86224053 T/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A 0.49 6.86 0.35 3.38e-11 Response to antipsychotic treatment; CRC cis rs6860806 0.507 rs272868 chr5:131680751 C/G cg04518342 chr5:131593106 PDLIM4 0.42 6.87 0.35 3.15e-11 Breast cancer; CRC cis rs2179367 0.887 rs2143076 chr6:149746451 G/A cg11245181 chr6:149772854 ZC3H12D -0.37 -5.85 -0.31 1.2e-8 Dupuytren's disease; CRC cis rs8077889 0.917 rs58080788 chr17:41902909 A/G cg26893861 chr17:41843967 DUSP3 0.9 12.69 0.57 2.59e-30 Triglycerides; CRC cis rs17253792 0.545 rs12894613 chr14:56016221 T/C cg01858014 chr14:56050164 KTN1 -0.89 -6.86 -0.35 3.42e-11 Putamen volume; CRC cis rs4664293 0.631 rs13024749 chr2:160656117 T/G cg08347373 chr2:160653686 CD302 0.44 7.37 0.38 1.41e-12 Monocyte percentage of white cells; CRC cis rs863345 0.564 rs11264988 chr1:158466912 A/G cg12129480 chr1:158549410 OR10X1 -0.31 -6.59 -0.34 1.78e-10 Pneumococcal bacteremia; CRC cis rs2072499 0.722 rs61462713 chr1:156161682 C/T cg25208724 chr1:156163844 SLC25A44 1.01 16.24 0.67 5.94e-44 Testicular germ cell tumor; CRC cis rs5758511 0.680 rs5758657 chr22:42618669 A/G cg00645731 chr22:42541494 CYP2D7P1 0.65 10.01 0.48 9.21e-21 Birth weight; CRC cis rs17826219 0.500 rs61685770 chr17:29085713 G/A cg01831904 chr17:28903510 LRRC37B2 -0.63 -6.45 -0.33 4.07e-10 Body mass index; CRC cis rs9916302 0.904 rs9898170 chr17:37510092 T/C cg00129232 chr17:37814104 STARD3 0.54 7.85 0.4 5.97e-14 Glomerular filtration rate (creatinine); CRC cis rs6582630 0.598 rs10880614 chr12:38509766 G/A cg13010199 chr12:38710504 ALG10B -0.41 -5.92 -0.31 8.18e-9 Drug-induced liver injury (flucloxacillin); CRC cis rs17401966 0.522 rs12133617 chr1:10288463 C/T cg19773385 chr1:10388646 KIF1B -0.48 -7.46 -0.38 7.55e-13 Hepatocellular carcinoma; CRC cis rs798554 0.757 rs1182172 chr7:2878103 G/A cg13628971 chr7:2884303 GNA12 0.52 6.89 0.36 2.8e-11 Height; CRC cis rs28386778 0.863 rs8076760 chr17:61920497 T/C cg07362569 chr17:61921086 SMARCD2 0.38 5.83 0.31 1.3e-8 Prudent dietary pattern; CRC cis rs10751667 0.643 rs7396623 chr11:934104 G/A ch.11.42038R chr11:967971 AP2A2 0.58 9.93 0.48 1.76e-20 Alzheimer's disease (late onset); CRC cis rs1451375 0.669 rs10274172 chr7:50637575 G/A cg18232548 chr7:50535776 DDC -0.46 -6.54 -0.34 2.31e-10 Malaria; CRC cis rs7264396 0.887 rs2236160 chr20:34101821 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.4 -6.31 -0.33 8.97e-10 Total cholesterol levels; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg03229959 chr8:38089560 DDHD2 0.49 6.24 0.33 1.36e-9 Thyroid stimulating hormone; CRC cis rs7258465 1.000 rs34171762 chr19:18559410 G/A cg10790698 chr19:18539756 SSBP4 -0.46 -8.84 -0.44 5.78e-17 Breast cancer; CRC cis rs61774743 0.681 rs10749805 chr1:41850182 C/T cg00290994 chr1:41848739 NA 0.52 7.87 0.4 5.2e-14 Intelligence (multi-trait analysis); CRC cis rs10504229 0.679 rs111843870 chr8:58126798 A/G cg21724239 chr8:58056113 NA 0.49 6.81 0.35 4.75e-11 Developmental language disorder (linguistic errors); CRC cis rs10504229 0.728 rs17804666 chr8:58154473 C/T cg11062466 chr8:58055876 NA 0.45 6.11 0.32 2.74e-9 Developmental language disorder (linguistic errors); CRC cis rs9393692 0.557 rs17608582 chr6:26318799 C/A cg00631329 chr6:26305371 NA -0.52 -8.72 -0.43 1.42e-16 Educational attainment; CRC trans rs1656966 1.000 rs1656966 chr3:186466252 C/T cg08354699 chr15:63796895 USP3 0.41 6.28 0.33 1.09e-9 Myopia (pathological); CRC cis rs311392 1.000 rs311392 chr8:55084782 A/G cg20636351 chr8:55087400 NA -0.32 -5.76 -0.3 1.92e-8 Pelvic organ prolapse (moderate/severe); CRC cis rs4713118 0.614 rs9380007 chr6:27660508 T/C cg03623178 chr6:28175578 NA 0.54 7.81 0.4 7.52e-14 Parkinson's disease; CRC cis rs6585424 1.000 rs34332933 chr10:81926750 G/C cg11900509 chr10:81946545 ANXA11 -0.76 -9.32 -0.46 1.78e-18 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs17666538 0.585 rs336444 chr8:633123 C/G cg13264159 chr8:625131 ERICH1 0.59 6.44 0.33 4.21e-10 IgG glycosylation; CRC cis rs739401 0.611 rs7130841 chr11:3043658 A/G cg25174290 chr11:3078921 CARS 0.47 7.34 0.38 1.67e-12 Longevity; CRC cis rs9660180 1.000 rs3737628 chr1:1722932 C/T cg03396347 chr1:1875803 NA -0.6 -9.43 -0.46 7.76e-19 Body mass index; CRC cis rs4713118 0.516 rs7739216 chr6:28079946 G/T cg12273811 chr6:28175739 NA 0.73 9.16 0.45 5.52e-18 Parkinson's disease; CRC cis rs7618501 0.602 rs34831713 chr3:50118748 T/C cg24308560 chr3:49941425 MST1R 0.5 8.31 0.42 2.51e-15 Intelligence (multi-trait analysis); CRC cis rs9303280 0.806 rs62067034 chr17:38063738 C/T cg11212589 chr17:38028394 ZPBP2 0.45 8.28 0.42 3.21e-15 Self-reported allergy; CRC cis rs853679 0.517 rs9468297 chr6:28118874 G/T cg12963246 chr6:28129442 ZNF389 0.49 5.7 0.3 2.71e-8 Depression; CRC cis rs10752881 1.000 rs10752885 chr1:182982878 C/G ch.1.3577855R chr1:183094577 LAMC1 0.86 15.19 0.64 7.68e-40 Colorectal cancer; CRC cis rs731174 0.797 rs586252 chr1:38155265 G/C cg22449745 chr1:38156939 CDCA8;C1orf109 -0.3 -5.63 -0.3 3.94e-8 Prostate cancer (SNP x SNP interaction); CRC cis rs16852403 0.517 rs12047029 chr1:178179717 C/T cg00404053 chr1:178313656 RASAL2 0.5 6.58 0.34 1.86e-10 Childhood ear infection; CRC cis rs7949030 0.591 rs35880596 chr11:62369884 C/G cg11742103 chr11:62369870 EML3;MTA2 0.62 11.34 0.53 2.25e-25 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; CRC cis rs9660180 0.934 rs34849348 chr1:1762757 C/T cg13866156 chr1:1669148 SLC35E2 -0.64 -9.66 -0.47 1.3e-19 Body mass index; CRC cis rs1007738 0.507 rs4752969 chr11:47185510 A/G cg19486271 chr11:47235900 DDB2 0.42 5.68 0.3 2.89e-8 Bone mineral density (hip); CRC cis rs1448094 0.549 rs12308898 chr12:86233678 G/A cg25456477 chr12:86230367 RASSF9 0.37 6.34 0.33 7.4e-10 Major depressive disorder; CRC cis rs2404602 0.622 rs4886506 chr15:77207277 G/T cg03037974 chr15:76606532 NA 0.55 8.45 0.42 9.42e-16 Blood metabolite levels; CRC cis rs17376456 0.825 rs10038828 chr5:93124056 C/T cg25358565 chr5:93447407 FAM172A 1.0 9.41 0.46 9.08e-19 Diabetic retinopathy; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg23633679 chr1:173793655 CENPL;DARS2 0.55 7.26 0.37 2.84e-12 Thyroid stimulating hormone; CRC cis rs10504229 0.593 rs12155520 chr8:58014318 C/T cg11062466 chr8:58055876 NA 0.53 6.58 0.34 1.85e-10 Developmental language disorder (linguistic errors); CRC trans rs951252 0.504 rs11734405 chr4:146081096 C/T cg05966498 chr5:10761293 DAP 0.49 6.68 0.35 1e-10 Hip circumference; CRC cis rs10504229 1.000 rs73609760 chr8:58192170 A/G cg05313129 chr8:58192883 C8orf71 -0.47 -6.97 -0.36 1.73e-11 Developmental language disorder (linguistic errors); CRC cis rs2842992 1.000 rs2842992 chr6:160071159 G/A cg19482086 chr6:160211437 TCP1;MRPL18 0.72 9.98 0.48 1.19e-20 Age-related macular degeneration (geographic atrophy); CRC cis rs9903692 0.954 rs8065670 chr17:46173840 G/A cg21215337 chr17:46176117 CBX1 -0.43 -7.95 -0.4 2.95e-14 Pulse pressure; CRC cis rs3018066 0.738 rs12639678 chr4:106952765 A/T cg01869342 chr4:106983673 TBCK 0.45 6.06 0.32 3.73e-9 Cancer; CRC cis rs6723226 0.739 rs2069213 chr2:32743084 C/T cg02381751 chr2:32503542 YIPF4 0.51 7.25 0.37 2.99e-12 Intelligence (multi-trait analysis); CRC trans rs4942242 0.663 rs7319346 chr13:44218201 T/C cg19169023 chr15:41853346 TYRO3 -0.58 -8.15 -0.41 7.46e-15 Response to tocilizumab in rheumatoid arthritis; CRC cis rs2075371 0.734 rs13225086 chr7:134011411 C/T cg11752832 chr7:134001865 SLC35B4 0.42 6.21 0.32 1.57e-9 Mean platelet volume; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg05045343 chr2:219232747 C2orf62 0.35 6.15 0.32 2.2e-9 Liver disease severity in Alagille syndrome; CRC cis rs992157 1.000 rs992157 chr2:219154781 A/G cg20019365 chr2:219134978 PNKD;AAMP -0.4 -6.21 -0.32 1.62e-9 Colorectal cancer; CRC cis rs7727544 0.904 rs6897575 chr5:131604535 C/T cg18301423 chr5:131593218 PDLIM4 0.31 5.82 0.31 1.4e-8 Blood metabolite levels; CRC cis rs2361718 0.500 rs12451697 chr17:78100690 T/A cg20811857 chr17:78079795 GAA -0.52 -7.94 -0.4 3.3e-14 Yeast infection; CRC cis rs7727544 0.735 rs272879 chr5:131670546 C/G cg12564285 chr5:131593104 PDLIM4 0.31 5.64 0.3 3.69e-8 Blood metabolite levels; CRC cis rs1712517 0.773 rs1063461 chr10:105049105 C/G cg05636881 chr10:105038444 INA 0.47 8.08 0.41 1.23e-14 Migraine; CRC cis rs7020830 0.928 rs11544336 chr9:37089150 A/G cg14294708 chr9:37120828 ZCCHC7 1.18 26.31 0.82 6.44e-83 Schizophrenia; CRC cis rs11203032 0.831 rs4078488 chr10:90966546 C/T cg16672925 chr10:90967113 CH25H 0.46 5.8 0.3 1.55e-8 Heart failure; CRC cis rs9399137 0.507 rs7745289 chr6:135380327 A/G cg22676075 chr6:135203613 NA 0.59 8.83 0.44 6.44e-17 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; CRC cis rs2836974 0.526 rs418359 chr21:40536734 T/C cg11644478 chr21:40555479 PSMG1 -0.72 -11.98 -0.55 1.11e-27 Cognitive function; CRC cis rs875971 0.577 rs35072105 chr7:65609817 A/G cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.39 -5.61 -0.3 4.24e-8 Aortic root size; CRC trans rs6472235 0.837 rs6996761 chr8:66911571 T/A cg07884673 chr3:53033167 SFMBT1 -0.46 -6.27 -0.33 1.11e-9 Myopia (pathological);Plateletcrit; CRC trans rs2018683 1.000 rs2018683 chr7:29014195 G/T cg19402173 chr7:128379420 CALU -0.58 -9.13 -0.45 7.28e-18 Response to irinotecan and platinum-based chemotherapy in non-small-cell lung cancer; CRC cis rs9462027 0.628 rs2395598 chr6:34640686 T/C cg07306190 chr6:34760872 UHRF1BP1 -0.35 -6.32 -0.33 8.5e-10 Systemic lupus erythematosus; CRC cis rs11098499 0.954 rs4309825 chr4:120314881 C/T cg09307838 chr4:120376055 NA -0.69 -10.34 -0.5 6.93e-22 Corneal astigmatism; CRC cis rs11098499 0.863 rs1010740 chr4:120463409 C/T cg24375607 chr4:120327624 NA -0.49 -7.64 -0.39 2.34e-13 Corneal astigmatism; CRC cis rs9322193 0.884 rs9480009 chr6:150079638 A/G cg07701084 chr6:150067640 NUP43 0.59 8.71 0.43 1.48e-16 Lung cancer; CRC cis rs6499255 1.000 rs4985518 chr16:69787158 T/C cg04110750 chr16:69646130 NFAT5 -0.51 -6.75 -0.35 6.72e-11 IgE levels; CRC cis rs9926296 0.527 rs1800335 chr16:89846195 A/G cg04287289 chr16:89883240 FANCA 0.82 15.06 0.64 2.47e-39 Vitiligo; CRC cis rs12692738 0.526 rs355853 chr2:165627618 T/C cg03182029 chr2:165697222 COBLL1 0.5 5.86 0.31 1.11e-8 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);Waist-to-hip ratio adjusted for BMI in non-smokers;Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction);Waist-to-hip ratio adjusted for body mass index; CRC cis rs35146811 0.696 rs1727124 chr7:99804104 T/G cg00553149 chr7:99775558 STAG3;GPC2 -0.26 -6.16 -0.32 2.11e-9 Coronary artery disease; CRC cis rs561341 0.831 rs11658469 chr17:30206426 T/C cg13647721 chr17:30228624 UTP6 -0.57 -5.9 -0.31 9.26e-9 Hip circumference adjusted for BMI; CRC trans rs9929218 0.954 rs9923925 chr16:68819444 G/A cg04657470 chr2:198365150 HSPE1;HSPD1 -0.8 -11.19 -0.53 7.33e-25 Colorectal cancer; CRC cis rs6662572 0.737 rs4423055 chr1:46259980 T/C cg08644498 chr1:46502608 NA -0.44 -7.0 -0.36 1.4e-11 Blood protein levels; CRC cis rs6546550 0.901 rs897119 chr2:70160658 T/C cg02498382 chr2:70120550 SNRNP27 -0.56 -9.54 -0.47 3.23e-19 Prevalent atrial fibrillation; CRC cis rs2070488 0.804 rs1870914 chr3:38494220 T/C cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.73 12.65 0.57 3.69e-30 Electrocardiographic conduction measures; CRC cis rs2976388 0.609 rs2572909 chr8:143806464 C/G cg15511327 chr8:143859410 LYNX1 0.39 6.87 0.35 3.13e-11 Urinary tract infection frequency; CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg26313349 chr1:145589328 NUDT17 0.36 6.01 0.31 4.8e-9 Obesity-related traits; CRC cis rs2282802 0.685 rs13359519 chr5:139654664 G/A cg26211634 chr5:139558579 C5orf32 0.43 7.39 0.38 1.26e-12 Intelligence (multi-trait analysis); CRC cis rs7618915 0.547 rs4130905 chr3:52709831 A/T cg11645453 chr3:52864694 ITIH4 0.37 6.41 0.33 4.91e-10 Bipolar disorder; CRC cis rs853679 0.550 rs6901017 chr6:28152583 T/C cg23161317 chr6:28129485 ZNF389 0.52 6.62 0.34 1.49e-10 Depression; CRC cis rs4926298 1.000 rs10423745 chr19:13176815 T/C cg23899408 chr19:12877188 HOOK2 -0.45 -6.33 -0.33 8.13e-10 Bipolar disorder; CRC cis rs7666738 0.800 rs7684523 chr4:98983175 G/T cg17366294 chr4:99064904 C4orf37 0.43 7.33 0.37 1.76e-12 Colonoscopy-negative controls vs population controls; CRC cis rs172166 0.561 rs149973 chr6:27983613 G/T cg15786705 chr6:28176104 NA 0.47 6.9 0.36 2.66e-11 Cardiac Troponin-T levels; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg00029397 chr12:57940957 DCTN2 0.48 6.33 0.33 8.12e-10 Thyroid stimulating hormone; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg20652787 chr6:41863119 USP49 0.39 6.35 0.33 7.25e-10 Liver disease severity in Alagille syndrome; CRC cis rs1050846 0.603 rs1050847 chr16:87443734 A/G cg27585878 chr16:87386489 FBXO31 0.43 7.13 0.37 6.59e-12 Neuroticism; CRC cis rs9494142 0.592 rs1547247 chr6:135390836 C/T cg22676075 chr6:135203613 NA 0.76 10.92 0.52 6.64e-24 Lymphocyte counts;Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs10256972 0.568 rs1133043 chr7:1133305 C/G cg22907277 chr7:1156413 C7orf50 0.74 11.74 0.54 8.14e-27 Longevity;Endometriosis; CRC cis rs9487051 0.773 rs351749 chr6:109533353 A/T cg21918786 chr6:109611834 NA -0.36 -6.18 -0.32 1.85e-9 Reticulocyte fraction of red cells; CRC cis rs4727027 0.625 rs75129390 chr7:148846775 T/A cg23583168 chr7:148888333 NA -0.86 -13.85 -0.61 1.1e-34 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC cis rs9462027 0.628 rs2814957 chr6:34702689 C/G cg07306190 chr6:34760872 UHRF1BP1 -0.34 -6.07 -0.32 3.49e-9 Systemic lupus erythematosus; CRC cis rs1799949 1.000 rs8176126 chr17:41259049 A/G cg25072359 chr17:41440525 NA -0.46 -6.93 -0.36 2.27e-11 Menopause (age at onset); CRC cis rs9814567 1.000 rs62269547 chr3:134214042 T/C cg06109529 chr3:134205091 CEP63;ANAPC13 -0.81 -12.26 -0.56 1e-28 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs10919791 0.501 rs12029406 chr1:199905828 A/G cg13229857 chr1:200006247 NR5A2 -0.43 -6.46 -0.34 3.88e-10 Pancreatic cancer; CRC cis rs916888 0.821 rs199506 chr17:44859031 A/G cg01570182 chr17:44337453 NA -1.08 -12.81 -0.58 9.04e-31 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs1218582 0.741 rs11264283 chr1:154869552 A/G cg24250549 chr1:154909240 PMVK 0.65 11.13 0.52 1.27e-24 Prostate cancer; CRC cis rs1555322 0.530 rs2425047 chr20:33871675 G/T cg03689076 chr20:33865952 NA -0.49 -7.14 -0.37 6.06e-12 Attention deficit hyperactivity disorder; CRC cis rs17376456 0.825 rs6874766 chr5:93213807 C/G cg09848695 chr5:92956644 FAM172A;MIR2277 -0.68 -5.95 -0.31 6.74e-9 Diabetic retinopathy; CRC cis rs939584 1.000 rs13386517 chr2:650479 G/C cg03610516 chr2:642275 NA -0.42 -5.89 -0.31 9.71e-9 Body mass index; CRC cis rs1545257 0.538 rs729921 chr2:24633124 T/G cg06627628 chr2:24431161 ITSN2 -0.45 -6.63 -0.34 1.34e-10 Sjögren's syndrome; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg11940663 chr21:46962454 SLC19A1 0.43 6.85 0.35 3.56e-11 Liver disease severity in Alagille syndrome; CRC cis rs4731207 0.698 rs12538333 chr7:124508357 T/C cg23710748 chr7:124431027 NA -0.38 -6.08 -0.32 3.42e-9 Cutaneous malignant melanoma; CRC cis rs9733 0.596 rs2867301 chr1:150653795 C/T cg17724175 chr1:150552817 MCL1 0.58 9.4 0.46 9.25e-19 Tonsillectomy; CRC cis rs2011503 0.943 rs2965195 chr19:19463032 A/G cg11584989 chr19:19387371 SF4 -0.47 -5.91 -0.31 8.49e-9 Bipolar disorder; CRC cis rs7937682 0.883 rs484834 chr11:111465761 G/C cg09085632 chr11:111637200 PPP2R1B -0.94 -17.74 -0.7 7.01e-50 Primary sclerosing cholangitis; CRC cis rs4144743 0.759 rs16969966 chr17:45318452 G/T cg18085866 chr17:45331354 ITGB3 -0.52 -6.48 -0.34 3.25e-10 Body mass index; CRC cis rs6502050 0.764 rs35713597 chr17:80119016 C/G cg11859384 chr17:80120422 CCDC57 -0.36 -5.75 -0.3 2.06e-8 Life satisfaction; CRC cis rs6681460 0.899 rs1280280 chr1:67173903 G/A cg02459107 chr1:67143332 SGIP1 0.34 5.88 0.31 1.03e-8 Presence of antiphospholipid antibodies; CRC trans rs13046373 0.905 rs4816372 chr21:32077414 A/T cg03748352 chr10:182365 ZMYND11 -0.42 -6.28 -0.33 1.09e-9 HDL cholesterol; CRC cis rs709400 0.628 rs72708854 chr14:103864885 T/C cg12935359 chr14:103987150 CKB -0.52 -7.79 -0.39 8.56e-14 Body mass index; CRC cis rs7258465 0.896 rs8103660 chr19:18566395 T/C cg06462663 chr19:18546047 ISYNA1 0.48 7.28 0.37 2.43e-12 Breast cancer; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg21190381 chr2:53994763 LOC100302652;ASB3;CHAC2 0.42 6.21 0.32 1.58e-9 Intelligence (multi-trait analysis); CRC cis rs2274273 0.588 rs11158037 chr14:55832152 C/A cg10130446 chr14:55658398 DLGAP5 -0.43 -6.03 -0.32 4.48e-9 Protein biomarker; CRC cis rs6952808 0.594 rs3778965 chr7:2138296 G/A cg22963979 chr7:1858916 MAD1L1 -0.46 -6.63 -0.34 1.36e-10 Bipolar disorder and schizophrenia; CRC cis rs1799949 1.000 rs8077486 chr17:41212805 C/T cg05368731 chr17:41323189 NBR1 0.62 9.45 0.46 6.67e-19 Menopause (age at onset); CRC trans rs3960554 0.569 rs11973658 chr7:75882026 A/C cg19862616 chr7:65841803 NCRNA00174 0.56 8.31 0.42 2.61e-15 Eotaxin levels; CRC cis rs72945132 0.882 rs2276001 chr11:70181560 T/C cg00319359 chr11:70116639 PPFIA1 0.65 7.24 0.37 3.14e-12 Coronary artery disease; CRC cis rs11758351 0.866 rs55815656 chr6:26207303 G/A cg08260959 chr6:26240920 HIST1H4F -0.35 -5.77 -0.3 1.81e-8 Gout;Renal underexcretion gout; CRC cis rs9487051 0.676 rs6903107 chr6:109597711 A/G cg21918786 chr6:109611834 NA -0.41 -7.17 -0.37 4.84e-12 Reticulocyte fraction of red cells; CRC cis rs7944584 0.551 rs12224672 chr11:47500400 C/T cg20307385 chr11:47447363 PSMC3 0.82 11.61 0.54 2.44e-26 Fasting blood glucose;Fasting blood glucose (BMI interaction); CRC cis rs4713118 0.869 rs6914924 chr6:27711530 C/T cg26587870 chr6:27730563 NA -0.43 -6.72 -0.35 8.04e-11 Parkinson's disease; CRC cis rs10751667 0.580 rs11246363 chr11:971667 T/C cg06064525 chr11:970664 AP2A2 -0.3 -6.07 -0.32 3.54e-9 Alzheimer's disease (late onset); CRC cis rs3741404 0.672 rs4980524 chr11:63959259 A/C cg18225595 chr11:63971243 STIP1 0.53 8.69 0.43 1.75e-16 Platelet count; CRC cis rs10256972 0.552 rs2949192 chr7:1203841 C/T cg23708337 chr7:1209742 NA 0.49 7.58 0.39 3.45e-13 Longevity;Endometriosis; CRC cis rs7705042 0.865 rs12656877 chr5:141490091 T/C cg07392085 chr5:141489673 NDFIP1 0.47 7.25 0.37 2.95e-12 Asthma; CRC cis rs561341 1.000 rs68140514 chr17:30335781 T/C cg23018236 chr17:30244563 NA -0.6 -7.82 -0.4 7.2e-14 Hip circumference adjusted for BMI; CRC cis rs7613875 0.543 rs34034116 chr3:49959156 C/A cg05623727 chr3:50126028 RBM5 0.62 10.56 0.5 1.25e-22 Body mass index; CRC trans rs116095464 0.558 rs7714335 chr5:263513 T/C cg00938859 chr5:1591904 SDHAP3 0.7 7.62 0.39 2.78e-13 Breast cancer; CRC cis rs2629540 0.781 rs2293064 chr10:126396511 C/G cg08799069 chr10:126477246 METTL10 0.46 5.95 0.31 6.73e-9 Cocaine dependence; CRC cis rs796364 0.568 rs11890894 chr2:201072055 C/T cg23649088 chr2:200775458 C2orf69 0.49 6.15 0.32 2.28e-9 Schizophrenia; CRC cis rs7923609 1.000 rs10761742 chr10:65085048 A/G cg08743896 chr10:65200160 JMJD1C -0.4 -5.78 -0.3 1.73e-8 Educational attainment;Liver enzyme levels (alkaline phosphatase); CRC cis rs10791097 0.694 rs1050071 chr11:130747231 C/G cg12179176 chr11:130786555 SNX19 0.75 12.16 0.56 2.41e-28 Autism spectrum disorder or schizophrenia;Schizophrenia; CRC trans rs7710178 0.680 rs280462 chr5:156043586 G/A cg05270082 chr4:166307089 MIR578;CPE 0.43 5.97 0.31 6.04e-9 Airway responsiveness in chronic obstructive pulmonary disease; CRC cis rs514406 0.679 rs11206006 chr1:53218380 A/G cg27535305 chr1:53392650 SCP2 0.46 8.19 0.41 6e-15 Monocyte count; CRC cis rs7618915 0.547 rs10865973 chr3:52718154 A/T cg18099408 chr3:52552593 STAB1 -0.44 -7.16 -0.37 5.27e-12 Bipolar disorder; CRC trans rs1455244 0.700 rs7229302 chr18:11508904 G/T cg15447715 chr7:150725397 ABCB8 0.45 6.82 0.35 4.34e-11 Schizophrenia; CRC cis rs6762 0.719 rs1130698 chr11:838542 C/T cg03116740 chr11:841335 TSPAN4;POLR2L -0.42 -6.89 -0.36 2.79e-11 Mean platelet volume; CRC cis rs7119 0.717 rs8042307 chr15:77804013 A/G cg10437265 chr15:77819839 NA 0.65 11.54 0.54 4.4e-26 Type 2 diabetes; CRC cis rs1957429 0.731 rs28370916 chr14:65346094 A/G cg23373153 chr14:65346875 NA 0.82 8.19 0.41 5.86e-15 Pediatric areal bone mineral density (radius); CRC cis rs7208859 0.673 rs9894876 chr17:29182020 G/A cg01831904 chr17:28903510 LRRC37B2 -0.55 -5.72 -0.3 2.33e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs9879311 0.966 rs28113 chr3:10400643 G/A cg11030744 chr3:10328490 GHRL;GHRLOS 0.38 6.25 0.33 1.25e-9 Schizophrenia;Autism spectrum disorder or schizophrenia; CRC cis rs3818285 0.556 rs2084607 chr10:111681411 C/T cg00817464 chr10:111662876 XPNPEP1 0.49 6.82 0.35 4.29e-11 Superior crus of antihelix expression; CRC cis rs12134245 0.776 rs61548854 chr1:92001536 C/T cg02896835 chr1:92012615 NA -0.65 -11.78 -0.54 6.03e-27 Breast cancer; CRC cis rs17767294 0.611 rs66487884 chr6:28202912 C/G cg06470822 chr6:28175283 NA 0.88 8.32 0.42 2.3e-15 Parkinson's disease; CRC cis rs1348850 0.914 rs12469386 chr2:178358281 A/G cg22681709 chr2:178499509 PDE11A 0.35 6.44 0.33 4.28e-10 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs1707322 1.000 rs10789485 chr1:46407308 C/T cg03146154 chr1:46216737 IPP 0.58 8.13 0.41 9.05e-15 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs7085104 0.684 rs7092690 chr10:104609365 T/C cg08772003 chr10:104629869 AS3MT -0.35 -6.02 -0.32 4.59e-9 Immature fraction of reticulocytes;Schizophrenia; CRC cis rs7727544 0.582 rs3805683 chr5:131535125 T/G cg18758796 chr5:131593413 PDLIM4 0.33 5.64 0.3 3.59e-8 Blood metabolite levels; CRC cis rs798554 0.679 rs13230995 chr7:2887284 G/A cg19346786 chr7:2764209 NA -0.37 -6.43 -0.33 4.4e-10 Height; CRC cis rs4629710 0.568 rs67021539 chr6:131552900 A/G cg12606694 chr6:131520996 AKAP7 0.56 8.29 0.42 3.02e-15 Multiple myeloma (IgH translocation); CRC cis rs12908161 1.000 rs36033486 chr15:85319692 A/G cg17507749 chr15:85114479 UBE2QP1 0.62 8.97 0.44 2.36e-17 Schizophrenia; CRC cis rs1983170 0.668 rs77687738 chr1:92016191 C/G cg21854759 chr1:92012499 NA 0.5 5.63 0.3 3.91e-8 Eosinophil percentage of white cells; CRC cis rs60871478 0.704 rs62432895 chr7:822050 C/G cg04727924 chr7:799746 HEATR2 -0.43 -6.36 -0.33 6.92e-10 Cerebrospinal P-tau181p levels; CRC cis rs9768139 0.935 rs10155946 chr7:158122116 C/T cg24154853 chr7:158122151 PTPRN2 -0.61 -10.07 -0.49 5.72e-21 Calcium levels; CRC cis rs6834538 0.637 rs923237 chr4:113429731 C/G cg10021238 chr4:113569128 MIR367;LARP7 -0.4 -5.98 -0.31 5.97e-9 Free thyroxine concentration; CRC cis rs763014 0.932 rs34498660 chr16:666149 A/G cg04562611 chr16:615315 C16orf11 0.37 6.32 0.33 8.54e-10 Height; CRC cis rs12936587 0.692 rs35660942 chr17:17527185 G/A cg09796270 chr17:17721594 SREBF1 -0.4 -5.88 -0.31 9.95e-9 Hip circumference;Coronary artery disease or large artery stroke;Coronary heart disease;Coronary artery disease; CRC cis rs12188164 0.686 rs72711369 chr5:420517 C/T cg17553881 chr5:443987 EXOC3;C5orf55 -0.36 -7.41 -0.38 1.05e-12 Cystic fibrosis severity; CRC cis rs1018836 0.923 rs7833025 chr8:91568470 G/C cg16814680 chr8:91681699 NA -0.74 -11.74 -0.54 8.39e-27 Ejection fraction in Tripanosoma cruzi seropositivity; CRC trans rs2303319 0.582 rs56094729 chr2:162464835 C/T cg12500891 chr11:57225987 NA -0.68 -6.07 -0.32 3.55e-9 Cognitive function; CRC cis rs11785400 1.000 rs754957 chr8:143746416 A/G cg24634471 chr8:143751801 JRK 0.53 7.55 0.38 4.42e-13 Schizophrenia; CRC trans rs2303319 0.504 rs56009150 chr2:162598582 T/C cg26358599 chr1:24018029 RPL11 -0.74 -6.02 -0.31 4.71e-9 Cognitive function; CRC trans rs7395662 0.591 rs4882138 chr11:48619321 A/G cg21153622 chr11:89784906 NA -0.52 -8.68 -0.43 1.92e-16 HDL cholesterol; CRC cis rs370915 0.542 rs6838849 chr4:187790684 T/C cg12892747 chr4:187813459 NA -0.41 -6.2 -0.32 1.67e-9 Gout; CRC cis rs6502050 0.835 rs8080423 chr17:80102279 A/G cg09264619 chr17:80180166 NA -0.34 -5.81 -0.3 1.5e-8 Life satisfaction; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg18887142 chr20:47835750 DDX27 0.41 6.15 0.32 2.2e-9 Liver disease severity in Alagille syndrome; CRC cis rs9527 0.590 rs7917650 chr10:104937100 G/C cg15744005 chr10:104629667 AS3MT -0.3 -5.97 -0.31 6.07e-9 Arsenic metabolism; CRC cis rs6500395 1.000 rs9928051 chr16:48557316 T/A cg04672837 chr16:48644449 N4BP1 0.39 5.61 0.3 4.28e-8 Response to tocilizumab in rheumatoid arthritis; CRC cis rs929354 0.772 rs1182362 chr7:157019535 A/G cg17757837 chr7:157058334 UBE3C -0.76 -12.96 -0.58 2.5e-31 Body mass index; CRC cis rs523522 0.962 rs2235218 chr12:120888619 A/C cg27279351 chr12:120934652 DYNLL1 0.73 10.69 0.51 4.25e-23 High light scatter reticulocyte count; CRC trans rs11764590 0.724 rs1533829 chr7:2082841 A/G cg11693508 chr17:37793320 STARD3 0.46 6.19 0.32 1.8e-9 Neuroticism; CRC cis rs17666538 1.000 rs61064968 chr8:587933 T/C cg07685180 chr8:600429 NA -0.81 -7.53 -0.38 4.99e-13 IgG glycosylation; CRC cis rs11650776 1 rs11650776 chr17:37641402 G/A cg15445000 chr17:37608096 MED1 0.42 9.27 0.46 2.47e-18 Lung function (FEV1); CRC trans rs3858526 0.917 rs10769386 chr11:5973420 C/T cg01505111 chr6:125621795 HDDC2 -0.39 -6.0 -0.31 5.07e-9 DNA methylation (variation); CRC cis rs1348850 0.651 rs4893936 chr2:178240676 C/G cg02961200 chr2:178257176 LOC100130691;AGPS 0.48 6.7 0.35 9.14e-11 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs9611565 0.512 rs9607842 chr22:42192722 G/A cg03806693 chr22:41940476 POLR3H -1.09 -13.4 -0.59 5.76e-33 Vitiligo; CRC cis rs12477438 0.798 rs10196680 chr2:99628617 A/G cg26064155 chr2:99771622 LIPT1;TSGA10 -0.79 -11.23 -0.53 5.3e-25 Chronic sinus infection; CRC cis rs4481887 0.741 rs6421453 chr1:248533285 A/G cg26353448 chr1:248524236 OR2T4 -0.35 -6.68 -0.35 1.02e-10 Common traits (Other); CRC cis rs62229266 0.609 rs2835253 chr21:37419745 T/C cg08632701 chr21:37451849 NA -0.4 -6.27 -0.33 1.14e-9 Mitral valve prolapse; CRC cis rs62458065 0.850 rs7804998 chr7:32461197 T/C cg20159608 chr7:32802032 NA -0.54 -6.62 -0.34 1.47e-10 Metabolite levels (HVA/MHPG ratio); CRC trans rs7618501 0.602 rs2240326 chr3:50128386 G/A cg21665057 chr3:196295764 WDR53;FBXO45 -0.62 -9.86 -0.48 2.97e-20 Intelligence (multi-trait analysis); CRC cis rs9660180 1.000 rs9660180 chr1:1723031 G/A cg13866156 chr1:1669148 SLC35E2 -0.61 -9.46 -0.46 6.24e-19 Body mass index; CRC cis rs3741404 0.537 rs1123251 chr11:63917601 G/T cg18225595 chr11:63971243 STIP1 -0.43 -6.65 -0.34 1.19e-10 Platelet count; CRC cis rs2797160 0.967 rs8180614 chr6:126000599 G/C cg05901451 chr6:126070800 HEY2 -0.38 -5.93 -0.31 7.46e-9 Endometrial cancer; CRC cis rs1577917 1.000 rs12190598 chr6:86686074 C/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.55 -7.09 -0.36 8.03e-12 Response to antipsychotic treatment; CRC cis rs853679 1.000 rs2799079 chr6:28235176 A/C cg06470822 chr6:28175283 NA 0.63 6.69 0.35 9.4e-11 Depression; CRC cis rs10540 1.000 rs12786555 chr11:506229 C/T cg08200582 chr11:442649 ANO9 -0.71 -7.44 -0.38 8.72e-13 Body mass index; CRC cis rs9322193 0.884 rs10872647 chr6:150079823 T/C cg05861140 chr6:150128134 PCMT1 -0.42 -6.48 -0.34 3.31e-10 Lung cancer; CRC cis rs78456975 0.943 rs13391932 chr2:1577679 T/C cg26248373 chr2:1572462 NA -0.68 -8.31 -0.42 2.63e-15 Placebo response in major depressive disorder (% change in symptom score); CRC cis rs1538970 1.000 rs1538970 chr1:45847562 G/A cg05343316 chr1:45956843 TESK2 0.69 8.99 0.44 2.01e-17 Platelet count; CRC cis rs1008375 0.863 rs2058336 chr4:17608299 T/C cg16339924 chr4:17578868 LAP3 0.47 6.22 0.32 1.52e-9 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs9649213 0.593 rs7787858 chr7:98009914 T/C cg24562669 chr7:97807699 LMTK2 0.43 7.15 0.37 5.5e-12 Prostate cancer (SNP x SNP interaction); CRC cis rs11098499 0.644 rs10009566 chr4:120558608 A/G cg24375607 chr4:120327624 NA 0.44 7.02 0.36 1.25e-11 Corneal astigmatism; CRC trans rs561341 1.000 rs498391 chr17:30328704 G/A cg20587970 chr11:113659929 NA -1.42 -20.2 -0.74 1.38e-59 Hip circumference adjusted for BMI; CRC cis rs2243480 1.000 rs313813 chr7:65503500 C/T cg18252515 chr7:66147081 NA -1.18 -13.17 -0.59 4e-32 Diabetic kidney disease; CRC cis rs950027 0.787 rs1547487 chr15:45723983 A/G cg21132104 chr15:45694354 SPATA5L1 0.44 6.43 0.33 4.42e-10 Response to fenofibrate (adiponectin levels); CRC trans rs10982213 0.830 rs2274163 chr9:117188714 C/T cg21501234 chr15:64683155 TRIP4 0.45 6.68 0.35 1e-10 Interleukin-6 levels; CRC cis rs4380275 0.965 rs4375894 chr2:772567 G/C cg27237671 chr2:676223 TMEM18 -0.41 -5.72 -0.3 2.41e-8 Adverse response to chemotherapy (neutropenia/leucopenia) (doxorubicin); CRC cis rs950776 0.714 rs514743 chr15:78884227 A/T cg06917634 chr15:78832804 PSMA4 -0.53 -8.21 -0.41 5.25e-15 Sudden cardiac arrest; CRC cis rs9549260 0.755 rs9532579 chr13:41243458 T/C cg21288729 chr13:41239152 FOXO1 0.48 7.44 0.38 8.57e-13 Red blood cell count; CRC cis rs367943 1.000 rs348957 chr5:112821178 C/T cg12552261 chr5:112820674 MCC 0.49 7.59 0.39 3.23e-13 Type 2 diabetes; CRC cis rs10504229 0.683 rs61241336 chr8:58106585 A/G cg02290350 chr8:58132656 NA -0.59 -8.02 -0.4 1.88e-14 Developmental language disorder (linguistic errors); CRC cis rs10540 0.915 rs35389167 chr11:460765 A/G cg21784768 chr11:537496 LRRC56 -0.59 -5.64 -0.3 3.67e-8 Body mass index; CRC trans rs875971 0.528 rs801213 chr7:66014918 C/T cg02869306 chr7:64672164 INTS4L1 0.43 6.28 0.33 1.08e-9 Aortic root size; CRC trans rs7726839 0.540 rs7558 chr5:660491 C/T cg11887960 chr12:57824829 NA 0.65 7.25 0.37 3.08e-12 Obesity-related traits; CRC trans rs11098499 0.691 rs9307471 chr4:120261262 G/A cg25214090 chr10:38739885 LOC399744 0.55 9.02 0.45 1.61e-17 Corneal astigmatism; CRC cis rs853679 0.517 rs9368558 chr6:28133306 A/G cg06470822 chr6:28175283 NA 1.03 13.59 0.6 1.04e-33 Depression; CRC cis rs7224685 0.530 rs7221574 chr17:4007543 T/C cg05562828 chr17:3906858 NA 0.48 6.29 0.33 1e-9 Type 2 diabetes; CRC cis rs7215564 0.908 rs61707349 chr17:78665255 T/C cg09596252 chr17:78655493 RPTOR 0.55 6.13 0.32 2.57e-9 Myopia (pathological); CRC cis rs523522 0.962 rs10849759 chr12:120994488 T/A cg27279351 chr12:120934652 DYNLL1 0.76 11.06 0.52 2.15e-24 High light scatter reticulocyte count; CRC cis rs7264396 0.790 rs6060565 chr20:34285442 C/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.63 -10.71 -0.51 3.59e-23 Total cholesterol levels; CRC cis rs367615 0.704 rs55956735 chr5:108845042 A/G cg17395555 chr5:108820864 NA 0.46 9.35 0.46 1.4e-18 Colorectal cancer (SNP x SNP interaction); CRC cis rs7618501 0.633 rs55751738 chr3:49972101 A/G cg24110177 chr3:50126178 RBM5 -0.49 -7.54 -0.38 4.68e-13 Intelligence (multi-trait analysis); CRC cis rs2243480 1.000 rs2707831 chr7:66062511 G/A cg12463550 chr7:65579703 CRCP 0.66 6.0 0.31 5.22e-9 Diabetic kidney disease; CRC cis rs4957048 0.891 rs11960196 chr5:568857 C/A cg09021430 chr5:549028 NA -0.84 -11.01 -0.52 3.21e-24 Ulcerative colitis; CRC cis rs57221529 0.766 rs72703042 chr5:579269 C/T cg17948913 chr5:572064 NA 0.56 6.25 0.33 1.28e-9 Lung disease severity in cystic fibrosis; CRC cis rs4665809 1.000 rs4665304 chr2:26313406 C/T cg04944784 chr2:26401820 FAM59B -0.6 -7.92 -0.4 3.73e-14 Gut microbiome composition (summer); CRC cis rs9921222 0.502 rs28461430 chr16:369562 G/A cg00101154 chr16:420108 MRPL28 -0.59 -7.51 -0.38 5.49e-13 Bone mineral density (spine);Bone mineral density; CRC cis rs11608355 0.545 rs4766475 chr12:109908373 G/A cg05360138 chr12:110035743 NA 0.78 8.75 0.43 1.15e-16 Neuroticism; CRC cis rs8177253 0.665 rs9831392 chr3:133451473 A/T cg24879335 chr3:133465180 TF 0.37 6.81 0.35 4.56e-11 Iron status biomarkers; CRC cis rs41005 1.000 rs798449 chr2:8106533 G/A cg03155496 chr2:8117019 LOC339788 0.41 7.18 0.37 4.69e-12 Response to anti-TNF therapy in rheumatoid arthritis; CRC cis rs9660180 0.868 rs72634846 chr1:1704915 C/G cg03396347 chr1:1875803 NA -0.6 -9.25 -0.45 2.96e-18 Body mass index; CRC cis rs4713118 0.621 rs4713134 chr6:28034121 T/C cg03623178 chr6:28175578 NA 0.89 11.83 0.55 3.94e-27 Parkinson's disease; CRC trans rs9858542 0.903 rs11921590 chr3:49644193 T/C cg21659725 chr3:3221576 CRBN -0.74 -9.68 -0.47 1.12e-19 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs3204270 0.530 rs57707013 chr17:79635281 C/T cg09655341 chr17:79618100 PDE6G 0.49 5.95 0.31 6.78e-9 Dental caries; CRC cis rs7772486 0.641 rs67882056 chr6:146416301 T/C cg23711669 chr6:146136114 FBXO30 0.56 8.02 0.4 1.83e-14 Lobe attachment (rater-scored or self-reported); CRC cis rs2354432 0.556 rs12568866 chr1:146718430 A/C cg25205988 chr1:146714368 CHD1L -1.17 -10.08 -0.49 5.18e-21 Mitochondrial DNA levels; CRC cis rs7487075 1.000 rs10880966 chr12:46801782 C/G cg17501823 chr12:47219793 SLC38A4 0.32 5.64 0.3 3.58e-8 Itch intensity from mosquito bite; CRC trans rs1005277 0.579 rs2474574 chr10:38387295 C/T cg17830980 chr10:43048298 ZNF37B -0.6 -9.96 -0.48 1.3e-20 Extrinsic epigenetic age acceleration; CRC cis rs7647973 0.566 rs57630346 chr3:49086215 T/C cg07636037 chr3:49044803 WDR6 0.88 10.92 0.52 6.63e-24 Menarche (age at onset); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg01786828 chr11:9685521 SWAP70 0.49 6.68 0.35 1.01e-10 Response to antipsychotic treatment; CRC cis rs7666738 0.924 rs11097592 chr4:98927532 C/T cg03676636 chr4:99064102 C4orf37 0.24 6.66 0.34 1.17e-10 Colonoscopy-negative controls vs population controls; CRC cis rs13191362 1.000 rs13201023 chr6:162981381 C/G cg21926612 chr6:163149169 PACRG;PARK2 0.84 11.95 0.55 1.44e-27 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs990171 0.607 rs10153578 chr2:102764609 C/T cg22835712 chr2:102737379 NA -0.44 -5.68 -0.3 2.9e-8 Lymphocyte counts; CRC cis rs7725052 0.609 rs4532399 chr5:40467272 T/C cg09067459 chr5:40385259 NA 0.4 6.57 0.34 1.94e-10 Pediatric autoimmune diseases; CRC cis rs754466 0.606 rs12356375 chr10:79594514 C/A cg26805224 chr10:79626177 DLG5 -0.5 -7.18 -0.37 4.67e-12 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs873946 0.586 rs3829130 chr10:134563122 C/T cg26818010 chr10:134567672 INPP5A -0.71 -9.09 -0.45 9.28e-18 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CRC cis rs758324 0.947 rs4705903 chr5:131206594 A/C cg06307176 chr5:131281290 NA 0.41 6.23 0.32 1.46e-9 Alzheimer's disease in APOE e4- carriers; CRC cis rs4975709 0.589 rs4975747 chr5:1862836 G/A cg15595755 chr5:1867978 NA 0.38 6.44 0.33 4.17e-10 Cardiovascular disease risk factors; CRC trans rs2710642 0.779 rs360807 chr2:62926859 C/T cg05376469 chr2:102649931 NA 0.37 6.04 0.32 4.2e-9 LDL cholesterol levels;LDL cholesterol; CRC cis rs3204270 0.543 rs34034499 chr17:79638568 G/C cg09655341 chr17:79618100 PDE6G 0.5 6.32 0.33 8.48e-10 Dental caries; CRC cis rs6840360 0.593 rs6855883 chr4:152688997 A/G cg09659197 chr4:152720779 NA 0.41 8.46 0.42 8.74e-16 Intelligence (multi-trait analysis); CRC cis rs568617 0.953 rs645900 chr11:65648135 G/A cg19792802 chr11:65647270 CTSW -0.5 -7.55 -0.38 4.23e-13 Crohn's disease; CRC cis rs11098499 0.909 rs2127821 chr4:120394535 T/C cg09307838 chr4:120376055 NA 0.71 11.09 0.52 1.73e-24 Corneal astigmatism; CRC cis rs6461049 0.638 rs3778994 chr7:2175855 G/T cg04267008 chr7:1944627 MAD1L1 -0.45 -6.49 -0.34 3.2e-10 Schizophrenia; CRC cis rs7523050 0.643 rs35907086 chr1:109406625 A/G cg08274380 chr1:109419600 GPSM2 0.9 6.76 0.35 6.12e-11 Fat distribution (HIV); CRC trans rs1005277 0.579 rs2472182 chr10:38388865 T/C cg17830980 chr10:43048298 ZNF37B -0.6 -9.96 -0.48 1.3e-20 Extrinsic epigenetic age acceleration; CRC cis rs877282 0.842 rs7092986 chr10:756373 G/A cg17470449 chr10:769945 NA 0.61 7.96 0.4 2.78e-14 Uric acid levels; CRC cis rs9992667 0.955 rs10025499 chr4:38620994 T/C cg19726192 chr4:38663646 FLJ13197 -0.6 -7.79 -0.39 9.02e-14 Eosinophil percentage of granulocytes; CRC cis rs11212617 0.967 rs7118967 chr11:108057856 G/A cg01991180 chr11:108092276 ATM;NPAT 0.41 6.16 0.32 2.16e-9 Response to metformin in type 2 diabetes (glycemic); CRC cis rs9303401 0.614 rs35245220 chr17:56510305 G/A cg10487724 chr17:56770010 TEX14;RAD51C 0.74 8.5 0.42 6.71e-16 Cognitive test performance; CRC cis rs782590 0.643 rs5012561 chr2:55742032 G/C cg18811423 chr2:55921094 PNPT1 -0.68 -10.56 -0.5 1.18e-22 Metabolic syndrome; CRC cis rs17818399 0.547 rs62134736 chr2:46766446 G/A cg26688816 chr2:46740690 ATP6V1E2 -0.51 -6.36 -0.33 6.81e-10 Height; CRC cis rs2980439 0.818 rs2945249 chr8:8094726 G/A cg08975724 chr8:8085496 FLJ10661 0.52 7.93 0.4 3.55e-14 Neuroticism; CRC cis rs9847710 0.733 rs2581808 chr3:53089445 C/T cg18099408 chr3:52552593 STAB1 0.41 6.14 0.32 2.4e-9 Ulcerative colitis; CRC cis rs12142240 0.698 rs13374893 chr1:46843800 A/G cg14993813 chr1:46806288 NSUN4 -0.48 -6.05 -0.32 3.98e-9 Menopause (age at onset); CRC cis rs10992471 0.729 rs6479418 chr9:95064762 G/A cg14631576 chr9:95140430 CENPP -0.39 -7.33 -0.37 1.78e-12 Visceral adipose tissue/subcutaneous adipose tissue ratio; CRC cis rs6500602 0.627 rs709632 chr16:4587811 C/G cg06139259 chr16:4526053 HMOX2;NMRAL1 -0.43 -5.82 -0.31 1.39e-8 Schizophrenia; CRC cis rs9322193 0.923 rs9322197 chr6:149943713 C/A cg07701084 chr6:150067640 NUP43 0.47 6.64 0.34 1.32e-10 Lung cancer; CRC trans rs1005277 0.579 rs2103938 chr10:38493998 T/G cg23533926 chr12:111358616 MYL2 -0.56 -8.7 -0.43 1.6e-16 Extrinsic epigenetic age acceleration; CRC cis rs9614461 0.702 rs16993867 chr22:45733199 A/G cg01808030 chr22:45809952 RIBC2;SMC1B 0.55 6.07 0.32 3.59e-9 Tonsillectomy; CRC cis rs7647973 0.626 rs1996663 chr3:49878264 C/G cg03060546 chr3:49711283 APEH -0.62 -7.68 -0.39 1.9e-13 Menarche (age at onset); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg20607318 chr19:36391512 NFKBID 0.46 6.66 0.34 1.16e-10 Response to antipsychotic treatment; CRC cis rs1008375 0.966 rs3775925 chr4:17588437 A/G cg16339924 chr4:17578868 LAP3 0.59 7.9 0.4 4.33e-14 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs72945132 0.882 rs17160777 chr11:70163723 T/C cg00319359 chr11:70116639 PPFIA1 0.67 7.46 0.38 7.95e-13 Coronary artery disease; CRC cis rs1008375 0.900 rs4698622 chr4:17589557 C/T cg16339924 chr4:17578868 LAP3 0.67 8.46 0.42 8.68e-16 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs34779708 0.931 rs11010082 chr10:35351155 A/G cg03585969 chr10:35415529 CREM 0.58 7.82 0.4 7.34e-14 Inflammatory bowel disease;Crohn's disease; CRC cis rs873946 0.648 rs35417213 chr10:134553749 A/G cg06453172 chr10:134556979 INPP5A -0.7 -8.67 -0.43 2.06e-16 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CRC cis rs3733585 0.699 rs6815001 chr4:9958662 G/C cg11266682 chr4:10021025 SLC2A9 -0.47 -9.67 -0.47 1.2e-19 Cleft plate (environmental tobacco smoke interaction); CRC cis rs4727963 0.765 rs6971635 chr7:122704188 C/T cg03640110 chr7:122635026 TAS2R16 0.36 6.56 0.34 2.09e-10 Adverse response to chemotherapy (neutropenia/leucopenia) (docetaxel); CRC cis rs9487051 0.735 rs1260596 chr6:109519847 T/C cg21918786 chr6:109611834 NA -0.35 -6.05 -0.32 3.9e-9 Reticulocyte fraction of red cells; CRC cis rs10905065 0.931 rs11255228 chr10:5837671 T/C cg11519256 chr10:5708881 ASB13 0.51 7.6 0.39 3.17e-13 Menopause (age at onset); CRC cis rs7586879 0.719 rs7565468 chr2:25130092 C/T cg22495460 chr2:25135724 ADCY3 -0.89 -15.33 -0.65 2.07e-40 Body mass index; CRC trans rs7395662 0.570 rs11039737 chr11:48450200 G/A cg21153622 chr11:89784906 NA -0.5 -8.3 -0.42 2.71e-15 HDL cholesterol; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg10501049 chr6:105630323 NA 0.39 6.16 0.32 2.09e-9 Liver disease severity in Alagille syndrome; CRC cis rs13108904 0.870 rs12499546 chr4:1255194 C/T cg23123621 chr4:1343375 KIAA1530 0.32 5.64 0.3 3.65e-8 Obesity-related traits; CRC cis rs11971779 0.680 rs4398844 chr7:139043139 G/A cg07862535 chr7:139043722 LUC7L2 0.57 7.3 0.37 2.21e-12 Diisocyanate-induced asthma; CRC cis rs4332037 0.624 rs56256289 chr7:1892529 C/T cg23422044 chr7:1970798 MAD1L1 -0.51 -6.67 -0.35 1.06e-10 Bipolar disorder; CRC cis rs10504229 0.517 rs75486476 chr8:58056079 G/T cg09858108 chr8:58055024 NA 0.5 8.09 0.41 1.15e-14 Developmental language disorder (linguistic errors); CRC cis rs9399135 0.933 rs9389262 chr6:135376409 G/T cg24558204 chr6:135376177 HBS1L 0.49 7.67 0.39 1.97e-13 Red blood cell count; CRC cis rs72945132 0.882 rs55905028 chr11:70127750 G/A cg14191688 chr11:70257035 CTTN 0.4 5.62 0.3 4.07e-8 Coronary artery disease; CRC cis rs826838 0.967 rs11183622 chr12:38792849 T/C cg13010199 chr12:38710504 ALG10B 0.46 5.98 0.31 5.88e-9 Heart rate; CRC cis rs7429990 0.965 rs796566 chr3:47938354 G/C cg11946769 chr3:48343235 NME6 0.44 5.7 0.3 2.69e-8 Educational attainment (years of education); CRC cis rs7666738 0.830 rs35752787 chr4:98935202 G/A cg17366294 chr4:99064904 C4orf37 0.43 7.32 0.37 1.95e-12 Colonoscopy-negative controls vs population controls; CRC cis rs12530845 0.887 rs78641973 chr7:135324311 C/T cg23117316 chr7:135346802 PL-5283 -0.41 -5.73 -0.3 2.27e-8 Red blood cell traits; CRC cis rs55823223 0.648 rs936394 chr17:73852008 C/A cg08125733 chr17:73851984 WBP2 1.01 13.49 0.6 2.68e-33 Psoriasis; CRC cis rs7737355 0.947 rs7724769 chr5:130954943 C/T cg06307176 chr5:131281290 NA 0.44 6.25 0.33 1.31e-9 Life satisfaction; CRC trans rs4843747 0.671 rs28465438 chr16:88103714 G/A cg26811252 chr16:29126840 RRN3P2 0.72 9.71 0.47 9.21e-20 Menopause (age at onset); CRC cis rs9560113 0.806 rs9560112 chr13:112183320 A/G cg10483660 chr13:112241077 NA 0.37 5.98 0.31 5.85e-9 Menarche (age at onset); CRC cis rs1451375 0.617 rs10271341 chr7:50591583 A/C cg14593290 chr7:50529359 DDC 0.62 8.12 0.41 9.4e-15 Malaria; CRC cis rs10971721 0.822 rs72727329 chr9:33921664 C/A cg13495928 chr9:33750294 PRSS3 0.56 5.97 0.31 6.15e-9 Body mass index; CRC cis rs9816226 1.000 rs55835921 chr3:185831474 T/C cg00760338 chr3:185826511 ETV5 -0.67 -7.23 -0.37 3.31e-12 Obesity;Body mass index; CRC cis rs12541335 0.639 rs35068739 chr8:22201719 T/C cg14487702 chr8:22132665 PIWIL2 0.39 5.89 0.31 9.46e-9 Hypertriglyceridemia; CRC cis rs2658782 0.951 rs72972364 chr11:93122128 C/T cg15737290 chr11:93063684 CCDC67 -0.53 -7.19 -0.37 4.31e-12 Pulmonary function decline; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg15766557 chr19:46234224 FBXO46 0.43 6.24 0.33 1.34e-9 Intelligence (multi-trait analysis); CRC cis rs875971 0.793 rs460678 chr7:65527200 C/G cg18876405 chr7:65276391 NA 0.52 8.82 0.44 6.64e-17 Aortic root size; CRC cis rs1005277 0.579 rs1780115 chr10:38524773 C/T cg25427524 chr10:38739819 LOC399744 -0.79 -14.49 -0.62 3.78e-37 Extrinsic epigenetic age acceleration; CRC cis rs1656402 0.954 rs11676436 chr2:233453063 A/G cg03852847 chr2:233439513 NA -0.39 -6.64 -0.34 1.27e-10 Non-small cell lung cancer (survival); CRC cis rs909002 0.772 rs7525618 chr1:32073766 C/T cg13919466 chr1:32135498 COL16A1 -0.31 -5.79 -0.3 1.67e-8 Intelligence (multi-trait analysis); CRC cis rs832540 0.931 rs702679 chr5:56221328 A/G cg24531977 chr5:56204891 C5orf35 -0.48 -7.49 -0.38 6.23e-13 Coronary artery disease; CRC cis rs2832191 0.716 rs2297252 chr21:30377104 G/A cg24692254 chr21:30365293 RNF160 0.85 15.96 0.66 7.24e-43 Dental caries; CRC cis rs2227564 0.678 rs2242256 chr10:75597546 C/G cg00564723 chr10:75632066 CAMK2G 0.37 8.8 0.44 8.01e-17 Crohn's disease;Inflammatory bowel disease; CRC cis rs9372498 0.536 rs9489394 chr6:118758234 T/C cg22561889 chr6:118971681 C6orf204 0.53 6.87 0.35 3.16e-11 Diastolic blood pressure; CRC cis rs4481887 0.927 rs4551626 chr1:248489128 G/T cg00666640 chr1:248458726 OR2T12 0.49 8.29 0.42 3.01e-15 Common traits (Other); CRC cis rs2153535 0.580 rs1932279 chr6:8473653 T/C cg21535247 chr6:8435926 SLC35B3 0.49 7.4 0.38 1.14e-12 Motion sickness; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg05013783 chr12:56652058 ANKRD52 0.49 7.01 0.36 1.37e-11 Response to antipsychotic treatment; CRC cis rs34526934 0.608 rs7606110 chr2:177028551 T/C cg26754761 chr2:177040938 NA -0.45 -6.68 -0.35 1.01e-10 Obstructive sleep apnea trait (apnea hypopnea index); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg24770856 chr10:127512017 BCCIP;UROS 0.45 6.48 0.34 3.27e-10 Response to antipsychotic treatment; CRC cis rs977987 0.806 rs1109342 chr16:75445675 A/G cg03315344 chr16:75512273 CHST6 -0.54 -8.93 -0.44 3.11e-17 Dupuytren's disease; CRC cis rs910316 1.000 rs12879542 chr14:75507525 C/T cg11812906 chr14:75593930 NEK9 0.63 10.0 0.48 9.8e-21 Height; CRC trans rs7647973 0.667 rs9869256 chr3:49624095 T/G cg21659725 chr3:3221576 CRBN -0.64 -6.07 -0.32 3.52e-9 Menarche (age at onset); CRC cis rs7937682 0.632 rs11214028 chr11:111761149 T/C cg19812747 chr11:111475976 SIK2 0.44 6.34 0.33 7.7e-10 Primary sclerosing cholangitis; CRC trans rs1005277 0.579 rs2504148 chr10:38400788 A/G cg23533926 chr12:111358616 MYL2 -0.51 -7.68 -0.39 1.84e-13 Extrinsic epigenetic age acceleration; CRC cis rs2066819 0.892 rs77415512 chr12:56627300 A/G cg26714650 chr12:56694279 CS -1.43 -11.59 -0.54 2.88e-26 Psoriasis vulgaris; CRC cis rs11971779 0.838 rs11764161 chr7:139115198 T/C cg07862535 chr7:139043722 LUC7L2 0.88 10.95 0.52 5.48e-24 Diisocyanate-induced asthma; CRC cis rs67478160 0.643 rs6576005 chr14:104292369 C/T cg01849466 chr14:104193079 ZFYVE21 -0.54 -9.99 -0.48 1.08e-20 Schizophrenia; CRC cis rs2576037 0.526 rs4258717 chr18:44456954 T/C cg19077165 chr18:44547161 KATNAL2 -0.6 -10.1 -0.49 4.6e-21 Personality dimensions; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg17539315 chr12:50794919 LARP4 0.55 7.14 0.37 6.1e-12 Thyroid stimulating hormone; CRC cis rs2404602 0.583 rs2176623 chr15:76568579 C/T cg22467129 chr15:76604101 ETFA -0.5 -8.78 -0.44 9.1e-17 Blood metabolite levels; CRC trans rs11764590 0.694 rs6461115 chr7:2103668 A/G cg11693508 chr17:37793320 STARD3 0.5 6.61 0.34 1.52e-10 Neuroticism; CRC cis rs17092148 0.887 rs6059936 chr20:33184249 C/T cg08999081 chr20:33150536 PIGU 0.49 6.3 0.33 9.31e-10 Neuroticism; CRC cis rs28386778 0.897 rs4968598 chr17:61835579 T/C cg06601766 chr17:61851465 DDX42;CCDC47 0.44 5.97 0.31 6.14e-9 Prudent dietary pattern; CRC cis rs2836974 0.666 rs11910705 chr21:40685604 C/T cg11890956 chr21:40555474 PSMG1 -0.85 -13.6 -0.6 9.92e-34 Cognitive function; CRC cis rs12586317 0.582 rs731906 chr14:35604543 C/T cg05294307 chr14:35346193 BAZ1A -0.67 -7.08 -0.36 8.63e-12 Psoriasis; CRC cis rs2032447 0.772 rs199754 chr6:25992309 A/G cg03517284 chr6:25882590 NA -0.58 -7.84 -0.4 6.35e-14 Intelligence (multi-trait analysis); CRC cis rs10540 1.000 rs67912009 chr11:495057 G/T cg21784768 chr11:537496 LRRC56 -0.58 -5.87 -0.31 1.08e-8 Body mass index; CRC cis rs4819052 0.851 rs13048789 chr21:46660714 A/G cg11663144 chr21:46675770 NA -0.83 -14.12 -0.61 9.88e-36 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs1953600 0.668 rs3122586 chr10:81950326 C/T cg11900509 chr10:81946545 ANXA11 0.38 6.17 0.32 2.04e-9 Sarcoidosis; CRC cis rs747650 0.892 rs7937101 chr11:47226488 A/G cg19486271 chr11:47235900 DDB2 -0.52 -8.11 -0.41 1e-14 Acne (severe); CRC cis rs2243480 1.000 rs316325 chr7:65609518 G/A cg25985355 chr7:65971099 NA -0.52 -6.1 -0.32 3.05e-9 Diabetic kidney disease; CRC trans rs6545883 0.931 rs7557230 chr2:61736652 A/T cg11704114 chr12:21509398 SLCO1A2 -0.32 -6.0 -0.31 5.08e-9 Tuberculosis; CRC cis rs9611519 1.000 rs6002271 chr22:41566595 C/T cg03806693 chr22:41940476 POLR3H -0.55 -6.92 -0.36 2.38e-11 Neuroticism; CRC cis rs4243830 0.737 rs11581831 chr1:6609958 C/T cg22792644 chr1:6614718 TAS1R1;NOL9 -0.81 -9.88 -0.48 2.55e-20 Body mass index; CRC trans rs2303319 0.504 rs62189051 chr2:162622318 G/A cg22922770 chr7:98923339 ARPC1A -0.67 -5.99 -0.31 5.55e-9 Cognitive function; CRC cis rs3820068 0.603 rs6696286 chr1:15968770 C/T cg27534772 chr1:16042836 PLEKHM2 0.53 10.3 0.49 9.51e-22 Systolic blood pressure; CRC cis rs909002 0.800 rs1056526 chr1:32084904 C/T cg13919466 chr1:32135498 COL16A1 -0.3 -5.73 -0.3 2.3e-8 Intelligence (multi-trait analysis); CRC cis rs7625357 1.000 rs7625357 chr3:169347832 C/T cg04414509 chr3:169351419 MECOM 0.59 8.95 0.44 2.73e-17 Childhood and early adolescence aggressive behavior; CRC trans rs1814175 0.817 rs7481230 chr11:49772235 G/A cg11707556 chr5:10655725 ANKRD33B -0.42 -7.9 -0.4 4.18e-14 Height; CRC cis rs4713118 0.513 rs200971 chr6:27858904 C/T cg15845792 chr6:28175446 NA 0.76 10.78 0.51 2.11e-23 Parkinson's disease; CRC cis rs2953145 0.617 rs7557192 chr2:241541274 T/C cg07929629 chr2:241523174 NA 0.67 9.67 0.47 1.23e-19 Bipolar disorder; CRC cis rs6951245 1.000 rs111899361 chr7:1112348 C/T cg24642844 chr7:1081250 C7orf50 -0.78 -9.34 -0.46 1.47e-18 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs1552244 1.000 rs2272125 chr3:10138069 A/C cg08888203 chr3:10149979 C3orf24 0.67 9.7 0.47 9.79e-20 Alzheimer's disease; CRC cis rs597539 0.652 rs507520 chr11:68666054 C/T cg21963583 chr11:68658836 MRPL21 0.64 11.61 0.54 2.3e-26 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs231513 0.911 rs124720 chr17:41960141 A/G cg26893861 chr17:41843967 DUSP3 -0.72 -6.5 -0.34 3.05e-10 Cognitive function; CRC trans rs208520 0.690 rs12202913 chr6:66734198 C/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 1.05 14.74 0.63 4.18e-38 Exhaled nitric oxide output; CRC cis rs11123610 0.520 rs60644898 chr2:3718646 G/A cg19052272 chr2:3704530 ALLC -0.62 -7.69 -0.39 1.68e-13 Response to inhaled corticosteroid treatment in asthma (change in FEV1); CRC cis rs7258465 1.000 rs8107367 chr19:18564705 A/G cg10790698 chr19:18539756 SSBP4 -0.44 -8.38 -0.42 1.59e-15 Breast cancer; CRC cis rs10782582 0.593 rs11164042 chr1:76178440 G/A cg10523679 chr1:76189770 ACADM -0.39 -5.61 -0.3 4.36e-8 Daytime sleep phenotypes; CRC cis rs3862260 0.509 rs10923879 chr1:120163831 A/G cg11530693 chr1:120165357 ZNF697 0.61 9.58 0.47 2.56e-19 Systemic lupus erythematosus; CRC trans rs12699921 0.632 rs2691615 chr7:17887180 C/G cg02066331 chr6:17282778 RBM24 -0.35 -6.05 -0.32 3.99e-9 Fibrinogen levels; CRC cis rs11583043 0.918 rs11581062 chr1:101407519 C/T cg16556008 chr1:101360663 SLC30A7;EXTL2 -0.57 -8.22 -0.41 4.85e-15 Ulcerative colitis;Inflammatory bowel disease; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg10297971 chr15:93426637 NA 0.38 6.01 0.31 4.79e-9 Liver disease severity in Alagille syndrome; CRC trans rs875971 0.660 rs2191268 chr7:66110224 C/T cg01500633 chr6:86387148 SNORD50A;SNHG5 -0.38 -5.97 -0.31 6.24e-9 Aortic root size; CRC cis rs7020830 0.898 rs13290794 chr9:37183628 C/T cg14294708 chr9:37120828 ZCCHC7 1.14 23.24 0.79 2.2e-71 Schizophrenia; CRC cis rs4478858 0.735 rs4949389 chr1:31824023 A/G cg00250761 chr1:31883323 NA 0.41 7.62 0.39 2.81e-13 Alcohol dependence; CRC cis rs7412746 0.658 rs11204723 chr1:150731618 T/C cg10589385 chr1:150898437 SETDB1 0.31 6.34 0.33 7.79e-10 Melanoma; CRC cis rs7927592 0.913 rs55883802 chr11:68278829 G/A cg16797656 chr11:68205561 LRP5 0.37 5.75 0.3 2.05e-8 Total body bone mineral density; CRC cis rs7399018 0.739 rs6580811 chr12:51612501 T/C cg12163867 chr12:51592794 POU6F1 -0.54 -7.88 -0.4 4.89e-14 Cisplatin-induced ototoxicity; CRC cis rs2880765 0.743 rs8028240 chr15:86013248 A/G cg17133734 chr15:86042851 AKAP13 0.39 6.19 0.32 1.82e-9 Coronary artery disease; CRC cis rs12594515 1.000 rs8038058 chr15:45990272 C/T cg01629716 chr15:45996671 NA 0.4 8.35 0.42 1.89e-15 Waist circumference;Weight; CRC cis rs9291683 0.588 rs2240721 chr4:10020564 G/A cg00071950 chr4:10020882 SLC2A9 0.68 13.34 0.59 9.15e-33 Bone mineral density; CRC cis rs11190604 1.000 rs2298075 chr10:102247408 C/A cg16342193 chr10:102329863 NA -0.37 -6.01 -0.31 5.02e-9 Palmitoleic acid (16:1n-7) levels; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg04911280 chr6:44281184 AARS2 0.37 6.09 0.32 3.08e-9 Liver disease severity in Alagille syndrome; CRC cis rs77633900 0.614 rs2629025 chr15:76943363 G/C cg21673338 chr15:77095150 SCAPER -0.74 -7.43 -0.38 9.68e-13 Non-glioblastoma glioma;Glioma; CRC cis rs67311347 1.000 rs12630072 chr3:40517190 T/G cg09455208 chr3:40491958 NA 0.51 9.78 0.47 5.53e-20 Renal cell carcinoma; CRC cis rs2404602 0.552 rs4886823 chr15:76965402 A/G cg03037974 chr15:76606532 NA -0.43 -5.99 -0.31 5.44e-9 Blood metabolite levels; CRC cis rs2153535 0.580 rs9379222 chr6:8514788 T/C cg07606381 chr6:8435919 SLC35B3 0.65 10.53 0.5 1.58e-22 Motion sickness; CRC cis rs11250464 0.755 rs11250468 chr10:1410060 A/G cg26394196 chr10:1453818 ADARB2 -0.33 -5.83 -0.31 1.34e-8 Radiation response; CRC cis rs6741892 0.536 rs11688977 chr2:38896631 C/T cg00359181 chr2:38893519 GALM -0.55 -5.89 -0.31 9.3e-9 5-HTT brain serotonin transporter levels; CRC cis rs6752107 1.000 rs34123137 chr2:234167881 T/A cg07618928 chr2:234183455 ATG16L1;SCARNA5 0.64 11.03 0.52 2.69e-24 Crohn's disease;Inflammatory bowel disease; CRC cis rs3126085 0.515 rs11204998 chr1:152365655 A/C cg09127314 chr1:152161683 NA -0.44 -5.87 -0.31 1.06e-8 Atopic dermatitis; CRC cis rs6951245 1.000 rs113575110 chr7:1084394 G/A cg07217954 chr7:1067459 C7orf50 0.55 5.61 0.3 4.23e-8 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs9322193 0.962 rs17673294 chr6:150134993 G/A cg00933542 chr6:150070202 PCMT1 0.28 5.65 0.3 3.4e-8 Lung cancer; CRC cis rs13108904 0.875 rs10024013 chr4:1280792 C/T cg20092199 chr4:1342459 KIAA1530 -0.38 -6.8 -0.35 4.94e-11 Obesity-related traits; CRC cis rs13191362 1.000 rs34066731 chr6:163011047 A/G cg06582575 chr6:163149167 PACRG;PARK2 0.75 10.24 0.49 1.58e-21 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs4665809 1.000 rs2384323 chr2:26306473 C/T cg04944784 chr2:26401820 FAM59B -0.6 -7.7 -0.39 1.62e-13 Gut microbiome composition (summer); CRC cis rs3733585 0.699 rs13328050 chr4:9951120 G/T cg11266682 chr4:10021025 SLC2A9 -0.46 -9.35 -0.46 1.35e-18 Cleft plate (environmental tobacco smoke interaction); CRC cis rs12216125 0.549 rs9358905 chr6:26077839 T/A cg16482183 chr6:26056742 HIST1H1C 0.51 7.33 0.37 1.77e-12 Iron status biomarkers; CRC cis rs1971762 0.563 rs7975862 chr12:54078427 A/C cg06632207 chr12:54070931 ATP5G2 -0.41 -7.26 -0.37 2.89e-12 Height; CRC cis rs769267 0.930 rs1865034 chr19:19605763 C/T cg03709012 chr19:19516395 GATAD2A 0.73 11.32 0.53 2.66e-25 Tonsillectomy; CRC cis rs12995491 0.698 rs34352413 chr2:88498754 T/G cg18490616 chr2:88469792 THNSL2 -0.44 -6.39 -0.33 5.61e-10 Response to metformin (IC50); CRC cis rs847577 0.587 rs34307903 chr7:97728449 C/A cg21770322 chr7:97807741 LMTK2 0.85 19.36 0.73 2.8e-56 Breast cancer; CRC cis rs2971970 0.539 rs2971972 chr7:133644200 A/G cg03336402 chr7:133662267 EXOC4 -0.66 -10.33 -0.5 7.31e-22 Intelligence (multi-trait analysis); CRC cis rs7814319 0.966 rs6993518 chr8:97256341 T/A cg20787634 chr8:97240163 UQCRB -0.56 -9.86 -0.48 2.94e-20 Lung function (FVC); CRC cis rs4803468 0.967 rs4803462 chr19:41908936 T/A cg09537434 chr19:41945824 ATP5SL -0.98 -18.95 -0.72 1.19e-54 Height; CRC cis rs6543140 0.964 rs10193485 chr2:103089573 T/C cg04239558 chr2:103089729 SLC9A4 0.38 6.64 0.34 1.29e-10 Blood protein levels; CRC cis rs896854 0.608 rs7004862 chr8:95876963 T/G cg23172400 chr8:95962367 TP53INP1 -0.43 -6.89 -0.36 2.83e-11 Type 2 diabetes; CRC cis rs597539 0.652 rs579136 chr11:68637476 C/G cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.89 15.85 0.66 1.89e-42 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs9811920 0.770 rs4928237 chr3:99731330 A/T cg07805332 chr3:99536008 MIR548G;C3orf26 0.39 5.95 0.31 6.72e-9 Axial length; CRC trans rs62295889 0.602 rs62293667 chr4:12539018 T/C cg03490839 chr16:73082051 ZFHX3 0.59 6.38 0.33 5.96e-10 Obesity-related traits; CRC cis rs11098499 0.863 rs10019674 chr4:120443489 C/T cg24375607 chr4:120327624 NA -0.49 -7.22 -0.37 3.74e-12 Corneal astigmatism; CRC cis rs9747201 0.925 rs7209621 chr17:80057099 C/T cg09264619 chr17:80180166 NA 0.47 6.51 0.34 2.73e-10 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs4478858 0.735 rs11576621 chr1:31795460 A/G cg00250761 chr1:31883323 NA -0.44 -8.52 -0.42 6.03e-16 Alcohol dependence; CRC trans rs7824557 0.583 rs2736306 chr8:11239762 A/T cg06636001 chr8:8085503 FLJ10661 0.56 8.19 0.41 5.93e-15 Retinal vascular caliber; CRC cis rs694739 0.930 rs574087 chr11:64102948 A/G cg02228329 chr11:64053129 BAD;GPR137 0.61 9.07 0.45 1.13e-17 Alopecia areata;Crohn's disease;Psoriasis vulgaris; CRC cis rs9527 0.614 rs11191589 chr10:104930382 T/C cg15744005 chr10:104629667 AS3MT -0.31 -6.18 -0.32 1.91e-9 Arsenic metabolism; CRC trans rs7824557 0.547 rs2409745 chr8:11076635 G/T cg16141378 chr3:129829833 LOC729375 -0.42 -6.11 -0.32 2.78e-9 Retinal vascular caliber; CRC cis rs7208859 0.623 rs11650271 chr17:29213943 C/T cg01831904 chr17:28903510 LRRC37B2 -0.54 -5.65 -0.3 3.39e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs12144094 0.882 rs1441011 chr1:120245374 T/C cg20995928 chr1:120229863 NA 0.46 6.61 0.34 1.56e-10 Height; CRC cis rs6951245 1.000 rs76833820 chr7:1070278 A/T cg04025307 chr7:1156635 C7orf50 0.63 6.63 0.34 1.41e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs1003719 0.788 rs2251161 chr21:38467857 C/G cg10648535 chr21:38446584 PIGP;TTC3 0.52 7.38 0.38 1.3e-12 Eye color traits; CRC cis rs12024301 0.557 rs10157789 chr1:183654973 C/A cg11505048 chr1:183622726 RGL1;APOBEC4 0.71 6.24 0.33 1.33e-9 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs798554 0.797 rs798486 chr7:2803037 A/G cg13628971 chr7:2884303 GNA12 0.54 7.29 0.37 2.36e-12 Height; CRC cis rs11190604 0.945 rs2495746 chr10:102328270 T/C cg07080220 chr10:102295463 HIF1AN 0.45 5.71 0.3 2.52e-8 Palmitoleic acid (16:1n-7) levels; CRC trans rs6600671 1.000 rs1856572 chr1:121169579 A/C cg09829573 chr1:144692074 NBPF9 -0.4 -6.07 -0.32 3.49e-9 Hip geometry; CRC trans rs7615952 0.673 rs9289270 chr3:125636979 A/T cg07211511 chr3:129823064 LOC729375 -1.1 -12.97 -0.58 2.41e-31 Blood pressure (smoking interaction); CRC cis rs2032447 0.772 rs199754 chr6:25992309 A/G cg12310025 chr6:25882481 NA -0.59 -8.22 -0.41 4.67e-15 Intelligence (multi-trait analysis); CRC cis rs10504229 0.683 rs6999351 chr8:58127227 C/T cg02290350 chr8:58132656 NA -0.58 -8.16 -0.41 7.29e-15 Developmental language disorder (linguistic errors); CRC cis rs11758351 0.587 rs2050950 chr6:26234883 A/G cg22723502 chr6:26240528 HIST1H4F -0.36 -5.92 -0.31 8.02e-9 Gout;Renal underexcretion gout; CRC cis rs11585357 0.947 rs6666990 chr1:17611520 G/A cg08277548 chr1:17600880 PADI3 0.7 9.71 0.47 9.08e-20 Hair shape; CRC cis rs9368481 0.645 rs10456350 chr6:26975581 A/C cg18867708 chr6:26865862 GUSBL1 0.42 6.11 0.32 2.83e-9 Autism spectrum disorder or schizophrenia; CRC cis rs1707322 0.963 rs34907901 chr1:46405214 T/G cg06784218 chr1:46089804 CCDC17 0.49 8.35 0.42 1.98e-15 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs6594499 0.872 rs10038058 chr5:110443281 A/G cg04022379 chr5:110408740 TSLP 0.44 6.66 0.34 1.13e-10 Allergic disease (asthma, hay fever or eczema); CRC cis rs9910055 0.530 rs2269908 chr17:42294198 G/C cg19774624 chr17:42201019 HDAC5 -0.39 -5.83 -0.31 1.32e-8 Total body bone mineral density; CRC cis rs10870270 1.000 rs4880246 chr10:133764064 C/T cg08754478 chr10:133766260 PPP2R2D -0.66 -9.33 -0.46 1.67e-18 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; CRC cis rs28386778 0.897 rs2156903 chr17:61937179 G/A cg23090583 chr17:61904693 PSMC5;FTSJ3 1.03 20.09 0.74 3.8e-59 Prudent dietary pattern; CRC cis rs7666738 0.570 rs10032272 chr4:99095601 T/C cg05340658 chr4:99064831 C4orf37 0.49 7.06 0.36 9.8e-12 Colonoscopy-negative controls vs population controls; CRC cis rs863345 0.604 rs1342945 chr1:158512912 C/A cg12129480 chr1:158549410 OR10X1 -0.3 -6.42 -0.33 4.84e-10 Pneumococcal bacteremia; CRC cis rs7527798 0.592 rs12119104 chr1:207861207 A/G cg09232269 chr1:207846808 CR1L -0.48 -7.85 -0.4 5.98e-14 Erythrocyte sedimentation rate; CRC cis rs10540 1.000 rs61876334 chr11:487201 T/C cg03352830 chr11:487213 PTDSS2 0.65 7.33 0.37 1.83e-12 Body mass index; CRC cis rs9354352 0.967 rs6455062 chr6:66694131 T/A cg07460842 chr6:66804631 NA 0.62 9.08 0.45 1.03e-17 Initial pursuit acceleration in psychotic disorders; CRC cis rs35110281 0.811 rs9980185 chr21:45057905 A/G cg01579765 chr21:45077557 HSF2BP -0.34 -6.49 -0.34 3.07e-10 Mean corpuscular volume; CRC cis rs7258465 1.000 rs4808801 chr19:18571141 A/G cg10790698 chr19:18539756 SSBP4 -0.43 -8.13 -0.41 8.79e-15 Breast cancer; CRC cis rs9796 0.558 rs6492993 chr15:41526104 G/A cg18705301 chr15:41695430 NDUFAF1 -0.4 -6.86 -0.35 3.43e-11 Menopause (age at onset); CRC cis rs1511802 0.666 rs28698123 chr4:187123189 C/T cg24794857 chr4:187113578 CYP4V2 0.39 5.69 0.3 2.86e-8 Blood protein levels; CRC cis rs10736390 1.000 rs11206402 chr1:55104317 G/C cg01517571 chr1:55089959 ACOT11;FAM151A -0.77 -12.69 -0.57 2.61e-30 Survival in pancreatic cancer; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg03885414 chr19:54240196 NA 0.29 6.12 0.32 2.69e-9 Liver disease severity in Alagille syndrome; CRC cis rs10464366 0.544 rs4540324 chr7:39185299 G/C cg15212455 chr7:39170539 POU6F2 0.5 6.56 0.34 2.03e-10 IgG glycosylation; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg02970425 chr20:48552805 RNF114 0.44 6.4 0.33 5.47e-10 Response to antipsychotic treatment; CRC cis rs62103177 0.810 rs62096746 chr18:77619556 T/A cg12964065 chr18:77638022 KCNG2 0.62 6.64 0.34 1.3100000000000001e-10 Opioid sensitivity; CRC cis rs561341 0.941 rs2428341 chr17:30317295 C/T cg23018236 chr17:30244563 NA -0.47 -6.62 -0.34 1.5e-10 Hip circumference adjusted for BMI; CRC cis rs7615952 0.512 rs2979336 chr3:125357470 G/A cg11143507 chr3:125485238 NA -0.57 -7.35 -0.38 1.55e-12 Blood pressure (smoking interaction); CRC trans rs2228479 0.867 rs11642451 chr16:89958127 T/C cg24644049 chr4:85504048 CDS1 0.84 7.48 0.38 6.98e-13 Skin colour saturation; CRC cis rs2115630 0.645 rs3825877 chr15:85174631 G/A cg09876464 chr15:85330779 ZNF592 0.39 6.48 0.34 3.34e-10 P wave terminal force; CRC cis rs243505 0.528 rs740951 chr7:148470160 C/A cg09806900 chr7:148480153 CUL1 0.57 7.99 0.4 2.26e-14 Inflammatory bowel disease;Crohn's disease; CRC trans rs7647973 0.626 rs1586827 chr3:49671224 T/C cg21665057 chr3:196295764 WDR53;FBXO45 -0.67 -7.48 -0.38 6.83e-13 Menarche (age at onset); CRC cis rs75920871 0.528 rs682048 chr11:116828320 T/G cg20608306 chr11:116969690 SIK3 -0.34 -6.41 -0.33 5.09e-10 Subjective well-being; CRC trans rs4942242 0.659 rs1105586 chr13:44232633 C/T cg26741380 chr15:41871084 TYRO3 0.44 6.93 0.36 2.24e-11 Response to tocilizumab in rheumatoid arthritis; CRC cis rs875971 0.862 rs949930 chr7:65766822 C/G cg11764359 chr7:65958608 NA -0.6 -9.4 -0.46 9.45e-19 Aortic root size; CRC cis rs6912958 0.559 rs451465 chr6:88043372 C/T cg12350822 chr6:88032061 C6orf162;GJB7 -0.47 -9.7 -0.47 9.86e-20 Monocyte percentage of white cells; CRC cis rs911119 0.913 rs6048929 chr20:23588855 T/C cg16589663 chr20:23618590 CST3 0.45 6.44 0.33 4.34e-10 Chronic kidney disease; CRC cis rs270601 0.633 rs4535443 chr5:131572561 A/G cg22638593 chr5:131593259 PDLIM4 0.52 9.14 0.45 6.39e-18 Acylcarnitine levels; CRC cis rs7619833 0.620 rs2370946 chr3:27260283 A/G cg02860705 chr3:27208620 NA -0.38 -6.04 -0.32 4.06e-9 Breast cancer; CRC cis rs7811142 0.943 rs111493473 chr7:100049742 A/G cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.16 17.99 0.7 7.42e-51 Platelet count; CRC cis rs4434138 0.664 rs62255364 chr3:52701502 C/T cg08222913 chr3:52553049 STAB1 -0.35 -6.4 -0.33 5.43e-10 Intelligence (multi-trait analysis); CRC cis rs7772486 0.790 rs9403755 chr6:146231470 C/A cg13319975 chr6:146136371 FBXO30 0.41 6.15 0.32 2.25e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs1008375 0.932 rs4698629 chr4:17608884 C/G cg16339924 chr4:17578868 LAP3 0.5 6.35 0.33 7e-10 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs2976388 0.556 rs4736323 chr8:143830359 C/T cg15511327 chr8:143859410 LYNX1 -0.41 -6.32 -0.33 8.38e-10 Urinary tract infection frequency; CRC cis rs7618915 0.547 rs35211965 chr3:52685305 C/G cg15147215 chr3:52552868 STAB1 -0.62 -10.31 -0.49 8.76e-22 Bipolar disorder; CRC cis rs7833986 0.501 rs72653981 chr8:57027814 G/A cg23139584 chr8:56987506 RPS20;SNORD54 0.91 12.31 0.56 6.9e-29 Height; CRC cis rs1129187 0.755 rs9471988 chr6:42944773 T/C cg21280719 chr6:42927975 GNMT -0.45 -9.97 -0.48 1.25e-20 Alzheimer's disease in APOE e4+ carriers; CRC cis rs6701037 0.555 rs10912899 chr1:175120715 C/T cg00321850 chr1:175162397 KIAA0040 0.38 6.5 0.34 2.98e-10 Alcohol dependence; CRC cis rs5750830 0.649 rs5750814 chr22:39797987 T/C cg25956985 chr22:39795188 MAP3K7IP1 -0.43 -6.44 -0.33 4.22e-10 Intelligence (multi-trait analysis); CRC cis rs9291683 0.510 rs4318649 chr4:10016815 T/C cg00071950 chr4:10020882 SLC2A9 0.62 11.19 0.53 7.45e-25 Bone mineral density; CRC cis rs708547 0.874 rs1718837 chr4:57871203 A/G cg25525207 chr4:57843836 C4orf14;POLR2B -0.48 -6.23 -0.32 1.4e-9 Response to bleomycin (chromatid breaks); CRC cis rs6089584 0.927 rs2296081 chr20:60572663 G/T cg23463467 chr20:60627584 TAF4 0.3 5.62 0.3 4.12e-8 Body mass index; CRC cis rs72781680 0.581 rs116520786 chr2:24272645 C/T cg20701182 chr2:24300061 SF3B14 0.63 6.99 0.36 1.58e-11 Lymphocyte counts; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg01140101 chr1:202113040 ARL8A 0.45 6.84 0.35 3.81e-11 Intelligence (multi-trait analysis); CRC cis rs8060686 0.641 rs79719939 chr16:68240216 A/G cg08314208 chr16:67682810 RLTPR -0.6 -6.42 -0.33 4.82e-10 HDL cholesterol;Metabolic syndrome; CRC cis rs1519814 1.000 rs7826920 chr8:121121010 T/C cg22335954 chr8:121166405 COL14A1 -0.49 -6.1 -0.32 3.06e-9 Breast cancer; CRC cis rs6951245 1.000 rs75488469 chr7:1102122 A/G cg22907277 chr7:1156413 C7orf50 0.72 7.66 0.39 2.06e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC trans rs1784692 1.000 rs1784692 chr11:113949232 A/G cg07057617 chr6:170405951 NA 0.52 6.03 0.32 4.37e-9 Polycystic ovary syndrome; CRC cis rs12476592 0.602 rs262514 chr2:63890920 C/T cg10828910 chr2:63850056 LOC388955 0.51 6.44 0.33 4.22e-10 Childhood ear infection; CRC trans rs2303319 0.504 rs56965753 chr2:162597251 A/G cg22627826 chr19:1240265 ATP5D -0.72 -6.24 -0.33 1.32e-9 Cognitive function; CRC trans rs6550704 0.687 rs9865314 chr3:22634337 A/G cg24607948 chr9:100459097 XPA -0.41 -6.16 -0.32 2.18e-9 Daytime sleep phenotypes; CRC cis rs11098499 0.821 rs3775852 chr4:120454556 A/G cg24375607 chr4:120327624 NA 0.47 7.05 0.36 1.06e-11 Corneal astigmatism; CRC cis rs875971 0.660 rs79009421 chr7:66068509 G/C cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.43 -6.42 -0.33 4.8e-10 Aortic root size; CRC cis rs3858526 0.959 rs4559671 chr11:5923419 C/T cg26762873 chr11:5879799 OR52E8 -0.39 -5.72 -0.3 2.35e-8 DNA methylation (variation); CRC cis rs9807989 0.507 rs6726985 chr2:103048580 G/A cg03938978 chr2:103052716 IL18RAP 0.59 10.09 0.49 4.8e-21 Asthma; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg21041329 chr8:56686126 TMEM68;TGS1 0.39 6.61 0.34 1.57e-10 Liver disease severity in Alagille syndrome; CRC cis rs4285028 0.747 rs1127412 chr3:121414061 C/T cg20356878 chr3:121714668 ILDR1 -0.42 -6.08 -0.32 3.25e-9 Multiple sclerosis; CRC cis rs802075 1.000 rs4711935 chr6:49647822 C/T cg20364632 chr6:49636226 NA -0.36 -5.71 -0.3 2.53e-8 Bone mineral density (hip) and age at menarche; CRC cis rs7224737 1.000 rs11869069 chr17:40287101 C/G cg20291162 chr17:40259547 DHX58 -0.56 -8.24 -0.41 4.27e-15 Fibrinogen levels; CRC cis rs6951245 1.000 rs78158942 chr7:1090440 G/T cg22907277 chr7:1156413 C7orf50 0.7 7.14 0.37 6.14e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs56235845 0.694 rs6860069 chr5:176755841 C/T cg05207973 chr5:176823642 SLC34A1 0.35 5.88 0.31 1.03e-8 Hemoglobin concentration;Hematocrit; CRC cis rs10197940 0.624 rs10497081 chr2:152353395 T/G cg19508488 chr2:152266495 RIF1 0.6 8.27 0.41 3.47e-15 Lung cancer; CRC cis rs4629180 1.000 rs4851457 chr2:102091220 C/T cg12464048 chr2:102091129 RFX8 0.44 6.18 0.32 1.86e-9 Chronic rhinosinusitis with nasal polyps; CRC cis rs17666538 0.585 rs336444 chr8:633123 C/G cg10396713 chr8:602097 NA -0.47 -5.66 -0.3 3.34e-8 IgG glycosylation; CRC cis rs7909074 1.000 rs7079573 chr10:45400406 G/A cg04218760 chr10:45406644 TMEM72 -0.35 -9.74 -0.47 7.52e-20 Mean corpuscular volume; CRC cis rs921968 0.565 rs35189512 chr2:219628759 T/C cg02176678 chr2:219576539 TTLL4 -0.43 -6.85 -0.35 3.58e-11 Mean corpuscular hemoglobin concentration; CRC cis rs12760731 0.582 rs35304375 chr1:178539180 A/G cg00404053 chr1:178313656 RASAL2 0.63 7.09 0.36 8.37e-12 Obesity-related traits; CRC trans rs728616 0.681 rs17100316 chr10:81913337 A/G cg18543242 chr14:23290393 SLC7A7 0.43 5.98 0.31 5.79e-9 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs826838 1.000 rs4768328 chr12:39129315 C/T cg13010199 chr12:38710504 ALG10B -0.41 -5.84 -0.31 1.27e-8 Heart rate; CRC cis rs6963495 0.719 rs73190172 chr7:105161210 T/C cg13798780 chr7:105162888 PUS7 0.68 8.08 0.41 1.27e-14 Bipolar disorder (body mass index interaction); CRC cis rs7044106 0.762 rs3903886 chr9:123383646 A/G cg14255062 chr9:123606675 PSMD5;LOC253039 -0.46 -7.18 -0.37 4.6e-12 Hip circumference adjusted for BMI; CRC trans rs11764590 0.694 rs2056477 chr7:2079744 G/C cg11693508 chr17:37793320 STARD3 0.53 7.03 0.36 1.22e-11 Neuroticism; CRC cis rs11764590 0.585 rs11772463 chr7:2078132 A/C cg02825527 chr7:2087843 MAD1L1 -0.48 -5.65 -0.3 3.41e-8 Neuroticism; CRC cis rs9814567 1.000 rs2370578 chr3:134199612 G/A cg06109529 chr3:134205091 CEP63;ANAPC13 -0.83 -12.32 -0.56 6.35e-29 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs6499255 1.000 rs11075734 chr16:69801397 G/T cg04110750 chr16:69646130 NFAT5 -0.5 -6.87 -0.35 3.16e-11 IgE levels; CRC cis rs12701220 0.542 rs6957866 chr7:1111674 G/A cg02733842 chr7:1102375 C7orf50 -0.91 -11.53 -0.54 4.59e-26 Bronchopulmonary dysplasia; CRC cis rs1215050 0.765 rs471500 chr4:98714820 T/C cg05340658 chr4:99064831 C4orf37 0.47 6.96 0.36 1.84e-11 Waist-to-hip ratio adjusted for body mass index; CRC cis rs597539 0.616 rs473997 chr11:68639481 C/T cg21963583 chr11:68658836 MRPL21 0.64 11.37 0.53 1.73e-25 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC trans rs13046373 0.905 rs4816372 chr21:32077414 A/T cg16511076 chr4:48887480 OCIAD2 -0.41 -6.64 -0.34 1.26e-10 HDL cholesterol; CRC cis rs9467773 0.620 rs2451738 chr6:26618459 A/T cg09904177 chr6:26538194 HMGN4 -0.7 -10.92 -0.52 7.03e-24 Intelligence (multi-trait analysis); CRC cis rs9399135 0.933 rs9389262 chr6:135376409 G/T cg22676075 chr6:135203613 NA 0.4 6.18 0.32 1.94e-9 Red blood cell count; CRC cis rs8180040 1.000 rs2159400 chr3:47375890 T/C cg02527881 chr3:46936655 PTH1R 0.39 7.1 0.36 7.61e-12 Colorectal cancer; CRC cis rs4588572 0.643 rs10063742 chr5:77759362 A/G cg11446398 chr5:77624930 NA 0.47 6.3 0.33 9.63e-10 Triglycerides; CRC cis rs3617 0.573 rs9825230 chr3:52901974 G/A cg11645453 chr3:52864694 ITIH4 0.35 6.47 0.34 3.49e-10 Red blood cell count;Autism spectrum disorder or schizophrenia; CRC trans rs9929218 0.954 rs7186333 chr16:68815838 T/A cg04657470 chr2:198365150 HSPE1;HSPD1 -0.81 -11.29 -0.53 3.45e-25 Colorectal cancer; CRC cis rs57590327 0.508 rs10511101 chr3:81950302 A/C cg07356753 chr3:81810745 GBE1 -0.59 -8.01 -0.4 2e-14 Extraversion; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg14358451 chr1:156698811 C1orf66;ISG20L2 0.42 6.13 0.32 2.57e-9 Intelligence (multi-trait analysis); CRC cis rs4713118 0.955 rs9380010 chr6:27683572 A/G cg03623178 chr6:28175578 NA 0.63 8.4 0.42 1.36e-15 Parkinson's disease; CRC cis rs1506636 0.962 rs1506640 chr7:123349627 T/G cg03229431 chr7:123269106 ASB15 -0.73 -11.74 -0.54 7.95e-27 Plateletcrit;Platelet count; CRC cis rs10504229 0.728 rs72650855 chr8:58152570 A/G cg24829409 chr8:58192753 C8orf71 -0.58 -7.96 -0.4 2.86e-14 Developmental language disorder (linguistic errors); CRC cis rs9733 0.596 rs6690725 chr1:150632322 T/C cg18016565 chr1:150552671 MCL1 0.46 6.74 0.35 6.91e-11 Tonsillectomy; CRC cis rs6691722 0.503 rs3765431 chr1:24706410 T/C cg02336364 chr1:24764700 NIPAL3 0.37 6.23 0.32 1.44e-9 Response to interferon beta in multiple sclerosis; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg09414045 chr1:110162465 AMPD2 0.48 8.07 0.41 1.36e-14 Liver disease severity in Alagille syndrome; CRC cis rs2882667 0.858 rs11750382 chr5:138456994 A/G cg04439458 chr5:138467593 SIL1 0.34 5.78 0.3 1.77e-8 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs7959452 0.649 rs4761239 chr12:69776886 T/A cg22834771 chr12:69754056 YEATS4 -0.53 -7.92 -0.4 3.8e-14 Blood protein levels; CRC cis rs7617773 0.817 rs6800492 chr3:48323890 G/A cg11946769 chr3:48343235 NME6 0.64 8.85 0.44 5.61e-17 Coronary artery disease; CRC cis rs72634258 0.554 rs1012477 chr1:7858135 C/G cg26816564 chr1:7831052 VAMP3 -0.83 -9.93 -0.48 1.74e-20 Inflammatory bowel disease; CRC cis rs4319547 0.695 rs4758645 chr12:122946487 G/A cg23029597 chr12:123009494 RSRC2 -0.5 -6.82 -0.35 4.3e-11 Body mass index; CRC cis rs4474465 0.850 rs10751294 chr11:78253303 T/A cg27205649 chr11:78285834 NARS2 0.5 6.34 0.33 7.74e-10 Alzheimer's disease (survival time); CRC cis rs4927850 1.000 rs7627868 chr3:195753473 A/T cg12923728 chr3:195709715 SDHAP1 -0.7 -10.9 -0.52 7.9e-24 Pancreatic cancer; CRC cis rs4713118 0.824 rs7759217 chr6:27730463 A/G cg02683197 chr6:28174875 NA 0.63 8.19 0.41 5.64e-15 Parkinson's disease; CRC cis rs875971 0.964 rs60193905 chr7:65971260 A/G cg11764359 chr7:65958608 NA 0.62 10.09 0.49 4.83e-21 Aortic root size; CRC cis rs8067545 0.750 rs11867585 chr17:19992607 A/G cg13482628 chr17:19912719 NA 0.46 7.42 0.38 9.93e-13 Schizophrenia; CRC cis rs34779708 0.931 rs35997236 chr10:35376690 C/T cg03585969 chr10:35415529 CREM 0.67 8.87 0.44 4.78e-17 Inflammatory bowel disease;Crohn's disease; CRC cis rs3749237 0.595 rs11130199 chr3:49538799 T/C cg03060546 chr3:49711283 APEH 0.61 10.46 0.5 2.59e-22 Resting heart rate; CRC cis rs4243830 0.850 rs4908910 chr1:6599362 T/A cg05709478 chr1:6581295 PLEKHG5 -0.5 -5.69 -0.3 2.83e-8 Body mass index; CRC trans rs703108 0.731 rs7898954 chr10:22323646 A/G cg27161523 chr12:51591966 POU6F1 0.44 6.24 0.33 1.36e-9 Monocyte percentage of white cells; CRC cis rs881375 0.967 rs2416806 chr9:123690292 G/C cg00246817 chr9:123691163 NA -0.43 -5.6 -0.3 4.53e-8 Rheumatoid arthritis; CRC cis rs7615952 0.599 rs7652883 chr3:125707977 T/G cg02807482 chr3:125708958 NA -0.46 -6.0 -0.31 5.14e-9 Blood pressure (smoking interaction); CRC cis rs2404602 0.716 rs67920045 chr15:76800084 G/A cg23625390 chr15:77176239 SCAPER 0.5 7.18 0.37 4.65e-12 Blood metabolite levels; CRC cis rs12477438 0.798 rs6740035 chr2:99576578 C/A cg26064155 chr2:99771622 LIPT1;TSGA10 -0.75 -10.56 -0.5 1.23e-22 Chronic sinus infection; CRC cis rs6840360 0.615 rs10001603 chr4:152647577 T/A cg09659197 chr4:152720779 NA 0.4 8.23 0.41 4.47e-15 Intelligence (multi-trait analysis); CRC cis rs1728785 1.000 rs7192341 chr16:68569224 G/C cg02972257 chr16:68554789 NA -0.62 -7.16 -0.37 5.24e-12 Ulcerative colitis; CRC cis rs7618915 0.547 rs13085331 chr3:52627486 G/C cg11645453 chr3:52864694 ITIH4 0.35 6.13 0.32 2.58e-9 Bipolar disorder; CRC trans rs9393777 0.778 rs13212921 chr6:27205422 C/T cg06606381 chr12:133084897 FBRSL1 -0.91 -6.95 -0.36 1.91e-11 Intelligence (multi-trait analysis); CRC cis rs2549003 1.000 rs7734334 chr5:131815004 C/A cg02551604 chr5:131831745 NA -0.54 -8.38 -0.42 1.58e-15 Asthma (sex interaction); CRC trans rs12599106 0.792 rs11648801 chr16:34360980 C/T cg05064044 chr6:292385 DUSP22 -0.6 -8.22 -0.41 4.88e-15 Menopause (age at onset); CRC cis rs7666738 0.830 rs2865951 chr4:99040191 C/T cg17366294 chr4:99064904 C4orf37 0.43 7.19 0.37 4.48e-12 Colonoscopy-negative controls vs population controls; CRC cis rs600806 0.854 rs11142 chr1:109897103 A/G cg23032129 chr1:109941072 SORT1 -0.27 -5.76 -0.3 1.94e-8 Intelligence (multi-trait analysis); CRC cis rs6951245 1.000 rs80031817 chr7:1096793 T/C cg03188948 chr7:1209495 NA 0.66 6.94 0.36 2.04e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs9463078 0.547 rs2038555 chr6:44744033 A/G cg25276700 chr6:44698697 NA 0.3 7.76 0.39 1.09e-13 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; CRC cis rs9903692 0.954 rs4794448 chr17:46180807 C/T cg21215337 chr17:46176117 CBX1 -0.43 -7.95 -0.4 2.95e-14 Pulse pressure; CRC cis rs10193935 0.901 rs13384885 chr2:42536646 G/C cg27598129 chr2:42591480 NA -0.71 -8.24 -0.41 4.02e-15 Colonoscopy-negative controls vs population controls; CRC cis rs78456975 1.000 rs13422995 chr2:1553554 C/A cg01028140 chr2:1542097 TPO -0.55 -5.74 -0.3 2.15e-8 Placebo response in major depressive disorder (% change in symptom score); CRC cis rs977987 0.966 rs8055490 chr16:75497135 C/T cg03315344 chr16:75512273 CHST6 0.57 9.73 0.47 7.95e-20 Dupuytren's disease; CRC cis rs2281845 0.929 rs6704363 chr1:201096383 A/G cg22815214 chr1:201083145 CACNA1S 0.63 10.32 0.49 8.07e-22 Permanent tooth development; CRC cis rs4588572 0.644 rs10061149 chr5:77744201 G/A cg11547950 chr5:77652471 NA -0.48 -7.03 -0.36 1.19e-11 Triglycerides; CRC cis rs2952156 0.920 rs2952152 chr17:37832735 T/C cg11212589 chr17:38028394 ZPBP2 0.35 6.29 0.33 9.93e-10 Asthma; CRC cis rs9443645 0.670 rs79209669 chr6:79719623 C/G cg09184832 chr6:79620586 NA -0.51 -9.28 -0.46 2.3e-18 Intelligence (multi-trait analysis); CRC cis rs4072980 0.545 rs11210870 chr1:38449910 T/C cg18451016 chr1:38461880 NA -0.39 -5.69 -0.3 2.76e-8 Coronary artery disease; CRC cis rs733592 0.560 rs2158515 chr12:48507668 T/C cg21466736 chr12:48725269 NA 0.52 8.13 0.41 8.75e-15 Plateletcrit; CRC cis rs881375 0.967 rs1008381 chr9:123681116 T/C cg09586646 chr9:123605570 PSMD5;LOC253039 0.51 6.92 0.36 2.4e-11 Rheumatoid arthritis; CRC trans rs10242455 0.702 rs73713507 chr7:99138603 G/A cg09045935 chr12:6379348 NA 1.13 8.15 0.41 7.74e-15 Blood metabolite levels; CRC cis rs10504229 0.906 rs114810777 chr8:58185298 A/G cg02290350 chr8:58132656 NA -0.43 -6.03 -0.32 4.3e-9 Developmental language disorder (linguistic errors); CRC cis rs1799949 0.859 rs11657004 chr17:41442751 A/G cg25072359 chr17:41440525 NA 0.51 8.16 0.41 7.28e-15 Menopause (age at onset); CRC cis rs597539 0.652 rs514296 chr11:68654182 G/T cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.88 15.5 0.65 4.4e-41 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs7274811 0.554 rs6120299 chr20:32133491 T/G cg03904042 chr20:32255491 NECAB3;C20orf134 -0.46 -6.26 -0.33 1.23e-9 Height; CRC cis rs9894429 0.646 rs9905639 chr17:79614154 A/G cg18240062 chr17:79603768 NPLOC4 0.46 7.26 0.37 2.81e-12 Eye color traits; CRC cis rs12472274 0.941 rs2880131 chr2:239089151 A/C cg17459225 chr2:239074497 NA 0.87 15.38 0.65 1.31e-40 Phospholipid levels (plasma); CRC cis rs7927771 0.832 rs4752994 chr11:47411065 A/T cg18512352 chr11:47633146 NA 0.39 7.37 0.38 1.4e-12 Subjective well-being; CRC cis rs1862618 0.853 rs832568 chr5:56153776 G/A cg20203395 chr5:56204925 C5orf35 -0.73 -8.6 -0.43 3.41e-16 Initial pursuit acceleration; CRC cis rs9462027 0.583 rs2744974 chr6:34579431 C/T cg07306190 chr6:34760872 UHRF1BP1 -0.35 -6.05 -0.32 3.88e-9 Systemic lupus erythematosus; CRC cis rs9488822 0.676 rs12202181 chr6:116327102 A/G cg18764771 chr6:116381957 FRK 0.25 7.0 0.36 1.42e-11 Cholesterol, total;LDL cholesterol; CRC cis rs1728785 0.901 rs11865339 chr16:68565296 C/T cg02972257 chr16:68554789 NA -0.58 -7.08 -0.36 9.03e-12 Ulcerative colitis; CRC cis rs875971 1.000 rs778699 chr7:65868290 G/A cg18912574 chr7:65842487 NCRNA00174 0.36 6.18 0.32 1.88e-9 Aortic root size; CRC cis rs6586163 0.872 rs7069841 chr10:90741955 T/C cg13456138 chr10:90753195 FAS -0.44 -6.58 -0.34 1.84e-10 Chronic lymphocytic leukemia; CRC cis rs2243480 1.000 rs2462569 chr7:65474846 C/T cg18252515 chr7:66147081 NA 1.01 11.83 0.55 3.79e-27 Diabetic kidney disease; CRC cis rs8031584 0.678 rs8035703 chr15:31168472 T/C cg14829155 chr15:31115871 NA -0.65 -10.22 -0.49 1.84e-21 Huntington's disease progression; CRC cis rs1552244 0.935 rs41520445 chr3:10153141 A/C cg16606324 chr3:10149918 C3orf24 -0.72 -9.6 -0.47 2.14e-19 Alzheimer's disease; CRC cis rs965469 1.000 rs6051807 chr20:3350485 A/G cg25506879 chr20:3388711 C20orf194 -0.41 -5.85 -0.31 1.19e-8 IFN-related cytopenia; CRC cis rs780096 0.526 rs809058 chr2:27616790 T/C cg17158414 chr2:27665306 KRTCAP3 -0.28 -6.0 -0.31 5.29e-9 Total body bone mineral density; CRC cis rs2811415 0.597 rs9822021 chr3:127735238 T/C cg13719885 chr3:127795394 NA -0.38 -5.75 -0.3 2.06e-8 Lung function (FEV1/FVC); CRC cis rs4803480 0.872 rs10420470 chr19:42073433 A/G cg08478046 chr19:42093086 CEACAM21 -0.39 -6.6 -0.34 1.64e-10 Schizophrenia; CRC cis rs3736594 1.000 rs3736594 chr2:27995781 A/C cg27432699 chr2:27873401 GPN1 -0.58 -8.11 -0.41 1.05e-14 Fasting blood glucose;Fasting blood glucose (BMI interaction); CRC cis rs651907 0.557 rs3094295 chr3:101401995 T/C cg11279151 chr3:101281821 RG9MTD1 -0.57 -7.73 -0.39 1.33e-13 Colorectal cancer; CRC cis rs117623576 0.816 rs72784871 chr10:32445169 T/A cg03047570 chr10:32398778 NA -0.66 -6.17 -0.32 1.98e-9 Anti-saccade response; CRC cis rs13191362 0.810 rs34714603 chr6:163008078 C/T cg23758597 chr6:163146217 PARK2 -0.51 -5.9 -0.31 8.81e-9 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs7258465 1.000 rs271623 chr19:18628947 A/G cg01065977 chr19:18549689 ISYNA1 -0.37 -5.66 -0.3 3.3e-8 Breast cancer; CRC cis rs929354 0.772 rs1182438 chr7:157027438 G/A cg05182265 chr7:156933206 UBE3C 0.76 14.57 0.63 1.95e-37 Body mass index; CRC cis rs7236492 0.577 rs7236190 chr18:77198217 T/C cg15644404 chr18:77186268 NFATC1 -0.45 -6.41 -0.33 5e-10 Inflammatory bowel disease;Crohn's disease; CRC cis rs853679 0.517 rs17774663 chr6:28120898 G/A cg12172441 chr6:28176163 NA 0.64 7.53 0.38 5.03e-13 Depression; CRC cis rs7772486 0.754 rs6932863 chr6:146021255 A/T cg23711669 chr6:146136114 FBXO30 -0.75 -12.86 -0.58 6.25e-31 Lobe attachment (rater-scored or self-reported); CRC cis rs1816752 0.905 rs11839006 chr13:25010031 T/C cg02811702 chr13:24901961 NA 0.47 6.62 0.34 1.49e-10 Obesity-related traits; CRC cis rs7762018 1.000 rs6459657 chr6:170136454 A/G cg24289452 chr6:170231220 NA -0.54 -6.01 -0.31 5.05e-9 Thiazide-induced adverse metabolic effects in hypertensive patients; CRC cis rs9733 0.596 rs11204704 chr1:150671630 T/C cg15448220 chr1:150897856 SETDB1 0.46 6.54 0.34 2.29e-10 Tonsillectomy; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg12176476 chr15:75747445 SIN3A 0.43 6.05 0.32 4.02e-9 Anxiety disorder; CRC trans rs4332037 0.506 rs62442924 chr7:1989976 C/T cg11693508 chr17:37793320 STARD3 0.56 6.66 0.34 1.12e-10 Bipolar disorder; CRC cis rs1572438 0.862 rs4959467 chr6:857977 G/C cg13447295 chr6:887704 NA -0.42 -6.18 -0.32 1.88e-9 Aging; CRC cis rs11098499 0.913 rs10010696 chr4:120164303 T/C cg09307838 chr4:120376055 NA 0.61 9.34 0.46 1.48e-18 Corneal astigmatism; CRC cis rs7412746 0.658 rs4970987 chr1:150949682 T/C cg15448220 chr1:150897856 SETDB1 0.55 7.8 0.4 8.21e-14 Melanoma; CRC cis rs2019216 0.967 rs2342216 chr17:21910379 A/C cg05591447 chr17:21909280 FLJ36000 -0.33 -6.74 -0.35 7.1e-11 Pelvic organ prolapse; CRC cis rs7615952 0.688 rs17334074 chr3:125540460 A/G cg05084668 chr3:125655381 ALG1L 0.4 5.69 0.3 2.87e-8 Blood pressure (smoking interaction); CRC cis rs6735179 0.648 rs10469992 chr2:1760091 A/G cg19300414 chr2:1746591 PXDN -0.34 -5.97 -0.31 6.16e-9 Response to antipsychotic treatment; CRC cis rs929354 1.000 rs1182377 chr7:157048403 T/C cg16102536 chr7:156981717 UBE3C -0.37 -6.3 -0.33 9.6e-10 Body mass index; CRC cis rs4713118 0.824 rs9468225 chr6:27745719 T/G cg02683197 chr6:28174875 NA 0.66 8.47 0.42 8.25e-16 Parkinson's disease; CRC cis rs2228479 0.850 rs12597299 chr16:89822364 C/A cg06656553 chr16:89960601 TCF25 -0.7 -5.76 -0.3 1.93e-8 Skin colour saturation; CRC cis rs4664308 0.935 rs6731260 chr2:160977769 A/G cg03641300 chr2:160917029 PLA2R1 -0.74 -11.98 -0.55 1.11e-27 Idiopathic membranous nephropathy; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg12218697 chr1:86042661 DDAH1 0.43 5.96 0.31 6.46e-9 Response to antipsychotic treatment; CRC cis rs877282 0.853 rs12777155 chr10:754731 G/C cg17470449 chr10:769945 NA 0.61 7.96 0.4 2.78e-14 Uric acid levels; CRC trans rs747782 0.582 rs7949865 chr11:48346202 A/C cg03929089 chr4:120376271 NA -0.68 -6.64 -0.34 1.34e-10 Intraocular pressure; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg15573783 chr19:45927056 ERCC1 0.39 6.21 0.32 1.59e-9 Liver disease severity in Alagille syndrome; CRC cis rs782590 0.837 rs782585 chr2:55922930 C/T cg18811423 chr2:55921094 PNPT1 0.89 17.69 0.7 1.08e-49 Metabolic syndrome; CRC cis rs6662572 0.703 rs7548617 chr1:46365489 C/A cg08644498 chr1:46502608 NA -0.44 -6.85 -0.35 3.69e-11 Blood protein levels; CRC cis rs35110281 0.777 rs7276215 chr21:44990697 A/G cg04455712 chr21:45112962 RRP1B 0.43 8.3 0.42 2.68e-15 Mean corpuscular volume; CRC cis rs1550582 0.662 rs4909628 chr8:135502380 A/T cg17885191 chr8:135476712 NA -0.96 -12.6 -0.57 5.5e-30 Educational attainment; CRC trans rs1814175 0.669 rs10839315 chr11:49654406 G/A cg21153622 chr11:89784906 NA -0.44 -7.16 -0.37 5.41e-12 Height; CRC cis rs7945705 1.000 rs7937298 chr11:8867509 G/C cg21881798 chr11:8931708 C11orf17;ST5 0.62 9.2 0.45 4.08e-18 Hemoglobin concentration; CRC cis rs929354 0.772 rs6971896 chr7:156978412 C/T cg05182265 chr7:156933206 UBE3C -0.76 -14.52 -0.62 3.01e-37 Body mass index; CRC cis rs6840360 0.573 rs10024721 chr4:152265331 G/A cg09659197 chr4:152720779 NA 0.32 6.31 0.33 8.78e-10 Intelligence (multi-trait analysis); CRC cis rs7618915 0.501 rs9917834 chr3:52634619 A/C cg10802521 chr3:52805072 NEK4 -0.58 -9.07 -0.45 1.13e-17 Bipolar disorder; CRC cis rs66573146 1.000 rs59683609 chr4:6964910 C/G cg00086871 chr4:6988644 TBC1D14 1.01 7.58 0.39 3.49e-13 Granulocyte percentage of myeloid white cells; CRC cis rs644799 0.544 rs1727165 chr11:95521648 A/G cg03916912 chr11:95522834 CEP57;FAM76B 0.7 11.58 0.54 2.93e-26 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC trans rs10242455 0.702 rs73403290 chr7:99157828 C/T cg09045935 chr12:6379348 NA 1.14 8.91 0.44 3.66e-17 Blood metabolite levels; CRC cis rs35306767 0.622 rs66462130 chr10:1022108 C/T cg26597838 chr10:835615 NA 0.95 10.6 0.5 8.78e-23 Eosinophil percentage of granulocytes; CRC trans rs9393777 0.778 rs66841633 chr6:27382386 G/T cg06606381 chr12:133084897 FBRSL1 -1.01 -7.01 -0.36 1.36e-11 Intelligence (multi-trait analysis); CRC cis rs2882667 0.898 rs10058347 chr5:138361358 G/A cg04439458 chr5:138467593 SIL1 -0.33 -6.01 -0.31 4.85e-9 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs425277 0.628 rs3107147 chr1:2048729 G/A cg04315214 chr1:2043799 PRKCZ 0.54 9.83 0.48 3.58e-20 Height; CRC cis rs59104589 0.959 rs3771555 chr2:242322680 C/T cg10021735 chr2:242295487 FARP2 -0.42 -5.96 -0.31 6.5e-9 Fibrinogen levels; CRC cis rs1707322 0.752 rs4660313 chr1:46110841 A/G cg03146154 chr1:46216737 IPP -0.67 -9.82 -0.48 4.01e-20 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs8180040 0.726 rs2305634 chr3:47043538 A/G cg10298567 chr3:47292165 KIF9 0.39 6.01 0.31 4.97e-9 Colorectal cancer; CRC cis rs12762955 0.561 rs7918118 chr10:1042823 C/A cg20503657 chr10:835505 NA -0.48 -6.64 -0.34 1.3e-10 Response to angiotensin II receptor blocker therapy; CRC cis rs9534288 0.700 rs7331032 chr13:46609040 C/T cg15192986 chr13:46630673 CPB2 -0.69 -10.15 -0.49 3.07e-21 Blood protein levels; CRC cis rs2456568 0.803 rs10831141 chr11:93640728 C/T cg26875233 chr11:93583750 C11orf90 -0.31 -6.02 -0.32 4.6e-9 Response to serotonin reuptake inhibitors in major depressive disorder; CRC cis rs3820928 0.605 rs6748311 chr2:227792530 T/A cg11843606 chr2:227700838 RHBDD1 -0.46 -7.14 -0.37 6.04e-12 Pulmonary function; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg26732287 chr11:102322742 TMEM123 0.44 6.5 0.34 3.03e-10 Intelligence (multi-trait analysis); CRC trans rs10208940 0.843 rs7608248 chr2:68851403 C/T cg00078746 chr14:91700401 GPR68 0.44 6.01 0.31 4.8e-9 Urate levels in lean individuals; CRC cis rs12893668 0.603 rs61637848 chr14:104096031 C/T cg24130564 chr14:104152367 KLC1 -0.43 -5.63 -0.3 3.86e-8 Reticulocyte count; CRC cis rs13161895 0.702 rs12652904 chr5:179496422 C/T cg02702477 chr5:179499311 RNF130 0.83 8.39 0.42 1.43e-15 LDL cholesterol; CRC cis rs6835098 1.000 rs28477433 chr4:174085820 T/C cg08422745 chr4:174089978 GALNT7 -0.96 -16.27 -0.67 4.46e-44 Dementia and core Alzheimer's disease neuropathologic changes; CRC cis rs10512697 0.803 rs34134373 chr5:3574462 C/A cg19473799 chr5:3511975 NA -0.74 -5.72 -0.3 2.46e-8 Immune response to smallpox vaccine (IL-6); CRC cis rs763014 0.966 rs4984904 chr16:680809 C/G cg03804128 chr16:635623 NA 0.29 6.75 0.35 6.86e-11 Height; CRC cis rs6502050 0.799 rs34448080 chr17:80121275 A/G cg02741985 chr17:80059408 CCDC57 0.43 7.15 0.37 5.59e-12 Life satisfaction; CRC trans rs2303319 0.582 rs62187608 chr2:162431138 T/G cg12500891 chr11:57225987 NA -0.67 -5.97 -0.31 6e-9 Cognitive function; CRC cis rs736408 0.511 rs12637632 chr3:52708073 A/T cg11645453 chr3:52864694 ITIH4 0.36 6.21 0.32 1.64e-9 Bipolar disorder; CRC cis rs7647973 1.000 rs6785045 chr3:49435243 G/C cg20833759 chr3:49053208 WDR6;DALRD3 -0.55 -8.2 -0.41 5.38e-15 Menarche (age at onset); CRC cis rs4638749 0.627 rs4676185 chr2:108841908 G/C cg25838818 chr2:108905173 SULT1C2 -0.33 -5.61 -0.3 4.35e-8 Blood pressure; CRC cis rs4604732 0.588 rs6677477 chr1:247629411 C/T cg02104434 chr1:247694406 LOC148824;OR2C3 0.53 8.11 0.41 1e-14 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CRC cis rs9549328 0.565 rs35371379 chr13:113616715 T/C cg17524180 chr13:113633600 MCF2L 0.52 9.35 0.46 1.43e-18 Systolic blood pressure; CRC trans rs11088226 0.581 rs2833862 chr21:33884390 A/G cg09050820 chr6:167586206 TCP10L2 0.52 7.32 0.37 1.93e-12 Gastritis; CRC trans rs9561329 0.800 rs12430278 chr13:94035424 C/T cg23072629 chr2:239195537 PER2 0.34 6.41 0.33 4.99e-10 Neuroticism (age interaction); CRC trans rs7395662 0.895 rs7924481 chr11:48582457 A/G cg21153622 chr11:89784906 NA -0.46 -7.35 -0.38 1.54e-12 HDL cholesterol; CRC cis rs780094 0.500 rs4666002 chr2:27840640 G/C cg27432699 chr2:27873401 GPN1 0.46 5.97 0.31 6.14e-9 Calcium levels;Fasting blood insulin;Metabolic traits;Triglyceride levels;Fasting plasma glucose;Urate levels in overweight individuals;Urate levels in obese individuals;Uric acid levels;Height;Age-related diseases, mortality and associated endophenotypes;Renal underexcretion gout;Fasting blood glucose (BMI interaction);Urate levels;Gondoic acid (20:1n-9) levels;Fasting blood insulin (BMI interaction);Triglycerides;Plasma omega-3 polyunsaturated fatty acid levels (docosapentaenoic acid);Type 2 diabetes;Nonalcoholic fatty liver disease;Hypertriglyceridemia;C-reactive protein;Age-related disease endophenotypes;LDL cholesterol;Metabolic syndrome;Crohn's disease;Alcohol consumption (drinks per week);Homeostasis model assessment of insulin resistance;Alcohol consumption;Red blood cell count;Fasting blood glucose; CRC cis rs7772486 0.720 rs1890171 chr6:146072114 T/C cg13319975 chr6:146136371 FBXO30 0.46 6.85 0.35 3.63e-11 Lobe attachment (rater-scored or self-reported); CRC cis rs10504229 0.593 rs10504216 chr8:57981470 G/A cg24829409 chr8:58192753 C8orf71 -0.55 -6.48 -0.34 3.39e-10 Developmental language disorder (linguistic errors); CRC cis rs860295 0.702 rs12239100 chr1:155428476 C/A cg02153340 chr1:155202674 NA -0.58 -6.92 -0.36 2.44e-11 Body mass index; CRC cis rs8141529 0.719 rs2097461 chr22:29191879 T/C cg15103426 chr22:29168792 CCDC117 0.61 8.83 0.44 6.28e-17 Lymphocyte counts; CRC cis rs910316 1.000 rs876403 chr14:75602834 A/T cg11812906 chr14:75593930 NEK9 0.63 10.07 0.49 5.55e-21 Height; CRC cis rs9467711 0.591 rs28360595 chr6:26030044 A/G cg08501292 chr6:25962987 TRIM38 1.09 9.37 0.46 1.2e-18 Autism spectrum disorder or schizophrenia; CRC cis rs8060686 0.641 rs7193935 chr16:68071147 C/T cg08314208 chr16:67682810 RLTPR -0.5 -6.04 -0.32 4.22e-9 HDL cholesterol;Metabolic syndrome; CRC cis rs10484885 0.752 rs72921948 chr6:90582560 T/C cg13799429 chr6:90582589 CASP8AP2 -0.83 -12.7 -0.57 2.5e-30 QRS interval (sulfonylurea treatment interaction); CRC cis rs10894147 0.709 rs1030467 chr11:129744252 T/C cg27255275 chr11:129766154 NFRKB 0.4 5.79 0.3 1.64e-8 Obesity-related traits; CRC cis rs4713118 0.662 rs9380046 chr6:28030499 T/C cg18032046 chr6:28092343 ZSCAN16 -0.49 -6.18 -0.32 1.87e-9 Parkinson's disease; CRC cis rs3818285 0.679 rs612155 chr10:111630731 C/G cg00817464 chr10:111662876 XPNPEP1 0.62 10.92 0.52 6.69e-24 Superior crus of antihelix expression; CRC cis rs3087591 0.960 rs9903754 chr17:29634468 G/A cg24425628 chr17:29625626 OMG;NF1 -0.89 -16.85 -0.68 2.31e-46 Hip circumference; CRC cis rs4665809 0.652 rs6728090 chr2:26524726 C/T cg25036284 chr2:26402008 FAM59B -0.47 -6.27 -0.33 1.15e-9 Gut microbiome composition (summer); CRC cis rs72945132 0.882 rs7945389 chr11:70158876 C/A cg00319359 chr11:70116639 PPFIA1 0.68 7.51 0.38 5.61e-13 Coronary artery disease; CRC cis rs7772486 0.790 rs9376971 chr6:146259505 C/T cg13319975 chr6:146136371 FBXO30 0.41 6.24 0.33 1.32e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs1552244 0.882 rs17081288 chr3:10042113 A/G cg18598329 chr3:10140678 FANCD2;C3orf24 -0.81 -10.55 -0.5 1.36e-22 Alzheimer's disease; CRC cis rs68170813 0.559 rs75672288 chr7:107031549 G/C cg02696742 chr7:106810147 HBP1 -0.59 -6.22 -0.32 1.52e-9 Coronary artery disease; CRC trans rs875971 0.660 rs2191268 chr7:66110224 C/T cg04180668 chr6:163148903 PARK2;PACRG -0.41 -6.3 -0.33 9.29e-10 Aortic root size; CRC cis rs72781680 1.000 rs72796358 chr2:24160132 T/A cg08917208 chr2:24149416 ATAD2B 0.93 9.42 0.46 8.51e-19 Lymphocyte counts; CRC cis rs12476592 0.602 rs262506 chr2:63863022 A/G cg10828910 chr2:63850056 LOC388955 0.49 6.03 0.32 4.37e-9 Childhood ear infection; CRC cis rs9715521 0.935 rs72634625 chr4:59836434 T/A cg11281224 chr4:60001000 NA -0.38 -5.65 -0.3 3.53e-8 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs1223397 0.938 rs3734878 chr6:13288850 C/T cg06879394 chr6:13274151 PHACTR1 0.53 6.22 0.32 1.54e-9 Blood pressure; CRC cis rs6754311 0.731 rs4954490 chr2:136608231 G/A cg25344623 chr2:136566232 LCT 0.34 6.15 0.32 2.2e-9 Mosquito bite size; CRC cis rs250677 0.687 rs250671 chr5:148446523 T/C cg23229984 chr5:148520753 ABLIM3 0.5 6.95 0.36 1.96e-11 Breast cancer; CRC cis rs780096 0.506 rs2288155 chr2:27714526 T/C cg02592271 chr2:27665507 KRTCAP3 -0.27 -5.94 -0.31 7.17e-9 Total body bone mineral density; CRC cis rs2997447 0.846 rs61775422 chr1:26395898 C/T cg24519413 chr1:26490540 NA 0.46 5.66 0.3 3.22e-8 QRS complex (12-leadsum); CRC cis rs77633900 0.614 rs2468122 chr15:76918686 A/C cg21673338 chr15:77095150 SCAPER -0.66 -6.84 -0.35 3.88e-11 Non-glioblastoma glioma;Glioma; CRC cis rs6479527 0.806 rs6479522 chr9:96748822 G/A cg14459158 chr9:96720562 NA 0.41 7.52 0.38 5.11e-13 Esophageal adenocarcinoma; CRC cis rs9807989 0.811 rs7608638 chr2:102970289 A/G cg03938978 chr2:103052716 IL18RAP 0.37 5.97 0.31 6.2e-9 Asthma; CRC cis rs7923609 0.841 rs7920036 chr10:65293860 T/C cg08743896 chr10:65200160 JMJD1C -0.41 -5.78 -0.3 1.74e-8 Educational attainment;Liver enzyme levels (alkaline phosphatase); CRC cis rs6952808 0.798 rs28970524 chr7:1927484 C/T cg00106254 chr7:1943704 MAD1L1 -0.53 -7.8 -0.39 8.41e-14 Bipolar disorder and schizophrenia; CRC cis rs7487075 0.751 rs7310869 chr12:46665386 G/C cg22049899 chr12:47219821 SLC38A4 0.32 6.12 0.32 2.65e-9 Itch intensity from mosquito bite; CRC cis rs12541635 0.966 rs12544362 chr8:106976344 A/C cg10147462 chr8:107024639 NA 0.41 6.62 0.34 1.5e-10 Age of smoking initiation; CRC cis rs951366 0.789 rs1772148 chr1:205704580 A/T cg07167872 chr1:205819463 PM20D1 0.76 11.43 0.53 1.01e-25 Menarche (age at onset); CRC cis rs651907 0.535 rs11712309 chr3:101519097 T/C cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.59 7.86 0.4 5.42e-14 Colorectal cancer; CRC cis rs9447004 0.557 rs2173854 chr6:74426775 T/A cg03006477 chr6:74432658 CD109 0.36 6.34 0.33 7.53e-10 Blood protein levels;Calcium levels; CRC cis rs9399135 0.967 rs4896122 chr6:135295081 T/C cg24558204 chr6:135376177 HBS1L 0.5 7.82 0.4 7.14e-14 Red blood cell count; CRC cis rs9309711 0.666 rs6723101 chr2:3484443 T/C cg08493051 chr2:3487164 NA -0.39 -5.65 -0.3 3.48e-8 Neurofibrillary tangles; CRC cis rs9517313 0.565 rs9556978 chr13:99234648 G/A cg07423050 chr13:99094983 FARP1 -0.53 -7.5 -0.38 6.01e-13 Neuroticism; CRC cis rs7591163 0.959 rs11685995 chr2:228722008 T/C cg08034379 chr2:228736324 WDR69 -0.49 -6.75 -0.35 6.78e-11 Blood pressure; CRC trans rs11098499 0.954 rs10006877 chr4:120242793 C/T cg25214090 chr10:38739885 LOC399744 0.61 9.52 0.46 3.84e-19 Corneal astigmatism; CRC cis rs6502050 0.842 rs62079996 chr17:80076862 A/G cg11859384 chr17:80120422 CCDC57 0.37 5.82 0.31 1.43e-8 Life satisfaction; CRC trans rs11098499 0.909 rs17046118 chr4:120387496 T/G cg25214090 chr10:38739885 LOC399744 0.66 10.55 0.5 1.36e-22 Corneal astigmatism; CRC cis rs6582630 0.502 rs2204008 chr12:38439203 C/T cg13010199 chr12:38710504 ALG10B 0.47 6.12 0.32 2.65e-9 Drug-induced liver injury (flucloxacillin); CRC cis rs7726839 0.718 rs6887972 chr5:597274 C/G cg16447950 chr5:562315 NA -0.54 -8.11 -0.41 9.81e-15 Obesity-related traits; CRC cis rs7124681 0.584 rs12226590 chr11:47571808 T/C cg20307385 chr11:47447363 PSMC3 0.53 7.84 0.4 6.36e-14 Body mass index (joint analysis main effects and physical activity interaction);Body mass index;Body mass index in physically active individuals; CRC cis rs2243480 1.000 rs10950032 chr7:65738591 C/A cg25985355 chr7:65971099 NA 0.51 5.72 0.3 2.46e-8 Diabetic kidney disease; CRC cis rs939574 0.790 rs72955440 chr2:220091765 A/C cg00496455 chr2:220118770 TUBA4A;TUBA4B 0.91 8.44 0.42 1.06e-15 Platelet distribution width; CRC cis rs3772130 0.961 rs34667636 chr3:121353291 G/A cg20356878 chr3:121714668 ILDR1 0.49 7.65 0.39 2.22e-13 Cognitive performance; CRC cis rs7107356 1 rs7107356 chr11:47676170 A/G cg05585544 chr11:47624801 NA 0.32 5.61 0.3 4.27e-8 Neuroticism;Neuroticism (multi-trait analysis); CRC cis rs7223966 0.921 rs7225092 chr17:61864005 G/T cg05941027 chr17:61774174 LIMD2 0.36 6.31 0.33 9.08e-10 Hip circumference adjusted for BMI;Body mass index; CRC trans rs17685 0.753 rs10952840 chr7:75772878 C/T cg19862616 chr7:65841803 NCRNA00174 0.98 18.08 0.71 3.12e-51 Coffee consumption;Coffee consumption (cups per day); CRC trans rs61931739 0.500 rs7309931 chr12:34483471 A/C cg13010199 chr12:38710504 ALG10B 0.44 6.28 0.33 1.06e-9 Morning vs. evening chronotype; CRC cis rs9443645 0.901 rs10943605 chr6:79655477 G/A cg09184832 chr6:79620586 NA -0.51 -9.57 -0.47 2.63e-19 Intelligence (multi-trait analysis); CRC cis rs76993477 0.666 rs80355141 chr1:169712598 G/A cg03211132 chr1:169703751 SELE 0.58 5.7 0.3 2.72e-8 Tonsillectomy; CRC cis rs79387448 0.701 rs11465584 chr2:102982629 G/A cg09003973 chr2:102972529 NA 0.95 10.12 0.49 3.91e-21 Gut microbiota (bacterial taxa); CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg01956158 chr8:132916947 EFR3A 0.49 6.21 0.32 1.62e-9 Thyroid stimulating hormone; CRC cis rs9868809 0.505 rs28567949 chr3:48744560 G/A cg07636037 chr3:49044803 WDR6 -0.69 -6.65 -0.34 1.25e-10 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; CRC cis rs2075064 0.900 rs10760309 chr9:126792005 A/G cg14112217 chr9:126806003 NA 0.39 5.78 0.3 1.71e-8 Waist circumference; CRC cis rs9372498 0.505 rs9489493 chr6:118992323 T/C cg15382696 chr6:118971807 C6orf204 0.48 6.4 0.33 5.33e-10 Diastolic blood pressure; CRC cis rs3862030 0.720 rs12569526 chr10:104237007 A/G cg11453585 chr10:104263688 ACTR1A;SUFU -0.8 -14.4 -0.62 8.72e-37 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for body mass index; CRC cis rs853679 0.517 rs9393893 chr6:28109262 T/C cg12172441 chr6:28176163 NA 0.64 7.53 0.38 5.03e-13 Depression; CRC cis rs736408 0.812 rs1076425 chr3:52825462 A/G cg10802521 chr3:52805072 NEK4 -0.49 -6.65 -0.34 1.19e-10 Bipolar disorder; CRC cis rs875971 0.830 rs427973 chr7:65526648 C/A cg11764359 chr7:65958608 NA 0.58 9.04 0.45 1.39e-17 Aortic root size; CRC trans rs2303319 0.504 rs60495163 chr2:162408807 C/T cg27113153 chr11:123612418 ZNF202 -0.72 -6.16 -0.32 2.09e-9 Cognitive function; CRC cis rs11122272 0.701 rs2491402 chr1:231494338 T/C cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.5 -7.44 -0.38 8.8e-13 Hemoglobin concentration; CRC cis rs9300255 0.543 rs520088 chr12:123522150 C/G cg00376283 chr12:123451042 ABCB9 0.57 7.32 0.37 1.97e-12 Neutrophil percentage of white cells; CRC cis rs2243480 1.000 rs35421653 chr7:65363429 C/A cg12463550 chr7:65579703 CRCP 0.69 6.46 0.34 3.72e-10 Diabetic kidney disease; CRC cis rs2811415 0.597 rs9820563 chr3:127780871 A/G cg13719885 chr3:127795394 NA -0.39 -5.98 -0.31 5.78e-9 Lung function (FEV1/FVC); CRC cis rs7208859 0.623 rs9895785 chr17:29107708 C/T cg13385521 chr17:29058706 SUZ12P -0.75 -8.34 -0.42 1.99e-15 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC trans rs983332 0.512 rs17130131 chr1:88210458 G/A cg09221037 chr5:1523205 LPCAT1 -0.65 -6.12 -0.32 2.6e-9 Response to TNF antagonist treatment; CRC trans rs6703335 0.870 rs10803142 chr1:243598234 A/G cg25010444 chr12:123717480 C12orf65 0.43 5.99 0.31 5.58e-9 Schizophrenia;Schizophrenia, schizoaffective disorder or bipolar disorder; CRC cis rs9811920 0.809 rs1387647 chr3:99826942 T/G cg07805332 chr3:99536008 MIR548G;C3orf26 -0.39 -5.94 -0.31 7.31e-9 Axial length; CRC cis rs853679 0.769 rs7752448 chr6:28301099 A/G cg03623178 chr6:28175578 NA 0.8 7.45 0.38 8.56e-13 Depression; CRC cis rs4665809 1.000 rs6546767 chr2:26328746 A/G cg22920501 chr2:26401640 FAM59B -0.52 -6.97 -0.36 1.78e-11 Gut microbiome composition (summer); CRC trans rs11098499 0.954 rs67265404 chr4:120359270 C/T cg25214090 chr10:38739885 LOC399744 0.66 10.55 0.5 1.32e-22 Corneal astigmatism; CRC trans rs11098499 0.863 rs12498539 chr4:120468370 C/T cg25214090 chr10:38739885 LOC399744 0.65 10.45 0.5 2.9e-22 Corneal astigmatism; CRC cis rs6598955 0.616 rs11247890 chr1:26590182 G/A cg04990556 chr1:26633338 UBXN11 0.56 6.02 0.32 4.53e-9 Obesity-related traits; CRC cis rs763121 0.853 rs2064088 chr22:39053382 A/G cg06544989 chr22:39130855 UNC84B 0.45 6.86 0.35 3.39e-11 Menopause (age at onset); CRC cis rs7909074 1.000 rs10900128 chr10:45393201 G/T cg05187965 chr10:45406764 TMEM72 -0.36 -8.41 -0.42 1.29e-15 Mean corpuscular volume; CRC cis rs6604026 0.656 rs2774952 chr1:93355246 A/C cg17283838 chr1:93427260 FAM69A -0.43 -5.79 -0.3 1.61e-8 Multiple sclerosis; CRC cis rs1348850 0.872 rs10165785 chr2:178293295 C/T cg22681709 chr2:178499509 PDE11A -0.41 -7.49 -0.38 6.52e-13 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC trans rs916888 0.647 rs199449 chr17:44808902 G/A cg07870213 chr5:140052090 DND1 0.62 8.01 0.4 1.98e-14 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC trans rs637571 0.676 rs1151523 chr11:65665200 C/T cg17712092 chr4:129076599 LARP1B -0.74 -12.54 -0.57 9.67e-30 Eosinophil percentage of white cells; CRC cis rs6570726 0.791 rs12208812 chr6:145900924 T/G cg23711669 chr6:146136114 FBXO30 0.76 13.22 0.59 2.65e-32 Lobe attachment (rater-scored or self-reported); CRC cis rs9435341 0.860 rs12406721 chr1:107563243 G/T cg15468180 chr1:107600409 PRMT6 0.38 5.6 0.3 4.48e-8 Facial morphology (factor 21, depth of nasal alae); CRC cis rs34172651 0.917 rs200532 chr16:24756148 C/T cg06028605 chr16:24865363 SLC5A11 -0.4 -7.72 -0.39 1.44e-13 Intelligence (multi-trait analysis); CRC cis rs8078723 0.802 rs9303283 chr17:38192633 A/G cg17344932 chr17:38183730 MED24;SNORD124 -0.47 -7.18 -0.37 4.6e-12 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); CRC cis rs9914988 0.887 rs4795464 chr17:27146497 G/C cg20469991 chr17:27169893 C17orf63 -0.59 -7.19 -0.37 4.48e-12 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs7937682 0.889 rs521155 chr11:111492563 G/A cg09085632 chr11:111637200 PPP2R1B -0.98 -19.21 -0.73 1.09e-55 Primary sclerosing cholangitis; CRC cis rs748404 0.518 rs480108 chr15:43817406 T/C cg02155558 chr15:43621948 ADAL;LCMT2 0.52 7.42 0.38 9.79e-13 Lung cancer; CRC cis rs1267303 1.000 rs1267303 chr1:46990457 A/G cg25110126 chr1:46999211 NA 0.41 6.35 0.33 7.02e-10 Monobrow; CRC cis rs7827545 1.000 rs9644456 chr8:135568656 G/T cg17885191 chr8:135476712 NA 0.53 7.53 0.38 4.92e-13 Hypertension (SNP x SNP interaction); CRC cis rs9522267 0.535 rs56330641 chr13:112233538 C/T cg10483660 chr13:112241077 NA -0.48 -8.98 -0.44 2.09e-17 Hepatitis; CRC cis rs10504229 0.953 rs66509078 chr8:58174734 G/C cg24829409 chr8:58192753 C8orf71 -0.68 -11.34 -0.53 2.27e-25 Developmental language disorder (linguistic errors); CRC cis rs13108904 0.517 rs4974551 chr4:1336410 C/A cg15763984 chr4:1342303 KIAA1530 0.44 6.84 0.35 3.99e-11 Obesity-related traits; CRC cis rs9359856 0.529 rs72919922 chr6:90492997 G/A cg13799429 chr6:90582589 CASP8AP2 -0.75 -7.56 -0.38 4.15e-13 Bipolar disorder; CRC cis rs6570726 0.935 rs384453 chr6:145815145 G/C cg23711669 chr6:146136114 FBXO30 0.68 12.05 0.55 6.18e-28 Lobe attachment (rater-scored or self-reported); CRC cis rs62458065 0.513 rs787220 chr7:32581139 C/G cg20159608 chr7:32802032 NA -0.62 -8.01 -0.4 2.04e-14 Metabolite levels (HVA/MHPG ratio); CRC cis rs9875589 0.794 rs2117039 chr3:13963330 T/C cg19554555 chr3:13937349 NA 0.44 6.62 0.34 1.48e-10 Ovarian reserve; CRC cis rs801193 0.569 rs2013908 chr7:66121069 A/T cg18252515 chr7:66147081 NA 0.44 6.2 0.32 1.72e-9 Aortic root size; CRC cis rs68170813 0.559 rs12538769 chr7:106984288 C/T cg02696742 chr7:106810147 HBP1 -0.54 -5.99 -0.31 5.48e-9 Coronary artery disease; CRC cis rs9325144 0.600 rs12297194 chr12:38735803 A/G cg26384229 chr12:38710491 ALG10B -0.51 -7.79 -0.39 8.68e-14 Morning vs. evening chronotype; CRC cis rs11758351 0.929 rs6906367 chr6:26187125 C/T cg01420254 chr6:26195488 NA 0.49 6.02 0.31 4.73e-9 Gout;Renal underexcretion gout; CRC cis rs12681287 0.640 rs8635 chr8:87479810 C/T cg27223183 chr8:87520930 FAM82B -0.53 -7.52 -0.38 5.31e-13 Caudate activity during reward; CRC cis rs853679 0.517 rs4713135 chr6:28039586 G/A cg06470822 chr6:28175283 NA 0.98 13.08 0.59 8.77e-32 Depression; CRC cis rs4654899 0.802 rs2290381 chr1:21213271 C/A cg02927042 chr1:21476669 EIF4G3 -0.5 -8.03 -0.4 1.78e-14 Superior frontal gyrus grey matter volume; CRC cis rs780096 0.526 rs2911713 chr2:27640980 G/A cg12000995 chr2:27665139 KRTCAP3 -0.3 -6.29 -0.33 1.03e-9 Total body bone mineral density; CRC cis rs10789491 0.953 rs11211337 chr1:47133811 T/C cg15501359 chr1:47185051 KIAA0494 0.66 7.73 0.39 1.35e-13 Response to hepatitis C treatment; CRC trans rs61931739 0.500 rs7955933 chr12:34473608 A/G cg13010199 chr12:38710504 ALG10B 0.44 6.08 0.32 3.39e-9 Morning vs. evening chronotype; CRC trans rs61931739 0.534 rs1608911 chr12:34010249 T/C cg26384229 chr12:38710491 ALG10B 0.54 6.9 0.36 2.76e-11 Morning vs. evening chronotype; CRC cis rs2576037 0.501 rs8089938 chr18:44459497 C/T cg07643061 chr18:44555308 TCEB3C;TCEB3CL;KATNAL2 -0.37 -6.32 -0.33 8.69e-10 Personality dimensions; CRC cis rs9322193 0.962 rs17673294 chr6:150134993 G/A cg07701084 chr6:150067640 NUP43 0.49 6.83 0.35 4.08e-11 Lung cancer; CRC cis rs2243480 1.000 rs316307 chr7:65570171 C/T cg25985355 chr7:65971099 NA -0.49 -5.7 -0.3 2.69e-8 Diabetic kidney disease; CRC trans rs1455244 0.700 rs7229302 chr18:11508904 G/T cg13993802 chr11:107880029 CUL5 0.41 6.29 0.33 1.02e-9 Schizophrenia; CRC cis rs4285028 1.000 rs4285028 chr3:121660664 A/C cg20356878 chr3:121714668 ILDR1 -0.45 -6.55 -0.34 2.23e-10 Multiple sclerosis; CRC cis rs7945705 0.935 rs2653567 chr11:8889630 T/C cg21881798 chr11:8931708 C11orf17;ST5 -0.75 -12.74 -0.57 1.76e-30 Hemoglobin concentration; CRC cis rs7726839 0.574 rs12522955 chr5:639231 C/A cg17948913 chr5:572064 NA 0.5 5.75 0.3 2.02e-8 Obesity-related traits; CRC cis rs921968 0.541 rs490483 chr2:219429052 A/T cg02176678 chr2:219576539 TTLL4 0.53 8.45 0.42 9.24e-16 Mean corpuscular hemoglobin concentration; CRC cis rs4713118 0.786 rs200502 chr6:27788062 C/T cg08798685 chr6:27730294 NA -0.45 -5.89 -0.31 9.48e-9 Parkinson's disease; CRC cis rs1865760 0.508 rs9379820 chr6:26049924 T/C cg17691542 chr6:26056736 HIST1H1C 0.55 8.25 0.41 3.86e-15 Height; CRC cis rs9517313 0.592 rs11069311 chr13:99202101 G/T cg07423050 chr13:99094983 FARP1 -0.53 -7.55 -0.38 4.25e-13 Neuroticism; CRC cis rs6860806 0.507 rs2631372 chr5:131703578 C/G cg18758796 chr5:131593413 PDLIM4 0.41 6.58 0.34 1.83e-10 Breast cancer; CRC cis rs599083 0.569 rs685095 chr11:68170376 C/T cg16797656 chr11:68205561 LRP5 -0.4 -6.42 -0.33 4.66e-10 Bone mineral density (spine); CRC cis rs954108 0.809 rs1792022 chr13:29367967 A/G cg11788234 chr13:29393811 NA -0.42 -6.6 -0.34 1.64e-10 Obesity-related traits; CRC cis rs524281 0.817 rs10896097 chr11:65967953 A/C cg14036092 chr11:66035641 RAB1B -0.46 -5.63 -0.3 3.8e-8 Electroencephalogram traits; CRC cis rs2228479 0.850 rs17232910 chr16:89839766 G/C cg19635926 chr16:89946313 TCF25 0.62 5.73 0.3 2.3e-8 Skin colour saturation; CRC cis rs7666738 0.791 rs10033211 chr4:98995624 T/A cg05340658 chr4:99064831 C4orf37 0.61 9.54 0.47 3.44e-19 Colonoscopy-negative controls vs population controls; CRC cis rs7259376 0.846 rs5014503 chr19:22568340 A/T cg02657401 chr19:22469223 NA -0.33 -7.24 -0.37 3.3e-12 Menopause (age at onset); CRC cis rs3733585 0.699 rs6449178 chr4:9968684 A/G cg00071950 chr4:10020882 SLC2A9 0.57 10.17 0.49 2.64e-21 Cleft plate (environmental tobacco smoke interaction); CRC cis rs12908161 1.000 rs62019469 chr15:85321220 T/C cg17507749 chr15:85114479 UBE2QP1 0.61 8.82 0.44 6.96e-17 Schizophrenia; CRC cis rs9837602 1.000 rs35521705 chr3:99716690 C/T cg07805332 chr3:99536008 MIR548G;C3orf26 -0.47 -6.24 -0.33 1.37e-9 Breast cancer; CRC cis rs2952156 0.920 rs2517953 chr17:37841211 G/C cg00129232 chr17:37814104 STARD3 -0.74 -13.22 -0.59 2.63e-32 Asthma; CRC trans rs6601327 0.602 rs7829463 chr8:9649691 C/G cg06636001 chr8:8085503 FLJ10661 -0.51 -7.54 -0.38 4.6e-13 Multiple myeloma (hyperdiploidy); CRC cis rs1799949 1.000 rs8176212 chr17:41226601 G/C cg19454999 chr17:41278357 BRCA1;NBR2 0.55 8.61 0.43 3.01e-16 Menopause (age at onset); CRC cis rs2976388 0.967 rs2976395 chr8:143763750 G/A cg04969067 chr8:143858791 LYNX1 -0.35 -5.92 -0.31 8.2e-9 Urinary tract infection frequency; CRC cis rs270601 0.739 rs3900945 chr5:131592870 T/C cg01305625 chr5:131593812 PDLIM4 0.33 5.93 0.31 7.67e-9 Acylcarnitine levels; CRC cis rs28386778 0.865 rs2727276 chr17:61929709 G/A cg23090583 chr17:61904693 PSMC5;FTSJ3 1.03 19.93 0.74 1.63e-58 Prudent dietary pattern; CRC cis rs6866344 0.570 rs4266420 chr5:178137161 C/G cg03877680 chr5:178157825 ZNF354A 0.78 11.2 0.53 7.25e-25 Neutrophil percentage of white cells; CRC cis rs751728 1.000 rs2296748 chr6:33745071 C/T cg25922239 chr6:33757077 LEMD2 0.62 9.67 0.47 1.28e-19 Crohn's disease; CRC cis rs11098499 0.863 rs34308924 chr4:120481431 T/C cg09307838 chr4:120376055 NA 0.67 9.99 0.48 1.1e-20 Corneal astigmatism; CRC cis rs4319547 0.656 rs1553179 chr12:122831073 A/G cg05707623 chr12:122985044 ZCCHC8 -0.7 -8.62 -0.43 2.84e-16 Body mass index; CRC cis rs6662572 0.737 rs4557909 chr1:46316949 T/C cg08644498 chr1:46502608 NA -0.45 -7.07 -0.36 9.42e-12 Blood protein levels; CRC cis rs4268898 0.795 rs12470303 chr2:24619883 C/T cg06627628 chr2:24431161 ITSN2 -0.43 -6.42 -0.33 4.72e-10 Asthma; CRC cis rs898097 0.812 rs56274787 chr17:80862682 C/T cg16060761 chr17:80687452 NA 0.43 6.28 0.33 1.05e-9 Breast cancer; CRC cis rs8008758 0.963 rs10132271 chr14:101688874 C/T cg26224664 chr14:101693935 NA -0.42 -6.5 -0.34 2.99e-10 Body mass index (alcohol intake interaction); CRC cis rs9322193 0.962 rs3805749 chr6:150093682 C/T cg04369109 chr6:150039330 LATS1 -0.45 -5.91 -0.31 8.44e-9 Lung cancer; CRC cis rs853679 0.517 rs9393887 chr6:28059020 G/A cg12273811 chr6:28175739 NA 0.72 9.33 0.46 1.66e-18 Depression; CRC cis rs6912958 0.712 rs2246113 chr6:88410050 C/T cg08069147 chr6:88032118 GJB7;C6orf162 -0.54 -7.97 -0.4 2.57e-14 Monocyte percentage of white cells; CRC cis rs3820068 0.581 rs68052904 chr1:15916714 T/C cg27534772 chr1:16042836 PLEKHM2 0.55 10.41 0.5 3.87e-22 Systolic blood pressure; CRC cis rs7927771 1.000 rs12787330 chr11:47812311 C/T cg05585544 chr11:47624801 NA -0.61 -10.84 -0.51 1.25e-23 Subjective well-being; CRC cis rs11971779 0.616 rs6467836 chr7:139023517 C/G cg23387468 chr7:139079360 LUC7L2 0.4 7.04 0.36 1.16e-11 Diisocyanate-induced asthma; CRC cis rs10751667 0.643 rs10794343 chr11:925493 C/T cg06064525 chr11:970664 AP2A2 -0.32 -6.48 -0.34 3.25e-10 Alzheimer's disease (late onset); CRC cis rs2576037 0.526 rs4890707 chr18:44497724 C/G cg23996704 chr18:44553084 KATNAL2 -0.37 -7.53 -0.38 5.06e-13 Personality dimensions; CRC cis rs60871478 1.000 rs62432253 chr7:802928 A/G cg13844804 chr7:814759 HEATR2 0.7 8.25 0.41 3.79e-15 Cerebrospinal P-tau181p levels; CRC cis rs2075671 0.857 rs11772849 chr7:100308412 G/A cg00334542 chr7:100209784 MOSPD3 -0.52 -6.69 -0.35 9.79e-11 Other erythrocyte phenotypes; CRC cis rs2204008 0.744 rs11181635 chr12:38378420 C/T cg26384229 chr12:38710491 ALG10B 0.68 9.22 0.45 3.74e-18 Bladder cancer; CRC cis rs12711979 0.509 rs10195596 chr2:3824222 T/G cg17052675 chr2:3827356 NA -0.86 -21.11 -0.76 3.77e-63 Itch intensity from mosquito bite adjusted by bite size; CRC cis rs3751196 0.708 rs74600793 chr12:104183718 T/C cg02344784 chr12:104178138 NT5DC3 0.7 7.16 0.37 5.23e-12 Sense of smell; CRC cis rs7927771 0.524 rs10838746 chr11:47706291 A/G cg20307385 chr11:47447363 PSMC3 0.46 6.7 0.35 8.98e-11 Subjective well-being; CRC cis rs4665809 0.652 rs10779956 chr2:26405985 A/G cg26119090 chr2:26468346 HADHA;HADHB -1.02 -14.18 -0.62 5.79e-36 Gut microbiome composition (summer); CRC cis rs4713118 0.699 rs573179 chr6:27849676 C/A cg21251018 chr6:28226885 NKAPL 0.47 6.48 0.34 3.39e-10 Parkinson's disease; CRC trans rs17685 0.784 rs1613890 chr7:75735037 T/C cg19862616 chr7:65841803 NCRNA00174 0.99 18.51 0.71 6.2e-53 Coffee consumption;Coffee consumption (cups per day); CRC cis rs10791097 0.765 rs7943757 chr11:130716157 C/T cg12179176 chr11:130786555 SNX19 0.5 7.55 0.38 4.38e-13 Autism spectrum disorder or schizophrenia;Schizophrenia; CRC cis rs7727544 0.904 rs6897575 chr5:131604535 C/T cg02033258 chr5:131593261 PDLIM4 0.35 6.8 0.35 5.03e-11 Blood metabolite levels; CRC cis rs4819052 0.851 rs8134392 chr21:46663790 A/G cg02159808 chr21:46707872 POFUT2;LOC642852 -0.51 -6.67 -0.35 1.07e-10 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs7085104 0.632 rs7097872 chr10:104606636 C/T cg04362960 chr10:104952993 NT5C2 0.6 8.66 0.43 2.1e-16 Immature fraction of reticulocytes;Schizophrenia; CRC cis rs898097 1.000 rs898098 chr17:80904564 G/A cg03160526 chr17:80928410 B3GNTL1 0.46 7.06 0.36 1.01e-11 Breast cancer; CRC cis rs7584330 0.697 rs60278044 chr2:238357118 A/G cg11271282 chr2:238384023 NA 0.44 5.6 0.3 4.52e-8 Prostate cancer; CRC cis rs10193935 0.901 rs62142599 chr2:42548935 G/A cg27598129 chr2:42591480 NA -0.55 -6.61 -0.34 1.51e-10 Colonoscopy-negative controls vs population controls; CRC cis rs4132509 0.793 rs10927047 chr1:243803677 A/T cg21452805 chr1:244014465 NA 0.61 6.59 0.34 1.76e-10 RR interval (heart rate); CRC cis rs4700695 0.668 rs253212 chr5:65497553 C/T cg21114390 chr5:65439923 SFRS12 -0.59 -7.85 -0.4 5.87e-14 Facial morphology (factor 19); CRC cis rs17401966 0.964 rs2027331 chr1:10276718 C/T cg19773385 chr1:10388646 KIF1B -0.55 -7.35 -0.38 1.53e-12 Hepatocellular carcinoma; CRC cis rs62103177 0.810 rs62096746 chr18:77619556 T/A cg00383167 chr18:77616694 NA 0.54 6.02 0.31 4.69e-9 Opioid sensitivity; CRC cis rs4969178 0.645 rs4490057 chr17:76375095 C/T cg02319466 chr17:76381040 PGS1 -0.39 -6.12 -0.32 2.66e-9 HDL cholesterol levels; CRC cis rs5769765 0.862 rs9616384 chr22:50313082 C/T cg22709217 chr22:50311962 ALG12;CRELD2 -1.12 -18.26 -0.71 6.49e-52 Schizophrenia; CRC cis rs7923609 0.902 rs10733793 chr10:65323809 T/G cg08743896 chr10:65200160 JMJD1C -0.41 -5.81 -0.3 1.51e-8 Educational attainment;Liver enzyme levels (alkaline phosphatase); CRC cis rs73200209 0.703 rs17427025 chr12:116677033 C/G cg01776926 chr12:116560359 MED13L -0.57 -6.83 -0.35 4.16e-11 Total body bone mineral density; CRC cis rs9326248 0.648 rs11216257 chr11:116932561 C/T cg26566898 chr11:117069891 TAGLN 0.38 6.86 0.35 3.51e-11 Blood protein levels; CRC cis rs12451471 0.529 rs2278620 chr17:78083565 G/A cg18972013 chr17:78078605 GAA -0.41 -5.92 -0.31 8.23e-9 Plateletcrit;Mean corpuscular hemoglobin concentration; CRC cis rs13108904 0.967 rs11247987 chr4:1294532 G/A cg21620606 chr4:1342894 KIAA1530 0.34 5.67 0.3 3.06e-8 Obesity-related traits; CRC trans rs951252 0.504 rs11734405 chr4:146081096 C/T cg16015499 chr1:159888603 TAGLN2 -0.52 -6.88 -0.35 3.09e-11 Hip circumference; CRC cis rs4713118 0.699 rs573179 chr6:27849676 C/A cg23161317 chr6:28129485 ZNF389 0.46 5.91 0.31 8.7e-9 Parkinson's disease; CRC cis rs6076065 0.894 rs2243448 chr20:23378345 G/A cg11657817 chr20:23433608 CST11 0.55 9.29 0.46 2.2e-18 Facial morphology (factor 15, philtrum width); CRC trans rs8002861 0.641 rs6561148 chr13:44426269 C/T cg12856521 chr11:46389249 DGKZ 0.45 7.33 0.37 1.83e-12 Leprosy; CRC cis rs10751667 0.666 rs7483273 chr11:951127 T/C cg06064525 chr11:970664 AP2A2 -0.29 -5.89 -0.31 9.34e-9 Alzheimer's disease (late onset); CRC cis rs7662987 0.517 rs2602866 chr4:100034997 A/G cg12011299 chr4:100065546 ADH4 0.49 9.26 0.45 2.63e-18 Smoking initiation; CRC cis rs875971 1.000 rs1183245 chr7:65541185 C/T cg00343986 chr7:65444356 GUSB -0.47 -6.94 -0.36 2.05e-11 Aortic root size; CRC cis rs7618915 0.501 rs11714030 chr3:52765882 C/T cg18099408 chr3:52552593 STAB1 -0.46 -7.92 -0.4 3.81e-14 Bipolar disorder; CRC cis rs10256972 0.568 rs1133043 chr7:1133305 C/G cg16145915 chr7:1198662 ZFAND2A -0.4 -7.73 -0.39 1.28e-13 Longevity;Endometriosis; CRC cis rs7044106 0.762 rs10760110 chr9:123412563 A/G cg09586646 chr9:123605570 PSMD5;LOC253039 -0.59 -8.4 -0.42 1.38e-15 Hip circumference adjusted for BMI; CRC cis rs7208859 0.573 rs4055105 chr17:29102550 A/G cg13385521 chr17:29058706 SUZ12P 0.73 8.39 0.42 1.49e-15 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs4689592 0.619 rs2359011 chr4:7066052 T/G cg06697600 chr4:7070879 GRPEL1 -0.5 -7.34 -0.37 1.72e-12 Monocyte percentage of white cells; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg00633736 chr17:15164050 PMP22 0.4 6.48 0.34 3.3e-10 Liver disease severity in Alagille syndrome; CRC cis rs1395 0.778 rs1978881 chr2:27400850 C/A cg14242246 chr2:27434262 C2orf28;SLC5A6 0.41 7.6 0.39 3.17e-13 Blood metabolite levels; CRC cis rs11233250 0.502 rs11233281 chr11:82414527 C/G cg17391194 chr11:82401662 NA -0.39 -6.08 -0.32 3.33e-9 Glioblastoma;Glioma; CRC cis rs9486719 0.947 rs12213375 chr6:96902134 A/G cg06623918 chr6:96969491 KIAA0776 -0.8 -9.33 -0.46 1.57e-18 Migraine;Coronary artery disease; CRC cis rs6461049 0.800 rs2398706 chr7:2156338 A/T cg02951883 chr7:2050386 MAD1L1 -0.61 -9.79 -0.47 5.01e-20 Schizophrenia; CRC cis rs847649 0.732 rs6465876 chr7:102497569 G/T cg18108683 chr7:102477205 FBXL13 -0.62 -10.63 -0.51 6.86e-23 Morning vs. evening chronotype; CRC cis rs8180040 0.620 rs56217494 chr3:47048452 T/G cg10298567 chr3:47292165 KIF9 0.39 6.09 0.32 3.21e-9 Colorectal cancer; CRC cis rs7772486 0.875 rs1331644 chr6:146398660 T/C cg23711669 chr6:146136114 FBXO30 0.65 11.28 0.53 3.52e-25 Lobe attachment (rater-scored or self-reported); CRC cis rs8072100 0.764 rs4794371 chr17:45627693 G/C cg25173405 chr17:45401733 C17orf57 0.44 6.78 0.35 5.44e-11 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs6860806 0.531 rs272887 chr5:131665713 A/G cg11843238 chr5:131593191 PDLIM4 0.42 7.13 0.37 6.22e-12 Breast cancer; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg25371088 chr1:156710915 MRPL24 0.43 6.14 0.32 2.32e-9 Intelligence (multi-trait analysis); CRC cis rs524281 0.773 rs7925123 chr11:65993213 G/C cg16950941 chr11:66035639 RAB1B -0.7 -8.04 -0.41 1.67e-14 Electroencephalogram traits; CRC cis rs4862750 0.872 rs56389997 chr4:187894796 A/C cg10295955 chr4:187884368 NA -1.07 -28.27 -0.84 4.63e-90 Lobe attachment (rater-scored or self-reported); CRC cis rs78456975 0.689 rs13391992 chr2:1542153 G/A cg26248373 chr2:1572462 NA -0.62 -7.08 -0.36 9.04e-12 Placebo response in major depressive disorder (% change in symptom score); CRC cis rs7666738 0.687 rs6839454 chr4:99073914 T/C cg17366294 chr4:99064904 C4orf37 0.4 6.54 0.34 2.42e-10 Colonoscopy-negative controls vs population controls; CRC cis rs2549003 1.000 rs2549003 chr5:131829297 A/G cg00255919 chr5:131827918 IRF1 0.61 12.43 0.57 2.32e-29 Asthma (sex interaction); CRC cis rs1799949 0.501 rs2343819 chr17:41409653 T/G cg23758822 chr17:41437982 NA 0.79 13.4 0.59 5.5e-33 Menopause (age at onset); CRC cis rs883565 0.655 rs9837975 chr3:39064293 T/C cg01426195 chr3:39028469 NA -0.47 -7.84 -0.4 6.17e-14 Handedness; CRC cis rs9768139 0.634 rs56389048 chr7:158121368 T/A cg24154853 chr7:158122151 PTPRN2 0.65 10.66 0.51 5.33e-23 Calcium levels; CRC cis rs7666738 0.712 rs34043080 chr4:99008748 G/C cg17366294 chr4:99064904 C4orf37 0.43 7.14 0.37 5.89e-12 Colonoscopy-negative controls vs population controls; CRC cis rs9660992 0.547 rs12143121 chr1:205199142 A/G cg21643547 chr1:205240462 TMCC2 -0.37 -6.04 -0.32 4.25e-9 Mean corpuscular volume;Mean platelet volume; CRC cis rs1005277 0.505 rs200937 chr10:38135772 T/C cg00409905 chr10:38381863 ZNF37A -0.63 -10.46 -0.5 2.79e-22 Extrinsic epigenetic age acceleration; CRC cis rs9660180 0.846 rs10907195 chr1:1713348 C/T cg13866156 chr1:1669148 SLC35E2 0.49 7.23 0.37 3.34e-12 Body mass index; CRC cis rs4423214 1.000 rs12791871 chr11:71164544 A/C cg05163923 chr11:71159392 DHCR7 0.67 9.51 0.46 4.2e-19 Vitamin D levels; CRC trans rs1941687 0.563 rs9947894 chr18:31328720 G/T cg27147174 chr7:100797783 AP1S1 0.36 6.08 0.32 3.24e-9 Subjective well-being (multi-trait analysis);Subjective well-being; CRC cis rs947211 1.000 rs1775151 chr1:205745684 C/T cg14893161 chr1:205819251 PM20D1 0.46 6.31 0.33 8.93e-10 Parkinson's disease; CRC cis rs1976403 0.659 rs10799699 chr1:21820961 C/T cg00786952 chr1:21763130 NA 0.49 8.4 0.42 1.33e-15 Liver enzyme levels (alkaline phosphatase); CRC cis rs290268 1.000 rs188313 chr9:93548302 C/T cg02608019 chr9:93564028 SYK 0.45 7.23 0.37 3.39e-12 Platelet count; CRC cis rs2737618 0.630 rs2821328 chr1:200082051 G/A cg21825944 chr1:200113062 NR5A2 -0.49 -7.26 -0.37 2.74e-12 Uric acid levels; CRC cis rs1670533 1.000 rs676561 chr4:1083112 C/T cg27284194 chr4:1044797 NA 0.49 6.24 0.33 1.37e-9 Recombination rate (females); CRC cis rs6694270 0.529 rs4076925 chr1:19113026 C/T cg19637330 chr1:19110922 NA 0.43 5.97 0.31 6.27e-9 Drug-induced liver injury (nitrofurantoin); CRC cis rs2562152 0.706 rs216598 chr16:108585 T/C cg02949481 chr16:131562 MPG 0.58 6.54 0.34 2.3e-10 Glioblastoma; CRC cis rs7568458 0.684 rs7593969 chr2:85809670 A/G cg02493740 chr2:85810744 VAMP5 0.54 8.15 0.41 7.84e-15 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); CRC trans rs17641971 0.899 rs818557 chr8:49984515 G/C cg18784943 chr17:79371681 NA 0.41 6.18 0.32 1.87e-9 Blood metabolite levels; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg00140910 chr6:131384370 EPB41L2 0.44 6.45 0.34 3.99e-10 Intelligence (multi-trait analysis); CRC cis rs853679 0.527 rs9468333 chr6:28271198 C/T cg06470822 chr6:28175283 NA 0.48 6.63 0.34 1.39e-10 Depression; CRC trans rs10242455 0.702 rs1045012 chr7:98984354 G/C cg09045935 chr12:6379348 NA 0.99 7.44 0.38 8.57e-13 Blood metabolite levels; CRC cis rs12477438 0.953 rs3851334 chr2:99794704 T/C cg26064155 chr2:99771622 LIPT1;TSGA10 -0.74 -9.06 -0.45 1.18e-17 Chronic sinus infection; CRC cis rs7945705 0.935 rs11042102 chr11:8882164 C/T cg14711859 chr11:8959438 ASCL3 -0.51 -8.28 -0.42 3.03e-15 Hemoglobin concentration; CRC cis rs17433780 0.897 rs12142922 chr1:89489915 A/G cg09516651 chr1:89888402 LOC400759 0.47 7.18 0.37 4.53e-12 Carotid intima media thickness; CRC cis rs9611565 0.694 rs79011 chr22:41866938 A/G cg03806693 chr22:41940476 POLR3H 1.04 14.56 0.63 2.01e-37 Vitiligo; CRC cis rs12325245 0.536 rs34676074 chr16:58549321 G/C cg19824325 chr16:58548873 SETD6 0.96 6.28 0.33 1.08e-9 Schizophrenia; CRC cis rs7811142 0.775 rs1636980 chr7:99938864 A/G cg21679810 chr7:100027352 MEPCE;ZCWPW1 -0.9 -11.92 -0.55 1.83e-27 Platelet count; CRC trans rs4853036 0.540 rs55941844 chr2:69999728 T/A cg14633329 chr9:139640053 LCN6 -0.38 -6.34 -0.33 7.43e-10 Colorectal or endometrial cancer; CRC cis rs4925386 1.000 rs1889201 chr20:60923075 C/T cg24112000 chr20:60950667 NA 0.5 8.64 0.43 2.48e-16 Colorectal cancer;Colorectal cancer (SNP x SNP interaction); CRC cis rs34864796 0.547 rs200476 chr6:27768348 A/T cg15845792 chr6:28175446 NA 0.51 5.93 0.31 7.51e-9 Lung function (FEV1);Lung function (FEV1/FVC);Lung function (FVC); CRC cis rs9457247 0.602 rs9457262 chr6:167473685 A/G cg07741184 chr6:167504864 NA 0.44 7.41 0.38 1.11e-12 Crohn's disease; CRC trans rs13046373 0.905 rs4816372 chr21:32077414 A/T cg15123149 chr5:14485252 TRIO -0.37 -6.18 -0.32 1.85e-9 HDL cholesterol; CRC cis rs1046896 0.503 rs12947062 chr17:80686370 A/G cg02711726 chr17:80685570 FN3KRP 0.59 9.33 0.46 1.55e-18 Glycated hemoglobin levels; CRC cis rs9527 0.641 rs4919684 chr10:104587024 A/G cg23093090 chr10:104574429 C10orf26 -0.41 -5.76 -0.3 1.94e-8 Arsenic metabolism; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg10815483 chr17:16394899 C17orf76 0.46 6.8 0.35 4.92e-11 Response to antipsychotic treatment; CRC cis rs9916302 0.851 rs9904919 chr17:37556431 G/C cg00129232 chr17:37814104 STARD3 0.55 8.18 0.41 6.45e-15 Glomerular filtration rate (creatinine); CRC cis rs7208859 0.623 rs11652533 chr17:29060601 A/C cg13385521 chr17:29058706 SUZ12P 0.7 7.87 0.4 5.18e-14 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs9549367 0.577 rs3024713 chr13:113813321 G/A cg18105134 chr13:113819100 PROZ -0.73 -9.41 -0.46 9.12e-19 Platelet distribution width; CRC trans rs11661542 0.967 rs11082043 chr18:20222985 C/G cg01231434 chr16:23607392 NDUFAB1 -0.44 -6.07 -0.32 3.62e-9 Intracranial aneurysm; CRC cis rs7659604 1.000 rs72678650 chr4:122666000 A/G cg19748678 chr4:122722346 EXOSC9 0.56 8.9 0.44 3.69e-17 Type 2 diabetes; CRC cis rs2280018 1.000 rs2280017 chr16:15151361 A/G cg27102117 chr16:15229624 NA -0.38 -6.68 -0.35 1.01e-10 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid);Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CRC trans rs9929218 0.817 rs8055912 chr16:68802068 C/T cg04657470 chr2:198365150 HSPE1;HSPD1 -0.83 -11.86 -0.55 2.96e-27 Colorectal cancer; CRC cis rs17711722 0.675 rs6947132 chr7:65273495 G/A cg18912574 chr7:65842487 NCRNA00174 -0.33 -5.62 -0.3 4.18e-8 Calcium levels; CRC cis rs4660306 0.961 rs4660864 chr1:45966582 C/T cg03123370 chr1:45965343 CCDC163P;MMACHC -0.59 -8.31 -0.42 2.6e-15 Homocysteine levels; CRC cis rs4731207 0.596 rs6466982 chr7:124656788 G/A cg23710748 chr7:124431027 NA -0.39 -6.25 -0.33 1.24e-9 Cutaneous malignant melanoma; CRC cis rs3859192 0.599 rs2302777 chr17:38179492 A/G cg17344932 chr17:38183730 MED24;SNORD124 0.88 18.11 0.71 2.38e-51 White blood cell count; CRC cis rs11628318 0.614 rs62007925 chr14:103128288 G/A cg12046867 chr14:103022105 NA 0.76 8.98 0.44 2.2e-17 Platelet count; CRC cis rs2302190 0.882 rs3744111 chr17:56607959 G/A cg25885038 chr17:56607967 SEPT4 -0.52 -7.86 -0.4 5.41e-14 Vitamin D levels; CRC cis rs7589728 1.000 rs7589728 chr2:88518440 G/A cg24977027 chr2:88469347 THNSL2 0.52 6.13 0.32 2.47e-9 Plasma clusterin levels; CRC cis rs10919791 0.501 rs12024418 chr1:199916164 T/C cg13229857 chr1:200006247 NR5A2 0.44 6.49 0.34 3.13e-10 Pancreatic cancer; CRC cis rs853679 0.723 rs1736904 chr6:28219270 G/A cg03623178 chr6:28175578 NA 0.77 9.26 0.45 2.74e-18 Depression; CRC cis rs6500602 0.627 rs709632 chr16:4587811 C/G cg08645402 chr16:4508243 NA -0.58 -9.48 -0.46 5.29e-19 Schizophrenia; CRC cis rs1059312 0.545 rs12303387 chr12:129276733 C/T cg09035930 chr12:129282057 SLC15A4 -0.46 -6.79 -0.35 5.37e-11 Systemic lupus erythematosus; CRC cis rs704795 0.775 rs4665975 chr2:27626017 A/T cg21248554 chr2:27665150 KRTCAP3 -0.32 -6.93 -0.36 2.25e-11 Menopause (age at onset); CRC cis rs758324 0.947 rs615305 chr5:131291856 A/G cg25547332 chr5:131281432 NA -0.38 -5.61 -0.3 4.32e-8 Alzheimer's disease in APOE e4- carriers; CRC cis rs13191362 0.935 rs73023493 chr6:162952769 G/A cg21926612 chr6:163149169 PACRG;PARK2 0.81 9.96 0.48 1.37e-20 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC trans rs7615952 0.688 rs12485622 chr3:125710739 T/C cg07211511 chr3:129823064 LOC729375 -0.77 -10.83 -0.51 1.37e-23 Blood pressure (smoking interaction); CRC cis rs17023223 0.553 rs11484962 chr1:119725186 G/A cg05756136 chr1:119680316 WARS2 -0.52 -7.14 -0.37 6e-12 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for BMI in active individuals; CRC cis rs3790645 1.000 rs3790645 chr1:26884864 G/A cg17456097 chr1:26900765 RPS6KA1 0.39 5.78 0.3 1.74e-8 Glucose homeostasis traits; CRC cis rs2836974 0.555 rs35909862 chr21:40621158 G/A cg22974920 chr21:40686053 BRWD1 -0.43 -5.9 -0.31 9.15e-9 Cognitive function; CRC cis rs6912958 0.781 rs13193380 chr6:88297057 G/T cg12350822 chr6:88032061 C6orf162;GJB7 -0.34 -6.37 -0.33 6.44e-10 Monocyte percentage of white cells; CRC cis rs2404602 0.583 rs12907668 chr15:76589767 A/T cg03037974 chr15:76606532 NA 0.83 16.68 0.68 1.06e-45 Blood metabolite levels; CRC cis rs2456568 0.802 rs10765640 chr11:93636462 C/T cg26875233 chr11:93583750 C11orf90 -0.32 -6.27 -0.33 1.14e-9 Response to serotonin reuptake inhibitors in major depressive disorder; CRC cis rs7772486 0.875 rs2748502 chr6:146298239 A/G cg23711669 chr6:146136114 FBXO30 0.61 10.19 0.49 2.26e-21 Lobe attachment (rater-scored or self-reported); CRC cis rs3768617 0.528 rs6686682 chr1:183080539 A/G ch.1.3577855R chr1:183094577 LAMC1 0.88 15.62 0.65 1.5e-41 Fuchs's corneal dystrophy; CRC cis rs2842992 0.662 rs2273826 chr6:160211421 A/G cg19482086 chr6:160211437 TCP1;MRPL18 0.84 13.56 0.6 1.38e-33 Age-related macular degeneration (geographic atrophy); CRC cis rs208520 0.909 rs62414636 chr6:67015723 T/G cg07460842 chr6:66804631 NA 0.84 9.91 0.48 1.91e-20 Exhaled nitric oxide output; CRC cis rs897984 0.806 rs8052245 chr16:30916430 C/G cg02466173 chr16:30829666 NA 0.64 9.64 0.47 1.5700000000000001e-19 Dementia with Lewy bodies; CRC trans rs916888 0.773 rs199448 chr17:44809001 A/G cg22968622 chr17:43663579 NA 1.45 19.89 0.74 2.22e-58 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs10971721 0.822 rs10971788 chr9:33915085 G/A cg13495928 chr9:33750294 PRSS3 0.57 6.22 0.32 1.52e-9 Body mass index; CRC cis rs9311676 0.656 rs56384862 chr3:58395863 A/G cg06643156 chr3:58380774 PXK 0.4 6.11 0.32 2.85e-9 Systemic lupus erythematosus; CRC cis rs875971 0.545 rs1638724 chr7:66040481 A/G cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.61 -7.93 -0.4 3.55e-14 Aortic root size; CRC cis rs1799949 0.896 rs8176098 chr17:41268206 A/C cg01879757 chr17:41196368 BRCA1 -0.43 -6.52 -0.34 2.68e-10 Menopause (age at onset); CRC cis rs10256972 0.552 rs7805591 chr7:1210745 A/G cg07092213 chr7:1199455 ZFAND2A -0.48 -6.97 -0.36 1.77e-11 Longevity;Endometriosis; CRC cis rs1005277 0.579 rs2472176 chr10:38382921 T/C cg17219203 chr10:38645113 HSD17B7P2 -0.41 -5.76 -0.3 1.89e-8 Extrinsic epigenetic age acceleration; CRC cis rs728616 0.614 rs57342950 chr10:82105081 G/A cg05935833 chr10:81318306 SFTPA2 -0.46 -6.14 -0.32 2.43e-9 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs3126085 0.935 rs877776 chr1:152178018 C/G cg09127314 chr1:152161683 NA 0.48 6.29 0.33 9.91e-10 Atopic dermatitis; CRC cis rs7772486 0.782 rs7747576 chr6:146277827 C/T cg23711669 chr6:146136114 FBXO30 -0.71 -12.4 -0.56 3.24e-29 Lobe attachment (rater-scored or self-reported); CRC cis rs7666738 0.830 rs35865860 chr4:98968822 C/T cg17366294 chr4:99064904 C4orf37 0.42 7.21 0.37 3.76e-12 Colonoscopy-negative controls vs population controls; CRC cis rs10888329 0.741 rs4328104 chr1:248373326 A/G cg00666640 chr1:248458726 OR2T12 0.43 6.77 0.35 5.91e-11 Autism spectrum disorder; CRC cis rs4308124 0.708 rs10179596 chr2:111970380 G/A cg04571233 chr2:111982156 NA -0.56 -8.19 -0.41 5.82e-15 Vitiligo; CRC cis rs7086627 0.515 rs7907969 chr10:82153005 T/A cg00277334 chr10:82204260 NA -0.48 -7.74 -0.39 1.23e-13 Post bronchodilator FEV1; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg09273779 chr9:35605990 TESK1 0.49 6.38 0.33 5.88e-10 Thyroid stimulating hormone; CRC cis rs6499255 0.951 rs7200935 chr16:69564497 T/C cg04110750 chr16:69646130 NFAT5 -0.52 -7.25 -0.37 2.97e-12 IgE levels; CRC trans rs2303319 0.504 rs56405014 chr2:162497603 C/T cg12500891 chr11:57225987 NA -0.68 -6.07 -0.32 3.55e-9 Cognitive function; CRC cis rs9611565 0.592 rs4822044 chr22:41979668 G/C cg06481639 chr22:41940642 POLR3H -0.56 -5.99 -0.31 5.41e-9 Vitiligo; CRC cis rs9467711 0.606 rs67509210 chr6:26354100 G/T cg16898833 chr6:26189333 HIST1H4D 0.75 6.46 0.34 3.82e-10 Autism spectrum disorder or schizophrenia; CRC trans rs7180079 0.844 rs11071791 chr15:64602270 C/A cg22857141 chr5:123707481 NA 0.48 6.1 0.32 2.89e-9 Monocyte count; CRC cis rs7020830 0.898 rs997318 chr9:37364094 C/T cg14294708 chr9:37120828 ZCCHC7 1.19 27.18 0.83 4.1e-86 Schizophrenia; CRC cis rs6963495 0.651 rs3892298 chr7:105152187 A/G cg13798780 chr7:105162888 PUS7 0.67 7.78 0.39 9.18e-14 Bipolar disorder (body mass index interaction); CRC cis rs1008375 0.872 rs6831115 chr4:17640463 A/G cg16339924 chr4:17578868 LAP3 0.59 7.93 0.4 3.47e-14 Parasitemia in Tripanosoma cruzi seropositivity; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg01604592 chr1:44679056 DMAP1 0.41 6.78 0.35 5.52e-11 Liver disease severity in Alagille syndrome; CRC cis rs7772486 0.902 rs2748500 chr6:146314852 C/A cg23711669 chr6:146136114 FBXO30 0.61 10.19 0.49 2.32e-21 Lobe attachment (rater-scored or self-reported); CRC cis rs875971 0.862 rs6971059 chr7:66067032 A/G cg12463550 chr7:65579703 CRCP -0.47 -6.38 -0.33 5.89e-10 Aortic root size; CRC cis rs9858542 0.953 rs11711485 chr3:49491983 G/T cg07274523 chr3:49395745 GPX1 0.48 6.41 0.33 5.06e-10 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs7666738 0.791 rs12233867 chr4:98950233 A/G cg17366294 chr4:99064904 C4orf37 0.43 7.34 0.38 1.69e-12 Colonoscopy-negative controls vs population controls; CRC cis rs9291683 0.546 rs4575994 chr4:9997979 G/A cg00071950 chr4:10020882 SLC2A9 0.56 9.92 0.48 1.85e-20 Bone mineral density; CRC cis rs763014 0.966 rs15564 chr16:677854 G/T cg00908189 chr16:619842 PIGQ 0.65 10.68 0.51 4.85e-23 Height; CRC cis rs6586163 0.527 rs12775501 chr10:90750909 C/T cg13456138 chr10:90753195 FAS 0.41 5.77 0.3 1.84e-8 Chronic lymphocytic leukemia; CRC cis rs2762353 0.526 rs12215823 chr6:25726074 G/C cg16482183 chr6:26056742 HIST1H1C 0.41 5.66 0.3 3.35e-8 Blood metabolite levels; CRC cis rs6912958 0.754 rs4587143 chr6:88292291 A/G cg08069147 chr6:88032118 GJB7;C6orf162 -0.58 -8.66 -0.43 2.16e-16 Monocyte percentage of white cells; CRC cis rs394563 0.559 rs7752555 chr6:149671116 A/G cg11245181 chr6:149772854 ZC3H12D 0.52 9.09 0.45 9.67e-18 Dupuytren's disease; CRC cis rs67311347 1.000 rs2371186 chr3:40488713 G/C cg24209194 chr3:40518798 ZNF619 0.42 6.03 0.32 4.34e-9 Renal cell carcinoma; CRC cis rs4665809 0.887 rs6546716 chr2:26263836 A/G cg25036284 chr2:26402008 FAM59B -0.46 -6.0 -0.31 5.15e-9 Gut microbiome composition (summer); CRC cis rs2346177 0.542 rs6757564 chr2:46702619 G/C cg02822958 chr2:46747628 ATP6V1E2 0.43 6.53 0.34 2.5e-10 HDL cholesterol; CRC cis rs7074356 0.569 rs17102596 chr10:82035173 T/C cg27171509 chr10:82033454 MAT1A -0.48 -8.56 -0.43 4.23e-16 Borderline personality disorder; CRC cis rs4664308 0.875 rs60908067 chr2:161004983 T/G cg03641300 chr2:160917029 PLA2R1 -0.74 -12.23 -0.56 1.3e-28 Idiopathic membranous nephropathy; CRC cis rs9393777 0.513 rs13215020 chr6:26656073 G/A cg12292205 chr6:26970375 C6orf41 -0.61 -6.99 -0.36 1.52e-11 Intelligence (multi-trait analysis); CRC cis rs6502050 0.835 rs35857672 chr17:80078303 G/A cg25804541 chr17:80189381 SLC16A3 0.32 6.12 0.32 2.72e-9 Life satisfaction; CRC cis rs4285028 0.580 rs2293611 chr3:121643163 G/C cg20356878 chr3:121714668 ILDR1 -0.47 -7.57 -0.39 3.67e-13 Multiple sclerosis; CRC trans rs1997103 0.834 rs10274457 chr7:55390199 G/A cg20935933 chr6:143382018 AIG1 0.5 6.47 0.34 3.65e-10 QRS interval (sulfonylurea treatment interaction); CRC cis rs6543140 0.964 rs10200081 chr2:103091556 T/C cg09003973 chr2:102972529 NA 0.41 5.84 0.31 1.26e-8 Blood protein levels; CRC cis rs992157 0.764 rs3731861 chr2:219191256 T/C cg00012203 chr2:219082015 ARPC2 -0.4 -5.63 -0.3 3.9e-8 Colorectal cancer; CRC cis rs736408 0.509 rs2590838 chr3:52622086 G/A cg18099408 chr3:52552593 STAB1 -0.55 -10.03 -0.48 8.07e-21 Bipolar disorder; CRC trans rs11098499 0.779 rs72918579 chr4:120333222 G/C cg25214090 chr10:38739885 LOC399744 0.66 10.3 0.49 9.52e-22 Corneal astigmatism; CRC cis rs2204008 0.805 rs11169513 chr12:37988640 G/A cg13010199 chr12:38710504 ALG10B 0.45 5.61 0.3 4.35e-8 Bladder cancer; CRC cis rs735539 1.000 rs6490606 chr13:21285096 C/G cg27499820 chr13:21296301 IL17D -0.36 -5.81 -0.31 1.45e-8 Dental caries; CRC trans rs3942852 0.910 rs11603850 chr11:48140900 G/A cg03929089 chr4:120376271 NA -0.54 -6.61 -0.34 1.56e-10 Acute lymphoblastic leukemia (childhood); CRC cis rs9900062 1.000 rs9900062 chr17:62739574 G/A cg02097616 chr17:62675921 NA 0.48 5.85 0.31 1.2e-8 QT interval; CRC cis rs62408225 0.962 rs2325292 chr6:90986749 T/C cg06866423 chr6:90926672 BACH2 0.48 7.87 0.4 5.02e-14 Eosinophil counts;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC cis rs11039100 0.527 rs10769249 chr11:5839326 C/T cg03895540 chr11:5841482 OR52N2 -0.31 -5.68 -0.3 2.9e-8 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs116095464 0.558 rs7736600 chr5:231337 A/C cg22496380 chr5:211416 CCDC127 -0.86 -9.9 -0.48 2.13e-20 Breast cancer; CRC cis rs2204008 0.805 rs3863360 chr12:37966432 C/T cg13010199 chr12:38710504 ALG10B 0.46 6.13 0.32 2.46e-9 Bladder cancer; CRC cis rs6714710 0.580 rs1838797 chr2:98454572 G/C cg26665480 chr2:98280029 ACTR1B 0.52 7.18 0.37 4.53e-12 Posterior cortical atrophy and Alzheimer's disease; CRC trans rs2303319 0.504 rs56371522 chr2:162491109 G/A cg07195197 chr16:1662150 IFT140 -0.7 -5.98 -0.31 5.91e-9 Cognitive function; CRC cis rs9914988 0.832 rs34267753 chr17:27157586 T/C cg12682573 chr17:27188876 MIR451;MIR144 0.57 7.99 0.4 2.37e-14 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC trans rs12478296 0.901 rs59477854 chr2:243015490 T/C cg18288967 chr1:45987694 PRDX1 0.62 6.85 0.35 3.65e-11 Obesity-related traits; CRC cis rs9487051 0.676 rs4406271 chr6:109598213 G/A cg01475377 chr6:109611718 NA -0.37 -6.58 -0.34 1.85e-10 Reticulocyte fraction of red cells; CRC cis rs11690935 0.595 rs788171 chr2:172921832 A/G cg13550731 chr2:172543902 DYNC1I2 0.62 9.26 0.45 2.66e-18 Schizophrenia; CRC cis rs6952808 0.689 rs11771625 chr7:2050401 C/T cg18279126 chr7:2041391 MAD1L1 0.41 6.02 0.32 4.56e-9 Bipolar disorder and schizophrenia; CRC cis rs2737618 0.674 rs2258280 chr1:200097648 G/A cg21825944 chr1:200113062 NR5A2 -0.51 -7.35 -0.38 1.57e-12 Uric acid levels; CRC cis rs6838801 0.823 rs13139112 chr4:77584089 G/A cg17476223 chr4:77663285 SHROOM3 0.41 5.75 0.3 1.99e-8 Cleft lip with or without cleft palate; CRC cis rs9398803 0.830 rs1337735 chr6:126771024 T/A cg19875578 chr6:126661172 C6orf173 0.43 5.87 0.31 1.08e-8 Male-pattern baldness; CRC cis rs875971 1.000 rs709597 chr7:65825983 A/G cg18876405 chr7:65276391 NA -0.53 -9.17 -0.45 5.32e-18 Aortic root size; CRC cis rs4665809 0.567 rs6711402 chr2:26430983 A/G cg22920501 chr2:26401640 FAM59B -0.84 -11.13 -0.52 1.21e-24 Gut microbiome composition (summer); CRC cis rs2842992 0.662 rs2273826 chr6:160211421 A/G cg11366901 chr6:160182831 ACAT2 0.73 10.92 0.52 6.54e-24 Age-related macular degeneration (geographic atrophy); CRC cis rs10504229 0.639 rs16921812 chr8:58106737 C/T cg02290350 chr8:58132656 NA -0.59 -8.02 -0.4 1.88e-14 Developmental language disorder (linguistic errors); CRC cis rs4253772 0.550 rs738444 chr22:46721088 C/T cg03482458 chr22:46692211 CN5H6.4;GTSE1 0.57 7.79 0.39 8.63e-14 LDL cholesterol;Cholesterol, total; CRC cis rs7666738 0.830 rs10001479 chr4:98918764 A/G cg17366294 chr4:99064904 C4orf37 -0.41 -6.61 -0.34 1.56e-10 Colonoscopy-negative controls vs population controls; CRC cis rs951366 1.000 rs951366 chr1:205685352 C/T cg07157834 chr1:205819609 PM20D1 0.44 6.26 0.33 1.19e-9 Menarche (age at onset); CRC cis rs1153858 1.000 rs1719247 chr15:45620985 C/T cg21132104 chr15:45694354 SPATA5L1 0.51 7.37 0.38 1.4e-12 Homoarginine levels; CRC trans rs11165623 0.602 rs11165667 chr1:97013509 A/C cg10631902 chr5:14652156 NA -0.36 -6.17 -0.32 2.05e-9 Hip circumference;Waist circumference; CRC cis rs875971 0.929 rs778692 chr7:65872449 A/G cg11764359 chr7:65958608 NA 0.61 9.95 0.48 1.41e-20 Aortic root size; CRC cis rs11758351 1.000 rs76722536 chr6:26192946 C/G cg01420254 chr6:26195488 NA 0.86 9.08 0.45 1.06e-17 Gout;Renal underexcretion gout; CRC trans rs2228479 0.681 rs2270461 chr16:89972345 C/T cg24644049 chr4:85504048 CDS1 -0.55 -6.11 -0.32 2.75e-9 Skin colour saturation; CRC cis rs10946940 0.930 rs12215012 chr6:27507494 C/G cg06470822 chr6:28175283 NA -0.5 -6.77 -0.35 5.88e-11 Systemic lupus erythematosus; CRC cis rs514406 0.698 rs576891 chr1:53364976 A/G cg08859206 chr1:53392774 SCP2 -0.6 -9.18 -0.45 4.78e-18 Monocyte count; CRC cis rs952623 0.501 rs12670003 chr7:39083653 G/A cg18850127 chr7:39170497 POU6F2 0.44 5.71 0.3 2.53e-8 Intelligence (multi-trait analysis); CRC cis rs12586317 0.547 rs10145723 chr14:35460954 G/A cg16230307 chr14:35515116 FAM177A1 0.85 10.08 0.49 5.15e-21 Psoriasis; CRC cis rs1881797 0.527 rs78398999 chr1:247686970 G/A cg18198730 chr1:247681584 NA 0.62 6.91 0.36 2.55e-11 Acute lymphoblastic leukemia (childhood); CRC cis rs748404 0.690 rs2924369 chr15:43777985 G/A cg02155558 chr15:43621948 ADAL;LCMT2 -0.5 -7.16 -0.37 5.39e-12 Lung cancer; CRC cis rs9916302 0.904 rs9894500 chr17:37515735 G/C cg00129232 chr17:37814104 STARD3 0.53 7.83 0.4 6.67e-14 Glomerular filtration rate (creatinine); CRC cis rs11645898 0.748 rs11641424 chr16:72066879 C/T cg14768367 chr16:72042858 DHODH -0.74 -7.66 -0.39 2.13e-13 Blood protein levels; CRC cis rs3806843 0.932 rs2563257 chr5:140140529 A/G cg16607685 chr5:140181889 PCDHA2;PCDHA1;PCDHA3 0.26 5.99 0.31 5.59e-9 Depressive symptoms (multi-trait analysis); CRC cis rs2857891 0.909 rs56372435 chr11:6938658 T/C cg22096450 chr11:6947773 ZNF215 0.58 6.01 0.31 4.99e-9 Response to cytadine analogues (cytosine arabinoside); CRC cis rs1005277 0.557 rs1854563 chr10:38434961 G/A cg25517755 chr10:38738941 LOC399744 -0.42 -6.1 -0.32 3.03e-9 Extrinsic epigenetic age acceleration; CRC cis rs2625529 0.730 rs2957737 chr15:72265410 A/G cg16672083 chr15:72433130 SENP8 0.43 6.18 0.32 1.93e-9 Red blood cell count; CRC cis rs1534166 0.601 rs13324779 chr3:133510413 G/A cg01448562 chr3:133502909 NA 0.45 6.73 0.35 7.5e-11 Alcohol consumption (transferrin glycosylation); CRC cis rs4731207 0.596 rs6961441 chr7:124590871 G/A cg23710748 chr7:124431027 NA -0.38 -6.08 -0.32 3.35e-9 Cutaneous malignant melanoma; CRC cis rs11123170 0.543 rs35222158 chr2:113986629 C/T cg21550016 chr2:113992930 PAX8;LOC440839;LOC654433 0.52 6.13 0.32 2.52e-9 Renal function-related traits (BUN); CRC cis rs6500602 0.592 rs28789232 chr16:4447552 C/A cg08645402 chr16:4508243 NA 0.5 6.32 0.33 8.57e-10 Schizophrenia; CRC cis rs3820928 1.000 rs9288617 chr2:227762815 G/C cg11843606 chr2:227700838 RHBDD1 -0.4 -5.7 -0.3 2.67e-8 Pulmonary function; CRC trans rs10506458 1.000 rs17763435 chr12:63416511 A/G cg03429785 chr15:59498649 MYO1E;LDHAL6B 1.3 18.06 0.71 3.71e-51 Hemostatic factors and hematological phenotypes; CRC trans rs208520 0.955 rs12204033 chr6:67001525 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.8 9.78 0.47 5.36e-20 Exhaled nitric oxide output; CRC cis rs806215 0.723 rs1090682 chr7:127245159 T/C cg25922125 chr7:127225783 GCC1 0.58 6.37 0.33 6.52e-10 Type 2 diabetes; CRC cis rs6570726 0.846 rs446031 chr6:145885592 C/T cg13319975 chr6:146136371 FBXO30 -0.4 -5.99 -0.31 5.38e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs6582630 0.554 rs8189625 chr12:38401177 C/T cg13010199 chr12:38710504 ALG10B -0.4 -5.65 -0.3 3.44e-8 Drug-induced liver injury (flucloxacillin); CRC cis rs9916302 0.904 rs7216086 chr17:37709422 G/A cg00129232 chr17:37814104 STARD3 -0.57 -8.49 -0.42 7.31e-16 Glomerular filtration rate (creatinine); CRC cis rs7385804 0.761 rs1617640 chr7:100317298 C/A cg16850897 chr7:100343110 ZAN 0.44 6.62 0.34 1.45e-10 Iron status biomarkers;Mean corpuscular hemoglobin;Hematocrit;Iron status biomarkers (transferrin saturation);Red blood cell count;Iron status biomarkers (iron levels);Mean corpuscular volume;Hematological parameters; CRC cis rs3008870 1.000 rs4620509 chr1:67449941 A/G cg08660285 chr1:67390436 MIER1;WDR78 -1.04 -15.24 -0.64 4.66e-40 Lymphocyte percentage of white cells; CRC cis rs12497850 0.864 rs6779394 chr3:49157771 G/A cg20833759 chr3:49053208 WDR6;DALRD3 0.48 7.74 0.39 1.2e-13 Parkinson's disease; CRC cis rs7811142 0.830 rs73401450 chr7:99981859 G/C cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.16 16.77 0.68 4.92e-46 Platelet count; CRC cis rs514406 0.825 rs6695819 chr1:53223366 T/C cg24675658 chr1:53192096 ZYG11B 0.53 7.8 0.39 8.34e-14 Monocyte count; CRC cis rs600231 0.542 rs10896008 chr11:65245904 C/G cg17120908 chr11:65337727 SSSCA1 -0.69 -7.49 -0.38 6.51e-13 Bone mineral density; CRC cis rs6681460 0.549 rs1156618 chr1:67031564 T/C cg02459107 chr1:67143332 SGIP1 0.34 5.61 0.3 4.28e-8 Presence of antiphospholipid antibodies; CRC cis rs7224737 1.000 rs7219220 chr17:40294280 T/C cg20291162 chr17:40259547 DHX58 -0.55 -7.99 -0.4 2.31e-14 Fibrinogen levels; CRC cis rs4819052 0.851 rs1056101 chr21:46678702 C/G cg11663144 chr21:46675770 NA -0.77 -12.6 -0.57 5.52e-30 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs6502050 0.805 rs7406858 chr17:80080623 G/A cg25804541 chr17:80189381 SLC16A3 0.31 6.01 0.31 4.93e-9 Life satisfaction; CRC cis rs6810498 0.899 rs7661937 chr4:26062131 A/G cg12925881 chr4:26050407 NA -0.38 -6.58 -0.34 1.89e-10 Alcohol dependence; CRC cis rs977987 0.778 rs12929908 chr16:75462071 C/T cg03315344 chr16:75512273 CHST6 0.55 9.25 0.45 3.01e-18 Dupuytren's disease; CRC cis rs5498 0.803 rs62130687 chr19:10408995 G/A cg10604476 chr19:10403908 ICAM5 0.3 5.72 0.3 2.42e-8 Lymphocyte counts;Soluble ICAM-1;Blood protein levels; CRC cis rs4555082 0.834 rs2816651 chr14:105708470 A/G cg18132624 chr14:105716052 BTBD6;BRF1 -0.48 -8.04 -0.41 1.68e-14 Mean platelet volume;Platelet distribution width; CRC trans rs2727020 0.595 rs10839281 chr11:49483373 A/C cg15704280 chr7:45808275 SEPT13 -0.95 -18.05 -0.71 4.27e-51 Coronary artery disease; CRC cis rs10751667 0.666 rs6597960 chr11:977036 C/T ch.11.42038R chr11:967971 AP2A2 0.58 9.98 0.48 1.16e-20 Alzheimer's disease (late onset); CRC cis rs921968 0.565 rs7603709 chr2:219642601 C/T cg02176678 chr2:219576539 TTLL4 -0.41 -6.59 -0.34 1.8e-10 Mean corpuscular hemoglobin concentration; CRC cis rs875971 0.862 rs1612452 chr7:65573896 T/A cg18876405 chr7:65276391 NA -0.51 -8.49 -0.42 7.24e-16 Aortic root size; CRC cis rs9916302 0.904 rs8065963 chr17:37681332 C/T cg07936489 chr17:37558343 FBXL20 -0.82 -12.81 -0.58 9.31e-31 Glomerular filtration rate (creatinine); CRC cis rs17376456 0.877 rs13169675 chr5:93331284 A/G cg09848695 chr5:92956644 FAM172A;MIR2277 0.66 5.94 0.31 7.31e-9 Diabetic retinopathy; CRC cis rs9399135 0.967 rs1590975 chr6:135352088 C/T cg22676075 chr6:135203613 NA 0.38 5.89 0.31 9.75e-9 Red blood cell count; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg09564133 chr5:176738847 MXD3 0.47 6.69 0.35 9.33e-11 Response to antipsychotic treatment; CRC cis rs3820068 0.529 rs79570154 chr1:15990912 T/C cg27534772 chr1:16042836 PLEKHM2 0.56 10.56 0.5 1.18e-22 Systolic blood pressure; CRC cis rs769267 0.965 rs4808200 chr19:19554803 C/T cg17414380 chr19:19431394 KIAA0892;SF4 0.42 5.66 0.3 3.25e-8 Tonsillectomy; CRC cis rs9611565 0.559 rs6002408 chr22:41967870 C/T cg06634786 chr22:41940651 POLR3H -0.52 -5.96 -0.31 6.57e-9 Vitiligo; CRC cis rs1707322 1.000 rs1622208 chr1:46498375 A/G cg03146154 chr1:46216737 IPP -0.57 -7.84 -0.4 6.2e-14 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs11190604 1.000 rs4917901 chr10:102201773 A/C cg07570687 chr10:102243282 WNT8B 0.44 5.64 0.3 3.61e-8 Palmitoleic acid (16:1n-7) levels; CRC cis rs4332037 0.539 rs34809719 chr7:2028968 G/T cg02825527 chr7:2087843 MAD1L1 -0.49 -5.83 -0.31 1.34e-8 Bipolar disorder; CRC cis rs10256972 0.967 rs1881122 chr7:1040946 A/T cg07930192 chr7:1003750 NA 0.45 6.94 0.36 2.08e-11 Longevity;Endometriosis; CRC cis rs7762018 0.621 rs3823465 chr6:170068180 A/G cg15038512 chr6:170123185 PHF10 0.47 5.67 0.3 3.07e-8 Thiazide-induced adverse metabolic effects in hypertensive patients; CRC cis rs10242455 0.571 rs45527841 chr7:99310965 C/T cg18809830 chr7:99032528 PTCD1 -0.94 -7.27 -0.37 2.7e-12 Blood metabolite levels; CRC cis rs216303 0.841 rs2283333 chr12:6162852 T/C cg19878637 chr12:6148451 VWF -0.55 -6.61 -0.34 1.52e-10 Low vWF levels; CRC cis rs9916302 0.904 rs7216086 chr17:37709422 G/A cg03013999 chr17:37608204 MED1 0.47 7.28 0.37 2.46e-12 Glomerular filtration rate (creatinine); CRC cis rs9911578 1.000 rs9892062 chr17:56976981 G/A cg12560992 chr17:57184187 TRIM37 0.92 16.88 0.68 1.74e-46 Intelligence (multi-trait analysis); CRC cis rs2249694 1.000 rs8192781 chr10:135354251 T/G cg16964102 chr10:135390573 NA -0.37 -5.99 -0.31 5.38e-9 Obesity-related traits; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg00472393 chr6:97730957 C6orf167;MIR548H3 0.41 6.43 0.33 4.49e-10 Liver disease severity in Alagille syndrome; CRC cis rs4332037 0.722 rs55934553 chr7:1914059 T/C cg23422044 chr7:1970798 MAD1L1 -0.56 -7.29 -0.37 2.31e-12 Bipolar disorder; CRC cis rs6840360 0.642 rs2709833 chr4:152377622 A/G cg09659197 chr4:152720779 NA 0.33 6.46 0.34 3.69e-10 Intelligence (multi-trait analysis); CRC trans rs10502219 0.918 rs7947659 chr11:116419981 A/C cg20778451 chr5:178368205 ZNF454 -0.34 -6.03 -0.32 4.33e-9 Mitochondrial DNA levels; CRC cis rs7811142 0.830 rs7792525 chr7:99972122 A/G cg00814883 chr7:100076585 TSC22D4 -0.69 -8.57 -0.43 4.12e-16 Platelet count; CRC cis rs9303542 0.625 rs6504340 chr17:46617019 A/G cg04904318 chr17:46607828 HOXB1 0.44 6.15 0.32 2.22e-9 Ovarian cancer;Epithelial ovarian cancer; CRC cis rs2404602 0.669 rs1875884 chr15:76638161 C/T cg22467129 chr15:76604101 ETFA -0.46 -7.62 -0.39 2.73e-13 Blood metabolite levels; CRC cis rs473651 0.904 rs472247 chr2:239362573 G/A cg21699342 chr2:239360505 ASB1 0.54 9.76 0.47 6.28e-20 Multiple system atrophy; CRC cis rs17270561 0.887 rs12201170 chr6:25866247 A/G cg17691542 chr6:26056736 HIST1H1C 0.81 9.29 0.46 2.14e-18 Iron status biomarkers; CRC cis rs35146811 0.735 rs2272344 chr7:99786819 C/T cg00553149 chr7:99775558 STAG3;GPC2 0.24 5.9 0.31 8.81e-9 Coronary artery disease; CRC cis rs4665809 1.000 rs6720314 chr2:26334852 G/A cg26119090 chr2:26468346 HADHA;HADHB -0.65 -8.07 -0.41 1.37e-14 Gut microbiome composition (summer); CRC cis rs10504229 0.512 rs77289815 chr8:57995242 A/G cg21724239 chr8:58056113 NA 0.8 8.66 0.43 2.13e-16 Developmental language disorder (linguistic errors); CRC cis rs1153858 1.000 rs4395020 chr15:45652889 A/C cg21132104 chr15:45694354 SPATA5L1 0.57 8.42 0.42 1.15e-15 Homoarginine levels; CRC cis rs12681287 0.640 rs7007855 chr8:87429491 T/G cg27223183 chr8:87520930 FAM82B 0.52 7.41 0.38 1.09e-12 Caudate activity during reward; CRC trans rs3960554 0.808 rs2286829 chr7:75677739 G/A cg19862616 chr7:65841803 NCRNA00174 0.71 8.44 0.42 1.03e-15 Eotaxin levels; CRC cis rs4862750 1.000 rs4862750 chr4:187904043 C/T cg11301795 chr4:187892539 NA -0.89 -19.66 -0.73 1.85e-57 Lobe attachment (rater-scored or self-reported); CRC cis rs7412746 0.658 rs6657388 chr1:150748786 A/G cg18016565 chr1:150552671 MCL1 0.44 6.06 0.32 3.76e-9 Melanoma; CRC trans rs9747201 0.962 rs6502062 chr17:80086177 T/G cg07393940 chr7:158741817 NA -0.51 -7.4 -0.38 1.15e-12 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs2462686 1.000 rs1534150 chr7:45985290 T/C cg23193639 chr7:45961078 IGFBP3 -0.37 -5.69 -0.3 2.76e-8 Major depressive disorder; CRC cis rs116095464 0.558 rs62346508 chr5:203668 T/C cg22496380 chr5:211416 CCDC127 -0.93 -9.25 -0.45 2.86e-18 Breast cancer; CRC cis rs56283067 0.847 rs62435999 chr6:44695273 T/G cg18551225 chr6:44695536 NA -0.4 -5.8 -0.3 1.6e-8 Total body bone mineral density; CRC cis rs3741151 0.773 rs7925226 chr11:73137362 A/G cg17517138 chr11:73019481 ARHGEF17 0.92 7.7 0.39 1.63e-13 GIP levels in response to oral glucose tolerance test (120 minutes); CRC cis rs7113874 0.589 rs725502 chr11:8503743 A/G cg02811074 chr11:8615871 STK33 0.36 6.04 0.32 4.27e-9 Body mass index in physically active individuals;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs4819052 0.851 rs7275870 chr21:46671214 C/T cg02159808 chr21:46707872 POFUT2;LOC642852 0.49 6.54 0.34 2.4e-10 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs2842992 0.915 rs1322427 chr6:160075454 C/A cg11366901 chr6:160182831 ACAT2 0.85 11.3 0.53 2.96e-25 Age-related macular degeneration (geographic atrophy); CRC cis rs4481887 0.790 rs10888364 chr1:248488387 T/G cg00666640 chr1:248458726 OR2T12 0.46 7.93 0.4 3.55e-14 Common traits (Other); CRC cis rs7727544 0.735 rs274568 chr5:131713578 C/T cg24060327 chr5:131705240 SLC22A5 0.37 5.98 0.31 5.77e-9 Blood metabolite levels; CRC cis rs514406 0.929 rs1672908 chr1:53340885 A/G cg27535305 chr1:53392650 SCP2 -0.36 -6.46 -0.34 3.78e-10 Monocyte count; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg14218504 chr3:133380807 TOPBP1 0.47 6.4 0.33 5.48e-10 Anxiety disorder; CRC cis rs7746199 0.736 rs17693963 chr6:27710165 A/C cg26958806 chr6:27640298 NA 0.99 6.89 0.35 2.89e-11 Gait speed in old age;Autism spectrum disorder or schizophrenia; CRC cis rs11690935 0.632 rs1607254 chr2:172626552 A/G cg13550731 chr2:172543902 DYNC1I2 0.66 9.76 0.47 6.46e-20 Schizophrenia; CRC cis rs55726902 0.761 rs2544029 chr12:48194957 C/T cg14736327 chr12:48174669 SLC48A1 -0.41 -5.61 -0.3 4.35e-8 Allergic disease (asthma, hay fever or eczema); CRC cis rs4713118 0.513 rs149972 chr6:27983227 C/T cg23161317 chr6:28129485 ZNF389 0.45 6.38 0.33 5.99e-10 Parkinson's disease; CRC cis rs4423214 1.000 rs11606631 chr11:71164121 C/A cg05163923 chr11:71159392 DHCR7 0.66 9.43 0.46 7.42e-19 Vitamin D levels; CRC cis rs1865760 0.927 rs6915834 chr6:25935427 A/C cg16482183 chr6:26056742 HIST1H1C 0.54 7.44 0.38 9.04e-13 Height; CRC cis rs10782582 0.593 rs77733234 chr1:76101655 A/T cg10523679 chr1:76189770 ACADM -0.41 -5.83 -0.31 1.3e-8 Daytime sleep phenotypes; CRC cis rs60871478 0.635 rs4311567 chr7:792295 T/C cg13798912 chr7:905769 UNC84A 0.53 5.96 0.31 6.63e-9 Cerebrospinal P-tau181p levels; CRC cis rs1552244 0.882 rs6796419 chr3:10040812 G/A cg02579736 chr3:10068473 FANCD2;CIDECP 0.86 11.45 0.53 8.88e-26 Alzheimer's disease; CRC cis rs13108904 0.934 rs13124383 chr4:1299986 C/T cg00684032 chr4:1343700 KIAA1530 0.44 6.34 0.33 7.63e-10 Obesity-related traits; CRC cis rs7786808 0.579 rs4045391 chr7:158181826 T/C cg15440763 chr7:158190612 PTPRN2 0.53 8.63 0.43 2.66e-16 Obesity-related traits; CRC cis rs13118159 0.836 rs12647145 chr4:1338618 C/A cg19318889 chr4:1322082 MAEA 0.41 6.2 0.32 1.66e-9 Longevity; CRC cis rs9875589 0.509 rs4047237 chr3:14012861 T/C cg14375111 chr3:14165186 TMEM43;CHCHD4 0.41 5.95 0.31 6.74e-9 Ovarian reserve; CRC cis rs1799949 0.896 rs35908185 chr17:41255111 A/T cg05368731 chr17:41323189 NBR1 0.7 10.61 0.5 8.43e-23 Menopause (age at onset); CRC cis rs9648428 0.515 rs17172276 chr7:36202416 A/G cg14708893 chr7:36124863 NA -0.41 -6.1 -0.32 3.03e-9 Obesity-related traits; CRC cis rs11098499 0.954 rs34858317 chr4:120387110 A/C cg09307838 chr4:120376055 NA 0.71 10.92 0.52 6.75e-24 Corneal astigmatism; CRC trans rs2321882 0.794 rs55800294 chr13:59468828 A/G cg04268950 chr11:130298854 ADAMTS8 -0.45 -5.99 -0.31 5.64e-9 Body mass index; CRC cis rs6500395 1.000 rs3826174 chr16:48591012 T/C cg04672837 chr16:48644449 N4BP1 0.44 6.5 0.34 2.95e-10 Response to tocilizumab in rheumatoid arthritis; CRC cis rs2274273 0.588 rs9919923 chr14:55813899 A/G cg10130446 chr14:55658398 DLGAP5 -0.42 -5.82 -0.31 1.4e-8 Protein biomarker; CRC cis rs9682041 0.800 rs7643085 chr3:170070371 A/G cg11886554 chr3:170076028 SKIL 0.72 7.76 0.39 1.08e-13 Glomerular filtration rate in non diabetics (creatinine);Glomerular filtration rate (creatinine); CRC cis rs9928842 0.771 rs4888363 chr16:75277344 A/T cg09066997 chr16:75300724 BCAR1 0.68 7.18 0.37 4.66e-12 Alcoholic chronic pancreatitis; CRC cis rs4148883 0.545 rs17595102 chr4:99986316 C/G cg12011299 chr4:100065546 ADH4 0.53 11.2 0.53 6.74e-25 Alcohol dependence; CRC cis rs698833 0.501 rs10194161 chr2:44507213 A/G cg04920474 chr2:44395004 PPM1B -0.44 -6.8 -0.35 4.87e-11 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; CRC cis rs45509595 0.841 rs200485 chr6:27775697 G/C cg19041857 chr6:27730383 NA -0.73 -7.06 -0.36 9.84e-12 Breast cancer; CRC cis rs208520 0.526 rs9294682 chr6:66795159 G/A cg07460842 chr6:66804631 NA -1.16 -24.69 -0.81 7.19e-77 Exhaled nitric oxide output; CRC trans rs10982213 0.830 rs2274163 chr9:117188714 C/T cg08267591 chr2:165693745 COBLL1 0.39 6.26 0.33 1.21e-9 Interleukin-6 levels; CRC cis rs732072 0.826 rs605952 chr11:65475111 A/G cg21033440 chr11:65409861 SIPA1 -0.67 -5.7 -0.3 2.7e-8 Inflammatory bowel disease; CRC cis rs6912958 0.703 rs9359748 chr6:88095500 C/T cg08069147 chr6:88032118 GJB7;C6orf162 0.72 11.51 0.54 5.66e-26 Monocyte percentage of white cells; CRC cis rs4731207 0.698 rs10252039 chr7:124539537 T/C cg23710748 chr7:124431027 NA -0.37 -5.86 -0.31 1.15e-8 Cutaneous malignant melanoma; CRC cis rs2050392 0.624 rs303449 chr10:30726845 G/A cg18806716 chr10:30721971 MAP3K8 -0.7 -10.18 -0.49 2.39e-21 Inflammatory bowel disease; CRC cis rs4481887 0.676 rs28684663 chr1:248548325 T/C cg26353448 chr1:248524236 OR2T4 -0.31 -6.18 -0.32 1.94e-9 Common traits (Other); CRC cis rs921968 0.542 rs588182 chr2:219412335 C/A cg02176678 chr2:219576539 TTLL4 0.54 8.62 0.43 2.96e-16 Mean corpuscular hemoglobin concentration; CRC cis rs35146811 0.735 rs1061230 chr7:99807265 G/A cg13334819 chr7:99746414 C7orf59 0.51 6.72 0.35 7.79e-11 Coronary artery disease; CRC cis rs7927592 0.956 rs12281742 chr11:68303629 C/T cg01657329 chr11:68192670 LRP5 0.49 7.57 0.38 3.88e-13 Total body bone mineral density; CRC trans rs3942852 0.726 rs10742836 chr11:48175831 G/A cg03929089 chr4:120376271 NA -0.72 -9.05 -0.45 1.27e-17 Acute lymphoblastic leukemia (childhood); CRC cis rs6424115 1.000 rs2256179 chr1:24132305 A/G cg09473613 chr1:24152604 HMGCL -0.34 -5.93 -0.31 7.87e-9 Immature fraction of reticulocytes; CRC cis rs12760731 0.565 rs71628268 chr1:178151908 T/C cg00404053 chr1:178313656 RASAL2 1.12 11.36 0.53 1.89e-25 Obesity-related traits; CRC cis rs907683 0.584 rs1058284 chr2:220286142 G/A cg15015639 chr2:220282977 DES -0.4 -6.65 -0.34 1.2e-10 Resting heart rate; CRC cis rs2404602 0.532 rs744336 chr15:76674624 T/C cg00316803 chr15:76480434 C15orf27 -0.36 -6.23 -0.32 1.45e-9 Blood metabolite levels; CRC cis rs7587476 0.599 rs61073893 chr2:215744814 C/T cg04004882 chr2:215674386 BARD1 0.68 8.38 0.42 1.6e-15 Neuroblastoma; CRC cis rs6589219 0.954 rs3802842 chr11:111171709 C/A cg25129781 chr11:111156908 C11orf53 -0.31 -5.77 -0.3 1.82e-8 Colorectal cancer; CRC cis rs4731207 0.596 rs7799712 chr7:124649717 G/C cg23710748 chr7:124431027 NA -0.39 -6.25 -0.33 1.24e-9 Cutaneous malignant melanoma; CRC cis rs7707921 0.767 rs226199 chr5:81572464 G/C cg07807695 chr5:81608485 ATP6AP1L -0.49 -7.75 -0.39 1.17e-13 Breast cancer; CRC cis rs757110 0.866 rs5215 chr11:17408630 C/T cg15432903 chr11:17409602 KCNJ11 0.78 12.68 0.57 2.8e-30 Type 2 diabetes; CRC cis rs6062302 0.522 rs13043255 chr20:62218916 C/G cg06363034 chr20:62225388 GMEB2 -0.44 -6.77 -0.35 5.94e-11 Glioblastoma; CRC trans rs2303319 0.504 rs62188728 chr2:162335701 T/C cg18122310 chr12:50236657 BCDIN3D -0.72 -6.02 -0.31 4.69e-9 Cognitive function; CRC cis rs10256972 0.900 rs7812072 chr7:1053862 A/G cg03923535 chr7:1197113 ZFAND2A 0.42 5.71 0.3 2.5e-8 Longevity;Endometriosis; CRC cis rs7618915 0.547 rs34173654 chr3:52634605 T/C cg15147215 chr3:52552868 STAB1 -0.62 -10.22 -0.49 1.8e-21 Bipolar disorder; CRC trans rs9858542 1.000 rs13316695 chr3:49684917 C/G cg21665057 chr3:196295764 WDR53;FBXO45 -0.68 -8.9 -0.44 3.71e-17 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs853679 0.517 rs9393901 chr6:28136797 A/G cg02683197 chr6:28174875 NA 0.87 10.73 0.51 3.25e-23 Depression; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg14431266 chr11:67057003 ANKRD13D 0.51 6.67 0.35 1.06e-10 Thyroid stimulating hormone; CRC cis rs4332037 0.539 rs11764590 chr7:2032803 C/T cg24505167 chr7:1915268 MAD1L1 -0.45 -6.28 -0.33 1.09e-9 Bipolar disorder; CRC cis rs875971 0.545 rs7783889 chr7:65748353 T/A cg11764359 chr7:65958608 NA 0.46 5.95 0.31 6.92e-9 Aortic root size; CRC cis rs9291683 0.530 rs10939620 chr4:9946132 C/T cg11266682 chr4:10021025 SLC2A9 -0.5 -10.04 -0.48 7.5e-21 Bone mineral density; CRC cis rs992157 0.767 rs2014615 chr2:219171191 A/G cg13835894 chr2:219148914 PNKD;TMBIM1 0.32 6.16 0.32 2.16e-9 Colorectal cancer; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg15090714 chr17:60142985 MED13 0.45 7.32 0.37 1.93e-12 Liver disease severity in Alagille syndrome; CRC cis rs7584330 0.704 rs72620821 chr2:238362615 C/A cg11271282 chr2:238384023 NA 0.48 5.6 0.3 4.45e-8 Prostate cancer; CRC cis rs1322512 0.677 rs2695254 chr6:152926021 A/C cg03415253 chr6:152958462 SYNE1 -0.38 -5.92 -0.31 8.15e-9 Tonometry; CRC cis rs2839186 0.933 rs56955294 chr21:47708953 A/G cg09417038 chr21:47716443 C21orf57 -0.42 -6.93 -0.36 2.21e-11 Testicular germ cell tumor; CRC cis rs9916302 0.706 rs582176 chr17:37453999 T/C cg07936489 chr17:37558343 FBXL20 0.84 10.61 0.5 8.08e-23 Glomerular filtration rate (creatinine); CRC cis rs10911390 0.793 rs112313734 chr1:183605035 G/A cg11505048 chr1:183622726 RGL1;APOBEC4 0.75 6.51 0.34 2.73e-10 Systemic lupus erythematosus; CRC cis rs10924970 0.649 rs10925128 chr1:235378767 T/G cg09010748 chr1:235293032 TOMM20 -0.42 -5.87 -0.31 1.07e-8 Asthma; CRC cis rs8077889 0.871 rs8065043 chr17:41900984 G/A cg25876840 chr17:41920477 NA 0.51 7.63 0.39 2.62e-13 Triglycerides; CRC cis rs6500602 0.701 rs4786500 chr16:4525265 A/G cg06139259 chr16:4526053 HMOX2;NMRAL1 -0.54 -7.43 -0.38 9.17e-13 Schizophrenia; CRC cis rs9916302 0.680 rs2271308 chr17:37817482 T/C cg20243544 chr17:37824526 PNMT 0.52 8.26 0.41 3.53e-15 Glomerular filtration rate (creatinine); CRC cis rs2976388 1.000 rs2920298 chr8:143763043 A/G cg20041105 chr8:143859282 LYNX1 -0.32 -5.65 -0.3 3.45e-8 Urinary tract infection frequency; CRC cis rs912057 0.797 rs1294430 chr6:6744698 A/G cg06612196 chr6:6737390 NA 0.51 8.17 0.41 6.92e-15 Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction); CRC cis rs4713118 0.662 rs13218430 chr6:28029837 T/C cg03623178 chr6:28175578 NA 0.92 12.95 0.58 2.82e-31 Parkinson's disease; CRC cis rs6951245 1.000 rs77702926 chr7:1088838 G/A cg03188948 chr7:1209495 NA 0.64 6.46 0.34 3.71e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg00585572 chr22:41347381 RBX1 0.45 6.3 0.33 9.33e-10 Response to antipsychotic treatment; CRC cis rs10504229 0.683 rs17802743 chr8:58105897 C/T cg21724239 chr8:58056113 NA 0.78 9.79 0.47 5.01e-20 Developmental language disorder (linguistic errors); CRC trans rs34421088 0.560 rs2245357 chr8:11399484 A/T cg16141378 chr3:129829833 LOC729375 0.48 7.0 0.36 1.42e-11 Neuroticism; CRC trans rs10838798 0.504 rs1483123 chr11:48326773 G/A cg21153622 chr11:89784906 NA -0.48 -7.87 -0.4 5.17e-14 Height; CRC cis rs6662572 0.641 rs4660891 chr1:46319447 T/A cg08644498 chr1:46502608 NA -0.45 -7.07 -0.36 9.42e-12 Blood protein levels; CRC cis rs11627756 0.958 rs2146430 chr14:103071825 G/T cg12046867 chr14:103022105 NA -0.42 -5.77 -0.3 1.81e-8 Mean platelet volume; CRC cis rs644799 0.965 rs566877 chr11:95528045 G/A cg25478527 chr11:95522999 CEP57;FAM76B 0.51 7.69 0.39 1.68e-13 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs11758351 1.000 rs41266807 chr6:26199822 A/G cg01420254 chr6:26195488 NA 0.82 8.71 0.43 1.55e-16 Gout;Renal underexcretion gout; CRC cis rs7819412 0.775 rs2001329 chr8:10986859 C/T cg27411982 chr8:10470053 RP1L1 -0.38 -5.77 -0.3 1.8e-8 Triglycerides; CRC cis rs73206853 0.841 rs59698293 chr12:111054455 C/G cg12870014 chr12:110450643 ANKRD13A 0.77 7.23 0.37 3.44e-12 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC cis rs3733585 0.673 rs4697914 chr4:9952266 G/A cg11266682 chr4:10021025 SLC2A9 -0.47 -9.62 -0.47 1.76e-19 Cleft plate (environmental tobacco smoke interaction); CRC cis rs7552404 1.000 rs4949874 chr1:76161889 T/C cg22875332 chr1:76189707 ACADM 0.68 9.25 0.45 2.82e-18 Blood metabolite levels;Acylcarnitine levels; CRC cis rs4662945 0.688 rs10496679 chr2:130201113 G/A cg05903289 chr2:130345205 NA -0.3 -5.75 -0.3 2.02e-8 Response to cytidine analogues (gemcitabine); CRC cis rs2732480 0.500 rs2450991 chr12:48651621 A/G cg24011408 chr12:48396354 COL2A1 0.46 6.5 0.34 2.93e-10 Hemoglobin concentration;Red blood cell count;Hematocrit; CRC cis rs77633900 0.772 rs284897 chr15:76750722 T/C cg21673338 chr15:77095150 SCAPER -0.71 -6.48 -0.34 3.41e-10 Non-glioblastoma glioma;Glioma; CRC cis rs67311347 1.000 rs11714912 chr3:40494065 A/G cg24209194 chr3:40518798 ZNF619 -0.46 -7.08 -0.36 9.02e-12 Renal cell carcinoma; CRC cis rs10504229 0.683 rs11785258 chr8:58132893 A/G cg02725872 chr8:58115012 NA -0.64 -11.55 -0.54 3.85e-26 Developmental language disorder (linguistic errors); CRC cis rs11690935 0.959 rs76324055 chr2:172620150 T/A cg13550731 chr2:172543902 DYNC1I2 -1.07 -17.28 -0.69 4.62e-48 Schizophrenia; CRC cis rs9325144 0.541 rs7303395 chr12:38664124 C/T cg13010199 chr12:38710504 ALG10B -0.42 -6.17 -0.32 2.01e-9 Morning vs. evening chronotype; CRC cis rs9322193 0.847 rs12210605 chr6:150138403 A/G cg13206674 chr6:150067644 NUP43 0.67 9.25 0.45 2.84e-18 Lung cancer; CRC cis rs28386778 0.897 rs896064 chr17:61860932 C/T cg22520471 chr17:61851767 DDX42;CCDC47 0.75 11.69 0.54 1.26e-26 Prudent dietary pattern; CRC cis rs4319547 0.508 rs10846826 chr12:122894987 C/T cg05707623 chr12:122985044 ZCCHC8 -0.74 -9.21 -0.45 3.91e-18 Body mass index; CRC cis rs2380220 0.810 rs877096 chr6:95937046 A/G cg04719120 chr6:96025338 MANEA -0.55 -6.04 -0.32 4.15e-9 Behavioural disinhibition (generation interaction); CRC cis rs921968 0.643 rs3932856 chr2:219320207 C/A cg02176678 chr2:219576539 TTLL4 0.48 7.97 0.4 2.62e-14 Mean corpuscular hemoglobin concentration; CRC cis rs4713118 0.662 rs9468278 chr6:28028482 C/T cg21251018 chr6:28226885 NKAPL 0.46 6.53 0.34 2.56e-10 Parkinson's disease; CRC cis rs3820068 0.705 rs72643683 chr1:15824905 C/A cg27534772 chr1:16042836 PLEKHM2 0.41 6.95 0.36 1.99e-11 Systolic blood pressure; CRC cis rs7493 1.000 rs2299264 chr7:95046708 C/T cg20119798 chr7:94954144 PON1 -0.5 -6.52 -0.34 2.65e-10 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs6838801 0.523 rs344123 chr4:77638013 T/C cg17476223 chr4:77663285 SHROOM3 -0.44 -5.76 -0.3 1.93e-8 Cleft lip with or without cleft palate; CRC cis rs2041840 0.618 rs11124581 chr2:37576638 C/T cg25727520 chr2:37576821 QPCT -0.32 -5.72 -0.3 2.38e-8 Chronic lymphocytic leukemia; CRC cis rs7618915 0.547 rs11130314 chr3:52697082 T/C cg08222913 chr3:52553049 STAB1 -0.34 -6.23 -0.32 1.45e-9 Bipolar disorder; CRC cis rs8009147 1 rs8009147 chr14:104264662 A/G cg08213375 chr14:104286397 PPP1R13B 0.63 13.35 0.59 8.5e-33 Autism spectrum disorder or schizophrenia; CRC cis rs7487075 0.820 rs35497251 chr12:46692481 C/A cg22049899 chr12:47219821 SLC38A4 0.31 5.88 0.31 9.94e-9 Itch intensity from mosquito bite; CRC cis rs3540 0.553 rs8042861 chr15:90977333 G/T cg22089800 chr15:90895588 ZNF774 0.6 10.32 0.49 8.33e-22 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; CRC cis rs1003719 0.788 rs13050757 chr21:38465345 C/T cg10648535 chr21:38446584 PIGP;TTC3 0.52 7.41 0.38 1.07e-12 Eye color traits; CRC cis rs2153535 0.580 rs4960411 chr6:8438231 C/G cg07606381 chr6:8435919 SLC35B3 0.68 10.89 0.51 8.99e-24 Motion sickness; CRC cis rs2727020 0.796 rs7131672 chr11:49274421 A/C cg27395922 chr11:50257633 LOC441601 0.35 5.71 0.3 2.58e-8 Coronary artery disease; CRC trans rs10982213 0.830 rs2274163 chr9:117188714 C/T cg05800723 chr4:79103126 FRAS1 0.47 7.77 0.39 1e-13 Interleukin-6 levels; CRC cis rs2836974 0.966 rs7283420 chr21:40666865 T/C cg07074390 chr21:40555500 PSMG1 -0.46 -6.18 -0.32 1.87e-9 Cognitive function; CRC cis rs1005277 0.579 rs1780136 chr10:38501453 A/G cg17219203 chr10:38645113 HSD17B7P2 -0.41 -5.93 -0.31 7.61e-9 Extrinsic epigenetic age acceleration; CRC cis rs6582630 0.519 rs11495724 chr12:38337507 T/C cg26384229 chr12:38710491 ALG10B 0.68 9.68 0.47 1.15e-19 Drug-induced liver injury (flucloxacillin); CRC cis rs3087591 1.000 rs2854332 chr17:29712378 A/T cg24425628 chr17:29625626 OMG;NF1 -0.8 -14.83 -0.63 1.83e-38 Hip circumference; CRC cis rs898097 0.812 rs56274787 chr17:80862682 C/T cg19046167 chr17:80928561 B3GNTL1 -0.41 -6.35 -0.33 7.23e-10 Breast cancer; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg00619347 chr3:149688574 PFN2 0.37 6.26 0.33 1.2e-9 Liver disease severity in Alagille syndrome; CRC cis rs9322193 0.923 rs4421206 chr6:150004027 A/C cg00933542 chr6:150070202 PCMT1 0.31 6.39 0.33 5.83e-10 Lung cancer; CRC cis rs1983170 0.736 rs4484968 chr1:92012005 C/A cg21854759 chr1:92012499 NA 0.51 6.07 0.32 3.52e-9 Eosinophil percentage of white cells; CRC cis rs6860806 0.632 rs4330455 chr5:131586349 T/C cg11843238 chr5:131593191 PDLIM4 0.42 8.01 0.4 2.02e-14 Breast cancer; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg26500707 chr16:50100227 HEATR3 0.39 6.04 0.32 4.17e-9 Intelligence (multi-trait analysis); CRC cis rs8044995 0.563 rs56220628 chr16:68384837 G/A cg09835421 chr16:68378352 PRMT7 -0.7 -7.62 -0.39 2.69e-13 Schizophrenia; CRC cis rs11098499 0.863 rs3822190 chr4:120428098 G/A cg09307838 chr4:120376055 NA 0.68 10.2 0.49 2.03e-21 Corneal astigmatism; CRC cis rs9462846 0.919 rs9462844 chr6:42856502 T/G cg02353165 chr6:42928485 GNMT 0.45 6.24 0.33 1.38e-9 Blood protein levels; CRC cis rs172166 0.561 rs149971 chr6:27982152 G/A cg03623178 chr6:28175578 NA 0.65 9.79 0.47 5.02e-20 Cardiac Troponin-T levels; CRC cis rs1656402 1.000 rs1190437 chr2:233423796 C/G cg03852847 chr2:233439513 NA 0.45 7.71 0.39 1.54e-13 Non-small cell lung cancer (survival); CRC cis rs12410462 0.681 rs78978081 chr1:227571619 G/A cg04117972 chr1:227635322 NA 0.67 6.22 0.32 1.54e-9 Major depressive disorder; CRC cis rs4713118 0.540 rs469227 chr6:27970705 A/C cg21251018 chr6:28226885 NKAPL 0.45 6.89 0.36 2.83e-11 Parkinson's disease; CRC cis rs995000 0.931 rs2366636 chr1:63056670 G/A cg19896129 chr1:63156450 NA 0.42 6.53 0.34 2.48e-10 Triglyceride levels; CRC cis rs76419734 0.510 rs28450989 chr4:106630007 G/C cg24545054 chr4:106630052 GSTCD;INTS12 0.61 7.7 0.39 1.62e-13 Post bronchodilator FEV1; CRC cis rs1862618 0.853 rs832554 chr5:56115036 A/G cg12311346 chr5:56204834 C5orf35 -0.77 -10.09 -0.49 4.8e-21 Initial pursuit acceleration; CRC cis rs763014 0.966 rs15564 chr16:677854 G/T cg04497992 chr16:616212 NHLRC4 0.44 7.17 0.37 5.02e-12 Height; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg07595909 chr18:61089263 VPS4B 0.52 7.26 0.37 2.87e-12 Response to antipsychotic treatment; CRC cis rs1577917 1.000 rs6940458 chr6:86644992 A/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.51 -6.74 -0.35 7.09e-11 Response to antipsychotic treatment; CRC cis rs225245 0.817 rs1049379 chr17:33998802 G/C cg05299278 chr17:33885742 SLFN14 0.49 8.09 0.41 1.2e-14 Reticulocyte count;Reticulocyte fraction of red cells;High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells; CRC cis rs2592394 0.596 rs711829 chr2:177001292 C/A cg13092806 chr2:177043255 NA 0.5 5.73 0.3 2.31e-8 Magnesium levels;Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs736801 0.808 rs2248116 chr5:131804347 C/A cg21138405 chr5:131827807 IRF1 0.34 5.77 0.3 1.86e-8 Breast cancer;Mosquito bite size; CRC cis rs8141797 0.901 rs4306797 chr22:24453375 C/T cg20894457 chr22:24584366 SUSD2 -0.62 -7.39 -0.38 1.21e-12 Amyotrophic lateral sclerosis;Coronary artery disease; CRC cis rs17376456 0.825 rs6865441 chr5:93284746 G/A cg09848695 chr5:92956644 FAM172A;MIR2277 0.69 5.88 0.31 1.03e-8 Diabetic retinopathy; CRC cis rs61774743 0.681 rs10749805 chr1:41850182 C/T cg08144172 chr1:41849203 NA 0.33 5.68 0.3 2.92e-8 Intelligence (multi-trait analysis); CRC cis rs2274471 0.699 rs10758672 chr9:5116369 T/C cg03390472 chr9:5043263 JAK2 -0.53 -6.32 -0.33 8.34e-10 Crohn's disease; CRC cis rs28386778 0.897 rs2665796 chr17:61923716 G/C cg25654072 chr17:61904446 PSMC5;FTSJ3 0.7 10.94 0.52 5.62e-24 Prudent dietary pattern; CRC cis rs924607 1.000 rs2455331 chr5:643593 T/C cg04476341 chr5:669733 TPPP 0.42 6.9 0.36 2.63e-11 Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia; CRC cis rs826838 0.616 rs10880754 chr12:38628154 C/T cg13010199 chr12:38710504 ALG10B -0.42 -6.03 -0.32 4.3e-9 Heart rate; CRC cis rs6502050 0.835 rs7221544 chr17:80087337 C/T cg19223190 chr17:80058835 NA -0.39 -6.07 -0.32 3.62e-9 Life satisfaction; CRC cis rs1552244 0.554 rs34883592 chr3:10046165 C/T cg08888203 chr3:10149979 C3orf24 0.48 7.32 0.37 1.9e-12 Alzheimer's disease; CRC cis rs34787248 1 rs34787248 chr6:28197886 C/T cg12172441 chr6:28176163 NA 0.6 6.3 0.33 9.49e-10 Autism spectrum disorder or schizophrenia; CRC cis rs2295359 0.892 rs6688383 chr1:67655954 C/T cg17031739 chr1:67600172 NA -0.38 -6.04 -0.32 4.19e-9 Psoriasis; CRC cis rs6942756 1.000 rs7780886 chr7:128879347 G/A cg02491457 chr7:128862824 NA -0.77 -10.7 -0.51 4.06e-23 White matter hyperintensity burden; CRC trans rs3794271 0.706 rs9971816 chr12:20826911 C/T cg01056903 chr20:44601024 ZNF335 0.46 6.24 0.33 1.33e-9 Response to TNF-alpha inhibitors in rheumatoid arthritis; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg02808110 chr17:34957846 MRM1 0.45 6.09 0.32 3.17e-9 Response to antipsychotic treatment; CRC cis rs6062302 0.522 rs6090476 chr20:62248001 G/A cg16989086 chr20:62203971 PRIC285 0.51 6.53 0.34 2.55e-10 Glioblastoma; CRC cis rs9910055 0.718 rs7212854 chr17:42254417 A/G cg10896456 chr17:42255109 ASB16;C17orf65 0.45 7.3 0.37 2.17e-12 Total body bone mineral density; CRC cis rs55871839 0.708 rs10112089 chr8:59813429 C/T cg07426533 chr8:59803705 TOX -0.34 -5.94 -0.31 7.22e-9 Pneumonia; CRC cis rs2310173 0.575 rs2110563 chr2:102628433 T/G cg20856504 chr2:102616538 IL1R2 0.39 6.12 0.32 2.68e-9 Ankylosing spondylitis;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined);Ulcerative colitis; CRC trans rs7726839 0.561 rs4957050 chr5:579066 A/C cg25482853 chr8:67687455 SGK3 1.01 12.23 0.56 1.28e-28 Obesity-related traits; CRC cis rs1475911 0.708 rs8129075 chr21:43523430 G/T cg14562523 chr21:43528734 C21orf128;UMODL1 -0.65 -10.35 -0.5 6.5600000000000005e-22 IgG glycosylation; CRC cis rs78456975 0.622 rs11896517 chr2:1518112 A/G cg26248373 chr2:1572462 NA -0.67 -8.54 -0.43 5.23e-16 Placebo response in major depressive disorder (% change in symptom score); CRC cis rs853679 0.517 rs3173443 chr6:28137027 T/G cg15786705 chr6:28176104 NA 0.78 9.83 0.48 3.57e-20 Depression; CRC cis rs1150668 0.768 rs1233713 chr6:28198281 A/G cg02683197 chr6:28174875 NA 0.42 6.0 0.31 5.2e-9 Pubertal anthropometrics; CRC cis rs3931020 0.508 rs4145871 chr1:75218704 C/T cg10128416 chr1:75198403 TYW3;CRYZ 0.48 6.68 0.35 1e-10 Resistin levels; CRC cis rs2535633 0.820 rs7626551 chr3:52938092 C/G cg11645453 chr3:52864694 ITIH4 -0.36 -6.72 -0.35 7.94e-11 Body mass index; CRC cis rs7618915 0.501 rs2336146 chr3:52626646 A/G cg15147215 chr3:52552868 STAB1 -0.63 -10.88 -0.51 9.7e-24 Bipolar disorder; CRC cis rs6502050 0.835 rs3924781 chr17:80113130 T/C cg13198984 chr17:80129470 CCDC57 0.49 8.52 0.43 5.65e-16 Life satisfaction; CRC cis rs7772486 0.686 rs1337839 chr6:146010239 A/G cg23711669 chr6:146136114 FBXO30 -0.65 -10.49 -0.5 2.14e-22 Lobe attachment (rater-scored or self-reported); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg01490821 chr2:170684022 UBR3 0.45 6.14 0.32 2.44e-9 Response to antipsychotic treatment; CRC cis rs11098499 0.954 rs10014845 chr4:120301077 T/G cg24375607 chr4:120327624 NA 0.51 7.86 0.4 5.5e-14 Corneal astigmatism; CRC trans rs7267979 0.844 rs2257649 chr20:25263457 T/G cg17903999 chr18:56338584 MALT1 -0.42 -6.75 -0.35 6.68e-11 Liver enzyme levels (alkaline phosphatase); CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg01804284 chr1:41157659 NFYC;LOC100130557 -0.43 -6.82 -0.35 4.27e-11 Myopia (pathological); CRC cis rs2982552 0.773 rs11155809 chr6:152056058 A/G cg22157087 chr6:152012887 ESR1 0.37 5.66 0.3 3.31e-8 Bone properties (heel); CRC cis rs990171 1.000 rs7559479 chr2:103068787 C/T cg03938978 chr2:103052716 IL18RAP 0.48 6.1 0.32 3.03e-9 Lymphocyte counts; CRC trans rs148734725 1 rs148734725 chr3:49406708 G/A cg21659725 chr3:3221576 CRBN -0.65 -8.96 -0.44 2.56e-17 Educational attainment (college completion); CRC cis rs10979 0.965 rs9376759 chr6:143886959 G/A cg25407410 chr6:143891975 LOC285740 -0.78 -12.65 -0.57 3.66e-30 Hypospadias; CRC cis rs853679 0.550 rs1233699 chr6:28169158 A/T cg25164649 chr6:28176230 NA 0.79 11.02 0.52 2.91e-24 Depression; CRC cis rs6424115 0.965 rs2502979 chr1:24149315 C/A cg24699146 chr1:24152579 HMGCL 0.32 5.64 0.3 3.62e-8 Immature fraction of reticulocytes; CRC cis rs35306767 0.855 rs56222464 chr10:867535 C/G cg26597838 chr10:835615 NA 1.25 15.13 0.64 1.26e-39 Eosinophil percentage of granulocytes; CRC cis rs11958404 1.000 rs72816523 chr5:157403168 G/C cg05962755 chr5:157440814 NA 0.96 12.22 0.56 1.42e-28 IgG glycosylation; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg18663498 chr6:27487068 NA 0.52 7.35 0.38 1.61e-12 Response to antipsychotic treatment; CRC cis rs10971721 0.642 rs114466241 chr9:33835729 A/G cg13495928 chr9:33750294 PRSS3 0.55 5.93 0.31 7.7e-9 Body mass index; CRC cis rs4780401 0.693 rs8191277 chr16:11764082 A/G cg01061890 chr16:11836724 TXNDC11 -0.42 -5.76 -0.3 1.95e-8 Rheumatoid arthritis; CRC cis rs11098499 0.954 rs10006706 chr4:120409152 A/G cg24375607 chr4:120327624 NA 0.48 7.44 0.38 9.13e-13 Corneal astigmatism; CRC cis rs2153535 0.580 rs7450817 chr6:8481421 G/A cg21535247 chr6:8435926 SLC35B3 0.5 7.51 0.38 5.54e-13 Motion sickness; CRC cis rs7727544 0.836 rs10463892 chr5:131598705 T/C cg18758796 chr5:131593413 PDLIM4 0.33 6.18 0.32 1.94e-9 Blood metabolite levels; CRC cis rs2795502 0.882 rs3123754 chr10:43339011 G/A cg20628663 chr10:43360327 NA -0.69 -10.81 -0.51 1.67e-23 Blood protein levels; CRC cis rs909002 0.772 rs10914452 chr1:32074575 G/A cg13919466 chr1:32135498 COL16A1 -0.31 -5.79 -0.3 1.67e-8 Intelligence (multi-trait analysis); CRC cis rs4819052 0.819 rs7279136 chr21:46692287 C/T cg11663144 chr21:46675770 NA -0.85 -14.5 -0.62 3.46e-37 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs2180341 0.883 rs7760748 chr6:127690062 C/T cg27446573 chr6:127587934 RNF146 0.94 13.54 0.6 1.62e-33 Breast cancer; CRC cis rs1448094 0.845 rs7966131 chr12:86350633 T/G cg18827107 chr12:86230957 RASSF9 -0.43 -6.82 -0.35 4.31e-11 Major depressive disorder; CRC trans rs1005277 0.579 rs1621040 chr10:38497232 T/C cg27523141 chr10:43048294 ZNF37B 0.47 6.88 0.35 2.98e-11 Extrinsic epigenetic age acceleration; CRC cis rs7615952 0.512 rs1077621 chr3:125819799 A/G cg18479299 chr3:125709523 NA -0.54 -6.41 -0.33 4.96e-10 Blood pressure (smoking interaction); CRC cis rs826838 0.967 rs34496261 chr12:39023829 G/A cg13010199 chr12:38710504 ALG10B 0.45 5.88 0.31 1.01e-8 Heart rate; CRC cis rs1005277 0.522 rs1208681 chr10:38092975 C/T cg00409905 chr10:38381863 ZNF37A -0.63 -10.26 -0.49 1.3e-21 Extrinsic epigenetic age acceleration; CRC cis rs853679 0.760 rs9393910 chr6:28208192 C/G cg15786705 chr6:28176104 NA 0.62 6.67 0.34 1.11e-10 Depression; CRC cis rs2658782 0.738 rs2605628 chr11:93261560 C/A cg15737290 chr11:93063684 CCDC67 0.57 7.91 0.4 3.9e-14 Pulmonary function decline; CRC cis rs2834256 0.625 rs2834246 chr21:35050225 C/T cg14850771 chr21:34775459 IFNGR2 -0.47 -6.99 -0.36 1.5e-11 Red cell distribution width; CRC cis rs2072510 0.569 rs61937880 chr12:96390867 C/A cg09636302 chr12:96389483 HAL -0.52 -6.37 -0.33 6.21e-10 Metabolite levels (small molecules and protein measures); CRC cis rs7927771 0.832 rs896816 chr11:47394338 T/C cg20307385 chr11:47447363 PSMC3 0.62 9.27 0.46 2.44e-18 Subjective well-being; CRC cis rs9443645 0.901 rs1354832 chr6:79613763 A/G cg11833968 chr6:79620685 NA 0.37 6.5 0.34 2.97e-10 Intelligence (multi-trait analysis); CRC cis rs9443645 0.869 rs7756858 chr6:79619968 A/G cg11833968 chr6:79620685 NA -0.35 -6.05 -0.32 3.89e-9 Intelligence (multi-trait analysis); CRC cis rs9467711 0.559 rs12176129 chr6:26514940 C/T cg12315302 chr6:26189340 HIST1H4D 0.75 6.29 0.33 9.83e-10 Autism spectrum disorder or schizophrenia; CRC cis rs10089 1.000 rs13357268 chr5:127423051 G/A cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.7 9.65 0.47 1.48e-19 Ileal carcinoids; CRC cis rs2457480 0.733 rs1545845 chr10:44679802 A/C cg09554077 chr10:44749378 NA 0.5 6.98 0.36 1.62e-11 Coronary artery disease; CRC cis rs763014 0.593 rs28455838 chr16:681966 T/C cg00802000 chr16:706648 WDR90 -0.39 -5.62 -0.3 4.12e-8 Height; CRC cis rs7666738 0.830 rs921521 chr4:98838339 A/G cg05340658 chr4:99064831 C4orf37 0.58 8.46 0.42 8.79e-16 Colonoscopy-negative controls vs population controls; CRC cis rs2576037 0.623 rs2571000 chr18:44580347 G/A cg07416455 chr18:44543612 TCEB3CL;KATNAL2 0.63 9.18 0.45 5.08e-18 Personality dimensions; CRC cis rs9914988 0.943 rs4794838 chr17:27131095 T/C cg20469991 chr17:27169893 C17orf63 -0.6 -7.27 -0.37 2.59e-12 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs116095464 0.558 rs7713524 chr5:276200 C/T cg22496380 chr5:211416 CCDC127 0.87 9.59 0.47 2.33e-19 Breast cancer; CRC cis rs1005277 0.505 rs200939 chr10:38139483 T/C cg25517755 chr10:38738941 LOC399744 -0.45 -6.61 -0.34 1.53e-10 Extrinsic epigenetic age acceleration; CRC trans rs7615952 0.546 rs11711150 chr3:125315663 C/T cg02560186 chr11:3602584 NA -0.57 -6.89 -0.36 2.85e-11 Blood pressure (smoking interaction); CRC cis rs2762353 0.595 rs9467591 chr6:25742699 C/T cg03264133 chr6:25882463 NA -0.69 -9.74 -0.47 7.15e-20 Blood metabolite levels; CRC cis rs9322193 0.884 rs11155689 chr6:150129606 T/C cg00933542 chr6:150070202 PCMT1 0.28 5.64 0.3 3.7e-8 Lung cancer; CRC cis rs926938 0.541 rs360623 chr1:115407268 G/C cg12756093 chr1:115239321 AMPD1 0.56 8.18 0.41 6.15e-15 Autism; CRC cis rs1401999 0.546 rs56889301 chr3:183675315 T/C cg20387954 chr3:183756860 HTR3D 0.36 6.05 0.32 3.95e-9 Anterior chamber depth; CRC cis rs8180040 0.768 rs11915074 chr3:47309757 A/T cg02527881 chr3:46936655 PTH1R 0.35 5.99 0.31 5.4e-9 Colorectal cancer; CRC trans rs2303319 0.504 rs62189048 chr2:162613494 G/C cg03774468 chr3:140950104 ACPL2 -0.65 -6.07 -0.32 3.61e-9 Cognitive function; CRC cis rs7264396 1.000 rs224437 chr20:34154371 C/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.47 -7.78 -0.39 9.16e-14 Total cholesterol levels; CRC cis rs10791323 0.593 rs11223599 chr11:133717902 A/T cg15485101 chr11:133734466 NA -0.39 -6.66 -0.34 1.13e-10 Childhood ear infection; CRC cis rs60843830 1.000 rs7566279 chr2:281178 C/G cg25945732 chr2:264204 ACP1;SH3YL1 0.71 11.63 0.54 1.94e-26 Spherical equivalent (joint analysis main effects and education interaction); CRC trans rs7647973 0.593 rs7620848 chr3:49828021 G/C cg21665057 chr3:196295764 WDR53;FBXO45 0.61 6.76 0.35 6.4e-11 Menarche (age at onset); CRC cis rs6951245 0.872 rs75398423 chr7:1098414 T/G cg18402987 chr7:1209562 NA 0.67 7.17 0.37 5.02e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs7824557 0.583 rs6601585 chr8:11233659 A/G cg20542592 chr8:11973495 FAM66D 0.35 6.15 0.32 2.28e-9 Retinal vascular caliber; CRC trans rs9528384 0.599 rs9645948 chr13:62269878 T/C cg08375866 chr1:50799151 NA -0.32 -6.0 -0.31 5.08e-9 Verbal declarative memory; CRC cis rs7647973 0.710 rs12637313 chr3:49645458 A/G cg03060546 chr3:49711283 APEH 0.66 7.69 0.39 1.69e-13 Menarche (age at onset); CRC cis rs881375 0.967 rs2416805 chr9:123676482 T/C cg14255062 chr9:123606675 PSMD5;LOC253039 0.42 6.08 0.32 3.29e-9 Rheumatoid arthritis; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg03366677 chr14:77495018 C14orf4 0.42 6.11 0.32 2.89e-9 Response to antipsychotic treatment; CRC trans rs9858542 0.953 rs3811697 chr3:49590770 C/T cg21665057 chr3:196295764 WDR53;FBXO45 -0.67 -9.18 -0.45 4.77e-18 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs59104589 0.517 rs1064767 chr2:242167337 T/C cg19488206 chr2:242435732 STK25 0.39 6.07 0.32 3.49e-9 Fibrinogen levels; CRC cis rs10463316 0.894 rs869198 chr5:150745893 G/T cg03212797 chr5:150827313 SLC36A1 0.52 7.96 0.4 2.91e-14 Metabolite levels (Pyroglutamine); CRC cis rs8180040 1.000 rs8180040 chr3:47388947 A/T cg27129171 chr3:47204927 SETD2 0.67 10.45 0.5 2.98e-22 Colorectal cancer; CRC trans rs12495832 0.778 rs56373533 chr3:147940311 G/A cg10221266 chr7:153579447 NA 0.59 6.34 0.33 7.77e-10 Chin dimples; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg12525736 chr1:228269915 ARF1 0.45 7.35 0.38 1.57e-12 Liver disease severity in Alagille syndrome; CRC cis rs939658 0.805 rs8024813 chr15:79427260 A/G cg17916960 chr15:79447300 NA -0.45 -7.38 -0.38 1.34e-12 Refractive error; CRC cis rs9443645 0.901 rs1960542 chr6:79566643 C/T cg11833968 chr6:79620685 NA -0.36 -6.36 -0.33 6.72e-10 Intelligence (multi-trait analysis); CRC cis rs7074356 0.688 rs34894697 chr10:82169888 T/C cg27171509 chr10:82033454 MAT1A -0.45 -7.75 -0.39 1.18e-13 Borderline personality disorder; CRC cis rs9326248 1.000 rs585849 chr11:117069061 A/G cg26566898 chr11:117069891 TAGLN 0.44 9.59 0.47 2.25e-19 Blood protein levels; CRC cis rs2732480 0.557 rs2634682 chr12:48732943 T/C cg21466736 chr12:48725269 NA -0.61 -9.15 -0.45 6.31e-18 Hemoglobin concentration;Red blood cell count;Hematocrit; CRC trans rs9329221 0.521 rs4841294 chr8:10105068 G/T cg06636001 chr8:8085503 FLJ10661 -0.53 -8.09 -0.41 1.15e-14 Neuroticism; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg00757413 chr9:130160153 SLC2A8 0.41 6.3 0.33 9.79e-10 Liver disease severity in Alagille syndrome; CRC cis rs6088590 1.000 rs3787222 chr20:33333040 T/A cg24642439 chr20:33292090 TP53INP2 0.59 10.67 0.51 5.2e-23 Coronary artery disease; CRC cis rs875971 1.000 rs6958277 chr7:65979349 A/G cg00343986 chr7:65444356 GUSB 0.44 6.46 0.34 3.84e-10 Aortic root size; CRC cis rs10504229 0.679 rs72649109 chr8:58031274 A/T cg08219700 chr8:58056026 NA 0.55 6.56 0.34 2.15e-10 Developmental language disorder (linguistic errors); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg06451949 chr17:48942959 NA 0.43 6.0 0.31 5.1e-9 Response to antipsychotic treatment; CRC trans rs9467711 0.606 rs13190739 chr6:26587373 G/T cg06606381 chr12:133084897 FBRSL1 -1.07 -7.41 -0.38 1.09e-12 Autism spectrum disorder or schizophrenia; CRC cis rs2836974 0.931 rs2735306 chr21:40713134 A/G cg11890956 chr21:40555474 PSMG1 -0.98 -15.22 -0.64 5.66e-40 Cognitive function; CRC cis rs10949834 0.504 rs12539781 chr7:73568425 C/T cg07137043 chr7:73588983 EIF4H -0.6 -6.85 -0.35 3.54e-11 Verbal memory performance (residualized delayed recall change); CRC cis rs7618915 0.547 rs35211965 chr3:52685305 C/G cg08222913 chr3:52553049 STAB1 -0.34 -6.12 -0.32 2.7e-9 Bipolar disorder; CRC cis rs3764400 0.567 rs741058 chr17:46205353 T/C cg10706073 chr17:46328419 SKAP1 0.58 6.26 0.33 1.22e-9 Body mass index; CRC cis rs1552244 1.000 rs17032278 chr3:10077955 A/G cg00166722 chr3:10149974 C3orf24 0.71 9.49 0.46 4.86e-19 Alzheimer's disease; CRC cis rs11958404 0.789 rs7736318 chr5:157477593 A/G cg05962755 chr5:157440814 NA 0.99 12.66 0.57 3.33e-30 IgG glycosylation; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg16075951 chr14:24899050 CBLN3;KHNYN 0.37 6.03 0.32 4.32e-9 Liver disease severity in Alagille syndrome; CRC cis rs1200821 0.529 rs2475206 chr10:37802532 A/G cg00409905 chr10:38381863 ZNF37A 0.5 7.62 0.39 2.78e-13 Hemostatic factors and hematological phenotypes; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg06617136 chr1:145470297 ANKRD34A;POLR3GL 0.49 7.06 0.36 1.02e-11 Response to antipsychotic treatment; CRC cis rs55823223 0.680 rs57287238 chr17:73850940 T/C cg10935138 chr17:73851978 WBP2 0.65 7.85 0.4 5.8e-14 Psoriasis; CRC trans rs12310956 0.532 rs11052933 chr12:33969881 G/A cg26384229 chr12:38710491 ALG10B 0.51 6.44 0.33 4.25e-10 Morning vs. evening chronotype; CRC cis rs1552172 0.853 rs11587821 chr1:145599038 G/T cg11743829 chr1:145714124 CD160 -0.41 -6.14 -0.32 2.34e-9 Breast cancer; CRC cis rs1670533 1.000 rs688785 chr4:1082707 G/C cg27284194 chr4:1044797 NA 0.49 6.24 0.33 1.37e-9 Recombination rate (females); CRC trans rs10180663 0.649 rs10189164 chr2:25633368 C/G cg26118698 chr21:47599972 C21orf56 0.4 6.37 0.33 6.55e-10 Multiple myeloma (IgH translocation); CRC cis rs2386661 0.547 rs11259742 chr10:5647078 C/T cg12223502 chr10:5658492 NA -0.36 -5.9 -0.31 9.03e-9 Breast cancer; CRC cis rs6952808 0.609 rs10274300 chr7:1950405 C/G cg22963979 chr7:1858916 MAD1L1 -0.42 -6.68 -0.35 1.01e-10 Bipolar disorder and schizophrenia; CRC cis rs7107174 0.901 rs4944199 chr11:78122779 A/G cg12700464 chr11:78128424 GAB2 -0.5 -5.8 -0.3 1.52e-8 Testicular germ cell tumor; CRC cis rs6738485 0.507 rs66569888 chr2:106886967 G/A cg16099169 chr2:106886729 NA -0.66 -10.71 -0.51 3.73e-23 Pursuit maintenance gain;Pursuit maintenance gain in psychotic disorders; CRC cis rs853679 0.882 rs9380069 chr6:28203300 A/G cg06470822 chr6:28175283 NA 0.7 5.93 0.31 7.71e-9 Depression; CRC cis rs9787249 0.957 rs12239844 chr1:40217258 T/C cg01941586 chr1:40203715 PPIE -0.42 -5.94 -0.31 7.23e-9 Blood protein levels; CRC cis rs13108904 0.901 rs4493484 chr4:1279944 G/A cg05665937 chr4:1216051 CTBP1 0.4 5.78 0.3 1.74e-8 Obesity-related traits; CRC cis rs60871478 0.898 rs4725241 chr7:796883 C/T cg13844804 chr7:814759 HEATR2 0.65 8.52 0.42 6.01e-16 Cerebrospinal P-tau181p levels; CRC cis rs7666738 0.791 rs1527516 chr4:98967937 A/C cg17366294 chr4:99064904 C4orf37 0.42 7.02 0.36 1.27e-11 Colonoscopy-negative controls vs population controls; CRC cis rs2404602 0.710 rs2469541 chr15:76562118 C/T cg22467129 chr15:76604101 ETFA 0.5 8.94 0.44 2.84e-17 Blood metabolite levels; CRC cis rs3806843 0.932 rs2563257 chr5:140140529 A/G cg19875535 chr5:140030758 IK -0.55 -8.8 -0.44 7.81e-17 Depressive symptoms (multi-trait analysis); CRC cis rs2882667 0.867 rs11749045 chr5:138420960 C/T cg09476006 chr5:138032270 NA 0.4 6.68 0.35 9.91e-11 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs875971 0.545 rs6460276 chr7:65647277 G/A cg11764359 chr7:65958608 NA 0.46 5.89 0.31 9.34e-9 Aortic root size; CRC cis rs713587 0.563 rs10865315 chr2:25100738 C/A cg04586622 chr2:25135609 ADCY3 -0.56 -10.26 -0.49 1.3e-21 Body mass index in non-asthmatics; CRC cis rs2949837 0.504 rs2342396 chr7:45968087 C/G cg15898840 chr7:45960834 IGFBP3 0.42 7.09 0.36 8.2e-12 Sitting height ratio; CRC cis rs4474465 0.850 rs7127028 chr11:78262324 A/G cg27205649 chr11:78285834 NARS2 0.49 6.39 0.33 5.64e-10 Alzheimer's disease (survival time); CRC cis rs1018836 0.892 rs4735224 chr8:91567046 C/A cg16814680 chr8:91681699 NA -0.6 -9.12 -0.45 7.49e-18 Ejection fraction in Tripanosoma cruzi seropositivity; CRC cis rs13256369 0.802 rs12681925 chr8:8561649 G/A cg18904891 chr8:8559673 CLDN23 0.53 7.02 0.36 1.26e-11 Obesity-related traits; CRC cis rs3820068 0.603 rs16851884 chr1:15961871 A/G cg13390004 chr1:15929781 NA 0.5 7.07 0.36 9.19e-12 Systolic blood pressure; CRC trans rs75804782 0.691 rs55886641 chr2:239319185 T/C cg01134436 chr17:81009848 B3GNTL1 0.77 7.02 0.36 1.24e-11 Morning vs. evening chronotype;Chronotype; CRC cis rs7772486 0.790 rs9376970 chr6:146241472 A/C cg13319975 chr6:146136371 FBXO30 0.45 6.78 0.35 5.68e-11 Lobe attachment (rater-scored or self-reported); CRC cis rs2408955 0.522 rs11168408 chr12:48498327 G/A cg21466736 chr12:48725269 NA 0.51 7.7 0.39 1.6e-13 Glycated hemoglobin levels; CRC trans rs4332037 0.707 rs62435132 chr7:1891315 C/T cg11693508 chr17:37793320 STARD3 0.64 8.24 0.41 4.16e-15 Bipolar disorder; CRC cis rs4423214 0.592 rs78300366 chr11:71205514 A/G cg05163923 chr11:71159392 DHCR7 -0.56 -5.78 -0.3 1.77e-8 Vitamin D levels; CRC cis rs11628318 0.853 rs28444760 chr14:103041148 A/G cg02094049 chr14:103021097 NA -0.57 -7.51 -0.38 5.56e-13 Platelet count; CRC cis rs62103177 0.810 rs62103189 chr18:77627815 G/A cg12964065 chr18:77638022 KCNG2 0.66 6.69 0.35 9.56e-11 Opioid sensitivity; CRC cis rs13108904 0.870 rs13110563 chr4:1255772 G/C cg20092199 chr4:1342459 KIAA1530 0.34 5.95 0.31 6.74e-9 Obesity-related traits; CRC cis rs9916302 0.706 rs6503504 chr17:37514412 A/G cg15445000 chr17:37608096 MED1 -0.35 -6.12 -0.32 2.59e-9 Glomerular filtration rate (creatinine); CRC cis rs12586317 0.547 rs10130773 chr14:35445299 G/A cg16230307 chr14:35515116 FAM177A1 0.88 10.19 0.49 2.18e-21 Psoriasis; CRC cis rs172166 0.694 rs536704 chr6:28092603 T/G cg12172441 chr6:28176163 NA 0.52 7.19 0.37 4.33e-12 Cardiac Troponin-T levels; CRC cis rs79349575 0.783 rs62078372 chr17:47028989 T/C cg00947319 chr17:47005597 UBE2Z -0.33 -5.67 -0.3 3.19e-8 Type 2 diabetes; CRC cis rs1008375 1.000 rs9291659 chr4:17662360 A/C cg16339924 chr4:17578868 LAP3 0.55 7.14 0.37 6.01e-12 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs2836974 0.831 rs6517521 chr21:40551588 A/G cg11890956 chr21:40555474 PSMG1 1.08 18.29 0.71 4.62e-52 Cognitive function; CRC cis rs8180040 0.800 rs62248905 chr3:47274082 A/G cg27129171 chr3:47204927 SETD2 -0.68 -10.39 -0.5 4.54e-22 Colorectal cancer; CRC cis rs875971 0.862 rs6952182 chr7:65683317 T/G cg18876405 chr7:65276391 NA -0.54 -8.74 -0.43 1.24e-16 Aortic root size; CRC cis rs10254118 0.730 rs6961517 chr7:133130940 G/T cg10665199 chr7:133106180 EXOC4 0.66 10.55 0.5 1.3e-22 Intelligence (multi-trait analysis); CRC cis rs796364 0.906 rs281784 chr2:200749749 T/A cg25936922 chr2:200820526 C2orf60;C2orf47 0.72 8.02 0.4 1.87e-14 Schizophrenia; CRC cis rs9875589 0.509 rs6768383 chr3:14076952 G/A cg14375111 chr3:14165186 TMEM43;CHCHD4 0.41 6.03 0.32 4.35e-9 Ovarian reserve; CRC cis rs6502050 0.835 rs9891962 chr17:80153594 T/C cg19223190 chr17:80058835 NA 0.41 6.57 0.34 1.93e-10 Life satisfaction; CRC cis rs9311676 0.618 rs12152337 chr3:58365271 T/C cg06643156 chr3:58380774 PXK 0.42 6.55 0.34 2.17e-10 Systemic lupus erythematosus; CRC cis rs847577 0.677 rs4729403 chr7:97707841 G/C cg24562669 chr7:97807699 LMTK2 -0.68 -12.73 -0.57 1.88e-30 Breast cancer; CRC cis rs9462027 0.628 rs9368832 chr6:34679587 C/T cg07306190 chr6:34760872 UHRF1BP1 0.37 6.63 0.34 1.35e-10 Systemic lupus erythematosus; CRC cis rs9768139 0.708 rs10234067 chr7:158114542 C/T cg25566285 chr7:158114605 PTPRN2 0.52 8.58 0.43 3.77e-16 Calcium levels; CRC cis rs2274273 0.840 rs2341622 chr14:55737243 C/A cg23234261 chr14:55582407 NA -0.3 -5.97 -0.31 6.17e-9 Protein biomarker; CRC cis rs7591163 1.000 rs6436741 chr2:228714598 G/A cg14329157 chr2:228736135 WDR69 -0.47 -6.53 -0.34 2.48e-10 Blood pressure; CRC cis rs8031584 0.958 rs11629793 chr15:31238423 G/A cg08109568 chr15:31115862 NA -0.51 -8.36 -0.42 1.77e-15 Huntington's disease progression; CRC trans rs2303319 0.504 rs1449641 chr2:162619567 T/C cg25193742 chr10:104614220 C10orf32 -0.76 -6.46 -0.34 3.66e-10 Cognitive function; CRC cis rs9381040 0.655 rs7738684 chr6:41038552 G/A cg03644281 chr6:41068752 NFYA;LOC221442 -0.46 -6.52 -0.34 2.6200000000000003e-10 Alzheimer's disease (late onset); CRC cis rs9487051 0.676 rs6928622 chr6:109595112 C/T cg21918786 chr6:109611834 NA -0.41 -7.17 -0.37 4.84e-12 Reticulocyte fraction of red cells; CRC cis rs6964587 1.000 rs11971885 chr7:91674807 T/C cg17063962 chr7:91808500 NA 0.78 13.53 0.6 1.81e-33 Breast cancer; CRC cis rs6840360 0.593 rs4696287 chr4:152606723 C/T cg09659197 chr4:152720779 NA 0.4 7.98 0.4 2.49e-14 Intelligence (multi-trait analysis); CRC cis rs727505 0.563 rs73227531 chr7:124800221 T/A cg23710748 chr7:124431027 NA -0.64 -10.42 -0.5 3.58e-22 Lewy body disease; CRC cis rs736408 0.648 rs3774354 chr3:52817675 G/A cg10802521 chr3:52805072 NEK4 -0.57 -8.21 -0.41 4.98e-15 Bipolar disorder; CRC trans rs2303319 0.504 rs56965753 chr2:162597251 A/G cg13490827 chr1:46269305 MAST2 -0.69 -6.0 -0.31 5.24e-9 Cognitive function; CRC trans rs208520 1.000 rs12216109 chr6:66987488 C/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.89 10.88 0.51 9.5e-24 Exhaled nitric oxide output; CRC cis rs72634258 0.945 rs1883679 chr1:8100451 T/G cg26816564 chr1:7831052 VAMP3 0.55 6.14 0.32 2.36e-9 Inflammatory bowel disease; CRC cis rs875971 0.862 rs801206 chr7:66021966 C/G cg18876405 chr7:65276391 NA -0.52 -8.41 -0.42 1.27e-15 Aortic root size; CRC cis rs2836974 0.666 rs4624474 chr21:40686327 T/C cg11890956 chr21:40555474 PSMG1 -0.83 -13.07 -0.58 9.83e-32 Cognitive function; CRC cis rs2228479 0.850 rs11646766 chr16:89838578 A/T cg06558623 chr16:89946397 TCF25 1.15 10.84 0.51 1.3e-23 Skin colour saturation; CRC cis rs11997175 0.646 rs7005018 chr8:33700210 A/G ch.8.33884649F chr8:33765107 NA 0.46 6.68 0.35 1.01e-10 Body mass index; CRC cis rs12541635 0.934 rs11776139 chr8:106983966 A/G cg10147462 chr8:107024639 NA 0.47 7.67 0.39 2.02e-13 Age of smoking initiation; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg08541953 chr1:6259338 RPL22 0.51 6.68 0.35 1.02e-10 Thyroid stimulating hormone; CRC cis rs6502050 0.871 rs8072702 chr17:80074280 C/T cg22110888 chr17:80059540 CCDC57 -0.43 -6.69 -0.35 9.52e-11 Life satisfaction; CRC cis rs933688 1.000 rs11950530 chr5:90688740 A/G cg02339078 chr5:90679543 LOC100129716;ARRDC3 0.92 13.87 0.61 9.28e-35 Smoking behavior; CRC cis rs881375 0.715 rs10985073 chr9:123643855 T/C cg09419670 chr9:123605666 PSMD5;LOC253039 0.52 8.22 0.41 4.83e-15 Rheumatoid arthritis; CRC cis rs11190604 1.000 rs7079136 chr10:102292709 T/C cg07080220 chr10:102295463 HIF1AN 0.47 5.65 0.3 3.39e-8 Palmitoleic acid (16:1n-7) levels; CRC cis rs2070677 0.799 rs11101854 chr10:135394430 G/A cg20169779 chr10:135381914 SYCE1 -0.94 -14.89 -0.63 1.09e-38 Gout; CRC cis rs9914988 1.000 rs9914988 chr17:27183104 G/A cg20469991 chr17:27169893 C17orf63 0.47 5.85 0.31 1.2e-8 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs7274811 0.554 rs6120299 chr20:32133491 T/G cg07470512 chr20:32255052 NECAB3;C20orf134 -0.44 -5.66 -0.3 3.31e-8 Height; CRC cis rs2688482 0.557 rs3103952 chr3:195522690 T/C cg12923728 chr3:195709715 SDHAP1 -0.6 -6.28 -0.33 1.07e-9 Lung disease severity in cystic fibrosis; CRC cis rs1448094 0.510 rs11117016 chr12:86141602 T/C cg00310523 chr12:86230176 RASSF9 -0.38 -6.14 -0.32 2.4e-9 Major depressive disorder; CRC cis rs7804356 0.861 rs115453073 chr7:26852741 A/T cg03456212 chr7:26904342 SKAP2 -0.52 -5.68 -0.3 2.98e-8 Type 1 diabetes; CRC cis rs1552244 1.000 rs7622966 chr3:10139833 C/T cg08888203 chr3:10149979 C3orf24 0.67 9.77 0.47 6.02e-20 Alzheimer's disease; CRC cis rs514406 0.893 rs499195 chr1:53344907 C/T cg27535305 chr1:53392650 SCP2 -0.39 -7.18 -0.37 4.66e-12 Monocyte count; CRC cis rs7635838 0.654 rs346083 chr3:11280017 T/C cg00170343 chr3:11313890 ATG7 0.56 8.41 0.42 1.25e-15 HDL cholesterol; CRC cis rs10540 1.000 rs35255804 chr11:492617 G/A cg19913688 chr11:428466 ANO9 -0.7 -7.21 -0.37 3.76e-12 Body mass index; CRC cis rs10789491 1.000 rs1371834 chr1:47176894 G/A cg15501359 chr1:47185051 KIAA0494 0.76 9.15 0.45 6.19e-18 Response to hepatitis C treatment; CRC trans rs2303319 0.504 rs12474470 chr2:162535336 T/C cg12500891 chr11:57225987 NA -0.68 -6.07 -0.32 3.55e-9 Cognitive function; CRC cis rs977987 0.898 rs12918974 chr16:75493943 T/A cg03315344 chr16:75512273 CHST6 0.6 10.23 0.49 1.66e-21 Dupuytren's disease; CRC cis rs11190604 1.000 rs2495742 chr10:102331364 C/T cg16342193 chr10:102329863 NA -0.4 -6.49 -0.34 3.23e-10 Palmitoleic acid (16:1n-7) levels; CRC cis rs7772486 0.777 rs1546966 chr6:146386018 G/T cg23711669 chr6:146136114 FBXO30 0.63 10.3 0.49 9.29e-22 Lobe attachment (rater-scored or self-reported); CRC cis rs1707322 0.890 rs2297883 chr1:46511487 G/C cg03146154 chr1:46216737 IPP -0.51 -7.09 -0.36 8.16e-12 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs926938 0.527 rs360685 chr1:115499795 G/C cg12756093 chr1:115239321 AMPD1 0.47 6.84 0.35 3.86e-11 Autism; CRC cis rs4972806 0.814 rs4246626 chr2:177046430 A/C cg13092806 chr2:177043255 NA 0.8 13.09 0.59 8.21e-32 IgG glycosylation; CRC cis rs2067615 0.524 rs4964187 chr12:107080313 C/A cg15890332 chr12:107067104 RFX4 0.32 5.65 0.3 3.42e-8 Heart rate; CRC cis rs2075671 0.855 rs62483567 chr7:100286435 G/A cg00334542 chr7:100209784 MOSPD3 -0.52 -6.69 -0.35 9.7e-11 Other erythrocyte phenotypes; CRC cis rs2294693 0.891 rs4714421 chr6:40992837 C/T cg14769373 chr6:40998127 UNC5CL -0.48 -6.37 -0.33 6.37e-10 Gastric cancer;Non-cardia gastric cancer; CRC cis rs997295 0.570 rs737226 chr15:67840773 T/C cg24247231 chr15:67904302 MAP2K5 -0.34 -5.96 -0.31 6.63e-9 Motion sickness; CRC cis rs4665809 0.590 rs13016300 chr2:26468365 G/C cg08067268 chr2:26466485 HADHB;HADHA 0.65 8.34 0.42 2e-15 Gut microbiome composition (summer); CRC cis rs6964587 0.934 rs6465344 chr7:91640273 G/A cg17063962 chr7:91808500 NA 0.83 14.89 0.63 1.05e-38 Breast cancer; CRC cis rs2075371 0.933 rs2544182 chr7:133949793 C/T cg02659138 chr7:134003124 SLC35B4 0.39 6.77 0.35 5.89e-11 Mean platelet volume; CRC cis rs7917772 0.582 rs4919665 chr10:104366042 C/T cg11453585 chr10:104263688 ACTR1A;SUFU -0.81 -15.04 -0.64 2.87e-39 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC cis rs1532331 0.864 rs6414900 chr5:43126528 G/A cg09164108 chr5:43007320 NA 0.37 5.68 0.3 3e-8 Menarche (age at onset); CRC cis rs2996428 0.561 rs12134919 chr1:3744641 G/A cg17848003 chr1:3704513 LRRC47 0.4 5.95 0.31 6.97e-9 Red cell distribution width; CRC trans rs2797160 0.935 rs926855 chr6:126021782 A/G cg05039488 chr6:79577232 IRAK1BP1 0.52 7.7 0.39 1.64e-13 Endometrial cancer; CRC cis rs4728302 0.703 rs3823572 chr7:133680601 G/A cg03336402 chr7:133662267 EXOC4 -0.47 -7.07 -0.36 9.59e-12 Intelligence;Intelligence (multi-trait analysis); CRC cis rs6743376 0.556 rs2472188 chr2:113820814 C/G cg09040174 chr2:113837401 NA 0.4 5.84 0.31 1.22e-8 Inflammatory biomarkers; CRC cis rs9916302 0.706 rs57933226 chr17:37412829 C/T cg15445000 chr17:37608096 MED1 0.37 6.68 0.35 1e-10 Glomerular filtration rate (creatinine); CRC cis rs10504229 0.775 rs72650876 chr8:58161638 G/A cg02290350 chr8:58132656 NA -0.5 -6.21 -0.32 1.6e-9 Developmental language disorder (linguistic errors); CRC cis rs4588572 0.688 rs2362829 chr5:77724036 T/A cg11446398 chr5:77624930 NA 0.42 6.06 0.32 3.65e-9 Triglycerides; CRC cis rs394563 0.967 rs447025 chr6:149799128 A/C cg07828024 chr6:149772892 ZC3H12D -0.48 -8.42 -0.42 1.15e-15 Dupuytren's disease; CRC cis rs6788895 0.661 rs57869178 chr3:150492826 G/C cg09723797 chr3:150481914 SIAH2 0.87 6.77 0.35 5.91e-11 Breast cancer; CRC cis rs1545257 0.537 rs2339948 chr2:24641012 A/T cg06627628 chr2:24431161 ITSN2 -0.45 -6.59 -0.34 1.71e-10 Sjögren's syndrome; CRC cis rs9915657 0.870 rs720244 chr17:70131643 G/T cg09344028 chr17:70110421 NA 0.44 6.65 0.34 1.2e-10 Thyroid hormone levels; CRC cis rs12681288 0.862 rs7814231 chr8:1021103 A/G cg15309053 chr8:964076 NA 0.41 7.27 0.37 2.64e-12 Schizophrenia; CRC cis rs7607369 0.714 rs4674338 chr2:219647487 A/G cg02176678 chr2:219576539 TTLL4 0.55 8.96 0.44 2.55e-17 Red blood cell count;Amyotrophic lateral sclerosis; CRC cis rs883565 0.612 rs784512 chr3:39165110 G/T cg01426195 chr3:39028469 NA 0.42 6.99 0.36 1.52e-11 Handedness; CRC cis rs1448094 0.544 rs56330110 chr12:86166666 A/G cg02569458 chr12:86230093 RASSF9 0.48 8.05 0.41 1.48e-14 Major depressive disorder; CRC cis rs2839186 0.500 rs13049893 chr21:47707054 C/T cg26721908 chr21:47610096 LSS -0.46 -6.56 -0.34 2.09e-10 Testicular germ cell tumor; CRC cis rs7626444 0.626 rs5021325 chr3:196477629 A/T cg12930392 chr3:196481615 PAK2 0.39 6.88 0.35 3.06e-11 Monocyte count; CRC cis rs7224685 0.501 rs781842 chr17:3958955 C/T cg11204139 chr17:3907470 NA 0.76 14.68 0.63 7.35e-38 Type 2 diabetes; CRC cis rs4555082 0.957 rs2816629 chr14:105737261 G/A cg18132624 chr14:105716052 BTBD6;BRF1 -0.43 -7.17 -0.37 4.86e-12 Mean platelet volume;Platelet distribution width; CRC cis rs9911578 0.757 rs4793954 chr17:56629527 G/T cg12560992 chr17:57184187 TRIM37 -0.85 -12.69 -0.57 2.69e-30 Intelligence (multi-trait analysis); CRC cis rs9814567 0.712 rs4306900 chr3:134334327 G/A cg06109529 chr3:134205091 CEP63;ANAPC13 0.68 9.74 0.47 7.29e-20 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs25422 0.938 rs9489443 chr6:118886163 T/A cg07617317 chr6:118971624 C6orf204 0.5 6.25 0.33 1.27e-9 Renal cell carcinoma; CRC cis rs6582630 0.519 rs11181526 chr12:38360230 A/G cg13010199 chr12:38710504 ALG10B 0.47 6.43 0.33 4.6e-10 Drug-induced liver injury (flucloxacillin); CRC trans rs1814175 0.519 rs3913237 chr11:49551828 G/A cg03929089 chr4:120376271 NA 0.76 10.23 0.49 1.69e-21 Height; CRC cis rs8180040 0.627 rs58956475 chr3:47224615 G/C cg27129171 chr3:47204927 SETD2 -0.72 -11.39 -0.53 1.46e-25 Colorectal cancer; CRC cis rs11098499 0.644 rs17517414 chr4:120262101 G/C cg09307838 chr4:120376055 NA 0.61 9.59 0.47 2.27e-19 Corneal astigmatism; CRC trans rs7618501 0.602 rs2071207 chr3:50159844 T/C cg21659725 chr3:3221576 CRBN -0.54 -8.57 -0.43 3.98e-16 Intelligence (multi-trait analysis); CRC cis rs11098499 0.955 rs13113112 chr4:120156040 C/T cg24375607 chr4:120327624 NA 0.47 7.36 0.38 1.48e-12 Corneal astigmatism; CRC cis rs79349575 0.783 rs318095 chr17:46974734 T/C cg00947319 chr17:47005597 UBE2Z -0.34 -5.94 -0.31 7.18e-9 Type 2 diabetes; CRC cis rs1401999 0.628 rs6798870 chr3:183740350 G/A cg05044414 chr3:183734942 ABCC5 0.41 7.28 0.37 2.5e-12 Anterior chamber depth; CRC cis rs4144743 1.000 rs34182248 chr17:45321359 T/C cg18085866 chr17:45331354 ITGB3 -0.59 -8.02 -0.4 1.86e-14 Body mass index; CRC cis rs782590 0.805 rs782578 chr2:55915904 A/C cg18811423 chr2:55921094 PNPT1 0.88 17.29 0.69 4.28e-48 Metabolic syndrome; CRC cis rs881375 0.967 rs1930778 chr9:123641369 A/C cg09419670 chr9:123605666 PSMD5;LOC253039 0.56 8.24 0.41 4.24e-15 Rheumatoid arthritis; CRC cis rs7584330 0.657 rs10202599 chr2:238352465 A/C cg14458575 chr2:238380390 NA 0.69 11.91 0.55 1.96e-27 Prostate cancer; CRC cis rs11155671 0.530 rs4458704 chr6:150232879 A/C cg13206674 chr6:150067644 NUP43 0.42 6.03 0.32 4.35e-9 Testicular germ cell tumor; CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg22146484 chr8:57123862 CHCHD7;PLAG1 -0.48 -5.99 -0.31 5.37e-9 Diisocyanate-induced asthma; CRC trans rs1005277 0.579 rs1548255 chr10:38417193 T/C cg27523141 chr10:43048294 ZNF37B 0.49 7.08 0.36 8.96e-12 Extrinsic epigenetic age acceleration; CRC cis rs9560113 0.922 rs4773377 chr13:112174152 G/C cg14154082 chr13:112174009 NA 0.35 5.71 0.3 2.54e-8 Menarche (age at onset); CRC cis rs1005277 0.522 rs289648 chr10:37971837 T/C cg00409905 chr10:38381863 ZNF37A -0.63 -10.07 -0.49 5.56e-21 Extrinsic epigenetic age acceleration; CRC cis rs7043114 0.544 rs7852510 chr9:95316359 T/G cg14631576 chr9:95140430 CENPP -0.3 -5.62 -0.3 3.97e-8 Height; CRC cis rs875971 1.000 rs1565531 chr7:65663113 T/A cg18912574 chr7:65842487 NCRNA00174 -0.37 -6.45 -0.34 3.99e-10 Aortic root size; CRC cis rs2228479 0.717 rs11649210 chr16:89807233 C/G cg04013166 chr16:89971882 TCF25 0.62 6.09 0.32 3.22e-9 Skin colour saturation; CRC cis rs9435341 0.929 rs1730865 chr1:107605611 A/C cg14828511 chr1:107599125 PRMT6 0.56 7.71 0.39 1.46e-13 Facial morphology (factor 21, depth of nasal alae); CRC cis rs13191362 1.000 rs73008453 chr6:163013384 G/A cg06582575 chr6:163149167 PACRG;PARK2 0.75 10.24 0.49 1.58e-21 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs66887589 0.967 rs1155577 chr4:120449810 C/T cg09307838 chr4:120376055 NA -0.52 -7.94 -0.4 3.17e-14 Diastolic blood pressure; CRC cis rs7833986 1.000 rs13273123 chr8:57100791 C/T cg23139584 chr8:56987506 RPS20;SNORD54 -0.63 -7.93 -0.4 3.34e-14 Height; CRC cis rs9549328 0.542 rs36172983 chr13:113616582 T/C cg24588162 chr13:113633484 MCF2L 0.36 6.43 0.33 4.47e-10 Systolic blood pressure; CRC cis rs4803468 0.901 rs3745292 chr19:41888506 A/G cg09537434 chr19:41945824 ATP5SL -0.95 -18.01 -0.7 6.09e-51 Height; CRC trans rs8108034 1.000 rs39587 chr19:39806997 C/T cg14358282 chr2:219866628 MIR375 -0.55 -5.97 -0.31 6.05e-9 Lung adenocarcinoma; CRC cis rs72781680 0.716 rs17045975 chr2:24099611 A/T cg08917208 chr2:24149416 ATAD2B -0.56 -6.81 -0.35 4.76e-11 Lymphocyte counts; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg06620269 chr17:2952258 NA 0.43 6.38 0.33 6.14e-10 Response to antipsychotic treatment; CRC cis rs9796 0.689 rs28497404 chr15:41449510 A/C cg18705301 chr15:41695430 NDUFAF1 -0.36 -5.85 -0.31 1.18e-8 Menopause (age at onset); CRC cis rs3785574 0.962 rs62077483 chr17:61806380 C/T cg06873352 chr17:61820015 STRADA 0.5 7.97 0.4 2.72e-14 Height; CRC cis rs853679 0.517 rs56310871 chr6:28044482 A/G cg02631126 chr6:28058918 ZSCAN12L1 0.29 6.1 0.32 2.95e-9 Depression; CRC cis rs6582630 0.599 rs8189525 chr12:38424982 A/C cg26384229 chr12:38710491 ALG10B 0.49 7.06 0.36 1.02e-11 Drug-induced liver injury (flucloxacillin); CRC cis rs1552244 1.000 rs9824585 chr3:10114802 T/C cg13047869 chr3:10149882 C3orf24 0.53 7.31 0.37 2.04e-12 Alzheimer's disease; CRC cis rs9378357 1.000 rs7750434 chr6:3281726 G/T cg08754725 chr6:3293098 SLC22A23 -0.57 -5.94 -0.31 7.12e-9 Obesity-related traits; CRC cis rs1971762 0.509 rs784567 chr12:53894465 C/T cg06632207 chr12:54070931 ATP5G2 -0.48 -8.03 -0.4 1.8e-14 Height; CRC cis rs887829 0.570 rs4261716 chr2:234593117 G/T cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.49 -7.61 -0.39 2.98e-13 Metabolic traits;Bilirubin levels;Cholelithiasis-related traits in sickle cell anemia;Metabolite levels;Total bilirubin levels in HIV-1 infection;Serum metabolite levels;Blood metabolite levels; CRC trans rs2727020 0.729 rs4980439 chr11:49342246 G/C cg03929089 chr4:120376271 NA -0.81 -14.37 -0.62 1.11e-36 Coronary artery disease; CRC cis rs477692 0.655 rs7906680 chr10:131442671 C/G cg05714579 chr10:131428358 MGMT -0.71 -10.82 -0.51 1.47e-23 Response to temozolomide; CRC trans rs1005277 0.579 rs2474575 chr10:38387901 C/T cg11292332 chr7:45801988 SEPT13 -0.35 -6.26 -0.33 1.18e-9 Extrinsic epigenetic age acceleration; CRC cis rs4332037 0.539 rs34571717 chr7:2106855 T/C cg02825527 chr7:2087843 MAD1L1 -0.4 -5.68 -0.3 3.03e-8 Bipolar disorder; CRC cis rs2836950 0.565 rs2150414 chr21:40614988 A/G cg11644478 chr21:40555479 PSMG1 -0.46 -6.72 -0.35 8.25e-11 Menarche (age at onset); CRC cis rs4664293 0.647 rs4665090 chr2:160453907 A/C cg08347373 chr2:160653686 CD302 -0.39 -6.49 -0.34 3.11e-10 Monocyte percentage of white cells; CRC cis rs12137294 0.794 rs1172160 chr1:205207015 G/A cg24159697 chr1:205181237 DSTYK -0.34 -6.25 -0.33 1.31e-9 Red cell distribution width; CRC cis rs2307022 0.586 rs1465467 chr16:68398432 A/G cg02226672 chr16:68398533 SMPD3 -0.29 -5.68 -0.3 2.9e-8 Body mass index; CRC cis rs892961 0.932 rs2170863 chr17:75415037 C/T cg05865280 chr17:75406074 SEPT9 0.62 13.95 0.61 4.63e-35 Airflow obstruction; CRC cis rs4731207 0.596 rs10081290 chr7:124575508 T/C cg23710748 chr7:124431027 NA -0.39 -6.19 -0.32 1.8e-9 Cutaneous malignant melanoma; CRC cis rs780096 0.546 rs715326 chr2:27725761 A/G cg21248554 chr2:27665150 KRTCAP3 0.3 6.97 0.36 1.7e-11 Total body bone mineral density; CRC cis rs6724607 1.000 rs4321393 chr2:191452899 G/T cg10560079 chr2:191398806 TMEM194B 0.48 6.75 0.35 6.71e-11 Pulse pressure; CRC cis rs17384381 0.859 rs12724823 chr1:85906385 G/T cg16011679 chr1:85725395 C1orf52 0.6 6.43 0.33 4.56e-10 Lobe attachment (rater-scored or self-reported); CRC cis rs4713118 0.824 rs9468229 chr6:27750086 G/A cg21251018 chr6:28226885 NKAPL 0.42 6.06 0.32 3.81e-9 Parkinson's disease; CRC cis rs11098499 0.874 rs6832670 chr4:120118792 A/G cg24375607 chr4:120327624 NA 0.48 7.25 0.37 3.02e-12 Corneal astigmatism; CRC cis rs9381040 0.610 rs2235678 chr6:41020510 G/T cg25110423 chr6:41068646 NFYA;LOC221442 -0.38 -5.83 -0.31 1.29e-8 Alzheimer's disease (late onset); CRC cis rs9828933 0.766 rs864975 chr3:63885615 T/C cg16258503 chr3:63850278 ATXN7;THOC7 0.82 8.28 0.42 3.17e-15 Type 2 diabetes; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg11522767 chr6:157342961 ARID1B 0.52 7.11 0.36 7.33e-12 Thyroid stimulating hormone; CRC cis rs8180040 0.768 rs11915074 chr3:47309757 A/T cg27129171 chr3:47204927 SETD2 -0.66 -9.98 -0.48 1.14e-20 Colorectal cancer; CRC cis rs1580019 0.813 rs2044839 chr7:32500805 A/C cg06627557 chr7:32535165 LSM5;AVL9 0.85 13.32 0.59 1.1e-32 Cognitive ability; CRC cis rs2836974 0.863 rs8132333 chr21:40527900 A/G cg11644478 chr21:40555479 PSMG1 0.84 13.68 0.6 5.07e-34 Cognitive function; CRC cis rs1862618 0.573 rs185220 chr5:56205357 A/G cg24531977 chr5:56204891 C5orf35 -1.01 -14.49 -0.62 3.9e-37 Initial pursuit acceleration; CRC cis rs9534288 0.797 rs6561281 chr13:46596601 C/T cg15192986 chr13:46630673 CPB2 -0.67 -9.81 -0.48 4.16e-20 Blood protein levels; CRC cis rs17023223 0.537 rs1325940 chr1:119586687 G/A cg05756136 chr1:119680316 WARS2 -0.47 -6.26 -0.33 1.2e-9 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for BMI in active individuals; CRC cis rs1799949 0.965 rs11080034 chr17:41443014 T/C cg05368731 chr17:41323189 NBR1 0.57 8.39 0.42 1.5e-15 Menopause (age at onset); CRC cis rs11719291 0.833 rs13074318 chr3:48816725 C/T cg07636037 chr3:49044803 WDR6 -0.81 -6.39 -0.33 5.65e-10 Cognitive function; CRC cis rs1728785 0.901 rs1103286 chr16:68578625 C/T cg02972257 chr16:68554789 NA -0.58 -7.24 -0.37 3.21e-12 Ulcerative colitis; CRC cis rs9372498 0.536 rs9489394 chr6:118758234 T/C cg24463073 chr6:118973353 C6orf204 0.52 6.83 0.35 4.24e-11 Diastolic blood pressure; CRC cis rs1799949 0.894 rs8176160 chr17:41241503 T/C cg23758822 chr17:41437982 NA 0.81 13.76 0.6 2.44e-34 Menopause (age at onset); CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg03732293 chr1:179335087 C1orf125 0.5 6.5 0.34 3.05e-10 Thyroid stimulating hormone; CRC cis rs2204008 0.640 rs2320744 chr12:38162389 A/G cg26384229 chr12:38710491 ALG10B 0.69 9.15 0.45 6.08e-18 Bladder cancer; CRC cis rs796364 1.000 rs281785 chr2:200749566 A/G cg25936922 chr2:200820526 C2orf60;C2orf47 0.72 8.02 0.4 1.87e-14 Schizophrenia; CRC cis rs34375054 0.738 rs10846834 chr12:125625570 A/G cg09839279 chr12:125627357 AACS -0.38 -5.76 -0.3 1.9e-8 Post bronchodilator FEV1/FVC ratio; CRC cis rs7703744 0.681 rs73239278 chr5:118695051 G/A cg23985447 chr5:118691066 TNFAIP8 0.43 6.04 0.32 4.11e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs9487051 0.844 rs9386792 chr6:109609975 G/A cg12927641 chr6:109611667 NA -0.38 -6.85 -0.35 3.7e-11 Reticulocyte fraction of red cells; CRC cis rs55794721 0.509 rs873308 chr1:25758655 A/G cg02931644 chr1:25747376 RHCE -0.33 -5.91 -0.31 8.75e-9 Plateletcrit;Mean corpuscular volume; CRC cis rs6582630 0.502 rs11520261 chr12:38332019 T/G cg13010199 chr12:38710504 ALG10B 0.47 6.53 0.34 2.47e-10 Drug-induced liver injury (flucloxacillin); CRC cis rs4742903 0.967 rs4742904 chr9:106856952 C/T cg14250997 chr9:106856677 SMC2 0.39 5.67 0.3 3.15e-8 High-grade serous ovarian cancer;Breast cancer; CRC cis rs116095464 0.558 rs2288458 chr5:231260 C/T cg22496380 chr5:211416 CCDC127 -0.86 -9.9 -0.48 2.13e-20 Breast cancer; CRC cis rs1218582 0.774 rs1007170 chr1:154881461 G/A cg16680214 chr1:154839983 KCNN3 -0.48 -9.35 -0.46 1.38e-18 Prostate cancer; CRC cis rs514406 0.505 rs146750 chr1:53183447 C/G cg08859206 chr1:53392774 SCP2 -0.4 -6.05 -0.32 4.02e-9 Monocyte count; CRC cis rs1881797 0.527 rs1852908 chr1:247678260 C/T cg18198730 chr1:247681584 NA 0.62 6.91 0.36 2.55e-11 Acute lymphoblastic leukemia (childhood); CRC cis rs769267 0.896 rs7250893 chr19:19625547 A/G cg03709012 chr19:19516395 GATAD2A 0.72 11.21 0.53 6.56e-25 Tonsillectomy; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg00926192 chr17:42297085 UBTF 0.36 6.11 0.32 2.82e-9 Liver disease severity in Alagille syndrome; CRC trans rs2018683 0.933 rs12536127 chr7:28985967 T/C cg19402173 chr7:128379420 CALU -0.57 -8.54 -0.43 5.02e-16 Response to irinotecan and platinum-based chemotherapy in non-small-cell lung cancer; CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg22062239 chr16:31106011 VKORC1 -0.52 -6.31 -0.33 9.05e-10 Diisocyanate-induced asthma; CRC trans rs7395662 0.591 rs4882138 chr11:48619321 A/G cg15704280 chr7:45808275 SEPT13 -0.49 -6.85 -0.35 3.64e-11 HDL cholesterol; CRC trans rs1814175 0.669 rs17472879 chr11:49499520 G/T cg11707556 chr5:10655725 ANKRD33B -0.36 -6.66 -0.34 1.12e-10 Height; CRC cis rs4862750 0.837 rs1863404 chr4:187874654 T/C cg27532560 chr4:187881888 NA -0.54 -10.04 -0.48 7.11e-21 Lobe attachment (rater-scored or self-reported); CRC cis rs12594515 1.000 rs8027000 chr15:45987795 T/C cg01629716 chr15:45996671 NA 0.41 8.46 0.42 9.03e-16 Waist circumference;Weight; CRC cis rs4629710 0.592 rs35017713 chr6:131581212 G/A cg12606694 chr6:131520996 AKAP7 0.58 8.63 0.43 2.69e-16 Multiple myeloma (IgH translocation); CRC cis rs6952808 1.000 rs6953693 chr7:1886388 C/G cg22963979 chr7:1858916 MAD1L1 -0.6 -9.51 -0.46 4.1e-19 Bipolar disorder and schizophrenia; CRC trans rs12599106 0.839 rs3853177 chr16:34498532 A/G cg01516881 chr6:292596 DUSP22 -0.57 -8.23 -0.41 4.48e-15 Menopause (age at onset); CRC cis rs10089 0.552 rs1351141 chr5:127550055 A/C cg25462716 chr5:127418816 SLC12A2;FLJ33630 -0.6 -7.71 -0.39 1.5e-13 Ileal carcinoids; CRC trans rs2303319 0.504 rs12463509 chr2:162347948 C/T cg04145477 chr6:107077629 RTN4IP1;QRSL1 -0.77 -6.04 -0.32 4.18e-9 Cognitive function; CRC cis rs7044106 0.708 rs2416760 chr9:123374639 T/C cg09419670 chr9:123605666 PSMD5;LOC253039 0.65 10.62 0.51 7.35e-23 Hip circumference adjusted for BMI; CRC trans rs1005277 0.579 rs1614236 chr10:38502996 C/T cg11292332 chr7:45801988 SEPT13 -0.38 -6.81 -0.35 4.75e-11 Extrinsic epigenetic age acceleration; CRC cis rs1552244 1.000 rs112847840 chr3:10101652 C/T cg08888203 chr3:10149979 C3orf24 0.73 10.16 0.49 2.86e-21 Alzheimer's disease; CRC trans rs12155874 0.774 rs13252664 chr8:13971870 C/T cg08330183 chr15:22892184 CYFIP1 0.45 6.28 0.33 1.06e-9 Intelligence (multi-trait analysis); CRC cis rs910187 0.678 rs3818013 chr20:45816639 A/G cg27589058 chr20:45804311 EYA2 -0.39 -7.51 -0.38 5.6e-13 Migraine; CRC cis rs1448094 0.511 rs10863071 chr12:86145813 A/G cg25456477 chr12:86230367 RASSF9 -0.35 -6.08 -0.32 3.39e-9 Major depressive disorder; CRC cis rs9398803 0.830 rs9401885 chr6:126825837 C/G cg19875578 chr6:126661172 C6orf173 0.42 5.86 0.31 1.15e-8 Male-pattern baldness; CRC cis rs2976388 0.609 rs2585148 chr8:143796193 C/G cg24046110 chr8:143859143 LYNX1 0.47 8.18 0.41 6.48e-15 Urinary tract infection frequency; CRC cis rs1728785 1.000 rs1170431 chr16:68605639 T/C cg02972257 chr16:68554789 NA -0.6 -7.52 -0.38 5.1e-13 Ulcerative colitis; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg07698384 chr15:25684465 UBE3A 0.49 6.9 0.36 2.7e-11 Response to antipsychotic treatment; CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg01363902 chr12:121022439 NA -0.51 -6.39 -0.33 5.58e-10 Diisocyanate-induced asthma; CRC cis rs2073300 0.609 rs6137927 chr20:23372513 A/G cg12062639 chr20:23401060 NAPB 0.74 6.78 0.35 5.43e-11 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs8060686 0.858 rs11553287 chr16:67905407 A/G cg07125278 chr16:67683757 RLTPR -0.49 -6.81 -0.35 4.54e-11 HDL cholesterol;Metabolic syndrome; CRC trans rs116095464 0.614 rs28736753 chr5:274081 G/A cg00938859 chr5:1591904 SDHAP3 0.71 7.59 0.39 3.23e-13 Breast cancer; CRC cis rs13256369 1.000 rs4840352 chr8:8573508 A/G cg18904891 chr8:8559673 CLDN23 0.5 6.62 0.34 1.45e-10 Obesity-related traits; CRC cis rs9915657 0.933 rs4793272 chr17:70139257 A/T cg09344028 chr17:70110421 NA 0.49 7.78 0.39 9.37e-14 Thyroid hormone levels; CRC cis rs514406 0.825 rs7523761 chr1:53250915 T/C cg25767906 chr1:53392781 SCP2 0.4 6.53 0.34 2.55e-10 Monocyte count; CRC trans rs4332037 0.851 rs1403175 chr7:1964357 A/T cg11693508 chr17:37793320 STARD3 -0.61 -7.5 -0.38 6.14e-13 Bipolar disorder; CRC cis rs6499255 1.000 rs55863174 chr16:69819996 G/C cg04110750 chr16:69646130 NFAT5 -0.54 -7.12 -0.37 6.73e-12 IgE levels; CRC trans rs7618501 1.000 rs7649348 chr3:49772375 G/A cg21659725 chr3:3221576 CRBN -0.9 -17.3 -0.69 3.95e-48 Intelligence (multi-trait analysis); CRC cis rs11645898 0.687 rs56129242 chr16:72098260 C/G cg14768367 chr16:72042858 DHODH -0.55 -6.1 -0.32 3.01e-9 Blood protein levels; CRC cis rs9388451 0.626 rs1343116 chr6:126069702 C/A cg05901451 chr6:126070800 HEY2 -0.54 -9.01 -0.44 1.69e-17 Brugada syndrome; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg09423085 chr2:68478351 PPP3R1 0.41 6.12 0.32 2.63e-9 Liver disease severity in Alagille syndrome; CRC cis rs55871839 0.684 rs10108037 chr8:59812337 A/C cg07426533 chr8:59803705 TOX -0.34 -5.94 -0.31 7.22e-9 Pneumonia; CRC cis rs6662572 0.737 rs111970066 chr1:46572817 C/T cg03123370 chr1:45965343 CCDC163P;MMACHC 0.49 6.38 0.33 6.09e-10 Blood protein levels; CRC cis rs6121246 0.909 rs6089058 chr20:30326338 T/G cg13852791 chr20:30311386 BCL2L1 0.67 10.95 0.52 5.48e-24 Mean corpuscular hemoglobin; CRC cis rs10413329 1.000 rs10403210 chr19:13103638 C/T cg13338734 chr19:13113668 NFIX -0.33 -5.69 -0.3 2.78e-8 Intelligence (multi-trait analysis); CRC cis rs738322 0.555 rs5750549 chr22:38547172 C/T cg25457927 chr22:38595422 NA -0.37 -7.53 -0.38 5.01e-13 Cutaneous nevi; CRC cis rs3026101 0.671 rs2285746 chr17:5311742 C/T cg25236894 chr17:5323110 RPAIN;NUP88 0.42 6.9 0.36 2.74e-11 Body mass index; CRC cis rs13108904 0.935 rs1620928 chr4:1279124 C/T cg05665937 chr4:1216051 CTBP1 -0.39 -5.87 -0.31 1.06e-8 Obesity-related traits; CRC cis rs6502050 0.835 rs6502059 chr17:80082886 T/C cg25804541 chr17:80189381 SLC16A3 0.31 5.9 0.31 8.94e-9 Life satisfaction; CRC cis rs907683 0.584 rs12920 chr2:220285666 C/G cg15015639 chr2:220282977 DES 0.4 6.72 0.35 7.82e-11 Resting heart rate; CRC cis rs10779751 0.762 rs6671083 chr1:11325910 A/G cg08854313 chr1:11322531 MTOR -0.47 -6.8 -0.35 4.81e-11 Body mass index; CRC trans rs11026407 0.967 rs7127246 chr11:22060228 C/G cg00393283 chr10:92984646 PCGF5 -0.58 -6.62 -0.34 1.49e-10 Plasma thyroid-stimulating hormone levels; CRC cis rs6674176 0.593 rs6675620 chr1:44417630 C/T cg12908607 chr1:44402522 ARTN -0.51 -9.1 -0.45 8.85e-18 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Cognitive ability; CRC cis rs7927771 0.832 rs11601173 chr11:47401058 A/G cg18512352 chr11:47633146 NA -0.35 -6.84 -0.35 3.98e-11 Subjective well-being; CRC cis rs2228479 0.867 rs2270459 chr16:89979851 A/C cg06656553 chr16:89960601 TCF25 0.54 5.71 0.3 2.49e-8 Skin colour saturation; CRC cis rs10504229 0.683 rs6999351 chr8:58127227 C/T cg02725872 chr8:58115012 NA -0.64 -11.55 -0.54 3.85e-26 Developmental language disorder (linguistic errors); CRC cis rs559928 0.606 rs11231710 chr11:63925743 A/G cg19465662 chr11:63993652 NUDT22;TRPT1 0.7 6.7 0.35 8.83e-11 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; CRC cis rs6728302 0.557 rs7600132 chr2:233248198 C/A cg09490371 chr2:233253024 ECEL1P2 -0.72 -6.37 -0.33 6.5e-10 Height; CRC cis rs12701220 0.542 rs6957866 chr7:1111674 G/A cg26769984 chr7:1090371 C7orf50 0.54 6.96 0.36 1.84e-11 Bronchopulmonary dysplasia; CRC cis rs9611565 0.659 rs9611609 chr22:41945357 C/A cg17554472 chr22:41940697 POLR3H -0.57 -6.08 -0.32 3.28e-9 Vitiligo; CRC cis rs60871478 0.636 rs6976929 chr7:901382 C/T cg05535760 chr7:792225 HEATR2 -0.9 -9.96 -0.48 1.36e-20 Cerebrospinal P-tau181p levels; CRC cis rs7605827 0.930 rs1469016 chr2:15687627 A/G cg19274914 chr2:15703543 NA 0.39 5.82 0.31 1.4e-8 Educational attainment (years of education); CRC cis rs9325144 0.560 rs11183150 chr12:38674698 A/G cg26384229 chr12:38710491 ALG10B -0.55 -8.21 -0.41 5.02e-15 Morning vs. evening chronotype; CRC cis rs11098499 0.863 rs1552092 chr4:120488496 C/T cg24375607 chr4:120327624 NA 0.48 7.19 0.37 4.29e-12 Corneal astigmatism; CRC cis rs514406 0.861 rs505444 chr1:53251860 C/T cg24675658 chr1:53192096 ZYG11B -0.56 -8.13 -0.41 8.96e-15 Monocyte count; CRC cis rs853679 0.546 rs200989 chr6:27816442 A/G cg23259851 chr6:27775964 HIST1H2AI;HIST1H2BL 0.71 5.92 0.31 8.04e-9 Depression; CRC cis rs2153535 0.601 rs2143353 chr6:8530111 T/G cg07606381 chr6:8435919 SLC35B3 0.67 10.85 0.51 1.15e-23 Motion sickness; CRC cis rs12753569 0.748 rs1013629 chr1:76513759 A/G cg00791851 chr1:76518896 NA 0.37 6.87 0.35 3.18e-11 Personality dimensions; CRC cis rs9287719 0.967 rs6432122 chr2:10753844 A/G cg00105475 chr2:10696890 NA 0.45 7.17 0.37 4.85e-12 Prostate cancer; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg18452880 chr6:170151829 C6orf70;TCTE3 0.42 6.83 0.35 4.01e-11 Liver disease severity in Alagille syndrome; CRC cis rs780096 0.546 rs7563162 chr2:27631191 C/T cg21248554 chr2:27665150 KRTCAP3 -0.32 -7.41 -0.38 1.05e-12 Total body bone mineral density; CRC cis rs1799949 1.000 rs11654731 chr17:41326940 G/A cg01879757 chr17:41196368 BRCA1 -0.41 -6.18 -0.32 1.86e-9 Menopause (age at onset); CRC cis rs7917772 0.560 rs10786697 chr10:104378563 G/T cg11453585 chr10:104263688 ACTR1A;SUFU 0.81 14.64 0.63 9.85e-38 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC cis rs17023223 0.537 rs10802075 chr1:119627227 C/T cg05756136 chr1:119680316 WARS2 -0.51 -6.87 -0.35 3.32e-11 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for BMI in active individuals; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg13837895 chr19:50145301 SCAF1 0.46 6.38 0.33 6.06e-10 Response to antipsychotic treatment; CRC cis rs875971 1.000 rs4717292 chr7:65895598 G/A cg18912574 chr7:65842487 NCRNA00174 0.36 6.1 0.32 2.97e-9 Aortic root size; CRC cis rs7552404 0.924 rs7535991 chr1:76162624 C/T cg03433033 chr1:76189801 ACADM 0.92 14.18 0.62 5.85e-36 Blood metabolite levels;Acylcarnitine levels; CRC cis rs1832871 0.711 rs12527510 chr6:158657299 T/G cg07165851 chr6:158734300 TULP4 0.58 7.19 0.37 4.51e-12 Height; CRC cis rs7666738 0.830 rs2903152 chr4:99067992 A/G cg17366294 chr4:99064904 C4orf37 0.43 7.32 0.37 1.87e-12 Colonoscopy-negative controls vs population controls; CRC cis rs12580194 0.593 rs4448777 chr12:55724981 T/C cg23425280 chr12:56401806 NA 0.48 5.81 0.31 1.45e-8 Cancer; CRC cis rs4664293 0.899 rs7588710 chr2:160529522 T/A cg08347373 chr2:160653686 CD302 -0.46 -7.36 -0.38 1.51e-12 Monocyte percentage of white cells; CRC cis rs2288912 0.808 rs35670684 chr19:45455985 A/C cg13119609 chr19:45449297 APOC2 0.31 5.76 0.3 1.92e-8 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs669446 0.528 rs4660743 chr1:44195404 C/T cg12908607 chr1:44402522 ARTN -0.33 -5.7 -0.3 2.72e-8 Amyotrophic lateral sclerosis (age of onset); CRC cis rs10888329 0.720 rs4428922 chr1:248406894 C/T cg00666640 chr1:248458726 OR2T12 0.4 6.79 0.35 5.19e-11 Autism spectrum disorder; CRC cis rs10504229 0.683 rs7838958 chr8:58136968 T/C cg02725872 chr8:58115012 NA -0.64 -11.55 -0.54 3.85e-26 Developmental language disorder (linguistic errors); CRC cis rs10504229 1.000 rs67243305 chr8:58174958 G/A cg02725872 chr8:58115012 NA -0.37 -6.25 -0.33 1.24e-9 Developmental language disorder (linguistic errors); CRC cis rs838147 0.534 rs2638280 chr19:49209318 G/A cg21064579 chr19:49206444 FUT2 0.5 8.73 0.43 1.28e-16 Dietary macronutrient intake; CRC cis rs10791097 0.694 rs4937581 chr11:130740335 T/C cg12179176 chr11:130786555 SNX19 0.75 12.76 0.58 1.4e-30 Autism spectrum disorder or schizophrenia;Schizophrenia; CRC cis rs7246657 0.765 rs7247259 chr19:37851090 T/C cg23950597 chr19:37808831 NA -0.47 -5.76 -0.3 1.94e-8 Coronary artery calcification; CRC cis rs2073499 1.000 rs1989839 chr3:50378946 A/G cg08207895 chr3:50388901 TUSC4;CYB561D2 0.58 6.27 0.33 1.12e-9 Schizophrenia; CRC cis rs7208859 0.673 rs9895684 chr17:29242600 G/A cg13385521 chr17:29058706 SUZ12P 0.69 8.04 0.41 1.64e-14 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs1046896 0.731 rs8067667 chr17:80785875 A/G cg02711726 chr17:80685570 FN3KRP -0.55 -7.4 -0.38 1.15e-12 Glycated hemoglobin levels; CRC cis rs7772486 0.641 rs9390370 chr6:146357569 C/T cg13319975 chr6:146136371 FBXO30 -0.53 -7.38 -0.38 1.34e-12 Lobe attachment (rater-scored or self-reported); CRC trans rs1997103 1.000 rs10224446 chr7:55413147 C/G cg20935933 chr6:143382018 AIG1 0.5 6.46 0.34 3.66e-10 QRS interval (sulfonylurea treatment interaction); CRC cis rs4803455 0.565 rs11083616 chr19:41865643 A/G cg08477640 chr19:41863820 B9D2 -0.5 -7.88 -0.4 4.97e-14 Migraine;Coronary artery disease; CRC cis rs965469 1.000 rs6139088 chr20:3329063 G/A cg25506879 chr20:3388711 C20orf194 -0.37 -5.6 -0.3 4.41e-8 IFN-related cytopenia; CRC cis rs950169 0.840 rs4842854 chr15:84942339 T/G cg17507749 chr15:85114479 UBE2QP1 0.74 10.59 0.5 9.91e-23 Schizophrenia; CRC cis rs7208859 0.673 rs9912122 chr17:29140716 C/A cg13385521 chr17:29058706 SUZ12P 0.57 7.29 0.37 2.29e-12 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs6502050 0.731 rs34796376 chr17:80116635 G/T cg25804541 chr17:80189381 SLC16A3 -0.31 -6.06 -0.32 3.74e-9 Life satisfaction; CRC cis rs2949837 0.528 rs10260816 chr7:46010100 C/G cg15898840 chr7:45960834 IGFBP3 -0.49 -7.82 -0.4 7.33e-14 Sitting height ratio; CRC cis rs7605827 0.930 rs10208972 chr2:15676686 G/A cg19274914 chr2:15703543 NA 0.39 5.83 0.31 1.33e-8 Educational attainment (years of education); CRC cis rs8114671 0.804 rs6088666 chr20:33564570 A/G cg07148914 chr20:33460835 GGT7 0.36 5.68 0.3 2.89e-8 Height; CRC cis rs367615 0.552 rs2115511 chr5:108725403 A/T cg17395555 chr5:108820864 NA -0.34 -6.68 -0.35 1.04e-10 Colorectal cancer (SNP x SNP interaction); CRC cis rs6840360 0.582 rs11733820 chr4:152316139 T/C cg09659197 chr4:152720779 NA 0.33 6.34 0.33 7.38e-10 Intelligence (multi-trait analysis); CRC cis rs12282928 1.000 rs6485822 chr11:48292801 C/G cg20307385 chr11:47447363 PSMC3 0.48 6.02 0.31 4.66e-9 Migraine - clinic-based; CRC trans rs11039798 0.544 rs114343057 chr11:48558172 C/T cg03929089 chr4:120376271 NA 0.65 6.72 0.35 8.24e-11 Axial length; CRC cis rs6964587 0.626 rs404 chr7:91544316 G/T cg17063962 chr7:91808500 NA -0.58 -9.23 -0.45 3.3e-18 Breast cancer; CRC cis rs377457 0.856 rs11117268 chr16:85738269 A/T cg02758499 chr16:85682440 KIAA0182 0.33 5.88 0.31 9.83e-9 Type 2 diabetes; CRC cis rs2239547 0.657 rs4687672 chr3:52880543 G/A cg10802521 chr3:52805072 NEK4 -0.46 -6.18 -0.32 1.93e-9 Schizophrenia; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg13051058 chr15:34629706 SLC12A6 0.46 6.69 0.35 9.87e-11 Intelligence (multi-trait analysis); CRC cis rs881375 0.934 rs2159778 chr9:123678129 G/A cg09419670 chr9:123605666 PSMD5;LOC253039 0.6 9.41 0.46 9.13e-19 Rheumatoid arthritis; CRC cis rs10883723 0.773 rs2296587 chr10:104245588 G/A cg22532475 chr10:104410764 TRIM8 -0.4 -6.78 -0.35 5.67e-11 Allergic disease (asthma, hay fever or eczema); CRC cis rs6088580 0.634 rs6058051 chr20:33044862 G/A cg24642439 chr20:33292090 TP53INP2 0.37 6.23 0.32 1.41e-9 Glomerular filtration rate (creatinine); CRC cis rs8180040 0.676 rs11130114 chr3:47154651 T/G cg10298567 chr3:47292165 KIF9 -0.38 -6.24 -0.33 1.35e-9 Colorectal cancer; CRC cis rs9291683 0.632 rs10939669 chr4:10045827 A/G cg00071950 chr4:10020882 SLC2A9 0.67 12.67 0.57 3.14e-30 Bone mineral density; CRC cis rs3849570 0.533 rs4440144 chr3:81988359 A/G cg07356753 chr3:81810745 GBE1 -0.46 -6.34 -0.33 7.76e-10 Waist circumference;Body mass index; CRC cis rs7647973 1.000 rs11928090 chr3:49604904 G/A cg07636037 chr3:49044803 WDR6 0.65 8.03 0.4 1.72e-14 Menarche (age at onset); CRC trans rs11039798 1.000 rs12281162 chr11:48650491 T/C cg03929089 chr4:120376271 NA 0.64 6.22 0.32 1.53e-9 Axial length; CRC cis rs2153535 0.580 rs1577470 chr6:8462426 G/A cg07606381 chr6:8435919 SLC35B3 0.67 10.71 0.51 3.63e-23 Motion sickness; CRC cis rs6952808 0.531 rs3778998 chr7:2180753 C/A cg21782813 chr7:2030301 MAD1L1 0.44 7.75 0.39 1.16e-13 Bipolar disorder and schizophrenia; CRC cis rs7811142 0.943 rs111757992 chr7:100016354 A/C cg00814883 chr7:100076585 TSC22D4 -0.72 -9.39 -0.46 1.02e-18 Platelet count; CRC cis rs2153535 0.580 rs9328486 chr6:8528008 T/C cg07606381 chr6:8435919 SLC35B3 0.67 10.85 0.51 1.15e-23 Motion sickness; CRC cis rs11628318 0.660 rs35258120 chr14:103058769 G/A cg12046867 chr14:103022105 NA -0.7 -8.69 -0.43 1.71e-16 Platelet count; CRC cis rs11148252 1.000 rs11148252 chr13:53009048 C/T cg12458913 chr13:53173898 NA 0.51 8.14 0.41 8.49e-15 Lewy body disease; CRC cis rs2153535 0.580 rs7742689 chr6:8452433 C/A cg07606381 chr6:8435919 SLC35B3 0.68 10.85 0.51 1.2e-23 Motion sickness; CRC cis rs951366 0.903 rs823116 chr1:205720483 G/A cg11965913 chr1:205819406 PM20D1 0.45 6.87 0.35 3.14e-11 Menarche (age at onset); CRC cis rs2976388 1.000 rs2920297 chr8:143763083 A/G cg04969067 chr8:143858791 LYNX1 -0.34 -5.82 -0.31 1.38e-8 Urinary tract infection frequency; CRC cis rs10924970 0.967 rs1933246 chr1:235391446 T/C cg26050004 chr1:235667680 B3GALNT2 0.39 5.79 0.3 1.64e-8 Asthma; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg11151929 chr3:120068323 LRRC58 0.47 6.15 0.32 2.25e-9 Thyroid stimulating hormone; CRC cis rs28489187 0.706 rs4949890 chr1:85830632 T/C cg17737388 chr1:85724454 C1orf52 0.38 5.7 0.3 2.67e-8 Asymmetrical dimethylarginine levels;Serum dimethylarginine levels (asymmetric/symetric ratio); CRC cis rs9399135 0.933 rs41294852 chr6:135376379 T/G cg22676075 chr6:135203613 NA 0.38 5.95 0.31 6.75e-9 Red blood cell count; CRC cis rs877282 0.838 rs34912955 chr10:772222 T/C cg17470449 chr10:769945 NA 0.63 8.43 0.42 1.11e-15 Uric acid levels; CRC cis rs7552404 0.924 rs12136754 chr1:76230232 C/A cg10523679 chr1:76189770 ACADM 0.94 14.39 0.62 9.68e-37 Blood metabolite levels;Acylcarnitine levels; CRC cis rs9902453 0.904 rs12948898 chr17:28410324 G/A cg26525008 chr17:28256777 EFCAB5;SSH2 -0.73 -12.33 -0.56 5.77e-29 Coffee consumption (cups per day); CRC cis rs4660261 0.526 rs3094954 chr1:44320919 C/T cg12908607 chr1:44402522 ARTN -0.53 -9.51 -0.46 4.11e-19 Intelligence (multi-trait analysis); CRC cis rs1448094 0.512 rs7313278 chr12:86250263 C/T cg00310523 chr12:86230176 RASSF9 0.35 5.93 0.31 7.63e-9 Major depressive disorder; CRC cis rs4808199 0.895 rs10403731 chr19:19469296 G/A cg03709012 chr19:19516395 GATAD2A 0.9 11.06 0.52 2.16e-24 Nonalcoholic fatty liver disease; CRC cis rs9398803 0.865 rs2050644 chr6:126805255 A/G cg19875578 chr6:126661172 C6orf173 0.42 5.86 0.31 1.15e-8 Male-pattern baldness; CRC cis rs4285028 0.948 rs76593525 chr3:121690477 G/A cg11130432 chr3:121712080 ILDR1 -0.52 -6.76 -0.35 6.37e-11 Multiple sclerosis; CRC cis rs2075371 1.000 rs432487 chr7:133990114 T/G cg11752832 chr7:134001865 SLC35B4 0.5 7.75 0.39 1.19e-13 Mean platelet volume; CRC cis rs2115630 0.645 rs2292463 chr15:85175750 A/G cg09876464 chr15:85330779 ZNF592 0.39 6.54 0.34 2.32e-10 P wave terminal force; CRC trans rs916888 0.821 rs199514 chr17:44856881 G/A cg01341218 chr17:43662625 NA -0.84 -9.3 -0.46 2.06e-18 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs9291683 0.609 rs12500810 chr4:10031068 G/A cg11266682 chr4:10021025 SLC2A9 0.53 11.26 0.53 4.14e-25 Bone mineral density; CRC trans rs1005277 0.563 rs2800550 chr10:38482929 T/C cg23533926 chr12:111358616 MYL2 -0.54 -8.21 -0.41 5e-15 Extrinsic epigenetic age acceleration; CRC cis rs9309473 0.948 rs11884776 chr2:73746923 C/T cg20560298 chr2:73613845 ALMS1 -0.5 -6.16 -0.32 2.13e-9 Metabolite levels; CRC cis rs2839186 0.619 rs2187118 chr21:47611310 C/T cg13126279 chr21:47581558 C21orf56 -0.36 -5.65 -0.3 3.55e-8 Testicular germ cell tumor; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg08874598 chr8:102217901 ZNF706 0.41 7.41 0.38 1.06e-12 Liver disease severity in Alagille syndrome; CRC cis rs3785574 0.962 rs2665840 chr17:61873307 C/T cg06873352 chr17:61820015 STRADA -0.49 -7.86 -0.4 5.5e-14 Height; CRC cis rs950169 0.845 rs4106951 chr15:84833394 C/G cg17507749 chr15:85114479 UBE2QP1 0.75 11.04 0.52 2.5300000000000002e-24 Schizophrenia; CRC cis rs9303401 0.659 rs12944971 chr17:56988801 A/T cg02118635 chr17:56770003 RAD51C;TEX14 0.82 9.86 0.48 2.8e-20 Cognitive test performance; CRC cis rs7762018 0.607 rs75010113 chr6:170057441 C/T cg24289452 chr6:170231220 NA -0.81 -7.18 -0.37 4.55e-12 Thiazide-induced adverse metabolic effects in hypertensive patients; CRC cis rs58688157 0.705 rs11539530 chr11:609353 G/A cg16486109 chr11:613632 IRF7 0.73 12.38 0.56 3.58e-29 Systemic lupus erythematosus; CRC trans rs1814175 0.817 rs28525029 chr11:50045815 A/G cg11707556 chr5:10655725 ANKRD33B -0.43 -8.37 -0.42 1.72e-15 Height; CRC cis rs3736485 0.844 rs12593979 chr15:51741579 A/G cg08986416 chr15:51914746 DMXL2 0.44 6.4 0.33 5.23e-10 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs7731657 0.537 rs6867710 chr5:130201260 A/C cg08523029 chr5:130500466 HINT1 -0.46 -5.86 -0.31 1.11e-8 Fasting plasma glucose; CRC trans rs559356 0.519 rs604721 chr3:34839735 T/C cg18960307 chr17:4699574 PSMB6 0.41 6.06 0.32 3.72e-9 Cognitive function; CRC cis rs3099143 1.000 rs7178759 chr15:77143513 A/G cg21673338 chr15:77095150 SCAPER 0.53 6.01 0.31 4.81e-9 Recalcitrant atopic dermatitis; CRC cis rs9435341 0.965 rs55909997 chr1:107581039 G/A cg14828511 chr1:107599125 PRMT6 0.55 7.5 0.38 5.91e-13 Facial morphology (factor 21, depth of nasal alae); CRC cis rs832540 0.931 rs832535 chr5:56213334 C/T cg20203395 chr5:56204925 C5orf35 -0.41 -5.83 -0.31 1.35e-8 Coronary artery disease; CRC cis rs1403694 0.515 rs822362 chr3:186453065 A/C cg04611788 chr3:186434169 KNG1 -0.58 -8.32 -0.42 2.31e-15 Blood protein levels; CRC cis rs736801 0.780 rs2188962 chr5:131770805 C/T cg11843238 chr5:131593191 PDLIM4 0.33 5.69 0.3 2.87e-8 Breast cancer;Mosquito bite size; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg16092991 chr4:15004611 CPEB2 0.45 6.53 0.34 2.43e-10 Response to antipsychotic treatment; CRC cis rs7493 0.755 rs116306774 chr7:95016976 G/A cg19678392 chr7:94953810 PON1 -0.55 -6.72 -0.35 8.11e-11 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs12477438 0.765 rs62154638 chr2:99639584 C/T cg14399236 chr2:99771627 LIPT1;TSGA10 -0.6 -8.2 -0.41 5.41e-15 Chronic sinus infection; CRC cis rs12545109 0.876 rs4738494 chr8:57327438 G/T cg09654669 chr8:57350985 NA -0.45 -6.56 -0.34 2.12e-10 Obesity-related traits; CRC cis rs9788333 0.762 rs4441120 chr13:21886863 T/A cg06138931 chr13:21896616 NA 0.58 9.45 0.46 6.54e-19 Thiazide-induced adverse metabolic effects in hypertensive patients; CRC cis rs7927771 0.832 rs11601603 chr11:47401171 A/C cg18512352 chr11:47633146 NA -0.35 -6.84 -0.35 3.98e-11 Subjective well-being; CRC cis rs853679 0.542 rs6934769 chr6:28090931 A/G cg21251018 chr6:28226885 NKAPL 0.48 6.33 0.33 7.86e-10 Depression; CRC cis rs6460942 0.630 rs62451487 chr7:12390464 G/A cg20607287 chr7:12443886 VWDE -0.55 -5.89 -0.31 9.31e-9 Coronary artery disease; CRC cis rs7811142 0.830 rs28495773 chr7:99943583 A/T cg00814883 chr7:100076585 TSC22D4 -0.73 -8.64 -0.43 2.45e-16 Platelet count; CRC cis rs2019137 0.560 rs11123172 chr2:113984303 C/T cg19083407 chr2:113993142 PAX8;LOC440839;LOC654433 -0.58 -8.78 -0.44 9.2e-17 Lymphocyte counts; CRC cis rs270601 0.739 rs3900945 chr5:131592870 T/C cg09877947 chr5:131593287 PDLIM4 0.55 10.25 0.49 1.41e-21 Acylcarnitine levels; CRC cis rs1035144 0.505 rs6574617 chr14:81457615 G/A cg06600135 chr14:81408086 NA -0.54 -8.25 -0.41 3.85e-15 Male sexual orientation; CRC cis rs950169 0.887 rs12903946 chr15:84954430 T/C cg11189052 chr15:85197271 WDR73 0.63 8.8 0.44 7.65e-17 Schizophrenia; CRC cis rs2180341 0.960 rs7756884 chr6:127684018 A/G cg27446573 chr6:127587934 RNF146 0.97 13.77 0.6 2.17e-34 Breast cancer; CRC cis rs736408 0.812 rs2240920 chr3:52831009 A/G cg18404041 chr3:52824283 ITIH1 0.45 8.95 0.44 2.73e-17 Bipolar disorder; CRC cis rs11252926 0.831 rs816570 chr10:680475 C/T cg18196295 chr10:418757 DIP2C -0.42 -5.75 -0.3 2.01e-8 Psychosis in Alzheimer's disease; CRC cis rs9926296 0.533 rs12102290 chr16:89812617 C/T cg04287289 chr16:89883240 FANCA 0.8 14.0 0.61 3.05e-35 Vitiligo; CRC cis rs28386778 0.897 rs2859619 chr17:61917686 T/C cg22520471 chr17:61851767 DDX42;CCDC47 0.75 11.67 0.54 1.44e-26 Prudent dietary pattern; CRC cis rs9649213 0.593 rs6947208 chr7:97912204 C/T cg21770322 chr7:97807741 LMTK2 0.54 9.09 0.45 9.85e-18 Prostate cancer (SNP x SNP interaction); CRC cis rs477692 0.935 rs568918 chr10:131414455 A/G cg05714579 chr10:131428358 MGMT 0.57 8.31 0.42 2.63e-15 Response to temozolomide; CRC cis rs4862750 0.914 rs9998558 chr4:187874691 A/G cg11301795 chr4:187892539 NA -0.83 -18.47 -0.71 8.93e-53 Lobe attachment (rater-scored or self-reported); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg17200204 chr3:43732323 ABHD5 0.4 6.12 0.32 2.68e-9 Liver disease severity in Alagille syndrome; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg00552226 chr2:70475288 TIA1 0.48 6.87 0.35 3.24e-11 Response to antipsychotic treatment; CRC cis rs1448094 0.522 rs12313658 chr12:86271063 C/T cg02569458 chr12:86230093 RASSF9 0.41 6.96 0.36 1.86e-11 Major depressive disorder; CRC cis rs7772486 0.875 rs6913797 chr6:146413758 A/G cg23711669 chr6:146136114 FBXO30 0.63 10.72 0.51 3.39e-23 Lobe attachment (rater-scored or self-reported); CRC cis rs2303759 0.709 rs3760667 chr19:49814832 C/T cg22133161 chr19:49891603 CCDC155 0.5 6.43 0.33 4.39e-10 Multiple sclerosis; CRC cis rs9911578 1.000 rs9911578 chr17:56953147 C/T cg05425664 chr17:57184151 TRIM37 -0.49 -7.77 -0.39 9.89e-14 Intelligence (multi-trait analysis); CRC cis rs10927875 0.793 rs1763619 chr1:16326935 A/G cg22431228 chr1:16359049 CLCNKA -0.39 -6.88 -0.35 2.96e-11 Dilated cardiomyopathy; CRC cis rs4713118 0.513 rs149975 chr6:27986340 G/A cg25164649 chr6:28176230 NA 0.63 9.02 0.45 1.62e-17 Parkinson's disease; CRC cis rs780096 0.526 rs1647276 chr2:27688601 C/T cg21248554 chr2:27665150 KRTCAP3 -0.33 -7.82 -0.4 7.44e-14 Total body bone mineral density; CRC cis rs6502050 0.835 rs6502079 chr17:80124454 T/A cg25804541 chr17:80189381 SLC16A3 -0.31 -5.95 -0.31 6.84e-9 Life satisfaction; CRC cis rs9329289 0.510 rs12356215 chr10:2545390 C/G cg15501526 chr10:2543763 NA 0.54 10.01 0.48 9.16e-21 Age-related hearing impairment; CRC cis rs2228479 0.717 rs62052210 chr16:89980158 A/G cg12064134 chr16:90016061 DEF8 -0.56 -5.78 -0.3 1.78e-8 Skin colour saturation; CRC cis rs6570726 0.846 rs6919684 chr6:145883801 A/G cg23711669 chr6:146136114 FBXO30 0.68 11.44 0.53 9.63e-26 Lobe attachment (rater-scored or self-reported); CRC cis rs629535 0.814 rs571682 chr8:70062793 A/G cg26132723 chr8:70041827 NA 0.34 5.69 0.3 2.82e-8 Dupuytren's disease; CRC cis rs8130944 0.859 rs35729571 chr21:44110493 T/C cg23590273 chr21:44105265 PDE9A -0.35 -5.62 -0.3 3.99e-8 Perceived unattractiveness to mosquitoes; CRC cis rs9942416 0.660 rs17649055 chr5:74984269 C/T cg00601450 chr5:74908170 NA 0.44 6.22 0.32 1.48e-9 Age-related disease endophenotypes; CRC cis rs7224685 0.501 rs4790169 chr17:4022665 G/A cg09695851 chr17:3907499 NA -0.78 -14.11 -0.61 1.13e-35 Type 2 diabetes; CRC cis rs9435341 0.965 rs55924375 chr1:107566690 C/A cg11070056 chr1:107600091 PRMT6 0.38 5.62 0.3 4.13e-8 Facial morphology (factor 21, depth of nasal alae); CRC cis rs9378357 0.850 rs9392474 chr6:3293731 G/A cg08754725 chr6:3293098 SLC22A23 -0.75 -6.9 -0.36 2.74e-11 Obesity-related traits; CRC cis rs2075371 0.734 rs13225086 chr7:134011411 C/T cg20476274 chr7:133979776 SLC35B4 0.61 9.46 0.46 6.17e-19 Mean platelet volume; CRC cis rs250677 1.000 rs36080 chr5:148430451 A/G cg23229984 chr5:148520753 ABLIM3 0.48 6.84 0.35 3.94e-11 Breast cancer; CRC cis rs10779751 1.000 rs12032364 chr1:11286872 G/T cg08854313 chr1:11322531 MTOR 0.66 9.33 0.46 1.6e-18 Body mass index; CRC cis rs10504229 0.679 rs11786328 chr8:58039269 A/G cg02290350 chr8:58132656 NA -0.55 -6.35 -0.33 7.04e-10 Developmental language disorder (linguistic errors); CRC cis rs311392 0.902 rs448238 chr8:55093655 C/T cg06042504 chr8:55087323 NA 0.41 6.61 0.34 1.55e-10 Pelvic organ prolapse (moderate/severe); CRC cis rs4819052 0.851 rs2838842 chr21:46669217 C/T cg11663144 chr21:46675770 NA -0.81 -14.3 -0.62 2.04e-36 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg25553015 chr19:39109861 MAP4K1;EIF3K 0.49 6.21 0.32 1.57e-9 Thyroid stimulating hormone; CRC cis rs7833790 0.724 rs72603871 chr8:82754460 C/G cg17211192 chr8:82754475 SNX16 0.47 6.62 0.34 1.47e-10 Diastolic blood pressure; CRC cis rs13108904 0.650 rs3796618 chr4:1349602 T/A cg02018176 chr4:1364513 KIAA1530 0.47 7.93 0.4 3.35e-14 Obesity-related traits; CRC cis rs40363 0.723 rs2736 chr16:3536872 G/A cg21433313 chr16:3507492 NAT15 -0.68 -6.59 -0.34 1.77e-10 Tuberculosis; CRC cis rs728616 0.867 rs12412226 chr10:81735288 C/T cg05935833 chr10:81318306 SFTPA2 -0.76 -8.28 -0.42 3.12e-15 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs10752881 0.967 rs6695837 chr1:182991462 T/C ch.1.3577855R chr1:183094577 LAMC1 0.86 15.17 0.64 8.93e-40 Colorectal cancer; CRC cis rs2228479 0.867 rs76885005 chr16:89966668 A/G cg06558623 chr16:89946397 TCF25 1.05 11.41 0.53 1.21e-25 Skin colour saturation; CRC cis rs473651 0.904 rs472247 chr2:239362573 G/A cg18131467 chr2:239335373 ASB1 0.98 21.08 0.76 5.11e-63 Multiple system atrophy; CRC cis rs709400 0.628 rs11621510 chr14:103869620 T/C cg01849466 chr14:104193079 ZFYVE21 0.39 5.64 0.3 3.71e-8 Body mass index; CRC cis rs3862030 0.503 rs6584506 chr10:104254428 T/C cg22532475 chr10:104410764 TRIM8 -0.37 -6.86 -0.35 3.51e-11 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for body mass index; CRC trans rs7937682 1.000 rs12363179 chr11:111568091 G/A cg18187862 chr3:45730750 SACM1L -0.53 -7.36 -0.38 1.48e-12 Primary sclerosing cholangitis; CRC cis rs12908161 0.960 rs62019463 chr15:85288087 G/A cg11189052 chr15:85197271 WDR73 0.58 8.47 0.42 8.01e-16 Schizophrenia; CRC cis rs1062746 0.520 rs17698303 chr16:87329543 C/G cg02258303 chr16:87377426 FBXO31 -0.51 -7.32 -0.37 1.9e-12 Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 2 peripheral neuropathy); CRC cis rs7213347 0.780 rs9892016 chr17:2146422 A/G cg15816464 chr17:2026533 SMG6 0.37 6.38 0.33 6.08e-10 Total body bone mineral density; CRC trans rs11039798 0.841 rs11500573 chr11:48713900 T/G cg03929089 chr4:120376271 NA 0.63 6.06 0.32 3.73e-9 Axial length; CRC cis rs1799949 1.000 rs2037075 chr17:41305826 G/T cg23758822 chr17:41437982 NA 0.79 13.3 0.59 1.32e-32 Menopause (age at onset); CRC cis rs2380220 0.606 rs9488080 chr6:96006973 A/G cg07718321 chr6:96025334 MANEA 0.43 5.67 0.3 3.18e-8 Behavioural disinhibition (generation interaction); CRC cis rs10504229 1.000 rs75037501 chr8:58170136 T/G cg02290350 chr8:58132656 NA -0.42 -5.96 -0.31 6.62e-9 Developmental language disorder (linguistic errors); CRC cis rs4713118 0.513 rs149941 chr6:28001033 T/C cg03623178 chr6:28175578 NA 0.78 11.64 0.54 1.87e-26 Parkinson's disease; CRC cis rs7945705 0.967 rs34842234 chr11:8891894 G/A cg00186954 chr11:8933980 ST5;C11orf17 0.46 7.23 0.37 3.49e-12 Hemoglobin concentration; CRC cis rs4954585 0.683 rs4452212 chr2:137015991 G/A cg05194412 chr2:137003533 NA 0.44 6.82 0.35 4.38e-11 Colorectal cancer; CRC cis rs1506636 1.000 rs2215554 chr7:123347063 A/C cg03229431 chr7:123269106 ASB15 -0.71 -11.93 -0.55 1.6e-27 Plateletcrit;Platelet count; CRC cis rs1348850 0.632 rs13008857 chr2:178514468 G/A cg02961200 chr2:178257176 LOC100130691;AGPS 0.64 9.04 0.45 1.39e-17 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs1707322 0.721 rs10789471 chr1:46215619 G/A cg03146154 chr1:46216737 IPP 0.68 9.85 0.48 3.13e-20 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs3008870 0.701 rs2815367 chr1:67500762 G/A cg08660285 chr1:67390436 MIER1;WDR78 0.55 7.65 0.39 2.28e-13 Lymphocyte percentage of white cells; CRC cis rs7617773 0.780 rs11714944 chr3:48366971 C/A cg11946769 chr3:48343235 NME6 0.72 9.58 0.47 2.48e-19 Coronary artery disease; CRC cis rs4268898 0.932 rs7577964 chr2:24598279 A/G cg06627628 chr2:24431161 ITSN2 0.46 6.91 0.36 2.5e-11 Asthma; CRC cis rs17152411 1.000 rs17152377 chr10:126592852 T/G cg07906193 chr10:126599966 NA 0.58 6.48 0.34 3.33e-10 Height; CRC cis rs11190604 1.000 rs1800662 chr10:102289078 C/A cg07080220 chr10:102295463 HIF1AN 0.47 5.65 0.3 3.39e-8 Palmitoleic acid (16:1n-7) levels; CRC cis rs4731207 0.541 rs6960027 chr7:124543011 G/T cg23710748 chr7:124431027 NA -0.37 -5.98 -0.31 5.75e-9 Cutaneous malignant melanoma; CRC cis rs10504229 0.545 rs56394419 chr8:58128982 T/C cg02290350 chr8:58132656 NA -0.58 -8.16 -0.41 7.29e-15 Developmental language disorder (linguistic errors); CRC cis rs1862618 0.853 rs9283717 chr5:56078659 G/A cg12311346 chr5:56204834 C5orf35 -0.8 -10.22 -0.49 1.85e-21 Initial pursuit acceleration; CRC cis rs1862618 0.802 rs832560 chr5:56124423 T/A cg22800045 chr5:56110881 MAP3K1 0.53 5.94 0.31 7.35e-9 Initial pursuit acceleration; CRC cis rs897984 0.806 rs8052245 chr16:30916430 C/G cg00531865 chr16:30841666 NA 0.48 6.81 0.35 4.58e-11 Dementia with Lewy bodies; CRC cis rs6141769 0.542 rs4425162 chr20:31312916 A/G cg13636640 chr20:31349939 DNMT3B -0.38 -5.6 -0.3 4.44e-8 Subjective well-being; CRC cis rs4731207 0.698 rs10263573 chr7:124469267 A/T cg23710748 chr7:124431027 NA 0.38 6.08 0.32 3.42e-9 Cutaneous malignant melanoma; CRC cis rs7487075 1.000 rs7301001 chr12:46830841 T/C cg22049899 chr12:47219821 SLC38A4 0.31 6.09 0.32 3.12e-9 Itch intensity from mosquito bite; CRC cis rs972578 0.765 rs7286299 chr22:43392856 C/T cg01576275 chr22:43409880 NA -0.38 -5.84 -0.31 1.25e-8 Mean platelet volume; CRC cis rs1707322 0.686 rs2991979 chr1:46055858 A/G cg06784218 chr1:46089804 CCDC17 -0.65 -11.81 -0.55 4.33e-27 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs12824058 0.767 rs4759654 chr12:130815559 A/G cg26677194 chr12:130822605 PIWIL1 0.45 7.29 0.37 2.29e-12 Menopause (age at onset); CRC cis rs7666738 0.830 rs3852122 chr4:98697400 T/C cg05340658 chr4:99064831 C4orf37 0.55 8.16 0.41 6.96e-15 Colonoscopy-negative controls vs population controls; CRC cis rs7618915 0.547 rs10865973 chr3:52718154 A/T cg08222913 chr3:52553049 STAB1 -0.34 -6.12 -0.32 2.7e-9 Bipolar disorder; CRC cis rs9534288 0.700 rs57192057 chr13:46592327 C/G cg15192986 chr13:46630673 CPB2 -0.67 -9.82 -0.48 3.96e-20 Blood protein levels; CRC trans rs2303319 0.504 rs12470590 chr2:162493102 A/G cg01191114 chr3:48936118 SLC25A20 -0.69 -6.0 -0.31 5.27e-9 Cognitive function; CRC cis rs12681288 0.862 rs7814231 chr8:1021103 A/G cg08648136 chr8:956695 NA 0.32 6.26 0.33 1.19e-9 Schizophrenia; CRC cis rs9660992 0.710 rs1172111 chr1:205232980 C/T cg21643547 chr1:205240462 TMCC2 -0.44 -7.2 -0.37 4.13e-12 Mean corpuscular volume;Mean platelet volume; CRC cis rs6089584 0.528 rs4925335 chr20:60627034 G/A cg23262073 chr20:60523788 NA -0.42 -6.63 -0.34 1.38e-10 Body mass index; CRC cis rs6121246 0.580 rs6121016 chr20:30245239 C/T cg13852791 chr20:30311386 BCL2L1 0.67 10.5 0.5 1.99e-22 Mean corpuscular hemoglobin; CRC cis rs4713118 0.868 rs7756968 chr6:27734954 C/G cg12273811 chr6:28175739 NA 0.51 5.66 0.3 3.27e-8 Parkinson's disease; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg03462115 chr16:29801729 KIF22 -0.45 -6.5 -0.34 2.98e-10 Myopia (pathological); CRC cis rs909002 0.800 rs11589306 chr1:32082822 C/G cg13919466 chr1:32135498 COL16A1 -0.3 -5.73 -0.3 2.27e-8 Intelligence (multi-trait analysis); CRC cis rs1499614 0.803 rs1922723 chr7:66175063 C/T cg18252515 chr7:66147081 NA -1.24 -14.6 -0.63 1.48e-37 Gout; CRC cis rs9913156 0.793 rs55682338 chr17:4582183 G/A cg00122941 chr17:4613640 ARRB2 0.63 7.57 0.39 3.83e-13 Lymphocyte counts; CRC cis rs977987 0.751 rs56004344 chr16:75474189 T/C cg03315344 chr16:75512273 CHST6 0.55 9.45 0.46 6.4e-19 Dupuytren's disease; CRC trans rs6129564 0.731 rs6016332 chr20:38988846 A/T cg12409982 chr3:137489312 NA -0.44 -5.97 -0.31 6e-9 Cranial base width; CRC cis rs9611565 0.765 rs132915 chr22:41805782 T/C cg03806693 chr22:41940476 POLR3H 0.99 12.4 0.56 2.99e-29 Vitiligo; CRC cis rs4819052 1.000 rs733739 chr21:46666210 A/G cg11663144 chr21:46675770 NA -0.8 -11.67 -0.54 1.47e-26 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs17688076 0.511 rs2418738 chr16:68122604 G/C cg08314208 chr16:67682810 RLTPR -0.49 -5.87 -0.31 1.06e-8 C-reactive protein levels or HDL-cholesterol levels (pleiotropy); CRC cis rs7107174 0.892 rs3018313 chr11:77989644 C/T cg02023728 chr11:77925099 USP35 0.48 6.99 0.36 1.49e-11 Testicular germ cell tumor; CRC cis rs1552244 1.000 rs76041173 chr3:10078695 G/T cg16606324 chr3:10149918 C3orf24 0.73 9.74 0.47 7.36e-20 Alzheimer's disease; CRC cis rs870825 0.860 rs72703519 chr4:185602707 G/A cg04058563 chr4:185651563 MLF1IP 0.56 5.87 0.31 1.04e-8 Blood protein levels; CRC cis rs10256972 0.577 rs4999286 chr7:1199506 C/G cg03188948 chr7:1209495 NA 0.57 8.48 0.42 7.82e-16 Longevity;Endometriosis; CRC cis rs7870657 0.535 rs7019370 chr9:71743826 A/G cg14326805 chr9:71737756 TJP2 0.31 6.44 0.33 4.31e-10 Seasonality; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg01546243 chr14:61748019 TMEM30B 0.43 6.03 0.32 4.52e-9 Thyroid stimulating hormone; CRC cis rs4332037 0.851 rs10268609 chr7:1962163 A/C cg21155852 chr7:2048760 MAD1L1 -0.43 -6.01 -0.31 4.92e-9 Bipolar disorder; CRC cis rs9467711 0.591 rs13206501 chr6:26110148 T/C cg08501292 chr6:25962987 TRIM38 0.6 6.03 0.32 4.4e-9 Autism spectrum disorder or schizophrenia; CRC cis rs9486719 0.857 rs9285393 chr6:97020917 C/A cg18709589 chr6:96969512 KIAA0776 -0.51 -6.4 -0.33 5.46e-10 Migraine;Coronary artery disease; CRC cis rs743757 0.878 rs1467914 chr3:50523668 A/G cg09545109 chr3:50388910 TUSC4;CYB561D2 0.45 6.2 0.32 1.66e-9 Diastolic blood pressure; CRC cis rs4332037 0.539 rs11762636 chr7:2061111 C/A cg23378565 chr7:2036160 MAD1L1 -0.43 -6.09 -0.32 3.14e-9 Bipolar disorder; CRC cis rs4713118 0.513 rs149951 chr6:28033087 T/C cg15845792 chr6:28175446 NA 0.78 11.57 0.54 3.33e-26 Parkinson's disease; CRC cis rs2032447 0.670 rs198850 chr6:26104670 A/C cg18357526 chr6:26021779 HIST1H4A -0.68 -10.18 -0.49 2.43e-21 Intelligence (multi-trait analysis); CRC cis rs3823572 0.542 rs28529474 chr7:133634908 C/T cg03336402 chr7:133662267 EXOC4 0.67 10.32 0.49 8.37e-22 Intelligence (multi-trait analysis); CRC cis rs2842992 0.915 rs2758335 chr6:160111011 G/A cg19482086 chr6:160211437 TCP1;MRPL18 0.69 8.6 0.43 3.33e-16 Age-related macular degeneration (geographic atrophy); CRC cis rs7772486 0.754 rs702306 chr6:145991029 T/C cg05347473 chr6:146136440 FBXO30 -0.41 -6.13 -0.32 2.53e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs6938 0.662 rs12487 chr15:75136694 A/G cg17294928 chr15:75287854 SCAMP5 0.53 8.08 0.41 1.24e-14 Breast cancer; CRC cis rs597539 0.690 rs647661 chr11:68625875 T/C cg06112835 chr11:68658793 MRPL21 0.46 7.41 0.38 1.07e-12 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg14317554 chr3:184870948 C3orf70 0.35 6.24 0.33 1.38e-9 Liver disease severity in Alagille syndrome; CRC cis rs311392 0.525 rs311391 chr8:55103542 T/G cg06042504 chr8:55087323 NA -0.36 -5.76 -0.3 1.95e-8 Pelvic organ prolapse (moderate/severe); CRC cis rs4481887 0.927 rs4916121 chr1:248432003 C/T cg00666640 chr1:248458726 OR2T12 0.58 10.26 0.49 1.31e-21 Common traits (Other); CRC cis rs6662572 0.686 rs59091734 chr1:46285809 A/G cg08644498 chr1:46502608 NA 0.44 6.92 0.36 2.37e-11 Blood protein levels; CRC cis rs7951870 0.645 rs2070852 chr11:46744925 C/G cg19486271 chr11:47235900 DDB2 -0.46 -7.26 -0.37 2.86e-12 Schizophrenia; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg25789511 chr20:60757919 GTPBP5 0.38 6.1 0.32 2.94e-9 Liver disease severity in Alagille syndrome; CRC trans rs2727020 0.615 rs10128582 chr11:49447424 C/T cg11707556 chr5:10655725 ANKRD33B -0.37 -7.05 -0.36 1.05e-11 Coronary artery disease; CRC cis rs7781266 0.790 rs11772553 chr7:133123204 G/A cg03336402 chr7:133662267 EXOC4 0.49 5.81 0.31 1.47e-8 Educational attainment (college completion); CRC cis rs7107174 1.000 rs4945274 chr11:78109260 G/A cg02023728 chr11:77925099 USP35 0.42 7.18 0.37 4.56e-12 Testicular germ cell tumor; CRC cis rs8031584 0.918 rs34095794 chr15:31269691 C/T cg08109568 chr15:31115862 NA -0.52 -8.8 -0.44 7.82e-17 Huntington's disease progression; CRC cis rs10504229 0.906 rs111838497 chr8:58185620 A/C cg01721255 chr8:58191610 C8orf71 0.49 6.17 0.32 2e-9 Developmental language disorder (linguistic errors); CRC cis rs1055129 0.560 rs2608880 chr17:73938957 C/T cg14829360 chr17:73884958 NA -0.34 -5.83 -0.31 1.31e-8 White matter hyperintensity burden; CRC cis rs1728785 1.000 rs1170442 chr16:68574064 G/T cg02972257 chr16:68554789 NA -0.58 -7.23 -0.37 3.43e-12 Ulcerative colitis; CRC cis rs10504229 0.728 rs17804720 chr8:58154565 T/C cg02290350 chr8:58132656 NA -0.51 -6.57 -0.34 1.98e-10 Developmental language disorder (linguistic errors); CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg27620946 chr8:42011116 AP3M2 -0.54 -6.74 -0.35 6.97e-11 Diisocyanate-induced asthma; CRC cis rs6951245 0.872 rs112309216 chr7:1100296 A/T cg24642844 chr7:1081250 C7orf50 -0.76 -9.16 -0.45 5.78e-18 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs6429082 1.000 rs2055127 chr1:235598973 C/T cg26050004 chr1:235667680 B3GALNT2 -0.44 -6.3 -0.33 9.35e-10 Adiposity; CRC cis rs6445967 1.000 rs13082844 chr3:58318261 G/A cg23715586 chr3:58305044 RPP14 0.36 5.96 0.31 6.64e-9 Platelet count; CRC trans rs2710642 0.962 rs1828398 chr2:63034870 A/G cg05376469 chr2:102649931 NA 0.37 6.1 0.32 2.94e-9 LDL cholesterol levels;LDL cholesterol; CRC trans rs7830939 1.000 rs7830939 chr8:9380132 A/G cg06636001 chr8:8085503 FLJ10661 -0.48 -6.76 -0.35 6.38e-11 Neuroticism; CRC cis rs4660306 0.677 rs781059 chr1:45934562 A/G cg03123370 chr1:45965343 CCDC163P;MMACHC -0.48 -6.42 -0.33 4.68e-10 Homocysteine levels; CRC trans rs116095464 0.681 rs10060016 chr5:241100 T/C cg00938859 chr5:1591904 SDHAP3 0.73 7.81 0.4 7.59e-14 Breast cancer; CRC cis rs6952808 0.595 rs3778983 chr7:2166319 T/G cg04267008 chr7:1944627 MAD1L1 -0.65 -9.02 -0.45 1.57e-17 Bipolar disorder and schizophrenia; CRC cis rs2412459 1.000 rs8023482 chr15:40307095 A/C cg20255370 chr15:40268687 EIF2AK4 -0.78 -7.12 -0.37 6.86e-12 Response to haloperidol in psychosis; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg19978540 chr12:3409405 NA 0.46 6.65 0.34 1.23e-10 Response to antipsychotic treatment; CRC cis rs4862750 0.832 rs6836426 chr4:187897837 T/G cg03647317 chr4:187891568 NA -0.55 -10.47 -0.5 2.47e-22 Lobe attachment (rater-scored or self-reported); CRC cis rs12142240 0.738 rs41293277 chr1:46806550 C/T cg00530320 chr1:46809349 NSUN4 0.58 7.84 0.4 6.26e-14 Menopause (age at onset); CRC cis rs8072100 0.805 rs67919208 chr17:45771873 T/C cg19784903 chr17:45786737 TBKBP1 -0.36 -5.89 -0.31 9.61e-9 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs873946 0.504 rs12775990 chr10:134575836 C/T cg26818010 chr10:134567672 INPP5A -0.64 -8.55 -0.43 4.64e-16 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CRC cis rs28386778 0.901 rs2665855 chr17:61965143 A/G cg22520471 chr17:61851767 DDX42;CCDC47 0.74 10.95 0.52 5.42e-24 Prudent dietary pattern; CRC cis rs9487051 0.676 rs9372208 chr6:109596168 A/G cg21918786 chr6:109611834 NA -0.41 -7.17 -0.37 4.84e-12 Reticulocyte fraction of red cells; CRC cis rs950776 0.518 rs12902493 chr15:78819275 C/G cg06917634 chr15:78832804 PSMA4 0.66 10.64 0.51 6.47e-23 Sudden cardiac arrest; CRC cis rs13191362 0.938 rs35760705 chr6:163020637 G/A cg21926612 chr6:163149169 PACRG;PARK2 0.75 10.84 0.51 1.3e-23 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs7605827 0.930 rs4668898 chr2:15511502 T/C cg19274914 chr2:15703543 NA 0.39 6.01 0.31 4.81e-9 Educational attainment (years of education); CRC cis rs4665809 1.000 rs7588802 chr2:26277789 A/G cg04944784 chr2:26401820 FAM59B -0.66 -8.59 -0.43 3.56e-16 Gut microbiome composition (summer); CRC cis rs4481887 1.000 rs7517319 chr1:248466408 C/A cg00666640 chr1:248458726 OR2T12 0.52 9.22 0.45 3.57e-18 Common traits (Other); CRC cis rs1552244 0.935 rs6805869 chr3:10119917 T/C cg00166722 chr3:10149974 C3orf24 0.67 9.26 0.45 2.71e-18 Alzheimer's disease; CRC cis rs7615952 0.576 rs4646748 chr3:125826329 G/A cg04553112 chr3:125709451 NA -0.52 -6.02 -0.32 4.56e-9 Blood pressure (smoking interaction); CRC cis rs61008539 0.893 rs4719460 chr7:859610 C/T cg07138768 chr7:917805 C7orf20 -0.3 -5.83 -0.31 1.33e-8 Perceived unattractiveness to mosquitoes; CRC cis rs9891119 0.965 rs17886724 chr17:40496163 A/G cg06270615 chr17:40516068 STAT3 -0.27 -5.97 -0.31 6.21e-9 Multiple sclerosis;Crohn's disease; CRC cis rs12325245 0.536 rs8058781 chr16:58653838 G/A cg19824325 chr16:58548873 SETD6 1.0 6.84 0.35 3.87e-11 Schizophrenia; CRC cis rs12946454 0.696 rs4792819 chr17:43247957 A/C cg10701640 chr17:43249399 NA 0.49 11.88 0.55 2.41e-27 Systolic blood pressure; CRC cis rs909674 0.818 rs7364148 chr22:39842165 T/C cg11247378 chr22:39784982 NA -0.37 -6.72 -0.35 7.79e-11 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; CRC cis rs9902453 0.808 rs62068617 chr17:28144728 A/G cg26525008 chr17:28256777 EFCAB5;SSH2 0.59 8.86 0.44 4.96e-17 Coffee consumption (cups per day); CRC cis rs62432291 0.681 rs385438 chr6:159656213 A/G cg14500486 chr6:159655392 FNDC1 -0.69 -9.66 -0.47 1.33e-19 Joint mobility (Beighton score); CRC cis rs9467711 0.606 rs34781270 chr6:26593037 A/G cg08501292 chr6:25962987 TRIM38 0.88 6.11 0.32 2.84e-9 Autism spectrum disorder or schizophrenia; CRC cis rs40363 0.645 rs250631 chr16:3523215 G/C cg05754148 chr16:3507555 NAT15 0.54 7.42 0.38 9.98e-13 Tuberculosis; CRC cis rs7727544 0.735 rs4705933 chr5:131678412 G/A cg11843238 chr5:131593191 PDLIM4 0.31 5.7 0.3 2.73e-8 Blood metabolite levels; CRC cis rs2404602 0.583 rs12913096 chr15:76551852 C/T cg23625390 chr15:77176239 SCAPER 0.41 5.95 0.31 6.81e-9 Blood metabolite levels; CRC cis rs931127 0.719 rs7949980 chr11:65445950 T/C cg27068330 chr11:65405492 SIPA1 -0.44 -6.06 -0.32 3.8e-9 Systemic lupus erythematosus; CRC cis rs1707322 0.686 rs2230659 chr1:46078884 C/T cg06784218 chr1:46089804 CCDC17 -0.66 -12.18 -0.56 1.94e-28 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs7727544 0.571 rs12521097 chr5:131575338 G/A cg09877947 chr5:131593287 PDLIM4 0.33 6.13 0.32 2.55e-9 Blood metabolite levels; CRC cis rs1800469 1.000 rs2241714 chr19:41869392 C/T cg09537434 chr19:41945824 ATP5SL 0.54 6.75 0.35 6.65e-11 Colorectal cancer; CRC cis rs875971 0.862 rs11765791 chr7:65936574 A/G cg18876405 chr7:65276391 NA 0.52 8.24 0.41 4.2e-15 Aortic root size; CRC cis rs6662572 0.737 rs72690901 chr1:46378028 C/T cg08644498 chr1:46502608 NA 0.43 6.77 0.35 6.1e-11 Blood protein levels; CRC cis rs3806843 0.900 rs2563279 chr5:140131535 G/A cg16607685 chr5:140181889 PCDHA2;PCDHA1;PCDHA3 0.27 6.11 0.32 2.75e-9 Depressive symptoms (multi-trait analysis); CRC cis rs6499255 0.904 rs74029403 chr16:69710472 A/C cg15192750 chr16:69999425 NA 0.64 8.28 0.42 3.19e-15 IgE levels; CRC cis rs1499614 0.901 rs3936 chr7:66126489 C/T cg12463550 chr7:65579703 CRCP 0.64 5.86 0.31 1.12e-8 Gout; CRC cis rs34779708 0.966 rs1148245 chr10:35511894 C/T cg03585969 chr10:35415529 CREM 0.53 7.26 0.37 2.77e-12 Inflammatory bowel disease;Crohn's disease; CRC cis rs71007656 1 rs71007656 chr10:37970845 CGGCTG/C cg25427524 chr10:38739819 LOC399744 -0.72 -11.96 -0.55 1.31e-27 Extrinsic epigenetic age acceleration; CRC cis rs9916302 0.706 rs8069074 chr17:37685401 C/T cg07936489 chr17:37558343 FBXL20 0.94 12.19 0.56 1.79e-28 Glomerular filtration rate (creatinine); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg19850565 chr19:35168394 ZNF302 0.42 6.13 0.32 2.5e-9 Response to antipsychotic treatment; CRC cis rs17155006 0.783 rs410286 chr7:107749257 A/T cg05962710 chr7:107745446 LAMB4 -0.41 -7.36 -0.38 1.46e-12 Pneumococcal bacteremia; CRC cis rs9611565 0.729 rs202654 chr22:41841034 G/A cg03806693 chr22:41940476 POLR3H 0.76 10.2 0.49 2.06e-21 Vitiligo; CRC cis rs2019137 0.539 rs4849177 chr2:113982584 T/C cg21610815 chr2:113994035 PAX8;LOC654433;LOC440839 0.57 8.62 0.43 2.88e-16 Lymphocyte counts; CRC cis rs6502050 0.835 rs8073351 chr17:80127625 A/G cg25804541 chr17:80189381 SLC16A3 -0.3 -5.84 -0.31 1.23e-8 Life satisfaction; CRC cis rs10089 1.000 rs4836360 chr5:127458161 T/C cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.77 10.84 0.51 1.29e-23 Ileal carcinoids; CRC cis rs7224685 0.501 rs812996 chr17:3965674 T/C cg05562828 chr17:3906858 NA 0.67 12.55 0.57 8.33e-30 Type 2 diabetes; CRC cis rs7605827 0.836 rs9287662 chr2:15595994 A/G cg19274914 chr2:15703543 NA 0.39 5.9 0.31 9.14e-9 Educational attainment (years of education); CRC cis rs17376456 0.825 rs28705226 chr5:93233135 T/C cg09848695 chr5:92956644 FAM172A;MIR2277 0.66 6.21 0.32 1.56e-9 Diabetic retinopathy; CRC cis rs1198872 0.526 rs57282335 chr2:10928207 G/A cg15705551 chr2:10952987 PDIA6 0.46 6.34 0.33 7.68e-10 Cardiac Troponin-T levels; CRC trans rs6561151 0.681 rs10507521 chr13:44441834 C/G cg17145862 chr1:211918768 LPGAT1 -0.47 -6.38 -0.33 5.86e-10 Crohn's disease; CRC cis rs76993477 0.666 rs77749308 chr1:169713467 A/G cg03211132 chr1:169703751 SELE 0.58 5.7 0.3 2.72e-8 Tonsillectomy; CRC cis rs1707322 0.721 rs10890336 chr1:46111056 C/T cg03146154 chr1:46216737 IPP 0.68 9.97 0.48 1.2e-20 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs6088580 0.634 rs6059890 chr20:33101653 G/C cg24642439 chr20:33292090 TP53INP2 0.4 6.71 0.35 8.7e-11 Glomerular filtration rate (creatinine); CRC cis rs1552244 0.810 rs6809572 chr3:10100145 G/A cg08888203 chr3:10149979 C3orf24 0.73 10.16 0.49 2.86e-21 Alzheimer's disease; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg10779981 chr1:207925104 CD46 0.43 5.98 0.31 5.67e-9 Response to antipsychotic treatment; CRC cis rs600806 0.751 rs7551176 chr1:109961965 C/T cg23032129 chr1:109941072 SORT1 -0.28 -5.81 -0.31 1.47e-8 Intelligence (multi-trait analysis); CRC cis rs2204008 0.687 rs11181339 chr12:38322271 G/T cg26384229 chr12:38710491 ALG10B 0.65 9.73 0.47 8.1e-20 Bladder cancer; CRC cis rs875971 0.862 rs4368860 chr7:65608482 C/G cg18876405 chr7:65276391 NA -0.51 -8.34 -0.42 2e-15 Aortic root size; CRC cis rs950169 1.000 rs35658069 chr15:84780146 C/T cg03959625 chr15:84868606 LOC388152 0.42 6.36 0.33 6.88e-10 Schizophrenia; CRC cis rs76878669 0.561 rs56321771 chr11:66161072 C/T cg24851651 chr11:66362959 CCS -0.39 -6.86 -0.35 3.45e-11 Educational attainment (years of education); CRC cis rs755249 0.532 rs61779278 chr1:39834617 A/G cg18385671 chr1:39797026 MACF1 -0.4 -5.78 -0.3 1.74e-8 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs2380220 0.510 rs9387562 chr6:96057006 G/T cg07718321 chr6:96025334 MANEA 0.58 7.27 0.37 2.68e-12 Behavioural disinhibition (generation interaction); CRC cis rs7998202 0.667 rs282584 chr13:113349819 C/T cg02820901 chr13:113351484 ATP11A -0.55 -6.38 -0.33 6e-10 Glycated hemoglobin levels; CRC trans rs2303319 0.504 rs62187609 chr2:162431500 C/T cg03757145 chr4:76555832 CDKL2 -0.68 -6.04 -0.32 4.06e-9 Cognitive function; CRC cis rs12701220 0.655 rs6463317 chr7:1159243 G/A cg00990874 chr7:1149470 C7orf50 -0.52 -6.9 -0.36 2.72e-11 Bronchopulmonary dysplasia; CRC cis rs55823223 0.564 rs936396 chr17:73846829 C/G cg14829360 chr17:73884958 NA -0.46 -7.27 -0.37 2.64e-12 Psoriasis; CRC cis rs1030877 0.960 rs3792047 chr2:105901553 A/G cg02079111 chr2:105885981 TGFBRAP1 -0.59 -10.07 -0.49 5.95e-21 Obesity-related traits; CRC cis rs897984 0.609 rs732173 chr16:31050023 C/A cg00531865 chr16:30841666 NA -0.42 -5.95 -0.31 6.87e-9 Dementia with Lewy bodies; CRC cis rs1799949 0.965 rs8176193 chr17:41231516 C/T cg01879757 chr17:41196368 BRCA1 -0.41 -6.07 -0.32 3.56e-9 Menopause (age at onset); CRC cis rs526821 0.595 rs629948 chr11:55356448 G/A cg04317927 chr11:55418816 OR4S2 0.4 6.85 0.35 3.57e-11 Pediatric bone mineral density (spine); CRC cis rs1448094 0.534 rs974818 chr12:86144307 T/C cg02569458 chr12:86230093 RASSF9 -0.48 -8.09 -0.41 1.13e-14 Major depressive disorder; CRC cis rs17253792 0.822 rs78922774 chr14:56115302 T/A cg01858014 chr14:56050164 KTN1 -0.87 -7.23 -0.37 3.31e-12 Putamen volume; CRC cis rs6502050 0.761 rs9908277 chr17:80060829 T/C cg19223190 chr17:80058835 NA -0.45 -7.16 -0.37 5.41e-12 Life satisfaction; CRC cis rs9303280 0.806 rs9909593 chr17:37970149 C/T cg17344932 chr17:38183730 MED24;SNORD124 -0.35 -5.66 -0.3 3.23e-8 Self-reported allergy; CRC cis rs4805272 0.539 rs11883172 chr19:29318536 C/T cg12667521 chr19:29218732 NA 0.46 6.48 0.34 3.42e-10 Plasma omega-3 polyunsaturated fatty acid levels (docosahexaenoic acid); CRC cis rs10242455 0.702 rs112475236 chr7:99044679 A/G cg18809830 chr7:99032528 PTCD1 -0.94 -7.34 -0.38 1.69e-12 Blood metabolite levels; CRC cis rs2070677 0.866 rs2492664 chr10:135387240 G/T cg16964102 chr10:135390573 NA 0.53 7.42 0.38 1.01e-12 Gout; CRC cis rs78456975 1.000 rs6720874 chr2:1580504 A/G cg26248373 chr2:1572462 NA -0.67 -8.15 -0.41 7.53e-15 Placebo response in major depressive disorder (% change in symptom score); CRC cis rs3741404 0.620 rs12787945 chr11:63977546 G/A cg18225595 chr11:63971243 STIP1 0.53 8.52 0.43 5.74e-16 Platelet count; CRC cis rs7932354 0.528 rs11039074 chr11:47081732 C/T cg19486271 chr11:47235900 DDB2 -0.45 -6.46 -0.34 3.8e-10 Bone mineral density (hip);Bone mineral density; CRC cis rs11785400 0.793 rs4336593 chr8:143739647 A/C cg24634471 chr8:143751801 JRK -0.46 -6.3 -0.33 9.34e-10 Schizophrenia; CRC cis rs274567 0.501 rs581968 chr5:131710202 G/A cg12564285 chr5:131593104 PDLIM4 -0.45 -7.51 -0.38 5.66e-13 Blood metabolite levels; CRC cis rs4604732 0.631 rs11490201 chr1:247626262 A/G cg02104434 chr1:247694406 LOC148824;OR2C3 0.6 8.85 0.44 5.65e-17 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CRC cis rs9487051 0.872 rs9386791 chr6:109608497 C/T cg12927641 chr6:109611667 NA -0.37 -6.75 -0.35 6.53e-11 Reticulocyte fraction of red cells; CRC cis rs7539542 0.556 rs3820152 chr1:202878492 A/T cg19681188 chr1:202830198 LOC148709 -0.41 -6.01 -0.31 5.01e-9 Mean platelet volume; CRC cis rs3733346 0.520 rs62297086 chr4:909040 G/A cg20814179 chr4:940893 TMEM175 0.57 10.55 0.5 1.31e-22 Sjögren's syndrome; CRC cis rs7605827 0.897 rs1996518 chr2:15517419 A/G cg19274914 chr2:15703543 NA 0.39 5.93 0.31 7.51e-9 Educational attainment (years of education); CRC cis rs6504622 0.720 rs4968304 chr17:45140601 A/C cg16759221 chr17:45003025 GOSR2 0.44 6.8 0.35 5.08e-11 Orofacial clefts; CRC cis rs902774 0.818 rs55958994 chr12:53301019 C/T cg14581129 chr12:53358946 NA -0.54 -6.16 -0.32 2.14e-9 Prostate cancer; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg01111397 chr2:172967676 DLX2 0.46 6.26 0.33 1.21e-9 Anxiety disorder; CRC cis rs6988985 0.589 rs6471580 chr8:143986701 A/G cg10324643 chr8:143916377 GML 0.37 6.38 0.33 6.06e-10 Plasma androstenedione levels in resected early stage-receptor positive breast cancer; CRC cis rs12681288 0.862 rs7814070 chr8:1020991 A/G cg04851639 chr8:1020857 NA -0.36 -7.58 -0.39 3.6e-13 Schizophrenia; CRC cis rs6089584 0.566 rs6061972 chr20:60610245 C/T cg23262073 chr20:60523788 NA -0.42 -6.73 -0.35 7.35e-11 Body mass index; CRC cis rs2857891 1.000 rs2595500 chr11:6963165 C/T cg12728517 chr11:6947552 ZNF215 -0.56 -6.41 -0.33 4.95e-10 Response to cytadine analogues (cytosine arabinoside); CRC cis rs6502050 0.835 rs12945993 chr17:80129485 T/C cg22110888 chr17:80059540 CCDC57 0.4 6.42 0.33 4.76e-10 Life satisfaction; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg19199531 chr22:20104664 TRMT2A;RANBP1 0.47 6.69 0.35 9.75e-11 Anxiety disorder; CRC cis rs9911578 0.934 rs58092632 chr17:57111101 T/C cg05425664 chr17:57184151 TRIM37 0.52 8.22 0.41 4.86e-15 Intelligence (multi-trait analysis); CRC cis rs2994684 0.736 rs11008385 chr10:31453788 A/C cg06335251 chr10:31320888 ZNF438 0.43 6.39 0.33 5.62e-10 Response to antipsychotic treatment; CRC cis rs9976767 0.637 rs9325635 chr21:43823289 G/A cg23042151 chr21:43824109 UBASH3A -0.41 -7.02 -0.36 1.31e-11 Type 1 diabetes; CRC trans rs1814175 0.645 rs7395438 chr11:49877379 G/T cg11707556 chr5:10655725 ANKRD33B -0.51 -9.67 -0.47 1.25e-19 Height; CRC cis rs56114371 0.530 rs9357045 chr6:27688927 G/A cg06470822 chr6:28175283 NA 0.54 6.23 0.32 1.45e-9 Breast cancer; CRC cis rs17270561 0.609 rs9358878 chr6:25740273 C/T cg16482183 chr6:26056742 HIST1H1C 0.83 10.65 0.51 5.97e-23 Iron status biomarkers; CRC cis rs9926296 0.581 rs2108838 chr16:89904426 A/G cg27121462 chr16:89883253 FANCA 0.44 6.54 0.34 2.41e-10 Vitiligo; CRC cis rs3823572 0.542 rs2953634 chr7:133640386 C/T cg03336402 chr7:133662267 EXOC4 0.66 10.01 0.48 9.19e-21 Intelligence (multi-trait analysis); CRC cis rs780096 0.546 rs715325 chr2:27725572 C/A cg12648201 chr2:27665141 KRTCAP3 -0.3 -6.02 -0.32 4.58e-9 Total body bone mineral density; CRC cis rs16859517 0.546 rs56772456 chr2:220190457 G/C cg00436969 chr2:220197716 RESP18 -0.46 -7.0 -0.36 1.46e-11 Height; CRC trans rs11039798 0.502 rs961863 chr11:48417021 T/C cg03929089 chr4:120376271 NA -0.63 -6.58 -0.34 1.86e-10 Axial length; CRC cis rs9463078 0.774 rs10948222 chr6:45244415 T/C cg25276700 chr6:44698697 NA -0.27 -6.49 -0.34 3.14e-10 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; CRC cis rs6964587 0.934 rs6973792 chr7:91749798 C/A cg17063962 chr7:91808500 NA 0.8 12.98 0.58 2.25e-31 Breast cancer; CRC cis rs2535633 0.631 rs2710314 chr3:52969128 T/C cg11645453 chr3:52864694 ITIH4 -0.43 -8.39 -0.42 1.42e-15 Body mass index; CRC cis rs13064411 0.696 rs6808394 chr3:113122524 T/G cg10517650 chr3:113235015 CCDC52 -0.38 -6.09 -0.32 3.13e-9 Response to simvastatin treatment (PCSK9 protein level change); CRC cis rs3796352 0.892 rs58515094 chr3:52995575 C/T cg27565382 chr3:53032988 SFMBT1 0.7 6.19 0.32 1.76e-9 Immune reponse to smallpox (secreted IL-2); CRC cis rs3126085 0.935 rs4845741 chr1:152183474 A/G cg09127314 chr1:152161683 NA 0.52 6.82 0.35 4.45e-11 Atopic dermatitis; CRC cis rs6938 0.618 rs1133323 chr15:75212225 C/T cg05627522 chr15:75251581 NA 0.4 6.02 0.32 4.6e-9 Breast cancer; CRC trans rs9630182 0.561 rs10832036 chr11:13462853 G/T cg13741668 chr9:85679694 NA 0.37 6.02 0.31 4.78e-9 Bone mineral density; CRC cis rs2303745 0.589 rs6512179 chr19:17399105 T/C cg15110403 chr19:17392923 ANKLE1 -0.36 -5.74 -0.3 2.11e-8 Systemic lupus erythematosus; CRC cis rs2073300 0.609 rs6132609 chr20:23400412 A/C cg12062639 chr20:23401060 NAPB 0.84 7.63 0.39 2.54e-13 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs9847710 0.733 rs2581809 chr3:53089683 G/C cg18099408 chr3:52552593 STAB1 0.4 6.03 0.32 4.53e-9 Ulcerative colitis; CRC cis rs4332037 0.664 rs73046334 chr7:1887037 T/C cg21155852 chr7:2048760 MAD1L1 -0.42 -6.05 -0.32 3.95e-9 Bipolar disorder; CRC cis rs853679 0.517 rs4713152 chr6:28137454 G/A cg03623178 chr6:28175578 NA 0.98 12.66 0.57 3.31e-30 Depression; CRC cis rs763014 0.966 rs4247097 chr16:654224 G/A cg04562611 chr16:615315 C16orf11 0.35 5.96 0.31 6.41e-9 Height; CRC cis rs4481887 0.927 rs6689193 chr1:248482900 T/A cg00666640 chr1:248458726 OR2T12 0.49 8.34 0.42 2.08e-15 Common traits (Other); CRC trans rs7395662 0.745 rs10838830 chr11:48233932 A/G cg21153622 chr11:89784906 NA 0.45 6.91 0.36 2.46e-11 HDL cholesterol; CRC cis rs7725052 0.609 rs10213846 chr5:40442869 A/C cg09067459 chr5:40385259 NA 0.4 6.7 0.35 8.85e-11 Pediatric autoimmune diseases; CRC cis rs2404618 0.504 rs2906567 chr8:1494118 C/T cg02903104 chr8:1507517 DLGAP2 0.47 8.24 0.41 4.26e-15 Lung cancer; CRC cis rs10256972 0.552 rs2949192 chr7:1203841 C/T cg16145915 chr7:1198662 ZFAND2A -0.5 -10.53 -0.5 1.49e-22 Longevity;Endometriosis; CRC cis rs28374715 0.662 rs8038983 chr15:41473316 G/A cg18705301 chr15:41695430 NDUFAF1 -0.91 -13.9 -0.61 6.99e-35 Ulcerative colitis; CRC cis rs13064411 0.696 rs9836396 chr3:113184282 T/C cg18753928 chr3:113234510 CCDC52 -0.66 -10.34 -0.5 6.91e-22 Response to simvastatin treatment (PCSK9 protein level change); CRC cis rs881375 0.900 rs1930786 chr9:123691469 C/G cg14255062 chr9:123606675 PSMD5;LOC253039 0.4 5.89 0.31 9.49e-9 Rheumatoid arthritis; CRC cis rs4862750 0.914 rs6553026 chr4:187875648 C/T cg22105103 chr4:187893119 NA 0.63 11.43 0.53 1.09e-25 Lobe attachment (rater-scored or self-reported); CRC cis rs853679 0.517 rs9393893 chr6:28109262 T/C cg15845792 chr6:28175446 NA 1.04 13.89 0.61 7.67e-35 Depression; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg09372928 chr1:6845395 CAMTA1 0.4 6.41 0.33 5.19e-10 Liver disease severity in Alagille syndrome; CRC cis rs1348850 0.914 rs7573763 chr2:178249808 C/T cg02961200 chr2:178257176 LOC100130691;AGPS 0.61 9.09 0.45 9.54e-18 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs2292864 0.764 rs72825627 chr17:45386289 C/G cg18085866 chr17:45331354 ITGB3 -0.58 -5.61 -0.3 4.39e-8 Left atrial antero-posterior diameter; CRC cis rs11711311 0.955 rs67550112 chr3:113401988 C/T cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.5 -6.61 -0.34 1.51e-10 IgG glycosylation; CRC cis rs8078723 0.714 rs3859187 chr17:38150613 C/A cg17467752 chr17:38218738 THRA -0.57 -9.09 -0.45 9.73e-18 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); CRC cis rs9911578 1.000 rs8076121 chr17:57041699 G/A cg05425664 chr17:57184151 TRIM37 -0.5 -7.88 -0.4 4.85e-14 Intelligence (multi-trait analysis); CRC cis rs6840360 0.967 rs6535817 chr4:152641941 G/C cg09659197 chr4:152720779 NA 0.53 11.47 0.53 7.79e-26 Intelligence (multi-trait analysis); CRC cis rs4604732 0.631 rs12091081 chr1:247623064 C/T cg02104434 chr1:247694406 LOC148824;OR2C3 0.64 8.69 0.43 1.75e-16 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CRC cis rs4713118 0.866 rs2179094 chr6:27741825 T/C cg15845792 chr6:28175446 NA 0.68 8.96 0.44 2.46e-17 Parkinson's disease; CRC cis rs1799949 1.000 rs4793212 chr17:41302750 T/C cg19454999 chr17:41278357 BRCA1;NBR2 0.54 8.28 0.42 3.06e-15 Menopause (age at onset); CRC cis rs4713118 0.516 rs4713142 chr6:28106347 T/G cg03623178 chr6:28175578 NA 0.96 12.57 0.57 7.23e-30 Parkinson's disease; CRC cis rs7818382 0.967 rs7812465 chr8:96050557 C/T cg16049864 chr8:95962084 TP53INP1 0.59 10.18 0.49 2.42e-21 Alzheimer's disease (late onset); CRC cis rs4862750 0.832 rs6836076 chr4:187899660 A/C cg03452623 chr4:187889614 NA -0.92 -22.45 -0.78 2.37e-68 Lobe attachment (rater-scored or self-reported); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg00567696 chr6:46097521 ENPP4 0.45 6.64 0.34 1.33e-10 Response to antipsychotic treatment; CRC cis rs17095355 1.000 rs12570820 chr10:111732507 G/A cg00817464 chr10:111662876 XPNPEP1 -0.63 -8.57 -0.43 4.09e-16 Biliary atresia; CRC trans rs800082 0.516 rs9811286 chr3:144230367 T/C cg24215973 chr2:240111563 HDAC4 0.46 6.44 0.33 4.18e-10 Smoking behavior; CRC cis rs9914988 0.943 rs9303621 chr17:27161138 A/G cg07195577 chr17:27052828 TLCD1 0.41 5.95 0.31 6.86e-9 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs10504229 0.861 rs116964504 chr8:58185354 A/C cg22535103 chr8:58192502 C8orf71 -0.82 -12.27 -0.56 9.63e-29 Developmental language disorder (linguistic errors); CRC cis rs9914988 0.667 rs11652544 chr17:27252989 C/T cg16670446 chr17:27188758 MIR451;MIR144 0.48 6.19 0.32 1.8e-9 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs743757 0.878 rs6786523 chr3:50524221 A/G cg09545109 chr3:50388910 TUSC4;CYB561D2 -0.42 -5.76 -0.3 1.9e-8 Diastolic blood pressure; CRC cis rs6901250 0.851 rs339324 chr6:117195024 C/T cg12892004 chr6:117198278 RFX6 -0.44 -6.89 -0.36 2.77e-11 C-reactive protein levels; CRC cis rs6815814 0.950 rs11725779 chr4:38811668 G/A cg06935464 chr4:38784597 TLR10 0.55 5.74 0.3 2.12e-8 Breast cancer; CRC cis rs826838 1.000 rs7299124 chr12:39002661 T/C cg26384229 chr12:38710491 ALG10B 0.72 10.07 0.49 5.64e-21 Heart rate; CRC trans rs35110281 0.712 rs8133523 chr21:45062403 A/G cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.54 9.19 0.45 4.45e-18 Mean corpuscular volume; CRC cis rs8053891 0.615 rs2000999 chr16:72108093 G/A cg01557791 chr16:72042693 DHODH -0.56 -5.84 -0.31 1.28e-8 Coronary artery disease; CRC cis rs3091242 0.781 rs71652378 chr1:25721457 G/C cg23205692 chr1:25664452 TMEM50A 0.4 5.61 0.3 4.24e-8 Erythrocyte sedimentation rate; CRC cis rs7493 1.000 rs2158806 chr7:95051998 A/C cg01874867 chr7:94954059 PON1 -0.51 -6.39 -0.33 5.66e-10 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs9462027 0.606 rs12201281 chr6:34681091 T/C cg07306190 chr6:34760872 UHRF1BP1 0.37 6.63 0.34 1.35e-10 Systemic lupus erythematosus; CRC cis rs2425143 1.000 rs73902914 chr20:34432882 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.51 -6.1 -0.32 3e-9 Blood protein levels; CRC cis rs1355223 0.525 rs55796371 chr11:34872769 T/C cg11058730 chr11:34937778 PDHX;APIP -0.43 -6.08 -0.32 3.26e-9 Systemic lupus erythematosus and Systemic sclerosis; CRC cis rs4073416 0.542 rs1953415 chr14:65988034 A/G cg03016385 chr14:66212404 NA -0.42 -5.93 -0.31 7.71e-9 N-glycan levels; CRC cis rs7131987 0.644 rs1436323 chr12:29554741 A/G cg09582351 chr12:29534625 ERGIC2 0.27 5.74 0.3 2.17e-8 QT interval; CRC cis rs9322193 0.923 rs66516768 chr6:149993135 C/T cg04369109 chr6:150039330 LATS1 -0.41 -5.72 -0.3 2.4e-8 Lung cancer; CRC cis rs10461617 0.531 rs2662033 chr5:56213410 T/G cg18230493 chr5:56204884 C5orf35 -0.8 -11.05 -0.52 2.32e-24 Type 2 diabetes; CRC cis rs11628318 0.614 rs1190338 chr14:103105792 T/G cg08075719 chr14:103021372 NA -0.67 -7.87 -0.4 5.07e-14 Platelet count; CRC cis rs6960043 0.689 rs12538003 chr7:15058692 G/A cg19272540 chr7:15055459 NA 0.23 6.22 0.32 1.55e-9 Type 2 diabetes; CRC cis rs13108904 0.967 rs12502916 chr4:1276349 G/A cg16405210 chr4:1374714 KIAA1530 0.42 5.94 0.31 7.07e-9 Obesity-related traits; CRC cis rs12134245 0.742 rs17501381 chr1:92003919 A/G cg21854759 chr1:92012499 NA -0.52 -8.45 -0.42 9.38e-16 Breast cancer; CRC cis rs2735413 0.918 rs12931394 chr16:78081629 G/A cg04733911 chr16:78082701 NA -0.44 -7.37 -0.38 1.38e-12 Systolic blood pressure (alcohol consumption interaction); CRC cis rs72717009 0.825 rs12722986 chr1:161465420 A/G cg23840854 chr1:161414152 NA -0.66 -7.9 -0.4 4.32e-14 Rheumatoid arthritis; CRC trans rs80346118 0.673 rs6012535 chr20:47423191 G/A cg14297966 chr9:35101708 STOML2 0.45 5.98 0.31 5.89e-9 Diastolic blood pressure; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg09514589 chr15:76603992 ETFA 0.47 6.06 0.32 3.67e-9 Thyroid stimulating hormone; CRC cis rs6089584 0.606 rs2273989 chr20:60579138 G/A cg23463467 chr20:60627584 TAF4 0.38 7.45 0.38 8.36e-13 Body mass index; CRC cis rs9381040 0.599 rs2057001 chr6:41022947 A/G cg09580153 chr6:41068724 NFYA;LOC221442 -0.44 -6.41 -0.33 5.06e-10 Alzheimer's disease (late onset); CRC cis rs10504073 0.647 rs62507252 chr8:50028795 C/G cg00325661 chr8:49890786 NA 0.54 9.58 0.47 2.43e-19 Blood metabolite ratios; CRC cis rs8170 1.000 rs10418362 chr19:17386107 A/T cg04749549 chr19:17459798 NA -0.44 -5.95 -0.31 6.82e-9 Breast cancer (estrogen-receptor negative);Breast Cancer in BRCA1 mutation carriers;Ovarian cancer;Breast cancer;Epithelial ovarian cancer; CRC cis rs11105298 0.891 rs11105325 chr12:89938590 G/A cg00757033 chr12:89920650 WDR51B 0.39 6.31 0.33 9.19e-10 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; CRC cis rs13191362 1.000 rs34653853 chr6:163114362 C/T cg23758597 chr6:163146217 PARK2 -0.67 -6.77 -0.35 6.05e-11 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs4665809 0.590 rs7606351 chr2:26292545 A/C cg04944784 chr2:26401820 FAM59B -0.65 -8.01 -0.4 1.95e-14 Gut microbiome composition (summer); CRC cis rs561341 1.000 rs693116 chr17:30246124 C/T cg00745463 chr17:30367425 LRRC37B -0.88 -9.68 -0.47 1.14e-19 Hip circumference adjusted for BMI; CRC cis rs6740322 0.644 rs11690918 chr2:43474112 T/C cg06169590 chr2:43455088 ZFP36L2;LOC100129726 -0.66 -7.46 -0.38 7.73e-13 Coronary artery disease; CRC cis rs4713118 0.869 rs10214440 chr6:27702440 A/C cg21204522 chr6:27730016 NA -0.4 -5.67 -0.3 3.2e-8 Parkinson's disease; CRC cis rs3733585 0.631 rs4697925 chr4:10124330 G/C cg00071950 chr4:10020882 SLC2A9 -0.52 -8.13 -0.41 8.85e-15 Cleft plate (environmental tobacco smoke interaction); CRC cis rs728616 0.558 rs12767261 chr10:82162323 G/A cg11900509 chr10:81946545 ANXA11 -0.56 -6.24 -0.33 1.32e-9 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs11711311 1.000 rs12695295 chr3:113474866 A/G cg15478005 chr3:113465772 ATP6V1A;NAA50 0.42 5.85 0.31 1.22e-8 IgG glycosylation; CRC cis rs7487075 0.619 rs10880970 chr12:46830420 A/G cg22049899 chr12:47219821 SLC38A4 0.31 5.74 0.3 2.12e-8 Itch intensity from mosquito bite; CRC cis rs713587 0.776 rs1172294 chr2:25169200 A/G cg22495460 chr2:25135724 ADCY3 -0.66 -11.09 -0.52 1.77e-24 Body mass index in non-asthmatics; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg25026703 chr17:78429138 NA 0.37 6.0 0.31 5.06e-9 Liver disease severity in Alagille syndrome; CRC cis rs904251 0.864 rs2797801 chr6:37487161 A/G cg01843034 chr6:37503916 NA -0.48 -8.8 -0.44 7.73e-17 Cognitive performance; CRC trans rs7267979 0.966 rs6107031 chr20:25350677 C/T cg17903999 chr18:56338584 MALT1 0.42 6.94 0.36 2.03e-11 Liver enzyme levels (alkaline phosphatase); CRC cis rs8032158 1.000 rs11632096 chr15:56210499 A/G cg02198044 chr15:56286336 NEDD4 -0.38 -5.74 -0.3 2.1e-8 Keloid; CRC cis rs6502050 0.835 rs4789665 chr17:80168097 A/C cg22110888 chr17:80059540 CCDC57 0.4 6.25 0.33 1.3e-9 Life satisfaction; CRC cis rs4819852 0.958 rs2238786 chr22:19975444 A/G cg07821417 chr22:19972146 ARVCF 0.44 5.97 0.31 6.26e-9 Pulse pressure; CRC cis rs7927771 0.524 rs10838740 chr11:47679980 A/G cg20307385 chr11:47447363 PSMC3 0.45 6.65 0.34 1.21e-10 Subjective well-being; CRC cis rs12928939 0.954 rs34998650 chr16:71829329 T/C cg03805757 chr16:71968109 PKD1L3 -0.47 -6.02 -0.31 4.78e-9 Post bronchodilator FEV1; CRC cis rs2243480 1.000 rs313831 chr7:65551226 C/T cg12463550 chr7:65579703 CRCP 0.67 6.4 0.33 5.2e-10 Diabetic kidney disease; CRC cis rs9916302 0.904 rs4795356 chr17:37535631 C/T cg07936489 chr17:37558343 FBXL20 0.8 12.22 0.56 1.46e-28 Glomerular filtration rate (creatinine); CRC cis rs4638749 0.677 rs1563111 chr2:108845717 A/G cg25838818 chr2:108905173 SULT1C2 -0.34 -5.84 -0.31 1.28e-8 Blood pressure; CRC cis rs4642101 0.618 rs7612317 chr3:12820558 C/T cg24848339 chr3:12840334 CAND2 0.34 6.35 0.33 6.98e-10 QRS complex (12-leadsum); CRC cis rs7666738 0.830 rs13149779 chr4:99010145 G/T cg17366294 chr4:99064904 C4orf37 0.44 7.35 0.38 1.55e-12 Colonoscopy-negative controls vs population controls; CRC cis rs7306456 0.623 rs10902513 chr12:132693487 A/G cg20360395 chr12:132671235 NA 0.38 6.2 0.32 1.72e-9 Anti-saccade response; CRC cis rs7811142 1.000 rs11763511 chr7:100081944 G/A cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.16 17.05 0.68 3.64e-47 Platelet count; CRC cis rs1552244 1.000 rs34179822 chr3:10140017 A/G cg08888203 chr3:10149979 C3orf24 0.67 9.77 0.47 6.02e-20 Alzheimer's disease; CRC cis rs12586317 0.547 rs74462850 chr14:35500093 G/T cg16230307 chr14:35515116 FAM177A1 0.9 10.55 0.5 1.36e-22 Psoriasis; CRC cis rs1707322 0.752 rs28623463 chr1:46170758 A/C cg03146154 chr1:46216737 IPP 0.67 9.73 0.47 7.77e-20 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs933688 0.526 rs2973468 chr5:90540879 A/C cg02339078 chr5:90679543 LOC100129716;ARRDC3 -0.49 -5.91 -0.31 8.42e-9 Smoking behavior; CRC cis rs34375054 0.624 rs4073534 chr12:125671800 C/T cg02766259 chr12:125626809 AACS -0.48 -7.72 -0.39 1.43e-13 Post bronchodilator FEV1/FVC ratio; CRC cis rs9435341 0.965 rs56111229 chr1:107566689 T/A cg14671364 chr1:107599128 PRMT6 0.52 7.19 0.37 4.49e-12 Facial morphology (factor 21, depth of nasal alae); CRC cis rs35000415 0.938 rs12531711 chr7:128617466 A/G cg19972273 chr7:128594194 NA 0.64 5.94 0.31 7.22e-9 Systemic lupus erythematosus; CRC cis rs727563 0.635 rs713988 chr22:42159072 A/G cg06634786 chr22:41940651 POLR3H 0.66 7.27 0.37 2.62e-12 Crohn's disease;Inflammatory bowel disease; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg00184235 chr8:126442434 TRIB1 0.41 6.79 0.35 5.35e-11 Liver disease severity in Alagille syndrome; CRC cis rs9911578 0.935 rs34523895 chr17:57034095 T/C cg05425664 chr17:57184151 TRIM37 -0.44 -6.96 -0.36 1.82e-11 Intelligence (multi-trait analysis); CRC cis rs7107174 0.892 rs2512534 chr11:77970039 T/A cg02023728 chr11:77925099 USP35 0.53 7.54 0.38 4.74e-13 Testicular germ cell tumor; CRC cis rs72945132 0.882 rs57810426 chr11:70230030 G/A cg00319359 chr11:70116639 PPFIA1 0.57 6.19 0.32 1.78e-9 Coronary artery disease; CRC cis rs6963495 0.818 rs6961233 chr7:105150469 C/T cg13798780 chr7:105162888 PUS7 0.66 8.06 0.41 1.39e-14 Bipolar disorder (body mass index interaction); CRC cis rs3806843 0.518 rs173471 chr5:140335226 A/G cg19875535 chr5:140030758 IK 0.4 6.12 0.32 2.64e-9 Depressive symptoms (multi-trait analysis); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg13871588 chr6:42981948 MEA1;KLHDC3 0.41 6.11 0.32 2.74e-9 Intelligence (multi-trait analysis); CRC cis rs868943 0.582 rs12203393 chr6:116461404 C/A cg15226275 chr6:116381976 FRK 0.25 5.87 0.31 1.06e-8 Total cholesterol levels; CRC cis rs72781680 0.898 rs72796171 chr2:23942667 G/C cg08917208 chr2:24149416 ATAD2B 0.89 8.66 0.43 2.19e-16 Lymphocyte counts; CRC cis rs7113874 0.550 rs10840084 chr11:8609274 G/A cg17679104 chr11:8615758 STK33 0.36 6.06 0.32 3.63e-9 Body mass index in physically active individuals;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs6570726 0.791 rs6913727 chr6:145899826 A/G cg23711669 chr6:146136114 FBXO30 0.69 11.52 0.54 4.94e-26 Lobe attachment (rater-scored or self-reported); CRC cis rs1552244 0.572 rs7645759 chr3:10157368 C/T cg13047869 chr3:10149882 C3orf24 0.55 6.6 0.34 1.62e-10 Alzheimer's disease; CRC cis rs427394 0.582 rs274667 chr5:6710771 A/G cg15145174 chr5:6755386 POLS 0.45 6.33 0.33 7.99e-10 Menopause (age at onset); CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg16907344 chr1:16174671 SPEN;FLJ37453 0.44 6.25 0.33 1.26e-9 Anxiety disorder; CRC cis rs769267 0.965 rs2315024 chr19:19423817 T/A cg03709012 chr19:19516395 GATAD2A 0.68 10.42 0.5 3.69e-22 Tonsillectomy; CRC cis rs10751667 0.643 rs10751666 chr11:941933 C/T cg06064525 chr11:970664 AP2A2 -0.31 -6.16 -0.32 2.18e-9 Alzheimer's disease (late onset); CRC cis rs13118159 0.550 rs10016557 chr4:1363628 C/T cg02475777 chr4:1388615 CRIPAK -0.45 -5.73 -0.3 2.26e-8 Longevity; CRC cis rs1975991 0.503 rs9844744 chr3:187980503 G/C cg17585528 chr3:187988060 LPP -0.44 -5.87 -0.31 1.07e-8 White matter integrity (bipolar disorder risk interaction); CRC cis rs763121 0.819 rs5750629 chr22:38985065 T/C cg06022373 chr22:39101656 GTPBP1 0.79 13.17 0.59 4.13e-32 Menopause (age at onset); CRC cis rs6484504 0.600 rs208063 chr11:31159777 C/T cg14844989 chr11:31128820 NA -0.33 -5.92 -0.31 8.25e-9 Red blood cell count; CRC cis rs9814567 1.000 rs934093 chr3:134195885 A/G cg06109529 chr3:134205091 CEP63;ANAPC13 -0.83 -12.75 -0.57 1.61e-30 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs2153535 0.580 rs9406162 chr6:8466196 C/T cg07606381 chr6:8435919 SLC35B3 0.67 10.7 0.51 4.01e-23 Motion sickness; CRC cis rs1046896 0.627 rs7225515 chr17:80795783 C/T cg19500275 chr17:80737654 TBCD 0.5 6.73 0.35 7.77e-11 Glycated hemoglobin levels; CRC trans rs7824557 0.505 rs2736313 chr8:11086942 C/T cg08975724 chr8:8085496 FLJ10661 0.4 5.99 0.31 5.42e-9 Retinal vascular caliber; CRC cis rs1799949 1.000 rs4793229 chr17:41418334 C/T cg05368731 chr17:41323189 NBR1 -0.69 -10.32 -0.49 8.12e-22 Menopause (age at onset); CRC cis rs1401999 1.000 rs4148579 chr3:183685249 T/C cg05044414 chr3:183734942 ABCC5 0.47 8.13 0.41 8.85e-15 Anterior chamber depth; CRC cis rs9814567 1.000 rs6763093 chr3:134254995 C/G cg06109529 chr3:134205091 CEP63;ANAPC13 0.83 12.22 0.56 1.46e-28 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs7221595 0.825 rs10521127 chr17:3978268 A/G cg11204139 chr17:3907470 NA 0.48 6.22 0.32 1.49e-9 Functional impairment in major depressive disorder, bipolar disorder and schizophrenia; CRC cis rs12760731 0.623 rs10465514 chr1:178334035 G/T cg00404053 chr1:178313656 RASAL2 0.75 9.45 0.46 6.61e-19 Obesity-related traits; CRC cis rs870825 0.616 rs57086463 chr4:185639525 G/A cg04058563 chr4:185651563 MLF1IP 0.73 9.41 0.46 9.01e-19 Blood protein levels; CRC trans rs2303319 0.504 rs62189043 chr2:162608466 A/T cg27342122 chr8:133787442 PHF20L1 -0.72 -6.12 -0.32 2.68e-9 Cognitive function; CRC cis rs2239547 0.657 rs12488303 chr3:52862003 G/A cg10802521 chr3:52805072 NEK4 -0.45 -6.0 -0.31 5.32e-9 Schizophrenia; CRC cis rs2075371 0.637 rs13245165 chr7:133951492 A/T cg20476274 chr7:133979776 SLC35B4 0.72 11.95 0.55 1.38e-27 Mean platelet volume; CRC cis rs17253792 0.822 rs75049893 chr14:56089158 A/G cg24579896 chr14:56047964 C14orf33;KTN1 0.71 5.69 0.3 2.81e-8 Putamen volume; CRC cis rs17767392 0.834 rs61991193 chr14:71743789 C/T cg13720639 chr14:72061746 SIPA1L1 -0.5 -6.08 -0.32 3.3e-9 Mitral valve prolapse; CRC cis rs78456975 1.000 rs11898988 chr2:1560336 G/A cg26248373 chr2:1572462 NA -0.66 -7.2 -0.37 4.09e-12 Placebo response in major depressive disorder (% change in symptom score); CRC cis rs8141797 0.901 rs738808 chr22:24488461 C/T cg20894457 chr22:24584366 SUSD2 0.68 6.43 0.33 4.61e-10 Amyotrophic lateral sclerosis;Coronary artery disease; CRC cis rs939584 1.000 rs6749375 chr2:636017 C/T cg03610516 chr2:642275 NA 0.43 5.76 0.3 1.91e-8 Body mass index; CRC cis rs4713118 0.513 rs149944 chr6:28002818 C/T cg21251018 chr6:28226885 NKAPL 0.48 7.63 0.39 2.57e-13 Parkinson's disease; CRC cis rs6951245 1.000 rs113858334 chr7:1073476 A/G cg03188948 chr7:1209495 NA 0.63 6.52 0.34 2.64e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs13108904 0.935 rs1732100 chr4:1281761 C/T cg02018176 chr4:1364513 KIAA1530 -0.44 -7.43 -0.38 9.44e-13 Obesity-related traits; CRC cis rs12541635 0.967 rs11997513 chr8:107093325 C/T cg10147462 chr8:107024639 NA -0.38 -6.31 -0.33 9.22e-10 Age of smoking initiation; CRC cis rs1997103 0.834 rs10274457 chr7:55390199 G/A cg17469321 chr7:55412551 NA 0.74 11.48 0.53 7.1e-26 QRS interval (sulfonylurea treatment interaction); CRC cis rs561341 1.000 rs693116 chr17:30246124 C/T cg19193384 chr17:30244184 NA -0.63 -7.17 -0.37 5.09e-12 Hip circumference adjusted for BMI; CRC trans rs2727020 0.576 rs12293522 chr11:49558425 T/A cg15704280 chr7:45808275 SEPT13 -0.94 -18.08 -0.71 3.26e-51 Coronary artery disease; CRC cis rs2242116 0.796 rs9852082 chr3:46972377 T/C cg02527881 chr3:46936655 PTH1R -0.49 -8.74 -0.43 1.19e-16 Birth weight; CRC trans rs9329221 0.683 rs555200 chr8:9888729 A/G cg06636001 chr8:8085503 FLJ10661 -0.53 -8.28 -0.42 3.2e-15 Neuroticism; CRC cis rs904251 0.561 rs1757189 chr6:37483727 G/C cg25019722 chr6:37503610 NA -0.41 -7.37 -0.38 1.4e-12 Cognitive performance; CRC cis rs10504229 1.000 rs77823122 chr8:58170161 A/G cg02290350 chr8:58132656 NA -0.42 -5.96 -0.31 6.62e-9 Developmental language disorder (linguistic errors); CRC cis rs6502050 0.835 rs4789670 chr17:80151805 T/C cg02741985 chr17:80059408 CCDC57 0.44 7.29 0.37 2.34e-12 Life satisfaction; CRC cis rs8078723 0.738 rs3816472 chr17:38142677 A/C cg17467752 chr17:38218738 THRA -0.57 -8.93 -0.44 3.12e-17 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); CRC cis rs12024301 0.557 rs16861402 chr1:183620178 C/T cg11505048 chr1:183622726 RGL1;APOBEC4 0.81 7.14 0.37 5.93e-12 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs881375 0.678 rs10760130 chr9:123701990 G/A cg09419670 chr9:123605666 PSMD5;LOC253039 0.5 7.97 0.4 2.61e-14 Rheumatoid arthritis; CRC cis rs2404602 0.647 rs12905181 chr15:77098431 A/G cg03037974 chr15:76606532 NA -0.54 -8.23 -0.41 4.33e-15 Blood metabolite levels; CRC cis rs6088580 0.634 rs2225837 chr20:33005634 C/T cg24642439 chr20:33292090 TP53INP2 -0.37 -6.36 -0.33 6.71e-10 Glomerular filtration rate (creatinine); CRC cis rs4889855 0.614 rs6565694 chr17:78501101 T/C cg16591659 chr17:78472290 NA -0.61 -7.54 -0.38 4.48e-13 Fractional excretion of uric acid; CRC cis rs10504229 0.609 rs66477547 chr8:58105763 A/C cg04204079 chr8:58130323 NA -0.47 -5.89 -0.31 9.76e-9 Developmental language disorder (linguistic errors); CRC cis rs9921222 0.565 rs10903014 chr16:377623 A/G cg26944245 chr16:421049 TMEM8A;MRPL28 0.44 6.65 0.34 1.22e-10 Bone mineral density (spine);Bone mineral density; CRC cis rs10208940 0.920 rs10164780 chr2:68766250 A/T cg12452813 chr2:68675892 NA 0.48 6.01 0.31 4.94e-9 Urate levels in lean individuals; CRC cis rs35110281 0.837 rs7279968 chr21:45077398 C/G cg01579765 chr21:45077557 HSF2BP -0.37 -7.19 -0.37 4.31e-12 Mean corpuscular volume; CRC cis rs7659604 1.000 rs35901586 chr4:122664757 T/A cg20573242 chr4:122745356 CCNA2 0.4 6.01 0.31 4.92e-9 Type 2 diabetes; CRC cis rs6502050 0.865 rs8079388 chr17:80162798 C/A cg09264619 chr17:80180166 NA -0.34 -5.62 -0.3 4.03e-8 Life satisfaction; CRC cis rs9660180 0.967 rs2272908 chr1:1721479 A/G cg23982607 chr1:1823379 GNB1 0.84 15.25 0.64 4.31e-40 Body mass index; CRC cis rs2811415 0.597 rs13092555 chr3:127738638 T/A cg13719885 chr3:127795394 NA -0.4 -6.06 -0.32 3.67e-9 Lung function (FEV1/FVC); CRC cis rs35306767 0.903 rs35957139 chr10:884889 C/T cg26597838 chr10:835615 NA 1.28 14.87 0.63 1.28e-38 Eosinophil percentage of granulocytes; CRC cis rs7590720 0.840 rs705648 chr2:216933792 C/T cg12620499 chr2:216877984 MREG 0.73 10.19 0.49 2.29e-21 Alcohol dependence; CRC cis rs8177253 0.965 rs1525889 chr3:133490033 A/C cg08048268 chr3:133502702 NA -0.38 -7.15 -0.37 5.58e-12 Iron status biomarkers; CRC cis rs6456156 0.805 rs6909252 chr6:167527097 C/T cg19688584 chr6:167529678 CCR6 -0.36 -6.53 -0.34 2.52e-10 Primary biliary cholangitis; CRC cis rs4713118 0.621 rs4713134 chr6:28034121 T/C cg12172441 chr6:28176163 NA 0.59 7.19 0.37 4.51e-12 Parkinson's disease; CRC cis rs7811142 1.000 rs60844404 chr7:100080474 A/T cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.6 7.7 0.39 1.62e-13 Platelet count; CRC cis rs3820068 0.603 rs932602 chr1:15986087 A/G cg27534772 chr1:16042836 PLEKHM2 0.55 10.42 0.5 3.63e-22 Systolic blood pressure; CRC cis rs2730245 0.505 rs1188956 chr7:158690576 G/A cg01943577 chr7:158741284 NA -0.44 -6.4 -0.33 5.39e-10 Height; CRC cis rs853679 0.882 rs9380069 chr6:28203300 A/G cg15845792 chr6:28175446 NA 0.67 5.67 0.3 3.13e-8 Depression; CRC cis rs1577917 1.000 rs10944163 chr6:86658693 T/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.58 -7.21 -0.37 3.81e-12 Response to antipsychotic treatment; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg17465130 chr10:135192054 PAOX 0.47 6.77 0.35 6.03e-11 Response to antipsychotic treatment; CRC trans rs1814175 0.645 rs10128563 chr11:50023681 T/C cg03929089 chr4:120376271 NA -0.88 -15.84 -0.66 2.09e-42 Height; CRC cis rs690037 0.551 rs690522 chr3:16377067 C/T cg23474789 chr3:16306055 DPH3;OXNAD1 -0.43 -5.78 -0.3 1.73e-8 Optic nerve measurement (cup-to-disc ratio);Optic nerve measurement (cup area); CRC cis rs7666738 0.747 rs2865955 chr4:99040518 A/C cg05340658 chr4:99064831 C4orf37 0.6 9.45 0.46 6.36e-19 Colonoscopy-negative controls vs population controls; CRC cis rs17270561 0.609 rs9358887 chr6:25759406 G/T cg16482183 chr6:26056742 HIST1H1C 0.74 9.06 0.45 1.22e-17 Iron status biomarkers; CRC cis rs875971 0.861 rs801215 chr7:66011938 A/T cg00343986 chr7:65444356 GUSB -0.45 -6.27 -0.33 1.15e-9 Aortic root size; CRC cis rs9467711 0.591 rs3752417 chr6:26045905 G/C cg19084075 chr6:26124329 HIST1H2AC;HIST1H2BC 0.75 6.53 0.34 2.5e-10 Autism spectrum disorder or schizophrenia; CRC trans rs6015450 1.000 rs74715624 chr20:57753203 T/C cg22122715 chr13:96086023 CLDN10 -0.55 -6.07 -0.32 3.48e-9 Diastolic blood pressure;Systolic blood pressure;Hypertension;Blood pressure; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg07036775 chr1:145470395 ANKRD34A;POLR3GL 0.43 5.97 0.31 6.19e-9 Intelligence (multi-trait analysis); CRC cis rs10924970 0.967 rs4659654 chr1:235383188 A/G cg26050004 chr1:235667680 B3GALNT2 0.39 5.82 0.31 1.43e-8 Asthma; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg27488370 chr7:128046294 IMPDH1 -0.41 -6.16 -0.32 2.12e-9 Liver disease severity in Alagille syndrome; CRC cis rs4728302 0.869 rs13233715 chr7:133617471 C/T cg10665199 chr7:133106180 EXOC4 0.38 5.76 0.3 1.92e-8 Intelligence;Intelligence (multi-trait analysis); CRC cis rs10504229 0.728 rs72650853 chr8:58151473 G/A cg05313129 chr8:58192883 C8orf71 -0.47 -6.18 -0.32 1.94e-9 Developmental language disorder (linguistic errors); CRC cis rs2573652 1.000 rs1469829 chr15:100517332 A/G cg00587665 chr15:100533223 ADAMTS17 -0.37 -6.42 -0.33 4.66e-10 Height; CRC cis rs7809950 0.954 rs2712229 chr7:107295326 T/A cg23024343 chr7:107201750 COG5 0.48 6.88 0.35 2.99e-11 Coronary artery disease; CRC cis rs4930103 0.935 rs2075744 chr11:2018449 A/G cg06197492 chr11:2016605 H19 0.41 6.38 0.33 6.15e-10 DNA methylation (parent-of-origin);DNA methylation (variation); CRC cis rs11249608 0.548 rs2132671 chr5:178457434 A/G cg01312482 chr5:178451176 ZNF879 0.34 5.72 0.3 2.45e-8 Pubertal anthropometrics; CRC cis rs7666738 0.830 rs969048 chr4:98988921 T/C cg05340658 chr4:99064831 C4orf37 0.61 9.54 0.47 3.21e-19 Colonoscopy-negative controls vs population controls; CRC cis rs4474465 1.000 rs2063726 chr11:78183533 T/C cg27205649 chr11:78285834 NARS2 -0.48 -5.8 -0.3 1.57e-8 Alzheimer's disease (survival time); CRC cis rs2836950 0.565 rs2836942 chr21:40591381 A/G cg11890956 chr21:40555474 PSMG1 -0.66 -9.92 -0.48 1.8899999999999998e-20 Menarche (age at onset); CRC cis rs17401966 0.540 rs4846221 chr1:10472026 C/A cg19773385 chr1:10388646 KIF1B -0.48 -7.58 -0.39 3.64e-13 Hepatocellular carcinoma; CRC cis rs877282 0.853 rs12779017 chr10:763619 T/C cg06581033 chr10:766294 NA -0.52 -5.78 -0.3 1.71e-8 Uric acid levels; CRC cis rs8103278 1.000 rs1548029 chr19:46309203 A/C cg20908204 chr19:46285434 DMPK -0.34 -6.84 -0.35 3.97e-11 Coronary artery disease; CRC trans rs7618501 1.000 rs3749240 chr3:49750188 T/A cg21665057 chr3:196295764 WDR53;FBXO45 -0.85 -15.78 -0.66 3.69e-42 Intelligence (multi-trait analysis); CRC cis rs7949030 0.653 rs17773169 chr11:62318530 G/T cg11742103 chr11:62369870 EML3;MTA2 0.61 11.98 0.55 1.11e-27 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; CRC cis rs2456568 0.867 rs10501810 chr11:93666589 C/G cg26875233 chr11:93583750 C11orf90 -0.33 -6.27 -0.33 1.11e-9 Response to serotonin reuptake inhibitors in major depressive disorder; CRC cis rs3806843 0.900 rs2337984 chr5:140136811 G/A cg19875535 chr5:140030758 IK -0.61 -9.84 -0.48 3.32e-20 Depressive symptoms (multi-trait analysis); CRC cis rs853679 0.517 rs4713146 chr6:28111536 A/T cg15786705 chr6:28176104 NA 0.78 9.83 0.48 3.57e-20 Depression; CRC cis rs995000 0.931 rs1168042 chr1:62974150 A/T cg19896129 chr1:63156450 NA -0.45 -6.99 -0.36 1.5e-11 Triglyceride levels; CRC cis rs6988636 1.000 rs13260318 chr8:124190165 C/G cg27053337 chr8:124217698 FAM83A 0.43 6.59 0.34 1.74e-10 Urinary uromodulin levels; CRC cis rs12474201 0.507 rs6714451 chr2:47017743 G/C cg06386533 chr2:46925753 SOCS5 0.49 6.91 0.36 2.58e-11 Height; CRC cis rs4713118 0.955 rs9368528 chr6:27683798 G/A cg26587870 chr6:27730563 NA -0.42 -6.28 -0.33 1.05e-9 Parkinson's disease; CRC cis rs6952808 0.609 rs10227517 chr7:1950292 A/T cg14004847 chr7:1930337 MAD1L1 -0.41 -6.0 -0.31 5.12e-9 Bipolar disorder and schizophrenia; CRC cis rs7772486 0.790 rs2250387 chr6:146205233 C/T cg13319975 chr6:146136371 FBXO30 -0.38 -5.76 -0.3 1.9e-8 Lobe attachment (rater-scored or self-reported); CRC trans rs4688759 0.764 rs11716961 chr3:49908338 G/A cg01304814 chr3:48885189 PRKAR2A 0.94 6.36 0.33 6.7e-10 Blood protein levels; CRC cis rs775227 0.574 rs3732809 chr3:113045561 A/G cg18753928 chr3:113234510 CCDC52 -0.53 -6.61 -0.34 1.56e-10 Dental caries; CRC cis rs7945705 0.875 rs2568065 chr11:8889648 C/T cg12365402 chr11:9010492 NRIP3 -0.48 -8.04 -0.41 1.59e-14 Hemoglobin concentration; CRC cis rs1448094 0.512 rs61930137 chr12:86242930 C/T cg19622623 chr12:86230825 RASSF9 -0.41 -6.7 -0.35 9.04e-11 Major depressive disorder; CRC cis rs7945705 0.967 rs1569408 chr11:8909732 G/A cg14711859 chr11:8959438 ASCL3 -0.52 -8.42 -0.42 1.16e-15 Hemoglobin concentration; CRC cis rs826838 1.000 rs1684416 chr12:39130301 G/A cg13010199 chr12:38710504 ALG10B -0.41 -5.84 -0.31 1.27e-8 Heart rate; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg07702255 chr11:46143461 PHF21A 0.41 6.08 0.32 3.35e-9 Intelligence (multi-trait analysis); CRC cis rs2832191 0.626 rs2254796 chr21:30341891 A/G cg24692254 chr21:30365293 RNF160 -0.85 -15.77 -0.66 4.06e-42 Dental caries; CRC cis rs1862618 0.853 rs2113079 chr5:56157951 A/G cg20203395 chr5:56204925 C5orf35 -0.7 -8.54 -0.43 5.2e-16 Initial pursuit acceleration; CRC trans rs1864729 1.000 rs2567773 chr8:98279182 G/A cg08679828 chr8:102218111 ZNF706 -0.58 -7.05 -0.36 1.06e-11 Estradiol plasma levels (breast cancer); CRC cis rs10504229 1.000 rs68112919 chr8:58188247 G/A cg02290350 chr8:58132656 NA -0.42 -5.94 -0.31 7.26e-9 Developmental language disorder (linguistic errors); CRC cis rs7487075 0.828 rs7132228 chr12:46731961 G/A cg22049899 chr12:47219821 SLC38A4 0.35 6.82 0.35 4.45e-11 Itch intensity from mosquito bite; CRC cis rs2996428 0.561 rs72640913 chr1:3747023 C/G cg13057898 chr1:3703894 LRRC47 0.58 7.81 0.4 7.7e-14 Red cell distribution width; CRC cis rs12410462 0.901 rs16847844 chr1:227638110 A/G cg04117972 chr1:227635322 NA 0.62 7.24 0.37 3.24e-12 Major depressive disorder; CRC cis rs7847628 0.765 rs7026635 chr9:123550027 A/G cg09419670 chr9:123605666 PSMD5;LOC253039 -0.72 -9.4 -0.46 9.79e-19 Birth weight; CRC cis rs812925 0.511 rs11886950 chr2:61399317 A/C cg10580144 chr2:61372316 C2orf74 0.34 7.69 0.39 1.7e-13 Immature fraction of reticulocytes; CRC cis rs9879311 0.932 rs7427473 chr3:10413197 C/T cg11030744 chr3:10328490 GHRL;GHRLOS 0.37 5.7 0.3 2.68e-8 Schizophrenia;Autism spectrum disorder or schizophrenia; CRC cis rs9549328 0.837 rs9549618 chr13:113628648 G/A cg25790453 chr13:113633590 MCF2L -0.57 -10.09 -0.49 5.03e-21 Systolic blood pressure; CRC cis rs11098499 0.754 rs2036860 chr4:120248934 A/G cg24375607 chr4:120327624 NA 0.48 7.61 0.39 2.88e-13 Corneal astigmatism; CRC cis rs9914988 0.778 rs35398767 chr17:27122960 A/T cg20469991 chr17:27169893 C17orf63 -0.6 -7.27 -0.37 2.59e-12 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg25382265 chr19:50169375 BCL2L12;IRF3 0.43 6.01 0.31 4.79e-9 Response to antipsychotic treatment; CRC cis rs7621025 0.500 rs4678275 chr3:136653683 C/T cg15507776 chr3:136538369 TMEM22 0.43 6.72 0.35 7.86e-11 C-reactive protein levels or HDL-cholesterol levels (pleiotropy);Body mass index; CRC cis rs16852403 0.548 rs482269 chr1:178226624 T/C cg00404053 chr1:178313656 RASAL2 -0.5 -6.57 -0.34 1.92e-10 Childhood ear infection; CRC cis rs4073416 0.527 rs1959144 chr14:65946051 T/G cg03016385 chr14:66212404 NA -0.45 -6.21 -0.32 1.56e-9 N-glycan levels; CRC cis rs4665809 0.556 rs4665322 chr2:26434605 C/G cg27170947 chr2:26402098 FAM59B -0.65 -8.75 -0.43 1.12e-16 Gut microbiome composition (summer); CRC cis rs17253792 0.822 rs13379353 chr14:56050478 G/C cg24579896 chr14:56047964 C14orf33;KTN1 0.68 5.79 0.3 1.68e-8 Putamen volume; CRC cis rs8077889 0.956 rs61608877 chr17:41848713 A/C cg25876840 chr17:41920477 NA 0.44 6.45 0.33 4.07e-10 Triglycerides; CRC cis rs17767392 1.000 rs34528131 chr14:71861278 C/T cg13720639 chr14:72061746 SIPA1L1 -0.54 -6.89 -0.35 2.93e-11 Mitral valve prolapse; CRC cis rs6831352 1.000 rs6831352 chr4:100063525 T/C cg12011299 chr4:100065546 ADH4 0.54 11.14 0.52 1.12e-24 Alcohol dependence; CRC cis rs968567 0.638 rs7943728 chr11:61547068 G/A cg10868875 chr11:61596307 FADS2 -0.53 -6.86 -0.35 3.41e-11 Blood metabolite levels;Rheumatoid arthritis;Vitiligo;Glycerophospholipid levels; CRC cis rs2204008 0.811 rs11525004 chr12:38333807 T/A cg26384229 chr12:38710491 ALG10B 0.68 9.51 0.46 4.14e-19 Bladder cancer; CRC cis rs3796352 1.000 rs34244302 chr3:53102236 C/G cg07884673 chr3:53033167 SFMBT1 0.76 6.13 0.32 2.45e-9 Immune reponse to smallpox (secreted IL-2); CRC cis rs9399137 0.507 rs11758774 chr6:135383789 T/G cg22676075 chr6:135203613 NA 0.6 8.86 0.44 5.24e-17 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; CRC cis rs970548 1.000 rs11239545 chr10:46012245 A/T cg15590007 chr10:45870220 ALOX5 -0.46 -5.92 -0.31 7.89e-9 Total cholesterol levels;Cholesterol, total;HDL cholesterol;HDL cholesterol levels; CRC cis rs13323323 0.691 rs9815769 chr3:44663014 A/T cg10263370 chr3:44754102 ZNF502 -0.42 -5.78 -0.3 1.74e-8 IgG glycosylation; CRC cis rs10504229 0.683 rs17194995 chr8:58109220 A/C cg21724239 chr8:58056113 NA -0.69 -8.68 -0.43 1.89e-16 Developmental language disorder (linguistic errors); CRC cis rs7949030 0.626 rs11231141 chr11:62326265 T/C cg22862634 chr11:62369728 EML3;MTA2 0.57 10.21 0.49 1.9e-21 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; CRC cis rs11212617 1.000 rs227094 chr11:108233800 C/A cg01991180 chr11:108092276 ATM;NPAT 0.45 6.71 0.35 8.52e-11 Response to metformin in type 2 diabetes (glycemic); CRC cis rs6061231 1.000 rs6061231 chr20:60956917 C/A cg24112000 chr20:60950667 NA -0.64 -10.44 -0.5 3.11e-22 Colorectal cancer; CRC cis rs617791 0.530 rs735942 chr11:65749337 A/G cg09783858 chr11:65769428 EIF1AD;BANF1 0.48 7.27 0.37 2.69e-12 Breast cancer; CRC cis rs364477 0.855 rs279894 chr9:968334 G/A cg13952963 chr9:998547 NA 0.58 6.28 0.33 1.06e-9 Major depressive disorder; CRC cis rs7618915 0.547 rs11720432 chr3:52672742 T/C cg07507251 chr3:52567010 NT5DC2 0.46 6.56 0.34 2.03e-10 Bipolar disorder; CRC cis rs7618915 0.501 rs3774366 chr3:52641255 T/C cg15147215 chr3:52552868 STAB1 -0.63 -10.84 -0.51 1.32e-23 Bipolar disorder; CRC cis rs7647973 0.626 rs35129566 chr3:49866584 T/G cg03060546 chr3:49711283 APEH -0.66 -7.99 -0.4 2.28e-14 Menarche (age at onset); CRC cis rs754466 0.580 rs12354903 chr10:79536465 T/C cg26805224 chr10:79626177 DLG5 -0.48 -7.09 -0.36 8.5e-12 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs28386778 0.897 rs2854221 chr17:61941445 G/T cg23090583 chr17:61904693 PSMC5;FTSJ3 1.03 20.22 0.74 1.2e-59 Prudent dietary pattern; CRC cis rs9341808 0.690 rs6930534 chr6:80896050 C/T cg08355045 chr6:80787529 NA 0.43 6.95 0.36 1.94e-11 Sitting height ratio; CRC cis rs454510 0.542 rs10754417 chr1:120177454 G/T cg11530693 chr1:120165357 ZNF697 0.43 6.22 0.32 1.48e-9 Alcohol dependence or chronic alcoholic pancreatitis or alcohol-related liver cirrhosis; CRC cis rs7089973 0.604 rs3758603 chr10:116605368 T/C cg23260525 chr10:116636907 FAM160B1 0.35 8.11 0.41 1.04e-14 Bipolar disorder or attention deficit hyperactivity disorder; CRC cis rs9467711 0.659 rs35277236 chr6:26562269 G/T cg16898833 chr6:26189333 HIST1H4D 1.14 8.46 0.42 8.89e-16 Autism spectrum disorder or schizophrenia; CRC cis rs7607369 0.536 rs12623740 chr2:219665715 T/A cg02176678 chr2:219576539 TTLL4 -0.38 -6.03 -0.32 4.36e-9 Red blood cell count;Amyotrophic lateral sclerosis; CRC cis rs12220238 0.818 rs115350439 chr10:75899365 C/T cg19889307 chr10:75911429 ADK;AP3M1 0.63 6.11 0.32 2.8e-9 Soluble interleukin-2 receptor subunit alpha; CRC cis rs6502050 0.871 rs8082577 chr17:80070581 T/C cg02741985 chr17:80059408 CCDC57 -0.42 -6.77 -0.35 5.8e-11 Life satisfaction; CRC cis rs9814567 0.806 rs1880374 chr3:134322113 G/A cg06109529 chr3:134205091 CEP63;ANAPC13 -0.68 -10.11 -0.49 4.15e-21 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs7937682 0.640 rs587010 chr11:111425658 C/A cg19812747 chr11:111475976 SIK2 -0.47 -7.77 -0.39 9.89e-14 Primary sclerosing cholangitis; CRC cis rs6977660 0.714 rs12700077 chr7:19791607 A/G cg07541023 chr7:19748670 TWISTNB -0.59 -5.94 -0.31 7.37e-9 Thyroid stimulating hormone; CRC cis rs4819052 0.851 rs2838864 chr21:46711474 A/T cg11663144 chr21:46675770 NA 0.75 12.58 0.57 6.82e-30 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs7119 0.717 rs62009070 chr15:77817884 G/C cg10437265 chr15:77819839 NA 0.69 12.74 0.57 1.76e-30 Type 2 diabetes; CRC cis rs4988958 0.584 rs7589142 chr2:103024660 T/C cg03938978 chr2:103052716 IL18RAP 0.59 10.17 0.49 2.68e-21 Asthma (childhood onset); CRC cis rs67311347 0.911 rs6776044 chr3:40377503 T/G cg24209194 chr3:40518798 ZNF619 0.41 6.1 0.32 2.94e-9 Renal cell carcinoma; CRC trans rs11148252 0.557 rs9536223 chr13:53233194 A/T cg18335740 chr13:41363409 SLC25A15 0.75 13.53 0.6 1.74e-33 Lewy body disease; CRC cis rs17711722 0.522 rs4642526 chr7:65216742 G/T cg18876405 chr7:65276391 NA 0.54 9.02 0.45 1.65e-17 Calcium levels; CRC cis rs713477 0.967 rs8009706 chr14:55914756 A/G cg21836586 chr14:55907198 TBPL2 0.31 5.62 0.3 4.1e-8 Pediatric bone mineral content (femoral neck); CRC cis rs713587 0.646 rs2384061 chr2:25135620 C/T cg22495460 chr2:25135724 ADCY3 -0.99 -22.82 -0.78 8.91e-70 Body mass index in non-asthmatics; CRC cis rs990171 1.000 rs2058660 chr2:103054449 G/A cg03938978 chr2:103052716 IL18RAP 0.46 5.91 0.31 8.41e-9 Lymphocyte counts; CRC cis rs7762018 0.607 rs7759404 chr6:170135728 A/G cg19338460 chr6:170058176 WDR27 -0.69 -7.6 -0.39 3.03e-13 Thiazide-induced adverse metabolic effects in hypertensive patients; CRC trans rs629535 0.814 rs78813708 chr8:70073977 A/G cg21567404 chr3:27674614 NA 0.92 15.32 0.65 2.38e-40 Dupuytren's disease; CRC cis rs10504073 0.647 rs10504072 chr8:49993083 G/A cg00325661 chr8:49890786 NA 0.52 9.23 0.45 3.37e-18 Blood metabolite ratios; CRC cis rs6585424 1.000 rs12769115 chr10:81933501 G/A cg11900509 chr10:81946545 ANXA11 -0.76 -9.31 -0.46 1.92e-18 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs10504229 0.683 rs949856 chr8:58144496 G/A cg22535103 chr8:58192502 C8orf71 -0.7 -9.37 -0.46 1.19e-18 Developmental language disorder (linguistic errors); CRC cis rs3008870 0.583 rs3008861 chr1:67396222 T/G cg08660285 chr1:67390436 MIER1;WDR78 1.02 12.26 0.56 9.9e-29 Lymphocyte percentage of white cells; CRC cis rs4953318 0.694 rs3768747 chr2:46352058 G/T cg12428440 chr2:46370979 PRKCE -0.39 -5.87 -0.31 1.09e-8 Red blood cell count;Hematocrit;Red blood cell traits; CRC cis rs8141529 0.673 rs132548 chr22:29317559 C/G cg15103426 chr22:29168792 CCDC117 -0.44 -6.21 -0.32 1.57e-9 Lymphocyte counts; CRC cis rs8078723 1.000 rs4795418 chr17:38164851 T/C cg17344932 chr17:38183730 MED24;SNORD124 -0.45 -6.98 -0.36 1.62e-11 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); CRC cis rs6546324 1.000 rs1430787 chr2:67868498 A/T cg15745817 chr2:67799979 NA -0.29 -5.7 -0.3 2.7e-8 Endometriosis; CRC cis rs1862618 0.671 rs72644088 chr5:56241019 G/A cg20203395 chr5:56204925 C5orf35 0.57 7.78 0.39 9.41e-14 Initial pursuit acceleration; CRC cis rs3785574 0.962 rs2665842 chr17:61878535 G/A cg11494091 chr17:61959527 GH2 0.38 5.95 0.31 6.73e-9 Height; CRC cis rs7274811 0.681 rs291705 chr20:31969658 A/G cg03904042 chr20:32255491 NECAB3;C20orf134 -0.4 -6.02 -0.32 4.58e-9 Height; CRC cis rs17767392 0.834 rs61991191 chr14:71739204 T/C cg13720639 chr14:72061746 SIPA1L1 -0.53 -6.46 -0.34 3.77e-10 Mitral valve prolapse; CRC cis rs4660306 0.677 rs1691217 chr1:45900190 T/C cg03123370 chr1:45965343 CCDC163P;MMACHC 0.5 6.72 0.35 8.12e-11 Homocysteine levels; CRC cis rs6804368 0.531 rs12107637 chr3:30758448 T/C cg06106510 chr3:30762233 NA 0.39 6.42 0.33 4.77e-10 Blood metabolite levels; CRC cis rs806215 0.950 rs2073561 chr7:127227769 G/C cg25922125 chr7:127225783 GCC1 -0.71 -7.48 -0.38 6.99e-13 Type 2 diabetes; CRC cis rs4423214 0.840 rs1790341 chr11:71177578 T/C cg05163923 chr11:71159392 DHCR7 -0.64 -7.64 -0.39 2.32e-13 Vitamin D levels; CRC cis rs728616 0.510 rs61860860 chr10:81758572 G/A cg05935833 chr10:81318306 SFTPA2 -0.55 -7.16 -0.37 5.14e-12 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs7829975 0.714 rs7823757 chr8:8670177 T/A cg08975724 chr8:8085496 FLJ10661 0.47 7.16 0.37 5.18e-12 Mood instability; CRC cis rs6754311 0.773 rs632632 chr2:136638216 A/G cg15123519 chr2:136567270 LCT -0.35 -6.78 -0.35 5.71e-11 Mosquito bite size; CRC cis rs1862618 0.802 rs832547 chr5:56183941 C/G cg22800045 chr5:56110881 MAP3K1 0.62 6.64 0.34 1.29e-10 Initial pursuit acceleration; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg10118547 chr2:206547064 NRP2 0.39 6.36 0.33 6.83e-10 Liver disease severity in Alagille syndrome; CRC cis rs34638657 0.536 rs2967327 chr16:82188657 C/T cg07918374 chr16:82182319 MPHOSPH6 0.44 6.43 0.33 4.46e-10 Lung adenocarcinoma; CRC cis rs8005677 0.828 rs12437151 chr14:23372913 G/A cg25600027 chr14:23388339 RBM23 -0.43 -6.46 -0.34 3.78e-10 Cognitive ability (multi-trait analysis); CRC cis rs172166 0.637 rs1233691 chr6:28153897 T/G cg12172441 chr6:28176163 NA 0.6 8.57 0.43 4.23e-16 Cardiac Troponin-T levels; CRC cis rs7394190 0.748 rs11000764 chr10:75506864 A/G cg07699608 chr10:75541558 CHCHD1 0.62 6.37 0.33 6.37e-10 Incident atrial fibrillation; CRC cis rs3617 0.573 rs9880978 chr3:52923251 C/G cg18099408 chr3:52552593 STAB1 -0.35 -6.02 -0.31 4.7e-9 Red blood cell count;Autism spectrum disorder or schizophrenia; CRC cis rs10504229 1.000 rs67594249 chr8:58180521 T/A cg02725872 chr8:58115012 NA -0.38 -6.43 -0.33 4.44e-10 Developmental language disorder (linguistic errors); CRC cis rs3617 0.625 rs11715347 chr3:52883070 C/T cg18099408 chr3:52552593 STAB1 0.34 5.81 0.31 1.46e-8 Red blood cell count;Autism spectrum disorder or schizophrenia; CRC cis rs1129187 0.755 rs9462856 chr6:42926024 T/C cg27588902 chr6:42928151 GNMT -0.41 -7.41 -0.38 1.06e-12 Alzheimer's disease in APOE e4+ carriers; CRC cis rs7552404 0.655 rs1146646 chr1:76265500 G/A cg03433033 chr1:76189801 ACADM 0.69 9.71 0.47 9.26e-20 Blood metabolite levels;Acylcarnitine levels; CRC cis rs477692 0.905 rs693402 chr10:131422882 G/A cg05714579 chr10:131428358 MGMT 0.62 9.06 0.45 1.2e-17 Response to temozolomide; CRC cis rs6951245 1.000 rs79683221 chr7:1096139 A/G cg22907277 chr7:1156413 C7orf50 0.72 7.6 0.39 3.1400000000000003e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs2976388 1.000 rs2976398 chr8:143764879 G/C cg24046110 chr8:143859143 LYNX1 -0.39 -6.72 -0.35 7.84e-11 Urinary tract infection frequency; CRC cis rs6545883 0.931 rs778756 chr2:61781994 A/G cg15711740 chr2:61764176 XPO1 -0.4 -5.68 -0.3 2.91e-8 Tuberculosis; CRC cis rs11249608 0.636 rs6868893 chr5:178449826 C/A cg01312482 chr5:178451176 ZNF879 -0.36 -5.97 -0.31 6.26e-9 Pubertal anthropometrics; CRC trans rs9329221 0.683 rs658385 chr8:9892177 C/T cg06636001 chr8:8085503 FLJ10661 -0.5 -7.7 -0.39 1.64e-13 Neuroticism; CRC cis rs9649213 0.593 rs3779194 chr7:98010277 A/G cg08684580 chr7:98029266 BAIAP2L1 -0.31 -5.62 -0.3 4.12e-8 Prostate cancer (SNP x SNP interaction); CRC cis rs9322817 0.691 rs2168394 chr6:105259152 C/T cg02098413 chr6:105308735 HACE1 -0.44 -8.6 -0.43 3.29e-16 Thyroid stimulating hormone; CRC cis rs9992667 0.910 rs17428945 chr4:38689745 T/C cg19726192 chr4:38663646 FLJ13197 -0.7 -8.8 -0.44 7.71e-17 Eosinophil percentage of granulocytes; CRC cis rs35000415 0.938 rs13236009 chr7:128663173 T/G cg19972273 chr7:128594194 NA 0.68 6.32 0.33 8.52e-10 Systemic lupus erythematosus; CRC cis rs12701220 0.503 rs12702024 chr7:1129820 G/C cg04498913 chr7:1135747 C7orf50 -0.61 -6.93 -0.36 2.21e-11 Bronchopulmonary dysplasia; CRC trans rs116095464 0.558 rs7703803 chr5:292311 A/G cg00938859 chr5:1591904 SDHAP3 0.73 7.72 0.39 1.45e-13 Breast cancer; CRC cis rs853679 0.517 rs1904841 chr6:28108085 C/T cg15786705 chr6:28176104 NA 0.76 9.49 0.46 4.97e-19 Depression; CRC cis rs3026101 0.671 rs929262 chr17:5312271 A/G cg25236894 chr17:5323110 RPAIN;NUP88 0.42 6.9 0.36 2.74e-11 Body mass index; CRC cis rs2290405 1.000 rs2290405 chr4:946974 A/G cg08222618 chr4:941054 TMEM175 -0.35 -6.23 -0.32 1.44e-9 Systemic sclerosis; CRC cis rs7677751 0.806 rs7673027 chr4:55096180 T/A cg00691999 chr4:55094011 PDGFRA 0.42 6.03 0.32 4.4e-9 Corneal astigmatism; CRC cis rs7212938 0.509 rs62068170 chr17:38103210 G/A cg17344932 chr17:38183730 MED24;SNORD124 -0.43 -6.83 -0.35 4.24e-11 Asthma and hay fever; CRC cis rs13256369 1.000 rs873064 chr8:8572380 G/A cg06636001 chr8:8085503 FLJ10661 0.46 5.82 0.31 1.39e-8 Obesity-related traits; CRC cis rs11098499 0.954 rs2306455 chr4:120421969 G/A cg24375607 chr4:120327624 NA 0.48 7.34 0.38 1.69e-12 Corneal astigmatism; CRC cis rs10174077 0.687 rs4664491 chr2:152479986 C/T cg19508488 chr2:152266495 RIF1 0.49 6.22 0.32 1.52e-9 Squamous cell lung carcinoma; CRC cis rs853679 0.550 rs1233704 chr6:28166923 A/G cg25164649 chr6:28176230 NA -0.79 -11.28 -0.53 3.57e-25 Depression; CRC cis rs13118159 0.550 rs4974612 chr4:1364543 A/G cg19318889 chr4:1322082 MAEA 0.69 10.14 0.49 3.2e-21 Longevity; CRC cis rs6504663 1.000 rs6504661 chr17:48580126 A/T cg11440486 chr17:48585216 MYCBPAP -0.43 -5.83 -0.31 1.33e-8 Visceral fat; CRC cis rs9902453 1.000 rs12600855 chr17:28279591 A/C cg26525008 chr17:28256777 EFCAB5;SSH2 0.58 8.77 0.44 9.82e-17 Coffee consumption (cups per day); CRC cis rs798554 1.000 rs798545 chr7:2762386 C/T cg13628971 chr7:2884303 GNA12 0.49 6.84 0.35 3.75e-11 Height; CRC cis rs7647973 0.961 rs11130186 chr3:49275828 A/G cg20833759 chr3:49053208 WDR6;DALRD3 0.53 8.13 0.41 8.68e-15 Menarche (age at onset); CRC trans rs1972460 0.506 rs62012050 chr15:82532274 T/G cg04831495 chr15:85060580 GOLGA6L5 -0.48 -6.82 -0.35 4.4e-11 Intelligence (multi-trait analysis); CRC cis rs660899 0.857 rs7520053 chr1:44226657 C/T cg10881128 chr1:44031826 PTPRF -0.21 -5.62 -0.3 4.11e-8 Hypertension risk in short sleep duration; CRC cis rs2153535 0.542 rs9505465 chr6:8510846 C/T cg07606381 chr6:8435919 SLC35B3 0.64 10.34 0.5 6.72e-22 Motion sickness; CRC cis rs4663866 1.000 rs4663300 chr2:239181491 T/C cg16914508 chr2:239161102 PER2 0.78 7.98 0.4 2.41e-14 Irritable bowel syndrome; CRC cis rs13098911 0.540 rs13097556 chr3:46061997 T/C cg12691230 chr3:46064611 XCR1 -0.53 -5.77 -0.3 1.83e-8 Celiac disease; CRC cis rs2882667 0.537 rs7704790 chr5:138410096 A/C cg09476006 chr5:138032270 NA 0.35 5.72 0.3 2.41e-8 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs8177253 0.665 rs12639304 chr3:133441594 A/T cg16262614 chr3:133464971 TF 0.35 6.22 0.32 1.49e-9 Iron status biomarkers; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg01240483 chr11:93861934 PANX1 0.42 6.2 0.32 1.73e-9 Response to antipsychotic treatment; CRC cis rs3736485 0.934 rs1077361 chr15:51880919 T/A cg08986416 chr15:51914746 DMXL2 -0.46 -6.56 -0.34 2.11e-10 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs897984 0.542 rs750952 chr16:31093954 C/T cg00531865 chr16:30841666 NA -0.4 -5.66 -0.3 3.22e-8 Dementia with Lewy bodies; CRC trans rs7618501 0.521 rs2883059 chr3:49902160 C/T cg21665057 chr3:196295764 WDR53;FBXO45 -0.53 -7.77 -0.39 1.03e-13 Intelligence (multi-trait analysis); CRC trans rs1814175 0.511 rs61905634 chr11:49819736 G/A cg15704280 chr7:45808275 SEPT13 -0.99 -19.52 -0.73 6.34e-57 Height; CRC cis rs4731207 0.698 rs10236403 chr7:124539542 C/T cg23710748 chr7:124431027 NA -0.36 -5.77 -0.3 1.79e-8 Cutaneous malignant melanoma; CRC cis rs992157 0.661 rs10171839 chr2:219051314 C/T cg00012203 chr2:219082015 ARPC2 0.59 9.68 0.47 1.17e-19 Colorectal cancer; CRC cis rs59918340 0.764 rs4961339 chr8:142231504 A/G cg17298326 chr8:142245477 NA -0.38 -5.79 -0.3 1.64e-8 Immature fraction of reticulocytes; CRC trans rs11825709 1.000 rs2460047 chr11:93678936 A/G cg08642771 chr1:198392758 NA -0.59 -6.51 -0.34 2.78e-10 Obesity-related traits; CRC cis rs6969780 0.915 rs11983200 chr7:27186596 A/G cg26364809 chr7:27145159 NA -0.74 -6.92 -0.36 2.31e-11 Diastolic blood pressure;Blood pressure traits (multi-trait analysis);Systolic blood pressure;Hypertension; CRC cis rs9905704 0.918 rs2611779 chr17:56791832 A/G cg12560992 chr17:57184187 TRIM37 0.53 7.31 0.37 1.99e-12 Testicular germ cell tumor; CRC cis rs3750082 0.852 rs2392152 chr7:32900549 A/G cg05721444 chr7:32995514 FKBP9 -0.49 -7.74 -0.39 1.24e-13 Glomerular filtration rate (creatinine); CRC cis rs8031584 0.958 rs34294266 chr15:31246840 A/G cg08109568 chr15:31115862 NA -0.54 -8.68 -0.43 1.87e-16 Huntington's disease progression; CRC cis rs8031584 0.723 rs11632229 chr15:31179534 A/G cg08109568 chr15:31115862 NA 0.56 9.18 0.45 4.87e-18 Huntington's disease progression; CRC cis rs832540 0.695 rs702686 chr5:56201350 A/G cg03609598 chr5:56110824 MAP3K1 -0.56 -7.56 -0.38 4.09e-13 Coronary artery disease; CRC cis rs4975709 0.610 rs1531994 chr5:1859297 T/C cg15595755 chr5:1867978 NA 0.36 5.83 0.31 1.29e-8 Cardiovascular disease risk factors; CRC cis rs916888 0.647 rs199524 chr17:44848438 G/T cg15921436 chr17:44337874 NA -0.51 -6.55 -0.34 2.27e-10 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs7584330 0.554 rs74449293 chr2:238426458 G/A cg14458575 chr2:238380390 NA 0.46 6.51 0.34 2.8e-10 Prostate cancer; CRC cis rs7827545 0.644 rs3739427 chr8:135524938 T/C cg17885191 chr8:135476712 NA -0.57 -7.5 -0.38 6e-13 Hypertension (SNP x SNP interaction); CRC cis rs282587 0.569 rs7326827 chr13:113408866 T/C cg04656015 chr13:113407548 ATP11A 0.62 7.97 0.4 2.63e-14 Glycated hemoglobin levels; CRC trans rs10021731 0.718 rs17678686 chr4:115410256 G/A cg25927708 chr2:119603813 EN1 -0.33 -6.01 -0.31 4.92e-9 Optic disc area; CRC trans rs1814175 0.676 rs1721999 chr11:49917372 A/G cg11707556 chr5:10655725 ANKRD33B -0.52 -9.95 -0.48 1.49e-20 Height; CRC cis rs4713118 0.662 rs149901 chr6:27965503 C/T cg12172441 chr6:28176163 NA 0.54 7.43 0.38 9.55e-13 Parkinson's disease; CRC cis rs9322193 0.923 rs1413654 chr6:150105092 G/A cg00933542 chr6:150070202 PCMT1 0.28 5.63 0.3 3.86e-8 Lung cancer; CRC cis rs2882667 0.861 rs11242445 chr5:138417054 G/T cg09476006 chr5:138032270 NA 0.4 6.65 0.34 1.19e-10 Age-related hearing impairment (SNP x SNP interaction); CRC trans rs2235573 0.653 rs3026670 chr22:38426774 T/C cg19894588 chr14:64061835 NA 0.43 6.14 0.32 2.32e-9 Glioblastoma;Glioma; CRC cis rs243505 0.762 rs734004 chr7:148505460 C/G cg09806900 chr7:148480153 CUL1 0.47 6.8 0.35 5.08e-11 Inflammatory bowel disease;Crohn's disease; CRC cis rs77956314 0.515 rs4238051 chr12:117366299 A/G cg25972092 chr12:117363249 FBXW8 0.55 6.33 0.33 8.06e-10 Subcortical brain region volumes;Hippocampal volume; CRC cis rs4728302 0.838 rs6974143 chr7:133603550 G/A cg03336402 chr7:133662267 EXOC4 -0.45 -6.52 -0.34 2.61e-10 Intelligence;Intelligence (multi-trait analysis); CRC cis rs939658 0.805 rs11635757 chr15:79432737 T/C cg17916960 chr15:79447300 NA -0.44 -7.23 -0.37 3.34e-12 Refractive error; CRC cis rs2836974 0.644 rs2836986 chr21:40702136 A/C cg11890956 chr21:40555474 PSMG1 -0.8 -12.39 -0.56 3.3600000000000003e-29 Cognitive function; CRC cis rs6665290 0.904 rs10495273 chr1:227183359 T/G cg10327440 chr1:227177885 CDC42BPA -1.04 -23.35 -0.79 8.31e-72 Myeloid white cell count; CRC cis rs9322193 0.962 rs6914319 chr6:150127440 G/A cg00933542 chr6:150070202 PCMT1 0.28 5.63 0.3 3.86e-8 Lung cancer; CRC cis rs9467773 1.000 rs9467791 chr6:26562486 A/G cg09904177 chr6:26538194 HMGN4 -0.84 -14.3 -0.62 2.08e-36 Intelligence (multi-trait analysis); CRC cis rs9649213 0.593 rs13232181 chr7:97935671 C/G cg21770322 chr7:97807741 LMTK2 0.48 7.92 0.4 3.8e-14 Prostate cancer (SNP x SNP interaction); CRC cis rs2404602 0.740 rs34924128 chr15:76965169 T/G cg03037974 chr15:76606532 NA 0.7 12.57 0.57 7.07e-30 Blood metabolite levels; CRC cis rs889312 0.500 rs865570 chr5:56161975 C/T cg18230493 chr5:56204884 C5orf35 -0.39 -5.77 -0.3 1.87e-8 Breast cancer;Breast cancer (early onset); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg10064079 chr20:44600917 ZNF335 0.45 6.16 0.32 2.08e-9 Response to antipsychotic treatment; CRC cis rs1670533 0.872 rs935969 chr4:1062588 A/G cg27284194 chr4:1044797 NA 0.51 6.37 0.33 6.52e-10 Recombination rate (females); CRC cis rs1577917 1.000 rs12205548 chr6:86759770 G/A cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.58 -7.07 -0.36 9.19e-12 Response to antipsychotic treatment; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg17315135 chr7:29234965 CHN2 0.38 6.02 0.31 4.62e-9 Liver disease severity in Alagille syndrome; CRC cis rs7224737 1.000 rs12603327 chr17:40290552 T/C cg00647820 chr17:40259828 DHX58 -0.46 -6.5 -0.34 3.04e-10 Fibrinogen levels; CRC cis rs12956009 0.583 rs11663609 chr18:44862757 C/T cg19077165 chr18:44547161 KATNAL2 -0.38 -5.6 -0.3 4.45e-8 Educational attainment (years of education); CRC cis rs6582630 0.512 rs11181007 chr12:38266700 C/T cg26384229 chr12:38710491 ALG10B -0.53 -7.66 -0.39 2.1e-13 Drug-induced liver injury (flucloxacillin); CRC cis rs7927771 0.524 rs10838769 chr11:47825333 A/G cg20307385 chr11:47447363 PSMC3 -0.46 -6.74 -0.35 7.09e-11 Subjective well-being; CRC trans rs9858542 0.953 rs35115732 chr3:49475155 T/C cg21665057 chr3:196295764 WDR53;FBXO45 -0.63 -8.63 -0.43 2.58e-16 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs3820068 0.603 rs67349836 chr1:15966176 T/C cg27534772 chr1:16042836 PLEKHM2 0.55 11.22 0.53 6.05e-25 Systolic blood pressure; CRC cis rs7605827 0.866 rs34815739 chr2:15533375 A/G cg19274914 chr2:15703543 NA 0.4 5.9 0.31 9.25e-9 Educational attainment (years of education); CRC cis rs73200209 0.665 rs17498599 chr12:116597253 C/T cg01776926 chr12:116560359 MED13L -0.63 -7.28 -0.37 2.52e-12 Total body bone mineral density; CRC cis rs877282 1.000 rs11253362 chr10:770979 G/T cg17470449 chr10:769945 NA 0.66 8.77 0.44 9.95e-17 Uric acid levels; CRC cis rs995000 0.931 rs12062275 chr1:62991905 T/C cg19896129 chr1:63156450 NA -0.45 -7.0 -0.36 1.48e-11 Triglyceride levels; CRC cis rs2839186 0.619 rs2187118 chr21:47611310 C/T cg26721908 chr21:47610096 LSS -0.44 -7.0 -0.36 1.46e-11 Testicular germ cell tumor; CRC cis rs4665809 1.000 rs4665305 chr2:26313524 C/T cg04944784 chr2:26401820 FAM59B -0.6 -7.84 -0.4 6.21e-14 Gut microbiome composition (summer); CRC trans rs7395662 0.963 rs10838967 chr11:48595007 C/T cg21153622 chr11:89784906 NA -0.45 -7.27 -0.37 2.58e-12 HDL cholesterol; CRC cis rs4588572 0.643 rs7716529 chr5:77738637 A/T cg11446398 chr5:77624930 NA 0.45 6.26 0.33 1.17e-9 Triglycerides; CRC trans rs10982213 0.830 rs2274163 chr9:117188714 C/T cg00441754 chr19:45394894 TOMM40 0.46 6.82 0.35 4.4e-11 Interleukin-6 levels; CRC cis rs6540556 1.000 rs6540556 chr1:209936631 G/A cg23920097 chr1:209922102 NA -0.53 -6.72 -0.35 7.86e-11 Red blood cell count; CRC cis rs875971 1.000 rs7789554 chr7:65946038 A/G cg12463550 chr7:65579703 CRCP 0.47 6.71 0.35 8.61e-11 Aortic root size; CRC cis rs4718428 1.000 rs1830070 chr7:66349671 T/C cg18252515 chr7:66147081 NA -0.49 -6.8 -0.35 4.79e-11 Corneal structure; CRC trans rs8002861 0.641 rs2325085 chr13:44410060 G/A cg12856521 chr11:46389249 DGKZ 0.43 6.88 0.35 3.1e-11 Leprosy; CRC cis rs7725052 0.609 rs60960096 chr5:40445914 A/G cg09067459 chr5:40385259 NA -0.39 -6.57 -0.34 1.96e-10 Pediatric autoimmune diseases; CRC cis rs11098499 0.754 rs11098502 chr4:120252063 T/A cg09307838 chr4:120376055 NA 0.61 9.59 0.47 2.22e-19 Corneal astigmatism; CRC cis rs7914558 1.000 rs12255047 chr10:104760752 G/A cg15744005 chr10:104629667 AS3MT -0.33 -6.95 -0.36 1.97e-11 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs7727544 0.716 rs10058655 chr5:131570896 A/T cg11843238 chr5:131593191 PDLIM4 0.35 6.51 0.34 2.8e-10 Blood metabolite levels; CRC cis rs853679 0.517 rs9468297 chr6:28118874 G/T cg02631126 chr6:28058918 ZSCAN12L1 0.29 5.91 0.31 8.38e-9 Depression; CRC cis rs4664308 0.658 rs12987602 chr2:160960788 G/T cg03641300 chr2:160917029 PLA2R1 -0.57 -9.17 -0.45 5.34e-18 Idiopathic membranous nephropathy; CRC cis rs6860806 0.507 rs272854 chr5:131688017 C/T cg09877947 chr5:131593287 PDLIM4 0.43 7.05 0.36 1.05e-11 Breast cancer; CRC trans rs916888 0.779 rs430685 chr17:44859148 T/C cg22433210 chr17:43662623 NA -0.82 -9.07 -0.45 1.11e-17 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC trans rs6598955 0.671 rs11247896 chr1:26600483 A/G cg07461501 chr17:79650226 HGS;ARL16 -0.52 -6.19 -0.32 1.77e-9 Obesity-related traits; CRC cis rs2836974 0.568 rs414850 chr21:40543337 A/C cg11644478 chr21:40555479 PSMG1 0.73 12.28 0.56 8.98e-29 Cognitive function; CRC cis rs11190604 0.767 rs11190534 chr10:102190930 G/A cg07080220 chr10:102295463 HIF1AN 0.5 6.35 0.33 7.2e-10 Palmitoleic acid (16:1n-7) levels; CRC cis rs10256972 0.567 rs2960835 chr7:1202963 A/G cg23978390 chr7:1156363 C7orf50 0.51 7.02 0.36 1.27e-11 Longevity;Endometriosis; CRC cis rs2721195 0.549 rs2958492 chr8:145919126 C/T cg26752003 chr8:145688521 CYHR1 -0.36 -5.84 -0.31 1.28e-8 Age at first birth; CRC cis rs2204008 0.774 rs9669565 chr12:38294428 C/A cg26384229 chr12:38710491 ALG10B 0.69 9.79 0.47 5.01e-20 Bladder cancer; CRC cis rs7312933 0.509 rs12831750 chr12:42466477 G/A cg11827402 chr12:42719852 PPHLN1;ZCRB1 0.58 6.15 0.32 2.26e-9 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg25725117 chr1:228871303 RHOU 0.42 5.97 0.31 6.29e-9 Anxiety disorder; CRC cis rs2230307 0.505 rs571579 chr1:100617372 G/A cg24955406 chr1:100503596 HIAT1 -0.5 -6.04 -0.32 4.28e-9 Carotid intima media thickness; CRC cis rs57221529 0.766 rs58015612 chr5:580665 A/T cg09021430 chr5:549028 NA -0.72 -7.9 -0.4 4.17e-14 Lung disease severity in cystic fibrosis; CRC cis rs4363385 0.510 rs6661063 chr1:153036048 C/A cg25856811 chr1:152973957 SPRR3 -0.21 -5.86 -0.31 1.14e-8 Inflammatory skin disease; CRC cis rs6951245 1.000 rs113146460 chr7:1105164 C/G cg21664854 chr7:1097933 C7orf50;GPR146 0.78 8.89 0.44 4.21e-17 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs12220238 1.000 rs10824085 chr10:75911984 T/C cg19889307 chr10:75911429 ADK;AP3M1 0.62 6.22 0.32 1.51e-9 Soluble interleukin-2 receptor subunit alpha; CRC cis rs2204008 0.643 rs1315347 chr12:38162494 C/T cg26384229 chr12:38710491 ALG10B -0.57 -8.42 -0.42 1.2e-15 Bladder cancer; CRC cis rs35306767 0.855 rs11253465 chr10:897208 A/C cg26597838 chr10:835615 NA 0.87 10.95 0.52 5.37e-24 Eosinophil percentage of granulocytes; CRC cis rs1862618 0.671 rs906631 chr5:56245803 C/G cg24531977 chr5:56204891 C5orf35 0.66 10.27 0.49 1.24e-21 Initial pursuit acceleration; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg13627451 chr15:52043674 TMOD2;LYSMD2 0.38 6.19 0.32 1.75e-9 Liver disease severity in Alagille syndrome; CRC cis rs763121 0.819 rs5757169 chr22:39003495 G/A cg06022373 chr22:39101656 GTPBP1 0.8 13.46 0.6 3.35e-33 Menopause (age at onset); CRC cis rs1451375 0.698 rs56233242 chr7:50634053 C/A cg14593290 chr7:50529359 DDC 0.52 7.24 0.37 3.11e-12 Malaria; CRC cis rs1799949 0.965 rs12947782 chr17:41279882 A/G cg05368731 chr17:41323189 NBR1 0.69 10.48 0.5 2.22e-22 Menopause (age at onset); CRC cis rs780096 0.526 rs4803 chr2:27667297 A/G cg12648201 chr2:27665141 KRTCAP3 -0.32 -6.36 -0.33 6.91e-10 Total body bone mineral density; CRC cis rs863345 0.967 rs7512117 chr1:158532064 C/T cg12129480 chr1:158549410 OR10X1 -0.26 -5.66 -0.3 3.32e-8 Pneumococcal bacteremia; CRC cis rs3733585 0.673 rs6449156 chr4:9956712 G/C cg00071950 chr4:10020882 SLC2A9 -0.54 -9.65 -0.47 1.5e-19 Cleft plate (environmental tobacco smoke interaction); CRC cis rs2153535 0.580 rs4639392 chr6:8446547 A/G cg21535247 chr6:8435926 SLC35B3 0.5 7.5 0.38 6.06e-13 Motion sickness; CRC cis rs6502050 0.835 rs8067875 chr17:80092778 C/T cg11859384 chr17:80120422 CCDC57 -0.37 -5.84 -0.31 1.22e-8 Life satisfaction; CRC cis rs929596 0.755 rs4148324 chr2:234672722 T/G cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.7 -10.94 -0.52 5.67e-24 Total bilirubin levels in HIV-1 infection; CRC cis rs9549367 0.826 rs9549713 chr13:113905308 G/T cg18105134 chr13:113819100 PROZ -0.74 -10.54 -0.5 1.38e-22 Platelet distribution width; CRC cis rs868036 0.957 rs9920662 chr15:68104297 G/A cg05925327 chr15:68127851 NA -0.3 -5.88 -0.31 9.91e-9 Restless legs syndrome; CRC cis rs10504073 0.565 rs12056536 chr8:49890132 C/T cg00325661 chr8:49890786 NA -0.61 -11.15 -0.52 1.02e-24 Blood metabolite ratios; CRC trans rs12599106 0.560 rs34151874 chr16:34989694 G/A cg01171360 chr6:293285 DUSP22 -0.56 -8.05 -0.41 1.55e-14 Menopause (age at onset); CRC cis rs2985684 1.000 rs2224949 chr14:50096560 A/G cg04989706 chr14:50066350 PPIL5 0.47 6.56 0.34 2.11e-10 Carotid intima media thickness; CRC cis rs780096 0.526 rs11127013 chr2:27692973 A/G cg17158414 chr2:27665306 KRTCAP3 -0.29 -6.18 -0.32 1.9e-9 Total body bone mineral density; CRC cis rs7618915 0.501 rs11130308 chr3:52639257 G/C cg15147215 chr3:52552868 STAB1 -0.63 -10.85 -0.51 1.15e-23 Bipolar disorder; CRC cis rs2730245 0.569 rs1188955 chr7:158690866 A/G cg24397884 chr7:158709396 WDR60 0.7 9.74 0.47 7.38e-20 Height; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg26611836 chr5:126112609 LMNB1 0.45 6.34 0.33 7.78e-10 Response to antipsychotic treatment; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg00171161 chr4:88343636 NUDT9 0.46 6.48 0.34 3.38e-10 Response to antipsychotic treatment; CRC cis rs6502050 0.734 rs7217625 chr17:80157766 T/C cg22110888 chr17:80059540 CCDC57 0.38 6.07 0.32 3.61e-9 Life satisfaction; CRC trans rs11098499 0.954 rs7654587 chr4:120388406 C/T cg25214090 chr10:38739885 LOC399744 0.66 10.55 0.5 1.36e-22 Corneal astigmatism; CRC cis rs2404602 0.692 rs4641709 chr15:77047736 C/T cg22467129 chr15:76604101 ETFA 0.38 6.12 0.32 2.69e-9 Blood metabolite levels; CRC cis rs1799949 1.000 rs11651341 chr17:41428061 T/C cg25072359 chr17:41440525 NA 0.42 6.33 0.33 7.89e-10 Menopause (age at onset); CRC cis rs728616 0.867 rs726289 chr10:81706951 C/T cg11900509 chr10:81946545 ANXA11 -0.71 -7.14 -0.37 6.18e-12 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs1950626 0.833 rs72700524 chr14:101417309 G/A cg02351406 chr14:101447389 SNORD114-20;SNORD114-21 0.95 16.09 0.66 2.16e-43 Pelvic organ prolapse (moderate/severe); CRC cis rs812925 0.519 rs10199672 chr2:61627634 T/G cg10580144 chr2:61372316 C2orf74 -0.33 -7.2 -0.37 4.21e-12 Immature fraction of reticulocytes; CRC cis rs2153535 0.580 rs9406170 chr6:8514153 T/C cg07606381 chr6:8435919 SLC35B3 0.65 10.53 0.5 1.58e-22 Motion sickness; CRC cis rs8072100 0.967 rs4794001 chr17:45720849 T/C cg08085267 chr17:45401833 C17orf57 -0.6 -9.67 -0.47 1.25e-19 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs952623 0.501 rs1000869 chr7:39082227 A/G cg18850127 chr7:39170497 POU6F2 0.45 5.81 0.31 1.47e-8 Intelligence (multi-trait analysis); CRC cis rs9783347 1.000 rs4150575 chr11:18356466 C/T cg15585147 chr11:18324498 HPS5 0.43 6.02 0.31 4.67e-9 Pancreatic cancer; CRC cis rs17376456 0.877 rs10055340 chr5:93317644 T/C cg21475434 chr5:93447410 FAM172A 0.79 8.19 0.41 5.81e-15 Diabetic retinopathy; CRC cis rs7605827 0.897 rs763355 chr2:15518838 A/G cg19274914 chr2:15703543 NA 0.38 5.63 0.3 3.81e-8 Educational attainment (years of education); CRC cis rs7781266 0.895 rs7779631 chr7:133303907 G/C cg03336402 chr7:133662267 EXOC4 0.49 6.02 0.31 4.7e-9 Educational attainment (college completion); CRC cis rs4819052 0.918 rs34886433 chr21:46680538 G/C cg19498844 chr21:46707878 POFUT2;LOC642852 0.82 10.28 0.49 1.13e-21 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg14390580 chr17:35873008 DUSP14 -0.41 -6.67 -0.35 1.11e-10 Liver disease severity in Alagille syndrome; CRC cis rs9611565 0.512 rs8141103 chr22:42136930 T/C cg03806693 chr22:41940476 POLR3H 1.08 13.41 0.59 5.35e-33 Vitiligo; CRC trans rs3780486 1.000 rs12342831 chr9:33124872 A/G cg04842962 chr6:43655489 MRPS18A 1.0 15.69 0.65 8.44e-42 IgG glycosylation; CRC cis rs2386661 0.712 rs11259544 chr10:5646708 T/C cg02449762 chr10:5661741 NA -0.32 -5.71 -0.3 2.57e-8 Breast cancer; CRC trans rs16846053 0.786 rs62187647 chr2:162446018 C/T cg18122310 chr12:50236657 BCDIN3D -0.74 -6.19 -0.32 1.81e-9 Blood osmolality (transformed sodium); CRC cis rs477895 0.838 rs11607007 chr11:64007976 C/T cg23719950 chr11:63933701 MACROD1 -0.57 -6.84 -0.35 3.8e-11 Mean platelet volume; CRC cis rs6460942 1.000 rs79964328 chr7:12319392 A/C cg06484146 chr7:12443880 VWDE -0.76 -7.53 -0.38 4.85e-13 Coronary artery disease; CRC cis rs7044106 0.791 rs735110 chr9:123488940 T/A cg09586646 chr9:123605570 PSMD5;LOC253039 0.69 10.09 0.49 5.1e-21 Hip circumference adjusted for BMI; CRC trans rs4650994 1.000 rs12138561 chr1:178518784 G/T cg05059571 chr16:84539110 KIAA1609 -0.48 -7.33 -0.37 1.84e-12 HDL cholesterol levels;HDL cholesterol; CRC cis rs13082711 0.516 rs1388786 chr3:27372222 G/A cg02860705 chr3:27208620 NA -0.52 -7.47 -0.38 7.07e-13 Systolic blood pressure;Diastolic blood pressure;Blood pressure; CRC trans rs7267979 0.739 rs6138555 chr20:25242910 G/A cg17903999 chr18:56338584 MALT1 -0.41 -6.52 -0.34 2.58e-10 Liver enzyme levels (alkaline phosphatase); CRC cis rs748404 0.631 rs6493083 chr15:43637985 A/G cg02155558 chr15:43621948 ADAL;LCMT2 0.54 7.81 0.4 7.93e-14 Lung cancer; CRC trans rs2303319 0.504 rs62187611 chr2:162431946 A/G cg09481857 chr22:21368659 P2RX6;MGC16703 -0.66 -6.14 -0.32 2.36e-9 Cognitive function; CRC cis rs1448094 0.511 rs2405623 chr12:86153466 G/A cg02569458 chr12:86230093 RASSF9 -0.47 -7.98 -0.4 2.49e-14 Major depressive disorder; CRC cis rs904251 0.772 rs2776906 chr6:37431757 A/G cg01843034 chr6:37503916 NA -0.36 -5.96 -0.31 6.34e-9 Cognitive performance; CRC cis rs13108904 0.935 rs13148614 chr4:1248357 G/C cg15763984 chr4:1342303 KIAA1530 0.34 5.69 0.3 2.83e-8 Obesity-related traits; CRC cis rs763121 0.853 rs8140617 chr22:38970439 A/G cg06022373 chr22:39101656 GTPBP1 -0.77 -11.46 -0.53 8.05e-26 Menopause (age at onset); CRC cis rs4889855 0.530 rs72856551 chr17:78552267 G/T cg16591659 chr17:78472290 NA 0.4 5.73 0.3 2.32e-8 Fractional excretion of uric acid; CRC cis rs10504073 0.647 rs10808744 chr8:49988984 A/G cg00325661 chr8:49890786 NA 0.52 9.2 0.45 4.37e-18 Blood metabolite ratios; CRC cis rs6831352 0.703 rs4235435 chr4:100039578 C/T cg13256891 chr4:100009986 ADH5 0.56 7.89 0.4 4.44e-14 Alcohol dependence; CRC cis rs561341 0.883 rs4795661 chr17:30201774 T/A cg23018236 chr17:30244563 NA 0.52 6.64 0.34 1.3100000000000001e-10 Hip circumference adjusted for BMI; CRC cis rs4563143 0.514 rs55727361 chr19:29300415 A/T cg14983838 chr19:29218262 NA 0.52 7.0 0.36 1.45e-11 Methadone dose in opioid dependence; CRC cis rs13118159 0.872 rs1882105 chr4:1345956 T/C cg15763984 chr4:1342303 KIAA1530 0.51 8.58 0.43 3.72e-16 Longevity; CRC cis rs7224314 1.000 rs8075952 chr17:65381358 C/T cg01507342 chr17:65387096 PITPNC1 -0.57 -8.03 -0.4 1.74e-14 Diisocyanate-induced asthma; CRC cis rs11122272 0.735 rs2790889 chr1:231520240 C/A cg06096015 chr1:231504339 EGLN1 0.4 5.94 0.31 7.17e-9 Hemoglobin concentration; CRC cis rs2692947 0.800 rs4332959 chr2:96549121 C/T cg23100626 chr2:96804247 ASTL 0.26 7.07 0.36 9.21e-12 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; CRC cis rs6860806 0.507 rs270606 chr5:131650867 A/G cg09877947 chr5:131593287 PDLIM4 0.46 7.49 0.38 6.3e-13 Breast cancer; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg15481787 chr19:18303865 MPV17L2 0.48 6.83 0.35 4.24e-11 Response to antipsychotic treatment; CRC cis rs4332037 0.624 rs73046339 chr7:1889300 G/A cg23422044 chr7:1970798 MAD1L1 -0.5 -6.57 -0.34 2.02e-10 Bipolar disorder; CRC cis rs617791 0.530 rs55947178 chr11:65754230 G/A cg27068330 chr11:65405492 SIPA1 -0.46 -6.31 -0.33 9.09e-10 Breast cancer; CRC cis rs9534288 0.797 rs992631 chr13:46591989 A/G cg15192986 chr13:46630673 CPB2 0.67 9.78 0.47 5.45e-20 Blood protein levels; CRC cis rs2836974 0.965 rs2836965 chr21:40633631 C/G cg11890956 chr21:40555474 PSMG1 -1.07 -18.09 -0.71 2.95e-51 Cognitive function; CRC trans rs7395662 1.000 rs11039859 chr11:48611988 G/T cg21153622 chr11:89784906 NA -0.48 -7.68 -0.39 1.78e-13 HDL cholesterol; CRC cis rs4664293 0.625 rs35481084 chr2:160634240 G/A cg08347373 chr2:160653686 CD302 0.43 7.42 0.38 1.03e-12 Monocyte percentage of white cells; CRC trans rs561341 1.000 rs548957 chr17:30302411 G/A cg20587970 chr11:113659929 NA -1.43 -20.51 -0.75 8.67e-61 Hip circumference adjusted for BMI; CRC cis rs1552244 1.000 rs61077902 chr3:10126153 T/G cg00166722 chr3:10149974 C3orf24 0.69 9.45 0.46 6.61e-19 Alzheimer's disease; CRC cis rs8014204 0.901 rs6574200 chr14:75364451 C/T cg03030879 chr14:75389066 RPS6KL1 0.54 8.72 0.43 1.39e-16 Caffeine consumption; CRC trans rs57221529 0.713 rs12521091 chr5:590710 G/T cg11887960 chr12:57824829 NA 0.62 6.77 0.35 5.9e-11 Lung disease severity in cystic fibrosis; CRC cis rs17253792 0.822 rs10083493 chr14:56045411 C/T cg01858014 chr14:56050164 KTN1 -0.87 -7.54 -0.38 4.73e-13 Putamen volume; CRC cis rs1448094 0.511 rs11117042 chr12:86207547 G/T cg06740227 chr12:86229804 RASSF9 0.36 5.76 0.3 1.95e-8 Major depressive disorder; CRC cis rs6502050 0.805 rs7406682 chr17:80084368 C/T cg25804541 chr17:80189381 SLC16A3 0.31 5.9 0.31 8.94e-9 Life satisfaction; CRC cis rs10504229 0.906 rs116341227 chr8:58190532 G/C cg01721255 chr8:58191610 C8orf71 0.49 6.14 0.32 2.4e-9 Developmental language disorder (linguistic errors); CRC cis rs10743315 0.778 rs7399032 chr12:19371546 T/C cg02471346 chr12:19282374 PLEKHA5 -0.63 -8.0 -0.4 2.18e-14 Gut microbiota (bacterial taxa); CRC cis rs1669338 0.588 rs62228634 chr3:3184985 A/G cg16797762 chr3:3221439 CRBN -0.6 -6.1 -0.32 2.9e-9 White matter integrity; CRC cis rs9467711 0.538 rs9467632 chr6:25889706 A/G cg16898833 chr6:26189333 HIST1H4D 0.82 6.88 0.35 2.97e-11 Autism spectrum disorder or schizophrenia; CRC trans rs9329221 0.655 rs656319 chr8:9814411 A/G cg06636001 chr8:8085503 FLJ10661 -0.55 -8.45 -0.42 9.75e-16 Neuroticism; CRC cis rs4689388 0.926 rs5018648 chr4:6292818 C/G cg00701064 chr4:6280414 WFS1 -0.74 -12.96 -0.58 2.46e-31 Type 2 diabetes and other traits;Type 2 diabetes; CRC cis rs977987 0.836 rs17685540 chr16:75323840 T/C cg03315344 chr16:75512273 CHST6 0.54 8.95 0.44 2.67e-17 Dupuytren's disease; CRC cis rs4664293 0.867 rs1427329 chr2:160604812 C/T cg08347373 chr2:160653686 CD302 -0.43 -6.85 -0.35 3.64e-11 Monocyte percentage of white cells; CRC cis rs11864453 0.713 rs12708927 chr16:72126165 C/T cg23815491 chr16:72088622 HP 0.5 7.6 0.39 3.09e-13 Fibrinogen levels; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg19056506 chr17:79633562 CCDC137;C17orf90 0.43 6.07 0.32 3.61e-9 Anxiety disorder; CRC cis rs929354 0.742 rs2006844 chr7:157002851 G/A cg16102536 chr7:156981717 UBE3C 0.4 6.77 0.35 5.75e-11 Body mass index; CRC cis rs2197308 0.610 rs10880837 chr12:37864924 C/T cg26384229 chr12:38710491 ALG10B 0.67 8.86 0.44 5.2e-17 Morning vs. evening chronotype; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg21742872 chr21:43373869 C2CD2 0.44 6.2 0.32 1.64e-9 Anxiety disorder; CRC cis rs597539 0.518 rs35093305 chr11:68730729 A/G cg04772025 chr11:68637568 NA 0.44 6.66 0.34 1.16e-10 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs4713118 0.597 rs172166 chr6:28020820 C/G cg15845792 chr6:28175446 NA 0.9 13.11 0.59 6.83e-32 Parkinson's disease; CRC cis rs17376456 0.741 rs10036829 chr5:93309897 G/C cg21475434 chr5:93447410 FAM172A 0.77 7.8 0.4 8.13e-14 Diabetic retinopathy; CRC cis rs11792861 0.926 rs72607171 chr9:111837776 T/C cg05043794 chr9:111880884 C9orf5 -0.36 -6.57 -0.34 1.95e-10 Menarche (age at onset); CRC cis rs76419734 0.558 rs10019217 chr4:106588509 C/T cg05309399 chr4:106552544 FLJ20184 -0.45 -5.61 -0.3 4.31e-8 Post bronchodilator FEV1; CRC cis rs9768139 0.708 rs10262596 chr7:158114495 G/A cg25566285 chr7:158114605 PTPRN2 0.52 8.58 0.43 3.77e-16 Calcium levels; CRC trans rs2795502 1.000 rs2142991 chr10:43341105 C/T cg06791473 chr12:49259579 RND1 0.61 5.99 0.31 5.45e-9 Blood protein levels; CRC cis rs2645694 0.533 rs2645680 chr4:77820956 T/C cg10057126 chr4:77819792 ANKRD56 0.34 5.7 0.3 2.66e-8 Emphysema distribution in smoking; CRC trans rs1814175 0.935 rs28586931 chr11:49693872 G/A cg15704280 chr7:45808275 SEPT13 -0.98 -18.48 -0.71 8.6e-53 Height; CRC trans rs7618501 1.000 rs3749241 chr3:49744392 A/G cg21659725 chr3:3221576 CRBN -0.9 -17.41 -0.69 1.45e-48 Intelligence (multi-trait analysis); CRC cis rs921968 0.565 rs7595901 chr2:219606931 A/G cg02176678 chr2:219576539 TTLL4 -0.43 -6.77 -0.35 5.94e-11 Mean corpuscular hemoglobin concentration; CRC cis rs897984 0.645 rs58726213 chr16:31044683 A/G cg00531865 chr16:30841666 NA -0.45 -6.38 -0.33 6.05e-10 Dementia with Lewy bodies; CRC cis rs826838 0.868 rs12322306 chr12:39130021 A/G cg26384229 chr12:38710491 ALG10B -0.64 -9.67 -0.47 1.21e-19 Heart rate; CRC cis rs1215050 0.904 rs1727285 chr4:98978821 G/A cg05340658 chr4:99064831 C4orf37 -0.44 -6.15 -0.32 2.26e-9 Waist-to-hip ratio adjusted for body mass index; CRC cis rs7786808 0.653 rs7810861 chr7:158212633 G/A cg17401720 chr7:158221031 PTPRN2 0.41 6.54 0.34 2.3e-10 Obesity-related traits; CRC cis rs6860806 0.631 rs7736284 chr5:131588151 T/C cg09877947 chr5:131593287 PDLIM4 0.46 8.42 0.42 1.2e-15 Breast cancer; CRC cis rs7072216 0.763 rs3750601 chr10:100174561 C/A cg26618903 chr10:100175079 PYROXD2 -0.55 -8.99 -0.44 2.03e-17 Metabolite levels; CRC cis rs10106298 0.846 rs2099408 chr8:103680416 A/C cg10187029 chr8:103597600 NA 0.42 5.86 0.31 1.12e-8 Schizophrenia; CRC cis rs2243480 1.000 rs7778911 chr7:65694506 T/C cg25985355 chr7:65971099 NA 0.51 5.75 0.3 2.08e-8 Diabetic kidney disease; CRC cis rs977987 0.806 rs4888391 chr16:75400746 C/T cg03315344 chr16:75512273 CHST6 0.54 9.07 0.45 1.1e-17 Dupuytren's disease; CRC cis rs1552244 0.882 rs13064570 chr3:9997545 G/C cg13047869 chr3:10149882 C3orf24 0.49 6.66 0.34 1.18e-10 Alzheimer's disease; CRC cis rs9549367 0.789 rs9549361 chr13:113898329 C/T cg00898013 chr13:113819073 PROZ 0.44 6.15 0.32 2.19e-9 Platelet distribution width; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg05484920 chr19:49588520 SNRNP70 0.44 6.14 0.32 2.34e-9 Response to antipsychotic treatment; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg09901735 chr16:19729769 C16orf88;IQCK 0.49 6.86 0.35 3.46e-11 Response to antipsychotic treatment; CRC trans rs9858542 0.953 rs6766581 chr3:49539401 T/C cg21659725 chr3:3221576 CRBN -0.66 -8.98 -0.44 2.18e-17 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs2073300 0.609 rs6137941 chr20:23400848 G/A cg12062639 chr20:23401060 NAPB 0.84 7.59 0.39 3.31e-13 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs9291683 0.546 rs13110307 chr4:10044364 T/C cg11266682 chr4:10021025 SLC2A9 0.52 10.62 0.51 7.35e-23 Bone mineral density; CRC cis rs7258465 1.000 rs8105994 chr19:18593553 A/G cg06462663 chr19:18546047 ISYNA1 0.42 6.04 0.32 4.1e-9 Breast cancer; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg09092174 chr22:39190118 DNAL4 0.47 6.59 0.34 1.77e-10 Response to antipsychotic treatment; CRC cis rs7666738 0.830 rs28444709 chr4:99028496 A/T cg17366294 chr4:99064904 C4orf37 0.44 7.48 0.38 6.96e-13 Colonoscopy-negative controls vs population controls; CRC cis rs3736594 1.000 rs3792252 chr2:27995931 A/G cg27432699 chr2:27873401 GPN1 0.55 7.65 0.39 2.31e-13 Fasting blood glucose;Fasting blood glucose (BMI interaction); CRC cis rs929354 0.772 rs6459738 chr7:156998532 T/G cg05182265 chr7:156933206 UBE3C -0.76 -14.52 -0.62 3.01e-37 Body mass index; CRC cis rs7589728 0.563 rs75606549 chr2:88466069 T/C cg07952391 chr2:88470173 THNSL2 0.66 6.77 0.35 5.88e-11 Plasma clusterin levels; CRC cis rs7605827 0.930 rs6722963 chr2:15527105 C/T cg19274914 chr2:15703543 NA 0.39 5.9 0.31 8.92e-9 Educational attainment (years of education); CRC cis rs2760061 0.598 rs632832 chr1:228121838 G/T cg18477163 chr1:228402036 OBSCN -0.35 -5.74 -0.3 2.2e-8 Diastolic blood pressure; CRC cis rs6840360 0.967 rs17027798 chr4:152597540 A/G cg09659197 chr4:152720779 NA 0.52 11.24 0.53 4.87e-25 Intelligence (multi-trait analysis); CRC cis rs8014204 0.657 rs2884668 chr14:75281576 T/A cg03030879 chr14:75389066 RPS6KL1 -0.4 -6.31 -0.33 9.21e-10 Caffeine consumption; CRC trans rs7829975 0.688 rs6601703 chr8:8380224 A/G cg16141378 chr3:129829833 LOC729375 -0.49 -7.55 -0.38 4.35e-13 Mood instability; CRC cis rs7762018 0.891 rs7764839 chr6:170146351 C/A cg24289452 chr6:170231220 NA -0.57 -6.39 -0.33 5.75e-10 Thiazide-induced adverse metabolic effects in hypertensive patients; CRC cis rs1401999 0.546 rs56889301 chr3:183675315 T/C cg01324343 chr3:183735012 ABCC5 0.67 11.42 0.53 1.15e-25 Anterior chamber depth; CRC cis rs2153535 0.580 rs7743418 chr6:8438128 A/C cg21535247 chr6:8435926 SLC35B3 0.47 7.14 0.37 5.87e-12 Motion sickness; CRC cis rs6570726 0.967 rs441364 chr6:145853662 G/C cg23711669 chr6:146136114 FBXO30 0.73 12.68 0.57 2.78e-30 Lobe attachment (rater-scored or self-reported); CRC cis rs9768139 0.935 rs10949715 chr7:158117246 G/T cg25566285 chr7:158114605 PTPRN2 0.61 10.44 0.5 3.17e-22 Calcium levels; CRC cis rs514406 0.661 rs562641 chr1:53374666 C/T cg25767906 chr1:53392781 SCP2 -0.5 -7.68 -0.39 1.89e-13 Monocyte count; CRC cis rs6681460 0.966 rs10789215 chr1:67151185 C/T cg02459107 chr1:67143332 SGIP1 -0.4 -7.08 -0.36 8.94e-12 Presence of antiphospholipid antibodies; CRC cis rs853679 0.824 rs1321505 chr6:28052823 A/C cg03623178 chr6:28175578 NA 0.84 6.98 0.36 1.68e-11 Depression; CRC cis rs8077889 0.956 rs55768269 chr17:41888997 C/T cg25876840 chr17:41920477 NA 0.55 7.52 0.38 5.14e-13 Triglycerides; CRC cis rs28386778 1.000 rs28386778 chr17:61964815 T/C cg06873352 chr17:61820015 STRADA 0.75 13.14 0.59 5.55e-32 Prudent dietary pattern; CRC cis rs6714710 0.603 rs11692010 chr2:98397301 C/T cg26665480 chr2:98280029 ACTR1B 0.52 7.23 0.37 3.45e-12 Posterior cortical atrophy and Alzheimer's disease; CRC cis rs17384381 1.000 rs12123745 chr1:85884772 T/C cg16011679 chr1:85725395 C1orf52 0.65 6.68 0.35 1.05e-10 Lobe attachment (rater-scored or self-reported); CRC cis rs6840360 0.642 rs7676059 chr4:152393267 T/C cg09659197 chr4:152720779 NA 0.33 6.56 0.34 2.13e-10 Intelligence (multi-trait analysis); CRC cis rs3733585 0.699 rs4339211 chr4:9947658 C/T cg00071950 chr4:10020882 SLC2A9 -0.56 -9.88 -0.48 2.46e-20 Cleft plate (environmental tobacco smoke interaction); CRC cis rs2839186 0.771 rs13049175 chr21:47641326 G/A cg13012494 chr21:47604986 C21orf56 -0.47 -7.4 -0.38 1.11e-12 Testicular germ cell tumor; CRC cis rs524023 1.000 rs11602903 chr11:64358241 A/T cg14139581 chr11:64358342 SLC22A12 -0.39 -6.19 -0.32 1.81e-9 Urate levels in obese individuals; CRC cis rs9326248 1.000 rs10790175 chr11:117034729 A/G cg10130564 chr11:117069849 TAGLN 0.35 6.7 0.35 8.95e-11 Blood protein levels; CRC cis rs75422866 0.558 rs73104190 chr12:48109823 G/A cg14736327 chr12:48174669 SLC48A1 -0.73 -5.76 -0.3 1.94e-8 Pneumonia; CRC trans rs1997103 1.000 rs2331064 chr7:55408610 C/G cg20935933 chr6:143382018 AIG1 0.51 6.65 0.34 1.25e-10 QRS interval (sulfonylurea treatment interaction); CRC cis rs3820928 1.000 rs6752707 chr2:227766822 C/G cg11843606 chr2:227700838 RHBDD1 -0.4 -5.74 -0.3 2.11e-8 Pulmonary function; CRC cis rs7107770 0.629 rs4936993 chr11:125071752 G/A cg27629782 chr11:125073726 PKNOX2 0.48 6.84 0.35 3.93e-11 Photic sneeze reflex; CRC cis rs2239547 0.657 rs2276817 chr3:52860936 C/T cg15147215 chr3:52552868 STAB1 -0.43 -6.09 -0.32 3.12e-9 Schizophrenia; CRC cis rs11711311 1.000 rs9828099 chr3:113518402 T/C cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.52 -7.08 -0.36 8.63e-12 IgG glycosylation; CRC cis rs1552244 0.882 rs13099507 chr3:10031603 G/A cg10729496 chr3:10149963 C3orf24 0.52 6.41 0.33 5.07e-10 Alzheimer's disease; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg00969988 chr3:142297747 ATR 0.39 6.52 0.34 2.61e-10 Liver disease severity in Alagille syndrome; CRC trans rs1814175 0.669 rs12416837 chr11:49669761 G/T cg03929089 chr4:120376271 NA -0.71 -11.46 -0.53 8.48e-26 Height; CRC cis rs7552404 1.000 rs12127402 chr1:76205643 C/A cg22875332 chr1:76189707 ACADM 0.69 9.27 0.46 2.56e-18 Blood metabolite levels;Acylcarnitine levels; CRC cis rs2645694 0.626 rs2645704 chr4:77830805 T/C cg10057126 chr4:77819792 ANKRD56 0.34 5.71 0.3 2.58e-8 Emphysema distribution in smoking; CRC cis rs2384207 0.818 rs34326408 chr12:113647337 T/C cg22376712 chr12:113623594 C12orf52;DDX54 0.48 6.03 0.32 4.44e-9 Response to fenofibrate (adiponectin levels); CRC cis rs73206853 0.841 rs7971568 chr12:110780612 G/A cg12870014 chr12:110450643 ANKRD13A 0.8 7.71 0.39 1.55e-13 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC cis rs1552244 0.572 rs3894321 chr3:10168892 A/C cg10729496 chr3:10149963 C3orf24 0.49 5.77 0.3 1.84e-8 Alzheimer's disease; CRC cis rs6952808 0.792 rs35582663 chr7:1948756 G/A cg21782813 chr7:2030301 MAD1L1 0.45 7.5 0.38 6.12e-13 Bipolar disorder and schizophrenia; CRC cis rs637571 0.522 rs1151512 chr11:65757533 G/A cg17985854 chr11:65770987 BANF1;EIF1AD 0.52 8.93 0.44 3.11e-17 Eosinophil percentage of white cells; CRC cis rs365302 0.868 rs381639 chr6:159653635 C/G cg14500486 chr6:159655392 FNDC1 -0.45 -6.81 -0.35 4.7e-11 Coronary heart disease; CRC cis rs7412746 0.658 rs4970982 chr1:150865084 G/C cg10589385 chr1:150898437 SETDB1 0.33 7.02 0.36 1.26e-11 Melanoma; CRC cis rs6502050 0.805 rs7503095 chr17:80107354 G/A cg02741985 chr17:80059408 CCDC57 0.43 7.15 0.37 5.66e-12 Life satisfaction; CRC cis rs2050392 1.000 rs2050392 chr10:30691503 G/A cg18806716 chr10:30721971 MAP3K8 -0.46 -6.95 -0.36 1.92e-11 Inflammatory bowel disease; CRC cis rs4713118 0.527 rs4713151 chr6:28136356 G/A cg12273811 chr6:28175739 NA 0.73 9.16 0.45 5.8e-18 Parkinson's disease; CRC trans rs17685 0.535 rs41299460 chr7:75600951 G/A cg19862616 chr7:65841803 NCRNA00174 0.44 6.13 0.32 2.46e-9 Coffee consumption;Coffee consumption (cups per day); CRC cis rs9457247 0.765 rs3752520 chr6:167436159 T/C cg07741184 chr6:167504864 NA 0.4 6.78 0.35 5.58e-11 Crohn's disease; CRC cis rs1008375 0.966 rs3775924 chr4:17585984 T/C cg02297831 chr4:17616191 MED28 0.45 5.82 0.31 1.41e-8 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs1451375 0.794 rs11238134 chr7:50542927 A/C cg14593290 chr7:50529359 DDC -0.52 -7.69 -0.39 1.76e-13 Malaria; CRC cis rs1801251 1.000 rs1947105 chr2:233721455 A/G cg25237894 chr2:233734115 C2orf82 0.52 8.41 0.42 1.24e-15 Coronary artery disease; CRC cis rs6831352 0.819 rs1154401 chr4:100009738 G/C cg12011299 chr4:100065546 ADH4 0.49 10.23 0.49 1.62e-21 Alcohol dependence; CRC cis rs3760982 0.845 rs62116962 chr19:44287234 A/G cg11993925 chr19:44307056 LYPD5 -0.47 -7.78 -0.39 9.23e-14 Breast cancer (estrogen-receptor negative);Breast cancer; CRC cis rs875971 1.000 rs6460292 chr7:65810075 G/A cg12463550 chr7:65579703 CRCP -0.49 -7.07 -0.36 9.23e-12 Aortic root size; CRC cis rs4700695 0.841 rs36301 chr5:65348940 A/G cg21114390 chr5:65439923 SFRS12 0.59 7.19 0.37 4.36e-12 Facial morphology (factor 19); CRC cis rs7618915 0.547 rs62253733 chr3:52653414 A/G cg18404041 chr3:52824283 ITIH1 -0.44 -9.05 -0.45 1.26e-17 Bipolar disorder; CRC cis rs17092148 0.652 rs61341205 chr20:33072578 A/G cg08999081 chr20:33150536 PIGU -0.45 -5.67 -0.3 3.18e-8 Neuroticism; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg01069104 chr3:18467441 SATB1 0.38 6.17 0.32 2.05e-9 Liver disease severity in Alagille syndrome; CRC trans rs561341 1.000 rs55959993 chr17:30254771 C/G cg27661571 chr11:113659931 NA -0.96 -11.11 -0.52 1.42e-24 Hip circumference adjusted for BMI; CRC cis rs12325245 0.536 rs17821549 chr16:58554780 C/T cg01472538 chr16:58549086 SETD6 1.12 7.16 0.37 5.33e-12 Schizophrenia; CRC trans rs61931739 0.500 rs10772154 chr12:34373271 A/C cg26384229 chr12:38710491 ALG10B 0.61 8.98 0.44 2.18e-17 Morning vs. evening chronotype; CRC cis rs4700695 0.841 rs152995 chr5:65323172 G/A cg21114390 chr5:65439923 SFRS12 0.62 6.83 0.35 4.03e-11 Facial morphology (factor 19); CRC cis rs4423214 1.000 rs11600569 chr11:71173747 C/G cg05163923 chr11:71159392 DHCR7 0.65 9.32 0.46 1.8e-18 Vitamin D levels; CRC trans rs6600671 1.000 rs10794671 chr1:121168242 A/C cg00646200 chr1:148855367 NA 0.35 6.35 0.33 7.24e-10 Hip geometry; CRC cis rs1129187 0.720 rs9471972 chr6:42915021 G/A cg03790207 chr6:42947109 PEX6 -0.49 -7.07 -0.36 9.39e-12 Alzheimer's disease in APOE e4+ carriers; CRC cis rs9611565 0.694 rs5758347 chr22:41821019 G/T cg06634786 chr22:41940651 POLR3H 0.7 7.77 0.39 1.03e-13 Vitiligo; CRC cis rs4073416 0.518 rs2149839 chr14:65983448 G/A cg03016385 chr14:66212404 NA -0.42 -5.94 -0.31 7.06e-9 N-glycan levels; CRC cis rs9612 1.000 rs346523 chr19:44260681 A/C cg08581076 chr19:44259116 C19orf61 0.46 5.9 0.31 9.23e-9 Exhaled nitric oxide output; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg00323266 chr2:26256363 RAB10 0.48 6.23 0.32 1.45e-9 Anxiety disorder; CRC cis rs9522267 0.535 rs9522290 chr13:112233130 A/G cg14352298 chr13:112236639 NA 0.29 6.67 0.35 1.1e-10 Hepatitis; CRC cis rs6502050 0.835 rs7208673 chr17:80165908 G/C cg09264619 chr17:80180166 NA -0.34 -5.72 -0.3 2.39e-8 Life satisfaction; CRC cis rs853679 0.517 rs9368553 chr6:28082265 T/C cg06470822 chr6:28175283 NA 1.0 13.06 0.58 1.06e-31 Depression; CRC cis rs1223397 0.938 rs17700321 chr6:13280666 G/T cg00460589 chr6:13274354 PHACTR1 0.48 5.96 0.31 6.59e-9 Blood pressure; CRC cis rs2549003 0.966 rs2706385 chr5:131831766 T/G cg02551604 chr5:131831745 NA 0.6 9.4 0.46 9.61e-19 Asthma (sex interaction); CRC cis rs7605827 0.897 rs12692271 chr2:15640317 T/C cg19274914 chr2:15703543 NA 0.4 6.05 0.32 4e-9 Educational attainment (years of education); CRC cis rs12580194 1.000 rs4491341 chr12:55697838 G/A cg19537932 chr12:55886519 OR6C68 -0.57 -7.92 -0.4 3.6e-14 Cancer; CRC cis rs4604732 0.588 rs9943231 chr1:247629829 C/T cg02104434 chr1:247694406 LOC148824;OR2C3 0.54 8.15 0.41 7.85e-15 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CRC trans rs57221529 0.766 rs72706608 chr5:559203 C/T cg25482853 chr8:67687455 SGK3 1.25 15.72 0.65 6.58e-42 Lung disease severity in cystic fibrosis; CRC cis rs11711311 1.000 rs13061150 chr3:113506734 C/T cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.51 -7.04 -0.36 1.13e-11 IgG glycosylation; CRC cis rs1552244 0.882 rs17081288 chr3:10042113 A/G cg00166722 chr3:10149974 C3orf24 0.63 8.28 0.42 3.08e-15 Alzheimer's disease; CRC cis rs8060686 0.858 rs7196789 chr16:67927124 C/T cg19582491 chr16:67682965 RLTPR -0.4 -5.74 -0.3 2.13e-8 HDL cholesterol;Metabolic syndrome; CRC cis rs9322193 0.847 rs62439808 chr6:149950826 C/T cg13206674 chr6:150067644 NUP43 0.63 9.6 0.47 2.1e-19 Lung cancer; CRC cis rs9640161 0.742 rs2159236 chr7:150017214 A/G cg12556325 chr7:150026731 C7orf29;LRRC61 -0.43 -6.34 -0.33 7.44e-10 Blood protein levels;Circulating chemerin levels; CRC cis rs73001065 0.636 rs10415849 chr19:19505087 C/T cg03709012 chr19:19516395 GATAD2A 0.79 6.79 0.35 5.1e-11 LDL cholesterol; CRC cis rs4654899 1.000 rs7521675 chr1:21424070 T/C cg02927042 chr1:21476669 EIF4G3 -0.5 -7.89 -0.4 4.61e-14 Superior frontal gyrus grey matter volume; CRC cis rs1552244 1.000 rs17032299 chr3:10087638 C/T cg16606324 chr3:10149918 C3orf24 0.72 9.89 0.48 2.32e-20 Alzheimer's disease; CRC cis rs2832191 0.791 rs2065270 chr21:30485420 T/C cg24692254 chr21:30365293 RNF160 -0.71 -12.52 -0.57 1.09e-29 Dental caries; CRC cis rs7493 0.853 rs11770901 chr7:95054480 T/C cg19678392 chr7:94953810 PON1 -0.6 -7.37 -0.38 1.35e-12 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs6951245 1.000 rs78861357 chr7:1095418 C/T cg20603222 chr7:1096387 C7orf50;GPR146 -0.72 -8.67 -0.43 1.96e-16 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs6479527 0.806 rs12351292 chr9:96763271 G/A cg14459158 chr9:96720562 NA 0.41 7.49 0.38 6.39e-13 Esophageal adenocarcinoma; CRC cis rs7131987 0.801 rs962866 chr12:29434147 A/G cg09582351 chr12:29534625 ERGIC2 -0.29 -6.28 -0.33 1.08e-9 QT interval; CRC cis rs898097 0.625 rs6502017 chr17:80891135 C/T cg15664640 chr17:80829946 TBCD 0.47 7.83 0.4 6.76e-14 Breast cancer; CRC cis rs4243830 0.850 rs1064835 chr1:6585539 A/G cg05709478 chr1:6581295 PLEKHG5 0.54 6.67 0.35 1.08e-10 Body mass index; CRC trans rs2303319 0.504 rs62189046 chr2:162612371 C/G cg18122310 chr12:50236657 BCDIN3D -0.73 -6.35 -0.33 7.23e-10 Cognitive function; CRC cis rs10751667 1.000 rs7396798 chr11:970510 G/T cg23136738 chr11:925521 AP2A2 -0.52 -8.43 -0.42 1.11e-15 Alzheimer's disease (late onset); CRC trans rs561341 0.941 rs8081016 chr17:30331751 A/G cg20587970 chr11:113659929 NA -1.42 -20.26 -0.75 8.39e-60 Hip circumference adjusted for BMI; CRC cis rs7552404 0.920 rs2788654 chr1:76219569 C/T cg22875332 chr1:76189707 ACADM 0.69 10.56 0.5 1.2e-22 Blood metabolite levels;Acylcarnitine levels; CRC trans rs56292044 1.000 rs56292044 chr8:138776547 G/T cg00605270 chr1:28261552 SMPDL3B 0.43 6.31 0.33 8.81e-10 Post bronchodilator FEV1/FVC ratio in COPD; CRC trans rs11466653 0.744 rs6856416 chr4:38778573 T/C cg11403706 chr22:49042600 FAM19A5 0.62 6.11 0.32 2.76e-9 Peripheral arterial disease (traffic-related air pollution interaction); CRC trans rs2797160 1.000 rs2747722 chr6:126009629 A/G cg05039488 chr6:79577232 IRAK1BP1 0.49 7.29 0.37 2.25e-12 Endometrial cancer; CRC trans rs7395662 1.000 rs4882111 chr11:48558447 G/A cg21153622 chr11:89784906 NA -0.45 -7.24 -0.37 3.25e-12 HDL cholesterol; CRC trans rs13046373 0.905 rs4816372 chr21:32077414 A/T cg02488288 chr5:141705351 SPRY4 -0.41 -6.06 -0.32 3.71e-9 HDL cholesterol; CRC cis rs1881797 1.000 rs68059491 chr1:247683070 C/T cg18198730 chr1:247681584 NA 0.58 8.77 0.44 1.01e-16 Acute lymphoblastic leukemia (childhood); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg21437766 chr7:73498314 LIMK1 0.5 7.2 0.37 4.17e-12 Response to antipsychotic treatment; CRC cis rs736408 0.677 rs2286798 chr3:52821177 G/T cg15147215 chr3:52552868 STAB1 0.55 8.99 0.44 1.93e-17 Bipolar disorder; CRC cis rs853679 0.517 rs2281588 chr6:28072602 G/A cg02631126 chr6:28058918 ZSCAN12L1 0.3 6.09 0.32 3.18e-9 Depression; CRC cis rs1950626 0.787 rs34857222 chr14:101391354 G/T cg02351406 chr14:101447389 SNORD114-20;SNORD114-21 0.94 15.2 0.64 6.77e-40 Pelvic organ prolapse (moderate/severe); CRC cis rs4242434 0.927 rs2291234 chr8:22464390 T/C cg03733263 chr8:22462867 KIAA1967 1.04 20.06 0.74 4.98e-59 Exploratory eye movement dysfunction in schizophrenia (cognitive search score); CRC cis rs12368653 0.651 rs2307097 chr12:58195801 T/C cg00677455 chr12:58241039 CTDSP2 -0.49 -6.64 -0.34 1.26e-10 Multiple sclerosis; CRC cis rs533581 0.866 rs2968474 chr16:88970566 A/G cg05579598 chr16:88989069 CBFA2T3 -0.34 -6.73 -0.35 7.41e-11 Social autistic-like traits; CRC cis rs853679 0.517 rs6932109 chr6:28078303 A/G cg25164649 chr6:28176230 NA -0.73 -9.49 -0.46 4.87e-19 Depression; CRC cis rs12681287 0.673 rs4464946 chr8:87326259 G/A cg27223183 chr8:87520930 FAM82B -0.5 -6.64 -0.34 1.29e-10 Caudate activity during reward; CRC cis rs62229266 0.839 rs11088335 chr21:37470335 C/T cg12218747 chr21:37451666 NA -0.37 -6.24 -0.33 1.35e-9 Mitral valve prolapse; CRC cis rs25422 0.540 rs9481842 chr6:118974798 A/C cg24463073 chr6:118973353 C6orf204 0.44 6.68 0.35 9.97e-11 Renal cell carcinoma; CRC cis rs78077440 1.000 rs78077440 chr5:40323767 G/A cg09067459 chr5:40385259 NA -0.54 -5.86 -0.31 1.11e-8 Multiple sclerosis; CRC cis rs6582618 1 rs6582618 chr12:38726137 A/G cg26384229 chr12:38710491 ALG10B 0.55 7.81 0.4 7.78e-14 Morning vs. evening chronotype; CRC cis rs4665809 0.938 rs6742226 chr2:26342537 A/G cg26119090 chr2:26468346 HADHA;HADHB -0.62 -7.99 -0.4 2.3e-14 Gut microbiome composition (summer); CRC cis rs60843830 1.000 rs58461606 chr2:267367 G/T cg25945732 chr2:264204 ACP1;SH3YL1 0.72 11.77 0.54 6.32e-27 Spherical equivalent (joint analysis main effects and education interaction); CRC cis rs11758351 0.587 rs2050950 chr6:26234883 A/G cg10723962 chr6:26240782 HIST1H4F -0.39 -6.27 -0.33 1.15e-9 Gout;Renal underexcretion gout; CRC cis rs6952808 1.000 rs59248873 chr7:1888185 A/G cg05279229 chr7:1896384 MAD1L1 -0.37 -5.91 -0.31 8.66e-9 Bipolar disorder and schizophrenia; CRC trans rs1814175 0.588 rs1794144 chr11:49918233 A/G cg03929089 chr4:120376271 NA -0.91 -15.98 -0.66 6.12e-43 Height; CRC cis rs2243480 1.000 rs35825738 chr7:65318027 A/G cg12463550 chr7:65579703 CRCP 0.66 6.14 0.32 2.36e-9 Diabetic kidney disease; CRC cis rs9287719 0.649 rs2024433 chr2:10731504 G/C cg00105475 chr2:10696890 NA 0.45 7.14 0.37 6.18e-12 Prostate cancer; CRC cis rs2404602 0.583 rs2139190 chr15:76555539 G/C cg23625390 chr15:77176239 SCAPER 0.39 5.79 0.3 1.63e-8 Blood metabolite levels; CRC cis rs11105298 0.891 rs4842662 chr12:89933446 T/C cg00757033 chr12:89920650 WDR51B 0.38 6.27 0.33 1.12e-9 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; CRC cis rs12142240 0.660 rs7520497 chr1:46824919 C/A cg14993813 chr1:46806288 NSUN4 -0.49 -6.22 -0.32 1.55e-9 Menopause (age at onset); CRC trans rs7829975 0.902 rs777707 chr8:8584344 A/G cg16141378 chr3:129829833 LOC729375 -0.43 -6.53 -0.34 2.55e-10 Mood instability; CRC cis rs1448094 0.512 rs4540904 chr12:86235472 A/G cg19622623 chr12:86230825 RASSF9 -0.41 -6.7 -0.35 8.81e-11 Major depressive disorder; CRC cis rs6598955 0.724 rs7547520 chr1:26592310 C/T cg04990556 chr1:26633338 UBXN11 -0.79 -13.39 -0.59 5.94e-33 Obesity-related traits; CRC cis rs7666738 1.000 rs13124102 chr4:98990696 G/A cg17366294 chr4:99064904 C4orf37 0.45 7.33 0.37 1.78e-12 Colonoscopy-negative controls vs population controls; CRC cis rs6502050 0.731 rs4789730 chr17:80145983 T/A cg22110888 chr17:80059540 CCDC57 0.4 6.32 0.33 8.27e-10 Life satisfaction; CRC cis rs9325144 0.624 rs7312879 chr12:39150752 G/A cg26384229 chr12:38710491 ALG10B -0.49 -6.76 -0.35 6.26e-11 Morning vs. evening chronotype; CRC cis rs8180040 0.900 rs4858894 chr3:47484953 C/G cg10298567 chr3:47292165 KIF9 -0.36 -5.86 -0.31 1.12e-8 Colorectal cancer; CRC cis rs2455601 0.935 rs12049908 chr11:8919309 G/A cg09997546 chr11:8931473 C11orf17;ST5 -0.52 -6.89 -0.35 2.9100000000000002e-11 Schizophrenia; CRC cis rs41271473 0.500 rs10916366 chr1:228894575 T/C cg16512390 chr1:228756714 NA 0.39 5.67 0.3 3.13e-8 Chronic lymphocytic leukemia; CRC trans rs703108 0.731 rs7898954 chr10:22323646 A/G cg05737526 chr18:3454175 TGIF1 -0.52 -6.33 -0.33 7.81e-10 Monocyte percentage of white cells; CRC cis rs9649213 0.613 rs2286074 chr7:97952011 G/A cg00277769 chr7:97922759 BAIAP2L1 -0.61 -10.7 -0.51 4.06e-23 Prostate cancer (SNP x SNP interaction); CRC cis rs4805272 0.539 rs1075733 chr19:29324460 C/T cg12667521 chr19:29218732 NA 0.48 6.82 0.35 4.27e-11 Plasma omega-3 polyunsaturated fatty acid levels (docosahexaenoic acid); CRC cis rs9796 0.689 rs13329537 chr15:41449211 C/G cg18705301 chr15:41695430 NDUFAF1 0.36 6.03 0.32 4.44e-9 Menopause (age at onset); CRC cis rs40363 0.680 rs72778116 chr16:3530752 A/G cg00484396 chr16:3507460 NAT15 0.6 5.61 0.3 4.38e-8 Tuberculosis; CRC cis rs10927875 0.800 rs1627145 chr1:16328116 C/T cg24140574 chr1:16342155 HSPB7 0.44 5.88 0.31 1.03e-8 Dilated cardiomyopathy; CRC cis rs1816752 0.837 rs7324645 chr13:25000855 A/G cg02811702 chr13:24901961 NA 0.45 6.24 0.33 1.31e-9 Obesity-related traits; CRC cis rs9322193 0.926 rs952166 chr6:150119910 A/T cg13206674 chr6:150067644 NUP43 0.57 8.14 0.41 8.29e-15 Lung cancer; CRC trans rs11039798 1.000 rs7479655 chr11:48576714 G/T cg03929089 chr4:120376271 NA 0.61 6.01 0.31 4.8e-9 Axial length; CRC cis rs7493 0.806 rs17876090 chr7:95053404 A/T cg07404485 chr7:94953653 PON1 -0.48 -6.19 -0.32 1.84e-9 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs9938149 0.674 rs7201034 chr16:88298705 A/G cg05435882 chr16:88311214 NA -0.48 -6.28 -0.33 1.05e-9 Corneal structure;Central corneal thickness; CRC cis rs12682352 0.602 rs11783966 chr8:8665147 A/G cg06636001 chr8:8085503 FLJ10661 -0.53 -8.41 -0.42 1.3e-15 Neuroticism; CRC cis rs6860806 0.507 rs2631362 chr5:131707293 A/G cg12564285 chr5:131593104 PDLIM4 -0.45 -7.46 -0.38 7.69e-13 Breast cancer; CRC cis rs7493 0.755 rs62467350 chr7:94970114 T/C cg20119798 chr7:94954144 PON1 -0.44 -5.66 -0.3 3.37e-8 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs8177253 1.000 rs3811647 chr3:133484029 G/A cg01448562 chr3:133502909 NA -0.54 -9.16 -0.45 5.87e-18 Iron status biomarkers; CRC cis rs7659604 0.846 rs35986491 chr4:122664528 A/T cg20573242 chr4:122745356 CCNA2 0.41 6.15 0.32 2.26e-9 Type 2 diabetes; CRC cis rs67478160 0.643 rs12880167 chr14:104300829 C/T cg01849466 chr14:104193079 ZFYVE21 -0.48 -8.44 -0.42 1.01e-15 Schizophrenia; CRC cis rs1862618 0.802 rs42769 chr5:56144152 G/A cg22800045 chr5:56110881 MAP3K1 0.56 6.21 0.32 1.59e-9 Initial pursuit acceleration; CRC cis rs2235649 0.833 rs9933168 chr16:1848361 A/G cg00935504 chr16:1863053 HAGH 0.31 5.65 0.3 3.39e-8 Blood metabolite levels; CRC cis rs73200209 0.744 rs55643039 chr12:116609355 T/G cg01776926 chr12:116560359 MED13L -0.61 -7.04 -0.36 1.14e-11 Total body bone mineral density; CRC cis rs3812762 0.833 rs35670750 chr11:8782444 T/C cg21881798 chr11:8931708 C11orf17;ST5 -0.42 -6.24 -0.33 1.35e-9 Hypospadias; CRC cis rs11758351 1.000 rs78012445 chr6:26195080 G/C cg22723502 chr6:26240528 HIST1H4F -0.37 -5.78 -0.3 1.74e-8 Gout;Renal underexcretion gout; CRC trans rs2303319 0.504 rs62189043 chr2:162608466 A/T cg04551154 chr10:95462393 C10orf4 -0.75 -6.37 -0.33 6.43e-10 Cognitive function; CRC trans rs11039798 0.511 rs2047812 chr11:48162042 A/G cg15704280 chr7:45808275 SEPT13 -0.73 -7.76 -0.39 1.08e-13 Axial length; CRC cis rs1153858 0.887 rs7171163 chr15:45636395 A/C cg21132104 chr15:45694354 SPATA5L1 0.58 8.59 0.43 3.59e-16 Homoarginine levels; CRC cis rs7666738 0.830 rs9884501 chr4:98893721 A/C cg17366294 chr4:99064904 C4orf37 0.4 6.56 0.34 2.1e-10 Colonoscopy-negative controls vs population controls; CRC cis rs7246657 0.941 rs7256130 chr19:37933981 T/C cg23950597 chr19:37808831 NA -0.47 -5.82 -0.31 1.36e-8 Coronary artery calcification; CRC cis rs10504229 0.683 rs61306359 chr8:58134646 G/A cg02725872 chr8:58115012 NA -0.64 -11.55 -0.54 3.85e-26 Developmental language disorder (linguistic errors); CRC cis rs9527 0.668 rs7092815 chr10:104736345 G/T cg04362960 chr10:104952993 NT5C2 0.6 8.25 0.41 3.81e-15 Arsenic metabolism; CRC cis rs7208859 0.623 rs35916850 chr17:29011173 G/A cg13385521 chr17:29058706 SUZ12P 0.71 7.69 0.39 1.71e-13 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC trans rs3960554 0.808 rs3779419 chr7:75695081 G/A cg19862616 chr7:65841803 NCRNA00174 0.65 7.91 0.4 3.86e-14 Eotaxin levels; CRC cis rs2952156 0.920 rs8078228 chr17:37834998 C/T cg07936489 chr17:37558343 FBXL20 -0.4 -5.8 -0.3 1.53e-8 Asthma; CRC cis rs10504229 0.906 rs114810777 chr8:58185298 A/G cg24829409 chr8:58192753 C8orf71 -0.68 -11.25 -0.53 4.47e-25 Developmental language disorder (linguistic errors); CRC cis rs539096 0.500 rs803678 chr1:44350898 G/T cg12908607 chr1:44402522 ARTN -0.55 -10.11 -0.49 4.23e-21 Intelligence (multi-trait analysis); CRC cis rs4665809 0.590 rs62128455 chr2:26466530 G/A cg04944784 chr2:26401820 FAM59B 0.83 10.74 0.51 2.96e-23 Gut microbiome composition (summer); CRC cis rs13108904 0.846 rs4974574 chr4:1224811 A/G cg00684032 chr4:1343700 KIAA1530 0.42 6.33 0.33 8.09e-10 Obesity-related traits; CRC trans rs7227892 0.659 rs9959212 chr18:46342442 C/T cg04876465 chr9:35605902 TESK1 0.49 6.06 0.32 3.7e-9 Migraine with aura; CRC cis rs9322193 0.962 rs9688940 chr6:150110113 G/A cg00933542 chr6:150070202 PCMT1 0.28 5.63 0.3 3.86e-8 Lung cancer; CRC cis rs10486722 0.606 rs13237727 chr7:41802205 A/G cg22138096 chr7:41772439 LOC285954 -0.45 -6.31 -0.33 9.14e-10 Pit-and-Fissure caries; CRC cis rs11587400 0.572 rs2268699 chr1:115227896 G/T cg12756093 chr1:115239321 AMPD1 0.5 7.06 0.36 1e-11 Autism; CRC trans rs11039798 1.000 rs7928243 chr11:48589192 A/T cg03929089 chr4:120376271 NA 0.65 6.38 0.33 6.18e-10 Axial length; CRC cis rs9916302 0.904 rs6503507 chr17:37525274 C/T cg03013999 chr17:37608204 MED1 -0.47 -7.35 -0.38 1.61e-12 Glomerular filtration rate (creatinine); CRC cis rs4319547 1.000 rs6489157 chr12:123101673 C/G cg05707623 chr12:122985044 ZCCHC8 0.71 9.04 0.45 1.4e-17 Body mass index; CRC cis rs8044995 0.563 rs73615919 chr16:68398862 C/T cg09835421 chr16:68378352 PRMT7 -0.7 -7.76 -0.39 1.09e-13 Schizophrenia; CRC cis rs12928939 0.911 rs8051878 chr16:71818431 C/G cg08717414 chr16:71523259 ZNF19 -0.51 -6.35 -0.33 7.13e-10 Post bronchodilator FEV1; CRC cis rs8105895 0.932 rs28600030 chr19:22268443 G/A cg02657401 chr19:22469223 NA -0.35 -5.76 -0.3 1.94e-8 Body mass index (change over time); CRC cis rs4819052 0.851 rs7275468 chr21:46656499 C/A cg02159808 chr21:46707872 POFUT2;LOC642852 0.44 5.9 0.31 8.85e-9 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs2243480 1.000 rs316322 chr7:65611233 G/C cg18252515 chr7:66147081 NA -1.27 -14.44 -0.62 5.83e-37 Diabetic kidney disease; CRC trans rs6472235 0.778 rs6472242 chr8:66910613 T/G cg07884673 chr3:53033167 SFMBT1 -0.45 -6.24 -0.33 1.38e-9 Myopia (pathological);Plateletcrit; CRC cis rs8180040 0.966 rs7651762 chr3:47470484 G/A cg02527881 chr3:46936655 PTH1R 0.38 6.85 0.35 3.65e-11 Colorectal cancer; CRC cis rs11148252 0.875 rs7987115 chr13:52962097 C/T cg12458913 chr13:53173898 NA 0.49 7.64 0.39 2.41e-13 Lewy body disease; CRC cis rs9372498 0.536 rs9489407 chr6:118792337 A/T cg22561889 chr6:118971681 C6orf204 -0.49 -6.45 -0.33 4.11e-10 Diastolic blood pressure; CRC cis rs8072100 0.651 rs1912484 chr17:45443664 C/G cg08085267 chr17:45401833 C17orf57 -0.6 -9.41 -0.46 8.63e-19 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs611744 0.538 rs2298605 chr8:109272006 T/C cg18478394 chr8:109455254 TTC35 0.42 6.24 0.33 1.36e-9 Dupuytren's disease; CRC cis rs2243480 1.000 rs11538349 chr7:65421871 C/T cg18252515 chr7:66147081 NA -1.06 -12.43 -0.57 2.43e-29 Diabetic kidney disease; CRC trans rs853679 1.000 rs853676 chr6:28299687 C/T cg06606381 chr12:133084897 FBRSL1 -0.66 -6.68 -0.35 1.05e-10 Depression; CRC cis rs798554 0.549 rs1623138 chr7:2899410 A/G cg19717773 chr7:2847554 GNA12 -0.36 -5.72 -0.3 2.41e-8 Height; CRC cis rs12291225 0.679 rs11369 chr11:14288096 A/G cg05501817 chr11:14380813 RRAS2 -0.45 -5.91 -0.31 8.48e-9 Sense of smell; CRC cis rs6570726 1.000 rs1935617 chr6:145943326 C/T cg05347473 chr6:146136440 FBXO30 0.37 5.68 0.3 2.97e-8 Lobe attachment (rater-scored or self-reported); CRC cis rs9858542 0.953 rs6766131 chr3:49538932 T/C cg00383909 chr3:49044727 WDR6 0.44 5.68 0.3 2.91e-8 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs78761021 0.867 rs17676067 chr17:9791375 C/T cg26853458 chr17:9805074 RCVRN -0.44 -7.96 -0.4 2.78e-14 Type 2 diabetes; CRC cis rs9894429 0.646 rs7210026 chr17:79612382 T/C cg13777783 chr17:79615861 NA -0.3 -5.64 -0.3 3.71e-8 Eye color traits; CRC cis rs2688608 0.592 rs12253429 chr10:75496161 C/G cg23231163 chr10:75533350 FUT11 -0.37 -5.89 -0.31 9.32e-9 Inflammatory bowel disease; CRC cis rs2952156 0.959 rs907087 chr17:37828787 G/A cg20243544 chr17:37824526 PNMT 0.58 8.89 0.44 4.24e-17 Asthma; CRC trans rs2243480 1.000 rs1796220 chr7:66062100 C/T cg10756647 chr7:56101905 PSPH 0.75 7.84 0.4 6.2e-14 Diabetic kidney disease; CRC trans rs7690467 0.794 rs4365738 chr4:133404953 C/T cg19296258 chr17:78878799 RPTOR 0.47 6.17 0.32 2.03e-9 Eating disorders; CRC cis rs3789045 1.000 rs3789045 chr1:204586812 C/T cg17419461 chr1:204415978 PIK3C2B -0.49 -6.94 -0.36 2.05e-11 Educational attainment (college completion); CRC cis rs2625529 0.617 rs2929509 chr15:72239272 T/C cg16672083 chr15:72433130 SENP8 0.47 6.99 0.36 1.55e-11 Red blood cell count; CRC cis rs9309711 0.666 rs6723126 chr2:3484500 T/C cg08493051 chr2:3487164 NA -0.39 -5.65 -0.3 3.48e-8 Neurofibrillary tangles; CRC cis rs2153535 0.601 rs7741024 chr6:8530313 T/C cg21535247 chr6:8435926 SLC35B3 0.48 7.35 0.38 1.6e-12 Motion sickness; CRC cis rs801193 1.000 rs2707856 chr7:66211010 A/T cg11764359 chr7:65958608 NA 0.54 8.27 0.41 3.47e-15 Aortic root size; CRC cis rs12681287 0.511 rs9297923 chr8:87548989 T/C cg27223183 chr8:87520930 FAM82B 0.5 6.72 0.35 7.91e-11 Caudate activity during reward; CRC cis rs1552244 0.938 rs66915020 chr3:10110174 A/G cg02579736 chr3:10068473 FANCD2;CIDECP 0.96 12.9 0.58 4.44e-31 Alzheimer's disease; CRC cis rs7618915 0.547 rs10780035 chr3:52764624 C/T cg18404041 chr3:52824283 ITIH1 -0.43 -8.89 -0.44 4.01e-17 Bipolar disorder; CRC cis rs7843479 0.965 rs11135763 chr8:21813962 A/G cg17168535 chr8:21777572 XPO7 0.55 9.05 0.45 1.26e-17 Mean corpuscular volume; CRC cis rs7605827 0.930 rs4668923 chr2:15681227 G/A cg19274914 chr2:15703543 NA 0.39 5.82 0.31 1.4e-8 Educational attainment (years of education); CRC cis rs9911578 1.000 rs2531734 chr17:56550804 T/C cg05425664 chr17:57184151 TRIM37 0.52 8.27 0.41 3.34e-15 Intelligence (multi-trait analysis); CRC cis rs694739 0.536 rs671976 chr11:64046029 G/A cg02228329 chr11:64053129 BAD;GPR137 0.47 7.22 0.37 3.55e-12 Alopecia areata;Crohn's disease;Psoriasis vulgaris; CRC cis rs7705042 0.897 rs249681 chr5:141538017 G/C cg07392085 chr5:141489673 NDFIP1 0.46 7.31 0.37 2.01e-12 Asthma; CRC cis rs1862618 0.671 rs2255726 chr5:56243128 T/C cg03609598 chr5:56110824 MAP3K1 0.58 7.81 0.4 7.56e-14 Initial pursuit acceleration; CRC cis rs11785693 0.862 rs73183606 chr8:4986999 C/T cg26367366 chr8:4980734 NA 0.89 10.86 0.51 1.07e-23 Neuroticism (multi-trait analysis);Neuroticism; CRC trans rs875971 0.545 rs1909508 chr7:65766353 G/T cg02869306 chr7:64672164 INTS4L1 -0.44 -6.52 -0.34 2.68e-10 Aortic root size; CRC cis rs3796352 1.000 rs13078971 chr3:53103645 G/C cg07884673 chr3:53033167 SFMBT1 0.77 6.21 0.32 1.64e-9 Immune reponse to smallpox (secreted IL-2); CRC cis rs16852403 0.619 rs6685876 chr1:178135119 G/A cg00404053 chr1:178313656 RASAL2 0.6 7.64 0.39 2.36e-13 Childhood ear infection; CRC trans rs877282 0.945 rs10904554 chr10:786768 T/C cg22713356 chr15:30763199 NA 1.32 16.01 0.66 4.44e-43 Uric acid levels; CRC trans rs6472235 0.807 rs2357566 chr8:66911221 C/T cg07884673 chr3:53033167 SFMBT1 -0.46 -6.27 -0.33 1.11e-9 Myopia (pathological);Plateletcrit; CRC cis rs2204008 0.702 rs8175764 chr12:38363690 T/C cg13010199 chr12:38710504 ALG10B 0.47 6.3 0.33 9.77e-10 Bladder cancer; CRC cis rs6570726 0.967 rs413880 chr6:145804822 G/A cg05347473 chr6:146136440 FBXO30 0.37 5.87 0.31 1.04e-8 Lobe attachment (rater-scored or self-reported); CRC cis rs9300255 0.620 rs7313483 chr12:123726834 C/T cg00376283 chr12:123451042 ABCB9 0.54 7.05 0.36 1.08e-11 Neutrophil percentage of white cells; CRC cis rs2204008 0.837 rs11612397 chr12:38357455 T/C cg26384229 chr12:38710491 ALG10B 0.69 9.77 0.47 5.95e-20 Bladder cancer; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg03752689 chr1:209958185 C1orf74 0.49 7.15 0.37 5.58e-12 Response to antipsychotic treatment; CRC cis rs9911578 1.000 rs9898626 chr17:56698219 C/G cg05425664 chr17:57184151 TRIM37 -0.5 -7.95 -0.4 3.02e-14 Intelligence (multi-trait analysis); CRC cis rs7666738 0.830 rs13113899 chr4:99050422 T/C cg05340658 chr4:99064831 C4orf37 0.58 8.8 0.44 8.01e-17 Colonoscopy-negative controls vs population controls; CRC cis rs7811142 1.000 rs73405353 chr7:100091215 G/A cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.93 11.93 0.55 1.68e-27 Platelet count; CRC cis rs9486715 1.000 rs9486715 chr6:97059769 A/C cg18709589 chr6:96969512 KIAA0776 -0.55 -8.07 -0.41 1.34e-14 Headache; CRC cis rs9929218 0.551 rs2274240 chr16:68725486 A/G cg01251360 chr16:68772225 CDH1 -0.23 -5.62 -0.3 4.03e-8 Colorectal cancer; CRC cis rs853679 0.542 rs9393892 chr6:28081394 A/G cg02631126 chr6:28058918 ZSCAN12L1 0.29 5.84 0.31 1.26e-8 Depression; CRC cis rs736408 0.812 rs1076425 chr3:52825462 A/G cg11645453 chr3:52864694 ITIH4 0.44 7.17 0.37 4.9e-12 Bipolar disorder; CRC cis rs1552244 0.810 rs35711405 chr3:10116939 C/T cg00166722 chr3:10149974 C3orf24 0.7 9.53 0.46 3.69e-19 Alzheimer's disease; CRC cis rs2996428 0.561 rs2275827 chr1:3746585 T/G cg17848003 chr1:3704513 LRRC47 0.41 6.06 0.32 3.71e-9 Red cell distribution width; CRC cis rs34172651 0.917 rs11642302 chr16:24770856 G/A cg06028605 chr16:24865363 SLC5A11 0.41 7.87 0.4 5.05e-14 Intelligence (multi-trait analysis); CRC trans rs2727020 0.658 rs1851992 chr11:49438110 C/T cg11707556 chr5:10655725 ANKRD33B -0.39 -7.31 -0.37 1.99e-12 Coronary artery disease; CRC cis rs2153535 0.580 rs1414351 chr6:8476634 T/C cg21535247 chr6:8435926 SLC35B3 0.5 7.53 0.38 4.89e-13 Motion sickness; CRC cis rs2559856 0.967 rs2695290 chr12:102087844 A/G cg12924262 chr12:102091054 CHPT1 -0.54 -8.15 -0.41 7.47e-15 Blood protein levels; CRC cis rs4665809 0.567 rs12999875 chr2:26414847 A/C cg22920501 chr2:26401640 FAM59B 0.83 11.8 0.55 4.76e-27 Gut microbiome composition (summer); CRC cis rs1552244 0.572 rs17032426 chr3:10167112 G/A cg00166722 chr3:10149974 C3orf24 0.65 7.7 0.39 1.56e-13 Alzheimer's disease; CRC cis rs853679 1.000 rs2799077 chr6:28234597 C/T cg15845792 chr6:28175446 NA 0.6 6.2 0.32 1.65e-9 Depression; CRC cis rs9517320 0.967 rs9517337 chr13:99181647 A/C cg07423050 chr13:99094983 FARP1 0.44 6.7 0.35 8.79e-11 Longevity; CRC cis rs7107174 1.000 rs2512547 chr11:77960888 T/C cg02023728 chr11:77925099 USP35 0.48 7.54 0.38 4.6e-13 Testicular germ cell tumor; CRC cis rs9733 0.628 rs7540874 chr1:150702663 A/C cg17724175 chr1:150552817 MCL1 0.57 9.12 0.45 7.76e-18 Tonsillectomy; CRC cis rs7712401 0.791 rs10059964 chr5:122118293 A/G cg18764291 chr5:122110994 SNX2 0.43 6.88 0.35 2.96e-11 Mean platelet volume; CRC cis rs6951245 0.935 rs78573577 chr7:1089087 C/A cg21664854 chr7:1097933 C7orf50;GPR146 0.79 8.71 0.43 1.52e-16 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs68170813 0.559 rs4730223 chr7:106814234 A/T cg02696742 chr7:106810147 HBP1 0.58 6.71 0.35 8.6e-11 Coronary artery disease; CRC cis rs73206853 0.686 rs7139314 chr12:110923871 G/A cg12870014 chr12:110450643 ANKRD13A 0.84 9.77 0.47 5.69e-20 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC cis rs2425143 0.730 rs2095819 chr20:34353278 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.48 -6.09 -0.32 3.15e-9 Blood protein levels; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg26063087 chr22:35695661 TOM1 0.47 7.05 0.36 1.03e-11 Intelligence (multi-trait analysis); CRC cis rs9796 0.689 rs8032195 chr15:41448790 G/A cg18705301 chr15:41695430 NDUFAF1 -0.35 -5.73 -0.3 2.28e-8 Menopause (age at onset); CRC trans rs7873102 0.702 rs7028020 chr9:38007747 C/T ch.1.64660926R chr1:64888338 NA -0.4 -5.99 -0.31 5.6e-9 Brain structure; CRC cis rs7312933 0.501 rs7296357 chr12:42729891 T/G cg19980929 chr12:42632907 YAF2 -0.38 -5.82 -0.31 1.43e-8 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CRC cis rs67311347 1.000 rs4973997 chr3:40460145 G/A cg24209194 chr3:40518798 ZNF619 0.43 6.54 0.34 2.32e-10 Renal cell carcinoma; CRC cis rs2806561 0.765 rs682766 chr1:23516397 C/G cg12483005 chr1:23474871 LUZP1 0.49 7.15 0.37 5.58e-12 Height; CRC cis rs4319547 0.695 rs4758643 chr12:122924819 A/T cg05707623 chr12:122985044 ZCCHC8 -0.73 -9.2 -0.45 4.31e-18 Body mass index; CRC cis rs6930083 0.510 rs4713994 chr6:36621533 A/G cg08179530 chr6:36648295 CDKN1A -0.55 -8.32 -0.42 2.43e-15 Coronary artery disease; CRC cis rs11191205 0.686 rs61382490 chr10:103454402 A/T cg15320455 chr10:103880129 LDB1 0.56 6.0 0.31 5.16e-9 Intelligence (multi-trait analysis); CRC cis rs2019137 1.000 rs2019137 chr2:113973632 G/A cg07772999 chr2:113993052 PAX8;LOC440839;LOC654433 -0.44 -6.24 -0.33 1.36e-9 Lymphocyte counts; CRC cis rs4972806 0.814 rs1446575 chr2:177047801 A/C cg14324370 chr2:177042789 NA 0.78 12.78 0.58 1.22e-30 IgG glycosylation; CRC cis rs1707322 0.896 rs809774 chr1:46560244 T/A cg03146154 chr1:46216737 IPP -0.53 -7.26 -0.37 2.87e-12 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC trans rs61931739 0.500 rs56056630 chr12:34543465 T/C cg13010199 chr12:38710504 ALG10B 0.45 6.52 0.34 2.65e-10 Morning vs. evening chronotype; CRC cis rs7727544 0.735 rs272867 chr5:131681057 G/A cg24060327 chr5:131705240 SLC22A5 -0.37 -6.09 -0.32 3.09e-9 Blood metabolite levels; CRC cis rs6684514 1.000 rs12117903 chr1:156311165 G/T cg16558208 chr1:156270281 VHLL 0.55 8.73 0.43 1.35e-16 Mean corpuscular hemoglobin concentration;Glycated hemoglobin levels; CRC cis rs17767392 0.836 rs17178387 chr14:71997723 A/G cg13720639 chr14:72061746 SIPA1L1 -0.47 -6.24 -0.33 1.37e-9 Mitral valve prolapse; CRC cis rs2239547 0.563 rs2581820 chr3:53020544 A/G cg18404041 chr3:52824283 ITIH1 0.38 7.47 0.38 7.45e-13 Schizophrenia; CRC trans rs1656966 1.000 rs1656966 chr3:186466252 C/T cg17421506 chr11:18656159 SPTY2D1 0.4 6.01 0.31 5.01e-9 Myopia (pathological); CRC cis rs4665809 0.590 rs1368902 chr2:26440576 T/C cg04944784 chr2:26401820 FAM59B -0.83 -10.74 -0.51 2.96e-23 Gut microbiome composition (summer); CRC cis rs6502050 0.835 rs34673303 chr17:80085144 G/C cg09264619 chr17:80180166 NA 0.36 6.08 0.32 3.4e-9 Life satisfaction; CRC cis rs875971 0.545 rs1796217 chr7:66085918 A/G cg11764359 chr7:65958608 NA -0.45 -5.61 -0.3 4.37e-8 Aortic root size; CRC cis rs6964587 0.967 rs58673519 chr7:91823887 T/G cg17063962 chr7:91808500 NA 0.78 12.3 0.56 7.34e-29 Breast cancer; CRC cis rs873946 0.586 rs3793684 chr10:134568645 G/A cg26818010 chr10:134567672 INPP5A -0.71 -9.2 -0.45 4.39e-18 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CRC cis rs2024825 1 rs2024825 chr1:67597977 T/C cg17031739 chr1:67600172 NA 0.5 6.21 0.32 1.58e-9 Leprosy; CRC cis rs10504229 0.953 rs66509078 chr8:58174734 G/C cg01721255 chr8:58191610 C8orf71 0.49 6.17 0.32 2e-9 Developmental language disorder (linguistic errors); CRC cis rs2842992 0.692 rs1128661 chr6:160211554 T/G cg11366901 chr6:160182831 ACAT2 0.73 10.92 0.52 6.54e-24 Age-related macular degeneration (geographic atrophy); CRC cis rs798554 0.679 rs1639036 chr7:2885089 G/A cg19346786 chr7:2764209 NA -0.36 -6.19 -0.32 1.8e-9 Height; CRC cis rs2084637 1.000 rs12224773 chr11:122417079 T/C cg21585512 chr11:122030076 LOC399959 -0.38 -6.78 -0.35 5.47e-11 Stroke; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg19972591 chr12:120966863 COQ5 0.4 6.53 0.34 2.47e-10 Liver disease severity in Alagille syndrome; CRC cis rs2153535 0.580 rs9505467 chr6:8520219 G/A cg07606381 chr6:8435919 SLC35B3 0.64 10.53 0.5 1.54e-22 Motion sickness; CRC cis rs17253792 0.822 rs78429067 chr14:56092551 G/A cg24579896 chr14:56047964 C14orf33;KTN1 0.71 5.69 0.3 2.81e-8 Putamen volume; CRC cis rs10751667 0.643 rs7479473 chr11:929111 C/T cg06064525 chr11:970664 AP2A2 -0.33 -6.65 -0.34 1.25e-10 Alzheimer's disease (late onset); CRC cis rs6752107 0.935 rs11690131 chr2:234148383 T/C cg07618928 chr2:234183455 ATG16L1;SCARNA5 0.56 8.9 0.44 3.77e-17 Crohn's disease;Inflammatory bowel disease; CRC cis rs1799949 1.000 rs11652332 chr17:41295489 G/A cg01879757 chr17:41196368 BRCA1 -0.44 -6.67 -0.35 1.07e-10 Menopause (age at onset); CRC cis rs10504229 0.906 rs903718 chr8:58167726 A/G cg24829409 chr8:58192753 C8orf71 -0.56 -9.94 -0.48 1.53e-20 Developmental language disorder (linguistic errors); CRC cis rs9409565 0.717 rs61470662 chr9:97189472 T/C cg04523069 chr9:97136363 HIATL1 0.37 5.71 0.3 2.55e-8 Colorectal cancer (alcohol consumption interaction); CRC cis rs4665809 0.549 rs72809635 chr2:26411674 G/A cg22920501 chr2:26401640 FAM59B 0.84 10.69 0.51 4.32e-23 Gut microbiome composition (summer); CRC cis rs4664304 1.000 rs57771571 chr2:160767804 G/C cg03641300 chr2:160917029 PLA2R1 -0.42 -5.9 -0.31 9.15e-9 Crohn's disease;Inflammatory bowel disease; CRC cis rs17767392 1.000 rs725673 chr14:71878468 A/C cg13720639 chr14:72061746 SIPA1L1 -0.55 -6.95 -0.36 1.96e-11 Mitral valve prolapse; CRC cis rs1997103 0.954 rs1917769 chr7:55392325 T/A cg17469321 chr7:55412551 NA 0.74 11.48 0.53 7.1e-26 QRS interval (sulfonylurea treatment interaction); CRC cis rs909002 0.886 rs10798880 chr1:32097088 G/T cg13919466 chr1:32135498 COL16A1 -0.31 -5.95 -0.31 6.86e-9 Intelligence (multi-trait analysis); CRC cis rs35306767 0.715 rs12772979 chr10:1034412 C/T cg26597838 chr10:835615 NA 0.95 10.61 0.5 8.04e-23 Eosinophil percentage of granulocytes; CRC cis rs10927875 0.722 rs1763606 chr1:16338282 A/G cg24140574 chr1:16342155 HSPB7 0.43 5.74 0.3 2.11e-8 Dilated cardiomyopathy; CRC cis rs514406 0.505 rs12726160 chr1:53175099 A/G cg08859206 chr1:53392774 SCP2 -0.42 -6.65 -0.34 1.25e-10 Monocyte count; CRC cis rs9325144 0.723 rs11169519 chr12:39177441 G/A cg26384229 chr12:38710491 ALG10B -0.43 -5.78 -0.3 1.78e-8 Morning vs. evening chronotype; CRC cis rs7927771 1.000 rs11039390 chr11:47796295 C/G cg20307385 chr11:47447363 PSMC3 -0.5 -6.58 -0.34 1.83e-10 Subjective well-being; CRC cis rs1401999 1.000 rs6802849 chr3:183698943 A/C cg20387954 chr3:183756860 HTR3D 0.46 7.76 0.39 1.1e-13 Anterior chamber depth; CRC cis rs6121246 0.821 rs6119718 chr20:30331074 A/G cg18721089 chr20:30220636 NA -0.36 -5.86 -0.31 1.12e-8 Mean corpuscular hemoglobin; CRC cis rs9311474 0.569 rs7614981 chr3:52566914 G/T cg18099408 chr3:52552593 STAB1 -0.57 -10.94 -0.52 5.59e-24 Electroencephalogram traits; CRC cis rs17253792 0.571 rs112129578 chr14:56028415 T/C cg01858014 chr14:56050164 KTN1 -0.85 -6.59 -0.34 1.75e-10 Putamen volume; CRC trans rs4263408 0.934 rs9683743 chr4:39703194 A/C cg20567499 chr11:107730432 SLC35F2 -0.4 -6.23 -0.32 1.42e-9 Plasma amyloid beta peptide concentrations (ABx-40); CRC cis rs9291683 0.595 rs35250962 chr4:10048271 C/T cg11266682 chr4:10021025 SLC2A9 0.52 10.98 0.52 4.28e-24 Bone mineral density; CRC cis rs9747201 1.000 rs57405744 chr17:80177465 A/G cg09264619 chr17:80180166 NA -0.49 -6.9 -0.36 2.63e-11 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs17376456 0.825 rs17314762 chr5:93231200 C/T cg09848695 chr5:92956644 FAM172A;MIR2277 0.66 5.82 0.31 1.39e-8 Diabetic retinopathy; CRC cis rs853679 0.550 rs1225598 chr6:28160799 T/G cg23161317 chr6:28129485 ZNF389 0.46 6.02 0.31 4.79e-9 Depression; CRC cis rs916888 0.773 rs199443 chr17:44819565 C/T cg17911788 chr17:44343683 NA -0.61 -7.07 -0.36 9.53e-12 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs2836950 0.501 rs4818019 chr21:40694456 T/A cg06238570 chr21:40685208 BRWD1 -0.59 -8.56 -0.43 4.54e-16 Menarche (age at onset); CRC cis rs1728785 1.000 rs12918861 chr16:68566508 G/A cg02972257 chr16:68554789 NA -0.56 -6.9 -0.36 2.65e-11 Ulcerative colitis; CRC cis rs4423214 0.840 rs1792315 chr11:71165547 C/T cg05163923 chr11:71159392 DHCR7 -0.67 -8.04 -0.41 1.67e-14 Vitamin D levels; CRC cis rs67478160 0.655 rs4900598 chr14:104281541 T/C cg08213375 chr14:104286397 PPP1R13B 0.62 12.81 0.58 9.17e-31 Schizophrenia; CRC cis rs9660180 0.967 rs6603803 chr1:1812688 A/G cg23982607 chr1:1823379 GNB1 -0.91 -17.21 -0.69 8.57e-48 Body mass index; CRC cis rs7224685 0.530 rs7221574 chr17:4007543 T/C cg11204139 chr17:3907470 NA 0.5 6.38 0.33 6.16e-10 Type 2 diabetes; CRC cis rs10888329 0.708 rs6587435 chr1:248355585 T/C cg00666640 chr1:248458726 OR2T12 0.43 7.05 0.36 1.05e-11 Autism spectrum disorder; CRC cis rs853679 0.517 rs9348794 chr6:28117757 T/A cg12172441 chr6:28176163 NA 0.64 7.53 0.38 5.03e-13 Depression; CRC cis rs3820068 0.603 rs10492986 chr1:15988702 T/C cg24675056 chr1:15929824 NA 0.53 7.04 0.36 1.16e-11 Systolic blood pressure; CRC cis rs2625529 0.652 rs8036307 chr15:72175120 A/G cg16672083 chr15:72433130 SENP8 0.46 7.2 0.37 4.04e-12 Red blood cell count; CRC cis rs11711311 1.000 rs2305546 chr3:113503354 A/G cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.52 -7.07 -0.36 9.26e-12 IgG glycosylation; CRC trans rs9388451 0.626 rs2875881 chr6:126072853 C/G cg05039488 chr6:79577232 IRAK1BP1 -0.74 -12.93 -0.58 3.24e-31 Brugada syndrome; CRC cis rs6860806 0.507 rs635620 chr5:131720263 A/G cg02033258 chr5:131593261 PDLIM4 -0.39 -6.61 -0.34 1.52e-10 Breast cancer; CRC cis rs10486722 0.606 rs6949797 chr7:41802301 C/T cg22138096 chr7:41772439 LOC285954 -0.52 -6.38 -0.33 5.92e-10 Pit-and-Fissure caries; CRC cis rs11030122 0.632 rs11030599 chr11:4031677 A/G cg18678763 chr11:4115507 RRM1 -0.49 -8.21 -0.41 5.07e-15 Mean platelet volume;Platelet distribution width; CRC cis rs9910055 0.762 rs4239142 chr17:42205876 A/G cg13607699 chr17:42295918 UBTF -0.5 -6.85 -0.35 3.7e-11 Total body bone mineral density; CRC trans rs1945213 0.694 rs34828123 chr11:55837868 T/A cg15704280 chr7:45808275 SEPT13 0.55 6.15 0.32 2.25e-9 Acute lymphoblastic leukemia (childhood); CRC cis rs2204008 0.840 rs11181795 chr12:38401129 A/G cg13010199 chr12:38710504 ALG10B 0.47 6.32 0.33 8.35e-10 Bladder cancer; CRC cis rs13315871 0.929 rs1045115 chr3:58305199 C/T cg20936604 chr3:58311152 NA -0.7 -6.72 -0.35 8.01e-11 Cholesterol, total; CRC cis rs597539 0.616 rs513476 chr11:68698996 C/T cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.87 14.81 0.63 2.25e-38 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs597539 0.690 rs608810 chr11:68624118 G/C cg06028808 chr11:68637592 NA 0.41 6.34 0.33 7.53e-10 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs9733 0.596 rs6686525 chr1:150635811 C/T cg10589385 chr1:150898437 SETDB1 0.28 5.94 0.31 7.24e-9 Tonsillectomy; CRC trans rs3749237 1.000 rs11130216 chr3:49736172 C/A cg21665057 chr3:196295764 WDR53;FBXO45 0.55 7.77 0.39 1.01e-13 Resting heart rate; CRC cis rs7927592 0.701 rs12226585 chr11:68257861 A/T cg01657329 chr11:68192670 LRP5 0.57 9.43 0.46 7.72e-19 Total body bone mineral density; CRC trans rs2797160 0.967 rs1777224 chr6:126019527 T/C cg05039488 chr6:79577232 IRAK1BP1 0.52 7.52 0.38 5.17e-13 Endometrial cancer; CRC cis rs13086611 1 rs13086611 chr3:49385417 A/T cg03060546 chr3:49711283 APEH -0.5 -7.23 -0.37 3.45e-12 Educational attainment; CRC cis rs6693567 0.565 rs12093148 chr1:150265173 G/A cg15654264 chr1:150340011 RPRD2 -0.39 -5.7 -0.3 2.6e-8 Migraine; CRC cis rs2115536 1.000 rs2115536 chr15:80194247 C/T cg00225070 chr15:80189496 MTHFS 0.48 7.95 0.4 3.05e-14 Eosinophil counts;Eosinophil percentage of white cells;Sum eosinophil basophil counts;Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; CRC cis rs2797160 1.000 rs2747720 chr6:126009458 A/G cg05901451 chr6:126070800 HEY2 0.4 6.2 0.32 1.65e-9 Endometrial cancer; CRC cis rs9783347 1.000 rs1520884 chr11:18309700 C/T cg15585147 chr11:18324498 HPS5 -0.45 -6.52 -0.34 2.72e-10 Pancreatic cancer; CRC cis rs1153858 0.943 rs28605551 chr15:45641720 C/T cg10760299 chr15:45669010 GATM 0.47 7.42 0.38 9.84e-13 Homoarginine levels; CRC cis rs2836950 0.501 rs35994303 chr21:40686020 C/T cg06238570 chr21:40685208 BRWD1 -0.59 -8.4 -0.42 1.34e-15 Menarche (age at onset); CRC cis rs4423214 1.000 rs12419334 chr11:71139472 T/C cg05163923 chr11:71159392 DHCR7 0.69 9.77 0.47 5.61e-20 Vitamin D levels; CRC cis rs10911232 0.524 rs4652773 chr1:183054827 A/G ch.1.3577855R chr1:183094577 LAMC1 0.83 14.16 0.62 6.98e-36 Hypertriglyceridemia; CRC cis rs704795 0.867 rs7566052 chr2:27628635 A/G cg21248554 chr2:27665150 KRTCAP3 -0.32 -7.35 -0.38 1.59e-12 Menopause (age at onset); CRC cis rs28386778 0.897 rs2727330 chr17:61925498 A/G cg06873352 chr17:61820015 STRADA -0.71 -13.31 -0.59 1.24e-32 Prudent dietary pattern; CRC cis rs4731207 0.596 rs7788458 chr7:124630141 G/A cg23710748 chr7:124431027 NA -0.39 -6.28 -0.33 1.09e-9 Cutaneous malignant melanoma; CRC cis rs13108904 0.935 rs4974575 chr4:1252028 A/G cg21620606 chr4:1342894 KIAA1530 0.37 6.34 0.33 7.55e-10 Obesity-related traits; CRC cis rs7212590 0.748 rs7211208 chr17:57957109 A/C cg10252138 chr17:58120427 NA -0.57 -5.83 -0.31 1.34e-8 Granulocyte percentage of myeloid white cells;Monocyte count;Monocyte percentage of white cells; CRC cis rs10927875 0.722 rs1763605 chr1:16338925 T/G cg22431228 chr1:16359049 CLCNKA -0.43 -7.55 -0.38 4.24e-13 Dilated cardiomyopathy; CRC cis rs2932538 0.922 rs12402929 chr1:113072293 G/C cg22162597 chr1:113214053 CAPZA1 0.67 8.63 0.43 2.6e-16 Systolic blood pressure;Diastolic blood pressure;Hypertension;Blood pressure; CRC cis rs3858526 0.834 rs10839160 chr11:6002113 T/C cg02574844 chr11:5959923 NA -0.43 -5.69 -0.3 2.86e-8 DNA methylation (variation); CRC cis rs8180040 0.966 rs13059519 chr3:47539969 C/T cg02527881 chr3:46936655 PTH1R -0.41 -7.77 -0.39 1.04e-13 Colorectal cancer; CRC cis rs9322817 0.691 rs2499652 chr6:105269959 G/A cg02098413 chr6:105308735 HACE1 0.43 8.52 0.43 5.85e-16 Thyroid stimulating hormone; CRC cis rs1008375 0.966 rs10939736 chr4:17581617 T/A cg16339924 chr4:17578868 LAP3 0.6 8.0 0.4 2.16e-14 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs2235544 0.579 rs11804837 chr1:54482915 G/A cg25741118 chr1:54482237 LDLRAD1 -0.22 -6.32 -0.33 8.74e-10 Multiple myeloma (hyperdiploidy);Thyroid hormone levels; CRC cis rs9443645 0.901 rs1984195 chr6:79657391 G/A cg11833968 chr6:79620685 NA -0.36 -6.35 -0.33 7.34e-10 Intelligence (multi-trait analysis); CRC cis rs7044106 0.512 rs7873848 chr9:123354222 C/G cg09586646 chr9:123605570 PSMD5;LOC253039 0.56 8.08 0.41 1.25e-14 Hip circumference adjusted for BMI; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg22128035 chr2:47168977 MCFD2;TTC7A 0.45 6.22 0.32 1.51e-9 Response to antipsychotic treatment; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg11377484 chr7:128578176 IRF5 0.42 6.11 0.32 2.86e-9 Intelligence (multi-trait analysis); CRC cis rs6502050 0.835 rs6502068 chr17:80112223 C/T cg09264619 chr17:80180166 NA -0.34 -5.75 -0.3 2.03e-8 Life satisfaction; CRC cis rs736408 0.509 rs1108842 chr3:52720080 A/C cg18404041 chr3:52824283 ITIH1 -0.3 -6.13 -0.32 2.58e-9 Bipolar disorder; CRC trans rs963731 0.649 rs7571052 chr2:39189831 C/T cg13401531 chr11:70333281 SHANK2 -0.73 -6.08 -0.32 3.42e-9 Corticobasal degeneration; CRC cis rs6860806 0.507 rs200837 chr5:131699958 G/A cg27615366 chr5:131592974 PDLIM4 0.32 5.62 0.3 4.1e-8 Breast cancer; CRC cis rs2992756 0.663 rs1360916 chr1:18801697 G/A cg14356550 chr1:18808102 KLHDC7A -0.4 -5.69 -0.3 2.74e-8 Breast cancer; CRC cis rs514406 0.679 rs11206006 chr1:53218380 A/G cg24675658 chr1:53192096 ZYG11B 0.8 12.23 0.56 1.36e-28 Monocyte count; CRC cis rs2836974 0.831 rs11911149 chr21:40528375 C/T cg17971929 chr21:40555470 PSMG1 0.83 12.88 0.58 5.05e-31 Cognitive function; CRC cis rs34779708 0.801 rs12246600 chr10:35538121 A/C cg03585969 chr10:35415529 CREM 0.58 7.37 0.38 1.41e-12 Inflammatory bowel disease;Crohn's disease; CRC cis rs2949837 0.603 rs1542818 chr7:45977656 G/T cg10677697 chr7:45961126 IGFBP3 0.36 6.3 0.33 9.38e-10 Sitting height ratio; CRC cis rs35110281 0.627 rs56369437 chr21:44970275 A/G cg01579765 chr21:45077557 HSF2BP -0.33 -6.07 -0.32 3.48e-9 Mean corpuscular volume; CRC trans rs9858542 0.953 rs34588335 chr3:49407660 G/C cg21659725 chr3:3221576 CRBN -0.65 -8.96 -0.44 2.56e-17 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs8044995 0.563 rs8058517 chr16:68379860 A/G cg09835421 chr16:68378352 PRMT7 0.74 7.62 0.39 2.74e-13 Schizophrenia; CRC cis rs208520 1.000 rs208521 chr6:66953625 C/T cg07460842 chr6:66804631 NA -0.92 -11.45 -0.53 8.97e-26 Exhaled nitric oxide output; CRC cis rs11212617 1.000 rs7112136 chr11:108287131 G/A cg14761454 chr11:108092087 ATM;NPAT 0.43 6.61 0.34 1.52e-10 Response to metformin in type 2 diabetes (glycemic); CRC cis rs6964587 0.869 rs13237856 chr7:91551788 G/A cg17063962 chr7:91808500 NA -0.75 -12.81 -0.58 9.21e-31 Breast cancer; CRC cis rs4716602 0.542 rs13224561 chr7:156161063 G/A cg16983916 chr7:156159713 NA -0.39 -6.81 -0.35 4.57e-11 Anti-saccade response; CRC cis rs929596 0.755 rs3771341 chr2:234673239 G/A cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.75 -11.25 -0.53 4.7e-25 Total bilirubin levels in HIV-1 infection; CRC cis rs1577917 0.839 rs1447159 chr6:86609249 G/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.45 -5.88 -0.31 9.99e-9 Response to antipsychotic treatment; CRC cis rs4742903 0.935 rs3818626 chr9:106856633 C/T cg21169611 chr9:106856078 SMC2 0.44 6.13 0.32 2.5e-9 High-grade serous ovarian cancer;Breast cancer; CRC cis rs394563 0.589 rs1900300 chr6:149641627 T/C cg11245181 chr6:149772854 ZC3H12D 0.52 9.02 0.45 1.58e-17 Dupuytren's disease; CRC cis rs832540 0.898 rs702680 chr5:56220382 T/C cg20203395 chr5:56204925 C5orf35 -0.42 -5.82 -0.31 1.41e-8 Coronary artery disease; CRC cis rs7487075 0.606 rs4768714 chr12:46814245 T/A cg22049899 chr12:47219821 SLC38A4 0.32 5.8 0.3 1.58e-8 Itch intensity from mosquito bite; CRC cis rs7659604 1.000 rs10005932 chr4:122664782 T/C cg19748678 chr4:122722346 EXOSC9 0.54 8.55 0.43 4.7e-16 Type 2 diabetes; CRC cis rs9905704 0.846 rs304298 chr17:56839689 G/A cg12560992 chr17:57184187 TRIM37 0.55 7.95 0.4 2.94e-14 Testicular germ cell tumor; CRC cis rs875971 1.000 rs1363055 chr7:65943275 A/G cg18912574 chr7:65842487 NCRNA00174 0.36 6.1 0.32 2.97e-9 Aortic root size; CRC cis rs4819052 0.851 rs8127834 chr21:46696109 G/A cg19498844 chr21:46707878 POFUT2;LOC642852 0.8 11.74 0.54 7.83e-27 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs10861342 0.892 rs12227605 chr12:105501100 G/A cg23923672 chr12:105501055 KIAA1033 0.62 5.85 0.31 1.21e-8 IgG glycosylation; CRC cis rs2933343 0.700 rs789238 chr3:128636715 A/G cg11901034 chr3:128598214 ACAD9 -0.56 -8.18 -0.41 6.46e-15 IgG glycosylation; CRC cis rs11641365 0.678 rs877579 chr16:88770621 A/G cg27087555 chr16:88793112 FAM38A -0.51 -5.86 -0.31 1.1e-8 Autism spectrum disorder-related traits; CRC cis rs951366 0.764 rs708725 chr1:205744138 G/T cg24503407 chr1:205819492 PM20D1 0.83 13.04 0.58 1.3e-31 Menarche (age at onset); CRC cis rs853679 0.517 rs9380057 chr6:28104634 G/T cg03623178 chr6:28175578 NA 0.96 12.57 0.57 7.23e-30 Depression; CRC cis rs4563143 0.663 rs10406794 chr19:29228056 C/T cg04546413 chr19:29218101 NA 0.43 6.83 0.35 4.12e-11 Methadone dose in opioid dependence; CRC cis rs9926296 0.609 rs4785709 chr16:89796665 G/A cg27121462 chr16:89883253 FANCA -0.39 -5.75 -0.3 1.99e-8 Vitiligo; CRC cis rs17270561 0.609 rs2275905 chr6:25768106 G/A cg16482183 chr6:26056742 HIST1H1C 0.71 9.0 0.44 1.79e-17 Iron status biomarkers; CRC cis rs208520 0.661 rs7747492 chr6:66857788 A/T cg07460842 chr6:66804631 NA -1.06 -14.8 -0.63 2.51e-38 Exhaled nitric oxide output; CRC cis rs4665809 0.887 rs4665825 chr2:26333100 A/G cg26119090 chr2:26468346 HADHA;HADHB -0.62 -7.97 -0.4 2.58e-14 Gut microbiome composition (summer); CRC cis rs1395 0.744 rs11686131 chr2:27508710 C/T cg14242246 chr2:27434262 C2orf28;SLC5A6 0.35 5.83 0.31 1.3e-8 Blood metabolite levels; CRC trans rs459571 0.629 rs441233 chr9:136876021 A/G cg15028160 chr19:49622717 PPFIA3;C19orf73 0.58 7.53 0.38 4.96e-13 Platelet distribution width; CRC cis rs1186222 0.902 rs1179629 chr7:75262613 G/T cg05145297 chr7:75264568 HIP1 0.54 9.86 0.48 2.81e-20 Basophil percentage of granulocytes;White blood cell count (basophil);Basophil percentage of white cells; CRC cis rs9640161 0.789 rs1464753 chr7:150021350 G/C cg13722127 chr7:150037890 RARRES2 0.49 7.68 0.39 1.82e-13 Blood protein levels;Circulating chemerin levels; CRC cis rs8044995 0.563 rs3785127 chr16:68399590 C/G cg05110241 chr16:68378359 PRMT7 -0.76 -7.78 -0.39 9.23e-14 Schizophrenia; CRC cis rs933688 0.877 rs1477349 chr5:90707773 G/A cg26981201 chr5:90679533 LOC100129716;ARRDC3 1.02 15.59 0.65 1.97e-41 Smoking behavior; CRC cis rs870825 0.860 rs55974219 chr4:185600733 G/A cg04058563 chr4:185651563 MLF1IP 0.63 6.52 0.34 2.71e-10 Blood protein levels; CRC cis rs6088580 0.634 rs6059829 chr20:33017074 G/A cg24642439 chr20:33292090 TP53INP2 0.37 6.27 0.33 1.12e-9 Glomerular filtration rate (creatinine); CRC cis rs1707322 1.000 rs4606257 chr1:46307268 G/A cg03146154 chr1:46216737 IPP 0.59 8.19 0.41 5.66e-15 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs7666738 0.800 rs12163918 chr4:98835794 T/C cg05340658 chr4:99064831 C4orf37 0.54 7.8 0.4 8.28e-14 Colonoscopy-negative controls vs population controls; CRC cis rs9322193 0.884 rs62439837 chr6:149991516 G/T cg13206674 chr6:150067644 NUP43 0.64 9.07 0.45 1.13e-17 Lung cancer; CRC cis rs10504229 0.683 rs56408763 chr8:58137276 G/A cg24829409 chr8:58192753 C8orf71 -0.55 -8.03 -0.4 1.71e-14 Developmental language disorder (linguistic errors); CRC cis rs9611565 0.592 rs9611612 chr22:41961189 T/C cg06634786 chr22:41940651 POLR3H -0.53 -6.33 -0.33 8.02e-10 Vitiligo; CRC cis rs8060686 0.641 rs76595854 chr16:68130233 T/C cg08314208 chr16:67682810 RLTPR -0.58 -6.23 -0.32 1.47e-9 HDL cholesterol;Metabolic syndrome; CRC cis rs5758511 0.680 rs5758662 chr22:42628088 T/C cg00645731 chr22:42541494 CYP2D7P1 0.66 10.14 0.49 3.45e-21 Birth weight; CRC cis rs8177253 1.000 rs8177247 chr3:133479499 T/G cg01448562 chr3:133502909 NA -0.54 -9.42 -0.46 8.33e-19 Iron status biomarkers; CRC cis rs7927771 1.000 rs35624992 chr11:47615798 G/C cg20307385 chr11:47447363 PSMC3 -0.55 -7.75 -0.39 1.19e-13 Subjective well-being; CRC cis rs7618915 0.532 rs13060675 chr3:52674300 T/G cg08222913 chr3:52553049 STAB1 -0.34 -6.14 -0.32 2.4e-9 Bipolar disorder; CRC cis rs2735413 0.875 rs12925138 chr16:78083923 C/T cg04733911 chr16:78082701 NA -0.45 -7.54 -0.38 4.5e-13 Systolic blood pressure (alcohol consumption interaction); CRC cis rs7208859 0.524 rs60114476 chr17:29097667 A/T cg13385521 chr17:29058706 SUZ12P 0.73 8.33 0.42 2.14e-15 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs12410462 0.901 rs16847844 chr1:227638110 A/G cg23173402 chr1:227635558 NA 0.69 8.24 0.41 4.22e-15 Major depressive disorder; CRC cis rs853679 0.585 rs201004 chr6:27804934 T/C cg20933634 chr6:27740509 NA 0.58 6.89 0.36 2.86e-11 Depression; CRC cis rs17253792 0.822 rs76164147 chr14:56140369 T/C cg01858014 chr14:56050164 KTN1 -0.88 -7.22 -0.37 3.55e-12 Putamen volume; CRC cis rs6460942 0.749 rs74834695 chr7:12464779 G/A cg06484146 chr7:12443880 VWDE -0.78 -8.1 -0.41 1.11e-14 Coronary artery disease; CRC cis rs939658 0.805 rs939661 chr15:79431063 A/G cg17916960 chr15:79447300 NA -0.45 -7.3 -0.37 2.14e-12 Refractive error; CRC cis rs950169 1.000 rs79318564 chr15:84786150 G/A cg24253500 chr15:84953950 NA 0.38 6.42 0.33 4.71e-10 Schizophrenia; CRC cis rs2204008 0.506 rs11495470 chr12:38026904 C/T cg13010199 chr12:38710504 ALG10B 0.46 6.1 0.32 3.03e-9 Bladder cancer; CRC cis rs4481887 0.830 rs28581861 chr1:248506028 T/G cg13385794 chr1:248469461 NA 0.35 6.39 0.33 5.79e-10 Common traits (Other); CRC cis rs9325144 0.560 rs61929893 chr12:38653366 G/A cg13010199 chr12:38710504 ALG10B -0.42 -6.12 -0.32 2.7e-9 Morning vs. evening chronotype; CRC cis rs9322193 0.923 rs9322209 chr6:150012362 A/G cg07701084 chr6:150067640 NUP43 0.56 8.29 0.42 2.98e-15 Lung cancer; CRC cis rs2439831 1.000 rs7173487 chr15:43750239 A/G cg15269541 chr15:43626905 ADAL -0.56 -6.66 -0.34 1.14e-10 Lung cancer in ever smokers; CRC cis rs4240897 1.000 rs4240897 chr1:12042755 A/G cg13216073 chr1:12042593 MFN2 -0.54 -8.45 -0.42 9.54e-16 Tuberculosis; CRC cis rs6502050 0.814 rs9894554 chr17:80073423 C/G cg02741985 chr17:80059408 CCDC57 -0.45 -7.27 -0.37 2.63e-12 Life satisfaction; CRC cis rs12701220 0.655 rs9638973 chr7:1133678 A/G cg26769984 chr7:1090371 C7orf50 0.5 6.84 0.35 3.99e-11 Bronchopulmonary dysplasia; CRC trans rs12478296 0.901 rs56318767 chr2:243046591 T/A cg18288967 chr1:45987694 PRDX1 0.68 7.43 0.38 9.51e-13 Obesity-related traits; CRC cis rs7613875 0.600 rs2856238 chr3:50158191 C/T cg24308560 chr3:49941425 MST1R -0.4 -6.21 -0.32 1.6e-9 Body mass index; CRC trans rs75246769 1.000 rs6954312 chr7:145604258 A/G cg14916917 chr5:81574294 RPS23 0.8 5.97 0.31 6.06e-9 Facial morphology (factor 10, width of nasal floor); CRC cis rs7020830 0.898 rs7038219 chr9:37182892 C/A cg14294708 chr9:37120828 ZCCHC7 1.06 20.23 0.74 1.04e-59 Schizophrenia; CRC cis rs4423214 1.000 rs11600860 chr11:71164019 T/C cg05163923 chr11:71159392 DHCR7 0.67 9.53 0.46 3.69e-19 Vitamin D levels; CRC cis rs1862618 0.671 rs2591956 chr5:56244604 G/A cg24531977 chr5:56204891 C5orf35 0.66 10.23 0.49 1.71e-21 Initial pursuit acceleration; CRC cis rs921968 0.608 rs11678428 chr2:219352598 C/T cg02176678 chr2:219576539 TTLL4 0.5 8.04 0.41 1.65e-14 Mean corpuscular hemoglobin concentration; CRC cis rs7937682 0.883 rs553632 chr11:111462897 C/T cg19812747 chr11:111475976 SIK2 -0.57 -9.72 -0.47 8.51e-20 Primary sclerosing cholangitis; CRC cis rs9303280 0.806 rs4795399 chr17:38061439 T/C cg00129232 chr17:37814104 STARD3 -0.48 -7.52 -0.38 5.31e-13 Self-reported allergy; CRC cis rs2228479 0.867 rs62052187 chr16:89973071 G/A cg12064134 chr16:90016061 DEF8 -0.57 -5.63 -0.3 3.85e-8 Skin colour saturation; CRC cis rs4664293 0.867 rs13428679 chr2:160593198 A/G cg08347373 chr2:160653686 CD302 -0.47 -7.43 -0.38 9.32e-13 Monocyte percentage of white cells; CRC cis rs354033 0.959 rs4727082 chr7:149228110 C/T cg24335155 chr7:149193227 ZNF746 0.39 6.19 0.32 1.82e-9 Multiple sclerosis; CRC cis rs62229266 0.652 rs7280551 chr21:37409609 T/A cg08632701 chr21:37451849 NA -0.4 -6.27 -0.33 1.16e-9 Mitral valve prolapse; CRC cis rs873946 0.504 rs3793681 chr10:134564451 T/C cg06453172 chr10:134556979 INPP5A -0.62 -8.12 -0.41 9.36e-15 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CRC cis rs344364 0.602 rs2437745 chr16:1908431 G/C cg14074117 chr16:1909714 C16orf73 -0.35 -6.06 -0.32 3.66e-9 Glomerular filtration rate in chronic kidney disease; CRC cis rs4819052 1.000 rs2297286 chr21:46707897 C/G cg19498844 chr21:46707878 POFUT2;LOC642852 0.87 11.32 0.53 2.51e-25 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs8177253 0.606 rs6787177 chr3:133450720 C/T cg01448562 chr3:133502909 NA -0.41 -6.55 -0.34 2.17e-10 Iron status biomarkers; CRC cis rs11677416 1.000 rs6542092 chr2:113528322 C/G cg06156847 chr2:113672199 IL1F7 -0.39 -5.96 -0.31 6.34e-9 Response to antipsychotic treatment in schizophrenia (working memory); CRC cis rs7772486 0.727 rs2235481 chr6:146056848 T/C cg05347473 chr6:146136440 FBXO30 -0.48 -6.94 -0.36 2.15e-11 Lobe attachment (rater-scored or self-reported); CRC cis rs2280018 0.526 rs2941257 chr16:15166445 T/C cg27102117 chr16:15229624 NA 0.5 8.41 0.42 1.26e-15 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid);Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CRC cis rs17818399 0.510 rs1451153 chr2:46799852 G/T cg26688816 chr2:46740690 ATP6V1E2 -0.49 -7.54 -0.38 4.74e-13 Height; CRC cis rs4689592 0.503 rs3857180 chr4:7073899 T/G cg19539972 chr4:7069911 GRPEL1 -0.81 -9.0 -0.44 1.79e-17 Monocyte percentage of white cells; CRC cis rs950169 1.000 rs12916348 chr15:84765527 C/T cg11189052 chr15:85197271 WDR73 0.61 9.0 0.44 1.87e-17 Schizophrenia; CRC cis rs936229 0.861 rs7176022 chr15:75107880 G/T cg14664628 chr15:75095509 CSK 1.01 21.01 0.76 9.38e-63 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); CRC cis rs8062405 1.000 rs62037365 chr16:28868962 C/G cg16576597 chr16:28551801 NUPR1 0.48 6.87 0.35 3.31e-11 Cognitive ability (multi-trait analysis);Cognitive ability; CRC cis rs425277 0.606 rs2459984 chr1:2086312 A/G cg04315214 chr1:2043799 PRKCZ -0.34 -5.9 -0.31 9.15e-9 Height; CRC cis rs2463822 0.858 rs2463836 chr11:62126494 A/G cg06239285 chr11:62104954 ASRGL1 0.96 11.01 0.52 3.29e-24 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs8062405 0.824 rs62034326 chr16:28539293 A/G cg05139728 chr16:28306816 SBK1 -0.33 -5.63 -0.3 3.77e-8 Cognitive ability (multi-trait analysis);Cognitive ability; CRC trans rs4843747 0.671 rs28451517 chr16:88109127 A/C cg26811252 chr16:29126840 RRN3P2 0.66 8.78 0.44 9.11e-17 Menopause (age at onset); CRC cis rs10540 1.000 rs10540 chr11:494662 G/A cg08200582 chr11:442649 ANO9 -0.71 -7.42 -0.38 9.82e-13 Body mass index; CRC cis rs73200209 0.744 rs61939683 chr12:116508474 T/G cg01776926 chr12:116560359 MED13L -0.65 -7.69 -0.39 1.71e-13 Total body bone mineral density; CRC cis rs587080 0.559 rs12364730 chr11:65228278 C/T cg17120908 chr11:65337727 SSSCA1 -0.7 -7.65 -0.39 2.19e-13 Plateletcrit; CRC cis rs7762018 1.000 rs4716378 chr6:170086568 G/C cg17545662 chr6:170176663 C6orf70 0.55 6.11 0.32 2.88e-9 Thiazide-induced adverse metabolic effects in hypertensive patients; CRC cis rs9858542 0.953 rs9837341 chr3:49664767 A/G cg03060546 chr3:49711283 APEH -0.52 -7.01 -0.36 1.32e-11 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs734999 0.505 rs10797438 chr1:2540262 C/T cg20673091 chr1:2541236 MMEL1 0.36 5.93 0.31 7.76e-9 Ulcerative colitis; CRC trans rs7618501 1.000 rs11716575 chr3:49744890 A/G cg21665057 chr3:196295764 WDR53;FBXO45 -0.86 -16.09 -0.66 2.29e-43 Intelligence (multi-trait analysis); CRC cis rs6988636 1.000 rs60362869 chr8:124189971 A/G cg27053337 chr8:124217698 FAM83A 0.46 7.02 0.36 1.3e-11 Urinary uromodulin levels; CRC cis rs798554 0.704 rs798531 chr7:2770067 G/C cg13628971 chr7:2884303 GNA12 0.44 6.79 0.35 5.26e-11 Height; CRC cis rs7503807 1.000 rs7503807 chr17:78591111 G/T cg09596252 chr17:78655493 RPTOR -0.39 -5.96 -0.31 6.61e-9 Obesity; CRC cis rs2404602 1.000 rs11072603 chr15:76881138 G/T cg03037974 chr15:76606532 NA 0.6 9.93 0.48 1.7e-20 Blood metabolite levels; CRC cis rs1348850 0.519 rs1544002 chr2:178529534 C/T cg02961200 chr2:178257176 LOC100130691;AGPS 0.52 7.22 0.37 3.68e-12 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs4819052 0.851 rs8126930 chr21:46671715 A/G cg02159808 chr21:46707872 POFUT2;LOC642852 0.52 7.11 0.36 7.31e-12 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs10479542 0.752 rs12658664 chr5:178986987 C/T cg14820908 chr5:178986412 RUFY1 0.37 6.33 0.33 8.26e-10 Lung cancer; CRC cis rs2836974 0.897 rs11911112 chr21:40528346 A/C cg11890956 chr21:40555474 PSMG1 1.1 21.19 0.76 1.86e-63 Cognitive function; CRC cis rs1005224 0.654 rs8005753 chr14:76136086 A/T cg25116370 chr14:76127843 TTLL5;C14orf1 -0.44 -6.89 -0.36 2.81e-11 Large artery stroke; CRC cis rs12142240 0.698 rs58162700 chr1:46816659 T/A cg14993813 chr1:46806288 NSUN4 -0.5 -6.4 -0.33 5.38e-10 Menopause (age at onset); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg26797661 chr1:151138516 LYSMD1;SCNM1 0.41 6.03 0.32 4.41e-9 Response to antipsychotic treatment; CRC cis rs2070488 0.775 rs7644530 chr3:38558316 C/T cg01465620 chr3:38496096 LOC100128640;ACVR2B -0.74 -12.44 -0.57 2.29e-29 Electrocardiographic conduction measures; CRC cis rs2011503 0.882 rs10423874 chr19:19359500 C/G cg11584989 chr19:19387371 SF4 0.49 6.08 0.32 3.24e-9 Bipolar disorder; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg21222826 chr3:69062762 C3orf64 -0.4 -6.1 -0.32 2.93e-9 Myopia (pathological); CRC cis rs55665837 0.961 rs11023237 chr11:14500334 G/A cg19336497 chr11:14380999 RRAS2 -0.38 -6.49 -0.34 3.18e-10 Vitamin D levels; CRC cis rs7945705 0.712 rs61876274 chr11:9019190 A/T cg21881798 chr11:8931708 C11orf17;ST5 0.57 9.06 0.45 1.21e-17 Hemoglobin concentration; CRC cis rs1046896 0.562 rs2380172 chr17:80887719 C/A cg19500275 chr17:80737654 TBCD 0.5 6.85 0.35 3.53e-11 Glycated hemoglobin levels; CRC cis rs6951245 1.000 rs77760339 chr7:1083927 G/T cg20603222 chr7:1096387 C7orf50;GPR146 -0.68 -7.91 -0.4 4e-14 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs13191362 1.000 rs35103567 chr6:163183400 G/A cg23758597 chr6:163146217 PARK2 -0.68 -7.02 -0.36 1.29e-11 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs9325144 0.600 rs61931871 chr12:38829889 G/A cg26384229 chr12:38710491 ALG10B -0.5 -7.14 -0.37 6.04e-12 Morning vs. evening chronotype; CRC cis rs1008375 0.863 rs4590022 chr4:17614434 T/C cg16339924 chr4:17578868 LAP3 0.49 6.38 0.33 5.98e-10 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs868943 0.512 rs72953957 chr6:116546543 A/G cg18764771 chr6:116381957 FRK 0.24 5.67 0.3 3.18e-8 Total cholesterol levels; CRC cis rs6543140 0.964 rs6543143 chr2:103085420 A/C cg03938978 chr2:103052716 IL18RAP 0.41 6.52 0.34 2.71e-10 Blood protein levels; CRC cis rs1865760 0.865 rs2164485 chr6:25952106 G/A cg16482183 chr6:26056742 HIST1H1C 0.55 7.99 0.4 2.25e-14 Height; CRC trans rs3858526 0.959 rs1840179 chr11:5949148 A/G cg01505111 chr6:125621795 HDDC2 0.38 6.0 0.31 5.3300000000000004e-09 DNA methylation (variation); CRC cis rs34779708 0.931 rs4934702 chr10:35323074 T/C cg03585969 chr10:35415529 CREM 0.65 8.78 0.44 9.01e-17 Inflammatory bowel disease;Crohn's disease; CRC cis rs10504229 0.683 rs79262965 chr8:58129826 G/T cg08219700 chr8:58056026 NA 0.57 6.86 0.35 3.5e-11 Developmental language disorder (linguistic errors); CRC cis rs11971779 0.527 rs4379397 chr7:139043385 G/A cg07862535 chr7:139043722 LUC7L2 0.57 7.35 0.38 1.61e-12 Diisocyanate-induced asthma; CRC trans rs10504229 0.953 rs66815941 chr8:58187306 C/T cg04077850 chr5:125800366 GRAMD3 0.37 6.27 0.33 1.15e-9 Developmental language disorder (linguistic errors); CRC trans rs17685 0.753 rs2868203 chr7:75680026 G/A cg19862616 chr7:65841803 NCRNA00174 -0.99 -18.63 -0.72 2.21e-53 Coffee consumption;Coffee consumption (cups per day); CRC cis rs644799 0.648 rs1016031 chr11:95473365 C/T cg03916912 chr11:95522834 CEP57;FAM76B -0.56 -8.3 -0.42 2.8e-15 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs2077654 0.556 rs2299638 chr11:17443587 A/G cg25308976 chr11:17434268 ABCC8 -0.6 -6.81 -0.35 4.56e-11 Gout; CRC cis rs7493 1.000 rs7786401 chr7:95034001 G/T cg04155289 chr7:94953770 PON1 -0.62 -7.79 -0.39 9.1e-14 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs6456156 0.774 rs6931530 chr6:167527200 A/C cg19688584 chr6:167529678 CCR6 -0.35 -6.37 -0.33 6.33e-10 Primary biliary cholangitis; CRC cis rs1949733 1.000 rs1949733 chr4:8503359 C/T cg13073564 chr4:8508604 NA 0.47 6.93 0.36 2.17e-11 Response to antineoplastic agents; CRC cis rs311392 0.554 rs2666883 chr8:55100897 A/G cg06042504 chr8:55087323 NA -0.37 -5.86 -0.31 1.14e-8 Pelvic organ prolapse (moderate/severe); CRC cis rs72634258 0.554 rs17374292 chr1:7881234 C/T cg26816564 chr1:7831052 VAMP3 0.82 9.39 0.46 1.03e-18 Inflammatory bowel disease; CRC cis rs6912958 0.781 rs6940150 chr6:88287114 T/C cg08069147 chr6:88032118 GJB7;C6orf162 -0.57 -8.57 -0.43 4.19e-16 Monocyte percentage of white cells; CRC cis rs2635047 0.638 rs2571010 chr18:44652130 A/G cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.37 5.71 0.3 2.57e-8 Educational attainment; CRC trans rs7647973 0.626 rs1078341 chr3:49685592 A/G cg21665057 chr3:196295764 WDR53;FBXO45 -0.6 -6.81 -0.35 4.67e-11 Menarche (age at onset); CRC trans rs6762477 0.748 rs34877766 chr3:50234126 A/G cg21659725 chr3:3221576 CRBN 0.44 6.7 0.35 9.28e-11 Menarche (age at onset); CRC cis rs172166 0.694 rs188105 chr6:28071393 C/T cg23161317 chr6:28129485 ZNF389 0.46 6.46 0.34 3.68e-10 Cardiac Troponin-T levels; CRC trans rs60843830 1.000 rs62114544 chr2:269679 C/T cg11347411 chr7:150020925 ACTR3C;LRRC61 0.59 9.19 0.45 4.51e-18 Spherical equivalent (joint analysis main effects and education interaction); CRC cis rs7914558 0.932 rs4307650 chr10:104959852 C/A cg04362960 chr10:104952993 NT5C2 0.59 8.56 0.43 4.46e-16 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs734999 0.545 rs7364820 chr1:2556709 G/A cg20673091 chr1:2541236 MMEL1 0.37 5.94 0.31 7.18e-9 Ulcerative colitis; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg03130627 chr6:159240554 EZR 0.41 6.41 0.33 4.93e-10 Liver disease severity in Alagille syndrome; CRC cis rs11628318 0.763 rs11623312 chr14:103022060 G/T cg02094049 chr14:103021097 NA -0.51 -6.48 -0.34 3.44e-10 Platelet count; CRC cis rs9381040 0.655 rs6903444 chr6:41014220 C/T cg25110423 chr6:41068646 NFYA;LOC221442 0.38 5.66 0.3 3.22e-8 Alzheimer's disease (late onset); CRC cis rs2153535 0.504 rs5001323 chr6:8451605 C/T cg07606381 chr6:8435919 SLC35B3 0.68 10.87 0.51 9.81e-24 Motion sickness; CRC cis rs10927875 0.541 rs1048334 chr1:16340761 T/C cg22431228 chr1:16359049 CLCNKA -0.38 -6.8 -0.35 4.93e-11 Dilated cardiomyopathy; CRC trans rs853679 0.546 rs200952 chr6:27836976 C/T cg06606381 chr12:133084897 FBRSL1 -0.77 -6.6 -0.34 1.66e-10 Depression; CRC cis rs526821 0.595 rs4938937 chr11:55305507 T/A cg04317927 chr11:55418816 OR4S2 0.39 6.54 0.34 2.35e-10 Pediatric bone mineral density (spine); CRC cis rs919433 0.929 rs4850788 chr2:198182940 G/A cg20885578 chr2:198174922 NA -0.39 -6.94 -0.36 2.14e-11 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC cis rs612683 0.602 rs12565245 chr1:101019326 T/G cg06223162 chr1:101003688 GPR88 0.36 6.47 0.34 3.49e-10 Breast cancer; CRC cis rs7760949 0.889 rs9475807 chr6:13934597 T/C cg27413430 chr6:13925136 RNF182 0.33 5.76 0.3 1.91e-8 Mean corpuscular hemoglobin concentration; CRC cis rs763121 0.853 rs35522482 chr22:39063015 C/A cg06544989 chr22:39130855 UNC84B 0.46 7.11 0.37 7.19e-12 Menopause (age at onset); CRC cis rs736408 0.609 rs1029871 chr3:52797634 G/C cg15147215 chr3:52552868 STAB1 -0.62 -10.13 -0.49 3.46e-21 Bipolar disorder; CRC cis rs4332037 0.510 rs58673065 chr7:1885600 A/G cg23378565 chr7:2036160 MAD1L1 -0.38 -6.34 -0.33 7.47e-10 Bipolar disorder; CRC cis rs3996993 0.621 rs60120296 chr6:52732547 G/T cg20803780 chr6:52668592 GSTA1 0.39 6.77 0.35 5.79e-11 Hemoglobin concentration; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg17967426 chr5:168006763 PANK3 0.43 6.14 0.32 2.44e-9 Response to antipsychotic treatment; CRC cis rs6545883 0.894 rs6545867 chr2:61651027 C/T cg15711740 chr2:61764176 XPO1 0.44 5.91 0.31 8.59e-9 Tuberculosis; CRC cis rs4665809 0.531 rs10199898 chr2:26445485 T/G cg04944784 chr2:26401820 FAM59B -0.83 -10.74 -0.51 2.96e-23 Gut microbiome composition (summer); CRC cis rs1619661 0.530 rs1623851 chr10:44691241 C/T cg09554077 chr10:44749378 NA -0.52 -7.8 -0.4 8.18e-14 QT interval (ambient particulate matter interaction); CRC cis rs12594515 0.904 rs8032875 chr15:45998010 A/C cg01629716 chr15:45996671 NA 0.41 8.34 0.42 2.13e-15 Waist circumference;Weight; CRC cis rs4713118 0.869 rs9461401 chr6:27703291 G/A cg12273811 chr6:28175739 NA 0.53 7.64 0.39 2.4e-13 Parkinson's disease; CRC cis rs1997103 1.000 rs2177802 chr7:55410789 G/A cg17469321 chr7:55412551 NA 0.72 11.28 0.53 3.48e-25 QRS interval (sulfonylurea treatment interaction); CRC cis rs9916302 0.904 rs8076546 chr17:37555403 G/A cg15445000 chr17:37608096 MED1 -0.4 -8.69 -0.43 1.77e-16 Glomerular filtration rate (creatinine); CRC cis rs7726839 0.507 rs60068988 chr5:597668 T/C cg17948913 chr5:572064 NA 0.5 5.79 0.3 1.61e-8 Obesity-related traits; CRC cis rs2239547 0.603 rs7644973 chr3:53082937 C/T cg05573699 chr3:52720067 GNL3;PBRM1 -0.44 -5.66 -0.3 3.28e-8 Schizophrenia; CRC trans rs561341 1.000 rs560132 chr17:30320019 C/T cg20587970 chr11:113659929 NA -1.4 -20.09 -0.74 3.83e-59 Hip circumference adjusted for BMI; CRC cis rs4332037 0.707 rs62435130 chr7:1890002 C/T cg13880726 chr7:1868755 MAD1L1 -0.42 -5.66 -0.3 3.31e-8 Bipolar disorder; CRC cis rs7666738 0.830 rs3907020 chr4:99038583 T/C cg17366294 chr4:99064904 C4orf37 0.43 7.16 0.37 5.31e-12 Colonoscopy-negative controls vs population controls; CRC cis rs1799949 0.930 rs3765640 chr17:41276247 A/G cg25072359 chr17:41440525 NA 0.46 6.93 0.36 2.19e-11 Menopause (age at onset); CRC cis rs7072216 0.881 rs2182169 chr10:100148004 T/C cg26618903 chr10:100175079 PYROXD2 -0.37 -6.2 -0.32 1.72e-9 Metabolite levels; CRC cis rs9311474 0.967 rs610060 chr3:52273421 G/A cg08222913 chr3:52553049 STAB1 0.34 6.26 0.33 1.21e-9 Electroencephalogram traits; CRC cis rs2073300 0.609 rs6132605 chr20:23354839 A/C cg12062639 chr20:23401060 NAPB 0.71 6.7 0.35 9.01e-11 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs919433 0.889 rs788004 chr2:198219032 C/T cg03934865 chr2:198174659 NA 0.36 5.85 0.31 1.21e-8 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC cis rs7493 1.000 rs2299264 chr7:95046708 C/T cg04155289 chr7:94953770 PON1 -0.6 -7.67 -0.39 1.96e-13 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs1862618 0.853 rs2113078 chr5:56087190 C/T cg12311346 chr5:56204834 C5orf35 -0.79 -10.4 -0.5 4.49e-22 Initial pursuit acceleration; CRC cis rs12541635 0.737 rs736627 chr8:107100285 C/T cg10147462 chr8:107024639 NA -0.38 -6.07 -0.32 3.56e-9 Age of smoking initiation; CRC trans rs9858542 0.953 rs9859556 chr3:49455986 G/T cg21665057 chr3:196295764 WDR53;FBXO45 -0.6 -8.11 -0.41 1e-14 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs17125944 0.556 rs7152229 chr14:53313405 T/C cg00686598 chr14:53173677 PSMC6 -0.61 -5.8 -0.3 1.55e-8 Alzheimer's disease (late onset); CRC cis rs11105298 0.891 rs10858871 chr12:89871613 G/A cg00757033 chr12:89920650 WDR51B 0.36 6.06 0.32 3.83e-9 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; CRC cis rs1448094 0.512 rs7302741 chr12:86237127 C/T cg25456477 chr12:86230367 RASSF9 0.36 6.23 0.32 1.46e-9 Major depressive disorder; CRC cis rs4332037 0.826 rs4721188 chr7:1953615 G/A cg23422044 chr7:1970798 MAD1L1 0.54 6.9 0.36 2.66e-11 Bipolar disorder; CRC cis rs10504229 1.000 rs67237174 chr8:58175776 T/C cg05313129 chr8:58192883 C8orf71 -0.47 -7.0 -0.36 1.45e-11 Developmental language disorder (linguistic errors); CRC cis rs17539620 0.624 rs62432743 chr6:154836214 T/G cg20019720 chr6:154832845 CNKSR3 0.5 8.15 0.41 7.48e-15 Lipoprotein (a) levels; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg07279281 chr3:46735319 ALS2CL 0.4 6.25 0.33 1.26e-9 Liver disease severity in Alagille syndrome; CRC cis rs2072510 0.900 rs2110762 chr12:96402534 T/C cg22491680 chr12:96389547 HAL -0.39 -6.05 -0.32 4.03e-9 Metabolite levels (small molecules and protein measures); CRC cis rs10128264 0.902 rs1250588 chr10:80980169 T/C cg20744163 chr10:80999841 ZMIZ1 -0.43 -7.39 -0.38 1.19e-12 Response to methotrexate in juvenile idiopathic arthritis; CRC cis rs57221529 0.713 rs12521091 chr5:590710 G/T cg16447950 chr5:562315 NA -0.8 -10.38 -0.5 4.94e-22 Lung disease severity in cystic fibrosis; CRC cis rs6988985 0.560 rs4736346 chr8:143951849 G/T cg10324643 chr8:143916377 GML 0.39 6.71 0.35 8.43e-11 Plasma androstenedione levels in resected early stage-receptor positive breast cancer; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg08475953 chr5:178004091 COL23A1 0.23 6.61 0.34 1.56e-10 Liver disease severity in Alagille syndrome; CRC cis rs4713118 0.739 rs2893931 chr6:27748010 G/A cg19041857 chr6:27730383 NA -0.44 -5.94 -0.31 7.12e-9 Parkinson's disease; CRC cis rs4727027 0.933 rs12532104 chr7:148864233 A/C cg23583168 chr7:148888333 NA -0.92 -16.19 -0.67 9.15e-44 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC cis rs9488822 0.636 rs6937104 chr6:116375302 A/G cg15226275 chr6:116381976 FRK 0.31 8.8 0.44 8.03e-17 Cholesterol, total;LDL cholesterol; CRC trans rs2303319 0.504 rs55821334 chr2:162452014 A/G cg10272801 chr16:14013773 ERCC4 -0.68 -6.01 -0.31 4.9e-9 Cognitive function; CRC cis rs457287 0.614 rs531122 chr9:4830849 A/G cg14182974 chr9:4791918 RCL1 -0.35 -5.71 -0.3 2.5e-8 Platelet count; CRC cis rs9916302 0.851 rs612209 chr17:37442713 G/C cg00129232 chr17:37814104 STARD3 0.55 8.16 0.41 6.95e-15 Glomerular filtration rate (creatinine); CRC cis rs6495122 0.644 rs62029217 chr15:75261899 C/T cg14664628 chr15:75095509 CSK -0.53 -7.61 -0.39 2.87e-13 Caffeine consumption;Diastolic blood pressure;Coffee consumption; CRC cis rs7705042 0.865 rs6580228 chr5:141510448 C/T cg07392085 chr5:141489673 NDFIP1 0.46 7.23 0.37 3.48e-12 Asthma; CRC cis rs7584330 0.554 rs2325838 chr2:238386515 C/A cg14458575 chr2:238380390 NA 0.81 10.68 0.51 4.56e-23 Prostate cancer; CRC cis rs9322193 0.923 rs10872651 chr6:150089409 A/T cg07701084 chr6:150067640 NUP43 0.57 7.83 0.4 6.56e-14 Lung cancer; CRC cis rs34891900 0.507 rs738133 chr22:18205557 C/T cg19898043 chr22:18121309 BCL2L13 0.53 8.44 0.42 9.98e-16 Sum neutrophil eosinophil counts; CRC cis rs4665809 0.652 rs2241739 chr2:26411894 C/T cg22920501 chr2:26401640 FAM59B -0.8 -11.74 -0.54 7.93e-27 Gut microbiome composition (summer); CRC cis rs6540559 1.000 rs4844895 chr1:209958580 T/C cg25204440 chr1:209979598 IRF6 0.48 6.22 0.32 1.52e-9 Cleft lip with or without cleft palate; CRC trans rs1005277 0.579 rs2474580 chr10:38398713 G/A cg11292332 chr7:45801988 SEPT13 -0.35 -6.26 -0.33 1.19e-9 Extrinsic epigenetic age acceleration; CRC cis rs372883 0.530 rs2832305 chr21:30752964 G/A cg08807101 chr21:30365312 RNF160 0.48 6.94 0.36 2.08e-11 Pancreatic cancer; CRC cis rs6502050 0.604 rs9897355 chr17:80078095 G/A cg13198984 chr17:80129470 CCDC57 -0.46 -7.99 -0.4 2.25e-14 Life satisfaction; CRC cis rs950776 0.518 rs62008194 chr15:78813805 G/T cg06917634 chr15:78832804 PSMA4 0.67 10.79 0.51 1.89e-23 Sudden cardiac arrest; CRC cis rs8180040 0.903 rs2276854 chr3:47276968 C/T cg27129171 chr3:47204927 SETD2 0.72 12.02 0.55 7.7e-28 Colorectal cancer; CRC cis rs834811 0.865 rs844327 chr7:135898043 G/T cg01726295 chr7:135938950 NA 0.36 6.36 0.33 6.68e-10 Post-traumatic stress disorder; CRC cis rs501120 1.000 rs487465 chr10:44758197 A/C cg09554077 chr10:44749378 NA 0.78 12.0 0.55 9.18e-28 Coronary artery disease;Coronary heart disease; CRC cis rs1003719 0.680 rs2835670 chr21:38581114 T/C cg10648535 chr21:38446584 PIGP;TTC3 -0.45 -6.28 -0.33 1.05e-9 Eye color traits; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg17864206 chr1:43855683 C1orf84;MED8 0.39 6.01 0.31 4.91e-9 Liver disease severity in Alagille syndrome; CRC cis rs2737618 0.722 rs2737673 chr1:200081710 T/C cg21825944 chr1:200113062 NR5A2 -0.47 -6.5 -0.34 3.06e-10 Uric acid levels; CRC cis rs7927771 0.965 rs3817335 chr11:47643891 T/A cg18512352 chr11:47633146 NA -0.46 -9.15 -0.45 6.06e-18 Subjective well-being; CRC cis rs10992471 0.528 rs7037194 chr9:95216745 G/A cg14631576 chr9:95140430 CENPP -0.31 -5.63 -0.3 3.78e-8 Visceral adipose tissue/subcutaneous adipose tissue ratio; CRC cis rs55702914 0.650 rs6715690 chr2:198148371 C/T cg03934865 chr2:198174659 NA -0.36 -6.17 -0.32 1.95e-9 Major depression and alcohol dependence; CRC cis rs9291683 0.935 rs1860911 chr4:10275057 C/T cg00071950 chr4:10020882 SLC2A9 0.52 9.51 0.46 4.18e-19 Bone mineral density; CRC cis rs9534288 0.797 rs4337200 chr13:46531749 G/A cg15192986 chr13:46630673 CPB2 -0.64 -9.35 -0.46 1.38e-18 Blood protein levels; CRC cis rs1865760 0.566 rs3752420 chr6:26027135 G/A cg16482183 chr6:26056742 HIST1H1C 0.53 7.67 0.39 1.94e-13 Height; CRC cis rs2463822 0.669 rs72919484 chr11:62043430 T/C cg06239285 chr11:62104954 ASRGL1 -0.86 -8.51 -0.42 6.38e-16 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs4862750 0.758 rs2375915 chr4:187896255 A/C cg22105103 chr4:187893119 NA 0.63 11.44 0.53 9.84e-26 Lobe attachment (rater-scored or self-reported); CRC cis rs7773004 0.905 rs6932584 chr6:26327081 A/C cg00631329 chr6:26305371 NA -0.4 -6.89 -0.36 2.86e-11 Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for body mass index;Waist circumference adjusted for BMI in non-smokers;Waist circumference adjusted for BMI (adjusted for smoking behaviour); CRC trans rs561341 0.769 rs559228 chr17:30294527 T/C cg20587970 chr11:113659929 NA -1.43 -20.42 -0.75 2e-60 Hip circumference adjusted for BMI; CRC cis rs754466 0.830 rs61854186 chr10:79703255 G/A cg17075019 chr10:79541650 NA -0.74 -10.36 -0.5 6.08e-22 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs854572 1.000 rs854572 chr7:94954696 C/G cg20119798 chr7:94954144 PON1 -0.75 -13.35 -0.59 8.81e-33 Paraoxonase activity; CRC cis rs9549367 0.756 rs3861723 chr13:113910926 A/G cg18105134 chr13:113819100 PROZ -0.69 -10.54 -0.5 1.41e-22 Platelet distribution width; CRC trans rs916888 0.773 rs199457 chr17:44795469 C/T cg22968622 chr17:43663579 NA 1.4 18.15 0.71 1.65e-51 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs7762018 0.655 rs2184194 chr6:170148394 C/T cg17545662 chr6:170176663 C6orf70 0.57 6.45 0.34 3.99e-10 Thiazide-induced adverse metabolic effects in hypertensive patients; CRC cis rs2732480 0.557 rs923397 chr12:48720392 G/A cg21466736 chr12:48725269 NA -0.6 -9.04 -0.45 1.4e-17 Hemoglobin concentration;Red blood cell count;Hematocrit; CRC cis rs9905704 0.918 rs302867 chr17:56752819 C/T cg12560992 chr17:57184187 TRIM37 -0.57 -7.99 -0.4 2.28e-14 Testicular germ cell tumor; CRC cis rs453301 0.658 rs9650616 chr8:8869199 T/G cg20400248 chr8:9005257 PPP1R3B -0.38 -5.91 -0.31 8.44e-9 Joint mobility (Beighton score); CRC cis rs2070488 0.695 rs6599201 chr3:38476614 A/G cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.75 13.14 0.59 5.3e-32 Electrocardiographic conduction measures; CRC cis rs2882667 0.690 rs700623 chr5:138098682 A/G cg09476006 chr5:138032270 NA -0.59 -10.73 -0.51 3.06e-23 Age-related hearing impairment (SNP x SNP interaction); CRC trans rs7395662 0.857 rs11040074 chr11:48856726 C/T cg21153622 chr11:89784906 NA -0.48 -7.59 -0.39 3.43e-13 HDL cholesterol; CRC cis rs9916302 0.904 rs68178216 chr17:37526241 A/C cg15445000 chr17:37608096 MED1 -0.42 -9.25 -0.45 2.82e-18 Glomerular filtration rate (creatinine); CRC cis rs55823223 0.564 rs9894009 chr17:73850414 C/T cg24416660 chr17:73865998 NA -0.38 -5.76 -0.3 1.91e-8 Psoriasis; CRC cis rs970548 1.000 rs58865519 chr10:46010891 C/A cg15590007 chr10:45870220 ALOX5 0.51 6.5 0.34 3e-10 Total cholesterol levels;Cholesterol, total;HDL cholesterol;HDL cholesterol levels; CRC cis rs7493 0.853 rs17166879 chr7:95053415 A/G cg17330251 chr7:94953956 PON1 -0.6 -7.49 -0.38 6.26e-13 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs13108904 0.967 rs11247987 chr4:1294532 G/A cg02018176 chr4:1364513 KIAA1530 0.47 7.7 0.39 1.5700000000000001e-13 Obesity-related traits; CRC cis rs7527798 0.592 rs10863461 chr1:207840776 C/T cg21110645 chr1:207815933 NA -0.42 -6.61 -0.34 1.57e-10 Erythrocyte sedimentation rate; CRC cis rs360798 0.512 rs1420018 chr2:63112500 A/G cg17519650 chr2:63277830 OTX1 0.48 6.73 0.35 7.66e-11 Coronary artery disease; CRC cis rs6951245 0.935 rs79143504 chr7:1110212 A/G cg21664854 chr7:1097933 C7orf50;GPR146 0.77 8.4 0.42 1.36e-15 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs778371 0.871 rs2675954 chr2:233750627 C/G cg25237894 chr2:233734115 C2orf82 -0.4 -5.71 -0.3 2.48e-8 Schizophrenia; CRC cis rs897984 0.683 rs72799316 chr16:30827205 A/G cg00531865 chr16:30841666 NA -0.52 -7.81 -0.4 7.99e-14 Dementia with Lewy bodies; CRC cis rs9303280 0.806 rs4795399 chr17:38061439 T/C cg20243544 chr17:37824526 PNMT 0.39 5.84 0.31 1.24e-8 Self-reported allergy; CRC cis rs7113874 0.589 rs1374262 chr11:8458749 A/G cg02811074 chr11:8615871 STK33 0.35 6.0 0.31 5.28e-9 Body mass index in physically active individuals;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs614226 1.000 rs1167725 chr12:120968559 A/T cg27489772 chr12:121021490 NA 0.49 6.91 0.36 2.53e-11 Type 1 diabetes nephropathy; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg16655837 chr10:32636197 EPC1 0.4 6.42 0.33 4.63e-10 Liver disease severity in Alagille syndrome; CRC cis rs1580019 0.520 rs6945238 chr7:32646096 C/T cg06627557 chr7:32535165 LSM5;AVL9 -0.91 -14.72 -0.63 4.79e-38 Cognitive ability; CRC cis rs7607369 0.536 rs13032993 chr2:219666377 T/C cg02176678 chr2:219576539 TTLL4 -0.41 -6.7 -0.35 9.16e-11 Red blood cell count;Amyotrophic lateral sclerosis; CRC cis rs9303280 0.870 rs1011082 chr17:38068514 T/C cg00129232 chr17:37814104 STARD3 0.43 6.74 0.35 7.25e-11 Self-reported allergy; CRC cis rs3018066 0.867 rs12650692 chr4:107199842 C/T cg01869342 chr4:106983673 TBCK 0.37 5.79 0.3 1.61e-8 Cancer; CRC cis rs5769765 0.720 rs138820 chr22:50164078 A/G cg04121214 chr22:50244548 NA 0.41 6.27 0.33 1.16e-9 Schizophrenia; CRC cis rs8105895 0.877 rs9973249 chr19:22242160 T/A cg02657401 chr19:22469223 NA -0.34 -5.65 -0.3 3.56e-8 Body mass index (change over time); CRC cis rs8040855 0.542 rs2342122 chr15:85728535 C/G cg10818794 chr15:86012489 AKAP13 0.41 6.4 0.33 5.3e-10 Bulimia nervosa; CRC cis rs875971 1.000 rs10215948 chr7:65747786 G/A cg11764359 chr7:65958608 NA -0.61 -9.83 -0.48 3.71e-20 Aortic root size; CRC cis rs926938 0.527 rs360666 chr1:115481290 C/T cg12756093 chr1:115239321 AMPD1 0.49 7.26 0.37 2.84e-12 Autism; CRC trans rs9822411 0.623 rs17016204 chr3:25367141 C/T cg06260789 chr22:41741977 ZC3H7B -0.48 -6.02 -0.31 4.77e-9 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; CRC cis rs919433 0.889 rs6711624 chr2:198207607 C/G cg03934865 chr2:198174659 NA -0.39 -6.14 -0.32 2.41e-9 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC cis rs875971 0.928 rs6970357 chr7:65968878 T/C cg18876405 chr7:65276391 NA 0.51 8.78 0.44 9.39e-17 Aortic root size; CRC cis rs9649213 0.593 rs2158553 chr7:97951131 G/A cg00277769 chr7:97922759 BAIAP2L1 -0.61 -10.7 -0.51 4.06e-23 Prostate cancer (SNP x SNP interaction); CRC cis rs13108904 0.870 rs4974542 chr4:1250908 A/G cg00684032 chr4:1343700 KIAA1530 0.46 6.88 0.35 3.02e-11 Obesity-related traits; CRC cis rs10078 0.571 rs890977 chr5:476910 T/C cg07599136 chr5:415885 AHRR 0.72 7.0 0.36 1.4e-11 Fat distribution (HIV); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg10858225 chr5:141303120 KIAA0141 0.44 6.04 0.32 4.22e-9 Response to antipsychotic treatment; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg01751188 chr22:23412225 RTDR1;GNAZ 0.47 6.03 0.32 4.5e-9 Thyroid stimulating hormone; CRC cis rs11098499 0.863 rs28718422 chr4:120466304 C/A cg09307838 chr4:120376055 NA 0.67 10.3 0.49 9.15e-22 Corneal astigmatism; CRC cis rs6674176 0.561 rs4660263 chr1:44421433 A/C cg13606994 chr1:44402422 ARTN -0.36 -5.99 -0.31 5.5e-9 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Cognitive ability; CRC cis rs2836974 0.932 rs73221193 chr21:40554693 C/T cg06238570 chr21:40685208 BRWD1 0.79 10.83 0.51 1.41e-23 Cognitive function; CRC cis rs7520050 0.751 rs2230657 chr1:46073489 G/A cg06784218 chr1:46089804 CCDC17 -0.34 -5.66 -0.3 3.25e-8 Red blood cell count;Reticulocyte count; CRC cis rs10865541 1.000 rs11684337 chr2:3395287 A/G cg22182287 chr2:3452347 TTC15 -0.37 -5.76 -0.3 1.95e-8 Obesity-related traits; CRC cis rs7120118 0.517 rs3758668 chr11:47270775 C/T cg25783544 chr11:47291846 MADD 0.64 5.76 0.3 1.92e-8 HDL cholesterol; CRC cis rs12620999 0.941 rs1986830 chr2:237978320 C/T cg23555395 chr2:238036564 NA 0.55 8.41 0.42 1.29e-15 Systemic lupus erythematosus; CRC cis rs875971 0.508 rs6947808 chr7:66045082 A/G cg18876405 chr7:65276391 NA -0.59 -10.62 -0.51 7.52e-23 Aortic root size; CRC cis rs5753618 0.561 rs4141404 chr22:31675185 A/C cg07713946 chr22:31675144 LIMK2 -0.39 -5.63 -0.3 3.94e-8 Colorectal cancer; CRC cis rs2073300 0.609 rs6137930 chr20:23376732 G/A cg12062639 chr20:23401060 NAPB 0.74 6.78 0.35 5.43e-11 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs1046896 0.731 rs8067667 chr17:80785875 A/G cg03160526 chr17:80928410 B3GNTL1 0.58 7.68 0.39 1.81e-13 Glycated hemoglobin levels; CRC trans rs1493916 0.748 rs1845386 chr18:31318256 C/G cg27147174 chr7:100797783 AP1S1 -0.38 -6.06 -0.32 3.75e-9 Life satisfaction; CRC trans rs208520 0.874 rs208456 chr6:66907942 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.9 -11.28 -0.53 3.66e-25 Exhaled nitric oxide output; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg06577604 chr3:184279443 EPHB3 0.45 6.12 0.32 2.64e-9 Response to antipsychotic treatment; CRC cis rs1065656 0.619 rs2492883 chr16:1902105 C/T cg09830162 chr16:1889614 FAHD1;C16orf73 -0.55 -8.05 -0.41 1.55e-14 Insulin-like growth factors; CRC cis rs9682041 0.561 rs1477211 chr3:170140792 A/G cg11886554 chr3:170076028 SKIL 0.66 7.53 0.38 5.03e-13 Glomerular filtration rate in non diabetics (creatinine);Glomerular filtration rate (creatinine); CRC cis rs28386778 0.863 rs894414 chr17:61916384 T/C cg25654072 chr17:61904446 PSMC5;FTSJ3 0.72 11.16 0.52 9.37e-25 Prudent dietary pattern; CRC cis rs4819052 0.765 rs2838854 chr21:46680364 A/G cg19498844 chr21:46707878 POFUT2;LOC642852 0.78 11.35 0.53 2.09e-25 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs6712932 1.000 rs1978821 chr2:105833235 C/T cg20265528 chr2:105853269 NA -0.32 -5.68 -0.3 2.96e-8 Type 2 diabetes; CRC cis rs79349575 0.749 rs519537 chr17:46971140 G/A cg00947319 chr17:47005597 UBE2Z -0.34 -5.87 -0.31 1.06e-8 Type 2 diabetes; CRC cis rs1003719 0.708 rs2000417 chr21:38502868 C/T cg10648535 chr21:38446584 PIGP;TTC3 -0.48 -6.7 -0.35 8.99e-11 Eye color traits; CRC cis rs10189230 0.904 rs13029372 chr2:222348434 A/G cg14652038 chr2:222343519 EPHA4 0.54 10.31 0.49 8.68e-22 Urate levels in lean individuals; CRC cis rs926938 0.527 rs360665 chr1:115478503 A/T cg12756093 chr1:115239321 AMPD1 0.48 7.09 0.36 8.36e-12 Autism; CRC cis rs4499344 0.604 rs259275 chr19:33159693 A/G cg08127369 chr19:33164662 ANKRD27 0.39 5.95 0.31 6.82e-9 Mean platelet volume; CRC cis rs12477438 0.520 rs2516830 chr2:99773702 T/G cg14399236 chr2:99771627 LIPT1;TSGA10 0.73 12.17 0.56 2.24e-28 Chronic sinus infection; CRC cis rs9527 0.590 rs11191540 chr10:104822809 G/C cg04362960 chr10:104952993 NT5C2 0.58 8.29 0.42 2.82e-15 Arsenic metabolism; CRC cis rs4290604 0.748 rs80306906 chr2:237998886 T/G cg23555395 chr2:238036564 NA 0.65 6.67 0.35 1.09e-10 Asthma; CRC cis rs2952156 1.000 rs2934967 chr17:37870378 G/A cg20243544 chr17:37824526 PNMT 0.54 8.08 0.41 1.23e-14 Asthma; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg25842470 chr1:2472373 NA -0.46 -7.23 -0.37 3.3e-12 Liver disease severity in Alagille syndrome; CRC cis rs6964587 1.000 rs7785095 chr7:91640773 A/T cg17063962 chr7:91808500 NA -0.81 -14.46 -0.62 5.16e-37 Breast cancer; CRC cis rs9660180 1.000 rs3737628 chr1:1722932 C/T cg13866156 chr1:1669148 SLC35E2 -0.61 -9.45 -0.46 6.61e-19 Body mass index; CRC cis rs3106136 0.967 rs282448 chr4:95141411 T/G cg11021082 chr4:95130006 SMARCAD1 -0.46 -7.18 -0.37 4.6e-12 Capecitabine sensitivity; CRC cis rs2249694 0.922 rs8192780 chr10:135354125 T/G cg16964102 chr10:135390573 NA -0.37 -6.0 -0.31 5.18e-9 Obesity-related traits; CRC trans rs11088226 0.681 rs1134747 chr21:33939011 T/A cg09050820 chr6:167586206 TCP10L2 0.81 8.55 0.43 4.61e-16 Gastritis; CRC cis rs2742417 1.000 rs2673034 chr3:45755138 A/G cg04837898 chr3:45731254 SACM1L -0.35 -5.73 -0.3 2.26e-8 Response to anti-depressant treatment in major depressive disorder; CRC cis rs7727544 0.735 rs272875 chr5:131674888 T/C cg24060327 chr5:131705240 SLC22A5 -0.37 -5.97 -0.31 6.11e-9 Blood metabolite levels; CRC cis rs1691799 0.899 rs1168322 chr12:66743769 C/T cg16791601 chr12:66731901 HELB -0.73 -12.99 -0.58 1.92e-31 White blood cell count (basophil); CRC cis rs1344694 0.566 rs13029765 chr2:216894976 A/T cg25588852 chr2:216877276 MREG -0.32 -6.05 -0.32 4.01e-9 Alcohol dependence; CRC trans rs9784649 1.000 rs9784649 chr5:25011524 G/A cg11038491 chr20:34638489 LOC647979 -0.63 -7.36 -0.38 1.53e-12 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs9487051 0.676 rs4406271 chr6:109598213 G/A cg21918786 chr6:109611834 NA -0.41 -7.17 -0.37 4.84e-12 Reticulocyte fraction of red cells; CRC cis rs514406 0.861 rs505444 chr1:53251860 C/T cg27535305 chr1:53392650 SCP2 -0.36 -6.48 -0.34 3.31e-10 Monocyte count; CRC cis rs9302635 0.513 rs8050238 chr16:72154187 C/T cg23815491 chr16:72088622 HP 0.47 5.98 0.31 5.93e-9 Blood protein levels; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg01290701 chr5:82373336 XRCC4;TMEM167A 0.43 6.12 0.32 2.6e-9 Response to antipsychotic treatment; CRC cis rs7772486 0.686 rs9403741 chr6:146030548 G/A cg23711669 chr6:146136114 FBXO30 -0.66 -11.0 -0.52 3.68e-24 Lobe attachment (rater-scored or self-reported); CRC cis rs76878669 0.561 rs7948058 chr11:66148111 T/A cg18002602 chr11:66138449 SLC29A2 -0.32 -6.68 -0.35 1.02e-10 Educational attainment (years of education); CRC cis rs9291683 0.669 rs887733 chr4:10183108 T/C cg11266682 chr4:10021025 SLC2A9 -0.37 -6.99 -0.36 1.52e-11 Bone mineral density; CRC cis rs7589728 0.844 rs2363010 chr2:88496399 G/C cg07952391 chr2:88470173 THNSL2 0.62 5.95 0.31 7.01e-9 Plasma clusterin levels; CRC cis rs8141529 0.509 rs7287124 chr22:29239157 A/G cg15103426 chr22:29168792 CCDC117 0.49 6.56 0.34 2.06e-10 Lymphocyte counts; CRC cis rs2243480 1.000 rs316317 chr7:65613637 G/T cg18252515 chr7:66147081 NA -1.27 -14.59 -0.63 1.57e-37 Diabetic kidney disease; CRC cis rs9322193 0.923 rs10782310 chr6:149943594 A/G cg07701084 chr6:150067640 NUP43 0.53 7.87 0.4 5.09e-14 Lung cancer; CRC cis rs2739330 0.791 rs4822458 chr22:24265659 C/T cg11060661 chr22:24314208 DDT;DDTL 0.49 8.53 0.43 5.33e-16 Liver enzyme levels (gamma-glutamyl transferase); CRC trans rs12310956 0.532 rs10844712 chr12:33961022 G/A cg26384229 chr12:38710491 ALG10B 0.48 6.53 0.34 2.51e-10 Morning vs. evening chronotype; CRC cis rs853679 0.550 rs1225599 chr6:28165190 C/T cg06470822 chr6:28175283 NA 1.01 15.38 0.65 1.29e-40 Depression; CRC cis rs514406 0.861 rs12141260 chr1:53300127 C/T cg25767906 chr1:53392781 SCP2 -0.42 -6.76 -0.35 6.19e-11 Monocyte count; CRC cis rs7727544 0.606 rs11950562 chr5:131652529 A/C cg11843238 chr5:131593191 PDLIM4 0.33 6.09 0.32 3.16e-9 Blood metabolite levels; CRC cis rs12681288 0.862 rs7814070 chr8:1020991 A/G cg08648136 chr8:956695 NA 0.32 6.35 0.33 7.03e-10 Schizophrenia; CRC cis rs9303280 0.806 rs11078927 chr17:38064405 C/T cg20243544 chr17:37824526 PNMT 0.38 5.83 0.31 1.34e-8 Self-reported allergy; CRC trans rs3780486 0.846 rs3824458 chr9:33144809 C/T cg20290983 chr6:43655470 MRPS18A 1.17 24.9 0.81 1.13e-77 IgG glycosylation; CRC cis rs12545109 0.800 rs2610058 chr8:57409120 G/A cg09654669 chr8:57350985 NA -0.41 -5.71 -0.3 2.51e-8 Obesity-related traits; CRC cis rs72634258 0.945 rs17367289 chr1:8053135 C/T cg00042356 chr1:8021962 PARK7 -0.58 -7.01 -0.36 1.35e-11 Inflammatory bowel disease; CRC cis rs950776 0.647 rs495956 chr15:78869930 C/T cg06917634 chr15:78832804 PSMA4 -0.55 -8.22 -0.41 4.76e-15 Sudden cardiac arrest; CRC cis rs9443645 0.869 rs9343848 chr6:79621101 C/T cg11833968 chr6:79620685 NA -0.37 -6.4 -0.33 5.25e-10 Intelligence (multi-trait analysis); CRC cis rs2153535 0.580 rs7742689 chr6:8452433 C/A cg21535247 chr6:8435926 SLC35B3 0.5 7.45 0.38 8.15e-13 Motion sickness; CRC trans rs1814175 0.645 rs28454367 chr11:50045708 G/A cg15704280 chr7:45808275 SEPT13 -0.93 -17.08 -0.69 2.88e-47 Height; CRC cis rs6088590 0.561 rs6088528 chr20:33156742 G/A cg24642439 chr20:33292090 TP53INP2 0.39 6.74 0.35 7.22e-11 Coronary artery disease; CRC trans rs6951245 1.000 rs78523927 chr7:1089458 T/C cg13565492 chr6:43139072 SRF -0.71 -7.12 -0.37 7.03e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs11674184 0.659 rs59129126 chr2:11728388 T/C cg07314298 chr2:11723111 GREB1 -0.69 -12.31 -0.56 6.7200000000000006e-29 Endometriosis; CRC cis rs3733585 0.781 rs4292328 chr4:9970962 C/T cg11266682 chr4:10021025 SLC2A9 -0.51 -10.53 -0.5 1.53e-22 Cleft plate (environmental tobacco smoke interaction); CRC cis rs10986311 0.706 rs7854989 chr9:127133584 T/C cg14243010 chr9:127117328 LOC100129034;PSMB7 0.43 6.45 0.33 4.04e-10 Vitiligo; CRC cis rs1552244 0.938 rs56274701 chr3:10167790 G/A cg08888203 chr3:10149979 C3orf24 0.7 9.58 0.47 2.4e-19 Alzheimer's disease; CRC cis rs921968 0.565 rs12612395 chr2:219621642 G/C cg02176678 chr2:219576539 TTLL4 -0.43 -6.85 -0.35 3.55e-11 Mean corpuscular hemoglobin concentration; CRC cis rs1878931 0.507 rs35214904 chr16:3410017 C/A cg02880119 chr16:3481970 NA 0.44 6.07 0.32 3.57e-9 Body mass index (adult); CRC trans rs4824093 0.610 rs3761496 chr22:50246466 T/C cg09872104 chr7:134855509 C7orf49 -0.85 -7.57 -0.39 3.81e-13 Amyotrophic lateral sclerosis (sporadic); CRC cis rs7412746 0.611 rs7556661 chr1:150892009 C/T cg10589385 chr1:150898437 SETDB1 0.32 6.88 0.35 3.04e-11 Melanoma; CRC cis rs12936587 0.692 rs35660942 chr17:17527185 G/A cg24612305 chr17:17875800 TOM1L2;LRRC48 -0.42 -5.72 -0.3 2.44e-8 Hip circumference;Coronary artery disease or large artery stroke;Coronary heart disease;Coronary artery disease; CRC cis rs875971 0.505 rs2462573 chr7:65507392 C/T cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.51 -7.72 -0.39 1.38e-13 Aortic root size; CRC cis rs7223966 1.000 rs11542436 chr17:61778689 A/C cg05941027 chr17:61774174 LIMD2 0.37 6.75 0.35 6.81e-11 Hip circumference adjusted for BMI;Body mass index; CRC cis rs6879260 1.000 rs7725605 chr5:179732678 T/G cg02891314 chr5:179741120 GFPT2 -0.71 -11.29 -0.53 3.44e-25 Height; CRC cis rs823143 0.570 rs1361754 chr1:205801872 C/T cg14893161 chr1:205819251 PM20D1 -0.68 -11.12 -0.52 1.32e-24 Monocyte percentage of white cells; CRC cis rs2412459 1.000 rs6492925 chr15:40304170 T/G cg16127683 chr15:40268777 EIF2AK4 -0.68 -6.39 -0.33 5.69e-10 Response to haloperidol in psychosis; CRC cis rs2836974 0.644 rs9978775 chr21:40694526 A/G cg22974920 chr21:40686053 BRWD1 -0.43 -5.85 -0.31 1.2e-8 Cognitive function; CRC cis rs8060686 0.565 rs4359427 chr16:68202747 C/T cg26727032 chr16:67993705 SLC12A4 -0.56 -7.48 -0.38 6.89e-13 HDL cholesterol;Metabolic syndrome; CRC cis rs6502050 0.731 rs4789730 chr17:80145983 T/A cg25804541 chr17:80189381 SLC16A3 -0.3 -5.73 -0.3 2.28e-8 Life satisfaction; CRC cis rs28386778 0.897 rs2028567 chr17:61915326 G/A cg25654072 chr17:61904446 PSMC5;FTSJ3 0.74 11.42 0.53 1.12e-25 Prudent dietary pattern; CRC cis rs7772486 0.875 rs6909827 chr6:146365738 A/G cg23711669 chr6:146136114 FBXO30 0.62 10.57 0.5 1.09e-22 Lobe attachment (rater-scored or self-reported); CRC cis rs1552244 0.554 rs34391585 chr3:9999208 G/C cg18598329 chr3:10140678 FANCD2;C3orf24 -0.52 -7.53 -0.38 5.05e-13 Alzheimer's disease; CRC cis rs6952808 0.609 rs6950151 chr7:1953521 T/C cg14004847 chr7:1930337 MAD1L1 -0.41 -6.14 -0.32 2.34e-9 Bipolar disorder and schizophrenia; CRC cis rs2857891 1.000 rs2857891 chr11:6962957 C/T cg22096450 chr11:6947773 ZNF215 0.61 6.43 0.33 4.36e-10 Response to cytadine analogues (cytosine arabinoside); CRC cis rs2294693 0.891 rs1072119 chr6:40993072 G/A cg14769373 chr6:40998127 UNC5CL -0.54 -7.06 -0.36 1.02e-11 Gastric cancer;Non-cardia gastric cancer; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg06441946 chr5:145583671 RBM27 0.49 6.43 0.33 4.37e-10 Thyroid stimulating hormone; CRC cis rs826838 0.967 rs1719852 chr12:39128531 A/G cg13010199 chr12:38710504 ALG10B -0.41 -5.86 -0.31 1.11e-8 Heart rate; CRC cis rs2717559 0.542 rs10956986 chr8:143886601 C/T cg22687807 chr8:143858763 LYNX1 -0.73 -13.91 -0.61 6.6e-35 Urinary tract infection frequency; CRC cis rs1448094 0.580 rs11615323 chr12:86282171 T/C cg02569458 chr12:86230093 RASSF9 0.47 7.51 0.38 5.48e-13 Major depressive disorder; CRC cis rs10504229 0.679 rs10504217 chr8:58037522 A/G cg02725872 chr8:58115012 NA -0.35 -5.99 -0.31 5.5e-9 Developmental language disorder (linguistic errors); CRC cis rs12476592 0.602 rs1348806 chr2:63895884 A/T cg10828910 chr2:63850056 LOC388955 0.51 6.44 0.33 4.22e-10 Childhood ear infection; CRC cis rs35110281 0.748 rs1584918 chr21:45042419 C/T cg01579765 chr21:45077557 HSF2BP -0.38 -7.31 -0.37 2.04e-12 Mean corpuscular volume; CRC cis rs6570726 0.935 rs367612 chr6:145828987 A/G cg23711669 chr6:146136114 FBXO30 0.69 12.05 0.55 6.08e-28 Lobe attachment (rater-scored or self-reported); CRC cis rs1059312 0.545 rs7312683 chr12:129280105 T/C cg21616243 chr12:129299702 MGC16384;SLC15A4 -0.51 -7.37 -0.38 1.41e-12 Systemic lupus erythematosus; CRC cis rs4443100 0.670 rs9608071 chr22:23408118 G/T cg14186256 chr22:23484241 RTDR1 0.51 6.5 0.34 2.99e-10 Serum parathyroid hormone levels; CRC cis rs4713118 0.869 rs10214440 chr6:27702440 A/C cg15845792 chr6:28175446 NA 0.66 9.05 0.45 1.24e-17 Parkinson's disease; CRC cis rs17818399 0.788 rs17818315 chr2:46818992 C/T cg26688816 chr2:46740690 ATP6V1E2 -0.49 -6.57 -0.34 1.97e-10 Height; CRC cis rs2228479 0.764 rs7184960 chr16:89961661 C/T cg04013166 chr16:89971882 TCF25 0.57 6.4 0.33 5.49e-10 Skin colour saturation; CRC trans rs6601327 0.736 rs4840426 chr8:9408978 G/T cg06636001 chr8:8085503 FLJ10661 0.45 6.85 0.35 3.63e-11 Multiple myeloma (hyperdiploidy); CRC cis rs6424115 0.708 rs12755062 chr1:24185025 T/A cg08896387 chr1:24191740 FUCA1 0.53 6.94 0.36 2.12e-11 Immature fraction of reticulocytes; CRC cis rs9925964 0.900 rs56813533 chr16:31070481 A/T cg03418659 chr16:31128414 MYST1 0.47 6.75 0.35 6.57e-11 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs365302 1.000 rs401578 chr6:159645783 A/G cg14500486 chr6:159655392 FNDC1 0.43 6.59 0.34 1.76e-10 Coronary heart disease; CRC cis rs8103278 0.507 rs4802275 chr19:46260375 C/T cg20908204 chr19:46285434 DMPK 0.34 7.41 0.38 1.05e-12 Coronary artery disease; CRC trans rs79976124 0.837 rs12201218 chr6:66653619 C/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.75 -9.41 -0.46 8.93e-19 Type 2 diabetes; CRC cis rs6831352 0.918 rs1126672 chr4:100047812 G/A cg13256891 chr4:100009986 ADH5 -0.66 -8.89 -0.44 4.04e-17 Alcohol dependence; CRC cis rs4638749 0.677 rs6757761 chr2:108834842 T/C cg25838818 chr2:108905173 SULT1C2 -0.34 -5.75 -0.3 2.01e-8 Blood pressure; CRC trans rs747782 0.528 rs11039674 chr11:48336116 C/T cg15704280 chr7:45808275 SEPT13 0.68 6.52 0.34 2.58e-10 Intraocular pressure; CRC cis rs1577917 1.000 rs7771342 chr6:86631936 C/A cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.52 -6.78 -0.35 5.63e-11 Response to antipsychotic treatment; CRC cis rs7937682 0.883 rs1789358 chr11:111474116 G/A cg19812747 chr11:111475976 SIK2 -0.58 -9.93 -0.48 1.68e-20 Primary sclerosing cholangitis; CRC cis rs881375 0.715 rs10818482 chr9:123648085 C/T cg09586646 chr9:123605570 PSMD5;LOC253039 -0.4 -5.71 -0.3 2.52e-8 Rheumatoid arthritis; CRC cis rs9858542 0.953 rs3811699 chr3:49396360 T/C cg00383909 chr3:49044727 WDR6 0.43 5.65 0.3 3.45e-8 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs9341808 0.718 rs9448908 chr6:80898069 C/T cg08355045 chr6:80787529 NA 0.43 7.04 0.36 1.12e-11 Sitting height ratio; CRC cis rs7208859 0.623 rs9898084 chr17:29082334 C/G cg01831904 chr17:28903510 LRRC37B2 -0.62 -6.5 -0.34 2.97e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs9399135 0.967 rs2297338 chr6:135375762 G/A cg22676075 chr6:135203613 NA 0.4 6.11 0.32 2.85e-9 Red blood cell count; CRC cis rs875971 0.862 rs11773628 chr7:65982631 G/T cg18252515 chr7:66147081 NA 0.43 6.27 0.33 1.14e-9 Aortic root size; CRC cis rs6570726 0.791 rs6570692 chr6:145904401 T/A cg23711669 chr6:146136114 FBXO30 0.68 11.35 0.53 2.09e-25 Lobe attachment (rater-scored or self-reported); CRC cis rs1552244 0.554 rs6762594 chr3:9995516 G/A cg00166722 chr3:10149974 C3orf24 0.42 6.3 0.33 9.75e-10 Alzheimer's disease; CRC cis rs11212617 1.000 rs227088 chr11:108243755 C/T cg12106634 chr11:108092400 ATM;NPAT 0.44 6.55 0.34 2.19e-10 Response to metformin in type 2 diabetes (glycemic); CRC cis rs8060686 0.516 rs8059575 chr16:68272635 C/G cg26727032 chr16:67993705 SLC12A4 -0.64 -9.56 -0.47 2.9e-19 HDL cholesterol;Metabolic syndrome; CRC cis rs8044995 0.925 rs9928653 chr16:68252079 T/C cg09835421 chr16:68378352 PRMT7 -0.44 -5.69 -0.3 2.78e-8 Schizophrenia; CRC cis rs7833986 0.501 rs72653941 chr8:56942247 T/C cg23139584 chr8:56987506 RPS20;SNORD54 0.83 11.68 0.54 1.36e-26 Height; CRC cis rs6714710 0.603 rs17489984 chr2:98421364 A/G cg26665480 chr2:98280029 ACTR1B 0.53 7.27 0.37 2.59e-12 Posterior cortical atrophy and Alzheimer's disease; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg13561157 chr9:139922545 C9orf139;ABCA2 0.44 6.12 0.32 2.65e-9 Response to antipsychotic treatment; CRC cis rs929354 1.000 rs1182410 chr7:157063837 C/T cg16102536 chr7:156981717 UBE3C -0.39 -6.52 -0.34 2.72e-10 Body mass index; CRC cis rs7224685 0.530 rs7221574 chr17:4007543 T/C cg09695851 chr17:3907499 NA 0.49 6.19 0.32 1.76e-9 Type 2 diabetes; CRC cis rs977987 0.836 rs34673655 chr16:75323559 T/C cg03315344 chr16:75512273 CHST6 0.54 8.95 0.44 2.67e-17 Dupuytren's disease; CRC cis rs1008375 0.966 rs2010053 chr4:17583806 A/C cg16339924 chr4:17578868 LAP3 0.6 7.98 0.4 2.42e-14 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs9287719 0.601 rs9287718 chr2:10701629 A/T cg00105475 chr2:10696890 NA -0.47 -7.27 -0.37 2.6e-12 Prostate cancer; CRC cis rs4363385 0.818 rs11205174 chr1:153001230 C/T cg25856811 chr1:152973957 SPRR3 0.25 7.06 0.36 1.01e-11 Inflammatory skin disease; CRC cis rs9914988 0.943 rs4794838 chr17:27131095 T/C cg12682573 chr17:27188876 MIR451;MIR144 0.58 7.99 0.4 2.37e-14 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs10504229 0.906 rs56130194 chr8:58197061 C/A cg11062466 chr8:58055876 NA 0.45 5.6 0.3 4.45e-8 Developmental language disorder (linguistic errors); CRC cis rs2732480 0.557 rs2634682 chr12:48732943 T/C cg24011408 chr12:48396354 COL2A1 0.45 6.08 0.32 3.24e-9 Hemoglobin concentration;Red blood cell count;Hematocrit; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg20646317 chr12:50794494 LARP4 0.45 6.25 0.33 1.29e-9 Response to antipsychotic treatment; CRC cis rs6831352 0.840 rs17817868 chr4:100060623 C/T cg13256891 chr4:100009986 ADH5 -0.66 -8.98 -0.44 2.17e-17 Alcohol dependence; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg27060912 chr19:6517005 NA 0.47 7.4 0.38 1.14e-12 Liver disease severity in Alagille syndrome; CRC cis rs8067545 0.611 rs2703814 chr17:20117151 T/C cg13482628 chr17:19912719 NA -0.47 -7.35 -0.38 1.56e-12 Schizophrenia; CRC cis rs79349575 0.749 rs8182364 chr17:47018025 A/G cg22482690 chr17:47019901 SNF8 0.48 8.01 0.4 2.01e-14 Type 2 diabetes; CRC cis rs7666738 0.830 rs17550610 chr4:99008273 T/C cg17366294 chr4:99064904 C4orf37 0.44 7.39 0.38 1.19e-12 Colonoscopy-negative controls vs population controls; CRC trans rs208520 0.754 rs851592 chr6:66875175 G/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.02 -14.02 -0.61 2.54e-35 Exhaled nitric oxide output; CRC cis rs17767392 0.958 rs2877729 chr14:71887868 G/A cg13720639 chr14:72061746 SIPA1L1 -0.55 -6.95 -0.36 1.96e-11 Mitral valve prolapse; CRC cis rs847577 0.609 rs17435847 chr7:97792820 G/A cg00277769 chr7:97922759 BAIAP2L1 -0.4 -6.63 -0.34 1.42e-10 Breast cancer; CRC cis rs6500602 0.702 rs17761816 chr16:4548832 C/G cg08645402 chr16:4508243 NA 0.64 11.48 0.53 6.92e-26 Schizophrenia; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg26872475 chr11:119039430 NLRX1 0.5 7.23 0.37 3.48e-12 Response to antipsychotic treatment; CRC cis rs4268898 0.529 rs4426488 chr2:24372815 A/G cg06627628 chr2:24431161 ITSN2 0.46 6.9 0.36 2.68e-11 Asthma; CRC cis rs7584330 0.657 rs7599658 chr2:238352898 A/C cg16989719 chr2:238392110 NA 0.48 8.74 0.43 1.23e-16 Prostate cancer; CRC cis rs4713118 0.955 rs9468200 chr6:27683063 T/A cg26587870 chr6:27730563 NA -0.42 -6.22 -0.32 1.54e-9 Parkinson's disease; CRC cis rs9926296 0.744 rs6860 chr16:89711120 C/T cg01097406 chr16:89675127 NA 0.52 9.44 0.46 6.87e-19 Vitiligo; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg11875500 chr19:36391588 NFKBID 0.41 6.22 0.32 1.54e-9 Intelligence (multi-trait analysis); CRC cis rs1395 0.778 rs2078616 chr2:27441904 A/G cg14242246 chr2:27434262 C2orf28;SLC5A6 0.42 7.89 0.4 4.59e-14 Blood metabolite levels; CRC cis rs10504229 1.000 rs112284078 chr8:58191640 A/G cg05313129 chr8:58192883 C8orf71 -0.45 -6.56 -0.34 2.08e-10 Developmental language disorder (linguistic errors); CRC trans rs7395662 1.000 rs6485875 chr11:48581034 T/C cg21153622 chr11:89784906 NA -0.46 -7.35 -0.38 1.54e-12 HDL cholesterol; CRC cis rs727505 0.564 rs56068095 chr7:124831906 A/T cg23710748 chr7:124431027 NA -0.62 -10.33 -0.49 7.81e-22 Lewy body disease; CRC cis rs6964587 0.839 rs12536702 chr7:91471576 G/C cg17063962 chr7:91808500 NA 0.72 11.66 0.54 1.57e-26 Breast cancer; CRC cis rs501120 0.564 rs11238905 chr10:44685136 T/A cg09554077 chr10:44749378 NA 0.55 7.67 0.39 1.95e-13 Coronary artery disease;Coronary heart disease; CRC trans rs10411161 0.702 rs8113685 chr19:52383890 C/T cg22319618 chr22:45562946 NUP50 -0.68 -7.53 -0.38 4.85e-13 Breast cancer; CRC cis rs1153858 1.000 rs7494956 chr15:45668565 T/C cg21132104 chr15:45694354 SPATA5L1 0.57 8.29 0.42 2.85e-15 Homoarginine levels; CRC cis rs875971 1.000 rs6963646 chr7:65685767 T/C cg12463550 chr7:65579703 CRCP -0.49 -7.14 -0.37 6.07e-12 Aortic root size; CRC cis rs17067123 0.539 rs79352031 chr4:180066810 C/T cg26610307 chr4:180072759 NA -0.56 -6.74 -0.35 7.28e-11 Response to hepatitis C treatment; CRC cis rs11122272 0.735 rs2066140 chr1:231504311 C/G cg06096015 chr1:231504339 EGLN1 0.39 5.93 0.31 7.57e-9 Hemoglobin concentration; CRC cis rs6545883 0.859 rs13004855 chr2:61505072 C/T cg15711740 chr2:61764176 XPO1 0.43 5.61 0.3 4.27e-8 Tuberculosis; CRC cis rs2108622 0.727 rs7251296 chr19:15983736 A/G cg13772218 chr19:15982569 NA 0.46 6.55 0.34 2.23e-10 Circulating phylloquinone levels;Vitamin E levels;Acenocoumarol maintenance dosage;Response to Vitamin E supplementation;Metabolite levels;Warfarin maintenance dose; CRC cis rs637571 0.522 rs556643 chr11:65733289 C/T cg17985854 chr11:65770987 BANF1;EIF1AD 0.45 7.48 0.38 6.76e-13 Eosinophil percentage of white cells; CRC cis rs1862618 0.671 rs173763 chr5:56225418 G/A cg18230493 chr5:56204884 C5orf35 -0.59 -8.63 -0.43 2.72e-16 Initial pursuit acceleration; CRC cis rs600806 0.888 rs12046539 chr1:109875415 C/T cg23032129 chr1:109941072 SORT1 -0.27 -5.73 -0.3 2.21e-8 Intelligence (multi-trait analysis); CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg19889307 chr10:75911429 ADK;AP3M1 -0.41 -6.3 -0.33 9.42e-10 Myopia (pathological); CRC cis rs3087591 0.708 rs4794887 chr17:29649696 G/A cg24425628 chr17:29625626 OMG;NF1 0.71 13.05 0.58 1.15e-31 Hip circumference; CRC cis rs10771431 0.935 rs1988852 chr12:9372862 G/A cg22349387 chr12:9600060 DDX12 -0.36 -5.72 -0.3 2.39e-8 Breast size; CRC cis rs34779708 0.966 rs34605125 chr10:35411246 A/G cg03585969 chr10:35415529 CREM 0.65 8.64 0.43 2.56e-16 Inflammatory bowel disease;Crohn's disease; CRC cis rs10504229 0.679 rs72649119 chr8:58040301 T/C cg02725872 chr8:58115012 NA -0.36 -6.04 -0.32 4.18e-9 Developmental language disorder (linguistic errors); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg08744727 chr4:206112 ZNF876P -0.39 -6.42 -0.33 4.64e-10 Liver disease severity in Alagille syndrome; CRC cis rs6502050 0.835 rs35555954 chr17:80122438 T/C cg02741985 chr17:80059408 CCDC57 0.43 6.97 0.36 1.71e-11 Life satisfaction; CRC cis rs1577917 0.958 rs12202188 chr6:86562700 C/A cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.51 -6.59 -0.34 1.76e-10 Response to antipsychotic treatment; CRC cis rs9926296 0.508 rs1558184 chr16:89842374 T/G cg04287289 chr16:89883240 FANCA 0.84 15.28 0.64 3.3e-40 Vitiligo; CRC cis rs4718428 0.705 rs4717328 chr7:66352665 T/C cg18252515 chr7:66147081 NA -0.54 -7.63 -0.39 2.58e-13 Corneal structure; CRC cis rs77861329 0.670 rs9828327 chr3:52120209 T/C cg08692210 chr3:52188851 WDR51A 0.53 6.01 0.31 4.85e-9 Macrophage inflammatory protein 1b levels; CRC cis rs12188164 0.686 rs72711370 chr5:421057 A/C cg00976097 chr5:421733 AHRR -0.45 -6.02 -0.31 4.76e-9 Cystic fibrosis severity; CRC cis rs10791097 0.608 rs12363140 chr11:130744268 A/C cg12179176 chr11:130786555 SNX19 0.75 12.66 0.57 3.28e-30 Autism spectrum disorder or schizophrenia;Schizophrenia; CRC trans rs2303319 0.504 rs62189051 chr2:162622318 G/A cg22902534 chr3:183892754 AP2M1 -0.7 -6.07 -0.32 3.56e-9 Cognitive function; CRC cis rs6952808 0.573 rs12668848 chr7:2020995 G/A cg02951883 chr7:2050386 MAD1L1 -0.63 -10.43 -0.5 3.3e-22 Bipolar disorder and schizophrenia; CRC cis rs35306767 0.953 rs12354639 chr10:963681 G/A cg26597838 chr10:835615 NA 0.82 10.3 0.49 9.84e-22 Eosinophil percentage of granulocytes; CRC cis rs3008870 0.755 rs2755242 chr1:67479598 T/C cg08660285 chr1:67390436 MIER1;WDR78 0.56 7.93 0.4 3.43e-14 Lymphocyte percentage of white cells; CRC cis rs11190604 1.000 rs10883503 chr10:102275504 C/A cg16342193 chr10:102329863 NA -0.37 -6.11 -0.32 2.8e-9 Palmitoleic acid (16:1n-7) levels; CRC cis rs10489202 0.608 rs7533646 chr1:168077593 A/C cg24449463 chr1:168025552 DCAF6 -0.52 -7.3 -0.37 2.21e-12 Schizophrenia; CRC cis rs1862618 0.671 rs2591957 chr5:56243146 A/T cg20203395 chr5:56204925 C5orf35 0.57 7.85 0.4 5.99e-14 Initial pursuit acceleration; CRC cis rs12928939 0.517 rs12149325 chr16:71968147 G/C cg03805757 chr16:71968109 PKD1L3 -0.6 -7.97 -0.4 2.63e-14 Post bronchodilator FEV1; CRC cis rs798554 0.757 rs2533882 chr7:2846894 G/T cg04166393 chr7:2884313 GNA12 0.54 7.24 0.37 3.29e-12 Height; CRC cis rs41271473 0.526 rs10916337 chr1:228714902 C/T cg16512390 chr1:228756714 NA 0.64 6.7 0.35 8.82e-11 Chronic lymphocytic leukemia; CRC cis rs4481887 0.504 rs11204608 chr1:248360379 C/T cg00666640 chr1:248458726 OR2T12 0.44 7.07 0.36 9.39e-12 Common traits (Other); CRC trans rs855408 0.959 rs526759 chr6:62897695 G/A cg21737066 chr3:72495901 RYBP 0.49 5.96 0.31 6.43e-9 Epstein-Barr virus copy number in lymphoblastoid cell lines; CRC cis rs13256369 0.802 rs11249883 chr8:8561537 G/A cg00074818 chr8:8560427 CLDN23 0.41 7.36 0.38 1.45e-12 Obesity-related traits; CRC cis rs4604732 0.631 rs1106719 chr1:247624713 A/G cg12754571 chr1:247694271 LOC148824;OR2C3 -0.42 -5.86 -0.31 1.12e-8 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg14122300 chr14:69446504 ACTN1 -0.49 -6.24 -0.33 1.34e-9 Diisocyanate-induced asthma; CRC cis rs2062225 0.877 rs4849340 chr2:111774116 G/A cg11729679 chr2:111877065 BCL2L11 -0.56 -5.62 -0.3 4.08e-8 Monocyte count; CRC cis rs2832191 0.647 rs11170 chr21:30378090 C/T cg24692254 chr21:30365293 RNF160 0.84 15.48 0.65 5.55e-41 Dental caries; CRC cis rs713477 0.654 rs12886848 chr14:55911138 G/A cg13175173 chr14:55914753 NA -0.43 -7.48 -0.38 7e-13 Pediatric bone mineral content (femoral neck); CRC trans rs10504229 1.000 rs66477954 chr8:58187810 C/T cg04077850 chr5:125800366 GRAMD3 0.37 6.27 0.33 1.15e-9 Developmental language disorder (linguistic errors); CRC cis rs6908034 0.607 rs73376680 chr6:19808099 G/A cg02682789 chr6:19804855 NA 0.78 6.83 0.35 4.16e-11 Endometriosis;Deep ovarian and/or rectovaginal disease with dense adhesions; CRC cis rs9467711 0.516 rs523383 chr6:25869848 A/G cg08501292 chr6:25962987 TRIM38 0.58 6.48 0.34 3.36e-10 Autism spectrum disorder or schizophrenia; CRC cis rs3785574 0.924 rs2584641 chr17:61862889 A/G cg22520471 chr17:61851767 DDX42;CCDC47 0.46 6.49 0.34 3.25e-10 Height; CRC cis rs2050392 0.687 rs608693 chr10:30734971 G/A cg18806716 chr10:30721971 MAP3K8 -0.55 -8.2 -0.41 5.4e-15 Inflammatory bowel disease; CRC cis rs10504229 0.683 rs59679713 chr8:58134370 G/C cg02290350 chr8:58132656 NA -0.57 -8.08 -0.41 1.22e-14 Developmental language disorder (linguistic errors); CRC cis rs6724607 0.875 rs9630991 chr2:191432139 G/A cg10560079 chr2:191398806 TMEM194B 0.46 6.42 0.33 4.79e-10 Pulse pressure; CRC trans rs11165623 0.792 rs13375510 chr1:96920723 A/G cg10631902 chr5:14652156 NA -0.51 -9.58 -0.47 2.51e-19 Hip circumference;Waist circumference; CRC cis rs13108904 0.901 rs6826029 chr4:1307689 A/G cg19318889 chr4:1322082 MAEA 0.41 6.24 0.33 1.33e-9 Obesity-related traits; CRC cis rs12745968 0.589 rs10782936 chr1:93041906 A/G cg17283838 chr1:93427260 FAM69A -0.43 -6.0 -0.31 5.14e-9 Bipolar disorder and schizophrenia; CRC cis rs9911578 0.835 rs1476596 chr17:56485358 C/T cg05425664 chr17:57184151 TRIM37 -0.45 -6.96 -0.36 1.8e-11 Intelligence (multi-trait analysis); CRC cis rs12701220 0.655 rs34344742 chr7:1149288 C/G cg26769984 chr7:1090371 C7orf50 0.56 7.66 0.39 2.16e-13 Bronchopulmonary dysplasia; CRC cis rs6679356 0.789 rs4655698 chr1:67798327 T/G cg24364144 chr1:67875067 SERBP1 0.41 5.81 0.3 1.5e-8 Primary biliary cholangitis; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg05970768 chr5:171682616 UBTD2 -0.41 -6.36 -0.33 6.77e-10 Liver disease severity in Alagille syndrome; CRC cis rs9457247 0.756 rs1811123 chr6:167403443 T/C cg23791538 chr6:167370224 RNASET2 -0.39 -6.07 -0.32 3.52e-9 Crohn's disease; CRC cis rs1577917 0.740 rs7752502 chr6:86410651 C/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A 0.61 8.61 0.43 2.98e-16 Response to antipsychotic treatment; CRC cis rs6547741 0.967 rs4665996 chr2:27814343 T/C cg27432699 chr2:27873401 GPN1 0.77 13.64 0.6 7.11e-34 Oral cavity cancer; CRC cis rs7208859 0.573 rs11656278 chr17:29075188 C/T cg13385521 chr17:29058706 SUZ12P 0.72 8.17 0.41 6.77e-15 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs9393692 0.905 rs9379838 chr6:26277133 C/T cg13736514 chr6:26305472 NA -0.61 -11.45 -0.53 8.96e-26 Educational attainment; CRC cis rs477895 0.653 rs7102327 chr11:63908720 C/T cg19465662 chr11:63993652 NUDT22;TRPT1 0.71 8.87 0.44 4.84e-17 Mean platelet volume; CRC cis rs17253792 0.545 rs12893061 chr14:56016097 A/T cg01858014 chr14:56050164 KTN1 -0.89 -6.86 -0.35 3.42e-11 Putamen volume; CRC cis rs7945705 0.747 rs2742480 chr11:8993130 A/G cg00186954 chr11:8933980 ST5;C11orf17 -0.46 -7.72 -0.39 1.4e-13 Hemoglobin concentration; CRC cis rs7553864 0.835 rs4415539 chr1:87604245 C/T cg02083836 chr1:87617350 LOC339524 -0.35 -6.28 -0.33 1.07e-9 Smoking behavior; CRC cis rs708547 0.830 rs1713983 chr4:57883084 A/G cg25525207 chr4:57843836 C4orf14;POLR2B -0.49 -6.26 -0.33 1.21e-9 Response to bleomycin (chromatid breaks); CRC trans rs11722228 0.549 rs3796818 chr4:10097976 C/T cg26043149 chr18:55253948 FECH 1.13 17.37 0.69 1.99e-48 Gout;Urate levels;Serum uric acid levels; CRC trans rs7618501 0.633 rs4688755 chr3:50064424 G/A cg21665057 chr3:196295764 WDR53;FBXO45 -0.61 -9.71 -0.47 8.9e-20 Intelligence (multi-trait analysis); CRC cis rs265548 0.646 rs36692 chr19:17906839 C/T cg21960279 chr19:17905606 B3GNT3 0.48 7.63 0.39 2.53e-13 Tumor biomarkers; CRC cis rs1552244 1.000 rs3895942 chr3:10108745 G/C cg00166722 chr3:10149974 C3orf24 0.66 9.02 0.45 1.59e-17 Alzheimer's disease; CRC cis rs1448094 0.549 rs57614821 chr12:86235361 A/C cg19622623 chr12:86230825 RASSF9 -0.41 -6.5 -0.34 2.99e-10 Major depressive disorder; CRC trans rs8005962 0.724 rs28589908 chr14:96105511 C/T cg21678461 chr11:20180700 DBX1 0.31 6.2 0.32 1.65e-9 Tuberculosis; CRC cis rs9303401 0.646 rs8067682 chr17:57219391 A/G cg02118635 chr17:56770003 RAD51C;TEX14 0.43 6.59 0.34 1.77e-10 Cognitive test performance; CRC cis rs11711311 0.955 rs10934247 chr3:113534941 T/C cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.51 -6.93 -0.36 2.23e-11 IgG glycosylation; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg10512748 chr1:28844557 SNHG3-RCC1;RCC1 0.53 7.48 0.38 6.88e-13 Response to antipsychotic treatment; CRC cis rs2857891 0.909 rs56372435 chr11:6938658 T/C cg17084751 chr11:6953558 ZNF215 -0.51 -5.81 -0.31 1.47e-8 Response to cytadine analogues (cytosine arabinoside); CRC trans rs1814175 0.754 rs7103235 chr11:49699191 A/G cg03929089 chr4:120376271 NA -0.82 -12.79 -0.58 1.11e-30 Height; CRC cis rs7705042 0.865 rs249643 chr5:141524746 C/G cg07392085 chr5:141489673 NDFIP1 0.45 7.25 0.37 2.94e-12 Asthma; CRC cis rs736801 0.808 rs6866614 chr5:131787137 A/G cg02033258 chr5:131593261 PDLIM4 -0.33 -5.79 -0.3 1.68e-8 Breast cancer;Mosquito bite size; CRC trans rs4263408 0.934 rs9683743 chr4:39703194 A/C cg08307039 chr5:64920116 TRIM23;C5orf44 -0.41 -6.0 -0.31 5.28e-9 Plasma amyloid beta peptide concentrations (ABx-40); CRC cis rs9487051 0.836 rs9400270 chr6:109607488 G/A cg01475377 chr6:109611718 NA -0.49 -9.29 -0.46 2.13e-18 Reticulocyte fraction of red cells; CRC cis rs12618769 0.597 rs3754892 chr2:99063318 T/A cg18455616 chr2:99124870 INPP4A 0.37 5.73 0.3 2.26e-8 Bipolar disorder; CRC trans rs6550704 0.687 rs9865314 chr3:22634337 A/G cg11814422 chr18:47018265 SNORD58A;RPL17;SNORD58B -0.41 -6.29 -0.33 9.87e-10 Daytime sleep phenotypes; CRC cis rs2832077 0.527 rs2776210 chr21:30268558 A/G cg24692254 chr21:30365293 RNF160 0.49 7.19 0.37 4.34e-12 Cognitive test performance; CRC cis rs60843830 1.000 rs6709534 chr2:217334 G/C cg00108164 chr2:264199 ACP1;SH3YL1 0.63 9.8 0.48 4.59e-20 Spherical equivalent (joint analysis main effects and education interaction); CRC cis rs7605378 0.528 rs281780 chr2:200756331 G/C cg17644776 chr2:200775616 C2orf69 0.49 7.93 0.4 3.46e-14 Osteoporosis; CRC cis rs1448094 0.781 rs7959093 chr12:86335502 C/A cg02569458 chr12:86230093 RASSF9 0.47 7.83 0.4 6.86e-14 Major depressive disorder; CRC cis rs875971 1.000 rs709597 chr7:65825983 A/G cg00343986 chr7:65444356 GUSB -0.46 -6.81 -0.35 4.73e-11 Aortic root size; CRC cis rs6988636 1.000 rs60827294 chr8:124187842 T/C cg27053337 chr8:124217698 FAM83A 0.45 6.82 0.35 4.48e-11 Urinary uromodulin levels; CRC cis rs34779708 0.966 rs2045918 chr10:35418517 T/G cg03585969 chr10:35415529 CREM 0.66 8.68 0.43 1.88e-16 Inflammatory bowel disease;Crohn's disease; CRC cis rs68170813 0.559 rs10487271 chr7:106898458 T/C cg02696742 chr7:106810147 HBP1 -0.6 -6.65 -0.34 1.25e-10 Coronary artery disease; CRC cis rs35883536 1.000 rs12239531 chr1:101085661 A/G cg14515779 chr1:101123966 NA -0.45 -8.46 -0.42 9.07e-16 Monocyte count; CRC cis rs9903692 0.954 rs875066 chr17:46139732 T/G cg21215337 chr17:46176117 CBX1 0.42 7.67 0.39 1.99e-13 Pulse pressure; CRC cis rs10540 1.000 rs67912009 chr11:495057 G/T cg15790184 chr11:494944 RNH1 0.62 6.92 0.36 2.36e-11 Body mass index; CRC cis rs9361491 0.580 rs13204088 chr6:79757438 A/C cg05283184 chr6:79620031 NA -0.45 -6.46 -0.34 3.7e-10 Intelligence (multi-trait analysis); CRC cis rs13191362 0.935 rs35537826 chr6:163145867 G/A cg21926612 chr6:163149169 PACRG;PARK2 0.83 11.94 0.55 1.55e-27 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs6942756 1.000 rs67820265 chr7:128887925 A/G cg02491457 chr7:128862824 NA -0.75 -9.92 -0.48 1.77e-20 White matter hyperintensity burden; CRC cis rs17253792 0.822 rs17832371 chr14:56162302 C/A cg01858014 chr14:56050164 KTN1 -0.88 -7.09 -0.36 8.17e-12 Putamen volume; CRC cis rs611744 0.647 rs589347 chr8:109253929 T/A cg21045802 chr8:109455806 TTC35 0.42 6.65 0.34 1.24e-10 Dupuytren's disease; CRC cis rs853679 0.517 rs3173443 chr6:28137027 T/G cg02683197 chr6:28174875 NA 0.87 10.73 0.51 3.25e-23 Depression; CRC cis rs9733 0.519 rs72704603 chr1:150707992 C/T cg15448220 chr1:150897856 SETDB1 0.49 7.01 0.36 1.35e-11 Tonsillectomy; CRC cis rs2880765 0.835 rs7174323 chr15:86049719 A/C cg17133734 chr15:86042851 AKAP13 0.42 6.78 0.35 5.62e-11 Coronary artery disease; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg05315670 chr11:64037304 BAD 0.42 6.7 0.35 9.27e-11 Liver disease severity in Alagille syndrome; CRC cis rs9322193 0.962 rs9688809 chr6:150109056 C/T cg07701084 chr6:150067640 NUP43 0.47 6.61 0.34 1.51e-10 Lung cancer; CRC cis rs875971 1.000 rs12532998 chr7:65967459 A/C cg12463550 chr7:65579703 CRCP 0.47 6.81 0.35 4.69e-11 Aortic root size; CRC cis rs6933660 0.646 rs9397410 chr6:151770503 C/T cg14262678 chr6:151773367 RMND1;C6orf211 0.6 10.09 0.49 4.82e-21 Menarche (age at onset); CRC cis rs2880765 0.835 rs4340287 chr15:86043737 A/G cg17133734 chr15:86042851 AKAP13 0.43 6.82 0.35 4.43e-11 Coronary artery disease; CRC trans rs10506458 0.915 rs998506 chr12:63400017 C/T cg22491629 chr6:157744540 C6orf35 -0.77 -9.18 -0.45 4.96e-18 Hemostatic factors and hematological phenotypes; CRC cis rs6951245 0.529 rs76001997 chr7:1152615 C/T cg03188948 chr7:1209495 NA 0.53 6.32 0.33 8.44e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs4988958 0.565 rs10206291 chr2:103038863 T/C cg03938978 chr2:103052716 IL18RAP 0.59 10.13 0.49 3.5e-21 Asthma (childhood onset); CRC cis rs6504622 0.755 rs7219544 chr17:45166928 G/T cg16759221 chr17:45003025 GOSR2 0.42 6.69 0.35 9.76e-11 Orofacial clefts; CRC cis rs10242455 0.702 rs41385645 chr7:98974038 A/T cg18809830 chr7:99032528 PTCD1 -0.81 -6.2 -0.32 1.67e-9 Blood metabolite levels; CRC cis rs9921222 0.521 rs78867928 chr16:368986 C/T cg08923669 chr16:420230 MRPL28 -0.59 -7.6 -0.39 3.02e-13 Bone mineral density (spine);Bone mineral density; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg13476105 chr17:7819425 LOC284023 0.45 6.36 0.33 6.86e-10 Response to antipsychotic treatment; CRC cis rs10504229 0.500 rs9772760 chr8:57986999 G/C cg02725872 chr8:58115012 NA -0.32 -5.72 -0.3 2.39e-8 Developmental language disorder (linguistic errors); CRC cis rs11690935 0.549 rs796839 chr2:172916214 A/C cg13550731 chr2:172543902 DYNC1I2 0.61 8.99 0.44 1.99e-17 Schizophrenia; CRC cis rs2976388 0.609 rs2717601 chr8:143807924 T/C cg04969067 chr8:143858791 LYNX1 0.45 7.59 0.39 3.34e-13 Urinary tract infection frequency; CRC cis rs62244186 0.659 rs1806579 chr3:44509281 T/C cg18165381 chr3:44552316 NA -0.39 -5.86 -0.31 1.1e-8 Depressive symptoms; CRC cis rs7089973 0.585 rs7907837 chr10:116610690 G/T cg23260525 chr10:116636907 FAM160B1 0.39 9.26 0.45 2.7e-18 Bipolar disorder or attention deficit hyperactivity disorder; CRC cis rs12926788 0.640 rs12924246 chr16:24844629 A/G cg00339695 chr16:24857497 SLC5A11 0.41 8.52 0.43 5.73e-16 Ejection fraction in Tripanosoma cruzi seropositivity; CRC cis rs909674 0.541 rs5750816 chr22:39810379 A/G cg11247378 chr22:39784982 NA 0.47 9.17 0.45 5.39e-18 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; CRC cis rs7618915 0.547 rs2878726 chr3:52748271 C/G cg18404041 chr3:52824283 ITIH1 -0.43 -8.89 -0.44 4.01e-17 Bipolar disorder; CRC trans rs62295889 0.602 rs62293670 chr4:12542220 C/T cg03490839 chr16:73082051 ZFHX3 0.57 6.0 0.31 5.21e-9 Obesity-related traits; CRC cis rs7632954 0.567 rs6808372 chr3:8534693 T/C cg03495237 chr3:8533978 NA 0.35 6.38 0.33 5.85e-10 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs10274279 1.000 rs73163814 chr7:157388012 A/G cg26886268 chr7:157387156 PTPRN2 -0.48 -5.89 -0.31 9.62e-9 Myopia (pathological); CRC cis rs12594515 1.000 rs12595137 chr15:45986105 G/T cg19682013 chr15:45996608 NA 0.32 6.62 0.34 1.48e-10 Waist circumference;Weight; CRC trans rs57221529 0.600 rs11750269 chr5:666270 G/A cg25482853 chr8:67687455 SGK3 1.22 13.74 0.6 2.86e-34 Lung disease severity in cystic fibrosis; CRC cis rs881375 1.000 rs881375 chr9:123652898 T/C cg14255062 chr9:123606675 PSMD5;LOC253039 0.43 6.25 0.33 1.28e-9 Rheumatoid arthritis; CRC cis rs7474896 0.583 rs11011341 chr10:37998500 G/A cg25427524 chr10:38739819 LOC399744 -0.59 -7.48 -0.38 7.02e-13 Obesity (extreme); CRC cis rs6426558 0.559 rs7549520 chr1:227258858 G/C cg10327440 chr1:227177885 CDC42BPA 0.45 6.8 0.35 5.03e-11 Neutrophil percentage of white cells; CRC trans rs7615952 0.641 rs7618515 chr3:125790578 C/T cg07211511 chr3:129823064 LOC729375 -0.71 -9.71 -0.47 9.38e-20 Blood pressure (smoking interaction); CRC cis rs763121 0.853 rs5757187 chr22:39021522 A/G cg06544989 chr22:39130855 UNC84B -0.44 -6.95 -0.36 1.99e-11 Menopause (age at onset); CRC cis rs514406 0.571 rs11206004 chr1:53210958 G/A cg27535305 chr1:53392650 SCP2 0.33 6.17 0.32 2.03e-9 Monocyte count; CRC cis rs8180040 1.000 rs1024037 chr3:47318449 C/A cg02527881 chr3:46936655 PTH1R 0.39 6.98 0.36 1.59e-11 Colorectal cancer; CRC cis rs10464366 0.957 rs12667577 chr7:39095133 T/G cg15212455 chr7:39170539 POU6F2 0.45 5.69 0.3 2.82e-8 IgG glycosylation; CRC cis rs1691799 0.899 rs1168293 chr12:66733904 G/A cg16791601 chr12:66731901 HELB -0.66 -10.95 -0.52 5.35e-24 White blood cell count (basophil); CRC trans rs7618501 0.602 rs10049087 chr3:50123417 A/G cg21665057 chr3:196295764 WDR53;FBXO45 -0.62 -9.86 -0.48 2.97e-20 Intelligence (multi-trait analysis); CRC cis rs9389248 0.690 rs728030 chr6:135246294 G/T cg24558204 chr6:135376177 HBS1L -0.51 -7.53 -0.38 4.95e-13 High light scatter reticulocyte percentage of red cells; CRC cis rs11191205 0.686 rs11191088 chr10:103437266 C/G cg15320455 chr10:103880129 LDB1 -0.62 -6.85 -0.35 3.68e-11 Intelligence (multi-trait analysis); CRC cis rs7493 0.755 rs62467350 chr7:94970114 T/C cg21856205 chr7:94953877 PON1 -0.45 -5.9 -0.31 9.09e-9 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs9916302 0.595 rs4795371 chr17:37636695 T/G cg15445000 chr17:37608096 MED1 0.42 9.27 0.46 2.47e-18 Glomerular filtration rate (creatinine); CRC cis rs898097 0.578 rs2380173 chr17:80909157 G/T cg19046167 chr17:80928561 B3GNTL1 -0.43 -7.29 -0.37 2.26e-12 Breast cancer; CRC cis rs9443645 0.901 rs9448590 chr6:79606429 C/G cg11833968 chr6:79620685 NA -0.37 -6.48 -0.34 3.34e-10 Intelligence (multi-trait analysis); CRC trans rs2553218 0.690 rs8032415 chr15:54851945 A/G cg16155655 chr2:158485694 ACVR1C 0.45 6.36 0.33 6.68e-10 Immune response to smallpox vaccine (IL-6); CRC cis rs7671266 0.589 rs10938772 chr4:10375328 A/G cg00071950 chr4:10020882 SLC2A9 -0.43 -5.92 -0.31 8.28e-9 Cardiovascular disease risk factors; CRC cis rs7618501 0.521 rs3796386 chr3:49899795 G/A cg21467203 chr3:49911342 NA -0.25 -6.05 -0.32 4.03e-9 Intelligence (multi-trait analysis); CRC cis rs7677751 1.000 rs73252946 chr4:55125992 G/A cg17187183 chr4:55093834 PDGFRA 0.48 5.92 0.31 8.21e-9 Corneal astigmatism; CRC cis rs875971 0.540 rs1723268 chr7:65473080 A/C cg00343986 chr7:65444356 GUSB 0.57 8.62 0.43 2.85e-16 Aortic root size; CRC trans rs2321882 0.794 rs75393184 chr13:59477960 T/C cg04268950 chr11:130298854 ADAMTS8 -0.45 -5.99 -0.31 5.64e-9 Body mass index; CRC cis rs4665809 1.000 rs6546768 chr2:26328800 A/G cg22920501 chr2:26401640 FAM59B -0.52 -6.97 -0.36 1.78e-11 Gut microbiome composition (summer); CRC cis rs1691799 0.899 rs1168317 chr12:66746225 C/T cg16791601 chr12:66731901 HELB -0.73 -13.05 -0.58 1.14e-31 White blood cell count (basophil); CRC cis rs6582630 0.576 rs2387837 chr12:38403164 G/T cg13010199 chr12:38710504 ALG10B -0.4 -5.65 -0.3 3.44e-8 Drug-induced liver injury (flucloxacillin); CRC cis rs73200209 0.744 rs61936954 chr12:116473408 T/A cg01776926 chr12:116560359 MED13L -0.65 -7.58 -0.39 3.57e-13 Total body bone mineral density; CRC cis rs7493 1.000 rs12155103 chr7:95037131 G/A cg17330251 chr7:94953956 PON1 -0.56 -7.4 -0.38 1.17e-12 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs6463523 0.933 rs4724821 chr7:762544 C/T cg11064039 chr7:766100 PRKAR1B;HEATR2 0.9 15.65 0.65 1.22e-41 Subjective well-being; CRC cis rs7615952 0.599 rs2279821 chr3:125734308 G/A cg02772935 chr3:125709198 NA -0.52 -5.93 -0.31 7.7e-9 Blood pressure (smoking interaction); CRC cis rs11626933 1.000 rs4559843 chr14:90747488 T/C cg14092571 chr14:90743983 NA -0.94 -15.38 -0.65 1.29e-40 Gut microbiota (bacterial taxa); CRC cis rs9549328 0.765 rs1317506 chr13:113631143 C/T cg17524180 chr13:113633600 MCF2L -0.53 -9.77 -0.47 5.86e-20 Systolic blood pressure; CRC cis rs10744422 1.000 rs4759355 chr12:123316566 A/G cg25930673 chr12:123319894 HIP1R -0.6 -6.49 -0.34 3.08e-10 Schizophrenia; CRC cis rs4862750 0.832 rs10007858 chr4:187877492 A/G cg10295955 chr4:187884368 NA -1.03 -25.44 -0.81 1.08e-79 Lobe attachment (rater-scored or self-reported); CRC cis rs9303280 0.806 rs4795400 chr17:38067020 C/T cg17344932 chr17:38183730 MED24;SNORD124 0.39 6.26 0.33 1.23e-9 Self-reported allergy; CRC cis rs4253772 0.550 rs6008601 chr22:46705326 C/G cg24881330 chr22:46731750 TRMU 0.59 6.15 0.32 2.19e-9 LDL cholesterol;Cholesterol, total; CRC cis rs2243480 1.000 rs160642 chr7:65558373 C/T cg18252515 chr7:66147081 NA -1.14 -13.85 -0.61 1.06e-34 Diabetic kidney disease; CRC cis rs7584330 0.554 rs11892169 chr2:238432809 G/A cg14458575 chr2:238380390 NA 0.53 6.94 0.36 2.06e-11 Prostate cancer; CRC cis rs6732160 0.588 rs7578991 chr2:73376171 A/G cg01422370 chr2:73384389 NA 0.37 5.78 0.3 1.74e-8 Intelligence (multi-trait analysis); CRC cis rs6838801 0.752 rs13138237 chr4:77616562 C/G cg17476223 chr4:77663285 SHROOM3 0.44 5.89 0.31 9.8e-9 Cleft lip with or without cleft palate; CRC cis rs9311676 0.656 rs11917529 chr3:58382158 C/T cg06643156 chr3:58380774 PXK 0.41 6.33 0.33 7.82e-10 Systemic lupus erythematosus; CRC trans rs459571 0.834 rs379417 chr9:136890704 G/A cg15028160 chr19:49622717 PPFIA3;C19orf73 -0.58 -7.32 -0.37 1.98e-12 Platelet distribution width; CRC cis rs853679 0.517 rs9348797 chr6:28137533 G/C cg23161317 chr6:28129485 ZNF389 0.53 6.43 0.33 4.52e-10 Depression; CRC cis rs13108904 0.535 rs1250101 chr4:1236111 G/A cg16405210 chr4:1374714 KIAA1530 0.78 10.85 0.51 1.24e-23 Obesity-related traits; CRC cis rs270601 0.633 rs4535443 chr5:131572561 A/G cg09877947 chr5:131593287 PDLIM4 0.57 10.02 0.48 8.74e-21 Acylcarnitine levels; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg05505450 chr2:58273643 VRK2 0.46 6.68 0.35 1.05e-10 Response to antipsychotic treatment; CRC cis rs7635838 0.650 rs1375206 chr3:11339117 C/G cg00170343 chr3:11313890 ATG7 0.48 7.5 0.38 5.88e-13 HDL cholesterol; CRC trans rs116095464 0.558 rs73031482 chr5:227594 G/A cg00938859 chr5:1591904 SDHAP3 0.68 7.7 0.39 1.58e-13 Breast cancer; CRC cis rs4713118 0.869 rs9461400 chr6:27700559 A/G cg15845792 chr6:28175446 NA 0.65 9.11 0.45 7.98e-18 Parkinson's disease; CRC cis rs1348850 0.914 rs1348849 chr2:178358072 C/T cg02961200 chr2:178257176 LOC100130691;AGPS 0.62 9.17 0.45 5.23e-18 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs10782582 0.593 rs11164042 chr1:76178440 G/A cg03433033 chr1:76189801 ACADM -0.42 -6.13 -0.32 2.54e-9 Daytime sleep phenotypes; CRC cis rs8044995 0.636 rs117761434 chr16:68254196 G/A cg26727032 chr16:67993705 SLC12A4 -0.59 -6.31 -0.33 9.1e-10 Schizophrenia; CRC cis rs7635838 0.859 rs9875414 chr3:11453559 A/G cg00170343 chr3:11313890 ATG7 0.42 6.38 0.33 6.06e-10 HDL cholesterol; CRC cis rs9826463 0.702 rs9683274 chr3:142332110 A/G cg20824294 chr3:142316082 PLS1 0.37 5.8 0.3 1.57e-8 QRS duration in Tripanosoma cruzi seropositivity; CRC cis rs4629180 0.586 rs1509495 chr2:102134834 C/T cg04415270 chr2:102091202 RFX8 -0.37 -5.86 -0.31 1.12e-8 Chronic rhinosinusitis with nasal polyps; CRC cis rs561341 1.000 rs510264 chr17:30323414 A/G cg19193384 chr17:30244184 NA -0.66 -7.59 -0.39 3.4e-13 Hip circumference adjusted for BMI; CRC trans rs11098499 0.604 rs34278750 chr4:120571136 G/A cg25214090 chr10:38739885 LOC399744 0.57 8.54 0.43 5.01e-16 Corneal astigmatism; CRC cis rs910316 0.967 rs4903292 chr14:75656245 A/G cg03030879 chr14:75389066 RPS6KL1 -0.44 -6.92 -0.36 2.35e-11 Height; CRC cis rs7412746 0.658 rs11204750 chr1:150939744 C/A cg17724175 chr1:150552817 MCL1 0.47 7.0 0.36 1.46e-11 Melanoma; CRC cis rs875971 0.862 rs4718383 chr7:66108409 T/C cg18252515 chr7:66147081 NA 0.43 6.02 0.32 4.55e-9 Aortic root size; CRC cis rs4713118 0.955 rs9368529 chr6:27684631 G/A cg03623178 chr6:28175578 NA 0.63 8.41 0.42 1.3e-15 Parkinson's disease; CRC cis rs2836974 0.932 rs2150415 chr21:40615367 A/G cg06238570 chr21:40685208 BRWD1 0.78 10.82 0.51 1.48e-23 Cognitive function; CRC cis rs116095464 0.558 rs7714335 chr5:263513 T/C cg22857025 chr5:266934 NA -1.11 -14.17 -0.62 6.47e-36 Breast cancer; CRC cis rs1707322 1.000 rs10890376 chr1:46406582 C/T cg06784218 chr1:46089804 CCDC17 0.6 10.73 0.51 3.03e-23 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs877282 0.533 rs10904565 chr10:819991 G/T cg17470449 chr10:769945 NA 0.57 7.89 0.4 4.66e-14 Uric acid levels; CRC cis rs11711311 1.000 rs3732793 chr3:113442198 C/A cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.52 -7.0 -0.36 1.47e-11 IgG glycosylation; CRC cis rs4862750 0.872 rs6852907 chr4:187897094 A/C cg06074448 chr4:187884817 NA -0.58 -10.81 -0.51 1.71e-23 Lobe attachment (rater-scored or self-reported); CRC cis rs883565 0.528 rs4428122 chr3:38972603 C/A cg01426195 chr3:39028469 NA 0.42 7.09 0.36 8.22e-12 Handedness; CRC trans rs2832077 1.000 rs12329875 chr21:30137796 C/T cg14791747 chr16:20752902 THUMPD1 0.53 6.58 0.34 1.84e-10 Cognitive test performance; CRC cis rs9469578 1.000 rs16869466 chr6:33715265 A/G cg18708504 chr6:33715942 IP6K3 0.66 7.56 0.38 4e-13 Phosphorus levels; CRC cis rs951366 0.559 rs823101 chr1:205667006 T/C cg26354017 chr1:205819088 PM20D1 0.66 9.21 0.45 4.01e-18 Menarche (age at onset); CRC cis rs929354 1.000 rs1182389 chr7:157038803 C/T cg05182265 chr7:156933206 UBE3C -0.74 -14.08 -0.61 1.46e-35 Body mass index; CRC cis rs490234 0.783 rs13284243 chr9:128381785 A/G cg14078157 chr9:128172775 NA -0.39 -6.55 -0.34 2.21e-10 Mean arterial pressure; CRC cis rs897984 0.568 rs8063565 chr16:30883965 G/C cg02466173 chr16:30829666 NA 0.7 9.11 0.45 8.49e-18 Dementia with Lewy bodies; CRC cis rs10046574 0.831 rs28399231 chr7:135093154 G/A cg27474649 chr7:135195673 CNOT4 0.69 5.71 0.3 2.58e-8 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs4665809 1.000 rs10182857 chr2:26344411 C/T cg27170947 chr2:26402098 FAM59B -0.46 -6.1 -0.32 2.93e-9 Gut microbiome composition (summer); CRC cis rs4481887 0.861 rs10888345 chr1:248447533 A/G cg00666640 chr1:248458726 OR2T12 0.54 9.59 0.47 2.22e-19 Common traits (Other); CRC cis rs13108904 0.652 rs2878539 chr4:1243877 C/T cg19318889 chr4:1322082 MAEA 0.41 6.27 0.33 1.15e-9 Obesity-related traits; CRC cis rs9393692 0.905 rs9366649 chr6:26329103 A/T cg00631329 chr6:26305371 NA 0.67 13.14 0.59 5.45e-32 Educational attainment; CRC cis rs10504229 0.679 rs12679941 chr8:58051812 G/T cg24829409 chr8:58192753 C8orf71 -0.41 -5.67 -0.3 3.07e-8 Developmental language disorder (linguistic errors); CRC trans rs7615952 0.932 rs7630077 chr3:125649676 T/C cg02560186 chr11:3602584 NA -0.45 -6.12 -0.32 2.62e-9 Blood pressure (smoking interaction); CRC cis rs1552244 0.810 rs7612908 chr3:10089148 A/G cg13047869 chr3:10149882 C3orf24 0.57 7.8 0.4 8.27e-14 Alzheimer's disease; CRC cis rs3096299 0.685 rs2911244 chr16:89521860 A/G cg00750074 chr16:89608354 SPG7 -0.49 -7.56 -0.38 4.07e-13 Multiple myeloma (IgH translocation); CRC cis rs425277 1.000 rs262641 chr1:2104981 C/T cg24578937 chr1:2090814 PRKCZ -0.57 -10.15 -0.49 3.16e-21 Height; CRC cis rs6662572 0.671 rs12047120 chr1:46478496 A/G cg08644498 chr1:46502608 NA -0.46 -7.37 -0.38 1.4e-12 Blood protein levels; CRC cis rs7085104 0.514 rs284855 chr10:104574422 A/G cg23093090 chr10:104574429 C10orf26 0.4 6.58 0.34 1.91e-10 Immature fraction of reticulocytes;Schizophrenia; CRC cis rs2013441 0.866 rs12949485 chr17:20021661 A/G cg13482628 chr17:19912719 NA 0.41 6.0 0.31 5.14e-9 Obesity-related traits; CRC cis rs311392 1.000 rs454064 chr8:55088336 C/T cg20636351 chr8:55087400 NA -0.34 -6.01 -0.31 4.88e-9 Pelvic organ prolapse (moderate/severe); CRC cis rs3617 0.625 rs7620690 chr3:52891707 A/G cg07507251 chr3:52567010 NT5DC2 -0.41 -6.43 -0.33 4.55e-10 Red blood cell count;Autism spectrum disorder or schizophrenia; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg05780616 chr12:96252764 SNRPF 0.46 6.6 0.34 1.67e-10 Response to antipsychotic treatment; CRC cis rs2180341 0.711 rs4371861 chr6:127568447 G/T cg27446573 chr6:127587934 RNF146 0.55 7.81 0.4 7.72e-14 Breast cancer; CRC cis rs7632954 0.605 rs9824908 chr3:8524647 G/A cg03495237 chr3:8533978 NA 0.37 6.69 0.35 9.51e-11 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs1046896 0.562 rs2380172 chr17:80887719 C/A cg03160526 chr17:80928410 B3GNTL1 0.62 8.45 0.42 9.66e-16 Glycated hemoglobin levels; CRC trans rs12478296 0.901 rs9653611 chr2:243006956 C/G cg06834434 chr14:75079333 LTBP2 0.56 7.06 0.36 9.8e-12 Obesity-related traits; CRC cis rs7586879 0.593 rs10198275 chr2:25130542 A/C cg22495460 chr2:25135724 ADCY3 -0.88 -17.58 -0.7 2.99e-49 Body mass index; CRC cis rs7208859 0.524 rs59923796 chr17:29064919 G/A cg01831904 chr17:28903510 LRRC37B2 -0.62 -6.39 -0.33 5.7e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs2952156 0.920 rs12940986 chr17:37836581 A/G cg20243544 chr17:37824526 PNMT -0.56 -9.04 -0.45 1.36e-17 Asthma; CRC trans rs1005277 0.541 rs2472177 chr10:38384015 T/G cg23533926 chr12:111358616 MYL2 -0.53 -8.19 -0.41 5.92e-15 Extrinsic epigenetic age acceleration; CRC cis rs11209185 0.503 rs4655573 chr1:68438778 C/T cg22082780 chr1:68452167 NA -0.38 -5.78 -0.3 1.72e-8 Itch intensity from mosquito bite adjusted by bite size; CRC cis rs7274811 0.711 rs657040 chr20:32001292 A/G cg03904042 chr20:32255491 NECAB3;C20orf134 0.41 5.8 0.3 1.59e-8 Height; CRC cis rs6089584 0.566 rs6061972 chr20:60610245 C/T cg06108461 chr20:60628389 TAF4 -0.8 -13.22 -0.59 2.6e-32 Body mass index; CRC cis rs7107174 0.901 rs7110387 chr11:78117875 A/G cg02023728 chr11:77925099 USP35 0.42 6.3 0.33 9.33e-10 Testicular germ cell tumor; CRC cis rs4664308 0.967 rs56293836 chr2:160910958 T/C cg03641300 chr2:160917029 PLA2R1 -0.75 -12.51 -0.57 1.18e-29 Idiopathic membranous nephropathy; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg09844983 chr1:28240714 RPA2 0.47 6.15 0.32 2.27e-9 Thyroid stimulating hormone; CRC cis rs11098499 0.955 rs13114751 chr4:120156617 G/A cg09307838 chr4:120376055 NA 0.63 9.71 0.47 9.04e-20 Corneal astigmatism; CRC cis rs748404 0.697 rs501884 chr15:43553982 G/T cg02155558 chr15:43621948 ADAL;LCMT2 0.43 6.44 0.33 4.12e-10 Lung cancer; CRC cis rs7107174 0.892 rs1893449 chr11:77968977 G/C cg02023728 chr11:77925099 USP35 0.52 7.37 0.38 1.43e-12 Testicular germ cell tumor; CRC trans rs2018683 0.707 rs4722875 chr7:28969632 A/G cg19402173 chr7:128379420 CALU -0.42 -6.12 -0.32 2.61e-9 Response to irinotecan and platinum-based chemotherapy in non-small-cell lung cancer; CRC trans rs7395662 1.000 rs4882136 chr11:48615311 T/A cg21153622 chr11:89784906 NA -0.45 -7.22 -0.37 3.57e-12 HDL cholesterol; CRC cis rs9467603 1.000 rs9461216 chr6:25808743 A/T cg08501292 chr6:25962987 TRIM38 1.11 9.48 0.46 5.15e-19 Intelligence (multi-trait analysis); CRC trans rs11098499 0.691 rs9996494 chr4:120238880 C/A cg25214090 chr10:38739885 LOC399744 0.53 8.46 0.42 8.78e-16 Corneal astigmatism; CRC cis rs12928939 0.768 rs71386932 chr16:71816191 G/A cg03805757 chr16:71968109 PKD1L3 -0.47 -6.06 -0.32 3.75e-9 Post bronchodilator FEV1; CRC cis rs6963495 0.818 rs117028299 chr7:105162310 T/C cg02135003 chr7:105160482 PUS7 -0.9 -12.2 -0.56 1.71e-28 Bipolar disorder (body mass index interaction); CRC cis rs9868809 0.505 rs9811027 chr3:48725014 G/C cg07636037 chr3:49044803 WDR6 -0.66 -6.41 -0.33 5.06e-10 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; CRC cis rs7811142 0.562 rs7786844 chr7:99934008 T/G cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.61 8.22 0.41 4.81e-15 Platelet count; CRC cis rs1552244 0.572 rs73117481 chr3:10160132 C/T cg10729496 chr3:10149963 C3orf24 0.48 5.61 0.3 4.19e-8 Alzheimer's disease; CRC cis rs4975616 0.843 rs4975615 chr5:1315343 C/T cg06550200 chr5:1325588 CLPTM1L 0.61 9.36 0.46 1.32e-18 Lung cancer; CRC cis rs4819052 0.851 rs8131143 chr21:46671646 C/G cg19498844 chr21:46707878 POFUT2;LOC642852 -0.76 -10.99 -0.52 3.81e-24 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs4148883 0.628 rs34195655 chr4:100073795 C/T cg12011299 chr4:100065546 ADH4 0.5 10.96 0.52 4.83e-24 Alcohol dependence; CRC cis rs9660992 0.710 rs1151787 chr1:205254238 G/A cg21643547 chr1:205240462 TMCC2 -0.45 -7.34 -0.38 1.69e-12 Mean corpuscular volume;Mean platelet volume; CRC cis rs739401 0.566 rs7931504 chr11:3026712 C/T cg05729581 chr11:3078854 CARS -0.59 -8.66 -0.43 2.23e-16 Longevity; CRC cis rs16867321 0.853 rs12464199 chr2:181333307 A/G cg23363182 chr2:181467187 NA 0.51 6.15 0.32 2.26e-9 Obesity; CRC cis rs6743376 0.556 rs768627 chr2:113821653 C/T cg24553058 chr2:113831203 IL1F10 -0.43 -7.09 -0.36 8.16e-12 Inflammatory biomarkers; CRC cis rs2836974 1.000 rs2836974 chr21:40663181 A/G cg17971929 chr21:40555470 PSMG1 -0.81 -11.54 -0.54 4.13e-26 Cognitive function; CRC cis rs8141529 0.732 rs5997408 chr22:29207915 G/A cg02153584 chr22:29168773 CCDC117 0.51 7.51 0.38 5.52e-13 Lymphocyte counts; CRC cis rs853679 0.517 rs4713137 chr6:28083521 C/G cg02631126 chr6:28058918 ZSCAN12L1 0.29 5.87 0.31 1.05e-8 Depression; CRC cis rs1451375 0.652 rs7779110 chr7:50625651 T/C cg14593290 chr7:50529359 DDC 0.6 8.0 0.4 2.18e-14 Malaria; CRC trans rs55986470 0.670 rs56313033 chr2:239346202 C/T cg01134436 chr17:81009848 B3GNTL1 0.76 7.09 0.36 8.43e-12 Chronotype; CRC cis rs6968419 0.609 rs73716710 chr7:115905744 G/A cg02561103 chr7:115862891 TES -0.41 -6.14 -0.32 2.35e-9 Intraocular pressure; CRC cis rs6662572 0.703 rs7556472 chr1:46339811 G/A cg03123370 chr1:45965343 CCDC163P;MMACHC -0.46 -5.9 -0.31 8.93e-9 Blood protein levels; CRC cis rs9549260 0.564 rs7997896 chr13:41268823 T/A cg21288729 chr13:41239152 FOXO1 0.44 6.71 0.35 8.37e-11 Red blood cell count; CRC trans rs17685 0.753 rs10233282 chr7:75790081 C/T cg19862616 chr7:65841803 NCRNA00174 0.97 16.87 0.68 1.91e-46 Coffee consumption;Coffee consumption (cups per day); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg12463110 chr4:54930242 CHIC2 0.49 7.18 0.37 4.81e-12 Response to antipsychotic treatment; CRC cis rs7809950 0.954 rs62482543 chr7:107080656 G/A cg23024343 chr7:107201750 COG5 -0.62 -8.77 -0.44 9.83e-17 Coronary artery disease; CRC cis rs1949733 0.628 rs2688231 chr4:8490981 G/A cg11789530 chr4:8429930 ACOX3 0.8 12.0 0.55 9.25e-28 Response to antineoplastic agents; CRC cis rs6793245 0.845 rs4073796 chr3:38590849 G/A cg01465620 chr3:38496096 LOC100128640;ACVR2B -0.56 -8.3 -0.42 2.77e-15 QT interval; CRC trans rs9903692 0.954 rs12450620 chr17:46130254 G/T cg13910583 chr8:56987998 RPS20 -0.44 -5.99 -0.31 5.63e-9 Pulse pressure; CRC cis rs853679 0.542 rs6934769 chr6:28090931 A/G cg15786705 chr6:28176104 NA 0.77 9.75 0.47 6.92e-20 Depression; CRC cis rs881375 0.967 rs1860823 chr9:123659304 T/C cg09419670 chr9:123605666 PSMD5;LOC253039 0.6 8.83 0.44 6.45e-17 Rheumatoid arthritis; CRC cis rs4819052 0.851 rs4819039 chr21:46659458 G/A cg11663144 chr21:46675770 NA -0.83 -14.12 -0.61 9.88e-36 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg17675882 chr20:35374068 NDRG3 0.54 7.26 0.37 2.86e-12 Thyroid stimulating hormone; CRC cis rs10504229 0.610 rs6993531 chr8:58147283 A/G cg02725872 chr8:58115012 NA -0.59 -11.12 -0.52 1.3e-24 Developmental language disorder (linguistic errors); CRC cis rs11711311 0.736 rs2278941 chr3:113350508 A/G cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.5 -6.72 -0.35 8.24e-11 IgG glycosylation; CRC cis rs2243480 1.000 rs34192067 chr7:65887657 C/A cg18252515 chr7:66147081 NA -1.3 -15.32 -0.65 2.37e-40 Diabetic kidney disease; CRC cis rs661713 0.734 rs2655387 chr6:90947998 T/C cg06866423 chr6:90926672 BACH2 0.39 5.69 0.3 2.77e-8 Hypothyroidism; CRC cis rs2479724 0.755 rs4318867 chr6:41753670 G/T cg17623882 chr6:41773611 USP49 0.52 8.69 0.43 1.77e-16 Menarche (age at onset); CRC cis rs910316 0.737 rs175499 chr14:75535927 G/A cg03030879 chr14:75389066 RPS6KL1 0.4 6.11 0.32 2.86e-9 Height; CRC cis rs62064224 0.614 rs4794923 chr17:30763009 G/A cg18200150 chr17:30822561 MYO1D 0.47 9.17 0.45 5.17e-18 Schizophrenia; CRC trans rs1728785 1.000 rs1728789 chr16:68595776 C/T cg04657470 chr2:198365150 HSPE1;HSPD1 0.59 7.14 0.37 5.95e-12 Ulcerative colitis; CRC cis rs7224685 0.501 rs4790559 chr17:4010478 G/T cg09695851 chr17:3907499 NA -0.79 -14.43 -0.62 6.36e-37 Type 2 diabetes; CRC cis rs12580194 0.593 rs7485979 chr12:55789043 A/T cg19537932 chr12:55886519 OR6C68 0.7 9.09 0.45 9.41e-18 Cancer; CRC cis rs501120 0.925 rs494045 chr10:44773498 C/T cg09554077 chr10:44749378 NA 0.73 10.63 0.51 7e-23 Coronary artery disease;Coronary heart disease; CRC cis rs909674 0.818 rs5757681 chr22:39845547 A/G cg24399712 chr22:39784796 NA -0.4 -7.58 -0.39 3.64e-13 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; CRC cis rs4664293 0.967 rs1346325 chr2:160542506 C/T cg08347373 chr2:160653686 CD302 -0.44 -7.09 -0.36 8.07e-12 Monocyte percentage of white cells; CRC cis rs727563 0.648 rs6002406 chr22:41965237 A/T cg06481639 chr22:41940642 POLR3H -0.55 -5.9 -0.31 9.22e-9 Crohn's disease;Inflammatory bowel disease; CRC cis rs6840360 0.593 rs867800 chr4:152691470 T/C cg22705602 chr4:152727874 NA -0.34 -5.79 -0.3 1.63e-8 Intelligence (multi-trait analysis); CRC cis rs1355223 0.506 rs12294339 chr11:34860199 C/T cg11058730 chr11:34937778 PDHX;APIP -0.41 -5.65 -0.3 3.47e-8 Systemic lupus erythematosus and Systemic sclerosis; CRC cis rs6120849 0.754 rs11167253 chr20:33614449 T/C cg08999081 chr20:33150536 PIGU 0.45 5.79 0.3 1.66e-8 Protein C levels; CRC cis rs8180040 0.903 rs11130124 chr3:47292183 T/C cg10298567 chr3:47292165 KIF9 -0.41 -6.66 -0.34 1.14e-10 Colorectal cancer; CRC cis rs6499255 0.951 rs8046314 chr16:69697922 T/A cg15192750 chr16:69999425 NA 0.57 7.69 0.39 1.75e-13 IgE levels; CRC cis rs1129187 0.791 rs1129186 chr6:42932202 C/T cg09436375 chr6:42928200 GNMT -0.34 -6.46 -0.34 3.81e-10 Alzheimer's disease in APOE e4+ carriers; CRC cis rs7264396 0.690 rs2425165 chr20:34438059 C/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.59 -10.11 -0.49 4.17e-21 Total cholesterol levels; CRC cis rs4321325 0.733 rs78593261 chr2:127947044 G/A cg11380483 chr2:127933992 NA 0.62 7.02 0.36 1.25e-11 Protein C levels; CRC cis rs1997103 0.906 rs4618644 chr7:55402037 T/G cg17469321 chr7:55412551 NA 0.73 11.31 0.53 2.87e-25 QRS interval (sulfonylurea treatment interaction); CRC trans rs11039798 1.000 rs7125559 chr11:48984207 C/G cg03929089 chr4:120376271 NA 0.64 6.1 0.32 2.95e-9 Axial length; CRC cis rs2836950 0.565 rs8131132 chr21:40538256 T/C cg11890956 chr21:40555474 PSMG1 -0.66 -9.97 -0.48 1.28e-20 Menarche (age at onset); CRC cis rs6951245 0.554 rs2070118 chr7:1132505 G/A cg26224354 chr7:1096374 C7orf50;GPR146 -0.66 -8.97 -0.44 2.25e-17 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs1799949 0.965 rs799908 chr17:41278916 A/G cg05368731 chr17:41323189 NBR1 0.63 9.57 0.47 2.74e-19 Menopause (age at onset); CRC cis rs7666738 0.791 rs11730069 chr4:98945772 A/G cg05340658 chr4:99064831 C4orf37 0.61 9.54 0.47 3.45e-19 Colonoscopy-negative controls vs population controls; CRC cis rs1862618 0.671 rs832531 chr5:56228401 A/G cg24531977 chr5:56204891 C5orf35 -0.67 -10.33 -0.49 7.34e-22 Initial pursuit acceleration; CRC cis rs7512552 0.839 rs6662108 chr1:150420541 G/T cg15654264 chr1:150340011 RPRD2 0.58 8.25 0.41 3.75e-15 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); CRC cis rs6831256 1.000 rs10007119 chr4:3473066 A/G cg04192923 chr4:3473232 DOK7 0.38 6.01 0.31 4.88e-9 LDL cholesterol;Triglyceride levels;Triglycerides;Cholesterol, total; CRC cis rs9372498 0.536 rs9489428 chr6:118852935 T/C cg18833306 chr6:118973337 C6orf204 0.45 6.01 0.31 4.81e-9 Diastolic blood pressure; CRC cis rs10504229 0.610 rs7840469 chr8:58146992 C/T cg24829409 chr8:58192753 C8orf71 -0.52 -8.12 -0.41 9.7e-15 Developmental language disorder (linguistic errors); CRC cis rs6088580 0.634 rs6059878 chr20:33087166 A/T cg08999081 chr20:33150536 PIGU 0.63 11.63 0.54 1.96e-26 Glomerular filtration rate (creatinine); CRC cis rs4332037 0.539 rs4470910 chr7:2071723 C/T cg25834613 chr7:1915315 MAD1L1 -0.42 -5.95 -0.31 7.03e-9 Bipolar disorder; CRC cis rs6866344 0.697 rs11749438 chr5:178131245 C/T cg03877680 chr5:178157825 ZNF354A 0.77 10.62 0.51 7.77e-23 Neutrophil percentage of white cells; CRC cis rs938554 0.735 rs11942223 chr4:9962765 T/C cg00071950 chr4:10020882 SLC2A9 -0.44 -6.01 -0.31 4.97e-9 Blood metabolite levels; CRC cis rs1044826 0.619 rs7375091 chr3:139090389 T/A cg15131784 chr3:139108705 COPB2 -0.41 -5.95 -0.31 6.93e-9 Obesity-related traits; CRC cis rs9462027 0.628 rs7756405 chr6:34722659 G/A cg07306190 chr6:34760872 UHRF1BP1 -0.35 -6.19 -0.32 1.75e-9 Systemic lupus erythematosus; CRC cis rs11971779 0.680 rs2355783 chr7:139075879 C/T cg07862535 chr7:139043722 LUC7L2 0.57 7.35 0.38 1.61e-12 Diisocyanate-induced asthma; CRC cis rs9733 0.596 rs72702570 chr1:150688196 C/T cg15448220 chr1:150897856 SETDB1 0.45 6.41 0.33 5.09e-10 Tonsillectomy; CRC cis rs6570726 0.791 rs2096201 chr6:145934273 C/T cg13319975 chr6:146136371 FBXO30 -0.46 -6.89 -0.36 2.89e-11 Lobe attachment (rater-scored or self-reported); CRC cis rs3617 0.591 rs2276823 chr3:52869263 C/A cg11645453 chr3:52864694 ITIH4 -0.46 -9.13 -0.45 6.9e-18 Red blood cell count;Autism spectrum disorder or schizophrenia; CRC trans rs56037433 1 rs56037433 chr2:162575985 G/A cg14875682 chr5:52083620 ITGA1;PELO -0.78 -6.1 -0.32 3.05e-9 Bipolar disorder or attention deficit hyperactivity disorder; CRC cis rs477895 0.653 rs11606544 chr11:63896901 C/T cg19465662 chr11:63993652 NUDT22;TRPT1 0.73 8.98 0.44 2.15e-17 Mean platelet volume; CRC cis rs9291683 0.546 rs4529049 chr4:10045389 C/T cg11266682 chr4:10021025 SLC2A9 0.52 10.75 0.51 2.57e-23 Bone mineral density; CRC cis rs8060686 0.545 rs76836953 chr16:68061763 G/C cg08314208 chr16:67682810 RLTPR -0.65 -6.8 -0.35 5.04e-11 HDL cholesterol;Metabolic syndrome; CRC cis rs362272 0.524 rs7435601 chr4:3369645 A/G cg11522145 chr4:3412961 RGS12 -0.36 -5.69 -0.3 2.85e-8 Serum sulfate level; CRC cis rs11677370 0.603 rs10171309 chr2:3851690 C/T cg17052675 chr2:3827356 NA -0.66 -11.06 -0.52 2.15e-24 Type 2 diabetes; CRC cis rs4481887 0.927 rs4282853 chr1:248475127 A/G cg00666640 chr1:248458726 OR2T12 0.48 8.14 0.41 7.98e-15 Common traits (Other); CRC cis rs6951245 0.744 rs1133122 chr7:1192572 C/A cg24642844 chr7:1081250 C7orf50 -0.68 -8.35 -0.42 1.9e-15 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs2067615 0.524 rs4964483 chr12:107099057 T/C cg15890332 chr12:107067104 RFX4 0.32 5.66 0.3 3.37e-8 Heart rate; CRC cis rs7927771 0.524 rs4752860 chr11:47705015 C/A cg20307385 chr11:47447363 PSMC3 -0.48 -7.14 -0.37 5.92e-12 Subjective well-being; CRC cis rs4731207 0.596 rs1600745 chr7:124585183 G/C cg23710748 chr7:124431027 NA -0.38 -6.08 -0.32 3.35e-9 Cutaneous malignant melanoma; CRC cis rs7617773 0.780 rs13084616 chr3:48339699 A/G cg11946769 chr3:48343235 NME6 -0.73 -9.95 -0.48 1.42e-20 Coronary artery disease; CRC cis rs71403859 0.730 rs35390364 chr16:71740049 A/G cg08717414 chr16:71523259 ZNF19 -1.0 -9.05 -0.45 1.24e-17 Post bronchodilator FEV1; CRC cis rs1008375 1.000 rs10019856 chr4:17615742 T/A cg02297831 chr4:17616191 MED28 0.44 5.74 0.3 2.14e-8 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs4803468 1.000 rs284654 chr19:41928724 G/A cg09537434 chr19:41945824 ATP5SL -0.97 -18.69 -0.72 1.26e-53 Height; CRC cis rs892085 0.681 rs873016 chr19:10894728 G/A cg17710535 chr19:10819994 QTRT1 0.39 5.8 0.3 1.56e-8 Psoriasis vulgaris;Psoriasis; CRC cis rs6662572 0.686 rs72677546 chr1:46577716 C/T cg08644498 chr1:46502608 NA 0.46 7.31 0.37 2.11e-12 Blood protein levels; CRC cis rs61008539 0.893 rs7783487 chr7:860160 A/C cg00475322 chr7:917719 C7orf20 0.44 7.82 0.4 7.3e-14 Perceived unattractiveness to mosquitoes; CRC cis rs4713118 0.513 rs149945 chr6:28002853 T/C cg20615401 chr6:28092323 ZSCAN16 0.46 6.23 0.32 1.47e-9 Parkinson's disease; CRC cis rs698833 0.828 rs786623 chr2:44606171 C/T cg04920474 chr2:44395004 PPM1B 0.42 6.23 0.32 1.4e-9 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; CRC cis rs6952808 0.501 rs3778999 chr7:2180885 G/A cg02951883 chr7:2050386 MAD1L1 -0.6 -8.85 -0.44 5.35e-17 Bipolar disorder and schizophrenia; CRC cis rs4731207 0.724 rs35535003 chr7:124442464 A/T cg23710748 chr7:124431027 NA 0.37 5.96 0.31 6.53e-9 Cutaneous malignant melanoma; CRC trans rs7618501 0.902 rs7645061 chr3:49868842 C/T cg21659725 chr3:3221576 CRBN 0.91 17.77 0.7 5.22e-50 Intelligence (multi-trait analysis); CRC cis rs7811142 0.945 rs6955362 chr7:100056166 C/T cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.63 8.24 0.41 4.27e-15 Platelet count; CRC cis rs6662572 0.901 rs58692133 chr1:46067269 G/A cg03123370 chr1:45965343 CCDC163P;MMACHC 0.48 5.7 0.3 2.6e-8 Blood protein levels; CRC cis rs782590 0.557 rs7592219 chr2:55887176 T/C cg18811423 chr2:55921094 PNPT1 -0.65 -8.97 -0.44 2.3e-17 Metabolic syndrome; CRC cis rs1218582 0.772 rs1976559 chr1:154879788 A/T cg09359103 chr1:154839909 KCNN3 -0.71 -12.5 -0.57 1.33e-29 Prostate cancer; CRC cis rs7772486 0.805 rs4896831 chr6:145959481 T/C cg13319975 chr6:146136371 FBXO30 -0.39 -5.82 -0.31 1.43e-8 Lobe attachment (rater-scored or self-reported); CRC cis rs12143943 0.934 rs1563827 chr1:204579139 C/T cg17419461 chr1:204415978 PIK3C2B 0.37 5.81 0.3 1.51e-8 Cognitive performance; CRC trans rs60843830 0.964 rs7584915 chr2:264227 G/A cg11347411 chr7:150020925 ACTR3C;LRRC61 0.56 8.72 0.43 1.42e-16 Spherical equivalent (joint analysis main effects and education interaction); CRC cis rs7618915 0.547 rs11130317 chr3:52731483 C/T cg11645453 chr3:52864694 ITIH4 0.35 6.09 0.32 3.07e-9 Bipolar disorder; CRC cis rs4665809 0.590 rs13006973 chr2:26454707 C/T cg22920501 chr2:26401640 FAM59B 0.83 11.96 0.55 1.28e-27 Gut microbiome composition (summer); CRC cis rs6696846 0.765 rs61822567 chr1:205078725 T/C cg00857998 chr1:205179979 DSTYK 0.45 6.25 0.33 1.3e-9 Red blood cell count; CRC cis rs7131987 0.934 rs2216854 chr12:29423460 G/A cg09582351 chr12:29534625 ERGIC2 -0.29 -6.25 -0.33 1.25e-9 QT interval; CRC trans rs61931739 0.500 rs11053251 chr12:34520743 A/G cg26384229 chr12:38710491 ALG10B 0.61 9.09 0.45 9.33e-18 Morning vs. evening chronotype; CRC cis rs4332037 0.906 rs6461009 chr7:1952139 T/C cg25834613 chr7:1915315 MAD1L1 0.4 5.92 0.31 8.25e-9 Bipolar disorder; CRC cis rs713477 0.935 rs10144034 chr14:55914273 C/A cg13175173 chr14:55914753 NA -0.52 -9.94 -0.48 1.57e-20 Pediatric bone mineral content (femoral neck); CRC cis rs7149337 0.805 rs2999361 chr14:51605358 G/A cg18683604 chr14:51561293 TRIM9 0.29 5.87 0.31 1.08e-8 Cancer; CRC cis rs1153858 1.000 rs59889118 chr15:45618730 G/A cg21132104 chr15:45694354 SPATA5L1 0.58 8.27 0.41 3.38e-15 Homoarginine levels; CRC cis rs7666738 0.927 rs11736876 chr4:98987206 A/G cg17366294 chr4:99064904 C4orf37 0.45 7.31 0.37 2.08e-12 Colonoscopy-negative controls vs population controls; CRC cis rs10782582 0.609 rs5745469 chr1:76347394 G/A cg10523679 chr1:76189770 ACADM -0.41 -5.7 -0.3 2.73e-8 Daytime sleep phenotypes; CRC cis rs7727544 0.735 rs2631370 chr5:131703776 T/C cg07395648 chr5:131743802 NA 0.41 6.43 0.33 4.42e-10 Blood metabolite levels; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg07410086 chr14:35515858 FAM177A1 0.46 6.28 0.33 1.08e-9 Response to antipsychotic treatment; CRC cis rs1215050 0.782 rs6853916 chr4:98653387 C/T cg05340658 chr4:99064831 C4orf37 -0.47 -7.01 -0.36 1.4e-11 Waist-to-hip ratio adjusted for body mass index; CRC trans rs4263408 0.934 rs9683743 chr4:39703194 A/C cg02001571 chr14:50319805 SDCCAG1 -0.41 -6.0 -0.31 5.32e-9 Plasma amyloid beta peptide concentrations (ABx-40); CRC trans rs2797160 0.905 rs1418641 chr6:125999854 C/T cg05039488 chr6:79577232 IRAK1BP1 -0.5 -7.55 -0.38 4.4e-13 Endometrial cancer; CRC cis rs6860806 0.507 rs183898 chr5:131716902 C/G cg07395648 chr5:131743802 NA 0.41 5.77 0.3 1.81e-8 Breast cancer; CRC cis rs995000 0.931 rs2366638 chr1:63099577 G/A cg19896129 chr1:63156450 NA 0.41 6.41 0.33 5.18e-10 Triglyceride levels; CRC cis rs62064224 0.791 rs2344977 chr17:30720573 C/G cg24550644 chr17:30846204 MYO1D -0.35 -5.69 -0.3 2.81e-8 Schizophrenia; CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg00137828 chr10:105881754 C10orf78 0.39 6.2 0.32 1.69e-9 Obesity-related traits; CRC cis rs10256972 0.706 rs4285396 chr7:1123738 A/G cg23978390 chr7:1156363 C7orf50 0.51 6.93 0.36 2.23e-11 Longevity;Endometriosis; CRC cis rs6662572 0.737 rs6429592 chr1:46472153 G/A cg08644498 chr1:46502608 NA -0.47 -7.46 -0.38 7.64e-13 Blood protein levels; CRC cis rs73206853 0.698 rs56327628 chr12:111117931 A/C cg12870014 chr12:110450643 ANKRD13A 0.78 8.0 0.4 2.15e-14 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC cis rs853679 0.550 rs1233699 chr6:28169158 A/T cg15845792 chr6:28175446 NA 1.03 15.85 0.66 1.9e-42 Depression; CRC cis rs734999 0.566 rs10797435 chr1:2534801 G/C cg20673091 chr1:2541236 MMEL1 0.37 6.02 0.31 4.78e-9 Ulcerative colitis; CRC cis rs1577917 0.740 rs2475792 chr6:86392102 C/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A 0.57 8.09 0.41 1.15e-14 Response to antipsychotic treatment; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg11249215 chr1:110036563 CYB561D1 0.41 6.58 0.34 1.91e-10 Response to antipsychotic treatment; CRC cis rs9894429 0.869 rs9748184 chr17:79596280 A/G cg21028142 chr17:79581711 NPLOC4 0.38 8.32 0.42 2.38e-15 Eye color traits; CRC cis rs3857536 0.813 rs6904511 chr6:66939102 A/C cg07460842 chr6:66804631 NA -0.43 -5.81 -0.3 1.48e-8 Blood trace element (Cu levels); CRC cis rs1008375 1.000 rs10939743 chr4:17662731 G/A cg16339924 chr4:17578868 LAP3 0.53 6.96 0.36 1.87e-11 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs12410462 0.581 rs77837509 chr1:227559873 C/T cg23173402 chr1:227635558 NA 0.72 6.77 0.35 5.97e-11 Major depressive disorder; CRC cis rs6860806 0.507 rs272891 chr5:131664394 G/T cg27615366 chr5:131592974 PDLIM4 0.33 5.77 0.3 1.8e-8 Breast cancer; CRC cis rs12681287 0.640 rs10095498 chr8:87425651 C/T cg27223183 chr8:87520930 FAM82B 0.51 6.9 0.36 2.75e-11 Caudate activity during reward; CRC cis rs6951245 0.938 rs78351779 chr7:1097023 G/C cg22907277 chr7:1156413 C7orf50 0.72 7.6 0.39 3.1400000000000003e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC trans rs2303319 0.504 rs56371522 chr2:162491109 G/A cg04269497 chr6:167369491 RNASET2 -0.74 -6.06 -0.32 3.72e-9 Cognitive function; CRC cis rs4953076 0.533 rs10173126 chr2:44446492 T/C cg04920474 chr2:44395004 PPM1B 0.59 7.56 0.38 4.04e-13 Height; CRC cis rs951366 0.589 rs823099 chr1:205669322 C/A cg07157834 chr1:205819609 PM20D1 0.76 10.91 0.52 7.4e-24 Menarche (age at onset); CRC cis rs6545883 0.524 rs4599092 chr2:61498968 T/G cg10580144 chr2:61372316 C2orf74 -0.35 -7.81 -0.4 7.78e-14 Tuberculosis; CRC trans rs7267979 0.966 rs2263204 chr20:25377688 A/T cg17903999 chr18:56338584 MALT1 0.42 6.86 0.35 3.4e-11 Liver enzyme levels (alkaline phosphatase); CRC cis rs1008375 1.000 rs7661631 chr4:17679751 T/C cg04450456 chr4:17643702 FAM184B -0.37 -5.85 -0.31 1.19e-8 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs7786808 0.552 rs896762 chr7:158182029 A/G cg15440763 chr7:158190612 PTPRN2 -0.52 -8.31 -0.42 2.58e-15 Obesity-related traits; CRC trans rs783540 0.934 rs1594511 chr15:83307063 T/A cg18393722 chr15:85113863 UBE2QP1 -0.39 -6.48 -0.34 3.4e-10 Schizophrenia; CRC cis rs12519773 0.526 rs4869415 chr5:92522764 A/G cg18783429 chr5:92414398 NA 0.29 6.13 0.32 2.58e-9 Migraine; CRC cis rs9916302 0.660 rs665413 chr17:37455678 T/A cg07936489 chr17:37558343 FBXL20 0.9 11.41 0.53 1.21e-25 Glomerular filtration rate (creatinine); CRC cis rs2952156 0.920 rs2934951 chr17:37833328 A/G cg20243544 chr17:37824526 PNMT 0.55 8.87 0.44 4.67e-17 Asthma; CRC cis rs6933660 0.720 rs6913515 chr6:151753470 G/C cg14416726 chr6:151773293 C6orf211;RMND1 -0.58 -8.78 -0.44 9.14e-17 Menarche (age at onset); CRC cis rs6500602 0.592 rs28789232 chr16:4447552 C/A cg14951292 chr16:4525986 HMOX2;NMRAL1 0.63 7.31 0.37 2.02e-12 Schizophrenia; CRC cis rs7617773 0.539 rs12486935 chr3:48390164 C/T cg11946769 chr3:48343235 NME6 0.61 8.2 0.41 5.38e-15 Coronary artery disease; CRC cis rs6964587 1.000 rs10234434 chr7:91673308 A/T cg17063962 chr7:91808500 NA 0.8 13.98 0.61 3.58e-35 Breast cancer; CRC cis rs7945705 0.870 rs4929922 chr11:8975776 A/G cg00186954 chr11:8933980 ST5;C11orf17 -0.47 -6.88 -0.35 2.94e-11 Hemoglobin concentration; CRC trans rs1642645 0.831 rs2886564 chr1:42496924 G/A cg16926213 chr1:1841314 NA -0.43 -6.05 -0.32 3.88e-9 Left ventricular obstructive tract defect (maternal effect); CRC cis rs11711311 1.000 rs12497716 chr3:113453258 C/T cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.51 -7.02 -0.36 1.31e-11 IgG glycosylation; CRC cis rs6500602 0.893 rs934888 chr16:4462832 C/T cg14951292 chr16:4525986 HMOX2;NMRAL1 0.65 8.48 0.42 7.88e-16 Schizophrenia; CRC trans rs2834485 1.000 rs5010906 chr21:35818590 G/C cg07474852 chr4:123073612 NA 0.55 8.02 0.4 1.93e-14 Cancer; CRC cis rs477895 0.653 rs3824854 chr11:63885305 C/T cg18225595 chr11:63971243 STIP1 0.54 7.05 0.36 1.04e-11 Mean platelet volume; CRC cis rs17152411 0.895 rs7094381 chr10:126585848 G/A cg07906193 chr10:126599966 NA 0.56 6.33 0.33 7.97e-10 Height; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg24125890 chr12:21654287 RECQL;GOLT1B 0.46 5.96 0.31 6.37e-9 Thyroid stimulating hormone; CRC cis rs1153858 0.943 rs7402632 chr15:45701913 A/T cg14582100 chr15:45693742 SPATA5L1 0.28 5.63 0.3 3.9e-8 Homoarginine levels; CRC cis rs7618915 0.501 rs2336146 chr3:52626646 A/G cg10802521 chr3:52805072 NEK4 -0.58 -9.07 -0.45 1.13e-17 Bipolar disorder; CRC cis rs10504229 0.683 rs16921829 chr8:58110950 A/G cg05313129 chr8:58192883 C8orf71 -0.43 -5.98 -0.31 5.89e-9 Developmental language disorder (linguistic errors); CRC cis rs12791968 1.000 rs10838397 chr11:45009133 A/G cg11846598 chr11:44996168 LOC221122 0.69 12.14 0.56 2.85e-28 Inhibitory control; CRC cis rs780096 0.506 rs2950834 chr2:27627366 G/A cg21248554 chr2:27665150 KRTCAP3 -0.32 -7.31 -0.37 2.1e-12 Total body bone mineral density; CRC cis rs9894429 0.934 rs35868252 chr17:79575472 C/G cg13777783 chr17:79615861 NA 0.3 5.72 0.3 2.44e-8 Eye color traits; CRC cis rs11148252 0.553 rs2147692 chr13:53287023 C/G cg12458913 chr13:53173898 NA 0.79 15.21 0.64 6.06e-40 Lewy body disease; CRC trans rs10983614 1.000 rs7867776 chr9:120072627 A/G cg14067770 chr11:615950 IRF7 0.49 6.85 0.35 3.72e-11 Survival in pancreatic cancer; CRC cis rs11971779 0.650 rs10085842 chr7:139064582 A/G cg23387468 chr7:139079360 LUC7L2 0.41 7.04 0.36 1.14e-11 Diisocyanate-induced asthma; CRC cis rs875971 0.862 rs1167408 chr7:65556108 G/A cg18252515 chr7:66147081 NA 0.4 5.9 0.31 9.26e-9 Aortic root size; CRC cis rs4731207 0.596 rs1481329 chr7:124631334 A/G cg23710748 chr7:124431027 NA -0.39 -6.34 -0.33 7.73e-10 Cutaneous malignant melanoma; CRC trans rs9929218 1.000 rs8056538 chr16:68802282 C/T cg04657470 chr2:198365150 HSPE1;HSPD1 -0.82 -11.59 -0.54 2.74e-26 Colorectal cancer; CRC cis rs992157 0.835 rs13031757 chr2:219151926 T/C cg00012203 chr2:219082015 ARPC2 -0.47 -7.08 -0.36 8.67e-12 Colorectal cancer; CRC cis rs801193 1.000 rs2055682 chr7:66260289 A/G cg18876405 chr7:65276391 NA 0.57 9.93 0.48 1.72e-20 Aortic root size; CRC cis rs950169 0.545 rs4842841 chr15:84641125 G/A cg24253500 chr15:84953950 NA 0.38 6.01 0.31 4.96e-9 Schizophrenia; CRC cis rs2742417 0.603 rs2064064 chr3:45759995 C/T cg04837898 chr3:45731254 SACM1L -0.49 -7.88 -0.4 4.7e-14 Response to anti-depressant treatment in major depressive disorder; CRC cis rs812925 0.533 rs35507645 chr2:61396766 A/G cg10580144 chr2:61372316 C2orf74 0.35 7.81 0.4 7.58e-14 Immature fraction of reticulocytes; CRC cis rs11122272 0.735 rs2790886 chr1:231529491 A/C cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.58 -8.75 -0.43 1.1e-16 Hemoglobin concentration; CRC cis rs11971779 0.680 rs11980313 chr7:139034643 C/G cg23387468 chr7:139079360 LUC7L2 0.41 7.14 0.37 6.12e-12 Diisocyanate-induced asthma; CRC trans rs12599106 0.792 rs12597352 chr16:34638507 A/T cg03395511 chr6:291903 DUSP22 -0.5 -6.85 -0.35 3.75e-11 Menopause (age at onset); CRC cis rs6504622 0.818 rs3851784 chr17:45040117 C/T cg16759221 chr17:45003025 GOSR2 -0.5 -7.66 -0.39 2.15e-13 Orofacial clefts; CRC cis rs875971 0.545 rs1638724 chr7:66040481 A/G cg18876405 chr7:65276391 NA -0.46 -6.34 -0.33 7.55e-10 Aortic root size; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg06185924 chr10:27529785 ACBD5 0.41 6.87 0.35 3.13e-11 Liver disease severity in Alagille syndrome; CRC cis rs7246657 0.943 rs7259968 chr19:37811854 T/C cg23950597 chr19:37808831 NA -0.48 -5.69 -0.3 2.75e-8 Coronary artery calcification; CRC cis rs2404602 0.716 rs8030411 chr15:76699855 A/G cg22467129 chr15:76604101 ETFA -0.39 -6.37 -0.33 6.47e-10 Blood metabolite levels; CRC cis rs172166 0.694 rs188105 chr6:28071393 C/T cg02683197 chr6:28174875 NA 0.67 9.18 0.45 4.91e-18 Cardiac Troponin-T levels; CRC cis rs1448094 0.512 rs12309296 chr12:86241566 T/C cg18827107 chr12:86230957 RASSF9 -0.45 -7.42 -0.38 9.97e-13 Major depressive disorder; CRC cis rs2739330 0.796 rs2154594 chr22:24254055 A/G cg16132339 chr22:24313637 DDTL;DDT -0.6 -9.78 -0.47 5.4e-20 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs11212617 1.000 rs660429 chr11:108181511 A/C cg14761454 chr11:108092087 ATM;NPAT 0.43 6.4 0.33 5.41e-10 Response to metformin in type 2 diabetes (glycemic); CRC cis rs10256972 0.591 rs11766651 chr7:1161646 A/G cg09177884 chr7:1199841 ZFAND2A -0.46 -6.6 -0.34 1.66e-10 Longevity;Endometriosis; CRC cis rs1878931 0.580 rs3848355 chr16:3407489 A/C cg26668626 chr16:3451006 ZNF174;ZNF434 0.88 14.38 0.62 1.03e-36 Body mass index (adult); CRC cis rs9296095 0.607 rs10947409 chr6:33515191 G/C cg14003231 chr6:33640908 ITPR3 0.46 7.01 0.36 1.36e-11 Platelet count; CRC cis rs34526934 0.608 rs7606110 chr2:177028551 T/C cg03152288 chr2:177042942 NA -0.57 -7.34 -0.38 1.71e-12 Obstructive sleep apnea trait (apnea hypopnea index); CRC trans rs7618501 1.000 rs11130221 chr3:49819102 C/G cg21665057 chr3:196295764 WDR53;FBXO45 0.86 15.78 0.66 3.78e-42 Intelligence (multi-trait analysis); CRC cis rs9462027 0.606 rs2744959 chr6:34616654 T/A cg07306190 chr6:34760872 UHRF1BP1 -0.35 -6.29 -0.33 1.01e-9 Systemic lupus erythematosus; CRC cis rs1799949 1.000 rs34942571 chr17:41273379 G/C cg23758822 chr17:41437982 NA 0.8 13.37 0.59 7.61e-33 Menopause (age at onset); CRC cis rs9443645 0.901 rs9352666 chr6:79572184 C/G cg11833968 chr6:79620685 NA -0.35 -6.15 -0.32 2.2e-9 Intelligence (multi-trait analysis); CRC cis rs798554 0.567 rs1182191 chr7:2869364 A/T cg13628971 chr7:2884303 GNA12 0.39 6.08 0.32 3.3e-9 Height; CRC cis rs4523957 0.928 rs216220 chr17:2148821 G/T cg16513277 chr17:2031491 SMG6 0.52 8.74 0.43 1.18e-16 Autism spectrum disorder or schizophrenia;Schizophrenia; CRC trans rs1005277 0.579 rs932538 chr10:38381314 T/C cg27523141 chr10:43048294 ZNF37B 0.49 7.37 0.38 1.35e-12 Extrinsic epigenetic age acceleration; CRC cis rs3617 0.539 rs11922975 chr3:52936763 C/T cg11645453 chr3:52864694 ITIH4 -0.36 -6.72 -0.35 7.94e-11 Red blood cell count;Autism spectrum disorder or schizophrenia; CRC cis rs1843834 0.505 rs940317 chr2:225358118 C/T cg22455342 chr2:225449267 CUL3 0.65 8.52 0.43 5.72e-16 IgE levels in asthmatics (D.p. specific); CRC cis rs1003719 0.788 rs11911508 chr21:38470504 T/C cg10648535 chr21:38446584 PIGP;TTC3 0.52 7.36 0.38 1.47e-12 Eye color traits; CRC cis rs67311347 1.000 rs4973998 chr3:40460352 C/T cg24209194 chr3:40518798 ZNF619 0.42 6.07 0.32 3.61e-9 Renal cell carcinoma; CRC cis rs877282 0.898 rs10904547 chr10:766283 C/T cg06581033 chr10:766294 NA -0.51 -5.61 -0.3 4.23e-8 Uric acid levels; CRC cis rs7666738 0.830 rs13122456 chr4:98936011 A/G cg17366294 chr4:99064904 C4orf37 0.43 7.32 0.37 1.95e-12 Colonoscopy-negative controls vs population controls; CRC trans rs12478296 1.000 rs59036157 chr2:243040228 C/A cg18288967 chr1:45987694 PRDX1 0.65 7.13 0.37 6.35e-12 Obesity-related traits; CRC cis rs10504229 0.683 rs55881798 chr8:58106406 T/C cg21724239 chr8:58056113 NA 0.52 6.99 0.36 1.5e-11 Developmental language disorder (linguistic errors); CRC cis rs769267 0.896 rs7253807 chr19:19631444 A/T cg01262667 chr19:19385393 TM6SF2 0.36 6.03 0.32 4.4e-9 Tonsillectomy; CRC trans rs629535 0.773 rs681534 chr8:70056964 A/C cg21567404 chr3:27674614 NA 0.93 15.84 0.66 2.1e-42 Dupuytren's disease; CRC cis rs400736 0.930 rs442862 chr1:8079494 T/C cg25007680 chr1:8021821 PARK7 0.54 7.67 0.39 1.99e-13 Response to antidepressants and depression; CRC cis rs12216125 0.537 rs12207059 chr6:25922385 C/T cg16482183 chr6:26056742 HIST1H1C 1.02 12.44 0.57 2.13e-29 Iron status biomarkers; CRC cis rs2841277 0.738 rs1036713 chr14:105396693 C/G cg15352829 chr14:105391018 PLD4 0.51 10.74 0.51 2.85e-23 Rheumatoid arthritis; CRC cis rs4665809 0.590 rs2289019 chr2:26420809 G/C cg22920501 chr2:26401640 FAM59B -0.82 -11.68 -0.54 1.37e-26 Gut microbiome composition (summer); CRC cis rs7428 0.545 rs1053561 chr2:85546052 A/G cg24342717 chr2:85555507 TGOLN2 -0.72 -11.91 -0.55 1.97e-27 Ear protrusion; CRC cis rs10504229 1.000 rs72650899 chr8:58180525 G/T cg01721255 chr8:58191610 C8orf71 0.49 6.17 0.32 2e-9 Developmental language disorder (linguistic errors); CRC cis rs10782582 0.609 rs5745543 chr1:76365111 A/T cg10523679 chr1:76189770 ACADM -0.4 -5.64 -0.3 3.59e-8 Daytime sleep phenotypes; CRC cis rs56283067 0.847 rs10807302 chr6:44710152 G/C cg18551225 chr6:44695536 NA -0.4 -5.72 -0.3 2.42e-8 Total body bone mineral density; CRC cis rs3617 0.625 rs2239548 chr3:52854186 A/C cg15147215 chr3:52552868 STAB1 -0.53 -9.26 -0.45 2.7e-18 Red blood cell count;Autism spectrum disorder or schizophrenia; CRC cis rs28493229 0.708 rs80003555 chr19:41160612 C/G cg21869046 chr19:41225005 ITPKC 0.41 6.19 0.32 1.81e-9 Kawasaki disease; CRC cis rs9486719 1.000 rs2142653 chr6:96871520 C/A cg06623918 chr6:96969491 KIAA0776 0.81 9.51 0.46 4.17e-19 Migraine;Coronary artery disease; CRC cis rs2019137 0.868 rs3748916 chr2:113984033 C/T cg21610815 chr2:113994035 PAX8;LOC654433;LOC440839 -0.45 -6.38 -0.33 5.96e-10 Lymphocyte counts; CRC cis rs1448094 0.817 rs11117115 chr12:86331021 A/G cg18827107 chr12:86230957 RASSF9 -0.42 -6.62 -0.34 1.48e-10 Major depressive disorder; CRC trans rs783540 0.846 rs783534 chr15:83250243 C/T cg18393722 chr15:85113863 UBE2QP1 -0.36 -6.31 -0.33 9.14e-10 Schizophrenia; CRC cis rs208520 0.661 rs4710566 chr6:66848538 G/A cg07460842 chr6:66804631 NA -1.09 -14.83 -0.63 1.79e-38 Exhaled nitric oxide output; CRC cis rs7618501 0.521 rs868891 chr3:49949071 A/G cg24110177 chr3:50126178 RBM5 -0.55 -8.12 -0.41 9.62e-15 Intelligence (multi-trait analysis); CRC cis rs6952808 0.723 rs4721295 chr7:2036669 G/T cg22963979 chr7:1858916 MAD1L1 0.51 7.67 0.39 1.97e-13 Bipolar disorder and schizophrenia; CRC cis rs3087591 0.960 rs2905803 chr17:29520056 T/C cg24425628 chr17:29625626 OMG;NF1 0.83 15.7 0.65 7.76e-42 Hip circumference; CRC cis rs13064411 0.542 rs1463643 chr3:113215447 A/G cg18753928 chr3:113234510 CCDC52 -0.53 -8.2 -0.41 5.32e-15 Response to simvastatin treatment (PCSK9 protein level change); CRC trans rs11098499 0.909 rs73842633 chr4:120375464 G/A cg25214090 chr10:38739885 LOC399744 0.66 10.37 0.5 5.35e-22 Corneal astigmatism; CRC cis rs2976388 0.609 rs2717605 chr8:143801015 T/G cg24046110 chr8:143859143 LYNX1 0.45 7.75 0.39 1.14e-13 Urinary tract infection frequency; CRC cis rs734999 0.588 rs11585048 chr1:2534087 C/T cg20673091 chr1:2541236 MMEL1 0.37 5.91 0.31 8.76e-9 Ulcerative colitis; CRC cis rs4713118 0.662 rs175954 chr6:28011585 A/G cg15786705 chr6:28176104 NA 0.7 9.88 0.48 2.51e-20 Parkinson's disease; CRC cis rs6502050 0.842 rs62079996 chr17:80076862 A/G cg09264619 chr17:80180166 NA 0.36 5.92 0.31 8.22e-9 Life satisfaction; CRC cis rs9435341 0.965 rs6669831 chr1:107608607 G/A cg11070056 chr1:107600091 PRMT6 -0.4 -6.11 -0.32 2.74e-9 Facial morphology (factor 21, depth of nasal alae); CRC trans rs2303319 0.504 rs62188988 chr2:162531068 T/C cg23247704 chr1:116518985 SLC22A15 -0.72 -6.18 -0.32 1.88e-9 Cognitive function; CRC cis rs11148252 0.875 rs7987115 chr13:52962097 C/T cg02158880 chr13:53174818 NA 0.41 6.15 0.32 2.22e-9 Lewy body disease; CRC cis rs910316 1.000 rs10142865 chr14:75555624 G/A cg03030879 chr14:75389066 RPS6KL1 -0.46 -7.33 -0.37 1.8e-12 Height; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg00812502 chr22:19109875 DGCR2 0.48 6.64 0.34 1.28e-10 Anxiety disorder; CRC cis rs9649213 0.555 rs6956686 chr7:97997945 T/C cg08684580 chr7:98029266 BAIAP2L1 -0.32 -5.63 -0.3 3.84e-8 Prostate cancer (SNP x SNP interaction); CRC cis rs977987 0.815 rs11149818 chr16:75419373 G/A cg03315344 chr16:75512273 CHST6 0.52 8.8 0.44 7.8e-17 Dupuytren's disease; CRC cis rs875971 1.000 rs1968225 chr7:65874773 T/C cg11764359 chr7:65958608 NA 0.61 9.95 0.48 1.41e-20 Aortic root size; CRC cis rs34526934 0.608 rs34720456 chr2:177027292 G/A cg26754761 chr2:177040938 NA -0.44 -6.62 -0.34 1.46e-10 Obstructive sleep apnea trait (apnea hypopnea index); CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg15216925 chr5:179921655 CNOT6 0.38 6.36 0.33 6.83e-10 Obesity-related traits; CRC cis rs7894051 0.681 rs2185747 chr10:135191460 T/G cg20534287 chr10:135191450 PAOX -0.88 -7.75 -0.39 1.14e-13 Lifespan; CRC cis rs28386778 0.863 rs8076760 chr17:61920497 T/C cg06873352 chr17:61820015 STRADA 0.76 14.12 0.61 1.01e-35 Prudent dietary pattern; CRC cis rs10503871 1.000 rs10503871 chr8:30436852 A/G cg26383811 chr8:30366931 RBPMS -0.4 -6.52 -0.34 2.61e-10 Metabolite levels (X-11787); CRC cis rs853679 0.517 rs868987 chr6:28110148 A/G cg12273811 chr6:28175739 NA -0.72 -9.22 -0.45 3.59e-18 Depression; CRC cis rs1691799 0.867 rs1495497 chr12:66770020 A/T cg16791601 chr12:66731901 HELB -0.66 -11.12 -0.52 1.31e-24 White blood cell count (basophil); CRC cis rs10504229 1.000 rs58053450 chr8:58173348 T/C cg02290350 chr8:58132656 NA -0.42 -5.96 -0.31 6.62e-9 Developmental language disorder (linguistic errors); CRC cis rs9611565 0.649 rs202645 chr22:41798520 A/G cg06634786 chr22:41940651 POLR3H 0.7 7.82 0.4 7.38e-14 Vitiligo; CRC cis rs9399135 1.000 rs35123050 chr6:135302740 G/A cg24558204 chr6:135376177 HBS1L 0.48 7.37 0.38 1.42e-12 Red blood cell count; CRC cis rs1555895 0.633 rs7913077 chr10:845969 T/C cg10556349 chr10:835070 NA -0.39 -7.6 -0.39 3.03e-13 Survival in rectal cancer; CRC cis rs9611565 0.512 rs139562 chr22:42196684 G/C cg17554472 chr22:41940697 POLR3H -0.56 -5.76 -0.3 1.93e-8 Vitiligo; CRC trans rs2303319 0.504 rs12476631 chr2:162566936 A/G cg18122310 chr12:50236657 BCDIN3D -0.73 -6.15 -0.32 2.25e-9 Cognitive function; CRC cis rs870825 0.929 rs72689265 chr4:185590982 A/G cg07424746 chr4:185654737 MLF1IP -0.59 -5.82 -0.31 1.4e-8 Blood protein levels; CRC cis rs6502050 0.835 rs7219138 chr17:80079896 C/T cg22110888 chr17:80059540 CCDC57 -0.41 -6.38 -0.33 6.13e-10 Life satisfaction; CRC cis rs875971 0.964 rs160635 chr7:65528918 T/C cg18912574 chr7:65842487 NCRNA00174 0.4 6.88 0.35 2.94e-11 Aortic root size; CRC cis rs769267 0.895 rs2916074 chr19:19530270 C/T cg03709012 chr19:19516395 GATAD2A 0.73 11.58 0.54 3.04e-26 Tonsillectomy; CRC cis rs367615 0.704 rs4320313 chr5:108828687 A/G cg17395555 chr5:108820864 NA 0.45 9.12 0.45 7.39e-18 Colorectal cancer (SNP x SNP interaction); CRC cis rs4662945 0.525 rs28625431 chr2:130303333 A/G cg05962382 chr2:130345044 NA -0.45 -7.69 -0.39 1.69e-13 Response to cytidine analogues (gemcitabine); CRC cis rs11785400 1.000 rs3735999 chr8:143746069 T/C cg10596483 chr8:143751796 JRK 0.49 6.92 0.36 2.35e-11 Schizophrenia; CRC cis rs9527 0.590 rs10883830 chr10:104851285 G/A cg04362960 chr10:104952993 NT5C2 0.62 8.69 0.43 1.73e-16 Arsenic metabolism; CRC cis rs9291683 0.526 rs12506122 chr4:10033538 C/A cg11266682 chr4:10021025 SLC2A9 0.52 10.52 0.5 1.61e-22 Bone mineral density; CRC cis rs9399137 0.507 rs6918512 chr6:135284839 T/G cg22676075 chr6:135203613 NA 0.58 8.76 0.43 1.03e-16 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; CRC cis rs4563143 0.577 rs73025093 chr19:29254618 T/G cg12756686 chr19:29218302 NA 0.62 9.36 0.46 1.27e-18 Methadone dose in opioid dependence; CRC trans rs7800418 0.817 rs882541 chr7:26590298 C/T cg14387656 chr2:233470847 EFHD1 0.45 6.07 0.32 3.58e-9 Cognitive function; CRC cis rs7584330 0.657 rs10202292 chr2:238352185 A/T cg11271282 chr2:238384023 NA 0.45 5.7 0.3 2.72e-8 Prostate cancer; CRC cis rs9372498 0.536 rs12333080 chr6:118845410 A/C cg01339444 chr6:118972232 C6orf204 0.53 6.0 0.31 5.22e-9 Diastolic blood pressure; CRC cis rs7712401 0.791 rs4835897 chr5:122121504 C/G cg18764291 chr5:122110994 SNX2 0.4 6.46 0.34 3.87e-10 Mean platelet volume; CRC cis rs2811415 0.597 rs12695503 chr3:127769174 C/A cg13719885 chr3:127795394 NA -0.37 -5.69 -0.3 2.76e-8 Lung function (FEV1/FVC); CRC cis rs4843747 0.641 rs11117353 chr16:88090895 A/G cg03395651 chr16:88107091 BANP 0.57 7.37 0.38 1.39e-12 Menopause (age at onset); CRC cis rs4750440 0.735 rs2447014 chr10:14010122 C/T cg00551146 chr10:14014579 FRMD4A -0.41 -6.71 -0.35 8.38e-11 Adiponectin levels; CRC cis rs34779708 0.931 rs11597483 chr10:35285117 A/G cg03585969 chr10:35415529 CREM 0.66 8.78 0.44 9.07e-17 Inflammatory bowel disease;Crohn's disease; CRC cis rs992157 0.835 rs6707559 chr2:219142773 C/T cg04731861 chr2:219085781 ARPC2 -0.32 -6.81 -0.35 4.61e-11 Colorectal cancer; CRC cis rs3820068 0.581 rs56128111 chr1:15928948 T/G cg27534772 chr1:16042836 PLEKHM2 0.54 10.46 0.5 2.7e-22 Systolic blood pressure; CRC cis rs7762018 0.891 rs1981069 chr6:170148837 G/A cg17545662 chr6:170176663 C6orf70 0.57 6.45 0.34 3.99e-10 Thiazide-induced adverse metabolic effects in hypertensive patients; CRC cis rs3741151 0.773 rs57673166 chr11:73232557 T/A cg17517138 chr11:73019481 ARHGEF17 0.98 8.0 0.4 2.12e-14 GIP levels in response to oral glucose tolerance test (120 minutes); CRC cis rs954108 0.809 rs1592060 chr13:29368944 T/C cg11788234 chr13:29393811 NA -0.42 -6.6 -0.34 1.64e-10 Obesity-related traits; CRC cis rs17270561 0.609 rs1937131 chr6:25744831 A/T cg17691542 chr6:26056736 HIST1H1C -0.74 -9.19 -0.45 4.48e-18 Iron status biomarkers; CRC cis rs2739330 0.791 rs4822458 chr22:24265659 C/T cg24846343 chr22:24311635 DDTL 0.72 12.06 0.55 5.55e-28 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs73200209 0.744 rs58471589 chr12:116573035 A/C cg01776926 chr12:116560359 MED13L -0.61 -7.06 -0.36 9.8e-12 Total body bone mineral density; CRC cis rs9814567 1.000 rs2370642 chr3:134222136 C/T cg06541857 chr3:134203789 ANAPC13;CEP63 -0.4 -6.01 -0.31 4.88e-9 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs1707322 0.896 rs785512 chr1:46534543 A/G cg03146154 chr1:46216737 IPP -0.52 -7.03 -0.36 1.19e-11 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg24536114 chr1:89448405 RBMXL1;CCBL2 -0.4 -6.28 -0.33 1.05e-9 Liver disease severity in Alagille syndrome; CRC cis rs1387259 0.929 rs2956703 chr12:48670294 C/T cg24011408 chr12:48396354 COL2A1 0.45 6.32 0.33 8.27e-10 Obstructive sleep apnea trait (apnea hypopnea index); CRC cis rs4237845 0.967 rs4553410 chr12:58301211 G/A cg02175503 chr12:58329896 NA 0.6 8.95 0.44 2.6e-17 Intelligence (multi-trait analysis); CRC cis rs7666738 0.830 rs1349757 chr4:99058763 C/G cg17366294 chr4:99064904 C4orf37 0.44 7.36 0.38 1.44e-12 Colonoscopy-negative controls vs population controls; CRC cis rs9611565 0.765 rs132920 chr22:41810170 T/C cg06634786 chr22:41940651 POLR3H 0.62 7.16 0.37 5.44e-12 Vitiligo; CRC cis rs9368481 0.524 rs12530345 chr6:26884243 T/C cg18867708 chr6:26865862 GUSBL1 0.42 6.14 0.32 2.39e-9 Autism spectrum disorder or schizophrenia; CRC cis rs17234274 0.644 rs10833964 chr11:23214853 A/T cg05245346 chr11:23248277 NA 0.36 5.93 0.31 7.53e-9 Cancer; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg08798492 chr16:3070269 TNFRSF12A 0.44 7.81 0.4 7.81e-14 Liver disease severity in Alagille syndrome; CRC cis rs763014 1.000 rs763014 chr16:675680 T/C cg04497992 chr16:616212 NHLRC4 0.43 6.7 0.35 8.91e-11 Height; CRC cis rs1215050 0.791 rs1648546 chr4:98899294 T/C cg05340658 chr4:99064831 C4orf37 -0.48 -7.09 -0.36 8.08e-12 Waist-to-hip ratio adjusted for body mass index; CRC cis rs13315871 1.000 rs13317400 chr3:58408792 T/G cg20936604 chr3:58311152 NA -0.75 -7.12 -0.37 6.99e-12 Cholesterol, total; CRC cis rs2841277 0.708 rs9671643 chr14:105408030 A/G cg15352829 chr14:105391018 PLD4 -0.49 -10.75 -0.51 2.71e-23 Rheumatoid arthritis; CRC cis rs853679 0.517 rs9393896 chr6:28127703 C/T cg25164649 chr6:28176230 NA 0.78 9.66 0.47 1.33e-19 Depression; CRC cis rs16852403 0.583 rs4440820 chr1:178088698 T/C cg00404053 chr1:178313656 RASAL2 0.6 7.71 0.39 1.48e-13 Childhood ear infection; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg15716185 chr18:60190644 ZCCHC2 0.46 6.22 0.32 1.5e-9 Thyroid stimulating hormone; CRC cis rs11758351 0.588 rs2050948 chr6:26234952 A/G cg08260959 chr6:26240920 HIST1H4F -0.35 -5.73 -0.3 2.24e-8 Gout;Renal underexcretion gout; CRC cis rs1862618 0.853 rs252887 chr5:56166188 A/G cg22800045 chr5:56110881 MAP3K1 0.61 6.6 0.34 1.6e-10 Initial pursuit acceleration; CRC cis rs265548 0.646 rs36689 chr19:17910639 A/G cg21960279 chr19:17905606 B3GNT3 0.44 7.19 0.37 4.31e-12 Tumor biomarkers; CRC cis rs4853012 0.775 rs12465641 chr2:74337715 A/G cg01017244 chr2:74357527 NA -0.63 -8.43 -0.42 1.12e-15 Gestational age at birth (maternal effect); CRC cis rs10791097 0.694 rs876641 chr11:130752040 A/C cg12179176 chr11:130786555 SNX19 0.75 12.51 0.57 1.2e-29 Autism spectrum disorder or schizophrenia;Schizophrenia; CRC cis rs4474465 0.850 rs11237537 chr11:78248397 C/T cg27205649 chr11:78285834 NARS2 -0.46 -5.68 -0.3 3.02e-8 Alzheimer's disease (survival time); CRC cis rs11212617 0.967 rs172895 chr11:108265876 C/G cg14761454 chr11:108092087 ATM;NPAT 0.43 6.45 0.34 3.92e-10 Response to metformin in type 2 diabetes (glycemic); CRC trans rs10982213 0.830 rs2274163 chr9:117188714 C/T cg02670133 chr5:65440111 SFRS12 0.4 6.22 0.32 1.53e-9 Interleukin-6 levels; CRC cis rs9818758 0.545 rs55921200 chr3:49189316 T/C cg07636037 chr3:49044803 WDR6 -0.86 -6.08 -0.32 3.37e-9 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; CRC cis rs6502050 0.865 rs56193110 chr17:80151501 A/G cg22110888 chr17:80059540 CCDC57 0.4 6.32 0.33 8.64e-10 Life satisfaction; CRC cis rs12474201 0.832 rs4953419 chr2:46989869 T/G cg06386533 chr2:46925753 SOCS5 0.77 12.41 0.56 2.91e-29 Height; CRC cis rs17384381 1.000 rs12140170 chr1:85849723 G/A cg16011679 chr1:85725395 C1orf52 0.63 6.45 0.33 4.05e-10 Lobe attachment (rater-scored or self-reported); CRC cis rs3806843 0.576 rs246005 chr5:140339884 A/C cg19875535 chr5:140030758 IK 0.4 6.12 0.32 2.64e-9 Depressive symptoms (multi-trait analysis); CRC cis rs7811142 0.943 rs28660238 chr7:100023308 C/T cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.89 12.32 0.56 6.09e-29 Platelet count; CRC cis rs12681288 0.676 rs17740799 chr8:1014327 C/T cg15309053 chr8:964076 NA -0.41 -7.24 -0.37 3.2e-12 Schizophrenia; CRC trans rs8108034 1.000 rs39587 chr19:39806997 C/T cg26155979 chr10:105110866 PCGF6 -0.5 -6.15 -0.32 2.27e-9 Lung adenocarcinoma; CRC cis rs9925964 1.000 rs9925964 chr16:31129895 A/G cg10396673 chr16:31104726 VKORC1 0.34 5.62 0.3 4.05e-8 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs11122272 0.735 rs2739510 chr1:231526718 T/C cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.58 -8.56 -0.43 4.43e-16 Hemoglobin concentration; CRC cis rs7589728 0.563 rs4972044 chr2:88466196 T/C cg04511125 chr2:88470314 THNSL2 0.81 8.56 0.43 4.31e-16 Plasma clusterin levels; CRC trans rs10021731 0.718 rs7698790 chr4:115413803 C/T cg25927708 chr2:119603813 EN1 0.33 6.01 0.31 4.98e-9 Optic disc area; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg15133363 chr7:128096265 C7orf68 0.44 6.2 0.32 1.66e-9 Response to antipsychotic treatment; CRC cis rs3020333 0.653 rs851985 chr6:152020390 G/T cg22157087 chr6:152012887 ESR1 -0.5 -7.59 -0.39 3.23e-13 Total body bone mineral density; CRC cis rs7103648 1.000 rs7103648 chr11:47461783 A/G cg20307385 chr11:47447363 PSMC3 1.0 18.93 0.72 1.43e-54 Diastolic blood pressure;Systolic blood pressure; CRC cis rs10883723 0.775 rs2296579 chr10:104241375 A/G cg11453585 chr10:104263688 ACTR1A;SUFU 0.91 16.55 0.67 3.38e-45 Allergic disease (asthma, hay fever or eczema); CRC cis rs2153535 0.580 rs7755284 chr6:8457479 T/C cg21535247 chr6:8435926 SLC35B3 0.51 7.86 0.4 5.53e-14 Motion sickness; CRC cis rs56161922 0.749 rs3738469 chr1:207818422 G/A cg11752769 chr1:207818423 CR1L -0.57 -5.68 -0.3 2.96e-8 Response to paliperidone in schizophrenia (PANSS score);Response to paliperidone in schizophrenia (positive Marder score); CRC cis rs13191362 1.000 rs13207239 chr6:163008772 A/C cg21926612 chr6:163149169 PACRG;PARK2 0.78 10.76 0.51 2.5e-23 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs7124681 0.528 rs74608150 chr11:47696214 A/T cg20307385 chr11:47447363 PSMC3 0.47 6.91 0.36 2.59e-11 Body mass index (joint analysis main effects and physical activity interaction);Body mass index;Body mass index in physically active individuals; CRC cis rs875971 0.737 rs7803424 chr7:65880605 T/C cg11764359 chr7:65958608 NA 0.61 9.95 0.48 1.41e-20 Aortic root size; CRC cis rs7178572 0.633 rs12907746 chr15:77843326 A/G cg22256960 chr15:77711686 NA -0.65 -9.27 -0.46 2.47e-18 Type 2 diabetes; CRC cis rs4927850 1.000 rs10881563 chr3:195750225 A/G cg01181863 chr3:195395398 SDHAP2 -0.7 -9.88 -0.48 2.56e-20 Pancreatic cancer; CRC cis rs7804356 1.000 rs10486485 chr7:26900356 C/A cg03456212 chr7:26904342 SKAP2 -0.5 -5.74 -0.3 2.17e-8 Type 1 diabetes; CRC cis rs9300255 0.602 rs2695478 chr12:123689521 C/T cg00376283 chr12:123451042 ABCB9 0.58 6.84 0.35 3.9e-11 Neutrophil percentage of white cells; CRC cis rs4654899 0.931 rs4654727 chr1:21214735 C/T cg02927042 chr1:21476669 EIF4G3 0.41 6.5 0.34 3.06e-10 Superior frontal gyrus grey matter volume; CRC trans rs6550704 0.687 rs9865314 chr3:22634337 A/G cg01362921 chr17:5015082 ZNF232 -0.41 -6.01 -0.31 4.9e-9 Daytime sleep phenotypes; CRC cis rs10779751 0.632 rs2748876 chr1:11134157 T/G cg08854313 chr1:11322531 MTOR 0.58 7.55 0.38 4.25e-13 Body mass index; CRC cis rs1552244 0.938 rs9873794 chr3:10074153 T/G cg16606324 chr3:10149918 C3orf24 0.68 9.31 0.46 1.85e-18 Alzheimer's disease; CRC cis rs8067545 0.750 rs28666381 chr17:19984809 C/G cg13482628 chr17:19912719 NA 0.47 7.5 0.38 5.81e-13 Schizophrenia; CRC cis rs861020 0.771 rs1962735 chr1:210012102 A/G cg05527609 chr1:210001259 C1orf107 0.91 12.83 0.58 8.2e-31 Orofacial clefts; CRC cis rs853679 0.546 rs200954 chr6:27838764 C/G cg03623178 chr6:28175578 NA 0.78 6.65 0.34 1.22e-10 Depression; CRC cis rs9322817 0.902 rs963949 chr6:105174273 A/G cg02098413 chr6:105308735 HACE1 -0.37 -6.67 -0.35 1.09e-10 Thyroid stimulating hormone; CRC trans rs2303319 0.504 rs56009150 chr2:162598582 T/C cg22902534 chr3:183892754 AP2M1 -0.72 -6.24 -0.33 1.32e-9 Cognitive function; CRC cis rs2228479 0.850 rs62052212 chr16:89981960 G/A cg06656553 chr16:89960601 TCF25 -0.65 -5.89 -0.31 9.76e-9 Skin colour saturation; CRC cis rs1707322 0.827 rs6694302 chr1:46245645 A/T cg03146154 chr1:46216737 IPP 0.62 8.87 0.44 4.65e-17 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs2762353 0.779 rs9393672 chr6:25842605 T/G cg03517284 chr6:25882590 NA -0.44 -6.64 -0.34 1.29e-10 Blood metabolite levels; CRC cis rs9291683 0.585 rs12648479 chr4:10104571 G/A cg11266682 chr4:10021025 SLC2A9 -0.44 -8.96 -0.44 2.42e-17 Bone mineral density; CRC cis rs1577917 0.771 rs3812133 chr6:86354411 C/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.64 -7.33 -0.37 1.82e-12 Response to antipsychotic treatment; CRC cis rs6973256 0.897 rs1041621 chr7:133353965 A/G cg10665199 chr7:133106180 EXOC4 0.37 5.88 0.31 9.92e-9 Intelligence (multi-trait analysis); CRC cis rs3772130 0.962 rs9826473 chr3:121556219 C/T cg20356878 chr3:121714668 ILDR1 0.52 8.08 0.41 1.25e-14 Cognitive performance; CRC cis rs10971721 0.822 rs10971791 chr9:33920910 G/C cg13495928 chr9:33750294 PRSS3 0.56 5.97 0.31 6.15e-9 Body mass index; CRC cis rs73206853 0.563 rs74869743 chr12:111204031 T/C cg12870014 chr12:110450643 ANKRD13A 0.71 8.08 0.41 1.25e-14 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC cis rs1570884 0.536 rs1359541 chr13:50158939 A/G cg02321871 chr13:50159138 RCBTB1 -0.42 -6.08 -0.32 3.34e-9 Sum basophil neutrophil counts;Sum neutrophil eosinophil counts;Neutrophil count;Myeloid white cell count;Granulocyte count; CRC cis rs457287 1.000 rs7048839 chr9:4835444 T/G cg14182974 chr9:4791918 RCL1 0.43 6.51 0.34 2.75e-10 Platelet count; CRC cis rs8060686 0.920 rs12448923 chr16:67839128 C/T cg26727032 chr16:67993705 SLC12A4 -0.59 -7.12 -0.37 7.02e-12 HDL cholesterol;Metabolic syndrome; CRC cis rs6570726 0.935 rs407721 chr6:145871354 A/C cg05347473 chr6:146136440 FBXO30 0.39 6.19 0.32 1.79e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs9910055 0.762 rs1135215 chr17:42253519 T/C cg09913183 chr17:42254507 C17orf65;ASB16 0.61 8.83 0.44 6.18e-17 Total body bone mineral density; CRC trans rs9329221 0.527 rs4841351 chr8:10327367 G/A cg06636001 chr8:8085503 FLJ10661 -0.47 -6.92 -0.36 2.34e-11 Neuroticism; CRC cis rs4409675 0.576 rs10751725 chr1:28216191 A/C cg23691781 chr1:28212827 C1orf38 -0.34 -7.84 -0.4 6.33e-14 Corneal astigmatism; CRC cis rs2797160 0.967 rs6910786 chr6:126017141 A/T cg05901451 chr6:126070800 HEY2 0.39 6.06 0.32 3.66e-9 Endometrial cancer; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg01084379 chr5:179160712 MAML1 0.41 6.5 0.34 2.93e-10 Liver disease severity in Alagille syndrome; CRC cis rs780096 0.505 rs12475426 chr2:27599132 G/A cg02592271 chr2:27665507 KRTCAP3 -0.26 -6.0 -0.31 5.09e-9 Total body bone mineral density; CRC cis rs4900538 0.819 rs72700604 chr14:102882307 G/A cg18135206 chr14:102964638 TECPR2 -0.95 -17.32 -0.69 3.07e-48 Mean corpuscular volume;Mean corpuscular hemoglobin; CRC cis rs9463078 0.845 rs6458419 chr6:45085038 T/C cg25276700 chr6:44698697 NA -0.29 -6.81 -0.35 4.6e-11 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; CRC cis rs990171 1.000 rs990171 chr2:103086770 A/C cg03938978 chr2:103052716 IL18RAP 0.45 5.67 0.3 3.09e-8 Lymphocyte counts; CRC trans rs8002861 0.691 rs9525851 chr13:44402132 T/A cg17145862 chr1:211918768 LPGAT1 -0.49 -8.14 -0.41 8.12e-15 Leprosy; CRC trans rs6693295 0.729 rs10802325 chr1:246213454 C/A cg08881680 chr11:94965469 SESN3 0.49 6.02 0.31 4.7e-9 Migraine - clinic-based;Migraine with aura; CRC cis rs2739330 0.789 rs5760109 chr22:24252938 C/G cg24846343 chr22:24311635 DDTL 0.82 14.6 0.63 1.49e-37 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs1799949 0.930 rs3092987 chr17:41222723 T/C cg19454999 chr17:41278357 BRCA1;NBR2 0.53 8.12 0.41 9.2e-15 Menopause (age at onset); CRC cis rs6502050 0.698 rs67143649 chr17:80117772 C/G cg02741985 chr17:80059408 CCDC57 0.43 7.17 0.37 5.1e-12 Life satisfaction; CRC cis rs2721195 0.874 rs2721173 chr8:145744429 C/T cg26752003 chr8:145688521 CYHR1 -0.46 -7.7 -0.39 1.6e-13 Age at first birth; CRC cis rs6543140 0.929 rs7602207 chr2:103032366 C/G cg04239558 chr2:103089729 SLC9A4 0.37 6.39 0.33 5.69e-10 Blood protein levels; CRC cis rs7814319 0.933 rs13261690 chr8:97238661 C/A cg20787634 chr8:97240163 UQCRB -0.54 -9.55 -0.47 3.08e-19 Lung function (FVC); CRC cis rs6762 0.692 rs5030778 chr11:836008 T/C cg03116740 chr11:841335 TSPAN4;POLR2L -0.41 -6.9 -0.36 2.7e-11 Mean platelet volume; CRC cis rs10791323 0.604 rs2723605 chr11:133711241 C/G cg06766960 chr11:133703094 NA -0.33 -5.6 -0.3 4.44e-8 Childhood ear infection; CRC cis rs3862260 0.509 rs3795663 chr1:120165187 G/A cg16322792 chr1:120165303 ZNF697 0.47 8.16 0.41 7.34e-15 Systemic lupus erythematosus; CRC cis rs9916302 0.821 rs1966915 chr17:37425262 A/C cg07936489 chr17:37558343 FBXL20 -0.83 -12.83 -0.58 7.83e-31 Glomerular filtration rate (creatinine); CRC trans rs4332037 0.713 rs56093134 chr7:1973970 C/T cg11693508 chr17:37793320 STARD3 0.67 7.86 0.4 5.51e-14 Bipolar disorder; CRC trans rs1814175 0.645 rs4625470 chr11:49983769 T/C cg03929089 chr4:120376271 NA -0.91 -16.17 -0.67 1.06e-43 Height; CRC trans rs9858542 0.953 rs9859556 chr3:49455986 G/T cg21659725 chr3:3221576 CRBN -0.63 -8.55 -0.43 4.61e-16 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs10046574 0.908 rs28418917 chr7:135124905 T/C cg27474649 chr7:135195673 CNOT4 0.69 5.71 0.3 2.49e-8 Peripheral arterial disease (traffic-related air pollution interaction); CRC trans rs1656966 1.000 rs1656966 chr3:186466252 C/T cg05301818 chr8:125385252 TMEM65 0.4 5.97 0.31 6.17e-9 Myopia (pathological); CRC cis rs763014 1.000 rs763014 chr16:675680 T/C cg18653534 chr16:772142 FAM173A -0.37 -5.87 -0.31 1.06e-8 Height; CRC cis rs7107174 1.000 rs2292573 chr11:78053139 A/G cg02023728 chr11:77925099 USP35 0.48 8.19 0.41 5.74e-15 Testicular germ cell tumor; CRC cis rs7833986 0.501 rs2667983 chr8:56894087 T/G cg23139584 chr8:56987506 RPS20;SNORD54 0.79 11.35 0.53 2e-25 Height; CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg26856583 chr16:87425887 MAP1LC3B;FBXO31 -0.53 -6.6 -0.34 1.6e-10 Diisocyanate-induced asthma; CRC cis rs1570884 0.516 rs9526580 chr13:50164023 C/G cg08779649 chr13:50194554 NA -0.42 -8.78 -0.44 9.16e-17 Sum basophil neutrophil counts;Sum neutrophil eosinophil counts;Neutrophil count;Myeloid white cell count;Granulocyte count; CRC cis rs2075371 0.966 rs2544225 chr7:133995838 A/C cg11752832 chr7:134001865 SLC35B4 0.5 7.69 0.39 1.77e-13 Mean platelet volume; CRC cis rs908922 0.676 rs7550769 chr1:152531213 G/A cg09873164 chr1:152488093 CRCT1 0.36 6.16 0.32 2.14e-9 Hair morphology; CRC cis rs9303401 0.659 rs12940212 chr17:56674474 T/C cg10487724 chr17:56770010 TEX14;RAD51C 0.78 9.14 0.45 6.68e-18 Cognitive test performance; CRC cis rs600806 0.850 rs2140924 chr1:109935775 A/C cg23032129 chr1:109941072 SORT1 -0.27 -5.84 -0.31 1.24e-8 Intelligence (multi-trait analysis); CRC cis rs7945705 0.935 rs2653567 chr11:8889630 T/C cg00186954 chr11:8933980 ST5;C11orf17 -0.45 -7.21 -0.37 3.89e-12 Hemoglobin concentration; CRC cis rs910316 1.000 rs10149880 chr14:75633008 A/G cg11812906 chr14:75593930 NEK9 -0.64 -10.06 -0.49 6.19e-21 Height; CRC cis rs6988636 0.792 rs62521807 chr8:124163621 T/C cg27053337 chr8:124217698 FAM83A 0.41 5.63 0.3 3.93e-8 Urinary uromodulin levels; CRC cis rs875971 0.545 rs6979636 chr7:65741625 A/G cg05627663 chr7:65219948 SNORA22;CCT6P1 0.59 8.23 0.41 4.39e-15 Aortic root size; CRC cis rs4713118 0.869 rs7776351 chr6:27726731 A/G cg12273811 chr6:28175739 NA -0.51 -7.32 -0.37 1.95e-12 Parkinson's disease; CRC cis rs7843479 0.582 rs11779655 chr8:21794041 A/G cg17168535 chr8:21777572 XPO7 -0.67 -11.87 -0.55 2.65e-27 Mean corpuscular volume; CRC cis rs2288073 0.965 rs13387930 chr2:24414400 A/G cg06627628 chr2:24431161 ITSN2 -0.71 -9.87 -0.48 2.79e-20 Venous thromboembolism (SNP x SNP interaction); CRC cis rs2688608 0.592 rs10762563 chr10:75524802 C/A cg16540259 chr10:75572220 NDST2 0.38 6.13 0.32 2.54e-9 Inflammatory bowel disease; CRC cis rs7493 1.000 rs12026 chr7:95041016 G/C cg20119798 chr7:94954144 PON1 -0.49 -6.17 -0.32 2.01e-9 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs2243480 1.000 rs316327 chr7:65609201 G/T cg25985355 chr7:65971099 NA 0.51 6.02 0.32 4.65e-9 Diabetic kidney disease; CRC cis rs9486715 0.790 rs2971602 chr6:97022468 C/T cg18709589 chr6:96969512 KIAA0776 -0.5 -7.39 -0.38 1.25e-12 Headache; CRC cis rs6762 0.719 rs28655651 chr11:837121 G/C cg15787769 chr11:842744 TSPAN4;POLR2L -0.47 -6.76 -0.35 6.21e-11 Mean platelet volume; CRC cis rs875971 0.862 rs2088655 chr7:65795711 T/C cg11764359 chr7:65958608 NA -0.58 -8.58 -0.43 3.7e-16 Aortic root size; CRC cis rs612683 0.690 rs11166440 chr1:100808363 C/T cg06223162 chr1:101003688 GPR88 -0.36 -6.49 -0.34 3.21e-10 Breast cancer; CRC cis rs709400 0.832 rs10145755 chr14:104121984 C/T cg12935359 chr14:103987150 CKB -0.37 -6.14 -0.32 2.44e-9 Body mass index; CRC cis rs6933660 0.720 rs6914656 chr6:151753421 C/G cg14416726 chr6:151773293 C6orf211;RMND1 -0.62 -9.35 -0.46 1.34e-18 Menarche (age at onset); CRC cis rs9393692 0.905 rs6940237 chr6:26282322 T/C cg13736514 chr6:26305472 NA -0.62 -11.75 -0.54 7.66e-27 Educational attainment; CRC cis rs2243480 0.901 rs58207111 chr7:65486723 C/T cg12463550 chr7:65579703 CRCP 0.7 6.44 0.33 4.33e-10 Diabetic kidney disease; CRC cis rs372883 0.648 rs11088117 chr21:30737816 G/C cg08807101 chr21:30365312 RNF160 0.55 7.94 0.4 3.16e-14 Pancreatic cancer; CRC cis rs72772090 0.539 rs72773986 chr5:96159717 G/A cg17330273 chr5:96107758 CAST;ERAP1 -0.58 -5.66 -0.3 3.29e-8 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs2075371 0.933 rs1901214 chr7:133945108 C/T cg20476274 chr7:133979776 SLC35B4 -0.73 -12.78 -0.58 1.24e-30 Mean platelet volume; CRC cis rs9900062 0.586 rs6504249 chr17:62676149 A/G cg02598441 chr17:62777298 LOC146880 -0.53 -6.77 -0.35 5.81e-11 QT interval; CRC cis rs1843834 0.539 rs2068244 chr2:225440011 A/G cg22455342 chr2:225449267 CUL3 -0.65 -8.83 -0.44 6.24e-17 IgE levels in asthmatics (D.p. specific); CRC cis rs9733 0.596 rs6692960 chr1:150695965 G/A cg15448220 chr1:150897856 SETDB1 0.45 6.41 0.33 5.09e-10 Tonsillectomy; CRC cis rs12893668 0.572 rs11846404 chr14:104156108 C/G cg24130564 chr14:104152367 KLC1 -0.42 -5.6 -0.3 4.43e-8 Reticulocyte count; CRC cis rs2842992 0.830 rs1853259 chr6:160147441 A/G cg19482086 chr6:160211437 TCP1;MRPL18 -0.69 -8.7 -0.43 1.66e-16 Age-related macular degeneration (geographic atrophy); CRC cis rs8180040 0.654 rs62246451 chr3:47211632 C/T cg10298567 chr3:47292165 KIF9 0.4 6.25 0.33 1.3e-9 Colorectal cancer; CRC cis rs12023718 0.588 rs6674606 chr1:178599017 T/C cg00404053 chr1:178313656 RASAL2 0.59 7.07 0.36 9.37e-12 Obesity-related traits; CRC cis rs9303401 0.646 rs9303403 chr17:57219300 C/T cg02118635 chr17:56770003 RAD51C;TEX14 -0.44 -6.59 -0.34 1.71e-10 Cognitive test performance; CRC cis rs6754311 0.689 rs191079 chr2:136633771 T/C cg15123519 chr2:136567270 LCT -0.35 -6.75 -0.35 6.67e-11 Mosquito bite size; CRC trans rs1814175 0.538 rs1684260 chr11:49224231 G/A cg21153622 chr11:89784906 NA 0.4 6.49 0.34 3.14e-10 Height; CRC cis rs4713118 0.539 rs200967 chr6:27862127 A/G cg23161317 chr6:28129485 ZNF389 0.44 6.13 0.32 2.57e-9 Parkinson's disease; CRC cis rs116095464 0.558 rs7708515 chr5:234989 C/G cg22857025 chr5:266934 NA -1.2 -16.29 -0.67 3.63e-44 Breast cancer; CRC cis rs780096 0.526 rs75855890 chr2:27625005 G/T cg12648201 chr2:27665141 KRTCAP3 -0.32 -6.1 -0.32 2.97e-9 Total body bone mineral density; CRC trans rs1005277 0.579 rs2505257 chr10:38372664 A/G cg17830980 chr10:43048298 ZNF37B -0.6 -9.94 -0.48 1.61e-20 Extrinsic epigenetic age acceleration; CRC cis rs1348850 0.872 rs10165785 chr2:178293295 C/T cg02961200 chr2:178257176 LOC100130691;AGPS 0.61 8.95 0.44 2.75e-17 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs375066 0.870 rs7258418 chr19:44383083 G/C cg12072164 chr19:44306565 LYPD5 0.37 5.74 0.3 2.18e-8 Breast cancer; CRC cis rs523522 0.962 rs651627 chr12:121009198 C/T cg27279351 chr12:120934652 DYNLL1 0.74 10.67 0.51 5.16e-23 High light scatter reticulocyte count; CRC trans rs2228479 0.850 rs17233497 chr16:89815152 G/A cg24644049 chr4:85504048 CDS1 0.89 6.68 0.35 1.01e-10 Skin colour saturation; CRC cis rs875971 0.545 rs313830 chr7:65551931 T/C cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.6 -7.5 -0.38 5.82e-13 Aortic root size; CRC cis rs10504229 0.689 rs17801390 chr8:58054768 T/C cg21724239 chr8:58056113 NA 0.79 9.65 0.47 1.4e-19 Developmental language disorder (linguistic errors); CRC cis rs60871478 1.000 rs34761279 chr7:794471 A/G cg13798912 chr7:905769 UNC84A 0.54 6.18 0.32 1.93e-9 Cerebrospinal P-tau181p levels; CRC cis rs10504229 0.815 rs75577263 chr8:58188434 A/G cg05313129 chr8:58192883 C8orf71 -0.47 -6.99 -0.36 1.49e-11 Developmental language disorder (linguistic errors); CRC cis rs17125944 0.505 rs75194546 chr14:53212069 A/C cg00686598 chr14:53173677 PSMC6 1.24 11.46 0.53 8.41e-26 Alzheimer's disease (late onset); CRC trans rs9291683 0.585 rs12648479 chr4:10104571 G/A cg26043149 chr18:55253948 FECH -0.51 -8.09 -0.41 1.18e-14 Bone mineral density; CRC cis rs4319547 0.695 rs113841747 chr12:122886088 G/T cg05707623 chr12:122985044 ZCCHC8 0.78 9.74 0.47 7.53e-20 Body mass index; CRC trans rs6479874 0.510 rs2248908 chr10:52750665 C/T cg15483030 chr1:5935144 NPHP4 -0.69 -6.23 -0.32 1.43e-9 Migraine; CRC trans rs2727020 0.553 rs10839295 chr11:49527345 A/C cg03929089 chr4:120376271 NA -0.92 -17.17 -0.69 1.29e-47 Coronary artery disease; CRC trans rs747782 0.527 rs75915859 chr11:48232931 C/T cg27395922 chr11:50257633 LOC441601 0.49 6.11 0.32 2.8e-9 Intraocular pressure; CRC cis rs2731664 0.792 rs2630765 chr5:176876825 T/C cg23176889 chr5:176863531 GRK6 -0.74 -16.42 -0.67 1.09e-44 Intelligence (multi-trait analysis); CRC trans rs6956675 0.915 rs1608134 chr7:62653607 A/C cg01314568 chr7:57830625 NA -0.6 -8.97 -0.44 2.37e-17 Obesity-related traits; CRC cis rs9810259 0.522 rs9875338 chr3:12296469 A/G cg04748988 chr3:12329223 PPARG 0.4 6.1 0.32 3.05e-9 Platelet count; CRC cis rs2404602 0.583 rs3759853 chr15:76587777 C/T cg23625390 chr15:77176239 SCAPER 0.39 5.65 0.3 3.44e-8 Blood metabolite levels; CRC cis rs6087771 0.890 rs6089056 chr20:30325773 A/G cg13852791 chr20:30311386 BCL2L1 0.76 15.43 0.65 8.47e-41 Subcortical brain region volumes;Putamen volume; CRC cis rs34779708 0.931 rs17582416 chr10:35287650 A/C cg03585969 chr10:35415529 CREM 0.63 8.26 0.41 3.58e-15 Inflammatory bowel disease;Crohn's disease; CRC cis rs1401999 1.000 rs1533684 chr3:183635815 A/G cg01324343 chr3:183735012 ABCC5 0.81 14.36 0.62 1.19e-36 Anterior chamber depth; CRC cis rs9828933 0.938 rs3816157 chr3:63999322 G/A cg16258503 chr3:63850278 ATXN7;THOC7 -0.54 -6.07 -0.32 3.44e-9 Type 2 diabetes; CRC cis rs8180040 0.620 rs749511 chr3:47035735 A/C cg10298567 chr3:47292165 KIF9 0.39 6.19 0.32 1.81e-9 Colorectal cancer; CRC cis rs3096299 0.900 rs3114867 chr16:89428967 A/C cg01788221 chr16:89496183 ANKRD11 -0.42 -6.34 -0.33 7.49e-10 Multiple myeloma (IgH translocation); CRC cis rs611744 0.647 rs6981420 chr8:109266694 T/G cg21045802 chr8:109455806 TTC35 0.42 6.54 0.34 2.36e-10 Dupuytren's disease; CRC cis rs9649465 0.561 rs2429621 chr7:123430316 A/G cg03229431 chr7:123269106 ASB15 0.51 8.14 0.41 8.32e-15 Migraine; CRC cis rs2976388 0.609 rs1594999 chr8:143790574 G/A cg20041105 chr8:143859282 LYNX1 0.46 8.31 0.42 2.48e-15 Urinary tract infection frequency; CRC cis rs6665290 0.935 rs17600669 chr1:227201871 A/G cg10327440 chr1:227177885 CDC42BPA -1.03 -22.54 -0.78 1.1e-68 Myeloid white cell count; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg24170415 chr4:185747632 ACSL1 0.48 6.27 0.33 1.12e-9 Thyroid stimulating hormone; CRC cis rs10540 1.000 rs61876326 chr11:467368 A/G cg11503833 chr11:492997 NA 0.56 5.89 0.31 9.64e-9 Body mass index; CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg07025548 chr5:74632477 HMGCR 0.44 7.13 0.37 6.27e-12 Obesity-related traits; CRC cis rs514406 0.570 rs1332776 chr1:53189816 C/T cg25767906 chr1:53392781 SCP2 -0.36 -5.75 -0.3 2.05e-8 Monocyte count; CRC cis rs561341 0.941 rs17780080 chr17:30343146 G/A cg19193384 chr17:30244184 NA -0.65 -7.54 -0.38 4.67e-13 Hip circumference adjusted for BMI; CRC cis rs6804368 0.649 rs7647948 chr3:30760602 C/T cg06106510 chr3:30762233 NA 0.41 7.46 0.38 7.59e-13 Blood metabolite levels; CRC cis rs11212617 1.000 rs609261 chr11:108158134 T/C cg01991180 chr11:108092276 ATM;NPAT 0.41 5.97 0.31 6.04e-9 Response to metformin in type 2 diabetes (glycemic); CRC cis rs11673344 0.583 rs10421436 chr19:37885503 T/C cg11720556 chr19:37764088 NA -0.41 -5.85 -0.31 1.17e-8 Obesity-related traits; CRC trans rs1814175 0.654 rs1164676 chr11:49324868 T/C cg15704280 chr7:45808275 SEPT13 0.86 13.91 0.61 6.45e-35 Height; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg22015966 chr11:47198573 ARFGAP2 -0.37 -6.2 -0.32 1.7e-9 Myopia (pathological); CRC cis rs13108904 0.870 rs11727987 chr4:1261435 A/G cg05665937 chr4:1216051 CTBP1 0.4 5.87 0.31 1.08e-8 Obesity-related traits; CRC trans rs3942852 0.568 rs2904315 chr11:48109948 C/T cg15704280 chr7:45808275 SEPT13 0.66 9.38 0.46 1.12e-18 Acute lymphoblastic leukemia (childhood); CRC cis rs34172651 0.517 rs35560136 chr16:24788915 T/A cg06028605 chr16:24865363 SLC5A11 0.54 8.14 0.41 8.27e-15 Intelligence (multi-trait analysis); CRC cis rs2976388 0.609 rs2572908 chr8:143802636 A/G cg24046110 chr8:143859143 LYNX1 0.45 7.75 0.39 1.17e-13 Urinary tract infection frequency; CRC cis rs10791323 0.581 rs2723608 chr11:133710149 A/G cg06766960 chr11:133703094 NA -0.33 -5.6 -0.3 4.44e-8 Childhood ear infection; CRC trans rs783540 0.900 rs55924160 chr15:83282196 C/T cg18393722 chr15:85113863 UBE2QP1 -0.42 -7.39 -0.38 1.25e-12 Schizophrenia; CRC cis rs3785574 0.962 rs2727329 chr17:61924566 C/T cg06873352 chr17:61820015 STRADA 0.48 7.47 0.38 7.15e-13 Height; CRC cis rs13118159 0.872 rs4974604 chr4:1345798 T/C cg19318889 chr4:1322082 MAEA 0.39 5.85 0.31 1.17e-8 Longevity; CRC cis rs3789045 0.688 rs6668637 chr1:204452295 A/G cg17419461 chr1:204415978 PIK3C2B -0.61 -8.51 -0.42 6.26e-16 Educational attainment (college completion); CRC cis rs10256972 0.591 rs6968988 chr7:1169619 A/G cg03923535 chr7:1197113 ZFAND2A 0.68 10.26 0.49 1.31e-21 Longevity;Endometriosis; CRC cis rs801193 0.844 rs7779971 chr7:66161790 T/C cg25985355 chr7:65971099 NA -0.32 -5.62 -0.3 3.97e-8 Aortic root size; CRC cis rs13191362 1.000 rs67042566 chr6:163006541 A/T cg06582575 chr6:163149167 PACRG;PARK2 0.77 10.59 0.5 9.54e-23 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs62408225 1.000 rs1504215 chr6:91006227 G/A cg06866423 chr6:90926672 BACH2 0.5 8.12 0.41 9.66e-15 Eosinophil counts;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC cis rs7824557 0.564 rs2572399 chr8:11234520 A/G cg08071915 chr8:12219732 FAM66A 0.32 5.74 0.3 2.13e-8 Retinal vascular caliber; CRC cis rs769267 0.930 rs4808957 chr19:19567248 A/G cg03709012 chr19:19516395 GATAD2A 0.73 11.46 0.53 7.95e-26 Tonsillectomy; CRC trans rs4512344 0.509 rs2409784 chr8:11396856 G/T cg08975724 chr8:8085496 FLJ10661 -0.42 -6.24 -0.33 1.33e-9 Bone ultrasound measurement (broadband ultrasound attenuation); CRC cis rs4478858 0.709 rs937786 chr1:31857869 G/A cg00250761 chr1:31883323 NA 0.4 7.52 0.38 5.14e-13 Alcohol dependence; CRC cis rs597539 0.616 rs72945243 chr11:68633358 T/C cg21963583 chr11:68658836 MRPL21 0.58 10.65 0.51 6.08e-23 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs4711350 0.765 rs756138 chr6:33755711 G/C cg07979401 chr6:33739406 LEMD2 -0.46 -5.98 -0.31 5.7e-9 Schizophrenia; CRC cis rs853679 0.713 rs200991 chr6:27815494 A/C cg03623178 chr6:28175578 NA -0.67 -7.39 -0.38 1.23e-12 Depression; CRC trans rs783540 1.000 rs783540 chr15:83254708 C/T cg18393722 chr15:85113863 UBE2QP1 0.36 6.51 0.34 2.75e-10 Schizophrenia; CRC cis rs6860806 0.507 rs274572 chr5:131710917 T/G cg09877947 chr5:131593287 PDLIM4 -0.44 -7.17 -0.37 5.01e-12 Breast cancer; CRC cis rs651907 0.535 rs34743741 chr3:101532448 C/T cg11279151 chr3:101281821 RG9MTD1 -0.52 -6.89 -0.36 2.78e-11 Colorectal cancer; CRC trans rs7618501 0.521 rs55692411 chr3:49911155 G/A cg21659725 chr3:3221576 CRBN 0.53 7.86 0.4 5.62e-14 Intelligence (multi-trait analysis); CRC cis rs11098499 0.874 rs7661020 chr4:120106982 T/C cg09307838 chr4:120376055 NA 0.61 8.96 0.44 2.53e-17 Corneal astigmatism; CRC cis rs2836974 0.644 rs11088471 chr21:40699313 A/G cg11890956 chr21:40555474 PSMG1 -0.8 -12.38 -0.56 3.66e-29 Cognitive function; CRC cis rs9527 0.590 rs11191572 chr10:104893137 A/G cg15744005 chr10:104629667 AS3MT -0.31 -6.1 -0.32 3.03e-9 Arsenic metabolism; CRC cis rs1448094 0.556 rs11610627 chr12:86167752 C/T cg18827107 chr12:86230957 RASSF9 -0.41 -6.23 -0.32 1.42e-9 Major depressive disorder; CRC cis rs12824058 0.844 rs7956408 chr12:130807547 A/T cg11710851 chr12:130765858 NA -0.41 -5.77 -0.3 1.83e-8 Menopause (age at onset); CRC cis rs2404602 0.598 rs11634019 chr15:76634680 A/G cg23625390 chr15:77176239 SCAPER -0.68 -9.64 -0.47 1.54e-19 Blood metabolite levels; CRC cis rs8031584 0.505 rs2959036 chr15:31219742 T/G cg19680485 chr15:31195859 MTMR15 0.47 6.6 0.34 1.68e-10 Huntington's disease progression; CRC cis rs34172651 0.517 rs35560136 chr16:24788915 T/A cg02428538 chr16:24856791 SLC5A11 -0.6 -6.69 -0.35 9.64e-11 Intelligence (multi-trait analysis); CRC cis rs3859192 0.577 rs25645 chr17:38173143 G/A cg17467752 chr17:38218738 THRA -0.49 -7.11 -0.37 7.12e-12 White blood cell count; CRC cis rs1538970 0.851 rs2055145 chr1:45926495 C/G cg05343316 chr1:45956843 TESK2 0.71 9.89 0.48 2.3e-20 Platelet count; CRC cis rs2479724 1.000 rs2479724 chr6:41890982 T/C cg17623882 chr6:41773611 USP49 -0.52 -8.49 -0.42 7.22e-16 Menarche (age at onset); CRC cis rs7826238 0.720 rs12546760 chr8:8374836 A/G cg06636001 chr8:8085503 FLJ10661 -0.49 -7.25 -0.37 3.08e-12 Systolic blood pressure; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg22074242 chr16:4321640 TFAP4 0.42 5.98 0.31 5.68e-9 Intelligence (multi-trait analysis); CRC cis rs2832191 1.000 rs2832189 chr21:30487414 C/T cg08807101 chr21:30365312 RNF160 -0.62 -10.03 -0.48 7.68e-21 Dental caries; CRC cis rs6499255 0.951 rs11075728 chr16:69611582 A/G cg15192750 chr16:69999425 NA 0.59 7.79 0.39 8.66e-14 IgE levels; CRC cis rs17270561 0.609 rs1185976 chr6:25822363 A/G cg16482183 chr6:26056742 HIST1H1C -0.51 -7.12 -0.37 6.94e-12 Iron status biomarkers; CRC cis rs67340775 0.541 rs200968 chr6:27859568 T/C cg19041857 chr6:27730383 NA -0.62 -6.77 -0.35 6.1e-11 Lung cancer in ever smokers; CRC cis rs3820928 0.605 rs13410141 chr2:227805529 A/G cg11843606 chr2:227700838 RHBDD1 -0.47 -7.12 -0.37 6.9e-12 Pulmonary function; CRC cis rs10504229 0.639 rs56825757 chr8:58106469 A/G cg04204079 chr8:58130323 NA -0.46 -5.79 -0.3 1.67e-8 Developmental language disorder (linguistic errors); CRC cis rs7542091 0.704 rs1883331 chr1:210043483 A/G cg05527609 chr1:210001259 C1orf107 -0.44 -5.86 -0.31 1.15e-8 Monobrow; CRC trans rs916888 0.773 rs538628 chr17:44787313 G/C cg07870213 chr5:140052090 DND1 1.0 10.88 0.51 9.64e-24 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs801193 1.000 rs62466794 chr7:66191579 G/A cg00343986 chr7:65444356 GUSB 0.49 7.15 0.37 5.6e-12 Aortic root size; CRC cis rs1005277 0.557 rs176887 chr10:38406094 T/C cg00409905 chr10:38381863 ZNF37A -0.68 -11.31 -0.53 2.81e-25 Extrinsic epigenetic age acceleration; CRC cis rs6952808 0.782 rs4236271 chr7:1881369 C/T cg21782813 chr7:2030301 MAD1L1 0.38 6.73 0.35 7.42e-11 Bipolar disorder and schizophrenia; CRC cis rs9807989 0.801 rs6734742 chr2:102967857 C/T cg03938978 chr2:103052716 IL18RAP 0.37 5.96 0.31 6.47e-9 Asthma; CRC cis rs172166 0.694 rs203892 chr6:28067196 T/C cg12273811 chr6:28175739 NA 0.62 9.07 0.45 1.1e-17 Cardiac Troponin-T levels; CRC cis rs4253772 0.550 rs6007779 chr22:46678615 A/C cg03482458 chr22:46692211 CN5H6.4;GTSE1 0.58 8.21 0.41 5.23e-15 LDL cholesterol;Cholesterol, total; CRC cis rs2070677 0.708 rs12762259 chr10:135350365 C/T cg16964102 chr10:135390573 NA -0.49 -6.82 -0.35 4.41e-11 Gout; CRC cis rs870825 0.929 rs72689260 chr4:185590656 G/T cg07424746 chr4:185654737 MLF1IP -0.59 -5.82 -0.31 1.4e-8 Blood protein levels; CRC trans rs2303319 0.504 rs56145818 chr2:162403778 G/A cg09481857 chr22:21368659 P2RX6;MGC16703 -0.64 -6.1 -0.32 3.04e-9 Cognitive function; CRC cis rs853679 0.517 rs9393897 chr6:28127710 G/T cg23161317 chr6:28129485 ZNF389 0.53 6.43 0.33 4.52e-10 Depression; CRC cis rs853679 0.517 rs9357066 chr6:28129831 T/C cg18032046 chr6:28092343 ZSCAN16 -0.51 -5.93 -0.31 7.47e-9 Depression; CRC cis rs10779751 0.922 rs2746637 chr1:11275588 A/G cg08854313 chr1:11322531 MTOR 0.64 9.09 0.45 9.47e-18 Body mass index; CRC cis rs7659604 0.517 rs56311153 chr4:122729685 T/C cg23574427 chr4:122746245 BBS7;CCNA2 -0.3 -5.65 -0.3 3.39e-8 Type 2 diabetes; CRC trans rs3942852 0.955 rs1532754 chr11:48115279 A/T cg03929089 chr4:120376271 NA -0.58 -6.76 -0.35 6.34e-11 Acute lymphoblastic leukemia (childhood); CRC cis rs68170813 0.559 rs2395880 chr7:107074264 A/G cg23293999 chr7:106826042 HBP1 -0.49 -5.66 -0.3 3.33e-8 Coronary artery disease; CRC cis rs6121246 0.909 rs6060633 chr20:30263317 G/T cg07809909 chr20:30433512 FOXS1 0.35 5.7 0.3 2.6e-8 Mean corpuscular hemoglobin; CRC cis rs17155006 0.691 rs413412 chr7:107745399 A/G cg05962710 chr7:107745446 LAMB4 -0.41 -7.32 -0.37 1.93e-12 Pneumococcal bacteremia; CRC cis rs7119 0.717 rs12916682 chr15:77807937 A/T cg10437265 chr15:77819839 NA 0.64 11.52 0.54 4.83e-26 Type 2 diabetes; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg16572859 chr19:18263815 PIK3R2 0.38 6.03 0.32 4.43e-9 Liver disease severity in Alagille syndrome; CRC cis rs6500602 0.789 rs2404546 chr16:4479734 C/G cg14951292 chr16:4525986 HMOX2;NMRAL1 0.54 8.02 0.4 1.81e-14 Schizophrenia; CRC cis rs6582630 0.519 rs8189461 chr12:38374870 G/T cg26384229 chr12:38710491 ALG10B 0.69 9.77 0.47 5.95e-20 Drug-induced liver injury (flucloxacillin); CRC cis rs9457247 1.000 rs409356 chr6:167405226 T/A cg23791538 chr6:167370224 RNASET2 -0.38 -5.94 -0.31 7.32e-9 Crohn's disease; CRC cis rs9914988 0.943 rs11651867 chr17:27147248 T/G cg12682573 chr17:27188876 MIR451;MIR144 0.57 7.99 0.4 2.37e-14 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs769267 0.930 rs7254748 chr19:19397479 A/C cg01262667 chr19:19385393 TM6SF2 0.37 6.17 0.32 2.05e-9 Tonsillectomy; CRC trans rs1814175 0.616 rs4881723 chr11:49788566 G/T cg15704280 chr7:45808275 SEPT13 -0.96 -17.19 -0.69 1.03e-47 Height; CRC cis rs6879260 1.000 rs888922 chr5:179731635 C/G cg13944838 chr5:179740914 GFPT2 -0.72 -11.81 -0.55 4.67e-27 Height; CRC cis rs7617773 0.780 rs34589064 chr3:48339549 G/A cg11946769 chr3:48343235 NME6 0.73 9.93 0.48 1.73e-20 Coronary artery disease; CRC cis rs10804591 0.666 rs13079843 chr3:129308096 G/A cg21885638 chr3:129306552 PLXND1 0.4 5.96 0.31 6.41e-9 Waist-hip ratio;Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Hip circumference adjusted for BMI;Waist-to-hip ratio adjusted for body mass index; CRC cis rs6540556 0.723 rs1415542 chr1:209902110 T/C cg05527609 chr1:210001259 C1orf107 -0.56 -6.21 -0.32 1.56e-9 Red blood cell count; CRC cis rs6500602 1.000 rs6500602 chr16:4497451 T/C cg14951292 chr16:4525986 HMOX2;NMRAL1 0.58 8.55 0.43 4.74e-16 Schizophrenia; CRC cis rs75920871 0.528 rs1241655 chr11:116837808 G/T cg20608306 chr11:116969690 SIK3 -0.34 -6.57 -0.34 1.98e-10 Subjective well-being; CRC cis rs72634258 0.945 rs12727642 chr1:8046672 C/A cg00042356 chr1:8021962 PARK7 0.71 7.83 0.4 6.78e-14 Inflammatory bowel disease; CRC cis rs172166 0.694 rs203876 chr6:28046673 T/C cg02683197 chr6:28174875 NA 0.64 8.9 0.44 3.89e-17 Cardiac Troponin-T levels; CRC cis rs12476592 0.602 rs2592388 chr2:63896096 A/C cg10828910 chr2:63850056 LOC388955 0.52 6.44 0.33 4.3e-10 Childhood ear infection; CRC cis rs597539 0.652 rs686390 chr11:68656077 T/C cg21963583 chr11:68658836 MRPL21 0.64 11.34 0.53 2.24e-25 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs2404602 0.735 rs4886805 chr15:76739384 A/G cg23625390 chr15:77176239 SCAPER 0.82 12.72 0.57 2.09e-30 Blood metabolite levels; CRC cis rs926938 0.521 rs360649 chr1:115439668 G/C cg12756093 chr1:115239321 AMPD1 0.58 8.44 0.42 1.01e-15 Autism; CRC cis rs10504229 0.775 rs55825382 chr8:58157605 G/A cg11062466 chr8:58055876 NA 0.46 6.02 0.32 4.61e-9 Developmental language disorder (linguistic errors); CRC cis rs57221529 0.709 rs72706611 chr5:561146 C/A cg17948913 chr5:572064 NA 0.55 6.25 0.33 1.29e-9 Lung disease severity in cystic fibrosis; CRC cis rs422249 0.547 rs174537 chr11:61552680 G/T cg06781209 chr11:61594997 FADS2 -0.39 -5.73 -0.3 2.25e-8 Trans fatty acid levels; CRC cis rs2223471 0.754 rs2817361 chr6:50771563 C/T cg03432817 chr6:50765336 NA 0.43 6.93 0.36 2.24e-11 Subcutaneous adipose tissue; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg20566420 chr12:122327043 PSMD9 0.49 6.97 0.36 1.79e-11 Response to antipsychotic treatment; CRC cis rs3741404 0.537 rs1123251 chr11:63917601 G/T cg05016508 chr11:63871570 FLRT1;MACROD1 -0.38 -5.78 -0.3 1.72e-8 Platelet count; CRC cis rs775227 0.574 rs16861158 chr3:113261709 G/T cg18753928 chr3:113234510 CCDC52 -0.6 -7.07 -0.36 9.15e-12 Dental caries; CRC cis rs9308731 0.644 rs7577824 chr2:111876763 G/A cg04202892 chr2:111875749 ACOXL 0.43 6.89 0.36 2.84e-11 Chronic lymphocytic leukemia; CRC cis rs3540 0.960 rs11853271 chr15:91025830 C/T cg04176472 chr15:90893244 GABARAPL3 0.36 6.29 0.33 9.98e-10 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; CRC cis rs896854 0.738 rs1713669 chr8:95958637 C/G cg16049864 chr8:95962084 TP53INP1 -0.58 -9.16 -0.45 5.85e-18 Type 2 diabetes; CRC trans rs11165623 0.792 rs6671371 chr1:96977039 A/G cg10631902 chr5:14652156 NA -0.48 -8.78 -0.44 8.87e-17 Hip circumference;Waist circumference; CRC cis rs10751667 0.621 rs7394681 chr11:952111 C/T cg01483505 chr11:975446 AP2A2 0.45 7.39 0.38 1.21e-12 Alzheimer's disease (late onset); CRC cis rs6960043 1.000 rs62448644 chr7:15053485 C/T cg19272540 chr7:15055459 NA -0.23 -6.1 -0.32 2.94e-9 Type 2 diabetes; CRC cis rs1552244 0.872 rs35988239 chr3:10074145 G/T cg10729496 chr3:10149963 C3orf24 0.58 6.59 0.34 1.74e-10 Alzheimer's disease; CRC cis rs9443645 0.901 rs10943605 chr6:79655477 G/A cg05283184 chr6:79620031 NA -0.57 -9.14 -0.45 6.69e-18 Intelligence (multi-trait analysis); CRC cis rs11229555 1.000 rs2276153 chr11:58407740 C/G cg15696309 chr11:58395628 NA -0.95 -13.35 -0.59 8.39e-33 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; CRC cis rs2836974 0.831 rs11911149 chr21:40528375 C/T cg06238570 chr21:40685208 BRWD1 0.71 10.11 0.49 4.09e-21 Cognitive function; CRC cis rs9372498 0.505 rs62424204 chr6:118861642 G/A cg24463073 chr6:118973353 C6orf204 0.52 6.89 0.36 2.77e-11 Diastolic blood pressure; CRC cis rs1552244 0.554 rs2272121 chr3:10047680 A/G cg00166722 chr3:10149974 C3orf24 0.43 6.36 0.33 6.73e-10 Alzheimer's disease; CRC cis rs4713118 0.662 rs9380046 chr6:28030499 T/C cg12273811 chr6:28175739 NA 0.62 8.29 0.42 2.87e-15 Parkinson's disease; CRC cis rs7493 0.755 rs62467350 chr7:94970114 T/C cg19678392 chr7:94953810 PON1 -0.53 -6.67 -0.35 1.08e-10 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs875971 0.862 rs6460282 chr7:65691246 T/C cg11764359 chr7:65958608 NA -0.59 -8.78 -0.44 9.24e-17 Aortic root size; CRC cis rs6502050 0.731 rs76421195 chr17:80109326 T/C cg22110888 chr17:80059540 CCDC57 0.4 6.44 0.33 4.17e-10 Life satisfaction; CRC cis rs4332037 0.713 rs56093134 chr7:1973970 C/T cg24505167 chr7:1915268 MAD1L1 -0.44 -6.12 -0.32 2.72e-9 Bipolar disorder; CRC cis rs7727544 0.606 rs200838 chr5:131710399 A/C cg14196790 chr5:131705035 SLC22A5 -0.41 -7.34 -0.38 1.69e-12 Blood metabolite levels; CRC cis rs7044106 0.791 rs4836829 chr9:123482747 C/T cg09419670 chr9:123605666 PSMD5;LOC253039 0.77 12.4 0.56 3.13e-29 Hip circumference adjusted for BMI; CRC cis rs6570726 1.000 rs374464 chr6:145846679 A/C cg23711669 chr6:146136114 FBXO30 0.69 12.05 0.55 5.88e-28 Lobe attachment (rater-scored or self-reported); CRC cis rs2976388 1.000 rs2572910 chr8:143770135 C/G cg05569086 chr8:143859399 LYNX1 -0.34 -5.93 -0.31 7.5e-9 Urinary tract infection frequency; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg04718306 chr1:68151105 GADD45A 0.41 6.12 0.32 2.63e-9 Intelligence (multi-trait analysis); CRC cis rs637571 0.565 rs633800 chr11:65638719 G/A cg04055107 chr11:65626734 MUS81;CFL1 -0.42 -5.99 -0.31 5.44e-9 Eosinophil percentage of white cells; CRC cis rs10242455 0.702 rs59574285 chr7:99236151 C/T cg18809830 chr7:99032528 PTCD1 -1.04 -7.34 -0.38 1.68e-12 Blood metabolite levels; CRC cis rs75920871 0.528 rs3886960 chr11:116924990 G/T cg20608306 chr11:116969690 SIK3 -0.34 -6.46 -0.34 3.86e-10 Subjective well-being; CRC cis rs477895 0.653 rs7102327 chr11:63908720 C/T cg23719950 chr11:63933701 MACROD1 -0.63 -8.02 -0.4 1.91e-14 Mean platelet volume; CRC cis rs875971 0.660 rs1860470 chr7:66103694 G/C cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.43 -6.4 -0.33 5.21e-10 Aortic root size; CRC cis rs477895 0.713 rs11601024 chr11:63943074 A/G cg04317338 chr11:64019027 PLCB3 0.58 7.14 0.37 6.02e-12 Mean platelet volume; CRC cis rs7113874 0.569 rs10160430 chr11:8599876 G/T cg02811074 chr11:8615871 STK33 0.35 6.04 0.32 4.21e-9 Body mass index in physically active individuals;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs1881797 0.932 rs10925071 chr1:247686521 C/T cg21399703 chr1:247681439 NA -0.53 -9.84 -0.48 3.35e-20 Acute lymphoblastic leukemia (childhood); CRC trans rs800082 0.507 rs2222701 chr3:144258813 C/T cg24215973 chr2:240111563 HDAC4 0.44 6.19 0.32 1.82e-9 Smoking behavior; CRC cis rs11255291 0.668 rs4749169 chr10:7737661 G/C cg13340899 chr10:7670827 ITIH5 0.39 5.72 0.3 2.33e-8 Ovarian reserve; CRC trans rs35110281 0.565 rs7278003 chr21:44966069 T/C cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.53 8.71 0.43 1.49e-16 Mean corpuscular volume; CRC cis rs2153535 0.580 rs6597330 chr6:8492076 T/C cg21535247 chr6:8435926 SLC35B3 0.5 7.54 0.38 4.72e-13 Motion sickness; CRC cis rs11148252 0.514 rs3783242 chr13:52717950 C/T cg00495681 chr13:53174319 NA 0.56 8.05 0.41 1.54e-14 Lewy body disease; CRC cis rs6860806 0.507 rs2631364 chr5:131706914 C/G cg20512303 chr5:131592959 PDLIM4 -0.39 -6.69 -0.35 9.34e-11 Breast cancer; CRC cis rs860295 0.702 rs10796945 chr1:155427688 G/A cg02153340 chr1:155202674 NA -0.53 -7.01 -0.36 1.36e-11 Body mass index; CRC cis rs9393692 0.875 rs2142703 chr6:26289605 A/G cg05868516 chr6:26286170 HIST1H4H 0.39 5.72 0.3 2.41e-8 Educational attainment; CRC cis rs34172651 0.537 rs8049014 chr16:24698903 A/G cg00339695 chr16:24857497 SLC5A11 0.32 6.47 0.34 3.57e-10 Intelligence (multi-trait analysis); CRC trans rs783540 0.934 rs8043401 chr15:83356259 A/G cg18393722 chr15:85113863 UBE2QP1 0.36 6.24 0.33 1.36e-9 Schizophrenia; CRC cis rs4731207 0.596 rs1871771 chr7:124679051 G/A cg23710748 chr7:124431027 NA -0.39 -6.14 -0.32 2.35e-9 Cutaneous malignant melanoma; CRC cis rs9560113 0.960 rs61967677 chr13:112174044 A/G cg10483660 chr13:112241077 NA 0.35 5.65 0.3 3.57e-8 Menarche (age at onset); CRC cis rs4332037 0.762 rs11770612 chr7:1915493 A/C cg25834613 chr7:1915315 MAD1L1 -0.5 -7.85 -0.4 6.08e-14 Bipolar disorder; CRC cis rs4731207 0.698 rs2286173 chr7:124465951 A/C cg23710748 chr7:124431027 NA 0.37 5.93 0.31 7.72e-9 Cutaneous malignant melanoma; CRC cis rs765787 0.556 rs12915965 chr15:45512647 T/C cg24006582 chr15:45444508 DUOX1 0.52 7.52 0.38 5.41e-13 Uric acid levels; CRC cis rs6952808 0.792 rs2056481 chr7:1955435 A/G cg21782813 chr7:2030301 MAD1L1 0.49 8.46 0.42 8.76e-16 Bipolar disorder and schizophrenia; CRC cis rs11233250 0.528 rs58791004 chr11:82402167 C/T cg17391194 chr11:82401662 NA 0.44 6.73 0.35 7.69e-11 Glioblastoma;Glioma; CRC cis rs6951245 0.872 rs76161580 chr7:1100307 G/T cg18402987 chr7:1209562 NA 0.67 7.17 0.37 5.02e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg14533885 chr3:146262700 PLSCR1 0.4 6.01 0.31 4.79e-9 Liver disease severity in Alagille syndrome; CRC cis rs2408955 0.561 rs11168365 chr12:48421772 A/G cg15465823 chr12:48382534 COL2A1 -0.39 -6.34 -0.33 7.48e-10 Glycated hemoglobin levels; CRC cis rs6701037 1.000 rs6683533 chr1:175125440 G/A cg00321850 chr1:175162397 KIAA0040 -0.36 -5.87 -0.31 1.06e-8 Alcohol dependence; CRC cis rs10464366 0.544 rs12668821 chr7:39167846 T/A cg21665744 chr7:39171113 POU6F2 0.45 5.96 0.31 6.67e-9 IgG glycosylation; CRC cis rs6429082 0.715 rs9793740 chr1:235595590 T/C cg26050004 chr1:235667680 B3GALNT2 -0.47 -6.34 -0.33 7.66e-10 Adiposity; CRC cis rs12780046 0.536 rs1892507 chr10:101082348 G/A cg26459859 chr10:101118273 CNNM1 -0.46 -6.34 -0.33 7.68e-10 Non-glioblastoma glioma; CRC cis rs1862618 0.802 rs832547 chr5:56183941 C/G cg20203395 chr5:56204925 C5orf35 -0.72 -8.29 -0.42 2.99e-15 Initial pursuit acceleration; CRC cis rs4713118 0.955 rs9468200 chr6:27683063 T/A cg20933634 chr6:27740509 NA 0.56 7.74 0.39 1.26e-13 Parkinson's disease; CRC cis rs2739330 0.731 rs5751792 chr22:24401542 G/A cg11905131 chr22:24372483 LOC391322 -0.6 -9.38 -0.46 1.13e-18 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs7618915 0.501 rs13079063 chr3:52744460 A/G cg11645453 chr3:52864694 ITIH4 0.37 6.51 0.34 2.83e-10 Bipolar disorder; CRC cis rs881375 0.678 rs10118357 chr9:123680068 C/T cg09419670 chr9:123605666 PSMD5;LOC253039 0.51 8.2 0.41 5.31e-15 Rheumatoid arthritis; CRC trans rs11098499 0.575 rs907204 chr4:120238654 G/A cg25214090 chr10:38739885 LOC399744 0.53 8.45 0.42 9.68e-16 Corneal astigmatism; CRC cis rs9318086 0.712 rs9318100 chr13:24442482 A/G cg25267304 chr13:24462978 PCOTH;MIPEP -0.58 -9.41 -0.46 8.73e-19 Myopia (pathological); CRC cis rs9527 0.590 rs4917992 chr10:104786313 G/A cg04362960 chr10:104952993 NT5C2 0.6 8.36 0.42 1.79e-15 Arsenic metabolism; CRC cis rs6570726 0.846 rs6899900 chr6:145883873 T/G cg23711669 chr6:146136114 FBXO30 0.68 11.36 0.53 1.95e-25 Lobe attachment (rater-scored or self-reported); CRC cis rs10155981 0.510 rs4719705 chr7:22592707 C/T cg05062323 chr7:22590069 NA -0.56 -5.85 -0.31 1.16e-8 Bilirubin levels; CRC cis rs7503807 1.000 rs901064 chr17:78596040 C/T cg09596252 chr17:78655493 RPTOR -0.38 -5.77 -0.3 1.87e-8 Obesity; CRC cis rs262150 0.704 rs2730236 chr7:158765543 C/T cg04111992 chr7:158790115 NA -0.39 -6.36 -0.33 6.88e-10 Facial morphology (factor 20); CRC cis rs6598955 0.671 rs11247901 chr1:26612693 T/A cg00852783 chr1:26633632 UBXN11 -0.49 -5.81 -0.31 1.45e-8 Obesity-related traits; CRC cis rs12142240 0.698 rs72677594 chr1:46824371 A/C cg14993813 chr1:46806288 NSUN4 -0.49 -6.22 -0.32 1.55e-9 Menopause (age at onset); CRC cis rs1218582 0.741 rs4339857 chr1:154888962 A/G cg06221963 chr1:154839813 KCNN3 -0.77 -15.56 -0.65 2.56e-41 Prostate cancer; CRC cis rs514406 0.929 rs12145105 chr1:53340564 T/C cg24675658 chr1:53192096 ZYG11B -0.58 -8.5 -0.42 6.59e-16 Monocyte count; CRC cis rs4713118 0.621 rs9295755 chr6:28033174 C/T cg23161317 chr6:28129485 ZNF389 -0.48 -6.12 -0.32 2.63e-9 Parkinson's disease; CRC cis rs796364 1.000 rs35220450 chr2:200780737 T/C cg25936922 chr2:200820526 C2orf60;C2orf47 -0.77 -7.36 -0.38 1.51e-12 Schizophrenia; CRC cis rs1059312 0.808 rs12831705 chr12:129294905 G/A cg09035930 chr12:129282057 SLC15A4 0.52 8.66 0.43 2.13e-16 Systemic lupus erythematosus; CRC cis rs8177253 0.763 rs6797713 chr3:133474832 T/C cg24879335 chr3:133465180 TF 0.33 5.78 0.3 1.71e-8 Iron status biomarkers; CRC cis rs2732480 0.500 rs12829841 chr12:48628739 A/G cg24011408 chr12:48396354 COL2A1 0.46 6.35 0.33 7.23e-10 Hemoglobin concentration;Red blood cell count;Hematocrit; CRC cis rs6461049 0.765 rs3800908 chr7:2159437 C/T cg21782813 chr7:2030301 MAD1L1 0.44 8.0 0.4 2.16e-14 Schizophrenia; CRC cis rs10504229 0.683 rs72650847 chr8:58136825 C/T cg20607798 chr8:58055168 NA 0.53 6.11 0.32 2.81e-9 Developmental language disorder (linguistic errors); CRC trans rs853679 1.000 rs853679 chr6:28296863 C/A cg06606381 chr12:133084897 FBRSL1 -0.58 -6.11 -0.32 2.89e-9 Depression; CRC cis rs6860806 0.507 rs274572 chr5:131710917 T/G cg12564285 chr5:131593104 PDLIM4 -0.45 -7.55 -0.38 4.37e-13 Breast cancer; CRC cis rs597539 0.652 rs636049 chr11:68667198 A/C cg06112835 chr11:68658793 MRPL21 0.49 8.09 0.41 1.16e-14 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC trans rs11098499 0.644 rs10050092 chr4:120532085 T/C cg25214090 chr10:38739885 LOC399744 0.59 9.52 0.46 3.82e-19 Corneal astigmatism; CRC cis rs10504229 1.000 rs17805602 chr8:58179915 A/G cg05313129 chr8:58192883 C8orf71 -0.47 -6.99 -0.36 1.49e-11 Developmental language disorder (linguistic errors); CRC cis rs2952156 1.000 rs1565923 chr17:37858678 A/G cg00129232 chr17:37814104 STARD3 -0.7 -11.43 -0.53 1.09e-25 Asthma; CRC cis rs2228479 0.867 rs62052187 chr16:89973071 G/A cg06558623 chr16:89946397 TCF25 0.89 9.65 0.47 1.5e-19 Skin colour saturation; CRC cis rs6860806 0.507 rs2631369 chr5:131705266 G/C cg02033258 chr5:131593261 PDLIM4 -0.39 -6.76 -0.35 6.12e-11 Breast cancer; CRC cis rs9341808 0.718 rs9448886 chr6:80825901 C/T cg08355045 chr6:80787529 NA 0.43 6.9 0.36 2.64e-11 Sitting height ratio; CRC cis rs873946 0.504 rs3829132 chr10:134579044 A/C cg27286337 chr10:134555280 INPP5A 0.72 9.18 0.45 4.77e-18 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CRC cis rs12760731 0.720 rs12741848 chr1:178334941 A/G cg00404053 chr1:178313656 RASAL2 0.9 10.59 0.5 9.85e-23 Obesity-related traits; CRC cis rs6456156 0.586 rs10946209 chr6:167480991 G/A cg23791538 chr6:167370224 RNASET2 -0.4 -5.91 -0.31 8.73e-9 Primary biliary cholangitis; CRC cis rs3008870 0.755 rs2815368 chr1:67500778 C/T cg08660285 chr1:67390436 MIER1;WDR78 0.55 7.59 0.39 3.33e-13 Lymphocyte percentage of white cells; CRC cis rs853679 0.517 rs9348793 chr6:28084189 G/A cg03623178 chr6:28175578 NA 0.95 12.17 0.56 2.13e-28 Depression; CRC cis rs45509595 0.841 rs9368531 chr6:27781872 G/C cg26587870 chr6:27730563 NA -0.6 -5.98 -0.31 5.78e-9 Breast cancer; CRC cis rs13118159 0.714 rs6843025 chr4:1334418 C/G cg24560729 chr4:1342394 KIAA1530 0.43 7.84 0.4 6.44e-14 Longevity; CRC cis rs4713118 0.523 rs2179096 chr6:27665920 C/T cg20933634 chr6:27740509 NA 0.43 6.37 0.33 6.55e-10 Parkinson's disease; CRC trans rs6076960 0.629 rs6054024 chr20:6229282 A/C cg21095983 chr6:86352623 SYNCRIP 0.56 8.07 0.41 1.35e-14 Smooth-surface caries; CRC cis rs3733585 0.664 rs28602527 chr4:9958327 G/A cg11266682 chr4:10021025 SLC2A9 -0.47 -9.67 -0.47 1.2e-19 Cleft plate (environmental tobacco smoke interaction); CRC trans rs2727020 0.894 rs1880438 chr11:49370698 A/G cg15704280 chr7:45808275 SEPT13 -0.75 -9.98 -0.48 1.14e-20 Coronary artery disease; CRC cis rs731174 0.959 rs7546741 chr1:38191397 G/C cg06917450 chr1:38156652 C1orf109 -0.5 -7.07 -0.36 9.37e-12 Prostate cancer (SNP x SNP interaction); CRC cis rs951366 0.764 rs823141 chr1:205741426 T/C cg07157834 chr1:205819609 PM20D1 0.78 12.0 0.55 9.33e-28 Menarche (age at onset); CRC cis rs17152411 1.000 rs2241541 chr10:126671673 T/C cg07906193 chr10:126599966 NA 0.63 6.82 0.35 4.46e-11 Height; CRC cis rs1552244 0.935 rs35148833 chr3:10116937 C/A cg18598329 chr3:10140678 FANCD2;C3orf24 -0.87 -11.82 -0.55 4.24e-27 Alzheimer's disease; CRC cis rs7089973 0.872 rs34064819 chr10:116621154 C/A cg23260525 chr10:116636907 FAM160B1 0.31 6.82 0.35 4.38e-11 Bipolar disorder or attention deficit hyperactivity disorder; CRC cis rs7208859 0.623 rs9894709 chr17:29078454 G/A cg01831904 chr17:28903510 LRRC37B2 -0.62 -6.41 -0.33 5.05e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC trans rs7618501 0.521 rs11709573 chr3:49956628 C/T cg21659725 chr3:3221576 CRBN 0.46 6.63 0.34 1.34e-10 Intelligence (multi-trait analysis); CRC cis rs11098499 1.000 rs28374891 chr4:120183550 G/A cg09307838 chr4:120376055 NA 0.62 9.6 0.47 2.12e-19 Corneal astigmatism; CRC cis rs4253772 0.530 rs9627387 chr22:46684678 A/G cg24881330 chr22:46731750 TRMU 0.69 8.75 0.43 1.15e-16 LDL cholesterol;Cholesterol, total; CRC cis rs7605827 0.897 rs6745917 chr2:15537924 G/C cg19274914 chr2:15703543 NA 0.4 5.98 0.31 5.84e-9 Educational attainment (years of education); CRC trans rs2189609 0.521 rs2526066 chr16:74037837 A/C cg20115266 chr19:51416517 NA -0.4 -6.0 -0.31 5.18e-9 Energy expenditure (24h); CRC cis rs3733585 0.673 rs4455410 chr4:9953297 C/T cg11266682 chr4:10021025 SLC2A9 0.45 9.06 0.45 1.22e-17 Cleft plate (environmental tobacco smoke interaction); CRC cis rs514406 0.861 rs503015 chr1:53254456 T/C cg25767906 chr1:53392781 SCP2 0.47 7.48 0.38 6.61e-13 Monocyte count; CRC cis rs6598955 0.502 rs6683157 chr1:26545865 G/A cg04990556 chr1:26633338 UBXN11 0.84 9.9 0.48 2.17e-20 Obesity-related traits; CRC cis rs2204008 0.678 rs61929520 chr12:38446800 T/C cg26384229 chr12:38710491 ALG10B -0.52 -7.52 -0.38 5.23e-13 Bladder cancer; CRC cis rs12024301 0.557 rs114491252 chr1:183605243 C/G cg11505048 chr1:183622726 RGL1;APOBEC4 0.77 6.73 0.35 7.45e-11 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs7487075 0.780 rs12296120 chr12:46737591 G/A cg07601320 chr12:47219841 SLC38A4 0.28 5.78 0.3 1.77e-8 Itch intensity from mosquito bite; CRC cis rs2243480 1.000 rs67536397 chr7:65947917 G/A cg25985355 chr7:65971099 NA -0.53 -6.02 -0.32 4.64e-9 Diabetic kidney disease; CRC cis rs12681287 0.640 rs12678720 chr8:87457929 T/G cg27223183 chr8:87520930 FAM82B -0.52 -7.44 -0.38 8.7e-13 Caudate activity during reward; CRC cis rs7208859 0.623 rs76633166 chr17:29113365 C/T cg01831904 chr17:28903510 LRRC37B2 -0.62 -6.41 -0.33 5.13e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC trans rs7618501 1.000 rs1049256 chr3:49763338 T/C cg21582582 chr3:182698605 DCUN1D1 -0.56 -8.24 -0.41 4.05e-15 Intelligence (multi-trait analysis); CRC trans rs916888 0.821 rs415430 chr17:44859144 C/T cg10053473 chr17:62856997 LRRC37A3 0.71 8.39 0.42 1.42e-15 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs35000415 0.745 rs117473643 chr7:128698186 G/C cg19972273 chr7:128594194 NA 0.71 6.15 0.32 2.2e-9 Systemic lupus erythematosus; CRC cis rs7772486 0.603 rs2223411 chr6:146028767 T/C cg05347473 chr6:146136440 FBXO30 -0.48 -6.97 -0.36 1.7e-11 Lobe attachment (rater-scored or self-reported); CRC cis rs10504229 0.769 rs17804383 chr8:58151830 A/G cg11062466 chr8:58055876 NA 0.45 6.11 0.32 2.74e-9 Developmental language disorder (linguistic errors); CRC cis rs4713118 0.513 rs149972 chr6:27983227 C/T cg10876282 chr6:28092338 ZSCAN16 0.47 6.4 0.33 5.35e-10 Parkinson's disease; CRC cis rs10463316 0.894 rs7707964 chr5:150765475 C/T cg03212797 chr5:150827313 SLC36A1 -0.5 -7.78 -0.39 9.73e-14 Metabolite levels (Pyroglutamine); CRC cis rs67311347 1.000 rs1119179 chr3:40424929 A/C cg24209194 chr3:40518798 ZNF619 -0.4 -5.93 -0.31 7.86e-9 Renal cell carcinoma; CRC cis rs270601 0.739 rs1979981 chr5:131601720 G/A cg11843238 chr5:131593191 PDLIM4 0.49 9.31 0.46 1.86e-18 Acylcarnitine levels; CRC cis rs1862618 0.853 rs863840 chr5:56128999 C/G cg12311346 chr5:56204834 C5orf35 -0.75 -9.78 -0.47 5.18e-20 Initial pursuit acceleration; CRC cis rs6460942 0.915 rs62447641 chr7:12488764 G/A cg06484146 chr7:12443880 VWDE -0.77 -8.04 -0.41 1.69e-14 Coronary artery disease; CRC cis rs9322193 0.923 rs12205092 chr6:150082511 G/T cg00933542 chr6:150070202 PCMT1 0.32 6.34 0.33 7.63e-10 Lung cancer; CRC trans rs2228479 0.850 rs1800355 chr16:89813194 C/T cg21302420 chr1:112162376 RAP1A 0.72 6.01 0.31 5.05e-9 Skin colour saturation; CRC cis rs3087591 0.708 rs2189525 chr17:29668808 C/T cg24425628 chr17:29625626 OMG;NF1 -0.68 -12.3 -0.56 7.58e-29 Hip circumference; CRC cis rs1223397 0.651 rs202017 chr6:13301051 C/G cg07912922 chr6:13274314 PHACTR1 0.37 5.71 0.3 2.53e-8 Blood pressure; CRC cis rs780096 0.526 rs809058 chr2:27616790 T/C cg27432699 chr2:27873401 GPN1 -0.5 -7.56 -0.38 4.12e-13 Total body bone mineral density; CRC cis rs9914988 0.887 rs4795463 chr17:27146389 G/C cg20469991 chr17:27169893 C17orf63 -0.59 -7.19 -0.37 4.48e-12 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs736408 0.660 rs2019065 chr3:52809525 C/T cg11645453 chr3:52864694 ITIH4 -0.37 -6.72 -0.35 8.04e-11 Bipolar disorder; CRC cis rs1552244 1.000 rs17032414 chr3:10158302 C/G cg08888203 chr3:10149979 C3orf24 0.66 9.44 0.46 6.83e-19 Alzheimer's disease; CRC cis rs870825 1.000 rs72689245 chr4:185579788 G/A cg04058563 chr4:185651563 MLF1IP 0.72 7.35 0.38 1.54e-12 Blood protein levels; CRC cis rs6598955 0.670 rs6676619 chr1:26539035 T/G cg04990556 chr1:26633338 UBXN11 -0.8 -13.28 -0.59 1.68e-32 Obesity-related traits; CRC cis rs1451375 0.698 rs1839740 chr7:50646280 C/T cg14593290 chr7:50529359 DDC 0.51 7.11 0.37 7.09e-12 Malaria; CRC cis rs7208859 0.673 rs56846352 chr17:29119188 C/T cg13385521 chr17:29058706 SUZ12P 0.58 7.32 0.37 1.9e-12 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs4481887 0.962 rs10788769 chr1:248457426 C/T cg00666640 chr1:248458726 OR2T12 0.52 9.31 0.46 1.85e-18 Common traits (Other); CRC cis rs9916302 0.605 rs2879258 chr17:37399379 G/T cg00129232 chr17:37814104 STARD3 -0.6 -6.58 -0.34 1.9e-10 Glomerular filtration rate (creatinine); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg13490635 chr8:30242021 RBPMS 0.46 6.74 0.35 7.01e-11 Response to antipsychotic treatment; CRC cis rs4319547 0.737 rs7964138 chr12:122950375 A/G cg23029597 chr12:123009494 RSRC2 -0.56 -7.27 -0.37 2.6e-12 Body mass index; CRC cis rs910316 1.000 rs3742773 chr14:75579643 A/G cg11812906 chr14:75593930 NEK9 0.59 9.15 0.45 5.93e-18 Height; CRC cis rs9393692 0.645 rs11756673 chr6:26323505 A/G cg00631329 chr6:26305371 NA -0.72 -12.86 -0.58 6.04e-31 Educational attainment; CRC cis rs4474465 0.790 rs10793325 chr11:78252575 T/C cg27205649 chr11:78285834 NARS2 0.5 6.34 0.33 7.74e-10 Alzheimer's disease (survival time); CRC cis rs6582630 0.537 rs6582500 chr12:38534206 G/A cg26384229 chr12:38710491 ALG10B 0.71 9.58 0.47 2.43e-19 Drug-induced liver injury (flucloxacillin); CRC cis rs9649465 0.967 rs12538876 chr7:123296320 C/A cg03229431 chr7:123269106 ASB15 -0.37 -5.61 -0.3 4.36e-8 Migraine; CRC cis rs4665809 1.000 rs6729080 chr2:26301282 G/A cg04944784 chr2:26401820 FAM59B -0.6 -7.77 -0.39 1.01e-13 Gut microbiome composition (summer); CRC trans rs9914544 0.545 rs68046274 chr17:18785126 G/A cg21372672 chr17:16614065 CCDC144A -0.38 -5.98 -0.31 5.67e-9 Educational attainment (years of education); CRC cis rs896854 0.654 rs13274945 chr8:95986626 C/T cg09323728 chr8:95962352 TP53INP1 -0.44 -7.22 -0.37 3.69e-12 Type 2 diabetes; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg13580471 chr1:104068704 RNPC3 0.43 6.0 0.31 5.14e-9 Response to antipsychotic treatment; CRC cis rs9916302 0.851 rs7220650 chr17:37487168 A/G cg00129232 chr17:37814104 STARD3 0.5 7.39 0.38 1.24e-12 Glomerular filtration rate (creatinine); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg06382698 chr2:54015232 LOC100302652;ERLEC1;ASB3 0.45 6.6 0.34 1.64e-10 Intelligence (multi-trait analysis); CRC cis rs2239547 0.657 rs12496077 chr3:52886241 G/A cg11645453 chr3:52864694 ITIH4 0.59 10.51 0.5 1.79e-22 Schizophrenia; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg23137483 chr22:41682341 RANGAP1 0.46 6.01 0.31 5.03e-9 Anxiety disorder; CRC cis rs9372498 0.505 rs9481811 chr6:118801174 T/C cg07617317 chr6:118971624 C6orf204 0.51 6.26 0.33 1.21e-9 Diastolic blood pressure; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg04393905 chr3:53381207 DCP1A 0.46 6.4 0.33 5.28e-10 Response to antipsychotic treatment; CRC cis rs11212617 0.967 rs4987982 chr11:108151269 G/A cg14761454 chr11:108092087 ATM;NPAT 0.39 5.71 0.3 2.54e-8 Response to metformin in type 2 diabetes (glycemic); CRC cis rs9322193 0.923 rs10782310 chr6:149943594 A/G cg05861140 chr6:150128134 PCMT1 -0.36 -5.96 -0.31 6.46e-9 Lung cancer; CRC cis rs3793683 0.928 rs10781585 chr10:134553369 C/A cg06453172 chr10:134556979 INPP5A 0.49 7.63 0.39 2.51e-13 Migraine; CRC cis rs853679 0.517 rs2273564 chr6:28057594 A/T cg03623178 chr6:28175578 NA 0.96 12.48 0.57 1.62e-29 Depression; CRC cis rs10088262 0.629 rs7828192 chr8:124804669 C/T cg20713898 chr8:124780851 FAM91A1 -0.39 -5.73 -0.3 2.3e-8 Pancreatic cancer; CRC cis rs2836950 0.565 rs8134214 chr21:40542367 A/C cg11644478 chr21:40555479 PSMG1 -0.52 -7.93 -0.4 3.47e-14 Menarche (age at onset); CRC cis rs2836974 0.865 rs7282624 chr21:40667040 C/T cg06238570 chr21:40685208 BRWD1 0.79 10.97 0.52 4.45e-24 Cognitive function; CRC cis rs780096 0.526 rs2911713 chr2:27640980 G/A cg02592271 chr2:27665507 KRTCAP3 -0.26 -5.99 -0.31 5.49e-9 Total body bone mineral density; CRC cis rs172166 0.694 rs203884 chr6:28077374 G/T cg06470822 chr6:28175283 NA 0.8 11.86 0.55 3.05e-27 Cardiac Troponin-T levels; CRC cis rs939584 1.000 rs11127491 chr2:646145 T/C cg03610516 chr2:642275 NA 0.42 5.87 0.31 1.06e-8 Body mass index; CRC trans rs7618501 1.000 rs4855867 chr3:49745822 C/T cg21659725 chr3:3221576 CRBN -0.91 -17.91 -0.7 1.52e-50 Intelligence (multi-trait analysis); CRC cis rs2404602 0.716 rs12441550 chr15:76863682 A/T cg03037974 chr15:76606532 NA 0.66 11.44 0.53 9.38e-26 Blood metabolite levels; CRC trans rs7615952 0.932 rs13086087 chr3:125646281 A/C cg00769240 chr8:12517080 NA -0.56 -6.95 -0.36 1.92e-11 Blood pressure (smoking interaction); CRC cis rs10191773 0.589 rs72831636 chr2:112948248 G/A cg23609528 chr2:113191194 RGPD5;RGPD8 0.66 5.67 0.3 3.18e-8 Yeast infection; CRC cis rs2153535 0.601 rs9328487 chr6:8529378 G/C cg07606381 chr6:8435919 SLC35B3 0.68 11.04 0.52 2.48e-24 Motion sickness; CRC cis rs7264396 0.623 rs2590984 chr20:34597031 G/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.55 -8.96 -0.44 2.44e-17 Total cholesterol levels; CRC cis rs9902453 0.934 rs11080120 chr17:28507021 C/A cg26525008 chr17:28256777 EFCAB5;SSH2 0.59 9.25 0.45 3.01e-18 Coffee consumption (cups per day); CRC cis rs875971 0.756 rs4718328 chr7:65693337 A/G cg11764359 chr7:65958608 NA -0.61 -9.47 -0.46 5.59e-19 Aortic root size; CRC cis rs6951245 0.554 rs11761322 chr7:1151657 A/G cg20603222 chr7:1096387 C7orf50;GPR146 -0.44 -5.71 -0.3 2.54e-8 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs765787 0.530 rs55920042 chr15:45541577 G/A cg24006582 chr15:45444508 DUOX1 -0.57 -8.63 -0.43 2.62e-16 Uric acid levels; CRC cis rs3750082 0.748 rs10248427 chr7:32898969 C/G cg05721444 chr7:32995514 FKBP9 0.49 7.63 0.39 2.57e-13 Glomerular filtration rate (creatinine); CRC cis rs9291683 0.509 rs10939671 chr4:10050815 T/C cg11266682 chr4:10021025 SLC2A9 0.53 10.89 0.51 8.93e-24 Bone mineral density; CRC cis rs6496667 0.865 rs8043146 chr15:90850373 C/T cg04176472 chr15:90893244 GABARAPL3 0.56 7.23 0.37 3.37e-12 Rheumatoid arthritis; CRC cis rs4713118 0.715 rs200480 chr6:27773664 A/G cg02683197 chr6:28174875 NA 0.54 7.31 0.37 1.98e-12 Parkinson's disease; CRC cis rs1865760 0.516 rs9358903 chr6:26061949 A/C cg16482183 chr6:26056742 HIST1H1C 0.51 7.39 0.38 1.24e-12 Height; CRC cis rs9322193 0.847 rs56103941 chr6:150137231 A/G cg13206674 chr6:150067644 NUP43 0.67 9.22 0.45 3.63e-18 Lung cancer; CRC cis rs4969178 0.965 rs12450528 chr17:76395753 G/A cg20026190 chr17:76395443 PGS1 0.41 6.26 0.33 1.18e-9 HDL cholesterol levels; CRC cis rs72945132 0.882 rs67244582 chr11:70122009 G/A cg14191688 chr11:70257035 CTTN 0.42 5.85 0.31 1.18e-8 Coronary artery disease; CRC trans rs17742757 0.522 rs899364 chr8:11329544 G/T cg06636001 chr8:8085503 FLJ10661 -0.43 -5.98 -0.31 5.78e-9 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC cis rs1003719 0.788 rs59637309 chr21:38475398 G/A cg10648535 chr21:38446584 PIGP;TTC3 0.52 7.36 0.38 1.47e-12 Eye color traits; CRC cis rs17376456 0.877 rs13173952 chr5:93307557 A/T cg25358565 chr5:93447407 FAM172A 1.05 10.85 0.51 1.16e-23 Diabetic retinopathy; CRC cis rs9916302 0.706 rs590051 chr17:37446571 T/C cg07936489 chr17:37558343 FBXL20 0.83 10.29 0.49 1.02e-21 Glomerular filtration rate (creatinine); CRC cis rs12541635 0.966 rs55762012 chr8:107033218 T/C cg10147462 chr8:107024639 NA 0.44 7.27 0.37 2.6e-12 Age of smoking initiation; CRC cis rs6502050 0.835 rs4789668 chr17:80161990 C/T cg22110888 chr17:80059540 CCDC57 0.41 6.52 0.34 2.64e-10 Life satisfaction; CRC cis rs1008375 0.931 rs10008337 chr4:17593849 G/C cg16339924 chr4:17578868 LAP3 0.58 7.73 0.39 1.36e-13 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs9926296 0.605 rs12599180 chr16:89839306 C/T cg21285383 chr16:89894308 SPIRE2 -0.37 -6.21 -0.32 1.55e-9 Vitiligo; CRC cis rs7107174 1.000 rs10899451 chr11:77991222 A/C cg02023728 chr11:77925099 USP35 0.52 7.46 0.38 7.93e-13 Testicular germ cell tumor; CRC trans rs9329221 0.683 rs555200 chr8:9888729 A/G cg16141378 chr3:129829833 LOC729375 0.45 6.87 0.35 3.27e-11 Neuroticism; CRC cis rs6502050 0.842 rs9894129 chr17:80075700 A/G cg22110888 chr17:80059540 CCDC57 -0.42 -6.62 -0.34 1.48e-10 Life satisfaction; CRC cis rs1692580 0.846 rs377599 chr1:2164699 C/T cg24578937 chr1:2090814 PRKCZ 0.45 8.18 0.41 6.2e-15 Coronary artery disease; CRC cis rs11098499 0.863 rs12502389 chr4:120454191 A/G cg09307838 chr4:120376055 NA 0.69 10.34 0.5 6.68e-22 Corneal astigmatism; CRC cis rs2737618 0.674 rs2260033 chr1:200086074 G/A cg21825944 chr1:200113062 NR5A2 -0.52 -7.66 -0.39 2.11e-13 Uric acid levels; CRC cis rs4713118 0.786 rs200503 chr6:27785882 A/G cg12172441 chr6:28176163 NA 0.51 6.24 0.33 1.34e-9 Parkinson's disease; CRC cis rs394563 0.601 rs439495 chr6:149793224 A/G cg07828024 chr6:149772892 ZC3H12D 0.41 6.6 0.34 1.69e-10 Dupuytren's disease; CRC cis rs1448094 0.511 rs58742237 chr12:86166444 C/T cg19622623 chr12:86230825 RASSF9 -0.39 -5.98 -0.31 5.91e-9 Major depressive disorder; CRC cis rs72848980 0.512 rs61151381 chr10:105370496 C/G cg00126946 chr10:105363258 SH3PXD2A 0.51 6.38 0.33 5.93e-10 White matter hyperintensity burden; CRC trans rs7647973 0.593 rs55997059 chr3:49858661 A/T cg21659725 chr3:3221576 CRBN 0.68 7.91 0.4 3.82e-14 Menarche (age at onset); CRC cis rs13191362 0.935 rs35537826 chr6:163145867 G/A cg06582575 chr6:163149167 PACRG;PARK2 0.8 11.3 0.53 3.03e-25 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs4924935 1.000 rs9905565 chr17:18758641 C/T cg26378065 chr17:18585709 ZNF286B 0.42 5.78 0.3 1.76e-8 Pancreatic cancer; CRC cis rs13191362 0.507 rs2846535 chr6:163034019 T/C cg06582575 chr6:163149167 PACRG;PARK2 -0.55 -8.63 -0.43 2.69e-16 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs11227306 0.902 rs625652 chr11:65641931 T/A cg26695010 chr11:65641043 EFEMP2 0.43 6.17 0.32 1.97e-9 DNA methylation (variation); CRC cis rs9527 0.662 rs743575 chr10:104594906 T/G cg04362960 chr10:104952993 NT5C2 0.66 8.38 0.42 1.61e-15 Arsenic metabolism; CRC cis rs748404 0.560 rs689797 chr15:43826557 C/T cg02155558 chr15:43621948 ADAL;LCMT2 0.51 7.58 0.39 3.51e-13 Lung cancer; CRC cis rs6543140 0.964 rs13393175 chr2:103078849 T/G cg04239558 chr2:103089729 SLC9A4 0.37 6.59 0.34 1.72e-10 Blood protein levels; CRC cis rs3767633 0.800 rs2341479 chr1:161885352 C/A cg09175582 chr1:161736000 ATF6 0.61 5.9 0.31 9.26e-9 IgG glycosylation; CRC cis rs72772090 0.539 rs67140788 chr5:96116286 A/G cg17330273 chr5:96107758 CAST;ERAP1 -0.64 -5.9 -0.31 8.99e-9 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs7586879 0.789 rs36029941 chr2:25127801 C/T cg04586622 chr2:25135609 ADCY3 -0.57 -9.61 -0.47 1.91e-19 Body mass index; CRC cis rs9381040 0.655 rs2268193 chr6:41024625 A/G cg25110423 chr6:41068646 NFYA;LOC221442 -0.38 -5.77 -0.3 1.79e-8 Alzheimer's disease (late onset); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg13099106 chr12:120525172 CCDC64 0.45 6.47 0.34 3.49e-10 Response to antipsychotic treatment; CRC cis rs2839186 0.770 rs2280956 chr21:47642323 C/G cg08742575 chr21:47604166 C21orf56 -0.36 -5.6 -0.3 4.53e-8 Testicular germ cell tumor; CRC cis rs9894429 0.789 rs7213849 chr17:79567610 C/T cg18240062 chr17:79603768 NPLOC4 -0.66 -11.87 -0.55 2.74e-27 Eye color traits; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg02537909 chr2:165697595 COBLL1 0.44 6.36 0.33 6.77e-10 Response to antipsychotic treatment; CRC cis rs9649213 0.593 rs6465678 chr7:98004057 T/C cg24562669 chr7:97807699 LMTK2 0.42 6.95 0.36 2.01e-11 Prostate cancer (SNP x SNP interaction); CRC cis rs208520 0.526 rs6913344 chr6:66754285 A/C cg07460842 chr6:66804631 NA -1.09 -19.9 -0.74 2.19e-58 Exhaled nitric oxide output; CRC cis rs7666738 0.830 rs6853266 chr4:99047528 G/T cg05340658 chr4:99064831 C4orf37 0.6 9.11 0.45 8.26e-18 Colonoscopy-negative controls vs population controls; CRC cis rs1218582 0.745 rs1580943 chr1:154865125 G/A cg16680214 chr1:154839983 KCNN3 -0.48 -9.5 -0.46 4.65e-19 Prostate cancer; CRC cis rs2307022 0.586 rs1562479 chr16:68387373 C/T cg02226672 chr16:68398533 SMPD3 0.28 5.62 0.3 4.12e-8 Body mass index; CRC cis rs35306767 0.714 rs11250228 chr10:1074887 A/G cg26597838 chr10:835615 NA 0.66 8.6 0.43 3.26e-16 Eosinophil percentage of granulocytes; CRC cis rs7615952 0.688 rs7624806 chr3:125599074 G/A cg05084668 chr3:125655381 ALG1L -0.49 -6.67 -0.35 1.06e-10 Blood pressure (smoking interaction); CRC cis rs6547741 1.000 rs6547741 chr2:27855924 G/A cg27432699 chr2:27873401 GPN1 0.73 13.08 0.58 9.49e-32 Oral cavity cancer; CRC trans rs2727020 0.530 rs7113153 chr11:49457957 G/A cg11707556 chr5:10655725 ANKRD33B -0.47 -7.45 -0.38 8.08e-13 Coronary artery disease; CRC cis rs4234284 0.556 rs34147515 chr3:126965137 G/C cg27326032 chr3:127006922 NA -0.46 -6.95 -0.36 2.02e-11 Adverse response to chemotherapy in breast cancer (alopecia) (docetaxel); CRC cis rs11711311 1.000 rs11711311 chr3:113430599 T/G cg15478005 chr3:113465772 ATP6V1A;NAA50 0.45 6.13 0.32 2.49e-9 IgG glycosylation; CRC cis rs7726839 0.540 rs72703083 chr5:595365 C/T cg17948913 chr5:572064 NA 0.5 5.79 0.3 1.61e-8 Obesity-related traits; CRC cis rs763014 0.966 rs4984904 chr16:680809 C/G cg08989290 chr16:615782 NHLRC4 0.47 9.1 0.45 9.05e-18 Height; CRC cis rs9807989 0.708 rs6543124 chr2:102987459 T/A cg03938978 chr2:103052716 IL18RAP 0.37 6.07 0.32 3.6e-9 Asthma; CRC cis rs1552244 0.572 rs3843008 chr3:10173742 C/T cg10729496 chr3:10149963 C3orf24 0.58 6.07 0.32 3.62e-9 Alzheimer's disease; CRC cis rs7647973 0.626 rs9824435 chr3:49674343 A/G cg03060546 chr3:49711283 APEH -0.66 -7.34 -0.38 1.64e-12 Menarche (age at onset); CRC cis rs9311676 0.632 rs56288363 chr3:58374533 A/T cg06643156 chr3:58380774 PXK 0.41 6.33 0.33 7.82e-10 Systemic lupus erythematosus; CRC cis rs2274273 0.837 rs8011329 chr14:55677255 G/A cg23234261 chr14:55582407 NA -0.29 -5.66 -0.3 3.29e-8 Protein biomarker; CRC cis rs17270561 0.609 rs9393665 chr6:25744284 G/A cg17691542 chr6:26056736 HIST1H1C 0.72 9.24 0.45 3.07e-18 Iron status biomarkers; CRC cis rs478304 0.654 rs7947604 chr11:65442059 G/C cg27068330 chr11:65405492 SIPA1 -0.77 -11.69 -0.54 1.18e-26 Acne (severe); CRC cis rs611744 0.647 rs647907 chr8:109251374 T/C cg21045802 chr8:109455806 TTC35 0.42 6.65 0.34 1.19e-10 Dupuytren's disease; CRC cis rs9311676 0.656 rs12495490 chr3:58373251 A/G cg06643156 chr3:58380774 PXK 0.42 6.39 0.33 5.78e-10 Systemic lupus erythematosus; CRC cis rs703842 0.642 rs73123375 chr12:58063664 C/T cg00677455 chr12:58241039 CTDSP2 0.56 6.73 0.35 7.33e-11 Multiple sclerosis; CRC cis rs875971 0.895 rs1974769 chr7:65950614 G/A cg12463550 chr7:65579703 CRCP 0.47 6.71 0.35 8.61e-11 Aortic root size; CRC cis rs847577 0.609 rs6977321 chr7:97774859 A/G cg00277769 chr7:97922759 BAIAP2L1 -0.4 -6.81 -0.35 4.55e-11 Breast cancer; CRC cis rs9818758 0.607 rs55873331 chr3:49597055 C/T cg00383909 chr3:49044727 WDR6 1.37 12.07 0.55 5.27e-28 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; CRC cis rs17253792 0.555 rs17683626 chr14:56041112 G/T cg01858014 chr14:56050164 KTN1 -0.89 -6.88 -0.35 2.95e-11 Putamen volume; CRC cis rs9993810 1 rs9993810 chr4:77614640 G/A cg17476223 chr4:77663285 SHROOM3 0.43 5.77 0.3 1.88e-8 Magnesium levels; CRC cis rs7107174 1.000 rs11237462 chr11:78058812 C/A cg02023728 chr11:77925099 USP35 0.5 7.61 0.39 2.92e-13 Testicular germ cell tumor; CRC cis rs6502050 0.731 rs35156322 chr17:80096323 T/C cg19223190 chr17:80058835 NA 0.4 6.36 0.33 6.88e-10 Life satisfaction; CRC cis rs4665809 0.556 rs4665314 chr2:26415912 T/C cg22920501 chr2:26401640 FAM59B -0.83 -11.79 -0.55 5.27e-27 Gut microbiome composition (summer); CRC cis rs7647973 0.769 rs7434187 chr3:49032967 C/T cg07636037 chr3:49044803 WDR6 0.86 10.36 0.5 5.75e-22 Menarche (age at onset); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg10332367 chr16:2075476 SLC9A3R2 -0.4 -6.75 -0.35 6.56e-11 Liver disease severity in Alagille syndrome; CRC cis rs6496044 0.568 rs11636764 chr15:86079751 G/A cg17133734 chr15:86042851 AKAP13 0.42 6.78 0.35 5.63e-11 Interstitial lung disease; CRC cis rs7487075 0.820 rs12311507 chr12:46723190 T/A cg22049899 chr12:47219821 SLC38A4 0.34 6.65 0.34 1.21e-10 Itch intensity from mosquito bite; CRC cis rs7615952 0.576 rs66671308 chr3:125793526 T/G cg18479299 chr3:125709523 NA -0.55 -6.64 -0.34 1.27e-10 Blood pressure (smoking interaction); CRC cis rs853679 0.546 rs200981 chr6:27833174 A/G cg26587870 chr6:27730563 NA -0.65 -6.72 -0.35 7.9e-11 Depression; CRC cis rs2032447 0.517 rs7767546 chr6:25904067 T/C cg12310025 chr6:25882481 NA -0.76 -11.1 -0.52 1.61e-24 Intelligence (multi-trait analysis); CRC cis rs13108904 0.967 rs900027 chr4:1279360 G/A cg02018176 chr4:1364513 KIAA1530 0.49 7.96 0.4 2.77e-14 Obesity-related traits; CRC cis rs2243480 0.901 rs778687 chr7:65835819 G/A cg12463550 chr7:65579703 CRCP 0.7 6.26 0.33 1.22e-9 Diabetic kidney disease; CRC cis rs514406 0.861 rs503296 chr1:53283088 A/G cg27535305 chr1:53392650 SCP2 0.39 7.01 0.36 1.34e-11 Monocyte count; CRC trans rs7395662 0.570 rs11039737 chr11:48450200 G/A cg03929089 chr4:120376271 NA -0.46 -6.58 -0.34 1.88e-10 HDL cholesterol; CRC cis rs4713118 0.621 rs4713133 chr6:28034041 T/C cg15786705 chr6:28176104 NA 0.72 9.36 0.46 1.33e-18 Parkinson's disease; CRC cis rs7474896 0.537 rs1208587 chr10:38207759 A/G cg25427524 chr10:38739819 LOC399744 0.61 7.5 0.38 6.16e-13 Obesity (extreme); CRC cis rs72730918 0.590 rs6493514 chr15:51914778 T/G cg14296394 chr15:51910925 DMXL2 -0.47 -6.33 -0.33 8.14e-10 Intelligence (multi-trait analysis); CRC cis rs910316 1.000 rs10146482 chr14:75574087 C/T cg03030879 chr14:75389066 RPS6KL1 -0.45 -7.15 -0.37 5.79e-12 Height; CRC cis rs116095464 0.558 rs11959126 chr5:283880 T/G cg22496380 chr5:211416 CCDC127 -0.89 -10.1 -0.49 4.58e-21 Breast cancer; CRC cis rs4713118 0.621 rs10484403 chr6:28033523 A/G cg12963246 chr6:28129442 ZNF389 0.48 5.82 0.31 1.37e-8 Parkinson's disease; CRC cis rs12325245 0.536 rs34737210 chr16:58549262 T/C cg26666090 chr16:58549219 SETD6 1.01 6.67 0.35 1.06e-10 Schizophrenia; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg25798026 chr22:32149910 DEPDC5 0.44 7.57 0.39 3.68e-13 Liver disease severity in Alagille syndrome; CRC cis rs832540 0.629 rs10940512 chr5:56082094 G/C cg24531977 chr5:56204891 C5orf35 -0.53 -8.05 -0.41 1.5e-14 Coronary artery disease; CRC cis rs40363 0.645 rs4786421 chr16:3522303 A/G cg00484396 chr16:3507460 NAT15 -0.56 -8.76 -0.44 1.02e-16 Tuberculosis; CRC cis rs61008539 0.893 rs4719460 chr7:859610 C/T cg00475322 chr7:917719 C7orf20 -0.44 -7.79 -0.39 8.87e-14 Perceived unattractiveness to mosquitoes; CRC cis rs1800469 1.000 rs2241712 chr19:41869756 C/T cg08477640 chr19:41863820 B9D2 0.57 7.65 0.39 2.28e-13 Colorectal cancer; CRC cis rs743757 1.000 rs2236984 chr3:50495487 A/C cg08207895 chr3:50388901 TUSC4;CYB561D2 0.44 6.43 0.33 4.41e-10 Diastolic blood pressure; CRC cis rs9858542 0.953 rs12330269 chr3:49513910 G/A cg03060546 chr3:49711283 APEH -0.47 -6.56 -0.34 2.08e-10 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs6662572 0.737 rs10789477 chr1:46306583 A/G cg03123370 chr1:45965343 CCDC163P;MMACHC -0.48 -6.08 -0.32 3.31e-9 Blood protein levels; CRC cis rs863345 0.526 rs857676 chr1:158615702 G/A cg12129480 chr1:158549410 OR10X1 -0.31 -6.66 -0.34 1.17e-10 Pneumococcal bacteremia; CRC cis rs736408 0.546 rs3733046 chr3:52621627 C/T cg08222913 chr3:52553049 STAB1 -0.34 -6.35 -0.33 7.26e-10 Bipolar disorder; CRC cis rs6460942 0.915 rs7803002 chr7:12306738 C/T cg20607287 chr7:12443886 VWDE -0.46 -6.15 -0.32 2.27e-9 Coronary artery disease; CRC trans rs587242 1.000 rs663771 chr1:96891855 C/G cg10631902 chr5:14652156 NA 0.45 6.9 0.36 2.7e-11 Body mass index (joint analysis main effects and physical activity interaction);Body mass index in physically inactive individuals;Body mass index; CRC trans rs1005277 0.579 rs2749616 chr10:38510993 A/T cg17830980 chr10:43048298 ZNF37B -0.6 -9.99 -0.48 1.07e-20 Extrinsic epigenetic age acceleration; CRC cis rs9902453 0.730 rs2020939 chr17:28550732 A/G cg26525008 chr17:28256777 EFCAB5;SSH2 -0.47 -6.92 -0.36 2.38e-11 Coffee consumption (cups per day); CRC cis rs7412746 0.611 rs36008098 chr1:150856806 G/A cg15448220 chr1:150897856 SETDB1 0.46 6.53 0.34 2.52e-10 Melanoma; CRC cis rs7223966 1.000 rs112143304 chr17:61822401 T/A cg23090583 chr17:61904693 PSMC5;FTSJ3 0.57 6.58 0.34 1.89e-10 Hip circumference adjusted for BMI;Body mass index; CRC cis rs1580019 0.587 rs2392069 chr7:32547154 A/G cg07520158 chr7:32535189 LSM5;AVL9 0.55 8.08 0.41 1.25e-14 Cognitive ability; CRC cis rs11203032 0.634 rs3802658 chr10:90965691 C/T cg16672925 chr10:90967113 CH25H -0.45 -6.13 -0.32 2.47e-9 Heart failure; CRC cis rs12190007 0.514 rs2984462 chr6:169843903 A/T cg15038512 chr6:170123185 PHF10 -0.38 -5.9 -0.31 8.96e-9 Obesity-related traits; CRC cis rs10504229 1.000 rs73609760 chr8:58192170 A/G cg24829409 chr8:58192753 C8orf71 -0.69 -11.27 -0.53 3.85e-25 Developmental language disorder (linguistic errors); CRC trans rs11098499 0.866 rs12374244 chr4:120281972 A/T cg25214090 chr10:38739885 LOC399744 0.61 9.66 0.47 1.39e-19 Corneal astigmatism; CRC cis rs66887589 0.616 rs7659403 chr4:120207254 T/A cg09307838 chr4:120376055 NA 0.55 8.41 0.42 1.24e-15 Diastolic blood pressure; CRC cis rs8014671 0.597 rs8021180 chr14:70783943 A/G cg23702412 chr14:70655803 SLC8A3 -0.31 -5.96 -0.31 6.49e-9 Prostate cancer; CRC cis rs2386661 0.523 rs2386663 chr10:5652739 C/T cg26603656 chr10:5671107 NA 0.4 7.28 0.37 2.44e-12 Breast cancer; CRC cis rs796364 0.951 rs12996313 chr2:200997916 C/T cg25936922 chr2:200820526 C2orf60;C2orf47 -0.72 -7.76 -0.39 1.1e-13 Schizophrenia; CRC trans rs2303319 0.504 rs62189053 chr2:162624324 G/A cg04551154 chr10:95462393 C10orf4 -0.74 -6.34 -0.33 7.76e-10 Cognitive function; CRC cis rs2108225 0.900 rs2051956 chr7:107441358 G/C cg18560240 chr7:107437656 SLC26A3 -0.58 -9.03 -0.45 1.52e-17 Ulcerative colitis; CRC cis rs60871478 0.636 rs7792072 chr7:886239 C/T cg13844804 chr7:814759 HEATR2 -0.55 -5.81 -0.3 1.49e-8 Cerebrospinal P-tau181p levels; CRC cis rs6502050 0.835 rs8067138 chr17:80111026 T/C cg09264619 chr17:80180166 NA -0.34 -5.81 -0.3 1.5e-8 Life satisfaction; CRC cis rs2991971 0.810 rs2036021 chr1:45901370 G/A cg24296786 chr1:45957014 TESK2 0.47 6.86 0.35 3.36e-11 High light scatter reticulocyte count; CRC cis rs6815814 0.950 rs3924112 chr4:38795810 C/T cg06935464 chr4:38784597 TLR10 0.6 6.07 0.32 3.5e-9 Breast cancer; CRC cis rs1451375 1.000 rs1451375 chr7:50622712 A/C cg14593290 chr7:50529359 DDC -0.56 -7.81 -0.4 7.68e-14 Malaria; CRC cis rs28386778 0.897 rs2584615 chr17:61927774 T/C cg22520471 chr17:61851767 DDX42;CCDC47 0.73 11.34 0.53 2.15e-25 Prudent dietary pattern; CRC cis rs2153535 0.601 rs1737581 chr6:8539138 A/G cg07606381 chr6:8435919 SLC35B3 0.69 11.3 0.53 3.08e-25 Motion sickness; CRC cis rs7618915 0.547 rs12486847 chr3:52691112 T/C cg15147215 chr3:52552868 STAB1 -0.62 -10.31 -0.49 8.76e-22 Bipolar disorder; CRC cis rs7945705 0.747 rs11042150 chr11:9010819 T/C cg14711859 chr11:8959438 ASCL3 0.35 6.01 0.31 4.93e-9 Hemoglobin concentration; CRC trans rs7615952 0.546 rs2922197 chr3:125322032 G/A cg16558177 chr4:4109446 NA -0.56 -6.43 -0.33 4.42e-10 Blood pressure (smoking interaction); CRC cis rs9486719 1.000 rs13210597 chr6:96969694 C/A cg06623918 chr6:96969491 KIAA0776 -0.79 -9.31 -0.46 1.84e-18 Migraine;Coronary artery disease; CRC cis rs4665809 1.000 rs7599132 chr2:26279810 A/T cg27170947 chr2:26402098 FAM59B 0.46 6.16 0.32 2.13e-9 Gut microbiome composition (summer); CRC cis rs10927875 0.929 rs4661674 chr1:16296039 A/G cg21385522 chr1:16154831 NA -0.68 -9.11 -0.45 8.37e-18 Dilated cardiomyopathy; CRC cis rs6912958 0.712 rs6454640 chr6:88370352 G/T cg08069147 chr6:88032118 GJB7;C6orf162 0.54 7.99 0.4 2.23e-14 Monocyte percentage of white cells; CRC cis rs58688157 0.705 rs7928902 chr11:609068 G/A cg16486109 chr11:613632 IRF7 0.73 12.38 0.56 3.59e-29 Systemic lupus erythematosus; CRC cis rs1267303 0.675 rs1745370 chr1:46982863 C/G cg08533674 chr1:46993347 NA 0.72 9.17 0.45 5.32e-18 Monobrow; CRC cis rs4713118 0.586 rs6905522 chr6:28086479 A/C cg15845792 chr6:28175446 NA 1.0 13.1 0.59 7.81e-32 Parkinson's disease; CRC cis rs9309711 0.772 rs9752251 chr2:3489869 C/T cg10845886 chr2:3471009 TTC15 -0.7 -10.84 -0.51 1.26e-23 Neurofibrillary tangles; CRC cis rs8060686 0.920 rs73591961 chr16:67801309 G/A cg10544611 chr16:67998164 SLC12A4 -0.53 -5.64 -0.3 3.66e-8 HDL cholesterol;Metabolic syndrome; CRC cis rs4700695 0.764 rs251593 chr5:65313889 G/A cg21114390 chr5:65439923 SFRS12 0.57 6.99 0.36 1.58e-11 Facial morphology (factor 19); CRC cis rs8017423 0.608 rs12588149 chr14:90822676 G/A cg14092571 chr14:90743983 NA 0.38 5.85 0.31 1.17e-8 Mortality in heart failure; CRC cis rs7103648 0.669 rs12577383 chr11:47774238 C/T cg20307385 chr11:47447363 PSMC3 0.75 10.32 0.49 7.92e-22 Diastolic blood pressure;Systolic blood pressure; CRC cis rs1150668 0.796 rs1005125 chr6:28367355 G/A cg15845792 chr6:28175446 NA 0.58 8.54 0.43 5.14e-16 Pubertal anthropometrics; CRC cis rs4561483 0.545 rs9927446 chr16:11957164 A/T cg08843971 chr16:11963173 GSPT1 0.52 7.76 0.39 1.1e-13 Testicular germ cell tumor; CRC cis rs4803468 1.000 rs11883104 chr19:41923799 T/C cg09537434 chr19:41945824 ATP5SL -0.97 -18.77 -0.72 5.95e-54 Height; CRC cis rs7666738 0.715 rs116787789 chr4:98718720 G/A cg17366294 chr4:99064904 C4orf37 0.42 6.91 0.36 2.59e-11 Colonoscopy-negative controls vs population controls; CRC cis rs4243830 0.850 rs13513 chr1:6585804 C/T cg22792644 chr1:6614718 TAS1R1;NOL9 -0.71 -8.48 -0.42 7.97e-16 Body mass index; CRC trans rs11039798 0.920 rs12292685 chr11:48571032 G/T cg03929089 chr4:120376271 NA 0.62 6.09 0.32 3.17e-9 Axial length; CRC cis rs13256369 0.755 rs12550057 chr8:8562268 G/A cg06636001 chr8:8085503 FLJ10661 0.49 6.25 0.33 1.28e-9 Obesity-related traits; CRC cis rs10504229 0.683 rs55645894 chr8:58116145 A/G cg04204079 chr8:58130323 NA -0.45 -5.78 -0.3 1.71e-8 Developmental language disorder (linguistic errors); CRC cis rs875971 1.000 rs6460292 chr7:65810075 G/A cg11764359 chr7:65958608 NA -0.64 -10.41 -0.5 4.06e-22 Aortic root size; CRC cis rs7474896 0.559 rs1735629 chr10:38178309 C/T cg25427524 chr10:38739819 LOC399744 0.68 8.23 0.41 4.31e-15 Obesity (extreme); CRC cis rs8060686 0.641 rs1074143 chr16:68127278 A/G cg26727032 chr16:67993705 SLC12A4 -0.55 -6.31 -0.33 9.17e-10 HDL cholesterol;Metabolic syndrome; CRC cis rs9303280 0.806 rs4795395 chr17:37962987 T/A cg11212589 chr17:38028394 ZPBP2 0.36 6.71 0.35 8.34e-11 Self-reported allergy; CRC cis rs4076764 0.801 rs6698738 chr1:163359918 G/A cg24596788 chr1:163392923 NA -0.63 -10.14 -0.49 3.37e-21 Motion sickness; CRC cis rs7727544 0.735 rs2569266 chr5:131706791 T/C cg24060327 chr5:131705240 SLC22A5 0.39 6.34 0.33 7.36e-10 Blood metabolite levels; CRC cis rs9902453 0.765 rs34585141 chr17:28336432 G/T cg26525008 chr17:28256777 EFCAB5;SSH2 -0.69 -11.35 -0.53 2.01e-25 Coffee consumption (cups per day); CRC cis rs1799949 1.000 rs33918839 chr17:41329172 T/C cg23758822 chr17:41437982 NA 0.8 13.62 0.6 8.51e-34 Menopause (age at onset); CRC cis rs2153535 0.563 rs6942177 chr6:8534460 A/G cg21535247 chr6:8435926 SLC35B3 -0.47 -7.07 -0.36 9.32e-12 Motion sickness; CRC cis rs769267 0.930 rs10282 chr19:19619317 T/C cg01262667 chr19:19385393 TM6SF2 0.36 5.96 0.31 6.35e-9 Tonsillectomy; CRC cis rs6951245 1.000 rs80031817 chr7:1096793 T/C cg04025307 chr7:1156635 C7orf50 0.63 6.74 0.35 7.02e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs72717009 0.825 rs10494360 chr1:161475750 G/A cg23840854 chr1:161414152 NA -0.67 -7.98 -0.4 2.44e-14 Rheumatoid arthritis; CRC cis rs13108904 0.518 rs4974602 chr4:1342391 C/T cg02018176 chr4:1364513 KIAA1530 0.38 5.63 0.3 3.87e-8 Obesity-related traits; CRC cis rs736408 0.509 rs1108842 chr3:52720080 A/C cg10802521 chr3:52805072 NEK4 -0.49 -7.67 -0.39 1.96e-13 Bipolar disorder; CRC trans rs561341 1.000 rs693116 chr17:30246124 C/T cg20587970 chr11:113659929 NA -1.42 -20.11 -0.74 3.29e-59 Hip circumference adjusted for BMI; CRC cis rs12024301 0.557 rs12021522 chr1:183600257 C/T cg11505048 chr1:183622726 RGL1;APOBEC4 0.75 6.84 0.35 3.92e-11 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs1552244 0.572 rs113406084 chr3:10170190 T/C cg18598329 chr3:10140678 FANCD2;C3orf24 -0.9 -10.73 -0.51 3.19e-23 Alzheimer's disease; CRC cis rs1550532 0.632 rs1441093 chr2:234272484 A/G cg07618928 chr2:234183455 ATG16L1;SCARNA5 -0.53 -6.29 -0.33 1.03e-9 Calcium levels;Bilirubin levels; CRC cis rs6502050 0.626 rs11868521 chr17:80100195 T/G cg13939156 chr17:80058883 NA 0.39 5.99 0.31 5.37e-9 Life satisfaction; CRC cis rs9649213 0.614 rs3801258 chr7:97988428 G/A cg09267113 chr7:98030324 BAIAP2L1 -0.9 -11.81 -0.55 4.4e-27 Prostate cancer (SNP x SNP interaction); CRC cis rs2204008 0.605 rs4608149 chr12:38132057 G/C cg26384229 chr12:38710491 ALG10B 0.69 9.26 0.45 2.81e-18 Bladder cancer; CRC cis rs1707322 0.721 rs11211158 chr1:46132850 C/G cg03146154 chr1:46216737 IPP 0.67 9.75 0.47 6.98e-20 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs12701220 0.744 rs2030958 chr7:1076010 G/T cg26769984 chr7:1090371 C7orf50 0.75 9.94 0.48 1.54e-20 Bronchopulmonary dysplasia; CRC cis rs1153858 0.943 rs28605551 chr15:45641720 C/T cg14582100 chr15:45693742 SPATA5L1 0.28 5.85 0.31 1.16e-8 Homoarginine levels; CRC cis rs7618501 0.540 rs11130241 chr3:50131459 A/T cg24110177 chr3:50126178 RBM5 0.48 7.17 0.37 4.97e-12 Intelligence (multi-trait analysis); CRC cis rs10751667 0.643 rs10902238 chr11:944810 G/A cg06064525 chr11:970664 AP2A2 -0.33 -6.71 -0.35 8.44e-11 Alzheimer's disease (late onset); CRC cis rs1451375 0.617 rs745043 chr7:50543955 T/G cg18232548 chr7:50535776 DDC -0.44 -5.8 -0.3 1.57e-8 Malaria; CRC cis rs7804356 0.954 rs3801809 chr7:26895456 G/A cg03456212 chr7:26904342 SKAP2 -0.49 -5.61 -0.3 4.33e-8 Type 1 diabetes; CRC cis rs28493229 0.500 rs45545932 chr19:41190875 G/A cg21869046 chr19:41225005 ITPKC 0.38 5.94 0.31 7.17e-9 Kawasaki disease; CRC cis rs11758351 1.000 rs79264785 chr6:26194121 C/T cg01420254 chr6:26195488 NA 0.83 8.68 0.43 1.82e-16 Gout;Renal underexcretion gout; CRC cis rs9359856 0.957 rs9342201 chr6:90310356 G/T cg13799429 chr6:90582589 CASP8AP2 0.44 6.33 0.33 7.84e-10 Bipolar disorder; CRC cis rs9916302 0.904 rs9898170 chr17:37510092 T/C cg07936489 chr17:37558343 FBXL20 0.82 12.31 0.56 6.59e-29 Glomerular filtration rate (creatinine); CRC cis rs2836974 0.644 rs1882779 chr21:40690938 T/C cg17971929 chr21:40555470 PSMG1 -0.62 -8.86 -0.44 5.12e-17 Cognitive function; CRC cis rs1784581 0.894 rs1626020 chr6:162383379 G/A cg17173639 chr6:162384350 PARK2 -0.83 -14.8 -0.63 2.33e-38 Itch intensity from mosquito bite; CRC cis rs2836974 0.568 rs2183573 chr21:40574305 A/G cg22974920 chr21:40686053 BRWD1 -0.44 -6.17 -0.32 2.02e-9 Cognitive function; CRC cis rs6089584 0.927 rs2281734 chr20:60582401 C/A cg06108461 chr20:60628389 TAF4 -0.73 -12.4 -0.56 3.05e-29 Body mass index; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg02830023 chr6:15575773 DTNBP1 0.35 6.38 0.33 6.14e-10 Liver disease severity in Alagille syndrome; CRC cis rs9443645 0.869 rs10943609 chr6:79676328 A/T cg09184832 chr6:79620586 NA -0.51 -9.4 -0.46 9.26e-19 Intelligence (multi-trait analysis); CRC trans rs7395662 1.000 rs10838943 chr11:48557442 T/G cg21153622 chr11:89784906 NA -0.45 -7.24 -0.37 3.25e-12 HDL cholesterol; CRC cis rs10503871 0.967 rs4403367 chr8:30439724 A/G cg26383811 chr8:30366931 RBPMS 0.46 7.41 0.38 1.09e-12 Metabolite levels (X-11787); CRC cis rs1552244 1.000 rs6442148 chr3:10078289 G/C cg02579736 chr3:10068473 FANCD2;CIDECP 0.96 13.19 0.59 3.5e-32 Alzheimer's disease; CRC cis rs709400 0.520 rs28583452 chr14:103938664 C/A cg12935359 chr14:103987150 CKB -0.5 -8.01 -0.4 2.02e-14 Body mass index; CRC cis rs611744 0.647 rs11785776 chr8:109264933 C/T cg18478394 chr8:109455254 TTC35 0.39 6.05 0.32 4e-9 Dupuytren's disease; CRC cis rs4665809 0.549 rs17527979 chr2:26428132 A/G cg26119090 chr2:26468346 HADHA;HADHB -1.0 -12.66 -0.57 3.31e-30 Gut microbiome composition (summer); CRC cis rs2014572 0.875 rs10405008 chr19:57753643 C/G cg24459738 chr19:57751996 ZNF805 0.55 8.76 0.43 1.03e-16 Hyperactive-impulsive symptoms; CRC cis rs3740540 0.530 rs2362505 chr10:126290739 T/G cg04949429 chr10:126290192 LHPP 0.43 6.35 0.33 7.13e-10 Obesity-related traits;Acute lymphoblastic leukemia (childhood); CRC cis rs6546550 0.933 rs57278310 chr2:70093647 T/C cg02498382 chr2:70120550 SNRNP27 -0.42 -6.73 -0.35 7.51e-11 Prevalent atrial fibrillation; CRC cis rs3749237 0.537 rs4459909 chr3:49469217 T/C cg07636037 chr3:49044803 WDR6 0.55 8.1 0.41 1.05e-14 Resting heart rate; CRC cis rs4319547 0.626 rs11057882 chr12:122875046 A/G cg05707623 chr12:122985044 ZCCHC8 -0.73 -8.76 -0.44 1.02e-16 Body mass index; CRC cis rs7586879 0.796 rs11684619 chr2:25078859 G/A cg04586622 chr2:25135609 ADCY3 -0.55 -9.37 -0.46 1.22e-18 Body mass index; CRC cis rs372883 0.509 rs28462110 chr21:30544318 C/T cg24692254 chr21:30365293 RNF160 -0.38 -5.61 -0.3 4.3e-8 Pancreatic cancer; CRC cis rs1799949 1.000 rs16941 chr17:41244435 T/C cg25072359 chr17:41440525 NA 0.45 6.64 0.34 1.29e-10 Menopause (age at onset); CRC cis rs7809950 0.678 rs2237659 chr7:106847492 G/T cg23024343 chr7:107201750 COG5 0.69 8.92 0.44 3.19e-17 Coronary artery disease; CRC cis rs6570726 0.791 rs9390336 chr6:145896823 A/T cg23711669 chr6:146136114 FBXO30 0.69 11.52 0.54 4.94e-26 Lobe attachment (rater-scored or self-reported); CRC cis rs7666738 0.606 rs7663216 chr4:99088385 A/C cg05340658 chr4:99064831 C4orf37 0.49 7.19 0.37 4.52e-12 Colonoscopy-negative controls vs population controls; CRC cis rs7647973 1.000 rs974495 chr3:49400482 T/C cg20833759 chr3:49053208 WDR6;DALRD3 0.57 8.85 0.44 5.5e-17 Menarche (age at onset); CRC cis rs11212617 0.967 rs3781869 chr11:108059000 T/C cg01991180 chr11:108092276 ATM;NPAT 0.41 5.87 0.31 1.07e-8 Response to metformin in type 2 diabetes (glycemic); CRC cis rs12701220 0.655 rs9638973 chr7:1133678 A/G cg04498913 chr7:1135747 C7orf50 -0.49 -5.92 -0.31 8.04e-9 Bronchopulmonary dysplasia; CRC cis rs11098499 0.954 rs12506546 chr4:120301618 T/C cg09307838 chr4:120376055 NA 0.7 10.79 0.51 1.87e-23 Corneal astigmatism; CRC cis rs597539 0.518 rs35093305 chr11:68730729 A/G cg21963583 chr11:68658836 MRPL21 0.55 9.67 0.47 1.27e-19 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs62408225 1.000 rs72925996 chr6:90930513 T/C cg06866423 chr6:90926672 BACH2 0.48 7.55 0.38 4.29e-13 Eosinophil counts;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC cis rs17713451 0.593 rs17642575 chr7:151261450 T/C cg18404559 chr7:151322523 PRKAG2 -0.56 -6.28 -0.33 1.04e-9 Interleukin-4 levels; CRC cis rs3820928 0.934 rs60141402 chr2:227761445 A/C cg11843606 chr2:227700838 RHBDD1 -0.4 -5.7 -0.3 2.67e-8 Pulmonary function; CRC cis rs9287719 1.000 rs9679122 chr2:10751710 T/C cg00105475 chr2:10696890 NA 0.45 7.17 0.37 4.86e-12 Prostate cancer; CRC cis rs7809950 0.862 rs2299421 chr7:106946195 C/G cg23024343 chr7:107201750 COG5 -0.48 -6.98 -0.36 1.59e-11 Coronary artery disease; CRC cis rs28386778 0.863 rs3760252 chr17:61852186 G/C cg22520471 chr17:61851767 DDX42;CCDC47 0.76 11.8 0.55 5e-27 Prudent dietary pattern; CRC cis rs79387448 0.745 rs1159509 chr2:103169073 T/A cg09003973 chr2:102972529 NA 0.74 8.07 0.41 1.3e-14 Gut microbiota (bacterial taxa); CRC cis rs9547692 1.000 rs61950374 chr13:37475485 C/T cg01493522 chr13:37497338 NA -0.53 -7.33 -0.37 1.83e-12 Coronary artery disease; CRC trans rs1814175 0.616 rs4881723 chr11:49788566 G/T cg11707556 chr5:10655725 ANKRD33B -0.52 -9.85 -0.48 3.12e-20 Height; CRC cis rs9326248 1.000 rs664082 chr11:117071070 C/G cg10130564 chr11:117069849 TAGLN 0.38 7.08 0.36 8.52e-12 Blood protein levels; CRC cis rs4969178 0.931 rs3826323 chr17:76400268 C/G cg20026190 chr17:76395443 PGS1 0.38 5.68 0.3 2.95e-8 HDL cholesterol levels; CRC cis rs9393692 1.000 rs2393593 chr6:26285683 T/C cg13736514 chr6:26305472 NA -0.66 -12.02 -0.55 8.04e-28 Educational attainment; CRC cis rs853679 0.542 rs9380063 chr6:28137853 A/G cg12963246 chr6:28129442 ZNF389 0.49 5.7 0.3 2.71e-8 Depression; CRC trans rs11098499 0.644 rs28787668 chr4:120554687 G/A cg25214090 chr10:38739885 LOC399744 0.58 9.18 0.45 4.73e-18 Corneal astigmatism; CRC cis rs1997103 1.000 rs4947501 chr7:55407342 C/T cg17469321 chr7:55412551 NA 0.72 11.28 0.53 3.48e-25 QRS interval (sulfonylurea treatment interaction); CRC cis rs3741404 0.560 rs17699798 chr11:63898806 C/G cg18225595 chr11:63971243 STIP1 -0.47 -7.61 -0.39 2.91e-13 Platelet count; CRC cis rs9527 0.590 rs7067663 chr10:104883650 A/G cg15744005 chr10:104629667 AS3MT -0.31 -6.02 -0.32 4.54e-9 Arsenic metabolism; CRC cis rs10779751 0.960 rs1883964 chr1:11294942 T/A cg08854313 chr1:11322531 MTOR 0.66 9.35 0.46 1.38e-18 Body mass index; CRC trans rs2243480 1.000 rs13237037 chr7:65997882 T/C cg10756647 chr7:56101905 PSPH 0.76 7.92 0.4 3.72e-14 Diabetic kidney disease; CRC cis rs950776 0.518 rs2292117 chr15:78834689 C/T cg06917634 chr15:78832804 PSMA4 0.66 10.69 0.51 4.25e-23 Sudden cardiac arrest; CRC cis rs651907 0.557 rs7651721 chr3:101393583 C/A cg11279151 chr3:101281821 RG9MTD1 -0.57 -7.73 -0.39 1.33e-13 Colorectal cancer; CRC cis rs7147624 0.882 rs1956008 chr14:66085429 G/T cg03016385 chr14:66212404 NA -1.04 -10.76 -0.51 2.48e-23 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs11971779 0.618 rs10085814 chr7:139064089 A/G cg07862535 chr7:139043722 LUC7L2 0.57 7.35 0.38 1.61e-12 Diisocyanate-induced asthma; CRC cis rs62064224 0.553 rs9896320 chr17:30689814 G/A cg25809561 chr17:30822961 MYO1D 0.51 9.19 0.45 4.68e-18 Schizophrenia; CRC cis rs13082711 0.554 rs1494422 chr3:27375190 T/C cg02860705 chr3:27208620 NA -0.69 -9.11 -0.45 8.3e-18 Systolic blood pressure;Diastolic blood pressure;Blood pressure; CRC cis rs2549003 0.966 rs10065633 chr5:131816716 T/C cg00255919 chr5:131827918 IRF1 0.59 11.88 0.55 2.57e-27 Asthma (sex interaction); CRC cis rs9992667 0.826 rs7656708 chr4:38641662 G/A cg19726192 chr4:38663646 FLJ13197 -0.67 -8.73 -0.43 1.31e-16 Eosinophil percentage of granulocytes; CRC cis rs2243480 1.000 rs778679 chr7:65840911 A/G cg18252515 chr7:66147081 NA -1.3 -15.32 -0.65 2.37e-40 Diabetic kidney disease; CRC cis rs832540 0.512 rs33320 chr5:56206529 C/T cg20203395 chr5:56204925 C5orf35 -0.43 -5.87 -0.31 1.06e-8 Coronary artery disease; CRC cis rs7737355 0.898 rs1016068 chr5:131100246 T/C cg06307176 chr5:131281290 NA 0.43 6.36 0.33 6.62e-10 Life satisfaction; CRC trans rs61931739 0.500 rs34703942 chr12:34583776 T/C cg13010199 chr12:38710504 ALG10B -0.47 -6.66 -0.34 1.15e-10 Morning vs. evening chronotype; CRC cis rs17065868 1.000 rs9533938 chr13:45222796 T/A cg10246903 chr13:45222710 NA 0.53 6.39 0.33 5.55e-10 Antineutrophil cytoplasmic antibody-associated vasculitis; CRC cis rs7605827 0.897 rs6431713 chr2:15691382 C/T cg19274914 chr2:15703543 NA 0.38 5.8 0.3 1.59e-8 Educational attainment (years of education); CRC cis rs17376456 0.569 rs6895356 chr5:93060781 A/G cg25358565 chr5:93447407 FAM172A 0.65 7.93 0.4 3.4e-14 Diabetic retinopathy; CRC cis rs11622475 1.000 rs56060232 chr14:104386165 G/C cg12183467 chr14:104352244 NA -0.52 -7.12 -0.37 6.8e-12 Bipolar disorder; CRC cis rs798554 0.679 rs1636254 chr7:2885724 T/C cg19346786 chr7:2764209 NA -0.39 -6.82 -0.35 4.51e-11 Height; CRC cis rs28386778 0.897 rs8079818 chr17:61824667 C/G cg06873352 chr17:61820015 STRADA 0.79 14.96 0.64 5.94e-39 Prudent dietary pattern; CRC cis rs1784581 0.546 rs1954917 chr6:162447490 C/T cg17173639 chr6:162384350 PARK2 0.55 8.45 0.42 9.32e-16 Itch intensity from mosquito bite; CRC cis rs2717559 0.542 rs2717586 chr8:143897882 C/T cg20541178 chr8:143858627 LYNX1 0.34 6.13 0.32 2.5e-9 Urinary tract infection frequency; CRC cis rs995000 0.899 rs1184865 chr1:62973795 A/G cg19896129 chr1:63156450 NA -0.38 -5.9 -0.31 9.28e-9 Triglyceride levels; CRC cis rs2425143 0.730 rs6579259 chr20:34462550 C/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.5 -5.66 -0.3 3.28e-8 Blood protein levels; CRC trans rs11098499 0.754 rs9991959 chr4:120253773 C/T cg25214090 chr10:38739885 LOC399744 -0.5 -7.84 -0.4 6.13e-14 Corneal astigmatism; CRC cis rs9611565 0.765 rs28604950 chr22:41785812 A/G cg06634786 chr22:41940651 POLR3H -0.66 -7.69 -0.39 1.7e-13 Vitiligo; CRC trans rs9929218 1.000 rs13330350 chr16:68800849 C/T cg04657470 chr2:198365150 HSPE1;HSPD1 -0.83 -11.86 -0.55 2.96e-27 Colorectal cancer; CRC cis rs2839186 0.732 rs55904887 chr21:47707811 A/G cg09417038 chr21:47716443 C21orf57 -0.42 -6.93 -0.36 2.21e-11 Testicular germ cell tumor; CRC cis rs995000 0.931 rs659656 chr1:62912120 C/G cg19896129 chr1:63156450 NA 0.44 6.8 0.35 4.87e-11 Triglyceride levels; CRC cis rs11122272 0.735 rs2246645 chr1:231497393 T/G cg06096015 chr1:231504339 EGLN1 0.39 6.0 0.31 5.11e-9 Hemoglobin concentration; CRC cis rs72634258 0.554 rs17374781 chr1:7919363 A/G cg26816564 chr1:7831052 VAMP3 -0.72 -8.82 -0.44 6.75e-17 Inflammatory bowel disease; CRC cis rs7216064 1.000 rs73352808 chr17:65875157 G/A cg12091567 chr17:66097778 LOC651250 -0.61 -7.61 -0.39 2.86e-13 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CRC cis rs853679 0.517 rs35512245 chr6:28079953 T/C cg06470822 chr6:28175283 NA 1.0 13.03 0.58 1.36e-31 Depression; CRC cis rs11227306 0.934 rs10896056 chr11:65587905 A/G cg26695010 chr11:65641043 EFEMP2 -0.48 -6.46 -0.34 3.86e-10 DNA methylation (variation); CRC cis rs4700695 0.641 rs386949 chr5:65231061 G/A cg21114390 chr5:65439923 SFRS12 0.61 6.3 0.33 9.74e-10 Facial morphology (factor 19); CRC cis rs12464483 0.591 rs72800120 chr2:30897122 G/A cg17749961 chr2:30669863 LCLAT1 0.53 5.7 0.3 2.65e-8 Pre-treatment pain in head and neck squamous cell carcinoma; CRC cis rs2806561 0.765 rs9426692 chr1:23508426 C/T cg12483005 chr1:23474871 LUZP1 0.5 7.27 0.37 2.58e-12 Height; CRC cis rs9814567 0.964 rs9833753 chr3:134213665 A/G cg06109529 chr3:134205091 CEP63;ANAPC13 -0.81 -12.26 -0.56 1e-28 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs7927592 0.513 rs653056 chr11:68203625 T/C cg01657329 chr11:68192670 LRP5 -0.6 -9.77 -0.47 5.99e-20 Total body bone mineral density; CRC cis rs2286885 1.000 rs2277159 chr9:129243383 C/T cg15282417 chr9:129245246 FAM125B 0.44 8.03 0.4 1.73e-14 Intraocular pressure; CRC cis rs4722166 0.508 rs1474348 chr7:22767908 C/G cg05472934 chr7:22766657 IL6 0.78 12.92 0.58 3.75e-31 Lung cancer; CRC cis rs6479527 0.840 rs4282631 chr9:96764410 T/C cg14459158 chr9:96720562 NA 0.41 7.49 0.38 6.39e-13 Esophageal adenocarcinoma; CRC cis rs11628318 0.853 rs4906226 chr14:103027359 C/T cg23461800 chr14:103021989 NA -0.76 -10.02 -0.48 8.31e-21 Platelet count; CRC cis rs727563 0.648 rs6002406 chr22:41965237 A/T cg03806693 chr22:41940476 POLR3H -1.08 -12.62 -0.57 4.86e-30 Crohn's disease;Inflammatory bowel disease; CRC cis rs72945132 0.882 rs6592537 chr11:70172975 C/T cg00319359 chr11:70116639 PPFIA1 0.66 7.32 0.37 1.94e-12 Coronary artery disease; CRC cis rs780094 0.544 rs780110 chr2:27685388 G/A cg02592271 chr2:27665507 KRTCAP3 -0.25 -5.82 -0.31 1.42e-8 Calcium levels;Fasting blood insulin;Metabolic traits;Triglyceride levels;Fasting plasma glucose;Urate levels in overweight individuals;Urate levels in obese individuals;Uric acid levels;Height;Age-related diseases, mortality and associated endophenotypes;Renal underexcretion gout;Fasting blood glucose (BMI interaction);Urate levels;Gondoic acid (20:1n-9) levels;Fasting blood insulin (BMI interaction);Triglycerides;Plasma omega-3 polyunsaturated fatty acid levels (docosapentaenoic acid);Type 2 diabetes;Nonalcoholic fatty liver disease;Hypertriglyceridemia;C-reactive protein;Age-related disease endophenotypes;LDL cholesterol;Metabolic syndrome;Crohn's disease;Alcohol consumption (drinks per week);Homeostasis model assessment of insulin resistance;Alcohol consumption;Red blood cell count;Fasting blood glucose; CRC cis rs889312 0.500 rs252906 chr5:56119190 G/T cg24531977 chr5:56204891 C5orf35 -0.42 -6.34 -0.33 7.79e-10 Breast cancer;Breast cancer (early onset); CRC cis rs1799949 0.501 rs35399157 chr17:41411602 G/C cg25072359 chr17:41440525 NA 0.45 6.86 0.35 3.32e-11 Menopause (age at onset); CRC cis rs6502050 0.765 rs6502074 chr17:80121776 T/C cg25804541 chr17:80189381 SLC16A3 -0.32 -6.15 -0.32 2.28e-9 Life satisfaction; CRC cis rs13256369 0.802 rs1060106 chr8:8561452 A/G cg00074818 chr8:8560427 CLDN23 0.41 7.36 0.38 1.45e-12 Obesity-related traits; CRC cis rs9372498 0.536 rs17424234 chr6:118808521 A/G cg22561889 chr6:118971681 C6orf204 0.48 5.95 0.31 7.02e-9 Diastolic blood pressure; CRC cis rs1005277 0.522 rs7090858 chr10:38003670 A/C cg25517755 chr10:38738941 LOC399744 0.43 6.29 0.33 1e-9 Extrinsic epigenetic age acceleration; CRC cis rs7312933 0.898 rs10880221 chr12:42384589 C/A cg01256987 chr12:42539512 GXYLT1 -0.4 -6.16 -0.32 2.11e-9 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CRC cis rs2204008 0.744 rs11514358 chr12:38255526 G/A cg26384229 chr12:38710491 ALG10B 0.69 9.22 0.45 3.69e-18 Bladder cancer; CRC cis rs875971 0.522 rs4502988 chr7:65297746 A/G cg00343986 chr7:65444356 GUSB 0.56 8.52 0.43 5.66e-16 Aortic root size; CRC cis rs4862750 0.914 rs9995391 chr4:187873749 A/T cg03647317 chr4:187891568 NA 0.54 10.03 0.48 7.63e-21 Lobe attachment (rater-scored or self-reported); CRC cis rs514406 0.929 rs12410420 chr1:53323754 T/C cg25767906 chr1:53392781 SCP2 -0.46 -7.39 -0.38 1.25e-12 Monocyte count; CRC cis rs4728302 0.934 rs4129572 chr7:133636888 T/C cg10665199 chr7:133106180 EXOC4 -0.39 -6.14 -0.32 2.34e-9 Intelligence;Intelligence (multi-trait analysis); CRC cis rs4594175 0.926 rs60234748 chr14:51630102 T/C cg23942311 chr14:51606299 NA 0.63 10.38 0.5 5.13e-22 Cancer; CRC trans rs12639288 0.962 rs12638639 chr3:167660757 C/T cg21357108 chr17:15164082 PMP22 -0.49 -6.01 -0.31 4.79e-9 Hirschsprung disease; CRC cis rs10504229 0.906 rs59336968 chr8:58176857 T/C cg05313129 chr8:58192883 C8orf71 -0.47 -6.99 -0.36 1.49e-11 Developmental language disorder (linguistic errors); CRC cis rs863345 0.604 rs7544134 chr1:158475421 G/T cg12129480 chr1:158549410 OR10X1 -0.3 -6.33 -0.33 7.99e-10 Pneumococcal bacteremia; CRC cis rs11599315 0.507 rs12217329 chr10:1341897 A/G cg09624528 chr10:1369823 ADARB2 0.39 5.87 0.31 1.04e-8 Thiazide-induced adverse metabolic effects in hypertensive patients; CRC cis rs473651 0.935 rs35080527 chr2:239351387 T/C cg18131467 chr2:239335373 ASB1 1.03 23.34 0.79 9.54e-72 Multiple system atrophy; CRC trans rs7618501 1.000 rs7618501 chr3:49772647 A/G cg21582582 chr3:182698605 DCUN1D1 -0.56 -8.34 -0.42 2.09e-15 Intelligence (multi-trait analysis); CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg26143326 chr5:218493 SDHA;CCDC127 0.49 6.92 0.36 2.4e-11 Anxiety disorder; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg16699849 chr7:98923489 ARPC1A 0.37 6.31 0.33 9.14e-10 Liver disease severity in Alagille syndrome; CRC cis rs1008375 1.000 rs10027755 chr4:17615954 G/C cg16339924 chr4:17578868 LAP3 0.54 7.38 0.38 1.28e-12 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs2421770 0.530 rs3847622 chr11:35368700 A/G cg13971030 chr11:35366721 SLC1A2 0.37 6.49 0.34 3.08e-10 Staphylococcus aureus nasal carriage (persistent); CRC cis rs898097 0.625 rs7406464 chr17:80891460 A/G cg10494973 chr17:80897199 TBCD 0.36 5.77 0.3 1.83e-8 Breast cancer; CRC cis rs2996428 0.667 rs113120570 chr1:3770450 G/C cg13057898 chr1:3703894 LRRC47 0.52 6.91 0.36 2.46e-11 Red cell distribution width; CRC cis rs4474465 1.000 rs10899534 chr11:78210502 G/C cg27205649 chr11:78285834 NARS2 0.47 5.68 0.3 3e-8 Alzheimer's disease (survival time); CRC cis rs7731657 0.537 rs4637539 chr5:130311944 T/C cg08523029 chr5:130500466 HINT1 -0.49 -6.16 -0.32 2.1e-9 Fasting plasma glucose; CRC cis rs3096299 0.967 rs28689480 chr16:89460093 T/C cg01788221 chr16:89496183 ANKRD11 -0.44 -6.52 -0.34 2.59e-10 Multiple myeloma (IgH translocation); CRC cis rs6570726 0.935 rs451349 chr6:145820894 A/G cg23711669 chr6:146136114 FBXO30 0.68 12.16 0.56 2.33e-28 Lobe attachment (rater-scored or self-reported); CRC cis rs138880 0.505 rs56248708 chr22:50306969 G/A cg02269571 chr22:50332266 NA -0.95 -9.72 -0.47 8.33e-20 Schizophrenia; CRC cis rs9467773 1.000 rs1884946 chr6:26545308 C/G cg09904177 chr6:26538194 HMGN4 0.85 14.88 0.63 1.17e-38 Intelligence (multi-trait analysis); CRC trans rs4295623 0.553 rs11250163 chr8:11596437 G/T cg06636001 chr8:8085503 FLJ10661 0.57 8.91 0.44 3.56e-17 Morning vs. evening chronotype; CRC trans rs6546324 0.625 rs2861700 chr2:67855441 A/G cg00907274 chr3:27498161 SLC4A7 0.49 6.21 0.32 1.59e-9 Endometriosis; CRC cis rs11148252 0.740 rs7981050 chr13:52755149 C/T cg00495681 chr13:53174319 NA 0.56 8.28 0.42 3.09e-15 Lewy body disease; CRC cis rs4743820 0.603 rs1887370 chr9:93927076 G/A cg14446406 chr9:93919335 NA -0.44 -7.7 -0.39 1.56e-13 Ulcerative colitis;Inflammatory bowel disease; CRC cis rs425277 0.583 rs10910046 chr1:2041155 C/T cg19257562 chr1:2043853 PRKCZ 0.38 6.46 0.34 3.74e-10 Height; CRC cis rs4604732 0.588 rs7552461 chr1:247628644 G/A cg12758973 chr1:247694275 LOC148824;OR2C3 0.38 5.75 0.3 2.03e-8 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CRC cis rs6951245 0.935 rs79067319 chr7:1065548 C/T cg22907277 chr7:1156413 C7orf50 0.69 7.25 0.37 3.02e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs62400317 0.762 rs529125 chr6:44797088 C/T cg18551225 chr6:44695536 NA 0.43 5.82 0.31 1.42e-8 Total body bone mineral density; CRC cis rs8177253 0.665 rs8177178 chr3:133463272 G/A cg24879335 chr3:133465180 TF 0.33 5.93 0.31 7.53e-9 Iron status biomarkers; CRC cis rs1580019 0.885 rs1610141 chr7:32498435 C/T cg06627557 chr7:32535165 LSM5;AVL9 0.84 13.27 0.59 1.76e-32 Cognitive ability; CRC cis rs8141529 0.748 rs715531 chr22:29282679 A/G cg15103426 chr22:29168792 CCDC117 0.52 7.29 0.37 2.34e-12 Lymphocyte counts; CRC cis rs734999 0.588 rs10910099 chr1:2533552 G/T cg18854424 chr1:2615690 NA -0.4 -7.67 -0.39 1.91e-13 Ulcerative colitis; CRC cis rs2243480 1.000 rs709607 chr7:65449541 C/G cg18252515 chr7:66147081 NA 0.89 10.4 0.5 4.49e-22 Diabetic kidney disease; CRC cis rs2549003 1.000 rs2070726 chr5:131821738 C/A cg00255919 chr5:131827918 IRF1 0.59 11.92 0.55 1.77e-27 Asthma (sex interaction); CRC cis rs561341 0.941 rs17780086 chr17:30343282 G/A cg12193833 chr17:30244370 NA -0.75 -8.76 -0.44 1.01e-16 Hip circumference adjusted for BMI; CRC cis rs4836694 0.517 rs1017112 chr9:132936804 A/G cg13414629 chr9:132935646 FREQ 0.43 6.28 0.33 1.07e-9 Alzheimer's disease (cognitive decline); CRC trans rs208520 0.661 rs207090 chr6:66783963 T/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.08 -15.36 -0.65 1.56e-40 Exhaled nitric oxide output; CRC cis rs8067545 0.720 rs6587206 chr17:19881587 T/C cg13482628 chr17:19912719 NA 0.4 6.08 0.32 3.35e-9 Schizophrenia; CRC cis rs763121 0.925 rs4821815 chr22:39105707 G/A cg06022373 chr22:39101656 GTPBP1 0.75 12.47 0.57 1.65e-29 Menopause (age at onset); CRC cis rs2404602 0.692 rs4886829 chr15:77091182 G/T cg23625390 chr15:77176239 SCAPER 0.48 6.92 0.36 2.35e-11 Blood metabolite levels; CRC cis rs1799949 0.965 rs4793204 chr17:41279298 A/G cg01879757 chr17:41196368 BRCA1 -0.43 -6.61 -0.34 1.54e-10 Menopause (age at onset); CRC cis rs6499255 1.000 rs8045682 chr16:69786092 C/A cg04110750 chr16:69646130 NFAT5 -0.51 -6.75 -0.35 6.72e-11 IgE levels; CRC cis rs344364 0.511 rs2982453 chr16:1949520 G/A cg00046913 chr16:1877150 HAGH;FAHD1 -0.58 -6.06 -0.32 3.66e-9 Glomerular filtration rate in chronic kidney disease; CRC cis rs755249 0.567 rs4660546 chr1:39679402 T/C cg18385671 chr1:39797026 MACF1 -0.44 -6.23 -0.32 1.42e-9 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs910316 0.935 rs175422 chr14:75627319 T/A cg11812906 chr14:75593930 NEK9 -0.61 -9.45 -0.46 6.78e-19 Height; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg25876406 chr19:33864478 CEBPG 0.41 6.26 0.33 1.17e-9 Intelligence (multi-trait analysis); CRC cis rs6496667 1.000 rs6496668 chr15:90893704 A/T cg04176472 chr15:90893244 GABARAPL3 0.62 8.52 0.43 5.63e-16 Rheumatoid arthritis; CRC cis rs763121 0.853 rs5757231 chr22:39071658 C/T cg06022373 chr22:39101656 GTPBP1 -0.79 -12.44 -0.57 2.14e-29 Menopause (age at onset); CRC cis rs1153858 0.943 rs11070454 chr15:45680252 C/T cg14582100 chr15:45693742 SPATA5L1 0.28 5.77 0.3 1.88e-8 Homoarginine levels; CRC cis rs13108904 0.557 rs1680030 chr4:1245500 A/T cg02018176 chr4:1364513 KIAA1530 -0.61 -9.81 -0.48 4.12e-20 Obesity-related traits; CRC cis rs67311347 1.000 rs10510708 chr3:40404770 A/G cg24209194 chr3:40518798 ZNF619 0.42 6.54 0.34 2.36e-10 Renal cell carcinoma; CRC cis rs736801 0.740 rs12515180 chr5:131785684 C/T cg00255919 chr5:131827918 IRF1 -0.38 -6.43 -0.33 4.57e-10 Breast cancer;Mosquito bite size; CRC cis rs11098499 0.954 rs10031483 chr4:120422636 T/C cg24375607 chr4:120327624 NA 0.48 7.36 0.38 1.5e-12 Corneal astigmatism; CRC cis rs7937682 0.575 rs1346180 chr11:111715570 G/C cg09085632 chr11:111637200 PPP2R1B 0.95 15.88 0.66 1.52e-42 Primary sclerosing cholangitis; CRC cis rs10791323 0.604 rs2723598 chr11:133711652 G/A cg15485101 chr11:133734466 NA 0.45 7.7 0.39 1.65e-13 Childhood ear infection; CRC cis rs4076764 0.914 rs12123378 chr1:163377846 C/T cg24596788 chr1:163392923 NA -0.66 -10.57 -0.5 1.1e-22 Motion sickness; CRC cis rs25422 0.938 rs7356858 chr6:118765814 G/C cg10217327 chr6:118973057 C6orf204 0.51 5.75 0.3 2e-8 Renal cell carcinoma; CRC cis rs7727544 0.904 rs6897575 chr5:131604535 C/T cg22638593 chr5:131593259 PDLIM4 0.36 6.95 0.36 2.01e-11 Blood metabolite levels; CRC cis rs1552172 0.922 rs2231375 chr1:145696694 G/A cg11743829 chr1:145714124 CD160 -0.42 -6.2 -0.32 1.74e-9 Breast cancer; CRC cis rs6088580 0.634 rs6058051 chr20:33044862 G/A cg08999081 chr20:33150536 PIGU 0.61 11.44 0.53 9.33e-26 Glomerular filtration rate (creatinine); CRC cis rs17713451 0.593 rs7788234 chr7:151268657 A/C cg18404559 chr7:151322523 PRKAG2 -0.57 -6.41 -0.33 5.12e-10 Interleukin-4 levels; CRC cis rs2976388 0.566 rs2585141 chr8:143806343 G/A cg04969067 chr8:143858791 LYNX1 -0.43 -6.76 -0.35 6.44e-11 Urinary tract infection frequency; CRC cis rs10865541 0.902 rs12474836 chr2:3418874 A/G cg22182287 chr2:3452347 TTC15 0.38 5.94 0.31 7.44e-9 Obesity-related traits; CRC cis rs12580194 0.593 rs7485053 chr12:55770126 T/C cg19537932 chr12:55886519 OR6C68 -0.7 -9.02 -0.45 1.54e-17 Cancer; CRC trans rs1814175 0.740 rs10839439 chr11:49918240 C/T cg11707556 chr5:10655725 ANKRD33B -0.42 -7.89 -0.4 4.6e-14 Height; CRC cis rs3091242 0.933 rs909833 chr1:25754140 C/G cg20684491 chr1:25596433 NA 0.42 7.29 0.37 2.37e-12 Erythrocyte sedimentation rate; CRC cis rs6940638 0.688 rs6456766 chr6:27019575 G/A cg12292205 chr6:26970375 C6orf41 -0.48 -6.76 -0.35 6.15e-11 Intelligence (multi-trait analysis); CRC cis rs10870270 0.956 rs11146425 chr10:133734261 C/T cg17892150 chr10:133769511 PPP2R2D -0.72 -10.94 -0.52 5.62e-24 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; CRC cis rs116095464 0.614 rs56299325 chr5:220594 C/T cg22496380 chr5:211416 CCDC127 -0.83 -9.55 -0.47 3.03e-19 Breast cancer; CRC cis rs6860806 0.507 rs272892 chr5:131664349 C/T cg22638593 chr5:131593259 PDLIM4 0.38 6.26 0.33 1.19e-9 Breast cancer; CRC cis rs1552244 1.000 rs17032283 chr3:10081545 C/G cg00166722 chr3:10149974 C3orf24 0.68 9.07 0.45 1.08e-17 Alzheimer's disease; CRC cis rs62064224 0.675 rs12150479 chr17:30636200 T/A cg21839984 chr17:30846986 MYO1D -0.33 -5.74 -0.3 2.15e-8 Schizophrenia; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg10657986 chr3:53381858 DCP1A 0.47 6.63 0.34 1.4e-10 Response to antipsychotic treatment; CRC trans rs3749237 0.964 rs11717463 chr3:49808981 C/T cg21659725 chr3:3221576 CRBN 0.53 7.07 0.36 9.56e-12 Resting heart rate; CRC cis rs9903692 0.954 rs4794451 chr17:46184781 A/G cg21215337 chr17:46176117 CBX1 -0.43 -7.95 -0.4 2.95e-14 Pulse pressure; CRC cis rs853679 0.542 rs2295594 chr6:28053097 G/A cg02683197 chr6:28174875 NA 0.81 9.98 0.48 1.15e-20 Depression; CRC cis rs853679 0.542 rs9380063 chr6:28137853 A/G cg03623178 chr6:28175578 NA 0.98 12.66 0.57 3.31e-30 Depression; CRC cis rs732072 0.826 rs617980 chr11:65475503 G/C cg21033440 chr11:65409861 SIPA1 -0.67 -5.7 -0.3 2.7e-8 Inflammatory bowel disease; CRC cis rs6570726 0.791 rs7755253 chr6:145858893 C/G cg23711669 chr6:146136114 FBXO30 0.76 13.16 0.59 4.67e-32 Lobe attachment (rater-scored or self-reported); CRC cis rs704795 0.867 rs7566052 chr2:27628635 A/G cg02592271 chr2:27665507 KRTCAP3 -0.27 -6.23 -0.32 1.44e-9 Menopause (age at onset); CRC cis rs4713118 0.539 rs510987 chr6:27847517 G/A cg21204522 chr6:27730016 NA -0.4 -5.6 -0.3 4.48e-8 Parkinson's disease; CRC cis rs61160187 0.577 rs34741733 chr5:60139548 C/T cg16298547 chr5:60138761 ELOVL7 -0.28 -5.91 -0.31 8.75e-9 Educational attainment (years of education);Educational attainment (college completion); CRC cis rs2153535 0.560 rs9379214 chr6:8480870 T/C cg07606381 chr6:8435919 SLC35B3 0.67 10.69 0.51 4.33e-23 Motion sickness; CRC cis rs2386661 0.784 rs2386652 chr10:5676326 G/A cg26603656 chr10:5671107 NA 0.56 9.2 0.45 4.1e-18 Breast cancer; CRC cis rs67311347 1.000 rs66841330 chr3:40531123 G/A cg09455208 chr3:40491958 NA 0.46 8.62 0.43 2.86e-16 Renal cell carcinoma; CRC cis rs3096299 0.719 rs2353581 chr16:89518908 T/C cg01788221 chr16:89496183 ANKRD11 -0.4 -5.82 -0.31 1.43e-8 Multiple myeloma (IgH translocation); CRC cis rs804280 0.564 rs4639 chr8:11644751 A/G cg12395012 chr8:11607386 GATA4 -0.37 -5.98 -0.31 5.84e-9 Myopia (pathological); CRC trans rs4263408 0.934 rs9683743 chr4:39703194 A/C cg13897947 chr1:113390019 NA -0.39 -6.17 -0.32 1.96e-9 Plasma amyloid beta peptide concentrations (ABx-40); CRC cis rs34526934 0.608 rs7591820 chr2:177028144 G/T cg26754761 chr2:177040938 NA -0.44 -6.62 -0.34 1.46e-10 Obstructive sleep apnea trait (apnea hypopnea index); CRC trans rs2303319 0.504 rs62188988 chr2:162531068 T/C cg18122310 chr12:50236657 BCDIN3D -0.73 -6.42 -0.33 4.82e-10 Cognitive function; CRC cis rs3213545 0.700 rs2260399 chr12:121469653 C/T cg25281562 chr12:121454272 C12orf43 0.39 5.62 0.3 3.99e-8 Subjective well-being;Cardiovascular disease risk factors; CRC cis rs2243480 1.000 rs73142166 chr7:65375832 A/G cg12463550 chr7:65579703 CRCP 0.69 6.42 0.33 4.89e-10 Diabetic kidney disease; CRC cis rs1153858 0.943 rs28605551 chr15:45641720 C/T cg21132104 chr15:45694354 SPATA5L1 0.56 8.29 0.42 2.95e-15 Homoarginine levels; CRC cis rs4689592 0.503 rs4689064 chr4:7055603 A/G cg26116260 chr4:7069785 GRPEL1 -0.87 -10.62 -0.51 7.77e-23 Monocyte percentage of white cells; CRC cis rs9287719 0.934 rs12692418 chr2:10745870 T/C cg00105475 chr2:10696890 NA 0.45 7.15 0.37 5.48e-12 Prostate cancer; CRC cis rs3785574 0.962 rs2584614 chr17:61929445 C/T cg06873352 chr17:61820015 STRADA 0.47 7.33 0.37 1.82e-12 Height; CRC cis rs11098499 0.874 rs12509054 chr4:120115075 A/C cg09307838 chr4:120376055 NA 0.61 8.95 0.44 2.69e-17 Corneal astigmatism; CRC cis rs523522 0.962 rs3213565 chr12:120992401 C/T cg27279351 chr12:120934652 DYNLL1 0.76 10.93 0.52 6.38e-24 High light scatter reticulocyte count; CRC cis rs6502050 0.799 rs12603050 chr17:80104631 A/G cg25804541 chr17:80189381 SLC16A3 -0.31 -5.97 -0.31 6.08e-9 Life satisfaction; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg19853194 chr18:9913725 VAPA 0.49 6.4 0.33 5.37e-10 Thyroid stimulating hormone; CRC cis rs1538970 0.924 rs1494812 chr1:45876999 C/T cg05343316 chr1:45956843 TESK2 0.72 9.7 0.47 1.02e-19 Platelet count; CRC cis rs6951245 1.000 rs79683221 chr7:1096139 A/G cg26224354 chr7:1096374 C7orf50;GPR146 -0.93 -12.11 -0.56 3.59e-28 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs6988636 1.000 rs17323510 chr8:124186089 A/G cg27053337 chr8:124217698 FAM83A -0.44 -6.66 -0.34 1.16e-10 Urinary uromodulin levels; CRC cis rs13256369 1.000 rs873064 chr8:8572380 G/A cg00074818 chr8:8560427 CLDN23 0.42 7.66 0.39 2.09e-13 Obesity-related traits; CRC cis rs9916302 0.706 rs12950186 chr17:37393395 A/C cg00129232 chr17:37814104 STARD3 -0.58 -7.06 -0.36 9.93e-12 Glomerular filtration rate (creatinine); CRC cis rs10504229 0.906 rs114627636 chr8:58173732 C/T cg24829409 chr8:58192753 C8orf71 -0.74 -8.89 -0.44 3.97e-17 Developmental language disorder (linguistic errors); CRC cis rs2075371 1.000 rs2598286 chr7:133976029 G/A cg11752832 chr7:134001865 SLC35B4 0.49 7.53 0.38 4.83e-13 Mean platelet volume; CRC cis rs2739330 0.760 rs5751761 chr22:24243736 A/G cg11905131 chr22:24372483 LOC391322 0.65 9.93 0.48 1.68e-20 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs7615952 0.515 rs7630575 chr3:125682330 A/G cg05084668 chr3:125655381 ALG1L -0.67 -10.35 -0.5 6.29e-22 Blood pressure (smoking interaction); CRC cis rs72772090 0.539 rs11750464 chr5:96113031 C/T cg17330273 chr5:96107758 CAST;ERAP1 0.67 6.53 0.34 2.51e-10 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs13108904 0.840 rs13149790 chr4:1262239 A/G cg21620606 chr4:1342894 KIAA1530 0.38 6.42 0.33 4.82e-10 Obesity-related traits; CRC cis rs11628318 0.563 rs1190344 chr14:103097912 A/G cg12046867 chr14:103022105 NA -0.39 -5.71 -0.3 2.5e-8 Platelet count; CRC cis rs1448094 0.512 rs11832503 chr12:86240797 A/G cg25456477 chr12:86230367 RASSF9 0.32 5.64 0.3 3.58e-8 Major depressive disorder; CRC cis rs143000161 1 rs143000161 chr2:165710540 A/T cg03182029 chr2:165697222 COBLL1 0.98 9.58 0.47 2.49e-19 Heschl's gyrus morphology; CRC cis rs7487075 0.780 rs12320197 chr12:46738883 A/G cg22049899 chr12:47219821 SLC38A4 0.35 7.1 0.36 7.7e-12 Itch intensity from mosquito bite; CRC cis rs9583531 0.600 rs4773241 chr13:111363021 A/G cg24331049 chr13:111365604 ING1 0.6 8.04 0.41 1.68e-14 Coronary artery disease; CRC cis rs9916302 0.851 rs11868029 chr17:37650304 A/G cg03013999 chr17:37608204 MED1 0.43 6.41 0.33 4.96e-10 Glomerular filtration rate (creatinine); CRC cis rs9487051 0.704 rs1741930 chr6:109519797 T/A cg21918786 chr6:109611834 NA -0.35 -6.05 -0.32 3.9e-9 Reticulocyte fraction of red cells; CRC cis rs514406 0.661 rs550561 chr1:53375134 C/T cg08859206 chr1:53392774 SCP2 -0.6 -9.27 -0.46 2.46e-18 Monocyte count; CRC cis rs2070677 1.000 rs2070677 chr10:135351174 A/T cg20169779 chr10:135381914 SYCE1 -0.78 -11.46 -0.53 8.24e-26 Gout; CRC cis rs11585357 0.895 rs72646798 chr1:17614422 C/T cg08277548 chr1:17600880 PADI3 -0.89 -11.28 -0.53 3.61e-25 Hair shape; CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg04232466 chr8:21988724 HR -0.52 -6.43 -0.33 4.49e-10 Diisocyanate-induced asthma; CRC cis rs990171 1.000 rs2110734 chr2:103052206 C/T cg03938978 chr2:103052716 IL18RAP 0.45 5.8 0.3 1.53e-8 Lymphocyte counts; CRC cis rs6693567 0.526 rs3818978 chr1:150266338 T/A cg04165759 chr1:150448943 RPRD2 -0.36 -5.94 -0.31 7.41e-9 Migraine; CRC cis rs9894429 0.789 rs8074989 chr17:79598728 G/C cg21984481 chr17:79567631 NPLOC4 -0.57 -10.89 -0.51 8.51e-24 Eye color traits; CRC cis rs7208859 0.573 rs73267829 chr17:29003939 G/A cg19761014 chr17:28927070 LRRC37B2 0.59 5.89 0.31 9.68e-9 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs2708977 0.698 rs772159 chr2:97036439 G/A cg23100626 chr2:96804247 ASTL 0.23 5.88 0.31 9.81e-9 Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes; CRC cis rs17253792 0.822 rs76612185 chr14:56037706 T/C cg01858014 chr14:56050164 KTN1 -0.88 -6.75 -0.35 6.66e-11 Putamen volume; CRC cis rs4713118 0.738 rs200465 chr6:27757654 T/A cg03623178 chr6:28175578 NA 0.7 9.29 0.46 2.17e-18 Parkinson's disease; CRC trans rs79976124 0.842 rs7760550 chr6:66628788 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.73 9.15 0.45 6.1e-18 Type 2 diabetes; CRC trans rs2727020 0.755 rs652655 chr11:49251293 G/A cg15704280 chr7:45808275 SEPT13 0.88 15.31 0.65 2.55e-40 Coronary artery disease; CRC cis rs6570726 0.738 rs6917199 chr6:145918320 G/A cg23711669 chr6:146136114 FBXO30 0.76 13.18 0.59 3.84e-32 Lobe attachment (rater-scored or self-reported); CRC cis rs9649213 0.614 rs59120980 chr7:98017730 G/A cg09267113 chr7:98030324 BAIAP2L1 -0.94 -12.65 -0.57 3.73e-30 Prostate cancer (SNP x SNP interaction); CRC cis rs7107174 1.000 rs10793297 chr11:78009660 T/C cg02023728 chr11:77925099 USP35 0.52 7.41 0.38 1.09e-12 Testicular germ cell tumor; CRC cis rs78456975 0.943 rs13391932 chr2:1577679 T/C cg12573674 chr2:1569213 NA -0.68 -7.74 -0.39 1.22e-13 Placebo response in major depressive disorder (% change in symptom score); CRC cis rs1200821 0.535 rs1208784 chr10:37768433 A/G cg00409905 chr10:38381863 ZNF37A -0.48 -7.02 -0.36 1.25e-11 Hemostatic factors and hematological phenotypes; CRC cis rs7264396 0.676 rs6060730 chr20:34558503 G/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.61 -9.83 -0.48 3.75e-20 Total cholesterol levels; CRC cis rs17270561 0.609 rs1165211 chr6:25800922 T/C cg16482183 chr6:26056742 HIST1H1C 0.59 7.97 0.4 2.64e-14 Iron status biomarkers; CRC trans rs247929 0.642 rs11525670 chr12:46451692 A/G cg11832793 chr4:24212454 NA 0.36 5.99 0.31 5.63e-9 Educational attainment; CRC cis rs73200209 0.744 rs56350518 chr12:116556775 A/G cg01776926 chr12:116560359 MED13L -0.62 -7.42 -0.38 9.81e-13 Total body bone mineral density; CRC cis rs4750440 0.706 rs10796148 chr10:14016900 G/A cg00551146 chr10:14014579 FRMD4A 0.35 5.71 0.3 2.57e-8 Adiponectin levels; CRC cis rs73206853 0.841 rs74503171 chr12:111061652 A/G cg12870014 chr12:110450643 ANKRD13A 0.72 7.58 0.39 3.64e-13 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC cis rs10751667 0.580 rs10751664 chr11:927077 T/G cg01483505 chr11:975446 AP2A2 0.43 6.87 0.35 3.26e-11 Alzheimer's disease (late onset); CRC cis rs56104184 0.723 rs116909499 chr19:49407733 C/T cg15549821 chr19:49342101 PLEKHA4 -0.51 -5.74 -0.3 2.13e-8 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; CRC trans rs208520 0.661 rs7740835 chr6:66865548 G/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.05 -14.8 -0.63 2.42e-38 Exhaled nitric oxide output; CRC cis rs2839186 0.770 rs2280956 chr21:47642323 C/G cg13126279 chr21:47581558 C21orf56 0.51 8.36 0.42 1.74e-15 Testicular germ cell tumor; CRC cis rs1568889 0.938 rs1464898 chr11:28034748 A/G cg06544937 chr11:28130018 METT5D1;KIF18A 0.79 11.19 0.53 7.53e-25 Bipolar disorder; CRC cis rs11628318 0.614 rs11847932 chr14:103185435 T/G cg23461800 chr14:103021989 NA 0.67 7.58 0.39 3.58e-13 Platelet count; CRC cis rs12530845 0.623 rs73721681 chr7:135361917 A/G cg23117316 chr7:135346802 PL-5283 -0.49 -6.24 -0.33 1.35e-9 Red blood cell traits; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg21411490 chr22:31739936 PATZ1 0.35 6.07 0.32 3.46e-9 Intelligence (multi-trait analysis); CRC trans rs11148252 0.532 rs9536190 chr13:53181044 T/C cg18335740 chr13:41363409 SLC25A15 0.96 17.78 0.7 4.99e-50 Lewy body disease; CRC cis rs34172651 0.917 rs12599173 chr16:24823619 T/C cg00339695 chr16:24857497 SLC5A11 0.25 5.89 0.31 9.79e-9 Intelligence (multi-trait analysis); CRC cis rs6502050 0.835 rs7501527 chr17:80099355 A/C cg19223190 chr17:80058835 NA 0.39 6.16 0.32 2.11e-9 Life satisfaction; CRC cis rs6940638 0.531 rs12211984 chr6:26986054 G/C cg12292205 chr6:26970375 C6orf41 0.56 9.32 0.46 1.78e-18 Intelligence (multi-trait analysis); CRC cis rs2075371 0.932 rs2544215 chr7:133987896 T/C cg02659138 chr7:134003124 SLC35B4 0.38 6.53 0.34 2.52e-10 Mean platelet volume; CRC cis rs2645694 0.626 rs2703140 chr4:77830057 C/G cg18351406 chr4:77819688 ANKRD56 0.5 7.58 0.39 3.58e-13 Emphysema distribution in smoking; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg07038191 chr16:29801882 KIF22 0.4 6.27 0.33 1.15e-9 Liver disease severity in Alagille syndrome; CRC cis rs3733585 0.699 rs1079128 chr4:9951221 T/C cg00071950 chr4:10020882 SLC2A9 -0.56 -10.03 -0.48 7.78e-21 Cleft plate (environmental tobacco smoke interaction); CRC cis rs710216 0.536 rs710221 chr1:43414200 G/A cg07803811 chr1:43423981 SLC2A1 0.42 6.05 0.32 4.03e-9 Red cell distribution width; CRC cis rs10791097 0.653 rs11222362 chr11:130731425 T/C cg12179176 chr11:130786555 SNX19 0.67 10.78 0.51 2.04e-23 Autism spectrum disorder or schizophrenia;Schizophrenia; CRC cis rs9318086 0.901 rs7336730 chr13:24452104 T/G cg25267304 chr13:24462978 PCOTH;MIPEP -0.62 -10.33 -0.49 7.59e-22 Myopia (pathological); CRC cis rs7223966 1.000 rs9895920 chr17:61852719 T/C cg23090583 chr17:61904693 PSMC5;FTSJ3 0.46 5.81 0.3 1.51e-8 Hip circumference adjusted for BMI;Body mass index; CRC cis rs7917772 0.636 rs7088981 chr10:104520423 T/C cg04362960 chr10:104952993 NT5C2 0.46 6.14 0.32 2.4e-9 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC cis rs477692 0.905 rs489966 chr10:131422115 C/G cg05714579 chr10:131428358 MGMT -0.62 -9.01 -0.45 1.66e-17 Response to temozolomide; CRC cis rs3087591 0.960 rs2953009 chr17:29498387 A/C cg24425628 chr17:29625626 OMG;NF1 0.86 16.18 0.67 9.55e-44 Hip circumference; CRC cis rs1046896 0.519 rs9900369 chr17:80829807 G/A cg19046167 chr17:80928561 B3GNTL1 0.51 7.14 0.37 6.01e-12 Glycated hemoglobin levels; CRC trans rs877282 0.629 rs78997110 chr10:764388 A/G cg22713356 chr15:30763199 NA 1.28 14.21 0.62 4.48e-36 Uric acid levels; CRC cis rs7786808 0.552 rs2878456 chr7:158182129 A/T cg01191920 chr7:158217561 PTPRN2 -0.7 -11.19 -0.53 7.26e-25 Obesity-related traits; CRC cis rs2836974 0.899 rs35774464 chr21:40580169 G/A cg11890956 chr21:40555474 PSMG1 1.01 16.01 0.66 4.5e-43 Cognitive function; CRC cis rs4713118 0.669 rs200997 chr6:27811815 G/A cg03623178 chr6:28175578 NA 0.68 9.59 0.47 2.31e-19 Parkinson's disease; CRC cis rs4073416 0.542 rs2183277 chr14:66035429 T/C cg03016385 chr14:66212404 NA -0.45 -6.19 -0.32 1.78e-9 N-glycan levels; CRC cis rs2976388 0.590 rs10087426 chr8:143814554 G/A cg10596483 chr8:143751796 JRK -0.43 -6.12 -0.32 2.65e-9 Urinary tract infection frequency; CRC cis rs939584 0.932 rs2867111 chr2:651286 A/C cg03610516 chr2:642275 NA -0.42 -5.89 -0.31 9.71e-9 Body mass index; CRC cis rs4700695 0.925 rs6878011 chr5:65392465 G/A cg21114390 chr5:65439923 SFRS12 -0.6 -6.98 -0.36 1.6e-11 Facial morphology (factor 19); CRC cis rs8180040 0.966 rs11711824 chr3:47468261 C/T cg10298567 chr3:47292165 KIF9 -0.36 -5.84 -0.31 1.25e-8 Colorectal cancer; CRC cis rs9487051 0.724 rs11751953 chr6:109635986 G/A cg01475377 chr6:109611718 NA -0.38 -5.69 -0.3 2.86e-8 Reticulocyte fraction of red cells; CRC cis rs7811142 0.943 rs67196635 chr7:100025564 T/C cg00814883 chr7:100076585 TSC22D4 -0.72 -9.44 -0.46 7.01e-19 Platelet count; CRC cis rs35110281 0.811 rs7275705 chr21:45056453 G/C cg04455712 chr21:45112962 RRP1B 0.41 8.13 0.41 8.94e-15 Mean corpuscular volume; CRC cis rs9322193 0.923 rs9383812 chr6:150033491 C/T cg04369109 chr6:150039330 LATS1 -0.42 -5.79 -0.3 1.6e-8 Lung cancer; CRC cis rs7769051 1.000 rs9493445 chr6:133125409 C/T cg22852734 chr6:133119734 C6orf192 0.98 12.25 0.56 1.12e-28 Type 2 diabetes nephropathy; CRC cis rs7605827 0.930 rs3792579 chr2:15534723 A/G cg19274914 chr2:15703543 NA 0.39 5.88 0.31 9.87e-9 Educational attainment (years of education); CRC cis rs12893668 0.572 rs4906356 chr14:104138701 C/T cg01849466 chr14:104193079 ZFYVE21 -0.4 -5.98 -0.31 5.95e-9 Reticulocyte count; CRC cis rs7412746 0.611 rs7556661 chr1:150892009 C/T cg18016565 chr1:150552671 MCL1 0.42 6.02 0.31 4.66e-9 Melanoma; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg27529569 chr19:2977348 TLE6 0.47 6.53 0.34 2.5e-10 Anxiety disorder; CRC cis rs9611565 0.649 rs5751108 chr22:41858035 T/C cg03806693 chr22:41940476 POLR3H 1.04 13.3 0.59 1.34e-32 Vitiligo; CRC cis rs561341 1.000 rs72825740 chr17:30338356 A/G cg23018236 chr17:30244563 NA -0.68 -8.1 -0.41 1.12e-14 Hip circumference adjusted for BMI; CRC cis rs10504229 0.906 rs7842855 chr8:58167718 G/C cg24829409 chr8:58192753 C8orf71 -0.56 -9.94 -0.48 1.53e-20 Developmental language disorder (linguistic errors); CRC cis rs561341 1.000 rs510264 chr17:30323414 A/G cg00745463 chr17:30367425 LRRC37B -0.88 -9.6 -0.47 2.1e-19 Hip circumference adjusted for BMI; CRC cis rs7527798 0.592 rs11118282 chr1:207832402 G/A cg09232269 chr1:207846808 CR1L -0.44 -7.15 -0.37 5.54e-12 Erythrocyte sedimentation rate; CRC cis rs10504229 0.683 rs56196593 chr8:58141898 G/A cg22535103 chr8:58192502 C8orf71 -0.7 -9.4 -0.46 9.29e-19 Developmental language disorder (linguistic errors); CRC cis rs9733 0.593 rs10888384 chr1:150574256 C/T cg10589385 chr1:150898437 SETDB1 -0.26 -5.64 -0.3 3.65e-8 Tonsillectomy; CRC cis rs7666738 0.716 rs28792413 chr4:99083707 G/A cg17366294 chr4:99064904 C4orf37 0.35 5.77 0.3 1.82e-8 Colonoscopy-negative controls vs population controls; CRC cis rs6761276 0.649 rs12711751 chr2:113837765 T/G cg09040174 chr2:113837401 NA 0.59 8.88 0.44 4.43e-17 Protein quantitative trait loci; CRC trans rs2797160 1.000 rs2797161 chr6:126010789 A/G cg05039488 chr6:79577232 IRAK1BP1 0.5 7.51 0.38 5.8e-13 Endometrial cancer; CRC cis rs9649213 0.593 rs6465662 chr7:97917801 A/T cg21770322 chr7:97807741 LMTK2 0.54 9.08 0.45 1.02e-17 Prostate cancer (SNP x SNP interaction); CRC trans rs2303319 0.504 rs12467625 chr2:162603387 C/A cg20024234 chr21:43431083 ZNF295 -0.66 -5.99 -0.31 5.57e-9 Cognitive function; CRC cis rs6541297 1.000 rs6681042 chr1:230278979 G/A cg20703242 chr1:230279135 GALNT2 0.52 8.02 0.4 1.82e-14 Coronary artery disease; CRC cis rs4664293 0.605 rs7556888 chr2:160540261 T/C cg08347373 chr2:160653686 CD302 0.36 5.92 0.31 8.09e-9 Monocyte percentage of white cells; CRC cis rs10771431 0.597 rs10843144 chr12:9357577 C/T cg08997352 chr12:9597637 DDX12 -0.44 -6.55 -0.34 2.19e-10 Breast size; CRC cis rs9322817 0.691 rs9377679 chr6:105345036 C/T cg02098413 chr6:105308735 HACE1 0.45 9.05 0.45 1.23e-17 Thyroid stimulating hormone; CRC cis rs12824058 0.831 rs7310433 chr12:130809289 C/T cg24838063 chr12:130822603 PIWIL1 0.58 9.77 0.47 5.67e-20 Menopause (age at onset); CRC cis rs10504229 0.953 rs6991035 chr8:58183374 C/T cg02290350 chr8:58132656 NA -0.42 -5.96 -0.31 6.62e-9 Developmental language disorder (linguistic errors); CRC cis rs58688157 0.639 rs60568231 chr11:575553 A/T cg07212818 chr11:638076 DRD4 -0.46 -5.96 -0.31 6.32e-9 Systemic lupus erythematosus; CRC cis rs4808199 0.947 rs751858 chr19:19602821 G/C cg03709012 chr19:19516395 GATAD2A 1.0 12.12 0.56 3.24e-28 Nonalcoholic fatty liver disease; CRC cis rs4713118 0.869 rs9295742 chr6:27702832 G/A cg26587870 chr6:27730563 NA -0.43 -6.72 -0.35 8.04e-11 Parkinson's disease; CRC cis rs2404602 0.716 rs12437627 chr15:76845050 T/C cg00316803 chr15:76480434 C15orf27 -0.35 -5.81 -0.31 1.46e-8 Blood metabolite levels; CRC cis rs1799949 0.965 rs799917 chr17:41244936 G/A cg19454999 chr17:41278357 BRCA1;NBR2 0.4 6.1 0.32 3.03e-9 Menopause (age at onset); CRC cis rs9527 0.521 rs12259163 chr10:104961477 A/G cg15744005 chr10:104629667 AS3MT -0.31 -5.92 -0.31 7.98e-9 Arsenic metabolism; CRC cis rs7586879 0.575 rs6744205 chr2:25133148 T/C cg04586622 chr2:25135609 ADCY3 -0.55 -10.09 -0.49 4.8e-21 Body mass index; CRC cis rs644799 0.965 rs11021313 chr11:95506907 G/C cg03916912 chr11:95522834 CEP57;FAM76B 0.96 17.82 0.7 3.44e-50 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs2404602 0.716 rs117129193 chr15:76656803 A/G cg22467129 chr15:76604101 ETFA -0.46 -7.78 -0.39 9.49e-14 Blood metabolite levels; CRC cis rs3767633 0.858 rs7532448 chr1:161862745 C/T cg09175582 chr1:161736000 ATF6 0.7 6.29 0.33 1.03e-9 IgG glycosylation; CRC cis rs9640161 0.750 rs11769348 chr7:150026753 C/T cg13722127 chr7:150037890 RARRES2 -0.49 -7.77 -0.39 1.04e-13 Blood protein levels;Circulating chemerin levels; CRC trans rs11105468 1.000 rs10777206 chr12:90260046 C/T cg23572944 chr11:60720130 SLC15A3 -0.45 -6.38 -0.33 5.97e-10 Febrile seizures;Febrile seizures (MMR vaccine-related);Febrile seizures (MMR vaccine-unrelated); CRC cis rs17711722 0.640 rs13237956 chr7:65318029 G/A cg00343986 chr7:65444356 GUSB 0.55 8.4 0.42 1.32e-15 Calcium levels; CRC cis rs9399135 0.967 rs13218642 chr6:135309940 A/G cg22676075 chr6:135203613 NA 0.44 6.8 0.35 4.89e-11 Red blood cell count; CRC cis rs2303745 0.589 rs1864115 chr19:17393327 G/C cg02221750 chr19:17393354 ANKLE1 -0.43 -6.58 -0.34 1.82e-10 Systemic lupus erythematosus; CRC cis rs965469 1.000 rs6051809 chr20:3352551 A/C cg25506879 chr20:3388711 C20orf194 -0.4 -5.83 -0.31 1.35e-8 IFN-related cytopenia; CRC cis rs34779708 0.931 rs2001893 chr10:35300623 G/A cg03585969 chr10:35415529 CREM 0.6 8.14 0.41 8.07e-15 Inflammatory bowel disease;Crohn's disease; CRC cis rs4819052 0.851 rs2838826 chr21:46655785 A/G cg02159808 chr21:46707872 POFUT2;LOC642852 0.5 6.32 0.33 8.74e-10 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs10078 0.559 rs2671891 chr5:456386 A/G cg08916839 chr5:415575 AHRR 0.83 8.44 0.42 1.04e-15 Fat distribution (HIV); CRC cis rs2066819 1.000 rs58852079 chr12:56706922 A/C cg26714650 chr12:56694279 CS -1.39 -11.42 -0.53 1.14e-25 Psoriasis vulgaris; CRC cis rs6076065 0.723 rs2251145 chr20:23399998 G/A cg11657817 chr20:23433608 CST11 0.43 6.4 0.33 5.36e-10 Facial morphology (factor 15, philtrum width); CRC cis rs2204008 0.548 rs2320740 chr12:38166421 G/A cg13010199 chr12:38710504 ALG10B 0.46 5.91 0.31 8.63e-9 Bladder cancer; CRC cis rs12594515 1.000 rs8039622 chr15:45986431 A/G cg19682013 chr15:45996608 NA 0.32 6.71 0.35 8.73e-11 Waist circumference;Weight; CRC cis rs9326248 0.954 rs521171 chr11:117064693 C/G cg11861562 chr11:117069780 TAGLN 0.41 9.25 0.45 2.85e-18 Blood protein levels; CRC cis rs60843830 1.000 rs3791223 chr2:222336 T/C cg00108164 chr2:264199 ACP1;SH3YL1 0.63 9.81 0.48 4.17e-20 Spherical equivalent (joint analysis main effects and education interaction); CRC cis rs6772849 0.804 rs4857920 chr3:128407623 C/T cg08795948 chr3:128337044 NA 0.34 5.75 0.3 2.07e-8 Monocyte percentage of white cells;Monocyte count; CRC cis rs7727544 0.716 rs4705926 chr5:131561758 C/T cg09877947 chr5:131593287 PDLIM4 0.35 6.36 0.33 6.71e-10 Blood metabolite levels; CRC cis rs9894429 0.646 rs8079963 chr17:79603285 C/T cg21028142 chr17:79581711 NPLOC4 0.34 7.17 0.37 5.11e-12 Eye color traits; CRC cis rs9902453 0.765 rs3102560 chr17:28029938 T/C cg26525008 chr17:28256777 EFCAB5;SSH2 0.71 12.03 0.55 7.05e-28 Coffee consumption (cups per day); CRC cis rs6570726 0.764 rs448258 chr6:145869145 C/A cg23711669 chr6:146136114 FBXO30 0.76 13.25 0.59 2.17e-32 Lobe attachment (rater-scored or self-reported); CRC cis rs35306767 0.953 rs10904581 chr10:964685 A/T cg20503657 chr10:835505 NA 0.79 10.06 0.49 6.22e-21 Eosinophil percentage of granulocytes; CRC cis rs394563 0.622 rs237024 chr6:149721965 T/C cg03678062 chr6:149772716 ZC3H12D -0.37 -6.72 -0.35 7.94e-11 Dupuytren's disease; CRC cis rs4654899 0.758 rs12078457 chr1:21397071 C/T cg02927042 chr1:21476669 EIF4G3 -0.4 -6.23 -0.32 1.4e-9 Superior frontal gyrus grey matter volume; CRC cis rs7474896 0.515 rs624359 chr10:38299132 T/C cg25427524 chr10:38739819 LOC399744 0.6 7.34 0.37 1.73e-12 Obesity (extreme); CRC cis rs2252521 0.524 rs317745 chr7:29068114 T/C cg11728747 chr7:29037910 CPVL -0.5 -7.21 -0.37 3.86e-12 Cognitive performance; CRC cis rs10426930 0.621 rs10409229 chr19:5009545 C/T cg18473234 chr19:5097819 KDM4B 0.5 5.73 0.3 2.31e-8 Monocyte percentage of white cells; CRC cis rs6121246 0.559 rs6087771 chr20:30306724 A/G cg13852791 chr20:30311386 BCL2L1 0.8 15.08 0.64 2.03e-39 Mean corpuscular hemoglobin; CRC cis rs2019137 0.539 rs6755040 chr2:113981137 T/C cg21610815 chr2:113994035 PAX8;LOC654433;LOC440839 0.57 8.59 0.43 3.61e-16 Lymphocyte counts; CRC cis rs1552244 1.000 rs56270432 chr3:10087517 G/C cg13047869 chr3:10149882 C3orf24 0.53 7.31 0.37 2.04e-12 Alzheimer's disease; CRC cis rs6951245 0.745 rs79788515 chr7:1101079 C/T cg21664854 chr7:1097933 C7orf50;GPR146 0.8 9.13 0.45 7.19e-18 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs806215 1.000 rs2106186 chr7:127241352 G/C cg25922125 chr7:127225783 GCC1 0.61 6.78 0.35 5.54e-11 Type 2 diabetes; CRC cis rs9487051 0.676 rs6910119 chr6:109599263 A/G cg12927641 chr6:109611667 NA -0.36 -6.32 -0.33 8.39e-10 Reticulocyte fraction of red cells; CRC cis rs5750830 0.649 rs5750811 chr22:39793066 G/T cg25956985 chr22:39795188 MAP3K7IP1 0.47 6.49 0.34 3.17e-10 Intelligence (multi-trait analysis); CRC cis rs2075371 0.863 rs1421479 chr7:133949345 T/G cg02659138 chr7:134003124 SLC35B4 0.39 6.62 0.34 1.46e-10 Mean platelet volume; CRC cis rs67340775 0.541 rs200974 chr6:27855845 A/G cg15845792 chr6:28175446 NA 0.85 8.72 0.43 1.38e-16 Lung cancer in ever smokers; CRC cis rs798554 0.704 rs709282 chr7:2769921 G/A cg19717773 chr7:2847554 GNA12 -0.39 -6.32 -0.33 8.45e-10 Height; CRC cis rs875971 0.862 rs7809814 chr7:65615397 G/A cg00343986 chr7:65444356 GUSB -0.42 -5.93 -0.31 7.79e-9 Aortic root size; CRC cis rs9409565 0.559 rs9409762 chr9:97215040 A/C cg04523069 chr9:97136363 HIATL1 0.43 6.02 0.32 4.58e-9 Colorectal cancer (alcohol consumption interaction); CRC cis rs8177253 1.000 rs6762719 chr3:133480817 A/G cg08048268 chr3:133502702 NA -0.37 -6.93 -0.36 2.22e-11 Iron status biomarkers; CRC cis rs2404602 0.647 rs11637096 chr15:76931102 T/C cg03037974 chr15:76606532 NA -0.53 -7.62 -0.39 2.7e-13 Blood metabolite levels; CRC cis rs798554 0.757 rs1182171 chr7:2878510 A/G cg04166393 chr7:2884313 GNA12 0.46 6.26 0.33 1.23e-9 Height; CRC cis rs10461617 0.617 rs79742142 chr5:56104377 A/G cg03609598 chr5:56110824 MAP3K1 -0.83 -10.0 -0.48 9.78e-21 Type 2 diabetes; CRC cis rs1552244 0.816 rs9847657 chr3:10173492 G/T cg02579736 chr3:10068473 FANCD2;CIDECP 0.81 11.16 0.52 9.46e-25 Alzheimer's disease; CRC cis rs728616 0.867 rs117139504 chr10:81734207 C/A cg11900509 chr10:81946545 ANXA11 -0.68 -6.82 -0.35 4.39e-11 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs1728785 1.000 rs7118 chr16:68600855 G/T cg02972257 chr16:68554789 NA -0.6 -7.52 -0.38 5.1e-13 Ulcerative colitis; CRC trans rs4714291 0.832 rs6936016 chr6:40097013 A/G cg02267698 chr19:7991119 CTXN1 -0.51 -6.92 -0.36 2.37e-11 Strep throat; CRC cis rs34375054 0.624 rs7295689 chr12:125680922 T/G cg02766259 chr12:125626809 AACS -0.47 -7.64 -0.39 2.44e-13 Post bronchodilator FEV1/FVC ratio; CRC cis rs4925325 1.000 rs4925325 chr20:60514224 G/A cg12751644 chr20:60527061 NA 0.51 7.5 0.38 5.93e-13 Obesity-related traits; CRC trans rs1005277 0.522 rs200943 chr10:38148730 A/G cg23533926 chr12:111358616 MYL2 -0.45 -6.65 -0.34 1.23e-10 Extrinsic epigenetic age acceleration; CRC cis rs8078723 0.866 rs7502514 chr17:38188844 A/G cg17467752 chr17:38218738 THRA -0.77 -12.69 -0.57 2.55e-30 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); CRC trans rs7618501 0.571 rs2240329 chr3:50107512 G/A cg21659725 chr3:3221576 CRBN -0.54 -8.56 -0.43 4.45e-16 Intelligence (multi-trait analysis); CRC cis rs3733585 0.638 rs17185835 chr4:9958180 T/G cg00071950 chr4:10020882 SLC2A9 -0.54 -9.58 -0.47 2.54e-19 Cleft plate (environmental tobacco smoke interaction); CRC cis rs939658 1.000 rs939658 chr15:79451869 A/G cg17916960 chr15:79447300 NA 0.44 7.18 0.37 4.75e-12 Refractive error; CRC cis rs12681287 0.608 rs1135451 chr8:87483608 T/C cg27223183 chr8:87520930 FAM82B -0.53 -7.52 -0.38 5.31e-13 Caudate activity during reward; CRC cis rs4664293 0.764 rs1425044 chr2:160474937 C/T cg08347373 chr2:160653686 CD302 -0.45 -7.83 -0.4 6.65e-14 Monocyte percentage of white cells; CRC cis rs4665809 0.941 rs1470096 chr2:26311482 T/C cg04944784 chr2:26401820 FAM59B -0.66 -8.13 -0.41 8.57e-15 Gut microbiome composition (summer); CRC cis rs6120849 0.754 rs1885116 chr20:33600560 A/G cg08999081 chr20:33150536 PIGU 0.46 5.98 0.31 5.87e-9 Protein C levels; CRC cis rs477895 0.938 rs28395875 chr11:64024048 G/C cg19465662 chr11:63993652 NUDT22;TRPT1 0.71 7.47 0.38 7.26e-13 Mean platelet volume; CRC cis rs4466137 0.868 rs4703962 chr5:82999808 A/G cg16102102 chr5:83017553 HAPLN1 -0.55 -7.93 -0.4 3.42e-14 Prostate cancer; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg22269526 chr2:47630224 MSH2 0.39 5.98 0.31 5.95e-9 Liver disease severity in Alagille syndrome; CRC trans rs2727020 0.612 rs603672 chr11:49234566 T/A cg15704280 chr7:45808275 SEPT13 0.84 14.14 0.61 8.83e-36 Coronary artery disease; CRC cis rs12024301 0.557 rs6658393 chr1:183621477 A/G cg11505048 chr1:183622726 RGL1;APOBEC4 0.81 7.14 0.37 5.93e-12 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs11190604 1.000 rs2489036 chr10:102319581 A/G cg16342193 chr10:102329863 NA -0.34 -5.79 -0.3 1.67e-8 Palmitoleic acid (16:1n-7) levels; CRC cis rs17384381 0.953 rs12717763 chr1:85808164 A/T cg16011679 chr1:85725395 C1orf52 0.67 6.93 0.36 2.21e-11 Lobe attachment (rater-scored or self-reported); CRC cis rs12711979 0.566 rs1111281 chr2:3855896 C/T cg17052675 chr2:3827356 NA -0.37 -5.87 -0.31 1.07e-8 Itch intensity from mosquito bite adjusted by bite size; CRC cis rs4908760 0.899 rs61783642 chr1:8591397 T/C cg20416874 chr1:8611966 RERE -0.45 -6.44 -0.33 4.15e-10 Vitiligo; CRC cis rs13108904 0.967 rs12502916 chr4:1276349 G/A cg21620606 chr4:1342894 KIAA1530 -0.34 -5.93 -0.31 7.65e-9 Obesity-related traits; CRC cis rs172166 0.694 rs1225716 chr6:28113746 A/C cg12172441 chr6:28176163 NA 0.54 7.32 0.37 1.87e-12 Cardiac Troponin-T levels; CRC cis rs10193935 0.901 rs7601905 chr2:42494144 A/G cg27598129 chr2:42591480 NA -0.5 -6.15 -0.32 2.21e-9 Colonoscopy-negative controls vs population controls; CRC cis rs3858526 0.883 rs11039686 chr11:5948725 T/C cg05234568 chr11:5960015 NA -0.53 -7.21 -0.37 3.91e-12 DNA methylation (variation); CRC cis rs12142240 0.583 rs5013330 chr1:46815154 G/A cg14993813 chr1:46806288 NSUN4 -0.5 -6.4 -0.33 5.38e-10 Menopause (age at onset); CRC cis rs4594175 0.926 rs113095693 chr14:51600511 G/C cg23942311 chr14:51606299 NA 0.67 11.22 0.53 5.87e-25 Cancer; CRC trans rs7618501 1.000 rs695238 chr3:49869158 A/C cg21582582 chr3:182698605 DCUN1D1 0.54 7.98 0.4 2.43e-14 Intelligence (multi-trait analysis); CRC cis rs4588572 0.643 rs1560196 chr5:77701982 G/C cg11547950 chr5:77652471 NA 0.53 7.44 0.38 8.94e-13 Triglycerides; CRC cis rs8072100 1.000 rs3809868 chr17:45750596 G/A cg08085267 chr17:45401833 C17orf57 0.66 10.65 0.51 5.92e-23 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs9420 0.961 rs7117205 chr11:57641883 A/G cg23127183 chr11:57508653 C11orf31 -0.53 -7.1 -0.36 7.6e-12 Schizophrenia; CRC cis rs2976388 0.590 rs3758082 chr8:143824483 A/G cg15511327 chr8:143859410 LYNX1 -0.39 -6.52 -0.34 2.65e-10 Urinary tract infection frequency; CRC cis rs9611565 0.559 rs9611619 chr22:41986714 C/T cg06634786 chr22:41940651 POLR3H -0.62 -6.38 -0.33 6.07e-10 Vitiligo; CRC cis rs3820068 0.580 rs7512308 chr1:16006604 C/A cg13390004 chr1:15929781 NA 0.51 6.96 0.36 1.88e-11 Systolic blood pressure; CRC cis rs6964587 1.000 rs12333563 chr7:91667326 G/A cg17063962 chr7:91808500 NA 0.8 14.23 0.62 3.81e-36 Breast cancer; CRC cis rs853679 0.517 rs9393893 chr6:28109262 T/C cg12273811 chr6:28175739 NA 0.73 9.16 0.45 5.8e-18 Depression; CRC cis rs11677416 1.000 rs2856836 chr2:113532083 A/G cg27083787 chr2:113543245 IL1A 0.47 6.67 0.35 1.08e-10 Response to antipsychotic treatment in schizophrenia (working memory); CRC cis rs2012796 1.000 rs10450894 chr14:81825172 T/A cg02996355 chr14:81879375 NA 0.51 7.61 0.39 2.89e-13 Night sleep phenotypes; CRC cis rs1018836 0.663 rs3950221 chr8:91478108 G/A cg16814680 chr8:91681699 NA -0.68 -10.13 -0.49 3.7e-21 Ejection fraction in Tripanosoma cruzi seropositivity; CRC cis rs2249625 0.523 rs2463702 chr6:72853778 A/G cg18830697 chr6:72922368 RIMS1 0.3 5.95 0.31 6.71e-9 Acute urticaria and angioedema (non-steroidal anti-inflammatory drug-induced); CRC cis rs9910055 0.607 rs13726 chr17:42239561 C/T cg19774624 chr17:42201019 HDAC5 -0.68 -10.25 -0.49 1.44e-21 Total body bone mineral density; CRC cis rs453301 0.686 rs11785819 chr8:8870378 T/G cg08975724 chr8:8085496 FLJ10661 -0.39 -5.77 -0.3 1.79e-8 Joint mobility (Beighton score); CRC cis rs9399135 0.967 rs4896121 chr6:135293645 T/C cg24558204 chr6:135376177 HBS1L 0.5 7.92 0.4 3.76e-14 Red blood cell count; CRC cis rs9486715 0.867 rs9384628 chr6:96960232 T/C cg06623918 chr6:96969491 KIAA0776 1.03 20.52 0.75 7.72e-61 Headache; CRC cis rs7224314 1.000 rs7224314 chr17:65386214 A/C cg01507342 chr17:65387096 PITPNC1 -0.54 -7.88 -0.4 4.77e-14 Diisocyanate-induced asthma; CRC cis rs9894429 0.646 rs9902264 chr17:79613828 G/A cg09655341 chr17:79618100 PDE6G -0.35 -6.03 -0.32 4.46e-9 Eye color traits; CRC cis rs7178572 0.568 rs62008452 chr15:77591007 A/G cg22256960 chr15:77711686 NA -0.66 -9.58 -0.47 2.5e-19 Type 2 diabetes; CRC cis rs6500602 0.702 rs11645519 chr16:4538989 G/A cg14951292 chr16:4525986 HMOX2;NMRAL1 0.57 8.66 0.43 2.23e-16 Schizophrenia; CRC cis rs208520 0.526 rs1385219 chr6:66754476 C/T cg07460842 chr6:66804631 NA 1.11 20.77 0.75 8.49e-62 Exhaled nitric oxide output; CRC cis rs9399135 0.935 rs987690 chr6:135350379 A/G cg22676075 chr6:135203613 NA 0.4 6.26 0.33 1.19e-9 Red blood cell count; CRC cis rs3809863 0.602 rs11650072 chr17:45393665 A/G cg08085267 chr17:45401833 C17orf57 -0.77 -12.86 -0.58 6.13e-31 Glaucoma (primary open-angle); CRC cis rs3806843 1.000 rs13157397 chr5:140184442 G/A cg19875535 chr5:140030758 IK 0.61 9.83 0.48 3.56e-20 Depressive symptoms (multi-trait analysis); CRC cis rs734999 0.967 rs10797434 chr1:2511280 C/T cg18854424 chr1:2615690 NA 0.34 6.5 0.34 2.98e-10 Ulcerative colitis; CRC cis rs10751667 0.643 rs7396951 chr11:927355 G/A cg06064525 chr11:970664 AP2A2 -0.33 -6.65 -0.34 1.25e-10 Alzheimer's disease (late onset); CRC cis rs6964587 1.000 rs7811564 chr7:91663364 A/G cg17063962 chr7:91808500 NA 0.8 14.15 0.62 7.64e-36 Breast cancer; CRC cis rs7927592 0.913 rs11228268 chr11:68287447 A/T cg01657329 chr11:68192670 LRP5 -0.46 -6.53 -0.34 2.47e-10 Total body bone mineral density; CRC cis rs11030122 0.632 rs4910596 chr11:4084604 A/G cg18678763 chr11:4115507 RRM1 -0.55 -8.89 -0.44 4.13e-17 Mean platelet volume;Platelet distribution width; CRC cis rs72945132 0.882 rs7937984 chr11:70144254 C/T cg00319359 chr11:70116639 PPFIA1 0.62 6.89 0.36 2.82e-11 Coronary artery disease; CRC cis rs9291683 0.588 rs3756237 chr4:10013378 G/A cg00071950 chr4:10020882 SLC2A9 0.68 13.33 0.59 1.07e-32 Bone mineral density; CRC cis rs35264875 0.851 rs72930621 chr11:68866745 C/T cg15234197 chr11:68924956 NA 0.43 6.19 0.32 1.79e-9 Blond vs. brown hair color; CRC cis rs1348850 0.874 rs13013752 chr2:178456862 A/G cg02961200 chr2:178257176 LOC100130691;AGPS 0.47 6.74 0.35 7.16e-11 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs7772486 0.558 rs9497403 chr6:146054695 T/G cg13319975 chr6:146136371 FBXO30 0.63 9.16 0.45 5.61e-18 Lobe attachment (rater-scored or self-reported); CRC cis rs7412746 0.634 rs12096831 chr1:150864113 T/G cg17724175 chr1:150552817 MCL1 0.44 6.54 0.34 2.34e-10 Melanoma; CRC cis rs13191362 0.935 rs116735807 chr6:163010615 A/G cg23758597 chr6:163146217 PARK2 -0.56 -6.17 -0.32 2.03e-9 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs5769765 0.955 rs6520066 chr22:50294988 C/T cg02269571 chr22:50332266 NA -0.57 -8.03 -0.4 1.78e-14 Schizophrenia; CRC cis rs2032447 0.832 rs6922788 chr6:26052291 C/T cg27635394 chr6:26043820 HIST1H2BB 0.39 5.77 0.3 1.8e-8 Intelligence (multi-trait analysis); CRC cis rs9435341 1.000 rs1762484 chr1:107613923 A/C cg14828511 chr1:107599125 PRMT6 -0.54 -7.45 -0.38 8.11e-13 Facial morphology (factor 21, depth of nasal alae); CRC cis rs2120019 0.938 rs8033925 chr15:75311959 A/G cg11632617 chr15:75315747 PPCDC -0.57 -7.85 -0.4 5.77e-14 Blood trace element (Zn levels); CRC cis rs11112613 0.713 rs12321309 chr12:105943263 T/G cg03607813 chr12:105948248 NA 0.83 10.31 0.49 8.89e-22 Corrected insulin response;Corrected insulin response adjusted for insulin sensitivity index; CRC cis rs875971 1.000 rs10215948 chr7:65747786 G/A cg18912574 chr7:65842487 NCRNA00174 -0.37 -6.33 -0.33 7.93e-10 Aortic root size; CRC cis rs972578 0.875 rs4822250 chr22:43409058 C/A cg01576275 chr22:43409880 NA -0.48 -7.62 -0.39 2.78e-13 Mean platelet volume; CRC cis rs4481887 1.000 rs4916124 chr1:248466495 T/C cg00666640 chr1:248458726 OR2T12 0.52 9.22 0.45 3.57e-18 Common traits (Other); CRC cis rs977987 0.806 rs11643410 chr16:75428306 C/T cg03315344 chr16:75512273 CHST6 0.54 9.0 0.44 1.86e-17 Dupuytren's disease; CRC cis rs2836974 0.831 rs2836921 chr21:40516070 C/T cg06238570 chr21:40685208 BRWD1 0.7 9.24 0.45 3.12e-18 Cognitive function; CRC cis rs7552404 0.727 rs12093623 chr1:76256232 T/G cg03433033 chr1:76189801 ACADM 0.72 9.34 0.46 1.48e-18 Blood metabolite levels;Acylcarnitine levels; CRC cis rs1799949 0.965 rs799908 chr17:41278916 A/G cg19454999 chr17:41278357 BRCA1;NBR2 0.4 6.16 0.32 2.1e-9 Menopause (age at onset); CRC cis rs7917772 0.582 rs10786695 chr10:104368756 A/C cg11453585 chr10:104263688 ACTR1A;SUFU 0.82 15.13 0.64 1.23e-39 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC cis rs6540556 0.723 rs3766618 chr1:209895437 G/T cg05527609 chr1:210001259 C1orf107 -0.65 -6.21 -0.32 1.59e-9 Red blood cell count; CRC cis rs2576037 0.545 rs9948405 chr18:44494527 C/G cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.64 10.93 0.52 6.03e-24 Personality dimensions; CRC cis rs4862750 0.832 rs6419953 chr4:187900509 T/A cg11301795 chr4:187892539 NA -0.87 -20.32 -0.75 4.87e-60 Lobe attachment (rater-scored or self-reported); CRC cis rs873946 0.648 rs12769533 chr10:134548685 C/T cg26818010 chr10:134567672 INPP5A 0.65 8.61 0.43 2.97e-16 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg00531307 chr14:50998683 MAP4K5;ATL1 0.49 6.31 0.33 8.8e-10 Thyroid stimulating hormone; CRC cis rs4731207 0.596 rs4507709 chr7:124651533 C/T cg23710748 chr7:124431027 NA -0.39 -6.25 -0.33 1.24e-9 Cutaneous malignant melanoma; CRC cis rs8032158 1.000 rs7176225 chr15:56126857 G/A cg02198044 chr15:56286336 NEDD4 -0.39 -6.04 -0.32 4.06e-9 Keloid; CRC cis rs28386778 0.830 rs2854210 chr17:61946338 C/A cg06601766 chr17:61851465 DDX42;CCDC47 0.43 5.91 0.31 8.63e-9 Prudent dietary pattern; CRC cis rs936229 0.813 rs7085 chr15:75095483 T/C cg10253484 chr15:75165896 SCAMP2 -0.41 -5.97 -0.31 6.13e-9 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); CRC cis rs2742417 0.935 rs2742442 chr3:45748599 T/A cg04837898 chr3:45731254 SACM1L -0.36 -5.83 -0.31 1.34e-8 Response to anti-depressant treatment in major depressive disorder; CRC cis rs3750082 0.889 rs13230763 chr7:32912965 C/T cg05721444 chr7:32995514 FKBP9 0.51 7.87 0.4 5.33e-14 Glomerular filtration rate (creatinine); CRC cis rs2380220 0.808 rs2613547 chr6:95910311 C/T cg04719120 chr6:96025338 MANEA -0.53 -5.88 -0.31 9.93e-9 Behavioural disinhibition (generation interaction); CRC cis rs11971779 0.616 rs7784192 chr7:139039649 T/C cg07862535 chr7:139043722 LUC7L2 0.57 7.35 0.38 1.61e-12 Diisocyanate-induced asthma; CRC cis rs7258465 1.000 rs8109573 chr19:18617151 G/T cg06953865 chr19:18549723 ISYNA1 -0.38 -5.74 -0.3 2.18e-8 Breast cancer; CRC cis rs6448317 0.520 rs13116411 chr4:24928949 G/A cg21108841 chr4:24914750 CCDC149 -0.54 -7.88 -0.4 4.79e-14 Heschl's gyrus morphology; CRC cis rs2361718 0.501 rs11869566 chr17:78143248 T/C cg20811857 chr17:78079795 GAA -0.5 -7.13 -0.37 6.22e-12 Yeast infection; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg23780514 chr18:71959249 CYB5A 0.45 6.78 0.35 5.66e-11 Intelligence (multi-trait analysis); CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg03352657 chr17:26684557 POLDIP2;TMEM199 -0.39 -6.17 -0.32 1.98e-9 Myopia (pathological); CRC cis rs870825 0.929 rs55880126 chr4:185591237 T/G cg04058563 chr4:185651563 MLF1IP 0.7 7.14 0.37 5.83e-12 Blood protein levels; CRC cis rs11098499 0.754 rs1511017 chr4:120250805 G/A cg09307838 chr4:120376055 NA 0.61 9.59 0.47 2.22e-19 Corneal astigmatism; CRC cis rs2625529 0.652 rs2957745 chr15:72288077 T/C cg16672083 chr15:72433130 SENP8 0.47 7.13 0.37 6.32e-12 Red blood cell count; CRC cis rs2836974 0.865 rs34778912 chr21:40667037 T/G cg17971929 chr21:40555470 PSMG1 0.81 11.47 0.53 7.41e-26 Cognitive function; CRC cis rs2836974 0.533 rs418298 chr21:40536654 A/T cg22974920 chr21:40686053 BRWD1 0.41 5.75 0.3 2.01e-8 Cognitive function; CRC trans rs4332037 0.539 rs11762545 chr7:2060775 C/T cg11693508 chr17:37793320 STARD3 0.61 7.23 0.37 3.36e-12 Bipolar disorder; CRC cis rs9443645 0.901 rs2050662 chr6:79753073 G/C cg11833968 chr6:79620685 NA -0.36 -6.04 -0.32 4.07e-9 Intelligence (multi-trait analysis); CRC cis rs113835537 0.529 rs75003264 chr11:66256099 G/A cg22134325 chr11:66188745 NPAS4 0.28 5.8 0.3 1.55e-8 Airway imaging phenotypes; CRC cis rs7635838 0.750 rs7625680 chr3:11378069 G/A cg00170343 chr3:11313890 ATG7 0.46 7.08 0.36 8.84e-12 HDL cholesterol; CRC trans rs2727020 0.576 rs1917321 chr11:49377760 A/C cg21153622 chr11:89784906 NA -0.49 -8.28 -0.42 3.23e-15 Coronary artery disease; CRC trans rs7618501 0.573 rs7634917 chr3:50049299 T/G cg21659725 chr3:3221576 CRBN -0.61 -9.75 -0.47 6.99e-20 Intelligence (multi-trait analysis); CRC cis rs1105228 0.819 rs561112 chr6:165715891 T/C cg20535254 chr6:165714960 C6orf118 -0.28 -5.66 -0.3 3.22e-8 Number of pregnancies;Number of children; CRC cis rs172166 0.516 rs1225710 chr6:28100640 C/T cg15786705 chr6:28176104 NA -0.46 -6.74 -0.35 7.2e-11 Cardiac Troponin-T levels; CRC cis rs1534166 0.647 rs1464937 chr3:133536655 C/G cg01448562 chr3:133502909 NA 0.44 6.6 0.34 1.6e-10 Alcohol consumption (transferrin glycosylation); CRC cis rs425277 1.000 rs809912 chr1:2078385 C/T cg24578937 chr1:2090814 PRKCZ 0.66 11.79 0.54 5.46e-27 Height; CRC cis rs763121 0.819 rs5757126 chr22:38923675 T/C cg06022373 chr22:39101656 GTPBP1 0.71 10.35 0.5 6.24e-22 Menopause (age at onset); CRC cis rs72945132 0.882 rs67927691 chr11:70128786 C/A cg14191688 chr11:70257035 CTTN 0.4 5.62 0.3 4.07e-8 Coronary artery disease; CRC cis rs1005224 0.963 rs11623813 chr14:76138194 C/T cg04684003 chr14:76127793 TTLL5;C14orf1 -0.46 -6.49 -0.34 3.16e-10 Large artery stroke; CRC cis rs2739330 0.828 rs5760108 chr22:24252668 G/T cg24846343 chr22:24311635 DDTL 0.85 15.13 0.64 1.22e-39 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs1008375 1.000 rs10939743 chr4:17662731 G/A cg04450456 chr4:17643702 FAM184B 0.41 6.59 0.34 1.8e-10 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs909674 0.818 rs7364148 chr22:39842165 T/C cg05872129 chr22:39784769 NA -0.49 -8.58 -0.43 3.88e-16 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; CRC cis rs9660180 0.934 rs34849348 chr1:1762757 C/T cg05132306 chr1:1846340 CALML6 -0.48 -7.32 -0.37 1.9e-12 Body mass index; CRC cis rs4665809 0.938 rs4665822 chr2:26312555 C/G cg27170947 chr2:26402098 FAM59B -0.45 -6.03 -0.32 4.4e-9 Gut microbiome composition (summer); CRC cis rs6964587 1.000 rs9969198 chr7:91567492 G/T cg17063962 chr7:91808500 NA -0.77 -13.1 -0.59 7.96e-32 Breast cancer; CRC cis rs3749237 0.964 rs11717463 chr3:49808981 C/T cg24308560 chr3:49941425 MST1R -0.44 -6.09 -0.32 3.15e-9 Resting heart rate; CRC cis rs2739330 0.760 rs5760095 chr22:24247293 A/G cg09033563 chr22:24373618 LOC391322 -0.44 -6.02 -0.31 4.67e-9 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs28386778 0.897 rs10221279 chr17:61806138 A/G cg23090583 chr17:61904693 PSMC5;FTSJ3 1.03 19.28 0.73 5.63e-56 Prudent dietary pattern; CRC cis rs7208859 0.623 rs9914242 chr17:29216245 G/T cg13385521 chr17:29058706 SUZ12P 0.66 7.23 0.37 3.43e-12 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs9287719 0.699 rs4669602 chr2:10787967 C/T cg00105475 chr2:10696890 NA 0.45 7.11 0.36 7.28e-12 Prostate cancer; CRC cis rs6860806 0.631 rs7736284 chr5:131588151 T/C cg04518342 chr5:131593106 PDLIM4 0.46 8.52 0.43 5.95e-16 Breast cancer; CRC cis rs2204008 0.639 rs7311462 chr12:38278130 G/A cg26384229 chr12:38710491 ALG10B 0.69 9.22 0.45 3.69e-18 Bladder cancer; CRC cis rs2073499 1.000 rs6776145 chr3:50316119 C/T cg09545109 chr3:50388910 TUSC4;CYB561D2 -0.57 -6.28 -0.33 1.07e-9 Schizophrenia; CRC cis rs13256369 0.774 rs13260303 chr8:8587342 A/C cg17143192 chr8:8559678 CLDN23 0.48 6.25 0.33 1.26e-9 Obesity-related traits; CRC cis rs9467711 0.651 rs9467623 chr6:25860580 G/A cg16898833 chr6:26189333 HIST1H4D 0.84 6.86 0.35 3.32e-11 Autism spectrum disorder or schizophrenia; CRC cis rs6743226 0.901 rs4675968 chr2:242222492 T/C cg10021735 chr2:242295487 FARP2 0.46 6.55 0.34 2.22e-10 Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI in non-smokers; CRC cis rs60843830 1.000 rs9213 chr2:218386 G/A cg00108164 chr2:264199 ACP1;SH3YL1 0.63 9.88 0.48 2.47e-20 Spherical equivalent (joint analysis main effects and education interaction); CRC cis rs651907 0.557 rs11914318 chr3:101453858 C/T cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.59 7.94 0.4 3.21e-14 Colorectal cancer; CRC cis rs17711722 0.565 rs4275112 chr7:65198619 T/G cg18876405 chr7:65276391 NA -0.54 -9.05 -0.45 1.28e-17 Calcium levels; CRC cis rs7618915 0.547 rs4687638 chr3:52651966 A/C cg18404041 chr3:52824283 ITIH1 -0.44 -9.05 -0.45 1.26e-17 Bipolar disorder; CRC trans rs7647973 0.667 rs11721148 chr3:49646669 G/A cg21659725 chr3:3221576 CRBN -0.66 -7.14 -0.37 5.85e-12 Menarche (age at onset); CRC trans rs1005277 0.522 rs1208681 chr10:38092975 C/T cg27523141 chr10:43048294 ZNF37B 0.45 6.39 0.33 5.67e-10 Extrinsic epigenetic age acceleration; CRC cis rs9522267 0.535 rs9522305 chr13:112237550 A/G cg26182253 chr13:112236782 NA 0.31 6.23 0.32 1.4e-9 Hepatitis; CRC cis rs11039100 0.688 rs1993225 chr11:5841068 C/T cg03895540 chr11:5841482 OR52N2 -0.31 -5.66 -0.3 3.34e-8 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs6502050 0.805 rs4789740 chr17:80119202 T/C cg02741985 chr17:80059408 CCDC57 0.44 7.2 0.37 4.08e-12 Life satisfaction; CRC cis rs7591163 1.000 rs2396499 chr2:228724368 C/T cg00063174 chr2:228736253 WDR69 0.45 5.99 0.31 5.44e-9 Blood pressure; CRC cis rs17767392 0.813 rs8003478 chr14:72120363 C/G cg13720639 chr14:72061746 SIPA1L1 0.56 7.1 0.36 7.5e-12 Mitral valve prolapse; CRC cis rs3768617 0.510 rs10752904 chr1:183101038 A/G ch.1.3577855R chr1:183094577 LAMC1 0.89 15.86 0.66 1.84e-42 Fuchs's corneal dystrophy; CRC cis rs9462027 0.628 rs2814970 chr6:34713500 G/A cg07306190 chr6:34760872 UHRF1BP1 -0.35 -6.24 -0.33 1.36e-9 Systemic lupus erythematosus; CRC cis rs10504229 0.593 rs77607045 chr8:58010464 T/C cg20607798 chr8:58055168 NA 0.5 5.78 0.3 1.75e-8 Developmental language disorder (linguistic errors); CRC cis rs270601 0.739 rs3900945 chr5:131592870 T/C cg02033258 chr5:131593261 PDLIM4 0.46 8.73 0.43 1.28e-16 Acylcarnitine levels; CRC cis rs75920871 0.588 rs7112111 chr11:116980858 T/G cg01368799 chr11:117014884 PAFAH1B2 -0.46 -6.41 -0.33 4.95e-10 Subjective well-being; CRC cis rs10876993 0.890 rs7976852 chr12:58100551 T/G cg18357645 chr12:58087776 OS9 0.59 8.11 0.41 1.02e-14 Celiac disease or Rheumatoid arthritis; CRC cis rs11214589 0.651 rs11214594 chr11:113259332 G/A cg14159747 chr11:113255604 NA 0.62 12.64 0.57 4.07e-30 Neuroticism; CRC cis rs8060686 0.920 rs2292318 chr16:67985706 C/T cg19582491 chr16:67682965 RLTPR -0.58 -6.55 -0.34 2.26e-10 HDL cholesterol;Metabolic syndrome; CRC cis rs11031096 0.711 rs4910891 chr11:4153408 A/G cg18678763 chr11:4115507 RRM1 -0.51 -8.43 -0.42 1.09e-15 Mean corpuscular volume;Mean corpuscular hemoglobin; CRC cis rs17270561 0.541 rs2009610 chr6:25967068 C/T cg16482183 chr6:26056742 HIST1H1C 1.04 11.74 0.54 8.07e-27 Iron status biomarkers; CRC trans rs7267979 1.000 rs2500448 chr20:25404027 A/C cg17903999 chr18:56338584 MALT1 0.4 6.54 0.34 2.32e-10 Liver enzyme levels (alkaline phosphatase); CRC cis rs3820068 0.581 rs2861387 chr1:15951296 G/A cg27534772 chr1:16042836 PLEKHM2 0.54 10.65 0.51 5.81e-23 Systolic blood pressure; CRC cis rs2354432 0.607 rs6683243 chr1:146733422 A/T cg25205988 chr1:146714368 CHD1L -1.24 -9.92 -0.48 1.84e-20 Mitochondrial DNA levels; CRC cis rs9303401 0.659 rs11079358 chr17:56920949 G/T cg02118635 chr17:56770003 RAD51C;TEX14 0.78 9.94 0.48 1.59e-20 Cognitive test performance; CRC cis rs4718428 0.705 rs4718422 chr7:66359269 A/G cg18252515 chr7:66147081 NA -0.55 -7.65 -0.39 2.19e-13 Corneal structure; CRC cis rs7223966 0.921 rs6504186 chr17:61863932 G/A cg05941027 chr17:61774174 LIMD2 0.35 6.31 0.33 8.87e-10 Hip circumference adjusted for BMI;Body mass index; CRC cis rs2839186 0.770 rs2839171 chr21:47673247 C/T cg13126279 chr21:47581558 C21orf56 0.46 7.35 0.38 1.59e-12 Testicular germ cell tumor; CRC cis rs2624839 0.602 rs2526398 chr3:50187596 G/C cg05623727 chr3:50126028 RBM5 0.43 6.61 0.34 1.6e-10 Intelligence (multi-trait analysis); CRC cis rs4665809 1.000 rs10048683 chr2:26320519 C/T cg27170947 chr2:26402098 FAM59B -0.44 -5.89 -0.31 9.6e-9 Gut microbiome composition (summer); CRC cis rs8031584 0.918 rs35784593 chr15:31254588 G/A cg08109568 chr15:31115862 NA -0.54 -8.74 -0.43 1.22e-16 Huntington's disease progression; CRC cis rs9517320 0.967 rs6491430 chr13:99178276 G/A cg20487152 chr13:99095054 FARP1 0.36 5.67 0.3 3.09e-8 Longevity; CRC cis rs8014204 0.816 rs4903262 chr14:75340818 A/G cg03030879 chr14:75389066 RPS6KL1 -0.44 -7.11 -0.36 7.4e-12 Caffeine consumption; CRC cis rs58688157 0.705 rs12803132 chr11:586696 A/G cg16486109 chr11:613632 IRF7 0.73 11.8 0.55 4.83e-27 Systemic lupus erythematosus; CRC cis rs1865760 0.865 rs1436306 chr6:25948421 A/G cg16482183 chr6:26056742 HIST1H1C 0.52 7.35 0.38 1.59e-12 Height; CRC cis rs79387448 0.576 rs11902044 chr2:102972534 C/T cg09003973 chr2:102972529 NA 0.94 9.9 0.48 2.13e-20 Gut microbiota (bacterial taxa); CRC cis rs6831352 0.918 rs34936974 chr4:100052384 A/G cg13256891 chr4:100009986 ADH5 0.64 8.89 0.44 4.1e-17 Alcohol dependence; CRC trans rs1005277 0.522 rs1208681 chr10:38092975 C/T cg23533926 chr12:111358616 MYL2 -0.45 -6.61 -0.34 1.56e-10 Extrinsic epigenetic age acceleration; CRC cis rs11971779 0.680 rs28579232 chr7:139073116 C/G cg23387468 chr7:139079360 LUC7L2 0.41 7.04 0.36 1.14e-11 Diisocyanate-induced asthma; CRC cis rs6502050 0.777 rs6502058 chr17:80082500 A/C cg19223190 chr17:80058835 NA -0.39 -6.24 -0.33 1.31e-9 Life satisfaction; CRC cis rs4332037 0.510 rs11764040 chr7:1884830 G/C cg25834613 chr7:1915315 MAD1L1 -0.38 -6.42 -0.33 4.82e-10 Bipolar disorder; CRC cis rs7103648 0.897 rs35032070 chr11:47408592 G/A cg20307385 chr11:47447363 PSMC3 0.91 15.21 0.64 5.95e-40 Diastolic blood pressure;Systolic blood pressure; CRC cis rs4713118 0.540 rs469227 chr6:27970705 A/C cg20615401 chr6:28092323 ZSCAN16 0.44 5.77 0.3 1.82e-8 Parkinson's disease; CRC cis rs9837602 0.529 rs793495 chr3:99507934 A/G cg08350549 chr3:99591722 C3orf26;FILIP1L;MIR548G 0.38 5.77 0.3 1.87e-8 Breast cancer; CRC cis rs10191773 0.589 rs72831639 chr2:112949291 A/G cg23609528 chr2:113191194 RGPD5;RGPD8 0.68 5.68 0.3 2.9e-8 Yeast infection; CRC cis rs7618915 0.570 rs13068293 chr3:52672167 C/A cg10802521 chr3:52805072 NEK4 -0.58 -9.0 -0.44 1.8e-17 Bipolar disorder; CRC cis rs17592366 0.517 rs60007157 chr14:35312272 A/G cg09327582 chr14:35236912 BAZ1A 0.49 6.87 0.35 3.21e-11 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells; CRC cis rs7726839 0.540 rs72703078 chr5:594987 A/C cg16447950 chr5:562315 NA -0.73 -9.65 -0.47 1.41e-19 Obesity-related traits; CRC cis rs4243830 0.522 rs11122086 chr1:6601246 T/G cg15205204 chr1:6545172 PLEKHG5 0.39 5.75 0.3 1.99e-8 Body mass index; CRC cis rs2732480 0.577 rs2634691 chr12:48708259 G/T cg24011408 chr12:48396354 COL2A1 0.46 6.28 0.33 1.1e-9 Hemoglobin concentration;Red blood cell count;Hematocrit; CRC cis rs6456156 0.742 rs2022000 chr6:167529611 A/G cg07513332 chr6:167530253 CCR6 -0.48 -8.74 -0.43 1.21e-16 Primary biliary cholangitis; CRC trans rs916888 0.647 rs199523 chr17:44848517 C/A cg01341218 chr17:43662625 NA -0.56 -6.96 -0.36 1.82e-11 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs28386778 0.897 rs2584601 chr17:61940977 T/C cg06601766 chr17:61851465 DDX42;CCDC47 0.42 5.69 0.3 2.82e-8 Prudent dietary pattern; CRC cis rs10423674 0.526 rs11668545 chr19:18829529 C/T cg14292368 chr19:18793705 CRTC1 -0.38 -5.64 -0.3 3.71e-8 Menarche (age at onset); CRC cis rs4423214 0.559 rs7949129 chr11:71193135 G/C cg05163923 chr11:71159392 DHCR7 -0.61 -6.22 -0.32 1.51e-9 Vitamin D levels; CRC cis rs9303401 0.659 rs34913878 chr17:56897094 A/G cg02118635 chr17:56770003 RAD51C;TEX14 0.77 9.98 0.48 1.15e-20 Cognitive test performance; CRC cis rs7617773 0.817 rs6794644 chr3:48330037 T/C cg11946769 chr3:48343235 NME6 0.64 8.88 0.44 4.55e-17 Coronary artery disease; CRC cis rs6445967 0.933 rs6796069 chr3:58332508 C/T cg23715586 chr3:58305044 RPP14 0.36 5.78 0.3 1.74e-8 Platelet count; CRC cis rs9916302 0.861 rs632202 chr17:37453294 C/A cg07936489 chr17:37558343 FBXL20 0.76 11.16 0.52 9.43e-25 Glomerular filtration rate (creatinine); CRC cis rs1814175 0.529 rs10839396 chr11:49852406 G/T cg25886479 chr11:50257625 LOC441601 0.39 6.76 0.35 6.13e-11 Height; CRC cis rs7089973 0.604 rs2420066 chr10:116583897 A/G cg23260525 chr10:116636907 FAM160B1 0.35 8.07 0.41 1.34e-14 Bipolar disorder or attention deficit hyperactivity disorder; CRC cis rs2075371 1.000 rs2598288 chr7:133977304 A/T cg11752832 chr7:134001865 SLC35B4 0.48 7.44 0.38 8.72e-13 Mean platelet volume; CRC cis rs4253772 0.638 rs6007845 chr22:46718417 A/T cg03482458 chr22:46692211 CN5H6.4;GTSE1 -0.56 -7.15 -0.37 5.77e-12 LDL cholesterol;Cholesterol, total; CRC cis rs440932 1.000 rs365309 chr8:9026940 C/T cg06636001 chr8:8085503 FLJ10661 -0.61 -9.02 -0.45 1.59e-17 High light scatter reticulocyte percentage of red cells; CRC cis rs9733 0.596 rs7418501 chr1:150711896 A/T cg18016565 chr1:150552671 MCL1 0.43 6.14 0.32 2.37e-9 Tonsillectomy; CRC cis rs11212617 1.000 rs7108522 chr11:108281004 A/G cg14761454 chr11:108092087 ATM;NPAT 0.45 6.95 0.36 1.97e-11 Response to metformin in type 2 diabetes (glycemic); CRC cis rs11148252 0.683 rs9536006 chr13:52887707 T/G cg00495681 chr13:53174319 NA 0.6 9.1 0.45 8.68e-18 Lewy body disease; CRC trans rs13046373 0.905 rs4816372 chr21:32077414 A/T cg06900573 chr10:5978347 FBXO18 -0.41 -6.73 -0.35 7.66e-11 HDL cholesterol; CRC cis rs4268898 0.560 rs2384007 chr2:24514841 A/G cg06627628 chr2:24431161 ITSN2 -0.8 -10.79 -0.51 1.88e-23 Asthma; CRC cis rs4665809 1.000 rs2384322 chr2:26291146 C/G cg22920501 chr2:26401640 FAM59B -0.56 -7.28 -0.37 2.46e-12 Gut microbiome composition (summer); CRC cis rs2032447 0.839 rs6901039 chr6:26000885 A/C cg27635394 chr6:26043820 HIST1H2BB 0.39 5.75 0.3 2e-8 Intelligence (multi-trait analysis); CRC cis rs4665809 1.000 rs12469163 chr2:26283587 T/C cg25036284 chr2:26402008 FAM59B -0.46 -5.97 -0.31 6.25e-9 Gut microbiome composition (summer); CRC cis rs7617773 0.784 rs11715799 chr3:48255220 A/G cg11946769 chr3:48343235 NME6 0.73 9.78 0.47 5.46e-20 Coronary artery disease; CRC cis rs10256972 0.568 rs1133043 chr7:1133305 C/G cg03923535 chr7:1197113 ZFAND2A 0.62 8.93 0.44 3.01e-17 Longevity;Endometriosis; CRC cis rs7173389 1.000 rs7173389 chr15:73663903 A/T cg01796676 chr15:73680284 NA 0.5 6.69 0.35 9.74e-11 Resting heart rate; CRC cis rs208520 0.690 rs1100981 chr6:66852052 T/C cg07460842 chr6:66804631 NA -1.06 -14.8 -0.63 2.51e-38 Exhaled nitric oxide output; CRC trans rs35110281 0.837 rs7279968 chr21:45077398 C/G cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.42 6.89 0.36 2.9100000000000002e-11 Mean corpuscular volume; CRC cis rs853679 0.517 rs9368555 chr6:28108967 T/C cg21251018 chr6:28226885 NKAPL 0.48 6.17 0.32 2.02e-9 Depression; CRC cis rs10540 0.908 rs35608427 chr11:498976 T/C cg15790184 chr11:494944 RNH1 0.59 6.1 0.32 2.93e-9 Body mass index; CRC cis rs1448094 0.791 rs61929394 chr12:86331541 C/A cg18827107 chr12:86230957 RASSF9 -0.42 -6.64 -0.34 1.32e-10 Major depressive disorder; CRC cis rs8058578 1.000 rs8048448 chr16:30692208 T/C cg02466173 chr16:30829666 NA -0.76 -11.94 -0.55 1.56e-27 Multiple myeloma; CRC cis rs7945705 0.967 rs1569408 chr11:8909732 G/A cg12365402 chr11:9010492 NRIP3 0.48 7.75 0.39 1.13e-13 Hemoglobin concentration; CRC cis rs9322193 0.926 rs9383546 chr6:150143879 T/A cg05861140 chr6:150128134 PCMT1 -0.42 -6.74 -0.35 7e-11 Lung cancer; CRC cis rs9649213 0.593 rs62478177 chr7:97964611 G/A cg00277769 chr7:97922759 BAIAP2L1 -0.6 -10.45 -0.5 2.89e-22 Prostate cancer (SNP x SNP interaction); CRC cis rs1707322 1.000 rs785484 chr1:46574015 T/C cg06784218 chr1:46089804 CCDC17 -0.6 -10.19 -0.49 2.28e-21 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs1552172 0.845 rs17354594 chr1:145632500 A/G cg11743829 chr1:145714124 CD160 -0.42 -6.35 -0.33 7.05e-10 Breast cancer; CRC cis rs6502050 0.805 rs7225560 chr17:80160884 C/G cg13198984 chr17:80129470 CCDC57 0.48 8.5 0.42 6.51e-16 Life satisfaction; CRC cis rs8114671 0.662 rs6058146 chr20:33540529 A/G cg07148914 chr20:33460835 GGT7 0.39 6.29 0.33 9.86e-10 Height; CRC cis rs56307353 0.753 rs34318825 chr19:1961342 T/C cg24355006 chr19:1969744 CSNK1G2 0.5 8.15 0.41 7.62e-15 Coronary artery disease; CRC cis rs4363385 0.818 rs10888524 chr1:153000125 A/G cg25856811 chr1:152973957 SPRR3 -0.25 -6.8 -0.35 5.09e-11 Inflammatory skin disease; CRC cis rs7932354 0.528 rs11039105 chr11:47157677 A/T cg03339077 chr11:47165057 C11orf49 -0.45 -6.19 -0.32 1.75e-9 Bone mineral density (hip);Bone mineral density; CRC cis rs951366 0.789 rs823110 chr1:205701078 G/C cg11965913 chr1:205819406 PM20D1 0.83 13.36 0.59 8.29e-33 Menarche (age at onset); CRC trans rs1005277 0.579 rs2983343 chr10:38383332 A/G cg17830980 chr10:43048298 ZNF37B -0.6 -9.93 -0.48 1.67e-20 Extrinsic epigenetic age acceleration; CRC cis rs6951245 1.000 rs76129108 chr7:1089159 G/A cg24642844 chr7:1081250 C7orf50 -0.79 -9.35 -0.46 1.4e-18 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC trans rs783540 0.900 rs12916980 chr15:83306447 C/G cg18393722 chr15:85113863 UBE2QP1 -0.41 -7.25 -0.37 3.05e-12 Schizophrenia; CRC cis rs10991814 0.920 rs16907323 chr9:94025459 A/G cg14446406 chr9:93919335 NA 0.5 5.68 0.3 3.01e-8 Neutrophil percentage of granulocytes; CRC cis rs67311347 1.000 rs73080138 chr3:40516417 A/G cg09455208 chr3:40491958 NA 0.45 9.19 0.45 4.49e-18 Renal cell carcinoma; CRC cis rs4253772 0.550 rs6007761 chr22:46670394 C/T cg09491104 chr22:46646882 C22orf40 0.42 6.42 0.33 4.87e-10 LDL cholesterol;Cholesterol, total; CRC cis rs7647973 0.626 rs4855846 chr3:49683526 G/A cg03060546 chr3:49711283 APEH 0.68 8.2 0.41 5.37e-15 Menarche (age at onset); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg03793131 chr1:43833547 ELOVL1 0.44 6.51 0.34 2.82e-10 Liver disease severity in Alagille syndrome; CRC cis rs45430 1.000 rs443099 chr21:42743327 G/T cg22778903 chr21:42741698 MX2 0.42 7.01 0.36 1.36e-11 Melanoma; CRC cis rs1005277 0.579 rs176838 chr10:38371899 A/T cg25517755 chr10:38738941 LOC399744 0.41 5.99 0.31 5.61e-9 Extrinsic epigenetic age acceleration; CRC cis rs12477438 0.700 rs10190421 chr2:99670711 C/T cg26064155 chr2:99771622 LIPT1;TSGA10 -0.79 -11.26 -0.53 4.44e-25 Chronic sinus infection; CRC trans rs66887589 0.967 rs13104219 chr4:120438174 G/T cg25214090 chr10:38739885 LOC399744 0.42 6.47 0.34 3.65e-10 Diastolic blood pressure; CRC trans rs61931739 0.500 rs34107854 chr12:34482333 C/A cg26384229 chr12:38710491 ALG10B 0.67 8.78 0.44 9.23e-17 Morning vs. evening chronotype; CRC cis rs736408 0.677 rs2286798 chr3:52821177 G/T cg05573699 chr3:52720067 GNL3;PBRM1 0.41 5.84 0.31 1.24e-8 Bipolar disorder; CRC trans rs629535 0.814 rs488231 chr8:70064993 T/C cg21567404 chr3:27674614 NA 0.92 15.29 0.64 2.9e-40 Dupuytren's disease; CRC cis rs5769707 0.935 rs1109320 chr22:49989106 G/A cg20744362 chr22:50050164 C22orf34 0.3 6.01 0.31 5.03e-9 Monocyte count;Monocyte percentage of white cells; CRC cis rs7927592 0.731 rs11228275 chr11:68303980 G/A cg01657329 chr11:68192670 LRP5 0.58 9.66 0.47 1.3e-19 Total body bone mineral density; CRC cis rs2180341 0.781 rs7760652 chr6:127572096 A/G cg27446573 chr6:127587934 RNF146 0.76 11.44 0.53 9.62e-26 Breast cancer; CRC cis rs13082711 0.554 rs73055750 chr3:27401505 C/G cg02860705 chr3:27208620 NA 0.85 10.98 0.52 4.2e-24 Systolic blood pressure;Diastolic blood pressure;Blood pressure; CRC cis rs75920871 0.528 rs7128772 chr11:116889411 T/A cg20608306 chr11:116969690 SIK3 -0.33 -6.4 -0.33 5.32e-10 Subjective well-being; CRC cis rs8180040 1.000 rs11714294 chr3:47339723 G/A cg27129171 chr3:47204927 SETD2 -0.67 -10.38 -0.5 5.17e-22 Colorectal cancer; CRC trans rs7267979 0.844 rs6083845 chr20:25388090 G/C cg17903999 chr18:56338584 MALT1 0.41 6.64 0.34 1.27e-10 Liver enzyme levels (alkaline phosphatase); CRC cis rs938554 0.779 rs4639073 chr4:9973781 T/C cg00071950 chr4:10020882 SLC2A9 -0.45 -6.02 -0.32 4.54e-9 Blood metabolite levels; CRC cis rs9858213 1 rs9858213 chr3:49731861 G/T cg00383909 chr3:49044727 WDR6 0.46 5.62 0.3 4.12e-8 Educational attainment; CRC cis rs514406 0.825 rs1242328 chr1:53396869 A/G cg27535305 chr1:53392650 SCP2 -0.4 -7.17 -0.37 4.9e-12 Monocyte count; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg19947233 chr4:90032727 TIGD2 0.37 6.42 0.33 4.71e-10 Liver disease severity in Alagille syndrome; CRC cis rs72615157 0.634 rs7789890 chr7:99800559 G/T cg00814883 chr7:100076585 TSC22D4 -0.51 -6.11 -0.32 2.82e-9 Lung function (FEV1/FVC); CRC trans rs6951245 0.554 rs78999139 chr7:1138525 G/A cg13565492 chr6:43139072 SRF -0.83 -10.59 -0.5 9.91e-23 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs9814567 0.896 rs6799110 chr3:134206749 T/C cg06541857 chr3:134203789 ANAPC13;CEP63 -0.41 -6.21 -0.32 1.63e-9 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs6545883 0.929 rs10190332 chr2:61619267 T/G cg15711740 chr2:61764176 XPO1 0.43 5.81 0.31 1.47e-8 Tuberculosis; CRC cis rs1799949 1.000 rs8176083 chr17:41275151 G/C cg01879757 chr17:41196368 BRCA1 -0.41 -6.18 -0.32 1.9e-9 Menopause (age at onset); CRC cis rs7659604 1.000 rs7689722 chr4:122665955 T/C cg19748678 chr4:122722346 EXOSC9 0.56 8.9 0.44 3.69e-17 Type 2 diabetes; CRC cis rs3750082 0.632 rs7811630 chr7:32960718 C/A cg05721444 chr7:32995514 FKBP9 0.5 6.37 0.33 6.34e-10 Glomerular filtration rate (creatinine); CRC cis rs9291683 0.704 rs11726271 chr4:10098192 G/A cg11266682 chr4:10021025 SLC2A9 -0.41 -8.11 -0.41 1.01e-14 Bone mineral density; CRC cis rs61008539 0.893 rs4721502 chr7:862186 A/G cg15782153 chr7:917662 C7orf20 0.48 7.89 0.4 4.48e-14 Perceived unattractiveness to mosquitoes; CRC cis rs7584330 0.737 rs7568588 chr2:238364342 G/T cg14458575 chr2:238380390 NA 0.63 11.61 0.54 2.34e-26 Prostate cancer; CRC cis rs10504229 0.906 rs112793785 chr8:58190537 T/C cg05313129 chr8:58192883 C8orf71 -0.47 -6.96 -0.36 1.82e-11 Developmental language disorder (linguistic errors); CRC cis rs6546550 0.901 rs10205487 chr2:70151471 C/T cg02498382 chr2:70120550 SNRNP27 0.54 9.07 0.45 1.14e-17 Prevalent atrial fibrillation; CRC cis rs4690686 0.538 rs11730551 chr4:177259182 A/G cg17059388 chr4:177262070 NA 0.38 5.71 0.3 2.52e-8 Essential tremor; CRC cis rs12997796 0.556 rs34353387 chr2:86974834 A/C cg25203885 chr2:87302643 LOC285074 -0.58 -6.02 -0.31 4.67e-9 Schizophrenia; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg17241999 chr3:171758173 FNDC3B 0.4 6.56 0.34 2.13e-10 Liver disease severity in Alagille syndrome; CRC cis rs9733 0.818 rs4970926 chr1:150673684 T/C cg18016565 chr1:150552671 MCL1 -0.43 -6.3 -0.33 9.32e-10 Tonsillectomy; CRC cis rs853679 0.760 rs2299029 chr6:28198831 G/A cg12273811 chr6:28175739 NA 0.55 6.09 0.32 3.19e-9 Depression; CRC cis rs10504229 0.906 rs58559296 chr8:58171714 T/C cg22535103 chr8:58192502 C8orf71 -0.82 -12.27 -0.56 9.63e-29 Developmental language disorder (linguistic errors); CRC cis rs9443645 0.901 rs971994 chr6:79559602 G/C cg11833968 chr6:79620685 NA -0.36 -6.39 -0.33 5.61e-10 Intelligence (multi-trait analysis); CRC cis rs6502050 0.835 rs8067875 chr17:80092778 C/T cg22110888 chr17:80059540 CCDC57 0.39 6.22 0.32 1.51e-9 Life satisfaction; CRC cis rs3902035 0.964 rs17349133 chr6:118998633 C/T cg01339444 chr6:118972232 C6orf204 0.44 5.61 0.3 4.4e-8 QT interval; CRC cis rs561341 0.943 rs508566 chr17:30289861 G/C cg12193833 chr17:30244370 NA -0.75 -8.73 -0.43 1.27e-16 Hip circumference adjusted for BMI; CRC trans rs7267979 1.000 rs2257809 chr20:25266476 C/T cg17903999 chr18:56338584 MALT1 -0.42 -7.0 -0.36 1.41e-11 Liver enzyme levels (alkaline phosphatase); CRC cis rs11758351 0.660 rs113208674 chr6:26210465 C/G cg10723962 chr6:26240782 HIST1H4F -0.39 -6.26 -0.33 1.23e-9 Gout;Renal underexcretion gout; CRC cis rs3749237 0.595 rs11130192 chr3:49467206 C/G cg03060546 chr3:49711283 APEH 0.69 11.87 0.55 2.67e-27 Resting heart rate; CRC trans rs1814175 0.650 rs6486000 chr11:49659090 T/A cg11707556 chr5:10655725 ANKRD33B -0.49 -9.03 -0.45 1.53e-17 Height; CRC trans rs9388451 0.591 rs1268792 chr6:126042124 G/A cg05039488 chr6:79577232 IRAK1BP1 0.46 6.86 0.35 3.4e-11 Brugada syndrome; CRC cis rs4285028 0.851 rs1986368 chr3:121710969 A/T cg11130432 chr3:121712080 ILDR1 -0.5 -6.5 -0.34 2.97e-10 Multiple sclerosis; CRC cis rs1008375 1.000 rs7659718 chr4:17638020 A/C cg16339924 chr4:17578868 LAP3 0.54 7.05 0.36 1.03e-11 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs6500395 1.000 rs6500395 chr16:48621402 T/C cg04672837 chr16:48644449 N4BP1 0.45 6.75 0.35 6.7e-11 Response to tocilizumab in rheumatoid arthritis; CRC cis rs11764590 0.694 rs10235664 chr7:2086814 T/C cg14004847 chr7:1930337 MAD1L1 -0.45 -6.2 -0.32 1.73e-9 Neuroticism; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg24677674 chr10:113943468 GPAM 0.51 6.58 0.34 1.81e-10 Thyroid stimulating hormone; CRC cis rs873946 0.564 rs2803992 chr10:134550882 T/C cg18305652 chr10:134549665 INPP5A 0.46 6.66 0.34 1.13e-10 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CRC cis rs929843 1 rs929843 chr16:70045748 A/C cg09409435 chr16:70099608 PDXDC2 0.82 9.29 0.46 2.24e-18 Menarche (age at onset); CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg21703068 chr21:35015322 ITSN1;CRYZL1 0.46 6.49 0.34 3.1e-10 Anxiety disorder; CRC cis rs13096760 1 rs13096760 chr3:49476806 T/C cg02487422 chr3:49467188 NICN1 0.43 6.87 0.35 3.18e-11 Intelligence (multi-trait analysis); CRC cis rs4727027 0.933 rs2158633 chr7:148832652 C/T cg12479418 chr7:148823350 ZNF425;ZNF398 0.45 6.04 0.32 4.19e-9 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC trans rs951252 0.504 rs11734405 chr4:146081096 C/T cg13896783 chr2:159313876 CCDC148;PKP4 0.53 7.17 0.37 5.11e-12 Hip circumference; CRC cis rs3785574 0.927 rs2854160 chr17:61977248 C/T cg22520471 chr17:61851767 DDX42;CCDC47 0.46 6.25 0.33 1.3e-9 Height; CRC trans rs7395662 0.611 rs7478698 chr11:48549139 T/C cg00717180 chr2:96193071 NA -0.37 -6.1 -0.32 2.94e-9 HDL cholesterol; CRC cis rs1555322 0.530 rs2425042 chr20:33865895 G/A cg07134254 chr20:33865797 NA 0.45 5.69 0.3 2.84e-8 Attention deficit hyperactivity disorder; CRC cis rs919433 0.929 rs4850788 chr2:198182940 G/A cg10820045 chr2:198174542 NA -0.58 -11.78 -0.54 5.97e-27 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC cis rs6088580 0.505 rs6142219 chr20:33256345 G/A cg08999081 chr20:33150536 PIGU -0.37 -5.61 -0.3 4.4e-8 Glomerular filtration rate (creatinine); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg12743425 chr17:29877216 NA 0.47 6.71 0.35 8.53e-11 Response to antipsychotic treatment; CRC cis rs35146811 0.844 rs13232115 chr7:99670932 T/C cg00553149 chr7:99775558 STAG3;GPC2 0.23 5.61 0.3 4.32e-8 Coronary artery disease; CRC cis rs73206853 0.686 rs73206895 chr12:110879968 A/G cg12870014 chr12:110450643 ANKRD13A 0.83 9.88 0.48 2.46e-20 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC cis rs72634258 0.520 rs12078018 chr1:7857309 G/A cg26816564 chr1:7831052 VAMP3 0.85 9.89 0.48 2.35e-20 Inflammatory bowel disease; CRC cis rs1799949 0.827 rs74252763 chr17:41402020 C/T cg05368731 chr17:41323189 NBR1 0.67 9.76 0.47 6.24e-20 Menopause (age at onset); CRC cis rs6502050 0.723 rs11650635 chr17:80083816 T/C cg09264619 chr17:80180166 NA 0.36 6.08 0.32 3.4e-9 Life satisfaction; CRC cis rs2396545 0.680 rs35467761 chr11:571568 A/G cg03909863 chr11:638404 DRD4 -0.45 -5.73 -0.3 2.26e-8 Systemic lupus erythematosus and Systemic sclerosis; CRC cis rs4975709 0.610 rs4975704 chr5:1859807 C/A cg12288994 chr5:1860383 NA 0.38 6.62 0.34 1.43e-10 Cardiovascular disease risk factors; CRC cis rs524281 0.731 rs11227433 chr11:66004693 G/A cg14036092 chr11:66035641 RAB1B -0.56 -6.35 -0.33 7.22e-10 Electroencephalogram traits; CRC cis rs4434138 0.594 rs7653028 chr3:52763000 A/T cg08222913 chr3:52553049 STAB1 -0.33 -6.08 -0.32 3.4e-9 Intelligence (multi-trait analysis); CRC cis rs8078723 0.866 rs11078934 chr17:38189793 C/T cg17467752 chr17:38218738 THRA 0.74 12.02 0.55 8.05e-28 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); CRC cis rs11098499 0.954 rs28572238 chr4:120316686 T/G cg24375607 chr4:120327624 NA 0.5 7.74 0.39 1.22e-13 Corneal astigmatism; CRC cis rs7692995 1.000 rs6813340 chr4:17922866 A/G cg08925142 chr4:18023851 LCORL -0.53 -5.77 -0.3 1.83e-8 Height; CRC trans rs1814175 0.935 rs7950947 chr11:49668369 C/T cg11707556 chr5:10655725 ANKRD33B -0.43 -7.96 -0.4 2.78e-14 Height; CRC cis rs1790761 0.501 rs4930210 chr11:67404726 G/T cg24690094 chr11:67383802 NA -0.35 -6.1 -0.32 2.92e-9 Mean corpuscular volume; CRC cis rs9783347 0.754 rs4757637 chr11:18307575 G/T cg15585147 chr11:18324498 HPS5 0.43 6.36 0.33 6.74e-10 Pancreatic cancer; CRC cis rs2032447 0.933 rs1540275 chr6:26036476 T/C cg12588279 chr6:26043732 HIST1H2BB 0.47 6.83 0.35 4e-11 Intelligence (multi-trait analysis); CRC cis rs9527 0.590 rs2148198 chr10:104915310 A/G cg04362960 chr10:104952993 NT5C2 -0.62 -8.46 -0.42 9.19e-16 Arsenic metabolism; CRC cis rs868036 0.522 rs3784711 chr15:68072527 C/T cg05925327 chr15:68127851 NA 0.29 5.9 0.31 9.15e-9 Restless legs syndrome; CRC cis rs1153858 1.000 rs4627277 chr15:45652768 C/A cg21132104 chr15:45694354 SPATA5L1 0.6 8.9 0.44 3.91e-17 Homoarginine levels; CRC cis rs12188164 0.620 rs1043356 chr5:480948 C/T cg21972741 chr5:435613 AHRR -0.48 -5.61 -0.3 4.35e-8 Cystic fibrosis severity; CRC cis rs17270561 0.609 rs1318016 chr6:25764704 A/T cg17691542 chr6:26056736 HIST1H1C 0.64 8.14 0.41 8.02e-15 Iron status biomarkers; CRC cis rs4243830 0.850 rs7540913 chr1:6581877 C/T cg22792644 chr1:6614718 TAS1R1;NOL9 -0.73 -9.33 -0.46 1.61e-18 Body mass index; CRC cis rs6582630 0.555 rs11182148 chr12:38464883 A/C cg26384229 chr12:38710491 ALG10B 0.69 9.79 0.47 5.13e-20 Drug-induced liver injury (flucloxacillin); CRC trans rs4332037 0.722 rs7788921 chr7:1915282 C/A cg11693508 chr17:37793320 STARD3 0.58 7.25 0.37 3.07e-12 Bipolar disorder; CRC cis rs12900463 0.813 rs187316 chr15:85405995 T/C cg17507749 chr15:85114479 UBE2QP1 0.43 5.65 0.3 3.45e-8 Adverse response to chemotherapy (neutropenia/leucopenia) (gemcitabine); CRC cis rs4727027 0.704 rs12704071 chr7:148904795 C/T cg23583168 chr7:148888333 NA -0.88 -15.84 -0.66 2.12e-42 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC cis rs514406 0.505 rs6703127 chr1:53180565 C/T cg24675658 chr1:53192096 ZYG11B -0.66 -9.75 -0.47 6.86e-20 Monocyte count; CRC cis rs57221529 0.766 rs28563961 chr5:554498 C/G cg16447950 chr5:562315 NA -0.83 -11.04 -0.52 2.6e-24 Lung disease severity in cystic fibrosis; CRC cis rs7772486 0.654 rs4896829 chr6:145953675 T/A cg05347473 chr6:146136440 FBXO30 0.42 6.28 0.33 1.05e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs932287 1.000 rs932287 chr11:9044767 A/G cg21881798 chr11:8931708 C11orf17;ST5 -0.46 -7.0 -0.36 1.4e-11 Colonoscopy-negative controls vs population controls; CRC trans rs7615952 0.512 rs34651730 chr3:125358640 T/C cg00769240 chr8:12517080 NA -0.74 -10.23 -0.49 1.64e-21 Blood pressure (smoking interaction); CRC cis rs801193 1.000 rs3778909 chr7:66255646 G/C cg11764359 chr7:65958608 NA 0.53 8.15 0.41 7.6e-15 Aortic root size; CRC cis rs67311347 1.000 rs10510708 chr3:40404770 A/G cg09455208 chr3:40491958 NA 0.42 8.63 0.43 2.73e-16 Renal cell carcinoma; CRC cis rs6860806 0.507 rs274572 chr5:131710917 T/G cg02033258 chr5:131593261 PDLIM4 -0.38 -6.46 -0.34 3.76e-10 Breast cancer; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg00974835 chr14:74960278 NPC2;ISCA2 -0.45 -6.95 -0.36 2.01e-11 Myopia (pathological); CRC cis rs9902453 0.791 rs62068629 chr17:28187596 G/C cg26525008 chr17:28256777 EFCAB5;SSH2 0.57 8.69 0.43 1.78e-16 Coffee consumption (cups per day); CRC cis rs769267 0.895 rs1858999 chr19:19497669 C/G cg03709012 chr19:19516395 GATAD2A -0.74 -11.66 -0.54 1.53e-26 Tonsillectomy; CRC cis rs6570726 0.516 rs10484700 chr6:145728933 C/T cg23711669 chr6:146136114 FBXO30 0.44 7.1 0.36 7.6e-12 Lobe attachment (rater-scored or self-reported); CRC cis rs6495122 0.501 rs12148488 chr15:75382542 G/T cg18612461 chr15:75251733 NA -0.38 -5.9 -0.31 8.98e-9 Caffeine consumption;Diastolic blood pressure;Coffee consumption; CRC cis rs6964587 1.000 rs35317449 chr7:91637010 G/A cg17063962 chr7:91808500 NA 0.81 14.49 0.62 3.74e-37 Breast cancer; CRC cis rs4713118 0.513 rs149942 chr6:28001610 T/C cg06470822 chr6:28175283 NA 0.79 12.11 0.56 3.51e-28 Parkinson's disease; CRC cis rs71403859 0.667 rs12924650 chr16:71705908 C/T cg08717414 chr16:71523259 ZNF19 -0.97 -8.88 -0.44 4.45e-17 Post bronchodilator FEV1; CRC cis rs2153535 0.542 rs9505465 chr6:8510846 C/T cg21535247 chr6:8435926 SLC35B3 0.47 7.15 0.37 5.52e-12 Motion sickness; CRC cis rs2014572 0.510 rs8111661 chr19:57752326 C/G cg24459738 chr19:57751996 ZNF805 0.52 7.85 0.4 5.82e-14 Hyperactive-impulsive symptoms; CRC cis rs9900062 0.519 rs2676293 chr17:62710461 T/C cg02097616 chr17:62675921 NA 0.53 7.69 0.39 1.69e-13 QT interval; CRC cis rs11716531 0.512 rs7612312 chr3:27230230 C/A cg02860705 chr3:27208620 NA 0.48 7.27 0.37 2.68e-12 Diastolic blood pressure; CRC cis rs4660306 0.961 rs2152077 chr1:45986670 G/T cg03123370 chr1:45965343 CCDC163P;MMACHC -0.53 -7.79 -0.39 9.08e-14 Homocysteine levels; CRC cis rs2952156 0.876 rs903504 chr17:37829570 C/G cg11212589 chr17:38028394 ZPBP2 0.34 5.93 0.31 7.48e-9 Asthma; CRC cis rs12230513 0.732 rs7310335 chr12:55884439 C/T cg19537932 chr12:55886519 OR6C68 -0.71 -9.09 -0.45 9.57e-18 Contrast sensitivity; CRC cis rs763014 0.593 rs28455838 chr16:681966 T/C cg10096052 chr16:615709 NHLRC4 -0.34 -5.71 -0.3 2.55e-8 Height; CRC cis rs12477438 0.798 rs13409996 chr2:99575497 C/T cg26064155 chr2:99771622 LIPT1;TSGA10 -0.75 -10.56 -0.5 1.23e-22 Chronic sinus infection; CRC cis rs561341 0.739 rs1978116 chr17:30220978 A/C cg00745463 chr17:30367425 LRRC37B -0.6 -7.87 -0.4 5.24e-14 Hip circumference adjusted for BMI; CRC cis rs763014 0.932 rs34498660 chr16:666149 A/G cg03804128 chr16:635623 NA 0.31 7.37 0.38 1.39e-12 Height; CRC cis rs6570726 0.967 rs450973 chr6:145863065 C/A cg23711669 chr6:146136114 FBXO30 0.65 11.02 0.52 3e-24 Lobe attachment (rater-scored or self-reported); CRC cis rs1218582 0.772 rs4845694 chr1:154911651 C/G cg16680214 chr1:154839983 KCNN3 -0.45 -8.9 -0.44 3.87e-17 Prostate cancer; CRC cis rs7131987 0.683 rs7954278 chr12:29459290 G/A cg09582351 chr12:29534625 ERGIC2 -0.34 -7.38 -0.38 1.34e-12 QT interval; CRC cis rs7224685 0.501 rs11649992 chr17:4026823 A/C cg09695851 chr17:3907499 NA -0.78 -13.71 -0.6 3.91e-34 Type 2 diabetes; CRC cis rs595982 0.559 rs4802516 chr19:49366170 T/C cg15549821 chr19:49342101 PLEKHA4 -0.56 -6.61 -0.34 1.59e-10 Red cell distribution width; CRC cis rs7552404 1.000 rs7518038 chr1:76154430 G/A cg22875332 chr1:76189707 ACADM 0.68 9.29 0.46 2.24e-18 Blood metabolite levels;Acylcarnitine levels; CRC cis rs6582630 0.555 rs6582503 chr12:38557886 A/C cg13010199 chr12:38710504 ALG10B 0.46 5.8 0.3 1.56e-8 Drug-induced liver injury (flucloxacillin); CRC cis rs826838 0.935 rs7301104 chr12:39182821 C/T cg26384229 chr12:38710491 ALG10B 0.68 9.32 0.46 1.69e-18 Heart rate; CRC cis rs1552244 0.810 rs35711405 chr3:10116939 C/T cg13047869 chr3:10149882 C3orf24 0.57 7.8 0.4 8.27e-14 Alzheimer's disease; CRC cis rs600806 0.850 rs10858091 chr1:109935578 T/C cg23032129 chr1:109941072 SORT1 -0.28 -6.06 -0.32 3.68e-9 Intelligence (multi-trait analysis); CRC cis rs769267 0.895 rs2315279 chr19:19479936 C/A cg17414380 chr19:19431394 KIAA0892;SF4 -0.41 -5.64 -0.3 3.69e-8 Tonsillectomy; CRC cis rs5417 0.788 rs2654185 chr17:7183362 G/T cg14660024 chr17:7154518 C17orf81;DULLARD -0.47 -8.0 -0.4 2.16e-14 Diastolic blood pressure; CRC cis rs57466243 1 rs57466243 chr17:27059666 T/A cg12682573 chr17:27188876 MIR451;MIR144 -0.37 -5.76 -0.3 1.96e-8 Reticulocyte count; CRC cis rs875971 0.862 rs778707 chr7:65857027 G/A cg18252515 chr7:66147081 NA -0.42 -5.99 -0.31 5.64e-9 Aortic root size; CRC cis rs4713118 0.955 rs9468201 chr6:27687035 C/T cg19041857 chr6:27730383 NA -0.43 -5.99 -0.31 5.63e-9 Parkinson's disease; CRC cis rs12926788 0.542 rs6497759 chr16:24801737 G/A cg06028605 chr16:24865363 SLC5A11 0.59 9.58 0.47 2.51e-19 Ejection fraction in Tripanosoma cruzi seropositivity; CRC cis rs9858542 1.000 rs34762726 chr3:49689210 G/A cg00383909 chr3:49044727 WDR6 0.47 5.9 0.31 9.07e-9 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs2760061 0.626 rs672907 chr1:228120345 G/A cg02753203 chr1:228287806 NA -0.66 -10.07 -0.49 5.83e-21 Diastolic blood pressure; CRC trans rs58688157 0.705 rs12419694 chr11:598033 C/T cg19188899 chr13:112838565 NA -0.38 -6.02 -0.31 4.65e-9 Systemic lupus erythematosus; CRC cis rs9549367 0.636 rs486407 chr13:113833499 G/A cg24300038 chr13:113819356 PROZ 0.51 6.69 0.35 9.53e-11 Platelet distribution width; CRC cis rs891088 0.622 rs10426094 chr19:7205240 C/T cg09779027 chr19:7224513 INSR -0.58 -7.17 -0.37 4.92e-12 Hip circumference adjusted for BMI;Height; CRC cis rs9733 0.596 rs7549795 chr1:150656873 G/A cg18016565 chr1:150552671 MCL1 0.47 6.77 0.35 5.86e-11 Tonsillectomy; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg20299236 chr22:32870557 FBXO7 0.49 6.41 0.33 5.09e-10 Thyroid stimulating hormone; CRC cis rs6717918 0.620 rs76788222 chr2:233152479 T/G ch.2.233013039R chr2:233304795 NA 0.58 6.58 0.34 1.88e-10 Height; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg12171159 chr11:72504902 STARD10 -0.38 -6.11 -0.32 2.76e-9 Myopia (pathological); CRC trans rs6550704 0.687 rs9865314 chr3:22634337 A/G cg02970425 chr20:48552805 RNF114 -0.44 -6.84 -0.35 3.84e-11 Daytime sleep phenotypes; CRC cis rs9372498 0.536 rs72954806 chr6:118899965 C/G cg22561889 chr6:118971681 C6orf204 0.47 5.9 0.31 9.09e-9 Diastolic blood pressure; CRC cis rs5753618 0.583 rs2273249 chr22:31836486 T/C cg07713946 chr22:31675144 LIMK2 0.37 5.67 0.3 3.1e-8 Colorectal cancer; CRC cis rs1065852 0.526 rs2413663 chr22:42402399 T/A cg22189786 chr22:42395067 WBP2NL 0.44 6.44 0.33 4.35e-10 Response to serotonin reuptake inhibitors in major depressive disorder (plasma drug and metabolite levels); CRC cis rs2153535 0.541 rs9379207 chr6:8458186 C/T cg07606381 chr6:8435919 SLC35B3 0.69 11.15 0.52 1.04e-24 Motion sickness; CRC cis rs2732480 0.577 rs2634684 chr12:48730875 C/T cg04545296 chr12:48745243 ZNF641 -0.38 -6.46 -0.34 3.67e-10 Hemoglobin concentration;Red blood cell count;Hematocrit; CRC cis rs2836974 0.644 rs11088472 chr21:40699376 A/C cg17971929 chr21:40555470 PSMG1 -0.65 -9.79 -0.47 5.14e-20 Cognitive function; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg23325948 chr5:169011174 CCDC99 0.48 6.96 0.36 1.82e-11 Response to antipsychotic treatment; CRC cis rs734999 0.566 rs10797435 chr1:2534801 G/C cg18854424 chr1:2615690 NA 0.4 7.74 0.39 1.22e-13 Ulcerative colitis; CRC cis rs11864453 1.000 rs2278027 chr16:72051369 A/G cg01557791 chr16:72042693 DHODH -0.51 -7.18 -0.37 4.57e-12 Fibrinogen levels; CRC cis rs2952156 0.652 rs11869286 chr17:37813856 C/G cg20243544 chr17:37824526 PNMT 0.53 8.53 0.43 5.41e-16 Asthma; CRC trans rs4957048 0.891 rs11960196 chr5:568857 C/A cg25482853 chr8:67687455 SGK3 0.98 12.17 0.56 2.19e-28 Ulcerative colitis; CRC cis rs7412746 0.563 rs3768013 chr1:150815411 G/A cg17724175 chr1:150552817 MCL1 0.45 6.77 0.35 6.07e-11 Melanoma; CRC cis rs1150668 0.830 rs2531831 chr6:28388765 C/G cg03623178 chr6:28175578 NA 0.48 6.95 0.36 1.94e-11 Pubertal anthropometrics; CRC cis rs6988636 0.710 rs17315999 chr8:124153763 A/G cg27053337 chr8:124217698 FAM83A 0.4 5.65 0.3 3.42e-8 Urinary uromodulin levels; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg05672380 chr19:36505394 ALKBH6 0.45 6.54 0.34 2.36e-10 Intelligence (multi-trait analysis); CRC cis rs847577 0.722 rs1013886 chr7:97709861 A/G cg24562669 chr7:97807699 LMTK2 -0.76 -16.61 -0.68 2.03e-45 Breast cancer; CRC cis rs12887734 0.524 rs4906363 chr14:104210239 G/A cg08213375 chr14:104286397 PPP1R13B 0.49 8.14 0.41 8e-15 Schizophrenia;Autism spectrum disorder or schizophrenia; CRC cis rs1799949 1.000 rs2298862 chr17:41176688 T/C cg19454999 chr17:41278357 BRCA1;NBR2 0.53 8.09 0.41 1.2e-14 Menopause (age at onset); CRC cis rs66573146 1.000 rs67067921 chr4:6984341 A/T cg00086871 chr4:6988644 TBC1D14 1.02 7.68 0.39 1.81e-13 Granulocyte percentage of myeloid white cells; CRC cis rs892961 0.899 rs66749226 chr17:75412826 G/A cg05865280 chr17:75406074 SEPT9 0.61 13.71 0.6 3.82e-34 Airflow obstruction; CRC trans rs7267979 1.000 rs6107033 chr20:25363591 A/G cg17903999 chr18:56338584 MALT1 0.4 6.59 0.34 1.78e-10 Liver enzyme levels (alkaline phosphatase); CRC cis rs2153535 0.580 rs1832100 chr6:8446956 G/A cg07606381 chr6:8435919 SLC35B3 0.68 10.84 0.51 1.3e-23 Motion sickness; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg01109508 chr10:135187068 ECHS1 0.39 6.35 0.33 7.15e-10 Liver disease severity in Alagille syndrome; CRC trans rs4263408 0.934 rs9683743 chr4:39703194 A/C cg27043427 chr17:65362820 PSMD12 -0.44 -6.36 -0.33 6.67e-10 Plasma amyloid beta peptide concentrations (ABx-40); CRC cis rs629535 0.862 rs598548 chr8:70032438 C/T cg26132723 chr8:70041827 NA 0.35 5.72 0.3 2.41e-8 Dupuytren's disease; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg11234017 chr17:42767172 CCDC43 0.56 7.46 0.38 7.76e-13 Thyroid stimulating hormone; CRC cis rs1862618 0.853 rs252915 chr5:56121754 C/T cg22800045 chr5:56110881 MAP3K1 -0.5 -5.65 -0.3 3.45e-8 Initial pursuit acceleration; CRC cis rs3096299 0.667 rs2965947 chr16:89518670 T/C cg00750074 chr16:89608354 SPG7 -0.5 -7.64 -0.39 2.39e-13 Multiple myeloma (IgH translocation); CRC cis rs35146811 0.700 rs2950520 chr7:99827148 T/C cg00553149 chr7:99775558 STAG3;GPC2 -0.25 -5.75 -0.3 1.99e-8 Coronary artery disease; CRC cis rs644148 0.836 rs2571111 chr19:45000581 C/A cg15540054 chr19:45004280 ZNF180 -0.59 -8.37 -0.42 1.73e-15 Personality dimensions; CRC cis rs10256972 0.616 rs4585652 chr7:1145396 A/G cg16145915 chr7:1198662 ZFAND2A -0.4 -7.57 -0.39 3.7e-13 Longevity;Endometriosis; CRC trans rs747334 0.713 rs7078592 chr10:92727797 A/T cg19856520 chr1:39696676 MACF1 -0.33 -5.96 -0.31 6.4e-9 Fibroblast growth factor basic levels; CRC cis rs1552244 0.554 rs3846167 chr3:9996426 T/C cg02579736 chr3:10068473 FANCD2;CIDECP 0.64 9.07 0.45 1.07e-17 Alzheimer's disease; CRC trans rs9929218 0.954 rs57688464 chr16:68826109 G/C cg04657470 chr2:198365150 HSPE1;HSPD1 -0.8 -11.51 -0.54 5.47e-26 Colorectal cancer; CRC cis rs6582630 0.519 rs12819814 chr12:38332568 G/C cg13010199 chr12:38710504 ALG10B 0.46 6.21 0.32 1.64e-9 Drug-induced liver injury (flucloxacillin); CRC cis rs6570726 0.791 rs12205752 chr6:145896118 A/G cg23711669 chr6:146136114 FBXO30 0.69 11.52 0.54 4.94e-26 Lobe attachment (rater-scored or self-reported); CRC cis rs3091242 0.933 rs28633797 chr1:25741629 C/A cg23205692 chr1:25664452 TMEM50A 0.42 5.93 0.31 7.74e-9 Erythrocyte sedimentation rate; CRC cis rs9527 0.545 rs7095304 chr10:104954795 G/A cg04362960 chr10:104952993 NT5C2 0.61 8.51 0.42 6.45e-16 Arsenic metabolism; CRC cis rs681343 0.746 rs633372 chr19:49209226 G/A cg21064579 chr19:49206444 FUT2 0.5 8.74 0.43 1.25e-16 Lung adenocarcinoma;Primary sclerosing cholangitis;Childhood ear infection; CRC cis rs7618915 0.547 rs11709448 chr3:52647449 T/C cg15147215 chr3:52552868 STAB1 -0.62 -10.27 -0.49 1.2e-21 Bipolar disorder; CRC cis rs7617773 0.963 rs12495221 chr3:48179178 C/T cg11946769 chr3:48343235 NME6 -0.45 -6.25 -0.33 1.29e-9 Coronary artery disease; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg09968765 chr19:3985171 EEF2 0.48 6.68 0.35 1.03e-10 Response to antipsychotic treatment; CRC trans rs11722228 0.521 rs12501336 chr4:10137351 G/A cg26043149 chr18:55253948 FECH 1.15 19.38 0.73 2.36e-56 Gout;Urate levels;Serum uric acid levels; CRC cis rs6951245 0.678 rs28600085 chr7:1169636 C/T cg21664854 chr7:1097933 C7orf50;GPR146 0.69 8.27 0.41 3.4e-15 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs10760158 0.832 rs10760169 chr9:124057682 C/T cg14417974 chr9:124058376 GSN -0.34 -5.75 -0.3 2.04e-8 Pulse pressure; CRC cis rs7772486 0.686 rs1292334 chr6:145968288 A/G cg23711669 chr6:146136114 FBXO30 0.72 12.3 0.56 7.5e-29 Lobe attachment (rater-scored or self-reported); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg23068124 chr14:58711505 PSMA3 0.45 6.33 0.33 7.91e-10 Response to antipsychotic treatment; CRC cis rs6570726 0.764 rs4263604 chr6:145916697 A/G cg13319975 chr6:146136371 FBXO30 -0.42 -5.97 -0.31 6.18e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs34034915 1 rs34034915 chr6:27720703 T/TG cg15786705 chr6:28176104 NA 0.49 7.03 0.36 1.18e-11 Hepatitis A; CRC cis rs1799949 0.929 rs12937015 chr17:41307473 A/C cg05368731 chr17:41323189 NBR1 0.69 10.5 0.5 1.97e-22 Menopause (age at onset); CRC cis rs2463822 0.592 rs72919486 chr11:62043501 G/C cg06239285 chr11:62104954 ASRGL1 -0.86 -8.51 -0.42 6.38e-16 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs6968419 0.755 rs4730720 chr7:115895235 C/T cg02561103 chr7:115862891 TES 0.44 6.61 0.34 1.6e-10 Intraocular pressure; CRC cis rs559928 0.597 rs11600667 chr11:63976183 C/T cg19465662 chr11:63993652 NUDT22;TRPT1 0.71 6.6 0.34 1.64e-10 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; CRC cis rs77633900 0.614 rs2629021 chr15:76974083 C/T cg21673338 chr15:77095150 SCAPER -0.75 -7.82 -0.4 7.28e-14 Non-glioblastoma glioma;Glioma; CRC cis rs1799949 1.000 rs4534897 chr17:41431808 A/G cg23758822 chr17:41437982 NA 0.79 13.42 0.59 4.56e-33 Menopause (age at onset); CRC trans rs9467711 1.000 rs6908156 chr6:26322861 C/T cg15845792 chr6:28175446 NA 0.67 6.52 0.34 2.71e-10 Autism spectrum disorder or schizophrenia; CRC cis rs3741151 0.686 rs7118982 chr11:73110668 T/C cg17517138 chr11:73019481 ARHGEF17 0.57 6.02 0.32 4.62e-9 GIP levels in response to oral glucose tolerance test (120 minutes); CRC cis rs12142240 0.698 rs72886907 chr1:46814265 C/T cg00530320 chr1:46809349 NSUN4 0.58 7.81 0.4 7.54e-14 Menopause (age at onset); CRC cis rs10242455 0.702 rs73403247 chr7:99088730 G/A cg18809830 chr7:99032528 PTCD1 -1.18 -8.59 -0.43 3.66e-16 Blood metabolite levels; CRC cis rs9443645 0.901 rs9361466 chr6:79618352 T/C cg11833968 chr6:79620685 NA -0.36 -6.33 -0.33 8.07e-10 Intelligence (multi-trait analysis); CRC cis rs1448094 0.556 rs61930626 chr12:86167445 A/G cg25456477 chr12:86230367 RASSF9 0.4 6.71 0.35 8.75e-11 Major depressive disorder; CRC cis rs7208859 0.673 rs11650305 chr17:29229361 A/C cg13385521 chr17:29058706 SUZ12P 0.65 7.62 0.39 2.68e-13 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs12291225 0.877 rs2303974 chr11:14264979 G/T cg19336497 chr11:14380999 RRAS2 -0.39 -6.39 -0.33 5.65e-10 Sense of smell; CRC cis rs2239547 0.657 rs2276817 chr3:52860936 C/T cg11645453 chr3:52864694 ITIH4 0.62 11.22 0.53 5.75e-25 Schizophrenia; CRC cis rs2075371 0.829 rs1993058 chr7:133930361 G/A cg02659138 chr7:134003124 SLC35B4 0.38 6.23 0.32 1.47e-9 Mean platelet volume; CRC trans rs3806843 0.900 rs2531341 chr5:140130894 C/T cg06840491 chr10:48416966 GDF2 -0.35 -6.04 -0.32 4.16e-9 Depressive symptoms (multi-trait analysis); CRC cis rs11098499 0.754 rs9999724 chr4:120239944 C/T cg24375607 chr4:120327624 NA 0.48 7.75 0.39 1.16e-13 Corneal astigmatism; CRC cis rs17095355 1.000 rs11194941 chr10:111744810 A/G cg00817464 chr10:111662876 XPNPEP1 -0.63 -8.57 -0.43 3.99e-16 Biliary atresia; CRC cis rs6502050 0.835 rs12945993 chr17:80129485 T/C cg13198984 chr17:80129470 CCDC57 0.46 8.07 0.41 1.35e-14 Life satisfaction; CRC cis rs4665809 1.000 rs6546736 chr2:26293878 C/T cg26119090 chr2:26468346 HADHA;HADHB 0.6 7.71 0.39 1.54e-13 Gut microbiome composition (summer); CRC cis rs769267 0.930 rs4808964 chr19:19603692 A/C cg01262667 chr19:19385393 TM6SF2 -0.36 -5.95 -0.31 6.7e-9 Tonsillectomy; CRC cis rs28374715 0.532 rs11854632 chr15:41682094 A/G cg18705301 chr15:41695430 NDUFAF1 1.1 19.92 0.74 1.84e-58 Ulcerative colitis; CRC cis rs3768617 0.510 rs6691755 chr1:183099821 G/A ch.1.3577855R chr1:183094577 LAMC1 0.89 15.86 0.66 1.84e-42 Fuchs's corneal dystrophy; CRC cis rs3862260 0.509 rs10802124 chr1:120164252 G/A cg11530693 chr1:120165357 ZNF697 0.61 9.64 0.47 1.54e-19 Systemic lupus erythematosus; CRC cis rs3126085 0.696 rs41266112 chr1:152185762 C/G cg09127314 chr1:152161683 NA 0.5 6.31 0.33 9.03e-10 Atopic dermatitis; CRC cis rs3924048 0.574 rs11121931 chr1:12617009 G/A cg00291366 chr1:12616550 NA 0.6 10.78 0.51 2.11e-23 Optic cup area; CRC cis rs7575873 1 rs7575873 chr2:23962647 A/G cg08917208 chr2:24149416 ATAD2B 1.03 9.71 0.47 9.22e-20 Birth weight; CRC cis rs72772090 0.539 rs72773917 chr5:96111302 A/T cg17330273 chr5:96107758 CAST;ERAP1 -0.7 -6.31 -0.33 8.86e-10 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg11122148 chr13:45150705 TSC22D1 0.37 6.7 0.35 9.23e-11 Liver disease severity in Alagille syndrome; CRC cis rs4363385 0.818 rs9659389 chr1:152989844 T/C cg25856811 chr1:152973957 SPRR3 -0.25 -7.1 -0.36 7.84e-12 Inflammatory skin disease; CRC trans rs7824557 0.527 rs2572447 chr8:11239510 G/A cg06636001 chr8:8085503 FLJ10661 -0.44 -6.47 -0.34 3.6e-10 Retinal vascular caliber; CRC trans rs2243480 1.000 rs1723269 chr7:65472786 C/G cg10756647 chr7:56101905 PSPH 0.74 7.99 0.4 2.29e-14 Diabetic kidney disease; CRC cis rs270601 0.770 rs932019 chr5:131599370 T/C cg09877947 chr5:131593287 PDLIM4 0.54 10.07 0.49 5.53e-21 Acylcarnitine levels; CRC cis rs7945705 0.840 rs10840136 chr11:8885024 C/T cg00186954 chr11:8933980 ST5;C11orf17 -0.49 -8.29 -0.42 2.99e-15 Hemoglobin concentration; CRC cis rs10504229 0.728 rs55812114 chr8:58157453 C/T cg08219700 chr8:58056026 NA 0.46 5.72 0.3 2.37e-8 Developmental language disorder (linguistic errors); CRC cis rs11148252 0.595 rs9526974 chr13:53251040 C/G cg12458913 chr13:53173898 NA 0.75 13.66 0.6 5.78e-34 Lewy body disease; CRC cis rs12024301 0.557 rs12045516 chr1:183625631 G/T cg11505048 chr1:183622726 RGL1;APOBEC4 0.81 7.0 0.36 1.42e-11 Peripheral arterial disease (traffic-related air pollution interaction); CRC trans rs951252 0.504 rs11734405 chr4:146081096 C/T cg23819836 chr6:15663134 DTNBP1 0.46 6.08 0.32 3.26e-9 Hip circumference; CRC cis rs875971 0.830 rs6976714 chr7:65891461 G/A cg11764359 chr7:65958608 NA 0.6 9.01 0.44 1.71e-17 Aortic root size; CRC cis rs10504229 0.679 rs11786328 chr8:58039269 A/G cg20607798 chr8:58055168 NA 0.5 5.74 0.3 2.2e-8 Developmental language disorder (linguistic errors); CRC cis rs7605827 0.930 rs11692377 chr2:15659848 C/T cg19274914 chr2:15703543 NA 0.39 5.86 0.31 1.13e-8 Educational attainment (years of education); CRC cis rs875971 1.000 rs6460295 chr7:65882728 T/C cg00343986 chr7:65444356 GUSB 0.43 6.3 0.33 9.66e-10 Aortic root size; CRC cis rs9322193 0.962 rs17673294 chr6:150134993 G/A cg13206674 chr6:150067644 NUP43 0.59 8.32 0.42 2.34e-15 Lung cancer; CRC trans rs10983614 1.000 rs7867776 chr9:120072627 A/G cg02711976 chr1:36023590 NCDN;KIAA0319L 0.47 6.16 0.32 2.07e-9 Survival in pancreatic cancer; CRC cis rs7617480 0.610 rs10865954 chr3:49211989 T/C cg07636037 chr3:49044803 WDR6 0.74 11.25 0.53 4.76e-25 Subjective well-being (multi-trait analysis);Menarche (age at onset); CRC cis rs17125944 0.505 rs74642116 chr14:53213507 A/G cg00686598 chr14:53173677 PSMC6 1.18 10.89 0.51 8.81e-24 Alzheimer's disease (late onset); CRC cis rs4588572 0.606 rs4290994 chr5:77742253 C/T cg11446398 chr5:77624930 NA 0.41 5.98 0.31 5.91e-9 Triglycerides; CRC cis rs4731207 0.596 rs6980448 chr7:124569418 A/G cg23710748 chr7:124431027 NA -0.39 -6.14 -0.32 2.42e-9 Cutaneous malignant melanoma; CRC cis rs2239547 0.522 rs2581801 chr3:52972907 G/T cg10802521 chr3:52805072 NEK4 0.45 6.2 0.32 1.7e-9 Schizophrenia; CRC cis rs3091242 0.933 rs9438905 chr1:25764177 A/G cg27572855 chr1:25598939 RHD 0.35 6.05 0.32 3.88e-9 Erythrocyte sedimentation rate; CRC cis rs16856186 0.520 rs73082334 chr1:205800125 T/C cg07157834 chr1:205819609 PM20D1 -0.57 -5.65 -0.3 3.44e-8 Pulmonary function decline; CRC cis rs9435341 0.965 rs55924375 chr1:107566690 C/A cg15468180 chr1:107600409 PRMT6 0.38 5.72 0.3 2.45e-8 Facial morphology (factor 21, depth of nasal alae); CRC trans rs7618501 0.574 rs6765484 chr3:50041313 C/T cg21659725 chr3:3221576 CRBN -0.54 -8.51 -0.42 6.45e-16 Intelligence (multi-trait analysis); CRC cis rs703842 1.000 rs8181644 chr12:58173466 A/G cg00677455 chr12:58241039 CTDSP2 0.63 8.52 0.43 5.84e-16 Multiple sclerosis; CRC trans rs6601327 0.606 rs4841204 chr8:9583407 G/A cg06636001 chr8:8085503 FLJ10661 -0.5 -7.33 -0.37 1.76e-12 Multiple myeloma (hyperdiploidy); CRC cis rs4076764 0.958 rs11590567 chr1:163396438 A/G cg06092702 chr1:163392909 NA -0.61 -9.72 -0.47 8.51e-20 Motion sickness; CRC cis rs7618501 0.633 rs9814664 chr3:50078541 C/T cg05623727 chr3:50126028 RBM5 -0.43 -7.27 -0.37 2.72e-12 Intelligence (multi-trait analysis); CRC cis rs7618915 0.501 rs13060048 chr3:52598608 G/A cg18404041 chr3:52824283 ITIH1 -0.41 -8.69 -0.43 1.71e-16 Bipolar disorder; CRC cis rs9914988 0.943 rs4794839 chr17:27131393 G/A cg12682573 chr17:27188876 MIR451;MIR144 0.58 7.99 0.4 2.37e-14 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs3091242 0.933 rs10903130 chr1:25769221 A/T cg27572855 chr1:25598939 RHD 0.35 6.14 0.32 2.35e-9 Erythrocyte sedimentation rate; CRC cis rs7399018 1.000 rs7399018 chr12:51610365 C/T cg25754956 chr12:51612065 POU6F1 -0.72 -9.46 -0.46 6.22e-19 Cisplatin-induced ototoxicity; CRC cis rs951366 0.622 rs11580015 chr1:205676088 G/C cg14893161 chr1:205819251 PM20D1 0.82 12.53 0.57 1.02e-29 Menarche (age at onset); CRC cis rs1046896 0.519 rs9900369 chr17:80829807 G/A cg03160526 chr17:80928410 B3GNTL1 0.57 7.72 0.39 1.37e-13 Glycated hemoglobin levels; CRC cis rs59918340 0.728 rs6987335 chr8:142235358 T/G cg23750338 chr8:142222470 SLC45A4 -0.6 -10.52 -0.5 1.72e-22 Immature fraction of reticulocytes; CRC cis rs9322193 0.924 rs9322189 chr6:149909933 T/C cg00933542 chr6:150070202 PCMT1 0.33 6.74 0.35 7.09e-11 Lung cancer; CRC trans rs10504229 1.000 rs67344620 chr8:58187537 C/A cg04077850 chr5:125800366 GRAMD3 0.37 6.27 0.33 1.15e-9 Developmental language disorder (linguistic errors); CRC cis rs4819052 0.851 rs7276591 chr21:46680156 C/T cg02159808 chr21:46707872 POFUT2;LOC642852 0.51 6.74 0.35 7.12e-11 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs870825 0.616 rs9631782 chr4:185626379 A/G cg04058563 chr4:185651563 MLF1IP 0.72 9.38 0.46 1.12e-18 Blood protein levels; CRC cis rs9894429 0.690 rs11869779 chr17:79570067 C/T cg21984481 chr17:79567631 NPLOC4 0.58 11.05 0.52 2.45e-24 Eye color traits; CRC cis rs7208859 0.623 rs8075163 chr17:29106310 A/G cg13385521 chr17:29058706 SUZ12P 0.73 8.4 0.42 1.39e-15 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs6867032 1.000 rs6867032 chr5:2015103 G/T cg26168224 chr5:2018326 NA -0.98 -18.85 -0.72 2.78e-54 Gut microbiome composition (winter); CRC cis rs6545883 0.868 rs2427885 chr2:61816777 A/G cg15711740 chr2:61764176 XPO1 -0.53 -7.17 -0.37 5e-12 Tuberculosis; CRC cis rs7274811 0.711 rs184110 chr20:31981432 G/A cg07470512 chr20:32255052 NECAB3;C20orf134 0.45 6.21 0.32 1.64e-9 Height; CRC cis rs11098499 0.754 rs4107728 chr4:120253910 G/A cg09307838 chr4:120376055 NA 0.62 9.62 0.47 1.88e-19 Corneal astigmatism; CRC cis rs7772486 0.686 rs9373473 chr6:146082282 A/G cg13319975 chr6:146136371 FBXO30 -0.39 -5.84 -0.31 1.27e-8 Lobe attachment (rater-scored or self-reported); CRC trans rs1814175 0.645 rs1963215 chr11:49931486 G/A cg11707556 chr5:10655725 ANKRD33B -0.52 -9.95 -0.48 1.49e-20 Height; CRC cis rs738322 0.600 rs5995542 chr22:38558141 C/T cg03162506 chr22:38580953 NA 0.28 6.0 0.31 5.31e-9 Cutaneous nevi; CRC cis rs9818758 0.607 rs9862483 chr3:49195441 G/A cg00383909 chr3:49044727 WDR6 1.12 10.64 0.51 6.59e-23 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; CRC cis rs514406 0.758 rs532242 chr1:53308665 C/G cg25767906 chr1:53392781 SCP2 -0.47 -7.43 -0.38 9.49e-13 Monocyte count; CRC cis rs7635838 0.927 rs13082150 chr3:11437813 T/C cg00170343 chr3:11313890 ATG7 0.41 6.28 0.33 1.08e-9 HDL cholesterol; CRC cis rs3771570 1.000 rs62193207 chr2:242318501 G/C cg21155796 chr2:242212141 HDLBP 0.65 7.01 0.36 1.34e-11 Prostate cancer; CRC cis rs13082711 0.522 rs7651661 chr3:27362773 G/C cg02860705 chr3:27208620 NA 0.49 7.22 0.37 3.61e-12 Systolic blood pressure;Diastolic blood pressure;Blood pressure; CRC cis rs11212617 0.967 rs11212616 chr11:108281322 T/A cg14761454 chr11:108092087 ATM;NPAT 0.43 6.43 0.33 4.4e-10 Response to metformin in type 2 diabetes (glycemic); CRC cis rs5757676 0.858 rs6001585 chr22:39812986 G/T cg11247378 chr22:39784982 NA -0.38 -5.87 -0.31 1.08e-8 IgG glycosylation; CRC cis rs4478858 0.709 rs7514640 chr1:31752316 G/A cg00250761 chr1:31883323 NA -0.44 -8.59 -0.43 3.52e-16 Alcohol dependence; CRC cis rs17253792 0.822 rs112308750 chr14:56080073 G/A cg24579896 chr14:56047964 C14orf33;KTN1 0.71 5.69 0.3 2.81e-8 Putamen volume; CRC cis rs1552244 0.882 rs112621205 chr3:10017916 G/A cg08888203 chr3:10149979 C3orf24 0.62 8.23 0.41 4.29e-15 Alzheimer's disease; CRC cis rs10504229 0.683 rs61364624 chr8:58134339 T/A cg22535103 chr8:58192502 C8orf71 -0.7 -9.34 -0.46 1.47e-18 Developmental language disorder (linguistic errors); CRC cis rs909002 0.962 rs1474181 chr1:32136610 C/G cg13919466 chr1:32135498 COL16A1 -0.39 -7.4 -0.38 1.11e-12 Intelligence (multi-trait analysis); CRC cis rs7917772 0.636 rs2482499 chr10:104516246 G/A cg11453585 chr10:104263688 ACTR1A;SUFU 0.68 10.01 0.48 8.88e-21 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC cis rs60871478 0.636 rs56393680 chr7:885696 A/G cg05535760 chr7:792225 HEATR2 -0.93 -10.49 -0.5 2.11e-22 Cerebrospinal P-tau181p levels; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg21694044 chr22:41215540 SLC25A17 0.4 6.75 0.35 6.84e-11 Liver disease severity in Alagille syndrome; CRC cis rs7254114 0.618 rs7250652 chr19:11302606 A/G cg02815516 chr19:11306319 KANK2 -0.34 -6.62 -0.34 1.48e-10 Immature fraction of reticulocytes; CRC trans rs1814175 0.615 rs12417290 chr11:49876951 G/A cg15704280 chr7:45808275 SEPT13 -0.94 -16.65 -0.68 1.36e-45 Height; CRC cis rs7666738 0.830 rs1115616 chr4:99006603 A/C cg05340658 chr4:99064831 C4orf37 0.61 9.49 0.46 4.96e-19 Colonoscopy-negative controls vs population controls; CRC cis rs2549003 1.000 rs7701588 chr5:131819970 T/C cg00255919 chr5:131827918 IRF1 0.59 11.92 0.55 1.77e-27 Asthma (sex interaction); CRC cis rs6502050 0.799 rs8069827 chr17:80089168 C/T cg25804541 chr17:80189381 SLC16A3 -0.3 -5.84 -0.31 1.24e-8 Life satisfaction; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg26051060 chr21:43916302 RSPH1 0.43 6.09 0.32 3.21e-9 Response to antipsychotic treatment; CRC cis rs6504622 1.000 rs1047779 chr17:45019243 T/G cg16759221 chr17:45003025 GOSR2 0.45 7.1 0.36 7.68e-12 Orofacial clefts; CRC cis rs172166 0.652 rs476167 chr6:28065888 T/C cg21251018 chr6:28226885 NKAPL 0.47 7.26 0.37 2.83e-12 Cardiac Troponin-T levels; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg01038479 chr17:35767307 TADA2A;ACACA 0.45 6.16 0.32 2.17e-9 Response to antipsychotic treatment; CRC cis rs2836974 0.565 rs34304022 chr21:40579619 G/A cg17971929 chr21:40555470 PSMG1 0.59 6.16 0.32 2.16e-9 Cognitive function; CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg14875093 chr19:38398164 WDR87;SIPA1L3 -0.59 -7.09 -0.36 8.05e-12 Diisocyanate-induced asthma; CRC cis rs2276314 0.512 rs1789515 chr18:33635893 G/A cg05985134 chr18:33552581 C18orf21 -0.37 -5.83 -0.31 1.3e-8 Endometriosis;Drug-induced torsades de pointes; CRC cis rs9487051 0.752 rs9372209 chr6:109601684 T/C cg12927641 chr6:109611667 NA -0.38 -6.62 -0.34 1.42e-10 Reticulocyte fraction of red cells; CRC cis rs9303280 0.870 rs1011082 chr17:38068514 T/C cg11212589 chr17:38028394 ZPBP2 -0.43 -7.94 -0.4 3.25e-14 Self-reported allergy; CRC trans rs2727020 0.930 rs1164686 chr11:49291822 C/T cg03929089 chr4:120376271 NA 0.67 9.35 0.46 1.35e-18 Coronary artery disease; CRC cis rs72945132 0.882 rs7943547 chr11:70133282 C/A cg00319359 chr11:70116639 PPFIA1 0.67 7.4 0.38 1.13e-12 Coronary artery disease; CRC cis rs853679 0.550 rs1225599 chr6:28165190 C/T cg21251018 chr6:28226885 NKAPL 0.46 6.57 0.34 1.97e-10 Depression; CRC cis rs67340775 0.541 rs200973 chr6:27858421 A/G cg06470822 chr6:28175283 NA 0.78 8.18 0.41 6.06e-15 Lung cancer in ever smokers; CRC cis rs2404602 0.552 rs11634428 chr15:77084582 T/C cg23625390 chr15:77176239 SCAPER -0.77 -10.19 -0.49 2.27e-21 Blood metabolite levels; CRC cis rs782590 0.764 rs2586969 chr2:55829392 G/C cg18811423 chr2:55921094 PNPT1 0.79 13.94 0.61 4.99e-35 Metabolic syndrome; CRC cis rs12024301 0.557 rs77882972 chr1:183609281 C/G cg11505048 chr1:183622726 RGL1;APOBEC4 0.8 6.63 0.34 1.39e-10 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs9381040 0.610 rs9381028 chr6:41025081 C/A cg03644281 chr6:41068752 NFYA;LOC221442 -0.44 -6.33 -0.33 8.04e-10 Alzheimer's disease (late onset); CRC cis rs7917772 0.503 rs61871067 chr10:104295382 C/T cg11453585 chr10:104263688 ACTR1A;SUFU 0.89 14.14 0.61 8.48e-36 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC trans rs4276421 0.869 rs11741075 chr5:45556378 C/T cg04793272 chr11:119020941 ABCG4 0.38 5.97 0.31 6.24e-9 P wave duration; CRC trans rs7824557 0.583 rs2263511 chr8:11233318 A/C cg06636001 chr8:8085503 FLJ10661 -0.5 -7.44 -0.38 8.76e-13 Retinal vascular caliber; CRC cis rs875971 1.000 rs4718307 chr7:65610988 A/G cg18912574 chr7:65842487 NCRNA00174 -0.37 -6.4 -0.33 5.31e-10 Aortic root size; CRC trans rs11098499 0.913 rs13126596 chr4:120140729 A/G cg25214090 chr10:38739885 LOC399744 0.51 7.67 0.39 1.95e-13 Corneal astigmatism; CRC cis rs478304 0.934 rs474483 chr11:65520060 T/G cg08755490 chr11:65554678 OVOL1 0.44 6.34 0.33 7.57e-10 Acne (severe); CRC cis rs970548 0.954 rs72796498 chr10:45982219 C/T cg15590007 chr10:45870220 ALOX5 0.47 5.98 0.31 5.8e-9 Total cholesterol levels;Cholesterol, total;HDL cholesterol;HDL cholesterol levels; CRC cis rs79349575 0.745 rs170319 chr17:46991531 T/C cg22482690 chr17:47019901 SNF8 0.48 8.06 0.41 1.48e-14 Type 2 diabetes; CRC cis rs1552244 1.000 rs66797209 chr3:10078526 G/A cg08888203 chr3:10149979 C3orf24 0.73 10.08 0.49 5.45e-21 Alzheimer's disease; CRC cis rs9325144 0.581 rs2730929 chr12:38942739 T/C cg26384229 chr12:38710491 ALG10B -0.51 -7.29 -0.37 2.34e-12 Morning vs. evening chronotype; CRC cis rs10751667 0.666 rs4072741 chr11:976565 T/C cg06064525 chr11:970664 AP2A2 -0.3 -6.06 -0.32 3.68e-9 Alzheimer's disease (late onset); CRC trans rs12478296 1.000 rs55717005 chr2:243041071 T/A cg18288967 chr1:45987694 PRDX1 0.68 7.48 0.38 6.93e-13 Obesity-related traits; CRC cis rs28386778 0.897 rs7221853 chr17:61859836 A/G cg07362569 chr17:61921086 SMARCD2 0.37 5.68 0.3 2.98e-8 Prudent dietary pattern; CRC cis rs4713118 0.955 rs9380011 chr6:27683924 A/G cg19041857 chr6:27730383 NA -0.42 -5.94 -0.31 7.29e-9 Parkinson's disease; CRC cis rs10504229 1.000 rs67913746 chr8:58177825 A/G cg22535103 chr8:58192502 C8orf71 -0.82 -12.27 -0.56 9.63e-29 Developmental language disorder (linguistic errors); CRC cis rs7666738 0.830 rs58696666 chr4:99006913 C/T cg05340658 chr4:99064831 C4orf37 0.61 9.54 0.47 3.44e-19 Colonoscopy-negative controls vs population controls; CRC cis rs1129187 0.755 rs9471985 chr6:42941324 T/C cg21280719 chr6:42927975 GNMT -0.45 -10.17 -0.49 2.57e-21 Alzheimer's disease in APOE e4+ carriers; CRC cis rs992157 0.710 rs10169718 chr2:219103580 C/T cg04731861 chr2:219085781 ARPC2 0.32 6.74 0.35 7.23e-11 Colorectal cancer; CRC cis rs172166 0.561 rs149973 chr6:27983613 G/T cg12273811 chr6:28175739 NA 0.45 6.71 0.35 8.28e-11 Cardiac Troponin-T levels; CRC cis rs9902453 0.904 rs55633288 chr17:28368196 G/A cg26525008 chr17:28256777 EFCAB5;SSH2 -0.69 -11.35 -0.53 2.01e-25 Coffee consumption (cups per day); CRC cis rs9372498 0.505 rs62424204 chr6:118861642 G/A cg15382696 chr6:118971807 C6orf204 0.6 7.78 0.39 9.5e-14 Diastolic blood pressure; CRC cis rs6951245 1.000 rs76214082 chr7:1102097 T/A cg24642844 chr7:1081250 C7orf50 -0.76 -9.16 -0.45 5.78e-18 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs10779751 0.770 rs2275527 chr1:11190646 A/G cg08854313 chr1:11322531 MTOR 0.57 7.38 0.38 1.33e-12 Body mass index; CRC trans rs7937682 0.883 rs486038 chr11:111465963 A/C cg18187862 chr3:45730750 SACM1L 0.43 6.14 0.32 2.38e-9 Primary sclerosing cholangitis; CRC cis rs2281845 0.507 rs942703 chr1:201092979 A/G cg24849736 chr1:201084428 NA -0.46 -6.26 -0.33 1.17e-9 Permanent tooth development; CRC cis rs6709815 0.902 rs13020432 chr2:219668211 C/T cg02176678 chr2:219576539 TTLL4 -0.37 -5.85 -0.31 1.17e-8 Reticulocyte count;High light scatter reticulocyte count; CRC cis rs8177253 1.000 rs8177262 chr3:133480652 A/G cg11941060 chr3:133502564 NA 0.59 10.17 0.49 2.62e-21 Iron status biomarkers; CRC cis rs2404602 0.716 rs7179142 chr15:76698268 G/A cg03037974 chr15:76606532 NA 0.72 12.85 0.58 6.38e-31 Blood metabolite levels; CRC cis rs5750830 0.649 rs4821893 chr22:39797779 G/A cg11247378 chr22:39784982 NA -0.43 -7.97 -0.4 2.7e-14 Intelligence (multi-trait analysis); CRC cis rs6735179 0.641 rs2382558 chr2:1752229 A/G cg19300414 chr2:1746591 PXDN 0.44 7.6 0.39 3.1400000000000003e-13 Response to antipsychotic treatment; CRC cis rs7772486 0.714 rs1883365 chr6:146076749 C/T cg23711669 chr6:146136114 FBXO30 -0.66 -10.97 -0.52 4.52e-24 Lobe attachment (rater-scored or self-reported); CRC cis rs12612619 0.677 rs3754733 chr2:27249245 A/G cg00617064 chr2:27272375 NA -0.38 -6.21 -0.32 1.6e-9 Venous thromboembolism adjusted for sickle cell variant rs77121243-T; CRC trans rs57221529 0.608 rs11749927 chr5:668842 C/T cg25482853 chr8:67687455 SGK3 0.9 11.12 0.52 1.3e-24 Lung disease severity in cystic fibrosis; CRC cis rs7618915 0.501 rs7624716 chr3:52751534 T/C cg08222913 chr3:52553049 STAB1 -0.33 -6.12 -0.32 2.64e-9 Bipolar disorder; CRC cis rs2252790 0.859 rs3053 chr6:116679751 A/T cg18764771 chr6:116381957 FRK -0.22 -6.03 -0.32 4.34e-9 Fast beta electroencephalogram; CRC cis rs763121 0.853 rs1013338 chr22:38974154 C/A cg06022373 chr22:39101656 GTPBP1 0.79 13.24 0.59 2.36e-32 Menopause (age at onset); CRC cis rs597539 0.652 rs579136 chr11:68637476 C/G cg21963583 chr11:68658836 MRPL21 0.59 10.65 0.51 6e-23 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs10540 1.000 rs35255804 chr11:492617 G/A cg03352830 chr11:487213 PTDSS2 0.67 7.7 0.39 1.63e-13 Body mass index; CRC cis rs524281 0.861 rs2293121 chr11:65961347 T/G cg16950941 chr11:66035639 RAB1B -0.62 -7.57 -0.39 3.74e-13 Electroencephalogram traits; CRC cis rs7618915 0.571 rs1961959 chr3:52585760 G/C cg18404041 chr3:52824283 ITIH1 -0.44 -9.07 -0.45 1.09e-17 Bipolar disorder; CRC cis rs950169 1.000 rs12916348 chr15:84765527 C/T cg24253500 chr15:84953950 NA 0.38 6.49 0.34 3.23e-10 Schizophrenia; CRC cis rs7259376 0.902 rs11669353 chr19:22605103 G/C cg02657401 chr19:22469223 NA 0.3 6.54 0.34 2.3e-10 Menopause (age at onset); CRC cis rs2797160 1.000 rs6910933 chr6:126017155 C/G cg05901451 chr6:126070800 HEY2 0.4 6.05 0.32 3.83e-9 Endometrial cancer; CRC cis rs3018066 0.867 rs4569824 chr4:107186200 A/T cg01869342 chr4:106983673 TBCK -0.38 -5.92 -0.31 8.01e-9 Cancer; CRC cis rs72945132 0.882 rs72949081 chr11:70219070 A/G cg00319359 chr11:70116639 PPFIA1 0.66 6.56 0.34 2.1e-10 Coronary artery disease; CRC cis rs172166 0.516 rs1225715 chr6:28113373 C/T cg15786705 chr6:28176104 NA -0.45 -6.6 -0.34 1.64e-10 Cardiac Troponin-T levels; CRC cis rs1348850 0.872 rs12991272 chr2:178457339 T/C cg02961200 chr2:178257176 LOC100130691;AGPS 0.49 6.71 0.35 8.31e-11 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs9393692 0.875 rs9393690 chr6:26271713 A/T cg00631329 chr6:26305371 NA -0.69 -13.45 -0.6 3.75e-33 Educational attainment; CRC cis rs909674 0.524 rs5757670 chr22:39829736 G/A cg24399712 chr22:39784796 NA -0.52 -10.87 -0.51 1.04e-23 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; CRC trans rs1005277 0.579 rs2474599 chr10:38438939 A/G cg23533926 chr12:111358616 MYL2 -0.51 -7.67 -0.39 1.95e-13 Extrinsic epigenetic age acceleration; CRC cis rs981844 0.796 rs11099904 chr4:154681861 A/G cg10279832 chr4:154682576 RNF175 -0.39 -5.71 -0.3 2.54e-8 Response to statins (LDL cholesterol change); CRC cis rs35110281 0.807 rs4818850 chr21:45028071 T/G cg04455712 chr21:45112962 RRP1B 0.39 7.57 0.39 3.7e-13 Mean corpuscular volume; CRC cis rs17162190 0.698 rs3816539 chr1:26786627 G/A cg17456097 chr1:26900765 RPS6KA1 0.47 6.62 0.34 1.5e-10 Mean corpuscular volume; CRC cis rs9916302 0.821 rs1966915 chr17:37425262 A/C cg03013999 chr17:37608204 MED1 0.48 7.43 0.38 9.6e-13 Glomerular filtration rate (creatinine); CRC trans rs6703335 0.870 rs10803142 chr1:243598234 A/G cg22039215 chr3:195716632 SDHAP1 0.43 6.04 0.32 4.1e-9 Schizophrenia;Schizophrenia, schizoaffective disorder or bipolar disorder; CRC cis rs950169 0.800 rs4842847 chr15:84931199 G/A cg11189052 chr15:85197271 WDR73 0.64 8.93 0.44 3.1e-17 Schizophrenia; CRC cis rs11971779 0.680 rs7788777 chr7:139055193 G/C cg23387468 chr7:139079360 LUC7L2 0.41 7.02 0.36 1.3e-11 Diisocyanate-induced asthma; CRC cis rs720844 0.554 rs16828786 chr2:149296672 A/G cg09247360 chr2:149335327 NA -0.42 -5.7 -0.3 2.62e-8 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs6570726 0.846 rs6899900 chr6:145883873 T/G cg13319975 chr6:146136371 FBXO30 -0.43 -6.39 -0.33 5.79e-10 Lobe attachment (rater-scored or self-reported); CRC cis rs3087591 0.960 rs2952979 chr17:29474298 T/A cg24425628 chr17:29625626 OMG;NF1 0.86 15.9 0.66 1.21e-42 Hip circumference; CRC cis rs62244186 0.748 rs4682987 chr3:44674996 C/T cg11003573 chr3:44754125 ZNF502 -0.37 -6.36 -0.33 6.86e-10 Depressive symptoms; CRC cis rs13418410 0.539 rs1545399 chr2:33843801 A/G cg04131969 chr2:33951647 MYADML -0.66 -9.8 -0.48 4.52e-20 Non-response to antidepressants and depression; CRC cis rs10752881 1.000 rs8179282 chr1:182974598 C/G ch.1.3577855R chr1:183094577 LAMC1 0.87 15.17 0.64 8.98e-40 Colorectal cancer; CRC cis rs763121 0.853 rs2205802 chr22:39046327 T/C cg06544989 chr22:39130855 UNC84B 0.44 6.84 0.35 3.76e-11 Menopause (age at onset); CRC cis rs10504229 0.775 rs55764517 chr8:58158238 G/A cg21724239 chr8:58056113 NA 0.64 8.48 0.42 8e-16 Developmental language disorder (linguistic errors); CRC trans rs7613875 0.600 rs2624832 chr3:50030858 C/T cg21665057 chr3:196295764 WDR53;FBXO45 0.43 6.26 0.33 1.17e-9 Body mass index; CRC cis rs7737355 0.947 rs32110 chr5:131045835 T/C cg06307176 chr5:131281290 NA 0.43 6.19 0.32 1.79e-9 Life satisfaction; CRC trans rs1814175 0.653 rs10839480 chr11:50034556 C/T cg03929089 chr4:120376271 NA -0.93 -17.98 -0.7 7.84e-51 Height; CRC cis rs76878669 0.561 rs4930178 chr11:66129442 C/G cg24851651 chr11:66362959 CCS -0.38 -6.54 -0.34 2.3e-10 Educational attainment (years of education); CRC cis rs12024301 0.557 rs2231241 chr1:183596703 G/A cg11505048 chr1:183622726 RGL1;APOBEC4 0.72 6.52 0.34 2.64e-10 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs7493 1.000 rs6968305 chr7:95042529 G/A cg21856205 chr7:94953877 PON1 -0.49 -6.29 -0.33 1.03e-9 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs939658 0.728 rs12904789 chr15:79412589 G/A cg17916960 chr15:79447300 NA -0.41 -6.34 -0.33 7.6e-10 Refractive error; CRC cis rs12325245 0.536 rs34737210 chr16:58549262 T/C cg19824325 chr16:58548873 SETD6 0.96 6.28 0.33 1.08e-9 Schizophrenia; CRC cis rs9527 0.590 rs7089680 chr10:104802071 C/T cg15744005 chr10:104629667 AS3MT 0.29 5.83 0.31 1.32e-8 Arsenic metabolism; CRC cis rs2180341 0.960 rs7756884 chr6:127684018 A/G cg24812749 chr6:127587940 RNF146 0.95 13.32 0.59 1.16e-32 Breast cancer; CRC cis rs9311676 0.656 rs3191903 chr3:58382846 C/T cg06643156 chr3:58380774 PXK 0.41 6.33 0.33 7.82e-10 Systemic lupus erythematosus; CRC cis rs877282 0.898 rs12357016 chr10:765675 C/T cg06581033 chr10:766294 NA -0.53 -5.79 -0.3 1.61e-8 Uric acid levels; CRC cis rs11677416 1.000 rs11677416 chr2:113529240 A/G cg27083787 chr2:113543245 IL1A 0.47 6.58 0.34 1.82e-10 Response to antipsychotic treatment in schizophrenia (working memory); CRC cis rs10504229 0.683 rs2318144 chr8:58114743 G/A cg24829409 chr8:58192753 C8orf71 -0.61 -7.74 -0.39 1.24e-13 Developmental language disorder (linguistic errors); CRC trans rs10982213 0.830 rs2274163 chr9:117188714 C/T cg17169982 chr17:80787973 TBCD;ZNF750 0.42 6.43 0.33 4.39e-10 Interleukin-6 levels; CRC cis rs6599388 0.803 rs11248057 chr4:906131 C/G cg23992470 chr4:843637 GAK 0.47 7.27 0.37 2.64e-12 Parkinson's disease; CRC cis rs2404602 0.622 rs11637296 chr15:77207885 C/A cg03037974 chr15:76606532 NA -0.53 -7.26 -0.37 2.8e-12 Blood metabolite levels; CRC cis rs2230307 0.536 rs534252 chr1:100472604 A/G cg24955406 chr1:100503596 HIAT1 0.59 7.13 0.37 6.35e-12 Carotid intima media thickness; CRC cis rs12699477 0.545 rs117125814 chr7:1910681 T/G cg00106254 chr7:1943704 MAD1L1 -0.47 -7.3 -0.37 2.2e-12 Testicular germ cell tumor; CRC cis rs11098499 0.738 rs28687057 chr4:120280812 A/G cg09307838 chr4:120376055 NA 0.68 10.53 0.5 1.51e-22 Corneal astigmatism; CRC cis rs12410462 0.581 rs7547204 chr1:227560909 C/T cg04117972 chr1:227635322 NA 0.66 6.06 0.32 3.81e-9 Major depressive disorder; CRC cis rs11190604 1.000 rs3793772 chr10:102222825 A/G cg16342193 chr10:102329863 NA -0.36 -5.93 -0.31 7.45e-9 Palmitoleic acid (16:1n-7) levels; CRC cis rs6952808 0.723 rs4721295 chr7:2036669 G/T cg00106254 chr7:1943704 MAD1L1 0.52 7.91 0.4 4.04e-14 Bipolar disorder and schizophrenia; CRC trans rs1005277 0.579 rs2504143 chr10:38383706 C/T cg23533926 chr12:111358616 MYL2 -0.53 -7.89 -0.4 4.42e-14 Extrinsic epigenetic age acceleration; CRC cis rs9399135 0.967 rs6902438 chr6:135336587 C/T cg24558204 chr6:135376177 HBS1L 0.52 8.21 0.41 5.05e-15 Red blood cell count; CRC cis rs2425143 1.000 rs2425141 chr20:34350123 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.48 -6.16 -0.32 2.11e-9 Blood protein levels; CRC cis rs28386778 0.897 rs968719 chr17:61908271 C/T cg06873352 chr17:61820015 STRADA 0.84 15.17 0.64 8.56e-40 Prudent dietary pattern; CRC cis rs6502050 0.835 rs8077772 chr17:80117220 A/G cg11859384 chr17:80120422 CCDC57 0.36 5.71 0.3 2.59e-8 Life satisfaction; CRC cis rs11123610 0.520 rs11682697 chr2:3721127 A/G cg25251562 chr2:3704773 ALLC -0.49 -6.16 -0.32 2.09e-9 Response to inhaled corticosteroid treatment in asthma (change in FEV1); CRC cis rs3087591 0.960 rs2269855 chr17:29482878 G/A cg24425628 chr17:29625626 OMG;NF1 0.83 15.37 0.65 1.41e-40 Hip circumference; CRC cis rs4713118 0.869 rs6902689 chr6:27709441 C/T cg21251018 chr6:28226885 NKAPL 0.38 5.63 0.3 3.79e-8 Parkinson's disease; CRC cis rs1348850 0.750 rs55792594 chr2:178496468 C/T cg22681709 chr2:178499509 PDE11A -0.41 -7.54 -0.38 4.59e-13 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs9910055 0.529 rs575798 chr17:42181796 A/C cg09913183 chr17:42254507 C17orf65;ASB16 -0.49 -6.63 -0.34 1.34e-10 Total body bone mineral density; CRC trans rs35110281 0.748 rs9981460 chr21:45030965 T/A cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.52 8.64 0.43 2.42e-16 Mean corpuscular volume; CRC trans rs11088226 0.681 rs2833895 chr21:33929802 G/A cg09050820 chr6:167586206 TCP10L2 0.84 9.01 0.44 1.66e-17 Gastritis; CRC cis rs6502050 0.731 rs11867299 chr17:80088675 C/A cg13198984 chr17:80129470 CCDC57 0.47 8.45 0.42 9.24e-16 Life satisfaction; CRC cis rs6692209 1 rs6692209 chr1:152506444 C/T cg09873164 chr1:152488093 CRCT1 0.38 6.3 0.33 9.41e-10 Plantar warts; CRC trans rs3808502 0.549 rs1382563 chr8:11426790 C/G cg16141378 chr3:129829833 LOC729375 -0.46 -7.14 -0.37 6.09e-12 Neuroticism; CRC cis rs7259376 0.902 rs11879678 chr19:22607312 C/A cg02657401 chr19:22469223 NA 0.31 6.67 0.35 1.07e-10 Menopause (age at onset); CRC cis rs6940638 0.688 rs9295730 chr6:27128806 T/C cg12292205 chr6:26970375 C6orf41 -0.49 -6.74 -0.35 6.97e-11 Intelligence (multi-trait analysis); CRC cis rs10752881 0.933 rs2027086 chr1:183057933 G/A ch.1.3577855R chr1:183094577 LAMC1 0.84 14.59 0.63 1.52e-37 Colorectal cancer; CRC cis rs4665809 0.590 rs13019536 chr2:26526978 C/A cg25036284 chr2:26402008 FAM59B -0.5 -6.51 -0.34 2.87e-10 Gut microbiome composition (summer); CRC cis rs1707322 0.963 rs10789484 chr1:46406978 G/C cg06784218 chr1:46089804 CCDC17 0.51 9.08 0.45 1.02e-17 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs1930961 1.000 rs6004667 chr22:25874464 A/G cg13472656 chr22:25960710 ADRBK2 -0.52 -5.7 -0.3 2.65e-8 Bipolar disorder with mood-incongruent psychosis; CRC cis rs9467773 1.000 rs9467796 chr6:26568411 A/G cg09904177 chr6:26538194 HMGN4 0.86 14.82 0.63 2.06e-38 Intelligence (multi-trait analysis); CRC cis rs763014 0.593 rs28455838 chr16:681966 T/C cg04562611 chr16:615315 C16orf11 0.35 5.88 0.31 9.85e-9 Height; CRC cis rs12519773 0.501 rs4321736 chr5:92533363 C/T cg18783429 chr5:92414398 NA 0.28 5.9 0.31 9.09e-9 Migraine; CRC cis rs9818758 0.607 rs11710247 chr3:49249800 G/T cg00383909 chr3:49044727 WDR6 1.07 10.66 0.51 5.43e-23 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; CRC cis rs2576037 0.623 rs2576040 chr18:44582027 A/G cg19077165 chr18:44547161 KATNAL2 0.62 10.32 0.49 8.41e-22 Personality dimensions; CRC trans rs9929218 0.817 rs3114400 chr16:68719430 C/T cg04657470 chr2:198365150 HSPE1;HSPD1 -1.06 -16.04 -0.66 3.67e-43 Colorectal cancer; CRC cis rs6547741 0.904 rs2384628 chr2:27774702 T/G cg27432699 chr2:27873401 GPN1 0.78 14.28 0.62 2.41e-36 Oral cavity cancer; CRC cis rs13256369 0.755 rs12550057 chr8:8562268 G/A cg00074818 chr8:8560427 CLDN23 0.39 7.05 0.36 1.04e-11 Obesity-related traits; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg27238079 chr10:33247273 ITGB1 -0.37 -5.98 -0.31 5.72e-9 Myopia (pathological); CRC cis rs7618501 0.540 rs11130241 chr3:50131459 A/T cg24308560 chr3:49941425 MST1R 0.48 7.6 0.39 3.19e-13 Intelligence (multi-trait analysis); CRC cis rs400736 0.859 rs379920 chr1:8028865 G/C cg25007680 chr1:8021821 PARK7 0.56 7.59 0.39 3.32e-13 Response to antidepressants and depression; CRC cis rs7100689 0.622 rs10749595 chr10:82172975 C/T cg00277334 chr10:82204260 NA -0.44 -5.8 -0.3 1.55e-8 Post bronchodilator FEV1; CRC cis rs4243830 0.737 rs7552172 chr1:6612269 C/T cg22792644 chr1:6614718 TAS1R1;NOL9 -0.81 -9.88 -0.48 2.55e-20 Body mass index; CRC cis rs7394190 0.748 rs11000772 chr10:75533988 T/G cg07699608 chr10:75541558 CHCHD1 0.61 6.37 0.33 6.53e-10 Incident atrial fibrillation; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg09514589 chr15:76603992 ETFA 0.43 6.08 0.32 3.38e-9 Response to antipsychotic treatment; CRC cis rs9487051 0.768 rs442405 chr6:109526980 T/G cg01475377 chr6:109611718 NA -0.34 -5.9 -0.31 9.23e-9 Reticulocyte fraction of red cells; CRC cis rs916888 0.821 rs70600 chr17:44860021 C/T cg15921436 chr17:44337874 NA 0.73 8.06 0.41 1.38e-14 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs1577917 0.655 rs9450311 chr6:86376586 G/A cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A 0.53 7.47 0.38 7.26e-13 Response to antipsychotic treatment; CRC trans rs8108034 1.000 rs39587 chr19:39806997 C/T cg22438603 chr5:127418940 SLC12A2;FLJ33630 -0.56 -6.05 -0.32 3.96e-9 Lung adenocarcinoma; CRC cis rs1129187 0.837 rs3763236 chr6:42902508 C/T cg05552183 chr6:42928497 GNMT -0.44 -6.77 -0.35 6.04e-11 Alzheimer's disease in APOE e4+ carriers; CRC cis rs7980687 0.550 rs1727324 chr12:123698603 A/T cg00376283 chr12:123451042 ABCB9 0.59 6.83 0.35 4.23e-11 Height;Educational attainment;Head circumference (infant); CRC cis rs853679 0.505 rs200992 chr6:27814677 A/G cg19041857 chr6:27730383 NA -0.77 -6.96 -0.36 1.81e-11 Depression; CRC cis rs2019137 0.936 rs2305133 chr2:113956821 C/G cg21550016 chr2:113992930 PAX8;LOC440839;LOC654433 -0.51 -7.29 -0.37 2.32e-12 Lymphocyte counts; CRC cis rs9372498 0.505 rs62422250 chr6:118990182 T/C cg24463073 chr6:118973353 C6orf204 0.48 5.85 0.31 1.18e-8 Diastolic blood pressure; CRC cis rs6662572 0.806 rs56067046 chr1:46044314 C/T cg08644498 chr1:46502608 NA 0.49 7.02 0.36 1.26e-11 Blood protein levels; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg22595711 chr4:83351836 ENOPH1;HNRPDL 0.47 6.65 0.34 1.24e-10 Response to antipsychotic treatment; CRC cis rs11148252 0.846 rs7985262 chr13:52997161 C/T cg02158880 chr13:53174818 NA 0.49 7.37 0.38 1.37e-12 Lewy body disease; CRC cis rs908922 0.676 rs1970283 chr1:152495619 G/C cg23254163 chr1:152506842 NA 0.46 9.0 0.44 1.84e-17 Hair morphology; CRC cis rs9549260 0.753 rs9549243 chr13:41217205 G/A cg21288729 chr13:41239152 FOXO1 0.49 6.26 0.33 1.19e-9 Red blood cell count; CRC cis rs1862618 0.754 rs252899 chr5:56188569 G/C cg24531977 chr5:56204891 C5orf35 -0.86 -11.11 -0.52 1.51e-24 Initial pursuit acceleration; CRC cis rs1448094 0.511 rs61930582 chr12:86157387 T/C cg18827107 chr12:86230957 RASSF9 -0.41 -6.18 -0.32 1.89e-9 Major depressive disorder; CRC trans rs4263408 0.934 rs9683743 chr4:39703194 A/C cg00834779 chr19:12036415 ZNF700 -0.41 -6.23 -0.32 1.42e-9 Plasma amyloid beta peptide concentrations (ABx-40); CRC trans rs6550704 0.687 rs9865314 chr3:22634337 A/G cg23408836 chr2:170590490 KLHL23 -0.42 -6.25 -0.33 1.26e-9 Daytime sleep phenotypes; CRC cis rs9467711 0.516 rs1165168 chr6:25859508 A/C cg08501292 chr6:25962987 TRIM38 0.64 6.68 0.35 1.04e-10 Autism spectrum disorder or schizophrenia; CRC trans rs66573146 1.000 rs73202122 chr4:7005594 G/A cg07817883 chr1:32538562 TMEM39B 1.68 13.33 0.59 1.01e-32 Granulocyte percentage of myeloid white cells; CRC trans rs61931739 0.534 rs4931772 chr12:34044590 G/A cg26384229 chr12:38710491 ALG10B 0.51 6.88 0.35 3.1e-11 Morning vs. evening chronotype; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg22212156 chr20:32031449 SNTA1 -0.39 -5.99 -0.31 5.53e-9 Myopia (pathological); CRC cis rs7591163 0.883 rs11891398 chr2:228723357 C/T cg08034379 chr2:228736324 WDR69 -0.49 -6.75 -0.35 6.83e-11 Blood pressure; CRC cis rs1218582 0.772 rs2102423 chr1:154916068 A/G cg09359103 chr1:154839909 KCNN3 -0.69 -11.95 -0.55 1.38e-27 Prostate cancer; CRC cis rs2933343 0.533 rs11915889 chr3:128700866 A/C cg11901034 chr3:128598214 ACAD9 -0.59 -7.83 -0.4 6.55e-14 IgG glycosylation; CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg00852613 chr13:50159829 RCBTB1 0.39 6.29 0.33 1.03e-9 Obesity-related traits; CRC cis rs2795502 0.938 rs3121324 chr10:43379515 C/T cg27426351 chr10:43362370 NA 0.49 6.18 0.32 1.89e-9 Blood protein levels; CRC cis rs853679 1.000 rs6901575 chr6:28250984 G/A cg03623178 chr6:28175578 NA 0.74 7.48 0.38 6.79e-13 Depression; CRC cis rs10927875 0.722 rs945425 chr1:16348412 T/C cg21385522 chr1:16154831 NA 0.62 7.65 0.39 2.23e-13 Dilated cardiomyopathy; CRC cis rs9926296 0.533 rs12102290 chr16:89812617 C/T cg27121462 chr16:89883253 FANCA 0.56 8.66 0.43 2.17e-16 Vitiligo; CRC cis rs4936891 0.577 rs1453650 chr11:123921929 A/G cg22125253 chr11:123886957 OR10G4 -0.34 -6.17 -0.32 2e-9 Male fertility; CRC cis rs713587 1.000 rs713587 chr2:25158281 C/T cg22495460 chr2:25135724 ADCY3 -0.76 -13.74 -0.6 2.77e-34 Body mass index in non-asthmatics; CRC cis rs2836974 0.932 rs73221193 chr21:40554693 C/T cg17971929 chr21:40555470 PSMG1 0.83 11.82 0.55 4.02e-27 Cognitive function; CRC cis rs7208859 0.673 rs2269916 chr17:29233763 A/G cg14008862 chr17:28927542 LRRC37B2 0.55 5.75 0.3 2.04e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs3736485 0.934 rs17609812 chr15:51879260 G/A cg08986416 chr15:51914746 DMXL2 -0.46 -6.56 -0.34 2.11e-10 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC trans rs1814175 0.647 rs28456013 chr11:50047629 T/C cg03929089 chr4:120376271 NA -0.75 -12.26 -0.56 1.02e-28 Height; CRC cis rs4713118 0.615 rs9348772 chr6:27656090 G/T cg02683197 chr6:28174875 NA 0.55 7.76 0.39 1.05e-13 Parkinson's disease; CRC cis rs7552404 0.924 rs3818855 chr1:76198785 C/T cg22875332 chr1:76189707 ACADM 0.74 11.1 0.52 1.62e-24 Blood metabolite levels;Acylcarnitine levels; CRC cis rs17234274 0.644 rs7949847 chr11:23222440 C/G cg05245346 chr11:23248277 NA 0.35 5.75 0.3 2.02e-8 Cancer; CRC cis rs13256369 1.000 rs873063 chr8:8572447 A/G cg06671706 chr8:8559999 CLDN23 0.56 8.16 0.41 7e-15 Obesity-related traits; CRC cis rs1552244 0.882 rs3732966 chr3:10015740 C/T cg02579736 chr3:10068473 FANCD2;CIDECP 0.93 11.94 0.55 1.55e-27 Alzheimer's disease; CRC cis rs1997103 1.000 rs10228182 chr7:55406695 A/T cg17469321 chr7:55412551 NA 0.72 11.28 0.53 3.48e-25 QRS interval (sulfonylurea treatment interaction); CRC trans rs3733585 0.699 rs6449176 chr4:9967843 G/A cg26043149 chr18:55253948 FECH -0.49 -7.51 -0.38 5.78e-13 Cleft plate (environmental tobacco smoke interaction); CRC cis rs7927771 0.965 rs12364432 chr11:47902883 G/A cg05585544 chr11:47624801 NA -0.61 -10.64 -0.51 6.26e-23 Subjective well-being; CRC trans rs11039798 0.588 rs1847640 chr11:49004025 C/T cg03929089 chr4:120376271 NA 0.63 6.5 0.34 2.94e-10 Axial length; CRC cis rs4711350 0.954 rs943464 chr6:33731469 A/G cg07979401 chr6:33739406 LEMD2 0.48 6.09 0.32 3.16e-9 Schizophrenia; CRC cis rs796364 0.806 rs79333757 chr2:200915716 T/C cg25936922 chr2:200820526 C2orf60;C2orf47 -0.7 -6.57 -0.34 2.02e-10 Schizophrenia; CRC cis rs7590720 1.000 rs934154 chr2:216901933 C/T cg12620499 chr2:216877984 MREG 0.86 14.23 0.62 3.68e-36 Alcohol dependence; CRC cis rs17095355 1.000 rs17126877 chr10:111672786 C/T cg00817464 chr10:111662876 XPNPEP1 -0.53 -6.06 -0.32 3.66e-9 Biliary atresia; CRC cis rs6665290 0.904 rs2297416 chr1:227172935 C/G cg10327440 chr1:227177885 CDC42BPA -1.04 -22.52 -0.78 1.34e-68 Myeloid white cell count; CRC cis rs2204008 0.837 rs12369089 chr12:38060263 G/A cg13010199 chr12:38710504 ALG10B 0.44 5.64 0.3 3.74e-8 Bladder cancer; CRC cis rs10744422 1.000 rs10744434 chr12:123368419 T/A cg25930673 chr12:123319894 HIP1R -0.53 -5.67 -0.3 3.07e-8 Schizophrenia; CRC cis rs8072100 1.000 rs8065437 chr17:45721653 C/T cg25173405 chr17:45401733 C17orf57 -0.46 -7.22 -0.37 3.6e-12 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs7772486 0.686 rs857880 chr6:145971115 T/C cg13319975 chr6:146136371 FBXO30 0.45 6.71 0.35 8.7e-11 Lobe attachment (rater-scored or self-reported); CRC cis rs9311474 0.508 rs7614498 chr3:52618941 A/T cg18099408 chr3:52552593 STAB1 -0.49 -8.36 -0.42 1.84e-15 Electroencephalogram traits; CRC cis rs868943 0.714 rs13193683 chr6:116356235 A/T cg18764771 chr6:116381957 FRK 0.26 6.25 0.33 1.26e-9 Total cholesterol levels; CRC cis rs896854 0.654 rs13274945 chr8:95986626 C/T cg16049864 chr8:95962084 TP53INP1 -0.65 -11.81 -0.55 4.53e-27 Type 2 diabetes; CRC cis rs11785400 0.793 rs9297970 chr8:143723386 C/T cg24634471 chr8:143751801 JRK 0.51 7.08 0.36 8.81e-12 Schizophrenia; CRC cis rs7811142 0.830 rs75636500 chr7:99947657 C/G cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.09 14.36 0.62 1.17e-36 Platelet count; CRC cis rs4285028 0.747 rs1920299 chr3:121593769 A/G cg11130432 chr3:121712080 ILDR1 0.5 6.15 0.32 2.19e-9 Multiple sclerosis; CRC cis rs4713118 0.615 rs9348772 chr6:27656090 G/T cg20933634 chr6:27740509 NA 0.39 5.65 0.3 3.39e-8 Parkinson's disease; CRC cis rs9911578 0.967 rs2429369 chr17:56501420 A/G cg05425664 chr17:57184151 TRIM37 -0.49 -7.5 -0.38 6e-13 Intelligence (multi-trait analysis); CRC cis rs35110281 0.748 rs2838324 chr21:44999820 T/C cg01579765 chr21:45077557 HSF2BP -0.37 -7.1 -0.36 7.67e-12 Mean corpuscular volume; CRC cis rs4713118 0.621 rs4713133 chr6:28034041 T/C cg12273811 chr6:28175739 NA 0.63 8.16 0.41 7.43e-15 Parkinson's disease; CRC cis rs7927771 1.000 rs12421210 chr11:47779586 C/T cg18512352 chr11:47633146 NA -0.49 -9.48 -0.46 5.08e-19 Subjective well-being; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg27570636 chr1:214454189 SMYD2 0.43 6.22 0.32 1.49e-9 Response to antipsychotic treatment; CRC cis rs10504229 0.683 rs16921829 chr8:58110950 A/G cg02290350 chr8:58132656 NA -0.6 -8.4 -0.42 1.33e-15 Developmental language disorder (linguistic errors); CRC cis rs7737355 0.947 rs4706028 chr5:130946227 T/C cg06307176 chr5:131281290 NA 0.45 6.48 0.34 3.34e-10 Life satisfaction; CRC trans rs11250098 0.548 rs7837038 chr8:10783074 G/A cg06636001 chr8:8085503 FLJ10661 -0.55 -8.09 -0.41 1.18e-14 Morning vs. evening chronotype; CRC cis rs12200560 0.505 rs211172 chr6:97070691 C/A cg06623918 chr6:96969491 KIAA0776 0.48 7.0 0.36 1.42e-11 Coronary heart disease; CRC cis rs10883723 0.810 rs7092622 chr10:104249919 T/G cg11453585 chr10:104263688 ACTR1A;SUFU 0.91 17.11 0.69 2.18e-47 Allergic disease (asthma, hay fever or eczema); CRC cis rs7255436 0.965 rs7249624 chr19:8446135 G/A cg10174797 chr19:8464628 RAB11B 0.44 7.51 0.38 5.6e-13 HDL cholesterol; CRC cis rs9660180 0.935 rs2180311 chr1:1748734 T/C cg23982607 chr1:1823379 GNB1 -0.88 -15.94 -0.66 8.97e-43 Body mass index; CRC cis rs208520 0.690 rs12208310 chr6:66730108 G/C cg07460842 chr6:66804631 NA 1.06 14.77 0.63 3.26e-38 Exhaled nitric oxide output; CRC cis rs875971 0.545 rs313828 chr7:65552614 T/C cg18876405 chr7:65276391 NA -0.45 -6.06 -0.32 3.74e-9 Aortic root size; CRC cis rs4481887 0.888 rs4525076 chr1:248456876 T/G cg00666640 chr1:248458726 OR2T12 0.55 9.83 0.48 3.7e-20 Common traits (Other); CRC cis rs1519814 1.000 rs4871045 chr8:121167814 T/C cg22335954 chr8:121166405 COL14A1 -0.58 -6.73 -0.35 7.65e-11 Breast cancer; CRC cis rs28374715 0.532 rs7168431 chr15:41672384 A/G cg18705301 chr15:41695430 NDUFAF1 -1.13 -18.76 -0.72 6.3e-54 Ulcerative colitis; CRC cis rs4819052 0.851 rs9979545 chr21:46679805 G/A cg19498844 chr21:46707878 POFUT2;LOC642852 0.76 11.1 0.52 1.62e-24 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs9479482 0.967 rs763574 chr6:150349415 G/C cg25797454 chr6:150327115 RAET1K 0.38 6.49 0.34 3.13e-10 Alopecia areata; CRC cis rs12474201 0.630 rs897529 chr2:46948175 T/C cg06386533 chr2:46925753 SOCS5 0.66 10.72 0.51 3.5e-23 Height; CRC trans rs2303319 0.504 rs62189046 chr2:162612371 C/G cg10272801 chr16:14013773 ERCC4 -0.68 -6.07 -0.32 3.49e-9 Cognitive function; CRC trans rs7618501 0.572 rs4688756 chr3:50040194 T/A cg21665057 chr3:196295764 WDR53;FBXO45 0.53 8.21 0.41 4.97e-15 Intelligence (multi-trait analysis); CRC cis rs4243830 0.850 rs4908912 chr1:6599558 A/C cg22792644 chr1:6614718 TAS1R1;NOL9 -0.7 -7.89 -0.4 4.52e-14 Body mass index; CRC cis rs9311676 0.632 rs62259780 chr3:58428078 T/G cg06643156 chr3:58380774 PXK 0.43 6.53 0.34 2.5e-10 Systemic lupus erythematosus; CRC cis rs10504229 0.773 rs1874373 chr8:58194423 T/C cg22535103 chr8:58192502 C8orf71 -0.73 -10.96 -0.52 4.78e-24 Developmental language disorder (linguistic errors); CRC trans rs9951602 1.000 rs1903723 chr18:76646571 A/G cg02800362 chr5:177631904 HNRNPAB 0.77 8.2 0.41 5.27e-15 Obesity-related traits; CRC cis rs651907 0.557 rs11914318 chr3:101453858 C/T cg11279151 chr3:101281821 RG9MTD1 -0.54 -7.4 -0.38 1.12e-12 Colorectal cancer; CRC cis rs11249608 0.789 rs7700958 chr5:178436617 G/A cg01312482 chr5:178451176 ZNF879 -0.35 -5.93 -0.31 7.85e-9 Pubertal anthropometrics; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg20791669 chr3:190232025 IL1RAP 0.48 6.2 0.32 1.74e-9 Thyroid stimulating hormone; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg25385272 chr1:222763149 TAF1A 0.48 6.13 0.32 2.57e-9 Thyroid stimulating hormone; CRC cis rs2404602 0.647 rs11072612 chr15:76960984 A/T cg03037974 chr15:76606532 NA -0.54 -8.08 -0.41 1.29e-14 Blood metabolite levels; CRC cis rs7224737 1.000 rs2014521 chr17:40283413 C/G cg20291162 chr17:40259547 DHX58 -0.55 -7.98 -0.4 2.46e-14 Fibrinogen levels; CRC cis rs2073300 0.609 rs6137936 chr20:23385232 C/T cg12062639 chr20:23401060 NAPB 0.8 7.17 0.37 4.9e-12 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs2075371 0.501 rs1421469 chr7:134028260 C/G cg20476274 chr7:133979776 SLC35B4 0.57 8.79 0.44 8.75e-17 Mean platelet volume; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg00596521 chr2:175260560 CIR1;SCRN3 0.39 6.69 0.35 9.37e-11 Liver disease severity in Alagille syndrome; CRC cis rs6540556 0.682 rs2282741 chr1:209900609 G/C cg23920097 chr1:209922102 NA -0.47 -5.67 -0.3 3.11e-8 Red blood cell count; CRC cis rs10503871 0.545 rs7822088 chr8:30498193 G/A cg26383811 chr8:30366931 RBPMS 0.4 5.65 0.3 3.4e-8 Metabolite levels (X-11787); CRC cis rs7043114 0.525 rs4744136 chr9:95275024 A/G cg14631576 chr9:95140430 CENPP 0.31 5.81 0.31 1.47e-8 Height; CRC cis rs11758351 1.000 rs11758351 chr6:26203910 T/G cg01420254 chr6:26195488 NA 0.79 8.63 0.43 2.66e-16 Gout;Renal underexcretion gout; CRC cis rs13256369 0.802 rs12680019 chr8:8561698 A/G cg17143192 chr8:8559678 CLDN23 0.51 6.57 0.34 2.01e-10 Obesity-related traits; CRC cis rs28386778 1.000 rs3020613 chr17:61955983 A/G cg06601766 chr17:61851465 DDX42;CCDC47 0.44 6.03 0.32 4.29e-9 Prudent dietary pattern; CRC cis rs2630709 0.562 rs3097267 chr2:8466157 A/G cg12167548 chr2:8464763 NA -0.35 -6.85 -0.35 3.59e-11 Monocyte percentage of white cells; CRC cis rs3768617 0.610 rs10911228 chr1:183049792 T/C ch.1.3577855R chr1:183094577 LAMC1 0.61 8.92 0.44 3.34e-17 Fuchs's corneal dystrophy; CRC cis rs1992660 0.528 rs6883302 chr5:40411414 C/T cg09067459 chr5:40385259 NA 0.44 7.59 0.39 3.31e-13 Crohn's disease; CRC cis rs1499614 1.000 rs2707828 chr7:66171377 G/A cg25985355 chr7:65971099 NA -0.52 -5.92 -0.31 7.91e-9 Gout; CRC cis rs8031584 0.958 rs11293 chr15:31234981 G/A cg08704250 chr15:31115839 NA -0.44 -7.99 -0.4 2.28e-14 Huntington's disease progression; CRC cis rs4665809 0.818 rs35413760 chr2:26267137 C/A cg22920501 chr2:26401640 FAM59B 0.56 6.51 0.34 2.74e-10 Gut microbiome composition (summer); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg26807643 chr1:11741683 MAD2L2 0.41 6.14 0.32 2.39e-9 Response to antipsychotic treatment; CRC cis rs17376456 0.825 rs67328989 chr5:93243133 T/A cg21475434 chr5:93447410 FAM172A 0.81 8.17 0.41 6.68e-15 Diabetic retinopathy; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg15793563 chr11:910950 CHID1 0.4 7.06 0.36 1.01e-11 Liver disease severity in Alagille syndrome; CRC cis rs55882075 0.730 rs10794700 chr5:179148335 C/G cg14593053 chr5:179126677 CANX 0.49 7.69 0.39 1.73e-13 Monocyte percentage of white cells; CRC cis rs2050392 0.517 rs2480299 chr10:30743197 G/A cg25182066 chr10:30743637 MAP3K8 -0.61 -8.76 -0.43 1.05e-16 Inflammatory bowel disease; CRC cis rs7772486 0.790 rs6926076 chr6:146232804 C/T cg23711669 chr6:146136114 FBXO30 -0.72 -12.64 -0.57 3.92e-30 Lobe attachment (rater-scored or self-reported); CRC cis rs2153535 0.580 rs1319169 chr6:8464456 G/A cg07606381 chr6:8435919 SLC35B3 0.68 10.9 0.51 8.26e-24 Motion sickness; CRC cis rs6460942 0.524 rs6948366 chr7:12369905 A/G cg20607287 chr7:12443886 VWDE -0.5 -7.0 -0.36 1.47e-11 Coronary artery disease; CRC cis rs12586317 0.547 rs60152856 chr14:35421373 G/A cg16230307 chr14:35515116 FAM177A1 0.83 9.66 0.47 1.31e-19 Psoriasis; CRC cis rs17270561 0.636 rs3922681 chr6:25698481 C/T cg17691542 chr6:26056736 HIST1H1C 0.62 7.57 0.39 3.68e-13 Iron status biomarkers; CRC cis rs941408 0.515 rs12610096 chr19:2778129 C/T cg06609049 chr19:2785107 THOP1 1.1 18.48 0.71 8.34e-53 Total cholesterol levels; CRC cis rs875971 1.000 rs811880 chr7:65818646 T/C cg12463550 chr7:65579703 CRCP 0.49 7.04 0.36 1.15e-11 Aortic root size; CRC cis rs7666738 0.830 rs116103936 chr4:98954531 T/C cg17366294 chr4:99064904 C4orf37 0.43 7.34 0.38 1.69e-12 Colonoscopy-negative controls vs population controls; CRC trans rs10021731 0.718 rs28766989 chr4:115410908 C/T cg25927708 chr2:119603813 EN1 -0.33 -6.01 -0.31 4.92e-9 Optic disc area; CRC cis rs597539 0.690 rs578791 chr11:68625809 C/T cg06112835 chr11:68658793 MRPL21 0.46 7.41 0.38 1.07e-12 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg02132760 chr11:18416547 LDHA 0.47 6.6 0.34 1.7e-10 Response to antipsychotic treatment; CRC cis rs4819052 0.851 rs35560973 chr21:46662573 T/C cg02159808 chr21:46707872 POFUT2;LOC642852 0.46 6.08 0.32 3.34e-9 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs3736485 0.934 rs4775955 chr15:51873449 C/T cg08986416 chr15:51914746 DMXL2 0.45 6.47 0.34 3.47e-10 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs13315871 0.929 rs77825960 chr3:58318677 A/G cg20936604 chr3:58311152 NA -0.75 -7.7 -0.39 1.63e-13 Cholesterol, total; CRC trans rs2303319 0.504 rs62187613 chr2:162434474 T/C cg18122310 chr12:50236657 BCDIN3D -0.74 -6.05 -0.32 3.89e-9 Cognitive function; CRC cis rs7107174 0.688 rs2063724 chr11:78133077 T/C cg12700464 chr11:78128424 GAB2 -0.47 -5.63 -0.3 3.87e-8 Testicular germ cell tumor; CRC cis rs992157 0.735 rs10932765 chr2:219099484 T/C cg04731861 chr2:219085781 ARPC2 -0.32 -6.79 -0.35 5.3e-11 Colorectal cancer; CRC cis rs9858542 0.953 rs6779524 chr3:49450449 C/T cg07274523 chr3:49395745 GPX1 0.45 6.11 0.32 2.89e-9 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs796364 0.806 rs203769 chr2:200900866 C/T cg23649088 chr2:200775458 C2orf69 -0.59 -5.89 -0.31 9.59e-9 Schizophrenia; CRC cis rs7224685 0.501 rs7222628 chr17:3890429 A/G cg11204139 chr17:3907470 NA 0.82 16.22 0.67 7.11e-44 Type 2 diabetes; CRC cis rs6762 0.719 rs28620453 chr11:836971 G/C cg11173246 chr11:841376 TSPAN4;POLR2L -0.34 -5.77 -0.3 1.87e-8 Mean platelet volume; CRC cis rs611744 0.608 rs612744 chr8:109245991 G/A cg18478394 chr8:109455254 TTC35 0.38 5.8 0.3 1.53e-8 Dupuytren's disease; CRC cis rs7666738 0.830 rs6819177 chr4:99040907 T/C cg17366294 chr4:99064904 C4orf37 0.44 7.5 0.38 6.02e-13 Colonoscopy-negative controls vs population controls; CRC cis rs41271951 0.512 rs12070256 chr1:151070090 C/T cg11822372 chr1:151115635 SEMA6C -0.71 -5.72 -0.3 2.34e-8 Blood protein levels; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg02679291 chr19:48248902 GLTSCR2 0.4 6.14 0.32 2.43e-9 Liver disease severity in Alagille syndrome; CRC cis rs780096 0.546 rs715325 chr2:27725572 C/A cg21248554 chr2:27665150 KRTCAP3 -0.31 -7.14 -0.37 5.85e-12 Total body bone mineral density; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg06157335 chr1:53164003 C1orf163 0.5 6.95 0.36 1.98e-11 Response to antipsychotic treatment; CRC cis rs10979 1.000 rs1416206 chr6:143889385 T/C cg25407410 chr6:143891975 LOC285740 -0.82 -13.4 -0.59 5.5e-33 Hypospadias; CRC cis rs800160 0.777 rs11022289 chr11:2345417 T/G cg09785033 chr11:2336066 TSPAN32 -0.48 -5.74 -0.3 2.13e-8 Bacteremia; CRC cis rs11212617 0.905 rs1893813 chr11:108054604 A/G cg14761454 chr11:108092087 ATM;NPAT 0.39 5.69 0.3 2.86e-8 Response to metformin in type 2 diabetes (glycemic); CRC cis rs644799 1.000 rs500054 chr11:95593806 G/A cg25622487 chr11:95524042 FAM76B;CEP57 0.78 12.0 0.55 9.05e-28 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs4604732 0.631 rs80319072 chr1:247626835 G/A cg12754571 chr1:247694271 LOC148824;OR2C3 0.41 5.78 0.3 1.74e-8 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CRC cis rs4664293 0.647 rs1425039 chr2:160428123 A/C cg08347373 chr2:160653686 CD302 -0.38 -6.42 -0.33 4.72e-10 Monocyte percentage of white cells; CRC cis rs9783347 1.000 rs12286683 chr11:18348662 G/T cg15585147 chr11:18324498 HPS5 0.45 6.34 0.33 7.44e-10 Pancreatic cancer; CRC cis rs644799 0.710 rs1852535 chr11:95501241 A/G cg25622487 chr11:95524042 FAM76B;CEP57 0.79 13.03 0.58 1.44e-31 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs7811142 0.562 rs7786844 chr7:99934008 T/G cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.82 10.83 0.51 1.45e-23 Platelet count; CRC cis rs6701037 1.000 rs1057305 chr1:175126223 T/A cg00321850 chr1:175162397 KIAA0040 -0.39 -6.19 -0.32 1.82e-9 Alcohol dependence; CRC cis rs950027 0.596 rs2467865 chr15:45638307 T/C cg21132104 chr15:45694354 SPATA5L1 0.42 6.18 0.32 1.89e-9 Response to fenofibrate (adiponectin levels); CRC cis rs58688157 0.705 rs11539530 chr11:609353 G/A cg07212818 chr11:638076 DRD4 -0.44 -5.66 -0.3 3.23e-8 Systemic lupus erythematosus; CRC cis rs2708977 0.965 rs13019986 chr2:97243058 C/T cg01950434 chr2:97203154 ARID5A 0.48 6.96 0.36 1.9e-11 Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes; CRC cis rs4862750 0.832 rs6836076 chr4:187899660 A/C cg11301795 chr4:187892539 NA -0.87 -20.32 -0.75 4.87e-60 Lobe attachment (rater-scored or self-reported); CRC cis rs9611565 0.694 rs9611591 chr22:41830212 G/A cg03806693 chr22:41940476 POLR3H 0.76 10.18 0.49 2.37e-21 Vitiligo; CRC cis rs4423214 1.000 rs11546509 chr11:71162785 A/G cg05163923 chr11:71159392 DHCR7 0.67 9.53 0.46 3.69e-19 Vitamin D levels; CRC trans rs2303319 0.504 rs62189042 chr2:162602320 G/T cg12500891 chr11:57225987 NA -0.65 -6.06 -0.32 3.77e-9 Cognitive function; CRC cis rs950027 0.787 rs1153845 chr15:45724729 C/T cg10760299 chr15:45669010 GATM -0.37 -5.83 -0.31 1.3e-8 Response to fenofibrate (adiponectin levels); CRC trans rs61931739 0.517 rs1486882 chr12:34025896 A/G cg26384229 chr12:38710491 ALG10B 0.52 6.65 0.34 1.22e-10 Morning vs. evening chronotype; CRC cis rs11676348 0.818 rs6436033 chr2:218983763 A/G cg00012203 chr2:219082015 ARPC2 -0.42 -6.2 -0.32 1.72e-9 Ulcerative colitis; CRC cis rs1550582 0.548 rs7828645 chr8:135497385 A/G cg17885191 chr8:135476712 NA -1.04 -13.29 -0.59 1.46e-32 Educational attainment; CRC cis rs7917772 0.505 rs61869211 chr10:104449836 A/G cg11453585 chr10:104263688 ACTR1A;SUFU 0.74 10.21 0.49 1.96e-21 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC cis rs6942756 0.806 rs2566877 chr7:128897317 G/A cg02491457 chr7:128862824 NA 0.66 9.19 0.45 4.59e-18 White matter hyperintensity burden; CRC cis rs2949837 0.528 rs10260816 chr7:46010100 C/G cg06713098 chr7:45960367 IGFBP3 -0.45 -6.84 -0.35 3.81e-11 Sitting height ratio; CRC cis rs490234 0.966 rs545900 chr9:128341278 C/T cg14078157 chr9:128172775 NA 0.38 6.34 0.33 7.65e-10 Mean arterial pressure; CRC cis rs10504229 0.906 rs17805439 chr8:58172400 T/C cg01721255 chr8:58191610 C8orf71 0.49 6.17 0.32 2e-9 Developmental language disorder (linguistic errors); CRC cis rs9435341 0.930 rs61798463 chr1:107565934 G/A cg14828511 chr1:107599125 PRMT6 0.48 6.6 0.34 1.61e-10 Facial morphology (factor 21, depth of nasal alae); CRC cis rs921968 0.612 rs573555 chr2:219348888 A/C cg02176678 chr2:219576539 TTLL4 0.49 8.05 0.41 1.58e-14 Mean corpuscular hemoglobin concentration; CRC cis rs28386778 0.897 rs8081454 chr17:61842646 A/G cg06601766 chr17:61851465 DDX42;CCDC47 0.45 6.1 0.32 3.06e-9 Prudent dietary pattern; CRC cis rs13382862 0.895 rs2289082 chr2:20881958 A/T cg14780466 chr2:20870812 GDF7 0.31 6.51 0.34 2.8e-10 Abdominal aortic aneurysm; CRC cis rs9303280 0.901 rs7216558 chr17:38070071 C/T cg00129232 chr17:37814104 STARD3 0.44 6.83 0.35 4.16e-11 Self-reported allergy; CRC cis rs7212590 0.529 rs60283440 chr17:57994248 T/C cg10252138 chr17:58120427 NA -0.61 -6.29 -0.33 1.02e-9 Granulocyte percentage of myeloid white cells;Monocyte count;Monocyte percentage of white cells; CRC cis rs10256972 0.577 rs4999286 chr7:1199506 C/G cg07092213 chr7:1199455 ZFAND2A -0.47 -6.82 -0.35 4.34e-11 Longevity;Endometriosis; CRC trans rs4762326 0.509 rs6538615 chr12:95587856 T/C cg16511708 chr18:23671264 SS18 0.42 5.98 0.31 5.85e-9 Endometriosis; CRC cis rs13108904 0.837 rs4591539 chr4:1279938 G/C cg05665937 chr4:1216051 CTBP1 0.4 5.78 0.3 1.74e-8 Obesity-related traits; CRC cis rs2976388 0.609 rs2585150 chr8:143792669 C/T cg22687807 chr8:143858763 LYNX1 0.51 9.17 0.45 5.35e-18 Urinary tract infection frequency; CRC cis rs1552244 1.000 rs35198334 chr3:10104553 G/C cg10729496 chr3:10149963 C3orf24 0.58 7.52 0.38 5.23e-13 Alzheimer's disease; CRC cis rs17767392 0.767 rs61989382 chr14:71983638 T/C cg13720639 chr14:72061746 SIPA1L1 -0.46 -6.15 -0.32 2.22e-9 Mitral valve prolapse; CRC cis rs1865760 0.929 rs1816546 chr6:25938252 C/T cg17691542 chr6:26056736 HIST1H1C 0.54 7.76 0.39 1.1e-13 Height; CRC cis rs10504229 1.000 rs56255635 chr8:58178264 T/C cg05313129 chr8:58192883 C8orf71 -0.47 -6.99 -0.36 1.49e-11 Developmental language disorder (linguistic errors); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg16803707 chr20:1099736 PSMF1 0.41 5.97 0.31 6.16e-9 Intelligence (multi-trait analysis); CRC cis rs7309 0.870 rs2358016 chr2:162007430 C/G cg13854012 chr2:162103682 NA 0.49 7.86 0.4 5.69e-14 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Educational attainment; CRC cis rs1881797 1.000 rs12081895 chr1:247686666 C/G cg21399703 chr1:247681439 NA 0.47 7.65 0.39 2.24e-13 Acute lymphoblastic leukemia (childhood); CRC cis rs1891275 0.515 rs10786010 chr10:93443773 G/A cg07889827 chr10:93443413 NA -0.39 -6.65 -0.34 1.2e-10 Intelligence (multi-trait analysis); CRC cis rs1801251 0.963 rs35395584 chr2:233573698 G/C cg25237894 chr2:233734115 C2orf82 0.53 8.57 0.43 4.11e-16 Coronary artery disease; CRC cis rs1552244 0.816 rs9847657 chr3:10173492 G/T cg16606324 chr3:10149918 C3orf24 0.56 7.96 0.4 2.73e-14 Alzheimer's disease; CRC trans rs3733585 0.579 rs4235356 chr4:10123106 G/C cg26043149 chr18:55253948 FECH -0.56 -7.91 -0.4 4.03e-14 Cleft plate (environmental tobacco smoke interaction); CRC cis rs6570726 0.791 rs10872577 chr6:145900560 G/T cg23711669 chr6:146136114 FBXO30 0.69 11.52 0.54 4.94e-26 Lobe attachment (rater-scored or self-reported); CRC cis rs6665290 0.901 rs12410103 chr1:227197408 T/C cg10327440 chr1:227177885 CDC42BPA -1.05 -23.43 -0.79 4.22e-72 Myeloid white cell count; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg05966498 chr5:10761293 DAP 0.47 7.73 0.39 1.3e-13 Liver disease severity in Alagille syndrome; CRC cis rs2635047 0.638 rs2571008 chr18:44649950 T/C cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.37 5.71 0.3 2.57e-8 Educational attainment; CRC cis rs1552244 0.882 rs13075842 chr3:10055813 A/C cg00166722 chr3:10149974 C3orf24 0.61 7.88 0.4 4.95e-14 Alzheimer's disease; CRC cis rs4713118 0.869 rs9283883 chr6:27715470 T/A cg06470822 chr6:28175283 NA 0.73 10.3 0.49 9.62e-22 Parkinson's disease; CRC cis rs2688608 0.592 rs10762559 chr10:75486453 G/C cg16540259 chr10:75572220 NDST2 0.38 6.0 0.31 5.25e-9 Inflammatory bowel disease; CRC cis rs11122272 0.735 rs2749708 chr1:231529610 G/A cg06096015 chr1:231504339 EGLN1 0.41 6.18 0.32 1.91e-9 Hemoglobin concentration; CRC cis rs939317 0.635 rs843371 chr3:183994536 A/G cg09405238 chr3:183994500 ECE2 0.51 6.19 0.32 1.74e-9 Menarche (age at onset); CRC cis rs9858542 0.903 rs11921590 chr3:49644193 T/C cg00383909 chr3:49044727 WDR6 0.49 6.05 0.32 3.86e-9 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg09242721 chr3:3168535 TRNT1 -0.39 -6.34 -0.33 7.53e-10 Myopia (pathological); CRC cis rs3820928 1.000 rs7592387 chr2:227777095 A/G cg11843606 chr2:227700838 RHBDD1 -0.41 -5.98 -0.31 5.91e-9 Pulmonary function; CRC cis rs8062405 0.755 rs4788078 chr16:28559981 G/A cg16576597 chr16:28551801 NUPR1 0.56 8.26 0.41 3.67e-15 Cognitive ability (multi-trait analysis);Cognitive ability; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg23633635 chr17:7297619 PLSCR3 0.37 5.98 0.31 5.8e-9 Liver disease severity in Alagille syndrome; CRC trans rs66887589 0.967 rs56173225 chr4:120509972 G/A cg25214090 chr10:38739885 LOC399744 -0.41 -6.38 -0.33 6e-10 Diastolic blood pressure; CRC cis rs919433 0.963 rs4850429 chr2:198178409 A/G cg20885578 chr2:198174922 NA 0.41 6.73 0.35 7.63e-11 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC cis rs875971 0.660 rs10281080 chr7:66042441 T/C cg00343986 chr7:65444356 GUSB -0.5 -7.51 -0.38 5.55e-13 Aortic root size; CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg04686114 chr12:57081832 PTGES3 0.42 6.58 0.34 1.81e-10 Obesity-related traits; CRC cis rs12024301 0.557 rs58620414 chr1:183621957 G/A cg11505048 chr1:183622726 RGL1;APOBEC4 0.81 7.0 0.36 1.42e-11 Peripheral arterial disease (traffic-related air pollution interaction); CRC trans rs6788895 0.661 rs16862837 chr3:150469858 A/C cg09676794 chr13:100310162 CLYBL 0.61 6.03 0.32 4.42e-9 Breast cancer; CRC cis rs514406 0.698 rs522259 chr1:53365481 A/G cg08859206 chr1:53392774 SCP2 -0.6 -9.27 -0.46 2.46e-18 Monocyte count; CRC cis rs2032447 0.613 rs6456708 chr6:26032847 G/C cg04800585 chr6:26043546 HIST1H2BB 0.39 6.11 0.32 2.89e-9 Intelligence (multi-trait analysis); CRC cis rs4713118 0.669 rs200997 chr6:27811815 G/A cg06470822 chr6:28175283 NA 0.73 10.51 0.5 1.74e-22 Parkinson's disease; CRC cis rs4713118 0.568 rs9468213 chr6:27706180 G/A cg02683197 chr6:28174875 NA 0.62 8.75 0.43 1.11e-16 Parkinson's disease; CRC cis rs951366 0.585 rs72750964 chr1:205675240 C/T cg14893161 chr1:205819251 PM20D1 0.83 12.64 0.57 3.88e-30 Menarche (age at onset); CRC trans rs10506458 0.915 rs17738485 chr12:63394932 T/C cg03429785 chr15:59498649 MYO1E;LDHAL6B -1.45 -21.36 -0.76 3.94e-64 Hemostatic factors and hematological phenotypes; CRC cis rs2797160 1.000 rs1578794 chr6:126015469 T/C cg05901451 chr6:126070800 HEY2 0.39 6.06 0.32 3.66e-9 Endometrial cancer; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg27006547 chr11:62606509 WDR74 0.5 6.99 0.36 1.56e-11 Thyroid stimulating hormone; CRC trans rs9341835 0.584 rs1741801 chr6:64145375 T/C cg13657004 chr13:50234944 EBPL -0.38 -6.45 -0.34 4.07e-10 Schizophrenia; CRC cis rs889398 0.771 rs1566454 chr16:69900083 C/T cg00738113 chr16:70207722 CLEC18C -0.37 -6.3 -0.33 9.79e-10 Body mass index; CRC cis rs4237845 0.591 rs4760344 chr12:58320783 A/T cg02175503 chr12:58329896 NA 0.69 9.65 0.47 1.44e-19 Intelligence (multi-trait analysis); CRC cis rs1878931 0.582 rs40633 chr16:3425325 A/G cg26668626 chr16:3451006 ZNF174;ZNF434 -0.56 -6.89 -0.36 2.82e-11 Body mass index (adult); CRC cis rs600806 0.888 rs461200 chr1:109855404 G/A cg23032129 chr1:109941072 SORT1 -0.27 -5.86 -0.31 1.14e-8 Intelligence (multi-trait analysis); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg23019037 chr1:224622598 WDR26 0.5 7.11 0.36 7.39e-12 Response to antipsychotic treatment; CRC cis rs6951245 1.000 rs79765398 chr7:1073764 A/G cg20603222 chr7:1096387 C7orf50;GPR146 -0.69 -8.13 -0.41 8.62e-15 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs7647973 0.626 rs62260723 chr3:49872124 T/C cg13072238 chr3:49761600 GMPPB 0.5 5.84 0.31 1.25e-8 Menarche (age at onset); CRC cis rs17270561 0.609 rs4712957 chr6:25719814 C/T cg16482183 chr6:26056742 HIST1H1C 0.74 9.47 0.46 5.46e-19 Iron status biomarkers; CRC cis rs11148252 0.532 rs9536190 chr13:53181044 T/C cg02158880 chr13:53174818 NA 0.68 10.35 0.5 6.61e-22 Lewy body disease; CRC cis rs4728302 0.869 rs7779370 chr7:133595702 T/C cg03336402 chr7:133662267 EXOC4 -0.45 -6.51 -0.34 2.78e-10 Intelligence;Intelligence (multi-trait analysis); CRC cis rs765787 0.530 rs11636410 chr15:45535913 A/C cg24006582 chr15:45444508 DUOX1 0.58 8.54 0.43 4.99e-16 Uric acid levels; CRC cis rs763121 0.853 rs5750627 chr22:38982321 A/G cg06022373 chr22:39101656 GTPBP1 0.8 13.58 0.6 1.17e-33 Menopause (age at onset); CRC cis rs1997103 0.954 rs6593235 chr7:55410986 A/G cg17469321 chr7:55412551 NA 0.73 11.05 0.52 2.33e-24 QRS interval (sulfonylurea treatment interaction); CRC cis rs1799949 1.000 rs4793192 chr17:41204390 T/C cg23758822 chr17:41437982 NA 0.8 13.69 0.6 4.46e-34 Menopause (age at onset); CRC cis rs362272 0.505 rs60208975 chr4:3364530 A/G cg02993699 chr4:3415135 RGS12 -0.39 -6.5 -0.34 3.04e-10 Serum sulfate level; CRC cis rs5769707 0.605 rs9616702 chr22:50025938 A/G cg20744362 chr22:50050164 C22orf34 0.33 5.92 0.31 8.07e-9 Monocyte count;Monocyte percentage of white cells; CRC cis rs9733 0.596 rs2867300 chr1:150666990 C/G cg15448220 chr1:150897856 SETDB1 0.46 6.57 0.34 1.93e-10 Tonsillectomy; CRC cis rs13108904 0.901 rs12509700 chr4:1296321 A/G cg23123621 chr4:1343375 KIAA1530 0.35 6.48 0.34 3.4e-10 Obesity-related traits; CRC cis rs9457247 0.765 rs9457251 chr6:167426707 T/C cg07741184 chr6:167504864 NA 0.39 6.72 0.35 8.06e-11 Crohn's disease; CRC cis rs7107174 1.000 rs2512549 chr11:77940163 A/G cg02023728 chr11:77925099 USP35 -0.51 -8.65 -0.43 2.29e-16 Testicular germ cell tumor; CRC cis rs834811 0.505 rs7789711 chr7:135938979 C/T cg01726295 chr7:135938950 NA -0.54 -9.55 -0.47 3.1400000000000002e-19 Post-traumatic stress disorder; CRC cis rs4665809 1.000 rs6546736 chr2:26293878 C/T cg27170947 chr2:26402098 FAM59B 0.45 6.04 0.32 4.07e-9 Gut microbiome composition (summer); CRC cis rs7666738 0.716 rs11097615 chr4:99092773 T/C cg17366294 chr4:99064904 C4orf37 0.35 5.67 0.3 3.18e-8 Colonoscopy-negative controls vs population controls; CRC cis rs17711722 0.528 rs73138179 chr7:65294482 G/T cg18876405 chr7:65276391 NA 0.5 7.98 0.4 2.38e-14 Calcium levels; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg21344124 chr8:22857393 RHOBTB2 0.39 5.97 0.31 6.28e-9 Liver disease severity in Alagille syndrome; CRC cis rs10791097 0.694 rs2236711 chr11:130739284 G/A cg12179176 chr11:130786555 SNX19 0.76 12.84 0.58 7.22e-31 Autism spectrum disorder or schizophrenia;Schizophrenia; CRC cis rs635808 0.561 rs491700 chr6:167171838 A/G cg27626620 chr6:167171727 RPS6KA2 -0.37 -6.33 -0.33 7.97e-10 Dental caries; CRC cis rs34293785 0.565 rs59710023 chr1:66137193 T/C cg04111102 chr1:66153794 NA 0.35 6.02 0.31 4.67e-9 Neutrophil percentage of white cells;Granulocyte percentage of myeloid white cells;Sum neutrophil eosinophil counts;Monocyte percentage of white cells;Sum basophil neutrophil counts;Neutrophil count;White blood cell count; CRC cis rs7584330 0.780 rs2292884 chr2:238443226 A/G cg16989719 chr2:238392110 NA -0.41 -7.98 -0.4 2.46e-14 Prostate cancer; CRC cis rs13191362 0.810 rs28360533 chr6:162996742 A/G cg06582575 chr6:163149167 PACRG;PARK2 0.79 10.88 0.51 9.36e-24 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs6499255 0.951 rs8046314 chr16:69697922 T/A cg00738113 chr16:70207722 CLEC18C -0.38 -5.62 -0.3 4.13e-8 IgE levels; CRC cis rs2839186 0.558 rs2968 chr21:47608580 C/T cg12516959 chr21:47718080 NA 0.34 6.1 0.32 2.91e-9 Testicular germ cell tumor; CRC cis rs6732160 0.588 rs13390460 chr2:73371476 G/A cg01422370 chr2:73384389 NA 0.38 5.98 0.31 5.93e-9 Intelligence (multi-trait analysis); CRC cis rs7208859 0.623 rs11657391 chr17:29194287 G/A cg01831904 chr17:28903510 LRRC37B2 -0.55 -5.77 -0.3 1.88e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs11958404 0.932 rs6870115 chr5:157436960 T/C cg05962755 chr5:157440814 NA 1.01 12.88 0.58 5.12e-31 IgG glycosylation; CRC cis rs7208859 0.673 rs9895684 chr17:29242600 G/A cg01831904 chr17:28903510 LRRC37B2 -0.56 -5.82 -0.31 1.38e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs2979489 0.891 rs2915624 chr8:30381245 T/C cg26383811 chr8:30366931 RBPMS -0.7 -10.29 -0.49 1.01e-21 Mean corpuscular hemoglobin;Plateletcrit;Neutrophil count;Granulocyte count;Sum basophil neutrophil counts;Mean corpuscular volume;Myeloid white cell count;Sum neutrophil eosinophil counts; CRC cis rs7771547 0.519 rs12663882 chr6:36362441 G/T cg04289385 chr6:36355825 ETV7 -0.44 -5.62 -0.3 4.11e-8 Platelet distribution width; CRC cis rs1568889 1.000 rs12287732 chr11:28120845 A/G cg06544937 chr11:28130018 METT5D1;KIF18A 0.76 10.68 0.51 4.57e-23 Bipolar disorder; CRC cis rs66573146 1.000 rs56074877 chr4:6990374 C/T cg00086871 chr4:6988644 TBC1D14 0.95 7.98 0.4 2.46e-14 Granulocyte percentage of myeloid white cells; CRC cis rs172166 0.637 rs1233708 chr6:28173219 C/T cg15786705 chr6:28176104 NA 0.66 9.73 0.47 7.63e-20 Cardiac Troponin-T levels; CRC cis rs1348850 0.632 rs13008857 chr2:178514468 G/A cg22681709 chr2:178499509 PDE11A -0.5 -9.36 -0.46 1.27e-18 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs4665809 0.878 rs892448 chr2:26366205 A/G cg22920501 chr2:26401640 FAM59B -0.53 -6.87 -0.35 3.18e-11 Gut microbiome composition (summer); CRC cis rs372883 0.530 rs11088110 chr21:30543373 G/A cg24692254 chr21:30365293 RNF160 -0.38 -5.61 -0.3 4.3e-8 Pancreatic cancer; CRC cis rs11122272 0.705 rs1416914 chr1:231533196 C/T cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.59 -8.95 -0.44 2.58e-17 Hemoglobin concentration; CRC cis rs3857067 0.506 rs282450 chr4:95139598 G/C cg11021082 chr4:95130006 SMARCAD1 -0.6 -9.52 -0.46 3.84e-19 QT interval; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg10757027 chr7:150783788 AGAP3 0.4 7.35 0.38 1.63e-12 Liver disease severity in Alagille syndrome; CRC cis rs7923609 0.967 rs10761762 chr10:65184717 T/C cg08743896 chr10:65200160 JMJD1C -0.42 -6.12 -0.32 2.62e-9 Educational attainment;Liver enzyme levels (alkaline phosphatase); CRC cis rs2384207 0.818 rs7962969 chr12:113674461 C/T cg22376712 chr12:113623594 C12orf52;DDX54 0.48 5.9 0.31 8.94e-9 Response to fenofibrate (adiponectin levels); CRC cis rs9486719 1.000 rs10872018 chr6:97026429 G/A cg06623918 chr6:96969491 KIAA0776 -0.82 -9.53 -0.47 3.58e-19 Migraine;Coronary artery disease; CRC cis rs6912958 0.712 rs2754260 chr6:88397666 T/C cg12350822 chr6:88032061 C6orf162;GJB7 -0.32 -6.12 -0.32 2.68e-9 Monocyte percentage of white cells; CRC trans rs16846053 0.681 rs62187569 chr2:162373517 A/G cg27113153 chr11:123612418 ZNF202 -0.72 -6.17 -0.32 1.96e-9 Blood osmolality (transformed sodium); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg11522767 chr6:157342961 ARID1B 0.49 7.23 0.37 3.44e-12 Response to antipsychotic treatment; CRC cis rs3096299 0.685 rs12935112 chr16:89542858 C/T cg01788221 chr16:89496183 ANKRD11 0.39 5.93 0.31 7.77e-9 Multiple myeloma (IgH translocation); CRC cis rs62064224 0.714 rs8074594 chr17:30632998 G/A cg25809561 chr17:30822961 MYO1D 0.52 9.42 0.46 8.1e-19 Schizophrenia; CRC cis rs7615952 0.599 rs2270986 chr3:125701099 T/C cg15145296 chr3:125709740 NA -0.57 -6.72 -0.35 7.95e-11 Blood pressure (smoking interaction); CRC cis rs636291 0.517 rs670666 chr1:10549380 C/T cg17425144 chr1:10567563 PEX14 -0.52 -11.8 -0.55 5.08e-27 Prostate cancer; CRC cis rs6504622 0.755 rs11079750 chr17:45149515 T/C cg16759221 chr17:45003025 GOSR2 0.44 6.74 0.35 7.12e-11 Orofacial clefts; CRC cis rs10078 0.515 rs2672739 chr5:443447 A/C cg24955955 chr5:415729 AHRR 0.56 5.66 0.3 3.38e-8 Fat distribution (HIV); CRC cis rs4862750 0.624 rs34414639 chr4:187873417 C/A cg07414643 chr4:187882934 NA 0.36 6.24 0.33 1.33e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs11608355 0.618 rs11066368 chr12:109790342 C/T cg19025524 chr12:109796872 NA -0.62 -10.36 -0.5 6.05e-22 Neuroticism; CRC trans rs11098499 0.532 rs4504231 chr4:120586891 G/A cg25214090 chr10:38739885 LOC399744 0.52 7.92 0.4 3.7e-14 Corneal astigmatism; CRC cis rs11690935 0.632 rs12052246 chr2:172895606 G/T cg13550731 chr2:172543902 DYNC1I2 0.62 9.14 0.45 6.61e-18 Schizophrenia; CRC cis rs3091242 0.935 rs3093632 chr1:25684012 C/T cg27572855 chr1:25598939 RHD 0.37 6.71 0.35 8.38e-11 Erythrocyte sedimentation rate; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg01945793 chr7:10979586 NDUFA4 0.4 6.36 0.33 6.74e-10 Liver disease severity in Alagille syndrome; CRC cis rs9649213 0.593 rs1132971 chr7:97921533 A/G cg21770322 chr7:97807741 LMTK2 0.54 9.03 0.45 1.52e-17 Prostate cancer (SNP x SNP interaction); CRC cis rs9287719 0.901 rs4555317 chr2:10744247 A/G cg00105475 chr2:10696890 NA 0.45 7.3 0.37 2.2e-12 Prostate cancer; CRC trans rs1814175 0.616 rs10769644 chr11:49987676 C/A cg15704280 chr7:45808275 SEPT13 -0.94 -16.88 -0.68 1.75e-46 Height; CRC cis rs72781680 0.756 rs2712059 chr2:24020539 T/C cg08917208 chr2:24149416 ATAD2B 0.53 6.36 0.33 6.58e-10 Lymphocyte counts; CRC cis rs9910055 0.659 rs7212573 chr17:42254281 A/G cg16434002 chr17:42200994 HDAC5 -0.52 -7.44 -0.38 8.68e-13 Total body bone mineral density; CRC cis rs7312933 1.000 rs12372623 chr12:42531666 G/A cg17420585 chr12:42539391 GXYLT1 -0.41 -5.98 -0.31 5.73e-9 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CRC cis rs3733346 0.505 rs11734449 chr4:921733 C/A cg15105011 chr4:940614 TMEM175 0.55 8.33 0.42 2.24e-15 Sjögren's syndrome; CRC cis rs2898681 0.528 rs73814883 chr4:53728054 G/C cg26260408 chr4:53727979 RASL11B 0.53 6.29 0.33 1.04e-9 Optic nerve measurement (cup area); CRC cis rs6580649 0.771 rs1034762 chr12:48389643 G/T cg05342945 chr12:48394962 COL2A1 0.44 6.18 0.32 1.9e-9 Lung cancer; CRC cis rs798554 0.607 rs1182151 chr7:2909225 C/G cg19717773 chr7:2847554 GNA12 -0.41 -5.72 -0.3 2.4e-8 Height; CRC cis rs11764590 0.671 rs3800872 chr7:2110272 C/G cg21155852 chr7:2048760 MAD1L1 -0.46 -6.45 -0.34 3.99e-10 Neuroticism; CRC cis rs514406 0.644 rs1855127 chr1:53199594 A/G cg25767906 chr1:53392781 SCP2 0.36 5.82 0.31 1.41e-8 Monocyte count; CRC cis rs10791097 0.694 rs7926167 chr11:130745045 T/C cg12179176 chr11:130786555 SNX19 0.75 12.66 0.57 3.46e-30 Autism spectrum disorder or schizophrenia;Schizophrenia; CRC cis rs4474465 0.646 rs6592794 chr11:78275743 A/G cg27205649 chr11:78285834 NARS2 0.5 6.45 0.33 4.05e-10 Alzheimer's disease (survival time); CRC trans rs9929218 0.954 rs34530130 chr16:68827620 C/T cg04657470 chr2:198365150 HSPE1;HSPD1 -0.76 -10.78 -0.51 2.07e-23 Colorectal cancer; CRC cis rs6541297 0.775 rs4846910 chr1:230291441 C/A cg20703242 chr1:230279135 GALNT2 0.49 6.79 0.35 5.25e-11 Coronary artery disease; CRC cis rs763121 0.853 rs5750633 chr22:38993467 A/G cg06022373 chr22:39101656 GTPBP1 0.8 13.35 0.59 8.54e-33 Menopause (age at onset); CRC cis rs11098699 0.750 rs1500122 chr4:124220060 A/C cg09941581 chr4:124220074 SPATA5 0.43 6.36 0.33 6.83e-10 Mosquito bite size; CRC cis rs798554 0.836 rs798490 chr7:2801542 C/T cg19346786 chr7:2764209 NA -0.43 -7.44 -0.38 8.69e-13 Height; CRC trans rs916888 0.821 rs199506 chr17:44859031 A/G cg23590916 chr17:43697445 MGC57346 -0.56 -6.07 -0.32 3.56e-9 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs860295 0.676 rs11264374 chr1:155421512 A/C cg02153340 chr1:155202674 NA -0.56 -6.67 -0.34 1.11e-10 Body mass index; CRC cis rs3018066 0.748 rs7677248 chr4:106960497 C/T cg01869342 chr4:106983673 TBCK -0.45 -6.85 -0.35 3.75e-11 Cancer; CRC cis rs9811920 0.609 rs9872871 chr3:99658702 C/G cg07805332 chr3:99536008 MIR548G;C3orf26 0.51 7.64 0.39 2.42e-13 Axial length; CRC cis rs12926788 0.689 rs1862450 chr16:24856775 A/G cg02428538 chr16:24856791 SLC5A11 0.73 8.62 0.43 2.93e-16 Ejection fraction in Tripanosoma cruzi seropositivity; CRC cis rs9906695 0.846 rs4795904 chr17:32618981 C/T cg12698626 chr17:32581466 CCL2 0.47 6.33 0.33 7.82e-10 Monocyte percentage of white cells; CRC cis rs875971 0.660 rs3764903 chr7:66098482 G/A cg11764359 chr7:65958608 NA -0.54 -8.38 -0.42 1.53e-15 Aortic root size; CRC cis rs9391253 0.571 rs1475120 chr6:105389953 G/A cg02098413 chr6:105308735 HACE1 0.31 5.61 0.3 4.24e-8 Height;Age at voice drop;Puberty onset (breast development); CRC cis rs9549260 0.816 rs7328594 chr13:41253764 T/C cg21288729 chr13:41239152 FOXO1 0.48 7.39 0.38 1.25e-12 Red blood cell count; CRC trans rs6951245 1.000 rs11767527 chr7:1097394 T/C cg13565492 chr6:43139072 SRF -0.72 -7.44 -0.38 8.63e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs6461049 0.646 rs3778970 chr7:2143208 C/A cg22963979 chr7:1858916 MAD1L1 -0.44 -6.36 -0.33 6.84e-10 Schizophrenia; CRC trans rs9585327 0.584 rs4772260 chr13:100645723 A/G cg10243681 chr15:73925924 NPTN 0.37 5.99 0.31 5.55e-9 Myopia; CRC cis rs1448094 0.512 rs7313035 chr12:86250100 C/G cg25456477 chr12:86230367 RASSF9 0.34 5.99 0.31 5.54e-9 Major depressive disorder; CRC trans rs10842750 1.000 rs10842750 chr12:26690565 G/T cg15135914 chr11:65430544 RELA 0.52 6.48 0.34 3.31e-10 Kashin-Beck disease; CRC cis rs13631 0.728 rs7466635 chr9:139980417 T/C cg03717367 chr9:139980219 LOC100289341;MAN1B1 -0.32 -6.03 -0.32 4.39e-9 Cerebrospinal fluid biomarker levels; CRC trans rs875971 0.660 rs2191268 chr7:66110224 C/T cg23029363 chr5:137803326 EGR1 0.39 6.05 0.32 3.85e-9 Aortic root size; CRC cis rs262150 0.659 rs2527236 chr7:158796644 C/T cg07130601 chr7:158766826 NA 0.42 5.99 0.31 5.43e-9 Facial morphology (factor 20); CRC cis rs11945232 1.000 rs4314250 chr4:88340969 A/G cg23841344 chr4:88312519 HSD17B11 0.53 6.91 0.36 2.54e-11 Intelligence (multi-trait analysis); CRC cis rs8060686 0.858 rs7198357 chr16:67884619 A/G cg07125278 chr16:67683757 RLTPR 0.44 5.9 0.31 8.8e-9 HDL cholesterol;Metabolic syndrome; CRC cis rs4474465 0.688 rs7929656 chr11:78276416 T/C cg27205649 chr11:78285834 NARS2 0.53 6.93 0.36 2.18e-11 Alzheimer's disease (survival time); CRC cis rs10752881 1.000 rs4420053 chr1:182976133 A/C ch.1.3577855R chr1:183094577 LAMC1 0.87 15.17 0.64 8.98e-40 Colorectal cancer; CRC cis rs5756931 0.503 rs2076112 chr22:38538822 A/G cg25457927 chr22:38595422 NA -0.31 -6.38 -0.33 6.07e-10 Triglycerides; CRC trans rs7580658 0.614 rs7585198 chr2:127962635 C/T cg10813610 chr7:150783881 AGAP3 -0.48 -6.67 -0.35 1.09e-10 Protein C levels; CRC cis rs9900062 1.000 rs9900062 chr17:62739574 G/A cg02598441 chr17:62777298 LOC146880 -0.58 -6.85 -0.35 3.6e-11 QT interval; CRC cis rs896854 0.654 rs10429443 chr8:95971164 A/G cg13393036 chr8:95962371 TP53INP1 -0.54 -9.26 -0.45 2.63e-18 Type 2 diabetes; CRC cis rs1949733 0.656 rs2631762 chr4:8423122 A/T cg11789530 chr4:8429930 ACOX3 0.74 10.87 0.51 1.05e-23 Response to antineoplastic agents; CRC cis rs853679 0.546 rs200990 chr6:27815823 T/G cg08798685 chr6:27730294 NA -0.63 -6.15 -0.32 2.23e-9 Depression; CRC cis rs12541335 0.639 rs7834182 chr8:22163112 G/A cg14487702 chr8:22132665 PIWIL2 0.37 5.65 0.3 3.54e-8 Hypertriglyceridemia; CRC cis rs7786808 0.552 rs35809824 chr7:158185067 C/T cg09998033 chr7:158218633 PTPRN2 -0.54 -7.3 -0.37 2.11e-12 Obesity-related traits; CRC cis rs7635838 0.617 rs184700 chr3:11293061 A/G cg00170343 chr3:11313890 ATG7 0.58 8.89 0.44 4.16e-17 HDL cholesterol; CRC cis rs7487075 0.619 rs4076247 chr12:46833450 A/C cg22049899 chr12:47219821 SLC38A4 0.31 5.74 0.3 2.12e-8 Itch intensity from mosquito bite; CRC cis rs17270561 0.585 rs9393663 chr6:25741033 A/T cg17691542 chr6:26056736 HIST1H1C 0.72 9.24 0.45 3.07e-18 Iron status biomarkers; CRC cis rs5758659 0.652 rs133349 chr22:42428727 A/T cg04733989 chr22:42467013 NAGA 0.41 5.81 0.3 1.51e-8 Cognitive function; CRC cis rs7647973 0.580 rs2334958 chr3:49252364 C/T cg03060546 chr3:49711283 APEH 0.47 7.06 0.36 1.01e-11 Menarche (age at onset); CRC cis rs2576037 0.583 rs644731 chr18:44426877 C/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.62 10.97 0.52 4.44e-24 Personality dimensions; CRC cis rs6762 0.719 rs28620453 chr11:836971 G/C cg15787769 chr11:842744 TSPAN4;POLR2L -0.47 -6.66 -0.34 1.16e-10 Mean platelet volume; CRC cis rs4713118 0.869 rs2056925 chr6:27690905 A/G cg15786705 chr6:28176104 NA 0.52 7.23 0.37 3.44e-12 Parkinson's disease; CRC cis rs2549003 1.000 rs2549002 chr5:131829578 C/A cg02551604 chr5:131831745 NA 0.59 8.99 0.44 1.93e-17 Asthma (sex interaction); CRC cis rs9443645 0.901 rs9448596 chr6:79629429 T/C cg11833968 chr6:79620685 NA -0.35 -6.05 -0.32 3.91e-9 Intelligence (multi-trait analysis); CRC cis rs1105228 0.759 rs581335 chr6:165709371 C/T cg20535254 chr6:165714960 C6orf118 -0.3 -6.27 -0.33 1.13e-9 Number of pregnancies;Number of children; CRC cis rs7107174 1.000 rs2512532 chr11:77968641 T/C cg02023728 chr11:77925099 USP35 0.52 7.99 0.4 2.37e-14 Testicular germ cell tumor; CRC cis rs4588572 0.537 rs7702000 chr5:77730556 A/G cg11547950 chr5:77652471 NA -0.5 -7.07 -0.36 9.09e-12 Triglycerides; CRC cis rs870825 0.587 rs58332461 chr4:185639742 G/A cg04058563 chr4:185651563 MLF1IP 0.73 9.41 0.46 9.01e-19 Blood protein levels; CRC cis rs7587476 0.784 rs36086595 chr2:215680293 A/G cg04004882 chr2:215674386 BARD1 0.67 9.41 0.46 8.78e-19 Neuroblastoma; CRC cis rs4319547 0.774 rs7954006 chr12:123131824 A/C cg05707623 chr12:122985044 ZCCHC8 0.58 7.51 0.38 5.57e-13 Body mass index; CRC cis rs79349575 0.783 rs2088139 chr17:47000110 C/T cg22482690 chr17:47019901 SNF8 0.48 8.07 0.41 1.33e-14 Type 2 diabetes; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg27171280 chr4:89205853 PPM1K -0.39 -6.0 -0.31 5.27e-9 Myopia (pathological); CRC cis rs6088580 0.634 rs6087580 chr20:32992592 A/G cg24642439 chr20:33292090 TP53INP2 -0.39 -6.48 -0.34 3.33e-10 Glomerular filtration rate (creatinine); CRC cis rs4713118 0.621 rs9295756 chr6:28033396 G/T cg21251018 chr6:28226885 NKAPL 0.47 6.37 0.33 6.33e-10 Parkinson's disease; CRC cis rs7625357 1.000 rs7653417 chr3:169350023 G/A cg04414509 chr3:169351419 MECOM 0.63 8.9 0.44 3.88e-17 Childhood and early adolescence aggressive behavior; CRC cis rs8180040 0.676 rs7636252 chr3:47013542 T/G cg27129171 chr3:47204927 SETD2 0.65 10.3 0.49 9.6e-22 Colorectal cancer; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg09219451 chr7:27224123 HOXA11AS;HOXA11 0.47 6.59 0.34 1.76e-10 Anxiety disorder; CRC cis rs9926296 0.528 rs4785721 chr16:89839997 G/A cg27121462 chr16:89883253 FANCA 0.58 9.17 0.45 5.3e-18 Vitiligo; CRC cis rs992157 0.735 rs13393821 chr2:219076742 C/G cg00012203 chr2:219082015 ARPC2 0.61 10.38 0.5 5.17e-22 Colorectal cancer; CRC cis rs10504229 0.679 rs11783965 chr8:58130510 T/G cg04204079 chr8:58130323 NA -0.44 -5.69 -0.3 2.78e-8 Developmental language disorder (linguistic errors); CRC cis rs9467711 0.606 rs68072215 chr6:26377927 T/C cg16898833 chr6:26189333 HIST1H4D 0.79 6.68 0.35 1.01e-10 Autism spectrum disorder or schizophrenia; CRC cis rs7666738 0.830 rs7686456 chr4:99019695 T/C cg05340658 chr4:99064831 C4orf37 0.61 9.51 0.46 4.05e-19 Colonoscopy-negative controls vs population controls; CRC cis rs524281 0.814 rs10896098 chr11:65968416 G/A cg14036092 chr11:66035641 RAB1B -0.48 -5.77 -0.3 1.79e-8 Electroencephalogram traits; CRC cis rs3772130 0.926 rs66653099 chr3:121393089 T/G cg20356878 chr3:121714668 ILDR1 0.49 7.33 0.37 1.82e-12 Cognitive performance; CRC cis rs7615952 0.546 rs2979307 chr3:125309574 C/T cg11143507 chr3:125485238 NA 0.51 5.67 0.3 3.17e-8 Blood pressure (smoking interaction); CRC cis rs2180341 1.000 rs9401950 chr6:127655485 C/T cg24812749 chr6:127587940 RNF146 0.95 13.72 0.6 3.35e-34 Breast cancer; CRC cis rs2180341 0.924 rs6930849 chr6:127630963 A/T cg27446573 chr6:127587934 RNF146 0.99 14.65 0.63 8.94e-38 Breast cancer; CRC cis rs798554 0.757 rs1183085 chr7:2875570 G/A cg19717773 chr7:2847554 GNA12 -0.48 -6.94 -0.36 2.09e-11 Height; CRC cis rs7666738 0.830 rs10025174 chr4:98914172 A/G cg05340658 chr4:99064831 C4orf37 0.57 8.65 0.43 2.27e-16 Colonoscopy-negative controls vs population controls; CRC cis rs7539624 0.588 rs10916598 chr1:223895559 G/A cg10100437 chr1:223903862 CAPN2 0.42 5.7 0.3 2.67e-8 Schizophrenia; CRC cis rs72634258 0.554 rs35307738 chr1:7919839 C/G cg26816564 chr1:7831052 VAMP3 0.75 8.73 0.43 1.31e-16 Inflammatory bowel disease; CRC cis rs3087591 1.000 rs9902427 chr17:29625430 G/A cg24425628 chr17:29625626 OMG;NF1 -0.84 -15.97 -0.66 6.48e-43 Hip circumference; CRC cis rs7786808 0.649 rs1377374 chr7:158215647 G/T cg17401720 chr7:158221031 PTPRN2 -0.4 -6.8 -0.35 4.94e-11 Obesity-related traits; CRC cis rs4722166 0.630 rs1829927 chr7:22779918 G/A cg05472934 chr7:22766657 IL6 0.76 12.37 0.56 4.12e-29 Lung cancer; CRC cis rs1215050 0.791 rs1605259 chr4:98799732 T/C cg05340658 chr4:99064831 C4orf37 0.47 6.96 0.36 1.84e-11 Waist-to-hip ratio adjusted for body mass index; CRC cis rs28386778 0.897 rs1043127 chr17:61791210 T/G cg06873352 chr17:61820015 STRADA 0.79 14.66 0.63 8.12e-38 Prudent dietary pattern; CRC cis rs9323205 0.954 rs4258524 chr14:51638739 A/T cg23942311 chr14:51606299 NA -0.58 -8.07 -0.41 1.31e-14 Cancer; CRC cis rs4964805 0.641 rs10861094 chr12:104159716 C/A cg02344784 chr12:104178138 NT5DC3 0.49 7.66 0.39 2.17e-13 Attention deficit hyperactivity disorder; CRC cis rs9914988 0.943 rs2242345 chr17:27185827 C/T cg07195577 chr17:27052828 TLCD1 -0.41 -5.91 -0.31 8.66e-9 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs8077889 0.917 rs72836547 chr17:41902799 G/T cg26893861 chr17:41843967 DUSP3 0.95 12.31 0.56 6.63e-29 Triglycerides; CRC cis rs6665290 0.669 rs3768419 chr1:227173477 C/G cg10327440 chr1:227177885 CDC42BPA -0.98 -20.34 -0.75 3.97e-60 Myeloid white cell count; CRC cis rs8077889 0.917 rs6503479 chr17:41917003 A/G cg26893861 chr17:41843967 DUSP3 0.9 12.86 0.58 6.25e-31 Triglycerides; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg20471045 chr19:49568214 NTF4 0.42 6.89 0.36 2.88e-11 Liver disease severity in Alagille syndrome; CRC trans rs6703335 0.870 rs10803142 chr1:243598234 A/G cg01070657 chr2:207988837 KLF7 0.43 6.88 0.35 2.94e-11 Schizophrenia;Schizophrenia, schizoaffective disorder or bipolar disorder; CRC cis rs3749237 0.595 rs3924462 chr3:49524236 T/G cg07636037 chr3:49044803 WDR6 0.56 8.03 0.4 1.72e-14 Resting heart rate; CRC cis rs67311347 1.000 rs12108041 chr3:40487535 C/T cg24209194 chr3:40518798 ZNF619 0.41 5.93 0.31 7.71e-9 Renal cell carcinoma; CRC trans rs875971 0.660 rs2191268 chr7:66110224 C/T cg07936541 chr2:98206095 ANKRD36B -0.42 -6.71 -0.35 8.5e-11 Aortic root size; CRC cis rs736801 0.521 rs2070729 chr5:131819921 G/T cg21138405 chr5:131827807 IRF1 0.44 8.38 0.42 1.53e-15 Breast cancer;Mosquito bite size; CRC cis rs938554 0.736 rs4697699 chr4:9945722 T/C cg00071950 chr4:10020882 SLC2A9 -0.41 -5.69 -0.3 2.74e-8 Blood metabolite levels; CRC cis rs9814567 1.000 rs6800862 chr3:134228628 A/G cg06109529 chr3:134205091 CEP63;ANAPC13 -0.8 -11.94 -0.55 1.47e-27 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs7666738 0.830 rs10012167 chr4:99048579 T/C cg17366294 chr4:99064904 C4orf37 0.45 7.75 0.39 1.16e-13 Colonoscopy-negative controls vs population controls; CRC trans rs1814175 0.669 rs12364577 chr11:49707361 A/C cg21153622 chr11:89784906 NA -0.43 -7.1 -0.36 7.73e-12 Height; CRC cis rs11719291 0.833 rs11709246 chr3:48859498 G/A cg00383909 chr3:49044727 WDR6 1.31 12.52 0.57 1.13e-29 Cognitive function; CRC cis rs6662572 0.578 rs6662307 chr1:46287287 G/T cg03123370 chr1:45965343 CCDC163P;MMACHC 0.46 5.87 0.31 1.04e-8 Blood protein levels; CRC cis rs1580019 0.537 rs7804609 chr7:32558094 A/C cg07520158 chr7:32535189 LSM5;AVL9 0.53 7.78 0.39 9.42e-14 Cognitive ability; CRC cis rs9311474 0.607 rs34005367 chr3:52558904 A/T cg18591801 chr3:52553433 STAB1 -0.3 -5.6 -0.3 4.5e-8 Electroencephalogram traits; CRC cis rs10504229 0.683 rs10504225 chr8:58145121 A/T cg02290350 chr8:58132656 NA -0.59 -8.33 -0.42 2.25e-15 Developmental language disorder (linguistic errors); CRC cis rs4665809 1.000 rs750452 chr2:26324995 G/A cg25036284 chr2:26402008 FAM59B -0.46 -5.97 -0.31 6e-9 Gut microbiome composition (summer); CRC cis rs990171 1.000 rs4851584 chr2:103060313 A/G cg03938978 chr2:103052716 IL18RAP 0.45 5.76 0.3 1.88e-8 Lymphocyte counts; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg07228441 chr8:681215 ERICH1 -0.44 -7.0 -0.36 1.48e-11 Myopia (pathological); CRC cis rs10540 1.000 rs12801148 chr11:511707 T/G cg19913688 chr11:428466 ANO9 -0.69 -7.03 -0.36 1.22e-11 Body mass index; CRC cis rs4665809 0.590 rs6749046 chr2:26429451 C/G cg08067268 chr2:26466485 HADHB;HADHA 0.66 8.57 0.43 4.05e-16 Gut microbiome composition (summer); CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg17589437 chr7:87563717 ADAM22 -0.38 -6.17 -0.32 2.05e-9 Myopia (pathological); CRC cis rs2625529 0.652 rs11634608 chr15:72255718 A/G cg16672083 chr15:72433130 SENP8 0.48 7.12 0.37 6.72e-12 Red blood cell count; CRC cis rs9747201 0.963 rs4789729 chr17:80146089 G/A cg09264619 chr17:80180166 NA -0.5 -7.24 -0.37 3.21e-12 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs12477438 0.765 rs28648058 chr2:99696417 G/A cg26064155 chr2:99771622 LIPT1;TSGA10 -0.63 -8.54 -0.43 5.03e-16 Chronic sinus infection; CRC cis rs6570726 0.720 rs412623 chr6:145883257 C/A cg23711669 chr6:146136114 FBXO30 0.67 11.23 0.53 5.25e-25 Lobe attachment (rater-scored or self-reported); CRC cis rs6445967 1.000 rs12637163 chr3:58317692 A/G cg23715586 chr3:58305044 RPP14 0.36 6.07 0.32 3.44e-9 Platelet count; CRC cis rs9811920 0.809 rs4577503 chr3:99657922 G/A cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G -0.4 -5.6 -0.3 4.42e-8 Axial length; CRC cis rs4665809 0.590 rs2384361 chr2:26452209 T/C cg22920501 chr2:26401640 FAM59B -0.84 -12.06 -0.55 5.65e-28 Gut microbiome composition (summer); CRC cis rs1707322 1.000 rs1613296 chr1:46546852 A/C cg06784218 chr1:46089804 CCDC17 -0.52 -9.08 -0.45 1e-17 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs601339 1.000 rs509548 chr12:123181855 T/A cg22192744 chr12:123187474 GPR109A -0.39 -5.61 -0.3 4.26e-8 Adiponectin levels; CRC cis rs4713118 0.869 rs9461405 chr6:27719375 G/T cg15845792 chr6:28175446 NA 0.64 8.94 0.44 2.95e-17 Parkinson's disease; CRC cis rs9399135 0.904 rs4895438 chr6:135317665 G/T cg24558204 chr6:135376177 HBS1L 0.52 8.14 0.41 8.36e-15 Red blood cell count; CRC cis rs9325144 0.513 rs7977596 chr12:38649067 C/A cg26384229 chr12:38710491 ALG10B -0.56 -8.38 -0.42 1.54e-15 Morning vs. evening chronotype; CRC cis rs7666738 0.791 rs10033994 chr4:98969582 C/T cg05340658 chr4:99064831 C4orf37 0.6 9.35 0.46 1.41e-18 Colonoscopy-negative controls vs population controls; CRC cis rs9818758 0.545 rs9853352 chr3:49813258 C/T cg01304814 chr3:48885189 PRKAR2A -0.78 -6.35 -0.33 7.12e-10 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; CRC cis rs4363385 0.776 rs1415957 chr1:152948909 A/G cg25856811 chr1:152973957 SPRR3 -0.22 -6.15 -0.32 2.22e-9 Inflammatory skin disease; CRC cis rs9894429 1.000 rs9747349 chr17:79584297 C/T cg18240062 chr17:79603768 NPLOC4 0.56 9.34 0.46 1.54e-18 Eye color traits; CRC cis rs9826463 0.757 rs73238195 chr3:142171525 A/C cg20824294 chr3:142316082 PLS1 0.36 6.28 0.33 1.05e-9 QRS duration in Tripanosoma cruzi seropositivity; CRC cis rs2632516 1.000 rs2526378 chr17:56404349 A/G cg12560992 chr17:57184187 TRIM37 0.4 5.67 0.3 3.16e-8 Alzheimer's disease;Alzheimer's disease in APOE e4- carriers;Monocyte count; CRC cis rs877282 1.000 rs877282 chr10:771532 G/A cg17470449 chr10:769945 NA 0.63 8.46 0.42 8.85e-16 Uric acid levels; CRC cis rs9443645 0.527 rs3902856 chr6:79699837 C/T cg05283184 chr6:79620031 NA -0.44 -6.31 -0.33 9.05e-10 Intelligence (multi-trait analysis); CRC cis rs6456156 0.586 rs720325 chr6:167467349 G/T cg07741184 chr6:167504864 NA 0.39 6.76 0.35 6.46e-11 Primary biliary cholangitis; CRC cis rs4862750 0.914 rs11943333 chr4:187872455 A/G cg03647317 chr4:187891568 NA -0.49 -8.78 -0.44 9.39e-17 Lobe attachment (rater-scored or self-reported); CRC cis rs56313388 0.521 rs62039274 chr16:56328813 G/T cg02433656 chr16:56322654 GNAO1 0.52 7.57 0.39 3.79e-13 Pulse pressure; CRC cis rs11723261 0.621 rs7692530 chr4:123445 G/C cg12746427 chr4:53362 ZNF718;ZNF595 0.46 6.18 0.32 1.89e-9 Immune response to smallpox vaccine (IL-6); CRC cis rs3858526 0.642 rs55732658 chr11:5894602 A/C cg05234568 chr11:5960015 NA -0.53 -6.86 -0.35 3.39e-11 DNA methylation (variation); CRC trans rs208520 0.955 rs208532 chr6:66961280 T/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.89 -11.02 -0.52 2.96e-24 Exhaled nitric oxide output; CRC cis rs9462027 0.628 rs6899938 chr6:34749113 A/G cg07306190 chr6:34760872 UHRF1BP1 -0.35 -6.24 -0.33 1.31e-9 Systemic lupus erythematosus; CRC cis rs7615952 0.599 rs7652883 chr3:125707977 T/G cg15145296 chr3:125709740 NA -0.56 -6.72 -0.35 8.17e-11 Blood pressure (smoking interaction); CRC cis rs7584330 0.518 rs11888077 chr2:238424763 G/A cg14458575 chr2:238380390 NA 0.8 9.92 0.48 1.87e-20 Prostate cancer; CRC cis rs294883 0.821 rs9365036 chr6:159703779 C/T cg14500486 chr6:159655392 FNDC1 -0.35 -5.75 -0.3 2.09e-8 Coronary artery disease; CRC cis rs4713118 0.738 rs200465 chr6:27757654 T/A cg08798685 chr6:27730294 NA -0.48 -6.81 -0.35 4.53e-11 Parkinson's disease; CRC cis rs79349575 0.783 rs62075820 chr17:46983171 G/C cg00947319 chr17:47005597 UBE2Z -0.34 -5.91 -0.31 8.38e-9 Type 2 diabetes; CRC cis rs7769051 0.803 rs59740783 chr6:133231711 G/A cg22852734 chr6:133119734 C6orf192 0.9 10.14 0.49 3.28e-21 Type 2 diabetes nephropathy; CRC cis rs13256369 0.851 rs13267036 chr8:8566685 G/A cg06636001 chr8:8085503 FLJ10661 0.48 5.99 0.31 5.6e-9 Obesity-related traits; CRC cis rs10189230 0.868 rs5002064 chr2:222353508 G/A cg14652038 chr2:222343519 EPHA4 0.52 10.02 0.48 8.14e-21 Urate levels in lean individuals; CRC cis rs9556958 0.708 rs9513435 chr13:99160334 C/G cg07423050 chr13:99094983 FARP1 -0.43 -6.37 -0.33 6.4e-10 Educational attainment (years of education); CRC cis rs9916302 0.904 rs4795384 chr17:37716771 C/G cg00129232 chr17:37814104 STARD3 -0.55 -8.2 -0.41 5.27e-15 Glomerular filtration rate (creatinine); CRC cis rs12594515 0.967 rs71405295 chr15:45988921 T/C cg19682013 chr15:45996608 NA 0.32 6.7 0.35 9.09e-11 Waist circumference;Weight; CRC cis rs7833790 0.724 rs6473310 chr8:82707981 A/G cg17211192 chr8:82754475 SNX16 -0.48 -6.77 -0.35 5.91e-11 Diastolic blood pressure; CRC cis rs7605827 0.836 rs9287659 chr2:15595755 C/T cg19274914 chr2:15703543 NA 0.39 6.03 0.32 4.51e-9 Educational attainment (years of education); CRC cis rs12410462 1.000 rs12407171 chr1:227642282 G/A cg23173402 chr1:227635558 NA 0.7 8.02 0.4 1.91e-14 Major depressive disorder; CRC cis rs7546094 1.000 rs12126277 chr1:113106369 A/G cg22162597 chr1:113214053 CAPZA1 0.43 5.94 0.31 7.2e-9 Platelet distribution width; CRC cis rs28386778 0.865 rs2727276 chr17:61929709 G/A cg25654072 chr17:61904446 PSMC5;FTSJ3 0.69 10.71 0.51 3.81e-23 Prudent dietary pattern; CRC cis rs6120849 0.663 rs6088662 chr20:33547633 A/C cg24642439 chr20:33292090 TP53INP2 0.46 6.18 0.32 1.91e-9 Protein C levels; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg02299360 chr1:203275326 BTG2 0.45 6.26 0.33 1.2e-9 Response to antipsychotic treatment; CRC cis rs208520 0.690 rs12198297 chr6:66714665 G/A cg07460842 chr6:66804631 NA 1.06 14.77 0.63 3.26e-38 Exhaled nitric oxide output; CRC cis rs4285028 0.948 rs12493952 chr3:121708497 C/T cg20356878 chr3:121714668 ILDR1 -0.49 -7.18 -0.37 4.66e-12 Multiple sclerosis; CRC cis rs1448094 0.512 rs7970842 chr12:86243258 C/T cg19622623 chr12:86230825 RASSF9 -0.41 -6.68 -0.35 1.01e-10 Major depressive disorder; CRC cis rs4665809 0.941 rs6735145 chr2:26270302 T/C cg22920501 chr2:26401640 FAM59B -0.52 -7.16 -0.37 5.45e-12 Gut microbiome composition (summer); CRC cis rs4925540 0.550 rs7519943 chr1:247175127 A/G cg22502715 chr1:247171572 ZNF695 0.42 6.09 0.32 3.1e-9 Response to taxane treatment (docetaxel); CRC cis rs11997175 0.574 rs872489 chr8:33646401 T/C cg04338863 chr8:33670619 NA 0.4 6.84 0.35 3.8e-11 Body mass index; CRC trans rs7615952 0.546 rs2979306 chr3:125312130 C/A cg21747405 chr11:67723411 NA -0.5 -6.6 -0.34 1.69e-10 Blood pressure (smoking interaction); CRC cis rs9818941 0.824 rs2712318 chr3:157776053 C/T cg08654915 chr3:157813417 NA -0.32 -5.95 -0.31 7.04e-9 Height; CRC cis rs3820068 0.734 rs6674806 chr1:15902656 A/G cg27534772 chr1:16042836 PLEKHM2 0.43 7.02 0.36 1.25e-11 Systolic blood pressure; CRC cis rs7705042 0.828 rs249638 chr5:141530696 G/C cg07392085 chr5:141489673 NDFIP1 0.46 7.35 0.38 1.6e-12 Asthma; CRC cis rs929354 0.772 rs1182432 chr7:157029176 A/G cg16102536 chr7:156981717 UBE3C 0.41 6.91 0.36 2.57e-11 Body mass index; CRC cis rs3772130 1.000 rs3732408 chr3:121421179 G/A cg20356878 chr3:121714668 ILDR1 0.51 7.75 0.39 1.19e-13 Cognitive performance; CRC cis rs4074961 0.586 rs10908360 chr1:38058693 T/C cg13401533 chr1:37979913 MEAF6 0.45 6.28 0.33 1.05e-9 Axial length; CRC cis rs1712517 0.844 rs1163087 chr10:105043289 G/A cg05636881 chr10:105038444 INA 0.48 8.1 0.41 1.07e-14 Migraine; CRC cis rs7666738 0.830 rs6817645 chr4:99016054 T/C cg05340658 chr4:99064831 C4orf37 0.62 9.64 0.47 1.5700000000000001e-19 Colonoscopy-negative controls vs population controls; CRC cis rs10971721 0.822 rs10971793 chr9:33922626 A/G cg13495928 chr9:33750294 PRSS3 0.56 5.97 0.31 6.15e-9 Body mass index; CRC cis rs71403859 0.554 rs12373065 chr16:71870032 T/A cg03805757 chr16:71968109 PKD1L3 -0.66 -5.62 -0.3 4.14e-8 Post bronchodilator FEV1; CRC cis rs2290159 0.752 rs3773349 chr3:12649732 T/C cg23032965 chr3:12705835 RAF1 0.49 6.31 0.33 9.24e-10 Cholesterol, total; CRC cis rs995000 0.899 rs11207976 chr1:62976751 G/A cg19896129 chr1:63156450 NA 0.42 6.36 0.33 6.74e-10 Triglyceride levels; CRC cis rs9488822 0.676 rs11153593 chr6:116335131 C/A cg05304507 chr6:116381966 FRK 0.31 8.37 0.42 1.67e-15 Cholesterol, total;LDL cholesterol; CRC cis rs919433 0.963 rs10166569 chr2:198183439 G/A cg10820045 chr2:198174542 NA -0.53 -9.12 -0.45 7.78e-18 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC cis rs2235642 0.717 rs9937922 chr16:1658154 C/G cg26528668 chr16:1614120 IFT140 0.36 5.6 0.3 4.46e-8 Coronary artery disease; CRC cis rs853679 0.517 rs1947862 chr6:28105196 C/T cg12172441 chr6:28176163 NA 0.63 7.45 0.38 8.49e-13 Depression; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg04924415 chr12:100661456 SCYL2;DEPDC4 0.39 6.35 0.33 7.17e-10 Liver disease severity in Alagille syndrome; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg19603390 chr7:7222222 C1GALT1 0.46 6.47 0.34 3.57e-10 Anxiety disorder; CRC trans rs10504229 0.906 rs112793785 chr8:58190537 T/C cg04077850 chr5:125800366 GRAMD3 0.37 6.26 0.33 1.23e-9 Developmental language disorder (linguistic errors); CRC cis rs427941 0.609 rs4729776 chr7:101830064 A/G cg06246474 chr7:101738831 CUX1 0.41 6.03 0.32 4.4e-9 Plasma omega-3 polyunsaturated fatty acid level (eicosapentaenoic acid); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg10659575 chr11:102188233 BIRC3 0.46 6.59 0.34 1.74e-10 Response to antipsychotic treatment; CRC trans rs11098499 0.863 rs3822192 chr4:120445720 A/C cg25214090 chr10:38739885 LOC399744 0.63 9.71 0.47 9.06e-20 Corneal astigmatism; CRC cis rs2836950 0.565 rs7279497 chr21:40531306 A/G cg06238570 chr21:40685208 BRWD1 0.59 8.51 0.42 6.3e-16 Menarche (age at onset); CRC cis rs2742417 1.000 rs938362 chr3:45746365 T/C cg04837898 chr3:45731254 SACM1L -0.36 -5.92 -0.31 7.98e-9 Response to anti-depressant treatment in major depressive disorder; CRC cis rs4332037 0.851 rs28728306 chr7:1961814 C/A cg24505167 chr7:1915268 MAD1L1 -0.42 -5.89 -0.31 9.29e-9 Bipolar disorder; CRC cis rs9393777 0.513 rs13194053 chr6:27143883 T/C cg12292205 chr6:26970375 C6orf41 -0.76 -8.08 -0.41 1.29e-14 Intelligence (multi-trait analysis); CRC cis rs7584330 0.554 rs114331205 chr2:238432559 A/C cg14458575 chr2:238380390 NA 0.53 7.01 0.36 1.33e-11 Prostate cancer; CRC cis rs2050392 0.544 rs598672 chr10:30742388 C/T cg18806716 chr10:30721971 MAP3K8 -0.62 -8.91 -0.44 3.54e-17 Inflammatory bowel disease; CRC cis rs763121 0.853 rs1013338 chr22:38974154 C/A cg06544989 chr22:39130855 UNC84B 0.48 7.77 0.39 1.03e-13 Menopause (age at onset); CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg10490227 chr1:40348903 TRIT1 0.4 6.43 0.33 4.57e-10 Obesity-related traits; CRC trans rs9929218 1.000 rs12443730 chr16:68804342 T/C cg04657470 chr2:198365150 HSPE1;HSPD1 -0.83 -11.81 -0.55 4.43e-27 Colorectal cancer; CRC cis rs12900413 0.687 rs62023459 chr15:90308231 A/T cg24249390 chr15:90295951 MESP1 -0.57 -9.13 -0.45 7.11e-18 Coronary artery aneurysm in Kawasaki disease; CRC cis rs7666738 0.830 rs1120708 chr4:98931260 G/C cg05340658 chr4:99064831 C4orf37 0.6 9.35 0.46 1.41e-18 Colonoscopy-negative controls vs population controls; CRC cis rs1059312 0.808 rs900982 chr12:129304369 G/A cg21616243 chr12:129299702 MGC16384;SLC15A4 -0.74 -12.97 -0.58 2.26e-31 Systemic lupus erythematosus; CRC cis rs10193935 0.901 rs222479 chr2:42656857 T/G cg27598129 chr2:42591480 NA -0.63 -7.33 -0.37 1.75e-12 Colonoscopy-negative controls vs population controls; CRC cis rs28386778 0.897 rs57108948 chr17:61802378 T/C cg23090583 chr17:61904693 PSMC5;FTSJ3 1.03 19.28 0.73 5.63e-56 Prudent dietary pattern; CRC cis rs3820068 0.532 rs72647105 chr1:15935238 C/G cg27534772 chr1:16042836 PLEKHM2 0.53 10.36 0.5 5.76e-22 Systolic blood pressure; CRC cis rs992157 0.835 rs13005100 chr2:219151767 C/T cg04880052 chr2:219191631 PNKD -0.43 -6.8 -0.35 4.82e-11 Colorectal cancer; CRC cis rs6121246 0.909 rs6060870 chr20:30303299 C/T cg07809909 chr20:30433512 FOXS1 0.35 5.75 0.3 2.09e-8 Mean corpuscular hemoglobin; CRC cis rs2439831 0.681 rs956391 chr15:43617493 C/T cg02155558 chr15:43621948 ADAL;LCMT2 -0.67 -8.57 -0.43 4.11e-16 Lung cancer in ever smokers; CRC cis rs6912958 0.559 rs373646 chr6:88056896 A/G cg12350822 chr6:88032061 C6orf162;GJB7 0.46 9.53 0.47 3.55e-19 Monocyte percentage of white cells; CRC cis rs7829975 0.626 rs907183 chr8:8729761 C/G cg06636001 chr8:8085503 FLJ10661 -0.61 -9.58 -0.47 2.4e-19 Mood instability; CRC cis rs932541 0.955 rs6043995 chr20:16457916 T/C cg17003395 chr20:16555519 KIF16B 0.41 5.7 0.3 2.7e-8 Intelligence; CRC cis rs11190604 1.000 rs2273694 chr10:102256496 G/T cg07080220 chr10:102295463 HIF1AN 0.48 5.81 0.31 1.44e-8 Palmitoleic acid (16:1n-7) levels; CRC cis rs6502050 0.799 rs4789681 chr17:80100546 G/A cg09264619 chr17:80180166 NA -0.34 -5.81 -0.3 1.5e-8 Life satisfaction; CRC cis rs10540 1.000 rs12419766 chr11:503710 C/T cg03576123 chr11:487126 PTDSS2 -1.04 -10.79 -0.51 1.91e-23 Body mass index; CRC cis rs9491140 0.539 rs11154230 chr6:124686156 A/G cg22366943 chr6:124882293 NKAIN2 0.56 8.42 0.42 1.21e-15 Neuroticism; CRC cis rs477692 0.905 rs563859 chr10:131417586 T/C cg05714579 chr10:131428358 MGMT 0.59 8.5 0.42 6.65e-16 Response to temozolomide; CRC cis rs9911578 1.000 rs1057068 chr17:56598439 T/C cg12560992 chr17:57184187 TRIM37 -0.91 -17.12 -0.69 1.97e-47 Intelligence (multi-trait analysis); CRC cis rs7264396 0.580 rs2425181 chr20:34447709 T/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.57 -8.43 -0.42 1.13e-15 Total cholesterol levels; CRC cis rs9814567 0.964 rs3856729 chr3:134200925 A/G cg06109529 chr3:134205091 CEP63;ANAPC13 -0.83 -12.64 -0.57 3.91e-30 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs1062746 0.738 rs2303764 chr16:87377455 C/G cg02258303 chr16:87377426 FBXO31 0.67 11.31 0.53 2.88e-25 Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 2 peripheral neuropathy); CRC cis rs2070488 1.000 rs2268757 chr3:38505853 C/T cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.91 17.2 0.69 9.93e-48 Electrocardiographic conduction measures; CRC trans rs34102591 0.826 rs71458829 chr12:124470747 G/A cg07736115 chr13:113771937 F7 0.53 6.27 0.33 1.15e-9 Schizophrenia; CRC cis rs79149102 0.579 rs74023908 chr15:75310710 T/C cg09165964 chr15:75287851 SCAMP5 -0.65 -6.29 -0.33 1.02e-9 Lung cancer; CRC cis rs172166 0.694 rs1631552 chr6:28089699 C/A cg06470822 chr6:28175283 NA 0.8 11.86 0.55 2.9e-27 Cardiac Troponin-T levels; CRC cis rs2404602 0.583 rs12908334 chr15:76581592 C/T cg03037974 chr15:76606532 NA 0.84 17.29 0.69 4.28e-48 Blood metabolite levels; CRC cis rs10504229 0.683 rs55714371 chr8:58131846 T/G cg24829409 chr8:58192753 C8orf71 -0.55 -8.03 -0.4 1.71e-14 Developmental language disorder (linguistic errors); CRC cis rs67311347 1.000 rs17078813 chr3:40434162 C/T cg24209194 chr3:40518798 ZNF619 0.4 5.78 0.3 1.73e-8 Renal cell carcinoma; CRC cis rs2302190 0.941 rs6503865 chr17:56549672 A/C cg25885038 chr17:56607967 SEPT4 -0.42 -6.16 -0.32 2.09e-9 Vitamin D levels; CRC trans rs208520 0.909 rs62414639 chr6:67023706 G/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.82 9.87 0.48 2.74e-20 Exhaled nitric oxide output; CRC trans rs41997 0.785 rs2110215 chr7:118071216 C/T cg24080313 chr3:55522631 WNT5A -0.44 -6.08 -0.32 3.27e-9 Response to platinum-based chemotherapy in non-small-cell lung cancer; CRC cis rs2625529 0.730 rs6494990 chr15:72401074 T/A cg16672083 chr15:72433130 SENP8 0.41 6.05 0.32 3.96e-9 Red blood cell count; CRC cis rs2976388 0.609 rs2572908 chr8:143802636 A/G cg20041105 chr8:143859282 LYNX1 0.43 7.62 0.39 2.65e-13 Urinary tract infection frequency; CRC cis rs7072216 0.763 rs6584201 chr10:100170209 T/C cg26618903 chr10:100175079 PYROXD2 -0.55 -9.16 -0.45 5.81e-18 Metabolite levels; CRC trans rs7027930 0.520 rs11790989 chr9:606602 G/A cg27061366 chr19:13044373 FARSA 0.5 6.06 0.32 3.74e-9 Pulmonary function decline; CRC cis rs801193 0.548 rs7805152 chr7:66209253 C/T cg18876405 chr7:65276391 NA 0.51 8.26 0.41 3.52e-15 Aortic root size; CRC cis rs7626444 0.628 rs1684464 chr3:196485514 A/C cg12930392 chr3:196481615 PAK2 0.39 7.11 0.36 7.25e-12 Monocyte count; CRC cis rs3796352 1.000 rs13092352 chr3:52969697 C/T cg07884673 chr3:53033167 SFMBT1 0.69 6.12 0.32 2.67e-9 Immune reponse to smallpox (secreted IL-2); CRC cis rs2346160 0.899 rs206977 chr6:167690746 G/C cg04673565 chr6:167680447 NA -0.39 -6.31 -0.33 8.78e-10 Parental extreme longevity (95 years and older); CRC cis rs6952808 0.723 rs55689856 chr7:2037215 G/A cg04267008 chr7:1944627 MAD1L1 -0.77 -11.27 -0.53 3.82e-25 Bipolar disorder and schizophrenia; CRC cis rs208520 1.000 rs12189683 chr6:66977716 A/C cg07460842 chr6:66804631 NA -0.9 -11.17 -0.52 9.15e-25 Exhaled nitric oxide output; CRC cis rs877282 0.898 rs11253341 chr10:765008 G/C cg06581033 chr10:766294 NA -0.53 -5.88 -0.31 1.01e-8 Uric acid levels; CRC cis rs10193935 0.901 rs222478 chr2:42656919 G/T cg27598129 chr2:42591480 NA -0.58 -7.26 -0.37 2.8e-12 Colonoscopy-negative controls vs population controls; CRC cis rs73200209 1.000 rs73200209 chr12:116555786 A/T cg01776926 chr12:116560359 MED13L -0.5 -6.19 -0.32 1.83e-9 Total body bone mineral density; CRC cis rs4819052 0.851 rs34101026 chr21:46662200 C/T cg19498844 chr21:46707878 POFUT2;LOC642852 0.77 11.02 0.52 3.04e-24 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs11864453 1.000 rs7185407 chr16:72034957 A/T cg01557791 chr16:72042693 DHODH 0.54 7.42 0.38 9.77e-13 Fibrinogen levels; CRC cis rs139156536 1 rs139156536 chr17:38164432 TTTTA/T cg17344932 chr17:38183730 MED24;SNORD124 -0.7 -12.86 -0.58 5.87e-31 Lymphocyte percentage of white cells; CRC cis rs35146811 0.586 rs12666107 chr7:99778019 G/C cg13334819 chr7:99746414 C7orf59 -0.47 -5.7 -0.3 2.65e-8 Coronary artery disease; CRC cis rs72945132 0.882 rs3781648 chr11:70190058 T/C cg00319359 chr11:70116639 PPFIA1 0.57 6.23 0.32 1.43e-9 Coronary artery disease; CRC cis rs7208859 0.725 rs7210904 chr17:29170205 G/A cg13385521 chr17:29058706 SUZ12P 0.55 7.33 0.37 1.79e-12 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs4862750 0.832 rs9995958 chr4:187901764 G/A cg03647317 chr4:187891568 NA -0.54 -10.28 -0.49 1.09e-21 Lobe attachment (rater-scored or self-reported); CRC cis rs7208859 0.623 rs12103440 chr17:29086657 A/G cg13385521 chr17:29058706 SUZ12P 0.73 8.4 0.42 1.39e-15 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC trans rs7395662 0.504 rs2019666 chr11:48437729 C/T cg15704280 chr7:45808275 SEPT13 -0.49 -7.03 -0.36 1.17e-11 HDL cholesterol; CRC cis rs10256972 0.706 rs12701970 chr7:1121958 T/C cg22907277 chr7:1156413 C7orf50 0.7 10.69 0.51 4.39e-23 Longevity;Endometriosis; CRC cis rs875971 0.545 rs1267814 chr7:66044409 G/A cg18876405 chr7:65276391 NA -0.45 -6.31 -0.33 8.92e-10 Aortic root size; CRC cis rs4728302 0.838 rs10225115 chr7:133591435 C/T cg03336402 chr7:133662267 EXOC4 -0.44 -6.43 -0.33 4.45e-10 Intelligence;Intelligence (multi-trait analysis); CRC cis rs1552244 0.882 rs13099507 chr3:10031603 G/A cg02579736 chr3:10068473 FANCD2;CIDECP 0.93 11.04 0.52 2.63e-24 Alzheimer's disease; CRC trans rs1814175 0.715 rs7479622 chr11:49673340 T/G cg11707556 chr5:10655725 ANKRD33B -0.43 -7.95 -0.4 2.97e-14 Height; CRC cis rs12760731 0.720 rs35781686 chr1:178261262 G/A cg00404053 chr1:178313656 RASAL2 1.1 11.2 0.53 7.14e-25 Obesity-related traits; CRC cis rs11122272 0.735 rs2749707 chr1:231527316 C/T cg06096015 chr1:231504339 EGLN1 0.41 6.12 0.32 2.72e-9 Hemoglobin concentration; CRC cis rs2019137 0.539 rs11123170 chr2:113978940 C/G cg21610815 chr2:113994035 PAX8;LOC654433;LOC440839 0.6 8.69 0.43 1.73e-16 Lymphocyte counts; CRC cis rs311392 0.966 rs454975 chr8:55087514 T/C cg20636351 chr8:55087400 NA -0.33 -5.9 -0.31 9.15e-9 Pelvic organ prolapse (moderate/severe); CRC cis rs7666738 0.830 rs921522 chr4:98841608 C/T cg17366294 chr4:99064904 C4orf37 0.39 6.22 0.32 1.52e-9 Colonoscopy-negative controls vs population controls; CRC trans rs679582 0.864 rs4896468 chr6:139838710 T/C cg24871798 chr6:50817450 NA -0.36 -6.35 -0.33 7.05e-10 Blood trace element (Se levels); CRC cis rs853679 0.517 rs9380062 chr6:28137569 G/A cg18032046 chr6:28092343 ZSCAN16 -0.51 -5.93 -0.31 7.47e-9 Depression; CRC cis rs875971 0.522 rs2008188 chr7:65429013 G/C cg02869306 chr7:64672164 INTS4L1 -0.35 -5.88 -0.31 1e-8 Aortic root size; CRC cis rs41271951 0.512 rs79122717 chr1:151093526 G/A cg11822372 chr1:151115635 SEMA6C -0.71 -5.69 -0.3 2.75e-8 Blood protein levels; CRC cis rs2303759 0.874 rs8108669 chr19:49845895 C/T cg22307029 chr19:49891270 CCDC155 0.65 9.3 0.46 2.09e-18 Multiple sclerosis; CRC cis rs6952808 0.531 rs3779003 chr7:2184902 C/T cg02951883 chr7:2050386 MAD1L1 -0.59 -9.18 -0.45 4.89e-18 Bipolar disorder and schizophrenia; CRC cis rs11098499 0.913 rs67073020 chr4:120152557 C/T cg24375607 chr4:120327624 NA 0.44 6.5 0.34 2.89e-10 Corneal astigmatism; CRC cis rs2075371 0.637 rs2544165 chr7:133920443 A/G cg11752832 chr7:134001865 SLC35B4 -0.41 -5.93 -0.31 7.6e-9 Mean platelet volume; CRC cis rs6908034 0.556 rs7750703 chr6:19804814 C/G cg02682789 chr6:19804855 NA 0.79 7.65 0.39 2.23e-13 Endometriosis;Deep ovarian and/or rectovaginal disease with dense adhesions; CRC cis rs1577917 0.917 rs1838959 chr6:86556804 T/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.51 -6.59 -0.34 1.76e-10 Response to antipsychotic treatment; CRC trans rs6500957 0.920 rs17648524 chr16:7459683 C/G cg15368822 chr1:226070397 TMEM63A 0.41 5.98 0.31 5.86e-9 Spherical equivalent (joint analysis main effects and education interaction); CRC cis rs1552244 0.572 rs3894323 chr3:10168967 G/A cg16606324 chr3:10149918 C3orf24 0.66 7.77 0.39 9.99e-14 Alzheimer's disease; CRC cis rs919433 0.783 rs787980 chr2:198239225 C/T cg10820045 chr2:198174542 NA 0.45 8.01 0.4 1.99e-14 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC cis rs8060686 0.920 rs58588228 chr16:67802010 C/T cg10544611 chr16:67998164 SLC12A4 -0.53 -5.64 -0.3 3.66e-8 HDL cholesterol;Metabolic syndrome; CRC cis rs9491140 0.539 rs11154232 chr6:124691494 G/A cg05308643 chr6:124982296 NKAIN2 0.54 7.08 0.36 8.52e-12 Neuroticism; CRC cis rs2952156 0.920 rs732083 chr17:37834367 G/A cg11212589 chr17:38028394 ZPBP2 0.34 5.96 0.31 6.5e-9 Asthma; CRC cis rs929354 0.772 rs2301916 chr7:156974127 G/T cg05182265 chr7:156933206 UBE3C -0.76 -14.36 -0.62 1.17e-36 Body mass index; CRC cis rs1707322 0.656 rs2991981 chr1:46057144 A/G cg03146154 chr1:46216737 IPP -0.67 -9.72 -0.47 8.26e-20 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs7615952 0.599 rs66532274 chr3:125731845 G/A cg05084668 chr3:125655381 ALG1L -0.52 -8.43 -0.42 1.11e-15 Blood pressure (smoking interaction); CRC cis rs9926296 0.605 rs6500453 chr16:89858657 C/G cg04287289 chr16:89883240 FANCA 0.82 14.81 0.63 2.23e-38 Vitiligo; CRC cis rs7119 0.717 rs62007350 chr15:77804590 G/A cg27398640 chr15:77910606 LINGO1 -0.46 -7.98 -0.4 2.48e-14 Type 2 diabetes; CRC cis rs4819052 0.851 rs2838832 chr21:46664904 A/G cg02159808 chr21:46707872 POFUT2;LOC642852 -0.47 -5.99 -0.31 5.52e-9 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs910316 0.967 rs2268619 chr14:75640354 C/G cg08847533 chr14:75593920 NEK9 -0.91 -15.32 -0.65 2.25e-40 Height; CRC cis rs2762353 0.574 rs34067542 chr6:25728210 T/A cg12310025 chr6:25882481 NA 0.75 10.78 0.51 2.06e-23 Blood metabolite levels; CRC cis rs1383484 0.545 rs7171383 chr15:84644839 T/A cg11189052 chr15:85197271 WDR73 -0.48 -5.71 -0.3 2.49e-8 Height; CRC cis rs763121 0.853 rs1056610 chr22:39080078 C/T cg06544989 chr22:39130855 UNC84B -0.47 -7.41 -0.38 1.09e-12 Menopause (age at onset); CRC cis rs644148 0.836 rs2686770 chr19:44998773 A/G cg15540054 chr19:45004280 ZNF180 -0.56 -7.93 -0.4 3.49e-14 Personality dimensions; CRC cis rs2239547 0.522 rs6770957 chr3:52995416 T/C cg11645453 chr3:52864694 ITIH4 0.52 9.0 0.44 1.87e-17 Schizophrenia; CRC cis rs2243480 1.000 rs34192067 chr7:65887657 C/A cg25985355 chr7:65971099 NA -0.53 -5.98 -0.31 5.75e-9 Diabetic kidney disease; CRC cis rs6500602 0.855 rs1139652 chr16:4476089 T/C cg08645402 chr16:4508243 NA 0.55 8.04 0.41 1.61e-14 Schizophrenia; CRC cis rs9463078 0.547 rs1418434 chr6:44748365 C/T cg25276700 chr6:44698697 NA -0.3 -7.64 -0.39 2.33e-13 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; CRC cis rs4658101 0.774 rs11165008 chr1:92050615 T/C cg24006770 chr1:92056542 NA 0.46 6.84 0.35 3.97e-11 Optic disc area;Vertical cup-disc ratio; CRC cis rs4750440 0.576 rs2447011 chr10:14032199 C/T cg00551146 chr10:14014579 FRMD4A 0.45 8.0 0.4 2.18e-14 Adiponectin levels; CRC cis rs892961 0.806 rs312910 chr17:75413961 A/C cg05865280 chr17:75406074 SEPT9 0.65 15.42 0.65 9.31e-41 Airflow obstruction; CRC cis rs7208859 0.673 rs73277978 chr17:29191449 A/G cg13385521 chr17:29058706 SUZ12P 0.69 8.01 0.4 2.02e-14 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs2777491 0.957 rs2015781 chr15:41648967 C/G cg18705301 chr15:41695430 NDUFAF1 -0.69 -11.28 -0.53 3.61e-25 Ulcerative colitis; CRC cis rs2072499 0.722 rs61462713 chr1:156161682 C/T cg24450063 chr1:156163899 SLC25A44 1.07 16.9 0.68 1.41e-46 Testicular germ cell tumor; CRC cis rs490234 0.702 rs12553882 chr9:128195044 G/A cg14078157 chr9:128172775 NA -0.4 -6.25 -0.33 1.29e-9 Mean arterial pressure; CRC cis rs2949837 0.581 rs2960434 chr7:45972977 A/G cg04727332 chr7:45960243 IGFBP3 0.36 5.74 0.3 2.18e-8 Sitting height ratio; CRC cis rs7274811 0.744 rs209665 chr20:32128889 T/G cg07470512 chr20:32255052 NECAB3;C20orf134 -0.47 -6.48 -0.34 3.39e-10 Height; CRC cis rs7447593 0.626 rs3812036 chr5:176813404 C/T cg17261708 chr5:176794207 RGS14 0.57 8.47 0.42 8.56e-16 Urinary electrolytes (magnesium/calcium ratio); CRC cis rs4713118 0.699 rs573179 chr6:27849676 C/A cg12172441 chr6:28176163 NA 0.49 6.04 0.32 4.14e-9 Parkinson's disease; CRC trans rs10090774 0.841 rs13438888 chr8:141841942 A/T cg14360659 chr9:137029702 RNU6ATAC -0.46 -6.05 -0.32 3.96e-9 Acute graft versus host disease in bone marrow transplantation (recipient effect); CRC cis rs11971779 0.793 rs11764426 chr7:139024050 C/G cg07862535 chr7:139043722 LUC7L2 0.79 10.27 0.49 1.23e-21 Diisocyanate-induced asthma; CRC cis rs60871478 1.000 rs35488064 chr7:812722 G/C cg04727924 chr7:799746 HEATR2 -0.46 -6.87 -0.35 3.26e-11 Cerebrospinal P-tau181p levels; CRC cis rs561341 0.824 rs1978115 chr17:30220776 A/C cg23018236 chr17:30244563 NA -0.57 -7.09 -0.36 8e-12 Hip circumference adjusted for BMI; CRC cis rs881375 0.933 rs7859805 chr9:123664123 A/G cg14255062 chr9:123606675 PSMD5;LOC253039 0.42 6.06 0.32 3.7e-9 Rheumatoid arthritis; CRC cis rs1448094 0.967 rs6539934 chr12:86343973 G/A cg19622623 chr12:86230825 RASSF9 -0.36 -5.81 -0.31 1.46e-8 Major depressive disorder; CRC cis rs2304069 0.954 rs9324638 chr5:149400718 A/G cg22760475 chr5:149380129 HMGXB3;TIGD6 -0.92 -10.39 -0.5 4.8e-22 HIV-1 control; CRC cis rs4665809 0.590 rs2384361 chr2:26452209 T/C cg08067268 chr2:26466485 HADHB;HADHA -0.65 -8.25 -0.41 3.91e-15 Gut microbiome composition (summer); CRC cis rs554111 0.636 rs10916935 chr1:21432112 T/C cg02927042 chr1:21476669 EIF4G3 0.37 5.6 0.3 4.51e-8 Facial morphology (factor 17, height of vermillion upper lip); CRC cis rs2456568 0.867 rs7935801 chr11:93658000 G/A cg26875233 chr11:93583750 C11orf90 -0.33 -6.26 -0.33 1.2e-9 Response to serotonin reuptake inhibitors in major depressive disorder; CRC cis rs708547 0.874 rs1401190 chr4:57885174 T/C cg25525207 chr4:57843836 C4orf14;POLR2B -0.47 -5.82 -0.31 1.42e-8 Response to bleomycin (chromatid breaks); CRC cis rs2014572 1.000 rs2014572 chr19:57760018 G/A cg12963866 chr19:57752005 ZNF805 -0.42 -6.22 -0.32 1.5e-9 Hyperactive-impulsive symptoms; CRC cis rs7927771 1.000 rs10838748 chr11:47716381 T/G cg20307385 chr11:47447363 PSMC3 -0.49 -6.62 -0.34 1.45e-10 Subjective well-being; CRC trans rs7267979 1.000 rs6076339 chr20:25348712 T/C cg17903999 chr18:56338584 MALT1 0.41 6.7 0.35 8.89e-11 Liver enzyme levels (alkaline phosphatase); CRC cis rs10504229 0.595 rs79077737 chr8:58117520 G/A cg02290350 chr8:58132656 NA -0.58 -7.96 -0.4 2.9e-14 Developmental language disorder (linguistic errors); CRC cis rs10504229 0.683 rs7820559 chr8:58142662 C/T cg22535103 chr8:58192502 C8orf71 -0.71 -9.45 -0.46 6.55e-19 Developmental language disorder (linguistic errors); CRC trans rs8035957 1.000 rs4924273 chr15:38846738 C/G cg18960307 chr17:4699574 PSMB6 -0.48 -6.17 -0.32 2.02e-9 Type 1 diabetes; CRC cis rs4665809 1.000 rs1371553 chr2:26262948 G/A cg25036284 chr2:26402008 FAM59B -0.46 -6.0 -0.31 5.15e-9 Gut microbiome composition (summer); CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg25563616 chr16:8962190 CARHSP1 0.47 6.19 0.32 1.75e-9 Thyroid stimulating hormone; CRC cis rs3812049 0.826 rs17764730 chr5:127357526 A/G cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.78 9.36 0.46 1.29e-18 Lymphocyte counts;Red cell distribution width; CRC trans rs4927850 0.752 rs7618864 chr3:195749561 G/A cg16724585 chr3:197361211 NA -0.46 -6.81 -0.35 4.75e-11 Pancreatic cancer; CRC cis rs7107174 1.000 rs901103 chr11:77931346 C/T cg02023728 chr11:77925099 USP35 0.49 7.24 0.37 3.29e-12 Testicular germ cell tumor; CRC cis rs738322 0.555 rs5750547 chr22:38546700 A/G cg03162506 chr22:38580953 NA -0.3 -6.14 -0.32 2.42e-9 Cutaneous nevi; CRC cis rs4363385 0.654 rs1129654 chr1:152958238 A/G cg25856811 chr1:152973957 SPRR3 -0.27 -7.45 -0.38 8.07e-13 Inflammatory skin disease; CRC trans rs7180079 0.620 rs12442852 chr15:64677413 A/G cg07470598 chr14:107239068 NA 0.42 5.99 0.31 5.46e-9 Monocyte count; CRC cis rs3018066 0.867 rs3113252 chr4:107252402 G/T cg01869342 chr4:106983673 TBCK 0.36 5.61 0.3 4.25e-8 Cancer; CRC cis rs853679 0.882 rs4713139 chr6:28092685 C/T cg15786705 chr6:28176104 NA 0.7 5.78 0.3 1.74e-8 Depression; CRC trans rs35110281 0.720 rs162400 chr21:44950305 A/C cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.5 8.31 0.42 2.61e-15 Mean corpuscular volume; CRC trans rs7267979 1.000 rs1077889 chr20:25267893 A/G cg17903999 chr18:56338584 MALT1 -0.41 -6.88 -0.35 3.09e-11 Liver enzyme levels (alkaline phosphatase); CRC cis rs6570726 0.935 rs110289 chr6:145865176 C/G cg23711669 chr6:146136114 FBXO30 0.7 12.39 0.56 3.35e-29 Lobe attachment (rater-scored or self-reported); CRC cis rs7589728 0.563 rs79892776 chr2:88470593 G/A cg14558114 chr2:88469736 THNSL2 0.59 5.98 0.31 5.79e-9 Plasma clusterin levels; CRC cis rs910316 0.687 rs175059 chr14:75490667 T/C cg03030879 chr14:75389066 RPS6KL1 0.42 6.39 0.33 5.64e-10 Height; CRC cis rs2635047 0.507 rs2668767 chr18:44785302 T/C cg19077165 chr18:44547161 KATNAL2 -0.38 -6.1 -0.32 3.03e-9 Educational attainment; CRC cis rs720844 0.748 rs6430323 chr2:149318579 G/C cg09247360 chr2:149335327 NA -0.56 -6.03 -0.32 4.49e-9 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs1008375 0.900 rs1003413 chr4:17582442 C/T cg16339924 chr4:17578868 LAP3 -0.63 -8.02 -0.4 1.82e-14 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs55788414 1.000 rs28395434 chr16:81182222 G/A cg06400318 chr16:81190750 PKD1L2 -0.6 -6.88 -0.35 3.02e-11 Left ventricular obstructive tract defect (maternal effect); CRC cis rs875971 1.000 rs12532998 chr7:65967459 A/C cg18876405 chr7:65276391 NA 0.51 8.79 0.44 8.39e-17 Aortic root size; CRC cis rs6504950 0.830 rs12150038 chr17:53041520 T/G cg26251398 chr17:52985966 TOM1L1 0.42 5.62 0.3 4.01e-8 Breast cancer; CRC cis rs9287719 0.578 rs10168852 chr2:10746323 C/A cg00105475 chr2:10696890 NA 0.46 7.18 0.37 4.56e-12 Prostate cancer; CRC cis rs7517126 1.000 rs2336503 chr1:196843420 G/T cg13682187 chr1:196946512 CFHR5 -0.34 -5.72 -0.3 2.41e-8 Blood protein levels; CRC cis rs4713675 0.565 rs9368773 chr6:33682541 C/A cg14003231 chr6:33640908 ITPR3 0.51 8.38 0.42 1.52e-15 Plateletcrit; CRC cis rs4790333 0.562 rs2447108 chr17:2257993 C/T cg02569219 chr17:2266849 SGSM2 0.4 6.65 0.34 1.2e-10 Proinsulin levels; CRC cis rs796364 1.000 rs281771 chr2:200812202 A/C cg25936922 chr2:200820526 C2orf60;C2orf47 -0.68 -7.52 -0.38 5.17e-13 Schizophrenia; CRC cis rs7945705 0.875 rs2653616 chr11:8885892 A/G cg12365402 chr11:9010492 NRIP3 -0.49 -8.23 -0.41 4.39e-15 Hemoglobin concentration; CRC cis rs12908161 1.000 rs56864281 chr15:85357649 C/A cg17507749 chr15:85114479 UBE2QP1 0.58 7.77 0.39 1.03e-13 Schizophrenia; CRC cis rs7493 0.901 rs17879517 chr7:95030646 T/C cg20119798 chr7:94954144 PON1 -0.47 -5.98 -0.31 5.95e-9 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs2019137 0.936 rs2305133 chr2:113956821 C/G cg21482265 chr2:113992762 PAX8;LOC440839;LOC654433 -0.46 -6.58 -0.34 1.87e-10 Lymphocyte counts; CRC cis rs1707322 0.686 rs1250 chr1:46094027 A/G cg06784218 chr1:46089804 CCDC17 0.66 11.99 0.55 9.84e-28 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC trans rs2797369 0.713 rs943909 chr6:101579289 A/C cg26346621 chr12:6873348 NA 0.4 6.24 0.33 1.36e-9 Renal function-related traits (eGRFcrea); CRC cis rs514406 0.679 rs499239 chr1:53310594 A/G cg24675658 chr1:53192096 ZYG11B -0.69 -10.27 -0.49 1.24e-21 Monocyte count; CRC cis rs57994353 0.897 rs11999532 chr9:139371405 G/C cg14119001 chr9:139324193 INPP5E -0.46 -6.45 -0.34 3.99e-10 Eosinophil counts;Cutaneous squamous cell carcinoma; CRC cis rs11628318 0.660 rs4906242 chr14:103085063 G/A cg12046867 chr14:103022105 NA -0.77 -9.19 -0.45 4.59e-18 Platelet count; CRC trans rs2303319 0.504 rs62189053 chr2:162624324 G/A cg20024234 chr21:43431083 ZNF295 -0.66 -5.96 -0.31 6.5e-9 Cognitive function; CRC cis rs6912958 0.500 rs3828759 chr6:87806640 T/C cg12350822 chr6:88032061 C6orf162;GJB7 -0.41 -7.69 -0.39 1.71e-13 Monocyte percentage of white cells; CRC cis rs6434928 1 rs6434928 chr2:198304577 G/A cg10820045 chr2:198174542 NA 0.38 6.38 0.33 5.88e-10 Autism spectrum disorder or schizophrenia;Schizophrenia; CRC cis rs1577917 0.916 rs7759727 chr6:86518878 A/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.51 -6.85 -0.35 3.57e-11 Response to antipsychotic treatment; CRC cis rs6860806 0.507 rs272891 chr5:131664394 G/T cg04518342 chr5:131593106 PDLIM4 0.43 6.95 0.36 1.98e-11 Breast cancer; CRC trans rs208520 1.000 rs12190316 chr6:66973365 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.84 10.1 0.49 4.52e-21 Exhaled nitric oxide output; CRC cis rs317689 0.658 rs479971 chr12:69672471 A/G cg14784868 chr12:69753453 YEATS4 0.44 5.71 0.3 2.49e-8 Response to diuretic therapy; CRC cis rs9925964 0.933 rs11150604 chr16:31037020 A/T cg02466173 chr16:30829666 NA 0.44 6.04 0.32 4.22e-9 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs9291683 0.595 rs11722930 chr4:10035454 G/A cg11266682 chr4:10021025 SLC2A9 0.53 11.16 0.52 9.86e-25 Bone mineral density; CRC cis rs1568889 1.000 rs16917689 chr11:28064466 G/A cg06544937 chr11:28130018 METT5D1;KIF18A 0.78 11.27 0.53 3.9e-25 Bipolar disorder; CRC cis rs7119 0.651 rs8041520 chr15:77839169 C/T cg10437265 chr15:77819839 NA 0.66 11.62 0.54 2.13e-26 Type 2 diabetes; CRC cis rs6534441 0.512 rs962939 chr4:125404239 A/G cg21609808 chr4:125404261 NA 0.5 7.48 0.38 6.66e-13 Major depressive disorder; CRC trans rs8073060 0.586 rs3859284 chr17:34012792 C/T cg19694781 chr19:47549865 TMEM160 -1.06 -14.24 -0.62 3.54e-36 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; CRC cis rs9517320 1.000 rs9517322 chr13:99126338 C/G cg20487152 chr13:99095054 FARP1 0.36 5.92 0.31 8.14e-9 Longevity; CRC cis rs6502050 0.723 rs11657069 chr17:80083809 C/T cg02741985 chr17:80059408 CCDC57 -0.44 -7.15 -0.37 5.61e-12 Life satisfaction; CRC cis rs4588572 0.606 rs2362828 chr5:77718835 C/T cg11547950 chr5:77652471 NA -0.49 -7.27 -0.37 2.64e-12 Triglycerides; CRC cis rs10504229 1.000 rs76023408 chr8:58193345 A/G cg01721255 chr8:58191610 C8orf71 0.51 6.37 0.33 6.37e-10 Developmental language disorder (linguistic errors); CRC cis rs11758351 0.866 rs77889957 chr6:26207435 A/G cg08260959 chr6:26240920 HIST1H4F -0.35 -5.83 -0.31 1.3e-8 Gout;Renal underexcretion gout; CRC cis rs9914988 0.832 rs4795462 chr17:27130991 C/T cg20469991 chr17:27169893 C17orf63 -0.6 -7.27 -0.37 2.59e-12 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs7833986 0.501 rs9650314 chr8:56903610 G/A cg23139584 chr8:56987506 RPS20;SNORD54 0.79 11.41 0.53 1.23e-25 Height; CRC cis rs6951245 0.832 rs79808627 chr7:1092519 C/G cg04025307 chr7:1156635 C7orf50 0.54 6.34 0.33 7.56e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC trans rs72991 0.639 rs1529579 chr11:121235871 G/T cg27192990 chr6:129479024 LAMA2 -0.44 -6.45 -0.34 4.07e-10 Response to tocilizumab in rheumatoid arthritis; CRC cis rs734999 0.967 rs10752745 chr1:2507938 A/G cg18854424 chr1:2615690 NA 0.31 5.89 0.31 9.4e-9 Ulcerative colitis; CRC cis rs9303280 0.806 rs34189114 chr17:38032460 C/T cg17344932 chr17:38183730 MED24;SNORD124 0.36 5.69 0.3 2.74e-8 Self-reported allergy; CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg20349076 chr11:118992192 HINFP 0.4 6.55 0.34 2.22e-10 Obesity-related traits; CRC cis rs798554 0.757 rs1182172 chr7:2878103 G/A cg19346786 chr7:2764209 NA -0.41 -7.01 -0.36 1.32e-11 Height; CRC cis rs13064411 0.696 rs7619913 chr3:113017503 A/G cg10517650 chr3:113235015 CCDC52 -0.38 -5.94 -0.31 7.08e-9 Response to simvastatin treatment (PCSK9 protein level change); CRC cis rs1799949 1.000 rs3092994 chr17:41215825 C/T cg05368731 chr17:41323189 NBR1 0.67 10.12 0.49 3.79e-21 Menopause (age at onset); CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg13972460 chr20:1165703 C20orf46 -0.39 -6.36 -0.33 6.86e-10 Myopia (pathological); CRC cis rs6076065 0.748 rs6048779 chr20:23374709 C/G cg11657817 chr20:23433608 CST11 0.53 8.88 0.44 4.53e-17 Facial morphology (factor 15, philtrum width); CRC cis rs7937682 0.921 rs34584980 chr11:111441537 G/A cg19812747 chr11:111475976 SIK2 0.52 7.61 0.39 2.94e-13 Primary sclerosing cholangitis; CRC cis rs2952156 1.000 rs2643194 chr17:37853048 C/T cg00129232 chr17:37814104 STARD3 -0.71 -11.56 -0.54 3.59e-26 Asthma; CRC trans rs10983614 1.000 rs7867776 chr9:120072627 A/G cg02934500 chr4:142557404 IL15 0.45 6.08 0.32 3.4e-9 Survival in pancreatic cancer; CRC trans rs61931739 0.500 rs11053282 chr12:34561151 T/C cg26384229 chr12:38710491 ALG10B 0.67 8.7 0.43 1.61e-16 Morning vs. evening chronotype; CRC cis rs1577917 1.000 rs12215903 chr6:86675028 C/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.52 -6.82 -0.35 4.4e-11 Response to antipsychotic treatment; CRC cis rs8062405 0.964 rs78613234 chr16:28839425 T/C cg08761264 chr16:28874980 SH2B1 -0.42 -5.63 -0.3 3.83e-8 Cognitive ability (multi-trait analysis);Cognitive ability; CRC cis rs13191362 1.000 rs35017019 chr6:162982581 A/G cg06582575 chr6:163149167 PACRG;PARK2 0.8 10.98 0.52 4.33e-24 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs10504229 0.775 rs72650876 chr8:58161638 G/A cg20607798 chr8:58055168 NA 0.47 5.78 0.3 1.76e-8 Developmental language disorder (linguistic errors); CRC cis rs589448 0.902 rs315131 chr12:69761839 T/G cg22834771 chr12:69754056 YEATS4 -0.56 -8.68 -0.43 1.93e-16 Cerebrospinal fluid biomarker levels; CRC cis rs7493 0.806 rs17876090 chr7:95053404 A/T cg20119798 chr7:94954144 PON1 -0.53 -6.61 -0.34 1.52e-10 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs875971 0.660 rs6460308 chr7:66084740 T/C cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.43 -6.34 -0.33 7.41e-10 Aortic root size; CRC cis rs6662572 0.737 rs4660893 chr1:46327532 T/C cg08644498 chr1:46502608 NA -0.45 -7.07 -0.36 9.42e-12 Blood protein levels; CRC cis rs2882667 0.931 rs10077896 chr5:138356756 G/A cg04439458 chr5:138467593 SIL1 -0.33 -5.92 -0.31 8.28e-9 Age-related hearing impairment (SNP x SNP interaction); CRC trans rs4927850 1.000 rs7627706 chr3:195753353 A/C cg16724585 chr3:197361211 NA -0.48 -7.08 -0.36 8.94e-12 Pancreatic cancer; CRC cis rs1799949 1.000 rs12944597 chr17:41187684 A/C cg25072359 chr17:41440525 NA 0.45 6.55 0.34 2.16e-10 Menopause (age at onset); CRC cis rs34375054 0.624 rs73233307 chr12:125675873 G/C cg06287003 chr12:125626642 AACS -0.58 -7.49 -0.38 6.42e-13 Post bronchodilator FEV1/FVC ratio; CRC trans rs8108034 1.000 rs39587 chr19:39806997 C/T cg26399773 chr5:74633655 HMGCR -0.55 -6.39 -0.33 5.81e-10 Lung adenocarcinoma; CRC cis rs10504073 0.584 rs11776843 chr8:49928449 C/T cg00325661 chr8:49890786 NA 0.62 11.23 0.53 5.31e-25 Blood metabolite ratios; CRC trans rs116095464 0.558 rs9312957 chr5:202194 C/T cg00938859 chr5:1591904 SDHAP3 0.63 6.01 0.31 4.82e-9 Breast cancer; CRC cis rs9649213 0.574 rs6979373 chr7:97961844 T/C cg00277769 chr7:97922759 BAIAP2L1 -0.6 -10.46 -0.5 2.77e-22 Prostate cancer (SNP x SNP interaction); CRC cis rs2645694 0.911 rs2703147 chr4:77831307 C/T cg18351406 chr4:77819688 ANKRD56 0.49 7.39 0.38 1.24e-12 Emphysema distribution in smoking; CRC cis rs9733 0.596 rs12072339 chr1:150686099 A/G cg17724175 chr1:150552817 MCL1 0.57 9.12 0.45 7.76e-18 Tonsillectomy; CRC cis rs2213920 0.679 rs10759786 chr9:118241188 A/G cg13918206 chr9:118159781 DEC1 0.55 5.63 0.3 3.83e-8 Docetaxel-induced peripheral neuropathy in metastatic castrate-resistant prostate cancer; CRC cis rs9584850 0.834 rs7339274 chr13:99120272 A/G cg07423050 chr13:99094983 FARP1 -0.45 -6.33 -0.33 8.13e-10 Neuroticism; CRC cis rs344364 0.511 rs1742463 chr16:1946110 A/G cg00046913 chr16:1877150 HAGH;FAHD1 -0.56 -5.92 -0.31 7.93e-9 Glomerular filtration rate in chronic kidney disease; CRC cis rs28829049 0.597 rs34219832 chr1:19502432 C/T cg13387374 chr1:19411106 UBR4 0.42 6.14 0.32 2.39e-9 QRS duration in Tripanosoma cruzi seropositivity; CRC cis rs2180341 0.889 rs9321074 chr6:127618019 G/A cg24812749 chr6:127587940 RNF146 0.94 13.67 0.6 5.36e-34 Breast cancer; CRC cis rs7945705 0.747 rs2568045 chr11:9004060 T/C cg14711859 chr11:8959438 ASCL3 0.37 6.21 0.32 1.59e-9 Hemoglobin concentration; CRC cis rs4713118 0.739 rs2893931 chr6:27748010 G/A cg06470822 chr6:28175283 NA 0.74 10.0 0.48 9.56e-21 Parkinson's disease; CRC cis rs12541635 0.833 rs4099936 chr8:107099297 G/A cg10147462 chr8:107024639 NA -0.39 -5.97 -0.31 6.01e-9 Age of smoking initiation; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg00694302 chr12:47609865 LOC100233209;FAM113B 0.45 6.81 0.35 4.63e-11 Liver disease severity in Alagille syndrome; CRC cis rs2652834 1.000 rs2729833 chr15:63397044 G/A cg05507819 chr15:63340323 TPM1 0.46 5.99 0.31 5.46e-9 HDL cholesterol; CRC cis rs208520 0.690 rs3843513 chr6:66836797 A/G cg07460842 chr6:66804631 NA -1.1 -14.99 -0.64 4.56e-39 Exhaled nitric oxide output; CRC cis rs10944 0.598 rs9293761 chr5:78290215 C/T cg13121490 chr5:78280331 ARSB -0.51 -6.99 -0.36 1.55e-11 Blood and toenail selenium levels; CRC cis rs1707322 1.000 rs4489497 chr1:46438698 C/T cg03146154 chr1:46216737 IPP 0.51 7.06 0.36 1.01e-11 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs12956009 0.583 rs919979 chr18:44902739 C/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.41 6.0 0.31 5.1e-9 Educational attainment (years of education); CRC cis rs734999 0.588 rs745367 chr1:2524457 T/C cg20673091 chr1:2541236 MMEL1 0.36 5.82 0.31 1.43e-8 Ulcerative colitis; CRC cis rs883565 0.740 rs7624734 chr3:39108503 G/A cg01426195 chr3:39028469 NA -0.54 -8.65 -0.43 2.36e-16 Handedness; CRC cis rs3858526 0.523 rs10769287 chr11:5884845 T/C cg13902645 chr11:5959945 NA -0.68 -10.04 -0.48 7.25e-21 DNA methylation (variation); CRC cis rs6500602 0.702 rs56895104 chr16:4548132 G/A cg08645402 chr16:4508243 NA 0.64 11.47 0.53 7.3e-26 Schizophrenia; CRC cis rs4664293 0.625 rs6760931 chr2:160559111 C/G cg08347373 chr2:160653686 CD302 0.39 6.53 0.34 2.44e-10 Monocyte percentage of white cells; CRC cis rs7618915 0.547 rs8906 chr3:52739520 T/C cg10802521 chr3:52805072 NEK4 -0.57 -8.53 -0.43 5.53e-16 Bipolar disorder; CRC cis rs7149337 1.000 rs4261445 chr14:51723540 G/A cg23942311 chr14:51606299 NA 0.64 11.09 0.52 1.76e-24 Cancer; CRC cis rs12893668 0.572 rs11540512 chr14:104147377 C/T cg24130564 chr14:104152367 KLC1 -0.43 -5.74 -0.3 2.19e-8 Reticulocyte count; CRC cis rs853679 0.760 rs2299029 chr6:28198831 G/A cg21251018 chr6:28226885 NKAPL 0.54 6.46 0.34 3.7e-10 Depression; CRC cis rs3771570 0.901 rs6757876 chr2:242245570 T/C cg21155796 chr2:242212141 HDLBP 0.58 6.95 0.36 2.02e-11 Prostate cancer; CRC cis rs6502050 0.835 rs8080625 chr17:80115447 G/A cg09264619 chr17:80180166 NA -0.35 -5.97 -0.31 5.98e-9 Life satisfaction; CRC cis rs12681288 0.862 rs2004701 chr8:1022287 A/G cg04851639 chr8:1020857 NA -0.36 -7.63 -0.39 2.49e-13 Schizophrenia; CRC cis rs4692589 1.000 rs11727880 chr4:170937467 C/T cg19918862 chr4:170955249 NA 0.39 6.4 0.33 5.33e-10 Anxiety disorder; CRC cis rs11122272 0.735 rs10489611 chr1:231517854 A/T cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.54 -8.09 -0.41 1.18e-14 Hemoglobin concentration; CRC cis rs7618915 0.547 rs4687636 chr3:52633929 G/A cg15147215 chr3:52552868 STAB1 -0.62 -10.22 -0.49 1.8e-21 Bipolar disorder; CRC cis rs951366 0.668 rs823154 chr1:205762406 C/T cg07167872 chr1:205819463 PM20D1 0.88 14.49 0.62 3.96e-37 Menarche (age at onset); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg05704155 chr1:10459140 PGD 0.38 6.1 0.32 2.93e-9 Liver disease severity in Alagille syndrome; CRC cis rs7647973 0.771 rs9865051 chr3:49166069 C/T cg07636037 chr3:49044803 WDR6 0.82 9.35 0.46 1.36e-18 Menarche (age at onset); CRC cis rs4665809 0.590 rs3806514 chr2:26466772 C/T cg04944784 chr2:26401820 FAM59B 0.87 11.85 0.55 3.24e-27 Gut microbiome composition (summer); CRC cis rs911555 0.755 rs12436729 chr14:103929889 G/C cg24130564 chr14:104152367 KLC1 0.44 5.96 0.31 6.54e-9 Intelligence (multi-trait analysis); CRC cis rs77956314 0.818 rs12296869 chr12:117431203 G/A cg02017074 chr12:117425053 FBXW8 -0.64 -6.91 -0.36 2.45e-11 Subcortical brain region volumes;Hippocampal volume; CRC cis rs9549260 0.592 rs9532588 chr13:41302913 G/A cg21288729 chr13:41239152 FOXO1 0.39 5.93 0.31 7.46e-9 Red blood cell count; CRC cis rs1153858 1.000 rs12909158 chr15:45621174 A/G cg10760299 chr15:45669010 GATM 0.51 8.11 0.41 1.03e-14 Homoarginine levels; CRC cis rs7731657 0.537 rs12516770 chr5:130222575 T/C cg08523029 chr5:130500466 HINT1 -0.47 -6.13 -0.32 2.45e-9 Fasting plasma glucose; CRC cis rs4285028 0.948 rs7640872 chr3:121697168 C/A cg11130432 chr3:121712080 ILDR1 -0.53 -6.88 -0.35 3.03e-11 Multiple sclerosis; CRC cis rs9911578 0.967 rs4076229 chr17:56937256 C/T cg12560992 chr17:57184187 TRIM37 0.92 16.91 0.68 1.29e-46 Intelligence (multi-trait analysis); CRC cis rs6570726 0.967 rs374728 chr6:145854598 T/A cg05347473 chr6:146136440 FBXO30 0.38 6.06 0.32 3.79e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs3736485 0.899 rs7183479 chr15:51942207 C/G cg08986416 chr15:51914746 DMXL2 -0.45 -6.46 -0.34 3.87e-10 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs6502050 0.835 rs8078950 chr17:80122327 T/G cg11859384 chr17:80120422 CCDC57 -0.36 -5.75 -0.3 2.06e-8 Life satisfaction; CRC cis rs7937682 0.824 rs539524 chr11:111477325 A/G cg19812747 chr11:111475976 SIK2 -0.57 -9.75 -0.47 7e-20 Primary sclerosing cholangitis; CRC cis rs7727544 0.836 rs10463892 chr5:131598705 T/C cg14196790 chr5:131705035 SLC22A5 0.31 5.62 0.3 4.1e-8 Blood metabolite levels; CRC cis rs763121 0.853 rs3827357 chr22:39079413 A/G cg06022373 chr22:39101656 GTPBP1 0.79 12.32 0.56 6.2e-29 Menopause (age at onset); CRC cis rs7786808 0.525 rs10253961 chr7:158194858 G/A cg01191920 chr7:158217561 PTPRN2 0.58 9.42 0.46 8.53e-19 Obesity-related traits; CRC cis rs9814567 1.000 rs7432268 chr3:134242051 T/A cg06541857 chr3:134203789 ANAPC13;CEP63 -0.4 -6.02 -0.31 4.76e-9 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs2070997 0.816 rs1800609 chr9:133731184 A/G cg01000188 chr9:133769184 QRFP 0.51 5.67 0.3 3.1e-8 Response to amphetamines; CRC cis rs2361718 0.522 rs11867921 chr17:78121170 G/T cg20811857 chr17:78079795 GAA -0.49 -6.11 -0.32 2.81e-9 Yeast infection; CRC cis rs4713118 0.786 rs200503 chr6:27785882 A/G cg12273811 chr6:28175739 NA 0.45 5.63 0.3 3.81e-8 Parkinson's disease; CRC cis rs9443645 0.835 rs1044309 chr6:79646575 A/G cg05283184 chr6:79620031 NA -0.57 -8.95 -0.44 2.69e-17 Intelligence (multi-trait analysis); CRC cis rs9916302 0.851 rs11657899 chr17:37626963 G/A cg07936489 chr17:37558343 FBXL20 -0.84 -13.1 -0.59 7.38e-32 Glomerular filtration rate (creatinine); CRC trans rs9951602 0.512 rs12458828 chr18:76648522 C/T cg02800362 chr5:177631904 HNRNPAB -0.76 -10.61 -0.5 8.13e-23 Obesity-related traits; CRC cis rs12477438 0.765 rs6740054 chr2:99576631 C/T cg14399236 chr2:99771627 LIPT1;TSGA10 -0.59 -8.2 -0.41 5.6e-15 Chronic sinus infection; CRC cis rs10751667 0.714 rs7395879 chr11:963855 G/C cg01483505 chr11:975446 AP2A2 0.46 7.66 0.39 2.11e-13 Alzheimer's disease (late onset); CRC cis rs2361718 0.603 rs12951255 chr17:78085597 A/G cg21320455 chr17:78086503 GAA -0.36 -6.09 -0.32 3.09e-9 Yeast infection; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg09188322 chr1:113258477 PPM1J 0.43 5.99 0.31 5.52e-9 Response to antipsychotic treatment; CRC cis rs1552244 0.938 rs66915020 chr3:10110174 A/G cg10729496 chr3:10149963 C3orf24 0.52 6.93 0.36 2.21e-11 Alzheimer's disease; CRC cis rs7811142 0.943 rs3900792 chr7:100004577 C/G cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.95 13.23 0.59 2.47e-32 Platelet count; CRC cis rs10504229 0.593 rs79615400 chr8:57988740 C/T cg08219700 chr8:58056026 NA 0.54 6.15 0.32 2.27e-9 Developmental language disorder (linguistic errors); CRC cis rs11148252 0.740 rs9536052 chr13:52960709 C/G cg12458913 chr13:53173898 NA -0.47 -7.1 -0.36 7.64e-12 Lewy body disease; CRC cis rs654950 0.776 rs2759252 chr1:42021854 G/A cg06885757 chr1:42089581 HIVEP3 -0.5 -8.34 -0.42 2.08e-15 Airway imaging phenotypes; CRC trans rs6703335 0.870 rs10803142 chr1:243598234 A/G cg24839693 chr17:43212892 ACBD4 0.44 6.11 0.32 2.76e-9 Schizophrenia;Schizophrenia, schizoaffective disorder or bipolar disorder; CRC cis rs9522267 0.966 rs9515443 chr13:112197387 T/C cg10483660 chr13:112241077 NA -0.36 -6.15 -0.32 2.26e-9 Hepatitis; CRC cis rs4363385 0.747 rs885096 chr1:152971313 T/C cg25856811 chr1:152973957 SPRR3 -0.26 -7.24 -0.37 3.29e-12 Inflammatory skin disease; CRC cis rs55823223 0.564 rs12103594 chr17:73855279 C/T cg14829360 chr17:73884958 NA -0.43 -6.67 -0.34 1.11e-10 Psoriasis; CRC cis rs4803480 0.573 rs2302188 chr19:42085873 C/T cg08478046 chr19:42093086 CEACAM21 0.3 6.48 0.34 3.27e-10 Schizophrenia; CRC cis rs11971779 0.715 rs6943973 chr7:139029893 G/C cg07862535 chr7:139043722 LUC7L2 0.59 7.58 0.39 3.47e-13 Diisocyanate-induced asthma; CRC cis rs2115630 1.000 rs1030863 chr15:85282635 C/T cg11189052 chr15:85197271 WDR73 -0.61 -9.91 -0.48 1.97e-20 P wave terminal force; CRC cis rs3751196 0.808 rs117214801 chr12:104215022 G/A cg02344784 chr12:104178138 NT5DC3 0.71 7.54 0.38 4.58e-13 Sense of smell; CRC cis rs6963495 0.818 rs73190200 chr7:105165856 T/C cg02135003 chr7:105160482 PUS7 -0.91 -12.41 -0.56 2.87e-29 Bipolar disorder (body mass index interaction); CRC trans rs1005277 0.579 rs1780137 chr10:38501475 C/G cg11292332 chr7:45801988 SEPT13 -0.38 -6.75 -0.35 6.61e-11 Extrinsic epigenetic age acceleration; CRC cis rs9527 0.590 rs7074395 chr10:104844928 A/C cg04362960 chr10:104952993 NT5C2 -0.59 -8.44 -0.42 1.04e-15 Arsenic metabolism; CRC cis rs7259376 0.936 rs12151261 chr19:22587929 C/T cg02657401 chr19:22469223 NA 0.31 6.72 0.35 8.02e-11 Menopause (age at onset); CRC trans rs7615952 0.932 rs6438948 chr3:125650045 A/T cg21747405 chr11:67723411 NA 0.44 6.51 0.34 2.8e-10 Blood pressure (smoking interaction); CRC cis rs3750965 0.839 rs921670 chr11:68871639 C/T cg06818126 chr11:68850279 TPCN2 -0.4 -5.64 -0.3 3.65e-8 Hair color; CRC cis rs12142240 0.698 rs7515598 chr1:46818479 C/T cg14993813 chr1:46806288 NSUN4 -0.48 -6.15 -0.32 2.24e-9 Menopause (age at onset); CRC trans rs7395662 0.889 rs11039972 chr11:48759252 A/G cg21153622 chr11:89784906 NA 0.46 7.39 0.38 1.26e-12 HDL cholesterol; CRC cis rs7584330 0.868 rs6760842 chr2:238398165 C/T cg16989719 chr2:238392110 NA 0.44 8.08 0.41 1.21e-14 Prostate cancer; CRC cis rs644799 0.544 rs1527450 chr11:95467777 G/T cg03916912 chr11:95522834 CEP57;FAM76B 0.68 10.44 0.5 3.2e-22 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs17666538 0.535 rs1669658 chr8:607380 A/G cg26554054 chr8:600488 NA 0.59 5.7 0.3 2.66e-8 IgG glycosylation; CRC cis rs1129187 0.935 rs4987173 chr6:42931224 G/A cg09436375 chr6:42928200 GNMT -0.32 -5.89 -0.31 9.29e-9 Alzheimer's disease in APOE e4+ carriers; CRC cis rs11676348 0.818 rs7423433 chr2:218985084 G/A cg00012203 chr2:219082015 ARPC2 -0.43 -6.3 -0.33 9.47e-10 Ulcerative colitis; CRC trans rs3807766 0.581 rs6954104 chr7:77693258 C/T cg21115120 chr5:157158441 THG1L -0.46 -6.35 -0.33 7.07e-10 3-hydroxypropylmercapturic acid levels in smokers; CRC cis rs7119 0.717 rs35268067 chr15:77753688 C/G cg17802220 chr15:77601643 NA -0.46 -6.57 -0.34 1.99e-10 Type 2 diabetes; CRC cis rs2228479 0.850 rs11076624 chr16:89855749 T/C cg06558623 chr16:89946397 TCF25 1.16 11.41 0.53 1.27e-25 Skin colour saturation; CRC cis rs9287719 0.967 rs6719701 chr2:10748283 G/A cg00105475 chr2:10696890 NA 0.45 7.17 0.37 4.87e-12 Prostate cancer; CRC cis rs897984 0.542 rs7197717 chr16:31083075 A/C cg00531865 chr16:30841666 NA -0.44 -6.37 -0.33 6.54e-10 Dementia with Lewy bodies; CRC cis rs9462846 0.881 rs34498470 chr6:42879551 C/T cg02353165 chr6:42928485 GNMT 0.57 7.48 0.38 6.83e-13 Blood protein levels; CRC cis rs7727544 0.684 rs270602 chr5:131656700 T/C cg07395648 chr5:131743802 NA -0.4 -6.19 -0.32 1.79e-9 Blood metabolite levels; CRC cis rs6963495 0.769 rs117986187 chr7:105167311 G/A cg02135003 chr7:105160482 PUS7 -0.91 -12.41 -0.56 2.87e-29 Bipolar disorder (body mass index interaction); CRC cis rs3806843 0.607 rs246060 chr5:140324749 T/C cg19875535 chr5:140030758 IK 0.39 6.02 0.31 4.67e-9 Depressive symptoms (multi-trait analysis); CRC cis rs3091242 1.000 rs9689 chr1:25688276 A/G cg20684491 chr1:25596433 NA 0.43 7.91 0.4 3.97e-14 Erythrocyte sedimentation rate; CRC cis rs1801251 0.928 rs4458205 chr2:233557646 C/T cg25237894 chr2:233734115 C2orf82 0.53 8.45 0.42 9.770000000000001e-16 Coronary artery disease; CRC cis rs7552404 0.627 rs12127049 chr1:76353248 G/A cg22875332 chr1:76189707 ACADM 0.63 7.68 0.39 1.88e-13 Blood metabolite levels;Acylcarnitine levels; CRC cis rs780096 0.526 rs780112 chr2:27665361 C/G cg17158414 chr2:27665306 KRTCAP3 -0.31 -6.74 -0.35 7.01e-11 Total body bone mineral density; CRC cis rs10992471 0.603 rs7873397 chr9:95205928 G/C cg14631576 chr9:95140430 CENPP -0.4 -7.13 -0.37 6.48e-12 Visceral adipose tissue/subcutaneous adipose tissue ratio; CRC cis rs7493 0.950 rs17880101 chr7:95031457 A/T cg17330251 chr7:94953956 PON1 -0.58 -7.45 -0.38 8.55e-13 Yu-Zhi constitution type in type 2 diabetes; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg08240007 chr2:220407822 CHPF;TMEM198 0.46 6.79 0.35 5.15e-11 Intelligence (multi-trait analysis); CRC cis rs1707322 1.000 rs4660905 chr1:46461587 C/T cg06784218 chr1:46089804 CCDC17 -0.51 -9.09 -0.45 9.77e-18 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs7618915 0.547 rs4687638 chr3:52651966 A/C cg05573699 chr3:52720067 GNL3;PBRM1 -0.44 -6.22 -0.32 1.47e-9 Bipolar disorder; CRC cis rs10504229 0.728 rs72650858 chr8:58152832 G/A cg21724239 chr8:58056113 NA 0.62 8.38 0.42 1.51e-15 Developmental language disorder (linguistic errors); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg16932098 chr10:97321215 SORBS1 0.44 6.53 0.34 2.46e-10 Intelligence (multi-trait analysis); CRC cis rs823143 0.570 rs1361754 chr1:205801872 C/T cg11965913 chr1:205819406 PM20D1 -0.67 -11.13 -0.52 1.19e-24 Monocyte percentage of white cells; CRC cis rs9303401 0.659 rs17222523 chr17:56620501 A/G cg10487724 chr17:56770010 TEX14;RAD51C 0.79 9.6 0.47 2.05e-19 Cognitive test performance; CRC cis rs8072100 0.713 rs2136750 chr17:45456100 A/G cg08085267 chr17:45401833 C17orf57 -0.59 -8.92 -0.44 3.27e-17 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs344364 0.511 rs2982455 chr16:1950498 T/G cg09830162 chr16:1889614 FAHD1;C16orf73 -0.77 -9.32 -0.46 1.72e-18 Glomerular filtration rate in chronic kidney disease; CRC cis rs2046867 0.661 rs9861834 chr3:72909272 C/T cg25664220 chr3:72788482 NA -0.38 -5.81 -0.31 1.46e-8 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; CRC cis rs881375 0.678 rs10760130 chr9:123701990 G/A cg09586646 chr9:123605570 PSMD5;LOC253039 0.44 6.63 0.34 1.4e-10 Rheumatoid arthritis; CRC trans rs12599106 0.818 rs17723574 chr16:34602945 C/G cg07332563 chr6:291687 DUSP22 -0.47 -6.77 -0.35 5.76e-11 Menopause (age at onset); CRC cis rs2996428 0.667 rs16824230 chr1:3766240 A/G cg13057898 chr1:3703894 LRRC47 0.46 6.56 0.34 2.05e-10 Red cell distribution width; CRC cis rs12325245 0.536 rs34676074 chr16:58549321 G/C cg26666090 chr16:58549219 SETD6 1.01 6.67 0.35 1.06e-10 Schizophrenia; CRC cis rs11212617 0.967 rs11605442 chr11:108077857 G/A cg14761454 chr11:108092087 ATM;NPAT 0.42 6.46 0.34 3.72e-10 Response to metformin in type 2 diabetes (glycemic); CRC cis rs2282802 0.635 rs199152 chr5:139539235 C/T cg26211634 chr5:139558579 C5orf32 -0.37 -6.4 -0.33 5.28e-10 Intelligence (multi-trait analysis); CRC cis rs1555895 0.576 rs12413763 chr10:849454 A/G cg10556349 chr10:835070 NA -0.36 -6.84 -0.35 3.92e-11 Survival in rectal cancer; CRC cis rs4243830 0.850 rs4434862 chr1:6602241 C/A cg22792644 chr1:6614718 TAS1R1;NOL9 -0.8 -9.67 -0.47 1.21e-19 Body mass index; CRC cis rs12701220 0.655 rs10215292 chr7:1135263 A/G cg00990874 chr7:1149470 C7orf50 -0.68 -8.92 -0.44 3.28e-17 Bronchopulmonary dysplasia; CRC cis rs9894429 0.646 rs6565609 chr17:79592267 G/A cg21028142 chr17:79581711 NPLOC4 0.35 7.23 0.37 3.33e-12 Eye color traits; CRC cis rs6546324 0.625 rs2861701 chr2:67855980 T/G cg15745817 chr2:67799979 NA -0.57 -9.88 -0.48 2.49e-20 Endometriosis; CRC trans rs9858542 0.953 rs6446264 chr3:49417243 C/A cg21665057 chr3:196295764 WDR53;FBXO45 -0.62 -8.52 -0.43 5.85e-16 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC trans rs7647973 0.710 rs7629322 chr3:49621994 C/T cg21659725 chr3:3221576 CRBN -0.7 -7.78 -0.39 9.74e-14 Menarche (age at onset); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg00539716 chr2:48541921 FOXN2 0.43 6.44 0.33 4.11e-10 Intelligence (multi-trait analysis); CRC cis rs2629540 0.737 rs10901821 chr10:126480556 T/C cg08799069 chr10:126477246 METTL10 -0.55 -7.81 -0.4 7.8e-14 Cocaine dependence; CRC cis rs4975616 0.869 rs31484 chr5:1337906 A/T cg06550200 chr5:1325588 CLPTM1L -0.72 -11.33 -0.53 2.38e-25 Lung cancer; CRC cis rs769267 0.930 rs10402451 chr19:19608537 A/G cg03709012 chr19:19516395 GATAD2A 0.73 11.3 0.53 3.03e-25 Tonsillectomy; CRC trans rs7267979 1.000 rs4815424 chr20:25390284 T/C cg17903999 chr18:56338584 MALT1 0.4 6.63 0.34 1.37e-10 Liver enzyme levels (alkaline phosphatase); CRC cis rs12142240 0.698 rs10158572 chr1:46822440 G/T cg00530320 chr1:46809349 NSUN4 0.59 8.03 0.41 1.69e-14 Menopause (age at onset); CRC cis rs873946 0.586 rs12774727 chr10:134569910 T/C cg06453172 chr10:134556979 INPP5A -0.69 -8.22 -0.41 4.68e-15 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CRC cis rs853679 0.517 rs9393894 chr6:28112562 A/G cg02631126 chr6:28058918 ZSCAN12L1 0.29 5.91 0.31 8.38e-9 Depression; CRC cis rs2243480 1.000 rs11538349 chr7:65421871 C/T cg12463550 chr7:65579703 CRCP 0.62 5.99 0.31 5.58e-9 Diabetic kidney disease; CRC cis rs7264396 0.563 rs6060566 chr20:34288226 T/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.49 -7.01 -0.36 1.39e-11 Total cholesterol levels; CRC cis rs13191362 1.000 rs67042566 chr6:163006541 A/T cg23758597 chr6:163146217 PARK2 -0.55 -6.13 -0.32 2.54e-9 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs561341 0.941 rs501773 chr17:30314435 T/G cg00745463 chr17:30367425 LRRC37B -0.75 -9.07 -0.45 1.08e-17 Hip circumference adjusted for BMI; CRC cis rs2976388 0.647 rs2585136 chr8:143812141 A/G cg12516270 chr8:143859308 LYNX1 0.43 7.44 0.38 9.08e-13 Urinary tract infection frequency; CRC cis rs6570726 0.764 rs9403733 chr6:145912311 A/C cg23711669 chr6:146136114 FBXO30 0.76 13.18 0.59 3.84e-32 Lobe attachment (rater-scored or self-reported); CRC cis rs208520 0.754 rs851593 chr6:66875783 C/T cg07460842 chr6:66804631 NA 1.04 14.39 0.62 9.58e-37 Exhaled nitric oxide output; CRC cis rs9467773 0.595 rs4320356 chr6:26423560 C/T cg09904177 chr6:26538194 HMGN4 -0.44 -6.18 -0.32 1.89e-9 Intelligence (multi-trait analysis); CRC cis rs1046896 0.520 rs9895409 chr17:80902719 C/T cg08200770 chr17:80723486 TBCD -0.45 -6.85 -0.35 3.66e-11 Glycated hemoglobin levels; CRC cis rs6502050 0.761 rs62078754 chr17:80058666 C/T cg02741985 chr17:80059408 CCDC57 -0.45 -7.15 -0.37 5.7e-12 Life satisfaction; CRC cis rs17711722 0.701 rs781143 chr7:65439879 G/C cg02869306 chr7:64672164 INTS4L1 -0.35 -5.79 -0.3 1.66e-8 Calcium levels; CRC cis rs9921222 0.502 rs28461430 chr16:369562 G/A cg08923669 chr16:420230 MRPL28 -0.59 -7.5 -0.38 6.1e-13 Bone mineral density (spine);Bone mineral density; CRC cis rs6988636 1.000 rs28537152 chr8:124189071 T/C cg27053337 chr8:124217698 FAM83A 0.46 6.99 0.36 1.58e-11 Urinary uromodulin levels; CRC cis rs11971779 0.715 rs7781459 chr7:139093882 A/G cg23387468 chr7:139079360 LUC7L2 0.41 7.04 0.36 1.14e-11 Diisocyanate-induced asthma; CRC cis rs875971 0.755 rs10228885 chr7:65780529 C/G cg11764359 chr7:65958608 NA -0.59 -8.74 -0.43 1.2e-16 Aortic root size; CRC cis rs172166 0.694 rs1631552 chr6:28089699 C/A cg15786705 chr6:28176104 NA 0.62 8.95 0.44 2.67e-17 Cardiac Troponin-T levels; CRC cis rs17095355 1.000 rs11194923 chr10:111695762 A/G cg00817464 chr10:111662876 XPNPEP1 -0.6 -8.06 -0.41 1.43e-14 Biliary atresia; CRC cis rs2898681 0.581 rs11938140 chr4:53678057 T/A cg00338735 chr4:53728038 RASL11B 0.39 5.92 0.31 8.08e-9 Optic nerve measurement (cup area); CRC cis rs3820068 0.581 rs72645893 chr1:15930943 C/G cg24675056 chr1:15929824 NA 0.49 6.77 0.35 5.87e-11 Systolic blood pressure; CRC cis rs9487051 0.872 rs1320612 chr6:109611990 C/A cg01475377 chr6:109611718 NA -0.49 -9.15 -0.45 5.96e-18 Reticulocyte fraction of red cells; CRC cis rs8114671 0.562 rs7266550 chr20:33495510 C/T cg07148914 chr20:33460835 GGT7 0.39 6.41 0.33 4.92e-10 Height; CRC cis rs6500395 0.962 rs1872652 chr16:48642928 C/A cg04672837 chr16:48644449 N4BP1 0.42 5.79 0.3 1.63e-8 Response to tocilizumab in rheumatoid arthritis; CRC cis rs2836974 0.681 rs8128827 chr21:40710547 C/T cg06238570 chr21:40685208 BRWD1 0.71 9.26 0.45 2.78e-18 Cognitive function; CRC cis rs9902453 0.904 rs4994353 chr17:28386280 T/A cg26525008 chr17:28256777 EFCAB5;SSH2 -0.6 -8.88 -0.44 4.41e-17 Coffee consumption (cups per day); CRC cis rs6840360 0.615 rs7669465 chr4:152609289 C/T cg09659197 chr4:152720779 NA 0.39 7.73 0.39 1.28e-13 Intelligence (multi-trait analysis); CRC cis rs9914988 0.887 rs11080072 chr17:27081160 G/T cg16670446 chr17:27188758 MIR451;MIR144 0.6 10.35 0.5 6.34e-22 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC trans rs1005277 0.579 rs1780138 chr10:38501654 A/G cg23533926 chr12:111358616 MYL2 -0.56 -8.67 -0.43 1.97e-16 Extrinsic epigenetic age acceleration; CRC cis rs6840360 0.550 rs7675818 chr4:152690777 C/G cg09659197 chr4:152720779 NA 0.41 8.62 0.43 2.82e-16 Intelligence (multi-trait analysis); CRC trans rs6951245 1.000 rs76833820 chr7:1070278 A/T cg13565492 chr6:43139072 SRF -0.71 -7.31 -0.37 2.04e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs3784262 1.000 rs4646593 chr15:58302467 A/G cg12031962 chr15:58353849 ALDH1A2 -0.34 -5.93 -0.31 7.53e-9 Barrett's esophagus;Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined); CRC cis rs4731207 0.698 rs10954048 chr7:124533740 C/T cg23710748 chr7:124431027 NA -0.38 -6.06 -0.32 3.65e-9 Cutaneous malignant melanoma; CRC cis rs34779708 0.931 rs12268745 chr10:35305989 C/G cg03585969 chr10:35415529 CREM 0.57 7.65 0.39 2.26e-13 Inflammatory bowel disease;Crohn's disease; CRC cis rs9894429 0.646 rs7406522 chr17:79615396 G/T cg13777783 chr17:79615861 NA -0.3 -5.63 -0.3 3.79e-8 Eye color traits; CRC cis rs1878931 0.513 rs35160989 chr16:3405506 G/A cg26668626 chr16:3451006 ZNF174;ZNF434 0.82 13.04 0.58 1.27e-31 Body mass index (adult); CRC cis rs875971 0.545 rs35459055 chr7:65944386 G/A cg11764359 chr7:65958608 NA 0.45 5.74 0.3 2.1e-8 Aortic root size; CRC cis rs798554 0.644 rs7783400 chr7:2894434 A/C cg13628971 chr7:2884303 GNA12 -0.55 -7.86 -0.4 5.47e-14 Height; CRC cis rs75920871 0.588 rs1940626 chr11:116828121 T/C cg20608306 chr11:116969690 SIK3 -0.31 -5.67 -0.3 3.13e-8 Subjective well-being; CRC cis rs8062405 0.540 rs151226 chr16:28549823 A/C cg05139728 chr16:28306816 SBK1 -0.32 -5.83 -0.31 1.32e-8 Cognitive ability (multi-trait analysis);Cognitive ability; CRC cis rs10197940 0.578 rs6718372 chr2:152345871 C/G cg06191203 chr2:152266755 RIF1 -0.46 -6.51 -0.34 2.83e-10 Lung cancer; CRC cis rs4713118 0.662 rs13218430 chr6:28029837 T/C cg15786705 chr6:28176104 NA 0.69 9.22 0.45 3.53e-18 Parkinson's disease; CRC cis rs11098499 0.954 rs6820115 chr4:120398182 T/C cg24375607 chr4:120327624 NA 0.44 6.84 0.35 3.83e-11 Corneal astigmatism; CRC cis rs853679 0.517 rs3757185 chr6:28107776 T/A cg02683197 chr6:28174875 NA 0.85 10.52 0.5 1.71e-22 Depression; CRC cis rs4423214 0.592 rs1790349 chr11:71142350 A/G cg05163923 chr11:71159392 DHCR7 -0.54 -5.78 -0.3 1.69e-8 Vitamin D levels; CRC cis rs6424115 0.729 rs561733 chr1:24049595 T/G cg10978503 chr1:24200527 CNR2 0.44 7.43 0.38 9.38e-13 Immature fraction of reticulocytes; CRC cis rs2710642 0.962 rs1828398 chr2:63034870 A/G cg17519650 chr2:63277830 OTX1 -0.43 -6.15 -0.32 2.29e-9 LDL cholesterol levels;LDL cholesterol; CRC cis rs72945132 0.882 rs55915603 chr11:70210067 G/T cg14191688 chr11:70257035 CTTN 0.45 6.05 0.32 3.99e-9 Coronary artery disease; CRC cis rs4268898 0.662 rs2303292 chr2:24432138 C/T cg06627628 chr2:24431161 ITSN2 -0.85 -11.58 -0.54 3.01e-26 Asthma; CRC cis rs4523957 0.579 rs4790883 chr17:2087605 T/C cg16513277 chr17:2031491 SMG6 -0.58 -9.76 -0.47 6.2e-20 Autism spectrum disorder or schizophrenia;Schizophrenia; CRC cis rs972578 0.811 rs2284091 chr22:43271504 G/T cg01576275 chr22:43409880 NA -0.4 -6.21 -0.32 1.57e-9 Mean platelet volume; CRC trans rs7824557 1.000 rs7824557 chr8:11104111 C/T cg06636001 chr8:8085503 FLJ10661 -0.46 -6.59 -0.34 1.79e-10 Retinal vascular caliber; CRC cis rs798554 0.797 rs798488 chr7:2802522 T/C cg19717773 chr7:2847554 GNA12 -0.47 -6.7 -0.35 8.97e-11 Height; CRC cis rs7267979 0.844 rs6076343 chr20:25376663 C/T cg24626310 chr20:25276739 ABHD12;PYGB -0.34 -5.75 -0.3 2.02e-8 Liver enzyme levels (alkaline phosphatase); CRC cis rs9486719 1.000 rs3798289 chr6:97023632 T/C cg06623918 chr6:96969491 KIAA0776 -0.82 -9.53 -0.47 3.58e-19 Migraine;Coronary artery disease; CRC cis rs6502050 0.777 rs4625783 chr17:80086395 T/C cg25804541 chr17:80189381 SLC16A3 0.31 5.9 0.31 8.92e-9 Life satisfaction; CRC cis rs478222 1.000 rs567359 chr2:25304574 C/T cg22495460 chr2:25135724 ADCY3 -0.41 -6.09 -0.32 3.12e-9 Type 1 diabetes; CRC cis rs9398803 0.865 rs1538172 chr6:126748493 A/G cg19875578 chr6:126661172 C6orf173 0.42 5.83 0.31 1.32e-8 Male-pattern baldness; CRC cis rs7927592 0.956 rs7106259 chr11:68298512 T/G cg01657329 chr11:68192670 LRP5 -0.47 -6.82 -0.35 4.36e-11 Total body bone mineral density; CRC cis rs10504229 0.683 rs16921814 chr8:58107421 A/T cg02725872 chr8:58115012 NA -0.61 -10.07 -0.49 5.73e-21 Developmental language disorder (linguistic errors); CRC cis rs11971779 0.648 rs66463279 chr7:139118661 A/G cg07862535 chr7:139043722 LUC7L2 0.73 8.98 0.44 2.2e-17 Diisocyanate-induced asthma; CRC cis rs3823572 0.564 rs2971983 chr7:133652537 A/G cg03336402 chr7:133662267 EXOC4 -0.67 -10.62 -0.51 7.59e-23 Intelligence (multi-trait analysis); CRC trans rs9858542 0.953 rs67216675 chr3:49493151 G/T cg21665057 chr3:196295764 WDR53;FBXO45 -0.63 -8.63 -0.43 2.58e-16 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs9611565 0.729 rs4822027 chr22:41786227 G/A cg06634786 chr22:41940651 POLR3H -0.69 -7.86 -0.4 5.41e-14 Vitiligo; CRC cis rs172166 0.538 rs1150686 chr6:28161271 T/G cg25164649 chr6:28176230 NA 0.47 6.93 0.36 2.17e-11 Cardiac Troponin-T levels; CRC cis rs4925386 0.840 rs8124907 chr20:60913127 A/G cg24112000 chr20:60950667 NA -0.49 -7.7 -0.39 1.58e-13 Colorectal cancer;Colorectal cancer (SNP x SNP interaction); CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg03786933 chr16:69760418 NQO1 -0.4 -6.21 -0.32 1.62e-9 Myopia (pathological); CRC trans rs1728785 1.000 rs1170436 chr16:68607486 T/A cg04657470 chr2:198365150 HSPE1;HSPD1 0.59 6.98 0.36 1.59e-11 Ulcerative colitis; CRC cis rs11122272 0.735 rs2486737 chr1:231520523 T/C cg06096015 chr1:231504339 EGLN1 0.4 5.94 0.31 7.17e-9 Hemoglobin concentration; CRC cis rs2243480 1.000 rs56985706 chr7:65394562 C/T cg12463550 chr7:65579703 CRCP 0.63 6.04 0.32 4.17e-9 Diabetic kidney disease; CRC cis rs2404602 0.692 rs2117369 chr15:76748861 A/T cg03037974 chr15:76606532 NA 0.75 13.64 0.6 6.96e-34 Blood metabolite levels; CRC cis rs11191205 0.644 rs3095791 chr10:103383836 T/C cg15320455 chr10:103880129 LDB1 0.55 6.09 0.32 3.12e-9 Intelligence (multi-trait analysis); CRC cis rs4819052 0.807 rs28715237 chr21:46673768 C/G cg11663144 chr21:46675770 NA -0.86 -14.97 -0.64 5.18e-39 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs713477 1.000 rs10134905 chr14:55911792 G/A cg13175173 chr14:55914753 NA -0.52 -9.74 -0.47 7.24e-20 Pediatric bone mineral content (femoral neck); CRC cis rs7829975 0.846 rs6601724 chr8:8544872 C/T cg06636001 chr8:8085503 FLJ10661 -0.59 -9.71 -0.47 9.33e-20 Mood instability; CRC cis rs1387259 0.839 rs7487682 chr12:48579665 A/C cg24011408 chr12:48396354 COL2A1 -0.42 -6.13 -0.32 2.46e-9 Obstructive sleep apnea trait (apnea hypopnea index); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg12963312 chr6:52441723 TRAM2 0.44 6.32 0.33 8.62e-10 Response to antipsychotic treatment; CRC cis rs4332037 0.539 rs55773130 chr7:2070554 T/C cg02421172 chr7:1938701 MAD1L1 0.42 5.62 0.3 4.11e-8 Bipolar disorder; CRC cis rs6570726 0.935 rs12663211 chr6:145818427 G/A cg23711669 chr6:146136114 FBXO30 0.68 12.16 0.56 2.33e-28 Lobe attachment (rater-scored or self-reported); CRC cis rs853679 0.517 rs9295759 chr6:28124469 C/T cg15845792 chr6:28175446 NA 1.04 13.89 0.61 7.67e-35 Depression; CRC cis rs2233152 0.656 rs2287691 chr19:41286163 C/G cg21869046 chr19:41225005 ITPKC 0.41 6.4 0.33 5.25e-10 Kawasaki disease; CRC cis rs7618501 0.633 rs11925192 chr3:50038664 G/A cg24308560 chr3:49941425 MST1R -0.53 -8.78 -0.44 9.28e-17 Intelligence (multi-trait analysis); CRC cis rs4285028 0.747 rs3732410 chr3:121415720 T/C cg20356878 chr3:121714668 ILDR1 -0.43 -6.06 -0.32 3.83e-9 Multiple sclerosis; CRC cis rs9322193 0.923 rs10782318 chr6:150075273 A/G cg07701084 chr6:150067640 NUP43 0.56 7.74 0.39 1.21e-13 Lung cancer; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg13641043 chr17:43198610 PLCD3 0.22 6.16 0.32 2.15e-9 Liver disease severity in Alagille syndrome; CRC cis rs7811142 0.943 rs28660238 chr7:100023308 C/T cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.14 17.74 0.7 7.11e-50 Platelet count; CRC cis rs531930 0.587 rs332611 chr6:124713527 C/T cg22366943 chr6:124882293 NKAIN2 -0.44 -6.6 -0.34 1.69e-10 Celiac disease; CRC cis rs2354432 0.607 rs894471 chr1:146687913 A/G cg25205988 chr1:146714368 CHD1L -0.9 -8.1 -0.41 1.07e-14 Mitochondrial DNA levels; CRC cis rs2760061 0.598 rs605410 chr1:228116281 A/G cg02753203 chr1:228287806 NA -0.61 -9.19 -0.45 4.71e-18 Diastolic blood pressure; CRC cis rs2976388 1.000 rs2976392 chr8:143762932 G/A cg24046110 chr8:143859143 LYNX1 -0.35 -6.01 -0.31 4.96e-9 Urinary tract infection frequency; CRC cis rs611744 0.647 rs1448150 chr8:109276161 T/C cg18478394 chr8:109455254 TTC35 0.38 5.82 0.31 1.38e-8 Dupuytren's disease; CRC cis rs4665809 0.878 rs4665826 chr2:26367503 A/T cg25036284 chr2:26402008 FAM59B 0.52 6.24 0.33 1.36e-9 Gut microbiome composition (summer); CRC cis rs10905065 0.610 rs72774056 chr10:5737065 C/T cg11519256 chr10:5708881 ASB13 -0.42 -5.88 -0.31 9.88e-9 Menopause (age at onset); CRC cis rs8016982 0.633 rs8015423 chr14:81719357 C/T cg01989461 chr14:81687754 GTF2A1 0.63 10.28 0.49 1.11e-21 Schizophrenia; CRC trans rs35110281 0.607 rs4819212 chr21:44977455 G/A cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.47 7.54 0.38 4.61e-13 Mean corpuscular volume; CRC cis rs75920871 0.588 rs4938321 chr11:116852507 C/T cg20608306 chr11:116969690 SIK3 -0.31 -5.74 -0.3 2.13e-8 Subjective well-being; CRC trans rs11026407 0.967 rs7127246 chr11:22060228 C/G cg04392234 chr4:74608458 IL8 -0.55 -6.01 -0.31 4.82e-9 Plasma thyroid-stimulating hormone levels; CRC trans rs656319 0.674 rs1484639 chr8:9983224 T/G cg06636001 chr8:8085503 FLJ10661 0.45 6.42 0.33 4.85e-10 Myopia (pathological); CRC cis rs2836974 0.644 rs2836986 chr21:40702136 A/C cg06238570 chr21:40685208 BRWD1 -0.83 -12.97 -0.58 2.42e-31 Cognitive function; CRC cis rs938554 0.868 rs734553 chr4:9923004 G/T cg00071950 chr4:10020882 SLC2A9 0.41 5.71 0.3 2.59e-8 Blood metabolite levels; CRC trans rs61931739 0.500 rs11053251 chr12:34520743 A/G cg13010199 chr12:38710504 ALG10B 0.46 6.6 0.34 1.67e-10 Morning vs. evening chronotype; CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg17783671 chr19:59070436 UBE2M;LOC100131691 0.38 6.17 0.32 2.05e-9 Obesity-related traits; CRC cis rs11190604 1.000 rs2495747 chr10:102328247 C/T cg16342193 chr10:102329863 NA -0.35 -5.9 -0.31 9.06e-9 Palmitoleic acid (16:1n-7) levels; CRC cis rs4563143 0.675 rs55976444 chr19:29265214 G/C cg12756686 chr19:29218302 NA 0.6 8.99 0.44 2.04e-17 Methadone dose in opioid dependence; CRC cis rs71386933 0.509 rs34400689 chr16:72003454 T/G cg08717414 chr16:71523259 ZNF19 -0.68 -5.89 -0.31 9.39e-9 Post bronchodilator FEV1; CRC cis rs9649213 0.593 rs1076272 chr7:98031005 C/G cg00277769 chr7:97922759 BAIAP2L1 -0.58 -9.9 -0.48 2.13e-20 Prostate cancer (SNP x SNP interaction); CRC cis rs9640161 0.789 rs11767409 chr7:150058043 C/T cg13722127 chr7:150037890 RARRES2 0.39 5.6 0.3 4.51e-8 Blood protein levels;Circulating chemerin levels; CRC cis rs72772090 0.634 rs17402639 chr5:96107005 A/G cg17330273 chr5:96107758 CAST;ERAP1 -0.68 -6.36 -0.33 6.85e-10 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs2072499 0.838 rs2758619 chr1:156162559 A/G cg06970220 chr1:156163860 SLC25A44 0.5 7.13 0.37 6.42e-12 Testicular germ cell tumor; CRC cis rs17270561 0.609 rs9356984 chr6:25725481 C/T cg16482183 chr6:26056742 HIST1H1C -0.74 -8.66 -0.43 2.16e-16 Iron status biomarkers; CRC cis rs514406 0.861 rs7513052 chr1:53241360 C/T cg27535305 chr1:53392650 SCP2 0.38 7.27 0.37 2.57e-12 Monocyte count; CRC cis rs3087591 0.600 rs2905808 chr17:29493993 A/T cg24425628 chr17:29625626 OMG;NF1 0.67 8.78 0.44 9.02e-17 Hip circumference; CRC cis rs6831352 0.851 rs1230164 chr4:99986023 C/G cg12011299 chr4:100065546 ADH4 0.51 9.67 0.47 1.24e-19 Alcohol dependence; CRC cis rs9427116 0.502 rs9426830 chr1:154594690 A/G cg17218026 chr1:154582156 ADAR 0.69 12.57 0.57 7.09e-30 Blood protein levels; CRC cis rs12701220 0.522 rs868833 chr7:1054973 C/G cg26769984 chr7:1090371 C7orf50 0.5 8.03 0.4 1.71e-14 Bronchopulmonary dysplasia; CRC cis rs12286929 0.637 rs34138164 chr11:115050127 A/G cg04055981 chr11:115044050 NA 0.38 5.85 0.31 1.21e-8 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs12044355 0.927 rs11585981 chr1:231833962 T/C cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX 0.44 6.21 0.32 1.6e-9 Alzheimer's disease; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg18247638 chr13:103451366 KDELC1;BIVM 0.49 6.93 0.36 2.29e-11 Response to antipsychotic treatment; CRC cis rs896854 0.654 rs13281625 chr8:95972738 T/C cg13393036 chr8:95962371 TP53INP1 -0.54 -9.26 -0.45 2.63e-18 Type 2 diabetes; CRC cis rs9916302 0.821 rs12938268 chr17:37572139 G/A cg00129232 chr17:37814104 STARD3 -0.55 -8.02 -0.4 1.92e-14 Glomerular filtration rate (creatinine); CRC cis rs2243480 1.000 rs419603 chr7:65597341 C/T cg18252515 chr7:66147081 NA -1.24 -14.68 -0.63 7.09e-38 Diabetic kidney disease; CRC trans rs2014572 0.967 rs10426174 chr19:57756055 G/A cg02674126 chr19:40336878 FBL 0.43 6.91 0.36 2.58e-11 Hyperactive-impulsive symptoms; CRC cis rs9399135 0.967 rs9389258 chr6:135361140 T/C cg24558204 chr6:135376177 HBS1L 0.5 7.94 0.4 3.2e-14 Red blood cell count; CRC cis rs17685 0.712 rs1859792 chr7:75789264 T/C cg16489192 chr7:75678113 MDH2;STYXL1 -0.38 -5.94 -0.31 7.15e-9 Coffee consumption;Coffee consumption (cups per day); CRC cis rs7095944 0.584 rs4962693 chr10:126424835 C/T cg08799069 chr10:126477246 METTL10 -0.44 -6.78 -0.35 5.46e-11 Asthma; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg01495663 chr14:21945285 RAB2B;TOX4 0.41 5.96 0.31 6.35e-9 Intelligence (multi-trait analysis); CRC cis rs870825 0.655 rs12502771 chr4:185635834 T/C cg04058563 chr4:185651563 MLF1IP 0.73 9.38 0.46 1.13e-18 Blood protein levels; CRC cis rs2243480 1.000 rs313802 chr7:65516373 A/G cg12463550 chr7:65579703 CRCP 0.75 6.82 0.35 4.5e-11 Diabetic kidney disease; CRC cis rs1552244 0.706 rs279545 chr3:9972493 A/G cg08888203 chr3:10149979 C3orf24 0.46 6.69 0.35 9.43e-11 Alzheimer's disease; CRC trans rs4386084 0.890 rs12373013 chr15:50251620 A/T cg02453146 chr1:53068587 GPX7 -0.33 -5.98 -0.31 5.92e-9 Basophil percentage of white cells;Basophil percentage of granulocytes; CRC cis rs10256972 0.552 rs6978842 chr7:1204599 A/C cg18402987 chr7:1209562 NA 0.61 9.6 0.47 2.15e-19 Longevity;Endometriosis; CRC cis rs9807989 0.507 rs1420094 chr2:103015687 C/T cg03938978 chr2:103052716 IL18RAP 0.59 10.17 0.49 2.54e-21 Asthma; CRC cis rs10267593 0.516 rs62435159 chr7:1911281 G/A cg23422044 chr7:1970798 MAD1L1 -0.46 -6.14 -0.32 2.4e-9 Coronary artery disease; CRC cis rs4713118 0.662 rs9468277 chr6:28028390 C/A cg23161317 chr6:28129485 ZNF389 0.44 5.76 0.3 1.96e-8 Parkinson's disease; CRC cis rs4689592 0.523 rs3857179 chr4:7070496 T/A cg19539972 chr4:7069911 GRPEL1 0.79 10.17 0.49 2.69e-21 Monocyte percentage of white cells; CRC cis rs9916302 0.904 rs12952384 chr17:37669536 T/C cg03013999 chr17:37608204 MED1 0.45 6.91 0.36 2.6e-11 Glomerular filtration rate (creatinine); CRC trans rs2302612 0.514 rs7572853 chr2:102853783 G/A cg25110734 chr5:149535650 PDGFRB -0.48 -6.58 -0.34 1.9e-10 Serum protein levels (sST2); CRC cis rs10504229 0.683 rs72649188 chr8:58108829 A/G cg04204079 chr8:58130323 NA -0.46 -5.8 -0.3 1.58e-8 Developmental language disorder (linguistic errors); CRC cis rs13064411 0.627 rs28710051 chr3:113143531 G/A cg18753928 chr3:113234510 CCDC52 -0.64 -8.92 -0.44 3.24e-17 Response to simvastatin treatment (PCSK9 protein level change); CRC trans rs7615952 0.800 rs12489350 chr3:125644116 T/C cg16558177 chr4:4109446 NA -0.48 -6.29 -0.33 1.03e-9 Blood pressure (smoking interaction); CRC cis rs7635838 0.684 rs2594968 chr3:11352442 T/C cg00170343 chr3:11313890 ATG7 0.48 7.46 0.38 7.66e-13 HDL cholesterol; CRC cis rs10504229 0.679 rs16920056 chr8:58106218 C/A cg24829409 chr8:58192753 C8orf71 -0.56 -8.01 -0.4 2.05e-14 Developmental language disorder (linguistic errors); CRC cis rs12826942 0.571 rs17224156 chr12:42446725 C/T cg11827402 chr12:42719852 PPHLN1;ZCRB1 0.58 6.15 0.32 2.21e-9 Coronary artery disease; CRC cis rs875971 0.651 rs313829 chr7:65552497 A/G cg11764359 chr7:65958608 NA -0.49 -6.65 -0.34 1.21e-10 Aortic root size; CRC cis rs7827545 1.000 rs62523736 chr8:135560916 A/T cg17885191 chr8:135476712 NA 0.57 7.64 0.39 2.45e-13 Hypertension (SNP x SNP interaction); CRC cis rs77972916 0.505 rs6756575 chr2:43528519 C/G cg06169590 chr2:43455088 ZFP36L2;LOC100129726 -0.66 -7.83 -0.4 6.97e-14 Granulocyte percentage of myeloid white cells; CRC trans rs7937682 0.889 rs1940529 chr11:111498523 G/C cg18187862 chr3:45730750 SACM1L 0.44 6.34 0.33 7.43e-10 Primary sclerosing cholangitis; CRC cis rs4731207 0.596 rs922711 chr7:124604304 A/G cg23710748 chr7:124431027 NA -0.38 -6.08 -0.32 3.35e-9 Cutaneous malignant melanoma; CRC cis rs9747201 0.963 rs11077982 chr17:80147377 G/C cg09264619 chr17:80180166 NA -0.5 -7.28 -0.37 2.49e-12 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs155076 1.000 rs261406 chr13:21855854 G/A cg25811766 chr13:21894605 NA -0.59 -6.16 -0.32 2.17e-9 White matter hyperintensity burden; CRC cis rs7618915 0.501 rs3852066 chr3:52621839 C/T cg11645453 chr3:52864694 ITIH4 0.36 6.48 0.34 3.43e-10 Bipolar disorder; CRC cis rs910316 0.737 rs175077 chr14:75506875 G/A cg11812906 chr14:75593930 NEK9 -0.6 -9.27 -0.46 2.46e-18 Height; CRC cis rs9296095 1.000 rs5745568 chr6:33548394 G/T cg14003231 chr6:33640908 ITPR3 0.54 7.73 0.39 1.28e-13 Platelet count; CRC cis rs6951245 0.572 rs79396675 chr7:1055047 C/T cg21664854 chr7:1097933 C7orf50;GPR146 0.74 5.72 0.3 2.34e-8 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs1153858 0.945 rs1974981 chr15:45729123 C/T cg14582100 chr15:45693742 SPATA5L1 -0.29 -6.08 -0.32 3.33e-9 Homoarginine levels; CRC cis rs9649213 0.593 rs3823740 chr7:97957104 T/G cg08684580 chr7:98029266 BAIAP2L1 -0.32 -5.65 -0.3 3.44e-8 Prostate cancer (SNP x SNP interaction); CRC trans rs8073060 0.592 rs225306 chr17:33920036 A/C cg19694781 chr19:47549865 TMEM160 0.59 8.96 0.44 2.41e-17 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg11786582 chr17:57233134 PRR11;SKA2 0.37 5.98 0.31 5.84e-9 Liver disease severity in Alagille syndrome; CRC cis rs6089584 0.816 rs4925336 chr20:60627180 A/G cg18761221 chr20:60518478 NA 0.48 7.78 0.39 9.42e-14 Body mass index; CRC cis rs6598955 0.670 rs12733645 chr1:26540356 G/T cg00852783 chr1:26633632 UBXN11 0.45 7.31 0.37 2.04e-12 Obesity-related traits; CRC trans rs1346081 0.786 rs1425645 chr4:68028175 C/T cg10799186 chr3:139396487 NMNAT3 0.49 6.02 0.31 4.56e-9 Intelligence (multi-trait analysis); CRC cis rs853679 0.723 rs1736904 chr6:28219270 G/A cg02683197 chr6:28174875 NA 0.6 6.8 0.35 4.81e-11 Depression; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg13370280 chr6:137539688 IFNGR1 0.45 6.54 0.34 2.31e-10 Response to antipsychotic treatment; CRC cis rs7772486 0.754 rs702319 chr6:146006117 T/C cg13319975 chr6:146136371 FBXO30 0.46 6.57 0.34 1.92e-10 Lobe attachment (rater-scored or self-reported); CRC cis rs9398803 0.865 rs2130603 chr6:126826819 A/C cg19875578 chr6:126661172 C6orf173 0.42 5.92 0.31 8.1e-9 Male-pattern baldness; CRC cis rs4713118 0.911 rs9461406 chr6:27719764 C/T cg06470822 chr6:28175283 NA -0.73 -9.03 -0.45 1.49e-17 Parkinson's disease; CRC cis rs10927875 0.541 rs761759 chr1:16342350 A/T cg22431228 chr1:16359049 CLCNKA -0.37 -6.72 -0.35 8.23e-11 Dilated cardiomyopathy; CRC trans rs875971 0.660 rs2191268 chr7:66110224 C/T cg16908901 chr1:94054835 BCAR3 0.36 5.99 0.31 5.53e-9 Aortic root size; CRC cis rs7937682 1.000 rs505372 chr11:111507189 A/C cg19812747 chr11:111475976 SIK2 -0.58 -9.73 -0.47 8.16e-20 Primary sclerosing cholangitis; CRC cis rs6484504 0.532 rs2150212 chr11:31255935 G/A cg14844989 chr11:31128820 NA -0.34 -5.9 -0.31 9.06e-9 Red blood cell count; CRC cis rs12188164 0.543 rs2672757 chr5:454732 A/G cg21625146 chr5:486483 SLC9A3 0.37 5.79 0.3 1.67e-8 Cystic fibrosis severity; CRC cis rs597539 0.690 rs552517 chr11:68625286 T/G cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.85 14.08 0.61 1.51e-35 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs9430161 0.579 rs9659356 chr1:11034817 A/G cg27631724 chr1:11040367 C1orf127 0.29 5.89 0.31 9.67e-9 Ewing sarcoma; CRC cis rs644799 0.544 rs1150360 chr11:95512060 A/G cg25622487 chr11:95524042 FAM76B;CEP57 0.58 8.65 0.43 2.39e-16 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs9549260 0.620 rs12583418 chr13:41195411 G/A cg21288729 chr13:41239152 FOXO1 0.43 6.71 0.35 8.45e-11 Red blood cell count; CRC cis rs11098499 0.691 rs10010355 chr4:120261043 A/G cg24375607 chr4:120327624 NA 0.47 7.72 0.39 1.42e-13 Corneal astigmatism; CRC cis rs11122272 0.735 rs2749716 chr1:231486908 T/C cg06096015 chr1:231504339 EGLN1 0.42 6.4 0.33 5.47e-10 Hemoglobin concentration; CRC cis rs597539 0.654 rs7107137 chr11:68623712 A/G cg04772025 chr11:68637568 NA 0.54 8.07 0.41 1.34e-14 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs7615952 0.576 rs6780025 chr3:125815624 A/C cg02772935 chr3:125709198 NA -0.5 -5.83 -0.31 1.3e-8 Blood pressure (smoking interaction); CRC cis rs1129187 0.755 rs2274517 chr6:42932715 A/G cg27588902 chr6:42928151 GNMT 0.4 7.28 0.37 2.55e-12 Alzheimer's disease in APOE e4+ carriers; CRC cis rs13108904 0.870 rs11727987 chr4:1261435 A/G cg00684032 chr4:1343700 KIAA1530 0.46 6.76 0.35 6.27e-11 Obesity-related traits; CRC cis rs950169 0.922 rs12910334 chr15:84958318 G/A cg11189052 chr15:85197271 WDR73 0.63 8.71 0.43 1.51e-16 Schizophrenia; CRC cis rs9467773 0.967 rs6932865 chr6:26540166 C/A cg09904177 chr6:26538194 HMGN4 0.86 14.87 0.63 1.27e-38 Intelligence (multi-trait analysis); CRC trans rs12908161 0.853 rs12912342 chr15:85248216 T/C cg00352043 chr22:38863594 KDELR3 0.33 6.05 0.32 3.98e-9 Schizophrenia; CRC cis rs7727544 0.904 rs7736102 chr5:131604257 G/A cg02033258 chr5:131593261 PDLIM4 0.35 6.76 0.35 6.29e-11 Blood metabolite levels; CRC cis rs6540556 0.769 rs2272867 chr1:209929579 C/A cg05527609 chr1:210001259 C1orf107 -0.61 -6.8 -0.35 5e-11 Red blood cell count; CRC cis rs1707322 1.000 rs11211205 chr1:46321874 C/T cg06784218 chr1:46089804 CCDC17 0.51 8.99 0.44 1.94e-17 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs3820068 0.581 rs72645874 chr1:15926238 C/G cg24675056 chr1:15929824 NA 0.49 6.66 0.34 1.12e-10 Systolic blood pressure; CRC cis rs1865760 0.929 rs9358896 chr6:25943197 C/A cg17691542 chr6:26056736 HIST1H1C 0.53 7.67 0.39 1.95e-13 Height; CRC cis rs4319547 0.695 rs7969429 chr12:122875606 A/G cg23029597 chr12:123009494 RSRC2 -0.55 -6.7 -0.35 9.14e-11 Body mass index; CRC cis rs116095464 0.558 rs13354585 chr5:242263 G/C cg22857025 chr5:266934 NA -1.25 -16.79 -0.68 4.1e-46 Breast cancer; CRC cis rs11247915 1.000 rs11247915 chr1:26650550 G/T cg08133631 chr1:26527909 CATSPER4 -0.35 -5.76 -0.3 1.91e-8 Obesity-related traits; CRC cis rs9534288 0.830 rs1548325 chr13:46635101 A/G cg15192986 chr13:46630673 CPB2 -0.75 -10.92 -0.52 6.95e-24 Blood protein levels; CRC cis rs1005277 0.522 rs200943 chr10:38148730 A/G cg25517755 chr10:38738941 LOC399744 -0.45 -6.6 -0.34 1.61e-10 Extrinsic epigenetic age acceleration; CRC cis rs7705042 0.828 rs249638 chr5:141530696 G/C cg08523384 chr5:141488047 NDFIP1 -0.32 -5.71 -0.3 2.48e-8 Asthma; CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg09564133 chr5:176738847 MXD3 -0.54 -6.63 -0.34 1.4e-10 Diisocyanate-induced asthma; CRC cis rs2153535 0.541 rs9405386 chr6:8458067 C/G cg21535247 chr6:8435926 SLC35B3 0.51 7.9 0.4 4.36e-14 Motion sickness; CRC cis rs763121 0.853 rs5757232 chr22:39071677 C/T cg06022373 chr22:39101656 GTPBP1 0.8 12.62 0.57 4.84e-30 Menopause (age at onset); CRC cis rs7259376 0.936 rs2099354 chr19:22539532 C/A cg02657401 chr19:22469223 NA -0.34 -7.62 -0.39 2.73e-13 Menopause (age at onset); CRC cis rs2274471 0.699 rs10815160 chr9:5116616 A/C cg03390472 chr9:5043263 JAK2 -0.5 -5.93 -0.31 7.49e-9 Crohn's disease; CRC cis rs6714710 0.603 rs6757357 chr2:98491750 T/C cg26665480 chr2:98280029 ACTR1B 0.52 7.23 0.37 3.38e-12 Posterior cortical atrophy and Alzheimer's disease; CRC cis rs9457247 0.565 rs2038580 chr6:167456490 A/T cg07741184 chr6:167504864 NA 0.44 7.39 0.38 1.2e-12 Crohn's disease; CRC cis rs9487051 0.768 rs1766814 chr6:109526696 G/A cg21918786 chr6:109611834 NA -0.34 -5.84 -0.31 1.28e-8 Reticulocyte fraction of red cells; CRC cis rs926938 0.560 rs360610 chr1:115393915 T/C cg12756093 chr1:115239321 AMPD1 0.58 8.6 0.43 3.29e-16 Autism; CRC cis rs172166 0.694 rs203877 chr6:28048624 T/C cg12273811 chr6:28175739 NA 0.59 8.64 0.43 2.56e-16 Cardiac Troponin-T levels; CRC cis rs477692 0.549 rs7079744 chr10:131454790 G/A cg05714579 chr10:131428358 MGMT -0.48 -6.48 -0.34 3.42e-10 Response to temozolomide; CRC trans rs1814175 0.587 rs847628 chr11:49927064 A/T cg03929089 chr4:120376271 NA -0.91 -16.07 -0.66 2.65e-43 Height; CRC cis rs7635838 0.859 rs9826803 chr3:11461863 G/A cg00170343 chr3:11313890 ATG7 0.38 5.69 0.3 2.87e-8 HDL cholesterol; CRC cis rs6582630 0.555 rs11181053 chr12:38271364 T/C cg26384229 chr12:38710491 ALG10B -0.44 -6.35 -0.33 7.15e-10 Drug-induced liver injury (flucloxacillin); CRC cis rs3749237 1.000 rs3749237 chr3:49770032 C/T cg05072774 chr3:49840536 C3orf54 -0.43 -5.64 -0.3 3.59e-8 Resting heart rate; CRC cis rs7618915 0.547 rs2164884 chr3:52629633 C/T cg08222913 chr3:52553049 STAB1 -0.34 -6.21 -0.32 1.64e-9 Bipolar disorder; CRC cis rs600626 0.529 rs2008476 chr11:75470813 C/T cg24262691 chr11:75473276 NA 0.53 7.9 0.4 4.18e-14 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CRC trans rs79976124 0.760 rs74295030 chr6:66654441 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.75 9.52 0.46 3.87e-19 Type 2 diabetes; CRC cis rs6963495 0.745 rs68153235 chr7:105184832 A/C cg19920283 chr7:105172520 RINT1 0.54 6.75 0.35 6.64e-11 Bipolar disorder (body mass index interaction); CRC cis rs9325144 0.624 rs7979541 chr12:39129679 T/C cg26384229 chr12:38710491 ALG10B -0.45 -6.47 -0.34 3.5e-10 Morning vs. evening chronotype; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg25222319 chr17:3500274 TRPV1 -0.33 -6.02 -0.31 4.61e-9 Liver disease severity in Alagille syndrome; CRC cis rs354033 1.000 rs354034 chr7:149290497 G/A cg24335155 chr7:149193227 ZNF746 0.38 6.19 0.32 1.8e-9 Multiple sclerosis; CRC cis rs12472274 0.646 rs11688732 chr2:239096622 G/T cg17459225 chr2:239074497 NA 0.7 8.18 0.41 6.05e-15 Phospholipid levels (plasma); CRC cis rs35146811 0.735 rs7811662 chr7:99792608 A/G cg13334819 chr7:99746414 C7orf59 -0.52 -6.83 -0.35 4.05e-11 Coronary artery disease; CRC cis rs35110281 0.776 rs9306159 chr21:45061839 G/T cg01579765 chr21:45077557 HSF2BP -0.39 -7.53 -0.38 4.91e-13 Mean corpuscular volume; CRC cis rs427941 0.703 rs201442 chr7:101737627 C/T cg06246474 chr7:101738831 CUX1 -0.45 -7.02 -0.36 1.25e-11 Plasma omega-3 polyunsaturated fatty acid level (eicosapentaenoic acid); CRC cis rs2032447 0.898 rs807205 chr6:26075035 C/G cg03264133 chr6:25882463 NA -0.47 -6.41 -0.33 5.06e-10 Intelligence (multi-trait analysis); CRC cis rs7089973 0.872 rs7072364 chr10:116620840 G/A cg23260525 chr10:116636907 FAM160B1 0.31 6.82 0.35 4.38e-11 Bipolar disorder or attention deficit hyperactivity disorder; CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg00167275 chr10:88854588 FAM35A;GLUD1 0.39 6.43 0.33 4.54e-10 Obesity-related traits; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg01973771 chr19:2740143 SLC39A3 0.41 6.0 0.31 5.21e-9 Intelligence (multi-trait analysis); CRC cis rs1799949 1.000 rs4793231 chr17:41427469 A/G cg19454999 chr17:41278357 BRCA1;NBR2 0.52 8.0 0.4 2.15e-14 Menopause (age at onset); CRC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg24013378 chr11:69480958 ORAOV1 0.42 6.73 0.35 7.46e-11 Asthma; CRC cis rs9903692 0.908 rs11079809 chr17:46198221 T/C cg21215337 chr17:46176117 CBX1 -0.43 -7.95 -0.4 3.09e-14 Pulse pressure; CRC cis rs3858526 0.727 rs10769353 chr11:5954809 C/T cg05234568 chr11:5960015 NA 0.7 11.21 0.53 6.36e-25 DNA methylation (variation); CRC cis rs6681460 0.634 rs4142763 chr1:66998036 A/G cg02459107 chr1:67143332 SGIP1 0.37 5.7 0.3 2.6e-8 Presence of antiphospholipid antibodies; CRC cis rs6681460 0.604 rs7546825 chr1:67101802 A/G cg02459107 chr1:67143332 SGIP1 0.32 5.72 0.3 2.39e-8 Presence of antiphospholipid antibodies; CRC cis rs17345786 0.861 rs11711808 chr3:101235101 T/C cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.59 6.95 0.36 2.01e-11 Colonoscopy-negative controls vs population controls; CRC cis rs873946 0.648 rs3750578 chr10:134563366 A/G cg18305652 chr10:134549665 INPP5A 0.5 6.46 0.34 3.66e-10 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CRC cis rs1552244 1.000 rs7628448 chr3:10146828 G/A cg13047869 chr3:10149882 C3orf24 0.58 7.65 0.39 2.23e-13 Alzheimer's disease; CRC cis rs7107174 1.000 rs10899477 chr11:78052104 A/T cg02023728 chr11:77925099 USP35 0.5 7.56 0.38 4.15e-13 Testicular germ cell tumor; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg11227075 chr10:52750930 PRKG1 0.39 6.04 0.32 4.18e-9 Response to antipsychotic treatment; CRC cis rs11190604 1.000 rs11190556 chr10:102209223 G/A cg16342193 chr10:102329863 NA -0.35 -5.83 -0.31 1.29e-8 Palmitoleic acid (16:1n-7) levels; CRC trans rs2303319 0.504 rs62189046 chr2:162612371 C/G cg22902534 chr3:183892754 AP2M1 -0.7 -6.1 -0.32 2.96e-9 Cognitive function; CRC cis rs7666738 0.791 rs4440223 chr4:99044796 G/A cg05340658 chr4:99064831 C4orf37 0.6 9.35 0.46 1.36e-18 Colonoscopy-negative controls vs population controls; CRC cis rs1983170 0.778 rs906241 chr1:92012154 G/T cg21854759 chr1:92012499 NA -0.49 -6.69 -0.35 9.54e-11 Eosinophil percentage of white cells; CRC cis rs9905704 0.918 rs302857 chr17:56692387 C/G cg12560992 chr17:57184187 TRIM37 0.56 7.65 0.39 2.25e-13 Testicular germ cell tumor; CRC trans rs2727020 0.521 rs10839296 chr11:49537617 T/C cg15704280 chr7:45808275 SEPT13 0.76 10.02 0.48 8.6e-21 Coronary artery disease; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg09278885 chr1:2126389 C1orf86;LOC100128003 0.49 6.74 0.35 7.06e-11 Response to antipsychotic treatment; CRC cis rs7224610 0.898 rs4299205 chr17:53366146 T/G cg02383154 chr17:53343283 HLF -0.34 -5.76 -0.3 1.93e-8 Urate levels; CRC cis rs12692738 0.526 rs446315 chr2:165609194 T/C cg03182029 chr2:165697222 COBLL1 0.48 5.6 0.3 4.46e-8 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);Waist-to-hip ratio adjusted for BMI in non-smokers;Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction);Waist-to-hip ratio adjusted for body mass index; CRC cis rs79839061 0.610 rs2279181 chr4:882643 A/G cg07828340 chr4:882639 GAK -1.1 -11.67 -0.54 1.45e-26 Intelligence (multi-trait analysis); CRC cis rs3796352 1.000 rs11720191 chr3:53013839 T/C cg27565382 chr3:53032988 SFMBT1 0.65 5.68 0.3 2.94e-8 Immune reponse to smallpox (secreted IL-2); CRC cis rs597539 0.652 rs569777 chr11:68706848 G/A cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.86 14.64 0.63 9.82e-38 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs7107174 1.000 rs948662 chr11:77979829 A/G cg02023728 chr11:77925099 USP35 0.53 8.17 0.41 6.81e-15 Testicular germ cell tumor; CRC cis rs7259376 0.905 rs2082480 chr19:22538650 G/A cg02657401 chr19:22469223 NA -0.34 -7.62 -0.39 2.73e-13 Menopause (age at onset); CRC cis rs6500602 0.647 rs4786501 chr16:4536165 G/T cg08645402 chr16:4508243 NA -0.65 -11.48 -0.53 6.9e-26 Schizophrenia; CRC cis rs10504229 0.683 rs11785258 chr8:58132893 A/G cg02290350 chr8:58132656 NA -0.58 -8.16 -0.41 7.29e-15 Developmental language disorder (linguistic errors); CRC cis rs9322193 0.923 rs11155677 chr6:150078089 C/G cg13206674 chr6:150067644 NUP43 0.68 10.28 0.49 1.08e-21 Lung cancer; CRC cis rs13382862 0.895 rs13385499 chr2:20882413 A/G cg09074113 chr2:20870087 GDF7 -0.38 -7.22 -0.37 3.61e-12 Abdominal aortic aneurysm; CRC cis rs853679 0.517 rs1853097 chr6:28058635 A/G cg02631126 chr6:28058918 ZSCAN12L1 0.3 6.09 0.32 3.18e-9 Depression; CRC cis rs2842992 0.915 rs1967802 chr6:160097791 G/A cg16489826 chr6:160211363 TCP1;MRPL18 0.47 5.66 0.3 3.29e-8 Age-related macular degeneration (geographic atrophy); CRC cis rs11229555 1.000 rs10896795 chr11:58366561 A/G cg15696309 chr11:58395628 NA -0.95 -13.38 -0.59 6.93e-33 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; CRC cis rs910316 1.000 rs10143132 chr14:75525850 G/A cg11812906 chr14:75593930 NEK9 0.63 9.96 0.48 1.38e-20 Height; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg19871494 chr1:1310280 AURKAIP1 0.39 6.31 0.33 8.77e-10 Liver disease severity in Alagille syndrome; CRC cis rs2976388 1.000 rs2978982 chr8:143763490 T/C cg04969067 chr8:143858791 LYNX1 -0.35 -5.98 -0.31 5.67e-9 Urinary tract infection frequency; CRC cis rs2836974 0.931 rs2836968 chr21:40642386 A/G cg06238570 chr21:40685208 BRWD1 0.79 10.86 0.51 1.11e-23 Cognitive function; CRC cis rs8016982 0.674 rs1951615 chr14:81671762 G/A cg01989461 chr14:81687754 GTF2A1 0.63 10.3 0.49 9.81e-22 Schizophrenia; CRC cis rs1552244 0.572 rs41464050 chr3:10158393 A/G cg08888203 chr3:10149979 C3orf24 0.7 8.5 0.42 6.51e-16 Alzheimer's disease; CRC trans rs11885103 0.543 rs1320362 chr2:564079 G/T cg12228919 chr15:44955936 SPG11 -0.45 -6.66 -0.34 1.13e-10 Heschl's gyrus morphology; CRC cis rs6461049 0.638 rs1859993 chr7:2183702 A/G cg04267008 chr7:1944627 MAD1L1 -0.44 -6.19 -0.32 1.77e-9 Schizophrenia; CRC cis rs8180040 0.739 rs4683320 chr3:47152992 C/T cg02527881 chr3:46936655 PTH1R -0.38 -6.97 -0.36 1.78e-11 Colorectal cancer; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg25002044 chr14:68141349 VTI1B 0.4 6.15 0.32 2.24e-9 Intelligence (multi-trait analysis); CRC cis rs936229 0.626 rs3765066 chr15:75140854 G/A cg14664628 chr15:75095509 CSK -0.69 -11.46 -0.53 8.09e-26 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); CRC cis rs4132509 0.744 rs6687181 chr1:243878518 C/T cg21452805 chr1:244014465 NA 0.58 7.52 0.38 5.14e-13 RR interval (heart rate); CRC cis rs13315871 0.929 rs13080398 chr3:58300282 A/G cg20936604 chr3:58311152 NA -0.72 -6.86 -0.35 3.51e-11 Cholesterol, total; CRC cis rs2976388 0.566 rs13250661 chr8:143804134 C/T cg22687807 chr8:143858763 LYNX1 -0.47 -7.77 -0.39 9.95e-14 Urinary tract infection frequency; CRC cis rs9818758 0.556 rs9814987 chr3:49207849 T/C cg00383909 chr3:49044727 WDR6 1.07 10.94 0.52 5.69e-24 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; CRC trans rs7944735 0.767 rs1017875 chr11:47999218 C/T cg15704280 chr7:45808275 SEPT13 0.56 6.32 0.33 8.44e-10 Intraocular pressure; CRC cis rs9649213 0.593 rs6975156 chr7:97925534 T/C cg21770322 chr7:97807741 LMTK2 0.51 8.28 0.42 3.2e-15 Prostate cancer (SNP x SNP interaction); CRC cis rs7208859 0.673 rs55658077 chr17:29156519 A/G cg01831904 chr17:28903510 LRRC37B2 -0.61 -6.43 -0.33 4.58e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs56399783 0.901 rs73049305 chr7:2778755 C/T cg19731401 chr7:2775893 GNA12 0.67 7.26 0.37 2.84e-12 Childhood ear infection; CRC cis rs2019137 0.868 rs3748916 chr2:113984033 C/T cg07594247 chr2:113993304 PAX8;LOC440839;LOC654433 -0.4 -5.92 -0.31 8.29e-9 Lymphocyte counts; CRC cis rs10946940 0.896 rs12208078 chr6:27498581 G/A cg15845792 chr6:28175446 NA -0.45 -6.16 -0.32 2.14e-9 Systemic lupus erythematosus; CRC cis rs6088580 0.634 rs6058073 chr20:33116483 T/C cg08999081 chr20:33150536 PIGU 0.63 11.77 0.54 6.19e-27 Glomerular filtration rate (creatinine); CRC cis rs2455799 0.574 rs2455801 chr3:15701857 C/T cg16303742 chr3:15540471 COLQ -0.35 -5.61 -0.3 4.28e-8 Mean platelet volume; CRC cis rs7945705 0.791 rs7944560 chr11:8817276 A/T cg12365402 chr11:9010492 NRIP3 0.36 5.97 0.31 6.18e-9 Hemoglobin concentration; CRC cis rs4332037 0.851 rs73050128 chr7:1961882 C/A cg02421172 chr7:1938701 MAD1L1 0.45 6.05 0.32 3.98e-9 Bipolar disorder; CRC trans rs17641971 1.000 rs73579360 chr8:49920586 C/T cg25069010 chr20:34828328 C20orf4 -0.42 -6.09 -0.32 3.23e-9 Blood metabolite levels; CRC cis rs12477438 0.501 rs11685756 chr2:99766215 T/C cg14399236 chr2:99771627 LIPT1;TSGA10 0.79 13.62 0.6 8.2e-34 Chronic sinus infection; CRC cis rs9368481 0.761 rs9357028 chr6:26967224 T/G cg05192639 chr6:26864778 GUSBL1 -0.35 -6.11 -0.32 2.79e-9 Autism spectrum disorder or schizophrenia; CRC cis rs7591163 1.000 rs4300818 chr2:228713255 G/T cg21577049 chr2:228736449 WDR69 -0.47 -6.22 -0.32 1.5e-9 Blood pressure; CRC cis rs8060686 0.641 rs8058690 chr16:68136622 T/G cg26727032 chr16:67993705 SLC12A4 -0.6 -8.11 -0.41 1.04e-14 HDL cholesterol;Metabolic syndrome; CRC cis rs1448094 0.533 rs4412812 chr12:86151238 G/A cg25456477 chr12:86230367 RASSF9 -0.36 -6.16 -0.32 2.13e-9 Major depressive disorder; CRC cis rs4713118 0.539 rs200988 chr6:27819353 A/C cg02683197 chr6:28174875 NA 0.68 9.43 0.46 7.91e-19 Parkinson's disease; CRC cis rs11212617 0.934 rs172896 chr11:108217049 T/G cg01991180 chr11:108092276 ATM;NPAT 0.42 6.22 0.32 1.51e-9 Response to metformin in type 2 diabetes (glycemic); CRC cis rs3862030 0.503 rs6584505 chr10:104254412 C/A cg04362960 chr10:104952993 NT5C2 -0.41 -5.72 -0.3 2.37e-8 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for body mass index; CRC cis rs9322193 0.884 rs9383864 chr6:150173105 T/C cg13206674 chr6:150067644 NUP43 0.58 8.17 0.41 6.81e-15 Lung cancer; CRC cis rs8014204 0.533 rs12889955 chr14:75172999 G/A cg03030879 chr14:75389066 RPS6KL1 -0.4 -6.35 -0.33 7.08e-10 Caffeine consumption; CRC cis rs6088590 0.931 rs12625149 chr20:33425812 A/C cg08999081 chr20:33150536 PIGU -0.44 -7.23 -0.37 3.36e-12 Coronary artery disease; CRC cis rs769267 0.930 rs4808957 chr19:19567248 A/G cg02546618 chr19:19431379 KIAA0892;SF4 0.46 6.38 0.33 6.09e-10 Tonsillectomy; CRC trans rs1814175 0.533 rs4528310 chr11:49983106 C/A cg11707556 chr5:10655725 ANKRD33B -0.52 -10.05 -0.48 6.61e-21 Height; CRC cis rs7216064 0.953 rs75231441 chr17:65885485 A/G cg12091567 chr17:66097778 LOC651250 -0.67 -7.74 -0.39 1.24e-13 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CRC cis rs861020 0.630 rs616544 chr1:210007368 T/C cg09163369 chr1:210001066 C1orf107 0.41 5.76 0.3 1.91e-8 Orofacial clefts; CRC cis rs4925325 0.955 rs1776262 chr20:60516023 G/T cg12751644 chr20:60527061 NA 0.49 7.81 0.4 7.96e-14 Obesity-related traits; CRC cis rs1799949 0.501 rs2343819 chr17:41409653 T/G cg05368731 chr17:41323189 NBR1 0.67 10.08 0.49 5.26e-21 Menopause (age at onset); CRC trans rs16846053 0.579 rs57887363 chr2:162588720 C/T cg25193742 chr10:104614220 C10orf32 -0.79 -6.47 -0.34 3.54e-10 Blood osmolality (transformed sodium); CRC cis rs4903604 0.581 rs4899658 chr14:78035392 A/T cg18872420 chr14:78023429 SPTLC2 -0.34 -5.8 -0.3 1.58e-8 Gut microbiome composition (winter); CRC cis rs12745968 0.589 rs10874725 chr1:93090850 G/A cg17283838 chr1:93427260 FAM69A -0.46 -6.32 -0.33 8.45e-10 Bipolar disorder and schizophrenia; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg21227347 chr9:117374170 C9orf91 0.49 7.11 0.36 7.04e-12 Response to antipsychotic treatment; CRC cis rs7909074 1.000 rs4481983 chr10:45400428 G/T cg05187965 chr10:45406764 TMEM72 -0.36 -8.27 -0.42 3.24e-15 Mean corpuscular volume; CRC cis rs853679 0.517 rs9393886 chr6:28050039 T/G cg18032046 chr6:28092343 ZSCAN16 -0.51 -6.05 -0.32 3.87e-9 Depression; CRC cis rs7959452 0.640 rs1598543 chr12:69688757 G/T cg22834771 chr12:69754056 YEATS4 -0.42 -5.98 -0.31 5.69e-9 Blood protein levels; CRC cis rs7264396 0.635 rs6060675 chr20:34493614 C/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.58 -9.92 -0.48 1.82e-20 Total cholesterol levels; CRC cis rs7666738 0.830 rs28515641 chr4:98726419 G/A cg05340658 chr4:99064831 C4orf37 0.54 8.0 0.4 2.21e-14 Colonoscopy-negative controls vs population controls; CRC cis rs1018836 0.892 rs2187981 chr8:91549629 T/C cg16814680 chr8:91681699 NA -0.64 -10.22 -0.49 1.74e-21 Ejection fraction in Tripanosoma cruzi seropositivity; CRC cis rs2742417 0.603 rs2742372 chr3:45783472 T/C cg04837898 chr3:45731254 SACM1L -0.47 -7.57 -0.39 3.81e-13 Response to anti-depressant treatment in major depressive disorder; CRC cis rs2294693 0.945 rs2073015 chr6:41008747 A/G cg14769373 chr6:40998127 UNC5CL -0.47 -6.03 -0.32 4.3e-9 Gastric cancer;Non-cardia gastric cancer; CRC cis rs644799 0.965 rs11021317 chr11:95517576 C/T cg25478527 chr11:95522999 CEP57;FAM76B 0.53 7.88 0.4 4.93e-14 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs6696846 0.691 rs11240370 chr1:205118336 T/G cg00857998 chr1:205179979 DSTYK 0.46 6.27 0.33 1.14e-9 Red blood cell count; CRC cis rs7901135 0.924 rs2393501 chr10:60563326 C/A cg23799393 chr10:60588674 BICC1 0.37 5.63 0.3 3.87e-8 Morning vs. evening chronotype; CRC cis rs6912958 0.712 rs4498321 chr6:88339251 G/C cg08069147 chr6:88032118 GJB7;C6orf162 -0.57 -8.61 -0.43 3.14e-16 Monocyte percentage of white cells; CRC cis rs78545713 0.649 rs114015443 chr6:26221979 A/G cg01420254 chr6:26195488 NA 0.73 6.04 0.32 4.13e-9 Iron status biomarkers (total iron binding capacity); CRC cis rs9894429 0.738 rs8077038 chr17:79577127 T/G cg18240062 chr17:79603768 NPLOC4 -0.67 -11.91 -0.55 2.01e-27 Eye color traits; CRC cis rs2120019 1.000 rs8033837 chr15:75353975 A/C cg17294928 chr15:75287854 SCAMP5 -0.77 -11.25 -0.53 4.55e-25 Blood trace element (Zn levels); CRC cis rs11997175 0.574 rs58858314 chr8:33658221 T/C cg04338863 chr8:33670619 NA 0.37 6.44 0.33 4.22e-10 Body mass index; CRC cis rs7044106 0.791 rs4836830 chr9:123483668 A/G cg14255062 chr9:123606675 PSMD5;LOC253039 0.48 7.14 0.37 6.06e-12 Hip circumference adjusted for BMI; CRC cis rs6951245 1.000 rs1997243 chr7:1083777 A/G cg20603222 chr7:1096387 C7orf50;GPR146 -0.68 -7.91 -0.4 4e-14 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs11608355 1.000 rs10774692 chr12:109862324 G/T cg19025524 chr12:109796872 NA -0.46 -6.52 -0.34 2.61e-10 Neuroticism; CRC cis rs6952808 1.000 rs6977733 chr7:1886725 A/T cg04267008 chr7:1944627 MAD1L1 0.76 10.83 0.51 1.42e-23 Bipolar disorder and schizophrenia; CRC cis rs7781266 0.842 rs73150821 chr7:133244026 C/T cg03336402 chr7:133662267 EXOC4 0.49 5.78 0.3 1.74e-8 Educational attainment (college completion); CRC cis rs12291225 0.585 rs11023197 chr11:14380998 G/A cg05501817 chr11:14380813 RRAS2 -0.47 -6.57 -0.34 1.92e-10 Sense of smell; CRC cis rs4076764 0.958 rs11580702 chr1:163385523 C/G cg24596788 chr1:163392923 NA -0.65 -10.29 -0.49 1.06e-21 Motion sickness; CRC cis rs7626444 0.565 rs7613010 chr3:196490221 G/T cg12930392 chr3:196481615 PAK2 0.39 6.92 0.36 2.43e-11 Monocyte count; CRC trans rs13046373 0.905 rs4816372 chr21:32077414 A/T cg00010168 chr10:99258642 MMS19;UBTD1 -0.41 -6.16 -0.32 2.18e-9 HDL cholesterol; CRC trans rs916888 0.773 rs199443 chr17:44819565 C/T cg01341218 chr17:43662625 NA 0.94 10.32 0.49 7.94e-22 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC trans rs12310956 0.515 rs1830086 chr12:33958874 C/T cg26384229 chr12:38710491 ALG10B 0.52 6.57 0.34 1.99e-10 Morning vs. evening chronotype; CRC cis rs62045849 0.557 rs3743982 chr16:89181139 T/G cg08015503 chr16:89190385 ACSF3 -0.95 -7.53 -0.38 4.9e-13 Red blood cell count; CRC cis rs6499255 0.951 rs7196943 chr16:69592449 T/A cg04110750 chr16:69646130 NFAT5 -0.56 -7.67 -0.39 1.9e-13 IgE levels; CRC cis rs13118159 0.801 rs1128427 chr4:1330759 T/C cg15763984 chr4:1342303 KIAA1530 0.48 8.33 0.42 2.25e-15 Longevity; CRC cis rs9487051 0.738 rs449850 chr6:109525045 A/G cg01475377 chr6:109611718 NA -0.34 -5.93 -0.31 7.68e-9 Reticulocyte fraction of red cells; CRC cis rs7666738 0.830 rs13102652 chr4:99006737 T/G cg17366294 chr4:99064904 C4orf37 0.44 7.39 0.38 1.19e-12 Colonoscopy-negative controls vs population controls; CRC cis rs1799949 1.000 rs1824889 chr17:41421876 C/G cg23758822 chr17:41437982 NA 0.79 13.41 0.59 4.99e-33 Menopause (age at onset); CRC cis rs1707322 1.000 rs12124847 chr1:46380850 T/A cg03146154 chr1:46216737 IPP 0.59 8.25 0.41 3.86e-15 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs2717559 0.542 rs10956986 chr8:143886601 C/T cg01489032 chr8:143877656 NA 0.37 6.12 0.32 2.73e-9 Urinary tract infection frequency; CRC cis rs896854 0.516 rs12679044 chr8:95891356 C/A cg09323728 chr8:95962352 TP53INP1 -0.38 -5.87 -0.31 1.06e-8 Type 2 diabetes; CRC cis rs826838 0.967 rs7136593 chr12:39128265 C/T cg13010199 chr12:38710504 ALG10B -0.41 -5.84 -0.31 1.27e-8 Heart rate; CRC cis rs2304069 0.729 rs2066934 chr5:149433596 T/G cg22760475 chr5:149380129 HMGXB3;TIGD6 0.7 8.2 0.41 5.64e-15 HIV-1 control; CRC cis rs4731207 0.596 rs1525612 chr7:124684047 G/C cg23710748 chr7:124431027 NA -0.39 -6.14 -0.32 2.35e-9 Cutaneous malignant melanoma; CRC cis rs6429082 0.508 rs4233473 chr1:235488052 C/G cg26050004 chr1:235667680 B3GALNT2 0.41 6.11 0.32 2.75e-9 Adiposity; CRC cis rs9649465 0.967 rs13244694 chr7:123329879 T/C cg03229431 chr7:123269106 ASB15 -0.36 -5.64 -0.3 3.7e-8 Migraine; CRC cis rs2243480 1.000 rs7794661 chr7:65389730 T/C cg12463550 chr7:65579703 CRCP 0.62 5.91 0.31 8.39e-9 Diabetic kidney disease; CRC cis rs1552244 0.882 rs13074282 chr3:10024699 T/G cg10729496 chr3:10149963 C3orf24 0.48 6.25 0.33 1.25e-9 Alzheimer's disease; CRC cis rs7552404 1.000 rs7548962 chr1:76139266 G/A cg22875332 chr1:76189707 ACADM 0.67 9.14 0.45 6.46e-18 Blood metabolite levels;Acylcarnitine levels; CRC cis rs7568458 0.846 rs6705971 chr2:85761417 G/T cg02493740 chr2:85810744 VAMP5 0.37 5.95 0.31 6.94e-9 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); CRC cis rs7737355 0.947 rs39600 chr5:130828649 A/T cg06307176 chr5:131281290 NA 0.41 6.02 0.31 4.78e-9 Life satisfaction; CRC cis rs4862750 0.872 rs6830828 chr4:187897472 T/G cg22105103 chr4:187893119 NA 0.63 11.52 0.54 4.85e-26 Lobe attachment (rater-scored or self-reported); CRC cis rs9399137 0.507 rs13214669 chr6:135299959 T/C cg22676075 chr6:135203613 NA 0.59 8.91 0.44 3.63e-17 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; CRC cis rs6840360 0.582 rs2709823 chr4:152340446 T/C cg09659197 chr4:152720779 NA 0.33 6.53 0.34 2.52e-10 Intelligence (multi-trait analysis); CRC cis rs7666738 0.830 rs11941961 chr4:99065654 G/T cg05340658 chr4:99064831 C4orf37 0.58 8.85 0.44 5.47e-17 Colonoscopy-negative controls vs population controls; CRC cis rs7224737 1.000 rs12603327 chr17:40290552 T/C cg02450064 chr17:40260053 DHX58 -0.42 -6.13 -0.32 2.54e-9 Fibrinogen levels; CRC cis rs72781680 0.611 rs55983206 chr2:24333995 A/C cg06627628 chr2:24431161 ITSN2 -0.55 -6.46 -0.34 3.83e-10 Lymphocyte counts; CRC cis rs1153858 1.000 rs4775911 chr15:45649787 G/T cg10760299 chr15:45669010 GATM -0.49 -7.69 -0.39 1.77e-13 Homoarginine levels; CRC cis rs9916302 0.653 rs11654954 chr17:37745979 C/T cg00129232 chr17:37814104 STARD3 0.58 7.67 0.39 1.97e-13 Glomerular filtration rate (creatinine); CRC cis rs300703 0.935 rs12714403 chr2:273070 A/G cg21211680 chr2:198530 NA 0.99 8.46 0.42 8.98e-16 Blood protein levels; CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg20961037 chr17:43096356 NA 0.35 5.97 0.31 6.31e-9 Obesity-related traits; CRC cis rs951366 0.789 rs823137 chr1:205738302 C/T cg24503407 chr1:205819492 PM20D1 0.81 12.67 0.57 3.04e-30 Menarche (age at onset); CRC trans rs9858542 0.953 rs1873625 chr3:49666964 C/A cg21659725 chr3:3221576 CRBN -0.69 -9.07 -0.45 1.1e-17 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs290268 0.874 rs290994 chr9:93559515 T/A cg02608019 chr9:93564028 SYK 0.45 7.07 0.36 9.36e-12 Platelet count; CRC cis rs7927771 0.864 rs2293577 chr11:47437202 C/T cg05585544 chr11:47624801 NA 0.47 8.54 0.43 4.96e-16 Subjective well-being; CRC cis rs4660306 1.000 rs6429567 chr1:45956700 C/A cg03123370 chr1:45965343 CCDC163P;MMACHC -0.56 -7.85 -0.4 5.99e-14 Homocysteine levels; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg18436758 chr1:21113190 HP1BP3 0.38 6.82 0.35 4.33e-11 Liver disease severity in Alagille syndrome; CRC cis rs2688608 0.617 rs6480709 chr10:75479125 T/C cg23231163 chr10:75533350 FUT11 -0.37 -5.7 -0.3 2.66e-8 Inflammatory bowel disease; CRC cis rs7626444 0.647 rs844546 chr3:196475274 T/G cg12930392 chr3:196481615 PAK2 0.4 7.26 0.37 2.74e-12 Monocyte count; CRC cis rs875971 0.522 rs9530 chr7:65425894 A/G cg11764359 chr7:65958608 NA 0.51 7.69 0.39 1.74e-13 Aortic root size; CRC cis rs933688 1.000 rs6869717 chr5:90694797 G/A cg26981201 chr5:90679533 LOC100129716;ARRDC3 1.02 15.59 0.65 1.97e-41 Smoking behavior; CRC cis rs7508679 1.000 rs4804411 chr19:7222377 G/C cg00428638 chr19:7224713 INSR 0.95 19.59 0.73 3.59e-57 Hypothyroidism; CRC cis rs12760731 0.565 rs77024410 chr1:178164121 A/C cg00404053 chr1:178313656 RASAL2 1.05 10.93 0.52 6.36e-24 Obesity-related traits; CRC cis rs7264396 0.563 rs6060569 chr20:34290731 C/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.49 -6.97 -0.36 1.7e-11 Total cholesterol levels; CRC cis rs7927771 0.864 rs60075622 chr11:47449101 T/G cg05585544 chr11:47624801 NA -0.52 -9.43 -0.46 7.53e-19 Subjective well-being; CRC cis rs734999 0.933 rs4648648 chr1:2512452 G/A cg18854424 chr1:2615690 NA 0.42 7.95 0.4 3.02e-14 Ulcerative colitis; CRC cis rs7258465 0.965 rs271628 chr19:18624333 A/G cg06462663 chr19:18546047 ISYNA1 0.48 7.38 0.38 1.34e-12 Breast cancer; CRC cis rs1639906 0.729 rs17186614 chr7:2231002 G/A cg19897017 chr7:2163380 MAD1L1 -0.62 -8.34 -0.42 2.04e-15 Colonoscopy-negative controls vs population controls; CRC cis rs748404 0.697 rs555001 chr15:43545728 G/A cg02155558 chr15:43621948 ADAL;LCMT2 0.4 5.98 0.31 5.9e-9 Lung cancer; CRC cis rs1816752 0.590 rs61947036 chr13:25017682 T/C cg02811702 chr13:24901961 NA 0.47 6.5 0.34 2.96e-10 Obesity-related traits; CRC cis rs13191362 1.000 rs67840803 chr6:163049048 C/T cg21926612 chr6:163149169 PACRG;PARK2 0.97 12.34 0.56 5.08e-29 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs4700695 0.841 rs36302 chr5:65349061 T/A cg21114390 chr5:65439923 SFRS12 0.67 6.88 0.35 2.96e-11 Facial morphology (factor 19); CRC cis rs9859260 0.744 rs492349 chr3:195784192 G/A cg12923728 chr3:195709715 SDHAP1 0.48 6.54 0.34 2.35e-10 Mean corpuscular volume; CRC trans rs1941687 0.764 rs1493915 chr18:31377582 G/T cg27147174 chr7:100797783 AP1S1 -0.4 -6.62 -0.34 1.47e-10 Subjective well-being (multi-trait analysis);Subjective well-being; CRC cis rs7508679 1.000 rs7508679 chr19:7222832 A/G cg09779027 chr19:7224513 INSR 1.01 22.54 0.78 1.1e-68 Hypothyroidism; CRC cis rs1862618 0.853 rs33322 chr5:56175226 A/G cg24531977 chr5:56204891 C5orf35 -0.84 -10.92 -0.52 6.54e-24 Initial pursuit acceleration; CRC cis rs6502050 0.835 rs8065565 chr17:80115399 A/G cg19223190 chr17:80058835 NA 0.39 6.25 0.33 1.27e-9 Life satisfaction; CRC cis rs10911390 0.744 rs116730615 chr1:183652731 A/C cg11505048 chr1:183622726 RGL1;APOBEC4 0.71 6.24 0.33 1.33e-9 Systemic lupus erythematosus; CRC cis rs36715 1.000 rs36715 chr5:127562880 C/T cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.47 5.87 0.31 1.04e-8 Breast cancer; CRC cis rs6952808 0.792 rs4421257 chr7:1955152 T/C cg02951883 chr7:2050386 MAD1L1 -0.61 -10.0 -0.48 1.01e-20 Bipolar disorder and schizophrenia; CRC cis rs1697139 0.583 rs11960733 chr5:66538715 C/T cg11553311 chr5:66541588 NA 0.58 9.94 0.48 1.6e-20 Breast cancer; CRC cis rs7249142 0.562 rs12980955 chr19:19283646 T/C cg26504305 chr19:19281019 LOC729991-MEF2B;MEF2B -0.41 -8.17 -0.41 6.77e-15 IgG glycosylation; CRC cis rs7104764 0.507 rs7111364 chr11:258542 G/C cg00562011 chr11:252351 PSMD13 -0.54 -6.33 -0.33 8.18e-10 Menarche (age at onset); CRC cis rs62458065 1.000 rs10250808 chr7:32466153 T/C cg20159608 chr7:32802032 NA -0.5 -6.31 -0.33 8.83e-10 Metabolite levels (HVA/MHPG ratio); CRC cis rs9486719 1.000 rs2499804 chr6:96861216 A/G cg18709589 chr6:96969512 KIAA0776 0.5 5.67 0.3 3.2e-8 Migraine;Coronary artery disease; CRC trans rs2727020 0.681 rs2866362 chr11:49379316 A/G cg03929089 chr4:120376271 NA -0.83 -14.53 -0.63 2.8e-37 Coronary artery disease; CRC cis rs7943203 0.962 rs10749918 chr11:108354874 C/G cg14761454 chr11:108092087 ATM;NPAT 0.39 5.67 0.3 3.11e-8 Red blood cell count;Mean corpuscular volume; CRC cis rs372883 0.648 rs1153292 chr21:30689195 G/T cg08807101 chr21:30365312 RNF160 -0.52 -7.3 -0.37 2.23e-12 Pancreatic cancer; CRC cis rs7113874 0.569 rs9300093 chr11:8590825 T/G cg17679104 chr11:8615758 STK33 -0.35 -5.88 -0.31 9.95e-9 Body mass index in physically active individuals;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs62432291 0.681 rs294912 chr6:159667337 A/G cg14500486 chr6:159655392 FNDC1 -0.74 -9.0 -0.44 1.91e-17 Joint mobility (Beighton score); CRC trans rs12699921 0.573 rs2723562 chr7:17846620 C/G cg02066331 chr6:17282778 RBM24 -0.36 -6.11 -0.32 2.79e-9 Fibrinogen levels; CRC cis rs2243480 1.000 rs6949812 chr7:65387101 G/A cg18252515 chr7:66147081 NA -1.08 -12.66 -0.57 3.44e-30 Diabetic kidney disease; CRC cis rs6968419 0.747 rs6953050 chr7:115888162 A/G cg02561103 chr7:115862891 TES -0.42 -6.28 -0.33 1.06e-9 Intraocular pressure; CRC cis rs9926296 0.605 rs8046243 chr16:89852133 A/G cg21285383 chr16:89894308 SPIRE2 0.36 6.19 0.32 1.81e-9 Vitiligo; CRC trans rs877282 0.945 rs11253388 chr10:787852 A/G cg22713356 chr15:30763199 NA 1.35 16.39 0.67 1.43e-44 Uric acid levels; CRC cis rs950776 0.593 rs588765 chr15:78865425 T/C cg06917634 chr15:78832804 PSMA4 -0.59 -9.21 -0.45 3.85e-18 Sudden cardiac arrest; CRC cis rs1223397 0.938 rs17700321 chr6:13280666 G/T cg07912922 chr6:13274314 PHACTR1 0.52 6.39 0.33 5.83e-10 Blood pressure; CRC trans rs35110281 0.667 rs7282122 chr21:45082365 G/A cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.4 6.44 0.33 4.33e-10 Mean corpuscular volume; CRC cis rs1953600 0.837 rs2573352 chr10:81939813 T/C cg04850286 chr10:81895943 PLAC9 0.38 6.72 0.35 7.9e-11 Sarcoidosis; CRC trans rs800082 0.501 rs9844730 chr3:144216886 T/G cg24215973 chr2:240111563 HDAC4 0.54 8.14 0.41 8.3e-15 Smoking behavior; CRC cis rs7937682 0.889 rs542424 chr11:111477698 T/C cg19812747 chr11:111475976 SIK2 -0.57 -9.75 -0.47 7e-20 Primary sclerosing cholangitis; CRC cis rs67311347 1.000 rs12630072 chr3:40517190 T/G cg24209194 chr3:40518798 ZNF619 0.41 5.7 0.3 2.6e-8 Renal cell carcinoma; CRC cis rs796364 0.806 rs203769 chr2:200900866 C/T cg25936922 chr2:200820526 C2orf60;C2orf47 -0.66 -6.42 -0.33 4.75e-10 Schizophrenia; CRC cis rs9291683 0.609 rs13149985 chr4:10028390 G/A cg00071950 chr4:10020882 SLC2A9 0.67 12.56 0.57 8.3e-30 Bone mineral density; CRC cis rs728616 0.614 rs61859209 chr10:82128309 G/A cg05935833 chr10:81318306 SFTPA2 -0.58 -7.02 -0.36 1.28e-11 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs2067615 0.524 rs9804754 chr12:107083031 G/A cg15890332 chr12:107067104 RFX4 0.32 5.7 0.3 2.64e-8 Heart rate; CRC cis rs11212617 1.000 rs609429 chr11:108196509 G/C cg14761454 chr11:108092087 ATM;NPAT 0.43 6.55 0.34 2.19e-10 Response to metformin in type 2 diabetes (glycemic); CRC cis rs921968 0.540 rs10190250 chr2:219457731 C/T cg02176678 chr2:219576539 TTLL4 -0.57 -9.05 -0.45 1.24e-17 Mean corpuscular hemoglobin concentration; CRC cis rs13108904 0.935 rs1732100 chr4:1281761 C/T cg24560729 chr4:1342394 KIAA1530 -0.32 -5.85 -0.31 1.17e-8 Obesity-related traits; CRC cis rs3091242 0.967 rs3093614 chr1:25677844 T/A cg20684491 chr1:25596433 NA -0.44 -7.88 -0.4 4.79e-14 Erythrocyte sedimentation rate; CRC cis rs1448094 0.791 rs61929394 chr12:86331541 C/A cg25456477 chr12:86230367 RASSF9 0.34 5.77 0.3 1.82e-8 Major depressive disorder; CRC cis rs2243480 0.803 rs423187 chr7:65509499 G/C cg25985355 chr7:65971099 NA -0.56 -6.28 -0.33 1.04e-9 Diabetic kidney disease; CRC cis rs951366 0.789 rs823094 chr1:205689807 G/T cg17178900 chr1:205818956 PM20D1 -0.64 -9.62 -0.47 1.81e-19 Menarche (age at onset); CRC cis rs875971 1.000 rs10257427 chr7:65743208 T/C cg00343986 chr7:65444356 GUSB -0.44 -6.42 -0.33 4.74e-10 Aortic root size; CRC cis rs4588572 0.643 rs2012562 chr5:77768088 T/A cg11446398 chr5:77624930 NA 0.46 6.33 0.33 8.15e-10 Triglycerides; CRC cis rs7618915 0.547 rs2590846 chr3:52692359 C/G cg18404041 chr3:52824283 ITIH1 -0.43 -8.81 -0.44 7.22e-17 Bipolar disorder; CRC cis rs1552244 0.626 rs2886396 chr3:10037670 C/T cg10729496 chr3:10149963 C3orf24 0.49 6.34 0.33 7.69e-10 Alzheimer's disease; CRC cis rs7215564 0.908 rs56078934 chr17:78658849 A/C cg09596252 chr17:78655493 RPTOR 0.53 5.66 0.3 3.26e-8 Myopia (pathological); CRC cis rs853679 0.517 rs17774663 chr6:28120898 G/A cg02631126 chr6:28058918 ZSCAN12L1 0.29 5.91 0.31 8.38e-9 Depression; CRC cis rs9517320 0.967 rs9517317 chr13:99125711 G/C cg07423050 chr13:99094983 FARP1 0.41 6.6 0.34 1.63e-10 Longevity; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg16761550 chr16:3029823 PKMYT1 0.43 6.18 0.32 1.91e-9 Thyroid stimulating hormone; CRC cis rs875971 0.651 rs313829 chr7:65552497 A/G cg02869306 chr7:64672164 INTS4L1 0.44 6.86 0.35 3.53e-11 Aortic root size; CRC cis rs9894429 0.966 rs10871499 chr17:79589006 G/A cg13777783 chr17:79615861 NA -0.3 -5.72 -0.3 2.44e-8 Eye color traits; CRC cis rs7208859 0.623 rs73271842 chr17:29137155 T/C cg01831904 chr17:28903510 LRRC37B2 -0.62 -6.41 -0.33 5.13e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs13108904 0.517 rs4974551 chr4:1336410 C/A cg20092199 chr4:1342459 KIAA1530 0.45 7.32 0.37 1.95e-12 Obesity-related traits; CRC cis rs6724607 1.000 rs10165399 chr2:191441595 A/G cg21644426 chr2:191273491 MFSD6 0.47 6.44 0.33 4.23e-10 Pulse pressure; CRC cis rs1949733 0.701 rs2631735 chr4:8476118 A/G cg11789530 chr4:8429930 ACOX3 0.74 10.45 0.5 2.97e-22 Response to antineoplastic agents; CRC cis rs4731207 0.596 rs12113765 chr7:124589684 G/C cg23710748 chr7:124431027 NA -0.38 -6.08 -0.32 3.35e-9 Cutaneous malignant melanoma; CRC cis rs7809950 1.000 rs7786801 chr7:107085889 C/T cg23024343 chr7:107201750 COG5 -0.61 -8.76 -0.43 1.06e-16 Coronary artery disease; CRC cis rs9303401 0.659 rs12948133 chr17:56673602 T/C cg10487724 chr17:56770010 TEX14;RAD51C 0.79 9.55 0.47 3.04e-19 Cognitive test performance; CRC trans rs329674 0.516 rs329650 chr11:133765897 C/T cg05324519 chr17:62770765 LOC146880 0.46 6.04 0.32 4.24e-9 Bipolar disorder; CRC cis rs1799949 0.965 rs34633610 chr17:41419385 A/G cg05368731 chr17:41323189 NBR1 0.65 9.39 0.46 1.03e-18 Menopause (age at onset); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg03352657 chr17:26684557 POLDIP2;TMEM199 0.46 8.12 0.41 9.42e-15 Liver disease severity in Alagille syndrome; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg06772644 chr1:40997203 ZNF684 0.39 6.22 0.32 1.53e-9 Liver disease severity in Alagille syndrome; CRC cis rs2732480 0.500 rs2450986 chr12:48661688 G/A cg24011408 chr12:48396354 COL2A1 0.45 6.32 0.33 8.27e-10 Hemoglobin concentration;Red blood cell count;Hematocrit; CRC cis rs9486719 1.000 rs12191653 chr6:96903898 T/C cg18709589 chr6:96969512 KIAA0776 -0.51 -5.74 -0.3 2.15e-8 Migraine;Coronary artery disease; CRC trans rs7615952 0.546 rs11717632 chr3:125321130 G/C cg16558177 chr4:4109446 NA -0.56 -6.43 -0.33 4.42e-10 Blood pressure (smoking interaction); CRC cis rs11997175 0.624 rs17700425 chr8:33691467 T/G cg04338863 chr8:33670619 NA 0.44 6.9 0.36 2.68e-11 Body mass index; CRC trans rs1656966 1.000 rs1656966 chr3:186466252 C/T cg18802567 chr5:171433913 FBXW11 0.4 6.1 0.32 3.01e-9 Myopia (pathological); CRC trans rs10982213 0.830 rs2274163 chr9:117188714 C/T cg07584320 chr11:94964503 SESN3 0.42 6.58 0.34 1.91e-10 Interleukin-6 levels; CRC trans rs333332 1.000 rs333332 chr3:124328494 C/T cg08451243 chr11:1273788 MUC5B 0.41 6.51 0.34 2.89e-10 Heschl's gyrus morphology; CRC cis rs736408 0.527 rs2577831 chr3:52628056 C/A cg18099408 chr3:52552593 STAB1 -0.54 -9.8 -0.48 4.49e-20 Bipolar disorder; CRC trans rs13046373 0.905 rs4816372 chr21:32077414 A/T cg01779806 chr5:160279389 ATP10B -0.38 -5.99 -0.31 5.44e-9 HDL cholesterol; CRC cis rs13108904 0.967 rs2293635 chr4:1291791 A/G cg21620606 chr4:1342894 KIAA1530 0.34 5.65 0.3 3.53e-8 Obesity-related traits; CRC cis rs1003719 0.715 rs2051398 chr21:38550258 C/T cg10648535 chr21:38446584 PIGP;TTC3 0.48 6.72 0.35 8.11e-11 Eye color traits; CRC trans rs2303319 0.504 rs58622044 chr2:162596287 A/G cg22627826 chr19:1240265 ATP5D -0.72 -6.18 -0.32 1.86e-9 Cognitive function; CRC cis rs7208859 0.673 rs79541516 chr17:29240583 C/T cg14008862 chr17:28927542 LRRC37B2 0.56 5.8 0.3 1.52e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs7605827 0.897 rs9973344 chr2:15632583 G/T cg19274914 chr2:15703543 NA 0.4 6.04 0.32 4.17e-9 Educational attainment (years of education); CRC cis rs10751667 0.666 rs6597960 chr11:977036 C/T cg06064525 chr11:970664 AP2A2 -0.3 -6.11 -0.32 2.78e-9 Alzheimer's disease (late onset); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg27010576 chr16:21964792 UQCRC2 0.48 6.8 0.35 4.99e-11 Response to antipsychotic treatment; CRC cis rs2153535 0.580 rs1932283 chr6:8477661 C/T cg21535247 chr6:8435926 SLC35B3 0.5 7.55 0.38 4.42e-13 Motion sickness; CRC cis rs2075371 0.965 rs1862049 chr7:133978344 A/T cg02659138 chr7:134003124 SLC35B4 0.38 6.51 0.34 2.85e-10 Mean platelet volume; CRC cis rs3791406 0.654 rs3791409 chr2:240030606 C/G cg14550559 chr2:240039617 HDAC4 -0.47 -6.88 -0.35 3.04e-11 Skin aging (microtopography measurement); CRC cis rs1552244 0.608 rs3732962 chr3:10048951 T/C cg16606324 chr3:10149918 C3orf24 0.48 7.03 0.36 1.19e-11 Alzheimer's disease; CRC cis rs11105298 0.891 rs10858899 chr12:89923811 G/C cg00757033 chr12:89920650 WDR51B 0.36 5.98 0.31 5.84e-9 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; CRC cis rs2197308 0.623 rs1672426 chr12:38118671 C/T cg13010199 chr12:38710504 ALG10B -0.43 -6.14 -0.32 2.36e-9 Morning vs. evening chronotype; CRC cis rs853679 0.517 rs9380049 chr6:28048535 A/G cg12273811 chr6:28175739 NA 0.69 8.83 0.44 6.17e-17 Depression; CRC cis rs6951245 1.000 rs78143408 chr7:1096846 G/A cg24642844 chr7:1081250 C7orf50 -0.78 -9.44 -0.46 7.23e-19 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg04355093 chr4:85887382 WDFY3;C4orf12 -0.41 -6.16 -0.32 2.17e-9 Myopia (pathological); CRC cis rs9322193 0.887 rs9505824 chr6:149954799 A/G cg13206674 chr6:150067644 NUP43 0.65 9.76 0.47 6.33e-20 Lung cancer; CRC cis rs728616 0.717 rs17098169 chr10:81816134 C/T cg11900509 chr10:81946545 ANXA11 0.53 5.78 0.3 1.76e-8 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs4718428 0.705 rs13231140 chr7:66361618 C/G cg12165864 chr7:66369176 NA -0.42 -5.78 -0.3 1.75e-8 Corneal structure; CRC cis rs7618915 0.501 rs34739010 chr3:52766122 A/G cg18404041 chr3:52824283 ITIH1 -0.41 -8.4 -0.42 1.36e-15 Bipolar disorder; CRC cis rs71403859 0.502 rs17345863 chr16:71523261 C/T cg08717414 chr16:71523259 ZNF19 -1.0 -10.42 -0.5 3.76e-22 Post bronchodilator FEV1; CRC cis rs11741688 0.597 rs6880072 chr5:178334480 G/C cg20935368 chr5:178288625 ZNF354B 0.43 7.03 0.36 1.16e-11 Sleep duration; CRC cis rs12476592 0.543 rs262532 chr2:63906020 G/A cg10828910 chr2:63850056 LOC388955 0.5 6.3 0.33 9.56e-10 Childhood ear infection; CRC cis rs1971762 0.545 rs10747676 chr12:54049930 T/C cg06632207 chr12:54070931 ATP5G2 0.45 7.69 0.39 1.73e-13 Height; CRC trans rs6703335 0.870 rs10803142 chr1:243598234 A/G cg05954884 chr1:155279053 FDPS 0.43 6.01 0.31 4.98e-9 Schizophrenia;Schizophrenia, schizoaffective disorder or bipolar disorder; CRC cis rs7727544 1.000 rs7727038 chr5:131590257 C/T cg11843238 chr5:131593191 PDLIM4 0.36 6.97 0.36 1.77e-11 Blood metabolite levels; CRC cis rs9322193 0.923 rs3924871 chr6:149983216 G/A cg00933542 chr6:150070202 PCMT1 0.31 6.38 0.33 6.16e-10 Lung cancer; CRC cis rs6502050 0.805 rs7406137 chr17:80084465 T/C cg02741985 chr17:80059408 CCDC57 -0.43 -7.0 -0.36 1.43e-11 Life satisfaction; CRC cis rs6840360 0.593 rs2089811 chr4:152685171 C/T cg09659197 chr4:152720779 NA -0.42 -8.66 -0.43 2.18e-16 Intelligence (multi-trait analysis); CRC cis rs1670533 1.000 rs62294756 chr4:1097676 G/A cg27284194 chr4:1044797 NA -0.51 -6.37 -0.33 6.44e-10 Recombination rate (females); CRC cis rs7208859 0.623 rs9899268 chr17:29150255 T/C cg01831904 chr17:28903510 LRRC37B2 -0.66 -6.7 -0.35 9.13e-11 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs13118159 0.550 rs2336081 chr4:1350322 A/G cg02475777 chr4:1388615 CRIPAK -0.48 -6.13 -0.32 2.49e-9 Longevity; CRC cis rs755249 0.567 rs16825921 chr1:39649198 A/T cg18385671 chr1:39797026 MACF1 -0.41 -5.93 -0.31 7.46e-9 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs9549328 0.520 rs36144023 chr13:113616592 T/C cg20742385 chr13:113633654 MCF2L 0.55 9.39 0.46 1.01e-18 Systolic blood pressure; CRC cis rs3736485 0.934 rs17609924 chr15:51911592 G/A cg08986416 chr15:51914746 DMXL2 -0.45 -6.33 -0.33 8.13e-10 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs8078723 1.000 rs8070454 chr17:38160754 C/T cg17467752 chr17:38218738 THRA 0.73 11.82 0.55 4.15e-27 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); CRC cis rs1568889 1.000 rs12808162 chr11:28067027 A/G cg06544937 chr11:28130018 METT5D1;KIF18A 0.78 11.19 0.53 7.36e-25 Bipolar disorder; CRC cis rs546131 0.928 rs499183 chr11:34836678 A/G cg06937548 chr11:34938143 PDHX;APIP 0.39 5.9 0.31 8.8e-9 Lung disease severity in cystic fibrosis; CRC cis rs2462686 0.965 rs1534151 chr7:45984645 A/G cg15898840 chr7:45960834 IGFBP3 -0.39 -5.83 -0.31 1.29e-8 Major depressive disorder; CRC cis rs2712184 0.873 rs1548945 chr2:217665788 T/C cg05032264 chr2:217675019 NA -0.33 -5.71 -0.3 2.56e-8 Glomerular filtration rate;Glomerular filtration rate in non diabetics (creatinine); CRC cis rs7746199 0.736 rs17693963 chr6:27710165 A/C cg12185399 chr6:27640341 NA 0.82 5.85 0.31 1.21e-8 Gait speed in old age;Autism spectrum disorder or schizophrenia; CRC cis rs7725052 0.605 rs10941510 chr5:40462426 T/C cg09067459 chr5:40385259 NA 0.4 6.57 0.34 1.94e-10 Pediatric autoimmune diseases; CRC cis rs875971 0.862 rs57866200 chr7:65565392 A/G cg11764359 chr7:65958608 NA -0.58 -8.83 -0.44 6.38e-17 Aortic root size; CRC cis rs758324 0.812 rs13170176 chr5:131138736 G/C cg25547332 chr5:131281432 NA 0.36 5.72 0.3 2.34e-8 Alzheimer's disease in APOE e4- carriers; CRC cis rs644799 0.710 rs12272061 chr11:95524067 G/T cg03916912 chr11:95522834 CEP57;FAM76B 0.85 15.84 0.66 2.15e-42 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs1218582 0.772 rs4845689 chr1:154885524 A/G cg06221963 chr1:154839813 KCNN3 -0.76 -15.38 -0.65 1.3e-40 Prostate cancer; CRC cis rs9916302 0.904 rs8079355 chr17:37473018 G/A cg03013999 chr17:37608204 MED1 -0.48 -7.51 -0.38 5.62e-13 Glomerular filtration rate (creatinine); CRC cis rs853679 0.517 rs4711165 chr6:28115184 T/G cg15786705 chr6:28176104 NA 0.78 9.83 0.48 3.57e-20 Depression; CRC cis rs1223397 0.651 rs957175 chr6:13311243 C/T cg07912922 chr6:13274314 PHACTR1 0.38 6.0 0.31 5.21e-9 Blood pressure; CRC cis rs4972806 0.814 rs4246626 chr2:177046430 A/C cg14324370 chr2:177042789 NA 0.8 13.08 0.58 9.34e-32 IgG glycosylation; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg02445447 chr2:106015594 FHL2 0.39 6.09 0.32 3.13e-9 Liver disease severity in Alagille syndrome; CRC cis rs3751196 0.808 rs79014697 chr12:104213856 G/T cg02344784 chr12:104178138 NT5DC3 0.71 7.54 0.38 4.58e-13 Sense of smell; CRC cis rs6502050 0.529 rs35585236 chr17:80116641 T/C cg11859384 chr17:80120422 CCDC57 -0.38 -6.0 -0.31 5.13e-9 Life satisfaction; CRC trans rs1455244 0.700 rs7229302 chr18:11508904 G/T cg07734359 chr17:618044 VPS53 0.4 6.04 0.32 4.08e-9 Schizophrenia; CRC cis rs11098499 0.863 rs3822195 chr4:120471660 C/T cg09307838 chr4:120376055 NA 0.67 10.2 0.49 2.1e-21 Corneal astigmatism; CRC trans rs2797160 1.000 rs2797160 chr6:126010116 A/G cg05039488 chr6:79577232 IRAK1BP1 0.49 7.29 0.37 2.25e-12 Endometrial cancer; CRC cis rs11098499 0.739 rs7441137 chr4:120133221 G/T cg24375607 chr4:120327624 NA -0.47 -7.75 -0.39 1.14e-13 Corneal astigmatism; CRC cis rs7618915 0.501 rs11714030 chr3:52765882 C/T cg08222913 chr3:52553049 STAB1 -0.33 -6.08 -0.32 3.4e-9 Bipolar disorder; CRC cis rs7811142 0.830 rs6979910 chr7:99940630 A/C cg00814883 chr7:100076585 TSC22D4 -0.68 -8.61 -0.43 3.05e-16 Platelet count; CRC cis rs3768617 0.740 rs28533496 chr1:183019885 G/T ch.1.3577855R chr1:183094577 LAMC1 0.61 8.99 0.44 1.96e-17 Fuchs's corneal dystrophy; CRC cis rs875971 0.505 rs1167386 chr7:65513096 G/A cg18876405 chr7:65276391 NA -0.63 -11.38 -0.53 1.63e-25 Aortic root size; CRC cis rs9911578 0.967 rs57869245 chr17:57106630 A/G cg12560992 chr17:57184187 TRIM37 -0.87 -16.13 -0.66 1.52e-43 Intelligence (multi-trait analysis); CRC cis rs2576037 0.796 rs2571033 chr18:44578552 C/T cg07416455 chr18:44543612 TCEB3CL;KATNAL2 0.42 6.12 0.32 2.71e-9 Personality dimensions; CRC cis rs478304 0.627 rs1073602 chr11:65455386 G/C cg27068330 chr11:65405492 SIPA1 -0.67 -10.02 -0.48 8.37e-21 Acne (severe); CRC cis rs6502050 0.765 rs6502074 chr17:80121776 T/C cg19223190 chr17:80058835 NA 0.4 6.33 0.33 8.04e-10 Life satisfaction; CRC cis rs9549367 0.789 rs9549718 chr13:113909822 A/G cg18105134 chr13:113819100 PROZ -0.74 -10.43 -0.5 3.45e-22 Platelet distribution width; CRC cis rs6502050 0.699 rs9901808 chr17:80107814 C/T cg02741985 chr17:80059408 CCDC57 0.42 7.02 0.36 1.25e-11 Life satisfaction; CRC cis rs72781680 0.560 rs72781698 chr2:24271506 C/T cg06627628 chr2:24431161 ITSN2 -0.53 -5.87 -0.31 1.07e-8 Lymphocyte counts; CRC cis rs1008375 1.000 rs7671752 chr4:17661398 C/T cg16339924 chr4:17578868 LAP3 0.55 7.2 0.37 4.21e-12 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs1018836 0.828 rs12547016 chr8:91563847 T/C cg16814680 chr8:91681699 NA -0.63 -9.81 -0.48 4.18e-20 Ejection fraction in Tripanosoma cruzi seropositivity; CRC cis rs1153858 1.000 rs1820518 chr15:45694579 C/T cg21132104 chr15:45694354 SPATA5L1 0.63 8.94 0.44 2.92e-17 Homoarginine levels; CRC trans rs1455244 0.700 rs7229302 chr18:11508904 G/T cg03241287 chr5:118324324 DTWD2 0.41 6.05 0.32 3.88e-9 Schizophrenia; CRC trans rs8073060 0.963 rs35614987 chr17:33869466 A/C cg19694781 chr19:47549865 TMEM160 0.54 7.91 0.4 3.94e-14 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; CRC cis rs17376456 0.825 rs13357713 chr5:93145423 T/C cg25358565 chr5:93447407 FAM172A 1.0 9.8 0.48 4.7e-20 Diabetic retinopathy; CRC cis rs7607369 0.559 rs4674342 chr2:219660064 T/C cg02176678 chr2:219576539 TTLL4 -0.38 -6.03 -0.32 4.44e-9 Red blood cell count;Amyotrophic lateral sclerosis; CRC cis rs6502050 0.835 rs4789722 chr17:80151881 G/A cg22110888 chr17:80059540 CCDC57 0.39 6.25 0.33 1.27e-9 Life satisfaction; CRC cis rs2281845 0.965 rs3738263 chr1:201083506 A/G cg08885800 chr1:201084119 NA 0.48 8.91 0.44 3.5e-17 Permanent tooth development; CRC cis rs7772486 0.817 rs2748491 chr6:146327759 T/C cg13319975 chr6:146136371 FBXO30 -0.38 -5.72 -0.3 2.38e-8 Lobe attachment (rater-scored or self-reported); CRC cis rs6951245 0.872 rs76161580 chr7:1100307 G/T cg26224354 chr7:1096374 C7orf50;GPR146 -0.93 -12.05 -0.55 5.9e-28 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs2839186 0.526 rs59977673 chr21:47922091 C/T cg05896524 chr21:47604654 C21orf56 0.46 6.88 0.35 3.03e-11 Testicular germ cell tumor; CRC cis rs1552244 0.882 rs3755783 chr3:10029289 A/G cg18598329 chr3:10140678 FANCD2;C3orf24 -0.75 -9.0 -0.44 1.8e-17 Alzheimer's disease; CRC cis rs2204008 0.694 rs1672436 chr12:38132547 G/T cg13010199 chr12:38710504 ALG10B -0.41 -5.99 -0.31 5.54e-9 Bladder cancer; CRC cis rs75804782 1.000 rs75804782 chr2:239316043 T/C cg18131467 chr2:239335373 ASB1 -0.67 -5.71 -0.3 2.57e-8 Morning vs. evening chronotype;Chronotype; CRC cis rs10771431 0.967 rs7137443 chr12:9372029 C/T cg22349387 chr12:9600060 DDX12 -0.36 -5.74 -0.3 2.19e-8 Breast size; CRC trans rs7615952 0.733 rs13314847 chr3:125644788 C/T cg00769240 chr8:12517080 NA -0.57 -7.05 -0.36 1.04e-11 Blood pressure (smoking interaction); CRC cis rs11711311 1.000 rs9830978 chr3:113455940 A/C cg15478005 chr3:113465772 ATP6V1A;NAA50 0.45 6.15 0.32 2.19e-9 IgG glycosylation; CRC trans rs7267979 0.844 rs6083824 chr20:25363057 G/A cg17903999 chr18:56338584 MALT1 0.42 6.68 0.35 1.05e-10 Liver enzyme levels (alkaline phosphatase); CRC cis rs3812762 0.871 rs11042068 chr11:8815599 C/G cg00186954 chr11:8933980 ST5;C11orf17 -0.42 -6.78 -0.35 5.52e-11 Hypospadias; CRC cis rs6089584 0.888 rs6061973 chr20:60610870 C/T cg12751644 chr20:60527061 NA -0.4 -6.32 -0.33 8.66e-10 Body mass index; CRC cis rs7586879 0.575 rs6721750 chr2:25128719 A/G cg22495460 chr2:25135724 ADCY3 -0.87 -17.39 -0.69 1.75e-48 Body mass index; CRC cis rs7618915 0.547 rs68021750 chr3:52624769 G/A cg08222913 chr3:52553049 STAB1 -0.34 -6.21 -0.32 1.64e-9 Bipolar disorder; CRC cis rs13108904 0.870 rs4974577 chr4:1266046 G/A cg19318889 chr4:1322082 MAEA 0.41 5.78 0.3 1.71e-8 Obesity-related traits; CRC cis rs11098499 0.909 rs10026736 chr4:120384322 G/C cg24375607 chr4:120327624 NA 0.51 7.73 0.39 1.36e-13 Corneal astigmatism; CRC trans rs116095464 0.542 rs28650039 chr5:273954 C/A cg00938859 chr5:1591904 SDHAP3 0.71 7.6 0.39 3.16e-13 Breast cancer; CRC cis rs2361718 0.967 rs2361719 chr17:78103403 A/G cg20811857 chr17:78079795 GAA 0.37 6.19 0.32 1.78e-9 Yeast infection; CRC cis rs11645898 0.748 rs11647889 chr16:72052034 C/G cg14768367 chr16:72042858 DHODH -0.74 -7.66 -0.39 2.1e-13 Blood protein levels; CRC cis rs2857891 0.695 rs2857896 chr11:6982825 A/T cg04053776 chr11:6947353 ZNF215 0.38 5.83 0.31 1.35e-8 Response to cytadine analogues (cytosine arabinoside); CRC cis rs9322193 0.683 rs113281309 chr6:150108425 T/G cg07701084 chr6:150067640 NUP43 0.47 6.61 0.34 1.51e-10 Lung cancer; CRC cis rs629535 0.862 rs655028 chr8:70049047 T/C cg26132723 chr8:70041827 NA 0.35 5.72 0.3 2.41e-8 Dupuytren's disease; CRC cis rs7224685 0.501 rs781825 chr17:3966064 A/G cg05562828 chr17:3906858 NA 0.67 12.41 0.56 2.83e-29 Type 2 diabetes; CRC cis rs34779708 0.966 rs12775799 chr10:35488264 C/T cg03585969 chr10:35415529 CREM 0.55 7.4 0.38 1.17e-12 Inflammatory bowel disease;Crohn's disease; CRC cis rs2635047 0.638 rs16954921 chr18:44610526 G/T cg19077165 chr18:44547161 KATNAL2 -0.42 -6.51 -0.34 2.79e-10 Educational attainment; CRC cis rs832540 0.669 rs173764 chr5:56198920 C/T cg12311346 chr5:56204834 C5orf35 -0.55 -8.23 -0.41 4.54e-15 Coronary artery disease; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg25503565 chr17:38264529 NA -0.42 -6.87 -0.35 3.28e-11 Myopia (pathological); CRC cis rs7264396 0.790 rs2425115 chr20:34322418 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.64 -10.65 -0.51 5.8e-23 Total cholesterol levels; CRC cis rs2235642 0.750 rs2974845 chr16:1648162 T/C cg26528668 chr16:1614120 IFT140 0.38 5.88 0.31 1.03e-8 Coronary artery disease; CRC cis rs6570726 0.935 rs372378 chr6:145816227 A/G cg05347473 chr6:146136440 FBXO30 0.37 5.93 0.31 7.63e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs6942756 1.000 rs17168512 chr7:128955033 A/G cg02491457 chr7:128862824 NA -0.75 -10.19 -0.49 2.26e-21 White matter hyperintensity burden; CRC cis rs8180040 0.966 rs2062278 chr3:47416761 C/T cg10298567 chr3:47292165 KIF9 -0.38 -6.14 -0.32 2.39e-9 Colorectal cancer; CRC cis rs3924048 0.574 rs34494202 chr1:12612868 G/A cg00291366 chr1:12616550 NA 0.59 10.73 0.51 3.06e-23 Optic cup area; CRC cis rs769267 0.965 rs2965191 chr19:19453521 T/G cg20644253 chr19:19431407 KIAA0892;SF4 -0.41 -5.74 -0.3 2.13e-8 Tonsillectomy; CRC cis rs10979 1.000 rs9386032 chr6:143887492 A/G cg25407410 chr6:143891975 LOC285740 -0.83 -13.54 -0.6 1.73e-33 Hypospadias; CRC cis rs1577917 0.771 rs9362239 chr6:86429263 G/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A 0.58 8.2 0.41 5.45e-15 Response to antipsychotic treatment; CRC cis rs13108904 0.517 rs4974551 chr4:1336410 C/A cg02018176 chr4:1364513 KIAA1530 0.39 5.73 0.3 2.22e-8 Obesity-related traits; CRC cis rs10274279 0.660 rs9638055 chr7:157379914 A/G cg26886268 chr7:157387156 PTPRN2 -0.46 -6.43 -0.33 4.5e-10 Myopia (pathological); CRC cis rs798554 0.679 rs1614791 chr7:2888057 G/T cg19346786 chr7:2764209 NA -0.39 -6.59 -0.34 1.73e-10 Height; CRC cis rs4750440 0.637 rs2457859 chr10:14032099 T/G cg04819048 chr10:14014548 FRMD4A 0.37 6.11 0.32 2.82e-9 Adiponectin levels; CRC cis rs5753618 0.583 rs2273251 chr22:31843567 G/C cg22777020 chr22:31556080 RNF185 0.48 5.76 0.3 1.9e-8 Colorectal cancer; CRC cis rs10791097 0.739 rs11222358 chr11:130730497 G/A cg12179176 chr11:130786555 SNX19 0.69 11.25 0.53 4.54e-25 Autism spectrum disorder or schizophrenia;Schizophrenia; CRC cis rs738322 0.600 rs5995542 chr22:38558141 C/T cg25457927 chr22:38595422 NA -0.32 -6.6 -0.34 1.6e-10 Cutaneous nevi; CRC cis rs883565 0.502 rs9839582 chr3:38943120 G/A cg01426195 chr3:39028469 NA 0.38 6.37 0.33 6.34e-10 Handedness; CRC cis rs7177699 0.525 rs56076311 chr15:79115120 A/G cg15571903 chr15:79123663 NA -0.3 -5.96 -0.31 6.61e-9 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; CRC cis rs4719841 0.662 rs6980357 chr7:25994009 A/G cg24254488 chr7:25991654 NA 0.29 6.02 0.31 4.75e-9 Triglyceride levels; CRC cis rs6687430 0.543 rs7512495 chr1:10631237 C/T cg17425144 chr1:10567563 PEX14 0.48 9.43 0.46 7.45e-19 Hand grip strength; CRC cis rs9354308 0.866 rs2814092 chr6:66547346 C/G cg07460842 chr6:66804631 NA 0.46 5.68 0.3 2.95e-8 Metabolite levels; CRC cis rs1957429 0.522 rs73279816 chr14:65348375 G/A cg23373153 chr14:65346875 NA -0.65 -5.89 -0.31 9.49e-9 Pediatric areal bone mineral density (radius); CRC cis rs3772130 0.564 rs9817555 chr3:121406327 G/A cg20356878 chr3:121714668 ILDR1 0.55 10.17 0.49 2.62e-21 Cognitive performance; CRC cis rs4243830 0.850 rs12410405 chr1:6581283 C/G cg22792644 chr1:6614718 TAS1R1;NOL9 0.82 10.91 0.52 7.22e-24 Body mass index; CRC cis rs11645898 0.872 rs55955726 chr16:72213691 G/C cg14768367 chr16:72042858 DHODH -0.59 -6.54 -0.34 2.4e-10 Blood protein levels; CRC cis rs7264396 0.616 rs6142476 chr20:34581216 T/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.54 -8.58 -0.43 3.79e-16 Total cholesterol levels; CRC cis rs6088590 1.000 rs2236270 chr20:33523155 G/T cg24642439 chr20:33292090 TP53INP2 0.53 9.14 0.45 6.4e-18 Coronary artery disease; CRC cis rs7208859 0.673 rs73265624 chr17:29232066 G/A cg01831904 chr17:28903510 LRRC37B2 -0.56 -5.83 -0.31 1.35e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs67311347 0.544 rs2278929 chr3:40351008 C/G cg09455208 chr3:40491958 NA -0.29 -5.86 -0.31 1.15e-8 Renal cell carcinoma; CRC cis rs1707322 0.928 rs7527244 chr1:46368772 A/G cg03146154 chr1:46216737 IPP 0.52 7.15 0.37 5.72e-12 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg04136173 chr3:38065951 PLCD1 0.38 6.07 0.32 3.44e-9 Liver disease severity in Alagille syndrome; CRC cis rs1451375 1.000 rs2329340 chr7:50620229 C/T cg18232548 chr7:50535776 DDC 0.48 6.82 0.35 4.43e-11 Malaria; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg04698434 chr2:25265145 EFR3B 0.36 6.11 0.32 2.75e-9 Liver disease severity in Alagille syndrome; CRC trans rs72766638 0.848 rs11789898 chr9:136925663 A/C cg09836344 chr4:1243392 C4orf42;CTBP1 0.55 6.14 0.32 2.33e-9 Mosquito bite size; CRC cis rs17001868 0.527 rs11913132 chr22:40778778 A/G cg07138101 chr22:40742427 ADSL 0.48 6.76 0.35 6.35e-11 Mammographic density (dense area); CRC cis rs7811142 1.000 rs1000215 chr7:100004543 A/G cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.03 14.78 0.63 2.93e-38 Platelet count; CRC cis rs10911251 0.508 rs10797854 chr1:183106739 G/A ch.1.3577855R chr1:183094577 LAMC1 0.8 13.8 0.61 1.68e-34 Colorectal cancer; CRC cis rs2077654 0.556 rs4756888 chr11:17442658 T/C cg25308976 chr11:17434268 ABCC8 0.6 6.9 0.36 2.68e-11 Gout; CRC trans rs7267979 0.932 rs6115214 chr20:25557426 C/T cg17903999 chr18:56338584 MALT1 0.43 6.96 0.36 1.85e-11 Liver enzyme levels (alkaline phosphatase); CRC cis rs10479542 0.784 rs6601050 chr5:178986261 C/G cg19626725 chr5:178986131 RUFY1 -0.38 -7.72 -0.39 1.39e-13 Lung cancer; CRC trans rs1814175 0.647 rs61306292 chr11:49856040 G/C cg11707556 chr5:10655725 ANKRD33B -0.43 -7.93 -0.4 3.43e-14 Height; CRC trans rs492478 0.892 rs80288101 chr5:3929135 A/G cg09199442 chr11:28132951 METT5D1 -0.7 -6.1 -0.32 3.05e-9 Cognitive performance; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg06590470 chr9:34523253 ENHO 0.5 6.94 0.36 2.13e-11 Response to antipsychotic treatment; CRC cis rs763014 0.966 rs4984675 chr16:670117 T/C cg04497992 chr16:616212 NHLRC4 0.42 6.56 0.34 2.04e-10 Height; CRC cis rs9768139 0.733 rs12698208 chr7:158117575 C/T cg06219351 chr7:158114137 PTPRN2 -0.5 -7.43 -0.38 9.17e-13 Calcium levels; CRC cis rs6860806 0.661 rs2136188 chr5:131577514 A/G cg18301423 chr5:131593218 PDLIM4 -0.37 -6.86 -0.35 3.34e-11 Breast cancer; CRC cis rs17152411 0.947 rs733400 chr10:126594340 G/A cg07906193 chr10:126599966 NA 0.58 6.52 0.34 2.69e-10 Height; CRC cis rs7113874 0.524 rs9704586 chr11:8578530 T/G cg17679104 chr11:8615758 STK33 -0.35 -5.86 -0.31 1.14e-8 Body mass index in physically active individuals;Body mass index (joint analysis main effects and physical activity interaction); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg07804711 chr19:46142647 MIR330;EML2 0.45 6.57 0.34 2.01e-10 Response to antipsychotic treatment; CRC trans rs8002861 0.641 rs2028813 chr13:44422126 G/T cg17145862 chr1:211918768 LPGAT1 0.56 9.41 0.46 8.55e-19 Leprosy; CRC cis rs9467603 0.925 rs13199775 chr6:25828782 A/T cg16898833 chr6:26189333 HIST1H4D 0.75 6.28 0.33 1.04e-9 Intelligence (multi-trait analysis); CRC cis rs11030122 0.547 rs750525 chr11:3948894 G/A cg18678763 chr11:4115507 RRM1 -0.39 -6.61 -0.34 1.59e-10 Mean platelet volume;Platelet distribution width; CRC cis rs57221529 0.766 rs56278696 chr5:582669 A/G cg17948913 chr5:572064 NA 0.55 6.2 0.32 1.71e-9 Lung disease severity in cystic fibrosis; CRC cis rs4969178 0.965 rs16971107 chr17:76394042 C/T cg20026190 chr17:76395443 PGS1 0.38 5.87 0.31 1.07e-8 HDL cholesterol levels; CRC cis rs9467711 0.606 rs9379899 chr6:26603015 T/A cg12315302 chr6:26189340 HIST1H4D 0.81 6.23 0.32 1.45e-9 Autism spectrum disorder or schizophrenia; CRC cis rs875971 0.798 rs57739047 chr7:65972566 A/T cg00343986 chr7:65444356 GUSB 0.42 5.99 0.31 5.46e-9 Aortic root size; CRC cis rs870825 0.616 rs35818632 chr4:185649661 G/T cg07424746 chr4:185654737 MLF1IP -0.57 -5.78 -0.3 1.78e-8 Blood protein levels; CRC trans rs2727020 0.729 rs10839283 chr11:49490943 T/C cg15704280 chr7:45808275 SEPT13 0.8 12.11 0.56 3.57e-28 Coronary artery disease; CRC cis rs9303280 0.806 rs9303279 chr17:38073968 G/C cg11212589 chr17:38028394 ZPBP2 -0.39 -6.93 -0.36 2.22e-11 Self-reported allergy; CRC cis rs7811142 1.000 rs11763511 chr7:100081944 G/A cg00814883 chr7:100076585 TSC22D4 -0.74 -9.4 -0.46 9.54e-19 Platelet count; CRC cis rs7224737 1.000 rs7219220 chr17:40294280 T/C cg02228675 chr17:40259724 DHX58 -0.48 -6.78 -0.35 5.67e-11 Fibrinogen levels; CRC cis rs1552244 0.572 rs68013239 chr3:10165711 G/T cg18598329 chr3:10140678 FANCD2;C3orf24 -0.91 -10.81 -0.51 1.62e-23 Alzheimer's disease; CRC trans rs10506458 0.688 rs73127095 chr12:63418283 T/G cg03429785 chr15:59498649 MYO1E;LDHAL6B -1.07 -14.92 -0.64 8.16e-39 Hemostatic factors and hematological phenotypes; CRC cis rs2832191 0.755 rs2832192 chr21:30491173 G/T cg24692254 chr21:30365293 RNF160 -0.7 -11.85 -0.55 3.29e-27 Dental caries; CRC cis rs524281 0.861 rs11227415 chr11:65885459 C/T cg16950941 chr11:66035639 RAB1B 0.6 7.43 0.38 9.29e-13 Electroencephalogram traits; CRC cis rs7618915 0.547 rs10865973 chr3:52718154 A/T cg07507251 chr3:52567010 NT5DC2 0.46 6.6 0.34 1.68e-10 Bipolar disorder; CRC cis rs4604732 0.631 rs60311891 chr1:247623127 C/T cg02104434 chr1:247694406 LOC148824;OR2C3 0.6 8.57 0.43 4e-16 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CRC cis rs12681288 0.862 rs7814070 chr8:1020991 A/G cg15309053 chr8:964076 NA 0.41 7.29 0.37 2.37e-12 Schizophrenia; CRC cis rs2153535 0.541 rs7774752 chr6:8468978 C/T cg07606381 chr6:8435919 SLC35B3 0.68 10.9 0.51 8.26e-24 Motion sickness; CRC cis rs7666738 0.830 rs11938686 chr4:98964470 A/G cg17366294 chr4:99064904 C4orf37 0.43 7.24 0.37 3.23e-12 Colonoscopy-negative controls vs population controls; CRC cis rs1465370 0.682 rs6972781 chr7:130023179 A/G cg03229158 chr7:130009420 NA 0.43 6.2 0.32 1.73e-9 Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction);Waist circumference adjusted for BMI in active individuals;Waist circumference adjusted for body mass index; CRC cis rs13108904 0.901 rs12509700 chr4:1296321 A/G cg20092199 chr4:1342459 KIAA1530 0.42 7.71 0.39 1.52e-13 Obesity-related traits; CRC cis rs10512697 1.000 rs62335224 chr5:3568744 A/G cg19473799 chr5:3511975 NA -0.76 -5.81 -0.31 1.44e-8 Immune response to smallpox vaccine (IL-6); CRC cis rs7811142 0.775 rs1059129 chr7:99926522 A/G cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.82 10.78 0.51 2.1e-23 Platelet count; CRC cis rs3020333 0.703 rs862346 chr6:152016369 A/T cg22157087 chr6:152012887 ESR1 0.48 7.41 0.38 1.08e-12 Total body bone mineral density; CRC cis rs4474465 1.000 rs7950756 chr11:78157309 A/G cg27205649 chr11:78285834 NARS2 -0.45 -5.75 -0.3 2.04e-8 Alzheimer's disease (survival time); CRC cis rs798554 0.757 rs1183085 chr7:2875570 G/A cg13628971 chr7:2884303 GNA12 0.53 7.07 0.36 9.14e-12 Height; CRC cis rs17095355 1.000 rs9630101 chr10:111738451 T/C cg00817464 chr10:111662876 XPNPEP1 -0.61 -8.39 -0.42 1.43e-15 Biliary atresia; CRC trans rs2228479 0.850 rs17226428 chr16:89842884 T/A cg24644049 chr4:85504048 CDS1 0.92 7.68 0.39 1.79e-13 Skin colour saturation; CRC cis rs11025559 0.812 rs16906280 chr11:20472242 T/C cg19653624 chr11:20408972 PRMT3 -0.7 -8.34 -0.42 2e-15 Pursuit maintenance gain; CRC cis rs4713118 0.738 rs200465 chr6:27757654 T/A cg26587870 chr6:27730563 NA -0.47 -6.94 -0.36 2.08e-11 Parkinson's disease; CRC cis rs4077515 0.504 rs10870164 chr9:139315682 C/T cg14169450 chr9:139327907 INPP5E -0.35 -5.64 -0.3 3.6e-8 Ulcerative colitis;IgA nephropathy;Inflammatory bowel disease;Crohn's disease; CRC cis rs951366 0.668 rs823154 chr1:205762406 C/T cg24739457 chr1:205821442 NA 0.43 6.18 0.32 1.86e-9 Menarche (age at onset); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg04185037 chr6:159239164 EZR 0.41 6.05 0.32 4.02e-9 Liver disease severity in Alagille syndrome; CRC trans rs4308415 0.726 rs13122686 chr4:67810818 C/A cg19648955 chr2:177134095 MTX2 -0.41 -6.14 -0.32 2.4e-9 Educational attainment (years of education); CRC trans rs12458462 0.892 rs2242174 chr18:77458037 T/C cg09220050 chr20:48770642 TMEM189;TMEM189-UBE2V1 -0.46 -6.7 -0.35 8.79e-11 Monocyte count; CRC cis rs60871478 1.000 rs34260834 chr7:822958 A/G cg13844804 chr7:814759 HEATR2 0.61 8.01 0.4 1.98e-14 Cerebrospinal P-tau181p levels; CRC cis rs9322193 0.962 rs9688750 chr6:149978769 T/C cg00933542 chr6:150070202 PCMT1 0.28 5.67 0.3 3.15e-8 Lung cancer; CRC cis rs6752107 0.936 rs10187822 chr2:234206474 C/T cg07618928 chr2:234183455 ATG16L1;SCARNA5 0.59 9.48 0.46 5.36e-19 Crohn's disease;Inflammatory bowel disease; CRC cis rs6951245 0.872 rs113119264 chr7:1080564 G/A cg20603222 chr7:1096387 C7orf50;GPR146 -0.68 -7.91 -0.4 4e-14 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs8141529 0.778 rs5762795 chr22:29182500 C/A cg02153584 chr22:29168773 CCDC117 0.51 7.63 0.39 2.56e-13 Lymphocyte counts; CRC cis rs2635047 1.000 rs2684818 chr18:44712965 C/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.44 7.22 0.37 3.57e-12 Educational attainment; CRC cis rs7264396 0.790 rs2295355 chr20:34252654 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.61 -10.31 -0.49 8.99e-22 Total cholesterol levels; CRC cis rs2380220 0.935 rs7744491 chr6:95994980 T/G cg07718321 chr6:96025334 MANEA 0.52 6.11 0.32 2.82e-9 Behavioural disinhibition (generation interaction); CRC cis rs736408 0.609 rs13087772 chr3:52782274 T/G cg10802521 chr3:52805072 NEK4 -0.57 -8.73 -0.43 1.32e-16 Bipolar disorder; CRC cis rs4713118 0.662 rs9393881 chr6:28023751 C/G cg02683197 chr6:28174875 NA 0.71 9.02 0.45 1.64e-17 Parkinson's disease; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg07747515 chr11:61659326 FADS3 0.4 6.2 0.32 1.7e-9 Liver disease severity in Alagille syndrome; CRC cis rs66573146 0.656 rs56094305 chr4:6956086 C/T cg26116260 chr4:7069785 GRPEL1 -0.6 -5.81 -0.31 1.48e-8 Granulocyte percentage of myeloid white cells; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg07545714 chr3:122135128 WDR5B 0.45 6.33 0.33 8.17e-10 Response to antipsychotic treatment; CRC cis rs2249694 0.960 rs4335490 chr10:135402350 T/C cg16964102 chr10:135390573 NA 0.45 7.56 0.38 4e-13 Obesity-related traits; CRC cis rs1008375 1.000 rs7673500 chr4:17621383 C/T cg02297831 chr4:17616191 MED28 0.43 5.76 0.3 1.93e-8 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs7923609 0.967 rs4486511 chr10:65264266 C/T cg08743896 chr10:65200160 JMJD1C -0.42 -5.94 -0.31 7.27e-9 Educational attainment;Liver enzyme levels (alkaline phosphatase); CRC cis rs736408 0.609 rs13082208 chr3:52781539 T/G cg10802521 chr3:52805072 NEK4 -0.58 -8.83 -0.44 6.2e-17 Bipolar disorder; CRC cis rs1448094 0.935 rs4919775 chr12:86339985 T/C cg02569458 chr12:86230093 RASSF9 0.38 6.57 0.34 1.99e-10 Major depressive disorder; CRC cis rs875971 0.508 rs10950045 chr7:66066373 T/C cg18876405 chr7:65276391 NA -0.6 -10.65 -0.51 5.83e-23 Aortic root size; CRC cis rs2180341 0.961 rs7775493 chr6:127615000 C/A cg27446573 chr6:127587934 RNF146 0.99 14.76 0.63 3.48e-38 Breast cancer; CRC cis rs3749237 0.595 rs7637999 chr3:49535115 C/T cg03060546 chr3:49711283 APEH 0.69 11.99 0.55 1.02e-27 Resting heart rate; CRC cis rs3008870 1.000 rs12117131 chr1:67451922 C/T cg08660285 chr1:67390436 MIER1;WDR78 -1.03 -14.98 -0.64 4.69e-39 Lymphocyte percentage of white cells; CRC cis rs6912958 0.559 rs2985039 chr6:88041757 A/G cg04972856 chr6:88032051 C6orf162;GJB7 0.35 6.5 0.34 2.92e-10 Monocyte percentage of white cells; CRC cis rs1552244 1.000 rs35993975 chr3:10067794 A/G cg10729496 chr3:10149963 C3orf24 0.6 7.06 0.36 9.86e-12 Alzheimer's disease; CRC cis rs6866344 0.697 rs11739893 chr5:178127837 G/A cg03877680 chr5:178157825 ZNF354A 0.79 11.31 0.53 2.93e-25 Neutrophil percentage of white cells; CRC cis rs1150668 0.796 rs1124132 chr6:28380321 T/G cg25164649 chr6:28176230 NA 0.4 5.72 0.3 2.42e-8 Pubertal anthropometrics; CRC trans rs7619427 0.643 rs6791785 chr3:44093101 G/A cg09408571 chr1:101003634 GPR88 0.55 6.09 0.32 3.13e-9 Schizophrenia; CRC cis rs7586879 0.681 rs6723803 chr2:25120713 G/C cg04586622 chr2:25135609 ADCY3 -0.55 -10.2 -0.49 2.06e-21 Body mass index; CRC cis rs3849570 0.695 rs1851930 chr3:81895318 T/G cg07356753 chr3:81810745 GBE1 -0.56 -7.48 -0.38 6.72e-13 Waist circumference;Body mass index; CRC cis rs873946 0.590 rs12259699 chr10:134549692 A/G cg18305652 chr10:134549665 INPP5A 0.53 7.75 0.39 1.13e-13 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CRC cis rs1552244 0.872 rs7646073 chr3:10097405 G/A cg00166722 chr3:10149974 C3orf24 0.67 9.23 0.45 3.37e-18 Alzheimer's disease; CRC cis rs113835537 0.935 rs75863187 chr11:66443461 G/A cg22134325 chr11:66188745 NPAS4 0.4 6.66 0.34 1.13e-10 Airway imaging phenotypes; CRC cis rs7172809 0.643 rs4243046 chr15:77834746 T/C cg10437265 chr15:77819839 NA -0.39 -6.56 -0.34 2.08e-10 Glucose homeostasis traits; CRC cis rs4285028 0.747 rs9817818 chr3:121466826 C/A cg20356878 chr3:121714668 ILDR1 -0.42 -6.01 -0.31 5.02e-9 Multiple sclerosis; CRC cis rs939584 1.000 rs7567368 chr2:645082 T/C cg03610516 chr2:642275 NA 0.42 5.88 0.31 9.94e-9 Body mass index; CRC cis rs17234274 0.622 rs1586075 chr11:23237399 A/G cg05245346 chr11:23248277 NA 0.34 5.63 0.3 3.79e-8 Cancer; CRC cis rs2115630 0.691 rs8040066 chr15:85176465 G/C cg12501888 chr15:85177176 SCAND2 -0.48 -8.2 -0.41 5.43e-15 P wave terminal force; CRC cis rs1997103 0.871 rs1997101 chr7:55399652 A/T cg17469321 chr7:55412551 NA 0.73 11.31 0.53 2.75e-25 QRS interval (sulfonylurea treatment interaction); CRC cis rs943466 0.614 rs4713677 chr6:33731225 C/G cg11713064 chr6:33730089 NA -0.24 -5.89 -0.31 9.3e-9 Body mass index (joint analysis main effects and physical activity interaction);Body mass index; CRC cis rs282587 0.569 rs419334 chr13:113415346 G/A cg04656015 chr13:113407548 ATP11A 0.59 7.56 0.38 3.96e-13 Glycated hemoglobin levels; CRC cis rs9611565 0.512 rs5758465 chr22:42175314 T/C cg06634786 chr22:41940651 POLR3H 0.67 7.46 0.38 7.85e-13 Vitiligo; CRC cis rs4862750 0.872 rs1991254 chr4:187875375 T/G cg03647317 chr4:187891568 NA -0.55 -10.09 -0.49 4.95e-21 Lobe attachment (rater-scored or self-reported); CRC cis rs7246967 0.673 rs4933036 chr19:22963069 C/A cg08271804 chr19:22816896 ZNF492 0.38 5.85 0.31 1.2e-8 Bronchopulmonary dysplasia; CRC cis rs6499255 1.000 rs55863174 chr16:69819996 G/C cg00738113 chr16:70207722 CLEC18C -0.43 -6.16 -0.32 2.07e-9 IgE levels; CRC cis rs9522267 0.511 rs4773397 chr13:112245044 T/C cg10483660 chr13:112241077 NA -0.47 -8.9 -0.44 3.78e-17 Hepatitis; CRC cis rs877282 0.898 rs11253343 chr10:765117 C/T cg06581033 chr10:766294 NA -0.53 -5.88 -0.31 1.01e-8 Uric acid levels; CRC cis rs651907 0.535 rs34161138 chr3:101510388 T/C cg11279151 chr3:101281821 RG9MTD1 -0.53 -7.08 -0.36 8.95e-12 Colorectal cancer; CRC cis rs2479724 0.846 rs2254474 chr6:41843044 T/G cg17623882 chr6:41773611 USP49 -0.52 -8.67 -0.43 2.01e-16 Menarche (age at onset); CRC cis rs9341808 0.718 rs9343971 chr6:80882056 C/T cg08355045 chr6:80787529 NA 0.43 7.05 0.36 1.04e-11 Sitting height ratio; CRC cis rs6968419 0.649 rs58624059 chr7:115868798 T/C cg02561103 chr7:115862891 TES -0.43 -6.43 -0.33 4.62e-10 Intraocular pressure; CRC cis rs4853012 0.941 rs78128123 chr2:74347525 C/T cg05890377 chr2:74357713 NA 0.66 9.87 0.48 2.7e-20 Gestational age at birth (maternal effect); CRC cis rs13217239 0.646 rs10946891 chr6:26973215 T/C cg05192639 chr6:26864778 GUSBL1 0.31 6.01 0.31 5.05e-9 Schizophrenia; CRC cis rs7589728 0.858 rs1914734 chr2:88529509 T/C cg07952391 chr2:88470173 THNSL2 0.52 6.04 0.32 4.23e-9 Plasma clusterin levels; CRC cis rs9462027 0.628 rs10947532 chr6:34780315 G/T cg07306190 chr6:34760872 UHRF1BP1 -0.34 -5.95 -0.31 6.95e-9 Systemic lupus erythematosus; CRC cis rs311392 0.902 rs419813 chr8:55092385 A/T cg06042504 chr8:55087323 NA -0.44 -6.82 -0.35 4.41e-11 Pelvic organ prolapse (moderate/severe); CRC cis rs910316 0.712 rs175074 chr14:75504454 G/A cg08847533 chr14:75593920 NEK9 -0.82 -14.48 -0.62 4.14e-37 Height; CRC trans rs9929218 0.954 rs12928043 chr16:68828885 G/A cg04657470 chr2:198365150 HSPE1;HSPD1 -0.77 -11.07 -0.52 2.04e-24 Colorectal cancer; CRC cis rs9329289 0.510 rs28579610 chr10:2546080 C/A cg15501526 chr10:2543763 NA 0.52 9.72 0.47 8.7e-20 Age-related hearing impairment; CRC cis rs1865760 0.827 rs9295680 chr6:25944103 T/C cg17691542 chr6:26056736 HIST1H1C 0.52 7.65 0.39 2.24e-13 Height; CRC cis rs896854 0.654 rs13248607 chr8:95986637 T/G cg09323728 chr8:95962352 TP53INP1 -0.44 -7.17 -0.37 5.08e-12 Type 2 diabetes; CRC cis rs7618915 0.501 rs34739010 chr3:52766122 A/G cg08222913 chr3:52553049 STAB1 -0.33 -6.12 -0.32 2.72e-9 Bipolar disorder; CRC cis rs9649213 0.593 rs6961438 chr7:98005849 T/C cg08684580 chr7:98029266 BAIAP2L1 -0.32 -5.69 -0.3 2.88e-8 Prostate cancer (SNP x SNP interaction); CRC cis rs9361491 0.657 rs2321773 chr6:79476243 G/A cg09184832 chr6:79620586 NA -0.33 -5.69 -0.3 2.76e-8 Intelligence (multi-trait analysis); CRC cis rs7412746 0.658 rs2275235 chr1:150730279 A/G cg17724175 chr1:150552817 MCL1 0.49 7.3 0.37 2.19e-12 Melanoma; CRC cis rs67311347 1.000 rs73080138 chr3:40516417 A/G cg24209194 chr3:40518798 ZNF619 0.41 6.14 0.32 2.36e-9 Renal cell carcinoma; CRC cis rs12908161 0.515 rs12907646 chr15:85403496 G/A cg11189052 chr15:85197271 WDR73 0.52 6.77 0.35 5.8200000000000003e-11 Schizophrenia; CRC trans rs17685 0.712 rs28456330 chr7:75810542 A/G cg19862616 chr7:65841803 NCRNA00174 0.96 16.82 0.68 3.12e-46 Coffee consumption;Coffee consumption (cups per day); CRC cis rs78545713 0.649 rs113407109 chr6:26224403 T/G cg01420254 chr6:26195488 NA 0.73 6.04 0.32 4.13e-9 Iron status biomarkers (total iron binding capacity); CRC cis rs1552244 1.000 rs17032295 chr3:10086680 C/T cg00166722 chr3:10149974 C3orf24 0.68 9.46 0.46 6.2e-19 Alzheimer's disease; CRC trans rs10269006 0.613 rs12704744 chr7:94373916 A/T cg05903386 chr2:217555456 IGFBP5 -0.39 -6.47 -0.34 3.64e-10 Breast cancer; CRC cis rs853679 0.569 rs9348798 chr6:28143011 G/A cg12172441 chr6:28176163 NA 0.63 7.43 0.38 9.41e-13 Depression; CRC cis rs10504229 1.000 rs74546828 chr8:58171678 A/G cg01721255 chr8:58191610 C8orf71 0.49 6.17 0.32 2e-9 Developmental language disorder (linguistic errors); CRC cis rs2014572 0.967 rs10413037 chr19:57771883 A/G cg12963866 chr19:57752005 ZNF805 -0.44 -6.65 -0.34 1.2e-10 Hyperactive-impulsive symptoms; CRC cis rs853679 0.517 rs9393885 chr6:28050009 A/T cg23161317 chr6:28129485 ZNF389 0.5 6.21 0.32 1.57e-9 Depression; CRC cis rs2404602 0.684 rs2454451 chr15:76861461 G/T cg23625390 chr15:77176239 SCAPER 0.8 13.28 0.59 1.59e-32 Blood metabolite levels; CRC cis rs6459804 1.000 rs6459805 chr7:157510294 T/C cg05731713 chr7:157510257 PTPRN2 0.47 7.92 0.4 3.78e-14 Bipolar disorder and schizophrenia; CRC cis rs243505 0.898 rs243544 chr7:148402710 T/A cg09806900 chr7:148480153 CUL1 -0.42 -5.84 -0.31 1.28e-8 Inflammatory bowel disease;Crohn's disease; CRC cis rs16882447 0.514 rs27677 chr5:53484164 C/G cg06461071 chr5:53490839 ARL15 -0.35 -5.67 -0.3 3.12e-8 Systolic blood pressure (dietary potassium intake interaction); CRC cis rs67311347 0.956 rs12633446 chr3:40505661 G/A cg09455208 chr3:40491958 NA -0.4 -8.06 -0.41 1.47e-14 Renal cell carcinoma; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg09230774 chr11:67169262 PPP1CA 0.41 6.37 0.33 6.51e-10 Intelligence (multi-trait analysis); CRC cis rs2576037 0.562 rs612519 chr18:44379490 G/A cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.53 -8.09 -0.41 1.15e-14 Personality dimensions; CRC cis rs7937682 0.587 rs571594 chr11:111359334 A/G cg09085632 chr11:111637200 PPP2R1B 0.6 8.68 0.43 1.87e-16 Primary sclerosing cholangitis; CRC trans rs9354352 0.935 rs9345749 chr6:66699892 G/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.56 -8.04 -0.41 1.67e-14 Initial pursuit acceleration in psychotic disorders; CRC cis rs2153535 0.580 rs965706 chr6:8464708 G/A cg21535247 chr6:8435926 SLC35B3 0.5 7.53 0.38 4.89e-13 Motion sickness; CRC cis rs2298450 0.717 rs2835324 chr21:37610551 C/G cg02919814 chr21:37666008 DOPEY2 0.46 6.16 0.32 2.11e-9 Schizophrenia; CRC cis rs11690935 0.959 rs13419987 chr2:172623914 T/C cg13550731 chr2:172543902 DYNC1I2 -1.09 -17.95 -0.7 1.01e-50 Schizophrenia; CRC cis rs637571 0.780 rs653914 chr11:65676516 A/G cg26695010 chr11:65641043 EFEMP2 -0.45 -6.53 -0.34 2.53e-10 Eosinophil percentage of white cells; CRC cis rs6951245 1.000 rs76388414 chr7:1100694 G/A cg22907277 chr7:1156413 C7orf50 0.73 7.68 0.39 1.78e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs1552244 0.938 rs66915020 chr3:10110174 A/G cg13047869 chr3:10149882 C3orf24 0.54 7.5 0.38 6.09e-13 Alzheimer's disease; CRC cis rs875971 0.929 rs10950041 chr7:65973875 T/C cg11764359 chr7:65958608 NA 0.63 10.25 0.49 1.39e-21 Aortic root size; CRC cis rs1862618 0.573 rs2034245 chr5:56243685 T/C cg03609598 chr5:56110824 MAP3K1 0.74 8.83 0.44 6.52e-17 Initial pursuit acceleration; CRC cis rs9326248 0.501 rs4938351 chr11:117022352 A/C cg10130564 chr11:117069849 TAGLN 0.31 5.93 0.31 7.66e-9 Blood protein levels; CRC cis rs77861329 1.000 rs9868101 chr3:52138377 T/C cg08692210 chr3:52188851 WDR51A 0.86 7.96 0.4 2.79e-14 Macrophage inflammatory protein 1b levels; CRC cis rs2274273 0.624 rs10141396 chr14:55816925 A/C cg10130446 chr14:55658398 DLGAP5 -0.41 -5.82 -0.31 1.38e-8 Protein biomarker; CRC cis rs3793683 0.556 rs2803989 chr10:134560596 C/T cg27286337 chr10:134555280 INPP5A 0.62 8.34 0.42 2.1e-15 Migraine; CRC cis rs600231 0.708 rs3132767 chr11:65234860 C/T cg17120908 chr11:65337727 SSSCA1 -0.54 -8.02 -0.4 1.86e-14 Bone mineral density; CRC cis rs6740322 0.748 rs6755601 chr2:43483044 C/T cg06169590 chr2:43455088 ZFP36L2;LOC100129726 -0.7 -8.98 -0.44 2.07e-17 Coronary artery disease; CRC cis rs62229266 0.609 rs12482541 chr21:37419743 A/G cg12218747 chr21:37451666 NA -0.37 -6.24 -0.33 1.31e-9 Mitral valve prolapse; CRC cis rs7208859 0.673 rs11080138 chr17:29224542 A/G cg01831904 chr17:28903510 LRRC37B2 -0.56 -5.83 -0.31 1.35e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs9341808 0.754 rs3793000 chr6:80995137 G/A cg08355045 chr6:80787529 NA 0.35 5.7 0.3 2.69e-8 Sitting height ratio; CRC cis rs7191439 0.657 rs3826076 chr16:88780518 C/T cg27087555 chr16:88793112 FAM38A 1.16 11.81 0.55 4.52e-27 Plateletcrit; CRC cis rs11758351 0.660 rs11753655 chr6:26220109 C/T cg08260959 chr6:26240920 HIST1H4F -0.35 -5.66 -0.3 3.38e-8 Gout;Renal underexcretion gout; CRC trans rs877282 0.583 rs11253429 chr10:823234 A/C cg22713356 chr15:30763199 NA 0.78 8.63 0.43 2.75e-16 Uric acid levels; CRC cis rs2882667 0.598 rs288020 chr5:138224298 A/G cg09476006 chr5:138032270 NA 0.57 10.13 0.49 3.47e-21 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs142518269 1 rs142518269 chr2:24087095 G/A cg08917208 chr2:24149416 ATAD2B 1.04 10.12 0.49 3.79e-21 Mean corpuscular hemoglobin; CRC cis rs7208859 0.673 rs11651802 chr17:29159660 T/C cg01831904 chr17:28903510 LRRC37B2 -0.55 -5.78 -0.3 1.7e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs4713118 0.586 rs6905522 chr6:28086479 A/C cg12963246 chr6:28129442 ZNF389 0.5 5.8 0.3 1.53e-8 Parkinson's disease; CRC trans rs7726839 0.540 rs12520279 chr5:657291 T/C cg11887960 chr12:57824829 NA 0.64 7.2 0.37 4.1e-12 Obesity-related traits; CRC cis rs7584330 0.740 rs13404177 chr2:238441412 T/C cg14458575 chr2:238380390 NA 0.47 8.37 0.42 1.64e-15 Prostate cancer; CRC trans rs9329221 0.678 rs560638 chr8:9882767 A/G cg06636001 chr8:8085503 FLJ10661 -0.55 -8.37 -0.42 1.65e-15 Neuroticism; CRC cis rs11785400 0.793 rs750530 chr8:143744931 G/A cg24634471 chr8:143751801 JRK 0.47 6.39 0.33 5.75e-10 Schizophrenia; CRC cis rs78707713 0.560 rs35060419 chr10:71229539 A/G cg12610070 chr10:71211762 TSPAN15 -0.43 -7.45 -0.38 8.5e-13 Venous thromboembolism; CRC cis rs9733 0.791 rs11204693 chr1:150647987 C/T cg18016565 chr1:150552671 MCL1 -0.41 -6.1 -0.32 2.97e-9 Tonsillectomy; CRC trans rs7618501 1.000 rs7618519 chr3:49772708 A/T cg21665057 chr3:196295764 WDR53;FBXO45 -0.86 -15.78 -0.66 3.79e-42 Intelligence (multi-trait analysis); CRC cis rs1555322 0.530 rs2297789 chr20:33867248 A/T cg03689076 chr20:33865952 NA 0.49 6.94 0.36 2.06e-11 Attention deficit hyperactivity disorder; CRC cis rs6662572 0.737 rs9429093 chr1:46555252 T/C cg08644498 chr1:46502608 NA 0.43 7.13 0.37 6.51e-12 Blood protein levels; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg08079518 chr17:73775869 H3F3B 0.39 6.34 0.33 7.46e-10 Liver disease severity in Alagille syndrome; CRC trans rs7615952 0.866 rs11922276 chr3:125631326 G/T cg07211511 chr3:129823064 LOC729375 -1.1 -17.5 -0.69 5.96e-49 Blood pressure (smoking interaction); CRC cis rs6142102 0.923 rs6059635 chr20:32613493 A/T cg08999081 chr20:33150536 PIGU 0.4 5.92 0.31 8.15e-9 Skin pigmentation; CRC cis rs4563143 0.663 rs10417671 chr19:29235335 T/C cg03161606 chr19:29218774 NA 0.59 7.88 0.4 4.97e-14 Methadone dose in opioid dependence; CRC cis rs7605827 0.930 rs4668921 chr2:15672071 T/C cg19274914 chr2:15703543 NA 0.39 5.87 0.31 1.07e-8 Educational attainment (years of education); CRC cis rs9847710 0.670 rs36051354 chr3:52986012 T/C cg18099408 chr3:52552593 STAB1 0.39 5.7 0.3 2.73e-8 Ulcerative colitis; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg19187145 chr15:49338251 SECISBP2L 0.42 6.22 0.32 1.5e-9 Intelligence (multi-trait analysis); CRC cis rs823143 0.570 rs1361754 chr1:205801872 C/T cg17178900 chr1:205818956 PM20D1 -0.55 -8.47 -0.42 8.04e-16 Monocyte percentage of white cells; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg22727761 chr1:24286270 PNRC2 0.41 6.79 0.35 5.28e-11 Liver disease severity in Alagille syndrome; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg16308101 chr1:67895914 SERBP1 0.57 9.7 0.47 9.56e-20 Liver disease severity in Alagille syndrome; CRC cis rs6541297 0.702 rs4846904 chr1:230279410 G/A cg20703242 chr1:230279135 GALNT2 0.51 7.93 0.4 3.39e-14 Coronary artery disease; CRC cis rs597539 0.652 rs516425 chr11:68715675 G/A cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.82 13.76 0.6 2.35e-34 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs7020830 0.858 rs1492714 chr9:37141259 T/C cg14294708 chr9:37120828 ZCCHC7 1.22 28.81 0.85 5.44e-92 Schizophrenia; CRC cis rs853679 0.517 rs34716816 chr6:28046169 C/A cg15786705 chr6:28176104 NA 0.73 9.31 0.46 1.85e-18 Depression; CRC trans rs7267979 0.816 rs405822 chr20:25501314 A/G cg17903999 chr18:56338584 MALT1 -0.4 -6.54 -0.34 2.33e-10 Liver enzyme levels (alkaline phosphatase); CRC cis rs12541635 0.934 rs7008840 chr8:107016404 T/C cg10147462 chr8:107024639 NA 0.44 7.15 0.37 5.49e-12 Age of smoking initiation; CRC cis rs172166 0.516 rs1225618 chr6:28129713 A/C cg06470822 chr6:28175283 NA 0.66 10.12 0.49 3.83e-21 Cardiac Troponin-T levels; CRC cis rs9457247 1.000 rs2769352 chr6:167378619 A/G cg23791538 chr6:167370224 RNASET2 0.38 5.87 0.31 1.04e-8 Crohn's disease; CRC cis rs780096 0.546 rs715326 chr2:27725761 A/G cg24768116 chr2:27665128 KRTCAP3 0.34 7.66 0.39 2.15e-13 Total body bone mineral density; CRC cis rs9487051 0.676 rs4383852 chr6:109594475 G/A cg01475377 chr6:109611718 NA -0.39 -6.79 -0.35 5.39e-11 Reticulocyte fraction of red cells; CRC cis rs6479527 0.933 rs10993058 chr9:96873151 C/A cg14459158 chr9:96720562 NA 0.43 7.43 0.38 9.65e-13 Esophageal adenocarcinoma; CRC trans rs2710642 0.962 rs6545972 chr2:63084682 G/A cg05376469 chr2:102649931 NA -0.37 -6.11 -0.32 2.81e-9 LDL cholesterol levels;LDL cholesterol; CRC cis rs8070740 0.898 rs4493114 chr17:5324207 G/A cg25236894 chr17:5323110 RPAIN;NUP88 0.48 7.46 0.38 7.92e-13 Menopause (age at onset); CRC cis rs9467773 0.967 rs9358954 chr6:26531178 A/G cg09904177 chr6:26538194 HMGN4 0.86 14.9 0.63 9.92e-39 Intelligence (multi-trait analysis); CRC cis rs13118159 0.771 rs13117476 chr4:1334721 A/G cg19318889 chr4:1322082 MAEA 0.5 7.45 0.38 8.26e-13 Longevity; CRC cis rs7616330 0.790 rs73118209 chr3:71040857 A/C cg01511742 chr3:71112437 FOXP1 -0.56 -6.56 -0.34 2.12e-10 QT interval; CRC cis rs6952808 0.862 rs4721167 chr7:1933224 C/T cg20295408 chr7:1910781 MAD1L1 -0.43 -6.15 -0.32 2.29e-9 Bipolar disorder and schizophrenia; CRC cis rs1008375 0.933 rs4698637 chr4:17632843 A/T cg16339924 chr4:17578868 LAP3 0.6 7.68 0.39 1.79e-13 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs554111 0.613 rs10753510 chr1:21412248 G/A cg02927042 chr1:21476669 EIF4G3 0.38 5.71 0.3 2.5e-8 Facial morphology (factor 17, height of vermillion upper lip); CRC cis rs10028773 0.506 rs12374346 chr4:120281705 G/A cg24375607 chr4:120327624 NA 0.48 7.48 0.38 6.72e-13 Educational attainment; CRC cis rs10504229 0.906 rs7006539 chr8:58178799 A/T cg02290350 chr8:58132656 NA -0.43 -5.99 -0.31 5.63e-9 Developmental language disorder (linguistic errors); CRC cis rs3015497 0.789 rs3015500 chr14:51108877 C/T cg09863266 chr14:51125203 SAV1 -0.31 -5.77 -0.3 1.81e-8 Mean platelet volume; CRC trans rs6703335 0.870 rs10803142 chr1:243598234 A/G cg24106215 chr1:202927166 ADIPOR1 0.43 6.0 0.31 5.3300000000000004e-09 Schizophrenia;Schizophrenia, schizoaffective disorder or bipolar disorder; CRC cis rs896854 0.608 rs7004862 chr8:95876963 T/G cg13393036 chr8:95962371 TP53INP1 -0.45 -7.38 -0.38 1.27e-12 Type 2 diabetes; CRC cis rs73206853 0.841 rs74728497 chr12:111020179 T/C cg12870014 chr12:110450643 ANKRD13A 0.81 8.35 0.42 1.88e-15 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC cis rs763121 0.815 rs9306328 chr22:39028913 C/T cg06022373 chr22:39101656 GTPBP1 0.71 11.47 0.53 7.61e-26 Menopause (age at onset); CRC cis rs4926298 0.926 rs8111617 chr19:13191461 C/T cg23899408 chr19:12877188 HOOK2 -0.47 -6.52 -0.34 2.66e-10 Bipolar disorder; CRC cis rs7527798 0.592 rs960086 chr1:207827069 A/G cg21110645 chr1:207815933 NA -0.39 -6.18 -0.32 1.9e-9 Erythrocyte sedimentation rate; CRC cis rs8072100 0.811 rs1912483 chr17:45443494 A/G cg08085267 chr17:45401833 C17orf57 -0.68 -11.74 -0.54 8.34e-27 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs9527 0.545 rs12247514 chr10:104958066 C/A cg15744005 chr10:104629667 AS3MT -0.29 -5.76 -0.3 1.97e-8 Arsenic metabolism; CRC cis rs9611565 0.921 rs761366 chr22:41744022 C/G cg03806693 chr22:41940476 POLR3H -0.9 -11.71 -0.54 1.01e-26 Vitiligo; CRC cis rs950169 0.580 rs11634320 chr15:85172183 A/C cg17507749 chr15:85114479 UBE2QP1 -0.58 -8.3 -0.42 2.69e-15 Schizophrenia; CRC cis rs77972916 0.561 rs72788900 chr2:43559087 T/C cg06169590 chr2:43455088 ZFP36L2;LOC100129726 -0.63 -5.93 -0.31 7.64e-9 Granulocyte percentage of myeloid white cells; CRC cis rs2066819 1.000 rs57137641 chr12:56741228 G/A cg26714650 chr12:56694279 CS -1.41 -11.34 -0.53 2.29e-25 Psoriasis vulgaris; CRC cis rs972578 1.000 rs2092214 chr22:43363923 G/A cg01576275 chr22:43409880 NA -0.45 -7.27 -0.37 2.62e-12 Mean platelet volume; CRC cis rs780096 0.565 rs10169261 chr2:27727314 C/T cg02592271 chr2:27665507 KRTCAP3 -0.25 -5.76 -0.3 1.93e-8 Total body bone mineral density; CRC cis rs798554 0.704 rs798512 chr7:2782592 C/G cg17321639 chr7:2759063 NA -0.37 -5.65 -0.3 3.55e-8 Height; CRC trans rs2303319 0.504 rs56026147 chr2:162614089 T/C cg14875682 chr5:52083620 ITGA1;PELO -0.73 -6.16 -0.32 2.11e-9 Cognitive function; CRC cis rs1165668 0.755 rs2583283 chr12:104313643 G/A cg21863207 chr12:104234989 NT5DC3 0.48 7.15 0.37 5.76e-12 Coronary heart disease (SNP X SNP interaction); CRC cis rs8031584 0.679 rs34017474 chr15:31230611 T/C cg08109568 chr15:31115862 NA -0.43 -7.34 -0.38 1.64e-12 Huntington's disease progression; CRC cis rs6964587 0.967 rs10953063 chr7:91576958 A/G cg17063962 chr7:91808500 NA -0.79 -13.8 -0.61 1.73e-34 Breast cancer; CRC trans rs7647973 0.626 rs9830730 chr3:49675875 G/C cg21659725 chr3:3221576 CRBN -0.67 -7.42 -0.38 1e-12 Menarche (age at onset); CRC cis rs9858542 0.953 rs6779524 chr3:49450449 C/T cg00383909 chr3:49044727 WDR6 0.43 5.65 0.3 3.49e-8 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs1185460 0.967 rs2509121 chr11:118928253 C/T cg23280166 chr11:118938394 VPS11 0.4 5.88 0.31 1.01e-8 Coronary artery disease; CRC cis rs992157 0.710 rs56364928 chr2:219059058 G/A cg00012203 chr2:219082015 ARPC2 0.61 9.94 0.48 1.57e-20 Colorectal cancer; CRC cis rs7726839 0.540 rs72703078 chr5:594987 A/C cg09021430 chr5:549028 NA -0.72 -8.29 -0.42 2.99e-15 Obesity-related traits; CRC cis rs10911232 0.507 rs61081633 chr1:182995608 A/G ch.1.3577855R chr1:183094577 LAMC1 0.87 15.17 0.64 8.94e-40 Hypertriglyceridemia; CRC cis rs4285028 0.848 rs77630152 chr3:121681194 C/T cg20356878 chr3:121714668 ILDR1 -0.47 -6.74 -0.35 7.19e-11 Multiple sclerosis; CRC cis rs2354432 0.607 rs12402309 chr1:146721983 T/A cg25205988 chr1:146714368 CHD1L -1.17 -10.08 -0.49 5.18e-21 Mitochondrial DNA levels; CRC cis rs798554 0.797 rs798488 chr7:2802522 T/C cg13628971 chr7:2884303 GNA12 0.54 7.23 0.37 3.43e-12 Height; CRC cis rs904251 0.600 rs1874736 chr6:37447994 C/G cg25019722 chr6:37503610 NA -0.38 -6.59 -0.34 1.73e-10 Cognitive performance; CRC cis rs6502050 0.835 rs4789754 chr17:80091941 C/T cg11859384 chr17:80120422 CCDC57 -0.38 -5.9 -0.31 8.89e-9 Life satisfaction; CRC cis rs860295 0.702 rs4971095 chr1:155606224 G/A cg02153340 chr1:155202674 NA 0.53 6.92 0.36 2.43e-11 Body mass index; CRC cis rs17767392 1.000 rs61991248 chr14:71860529 C/A cg13720639 chr14:72061746 SIPA1L1 -0.54 -6.89 -0.35 2.93e-11 Mitral valve prolapse; CRC cis rs1005277 0.579 rs2505241 chr10:38442421 T/C cg00409905 chr10:38381863 ZNF37A -0.67 -11.12 -0.52 1.3e-24 Extrinsic epigenetic age acceleration; CRC cis rs9487051 0.837 rs6568561 chr6:109592909 A/G cg12927641 chr6:109611667 NA -0.37 -6.72 -0.35 8.16e-11 Reticulocyte fraction of red cells; CRC trans rs4650994 1.000 rs10913568 chr1:178513411 C/T cg05059571 chr16:84539110 KIAA1609 -0.48 -7.25 -0.37 2.91e-12 HDL cholesterol levels;HDL cholesterol; CRC cis rs2239547 0.618 rs3733047 chr3:52871929 A/G cg15147215 chr3:52552868 STAB1 0.45 6.29 0.33 9.84e-10 Schizophrenia; CRC cis rs898097 0.691 rs7222745 chr17:80907253 C/T cg19046167 chr17:80928561 B3GNTL1 -0.45 -7.86 -0.4 5.48e-14 Breast cancer; CRC cis rs4974559 0.739 rs28411197 chr4:1279781 C/T cg02980000 chr4:1222292 CTBP1 0.75 8.33 0.42 2.17e-15 Systolic blood pressure; CRC cis rs1552244 0.882 rs34706481 chr3:10004123 G/A cg16606324 chr3:10149918 C3orf24 0.58 7.11 0.37 7.07e-12 Alzheimer's disease; CRC cis rs951366 0.789 rs823097 chr1:205681370 G/A cg11965913 chr1:205819406 PM20D1 0.82 12.79 0.58 1.11e-30 Menarche (age at onset); CRC cis rs9534288 0.699 rs2146886 chr13:46646711 C/T cg15192986 chr13:46630673 CPB2 -0.7 -9.37 -0.46 1.22e-18 Blood protein levels; CRC cis rs12681287 0.547 rs9297921 chr8:87542286 C/T cg27223183 chr8:87520930 FAM82B 0.5 6.72 0.35 7.91e-11 Caudate activity during reward; CRC cis rs477895 0.838 rs1058735 chr11:64000410 C/G cg05016508 chr11:63871570 FLRT1;MACROD1 0.53 6.64 0.34 1.3e-10 Mean platelet volume; CRC cis rs7917772 0.503 rs746552 chr10:104342501 A/G cg22532475 chr10:104410764 TRIM8 -0.36 -6.55 -0.34 2.28e-10 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC cis rs7552404 0.731 rs11588578 chr1:76400539 T/G cg22875332 chr1:76189707 ACADM 0.53 6.53 0.34 2.52e-10 Blood metabolite levels;Acylcarnitine levels; CRC cis rs798554 0.671 rs1182195 chr7:2868730 A/G cg17321639 chr7:2759063 NA -0.41 -6.1 -0.32 2.92e-9 Height; CRC cis rs62229266 0.682 rs11700546 chr21:37371139 A/C cg08632701 chr21:37451849 NA -0.37 -5.67 -0.3 3.16e-8 Mitral valve prolapse; CRC trans rs9291683 0.704 rs11726271 chr4:10098192 G/A cg26043149 chr18:55253948 FECH -0.52 -8.01 -0.4 2.03e-14 Bone mineral density; CRC cis rs9611565 0.659 rs9611603 chr22:41912750 A/G cg17554472 chr22:41940697 POLR3H -0.52 -5.62 -0.3 4.11e-8 Vitiligo; CRC cis rs9527 0.545 rs10883847 chr10:104958284 C/T cg15744005 chr10:104629667 AS3MT -0.29 -5.76 -0.3 1.92e-8 Arsenic metabolism; CRC cis rs35306767 0.903 rs11253494 chr10:937047 C/T cg26597838 chr10:835615 NA 0.93 11.02 0.52 3e-24 Eosinophil percentage of granulocytes; CRC cis rs7605827 0.930 rs2010881 chr2:15624646 T/A cg19274914 chr2:15703543 NA 0.39 6.05 0.32 3.96e-9 Educational attainment (years of education); CRC trans rs9813712 0.574 rs62281647 chr3:129961513 C/T cg23942268 chr17:6347992 FAM64A -0.41 -6.01 -0.31 5.03e-9 Response to amphetamines; CRC cis rs6952808 0.929 rs12532128 chr7:1925454 T/C cg14004847 chr7:1930337 MAD1L1 -0.43 -5.79 -0.3 1.64e-8 Bipolar disorder and schizophrenia; CRC cis rs3736485 0.932 rs28795073 chr15:51927562 C/T cg08986416 chr15:51914746 DMXL2 -0.46 -6.55 -0.34 2.21e-10 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs7811142 0.830 rs1063945 chr7:99930447 C/T cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.07 14.95 0.64 6.32e-39 Platelet count; CRC cis rs910316 0.839 rs35977276 chr14:75637359 A/C cg08847533 chr14:75593920 NEK9 -0.94 -16.76 -0.68 5.27e-46 Height; CRC cis rs12500482 1.000 rs12500482 chr4:2430235 A/G cg26605046 chr4:2439731 NA -0.4 -7.1 -0.36 7.6e-12 Cognitive function; CRC trans rs208520 0.802 rs208516 chr6:66946119 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.92 -11.93 -0.55 1.6e-27 Exhaled nitric oxide output; CRC cis rs995000 0.965 rs10889334 chr1:62957199 C/G cg19896129 chr1:63156450 NA 0.4 5.84 0.31 1.26e-8 Triglyceride levels; CRC cis rs2075371 0.796 rs1643040 chr7:134011703 G/C cg20476274 chr7:133979776 SLC35B4 0.66 10.67 0.51 5.25e-23 Mean platelet volume; CRC cis rs780096 0.526 rs3845687 chr2:27689899 T/C cg12648201 chr2:27665141 KRTCAP3 -0.31 -6.01 -0.31 4.81e-9 Total body bone mineral density; CRC cis rs6500395 0.963 rs4785528 chr16:48687908 A/C cg04672837 chr16:48644449 N4BP1 -0.44 -6.6 -0.34 1.65e-10 Response to tocilizumab in rheumatoid arthritis; CRC cis rs1862618 0.620 rs189695 chr5:56225769 T/C cg03609598 chr5:56110824 MAP3K1 -0.59 -7.88 -0.4 4.77e-14 Initial pursuit acceleration; CRC cis rs12477438 0.765 rs2278895 chr2:99613484 G/A cg26064155 chr2:99771622 LIPT1;TSGA10 -0.63 -8.55 -0.43 4.61e-16 Chronic sinus infection; CRC cis rs2066819 1.000 rs75754909 chr12:56726349 A/G cg26714650 chr12:56694279 CS -1.41 -11.5 -0.54 5.96e-26 Psoriasis vulgaris; CRC cis rs73206853 0.841 rs60013768 chr12:110576095 A/G cg12870014 chr12:110450643 ANKRD13A 0.79 8.0 0.4 2.21e-14 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC cis rs8130944 0.822 rs1515756 chr21:44114770 A/C cg23590273 chr21:44105265 PDE9A -0.37 -5.8 -0.3 1.56e-8 Perceived unattractiveness to mosquitoes; CRC cis rs9479482 0.935 rs563278 chr6:150364427 G/C cg25797454 chr6:150327115 RAET1K 0.37 6.37 0.33 6.45e-10 Alopecia areata; CRC cis rs11583043 0.831 rs6667818 chr1:101412313 A/T cg16556008 chr1:101360663 SLC30A7;EXTL2 0.57 7.83 0.4 6.85e-14 Ulcerative colitis;Inflammatory bowel disease; CRC cis rs17376456 0.825 rs10061377 chr5:93174513 T/C cg09848695 chr5:92956644 FAM172A;MIR2277 0.7 6.46 0.34 3.74e-10 Diabetic retinopathy; CRC cis rs7811142 1.000 rs2897358 chr7:100088640 C/G cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.74 10.0 0.48 9.92e-21 Platelet count; CRC cis rs1580019 0.547 rs56981934 chr7:32535202 C/G cg06627557 chr7:32535165 LSM5;AVL9 1.01 20.95 0.76 1.6e-62 Cognitive ability; CRC cis rs13064411 0.696 rs1386336 chr3:113144153 C/T cg18753928 chr3:113234510 CCDC52 -0.63 -8.67 -0.43 1.95e-16 Response to simvastatin treatment (PCSK9 protein level change); CRC cis rs1129187 0.719 rs3805953 chr6:42936900 C/T cg27588902 chr6:42928151 GNMT -0.43 -7.71 -0.39 1.51e-13 Alzheimer's disease in APOE e4+ carriers; CRC cis rs6748734 1.000 rs4675860 chr2:241840417 A/G cg04034577 chr2:241836375 C2orf54 -0.42 -8.63 -0.43 2.73e-16 Urinary metabolites; CRC cis rs863345 0.604 rs59427353 chr1:158500621 A/C cg12129480 chr1:158549410 OR10X1 -0.3 -6.27 -0.33 1.12e-9 Pneumococcal bacteremia; CRC cis rs9462027 0.540 rs4282407 chr6:34830162 A/T cg07306190 chr6:34760872 UHRF1BP1 -0.34 -6.04 -0.32 4.22e-9 Systemic lupus erythematosus; CRC cis rs4555082 0.957 rs2816627 chr14:105736109 A/G cg10792982 chr14:105748885 BRF1 0.35 6.2 0.32 1.71e-9 Mean platelet volume;Platelet distribution width; CRC cis rs1697139 1.000 rs1697139 chr5:66511535 A/G cg16691251 chr5:66510806 NA 0.6 11.91 0.55 1.94e-27 Breast cancer; CRC cis rs9486719 0.948 rs2472906 chr6:96875318 G/T cg06623918 chr6:96969491 KIAA0776 0.81 9.51 0.46 4.17e-19 Migraine;Coronary artery disease; CRC cis rs703842 1.000 rs703842 chr12:58162739 C/T cg00677455 chr12:58241039 CTDSP2 -0.68 -9.91 -0.48 2e-20 Multiple sclerosis; CRC cis rs10504229 1.000 rs59549824 chr8:58186205 A/C cg02725872 chr8:58115012 NA -0.39 -6.52 -0.34 2.64e-10 Developmental language disorder (linguistic errors); CRC cis rs7274811 0.625 rs293722 chr20:31927361 C/T cg03904042 chr20:32255491 NECAB3;C20orf134 -0.45 -6.43 -0.33 4.52e-10 Height; CRC cis rs599083 0.530 rs583545 chr11:68178635 T/C cg01657329 chr11:68192670 LRP5 0.49 7.03 0.36 1.18e-11 Bone mineral density (spine); CRC cis rs4561483 0.801 rs33637 chr16:11989875 A/T cg08843971 chr16:11963173 GSPT1 -0.62 -9.58 -0.47 2.43e-19 Testicular germ cell tumor; CRC cis rs6456156 0.586 rs9457266 chr6:167482555 T/C cg07741184 chr6:167504864 NA 0.38 6.65 0.34 1.21e-10 Primary biliary cholangitis; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg16974379 chr10:38146505 ZNF248 0.5 6.51 0.34 2.87e-10 Thyroid stimulating hormone; CRC cis rs780096 0.526 rs4582 chr2:27604279 A/G cg17158414 chr2:27665306 KRTCAP3 -0.28 -5.93 -0.31 7.82e-9 Total body bone mineral density; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg10039051 chr12:123756720 CDK2AP1 0.51 6.64 0.34 1.33e-10 Thyroid stimulating hormone; CRC cis rs7107770 0.663 rs7111751 chr11:125075288 A/T cg27629782 chr11:125073726 PKNOX2 -0.49 -7.15 -0.37 5.62e-12 Photic sneeze reflex; CRC trans rs7647973 0.593 rs7620848 chr3:49828021 G/C cg21659725 chr3:3221576 CRBN 0.63 7.06 0.36 1.01e-11 Menarche (age at onset); CRC cis rs11758351 0.660 rs16891455 chr6:26230485 G/A cg10723962 chr6:26240782 HIST1H4F -0.39 -6.26 -0.33 1.21e-9 Gout;Renal underexcretion gout; CRC cis rs2976388 0.590 rs3736011 chr8:143817789 G/A cg22687807 chr8:143858763 LYNX1 -0.46 -7.56 -0.38 4.09e-13 Urinary tract infection frequency; CRC cis rs9303280 0.901 rs1008723 chr17:38066267 G/T cg20243544 chr17:37824526 PNMT 0.44 6.77 0.35 5.85e-11 Self-reported allergy; CRC trans rs6951245 1.000 rs1881123 chr7:1084706 C/T cg13565492 chr6:43139072 SRF -0.71 -7.25 -0.37 2.95e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs17666538 0.539 rs1703925 chr8:608279 A/G cg13264159 chr8:625131 ERICH1 -0.77 -7.15 -0.37 5.63e-12 IgG glycosylation; CRC cis rs853679 0.546 rs200981 chr6:27833174 A/G cg19041857 chr6:27730383 NA -0.76 -7.48 -0.38 6.83e-13 Depression; CRC cis rs1448094 0.717 rs60713909 chr12:86294469 C/G cg18827107 chr12:86230957 RASSF9 -0.47 -7.55 -0.38 4.22e-13 Major depressive disorder; CRC cis rs789859 1.000 rs789860 chr3:194405630 A/T cg02072170 chr3:194406190 FAM43A 0.43 7.35 0.38 1.59e-12 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; CRC cis rs9747201 1.000 rs12943668 chr17:80109930 C/T cg14673194 chr17:80132900 CCDC57 0.49 6.35 0.33 7.1e-10 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs17384381 0.906 rs2300639 chr1:85823676 T/A cg16011679 chr1:85725395 C1orf52 0.66 6.72 0.35 7.79e-11 Lobe attachment (rater-scored or self-reported); CRC cis rs2882667 0.690 rs160405 chr5:138084076 A/G cg09476006 chr5:138032270 NA 0.56 9.64 0.47 1.58e-19 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs1005277 0.579 rs2474588 chr10:38420870 A/G cg25517755 chr10:38738941 LOC399744 -0.42 -6.06 -0.32 3.79e-9 Extrinsic epigenetic age acceleration; CRC cis rs274567 0.501 rs2631368 chr5:131705297 T/G cg24060327 chr5:131705240 SLC22A5 0.55 8.59 0.43 3.55e-16 Blood metabolite levels; CRC cis rs9527 0.590 rs10786738 chr10:104869451 C/T cg04362960 chr10:104952993 NT5C2 0.61 8.46 0.42 8.85e-16 Arsenic metabolism; CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg22627950 chr7:44622302 TMED4 -0.53 -6.45 -0.34 3.94e-10 Diisocyanate-induced asthma; CRC cis rs975722 0.646 rs43032 chr7:117107284 A/C cg09181792 chr7:117119393 CFTR 0.27 5.6 0.3 4.51e-8 Coronary artery disease; CRC cis rs155076 1.000 rs567166 chr13:21837519 T/C cg25811766 chr13:21894605 NA -0.59 -6.07 -0.32 3.57e-9 White matter hyperintensity burden; CRC cis rs7586879 0.789 rs11688754 chr2:25133885 C/T cg04586622 chr2:25135609 ADCY3 -0.58 -9.66 -0.47 1.35e-19 Body mass index; CRC cis rs356992 1.000 rs356992 chr2:60753593 C/G cg08426369 chr2:60753602 BCL11A 0.52 6.94 0.36 2.15e-11 Educational attainment (years of education); CRC cis rs7524258 0.900 rs6577425 chr1:7306338 G/T cg07173049 chr1:7289937 CAMTA1 0.51 8.26 0.41 3.49e-15 Tourette's syndrome or obsessive-compulsive disorder; CRC cis rs3087591 0.708 rs2854305 chr17:29647003 G/A cg24425628 chr17:29625626 OMG;NF1 0.71 13.15 0.59 4.98e-32 Hip circumference; CRC cis rs9814567 0.806 rs2293294 chr3:134322814 G/C cg06109529 chr3:134205091 CEP63;ANAPC13 0.69 10.19 0.49 2.21e-21 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs8062405 1.000 rs12444171 chr16:28845251 G/A cg08761264 chr16:28874980 SH2B1 -0.42 -5.64 -0.3 3.73e-8 Cognitive ability (multi-trait analysis);Cognitive ability; CRC cis rs995000 0.931 rs10789114 chr1:63034222 T/C cg19896129 chr1:63156450 NA 0.39 5.67 0.3 3.14e-8 Triglyceride levels; CRC cis rs2354432 0.660 rs10751415 chr1:146830785 T/A cg25205988 chr1:146714368 CHD1L 1.14 10.04 0.48 7.37e-21 Mitochondrial DNA levels; CRC cis rs514406 0.584 rs12095247 chr1:53193796 A/C cg24675658 chr1:53192096 ZYG11B 0.67 10.25 0.49 1.46e-21 Monocyte count; CRC cis rs7811142 1.000 rs11763414 chr7:100016844 C/G cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.99 13.56 0.6 1.37e-33 Platelet count; CRC cis rs9308731 0.644 rs1837368 chr2:111874508 T/C cg04571233 chr2:111982156 NA -0.34 -5.72 -0.3 2.42e-8 Chronic lymphocytic leukemia; CRC cis rs1552244 1.000 rs17032283 chr3:10081545 C/G cg08888203 chr3:10149979 C3orf24 0.7 9.56 0.47 2.85e-19 Alzheimer's disease; CRC cis rs7914558 1.000 rs11191541 chr10:104824199 A/G cg04362960 chr10:104952993 NT5C2 0.6 9.04 0.45 1.38e-17 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs798554 0.660 rs2527687 chr7:2838485 G/A cg04166393 chr7:2884313 GNA12 0.39 5.8 0.3 1.53e-8 Height; CRC cis rs7666738 0.830 rs6848404 chr4:98946750 A/G cg17366294 chr4:99064904 C4orf37 0.43 7.34 0.38 1.69e-12 Colonoscopy-negative controls vs population controls; CRC trans rs72862334 0.554 rs6723151 chr2:146592034 C/G cg22809798 chr19:15284853 NOTCH3 -0.42 -6.19 -0.32 1.79e-9 Coronary artery disease; CRC cis rs7726839 0.574 rs12517345 chr5:628294 G/A cg17948913 chr5:572064 NA 0.51 5.89 0.31 9.53e-9 Obesity-related traits; CRC cis rs1348850 0.526 rs4144278 chr2:178412378 C/T cg27490568 chr2:178487706 NA 0.67 7.88 0.4 4.86e-14 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs5750830 0.649 rs5750818 chr22:39820885 A/G cg25956985 chr22:39795188 MAP3K7IP1 -0.47 -6.87 -0.35 3.15e-11 Intelligence (multi-trait analysis); CRC cis rs7178572 0.568 rs1191196 chr15:77646504 C/T cg22256960 chr15:77711686 NA 0.62 8.6 0.43 3.24e-16 Type 2 diabetes; CRC cis rs2228479 0.702 rs17233253 chr16:89828437 A/G cg06558623 chr16:89946397 TCF25 1.13 10.45 0.5 2.85e-22 Skin colour saturation; CRC trans rs1814175 0.817 rs2866545 chr11:49630824 A/C cg15704280 chr7:45808275 SEPT13 -0.98 -18.83 -0.72 3.41e-54 Height; CRC cis rs7927771 0.931 rs12361256 chr11:47910823 A/C cg05585544 chr11:47624801 NA -0.55 -10.01 -0.48 9.16e-21 Subjective well-being; CRC cis rs17125944 0.615 rs7146179 chr14:53298853 A/G cg00686598 chr14:53173677 PSMC6 -0.65 -6.09 -0.32 3.14e-9 Alzheimer's disease (late onset); CRC cis rs12431939 1.000 rs66806841 chr14:51670524 G/C cg23942311 chr14:51606299 NA -0.53 -6.36 -0.33 6.89e-10 Cancer; CRC trans rs10983614 1.000 rs7867776 chr9:120072627 A/G cg21942256 chr3:156892528 NA 0.45 5.98 0.31 5.76e-9 Survival in pancreatic cancer; CRC cis rs9303542 0.625 rs7207109 chr17:46607817 C/T cg04904318 chr17:46607828 HOXB1 -0.54 -6.57 -0.34 1.94e-10 Ovarian cancer;Epithelial ovarian cancer; CRC cis rs6964587 0.869 rs406 chr7:91546526 C/A cg17063962 chr7:91808500 NA -0.75 -12.63 -0.57 4.47e-30 Breast cancer; CRC cis rs977987 0.806 rs2865530 chr16:75414376 G/T cg03315344 chr16:75512273 CHST6 0.53 8.85 0.44 5.63e-17 Dupuytren's disease; CRC cis rs7615952 0.576 rs6780025 chr3:125815624 A/C cg15145296 chr3:125709740 NA -0.58 -6.77 -0.35 6.05e-11 Blood pressure (smoking interaction); CRC cis rs644799 0.687 rs3748252 chr11:95519195 A/T cg25622487 chr11:95524042 FAM76B;CEP57 -0.79 -13.14 -0.59 5.56e-32 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC trans rs9929218 1.000 rs4783570 chr16:68806539 G/T cg04657470 chr2:198365150 HSPE1;HSPD1 -0.82 -11.54 -0.54 4.33e-26 Colorectal cancer; CRC cis rs4925325 0.956 rs1776263 chr20:60515820 A/G cg18761221 chr20:60518478 NA 0.66 10.63 0.51 6.8e-23 Obesity-related traits; CRC cis rs9911578 0.967 rs2611781 chr17:56703124 C/G cg05425664 chr17:57184151 TRIM37 -0.49 -7.63 -0.39 2.48e-13 Intelligence (multi-trait analysis); CRC cis rs28655083 0.956 rs7184167 chr16:77069451 T/A cg01753188 chr16:77233325 SYCE1L;MON1B -0.6 -8.68 -0.43 1.91e-16 Lobe attachment (rater-scored or self-reported); CRC cis rs1552244 1.000 rs113522867 chr3:10154503 T/C cg18598329 chr3:10140678 FANCD2;C3orf24 -0.89 -11.73 -0.54 8.45e-27 Alzheimer's disease; CRC cis rs17376456 0.877 rs10044139 chr5:93407803 T/C cg21475434 chr5:93447410 FAM172A 0.74 7.56 0.38 4.17e-13 Diabetic retinopathy; CRC cis rs8180040 0.800 rs11920354 chr3:47262246 C/A cg02527881 chr3:46936655 PTH1R 0.36 6.31 0.33 9.13e-10 Colorectal cancer; CRC cis rs7804356 0.953 rs3823928 chr7:26893317 T/C cg03456212 chr7:26904342 SKAP2 -0.49 -5.63 -0.3 3.96e-8 Type 1 diabetes; CRC trans rs10802346 0.545 rs12134404 chr1:246372144 A/G cg13514129 chr1:39547527 MACF1 0.57 8.58 0.43 3.74e-16 Fractional exhaled nitric oxide (childhood); CRC cis rs9914988 0.673 rs12325788 chr17:27080049 G/A cg19196414 chr17:27188595 MIR451;MIR144 0.38 5.69 0.3 2.8e-8 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs2841277 0.708 rs10083496 chr14:105402786 G/A cg14403583 chr14:105418241 AHNAK2 -0.33 -5.93 -0.31 7.78e-9 Rheumatoid arthritis; CRC cis rs801193 1.000 rs1553609 chr7:66197139 T/C cg18876405 chr7:65276391 NA 0.6 10.62 0.51 7.84e-23 Aortic root size; CRC cis rs7617773 0.780 rs34630841 chr3:48343261 G/A cg11946769 chr3:48343235 NME6 0.74 9.88 0.48 2.56e-20 Coronary artery disease; CRC cis rs10971721 0.642 rs10971736 chr9:33854374 A/G cg13495928 chr9:33750294 PRSS3 0.55 5.9 0.31 9.17e-9 Body mass index; CRC cis rs2802369 1 rs2802369 chr10:80960828 C/A cg20744163 chr10:80999841 ZMIZ1 -0.43 -7.37 -0.38 1.37e-12 Response to methotrexate in juvenile idiopathic arthritis; CRC cis rs28386778 0.765 rs2070680 chr17:61986988 A/G cg06873352 chr17:61820015 STRADA -0.6 -10.8 -0.51 1.85e-23 Prudent dietary pattern; CRC cis rs7647973 1.000 rs9862534 chr3:49598064 A/G cg07636037 chr3:49044803 WDR6 0.64 7.89 0.4 4.37e-14 Menarche (age at onset); CRC cis rs9522267 0.535 rs7323631 chr13:112232269 A/G cg26182253 chr13:112236782 NA 0.31 6.25 0.33 1.26e-9 Hepatitis; CRC trans rs12699921 0.598 rs2723505 chr7:17854849 C/T cg15753394 chr6:17282781 RBM24 -0.36 -6.03 -0.32 4.5e-9 Fibrinogen levels; CRC cis rs9487051 0.714 rs7757347 chr6:109633815 G/A cg12927641 chr6:109611667 NA -0.36 -6.31 -0.33 8.94e-10 Reticulocyte fraction of red cells; CRC cis rs11630290 1.000 rs72750990 chr15:64005333 C/T cg12036633 chr15:63758958 NA -0.56 -5.81 -0.3 1.51e-8 Iris characteristics; CRC cis rs10411161 0.702 rs6509592 chr19:52393150 G/A cg06878361 chr19:52390810 ZNF577 0.47 5.61 0.3 4.31e-8 Breast cancer; CRC cis rs7072216 0.587 rs3814141 chr10:100171028 G/A cg26618903 chr10:100175079 PYROXD2 -0.52 -8.17 -0.41 6.61e-15 Metabolite levels; CRC cis rs7613875 0.600 rs7061 chr3:50114515 C/T cg24110177 chr3:50126178 RBM5 0.53 7.97 0.4 2.64e-14 Body mass index; CRC trans rs1814175 0.669 rs11040473 chr11:49703813 C/T cg21153622 chr11:89784906 NA -0.42 -6.98 -0.36 1.64e-11 Height; CRC trans rs10435719 0.902 rs12681142 chr8:11802601 T/C cg06636001 chr8:8085503 FLJ10661 0.49 7.52 0.38 5.38e-13 C-reactive protein levels or triglyceride levels (pleiotropy); CRC cis rs765787 0.530 rs2433228 chr15:45515371 A/C cg24006582 chr15:45444508 DUOX1 -0.57 -8.75 -0.43 1.15e-16 Uric acid levels; CRC cis rs12586317 0.513 rs11156871 chr14:35481196 G/A cg16230307 chr14:35515116 FAM177A1 0.86 9.89 0.48 2.29e-20 Psoriasis; CRC cis rs9388451 0.626 rs1935983 chr6:126068914 C/T cg05901451 chr6:126070800 HEY2 -0.54 -9.01 -0.44 1.69e-17 Brugada syndrome; CRC cis rs1355223 0.583 rs2915179 chr11:34871943 C/T cg11058730 chr11:34937778 PDHX;APIP 0.72 11.62 0.54 2.14e-26 Systemic lupus erythematosus and Systemic sclerosis; CRC cis rs6598955 0.671 rs17163868 chr1:26648381 A/G cg00852783 chr1:26633632 UBXN11 0.48 5.84 0.31 1.24e-8 Obesity-related traits; CRC cis rs9308731 0.688 rs4302219 chr2:111880284 G/T cg04202892 chr2:111875749 ACOXL 0.47 7.64 0.39 2.32e-13 Chronic lymphocytic leukemia; CRC cis rs9443645 0.869 rs9443626 chr6:79629564 G/C cg09184832 chr6:79620586 NA -0.49 -9.0 -0.44 1.83e-17 Intelligence (multi-trait analysis); CRC cis rs6694672 1.000 rs1412639 chr1:197003593 G/A cg13682187 chr1:196946512 CFHR5 0.6 8.91 0.44 3.68e-17 Asthma; CRC cis rs2153535 0.580 rs1328862 chr6:8526681 A/T cg07606381 chr6:8435919 SLC35B3 0.67 10.99 0.52 3.99e-24 Motion sickness; CRC cis rs3126085 0.877 rs2338431 chr1:152169305 A/G cg09127314 chr1:152161683 NA 0.49 6.15 0.32 2.29e-9 Atopic dermatitis; CRC cis rs13108904 0.967 rs1316419 chr4:1293997 C/T cg00684032 chr4:1343700 KIAA1530 0.47 6.79 0.35 5.23e-11 Obesity-related traits; CRC cis rs7177699 0.557 rs7178051 chr15:79118296 A/G cg00540400 chr15:79124168 NA 0.3 5.61 0.3 4.41e-8 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; CRC cis rs11098499 0.588 rs2389874 chr4:120554991 A/G cg24375607 chr4:120327624 NA -0.41 -6.58 -0.34 1.9e-10 Corneal astigmatism; CRC cis rs4409675 0.576 rs12070659 chr1:28227175 G/A cg23691781 chr1:28212827 C1orf38 0.31 7.17 0.37 4.98e-12 Corneal astigmatism; CRC cis rs561341 0.882 rs2521594 chr17:30302087 C/T cg12193833 chr17:30244370 NA -0.73 -8.62 -0.43 2.95e-16 Hip circumference adjusted for BMI; CRC cis rs2996428 0.667 rs61768933 chr1:3766587 G/A cg22529645 chr1:3704559 LRRC47 0.43 5.79 0.3 1.68e-8 Red cell distribution width; CRC cis rs2032447 0.839 rs6901039 chr6:26000885 A/C cg18357526 chr6:26021779 HIST1H4A 0.69 10.57 0.5 1.12e-22 Intelligence (multi-trait analysis); CRC cis rs6433857 0.534 rs1157535 chr2:181361736 T/A cg23363182 chr2:181467187 NA -0.55 -8.03 -0.4 1.74e-14 Body mass index; CRC cis rs10927875 0.688 rs2009371 chr1:16348083 A/T cg21385522 chr1:16154831 NA 0.61 7.58 0.39 3.6e-13 Dilated cardiomyopathy; CRC cis rs929354 0.605 rs7806314 chr7:156946903 A/T cg05182265 chr7:156933206 UBE3C -0.76 -14.38 -0.62 1.04e-36 Body mass index; CRC cis rs7618501 0.669 rs7634084 chr3:49949834 A/T cg24110177 chr3:50126178 RBM5 -0.51 -7.89 -0.4 4.41e-14 Intelligence (multi-trait analysis); CRC trans rs11098499 0.954 rs4577559 chr4:120404043 T/G cg25214090 chr10:38739885 LOC399744 0.65 10.37 0.5 5.64e-22 Corneal astigmatism; CRC cis rs7917772 0.505 rs61869211 chr10:104449836 A/G cg04362960 chr10:104952993 NT5C2 -0.5 -6.13 -0.32 2.57e-9 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC cis rs4969178 0.620 rs7219625 chr17:76390080 C/T cg02319466 chr17:76381040 PGS1 0.37 5.78 0.3 1.78e-8 HDL cholesterol levels; CRC trans rs3780486 0.718 rs7859454 chr9:33119583 T/A cg04842962 chr6:43655489 MRPS18A 0.94 11.44 0.53 9.89e-26 IgG glycosylation; CRC cis rs7772486 0.875 rs7761033 chr6:146356106 C/T cg23711669 chr6:146136114 FBXO30 0.68 11.85 0.55 3.11e-27 Lobe attachment (rater-scored or self-reported); CRC cis rs55702914 0.650 rs6715690 chr2:198148371 C/T cg20885578 chr2:198174922 NA -0.34 -5.96 -0.31 6.49e-9 Major depression and alcohol dependence; CRC cis rs9435341 0.930 rs2232015 chr1:107599258 A/T cg15468180 chr1:107600409 PRMT6 0.45 6.73 0.35 7.76e-11 Facial morphology (factor 21, depth of nasal alae); CRC trans rs4724055 0.557 rs539401 chr7:41620806 G/A cg21883598 chr15:45404157 DUOX2 0.48 5.96 0.31 6.55e-9 Non-substance related behavioral disinhibition; CRC cis rs9527 0.615 rs9733635 chr10:104711940 G/A cg15744005 chr10:104629667 AS3MT -0.31 -6.22 -0.32 1.51e-9 Arsenic metabolism; CRC trans rs1455244 0.700 rs7229302 chr18:11508904 G/T cg23075269 chr19:18304032 MPV17L2 0.38 6.04 0.32 4.25e-9 Schizophrenia; CRC cis rs4862750 0.758 rs2375915 chr4:187896255 A/C cg10295955 chr4:187884368 NA -1.03 -25.58 -0.82 3.3e-80 Lobe attachment (rater-scored or self-reported); CRC cis rs17155006 0.746 rs435125 chr7:107748934 A/G cg05962710 chr7:107745446 LAMB4 -0.41 -7.44 -0.38 8.61e-13 Pneumococcal bacteremia; CRC cis rs3768617 0.745 rs4546885 chr1:183025555 C/G ch.1.3577855R chr1:183094577 LAMC1 0.59 8.71 0.43 1.53e-16 Fuchs's corneal dystrophy; CRC cis rs4234284 0.556 rs4679147 chr3:126955702 C/T cg27326032 chr3:127006922 NA -0.52 -7.49 -0.38 6.52e-13 Adverse response to chemotherapy in breast cancer (alopecia) (docetaxel); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg17728987 chr19:36485959 SDHAF1 0.46 6.71 0.35 8.39e-11 Intelligence (multi-trait analysis); CRC cis rs6541297 1.000 rs6541296 chr1:230281953 A/G cg20703242 chr1:230279135 GALNT2 0.51 7.66 0.39 2.08e-13 Coronary artery disease; CRC trans rs16846053 0.681 rs62187563 chr2:162354653 G/A cg18122310 chr12:50236657 BCDIN3D -0.72 -6.07 -0.32 3.53e-9 Blood osmolality (transformed sodium); CRC cis rs5769707 1.000 rs5769707 chr22:50013402 G/T cg20744362 chr22:50050164 C22orf34 0.34 6.78 0.35 5.64e-11 Monocyte count;Monocyte percentage of white cells; CRC cis rs72615157 0.634 rs74742883 chr7:99785765 T/G cg00814883 chr7:100076585 TSC22D4 -0.51 -6.11 -0.32 2.82e-9 Lung function (FEV1/FVC); CRC cis rs4689388 0.890 rs4688991 chr4:6302220 C/G cg00701064 chr4:6280414 WFS1 0.78 13.93 0.61 5.21e-35 Type 2 diabetes and other traits;Type 2 diabetes; CRC trans rs2814331 0.607 rs1902678 chr10:88006634 C/G cg11798182 chr14:98444513 C14orf64 0.65 5.99 0.31 5.62e-9 Balding; CRC cis rs6598955 0.671 rs58038522 chr1:26582713 C/T cg04990556 chr1:26633338 UBXN11 0.56 6.02 0.32 4.53e-9 Obesity-related traits; CRC cis rs743757 1.000 rs734767 chr3:50431410 C/G cg09545109 chr3:50388910 TUSC4;CYB561D2 0.4 5.77 0.3 1.79e-8 Diastolic blood pressure; CRC cis rs4803455 0.586 rs4803457 chr19:41861359 T/C cg09537434 chr19:41945824 ATP5SL -0.57 -8.46 -0.42 8.72e-16 Migraine;Coronary artery disease; CRC trans rs208520 0.526 rs7776413 chr6:66783241 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.16 -25.31 -0.81 3.19e-79 Exhaled nitric oxide output; CRC cis rs72781680 0.699 rs72796125 chr2:23919169 C/T cg08917208 chr2:24149416 ATAD2B 0.99 9.16 0.45 5.85e-18 Lymphocyte counts; CRC cis rs10504229 1.000 rs3814486 chr8:58191226 A/T cg24829409 chr8:58192753 C8orf71 -0.68 -11.34 -0.53 2.27e-25 Developmental language disorder (linguistic errors); CRC cis rs6502050 0.835 rs6502079 chr17:80124454 T/A cg02741985 chr17:80059408 CCDC57 0.43 7.15 0.37 5.59e-12 Life satisfaction; CRC cis rs2692947 0.732 rs56847058 chr2:96406893 C/T cg23100626 chr2:96804247 ASTL 0.26 6.91 0.36 2.58e-11 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; CRC cis rs11992186 0.505 rs7845203 chr8:8145440 A/G cg08975724 chr8:8085496 FLJ10661 0.42 6.45 0.33 4.09e-10 Neuroticism; CRC cis rs12477438 0.684 rs6756880 chr2:99676991 A/T cg14399236 chr2:99771627 LIPT1;TSGA10 -0.6 -8.19 -0.41 6.03e-15 Chronic sinus infection; CRC cis rs2737618 0.674 rs2737684 chr1:200092951 C/T cg21825944 chr1:200113062 NR5A2 -0.52 -7.5 -0.38 6.06e-13 Uric acid levels; CRC cis rs6598955 0.572 rs6598951 chr1:26592714 G/T cg04990556 chr1:26633338 UBXN11 0.55 5.94 0.31 7.29e-9 Obesity-related traits; CRC cis rs2836974 0.583 rs2776306 chr21:40713754 A/G cg11644478 chr21:40555479 PSMG1 0.48 7.09 0.36 8.2e-12 Cognitive function; CRC cis rs875971 0.825 rs7384021 chr7:66077904 A/G cg12463550 chr7:65579703 CRCP -0.47 -6.3 -0.33 9.38e-10 Aortic root size; CRC cis rs6121246 0.567 rs6060260 chr20:30192907 C/T cg18721089 chr20:30220636 NA -0.52 -7.93 -0.4 3.54e-14 Mean corpuscular hemoglobin; CRC cis rs2050392 0.792 rs684395 chr10:30719112 C/G cg25182066 chr10:30743637 MAP3K8 -0.41 -6.02 -0.31 4.72e-9 Inflammatory bowel disease; CRC cis rs10905065 0.827 rs10752111 chr10:5837286 T/C cg11519256 chr10:5708881 ASB13 0.52 7.77 0.39 1.04e-13 Menopause (age at onset); CRC cis rs55871839 0.684 rs4738729 chr8:59808617 T/C cg07426533 chr8:59803705 TOX -0.34 -5.93 -0.31 7.82e-9 Pneumonia; CRC cis rs929596 0.597 rs10173355 chr2:234597321 A/T cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.51 -7.57 -0.39 3.73e-13 Total bilirubin levels in HIV-1 infection; CRC cis rs10791323 0.628 rs2851118 chr11:133705995 A/C cg00579200 chr11:133705235 NA -0.41 -5.96 -0.31 6.32e-9 Childhood ear infection; CRC cis rs1448094 0.556 rs11611968 chr12:86168022 G/A cg02569458 chr12:86230093 RASSF9 0.49 8.05 0.41 1.48e-14 Major depressive disorder; CRC trans rs4308415 0.781 rs6857547 chr4:67808453 A/G cg19648955 chr2:177134095 MTX2 -0.42 -6.2 -0.32 1.68e-9 Educational attainment (years of education); CRC trans rs3780486 0.541 rs10738909 chr9:33148834 T/C cg20290983 chr6:43655470 MRPS18A 0.95 17.24 0.69 6.44e-48 IgG glycosylation; CRC trans rs1997103 1.000 rs2177803 chr7:55410773 A/G cg20935933 chr6:143382018 AIG1 0.51 6.65 0.34 1.25e-10 QRS interval (sulfonylurea treatment interaction); CRC cis rs2050392 1.000 rs2183176 chr10:30698544 C/T cg18806716 chr10:30721971 MAP3K8 0.45 6.99 0.36 1.51e-11 Inflammatory bowel disease; CRC cis rs10504229 0.906 rs114810777 chr8:58185298 A/G cg05313129 chr8:58192883 C8orf71 -0.47 -6.95 -0.36 2e-11 Developmental language disorder (linguistic errors); CRC cis rs7618915 0.547 rs2268027 chr3:52766606 G/A cg18404041 chr3:52824283 ITIH1 -0.43 -8.89 -0.44 4.01e-17 Bipolar disorder; CRC cis rs1707322 0.752 rs11211146 chr1:46109794 T/C cg03146154 chr1:46216737 IPP 0.67 9.83 0.48 3.62e-20 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC trans rs1814175 0.502 rs12365889 chr11:49623034 G/A cg11707556 chr5:10655725 ANKRD33B -0.45 -7.4 -0.38 1.16e-12 Height; CRC cis rs6570726 0.764 rs1912023 chr6:145824278 C/A cg23711669 chr6:146136114 FBXO30 0.74 12.97 0.58 2.27e-31 Lobe attachment (rater-scored or self-reported); CRC cis rs4713118 0.540 rs469227 chr6:27970705 A/C cg15845792 chr6:28175446 NA 0.8 11.85 0.55 3.12e-27 Parkinson's disease; CRC cis rs6662572 0.737 rs6429579 chr1:46258193 T/C cg08644498 chr1:46502608 NA -0.36 -5.98 -0.31 5.91e-9 Blood protein levels; CRC trans rs11581859 0.950 rs72728601 chr1:99369685 C/T cg12183875 chr3:169587454 LRRC31 0.26 6.13 0.32 2.55e-9 Response to cognitive-behavioural therapy in anxiety disorder; CRC cis rs853679 0.517 rs36078605 chr6:28078032 A/C cg12963246 chr6:28129442 ZNF389 0.51 5.86 0.31 1.13e-8 Depression; CRC cis rs79349575 0.783 rs28409394 chr17:46998118 T/C cg22482690 chr17:47019901 SNF8 0.49 8.2 0.41 5.6e-15 Type 2 diabetes; CRC cis rs9992667 0.955 rs12507197 chr4:38663660 T/C cg19726192 chr4:38663646 FLJ13197 -0.71 -9.02 -0.45 1.62e-17 Eosinophil percentage of granulocytes; CRC cis rs7647973 1.000 rs6785045 chr3:49435243 G/C cg07636037 chr3:49044803 WDR6 -0.65 -7.81 -0.4 7.8e-14 Menarche (age at onset); CRC cis rs66887589 0.967 rs6844263 chr4:120433807 A/G cg09307838 chr4:120376055 NA 0.53 8.22 0.41 4.91e-15 Diastolic blood pressure; CRC cis rs17401966 1.000 rs17410793 chr1:10391886 A/G cg19773385 chr1:10388646 KIF1B -0.58 -7.85 -0.4 5.73e-14 Hepatocellular carcinoma; CRC cis rs3823572 0.542 rs10271889 chr7:133635846 A/G cg03336402 chr7:133662267 EXOC4 0.67 10.32 0.49 8.37e-22 Intelligence (multi-trait analysis); CRC cis rs9325144 0.555 rs10748433 chr12:38696352 C/G cg13010199 chr12:38710504 ALG10B 0.43 6.31 0.33 9.27e-10 Morning vs. evening chronotype; CRC cis rs5758511 0.573 rs2267438 chr22:42237565 C/T cg00645731 chr22:42541494 CYP2D7P1 -0.37 -6.06 -0.32 3.82e-9 Birth weight; CRC cis rs61332075 0.540 rs55986470 chr2:239363773 A/G cg18131467 chr2:239335373 ASB1 -0.64 -6.76 -0.35 6.4e-11 Lung function (FEV1/FVC); CRC cis rs877282 0.682 rs2265092 chr10:780293 C/T cg17470449 chr10:769945 NA -0.38 -6.28 -0.33 1.08e-9 Uric acid levels; CRC trans rs3733585 0.699 rs6449179 chr4:9969117 G/A cg26043149 chr18:55253948 FECH -0.49 -7.5 -0.38 6.14e-13 Cleft plate (environmental tobacco smoke interaction); CRC cis rs728616 0.681 rs36073865 chr10:81916055 C/T cg05935833 chr10:81318306 SFTPA2 -0.49 -5.94 -0.31 7.29e-9 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs6842047 1.000 rs72647308 chr4:187135129 G/A cg09526685 chr4:187126073 CYP4V2 -0.48 -6.82 -0.35 4.38e-11 Blood protein levels; CRC cis rs66887589 0.967 rs3775842 chr4:120427732 G/A cg09307838 chr4:120376055 NA 0.54 8.27 0.41 3.36e-15 Diastolic blood pressure; CRC trans rs2243480 0.615 rs34363376 chr7:65939536 T/C cg10756647 chr7:56101905 PSPH 0.74 7.48 0.38 7.04e-13 Diabetic kidney disease; CRC trans rs2228479 0.850 rs76075456 chr16:89834270 T/C cg24644049 chr4:85504048 CDS1 0.87 7.11 0.36 7.24e-12 Skin colour saturation; CRC cis rs7552404 0.924 rs67757078 chr1:76169456 G/A cg22875332 chr1:76189707 ACADM 0.76 11.12 0.52 1.31e-24 Blood metabolite levels;Acylcarnitine levels; CRC cis rs6662572 1.000 rs11587982 chr1:46161868 A/T cg08644498 chr1:46502608 NA 0.45 6.56 0.34 2.15e-10 Blood protein levels; CRC trans rs629535 0.773 rs686683 chr8:70070364 G/A cg21567404 chr3:27674614 NA 0.93 15.32 0.65 2.37e-40 Dupuytren's disease; CRC cis rs9462027 0.628 rs6906759 chr6:34742990 G/A cg07306190 chr6:34760872 UHRF1BP1 -0.35 -6.24 -0.33 1.36e-9 Systemic lupus erythematosus; CRC cis rs7258465 1.000 rs10425982 chr19:18586519 T/A cg01065977 chr19:18549689 ISYNA1 -0.41 -6.35 -0.33 7.03e-10 Breast cancer; CRC cis rs2688608 0.592 rs3849967 chr10:75483366 C/T cg16540259 chr10:75572220 NDST2 0.38 5.98 0.31 5.91e-9 Inflammatory bowel disease; CRC cis rs7811142 0.887 rs111972532 chr7:100069088 T/C cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.7 9.14 0.45 6.79e-18 Platelet count; CRC cis rs77633900 0.614 rs2439984 chr15:76923917 T/C cg21673338 chr15:77095150 SCAPER -0.76 -8.03 -0.4 1.79e-14 Non-glioblastoma glioma;Glioma; CRC cis rs929596 0.564 rs2741024 chr2:234517745 G/A cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.43 -5.7 -0.3 2.62e-8 Total bilirubin levels in HIV-1 infection; CRC cis rs6963495 0.818 rs73190183 chr7:105163022 G/A cg02135003 chr7:105160482 PUS7 -0.9 -12.2 -0.56 1.71e-28 Bipolar disorder (body mass index interaction); CRC cis rs11098499 0.738 rs10026493 chr4:120384194 C/G cg09307838 chr4:120376055 NA 0.71 10.92 0.52 6.75e-24 Corneal astigmatism; CRC cis rs4481887 1.000 rs7511706 chr1:248467360 G/A cg13385794 chr1:248469461 NA 0.38 6.8 0.35 5.07e-11 Common traits (Other); CRC cis rs2282032 0.527 rs2282033 chr14:90769635 G/T cg14092571 chr14:90743983 NA -0.46 -7.02 -0.36 1.24e-11 Longevity; CRC cis rs939584 0.866 rs13387090 chr2:650974 G/T cg03610516 chr2:642275 NA -0.42 -5.89 -0.31 9.46e-9 Body mass index; CRC cis rs9443645 0.803 rs12195716 chr6:79535412 T/C cg11833968 chr6:79620685 NA -0.35 -6.08 -0.32 3.35e-9 Intelligence (multi-trait analysis); CRC cis rs11098499 0.874 rs12502503 chr4:120116255 C/T cg24375607 chr4:120327624 NA 0.48 7.25 0.37 3.02e-12 Corneal astigmatism; CRC cis rs3761218 0.738 rs6084472 chr20:3771858 G/T cg25011176 chr20:3776985 CDC25B -0.39 -5.65 -0.3 3.5e-8 Bipolar disorder; CRC cis rs6840360 1.000 rs6817586 chr4:152643184 G/A cg09659197 chr4:152720779 NA 0.53 11.62 0.54 2.26e-26 Intelligence (multi-trait analysis); CRC cis rs7107174 1.000 rs10899489 chr11:78095373 G/T cg02023728 chr11:77925099 USP35 0.43 7.24 0.37 3.27e-12 Testicular germ cell tumor; CRC cis rs4589502 1.000 rs8023363 chr15:67154654 G/A cg09911534 chr15:67153556 NA -0.52 -5.67 -0.3 3.18e-8 Lung cancer (smoking interaction); CRC cis rs16852403 0.502 rs6682970 chr1:178170520 A/G cg00404053 chr1:178313656 RASAL2 0.5 6.59 0.34 1.75e-10 Childhood ear infection; CRC cis rs875971 0.619 rs10278371 chr7:66051540 C/A cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.43 -6.24 -0.33 1.34e-9 Aortic root size; CRC trans rs9291683 0.679 rs13137795 chr4:10051506 G/A cg26043149 chr18:55253948 FECH 0.56 8.72 0.43 1.38e-16 Bone mineral density; CRC cis rs7044106 0.791 rs2416799 chr9:123480866 G/T cg09419670 chr9:123605666 PSMD5;LOC253039 0.75 12.27 0.56 9.17e-29 Hip circumference adjusted for BMI; CRC cis rs853679 0.882 rs2743555 chr6:28241081 G/A cg15786705 chr6:28176104 NA 0.59 6.05 0.32 3.84e-9 Depression; CRC cis rs1609391 0.543 rs1347209 chr3:136626697 G/T cg15507776 chr3:136538369 TMEM22 0.34 6.15 0.32 2.24e-9 Neuroticism; CRC cis rs9660180 0.783 rs1107910 chr1:1692321 C/T cg17747265 chr1:1875780 NA -0.61 -10.17 -0.49 2.72e-21 Body mass index; CRC cis rs1129187 0.755 rs9471982 chr6:42935998 G/A cg03790207 chr6:42947109 PEX6 -0.53 -7.76 -0.39 1.1e-13 Alzheimer's disease in APOE e4+ carriers; CRC cis rs8060686 0.641 rs79375669 chr16:68099262 A/T cg08314208 chr16:67682810 RLTPR -0.57 -6.12 -0.32 2.72e-9 HDL cholesterol;Metabolic syndrome; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg09440018 chr17:7475963 EIF4A1 0.45 6.34 0.33 7.37e-10 Intelligence (multi-trait analysis); CRC cis rs9818758 0.607 rs34784192 chr3:49274823 G/T cg07636037 chr3:49044803 WDR6 -0.7 -6.07 -0.32 3.56e-9 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; CRC cis rs2243480 1.000 rs1499613 chr7:65730860 G/A cg25985355 chr7:65971099 NA 0.51 5.72 0.3 2.46e-8 Diabetic kidney disease; CRC cis rs9303401 0.659 rs12602389 chr17:56779778 G/A cg10487724 chr17:56770010 TEX14;RAD51C 0.79 10.0 0.48 1.01e-20 Cognitive test performance; CRC trans rs800082 0.867 rs2717393 chr3:144280290 T/C cg24215973 chr2:240111563 HDAC4 0.52 6.94 0.36 2.11e-11 Smoking behavior; CRC cis rs896854 0.530 rs10956934 chr8:95992473 C/A cg16049864 chr8:95962084 TP53INP1 -0.64 -11.49 -0.54 6.3e-26 Type 2 diabetes; CRC cis rs1799949 0.930 rs3765640 chr17:41276247 A/G cg05368731 chr17:41323189 NBR1 0.69 10.48 0.5 2.22e-22 Menopause (age at onset); CRC cis rs4481887 0.861 rs4644528 chr1:248472508 T/A cg00666640 chr1:248458726 OR2T12 0.45 7.8 0.4 8.31e-14 Common traits (Other); CRC cis rs5769765 0.908 rs9616390 chr22:50314289 G/C cg08270630 chr22:50330655 NA -0.4 -5.71 -0.3 2.47e-8 Schizophrenia; CRC trans rs116095464 0.558 rs12173244 chr5:269524 G/A cg00938859 chr5:1591904 SDHAP3 0.73 7.92 0.4 3.76e-14 Breast cancer; CRC cis rs4722166 0.598 rs4722178 chr7:22798650 T/C cg05472934 chr7:22766657 IL6 0.64 10.52 0.5 1.65e-22 Lung cancer; CRC trans rs7824557 0.564 rs2736294 chr8:11234626 T/C cg06636001 chr8:8085503 FLJ10661 -0.45 -6.85 -0.35 3.68e-11 Retinal vascular caliber; CRC cis rs7762018 1.000 rs17860606 chr6:170099561 G/A cg24289452 chr6:170231220 NA -0.6 -6.56 -0.34 2.09e-10 Thiazide-induced adverse metabolic effects in hypertensive patients; CRC cis rs853679 0.517 rs9393890 chr6:28063855 C/T cg18032046 chr6:28092343 ZSCAN16 -0.5 -5.89 -0.31 9.34e-9 Depression; CRC cis rs1448094 0.872 rs7975457 chr12:86410404 C/T cg18827107 chr12:86230957 RASSF9 -0.36 -5.77 -0.3 1.83e-8 Major depressive disorder; CRC cis rs10504229 0.610 rs6987118 chr8:58147851 G/T cg02725872 chr8:58115012 NA -0.6 -11.24 -0.53 5.19e-25 Developmental language disorder (linguistic errors); CRC cis rs9916302 0.808 rs12947281 chr17:37652210 G/T cg15445000 chr17:37608096 MED1 0.43 9.46 0.46 6.14e-19 Glomerular filtration rate (creatinine); CRC cis rs4660306 0.848 rs1088099 chr1:45946654 T/C cg03123370 chr1:45965343 CCDC163P;MMACHC 0.54 7.39 0.38 1.23e-12 Homocysteine levels; CRC cis rs7927592 0.731 rs2840367 chr11:68302101 G/A cg01657329 chr11:68192670 LRP5 0.56 9.22 0.45 3.74e-18 Total body bone mineral density; CRC cis rs8180040 0.800 rs11921117 chr3:47294000 T/C cg27129171 chr3:47204927 SETD2 -0.66 -9.98 -0.48 1.13e-20 Colorectal cancer; CRC trans rs2727020 0.930 rs1164688 chr11:49290604 C/G cg15704280 chr7:45808275 SEPT13 0.72 10.13 0.49 3.57e-21 Coronary artery disease; CRC cis rs412000 0.507 rs2680688 chr17:56450524 T/C cg12560992 chr17:57184187 TRIM37 -0.48 -6.42 -0.33 4.82e-10 Primary tooth development (time to first tooth eruption); CRC cis rs79387448 0.638 rs7600961 chr2:103035455 G/A cg09003973 chr2:102972529 NA 0.76 8.35 0.42 1.89e-15 Gut microbiota (bacterial taxa); CRC cis rs10924970 0.601 rs12024609 chr1:235452167 G/A cg09010748 chr1:235293032 TOMM20 -0.4 -5.66 -0.3 3.26e-8 Asthma; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg08204369 chr17:73150733 HN1 0.51 7.27 0.37 2.56e-12 Response to antipsychotic treatment; CRC cis rs1552244 1.000 rs9824585 chr3:10114802 T/C cg10729496 chr3:10149963 C3orf24 0.5 6.74 0.35 7.23e-11 Alzheimer's disease; CRC cis rs644799 1.000 rs525404 chr11:95566520 A/G cg25622487 chr11:95524042 FAM76B;CEP57 0.76 11.85 0.55 3.12e-27 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs13108904 0.967 rs62293658 chr4:1276416 T/C cg24560729 chr4:1342394 KIAA1530 -0.33 -6.18 -0.32 1.84e-9 Obesity-related traits; CRC cis rs11608355 0.515 rs35691047 chr12:109932585 C/T cg05360138 chr12:110035743 NA 0.77 8.64 0.43 2.48e-16 Neuroticism; CRC trans rs6557786 0.636 rs17052934 chr8:24840319 A/C cg10354845 chr8:30013713 DCTN6 0.47 6.08 0.32 3.32e-9 Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 2 peripheral neuropathy); CRC cis rs823143 0.570 rs1361754 chr1:205801872 C/T cg24503407 chr1:205819492 PM20D1 -0.65 -10.31 -0.49 9.01e-22 Monocyte percentage of white cells; CRC cis rs3741151 0.773 rs6592526 chr11:73208911 C/T cg17517138 chr11:73019481 ARHGEF17 1.01 8.32 0.42 2.41e-15 GIP levels in response to oral glucose tolerance test (120 minutes); CRC cis rs2836950 0.565 rs2836930 chr21:40545656 A/G cg06238570 chr21:40685208 BRWD1 -0.63 -9.29 -0.46 2.2e-18 Menarche (age at onset); CRC cis rs595982 0.527 rs55670257 chr19:49382654 G/A cg15549821 chr19:49342101 PLEKHA4 -0.57 -6.27 -0.33 1.11e-9 Red cell distribution width; CRC cis rs2439831 1.000 rs7173487 chr15:43750239 A/G cg02155558 chr15:43621948 ADAL;LCMT2 0.75 8.31 0.42 2.55e-15 Lung cancer in ever smokers; CRC cis rs13256369 0.851 rs13267036 chr8:8566685 G/A cg18904891 chr8:8559673 CLDN23 0.54 7.12 0.37 6.68e-12 Obesity-related traits; CRC cis rs35306767 0.668 rs35657988 chr10:1103590 A/G cg20503657 chr10:835505 NA 0.61 8.16 0.41 6.98e-15 Eosinophil percentage of granulocytes; CRC cis rs6952808 0.594 rs3778965 chr7:2138296 G/A cg04267008 chr7:1944627 MAD1L1 -0.67 -9.28 -0.46 2.28e-18 Bipolar disorder and schizophrenia; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg16529440 chr12:93323219 EEA1 0.36 6.0 0.31 5.26e-9 Liver disease severity in Alagille syndrome; CRC cis rs6743376 0.556 rs6748448 chr2:113819419 A/G cg24553058 chr2:113831203 IL1F10 0.43 6.96 0.36 1.81e-11 Inflammatory biomarkers; CRC cis rs10242455 1.000 rs2301889 chr7:98931105 A/G cg18809830 chr7:99032528 PTCD1 -0.71 -6.2 -0.32 1.67e-9 Blood metabolite levels; CRC cis rs9611565 0.545 rs5758432 chr22:42111693 T/C cg06634786 chr22:41940651 POLR3H 0.63 7.11 0.37 7.11e-12 Vitiligo; CRC cis rs847577 0.748 rs940431 chr7:97716495 C/T cg21770322 chr7:97807741 LMTK2 0.84 18.44 0.71 1.18e-52 Breast cancer; CRC cis rs13118159 0.505 rs1250128 chr4:1257311 T/C cg16405210 chr4:1374714 KIAA1530 0.9 13.45 0.6 3.5e-33 Longevity; CRC cis rs7940866 0.838 rs12790299 chr11:130803634 A/G cg12179176 chr11:130786555 SNX19 0.62 8.89 0.44 4.06e-17 Schizophrenia; CRC cis rs6860806 0.507 rs272883 chr5:131668698 A/G cg02033258 chr5:131593261 PDLIM4 0.37 6.38 0.33 6.02e-10 Breast cancer; CRC cis rs10256972 0.591 rs11766651 chr7:1161646 A/G cg07092213 chr7:1199455 ZFAND2A -0.45 -6.46 -0.34 3.73e-10 Longevity;Endometriosis; CRC cis rs1577917 0.876 rs12212808 chr6:86533972 T/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.49 -6.58 -0.34 1.82e-10 Response to antipsychotic treatment; CRC cis rs6565180 0.507 rs4471699 chr16:30320307 G/T cg17640201 chr16:30407289 ZNF48 -0.49 -7.34 -0.38 1.65e-12 Tonsillectomy; CRC cis rs1124376 0.816 rs62243131 chr3:20141308 A/G cg05072819 chr3:20081367 KAT2B 0.46 5.76 0.3 1.91e-8 Bipolar disorder and schizophrenia; CRC cis rs2836974 0.568 rs429955 chr21:40539760 G/A cg17971929 chr21:40555470 PSMG1 0.74 11.84 0.55 3.57e-27 Cognitive function; CRC cis rs10788264 0.569 rs10749454 chr10:124029654 C/T cg09507567 chr10:124027408 NA 0.34 7.54 0.38 4.55e-13 Total body bone mineral density; CRC cis rs6502050 0.799 rs7502533 chr17:80109778 A/G cg19223190 chr17:80058835 NA 0.4 6.36 0.33 6.88e-10 Life satisfaction; CRC cis rs950169 0.919 rs12915589 chr15:84734464 T/C cg24253500 chr15:84953950 NA 0.37 6.18 0.32 1.92e-9 Schizophrenia; CRC cis rs394563 0.591 rs237026 chr6:149720681 G/A cg03678062 chr6:149772716 ZC3H12D -0.37 -6.72 -0.35 7.94e-11 Dupuytren's disease; CRC cis rs6570726 0.791 rs6570695 chr6:145911286 C/A cg05347473 chr6:146136440 FBXO30 0.38 5.71 0.3 2.52e-8 Lobe attachment (rater-scored or self-reported); CRC cis rs9303401 0.614 rs2007993 chr17:56590643 T/C cg10487724 chr17:56770010 TEX14;RAD51C 0.79 9.6 0.47 2.14e-19 Cognitive test performance; CRC cis rs17234274 0.622 rs4598669 chr11:23236615 C/G cg05245346 chr11:23248277 NA 0.34 5.63 0.3 3.79e-8 Cancer; CRC cis rs526821 0.574 rs11230156 chr11:55334809 A/G cg04317927 chr11:55418816 OR4S2 0.39 6.56 0.34 2.06e-10 Pediatric bone mineral density (spine); CRC cis rs270601 0.690 rs162904 chr5:131595784 C/T cg18758796 chr5:131593413 PDLIM4 -0.46 -7.6 -0.39 3.1e-13 Acylcarnitine levels; CRC cis rs7618915 0.547 rs13085331 chr3:52627486 G/C cg08222913 chr3:52553049 STAB1 -0.34 -6.21 -0.32 1.64e-9 Bipolar disorder; CRC cis rs681343 1.000 rs516316 chr19:49206145 C/G cg01656853 chr19:49199172 FUT2 0.23 5.79 0.3 1.65e-8 Lung adenocarcinoma;Primary sclerosing cholangitis;Childhood ear infection; CRC cis rs9649465 0.967 rs11765790 chr7:123293152 A/C cg03229431 chr7:123269106 ASB15 -0.38 -5.77 -0.3 1.82e-8 Migraine; CRC cis rs6456156 0.846 rs7749827 chr6:167515624 C/T cg05540913 chr6:167530185 CCR6 -0.34 -5.85 -0.31 1.2e-8 Primary biliary cholangitis; CRC trans rs116095464 0.558 rs28635197 chr5:279071 T/C cg00938859 chr5:1591904 SDHAP3 0.7 7.53 0.38 4.95e-13 Breast cancer; CRC trans rs4650994 0.525 rs4076563 chr1:178516901 C/T cg05059571 chr16:84539110 KIAA1609 -0.64 -8.87 -0.44 4.81e-17 HDL cholesterol levels;HDL cholesterol; CRC cis rs4750440 0.585 rs35982189 chr10:14029875 T/C cg00551146 chr10:14014579 FRMD4A 0.44 6.92 0.36 2.32e-11 Adiponectin levels; CRC cis rs17767392 0.846 rs17767398 chr14:71770485 C/G cg13720639 chr14:72061746 SIPA1L1 -0.43 -5.91 -0.31 8.35e-9 Mitral valve prolapse; CRC cis rs10924970 0.967 rs2185021 chr1:235452744 G/A cg26050004 chr1:235667680 B3GALNT2 0.39 5.77 0.3 1.87e-8 Asthma; CRC cis rs7772486 0.754 rs6570703 chr6:145957052 C/T cg05347473 chr6:146136440 FBXO30 0.37 5.72 0.3 2.45e-8 Lobe attachment (rater-scored or self-reported); CRC cis rs7677751 0.806 rs7673984 chr4:55088761 C/T cg13615338 chr4:55094005 PDGFRA 0.41 5.83 0.31 1.29e-8 Corneal astigmatism; CRC cis rs11627756 0.957 rs11846451 chr14:103131723 T/C cg12046867 chr14:103022105 NA 0.44 6.05 0.32 3.97e-9 Mean platelet volume; CRC cis rs889312 0.500 rs832577 chr5:56163787 G/A cg12311346 chr5:56204834 C5orf35 -0.46 -6.99 -0.36 1.52e-11 Breast cancer;Breast cancer (early onset); CRC cis rs10504229 0.683 rs2318147 chr8:58114931 C/T cg20607798 chr8:58055168 NA 0.5 5.9 0.31 9.16e-9 Developmental language disorder (linguistic errors); CRC trans rs1455244 0.700 rs7229302 chr18:11508904 G/T cg10439911 chr2:85766251 MAT2A 0.4 6.15 0.32 2.2e-9 Schizophrenia; CRC cis rs28830936 1.000 rs11629485 chr15:41904569 C/T cg17847044 chr15:42102381 MAPKBP1 -0.29 -6.1 -0.32 2.9e-9 Diastolic blood pressure; CRC cis rs11098499 0.754 rs9999724 chr4:120239944 C/T cg09307838 chr4:120376055 NA 0.62 9.75 0.47 6.85e-20 Corneal astigmatism; CRC cis rs911119 0.954 rs35966482 chr20:23620716 G/T cg16589663 chr20:23618590 CST3 0.62 8.01 0.4 2.01e-14 Chronic kidney disease; CRC trans rs4263408 0.934 rs9683743 chr4:39703194 A/C cg18585273 chr17:66197086 NA -0.49 -7.4 -0.38 1.11e-12 Plasma amyloid beta peptide concentrations (ABx-40); CRC cis rs8177253 0.965 rs8177245 chr3:133479230 A/G cg01448562 chr3:133502909 NA -0.53 -9.1 -0.45 8.68e-18 Iron status biomarkers; CRC cis rs10504229 0.728 rs72650868 chr8:58155568 G/C cg24829409 chr8:58192753 C8orf71 -0.58 -7.96 -0.4 2.86e-14 Developmental language disorder (linguistic errors); CRC cis rs7914558 0.966 rs4917997 chr10:104945213 A/G cg04362960 chr10:104952993 NT5C2 0.59 8.59 0.43 3.53e-16 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs2032447 0.839 rs199751 chr6:26015583 T/C cg12310025 chr6:25882481 NA -0.55 -7.68 -0.39 1.88e-13 Intelligence (multi-trait analysis); CRC cis rs875971 0.862 rs11765791 chr7:65936574 A/G cg12463550 chr7:65579703 CRCP 0.46 6.24 0.33 1.38e-9 Aortic root size; CRC cis rs875971 1.000 rs35149210 chr7:65929925 T/C cg00343986 chr7:65444356 GUSB 0.43 6.29 0.33 1.03e-9 Aortic root size; CRC cis rs67311347 1.000 rs12638199 chr3:40475285 A/G cg09455208 chr3:40491958 NA 0.43 8.68 0.43 1.83e-16 Renal cell carcinoma; CRC trans rs1814175 0.817 rs1851858 chr11:49855638 G/A cg15704280 chr7:45808275 SEPT13 -1.0 -20.06 -0.74 5.05e-59 Height; CRC cis rs4654899 0.931 rs4654887 chr1:21234923 A/G cg02927042 chr1:21476669 EIF4G3 0.46 7.37 0.38 1.41e-12 Superior frontal gyrus grey matter volume; CRC cis rs7618915 0.547 rs62253700 chr3:52625019 T/A cg11645453 chr3:52864694 ITIH4 0.35 6.05 0.32 3.99e-9 Bipolar disorder; CRC cis rs1448094 0.547 rs7954472 chr12:86166258 T/C cg25456477 chr12:86230367 RASSF9 0.38 6.3 0.33 9.43e-10 Major depressive disorder; CRC cis rs8078723 1.000 rs709592 chr17:38175553 C/T cg17467752 chr17:38218738 THRA 0.74 12.1 0.55 3.95e-28 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); CRC cis rs6445525 1.000 rs6445525 chr3:65993104 C/G cg06109867 chr3:66002991 MAGI1 0.38 6.4 0.33 5.46e-10 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs1728785 1.000 rs4783656 chr16:68580722 C/T cg02972257 chr16:68554789 NA -0.58 -7.24 -0.37 3.21e-12 Ulcerative colitis; CRC cis rs9659323 1.000 rs12073056 chr1:119508400 C/T cg26570165 chr1:119541833 NA -0.38 -6.48 -0.34 3.44e-10 Body mass index; CRC cis rs1843834 1.000 rs1843834 chr2:225558042 A/G cg22455342 chr2:225449267 CUL3 0.48 6.29 0.33 9.83e-10 IgE levels in asthmatics (D.p. specific); CRC cis rs12983728 0.732 rs34003091 chr19:58662254 T/C cg12792011 chr19:58661915 ZNF329 0.75 8.19 0.41 5.94e-15 Cholesterol, total; CRC cis rs950169 1.000 rs1848093 chr15:84755527 G/C cg24253500 chr15:84953950 NA 0.38 6.44 0.33 4.32e-10 Schizophrenia; CRC cis rs11212617 1.000 rs652311 chr11:108240069 G/A cg12106634 chr11:108092400 ATM;NPAT 0.44 6.64 0.34 1.27e-10 Response to metformin in type 2 diabetes (glycemic); CRC cis rs904251 0.772 rs2776906 chr6:37431757 A/G cg25019722 chr6:37503610 NA -0.41 -6.91 -0.36 2.57e-11 Cognitive performance; CRC cis rs66573146 0.901 rs55659111 chr4:7012338 G/T cg00086871 chr4:6988644 TBC1D14 0.95 5.87 0.31 1.06e-8 Granulocyte percentage of myeloid white cells; CRC cis rs896854 0.818 rs896855 chr8:95959808 A/G cg13393036 chr8:95962371 TP53INP1 -0.52 -8.92 -0.44 3.3e-17 Type 2 diabetes; CRC cis rs2179367 0.920 rs560051 chr6:149666977 G/A cg11245181 chr6:149772854 ZC3H12D -0.42 -6.51 -0.34 2.89e-10 Dupuytren's disease; CRC cis rs2836950 0.501 rs2836985 chr21:40701169 A/G cg11890956 chr21:40555474 PSMG1 -0.6 -8.77 -0.44 9.96e-17 Menarche (age at onset); CRC cis rs6445967 1.000 rs62259324 chr3:58291107 T/C cg23715586 chr3:58305044 RPP14 0.35 5.84 0.31 1.24e-8 Platelet count; CRC cis rs17270561 0.583 rs6937800 chr6:25765943 A/G cg16482183 chr6:26056742 HIST1H1C 0.71 9.0 0.44 1.79e-17 Iron status biomarkers; CRC cis rs7726839 0.540 rs3749618 chr5:602650 A/G cg14541582 chr5:601475 NA -0.36 -7.3 -0.37 2.24e-12 Obesity-related traits; CRC cis rs6840360 0.901 rs1443094 chr4:152456724 C/T cg09659197 chr4:152720779 NA 0.39 7.99 0.4 2.29e-14 Intelligence (multi-trait analysis); CRC cis rs11190604 1.000 rs10883508 chr10:102294413 G/A cg07080220 chr10:102295463 HIF1AN 0.49 5.97 0.31 5.99e-9 Palmitoleic acid (16:1n-7) levels; CRC cis rs4969178 0.965 rs11077362 chr17:76397219 A/T cg05887092 chr17:76393375 PGS1 0.55 10.0 0.48 1.01e-20 HDL cholesterol levels; CRC cis rs2108622 0.683 rs111388185 chr19:15977414 T/C cg13772218 chr19:15982569 NA 0.47 6.59 0.34 1.74e-10 Circulating phylloquinone levels;Vitamin E levels;Acenocoumarol maintenance dosage;Response to Vitamin E supplementation;Metabolite levels;Warfarin maintenance dose; CRC cis rs9389248 0.708 rs7750574 chr6:135350932 G/C cg22676075 chr6:135203613 NA 0.59 8.97 0.44 2.31e-17 High light scatter reticulocyte percentage of red cells; CRC cis rs950027 0.596 rs2467853 chr15:45698793 T/G cg21132104 chr15:45694354 SPATA5L1 0.4 5.66 0.3 3.3e-8 Response to fenofibrate (adiponectin levels); CRC cis rs897984 0.542 rs7199949 chr16:31096164 G/C cg00531865 chr16:30841666 NA -0.42 -6.09 -0.32 3.15e-9 Dementia with Lewy bodies; CRC cis rs1403694 0.695 rs11927941 chr3:186433046 A/G cg04611788 chr3:186434169 KNG1 -0.6 -8.83 -0.44 6.23e-17 Blood protein levels; CRC cis rs9359856 0.517 rs11962350 chr6:90592406 G/A cg13799429 chr6:90582589 CASP8AP2 -0.73 -7.71 -0.39 1.48e-13 Bipolar disorder; CRC cis rs4689592 0.546 rs10937784 chr4:7060935 G/C cg19539972 chr4:7069911 GRPEL1 0.75 9.88 0.48 2.48e-20 Monocyte percentage of white cells; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg02737830 chr12:64616354 C12orf66 0.42 5.97 0.31 6.28e-9 Response to antipsychotic treatment; CRC cis rs2070677 0.935 rs12255182 chr10:135404096 G/A cg20169779 chr10:135381914 SYCE1 -0.99 -15.33 -0.65 2.07e-40 Gout; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg17289057 chr17:74473006 RHBDF2 0.39 6.29 0.33 1.02e-9 Myopia (pathological); CRC cis rs7666738 0.830 rs10034330 chr4:99064849 G/A cg05340658 chr4:99064831 C4orf37 0.6 9.38 0.46 1.1e-18 Colonoscopy-negative controls vs population controls; CRC cis rs2882667 0.654 rs1095374 chr5:138095206 A/G cg09476006 chr5:138032270 NA -0.58 -10.46 -0.5 2.61e-22 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs6662572 1.000 rs28433203 chr1:46196813 G/T cg08644498 chr1:46502608 NA 0.46 6.64 0.34 1.32e-10 Blood protein levels; CRC trans rs6561151 1.000 rs6561151 chr13:44484706 G/A cg17145862 chr1:211918768 LPGAT1 0.5 7.15 0.37 5.78e-12 Crohn's disease; CRC cis rs9640161 0.789 rs13223702 chr7:150058968 G/A cg13722127 chr7:150037890 RARRES2 0.39 5.65 0.3 3.43e-8 Blood protein levels;Circulating chemerin levels; CRC cis rs6940638 0.688 rs9393791 chr6:27132529 C/G cg12292205 chr6:26970375 C6orf41 -0.5 -6.68 -0.35 1e-10 Intelligence (multi-trait analysis); CRC cis rs3749237 0.964 rs11714957 chr3:49776178 C/T cg24308560 chr3:49941425 MST1R -0.42 -6.08 -0.32 3.34e-9 Resting heart rate; CRC cis rs9911578 0.842 rs12450766 chr17:56832965 G/C cg05425664 chr17:57184151 TRIM37 0.44 6.29 0.33 9.93e-10 Intelligence (multi-trait analysis); CRC cis rs13256369 1.000 rs12547721 chr8:8570671 C/T cg00074818 chr8:8560427 CLDN23 0.4 7.34 0.37 1.74e-12 Obesity-related traits; CRC cis rs10256972 0.552 rs2949195 chr7:1202705 G/A cg04025307 chr7:1156635 C7orf50 0.67 10.71 0.51 3.79e-23 Longevity;Endometriosis; CRC cis rs9354352 0.935 rs9354354 chr6:66699333 A/G cg07460842 chr6:66804631 NA -0.62 -9.16 -0.45 5.5e-18 Initial pursuit acceleration in psychotic disorders; CRC cis rs1008375 1.000 rs10939748 chr4:17691230 T/C cg16339924 chr4:17578868 LAP3 0.46 6.11 0.32 2.88e-9 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs116095464 0.558 rs7730700 chr5:264713 G/A cg22857025 chr5:266934 NA -1.25 -16.78 -0.68 4.42e-46 Breast cancer; CRC cis rs7647973 0.560 rs77473999 chr3:49777660 T/C cg03060546 chr3:49711283 APEH -0.62 -6.97 -0.36 1.78e-11 Menarche (age at onset); CRC cis rs12618769 0.652 rs4851144 chr2:99220707 T/C cg18455616 chr2:99124870 INPP4A 0.35 5.92 0.31 8.22e-9 Bipolar disorder; CRC cis rs7762018 0.769 rs4716385 chr6:170127608 G/T cg24289452 chr6:170231220 NA -0.67 -6.79 -0.35 5.28e-11 Thiazide-induced adverse metabolic effects in hypertensive patients; CRC cis rs11628318 0.853 rs8003309 chr14:103050143 C/G cg08075719 chr14:103021372 NA -0.72 -9.49 -0.46 4.8e-19 Platelet count; CRC cis rs9322193 0.926 rs9689036 chr6:150101699 T/C cg05861140 chr6:150128134 PCMT1 -0.4 -6.58 -0.34 1.82e-10 Lung cancer; CRC cis rs9308731 0.623 rs2241841 chr2:111879467 G/A cg18646521 chr2:111875858 NA 0.36 5.63 0.3 3.96e-8 Chronic lymphocytic leukemia; CRC cis rs1448094 0.817 rs10779220 chr12:86323543 T/A cg25456477 chr12:86230367 RASSF9 0.34 5.74 0.3 2.14e-8 Major depressive disorder; CRC cis rs4750440 0.702 rs11258774 chr10:14029701 G/A cg00551146 chr10:14014579 FRMD4A 0.36 5.85 0.31 1.19e-8 Adiponectin levels; CRC cis rs875971 0.790 rs10257911 chr7:65743770 A/G cg18876405 chr7:65276391 NA -0.54 -8.56 -0.43 4.3e-16 Aortic root size; CRC cis rs739401 0.588 rs10219272 chr11:3020789 G/A cg25174290 chr11:3078921 CARS 0.48 7.48 0.38 7.02e-13 Longevity; CRC cis rs7918232 0.882 rs788211 chr10:27479070 C/T cg14240646 chr10:27532245 ACBD5 0.85 9.29 0.46 2.12e-18 Breast cancer; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg05995172 chr11:57434667 ZDHHC5 0.46 7.19 0.37 4.51e-12 Liver disease severity in Alagille syndrome; CRC cis rs10504229 0.728 rs72650860 chr8:58153111 A/G cg24829409 chr8:58192753 C8orf71 -0.58 -7.96 -0.4 2.86e-14 Developmental language disorder (linguistic errors); CRC cis rs6582630 0.519 rs9738104 chr12:38338459 A/C cg26384229 chr12:38710491 ALG10B 0.68 9.05 0.45 1.25e-17 Drug-induced liver injury (flucloxacillin); CRC cis rs4733781 0.509 rs12550365 chr8:131136046 A/T cg21674704 chr8:131455249 NA -0.37 -6.04 -0.32 4.27e-9 Tuberculosis; CRC cis rs4555082 0.834 rs2816631 chr14:105739477 G/A cg13114125 chr14:105738426 BRF1 -0.84 -12.34 -0.56 5.21e-29 Mean platelet volume;Platelet distribution width; CRC cis rs10504229 0.683 rs7000349 chr8:58114569 C/A cg02725872 chr8:58115012 NA -0.65 -11.61 -0.54 2.34e-26 Developmental language disorder (linguistic errors); CRC cis rs995000 0.899 rs4495740 chr1:63124465 T/G cg19896129 chr1:63156450 NA 0.39 5.61 0.3 4.35e-8 Triglyceride levels; CRC cis rs12900463 0.813 rs306198 chr15:85405369 C/T cg11189052 chr15:85197271 WDR73 -0.48 -6.64 -0.34 1.3e-10 Adverse response to chemotherapy (neutropenia/leucopenia) (gemcitabine); CRC cis rs2404602 0.967 rs12148805 chr15:76800659 G/A cg03037974 chr15:76606532 NA 0.58 9.6 0.47 2.16e-19 Blood metabolite levels; CRC cis rs62012628 0.527 rs12438008 chr15:79084680 C/T cg22753661 chr15:79092743 ADAMTS7 -0.46 -6.61 -0.34 1.57e-10 Diastolic blood pressure; CRC trans rs75246769 1.000 rs74441628 chr7:145588168 A/G cg14916917 chr5:81574294 RPS23 0.8 5.97 0.31 6.06e-9 Facial morphology (factor 10, width of nasal floor); CRC cis rs7098414 0.511 rs7899545 chr10:82150635 G/C cg00277334 chr10:82204260 NA -0.47 -7.58 -0.39 3.48e-13 Post bronchodilator FEV1; CRC cis rs7618915 0.501 rs2159644 chr3:52774530 C/T cg05573699 chr3:52720067 GNL3;PBRM1 -0.47 -6.83 -0.35 3.99e-11 Bipolar disorder; CRC cis rs3820068 0.580 rs34426856 chr1:16006315 C/T cg13390004 chr1:15929781 NA 0.5 6.98 0.36 1.61e-11 Systolic blood pressure; CRC cis rs10540 1.000 rs35231079 chr11:515224 G/A cg03576123 chr11:487126 PTDSS2 -1.04 -10.78 -0.51 2.09e-23 Body mass index; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg07083384 chr2:75836410 NA 0.41 5.99 0.31 5.54e-9 Intelligence (multi-trait analysis); CRC cis rs1539053 0.932 rs7544337 chr1:58108645 T/C cg20292791 chr1:58089357 DAB1 -0.32 -5.67 -0.3 3.13e-8 Plasma omega-6 polyunsaturated fatty acid levels (arachidonic acid); CRC cis rs7712401 0.791 rs4836244 chr5:122116232 A/G cg18764291 chr5:122110994 SNX2 0.39 6.35 0.33 7.19e-10 Mean platelet volume; CRC cis rs2880765 0.743 rs12906308 chr15:86008059 C/T cg17133734 chr15:86042851 AKAP13 -0.4 -6.34 -0.33 7.51e-10 Coronary artery disease; CRC cis rs2380220 0.576 rs4498363 chr6:96042338 A/C cg07718321 chr6:96025334 MANEA 0.57 7.18 0.37 4.73e-12 Behavioural disinhibition (generation interaction); CRC cis rs2070677 0.877 rs8192777 chr10:135350871 G/T cg20169779 chr10:135381914 SYCE1 0.79 11.32 0.53 2.59e-25 Gout; CRC cis rs738322 1.000 rs738322 chr22:38569006 A/G cg17652424 chr22:38574118 PLA2G6 -0.22 -6.82 -0.35 4.44e-11 Cutaneous nevi; CRC cis rs4713118 0.662 rs13218430 chr6:28029837 T/C cg06470822 chr6:28175283 NA 0.95 13.56 0.6 1.43e-33 Parkinson's disease; CRC cis rs7827545 1.000 rs1372662 chr8:135567046 C/G cg17885191 chr8:135476712 NA 0.51 7.22 0.37 3.7e-12 Hypertension (SNP x SNP interaction); CRC cis rs9549260 0.755 rs2721071 chr13:41144507 G/A cg21288729 chr13:41239152 FOXO1 0.4 6.15 0.32 2.2e-9 Red blood cell count; CRC cis rs6570726 0.791 rs7755253 chr6:145858893 C/G cg05347473 chr6:146136440 FBXO30 0.39 5.95 0.31 6.94e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs6901250 0.851 rs339361 chr6:117162515 C/T cg12892004 chr6:117198278 RFX6 0.44 6.85 0.35 3.66e-11 C-reactive protein levels; CRC cis rs904251 0.523 rs12202055 chr6:37486080 A/T cg01843034 chr6:37503916 NA -0.39 -6.98 -0.36 1.68e-11 Cognitive performance; CRC cis rs2228479 1.000 rs12596492 chr16:89957169 T/G cg06656553 chr16:89960601 TCF25 -0.69 -6.06 -0.32 3.75e-9 Skin colour saturation; CRC trans rs7615952 0.932 rs6438948 chr3:125650045 A/T cg16558177 chr4:4109446 NA 0.45 6.03 0.32 4.49e-9 Blood pressure (smoking interaction); CRC cis rs10504229 0.906 rs7006539 chr8:58178799 A/T cg22535103 chr8:58192502 C8orf71 -0.81 -11.8 -0.55 4.73e-27 Developmental language disorder (linguistic errors); CRC cis rs11628318 0.614 rs7155489 chr14:103123119 C/T cg23071808 chr14:103021642 NA 0.56 5.98 0.31 5.91e-9 Platelet count; CRC cis rs728616 0.867 rs41297151 chr10:81807167 A/T cg05935833 chr10:81318306 SFTPA2 -0.57 -6.93 -0.36 2.27e-11 Chronic obstructive pulmonary disease-related biomarkers; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg21490755 chr8:66754279 PDE7A 0.41 6.16 0.32 2.17e-9 Anxiety disorder; CRC cis rs7121446 0.521 rs4084215 chr11:121867511 T/C cg13820391 chr11:121835505 NA 0.33 5.97 0.31 6.2e-9 Cardiovascular risk factors (age interaction); CRC cis rs6502050 0.805 rs7406137 chr17:80084465 T/C cg22110888 chr17:80059540 CCDC57 -0.42 -6.47 -0.34 3.6e-10 Life satisfaction; CRC cis rs3741151 0.773 rs79994237 chr11:73147974 T/C cg17517138 chr11:73019481 ARHGEF17 1.04 8.62 0.43 2.85e-16 GIP levels in response to oral glucose tolerance test (120 minutes); CRC cis rs7208859 0.623 rs9893422 chr17:29111715 A/G cg01831904 chr17:28903510 LRRC37B2 -0.63 -6.45 -0.33 4.07e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs853679 0.517 rs11552219 chr6:28126834 C/T cg21251018 chr6:28226885 NKAPL 0.48 6.17 0.32 2.02e-9 Depression; CRC cis rs9311676 0.656 rs4681682 chr3:58337833 A/G cg06643156 chr3:58380774 PXK -0.44 -6.79 -0.35 5.2e-11 Systemic lupus erythematosus; CRC cis rs7617480 0.585 rs7373072 chr3:48960017 T/A cg20833759 chr3:49053208 WDR6;DALRD3 0.67 10.97 0.52 4.37e-24 Subjective well-being (multi-trait analysis);Menarche (age at onset); CRC trans rs2228479 0.850 rs11641552 chr16:89838700 C/A cg24644049 chr4:85504048 CDS1 0.9 7.57 0.39 3.72e-13 Skin colour saturation; CRC cis rs4888262 0.526 rs13330282 chr16:74572373 C/T cg01733217 chr16:74700730 RFWD3 0.75 11.36 0.53 1.81e-25 Testicular germ cell tumor; CRC cis rs8114671 0.662 rs6088664 chr20:33551100 G/A cg07148914 chr20:33460835 GGT7 0.38 6.12 0.32 2.61e-9 Height; CRC cis rs9828933 0.752 rs17069507 chr3:63924956 A/G cg16258503 chr3:63850278 ATXN7;THOC7 -0.69 -5.97 -0.31 5.99e-9 Type 2 diabetes; CRC cis rs7666738 0.830 rs13122054 chr4:98972974 G/A cg17366294 chr4:99064904 C4orf37 0.43 7.32 0.37 1.88e-12 Colonoscopy-negative controls vs population controls; CRC cis rs2239547 0.563 rs6797399 chr3:52905917 G/A cg10802521 chr3:52805072 NEK4 -0.47 -6.38 -0.33 5.99e-10 Schizophrenia; CRC cis rs736408 0.509 rs13083798 chr3:52649748 A/G cg18404041 chr3:52824283 ITIH1 -0.29 -5.99 -0.31 5.59e-9 Bipolar disorder; CRC cis rs10504229 0.728 rs72650868 chr8:58155568 G/C cg11062466 chr8:58055876 NA 0.45 6.11 0.32 2.74e-9 Developmental language disorder (linguistic errors); CRC cis rs7666738 0.791 rs7658177 chr4:99035192 T/C cg05340658 chr4:99064831 C4orf37 0.61 9.43 0.46 7.65e-19 Colonoscopy-negative controls vs population controls; CRC cis rs35110281 0.837 rs2838336 chr21:45071741 A/G cg04455712 chr21:45112962 RRP1B -0.4 -7.68 -0.39 1.88e-13 Mean corpuscular volume; CRC cis rs992157 0.835 rs12987219 chr2:219144149 G/A cg13835894 chr2:219148914 PNKD;TMBIM1 -0.35 -6.81 -0.35 4.66e-11 Colorectal cancer; CRC cis rs9818758 0.505 rs11716159 chr3:49631585 G/A cg07636037 chr3:49044803 WDR6 -0.76 -5.68 -0.3 3.02e-8 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; CRC cis rs769267 0.965 rs7254230 chr19:19434350 C/T cg02546618 chr19:19431379 KIAA0892;SF4 -0.47 -6.65 -0.34 1.24e-10 Tonsillectomy; CRC cis rs7546094 1.000 rs7546094 chr1:113154400 C/T cg22162597 chr1:113214053 CAPZA1 0.44 6.03 0.32 4.39e-9 Platelet distribution width; CRC trans rs1455244 0.700 rs7229302 chr18:11508904 G/T cg08228715 chr17:79895357 PYCR1 0.39 6.11 0.32 2.85e-9 Schizophrenia; CRC cis rs853679 0.760 rs11967137 chr6:28199764 A/G cg25164649 chr6:28176230 NA 0.59 6.14 0.32 2.33e-9 Depression; CRC cis rs1519814 1.000 rs4588897 chr8:121139142 A/G cg22335954 chr8:121166405 COL14A1 -0.56 -6.44 -0.33 4.13e-10 Breast cancer; CRC cis rs977987 0.806 rs4888388 chr16:75394148 G/A cg03315344 chr16:75512273 CHST6 0.54 9.07 0.45 1.13e-17 Dupuytren's disease; CRC cis rs216303 0.554 rs216320 chr12:6143356 T/C cg19878637 chr12:6148451 VWF -0.64 -6.96 -0.36 1.87e-11 Low vWF levels; CRC cis rs7849270 0.959 rs7039031 chr9:131899395 A/G cg13538475 chr9:131942899 NA -0.32 -6.38 -0.33 6.13e-10 Blood metabolite ratios; CRC cis rs10504229 0.728 rs72650861 chr8:58153273 T/C cg05313129 chr8:58192883 C8orf71 -0.47 -6.18 -0.32 1.94e-9 Developmental language disorder (linguistic errors); CRC cis rs9549367 0.756 rs9549702 chr13:113881944 T/G cg00898013 chr13:113819073 PROZ -0.42 -6.26 -0.33 1.17e-9 Platelet distribution width; CRC cis rs6964587 0.869 rs2013334 chr7:91549657 G/A cg17063962 chr7:91808500 NA -0.76 -13.0 -0.58 1.74e-31 Breast cancer; CRC cis rs8180040 0.701 rs12491473 chr3:46989904 G/A cg27129171 chr3:47204927 SETD2 -0.72 -11.4 -0.53 1.32e-25 Colorectal cancer; CRC cis rs7617773 1.000 rs12496784 chr3:48186267 C/T cg11946769 chr3:48343235 NME6 -0.47 -6.58 -0.34 1.81e-10 Coronary artery disease; CRC cis rs9399137 0.507 rs11759077 chr6:135381351 A/G cg22676075 chr6:135203613 NA 0.59 8.83 0.44 6.44e-17 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; CRC cis rs651907 0.535 rs13065944 chr3:101473088 G/A cg11279151 chr3:101281821 RG9MTD1 -0.54 -7.4 -0.38 1.12e-12 Colorectal cancer; CRC cis rs9522267 0.535 rs4773393 chr13:112229755 A/G cg10483660 chr13:112241077 NA -0.47 -8.74 -0.43 1.17e-16 Hepatitis; CRC cis rs4523957 0.928 rs177567 chr17:2197637 A/G cg16513277 chr17:2031491 SMG6 -0.54 -9.11 -0.45 8.28e-18 Autism spectrum disorder or schizophrenia;Schizophrenia; CRC cis rs873946 0.648 rs12771651 chr10:134554482 C/A cg26818010 chr10:134567672 INPP5A -0.69 -8.86 -0.44 5.25e-17 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CRC cis rs72730918 0.564 rs956171 chr15:51837138 C/T cg14296394 chr15:51910925 DMXL2 -0.45 -5.99 -0.31 5.56e-9 Intelligence (multi-trait analysis); CRC cis rs546131 0.928 rs558967 chr11:34827168 T/A cg06937548 chr11:34938143 PDHX;APIP 0.38 5.68 0.3 2.94e-8 Lung disease severity in cystic fibrosis; CRC cis rs10256972 0.524 rs6945202 chr7:1116558 T/C cg03188948 chr7:1209495 NA 0.44 6.39 0.33 5.59e-10 Longevity;Endometriosis; CRC cis rs6570726 0.755 rs2092297 chr6:145893765 A/G cg05347473 chr6:146136440 FBXO30 0.38 5.85 0.31 1.18e-8 Lobe attachment (rater-scored or self-reported); CRC cis rs12325245 0.536 rs34161389 chr16:58622604 G/A cg01472538 chr16:58549086 SETD6 1.12 7.38 0.38 1.28e-12 Schizophrenia; CRC cis rs1862618 0.853 rs1559282 chr5:56099375 T/A cg12311346 chr5:56204834 C5orf35 -0.73 -9.48 -0.46 5.09e-19 Initial pursuit acceleration; CRC cis rs7786808 0.544 rs6971888 chr7:158193835 G/A cg01191920 chr7:158217561 PTPRN2 0.6 9.73 0.47 7.71e-20 Obesity-related traits; CRC cis rs8014671 0.519 rs12884918 chr14:70890778 T/C cg25576086 chr14:70833871 SYNJ2BP -0.35 -5.88 -0.31 9.99e-9 Prostate cancer; CRC cis rs11195062 0.766 rs1891375 chr10:112001009 A/G cg00817464 chr10:111662876 XPNPEP1 -0.36 -5.62 -0.3 4.04e-8 Multiple myeloma; CRC cis rs2949837 0.581 rs924140 chr7:45963114 C/T cg21268650 chr7:45961089 IGFBP3 0.38 6.52 0.34 2.64e-10 Sitting height ratio; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg02855924 chr3:50402563 CACNA2D2 0.43 6.02 0.31 4.54e-9 Response to antipsychotic treatment; CRC cis rs12913538 0.862 rs7162434 chr15:62888070 A/G cg09983546 chr15:62884068 NA 0.54 8.62 0.43 2.82e-16 Sleep depth; CRC cis rs4698036 0.586 rs7672759 chr4:10285015 G/A cg00071950 chr4:10020882 SLC2A9 0.41 6.54 0.34 2.39e-10 Cardiovascular disease risk factors; CRC cis rs801193 1.000 rs2659889 chr7:66217112 A/G cg11764359 chr7:65958608 NA 0.54 8.31 0.42 2.48e-15 Aortic root size; CRC cis rs10985070 0.507 rs12551347 chr9:123936594 G/A cg09419670 chr9:123605666 PSMD5;LOC253039 0.37 5.62 0.3 4.05e-8 Rheumatoid arthritis; CRC cis rs7615952 0.641 rs6805074 chr3:125772274 T/A cg15145296 chr3:125709740 NA -0.57 -6.75 -0.35 6.67e-11 Blood pressure (smoking interaction); CRC cis rs4713118 0.869 rs9295742 chr6:27702832 G/A cg15845792 chr6:28175446 NA 0.65 9.11 0.45 7.98e-18 Parkinson's disease; CRC cis rs4969178 0.622 rs4129767 chr17:76403984 G/A cg02319466 chr17:76381040 PGS1 0.37 5.87 0.31 1.06e-8 HDL cholesterol levels; CRC cis rs9399137 0.507 rs7771310 chr6:135272535 G/A cg22676075 chr6:135203613 NA 0.61 8.97 0.44 2.38e-17 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; CRC cis rs7959452 0.530 rs12811632 chr12:69755003 G/A cg20891283 chr12:69753455 YEATS4 0.86 15.39 0.65 1.18e-40 Blood protein levels; CRC trans rs73162807 0.655 rs114655191 chr3:146439760 G/A cg26896787 chr1:228603707 TRIM17 -0.59 -5.99 -0.31 5.61e-9 Platelet-derived growth factor BB levels; CRC cis rs1552244 0.935 rs35586456 chr3:10116938 A/G cg10729496 chr3:10149963 C3orf24 0.5 6.78 0.35 5.69e-11 Alzheimer's disease; CRC cis rs10927875 0.631 rs945418 chr1:16344730 T/C cg10494257 chr1:16342123 HSPB7 0.45 5.95 0.31 6.71e-9 Dilated cardiomyopathy; CRC cis rs2108622 0.727 rs12609468 chr19:15977814 A/G cg13772218 chr19:15982569 NA 0.48 6.66 0.34 1.18e-10 Circulating phylloquinone levels;Vitamin E levels;Acenocoumarol maintenance dosage;Response to Vitamin E supplementation;Metabolite levels;Warfarin maintenance dose; CRC cis rs4819052 1.000 rs2838830 chr21:46664227 T/G cg11663144 chr21:46675770 NA -0.79 -11.74 -0.54 8.11e-27 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs644148 0.679 rs2204119 chr19:44970975 T/C cg15540054 chr19:45004280 ZNF180 -0.55 -7.01 -0.36 1.33e-11 Personality dimensions; CRC cis rs4843747 0.671 rs8062855 chr16:88106941 T/C cg03395651 chr16:88107091 BANP 0.6 8.16 0.41 7.06e-15 Menopause (age at onset); CRC cis rs2239547 0.618 rs4687663 chr3:52870618 T/A cg15147215 chr3:52552868 STAB1 -0.43 -6.05 -0.32 3.92e-9 Schizophrenia; CRC cis rs6963495 0.818 rs6956249 chr7:105149743 A/T cg02135003 chr7:105160482 PUS7 -0.89 -12.26 -0.56 9.87e-29 Bipolar disorder (body mass index interaction); CRC cis rs9486715 0.830 rs1475748 chr6:97034143 T/C cg18709589 chr6:96969512 KIAA0776 -0.5 -7.55 -0.38 4.23e-13 Headache; CRC cis rs3018066 0.831 rs7668276 chr4:107156365 C/G cg01869342 chr4:106983673 TBCK -0.36 -5.67 -0.3 3.05e-8 Cancer; CRC cis rs2077654 0.556 rs4148624 chr11:17444024 A/G cg25308976 chr11:17434268 ABCC8 0.52 5.96 0.31 6.61e-9 Gout; CRC cis rs11077998 0.967 rs4614761 chr17:80505809 C/T cg10255544 chr17:80519551 FOXK2 0.38 6.06 0.32 3.79e-9 Reticulocyte fraction of red cells; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg11617147 chr7:105517689 ATXN7L1 0.4 6.64 0.34 1.26e-10 Intelligence (multi-trait analysis); CRC cis rs7258465 1.000 rs8105994 chr19:18593553 A/G cg10790698 chr19:18539756 SSBP4 -0.4 -7.27 -0.37 2.56e-12 Breast cancer; CRC trans rs3932549 1 rs3932549 chr9:97073588 A/C cg05679027 chr9:99775184 HIATL2 0.4 6.07 0.32 3.5e-9 Body mass index; CRC cis rs1801251 1.000 rs4973053 chr2:233670099 G/A cg25237894 chr2:233734115 C2orf82 -0.54 -8.82 -0.44 7.06e-17 Coronary artery disease; CRC cis rs651907 0.535 rs11919389 chr3:101424458 T/C cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.58 7.71 0.39 1.49e-13 Colorectal cancer; CRC cis rs11971779 0.618 rs9640925 chr7:139085288 G/A cg07862535 chr7:139043722 LUC7L2 0.57 7.35 0.38 1.61e-12 Diisocyanate-induced asthma; CRC cis rs853679 0.517 rs4713146 chr6:28111536 A/T cg15845792 chr6:28175446 NA 1.04 13.89 0.61 7.67e-35 Depression; CRC cis rs8062405 1.000 rs62036621 chr16:28833299 C/A cg08761264 chr16:28874980 SH2B1 -0.42 -5.66 -0.3 3.26e-8 Cognitive ability (multi-trait analysis);Cognitive ability; CRC cis rs10781543 0.839 rs4379550 chr9:139376426 C/T cg14019695 chr9:139328340 INPP5E -0.4 -5.93 -0.31 7.5e-9 Monocyte percentage of white cells; CRC cis rs60871478 0.947 rs62432239 chr7:794576 C/T cg05535760 chr7:792225 HEATR2 0.77 10.16 0.49 2.76e-21 Cerebrospinal P-tau181p levels; CRC cis rs10751667 0.666 rs4074234 chr11:977715 C/G cg23136738 chr11:925521 AP2A2 -0.42 -7.09 -0.36 8.19e-12 Alzheimer's disease (late onset); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg05947596 chr6:99969103 NA 0.46 6.63 0.34 1.35e-10 Intelligence (multi-trait analysis); CRC cis rs7605827 0.930 rs2890487 chr2:15594938 A/G cg19274914 chr2:15703543 NA 0.39 5.9 0.31 9.14e-9 Educational attainment (years of education); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg15039414 chr2:43454687 ZFP36L2;LOC100129726 0.38 6.12 0.32 2.6e-9 Liver disease severity in Alagille syndrome; CRC cis rs6951245 1.000 rs77868187 chr7:1093968 A/C cg07217954 chr7:1067459 C7orf50 0.55 5.71 0.3 2.48e-8 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg21159241 chr7:39662930 RALA 0.44 6.06 0.32 3.73e-9 Anxiety disorder; CRC cis rs9611565 0.694 rs5751107 chr22:41857812 A/G cg03806693 chr22:41940476 POLR3H 1.04 13.22 0.59 2.71e-32 Vitiligo; CRC cis rs55702914 1.000 rs55702914 chr2:198214396 C/G cg10820045 chr2:198174542 NA 0.34 6.08 0.32 3.36e-9 Major depression and alcohol dependence; CRC cis rs12900413 0.603 rs12907030 chr15:90301439 C/T cg24249390 chr15:90295951 MESP1 -0.61 -9.28 -0.46 2.26e-18 Coronary artery aneurysm in Kawasaki disease; CRC cis rs12580194 0.598 rs12582005 chr12:55772837 A/T cg23425280 chr12:56401806 NA 0.48 5.88 0.31 1.03e-8 Cancer; CRC cis rs780096 0.526 rs1260341 chr2:27663215 T/A cg12000995 chr2:27665139 KRTCAP3 -0.32 -6.75 -0.35 6.69e-11 Total body bone mineral density; CRC cis rs8060686 0.641 rs118035472 chr16:68242311 A/G cg08314208 chr16:67682810 RLTPR -0.54 -5.9 -0.31 8.84e-9 HDL cholesterol;Metabolic syndrome; CRC cis rs2404602 0.647 rs3812909 chr15:77176200 A/T cg23625390 chr15:77176239 SCAPER -0.88 -14.03 -0.61 2.32e-35 Blood metabolite levels; CRC cis rs11098499 0.863 rs9997631 chr4:120469995 C/G cg09307838 chr4:120376055 NA 0.67 10.31 0.49 8.87e-22 Corneal astigmatism; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg17956079 chr11:73358572 PLEKHB1 0.5 7.66 0.39 2.08e-13 Response to antipsychotic treatment; CRC cis rs1499614 0.803 rs1796229 chr7:66119661 G/A cg18252515 chr7:66147081 NA -1.26 -15.13 -0.64 1.25e-39 Gout; CRC cis rs4731207 0.565 rs1552118 chr7:124628858 C/T cg23710748 chr7:124431027 NA -0.39 -6.25 -0.33 1.29e-9 Cutaneous malignant melanoma; CRC cis rs801193 1.000 rs4717310 chr7:66161007 C/T cg11764359 chr7:65958608 NA 0.55 8.58 0.43 3.76e-16 Aortic root size; CRC cis rs12540874 0.698 rs3823674 chr7:50571996 C/T cg18232548 chr7:50535776 DDC -0.51 -7.77 -0.39 9.97e-14 Systemic sclerosis; CRC cis rs9296095 0.519 rs6918046 chr6:33514567 T/A cg14003231 chr6:33640908 ITPR3 0.37 5.65 0.3 3.4e-8 Platelet count; CRC cis rs1609391 0.543 rs9859810 chr3:136629986 A/G cg15507776 chr3:136538369 TMEM22 0.34 6.19 0.32 1.83e-9 Neuroticism; CRC trans rs2243480 0.901 rs778687 chr7:65835819 G/A cg10756647 chr7:56101905 PSPH 0.78 8.01 0.4 1.97e-14 Diabetic kidney disease; CRC cis rs6502050 0.835 rs8071425 chr17:80117335 C/T cg02741985 chr17:80059408 CCDC57 -0.41 -6.66 -0.34 1.12e-10 Life satisfaction; CRC cis rs2073300 0.609 rs6137938 chr20:23389127 C/G cg12062639 chr20:23401060 NAPB 0.75 6.79 0.35 5.31e-11 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs875971 0.862 rs2420174 chr7:65645361 C/T cg11764359 chr7:65958608 NA -0.6 -9.4 -0.46 9.21e-19 Aortic root size; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg14969671 chr10:131934538 GLRX3 0.39 6.5 0.34 3e-10 Liver disease severity in Alagille syndrome; CRC cis rs172166 0.694 rs203876 chr6:28046673 T/C cg06470822 chr6:28175283 NA 0.81 12.09 0.55 4.31e-28 Cardiac Troponin-T levels; CRC cis rs8180040 0.690 rs7640397 chr3:46989828 C/T cg27129171 chr3:47204927 SETD2 0.65 10.41 0.5 4.11e-22 Colorectal cancer; CRC cis rs7412746 0.622 rs72704654 chr1:150826410 G/A cg10589385 chr1:150898437 SETDB1 0.32 6.52 0.34 2.59e-10 Melanoma; CRC trans rs703108 0.731 rs7898954 chr10:22323646 A/G cg15067376 chr9:139257843 DNLZ -0.52 -6.08 -0.32 3.4e-9 Monocyte percentage of white cells; CRC cis rs919433 0.854 rs787994 chr2:198223121 T/C cg10820045 chr2:198174542 NA 0.46 8.26 0.41 3.67e-15 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC cis rs4862750 1.000 rs4862750 chr4:187904043 C/T cg27532560 chr4:187881888 NA -0.57 -10.07 -0.49 5.72e-21 Lobe attachment (rater-scored or self-reported); CRC cis rs7703051 0.520 rs13354746 chr5:74619132 C/T cg00601450 chr5:74908170 NA 0.42 5.99 0.31 5.6e-9 LDL cholesterol;Age-related disease endophenotypes;Age-related diseases, mortality and associated endophenotypes; CRC cis rs9660992 0.710 rs1668872 chr1:205236069 G/A cg21643547 chr1:205240462 TMCC2 -0.45 -7.26 -0.37 2.84e-12 Mean corpuscular volume;Mean platelet volume; CRC cis rs4665809 1.000 rs6729080 chr2:26301282 G/A cg26119090 chr2:26468346 HADHA;HADHB -0.61 -7.91 -0.4 3.92e-14 Gut microbiome composition (summer); CRC cis rs7909074 0.966 rs4268464 chr10:45401081 T/A cg05187965 chr10:45406764 TMEM72 -0.37 -8.25 -0.41 3.97e-15 Mean corpuscular volume; CRC cis rs929354 0.709 rs1182363 chr7:157019151 A/G cg16102536 chr7:156981717 UBE3C -0.4 -6.79 -0.35 5.41e-11 Body mass index; CRC trans rs10506458 1.000 rs73127086 chr12:63415626 G/A cg22491629 chr6:157744540 C6orf35 -0.71 -8.49 -0.42 6.98e-16 Hemostatic factors and hematological phenotypes; CRC cis rs10256972 0.552 rs2949192 chr7:1203841 C/T cg03923535 chr7:1197113 ZFAND2A 0.73 11.15 0.52 1.04e-24 Longevity;Endometriosis; CRC cis rs76419734 0.510 rs4699198 chr4:106645771 G/A cg24545054 chr4:106630052 GSTCD;INTS12 0.62 7.72 0.39 1.39e-13 Post bronchodilator FEV1; CRC cis rs12348691 0.503 rs3021523 chr9:100616583 T/C cg13688889 chr9:100608707 NA -0.47 -6.05 -0.32 3.87e-9 Alopecia areata; CRC cis rs6963495 0.818 rs73192122 chr7:105171471 G/A cg13798780 chr7:105162888 PUS7 0.67 7.94 0.4 3.29e-14 Bipolar disorder (body mass index interaction); CRC cis rs2739330 0.760 rs5751761 chr22:24243736 A/G cg18538332 chr22:24372958 LOC391322 0.65 9.85 0.48 3.04e-20 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs34779708 0.658 rs4934715 chr10:35364992 G/T cg03585969 chr10:35415529 CREM 0.59 7.86 0.4 5.39e-14 Inflammatory bowel disease;Crohn's disease; CRC cis rs3771570 1.000 rs17386555 chr2:242371825 G/A cg21155796 chr2:242212141 HDLBP 0.65 7.25 0.37 3.03e-12 Prostate cancer; CRC cis rs7849270 1.000 rs10819469 chr9:131882067 G/T cg13538475 chr9:131942899 NA -0.31 -6.07 -0.32 3.48e-9 Blood metabolite ratios; CRC cis rs3126085 0.935 rs3126046 chr1:152256925 G/A cg09127314 chr1:152161683 NA -0.45 -5.86 -0.31 1.14e-8 Atopic dermatitis; CRC cis rs796364 1.000 rs281788 chr2:200783705 A/T cg23649088 chr2:200775458 C2orf69 0.55 6.01 0.31 4.96e-9 Schizophrenia; CRC cis rs2645694 0.626 rs2703140 chr4:77830057 C/G cg03477792 chr4:77819574 ANKRD56 0.46 6.62 0.34 1.49e-10 Emphysema distribution in smoking; CRC cis rs9911578 0.967 rs11079368 chr17:57086473 C/T cg12560992 chr17:57184187 TRIM37 -0.94 -17.74 -0.7 6.97e-50 Intelligence (multi-trait analysis); CRC trans rs2303319 0.504 rs62187613 chr2:162434474 T/C cg09481857 chr22:21368659 P2RX6;MGC16703 -0.65 -6.01 -0.31 4.88e-9 Cognitive function; CRC cis rs7731657 0.537 rs112876284 chr5:130293884 G/C cg08523029 chr5:130500466 HINT1 -0.49 -6.19 -0.32 1.83e-9 Fasting plasma glucose; CRC cis rs10499694 0.697 rs3779074 chr7:50612202 A/G cg14593290 chr7:50529359 DDC -0.47 -6.59 -0.34 1.73e-10 Body mass index; CRC cis rs1448094 0.791 rs10863114 chr12:86332325 T/C cg00310523 chr12:86230176 RASSF9 0.43 7.32 0.37 1.93e-12 Major depressive disorder; CRC cis rs10789491 1.000 rs2218191 chr1:47130628 C/T cg15501359 chr1:47185051 KIAA0494 0.57 7.45 0.38 8.11e-13 Response to hepatitis C treatment; CRC cis rs57221529 0.709 rs72706611 chr5:561146 C/A cg16447950 chr5:562315 NA -0.83 -11.29 -0.53 3.41e-25 Lung disease severity in cystic fibrosis; CRC cis rs72945132 0.882 rs3133179 chr11:70187574 T/G cg00319359 chr11:70116639 PPFIA1 0.65 7.24 0.37 3.14e-12 Coronary artery disease; CRC cis rs11191205 0.644 rs10883665 chr10:103374233 G/A cg15320455 chr10:103880129 LDB1 0.58 6.4 0.33 5.47e-10 Intelligence (multi-trait analysis); CRC cis rs9911578 1.000 rs8079774 chr17:56908188 A/G cg05425664 chr17:57184151 TRIM37 -0.49 -7.73 -0.39 1.33e-13 Intelligence (multi-trait analysis); CRC cis rs11148252 0.669 rs61958050 chr13:52994427 A/C cg00495681 chr13:53174319 NA 0.56 7.74 0.39 1.22e-13 Lewy body disease; CRC cis rs68170813 0.521 rs75035695 chr7:106818731 T/C cg02696742 chr7:106810147 HBP1 -0.62 -6.81 -0.35 4.67e-11 Coronary artery disease; CRC cis rs7224314 1.000 rs7219229 chr17:65380171 C/T cg01507342 chr17:65387096 PITPNC1 -0.57 -8.03 -0.4 1.71e-14 Diisocyanate-induced asthma; CRC cis rs6951245 1.000 rs79765398 chr7:1073764 A/G cg22907277 chr7:1156413 C7orf50 0.71 7.36 0.38 1.44e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs4853012 0.941 rs78128123 chr2:74347525 C/T cg20891558 chr2:74357851 NA 0.71 10.45 0.5 2.87e-22 Gestational age at birth (maternal effect); CRC cis rs3749237 0.964 rs7431078 chr3:49808190 G/A cg05072774 chr3:49840536 C3orf54 -0.43 -5.74 -0.3 2.15e-8 Resting heart rate; CRC cis rs10992471 0.756 rs10115222 chr9:95128149 C/T cg14631576 chr9:95140430 CENPP 0.37 6.91 0.36 2.48e-11 Visceral adipose tissue/subcutaneous adipose tissue ratio; CRC cis rs10540 1.000 rs61876323 chr11:462855 G/A cg03352830 chr11:487213 PTDSS2 0.67 7.86 0.4 5.71e-14 Body mass index; CRC cis rs763121 0.785 rs5757199 chr22:39040617 T/G cg06544989 chr22:39130855 UNC84B 0.44 6.84 0.35 3.76e-11 Menopause (age at onset); CRC cis rs7647973 1.000 rs2312462 chr3:49601255 A/G cg20833759 chr3:49053208 WDR6;DALRD3 0.52 7.87 0.4 5.28e-14 Menarche (age at onset); CRC cis rs11148252 0.595 rs9526974 chr13:53251040 C/G cg02158880 chr13:53174818 NA 0.55 8.69 0.43 1.73e-16 Lewy body disease; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg22050555 chr5:171615449 STK10 0.36 6.26 0.33 1.17e-9 Liver disease severity in Alagille syndrome; CRC trans rs875971 0.660 rs2191268 chr7:66110224 C/T cg16725723 chr3:68925535 FAM19A4 -0.37 -6.01 -0.31 4.79e-9 Aortic root size; CRC cis rs7666738 0.830 rs1426662 chr4:98990319 C/T cg05340658 chr4:99064831 C4orf37 0.61 9.55 0.47 3.06e-19 Colonoscopy-negative controls vs population controls; CRC cis rs2014572 0.933 rs8109882 chr19:57755618 C/G cg24459738 chr19:57751996 ZNF805 -0.52 -8.14 -0.41 8.01e-15 Hyperactive-impulsive symptoms; CRC cis rs763014 0.932 rs2384974 chr16:651279 C/G cg00908189 chr16:619842 PIGQ 0.71 12.23 0.56 1.33e-28 Height; CRC trans rs35110281 0.627 rs56369437 chr21:44970275 A/G cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.43 6.84 0.35 3.85e-11 Mean corpuscular volume; CRC cis rs6701037 0.566 rs10489326 chr1:175134677 A/G cg00321850 chr1:175162397 KIAA0040 0.45 7.54 0.38 4.47e-13 Alcohol dependence; CRC cis rs12497850 0.863 rs4858799 chr3:48728204 G/A cg00383909 chr3:49044727 WDR6 0.76 7.66 0.39 2.03e-13 Parkinson's disease; CRC cis rs1129187 0.902 rs6907751 chr6:42944850 C/T cg21280719 chr6:42927975 GNMT -0.44 -9.84 -0.48 3.39e-20 Alzheimer's disease in APOE e4+ carriers; CRC cis rs11123610 0.520 rs7576146 chr2:3718393 A/C cg25251562 chr2:3704773 ALLC -0.49 -6.12 -0.32 2.62e-9 Response to inhaled corticosteroid treatment in asthma (change in FEV1); CRC cis rs501120 1.000 rs522293 chr10:44756703 G/A cg09554077 chr10:44749378 NA 0.78 12.0 0.55 9.18e-28 Coronary artery disease;Coronary heart disease; CRC cis rs9814567 1.000 rs2373865 chr3:134291556 C/T cg06109529 chr3:134205091 CEP63;ANAPC13 0.83 12.18 0.56 1.98e-28 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC trans rs6546324 0.625 rs2861698 chr2:67854808 A/G cg00907274 chr3:27498161 SLC4A7 -0.49 -6.21 -0.32 1.6e-9 Endometriosis; CRC cis rs6582630 0.519 rs1851130 chr12:38507819 C/T cg13010199 chr12:38710504 ALG10B 0.47 6.34 0.33 7.68e-10 Drug-induced liver injury (flucloxacillin); CRC cis rs7249142 0.549 rs2239369 chr19:19292405 A/T cg08207377 chr19:19281140 LOC729991-MEF2B;MEF2B 0.37 5.94 0.31 7.45e-9 IgG glycosylation; CRC trans rs11148252 0.538 rs9535879 chr13:52704624 T/A cg18335740 chr13:41363409 SLC25A15 0.53 8.03 0.4 1.73e-14 Lewy body disease; CRC cis rs3617 0.598 rs56214994 chr3:52878600 G/C cg15147215 chr3:52552868 STAB1 0.51 8.9 0.44 3.79e-17 Red blood cell count;Autism spectrum disorder or schizophrenia; CRC cis rs3857536 0.813 rs1891599 chr6:66941699 A/G cg07460842 chr6:66804631 NA -0.43 -5.81 -0.3 1.48e-8 Blood trace element (Cu levels); CRC cis rs34779708 0.931 rs2384287 chr10:35340559 A/G cg03585969 chr10:35415529 CREM 0.65 8.78 0.44 9.01e-17 Inflammatory bowel disease;Crohn's disease; CRC cis rs7666738 0.830 rs6830124 chr4:99054872 C/T cg05340658 chr4:99064831 C4orf37 -0.6 -9.29 -0.46 2.22e-18 Colonoscopy-negative controls vs population controls; CRC cis rs9393692 0.905 rs6916289 chr6:26289122 A/T cg13736514 chr6:26305472 NA -0.61 -11.28 -0.53 3.72e-25 Educational attainment; CRC cis rs478304 0.593 rs4645933 chr11:65485120 C/T cg27068330 chr11:65405492 SIPA1 -0.71 -10.73 -0.51 3.17e-23 Acne (severe); CRC trans rs3793427 0.877 rs3213600 chr8:17074640 C/G cg09855739 chr12:58027032 B4GALNT1 -0.41 -6.14 -0.32 2.36e-9 Tonometry; CRC cis rs2721195 0.967 rs748193 chr8:145682115 C/T cg11211951 chr8:145729740 GPT 0.42 7.41 0.38 1.11e-12 Age at first birth; CRC cis rs6499255 1.000 rs60231938 chr16:69830415 G/A cg04110750 chr16:69646130 NFAT5 -0.52 -6.99 -0.36 1.58e-11 IgE levels; CRC cis rs6502050 0.871 rs8066970 chr17:80076051 T/C cg13198984 chr17:80129470 CCDC57 -0.46 -7.98 -0.4 2.39e-14 Life satisfaction; CRC cis rs561341 0.883 rs1034627 chr17:30219569 C/T cg23018236 chr17:30244563 NA -0.43 -5.69 -0.3 2.83e-8 Hip circumference adjusted for BMI; CRC cis rs514406 0.825 rs3863643 chr1:53224577 C/T cg08859206 chr1:53392774 SCP2 0.42 6.56 0.34 2.14e-10 Monocyte count; CRC cis rs365302 1.000 rs475074 chr6:159648058 G/T cg14500486 chr6:159655392 FNDC1 0.44 6.82 0.35 4.31e-11 Coronary heart disease; CRC cis rs739401 0.611 rs7109088 chr11:3027485 G/T cg25174290 chr11:3078921 CARS 0.48 7.42 0.38 9.78e-13 Longevity; CRC cis rs11719291 0.504 rs71324924 chr3:48865444 G/A cg00383909 chr3:49044727 WDR6 1.31 12.52 0.57 1.13e-29 Cognitive function; CRC cis rs907683 0.546 rs1058261 chr2:220285309 C/T cg15015639 chr2:220282977 DES -0.4 -6.67 -0.35 1.06e-10 Resting heart rate; CRC trans rs2018683 0.707 rs917219 chr7:28975343 A/G cg19402173 chr7:128379420 CALU -0.44 -6.31 -0.33 8.81e-10 Response to irinotecan and platinum-based chemotherapy in non-small-cell lung cancer; CRC cis rs7843479 0.965 rs9314269 chr8:21804989 A/G cg17168535 chr8:21777572 XPO7 0.56 8.88 0.44 4.36e-17 Mean corpuscular volume; CRC cis rs2739330 0.828 rs2154593 chr22:24252085 A/G cg11905131 chr22:24372483 LOC391322 -0.73 -11.46 -0.53 8.21e-26 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs1448094 0.511 rs7968059 chr12:86163606 A/G cg02569458 chr12:86230093 RASSF9 0.47 7.72 0.39 1.42e-13 Major depressive disorder; CRC cis rs798554 1.000 rs798554 chr7:2759795 C/T cg13628971 chr7:2884303 GNA12 0.5 6.85 0.35 3.56e-11 Height; CRC cis rs769267 1.000 rs1009136 chr19:19440428 A/G cg01262667 chr19:19385393 TM6SF2 -0.38 -6.34 -0.33 7.49e-10 Tonsillectomy; CRC cis rs3617 0.539 rs11130331 chr3:52956918 G/A cg18099408 chr3:52552593 STAB1 0.33 5.63 0.3 3.95e-8 Red blood cell count;Autism spectrum disorder or schizophrenia; CRC cis rs2072499 0.966 rs2842857 chr1:156168736 T/C cg25208724 chr1:156163844 SLC25A44 1.1 27.58 0.84 1.48e-87 Testicular germ cell tumor; CRC cis rs12479064 0.671 rs62155807 chr2:100076579 G/A cg14399236 chr2:99771627 LIPT1;TSGA10 -0.61 -7.27 -0.37 2.68e-12 Chronic sinus infection; CRC cis rs4862750 0.874 rs6553027 chr4:187875777 T/C cg03452623 chr4:187889614 NA -0.89 -19.92 -0.74 1.75e-58 Lobe attachment (rater-scored or self-reported); CRC cis rs8141529 0.644 rs5752795 chr22:29178820 T/C cg15103426 chr22:29168792 CCDC117 0.61 8.89 0.44 4.24e-17 Lymphocyte counts; CRC cis rs10504229 0.724 rs72649117 chr8:58037639 A/G cg22535103 chr8:58192502 C8orf71 -0.44 -5.8 -0.3 1.55e-8 Developmental language disorder (linguistic errors); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg01600621 chr19:42681426 NA 0.37 6.05 0.32 3.87e-9 Liver disease severity in Alagille syndrome; CRC cis rs9487051 0.768 rs458185 chr6:109524074 A/G cg01475377 chr6:109611718 NA -0.34 -5.84 -0.31 1.24e-8 Reticulocyte fraction of red cells; CRC cis rs4713118 0.869 rs7773070 chr6:27728827 T/C cg12172441 chr6:28176163 NA 0.53 7.27 0.37 2.63e-12 Parkinson's disease; CRC cis rs9322817 0.691 rs17680345 chr6:105337409 A/T cg02098413 chr6:105308735 HACE1 0.46 9.22 0.45 3.78e-18 Thyroid stimulating hormone; CRC cis rs4731207 0.596 rs922712 chr7:124607050 C/T cg23710748 chr7:124431027 NA -0.38 -6.08 -0.32 3.35e-9 Cutaneous malignant melanoma; CRC cis rs728616 0.867 rs12414096 chr10:81713629 A/G cg11900509 chr10:81946545 ANXA11 -0.68 -6.79 -0.35 5.37e-11 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs735396 0.627 rs2264778 chr12:121450354 C/A cg02403541 chr12:121454288 C12orf43 0.55 8.52 0.43 5.93e-16 N-glycan levels; CRC cis rs7918232 0.505 rs788221 chr10:27442247 G/C cg14240646 chr10:27532245 ACBD5 0.9 9.0 0.44 1.88e-17 Breast cancer; CRC cis rs1218582 0.772 rs2174507 chr1:154887949 C/T cg24250549 chr1:154909240 PMVK 0.65 11.35 0.53 1.97e-25 Prostate cancer; CRC trans rs8123881 0.733 rs7268466 chr20:15810676 C/T cg19385725 chr18:21166173 NPC1 0.53 6.14 0.32 2.43e-9 Body mass index; CRC cis rs7927592 0.871 rs12360903 chr11:68236314 C/A cg16797656 chr11:68205561 LRP5 0.38 6.07 0.32 3.52e-9 Total body bone mineral density; CRC cis rs6963495 0.818 rs73190133 chr7:105147821 G/C cg02135003 chr7:105160482 PUS7 -0.89 -12.26 -0.56 9.87e-29 Bipolar disorder (body mass index interaction); CRC cis rs7503807 0.935 rs9910745 chr17:78610543 C/T cg09596252 chr17:78655493 RPTOR 0.4 6.25 0.33 1.31e-9 Obesity; CRC cis rs477692 0.905 rs555545 chr10:131411586 G/A cg05714579 chr10:131428358 MGMT 0.56 8.18 0.41 6.17e-15 Response to temozolomide; CRC cis rs863345 0.604 rs11264997 chr1:158485482 C/T cg12129480 chr1:158549410 OR10X1 -0.3 -6.24 -0.33 1.32e-9 Pneumococcal bacteremia; CRC cis rs11203032 0.831 rs4399251 chr10:90943634 A/C cg16672925 chr10:90967113 CH25H 0.44 5.67 0.3 3.13e-8 Heart failure; CRC cis rs11864453 0.612 rs11862813 chr16:72132356 C/T cg23815491 chr16:72088622 HP 0.51 7.78 0.39 9.45e-14 Fibrinogen levels; CRC cis rs9556958 0.708 rs9513435 chr13:99160334 C/G cg15168958 chr13:99100528 FARP1 0.4 6.39 0.33 5.65e-10 Educational attainment (years of education); CRC cis rs11148252 0.508 rs1886542 chr13:52706281 A/C cg12458913 chr13:53173898 NA 0.46 6.77 0.35 5.99e-11 Lewy body disease; CRC cis rs7811142 1.000 rs2406255 chr7:100053690 T/C cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.73 9.54 0.47 3.46e-19 Platelet count; CRC cis rs6879260 0.963 rs1035412 chr5:179729328 C/T cg13944838 chr5:179740914 GFPT2 -0.73 -11.69 -0.54 1.22e-26 Height; CRC cis rs2933343 0.700 rs1680778 chr3:128614185 A/C cg11901034 chr3:128598214 ACAD9 -0.57 -8.35 -0.42 1.92e-15 IgG glycosylation; CRC cis rs763121 0.785 rs5750646 chr22:39013830 T/C cg06022373 chr22:39101656 GTPBP1 0.8 13.37 0.59 7.59e-33 Menopause (age at onset); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg02921350 chr14:69260300 ZFP36L1 0.39 6.77 0.35 5.85e-11 Liver disease severity in Alagille syndrome; CRC cis rs10504229 0.683 rs903706 chr8:58128134 T/G cg22535103 chr8:58192502 C8orf71 -0.7 -9.34 -0.46 1.47e-18 Developmental language disorder (linguistic errors); CRC cis rs2075371 0.932 rs1862052 chr7:133981227 G/A cg11752832 chr7:134001865 SLC35B4 0.43 6.28 0.33 1.07e-9 Mean platelet volume; CRC cis rs11148252 0.819 rs7336679 chr13:53043333 G/A cg02158880 chr13:53174818 NA 0.47 6.82 0.35 4.38e-11 Lewy body disease; CRC cis rs4711336 1.000 rs2296738 chr6:33656850 C/T cg14003231 chr6:33640908 ITPR3 0.53 8.33 0.42 2.26e-15 Height; CRC cis rs6604026 0.656 rs34389767 chr1:93373780 T/G cg17283838 chr1:93427260 FAM69A 0.43 5.79 0.3 1.61e-8 Multiple sclerosis; CRC cis rs4665809 1.000 rs10202478 chr2:26276049 T/C cg22920501 chr2:26401640 FAM59B -0.57 -7.88 -0.4 4.86e-14 Gut microbiome composition (summer); CRC trans rs4263408 0.934 rs9683743 chr4:39703194 A/C cg02062003 chr11:117187060 BACE1 -0.43 -6.47 -0.34 3.52e-10 Plasma amyloid beta peptide concentrations (ABx-40); CRC cis rs9467711 0.606 rs12174623 chr6:26373086 C/T cg16898833 chr6:26189333 HIST1H4D 0.76 6.58 0.34 1.84e-10 Autism spectrum disorder or schizophrenia; CRC cis rs9868809 0.772 rs9812977 chr3:48720303 G/A cg00383909 chr3:49044727 WDR6 1.03 9.52 0.46 3.94e-19 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; CRC cis rs3008870 0.755 rs2815363 chr1:67497221 A/G cg08660285 chr1:67390436 MIER1;WDR78 -0.55 -7.76 -0.39 1.11e-13 Lymphocyte percentage of white cells; CRC cis rs870825 0.616 rs7692104 chr4:185650895 T/G cg04058563 chr4:185651563 MLF1IP 0.72 9.28 0.46 2.4e-18 Blood protein levels; CRC cis rs10504229 1.000 rs17805602 chr8:58179915 A/G cg02725872 chr8:58115012 NA -0.38 -6.43 -0.33 4.44e-10 Developmental language disorder (linguistic errors); CRC trans rs2228479 0.717 rs17233678 chr16:89809962 T/C cg24644049 chr4:85504048 CDS1 0.9 7.41 0.38 1.05e-12 Skin colour saturation; CRC cis rs7666738 0.830 rs6831219 chr4:98993576 C/A cg17366294 chr4:99064904 C4orf37 0.44 7.39 0.38 1.19e-12 Colonoscopy-negative controls vs population controls; CRC cis rs9325144 0.555 rs2387847 chr12:38687434 C/T cg26384229 chr12:38710491 ALG10B 0.54 8.16 0.41 7.11e-15 Morning vs. evening chronotype; CRC cis rs9381040 0.655 rs6939989 chr6:41020205 A/G cg03644281 chr6:41068752 NFYA;LOC221442 -0.42 -6.1 -0.32 3.03e-9 Alzheimer's disease (late onset); CRC cis rs1448094 0.511 rs11117042 chr12:86207547 G/T cg00310523 chr12:86230176 RASSF9 0.39 6.66 0.34 1.15e-10 Major depressive disorder; CRC cis rs6793245 0.845 rs4073797 chr3:38590850 A/T cg01465620 chr3:38496096 LOC100128640;ACVR2B -0.56 -8.26 -0.41 3.53e-15 QT interval; CRC trans rs1005277 0.579 rs2472183 chr10:38392495 T/G cg17830980 chr10:43048298 ZNF37B -0.6 -9.96 -0.48 1.3e-20 Extrinsic epigenetic age acceleration; CRC cis rs4713675 0.584 rs9368776 chr6:33696405 A/G cg14003231 chr6:33640908 ITPR3 0.5 8.15 0.41 7.53e-15 Plateletcrit; CRC cis rs10924970 0.967 rs10925192 chr1:235400826 T/C cg26050004 chr1:235667680 B3GALNT2 0.39 5.78 0.3 1.71e-8 Asthma; CRC cis rs10504229 0.683 rs6995355 chr8:58113870 C/T cg22535103 chr8:58192502 C8orf71 -0.69 -9.23 -0.45 3.37e-18 Developmental language disorder (linguistic errors); CRC cis rs853679 0.517 rs9468298 chr6:28122345 A/G cg12963246 chr6:28129442 ZNF389 0.49 5.7 0.3 2.71e-8 Depression; CRC cis rs9311474 0.629 rs7636227 chr3:52566682 G/A cg13284614 chr3:52569169 NT5DC2;LOC440957 0.34 5.66 0.3 3.27e-8 Electroencephalogram traits; CRC cis rs10504073 0.584 rs4873306 chr8:49950369 T/C cg00325661 chr8:49890786 NA 0.57 10.25 0.49 1.36e-21 Blood metabolite ratios; CRC cis rs7213347 0.780 rs9892016 chr17:2146422 A/G cg24045832 chr17:1955481 NA 0.39 6.29 0.33 1.02e-9 Total body bone mineral density; CRC cis rs736408 0.677 rs2286798 chr3:52821177 G/T cg10802521 chr3:52805072 NEK4 0.51 7.76 0.39 1.08e-13 Bipolar disorder; CRC cis rs1997103 1.000 rs12532070 chr7:55407698 A/G cg17469321 chr7:55412551 NA 0.72 11.28 0.53 3.48e-25 QRS interval (sulfonylurea treatment interaction); CRC cis rs13108904 0.901 rs1316394 chr4:1315820 G/A cg00684032 chr4:1343700 KIAA1530 0.49 7.32 0.37 1.94e-12 Obesity-related traits; CRC cis rs56114371 0.568 rs200468 chr6:27757855 C/G cg15845792 chr6:28175446 NA 0.5 5.83 0.31 1.32e-8 Breast cancer; CRC cis rs7945718 0.875 rs7105783 chr11:12719794 A/G cg25843174 chr11:12811716 TEAD1 0.45 8.4 0.42 1.35e-15 Educational attainment (years of education); CRC cis rs853679 0.517 rs9380062 chr6:28137569 G/A cg25164649 chr6:28176230 NA 0.78 9.66 0.47 1.33e-19 Depression; CRC cis rs6499255 1.000 rs12925371 chr16:69773885 G/A cg04110750 chr16:69646130 NFAT5 -0.54 -7.21 -0.37 3.78e-12 IgE levels; CRC cis rs9549367 0.789 rs9549716 chr13:113908478 G/A cg00898013 chr13:113819073 PROZ -0.45 -6.45 -0.33 4.06e-10 Platelet distribution width; CRC cis rs12477438 0.520 rs6739579 chr2:99731552 C/T cg26064155 chr2:99771622 LIPT1;TSGA10 0.87 15.91 0.66 1.13e-42 Chronic sinus infection; CRC cis rs28386778 0.897 rs2584635 chr17:61865934 A/G cg22520471 chr17:61851767 DDX42;CCDC47 0.76 11.7 0.54 1.1e-26 Prudent dietary pattern; CRC cis rs2832191 0.716 rs1543652 chr21:30448000 G/C cg24692254 chr21:30365293 RNF160 0.84 15.82 0.66 2.67e-42 Dental caries; CRC cis rs1887596 0.705 rs498498 chr13:27221206 G/A cg01312412 chr13:27282625 NA 0.43 5.83 0.31 1.32e-8 Facial morphology (factor 3, length of philtrum); CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg08052428 chr9:135996421 RALGDS -0.51 -6.32 -0.33 8.69e-10 Diisocyanate-induced asthma; CRC cis rs9303280 0.806 rs13380815 chr17:38027583 A/G cg00129232 chr17:37814104 STARD3 -0.46 -7.24 -0.37 3.1e-12 Self-reported allergy; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg14538439 chr10:90750381 FAS;ACTA2 0.38 6.29 0.33 1.04e-9 Liver disease severity in Alagille syndrome; CRC cis rs6121246 0.559 rs6058465 chr20:30397691 G/A cg13852791 chr20:30311386 BCL2L1 0.8 15.91 0.66 1.15e-42 Mean corpuscular hemoglobin; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg10721359 chr6:26538456 HMGN4 0.48 6.75 0.35 6.82e-11 Response to antipsychotic treatment; CRC cis rs6674176 0.561 rs12127226 chr1:44395309 C/T cg13606994 chr1:44402422 ARTN -0.38 -6.35 -0.33 6.97e-10 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Cognitive ability; CRC cis rs453301 0.686 rs7814328 chr8:8876229 T/C cg06636001 chr8:8085503 FLJ10661 -0.48 -7.14 -0.37 6.11e-12 Joint mobility (Beighton score); CRC cis rs6598955 0.670 rs6663950 chr1:26560131 T/C cg00852783 chr1:26633632 UBXN11 0.43 6.96 0.36 1.89e-11 Obesity-related traits; CRC cis rs11958404 0.932 rs11950297 chr5:157419938 T/G cg05962755 chr5:157440814 NA 0.95 12.54 0.57 9.76e-30 IgG glycosylation; CRC cis rs6754311 0.731 rs2236783 chr2:136594158 G/A cg25344623 chr2:136566232 LCT 0.32 5.93 0.31 7.48e-9 Mosquito bite size; CRC cis rs1552244 0.882 rs55808392 chr3:10054681 C/T cg16606324 chr3:10149918 C3orf24 0.62 7.91 0.4 3.93e-14 Alzheimer's disease; CRC trans rs6598955 0.585 rs6659822 chr1:26626408 C/A cg07461501 chr17:79650226 HGS;ARL16 -0.5 -6.05 -0.32 4.04e-9 Obesity-related traits; CRC cis rs7312933 0.528 rs10880238 chr12:42489613 A/G cg17420585 chr12:42539391 GXYLT1 -0.65 -11.22 -0.53 5.83e-25 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CRC cis rs8141529 0.732 rs3788409 chr22:29198151 T/G cg02153584 chr22:29168773 CCDC117 0.53 7.88 0.4 4.86e-14 Lymphocyte counts; CRC cis rs7727544 0.642 rs7705189 chr5:131623358 C/T cg18758796 chr5:131593413 PDLIM4 -0.33 -5.79 -0.3 1.63e-8 Blood metabolite levels; CRC cis rs921968 0.541 rs2556391 chr2:219556346 T/C cg02176678 chr2:219576539 TTLL4 -0.58 -9.27 -0.46 2.49e-18 Mean corpuscular hemoglobin concentration; CRC cis rs6540556 0.723 rs10863785 chr1:209908876 C/T cg05527609 chr1:210001259 C1orf107 0.54 6.19 0.32 1.8e-9 Red blood cell count; CRC cis rs883565 0.606 rs883349 chr3:39067925 T/C cg01426195 chr3:39028469 NA -0.47 -7.85 -0.4 5.9e-14 Handedness; CRC cis rs40363 0.723 rs757269 chr16:3538003 A/G cg22508957 chr16:3507546 NAT15 -0.81 -8.98 -0.44 2.13e-17 Tuberculosis; CRC cis rs9659323 0.745 rs10923723 chr1:119544002 G/A cg26570165 chr1:119541833 NA -0.43 -7.15 -0.37 5.81e-12 Body mass index; CRC cis rs1552244 1.000 rs6793396 chr3:10110927 T/C cg10729496 chr3:10149963 C3orf24 0.55 7.26 0.37 2.73e-12 Alzheimer's disease; CRC cis rs9443645 0.869 rs1507154 chr6:79503700 C/T cg09184832 chr6:79620586 NA -0.49 -9.24 -0.45 3.1e-18 Intelligence (multi-trait analysis); CRC cis rs8077889 0.871 rs11079838 chr17:41898971 G/A cg16892393 chr17:41919603 NA 0.47 7.24 0.37 3.23e-12 Triglycerides; CRC cis rs9901225 1 rs9901225 chr17:40755811 C/T cg03582285 chr17:40700314 NA -0.42 -7.85 -0.4 5.76e-14 Colorectal or endometrial cancer; CRC cis rs3733585 0.781 rs57250714 chr4:9984529 C/T cg00071950 chr4:10020882 SLC2A9 0.54 9.45 0.46 6.46e-19 Cleft plate (environmental tobacco smoke interaction); CRC trans rs2797160 1.000 rs6910933 chr6:126017155 C/G cg05039488 chr6:79577232 IRAK1BP1 0.5 7.47 0.38 7.32e-13 Endometrial cancer; CRC cis rs2062225 1.000 rs11679341 chr2:111758579 T/C cg11729679 chr2:111877065 BCL2L11 -0.56 -5.64 -0.3 3.67e-8 Monocyte count; CRC cis rs2346177 0.846 rs62138876 chr2:46650672 C/A cg26688816 chr2:46740690 ATP6V1E2 -0.51 -8.3 -0.42 2.69e-15 HDL cholesterol; CRC cis rs2976388 0.590 rs10087426 chr8:143814554 G/A cg24634471 chr8:143751801 JRK -0.43 -6.06 -0.32 3.64e-9 Urinary tract infection frequency; CRC cis rs1577917 1.000 rs7756203 chr6:86627707 T/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.52 -6.78 -0.35 5.63e-11 Response to antipsychotic treatment; CRC cis rs8177253 0.965 rs4854762 chr3:133499063 A/G cg01448562 chr3:133502909 NA 0.55 9.4 0.46 9.53e-19 Iron status biomarkers; CRC cis rs17376456 0.877 rs7701011 chr5:93311456 G/A cg25358565 chr5:93447407 FAM172A 1.06 10.59 0.5 9.22e-23 Diabetic retinopathy; CRC trans rs1997103 1.000 rs4948012 chr7:55412578 A/C cg20935933 chr6:143382018 AIG1 0.49 6.46 0.34 3.8e-10 QRS interval (sulfonylurea treatment interaction); CRC cis rs7726839 0.507 rs56282020 chr5:596701 T/C cg16447950 chr5:562315 NA -0.73 -9.65 -0.47 1.41e-19 Obesity-related traits; CRC cis rs2839186 0.709 rs2156117 chr21:47669300 C/A cg13012494 chr21:47604986 C21orf56 0.43 6.78 0.35 5.55e-11 Testicular germ cell tumor; CRC trans rs1973993 0.689 rs67544133 chr1:96971241 G/A cg10631902 chr5:14652156 NA -0.45 -7.44 -0.38 8.86e-13 Weight; CRC cis rs11719291 0.833 rs11713694 chr3:48833615 G/T cg00383909 chr3:49044727 WDR6 1.31 12.52 0.57 1.13e-29 Cognitive function; CRC cis rs4654899 0.931 rs12723255 chr1:21233570 C/T cg02927042 chr1:21476669 EIF4G3 0.43 6.84 0.35 3.77e-11 Superior frontal gyrus grey matter volume; CRC cis rs9916302 0.610 rs11078902 chr17:37631883 C/G cg15445000 chr17:37608096 MED1 0.42 9.27 0.46 2.47e-18 Glomerular filtration rate (creatinine); CRC cis rs4665809 1.000 rs10170359 chr2:26272219 G/T cg26119090 chr2:26468346 HADHA;HADHB -0.62 -7.91 -0.4 3.86e-14 Gut microbiome composition (summer); CRC cis rs501916 0.634 rs531596 chr15:48058214 C/T cg16110827 chr15:48056943 SEMA6D -0.45 -6.78 -0.35 5.74e-11 Inflammatory bowel disease;Ulcerative colitis; CRC cis rs2976388 0.609 rs2585144 chr8:143800269 A/T cg05569086 chr8:143859399 LYNX1 0.38 6.61 0.34 1.58e-10 Urinary tract infection frequency; CRC cis rs9443645 0.901 rs55755815 chr6:79607121 G/T cg05283184 chr6:79620031 NA -0.58 -9.34 -0.46 1.48e-18 Intelligence (multi-trait analysis); CRC cis rs10208940 0.920 rs35859673 chr2:68735718 G/A cg12452813 chr2:68675892 NA 0.47 5.81 0.31 1.44e-8 Urate levels in lean individuals; CRC cis rs12295403 1.000 rs12789252 chr11:18690389 C/T cg07538406 chr11:18686895 NA -0.41 -6.15 -0.32 2.22e-9 Ovarian reserve; CRC cis rs4073416 0.542 rs2898814 chr14:66023961 T/C cg03016385 chr14:66212404 NA -0.44 -6.12 -0.32 2.62e-9 N-glycan levels; CRC cis rs4478858 0.735 rs7523509 chr1:31788329 A/G cg00250761 chr1:31883323 NA -0.39 -7.34 -0.38 1.65e-12 Alcohol dependence; CRC cis rs7737355 0.898 rs4706030 chr5:130957486 A/G cg25547332 chr5:131281432 NA 0.4 5.61 0.3 4.28e-8 Life satisfaction; CRC cis rs12540874 0.698 rs3807566 chr7:50564204 G/T cg18232548 chr7:50535776 DDC -0.52 -7.75 -0.39 1.15e-13 Systemic sclerosis; CRC cis rs13161895 0.818 rs116463976 chr5:179484519 G/C cg02702477 chr5:179499311 RNF130 0.69 7.58 0.39 3.54e-13 LDL cholesterol; CRC cis rs2811415 0.597 rs11706281 chr3:127803922 A/G cg13719885 chr3:127795394 NA -0.39 -5.9 -0.31 9.25e-9 Lung function (FEV1/FVC); CRC cis rs4409675 0.576 rs6565 chr1:28213157 T/C cg23691781 chr1:28212827 C1orf38 0.34 7.81 0.4 7.59e-14 Corneal astigmatism; CRC cis rs2153535 0.580 rs9378552 chr6:8463748 G/A cg07606381 chr6:8435919 SLC35B3 0.68 10.9 0.51 8.26e-24 Motion sickness; CRC cis rs910316 1.000 rs10873275 chr14:75531460 A/T cg11812906 chr14:75593930 NEK9 0.62 9.83 0.48 3.65e-20 Height; CRC cis rs9457247 0.663 rs2237274 chr6:167442995 C/G cg07741184 chr6:167504864 NA 0.35 6.22 0.32 1.51e-9 Crohn's disease; CRC trans rs6951245 0.554 rs4724294 chr7:1139695 G/A cg13565492 chr6:43139072 SRF -0.83 -10.59 -0.5 9.91e-23 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs7932354 0.528 rs11039097 chr11:47131881 C/T cg19486271 chr11:47235900 DDB2 -0.47 -6.85 -0.35 3.69e-11 Bone mineral density (hip);Bone mineral density; CRC cis rs1983170 0.736 rs11164909 chr1:92002506 T/C cg02896835 chr1:92012615 NA 0.52 6.26 0.33 1.2e-9 Eosinophil percentage of white cells; CRC cis rs4903604 0.581 rs4903606 chr14:78036935 A/G cg18872420 chr14:78023429 SPTLC2 0.35 6.03 0.32 4.42e-9 Gut microbiome composition (winter); CRC cis rs62229266 0.652 rs7280551 chr21:37409609 T/A cg12218747 chr21:37451666 NA -0.36 -6.2 -0.32 1.71e-9 Mitral valve prolapse; CRC cis rs6840360 0.642 rs2709825 chr4:152365563 C/A cg09659197 chr4:152720779 NA 0.34 6.7 0.35 8.91e-11 Intelligence (multi-trait analysis); CRC cis rs9914988 0.887 rs12947735 chr17:27156866 A/T cg16670446 chr17:27188758 MIR451;MIR144 0.53 8.35 0.42 1.89e-15 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs9322193 0.607 rs3798763 chr6:150211100 T/C cg07701084 chr6:150067640 NUP43 0.47 5.78 0.3 1.69e-8 Lung cancer; CRC cis rs13191362 1.000 rs1333963 chr6:163192571 A/G cg06582575 chr6:163149167 PACRG;PARK2 0.93 11.7 0.54 1.15e-26 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs2456568 0.900 rs877340 chr11:93689292 A/T cg26875233 chr11:93583750 C11orf90 -0.34 -6.58 -0.34 1.83e-10 Response to serotonin reuptake inhibitors in major depressive disorder; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg20691617 chr2:85142974 NA 0.45 6.91 0.36 2.59e-11 Liver disease severity in Alagille syndrome; CRC cis rs6912958 0.582 rs242285 chr6:88070743 G/A cg04972856 chr6:88032051 C6orf162;GJB7 0.36 6.62 0.34 1.47e-10 Monocyte percentage of white cells; CRC cis rs4713118 0.869 rs7776351 chr6:27726731 A/G cg20933634 chr6:27740509 NA -0.56 -8.26 -0.41 3.58e-15 Parkinson's disease; CRC cis rs736408 0.546 rs3733046 chr3:52621627 C/T cg18099408 chr3:52552593 STAB1 -0.47 -8.05 -0.41 1.48e-14 Bipolar disorder; CRC cis rs9522267 0.511 rs1163626 chr13:112225200 A/C cg26182253 chr13:112236782 NA 0.31 6.39 0.33 5.57e-10 Hepatitis; CRC trans rs35110281 0.713 rs1378079 chr21:45011187 A/G cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.42 6.71 0.35 8.34e-11 Mean corpuscular volume; CRC cis rs3091242 0.933 rs11249251 chr1:25770188 C/G cg27572855 chr1:25598939 RHD 0.35 6.14 0.32 2.35e-9 Erythrocyte sedimentation rate; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg20930618 chr1:151162157 VPS72 0.45 6.7 0.35 8.88e-11 Response to antipsychotic treatment; CRC cis rs9463078 0.715 rs9463076 chr6:45171362 C/T cg25276700 chr6:44698697 NA 0.24 5.91 0.31 8.62e-9 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; CRC cis rs10463316 0.780 rs6894899 chr5:150775913 C/T cg03212797 chr5:150827313 SLC36A1 -0.49 -7.82 -0.4 7.31e-14 Metabolite levels (Pyroglutamine); CRC cis rs6163 0.588 rs11191392 chr10:104526951 C/A cg04362960 chr10:104952993 NT5C2 0.48 7.06 0.36 9.76e-12 Waist circumference;Hip circumference; CRC cis rs9303280 0.628 rs12939565 chr17:38038389 A/T cg00129232 chr17:37814104 STARD3 -0.47 -7.61 -0.39 2.93e-13 Self-reported allergy; CRC cis rs28830936 1.000 rs28754734 chr15:42093152 C/T cg17847044 chr15:42102381 MAPKBP1 -0.31 -6.4 -0.33 5.45e-10 Diastolic blood pressure; CRC cis rs9322193 0.923 rs55849538 chr6:149956466 T/C cg00933542 chr6:150070202 PCMT1 0.31 6.2 0.32 1.67e-9 Lung cancer; CRC cis rs6540556 0.954 rs3753606 chr1:209937212 C/T cg23920097 chr1:209922102 NA 0.51 6.53 0.34 2.51e-10 Red blood cell count; CRC cis rs1707322 0.691 rs61784799 chr1:46177748 A/G cg06784218 chr1:46089804 CCDC17 -0.65 -12.09 -0.55 4.37e-28 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs28386778 0.863 rs2584637 chr17:61942952 T/C cg06601766 chr17:61851465 DDX42;CCDC47 0.44 6.0 0.31 5.18e-9 Prudent dietary pattern; CRC cis rs1552244 0.882 rs55962400 chr3:10044457 C/T cg16606324 chr3:10149918 C3orf24 0.59 7.21 0.37 3.78e-12 Alzheimer's disease; CRC cis rs4555082 0.794 rs2735829 chr14:105708472 C/T cg10792982 chr14:105748885 BRF1 0.35 5.87 0.31 1.06e-8 Mean platelet volume;Platelet distribution width; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg24423424 chr22:36718563 MYH9 -0.36 -6.13 -0.32 2.5e-9 Liver disease severity in Alagille syndrome; CRC trans rs2303319 0.504 rs62189055 chr2:162625749 C/A cg24655899 chr17:79519568 C17orf70 -0.7 -5.98 -0.31 5.92e-9 Cognitive function; CRC cis rs9372498 0.536 rs9481821 chr6:118846022 A/C cg18833306 chr6:118973337 C6orf204 0.44 5.86 0.31 1.14e-8 Diastolic blood pressure; CRC cis rs8180040 0.967 rs4858890 chr3:47405456 A/G cg27129171 chr3:47204927 SETD2 -0.66 -10.22 -0.49 1.73e-21 Colorectal cancer; CRC cis rs10504229 0.593 rs16921626 chr8:58040359 C/T cg22535103 chr8:58192502 C8orf71 -0.52 -6.32 -0.33 8.67e-10 Developmental language disorder (linguistic errors); CRC cis rs294883 0.865 rs426497 chr6:159698455 G/A cg14500486 chr6:159655392 FNDC1 -0.36 -5.82 -0.31 1.4e-8 Coronary artery disease; CRC trans rs3960554 0.741 rs10232162 chr7:75702505 C/T cg19862616 chr7:65841803 NCRNA00174 0.73 8.61 0.43 3.13e-16 Eotaxin levels; CRC cis rs929354 0.772 rs3802124 chr7:156970609 G/A cg16102536 chr7:156981717 UBE3C 0.4 6.69 0.35 9.57e-11 Body mass index; CRC cis rs644799 0.710 rs12272061 chr11:95524067 G/T cg25478527 chr11:95522999 CEP57;FAM76B 0.49 7.62 0.39 2.66e-13 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs10751667 0.580 rs7395515 chr11:1005160 C/T ch.11.42038R chr11:967971 AP2A2 0.57 9.04 0.45 1.37e-17 Alzheimer's disease (late onset); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg16664859 chr1:226309452 NA 0.39 6.06 0.32 3.8e-9 Liver disease severity in Alagille syndrome; CRC cis rs10191773 0.589 rs72831634 chr2:112946796 A/G cg23609528 chr2:113191194 RGPD5;RGPD8 0.66 5.67 0.3 3.18e-8 Yeast infection; CRC cis rs2032447 0.867 rs9295683 chr6:26069495 C/T cg03264133 chr6:25882463 NA -0.4 -5.69 -0.3 2.83e-8 Intelligence (multi-trait analysis); CRC cis rs79149102 0.579 rs76900720 chr15:75348895 A/T cg09165964 chr15:75287851 SCAMP5 -0.63 -5.62 -0.3 3.98e-8 Lung cancer; CRC cis rs863345 0.604 rs10908658 chr1:158465256 A/G cg12129480 chr1:158549410 OR10X1 -0.3 -6.29 -0.33 9.9e-10 Pneumococcal bacteremia; CRC cis rs9534288 0.699 rs1467665 chr13:46662919 C/T cg15192986 chr13:46630673 CPB2 -0.69 -9.04 -0.45 1.37e-17 Blood protein levels; CRC cis rs1799949 1.000 rs11657053 chr17:41191129 G/T cg19454999 chr17:41278357 BRCA1;NBR2 0.53 7.99 0.4 2.31e-14 Menopause (age at onset); CRC cis rs55675132 0.510 rs12136319 chr1:115298525 T/C cg12756093 chr1:115239321 AMPD1 0.52 6.24 0.33 1.34e-9 Schizophrenia; CRC cis rs28830936 0.528 rs11630242 chr15:42124643 T/C cg17847044 chr15:42102381 MAPKBP1 -0.34 -8.12 -0.41 9.28e-15 Diastolic blood pressure; CRC cis rs7538876 0.935 rs4920607 chr1:17760098 A/G cg07965774 chr1:17746286 RCC2 0.35 6.31 0.33 8.95e-10 Basal cell carcinoma; CRC cis rs6831352 0.959 rs6848050 chr4:100053733 T/C cg12011299 chr4:100065546 ADH4 0.53 10.92 0.52 6.76e-24 Alcohol dependence; CRC cis rs17376456 0.877 rs28575883 chr5:93346035 T/C cg25358565 chr5:93447407 FAM172A 1.07 10.71 0.51 3.56e-23 Diabetic retinopathy; CRC cis rs1057239 0.510 rs3766694 chr1:175143207 T/C cg14847009 chr1:175162515 KIAA0040 -0.29 -6.37 -0.33 6.33e-10 Diastolic blood pressure; CRC cis rs13108904 0.870 rs4974543 chr4:1251222 A/G cg16405210 chr4:1374714 KIAA1530 -0.43 -6.1 -0.32 2.91e-9 Obesity-related traits; CRC cis rs9381040 0.655 rs4140578 chr6:41041829 A/G cg04346459 chr6:41068666 NFYA;LOC221442 -0.42 -6.22 -0.32 1.49e-9 Alzheimer's disease (late onset); CRC trans rs10982213 0.830 rs2274163 chr9:117188714 C/T cg00207794 chr3:24161207 THRB 0.38 6.06 0.32 3.73e-9 Interleukin-6 levels; CRC cis rs4076764 0.846 rs4255362 chr1:163424630 G/A cg06092702 chr1:163392909 NA -0.54 -8.53 -0.43 5.46e-16 Motion sickness; CRC cis rs12745968 0.589 rs10874710 chr1:93017763 A/G cg17283838 chr1:93427260 FAM69A -0.48 -6.36 -0.33 6.91e-10 Bipolar disorder and schizophrenia; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg13591723 chr12:46765135 SLC38A2 0.45 6.34 0.33 7.48e-10 Response to antipsychotic treatment; CRC cis rs11758351 0.660 rs77337633 chr6:26233610 T/C cg10723962 chr6:26240782 HIST1H4F -0.39 -6.27 -0.33 1.15e-9 Gout;Renal underexcretion gout; CRC cis rs2456568 0.570 rs1518579 chr11:93656821 A/G cg26875233 chr11:93583750 C11orf90 -0.37 -7.03 -0.36 1.23e-11 Response to serotonin reuptake inhibitors in major depressive disorder; CRC cis rs2153535 0.580 rs6938071 chr6:8464845 A/T cg21535247 chr6:8435926 SLC35B3 0.5 7.51 0.38 5.79e-13 Motion sickness; CRC cis rs9788333 0.888 rs35880230 chr13:21885972 A/G cg21970626 chr13:21893289 NA -0.45 -8.37 -0.42 1.65e-15 Thiazide-induced adverse metabolic effects in hypertensive patients; CRC cis rs10979 0.965 rs9390109 chr6:143892806 T/C cg25407410 chr6:143891975 LOC285740 -0.83 -13.72 -0.6 3.57e-34 Hypospadias; CRC cis rs2880765 0.835 rs4842887 chr15:86035810 T/C cg17133734 chr15:86042851 AKAP13 0.42 6.66 0.34 1.17e-10 Coronary artery disease; CRC cis rs8060686 0.641 rs12448677 chr16:68209741 G/A cg26727032 chr16:67993705 SLC12A4 -0.53 -6.24 -0.33 1.37e-9 HDL cholesterol;Metabolic syndrome; CRC cis rs514406 0.929 rs564273 chr1:53332445 G/C cg27535305 chr1:53392650 SCP2 -0.37 -6.99 -0.36 1.5e-11 Monocyte count; CRC cis rs8180040 0.764 rs11712716 chr3:47193432 T/C cg27129171 chr3:47204927 SETD2 0.68 11.12 0.52 1.36e-24 Colorectal cancer; CRC cis rs1799949 0.930 rs1554063 chr17:41287145 T/C cg23758822 chr17:41437982 NA 0.85 15.74 0.66 5.45e-42 Menopause (age at onset); CRC cis rs2404602 0.608 rs12439484 chr15:76602937 A/C cg23625390 chr15:77176239 SCAPER 0.39 5.72 0.3 2.34e-8 Blood metabolite levels; CRC trans rs9467711 0.584 rs34244947 chr6:26761745 T/C cg06606381 chr12:133084897 FBRSL1 -1.08 -7.42 -0.38 1.03e-12 Autism spectrum disorder or schizophrenia; CRC trans rs3733585 0.631 rs4697925 chr4:10124330 G/C cg26043149 chr18:55253948 FECH -0.54 -7.56 -0.38 4.16e-13 Cleft plate (environmental tobacco smoke interaction); CRC trans rs7690467 0.757 rs55661838 chr4:133404548 C/A cg19296258 chr17:78878799 RPTOR -0.47 -6.34 -0.33 7.41e-10 Eating disorders; CRC cis rs6835098 0.509 rs2332655 chr4:174093002 A/G cg08422745 chr4:174089978 GALNT7 0.63 10.01 0.48 9.3e-21 Dementia and core Alzheimer's disease neuropathologic changes; CRC cis rs1348850 0.831 rs7606235 chr2:178401288 T/C cg02961200 chr2:178257176 LOC100130691;AGPS 0.56 7.87 0.4 5.16e-14 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs2242116 0.796 rs4587 chr3:46963502 T/C cg27129171 chr3:47204927 SETD2 0.63 9.04 0.45 1.35e-17 Birth weight; CRC trans rs8123881 0.733 rs7268466 chr20:15810676 C/T cg25008156 chr6:170893875 PDCD2 0.56 6.02 0.31 4.72e-9 Body mass index; CRC cis rs7666738 0.830 rs35235971 chr4:98999833 G/T cg17366294 chr4:99064904 C4orf37 0.44 7.39 0.38 1.19e-12 Colonoscopy-negative controls vs population controls; CRC cis rs4713118 0.513 rs149962 chr6:28015918 G/A cg02683197 chr6:28174875 NA 0.61 8.37 0.42 1.68e-15 Parkinson's disease; CRC cis rs798766 0.779 rs55895920 chr4:1735930 C/T cg05874882 chr4:1763078 NA -0.39 -7.01 -0.36 1.32e-11 Bladder cancer;Urinary bladder cancer; CRC cis rs6088580 0.634 rs2378134 chr20:32938085 C/T cg24642439 chr20:33292090 TP53INP2 -0.4 -6.7 -0.35 9.1e-11 Glomerular filtration rate (creatinine); CRC cis rs2495707 0.624 rs2489007 chr10:102422046 A/G cg22689833 chr10:102415991 NA 0.35 6.83 0.35 4.24e-11 Body mass index; CRC cis rs9911578 0.874 rs302865 chr17:56756977 A/G cg05425664 chr17:57184151 TRIM37 -0.49 -7.76 -0.39 1.08e-13 Intelligence (multi-trait analysis); CRC cis rs35306767 0.903 rs35968821 chr10:910225 A/G cg20503657 chr10:835505 NA 0.98 12.41 0.56 2.86e-29 Eosinophil percentage of granulocytes; CRC cis rs9796 0.621 rs557864 chr15:41471358 T/C cg18705301 chr15:41695430 NDUFAF1 0.42 6.89 0.36 2.89e-11 Menopause (age at onset); CRC trans rs2727020 0.729 rs10839268 chr11:49380328 G/A cg03929089 chr4:120376271 NA -0.83 -14.64 -0.63 1.03e-37 Coronary artery disease; CRC cis rs2535633 0.631 rs2245424 chr3:53003021 G/C cg15147215 chr3:52552868 STAB1 0.46 7.67 0.39 2.02e-13 Body mass index; CRC cis rs9354308 0.866 rs2802054 chr6:66544766 G/C cg07460842 chr6:66804631 NA 0.46 5.68 0.3 2.95e-8 Metabolite levels; CRC cis rs7523050 0.643 rs12752417 chr1:109400639 A/C cg08274380 chr1:109419600 GPSM2 -0.88 -6.61 -0.34 1.51e-10 Fat distribution (HIV); CRC cis rs2084637 1.000 rs11218651 chr11:122384336 A/C cg21585512 chr11:122030076 LOC399959 0.36 6.45 0.33 4.05e-10 Stroke; CRC cis rs10256972 0.621 rs10951594 chr7:1088607 C/G cg07308232 chr7:1071921 C7orf50 -0.47 -6.75 -0.35 6.89e-11 Longevity;Endometriosis; CRC cis rs6952808 0.595 rs3778983 chr7:2166319 T/G cg02951883 chr7:2050386 MAD1L1 -0.69 -11.03 -0.52 2.84e-24 Bipolar disorder and schizophrenia; CRC cis rs28386778 0.830 rs6504180 chr17:61813169 T/C cg06601766 chr17:61851465 DDX42;CCDC47 0.43 5.92 0.31 7.99e-9 Prudent dietary pattern; CRC cis rs7772486 0.558 rs7753273 chr6:146066039 C/T cg23711669 chr6:146136114 FBXO30 -0.63 -9.22 -0.45 3.73e-18 Lobe attachment (rater-scored or self-reported); CRC cis rs1538970 0.962 rs2185549 chr1:45814103 C/T cg05343316 chr1:45956843 TESK2 -0.69 -9.34 -0.46 1.49e-18 Platelet count; CRC cis rs73206853 0.534 rs13313211 chr12:110509616 A/T cg12870014 chr12:110450643 ANKRD13A 0.86 8.88 0.44 4.53e-17 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC cis rs698833 0.886 rs698766 chr2:44574277 C/G cg04920474 chr2:44395004 PPM1B 0.42 6.3 0.33 9.57e-10 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; CRC cis rs6951245 0.529 rs10262070 chr7:1141738 C/T cg04025307 chr7:1156635 C7orf50 0.67 8.47 0.42 8.36e-16 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC trans rs1005277 0.540 rs1814077 chr10:37992018 G/C cg27523141 chr10:43048294 ZNF37B 0.44 6.35 0.33 7.32e-10 Extrinsic epigenetic age acceleration; CRC cis rs1218582 0.741 rs6656494 chr1:154839799 A/G cg09359103 chr1:154839909 KCNN3 -0.78 -14.8 -0.63 2.51e-38 Prostate cancer; CRC trans rs1351696 1 rs1351696 chr11:48382471 A/G cg15704280 chr7:45808275 SEPT13 -0.64 -6.27 -0.33 1.12e-9 D-dimer levels; CRC cis rs7781557 1.000 rs7781557 chr7:102481891 A/G cg18108683 chr7:102477205 FBXL13 0.55 6.9 0.36 2.68e-11 Colorectal adenoma (advanced); CRC cis rs10883723 0.738 rs3781290 chr10:104244948 G/C cg11453585 chr10:104263688 ACTR1A;SUFU 0.9 16.29 0.67 3.54e-44 Allergic disease (asthma, hay fever or eczema); CRC cis rs7412746 0.658 rs72704652 chr1:150819470 A/G cg15448220 chr1:150897856 SETDB1 0.55 7.79 0.39 8.97e-14 Melanoma; CRC cis rs6840360 1.000 rs28637056 chr4:152652501 A/G cg09659197 chr4:152720779 NA 0.53 11.67 0.54 1.49e-26 Intelligence (multi-trait analysis); CRC cis rs6674176 0.628 rs2301993 chr1:44426025 G/A cg15962314 chr1:44399869 ARTN 0.3 5.85 0.31 1.18e-8 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Cognitive ability; CRC cis rs6089584 0.850 rs6089634 chr20:60632566 T/C cg23262073 chr20:60523788 NA -0.49 -7.69 -0.39 1.73e-13 Body mass index; CRC cis rs7914558 1.000 rs7914558 chr10:104775908 G/A cg04362960 chr10:104952993 NT5C2 0.6 9.07 0.45 1.13e-17 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs9916302 0.660 rs4795367 chr17:37608843 G/C cg00129232 chr17:37814104 STARD3 -0.58 -7.26 -0.37 2.74e-12 Glomerular filtration rate (creatinine); CRC cis rs9640161 0.871 rs56156367 chr7:150047201 A/T cg27494647 chr7:150038898 RARRES2 0.36 5.62 0.3 4.05e-8 Blood protein levels;Circulating chemerin levels; CRC cis rs3859192 0.577 rs25645 chr17:38173143 G/A cg17344932 chr17:38183730 MED24;SNORD124 0.86 16.78 0.68 4.17e-46 White blood cell count; CRC cis rs67478160 0.654 rs1535097 chr14:104216649 C/T cg01849466 chr14:104193079 ZFYVE21 -0.49 -8.74 -0.43 1.24e-16 Schizophrenia; CRC cis rs2516839 0.517 rs1556257 chr1:161051134 A/G cg11578532 chr1:161008127 TSTD1 0.28 5.76 0.3 1.94e-8 Granulocyte percentage of myeloid white cells; CRC cis rs13191362 1.000 rs13206253 chr6:163166902 A/G cg23758597 chr6:163146217 PARK2 -0.6 -6.71 -0.35 8.55e-11 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs853679 0.517 rs9380050 chr6:28048538 A/G cg02683197 chr6:28174875 NA 0.79 9.73 0.47 8.12e-20 Depression; CRC cis rs6701037 0.748 rs11583687 chr1:175132049 A/C cg14847009 chr1:175162515 KIAA0040 0.27 5.86 0.31 1.11e-8 Alcohol dependence; CRC cis rs4711350 0.734 rs7739273 chr6:33758065 G/A cg07979401 chr6:33739406 LEMD2 -0.46 -5.98 -0.31 5.7e-9 Schizophrenia; CRC cis rs8077889 0.672 rs15359 chr17:41843979 C/G cg16892393 chr17:41919603 NA -0.36 -5.72 -0.3 2.37e-8 Triglycerides; CRC cis rs6500395 1.000 rs1558816 chr16:48704868 T/A cg04672837 chr16:48644449 N4BP1 -0.45 -6.63 -0.34 1.38e-10 Response to tocilizumab in rheumatoid arthritis; CRC cis rs2180341 0.814 rs6569488 chr6:127726256 C/T cg27446573 chr6:127587934 RNF146 0.7 9.61 0.47 1.95e-19 Breast cancer; CRC cis rs1552244 0.515 rs111560858 chr3:10166845 G/A cg00166722 chr3:10149974 C3orf24 0.65 7.67 0.39 1.91e-13 Alzheimer's disease; CRC cis rs9649213 0.574 rs7794187 chr7:97889758 A/C cg21770322 chr7:97807741 LMTK2 0.59 9.85 0.48 3.14e-20 Prostate cancer (SNP x SNP interaction); CRC cis rs12451471 0.529 rs2278620 chr17:78083565 G/A cg24585782 chr17:78113791 EIF4A3 -0.53 -7.38 -0.38 1.3e-12 Plateletcrit;Mean corpuscular hemoglobin concentration; CRC trans rs1814175 0.817 rs6486044 chr11:49982718 C/T cg03929089 chr4:120376271 NA -0.94 -17.92 -0.7 1.32e-50 Height; CRC cis rs9914988 0.943 rs67327562 chr17:27108828 G/A cg20469991 chr17:27169893 C17orf63 -0.6 -7.26 -0.37 2.78e-12 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs12983728 0.536 rs34380569 chr19:58648528 A/G cg06882758 chr19:58662330 ZNF329 0.47 5.62 0.3 4.04e-8 Cholesterol, total; CRC cis rs7119 0.651 rs12905044 chr15:77846215 G/A cg10437265 chr15:77819839 NA 0.59 9.99 0.48 1.03e-20 Type 2 diabetes; CRC cis rs720844 0.507 rs4972377 chr2:149335154 T/C cg09247360 chr2:149335327 NA 0.48 6.28 0.33 1.08e-9 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs1448094 0.717 rs60713909 chr12:86294469 C/G cg19622623 chr12:86230825 RASSF9 -0.42 -6.76 -0.35 6.29e-11 Major depressive disorder; CRC cis rs7666738 0.830 rs13139078 chr4:99020774 C/T cg05340658 chr4:99064831 C4orf37 0.61 9.51 0.46 4.05e-19 Colonoscopy-negative controls vs population controls; CRC cis rs4819052 0.851 rs8127834 chr21:46696109 G/A cg11663144 chr21:46675770 NA -0.78 -12.94 -0.58 2.94e-31 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC trans rs561341 1.000 rs55736640 chr17:30333848 G/A cg20587970 chr11:113659929 NA -1.42 -20.09 -0.74 3.82e-59 Hip circumference adjusted for BMI; CRC cis rs9768139 1.000 rs9768139 chr7:158120731 G/A cg06219351 chr7:158114137 PTPRN2 0.44 6.57 0.34 2.03e-10 Calcium levels; CRC cis rs826838 1.000 rs10880963 chr12:38748408 T/C cg26384229 chr12:38710491 ALG10B 0.76 10.6 0.5 8.9e-23 Heart rate; CRC cis rs875971 0.862 rs937494 chr7:65764678 T/A cg18252515 chr7:66147081 NA 0.39 5.7 0.3 2.73e-8 Aortic root size; CRC trans rs561341 0.883 rs1034627 chr17:30219569 C/T cg27661571 chr11:113659931 NA -0.52 -6.25 -0.33 1.25e-9 Hip circumference adjusted for BMI; CRC cis rs7618915 0.571 rs2289249 chr3:52597664 G/A cg10802521 chr3:52805072 NEK4 -0.58 -9.01 -0.44 1.68e-17 Bipolar disorder; CRC cis rs11030122 0.661 rs12290747 chr11:3939650 T/C cg18678763 chr11:4115507 RRM1 -0.52 -8.41 -0.42 1.3e-15 Mean platelet volume;Platelet distribution width; CRC trans rs7604735 0.824 rs1830318 chr2:145819803 C/T cg26010734 chr19:15344046 EPHX3 0.36 6.2 0.32 1.73e-9 Coronary artery disease; CRC cis rs6772849 0.930 rs12630379 chr3:128370204 G/C cg08795948 chr3:128337044 NA 0.35 6.2 0.32 1.73e-9 Monocyte percentage of white cells;Monocyte count; CRC cis rs4253772 0.550 rs739164 chr22:46684558 C/T cg24881330 chr22:46731750 TRMU -0.69 -8.22 -0.41 4.62e-15 LDL cholesterol;Cholesterol, total; CRC cis rs79349575 0.715 rs9894220 chr17:46989154 C/T cg22482690 chr17:47019901 SNF8 0.43 6.98 0.36 1.67e-11 Type 2 diabetes; CRC trans rs9388451 0.626 rs1935983 chr6:126068914 C/T cg05039488 chr6:79577232 IRAK1BP1 -0.74 -12.93 -0.58 3.26e-31 Brugada syndrome; CRC cis rs3768617 0.510 rs12078729 chr1:183060072 T/A ch.1.3577855R chr1:183094577 LAMC1 0.87 15.3 0.64 2.79e-40 Fuchs's corneal dystrophy; CRC cis rs7586879 0.616 rs6726199 chr2:25126328 G/C cg22495460 chr2:25135724 ADCY3 -0.87 -16.95 -0.68 9.6e-47 Body mass index; CRC cis rs2120019 0.938 rs8028632 chr15:75321262 T/C cg17294928 chr15:75287854 SCAMP5 -0.77 -11.15 -0.52 1.03e-24 Blood trace element (Zn levels); CRC cis rs933688 1.000 rs2367526 chr5:90740525 A/G cg26981201 chr5:90679533 LOC100129716;ARRDC3 0.98 15.01 0.64 3.59e-39 Smoking behavior; CRC cis rs67311347 1.000 rs7617989 chr3:40512463 A/G cg24209194 chr3:40518798 ZNF619 -0.45 -6.92 -0.36 2.43e-11 Renal cell carcinoma; CRC cis rs35306767 0.903 rs12249828 chr10:894838 C/T cg26597838 chr10:835615 NA 0.86 10.71 0.51 3.67e-23 Eosinophil percentage of granulocytes; CRC cis rs7762018 1.000 rs73242927 chr6:170129573 T/A cg19338460 chr6:170058176 WDR27 -0.67 -7.38 -0.38 1.32e-12 Thiazide-induced adverse metabolic effects in hypertensive patients; CRC cis rs11212617 0.967 rs664982 chr11:108225483 C/T cg01991180 chr11:108092276 ATM;NPAT 0.44 6.56 0.34 2.08e-10 Response to metformin in type 2 diabetes (glycemic); CRC trans rs6561151 0.957 rs9316058 chr13:44485076 G/C cg12856521 chr11:46389249 DGKZ 0.63 9.51 0.46 4.18e-19 Crohn's disease; CRC trans rs11098499 0.691 rs28396837 chr4:120271541 G/A cg25214090 chr10:38739885 LOC399744 0.53 8.51 0.42 6.28e-16 Corneal astigmatism; CRC cis rs17345786 0.798 rs4257518 chr3:101281709 C/T cg03837452 chr3:101395095 ZBTB11;LOC100009676 -0.47 -5.77 -0.3 1.87e-8 Colonoscopy-negative controls vs population controls; CRC cis rs2898681 0.519 rs6848200 chr4:53730181 A/G cg21521518 chr4:53727714 RASL11B 0.41 6.07 0.32 3.56e-9 Optic nerve measurement (cup area); CRC cis rs73591976 0.540 rs55757502 chr16:68228427 C/T cg26727032 chr16:67993705 SLC12A4 -0.49 -5.73 -0.3 2.31e-8 HDL cholesterol; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg04633058 chr17:48474099 LRRC59 0.41 6.05 0.32 3.84e-9 Response to antipsychotic treatment; CRC cis rs34779708 0.931 rs12768019 chr10:35389843 T/C cg03585969 chr10:35415529 CREM 0.67 8.87 0.44 4.78e-17 Inflammatory bowel disease;Crohn's disease; CRC cis rs8102732 1.000 rs8102732 chr19:1023867 C/G cg13770691 chr19:1021866 C19orf6 0.42 6.78 0.35 5.63e-11 Eosinophil percentage of granulocytes; CRC cis rs7542091 0.669 rs7540534 chr1:210044824 A/T cg05527609 chr1:210001259 C1orf107 -0.44 -5.86 -0.31 1.15e-8 Monobrow; CRC cis rs7659604 1.000 rs7689722 chr4:122665955 T/C cg20573242 chr4:122745356 CCNA2 0.43 6.47 0.34 3.46e-10 Type 2 diabetes; CRC cis rs1448094 1.000 rs4919776 chr12:86353763 T/C cg18827107 chr12:86230957 RASSF9 -0.38 -6.22 -0.32 1.48e-9 Major depressive disorder; CRC cis rs887829 0.569 rs3755319 chr2:234667582 A/C cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.45 -7.21 -0.37 3.79e-12 Metabolic traits;Bilirubin levels;Cholelithiasis-related traits in sickle cell anemia;Metabolite levels;Total bilirubin levels in HIV-1 infection;Serum metabolite levels;Blood metabolite levels; CRC cis rs9487051 0.837 rs1915834 chr6:109597624 C/A cg12927641 chr6:109611667 NA -0.37 -6.61 -0.34 1.58e-10 Reticulocyte fraction of red cells; CRC cis rs13191362 0.935 rs34347104 chr6:163055716 C/T cg14584255 chr6:163149320 PACRG;PARK2 0.43 6.06 0.32 3.82e-9 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs4713118 0.824 rs742046 chr6:27739254 A/G cg03623178 chr6:28175578 NA 0.71 9.48 0.46 5.31e-19 Parkinson's disease; CRC cis rs651907 0.557 rs7651404 chr3:101393294 C/A cg12386194 chr3:101231763 SENP7 0.49 7.11 0.36 7.34e-12 Colorectal cancer; CRC trans rs1005277 0.505 rs7069702 chr10:38247359 G/T cg17830980 chr10:43048298 ZNF37B 0.41 6.35 0.33 7.09e-10 Extrinsic epigenetic age acceleration; CRC cis rs12476592 0.571 rs262517 chr2:63891261 G/T cg10828910 chr2:63850056 LOC388955 0.5 6.26 0.33 1.23e-9 Childhood ear infection; CRC cis rs4664293 0.647 rs10192408 chr2:160424594 G/T cg08347373 chr2:160653686 CD302 -0.39 -6.59 -0.34 1.76e-10 Monocyte percentage of white cells; CRC cis rs4237845 0.611 rs11172387 chr12:58332351 C/G cg02175503 chr12:58329896 NA 0.78 12.46 0.57 1.9e-29 Intelligence (multi-trait analysis); CRC trans rs2243480 1.000 rs1392104 chr7:65759107 G/A cg10756647 chr7:56101905 PSPH -0.77 -7.87 -0.4 5.06e-14 Diabetic kidney disease; CRC trans rs9858542 0.953 rs9853683 chr3:49512588 A/G cg21659725 chr3:3221576 CRBN -0.66 -8.98 -0.44 2.18e-17 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs2070488 1.000 rs17733640 chr3:38446742 G/A cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.9 16.19 0.67 8.88e-44 Electrocardiographic conduction measures; CRC cis rs1448094 0.773 rs11117100 chr12:86310392 A/G cg19622623 chr12:86230825 RASSF9 -0.41 -6.7 -0.35 9.12e-11 Major depressive disorder; CRC cis rs7223966 1.000 rs11079508 chr17:61750066 T/C cg05941027 chr17:61774174 LIMD2 0.36 6.61 0.34 1.54e-10 Hip circumference adjusted for BMI;Body mass index; CRC cis rs6582630 0.555 rs11610015 chr12:38508856 A/G cg13010199 chr12:38710504 ALG10B 0.47 6.44 0.33 4.34e-10 Drug-induced liver injury (flucloxacillin); CRC cis rs9359856 0.564 rs72913921 chr6:90328692 A/T cg13799429 chr6:90582589 CASP8AP2 -0.73 -7.62 -0.39 2.76e-13 Bipolar disorder; CRC cis rs270601 0.913 rs273899 chr5:131695178 G/A cg20512303 chr5:131592959 PDLIM4 0.38 6.56 0.34 2.09e-10 Acylcarnitine levels; CRC cis rs1552244 0.688 rs7645137 chr3:10020549 A/AT cg10729496 chr3:10149963 C3orf24 0.5 6.43 0.33 4.41e-10 Alzheimer's disease; CRC cis rs1957429 0.808 rs7144718 chr14:65333831 G/A cg23373153 chr14:65346875 NA 0.67 6.82 0.35 4.47e-11 Pediatric areal bone mineral density (radius); CRC cis rs60871478 0.945 rs62432254 chr7:804175 C/T cg05535760 chr7:792225 HEATR2 0.8 10.57 0.5 1.09e-22 Cerebrospinal P-tau181p levels; CRC cis rs7103648 0.966 rs10769263 chr11:47417183 A/C cg20307385 chr11:47447363 PSMC3 0.97 17.8 0.7 4.16e-50 Diastolic blood pressure;Systolic blood pressure; CRC cis rs7589728 0.563 rs4972044 chr2:88466196 T/C cg14558114 chr2:88469736 THNSL2 0.59 6.0 0.31 5.24e-9 Plasma clusterin levels; CRC cis rs243505 0.624 rs6975291 chr7:148548393 C/G cg09806900 chr7:148480153 CUL1 0.52 6.65 0.34 1.22e-10 Inflammatory bowel disease;Crohn's disease; CRC cis rs17376456 0.825 rs10072232 chr5:93398890 G/A cg21475434 chr5:93447410 FAM172A 0.74 7.56 0.38 4.17e-13 Diabetic retinopathy; CRC cis rs7618501 0.633 rs55751738 chr3:49972101 A/G cg24308560 chr3:49941425 MST1R -0.52 -8.75 -0.43 1.11e-16 Intelligence (multi-trait analysis); CRC trans rs7615952 0.546 rs2979338 chr3:125343126 G/T cg02560186 chr11:3602584 NA -0.56 -6.98 -0.36 1.63e-11 Blood pressure (smoking interaction); CRC cis rs8010715 0.816 rs8015168 chr14:24599872 A/T cg23112188 chr14:24563095 PCK2 -0.37 -7.24 -0.37 3.17e-12 IgG glycosylation; CRC cis rs2882667 0.690 rs288029 chr5:138217305 A/G cg09476006 chr5:138032270 NA 0.53 8.73 0.43 1.34e-16 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs902774 0.818 rs73110464 chr12:53312612 C/T cg14581129 chr12:53358946 NA -0.5 -5.82 -0.31 1.43e-8 Prostate cancer; CRC cis rs10499694 0.933 rs11575352 chr7:50594982 A/G cg18232548 chr7:50535776 DDC -0.41 -6.2 -0.32 1.67e-9 Body mass index; CRC cis rs875971 1.000 rs6460296 chr7:65895139 C/T cg12463550 chr7:65579703 CRCP 0.48 6.78 0.35 5.54e-11 Aortic root size; CRC cis rs10849893 0.576 rs7296507 chr12:121847135 A/G cg01154721 chr12:121881891 KDM2B -0.42 -6.1 -0.32 3.02e-9 Fasting blood glucose;Fasting blood glucose (BMI interaction); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg11427898 chr15:38544983 SPRED1 0.4 7.32 0.37 1.95e-12 Liver disease severity in Alagille syndrome; CRC cis rs11252926 0.510 rs4881371 chr10:554514 G/A cg03684893 chr10:554711 DIP2C -0.47 -8.26 -0.41 3.62e-15 Psychosis in Alzheimer's disease; CRC cis rs10504229 0.728 rs17215851 chr8:58154160 A/C cg08219700 chr8:58056026 NA 0.45 5.74 0.3 2.11e-8 Developmental language disorder (linguistic errors); CRC cis rs4727027 0.868 rs10952799 chr7:148840772 C/T cg23583168 chr7:148888333 NA -0.92 -15.93 -0.66 9.45e-43 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC cis rs10791323 0.604 rs2723615 chr11:133704567 C/T cg06766960 chr11:133703094 NA -0.36 -5.96 -0.31 6.6e-9 Childhood ear infection; CRC cis rs4953076 0.613 rs11124981 chr2:44462133 A/T cg04920474 chr2:44395004 PPM1B 0.58 7.71 0.39 1.49e-13 Height; CRC cis rs9381040 0.655 rs6903444 chr6:41014220 C/T cg03644281 chr6:41068752 NFYA;LOC221442 0.45 6.33 0.33 8.02e-10 Alzheimer's disease (late onset); CRC trans rs9545047 0.716 rs2265377 chr13:79999620 G/A cg07061582 chr15:90234082 PEX11A;WDR93 -0.41 -5.97 -0.31 6.15e-9 Schizophrenia; CRC cis rs2310173 0.575 rs13022757 chr2:102613546 G/C cg20856504 chr2:102616538 IL1R2 0.41 6.69 0.35 9.34e-11 Ankylosing spondylitis;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined);Ulcerative colitis; CRC cis rs801193 0.967 rs1110414 chr7:66205582 A/G cg00343986 chr7:65444356 GUSB 0.49 7.26 0.37 2.87e-12 Aortic root size; CRC cis rs6810498 0.932 rs7676659 chr4:26057613 C/T cg12925881 chr4:26050407 NA 0.43 8.09 0.41 1.16e-14 Alcohol dependence; CRC cis rs6500602 0.701 rs11643057 chr16:4544505 C/T cg08645402 chr16:4508243 NA 0.57 9.38 0.46 1.08e-18 Schizophrenia; CRC cis rs2404602 1.000 rs12441433 chr15:76816015 G/A cg23625390 chr15:77176239 SCAPER 0.57 8.73 0.43 1.29e-16 Blood metabolite levels; CRC cis rs2243480 1.000 rs2420171 chr7:65637760 T/C cg18252515 chr7:66147081 NA 1.23 14.37 0.62 1.07e-36 Diabetic kidney disease; CRC cis rs6456156 0.742 rs6456157 chr6:167527818 C/A cg05540913 chr6:167530185 CCR6 -0.38 -6.99 -0.36 1.5e-11 Primary biliary cholangitis; CRC cis rs9814567 1.000 rs12637751 chr3:134266124 A/G cg06541857 chr3:134203789 ANAPC13;CEP63 0.39 5.74 0.3 2.15e-8 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC trans rs9341835 0.741 rs6929702 chr6:64144114 T/C cg13657004 chr13:50234944 EBPL -0.36 -6.1 -0.32 2.93e-9 Schizophrenia; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg16919356 chr7:150780878 TMUB1 0.56 7.55 0.38 4.35e-13 Thyroid stimulating hormone; CRC cis rs1816752 0.905 rs7400631 chr13:24990065 A/G cg02811702 chr13:24901961 NA 0.41 5.74 0.3 2.15e-8 Obesity-related traits; CRC cis rs523522 0.847 rs11065132 chr12:120908459 C/T cg27279351 chr12:120934652 DYNLL1 0.79 11.41 0.53 1.2e-25 High light scatter reticulocyte count; CRC cis rs28386778 0.863 rs2597633 chr17:61872871 T/C cg22520471 chr17:61851767 DDX42;CCDC47 0.75 11.69 0.54 1.18e-26 Prudent dietary pattern; CRC cis rs12701220 0.553 rs7782024 chr7:1157502 G/T cg00990874 chr7:1149470 C7orf50 -0.65 -8.34 -0.42 2.12e-15 Bronchopulmonary dysplasia; CRC cis rs12801636 0.739 rs12790427 chr11:65384727 C/T cg21033440 chr11:65409861 SIPA1 -0.44 -5.64 -0.3 3.69e-8 Coronary artery disease;HDL cholesterol;HDL cholesterol levels; CRC cis rs6088590 0.687 rs6088582 chr20:33286798 G/A cg08999081 chr20:33150536 PIGU 0.56 10.23 0.49 1.71e-21 Coronary artery disease; CRC cis rs11711311 0.868 rs13091621 chr3:113481977 A/G cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.51 -6.94 -0.36 2.06e-11 IgG glycosylation; CRC cis rs7589728 0.563 rs78685993 chr2:88447026 T/C cg24977027 chr2:88469347 THNSL2 0.64 7.72 0.39 1.37e-13 Plasma clusterin levels; CRC cis rs4713118 0.540 rs469227 chr6:27970705 A/C cg15786705 chr6:28176104 NA 0.64 9.23 0.45 3.27e-18 Parkinson's disease; CRC cis rs9905704 0.647 rs11650809 chr17:56972741 A/G cg12560992 chr17:57184187 TRIM37 0.61 9.21 0.45 3.95e-18 Testicular germ cell tumor; CRC cis rs6694672 1.000 rs1571964 chr1:197113073 G/A cg13682187 chr1:196946512 CFHR5 0.42 6.72 0.35 8.15e-11 Asthma; CRC cis rs11623869 0.614 rs11627052 chr14:103863476 A/G cg07514618 chr14:103979422 NA 0.45 6.9 0.36 2.73e-11 Bone mineral density; CRC cis rs6951245 0.554 rs78999139 chr7:1138525 G/A cg24642844 chr7:1081250 C7orf50 -0.48 -6.32 -0.33 8.53e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs2204008 0.583 rs12307593 chr12:38317803 A/G cg13010199 chr12:38710504 ALG10B 0.39 5.72 0.3 2.42e-8 Bladder cancer; CRC cis rs4862750 0.758 rs2375915 chr4:187896255 A/C cg03452623 chr4:187889614 NA -0.92 -21.7 -0.77 2.01e-65 Lobe attachment (rater-scored or self-reported); CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg04742505 chr7:72936528 BAZ1B -0.53 -6.45 -0.34 4.08e-10 Diisocyanate-induced asthma; CRC cis rs959260 0.623 rs2164244 chr17:73325244 C/T cg14668889 chr17:73230827 NUP85 -0.51 -7.53 -0.38 4.81e-13 Systemic lupus erythematosus; CRC cis rs2871473 1.000 rs2871473 chr2:103107280 A/C cg09003973 chr2:102972529 NA 0.48 6.29 0.33 9.94e-10 Blood protein levels; CRC cis rs7113874 0.589 rs2028882 chr11:8504854 A/C cg02811074 chr11:8615871 STK33 -0.36 -6.16 -0.32 2.08e-9 Body mass index in physically active individuals;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs172166 0.637 rs1225592 chr6:28150242 G/A cg26587870 chr6:27730563 NA -0.37 -5.76 -0.3 1.96e-8 Cardiac Troponin-T levels; CRC cis rs2404602 0.716 rs12594577 chr15:76828793 A/C cg22467129 chr15:76604101 ETFA -0.45 -7.49 -0.38 6.44e-13 Blood metabolite levels; CRC cis rs6543140 0.964 rs10196334 chr2:103090041 T/C cg04239558 chr2:103089729 SLC9A4 0.38 6.64 0.34 1.29e-10 Blood protein levels; CRC cis rs6973256 0.897 rs2345941 chr7:133337635 C/T cg10665199 chr7:133106180 EXOC4 0.38 5.87 0.31 1.09e-8 Intelligence (multi-trait analysis); CRC cis rs1941023 0.503 rs2233238 chr11:60145441 G/C cg08716584 chr11:60157161 MS4A7 -0.55 -9.12 -0.45 7.42e-18 Congenital heart disease (maternal effect); CRC cis rs9733 0.566 rs878471 chr1:150547747 G/A cg17724175 chr1:150552817 MCL1 -0.54 -9.28 -0.46 2.39e-18 Tonsillectomy; CRC cis rs875971 0.862 rs6962717 chr7:65883735 G/A cg12463550 chr7:65579703 CRCP 0.5 6.98 0.36 1.65e-11 Aortic root size; CRC cis rs9325144 0.555 rs7960411 chr12:38703019 A/G cg26384229 chr12:38710491 ALG10B -0.57 -8.44 -0.42 1.04e-15 Morning vs. evening chronotype; CRC cis rs11931598 0.783 rs28661210 chr4:7050956 C/A cg26116260 chr4:7069785 GRPEL1 0.56 8.33 0.42 2.14e-15 Sum basophil neutrophil counts;Sum neutrophil eosinophil counts;Granulocyte count;Neutrophil count;Myeloid white cell count; CRC cis rs4930103 0.935 rs2075745 chr11:2018336 A/T cg06197492 chr11:2016605 H19 0.41 6.38 0.33 6.15e-10 DNA methylation (parent-of-origin);DNA methylation (variation); CRC cis rs2836974 0.965 rs2836967 chr21:40639102 T/G cg17971929 chr21:40555470 PSMG1 0.83 11.91 0.55 1.9e-27 Cognitive function; CRC cis rs9341808 0.935 rs4706113 chr6:80839315 C/T cg08355045 chr6:80787529 NA 0.36 6.02 0.31 4.74e-9 Sitting height ratio; CRC cis rs7043114 0.525 rs2274966 chr9:95155563 C/A cg13798575 chr9:95087839 CENPP;NOL8 -0.4 -5.98 -0.31 5.7e-9 Height; CRC cis rs9303401 0.659 rs62083436 chr17:57031742 G/A cg10487724 chr17:56770010 TEX14;RAD51C 0.79 9.87 0.48 2.61e-20 Cognitive test performance; CRC cis rs9325144 0.534 rs1973293 chr12:38679575 C/T cg26384229 chr12:38710491 ALG10B 0.54 7.74 0.39 1.21e-13 Morning vs. evening chronotype; CRC cis rs4665809 1.000 rs4665820 chr2:26309150 T/C cg27170947 chr2:26402098 FAM59B -0.45 -6.06 -0.32 3.68e-9 Gut microbiome composition (summer); CRC cis rs524281 0.773 rs2155031 chr11:66030927 C/T cg16950941 chr11:66035639 RAB1B -0.72 -8.16 -0.41 7.42e-15 Electroencephalogram traits; CRC trans rs2303319 0.504 rs35304298 chr2:162617185 G/T cg11326919 chr17:43324904 LOC100133991 -0.64 -5.99 -0.31 5.65e-9 Cognitive function; CRC cis rs9527 0.569 rs10786730 chr10:104724200 G/A cg04362960 chr10:104952993 NT5C2 0.59 8.42 0.42 1.21e-15 Arsenic metabolism; CRC trans rs7615952 0.512 rs4234285 chr3:125404477 G/A cg21747405 chr11:67723411 NA -0.55 -8.7 -0.43 1.61e-16 Blood pressure (smoking interaction); CRC cis rs11078597 0.731 rs4790285 chr17:1651697 C/T cg18436246 chr17:1640651 WDR81 -0.7 -10.27 -0.49 1.16e-21 Serum albumin level; CRC cis rs7605827 0.930 rs12993042 chr2:15708218 A/T cg19274914 chr2:15703543 NA 0.37 5.76 0.3 1.96e-8 Educational attainment (years of education); CRC cis rs4077468 0.963 rs4951271 chr1:205913848 A/G cg13172432 chr1:205912842 SLC26A9 -0.33 -5.71 -0.3 2.55e-8 Cystic fibrosis-related diabetes; CRC cis rs7618915 0.501 rs2079929 chr3:52765646 C/T cg10802521 chr3:52805072 NEK4 -0.57 -8.87 -0.44 4.63e-17 Bipolar disorder; CRC cis rs4665809 1.000 rs6546726 chr2:26275116 A/G cg22920501 chr2:26401640 FAM59B -0.52 -7.16 -0.37 5.45e-12 Gut microbiome composition (summer); CRC cis rs780096 0.545 rs6716894 chr2:27583273 A/G cg24768116 chr2:27665128 KRTCAP3 -0.31 -6.85 -0.35 3.57e-11 Total body bone mineral density; CRC cis rs2730245 1.000 rs2730241 chr7:158723014 T/C cg24397884 chr7:158709396 WDR60 -0.96 -16.33 -0.67 2.45e-44 Height; CRC cis rs782590 0.935 rs62165197 chr2:55801812 C/T cg18811423 chr2:55921094 PNPT1 0.79 14.73 0.63 4.46e-38 Metabolic syndrome; CRC cis rs10392 0.543 rs1733 chr20:37581506 G/A cg27552599 chr20:37590471 DHX35 0.37 5.81 0.3 1.5e-8 Alcohol dependence or chronic alcoholic pancreatitis or alcohol-related liver cirrhosis; CRC cis rs10256972 0.524 rs6945202 chr7:1116558 T/C cg27094323 chr7:1216898 NA -0.36 -5.91 -0.31 8.37e-9 Longevity;Endometriosis; CRC cis rs10504229 0.683 rs72650847 chr8:58136825 C/T cg02725872 chr8:58115012 NA -0.57 -8.0 -0.4 2.17e-14 Developmental language disorder (linguistic errors); CRC cis rs910316 0.967 rs8007539 chr14:75664953 T/C cg11812906 chr14:75593930 NEK9 -0.52 -8.1 -0.41 1.09e-14 Height; CRC trans rs10983614 1.000 rs7867776 chr9:120072627 A/G cg10516465 chr14:102695515 RAGE 0.46 6.52 0.34 2.72e-10 Survival in pancreatic cancer; CRC cis rs6988636 1.000 rs57165742 chr8:124184559 G/A cg27053337 chr8:124217698 FAM83A 0.45 6.81 0.35 4.55e-11 Urinary uromodulin levels; CRC cis rs9807989 0.507 rs1420097 chr2:103009354 C/G cg03938978 chr2:103052716 IL18RAP -0.6 -10.51 -0.5 1.76e-22 Asthma; CRC cis rs1552244 0.882 rs3755782 chr3:10029305 T/C cg16606324 chr3:10149918 C3orf24 0.61 7.98 0.4 2.47e-14 Alzheimer's disease; CRC cis rs933688 0.938 rs1477348 chr5:90707823 G/A cg02339078 chr5:90679543 LOC100129716;ARRDC3 0.92 13.87 0.61 9.28e-35 Smoking behavior; CRC cis rs7503807 0.967 rs12949279 chr17:78558411 T/C cg09596252 chr17:78655493 RPTOR 0.39 5.98 0.31 5.82e-9 Obesity; CRC cis rs10504229 0.774 rs72650880 chr8:58164727 C/T cg20607798 chr8:58055168 NA 0.52 6.17 0.32 1.98e-9 Developmental language disorder (linguistic errors); CRC cis rs2204008 0.627 rs1851117 chr12:38398987 G/T cg26384229 chr12:38710491 ALG10B 0.7 9.81 0.48 4.41e-20 Bladder cancer; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg15555727 chr8:144692268 PYCRL 0.46 6.59 0.34 1.76e-10 Response to antipsychotic treatment; CRC cis rs9311676 0.656 rs66793022 chr3:58391565 C/T cg06643156 chr3:58380774 PXK 0.41 6.33 0.33 7.82e-10 Systemic lupus erythematosus; CRC cis rs881375 0.967 rs1008381 chr9:123681116 T/C cg00246817 chr9:123691163 NA -0.44 -5.62 -0.3 4.08e-8 Rheumatoid arthritis; CRC cis rs736408 0.660 rs2019065 chr3:52809525 C/T cg18099408 chr3:52552593 STAB1 0.44 7.41 0.38 1.07e-12 Bipolar disorder; CRC cis rs2549003 0.870 rs61175929 chr5:131821548 C/G cg02551604 chr5:131831745 NA -0.54 -8.34 -0.42 2e-15 Asthma (sex interaction); CRC cis rs57994353 1.000 rs57994353 chr9:139356987 T/C cg14364472 chr9:139394549 NOTCH1 -0.44 -6.3 -0.33 9.78e-10 Eosinophil counts;Cutaneous squamous cell carcinoma; CRC cis rs3823572 0.503 rs4731990 chr7:133689074 C/T cg03336402 chr7:133662267 EXOC4 -0.66 -9.66 -0.47 1.38e-19 Intelligence (multi-trait analysis); CRC cis rs10782582 0.609 rs76260657 chr1:76338017 C/T cg10523679 chr1:76189770 ACADM -0.41 -5.71 -0.3 2.54e-8 Daytime sleep phenotypes; CRC cis rs8077889 0.917 rs1859048 chr17:41892039 A/C cg26893861 chr17:41843967 DUSP3 -0.88 -12.11 -0.56 3.55e-28 Triglycerides; CRC cis rs5769765 0.862 rs138857 chr22:50199589 C/T cg02269571 chr22:50332266 NA -0.64 -8.62 -0.43 2.89e-16 Schizophrenia; CRC trans rs17783634 0.509 rs11775489 chr8:11036843 T/C cg06636001 chr8:8085503 FLJ10661 -0.46 -6.7 -0.35 9.24e-11 Subjective well-being; CRC cis rs6424115 0.729 rs586173 chr1:24055718 A/G cg10978503 chr1:24200527 CNR2 -0.45 -7.5 -0.38 5.98e-13 Immature fraction of reticulocytes; CRC cis rs1448094 0.511 rs34656916 chr12:86154658 G/C cg00310523 chr12:86230176 RASSF9 0.41 6.62 0.34 1.5e-10 Major depressive disorder; CRC cis rs2243480 1.000 rs4718333 chr7:65772758 T/C cg25985355 chr7:65971099 NA 0.51 5.79 0.3 1.6e-8 Diabetic kidney disease; CRC cis rs1552244 0.935 rs2272124 chr3:10138189 T/C cg13047869 chr3:10149882 C3orf24 0.51 7.34 0.38 1.68e-12 Alzheimer's disease; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg27362927 chr21:43299497 PRDM15 0.44 6.1 0.32 2.9e-9 Anxiety disorder; CRC cis rs4713118 0.662 rs464312 chr6:27967591 T/A cg21251018 chr6:28226885 NKAPL 0.45 6.89 0.36 2.83e-11 Parkinson's disease; CRC cis rs10791097 1.000 rs10791097 chr11:130718630 G/T cg12179176 chr11:130786555 SNX19 -0.56 -8.5 -0.42 6.78e-16 Autism spectrum disorder or schizophrenia;Schizophrenia; CRC cis rs909002 0.759 rs10914454 chr1:32078940 G/A cg01639898 chr1:32083012 HCRTR1 0.31 6.4 0.33 5.33e-10 Intelligence (multi-trait analysis); CRC cis rs2204008 0.806 rs7305409 chr12:38349133 G/A cg26384229 chr12:38710491 ALG10B 0.69 9.24 0.45 3.04e-18 Bladder cancer; CRC trans rs6733379 0.588 rs2193790 chr2:34445953 A/G cg03181118 chr3:128483840 RAB7A -0.46 -6.7 -0.35 9.01e-11 Attention deficit hyperactivity disorder and conduct disorder; CRC trans rs7267979 1.000 rs2257985 chr20:25269743 G/T cg17903999 chr18:56338584 MALT1 -0.41 -6.89 -0.36 2.82e-11 Liver enzyme levels (alkaline phosphatase); CRC cis rs514406 0.929 rs1242224 chr1:53314887 G/A cg24675658 chr1:53192096 ZYG11B -0.56 -8.38 -0.42 1.57e-15 Monocyte count; CRC trans rs61931739 0.500 rs10844846 chr12:34394611 C/G cg13010199 chr12:38710504 ALG10B 0.44 6.33 0.33 8.16e-10 Morning vs. evening chronotype; CRC trans rs1728785 0.901 rs12929568 chr16:68596689 A/G cg04657470 chr2:198365150 HSPE1;HSPD1 0.67 8.46 0.42 8.72e-16 Ulcerative colitis; CRC cis rs57221529 0.766 rs56216231 chr5:581193 G/A cg09021430 chr5:549028 NA -0.72 -7.9 -0.4 4.17e-14 Lung disease severity in cystic fibrosis; CRC trans rs6600671 1.000 rs2319969 chr1:121207335 A/G cg00646200 chr1:148855367 NA 0.34 6.03 0.32 4.48e-9 Hip geometry; CRC cis rs6973256 0.604 rs6975134 chr7:133531432 T/C cg10665199 chr7:133106180 EXOC4 0.45 6.84 0.35 3.79e-11 Intelligence (multi-trait analysis); CRC cis rs6860806 0.695 rs6867282 chr5:131583120 G/C cg04518342 chr5:131593106 PDLIM4 0.47 8.6 0.43 3.41e-16 Breast cancer; CRC cis rs7666738 0.830 rs13113899 chr4:99050422 T/C cg17366294 chr4:99064904 C4orf37 0.44 7.43 0.38 9.25e-13 Colonoscopy-negative controls vs population controls; CRC cis rs853679 0.569 rs9348798 chr6:28143011 G/A cg02631126 chr6:28058918 ZSCAN12L1 0.29 5.73 0.3 2.26e-8 Depression; CRC cis rs939658 0.805 rs35832166 chr15:79417994 G/T cg17916960 chr15:79447300 NA -0.45 -7.3 -0.37 2.2e-12 Refractive error; CRC cis rs1150668 0.796 rs728122 chr6:28399124 G/A cg21251018 chr6:28226885 NKAPL 0.48 8.26 0.41 3.67e-15 Pubertal anthropometrics; CRC cis rs75804782 0.641 rs60841092 chr2:239349640 G/A cg18131467 chr2:239335373 ASB1 -0.73 -6.26 -0.33 1.18e-9 Morning vs. evening chronotype;Chronotype; CRC cis rs427941 0.632 rs201526 chr7:101774333 T/G cg06246474 chr7:101738831 CUX1 0.45 6.95 0.36 1.98e-11 Plasma omega-3 polyunsaturated fatty acid level (eicosapentaenoic acid); CRC cis rs7945705 0.935 rs2568062 chr11:8887945 A/G cg14711859 chr11:8959438 ASCL3 0.45 7.53 0.38 4.98e-13 Hemoglobin concentration; CRC cis rs807669 0.565 rs5746682 chr22:19185526 C/T cg02655711 chr22:19163373 SLC25A1 0.81 14.77 0.63 3.22e-38 Metabolite levels; CRC cis rs12701220 0.655 rs10241018 chr7:1144774 G/C cg26240231 chr7:1148101 C7orf50 -0.46 -6.7 -0.35 8.85e-11 Bronchopulmonary dysplasia; CRC cis rs3785574 0.962 rs56295011 chr17:61850359 A/G cg23090583 chr17:61904693 PSMC5;FTSJ3 0.65 9.52 0.46 3.78e-19 Height; CRC trans rs2303319 0.504 rs56009150 chr2:162598582 T/C cg10272801 chr16:14013773 ERCC4 -0.69 -6.16 -0.32 2.15e-9 Cognitive function; CRC cis rs9467773 0.620 rs2504567 chr6:26662920 C/G cg09904177 chr6:26538194 HMGN4 0.74 11.76 0.54 6.75e-27 Intelligence (multi-trait analysis); CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg02603434 chr19:49122389 RPL18;SPHK2 0.48 6.6 0.34 1.63e-10 Anxiety disorder; CRC cis rs875971 0.862 rs6460302 chr7:65960257 C/G cg18876405 chr7:65276391 NA 0.51 8.36 0.42 1.74e-15 Aortic root size; CRC cis rs6066835 1.000 rs6095270 chr20:47356062 T/C cg18078177 chr20:47281410 PREX1 0.64 6.0 0.31 5.07e-9 Multiple myeloma; CRC cis rs72627123 0.867 rs73303113 chr14:74481068 A/G cg12022184 chr14:74485813 ENTPD5;C14orf45 0.71 5.81 0.3 1.5e-8 Morning vs. evening chronotype; CRC cis rs2836974 0.897 rs2836929 chr21:40543811 T/C cg11890956 chr21:40555474 PSMG1 1.08 18.6 0.72 2.69e-53 Cognitive function; CRC cis rs2721195 0.967 rs1985022 chr8:145684031 C/T cg15857475 chr8:145742913 RECQL4;LRRC14 0.67 10.52 0.5 1.65e-22 Age at first birth; CRC cis rs7487075 0.619 rs7485580 chr12:46830374 A/C cg22049899 chr12:47219821 SLC38A4 0.31 5.74 0.3 2.12e-8 Itch intensity from mosquito bite; CRC cis rs561341 1.000 rs4795667 chr17:30244443 T/C cg12193833 chr17:30244370 NA -0.7 -8.35 -0.42 1.98e-15 Hip circumference adjusted for BMI; CRC cis rs6502050 0.805 rs11077970 chr17:80085916 C/T cg19223190 chr17:80058835 NA -0.4 -6.29 -0.33 1.03e-9 Life satisfaction; CRC cis rs1784581 0.588 rs6455790 chr6:162418447 C/T cg17173639 chr6:162384350 PARK2 -0.6 -9.71 -0.47 9.03e-20 Itch intensity from mosquito bite; CRC trans rs1656966 1.000 rs1656966 chr3:186466252 C/T cg21685266 chr3:184971652 EHHADH 0.39 6.02 0.31 4.63e-9 Myopia (pathological); CRC cis rs4774899 0.752 rs2962992 chr15:57346505 T/C cg08128148 chr15:57256372 TCF12 -0.39 -5.67 -0.3 3.19e-8 Urinary tract infection frequency; CRC trans rs6951245 0.572 rs75083636 chr7:1050800 C/T cg13565492 chr6:43139072 SRF -0.86 -6.34 -0.33 7.43e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs2252790 1.000 rs2498710 chr6:116670636 G/A cg18764771 chr6:116381957 FRK -0.22 -5.8 -0.3 1.59e-8 Fast beta electroencephalogram; CRC trans rs2797160 0.837 rs1739364 chr6:126022383 A/G cg05039488 chr6:79577232 IRAK1BP1 -0.52 -7.62 -0.39 2.71e-13 Endometrial cancer; CRC cis rs7666738 0.791 rs34790496 chr4:98930516 C/T cg05340658 chr4:99064831 C4orf37 0.57 8.73 0.43 1.35e-16 Colonoscopy-negative controls vs population controls; CRC cis rs7618915 0.547 rs13064064 chr3:52657002 T/C cg10802521 chr3:52805072 NEK4 -0.58 -8.98 -0.44 2.11e-17 Bipolar disorder; CRC trans rs7615952 0.641 rs12491577 chr3:125731131 C/T cg07211511 chr3:129823064 LOC729375 -0.79 -10.98 -0.52 4.05e-24 Blood pressure (smoking interaction); CRC cis rs826838 0.967 rs11169387 chr12:39145737 C/T cg13010199 chr12:38710504 ALG10B 0.43 5.6 0.3 4.46e-8 Heart rate; CRC cis rs524281 0.861 rs10896077 chr11:65851733 C/G cg16950941 chr11:66035639 RAB1B -0.61 -7.66 -0.39 2.13e-13 Electroencephalogram traits; CRC cis rs473651 1.000 rs473651 chr2:239335401 A/C cg08773314 chr2:239334832 ASB1 0.38 8.81 0.44 7.54e-17 Multiple system atrophy; CRC cis rs9768139 0.733 rs35016950 chr7:158118710 C/A cg25566285 chr7:158114605 PTPRN2 0.47 7.37 0.38 1.42e-12 Calcium levels; CRC cis rs896854 0.608 rs7004862 chr8:95876963 T/G cg16049864 chr8:95962084 TP53INP1 -0.57 -9.78 -0.47 5.21e-20 Type 2 diabetes; CRC cis rs6831352 0.734 rs1154400 chr4:100010010 C/T cg13256891 chr4:100009986 ADH5 0.57 7.92 0.4 3.7e-14 Alcohol dependence; CRC cis rs6502050 0.637 rs74765203 chr17:80118223 A/G cg02741985 chr17:80059408 CCDC57 0.43 7.11 0.36 7.24e-12 Life satisfaction; CRC cis rs10504229 1.000 rs6987435 chr8:58177334 G/A cg02725872 chr8:58115012 NA -0.4 -6.84 -0.35 3.79e-11 Developmental language disorder (linguistic errors); CRC cis rs1552244 1.000 rs722509 chr3:10102377 T/A cg13047869 chr3:10149882 C3orf24 0.57 7.8 0.4 8.27e-14 Alzheimer's disease; CRC cis rs116095464 0.558 rs10065584 chr5:253997 G/A cg22857025 chr5:266934 NA -1.16 -12.12 -0.56 3.3e-28 Breast cancer; CRC trans rs11098499 0.739 rs951570 chr4:120150467 T/C cg25214090 chr10:38739885 LOC399744 -0.42 -6.73 -0.35 7.39e-11 Corneal astigmatism; CRC cis rs9925964 0.967 rs14235 chr16:31121793 G/A cg03418659 chr16:31128414 MYST1 0.52 7.51 0.38 5.49e-13 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs875971 0.522 rs1968127 chr7:66056803 C/T cg11764359 chr7:65958608 NA -0.55 -8.65 -0.43 2.36e-16 Aortic root size; CRC cis rs294883 0.739 rs4709294 chr6:159730544 C/T cg14500486 chr6:159655392 FNDC1 0.37 6.43 0.33 4.45e-10 Coronary artery disease; CRC cis rs801193 0.967 rs34356500 chr7:66236607 G/T cg18876405 chr7:65276391 NA 0.57 10.13 0.49 3.69e-21 Aortic root size; CRC cis rs4731207 0.698 rs6956638 chr7:124530115 C/T cg23710748 chr7:124431027 NA -0.38 -6.06 -0.32 3.65e-9 Cutaneous malignant melanoma; CRC cis rs9308731 0.583 rs4848406 chr2:111933758 G/A cg04202892 chr2:111875749 ACOXL 0.39 6.13 0.32 2.52e-9 Chronic lymphocytic leukemia; CRC cis rs7394190 0.748 rs11000775 chr10:75539010 T/C cg07699608 chr10:75541558 CHCHD1 0.59 6.26 0.33 1.18e-9 Incident atrial fibrillation; CRC cis rs2180341 0.814 rs9401959 chr6:127736464 T/C cg27446573 chr6:127587934 RNF146 0.69 9.42 0.46 8.11e-19 Breast cancer; CRC cis rs1223397 0.938 rs3817738 chr6:13279388 G/T cg06879394 chr6:13274151 PHACTR1 0.57 6.49 0.34 3.21e-10 Blood pressure; CRC cis rs733175 0.855 rs6853437 chr4:10005435 A/G cg00071950 chr4:10020882 SLC2A9 -0.39 -5.62 -0.3 4.1e-8 Psychosis and Alzheimer's disease; CRC cis rs3823572 0.564 rs3735050 chr7:133682181 T/C cg03336402 chr7:133662267 EXOC4 -0.65 -9.53 -0.47 3.48e-19 Intelligence (multi-trait analysis); CRC cis rs11098499 0.698 rs4422403 chr4:120258194 C/T cg24375607 chr4:120327624 NA 0.47 7.62 0.39 2.78e-13 Corneal astigmatism; CRC cis rs9393692 0.572 rs4145878 chr6:26198046 A/T cg00631329 chr6:26305371 NA -0.5 -8.72 -0.43 1.42e-16 Educational attainment; CRC cis rs4332037 0.624 rs11764337 chr7:1892309 A/G cg21155852 chr7:2048760 MAD1L1 0.42 6.09 0.32 3.14e-9 Bipolar disorder; CRC cis rs7666738 0.830 rs1593572 chr4:98979322 A/G cg17366294 chr4:99064904 C4orf37 -0.43 -7.21 -0.37 3.83e-12 Colonoscopy-negative controls vs population controls; CRC cis rs7618501 0.521 rs2883059 chr3:49902160 C/T cg24308560 chr3:49941425 MST1R 0.45 6.84 0.35 3.9e-11 Intelligence (multi-trait analysis); CRC cis rs1008375 1.000 rs1008374 chr4:17683219 G/A cg16339924 chr4:17578868 LAP3 0.52 6.91 0.36 2.46e-11 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs7771547 0.573 rs546353 chr6:36398597 C/A cg04289385 chr6:36355825 ETV7 0.38 5.61 0.3 4.25e-8 Platelet distribution width; CRC cis rs6933660 0.666 rs9371516 chr6:151739642 G/A cg14416726 chr6:151773293 C6orf211;RMND1 -0.58 -8.84 -0.44 5.88e-17 Menarche (age at onset); CRC cis rs853679 0.517 rs67878650 chr6:28142587 G/C cg15845792 chr6:28175446 NA 1.04 13.81 0.61 1.6e-34 Depression; CRC cis rs7725052 0.609 rs4527650 chr5:40460205 T/C cg09067459 chr5:40385259 NA -0.4 -6.68 -0.35 9.91e-11 Pediatric autoimmune diseases; CRC cis rs17826219 0.706 rs609472 chr17:28951427 T/C cg14008862 chr17:28927542 LRRC37B2 0.51 6.03 0.32 4.44e-9 Body mass index; CRC cis rs9549328 0.611 rs72661939 chr13:113617498 C/T cg08614441 chr13:113633676 MCF2L 0.4 7.06 0.36 9.78e-12 Systolic blood pressure; CRC trans rs8002861 0.727 rs9525852 chr13:44405197 G/C cg12856521 chr11:46389249 DGKZ -0.5 -8.3 -0.42 2.64e-15 Leprosy; CRC cis rs9650657 0.513 rs7005884 chr8:10796472 A/G cg27411982 chr8:10470053 RP1L1 -0.41 -6.5 -0.34 3.06e-10 Neuroticism; CRC cis rs2072510 0.593 rs2540498 chr12:96400569 T/A cg22491680 chr12:96389547 HAL -0.47 -6.1 -0.32 2.9e-9 Metabolite levels (small molecules and protein measures); CRC cis rs4478858 0.735 rs4949205 chr1:31800579 A/G cg00250761 chr1:31883323 NA -0.44 -8.5 -0.42 6.71e-16 Alcohol dependence; CRC cis rs4713118 0.523 rs2179096 chr6:27665920 C/T cg06470822 chr6:28175283 NA 0.62 9.04 0.45 1.42e-17 Parkinson's disease; CRC cis rs10504229 0.683 rs6998040 chr8:58110155 G/T cg04204079 chr8:58130323 NA 0.44 5.61 0.3 4.39e-8 Developmental language disorder (linguistic errors); CRC cis rs853679 0.517 rs9368555 chr6:28108967 T/C cg12963246 chr6:28129442 ZNF389 0.49 5.7 0.3 2.71e-8 Depression; CRC cis rs6866344 0.570 rs11740283 chr5:178136440 T/C cg03877680 chr5:178157825 ZNF354A 0.75 10.7 0.51 3.93e-23 Neutrophil percentage of white cells; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg17417193 chr6:45983110 CLIC5 0.39 6.27 0.33 1.16e-9 Liver disease severity in Alagille syndrome; CRC cis rs2898681 0.567 rs77657787 chr4:53729981 G/A cg00791764 chr4:53727839 RASL11B 0.59 6.29 0.33 1.02e-9 Optic nerve measurement (cup area); CRC cis rs28386778 0.897 rs2236736 chr17:61938248 G/T cg11494091 chr17:61959527 GH2 0.59 9.93 0.48 1.66e-20 Prudent dietary pattern; CRC cis rs1552244 0.882 rs13084194 chr3:10031492 T/A cg02579736 chr3:10068473 FANCD2;CIDECP 0.93 11.04 0.52 2.63e-24 Alzheimer's disease; CRC cis rs58688157 0.705 rs7928902 chr11:609068 G/A cg03909863 chr11:638404 DRD4 -0.52 -6.89 -0.36 2.83e-11 Systemic lupus erythematosus; CRC cis rs11758351 1.000 rs77957229 chr6:26185226 A/G cg22723502 chr6:26240528 HIST1H4F -0.41 -6.33 -0.33 8.16e-10 Gout;Renal underexcretion gout; CRC cis rs72717009 0.756 rs10494359 chr1:161463876 G/C cg23840854 chr1:161414152 NA -0.67 -7.98 -0.4 2.48e-14 Rheumatoid arthritis; CRC cis rs2836974 0.644 rs719230 chr21:40676307 C/T cg11890956 chr21:40555474 PSMG1 -0.9 -15.54 -0.65 3.27e-41 Cognitive function; CRC cis rs6502050 0.799 rs8082355 chr17:80120316 A/G cg22110888 chr17:80059540 CCDC57 0.4 6.38 0.33 5.96e-10 Life satisfaction; CRC cis rs9469578 1.000 rs16869464 chr6:33715127 A/G cg18708504 chr6:33715942 IP6K3 0.66 7.56 0.38 4e-13 Phosphorus levels; CRC cis rs9902453 0.808 rs76039587 chr17:28233760 C/T cg26525008 chr17:28256777 EFCAB5;SSH2 0.57 8.56 0.43 4.53e-16 Coffee consumption (cups per day); CRC cis rs34779708 0.966 rs7077242 chr10:35481965 A/C cg03585969 chr10:35415529 CREM -0.55 -7.4 -0.38 1.17e-12 Inflammatory bowel disease;Crohn's disease; CRC trans rs1945213 0.694 rs12222077 chr11:55848116 T/A cg15704280 chr7:45808275 SEPT13 0.55 6.15 0.32 2.25e-9 Acute lymphoblastic leukemia (childhood); CRC cis rs4664293 0.625 rs35241460 chr2:160508200 T/A cg08347373 chr2:160653686 CD302 0.39 6.68 0.35 1.03e-10 Monocyte percentage of white cells; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg15072625 chr6:86302950 SNX14 0.56 8.24 0.41 4.25e-15 Response to antipsychotic treatment; CRC cis rs6502050 0.865 rs56193110 chr17:80151501 A/G cg19223190 chr17:80058835 NA 0.38 6.09 0.32 3.16e-9 Life satisfaction; CRC cis rs6840360 1.000 rs907237 chr4:152601146 T/G cg09659197 chr4:152720779 NA 0.5 10.63 0.51 6.99e-23 Intelligence (multi-trait analysis); CRC cis rs7923609 0.967 rs10740126 chr10:65210935 A/G cg08743896 chr10:65200160 JMJD1C -0.42 -6.12 -0.32 2.65e-9 Educational attainment;Liver enzyme levels (alkaline phosphatase); CRC cis rs1223397 1.000 rs1223399 chr6:13271220 G/A cg06879394 chr6:13274151 PHACTR1 0.53 6.48 0.34 3.3e-10 Blood pressure; CRC cis rs780096 0.526 rs704795 chr2:27716494 G/A cg02592271 chr2:27665507 KRTCAP3 -0.28 -6.41 -0.33 5.06e-10 Total body bone mineral density; CRC cis rs4253772 0.591 rs6007740 chr22:46654323 A/G cg09491104 chr22:46646882 C22orf40 0.52 8.1 0.41 1.09e-14 LDL cholesterol;Cholesterol, total; CRC trans rs2055729 0.645 rs6989793 chr8:9744650 A/G cg06636001 chr8:8085503 FLJ10661 -0.58 -7.13 -0.37 6.42e-12 Multiple myeloma (hyperdiploidy); CRC cis rs3733585 0.699 rs6449171 chr4:9965998 C/T cg11266682 chr4:10021025 SLC2A9 0.47 9.46 0.46 6.16e-19 Cleft plate (environmental tobacco smoke interaction); CRC cis rs7809950 1.000 rs2712191 chr7:107182724 C/G cg23024343 chr7:107201750 COG5 -0.62 -8.74 -0.43 1.18e-16 Coronary artery disease; CRC cis rs10493773 0.748 rs6576784 chr1:86149476 G/A cg17807903 chr1:86174739 ZNHIT6 -0.52 -11.7 -0.54 1.14e-26 Urate levels in overweight individuals; CRC cis rs3862260 0.509 rs10754416 chr1:120163531 A/G cg11530693 chr1:120165357 ZNF697 0.59 9.49 0.46 4.81e-19 Systemic lupus erythematosus; CRC cis rs728616 0.558 rs72817596 chr10:82151594 T/C cg11900509 chr10:81946545 ANXA11 -0.53 -6.06 -0.32 3.81e-9 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs2836974 0.627 rs7278985 chr21:40653767 C/T cg22974920 chr21:40686053 BRWD1 -0.43 -5.94 -0.31 7.38e-9 Cognitive function; CRC cis rs3820068 0.603 rs56032936 chr1:15970953 T/C cg27534772 chr1:16042836 PLEKHM2 0.54 10.12 0.49 3.78e-21 Systolic blood pressure; CRC cis rs3091242 0.933 rs34933589 chr1:25788198 T/C cg27572855 chr1:25598939 RHD -0.37 -6.44 -0.33 4.2e-10 Erythrocyte sedimentation rate; CRC cis rs9467711 0.606 rs2073530 chr6:26375243 T/C cg16898833 chr6:26189333 HIST1H4D 0.75 6.55 0.34 2.26e-10 Autism spectrum disorder or schizophrenia; CRC cis rs6502050 0.528 rs12942561 chr17:80116639 G/A cg13198984 chr17:80129470 CCDC57 0.45 8.07 0.41 1.3e-14 Life satisfaction; CRC cis rs2549003 1.000 rs2070726 chr5:131821738 C/A cg02551604 chr5:131831745 NA -0.54 -8.34 -0.42 2e-15 Asthma (sex interaction); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg26289871 chr20:39969385 LPIN3 -0.43 -7.67 -0.39 1.94e-13 Liver disease severity in Alagille syndrome; CRC cis rs9399135 1.000 rs1014021 chr6:135334600 C/T cg22676075 chr6:135203613 NA -0.39 -6.02 -0.31 4.73e-9 Red blood cell count; CRC cis rs10791323 0.604 rs2853116 chr11:133707063 A/G cg03690763 chr11:133734501 NA -0.35 -5.85 -0.31 1.22e-8 Childhood ear infection; CRC cis rs11212617 0.967 rs227076 chr11:108218905 T/C cg12106634 chr11:108092400 ATM;NPAT 0.43 6.33 0.33 8.07e-10 Response to metformin in type 2 diabetes (glycemic); CRC cis rs6570726 0.846 rs6914304 chr6:145921017 T/C cg23711669 chr6:146136114 FBXO30 0.67 11.09 0.52 1.7e-24 Lobe attachment (rater-scored or self-reported); CRC cis rs9929218 0.679 rs9924886 chr16:68743939 A/C cg02972257 chr16:68554789 NA 0.48 5.77 0.3 1.83e-8 Colorectal cancer; CRC cis rs6570726 0.599 rs4398765 chr6:145935006 C/A cg13319975 chr6:146136371 FBXO30 -0.63 -9.1 -0.45 9.04e-18 Lobe attachment (rater-scored or self-reported); CRC cis rs78545713 0.649 rs77727979 chr6:26222026 T/A cg01420254 chr6:26195488 NA 0.73 6.04 0.32 4.13e-9 Iron status biomarkers (total iron binding capacity); CRC cis rs1559088 0.600 rs10421769 chr19:33605312 T/C cg17764715 chr19:33622953 WDR88 0.44 6.41 0.33 5.15e-10 Bone ultrasound measurement (broadband ultrasound attenuation); CRC trans rs13315871 0.615 rs13066167 chr3:58340175 G/A cg25250853 chr2:85822726 RNF181 0.53 6.37 0.33 6.23e-10 Cholesterol, total; CRC cis rs1008375 1.000 rs9291659 chr4:17662360 A/C cg15017067 chr4:17643749 FAM184B 0.36 5.73 0.3 2.24e-8 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs4665809 0.590 rs6749046 chr2:26429451 C/G cg26119090 chr2:26468346 HADHA;HADHB 1.02 14.65 0.63 9.17e-38 Gut microbiome composition (summer); CRC cis rs9902453 0.904 rs9905638 chr17:28261022 C/G cg26525008 chr17:28256777 EFCAB5;SSH2 0.7 11.54 0.54 4.14e-26 Coffee consumption (cups per day); CRC cis rs2832191 1.000 rs2832184 chr21:30483265 C/T cg24692254 chr21:30365293 RNF160 -0.64 -11.05 -0.52 2.43e-24 Dental caries; CRC cis rs6496667 0.779 rs8035817 chr15:90974327 G/A cg04176472 chr15:90893244 GABARAPL3 0.59 8.16 0.41 7.28e-15 Rheumatoid arthritis; CRC cis rs9309473 1.000 rs10190219 chr2:73658331 C/T cg20560298 chr2:73613845 ALMS1 -0.47 -5.86 -0.31 1.1e-8 Metabolite levels; CRC cis rs4555082 0.834 rs2816624 chr14:105733909 A/G cg13114125 chr14:105738426 BRF1 -0.8 -11.63 -0.54 2.08e-26 Mean platelet volume;Platelet distribution width; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg18241048 chr10:5855009 GDI2 0.47 6.64 0.34 1.27e-10 Anxiety disorder; CRC cis rs7584330 0.554 rs113271883 chr2:238425594 A/G cg08992911 chr2:238395768 MLPH 0.47 5.83 0.31 1.3e-8 Prostate cancer; CRC trans rs1814175 0.529 rs1988417 chr11:49932430 A/G cg11707556 chr5:10655725 ANKRD33B -0.48 -8.03 -0.4 1.7e-14 Height; CRC cis rs2688608 0.592 rs11000760 chr10:75493734 G/A cg16540259 chr10:75572220 NDST2 0.38 5.91 0.31 8.64e-9 Inflammatory bowel disease; CRC cis rs10512697 0.772 rs62336081 chr5:3528961 G/A cg19473799 chr5:3511975 NA -0.83 -6.37 -0.33 6.34e-10 Immune response to smallpox vaccine (IL-6); CRC cis rs763014 0.932 rs2384975 chr16:651115 G/T cg04562611 chr16:615315 C16orf11 0.35 5.93 0.31 7.76e-9 Height; CRC cis rs514406 0.929 rs1672908 chr1:53340885 A/G cg08859206 chr1:53392774 SCP2 -0.44 -6.87 -0.35 3.13e-11 Monocyte count; CRC cis rs3857536 0.813 rs9360189 chr6:66933424 A/C cg07460842 chr6:66804631 NA -0.42 -5.7 -0.3 2.64e-8 Blood trace element (Cu levels); CRC cis rs9311676 0.632 rs7643057 chr3:58374015 C/T cg06643156 chr3:58380774 PXK 0.41 6.33 0.33 7.82e-10 Systemic lupus erythematosus; CRC cis rs17001868 0.568 rs17001846 chr22:40744053 A/G cg07138101 chr22:40742427 ADSL 0.6 7.9 0.4 4.13e-14 Mammographic density (dense area); CRC cis rs1949733 1.000 rs2631758 chr4:8495304 G/A cg13073564 chr4:8508604 NA 0.48 7.33 0.37 1.81e-12 Response to antineoplastic agents; CRC cis rs62064224 0.902 rs35830939 chr17:30627564 A/C cg21839984 chr17:30846986 MYO1D -0.36 -5.94 -0.31 7.4e-9 Schizophrenia; CRC cis rs875971 0.862 rs2909688 chr7:65841612 C/A cg18252515 chr7:66147081 NA -0.43 -6.05 -0.32 3.84e-9 Aortic root size; CRC cis rs59104589 0.583 rs62186377 chr2:242211450 A/G cg19488206 chr2:242435732 STK25 0.48 6.86 0.35 3.48e-11 Fibrinogen levels; CRC cis rs3892630 0.588 rs2112917 chr19:33317543 C/T cg22980127 chr19:33182716 NUDT19 0.93 12.47 0.57 1.75e-29 Red blood cell traits; CRC cis rs910316 1.000 rs175436 chr14:75608683 C/G cg03030879 chr14:75389066 RPS6KL1 0.47 7.31 0.37 2.03e-12 Height; CRC cis rs6951245 1.000 rs118059236 chr7:1073202 A/C cg03188948 chr7:1209495 NA 0.63 6.52 0.34 2.64e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs8099014 0.859 rs11152072 chr18:56098912 A/G cg19312305 chr18:56117016 MIR122 -0.38 -5.8 -0.3 1.54e-8 Platelet count; CRC cis rs7552404 0.731 rs931507 chr1:76401577 G/A cg22875332 chr1:76189707 ACADM -0.48 -6.17 -0.32 2.04e-9 Blood metabolite levels;Acylcarnitine levels; CRC trans rs11764590 0.715 rs9969125 chr7:2088460 C/T cg11693508 chr17:37793320 STARD3 0.6 6.88 0.35 3.01e-11 Neuroticism; CRC cis rs6547741 0.935 rs12615690 chr2:27851120 T/C cg27432699 chr2:27873401 GPN1 0.79 14.07 0.61 1.57e-35 Oral cavity cancer; CRC cis rs1044826 0.642 rs295470 chr3:139213903 A/G cg00490450 chr3:139108681 COPB2 0.43 6.4 0.33 5.37e-10 Obesity-related traits; CRC cis rs73206853 0.764 rs68087637 chr12:110619797 T/C cg12870014 chr12:110450643 ANKRD13A 0.83 10.86 0.51 1.07e-23 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC cis rs28386778 0.669 rs12603821 chr17:62006432 G/A cg25654072 chr17:61904446 PSMC5;FTSJ3 -0.48 -6.93 -0.36 2.26e-11 Prudent dietary pattern; CRC cis rs10883723 0.810 rs10883729 chr10:104273943 A/G cg11453585 chr10:104263688 ACTR1A;SUFU 0.9 16.71 0.68 8.48e-46 Allergic disease (asthma, hay fever or eczema); CRC cis rs6952808 0.531 rs1107351 chr7:2177093 G/A cg21782813 chr7:2030301 MAD1L1 0.49 8.39 0.42 1.5e-15 Bipolar disorder and schizophrenia; CRC cis rs807669 0.802 rs762528 chr22:19166680 A/G cg02655711 chr22:19163373 SLC25A1 0.99 20.9 0.76 2.54e-62 Metabolite levels; CRC cis rs6545883 0.772 rs1186709 chr2:61689380 G/A cg15711740 chr2:61764176 XPO1 -0.46 -5.98 -0.31 5.81e-9 Tuberculosis; CRC cis rs2050392 1.000 rs2265186 chr10:30691743 C/T cg18806716 chr10:30721971 MAP3K8 0.46 6.98 0.36 1.65e-11 Inflammatory bowel disease; CRC trans rs3960554 1.000 rs2097947 chr7:75836382 A/T cg19862616 chr7:65841803 NCRNA00174 0.66 8.08 0.41 1.25e-14 Eotaxin levels; CRC cis rs67340775 0.541 rs200966 chr6:27862152 T/C cg25164649 chr6:28176230 NA 0.58 5.91 0.31 8.68e-9 Lung cancer in ever smokers; CRC cis rs2404602 0.583 rs35707798 chr15:76565026 G/C cg22467129 chr15:76604101 ETFA -0.49 -8.65 -0.43 2.24e-16 Blood metabolite levels; CRC cis rs10504229 0.683 rs6999351 chr8:58127227 C/T cg04204079 chr8:58130323 NA -0.45 -5.78 -0.3 1.71e-8 Developmental language disorder (linguistic errors); CRC cis rs6546550 0.901 rs7598283 chr2:70128717 A/G cg02498382 chr2:70120550 SNRNP27 -0.56 -9.49 -0.46 4.98e-19 Prevalent atrial fibrillation; CRC cis rs2294693 0.947 rs10456496 chr6:40988840 A/G cg14769373 chr6:40998127 UNC5CL 0.5 6.77 0.35 5.8e-11 Gastric cancer;Non-cardia gastric cancer; CRC cis rs896854 0.548 rs574183 chr8:95973816 A/G cg16049864 chr8:95962084 TP53INP1 0.57 8.82 0.44 6.86e-17 Type 2 diabetes; CRC cis rs7590720 0.704 rs7603645 chr2:216876949 C/G cg25588852 chr2:216877276 MREG -0.35 -6.85 -0.35 3.63e-11 Alcohol dependence; CRC cis rs6545883 0.929 rs778155 chr2:61647901 A/G cg15711740 chr2:61764176 XPO1 0.46 6.11 0.32 2.81e-9 Tuberculosis; CRC cis rs2204008 0.837 rs11168387 chr12:37962818 G/A cg13010199 chr12:38710504 ALG10B -0.5 -7.3 -0.37 2.24e-12 Bladder cancer; CRC cis rs208520 0.690 rs207082 chr6:66773796 G/A cg07460842 chr6:66804631 NA -1.05 -14.41 -0.62 7.5e-37 Exhaled nitric oxide output; CRC cis rs7572733 0.592 rs113964240 chr2:198456310 C/A cg10820045 chr2:198174542 NA 0.35 6.28 0.33 1.04e-9 Dermatomyositis; CRC cis rs6089584 0.566 rs7274240 chr20:60622004 C/T cg06108461 chr20:60628389 TAF4 -0.76 -13.11 -0.59 6.81e-32 Body mass index; CRC cis rs7917772 0.636 rs2863718 chr10:104519631 G/C cg04362960 chr10:104952993 NT5C2 0.46 6.14 0.32 2.4e-9 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg03805410 chr22:42487359 NDUFA6 0.42 6.14 0.32 2.41e-9 Intelligence (multi-trait analysis); CRC cis rs3749237 1.000 rs11710675 chr3:49751900 C/A cg03060546 chr3:49711283 APEH 0.43 6.48 0.34 3.44e-10 Resting heart rate; CRC cis rs2816062 0.775 rs2816048 chr1:18893763 T/C cg18795169 chr1:18902165 NA -0.92 -19.28 -0.73 5.98e-56 Urate levels in lean individuals; CRC cis rs798554 0.634 rs6978692 chr7:2857411 C/T cg19717773 chr7:2847554 GNA12 -0.47 -8.01 -0.4 1.98e-14 Height; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg12404182 chr2:132250324 FAM128A;LOC150776 0.47 5.99 0.31 5.58e-9 Thyroid stimulating hormone; CRC cis rs1799949 0.536 rs4793227 chr17:41412250 A/C cg07153921 chr17:41440717 NA -0.4 -6.15 -0.32 2.3e-9 Menopause (age at onset); CRC cis rs9393692 0.620 rs9366650 chr6:26335997 G/A cg13736514 chr6:26305472 NA -0.47 -7.64 -0.39 2.39e-13 Educational attainment; CRC cis rs1223397 0.938 rs3817738 chr6:13279388 G/T cg20827128 chr6:13274284 PHACTR1 0.59 6.79 0.35 5.21e-11 Blood pressure; CRC cis rs10751667 0.666 rs7124480 chr11:971601 G/A cg06064525 chr11:970664 AP2A2 -0.34 -6.82 -0.35 4.25e-11 Alzheimer's disease (late onset); CRC cis rs7705042 0.865 rs4912622 chr5:141490587 A/G cg07392085 chr5:141489673 NDFIP1 -0.48 -7.57 -0.39 3.71e-13 Asthma; CRC cis rs6912958 0.781 rs9444519 chr6:88290398 T/C cg12350822 chr6:88032061 C6orf162;GJB7 -0.34 -6.37 -0.33 6.44e-10 Monocyte percentage of white cells; CRC cis rs12928939 0.517 rs10852507 chr16:71971900 G/A cg03805757 chr16:71968109 PKD1L3 -0.6 -7.92 -0.4 3.75e-14 Post bronchodilator FEV1; CRC cis rs6912958 0.781 rs3757368 chr6:88224495 T/C cg12350822 chr6:88032061 C6orf162;GJB7 -0.34 -6.41 -0.33 5.06e-10 Monocyte percentage of white cells; CRC cis rs10504229 1.000 rs67237174 chr8:58175776 T/C cg22535103 chr8:58192502 C8orf71 -0.81 -12.11 -0.56 3.71e-28 Developmental language disorder (linguistic errors); CRC cis rs62064224 0.905 rs9891969 chr17:30627085 C/T cg25809561 chr17:30822961 MYO1D 0.6 10.68 0.51 4.6e-23 Schizophrenia; CRC cis rs709400 0.663 rs1028613 chr14:103888324 G/A cg12935359 chr14:103987150 CKB -0.52 -8.02 -0.4 1.83e-14 Body mass index; CRC cis rs875971 1.000 rs4718343 chr7:65874288 T/G cg00343986 chr7:65444356 GUSB 0.43 6.3 0.33 9.66e-10 Aortic root size; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg02551244 chr2:23608357 KLHL29 0.47 6.04 0.32 4.19e-9 Thyroid stimulating hormone; CRC cis rs887797 0.518 rs8075979 chr17:64576138 C/T cg27019712 chr17:64599478 PRKCA -0.38 -5.79 -0.3 1.66e-8 Possible neuropathic pain in post total joint replacement surgery for osteoarthritis; CRC cis rs523522 0.962 rs12814055 chr12:120987391 G/A cg12219531 chr12:120966889 COQ5 0.69 9.3 0.46 2.03e-18 High light scatter reticulocyte count; CRC cis rs10256972 0.577 rs2949179 chr7:1209885 C/G cg23978390 chr7:1156363 C7orf50 0.41 5.65 0.3 3.47e-8 Longevity;Endometriosis; CRC cis rs2952156 0.883 rs8077172 chr17:37834977 G/T cg07936489 chr17:37558343 FBXL20 -0.4 -5.8 -0.3 1.53e-8 Asthma; CRC cis rs13108904 0.870 rs1960426 chr4:1274365 C/T cg00684032 chr4:1343700 KIAA1530 0.49 7.6 0.39 3.09e-13 Obesity-related traits; CRC cis rs950027 0.787 rs2433616 chr15:45728599 A/G cg21132104 chr15:45694354 SPATA5L1 0.44 6.45 0.34 4.01e-10 Response to fenofibrate (adiponectin levels); CRC cis rs6960043 0.818 rs10228066 chr7:15063569 C/T cg19272540 chr7:15055459 NA -0.22 -5.91 -0.31 8.61e-9 Type 2 diabetes; CRC cis rs2836950 0.762 rs8134638 chr21:40644170 T/C cg11644478 chr21:40555479 PSMG1 -0.42 -5.64 -0.3 3.71e-8 Menarche (age at onset); CRC cis rs780096 0.587 rs6760828 chr2:27579231 T/C cg17158414 chr2:27665306 KRTCAP3 -0.27 -5.65 -0.3 3.45e-8 Total body bone mineral density; CRC cis rs2243480 1.000 rs6959002 chr7:65650496 A/G cg25985355 chr7:65971099 NA 0.52 6.01 0.31 4.92e-9 Diabetic kidney disease; CRC cis rs523522 0.962 rs10849754 chr12:120940418 A/C cg27279351 chr12:120934652 DYNLL1 0.78 11.48 0.53 7.05e-26 High light scatter reticulocyte count; CRC cis rs9926296 0.585 rs8058009 chr16:89856439 G/C cg27130406 chr16:89901659 SPIRE2 -1.03 -12.41 -0.56 2.81e-29 Vitiligo; CRC cis rs2115630 0.967 rs8027779 chr15:85255385 T/C cg11189052 chr15:85197271 WDR73 -0.62 -9.86 -0.48 3.01e-20 P wave terminal force; CRC cis rs12413816 0.784 rs35537139 chr10:13768894 G/A cg16485048 chr10:13749193 FRMD4A 0.5 7.73 0.39 1.33e-13 Red cell distribution width; CRC cis rs76878669 0.561 rs10896111 chr11:66115690 T/C cg18002602 chr11:66138449 SLC29A2 -0.32 -6.69 -0.35 9.45e-11 Educational attainment (years of education); CRC cis rs7107174 0.901 rs7941639 chr11:78116959 A/G cg02023728 chr11:77925099 USP35 -0.4 -6.14 -0.32 2.34e-9 Testicular germ cell tumor; CRC cis rs7811142 0.830 rs73401450 chr7:99981859 G/C cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.13 16.15 0.66 1.32e-43 Platelet count; CRC trans rs2014572 0.967 rs7248000 chr19:57762139 C/T cg02674126 chr19:40336878 FBL 0.42 6.83 0.35 4.23e-11 Hyperactive-impulsive symptoms; CRC cis rs853679 0.882 rs9468300 chr6:28126840 C/T cg15845792 chr6:28175446 NA 0.8 6.52 0.34 2.67e-10 Depression; CRC cis rs34779708 0.931 rs4351760 chr10:35280254 A/G cg03585969 chr10:35415529 CREM 0.66 8.82 0.44 6.68e-17 Inflammatory bowel disease;Crohn's disease; CRC trans rs11581859 0.950 rs60534017 chr1:99370528 C/T cg12183875 chr3:169587454 LRRC31 0.26 6.13 0.32 2.55e-9 Response to cognitive-behavioural therapy in anxiety disorder; CRC cis rs6694672 1.000 rs6677082 chr1:197112533 G/A cg13682187 chr1:196946512 CFHR5 0.42 6.72 0.35 8.15e-11 Asthma; CRC cis rs4253772 0.591 rs6008361 chr22:46652372 A/G cg09491104 chr22:46646882 C22orf40 0.47 7.34 0.38 1.71e-12 LDL cholesterol;Cholesterol, total; CRC cis rs12887734 0.569 rs66953418 chr14:104271470 G/A cg08213375 chr14:104286397 PPP1R13B 0.5 8.5 0.42 6.74e-16 Schizophrenia;Autism spectrum disorder or schizophrenia; CRC trans rs1455244 0.700 rs7229302 chr18:11508904 G/T cg02069519 chr1:51985103 EPS15 0.4 6.27 0.33 1.16e-9 Schizophrenia; CRC trans rs561341 0.709 rs11542477 chr17:30185892 A/G cg27661571 chr11:113659931 NA 0.71 7.84 0.4 6.31e-14 Hip circumference adjusted for BMI; CRC cis rs7264396 0.635 rs6060688 chr20:34516731 C/G cg04508476 chr20:34239394 CPNE1;RBM12 0.58 10.19 0.49 2.25e-21 Total cholesterol levels; CRC cis rs904251 0.797 rs1757177 chr6:37486370 C/T cg25019722 chr6:37503610 NA -0.46 -8.49 -0.42 7e-16 Cognitive performance; CRC trans rs14057 0.827 rs6682920 chr1:6645867 C/T cg13000219 chr12:21590632 PYROXD1 0.4 6.14 0.32 2.38e-9 Systolic blood pressure; CRC cis rs10504229 0.817 rs114173899 chr8:58170640 G/T cg02725872 chr8:58115012 NA -0.38 -6.32 -0.33 8.27e-10 Developmental language disorder (linguistic errors); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg20306533 chr22:18507404 MICAL3 0.43 6.22 0.32 1.5e-9 Response to antipsychotic treatment; CRC cis rs7737355 0.812 rs3756289 chr5:130982194 A/G cg25547332 chr5:131281432 NA 0.36 5.65 0.3 3.56e-8 Life satisfaction; CRC cis rs4713118 0.866 rs9468217 chr6:27726467 G/A cg12172441 chr6:28176163 NA 0.55 6.53 0.34 2.43e-10 Parkinson's disease; CRC cis rs11748023 0.605 rs156090 chr5:139521684 T/C cg26211634 chr5:139558579 C5orf32 0.35 6.03 0.32 4.45e-9 Intelligence (multi-trait analysis); CRC cis rs6502050 0.805 rs9898507 chr17:80119628 C/T cg13198984 chr17:80129470 CCDC57 0.47 8.35 0.42 1.88e-15 Life satisfaction; CRC cis rs4713118 0.662 rs175954 chr6:28011585 A/G cg12172441 chr6:28176163 NA 0.57 7.51 0.38 5.5e-13 Parkinson's disease; CRC cis rs6089584 0.566 rs11699442 chr20:60623268 A/G cg23463467 chr20:60627584 TAF4 0.43 8.13 0.41 8.67e-15 Body mass index; CRC cis rs1670533 1.000 rs10026482 chr4:1051128 C/G cg27284194 chr4:1044797 NA 0.51 6.3 0.33 9.48e-10 Recombination rate (females); CRC cis rs9303401 0.659 rs12150264 chr17:56939927 G/A cg02118635 chr17:56770003 RAD51C;TEX14 0.77 9.84 0.48 3.28e-20 Cognitive test performance; CRC cis rs67311347 1.000 rs73078123 chr3:40458963 G/A cg09455208 chr3:40491958 NA 0.49 9.36 0.46 1.28e-18 Renal cell carcinoma; CRC cis rs947211 0.950 rs885224 chr1:205753097 A/G cg07157834 chr1:205819609 PM20D1 0.44 6.1 0.32 2.99e-9 Parkinson's disease; CRC cis rs7726839 0.561 rs72703044 chr5:579737 G/A cg09021430 chr5:549028 NA -0.86 -10.87 -0.51 9.9e-24 Obesity-related traits; CRC cis rs7584330 0.554 rs10173100 chr2:238433040 A/G cg14458575 chr2:238380390 NA 0.53 7.01 0.36 1.36e-11 Prostate cancer; CRC cis rs61996546 0.622 rs2873027 chr15:26867409 C/T cg15066197 chr15:26874202 GABRB3 -0.39 -5.99 -0.31 5.37e-9 Response to methotrexate in juvenile idiopathic arthritis; CRC cis rs12586317 0.514 rs74590021 chr14:35490113 T/G cg05294307 chr14:35346193 BAZ1A -0.69 -7.52 -0.38 5.37e-13 Psoriasis; CRC cis rs3617 0.598 rs56214994 chr3:52878600 G/C cg05573699 chr3:52720067 GNL3;PBRM1 0.37 5.6 0.3 4.48e-8 Red blood cell count;Autism spectrum disorder or schizophrenia; CRC trans rs1997103 1.000 rs1997103 chr7:55395390 C/G cg20935933 chr6:143382018 AIG1 0.53 6.8 0.35 5e-11 QRS interval (sulfonylurea treatment interaction); CRC cis rs34779708 0.966 rs12773647 chr10:35440327 A/G cg03585969 chr10:35415529 CREM 0.61 8.17 0.41 6.59e-15 Inflammatory bowel disease;Crohn's disease; CRC trans rs747782 0.585 rs1604655 chr11:48274778 G/A cg03929089 chr4:120376271 NA 0.67 6.62 0.34 1.45e-10 Intraocular pressure; CRC cis rs10504229 0.953 rs75253516 chr8:58171547 C/A cg02725872 chr8:58115012 NA -0.38 -6.31 -0.33 9.08e-10 Developmental language disorder (linguistic errors); CRC cis rs2276314 0.857 rs28379448 chr18:33604364 C/A cg19628046 chr18:33552617 C18orf21 0.53 6.91 0.36 2.48e-11 Endometriosis;Drug-induced torsades de pointes; CRC cis rs11608355 0.545 rs12823587 chr12:109896390 A/G cg05360138 chr12:110035743 NA 0.77 8.7 0.43 1.65e-16 Neuroticism; CRC cis rs2742540 0.524 rs2653562 chr11:8918160 A/T cg00186954 chr11:8933980 ST5;C11orf17 -0.65 -11.69 -0.54 1.25e-26 Hematocrit; CRC cis rs4821897 0.514 rs739141 chr22:39824450 A/G cg25459000 chr22:39777742 SYNGR1 0.32 5.87 0.31 1.05e-8 IgG glycosylation; CRC cis rs1153858 1.000 rs1890565 chr15:45663299 T/C cg14582100 chr15:45693742 SPATA5L1 0.29 5.97 0.31 6.07e-9 Homoarginine levels; CRC cis rs10982256 0.774 rs998548 chr9:117275182 C/T cg13636371 chr9:117264095 DFNB31 0.35 6.82 0.35 4.37e-11 Bipolar disorder; CRC cis rs1023500 0.551 rs133379 chr22:42468535 A/G cg04733989 chr22:42467013 NAGA 0.61 9.0 0.44 1.84e-17 Schizophrenia; CRC cis rs910316 0.763 rs13712 chr14:75483812 T/C cg11812906 chr14:75593930 NEK9 0.59 9.17 0.45 5.19e-18 Height; CRC cis rs6502050 0.835 rs3935816 chr17:80137173 C/T cg25804541 chr17:80189381 SLC16A3 -0.3 -5.67 -0.3 3.16e-8 Life satisfaction; CRC cis rs7647973 0.922 rs7620024 chr3:49451691 G/A cg07636037 chr3:49044803 WDR6 -0.66 -7.96 -0.4 2.76e-14 Menarche (age at onset); CRC cis rs8060686 1.000 rs8060686 chr16:67911517 T/C cg26727032 chr16:67993705 SLC12A4 -0.74 -12.24 -0.56 1.22e-28 HDL cholesterol;Metabolic syndrome; CRC cis rs807029 0.533 rs2863095 chr10:102746503 C/T cg04662943 chr10:102668895 NA 0.65 7.45 0.38 8.54e-13 Ejection fraction in Tripanosoma cruzi seropositivity; CRC cis rs713477 0.967 rs6573032 chr14:55913776 A/G cg21836586 chr14:55907198 TBPL2 0.3 5.6 0.3 4.51e-8 Pediatric bone mineral content (femoral neck); CRC cis rs6089584 0.854 rs6061407 chr20:60622048 A/C cg13770153 chr20:60521292 NA -0.57 -8.65 -0.43 2.25e-16 Body mass index; CRC cis rs668210 0.793 rs586921 chr11:65747701 G/A cg02202077 chr11:65769826 EIF1AD;BANF1 -0.53 -6.59 -0.34 1.73e-10 Cerebrospinal fluid biomarker levels; CRC cis rs9902453 0.765 rs6505143 chr17:28150585 A/C cg26525008 chr17:28256777 EFCAB5;SSH2 0.73 12.3 0.56 7.06e-29 Coffee consumption (cups per day); CRC cis rs9948 0.655 rs62156232 chr2:97431161 C/A cg20312557 chr2:97357134 FER1L5 -0.61 -5.63 -0.3 3.87e-8 Erectile dysfunction and prostate cancer treatment; CRC cis rs3749237 0.595 rs4855864 chr3:49521974 C/T cg07636037 chr3:49044803 WDR6 0.55 8.05 0.41 1.54e-14 Resting heart rate; CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg04652621 chr7:150671807 KCNH2 0.38 6.01 0.31 4.83e-9 Obesity-related traits; CRC trans rs7615952 0.512 rs34651730 chr3:125358640 T/C cg07211511 chr3:129823064 LOC729375 -0.63 -8.76 -0.43 1.03e-16 Blood pressure (smoking interaction); CRC cis rs896854 0.967 rs2879813 chr8:95960947 A/G cg09323728 chr8:95962352 TP53INP1 -0.43 -7.16 -0.37 5.19e-12 Type 2 diabetes; CRC cis rs6459788 0.527 rs6980250 chr7:157228710 C/T cg17306686 chr7:157230923 NA 0.46 6.64 0.34 1.29e-10 Epstein-Barr virus copy number in lymphoblastoid cell lines; CRC cis rs758324 0.947 rs56081930 chr5:131235274 T/G cg06307176 chr5:131281290 NA -0.41 -6.1 -0.32 3.02e-9 Alzheimer's disease in APOE e4- carriers; CRC cis rs2976388 0.632 rs2585139 chr8:143808175 C/G cg22687807 chr8:143858763 LYNX1 0.51 8.99 0.44 2.05e-17 Urinary tract infection frequency; CRC cis rs2880765 0.743 rs8039631 chr15:86007931 A/G cg17133734 chr15:86042851 AKAP13 0.4 6.34 0.33 7.51e-10 Coronary artery disease; CRC cis rs853679 0.760 rs967005 chr6:28210688 C/T cg12273811 chr6:28175739 NA 0.55 5.86 0.31 1.12e-8 Depression; CRC cis rs10504229 1.000 rs114312649 chr8:58182539 C/G cg01721255 chr8:58191610 C8orf71 0.49 6.17 0.32 2e-9 Developmental language disorder (linguistic errors); CRC cis rs7149337 0.837 rs4296182 chr14:51662167 A/C cg23942311 chr14:51606299 NA 0.78 14.78 0.63 3.03e-38 Cancer; CRC cis rs6089584 0.888 rs6089623 chr20:60615759 A/G cg06108461 chr20:60628389 TAF4 -0.94 -16.18 -0.67 9.6e-44 Body mass index; CRC trans rs2727020 0.595 rs11040416 chr11:49566429 C/T cg11707556 chr5:10655725 ANKRD33B -0.4 -7.55 -0.38 4.37e-13 Coronary artery disease; CRC cis rs300703 0.654 rs401364 chr2:119493 G/A cg21211680 chr2:198530 NA -1.0 -11.37 -0.53 1.79e-25 Blood protein levels; CRC cis rs6546324 0.625 rs1430791 chr2:67864800 A/C cg15745817 chr2:67799979 NA -0.55 -9.57 -0.47 2.68e-19 Endometriosis; CRC cis rs422249 0.512 rs174583 chr11:61609750 A/G cg00603274 chr11:61596626 FADS2 0.45 6.64 0.34 1.29e-10 Trans fatty acid levels; CRC cis rs34779708 0.733 rs4244997 chr10:35547254 T/C cg03585969 chr10:35415529 CREM 0.52 6.79 0.35 5.37e-11 Inflammatory bowel disease;Crohn's disease; CRC cis rs2290405 0.527 rs4690332 chr4:910520 C/T cg04824913 chr4:887549 GAK -0.68 -10.49 -0.5 2.2e-22 Systemic sclerosis; CRC cis rs1799949 1.000 rs11657053 chr17:41191129 G/T cg01879757 chr17:41196368 BRCA1 -0.41 -6.06 -0.32 3.7e-9 Menopause (age at onset); CRC cis rs4253772 0.591 rs6007726 chr22:46650858 A/C cg09491104 chr22:46646882 C22orf40 -0.48 -7.51 -0.38 5.72e-13 LDL cholesterol;Cholesterol, total; CRC cis rs1008375 0.931 rs6449310 chr4:17575530 T/C cg02297831 chr4:17616191 MED28 0.46 5.94 0.31 7.31e-9 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs11690935 0.632 rs12998411 chr2:172530707 G/C cg13550731 chr2:172543902 DYNC1I2 0.68 10.19 0.49 2.28e-21 Schizophrenia; CRC cis rs9649213 0.593 rs7812180 chr7:97969140 A/G cg21770322 chr7:97807741 LMTK2 -0.55 -8.78 -0.44 8.91e-17 Prostate cancer (SNP x SNP interaction); CRC cis rs12477438 0.765 rs62154638 chr2:99639584 C/T cg26064155 chr2:99771622 LIPT1;TSGA10 -0.63 -8.55 -0.43 4.57e-16 Chronic sinus infection; CRC cis rs9549367 0.713 rs2476319 chr13:113836519 C/T cg24300038 chr13:113819356 PROZ 0.51 6.69 0.35 9.53e-11 Platelet distribution width; CRC cis rs9443645 0.901 rs9361460 chr6:79589467 C/G cg09184832 chr6:79620586 NA -0.5 -9.44 -0.46 7.24e-19 Intelligence (multi-trait analysis); CRC cis rs3751196 0.901 rs117053620 chr12:104191196 G/A cg02344784 chr12:104178138 NT5DC3 0.68 6.96 0.36 1.91e-11 Sense of smell; CRC cis rs2070488 0.965 rs2284820 chr3:38562579 C/T cg01465620 chr3:38496096 LOC100128640;ACVR2B -0.89 -16.47 -0.67 7.23e-45 Electrocardiographic conduction measures; CRC cis rs311392 1.000 rs413974 chr8:55088510 A/G cg06042504 chr8:55087323 NA -0.42 -6.44 -0.33 4.21e-10 Pelvic organ prolapse (moderate/severe); CRC cis rs713477 1.000 rs28478984 chr14:55911326 C/A cg13175173 chr14:55914753 NA -0.52 -9.85 -0.48 3.19e-20 Pediatric bone mineral content (femoral neck); CRC trans rs916888 0.647 rs199449 chr17:44808902 G/A cg22433210 chr17:43662623 NA 0.62 7.62 0.39 2.76e-13 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs2019137 0.936 rs3828189 chr2:113954496 T/A cg21610815 chr2:113994035 PAX8;LOC654433;LOC440839 -0.45 -6.28 -0.33 1.09e-9 Lymphocyte counts; CRC cis rs2200578 1.000 rs60025964 chr2:99880577 G/T cg26064155 chr2:99771622 LIPT1;TSGA10 0.59 6.42 0.33 4.85e-10 IgG glycosylation; CRC cis rs4930103 0.935 rs11042167 chr11:2020901 G/A cg23202291 chr11:1979235 NA 0.48 6.59 0.34 1.78e-10 DNA methylation (parent-of-origin);DNA methylation (variation); CRC cis rs1448094 0.967 rs7978132 chr12:86323484 T/C cg19622623 chr12:86230825 RASSF9 -0.35 -5.69 -0.3 2.8e-8 Major depressive disorder; CRC cis rs7786808 0.741 rs11765319 chr7:158226790 A/G cg01191920 chr7:158217561 PTPRN2 -0.82 -15.23 -0.64 5.3e-40 Obesity-related traits; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg01353139 chr8:124170018 NA 0.38 6.12 0.32 2.6e-9 Liver disease severity in Alagille syndrome; CRC cis rs10504229 0.683 rs67035623 chr8:58139963 G/T cg05313129 chr8:58192883 C8orf71 -0.43 -6.11 -0.32 2.74e-9 Developmental language disorder (linguistic errors); CRC cis rs7178572 0.568 rs1565757 chr15:77657682 C/T cg22256960 chr15:77711686 NA -0.71 -10.36 -0.5 5.74e-22 Type 2 diabetes; CRC cis rs2243480 1.000 rs431076 chr7:65600320 A/C cg18252515 chr7:66147081 NA -1.25 -14.84 -0.63 1.63e-38 Diabetic kidney disease; CRC cis rs1005224 0.926 rs12892551 chr14:76159902 C/T cg25116370 chr14:76127843 TTLL5;C14orf1 -0.39 -5.88 -0.31 9.87e-9 Large artery stroke; CRC cis rs10782582 0.569 rs4549990 chr1:76125075 A/G cg10523679 chr1:76189770 ACADM -0.4 -5.66 -0.3 3.28e-8 Daytime sleep phenotypes; CRC cis rs11622475 1.000 rs10149651 chr14:104394440 A/G cg12183467 chr14:104352244 NA 0.49 6.73 0.35 7.65e-11 Bipolar disorder; CRC cis rs2797160 0.651 rs1268066 chr6:126035041 C/T cg05901451 chr6:126070800 HEY2 0.48 7.72 0.39 1.38e-13 Endometrial cancer; CRC cis rs2980436 1 rs2980436 chr8:8092025 A/G cg08975724 chr8:8085496 FLJ10661 -0.47 -6.79 -0.35 5.15e-11 Schizophrenia; CRC cis rs6582630 0.502 rs10880450 chr12:38440294 G/C cg26384229 chr12:38710491 ALG10B 0.66 9.07 0.45 1.13e-17 Drug-induced liver injury (flucloxacillin); CRC cis rs6973256 0.762 rs11768260 chr7:133430482 T/C cg10665199 chr7:133106180 EXOC4 -0.39 -5.8 -0.3 1.58e-8 Intelligence (multi-trait analysis); CRC cis rs1707322 1.000 rs7531911 chr1:46330423 A/G cg06784218 chr1:46089804 CCDC17 0.51 8.92 0.44 3.3e-17 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs9467711 0.538 rs35942482 chr6:26444938 T/A cg08501292 chr6:25962987 TRIM38 0.83 6.43 0.33 4.44e-10 Autism spectrum disorder or schizophrenia; CRC cis rs6952808 0.792 rs12536261 chr7:1953571 G/A cg00106254 chr7:1943704 MAD1L1 -0.5 -7.37 -0.38 1.39e-12 Bipolar disorder and schizophrenia; CRC cis rs11148252 0.574 rs7139495 chr13:53283318 A/G cg20354231 chr13:53171401 NA -0.43 -6.87 -0.35 3.22e-11 Lewy body disease; CRC cis rs6754311 0.731 rs687670 chr2:136740900 T/C cg15123519 chr2:136567270 LCT -0.32 -6.11 -0.32 2.8e-9 Mosquito bite size; CRC cis rs6952808 0.542 rs10243920 chr7:1950385 G/A cg04267008 chr7:1944627 MAD1L1 -0.66 -10.4 -0.5 4.45e-22 Bipolar disorder and schizophrenia; CRC cis rs17666538 0.585 rs4735812 chr8:607766 C/G cg13264159 chr8:625131 ERICH1 -0.77 -7.18 -0.37 4.69e-12 IgG glycosylation; CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg15312298 chr8:127570908 FAM84B -0.51 -6.45 -0.34 4.01e-10 Diisocyanate-induced asthma; CRC cis rs7605827 0.964 rs6733847 chr2:15564930 G/A cg19274914 chr2:15703543 NA 0.39 5.96 0.31 6.62e-9 Educational attainment (years of education); CRC cis rs7666738 0.830 rs6827516 chr4:98971740 T/C cg17366294 chr4:99064904 C4orf37 0.44 7.44 0.38 8.98e-13 Colonoscopy-negative controls vs population controls; CRC cis rs951366 0.617 rs708727 chr1:205767885 G/A cg11965913 chr1:205819406 PM20D1 1.03 19.74 0.74 8.73e-58 Menarche (age at onset); CRC cis rs1005277 0.563 rs2800550 chr10:38482929 T/C cg25517755 chr10:38738941 LOC399744 -0.44 -6.44 -0.33 4.31e-10 Extrinsic epigenetic age acceleration; CRC cis rs4819052 0.851 rs35560973 chr21:46662573 T/C cg19498844 chr21:46707878 POFUT2;LOC642852 0.7 10.22 0.49 1.8e-21 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs7659604 1.000 rs7660078 chr4:122665577 G/T cg19748678 chr4:122722346 EXOSC9 0.56 8.9 0.44 3.69e-17 Type 2 diabetes; CRC cis rs7660520 0.524 rs4862100 chr4:183732709 G/T cg01126855 chr4:183727586 NA 0.63 6.07 0.32 3.57e-9 Pediatric autoimmune diseases; CRC cis rs9309473 1.000 rs9309473 chr2:73743982 A/G cg20560298 chr2:73613845 ALMS1 -0.5 -6.04 -0.32 4.15e-9 Metabolite levels; CRC cis rs4664293 1.000 rs10204535 chr2:160463692 C/T cg08347373 chr2:160653686 CD302 -0.38 -6.31 -0.33 9.11e-10 Monocyte percentage of white cells; CRC trans rs16846053 0.792 rs56374905 chr2:162631445 G/C cg18226098 chr19:917109 KISS1R -0.64 -6.03 -0.32 4.46e-9 Blood osmolality (transformed sodium); CRC cis rs7605827 0.930 rs11676730 chr2:15563573 C/T cg19274914 chr2:15703543 NA 0.38 5.76 0.3 1.9e-8 Educational attainment (years of education); CRC cis rs2239547 0.562 rs6794389 chr3:53096394 A/G cg11645453 chr3:52864694 ITIH4 0.51 8.55 0.43 4.7e-16 Schizophrenia; CRC cis rs1862618 0.573 rs2034245 chr5:56243685 T/C cg24531977 chr5:56204891 C5orf35 0.96 14.14 0.61 8.42e-36 Initial pursuit acceleration; CRC cis rs7666738 0.830 rs6848397 chr4:98946738 A/G cg05340658 chr4:99064831 C4orf37 0.61 9.54 0.47 3.45e-19 Colonoscopy-negative controls vs population controls; CRC cis rs7937682 0.602 rs503905 chr11:111390762 G/C cg19812747 chr11:111475976 SIK2 -0.5 -7.92 -0.4 3.82e-14 Primary sclerosing cholangitis; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg21871735 chr16:2015157 SNHG9;RPS2;SNORA78 0.47 6.62 0.34 1.46e-10 Response to antipsychotic treatment; CRC cis rs67311347 1.000 rs2887995 chr3:40409029 C/G cg24209194 chr3:40518798 ZNF619 0.42 6.51 0.34 2.8e-10 Renal cell carcinoma; CRC cis rs1218582 0.772 rs12069356 chr1:154849771 C/T cg16680214 chr1:154839983 KCNN3 -0.49 -9.89 -0.48 2.38e-20 Prostate cancer; CRC cis rs1005277 0.579 rs2472178 chr10:38384750 T/C cg03665457 chr10:38645376 HSD17B7P2 -0.42 -6.03 -0.32 4.49e-9 Extrinsic epigenetic age acceleration; CRC cis rs6504622 0.905 rs736604 chr17:45024809 C/T cg16759221 chr17:45003025 GOSR2 -0.54 -8.45 -0.42 9.25e-16 Orofacial clefts; CRC cis rs6665290 0.901 rs7535826 chr1:227213968 A/C cg10327440 chr1:227177885 CDC42BPA 0.92 18.17 0.71 1.46e-51 Myeloid white cell count; CRC cis rs6502050 0.764 rs28676462 chr17:80105100 G/C cg11859384 chr17:80120422 CCDC57 -0.37 -5.85 -0.31 1.16e-8 Life satisfaction; CRC cis rs11758351 0.734 rs56220351 chr6:26206884 A/G cg01420254 chr6:26195488 NA 0.78 8.67 0.43 1.97e-16 Gout;Renal underexcretion gout; CRC cis rs67311347 0.876 rs13068097 chr3:40504424 T/A cg24209194 chr3:40518798 ZNF619 -0.42 -6.37 -0.33 6.31e-10 Renal cell carcinoma; CRC cis rs7762018 1.000 rs4716380 chr6:170090399 A/G cg17545662 chr6:170176663 C6orf70 0.55 6.02 0.31 4.78e-9 Thiazide-induced adverse metabolic effects in hypertensive patients; CRC cis rs6762 0.748 rs3059 chr11:840319 C/T cg03885332 chr11:832357 CD151 -0.42 -6.21 -0.32 1.61e-9 Mean platelet volume; CRC cis rs951366 0.589 rs823099 chr1:205669322 C/A cg26354017 chr1:205819088 PM20D1 0.7 9.86 0.48 2.94e-20 Menarche (age at onset); CRC cis rs2976388 0.566 rs2585141 chr8:143806343 G/A cg22687807 chr8:143858763 LYNX1 -0.48 -7.87 -0.4 5.12e-14 Urinary tract infection frequency; CRC cis rs7811142 1.000 rs76913697 chr7:100002772 A/G cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.62 8.08 0.41 1.22e-14 Platelet count; CRC cis rs9912789 0.807 rs9896850 chr17:79191726 C/T cg14413466 chr17:79170920 AZI1 -0.39 -6.68 -0.35 9.9e-11 Frontotemporal dementia; CRC cis rs2576037 0.501 rs8089938 chr18:44459497 C/T cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.72 -11.64 -0.54 1.91e-26 Personality dimensions; CRC cis rs2153535 0.580 rs1932283 chr6:8477661 C/T cg07606381 chr6:8435919 SLC35B3 0.67 10.78 0.51 2.08e-23 Motion sickness; CRC trans rs10982213 0.830 rs2274163 chr9:117188714 C/T cg13575638 chr3:9440081 SETD5;LOC440944 0.39 6.08 0.32 3.36e-9 Interleukin-6 levels; CRC cis rs9549328 0.614 rs35299896 chr13:113617229 G/T cg24588162 chr13:113633484 MCF2L 0.36 6.51 0.34 2.89e-10 Systolic blood pressure; CRC cis rs6502050 0.769 rs9898542 chr17:80119682 C/T cg25804541 chr17:80189381 SLC16A3 -0.31 -5.95 -0.31 6.84e-9 Life satisfaction; CRC cis rs727505 0.954 rs2170352 chr7:124605584 G/A cg23710748 chr7:124431027 NA -0.81 -14.19 -0.62 5.26e-36 Lewy body disease; CRC cis rs72945132 0.825 rs72947052 chr11:70188575 A/G cg14191688 chr11:70257035 CTTN 0.57 6.99 0.36 1.55e-11 Coronary artery disease; CRC cis rs8072100 0.738 rs9895509 chr17:45549618 A/T cg08085267 chr17:45401833 C17orf57 0.57 8.81 0.44 7.39e-17 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs7589728 1.000 rs6722069 chr2:88533151 C/T cg07952391 chr2:88470173 THNSL2 0.63 6.38 0.33 5.99e-10 Plasma clusterin levels; CRC cis rs4713118 0.662 rs9468276 chr6:28027688 A/C cg15845792 chr6:28175446 NA 0.95 13.73 0.6 3.05e-34 Parkinson's disease; CRC cis rs7666738 0.830 rs28785514 chr4:98959135 G/A cg05340658 chr4:99064831 C4orf37 0.61 9.54 0.47 3.45e-19 Colonoscopy-negative controls vs population controls; CRC cis rs7412746 0.611 rs111905669 chr1:150777565 T/C cg17724175 chr1:150552817 MCL1 0.47 6.97 0.36 1.7e-11 Melanoma; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg18635645 chr1:85667791 SYDE2 0.44 6.53 0.34 2.47e-10 Response to antipsychotic treatment; CRC trans rs7615952 0.512 rs2979334 chr3:125358824 G/A cg17147758 chr8:6949321 NA -0.52 -7.2 -0.37 4.24e-12 Blood pressure (smoking interaction); CRC cis rs8180040 0.966 rs12636851 chr3:47463567 C/T cg02527881 chr3:46936655 PTH1R -0.37 -6.81 -0.35 4.77e-11 Colorectal cancer; CRC cis rs4692589 1.000 rs4692783 chr4:170935407 G/A cg19918862 chr4:170955249 NA 0.38 6.29 0.33 1.03e-9 Anxiety disorder; CRC cis rs10857712 0.754 rs1052582 chr10:135233840 C/G cg17796960 chr10:135278976 LOC619207 -0.37 -5.65 -0.3 3.53e-8 Systemic lupus erythematosus; CRC cis rs4713118 0.513 rs149950 chr6:28033039 T/G cg23161317 chr6:28129485 ZNF389 0.45 6.5 0.34 3.01e-10 Parkinson's disease; CRC cis rs972578 1.000 rs2267481 chr22:43363889 A/G cg01576275 chr22:43409880 NA -0.45 -7.27 -0.37 2.62e-12 Mean platelet volume; CRC trans rs4714291 0.802 rs2983143 chr6:40044850 G/T cg02267698 chr19:7991119 CTXN1 -0.45 -6.09 -0.32 3.09e-9 Strep throat; CRC cis rs72945132 0.882 rs67244582 chr11:70122009 G/A cg00319359 chr11:70116639 PPFIA1 0.68 7.5 0.38 6.05e-13 Coronary artery disease; CRC cis rs2710642 0.962 rs7557501 chr2:63086639 C/T cg17519650 chr2:63277830 OTX1 0.45 6.4 0.33 5.31e-10 LDL cholesterol levels;LDL cholesterol; CRC cis rs10504229 0.683 rs7460059 chr8:58111561 C/T cg21724239 chr8:58056113 NA 0.5 6.89 0.35 2.89e-11 Developmental language disorder (linguistic errors); CRC trans rs10983614 1.000 rs7867776 chr9:120072627 A/G cg25229015 chr15:78591883 WDR61 0.46 6.01 0.31 4.97e-9 Survival in pancreatic cancer; CRC cis rs1451375 0.617 rs10267323 chr7:50591424 A/G cg18232548 chr7:50535776 DDC 0.45 5.86 0.31 1.12e-8 Malaria; CRC trans rs1814175 0.645 rs28447324 chr11:50046629 C/A cg11707556 chr5:10655725 ANKRD33B -0.52 -10.16 -0.49 2.82e-21 Height; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg04696171 chr16:89787876 C16orf7;ZNF276 0.39 6.3 0.33 9.73e-10 Liver disease severity in Alagille syndrome; CRC cis rs9318086 0.648 rs78881146 chr13:24468704 G/A cg25267304 chr13:24462978 PCOTH;MIPEP 0.68 10.86 0.51 1.14e-23 Myopia (pathological); CRC cis rs853679 0.517 rs9368552 chr6:28068426 A/G cg03623178 chr6:28175578 NA 0.95 12.46 0.57 1.93e-29 Depression; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg15560884 chr1:710097 NA -0.46 -8.76 -0.43 1.08e-16 Liver disease severity in Alagille syndrome; CRC cis rs9467711 0.538 rs7750960 chr6:25887217 A/C cg16898833 chr6:26189333 HIST1H4D 0.65 5.76 0.3 1.88e-8 Autism spectrum disorder or schizophrenia; CRC cis rs6598955 0.671 rs12145403 chr1:26597189 C/T cg04990556 chr1:26633338 UBXN11 0.54 5.81 0.3 1.51e-8 Obesity-related traits; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg01524359 chr1:46049306 NASP 0.48 6.65 0.34 1.21e-10 Response to antipsychotic treatment; CRC cis rs1045714 0.848 rs73033686 chr7:2635085 C/G cg24848437 chr7:2645542 IQCE 0.59 6.06 0.32 3.66e-9 Urate levels in lean individuals; CRC cis rs2737618 0.674 rs2821334 chr1:200093887 G/T cg21825944 chr1:200113062 NR5A2 -0.52 -7.51 -0.38 5.67e-13 Uric acid levels; CRC cis rs974417 0.508 rs17743380 chr6:97312271 C/T cg14723344 chr6:97285662 GPR63 0.41 5.91 0.31 8.7e-9 Body mass index; CRC cis rs6598955 0.671 rs17163751 chr1:26568698 A/G cg04990556 chr1:26633338 UBXN11 0.56 6.02 0.32 4.53e-9 Obesity-related traits; CRC trans rs7395662 1.000 rs7925955 chr11:48647533 C/T cg21153622 chr11:89784906 NA -0.48 -7.76 -0.39 1.07e-13 HDL cholesterol; CRC cis rs17270561 0.609 rs9358878 chr6:25740273 C/T cg17691542 chr6:26056736 HIST1H1C 0.73 9.31 0.46 1.85e-18 Iron status biomarkers; CRC cis rs12692738 0.526 rs355872 chr2:165632206 T/C cg03182029 chr2:165697222 COBLL1 0.5 5.86 0.31 1.11e-8 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);Waist-to-hip ratio adjusted for BMI in non-smokers;Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction);Waist-to-hip ratio adjusted for body mass index; CRC cis rs7666738 0.830 rs11725652 chr4:98878362 G/A cg05340658 chr4:99064831 C4orf37 0.56 8.4 0.42 1.31e-15 Colonoscopy-negative controls vs population controls; CRC cis rs9534288 0.730 rs2148412 chr13:46595849 C/T cg15192986 chr13:46630673 CPB2 -0.65 -9.77 -0.47 5.75e-20 Blood protein levels; CRC cis rs477692 1.000 rs548390 chr10:131417427 G/A cg05714579 chr10:131428358 MGMT 0.55 8.16 0.41 7.39e-15 Response to temozolomide; CRC cis rs2153535 0.580 rs2327060 chr6:8447111 G/A cg21535247 chr6:8435926 SLC35B3 0.49 7.4 0.38 1.15e-12 Motion sickness; CRC cis rs853679 0.517 rs4711164 chr6:28115156 C/T cg02631126 chr6:28058918 ZSCAN12L1 0.29 5.91 0.31 8.38e-9 Depression; CRC cis rs10504229 0.728 rs72650856 chr8:58152695 C/T cg02290350 chr8:58132656 NA -0.51 -6.57 -0.34 1.98e-10 Developmental language disorder (linguistic errors); CRC cis rs8180040 0.620 rs6414435 chr3:47121140 A/G cg27129171 chr3:47204927 SETD2 0.72 11.31 0.53 2.77e-25 Colorectal cancer; CRC cis rs12024301 0.557 rs6661715 chr1:183622314 A/G cg11505048 chr1:183622726 RGL1;APOBEC4 0.75 6.66 0.34 1.14e-10 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs950169 0.881 rs4842852 chr15:84941961 A/G cg11189052 chr15:85197271 WDR73 0.63 8.8 0.44 7.65e-17 Schizophrenia; CRC cis rs172166 0.516 rs1150670 chr6:28130559 A/G cg15786705 chr6:28176104 NA 0.48 7.18 0.37 4.74e-12 Cardiac Troponin-T levels; CRC cis rs7524258 0.868 rs916393 chr1:7272250 T/C cg07173049 chr1:7289937 CAMTA1 0.53 8.62 0.43 2.82e-16 Tourette's syndrome or obsessive-compulsive disorder; CRC cis rs7680126 0.632 rs6834645 chr4:10150174 G/A cg11266682 chr4:10021025 SLC2A9 -0.42 -6.17 -0.32 2.04e-9 Urate levels in lean individuals;Urate levels in overweight individuals;Urate levels in obese individuals; CRC cis rs4843747 0.518 rs4072777 chr16:88107030 G/A cg03395651 chr16:88107091 BANP 0.6 8.16 0.41 7.06e-15 Menopause (age at onset); CRC cis rs938554 0.577 rs4591605 chr4:10002719 T/C cg11266682 chr4:10021025 SLC2A9 0.4 6.25 0.33 1.3e-9 Blood metabolite levels; CRC cis rs1707322 0.721 rs28501477 chr1:46199084 A/G cg03146154 chr1:46216737 IPP 0.69 10.06 0.48 6.26e-21 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs6445967 0.898 rs4336086 chr3:58297390 C/T cg23715586 chr3:58305044 RPP14 0.35 5.84 0.31 1.25e-8 Platelet count; CRC cis rs2235649 0.833 rs9926962 chr16:1851826 A/G cg00935504 chr16:1863053 HAGH 0.3 5.65 0.3 3.44e-8 Blood metabolite levels; CRC cis rs4481887 1.000 rs6663817 chr1:248495613 A/G cg13385794 chr1:248469461 NA 0.39 6.74 0.35 7.28e-11 Common traits (Other); CRC cis rs743757 0.938 rs2236959 chr3:50441627 T/C cg08207895 chr3:50388901 TUSC4;CYB561D2 0.45 6.6 0.34 1.61e-10 Diastolic blood pressure; CRC cis rs6582630 0.555 rs1906260 chr12:38601013 T/G cg26384229 chr12:38710491 ALG10B 0.69 9.19 0.45 4.61e-18 Drug-induced liver injury (flucloxacillin); CRC cis rs1209950 1.000 rs1209950 chr21:40173528 A/G cg02119577 chr21:40195074 ETS2 0.38 6.48 0.34 3.31e-10 Non-small cell lung cancer (survival); CRC trans rs10983614 1.000 rs7867776 chr9:120072627 A/G cg14792983 chr20:18447909 C20orf12;POLR3F 0.46 6.12 0.32 2.6e-9 Survival in pancreatic cancer; CRC cis rs4713118 0.869 rs7776351 chr6:27726731 A/G cg03623178 chr6:28175578 NA -0.7 -9.95 -0.48 1.46e-20 Parkinson's disease; CRC cis rs10504229 0.636 rs72649133 chr8:58054681 G/A cg20607798 chr8:58055168 NA 0.55 6.19 0.32 1.82e-9 Developmental language disorder (linguistic errors); CRC cis rs3749237 0.576 rs4241406 chr3:49600426 C/T cg03060546 chr3:49711283 APEH 0.61 10.28 0.49 1.16e-21 Resting heart rate; CRC cis rs7827545 1.000 rs6992097 chr8:135565844 G/A cg13086574 chr8:135490821 ZFAT -0.36 -6.08 -0.32 3.34e-9 Hypertension (SNP x SNP interaction); CRC cis rs6479527 0.625 rs1933667 chr9:96744109 G/C cg13460858 chr9:96720652 NA 0.31 5.95 0.31 6.83e-9 Esophageal adenocarcinoma; CRC cis rs66887589 0.934 rs2389873 chr4:120554714 A/G cg09307838 chr4:120376055 NA -0.51 -7.86 -0.4 5.42e-14 Diastolic blood pressure; CRC cis rs9326248 0.652 rs7128382 chr11:117023487 A/C cg11861562 chr11:117069780 TAGLN 0.35 6.4 0.33 5.38e-10 Blood protein levels; CRC cis rs10479542 0.766 rs7733389 chr5:178974997 C/T cg00080972 chr5:178986291 RUFY1 0.36 6.8 0.35 4.82e-11 Lung cancer; CRC trans rs12310956 0.532 rs35366144 chr12:33992000 C/G cg26384229 chr12:38710491 ALG10B 0.51 6.46 0.34 3.72e-10 Morning vs. evening chronotype; CRC cis rs1451375 0.617 rs896307 chr7:50569060 T/C cg18232548 chr7:50535776 DDC -0.43 -5.61 -0.3 4.27e-8 Malaria; CRC cis rs11148252 0.904 rs9568732 chr13:52993412 A/G cg02158880 chr13:53174818 NA -0.49 -7.46 -0.38 7.58e-13 Lewy body disease; CRC cis rs4713118 0.666 rs2893930 chr6:27738806 T/C cg12172441 chr6:28176163 NA 0.6 6.56 0.34 2.1e-10 Parkinson's disease; CRC cis rs8141797 0.901 rs34247969 chr22:24555965 G/A cg20894457 chr22:24584366 SUSD2 0.67 6.98 0.36 1.59e-11 Amyotrophic lateral sclerosis;Coronary artery disease; CRC trans rs11098499 0.863 rs6534139 chr4:120449456 A/G cg25214090 chr10:38739885 LOC399744 -0.61 -9.43 -0.46 7.73e-19 Corneal astigmatism; CRC trans rs9747201 0.925 rs62078748 chr17:80055325 C/T cg07393940 chr7:158741817 NA -0.56 -7.84 -0.4 6.47e-14 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs9858542 0.953 rs6809216 chr3:49412559 G/A cg07274523 chr3:49395745 GPX1 0.45 6.05 0.32 4.03e-9 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC trans rs1005277 0.579 rs1740749 chr10:38521646 A/G cg17830980 chr10:43048298 ZNF37B -0.57 -9.68 -0.47 1.16e-19 Extrinsic epigenetic age acceleration; CRC cis rs10760158 0.800 rs4556152 chr9:124016909 G/A cg14417974 chr9:124058376 GSN -0.33 -5.66 -0.3 3.3e-8 Pulse pressure; CRC trans rs12478296 1.000 rs67535150 chr2:243046099 A/G cg18288967 chr1:45987694 PRDX1 0.66 7.29 0.37 2.3e-12 Obesity-related traits; CRC cis rs4654899 1.000 rs10799685 chr1:21465930 A/C cg02927042 chr1:21476669 EIF4G3 0.45 7.26 0.37 2.81e-12 Superior frontal gyrus grey matter volume; CRC cis rs7927592 0.913 rs11228287 chr11:68349754 A/G cg16797656 chr11:68205561 LRP5 0.36 5.73 0.3 2.27e-8 Total body bone mineral density; CRC cis rs9381040 0.655 rs2268193 chr6:41024625 A/G cg04346459 chr6:41068666 NFYA;LOC221442 -0.41 -6.14 -0.32 2.43e-9 Alzheimer's disease (late onset); CRC cis rs11764590 0.694 rs7797112 chr7:2085165 T/C cg14004847 chr7:1930337 MAD1L1 -0.43 -5.78 -0.3 1.73e-8 Neuroticism; CRC cis rs3931020 0.530 rs6668736 chr1:75234550 C/T cg00121533 chr1:75199117 CRYZ;TYW3 0.44 5.91 0.31 8.55e-9 Resistin levels; CRC cis rs10971721 0.643 rs12378415 chr9:33797333 G/T cg13495928 chr9:33750294 PRSS3 0.67 5.94 0.31 7.14e-9 Body mass index; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg03457587 chr19:54694791 MBOAT7;TSEN34 0.44 6.28 0.33 1.06e-9 Intelligence (multi-trait analysis); CRC cis rs853679 0.574 rs1233705 chr6:28166447 C/G cg12273811 chr6:28175739 NA 0.76 10.93 0.52 6.19e-24 Depression; CRC cis rs10971721 0.822 rs72727327 chr9:33918816 C/T cg13495928 chr9:33750294 PRSS3 0.56 5.97 0.31 6.15e-9 Body mass index; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg19138325 chr12:129429698 GLT1D1 -0.37 -6.08 -0.32 3.26e-9 Liver disease severity in Alagille syndrome; CRC cis rs9811920 0.609 rs793465 chr3:99627750 A/G cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G 0.46 6.18 0.32 1.87e-9 Axial length; CRC cis rs597539 0.652 rs622082 chr11:68703959 A/G cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.88 15.09 0.64 1.79e-39 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs4862750 1.000 rs4862750 chr4:187904043 C/T cg10295955 chr4:187884368 NA -1.05 -25.27 -0.81 4.48e-79 Lobe attachment (rater-scored or self-reported); CRC cis rs798554 0.679 rs2533877 chr7:2882421 G/A cg19346786 chr7:2764209 NA -0.39 -6.59 -0.34 1.73e-10 Height; CRC cis rs290268 0.585 rs290992 chr9:93561309 C/T cg02608019 chr9:93564028 SYK -0.44 -6.81 -0.35 4.61e-11 Platelet count; CRC cis rs7527798 0.592 rs10746386 chr1:207855095 C/T cg09232269 chr1:207846808 CR1L -0.45 -7.33 -0.37 1.84e-12 Erythrocyte sedimentation rate; CRC cis rs7666738 1.000 rs35066600 chr4:98991066 C/A cg03676636 chr4:99064102 C4orf37 0.23 6.32 0.33 8.59e-10 Colonoscopy-negative controls vs population controls; CRC cis rs4862750 0.872 rs6811569 chr4:187897988 A/G cg11301795 chr4:187892539 NA 0.86 19.01 0.72 6.63e-55 Lobe attachment (rater-scored or self-reported); CRC cis rs7552404 0.731 rs7523573 chr1:76372020 G/T cg10523679 chr1:76189770 ACADM 0.74 8.89 0.44 4.07e-17 Blood metabolite levels;Acylcarnitine levels; CRC cis rs1008375 1.000 rs10939738 chr4:17604295 G/C cg16339924 chr4:17578868 LAP3 0.47 6.32 0.33 8.36e-10 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs17067123 0.539 rs75564322 chr4:180066838 A/G cg26610307 chr4:180072759 NA -0.56 -6.74 -0.35 7.28e-11 Response to hepatitis C treatment; CRC cis rs7224685 0.501 rs7211478 chr17:3897178 C/T cg11204139 chr17:3907470 NA 0.83 16.53 0.67 4.27e-45 Type 2 diabetes; CRC cis rs3820068 0.581 rs72645861 chr1:15920314 A/G cg13390004 chr1:15929781 NA 0.5 6.88 0.35 3.01e-11 Systolic blood pressure; CRC cis rs7726839 0.540 rs3749615 chr5:601485 C/T cg17948913 chr5:572064 NA 0.51 5.86 0.31 1.1e-8 Obesity-related traits; CRC cis rs561341 0.941 rs17780086 chr17:30343282 G/A cg00745463 chr17:30367425 LRRC37B -0.88 -9.64 -0.47 1.51e-19 Hip circumference adjusted for BMI; CRC cis rs35762459 1 rs35762459 chr11:8844653 T/TA cg21881798 chr11:8931708 C11orf17;ST5 -0.56 -8.89 -0.44 4.2e-17 Immature fraction of reticulocytes; CRC trans rs11764590 0.715 rs55770986 chr7:2087823 T/C cg11693508 chr17:37793320 STARD3 0.57 6.66 0.34 1.17e-10 Neuroticism; CRC cis rs7607369 0.536 rs13013510 chr2:219667227 A/G cg02176678 chr2:219576539 TTLL4 -0.37 -5.92 -0.31 7.91e-9 Red blood cell count;Amyotrophic lateral sclerosis; CRC cis rs73001065 0.591 rs11668386 chr19:19531910 A/G cg03709012 chr19:19516395 GATAD2A 0.83 6.66 0.34 1.16e-10 LDL cholesterol; CRC trans rs75246769 0.636 rs74730677 chr7:145681220 G/C cg14916917 chr5:81574294 RPS23 0.91 6.2 0.32 1.7e-9 Facial morphology (factor 10, width of nasal floor); CRC cis rs11758351 0.660 rs2143345 chr6:26229148 C/T cg10723962 chr6:26240782 HIST1H4F -0.39 -6.43 -0.33 4.58e-10 Gout;Renal underexcretion gout; CRC trans rs1005277 0.579 rs2472175 chr10:38382901 T/G cg17830980 chr10:43048298 ZNF37B -0.6 -9.93 -0.48 1.67e-20 Extrinsic epigenetic age acceleration; CRC cis rs6502050 0.799 rs9911129 chr17:80087819 C/T cg11859384 chr17:80120422 CCDC57 -0.37 -5.92 -0.31 7.94e-9 Life satisfaction; CRC cis rs7412746 0.611 rs2228099 chr1:150808889 C/G cg15448220 chr1:150897856 SETDB1 0.42 6.0 0.31 5.2e-9 Melanoma; CRC cis rs2717559 0.542 rs10956986 chr8:143886601 C/T cg12516270 chr8:143859308 LYNX1 -0.69 -12.96 -0.58 2.57e-31 Urinary tract infection frequency; CRC cis rs62064224 0.791 rs2344977 chr17:30720573 C/G cg12855166 chr17:30846586 MYO1D -0.49 -7.62 -0.39 2.67e-13 Schizophrenia; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg04324509 chr3:101295624 PCNP -0.41 -6.77 -0.35 5.91e-11 Liver disease severity in Alagille syndrome; CRC trans rs8002861 0.935 rs7319725 chr13:44445421 T/C cg17145862 chr1:211918768 LPGAT1 0.74 14.82 0.63 2.04e-38 Leprosy; CRC cis rs7923609 0.967 rs3956912 chr10:65205881 C/T cg08743896 chr10:65200160 JMJD1C -0.42 -6.12 -0.32 2.62e-9 Educational attainment;Liver enzyme levels (alkaline phosphatase); CRC cis rs9969804 0.818 rs10992439 chr9:95495134 T/A cg14631576 chr9:95140430 CENPP -0.32 -5.97 -0.31 6.03e-9 Height; CRC cis rs1005277 0.540 rs4934907 chr10:38015230 A/C cg25517755 chr10:38738941 LOC399744 -0.45 -6.49 -0.34 3.24e-10 Extrinsic epigenetic age acceleration; CRC cis rs4819052 0.851 rs2838839 chr21:46667858 C/G cg11663144 chr21:46675770 NA 0.83 14.17 0.62 6.55e-36 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs5769707 0.632 rs6009782 chr22:50010812 C/G cg20744362 chr22:50050164 C22orf34 0.34 6.2 0.32 1.69e-9 Monocyte count;Monocyte percentage of white cells; CRC cis rs644799 1.000 rs651445 chr11:95539122 T/A cg03916912 chr11:95522834 CEP57;FAM76B 0.95 18.15 0.71 1.71e-51 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs67340775 0.541 rs169287 chr6:27854760 C/A cg08798685 chr6:27730294 NA -0.57 -6.27 -0.33 1.15e-9 Lung cancer in ever smokers; CRC trans rs9858542 1.000 rs13085791 chr3:49721798 C/A cg21665057 chr3:196295764 WDR53;FBXO45 -0.69 -9.02 -0.45 1.59e-17 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs4930103 0.935 rs4930101 chr11:2021859 G/T cg06197492 chr11:2016605 H19 0.42 6.58 0.34 1.81e-10 DNA methylation (parent-of-origin);DNA methylation (variation); CRC cis rs8072100 0.875 rs62073966 chr17:45600013 T/A cg08085267 chr17:45401833 C17orf57 0.67 10.79 0.51 2e-23 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs1023500 0.505 rs134888 chr22:42674281 C/T cg04733989 chr22:42467013 NAGA 0.4 5.77 0.3 1.79e-8 Schizophrenia; CRC cis rs73206853 0.841 rs4131851 chr12:110812345 T/C cg12870014 chr12:110450643 ANKRD13A 0.77 8.38 0.42 1.59e-15 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC cis rs755249 0.567 rs61779279 chr1:39837102 C/T cg18385671 chr1:39797026 MACF1 -0.4 -5.78 -0.3 1.74e-8 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs17376456 0.757 rs6859757 chr5:93206042 C/T cg25358565 chr5:93447407 FAM172A 1.07 9.71 0.47 9.45e-20 Diabetic retinopathy; CRC cis rs10256972 0.732 rs1574108 chr7:1105805 T/C cg16145915 chr7:1198662 ZFAND2A -0.31 -5.79 -0.3 1.61e-8 Longevity;Endometriosis; CRC cis rs16867321 0.950 rs4667223 chr2:181498302 C/G cg23363182 chr2:181467187 NA -0.51 -6.65 -0.34 1.21e-10 Obesity; CRC trans rs66759488 0.739 rs10851451 chr15:47608991 A/G cg09781304 chr17:80887954 TBCD -0.43 -6.05 -0.32 4.05e-9 Lung cancer; CRC cis rs73200209 0.744 rs56187732 chr12:116688042 C/T cg01776926 chr12:116560359 MED13L -0.61 -7.28 -0.37 2.56e-12 Total body bone mineral density; CRC cis rs2276314 0.857 rs7237599 chr18:33639396 T/C cg19628046 chr18:33552617 C18orf21 0.58 8.36 0.42 1.79e-15 Endometriosis;Drug-induced torsades de pointes; CRC cis rs17095355 1.000 rs17095355 chr10:111735750 C/T cg00817464 chr10:111662876 XPNPEP1 -0.62 -8.44 -0.42 1.06e-15 Biliary atresia; CRC trans rs4824093 0.610 rs2208023 chr22:50249983 A/G cg09872104 chr7:134855509 C7orf49 -0.84 -7.34 -0.38 1.66e-12 Amyotrophic lateral sclerosis (sporadic); CRC cis rs7208859 0.623 rs3794796 chr17:29130880 G/C cg01831904 chr17:28903510 LRRC37B2 -0.66 -6.78 -0.35 5.45e-11 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs35146811 0.657 rs36019559 chr7:99814586 A/G cg13334819 chr7:99746414 C7orf59 0.51 6.71 0.35 8.67e-11 Coronary artery disease; CRC cis rs736408 0.609 rs2230534 chr3:52802402 A/C cg18404041 chr3:52824283 ITIH1 -0.43 -8.72 -0.43 1.36e-16 Bipolar disorder; CRC cis rs9549328 0.756 rs2993291 chr13:113653846 C/T cg24588162 chr13:113633484 MCF2L -0.36 -5.72 -0.3 2.46e-8 Systolic blood pressure; CRC cis rs9768139 0.708 rs896781 chr7:158114114 T/C cg23298862 chr7:158159286 PTPRN2 0.37 5.88 0.31 9.96e-9 Calcium levels; CRC cis rs9905704 0.918 rs12949138 chr17:56934865 A/C cg12560992 chr17:57184187 TRIM37 0.55 7.74 0.39 1.2e-13 Testicular germ cell tumor; CRC cis rs10046574 0.831 rs7455447 chr7:135062056 C/T cg27474649 chr7:135195673 CNOT4 0.66 5.64 0.3 3.64e-8 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs2882667 0.861 rs10037106 chr5:138365490 G/T cg04439458 chr5:138467593 SIL1 -0.33 -5.99 -0.31 5.44e-9 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs11105298 0.891 rs10858906 chr12:89934474 C/T cg00757033 chr12:89920650 WDR51B 0.38 6.22 0.32 1.55e-9 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; CRC cis rs13108904 0.870 rs13124876 chr4:1247955 T/C cg16405210 chr4:1374714 KIAA1530 -0.44 -6.18 -0.32 1.93e-9 Obesity-related traits; CRC cis rs6426558 0.537 rs1320494 chr1:227241300 A/T cg10327440 chr1:227177885 CDC42BPA 0.46 6.82 0.35 4.28e-11 Neutrophil percentage of white cells; CRC cis rs853679 0.517 rs9393897 chr6:28127710 G/T cg03623178 chr6:28175578 NA 0.98 12.66 0.57 3.31e-30 Depression; CRC cis rs6665290 0.904 rs1045287 chr1:227178962 C/T cg10327440 chr1:227177885 CDC42BPA 1.04 22.99 0.79 2.02e-70 Myeloid white cell count; CRC cis rs17270561 0.636 rs7754814 chr6:25745243 A/T cg17691542 chr6:26056736 HIST1H1C 0.72 9.24 0.45 3.07e-18 Iron status biomarkers; CRC cis rs7103648 0.569 rs11039266 chr11:47532395 T/G cg20307385 chr11:47447363 PSMC3 0.82 11.79 0.55 5.2e-27 Diastolic blood pressure;Systolic blood pressure; CRC cis rs4665809 0.877 rs35224700 chr2:26298037 T/C cg25036284 chr2:26402008 FAM59B 0.54 6.41 0.33 5.04e-10 Gut microbiome composition (summer); CRC cis rs16975963 0.604 rs17305326 chr19:38119547 T/C cg15135657 chr19:38346511 NA -0.46 -6.28 -0.33 1.04e-9 Longevity; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg02114728 chr2:169102929 STK39 0.44 6.16 0.32 2.15e-9 Response to antipsychotic treatment; CRC cis rs6831352 0.734 rs1154400 chr4:100010010 C/T cg12011299 chr4:100065546 ADH4 0.45 8.7 0.43 1.65e-16 Alcohol dependence; CRC cis rs1046896 0.538 rs3803771 chr17:80687758 G/A cg19500275 chr17:80737654 TBCD -0.51 -8.5 -0.42 6.82e-16 Glycated hemoglobin levels; CRC cis rs1552244 0.935 rs7652190 chr3:10105150 G/A cg08888203 chr3:10149979 C3orf24 0.73 9.99 0.48 1.03e-20 Alzheimer's disease; CRC cis rs4713118 0.513 rs149941 chr6:28001033 T/C cg15786705 chr6:28176104 NA 0.6 8.79 0.44 8.25e-17 Parkinson's disease; CRC cis rs12477438 0.520 rs1044575 chr2:99812070 G/A cg14399236 chr2:99771627 LIPT1;TSGA10 0.77 13.38 0.59 6.48e-33 Chronic sinus infection; CRC cis rs7949030 0.596 rs11231138 chr11:62316195 C/G cg22862634 chr11:62369728 EML3;MTA2 0.59 10.55 0.5 1.29e-22 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; CRC cis rs6840360 0.571 rs4696276 chr4:152532682 G/A cg09659197 chr4:152720779 NA 0.31 5.66 0.3 3.23e-8 Intelligence (multi-trait analysis); CRC cis rs798554 0.759 rs2644309 chr7:2889034 T/C cg17321639 chr7:2759063 NA -0.48 -6.13 -0.32 2.58e-9 Height; CRC cis rs3751196 0.808 rs17034662 chr12:104221904 A/G cg02344784 chr12:104178138 NT5DC3 0.68 7.18 0.37 4.7e-12 Sense of smell; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg07120806 chr4:1873451 WHSC1 0.42 6.63 0.34 1.37e-10 Liver disease severity in Alagille syndrome; CRC cis rs2032447 0.714 rs199739 chr6:25960509 A/C cg12588279 chr6:26043732 HIST1H2BB 0.44 6.29 0.33 9.84e-10 Intelligence (multi-trait analysis); CRC cis rs4713118 0.866 rs2179094 chr6:27741825 T/C cg21251018 chr6:28226885 NKAPL 0.42 6.05 0.32 3.84e-9 Parkinson's disease; CRC cis rs6088580 0.601 rs6059872 chr20:33082775 C/A cg24642439 chr20:33292090 TP53INP2 0.39 6.53 0.34 2.53e-10 Glomerular filtration rate (creatinine); CRC cis rs2836974 0.831 rs34592564 chr21:40516288 G/C cg11890956 chr21:40555474 PSMG1 1.0 15.36 0.65 1.68e-40 Cognitive function; CRC cis rs9916302 0.706 rs597069 chr17:37458512 G/T cg07936489 chr17:37558343 FBXL20 0.85 9.91 0.48 2.03e-20 Glomerular filtration rate (creatinine); CRC cis rs6495122 0.699 rs2168518 chr15:75081078 G/A cg14664628 chr15:75095509 CSK -0.69 -11.3 -0.53 3.08e-25 Caffeine consumption;Diastolic blood pressure;Coffee consumption; CRC cis rs477895 0.713 rs67546972 chr11:63962162 G/A cg23719950 chr11:63933701 MACROD1 -0.67 -8.63 -0.43 2.76e-16 Mean platelet volume; CRC cis rs35110281 0.715 rs8129601 chr21:45119104 A/G cg04455712 chr21:45112962 RRP1B 0.4 7.68 0.39 1.85e-13 Mean corpuscular volume; CRC cis rs6951245 0.744 rs10265736 chr7:1172465 C/T cg22907277 chr7:1156413 C7orf50 0.76 8.78 0.44 9.43e-17 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs7147624 1.000 rs10873192 chr14:66110653 A/G cg03016385 chr14:66212404 NA -1.03 -10.56 -0.5 1.18e-22 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs10504229 1.000 rs75037501 chr8:58170136 T/G cg24829409 chr8:58192753 C8orf71 -0.68 -11.34 -0.53 2.27e-25 Developmental language disorder (linguistic errors); CRC cis rs6123683 0.964 rs8116259 chr20:55826168 A/G cg13236649 chr20:55835020 BMP7 0.43 6.21 0.32 1.6e-9 Facial morphology (factor 5, width of mouth relative to central midface); CRC cis rs875971 0.862 rs6971059 chr7:66067032 A/G cg18252515 chr7:66147081 NA 0.43 6.12 0.32 2.62e-9 Aortic root size; CRC cis rs6546324 0.615 rs7598280 chr2:67815313 A/T cg15745817 chr2:67799979 NA -0.55 -9.24 -0.45 3.14e-18 Endometriosis; CRC cis rs2153535 0.580 rs9379216 chr6:8481235 G/A cg07606381 chr6:8435919 SLC35B3 0.68 10.89 0.51 8.84e-24 Motion sickness; CRC trans rs3780486 0.846 rs10758192 chr9:33131651 G/A cg04842962 chr6:43655489 MRPS18A 1.16 25.92 0.82 1.73e-81 IgG glycosylation; CRC cis rs6502050 0.835 rs8081949 chr17:80117490 G/A cg09264619 chr17:80180166 NA -0.35 -5.98 -0.31 5.97e-9 Life satisfaction; CRC cis rs2732480 0.557 rs2732454 chr12:48719677 T/C cg21466736 chr12:48725269 NA -0.6 -9.02 -0.45 1.63e-17 Hemoglobin concentration;Red blood cell count;Hematocrit; CRC cis rs2836974 0.931 rs13625 chr21:40669083 G/T cg11644478 chr21:40555479 PSMG1 0.78 11.66 0.54 1.58e-26 Cognitive function; CRC cis rs929596 0.583 rs77070100 chr2:234587847 T/C cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.45 -7.11 -0.36 7.49e-12 Total bilirubin levels in HIV-1 infection; CRC trans rs8002861 0.905 rs12875052 chr13:44449368 G/C cg12856521 chr11:46389249 DGKZ -0.41 -6.53 -0.34 2.49e-10 Leprosy; CRC cis rs7647973 1.000 rs4241407 chr3:49600319 C/T cg20833759 chr3:49053208 WDR6;DALRD3 0.55 8.36 0.42 1.74e-15 Menarche (age at onset); CRC cis rs2769264 0.546 rs12047617 chr1:151392597 G/A cg18801370 chr1:151430492 POGZ 0.57 6.62 0.34 1.48e-10 Blood trace element (Cu levels); CRC cis rs939584 0.825 rs62105327 chr2:639060 T/A cg03610516 chr2:642275 NA 0.42 5.64 0.3 3.67e-8 Body mass index; CRC cis rs9443645 0.869 rs6913028 chr6:79513590 C/T cg05283184 chr6:79620031 NA -0.57 -9.04 -0.45 1.38e-17 Intelligence (multi-trait analysis); CRC cis rs10504229 0.595 rs116490935 chr8:58117531 A/G cg04204079 chr8:58130323 NA -0.45 -5.74 -0.3 2.18e-8 Developmental language disorder (linguistic errors); CRC cis rs34172651 0.502 rs12930727 chr16:24838497 G/T cg02428538 chr16:24856791 SLC5A11 0.45 6.13 0.32 2.56e-9 Intelligence (multi-trait analysis); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg16595404 chr10:12238160 CDC123;NUDT5 0.46 6.62 0.34 1.5e-10 Response to antipsychotic treatment; CRC cis rs7917772 0.503 rs7100753 chr10:104300979 C/T cg11453585 chr10:104263688 ACTR1A;SUFU 0.91 17.49 0.69 6.57e-49 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC cis rs7618501 0.633 rs12496973 chr3:50002245 T/C cg24110177 chr3:50126178 RBM5 -0.5 -7.88 -0.4 4.98e-14 Intelligence (multi-trait analysis); CRC cis rs6502050 0.605 rs35158616 chr17:80094480 A/G cg22110888 chr17:80059540 CCDC57 0.4 6.29 0.33 9.88e-10 Life satisfaction; CRC cis rs2836633 0.929 rs2836610 chr21:40044502 C/T cg12884169 chr21:40033163 ERG 0.41 9.16 0.45 5.88e-18 Coronary artery disease; CRC cis rs7487075 0.619 rs2220727 chr12:46805069 G/A cg22049899 chr12:47219821 SLC38A4 0.31 5.67 0.3 3.17e-8 Itch intensity from mosquito bite; CRC cis rs2115630 0.967 rs8027779 chr15:85255385 T/C cg12501888 chr15:85177176 SCAND2 -0.37 -5.94 -0.31 7.09e-9 P wave terminal force; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg11203927 chr22:41032991 MKL1 0.41 5.96 0.31 6.36e-9 Intelligence (multi-trait analysis); CRC cis rs7833986 0.534 rs72653924 chr8:56906088 C/T cg23139584 chr8:56987506 RPS20;SNORD54 0.79 11.41 0.53 1.23e-25 Height; CRC cis rs2952156 0.920 rs2517951 chr17:37853097 C/T cg00129232 chr17:37814104 STARD3 -0.75 -13.39 -0.59 5.94e-33 Asthma; CRC cis rs9457247 0.529 rs6907666 chr6:167523395 A/G cg07741184 chr6:167504864 NA -0.4 -6.93 -0.36 2.29e-11 Crohn's disease; CRC cis rs7811142 0.830 rs7341507 chr7:99951315 A/G cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.91 12.51 0.57 1.24e-29 Platelet count; CRC cis rs2204008 0.837 rs11168504 chr12:37964922 G/T cg26384229 chr12:38710491 ALG10B 0.67 8.7 0.43 1.67e-16 Bladder cancer; CRC cis rs2880765 0.525 rs2062234 chr15:86054490 A/G cg10818794 chr15:86012489 AKAP13 -0.48 -7.14 -0.37 5.88e-12 Coronary artery disease; CRC cis rs6860806 0.531 rs272888 chr5:131665423 T/C cg11843238 chr5:131593191 PDLIM4 0.42 7.2 0.37 4.06e-12 Breast cancer; CRC cis rs2197308 0.765 rs12824529 chr12:37931656 T/C cg13010199 chr12:38710504 ALG10B 0.44 5.62 0.3 4.08e-8 Morning vs. evening chronotype; CRC cis rs9916302 0.904 rs4795359 chr17:37573146 C/T cg03013999 chr17:37608204 MED1 0.47 7.35 0.38 1.61e-12 Glomerular filtration rate (creatinine); CRC cis rs2070488 0.804 rs13094715 chr3:38504430 G/A cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.79 13.72 0.6 3.52e-34 Electrocardiographic conduction measures; CRC cis rs3749237 0.595 rs2878298 chr3:49406080 T/C cg02487422 chr3:49467188 NICN1 0.42 6.89 0.35 2.9100000000000002e-11 Resting heart rate; CRC cis rs11122272 0.735 rs2808601 chr1:231536571 A/G cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.54 -8.03 -0.4 1.73e-14 Hemoglobin concentration; CRC cis rs9522267 0.535 rs9522286 chr13:112230909 A/G cg10483660 chr13:112241077 NA -0.47 -8.67 -0.43 1.97e-16 Hepatitis; CRC cis rs2354432 0.607 rs6685775 chr1:146744294 A/G cg25205988 chr1:146714368 CHD1L -1.24 -9.92 -0.48 1.84e-20 Mitochondrial DNA levels; CRC cis rs644799 0.930 rs587123 chr11:95560539 T/G cg25478527 chr11:95522999 CEP57;FAM76B 0.52 7.86 0.4 5.6e-14 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC trans rs7944735 0.690 rs7927682 chr11:47947658 T/C cg03929089 chr4:120376271 NA 0.53 6.26 0.33 1.22e-9 Intraocular pressure; CRC cis rs1552244 0.554 rs6768339 chr3:10006079 G/T cg16606324 chr3:10149918 C3orf24 -0.49 -7.32 -0.37 1.93e-12 Alzheimer's disease; CRC cis rs4481887 0.861 rs10788776 chr1:248479177 T/C cg13385794 chr1:248469461 NA 0.4 7.05 0.36 1.06e-11 Common traits (Other); CRC cis rs2252790 0.605 rs12193974 chr6:116542500 T/C cg26893134 chr6:116381904 FRK 0.23 5.64 0.3 3.74e-8 Fast beta electroencephalogram; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg15334456 chr3:10290272 TATDN2 -0.41 -6.2 -0.32 1.66e-9 Myopia (pathological); CRC cis rs7692995 1.000 rs1380293 chr4:18027235 T/C cg08925142 chr4:18023851 LCORL -0.53 -5.97 -0.31 6.12e-9 Height; CRC cis rs9660992 0.547 rs12143121 chr1:205199142 A/G cg00857998 chr1:205179979 DSTYK 0.44 5.82 0.31 1.37e-8 Mean corpuscular volume;Mean platelet volume; CRC cis rs4654899 0.758 rs6694455 chr1:21352185 C/T cg02927042 chr1:21476669 EIF4G3 -0.4 -6.35 -0.33 7.1e-10 Superior frontal gyrus grey matter volume; CRC cis rs17539620 0.624 rs111484697 chr6:154838903 A/G cg20019720 chr6:154832845 CNKSR3 0.47 7.24 0.37 3.15e-12 Lipoprotein (a) levels; CRC cis rs875971 0.545 rs67397473 chr7:65633305 A/G cg03233332 chr7:66118400 NA -0.44 -6.32 -0.33 8.49e-10 Aortic root size; CRC cis rs2404602 0.608 rs12439484 chr15:76602937 A/C cg00316803 chr15:76480434 C15orf27 -0.4 -6.84 -0.35 3.83e-11 Blood metabolite levels; CRC cis rs11148252 0.532 rs9526975 chr13:53255804 C/T cg12458913 chr13:53173898 NA 0.9 17.04 0.68 4.06e-47 Lewy body disease; CRC cis rs798554 1.000 rs798550 chr7:2760609 A/G cg19717773 chr7:2847554 GNA12 -0.43 -6.5 -0.34 2.99e-10 Height; CRC cis rs17401966 0.838 rs11580854 chr1:10293565 G/A cg19773385 chr1:10388646 KIF1B -0.64 -10.41 -0.5 4.11e-22 Hepatocellular carcinoma; CRC cis rs7680126 0.644 rs62288518 chr4:10087464 T/C cg11266682 chr4:10021025 SLC2A9 -0.38 -5.87 -0.31 1.07e-8 Urate levels in lean individuals;Urate levels in overweight individuals;Urate levels in obese individuals; CRC cis rs4711350 1.000 rs2182659 chr6:33751767 A/G cg07979401 chr6:33739406 LEMD2 -0.47 -5.89 -0.31 9.76e-9 Schizophrenia; CRC cis rs12431939 1.000 rs60818073 chr14:51696649 T/C cg23942311 chr14:51606299 NA -0.54 -6.24 -0.33 1.34e-9 Cancer; CRC cis rs1559088 0.947 rs7259879 chr19:33549462 T/C cg27124370 chr19:33622961 WDR88 0.4 5.63 0.3 3.78e-8 Bone ultrasound measurement (broadband ultrasound attenuation); CRC cis rs243505 1.000 rs243520 chr7:148423560 C/T cg09806900 chr7:148480153 CUL1 -0.46 -6.51 -0.34 2.74e-10 Inflammatory bowel disease;Crohn's disease; CRC cis rs5769765 0.955 rs6520066 chr22:50294988 C/T cg04121214 chr22:50244548 NA 0.4 6.12 0.32 2.63e-9 Schizophrenia; CRC cis rs3733585 0.699 rs1122142 chr4:9947548 G/C cg11266682 chr4:10021025 SLC2A9 -0.46 -9.29 -0.46 2.19e-18 Cleft plate (environmental tobacco smoke interaction); CRC cis rs172166 0.694 rs203884 chr6:28077374 G/T cg10876282 chr6:28092338 ZSCAN16 0.45 6.08 0.32 3.26e-9 Cardiac Troponin-T levels; CRC cis rs7762018 0.621 rs3823465 chr6:170068180 A/G cg19338460 chr6:170058176 WDR27 -0.54 -6.18 -0.32 1.86e-9 Thiazide-induced adverse metabolic effects in hypertensive patients; CRC cis rs9300255 0.722 rs34997336 chr12:123829116 G/A cg00376283 chr12:123451042 ABCB9 -0.54 -7.18 -0.37 4.78e-12 Neutrophil percentage of white cells; CRC cis rs1552244 1.000 rs57631744 chr3:10118962 T/C cg18598329 chr3:10140678 FANCD2;C3orf24 -0.9 -12.84 -0.58 7.52e-31 Alzheimer's disease; CRC cis rs7119 0.717 rs12917314 chr15:77818285 T/C cg27398640 chr15:77910606 LINGO1 -0.43 -7.47 -0.38 7.13e-13 Type 2 diabetes; CRC cis rs4662945 0.525 rs10174479 chr2:130296287 A/C cg05962382 chr2:130345044 NA -0.46 -7.91 -0.4 3.96e-14 Response to cytidine analogues (gemcitabine); CRC cis rs6879260 1.000 rs7725605 chr5:179732678 T/G cg23221052 chr5:179740743 GFPT2 -0.66 -10.42 -0.5 3.82e-22 Height; CRC trans rs8073060 0.544 rs1080352 chr17:34002362 A/G cg19694781 chr19:47549865 TMEM160 -1.07 -14.34 -0.62 1.5e-36 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; CRC cis rs796364 0.806 rs11679676 chr2:201040981 C/T cg25936922 chr2:200820526 C2orf60;C2orf47 -0.66 -5.76 -0.3 1.93e-8 Schizophrenia; CRC cis rs6570726 0.791 rs10872577 chr6:145900560 G/T cg13319975 chr6:146136371 FBXO30 -0.42 -6.19 -0.32 1.75e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs2976388 0.609 rs2572909 chr8:143806464 C/G cg24046110 chr8:143859143 LYNX1 0.48 8.32 0.42 2.3e-15 Urinary tract infection frequency; CRC cis rs10504229 1.000 rs61733801 chr8:58192513 A/G cg22535103 chr8:58192502 C8orf71 -0.82 -12.27 -0.56 9.63e-29 Developmental language disorder (linguistic errors); CRC cis rs67478160 0.619 rs10083370 chr14:104314182 G/A cg08213375 chr14:104286397 PPP1R13B -0.64 -13.32 -0.59 1.1e-32 Schizophrenia; CRC cis rs736801 0.808 rs2522057 chr5:131801947 C/G cg00255919 chr5:131827918 IRF1 -0.34 -5.74 -0.3 2.13e-8 Breast cancer;Mosquito bite size; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg07866137 chr8:67579786 VCPIP1 0.46 6.11 0.32 2.85e-9 Thyroid stimulating hormone; CRC cis rs7659604 1.000 rs10016433 chr4:122664771 A/G cg19748678 chr4:122722346 EXOSC9 0.54 8.55 0.43 4.7e-16 Type 2 diabetes; CRC cis rs1552244 0.872 rs6771931 chr3:10113408 C/G cg18598329 chr3:10140678 FANCD2;C3orf24 -0.88 -12.26 -0.56 1.03e-28 Alzheimer's disease; CRC cis rs9372498 0.536 rs55899435 chr6:118812099 C/T cg01339444 chr6:118972232 C6orf204 0.52 5.92 0.31 8.31e-9 Diastolic blood pressure; CRC cis rs6693567 0.545 rs12049177 chr1:150474337 G/A cg15654264 chr1:150340011 RPRD2 0.4 5.87 0.31 1.07e-8 Migraine; CRC trans rs7395662 0.963 rs7125110 chr11:48545507 G/A cg21153622 chr11:89784906 NA -0.45 -7.18 -0.37 4.68e-12 HDL cholesterol; CRC cis rs12325245 0.536 rs12924708 chr16:58567643 G/A cg02549819 chr16:58548995 SETD6 1.13 7.37 0.38 1.43e-12 Schizophrenia; CRC cis rs11758351 0.866 rs77205516 chr6:26205356 T/A cg22723502 chr6:26240528 HIST1H4F -0.39 -6.33 -0.33 8.03e-10 Gout;Renal underexcretion gout; CRC cis rs6088580 0.602 rs6059840 chr20:33030405 G/A cg08999081 chr20:33150536 PIGU 0.61 11.57 0.54 3.44e-26 Glomerular filtration rate (creatinine); CRC cis rs1997103 0.906 rs2177806 chr7:55402609 A/T cg17469321 chr7:55412551 NA 0.73 11.31 0.53 2.87e-25 QRS interval (sulfonylurea treatment interaction); CRC cis rs2836974 0.863 rs8128026 chr21:40533702 T/C cg17971929 chr21:40555470 PSMG1 0.81 11.89 0.55 2.36e-27 Cognitive function; CRC cis rs2013441 0.932 rs3850785 chr17:20185248 A/G cg13482628 chr17:19912719 NA -0.4 -6.29 -0.33 1.04e-9 Obesity-related traits; CRC cis rs12519773 0.526 rs4632783 chr5:92528309 A/G cg18783429 chr5:92414398 NA 0.27 5.8 0.3 1.58e-8 Migraine; CRC trans rs2727020 0.590 rs7949936 chr11:49378902 G/A cg03929089 chr4:120376271 NA -0.65 -8.05 -0.41 1.49e-14 Coronary artery disease; CRC cis rs7618915 0.547 rs68021750 chr3:52624769 G/A cg18099408 chr3:52552593 STAB1 -0.44 -7.27 -0.37 2.7e-12 Bipolar disorder; CRC cis rs9916302 0.904 rs7501488 chr17:37576417 T/G cg00129232 chr17:37814104 STARD3 -0.54 -8.12 -0.41 9.26e-15 Glomerular filtration rate (creatinine); CRC cis rs4474465 0.736 rs4945291 chr11:78254413 C/T cg27205649 chr11:78285834 NARS2 0.49 6.26 0.33 1.22e-9 Alzheimer's disease (survival time); CRC cis rs2777491 0.522 rs7173571 chr15:41712807 T/C cg18705301 chr15:41695430 NDUFAF1 -0.43 -6.87 -0.35 3.15e-11 Ulcerative colitis; CRC cis rs7605827 0.808 rs13001585 chr2:15517790 T/C cg19274914 chr2:15703543 NA 0.39 5.93 0.31 7.51e-9 Educational attainment (years of education); CRC cis rs77956314 0.711 rs4767492 chr12:117436861 C/T cg02017074 chr12:117425053 FBXW8 0.65 5.6 0.3 4.41e-8 Subcortical brain region volumes;Hippocampal volume; CRC cis rs73206853 0.841 rs73194013 chr12:111100677 T/C cg12870014 chr12:110450643 ANKRD13A 0.79 8.35 0.42 1.94e-15 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC cis rs13082711 0.911 rs4973772 chr3:27450234 G/T cg02860705 chr3:27208620 NA 0.6 8.47 0.42 8.42e-16 Systolic blood pressure;Diastolic blood pressure;Blood pressure; CRC cis rs12594515 1.000 rs7173144 chr15:45991196 A/G cg22117107 chr15:45993392 NA -0.45 -9.16 -0.45 5.85e-18 Waist circumference;Weight; CRC cis rs7927771 0.864 rs3781626 chr11:47442893 A/T cg20135002 chr11:47629003 NA -0.35 -5.89 -0.31 9.33e-9 Subjective well-being; CRC cis rs870825 0.929 rs72689272 chr4:185592515 T/C cg04058563 chr4:185651563 MLF1IP 0.63 6.64 0.34 1.29e-10 Blood protein levels; CRC cis rs1552244 0.572 rs17032426 chr3:10167112 G/A cg10729496 chr3:10149963 C3orf24 0.48 5.61 0.3 4.19e-8 Alzheimer's disease; CRC cis rs7731657 0.537 rs2107334 chr5:130292773 T/C cg08523029 chr5:130500466 HINT1 -0.49 -6.19 -0.32 1.83e-9 Fasting plasma glucose; CRC cis rs7827545 1.000 rs7846013 chr8:135569967 C/T cg17885191 chr8:135476712 NA 0.41 5.8 0.3 1.56e-8 Hypertension (SNP x SNP interaction); CRC cis rs425277 1.000 rs55826501 chr1:2059143 G/A cg24578937 chr1:2090814 PRKCZ 0.67 11.72 0.54 9.53e-27 Height; CRC cis rs2298450 1.000 rs2298450 chr21:37623447 C/T cg02919814 chr21:37666008 DOPEY2 -0.4 -5.97 -0.31 6.32e-9 Schizophrenia; CRC cis rs5769765 0.908 rs9616376 chr22:50310829 A/G cg08270630 chr22:50330655 NA -0.4 -5.63 -0.3 3.78e-8 Schizophrenia; CRC cis rs13256369 0.760 rs7816171 chr8:8575835 T/C cg18904891 chr8:8559673 CLDN23 0.52 7.12 0.37 6.7e-12 Obesity-related traits; CRC cis rs7236492 0.515 rs8086051 chr18:77173158 C/T cg15644404 chr18:77186268 NFATC1 -0.83 -6.41 -0.33 5.05e-10 Inflammatory bowel disease;Crohn's disease; CRC cis rs524281 0.861 rs2889313 chr11:65966066 G/C cg16950941 chr11:66035639 RAB1B -0.62 -7.59 -0.39 3.28e-13 Electroencephalogram traits; CRC cis rs58688157 0.880 rs12272314 chr11:590648 A/G cg01842473 chr11:617407 IRF7;MUPCDH -0.66 -8.96 -0.44 2.38e-17 Systemic lupus erythematosus; CRC cis rs11758351 0.587 rs16891466 chr6:26235737 G/A cg10723962 chr6:26240782 HIST1H4F -0.39 -6.14 -0.32 2.44e-9 Gout;Renal underexcretion gout; CRC cis rs172166 0.694 rs203892 chr6:28067196 T/C cg02631126 chr6:28058918 ZSCAN12L1 0.24 5.69 0.3 2.82e-8 Cardiac Troponin-T levels; CRC cis rs3617 0.625 rs2071042 chr3:52864584 A/G cg15147215 chr3:52552868 STAB1 -0.53 -9.22 -0.45 3.79e-18 Red blood cell count;Autism spectrum disorder or schizophrenia; CRC cis rs8032158 0.963 rs12102020 chr15:56125578 G/A cg02198044 chr15:56286336 NEDD4 -0.39 -6.04 -0.32 4.06e-9 Keloid; CRC cis rs4665809 1.000 rs4665819 chr2:26309073 A/G cg04944784 chr2:26401820 FAM59B -0.6 -7.77 -0.39 1.01e-13 Gut microbiome composition (summer); CRC cis rs2067615 0.524 rs7309351 chr12:107077432 C/T cg15890332 chr12:107067104 RFX4 -0.32 -5.62 -0.3 4.02e-8 Heart rate; CRC cis rs2836974 0.897 rs7280375 chr21:40552408 C/T cg06238570 chr21:40685208 BRWD1 -0.77 -10.76 -0.51 2.5e-23 Cognitive function; CRC cis rs6866344 0.570 rs1071881 chr5:178135917 C/T cg10224037 chr5:178157518 ZNF354A 0.77 11.59 0.54 2.75e-26 Neutrophil percentage of white cells; CRC cis rs11098499 0.954 rs6822679 chr4:120402702 A/C cg24375607 chr4:120327624 NA 0.49 7.67 0.39 2.01e-13 Corneal astigmatism; CRC cis rs826838 0.967 rs1719856 chr12:39127201 C/T cg26384229 chr12:38710491 ALG10B -0.64 -9.57 -0.47 2.61e-19 Heart rate; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg01560739 chr3:32023198 OSBPL10;ZNF860 -0.39 -5.98 -0.31 5.78e-9 Myopia (pathological); CRC cis rs9858542 0.903 rs17080528 chr3:49389842 C/T cg03060546 chr3:49711283 APEH -0.49 -6.88 -0.35 2.98e-11 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs7264396 0.790 rs2425125 chr20:34330954 A/G cg04508476 chr20:34239394 CPNE1;RBM12 0.63 10.27 0.49 1.21e-21 Total cholesterol levels; CRC cis rs11792861 0.962 rs3750454 chr9:111801325 C/G cg05043794 chr9:111880884 C9orf5 0.34 6.24 0.33 1.36e-9 Menarche (age at onset); CRC cis rs10256972 0.591 rs6968988 chr7:1169619 A/G cg07308232 chr7:1071921 C7orf50 -0.47 -6.57 -0.34 1.95e-10 Longevity;Endometriosis; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg12128876 chr20:46131028 NCOA3 0.4 6.24 0.33 1.36e-9 Liver disease severity in Alagille syndrome; CRC cis rs2933343 1.000 rs1680795 chr3:128620388 T/C cg11901034 chr3:128598214 ACAD9 -0.53 -6.27 -0.33 1.13e-9 IgG glycosylation; CRC cis rs6662572 0.737 rs4660901 chr1:46445257 G/A cg03123370 chr1:45965343 CCDC163P;MMACHC -0.44 -5.7 -0.3 2.71e-8 Blood protein levels; CRC cis rs6690583 0.697 rs10782537 chr1:85484473 C/T cg11262906 chr1:85462892 MCOLN2 -0.51 -7.71 -0.39 1.5e-13 Serum sulfate level; CRC cis rs11628318 0.614 rs1190342 chr14:103100382 C/T cg08075719 chr14:103021372 NA -0.68 -7.94 -0.4 3.23e-14 Platelet count; CRC trans rs8123881 0.733 rs7268466 chr20:15810676 C/T cg09414045 chr1:110162465 AMPD2 0.56 6.44 0.33 4.16e-10 Body mass index; CRC cis rs10464366 0.544 rs12668821 chr7:39167846 T/A cg18850127 chr7:39170497 POU6F2 0.58 7.65 0.39 2.27e-13 IgG glycosylation; CRC cis rs881375 0.967 rs1008382 chr9:123681255 C/G cg14255062 chr9:123606675 PSMD5;LOC253039 0.42 6.16 0.32 2.16e-9 Rheumatoid arthritis; CRC cis rs6089584 0.927 rs2296081 chr20:60572663 G/T cg13770153 chr20:60521292 NA -0.57 -9.47 -0.46 5.6e-19 Body mass index; CRC cis rs10504229 0.683 rs7460059 chr8:58111561 C/T cg04204079 chr8:58130323 NA -0.46 -5.84 -0.31 1.22e-8 Developmental language disorder (linguistic errors); CRC cis rs769267 0.965 rs1010207 chr19:19416045 T/C cg02546618 chr19:19431379 KIAA0892;SF4 0.46 6.3 0.33 9.47e-10 Tonsillectomy; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg03311606 chr2:173292277 ITGA6 0.46 6.33 0.33 7.82e-10 Response to antipsychotic treatment; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg00388479 chr19:47354305 AP2S1 0.5 7.03 0.36 1.16e-11 Response to antipsychotic treatment; CRC trans rs634534 0.622 rs1192168 chr11:65730945 T/G cg17712092 chr4:129076599 LARP1B 0.61 9.99 0.48 1.05e-20 Sum eosinophil basophil counts;Eosinophil counts; CRC cis rs62103177 0.733 rs62096748 chr18:77619699 T/C cg12964065 chr18:77638022 KCNG2 0.62 6.64 0.34 1.27e-10 Opioid sensitivity; CRC cis rs747650 0.892 rs1976143 chr11:47225534 G/A cg19486271 chr11:47235900 DDB2 -0.51 -7.71 -0.39 1.54e-13 Acne (severe); CRC trans rs4714291 0.862 rs2984433 chr6:39973445 T/G cg02267698 chr19:7991119 CTXN1 -0.48 -6.5 -0.34 2.9e-10 Strep throat; CRC cis rs728616 0.867 rs12414521 chr10:81949534 G/C cg11900509 chr10:81946545 ANXA11 -0.72 -7.26 -0.37 2.88e-12 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs9311676 0.656 rs11712139 chr3:58384775 C/T cg06643156 chr3:58380774 PXK 0.41 6.26 0.33 1.18e-9 Systemic lupus erythematosus; CRC cis rs1577917 0.839 rs12664634 chr6:86579414 A/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.44 -5.81 -0.31 1.48e-8 Response to antipsychotic treatment; CRC cis rs4689592 0.546 rs2359012 chr4:7066053 A/C cg19539972 chr4:7069911 GRPEL1 0.76 9.74 0.47 7.11e-20 Monocyte percentage of white cells; CRC trans rs916888 0.773 rs199445 chr17:44817408 C/T cg13957321 chr17:43675089 NA 0.49 6.15 0.32 2.22e-9 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs1697139 0.604 rs874550 chr5:66530945 C/T cg11553311 chr5:66541588 NA -0.57 -9.83 -0.48 3.73e-20 Breast cancer; CRC cis rs2160860 0.773 rs7839881 chr8:39799228 G/A cg11363097 chr8:39792086 IDO2 -0.42 -7.27 -0.37 2.68e-12 Blood metabolite levels; CRC cis rs9549367 0.713 rs4907593 chr13:113830459 C/T cg24300038 chr13:113819356 PROZ 0.49 6.47 0.34 3.58e-10 Platelet distribution width; CRC cis rs939584 1.000 rs4854344 chr2:638144 G/T cg03610516 chr2:642275 NA 0.42 5.98 0.31 5.93e-9 Body mass index; CRC cis rs2898681 0.519 rs6848200 chr4:53730181 A/G cg00338735 chr4:53728038 RASL11B 0.46 6.17 0.32 1.95e-9 Optic nerve measurement (cup area); CRC trans rs6956675 0.915 rs7787116 chr7:62654060 G/A cg01314568 chr7:57830625 NA -0.62 -8.88 -0.44 4.41e-17 Obesity-related traits; CRC cis rs7586879 0.828 rs1077641 chr2:25123665 G/A cg22495460 chr2:25135724 ADCY3 -0.87 -14.69 -0.63 6.35e-38 Body mass index; CRC cis rs8180040 0.654 rs11714373 chr3:47214817 G/A cg02527881 chr3:46936655 PTH1R 0.33 5.89 0.31 9.44e-9 Colorectal cancer; CRC cis rs1448094 0.511 rs11117023 chr12:86145329 G/A cg02569458 chr12:86230093 RASSF9 -0.48 -8.08 -0.41 1.27e-14 Major depressive disorder; CRC cis rs60871478 1.000 rs4720917 chr7:806998 C/G cg05535760 chr7:792225 HEATR2 0.8 10.66 0.51 5.61e-23 Cerebrospinal P-tau181p levels; CRC cis rs9787249 0.957 rs56064244 chr1:40213890 C/T cg24920358 chr1:40204285 PPIE 0.57 8.56 0.43 4.54e-16 Blood protein levels; CRC cis rs7944584 0.837 rs11039149 chr11:47276675 A/G cg20307385 chr11:47447363 PSMC3 0.76 9.16 0.45 5.84e-18 Fasting blood glucose;Fasting blood glucose (BMI interaction); CRC cis rs7107174 1.000 rs2510039 chr11:77944480 G/A cg02023728 chr11:77925099 USP35 0.54 7.57 0.39 3.81e-13 Testicular germ cell tumor; CRC cis rs2067615 0.524 rs10467029 chr12:107078448 C/T cg15890332 chr12:107067104 RFX4 0.32 5.67 0.3 3.15e-8 Heart rate; CRC cis rs2032447 0.670 rs198834 chr6:26114372 G/A cg03264133 chr6:25882463 NA 0.45 6.19 0.32 1.8e-9 Intelligence (multi-trait analysis); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg22691340 chr12:62997631 C12orf61 0.37 6.13 0.32 2.47e-9 Liver disease severity in Alagille syndrome; CRC cis rs3806843 1.000 rs3756340 chr5:140180451 T/G cg19875535 chr5:140030758 IK 0.63 10.26 0.49 1.26e-21 Depressive symptoms (multi-trait analysis); CRC cis rs9942416 0.660 rs34905687 chr5:74997736 A/G cg00601450 chr5:74908170 NA 0.41 5.94 0.31 7.09e-9 Age-related disease endophenotypes; CRC cis rs853679 0.517 rs2273564 chr6:28057594 A/T cg15786705 chr6:28176104 NA 0.76 9.63 0.47 1.68e-19 Depression; CRC cis rs951366 0.789 rs7536483 chr1:205718858 A/T cg07167872 chr1:205819463 PM20D1 0.76 11.43 0.53 1.01e-25 Menarche (age at onset); CRC cis rs752010 0.811 rs10749836 chr1:42086860 G/C cg06885757 chr1:42089581 HIVEP3 0.36 6.42 0.33 4.84e-10 Lupus nephritis in systemic lupus erythematosus; CRC cis rs6546550 0.867 rs726920 chr2:70152027 G/C cg02498382 chr2:70120550 SNRNP27 -0.56 -9.52 -0.46 3.86e-19 Prevalent atrial fibrillation; CRC cis rs909002 0.800 rs1061770 chr1:32096265 A/G cg13919466 chr1:32135498 COL16A1 -0.31 -5.89 -0.31 9.43e-9 Intelligence (multi-trait analysis); CRC cis rs6662572 0.737 rs72677533 chr1:46536558 T/C cg08644498 chr1:46502608 NA 0.45 7.25 0.37 3.09e-12 Blood protein levels; CRC cis rs2108225 1.000 rs6466190 chr7:107451045 G/T cg18560240 chr7:107437656 SLC26A3 0.56 8.86 0.44 5.09e-17 Ulcerative colitis; CRC cis rs6772849 0.662 rs12494372 chr3:128401693 A/C cg08795948 chr3:128337044 NA 0.35 5.79 0.3 1.63e-8 Monocyte percentage of white cells;Monocyte count; CRC cis rs877282 0.735 rs111609055 chr10:826539 A/G cg17470449 chr10:769945 NA 0.5 7.23 0.37 3.5e-12 Uric acid levels; CRC cis rs1971762 0.523 rs7135101 chr12:54080605 G/A cg06632207 chr12:54070931 ATP5G2 0.4 6.91 0.36 2.6e-11 Height; CRC cis rs860295 0.812 rs6657670 chr1:155787867 C/T cg02153340 chr1:155202674 NA -0.52 -6.21 -0.32 1.57e-9 Body mass index; CRC cis rs208520 0.770 rs1342960 chr6:66883514 T/C cg07460842 chr6:66804631 NA -0.93 -12.55 -0.57 8.48e-30 Exhaled nitric oxide output; CRC cis rs61160187 0.582 rs11740632 chr5:60141245 G/A cg16298547 chr5:60138761 ELOVL7 -0.28 -5.8 -0.3 1.58e-8 Educational attainment (years of education);Educational attainment (college completion); CRC cis rs1348850 0.526 rs2141157 chr2:178374112 C/T cg27490568 chr2:178487706 NA 0.58 7.08 0.36 8.66e-12 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs6460942 0.915 rs7803051 chr7:12306904 A/T cg06484146 chr7:12443880 VWDE -0.56 -7.22 -0.37 3.67e-12 Coronary artery disease; CRC cis rs7584330 0.657 rs10211024 chr2:238353776 A/T cg11271282 chr2:238384023 NA 0.44 5.73 0.3 2.26e-8 Prostate cancer; CRC cis rs3785574 0.962 rs8066463 chr17:61818390 A/G cg11494091 chr17:61959527 GH2 0.37 5.79 0.3 1.64e-8 Height; CRC trans rs7395662 0.963 rs4882002 chr11:48546731 A/C cg21153622 chr11:89784906 NA -0.45 -7.18 -0.37 4.68e-12 HDL cholesterol; CRC trans rs2228479 0.850 rs45524643 chr16:89815824 G/A cg21302420 chr1:112162376 RAP1A 0.72 6.01 0.31 5.05e-9 Skin colour saturation; CRC cis rs6586163 0.872 rs1926197 chr10:90748626 A/G cg03111039 chr10:90751583 FAS;ACTA2 -0.5 -7.21 -0.37 3.77e-12 Chronic lymphocytic leukemia; CRC trans rs56823429 0.634 rs2966097 chr16:81549708 A/G cg26655873 chr3:72818019 SHQ1 0.44 6.05 0.32 3.88e-9 HDL cholesterol; CRC cis rs7781266 0.793 rs2991227 chr7:133283772 A/T cg03336402 chr7:133662267 EXOC4 0.49 5.75 0.3 1.99e-8 Educational attainment (college completion); CRC cis rs763121 0.962 rs5757130 chr22:38937794 G/A cg06022373 chr22:39101656 GTPBP1 0.71 11.25 0.53 4.77e-25 Menopause (age at onset); CRC cis rs7131987 0.683 rs3782511 chr12:29496224 G/A cg09582351 chr12:29534625 ERGIC2 -0.35 -7.35 -0.38 1.6e-12 QT interval; CRC cis rs6564851 0.506 rs72831377 chr16:81257141 A/T cg05274606 chr16:81253692 PKD1L2 -0.35 -5.65 -0.3 3.43e-8 Carotenoid and tocopherol levels; CRC cis rs3741404 0.757 rs2282492 chr11:63918589 A/G cg19465662 chr11:63993652 NUDT22;TRPT1 0.85 13.83 0.61 1.26e-34 Platelet count; CRC cis rs67478160 0.654 rs1535097 chr14:104216649 C/T cg08213375 chr14:104286397 PPP1R13B 0.64 13.6 0.6 9.82e-34 Schizophrenia; CRC cis rs6952808 0.609 rs12699453 chr7:1953056 C/T cg21782813 chr7:2030301 MAD1L1 0.39 7.2 0.37 4e-12 Bipolar disorder and schizophrenia; CRC cis rs7737355 0.673 rs26006 chr5:130982768 A/G cg25547332 chr5:131281432 NA 0.36 5.75 0.3 2.06e-8 Life satisfaction; CRC cis rs4820294 0.646 rs9622675 chr22:38053665 G/T cg21798802 chr22:38057573 PDXP 0.35 5.62 0.3 3.99e-8 Fat distribution (HIV); CRC cis rs28386778 0.799 rs2584612 chr17:61932204 A/G cg25654072 chr17:61904446 PSMC5;FTSJ3 0.69 10.71 0.51 3.81e-23 Prudent dietary pattern; CRC cis rs8177179 0.967 rs4078166 chr3:133435979 C/A cg16262614 chr3:133464971 TF 0.49 9.1 0.45 8.64e-18 Iron status biomarkers (transferrin levels); CRC cis rs6952808 0.723 rs1107592 chr7:2041432 C/T cg14004847 chr7:1930337 MAD1L1 0.41 5.67 0.3 3.2e-8 Bipolar disorder and schizophrenia; CRC cis rs13217239 0.646 rs4583981 chr6:26992023 G/T cg12292205 chr6:26970375 C6orf41 0.56 9.32 0.46 1.78e-18 Schizophrenia; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg10779184 chr7:92462706 CDK6 0.37 6.2 0.32 1.68e-9 Liver disease severity in Alagille syndrome; CRC cis rs72781680 0.644 rs72783627 chr2:24315685 A/C cg20701182 chr2:24300061 SF3B14 0.61 7.18 0.37 4.75e-12 Lymphocyte counts; CRC trans rs2303319 0.504 rs62187613 chr2:162434474 T/C cg14875682 chr5:52083620 ITGA1;PELO -0.75 -6.02 -0.31 4.72e-9 Cognitive function; CRC cis rs9470366 0.848 rs9470361 chr6:36623379 G/A cg08179530 chr6:36648295 CDKN1A 0.48 5.68 0.3 2.98e-8 QRS duration; CRC cis rs2075165 0.870 rs9943105 chr1:156245245 T/C cg20302342 chr1:156215951 PAQR6 0.38 7.23 0.37 3.35e-12 Tonsillectomy; CRC cis rs751728 1.000 rs2296747 chr6:33744882 C/G cg25922239 chr6:33757077 LEMD2 0.62 9.68 0.47 1.13e-19 Crohn's disease; CRC cis rs67340775 0.541 rs200973 chr6:27858421 A/G cg19041857 chr6:27730383 NA -0.61 -6.8 -0.35 4.94e-11 Lung cancer in ever smokers; CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg25220896 chr1:11004296 NA -0.44 -5.99 -0.31 5.43e-9 Diisocyanate-induced asthma; CRC cis rs17376456 0.741 rs10036829 chr5:93309897 G/C cg25358565 chr5:93447407 FAM172A 1.06 10.59 0.5 9.22e-23 Diabetic retinopathy; CRC cis rs425277 0.583 rs1467217 chr1:2045165 G/A cg03732007 chr1:2071316 PRKCZ -0.36 -5.64 -0.3 3.74e-8 Height; CRC cis rs936229 0.749 rs6495127 chr15:75194490 C/T cg10253484 chr15:75165896 SCAMP2 -0.47 -6.97 -0.36 1.79e-11 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); CRC cis rs7811142 0.720 rs7795656 chr7:99950297 A/T cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.61 7.92 0.4 3.66e-14 Platelet count; CRC cis rs1178968 1.000 rs3108462 chr7:72739455 T/C cg25889504 chr7:72793014 NA 0.53 6.04 0.32 4.16e-9 Triglyceride levels; CRC cis rs10504229 0.683 rs11775506 chr8:58133639 G/T cg24829409 chr8:58192753 C8orf71 -0.56 -8.31 -0.42 2.48e-15 Developmental language disorder (linguistic errors); CRC cis rs7524258 0.900 rs7514988 chr1:7271651 C/T cg07173049 chr1:7289937 CAMTA1 0.5 8.62 0.43 2.89e-16 Tourette's syndrome or obsessive-compulsive disorder; CRC cis rs4604732 0.578 rs112449432 chr1:247624180 T/C cg12758973 chr1:247694275 LOC148824;OR2C3 0.43 6.24 0.33 1.32e-9 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CRC cis rs1865760 0.566 rs2051544 chr6:26071093 C/T cg17691542 chr6:26056736 HIST1H1C 0.54 8.18 0.41 6.07e-15 Height; CRC cis rs1018836 0.663 rs2205151 chr8:91483468 A/C cg16814680 chr8:91681699 NA -0.68 -10.11 -0.49 4.06e-21 Ejection fraction in Tripanosoma cruzi seropositivity; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg13284007 chr3:53381865 DCP1A 0.41 6.09 0.32 3.11e-9 Intelligence (multi-trait analysis); CRC cis rs7811142 0.830 rs61735533 chr7:99955866 G/A cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.15 16.85 0.68 2.34e-46 Platelet count; CRC cis rs1401999 1.000 rs939337 chr3:183701147 G/C cg01324343 chr3:183735012 ABCC5 0.81 14.73 0.63 4.66e-38 Anterior chamber depth; CRC cis rs9611565 0.532 rs202627 chr22:41847367 A/T cg06634786 chr22:41940651 POLR3H 0.54 6.65 0.34 1.21e-10 Vitiligo; CRC cis rs1865063 1.000 rs1865063 chr19:11341029 C/T cg00586551 chr19:11347513 LOC55908;DOCK6 0.9 9.17 0.45 5.38e-18 HDL cholesterol levels; CRC cis rs2242194 0.816 rs2242193 chr1:154995503 A/G cg12436631 chr1:155007014 DCST1;DCST2 -0.52 -9.2 -0.45 4.27e-18 Schizophrenia; CRC cis rs4665809 1.000 rs2384321 chr2:26290054 A/G cg25036284 chr2:26402008 FAM59B -0.47 -5.86 -0.31 1.14e-8 Gut microbiome composition (summer); CRC trans rs61931739 0.534 rs11052991 chr12:34059018 G/T cg26384229 chr12:38710491 ALG10B -0.51 -6.96 -0.36 1.87e-11 Morning vs. evening chronotype; CRC cis rs1568889 0.838 rs6484359 chr11:28262328 A/T cg06544937 chr11:28130018 METT5D1;KIF18A 0.9 15.0 0.64 4.16e-39 Bipolar disorder; CRC cis rs10540 1.000 rs61877760 chr11:506596 C/T cg19913688 chr11:428466 ANO9 -0.69 -7.09 -0.36 8.4e-12 Body mass index; CRC cis rs654950 0.783 rs668359 chr1:42003425 A/C cg06885757 chr1:42089581 HIVEP3 -0.4 -6.63 -0.34 1.38e-10 Airway imaging phenotypes; CRC cis rs7762018 0.607 rs77972667 chr6:170130456 G/C cg24289452 chr6:170231220 NA -0.99 -8.06 -0.41 1.46e-14 Thiazide-induced adverse metabolic effects in hypertensive patients; CRC trans rs6550704 0.687 rs9865314 chr3:22634337 A/G cg10542027 chr5:78532229 JMY -0.41 -6.38 -0.33 6.12e-10 Daytime sleep phenotypes; CRC trans rs60843830 1.000 rs60149603 chr2:285421 A/G cg11347411 chr7:150020925 ACTR3C;LRRC61 0.63 9.79 0.47 4.91e-20 Spherical equivalent (joint analysis main effects and education interaction); CRC cis rs875971 0.862 rs6955837 chr7:66043142 C/T cg18876405 chr7:65276391 NA -0.53 -8.55 -0.43 4.8e-16 Aortic root size; CRC trans rs800082 0.839 rs11714177 chr3:144312862 T/C cg24215973 chr2:240111563 HDAC4 -0.54 -6.89 -0.36 2.83e-11 Smoking behavior; CRC cis rs7312774 0.618 rs11612483 chr12:107346884 A/G cg16260113 chr12:107380972 MTERFD3 0.79 8.09 0.41 1.18e-14 Severe influenza A (H1N1) infection; CRC cis rs2019137 0.560 rs4849179 chr2:113985170 C/T cg21610815 chr2:113994035 PAX8;LOC654433;LOC440839 0.57 8.53 0.43 5.46e-16 Lymphocyte counts; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg20659025 chr11:126173961 DCPS 0.39 6.16 0.32 2.12e-9 Liver disease severity in Alagille syndrome; CRC cis rs7703744 0.634 rs112352373 chr5:118687625 C/G cg23985447 chr5:118691066 TNFAIP8 0.4 5.63 0.3 3.87e-8 Lobe attachment (rater-scored or self-reported); CRC cis rs17234274 0.644 rs10833966 chr11:23214937 C/G cg05245346 chr11:23248277 NA 0.37 6.1 0.32 3.04e-9 Cancer; CRC cis rs4588572 0.643 rs1560197 chr5:77768302 T/C cg11446398 chr5:77624930 NA 0.46 6.27 0.33 1.14e-9 Triglycerides; CRC cis rs35883536 0.647 rs59667512 chr1:101046712 C/T cg06223162 chr1:101003688 GPR88 -0.34 -6.11 -0.32 2.86e-9 Monocyte count; CRC cis rs7618915 0.547 rs13069481 chr3:52666866 C/T cg10802521 chr3:52805072 NEK4 -0.58 -8.96 -0.44 2.53e-17 Bipolar disorder; CRC trans rs12699921 0.598 rs2723505 chr7:17854849 C/T cg02066331 chr6:17282778 RBM24 -0.35 -6.1 -0.32 2.9e-9 Fibrinogen levels; CRC cis rs9858542 0.953 rs6766581 chr3:49539401 T/C cg03060546 chr3:49711283 APEH -0.47 -6.56 -0.34 2.08e-10 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs2836950 0.545 rs4818001 chr21:40575088 T/C cg17971929 chr21:40555470 PSMG1 -0.59 -8.55 -0.43 4.74e-16 Menarche (age at onset); CRC cis rs2404602 0.647 rs11072619 chr15:77043242 A/C cg23625390 chr15:77176239 SCAPER -0.87 -14.46 -0.62 5.11e-37 Blood metabolite levels; CRC cis rs10503871 0.690 rs7840384 chr8:30349914 A/G cg26383811 chr8:30366931 RBPMS 0.49 7.79 0.39 8.93e-14 Metabolite levels (X-11787); CRC cis rs2404602 1.000 rs2404602 chr15:77030792 A/G cg22467129 chr15:76604101 ETFA -0.38 -6.38 -0.33 5.85e-10 Blood metabolite levels; CRC cis rs910316 1.000 rs10138183 chr14:75615227 T/C cg03030879 chr14:75389066 RPS6KL1 -0.46 -7.16 -0.37 5.45e-12 Height; CRC cis rs290268 0.838 rs1333635 chr9:93566406 A/G cg02608019 chr9:93564028 SYK 0.46 7.18 0.37 4.55e-12 Platelet count; CRC cis rs2952156 0.883 rs907088 chr17:37833567 G/C cg11212589 chr17:38028394 ZPBP2 0.35 6.15 0.32 2.26e-9 Asthma; CRC cis rs2115630 0.936 rs11073663 chr15:85260268 A/G cg12501888 chr15:85177176 SCAND2 -0.37 -5.93 -0.31 7.57e-9 P wave terminal force; CRC cis rs7923609 1.000 rs7923609 chr10:65133822 A/G cg08743896 chr10:65200160 JMJD1C -0.4 -5.76 -0.3 1.98e-8 Educational attainment;Liver enzyme levels (alkaline phosphatase); CRC cis rs367615 0.660 rs10061221 chr5:108839038 C/T cg17395555 chr5:108820864 NA 0.46 9.38 0.46 1.08e-18 Colorectal cancer (SNP x SNP interaction); CRC cis rs66782572 1 rs66782572 chr3:52567617 A/G cg05573699 chr3:52720067 GNL3;PBRM1 -0.43 -6.66 -0.34 1.17e-10 Hemoglobin concentration; CRC cis rs6582630 0.576 rs4882375 chr12:38371939 G/T cg13010199 chr12:38710504 ALG10B -0.4 -5.69 -0.3 2.87e-8 Drug-induced liver injury (flucloxacillin); CRC cis rs2991971 0.967 rs11211130 chr1:45986852 G/C cg24296786 chr1:45957014 TESK2 0.58 8.7 0.43 1.58e-16 High light scatter reticulocyte count; CRC cis rs853679 0.760 rs11967137 chr6:28199764 A/G cg21251018 chr6:28226885 NKAPL 0.51 5.98 0.31 5.84e-9 Depression; CRC cis rs637571 0.512 rs660118 chr11:65735174 G/C cg02427764 chr11:65769310 BANF1;EIF1AD 0.41 5.63 0.3 3.93e-8 Eosinophil percentage of white cells; CRC cis rs2032447 0.832 rs10425 chr6:26056549 A/G cg27635394 chr6:26043820 HIST1H2BB 0.4 5.97 0.31 6.09e-9 Intelligence (multi-trait analysis); CRC trans rs11148252 0.740 rs9596643 chr13:52912380 G/A cg18335740 chr13:41363409 SLC25A15 -0.52 -7.73 -0.39 1.34e-13 Lewy body disease; CRC cis rs936229 0.749 rs4886633 chr15:75178207 G/A cg14664628 chr15:75095509 CSK -0.86 -14.51 -0.62 3.15e-37 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); CRC cis rs972578 1.000 rs738389 chr22:43332516 T/C cg01576275 chr22:43409880 NA -0.44 -7.09 -0.36 8.01e-12 Mean platelet volume; CRC cis rs72945132 1.000 rs72945132 chr11:70113901 G/C cg14191688 chr11:70257035 CTTN 0.52 6.49 0.34 3.11e-10 Coronary artery disease; CRC cis rs2404602 0.672 rs35374222 chr15:77071394 G/T cg23625390 chr15:77176239 SCAPER -0.85 -13.11 -0.59 7.08e-32 Blood metabolite levels; CRC cis rs875971 0.545 rs75577046 chr7:65958716 A/G cg05627663 chr7:65219948 SNORA22;CCT6P1 0.59 7.52 0.38 5.26e-13 Aortic root size; CRC cis rs7824557 0.527 rs57629785 chr8:11235150 C/A cg20542592 chr8:11973495 FAM66D 0.32 5.69 0.3 2.81e-8 Retinal vascular caliber; CRC cis rs6540559 1.000 rs1044516 chr1:209959614 G/T cg25204440 chr1:209979598 IRF6 0.5 6.58 0.34 1.9e-10 Cleft lip with or without cleft palate; CRC cis rs7493 0.755 rs116306774 chr7:95016976 G/A cg04155289 chr7:94953770 PON1 -0.59 -7.29 -0.37 2.26e-12 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs2456568 0.778 rs7944194 chr11:93682413 C/G cg26875233 chr11:93583750 C11orf90 0.31 5.9 0.31 9.1e-9 Response to serotonin reuptake inhibitors in major depressive disorder; CRC cis rs56114371 0.530 rs9348774 chr6:27688930 C/T cg19041857 chr6:27730383 NA -0.46 -6.03 -0.32 4.35e-9 Breast cancer; CRC cis rs60871478 1.000 rs67721251 chr7:825114 T/C cg13844804 chr7:814759 HEATR2 0.61 8.04 0.41 1.61e-14 Cerebrospinal P-tau181p levels; CRC cis rs2732480 0.967 rs2732469 chr12:48712932 T/A cg21466736 chr12:48725269 NA -0.48 -7.41 -0.38 1.06e-12 Hemoglobin concentration;Red blood cell count;Hematocrit; CRC cis rs7429990 0.965 rs4858810 chr3:48043737 G/A cg11946769 chr3:48343235 NME6 -0.5 -6.34 -0.33 7.42e-10 Educational attainment (years of education); CRC cis rs76878669 0.538 rs1546358 chr11:66175261 G/C cg18002602 chr11:66138449 SLC29A2 0.29 6.03 0.32 4.49e-9 Educational attainment (years of education); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg10744248 chr7:76009385 NA 0.43 6.04 0.32 4.12e-9 Response to antipsychotic treatment; CRC cis rs11212617 0.967 rs4753833 chr11:108057430 G/A cg12106634 chr11:108092400 ATM;NPAT 0.39 5.7 0.3 2.71e-8 Response to metformin in type 2 diabetes (glycemic); CRC cis rs11711311 1.000 rs13070720 chr3:113473754 C/T cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.51 -6.92 -0.36 2.31e-11 IgG glycosylation; CRC cis rs801193 0.591 rs721717 chr7:66130292 G/T cg18252515 chr7:66147081 NA 0.44 6.2 0.32 1.72e-9 Aortic root size; CRC cis rs853679 0.517 rs9368551 chr6:28061792 A/G cg12172441 chr6:28176163 NA 0.62 7.38 0.38 1.28e-12 Depression; CRC cis rs4722166 0.695 rs7808122 chr7:22798080 A/G cg26061582 chr7:22766209 IL6 0.5 8.0 0.4 2.17e-14 Lung cancer; CRC cis rs7772486 0.790 rs2265917 chr6:146212285 A/G cg23711669 chr6:146136114 FBXO30 0.71 12.57 0.57 7.11e-30 Lobe attachment (rater-scored or self-reported); CRC cis rs11098499 0.779 rs10011097 chr4:120310359 T/G cg09307838 chr4:120376055 NA 0.7 10.82 0.51 1.47e-23 Corneal astigmatism; CRC cis rs1707322 0.686 rs1541131 chr1:46084934 G/A cg06784218 chr1:46089804 CCDC17 -0.65 -11.68 -0.54 1.32e-26 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs9311474 0.629 rs13081028 chr3:52555316 G/A cg08365687 chr3:52569147 NT5DC2;LOC440957 0.35 5.74 0.3 2.18e-8 Electroencephalogram traits; CRC cis rs875971 0.545 rs2173571 chr7:65770379 G/A cg11764359 chr7:65958608 NA 0.46 5.77 0.3 1.83e-8 Aortic root size; CRC cis rs4481887 0.854 rs4534423 chr1:248474993 G/C cg13385794 chr1:248469461 NA 0.37 6.58 0.34 1.88e-10 Common traits (Other); CRC trans rs1728785 0.901 rs2862781 chr16:68639234 A/T cg04657470 chr2:198365150 HSPE1;HSPD1 0.6 7.27 0.37 2.64e-12 Ulcerative colitis; CRC cis rs10540 0.570 rs8176330 chr11:535798 G/A cg15790184 chr11:494944 RNH1 0.57 5.71 0.3 2.59e-8 Body mass index; CRC cis rs12476592 0.602 rs171901 chr2:63901700 C/G cg10828910 chr2:63850056 LOC388955 -0.5 -6.29 -0.33 1.02e-9 Childhood ear infection; CRC cis rs9467711 0.591 rs13195279 chr6:25919431 T/A cg16898833 chr6:26189333 HIST1H4D 0.76 6.57 0.34 2e-10 Autism spectrum disorder or schizophrenia; CRC cis rs4654899 1.000 rs10916921 chr1:21334542 C/T cg02927042 chr1:21476669 EIF4G3 -0.48 -7.76 -0.39 1.09e-13 Superior frontal gyrus grey matter volume; CRC cis rs853679 0.546 rs34295134 chr6:27828151 T/A cg03623178 chr6:28175578 NA 0.77 6.69 0.35 9.81e-11 Depression; CRC cis rs8180040 0.835 rs6780013 chr3:47452118 G/A cg02527881 chr3:46936655 PTH1R 0.36 6.37 0.33 6.24e-10 Colorectal cancer; CRC cis rs9322193 0.923 rs12205092 chr6:150082511 G/T cg05861140 chr6:150128134 PCMT1 -0.4 -6.26 -0.33 1.2e-9 Lung cancer; CRC cis rs1129187 0.902 rs6907751 chr6:42944850 C/T cg05552183 chr6:42928497 GNMT 0.68 11.35 0.53 1.98e-25 Alzheimer's disease in APOE e4+ carriers; CRC cis rs9583531 0.600 rs9555724 chr13:111354110 C/T cg24331049 chr13:111365604 ING1 -0.55 -7.79 -0.39 8.78e-14 Coronary artery disease; CRC cis rs13108904 0.870 rs13115355 chr4:1261576 G/A cg21620606 chr4:1342894 KIAA1530 0.38 6.45 0.33 4.07e-10 Obesity-related traits; CRC cis rs10489202 0.608 rs16828093 chr1:168078384 C/T cg24449463 chr1:168025552 DCAF6 -0.52 -7.45 -0.38 8.18e-13 Schizophrenia; CRC cis rs8180040 0.966 rs3736177 chr3:47451411 C/T cg10298567 chr3:47292165 KIF9 0.39 6.13 0.32 2.46e-9 Colorectal cancer; CRC cis rs11711311 1.000 rs9827682 chr3:113450251 A/G cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.51 -7.02 -0.36 1.31e-11 IgG glycosylation; CRC cis rs611744 0.631 rs681963 chr8:109255032 C/A cg18478394 chr8:109455254 TTC35 0.37 5.78 0.3 1.75e-8 Dupuytren's disease; CRC cis rs11148252 0.634 rs1571189 chr13:52731004 A/T cg00495681 chr13:53174319 NA 0.54 7.88 0.4 4.93e-14 Lewy body disease; CRC cis rs9549367 0.713 rs3024745 chr13:113821598 A/G cg00898013 chr13:113819073 PROZ -0.59 -8.5 -0.42 6.54e-16 Platelet distribution width; CRC cis rs34779708 0.931 rs10508815 chr10:35332621 A/C cg03585969 chr10:35415529 CREM 0.6 8.14 0.41 8.07e-15 Inflammatory bowel disease;Crohn's disease; CRC cis rs2404602 0.647 rs11072631 chr15:77132909 T/C cg03037974 chr15:76606532 NA -0.52 -7.31 -0.37 2.04e-12 Blood metabolite levels; CRC cis rs910316 0.737 rs175049 chr14:75481368 C/T cg08847533 chr14:75593920 NEK9 -0.84 -14.65 -0.63 9.16e-38 Height; CRC trans rs6479874 0.681 rs9415727 chr10:52886136 G/T cg20384632 chr7:106508080 PIK3CG -0.47 -5.96 -0.31 6.48e-9 Migraine; CRC cis rs262150 0.704 rs2730236 chr7:158765543 C/T cg04239562 chr7:158767014 NA 0.36 5.66 0.3 3.23e-8 Facial morphology (factor 20); CRC cis rs7584330 0.780 rs7582828 chr2:238378476 A/C cg14458575 chr2:238380390 NA -0.65 -12.16 -0.56 2.29e-28 Prostate cancer; CRC cis rs2479724 0.846 rs2488338 chr6:41808351 A/G cg17623882 chr6:41773611 USP49 -0.53 -8.86 -0.44 4.96e-17 Menarche (age at onset); CRC cis rs4728302 0.869 rs6966403 chr7:133614421 A/C cg03336402 chr7:133662267 EXOC4 0.41 5.94 0.31 7.18e-9 Intelligence;Intelligence (multi-trait analysis); CRC cis rs12594515 1.000 rs8039622 chr15:45986431 A/G cg01629716 chr15:45996671 NA 0.41 8.42 0.42 1.19e-15 Waist circumference;Weight; CRC cis rs1707322 0.752 rs12047629 chr1:46162802 G/A cg06784218 chr1:46089804 CCDC17 0.65 12.15 0.56 2.54e-28 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs2932538 0.922 rs7527076 chr1:113150481 G/A cg22162597 chr1:113214053 CAPZA1 0.72 10.31 0.49 8.65e-22 Systolic blood pressure;Diastolic blood pressure;Hypertension;Blood pressure; CRC cis rs4713118 0.869 rs9295742 chr6:27702832 G/A cg15786705 chr6:28176104 NA 0.54 7.62 0.39 2.72e-13 Parkinson's disease; CRC cis rs7493 1.000 rs2158806 chr7:95051998 A/C cg07404485 chr7:94953653 PON1 -0.47 -6.14 -0.32 2.43e-9 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs172166 0.637 rs1225597 chr6:28162087 C/T cg26587870 chr6:27730563 NA -0.36 -5.62 -0.3 4.14e-8 Cardiac Troponin-T levels; CRC cis rs7584330 0.868 rs58057291 chr2:238395479 T/A cg16989719 chr2:238392110 NA -0.47 -8.5 -0.42 6.64e-16 Prostate cancer; CRC cis rs28386778 0.897 rs6504177 chr17:61812655 C/T cg06873352 chr17:61820015 STRADA 0.74 13.96 0.61 4.23e-35 Prudent dietary pattern; CRC cis rs6951245 0.935 rs79067319 chr7:1065548 C/T cg04025307 chr7:1156635 C7orf50 0.64 6.83 0.35 4.11e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs6963495 0.818 rs56268110 chr7:105166712 T/C cg13798780 chr7:105162888 PUS7 0.69 8.2 0.41 5.36e-15 Bipolar disorder (body mass index interaction); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg07404363 chr5:112197029 SRP19 0.39 6.15 0.32 2.2e-9 Liver disease severity in Alagille syndrome; CRC cis rs9491140 0.539 rs11755888 chr6:124693042 A/G cg05308643 chr6:124982296 NKAIN2 0.51 6.83 0.35 4.05e-11 Neuroticism; CRC cis rs10944 0.598 rs688286 chr5:78276665 G/A cg13121490 chr5:78280331 ARSB -0.44 -6.31 -0.33 9.23e-10 Blood and toenail selenium levels; CRC cis rs1577917 1.000 rs1857964 chr6:86635994 A/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.53 -6.61 -0.34 1.53e-10 Response to antipsychotic treatment; CRC cis rs1129187 0.967 rs3805952 chr6:42937126 C/T cg10862848 chr6:42927986 GNMT -0.38 -8.93 -0.44 3.17e-17 Alzheimer's disease in APOE e4+ carriers; CRC cis rs4803468 1.000 rs2241711 chr19:41911980 T/C cg09537434 chr19:41945824 ATP5SL -0.98 -18.86 -0.72 2.59e-54 Height; CRC cis rs4713118 0.824 rs9468225 chr6:27745719 T/G cg21251018 chr6:28226885 NKAPL 0.42 5.96 0.31 6.51e-9 Parkinson's disease; CRC cis rs9322193 0.884 rs10782312 chr6:149943805 G/T cg07701084 chr6:150067640 NUP43 0.55 8.04 0.41 1.58e-14 Lung cancer; CRC cis rs7586879 0.598 rs6724772 chr2:25128730 T/C cg22495460 chr2:25135724 ADCY3 -0.87 -17.39 -0.69 1.75e-48 Body mass index; CRC cis rs7618501 0.699 rs2681781 chr3:49898273 A/G cg24308560 chr3:49941425 MST1R -0.49 -7.65 -0.39 2.21e-13 Intelligence (multi-trait analysis); CRC cis rs7647973 0.580 rs35218722 chr3:49275805 A/G cg03060546 chr3:49711283 APEH 0.48 7.08 0.36 8.6e-12 Menarche (age at onset); CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg26335527 chr1:155100185 EFNA1 0.45 6.2 0.32 1.65e-9 Anxiety disorder; CRC trans rs6066835 0.572 rs6125413 chr20:47257145 G/A cg21109867 chr19:55897418 RPL28 -0.84 -6.29 -0.33 1.01e-9 Multiple myeloma; CRC cis rs10791323 0.593 rs11223599 chr11:133717902 A/T cg00579200 chr11:133705235 NA 0.42 6.18 0.32 1.93e-9 Childhood ear infection; CRC cis rs561341 1.000 rs55736640 chr17:30333848 G/A cg19193384 chr17:30244184 NA -0.66 -7.6 -0.39 3.18e-13 Hip circumference adjusted for BMI; CRC cis rs28386778 0.830 rs2665841 chr17:61861219 A/T cg11494091 chr17:61959527 GH2 0.62 10.57 0.5 1.11e-22 Prudent dietary pattern; CRC cis rs9325144 0.650 rs6582624 chr12:38733475 A/T cg26384229 chr12:38710491 ALG10B -0.57 -8.12 -0.41 9.45e-15 Morning vs. evening chronotype; CRC cis rs57994353 0.861 rs13301660 chr9:139340802 C/T cg14119001 chr9:139324193 INPP5E -0.45 -6.39 -0.33 5.69e-10 Eosinophil counts;Cutaneous squamous cell carcinoma; CRC cis rs73200209 0.912 rs10507268 chr12:116540227 G/A cg01776926 chr12:116560359 MED13L -0.51 -6.27 -0.33 1.11e-9 Total body bone mineral density; CRC cis rs2204008 0.775 rs12369238 chr12:38176051 A/G cg13010199 chr12:38710504 ALG10B 0.45 5.96 0.31 6.55e-9 Bladder cancer; CRC trans rs10155879 0.505 rs12704265 chr7:86142678 A/G cg22710661 chr11:17411071 KCNJ11 0.54 6.06 0.32 3.7e-9 Interleukin-4 levels; CRC cis rs6764363 0.587 rs459980 chr3:285569 A/G cg02057681 chr3:285234 CHL1 -0.44 -7.59 -0.39 3.29e-13 Sudden cardiac arrest; CRC cis rs4728302 0.869 rs2042456 chr7:133580447 G/A cg03336402 chr7:133662267 EXOC4 -0.43 -6.15 -0.32 2.23e-9 Intelligence;Intelligence (multi-trait analysis); CRC cis rs7246657 0.943 rs7255407 chr19:37933936 G/A cg23950597 chr19:37808831 NA -0.49 -6.05 -0.32 3.93e-9 Coronary artery calcification; CRC cis rs6694672 1.000 rs2026429 chr1:197079671 A/C cg13682187 chr1:196946512 CFHR5 -0.46 -7.74 -0.39 1.25e-13 Asthma; CRC cis rs9807989 0.839 rs13392100 chr2:102982094 C/A cg03938978 chr2:103052716 IL18RAP 0.37 6.02 0.31 4.69e-9 Asthma; CRC cis rs4862750 0.914 rs9998558 chr4:187874691 A/G cg03647317 chr4:187891568 NA -0.53 -9.92 -0.48 1.77e-20 Lobe attachment (rater-scored or self-reported); CRC cis rs4713118 0.662 rs469228 chr6:27970704 A/G cg21251018 chr6:28226885 NKAPL 0.45 6.89 0.36 2.83e-11 Parkinson's disease; CRC cis rs10479542 0.544 rs7706275 chr5:178990305 A/G cg22764044 chr5:178986830 RUFY1 0.4 6.1 0.32 2.96e-9 Lung cancer; CRC cis rs2380220 1.000 rs2380220 chr6:95967412 T/C cg04719120 chr6:96025338 MANEA 0.59 6.72 0.35 8.02e-11 Behavioural disinhibition (generation interaction); CRC cis rs4481887 1.000 rs10888356 chr1:248465044 C/T cg00666640 chr1:248458726 OR2T12 -0.52 -9.33 -0.46 1.59e-18 Common traits (Other); CRC cis rs6062302 0.522 rs3787107 chr20:62230576 G/A cg06363034 chr20:62225388 GMEB2 -0.45 -6.88 -0.35 2.94e-11 Glioblastoma; CRC cis rs2380220 0.720 rs9374178 chr6:95979974 G/T cg15832292 chr6:96025679 MANEA 0.61 6.63 0.34 1.41e-10 Behavioural disinhibition (generation interaction); CRC cis rs10905065 0.610 rs4748307 chr10:5747701 C/T cg11519256 chr10:5708881 ASB13 -0.44 -6.04 -0.32 4.21e-9 Menopause (age at onset); CRC cis rs3736485 0.868 rs4774597 chr15:51919656 T/C cg08986416 chr15:51914746 DMXL2 -0.45 -6.38 -0.33 6.11e-10 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs5750830 0.594 rs6001587 chr22:39819008 T/C cg25459000 chr22:39777742 SYNGR1 -0.34 -6.05 -0.32 3.91e-9 Intelligence (multi-trait analysis); CRC cis rs9818758 0.607 rs12185979 chr3:49651970 C/G cg01304814 chr3:48885189 PRKAR2A 0.9 6.38 0.33 6.15e-10 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; CRC cis rs853679 0.517 rs67878650 chr6:28142587 G/C cg03623178 chr6:28175578 NA 0.97 12.38 0.56 3.55e-29 Depression; CRC cis rs7428 0.527 rs7607284 chr2:85547376 C/G cg24342717 chr2:85555507 TGOLN2 -0.78 -12.69 -0.57 2.61e-30 Ear protrusion; CRC cis rs10504229 0.683 rs903706 chr8:58128134 T/G cg21724239 chr8:58056113 NA 0.49 6.81 0.35 4.75e-11 Developmental language disorder (linguistic errors); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg14193886 chr22:30642728 LIF 0.45 6.55 0.34 2.19e-10 Response to antipsychotic treatment; CRC cis rs7712401 0.791 rs6872932 chr5:122145636 A/G cg18764291 chr5:122110994 SNX2 0.39 6.11 0.32 2.74e-9 Mean platelet volume; CRC cis rs1552244 0.882 rs55808392 chr3:10054681 C/T cg00166722 chr3:10149974 C3orf24 0.61 7.88 0.4 4.95e-14 Alzheimer's disease; CRC cis rs72945132 0.882 rs947812 chr11:70209169 C/T cg00319359 chr11:70116639 PPFIA1 0.65 6.7 0.35 8.92e-11 Coronary artery disease; CRC trans rs10504229 0.953 rs75253516 chr8:58171547 C/A cg04077850 chr5:125800366 GRAMD3 0.38 6.2 0.32 1.73e-9 Developmental language disorder (linguistic errors); CRC trans rs1864585 0.520 rs73208785 chr8:10678120 T/C cg26278703 chr11:58910052 FAM111A 0.55 6.39 0.33 5.72e-10 Neutrophil percentage of white cells;Lymphocyte percentage of white cells; CRC cis rs231513 0.911 rs124719 chr17:41960343 T/C cg26893861 chr17:41843967 DUSP3 -0.65 -6.53 -0.34 2.46e-10 Cognitive function; CRC cis rs6502050 0.799 rs12940433 chr17:80120826 C/T cg25804541 chr17:80189381 SLC16A3 -0.31 -5.95 -0.31 6.84e-9 Life satisfaction; CRC cis rs875971 0.545 rs73142265 chr7:65699497 G/A cg18876405 chr7:65276391 NA 0.46 6.26 0.33 1.21e-9 Aortic root size; CRC cis rs6547741 0.816 rs7560847 chr2:27882700 A/G cg22903471 chr2:27725779 GCKR -0.34 -5.64 -0.3 3.62e-8 Oral cavity cancer; CRC cis rs2070677 1.000 rs1410897 chr10:135349537 G/A cg16964102 chr10:135390573 NA -0.49 -6.88 -0.35 3.09e-11 Gout; CRC cis rs9486719 1.000 rs11152969 chr6:96908712 A/C cg18709589 chr6:96969512 KIAA0776 -0.5 -5.69 -0.3 2.87e-8 Migraine;Coronary artery disease; CRC cis rs7216064 1.000 rs62084248 chr17:65874541 C/T cg12091567 chr17:66097778 LOC651250 -0.67 -7.74 -0.39 1.24e-13 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CRC cis rs1113500 0.862 rs2336129 chr1:108640669 A/G cg06207961 chr1:108661230 NA -0.38 -5.64 -0.3 3.67e-8 Growth-regulated protein alpha levels; CRC cis rs34172651 0.517 rs34172679 chr16:24840381 C/T cg06505273 chr16:24850292 NA 0.53 6.53 0.34 2.48e-10 Intelligence (multi-trait analysis); CRC cis rs10504229 0.683 rs7463453 chr8:58112053 A/G cg02725872 chr8:58115012 NA -0.66 -11.64 -0.54 1.83e-26 Developmental language disorder (linguistic errors); CRC cis rs7618501 0.633 rs12496973 chr3:50002245 T/C cg24308560 chr3:49941425 MST1R -0.53 -9.0 -0.44 1.8e-17 Intelligence (multi-trait analysis); CRC cis rs8177253 0.898 rs8177258 chr3:133480387 C/A cg11941060 chr3:133502564 NA -0.58 -10.13 -0.49 3.47e-21 Iron status biomarkers; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg00562905 chr17:42634144 FZD2 0.47 6.6 0.34 1.63e-10 Response to antipsychotic treatment; CRC cis rs4664293 0.967 rs7597482 chr2:160547091 T/A cg08347373 chr2:160653686 CD302 -0.38 -6.18 -0.32 1.9e-9 Monocyte percentage of white cells; CRC cis rs9287719 0.935 rs1309 chr2:10743546 A/G cg00105475 chr2:10696890 NA 0.45 7.3 0.37 2.19e-12 Prostate cancer; CRC cis rs1552172 0.853 rs4970859 chr1:145605318 A/G cg11743829 chr1:145714124 CD160 0.41 6.25 0.33 1.26e-9 Breast cancer; CRC trans rs7618501 0.602 rs2071206 chr3:50160109 G/A cg21659725 chr3:3221576 CRBN -0.55 -8.71 -0.43 1.52e-16 Intelligence (multi-trait analysis); CRC cis rs10746514 0.833 rs11122428 chr1:232261417 A/G cg09506761 chr1:232265262 NA -0.47 -6.79 -0.35 5.33e-11 Response to statin therapy; CRC cis rs12630931 0.929 rs11708350 chr3:31983244 A/G cg21375017 chr3:31988082 OSBPL10 0.43 5.79 0.3 1.6e-8 Periodontal disease-related phenotypes; CRC cis rs6502050 0.835 rs4459614 chr17:80086597 C/T cg25804541 chr17:80189381 SLC16A3 0.32 6.11 0.32 2.89e-9 Life satisfaction; CRC trans rs6902257 0.744 rs2496683 chr6:81329501 T/C cg16210497 chr6:85474188 TBX18 0.6 6.05 0.32 3.89e-9 Obesity-related traits; CRC cis rs67311347 1.000 rs4973993 chr3:40452960 T/C cg09455208 chr3:40491958 NA 0.48 9.21 0.45 3.8e-18 Renal cell carcinoma; CRC cis rs1670533 1.000 rs6850784 chr4:1059809 G/A cg27284194 chr4:1044797 NA 0.5 6.23 0.32 1.46e-9 Recombination rate (females); CRC cis rs10504229 0.906 rs7842855 chr8:58167718 G/C cg02725872 chr8:58115012 NA -0.45 -8.62 -0.43 2.91e-16 Developmental language disorder (linguistic errors); CRC cis rs7605378 0.528 rs812760 chr2:200724372 C/T cg23649088 chr2:200775458 C2orf69 0.69 11.26 0.53 4.28e-25 Osteoporosis; CRC cis rs6952808 0.564 rs55865401 chr7:2145720 G/C cg22963979 chr7:1858916 MAD1L1 -0.46 -6.71 -0.35 8.48e-11 Bipolar disorder and schizophrenia; CRC cis rs3126085 0.935 rs4845745 chr1:152185184 C/T cg09127314 chr1:152161683 NA 0.51 6.52 0.34 2.66e-10 Atopic dermatitis; CRC cis rs9826463 0.582 rs73238152 chr3:142071081 C/T cg20824294 chr3:142316082 PLS1 0.36 5.73 0.3 2.32e-8 QRS duration in Tripanosoma cruzi seropositivity; CRC cis rs35849525 0.633 rs62263602 chr3:50152491 C/T cg24110177 chr3:50126178 RBM5 -0.49 -5.64 -0.3 3.76e-8 Intelligence (multi-trait analysis); CRC cis rs7811142 0.830 rs61735533 chr7:99955866 G/A cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.73 9.99 0.48 1.07e-20 Platelet count; CRC cis rs4713118 0.738 rs200465 chr6:27757654 T/A cg02683197 chr6:28174875 NA 0.66 8.65 0.43 2.3e-16 Parkinson's disease; CRC cis rs6424115 0.767 rs11591202 chr1:24102080 A/C cg08896387 chr1:24191740 FUCA1 0.51 6.75 0.35 6.58e-11 Immature fraction of reticulocytes; CRC trans rs1814175 0.519 rs10839291 chr11:49514321 G/A cg03929089 chr4:120376271 NA 0.76 10.13 0.49 3.67e-21 Height; CRC cis rs7618501 0.521 rs2883059 chr3:49902160 C/T cg05623727 chr3:50126028 RBM5 -0.58 -9.79 -0.47 5.12e-20 Intelligence (multi-trait analysis); CRC cis rs898097 0.841 rs2271918 chr17:80861206 A/G cg15369054 chr17:80825471 TBCD 0.52 8.07 0.41 1.37e-14 Breast cancer; CRC cis rs920590 0.758 rs1826420 chr8:19664878 G/T cg03894339 chr8:19674705 INTS10 0.42 5.84 0.31 1.28e-8 Acute lymphoblastic leukemia (childhood); CRC cis rs10751667 0.666 rs10794347 chr11:939863 G/A ch.11.42038R chr11:967971 AP2A2 0.58 9.85 0.48 3.1e-20 Alzheimer's disease (late onset); CRC cis rs9660180 0.846 rs10907195 chr1:1713348 C/T cg23982607 chr1:1823379 GNB1 0.64 10.06 0.49 6.01e-21 Body mass index; CRC cis rs4716602 0.596 rs10258969 chr7:156157753 A/G cg16983916 chr7:156159713 NA -0.39 -6.92 -0.36 2.36e-11 Anti-saccade response; CRC cis rs7617773 0.778 rs11715776 chr3:48377611 G/C cg11946769 chr3:48343235 NME6 0.74 9.91 0.48 2.03e-20 Coronary artery disease; CRC cis rs1215050 0.818 rs6532703 chr4:98777486 A/T cg05340658 chr4:99064831 C4orf37 0.44 6.11 0.32 2.75e-9 Waist-to-hip ratio adjusted for body mass index; CRC cis rs12760731 0.623 rs6701584 chr1:178290509 C/T cg00404053 chr1:178313656 RASAL2 0.7 8.89 0.44 4.09e-17 Obesity-related traits; CRC cis rs9534288 0.762 rs1571052 chr13:46554849 A/G cg15192986 chr13:46630673 CPB2 -0.67 -9.86 -0.48 2.81e-20 Blood protein levels; CRC cis rs67311347 1.000 rs7636719 chr3:40432084 C/T cg24209194 chr3:40518798 ZNF619 0.42 6.42 0.33 4.82e-10 Renal cell carcinoma; CRC trans rs951252 0.504 rs11734405 chr4:146081096 C/T cg03871162 chr6:17611359 FAM8A1 0.31 6.11 0.32 2.85e-9 Hip circumference; CRC trans rs561341 1.000 rs576985 chr17:30323323 C/T cg20587970 chr11:113659929 NA -1.43 -20.38 -0.75 2.82e-60 Hip circumference adjusted for BMI; CRC cis rs2721195 1.000 rs6599530 chr8:145677418 C/G cg26752003 chr8:145688521 CYHR1 0.57 9.82 0.48 4e-20 Age at first birth; CRC cis rs6060717 0.702 rs6060756 chr20:34608479 A/G cg04508476 chr20:34239394 CPNE1;RBM12 0.4 6.38 0.33 6.1e-10 Hip circumference adjusted for BMI; CRC cis rs11758351 0.660 rs11753131 chr6:26219384 G/A cg01420254 chr6:26195488 NA 0.77 8.59 0.43 3.61e-16 Gout;Renal underexcretion gout; CRC cis rs9549367 0.713 rs11620600 chr13:113829090 G/A cg24300038 chr13:113819356 PROZ -0.47 -5.86 -0.31 1.13e-8 Platelet distribution width; CRC cis rs7412746 0.658 rs4970986 chr1:150907955 A/G cg15448220 chr1:150897856 SETDB1 0.56 8.23 0.41 4.44e-15 Melanoma; CRC cis rs2456568 0.709 rs1546400 chr11:93639203 G/A cg26875233 chr11:93583750 C11orf90 0.3 5.66 0.3 3.38e-8 Response to serotonin reuptake inhibitors in major depressive disorder; CRC cis rs2033711 0.870 rs1465789 chr19:58946056 C/T cg00825309 chr19:58991885 ZNF446 -0.4 -5.66 -0.3 3.23e-8 Uric acid clearance; CRC cis rs7737355 0.853 rs6596024 chr5:130769785 A/C cg25547332 chr5:131281432 NA 0.36 5.69 0.3 2.82e-8 Life satisfaction; CRC trans rs7647973 1.000 rs6805609 chr3:49471522 C/G cg02671819 chr17:62778370 LOC146880 -0.46 -6.11 -0.32 2.79e-9 Menarche (age at onset); CRC cis rs7618915 1.000 rs3852064 chr3:52349412 G/T cg14092988 chr3:52407081 DNAH1 0.41 7.5 0.38 6.19e-13 Bipolar disorder; CRC trans rs17270561 1.000 rs79867288 chr6:25828416 A/G cg14063357 chr9:79793314 VPS13A;LOC100286938 0.6 6.19 0.32 1.83e-9 Iron status biomarkers; CRC cis rs9443645 0.527 rs9343870 chr6:79789473 T/G cg05283184 chr6:79620031 NA -0.45 -6.44 -0.33 4.15e-10 Intelligence (multi-trait analysis); CRC cis rs11622475 1.000 rs2269186 chr14:104379912 C/T cg12183467 chr14:104352244 NA -0.52 -7.01 -0.36 1.34e-11 Bipolar disorder; CRC cis rs2535633 0.602 rs2581816 chr3:53014657 C/T cg11645453 chr3:52864694 ITIH4 0.4 7.44 0.38 8.58e-13 Body mass index; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg24662107 chr5:139135835 NA 0.43 6.11 0.32 2.74e-9 Anxiety disorder; CRC trans rs8002861 0.967 rs7994883 chr13:44478805 A/G cg17145862 chr1:211918768 LPGAT1 -0.77 -16.17 -0.67 1.04e-43 Leprosy; CRC cis rs861020 1.000 rs630984 chr1:209982293 C/T cg05527609 chr1:210001259 C1orf107 0.91 11.21 0.53 6.36e-25 Orofacial clefts; CRC cis rs13191362 1.000 rs35754151 chr6:163074867 A/G cg21926612 chr6:163149169 PACRG;PARK2 0.97 12.69 0.57 2.66e-30 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs7131987 0.868 rs10771508 chr12:29414211 G/A cg09582351 chr12:29534625 ERGIC2 -0.28 -6.02 -0.31 4.66e-9 QT interval; CRC cis rs12024301 0.557 rs115277680 chr1:183614362 T/G cg11505048 chr1:183622726 RGL1;APOBEC4 0.81 7.0 0.36 1.42e-11 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs62244186 1.000 rs62244186 chr3:44739783 G/A cg18722847 chr3:44754129 ZNF502 -0.34 -5.63 -0.3 3.82e-8 Depressive symptoms; CRC cis rs6942756 1.000 rs6980385 chr7:128943615 G/A cg02491457 chr7:128862824 NA -0.76 -10.46 -0.5 2.65e-22 White matter hyperintensity burden; CRC cis rs6988985 0.728 rs7003782 chr8:143974828 C/T cg10324643 chr8:143916377 GML 0.39 6.4 0.33 5.45e-10 Plasma androstenedione levels in resected early stage-receptor positive breast cancer; CRC cis rs7762018 1.000 rs6912959 chr6:170126224 G/A cg17545662 chr6:170176663 C6orf70 0.56 6.45 0.34 3.94e-10 Thiazide-induced adverse metabolic effects in hypertensive patients; CRC cis rs72945132 0.882 rs12278125 chr11:70134016 T/C cg14191688 chr11:70257035 CTTN 0.4 5.62 0.3 4.07e-8 Coronary artery disease; CRC cis rs4290604 0.748 rs10164697 chr2:238032560 G/A cg23555395 chr2:238036564 NA -0.66 -6.71 -0.35 8.36e-11 Asthma; CRC cis rs7621025 0.500 rs16844241 chr3:136635171 A/G cg15507776 chr3:136538369 TMEM22 -0.47 -7.03 -0.36 1.21e-11 C-reactive protein levels or HDL-cholesterol levels (pleiotropy);Body mass index; CRC cis rs9811920 0.609 rs10936005 chr3:99674093 G/A cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G -0.46 -6.09 -0.32 3.12e-9 Axial length; CRC cis rs10504229 0.769 rs17215649 chr8:58152791 A/G cg24829409 chr8:58192753 C8orf71 -0.58 -7.96 -0.4 2.86e-14 Developmental language disorder (linguistic errors); CRC cis rs1048238 0.506 rs10737911 chr1:16167855 C/T cg21385522 chr1:16154831 NA -0.57 -8.52 -0.43 5.74e-16 Systolic blood pressure; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg27114727 chr14:74227186 C14orf43 0.38 6.04 0.32 4.27e-9 Liver disease severity in Alagille syndrome; CRC cis rs7119 0.717 rs10519167 chr15:77723027 G/T cg17802220 chr15:77601643 NA -0.45 -6.46 -0.34 3.66e-10 Type 2 diabetes; CRC cis rs1552244 0.935 rs2272124 chr3:10138189 T/C cg18598329 chr3:10140678 FANCD2;C3orf24 -0.9 -13.35 -0.59 9.02e-33 Alzheimer's disease; CRC cis rs4563143 0.675 rs55884228 chr19:29243897 G/T cg12756686 chr19:29218302 NA 0.6 8.99 0.44 2.04e-17 Methadone dose in opioid dependence; CRC cis rs9611519 1.000 rs2057070 chr22:41564287 T/C cg06634786 chr22:41940651 POLR3H -0.47 -6.13 -0.32 2.44e-9 Neuroticism; CRC cis rs13217239 0.646 rs7451149 chr6:27057518 A/G cg12292205 chr6:26970375 C6orf41 -0.51 -8.34 -0.42 2.03e-15 Schizophrenia; CRC trans rs7726839 0.540 rs61731455 chr5:665295 A/G cg11887960 chr12:57824829 NA 0.66 7.1 0.36 7.76e-12 Obesity-related traits; CRC cis rs9811920 0.638 rs793440 chr3:99643176 C/T cg07805332 chr3:99536008 MIR548G;C3orf26 -0.54 -8.19 -0.41 5.93e-15 Axial length; CRC cis rs3820068 0.603 rs927207 chr1:15990552 A/G cg24675056 chr1:15929824 NA 0.52 6.9 0.36 2.64e-11 Systolic blood pressure; CRC cis rs447 0.945 rs4141151 chr7:83737361 A/G cg22846510 chr7:83753280 SEMA3A -0.55 -6.93 -0.36 2.28e-11 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs7772486 0.875 rs11755334 chr6:146399297 T/C cg13319975 chr6:146136371 FBXO30 -0.4 -6.17 -0.32 2.02e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs7843479 0.601 rs1058486 chr8:21862551 A/G cg17168535 chr8:21777572 XPO7 0.61 10.39 0.5 4.64e-22 Mean corpuscular volume; CRC cis rs3857067 0.806 rs72665608 chr4:95093501 T/C cg11021082 chr4:95130006 SMARCAD1 -0.49 -7.65 -0.39 2.22e-13 QT interval; CRC cis rs10426930 0.621 rs6510833 chr19:5008399 G/A cg18473234 chr19:5097819 KDM4B 0.59 6.32 0.33 8.28e-10 Monocyte percentage of white cells; CRC cis rs9612 1.000 rs28373139 chr19:44246706 A/G cg08581076 chr19:44259116 C19orf61 0.52 6.58 0.34 1.8e-10 Exhaled nitric oxide output; CRC cis rs17270561 0.609 rs9393658 chr6:25730438 C/T cg17691542 chr6:26056736 HIST1H1C 0.73 9.26 0.45 2.71e-18 Iron status biomarkers; CRC cis rs11229555 0.645 rs17474373 chr11:58191243 G/A cg15696309 chr11:58395628 NA -0.9 -11.45 -0.53 8.8e-26 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; CRC trans rs2303319 0.504 rs62189047 chr2:162613314 T/A cg25193742 chr10:104614220 C10orf32 -0.77 -6.51 -0.34 2.87e-10 Cognitive function; CRC cis rs10242455 0.702 rs73397481 chr7:99030108 C/T cg18809830 chr7:99032528 PTCD1 -1.19 -8.57 -0.43 4.21e-16 Blood metabolite levels; CRC cis rs6912958 0.559 rs242280 chr6:88048714 G/A cg08069147 chr6:88032118 GJB7;C6orf162 0.68 11.0 0.52 3.58e-24 Monocyte percentage of white cells; CRC cis rs35306767 0.903 rs7077278 chr10:911291 A/G cg20503657 chr10:835505 NA -0.91 -11.3 -0.53 3.11e-25 Eosinophil percentage of granulocytes; CRC cis rs17270561 0.609 rs4712961 chr6:25727334 C/T cg16482183 chr6:26056742 HIST1H1C 0.83 10.59 0.5 9.49e-23 Iron status biomarkers; CRC cis rs2569991 0.636 rs2600222 chr3:12937617 C/G cg22481960 chr3:13008800 IQSEC1 -0.51 -6.3 -0.33 9.63e-10 Periodontitis (DPAL); CRC cis rs9435341 0.965 rs1730859 chr1:107617707 A/G cg14671364 chr1:107599128 PRMT6 0.55 7.42 0.38 1e-12 Facial morphology (factor 21, depth of nasal alae); CRC cis rs7552404 0.961 rs1061337 chr1:76227022 A/G cg22875332 chr1:76189707 ACADM 0.7 9.59 0.47 2.33e-19 Blood metabolite levels;Acylcarnitine levels; CRC cis rs4713118 0.505 rs276371 chr6:27910708 A/T cg12172441 chr6:28176163 NA 0.42 5.73 0.3 2.29e-8 Parkinson's disease; CRC cis rs66782572 1 rs66782572 chr3:52567617 A/G cg17372223 chr3:52568218 NT5DC2 0.4 6.24 0.33 1.35e-9 Hemoglobin concentration; CRC trans rs1814175 0.645 rs10742953 chr11:49807491 C/G cg03929089 chr4:120376271 NA 0.92 15.42 0.65 9.76e-41 Height; CRC trans rs17270561 0.609 rs1165208 chr6:25803904 G/A cg02936872 chr9:99801550 CTSL2 0.47 6.13 0.32 2.48e-9 Iron status biomarkers; CRC cis rs597539 0.652 rs613128 chr11:68638058 G/T cg21963583 chr11:68658836 MRPL21 0.59 10.65 0.51 6e-23 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs8060686 0.841 rs56374641 chr16:67908713 G/T cg26727032 chr16:67993705 SLC12A4 -0.59 -7.18 -0.37 4.61e-12 HDL cholesterol;Metabolic syndrome; CRC cis rs6088580 0.570 rs6058057 chr20:33065283 G/A cg24642439 chr20:33292090 TP53INP2 0.37 6.23 0.32 1.41e-9 Glomerular filtration rate (creatinine); CRC cis rs728616 0.867 rs117139504 chr10:81734207 C/A cg05935833 chr10:81318306 SFTPA2 -0.76 -8.28 -0.42 3.12e-15 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs55871839 0.708 rs12115074 chr8:59817473 C/T cg07426533 chr8:59803705 TOX -0.32 -5.61 -0.3 4.27e-8 Pneumonia; CRC cis rs6963495 0.745 rs55906043 chr7:105165367 T/G cg02135003 chr7:105160482 PUS7 -0.91 -12.41 -0.56 2.87e-29 Bipolar disorder (body mass index interaction); CRC cis rs79387448 0.745 rs79107058 chr2:103164257 C/A cg00507830 chr2:103233733 NA 0.51 5.61 0.3 4.25e-8 Gut microbiota (bacterial taxa); CRC cis rs860295 0.651 rs6677385 chr1:155304581 C/A cg02153340 chr1:155202674 NA -0.51 -6.24 -0.33 1.36e-9 Body mass index; CRC cis rs6933660 0.745 rs9397405 chr6:151736084 G/T cg14262678 chr6:151773367 RMND1;C6orf211 0.5 8.15 0.41 7.77e-15 Menarche (age at onset); CRC trans rs2048656 0.523 rs1976673 chr8:9679780 T/A cg08975724 chr8:8085496 FLJ10661 0.45 6.38 0.33 5.96e-10 Schizophrenia; CRC cis rs644799 1.000 rs546809 chr11:95579938 A/G cg03916912 chr11:95522834 CEP57;FAM76B 0.96 18.46 0.71 9.75e-53 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg23151374 chr4:164415611 C4orf43 0.51 6.66 0.34 1.12e-10 Thyroid stimulating hormone; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg19082920 chr1:202830751 LOC148709 0.43 6.19 0.32 1.84e-9 Response to antipsychotic treatment; CRC cis rs9463078 0.550 rs7769231 chr6:45284921 A/G cg25276700 chr6:44698697 NA -0.25 -6.02 -0.31 4.74e-9 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; CRC cis rs3008870 0.959 rs2985808 chr1:67367741 T/C cg08660285 chr1:67390436 MIER1;WDR78 1.03 15.68 0.65 9.43e-42 Lymphocyte percentage of white cells; CRC cis rs6502050 0.835 rs9900128 chr17:80087920 A/T cg22110888 chr17:80059540 CCDC57 0.4 6.34 0.33 7.4e-10 Life satisfaction; CRC cis rs1552244 1.000 rs4260416 chr3:10125283 C/T cg18598329 chr3:10140678 FANCD2;C3orf24 -0.9 -12.83 -0.58 7.64e-31 Alzheimer's disease; CRC cis rs4727027 0.704 rs13229244 chr7:148898219 A/C cg23583168 chr7:148888333 NA 0.91 17.05 0.69 3.57e-47 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC cis rs9926296 0.548 rs6500439 chr16:89808275 A/C cg04287289 chr16:89883240 FANCA 0.81 14.27 0.62 2.66e-36 Vitiligo; CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg00619347 chr3:149688574 PFN2 0.36 6.0 0.31 5.1e-9 Obesity-related traits; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg25623535 chr19:41196524 NUMBL 0.47 6.66 0.34 1.16e-10 Anxiety disorder; CRC cis rs2576037 0.526 rs6507714 chr18:44519574 A/G cg24750912 chr18:44543259 TCEB3CL;KATNAL2 0.31 6.05 0.32 4.02e-9 Personality dimensions; CRC trans rs7395662 0.864 rs11039917 chr11:48695428 G/A cg21153622 chr11:89784906 NA -0.47 -7.44 -0.38 8.88e-13 HDL cholesterol; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg06463010 chr2:42795624 MTA3 -0.42 -6.27 -0.33 1.12e-9 Myopia (pathological); CRC cis rs2463822 1.000 rs2463822 chr11:62103420 T/C cg06239285 chr11:62104954 ASRGL1 1.07 11.84 0.55 3.54e-27 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs11585357 0.895 rs72633803 chr1:17616758 G/A cg08277548 chr1:17600880 PADI3 -0.89 -11.28 -0.53 3.61e-25 Hair shape; CRC cis rs262150 0.567 rs2527177 chr7:158804737 T/C cg19418458 chr7:158789849 NA -0.48 -8.23 -0.41 4.55e-15 Facial morphology (factor 20); CRC cis rs7949030 0.626 rs11231144 chr11:62328038 A/G cg13298116 chr11:62369859 EML3;MTA2 0.62 11.01 0.52 3.29e-24 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; CRC cis rs9894429 0.646 rs6565612 chr17:79602820 C/T cg21028142 chr17:79581711 NPLOC4 -0.34 -7.2 -0.37 4.03e-12 Eye color traits; CRC cis rs6754311 0.552 rs1030765 chr2:136553188 A/T cg15123519 chr2:136567270 LCT 0.31 5.9 0.31 9.24e-9 Mosquito bite size; CRC cis rs172166 0.561 rs149971 chr6:27982152 G/A cg06470822 chr6:28175283 NA 0.64 9.43 0.46 7.89e-19 Cardiac Troponin-T levels; CRC cis rs11864453 0.826 rs2074626 chr16:72139184 C/A cg23815491 chr16:72088622 HP 0.54 8.13 0.41 8.69e-15 Fibrinogen levels; CRC cis rs6952808 0.691 rs2398709 chr7:2112548 C/T cg22963979 chr7:1858916 MAD1L1 -0.5 -7.12 -0.37 7.03e-12 Bipolar disorder and schizophrenia; CRC cis rs10504229 0.683 rs1495866 chr8:58141128 T/C cg24829409 chr8:58192753 C8orf71 -0.55 -8.03 -0.4 1.71e-14 Developmental language disorder (linguistic errors); CRC trans rs6703335 0.870 rs10803142 chr1:243598234 A/G cg05873873 chr17:30771297 PSMD11 0.43 6.04 0.32 4.12e-9 Schizophrenia;Schizophrenia, schizoaffective disorder or bipolar disorder; CRC cis rs35306767 0.715 rs17221463 chr10:1038040 T/C cg20503657 chr10:835505 NA 0.93 11.22 0.53 5.92e-25 Eosinophil percentage of granulocytes; CRC cis rs9287719 0.934 rs10201077 chr2:10752426 A/C cg00105475 chr2:10696890 NA 0.45 7.17 0.37 4.85e-12 Prostate cancer; CRC cis rs6840360 0.533 rs13145446 chr4:152729035 G/A cg09659197 chr4:152720779 NA -0.41 -8.15 -0.41 7.55e-15 Intelligence (multi-trait analysis); CRC cis rs9393692 0.620 rs12525187 chr6:26337537 A/G cg00631329 chr6:26305371 NA -0.56 -9.48 -0.46 5.3e-19 Educational attainment; CRC cis rs1448094 0.511 rs6539921 chr12:86164163 G/A cg00310523 chr12:86230176 RASSF9 0.38 6.15 0.32 2.2e-9 Major depressive disorder; CRC cis rs2228479 0.764 rs7191836 chr16:89961597 T/C cg04013166 chr16:89971882 TCF25 0.59 6.52 0.34 2.68e-10 Skin colour saturation; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg17129141 chr2:47629949 MSH2 0.45 6.32 0.33 8.34e-10 Response to antipsychotic treatment; CRC cis rs7412746 0.611 rs4319334 chr1:150766822 G/A cg17724175 chr1:150552817 MCL1 0.46 6.99 0.36 1.55e-11 Melanoma; CRC cis rs10486722 0.651 rs10951655 chr7:41776877 A/C cg22138096 chr7:41772439 LOC285954 -0.5 -6.58 -0.34 1.85e-10 Pit-and-Fissure caries; CRC cis rs7615952 0.641 rs4422257 chr3:125774363 A/G cg05084668 chr3:125655381 ALG1L -0.45 -6.47 -0.34 3.59e-10 Blood pressure (smoking interaction); CRC cis rs9398803 0.865 rs1572569 chr6:126771687 G/A cg19875578 chr6:126661172 C6orf173 0.41 5.7 0.3 2.6e-8 Male-pattern baldness; CRC trans rs6550704 0.687 rs9865314 chr3:22634337 A/G cg00307073 chr7:116502428 CAPZA2 -0.43 -6.28 -0.33 1.08e-9 Daytime sleep phenotypes; CRC cis rs4563143 0.675 rs73029050 chr19:29276554 G/T cg12667521 chr19:29218732 NA 0.49 7.48 0.38 6.71e-13 Methadone dose in opioid dependence; CRC cis rs10189230 0.868 rs1367242 chr2:222353441 A/G cg14652038 chr2:222343519 EPHA4 0.52 10.02 0.48 8.14e-21 Urate levels in lean individuals; CRC cis rs2243480 0.901 rs35256305 chr7:65306405 T/C cg18252515 chr7:66147081 NA -1.17 -13.57 -0.6 1.26e-33 Diabetic kidney disease; CRC cis rs2841277 0.708 rs10083374 chr14:105402994 T/C cg14403583 chr14:105418241 AHNAK2 -0.33 -5.92 -0.31 8.24e-9 Rheumatoid arthritis; CRC cis rs4713118 0.869 rs9295742 chr6:27702832 G/A cg19041857 chr6:27730383 NA -0.41 -6.0 -0.31 5.3300000000000004e-09 Parkinson's disease; CRC cis rs1448094 0.511 rs17279289 chr12:86162792 T/G cg02569458 chr12:86230093 RASSF9 0.47 7.78 0.39 9.77e-14 Major depressive disorder; CRC cis rs9467711 0.591 rs116201501 chr6:25999149 C/T cg08501292 chr6:25962987 TRIM38 0.84 7.76 0.39 1.1e-13 Autism spectrum disorder or schizophrenia; CRC cis rs2302190 0.882 rs7209650 chr17:56674905 C/T cg12560992 chr17:57184187 TRIM37 0.52 6.11 0.32 2.82e-9 Vitamin D levels; CRC cis rs853679 0.760 rs11967137 chr6:28199764 A/G cg03623178 chr6:28175578 NA 0.75 7.86 0.4 5.45e-14 Depression; CRC cis rs1375194 0.606 rs935625 chr2:33811516 C/G cg04131969 chr2:33951647 MYADML -0.51 -7.54 -0.38 4.54e-13 Response to antidepressants in depression; CRC cis rs1577917 0.883 rs1337854 chr6:86724015 C/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A 0.45 5.93 0.31 7.72e-9 Response to antipsychotic treatment; CRC cis rs1031391 0.716 rs10772416 chr12:11170087 T/A cg25677688 chr12:11176386 TAS2R19;PRR4;PRH1 0.61 7.17 0.37 5.13e-12 Bitter taste perception; CRC cis rs9325144 0.555 rs2387843 chr12:38711203 T/C cg26384229 chr12:38710491 ALG10B 0.55 8.25 0.41 3.93e-15 Morning vs. evening chronotype; CRC cis rs10464366 0.957 rs11765705 chr7:39106942 G/T cg15212455 chr7:39170539 POU6F2 0.45 5.69 0.3 2.82e-8 IgG glycosylation; CRC cis rs4604732 0.574 rs111928142 chr1:247625229 G/T cg02104434 chr1:247694406 LOC148824;OR2C3 0.6 8.75 0.43 1.16e-16 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CRC trans rs61931739 0.500 rs7295779 chr12:34460652 T/C cg26384229 chr12:38710491 ALG10B 0.6 8.82 0.44 6.8e-17 Morning vs. evening chronotype; CRC cis rs17780086 0.527 rs72827712 chr17:30538600 A/G cg12193833 chr17:30244370 NA -0.71 -7.23 -0.37 3.45e-12 Height; CRC cis rs634534 0.622 rs501353 chr11:65739549 T/G cg26695010 chr11:65641043 EFEMP2 -0.4 -6.1 -0.32 2.94e-9 Sum eosinophil basophil counts;Eosinophil counts; CRC trans rs4824093 0.610 rs13340054 chr22:50311726 G/A cg09872104 chr7:134855509 C7orf49 -0.84 -8.02 -0.4 1.85e-14 Amyotrophic lateral sclerosis (sporadic); CRC cis rs11628318 0.853 rs7155171 chr14:103031845 C/T cg08075719 chr14:103021372 NA -0.7 -9.66 -0.47 1.36e-19 Platelet count; CRC cis rs2732480 0.577 rs2450994 chr12:48721832 G/A cg21466736 chr12:48725269 NA -0.59 -8.95 -0.44 2.63e-17 Hemoglobin concentration;Red blood cell count;Hematocrit; CRC trans rs7615952 0.800 rs12489350 chr3:125644116 T/C cg02560186 chr11:3602584 NA -0.45 -6.12 -0.32 2.64e-9 Blood pressure (smoking interaction); CRC cis rs7927592 0.956 rs948315 chr11:68309140 T/C cg16797656 chr11:68205561 LRP5 0.35 5.63 0.3 3.95e-8 Total body bone mineral density; CRC cis rs9911578 1.000 rs3744109 chr17:56594197 C/T cg05425664 chr17:57184151 TRIM37 0.51 8.14 0.41 8.43e-15 Intelligence (multi-trait analysis); CRC cis rs11098499 1.000 rs6837898 chr4:120179154 C/T cg24375607 chr4:120327624 NA 0.47 7.4 0.38 1.12e-12 Corneal astigmatism; CRC trans rs2727020 0.823 rs7102374 chr11:49261795 G/A cg15704280 chr7:45808275 SEPT13 0.68 9.35 0.46 1.41e-18 Coronary artery disease; CRC cis rs965469 1.000 rs6051827 chr20:3372007 C/T cg25506879 chr20:3388711 C20orf194 -0.4 -5.84 -0.31 1.28e-8 IFN-related cytopenia; CRC cis rs12291225 0.679 rs11023172 chr11:14295367 C/G cg19336497 chr11:14380999 RRAS2 -0.52 -8.62 -0.43 2.96e-16 Sense of smell; CRC cis rs8044995 0.501 rs7189887 chr16:68353915 C/T cg05110241 chr16:68378359 PRMT7 -0.71 -7.34 -0.37 1.74e-12 Schizophrenia; CRC cis rs1046896 0.512 rs3785513 chr17:80886748 G/A cg16060761 chr17:80687452 NA -0.55 -7.95 -0.4 3.08e-14 Glycated hemoglobin levels; CRC cis rs9443645 0.901 rs9443622 chr6:79582790 C/T cg09184832 chr6:79620586 NA -0.5 -9.44 -0.46 7.24e-19 Intelligence (multi-trait analysis); CRC cis rs10992471 0.729 rs2181585 chr9:95551830 G/A cg13798575 chr9:95087839 CENPP;NOL8 -0.42 -5.94 -0.31 7.33e-9 Visceral adipose tissue/subcutaneous adipose tissue ratio; CRC cis rs2816062 0.710 rs2816052 chr1:18895536 T/C cg18795169 chr1:18902165 NA -0.92 -19.57 -0.73 4.36e-57 Urate levels in lean individuals; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg07590406 chr3:58292066 RPP14 0.52 7.54 0.38 4.66e-13 Response to antipsychotic treatment; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg25109009 chr16:69760305 NQO1 0.45 6.71 0.35 8.42e-11 Intelligence (multi-trait analysis); CRC cis rs2576037 0.583 rs2187091 chr18:44520048 T/C cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.64 10.72 0.51 3.36e-23 Personality dimensions; CRC cis rs2976388 0.590 rs4736322 chr8:143822208 T/C cg04969067 chr8:143858791 LYNX1 -0.42 -6.66 -0.34 1.14e-10 Urinary tract infection frequency; CRC cis rs77633900 0.614 rs2468120 chr15:76909975 G/A cg21673338 chr15:77095150 SCAPER -0.72 -7.04 -0.36 1.16e-11 Non-glioblastoma glioma;Glioma; CRC cis rs867529 1.000 rs1606803 chr2:88933316 C/T cg26627705 chr2:89060884 NA -0.51 -6.48 -0.34 3.35e-10 Height; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg06394476 chr2:65454602 ACTR2 0.4 6.23 0.32 1.45e-9 Intelligence (multi-trait analysis); CRC cis rs9733 0.650 rs2048558 chr1:150571730 A/G cg17724175 chr1:150552817 MCL1 -0.51 -8.22 -0.41 4.74e-15 Tonsillectomy; CRC cis rs17685 0.712 rs10952842 chr7:75780413 G/A cg16489192 chr7:75678113 MDH2;STYXL1 -0.36 -5.71 -0.3 2.56e-8 Coffee consumption;Coffee consumption (cups per day); CRC cis rs877282 1.000 rs34257857 chr10:772993 C/A cg17470449 chr10:769945 NA 0.6 8.43 0.42 1.1e-15 Uric acid levels; CRC cis rs61612642 0.537 rs6915565 chr6:42192582 G/A cg10382835 chr6:42185730 MRPS10 0.66 6.5 0.34 2.92e-10 Eosinophil percentage of white cells;Sum eosinophil basophil counts;Eosinophil percentage of granulocytes;Eosinophil counts; CRC trans rs2832077 0.527 rs59730679 chr21:30226244 T/C cg14791747 chr16:20752902 THUMPD1 0.68 10.99 0.52 3.93e-24 Cognitive test performance; CRC cis rs9467711 0.606 rs2235251 chr6:26431982 C/T cg08501292 chr6:25962987 TRIM38 0.83 6.43 0.33 4.44e-10 Autism spectrum disorder or schizophrenia; CRC cis rs4843747 0.518 rs4072777 chr16:88107030 G/A cg17633681 chr16:88106987 BANP 0.87 16.24 0.67 5.81e-44 Menopause (age at onset); CRC cis rs28374715 0.532 rs28463309 chr15:41666716 A/G cg18705301 chr15:41695430 NDUFAF1 -1.1 -19.24 -0.73 8.17e-56 Ulcerative colitis; CRC cis rs2836950 0.520 rs8130240 chr21:40538108 G/A cg06238570 chr21:40685208 BRWD1 -0.63 -9.26 -0.45 2.81e-18 Menarche (age at onset); CRC cis rs4253772 0.637 rs9627295 chr22:46650100 C/T cg09491104 chr22:46646882 C22orf40 -0.48 -7.51 -0.38 5.72e-13 LDL cholesterol;Cholesterol, total; CRC cis rs561341 0.941 rs17780086 chr17:30343282 G/A cg19193384 chr17:30244184 NA -0.65 -7.54 -0.38 4.67e-13 Hip circumference adjusted for BMI; CRC cis rs67478160 0.704 rs12894254 chr14:104290949 G/C cg08213375 chr14:104286397 PPP1R13B 0.64 13.5 0.6 2.33e-33 Schizophrenia; CRC cis rs117623576 0.941 rs211422 chr10:32398589 A/G cg03047570 chr10:32398778 NA 0.8 8.68 0.43 1.83e-16 Anti-saccade response; CRC trans rs3733585 0.699 rs28613263 chr4:9964880 C/T cg26043149 chr18:55253948 FECH -0.49 -7.48 -0.38 6.69e-13 Cleft plate (environmental tobacco smoke interaction); CRC trans rs2228479 0.557 rs34420680 chr16:89809171 C/T cg21302420 chr1:112162376 RAP1A 0.77 6.26 0.33 1.19e-9 Skin colour saturation; CRC cis rs561341 1.000 rs117029332 chr17:30266085 C/G cg19193384 chr17:30244184 NA -0.65 -7.51 -0.38 5.54e-13 Hip circumference adjusted for BMI; CRC cis rs7829975 0.514 rs2979151 chr8:8258019 A/G cg06636001 chr8:8085503 FLJ10661 -0.65 -10.07 -0.49 5.53e-21 Mood instability; CRC cis rs12586317 0.513 rs11156871 chr14:35481196 G/A cg05294307 chr14:35346193 BAZ1A -0.72 -7.81 -0.4 7.98e-14 Psoriasis; CRC cis rs4713118 0.869 rs6456802 chr6:27698355 A/G cg15845792 chr6:28175446 NA 0.65 9.11 0.45 7.98e-18 Parkinson's disease; CRC cis rs634534 0.622 rs552130 chr11:65732800 T/C cg17985854 chr11:65770987 BANF1;EIF1AD 0.41 6.84 0.35 3.84e-11 Sum eosinophil basophil counts;Eosinophil counts; CRC cis rs1524976 1.000 rs7612710 chr3:65476581 C/T cg16238336 chr3:65465873 MAGI1 -0.52 -7.72 -0.39 1.44e-13 PR interval; CRC cis rs7258465 1.000 rs8111708 chr19:18558876 A/G cg10790698 chr19:18539756 SSBP4 -0.44 -8.12 -0.41 9.46e-15 Breast cancer; CRC cis rs2976388 0.533 rs12543368 chr8:143819450 T/C cg10596483 chr8:143751796 JRK -0.5 -6.79 -0.35 5.12e-11 Urinary tract infection frequency; CRC cis rs7119 0.651 rs35577135 chr15:77840074 C/T cg10437265 chr15:77819839 NA 0.66 11.29 0.53 3.25e-25 Type 2 diabetes; CRC trans rs57221529 0.713 rs72703072 chr5:590626 A/G cg11887960 chr12:57824829 NA 0.63 6.95 0.36 1.94e-11 Lung disease severity in cystic fibrosis; CRC cis rs6952808 1.000 rs4719319 chr7:1888094 G/A cg04267008 chr7:1944627 MAD1L1 -0.77 -11.12 -0.52 1.37e-24 Bipolar disorder and schizophrenia; CRC cis rs501120 1.000 rs501120 chr10:44753867 T/C cg09554077 chr10:44749378 NA 0.89 13.31 0.59 1.23e-32 Coronary artery disease;Coronary heart disease; CRC cis rs10905065 0.898 rs2892078 chr10:5831138 A/G cg11519256 chr10:5708881 ASB13 -0.44 -6.27 -0.33 1.11e-9 Menopause (age at onset); CRC cis rs7715806 0.500 rs888788 chr5:74988336 C/T cg00601450 chr5:74908170 NA 0.49 6.12 0.32 2.71e-9 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs72634258 0.519 rs4908708 chr1:7938113 G/C cg26816564 chr1:7831052 VAMP3 0.63 7.65 0.39 2.3e-13 Inflammatory bowel disease; CRC trans rs7824557 0.564 rs2043508 chr8:11227406 G/A cg06636001 chr8:8085503 FLJ10661 -0.48 -7.34 -0.38 1.73e-12 Retinal vascular caliber; CRC cis rs7493 1.000 rs17166875 chr7:95041271 C/T cg04155289 chr7:94953770 PON1 -0.6 -7.44 -0.38 8.8e-13 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs4862750 0.872 rs9998173 chr4:187898778 T/A cg10295955 chr4:187884368 NA -1.07 -28.67 -0.85 1.81e-91 Lobe attachment (rater-scored or self-reported); CRC cis rs9818758 0.607 rs56306491 chr3:49314960 G/A cg07636037 chr3:49044803 WDR6 -0.85 -6.5 -0.34 3.06e-10 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; CRC cis rs1552244 0.572 rs3894321 chr3:10168892 A/C cg18598329 chr3:10140678 FANCD2;C3orf24 -0.87 -10.35 -0.5 6.22e-22 Alzheimer's disease; CRC cis rs2932538 0.961 rs4838960 chr1:113163632 G/T cg22162597 chr1:113214053 CAPZA1 -0.61 -8.97 -0.44 2.36e-17 Systolic blood pressure;Diastolic blood pressure;Hypertension;Blood pressure; CRC cis rs10504229 0.683 rs16921823 chr8:58108612 G/C cg22535103 chr8:58192502 C8orf71 -0.68 -8.76 -0.43 1.08e-16 Developmental language disorder (linguistic errors); CRC cis rs282587 0.502 rs393320 chr13:113396469 C/A cg04656015 chr13:113407548 ATP11A 0.63 7.8 0.4 8.04e-14 Glycated hemoglobin levels; CRC cis rs3823572 0.504 rs2346266 chr7:133639533 A/G cg03336402 chr7:133662267 EXOC4 0.66 10.14 0.49 3.29e-21 Intelligence (multi-trait analysis); CRC cis rs4970988 0.607 rs7548516 chr1:150980281 C/T cg10589385 chr1:150898437 SETDB1 -0.32 -5.71 -0.3 2.46e-8 Urate levels; CRC cis rs2075371 0.897 rs1646702 chr7:134000177 C/G cg11752832 chr7:134001865 SLC35B4 0.5 7.63 0.39 2.52e-13 Mean platelet volume; CRC cis rs2354432 1.000 rs11239944 chr1:146691015 C/T cg25205988 chr1:146714368 CHD1L 0.97 11.02 0.52 3.12e-24 Mitochondrial DNA levels; CRC cis rs6840360 0.558 rs2709821 chr4:152342190 C/T cg09659197 chr4:152720779 NA 0.35 6.96 0.36 1.89e-11 Intelligence (multi-trait analysis); CRC cis rs11168351 0.750 rs11168366 chr12:48421773 T/C cg15465823 chr12:48382534 COL2A1 -0.38 -6.17 -0.32 2.04e-9 Bipolar disorder and schizophrenia; CRC cis rs17401966 0.838 rs55676616 chr1:10290126 T/C cg19773385 chr1:10388646 KIF1B -0.62 -9.42 -0.46 8.14e-19 Hepatocellular carcinoma; CRC cis rs2108622 0.727 rs77780918 chr19:15982707 T/C cg13772218 chr19:15982569 NA 0.49 7.01 0.36 1.39e-11 Circulating phylloquinone levels;Vitamin E levels;Acenocoumarol maintenance dosage;Response to Vitamin E supplementation;Metabolite levels;Warfarin maintenance dose; CRC cis rs904251 0.561 rs1757189 chr6:37483727 G/C cg01843034 chr6:37503916 NA -0.39 -7.12 -0.37 6.8e-12 Cognitive performance; CRC cis rs8072100 0.582 rs3826536 chr17:45501967 T/A cg25173405 chr17:45401733 C17orf57 -0.43 -6.45 -0.34 4.01e-10 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs55702914 0.712 rs12619296 chr2:198148767 A/G cg10820045 chr2:198174542 NA -0.39 -7.11 -0.36 7.22e-12 Major depression and alcohol dependence; CRC cis rs10540 1.000 rs12417570 chr11:462684 C/T cg03934478 chr11:495069 RNH1 0.69 7.12 0.37 6.61e-12 Body mass index; CRC cis rs9640161 0.830 rs3757424 chr7:150067679 C/A cg13722127 chr7:150037890 RARRES2 0.36 5.84 0.31 1.28e-8 Blood protein levels;Circulating chemerin levels; CRC cis rs7666738 0.830 rs11735193 chr4:98761900 C/T cg17366294 chr4:99064904 C4orf37 0.42 6.91 0.36 2.59e-11 Colonoscopy-negative controls vs population controls; CRC cis rs13256369 1.000 rs13271966 chr8:8575472 T/C cg06671706 chr8:8559999 CLDN23 0.54 8.15 0.41 7.85e-15 Obesity-related traits; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg07556773 chr1:155294010 RUSC1;C1orf104 0.4 6.47 0.34 3.56e-10 Liver disease severity in Alagille syndrome; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg00764470 chr14:31495561 AP4S1;STRN3 0.44 6.22 0.32 1.51e-9 Response to antipsychotic treatment; CRC cis rs7666738 0.962 rs2865986 chr4:99067907 A/G cg03676636 chr4:99064102 C4orf37 0.22 5.91 0.31 8.47e-9 Colonoscopy-negative controls vs population controls; CRC cis rs12476592 0.602 rs262495 chr2:63848607 G/A cg10828910 chr2:63850056 LOC388955 0.49 6.19 0.32 1.76e-9 Childhood ear infection; CRC trans rs2303319 0.504 rs58622044 chr2:162596287 A/G cg09481857 chr22:21368659 P2RX6;MGC16703 -0.65 -6.34 -0.33 7.73e-10 Cognitive function; CRC cis rs1153858 1.000 rs12101539 chr15:45650666 C/G cg10760299 chr15:45669010 GATM 0.51 8.14 0.41 8.37e-15 Homoarginine levels; CRC cis rs262150 0.704 rs2730236 chr7:158765543 C/T cg07130601 chr7:158766826 NA 0.42 6.02 0.32 4.59e-9 Facial morphology (factor 20); CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg25595571 chr14:104029029 BAG5;C14orf153 -0.41 -6.13 -0.32 2.45e-9 Myopia (pathological); CRC cis rs78456975 0.943 rs10470006 chr2:1580971 A/C cg26248373 chr2:1572462 NA -0.67 -8.16 -0.41 7.34e-15 Placebo response in major depressive disorder (% change in symptom score); CRC cis rs736408 0.648 rs3774354 chr3:52817675 G/A cg18404041 chr3:52824283 ITIH1 -0.45 -8.87 -0.44 4.84e-17 Bipolar disorder; CRC cis rs7833986 0.501 rs72653948 chr8:56955689 A/G cg23139584 chr8:56987506 RPS20;SNORD54 0.83 11.72 0.54 9.59e-27 Height; CRC cis rs1862618 0.802 rs832547 chr5:56183941 C/G cg12311346 chr5:56204834 C5orf35 -0.79 -10.04 -0.48 7.48e-21 Initial pursuit acceleration; CRC cis rs10791323 0.569 rs10736608 chr11:133740048 C/T cg06766960 chr11:133703094 NA -0.35 -6.44 -0.33 4.29e-10 Childhood ear infection; CRC cis rs7927771 0.542 rs3886262 chr11:47817010 T/G cg20307385 chr11:47447363 PSMC3 0.46 6.58 0.34 1.83e-10 Subjective well-being; CRC cis rs7107174 0.901 rs10899500 chr11:78125246 A/G cg02023728 chr11:77925099 USP35 0.44 6.87 0.35 3.3e-11 Testicular germ cell tumor; CRC cis rs4727027 0.840 rs12670633 chr7:148796707 G/A cg12479418 chr7:148823350 ZNF425;ZNF398 0.47 6.3 0.33 9.5e-10 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC cis rs769267 0.965 rs2074550 chr19:19387743 A/C cg01262667 chr19:19385393 TM6SF2 0.36 5.95 0.31 7.04e-9 Tonsillectomy; CRC cis rs9311474 0.508 rs6788887 chr3:52605005 T/C cg15147215 chr3:52552868 STAB1 -0.65 -11.29 -0.53 3.36e-25 Electroencephalogram traits; CRC cis rs9326248 0.906 rs171052 chr11:117081763 C/G cg11861562 chr11:117069780 TAGLN -0.44 -9.74 -0.47 7.41e-20 Blood protein levels; CRC cis rs67311347 1.000 rs13324109 chr3:40460767 T/C cg24209194 chr3:40518798 ZNF619 0.43 6.54 0.34 2.32e-10 Renal cell carcinoma; CRC cis rs1403694 0.695 rs1523435 chr3:186436306 G/A cg04611788 chr3:186434169 KNG1 -0.59 -8.78 -0.44 8.92e-17 Blood protein levels; CRC cis rs2404602 0.692 rs12910382 chr15:77053442 A/C cg03037974 chr15:76606532 NA 0.69 11.69 0.54 1.23e-26 Blood metabolite levels; CRC cis rs2228479 0.618 rs34689166 chr16:89860697 C/T cg19635926 chr16:89946313 TCF25 0.67 6.25 0.33 1.25e-9 Skin colour saturation; CRC cis rs17826219 0.500 rs2874724 chr17:29072433 T/C cg13385521 chr17:29058706 SUZ12P 0.72 8.17 0.41 6.77e-15 Body mass index; CRC cis rs13256369 0.802 rs1060107 chr8:8561399 G/T cg17143192 chr8:8559678 CLDN23 0.5 6.44 0.33 4.22e-10 Obesity-related traits; CRC cis rs35520189 0.591 rs6723582 chr2:113708102 A/G cg12858261 chr2:113808755 IL1F8 0.42 5.74 0.3 2.16e-8 Obstructive sleep apnea trait (apnea hypopnea index); CRC cis rs2976388 0.609 rs2572908 chr8:143802636 A/G cg22687807 chr8:143858763 LYNX1 0.48 8.58 0.43 3.68e-16 Urinary tract infection frequency; CRC cis rs3087591 0.708 rs7503922 chr17:29641935 C/A cg24425628 chr17:29625626 OMG;NF1 0.73 13.08 0.58 9.12e-32 Hip circumference; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg09623457 chr3:183735666 ABCC5 0.43 6.72 0.35 7.84e-11 Liver disease severity in Alagille syndrome; CRC cis rs881375 0.967 rs10739579 chr9:123694788 C/A cg14255062 chr9:123606675 PSMD5;LOC253039 0.4 5.81 0.31 1.47e-8 Rheumatoid arthritis; CRC cis rs12928939 0.911 rs11645704 chr16:71826611 G/T cg03805757 chr16:71968109 PKD1L3 -0.47 -6.06 -0.32 3.75e-9 Post bronchodilator FEV1; CRC cis rs4780401 0.933 rs8058003 chr16:11815178 C/T cg01061890 chr16:11836724 TXNDC11 -0.41 -5.61 -0.3 4.32e-8 Rheumatoid arthritis; CRC cis rs9311474 0.713 rs352169 chr3:52236762 C/T cg15147215 chr3:52552868 STAB1 -0.51 -8.24 -0.41 4e-15 Electroencephalogram traits; CRC cis rs7945705 0.902 rs1560569 chr11:8939887 C/T cg12365402 chr11:9010492 NRIP3 -0.44 -7.06 -0.36 9.72e-12 Hemoglobin concentration; CRC cis rs921968 0.643 rs3931102 chr2:219520405 C/T cg02176678 chr2:219576539 TTLL4 0.51 8.22 0.41 4.65e-15 Mean corpuscular hemoglobin concentration; CRC cis rs4676482 0.836 rs75370740 chr3:39233198 G/T cg02254461 chr3:39195904 CSRNP1 0.53 6.57 0.34 1.93e-10 Colonoscopy-negative controls vs population controls; CRC cis rs4664293 0.625 rs62171654 chr2:160531618 T/A cg08347373 chr2:160653686 CD302 0.39 6.52 0.34 2.67e-10 Monocyte percentage of white cells; CRC cis rs4665809 1.000 rs4665304 chr2:26313406 C/T cg25036284 chr2:26402008 FAM59B -0.46 -6.15 -0.32 2.27e-9 Gut microbiome composition (summer); CRC cis rs9649213 0.593 rs6465667 chr7:97957885 G/A cg00277769 chr7:97922759 BAIAP2L1 -0.61 -10.65 -0.51 5.74e-23 Prostate cancer (SNP x SNP interaction); CRC cis rs7619833 0.542 rs11129287 chr3:27497310 C/T cg02860705 chr3:27208620 NA 0.43 6.75 0.35 6.64e-11 Breast cancer; CRC cis rs798766 1.000 rs1374469 chr4:1724799 C/T cg05874882 chr4:1763078 NA -0.38 -7.0 -0.36 1.46e-11 Bladder cancer;Urinary bladder cancer; CRC cis rs6424115 0.830 rs1130321 chr1:24200524 C/T cg10978503 chr1:24200527 CNR2 0.61 11.06 0.52 2.22e-24 Immature fraction of reticulocytes; CRC cis rs447 0.945 rs13310638 chr7:83761086 A/G cg22846510 chr7:83753280 SEMA3A -0.6 -7.79 -0.39 8.68e-14 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC trans rs2470578 0.716 rs2733514 chr3:17323931 A/G cg19793718 chr12:125473601 DHX37 -0.44 -6.27 -0.33 1.12e-9 Schizophrenia; CRC cis rs9457247 0.534 rs9355610 chr6:167383075 G/A cg23791538 chr6:167370224 RNASET2 0.5 7.72 0.39 1.4e-13 Crohn's disease; CRC trans rs877282 0.583 rs10904562 chr10:819058 T/C cg22713356 chr15:30763199 NA 0.87 9.74 0.47 7.25e-20 Uric acid levels; CRC cis rs10504229 0.683 rs56208052 chr8:58130207 A/T cg21724239 chr8:58056113 NA 0.49 6.81 0.35 4.75e-11 Developmental language disorder (linguistic errors); CRC trans rs944990 0.595 rs10123378 chr9:96375217 C/T cg00012762 chr17:72744649 SLC9A3R1 0.42 6.41 0.33 5.05e-10 Body mass index; CRC cis rs11628318 0.508 rs3950014 chr14:103069889 G/A cg12046867 chr14:103022105 NA -0.77 -9.19 -0.45 4.41e-18 Platelet count; CRC cis rs875971 1.000 rs6958484 chr7:65599446 G/A cg00343986 chr7:65444356 GUSB -0.45 -6.64 -0.34 1.27e-10 Aortic root size; CRC cis rs2976388 0.609 rs2572907 chr8:143801938 G/A cg20041105 chr8:143859282 LYNX1 0.43 7.62 0.39 2.65e-13 Urinary tract infection frequency; CRC cis rs4957048 0.577 rs56294732 chr5:568144 T/C cg09021430 chr5:549028 NA -0.85 -11.06 -0.52 2.21e-24 Ulcerative colitis; CRC cis rs9814567 1.000 rs6806417 chr3:134211446 C/T cg06109529 chr3:134205091 CEP63;ANAPC13 0.79 11.98 0.55 1.11e-27 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs9916302 0.851 rs12947620 chr17:37605364 T/C cg00129232 chr17:37814104 STARD3 -0.55 -8.17 -0.41 6.79e-15 Glomerular filtration rate (creatinine); CRC cis rs9914988 0.778 rs9907192 chr17:27122426 C/G cg20469991 chr17:27169893 C17orf63 -0.6 -7.27 -0.37 2.59e-12 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs747650 0.504 rs7130947 chr11:47002005 C/A cg19486271 chr11:47235900 DDB2 -0.43 -6.49 -0.34 3.13e-10 Acne (severe); CRC cis rs921968 0.643 rs2278530 chr2:219501133 G/A cg02176678 chr2:219576539 TTLL4 0.49 7.82 0.4 7.21e-14 Mean corpuscular hemoglobin concentration; CRC cis rs875971 0.706 rs1643374 chr7:65872682 T/A cg11764359 chr7:65958608 NA 0.55 8.43 0.42 1.12e-15 Aortic root size; CRC cis rs2932538 0.922 rs999923 chr1:113110548 T/C cg22162597 chr1:113214053 CAPZA1 0.71 10.25 0.49 1.43e-21 Systolic blood pressure;Diastolic blood pressure;Hypertension;Blood pressure; CRC cis rs13191362 1.000 rs13220048 chr6:163004325 T/A cg23758597 chr6:163146217 PARK2 -0.55 -6.13 -0.32 2.54e-9 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs447 1.000 rs6964546 chr7:83750271 T/C cg22846510 chr7:83753280 SEMA3A -0.6 -7.79 -0.39 8.91e-14 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs10504229 0.638 rs6981055 chr8:58113941 T/C cg05313129 chr8:58192883 C8orf71 -0.43 -6.0 -0.31 5.07e-9 Developmental language disorder (linguistic errors); CRC cis rs6543140 0.964 rs11903551 chr2:103084181 C/G cg04239558 chr2:103089729 SLC9A4 0.37 6.61 0.34 1.51e-10 Blood protein levels; CRC cis rs8031584 0.678 rs798125 chr15:31116800 C/T cg08109568 chr15:31115862 NA 0.64 10.03 0.48 7.72e-21 Huntington's disease progression; CRC cis rs12580194 0.593 rs61957946 chr12:55755778 T/C cg19537932 chr12:55886519 OR6C68 -0.72 -9.07 -0.45 1.12e-17 Cancer; CRC cis rs17666538 0.585 rs336444 chr8:633123 C/G cg02524346 chr8:600233 NA -0.79 -8.9 -0.44 3.86e-17 IgG glycosylation; CRC cis rs2274273 1.000 rs61508494 chr14:55587297 T/C cg23234261 chr14:55582407 NA -0.29 -5.8 -0.3 1.58e-8 Protein biomarker; CRC cis rs2952156 0.959 rs2517956 chr17:37843859 G/A cg11212589 chr17:38028394 ZPBP2 0.35 5.94 0.31 7.37e-9 Asthma; CRC cis rs3857536 0.813 rs7743965 chr6:66941346 C/G cg07460842 chr6:66804631 NA -0.43 -5.81 -0.3 1.48e-8 Blood trace element (Cu levels); CRC cis rs57221529 0.545 rs55955015 chr5:575182 A/G cg17948913 chr5:572064 NA 0.55 6.3 0.33 9.64e-10 Lung disease severity in cystic fibrosis; CRC cis rs2153535 0.580 rs1115079 chr6:8449615 G/C cg07606381 chr6:8435919 SLC35B3 0.68 10.85 0.51 1.22e-23 Motion sickness; CRC cis rs875971 0.862 rs6460282 chr7:65691246 T/C cg18252515 chr7:66147081 NA 0.4 5.68 0.3 2.92e-8 Aortic root size; CRC cis rs734999 0.967 rs6671426 chr1:2504234 C/A cg18854424 chr1:2615690 NA 0.4 7.52 0.38 5.1e-13 Ulcerative colitis; CRC cis rs4665809 0.938 rs35844686 chr2:26304949 A/G cg22920501 chr2:26401640 FAM59B 0.56 6.73 0.35 7.73e-11 Gut microbiome composition (summer); CRC cis rs35883536 0.647 rs34195036 chr1:101040429 C/A cg06223162 chr1:101003688 GPR88 -0.35 -6.38 -0.33 5.94e-10 Monocyte count; CRC cis rs769267 1.000 rs12985655 chr19:19442434 G/A cg01262667 chr19:19385393 TM6SF2 -0.38 -6.3 -0.33 9.6e-10 Tonsillectomy; CRC cis rs2730245 0.527 rs2709858 chr7:158675266 C/G cg24397884 chr7:158709396 WDR60 0.94 11.43 0.53 1.05e-25 Height; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg06169648 chr16:85646832 KIAA0182 0.49 6.25 0.33 1.28e-9 Thyroid stimulating hormone; CRC cis rs12291225 0.679 rs4757245 chr11:14297872 A/C cg05501817 chr11:14380813 RRAS2 -0.45 -5.96 -0.31 6.43e-9 Sense of smell; CRC trans rs61931739 0.517 rs1844525 chr12:34103183 T/A cg26384229 chr12:38710491 ALG10B 0.54 6.95 0.36 1.99e-11 Morning vs. evening chronotype; CRC cis rs992157 0.700 rs10165153 chr2:219159629 T/C cg00012203 chr2:219082015 ARPC2 0.46 6.92 0.36 2.36e-11 Colorectal cancer; CRC cis rs16975963 0.895 rs8103383 chr19:38327701 A/C cg15135657 chr19:38346511 NA -0.43 -5.9 -0.31 8.84e-9 Longevity; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg18805835 chr5:138775054 DNAJC18 0.5 6.77 0.35 5.89e-11 Thyroid stimulating hormone; CRC cis rs11098499 0.908 rs1002152 chr4:120273387 C/A cg09307838 chr4:120376055 NA 0.69 10.4 0.5 4.27e-22 Corneal astigmatism; CRC cis rs739401 0.611 rs7130841 chr11:3043658 A/G cg05729581 chr11:3078854 CARS -0.58 -8.7 -0.43 1.66e-16 Longevity; CRC cis rs9322193 0.923 rs2297928 chr6:150039720 G/C cg00933542 chr6:150070202 PCMT1 0.31 6.38 0.33 6.16e-10 Lung cancer; CRC cis rs270601 0.661 rs10036208 chr5:131571323 T/C cg22638593 chr5:131593259 PDLIM4 0.53 9.23 0.45 3.51e-18 Acylcarnitine levels; CRC cis rs7662987 0.517 rs2924580 chr4:100032168 C/G cg12011299 chr4:100065546 ADH4 0.48 9.09 0.45 9.58e-18 Smoking initiation; CRC cis rs875971 0.545 rs3936065 chr7:65790564 C/T cg05627663 chr7:65219948 SNORA22;CCT6P1 0.61 7.87 0.4 5.25e-14 Aortic root size; CRC cis rs2530545 0.502 rs76161392 chr7:34680367 T/C cg14401837 chr7:34697493 NPSR1 0.6 5.78 0.3 1.74e-8 IgG glycosylation; CRC trans rs561341 1.000 rs473356 chr17:30321762 G/C cg27661571 chr11:113659931 NA -0.95 -10.99 -0.52 3.76e-24 Hip circumference adjusted for BMI; CRC cis rs2952156 0.834 rs903503 chr17:37829571 C/A cg07936489 chr17:37558343 FBXL20 -0.42 -5.97 -0.31 6.2e-9 Asthma; CRC cis rs6951245 0.638 rs74976697 chr7:1160505 C/T cg26224354 chr7:1096374 C7orf50;GPR146 -0.82 -10.92 -0.52 6.6e-24 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg10993769 chr22:39928308 RPS19BP1 0.45 6.32 0.33 8.38e-10 Response to antipsychotic treatment; CRC cis rs6952808 0.964 rs6945719 chr7:1932688 G/A cg14004847 chr7:1930337 MAD1L1 -0.42 -5.65 -0.3 3.4e-8 Bipolar disorder and schizophrenia; CRC trans rs11466653 1.000 rs9999985 chr4:38779091 A/G cg11403706 chr22:49042600 FAM19A5 0.62 6.11 0.32 2.76e-9 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs1153858 1.000 rs16942568 chr15:45677390 T/C cg10760299 chr15:45669010 GATM 0.5 7.9 0.4 4.16e-14 Homoarginine levels; CRC cis rs6951245 0.935 rs11766669 chr7:1063593 C/T cg18402987 chr7:1209562 NA 0.61 6.48 0.34 3.35e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs2415984 0.622 rs12437018 chr14:46937149 A/G cg14871534 chr14:47121158 RPL10L -0.41 -6.04 -0.32 4.2e-9 Number of children ever born; CRC cis rs6088590 1.000 rs6119524 chr20:33373813 C/T cg24642439 chr20:33292090 TP53INP2 0.59 10.54 0.5 1.46e-22 Coronary artery disease; CRC cis rs7666738 0.830 rs13110498 chr4:98959150 G/A cg17366294 chr4:99064904 C4orf37 0.43 7.34 0.38 1.69e-12 Colonoscopy-negative controls vs population controls; CRC cis rs875971 0.862 rs801206 chr7:66021966 C/G cg00343986 chr7:65444356 GUSB -0.44 -6.16 -0.32 2.16e-9 Aortic root size; CRC trans rs2303319 0.504 rs62189051 chr2:162622318 G/A cg18122310 chr12:50236657 BCDIN3D -0.73 -6.35 -0.33 7.23e-10 Cognitive function; CRC cis rs1552244 0.808 rs17032306 chr3:10091399 C/G cg10729496 chr3:10149963 C3orf24 0.5 6.78 0.35 5.69e-11 Alzheimer's disease; CRC trans rs7824557 0.603 rs2250028 chr8:11213589 T/G cg16141378 chr3:129829833 LOC729375 -0.44 -6.64 -0.34 1.27e-10 Retinal vascular caliber; CRC cis rs1552244 1.000 rs61077902 chr3:10126153 T/G cg13047869 chr3:10149882 C3orf24 0.56 7.75 0.39 1.12e-13 Alzheimer's disease; CRC trans rs9545047 0.716 rs9545067 chr13:79897564 A/G cg07061582 chr15:90234082 PEX11A;WDR93 0.42 6.07 0.32 3.47e-9 Schizophrenia; CRC cis rs7580658 0.929 rs4150477 chr2:128032546 A/G cg09760422 chr2:128146352 NA 0.38 7.47 0.38 7.36e-13 Protein C levels; CRC cis rs3806843 1.000 rs11167600 chr5:140174865 G/C cg19875535 chr5:140030758 IK 0.63 10.26 0.49 1.35e-21 Depressive symptoms (multi-trait analysis); CRC cis rs12701220 0.522 rs868833 chr7:1054973 C/G cg02733842 chr7:1102375 C7orf50 -0.44 -5.95 -0.31 6.68e-9 Bronchopulmonary dysplasia; CRC cis rs1448094 0.817 rs11117115 chr12:86331021 A/G cg02569458 chr12:86230093 RASSF9 0.46 7.68 0.39 1.89e-13 Major depressive disorder; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg04768630 chr22:35696543 TOM1 0.48 7.01 0.36 1.35e-11 Intelligence (multi-trait analysis); CRC cis rs2160860 0.765 rs55818481 chr8:39800041 A/C cg11363097 chr8:39792086 IDO2 -0.45 -7.65 -0.39 2.28e-13 Blood metabolite levels; CRC cis rs7584330 0.666 rs72620817 chr2:238353661 C/T cg16989719 chr2:238392110 NA -0.4 -6.45 -0.34 3.92e-10 Prostate cancer; CRC cis rs2120019 0.935 rs8042409 chr15:75350433 G/A cg09165964 chr15:75287851 SCAMP5 -0.83 -12.75 -0.58 1.52e-30 Blood trace element (Zn levels); CRC cis rs9372498 0.536 rs9489457 chr6:118920285 C/T cg10217327 chr6:118973057 C6orf204 0.52 5.92 0.31 8.31e-9 Diastolic blood pressure; CRC cis rs11122272 0.735 rs2572253 chr1:231512768 C/A cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.54 -8.11 -0.41 1.04e-14 Hemoglobin concentration; CRC trans rs208515 0.556 rs12201658 chr6:66678457 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.9 11.4 0.53 1.3e-25 Exhaled nitric oxide levels; CRC cis rs2836974 0.897 rs35391055 chr21:40525516 G/A cg17971929 chr21:40555470 PSMG1 0.84 12.96 0.58 2.62e-31 Cognitive function; CRC cis rs11676348 0.846 rs6723449 chr2:218997580 C/T cg00012203 chr2:219082015 ARPC2 0.42 6.21 0.32 1.6e-9 Ulcerative colitis; CRC cis rs9902453 0.808 rs76515799 chr17:28169491 A/G cg26525008 chr17:28256777 EFCAB5;SSH2 0.59 8.8 0.44 7.81e-17 Coffee consumption (cups per day); CRC cis rs6582630 0.598 rs11182207 chr12:38477514 T/C cg13010199 chr12:38710504 ALG10B -0.41 -5.92 -0.31 8.18e-9 Drug-induced liver injury (flucloxacillin); CRC cis rs801193 0.569 rs881285 chr7:66119420 A/G cg18252515 chr7:66147081 NA 0.44 6.2 0.32 1.72e-9 Aortic root size; CRC cis rs5753037 0.543 rs140126 chr22:30147038 A/G cg01021169 chr22:30184971 ASCC2 -0.37 -5.79 -0.3 1.65e-8 Type 1 diabetes; CRC cis rs10504229 1.000 rs6989060 chr8:58178989 T/G cg22535103 chr8:58192502 C8orf71 -0.82 -12.27 -0.56 9.63e-29 Developmental language disorder (linguistic errors); CRC cis rs9322193 0.962 rs9689447 chr6:150110486 T/A cg07701084 chr6:150067640 NUP43 0.47 6.61 0.34 1.51e-10 Lung cancer; CRC cis rs6964587 1.000 rs2299239 chr7:91654617 C/T cg17063962 chr7:91808500 NA 0.8 14.08 0.61 1.48e-35 Breast cancer; CRC cis rs2067615 0.524 rs4964483 chr12:107099057 T/C cg13491945 chr12:107078410 RFX4 0.37 6.28 0.33 1.08e-9 Heart rate; CRC cis rs17401966 0.931 rs3748577 chr1:10357406 C/T cg19773385 chr1:10388646 KIF1B 0.65 10.63 0.51 6.76e-23 Hepatocellular carcinoma; CRC cis rs4862750 0.872 rs6811569 chr4:187897988 A/G cg24874828 chr4:187887005 NA 0.34 5.76 0.3 1.95e-8 Lobe attachment (rater-scored or self-reported); CRC cis rs11608355 0.846 rs12581637 chr12:109855429 G/A cg19025524 chr12:109796872 NA -0.45 -5.97 -0.31 6.14e-9 Neuroticism; CRC cis rs6570726 0.791 rs414297 chr6:145887556 C/T cg13319975 chr6:146136371 FBXO30 -0.4 -5.92 -0.31 8.19e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs9814567 0.762 rs13070654 chr3:134219348 T/C cg06109529 chr3:134205091 CEP63;ANAPC13 0.7 8.78 0.44 9.26e-17 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs4713118 0.869 rs9283881 chr6:27715255 A/T cg21251018 chr6:28226885 NKAPL 0.38 5.74 0.3 2.13e-8 Parkinson's disease; CRC cis rs8018808 0.935 rs8005759 chr14:77880493 C/T cg20045696 chr14:77926864 AHSA1 0.36 5.6 0.3 4.51e-8 Myeloid white cell count; CRC cis rs2576037 0.583 rs8096263 chr18:44515216 C/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.62 10.42 0.5 3.69e-22 Personality dimensions; CRC cis rs7589728 0.514 rs78204719 chr2:88460747 G/C cg24977027 chr2:88469347 THNSL2 0.62 7.48 0.38 6.78e-13 Plasma clusterin levels; CRC cis rs727505 1.000 rs28844358 chr7:124562695 A/C cg23710748 chr7:124431027 NA -0.8 -14.11 -0.61 1.15e-35 Lewy body disease; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg01777103 chr8:145550585 DGAT1 -0.4 -6.17 -0.32 2.04e-9 Myopia (pathological); CRC cis rs9435341 0.930 rs12408634 chr1:107579540 G/A cg15468180 chr1:107600409 PRMT6 0.43 6.44 0.33 4.32e-10 Facial morphology (factor 21, depth of nasal alae); CRC cis rs1186222 0.521 rs4731230 chr7:75264429 C/T cg05145297 chr7:75264568 HIP1 0.68 12.17 0.56 2.23e-28 Basophil percentage of granulocytes;White blood cell count (basophil);Basophil percentage of white cells; CRC cis rs7312933 0.703 rs7957471 chr12:42545591 G/T cg11827402 chr12:42719852 PPHLN1;ZCRB1 0.63 8.85 0.44 5.33e-17 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CRC cis rs7666738 0.571 rs7683769 chr4:99091742 T/C cg05340658 chr4:99064831 C4orf37 0.49 7.17 0.37 5.06e-12 Colonoscopy-negative controls vs population controls; CRC cis rs35000415 0.873 rs62478615 chr7:128684316 G/C cg19972273 chr7:128594194 NA 0.68 6.15 0.32 2.28e-9 Systemic lupus erythematosus; CRC cis rs561341 1.000 rs4795668 chr17:30244554 G/A cg19193384 chr17:30244184 NA -0.59 -7.01 -0.36 1.33e-11 Hip circumference adjusted for BMI; CRC cis rs6570726 1.000 rs450076 chr6:145847655 G/T cg05347473 chr6:146136440 FBXO30 0.39 6.18 0.32 1.85e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs10504229 0.683 rs66893068 chr8:58144238 A/G cg24829409 chr8:58192753 C8orf71 -0.55 -8.04 -0.41 1.64e-14 Developmental language disorder (linguistic errors); CRC cis rs977987 0.843 rs10514396 chr16:75422903 T/C cg03315344 chr16:75512273 CHST6 0.52 8.85 0.44 5.66e-17 Dupuytren's disease; CRC cis rs728616 0.614 rs61859189 chr10:82089250 T/C cg05935833 chr10:81318306 SFTPA2 -0.48 -6.57 -0.34 1.95e-10 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs1348850 0.874 rs12996447 chr2:178283592 C/T cg02961200 chr2:178257176 LOC100130691;AGPS 0.56 8.29 0.42 2.9e-15 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs1801251 1.000 rs9653383 chr2:233670380 A/C cg25237894 chr2:233734115 C2orf82 -0.53 -8.48 -0.42 7.89e-16 Coronary artery disease; CRC cis rs66573146 1.000 rs55672215 chr4:6970529 T/C cg00086871 chr4:6988644 TBC1D14 0.98 8.14 0.41 8.47e-15 Granulocyte percentage of myeloid white cells; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg03545677 chr2:47403996 CALM2 0.42 5.98 0.31 5.88e-9 Intelligence (multi-trait analysis); CRC cis rs7666738 0.791 rs6840669 chr4:99016020 G/T cg17366294 chr4:99064904 C4orf37 0.44 7.35 0.38 1.55e-12 Colonoscopy-negative controls vs population controls; CRC cis rs35520189 0.592 rs12471839 chr2:113712489 G/C cg12858261 chr2:113808755 IL1F8 0.46 6.23 0.32 1.41e-9 Obstructive sleep apnea trait (apnea hypopnea index); CRC cis rs868943 0.714 rs13193683 chr6:116356235 A/T cg26893134 chr6:116381904 FRK 0.27 6.45 0.33 4.06e-10 Total cholesterol levels; CRC cis rs875971 0.862 rs1968126 chr7:66057004 A/G cg00343986 chr7:65444356 GUSB -0.45 -6.23 -0.32 1.45e-9 Aortic root size; CRC cis rs2839186 0.500 rs13049893 chr21:47707054 C/T cg00815214 chr21:47717953 NA -0.39 -6.38 -0.33 5.84e-10 Testicular germ cell tumor; CRC cis rs2576037 0.623 rs2571000 chr18:44580347 G/A cg07643061 chr18:44555308 TCEB3C;TCEB3CL;KATNAL2 0.35 5.65 0.3 3.47e-8 Personality dimensions; CRC cis rs7224685 0.501 rs781825 chr17:3966064 A/G cg10724054 chr17:3904396 NA -0.47 -7.93 -0.4 3.5e-14 Type 2 diabetes; CRC cis rs11677416 1.000 rs7570215 chr2:113527660 G/T cg06156847 chr2:113672199 IL1F7 -0.4 -6.03 -0.32 4.38e-9 Response to antipsychotic treatment in schizophrenia (working memory); CRC cis rs10504229 0.683 rs2088217 chr8:58113124 C/T cg24829409 chr8:58192753 C8orf71 -0.55 -7.9 -0.4 4.11e-14 Developmental language disorder (linguistic errors); CRC cis rs12220238 1.000 rs11000936 chr10:75992383 A/T cg19889307 chr10:75911429 ADK;AP3M1 0.56 5.73 0.3 2.25e-8 Soluble interleukin-2 receptor subunit alpha; CRC cis rs6502050 0.723 rs11650633 chr17:80083807 T/C cg19223190 chr17:80058835 NA -0.39 -6.17 -0.32 2.01e-9 Life satisfaction; CRC cis rs514406 0.861 rs6588443 chr1:53250650 G/A cg08859206 chr1:53392774 SCP2 0.44 6.75 0.35 6.58e-11 Monocyte count; CRC cis rs990171 0.955 rs10165460 chr2:103085631 C/T cg03938978 chr2:103052716 IL18RAP 0.47 5.93 0.31 7.82e-9 Lymphocyte counts; CRC cis rs7552404 0.731 rs17650138 chr1:76398887 C/T cg03433033 chr1:76189801 ACADM -0.68 -8.19 -0.41 5.77e-15 Blood metabolite levels;Acylcarnitine levels; CRC cis rs919433 0.783 rs787979 chr2:198242868 A/T cg10820045 chr2:198174542 NA 0.44 7.73 0.39 1.33e-13 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC cis rs7772486 0.817 rs9322047 chr6:146400394 G/A cg23711669 chr6:146136114 FBXO30 0.64 11.16 0.52 9.95e-25 Lobe attachment (rater-scored or self-reported); CRC trans rs875971 0.545 rs1638724 chr7:66040481 A/G cg02869306 chr7:64672164 INTS4L1 0.46 6.6 0.34 1.6e-10 Aortic root size; CRC cis rs7772486 0.754 rs6570718 chr6:146088443 T/G cg05347473 chr6:146136440 FBXO30 -0.38 -5.67 -0.3 3.17e-8 Lobe attachment (rater-scored or self-reported); CRC cis rs2115630 1.000 rs7183401 chr15:85371944 G/T cg11189052 chr15:85197271 WDR73 -0.55 -8.98 -0.44 2.11e-17 P wave terminal force; CRC cis rs7605827 0.930 rs6704723 chr2:15599895 A/G cg19274914 chr2:15703543 NA 0.4 6.04 0.32 4.18e-9 Educational attainment (years of education); CRC cis rs7224685 0.501 rs6502765 chr17:3901814 A/G cg05562828 chr17:3906858 NA 0.73 13.99 0.61 3.12e-35 Type 2 diabetes; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg00748821 chr4:83932227 LIN54 0.48 6.89 0.36 2.87e-11 Response to antipsychotic treatment; CRC cis rs651907 0.514 rs34301719 chr3:101417993 C/T cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.6 7.95 0.4 3e-14 Colorectal cancer; CRC cis rs853679 1.000 rs853685 chr6:28288785 C/T cg06470822 chr6:28175283 NA 0.64 6.55 0.34 2.24e-10 Depression; CRC cis rs11785693 0.862 rs11783719 chr8:4991311 G/T cg26367366 chr8:4980734 NA 0.83 9.87 0.48 2.67e-20 Neuroticism (multi-trait analysis);Neuroticism; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg00566492 chr22:39096679 JOSD1 -0.38 -6.02 -0.31 4.7e-9 Myopia (pathological); CRC trans rs2303319 0.504 rs62189053 chr2:162624324 G/A cg25193742 chr10:104614220 C10orf32 -0.76 -6.46 -0.34 3.66e-10 Cognitive function; CRC cis rs747650 0.504 rs6485715 chr11:46975125 C/T cg19486271 chr11:47235900 DDB2 0.43 6.61 0.34 1.54e-10 Acne (severe); CRC trans rs9467711 0.659 rs13220261 chr6:26499185 C/T cg06606381 chr12:133084897 FBRSL1 -1.07 -7.41 -0.38 1.09e-12 Autism spectrum disorder or schizophrenia; CRC cis rs7772486 0.875 rs11155452 chr6:146424631 C/T cg23711669 chr6:146136114 FBXO30 0.66 11.56 0.54 3.65e-26 Lobe attachment (rater-scored or self-reported); CRC cis rs6860806 0.661 rs6871350 chr5:131580220 A/G cg20512303 chr5:131592959 PDLIM4 0.34 6.33 0.33 8.21e-10 Breast cancer; CRC cis rs12477438 0.520 rs8179690 chr2:99795300 A/T cg14399236 chr2:99771627 LIPT1;TSGA10 -0.81 -14.45 -0.62 5.64e-37 Chronic sinus infection; CRC cis rs6662572 0.737 rs72690901 chr1:46378028 C/T cg03123370 chr1:45965343 CCDC163P;MMACHC 0.45 5.71 0.3 2.56e-8 Blood protein levels; CRC cis rs1862618 0.671 rs2591961 chr5:56238597 A/G cg18230493 chr5:56204884 C5orf35 0.58 8.84 0.44 5.7e-17 Initial pursuit acceleration; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg10335543 chr14:102829157 TECPR2;CINP 0.39 6.24 0.33 1.31e-9 Liver disease severity in Alagille syndrome; CRC cis rs6952808 0.698 rs11765639 chr7:1986738 G/A cg02951883 chr7:2050386 MAD1L1 -0.73 -10.78 -0.51 2.18e-23 Bipolar disorder and schizophrenia; CRC cis rs763014 0.966 rs4984904 chr16:680809 C/G cg02475695 chr16:616220 NHLRC4 0.44 7.15 0.37 5.54e-12 Height; CRC cis rs995000 0.931 rs1168098 chr1:63121294 G/A cg19896129 chr1:63156450 NA -0.41 -6.36 -0.33 6.93e-10 Triglyceride levels; CRC cis rs9858542 0.953 rs9811982 chr3:49624377 A/C cg03060546 chr3:49711283 APEH -0.47 -6.43 -0.33 4.44e-10 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs1448094 0.512 rs56082822 chr12:86255475 C/T cg00310523 chr12:86230176 RASSF9 0.34 5.75 0.3 2.08e-8 Major depressive disorder; CRC cis rs10504229 0.679 rs6995378 chr8:58113933 C/T cg02290350 chr8:58132656 NA -0.58 -8.24 -0.41 4.09e-15 Developmental language disorder (linguistic errors); CRC cis rs10540 1.000 rs35874808 chr11:506442 G/T cg21784768 chr11:537496 LRRC56 -0.7 -6.67 -0.35 1.07e-10 Body mass index; CRC trans rs9326248 1.000 rs664922 chr11:117070895 C/A cg18755114 chr2:209119030 IDH1 -0.41 -6.18 -0.32 1.9e-9 Blood protein levels; CRC trans rs853679 0.546 rs200948 chr6:27835272 T/C cg16898833 chr6:26189333 HIST1H4D 0.72 6.45 0.34 4.08e-10 Depression; CRC cis rs4819052 0.851 rs2838858 chr21:46681093 T/A cg02159808 chr21:46707872 POFUT2;LOC642852 0.51 6.76 0.35 6.47e-11 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs3858526 0.916 rs11039551 chr11:5930773 C/T cg13902645 chr11:5959945 NA -0.62 -8.67 -0.43 1.94e-16 DNA methylation (variation); CRC cis rs7580658 0.864 rs1566823 chr2:128018192 A/G cg09760422 chr2:128146352 NA -0.3 -5.91 -0.31 8.53e-9 Protein C levels; CRC cis rs7619833 0.593 rs7626742 chr3:27268398 G/T cg02860705 chr3:27208620 NA 0.36 5.68 0.3 2.98e-8 Breast cancer; CRC cis rs4481887 1.000 rs6681423 chr1:248482834 C/A cg13385794 chr1:248469461 NA 0.39 6.7 0.35 8.96e-11 Common traits (Other); CRC cis rs12024301 0.557 rs6663499 chr1:183640764 C/G cg11505048 chr1:183622726 RGL1;APOBEC4 0.78 6.99 0.36 1.52e-11 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs7945705 0.782 rs2742545 chr11:8884308 C/G cg14711859 chr11:8959438 ASCL3 0.39 6.67 0.34 1.11e-10 Hemoglobin concentration; CRC trans rs12517041 1.000 rs74322845 chr5:23293404 A/G ch.8.1293020R chr8:59333349 UBXN2B -0.55 -6.17 -0.32 2.05e-9 Calcium levels; CRC trans rs35110281 0.837 rs7279958 chr21:45016016 C/A cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.44 7.21 0.37 3.84e-12 Mean corpuscular volume; CRC cis rs929354 0.772 rs6971896 chr7:156978412 C/T cg16102536 chr7:156981717 UBE3C 0.4 6.77 0.35 5.77e-11 Body mass index; CRC cis rs2204008 0.659 rs4002655 chr12:38169881 T/G cg26384229 chr12:38710491 ALG10B 0.67 8.93 0.44 3.04e-17 Bladder cancer; CRC cis rs6500602 0.727 rs4786510 chr16:4571247 A/G cg14951292 chr16:4525986 HMOX2;NMRAL1 0.56 8.43 0.42 1.08e-15 Schizophrenia; CRC cis rs2760061 0.626 rs594916 chr1:228133544 C/A cg18477163 chr1:228402036 OBSCN -0.37 -6.05 -0.32 3.95e-9 Diastolic blood pressure; CRC trans rs8002861 0.664 rs9533686 chr13:44468494 A/G cg17145862 chr1:211918768 LPGAT1 0.61 10.17 0.49 2.66e-21 Leprosy; CRC trans rs2228479 0.867 rs35542367 chr16:89965825 G/C cg24644049 chr4:85504048 CDS1 0.75 6.82 0.35 4.42e-11 Skin colour saturation; CRC cis rs7617773 1.000 rs6442108 chr3:48192959 G/C cg11946769 chr3:48343235 NME6 -0.5 -6.73 -0.35 7.49e-11 Coronary artery disease; CRC cis rs2836974 0.931 rs2836972 chr21:40652142 G/A cg17971929 chr21:40555470 PSMG1 0.83 11.88 0.55 2.57e-27 Cognitive function; CRC cis rs6860806 0.507 rs273912 chr5:131661349 A/C cg12564285 chr5:131593104 PDLIM4 -0.45 -7.54 -0.38 4.5e-13 Breast cancer; CRC cis rs1577917 0.771 rs4351223 chr6:86237797 A/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A 0.66 8.73 0.43 1.33e-16 Response to antipsychotic treatment; CRC cis rs12188164 0.965 rs41282625 chr5:475626 C/G cg16322479 chr5:444228 EXOC3;C5orf55 0.5 8.14 0.41 8.01e-15 Cystic fibrosis severity; CRC cis rs703980 0.750 rs703974 chr10:80948593 A/G cg20744163 chr10:80999841 ZMIZ1 0.37 6.6 0.34 1.67e-10 Type 2 diabetes; CRC cis rs7772486 0.790 rs4280983 chr6:146280790 G/C cg23711669 chr6:146136114 FBXO30 -0.73 -12.69 -0.57 2.71e-30 Lobe attachment (rater-scored or self-reported); CRC cis rs4713118 0.662 rs9468275 chr6:28026136 G/T cg06470822 chr6:28175283 NA 0.95 13.58 0.6 1.14e-33 Parkinson's disease; CRC cis rs17155006 0.664 rs6974722 chr7:107738836 T/C cg05962710 chr7:107745446 LAMB4 -0.43 -7.53 -0.38 4.79e-13 Pneumococcal bacteremia; CRC trans rs4332037 0.539 rs55790766 chr7:2021248 C/T cg11693508 chr17:37793320 STARD3 0.66 7.81 0.4 7.66e-14 Bipolar disorder; CRC cis rs916888 0.687 rs199456 chr17:44797919 C/T cg15921436 chr17:44337874 NA 0.79 8.4 0.42 1.33e-15 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs13118159 0.550 rs2878607 chr4:1353310 G/C cg05025164 chr4:1340916 KIAA1530 0.6 8.59 0.43 3.65e-16 Longevity; CRC cis rs6951245 1.000 rs79683221 chr7:1096139 A/G cg21664854 chr7:1097933 C7orf50;GPR146 0.78 8.81 0.44 7.57e-17 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs9807989 0.507 rs6749014 chr2:103006448 C/T cg03938978 chr2:103052716 IL18RAP 0.59 10.18 0.49 2.53e-21 Asthma; CRC cis rs7618501 0.602 rs6780731 chr3:50017478 A/G cg24110177 chr3:50126178 RBM5 -0.47 -7.02 -0.36 1.27e-11 Intelligence (multi-trait analysis); CRC cis rs9372498 0.505 rs72956993 chr6:118949708 A/T cg24463073 chr6:118973353 C6orf204 0.48 6.22 0.32 1.49e-9 Diastolic blood pressure; CRC cis rs11711311 0.910 rs62265549 chr3:113396234 C/T cg15478005 chr3:113465772 ATP6V1A;NAA50 0.46 6.09 0.32 3.16e-9 IgG glycosylation; CRC cis rs1348850 0.958 rs12471741 chr2:178448196 A/G cg22681709 chr2:178499509 PDE11A -0.33 -6.23 -0.32 1.44e-9 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs55882075 0.722 rs10903245 chr5:179133608 T/C cg14593053 chr5:179126677 CANX 0.5 7.78 0.39 9.21e-14 Monocyte percentage of white cells; CRC cis rs9372498 0.572 rs62422230 chr6:118959436 T/C cg24463073 chr6:118973353 C6orf204 0.51 6.47 0.34 3.56e-10 Diastolic blood pressure; CRC trans rs2303319 0.504 rs12476631 chr2:162566936 A/G cg03774468 chr3:140950104 ACPL2 -0.67 -6.17 -0.32 2.06e-9 Cognitive function; CRC cis rs12630931 1.000 rs11713199 chr3:31975321 C/G cg21375017 chr3:31988082 OSBPL10 0.45 6.15 0.32 2.25e-9 Periodontal disease-related phenotypes; CRC cis rs4713118 0.621 rs4713134 chr6:28034121 T/C cg15786705 chr6:28176104 NA 0.72 9.36 0.46 1.33e-18 Parkinson's disease; CRC cis rs62045849 0.557 rs4782444 chr16:89183973 A/G cg08015503 chr16:89190385 ACSF3 -0.93 -7.33 -0.37 1.79e-12 Red blood cell count; CRC cis rs7020830 0.931 rs9775431 chr9:37130433 G/A cg14294708 chr9:37120828 ZCCHC7 1.06 20.76 0.75 8.99e-62 Schizophrenia; CRC trans rs9467711 1.000 rs6939978 chr6:26328462 G/C cg15845792 chr6:28175446 NA 0.66 6.42 0.33 4.88e-10 Autism spectrum disorder or schizophrenia; CRC cis rs3008870 0.920 rs1925413 chr1:67417101 T/C cg08660285 chr1:67390436 MIER1;WDR78 1.01 14.78 0.63 2.88e-38 Lymphocyte percentage of white cells; CRC cis rs7727544 1.000 rs10076701 chr5:131596419 A/G cg11843238 chr5:131593191 PDLIM4 0.38 7.44 0.38 8.63e-13 Blood metabolite levels; CRC cis rs11677416 1.000 rs1878320 chr2:113544467 T/C cg06156847 chr2:113672199 IL1F7 -0.4 -6.0 -0.31 5.18e-9 Response to antipsychotic treatment in schizophrenia (working memory); CRC cis rs4700695 0.719 rs27086 chr5:65453185 A/G cg21114390 chr5:65439923 SFRS12 -0.65 -8.64 -0.43 2.48e-16 Facial morphology (factor 19); CRC cis rs2282802 0.660 rs2436390 chr5:139586501 G/A cg26211634 chr5:139558579 C5orf32 -0.44 -7.68 -0.39 1.82e-13 Intelligence (multi-trait analysis); CRC cis rs826838 1.000 rs11183196 chr12:38685915 G/T cg26384229 chr12:38710491 ALG10B 0.77 10.8 0.51 1.84e-23 Heart rate; CRC cis rs7615952 0.673 rs35955861 chr3:125626201 T/C cg05084668 chr3:125655381 ALG1L -0.82 -9.99 -0.48 1.04e-20 Blood pressure (smoking interaction); CRC cis rs17780086 0.529 rs7406406 chr17:30220153 T/G cg00745463 chr17:30367425 LRRC37B -0.43 -5.72 -0.3 2.4e-8 Height; CRC cis rs9486715 0.867 rs4839828 chr6:96863326 G/A cg06623918 chr6:96969491 KIAA0776 1.02 20.27 0.75 7.46e-60 Headache; CRC cis rs12630931 0.928 rs13093442 chr3:31978144 T/C cg21375017 chr3:31988082 OSBPL10 0.43 5.87 0.31 1.05e-8 Periodontal disease-related phenotypes; CRC cis rs735396 0.770 rs1169314 chr12:121443116 A/G cg02403541 chr12:121454288 C12orf43 0.48 7.18 0.37 4.78e-12 N-glycan levels; CRC cis rs1865760 0.929 rs9358896 chr6:25943197 C/A cg16482183 chr6:26056742 HIST1H1C 0.53 7.52 0.38 5.13e-13 Height; CRC cis rs7129220 0.512 rs1867138 chr11:10228728 A/G cg23875677 chr11:10229755 SBF2 -0.59 -6.3 -0.33 9.74e-10 Systolic blood pressure;Diastolic blood pressure;Blood pressure; CRC cis rs4819052 0.851 rs2838832 chr21:46664904 A/G cg11663144 chr21:46675770 NA 0.83 13.69 0.6 4.43e-34 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC trans rs2303319 0.504 rs62189052 chr2:162623869 C/G cg03774468 chr3:140950104 ACPL2 -0.65 -6.07 -0.32 3.46e-9 Cognitive function; CRC trans rs6687430 0.512 rs34575776 chr1:10621061 A/G cg20645065 chr1:21836138 ALPL -0.4 -6.0 -0.31 5.25e-9 Hand grip strength; CRC trans rs11098499 1.000 rs35643470 chr4:120184948 T/C cg25214090 chr10:38739885 LOC399744 0.52 7.96 0.4 2.85e-14 Corneal astigmatism; CRC cis rs6815814 0.861 rs11936050 chr4:38789524 C/T cg06935464 chr4:38784597 TLR10 0.69 9.01 0.44 1.69e-17 Breast cancer; CRC cis rs2204008 0.749 rs4579984 chr12:38166266 A/G cg26384229 chr12:38710491 ALG10B 0.66 9.19 0.45 4.43e-18 Bladder cancer; CRC cis rs9916302 0.706 rs4794808 chr17:37531916 C/T cg15445000 chr17:37608096 MED1 -0.35 -6.23 -0.32 1.43e-9 Glomerular filtration rate (creatinine); CRC trans rs9914544 0.564 rs4334348 chr17:18787004 G/T cg21372672 chr17:16614065 CCDC144A -0.39 -6.1 -0.32 2.93e-9 Educational attainment (years of education); CRC cis rs13256369 1.000 rs1109619 chr8:8571616 G/T cg06636001 chr8:8085503 FLJ10661 0.45 5.78 0.3 1.73e-8 Obesity-related traits; CRC trans rs916888 0.821 rs199505 chr17:44859410 A/G cg07870213 chr5:140052090 DND1 -0.85 -10.09 -0.49 4.88e-21 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs1552244 1.000 rs6764068 chr3:10153842 A/G cg08888203 chr3:10149979 C3orf24 0.7 9.49 0.46 4.97e-19 Alzheimer's disease; CRC cis rs7542091 0.648 rs688464 chr1:209992539 C/T cg05527609 chr1:210001259 C1orf107 0.5 6.93 0.36 2.18e-11 Monobrow; CRC cis rs2952156 0.920 rs907090 chr17:37833632 T/C cg07936489 chr17:37558343 FBXL20 -0.4 -5.8 -0.3 1.53e-8 Asthma; CRC cis rs10504229 0.639 rs2318146 chr8:58114873 T/G cg05313129 chr8:58192883 C8orf71 -0.43 -6.0 -0.31 5.07e-9 Developmental language disorder (linguistic errors); CRC cis rs12999616 0.571 rs35263587 chr2:98506906 C/T cg26665480 chr2:98280029 ACTR1B 0.5 5.66 0.3 3.25e-8 Colorectal cancer; CRC cis rs1799949 1.000 rs9646412 chr17:41425893 A/T cg19454999 chr17:41278357 BRCA1;NBR2 0.51 7.82 0.4 7e-14 Menopause (age at onset); CRC cis rs875971 0.660 rs3764903 chr7:66098482 G/A cg00343986 chr7:65444356 GUSB -0.51 -7.62 -0.39 2.66e-13 Aortic root size; CRC cis rs801193 1.000 rs2707845 chr7:66198798 C/T cg00343986 chr7:65444356 GUSB 0.49 7.26 0.37 2.9e-12 Aortic root size; CRC cis rs854765 0.547 rs4584886 chr17:17896205 C/T cg16928487 chr17:17741425 SREBF1 -0.42 -7.48 -0.38 6.76e-13 Total body bone mineral density; CRC cis rs7584330 0.697 rs1979762 chr2:238436502 T/C cg16989719 chr2:238392110 NA -0.39 -7.81 -0.4 7.82e-14 Prostate cancer; CRC cis rs6502050 0.835 rs4789676 chr17:80123078 C/T cg19223190 chr17:80058835 NA 0.39 6.23 0.32 1.43e-9 Life satisfaction; CRC cis rs4965869 0.866 rs4965865 chr15:101975597 C/T cg12371147 chr15:101978424 PCSK6 -0.4 -5.7 -0.3 2.73e-8 Platelet-derived growth factor BB levels; CRC cis rs9826463 0.759 rs56161530 chr3:142332376 C/A cg20824294 chr3:142316082 PLS1 0.43 6.06 0.32 3.64e-9 QRS duration in Tripanosoma cruzi seropositivity; CRC cis rs6577655 0.517 rs6983560 chr8:135584553 C/T cg17885191 chr8:135476712 NA -0.5 -6.14 -0.32 2.35e-9 Visceral adipose tissue/subcutaneous adipose tissue ratio; CRC cis rs1862618 0.853 rs6885541 chr5:56110857 G/C cg20203395 chr5:56204925 C5orf35 -0.73 -8.59 -0.43 3.57e-16 Initial pursuit acceleration; CRC cis rs12701220 0.655 rs34696066 chr7:1140919 C/T cg00990874 chr7:1149470 C7orf50 -0.69 -9.14 -0.45 6.78e-18 Bronchopulmonary dysplasia; CRC cis rs2576037 0.526 rs2051292 chr18:44484372 C/G cg07643061 chr18:44555308 TCEB3C;TCEB3CL;KATNAL2 -0.37 -6.33 -0.33 8.02e-10 Personality dimensions; CRC cis rs17767294 0.612 rs9461425 chr6:27919688 G/A cg15845792 chr6:28175446 NA 0.78 8.05 0.41 1.56e-14 Parkinson's disease; CRC cis rs8177253 0.761 rs35332919 chr3:133519002 T/A cg12373951 chr3:133503437 NA 0.27 6.97 0.36 1.71e-11 Iron status biomarkers; CRC cis rs28386778 0.799 rs2665836 chr17:61898135 C/A cg22520471 chr17:61851767 DDX42;CCDC47 0.75 11.66 0.54 1.55e-26 Prudent dietary pattern; CRC cis rs7932354 0.528 rs2018527 chr11:47175809 A/G cg19486271 chr11:47235900 DDB2 0.44 6.47 0.34 3.48e-10 Bone mineral density (hip);Bone mineral density; CRC cis rs11997175 0.583 rs17780153 chr8:33789161 A/G cg04338863 chr8:33670619 NA 0.42 6.3 0.33 9.78e-10 Body mass index; CRC cis rs17666538 0.585 rs4735812 chr8:607766 C/G cg23958373 chr8:599963 NA 0.84 7.69 0.39 1.73e-13 IgG glycosylation; CRC cis rs9807841 0.545 rs4804514 chr19:10764203 G/T cg17710535 chr19:10819994 QTRT1 0.44 6.51 0.34 2.8e-10 Inflammatory skin disease; CRC cis rs9372498 0.536 rs9489407 chr6:118792337 A/T cg01339444 chr6:118972232 C6orf204 -0.54 -6.35 -0.33 7.34e-10 Diastolic blood pressure; CRC cis rs6424115 0.830 rs1130320 chr1:24200606 A/G cg15997130 chr1:24165203 NA 0.73 10.74 0.51 2.79e-23 Immature fraction of reticulocytes; CRC cis rs7945705 0.902 rs10743093 chr11:8869129 A/G cg14711859 chr11:8959438 ASCL3 -0.5 -8.07 -0.41 1.35e-14 Hemoglobin concentration; CRC cis rs9649213 0.593 rs3801263 chr7:97965016 A/G cg21770322 chr7:97807741 LMTK2 0.52 8.53 0.43 5.61e-16 Prostate cancer (SNP x SNP interaction); CRC cis rs9291683 0.588 rs3756236 chr4:10013463 T/A cg11266682 chr4:10021025 SLC2A9 0.54 11.57 0.54 3.2e-26 Bone mineral density; CRC cis rs35306767 0.903 rs12769002 chr10:927666 C/G cg20503657 chr10:835505 NA -1.18 -14.56 -0.63 2e-37 Eosinophil percentage of granulocytes; CRC cis rs11214589 0.905 rs10891539 chr11:113236492 G/C cg14159747 chr11:113255604 NA 0.56 11.19 0.53 7.28e-25 Neuroticism; CRC trans rs2303319 0.504 rs56371522 chr2:162491109 G/A cg22988483 chr14:93581567 ITPK1 -0.67 -6.04 -0.32 4.16e-9 Cognitive function; CRC cis rs2075371 0.796 rs1978504 chr7:134006933 C/T cg20476274 chr7:133979776 SLC35B4 -0.66 -10.84 -0.51 1.31e-23 Mean platelet volume; CRC cis rs1348850 0.914 rs4893957 chr2:178380409 A/G cg22681709 chr2:178499509 PDE11A -0.38 -6.9 -0.36 2.66e-11 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs10791323 0.511 rs4937837 chr11:133731134 T/C cg15485101 chr11:133734466 NA 0.47 7.87 0.4 5.02e-14 Childhood ear infection; CRC cis rs11146838 1 rs11146838 chr10:39149977 A/T cg13987078 chr10:38691799 CDC10L -0.39 -5.65 -0.3 3.53e-8 Breast cancer; CRC cis rs7131987 0.903 rs11050161 chr12:29420049 A/G cg09582351 chr12:29534625 ERGIC2 -0.33 -7.08 -0.36 9.04e-12 QT interval; CRC cis rs11608355 0.515 rs4766605 chr12:109895636 C/A cg05360138 chr12:110035743 NA 0.77 8.7 0.43 1.65e-16 Neuroticism; CRC cis rs875971 0.545 rs1065265 chr7:65841203 C/T cg18876405 chr7:65276391 NA 0.47 6.41 0.33 5.04e-10 Aortic root size; CRC cis rs6831352 0.918 rs2851247 chr4:100046091 C/G cg12011299 chr4:100065546 ADH4 -0.51 -9.16 -0.45 5.55e-18 Alcohol dependence; CRC cis rs870825 0.929 rs72689256 chr4:185590174 C/T cg04058563 chr4:185651563 MLF1IP 0.56 5.85 0.31 1.16e-8 Blood protein levels; CRC cis rs524281 0.861 rs10791858 chr11:65978396 A/G cg14036092 chr11:66035641 RAB1B -0.52 -6.11 -0.32 2.89e-9 Electroencephalogram traits; CRC cis rs6502050 0.799 rs7406257 chr17:80089340 G/A cg13198984 chr17:80129470 CCDC57 0.47 8.45 0.42 9.24e-16 Life satisfaction; CRC cis rs853679 0.517 rs9468292 chr6:28095355 G/A cg12273811 chr6:28175739 NA 0.73 9.36 0.46 1.34e-18 Depression; CRC cis rs7772486 0.594 rs6901864 chr6:146023050 C/A cg13319975 chr6:146136371 FBXO30 0.43 6.24 0.33 1.32e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs7824557 0.547 rs2409745 chr8:11076635 G/T cg27411982 chr8:10470053 RP1L1 0.36 5.63 0.3 3.91e-8 Retinal vascular caliber; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg21192376 chr14:53020168 GPR137C;TXNDC16 -0.42 -6.56 -0.34 2.12e-10 Myopia (pathological); CRC cis rs7918232 0.607 rs1755401 chr10:27405763 A/C cg14442939 chr10:27389572 ANKRD26 0.95 9.56 0.47 2.87e-19 Breast cancer; CRC cis rs3858526 0.834 rs7939099 chr11:5995792 G/A cg26762873 chr11:5879799 OR52E8 -0.41 -5.66 -0.3 3.24e-8 DNA methylation (variation); CRC cis rs3751196 0.808 rs17034625 chr12:104215308 A/G cg02344784 chr12:104178138 NT5DC3 0.71 7.54 0.38 4.58e-13 Sense of smell; CRC trans rs10207628 0.943 rs10207708 chr2:127852056 G/A cg22628694 chr19:58663362 ZNF329 0.56 6.01 0.31 5.05e-9 Psychosis and Alzheimer's disease; CRC cis rs17376456 0.597 rs1031423 chr5:93276883 A/G cg25358565 chr5:93447407 FAM172A -0.58 -7.75 -0.39 1.19e-13 Diabetic retinopathy; CRC trans rs16846053 0.786 rs115562071 chr2:162493241 C/T cg04269497 chr6:167369491 RNASET2 -0.74 -5.97 -0.31 6.27e-9 Blood osmolality (transformed sodium); CRC cis rs6860806 0.507 rs2631364 chr5:131706914 C/G cg04518342 chr5:131593106 PDLIM4 -0.44 -7.16 -0.37 5.43e-12 Breast cancer; CRC cis rs2011503 1.000 rs2965201 chr19:19478051 C/T cg11584989 chr19:19387371 SF4 -0.55 -6.34 -0.33 7.47e-10 Bipolar disorder; CRC cis rs875971 0.830 rs7799834 chr7:65880694 A/C cg11764359 chr7:65958608 NA 0.61 9.95 0.48 1.41e-20 Aortic root size; CRC cis rs3785574 0.962 rs7215915 chr17:61828385 C/T cg11494091 chr17:61959527 GH2 0.38 5.85 0.31 1.2e-8 Height; CRC cis rs8114671 0.527 rs2253484 chr20:33405263 A/T cg24642439 chr20:33292090 TP53INP2 -0.35 -5.65 -0.3 3.48e-8 Height; CRC cis rs34375054 0.526 rs4412800 chr12:125674742 C/T cg25124228 chr12:125621409 AACS 0.57 8.01 0.4 2.01e-14 Post bronchodilator FEV1/FVC ratio; CRC cis rs9611565 0.659 rs9611602 chr22:41908405 T/C cg17554472 chr22:41940697 POLR3H -0.52 -5.62 -0.3 4.11e-8 Vitiligo; CRC cis rs11702148 0.552 rs6517178 chr21:34888621 C/T cg14850771 chr21:34775459 IFNGR2 -0.39 -5.7 -0.3 2.63e-8 Mean corpuscular hemoglobin; CRC cis rs1799949 0.965 rs799916 chr17:41243190 G/T cg19454999 chr17:41278357 BRCA1;NBR2 -0.39 -6.06 -0.32 3.72e-9 Menopause (age at onset); CRC cis rs7827545 1.000 rs7823948 chr8:135566580 G/A cg13086574 chr8:135490821 ZFAT -0.38 -6.4 -0.33 5.48e-10 Hypertension (SNP x SNP interaction); CRC cis rs9435341 0.965 rs2335077 chr1:107573565 A/G cg09367891 chr1:107599246 PRMT6 0.6 9.2 0.45 4.15e-18 Facial morphology (factor 21, depth of nasal alae); CRC cis rs4481887 0.617 rs7511986 chr1:248527810 G/A cg00666640 chr1:248458726 OR2T12 0.34 6.48 0.34 3.3e-10 Common traits (Other); CRC cis rs10189230 0.967 rs11692482 chr2:222352405 C/T cg14652038 chr2:222343519 EPHA4 0.52 10.09 0.49 4.8e-21 Urate levels in lean individuals; CRC cis rs909674 0.541 rs5750816 chr22:39810379 A/G cg05872129 chr22:39784769 NA 0.6 11.52 0.54 5.19e-26 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; CRC cis rs755249 0.567 rs17264671 chr1:39818052 A/C cg18385671 chr1:39797026 MACF1 -0.41 -5.77 -0.3 1.81e-8 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs1065852 0.526 rs56234624 chr22:42388826 A/G cg00645731 chr22:42541494 CYP2D7P1 0.39 6.66 0.34 1.13e-10 Response to serotonin reuptake inhibitors in major depressive disorder (plasma drug and metabolite levels); CRC cis rs2836974 0.899 rs6517514 chr21:40527095 G/T cg11890956 chr21:40555474 PSMG1 1.1 21.14 0.76 3.07e-63 Cognitive function; CRC cis rs11098499 0.754 rs17595608 chr4:120250506 C/T cg24375607 chr4:120327624 NA 0.48 7.74 0.39 1.2e-13 Corneal astigmatism; CRC cis rs2408955 0.522 rs7139330 chr12:48483484 A/C cg00601486 chr12:48723148 H1FNT -0.34 -6.67 -0.35 1.09e-10 Glycated hemoglobin levels; CRC cis rs35306767 0.903 rs11253458 chr10:882843 T/C cg26597838 chr10:835615 NA 0.94 11.22 0.53 6.04e-25 Eosinophil percentage of granulocytes; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg13547250 chr16:30107791 YPEL3 0.37 6.16 0.32 2.17e-9 Liver disease severity in Alagille syndrome; CRC cis rs6502050 0.528 rs12942561 chr17:80116639 G/A cg02741985 chr17:80059408 CCDC57 0.43 7.18 0.37 4.68e-12 Life satisfaction; CRC cis rs6762 0.748 rs1130663 chr11:837582 G/A cg15787769 chr11:842744 TSPAN4;POLR2L -0.47 -6.69 -0.35 9.86e-11 Mean platelet volume; CRC cis rs67311347 1.000 rs1466237 chr3:40462026 C/G cg09455208 chr3:40491958 NA 0.45 9.18 0.45 4.89e-18 Renal cell carcinoma; CRC cis rs6942756 1.000 rs1473236 chr7:128880831 G/T cg02491457 chr7:128862824 NA -0.77 -10.61 -0.5 8.14e-23 White matter hyperintensity burden; CRC cis rs2204008 0.627 rs10878486 chr12:38148601 T/G cg13010199 chr12:38710504 ALG10B 0.46 5.82 0.31 1.39e-8 Bladder cancer; CRC cis rs9381040 0.655 rs2268194 chr6:41024447 T/C cg03644281 chr6:41068752 NFYA;LOC221442 -0.44 -6.33 -0.33 8.04e-10 Alzheimer's disease (late onset); CRC cis rs2991971 0.967 rs937291 chr1:45957039 G/T cg03123370 chr1:45965343 CCDC163P;MMACHC -0.39 -5.98 -0.31 5.76e-9 High light scatter reticulocyte count; CRC cis rs1552244 0.882 rs13099136 chr3:10031431 G/A cg16606324 chr3:10149918 C3orf24 0.61 7.94 0.4 3.22e-14 Alzheimer's disease; CRC cis rs2742417 1.000 rs2742452 chr3:45765708 C/T cg04837898 chr3:45731254 SACM1L -0.34 -5.63 -0.3 3.86e-8 Response to anti-depressant treatment in major depressive disorder; CRC cis rs992157 0.835 rs2271543 chr2:219142491 C/T cg00012203 chr2:219082015 ARPC2 -0.47 -7.14 -0.37 6.05e-12 Colorectal cancer; CRC trans rs4689592 0.546 rs2359012 chr4:7066053 A/C cg07817883 chr1:32538562 TMEM39B -0.6 -7.55 -0.38 4.32e-13 Monocyte percentage of white cells; CRC cis rs7127900 0.614 rs11564708 chr11:2206326 C/G cg10838469 chr11:2211741 NA 0.47 6.69 0.35 9.6e-11 Prostate cancer;Prostate cancer (SNP x SNP interaction);Prostate cancer (early onset); CRC cis rs6502050 0.835 rs4789672 chr17:80126603 T/C cg09264619 chr17:80180166 NA -0.35 -5.84 -0.31 1.27e-8 Life satisfaction; CRC cis rs96067 0.711 rs272827 chr1:36627191 C/T cg24686825 chr1:36642396 MAP7D1 0.51 6.77 0.35 5.91e-11 Corneal structure; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg17150678 chr19:49617435 LIN7B 0.44 6.29 0.33 1.03e-9 Response to antipsychotic treatment; CRC cis rs35110281 0.807 rs9984002 chr21:45061501 T/C cg04455712 chr21:45112962 RRP1B 0.41 8.12 0.41 9.76e-15 Mean corpuscular volume; CRC cis rs763014 0.966 rs4984677 chr16:671682 A/G cg00802000 chr16:706648 WDR90 -0.44 -6.33 -0.33 7.87e-10 Height; CRC cis rs9733 0.519 rs2184833 chr1:150675483 C/T cg18016565 chr1:150552671 MCL1 0.47 6.78 0.35 5.49e-11 Tonsillectomy; CRC cis rs7959452 0.503 rs7300266 chr12:69654187 A/G cg14784868 chr12:69753453 YEATS4 0.73 12.07 0.55 5.24e-28 Blood protein levels; CRC cis rs4481887 0.861 rs4309013 chr1:248480768 C/T cg13385794 chr1:248469461 NA 0.38 6.67 0.35 1.09e-10 Common traits (Other); CRC cis rs926938 0.520 rs2007231 chr1:115266306 C/T cg12756093 chr1:115239321 AMPD1 -0.64 -8.87 -0.44 4.71e-17 Autism; CRC cis rs10924970 0.649 rs4659763 chr1:235447779 T/C cg09010748 chr1:235293032 TOMM20 -0.42 -5.87 -0.31 1.04e-8 Asthma; CRC cis rs2228479 0.867 rs11642451 chr16:89958127 T/C cg06558623 chr16:89946397 TCF25 1.06 10.8 0.51 1.79e-23 Skin colour saturation; CRC cis rs6951245 0.529 rs10262070 chr7:1141738 C/T cg26224354 chr7:1096374 C7orf50;GPR146 -0.59 -7.96 -0.4 2.81e-14 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs28386778 0.897 rs2137144 chr17:61805607 G/A cg06601766 chr17:61851465 DDX42;CCDC47 0.44 5.99 0.31 5.35e-9 Prudent dietary pattern; CRC cis rs4073582 0.595 rs3016319 chr11:65981846 C/T cg14036092 chr11:66035641 RAB1B 0.54 8.66 0.43 2.22e-16 Gout; CRC cis rs3820068 0.603 rs16851884 chr1:15961871 A/G cg24675056 chr1:15929824 NA 0.51 7.06 0.36 9.73e-12 Systolic blood pressure; CRC cis rs9916302 0.595 rs4795371 chr17:37636695 T/G cg03013999 chr17:37608204 MED1 0.43 6.6 0.34 1.68e-10 Glomerular filtration rate (creatinine); CRC cis rs72945132 0.882 rs72945168 chr11:70131471 G/C cg00319359 chr11:70116639 PPFIA1 0.67 7.4 0.38 1.13e-12 Coronary artery disease; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg13884470 chr9:86595151 HNRNPK;RMI1 -0.4 -6.34 -0.33 7.48e-10 Myopia (pathological); CRC cis rs4665809 0.531 rs3892649 chr2:26457267 T/G cg08067268 chr2:26466485 HADHB;HADHA 0.66 8.38 0.42 1.54e-15 Gut microbiome composition (summer); CRC cis rs7474896 0.559 rs2753880 chr10:38173338 G/A cg25427524 chr10:38739819 LOC399744 0.66 8.11 0.41 1.03e-14 Obesity (extreme); CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg03837750 chr1:74664160 LRRIQ3;TNNI3K;FPGT -0.56 -6.75 -0.35 6.72e-11 Diisocyanate-induced asthma; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg26117622 chr2:242042254 MTERFD2 0.4 6.18 0.32 1.9e-9 Liver disease severity in Alagille syndrome; CRC cis rs2243480 1.000 rs68189316 chr7:65409169 C/G cg18252515 chr7:66147081 NA -1.06 -12.44 -0.57 2.13e-29 Diabetic kidney disease; CRC cis rs4969178 0.965 rs2292642 chr17:76395430 C/T cg05887092 chr17:76393375 PGS1 0.56 10.13 0.49 3.7e-21 HDL cholesterol levels; CRC cis rs7666738 0.606 rs4699606 chr4:99095074 A/C cg05340658 chr4:99064831 C4orf37 -0.51 -7.02 -0.36 1.26e-11 Colonoscopy-negative controls vs population controls; CRC cis rs12900413 0.687 rs6496599 chr15:90314582 C/T cg24249390 chr15:90295951 MESP1 -0.59 -9.61 -0.47 1.93e-19 Coronary artery aneurysm in Kawasaki disease; CRC cis rs12913538 1.000 rs4265758 chr15:62896297 T/G cg09983546 chr15:62884068 NA 0.61 9.68 0.47 1.12e-19 Sleep depth; CRC cis rs12760731 0.720 rs3791023 chr1:178398092 A/C cg00404053 chr1:178313656 RASAL2 0.98 10.15 0.49 3.04e-21 Obesity-related traits; CRC cis rs9372498 0.505 rs17427284 chr6:118991953 A/T cg18833306 chr6:118973337 C6orf204 0.46 5.67 0.3 3.14e-8 Diastolic blood pressure; CRC cis rs2180341 0.618 rs12529077 chr6:127634244 G/T cg27446573 chr6:127587934 RNF146 0.63 9.2 0.45 4.09e-18 Breast cancer; CRC cis rs1448094 0.512 rs60986162 chr12:86247054 T/G cg00310523 chr12:86230176 RASSF9 0.35 5.93 0.31 7.63e-9 Major depressive disorder; CRC cis rs62229266 0.804 rs2835231 chr21:37390598 C/T cg08632701 chr21:37451849 NA -0.41 -6.36 -0.33 6.77e-10 Mitral valve prolapse; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg09858208 chr3:50283852 GNAI2 0.43 6.01 0.31 5.05e-9 Response to antipsychotic treatment; CRC cis rs4713118 0.869 rs6456802 chr6:27698355 A/G cg26587870 chr6:27730563 NA -0.43 -6.72 -0.35 8.04e-11 Parkinson's disease; CRC cis rs7666738 0.830 rs13112131 chr4:98976784 G/A cg05340658 chr4:99064831 C4orf37 0.6 9.35 0.46 1.41e-18 Colonoscopy-negative controls vs population controls; CRC cis rs7493 0.950 rs17880101 chr7:95031457 A/T cg20119798 chr7:94954144 PON1 -0.5 -6.28 -0.33 1.1e-9 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs6502050 0.835 rs4789675 chr17:80123144 G/A cg19223190 chr17:80058835 NA 0.39 6.23 0.32 1.43e-9 Life satisfaction; CRC cis rs9359856 0.510 rs3736984 chr6:90408589 C/T cg13799429 chr6:90582589 CASP8AP2 0.78 10.49 0.5 2.11e-22 Bipolar disorder; CRC cis rs172166 0.637 rs1225595 chr6:28151340 A/T cg10876282 chr6:28092338 ZSCAN16 0.48 6.6 0.34 1.68e-10 Cardiac Troponin-T levels; CRC cis rs7267979 0.873 rs7453 chr20:25207074 A/G cg24626310 chr20:25276739 ABHD12;PYGB 0.32 5.69 0.3 2.78e-8 Liver enzyme levels (alkaline phosphatase); CRC cis rs990171 1.000 rs7561487 chr2:103077894 A/G cg03938978 chr2:103052716 IL18RAP 0.46 5.89 0.31 9.34e-9 Lymphocyte counts; CRC cis rs875971 0.862 rs949930 chr7:65766822 C/G cg18252515 chr7:66147081 NA 0.39 5.66 0.3 3.24e-8 Aortic root size; CRC cis rs281302 0.621 rs392572 chr15:47743625 A/G cg13159054 chr15:47721715 NA -0.44 -6.49 -0.34 3.1e-10 Educational attainment (years of education);Cognitive ability (multi-trait analysis); CRC cis rs12347191 0.500 rs973473 chr9:100620730 T/G cg13688889 chr9:100608707 NA -0.47 -5.92 -0.31 8.27e-9 Orofacial clefts; CRC trans rs12310956 0.532 rs11052952 chr12:33988048 G/A cg26384229 chr12:38710491 ALG10B 0.51 6.43 0.33 4.44e-10 Morning vs. evening chronotype; CRC trans rs10838798 0.504 rs7479393 chr11:48295303 G/C cg21153622 chr11:89784906 NA -0.49 -8.02 -0.4 1.88e-14 Height; CRC cis rs6951245 1.000 rs77083167 chr7:1071823 C/T cg26224354 chr7:1096374 C7orf50;GPR146 -0.88 -11.08 -0.52 1.89e-24 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs5758659 0.714 rs6002626 chr22:42517989 C/G cg25452165 chr22:42524984 CYP2D6 -0.41 -5.77 -0.3 1.84e-8 Cognitive function; CRC trans rs11098499 0.863 rs7695620 chr4:120452776 G/A cg25214090 chr10:38739885 LOC399744 0.65 10.07 0.49 5.96e-21 Corneal astigmatism; CRC cis rs7635838 0.687 rs7625495 chr3:11377918 G/T cg00170343 chr3:11313890 ATG7 0.46 7.08 0.36 8.84e-12 HDL cholesterol; CRC cis rs11098499 0.863 rs2306457 chr4:120472839 T/A cg09307838 chr4:120376055 NA 0.67 10.11 0.49 4.35e-21 Corneal astigmatism; CRC cis rs6604026 0.848 rs2893226 chr1:93288437 G/A cg22128645 chr1:93425802 FAM69A -0.4 -5.93 -0.31 7.66e-9 Multiple sclerosis; CRC cis rs1881797 1.000 rs68059491 chr1:247683070 C/T cg11166453 chr1:247681781 NA 0.45 7.04 0.36 1.1e-11 Acute lymphoblastic leukemia (childhood); CRC cis rs10504229 0.683 rs16921831 chr8:58111142 G/A cg02725872 chr8:58115012 NA -0.66 -11.64 -0.54 1.83e-26 Developmental language disorder (linguistic errors); CRC cis rs2692947 0.683 rs1813381 chr2:96422939 C/T cg23100626 chr2:96804247 ASTL -0.29 -7.15 -0.37 5.53e-12 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; CRC cis rs45509595 0.841 rs9368531 chr6:27781872 G/C cg15845792 chr6:28175446 NA 0.72 6.15 0.32 2.24e-9 Breast cancer; CRC cis rs727505 0.564 rs68107250 chr7:124870200 G/A cg23710748 chr7:124431027 NA -0.62 -10.29 -0.49 1.04e-21 Lewy body disease; CRC cis rs6456156 0.792 rs10946212 chr6:167515947 C/G cg07741184 chr6:167504864 NA 0.49 8.49 0.42 7.33e-16 Primary biliary cholangitis; CRC cis rs875971 0.638 rs801205 chr7:66022144 C/A cg11764359 chr7:65958608 NA -0.55 -8.6 -0.43 3.21e-16 Aortic root size; CRC trans rs2727020 0.729 rs7924782 chr11:49267249 A/G cg21153622 chr11:89784906 NA -0.44 -6.93 -0.36 2.28e-11 Coronary artery disease; CRC cis rs3741404 0.620 rs2236648 chr11:63964657 C/T cg18225595 chr11:63971243 STIP1 0.54 8.81 0.44 7.41e-17 Platelet count; CRC cis rs1865760 0.929 rs1436307 chr6:25939723 C/T cg17691542 chr6:26056736 HIST1H1C 0.54 7.75 0.39 1.14e-13 Height; CRC cis rs10221833 0.602 rs355893 chr2:165635147 A/G cg03182029 chr2:165697222 COBLL1 0.52 6.09 0.32 3.22e-9 Response to statin therapy; CRC cis rs7917772 0.536 rs12357172 chr10:104388549 C/T cg11453585 chr10:104263688 ACTR1A;SUFU 0.9 13.94 0.61 4.84e-35 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC cis rs7617773 0.851 rs7647817 chr3:48236507 G/A cg11946769 chr3:48343235 NME6 0.71 9.58 0.47 2.51e-19 Coronary artery disease; CRC trans rs2470578 0.716 rs2733514 chr3:17323931 A/G cg20994686 chr17:71306668 CDC42EP4 -0.4 -6.0 -0.31 5.11e-9 Schizophrenia; CRC cis rs2204008 0.840 rs7957966 chr12:37953629 A/G cg26384229 chr12:38710491 ALG10B -0.64 -9.64 -0.47 1.52e-19 Bladder cancer; CRC cis rs5750830 0.621 rs5757665 chr22:39821641 A/G cg11247378 chr22:39784982 NA -0.41 -7.4 -0.38 1.11e-12 Intelligence (multi-trait analysis); CRC cis rs1799949 1.000 rs12952790 chr17:41299607 A/G cg23758822 chr17:41437982 NA 0.79 13.45 0.6 3.6e-33 Menopause (age at onset); CRC cis rs10992471 0.756 rs7043152 chr9:95138499 A/G cg14631576 chr9:95140430 CENPP -0.4 -7.44 -0.38 8.78e-13 Visceral adipose tissue/subcutaneous adipose tissue ratio; CRC cis rs7618915 0.547 rs3755806 chr3:52643685 C/T cg11645453 chr3:52864694 ITIH4 -0.34 -5.95 -0.31 6.72e-9 Bipolar disorder; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg03993376 chr5:172386357 LOC100268168;RPL26L1 0.42 6.19 0.32 1.74e-9 Response to antipsychotic treatment; CRC cis rs67311347 1.000 rs72861689 chr3:40435890 A/G cg24209194 chr3:40518798 ZNF619 0.4 5.9 0.31 9.03e-9 Renal cell carcinoma; CRC trans rs35110281 0.667 rs4819291 chr21:45123139 G/A cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.42 6.69 0.35 9.85e-11 Mean corpuscular volume; CRC cis rs4481887 1.000 rs4244178 chr1:248468441 A/G cg13385794 chr1:248469461 NA 0.37 6.42 0.33 4.78e-10 Common traits (Other); CRC cis rs7224685 0.871 rs8081968 chr17:3984117 C/T cg11204139 chr17:3907470 NA 0.54 8.71 0.43 1.51e-16 Type 2 diabetes; CRC cis rs10242455 0.702 rs6956305 chr7:99241310 A/G cg18809830 chr7:99032528 PTCD1 -1.04 -7.34 -0.38 1.68e-12 Blood metabolite levels; CRC trans rs7485210 0.673 rs78606016 chr12:131632805 T/A cg23037403 chr5:178368183 ZNF454 -0.46 -5.99 -0.31 5.5e-9 Response to serotonin reuptake inhibitors in major depressive disorder; CRC trans rs6703335 0.870 rs10803142 chr1:243598234 A/G cg06155606 chr11:6704862 MRPL17 0.41 5.97 0.31 6.04e-9 Schizophrenia;Schizophrenia, schizoaffective disorder or bipolar disorder; CRC cis rs4665809 1.000 rs11126375 chr2:26344787 G/A cg22920501 chr2:26401640 FAM59B -0.52 -7.15 -0.37 5.68e-12 Gut microbiome composition (summer); CRC cis rs910316 1.000 rs7142235 chr14:75559963 T/C cg03030879 chr14:75389066 RPS6KL1 -0.46 -7.24 -0.37 3.14e-12 Height; CRC cis rs2481665 0.772 rs6668421 chr1:62536619 C/G cg18591186 chr1:62594603 INADL -0.58 -7.83 -0.4 6.8e-14 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs9341808 0.667 rs806783 chr6:80942943 A/C cg08355045 chr6:80787529 NA -0.36 -5.95 -0.31 6.71e-9 Sitting height ratio; CRC cis rs4713118 0.527 rs9461433 chr6:28095172 C/T cg18032046 chr6:28092343 ZSCAN16 -0.52 -6.08 -0.32 3.3e-9 Parkinson's disease; CRC cis rs1152591 0.524 rs1255990 chr14:64661523 A/G cg21174375 chr14:64681225 SYNE2 -0.4 -6.42 -0.33 4.84e-10 Atrial fibrillation; CRC cis rs6500395 1.000 rs7194570 chr16:48672986 A/G cg04672837 chr16:48644449 N4BP1 -0.44 -6.44 -0.33 4.33e-10 Response to tocilizumab in rheumatoid arthritis; CRC cis rs35306767 0.807 rs34982663 chr10:852521 C/G cg20503657 chr10:835505 NA 1.26 14.76 0.63 3.35e-38 Eosinophil percentage of granulocytes; CRC cis rs11608355 0.545 rs7139106 chr12:109908640 G/A cg05360138 chr12:110035743 NA 0.78 8.75 0.43 1.15e-16 Neuroticism; CRC cis rs6540559 1.000 rs7522250 chr1:209962539 T/C cg23283495 chr1:209979779 IRF6 0.45 6.91 0.36 2.46e-11 Cleft lip with or without cleft palate; CRC cis rs10504073 0.565 rs35282337 chr8:49920994 G/A cg00325661 chr8:49890786 NA 0.62 11.23 0.53 5.31e-25 Blood metabolite ratios; CRC cis rs2762353 0.595 rs13194155 chr6:25755508 C/T cg15691649 chr6:25882328 NA 0.48 6.17 0.32 1.99e-9 Blood metabolite levels; CRC cis rs11098499 0.604 rs34278750 chr4:120571136 G/A cg24375607 chr4:120327624 NA 0.51 7.62 0.39 2.76e-13 Corneal astigmatism; CRC cis rs853679 0.517 rs9468286 chr6:28079428 C/T cg15845792 chr6:28175446 NA 1.0 13.1 0.59 7.81e-32 Depression; CRC cis rs3768617 0.510 rs10911239 chr1:183062450 T/C ch.1.3577855R chr1:183094577 LAMC1 0.86 15.19 0.64 7.31e-40 Fuchs's corneal dystrophy; CRC cis rs7737355 0.773 rs4706027 chr5:130932972 T/C cg25547332 chr5:131281432 NA 0.37 5.76 0.3 1.98e-8 Life satisfaction; CRC cis rs6565180 0.926 rs4788413 chr16:30410445 C/T cg01392867 chr16:30410429 ZNF48 0.38 5.98 0.31 5.88e-9 Tonsillectomy; CRC cis rs4268898 0.662 rs72795832 chr2:24441855 C/A cg06627628 chr2:24431161 ITSN2 -0.84 -11.67 -0.54 1.49e-26 Asthma; CRC trans rs8108034 1.000 rs39587 chr19:39806997 C/T cg19628164 chr3:143689916 C3orf58 -0.59 -6.45 -0.34 3.9e-10 Lung adenocarcinoma; CRC cis rs4689388 0.816 rs13147655 chr4:6293474 A/G cg14416269 chr4:6271139 WFS1 0.4 6.65 0.34 1.19e-10 Type 2 diabetes and other traits;Type 2 diabetes; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg16102016 chr17:8126456 C17orf44 0.43 5.97 0.31 6.1e-9 Anxiety disorder; CRC cis rs34779708 0.897 rs9787566 chr10:35279455 T/A cg03585969 chr10:35415529 CREM 0.66 8.82 0.44 6.68e-17 Inflammatory bowel disease;Crohn's disease; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg25184507 chr17:7760147 CYB5D1;LSMD1 0.55 7.39 0.38 1.2e-12 Thyroid stimulating hormone; CRC cis rs911555 0.755 rs6575988 chr14:103900827 G/T cg12935359 chr14:103987150 CKB 0.54 8.97 0.44 2.36e-17 Intelligence (multi-trait analysis); CRC cis rs9309711 0.736 rs9678647 chr2:3497036 A/G cg10845886 chr2:3471009 TTC15 0.57 8.86 0.44 5.07e-17 Neurofibrillary tangles; CRC cis rs561341 1.000 rs550923 chr17:30327013 G/C cg12193833 chr17:30244370 NA -0.76 -8.87 -0.44 4.62e-17 Hip circumference adjusted for BMI; CRC trans rs1814175 0.791 rs1722011 chr11:49899340 G/C cg21153622 chr11:89784906 NA -0.38 -6.0 -0.31 5.28e-9 Height; CRC cis rs919433 0.783 rs788007 chr2:198233676 T/G cg10820045 chr2:198174542 NA 0.45 7.89 0.4 4.58e-14 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC cis rs4563143 0.675 rs73029042 chr19:29267979 A/T cg12667521 chr19:29218732 NA 0.49 7.49 0.38 6.26e-13 Methadone dose in opioid dependence; CRC cis rs1552244 0.832 rs115415687 chr3:10195704 C/T cg08888203 chr3:10149979 C3orf24 0.65 7.55 0.38 4.33e-13 Alzheimer's disease; CRC cis rs13108904 0.967 rs900027 chr4:1279360 G/A cg21620606 chr4:1342894 KIAA1530 0.36 5.97 0.31 6.06e-9 Obesity-related traits; CRC cis rs6951245 0.872 rs11768486 chr7:1101290 C/A cg18402987 chr7:1209562 NA 0.67 7.17 0.37 5.02e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs2549003 0.966 rs839 chr5:131819126 C/T cg02551604 chr5:131831745 NA -0.54 -8.34 -0.42 2e-15 Asthma (sex interaction); CRC cis rs4808199 1.000 rs12977524 chr19:19568244 A/G cg03709012 chr19:19516395 GATAD2A 1.02 12.33 0.56 5.56e-29 Nonalcoholic fatty liver disease; CRC cis rs9467711 0.651 rs35778245 chr6:25944803 G/A cg08501292 chr6:25962987 TRIM38 1.11 10.79 0.51 1.97e-23 Autism spectrum disorder or schizophrenia; CRC cis rs7223966 1.000 rs8070650 chr17:61744040 A/G cg23090583 chr17:61904693 PSMC5;FTSJ3 0.48 6.08 0.32 3.33e-9 Hip circumference adjusted for BMI;Body mass index; CRC cis rs1707322 0.686 rs2230658 chr1:46078854 A/G cg06784218 chr1:46089804 CCDC17 -0.66 -12.18 -0.56 1.94e-28 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs2204008 0.660 rs2874343 chr12:38239096 C/T cg26384229 chr12:38710491 ALG10B 0.7 9.31 0.46 1.88e-18 Bladder cancer; CRC cis rs1712517 0.771 rs11191676 chr10:105155066 C/A cg05636881 chr10:105038444 INA 0.48 8.18 0.41 6.1e-15 Migraine; CRC cis rs6717918 0.672 rs2853359 chr2:233118874 C/G ch.2.233013039R chr2:233304795 NA 0.5 6.29 0.33 1.02e-9 Height; CRC cis rs4478858 0.718 rs10914329 chr1:31688441 T/A cg00250761 chr1:31883323 NA 0.31 5.82 0.31 1.42e-8 Alcohol dependence; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg26483432 chr1:149815043 HIST2H2AA3;HIST2H2AA4 0.5 7.64 0.39 2.36e-13 Liver disease severity in Alagille syndrome; CRC cis rs736801 0.780 rs11951091 chr5:131786595 G/A cg07395648 chr5:131743802 NA -0.39 -5.69 -0.3 2.75e-8 Breast cancer;Mosquito bite size; CRC trans rs2797160 1.000 rs1777222 chr6:126021030 C/T cg05039488 chr6:79577232 IRAK1BP1 0.51 7.6 0.39 3.13e-13 Endometrial cancer; CRC cis rs13082711 0.640 rs66941564 chr3:27259702 C/A cg02860705 chr3:27208620 NA 0.69 9.73 0.47 7.59e-20 Systolic blood pressure;Diastolic blood pressure;Blood pressure; CRC cis rs1552244 0.810 rs6809572 chr3:10100145 G/A cg10729496 chr3:10149963 C3orf24 0.55 7.26 0.37 2.73e-12 Alzheimer's disease; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg09535168 chr19:19431582 KIAA0892;SF4 0.45 6.35 0.33 7.2e-10 Response to antipsychotic treatment; CRC cis rs2408955 0.522 rs10875721 chr12:48413593 A/G cg00601486 chr12:48723148 H1FNT -0.33 -6.31 -0.33 9.26e-10 Glycated hemoglobin levels; CRC cis rs8141529 0.732 rs5762815 chr22:29205076 A/G cg02153584 chr22:29168773 CCDC117 0.54 8.11 0.41 1.02e-14 Lymphocyte counts; CRC cis rs1568889 1.000 rs35697240 chr11:28287342 G/C cg06544937 chr11:28130018 METT5D1;KIF18A 0.79 10.91 0.52 7.06e-24 Bipolar disorder; CRC cis rs1552244 0.882 rs67631672 chr3:10004768 G/A cg13047869 chr3:10149882 C3orf24 0.53 7.24 0.37 3.11e-12 Alzheimer's disease; CRC cis rs9322193 0.923 rs12174035 chr6:150084447 A/T cg04369109 chr6:150039330 LATS1 -0.44 -6.17 -0.32 1.95e-9 Lung cancer; CRC cis rs13191362 1.000 rs13218900 chr6:163081638 T/C cg21926612 chr6:163149169 PACRG;PARK2 0.97 12.62 0.57 4.78e-30 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs12586317 0.547 rs116499019 chr14:35441931 T/C cg05294307 chr14:35346193 BAZ1A -0.71 -7.72 -0.39 1.41e-13 Psoriasis; CRC cis rs9388451 0.874 rs13209968 chr6:126089285 G/C cg10911889 chr6:126070802 HEY2 0.38 5.76 0.3 1.91e-8 Brugada syndrome; CRC cis rs9486715 0.867 rs6568428 chr6:96903604 A/G cg06623918 chr6:96969491 KIAA0776 1.01 20.07 0.74 4.5e-59 Headache; CRC cis rs9522267 0.535 rs7329118 chr13:112232693 C/T cg10483660 chr13:112241077 NA -0.47 -8.67 -0.43 1.97e-16 Hepatitis; CRC trans rs41997 0.785 rs2110215 chr7:118071216 C/T cg08498830 chr11:832797 CD151 -0.61 -6.23 -0.32 1.39e-9 Response to platinum-based chemotherapy in non-small-cell lung cancer; CRC cis rs3768617 0.510 rs1886501 chr1:183095234 A/G ch.1.3577855R chr1:183094577 LAMC1 0.89 15.86 0.66 1.84e-42 Fuchs's corneal dystrophy; CRC cis rs2072499 0.750 rs909269 chr1:156192028 C/T cg25208724 chr1:156163844 SLC25A44 0.99 15.25 0.64 4.17e-40 Testicular germ cell tumor; CRC cis rs916888 0.738 rs199515 chr17:44856641 C/G cg17911788 chr17:44343683 NA 0.57 7.09 0.36 8.47e-12 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs8073060 0.519 rs8065286 chr17:33864479 A/G cg01737554 chr17:33866071 SLFN12L -0.37 -6.23 -0.32 1.42e-9 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; CRC cis rs9818758 0.607 rs12185979 chr3:49651970 C/G cg00383909 chr3:49044727 WDR6 1.37 10.78 0.51 2.1e-23 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; CRC cis rs9910055 0.747 rs2905981 chr17:42238625 C/T cg13607699 chr17:42295918 UBTF 0.48 6.5 0.34 2.92e-10 Total body bone mineral density; CRC cis rs9462027 0.628 rs2814971 chr6:34714209 A/T cg07306190 chr6:34760872 UHRF1BP1 0.35 6.13 0.32 2.46e-9 Systemic lupus erythematosus; CRC cis rs6456156 0.774 rs9347175 chr6:167527644 A/T cg07513332 chr6:167530253 CCR6 -0.44 -8.21 -0.41 5.06e-15 Primary biliary cholangitis; CRC cis rs2180341 0.782 rs6912552 chr6:127722946 C/G cg24812749 chr6:127587940 RNF146 -0.66 -9.08 -0.45 1.06e-17 Breast cancer; CRC cis rs370915 0.542 rs13124558 chr4:187794175 T/C cg12892747 chr4:187813459 NA -0.56 -8.06 -0.41 1.4e-14 Gout; CRC cis rs910187 0.678 rs7352690 chr20:45815352 C/G cg27589058 chr20:45804311 EYA2 -0.42 -8.2 -0.41 5.38e-15 Migraine; CRC cis rs3096299 0.685 rs8050512 chr16:89552320 C/G cg02187348 chr16:89574699 SPG7 0.4 5.96 0.31 6.44e-9 Multiple myeloma (IgH translocation); CRC cis rs6840360 0.593 rs1877185 chr4:152690348 C/T cg22705602 chr4:152727874 NA -0.35 -6.03 -0.32 4.47e-9 Intelligence (multi-trait analysis); CRC trans rs629535 0.862 rs598548 chr8:70032438 C/T cg21567404 chr3:27674614 NA 0.95 16.08 0.66 2.35e-43 Dupuytren's disease; CRC cis rs977987 0.645 rs34904236 chr16:75498253 G/T cg03315344 chr16:75512273 CHST6 0.58 9.77 0.47 5.6e-20 Dupuytren's disease; CRC cis rs1639906 0.560 rs1108036 chr7:2263354 A/G cg19897017 chr7:2163380 MAD1L1 0.43 6.32 0.33 8.51e-10 Colonoscopy-negative controls vs population controls; CRC cis rs262150 0.659 rs2527237 chr7:158798494 A/G cg10570241 chr7:158785291 NA -0.45 -7.83 -0.4 6.74e-14 Facial morphology (factor 20); CRC cis rs9399135 0.660 rs9376072 chr6:135280519 G/C cg24558204 chr6:135376177 HBS1L 0.53 8.2 0.41 5.53e-15 Red blood cell count; CRC cis rs722599 0.748 rs731952 chr14:75366447 A/G cg08847533 chr14:75593920 NEK9 0.42 5.7 0.3 2.63e-8 IgG glycosylation; CRC cis rs9894429 1.000 rs7213129 chr17:79581573 C/T cg21984481 chr17:79567631 NPLOC4 -0.53 -9.8 -0.48 4.52e-20 Eye color traits; CRC cis rs6933660 0.800 rs6930557 chr6:151755806 G/A cg14416726 chr6:151773293 C6orf211;RMND1 -0.59 -8.74 -0.43 1.22e-16 Menarche (age at onset); CRC cis rs7705042 0.826 rs13184323 chr5:141494719 T/G cg08523384 chr5:141488047 NDFIP1 -0.34 -5.9 -0.31 9e-9 Asthma; CRC cis rs2153535 0.580 rs1119689 chr6:8460754 C/G cg21535247 chr6:8435926 SLC35B3 0.5 7.5 0.38 6.16e-13 Motion sickness; CRC cis rs6502050 0.835 rs66932937 chr17:80116803 G/A cg25804541 chr17:80189381 SLC16A3 -0.3 -5.88 -0.31 9.83e-9 Life satisfaction; CRC cis rs7552404 0.691 rs1770890 chr1:76401117 A/G cg10523679 chr1:76189770 ACADM -0.62 -7.95 -0.4 2.94e-14 Blood metabolite levels;Acylcarnitine levels; CRC cis rs7635879 0.533 rs12486721 chr3:193744854 A/G cg01524723 chr3:193718032 NA -0.54 -7.55 -0.38 4.43e-13 Breastfeeding duration; CRC cis rs875971 0.862 rs6960446 chr7:65733259 A/G cg12463550 chr7:65579703 CRCP -0.5 -6.72 -0.35 8.01e-11 Aortic root size; CRC cis rs950169 1.000 rs12915234 chr15:84758301 G/A cg17507749 chr15:85114479 UBE2QP1 0.77 11.92 0.55 1.78e-27 Schizophrenia; CRC cis rs4423214 0.879 rs1792282 chr11:71135166 G/A cg13043300 chr11:71146211 DHCR7 -0.42 -5.82 -0.31 1.37e-8 Vitamin D levels; CRC cis rs875971 1.000 rs2077593 chr7:65892530 A/G cg12463550 chr7:65579703 CRCP 0.48 6.78 0.35 5.41e-11 Aortic root size; CRC cis rs1799949 0.894 rs36062488 chr17:41337472 C/T cg23758822 chr17:41437982 NA -0.85 -15.89 -0.66 1.31e-42 Menopause (age at onset); CRC cis rs9916302 0.706 rs7212621 chr17:37527911 T/G cg15445000 chr17:37608096 MED1 -0.35 -6.17 -0.32 2.02e-9 Glomerular filtration rate (creatinine); CRC cis rs8077889 0.703 rs231531 chr17:41946180 A/C cg26893861 chr17:41843967 DUSP3 0.66 7.87 0.4 5.31e-14 Triglycerides; CRC cis rs4664293 0.967 rs10803758 chr2:160548219 T/C cg08347373 chr2:160653686 CD302 -0.38 -6.18 -0.32 1.9e-9 Monocyte percentage of white cells; CRC trans rs7618501 1.000 rs2271960 chr3:49878078 A/G cg21582582 chr3:182698605 DCUN1D1 0.52 7.52 0.38 5.33e-13 Intelligence (multi-trait analysis); CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg17114402 chr2:97778470 ANKRD36 -0.42 -6.0 -0.31 5.25e-9 Myopia (pathological); CRC cis rs798502 0.522 rs7790322 chr7:2830498 C/T cg19346786 chr7:2764209 NA -0.36 -6.68 -0.35 1.05e-10 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Inflammatory bowel disease;Waist circumference adjusted for BMI in non-smokers;Ulcerative colitis;Waist circumference adjusted for body mass index;Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction); CRC cis rs853679 0.542 rs9393892 chr6:28081394 A/G cg12963246 chr6:28129442 ZNF389 0.51 5.95 0.31 6.77e-9 Depression; CRC cis rs2421770 0.530 rs7945809 chr11:35369253 G/A cg13971030 chr11:35366721 SLC1A2 -0.38 -6.66 -0.34 1.16e-10 Staphylococcus aureus nasal carriage (persistent); CRC cis rs9747201 0.925 rs11867806 chr17:80072049 A/G cg09264619 chr17:80180166 NA 0.49 7.08 0.36 8.59e-12 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs459193 1.000 rs40271 chr5:55796319 A/G cg26646659 chr5:55776364 NA -0.48 -6.6 -0.34 1.65e-10 Coronary artery disease;Type 2 diabetes;Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);Waist-to-hip ratio adjusted for BMI in non-smokers;Waist-to-hip ratio adjusted for BMI (smoking interaction);Waist-to-hip ratio adjusted for body mass index;Waist-hip ratio;Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction); CRC cis rs2197308 0.765 rs7295711 chr12:37903631 C/T cg26384229 chr12:38710491 ALG10B 0.67 8.82 0.44 6.9e-17 Morning vs. evening chronotype; CRC cis rs2832191 0.791 rs4817270 chr21:30480368 G/A cg08807101 chr21:30365312 RNF160 -0.64 -10.44 -0.5 3.06e-22 Dental caries; CRC cis rs2839186 0.872 rs2250213 chr21:47674275 G/A cg12516959 chr21:47718080 NA -0.36 -6.11 -0.32 2.86e-9 Testicular germ cell tumor; CRC cis rs2032447 0.670 rs198820 chr6:26124243 G/A cg12310025 chr6:25882481 NA 0.45 6.23 0.32 1.43e-9 Intelligence (multi-trait analysis); CRC cis rs7945705 0.870 rs1109305 chr11:8955272 C/T cg12365402 chr11:9010492 NRIP3 0.48 7.74 0.39 1.26e-13 Hemoglobin concentration; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg07756108 chr2:203130955 NOP58 0.47 6.1 0.32 2.92e-9 Thyroid stimulating hormone; CRC cis rs12142240 0.698 rs1135460 chr1:46815970 T/C cg14993813 chr1:46806288 NSUN4 -0.5 -6.4 -0.33 5.38e-10 Menopause (age at onset); CRC cis rs17345786 0.798 rs9817043 chr3:101281852 A/G cg11279151 chr3:101281821 RG9MTD1 -0.7 -9.58 -0.47 2.54e-19 Colonoscopy-negative controls vs population controls; CRC cis rs6694672 1.000 rs7541429 chr1:197099485 A/G cg13682187 chr1:196946512 CFHR5 0.43 6.97 0.36 1.69e-11 Asthma; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg18641478 chr19:17970431 RPL18AP3;RPL18A 0.46 6.35 0.33 7.29e-10 Anxiety disorder; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg20899340 chr17:60143175 MED13 0.42 6.37 0.33 6.23e-10 Intelligence (multi-trait analysis); CRC cis rs853679 0.585 rs201004 chr6:27804934 T/C cg06470822 chr6:28175283 NA 0.62 6.84 0.35 3.92e-11 Depression; CRC cis rs9649213 0.537 rs6465663 chr7:97918883 C/G cg00277769 chr7:97922759 BAIAP2L1 -0.61 -10.81 -0.51 1.7e-23 Prostate cancer (SNP x SNP interaction); CRC cis rs1395 0.778 rs6749393 chr2:27451000 C/T cg14242246 chr2:27434262 C2orf28;SLC5A6 0.43 7.87 0.4 5.17e-14 Blood metabolite levels; CRC cis rs870825 0.616 rs4444872 chr4:185628405 A/G cg04058563 chr4:185651563 MLF1IP 0.78 9.98 0.48 1.18e-20 Blood protein levels; CRC cis rs6598955 1.000 rs6598955 chr1:26619649 C/T cg04990556 chr1:26633338 UBXN11 0.81 12.19 0.56 1.9e-28 Obesity-related traits; CRC cis rs11105298 0.891 rs10858898 chr12:89922111 A/G cg08166232 chr12:89918718 WDR51B;GALNT4 -0.62 -7.78 -0.39 9.18e-14 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; CRC cis rs16867321 0.901 rs2368168 chr2:181355888 G/T cg23363182 chr2:181467187 NA -0.49 -5.96 -0.31 6.54e-9 Obesity; CRC trans rs7976838 0.831 rs61935606 chr12:60242347 A/G cg16974014 chr22:22007515 MIR130B 0.49 5.96 0.31 6.46e-9 Response to zileuton treatment in asthma (FEV1 change interaction); CRC cis rs644799 0.710 rs3748253 chr11:95519506 G/A cg03916912 chr11:95522834 CEP57;FAM76B 0.86 15.82 0.66 2.48e-42 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs6964587 0.934 rs35968894 chr7:91762145 A/G cg01689657 chr7:91764605 CYP51A1 0.36 5.92 0.31 8.07e-9 Breast cancer; CRC cis rs12580194 0.556 rs58780687 chr12:55736498 A/C cg19537932 chr12:55886519 OR6C68 -0.7 -8.89 -0.44 4.2e-17 Cancer; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg09254823 chr19:13885429 C19orf53 0.39 6.14 0.32 2.34e-9 Liver disease severity in Alagille syndrome; CRC cis rs9291683 0.588 rs3796842 chr4:9995851 A/T cg00071950 chr4:10020882 SLC2A9 0.59 11.17 0.52 8.72e-25 Bone mineral density; CRC cis rs3219474 0.505 rs487174 chr1:46009536 C/T cg06784218 chr1:46089804 CCDC17 0.64 6.64 0.34 1.29e-10 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs2760061 0.583 rs708124 chr1:228220771 A/T cg02753203 chr1:228287806 NA 0.99 16.47 0.67 7.39e-45 Diastolic blood pressure; CRC cis rs4713118 0.699 rs573179 chr6:27849676 C/A cg20933634 chr6:27740509 NA 0.53 6.86 0.35 3.39e-11 Parkinson's disease; CRC trans rs10504229 1.000 rs17816781 chr8:58186161 A/T cg04077850 chr5:125800366 GRAMD3 0.37 6.27 0.33 1.15e-9 Developmental language disorder (linguistic errors); CRC cis rs8077889 0.672 rs1234612 chr17:41840802 A/G cg26893861 chr17:41843967 DUSP3 0.96 16.34 0.67 2.42e-44 Triglycerides; CRC cis rs1983170 0.735 rs963910 chr1:92014136 T/C cg25838465 chr1:92012736 NA -0.41 -5.91 -0.31 8.72e-9 Eosinophil percentage of white cells; CRC trans rs2303319 0.504 rs62189048 chr2:162613494 G/C cg10272801 chr16:14013773 ERCC4 -0.68 -6.07 -0.32 3.49e-9 Cognitive function; CRC cis rs10782582 0.593 rs17647178 chr1:76210524 A/G cg10523679 chr1:76189770 ACADM -0.41 -5.97 -0.31 6.12e-9 Daytime sleep phenotypes; CRC cis rs929596 0.639 rs7571915 chr2:234586574 G/A cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.48 -7.17 -0.37 5.08e-12 Total bilirubin levels in HIV-1 infection; CRC cis rs1639906 0.527 rs1639919 chr7:2262934 C/G cg19897017 chr7:2163380 MAD1L1 0.4 5.88 0.31 1.02e-8 Colonoscopy-negative controls vs population controls; CRC cis rs9322193 0.923 rs9505982 chr6:149939601 G/A cg07701084 chr6:150067640 NUP43 0.52 7.62 0.39 2.76e-13 Lung cancer; CRC trans rs330071 0.686 rs4841139 chr8:9249210 C/T cg06636001 chr8:8085503 FLJ10661 0.45 6.46 0.34 3.83e-10 Acne (severe); CRC cis rs7113874 0.589 rs10769907 chr11:8457237 G/A cg17679104 chr11:8615758 STK33 -0.34 -5.61 -0.3 4.37e-8 Body mass index in physically active individuals;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs7909074 1.000 rs6593447 chr10:45400235 G/A cg05187965 chr10:45406764 TMEM72 -0.36 -8.27 -0.42 3.24e-15 Mean corpuscular volume; CRC cis rs2832191 0.791 rs2832198 chr21:30498240 C/T cg24692254 chr21:30365293 RNF160 0.68 11.61 0.54 2.31e-26 Dental caries; CRC cis rs6951245 1.000 rs77346188 chr7:1114023 C/A cg26224354 chr7:1096374 C7orf50;GPR146 -0.94 -12.2 -0.56 1.65e-28 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs155076 0.666 rs2015241 chr13:21888254 A/G cg23743428 chr13:21893420 NA -0.39 -5.92 -0.31 8.02e-9 White matter hyperintensity burden; CRC cis rs116095464 0.558 rs6881920 chr5:222411 T/C cg22857025 chr5:266934 NA -1.23 -16.9 -0.68 1.4300000000000001e-46 Breast cancer; CRC cis rs9322193 0.962 rs3763163 chr6:150140906 G/T cg07701084 chr6:150067640 NUP43 0.47 6.64 0.34 1.27e-10 Lung cancer; CRC cis rs2228479 0.850 rs62052714 chr16:89857180 T/C cg06558623 chr16:89946397 TCF25 1.16 11.41 0.53 1.27e-25 Skin colour saturation; CRC cis rs4713118 0.513 rs149944 chr6:28002818 C/T cg10876282 chr6:28092338 ZSCAN16 0.46 6.34 0.33 7.76e-10 Parkinson's disease; CRC cis rs6502050 0.835 rs6502067 chr17:80111205 A/G cg22110888 chr17:80059540 CCDC57 0.4 6.44 0.33 4.17e-10 Life satisfaction; CRC cis rs9787249 0.957 rs7548120 chr1:40204424 A/T cg02773041 chr1:40204384 PPIE 0.63 9.23 0.45 3.51e-18 Blood protein levels; CRC cis rs9457247 0.765 rs9459838 chr6:167426599 C/G cg07741184 chr6:167504864 NA 0.39 6.64 0.34 1.3100000000000001e-10 Crohn's disease; CRC cis rs4713118 0.911 rs2394000 chr6:27686991 A/G cg12273811 chr6:28175739 NA 0.53 7.19 0.37 4.49e-12 Parkinson's disease; CRC trans rs116095464 0.558 rs6874745 chr5:264527 A/G cg00938859 chr5:1591904 SDHAP3 0.73 7.89 0.4 4.53e-14 Breast cancer; CRC cis rs9467160 1.000 rs9467157 chr6:24440644 C/T cg16211469 chr6:24423932 MRS2 0.36 5.74 0.3 2.19e-8 Liver enzyme levels; CRC cis rs10504229 0.683 rs17194529 chr8:58105647 A/G cg21724239 chr8:58056113 NA 0.77 9.69 0.47 1.05e-19 Developmental language disorder (linguistic errors); CRC cis rs806215 1.000 rs712701 chr7:127251188 T/G cg25922125 chr7:127225783 GCC1 0.58 6.32 0.33 8.27e-10 Type 2 diabetes; CRC cis rs561341 0.882 rs2521594 chr17:30302087 C/T cg19193384 chr17:30244184 NA -0.63 -7.33 -0.37 1.82e-12 Hip circumference adjusted for BMI; CRC trans rs916888 0.773 rs199535 chr17:44822662 A/G cg22433210 chr17:43662623 NA 0.93 9.84 0.48 3.44e-20 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs10751667 1.000 rs10794349 chr11:945678 T/C cg01483505 chr11:975446 AP2A2 0.39 5.85 0.31 1.2e-8 Alzheimer's disease (late onset); CRC trans rs9858542 1.000 rs13085791 chr3:49721798 C/A cg21582582 chr3:182698605 DCUN1D1 -0.59 -7.14 -0.37 6.03e-12 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs6840360 0.593 rs1429558 chr4:152685406 A/T cg09659197 chr4:152720779 NA 0.42 8.61 0.43 3.01e-16 Intelligence (multi-trait analysis); CRC cis rs1267303 0.675 rs1267308 chr1:46987718 A/G cg25110126 chr1:46999211 NA -0.57 -8.11 -0.41 1.02e-14 Monobrow; CRC cis rs4731207 0.569 rs1986124 chr7:124641717 A/C cg23710748 chr7:124431027 NA -0.39 -6.25 -0.33 1.24e-9 Cutaneous malignant melanoma; CRC cis rs7259376 0.936 rs10423736 chr19:22596132 C/T cg02657401 chr19:22469223 NA 0.31 6.82 0.35 4.25e-11 Menopause (age at onset); CRC cis rs4843747 0.671 rs13334603 chr16:88116016 T/C cg17633681 chr16:88106987 BANP 0.85 14.76 0.63 3.48e-38 Menopause (age at onset); CRC cis rs8078723 0.668 rs3859192 chr17:38128648 C/T cg17467752 chr17:38218738 THRA 0.63 9.51 0.46 4.15e-19 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); CRC cis rs1448094 0.511 rs10863071 chr12:86145813 A/G cg18827107 chr12:86230957 RASSF9 0.38 5.99 0.31 5.49e-9 Major depressive disorder; CRC cis rs9322817 0.902 rs4336470 chr6:105180785 C/T cg02098413 chr6:105308735 HACE1 -0.36 -6.61 -0.34 1.51e-10 Thyroid stimulating hormone; CRC cis rs28386778 0.724 rs35092235 chr17:61944621 T/C cg06873352 chr17:61820015 STRADA 0.76 14.03 0.61 2.19e-35 Prudent dietary pattern; CRC cis rs972578 0.967 rs738392 chr22:43340279 G/T cg01576275 chr22:43409880 NA -0.45 -7.23 -0.37 3.48e-12 Mean platelet volume; CRC cis rs9491140 0.539 rs11755888 chr6:124693042 A/G cg19267163 chr6:125004984 NKAIN2 0.47 6.08 0.32 3.38e-9 Neuroticism; CRC cis rs34375054 0.526 rs117431213 chr12:125675271 C/G cg06287003 chr12:125626642 AACS -0.52 -7.1 -0.36 7.89e-12 Post bronchodilator FEV1/FVC ratio; CRC trans rs2727020 0.573 rs7925419 chr11:49231859 C/T cg03929089 chr4:120376271 NA -0.64 -9.99 -0.48 1.1e-20 Coronary artery disease; CRC cis rs875971 0.929 rs778682 chr7:65837934 A/G cg11764359 chr7:65958608 NA 0.61 9.95 0.48 1.41e-20 Aortic root size; CRC cis rs10540 1.000 rs116101630 chr11:506826 G/C cg03934478 chr11:495069 RNH1 0.67 7.46 0.38 7.61e-13 Body mass index; CRC cis rs7769051 1.000 rs9399041 chr6:133096233 T/G cg07930552 chr6:133119739 C6orf192 0.59 7.01 0.36 1.33e-11 Type 2 diabetes nephropathy; CRC trans rs2228479 0.850 rs11647174 chr16:89958538 G/A cg21302420 chr1:112162376 RAP1A 0.83 7.41 0.38 1.07e-12 Skin colour saturation; CRC cis rs7772486 0.875 rs1331637 chr6:146337087 T/C cg23711669 chr6:146136114 FBXO30 0.67 11.53 0.54 4.5e-26 Lobe attachment (rater-scored or self-reported); CRC cis rs6502050 0.805 rs62080003 chr17:80078957 C/T cg02741985 chr17:80059408 CCDC57 -0.44 -7.2 -0.37 4.13e-12 Life satisfaction; CRC cis rs514406 0.679 rs960570 chr1:53237763 A/G cg25767906 chr1:53392781 SCP2 0.52 8.1 0.41 1.05e-14 Monocyte count; CRC cis rs13108904 0.652 rs2878539 chr4:1243877 C/T cg02018176 chr4:1364513 KIAA1530 0.35 5.84 0.31 1.26e-8 Obesity-related traits; CRC trans rs2303319 0.504 rs72873603 chr2:162469665 C/T cg12500891 chr11:57225987 NA -0.67 -6.03 -0.32 4.43e-9 Cognitive function; CRC cis rs853679 0.517 rs9380060 chr6:28132603 G/A cg23161317 chr6:28129485 ZNF389 0.53 6.43 0.33 4.52e-10 Depression; CRC trans rs4714291 0.802 rs3008833 chr6:39986303 G/A cg02267698 chr19:7991119 CTXN1 -0.52 -7.19 -0.37 4.27e-12 Strep throat; CRC cis rs7953249 0.656 rs2251468 chr12:121405126 A/C cg02403541 chr12:121454288 C12orf43 0.43 6.25 0.33 1.26e-9 Invasive epithelial ovarian cancer;High-grade serous ovarian cancer;Chronic obstructive pulmonary disease-related biomarkers;N-glycan levels;Serous invasive ovarian cancer;Epithelial ovarian cancer; CRC cis rs9325144 0.555 rs4882279 chr12:38688918 C/A cg26384229 chr12:38710491 ALG10B 0.54 8.16 0.41 7.11e-15 Morning vs. evening chronotype; CRC cis rs7208859 0.573 rs73277974 chr17:29189869 A/G cg14008862 chr17:28927542 LRRC37B2 0.55 5.74 0.3 2.12e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs2749592 0.550 rs9733309 chr10:37882405 G/A cg25427524 chr10:38739819 LOC399744 0.66 10.99 0.52 4e-24 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs4363385 0.782 rs10788857 chr1:153024941 T/G cg25856811 chr1:152973957 SPRR3 -0.28 -7.58 -0.39 3.63e-13 Inflammatory skin disease; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg16527794 chr11:47600580 NDUFS3;KBTBD4 -0.39 -6.11 -0.32 2.78e-9 Myopia (pathological); CRC cis rs2976388 1.000 rs2294010 chr8:143762430 A/G cg22687807 chr8:143858763 LYNX1 -0.38 -6.63 -0.34 1.36e-10 Urinary tract infection frequency; CRC trans rs7615952 0.546 rs11717632 chr3:125321130 G/C cg02560186 chr11:3602584 NA -0.57 -6.97 -0.36 1.73e-11 Blood pressure (smoking interaction); CRC cis rs79387448 0.745 rs17027442 chr2:103164948 A/G cg00507830 chr2:103233733 NA -0.5 -5.63 -0.3 3.81e-8 Gut microbiota (bacterial taxa); CRC cis rs9322193 0.923 rs6913486 chr6:150026196 C/T cg05861140 chr6:150128134 PCMT1 0.37 5.81 0.31 1.45e-8 Lung cancer; CRC cis rs6500395 0.962 rs11647046 chr16:48623217 T/C cg04672837 chr16:48644449 N4BP1 0.42 6.04 0.32 4.1e-9 Response to tocilizumab in rheumatoid arthritis; CRC cis rs910316 0.934 rs8006587 chr14:75664939 A/G cg03030879 chr14:75389066 RPS6KL1 -0.41 -6.34 -0.33 7.67e-10 Height; CRC cis rs6951245 0.554 rs11544331 chr7:1131411 C/T cg18402987 chr7:1209562 NA 0.55 6.62 0.34 1.5e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs394563 0.591 rs237026 chr6:149720681 G/A cg16235748 chr6:149772707 ZC3H12D -0.39 -7.01 -0.36 1.37e-11 Dupuytren's disease; CRC cis rs9549367 0.713 rs2476328 chr13:113829350 C/T cg00898013 chr13:113819073 PROZ 0.52 7.69 0.39 1.67e-13 Platelet distribution width; CRC cis rs853679 0.517 rs2275508 chr6:28094731 T/C cg12273811 chr6:28175739 NA 0.71 9.14 0.45 6.45e-18 Depression; CRC cis rs826838 0.935 rs11169508 chr12:39173385 C/T cg13010199 chr12:38710504 ALG10B 0.43 5.66 0.3 3.28e-8 Heart rate; CRC cis rs875971 1.000 rs4718343 chr7:65874288 T/G cg18912574 chr7:65842487 NCRNA00174 0.36 6.18 0.32 1.88e-9 Aortic root size; CRC cis rs2708240 0.666 rs1861010 chr7:147601401 G/C cg02373104 chr7:147601429 MIR548F3;CNTNAP2 -0.44 -6.42 -0.33 4.87e-10 QT interval (drug interaction); CRC cis rs1448094 0.512 rs61930861 chr12:86245023 G/T cg25456477 chr12:86230367 RASSF9 0.32 5.67 0.3 3.13e-8 Major depressive disorder; CRC cis rs6952808 0.723 rs4721282 chr7:2025040 A/G cg22963979 chr7:1858916 MAD1L1 -0.47 -6.96 -0.36 1.8e-11 Bipolar disorder and schizophrenia; CRC cis rs11764590 0.694 rs10241537 chr7:2083358 A/G cg23422044 chr7:1970798 MAD1L1 -0.42 -5.93 -0.31 7.57e-9 Neuroticism; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg25764190 chr19:44037015 ZNF575 0.58 7.72 0.39 1.39e-13 Thyroid stimulating hormone; CRC cis rs12476592 0.602 rs262536 chr2:63906926 T/C cg10828910 chr2:63850056 LOC388955 0.52 6.39 0.33 5.59e-10 Childhood ear infection; CRC cis rs6964587 0.867 rs12704637 chr7:91874686 C/T cg01689657 chr7:91764605 CYP51A1 0.35 5.82 0.31 1.37e-8 Breast cancer; CRC cis rs7528419 0.895 rs599839 chr1:109822166 A/G cg00908766 chr1:109817496 CELSR2 -0.48 -8.69 -0.43 1.8e-16 Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease);Myocardial infarction;Lipoprotein-associated phospholipase A2 activity and mass;Lipoprotein-associated phospholipase A2 activity change in response to darapladib treatment in cardiovascular disease;Cholesterol, total;Coronary artery disease; CRC cis rs10504229 0.683 rs7464038 chr8:58111908 T/C cg21724239 chr8:58056113 NA 0.54 7.21 0.37 3.76e-12 Developmental language disorder (linguistic errors); CRC trans rs1455244 0.700 rs7229302 chr18:11508904 G/T cg21582570 chr1:113257894 PPM1J 0.39 6.19 0.32 1.76e-9 Schizophrenia; CRC cis rs10791097 0.694 rs3190331 chr11:130748131 C/T cg12179176 chr11:130786555 SNX19 -0.75 -12.59 -0.57 6.29e-30 Autism spectrum disorder or schizophrenia;Schizophrenia; CRC cis rs919433 0.680 rs699319 chr2:198281776 C/A cg10820045 chr2:198174542 NA 0.38 6.31 0.33 9.24e-10 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC cis rs2019137 0.539 rs11123170 chr2:113978940 C/G cg07772999 chr2:113993052 PAX8;LOC440839;LOC654433 0.58 8.51 0.42 6.24e-16 Lymphocyte counts; CRC cis rs4713118 0.955 rs9468204 chr6:27688809 C/T cg03623178 chr6:28175578 NA 0.63 8.32 0.42 2.44e-15 Parkinson's disease; CRC cis rs7937682 0.774 rs59921976 chr11:111473088 G/A cg09085632 chr11:111637200 PPP2R1B -0.97 -18.58 -0.72 3.48e-53 Primary sclerosing cholangitis; CRC cis rs262150 0.567 rs2527177 chr7:158804737 T/C cg10570241 chr7:158785291 NA 0.38 6.44 0.33 4.26e-10 Facial morphology (factor 20); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg11837215 chr10:13344517 NA 0.5 6.84 0.35 3.81e-11 Response to antipsychotic treatment; CRC cis rs7119 0.717 rs12902896 chr15:77809150 G/T cg10437265 chr15:77819839 NA -0.68 -12.94 -0.58 3.03e-31 Type 2 diabetes; CRC cis rs9372498 0.536 rs55697388 chr6:118891544 C/T cg18833306 chr6:118973337 C6orf204 0.45 5.84 0.31 1.24e-8 Diastolic blood pressure; CRC cis rs2046867 0.818 rs1502758 chr3:72865126 A/G cg25664220 chr3:72788482 NA -0.46 -6.65 -0.34 1.21e-10 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg04238871 chr10:126431886 FAM53B 0.48 6.71 0.35 8.35e-11 Response to antipsychotic treatment; CRC cis rs6088590 0.561 rs6088527 chr20:33155841 C/T cg08999081 chr20:33150536 PIGU 0.64 12.56 0.57 7.8e-30 Coronary artery disease; CRC cis rs11997175 0.846 rs34860600 chr8:33761566 C/A ch.8.33884649F chr8:33765107 NA 0.53 8.07 0.41 1.33e-14 Body mass index; CRC cis rs763121 0.853 rs2072796 chr22:39064230 A/G cg06544989 chr22:39130855 UNC84B 0.46 7.06 0.36 9.91e-12 Menopause (age at onset); CRC cis rs6502050 0.799 rs7501461 chr17:80109806 C/T cg11859384 chr17:80120422 CCDC57 -0.37 -5.85 -0.31 1.16e-8 Life satisfaction; CRC cis rs1465370 0.644 rs1558919 chr7:130029508 A/T cg03229158 chr7:130009420 NA 0.42 6.09 0.32 3.13e-9 Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction);Waist circumference adjusted for BMI in active individuals;Waist circumference adjusted for body mass index; CRC cis rs10256972 0.553 rs4236381 chr7:1165723 A/C cg18402987 chr7:1209562 NA 0.53 7.8 0.4 8.32e-14 Longevity;Endometriosis; CRC cis rs524023 1.000 rs537246 chr11:64360630 G/A cg14139581 chr11:64358342 SLC22A12 0.37 5.88 0.31 1.03e-8 Urate levels in obese individuals; CRC cis rs4237845 0.637 rs7299249 chr12:58343710 C/T cg02175503 chr12:58329896 NA 0.76 11.97 0.55 1.2100000000000001e-27 Intelligence (multi-trait analysis); CRC cis rs9487051 0.836 rs9400270 chr6:109607488 G/A cg12927641 chr6:109611667 NA -0.39 -6.99 -0.36 1.54e-11 Reticulocyte fraction of red cells; CRC cis rs12541635 0.966 rs6987512 chr8:106998770 C/T cg10147462 chr8:107024639 NA 0.42 6.93 0.36 2.16e-11 Age of smoking initiation; CRC cis rs1728785 1.000 rs864742 chr16:68575309 T/C cg02972257 chr16:68554789 NA -0.58 -7.23 -0.37 3.43e-12 Ulcerative colitis; CRC cis rs7208859 0.673 rs11653955 chr17:29033292 C/A cg01831904 chr17:28903510 LRRC37B2 -0.63 -6.4 -0.33 5.2400000000000005e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs13191362 1.000 rs66594243 chr6:163169024 T/C cg14584255 chr6:163149320 PACRG;PARK2 0.4 5.65 0.3 3.46e-8 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC trans rs1455244 0.700 rs7229302 chr18:11508904 G/T cg11371493 chr20:30795352 POFUT1;PLAGL2 0.43 6.61 0.34 1.53e-10 Schizophrenia; CRC cis rs4400599 0.606 rs7542975 chr1:154204813 G/A cg26808167 chr1:154192205 UBAP2L;C1orf43 -0.37 -5.74 -0.3 2.21e-8 Platelet distribution width; CRC cis rs2279817 1.000 rs4920619 chr1:18023112 A/G cg21791023 chr1:18019539 ARHGEF10L 0.51 6.32 0.33 8.62e-10 Neuroticism; CRC cis rs9902453 0.780 rs3115093 chr17:28039755 G/A cg26525008 chr17:28256777 EFCAB5;SSH2 0.66 10.92 0.52 6.98e-24 Coffee consumption (cups per day); CRC cis rs1223397 0.938 rs34505804 chr6:13292514 G/A cg07912922 chr6:13274314 PHACTR1 0.54 6.46 0.34 3.68e-10 Blood pressure; CRC cis rs898097 0.578 rs8069697 chr17:80908110 T/C cg15369054 chr17:80825471 TBCD -0.36 -6.02 -0.31 4.68e-9 Breast cancer; CRC cis rs7487075 0.820 rs7953659 chr12:46698683 A/G cg22049899 chr12:47219821 SLC38A4 0.32 6.18 0.32 1.92e-9 Itch intensity from mosquito bite; CRC cis rs864537 0.622 rs2949661 chr1:167424924 C/T cg09179987 chr1:167433047 CD247 0.49 7.18 0.37 4.58e-12 Celiac disease or Rheumatoid arthritis;Celiac disease; CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg10089145 chr11:130030103 ST14 -0.55 -6.97 -0.36 1.77e-11 Diisocyanate-induced asthma; CRC cis rs7666738 0.830 rs991169 chr4:98928567 C/A cg17366294 chr4:99064904 C4orf37 0.43 7.32 0.37 1.95e-12 Colonoscopy-negative controls vs population controls; CRC trans rs8002861 0.875 rs12869697 chr13:44439169 T/C cg12856521 chr11:46389249 DGKZ -0.42 -6.88 -0.35 2.99e-11 Leprosy; CRC cis rs4474465 0.688 rs4367973 chr11:78284545 C/A cg27205649 chr11:78285834 NARS2 0.53 6.81 0.35 4.75e-11 Alzheimer's disease (survival time); CRC cis rs7772486 0.686 rs702305 chr6:145973840 A/G cg23711669 chr6:146136114 FBXO30 -0.65 -10.82 -0.51 1.55e-23 Lobe attachment (rater-scored or self-reported); CRC cis rs6502050 0.835 rs8067138 chr17:80111026 T/C cg22110888 chr17:80059540 CCDC57 0.4 6.44 0.33 4.17e-10 Life satisfaction; CRC cis rs7666738 0.830 rs11097600 chr4:98959564 T/G cg05340658 chr4:99064831 C4orf37 0.58 8.95 0.44 2.7e-17 Colonoscopy-negative controls vs population controls; CRC cis rs1387259 0.839 rs7487682 chr12:48579665 A/C cg00601486 chr12:48723148 H1FNT -0.3 -5.71 -0.3 2.58e-8 Obstructive sleep apnea trait (apnea hypopnea index); CRC cis rs7107174 0.901 rs901105 chr11:77924607 A/C cg02023728 chr11:77925099 USP35 0.51 7.31 0.37 2.03e-12 Testicular germ cell tumor; CRC cis rs909674 0.541 rs5750812 chr22:39793079 G/A cg25956985 chr22:39795188 MAP3K7IP1 -0.42 -6.2 -0.32 1.69e-9 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; CRC cis rs875971 0.522 rs34973832 chr7:65396204 A/G cg05627663 chr7:65219948 SNORA22;CCT6P1 0.49 7.39 0.38 1.21e-12 Aortic root size; CRC cis rs6570726 0.764 rs366673 chr6:145814628 T/A cg05347473 chr6:146136440 FBXO30 0.4 6.25 0.33 1.29e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs8180040 1.000 rs295458 chr3:47385585 C/A cg27129171 chr3:47204927 SETD2 0.56 8.86 0.44 5.26e-17 Colorectal cancer; CRC cis rs2404602 0.583 rs12898415 chr15:76574232 C/T cg22467129 chr15:76604101 ETFA -0.49 -8.66 -0.43 2.21e-16 Blood metabolite levels; CRC cis rs35110281 0.837 rs7279968 chr21:45077398 C/G cg04455712 chr21:45112962 RRP1B 0.4 7.86 0.4 5.7e-14 Mean corpuscular volume; CRC cis rs3858526 0.917 rs9284148 chr11:5973185 G/C cg05234568 chr11:5960015 NA -0.58 -7.56 -0.38 4.04e-13 DNA methylation (variation); CRC cis rs2841277 0.708 rs28454709 chr14:105405942 G/A cg15352829 chr14:105391018 PLD4 -0.5 -10.94 -0.52 5.95e-24 Rheumatoid arthritis; CRC cis rs34172651 0.517 rs12927710 chr16:24790282 A/C cg06505273 chr16:24850292 NA 0.47 5.65 0.3 3.39e-8 Intelligence (multi-trait analysis); CRC cis rs765787 0.530 rs1631533 chr15:45518628 C/T cg24006582 chr15:45444508 DUOX1 -0.57 -8.65 -0.43 2.39e-16 Uric acid levels; CRC trans rs11764590 0.694 rs11773643 chr7:2104063 A/G cg11693508 chr17:37793320 STARD3 0.51 6.74 0.35 6.9e-11 Neuroticism; CRC cis rs6088580 0.602 rs6058064 chr20:33086622 A/G cg24642439 chr20:33292090 TP53INP2 0.41 6.71 0.35 8.57e-11 Glomerular filtration rate (creatinine); CRC cis rs2067615 0.524 rs4275715 chr12:107062246 C/T cg13491945 chr12:107078410 RFX4 0.35 6.15 0.32 2.21e-9 Heart rate; CRC cis rs7666738 0.830 rs28818218 chr4:98880575 A/C cg05340658 chr4:99064831 C4orf37 0.58 8.84 0.44 5.8e-17 Colonoscopy-negative controls vs population controls; CRC cis rs9814567 0.964 rs1534028 chr3:134284639 G/C cg06109529 chr3:134205091 CEP63;ANAPC13 -0.82 -12.36 -0.56 4.3e-29 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs9287719 0.649 rs6717431 chr2:10726046 A/G cg00105475 chr2:10696890 NA 0.44 7.0 0.36 1.43e-11 Prostate cancer; CRC cis rs7772486 0.790 rs7753092 chr6:146248863 C/T cg23711669 chr6:146136114 FBXO30 -0.74 -12.95 -0.58 2.8e-31 Lobe attachment (rater-scored or self-reported); CRC cis rs12477438 0.605 rs4585080 chr2:99557327 T/C cg14399236 chr2:99771627 LIPT1;TSGA10 -0.58 -8.0 -0.4 2.1e-14 Chronic sinus infection; CRC cis rs7208859 0.623 rs8080882 chr17:29081146 G/A cg13385521 chr17:29058706 SUZ12P 0.72 8.24 0.41 4.19e-15 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs8070740 1.000 rs8066928 chr17:5328155 T/C cg25236894 chr17:5323110 RPAIN;NUP88 0.48 6.98 0.36 1.65e-11 Menopause (age at onset); CRC cis rs1401999 0.510 rs3749438 chr3:183705184 G/A cg01324343 chr3:183735012 ABCC5 0.51 8.01 0.4 1.98e-14 Anterior chamber depth; CRC cis rs3750082 0.505 rs7807550 chr7:32984472 C/T cg05721444 chr7:32995514 FKBP9 0.52 6.53 0.34 2.44e-10 Glomerular filtration rate (creatinine); CRC cis rs7605827 0.930 rs1549015 chr2:15616458 T/C cg19274914 chr2:15703543 NA 0.39 5.9 0.31 8.83e-9 Educational attainment (years of education); CRC cis rs2576037 0.583 rs9947131 chr18:44534769 G/T cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.59 -8.85 -0.44 5.49e-17 Personality dimensions; CRC cis rs9660180 0.967 rs6603803 chr1:1812688 A/G cg05132306 chr1:1846340 CALML6 -0.49 -7.66 -0.39 2.07e-13 Body mass index; CRC cis rs6499129 1.000 rs12935253 chr16:67466430 T/C cg26727032 chr16:67993705 SLC12A4 -0.59 -6.92 -0.36 2.34e-11 Waist-to-hip ratio adjusted for body mass index; CRC cis rs7113874 0.513 rs2015629 chr11:8564426 A/T cg17679104 chr11:8615758 STK33 -0.37 -6.18 -0.32 1.86e-9 Body mass index in physically active individuals;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs7044106 0.791 rs10760116 chr9:123494681 C/T cg09586646 chr9:123605570 PSMD5;LOC253039 0.68 10.21 0.49 1.91e-21 Hip circumference adjusted for BMI; CRC cis rs9611565 0.625 rs9607819 chr22:41958862 C/G cg03806693 chr22:41940476 POLR3H -0.95 -11.82 -0.55 4.14e-27 Vitiligo; CRC cis rs2404602 1.000 rs2056544 chr15:76826003 G/A cg03037974 chr15:76606532 NA 0.57 9.51 0.46 4.32e-19 Blood metabolite levels; CRC cis rs262150 0.788 rs2657408 chr7:158782275 A/G cg07130601 chr7:158766826 NA 0.44 6.42 0.33 4.64e-10 Facial morphology (factor 20); CRC cis rs12701220 0.553 rs7782024 chr7:1157502 G/T cg02733842 chr7:1102375 C7orf50 -0.69 -8.46 -0.42 9.02e-16 Bronchopulmonary dysplasia; CRC cis rs7618915 0.547 rs11130311 chr3:52675005 T/C cg07507251 chr3:52567010 NT5DC2 0.42 6.04 0.32 4.11e-9 Bipolar disorder; CRC cis rs7264396 0.635 rs6060696 chr20:34522060 C/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.64 -10.51 -0.5 1.86e-22 Total cholesterol levels; CRC cis rs10540 0.818 rs12806089 chr11:501468 G/A cg03576123 chr11:487126 PTDSS2 -1.04 -10.79 -0.51 1.91e-23 Body mass index; CRC cis rs6500395 1.000 rs4785536 chr16:48712980 C/T cg04672837 chr16:48644449 N4BP1 -0.46 -6.79 -0.35 5.28e-11 Response to tocilizumab in rheumatoid arthritis; CRC cis rs992157 0.717 rs11692780 chr2:219149163 A/G cg04731861 chr2:219085781 ARPC2 0.33 6.88 0.35 2.94e-11 Colorectal cancer; CRC cis rs28386778 0.966 rs2008053 chr17:61954918 G/C cg06601766 chr17:61851465 DDX42;CCDC47 0.42 5.85 0.31 1.22e-8 Prudent dietary pattern; CRC cis rs11764590 0.543 rs55893771 chr7:2096255 C/T cg02825527 chr7:2087843 MAD1L1 -0.54 -6.58 -0.34 1.88e-10 Neuroticism; CRC cis rs12745968 0.589 rs12025792 chr1:93107408 C/T cg17283838 chr1:93427260 FAM69A -0.44 -5.92 -0.31 8.27e-9 Bipolar disorder and schizophrenia; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg00997172 chr20:32399000 CHMP4B 0.41 6.29 0.33 1.04e-9 Intelligence (multi-trait analysis); CRC cis rs9814567 1.000 rs1863913 chr3:134200205 C/T cg06541857 chr3:134203789 ANAPC13;CEP63 -0.39 -5.73 -0.3 2.3e-8 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs7447593 0.626 rs3812036 chr5:176813404 C/T cg05207973 chr5:176823642 SLC34A1 0.48 7.47 0.38 7.1e-13 Urinary electrolytes (magnesium/calcium ratio); CRC cis rs6543140 0.964 rs6543138 chr2:103066132 G/A cg04239558 chr2:103089729 SLC9A4 0.37 6.6 0.34 1.67e-10 Blood protein levels; CRC cis rs4803480 0.554 rs12983999 chr19:42070528 G/C cg08478046 chr19:42093086 CEACAM21 -0.29 -6.04 -0.32 4.23e-9 Schizophrenia; CRC cis rs7208859 0.673 rs9899943 chr17:29223925 G/A cg13385521 chr17:29058706 SUZ12P 0.69 7.93 0.4 3.48e-14 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs6496667 0.865 rs4622491 chr15:90885481 C/T cg04176472 chr15:90893244 GABARAPL3 0.57 6.73 0.35 7.68e-11 Rheumatoid arthritis; CRC trans rs974471 0.736 rs1956246 chr14:29669291 C/G cg01759126 chr2:68870892 NA -0.34 -5.96 -0.31 6.48e-9 Intelligence (multi-trait analysis);Body mass index in physically active individuals;Body mass index;Cognitive ability (multi-trait analysis);Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs919433 0.963 rs10153881 chr2:198171098 T/C cg10820045 chr2:198174542 NA -0.52 -9.11 -0.45 8.5e-18 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC trans rs9291683 0.595 rs13150928 chr4:10052961 G/T cg26043149 chr18:55253948 FECH 0.55 8.53 0.43 5.58e-16 Bone mineral density; CRC cis rs4474465 0.790 rs10899554 chr11:78265667 T/G cg27205649 chr11:78285834 NARS2 0.49 6.23 0.32 1.45e-9 Alzheimer's disease (survival time); CRC cis rs1448094 0.512 rs6539926 chr12:86244460 G/A cg00310523 chr12:86230176 RASSF9 0.33 5.62 0.3 3.97e-8 Major depressive disorder; CRC cis rs143626010 1 rs143626010 chr16:28539398 GTGTA/G cg16576597 chr16:28551801 NUPR1 0.52 7.67 0.39 1.92e-13 Mosquito bite size; CRC cis rs1003719 0.667 rs28666643 chr21:38455999 T/G cg10648535 chr21:38446584 PIGP;TTC3 0.47 6.4 0.33 5.47e-10 Eye color traits; CRC cis rs7613875 0.537 rs6446195 chr3:50070853 A/G cg24110177 chr3:50126178 RBM5 0.53 7.93 0.4 3.43e-14 Body mass index; CRC cis rs1008375 0.966 rs4698636 chr4:17632834 T/C cg15017067 chr4:17643749 FAM184B 0.36 5.7 0.3 2.69e-8 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs1891275 0.515 rs7092884 chr10:93483872 A/C cg07889827 chr10:93443413 NA 0.39 6.52 0.34 2.66e-10 Intelligence (multi-trait analysis); CRC cis rs10504229 0.953 rs66815941 chr8:58187306 C/T cg01721255 chr8:58191610 C8orf71 0.49 6.17 0.32 2e-9 Developmental language disorder (linguistic errors); CRC cis rs35306767 0.855 rs11253459 chr10:886402 C/T cg26597838 chr10:835615 NA 0.88 10.85 0.51 1.2e-23 Eosinophil percentage of granulocytes; CRC cis rs7246657 0.943 rs6508732 chr19:38000468 C/T cg23950597 chr19:37808831 NA -0.46 -5.63 -0.3 3.84e-8 Coronary artery calcification; CRC cis rs7584330 0.910 rs880930 chr2:238396872 G/C cg14458575 chr2:238380390 NA 0.74 13.53 0.6 1.76e-33 Prostate cancer; CRC cis rs7113874 0.524 rs6484485 chr11:8620740 A/G cg17679104 chr11:8615758 STK33 0.34 5.8 0.3 1.59e-8 Body mass index in physically active individuals;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs853679 0.882 rs9468300 chr6:28126840 C/T cg15786705 chr6:28176104 NA 0.7 5.78 0.3 1.74e-8 Depression; CRC cis rs2228479 0.850 rs9282681 chr16:89805914 T/C cg19635926 chr16:89946313 TCF25 0.68 6.14 0.32 2.35e-9 Skin colour saturation; CRC cis rs10450586 0.796 rs10437624 chr11:27307345 C/G cg10370305 chr11:27303972 NA 0.37 6.02 0.31 4.69e-9 Total body bone mineral density; CRC cis rs10504229 0.683 rs6999131 chr8:58127052 C/A cg21724239 chr8:58056113 NA 0.74 9.46 0.46 6.05e-19 Developmental language disorder (linguistic errors); CRC cis rs9549367 0.713 rs2476319 chr13:113836519 C/T cg00898013 chr13:113819073 PROZ 0.5 7.43 0.38 9.39e-13 Platelet distribution width; CRC cis rs7680126 0.500 rs4697935 chr4:10149593 C/T cg00071950 chr4:10020882 SLC2A9 -0.48 -6.09 -0.32 3.19e-9 Urate levels in lean individuals;Urate levels in overweight individuals;Urate levels in obese individuals; CRC cis rs12477438 0.520 rs1044575 chr2:99812070 G/A cg26064155 chr2:99771622 LIPT1;TSGA10 0.83 14.68 0.63 7.35e-38 Chronic sinus infection; CRC trans rs7647973 0.710 rs1491983 chr3:49639803 G/T cg21665057 chr3:196295764 WDR53;FBXO45 -0.65 -7.03 -0.36 1.17e-11 Menarche (age at onset); CRC cis rs1124376 1.000 rs73038113 chr3:20139025 T/A cg05072819 chr3:20081367 KAT2B 0.54 6.27 0.33 1.15e-9 Bipolar disorder and schizophrenia; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg00282216 chr8:145823653 KIAA1688 -0.47 -7.7 -0.39 1.5700000000000001e-13 Liver disease severity in Alagille syndrome; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg07283595 chr17:5372003 DHX33 0.42 6.21 0.32 1.57e-9 Intelligence (multi-trait analysis); CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg06080224 chr7:107204581 COG5;DUS4L 0.45 6.18 0.32 1.86e-9 Anxiety disorder; CRC cis rs8072100 0.807 rs2175290 chr17:45479917 C/A cg25173405 chr17:45401733 C17orf57 -0.48 -7.69 -0.39 1.74e-13 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs10504229 0.683 rs7000349 chr8:58114569 C/A cg04204079 chr8:58130323 NA -0.45 -5.84 -0.31 1.27e-8 Developmental language disorder (linguistic errors); CRC cis rs11608355 0.538 rs11611957 chr12:109801803 A/G cg19025524 chr12:109796872 NA -0.57 -9.12 -0.45 7.85e-18 Neuroticism; CRC cis rs9811920 0.809 rs4577503 chr3:99657922 G/A cg07805332 chr3:99536008 MIR548G;C3orf26 0.38 5.95 0.31 6.83e-9 Axial length; CRC cis rs17376456 0.877 rs10076052 chr5:93317762 C/T cg21475434 chr5:93447410 FAM172A 0.77 7.8 0.4 8.13e-14 Diabetic retinopathy; CRC cis rs7618915 0.501 rs34157897 chr3:52716937 T/C cg18404041 chr3:52824283 ITIH1 -0.4 -8.44 -0.42 1.04e-15 Bipolar disorder; CRC trans rs2228479 0.717 rs17226274 chr16:89850170 C/T cg21302420 chr1:112162376 RAP1A 0.69 5.96 0.31 6.37e-9 Skin colour saturation; CRC cis rs7089973 0.604 rs7904188 chr10:116610271 G/C cg23260525 chr10:116636907 FAM160B1 0.35 8.11 0.41 1.04e-14 Bipolar disorder or attention deficit hyperactivity disorder; CRC cis rs8177253 1.000 rs8177252 chr3:133480174 C/A cg01448562 chr3:133502909 NA -0.55 -9.54 -0.47 3.37e-19 Iron status biomarkers; CRC cis rs3771570 1.000 rs55645375 chr2:242269024 A/G cg21155796 chr2:242212141 HDLBP 0.64 6.97 0.36 1.72e-11 Prostate cancer; CRC cis rs1215050 0.740 rs185468 chr4:98756242 C/T cg05340658 chr4:99064831 C4orf37 0.47 6.95 0.36 1.93e-11 Waist-to-hip ratio adjusted for body mass index; CRC trans rs6557786 0.636 rs2445940 chr8:24787201 C/G cg10207787 chr8:26148195 PPP2R2A -0.55 -6.64 -0.34 1.3100000000000001e-10 Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 2 peripheral neuropathy); CRC cis rs7786808 0.552 rs896762 chr7:158182029 A/G cg09998033 chr7:158218633 PTPRN2 0.52 7.0 0.36 1.44e-11 Obesity-related traits; CRC cis rs72717009 0.825 rs7515174 chr1:161476949 C/G cg15358701 chr1:161410459 NA -0.62 -6.63 -0.34 1.39e-10 Rheumatoid arthritis; CRC cis rs4237845 0.611 rs4509811 chr12:58335142 A/G cg02175503 chr12:58329896 NA 0.76 11.93 0.55 1.64e-27 Intelligence (multi-trait analysis); CRC cis rs514406 0.607 rs6665324 chr1:53201610 G/A cg25767906 chr1:53392781 SCP2 0.37 5.86 0.31 1.12e-8 Monocyte count; CRC cis rs9768139 0.683 rs4909178 chr7:158117752 T/A cg25566285 chr7:158114605 PTPRN2 0.45 7.12 0.37 6.83e-12 Calcium levels; CRC cis rs2303745 0.589 rs7246262 chr19:17392483 C/G cg15110403 chr19:17392923 ANKLE1 -0.36 -5.92 -0.31 8.17e-9 Systemic lupus erythematosus; CRC cis rs13191362 1.000 rs13209728 chr6:162997533 A/C cg06582575 chr6:163149167 PACRG;PARK2 0.74 10.67 0.51 5.17e-23 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC trans rs9929218 1.000 rs9929218 chr16:68820946 G/A cg04657470 chr2:198365150 HSPE1;HSPD1 -0.79 -10.93 -0.52 6.14e-24 Colorectal cancer; CRC cis rs875971 0.895 rs7788984 chr7:65915616 A/G cg18912574 chr7:65842487 NCRNA00174 0.35 5.95 0.31 6.85e-9 Aortic root size; CRC cis rs10927875 0.541 rs1048334 chr1:16340761 T/C cg24140574 chr1:16342155 HSPB7 0.47 6.66 0.34 1.13e-10 Dilated cardiomyopathy; CRC cis rs12431939 1.000 rs12433445 chr14:51666091 G/A cg23942311 chr14:51606299 NA -0.54 -6.19 -0.32 1.76e-9 Cancer; CRC cis rs12325245 0.536 rs34737210 chr16:58549262 T/C cg05725404 chr16:58534157 NDRG4 -0.6 -5.6 -0.3 4.45e-8 Schizophrenia; CRC trans rs1728785 0.681 rs4783647 chr16:68558048 G/A cg04657470 chr2:198365150 HSPE1;HSPD1 -0.55 -6.03 -0.32 4.3e-9 Ulcerative colitis; CRC cis rs1499614 1.000 rs60326618 chr7:66166358 G/A cg25985355 chr7:65971099 NA -0.52 -5.92 -0.31 7.91e-9 Gout; CRC cis rs6502050 0.787 rs8080682 chr17:80058901 G/A cg13198984 chr17:80129470 CCDC57 -0.41 -7.01 -0.36 1.37e-11 Life satisfaction; CRC cis rs7618915 0.501 rs12486554 chr3:52742537 A/T cg15147215 chr3:52552868 STAB1 -0.61 -10.4 -0.5 4.17e-22 Bipolar disorder; CRC cis rs13064411 0.696 rs7610638 chr3:113139656 A/G cg10517650 chr3:113235015 CCDC52 -0.36 -5.92 -0.31 8.19e-9 Response to simvastatin treatment (PCSK9 protein level change); CRC cis rs12586317 0.547 rs28589276 chr14:35478865 A/G cg16230307 chr14:35515116 FAM177A1 0.85 9.86 0.48 2.83e-20 Psoriasis; CRC trans rs7615952 0.599 rs12485717 chr3:125707075 C/T cg07211511 chr3:129823064 LOC729375 0.77 10.57 0.5 1.14e-22 Blood pressure (smoking interaction); CRC cis rs2985684 0.748 rs2985686 chr14:50100683 C/G cg04989706 chr14:50066350 PPIL5 -0.56 -7.82 -0.4 7.17e-14 Carotid intima media thickness; CRC trans rs7027930 0.524 rs7023618 chr9:612425 C/G cg27061366 chr19:13044373 FARSA 0.51 6.21 0.32 1.59e-9 Pulmonary function decline; CRC cis rs67340775 0.541 rs200966 chr6:27862152 T/C cg19041857 chr6:27730383 NA -0.62 -6.88 -0.35 3.09e-11 Lung cancer in ever smokers; CRC cis rs740160 0.558 rs68164591 chr7:98904440 C/T cg24650262 chr7:98904301 NA 0.55 5.72 0.3 2.42e-8 Dehydroepiandrosterone sulphate levels; CRC cis rs4925114 0.568 rs4925109 chr17:17661802 A/G cg24612305 chr17:17875800 TOM1L2;LRRC48 -0.44 -6.71 -0.35 8.49e-11 Body mass index; CRC cis rs929596 0.606 rs7604115 chr2:234658116 C/T cg02227331 chr2:234663937 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 0.43 6.33 0.33 7.86e-10 Total bilirubin levels in HIV-1 infection; CRC cis rs2115630 0.691 rs2292462 chr15:85200754 G/T cg11189052 chr15:85197271 WDR73 -0.73 -12.69 -0.57 2.58e-30 P wave terminal force; CRC cis rs9640161 0.830 rs35840727 chr7:150063204 A/G cg21361702 chr7:150065534 REPIN1 0.44 5.61 0.3 4.23e-8 Blood protein levels;Circulating chemerin levels; CRC cis rs172166 0.561 rs149976 chr6:27987776 C/T cg15845792 chr6:28175446 NA -0.64 -9.49 -0.46 5.01e-19 Cardiac Troponin-T levels; CRC cis rs12586317 0.547 rs4982236 chr14:35468046 C/G cg16230307 chr14:35515116 FAM177A1 0.85 10.08 0.49 5.15e-21 Psoriasis; CRC trans rs12663356 0.528 rs9350359 chr6:21462624 C/T cg11248668 chr11:45826493 SLC35C1 0.4 6.01 0.31 4.93e-9 Crohn's disease; CRC cis rs847577 0.587 rs34307903 chr7:97728449 C/A cg00277769 chr7:97922759 BAIAP2L1 -0.41 -6.85 -0.35 3.69e-11 Breast cancer; CRC cis rs7811142 0.775 rs1636980 chr7:99938864 A/G cg23667466 chr7:100026434 MEPCE;ZCWPW1 -0.68 -9.23 -0.45 3.49e-18 Platelet count; CRC cis rs6952808 1.000 rs12699404 chr7:1894022 A/T cg04267008 chr7:1944627 MAD1L1 -0.83 -12.02 -0.55 8.02e-28 Bipolar disorder and schizophrenia; CRC cis rs344364 0.511 rs12599337 chr16:1946751 A/G cg09830162 chr16:1889614 FAHD1;C16orf73 0.7 8.62 0.43 2.86e-16 Glomerular filtration rate in chronic kidney disease; CRC cis rs9443189 0.526 rs775060 chr6:76373567 G/A cg01950844 chr6:76311363 SENP6 -0.73 -9.76 -0.47 6.36e-20 Prostate cancer; CRC cis rs1552244 0.572 rs7645667 chr3:10157337 C/A cg18598329 chr3:10140678 FANCD2;C3orf24 -0.9 -10.41 -0.5 3.94e-22 Alzheimer's disease; CRC cis rs6502050 0.805 rs4789721 chr17:80157453 T/C cg19223190 chr17:80058835 NA 0.4 6.52 0.34 2.63e-10 Life satisfaction; CRC cis rs7119 0.717 rs12899390 chr15:77815238 A/C cg27398640 chr15:77910606 LINGO1 -0.44 -7.57 -0.39 3.81e-13 Type 2 diabetes; CRC cis rs8062405 0.754 rs62034323 chr16:28536473 C/T cg16576597 chr16:28551801 NUPR1 0.47 7.34 0.37 1.74e-12 Cognitive ability (multi-trait analysis);Cognitive ability; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg24438655 chr17:45727598 KPNB1 0.41 6.07 0.32 3.45e-9 Intelligence (multi-trait analysis); CRC cis rs208520 0.955 rs9453664 chr6:66976079 A/C cg07460842 chr6:66804631 NA 0.88 10.88 0.51 9.53e-24 Exhaled nitric oxide output; CRC cis rs172166 0.637 rs1233691 chr6:28153897 T/G cg23161317 chr6:28129485 ZNF389 0.46 6.61 0.34 1.52e-10 Cardiac Troponin-T levels; CRC cis rs60871478 0.679 rs4076965 chr7:793272 A/G cg13798912 chr7:905769 UNC84A 0.57 6.13 0.32 2.48e-9 Cerebrospinal P-tau181p levels; CRC cis rs7618501 0.521 rs2352984 chr3:49948728 T/C cg24110177 chr3:50126178 RBM5 -0.6 -9.32 -0.46 1.76e-18 Intelligence (multi-trait analysis); CRC cis rs9443645 0.901 rs1354832 chr6:79613763 A/G cg05283184 chr6:79620031 NA 0.59 9.31 0.46 1.84e-18 Intelligence (multi-trait analysis); CRC cis rs11792861 0.888 rs57314245 chr9:111813832 G/A cg05043794 chr9:111880884 C9orf5 -0.33 -6.14 -0.32 2.35e-9 Menarche (age at onset); CRC cis rs9372498 0.536 rs1319987 chr6:118782236 A/G cg07617317 chr6:118971624 C6orf204 0.52 6.4 0.33 5.29e-10 Diastolic blood pressure; CRC cis rs694739 0.595 rs11606015 chr11:64136877 C/G cg23796481 chr11:64053134 BAD;GPR137 0.49 6.92 0.36 2.33e-11 Alopecia areata;Crohn's disease;Psoriasis vulgaris; CRC cis rs9467711 0.606 rs12173854 chr6:26371679 A/G cg14345882 chr6:26364793 BTN3A2 0.65 5.73 0.3 2.32e-8 Autism spectrum disorder or schizophrenia; CRC cis rs12893668 0.514 rs3212090 chr14:104168863 C/T cg24130564 chr14:104152367 KLC1 -0.43 -5.73 -0.3 2.32e-8 Reticulocyte count; CRC cis rs2760061 0.583 rs708123 chr1:228220495 A/G cg02753203 chr1:228287806 NA 0.99 16.28 0.67 4.1e-44 Diastolic blood pressure; CRC cis rs4665809 0.838 rs6546780 chr2:26352857 T/C cg27170947 chr2:26402098 FAM59B -0.46 -6.07 -0.32 3.46e-9 Gut microbiome composition (summer); CRC cis rs9322193 0.923 rs2151913 chr6:150130642 C/T cg13206674 chr6:150067644 NUP43 0.56 7.9 0.4 4.25e-14 Lung cancer; CRC cis rs561341 0.831 rs11658469 chr17:30206426 T/C cg12193833 chr17:30244370 NA 0.55 6.82 0.35 4.32e-11 Hip circumference adjusted for BMI; CRC cis rs2243480 1.000 rs35283677 chr7:65359233 C/T cg18252515 chr7:66147081 NA -1.17 -13.25 -0.59 2.03e-32 Diabetic kidney disease; CRC cis rs6502050 0.835 rs8065565 chr17:80115399 A/G cg22110888 chr17:80059540 CCDC57 0.4 6.48 0.34 3.37e-10 Life satisfaction; CRC cis rs243505 0.726 rs734005 chr7:148505864 G/A cg09806900 chr7:148480153 CUL1 0.51 7.34 0.37 1.74e-12 Inflammatory bowel disease;Crohn's disease; CRC cis rs7091068 0.754 rs6583903 chr10:95422174 T/C cg20715218 chr10:95462985 C10orf4 0.5 5.94 0.31 7.22e-9 Urinary tract infection frequency; CRC cis rs6951245 0.554 rs58210047 chr7:1149381 G/A cg04025307 chr7:1156635 C7orf50 0.71 8.88 0.44 4.51e-17 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs12410462 0.681 rs58496521 chr1:227582375 T/C cg04117972 chr1:227635322 NA 0.59 5.95 0.31 6.95e-9 Major depressive disorder; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg20002729 chr12:110318525 GLTP 0.44 6.18 0.32 1.87e-9 Anxiety disorder; CRC cis rs2839186 0.619 rs55689527 chr21:47622727 A/G cg13126279 chr21:47581558 C21orf56 -0.39 -6.17 -0.32 1.99e-9 Testicular germ cell tumor; CRC cis rs9903692 0.909 rs1468270 chr17:46125191 C/T cg21215337 chr17:46176117 CBX1 0.43 7.8 0.4 8.28e-14 Pulse pressure; CRC cis rs2730245 0.527 rs2527187 chr7:158716912 T/C cg24397884 chr7:158709396 WDR60 -0.96 -12.13 -0.56 2.99e-28 Height; CRC cis rs11711311 0.747 rs7638378 chr3:113343630 T/A cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.53 -6.99 -0.36 1.56e-11 IgG glycosylation; CRC cis rs6570726 0.791 rs9497357 chr6:145912888 G/A cg05347473 chr6:146136440 FBXO30 0.39 5.87 0.31 1.04e-8 Lobe attachment (rater-scored or self-reported); CRC cis rs35306767 0.623 rs34034003 chr10:1143435 G/A cg20503657 chr10:835505 NA 0.69 8.16 0.41 7.33e-15 Eosinophil percentage of granulocytes; CRC cis rs13031619 0.607 rs13001751 chr2:3695870 A/G cg19052272 chr2:3704530 ALLC -0.44 -6.44 -0.33 4.15e-10 Response to inhaled corticosteroid treatment in asthma (change in FEV1); CRC cis rs7811142 0.887 rs35111986 chr7:100000274 C/A cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.59 7.34 0.38 1.68e-12 Platelet count; CRC cis rs9322193 0.962 rs1889473 chr6:150146621 C/G cg07701084 chr6:150067640 NUP43 0.46 6.49 0.34 3.22e-10 Lung cancer; CRC cis rs6089584 0.888 rs6089624 chr20:60619907 C/G cg13770153 chr20:60521292 NA -0.58 -8.77 -0.44 9.45e-17 Body mass index; CRC cis rs734999 0.588 rs6668149 chr1:2558308 A/C cg18854424 chr1:2615690 NA -0.39 -7.32 -0.37 1.91e-12 Ulcerative colitis; CRC cis rs10760158 0.832 rs4240466 chr9:124039734 A/T cg14417974 chr9:124058376 GSN -0.33 -5.64 -0.3 3.71e-8 Pulse pressure; CRC cis rs10991814 0.920 rs7857020 chr9:94035272 G/T cg14446406 chr9:93919335 NA 0.58 6.41 0.33 5.03e-10 Neutrophil percentage of granulocytes; CRC cis rs7666738 0.830 rs115279324 chr4:99042114 T/C cg17366294 chr4:99064904 C4orf37 0.44 7.39 0.38 1.25e-12 Colonoscopy-negative controls vs population controls; CRC cis rs2857891 1.000 rs1388527 chr11:6948441 C/T cg14883916 chr11:6947541 ZNF215 0.63 6.87 0.35 3.29e-11 Response to cytadine analogues (cytosine arabinoside); CRC cis rs1218582 0.651 rs4845396 chr1:154828409 A/G cg16680214 chr1:154839983 KCNN3 0.37 6.64 0.34 1.29e-10 Prostate cancer; CRC cis rs7666738 0.830 rs17483521 chr4:98974058 A/T cg17366294 chr4:99064904 C4orf37 0.44 7.37 0.38 1.43e-12 Colonoscopy-negative controls vs population controls; CRC trans rs66887589 0.627 rs3872807 chr4:120360251 T/A cg25214090 chr10:38739885 LOC399744 0.43 6.7 0.35 9.29e-11 Diastolic blood pressure; CRC cis rs4604732 0.631 rs74154676 chr1:247625894 T/C cg12758973 chr1:247694275 LOC148824;OR2C3 0.42 6.14 0.32 2.32e-9 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CRC cis rs8180040 0.934 rs4858811 chr3:47480524 G/C cg02527881 chr3:46936655 PTH1R 0.37 6.83 0.35 4.11e-11 Colorectal cancer; CRC cis rs7804356 1.000 rs6461980 chr7:26894123 T/G cg03456212 chr7:26904342 SKAP2 -0.49 -5.62 -0.3 4.06e-8 Type 1 diabetes; CRC cis rs4474465 0.850 rs10793323 chr11:78244170 C/T cg02023728 chr11:77925099 USP35 -0.36 -6.07 -0.32 3.46e-9 Alzheimer's disease (survival time); CRC cis rs7020830 0.931 rs7027473 chr9:37132462 A/G cg14294708 chr9:37120828 ZCCHC7 1.21 28.58 0.84 3.59e-91 Schizophrenia; CRC cis rs4713118 0.869 rs6902689 chr6:27709441 C/T cg20933634 chr6:27740509 NA 0.57 8.29 0.42 2.86e-15 Parkinson's disease; CRC cis rs600231 0.708 rs2957268 chr11:65245816 A/G cg17120908 chr11:65337727 SSSCA1 -0.56 -8.34 -0.42 2.03e-15 Bone mineral density; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg15693898 chr3:183602556 PARL 0.41 6.07 0.32 3.6e-9 Intelligence (multi-trait analysis); CRC cis rs870825 0.616 rs7654208 chr4:185648877 C/T cg04058563 chr4:185651563 MLF1IP 0.72 9.3 0.46 2.04e-18 Blood protein levels; CRC cis rs3820068 0.581 rs2861387 chr1:15951296 G/A cg24675056 chr1:15929824 NA 0.51 7.03 0.36 1.19e-11 Systolic blood pressure; CRC cis rs7208859 0.673 rs9915139 chr17:29158515 A/G cg01831904 chr17:28903510 LRRC37B2 -0.55 -6.0 -0.31 5.15e-9 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs1799949 0.930 rs56729776 chr17:41422131 C/T cg01879757 chr17:41196368 BRCA1 -0.41 -6.05 -0.32 4.03e-9 Menopause (age at onset); CRC cis rs2070677 0.935 rs12255182 chr10:135404096 G/A cg16964102 chr10:135390573 NA 0.49 6.63 0.34 1.38e-10 Gout; CRC cis rs6582630 0.533 rs2120464 chr12:38280289 A/C cg26384229 chr12:38710491 ALG10B 0.52 7.59 0.39 3.32e-13 Drug-induced liver injury (flucloxacillin); CRC cis rs6662572 1.000 rs28584711 chr1:46212631 C/T cg08644498 chr1:46502608 NA 0.45 6.31 0.33 8.91e-10 Blood protein levels; CRC trans rs6550704 0.687 rs9865314 chr3:22634337 A/G cg21365899 chr1:231558446 EGLN1 -0.41 -6.2 -0.32 1.69e-9 Daytime sleep phenotypes; CRC cis rs7107174 1.000 rs2510047 chr11:77988668 C/T cg02023728 chr11:77925099 USP35 -0.48 -8.3 -0.42 2.73e-15 Testicular germ cell tumor; CRC cis rs11083475 0.686 rs73040728 chr19:39257601 C/G cg26703956 chr19:39260304 NA -0.37 -5.96 -0.31 6.65e-9 Heart rate; CRC cis rs13191362 0.688 rs73035006 chr6:162997083 G/T cg21926612 chr6:163149169 PACRG;PARK2 0.8 11.25 0.53 4.59e-25 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs3806843 0.966 rs2337986 chr5:140160622 C/T cg19875535 chr5:140030758 IK 0.6 9.79 0.47 5.14e-20 Depressive symptoms (multi-trait analysis); CRC cis rs172166 0.652 rs476167 chr6:28065888 T/C cg20615401 chr6:28092323 ZSCAN16 0.45 5.98 0.31 5.68e-9 Cardiac Troponin-T levels; CRC cis rs7412746 0.658 rs12068264 chr1:150727329 C/T cg15448220 chr1:150897856 SETDB1 0.54 7.59 0.39 3.34e-13 Melanoma; CRC cis rs17767392 0.914 rs10139519 chr14:72109270 C/A cg13720639 chr14:72061746 SIPA1L1 0.56 7.04 0.36 1.15e-11 Mitral valve prolapse; CRC cis rs9435341 0.965 rs55924375 chr1:107566690 C/A cg09367891 chr1:107599246 PRMT6 0.66 10.04 0.48 7.39e-21 Facial morphology (factor 21, depth of nasal alae); CRC cis rs12325245 0.536 rs34676074 chr16:58549321 G/C cg05725404 chr16:58534157 NDRG4 -0.6 -5.6 -0.3 4.45e-8 Schizophrenia; CRC trans rs12478296 0.892 rs11897561 chr2:243014976 C/A cg06834434 chr14:75079333 LTBP2 0.51 6.08 0.32 3.39e-9 Obesity-related traits; CRC cis rs4400599 0.805 rs10908739 chr1:154160655 T/C cg05139571 chr1:154127138 NUP210L 0.44 6.62 0.34 1.43e-10 Platelet distribution width; CRC cis rs7493 1.000 rs6968305 chr7:95042529 G/A cg19678392 chr7:94953810 PON1 -0.56 -7.03 -0.36 1.18e-11 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs6921919 0.583 rs1361385 chr6:28358320 A/G cg21251018 chr6:28226885 NKAPL 0.41 6.24 0.33 1.35e-9 Autism spectrum disorder or schizophrenia; CRC cis rs11763147 1 rs11763147 chr7:65326821 C/T cg00343986 chr7:65444356 GUSB -0.55 -8.54 -0.43 5.11e-16 Corneal structure; CRC cis rs4474465 0.920 rs10899529 chr11:78207848 T/C cg27205649 chr11:78285834 NARS2 0.47 5.79 0.3 1.61e-8 Alzheimer's disease (survival time); CRC cis rs9837602 1.000 rs4571265 chr3:99705111 A/G cg07805332 chr3:99536008 MIR548G;C3orf26 0.47 6.2 0.32 1.65e-9 Breast cancer; CRC cis rs8062405 0.755 rs17640009 chr16:28595700 A/G cg16576597 chr16:28551801 NUPR1 0.53 7.82 0.4 7.01e-14 Cognitive ability (multi-trait analysis);Cognitive ability; CRC trans rs71327718 1 rs71327718 chr3:125592857 C/G cg07211511 chr3:129823064 LOC729375 -1.08 -12.52 -0.57 1.16e-29 Metabolite levels (HVA/5-HIAA ratio); CRC cis rs4363385 0.818 rs370162 chr1:153005488 G/A cg25856811 chr1:152973957 SPRR3 -0.25 -6.99 -0.36 1.51e-11 Inflammatory skin disease; CRC trans rs561341 0.941 rs72825746 chr17:30364610 G/A cg27661571 chr11:113659931 NA -0.95 -11.1 -0.52 1.64e-24 Hip circumference adjusted for BMI; CRC cis rs4481887 1.000 rs4409693 chr1:248479061 C/T cg00666640 chr1:248458726 OR2T12 0.55 9.52 0.46 3.85e-19 Common traits (Other); CRC cis rs9549328 0.800 rs9549326 chr13:113630453 C/T cg16822035 chr13:113633379 MCF2L -0.29 -5.91 -0.31 8.41e-9 Systolic blood pressure; CRC cis rs2204008 0.837 rs34381557 chr12:38181983 T/C cg13010199 chr12:38710504 ALG10B 0.45 5.74 0.3 2.1e-8 Bladder cancer; CRC cis rs185694 0.779 rs639234 chr13:30893984 G/A cg07600127 chr13:30881527 KATNAL1 -0.51 -5.61 -0.3 4.21e-8 Antineutrophil cytoplasmic antibody-associated vasculitis; CRC cis rs919433 0.963 rs4850429 chr2:198178409 A/G cg10820045 chr2:198174542 NA 0.54 9.54 0.47 3.29e-19 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC cis rs875971 0.545 rs10950027 chr7:65634151 C/T cg18876405 chr7:65276391 NA 0.46 6.46 0.34 3.7e-10 Aortic root size; CRC cis rs950776 0.518 rs12903129 chr15:78819606 C/T cg06917634 chr15:78832804 PSMA4 0.66 10.37 0.5 5.36e-22 Sudden cardiac arrest; CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg22024508 chr19:16771032 TMEM38A;C19orf42 -0.5 -6.0 -0.31 5.13e-9 Diisocyanate-induced asthma; CRC cis rs7223966 1.000 rs113134232 chr17:61715461 G/A cg23090583 chr17:61904693 PSMC5;FTSJ3 0.57 6.47 0.34 3.46e-10 Hip circumference adjusted for BMI;Body mass index; CRC cis rs10426930 0.700 rs10413045 chr19:5024099 G/T cg25246084 chr19:4971487 KDM4B -0.34 -5.76 -0.3 1.9e-8 Monocyte percentage of white cells; CRC cis rs1552244 0.510 rs13075308 chr3:10034925 G/C cg00166722 chr3:10149974 C3orf24 0.61 8.0 0.4 2.17e-14 Alzheimer's disease; CRC trans rs3743266 0.613 rs2414669 chr15:60708824 A/G cg18663513 chr1:53793486 LRP8 0.39 5.98 0.31 5.82e-9 Menarche (age at onset); CRC cis rs2070677 0.877 rs8192777 chr10:135350871 G/T cg16964102 chr10:135390573 NA -0.5 -6.94 -0.36 2.16e-11 Gout; CRC cis rs4862750 0.872 rs4862748 chr4:187877388 C/T cg03452623 chr4:187889614 NA 0.82 15.03 0.64 3.17e-39 Lobe attachment (rater-scored or self-reported); CRC cis rs10504229 0.516 rs58244172 chr8:57987805 G/A cg02725872 chr8:58115012 NA -0.32 -5.72 -0.3 2.39e-8 Developmental language disorder (linguistic errors); CRC cis rs10504229 0.683 rs55637580 chr8:58135419 C/T cg22535103 chr8:58192502 C8orf71 -0.7 -9.34 -0.46 1.47e-18 Developmental language disorder (linguistic errors); CRC cis rs1519814 1.000 rs4504680 chr8:121132175 T/C cg22335954 chr8:121166405 COL14A1 -0.56 -6.3 -0.33 9.33e-10 Breast cancer; CRC cis rs929354 0.713 rs6459733 chr7:156930550 G/C cg16102536 chr7:156981717 UBE3C 0.42 6.88 0.35 3.12e-11 Body mass index; CRC trans rs783540 1.000 rs7496954 chr15:83345536 T/G cg18393722 chr15:85113863 UBE2QP1 0.35 5.97 0.31 6.08e-9 Schizophrenia; CRC cis rs67311347 0.544 rs12635762 chr3:40332759 C/T cg09455208 chr3:40491958 NA -0.33 -6.78 -0.35 5.48e-11 Renal cell carcinoma; CRC trans rs10506458 0.834 rs12426893 chr12:63388120 G/T cg22491629 chr6:157744540 C6orf35 -0.73 -8.35 -0.42 1.9e-15 Hemostatic factors and hematological phenotypes; CRC cis rs6502050 0.626 rs11868521 chr17:80100195 T/G cg13198984 chr17:80129470 CCDC57 -0.37 -6.17 -0.32 2.05e-9 Life satisfaction; CRC cis rs7584330 0.704 rs7598954 chr2:238364776 C/T cg14458575 chr2:238380390 NA 0.9 16.44 0.67 9.63e-45 Prostate cancer; CRC cis rs8180040 0.932 rs12489046 chr3:47527683 T/G cg02527881 chr3:46936655 PTH1R -0.41 -7.84 -0.4 6.52e-14 Colorectal cancer; CRC cis rs10876993 0.784 rs7314152 chr12:58017701 T/G cg18357645 chr12:58087776 OS9 -0.5 -6.75 -0.35 6.63e-11 Celiac disease or Rheumatoid arthritis; CRC cis rs17095355 0.579 rs72828224 chr10:111702047 A/G cg00817464 chr10:111662876 XPNPEP1 -0.6 -8.11 -0.41 1.04e-14 Biliary atresia; CRC cis rs2180341 0.597 rs3798859 chr6:127663116 C/T cg24812749 chr6:127587940 RNF146 0.64 9.58 0.47 2.37e-19 Breast cancer; CRC cis rs1474256 0.630 rs79015977 chr15:79450147 G/A cg17916960 chr15:79447300 NA 0.42 5.64 0.3 3.67e-8 Bronchopulmonary dysplasia; CRC cis rs4555082 0.874 rs2816611 chr14:105722976 G/C cg10792982 chr14:105748885 BRF1 0.37 6.19 0.32 1.75e-9 Mean platelet volume;Platelet distribution width; CRC cis rs4803480 1.000 rs7255679 chr19:42063981 G/T cg08478046 chr19:42093086 CEACAM21 -0.34 -6.08 -0.32 3.34e-9 Schizophrenia; CRC cis rs1552244 0.515 rs111560858 chr3:10166845 G/A cg18598329 chr3:10140678 FANCD2;C3orf24 -0.91 -10.88 -0.51 9.24e-24 Alzheimer's disease; CRC cis rs1008375 1.000 rs1121091 chr4:17676386 A/C cg04450456 chr4:17643702 FAM184B 0.39 6.22 0.32 1.53e-9 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs782590 0.807 rs782642 chr2:55928444 G/T cg18811423 chr2:55921094 PNPT1 0.88 16.83 0.68 2.64e-46 Metabolic syndrome; CRC cis rs7447927 0.950 rs13181561 chr5:138850905 A/G cg11459648 chr5:138714337 SLC23A1 -0.36 -5.69 -0.3 2.8e-8 Esophageal squamous cell carcinoma; CRC cis rs738322 1.000 rs738320 chr22:38568715 G/T cg25457927 chr22:38595422 NA -0.35 -7.38 -0.38 1.29e-12 Cutaneous nevi; CRC cis rs2839186 0.605 rs2839174 chr21:47676934 T/C cg09417038 chr21:47716443 C21orf57 -0.39 -6.37 -0.33 6.55e-10 Testicular germ cell tumor; CRC cis rs2692947 0.616 rs2301707 chr2:96931846 T/C cg23100626 chr2:96804247 ASTL 0.3 7.63 0.39 2.55e-13 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; CRC cis rs7772486 0.790 rs2814879 chr6:146201743 T/C cg13319975 chr6:146136371 FBXO30 -0.42 -6.36 -0.33 6.7e-10 Lobe attachment (rater-scored or self-reported); CRC cis rs6586163 0.872 rs1926197 chr10:90748626 A/G cg13456138 chr10:90753195 FAS -0.44 -6.61 -0.34 1.54e-10 Chronic lymphocytic leukemia; CRC cis rs7224685 0.906 rs2278524 chr17:4081975 A/G cg11204139 chr17:3907470 NA -0.43 -6.32 -0.33 8.35e-10 Type 2 diabetes; CRC cis rs10097731 0.908 rs77317991 chr8:82032468 C/T cg25230327 chr8:82042993 NA -0.78 -11.22 -0.53 5.85e-25 Serum total protein level; CRC cis rs6951245 0.882 rs10256720 chr7:1210825 C/G cg24642844 chr7:1081250 C7orf50 -0.68 -8.29 -0.42 2.95e-15 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs17376456 0.877 rs10072592 chr5:93405989 C/G cg25358565 chr5:93447407 FAM172A 1.02 10.31 0.49 8.6e-22 Diabetic retinopathy; CRC cis rs2019137 0.560 rs4849179 chr2:113985170 C/T cg23564664 chr2:113997917 PAX8;LOC654433;LOC440839 -0.36 -5.93 -0.31 7.84e-9 Lymphocyte counts; CRC cis rs11168351 1.000 rs11168351 chr12:48403765 C/T cg15465823 chr12:48382534 COL2A1 0.37 6.05 0.32 3.94e-9 Bipolar disorder and schizophrenia; CRC cis rs6459804 1.000 rs58278053 chr7:157512934 A/T cg05731713 chr7:157510257 PTPRN2 0.47 7.97 0.4 2.63e-14 Bipolar disorder and schizophrenia; CRC cis rs568617 0.767 rs2231884 chr11:65656564 C/T cg19792802 chr11:65647270 CTSW 0.62 7.41 0.38 1.09e-12 Crohn's disease; CRC cis rs12410462 0.681 rs75876430 chr1:227661157 A/G cg04117972 chr1:227635322 NA 0.83 8.33 0.42 2.26e-15 Major depressive disorder; CRC cis rs7072216 0.770 rs7896828 chr10:100170507 A/T cg26618903 chr10:100175079 PYROXD2 -0.4 -6.74 -0.35 6.96e-11 Metabolite levels; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg20180059 chr1:109584182 WDR47 0.45 6.4 0.33 5.32e-10 Response to antipsychotic treatment; CRC trans rs10842750 1.000 rs10842750 chr12:26690565 G/T cg26710055 chr3:15468825 EAF1;METTL6 0.51 6.33 0.33 8.21e-10 Kashin-Beck disease; CRC cis rs877282 0.891 rs10904557 chr10:797490 C/T cg17470449 chr10:769945 NA -0.63 -8.51 -0.42 6.42e-16 Uric acid levels; CRC trans rs2565722 0.622 rs2489944 chr6:161292913 C/T cg01698392 chr17:76871734 TIMP2 -0.46 -6.06 -0.32 3.66e-9 Blood protein levels; CRC cis rs1030268 1.000 rs1030268 chr7:133606631 C/T cg03336402 chr7:133662267 EXOC4 0.58 7.71 0.39 1.47e-13 Intelligence (multi-trait analysis); CRC trans rs1005277 0.540 rs2145487 chr10:38010077 A/G cg17830980 chr10:43048298 ZNF37B -0.4 -6.24 -0.33 1.36e-9 Extrinsic epigenetic age acceleration; CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg10815483 chr17:16394899 C17orf76 -0.54 -6.78 -0.35 5.48e-11 Diisocyanate-induced asthma; CRC cis rs9381040 1.000 rs2093395 chr6:41155026 C/G cg03644281 chr6:41068752 NFYA;LOC221442 0.47 6.44 0.33 4.28e-10 Alzheimer's disease (late onset); CRC cis rs6500602 0.701 rs4785971 chr16:4577090 A/G cg14951292 chr16:4525986 HMOX2;NMRAL1 0.76 10.77 0.51 2.19e-23 Schizophrenia; CRC cis rs4713118 0.515 rs9368549 chr6:28050047 T/A cg25164649 chr6:28176230 NA 0.73 9.32 0.46 1.74e-18 Parkinson's disease; CRC cis rs798554 0.634 rs1182180 chr7:2873279 G/T cg19717773 chr7:2847554 GNA12 -0.44 -7.47 -0.38 7.28e-13 Height; CRC cis rs7659604 0.521 rs4833234 chr4:122694799 T/C cg19748678 chr4:122722346 EXOSC9 -0.45 -6.14 -0.32 2.35e-9 Type 2 diabetes; CRC cis rs9399135 0.967 rs9376085 chr6:135371224 T/C cg24558204 chr6:135376177 HBS1L 0.49 7.72 0.39 1.41e-13 Red blood cell count; CRC cis rs372883 0.901 rs733610 chr21:30656199 G/A cg08807101 chr21:30365312 RNF160 -0.38 -5.61 -0.3 4.32e-8 Pancreatic cancer; CRC cis rs35110281 0.667 rs4819285 chr21:45118970 C/T cg01579765 chr21:45077557 HSF2BP 0.32 6.07 0.32 3.58e-9 Mean corpuscular volume; CRC cis rs6952808 0.689 rs871924 chr7:2047845 A/G cg00106254 chr7:1943704 MAD1L1 -0.47 -7.02 -0.36 1.24e-11 Bipolar disorder and schizophrenia; CRC cis rs9682041 0.660 rs13089074 chr3:170113481 G/A cg11886554 chr3:170076028 SKIL 0.7 8.33 0.42 2.21e-15 Glomerular filtration rate in non diabetics (creatinine);Glomerular filtration rate (creatinine); CRC trans rs7726839 0.574 rs11739866 chr5:636299 C/T cg11887960 chr12:57824829 NA 0.59 6.57 0.34 2e-10 Obesity-related traits; CRC cis rs875971 0.964 rs9691480 chr7:65944306 A/C cg18912574 chr7:65842487 NCRNA00174 0.36 6.1 0.32 2.97e-9 Aortic root size; CRC cis rs6484504 0.576 rs286653 chr11:31227824 C/T cg14844989 chr11:31128820 NA -0.34 -5.98 -0.31 5.89e-9 Red blood cell count; CRC cis rs853679 0.517 rs9393897 chr6:28127710 G/T cg21251018 chr6:28226885 NKAPL 0.48 6.17 0.32 2.02e-9 Depression; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg18305333 chr11:62439274 C11orf83;C11orf48 0.47 6.66 0.34 1.13e-10 Response to antipsychotic treatment; CRC cis rs4713118 0.869 rs9393851 chr6:27699581 A/T cg12273811 chr6:28175739 NA 0.53 7.64 0.39 2.4e-13 Parkinson's disease; CRC cis rs2070488 0.965 rs7642472 chr3:38525567 T/C cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.92 17.31 0.69 3.51e-48 Electrocardiographic conduction measures; CRC trans rs9329221 0.506 rs17689674 chr8:9981854 C/A cg06636001 chr8:8085503 FLJ10661 0.46 6.77 0.35 5.95e-11 Neuroticism; CRC cis rs6456156 0.586 rs12203510 chr6:167473006 C/T cg07741184 chr6:167504864 NA 0.39 6.92 0.36 2.42e-11 Primary biliary cholangitis; CRC cis rs2346177 0.519 rs4563285 chr2:46669944 C/G cg02822958 chr2:46747628 ATP6V1E2 0.41 5.96 0.31 6.41e-9 HDL cholesterol; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg11970843 chr2:203736525 ICA1L 0.39 6.14 0.32 2.44e-9 Intelligence (multi-trait analysis); CRC trans rs2018683 0.707 rs4719961 chr7:28969513 C/T cg19402173 chr7:128379420 CALU -0.43 -6.23 -0.32 1.44e-9 Response to irinotecan and platinum-based chemotherapy in non-small-cell lung cancer; CRC cis rs853679 0.517 rs4713145 chr6:28106827 T/C cg15845792 chr6:28175446 NA 1.01 13.54 0.6 1.59e-33 Depression; CRC cis rs4253772 0.591 rs6007732 chr22:46652303 A/T cg24881330 chr22:46731750 TRMU 0.54 6.28 0.33 1.07e-9 LDL cholesterol;Cholesterol, total; CRC cis rs524281 0.861 rs4013917 chr11:65926185 A/G cg14036092 chr11:66035641 RAB1B -0.47 -5.71 -0.3 2.54e-8 Electroencephalogram traits; CRC cis rs4148883 0.689 rs2602861 chr4:100030896 C/T cg12011299 chr4:100065546 ADH4 0.54 11.96 0.55 1.3e-27 Alcohol dependence; CRC cis rs7212938 0.509 rs62068170 chr17:38103210 G/A cg24910161 chr17:38119198 GSDMA -0.42 -7.45 -0.38 8.14e-13 Asthma and hay fever; CRC trans rs12912251 1.000 rs2132157 chr15:38992547 A/G cg24952240 chr4:169567560 PALLD -0.4 -5.97 -0.31 6.28e-9 Bipolar disorder;Bipolar disorder or major depressive disorder (combined); CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg01301935 chr16:69599904 NFAT5;MIR1538 0.49 6.4 0.33 5.42e-10 Anxiety disorder; CRC cis rs4713118 0.539 rs200988 chr6:27819353 A/C cg23161317 chr6:28129485 ZNF389 0.43 6.05 0.32 3.88e-9 Parkinson's disease; CRC cis rs908922 0.676 rs945789 chr1:152512705 C/A cg09873164 chr1:152488093 CRCT1 0.38 6.4 0.33 5.37e-10 Hair morphology; CRC cis rs17270561 0.609 rs4464787 chr6:25733558 G/C cg17691542 chr6:26056736 HIST1H1C 0.74 9.37 0.46 1.19e-18 Iron status biomarkers; CRC trans rs57221529 0.766 rs12521988 chr5:556421 C/T cg25482853 chr8:67687455 SGK3 1.25 15.72 0.65 6.58e-42 Lung disease severity in cystic fibrosis; CRC cis rs514406 0.570 rs1332776 chr1:53189816 C/T cg08859206 chr1:53392774 SCP2 -0.45 -7.08 -0.36 8.9e-12 Monocyte count; CRC cis rs8105895 0.935 rs2043315 chr19:22252823 T/C cg02657401 chr19:22469223 NA -0.34 -5.65 -0.3 3.56e-8 Body mass index (change over time); CRC cis rs798554 0.686 rs2527690 chr7:2854250 C/T cg17321639 chr7:2759063 NA -0.4 -6.09 -0.32 3.18e-9 Height; CRC cis rs10992471 0.603 rs10114932 chr9:95307901 C/A cg14631576 chr9:95140430 CENPP -0.38 -6.59 -0.34 1.75e-10 Visceral adipose tissue/subcutaneous adipose tissue ratio; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg16120927 chr11:63536330 C11orf95 0.48 6.8 0.35 4.9e-11 Response to antipsychotic treatment; CRC cis rs2404602 0.692 rs12595586 chr15:77172210 A/G cg22467129 chr15:76604101 ETFA -0.38 -6.07 -0.32 3.61e-9 Blood metabolite levels; CRC cis rs34172651 0.687 rs8044992 chr16:24811207 T/C cg00339695 chr16:24857497 SLC5A11 0.26 5.9 0.31 9.12e-9 Intelligence (multi-trait analysis); CRC cis rs1997103 1.000 rs10252413 chr7:55396740 C/G cg17469321 chr7:55412551 NA 0.74 11.31 0.53 2.8e-25 QRS interval (sulfonylurea treatment interaction); CRC trans rs7395662 0.713 rs11512404 chr11:48936171 T/G cg21153622 chr11:89784906 NA -0.47 -7.42 -0.38 9.85e-13 HDL cholesterol; CRC cis rs11212617 0.869 rs12801988 chr11:108357747 C/T cg12106634 chr11:108092400 ATM;NPAT -0.39 -5.63 -0.3 3.86e-8 Response to metformin in type 2 diabetes (glycemic); CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg00006032 chr14:66974439 GPHN -0.53 -6.5 -0.34 2.91e-10 Diisocyanate-induced asthma; CRC trans rs7395662 0.611 rs4882089 chr11:48515612 A/T cg21153622 chr11:89784906 NA -0.51 -8.55 -0.43 4.82e-16 HDL cholesterol; CRC cis rs2075371 1.000 rs2504 chr7:133979545 A/T cg02659138 chr7:134003124 SLC35B4 0.4 6.94 0.36 2.16e-11 Mean platelet volume; CRC trans rs2727020 0.576 rs10839305 chr11:49598733 T/C cg03929089 chr4:120376271 NA -0.91 -17.25 -0.69 6.27e-48 Coronary artery disease; CRC cis rs28386778 0.830 rs2597636 chr17:61876010 A/G cg06601766 chr17:61851465 DDX42;CCDC47 0.45 6.14 0.32 2.4e-9 Prudent dietary pattern; CRC cis rs4843747 0.671 rs28451517 chr16:88109127 A/C cg17633681 chr16:88106987 BANP 0.85 14.64 0.63 1.05e-37 Menopause (age at onset); CRC cis rs7635838 0.819 rs4684072 chr3:11514860 A/G cg00170343 chr3:11313890 ATG7 0.43 6.54 0.34 2.38e-10 HDL cholesterol; CRC cis rs6762 0.550 rs8672 chr11:838634 C/G cg16425592 chr11:842748 TSPAN4;POLR2L -0.54 -7.95 -0.4 2.94e-14 Mean platelet volume; CRC cis rs9818758 0.607 rs35673421 chr3:49139406 G/A cg00383909 chr3:49044727 WDR6 1.26 12.25 0.56 1.14e-28 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; CRC cis rs875971 0.522 rs1617484 chr7:65463095 G/A cg00343986 chr7:65444356 GUSB 0.52 7.75 0.39 1.15e-13 Aortic root size; CRC cis rs2522056 0.935 rs1981524 chr5:131756506 C/T cg20512303 chr5:131592959 PDLIM4 -0.36 -5.63 -0.3 3.85e-8 Lymphocyte counts;Fibrinogen; CRC cis rs7968440 0.651 rs7309519 chr12:50652280 G/A cg12020201 chr12:50017283 PRPF40B 0.35 5.78 0.3 1.71e-8 Fibrinogen; CRC cis rs8014204 0.762 rs2359237 chr14:75245002 G/A cg03030879 chr14:75389066 RPS6KL1 -0.4 -6.31 -0.33 9.21e-10 Caffeine consumption; CRC cis rs425277 0.628 rs10797427 chr1:2060732 C/T cg04315214 chr1:2043799 PRKCZ 0.48 8.73 0.43 1.31e-16 Height; CRC trans rs2303319 0.504 rs1006427 chr2:162592328 T/C cg10498984 chr16:28874827 SH2B1 -0.73 -6.3 -0.33 9.75e-10 Cognitive function; CRC cis rs6121246 0.522 rs6088736 chr20:30195166 C/G cg13852791 chr20:30311386 BCL2L1 0.6 8.21 0.41 5.04e-15 Mean corpuscular hemoglobin; CRC trans rs7647973 0.588 rs9883000 chr3:49667691 A/G cg21659725 chr3:3221576 CRBN -0.64 -6.92 -0.36 2.33e-11 Menarche (age at onset); CRC cis rs2354432 0.607 rs1890039 chr1:146681951 T/C cg25205988 chr1:146714368 CHD1L 1.07 9.25 0.45 2.99e-18 Mitochondrial DNA levels; CRC cis rs10876993 0.890 rs1689584 chr12:58081478 G/A cg15848620 chr12:58087721 OS9 -0.65 -9.09 -0.45 9.71e-18 Celiac disease or Rheumatoid arthritis; CRC cis rs1153858 1.000 rs7169587 chr15:45640379 A/G cg21132104 chr15:45694354 SPATA5L1 0.58 8.67 0.43 1.98e-16 Homoarginine levels; CRC cis rs644799 1.000 rs10831431 chr11:95510089 C/T cg25622487 chr11:95524042 FAM76B;CEP57 0.76 11.68 0.54 1.28e-26 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs1401999 1.000 rs6767013 chr3:183680102 G/A cg01324343 chr3:183735012 ABCC5 0.8 14.51 0.62 3.2e-37 Anterior chamber depth; CRC cis rs13217239 0.646 rs12527111 chr6:27006475 C/T cg05192639 chr6:26864778 GUSBL1 0.3 5.78 0.3 1.74e-8 Schizophrenia; CRC cis rs11098499 0.863 rs10004484 chr4:120442428 C/T cg24375607 chr4:120327624 NA 0.47 7.18 0.37 4.66e-12 Corneal astigmatism; CRC trans rs1005277 0.579 rs2472183 chr10:38392495 T/G cg11292332 chr7:45801988 SEPT13 -0.35 -6.26 -0.33 1.18e-9 Extrinsic epigenetic age acceleration; CRC cis rs9291683 0.530 rs998675 chr4:9948829 A/G cg11266682 chr4:10021025 SLC2A9 0.5 9.88 0.48 2.5e-20 Bone mineral density; CRC cis rs7680126 0.596 rs11731652 chr4:10292984 T/C cg00071950 chr4:10020882 SLC2A9 -0.46 -6.04 -0.32 4.23e-9 Urate levels in lean individuals;Urate levels in overweight individuals;Urate levels in obese individuals; CRC cis rs9291683 0.525 rs12506455 chr4:10031569 T/A cg11266682 chr4:10021025 SLC2A9 0.53 11.11 0.52 1.39e-24 Bone mineral density; CRC cis rs7463659 1.000 rs7463659 chr8:135432140 T/C cg09855544 chr8:135498122 ZFAT -0.38 -5.81 -0.3 1.51e-8 Colonoscopy-negative controls vs population controls; CRC cis rs6667605 0.527 rs12046118 chr1:2540343 A/C cg20673091 chr1:2541236 MMEL1 0.36 5.88 0.31 9.88e-9 Inflammatory bowel disease;Ulcerative colitis; CRC cis rs6502050 0.835 rs12938965 chr17:80128646 G/A cg09264619 chr17:80180166 NA -0.34 -5.76 -0.3 1.93e-8 Life satisfaction; CRC cis rs765787 0.505 rs12593605 chr15:45497448 T/A cg24006582 chr15:45444508 DUOX1 0.56 8.02 0.4 1.88e-14 Uric acid levels; CRC cis rs6540559 0.546 rs7551944 chr1:210029430 G/C cg22029157 chr1:209979665 IRF6 0.61 6.72 0.35 8.09e-11 Cleft lip with or without cleft palate; CRC cis rs2153535 0.580 rs9393022 chr6:8466588 T/C cg07606381 chr6:8435919 SLC35B3 0.66 10.68 0.51 4.78e-23 Motion sickness; CRC cis rs274567 0.501 rs272856 chr5:131687081 G/C cg11843238 chr5:131593191 PDLIM4 0.43 6.98 0.36 1.59e-11 Blood metabolite levels; CRC cis rs7312933 0.737 rs10880261 chr12:42573822 T/C cg19980929 chr12:42632907 YAF2 0.45 6.61 0.34 1.59e-10 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg23944232 chr2:86948118 RMND5A 0.4 6.48 0.34 3.37e-10 Liver disease severity in Alagille syndrome; CRC cis rs7605827 0.930 rs1997307 chr2:15512588 T/C cg19274914 chr2:15703543 NA 0.39 6.03 0.32 4.36e-9 Educational attainment (years of education); CRC cis rs17270561 0.609 rs7769908 chr6:25760539 G/A cg16482183 chr6:26056742 HIST1H1C 0.71 9.0 0.44 1.79e-17 Iron status biomarkers; CRC cis rs1401999 0.668 rs6806313 chr3:183642152 G/C cg01324343 chr3:183735012 ABCC5 0.63 10.14 0.49 3.38e-21 Anterior chamber depth; CRC cis rs1008375 0.932 rs10029173 chr4:17659598 C/T cg16339924 chr4:17578868 LAP3 -0.52 -6.8 -0.35 4.97e-11 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs858239 0.932 rs1728313 chr7:23271031 A/C cg00469287 chr7:23338798 C7orf30 0.43 5.78 0.3 1.77e-8 Cerebrospinal fluid biomarker levels; CRC cis rs4629710 0.592 rs13195700 chr6:131585299 C/T cg12606694 chr6:131520996 AKAP7 0.54 8.19 0.41 5.77e-15 Multiple myeloma (IgH translocation); CRC cis rs2762353 0.595 rs12207313 chr6:25741027 G/C cg03264133 chr6:25882463 NA 0.72 10.11 0.49 4.11e-21 Blood metabolite levels; CRC cis rs3733585 0.648 rs13125029 chr4:9982029 A/G cg11266682 chr4:10021025 SLC2A9 0.46 9.22 0.45 3.54e-18 Cleft plate (environmental tobacco smoke interaction); CRC cis rs10450586 0.932 rs10835155 chr11:27317812 C/T cg10370305 chr11:27303972 NA 0.35 5.69 0.3 2.76e-8 Total body bone mineral density; CRC cis rs6951245 0.554 rs2070118 chr7:1132505 G/A cg18297960 chr7:1142765 C7orf50 -0.45 -6.1 -0.32 2.95e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs10504229 0.683 rs7820559 chr8:58142662 C/T cg24829409 chr8:58192753 C8orf71 -0.55 -8.1 -0.41 1.11e-14 Developmental language disorder (linguistic errors); CRC cis rs4713118 0.540 rs469227 chr6:27970705 A/C cg10876282 chr6:28092338 ZSCAN16 0.44 5.88 0.31 9.85e-9 Parkinson's disease; CRC cis rs7586879 1.000 rs11683212 chr2:25120196 T/C cg22495460 chr2:25135724 ADCY3 -0.73 -11.97 -0.55 1.19e-27 Body mass index; CRC cis rs514406 0.825 rs6588441 chr1:53223494 G/A cg08859206 chr1:53392774 SCP2 0.42 6.56 0.34 2.14e-10 Monocyte count; CRC cis rs881375 0.715 rs10760119 chr9:123646060 T/C cg09586646 chr9:123605570 PSMD5;LOC253039 0.4 5.73 0.3 2.3e-8 Rheumatoid arthritis; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg04474326 chr20:57556688 TH1L 0.44 5.97 0.31 6.19e-9 Response to antipsychotic treatment; CRC trans rs1814175 0.715 rs10839409 chr11:49884647 G/T cg15704280 chr7:45808275 SEPT13 -1.01 -20.27 -0.75 7.14e-60 Height; CRC trans rs1941687 0.800 rs1845387 chr18:31358940 T/G cg27147174 chr7:100797783 AP1S1 -0.36 -6.06 -0.32 3.67e-9 Subjective well-being (multi-trait analysis);Subjective well-being; CRC cis rs2762353 0.779 rs1408273 chr6:25840946 C/T cg03517284 chr6:25882590 NA 0.43 6.46 0.34 3.69e-10 Blood metabolite levels; CRC cis rs6502050 0.805 rs7406682 chr17:80084368 C/T cg09264619 chr17:80180166 NA 0.36 6.08 0.32 3.4e-9 Life satisfaction; CRC cis rs5753618 0.539 rs737888 chr22:31611549 A/G cg22777020 chr22:31556080 RNF185 -0.52 -6.0 -0.31 5.35e-9 Colorectal cancer; CRC cis rs798554 0.610 rs2644304 chr7:2878779 T/C cg13628971 chr7:2884303 GNA12 0.4 6.33 0.33 7.82e-10 Height; CRC cis rs1881797 1.000 rs1881796 chr1:247688931 G/A cg21399703 chr1:247681439 NA 0.47 7.69 0.39 1.68e-13 Acute lymphoblastic leukemia (childhood); CRC cis rs10193935 1.000 rs12622910 chr2:42398918 C/A cg27598129 chr2:42591480 NA -0.66 -7.46 -0.38 7.85e-13 Colonoscopy-negative controls vs population controls; CRC cis rs875971 0.862 rs6460290 chr7:65809106 G/A cg11764359 chr7:65958608 NA -0.6 -9.39 -0.46 1.03e-18 Aortic root size; CRC cis rs896854 0.548 rs574183 chr8:95973816 A/G cg13393036 chr8:95962371 TP53INP1 0.46 6.85 0.35 3.55e-11 Type 2 diabetes; CRC cis rs57994353 0.897 rs36101132 chr9:139367566 G/A cg14119001 chr9:139324193 INPP5E -0.44 -6.18 -0.32 1.9e-9 Eosinophil counts;Cutaneous squamous cell carcinoma; CRC trans rs10838798 0.504 rs7479393 chr11:48295303 G/C cg03929089 chr4:120376271 NA -0.46 -6.58 -0.34 1.83e-10 Height; CRC cis rs16867321 1.000 rs1358520 chr2:181440081 C/T cg23363182 chr2:181467187 NA -0.52 -6.54 -0.34 2.3e-10 Obesity; CRC cis rs28655083 0.913 rs7190129 chr16:77071456 G/A cg01753188 chr16:77233325 SYCE1L;MON1B -0.54 -7.75 -0.39 1.12e-13 Lobe attachment (rater-scored or self-reported); CRC cis rs12893668 0.703 rs4906336 chr14:104033265 C/G cg08213375 chr14:104286397 PPP1R13B 0.37 5.81 0.31 1.46e-8 Reticulocyte count; CRC cis rs870825 0.616 rs41278579 chr4:185622402 A/G cg04058563 chr4:185651563 MLF1IP 0.72 8.06 0.41 1.43e-14 Blood protein levels; CRC cis rs9400239 0.622 rs1268170 chr6:109007522 A/G cg11073813 chr6:109029018 NA -0.4 -6.33 -0.33 7.89e-10 Waist circumference;Body mass index;BMI (adjusted for smoking behaviour); CRC cis rs12824058 0.831 rs11609362 chr12:130810526 T/C cg26677194 chr12:130822605 PIWIL1 0.45 7.19 0.37 4.42e-12 Menopause (age at onset); CRC cis rs6964587 0.869 rs10250014 chr7:91490208 T/C cg17063962 chr7:91808500 NA -0.78 -13.29 -0.59 1.43e-32 Breast cancer; CRC cis rs7208859 0.623 rs56812022 chr17:29068733 A/G cg01831904 chr17:28903510 LRRC37B2 -0.62 -6.39 -0.33 5.8e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs17401966 0.540 rs4846216 chr1:10447792 A/T cg19773385 chr1:10388646 KIF1B 0.47 7.31 0.37 2.04e-12 Hepatocellular carcinoma; CRC cis rs2836974 0.897 rs34035316 chr21:40594023 T/C cg11644478 chr21:40555479 PSMG1 0.79 12.03 0.55 7.39e-28 Cognitive function; CRC cis rs35110281 0.805 rs2838330 chr21:45023876 T/A cg04455712 chr21:45112962 RRP1B 0.39 7.55 0.38 4.23e-13 Mean corpuscular volume; CRC cis rs11764590 0.715 rs56289396 chr7:2091415 G/A cg23378565 chr7:2036160 MAD1L1 -0.41 -5.68 -0.3 3.01e-8 Neuroticism; CRC trans rs9329221 0.736 rs2001337 chr8:10251154 G/A cg06636001 chr8:8085503 FLJ10661 0.52 7.65 0.39 2.18e-13 Neuroticism; CRC cis rs7615952 0.599 rs67575510 chr3:125742355 C/G cg04553112 chr3:125709451 NA -0.51 -5.71 -0.3 2.5e-8 Blood pressure (smoking interaction); CRC cis rs9486719 1.000 rs2273622 chr6:97058567 A/G cg18709589 chr6:96969512 KIAA0776 -0.5 -5.7 -0.3 2.73e-8 Migraine;Coronary artery disease; CRC cis rs1976403 0.659 rs10799699 chr1:21820961 C/T cg17800788 chr1:21766015 NBPF3 0.4 7.14 0.37 6.1e-12 Liver enzyme levels (alkaline phosphatase); CRC cis rs11030122 0.635 rs10835540 chr11:4071429 T/A cg18678763 chr11:4115507 RRM1 -0.48 -7.56 -0.38 4.05e-13 Mean platelet volume;Platelet distribution width; CRC cis rs2836974 0.568 rs2836969 chr21:40648265 G/A cg11890956 chr21:40555474 PSMG1 -0.91 -15.92 -0.66 1.01e-42 Cognitive function; CRC cis rs9910055 0.530 rs8072954 chr17:42294722 G/A cg19774624 chr17:42201019 HDAC5 -0.39 -5.85 -0.31 1.2e-8 Total body bone mineral density; CRC cis rs6840360 0.692 rs4479686 chr4:152399324 C/T cg09659197 chr4:152720779 NA 0.43 8.36 0.42 1.76e-15 Intelligence (multi-trait analysis); CRC cis rs1150668 0.699 rs2394049 chr6:28239681 A/G cg15845792 chr6:28175446 NA 0.48 7.17 0.37 5.1e-12 Pubertal anthropometrics; CRC cis rs1997103 1.000 rs4628219 chr7:55410449 A/G cg17469321 chr7:55412551 NA 0.72 11.28 0.53 3.48e-25 QRS interval (sulfonylurea treatment interaction); CRC cis rs35306767 0.951 rs11253530 chr10:993729 T/C cg20503657 chr10:835505 NA 1.01 12.33 0.56 5.53e-29 Eosinophil percentage of granulocytes; CRC trans rs1390943 1.000 rs13253777 chr8:20071770 C/G cg24796471 chr19:6737389 GPR108 -0.44 -6.15 -0.32 2.27e-9 Circulating myeloperoxidase levels (serum); CRC cis rs1559088 0.576 rs7251626 chr19:33578470 C/A cg17764715 chr19:33622953 WDR88 0.49 7.27 0.37 2.72e-12 Bone ultrasound measurement (broadband ultrasound attenuation); CRC cis rs11148252 0.740 rs9596648 chr13:52934569 A/T cg02158880 chr13:53174818 NA -0.45 -6.61 -0.34 1.52e-10 Lewy body disease; CRC cis rs9326248 0.813 rs474488 chr11:117068977 A/G cg26566898 chr11:117069891 TAGLN 0.39 6.99 0.36 1.54e-11 Blood protein levels; CRC cis rs9381040 0.655 rs9381031 chr6:41044957 A/T cg03644281 chr6:41068752 NFYA;LOC221442 -0.43 -6.02 -0.32 4.63e-9 Alzheimer's disease (late onset); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg23706161 chr2:109336669 RANBP2 0.43 6.71 0.35 8.51e-11 Liver disease severity in Alagille syndrome; CRC cis rs473651 0.935 rs558924 chr2:239339511 A/G cg18131467 chr2:239335373 ASB1 0.86 14.03 0.61 2.31e-35 Multiple system atrophy; CRC cis rs791888 0.965 rs791873 chr10:89405558 C/T cg13926569 chr10:89418898 PAPSS2 -0.44 -6.49 -0.34 3.15e-10 Magnesium levels; CRC cis rs6433857 0.505 rs7561255 chr2:181369216 A/G cg23363182 chr2:181467187 NA -0.53 -7.87 -0.4 5.01e-14 Body mass index; CRC cis rs35110281 0.720 rs162376 chr21:44926759 G/T cg01579765 chr21:45077557 HSF2BP 0.37 6.95 0.36 2e-11 Mean corpuscular volume; CRC cis rs10504229 0.639 rs17331850 chr8:58113538 G/T cg21724239 chr8:58056113 NA 0.49 6.77 0.35 5.94e-11 Developmental language disorder (linguistic errors); CRC cis rs9914988 0.945 rs9279 chr17:27187636 G/T cg12682573 chr17:27188876 MIR451;MIR144 -0.61 -9.06 -0.45 1.15e-17 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs4969178 0.965 rs2292643 chr17:76395421 G/A cg20026190 chr17:76395443 PGS1 0.4 6.22 0.32 1.47e-9 HDL cholesterol levels; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg06838869 chr7:140098259 SLC37A3 0.38 6.57 0.34 2.02e-10 Liver disease severity in Alagille syndrome; CRC cis rs9486719 0.948 rs2092095 chr6:96870864 T/G cg06623918 chr6:96969491 KIAA0776 0.81 9.48 0.46 5.18e-19 Migraine;Coronary artery disease; CRC cis rs4665809 0.590 rs7586047 chr2:26447335 A/G cg25036284 chr2:26402008 FAM59B -0.61 -7.76 -0.39 1.09e-13 Gut microbiome composition (summer); CRC cis rs2933343 1.000 rs789237 chr3:128636961 A/C cg11901034 chr3:128598214 ACAD9 -0.53 -6.53 -0.34 2.43e-10 IgG glycosylation; CRC cis rs1552244 0.810 rs4019706 chr3:10112862 G/A cg18598329 chr3:10140678 FANCD2;C3orf24 -0.88 -12.26 -0.56 1.03e-28 Alzheimer's disease; CRC cis rs7120118 0.517 rs10838694 chr11:47351760 G/A cg25783544 chr11:47291846 MADD 0.62 5.68 0.3 2.93e-8 HDL cholesterol; CRC cis rs172166 0.694 rs203877 chr6:28048624 T/C cg23161317 chr6:28129485 ZNF389 0.45 6.47 0.34 3.55e-10 Cardiac Troponin-T levels; CRC cis rs4654899 1.000 rs6684976 chr1:21367501 G/A cg02927042 chr1:21476669 EIF4G3 -0.46 -7.36 -0.38 1.44e-12 Superior frontal gyrus grey matter volume; CRC trans rs4927850 0.709 rs6783079 chr3:195652708 T/C cg16724585 chr3:197361211 NA -0.5 -6.54 -0.34 2.3e-10 Pancreatic cancer; CRC cis rs28386778 0.863 rs2665834 chr17:61904724 T/C cg23090583 chr17:61904693 PSMC5;FTSJ3 1.05 20.72 0.75 1.28e-61 Prudent dietary pattern; CRC cis rs832540 0.564 rs33329 chr5:56145068 T/C cg03609598 chr5:56110824 MAP3K1 -0.43 -5.8 -0.3 1.54e-8 Coronary artery disease; CRC trans rs4650994 0.525 rs4457535 chr1:178497186 C/T cg05059571 chr16:84539110 KIAA1609 0.57 7.87 0.4 5.32e-14 HDL cholesterol levels;HDL cholesterol; CRC cis rs2019137 0.936 rs2305133 chr2:113956821 C/G cg07772999 chr2:113993052 PAX8;LOC440839;LOC654433 -0.45 -6.34 -0.33 7.78e-10 Lymphocyte counts; CRC cis rs9467773 0.534 rs34453863 chr6:26628005 T/C cg09904177 chr6:26538194 HMGN4 0.6 8.59 0.43 3.56e-16 Intelligence (multi-trait analysis); CRC cis rs10927875 0.793 rs1763619 chr1:16326935 A/G cg10494257 chr1:16342123 HSPB7 0.45 6.06 0.32 3.72e-9 Dilated cardiomyopathy; CRC cis rs9837602 0.688 rs793492 chr3:99499736 T/C cg07805332 chr3:99536008 MIR548G;C3orf26 0.47 5.88 0.31 9.99e-9 Breast cancer; CRC cis rs1707322 0.721 rs7519900 chr1:46234947 C/T cg03146154 chr1:46216737 IPP 0.66 9.45 0.46 6.37e-19 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs2153535 0.580 rs1414344 chr6:8471365 C/A cg21535247 chr6:8435926 SLC35B3 0.5 7.56 0.38 4.18e-13 Motion sickness; CRC trans rs208515 0.525 rs10944859 chr6:66665197 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.93 11.75 0.54 7.56e-27 Exhaled nitric oxide levels; CRC trans rs11654801 0.947 rs16962375 chr17:20910984 G/T cg23759823 chr7:139672531 TBXAS1 -0.46 -6.81 -0.35 4.78e-11 Mosquito bite size; CRC trans rs9929218 1.000 rs13334326 chr16:68809207 C/T cg04657470 chr2:198365150 HSPE1;HSPD1 -0.82 -11.54 -0.54 4.33e-26 Colorectal cancer; CRC cis rs9916302 0.904 rs8070695 chr17:37478062 C/T cg07936489 chr17:37558343 FBXL20 0.77 11.37 0.53 1.67e-25 Glomerular filtration rate (creatinine); CRC cis rs561341 1.000 rs483301 chr17:30293398 G/T cg19193384 chr17:30244184 NA -0.65 -7.5 -0.38 6.06e-13 Hip circumference adjusted for BMI; CRC cis rs6860806 0.631 rs4705931 chr5:131588345 T/C cg18758796 chr5:131593413 PDLIM4 0.45 8.28 0.42 3.11e-15 Breast cancer; CRC cis rs6547741 0.874 rs58737572 chr2:27852118 A/C cg27432699 chr2:27873401 GPN1 0.78 13.95 0.61 4.55e-35 Oral cavity cancer; CRC cis rs10760158 0.865 rs10760165 chr9:124021254 C/T cg14417974 chr9:124058376 GSN -0.33 -5.63 -0.3 3.9e-8 Pulse pressure; CRC cis rs55794721 0.509 rs6699113 chr1:25777743 C/T cg02931644 chr1:25747376 RHCE 0.32 5.68 0.3 2.94e-8 Plateletcrit;Mean corpuscular volume; CRC cis rs11122272 0.735 rs2486730 chr1:231534987 T/G cg06096015 chr1:231504339 EGLN1 0.41 6.15 0.32 2.29e-9 Hemoglobin concentration; CRC cis rs1865760 0.625 rs9393681 chr6:26008260 A/G cg17691542 chr6:26056736 HIST1H1C 0.57 8.94 0.44 2.94e-17 Height; CRC cis rs2153535 0.580 rs9379213 chr6:8474945 G/A cg21535247 chr6:8435926 SLC35B3 0.49 7.4 0.38 1.14e-12 Motion sickness; CRC cis rs3750082 0.574 rs9639668 chr7:32912635 G/A cg05721444 chr7:32995514 FKBP9 0.52 6.49 0.34 3.15e-10 Glomerular filtration rate (creatinine); CRC cis rs4969178 0.560 rs4969182 chr17:76393030 T/C cg05887092 chr17:76393375 PGS1 0.65 12.81 0.58 9.66e-31 HDL cholesterol levels; CRC cis rs11098499 0.865 rs10213221 chr4:120255926 G/A cg09307838 chr4:120376055 NA 0.62 9.58 0.47 2.46e-19 Corneal astigmatism; CRC cis rs208520 0.526 rs9363522 chr6:66816642 C/T cg07460842 chr6:66804631 NA -1.18 -24.86 -0.81 1.65e-77 Exhaled nitric oxide output; CRC cis rs2836974 0.965 rs8131126 chr21:40655754 A/G cg06238570 chr21:40685208 BRWD1 0.76 10.35 0.5 6.42e-22 Cognitive function; CRC cis rs9303542 0.694 rs8071207 chr17:46584016 T/C cg04904318 chr17:46607828 HOXB1 0.45 5.97 0.31 5.99e-9 Ovarian cancer;Epithelial ovarian cancer; CRC cis rs9463078 0.691 rs1041332 chr6:45012811 A/T cg25276700 chr6:44698697 NA 0.24 5.82 0.31 1.37e-8 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; CRC cis rs9322193 0.923 rs3798761 chr6:150004779 A/G cg00933542 chr6:150070202 PCMT1 0.31 6.38 0.33 6.16e-10 Lung cancer; CRC cis rs853679 0.527 rs9468333 chr6:28271198 C/T cg15845792 chr6:28175446 NA 0.47 6.46 0.34 3.69e-10 Depression; CRC cis rs873946 0.557 rs34854637 chr10:134582962 A/G cg18305652 chr10:134549665 INPP5A 0.52 6.86 0.35 3.52e-11 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CRC cis rs1448094 0.511 rs17279133 chr12:86162353 G/A cg18827107 chr12:86230957 RASSF9 -0.37 -5.73 -0.3 2.23e-8 Major depressive disorder; CRC cis rs8078723 1.000 rs56922390 chr17:38157021 C/G cg17467752 chr17:38218738 THRA 0.73 11.82 0.55 4.15e-27 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); CRC cis rs78707713 0.560 rs17569412 chr10:71237536 C/A cg12610070 chr10:71211762 TSPAN15 -0.43 -7.51 -0.38 5.75e-13 Venous thromboembolism; CRC cis rs6684514 0.778 rs11264477 chr1:156321154 C/T cg16558208 chr1:156270281 VHLL 0.5 7.63 0.39 2.62e-13 Mean corpuscular hemoglobin concentration;Glycated hemoglobin levels; CRC cis rs10504229 0.645 rs35142596 chr8:58128151 C/T cg21724239 chr8:58056113 NA 0.49 6.81 0.35 4.75e-11 Developmental language disorder (linguistic errors); CRC trans rs57221529 0.713 rs12522724 chr5:590742 T/C cg11887960 chr12:57824829 NA 0.63 6.95 0.36 1.94e-11 Lung disease severity in cystic fibrosis; CRC cis rs798554 0.679 rs1614791 chr7:2888057 G/T cg19717773 chr7:2847554 GNA12 -0.45 -6.27 -0.33 1.13e-9 Height; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg21636432 chr6:35887842 SRPK1 0.46 6.45 0.34 4.08e-10 Response to antipsychotic treatment; CRC cis rs9911578 0.935 rs7218105 chr17:57041119 A/G cg05425664 chr17:57184151 TRIM37 -0.5 -7.88 -0.4 4.85e-14 Intelligence (multi-trait analysis); CRC cis rs1552244 0.515 rs111560858 chr3:10166845 G/A cg08888203 chr3:10149979 C3orf24 0.7 8.54 0.43 5.12e-16 Alzheimer's disease; CRC cis rs7539624 0.588 rs1892076 chr1:223899417 T/A cg10100437 chr1:223903862 CAPN2 0.46 6.46 0.34 3.84e-10 Schizophrenia; CRC cis rs9325144 0.647 rs1875609 chr12:39018259 C/T cg26384229 chr12:38710491 ALG10B -0.52 -7.39 -0.38 1.25e-12 Morning vs. evening chronotype; CRC cis rs4843747 0.671 rs28679286 chr16:88106307 C/T cg07865391 chr16:88106882 BANP 0.46 6.05 0.32 3.86e-9 Menopause (age at onset); CRC cis rs1008375 1.000 rs11722037 chr4:17683811 G/A cg04450456 chr4:17643702 FAM184B 0.39 6.27 0.33 1.1e-9 Parasitemia in Tripanosoma cruzi seropositivity; CRC trans rs1005277 0.540 rs7903942 chr10:37929276 C/T cg17830980 chr10:43048298 ZNF37B 0.44 6.9 0.36 2.74e-11 Extrinsic epigenetic age acceleration; CRC cis rs7662987 0.517 rs1133485 chr4:100023811 T/A cg13256891 chr4:100009986 ADH5 0.63 8.56 0.43 4.54e-16 Smoking initiation; CRC trans rs800082 1.000 rs4681378 chr3:144308005 C/T cg24215973 chr2:240111563 HDAC4 -0.52 -6.95 -0.36 1.95e-11 Smoking behavior; CRC cis rs990171 0.913 rs2241117 chr2:103003043 T/C cg03938978 chr2:103052716 IL18RAP 0.46 5.82 0.31 1.37e-8 Lymphocyte counts; CRC cis rs4478858 0.735 rs11436 chr1:31837320 T/C cg00250761 chr1:31883323 NA -0.44 -8.45 -0.42 9.35e-16 Alcohol dependence; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg01566955 chr10:71211468 TSPAN15 0.43 6.08 0.32 3.31e-9 Response to antipsychotic treatment; CRC cis rs832540 0.519 rs1445998 chr5:56268205 A/G cg18230493 chr5:56204884 C5orf35 -0.39 -5.96 -0.31 6.51e-9 Coronary artery disease; CRC cis rs12413816 0.963 rs10796116 chr10:13762786 C/T cg16485048 chr10:13749193 FRMD4A -0.48 -7.81 -0.4 7.98e-14 Red cell distribution width; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg26435092 chr3:133292540 CDV3 0.38 6.1 0.32 2.91e-9 Liver disease severity in Alagille syndrome; CRC trans rs629535 0.814 rs654452 chr8:70074344 C/G cg21567404 chr3:27674614 NA 0.92 15.32 0.65 2.38e-40 Dupuytren's disease; CRC cis rs6840360 0.608 rs6831644 chr4:152283746 A/G cg09659197 chr4:152720779 NA 0.37 7.31 0.37 2.06e-12 Intelligence (multi-trait analysis); CRC cis rs4665809 0.627 rs13014338 chr2:26463024 C/T cg22920501 chr2:26401640 FAM59B 0.83 11.96 0.55 1.28e-27 Gut microbiome composition (summer); CRC cis rs172166 0.611 rs203882 chr6:28078502 G/A cg06470822 chr6:28175283 NA 0.81 11.77 0.54 6.35e-27 Cardiac Troponin-T levels; CRC cis rs9625935 0.518 rs713718 chr22:30314092 A/C cg01021169 chr22:30184971 ASCC2 0.37 5.73 0.3 2.25e-8 Tonsillectomy; CRC cis rs704795 0.836 rs1647281 chr2:27612938 G/C cg12648201 chr2:27665141 KRTCAP3 -0.29 -5.76 -0.3 1.94e-8 Menopause (age at onset); CRC cis rs9372498 0.536 rs72954806 chr6:118899965 C/G cg24463073 chr6:118973353 C6orf204 0.54 7.24 0.37 3.26e-12 Diastolic blood pressure; CRC cis rs1046896 1.000 rs1046875 chr17:80685426 A/G cg16060761 chr17:80687452 NA 0.53 8.09 0.41 1.18e-14 Glycated hemoglobin levels; CRC cis rs6502050 0.835 rs7501527 chr17:80099355 A/C cg13198984 chr17:80129470 CCDC57 0.43 7.4 0.38 1.18e-12 Life satisfaction; CRC cis rs4268898 0.662 rs74470633 chr2:24438712 A/G cg06627628 chr2:24431161 ITSN2 -0.85 -11.56 -0.54 3.46e-26 Asthma; CRC trans rs9329221 0.905 rs4841329 chr8:10253098 A/G cg08975724 chr8:8085496 FLJ10661 -0.42 -6.41 -0.33 5.18e-10 Neuroticism; CRC cis rs921968 0.565 rs4672897 chr2:219588134 A/G cg02176678 chr2:219576539 TTLL4 -0.4 -6.39 -0.33 5.73e-10 Mean corpuscular hemoglobin concentration; CRC cis rs7666738 0.830 rs6851253 chr4:99029980 A/G cg05340658 chr4:99064831 C4orf37 0.61 9.42 0.46 8.23e-19 Colonoscopy-negative controls vs population controls; CRC cis rs9527 0.614 rs4919691 chr10:104624475 A/C cg04362960 chr10:104952993 NT5C2 0.62 8.62 0.43 2.91e-16 Arsenic metabolism; CRC cis rs2982552 0.873 rs2152750 chr6:152070145 C/T cg22157087 chr6:152012887 ESR1 -0.37 -5.66 -0.3 3.35e-8 Bone properties (heel); CRC cis rs9911578 1.000 rs7207693 chr17:57016525 C/T cg12560992 chr17:57184187 TRIM37 0.92 17.22 0.69 8.3e-48 Intelligence (multi-trait analysis); CRC cis rs2011503 0.941 rs72999068 chr19:19380685 A/G cg11584989 chr19:19387371 SF4 0.57 6.65 0.34 1.23e-10 Bipolar disorder; CRC cis rs9522267 0.535 rs9515452 chr13:112234553 A/G cg10483660 chr13:112241077 NA -0.48 -8.99 -0.44 2.04e-17 Hepatitis; CRC cis rs1355223 0.934 rs11602669 chr11:34695114 G/A cg11058730 chr11:34937778 PDHX;APIP -0.42 -5.68 -0.3 2.99e-8 Systemic lupus erythematosus and Systemic sclerosis; CRC cis rs9372498 0.536 rs9320660 chr6:118956827 A/T cg15382696 chr6:118971807 C6orf204 0.6 7.53 0.38 5.03e-13 Diastolic blood pressure; CRC cis rs4481887 0.927 rs4390208 chr1:248472211 C/T cg13385794 chr1:248469461 NA 0.37 6.53 0.34 2.56e-10 Common traits (Other); CRC cis rs7726839 0.540 rs3762951 chr5:662613 C/G cg14541582 chr5:601475 NA -0.33 -6.54 -0.34 2.39e-10 Obesity-related traits; CRC cis rs1129187 0.935 rs4987173 chr6:42931224 G/A cg05552183 chr6:42928497 GNMT 0.62 9.81 0.48 4.29e-20 Alzheimer's disease in APOE e4+ carriers; CRC cis rs7493 0.950 rs12704794 chr7:95036133 A/T cg04155289 chr7:94953770 PON1 -0.59 -7.53 -0.38 5.06e-13 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs11190604 1.000 rs11190541 chr10:102203071 A/G cg16342193 chr10:102329863 NA -0.37 -6.17 -0.32 2.02e-9 Palmitoleic acid (16:1n-7) levels; CRC trans rs1376359 0.673 rs1868828 chr1:103152118 A/C cg16220183 chr17:56609687 SEPT4 0.45 6.26 0.33 1.23e-9 QRS duration in Tripanosoma cruzi seropositivity; CRC cis rs875971 0.545 rs3936065 chr7:65790564 C/T cg03233332 chr7:66118400 NA -0.42 -5.83 -0.31 1.34e-8 Aortic root size; CRC cis rs801193 0.967 rs2707841 chr7:66157020 A/G cg11764359 chr7:65958608 NA 0.55 8.58 0.43 3.76e-16 Aortic root size; CRC cis rs78456975 1.000 rs10192959 chr2:1553393 G/T cg01028140 chr2:1542097 TPO -0.56 -5.73 -0.3 2.25e-8 Placebo response in major depressive disorder (% change in symptom score); CRC cis rs1451375 0.698 rs1813214 chr7:50637525 A/G cg14593290 chr7:50529359 DDC 0.51 7.11 0.37 7.09e-12 Malaria; CRC trans rs12599106 0.624 rs2173885 chr16:34992749 G/A cg20062050 chr1:227730881 NA 0.36 6.08 0.32 3.31e-9 Menopause (age at onset); CRC cis rs2952156 0.920 rs2517957 chr17:37838716 G/A cg11212589 chr17:38028394 ZPBP2 0.34 6.02 0.32 4.65e-9 Asthma; CRC trans rs4785204 1.000 rs7186983 chr16:50098852 C/T cg07960154 chr17:37760198 NEUROD2 -0.65 -6.05 -0.32 3.98e-9 Esophageal cancer (squamous cell); CRC cis rs11148252 0.532 rs9536262 chr13:53303074 A/C cg00495681 chr13:53174319 NA -0.83 -15.79 -0.66 3.46e-42 Lewy body disease; CRC cis rs4665809 0.590 rs3806514 chr2:26466772 C/T cg27170947 chr2:26402098 FAM59B 0.63 8.51 0.42 6.43e-16 Gut microbiome composition (summer); CRC cis rs11212617 1.000 rs186595 chr11:108251211 C/A cg01991180 chr11:108092276 ATM;NPAT 0.44 6.62 0.34 1.45e-10 Response to metformin in type 2 diabetes (glycemic); CRC cis rs6479527 0.625 rs1933667 chr9:96744109 G/C cg07076509 chr9:96720819 NA 0.36 5.98 0.31 5.71e-9 Esophageal adenocarcinoma; CRC cis rs7586879 0.828 rs2384056 chr2:25092649 G/A cg22495460 chr2:25135724 ADCY3 -0.83 -13.9 -0.61 7.3e-35 Body mass index; CRC cis rs7927771 0.832 rs4752993 chr11:47410951 T/C cg20307385 chr11:47447363 PSMC3 0.66 9.53 0.47 3.5e-19 Subjective well-being; CRC cis rs9462846 0.959 rs6937172 chr6:42884375 A/T cg02353165 chr6:42928485 GNMT 0.56 7.15 0.37 5.78e-12 Blood protein levels; CRC cis rs6502050 0.740 rs4789748 chr17:80093061 A/C cg19223190 chr17:80058835 NA 0.39 6.22 0.32 1.53e-9 Life satisfaction; CRC cis rs1448094 0.845 rs10863123 chr12:86346254 G/A cg19622623 chr12:86230825 RASSF9 -0.37 -6.03 -0.32 4.3e-9 Major depressive disorder; CRC cis rs11971779 0.818 rs12056045 chr7:139025430 C/G cg07862535 chr7:139043722 LUC7L2 1.04 12.44 0.57 2.17e-29 Diisocyanate-induced asthma; CRC cis rs2404602 0.583 rs12907668 chr15:76589767 A/T cg22467129 chr15:76604101 ETFA -0.48 -8.32 -0.42 2.35e-15 Blood metabolite levels; CRC cis rs514406 0.505 rs146750 chr1:53183447 C/G cg27535305 chr1:53392650 SCP2 -0.32 -5.71 -0.3 2.49e-8 Monocyte count; CRC cis rs7584330 0.554 rs112402109 chr2:238429058 A/G cg14458575 chr2:238380390 NA 0.6 7.79 0.39 8.81e-14 Prostate cancer; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg17482927 chr17:63133259 RGS9 0.46 6.24 0.33 1.37e-9 Thyroid stimulating hormone; CRC cis rs9527 0.662 rs10883783 chr10:104591152 T/A cg04362960 chr10:104952993 NT5C2 0.64 8.2 0.41 5.39e-15 Arsenic metabolism; CRC cis rs7727544 1.000 rs7727544 chr5:131590534 C/T cg02033258 chr5:131593261 PDLIM4 0.36 7.0 0.36 1.4e-11 Blood metabolite levels; CRC cis rs9462027 0.651 rs13220394 chr6:34810172 T/C cg07306190 chr6:34760872 UHRF1BP1 -0.34 -6.02 -0.32 4.63e-9 Systemic lupus erythematosus; CRC cis rs11212617 0.967 rs227074 chr11:108215095 A/G cg14761454 chr11:108092087 ATM;NPAT 0.43 6.47 0.34 3.66e-10 Response to metformin in type 2 diabetes (glycemic); CRC cis rs6998277 1.000 rs35155104 chr8:103646559 G/T cg10187029 chr8:103597600 NA 0.93 11.91 0.55 2.03e-27 Migraine; CRC cis rs12681287 0.577 rs11992955 chr8:87530485 A/G cg27223183 chr8:87520930 FAM82B 0.51 6.77 0.35 5.79e-11 Caudate activity during reward; CRC cis rs8060686 0.641 rs55790290 chr16:68180242 A/G cg08314208 chr16:67682810 RLTPR -0.53 -5.81 -0.3 1.5e-8 HDL cholesterol;Metabolic syndrome; CRC trans rs7395662 0.929 rs7108559 chr11:48619151 G/T cg21153622 chr11:89784906 NA -0.48 -7.69 -0.39 1.69e-13 HDL cholesterol; CRC cis rs7618915 0.547 rs6762813 chr3:52726695 C/T cg10802521 chr3:52805072 NEK4 -0.58 -8.94 -0.44 2.77e-17 Bipolar disorder; CRC cis rs7917772 0.636 rs1475644 chr10:104491164 G/A cg04362960 chr10:104952993 NT5C2 -0.46 -6.15 -0.32 2.29e-9 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC trans rs10982213 0.830 rs2274163 chr9:117188714 C/T cg03523603 chr1:150241529 APH1A 0.4 6.04 0.32 4.07e-9 Interleukin-6 levels; CRC cis rs4332037 0.539 rs55773130 chr7:2070554 T/C cg23378565 chr7:2036160 MAD1L1 -0.43 -6.15 -0.32 2.26e-9 Bipolar disorder; CRC cis rs13064411 0.735 rs6438158 chr3:113217290 C/T cg18753928 chr3:113234510 CCDC52 -0.7 -10.83 -0.51 1.45e-23 Response to simvastatin treatment (PCSK9 protein level change); CRC cis rs861020 1.000 rs861020 chr1:209977111 A/G cg09163369 chr1:210001066 C1orf107 0.6 7.72 0.39 1.38e-13 Orofacial clefts; CRC cis rs4713118 0.587 rs61471148 chr6:28037032 T/A cg02683197 chr6:28174875 NA 0.71 8.72 0.43 1.39e-16 Parkinson's disease; CRC cis rs8072100 0.875 rs4794047 chr17:45763005 A/T cg25173405 chr17:45401733 C17orf57 0.44 6.92 0.36 2.4e-11 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs7089973 0.872 rs35010779 chr10:116631816 A/C cg23260525 chr10:116636907 FAM160B1 0.32 6.87 0.35 3.2e-11 Bipolar disorder or attention deficit hyperactivity disorder; CRC cis rs77956314 0.515 rs4767490 chr12:117435016 A/G cg02017074 chr12:117425053 FBXW8 0.63 7.89 0.4 4.66e-14 Subcortical brain region volumes;Hippocampal volume; CRC cis rs3858526 0.676 rs10838772 chr11:5895754 T/C cg05234568 chr11:5960015 NA -0.54 -6.96 -0.36 1.9e-11 DNA methylation (variation); CRC cis rs57221529 0.664 rs72704802 chr5:554211 C/T cg16035780 chr5:759353 NA 0.42 5.68 0.3 3e-8 Lung disease severity in cystic fibrosis; CRC cis rs9467711 0.606 rs9393705 chr6:26361011 G/A cg14345882 chr6:26364793 BTN3A2 0.64 5.63 0.3 3.85e-8 Autism spectrum disorder or schizophrenia; CRC cis rs4285028 0.948 rs6790281 chr3:121665543 C/A cg20356878 chr3:121714668 ILDR1 -0.45 -6.59 -0.34 1.71e-10 Multiple sclerosis; CRC cis rs62244186 0.748 rs13319803 chr3:44635461 G/A cg10263370 chr3:44754102 ZNF502 -0.37 -6.12 -0.32 2.66e-9 Depressive symptoms; CRC cis rs644799 0.544 rs555556 chr11:95618425 T/G cg25622487 chr11:95524042 FAM76B;CEP57 0.54 8.09 0.41 1.17e-14 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs1223397 0.589 rs364493 chr6:13297020 C/T cg07912922 chr6:13274314 PHACTR1 -0.46 -6.78 -0.35 5.54e-11 Blood pressure; CRC cis rs11958404 0.517 rs13154764 chr5:157305206 T/C cg05962755 chr5:157440814 NA 0.79 8.71 0.43 1.54e-16 IgG glycosylation; CRC cis rs6089584 0.528 rs4925334 chr20:60626769 C/T cg06108461 chr20:60628389 TAF4 -0.74 -11.99 -0.55 1.01e-27 Body mass index; CRC cis rs7811142 0.830 rs76798830 chr7:99952828 C/T cg00814883 chr7:100076585 TSC22D4 -0.72 -8.71 -0.43 1.48e-16 Platelet count; CRC cis rs10504229 0.593 rs12216730 chr8:58003894 C/T cg21724239 chr8:58056113 NA 0.57 7.58 0.39 3.59e-13 Developmental language disorder (linguistic errors); CRC cis rs561341 0.609 rs4795659 chr17:30187139 C/G cg00745463 chr17:30367425 LRRC37B 0.54 6.66 0.34 1.12e-10 Hip circumference adjusted for BMI; CRC cis rs4363385 0.626 rs1108410 chr1:153005662 T/C cg25856811 chr1:152973957 SPRR3 -0.23 -6.18 -0.32 1.87e-9 Inflammatory skin disease; CRC cis rs738322 0.646 rs132972 chr22:38562056 T/C cg25457927 chr22:38595422 NA -0.31 -6.23 -0.32 1.44e-9 Cutaneous nevi; CRC cis rs9894429 0.966 rs7405901 chr17:79587813 T/C cg21984481 chr17:79567631 NPLOC4 -0.53 -9.8 -0.48 4.52e-20 Eye color traits; CRC cis rs2404602 0.692 rs12911902 chr15:77053575 T/C cg03037974 chr15:76606532 NA 0.69 11.69 0.54 1.23e-26 Blood metabolite levels; CRC cis rs9733 0.596 rs11204704 chr1:150671630 T/C cg10589385 chr1:150898437 SETDB1 0.3 6.25 0.33 1.26e-9 Tonsillectomy; CRC cis rs11690462 0.926 rs12615704 chr2:26551903 G/C cg22920501 chr2:26401640 FAM59B 0.4 5.7 0.3 2.63e-8 Coronary artery disease; CRC cis rs1799949 0.965 rs11650913 chr17:41331597 T/C cg25072359 chr17:41440525 NA 0.43 6.44 0.33 4.32e-10 Menopause (age at onset); CRC cis rs3858145 0.588 rs55888445 chr10:70036456 C/T cg06988349 chr10:69991859 ATOH7 0.36 5.69 0.3 2.76e-8 Optic nerve measurement (disc area);Optic cup area;Optic nerve measurement (cup area); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg02884346 chr4:6271501 WFS1 0.39 6.34 0.33 7.55e-10 Liver disease severity in Alagille syndrome; CRC trans rs916888 0.773 rs199533 chr17:44828931 G/A cg01341218 chr17:43662625 NA 0.98 10.06 0.49 6.35e-21 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs7119 0.717 rs12898370 chr15:77808598 A/T cg10437265 chr15:77819839 NA 0.68 12.38 0.56 3.64e-29 Type 2 diabetes; CRC cis rs514406 0.644 rs6662414 chr1:53198893 A/G cg25767906 chr1:53392781 SCP2 0.36 5.7 0.3 2.62e-8 Monocyte count; CRC cis rs6762 0.748 rs7936838 chr11:839093 G/C cg03885332 chr11:832357 CD151 -0.42 -6.23 -0.32 1.46e-9 Mean platelet volume; CRC cis rs2842992 0.830 rs2842966 chr6:160141592 C/T cg19482086 chr6:160211437 TCP1;MRPL18 0.67 8.47 0.42 8.46e-16 Age-related macular degeneration (geographic atrophy); CRC cis rs4713118 0.614 rs9468209 chr6:27694421 C/T cg25164649 chr6:28176230 NA 0.49 7.14 0.37 6.11e-12 Parkinson's disease; CRC cis rs1044826 0.597 rs6803593 chr3:139193987 T/C cg15131784 chr3:139108705 COPB2 0.39 5.64 0.3 3.61e-8 Obesity-related traits; CRC cis rs1448094 0.874 rs10779219 chr12:86322643 T/G cg02569458 chr12:86230093 RASSF9 0.37 6.47 0.34 3.47e-10 Major depressive disorder; CRC cis rs12249377 0.519 rs66650915 chr10:92592468 T/C cg14313238 chr10:92632228 RPP30 0.47 6.51 0.34 2.88e-10 White matter microstructure (global fractional anisotropy); CRC cis rs3733585 0.673 rs4235348 chr4:9951968 T/C cg11266682 chr4:10021025 SLC2A9 -0.47 -9.62 -0.47 1.76e-19 Cleft plate (environmental tobacco smoke interaction); CRC cis rs9649213 0.593 rs6465682 chr7:98016417 C/A cg24562669 chr7:97807699 LMTK2 0.44 7.25 0.37 3.09e-12 Prostate cancer (SNP x SNP interaction); CRC cis rs798554 0.679 rs1636249 chr7:2884283 T/G cg19346786 chr7:2764209 NA -0.36 -6.4 -0.33 5.33e-10 Height; CRC cis rs35306767 0.903 rs11253460 chr10:887382 C/G cg20503657 chr10:835505 NA 0.91 11.11 0.52 1.41e-24 Eosinophil percentage of granulocytes; CRC cis rs12220238 1.000 rs11000897 chr10:75911276 C/A cg19889307 chr10:75911429 ADK;AP3M1 0.63 6.15 0.32 2.31e-9 Soluble interleukin-2 receptor subunit alpha; CRC cis rs4332037 0.762 rs11770612 chr7:1915493 A/C cg21155852 chr7:2048760 MAD1L1 -0.4 -5.62 -0.3 4.03e-8 Bipolar disorder; CRC cis rs6539267 0.741 rs35816179 chr12:106693710 T/C cg00173435 chr12:106696525 TCP11L2 0.54 7.2 0.37 4.14e-12 Tourette syndrome; CRC cis rs9303280 0.806 rs9303279 chr17:38073968 G/C cg00129232 chr17:37814104 STARD3 0.45 6.84 0.35 3.82e-11 Self-reported allergy; CRC cis rs8177253 1.000 rs8177272 chr3:133482870 C/T cg16262614 chr3:133464971 TF 0.35 6.31 0.33 8.85e-10 Iron status biomarkers; CRC cis rs1030877 0.557 rs2278501 chr2:105979506 C/T cg02079111 chr2:105885981 TGFBRAP1 -0.46 -7.25 -0.37 3.02e-12 Obesity-related traits; CRC cis rs6815814 0.950 rs73236617 chr4:38793860 C/G cg06935464 chr4:38784597 TLR10 0.6 6.07 0.32 3.5e-9 Breast cancer; CRC cis rs2836974 0.899 rs2836938 chr21:40574191 C/T cg11890956 chr21:40555474 PSMG1 1.09 18.67 0.72 1.44e-53 Cognitive function; CRC cis rs561341 1.000 rs527256 chr17:30321293 C/G cg23018236 chr17:30244563 NA -0.67 -8.03 -0.4 1.78e-14 Hip circumference adjusted for BMI; CRC cis rs10256972 0.684 rs2363279 chr7:1096143 A/G cg22907277 chr7:1156413 C7orf50 0.5 7.36 0.38 1.48e-12 Longevity;Endometriosis; CRC cis rs7809950 0.817 rs62483725 chr7:107201575 G/A cg23024343 chr7:107201750 COG5 -0.76 -10.27 -0.49 1.23e-21 Coronary artery disease; CRC cis rs7584330 0.554 rs13390883 chr2:238432619 A/T cg14458575 chr2:238380390 NA 0.53 6.92 0.36 2.44e-11 Prostate cancer; CRC cis rs7221595 0.825 rs10521127 chr17:3978268 A/G cg05562828 chr17:3906858 NA 0.46 6.07 0.32 3.47e-9 Functional impairment in major depressive disorder, bipolar disorder and schizophrenia; CRC cis rs2228479 0.850 rs17233664 chr16:89810628 C/T cg06558623 chr16:89946397 TCF25 1.14 10.79 0.51 1.99e-23 Skin colour saturation; CRC cis rs40363 0.645 rs250629 chr16:3525431 C/A cg22508957 chr16:3507546 NAT15 0.6 9.31 0.46 1.81e-18 Tuberculosis; CRC cis rs728616 0.867 rs78131725 chr10:81820919 C/G cg05935833 chr10:81318306 SFTPA2 -0.56 -6.36 -0.33 6.81e-10 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs3091242 0.933 rs35530120 chr1:25785451 A/G cg20684491 chr1:25596433 NA -0.43 -7.44 -0.38 9.12e-13 Erythrocyte sedimentation rate; CRC cis rs7772486 0.875 rs9390372 chr6:146363638 G/C cg23711669 chr6:146136114 FBXO30 0.68 11.85 0.55 3.22e-27 Lobe attachment (rater-scored or self-reported); CRC cis rs10504229 0.683 rs11774697 chr8:58133119 G/A cg08219700 chr8:58056026 NA 0.56 6.74 0.35 7.02e-11 Developmental language disorder (linguistic errors); CRC cis rs875971 0.862 rs801209 chr7:66019390 G/T cg12463550 chr7:65579703 CRCP -0.47 -6.45 -0.33 4.03e-10 Aortic root size; CRC cis rs10979 1.000 rs9496681 chr6:143896964 G/A cg25407410 chr6:143891975 LOC285740 -0.84 -13.84 -0.61 1.22e-34 Hypospadias; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg25008156 chr6:170893875 PDCD2 0.45 6.86 0.35 3.36e-11 Liver disease severity in Alagille syndrome; CRC cis rs9640161 0.702 rs1962004 chr7:150020381 G/A cg12556325 chr7:150026731 C7orf29;LRRC61 -0.48 -6.78 -0.35 5.43e-11 Blood protein levels;Circulating chemerin levels; CRC cis rs7781557 0.640 rs55681588 chr7:102577338 C/G cg18108683 chr7:102477205 FBXL13 -0.49 -5.74 -0.3 2.14e-8 Colorectal adenoma (advanced); CRC cis rs6066835 0.764 rs2426103 chr20:47394490 A/C cg18078177 chr20:47281410 PREX1 -0.59 -5.99 -0.31 5.58e-9 Multiple myeloma; CRC cis rs514406 0.698 rs567880 chr1:53348564 T/G cg27535305 chr1:53392650 SCP2 -0.44 -7.88 -0.4 4.9e-14 Monocyte count; CRC cis rs1448094 0.817 rs10863112 chr12:86330844 C/T cg25456477 chr12:86230367 RASSF9 0.34 5.74 0.3 2.14e-8 Major depressive disorder; CRC trans rs2727020 0.514 rs4980444 chr11:49550764 T/A cg03929089 chr4:120376271 NA -0.92 -16.74 -0.68 6.08e-46 Coronary artery disease; CRC cis rs6502050 0.835 rs7212441 chr17:80080047 T/G cg02741985 chr17:80059408 CCDC57 -0.44 -7.17 -0.37 4.96e-12 Life satisfaction; CRC cis rs8060686 0.641 rs2418737 chr16:68122726 T/C cg08314208 chr16:67682810 RLTPR -0.5 -5.82 -0.31 1.37e-8 HDL cholesterol;Metabolic syndrome; CRC cis rs7605827 0.930 rs7596969 chr2:15513615 C/G cg19274914 chr2:15703543 NA -0.4 -6.16 -0.32 2.14e-9 Educational attainment (years of education); CRC cis rs921968 0.541 rs3821031 chr2:219295249 C/T cg02176678 chr2:219576539 TTLL4 -0.54 -8.63 -0.43 2.6e-16 Mean corpuscular hemoglobin concentration; CRC cis rs9322193 0.962 rs9322223 chr6:150122645 G/A cg05861140 chr6:150128134 PCMT1 -0.4 -6.63 -0.34 1.4e-10 Lung cancer; CRC cis rs7618501 0.603 rs72942333 chr3:49986118 T/C cg24110177 chr3:50126178 RBM5 -0.45 -6.71 -0.35 8.44e-11 Intelligence (multi-trait analysis); CRC cis rs11785693 0.866 rs11782170 chr8:4976942 A/G cg26367366 chr8:4980734 NA -0.64 -8.02 -0.4 1.93e-14 Neuroticism (multi-trait analysis);Neuroticism; CRC cis rs9914988 0.887 rs34644886 chr17:27168327 T/C cg12682573 chr17:27188876 MIR451;MIR144 0.56 7.55 0.38 4.38e-13 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg24786176 chr4:113153431 AP1AR 0.49 6.84 0.35 3.84e-11 Response to antipsychotic treatment; CRC cis rs10870270 0.956 rs6557 chr10:133781449 C/T cg08754478 chr10:133766260 PPP2R2D -0.66 -8.99 -0.44 2.04e-17 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; CRC cis rs769267 0.930 rs1047361 chr19:19606634 G/A cg03709012 chr19:19516395 GATAD2A 0.73 11.32 0.53 2.66e-25 Tonsillectomy; CRC cis rs68170813 0.559 rs77013162 chr7:107071674 A/C cg02696742 chr7:106810147 HBP1 -0.56 -5.79 -0.3 1.63e-8 Coronary artery disease; CRC cis rs4076764 0.522 rs10799914 chr1:163353205 A/G cg24596788 chr1:163392923 NA -0.5 -7.84 -0.4 6.28e-14 Motion sickness; CRC cis rs7666738 0.830 rs3846445 chr4:99032939 T/A cg05340658 chr4:99064831 C4orf37 0.61 9.42 0.46 8.23e-19 Colonoscopy-negative controls vs population controls; CRC cis rs1348850 0.958 rs1405713 chr2:178461560 G/C cg22681709 chr2:178499509 PDE11A -0.33 -6.08 -0.32 3.37e-9 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs6460942 0.591 rs62451464 chr7:12363059 C/A cg20607287 chr7:12443886 VWDE -0.55 -6.26 -0.33 1.2e-9 Coronary artery disease; CRC cis rs7385804 0.761 rs1734908 chr7:100313768 G/T cg16850897 chr7:100343110 ZAN 0.44 6.65 0.34 1.26e-10 Iron status biomarkers;Mean corpuscular hemoglobin;Hematocrit;Iron status biomarkers (transferrin saturation);Red blood cell count;Iron status biomarkers (iron levels);Mean corpuscular volume;Hematological parameters; CRC cis rs13191362 1.000 rs13201023 chr6:162981381 C/G cg23758597 chr6:163146217 PARK2 -0.56 -6.21 -0.32 1.59e-9 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs763014 0.966 rs4984903 chr16:680695 A/G cg03804128 chr16:635623 NA 0.29 6.78 0.35 5.49e-11 Height; CRC cis rs6460942 0.915 rs62448600 chr7:12454944 T/G cg20607287 chr7:12443886 VWDE -0.66 -6.93 -0.36 2.17e-11 Coronary artery disease; CRC cis rs7552404 1.000 rs441109 chr1:76120430 T/G cg03433033 chr1:76189801 ACADM -0.81 -11.2 -0.53 6.69e-25 Blood metabolite levels;Acylcarnitine levels; CRC cis rs10883723 0.773 rs1326193 chr10:104271674 G/T cg22532475 chr10:104410764 TRIM8 -0.36 -6.49 -0.34 3.13e-10 Allergic disease (asthma, hay fever or eczema); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg16203911 chr17:7590731 WRAP53;TP53 0.41 6.25 0.33 1.26e-9 Liver disease severity in Alagille syndrome; CRC cis rs7493 1.000 rs2286232 chr7:95039445 C/T cg20119798 chr7:94954144 PON1 -0.48 -6.19 -0.32 1.83e-9 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs7542091 0.704 rs7550330 chr1:210044587 G/A cg05527609 chr1:210001259 C1orf107 -0.44 -5.86 -0.31 1.15e-8 Monobrow; CRC cis rs1707322 1.000 rs10890359 chr1:46336635 A/G cg03146154 chr1:46216737 IPP 0.5 6.96 0.36 1.83e-11 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs1538970 0.962 rs3219489 chr1:45797505 C/G cg05343316 chr1:45956843 TESK2 0.67 8.89 0.44 4.04e-17 Platelet count; CRC cis rs8072100 0.817 rs9905581 chr17:45547185 C/T cg08085267 chr17:45401833 C17orf57 -0.62 -9.98 -0.48 1.12e-20 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs7618501 1.000 rs9872864 chr3:49792023 A/G cg24308560 chr3:49941425 MST1R 0.48 7.49 0.38 6.49e-13 Intelligence (multi-trait analysis); CRC cis rs9323205 0.871 rs8008599 chr14:51670057 A/G cg23942311 chr14:51606299 NA 0.57 7.82 0.4 7.23e-14 Cancer; CRC cis rs4665809 0.816 rs2384359 chr2:26371364 T/C cg26119090 chr2:26468346 HADHA;HADHB -0.76 -9.04 -0.45 1.38e-17 Gut microbiome composition (summer); CRC cis rs9905704 0.918 rs186221 chr17:56695967 C/T cg12560992 chr17:57184187 TRIM37 0.56 7.65 0.39 2.25e-13 Testicular germ cell tumor; CRC cis rs4665809 0.590 rs9309474 chr2:26448830 T/A cg27170947 chr2:26402098 FAM59B -0.59 -7.71 -0.39 1.53e-13 Gut microbiome composition (summer); CRC cis rs7772486 0.875 rs11155452 chr6:146424631 C/T cg13319975 chr6:146136371 FBXO30 -0.4 -6.11 -0.32 2.79e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs7503807 0.967 rs4889867 chr17:78593058 C/T cg09596252 chr17:78655493 RPTOR 0.4 6.3 0.33 9.55e-10 Obesity; CRC cis rs2692947 0.727 rs749459 chr2:96795714 G/A cg23100626 chr2:96804247 ASTL 0.29 7.97 0.4 2.58e-14 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; CRC cis rs9527 0.545 rs7095304 chr10:104954795 G/A cg15744005 chr10:104629667 AS3MT -0.29 -5.76 -0.3 1.92e-8 Arsenic metabolism; CRC cis rs9322193 0.923 rs10872650 chr6:150082095 A/G cg07701084 chr6:150067640 NUP43 0.59 8.65 0.43 2.31e-16 Lung cancer; CRC cis rs2227564 0.649 rs2948689 chr10:75657860 A/G cg16540259 chr10:75572220 NDST2 0.41 5.71 0.3 2.51e-8 Crohn's disease;Inflammatory bowel disease; CRC cis rs875971 0.545 rs73152714 chr7:65999628 G/A cg11764359 chr7:65958608 NA 0.45 5.78 0.3 1.77e-8 Aortic root size; CRC cis rs4689592 0.523 rs6446565 chr4:7074027 A/G cg19539972 chr4:7069911 GRPEL1 0.77 10.14 0.49 3.29e-21 Monocyte percentage of white cells; CRC cis rs2630709 0.562 rs3097266 chr2:8463495 T/C cg12167548 chr2:8464763 NA 0.35 6.67 0.34 1.11e-10 Monocyte percentage of white cells; CRC cis rs875971 0.964 rs60193905 chr7:65971260 A/G cg00343986 chr7:65444356 GUSB 0.44 6.52 0.34 2.6e-10 Aortic root size; CRC cis rs7923609 0.934 rs7923544 chr10:65182256 T/G cg08743896 chr10:65200160 JMJD1C -0.43 -6.16 -0.32 2.18e-9 Educational attainment;Liver enzyme levels (alkaline phosphatase); CRC cis rs59104589 0.920 rs1476698 chr2:242296449 A/G cg10021735 chr2:242295487 FARP2 0.4 5.78 0.3 1.7e-8 Fibrinogen levels; CRC cis rs9303280 0.806 rs35736272 chr17:38032680 T/C cg20243544 chr17:37824526 PNMT 0.37 5.74 0.3 2.17e-8 Self-reported allergy; CRC cis rs11711311 0.712 rs11718013 chr3:113341661 A/G cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.53 -7.08 -0.36 8.64e-12 IgG glycosylation; CRC cis rs6460942 0.915 rs17444141 chr7:12460971 T/G cg06484146 chr7:12443880 VWDE -0.78 -8.1 -0.41 1.11e-14 Coronary artery disease; CRC cis rs11212617 1.000 rs11212579 chr11:108150664 A/T cg12106634 chr11:108092400 ATM;NPAT 0.42 6.12 0.32 2.71e-9 Response to metformin in type 2 diabetes (glycemic); CRC cis rs172166 0.694 rs203876 chr6:28046673 T/C cg12172441 chr6:28176163 NA 0.52 7.11 0.37 7.2e-12 Cardiac Troponin-T levels; CRC cis rs7666738 0.830 rs13106434 chr4:98991651 T/A cg05340658 chr4:99064831 C4orf37 0.61 9.54 0.47 3.26e-19 Colonoscopy-negative controls vs population controls; CRC cis rs9611565 0.659 rs9607813 chr22:41941479 G/A cg06481639 chr22:41940642 POLR3H -0.51 -5.87 -0.31 1.08e-8 Vitiligo; CRC cis rs10924970 0.967 rs2152955 chr1:235417773 G/A cg26050004 chr1:235667680 B3GALNT2 0.39 5.8 0.3 1.54e-8 Asthma; CRC trans rs561341 0.882 rs72825748 chr17:30367396 G/A cg20587970 chr11:113659929 NA -1.41 -19.91 -0.74 1.98e-58 Hip circumference adjusted for BMI; CRC trans rs2303319 0.504 rs56405014 chr2:162497603 C/T cg14875682 chr5:52083620 ITGA1;PELO -0.76 -6.16 -0.32 2.13e-9 Cognitive function; CRC cis rs35306767 0.903 rs12264711 chr10:929525 T/C cg20503657 chr10:835505 NA 0.97 12.28 0.56 8.55e-29 Eosinophil percentage of granulocytes; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg24179850 chr19:56154938 ZNF581 0.39 6.19 0.32 1.78e-9 Liver disease severity in Alagille syndrome; CRC cis rs72634258 0.945 rs7522911 chr1:8097145 C/T cg26816564 chr1:7831052 VAMP3 0.55 5.91 0.31 8.49e-9 Inflammatory bowel disease; CRC cis rs394563 0.967 rs444784 chr6:149798366 C/G cg07828024 chr6:149772892 ZC3H12D -0.47 -8.33 -0.42 2.19e-15 Dupuytren's disease; CRC cis rs7259376 0.905 rs1975172 chr19:22534603 A/G cg02657401 chr19:22469223 NA -0.32 -7.02 -0.36 1.27e-11 Menopause (age at onset); CRC cis rs3096299 0.563 rs4600467 chr16:89562516 C/T cg00750074 chr16:89608354 SPG7 -0.46 -6.95 -0.36 1.91e-11 Multiple myeloma (IgH translocation); CRC cis rs2991971 0.967 rs11211130 chr1:45986852 G/C cg03123370 chr1:45965343 CCDC163P;MMACHC -0.4 -6.08 -0.32 3.42e-9 High light scatter reticulocyte count; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg11011774 chr17:19266179 B9D1 0.49 6.81 0.35 4.65e-11 Anxiety disorder; CRC cis rs1577917 0.740 rs7771612 chr6:86264374 T/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A 0.57 7.9 0.4 4.16e-14 Response to antipsychotic treatment; CRC cis rs8060686 0.641 rs7204192 chr16:68039309 A/G cg09835421 chr16:68378352 PRMT7 -0.48 -5.66 -0.3 3.37e-8 HDL cholesterol;Metabolic syndrome; CRC cis rs10504229 1.000 rs114486414 chr8:58185103 G/A cg24829409 chr8:58192753 C8orf71 -0.68 -11.34 -0.53 2.27e-25 Developmental language disorder (linguistic errors); CRC cis rs875971 0.660 rs6460308 chr7:66084740 T/C cg18876405 chr7:65276391 NA -0.62 -11.19 -0.52 7.76e-25 Aortic root size; CRC cis rs12802200 0.561 rs746708 chr11:572129 C/T cg16486109 chr11:613632 IRF7 0.58 10.24 0.49 1.53e-21 Systemic lupus erythematosus; CRC cis rs11627756 0.958 rs2146431 chr14:103071861 A/G cg12046867 chr14:103022105 NA 0.41 5.74 0.3 2.16e-8 Mean platelet volume; CRC cis rs6764363 0.527 rs115329276 chr3:282338 T/A cg02057681 chr3:285234 CHL1 0.42 7.08 0.36 8.63e-12 Sudden cardiac arrest; CRC cis rs3785574 0.962 rs4968660 chr17:61792221 G/A cg22520471 chr17:61851767 DDX42;CCDC47 0.44 6.11 0.32 2.82e-9 Height; CRC cis rs3096299 0.685 rs4785568 chr16:89553707 A/G cg01788221 chr16:89496183 ANKRD11 -0.38 -5.62 -0.3 4.05e-8 Multiple myeloma (IgH translocation); CRC trans rs8123881 0.733 rs7268466 chr20:15810676 C/T cg07899956 chr17:74261249 FAM100B 0.59 6.48 0.34 3.39e-10 Body mass index; CRC cis rs4722166 0.597 rs2069845 chr7:22770149 G/A cg05472934 chr7:22766657 IL6 0.68 11.51 0.54 5.32e-26 Lung cancer; CRC cis rs10193935 0.901 rs1044562 chr2:42516884 C/G cg27598129 chr2:42591480 NA -0.65 -7.5 -0.38 5.89e-13 Colonoscopy-negative controls vs population controls; CRC trans rs2303319 0.504 rs62189048 chr2:162613494 G/C cg23919916 chr10:103825097 HPS6 -0.69 -6.01 -0.31 4.8e-9 Cognitive function; CRC cis rs728616 0.867 rs61860420 chr10:81739379 G/A cg05935833 chr10:81318306 SFTPA2 -0.76 -8.28 -0.42 3.12e-15 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs875971 1.000 rs4718357 chr7:65960878 A/G cg12463550 chr7:65579703 CRCP 0.47 6.79 0.35 5.17e-11 Aortic root size; CRC cis rs3617 0.625 rs2240917 chr3:52851137 T/C cg11645453 chr3:52864694 ITIH4 0.46 9.05 0.45 1.3e-17 Red blood cell count;Autism spectrum disorder or schizophrenia; CRC trans rs13070584 1.000 rs16841339 chr3:99263041 C/T cg16683008 chr14:23494327 NA -0.71 -6.04 -0.32 4.15e-9 Chronic kidney disease and serum creatinine levels; CRC cis rs7208859 0.623 rs11650982 chr17:29129955 A/G cg13385521 chr17:29058706 SUZ12P 0.73 8.38 0.42 1.53e-15 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs4076764 0.914 rs7536270 chr1:163377379 T/C cg24596788 chr1:163392923 NA -0.65 -10.57 -0.5 1.15e-22 Motion sickness; CRC cis rs34172651 0.917 rs6497756 chr16:24798291 G/T cg06505273 chr16:24850292 NA 0.37 5.68 0.3 3.02e-8 Intelligence (multi-trait analysis); CRC cis rs4728302 0.869 rs6963032 chr7:133599527 T/C cg03336402 chr7:133662267 EXOC4 -0.45 -6.57 -0.34 1.93e-10 Intelligence;Intelligence (multi-trait analysis); CRC cis rs7772486 0.754 rs9399567 chr6:146147295 C/T cg23711669 chr6:146136114 FBXO30 0.73 12.65 0.57 3.77e-30 Lobe attachment (rater-scored or self-reported); CRC cis rs1799949 1.000 rs8074136 chr17:41342313 A/C cg19454999 chr17:41278357 BRCA1;NBR2 0.55 8.75 0.43 1.14e-16 Menopause (age at onset); CRC cis rs651907 0.535 rs58658478 chr3:101511667 G/A cg12386194 chr3:101231763 SENP7 0.51 7.26 0.37 2.88e-12 Colorectal cancer; CRC cis rs7811142 0.830 rs6975660 chr7:99975266 A/G cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.88 11.8 0.55 5.03e-27 Platelet count; CRC cis rs155076 0.711 rs4769158 chr13:21881975 T/C cg06138931 chr13:21896616 NA 0.56 7.14 0.37 6.03e-12 White matter hyperintensity burden; CRC cis rs4713118 0.869 rs9295743 chr6:27715102 G/C cg06470822 chr6:28175283 NA 0.72 10.35 0.5 6.55e-22 Parkinson's disease; CRC cis rs10504229 0.683 rs113492050 chr8:58130046 A/G cg02290350 chr8:58132656 NA -0.58 -8.16 -0.41 7.29e-15 Developmental language disorder (linguistic errors); CRC cis rs853679 0.546 rs200490 chr6:27796935 G/T cg19041857 chr6:27730383 NA -0.74 -7.3 -0.37 2.23e-12 Depression; CRC cis rs7618501 0.602 rs9311446 chr3:50092226 G/A cg24308560 chr3:49941425 MST1R 0.51 8.25 0.41 3.73e-15 Intelligence (multi-trait analysis); CRC cis rs4713675 0.584 rs6917140 chr6:33678394 C/G cg14003231 chr6:33640908 ITPR3 0.49 7.85 0.4 5.97e-14 Plateletcrit; CRC cis rs10771431 0.597 rs10771412 chr12:9354353 A/C cg08997352 chr12:9597637 DDX12 -0.45 -6.69 -0.35 9.48e-11 Breast size; CRC trans rs916888 0.610 rs199442 chr17:44820122 G/A cg07870213 chr5:140052090 DND1 0.64 8.34 0.42 2.01e-15 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs4363385 0.747 rs1015996 chr1:152976108 C/T cg25856811 chr1:152973957 SPRR3 -0.25 -6.76 -0.35 6.27e-11 Inflammatory skin disease; CRC cis rs9648716 0.810 rs2706775 chr7:140518968 C/T cg10747023 chr7:140774559 NA 0.44 5.76 0.3 1.94e-8 Type 2 diabetes; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg15356780 chr14:90422831 TDP1 0.5 6.56 0.34 2.09e-10 Thyroid stimulating hormone; CRC cis rs1223397 0.651 rs2439545 chr6:13313844 C/T cg07912922 chr6:13274314 PHACTR1 -0.37 -5.67 -0.3 3.17e-8 Blood pressure; CRC cis rs6761276 0.899 rs12711750 chr2:113835380 C/A cg24553058 chr2:113831203 IL1F10 0.4 6.44 0.33 4.26e-10 Protein quantitative trait loci; CRC cis rs28386778 0.897 rs2665833 chr17:61906846 T/C cg25654072 chr17:61904446 PSMC5;FTSJ3 0.72 11.23 0.53 5.39e-25 Prudent dietary pattern; CRC cis rs76878669 0.561 rs7117630 chr11:66154777 C/T cg24851651 chr11:66362959 CCS 0.34 5.67 0.3 3.17e-8 Educational attainment (years of education); CRC cis rs10256972 0.641 rs12702017 chr7:1129413 C/T cg27094323 chr7:1216898 NA -0.38 -6.12 -0.32 2.65e-9 Longevity;Endometriosis; CRC cis rs2050392 0.544 rs598672 chr10:30742388 C/T cg25182066 chr10:30743637 MAP3K8 -0.6 -8.58 -0.43 3.86e-16 Inflammatory bowel disease; CRC trans rs6788895 0.661 rs16862837 chr3:150469858 A/C cg12790874 chr13:100310405 CLYBL 0.62 6.51 0.34 2.86e-10 Breast cancer; CRC cis rs4862750 0.914 rs1991256 chr4:187875330 A/G cg03452623 chr4:187889614 NA -0.9 -20.37 -0.75 2.89e-60 Lobe attachment (rater-scored or self-reported); CRC cis rs10504229 0.817 rs10504230 chr8:58197150 A/G cg21724239 chr8:58056113 NA -0.51 -6.7 -0.35 9.03e-11 Developmental language disorder (linguistic errors); CRC cis rs12928939 0.517 rs8050058 chr16:71981374 T/G cg03805757 chr16:71968109 PKD1L3 -0.54 -7.27 -0.37 2.63e-12 Post bronchodilator FEV1; CRC cis rs11105298 1.000 rs11105298 chr12:89876143 C/T cg00757033 chr12:89920650 WDR51B -0.34 -5.75 -0.3 2.08e-8 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; CRC cis rs6546550 0.901 rs4144081 chr2:70155482 G/A cg02498382 chr2:70120550 SNRNP27 -0.56 -9.5 -0.46 4.59e-19 Prevalent atrial fibrillation; CRC cis rs8072100 0.967 rs2317826 chr17:45730899 C/T cg25173405 chr17:45401733 C17orf57 -0.46 -7.21 -0.37 3.76e-12 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs8177253 1.000 rs8177248 chr3:133479626 C/T cg16262614 chr3:133464971 TF 0.35 6.03 0.32 4.47e-9 Iron status biomarkers; CRC cis rs2227564 0.700 rs2688612 chr10:75653205 G/T cg00564723 chr10:75632066 CAMK2G -0.3 -7.04 -0.36 1.15e-11 Crohn's disease;Inflammatory bowel disease; CRC cis rs4919694 1.000 rs80327774 chr10:104656671 T/C cg04362960 chr10:104952993 NT5C2 1.14 10.25 0.49 1.46e-21 Arsenic metabolism; CRC cis rs11212617 1.000 rs600329 chr11:108163733 A/G cg14761454 chr11:108092087 ATM;NPAT 0.42 6.13 0.32 2.48e-9 Response to metformin in type 2 diabetes (glycemic); CRC cis rs10512697 0.655 rs35249343 chr5:3463116 G/C cg19473799 chr5:3511975 NA -0.83 -6.34 -0.33 7.66e-10 Immune response to smallpox vaccine (IL-6); CRC cis rs1552244 0.554 rs6768339 chr3:10006079 G/T cg00166722 chr3:10149974 C3orf24 -0.44 -6.51 -0.34 2.8e-10 Alzheimer's disease; CRC cis rs58785573 0.504 rs9522 chr4:38666972 C/T cg18361445 chr4:38666374 KLF3;FLJ13197 0.41 5.96 0.31 6.66e-9 Lymphocyte percentage of white cells; CRC cis rs6952808 1.000 rs4721121 chr7:1892565 A/G cg00106254 chr7:1943704 MAD1L1 -0.42 -6.14 -0.32 2.38e-9 Bipolar disorder and schizophrenia; CRC cis rs847649 0.842 rs1608651 chr7:102624192 C/T cg18108683 chr7:102477205 FBXL13 0.54 8.57 0.43 4.09e-16 Morning vs. evening chronotype; CRC cis rs669446 0.533 rs2158956 chr1:44211697 T/C cg12908607 chr1:44402522 ARTN -0.35 -6.16 -0.32 2.12e-9 Amyotrophic lateral sclerosis (age of onset); CRC cis rs6500602 1.000 rs12447826 chr16:4464617 T/C cg14951292 chr16:4525986 HMOX2;NMRAL1 0.52 7.42 0.38 1.02e-12 Schizophrenia; CRC trans rs8108034 1.000 rs39587 chr19:39806997 C/T cg24596729 chr1:165345813 NA -0.54 -6.42 -0.33 4.78e-10 Lung adenocarcinoma; CRC trans rs9291683 0.546 rs6820188 chr4:10051655 C/T cg26043149 chr18:55253948 FECH 0.52 7.88 0.4 4.98e-14 Bone mineral density; CRC trans rs7618501 1.000 rs11130219 chr3:49752427 C/T cg21582582 chr3:182698605 DCUN1D1 -0.56 -8.26 -0.41 3.59e-15 Intelligence (multi-trait analysis); CRC cis rs1552244 0.882 rs61429272 chr3:10037320 G/C cg18598329 chr3:10140678 FANCD2;C3orf24 -0.81 -10.69 -0.51 4.35e-23 Alzheimer's disease; CRC cis rs6141769 0.542 rs6057627 chr20:31306728 C/G cg13636640 chr20:31349939 DNMT3B -0.39 -5.92 -0.31 8.02e-9 Subjective well-being; CRC cis rs728616 0.867 rs56000427 chr10:81986946 A/G cg11900509 chr10:81946545 ANXA11 -0.73 -6.9 -0.36 2.69e-11 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs7524258 0.868 rs2157499 chr1:7271472 C/T cg07173049 chr1:7289937 CAMTA1 0.52 8.49 0.42 7.41e-16 Tourette's syndrome or obsessive-compulsive disorder; CRC cis rs1044826 0.642 rs9826544 chr3:139162831 A/G cg15131784 chr3:139108705 COPB2 0.41 5.93 0.31 7.87e-9 Obesity-related traits; CRC cis rs9326248 0.539 rs7120565 chr11:117042949 T/C cg20608306 chr11:116969690 SIK3 0.31 6.27 0.33 1.12e-9 Blood protein levels; CRC cis rs1322512 1.000 rs2800631 chr6:153008631 T/C cg03415253 chr6:152958462 SYNE1 0.39 6.01 0.31 4.94e-9 Tonometry; CRC cis rs7737355 0.947 rs31585 chr5:130999082 A/G cg06307176 chr5:131281290 NA 0.41 5.89 0.31 9.38e-9 Life satisfaction; CRC cis rs9443645 0.527 rs10943608 chr6:79674929 T/C cg05283184 chr6:79620031 NA -0.44 -6.4 -0.33 5.21e-10 Intelligence (multi-trait analysis); CRC cis rs1545257 0.537 rs4581852 chr2:24638256 C/A cg06627628 chr2:24431161 ITSN2 -0.47 -7.02 -0.36 1.27e-11 Sjögren's syndrome; CRC cis rs11574514 1.000 rs8049622 chr16:67800927 G/C cg26727032 chr16:67993705 SLC12A4 -0.61 -5.88 -0.31 1e-8 Crohn's disease; CRC cis rs13191362 0.938 rs28360532 chr6:162997477 T/C cg21926612 chr6:163149169 PACRG;PARK2 0.8 11.25 0.53 4.59e-25 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs262150 1.000 rs262154 chr7:158773936 G/A cg12590608 chr7:158785262 NA 0.44 7.46 0.38 7.7e-13 Facial morphology (factor 20); CRC cis rs7762018 1.000 rs73242910 chr6:170114670 A/G cg17545662 chr6:170176663 C6orf70 0.53 5.91 0.31 8.6e-9 Thiazide-induced adverse metabolic effects in hypertensive patients; CRC cis rs2836974 0.568 rs428602 chr21:40547004 A/G cg22974920 chr21:40686053 BRWD1 0.43 5.96 0.31 6.52e-9 Cognitive function; CRC cis rs6502050 0.835 rs4789724 chr17:80150546 G/A cg13198984 chr17:80129470 CCDC57 0.46 8.15 0.41 7.94e-15 Life satisfaction; CRC cis rs6570726 0.791 rs379040 chr6:145889035 T/C cg23711669 chr6:146136114 FBXO30 0.66 10.96 0.52 4.98e-24 Lobe attachment (rater-scored or self-reported); CRC cis rs6062302 0.522 rs6089929 chr20:62219679 C/T cg06363034 chr20:62225388 GMEB2 -0.44 -6.76 -0.35 6.44e-11 Glioblastoma; CRC cis rs6951245 1.000 rs77305932 chr7:1100861 T/A cg21664854 chr7:1097933 C7orf50;GPR146 0.77 8.8 0.44 7.85e-17 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs600806 0.888 rs3853498 chr1:109860144 T/C cg23032129 chr1:109941072 SORT1 -0.28 -6.04 -0.32 4.16e-9 Intelligence (multi-trait analysis); CRC cis rs2303759 0.918 rs4802597 chr19:49872085 C/T cg22133161 chr19:49891603 CCDC155 0.46 6.43 0.33 4.58e-10 Multiple sclerosis; CRC cis rs6964587 1.000 rs1859114 chr7:91682848 T/C cg17063962 chr7:91808500 NA 0.78 13.66 0.6 6e-34 Breast cancer; CRC cis rs9811920 0.609 rs793447 chr3:99598278 A/G cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G 0.46 6.18 0.32 1.87e-9 Axial length; CRC cis rs4713118 0.662 rs149900 chr6:28014597 C/T cg15845792 chr6:28175446 NA 0.89 12.53 0.57 1.03e-29 Parkinson's disease; CRC cis rs6546324 0.625 rs2861695 chr2:67846727 A/G cg15745817 chr2:67799979 NA -0.57 -9.7 -0.47 1.01e-19 Endometriosis; CRC cis rs3749237 0.595 rs11720264 chr3:49580347 C/T cg02487422 chr3:49467188 NICN1 0.44 7.13 0.37 6.26e-12 Resting heart rate; CRC cis rs9487051 0.676 rs1521905 chr6:109594515 T/C cg12927641 chr6:109611667 NA -0.38 -6.74 -0.35 7.22e-11 Reticulocyte fraction of red cells; CRC cis rs10504229 0.645 rs35142596 chr8:58128151 C/T cg04204079 chr8:58130323 NA -0.45 -5.78 -0.3 1.71e-8 Developmental language disorder (linguistic errors); CRC cis rs9359856 1.000 rs9359856 chr6:90307985 A/G cg13799429 chr6:90582589 CASP8AP2 -0.44 -6.45 -0.34 3.95e-10 Bipolar disorder; CRC cis rs11212617 0.840 rs228599 chr11:108107660 G/A cg14761454 chr11:108092087 ATM;NPAT 0.39 5.65 0.3 3.46e-8 Response to metformin in type 2 diabetes (glycemic); CRC cis rs4975709 0.589 rs931508 chr5:1861224 C/G cg20790798 chr5:1857306 NA -0.45 -7.11 -0.36 7.26e-12 Cardiovascular disease risk factors; CRC cis rs28386778 0.863 rs3760256 chr17:61821161 A/G cg23090583 chr17:61904693 PSMC5;FTSJ3 1.04 20.57 0.75 5.01e-61 Prudent dietary pattern; CRC cis rs6061231 0.793 rs2427320 chr20:60976723 A/G cg22601191 chr20:60968625 CABLES2 0.54 8.83 0.44 6.51e-17 Colorectal cancer; CRC cis rs853679 0.666 rs200956 chr6:27839746 A/G cg20933634 chr6:27740509 NA 0.53 6.39 0.33 5.74e-10 Depression; CRC cis rs4713118 0.597 rs172166 chr6:28020820 C/G cg23161317 chr6:28129485 ZNF389 0.43 5.71 0.3 2.46e-8 Parkinson's disease; CRC cis rs262150 0.672 rs2730230 chr7:158788529 A/G cg19418458 chr7:158789849 NA -0.43 -7.49 -0.38 6.55e-13 Facial morphology (factor 20); CRC cis rs7224685 0.501 rs6502770 chr17:4007314 A/G cg09597638 chr17:3907349 NA 0.56 9.64 0.47 1.55e-19 Type 2 diabetes; CRC trans rs1814175 0.935 rs11040462 chr11:49683158 G/A cg11707556 chr5:10655725 ANKRD33B -0.43 -7.94 -0.4 3.24e-14 Height; CRC cis rs6793245 0.810 rs7429945 chr3:38591689 T/C cg01465620 chr3:38496096 LOC100128640;ACVR2B -0.55 -8.05 -0.41 1.57e-14 QT interval; CRC cis rs10751667 0.600 rs7950955 chr11:1011490 G/A ch.11.42038R chr11:967971 AP2A2 0.57 9.05 0.45 1.31e-17 Alzheimer's disease (late onset); CRC cis rs738322 0.533 rs2284064 chr22:38547395 A/C cg25457927 chr22:38595422 NA -0.34 -6.83 -0.35 4.15e-11 Cutaneous nevi; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg23784313 chr12:15942613 EPS8 0.44 6.44 0.33 4.28e-10 Response to antipsychotic treatment; CRC cis rs2228479 0.702 rs62053702 chr16:89860688 G/T cg06558623 chr16:89946397 TCF25 1.18 11.57 0.54 3.24e-26 Skin colour saturation; CRC cis rs2404602 0.662 rs908817 chr15:76639191 G/A cg03037974 chr15:76606532 NA -0.49 -7.2 -0.37 4.24e-12 Blood metabolite levels; CRC cis rs17270561 0.553 rs6456696 chr6:25741408 A/G cg16482183 chr6:26056742 HIST1H1C 0.83 10.69 0.51 4.46e-23 Iron status biomarkers; CRC cis rs11676348 0.904 rs10804264 chr2:218955809 T/C cg04731861 chr2:219085781 ARPC2 0.3 6.22 0.32 1.49e-9 Ulcerative colitis; CRC cis rs3008870 0.755 rs1121824 chr1:67475616 C/A cg08660285 chr1:67390436 MIER1;WDR78 0.54 7.7 0.39 1.62e-13 Lymphocyte percentage of white cells; CRC cis rs2976388 0.647 rs2585138 chr8:143808951 C/T cg04969067 chr8:143858791 LYNX1 0.46 7.76 0.39 1.05e-13 Urinary tract infection frequency; CRC cis rs10743315 0.643 rs16915128 chr12:19304286 G/T cg02471346 chr12:19282374 PLEKHA5 -0.7 -6.65 -0.34 1.2e-10 Gut microbiota (bacterial taxa); CRC cis rs4713118 0.513 rs149955 chr6:28036225 G/C cg06470822 chr6:28175283 NA 0.8 11.76 0.54 6.84e-27 Parkinson's disease; CRC cis rs9549260 0.755 rs7324319 chr13:41233505 G/C cg21288729 chr13:41239152 FOXO1 0.49 7.7 0.39 1.63e-13 Red blood cell count; CRC cis rs6681460 0.966 rs9659879 chr1:67121434 T/C cg02459107 chr1:67143332 SGIP1 0.48 8.38 0.42 1.54e-15 Presence of antiphospholipid antibodies; CRC cis rs1552244 1.000 rs3895942 chr3:10108745 G/C cg08888203 chr3:10149979 C3orf24 0.69 9.74 0.47 7.48e-20 Alzheimer's disease; CRC cis rs1030268 1.000 rs748754 chr7:133509069 G/A cg03336402 chr7:133662267 EXOC4 -0.55 -7.07 -0.36 9.2e-12 Intelligence (multi-trait analysis); CRC cis rs2288073 1.000 rs6708328 chr2:24412413 A/G cg06627628 chr2:24431161 ITSN2 -0.67 -9.51 -0.46 4.03e-19 Venous thromboembolism (SNP x SNP interaction); CRC cis rs5769765 0.955 rs9616367 chr22:50303515 A/C cg04121214 chr22:50244548 NA 0.39 5.78 0.3 1.75e-8 Schizophrenia; CRC trans rs4263408 0.934 rs9683743 chr4:39703194 A/C cg06701443 chr5:173043757 BOD1 -0.41 -6.01 -0.31 4.9e-9 Plasma amyloid beta peptide concentrations (ABx-40); CRC cis rs780096 0.506 rs8395 chr2:27715207 T/A cg21248554 chr2:27665150 KRTCAP3 -0.31 -7.15 -0.37 5.66e-12 Total body bone mineral density; CRC cis rs12477438 0.798 rs896886 chr2:99652713 C/T cg26064155 chr2:99771622 LIPT1;TSGA10 0.75 10.63 0.51 7.23e-23 Chronic sinus infection; CRC cis rs12913538 0.962 rs10851714 chr15:62897029 A/G cg09983546 chr15:62884068 NA -0.61 -9.87 -0.48 2.74e-20 Sleep depth; CRC cis rs13315871 1.000 rs4585221 chr3:58415567 C/T cg20936604 chr3:58311152 NA -0.76 -7.15 -0.37 5.74e-12 Cholesterol, total; CRC cis rs6951245 1.000 rs74652290 chr7:1090109 G/A cg21664854 chr7:1097933 C7orf50;GPR146 0.73 8.33 0.42 2.18e-15 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs10461617 0.592 rs6450403 chr5:56062737 A/C cg24531977 chr5:56204891 C5orf35 -0.47 -6.18 -0.32 1.93e-9 Type 2 diabetes; CRC cis rs4074493 1.000 rs4658875 chr1:231168994 C/T cg22172038 chr1:231176991 FAM89A -0.35 -6.15 -0.32 2.21e-9 Carotid plaque burden (smoking interaction); CRC cis rs17681684 0.541 rs12150176 chr17:9764547 C/T cg26853458 chr17:9805074 RCVRN 0.53 9.33 0.46 1.66e-18 GIP levels in response to oral glucose tolerance test (fasting); CRC cis rs9291683 0.632 rs12508991 chr4:10041104 C/T cg11266682 chr4:10021025 SLC2A9 0.53 11.08 0.52 1.85e-24 Bone mineral density; CRC cis rs6804368 0.649 rs1350784 chr3:30754016 C/T cg06106510 chr3:30762233 NA 0.42 7.59 0.39 3.41e-13 Blood metabolite levels; CRC cis rs4363385 0.818 rs678960 chr1:153011621 G/A cg25856811 chr1:152973957 SPRR3 -0.25 -6.99 -0.36 1.51e-11 Inflammatory skin disease; CRC trans rs2055729 0.645 rs12056944 chr8:9742525 C/G cg06636001 chr8:8085503 FLJ10661 0.55 7.02 0.36 1.24e-11 Multiple myeloma (hyperdiploidy); CRC cis rs1552244 1.000 rs6782602 chr3:10116541 G/T cg00166722 chr3:10149974 C3orf24 0.67 9.23 0.45 3.37e-18 Alzheimer's disease; CRC cis rs2836974 0.932 rs6517526 chr21:40581530 T/C cg06238570 chr21:40685208 BRWD1 0.78 10.71 0.51 3.64e-23 Cognitive function; CRC cis rs1865760 1.000 rs2071299 chr6:25914801 G/A cg17691542 chr6:26056736 HIST1H1C 0.56 8.47 0.42 8.18e-16 Height; CRC cis rs11212617 1.000 rs227077 chr11:108253252 C/T cg14761454 chr11:108092087 ATM;NPAT 0.42 6.42 0.33 4.67e-10 Response to metformin in type 2 diabetes (glycemic); CRC cis rs274567 0.550 rs272885 chr5:131667736 A/G cg09877947 chr5:131593287 PDLIM4 0.44 7.23 0.37 3.46e-12 Blood metabolite levels; CRC cis rs67311347 1.000 rs7648952 chr3:40457038 C/T cg09455208 chr3:40491958 NA -0.43 -8.67 -0.43 2.03e-16 Renal cell carcinoma; CRC cis rs10504229 0.775 rs72650869 chr8:58157923 T/A cg02725872 chr8:58115012 NA -0.59 -9.18 -0.45 4.97e-18 Developmental language disorder (linguistic errors); CRC cis rs921968 0.541 rs933995 chr2:219650718 G/A cg02176678 chr2:219576539 TTLL4 -0.46 -7.28 -0.37 2.41e-12 Mean corpuscular hemoglobin concentration; CRC cis rs12618769 0.597 rs2278208 chr2:99154229 C/T cg18455616 chr2:99124870 INPP4A 0.36 5.92 0.31 8.23e-9 Bipolar disorder; CRC cis rs897984 0.683 rs13337900 chr16:30822409 G/A cg02466173 chr16:30829666 NA -0.8 -14.02 -0.61 2.53e-35 Dementia with Lewy bodies; CRC cis rs9322193 0.651 rs9322188 chr6:149909491 A/G cg07701084 chr6:150067640 NUP43 -0.53 -7.72 -0.39 1.39e-13 Lung cancer; CRC cis rs9814567 0.929 rs1534027 chr3:134284662 T/A cg06541857 chr3:134203789 ANAPC13;CEP63 -0.4 -6.01 -0.31 4.91e-9 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs2832191 0.716 rs2692625 chr21:30446360 C/G cg24692254 chr21:30365293 RNF160 0.85 16.11 0.66 1.88e-43 Dental caries; CRC trans rs13046373 0.905 rs4816372 chr21:32077414 A/T cg00978845 chr7:104752077 MLL5 -0.39 -6.82 -0.35 4.45e-11 HDL cholesterol; CRC cis rs9309473 0.950 rs10198549 chr2:73794404 A/G cg20560298 chr2:73613845 ALMS1 -0.47 -5.81 -0.3 1.5e-8 Metabolite levels; CRC cis rs28386778 0.897 rs8073515 chr17:61795328 A/C cg06873352 chr17:61820015 STRADA 0.76 14.24 0.62 3.45e-36 Prudent dietary pattern; CRC cis rs1218582 0.772 rs4240875 chr1:154885782 G/A cg16680214 chr1:154839983 KCNN3 -0.45 -8.86 -0.44 5.1e-17 Prostate cancer; CRC cis rs2408955 0.522 rs3997 chr12:48481587 T/C cg21466736 chr12:48725269 NA 0.51 7.72 0.39 1.45e-13 Glycated hemoglobin levels; CRC cis rs738322 0.600 rs6001031 chr22:38556260 G/T cg03162506 chr22:38580953 NA -0.27 -5.79 -0.3 1.69e-8 Cutaneous nevi; CRC trans rs4843747 0.671 rs13334603 chr16:88116016 T/C cg26811252 chr16:29126840 RRN3P2 0.71 9.65 0.47 1.42e-19 Menopause (age at onset); CRC cis rs7584330 0.554 rs77648388 chr2:238431832 G/C cg08992911 chr2:238395768 MLPH 0.63 6.31 0.33 9.11e-10 Prostate cancer; CRC cis rs2179367 0.959 rs480034 chr6:149735430 C/T cg07828024 chr6:149772892 ZC3H12D 0.39 6.17 0.32 2.04e-9 Dupuytren's disease; CRC cis rs897984 0.683 rs729482 chr16:31016970 T/C cg02466173 chr16:30829666 NA -0.56 -7.96 -0.4 2.74e-14 Dementia with Lewy bodies; CRC trans rs6089829 1.000 rs62207535 chr20:61669187 A/G cg23505145 chr19:12996616 KLF1 0.51 7.92 0.4 3.69e-14 Prostate cancer (SNP x SNP interaction); CRC cis rs9916302 0.645 rs1053651 chr17:37822311 A/C cg20243544 chr17:37824526 PNMT 0.53 8.38 0.42 1.59e-15 Glomerular filtration rate (creatinine); CRC cis rs1044826 0.667 rs295471 chr3:139213922 G/C cg00490450 chr3:139108681 COPB2 0.43 6.43 0.33 4.53e-10 Obesity-related traits; CRC cis rs2243480 1.000 rs1715235 chr7:65488394 T/C cg25985355 chr7:65971099 NA -0.5 -5.73 -0.3 2.25e-8 Diabetic kidney disease; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg24730871 chr19:19516902 GATAD2A 0.37 6.19 0.32 1.81e-9 Liver disease severity in Alagille syndrome; CRC cis rs2153535 0.580 rs9406171 chr6:8515362 T/C cg21535247 chr6:8435926 SLC35B3 0.49 7.43 0.38 9.25e-13 Motion sickness; CRC cis rs1472147 1.000 rs4323418 chr7:128506970 C/T cg00260937 chr7:128520193 KCP -0.39 -6.09 -0.32 3.2e-9 Calcium levels; CRC trans rs1945213 0.694 rs7122627 chr11:55862565 A/G cg03929089 chr4:120376271 NA 0.59 6.66 0.34 1.17e-10 Acute lymphoblastic leukemia (childhood); CRC cis rs13191362 1.000 rs13207671 chr6:162979056 A/G cg06582575 chr6:163149167 PACRG;PARK2 0.8 10.98 0.52 4.33e-24 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs3790645 1.000 rs1064196 chr1:26887592 C/T cg23229016 chr1:26872525 RPS6KA1 -0.3 -7.21 -0.37 3.89e-12 Glucose homeostasis traits; CRC trans rs6601327 0.641 rs11778555 chr8:9587574 C/T cg06636001 chr8:8085503 FLJ10661 -0.49 -7.19 -0.37 4.5e-12 Multiple myeloma (hyperdiploidy); CRC trans rs9650657 0.645 rs4841408 chr8:10516336 A/G cg06636001 chr8:8085503 FLJ10661 -0.45 -6.58 -0.34 1.86e-10 Neuroticism; CRC trans rs1728785 0.688 rs698718 chr16:68560185 A/G cg04657470 chr2:198365150 HSPE1;HSPD1 0.57 6.78 0.35 5.72e-11 Ulcerative colitis; CRC cis rs7178572 0.524 rs2175941 chr15:77584498 T/C cg22256960 chr15:77711686 NA -0.65 -9.46 -0.46 6.05e-19 Type 2 diabetes; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg00563090 chr7:148680266 NA 0.37 5.99 0.31 5.42e-9 Liver disease severity in Alagille syndrome; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg25947998 chr8:42948467 SGK196 0.5 6.45 0.34 4.02e-10 Thyroid stimulating hormone; CRC cis rs3091242 0.900 rs1883427 chr1:25744468 C/T cg23205692 chr1:25664452 TMEM50A 0.43 6.17 0.32 1.98e-9 Erythrocyte sedimentation rate; CRC cis rs6968419 0.674 rs6466571 chr7:115910045 A/G cg02561103 chr7:115862891 TES 0.42 6.25 0.33 1.29e-9 Intraocular pressure; CRC cis rs1728785 1.000 rs12925177 chr16:68569645 A/G cg02972257 chr16:68554789 NA 0.57 7.07 0.36 9.46e-12 Ulcerative colitis; CRC cis rs9322193 0.884 rs11155675 chr6:150064019 T/C cg07701084 chr6:150067640 NUP43 0.56 7.83 0.4 6.61e-14 Lung cancer; CRC cis rs79349575 0.594 rs62078375 chr17:47034974 A/G cg22482690 chr17:47019901 SNF8 0.49 8.09 0.41 1.16e-14 Type 2 diabetes; CRC cis rs968567 0.638 rs7943728 chr11:61547068 G/A cg16576620 chr11:61596068 FADS2 -0.51 -6.68 -0.35 1.05e-10 Blood metabolite levels;Rheumatoid arthritis;Vitiligo;Glycerophospholipid levels; CRC cis rs7937682 0.921 rs4616071 chr11:111440865 C/G cg09085632 chr11:111637200 PPP2R1B 0.98 15.85 0.66 1.96e-42 Primary sclerosing cholangitis; CRC cis rs1448094 0.802 rs56391398 chr12:86424114 C/T cg00310523 chr12:86230176 RASSF9 0.41 6.85 0.35 3.56e-11 Major depressive disorder; CRC cis rs2985684 0.948 rs11623263 chr14:50083295 A/G cg23565292 chr14:50234668 KLHDC2 -0.42 -5.84 -0.31 1.26e-8 Carotid intima media thickness; CRC cis rs1799949 1.000 rs11653460 chr17:41331306 C/T cg19454999 chr17:41278357 BRCA1;NBR2 0.53 8.28 0.42 3.22e-15 Menopause (age at onset); CRC cis rs6121246 0.954 rs6060989 chr20:30429763 C/T cg18721089 chr20:30220636 NA -0.36 -5.82 -0.31 1.39e-8 Mean corpuscular hemoglobin; CRC cis rs12282928 1.000 rs10769338 chr11:48294256 A/G cg20307385 chr11:47447363 PSMC3 -0.47 -5.88 -0.31 9.84e-9 Migraine - clinic-based; CRC cis rs7131987 0.617 rs3764953 chr12:29502236 T/C cg09582351 chr12:29534625 ERGIC2 -0.35 -7.58 -0.39 3.62e-13 QT interval; CRC cis rs311392 0.867 rs434952 chr8:55091998 C/T cg06042504 chr8:55087323 NA -0.44 -6.82 -0.35 4.41e-11 Pelvic organ prolapse (moderate/severe); CRC cis rs3858526 0.523 rs10769290 chr11:5886947 T/A cg02574844 chr11:5959923 NA -0.51 -7.59 -0.39 3.4e-13 DNA methylation (variation); CRC cis rs7258465 1.000 rs4808134 chr19:18608579 G/A cg06953865 chr19:18549723 ISYNA1 -0.37 -5.65 -0.3 3.56e-8 Breast cancer; CRC trans rs10506458 0.688 rs60936040 chr12:63416461 G/A cg03429785 chr15:59498649 MYO1E;LDHAL6B -1.03 -14.17 -0.62 6.58e-36 Hemostatic factors and hematological phenotypes; CRC cis rs7772486 0.754 rs864148 chr6:145976675 T/C cg05347473 chr6:146136440 FBXO30 -0.39 -5.86 -0.31 1.11e-8 Lobe attachment (rater-scored or self-reported); CRC trans rs1945380 0.964 rs1970728 chr11:80394267 C/G cg07625156 chr15:43426262 TMEM62 0.47 6.01 0.31 5.01e-9 Diabetic kidney disease; CRC cis rs8180040 0.726 rs1463393 chr3:46994987 G/A cg10298567 chr3:47292165 KIF9 0.37 5.84 0.31 1.28e-8 Colorectal cancer; CRC cis rs13191362 0.938 rs35760705 chr6:163020637 G/A cg06582575 chr6:163149167 PACRG;PARK2 0.72 10.27 0.49 1.21e-21 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs7264396 0.635 rs6119672 chr20:34479767 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.59 -9.96 -0.48 1.31e-20 Total cholesterol levels; CRC cis rs1519814 0.956 rs11774123 chr8:121119274 C/T cg22335954 chr8:121166405 COL14A1 0.52 6.28 0.33 1.05e-9 Breast cancer; CRC cis rs9910055 0.529 rs228746 chr17:42173752 T/C cg09913183 chr17:42254507 C17orf65;ASB16 -0.49 -6.62 -0.34 1.45e-10 Total body bone mineral density; CRC cis rs2953145 0.568 rs1133354 chr2:241522450 A/G cg07929629 chr2:241523174 NA 0.64 9.86 0.48 2.92e-20 Bipolar disorder; CRC trans rs7615952 0.512 rs2979351 chr3:125363599 C/T cg16558177 chr4:4109446 NA -0.62 -8.71 -0.43 1.55e-16 Blood pressure (smoking interaction); CRC cis rs4319547 1.000 rs4319547 chr12:123079035 A/G cg05707623 chr12:122985044 ZCCHC8 -0.76 -9.38 -0.46 1.13e-18 Body mass index; CRC cis rs1941023 0.503 rs10792269 chr11:60117126 C/T cg08716584 chr11:60157161 MS4A7 -0.46 -7.82 -0.4 7.4e-14 Congenital heart disease (maternal effect); CRC cis rs6840360 0.571 rs28454076 chr4:152520083 G/T cg09659197 chr4:152720779 NA 0.3 5.62 0.3 4.07e-8 Intelligence (multi-trait analysis); CRC cis rs8044868 0.586 rs6499557 chr16:72082654 A/G cg23815491 chr16:72088622 HP 0.5 7.23 0.37 3.35e-12 Body mass index (change over time) in cancer or chronic obstructive pulmonary disease;Body mass index (change over time) in cancer; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg07796735 chr12:49932860 KCNH3 0.4 6.22 0.32 1.52e-9 Liver disease severity in Alagille syndrome; CRC cis rs9398803 0.865 rs9398809 chr6:126789144 C/T cg19875578 chr6:126661172 C6orf173 0.43 5.94 0.31 7.11e-9 Male-pattern baldness; CRC cis rs6951245 0.935 rs11766669 chr7:1063593 C/T cg22907277 chr7:1156413 C7orf50 0.69 7.25 0.37 2.91e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC trans rs11098499 0.644 rs17517414 chr4:120262101 G/C cg25214090 chr10:38739885 LOC399744 0.55 9.01 0.44 1.69e-17 Corneal astigmatism; CRC cis rs853679 1.000 rs853694 chr6:28279100 A/T cg15845792 chr6:28175446 NA 0.58 5.88 0.31 9.81e-9 Depression; CRC cis rs4713118 0.662 rs4713120 chr6:27721835 C/A cg12172441 chr6:28176163 NA 0.45 6.35 0.33 7.19e-10 Parkinson's disease; CRC cis rs6499255 1.000 rs55992518 chr16:69821407 C/T cg15192750 chr16:69999425 NA 0.55 7.1 0.36 7.79e-12 IgE levels; CRC cis rs2153535 0.563 rs4428546 chr6:8490376 A/G cg21535247 chr6:8435926 SLC35B3 0.49 7.38 0.38 1.3e-12 Motion sickness; CRC cis rs9584850 0.834 rs745639 chr13:99119279 C/T cg07423050 chr13:99094983 FARP1 0.46 6.58 0.34 1.84e-10 Neuroticism; CRC trans rs1728785 1.000 rs864741 chr16:68576577 C/T cg04657470 chr2:198365150 HSPE1;HSPD1 0.58 7.0 0.36 1.46e-11 Ulcerative colitis; CRC cis rs9322193 0.962 rs9688750 chr6:149978769 T/C cg05861140 chr6:150128134 PCMT1 -0.43 -7.05 -0.36 1.04e-11 Lung cancer; CRC cis rs10540 0.730 rs34690033 chr11:492677 G/C cg21784768 chr11:537496 LRRC56 -0.68 -6.43 -0.33 4.37e-10 Body mass index; CRC cis rs898097 0.812 rs55794221 chr17:80849003 G/A cg15664640 chr17:80829946 TBCD -0.71 -11.82 -0.55 4.26e-27 Breast cancer; CRC cis rs11748023 0.605 rs155948 chr5:139519181 A/G cg26211634 chr5:139558579 C5orf32 -0.36 -6.2 -0.32 1.7e-9 Intelligence (multi-trait analysis); CRC trans rs6686842 0.932 rs1008505 chr1:41560235 C/T cg19787969 chr8:9763211 NA 0.28 6.05 0.32 3.99e-9 Height; CRC cis rs7833986 0.501 rs2953909 chr8:56968200 T/C cg23139584 chr8:56987506 RPS20;SNORD54 0.89 12.19 0.56 1.87e-28 Height; CRC trans rs7227892 0.659 rs9959212 chr18:46342442 C/T cg16735821 chr18:13727230 C18orf19;RNMT 0.51 6.52 0.34 2.6200000000000003e-10 Migraine with aura; CRC cis rs282587 0.569 rs377748 chr13:113405482 C/T cg04656015 chr13:113407548 ATP11A 0.58 7.04 0.36 1.15e-11 Glycated hemoglobin levels; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg03744954 chr7:23637556 CCDC126 0.39 6.11 0.32 2.79e-9 Response to antipsychotic treatment; CRC cis rs3733585 0.699 rs13328050 chr4:9951120 G/T cg00071950 chr4:10020882 SLC2A9 -0.51 -8.98 -0.44 2.14e-17 Cleft plate (environmental tobacco smoke interaction); CRC cis rs5750830 0.621 rs5750810 chr22:39792943 A/G cg24399712 chr22:39784796 NA -0.49 -9.79 -0.48 4.94e-20 Intelligence (multi-trait analysis); CRC cis rs6912958 0.967 rs6905947 chr6:88161949 C/T cg04972856 chr6:88032051 C6orf162;GJB7 -0.33 -5.9 -0.31 8.83e-9 Monocyte percentage of white cells; CRC cis rs7945718 0.621 rs4606460 chr11:12687781 A/G cg25843174 chr11:12811716 TEAD1 0.39 7.17 0.37 5.06e-12 Educational attainment (years of education); CRC trans rs800082 1.000 rs9289678 chr3:144307096 C/T cg24215973 chr2:240111563 HDAC4 0.51 6.9 0.36 2.73e-11 Smoking behavior; CRC cis rs9457247 0.637 rs9459846 chr6:167441023 T/G cg07741184 chr6:167504864 NA 0.36 6.38 0.33 6.18e-10 Crohn's disease; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg08998414 chr7:129483134 UBE2H 0.42 6.28 0.33 1.07e-9 Liver disease severity in Alagille syndrome; CRC cis rs4889855 0.530 rs7209279 chr17:78598055 T/A cg16591659 chr17:78472290 NA -0.43 -6.23 -0.32 1.42e-9 Fractional excretion of uric acid; CRC cis rs7666738 0.791 rs10856933 chr4:98958542 C/A cg05340658 chr4:99064831 C4orf37 0.61 9.54 0.47 3.45e-19 Colonoscopy-negative controls vs population controls; CRC cis rs1178968 0.748 rs10248063 chr7:72776008 T/G cg25889504 chr7:72793014 NA 0.54 6.12 0.32 2.63e-9 Triglyceride levels; CRC cis rs7618915 0.547 rs11130317 chr3:52731483 C/T cg05573699 chr3:52720067 GNL3;PBRM1 -0.46 -6.59 -0.34 1.76e-10 Bipolar disorder; CRC cis rs6964587 1.000 rs12530646 chr7:91588036 A/G cg17063962 chr7:91808500 NA -0.81 -14.39 -0.62 9.31e-37 Breast cancer; CRC cis rs10493773 0.674 rs414618 chr1:86220418 G/A cg00734567 chr1:86172782 ZNHIT6 0.4 6.08 0.32 3.39e-9 Urate levels in overweight individuals; CRC cis rs6582630 0.555 rs10880520 chr12:38464111 C/T cg13010199 chr12:38710504 ALG10B 0.49 6.58 0.34 1.87e-10 Drug-induced liver injury (flucloxacillin); CRC cis rs2688608 0.839 rs2633310 chr10:75594050 G/T cg00564723 chr10:75632066 CAMK2G 0.24 5.95 0.31 7.02e-9 Inflammatory bowel disease; CRC cis rs10779751 1.000 rs11121702 chr1:11293147 C/T cg08854313 chr1:11322531 MTOR 0.68 9.73 0.47 7.94e-20 Body mass index; CRC cis rs747650 0.504 rs7112854 chr11:47116823 T/C cg19486271 chr11:47235900 DDB2 0.44 5.89 0.31 9.76e-9 Acne (severe); CRC cis rs4665809 0.838 rs2243834 chr2:26357748 A/C cg04944784 chr2:26401820 FAM59B 0.62 8.03 0.4 1.74e-14 Gut microbiome composition (summer); CRC cis rs2708977 0.730 rs596069 chr2:97076642 C/T cg23100626 chr2:96804247 ASTL -0.24 -6.37 -0.33 6.53e-10 Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes; CRC cis rs6732160 0.934 rs2421390 chr2:73379103 T/C cg01422370 chr2:73384389 NA 0.33 5.67 0.3 3.17e-8 Intelligence (multi-trait analysis); CRC trans rs1005277 0.579 rs2505257 chr10:38372664 A/G cg11292332 chr7:45801988 SEPT13 -0.35 -6.1 -0.32 2.98e-9 Extrinsic epigenetic age acceleration; CRC trans rs6598955 0.671 rs7544 chr1:26607726 T/G cg07461501 chr17:79650226 HGS;ARL16 -0.52 -6.19 -0.32 1.77e-9 Obesity-related traits; CRC cis rs7618915 0.547 rs34610878 chr3:52759169 G/C cg10802521 chr3:52805072 NEK4 -0.59 -8.98 -0.44 2.07e-17 Bipolar disorder; CRC cis rs853679 0.517 rs9393894 chr6:28112562 A/G cg12963246 chr6:28129442 ZNF389 0.49 5.7 0.3 2.71e-8 Depression; CRC cis rs9487051 0.676 rs6933326 chr6:109601333 C/T cg12927641 chr6:109611667 NA -0.35 -6.25 -0.33 1.25e-9 Reticulocyte fraction of red cells; CRC cis rs2179367 0.919 rs577001 chr6:149646308 C/T cg07828024 chr6:149772892 ZC3H12D -0.39 -6.14 -0.32 2.39e-9 Dupuytren's disease; CRC cis rs875971 0.825 rs801202 chr7:66023929 C/T cg18876405 chr7:65276391 NA -0.52 -8.35 -0.42 1.91e-15 Aortic root size; CRC cis rs4665809 0.590 rs2033317 chr2:26477650 G/A cg22920501 chr2:26401640 FAM59B 0.84 12.46 0.57 1.94e-29 Gut microbiome composition (summer); CRC cis rs7727544 0.661 rs273900 chr5:131694606 G/A cg04518342 chr5:131593106 PDLIM4 0.33 5.82 0.31 1.39e-8 Blood metabolite levels; CRC cis rs875971 0.545 rs73150604 chr7:65945532 T/A cg05627663 chr7:65219948 SNORA22;CCT6P1 0.59 7.5 0.38 5.94e-13 Aortic root size; CRC trans rs7618501 0.933 rs6809431 chr3:49804119 A/G cg21665057 chr3:196295764 WDR53;FBXO45 0.86 15.79 0.66 3.5e-42 Intelligence (multi-trait analysis); CRC trans rs7619427 0.544 rs9872382 chr3:44021964 C/A cg09408571 chr1:101003634 GPR88 0.44 6.05 0.32 3.96e-9 Schizophrenia; CRC cis rs4862750 0.872 rs11947595 chr4:187899827 C/T cg07414643 chr4:187882934 NA 0.39 6.95 0.36 1.94e-11 Lobe attachment (rater-scored or self-reported); CRC cis rs1799949 0.930 rs35292991 chr17:41334016 C/A cg19454999 chr17:41278357 BRCA1;NBR2 0.54 8.34 0.42 2.13e-15 Menopause (age at onset); CRC cis rs755249 0.567 rs4660208 chr1:39722214 A/G cg18385671 chr1:39797026 MACF1 -0.43 -6.01 -0.31 4.86e-9 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs798554 0.660 rs2527687 chr7:2838485 G/A cg17321639 chr7:2759063 NA -0.43 -6.34 -0.33 7.77e-10 Height; CRC cis rs2404602 0.669 rs12148877 chr15:76919959 T/G cg23625390 chr15:77176239 SCAPER 0.48 7.06 0.36 9.99e-12 Blood metabolite levels; CRC cis rs13256369 0.901 rs13251887 chr8:8568678 G/A cg18904891 chr8:8559673 CLDN23 0.53 7.08 0.36 8.88e-12 Obesity-related traits; CRC cis rs1008375 0.932 rs6814465 chr4:17659034 C/T cg16339924 chr4:17578868 LAP3 0.52 6.58 0.34 1.9e-10 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs1005224 0.889 rs2059382 chr14:76158916 T/C cg25116370 chr14:76127843 TTLL5;C14orf1 -0.46 -7.11 -0.36 7.29e-12 Large artery stroke; CRC cis rs11122272 0.735 rs2790892 chr1:231512771 G/A cg06096015 chr1:231504339 EGLN1 0.4 5.95 0.31 6.7e-9 Hemoglobin concentration; CRC cis rs501120 1.000 rs552794 chr10:44771666 G/A cg09554077 chr10:44749378 NA 0.78 11.91 0.55 1.96e-27 Coronary artery disease;Coronary heart disease; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg21646186 chr1:110052458 AMIGO1 0.43 6.23 0.32 1.46e-9 Anxiety disorder; CRC cis rs4332037 0.762 rs11770612 chr7:1915493 A/C cg24505167 chr7:1915268 MAD1L1 -0.49 -7.44 -0.38 8.84e-13 Bipolar disorder; CRC cis rs6835098 1.000 rs6814857 chr4:174082805 T/A cg08422745 chr4:174089978 GALNT7 -0.95 -15.03 -0.64 3.21e-39 Dementia and core Alzheimer's disease neuropathologic changes; CRC cis rs11628318 0.614 rs7143783 chr14:103128751 A/G cg23071808 chr14:103021642 NA 0.62 6.96 0.36 1.82e-11 Platelet count; CRC cis rs57994353 0.600 rs1130640 chr9:139317979 C/T cg14119001 chr9:139324193 INPP5E -0.44 -5.89 -0.31 9.75e-9 Eosinophil counts;Cutaneous squamous cell carcinoma; CRC cis rs66573146 0.808 rs56268690 chr4:6923887 C/T cg00086871 chr4:6988644 TBC1D14 1.06 7.57 0.39 3.68e-13 Granulocyte percentage of myeloid white cells; CRC cis rs2404602 0.716 rs1588961 chr15:76752698 A/G cg22467129 chr15:76604101 ETFA -0.45 -7.71 -0.39 1.46e-13 Blood metabolite levels; CRC cis rs1580019 0.587 rs7805311 chr7:32558302 A/G cg14728415 chr7:32535168 LSM5;AVL9 -0.45 -6.38 -0.33 5.99e-10 Cognitive ability; CRC cis rs1878931 0.580 rs4578649 chr16:3407258 C/T cg26668626 chr16:3451006 ZNF174;ZNF434 -0.83 -13.35 -0.59 8.98e-33 Body mass index (adult); CRC cis rs7927592 0.763 rs7119422 chr11:68331154 C/T cg01657329 chr11:68192670 LRP5 0.58 9.89 0.48 2.32e-20 Total body bone mineral density; CRC cis rs1451375 0.527 rs6950777 chr7:50597056 G/A cg14593290 chr7:50529359 DDC 0.55 7.57 0.38 3.88e-13 Malaria; CRC cis rs2019137 0.901 rs4849176 chr2:113977936 C/T cg21610815 chr2:113994035 PAX8;LOC654433;LOC440839 -0.43 -6.12 -0.32 2.63e-9 Lymphocyte counts; CRC cis rs2576037 0.583 rs644731 chr18:44426877 C/T cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.53 -8.31 -0.42 2.59e-15 Personality dimensions; CRC cis rs11170631 0.507 rs12307701 chr12:54090724 A/C cg06632207 chr12:54070931 ATP5G2 0.36 6.14 0.32 2.36e-9 Height; CRC cis rs7178572 0.568 rs8037561 chr15:77680462 A/G cg22256960 chr15:77711686 NA -0.66 -9.6 -0.47 2.13e-19 Type 2 diabetes; CRC cis rs9649213 0.537 rs35997266 chr7:97965566 T/C cg21770322 chr7:97807741 LMTK2 0.53 8.69 0.43 1.73e-16 Prostate cancer (SNP x SNP interaction); CRC cis rs11626933 1.000 rs2236402 chr14:90734378 C/G cg14092571 chr14:90743983 NA -0.92 -15.22 -0.64 5.67e-40 Gut microbiota (bacterial taxa); CRC cis rs1003719 0.688 rs2835662 chr21:38568967 T/A cg10648535 chr21:38446584 PIGP;TTC3 -0.45 -6.23 -0.32 1.41e-9 Eye color traits; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg22228296 chr3:141457315 RNF7 0.46 6.43 0.33 4.39e-10 Response to antipsychotic treatment; CRC trans rs11098499 0.865 rs28634456 chr4:120375778 A/G cg25214090 chr10:38739885 LOC399744 0.64 9.76 0.47 6.41e-20 Corneal astigmatism; CRC cis rs11155671 0.530 rs7758020 chr6:150208111 T/C cg07701084 chr6:150067640 NUP43 0.49 7.17 0.37 4.95e-12 Testicular germ cell tumor; CRC cis rs4642101 0.597 rs9839769 chr3:12821405 C/T cg24848339 chr3:12840334 CAND2 0.34 6.35 0.33 6.98e-10 QRS complex (12-leadsum); CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg17436946 chr4:39699568 UBE2K -0.4 -6.05 -0.32 3.85e-9 Myopia (pathological); CRC cis rs9311474 0.629 rs7639267 chr3:52568805 G/T cg11645453 chr3:52864694 ITIH4 0.34 6.32 0.33 8.61e-10 Electroencephalogram traits; CRC cis rs7385804 0.727 rs221790 chr7:100278282 G/C cg16850897 chr7:100343110 ZAN 0.46 7.01 0.36 1.37e-11 Iron status biomarkers;Mean corpuscular hemoglobin;Hematocrit;Iron status biomarkers (transferrin saturation);Red blood cell count;Iron status biomarkers (iron levels);Mean corpuscular volume;Hematological parameters; CRC cis rs7249142 0.549 rs539 chr19:19287802 A/G cg26504305 chr19:19281019 LOC729991-MEF2B;MEF2B -0.43 -8.61 -0.43 3.03e-16 IgG glycosylation; CRC cis rs992157 0.798 rs10206064 chr2:219157959 T/C cg04731861 chr2:219085781 ARPC2 -0.3 -6.22 -0.32 1.47e-9 Colorectal cancer; CRC cis rs1448094 0.511 rs17279240 chr12:86162550 A/T cg25456477 chr12:86230367 RASSF9 0.38 6.43 0.33 4.41e-10 Major depressive disorder; CRC trans rs1864729 1.000 rs2053481 chr8:98278923 C/T cg08679828 chr8:102218111 ZNF706 -0.6 -7.23 -0.37 3.37e-12 Estradiol plasma levels (breast cancer); CRC cis rs9303401 0.527 rs34835800 chr17:56764990 G/A cg10487724 chr17:56770010 TEX14;RAD51C 0.76 9.1 0.45 8.64e-18 Cognitive test performance; CRC cis rs2180341 0.782 rs6569490 chr6:127729615 C/T cg27446573 chr6:127587934 RNF146 0.69 9.42 0.46 8.11e-19 Breast cancer; CRC cis rs4665809 0.941 rs2289021 chr2:26362515 A/C cg26119090 chr2:26468346 HADHA;HADHB 0.65 8.12 0.41 9.7e-15 Gut microbiome composition (summer); CRC cis rs6088580 0.624 rs6120645 chr20:33025171 C/T cg08999081 chr20:33150536 PIGU 0.61 11.58 0.54 2.94e-26 Glomerular filtration rate (creatinine); CRC trans rs17126268 0.502 rs2185432 chr1:102878478 T/G cg18468354 chr14:36993517 NA 0.38 6.12 0.32 2.65e-9 Glomerular filtration rate; CRC cis rs4332037 0.539 rs55988458 chr7:2059761 G/A cg02825527 chr7:2087843 MAD1L1 -0.48 -5.78 -0.3 1.75e-8 Bipolar disorder; CRC cis rs4713118 0.868 rs760587 chr6:27740300 C/A cg20933634 chr6:27740509 NA 0.63 7.28 0.37 2.52e-12 Parkinson's disease; CRC cis rs17065868 0.764 rs61949769 chr13:45023064 C/G cg10246903 chr13:45222710 NA 0.57 6.28 0.33 1.06e-9 Antineutrophil cytoplasmic antibody-associated vasculitis; CRC cis rs769267 0.965 rs2315024 chr19:19423817 T/A cg02546618 chr19:19431379 KIAA0892;SF4 0.45 6.26 0.33 1.22e-9 Tonsillectomy; CRC cis rs7707921 0.767 rs862241 chr5:81588011 G/A cg07807695 chr5:81608485 ATP6AP1L -0.47 -7.38 -0.38 1.3e-12 Breast cancer; CRC cis rs6554196 0.932 rs6825657 chr4:55515359 A/G cg18836493 chr4:55524333 KIT -0.34 -5.73 -0.3 2.22e-8 Monocyte count; CRC cis rs12748961 0.557 rs823127 chr1:205713139 G/A cg23034840 chr1:205782522 SLC41A1 0.48 6.47 0.34 3.51e-10 White blood cell types; CRC cis rs17253792 0.822 rs112739186 chr14:56065167 A/T cg01858014 chr14:56050164 KTN1 -0.85 -6.69 -0.35 9.81e-11 Putamen volume; CRC cis rs12497850 0.931 rs7430501 chr3:48890119 C/T cg07636037 chr3:49044803 WDR6 1.04 18.72 0.72 9.87e-54 Parkinson's disease; CRC cis rs11608355 0.545 rs4766604 chr12:109892179 T/C cg05360138 chr12:110035743 NA 0.77 8.7 0.43 1.65e-16 Neuroticism; CRC cis rs6570726 0.689 rs411785 chr6:145888398 G/A cg05347473 chr6:146136440 FBXO30 0.4 6.08 0.32 3.28e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs2251381 0.750 rs2776250 chr21:30528094 T/G cg08807101 chr21:30365312 RNF160 0.66 9.92 0.48 1.79e-20 Selective IgA deficiency; CRC trans rs1814175 0.817 rs10769618 chr11:49822336 A/G cg15704280 chr7:45808275 SEPT13 -0.98 -18.93 -0.72 1.46e-54 Height; CRC trans rs2303319 0.582 rs12464282 chr2:162448855 C/T cg27113153 chr11:123612418 ZNF202 -0.7 -6.15 -0.32 2.28e-9 Cognitive function; CRC cis rs7680126 0.596 rs17418533 chr4:10316941 T/C cg00071950 chr4:10020882 SLC2A9 -0.47 -6.12 -0.32 2.69e-9 Urate levels in lean individuals;Urate levels in overweight individuals;Urate levels in obese individuals; CRC cis rs1865760 1.000 rs3799371 chr6:25912816 A/G cg17691542 chr6:26056736 HIST1H1C -0.56 -8.47 -0.42 8.21e-16 Height; CRC cis rs7917772 0.582 rs10883738 chr10:104321721 T/C cg11453585 chr10:104263688 ACTR1A;SUFU 0.82 15.27 0.64 3.5e-40 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC cis rs3617 0.625 rs6445541 chr3:52880128 G/T cg11645453 chr3:52864694 ITIH4 0.37 6.7 0.35 8.94e-11 Red blood cell count;Autism spectrum disorder or schizophrenia; CRC cis rs6558530 0.692 rs10105317 chr8:1701432 G/A cg19131313 chr8:1704013 NA -0.48 -5.74 -0.3 2.17e-8 Systolic blood pressure; CRC cis rs8077889 0.956 rs6503476 chr17:41850163 C/T cg16892393 chr17:41919603 NA 0.44 6.45 0.33 4.09e-10 Triglycerides; CRC cis rs11098499 0.697 rs11941899 chr4:120382758 C/A cg09307838 chr4:120376055 NA 0.71 10.92 0.52 6.75e-24 Corneal astigmatism; CRC cis rs79387448 0.745 rs1523196 chr2:103163700 T/G cg00507830 chr2:103233733 NA 0.51 5.61 0.3 4.25e-8 Gut microbiota (bacterial taxa); CRC cis rs1448094 0.621 rs10863091 chr12:86282240 T/C cg02569458 chr12:86230093 RASSF9 0.38 6.29 0.33 9.9e-10 Major depressive disorder; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg09888562 chr16:54318314 IRX3 0.29 6.02 0.31 4.73e-9 Liver disease severity in Alagille syndrome; CRC cis rs4819052 1.000 rs9306123 chr21:46709922 A/G cg19498844 chr21:46707878 POFUT2;LOC642852 0.84 10.98 0.52 4.18e-24 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs798554 0.660 rs2644275 chr7:2854010 G/A cg04166393 chr7:2884313 GNA12 0.38 5.79 0.3 1.67e-8 Height; CRC trans rs7267979 1.000 rs2027003 chr20:25350498 A/G cg17903999 chr18:56338584 MALT1 0.41 6.66 0.34 1.14e-10 Liver enzyme levels (alkaline phosphatase); CRC cis rs9381040 0.655 rs4140578 chr6:41041829 A/G cg09580153 chr6:41068724 NFYA;LOC221442 -0.44 -6.41 -0.33 4.97e-10 Alzheimer's disease (late onset); CRC cis rs72901758 0.696 rs72909029 chr17:76249451 A/G cg26068271 chr17:76253126 NA 0.38 5.62 0.3 4.13e-8 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells; CRC cis rs3087591 0.887 rs2905796 chr17:29537586 G/A cg24425628 chr17:29625626 OMG;NF1 0.77 14.36 0.62 1.2e-36 Hip circumference; CRC cis rs34172651 0.917 rs7204281 chr16:24784475 C/T cg00339695 chr16:24857497 SLC5A11 0.29 6.39 0.33 5.54e-10 Intelligence (multi-trait analysis); CRC cis rs1348850 0.958 rs12471741 chr2:178448196 A/G cg02961200 chr2:178257176 LOC100130691;AGPS 0.5 7.23 0.37 3.34e-12 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs3768617 0.811 rs10911232 chr1:183052533 C/T ch.1.3577855R chr1:183094577 LAMC1 0.6 9.04 0.45 1.36e-17 Fuchs's corneal dystrophy; CRC trans rs11098499 0.954 rs3733523 chr4:120423719 C/T cg25214090 chr10:38739885 LOC399744 0.65 10.13 0.49 3.7e-21 Corneal astigmatism; CRC cis rs10256972 0.681 rs6979076 chr7:1116247 C/T cg16145915 chr7:1198662 ZFAND2A 0.37 7.09 0.36 8.48e-12 Longevity;Endometriosis; CRC cis rs801193 0.569 rs2707824 chr7:66189243 A/G cg18252515 chr7:66147081 NA -0.41 -5.82 -0.31 1.42e-8 Aortic root size; CRC cis rs6543140 0.929 rs6742530 chr2:103082280 G/A cg03938978 chr2:103052716 IL18RAP 0.41 6.53 0.34 2.51e-10 Blood protein levels; CRC cis rs644799 1.000 rs693364 chr11:95621926 A/G cg25622487 chr11:95524042 FAM76B;CEP57 0.74 11.26 0.53 4.24e-25 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs4665809 0.878 rs6748745 chr2:26364190 C/T cg22920501 chr2:26401640 FAM59B -0.58 -7.37 -0.38 1.43e-12 Gut microbiome composition (summer); CRC cis rs440932 0.798 rs330942 chr8:9020439 A/C cg06636001 chr8:8085503 FLJ10661 0.59 8.57 0.43 4.12e-16 High light scatter reticulocyte percentage of red cells; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg12243255 chr3:39194549 CSRNP1 0.45 6.29 0.33 1.01e-9 Response to antipsychotic treatment; CRC cis rs9942416 0.660 rs34905687 chr5:74997736 A/G cg19683494 chr5:74908142 NA 0.5 6.48 0.34 3.4e-10 Age-related disease endophenotypes; CRC cis rs6952808 0.698 rs11765639 chr7:1986738 G/A cg22963979 chr7:1858916 MAD1L1 -0.52 -7.12 -0.37 6.68e-12 Bipolar disorder and schizophrenia; CRC cis rs9921222 0.521 rs11649255 chr16:357140 A/G cg00101154 chr16:420108 MRPL28 -0.6 -8.03 -0.4 1.77e-14 Bone mineral density (spine);Bone mineral density; CRC cis rs875971 0.545 rs4718364 chr7:66001340 C/A cg05627663 chr7:65219948 SNORA22;CCT6P1 0.56 7.23 0.37 3.32e-12 Aortic root size; CRC cis rs67311347 0.544 rs6787516 chr3:40355616 C/T cg09455208 chr3:40491958 NA 0.31 6.06 0.32 3.74e-9 Renal cell carcinoma; CRC cis rs10504229 0.728 rs17804365 chr8:58151537 C/A cg02290350 chr8:58132656 NA -0.51 -6.57 -0.34 1.98e-10 Developmental language disorder (linguistic errors); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg22137448 chr16:2318988 RNPS1 0.41 6.24 0.33 1.36e-9 Intelligence (multi-trait analysis); CRC cis rs559928 0.606 rs57021319 chr11:63956102 G/A cg19465662 chr11:63993652 NUDT22;TRPT1 0.7 6.66 0.34 1.12e-10 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; CRC cis rs4969178 0.620 rs7219625 chr17:76390080 C/T cg05887092 chr17:76393375 PGS1 0.65 12.97 0.58 2.28e-31 HDL cholesterol levels; CRC cis rs10982256 0.567 rs11791072 chr9:117238655 C/T cg13636371 chr9:117264095 DFNB31 0.33 6.32 0.33 8.46e-10 Bipolar disorder; CRC cis rs6089584 0.888 rs2386555 chr20:60612373 C/T cg06108461 chr20:60628389 TAF4 -0.92 -15.91 -0.66 1.12e-42 Body mass index; CRC cis rs3820068 0.705 rs4646092 chr1:15821673 C/T cg27534772 chr1:16042836 PLEKHM2 0.41 6.95 0.36 1.99e-11 Systolic blood pressure; CRC cis rs9311474 0.629 rs7639267 chr3:52568805 G/T cg10802521 chr3:52805072 NEK4 -0.43 -6.66 -0.34 1.13e-10 Electroencephalogram traits; CRC cis rs910316 0.967 rs175502 chr14:75533679 A/G cg11812906 chr14:75593930 NEK9 -0.61 -9.78 -0.47 5.44e-20 Height; CRC trans rs2727020 0.729 rs2299650 chr11:49174007 A/C cg03929089 chr4:120376271 NA -0.77 -12.9 -0.58 4.46e-31 Coronary artery disease; CRC cis rs7107770 0.514 rs7938677 chr11:125072861 A/G cg27629782 chr11:125073726 PKNOX2 0.51 7.27 0.37 2.57e-12 Photic sneeze reflex; CRC cis rs2976388 0.647 rs2585138 chr8:143808951 C/T cg22687807 chr8:143858763 LYNX1 0.52 9.22 0.45 3.78e-18 Urinary tract infection frequency; CRC trans rs10504229 0.953 rs17805380 chr8:58171128 C/A cg04077850 chr5:125800366 GRAMD3 0.37 6.27 0.33 1.15e-9 Developmental language disorder (linguistic errors); CRC cis rs3858526 0.628 rs4237762 chr11:5956626 A/C cg02574844 chr11:5959923 NA -0.54 -8.61 -0.43 2.99e-16 DNA methylation (variation); CRC cis rs1143633 0.530 rs2723163 chr2:113694339 A/G cg06771106 chr2:113671356 IL1F7 -0.39 -5.7 -0.3 2.62e-8 Allergic disease (asthma, hay fever or eczema); CRC cis rs6674176 0.518 rs917294 chr1:44249485 A/G cg12908607 chr1:44402522 ARTN -0.41 -6.96 -0.36 1.82e-11 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Cognitive ability; CRC cis rs7666738 0.830 rs13124689 chr4:98961182 A/T cg05340658 chr4:99064831 C4orf37 0.61 9.45 0.46 6.55e-19 Colonoscopy-negative controls vs population controls; CRC cis rs6951245 1.000 rs80094748 chr7:1103958 G/A cg18402987 chr7:1209562 NA 0.67 7.14 0.37 5.9e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs7666738 0.830 rs36047842 chr4:99004902 C/A cg05340658 chr4:99064831 C4orf37 0.61 9.54 0.47 3.44e-19 Colonoscopy-negative controls vs population controls; CRC cis rs9549328 0.700 rs3011473 chr13:113618096 A/G cg25790453 chr13:113633590 MCF2L 0.45 7.84 0.4 6.24e-14 Systolic blood pressure; CRC cis rs2075371 1.000 rs1421484 chr7:133979795 T/C cg20476274 chr7:133979776 SLC35B4 0.82 15.29 0.64 2.97e-40 Mean platelet volume; CRC cis rs6088580 0.634 rs6087588 chr20:33066369 T/C cg24642439 chr20:33292090 TP53INP2 0.38 6.27 0.33 1.16e-9 Glomerular filtration rate (creatinine); CRC cis rs4481887 0.830 rs4916126 chr1:248466604 G/A cg13385794 chr1:248469461 NA 0.39 6.98 0.36 1.62e-11 Common traits (Other); CRC cis rs10256972 0.577 rs4999286 chr7:1199506 C/G cg07308232 chr7:1071921 C7orf50 -0.42 -5.69 -0.3 2.82e-8 Longevity;Endometriosis; CRC cis rs13108904 0.650 rs3796618 chr4:1349602 T/A cg20887711 chr4:1340912 KIAA1530 0.57 8.69 0.43 1.68e-16 Obesity-related traits; CRC trans rs8097070 0.661 rs9966711 chr18:23171413 C/G cg10708793 chr17:40264626 DHX58 0.56 6.02 0.31 4.66e-9 Systemic juvenile idiopathic arthritis; CRC cis rs9926296 0.607 rs2079672 chr16:89884917 A/G cg27121462 chr16:89883253 FANCA -0.45 -7.1 -0.36 7.84e-12 Vitiligo; CRC cis rs12760731 0.686 rs12749597 chr1:178578227 A/T cg00404053 chr1:178313656 RASAL2 0.76 7.14 0.37 6.19e-12 Obesity-related traits; CRC cis rs1799949 1.000 rs33945274 chr17:41280073 G/A cg23758822 chr17:41437982 NA 0.79 13.46 0.6 3.47e-33 Menopause (age at onset); CRC cis rs10046574 0.561 rs9656458 chr7:135202300 G/A cg27474649 chr7:135195673 CNOT4 0.66 6.21 0.32 1.58e-9 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs4665809 1.000 rs13030858 chr2:26315451 G/A cg22920501 chr2:26401640 FAM59B -0.53 -7.23 -0.37 3.4e-12 Gut microbiome composition (summer); CRC cis rs2014572 0.967 rs10411941 chr19:57762886 C/T cg24459738 chr19:57751996 ZNF805 -0.56 -8.9 -0.44 3.82e-17 Hyperactive-impulsive symptoms; CRC cis rs7412746 0.646 rs1972060 chr1:150937594 T/C cg17724175 chr1:150552817 MCL1 0.41 6.34 0.33 7.42e-10 Melanoma; CRC cis rs2075671 0.903 rs62482252 chr7:100274063 C/A cg00334542 chr7:100209784 MOSPD3 -0.57 -6.99 -0.36 1.58e-11 Other erythrocyte phenotypes; CRC cis rs853679 0.517 rs9393884 chr6:28046789 A/G cg03623178 chr6:28175578 NA 0.93 12.3 0.56 7.59e-29 Depression; CRC cis rs904251 0.561 rs4714071 chr6:37474393 C/T cg01843034 chr6:37503916 NA -0.37 -6.34 -0.33 7.43e-10 Cognitive performance; CRC cis rs644799 1.000 rs474442 chr11:95583995 A/G cg25622487 chr11:95524042 FAM76B;CEP57 0.74 11.47 0.53 7.73e-26 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs2404602 0.735 rs1607015 chr15:76702429 C/T cg03037974 chr15:76606532 NA -0.51 -7.27 -0.37 2.66e-12 Blood metabolite levels; CRC cis rs780096 0.546 rs1260320 chr2:27722416 A/G cg12648201 chr2:27665141 KRTCAP3 0.29 5.67 0.3 3.14e-8 Total body bone mineral density; CRC trans rs8002861 0.905 rs80209017 chr13:44473182 T/C cg17145862 chr1:211918768 LPGAT1 0.78 15.73 0.66 5.89e-42 Leprosy; CRC cis rs2952156 0.883 rs2517960 chr17:37846521 T/C cg11212589 chr17:38028394 ZPBP2 0.35 6.2 0.32 1.73e-9 Asthma; CRC cis rs12620999 0.555 rs10199274 chr2:238111864 G/C cg15867307 chr2:238110829 NA 0.44 7.17 0.37 4.87e-12 Systemic lupus erythematosus; CRC cis rs1757171 0.542 rs3818986 chr6:37484349 C/A cg25019722 chr6:37503610 NA -0.42 -7.43 -0.38 9.32e-13 Cognitive performance; CRC cis rs7043114 0.507 rs7037075 chr9:95216613 G/A cg14631576 chr9:95140430 CENPP -0.32 -6.11 -0.32 2.86e-9 Height; CRC cis rs1552244 1.000 rs9875081 chr3:10083935 G/A cg10729496 chr3:10149963 C3orf24 0.5 6.78 0.35 5.69e-11 Alzheimer's disease; CRC trans rs8002861 0.870 rs2121030 chr13:44444574 C/T cg17145862 chr1:211918768 LPGAT1 -0.72 -14.08 -0.61 1.45e-35 Leprosy; CRC cis rs2303759 0.709 rs2278405 chr19:49812403 A/C cg22133161 chr19:49891603 CCDC155 -0.5 -6.37 -0.33 6.41e-10 Multiple sclerosis; CRC cis rs6089584 0.888 rs6089624 chr20:60619907 C/G cg18761221 chr20:60518478 NA 0.44 7.14 0.37 5.92e-12 Body mass index; CRC cis rs1775148 1 rs1775148 chr1:205757824 C/T cg26354017 chr1:205819088 PM20D1 0.42 6.26 0.33 1.17e-9 Prostate cancer; CRC cis rs3785574 0.962 rs58131426 chr17:61854375 T/C cg25654072 chr17:61904446 PSMC5;FTSJ3 0.43 5.99 0.31 5.4e-9 Height; CRC cis rs7192380 0.964 rs55780735 chr16:69740374 A/G cg00738113 chr16:70207722 CLEC18C 0.32 5.68 0.3 2.91e-8 Sjögren's syndrome; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg24806126 chr5:14581620 FAM105A 0.39 6.08 0.32 3.42e-9 Response to antipsychotic treatment; CRC cis rs62229266 0.740 rs2835233 chr21:37393582 A/G cg08632701 chr21:37451849 NA -0.42 -6.6 -0.34 1.68e-10 Mitral valve prolapse; CRC cis rs801193 1.000 rs2659915 chr7:66153101 A/G cg05627663 chr7:65219948 SNORA22;CCT6P1 0.42 6.37 0.33 6.52e-10 Aortic root size; CRC trans rs877282 0.853 rs11596346 chr10:756673 A/T cg22713356 chr15:30763199 NA 1.19 13.88 0.61 8.17e-35 Uric acid levels; CRC cis rs9311474 0.632 rs6445528 chr3:52572447 C/T cg05573699 chr3:52720067 GNL3;PBRM1 0.38 5.6 0.3 4.48e-8 Electroencephalogram traits; CRC cis rs4594175 0.892 rs10135768 chr14:51671017 G/T cg23942311 chr14:51606299 NA 0.54 8.44 0.42 9.9e-16 Cancer; CRC cis rs9814567 0.752 rs9836401 chr3:134336897 C/T cg06109529 chr3:134205091 CEP63;ANAPC13 -0.67 -9.69 -0.47 1.11e-19 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs10946940 0.930 rs12215012 chr6:27507494 C/G cg08798685 chr6:27730294 NA 0.39 5.91 0.31 8.56e-9 Systemic lupus erythematosus; CRC cis rs28374715 0.532 rs1899 chr15:41689232 C/T cg18705301 chr15:41695430 NDUFAF1 -1.04 -18.77 -0.72 5.86e-54 Ulcerative colitis; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg17270843 chr10:99079074 FRAT1 0.3 6.25 0.33 1.26e-9 Liver disease severity in Alagille syndrome; CRC cis rs4237845 0.611 rs6581159 chr12:58323876 C/T cg02175503 chr12:58329896 NA -0.54 -7.59 -0.39 3.24e-13 Intelligence (multi-trait analysis); CRC trans rs2303319 0.504 rs62189055 chr2:162625749 C/A cg10498984 chr16:28874827 SH2B1 -0.73 -6.25 -0.33 1.3e-9 Cognitive function; CRC trans rs2303319 0.504 rs62187655 chr2:162487440 C/G cg01191114 chr3:48936118 SLC25A20 -0.68 -5.96 -0.31 6.49e-9 Cognitive function; CRC cis rs9322193 0.923 rs9505982 chr6:149939601 G/A cg00933542 chr6:150070202 PCMT1 0.3 6.36 0.33 6.66e-10 Lung cancer; CRC cis rs10540 1.000 rs71487296 chr11:500282 G/A cg19913688 chr11:428466 ANO9 -0.68 -6.98 -0.36 1.65e-11 Body mass index; CRC cis rs11098499 0.954 rs66506550 chr4:120371445 T/A cg09307838 chr4:120376055 NA 0.72 11.14 0.52 1.1e-24 Corneal astigmatism; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg09174674 chr1:9884042 CLSTN1 0.37 6.15 0.32 2.27e-9 Liver disease severity in Alagille syndrome; CRC trans rs7615952 0.599 rs6438953 chr3:125724951 T/C cg07211511 chr3:129823064 LOC729375 -0.79 -12.51 -0.57 1.27e-29 Blood pressure (smoking interaction); CRC cis rs7917772 0.546 rs10883743 chr10:104338389 T/C cg11453585 chr10:104263688 ACTR1A;SUFU 0.82 15.26 0.64 3.8e-40 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC trans rs2303319 0.504 rs1449641 chr2:162619567 T/C cg14875682 chr5:52083620 ITGA1;PELO -0.73 -6.12 -0.32 2.59e-9 Cognitive function; CRC cis rs73206853 0.764 rs28569834 chr12:110826208 T/G cg12870014 chr12:110450643 ANKRD13A 0.63 8.1 0.41 1.06e-14 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC cis rs10504229 0.683 rs2005392 chr8:58106896 T/C cg02290350 chr8:58132656 NA -0.59 -8.02 -0.4 1.88e-14 Developmental language disorder (linguistic errors); CRC cis rs9393692 0.557 rs725575 chr6:26301919 A/T cg00631329 chr6:26305371 NA -0.53 -8.86 -0.44 5.06e-17 Educational attainment; CRC cis rs11098499 0.739 rs951570 chr4:120150467 T/C cg24375607 chr4:120327624 NA -0.47 -7.88 -0.4 4.89e-14 Corneal astigmatism; CRC cis rs4144743 0.528 rs12940207 chr17:45352194 G/T cg18085866 chr17:45331354 ITGB3 -0.6 -6.61 -0.34 1.55e-10 Body mass index; CRC cis rs57590327 0.527 rs7610703 chr3:81613942 G/A cg07356753 chr3:81810745 GBE1 -0.52 -6.77 -0.35 5.78e-11 Extraversion; CRC cis rs60871478 1.000 rs62432250 chr7:801792 C/G cg13844804 chr7:814759 HEATR2 0.66 8.51 0.42 6.07e-16 Cerebrospinal P-tau181p levels; CRC cis rs765787 0.530 rs3759895 chr15:45543870 G/A cg24006582 chr15:45444508 DUOX1 -0.56 -8.45 -0.42 9.3e-16 Uric acid levels; CRC cis rs2976388 0.587 rs2717606 chr8:143799496 G/A cg12516270 chr8:143859308 LYNX1 0.43 7.56 0.38 4.03e-13 Urinary tract infection frequency; CRC cis rs17666538 0.792 rs1669715 chr8:593641 T/C cg00450029 chr8:599525 NA 0.64 5.86 0.31 1.12e-8 IgG glycosylation; CRC cis rs78663649 0.708 rs115656720 chr19:16622921 C/A cg10248733 chr19:16607483 C19orf44;CALR3 -0.85 -6.16 -0.32 2.12e-9 White blood cell count; CRC cis rs7552404 0.920 rs1612097 chr1:76218875 C/T cg10523679 chr1:76189770 ACADM 0.77 11.71 0.54 1.07e-26 Blood metabolite levels;Acylcarnitine levels; CRC cis rs672059 1.000 rs547905 chr1:183157924 G/A ch.1.3577855R chr1:183094577 LAMC1 0.51 7.25 0.37 3e-12 Hypertriglyceridemia; CRC cis rs7412746 0.658 rs6656535 chr1:150940357 G/T cg15448220 chr1:150897856 SETDB1 0.55 8.02 0.4 1.89e-14 Melanoma; CRC cis rs7044106 0.762 rs7024046 chr9:123419178 G/A cg09419670 chr9:123605666 PSMD5;LOC253039 0.69 10.76 0.51 2.41e-23 Hip circumference adjusted for BMI; CRC cis rs6502050 0.871 rs7226049 chr17:80071049 A/G cg25804541 chr17:80189381 SLC16A3 0.32 6.09 0.32 3.21e-9 Life satisfaction; CRC cis rs4563143 0.514 rs73029081 chr19:29295583 C/G cg12756686 chr19:29218302 NA 0.65 8.74 0.43 1.2e-16 Methadone dose in opioid dependence; CRC cis rs2842992 0.789 rs2295901 chr6:160201295 C/A cg11366901 chr6:160182831 ACAT2 0.96 14.12 0.61 1.02e-35 Age-related macular degeneration (geographic atrophy); CRC cis rs8170 0.603 rs10259 chr19:17430915 G/A cg04749549 chr19:17459798 NA -0.45 -7.71 -0.39 1.52e-13 Breast cancer (estrogen-receptor negative);Breast Cancer in BRCA1 mutation carriers;Ovarian cancer;Breast cancer;Epithelial ovarian cancer; CRC cis rs7107174 1.000 rs4944195 chr11:78003499 T/C cg02023728 chr11:77925099 USP35 0.52 7.45 0.38 8.29e-13 Testicular germ cell tumor; CRC cis rs208520 1.000 rs208520 chr6:66952828 G/T cg07460842 chr6:66804631 NA -0.92 -11.43 -0.53 1.04e-25 Exhaled nitric oxide output; CRC cis rs11098499 0.863 rs3775847 chr4:120447642 A/C cg09307838 chr4:120376055 NA 0.69 10.33 0.5 7.26e-22 Corneal astigmatism; CRC cis rs9443645 0.901 rs56057971 chr6:79607182 G/A cg09184832 chr6:79620586 NA -0.48 -8.96 -0.44 2.53e-17 Intelligence (multi-trait analysis); CRC cis rs1971762 0.563 rs10747678 chr12:54077687 A/C cg06632207 chr12:54070931 ATP5G2 -0.42 -7.24 -0.37 3.13e-12 Height; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg03756640 chr12:102091773 CHPT1 0.42 5.99 0.31 5.47e-9 Intelligence (multi-trait analysis); CRC cis rs10504229 0.639 rs2318146 chr8:58114873 T/G cg02290350 chr8:58132656 NA -0.58 -8.24 -0.41 4.09e-15 Developmental language disorder (linguistic errors); CRC trans rs9467711 0.659 rs13195509 chr6:26463660 C/T cg06606381 chr12:133084897 FBRSL1 -1.1 -7.57 -0.39 3.74e-13 Autism spectrum disorder or schizophrenia; CRC cis rs9419702 0.526 rs9419637 chr10:133548059 T/C cg04492858 chr10:133558786 NA 0.4 6.47 0.34 3.57e-10 Survival in rectal cancer; CRC cis rs2882667 0.858 rs13174479 chr5:138444170 G/A cg04439458 chr5:138467593 SIL1 -0.36 -6.05 -0.32 3.91e-9 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs12597458 0.763 rs3213422 chr16:72042682 A/C cg23815491 chr16:72088622 HP -0.53 -8.49 -0.42 7.27e-16 Prostate cancer; CRC cis rs4925325 0.956 rs1776263 chr20:60515820 A/G cg23262073 chr20:60523788 NA -0.59 -8.93 -0.44 3.17e-17 Obesity-related traits; CRC cis rs9926296 0.572 rs8047581 chr16:89884502 C/T cg27121462 chr16:89883253 FANCA 0.44 6.9 0.36 2.64e-11 Vitiligo; CRC cis rs1448094 0.621 rs7133309 chr12:86284078 T/C cg02569458 chr12:86230093 RASSF9 0.39 6.44 0.33 4.25e-10 Major depressive disorder; CRC cis rs72781680 0.768 rs56339558 chr2:24125234 G/A cg08917208 chr2:24149416 ATAD2B 0.55 6.71 0.35 8.44e-11 Lymphocyte counts; CRC cis rs3743162 0.553 rs4842994 chr15:85415799 A/G cg11189052 chr15:85197271 WDR73 -0.51 -6.94 -0.36 2.14e-11 Alzheimer's disease (age of onset); CRC trans rs855408 0.959 rs208994 chr6:62870244 C/T cg21737066 chr3:72495901 RYBP 0.51 6.14 0.32 2.43e-9 Epstein-Barr virus copy number in lymphoblastoid cell lines; CRC cis rs1568889 0.877 rs34351528 chr11:28304293 T/C cg06544937 chr11:28130018 METT5D1;KIF18A 0.78 9.92 0.48 1.87e-20 Bipolar disorder; CRC cis rs4073582 0.595 rs801731 chr11:65938446 G/C cg16950941 chr11:66035639 RAB1B 0.69 11.98 0.55 1.09e-27 Gout; CRC cis rs9359856 0.564 rs17506403 chr6:90499059 C/G cg13799429 chr6:90582589 CASP8AP2 -0.73 -8.01 -0.4 2.06e-14 Bipolar disorder; CRC cis rs2243480 1.000 rs160652 chr7:65538431 A/G cg25985355 chr7:65971099 NA -0.51 -5.9 -0.31 9.27e-9 Diabetic kidney disease; CRC cis rs7894051 1.000 rs11101721 chr10:135190358 C/G cg20534287 chr10:135191450 PAOX 0.68 6.25 0.33 1.25e-9 Lifespan; CRC cis rs28386778 0.897 rs8079818 chr17:61824667 C/G cg23090583 chr17:61904693 PSMC5;FTSJ3 1.05 20.15 0.74 2.12e-59 Prudent dietary pattern; CRC cis rs514406 0.861 rs35581164 chr1:53271373 C/G cg08859206 chr1:53392774 SCP2 -0.44 -6.62 -0.34 1.45e-10 Monocyte count; CRC cis rs10504229 1.000 rs59383954 chr8:58189689 G/A cg05313129 chr8:58192883 C8orf71 -0.47 -6.99 -0.36 1.49e-11 Developmental language disorder (linguistic errors); CRC cis rs2842992 0.789 rs7758895 chr6:160193465 T/C cg11366901 chr6:160182831 ACAT2 0.96 14.11 0.61 1.11e-35 Age-related macular degeneration (geographic atrophy); CRC trans rs2553218 0.690 rs8032415 chr15:54851945 A/G cg03046705 chr5:131746062 C5orf56 0.49 6.85 0.35 3.58e-11 Immune response to smallpox vaccine (IL-6); CRC cis rs1018836 0.668 rs9297857 chr8:91480964 A/C cg16814680 chr8:91681699 NA -0.65 -9.95 -0.48 1.46e-20 Ejection fraction in Tripanosoma cruzi seropositivity; CRC cis rs25422 0.938 rs62422193 chr6:118912285 G/A cg01339444 chr6:118972232 C6orf204 0.53 5.87 0.31 1.04e-8 Renal cell carcinoma; CRC cis rs13108904 0.901 rs1680073 chr4:1280337 G/A cg20092199 chr4:1342459 KIAA1530 -0.42 -7.77 -0.39 1.02e-13 Obesity-related traits; CRC cis rs10256972 0.553 rs4236381 chr7:1165723 A/C cg27094323 chr7:1216898 NA -0.4 -6.31 -0.33 9.11e-10 Longevity;Endometriosis; CRC trans rs2270927 0.510 rs7730153 chr5:75579762 A/G cg13563193 chr19:33072644 PDCD5 -0.65 -6.43 -0.33 4.6e-10 Mean corpuscular volume; CRC cis rs2294693 0.945 rs13216361 chr6:41007046 C/T cg14769373 chr6:40998127 UNC5CL -0.48 -6.12 -0.32 2.71e-9 Gastric cancer;Non-cardia gastric cancer; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg08821792 chr21:34144507 C21orf49;C21orf66 0.41 6.31 0.33 9.21e-10 Liver disease severity in Alagille syndrome; CRC trans rs9646303 0.830 rs9924961 chr16:87511467 G/A cg01301660 chr5:110886711 NA 0.57 6.23 0.32 1.43e-9 Major depressive disorder; CRC cis rs1465370 0.720 rs3823579 chr7:130017374 T/C cg03229158 chr7:130009420 NA 0.44 6.29 0.33 1.01e-9 Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction);Waist circumference adjusted for BMI in active individuals;Waist circumference adjusted for body mass index; CRC cis rs939574 1.000 rs3817424 chr2:220096903 A/T cg00496455 chr2:220118770 TUBA4A;TUBA4B 0.92 9.34 0.46 1.45e-18 Platelet distribution width; CRC trans rs116095464 0.558 rs113796397 chr5:246503 A/G cg00938859 chr5:1591904 SDHAP3 0.72 7.67 0.39 1.91e-13 Breast cancer; CRC cis rs561341 1.000 rs550923 chr17:30327013 G/C cg00745463 chr17:30367425 LRRC37B -0.88 -9.71 -0.47 9.33e-20 Hip circumference adjusted for BMI; CRC cis rs2243480 1.000 rs3885839 chr7:65290403 G/T cg25985355 chr7:65971099 NA -0.5 -5.67 -0.3 3.15e-8 Diabetic kidney disease; CRC cis rs2811415 0.597 rs9837457 chr3:127777040 G/A cg13719885 chr3:127795394 NA -0.39 -5.95 -0.31 6.69e-9 Lung function (FEV1/FVC); CRC cis rs6089584 0.888 rs6061982 chr20:60620673 C/T cg23463467 chr20:60627584 TAF4 0.33 5.68 0.3 2.91e-8 Body mass index; CRC cis rs6860806 0.507 rs183898 chr5:131716902 C/G cg18301423 chr5:131593218 PDLIM4 -0.39 -6.46 -0.34 3.7e-10 Breast cancer; CRC cis rs6545883 0.811 rs2921718 chr2:61795267 C/A cg15711740 chr2:61764176 XPO1 -0.52 -7.04 -0.36 1.13e-11 Tuberculosis; CRC cis rs972578 0.967 rs1040427 chr22:43373570 A/C cg01576275 chr22:43409880 NA 0.48 7.75 0.39 1.17e-13 Mean platelet volume; CRC cis rs4742903 0.967 rs7048372 chr9:106859738 T/C cg21169611 chr9:106856078 SMC2 0.42 5.83 0.31 1.31e-8 High-grade serous ovarian cancer;Breast cancer; CRC trans rs12310956 0.532 rs7979535 chr12:33947450 A/C cg26384229 chr12:38710491 ALG10B -0.52 -6.7 -0.35 9.09e-11 Morning vs. evening chronotype; CRC cis rs9467711 0.591 rs16891235 chr6:26017542 T/C cg08501292 chr6:25962987 TRIM38 0.85 7.85 0.4 5.77e-14 Autism spectrum disorder or schizophrenia; CRC cis rs9322193 0.923 rs9322200 chr6:149951214 G/A cg05861140 chr6:150128134 PCMT1 -0.36 -5.96 -0.31 6.46e-9 Lung cancer; CRC cis rs6088580 0.609 rs2378205 chr20:33110803 C/G cg24642439 chr20:33292090 TP53INP2 0.39 6.59 0.34 1.73e-10 Glomerular filtration rate (creatinine); CRC cis rs1055129 0.560 rs2666003 chr17:73942976 G/A cg14829360 chr17:73884958 NA -0.34 -5.72 -0.3 2.41e-8 White matter hyperintensity burden; CRC cis rs6598955 0.724 rs6656716 chr1:26563105 G/A cg04990556 chr1:26633338 UBXN11 -0.79 -13.3 -0.59 1.36e-32 Obesity-related traits; CRC cis rs9381040 0.655 rs2294696 chr6:41036988 A/G cg09580153 chr6:41068724 NFYA;LOC221442 0.44 6.45 0.33 4.1e-10 Alzheimer's disease (late onset); CRC cis rs1552244 0.882 rs17050699 chr3:10037167 G/A cg18598329 chr3:10140678 FANCD2;C3orf24 -0.81 -10.69 -0.51 4.35e-23 Alzheimer's disease; CRC trans rs1814175 0.817 rs7950856 chr11:49976394 C/T cg03929089 chr4:120376271 NA -0.98 -19.36 -0.73 2.81e-56 Height; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg23709988 chr14:23772096 PPP1R3E -0.41 -6.35 -0.33 7.03e-10 Myopia (pathological); CRC cis rs9487051 0.872 rs9487038 chr6:109610152 T/C cg12927641 chr6:109611667 NA -0.37 -6.73 -0.35 7.39e-11 Reticulocyte fraction of red cells; CRC cis rs35146811 0.696 rs1727124 chr7:99804104 T/G cg13334819 chr7:99746414 C7orf59 0.52 6.89 0.35 2.9e-11 Coronary artery disease; CRC cis rs473651 0.935 rs10170056 chr2:239339291 G/C cg18131467 chr2:239335373 ASB1 0.87 14.08 0.61 1.47e-35 Multiple system atrophy; CRC cis rs9992667 0.955 rs12499028 chr4:38639708 C/A cg19726192 chr4:38663646 FLJ13197 -0.67 -8.57 -0.43 3.95e-16 Eosinophil percentage of granulocytes; CRC trans rs4689592 0.554 rs66925245 chr4:7071999 C/T cg07817883 chr1:32538562 TMEM39B 0.64 7.18 0.37 4.78e-12 Monocyte percentage of white cells; CRC cis rs1865760 0.516 rs9379818 chr6:26023206 G/T cg16482183 chr6:26056742 HIST1H1C 0.51 7.58 0.39 3.61e-13 Height; CRC cis rs9487051 0.872 rs1111866 chr6:109610846 A/C cg21918786 chr6:109611834 NA 0.44 7.96 0.4 2.8e-14 Reticulocyte fraction of red cells; CRC trans rs2727020 0.729 rs1164685 chr11:49293660 G/A cg03929089 chr4:120376271 NA 0.83 14.4 0.62 8.26e-37 Coronary artery disease; CRC cis rs514406 0.798 rs4351588 chr1:53263826 A/T cg27535305 chr1:53392650 SCP2 0.45 8.43 0.42 1.06e-15 Monocyte count; CRC trans rs10983614 1.000 rs7867776 chr9:120072627 A/G cg06154111 chr16:89627682 RPL13;SNORD68 0.46 6.14 0.32 2.33e-9 Survival in pancreatic cancer; CRC cis rs9420 0.925 rs10896636 chr11:57448032 C/G cg23127183 chr11:57508653 C11orf31 -0.49 -6.6 -0.34 1.65e-10 Schizophrenia; CRC cis rs2075371 0.933 rs2544182 chr7:133949793 C/T cg11752832 chr7:134001865 SLC35B4 0.42 6.48 0.34 3.33e-10 Mean platelet volume; CRC cis rs7666738 0.830 rs1426672 chr4:98923984 T/C cg05340658 chr4:99064831 C4orf37 0.6 9.35 0.46 1.41e-18 Colonoscopy-negative controls vs population controls; CRC cis rs317689 0.918 rs689415 chr12:69738139 A/G cg20891283 chr12:69753455 YEATS4 -0.62 -7.86 -0.4 5.36e-14 Response to diuretic therapy; CRC cis rs7726839 0.540 rs11750321 chr5:599196 C/T cg09021430 chr5:549028 NA -0.73 -8.33 -0.42 2.19e-15 Obesity-related traits; CRC cis rs12477438 0.520 rs6542869 chr2:99783403 G/A cg26064155 chr2:99771622 LIPT1;TSGA10 0.83 14.89 0.63 1.08e-38 Chronic sinus infection; CRC cis rs12476592 0.602 rs262519 chr2:63891464 G/A cg10828910 chr2:63850056 LOC388955 0.51 6.44 0.33 4.22e-10 Childhood ear infection; CRC trans rs3733585 0.605 rs56178126 chr4:10123581 C/T cg26043149 chr18:55253948 FECH -0.53 -7.25 -0.37 3.06e-12 Cleft plate (environmental tobacco smoke interaction); CRC cis rs9287719 0.753 rs2018512 chr2:10759279 T/G cg00105475 chr2:10696890 NA 0.45 7.12 0.37 6.81e-12 Prostate cancer; CRC cis rs644799 0.710 rs12273579 chr11:95524421 G/A cg25622487 chr11:95524042 FAM76B;CEP57 0.8 13.53 0.6 1.83e-33 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs875971 0.964 rs12668936 chr7:65914404 C/T cg00343986 chr7:65444356 GUSB 0.43 6.17 0.32 1.95e-9 Aortic root size; CRC cis rs9326248 0.798 rs10892079 chr11:117016824 T/G cg20608306 chr11:116969690 SIK3 0.31 5.66 0.3 3.29e-8 Blood protein levels; CRC cis rs10927875 0.541 rs1763601 chr1:16340460 G/T cg10494257 chr1:16342123 HSPB7 0.45 6.33 0.33 7.97e-10 Dilated cardiomyopathy; CRC cis rs78456975 1.000 rs72776251 chr2:1525097 G/A cg01028140 chr2:1542097 TPO -0.58 -5.71 -0.3 2.54e-8 Placebo response in major depressive disorder (% change in symptom score); CRC cis rs9549367 0.569 rs3024719 chr13:113814225 G/A cg18105134 chr13:113819100 PROZ -0.77 -9.82 -0.48 3.82e-20 Platelet distribution width; CRC cis rs4713118 0.586 rs6905516 chr6:28086478 A/G cg12273811 chr6:28175739 NA 0.73 9.18 0.45 4.85e-18 Parkinson's disease; CRC cis rs853679 0.517 rs9393884 chr6:28046789 A/G cg15845792 chr6:28175446 NA 0.96 12.98 0.58 2.14e-31 Depression; CRC cis rs798554 1.000 rs798548 chr7:2760935 A/G cg17321639 chr7:2759063 NA -0.52 -7.43 -0.38 9.17e-13 Height; CRC cis rs2032447 0.867 rs9295683 chr6:26069495 C/T cg26028573 chr6:26043587 HIST1H2BB 0.44 6.66 0.34 1.12e-10 Intelligence (multi-trait analysis); CRC cis rs2062225 1.000 rs6542248 chr2:111753228 A/C cg11729679 chr2:111877065 BCL2L11 0.56 5.63 0.3 3.78e-8 Monocyte count; CRC cis rs1005277 0.579 rs176880 chr10:38401417 C/G cg17219203 chr10:38645113 HSD17B7P2 0.41 5.8 0.3 1.54e-8 Extrinsic epigenetic age acceleration; CRC cis rs6933660 0.646 rs9397051 chr6:151778325 C/T cg14416726 chr6:151773293 C6orf211;RMND1 -0.77 -12.83 -0.58 8.13e-31 Menarche (age at onset); CRC cis rs8078723 1.000 rs4795416 chr17:38158133 C/T cg17467752 chr17:38218738 THRA 0.73 11.82 0.55 4.15e-27 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); CRC cis rs9902453 0.730 rs4583306 chr17:28538715 C/T cg26525008 chr17:28256777 EFCAB5;SSH2 -0.48 -7.3 -0.37 2.19e-12 Coffee consumption (cups per day); CRC cis rs6968419 0.755 rs2896181 chr7:115897884 A/G cg02561103 chr7:115862891 TES 0.44 6.76 0.35 6.28e-11 Intraocular pressure; CRC cis rs2425143 0.730 rs6060626 chr20:34415073 G/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.51 -6.02 -0.31 4.78e-9 Blood protein levels; CRC cis rs2760061 0.784 rs1745414 chr1:228212159 T/A cg18477163 chr1:228402036 OBSCN 0.41 6.77 0.35 5.85e-11 Diastolic blood pressure; CRC cis rs9807989 0.801 rs10176664 chr2:102976172 G/A cg03938978 chr2:103052716 IL18RAP 0.37 6.07 0.32 3.47e-9 Asthma; CRC cis rs9527 0.637 rs7085104 chr10:104628873 A/G cg15744005 chr10:104629667 AS3MT -0.4 -8.17 -0.41 6.73e-15 Arsenic metabolism; CRC cis rs9487051 0.714 rs7755970 chr6:109602359 A/G cg21918786 chr6:109611834 NA -0.42 -7.25 -0.37 3e-12 Reticulocyte fraction of red cells; CRC cis rs2228479 0.850 rs17233448 chr16:89816424 G/T cg06656553 chr16:89960601 TCF25 -0.69 -5.74 -0.3 2.15e-8 Skin colour saturation; CRC cis rs11711311 1.000 rs9811353 chr3:113483979 G/A cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.51 -6.92 -0.36 2.41e-11 IgG glycosylation; CRC cis rs2952156 0.959 rs2934952 chr17:37832366 G/A cg11212589 chr17:38028394 ZPBP2 0.33 5.7 0.3 2.71e-8 Asthma; CRC cis rs9311676 0.656 rs11923253 chr3:58376992 G/A cg06643156 chr3:58380774 PXK 0.41 6.22 0.32 1.55e-9 Systemic lupus erythematosus; CRC cis rs3099143 0.901 rs76036665 chr15:77232720 A/G cg21673338 chr15:77095150 SCAPER -0.75 -6.1 -0.32 2.98e-9 Recalcitrant atopic dermatitis; CRC cis rs853679 0.550 rs1150689 chr6:28165099 T/C cg02683197 chr6:28174875 NA 0.88 12.35 0.56 4.59e-29 Depression; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg17351385 chr19:36505139 ALKBH6 0.47 6.54 0.34 2.3e-10 Response to antipsychotic treatment; CRC cis rs6540556 0.682 rs11119332 chr1:209892960 C/T cg05527609 chr1:210001259 C1orf107 -0.56 -6.13 -0.32 2.52e-9 Red blood cell count; CRC cis rs891088 0.660 rs10413831 chr19:7198377 C/T cg00428638 chr19:7224713 INSR -0.53 -6.73 -0.35 7.54e-11 Hip circumference adjusted for BMI;Height; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg06583696 chr2:26101536 ASXL2 0.43 6.1 0.32 2.98e-9 Response to antipsychotic treatment; CRC cis rs736408 0.609 rs2336545 chr3:52787603 C/T cg10712668 chr3:52740153 GLT8D1;SPCS1 -0.39 -5.79 -0.3 1.63e-8 Bipolar disorder; CRC trans rs9329221 0.537 rs2062332 chr8:9980024 G/A cg06636001 chr8:8085503 FLJ10661 0.47 6.88 0.35 3.05e-11 Neuroticism; CRC cis rs7493 0.755 rs13228784 chr7:94960825 A/G cg04155289 chr7:94953770 PON1 -0.55 -6.95 -0.36 1.91e-11 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs6088590 1.000 rs6088615 chr20:33400474 C/T cg08999081 chr20:33150536 PIGU -0.47 -7.9 -0.4 4.11e-14 Coronary artery disease; CRC cis rs6502050 0.799 rs34448080 chr17:80121275 A/G cg11859384 chr17:80120422 CCDC57 -0.36 -5.75 -0.3 2.06e-8 Life satisfaction; CRC cis rs9534288 0.797 rs2896951 chr13:46581185 A/G cg15192986 chr13:46630673 CPB2 -0.67 -9.85 -0.48 3.16e-20 Blood protein levels; CRC cis rs72615157 0.634 rs7789890 chr7:99800559 G/T cg16268157 chr7:99778414 STAG3 -0.43 -5.72 -0.3 2.45e-8 Lung function (FEV1/FVC); CRC cis rs7618501 0.633 rs6446193 chr3:50059758 T/C cg24308560 chr3:49941425 MST1R 0.53 8.88 0.44 4.51e-17 Intelligence (multi-trait analysis); CRC cis rs13266463 0.830 rs7014552 chr8:143410423 A/G cg16886403 chr8:143471632 TSNARE1 0.48 7.04 0.36 1.1e-11 Schizophrenia; CRC cis rs9527 0.662 rs10883783 chr10:104591152 T/A cg23093090 chr10:104574429 C10orf26 -0.41 -5.77 -0.3 1.86e-8 Arsenic metabolism; CRC cis rs7618915 0.501 rs2164885 chr3:52731269 T/C cg10802521 chr3:52805072 NEK4 -0.58 -9.15 -0.45 5.92e-18 Bipolar disorder; CRC cis rs6964587 0.869 rs6979024 chr7:91481512 T/C cg17063962 chr7:91808500 NA -0.74 -12.12 -0.56 3.45e-28 Breast cancer; CRC cis rs6502050 0.734 rs9674631 chr17:80096525 A/G cg25804541 chr17:80189381 SLC16A3 -0.31 -5.94 -0.31 7.45e-9 Life satisfaction; CRC cis rs3768617 0.565 rs7542277 chr1:183063527 C/T ch.1.3577855R chr1:183094577 LAMC1 0.84 14.39 0.62 9.24e-37 Fuchs's corneal dystrophy; CRC cis rs1153858 1.000 rs4774577 chr15:45644685 A/C cg21132104 chr15:45694354 SPATA5L1 0.59 8.71 0.43 1.49e-16 Homoarginine levels; CRC cis rs7618501 0.602 rs2301166 chr3:50148305 C/G cg05623727 chr3:50126028 RBM5 -0.44 -7.47 -0.38 7.19e-13 Intelligence (multi-trait analysis); CRC cis rs4253772 0.591 rs7291444 chr22:46656246 T/G cg03482458 chr22:46692211 CN5H6.4;GTSE1 0.52 6.58 0.34 1.88e-10 LDL cholesterol;Cholesterol, total; CRC cis rs8060686 0.641 rs79719939 chr16:68240216 A/G cg26727032 chr16:67993705 SLC12A4 -0.55 -6.31 -0.33 9.13e-10 HDL cholesterol;Metabolic syndrome; CRC cis rs727563 0.580 rs202626 chr22:41847190 C/A cg03806693 chr22:41940476 POLR3H 0.96 12.99 0.58 2.02e-31 Crohn's disease;Inflammatory bowel disease; CRC cis rs7677751 0.806 rs61320297 chr4:55088175 G/A cg00691999 chr4:55094011 PDGFRA 0.44 6.27 0.33 1.15e-9 Corneal astigmatism; CRC trans rs11098499 0.954 rs11098525 chr4:120390152 G/A cg25214090 chr10:38739885 LOC399744 0.65 10.44 0.5 3.12e-22 Corneal astigmatism; CRC cis rs13108904 0.935 rs2293633 chr4:1291640 T/C cg02018176 chr4:1364513 KIAA1530 0.41 7.01 0.36 1.39e-11 Obesity-related traits; CRC cis rs2576037 0.558 rs7244778 chr18:44541915 T/C cg19077165 chr18:44547161 KATNAL2 -0.6 -9.66 -0.47 1.38e-19 Personality dimensions; CRC cis rs7224685 0.501 rs2727064 chr17:3934101 A/G cg05562828 chr17:3906858 NA 0.66 11.71 0.54 1.03e-26 Type 2 diabetes; CRC cis rs6076065 0.723 rs6083087 chr20:23341529 C/T cg11657817 chr20:23433608 CST11 0.43 6.49 0.34 3.16e-10 Facial morphology (factor 15, philtrum width); CRC cis rs4588572 0.643 rs10043115 chr5:77692019 T/C cg11547950 chr5:77652471 NA 0.54 7.64 0.39 2.41e-13 Triglycerides; CRC cis rs2580764 0.566 rs2972075 chr2:55292322 T/G cg09592903 chr2:55203963 RTN4 0.7 11.37 0.53 1.67e-25 Mean platelet volume; CRC cis rs668210 0.793 rs619701 chr11:65772080 G/A cg02202077 chr11:65769826 EIF1AD;BANF1 -0.55 -6.99 -0.36 1.51e-11 Cerebrospinal fluid biomarker levels; CRC cis rs6496667 0.779 rs8027211 chr15:90983706 A/G cg04176472 chr15:90893244 GABARAPL3 0.58 8.2 0.41 5.58e-15 Rheumatoid arthritis; CRC cis rs4073416 0.542 rs10873191 chr14:66110628 T/C cg03016385 chr14:66212404 NA -0.45 -6.23 -0.33 1.39e-9 N-glycan levels; CRC cis rs7394190 1.000 rs7394190 chr10:75421648 G/A cg07699608 chr10:75541558 CHCHD1 0.56 6.48 0.34 3.39e-10 Incident atrial fibrillation; CRC cis rs769267 0.965 rs7254230 chr19:19434350 C/T cg03709012 chr19:19516395 GATAD2A -0.68 -10.4 -0.5 4.29e-22 Tonsillectomy; CRC cis rs2836974 0.829 rs8128191 chr21:40527311 A/G cg17971929 chr21:40555470 PSMG1 0.84 12.96 0.58 2.62e-31 Cognitive function; CRC cis rs72730918 0.564 rs1902596 chr15:51910875 A/G cg14296394 chr15:51910925 DMXL2 -0.46 -6.03 -0.32 4.49e-9 Intelligence (multi-trait analysis); CRC cis rs9302065 0.681 rs9524902 chr13:95963518 C/T cg24476569 chr13:95954382 ABCC4 -0.39 -5.91 -0.31 8.62e-9 Blood metabolite levels; CRC cis rs644799 0.562 rs1313288 chr11:95520695 T/C cg03916912 chr11:95522834 CEP57;FAM76B 0.7 11.6 0.54 2.52e-26 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs427941 0.655 rs2734782 chr7:101749667 T/C cg06246474 chr7:101738831 CUX1 0.44 6.72 0.35 8.09e-11 Plasma omega-3 polyunsaturated fatty acid level (eicosapentaenoic acid); CRC cis rs1005277 0.579 rs2008449 chr10:38414204 A/T cg25517755 chr10:38738941 LOC399744 0.43 6.3 0.33 9.39e-10 Extrinsic epigenetic age acceleration; CRC cis rs908922 0.651 rs4845442 chr1:152485545 G/A cg23254163 chr1:152506842 NA 0.46 9.04 0.45 1.41e-17 Hair morphology; CRC cis rs12230513 0.732 rs61957763 chr12:55867540 G/A cg19537932 chr12:55886519 OR6C68 -0.71 -8.93 -0.44 3.12e-17 Contrast sensitivity; CRC cis rs1552244 0.872 rs115331527 chr3:10154504 G/A cg02579736 chr3:10068473 FANCD2;CIDECP 1.05 13.79 0.61 1.81e-34 Alzheimer's disease; CRC cis rs3800461 0.544 rs6919434 chr6:34498923 C/T cg17674042 chr6:34482479 PACSIN1 -0.92 -9.2 -0.45 4.09e-18 Chronic lymphocytic leukemia; CRC cis rs4665809 0.549 rs62130460 chr2:26472718 T/C cg04944784 chr2:26401820 FAM59B 0.88 10.74 0.51 2.86e-23 Gut microbiome composition (summer); CRC cis rs1448094 0.511 rs61930035 chr12:86153695 G/A cg06740227 chr12:86229804 RASSF9 0.38 5.7 0.3 2.73e-8 Major depressive disorder; CRC cis rs4363385 0.747 rs6670614 chr1:152964338 A/G cg25856811 chr1:152973957 SPRR3 -0.26 -7.23 -0.37 3.35e-12 Inflammatory skin disease; CRC cis rs149866169 1 rs149866169 chr6:27441723 T/A cg03623178 chr6:28175578 NA 0.75 5.94 0.31 7.28e-9 Neuroticism (multi-trait analysis);Lung cancer in ever smokers;Subjective well-being (multi-trait analysis);Lung cancer;Squamous cell lung carcinoma; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg09069694 chr16:67571370 FAM65A 0.35 6.34 0.33 7.71e-10 Liver disease severity in Alagille syndrome; CRC cis rs7705042 0.865 rs6580223 chr5:141489027 G/T cg08523384 chr5:141488047 NDFIP1 -0.33 -5.84 -0.31 1.24e-8 Asthma; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg02948236 chr16:66864732 NAE1 0.4 6.15 0.32 2.25e-9 Liver disease severity in Alagille syndrome; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg13862983 chr9:73028130 KLF9 0.4 6.04 0.32 4.12e-9 Intelligence (multi-trait analysis); CRC cis rs35146811 0.844 rs12705070 chr7:99656927 A/G cg13334819 chr7:99746414 C7orf59 -0.49 -6.94 -0.36 2.04e-11 Coronary artery disease; CRC cis rs3820068 0.581 rs6669417 chr1:15922371 G/T cg24675056 chr1:15929824 NA 0.51 7.0 0.36 1.45e-11 Systolic blood pressure; CRC cis rs11690935 0.531 rs62183800 chr2:172867273 C/T cg13550731 chr2:172543902 DYNC1I2 0.61 8.8 0.44 7.61e-17 Schizophrenia; CRC cis rs7615952 0.673 rs9841194 chr3:125635739 C/T cg05084668 chr3:125655381 ALG1L -0.84 -10.45 -0.5 3.01e-22 Blood pressure (smoking interaction); CRC cis rs1552244 0.748 rs113890152 chr3:10085986 A/G cg00166722 chr3:10149974 C3orf24 0.71 9.38 0.46 1.13e-18 Alzheimer's disease; CRC cis rs2882667 0.898 rs11956089 chr5:138394604 G/T cg09476006 chr5:138032270 NA -0.45 -7.61 -0.39 2.85e-13 Age-related hearing impairment (SNP x SNP interaction); CRC trans rs208520 0.690 rs866452 chr6:66849936 A/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.02 -14.42 -0.62 6.96e-37 Exhaled nitric oxide output; CRC cis rs7927771 0.965 rs4752845 chr11:47539697 T/C cg05585544 chr11:47624801 NA -0.62 -11.39 -0.53 1.48e-25 Subjective well-being; CRC cis rs4930103 0.508 rs217205 chr11:1973205 T/C cg06197492 chr11:2016605 H19 -0.41 -6.28 -0.33 1.09e-9 DNA methylation (parent-of-origin);DNA methylation (variation); CRC cis rs2535633 0.631 rs2336670 chr3:52998504 T/G cg05573699 chr3:52720067 GNL3;PBRM1 0.39 5.64 0.3 3.65e-8 Body mass index; CRC cis rs10504229 1.000 rs113379801 chr8:58173686 C/G cg02290350 chr8:58132656 NA -0.44 -6.39 -0.33 5.52e-10 Developmental language disorder (linguistic errors); CRC cis rs2243480 1.000 rs6964530 chr7:65718851 G/C cg18252515 chr7:66147081 NA 1.25 14.41 0.62 8.1e-37 Diabetic kidney disease; CRC cis rs172166 0.694 rs536704 chr6:28092603 T/G cg06470822 chr6:28175283 NA 0.79 11.82 0.55 4.2e-27 Cardiac Troponin-T levels; CRC cis rs7824557 0.603 rs2249804 chr8:11215617 C/G cg20542592 chr8:11973495 FAM66D -0.32 -5.68 -0.3 3e-8 Retinal vascular caliber; CRC cis rs910316 0.934 rs4903278 chr14:75535019 C/A cg11812906 chr14:75593930 NEK9 0.65 10.59 0.5 9.81e-23 Height; CRC cis rs1799949 1.000 rs4534897 chr17:41431808 A/G cg19454999 chr17:41278357 BRCA1;NBR2 0.52 8.15 0.41 7.66e-15 Menopause (age at onset); CRC cis rs9322193 0.923 rs57938011 chr6:149964105 T/A cg05861140 chr6:150128134 PCMT1 -0.38 -5.92 -0.31 7.96e-9 Lung cancer; CRC cis rs8064299 0.560 rs11077763 chr17:72786029 T/C cg25054828 chr17:72772726 NAT9;TMEM104 0.85 14.33 0.62 1.53e-36 Monocyte count; CRC cis rs372883 0.600 rs1236460 chr21:30615513 G/A cg24692254 chr21:30365293 RNF160 -0.66 -9.86 -0.48 2.99e-20 Pancreatic cancer; CRC cis rs10450586 0.863 rs10767625 chr11:27304965 A/C cg10370305 chr11:27303972 NA 0.37 6.02 0.31 4.69e-9 Total body bone mineral density; CRC cis rs13108904 0.875 rs10024013 chr4:1280792 C/T cg24560729 chr4:1342394 KIAA1530 -0.32 -5.79 -0.3 1.63e-8 Obesity-related traits; CRC cis rs11229555 0.609 rs4598685 chr11:58216864 A/G cg15696309 chr11:58395628 NA -0.83 -10.55 -0.5 1.33e-22 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; CRC cis rs524281 0.861 rs7941431 chr11:65960157 C/T cg16950941 chr11:66035639 RAB1B -0.59 -7.28 -0.37 2.53e-12 Electroencephalogram traits; CRC cis rs2404602 0.647 rs11072618 chr15:77019342 A/G cg23625390 chr15:77176239 SCAPER -0.84 -12.86 -0.58 6.09e-31 Blood metabolite levels; CRC cis rs116095464 0.558 rs2288457 chr5:231270 C/T cg22857025 chr5:266934 NA -1.21 -16.57 -0.67 2.78e-45 Breast cancer; CRC trans rs6544773 0.668 rs341600 chr2:45065683 A/G cg10208897 chr5:178548229 ADAMTS2 0.35 6.03 0.32 4.4e-9 Mosquito bite size; CRC cis rs2976388 0.590 rs10110970 chr8:143820410 G/C cg22687807 chr8:143858763 LYNX1 -0.45 -7.44 -0.38 8.84e-13 Urinary tract infection frequency; CRC cis rs11212617 0.901 rs10789656 chr11:108024336 T/C cg01991180 chr11:108092276 ATM;NPAT 0.4 5.71 0.3 2.58e-8 Response to metformin in type 2 diabetes (glycemic); CRC cis rs9814567 0.806 rs4245904 chr3:134321808 G/A cg06109529 chr3:134205091 CEP63;ANAPC13 -0.68 -10.11 -0.49 4.15e-21 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC trans rs7937682 0.824 rs510866 chr11:111484113 A/C cg18187862 chr3:45730750 SACM1L 0.45 6.55 0.34 2.23e-10 Primary sclerosing cholangitis; CRC cis rs9325144 0.647 rs34963631 chr12:38912260 T/A cg13010199 chr12:38710504 ALG10B -0.4 -5.71 -0.3 2.46e-8 Morning vs. evening chronotype; CRC cis rs28829049 0.597 rs12745238 chr1:19393710 C/T cg13387374 chr1:19411106 UBR4 0.41 6.17 0.32 1.97e-9 QRS duration in Tripanosoma cruzi seropositivity; CRC cis rs9322193 0.923 rs55993747 chr6:149943152 A/G cg00933542 chr6:150070202 PCMT1 0.32 6.5 0.34 3.06e-10 Lung cancer; CRC cis rs7208859 0.623 rs9898084 chr17:29082334 C/G cg13385521 chr17:29058706 SUZ12P 0.7 8.1 0.41 1.05e-14 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs875971 1.000 rs9986696 chr7:65704576 C/A cg12463550 chr7:65579703 CRCP -0.48 -6.94 -0.36 2.06e-11 Aortic root size; CRC cis rs6089584 0.566 rs2146852 chr20:60616492 T/G cg06108461 chr20:60628389 TAF4 -0.78 -12.98 -0.58 2.25e-31 Body mass index; CRC cis rs6088580 0.634 rs6059880 chr20:33088669 G/A cg08999081 chr20:33150536 PIGU 0.63 11.62 0.54 2.11e-26 Glomerular filtration rate (creatinine); CRC cis rs4731207 0.564 rs2127972 chr7:124665545 A/T cg23710748 chr7:124431027 NA -0.4 -6.3 -0.33 9.7e-10 Cutaneous malignant melanoma; CRC cis rs853679 0.517 rs7755442 chr6:28039015 T/C cg03623178 chr6:28175578 NA 0.93 12.17 0.56 2.25e-28 Depression; CRC cis rs7618915 0.547 rs34215106 chr3:52659124 T/C cg18099408 chr3:52552593 STAB1 -0.43 -7.1 -0.36 7.92e-12 Bipolar disorder; CRC cis rs7072216 0.881 rs6584192 chr10:100152373 T/G cg26618903 chr10:100175079 PYROXD2 -0.37 -6.26 -0.33 1.22e-9 Metabolite levels; CRC cis rs1524976 0.943 rs62255325 chr3:65509446 T/A cg16238336 chr3:65465873 MAGI1 -0.46 -5.99 -0.31 5.57e-9 PR interval; CRC cis rs7191439 0.657 rs3826076 chr16:88780518 C/T cg02389323 chr16:88786976 FAM38A -0.81 -8.07 -0.41 1.31e-14 Plateletcrit; CRC cis rs7131987 1.000 rs7131987 chr12:29406488 G/T cg09582351 chr12:29534625 ERGIC2 -0.28 -5.84 -0.31 1.25e-8 QT interval; CRC cis rs7552404 0.921 rs10873685 chr1:76218818 A/C cg22875332 chr1:76189707 ACADM 0.71 9.67 0.47 1.29e-19 Blood metabolite levels;Acylcarnitine levels; CRC cis rs2836974 0.831 rs6517521 chr21:40551588 A/G cg17971929 chr21:40555470 PSMG1 0.82 11.69 0.54 1.28e-26 Cognitive function; CRC cis rs17767392 1.000 rs17767523 chr14:71880739 G/C cg13720639 chr14:72061746 SIPA1L1 -0.55 -6.95 -0.36 1.96e-11 Mitral valve prolapse; CRC cis rs11212617 0.967 rs7110127 chr11:108329125 A/G cg01991180 chr11:108092276 ATM;NPAT 0.4 5.76 0.3 1.96e-8 Response to metformin in type 2 diabetes (glycemic); CRC cis rs7264396 0.563 rs2425146 chr20:34355268 G/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.45 -6.47 -0.34 3.64e-10 Total cholesterol levels; CRC cis rs10504073 0.584 rs74457150 chr8:49890753 C/G cg00325661 chr8:49890786 NA 0.63 11.47 0.53 7.59e-26 Blood metabolite ratios; CRC cis rs2652822 1.000 rs1126309 chr15:63429062 A/G cg02713581 chr15:63449717 RPS27L 0.39 5.72 0.3 2.41e-8 Metabolic traits; CRC cis rs561341 0.883 rs7219239 chr17:30212016 A/G cg19193384 chr17:30244184 NA 0.47 5.81 0.31 1.47e-8 Hip circumference adjusted for BMI; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg18255008 chr19:11908503 ZNF491 0.42 6.32 0.33 8.51e-10 Intelligence (multi-trait analysis); CRC cis rs6460942 0.915 rs62448623 chr7:12464122 A/G cg06484146 chr7:12443880 VWDE -0.78 -8.1 -0.41 1.11e-14 Coronary artery disease; CRC cis rs3617 0.625 rs7652667 chr3:52866535 C/A cg07507251 chr3:52567010 NT5DC2 -0.4 -6.2 -0.32 1.71e-9 Red blood cell count;Autism spectrum disorder or schizophrenia; CRC cis rs1536827 0.748 rs9418986 chr10:135324276 T/C cg20169779 chr10:135381914 SYCE1 0.5 6.01 0.31 4.9e-9 Visceral adipose tissue/subcutaneous adipose tissue ratio; CRC trans rs6598955 0.627 rs6684875 chr1:26567044 A/G cg07461501 chr17:79650226 HGS;ARL16 -0.51 -6.01 -0.31 4.85e-9 Obesity-related traits; CRC cis rs713477 0.654 rs7143800 chr14:55917734 A/G cg21836586 chr14:55907198 TBPL2 0.34 6.18 0.32 1.91e-9 Pediatric bone mineral content (femoral neck); CRC cis rs10979 1.000 rs1416205 chr6:143889397 T/C cg25407410 chr6:143891975 LOC285740 -0.82 -13.4 -0.59 5.5e-33 Hypospadias; CRC cis rs4665809 0.590 rs2384361 chr2:26452209 T/C cg25036284 chr2:26402008 FAM59B -0.61 -7.77 -0.39 1.01e-13 Gut microbiome composition (summer); CRC cis rs4481887 0.893 rs4512685 chr1:248446246 C/T cg13385794 chr1:248469461 NA 0.38 6.65 0.34 1.24e-10 Common traits (Other); CRC cis rs12540874 0.759 rs12718572 chr7:50573325 C/T cg18232548 chr7:50535776 DDC -0.5 -7.41 -0.38 1.08e-12 Systemic sclerosis; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg21830413 chr10:70884251 VPS26A 0.43 6.05 0.32 3.85e-9 Anxiety disorder; CRC cis rs4713118 0.527 rs9461433 chr6:28095172 C/T cg02631126 chr6:28058918 ZSCAN12L1 0.29 5.89 0.31 9.41e-9 Parkinson's disease; CRC cis rs67311347 1.000 rs9874499 chr3:40441908 C/T cg24209194 chr3:40518798 ZNF619 0.41 6.12 0.32 2.63e-9 Renal cell carcinoma; CRC cis rs3796352 1.000 rs33999310 chr3:52883332 G/A cg07884673 chr3:53033167 SFMBT1 0.74 5.98 0.31 5.73e-9 Immune reponse to smallpox (secreted IL-2); CRC cis rs2153535 0.541 rs1414347 chr6:8471831 T/C cg21535247 chr6:8435926 SLC35B3 0.51 7.76 0.39 1.11e-13 Motion sickness; CRC cis rs4665809 0.590 rs962217 chr2:26438276 T/C cg22920501 chr2:26401640 FAM59B -0.85 -12.1 -0.55 3.96e-28 Gut microbiome composition (summer); CRC cis rs7517126 0.688 rs73080175 chr1:196937331 G/A cg13682187 chr1:196946512 CFHR5 -0.45 -5.87 -0.31 1.08e-8 Blood protein levels; CRC cis rs7493 1.000 rs1034809 chr7:95051652 G/A cg21856205 chr7:94953877 PON1 -0.5 -6.49 -0.34 3.25e-10 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs910316 0.523 rs4026175 chr14:75502240 C/A cg03030879 chr14:75389066 RPS6KL1 -0.58 -8.73 -0.43 1.26e-16 Height; CRC cis rs7589728 0.514 rs74426843 chr2:88459388 C/T cg04511125 chr2:88470314 THNSL2 0.82 8.7 0.43 1.59e-16 Plasma clusterin levels; CRC cis rs9911578 0.967 rs4076229 chr17:56937256 C/T cg05425664 chr17:57184151 TRIM37 -0.49 -7.72 -0.39 1.45e-13 Intelligence (multi-trait analysis); CRC cis rs12983728 0.505 rs35511051 chr19:58665817 C/A cg24884572 chr19:58661833 ZNF329 0.45 5.64 0.3 3.65e-8 Cholesterol, total; CRC cis rs2576037 0.583 rs892586 chr18:44560429 C/A cg07643061 chr18:44555308 TCEB3C;TCEB3CL;KATNAL2 0.35 5.85 0.31 1.16e-8 Personality dimensions; CRC cis rs9914988 0.943 rs1035989 chr17:27143810 T/G cg16670446 chr17:27188758 MIR451;MIR144 0.53 8.4 0.42 1.32e-15 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs2952156 1.000 rs2934971 chr17:37854507 G/T cg20243544 chr17:37824526 PNMT 0.56 8.62 0.43 2.83e-16 Asthma; CRC cis rs898097 0.756 rs11655103 chr17:80813467 T/C cg15664640 chr17:80829946 TBCD -0.69 -11.77 -0.54 6.24e-27 Breast cancer; CRC cis rs9916302 0.706 rs4795358 chr17:37573065 A/C cg07936489 chr17:37558343 FBXL20 -0.93 -11.84 -0.55 3.62e-27 Glomerular filtration rate (creatinine); CRC trans rs7395662 0.517 rs11039885 chr11:48647107 A/G cg00717180 chr2:96193071 NA -0.37 -6.11 -0.32 2.81e-9 HDL cholesterol; CRC cis rs478304 0.654 rs10896035 chr11:65461160 G/A cg05805236 chr11:65401703 PCNXL3 -0.42 -6.65 -0.34 1.19e-10 Acne (severe); CRC cis rs8141529 0.732 rs2347447 chr22:29179739 C/A cg15103426 chr22:29168792 CCDC117 0.61 8.84 0.44 5.88e-17 Lymphocyte counts; CRC cis rs7605827 0.780 rs34739027 chr2:15532146 C/A cg19274914 chr2:15703543 NA 0.38 5.61 0.3 4.27e-8 Educational attainment (years of education); CRC cis rs7264396 0.563 rs2425079 chr20:34298191 T/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.48 -6.67 -0.35 1.06e-10 Total cholesterol levels; CRC cis rs12908161 0.853 rs11633788 chr15:85305142 T/A cg17507749 chr15:85114479 UBE2QP1 0.52 7.68 0.39 1.82e-13 Schizophrenia; CRC cis rs2304069 0.954 rs6579767 chr5:149406271 C/T cg22760475 chr5:149380129 HMGXB3;TIGD6 0.91 10.43 0.5 3.42e-22 HIV-1 control; CRC cis rs9457247 0.756 rs2345572 chr6:167403441 A/T cg23791538 chr6:167370224 RNASET2 -0.38 -5.88 -0.31 1e-8 Crohn's disease; CRC trans rs8002861 0.665 rs2065926 chr13:44422371 A/G cg17145862 chr1:211918768 LPGAT1 -0.49 -8.11 -0.41 1.04e-14 Leprosy; CRC cis rs9976767 0.861 rs9974339 chr21:43838054 T/C cg23042151 chr21:43824109 UBASH3A -0.33 -5.88 -0.31 1.02e-8 Type 1 diabetes; CRC cis rs9858542 0.953 rs11713474 chr3:49611457 A/G cg07274523 chr3:49395745 GPX1 0.47 6.11 0.32 2.77e-9 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs10927875 0.722 rs6660685 chr1:16346988 A/G cg10494257 chr1:16342123 HSPB7 0.44 5.77 0.3 1.85e-8 Dilated cardiomyopathy; CRC cis rs870825 0.616 rs7659101 chr4:185632158 C/T cg04058563 chr4:185651563 MLF1IP 0.73 9.35 0.46 1.38e-18 Blood protein levels; CRC cis rs3924048 0.574 rs11121931 chr1:12617009 G/A cg23650765 chr1:12612165 NA 0.35 6.62 0.34 1.48e-10 Optic cup area; CRC cis rs7216064 0.954 rs4790973 chr17:65951133 C/T cg12091567 chr17:66097778 LOC651250 -0.63 -7.3 -0.37 2.18e-12 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CRC cis rs910316 1.000 rs10142626 chr14:75555636 A/T cg03030879 chr14:75389066 RPS6KL1 -0.46 -7.33 -0.37 1.8e-12 Height; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg23359706 chr19:11491839 EPOR 0.43 6.2 0.32 1.66e-9 Intelligence (multi-trait analysis); CRC cis rs172166 0.516 rs2791333 chr6:28111114 A/G cg02683197 chr6:28174875 NA 0.47 6.66 0.34 1.15e-10 Cardiac Troponin-T levels; CRC trans rs9291683 1.000 rs9291683 chr4:10324160 C/T cg26043149 chr18:55253948 FECH 0.49 7.67 0.39 1.93e-13 Bone mineral density; CRC cis rs738322 0.574 rs738323 chr22:38569527 C/T cg25457927 chr22:38595422 NA -0.31 -5.88 -0.31 1.01e-8 Cutaneous nevi; CRC cis rs10504229 0.683 rs35244711 chr8:58117762 T/G cg04204079 chr8:58130323 NA -0.45 -5.78 -0.3 1.71e-8 Developmental language disorder (linguistic errors); CRC cis rs9894429 1.000 rs4074915 chr17:79579230 G/A cg13777783 chr17:79615861 NA 0.3 5.72 0.3 2.44e-8 Eye color traits; CRC cis rs1983170 0.935 rs578155 chr1:91976541 G/A cg02896835 chr1:92012615 NA -0.48 -6.25 -0.33 1.27e-9 Eosinophil percentage of white cells; CRC cis rs501120 0.657 rs1619661 chr10:44733383 T/C cg09554077 chr10:44749378 NA 0.64 7.06 0.36 9.84e-12 Coronary artery disease;Coronary heart disease; CRC cis rs6427782 0.602 rs9782959 chr1:199821515 G/A cg07208853 chr1:200005219 NR5A2 0.23 6.09 0.32 3.13e-9 Menarche (age at onset); CRC cis rs651907 0.535 rs17412601 chr3:101499275 T/C cg11279151 chr3:101281821 RG9MTD1 -0.52 -7.04 -0.36 1.15e-11 Colorectal cancer; CRC trans rs944990 0.595 rs10123378 chr9:96375217 C/T cg12648201 chr2:27665141 KRTCAP3 0.3 6.03 0.32 4.49e-9 Body mass index; CRC cis rs3733585 0.699 rs6449157 chr4:9960442 G/A cg00071950 chr4:10020882 SLC2A9 -0.55 -9.92 -0.48 1.83e-20 Cleft plate (environmental tobacco smoke interaction); CRC trans rs9813712 0.574 rs35856399 chr3:129960804 C/T cg23942268 chr17:6347992 FAM64A -0.41 -6.01 -0.31 5.05e-9 Response to amphetamines; CRC cis rs10905065 0.965 rs7100576 chr10:5784649 G/A cg11519256 chr10:5708881 ASB13 0.53 7.83 0.4 6.73e-14 Menopause (age at onset); CRC cis rs2749592 0.531 rs10764134 chr10:37856660 T/C cg00409905 chr10:38381863 ZNF37A 0.59 9.38 0.46 1.08e-18 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs1387259 0.690 rs1601985 chr12:48761914 A/G cg21466736 chr12:48725269 NA -0.54 -7.92 -0.4 3.66e-14 Obstructive sleep apnea trait (apnea hypopnea index); CRC cis rs4481887 0.927 rs12042598 chr1:248482016 C/T cg00666640 chr1:248458726 OR2T12 0.46 7.97 0.4 2.59e-14 Common traits (Other); CRC cis rs7666738 0.830 rs7661264 chr4:98961574 G/A cg17366294 chr4:99064904 C4orf37 0.43 7.36 0.38 1.49e-12 Colonoscopy-negative controls vs population controls; CRC cis rs2227564 0.729 rs2688616 chr10:75650652 G/C cg00564723 chr10:75632066 CAMK2G -0.33 -7.63 -0.39 2.58e-13 Crohn's disease;Inflammatory bowel disease; CRC cis rs9322817 0.691 rs9486015 chr6:105254000 C/T cg02098413 chr6:105308735 HACE1 -0.44 -8.6 -0.43 3.29e-16 Thyroid stimulating hormone; CRC cis rs62064224 0.902 rs17732573 chr17:30627664 C/T cg09324608 chr17:30823087 MYO1D -0.4 -6.79 -0.35 5.14e-11 Schizophrenia; CRC cis rs459571 0.920 rs455073 chr9:136909141 G/C cg13789015 chr9:136890014 NCRNA00094 0.45 5.83 0.31 1.32e-8 Platelet distribution width; CRC cis rs6570726 0.738 rs4495284 chr6:145916617 T/A cg23711669 chr6:146136114 FBXO30 0.75 12.86 0.58 6.3e-31 Lobe attachment (rater-scored or self-reported); CRC cis rs7927592 0.913 rs12283755 chr11:68371658 A/G cg16797656 chr11:68205561 LRP5 0.38 5.9 0.31 9.09e-9 Total body bone mineral density; CRC cis rs554111 0.656 rs10799682 chr1:21424030 G/C cg02927042 chr1:21476669 EIF4G3 0.37 5.6 0.3 4.51e-8 Facial morphology (factor 17, height of vermillion upper lip); CRC cis rs7781266 0.793 rs57352738 chr7:133304694 T/A cg03336402 chr7:133662267 EXOC4 0.46 5.62 0.3 4.05e-8 Educational attainment (college completion); CRC cis rs1799949 0.896 rs33933393 chr17:41317432 C/T cg23758822 chr17:41437982 NA 0.8 13.62 0.6 8.36e-34 Menopause (age at onset); CRC cis rs1881396 0.531 rs76586169 chr2:27897835 G/A cg27432699 chr2:27873401 GPN1 0.58 6.45 0.34 3.93e-10 Nonalcoholic fatty liver disease; CRC cis rs35306767 0.807 rs34527494 chr10:935192 T/C cg26597838 chr10:835615 NA 1.23 14.5 0.62 3.54e-37 Eosinophil percentage of granulocytes; CRC cis rs8180040 0.654 rs9837343 chr3:47177388 C/T cg10298567 chr3:47292165 KIF9 -0.37 -5.7 -0.3 2.6e-8 Colorectal cancer; CRC cis rs7727544 0.606 rs200838 chr5:131710399 A/C cg12564285 chr5:131593104 PDLIM4 -0.34 -6.28 -0.33 1.09e-9 Blood metabolite levels; CRC cis rs6831352 0.918 rs1042365 chr4:100045500 G/T cg12011299 chr4:100065546 ADH4 -0.51 -9.71 -0.47 9.34e-20 Alcohol dependence; CRC cis rs1550582 0.662 rs6981748 chr8:135501309 A/C cg17885191 chr8:135476712 NA -0.95 -12.54 -0.57 9.07e-30 Educational attainment; CRC trans rs877282 0.898 rs12358513 chr10:757571 A/G cg22713356 chr15:30763199 NA 1.24 14.62 0.63 1.19e-37 Uric acid levels; CRC cis rs4601821 0.823 rs17115439 chr11:113264272 T/C cg14159747 chr11:113255604 NA 0.51 10.05 0.48 6.83e-21 Alcoholic chronic pancreatitis; CRC cis rs2243480 1.000 rs1546059 chr7:65654709 C/A cg18252515 chr7:66147081 NA 1.28 14.8 0.63 2.39e-38 Diabetic kidney disease; CRC cis rs1997103 0.705 rs56301138 chr7:55396555 G/T cg17469321 chr7:55412551 NA 0.74 11.38 0.53 1.54e-25 QRS interval (sulfonylurea treatment interaction); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg07312556 chr10:61666263 CCDC6 0.34 6.05 0.32 3.94e-9 Liver disease severity in Alagille syndrome; CRC cis rs3733585 0.648 rs7376155 chr4:9952588 C/T cg00071950 chr4:10020882 SLC2A9 -0.55 -9.74 -0.47 7.09e-20 Cleft plate (environmental tobacco smoke interaction); CRC cis rs2506889 0.553 rs11580264 chr1:10605796 C/A cg17425144 chr1:10567563 PEX14 0.55 12.54 0.57 9.14e-30 Breast cancer; CRC cis rs250677 0.652 rs1422582 chr5:148436925 T/C cg18129178 chr5:148520854 ABLIM3 -0.41 -5.98 -0.31 5.84e-9 Breast cancer; CRC cis rs9491140 0.539 rs10872287 chr6:124694573 T/G cg05308643 chr6:124982296 NKAIN2 0.56 7.02 0.36 1.29e-11 Neuroticism; CRC cis rs745570 0.833 rs1696757 chr17:77800743 C/T cg04986373 chr17:77768687 CBX8 -0.38 -5.94 -0.31 7.17e-9 Breast cancer; CRC trans rs867371 0.502 rs7176926 chr15:82538094 A/G cg04831495 chr15:85060580 GOLGA6L5 -0.38 -6.05 -0.32 3.92e-9 Cognitive ability;Cognitive ability (multi-trait analysis); CRC cis rs3796352 1.000 rs13069006 chr3:52973305 G/C cg06204229 chr3:52865917 ITIH4 0.5 5.74 0.3 2.19e-8 Immune reponse to smallpox (secreted IL-2); CRC cis rs9814567 0.806 rs7626557 chr3:134318213 A/G cg06109529 chr3:134205091 CEP63;ANAPC13 -0.68 -10.11 -0.49 4.15e-21 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs6860806 0.507 rs156322 chr5:131653925 C/T cg18301423 chr5:131593218 PDLIM4 0.37 6.06 0.32 3.79e-9 Breast cancer; CRC cis rs965469 0.724 rs6051818 chr20:3362033 T/C cg25506879 chr20:3388711 C20orf194 -0.37 -5.73 -0.3 2.22e-8 IFN-related cytopenia; CRC cis rs6504622 0.557 rs7225428 chr17:45000997 G/A cg16759221 chr17:45003025 GOSR2 0.6 9.66 0.47 1.39e-19 Orofacial clefts; CRC cis rs3790645 0.831 rs873151 chr1:26880989 T/C cg23229016 chr1:26872525 RPS6KA1 0.28 6.43 0.33 4.47e-10 Glucose homeostasis traits; CRC cis rs4713118 0.955 rs9368528 chr6:27683798 G/A cg25164649 chr6:28176230 NA 0.54 7.3 0.37 2.13e-12 Parkinson's disease; CRC trans rs5756813 0.688 rs8140207 chr22:38130459 G/T cg19894588 chr14:64061835 NA -0.59 -7.75 -0.39 1.19e-13 Optic cup area;Vertical cup-disc ratio; CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg15412250 chr17:21828178 NA -0.36 -6.21 -0.32 1.59e-9 Obesity-related traits; CRC cis rs9910055 0.762 rs6503489 chr17:42246289 G/A cg19774624 chr17:42201019 HDAC5 -0.67 -10.25 -0.49 1.41e-21 Total body bone mineral density; CRC cis rs10883723 0.738 rs3781290 chr10:104244948 G/C cg22532475 chr10:104410764 TRIM8 -0.36 -6.47 -0.34 3.52e-10 Allergic disease (asthma, hay fever or eczema); CRC cis rs17095355 1.000 rs921348 chr10:111707498 A/G cg00817464 chr10:111662876 XPNPEP1 -0.62 -8.21 -0.41 5.08e-15 Biliary atresia; CRC cis rs6964587 1.000 rs756647 chr7:91586389 A/G cg17063962 chr7:91808500 NA 0.8 14.06 0.61 1.68e-35 Breast cancer; CRC cis rs7617773 0.962 rs6797587 chr3:48197614 A/G cg11946769 chr3:48343235 NME6 -0.52 -6.86 -0.35 3.49e-11 Coronary artery disease; CRC cis rs6484504 0.576 rs16922084 chr11:31371109 C/T cg14844989 chr11:31128820 NA 0.35 6.07 0.32 3.58e-9 Red blood cell count; CRC cis rs55788414 0.932 rs4365300 chr16:81184460 C/T cg06400318 chr16:81190750 PKD1L2 -0.59 -6.76 -0.35 6.2e-11 Left ventricular obstructive tract defect (maternal effect); CRC cis rs1223397 0.651 rs2458310 chr6:13310308 G/C cg07912922 chr6:13274314 PHACTR1 0.39 6.07 0.32 3.52e-9 Blood pressure; CRC cis rs4474465 0.790 rs4945290 chr11:78252249 C/T cg27205649 chr11:78285834 NARS2 0.53 6.82 0.35 4.31e-11 Alzheimer's disease (survival time); CRC cis rs910316 0.839 rs35977276 chr14:75637359 A/C cg11812906 chr14:75593930 NEK9 -0.61 -9.33 -0.46 1.58e-18 Height; CRC cis rs427943 0.750 rs8133307 chr21:46599714 C/T cg19498844 chr21:46707878 POFUT2;LOC642852 0.43 5.76 0.3 1.92e-8 Body mass index; CRC cis rs6570726 0.791 rs11155432 chr6:145898761 T/C cg05347473 chr6:146136440 FBXO30 0.38 5.86 0.31 1.15e-8 Lobe attachment (rater-scored or self-reported); CRC cis rs2952156 0.920 rs2517958 chr17:37838751 G/A cg00129232 chr17:37814104 STARD3 -0.72 -12.88 -0.58 5.11e-31 Asthma; CRC cis rs8072100 0.713 rs4968257 chr17:45430534 A/G cg08085267 chr17:45401833 C17orf57 -0.6 -9.44 -0.46 7.22e-19 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs9372498 0.536 rs12333080 chr6:118845410 A/C cg24463073 chr6:118973353 C6orf204 0.52 6.97 0.36 1.69e-11 Diastolic blood pressure; CRC cis rs8141529 0.732 rs5762788 chr22:29174770 G/T cg02153584 chr22:29168773 CCDC117 0.54 8.38 0.42 1.56e-15 Lymphocyte counts; CRC cis rs11690935 0.959 rs10204622 chr2:172588982 C/T cg13550731 chr2:172543902 DYNC1I2 -1.1 -18.58 -0.72 3.5e-53 Schizophrenia; CRC cis rs2204008 0.594 rs11531211 chr12:37998007 T/G cg26384229 chr12:38710491 ALG10B -0.64 -9.86 -0.48 2.97e-20 Bladder cancer; CRC cis rs7089973 0.604 rs7919649 chr10:116609576 T/C cg23260525 chr10:116636907 FAM160B1 0.35 8.1 0.41 1.05e-14 Bipolar disorder or attention deficit hyperactivity disorder; CRC cis rs7412746 0.611 rs4970984 chr1:150887377 T/C cg10589385 chr1:150898437 SETDB1 0.27 5.92 0.31 7.89e-9 Melanoma; CRC cis rs4638749 0.654 rs6761157 chr2:108816885 A/C cg25838818 chr2:108905173 SULT1C2 -0.34 -5.79 -0.3 1.68e-8 Blood pressure; CRC cis rs1129187 0.755 rs3293 chr6:42938377 G/T cg10862848 chr6:42927986 GNMT -0.39 -9.42 -0.46 8.3e-19 Alzheimer's disease in APOE e4+ carriers; CRC cis rs6502050 0.761 rs7225637 chr17:80059758 A/G cg25804541 chr17:80189381 SLC16A3 -0.33 -6.2 -0.32 1.68e-9 Life satisfaction; CRC trans rs3942852 0.955 rs6485809 chr11:48112468 C/T cg03929089 chr4:120376271 NA -0.57 -6.46 -0.34 3.86e-10 Acute lymphoblastic leukemia (childhood); CRC cis rs6502050 0.769 rs9916231 chr17:80119645 A/G cg19223190 chr17:80058835 NA 0.39 6.19 0.32 1.82e-9 Life satisfaction; CRC cis rs9733 0.565 rs7524620 chr1:150616699 C/T cg18016565 chr1:150552671 MCL1 -0.43 -6.27 -0.33 1.13e-9 Tonsillectomy; CRC cis rs1320333 0.772 rs35181861 chr2:679483 A/G cg00500140 chr2:691012 NA 0.63 6.71 0.35 8.7e-11 Obesity-related traits; CRC cis rs10751667 0.580 rs7396041 chr11:1001607 G/A ch.11.42038R chr11:967971 AP2A2 0.57 9.1 0.45 9.09e-18 Alzheimer's disease (late onset); CRC trans rs7726839 0.574 rs72705017 chr5:623733 G/A cg25482853 chr8:67687455 SGK3 1.11 12.99 0.58 2.06e-31 Obesity-related traits; CRC trans rs7615952 0.609 rs13088451 chr3:125553499 G/C cg07211511 chr3:129823064 LOC729375 -0.95 -13.86 -0.61 9.81e-35 Blood pressure (smoking interaction); CRC cis rs995000 0.931 rs6587976 chr1:62945631 C/T cg19896129 chr1:63156450 NA 0.41 6.2 0.32 1.68e-9 Triglyceride levels; CRC cis rs938554 0.784 rs7439210 chr4:9971749 C/G cg00071950 chr4:10020882 SLC2A9 -0.45 -6.21 -0.32 1.57e-9 Blood metabolite levels; CRC cis rs9902453 0.845 rs12452201 chr17:28214173 G/C cg26525008 chr17:28256777 EFCAB5;SSH2 0.57 8.63 0.43 2.7e-16 Coffee consumption (cups per day); CRC cis rs12042938 0.935 rs1094653 chr1:231794794 C/A cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX 0.47 6.69 0.35 9.63e-11 Neuranatomic and neurocognitive phenotypes; CRC cis rs1008375 1.000 rs6449319 chr4:17640283 T/A cg04450456 chr4:17643702 FAM184B 0.37 5.9 0.31 8.95e-9 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs344364 0.511 rs1657133 chr16:1950300 A/G cg14074117 chr16:1909714 C16orf73 0.41 5.66 0.3 3.28e-8 Glomerular filtration rate in chronic kidney disease; CRC cis rs7666738 0.962 rs13147921 chr4:99069296 C/G cg03676636 chr4:99064102 C4orf37 0.22 5.85 0.31 1.17e-8 Colonoscopy-negative controls vs population controls; CRC cis rs7474896 0.561 rs2474603 chr10:38445682 C/T cg25427524 chr10:38739819 LOC399744 -0.52 -5.78 -0.3 1.72e-8 Obesity (extreme); CRC cis rs10089 1.000 rs4836367 chr5:127482592 A/G cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.74 10.4 0.5 4.25e-22 Ileal carcinoids; CRC cis rs936229 0.861 rs11634474 chr15:75116184 C/G cg14664628 chr15:75095509 CSK -1.02 -19.76 -0.74 7.22e-58 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); CRC cis rs10751667 0.961 rs6421967 chr11:983966 T/C cg23136738 chr11:925521 AP2A2 -0.51 -8.36 -0.42 1.84e-15 Alzheimer's disease (late onset); CRC cis rs916888 0.821 rs199512 chr17:44857352 T/C cg01570182 chr17:44337453 NA -1.07 -12.8 -0.58 9.93e-31 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs4713118 0.568 rs9468213 chr6:27706180 G/A cg20933634 chr6:27740509 NA 0.44 6.44 0.33 4.32e-10 Parkinson's disease; CRC trans rs7618501 0.633 rs4688757 chr3:50035323 T/C cg21659725 chr3:3221576 CRBN 0.61 9.59 0.47 2.31e-19 Intelligence (multi-trait analysis); CRC cis rs6547741 1.000 rs13026621 chr2:27807624 G/A cg27432699 chr2:27873401 GPN1 0.77 13.64 0.6 7.11e-34 Oral cavity cancer; CRC cis rs13191362 0.872 rs13206549 chr6:162978032 T/G cg06582575 chr6:163149167 PACRG;PARK2 0.8 10.02 0.48 8.46e-21 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs250677 0.687 rs250664 chr5:148453823 C/T cg23229984 chr5:148520753 ABLIM3 0.5 6.93 0.36 2.16e-11 Breast cancer; CRC cis rs9549367 0.789 rs12866090 chr13:113869410 G/A cg18105134 chr13:113819100 PROZ -0.7 -10.27 -0.49 1.25e-21 Platelet distribution width; CRC cis rs2933343 1.000 rs1683782 chr3:128640277 A/G cg11901034 chr3:128598214 ACAD9 -0.51 -6.32 -0.33 8.5e-10 IgG glycosylation; CRC cis rs7833790 0.963 rs1451997 chr8:82774053 A/T cg27398817 chr8:82754497 SNX16 0.51 6.19 0.32 1.79e-9 Diastolic blood pressure; CRC cis rs1865760 0.566 rs10807006 chr6:26048752 C/A cg16482183 chr6:26056742 HIST1H1C 0.52 7.48 0.38 6.66e-13 Height; CRC cis rs10464366 0.957 rs12667577 chr7:39095133 T/G cg18850127 chr7:39170497 POU6F2 0.5 6.43 0.33 4.42e-10 IgG glycosylation; CRC cis rs3018066 0.666 rs12508552 chr4:107030624 G/A cg01869342 chr4:106983673 TBCK 0.46 6.01 0.31 4.84e-9 Cancer; CRC cis rs2115630 1.000 rs4633690 chr15:85361960 C/T cg11189052 chr15:85197271 WDR73 -0.55 -8.99 -0.44 2e-17 P wave terminal force; CRC cis rs1215050 0.874 rs17545594 chr4:98652689 A/G cg05340658 chr4:99064831 C4orf37 -0.44 -6.35 -0.33 7.08e-10 Waist-to-hip ratio adjusted for body mass index; CRC cis rs1552244 0.882 rs3732966 chr3:10015740 C/T cg08888203 chr3:10149979 C3orf24 0.62 8.23 0.41 4.29e-15 Alzheimer's disease; CRC cis rs17270561 0.666 rs4712971 chr6:25771900 T/C cg16482183 chr6:26056742 HIST1H1C 0.75 9.16 0.45 5.85e-18 Iron status biomarkers; CRC cis rs7216064 1.000 rs34872586 chr17:65863466 T/C cg12091567 chr17:66097778 LOC651250 -0.68 -7.87 -0.4 5.31e-14 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CRC trans rs55675132 0.548 rs75634202 chr1:115375464 C/G cg25493687 chr8:27288214 PTK2B 0.5 6.06 0.32 3.77e-9 Schizophrenia; CRC cis rs853679 1.000 rs1419183 chr6:28242794 A/C cg06470822 chr6:28175283 NA 0.67 6.62 0.34 1.48e-10 Depression; CRC cis rs651907 0.557 rs2288272 chr3:101378476 C/T cg12386194 chr3:101231763 SENP7 0.51 7.4 0.38 1.14e-12 Colorectal cancer; CRC cis rs877282 1.000 rs877282 chr10:771532 G/A cg06581033 chr10:766294 NA -0.5 -5.81 -0.31 1.47e-8 Uric acid levels; CRC cis rs7605827 0.930 rs2111456 chr2:15560118 A/G cg19274914 chr2:15703543 NA 0.39 5.86 0.31 1.13e-8 Educational attainment (years of education); CRC trans rs7615952 0.576 rs2276726 chr3:125826287 C/G cg07211511 chr3:129823064 LOC729375 -0.62 -8.69 -0.43 1.68e-16 Blood pressure (smoking interaction); CRC cis rs11098699 0.821 rs12500715 chr4:124230078 T/C cg09941581 chr4:124220074 SPATA5 0.4 5.94 0.31 7.44e-9 Mosquito bite size; CRC cis rs10256972 0.567 rs7782651 chr7:1159895 T/G cg07308232 chr7:1071921 C7orf50 -0.46 -6.05 -0.32 3.91e-9 Longevity;Endometriosis; CRC trans rs10983614 1.000 rs7867776 chr9:120072627 A/G cg19296258 chr17:78878799 RPTOR 0.47 6.33 0.33 8e-10 Survival in pancreatic cancer; CRC cis rs425277 0.606 rs377283 chr1:2075570 T/C cg24578937 chr1:2090814 PRKCZ 0.42 7.65 0.39 2.27e-13 Height; CRC cis rs6580649 0.843 rs3803184 chr12:48398002 G/C cg05342945 chr12:48394962 COL2A1 -0.47 -6.59 -0.34 1.76e-10 Lung cancer; CRC cis rs1862618 0.713 rs832550 chr5:56182589 C/T cg22800045 chr5:56110881 MAP3K1 0.62 6.64 0.34 1.29e-10 Initial pursuit acceleration; CRC cis rs9916302 0.706 rs584377 chr17:37460128 G/A cg00129232 chr17:37814104 STARD3 0.57 7.22 0.37 3.66e-12 Glomerular filtration rate (creatinine); CRC cis rs9896052 0.625 rs11656558 chr17:73440437 T/C cg21038819 chr17:73507788 CASKIN2 0.6 5.61 0.3 4.4e-8 Sight-threatening diabetic retinopathy in type 2 diabetes; CRC cis rs10189230 0.967 rs10498113 chr2:222352629 C/T cg14652038 chr2:222343519 EPHA4 0.51 9.94 0.48 1.54e-20 Urate levels in lean individuals; CRC cis rs1448094 0.845 rs17354637 chr12:86347752 A/G cg00310523 chr12:86230176 RASSF9 0.44 7.53 0.38 5.05e-13 Major depressive disorder; CRC cis rs6570726 0.577 rs441982 chr6:145842848 A/G cg05347473 chr6:146136440 FBXO30 0.48 7.09 0.36 8.08e-12 Lobe attachment (rater-scored or self-reported); CRC cis rs4731207 0.537 rs6466974 chr7:124609510 A/G cg23710748 chr7:124431027 NA -0.39 -6.16 -0.32 2.1e-9 Cutaneous malignant melanoma; CRC trans rs1455244 0.700 rs7229302 chr18:11508904 G/T cg01221484 chr19:58920079 ZNF584 0.4 6.26 0.33 1.18e-9 Schizophrenia; CRC cis rs921968 0.540 rs646295 chr2:219408558 A/C cg02176678 chr2:219576539 TTLL4 0.49 8.13 0.41 8.93e-15 Mean corpuscular hemoglobin concentration; CRC cis rs1949733 1.000 rs1916326 chr4:8500023 G/A cg13073564 chr4:8508604 NA 0.49 7.34 0.38 1.66e-12 Response to antineoplastic agents; CRC cis rs17384381 1.000 rs12758768 chr1:85835206 C/T cg16011679 chr1:85725395 C1orf52 0.65 6.75 0.35 6.76e-11 Lobe attachment (rater-scored or self-reported); CRC cis rs2404602 0.618 rs12442266 chr15:76567142 T/C cg26408565 chr15:76604113 ETFA -0.37 -5.8 -0.3 1.53e-8 Blood metabolite levels; CRC cis rs9527 0.615 rs17725614 chr10:104685493 G/C cg15744005 chr10:104629667 AS3MT -0.31 -6.15 -0.32 2.29e-9 Arsenic metabolism; CRC cis rs787274 0.543 rs4979177 chr9:115644266 G/A cg13803584 chr9:115635662 SNX30 -0.6 -6.2 -0.32 1.72e-9 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs13178541 0.551 rs4315919 chr5:135108794 G/A cg07557560 chr5:134914642 CXCL14 -0.35 -6.09 -0.32 3.09e-9 IgG glycosylation; CRC trans rs12599106 0.770 rs12445057 chr16:34970274 C/G cg11235426 chr6:292522 DUSP22 -0.66 -9.52 -0.46 3.93e-19 Menopause (age at onset); CRC cis rs6788895 1.000 rs73010967 chr3:150498056 T/C cg09723797 chr3:150481914 SIAH2 0.87 5.61 0.3 4.26e-8 Breast cancer; CRC cis rs262150 0.851 rs2527224 chr7:158769198 G/A cg07130601 chr7:158766826 NA 0.4 5.73 0.3 2.23e-8 Facial morphology (factor 20); CRC cis rs7937682 0.883 rs1784776 chr11:111472392 C/T cg19812747 chr11:111475976 SIK2 -0.58 -9.91 -0.48 2e-20 Primary sclerosing cholangitis; CRC cis rs10170846 0.861 rs6740452 chr2:223518452 C/T cg25565276 chr2:223520875 FARSB 0.47 6.23 0.32 1.45e-9 Schizophrenia (inflammation and infection response interaction); CRC cis rs4713118 0.911 rs9461406 chr6:27719764 C/T cg12273811 chr6:28175739 NA -0.53 -6.68 -0.35 1.03e-10 Parkinson's disease; CRC cis rs2153535 0.580 rs9379216 chr6:8481235 G/A cg21535247 chr6:8435926 SLC35B3 0.5 7.51 0.38 5.54e-13 Motion sickness; CRC cis rs6088590 1.000 rs6088607 chr20:33378733 C/T cg24642439 chr20:33292090 TP53INP2 0.59 10.58 0.5 1.07e-22 Coronary artery disease; CRC cis rs10540 0.908 rs35608427 chr11:498976 T/C cg19913688 chr11:428466 ANO9 -0.68 -7.01 -0.36 1.33e-11 Body mass index; CRC cis rs765787 0.530 rs7167731 chr15:45510900 T/C cg24006582 chr15:45444508 DUOX1 0.53 7.71 0.39 1.49e-13 Uric acid levels; CRC cis rs9649213 0.593 rs3823740 chr7:97957104 T/G cg00277769 chr7:97922759 BAIAP2L1 -0.61 -10.65 -0.51 5.74e-23 Prostate cancer (SNP x SNP interaction); CRC cis rs7119 0.651 rs34607443 chr15:77847892 C/T cg10437265 chr15:77819839 NA 0.59 9.97 0.48 1.23e-20 Type 2 diabetes; CRC cis rs17767294 0.612 rs12332927 chr6:27955115 T/C cg15845792 chr6:28175446 NA 0.7 7.57 0.39 3.75e-13 Parkinson's disease; CRC cis rs2549003 1.000 rs17848418 chr5:131821188 C/T cg21138405 chr5:131827807 IRF1 0.57 11.38 0.53 1.59e-25 Asthma (sex interaction); CRC cis rs6694672 1.000 rs1627765 chr1:197033043 C/T cg13682187 chr1:196946512 CFHR5 0.48 7.56 0.38 4.1e-13 Asthma; CRC cis rs9914988 0.943 rs9891925 chr17:27104540 A/T cg12682573 chr17:27188876 MIR451;MIR144 0.58 7.99 0.4 2.37e-14 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC trans rs873549 0.877 rs7550876 chr1:222280229 G/T cg13387374 chr1:19411106 UBR4 0.44 6.0 0.31 5.11e-9 Keloid; CRC cis rs727505 0.819 rs4142718 chr7:124731688 T/A cg23710748 chr7:124431027 NA -0.72 -12.33 -0.56 5.7e-29 Lewy body disease; CRC cis rs8044995 0.563 rs3785113 chr16:68369213 T/C cg09835421 chr16:68378352 PRMT7 -0.76 -8.0 -0.4 2.11e-14 Schizophrenia; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg07639959 chr1:242011162 EXO1 0.45 6.51 0.34 2.88e-10 Intelligence (multi-trait analysis); CRC cis rs7552404 0.690 rs2029681 chr1:76333846 G/A cg03433033 chr1:76189801 ACADM -0.65 -8.48 -0.42 7.52e-16 Blood metabolite levels;Acylcarnitine levels; CRC cis rs1865760 1.000 rs9348698 chr6:25929689 T/A cg16482183 chr6:26056742 HIST1H1C 0.53 7.56 0.38 3.93e-13 Height; CRC cis rs11148252 0.875 rs9568728 chr13:52946593 C/T cg00495681 chr13:53174319 NA 0.54 8.26 0.41 3.61e-15 Lewy body disease; CRC cis rs2806561 0.765 rs1997866 chr1:23512524 A/G cg12483005 chr1:23474871 LUZP1 0.5 7.37 0.38 1.36e-12 Height; CRC cis rs79976124 0.837 rs10455591 chr6:66650584 A/G cg07460842 chr6:66804631 NA 0.75 9.38 0.46 1.07e-18 Type 2 diabetes; CRC cis rs2050392 0.590 rs685319 chr10:30719331 G/A cg18806716 chr10:30721971 MAP3K8 -0.7 -10.18 -0.49 2.43e-21 Inflammatory bowel disease; CRC trans rs916888 0.773 rs538628 chr17:44787313 G/C cg10053473 chr17:62856997 LRRC37A3 -0.79 -8.5 -0.42 6.76e-16 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs4561483 0.831 rs33621 chr16:12008513 G/A cg08843971 chr16:11963173 GSPT1 -0.62 -8.96 -0.44 2.48e-17 Testicular germ cell tumor; CRC cis rs7044106 0.762 rs7044226 chr9:123466328 G/C cg14255062 chr9:123606675 PSMD5;LOC253039 0.48 7.09 0.36 8.41e-12 Hip circumference adjusted for BMI; CRC cis rs17253792 0.822 rs10135426 chr14:56054644 A/G cg01858014 chr14:56050164 KTN1 -0.88 -7.83 -0.4 6.57e-14 Putamen volume; CRC cis rs12523822 0.913 rs9479916 chr6:154960939 G/A cg20019720 chr6:154832845 CNKSR3 0.26 5.66 0.3 3.37e-8 Diabetic kidney disease; CRC cis rs274567 0.501 rs581968 chr5:131710202 G/A cg18301423 chr5:131593218 PDLIM4 -0.38 -6.41 -0.33 5.02e-10 Blood metabolite levels; CRC cis rs10504229 0.775 rs72650869 chr8:58157923 T/A cg20607798 chr8:58055168 NA 0.46 5.69 0.3 2.79e-8 Developmental language disorder (linguistic errors); CRC cis rs2742417 1.000 rs2742422 chr3:45732820 G/A cg04837898 chr3:45731254 SACM1L -0.34 -5.69 -0.3 2.77e-8 Response to anti-depressant treatment in major depressive disorder; CRC cis rs11758351 0.660 rs11755943 chr6:26211368 A/G cg01420254 chr6:26195488 NA 0.75 8.47 0.42 8.46e-16 Gout;Renal underexcretion gout; CRC cis rs72945132 0.882 rs7943840 chr11:70228615 C/A cg14191688 chr11:70257035 CTTN 0.4 5.65 0.3 3.55e-8 Coronary artery disease; CRC cis rs10504229 1.000 rs57624567 chr8:58176995 T/C cg24829409 chr8:58192753 C8orf71 -0.68 -11.34 -0.53 2.27e-25 Developmental language disorder (linguistic errors); CRC trans rs11800820 0.521 rs3120699 chr1:246705509 A/G cg26885821 chr6:124125002 NKAIN2 -0.38 -6.05 -0.32 3.96e-9 Obesity-related traits; CRC cis rs1448094 0.556 rs4897831 chr12:86168248 C/T cg00310523 chr12:86230176 RASSF9 0.4 6.52 0.34 2.7e-10 Major depressive disorder; CRC cis rs10193935 0.901 rs222468 chr2:42642531 C/T cg27598129 chr2:42591480 NA -0.61 -7.47 -0.38 7.48e-13 Colonoscopy-negative controls vs population controls; CRC cis rs7613875 0.543 rs34034116 chr3:49959156 C/A cg24110177 chr3:50126178 RBM5 -0.55 -8.11 -0.41 1.02e-14 Body mass index; CRC cis rs9362426 0.672 rs12663865 chr6:88103149 G/A cg08069147 chr6:88032118 GJB7;C6orf162 0.49 6.3 0.33 9.41e-10 Depressive episodes in bipolar disorder; CRC trans rs634534 0.561 rs613924 chr11:65769295 C/T cg17712092 chr4:129076599 LARP1B 0.68 11.33 0.53 2.39e-25 Sum eosinophil basophil counts;Eosinophil counts; CRC cis rs12042938 0.507 rs1765778 chr1:231732356 G/A cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.61 -9.25 -0.45 2.98e-18 Neuranatomic and neurocognitive phenotypes; CRC cis rs754466 0.580 rs12356063 chr10:79558131 G/C cg26805224 chr10:79626177 DLG5 -0.49 -7.31 -0.37 2.09e-12 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs1728785 0.892 rs1617749 chr16:68580890 A/G cg02972257 chr16:68554789 NA -0.62 -7.27 -0.37 2.57e-12 Ulcerative colitis; CRC cis rs7107174 0.892 rs10431155 chr11:78121978 T/C cg02023728 chr11:77925099 USP35 0.44 6.86 0.35 3.5e-11 Testicular germ cell tumor; CRC cis rs7120118 0.517 rs56177220 chr11:47328377 C/T cg25783544 chr11:47291846 MADD 0.62 5.77 0.3 1.81e-8 HDL cholesterol; CRC trans rs9858542 1.000 rs1131095 chr3:49714225 T/C cg21665057 chr3:196295764 WDR53;FBXO45 -0.66 -8.59 -0.43 3.49e-16 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs9768139 0.935 rs7800718 chr7:158121878 G/A cg25566285 chr7:158114605 PTPRN2 -0.58 -9.57 -0.47 2.73e-19 Calcium levels; CRC cis rs875971 0.545 rs221986 chr7:65570310 T/C cg02869306 chr7:64672164 INTS4L1 0.44 6.36 0.33 6.94e-10 Aortic root size; CRC trans rs1814175 0.717 rs11040450 chr11:49650638 G/A cg11707556 chr5:10655725 ANKRD33B -0.42 -7.73 -0.39 1.35e-13 Height; CRC cis rs2243480 1.000 rs313803 chr7:65514731 G/A cg18252515 chr7:66147081 NA -1.19 -13.16 -0.59 4.5e-32 Diabetic kidney disease; CRC cis rs6662572 0.737 rs10789476 chr1:46305362 G/A cg08644498 chr1:46502608 NA -0.44 -6.82 -0.35 4.37e-11 Blood protein levels; CRC cis rs1005277 0.522 rs1208681 chr10:38092975 C/T cg25517755 chr10:38738941 LOC399744 -0.45 -6.56 -0.34 2.14e-10 Extrinsic epigenetic age acceleration; CRC cis rs2204008 0.729 rs114133083 chr12:38182923 G/C cg13010199 chr12:38710504 ALG10B -0.42 -6.09 -0.32 3.23e-9 Bladder cancer; CRC cis rs9522267 0.535 rs2039916 chr13:112238863 A/C cg14352298 chr13:112236639 NA 0.27 6.11 0.32 2.87e-9 Hepatitis; CRC cis rs5750830 0.649 rs2413590 chr22:39790191 G/C cg05872129 chr22:39784769 NA -0.58 -10.28 -0.49 1.07e-21 Intelligence (multi-trait analysis); CRC cis rs4423214 0.921 rs12807827 chr11:71203790 A/C cg05163923 chr11:71159392 DHCR7 0.64 8.93 0.44 3.1e-17 Vitamin D levels; CRC cis rs3008870 0.583 rs2815369 chr1:67500894 T/C cg11518657 chr1:67396239 MIER1 0.57 6.17 0.32 1.98e-9 Lymphocyte percentage of white cells; CRC cis rs9747347 1 rs9747347 chr17:79606820 T/C cg21028142 chr17:79581711 NPLOC4 0.3 5.68 0.3 2.89e-8 Myopia; CRC cis rs1223397 0.651 rs2458314 chr6:13309224 C/T cg07912922 chr6:13274314 PHACTR1 0.43 6.94 0.36 2.05e-11 Blood pressure; CRC cis rs908922 0.676 rs1538083 chr1:152517116 A/G cg09873164 chr1:152488093 CRCT1 0.37 6.17 0.32 1.95e-9 Hair morphology; CRC cis rs501120 1.000 rs579058 chr10:44755104 A/G cg09554077 chr10:44749378 NA 0.89 13.32 0.59 1.14e-32 Coronary artery disease;Coronary heart disease; CRC cis rs3858526 0.628 rs4237762 chr11:5956626 A/C cg25319279 chr11:5960081 NA -0.34 -5.68 -0.3 3.02e-8 DNA methylation (variation); CRC cis rs853679 0.517 rs9380050 chr6:28048538 A/G cg21251018 chr6:28226885 NKAPL 0.47 6.16 0.32 2.07e-9 Depression; CRC cis rs4400599 0.618 rs2220390 chr1:154233016 C/T cg26808167 chr1:154192205 UBAP2L;C1orf43 -0.38 -6.21 -0.32 1.64e-9 Platelet distribution width; CRC trans rs875971 0.545 rs11767262 chr7:65767224 T/A cg02869306 chr7:64672164 INTS4L1 -0.44 -6.45 -0.34 4.03e-10 Aortic root size; CRC cis rs1639906 0.895 rs62443039 chr7:2209354 C/T cg19897017 chr7:2163380 MAD1L1 -0.6 -8.81 -0.44 7.45e-17 Colonoscopy-negative controls vs population controls; CRC trans rs1161463 0.834 rs1161457 chr13:29434854 G/A cg16311697 chr3:124249497 KALRN -0.45 -6.15 -0.32 2.25e-9 Attention deficit hyperactivity disorder symptoms (maternal expressed emotions interaction); CRC cis rs7666738 0.830 rs13133355 chr4:98919415 A/G cg17366294 chr4:99064904 C4orf37 0.44 7.34 0.37 1.73e-12 Colonoscopy-negative controls vs population controls; CRC trans rs1814175 0.565 rs4881721 chr11:49761851 G/A cg11707556 chr5:10655725 ANKRD33B -0.38 -7.19 -0.37 4.27e-12 Height; CRC cis rs2836974 0.605 rs2836988 chr21:40707975 A/G cg06238570 chr21:40685208 BRWD1 -0.79 -12.13 -0.56 3.16e-28 Cognitive function; CRC trans rs2727020 0.587 rs1164658 chr11:49298551 C/A cg03929089 chr4:120376271 NA 0.82 14.1 0.61 1.17e-35 Coronary artery disease; CRC cis rs12130219 0.500 rs1552991 chr1:152165878 C/T cg23107878 chr1:152161397 NA 0.42 6.14 0.32 2.38e-9 Inflammatory skin disease; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg18281101 chr1:157015843 ARHGEF11 0.39 6.24 0.33 1.36e-9 Liver disease severity in Alagille syndrome; CRC cis rs8031584 0.678 rs798125 chr15:31116800 C/T cg08704250 chr15:31115839 NA 0.53 9.39 0.46 1.01e-18 Huntington's disease progression; CRC cis rs62097350 0.877 rs11659895 chr18:13301705 A/G cg23768505 chr18:13262434 C18orf1 0.59 5.64 0.3 3.69e-8 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; CRC cis rs853679 0.517 rs4713150 chr6:28136212 G/A cg02683197 chr6:28174875 NA 0.87 10.72 0.51 3.38e-23 Depression; CRC cis rs2832191 1.000 rs2832183 chr21:30482150 G/A cg24692254 chr21:30365293 RNF160 -0.64 -11.11 -0.52 1.43e-24 Dental caries; CRC cis rs968567 0.501 rs174553 chr11:61575158 A/G cg06781209 chr11:61594997 FADS2 -0.38 -5.74 -0.3 2.11e-8 Blood metabolite levels;Rheumatoid arthritis;Vitiligo;Glycerophospholipid levels; CRC cis rs9527 0.590 rs10883820 chr10:104764661 A/C cg04362960 chr10:104952993 NT5C2 -0.59 -8.41 -0.42 1.29e-15 Arsenic metabolism; CRC cis rs875971 0.545 rs1547529 chr7:65723846 T/C cg18876405 chr7:65276391 NA 0.45 6.19 0.32 1.77e-9 Aortic root size; CRC cis rs11758351 1.000 rs80095925 chr6:26184942 C/T cg22723502 chr6:26240528 HIST1H4F -0.44 -6.5 -0.34 2.92e-10 Gout;Renal underexcretion gout; CRC cis rs727505 0.551 rs2293346 chr7:124783849 C/T cg23710748 chr7:124431027 NA -0.55 -9.11 -0.45 8.47e-18 Lewy body disease; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg07522440 chr7:143317300 FAM115C 0.4 6.34 0.33 7.67e-10 Liver disease severity in Alagille syndrome; CRC cis rs9325144 0.600 rs10785621 chr12:38744912 C/T cg26384229 chr12:38710491 ALG10B 0.51 7.71 0.39 1.5e-13 Morning vs. evening chronotype; CRC cis rs9811920 0.638 rs796977 chr3:99549723 T/A cg07805332 chr3:99536008 MIR548G;C3orf26 0.51 7.68 0.39 1.83e-13 Axial length; CRC cis rs4689388 0.926 rs5018648 chr4:6292818 C/G cg14416269 chr4:6271139 WFS1 -0.4 -6.61 -0.34 1.53e-10 Type 2 diabetes and other traits;Type 2 diabetes; CRC trans rs8123881 0.733 rs7268466 chr20:15810676 C/T cg17803054 chr19:40927068 NA 0.54 6.21 0.32 1.59e-9 Body mass index; CRC cis rs2180341 1.000 rs13218061 chr6:127653758 G/A cg27446573 chr6:127587934 RNF146 0.99 14.58 0.63 1.75e-37 Breast cancer; CRC cis rs1552244 0.882 rs6796419 chr3:10040812 G/A cg18598329 chr3:10140678 FANCD2;C3orf24 -0.83 -11.7 -0.54 1.12e-26 Alzheimer's disease; CRC cis rs4757319 0.515 rs10832403 chr11:15334129 A/G cg03245590 chr11:15329459 NA -0.53 -9.43 -0.46 7.68e-19 Breast cancer; CRC cis rs519973 0.775 rs6768827 chr3:187639162 A/T cg10168494 chr3:187635183 NA 0.5 8.26 0.41 3.57e-15 Allergic disease (asthma, hay fever or eczema); CRC cis rs11098499 0.774 rs73842616 chr4:120290683 G/A cg09307838 chr4:120376055 NA 0.68 10.53 0.5 1.51e-22 Corneal astigmatism; CRC cis rs10512697 0.655 rs62337684 chr5:3491889 G/C cg19473799 chr5:3511975 NA -0.83 -6.35 -0.33 7.32e-10 Immune response to smallpox vaccine (IL-6); CRC trans rs11098499 0.954 rs10005644 chr4:120298477 T/C cg25214090 chr10:38739885 LOC399744 0.62 9.74 0.47 7.35e-20 Corneal astigmatism; CRC cis rs67517081 1 rs67517081 chr16:30987380 GT/G cg00531865 chr16:30841666 NA 0.42 5.73 0.3 2.32e-8 Mean corpuscular hemoglobin; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg07555182 chr11:82782896 RAB30 0.47 6.53 0.34 2.51e-10 Response to antipsychotic treatment; CRC cis rs938554 0.692 rs6449213 chr4:9994215 A/G cg11266682 chr4:10021025 SLC2A9 -0.4 -6.01 -0.31 4.89e-9 Blood metabolite levels; CRC cis rs67478160 0.619 rs8018062 chr14:104281954 C/T cg01849466 chr14:104193079 ZFYVE21 -0.47 -8.33 -0.42 2.23e-15 Schizophrenia; CRC cis rs6582630 0.638 rs35864536 chr12:38472255 T/A cg26384229 chr12:38710491 ALG10B -0.54 -7.75 -0.39 1.12e-13 Drug-induced liver injury (flucloxacillin); CRC cis rs753778 0.667 rs6578153 chr8:142209543 C/T cg18755752 chr8:142205143 DENND3 -0.65 -11.18 -0.52 8.11e-25 Reticulocyte fraction of red cells;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; CRC cis rs1564271 0.528 rs1980756 chr10:26979371 G/C cg24343755 chr10:26987087 PDSS1 -0.52 -6.84 -0.35 3.88e-11 Overall survival in serous epithelial ovarian cancer treated with paclitaxel and cisplatin; CRC cis rs9479482 1.000 rs9478362 chr6:150340526 T/C cg25797454 chr6:150327115 RAET1K 0.37 6.46 0.34 3.71e-10 Alopecia areata; CRC trans rs9650657 0.562 rs10090444 chr8:10745469 C/G cg06636001 chr8:8085503 FLJ10661 0.58 8.58 0.43 3.72e-16 Neuroticism; CRC cis rs644799 0.735 rs10831432 chr11:95516040 C/A cg25622487 chr11:95524042 FAM76B;CEP57 0.8 13.36 0.59 7.79e-33 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs9325144 0.647 rs61930266 chr12:38922048 A/G cg13010199 chr12:38710504 ALG10B -0.4 -5.65 -0.3 3.57e-8 Morning vs. evening chronotype; CRC cis rs1552244 0.554 rs2272120 chr3:10046703 C/T cg13047869 chr3:10149882 C3orf24 0.38 5.93 0.31 7.73e-9 Alzheimer's disease; CRC cis rs1511802 0.501 rs7683132 chr4:187116039 A/G cg24794857 chr4:187113578 CYP4V2 0.42 6.11 0.32 2.75e-9 Blood protein levels; CRC cis rs7523050 0.643 rs17621922 chr1:109404454 C/T cg08274380 chr1:109419600 GPSM2 0.88 7.3 0.37 2.18e-12 Fat distribution (HIV); CRC cis rs10870270 1.000 rs10870270 chr10:133754334 G/A cg17892150 chr10:133769511 PPP2R2D -0.75 -11.52 -0.54 5.1e-26 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; CRC cis rs9733 0.565 rs11804276 chr1:150685761 T/A cg17724175 chr1:150552817 MCL1 0.57 9.12 0.45 7.76e-18 Tonsillectomy; CRC cis rs7264396 0.635 rs6058355 chr20:34491343 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.58 -9.92 -0.48 1.82e-20 Total cholesterol levels; CRC cis rs12971120 0.588 rs12606654 chr18:72126710 C/T cg26446133 chr18:72167187 CNDP2 -0.61 -6.54 -0.34 2.33e-10 Refractive error; CRC cis rs904251 0.504 rs9380677 chr6:37480366 A/G cg01843034 chr6:37503916 NA -0.4 -7.4 -0.38 1.12e-12 Cognitive performance; CRC cis rs1577917 0.655 rs9444351 chr6:86247799 T/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A 0.49 6.94 0.36 2.06e-11 Response to antipsychotic treatment; CRC cis rs9303401 0.659 rs36109237 chr17:56653834 A/G cg10487724 chr17:56770010 TEX14;RAD51C 0.78 9.59 0.47 2.24e-19 Cognitive test performance; CRC cis rs4819052 0.851 rs2838850 chr21:46671445 G/C cg19498844 chr21:46707878 POFUT2;LOC642852 0.73 10.63 0.51 7.1e-23 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs28386778 0.897 rs2727326 chr17:61923016 G/A cg11494091 chr17:61959527 GH2 0.6 10.33 0.49 7.77e-22 Prudent dietary pattern; CRC trans rs9858542 0.953 rs3811699 chr3:49396360 T/C cg21582582 chr3:182698605 DCUN1D1 -0.52 -6.61 -0.34 1.52e-10 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs9847710 0.967 rs2581824 chr3:53022408 A/C cg18404041 chr3:52824283 ITIH1 -0.3 -5.92 -0.31 8.21e-9 Ulcerative colitis; CRC cis rs6748734 0.857 rs10933638 chr2:241794655 G/A cg16358738 chr2:241808595 AGXT -0.4 -6.27 -0.33 1.14e-9 Urinary metabolites; CRC cis rs6500395 0.962 rs9941336 chr16:48652769 G/A cg04672837 chr16:48644449 N4BP1 0.41 5.82 0.31 1.42e-8 Response to tocilizumab in rheumatoid arthritis; CRC trans rs11098499 0.955 rs11931312 chr4:120159023 T/C cg25214090 chr10:38739885 LOC399744 0.52 8.13 0.41 9.02e-15 Corneal astigmatism; CRC cis rs7677751 0.806 rs7681399 chr4:55090886 T/G cg00691999 chr4:55094011 PDGFRA 0.44 6.33 0.33 8.1e-10 Corneal astigmatism; CRC cis rs1552244 0.752 rs9867091 chr3:10043429 T/C cg13047869 chr3:10149882 C3orf24 0.48 6.8 0.35 4.99e-11 Alzheimer's disease; CRC cis rs2976388 0.566 rs6998746 chr8:143802456 A/C cg24634471 chr8:143751801 JRK 0.41 5.7 0.3 2.61e-8 Urinary tract infection frequency; CRC cis rs908922 0.651 rs548252 chr1:152489742 A/G cg09873164 chr1:152488093 CRCT1 -0.37 -6.25 -0.33 1.29e-9 Hair morphology; CRC cis rs9847710 0.733 rs2581790 chr3:53101780 A/G cg18099408 chr3:52552593 STAB1 0.4 6.14 0.32 2.37e-9 Ulcerative colitis; CRC cis rs2562152 0.613 rs216599 chr16:109671 A/G cg02949481 chr16:131562 MPG 0.59 6.72 0.35 8.06e-11 Glioblastoma; CRC cis rs1799949 0.860 rs8176279 chr17:41210396 A/C cg19454999 chr17:41278357 BRCA1;NBR2 0.41 6.35 0.33 7.01e-10 Menopause (age at onset); CRC cis rs10193935 0.901 rs2088281 chr2:42672731 A/G cg27598129 chr2:42591480 NA 0.7 7.8 0.4 8.16e-14 Colonoscopy-negative controls vs population controls; CRC cis rs79976124 0.837 rs11751994 chr6:66644028 A/C cg07460842 chr6:66804631 NA 0.75 9.38 0.46 1.07e-18 Type 2 diabetes; CRC cis rs2811415 0.597 rs9814694 chr3:127792615 C/T cg13719885 chr3:127795394 NA -0.39 -5.89 -0.31 9.75e-9 Lung function (FEV1/FVC); CRC cis rs2204008 0.807 rs11182461 chr12:38539288 T/C cg26384229 chr12:38710491 ALG10B 0.71 9.58 0.47 2.43e-19 Bladder cancer; CRC cis rs7618915 0.501 rs11130308 chr3:52639257 G/C cg11645453 chr3:52864694 ITIH4 0.36 6.48 0.34 3.4e-10 Bipolar disorder; CRC cis rs12477438 0.520 rs6542870 chr2:99796638 C/T cg14399236 chr2:99771627 LIPT1;TSGA10 0.81 14.32 0.62 1.66e-36 Chronic sinus infection; CRC cis rs3766606 0.505 rs72633047 chr1:7935440 G/A cg26816564 chr1:7831052 VAMP3 0.84 9.11 0.45 8.28e-18 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; CRC cis rs1707322 1.000 rs10890380 chr1:46449469 A/G cg03146154 chr1:46216737 IPP 0.51 7.04 0.36 1.09e-11 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs713587 0.875 rs6746013 chr2:25143649 C/G cg04586622 chr2:25135609 ADCY3 -0.48 -8.49 -0.42 7.33e-16 Body mass index in non-asthmatics; CRC cis rs853679 0.769 rs7752448 chr6:28301099 A/G cg20933634 chr6:27740509 NA 0.59 5.72 0.3 2.43e-8 Depression; CRC trans rs12310956 0.532 rs1352209 chr12:33983408 G/A cg26384229 chr12:38710491 ALG10B 0.47 6.28 0.33 1.06e-9 Morning vs. evening chronotype; CRC cis rs734999 0.550 rs2985855 chr1:2531372 A/C cg20673091 chr1:2541236 MMEL1 -0.36 -5.78 -0.3 1.76e-8 Ulcerative colitis; CRC cis rs6758955 1.000 rs6758955 chr2:10480637 G/T cg15773312 chr2:10472214 HPCAL1 0.73 9.57 0.47 2.59e-19 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; CRC cis rs995000 0.931 rs11207990 chr1:63041086 T/C cg19896129 chr1:63156450 NA -0.43 -6.7 -0.35 8.85e-11 Triglyceride levels; CRC cis rs4332037 0.624 rs58169303 chr7:1883274 T/C cg21155852 chr7:2048760 MAD1L1 -0.42 -6.07 -0.32 3.61e-9 Bipolar disorder; CRC cis rs910316 1.000 rs12588240 chr14:75612083 C/A cg08847533 chr14:75593920 NEK9 0.94 18.28 0.71 5.31e-52 Height; CRC cis rs9311474 0.607 rs13076398 chr3:52573096 G/A cg18099408 chr3:52552593 STAB1 -0.52 -9.18 -0.45 4.91e-18 Electroencephalogram traits; CRC cis rs11628318 0.715 rs1815262 chr14:103056926 C/T cg23461800 chr14:103021989 NA -0.69 -7.65 -0.39 2.28e-13 Platelet count; CRC cis rs1003719 0.715 rs2212742 chr21:38578685 A/G cg10648535 chr21:38446584 PIGP;TTC3 -0.45 -6.28 -0.33 1.06e-9 Eye color traits; CRC cis rs9914988 0.943 rs2874253 chr17:27157863 A/T cg07195577 chr17:27052828 TLCD1 0.41 5.92 0.31 7.89e-9 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs8017423 0.608 rs12589866 chr14:90820977 T/C cg14092571 chr14:90743983 NA 0.39 6.02 0.31 4.76e-9 Mortality in heart failure; CRC cis rs2408955 0.561 rs9971924 chr12:48479832 C/G cg00601486 chr12:48723148 H1FNT -0.34 -6.62 -0.34 1.42e-10 Glycated hemoglobin levels; CRC cis rs9409565 0.793 rs2486632 chr9:97196979 A/G cg04523069 chr9:97136363 HIATL1 0.37 5.69 0.3 2.84e-8 Colorectal cancer (alcohol consumption interaction); CRC cis rs10189230 1.000 rs10189230 chr2:222357961 T/A cg14652038 chr2:222343519 EPHA4 0.54 10.35 0.5 6.27e-22 Urate levels in lean individuals; CRC cis rs3820068 0.581 rs72645888 chr1:15929922 C/A cg13390004 chr1:15929781 NA 0.51 7.2 0.37 4.22e-12 Systolic blood pressure; CRC cis rs12699477 0.545 rs117125814 chr7:1910681 T/G cg02951883 chr7:2050386 MAD1L1 -0.63 -10.57 -0.5 1.12e-22 Testicular germ cell tumor; CRC cis rs11212617 0.967 rs583725 chr11:108165075 A/G cg01991180 chr11:108092276 ATM;NPAT 0.41 5.97 0.31 6.04e-9 Response to metformin in type 2 diabetes (glycemic); CRC cis rs8103278 1.000 rs9807819 chr19:46239598 C/T cg11657440 chr19:46296263 DMWD -0.53 -7.56 -0.38 3.92e-13 Coronary artery disease; CRC cis rs6951245 1.000 rs79422648 chr7:1080241 T/C cg21664854 chr7:1097933 C7orf50;GPR146 0.79 8.94 0.44 2.89e-17 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs1670533 1.000 rs935970 chr4:1045323 C/G cg27284194 chr4:1044797 NA -0.5 -6.07 -0.32 3.62e-9 Recombination rate (females); CRC cis rs1218582 0.741 rs883718 chr1:154846274 C/T cg24250549 chr1:154909240 PMVK 0.61 10.36 0.5 5.88e-22 Prostate cancer; CRC cis rs2279817 0.691 rs7543007 chr1:17990475 A/G cg21791023 chr1:18019539 ARHGEF10L -0.47 -5.65 -0.3 3.39e-8 Neuroticism; CRC cis rs524281 0.773 rs10791863 chr11:66027358 C/T cg14036092 chr11:66035641 RAB1B -0.56 -6.13 -0.32 2.56e-9 Electroencephalogram traits; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg26783523 chr19:18043562 CCDC124 0.46 5.99 0.31 5.42e-9 Thyroid stimulating hormone; CRC cis rs6952808 0.578 rs6949478 chr7:1841342 A/G cg04267008 chr7:1944627 MAD1L1 0.6 7.75 0.39 1.15e-13 Bipolar disorder and schizophrenia; CRC cis rs1448094 0.817 rs10863112 chr12:86330844 C/T cg18827107 chr12:86230957 RASSF9 -0.42 -6.62 -0.34 1.48e-10 Major depressive disorder; CRC cis rs57994353 0.793 rs33982662 chr9:139324737 C/A cg13611204 chr9:139324423 INPP5E -0.43 -6.05 -0.32 3.84e-9 Eosinophil counts;Cutaneous squamous cell carcinoma; CRC cis rs58649573 0.552 rs7049157 chr9:126787006 A/G cg14112217 chr9:126806003 NA 0.4 5.81 0.31 1.44e-8 Post-traumatic stress disorder; CRC cis rs2354432 0.556 rs6593777 chr1:146884013 C/G cg25205988 chr1:146714368 CHD1L 1.11 9.62 0.47 1.8e-19 Mitochondrial DNA levels; CRC cis rs9486719 1.000 rs2205755 chr6:96864704 A/G cg06623918 chr6:96969491 KIAA0776 0.81 9.48 0.46 5.18e-19 Migraine;Coronary artery disease; CRC cis rs4862750 0.872 rs6830828 chr4:187897472 T/G cg10295955 chr4:187884368 NA -1.06 -28.15 -0.84 1.27e-89 Lobe attachment (rater-scored or self-reported); CRC cis rs7917772 0.503 rs56219824 chr10:104302337 C/T cg22532475 chr10:104410764 TRIM8 -0.36 -6.62 -0.34 1.43e-10 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC trans rs11992162 0.636 rs11250182 chr8:11807576 A/T cg08975724 chr8:8085496 FLJ10661 -0.39 -6.06 -0.32 3.72e-9 Monocyte count; CRC cis rs3772130 0.560 rs7649585 chr3:121562300 G/C cg20356878 chr3:121714668 ILDR1 0.37 6.08 0.32 3.24e-9 Cognitive performance; CRC cis rs17767392 1.000 rs34011442 chr14:71779083 G/A cg13720639 chr14:72061746 SIPA1L1 -0.54 -6.9 -0.36 2.71e-11 Mitral valve prolapse; CRC cis rs6504950 0.720 rs9913784 chr17:52989071 A/T cg26251398 chr17:52985966 TOM1L1 0.43 6.53 0.34 2.5e-10 Breast cancer; CRC cis rs9322193 0.886 rs4039600 chr6:149897455 A/G cg00933542 chr6:150070202 PCMT1 0.28 5.68 0.3 2.96e-8 Lung cancer; CRC cis rs3785574 0.886 rs62077504 chr17:61837734 A/G cg22520471 chr17:61851767 DDX42;CCDC47 0.45 6.26 0.33 1.18e-9 Height; CRC cis rs7677751 0.806 rs4864862 chr4:55100489 G/A cg00691999 chr4:55094011 PDGFRA 0.41 5.76 0.3 1.89e-8 Corneal astigmatism; CRC cis rs79839061 0.656 rs28662837 chr4:879776 G/A cg07828340 chr4:882639 GAK 1.1 11.49 0.54 6.24e-26 Intelligence (multi-trait analysis); CRC trans rs4853036 0.629 rs7577864 chr2:70017435 A/G cg14633329 chr9:139640053 LCN6 -0.37 -6.21 -0.32 1.58e-9 Colorectal or endometrial cancer; CRC cis rs10540 1.000 rs12801271 chr11:508720 C/T cg21784768 chr11:537496 LRRC56 -0.7 -6.6 -0.34 1.65e-10 Body mass index; CRC cis rs1799949 1.000 rs1135214 chr17:41292323 T/C cg05368731 chr17:41323189 NBR1 0.65 9.59 0.47 2.27e-19 Menopause (age at onset); CRC cis rs10540 1.000 rs12794284 chr11:477623 C/T cg08200582 chr11:442649 ANO9 -0.7 -7.3 -0.37 2.23e-12 Body mass index; CRC cis rs875971 0.545 rs6970498 chr7:65740895 A/G cg11764359 chr7:65958608 NA 0.45 5.67 0.3 3.06e-8 Aortic root size; CRC trans rs9358372 0.671 rs10946416 chr6:20883616 T/G cg14519598 chr9:36906608 PAX5 -0.45 -6.06 -0.32 3.71e-9 Inflammatory bowel disease;Crohn's disease; CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg18450072 chr4:40058936 LOC344967;N4BP2 0.4 6.24 0.33 1.34e-9 Obesity-related traits; CRC trans rs459571 0.959 rs455381 chr9:136905577 C/A cg15028160 chr19:49622717 PPFIA3;C19orf73 -0.56 -6.9 -0.36 2.69e-11 Platelet distribution width; CRC cis rs6684514 0.961 rs12029695 chr1:156299847 C/T cg16558208 chr1:156270281 VHLL 0.56 8.76 0.43 1.06e-16 Mean corpuscular hemoglobin concentration;Glycated hemoglobin levels; CRC cis rs3768617 0.510 rs3768622 chr1:183090011 G/A ch.1.3577855R chr1:183094577 LAMC1 0.84 14.2 0.62 5.08e-36 Fuchs's corneal dystrophy; CRC cis rs6951245 0.580 rs78894484 chr7:1138721 T/G cg22907277 chr7:1156413 C7orf50 0.8 10.17 0.49 2.64e-21 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs4789294 0.806 rs898085 chr17:74393681 A/G cg06840243 chr17:74442338 UBE2O 0.41 6.05 0.32 3.88e-9 Lymphocyte percentage of white cells; CRC cis rs9649213 0.593 rs3801255 chr7:98000929 C/T cg00277769 chr7:97922759 BAIAP2L1 -0.6 -10.46 -0.5 2.68e-22 Prostate cancer (SNP x SNP interaction); CRC cis rs7662987 0.517 rs3018047 chr4:100014510 C/T cg13256891 chr4:100009986 ADH5 -0.64 -8.48 -0.42 7.6e-16 Smoking initiation; CRC cis rs1218582 0.772 rs12095061 chr1:154912968 A/T cg16680214 chr1:154839983 KCNN3 -0.45 -8.77 -0.44 9.93e-17 Prostate cancer; CRC cis rs6500395 1.000 rs11641458 chr16:48670845 C/T cg04672837 chr16:48644449 N4BP1 0.45 6.73 0.35 7.64e-11 Response to tocilizumab in rheumatoid arthritis; CRC cis rs1448094 0.511 rs1993807 chr12:86146833 A/G cg18827107 chr12:86230957 RASSF9 0.39 5.96 0.31 6.52e-9 Major depressive disorder; CRC cis rs10504229 1.000 rs66495524 chr8:58187365 C/T cg05313129 chr8:58192883 C8orf71 -0.47 -6.99 -0.36 1.49e-11 Developmental language disorder (linguistic errors); CRC cis rs9910055 0.529 rs2523161 chr17:42179405 C/T cg09913183 chr17:42254507 C17orf65;ASB16 -0.5 -6.88 -0.35 2.98e-11 Total body bone mineral density; CRC cis rs9611565 0.765 rs132921 chr22:41812044 G/A cg06634786 chr22:41940651 POLR3H 0.56 6.54 0.34 2.38e-10 Vitiligo; CRC trans rs2303319 0.504 rs56965753 chr2:162597251 A/G cg22902534 chr3:183892754 AP2M1 -0.7 -6.1 -0.32 2.96e-9 Cognitive function; CRC cis rs7487075 0.786 rs7966288 chr12:46674970 C/T cg22049899 chr12:47219821 SLC38A4 0.32 5.77 0.3 1.84e-8 Itch intensity from mosquito bite; CRC trans rs11098499 0.569 rs10023641 chr4:120258410 C/G cg25214090 chr10:38739885 LOC399744 0.55 8.98 0.44 2.06e-17 Corneal astigmatism; CRC cis rs6952808 0.689 rs12668156 chr7:2019875 G/A cg04267008 chr7:1944627 MAD1L1 -0.78 -10.97 -0.52 4.45e-24 Bipolar disorder and schizophrenia; CRC cis rs7208859 0.673 rs9914271 chr17:29232625 G/A cg13385521 chr17:29058706 SUZ12P 0.65 7.62 0.39 2.68e-13 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs9393692 0.905 rs1124999 chr6:26287043 G/T cg00631329 chr6:26305371 NA -0.69 -13.58 -0.6 1.15e-33 Educational attainment; CRC cis rs780096 0.526 rs780117 chr2:27698343 C/G cg02592271 chr2:27665507 KRTCAP3 -0.28 -6.58 -0.34 1.83e-10 Total body bone mineral density; CRC cis rs6499255 0.951 rs16959025 chr16:69695589 G/T cg15192750 chr16:69999425 NA -0.67 -8.95 -0.44 2.67e-17 IgE levels; CRC cis rs13394619 1.000 rs2884374 chr2:11731846 C/T cg07314298 chr2:11723111 GREB1 0.49 8.22 0.41 4.76e-15 Endometriosis; CRC cis rs561341 1.000 rs537166 chr17:30326827 C/T cg12193833 chr17:30244370 NA -0.64 -8.32 -0.42 2.33e-15 Hip circumference adjusted for BMI; CRC cis rs9354308 0.899 rs2814099 chr6:66555130 A/G cg07460842 chr6:66804631 NA 0.47 5.83 0.31 1.29e-8 Metabolite levels; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg06766450 chr1:16766999 NECAP2 0.5 6.54 0.34 2.38e-10 Thyroid stimulating hormone; CRC trans rs61931739 0.534 rs35056575 chr12:34142914 A/T cg26384229 chr12:38710491 ALG10B 0.54 6.92 0.36 2.31e-11 Morning vs. evening chronotype; CRC cis rs898097 0.812 rs8065641 chr17:80820259 A/G cg15664640 chr17:80829946 TBCD -0.69 -11.73 -0.54 8.82e-27 Breast cancer; CRC cis rs6502050 0.835 rs11077971 chr17:80090629 A/G cg19223190 chr17:80058835 NA 0.39 6.14 0.32 2.39e-9 Life satisfaction; CRC trans rs2303319 0.504 rs62187657 chr2:162488091 G/A cg12500891 chr11:57225987 NA -0.69 -6.05 -0.32 4.05e-9 Cognitive function; CRC trans rs7618501 0.574 rs6765484 chr3:50041313 C/T cg21665057 chr3:196295764 WDR53;FBXO45 -0.57 -9.2 -0.45 4.18e-18 Intelligence (multi-trait analysis); CRC cis rs2836950 0.520 rs59916147 chr21:40634702 T/G cg11890956 chr21:40555474 PSMG1 -0.7 -10.42 -0.5 3.81e-22 Menarche (age at onset); CRC cis rs13082711 0.911 rs35262121 chr3:27508277 G/A cg02860705 chr3:27208620 NA 0.59 8.23 0.41 4.43e-15 Systolic blood pressure;Diastolic blood pressure;Blood pressure; CRC cis rs7223966 1.000 rs11657120 chr17:61857218 G/A cg05941027 chr17:61774174 LIMD2 0.35 6.3 0.33 9.71e-10 Hip circumference adjusted for BMI;Body mass index; CRC cis rs208520 0.661 rs7740835 chr6:66865548 G/A cg07460842 chr6:66804631 NA -1.07 -14.89 -0.63 1.12e-38 Exhaled nitric oxide output; CRC cis rs4555082 0.834 rs2816623 chr14:105733295 G/A cg06808227 chr14:105710500 BRF1 -0.61 -8.58 -0.43 3.85e-16 Mean platelet volume;Platelet distribution width; CRC cis rs4713118 0.869 rs6922574 chr6:27693003 A/T cg15845792 chr6:28175446 NA 0.62 8.29 0.42 2.97e-15 Parkinson's disease; CRC cis rs2625529 0.529 rs7183055 chr15:72377048 C/T cg16672083 chr15:72433130 SENP8 0.44 6.68 0.35 1.03e-10 Red blood cell count; CRC cis rs11650494 0.901 rs117087923 chr17:47364913 G/A cg08112188 chr17:47440006 ZNF652 1.2 10.77 0.51 2.33e-23 Prostate cancer; CRC cis rs12971120 0.947 rs7241558 chr18:72169267 A/T cg26446133 chr18:72167187 CNDP2 -0.76 -15.24 -0.64 4.77e-40 Refractive error; CRC cis rs1448094 0.512 rs7970081 chr12:86243392 G/T cg25456477 chr12:86230367 RASSF9 0.32 5.67 0.3 3.13e-8 Major depressive disorder; CRC cis rs10883723 0.810 rs10786669 chr10:104256094 C/G cg11453585 chr10:104263688 ACTR1A;SUFU 0.91 17.39 0.69 1.62e-48 Allergic disease (asthma, hay fever or eczema); CRC cis rs853679 0.517 rs9393888 chr6:28059217 G/C cg15786705 chr6:28176104 NA 0.76 9.63 0.47 1.68e-19 Depression; CRC cis rs7607369 0.782 rs514799 chr2:219411203 A/G cg02176678 chr2:219576539 TTLL4 0.54 8.69 0.43 1.78e-16 Red blood cell count;Amyotrophic lateral sclerosis; CRC cis rs9942416 0.650 rs2640646 chr5:74977458 A/T cg19683494 chr5:74908142 NA -0.49 -6.27 -0.33 1.15e-9 Age-related disease endophenotypes; CRC cis rs1008375 0.966 rs4698638 chr4:17632988 G/C cg04450456 chr4:17643702 FAM184B 0.41 6.7 0.35 8.9e-11 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs9522267 0.535 rs9522302 chr13:112236874 C/T cg10483660 chr13:112241077 NA -0.48 -9.1 -0.45 9.18e-18 Hepatitis; CRC trans rs944990 0.595 rs10123378 chr9:96375217 C/T cg01373691 chr16:71917765 ZNF821;ATXN1L 0.45 6.61 0.34 1.51e-10 Body mass index; CRC cis rs853679 0.723 rs1736904 chr6:28219270 G/A cg12273811 chr6:28175739 NA 0.63 7.72 0.39 1.37e-13 Depression; CRC cis rs7914558 1.000 rs10786733 chr10:104794947 G/A cg15744005 chr10:104629667 AS3MT -0.33 -7.1 -0.36 7.64e-12 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs13031619 0.660 rs34855424 chr2:3702780 C/A cg19052272 chr2:3704530 ALLC -0.88 -10.67 -0.51 5.23e-23 Response to inhaled corticosteroid treatment in asthma (change in FEV1); CRC cis rs7615952 0.599 rs2279821 chr3:125734308 G/A cg06494592 chr3:125709126 NA -0.56 -6.52 -0.34 2.66e-10 Blood pressure (smoking interaction); CRC cis rs2072510 0.593 rs2660900 chr12:96405077 T/C cg22491680 chr12:96389547 HAL -0.46 -5.73 -0.3 2.23e-8 Metabolite levels (small molecules and protein measures); CRC cis rs4713118 0.824 rs9366702 chr6:27734470 T/C cg12273811 chr6:28175739 NA 0.51 6.69 0.35 9.56e-11 Parkinson's disease; CRC cis rs8040855 0.542 rs2342122 chr15:85728535 C/G cg04831495 chr15:85060580 GOLGA6L5 0.4 6.09 0.32 3.15e-9 Bulimia nervosa; CRC trans rs3960554 0.808 rs13438599 chr7:75768022 G/A cg19862616 chr7:65841803 NCRNA00174 0.74 8.75 0.43 1.11e-16 Eotaxin levels; CRC cis rs6674176 0.597 rs4660262 chr1:44382524 G/A cg15962314 chr1:44399869 ARTN 0.32 6.28 0.33 1.1e-9 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Cognitive ability; CRC cis rs12701220 0.744 rs10499317 chr7:1012103 C/G cg02733842 chr7:1102375 C7orf50 -0.56 -6.97 -0.36 1.69e-11 Bronchopulmonary dysplasia; CRC cis rs6546324 0.625 rs1430790 chr2:67864912 G/T cg15745817 chr2:67799979 NA 0.51 9.03 0.45 1.52e-17 Endometriosis; CRC cis rs5750830 0.649 rs5757659 chr22:39812409 A/C cg05872129 chr22:39784769 NA -0.58 -9.81 -0.48 4.37e-20 Intelligence (multi-trait analysis); CRC cis rs853679 0.542 rs6934769 chr6:28090931 A/G cg23161317 chr6:28129485 ZNF389 0.53 6.54 0.34 2.37e-10 Depression; CRC cis rs2404602 0.735 rs2048856 chr15:76800083 C/T cg23625390 chr15:77176239 SCAPER -0.74 -11.47 -0.53 7.3e-26 Blood metabolite levels; CRC cis rs2075371 0.932 rs2241333 chr7:133970750 C/T cg20476274 chr7:133979776 SLC35B4 0.77 13.81 0.61 1.57e-34 Mean platelet volume; CRC trans rs12478296 0.892 rs11893879 chr2:243010411 G/A cg06834434 chr14:75079333 LTBP2 0.55 6.88 0.35 3.04e-11 Obesity-related traits; CRC cis rs4713118 0.826 rs2893929 chr6:27738732 A/T cg06470822 chr6:28175283 NA 0.84 9.56 0.47 2.85e-19 Parkinson's disease; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg01297674 chr2:122406765 CLASP1 0.54 6.91 0.36 2.6e-11 Thyroid stimulating hormone; CRC cis rs2073499 1.000 rs57319506 chr3:50285677 T/C cg09545109 chr3:50388910 TUSC4;CYB561D2 0.61 5.73 0.3 2.33e-8 Schizophrenia; CRC cis rs7615952 0.599 rs6766327 chr3:125723677 C/G cg05084668 chr3:125655381 ALG1L -0.47 -6.64 -0.34 1.32e-10 Blood pressure (smoking interaction); CRC cis rs9814567 1.000 rs11928499 chr3:134232350 A/G cg06109529 chr3:134205091 CEP63;ANAPC13 0.84 12.28 0.56 8.32e-29 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs4332037 0.906 rs62442903 chr7:1953416 G/A cg25834613 chr7:1915315 MAD1L1 -0.44 -6.31 -0.33 8.78e-10 Bipolar disorder; CRC cis rs9814567 1.000 rs35718987 chr3:134272783 C/T cg06541857 chr3:134203789 ANAPC13;CEP63 0.39 5.74 0.3 2.15e-8 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs10870270 1.000 rs10159943 chr10:133744744 T/C cg17892150 chr10:133769511 PPP2R2D -0.73 -10.98 -0.52 4.07e-24 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; CRC cis rs1401999 1.000 rs6802849 chr3:183698943 A/C cg01324343 chr3:183735012 ABCC5 0.81 14.74 0.63 4.18e-38 Anterior chamber depth; CRC cis rs7591163 1.000 rs6436741 chr2:228714598 G/A cg08034379 chr2:228736324 WDR69 -0.53 -7.22 -0.37 3.59e-12 Blood pressure; CRC cis rs6460942 1.000 rs77494477 chr7:12315302 A/T cg20607287 chr7:12443886 VWDE -0.64 -6.41 -0.33 5.11e-10 Coronary artery disease; CRC cis rs8180040 0.966 rs11710322 chr3:47331136 C/T cg27129171 chr3:47204927 SETD2 -0.66 -10.07 -0.49 5.83e-21 Colorectal cancer; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg17274771 chr17:7465072 SENP3 0.41 7.2 0.37 4.12e-12 Liver disease severity in Alagille syndrome; CRC cis rs9649213 0.593 rs6944262 chr7:97985415 T/G cg21770322 chr7:97807741 LMTK2 0.52 8.48 0.42 7.59e-16 Prostate cancer (SNP x SNP interaction); CRC cis rs7264396 0.563 rs59064961 chr20:34307950 T/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.49 -6.77 -0.35 6.03e-11 Total cholesterol levels; CRC cis rs7647973 0.506 rs11920251 chr3:49356671 C/T cg20833759 chr3:49053208 WDR6;DALRD3 0.34 5.67 0.3 3.14e-8 Menarche (age at onset); CRC cis rs6459788 0.502 rs9692347 chr7:157232659 C/T cg03453431 chr7:157225567 NA -0.55 -8.45 -0.42 9.79e-16 Epstein-Barr virus copy number in lymphoblastoid cell lines; CRC cis rs7843479 0.562 rs2127206 chr8:21786989 C/T cg17168535 chr8:21777572 XPO7 0.67 11.34 0.53 2.15e-25 Mean corpuscular volume; CRC cis rs8072100 0.512 rs9303533 chr17:45386540 A/G cg08085267 chr17:45401833 C17orf57 -0.74 -12.84 -0.58 6.94e-31 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs7827545 1.000 rs7827545 chr8:135566567 C/T cg07299736 chr8:135490787 ZFAT -0.37 -6.23 -0.32 1.46e-9 Hypertension (SNP x SNP interaction); CRC cis rs12188164 0.686 rs72711365 chr5:416672 G/A cg16322479 chr5:444228 EXOC3;C5orf55 0.4 6.41 0.33 5.03e-10 Cystic fibrosis severity; CRC cis rs10045504 0.502 rs17352898 chr5:38745498 C/T cg15396434 chr5:38725168 NA -0.6 -6.01 -0.31 4.86e-9 Night sleep phenotypes; CRC cis rs73206853 0.841 rs3026479 chr12:110779034 A/G cg12870014 chr12:110450643 ANKRD13A 0.78 6.73 0.35 7.49e-11 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC cis rs56399783 0.901 rs73049362 chr7:2826822 G/A cg19731401 chr7:2775893 GNA12 0.68 7.33 0.37 1.76e-12 Childhood ear infection; CRC trans rs1455244 0.700 rs7229302 chr18:11508904 G/T cg14584865 chr2:128615641 POLR2D 0.38 5.97 0.31 5.99e-9 Schizophrenia; CRC cis rs2242116 0.932 rs4683301 chr3:46931478 A/T cg27129171 chr3:47204927 SETD2 -0.44 -6.32 -0.33 8.71e-10 Birth weight; CRC cis rs7072216 0.727 rs942809 chr10:100168001 G/A cg26618903 chr10:100175079 PYROXD2 -0.51 -8.43 -0.42 1.08e-15 Metabolite levels; CRC cis rs2302190 0.882 rs8073754 chr17:56618030 C/T cg12560992 chr17:57184187 TRIM37 0.51 5.99 0.31 5.48e-9 Vitamin D levels; CRC cis rs6867032 0.695 rs3902820 chr5:2000330 T/A cg26168224 chr5:2018326 NA -0.85 -14.36 -0.62 1.21e-36 Gut microbiome composition (winter); CRC cis rs1572438 0.792 rs17139759 chr6:856754 G/A cg13447295 chr6:887704 NA -0.42 -6.12 -0.32 2.66e-9 Aging; CRC cis rs6088580 0.634 rs4258875 chr20:32924895 C/A cg08999081 chr20:33150536 PIGU -0.63 -11.92 -0.55 1.8e-27 Glomerular filtration rate (creatinine); CRC cis rs11608355 0.545 rs1073779 chr12:109894721 C/T cg05360138 chr12:110035743 NA 0.77 8.7 0.43 1.65e-16 Neuroticism; CRC cis rs1046896 1.000 rs9909940 chr17:80689036 C/T cg17346650 chr17:80929145 B3GNTL1 0.37 6.01 0.31 4.92e-9 Glycated hemoglobin levels; CRC cis rs6502050 0.765 rs55905076 chr17:80105441 G/A cg02741985 chr17:80059408 CCDC57 0.43 7.04 0.36 1.09e-11 Life satisfaction; CRC cis rs2635047 0.713 rs9952628 chr18:44754651 G/A cg19077165 chr18:44547161 KATNAL2 -0.44 -6.4 -0.33 5.41e-10 Educational attainment; CRC cis rs2072499 0.966 rs11587860 chr1:156156951 G/C cg25208724 chr1:156163844 SLC25A44 1.08 24.97 0.81 6.05e-78 Testicular germ cell tumor; CRC cis rs76878669 0.561 rs4244813 chr11:66129488 G/C cg18002602 chr11:66138449 SLC29A2 0.28 6.1 0.32 2.94e-9 Educational attainment (years of education); CRC cis rs9326248 0.954 rs4938349 chr11:117021923 C/T cg11861562 chr11:117069780 TAGLN 0.4 9.0 0.44 1.79e-17 Blood protein levels; CRC trans rs2228479 0.702 rs17233868 chr16:89803629 C/T cg24644049 chr4:85504048 CDS1 0.9 7.39 0.38 1.19e-12 Skin colour saturation; CRC cis rs6952808 0.771 rs10950415 chr7:1914477 A/G cg14004847 chr7:1930337 MAD1L1 -0.46 -6.92 -0.36 2.44e-11 Bipolar disorder and schizophrenia; CRC cis rs10504229 0.679 rs12675340 chr8:58035501 T/A cg02725872 chr8:58115012 NA -0.35 -5.99 -0.31 5.51e-9 Developmental language disorder (linguistic errors); CRC cis rs12497850 0.931 rs7616815 chr3:48779715 C/T cg20833759 chr3:49053208 WDR6;DALRD3 0.5 8.49 0.42 7.31e-16 Parkinson's disease; CRC cis rs9391253 0.571 rs11156429 chr6:105364421 T/G cg02098413 chr6:105308735 HACE1 0.31 5.6 0.3 4.51e-8 Height;Age at voice drop;Puberty onset (breast development); CRC cis rs990171 0.913 rs2075185 chr2:103070988 A/G cg03938978 chr2:103052716 IL18RAP 0.48 6.2 0.32 1.72e-9 Lymphocyte counts; CRC cis rs12190007 0.604 rs7382308 chr6:169732276 A/C cg16388071 chr6:169726476 NA -0.38 -5.72 -0.3 2.45e-8 Obesity-related traits; CRC cis rs875971 1.000 rs4718344 chr7:65874381 C/A cg18912574 chr7:65842487 NCRNA00174 0.36 6.18 0.32 1.88e-9 Aortic root size; CRC cis rs921968 0.565 rs6436070 chr2:219597960 A/G cg02176678 chr2:219576539 TTLL4 -0.39 -6.36 -0.33 6.82e-10 Mean corpuscular hemoglobin concentration; CRC cis rs62103177 0.810 rs62103175 chr18:77622467 C/T cg12964065 chr18:77638022 KCNG2 0.66 6.96 0.36 1.88e-11 Opioid sensitivity; CRC cis rs8072100 0.967 rs4239163 chr17:45755954 C/T cg08085267 chr17:45401833 C17orf57 -0.61 -9.68 -0.47 1.17e-19 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs4481887 0.617 rs28719164 chr1:248543802 T/G cg26353448 chr1:248524236 OR2T4 -0.35 -7.08 -0.36 8.96e-12 Common traits (Other); CRC cis rs55788414 0.932 rs2317122 chr16:81182819 A/G cg06400318 chr16:81190750 PKD1L2 -0.59 -6.78 -0.35 5.73e-11 Left ventricular obstructive tract defect (maternal effect); CRC trans rs3753275 0.564 rs6676113 chr1:8910544 T/C cg25376875 chr2:9459453 ASAP2 0.51 6.04 0.32 4.06e-9 Educational attainment; CRC trans rs9858542 0.953 rs11710037 chr3:49675334 C/G cg21582582 chr3:182698605 DCUN1D1 -0.53 -6.39 -0.33 5.65e-10 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs873946 0.586 rs3793682 chr10:134564563 C/T cg27286337 chr10:134555280 INPP5A 0.82 9.97 0.48 1.25e-20 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CRC cis rs887829 0.570 rs6724485 chr2:234592816 G/A cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.49 -7.61 -0.39 2.98e-13 Metabolic traits;Bilirubin levels;Cholelithiasis-related traits in sickle cell anemia;Metabolite levels;Total bilirubin levels in HIV-1 infection;Serum metabolite levels;Blood metabolite levels; CRC cis rs13082711 0.522 rs653886 chr3:27343549 C/T cg02860705 chr3:27208620 NA 0.46 6.89 0.35 2.92e-11 Systolic blood pressure;Diastolic blood pressure;Blood pressure; CRC cis rs4285028 0.699 rs2689285 chr3:121586486 G/A cg11130432 chr3:121712080 ILDR1 0.52 6.35 0.33 6.99e-10 Multiple sclerosis; CRC cis rs11764590 0.694 rs7797112 chr7:2085165 T/C cg23422044 chr7:1970798 MAD1L1 -0.42 -5.96 -0.31 6.62e-9 Neuroticism; CRC cis rs754466 0.580 rs2289309 chr10:79571108 C/T cg26805224 chr10:79626177 DLG5 -0.49 -7.29 -0.37 2.37e-12 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs35883536 0.528 rs1414414 chr1:101028907 T/C cg06223162 chr1:101003688 GPR88 0.4 7.36 0.38 1.47e-12 Monocyte count; CRC cis rs2742417 0.624 rs2673030 chr3:45757900 T/G cg04837898 chr3:45731254 SACM1L -0.49 -7.9 -0.4 4.31e-14 Response to anti-depressant treatment in major depressive disorder; CRC cis rs6570726 0.935 rs367643 chr6:145859602 A/C cg23711669 chr6:146136114 FBXO30 0.7 12.46 0.57 1.8e-29 Lobe attachment (rater-scored or self-reported); CRC cis rs12530134 0.519 rs3920484 chr6:170746081 A/G cg18217622 chr6:170732253 NA 0.59 5.73 0.3 2.31e-8 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs9894429 0.716 rs7405578 chr17:79588306 C/A cg21028142 chr17:79581711 NPLOC4 0.33 6.98 0.36 1.68e-11 Eye color traits; CRC cis rs9399135 0.967 rs12527707 chr6:135324511 G/A cg22676075 chr6:135203613 NA 0.42 6.51 0.34 2.78e-10 Red blood cell count; CRC cis rs12024301 0.557 rs12029647 chr1:183593968 G/C cg11505048 chr1:183622726 RGL1;APOBEC4 0.76 6.93 0.36 2.16e-11 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs644799 0.932 rs480079 chr11:95643777 A/T cg25622487 chr11:95524042 FAM76B;CEP57 -0.68 -10.35 -0.5 6.27e-22 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs7666738 0.830 rs4502686 chr4:98765117 T/C cg17366294 chr4:99064904 C4orf37 0.42 6.91 0.36 2.59e-11 Colonoscopy-negative controls vs population controls; CRC trans rs7647973 0.710 rs34890793 chr3:49619493 C/T cg21665057 chr3:196295764 WDR53;FBXO45 -0.71 -7.9 -0.4 4.16e-14 Menarche (age at onset); CRC cis rs72781680 0.611 rs2303289 chr2:24342242 C/G cg20701182 chr2:24300061 SF3B14 -0.67 -8.01 -0.4 1.96e-14 Lymphocyte counts; CRC cis rs10789491 1.000 rs7547522 chr1:47179918 C/G cg15501359 chr1:47185051 KIAA0494 0.76 9.15 0.45 6.19e-18 Response to hepatitis C treatment; CRC cis rs7208859 0.725 rs9897673 chr17:29243366 T/C cg13385521 chr17:29058706 SUZ12P 0.53 7.27 0.37 2.64e-12 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs911555 0.755 rs2273702 chr14:103918182 C/G cg24130564 chr14:104152367 KLC1 0.43 5.94 0.31 7.26e-9 Intelligence (multi-trait analysis); CRC cis rs2657888 0.628 rs7314242 chr12:56876372 C/A cg23002907 chr12:56915593 RBMS2 -0.38 -5.89 -0.31 9.4e-9 Adiponectin levels; CRC cis rs7385804 0.796 rs221799 chr7:100288545 G/A cg20848291 chr7:100343083 ZAN 0.49 7.58 0.39 3.51e-13 Iron status biomarkers;Mean corpuscular hemoglobin;Hematocrit;Iron status biomarkers (transferrin saturation);Red blood cell count;Iron status biomarkers (iron levels);Mean corpuscular volume;Hematological parameters; CRC trans rs66573146 0.572 rs67750430 chr4:6957266 T/G cg07817883 chr1:32538562 TMEM39B 1.02 11.31 0.53 2.92e-25 Granulocyte percentage of myeloid white cells; CRC cis rs7737355 0.947 rs6890784 chr5:130939540 T/C cg25547332 chr5:131281432 NA 0.41 5.72 0.3 2.42e-8 Life satisfaction; CRC cis rs11122272 0.735 rs2808591 chr1:231523421 G/A cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.54 -8.14 -0.41 7.99e-15 Hemoglobin concentration; CRC trans rs7615952 0.673 rs9841194 chr3:125635739 C/T cg07211511 chr3:129823064 LOC729375 -1.1 -12.97 -0.58 2.41e-31 Blood pressure (smoking interaction); CRC cis rs6546324 0.625 rs1023693 chr2:67868732 T/C cg15745817 chr2:67799979 NA -0.55 -9.54 -0.47 3.34e-19 Endometriosis; CRC cis rs5750830 0.649 rs7949 chr22:39827553 G/A cg05872129 chr22:39784769 NA -0.62 -12.21 -0.56 1.51e-28 Intelligence (multi-trait analysis); CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg26399773 chr5:74633655 HMGCR -0.38 -6.03 -0.32 4.3e-9 Myopia (pathological); CRC cis rs7618915 0.501 rs767418 chr3:52767427 C/T cg05573699 chr3:52720067 GNL3;PBRM1 -0.47 -6.83 -0.35 3.99e-11 Bipolar disorder; CRC cis rs10504229 0.593 rs77607045 chr8:58010464 T/C cg22535103 chr8:58192502 C8orf71 -0.64 -7.01 -0.36 1.34e-11 Developmental language disorder (linguistic errors); CRC cis rs951366 0.528 rs1172198 chr1:205662718 C/T cg17178900 chr1:205818956 PM20D1 0.6 8.29 0.42 2.84e-15 Menarche (age at onset); CRC cis rs1881797 0.527 rs1852908 chr1:247678260 C/T cg21399703 chr1:247681439 NA 0.49 5.7 0.3 2.61e-8 Acute lymphoblastic leukemia (childhood); CRC cis rs478304 0.651 rs4930313 chr11:65500428 C/T cg27068330 chr11:65405492 SIPA1 -0.63 -9.75 -0.47 6.92e-20 Acne (severe); CRC cis rs11608355 0.545 rs12819658 chr12:109907670 A/T cg05360138 chr12:110035743 NA 0.78 8.75 0.43 1.15e-16 Neuroticism; CRC cis rs7617480 0.610 rs10865954 chr3:49211989 T/C cg06212747 chr3:49208901 KLHDC8B 0.41 6.26 0.33 1.17e-9 Subjective well-being (multi-trait analysis);Menarche (age at onset); CRC trans rs7937682 0.924 rs10891288 chr11:111552053 G/T cg18187862 chr3:45730750 SACM1L -0.46 -6.67 -0.35 1.06e-10 Primary sclerosing cholangitis; CRC cis rs6088590 0.561 rs6087605 chr20:33180624 G/T cg24642439 chr20:33292090 TP53INP2 0.4 6.92 0.36 2.33e-11 Coronary artery disease; CRC cis rs62064224 0.614 rs9900089 chr17:30772577 C/T cg09324608 chr17:30823087 MYO1D 0.35 6.0 0.31 5.14e-9 Schizophrenia; CRC cis rs10883723 0.810 rs7079810 chr10:104243883 C/T cg11453585 chr10:104263688 ACTR1A;SUFU 0.9 16.03 0.66 3.98e-43 Allergic disease (asthma, hay fever or eczema); CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg05910615 chr19:36248877 HSPB6;C19orf55 0.4 6.29 0.33 1.03e-9 Obesity-related traits; CRC cis rs7618915 0.501 rs2159644 chr3:52774530 C/T cg08222913 chr3:52553049 STAB1 -0.33 -6.12 -0.32 2.72e-9 Bipolar disorder; CRC cis rs60843830 1.000 rs62114544 chr2:269679 C/T cg00108164 chr2:264199 ACP1;SH3YL1 0.61 9.64 0.47 1.51e-19 Spherical equivalent (joint analysis main effects and education interaction); CRC cis rs1186222 0.501 rs12534422 chr7:75263792 A/G cg05145297 chr7:75264568 HIP1 -0.67 -12.17 -0.56 2.15e-28 Basophil percentage of granulocytes;White blood cell count (basophil);Basophil percentage of white cells; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg06210147 chr17:40428290 STAT5B 0.46 7.48 0.38 6.86e-13 Liver disease severity in Alagille syndrome; CRC cis rs1008375 1.000 rs6449323 chr4:17683916 A/T cg04450456 chr4:17643702 FAM184B 0.36 5.81 0.31 1.47e-8 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs4664293 0.585 rs35293435 chr2:160518907 T/C cg08347373 chr2:160653686 CD302 0.39 6.58 0.34 1.91e-10 Monocyte percentage of white cells; CRC cis rs10751667 1.000 rs10902233 chr11:925510 A/G ch.11.42038R chr11:967971 AP2A2 0.7 11.77 0.54 6.25e-27 Alzheimer's disease (late onset); CRC cis rs6121246 0.609 rs6060843 chr20:30297047 G/C cg18721089 chr20:30220636 NA -0.32 -5.73 -0.3 2.23e-8 Mean corpuscular hemoglobin; CRC cis rs8040855 0.599 rs1964724 chr15:85726500 G/C cg04831495 chr15:85060580 GOLGA6L5 0.37 5.7 0.3 2.71e-8 Bulimia nervosa; CRC cis rs10871290 0.881 rs3863436 chr16:74468038 T/C cg01733217 chr16:74700730 RFWD3 -0.71 -11.45 -0.53 9.05e-26 Breast cancer; CRC cis rs35883536 0.647 rs10875328 chr1:101169328 C/T cg14515779 chr1:101123966 NA 0.34 5.7 0.3 2.73e-8 Monocyte count; CRC cis rs9311676 0.632 rs11924677 chr3:58420542 T/C cg06643156 chr3:58380774 PXK 0.42 6.47 0.34 3.46e-10 Systemic lupus erythematosus; CRC cis rs11098499 0.865 rs4001305 chr4:120359236 G/T cg24375607 chr4:120327624 NA 0.52 8.0 0.4 2.09e-14 Corneal astigmatism; CRC cis rs4638749 0.677 rs13398290 chr2:108833853 G/T cg25838818 chr2:108905173 SULT1C2 -0.34 -5.82 -0.31 1.4e-8 Blood pressure; CRC cis rs2070488 0.965 rs7372386 chr3:38484175 C/G cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.85 15.82 0.66 2.55e-42 Electrocardiographic conduction measures; CRC cis rs1448094 0.512 rs7134732 chr12:86241908 T/C cg19622623 chr12:86230825 RASSF9 -0.41 -6.7 -0.35 9.04e-11 Major depressive disorder; CRC cis rs728616 0.867 rs75447386 chr10:81739647 G/A cg11900509 chr10:81946545 ANXA11 -0.68 -6.82 -0.35 4.39e-11 Chronic obstructive pulmonary disease-related biomarkers; CRC trans rs10983614 1.000 rs7867776 chr9:120072627 A/G cg02066222 chr1:114354688 RSBN1 0.47 6.45 0.34 4.01e-10 Survival in pancreatic cancer; CRC cis rs965469 1.000 rs6051790 chr20:3342994 C/T cg25506879 chr20:3388711 C20orf194 -0.39 -5.75 -0.3 2.07e-8 IFN-related cytopenia; CRC cis rs853679 0.517 rs1947863 chr6:28099344 G/A cg15845792 chr6:28175446 NA 1.01 13.54 0.6 1.59e-33 Depression; CRC cis rs4927850 1.000 rs4927850 chr3:195751630 C/T cg12923728 chr3:195709715 SDHAP1 0.69 10.65 0.51 6.08e-23 Pancreatic cancer; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg18629615 chr19:18794107 CRTC1 0.43 6.15 0.32 2.27e-9 Intelligence (multi-trait analysis); CRC cis rs9368481 0.761 rs9379952 chr6:26987900 A/T cg07220782 chr6:26987966 LOC100270746;C6orf41 -0.44 -6.22 -0.32 1.49e-9 Autism spectrum disorder or schizophrenia; CRC cis rs7618915 0.547 rs4687638 chr3:52651966 A/C cg11645453 chr3:52864694 ITIH4 0.36 6.39 0.33 5.61e-10 Bipolar disorder; CRC cis rs8062405 0.755 rs111693583 chr16:28583610 C/T cg05139728 chr16:28306816 SBK1 -0.38 -6.23 -0.32 1.41e-9 Cognitive ability (multi-trait analysis);Cognitive ability; CRC cis rs1129187 0.755 rs28868299 chr6:42921221 T/G cg02359409 chr6:42947317 PEX6 -0.65 -10.29 -0.49 1.06e-21 Alzheimer's disease in APOE e4+ carriers; CRC cis rs28386778 0.897 rs6504176 chr17:61811920 T/C cg25654072 chr17:61904446 PSMC5;FTSJ3 0.72 11.02 0.52 2.9e-24 Prudent dietary pattern; CRC cis rs6582630 0.555 rs10785454 chr12:38476260 C/T cg13010199 chr12:38710504 ALG10B 0.49 6.49 0.34 3.13e-10 Drug-induced liver injury (flucloxacillin); CRC cis rs10857712 0.754 rs2297033 chr10:135234848 C/T cg01444801 chr10:135216882 MTG1 -0.55 -7.82 -0.4 7.4e-14 Systemic lupus erythematosus; CRC cis rs12541635 0.801 rs12155858 chr8:107105205 G/A cg10147462 chr8:107024639 NA -0.39 -6.05 -0.32 3.92e-9 Age of smoking initiation; CRC cis rs7659604 1.000 rs6814995 chr4:122664963 A/T cg20573242 chr4:122745356 CCNA2 -0.4 -5.8 -0.3 1.56e-8 Type 2 diabetes; CRC cis rs514406 0.825 rs497535 chr1:53284677 A/G cg27535305 chr1:53392650 SCP2 0.39 7.01 0.36 1.34e-11 Monocyte count; CRC cis rs7113874 0.589 rs7120065 chr11:8484896 C/T cg20771178 chr11:8615675 STK33 -0.34 -5.67 -0.3 3.07e-8 Body mass index in physically active individuals;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs28386778 0.897 rs2044125 chr17:61863184 A/C cg11494091 chr17:61959527 GH2 -0.59 -9.99 -0.48 1.07e-20 Prudent dietary pattern; CRC cis rs28386778 0.897 rs10221279 chr17:61806138 A/G cg06873352 chr17:61820015 STRADA 0.79 14.79 0.63 2.66e-38 Prudent dietary pattern; CRC cis rs642743 0.517 rs157077 chr10:106037894 C/T cg27365978 chr10:106093659 ITPRIP -0.41 -6.32 -0.33 8.47e-10 Left ventricular obstructive tract defect (maternal effect); CRC cis rs17376456 0.877 rs10476598 chr5:93367281 C/T cg21475434 chr5:93447410 FAM172A -0.73 -8.03 -0.4 1.74e-14 Diabetic retinopathy; CRC cis rs12913538 0.890 rs4326998 chr15:62896609 A/G cg09983546 chr15:62884068 NA 0.54 7.9 0.4 4.36e-14 Sleep depth; CRC cis rs8060686 0.641 rs28508024 chr16:68126606 T/C cg08314208 chr16:67682810 RLTPR -0.49 -5.87 -0.31 1.06e-8 HDL cholesterol;Metabolic syndrome; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg01903903 chr12:82752704 CCDC59;C12orf26 0.38 6.33 0.33 8.14e-10 Liver disease severity in Alagille syndrome; CRC trans rs7618501 1.000 rs6446295 chr3:49809063 G/T cg21582582 chr3:182698605 DCUN1D1 0.56 8.34 0.42 2.09e-15 Intelligence (multi-trait analysis); CRC cis rs9486715 0.867 rs3849199 chr6:97049191 T/C cg18709589 chr6:96969512 KIAA0776 -0.5 -7.55 -0.38 4.38e-13 Headache; CRC cis rs7089973 0.668 rs7077148 chr10:116644896 A/G cg23260525 chr10:116636907 FAM160B1 0.36 7.96 0.4 2.81e-14 Bipolar disorder or attention deficit hyperactivity disorder; CRC cis rs539096 0.500 rs2906457 chr1:44338575 A/C cg12908607 chr1:44402522 ARTN -0.55 -10.1 -0.49 4.61e-21 Intelligence (multi-trait analysis); CRC cis rs501916 0.634 rs1561480 chr15:48070050 C/G cg16110827 chr15:48056943 SEMA6D -0.45 -6.48 -0.34 3.43e-10 Inflammatory bowel disease;Ulcerative colitis; CRC cis rs294883 0.858 rs1394231 chr6:159718921 C/T cg14500486 chr6:159655392 FNDC1 -0.35 -5.75 -0.3 2.09e-8 Coronary artery disease; CRC cis rs4713118 0.824 rs9468223 chr6:27740666 C/T cg15786705 chr6:28176104 NA 0.56 7.3 0.37 2.19e-12 Parkinson's disease; CRC cis rs28655083 0.912 rs2171097 chr16:77085037 C/G cg01753188 chr16:77233325 SYCE1L;MON1B -0.54 -7.45 -0.38 8.37e-13 Lobe attachment (rater-scored or self-reported); CRC cis rs11677416 1.000 rs34015482 chr2:113525745 A/G cg27083787 chr2:113543245 IL1A 0.49 6.88 0.35 3.07e-11 Response to antipsychotic treatment in schizophrenia (working memory); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg21042902 chr5:176873577 PRR7 0.39 6.47 0.34 3.54e-10 Liver disease severity in Alagille syndrome; CRC cis rs11122272 0.705 rs2486742 chr1:231507254 G/A cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.51 -7.66 -0.39 2.06e-13 Hemoglobin concentration; CRC cis rs1448094 0.512 rs7308229 chr12:86239849 A/T cg19622623 chr12:86230825 RASSF9 0.41 6.57 0.34 1.93e-10 Major depressive disorder; CRC trans rs875971 0.660 rs2191268 chr7:66110224 C/T cg02045355 chr6:26365194 BTN3A2 -0.38 -6.06 -0.32 3.73e-9 Aortic root size; CRC cis rs13108904 0.901 rs7673398 chr4:1300077 G/A cg20887711 chr4:1340912 KIAA1530 0.43 6.47 0.34 3.61e-10 Obesity-related traits; CRC cis rs9400239 0.547 rs473268 chr6:109019323 C/A cg11073813 chr6:109029018 NA -0.39 -6.11 -0.32 2.77e-9 Waist circumference;Body mass index;BMI (adjusted for smoking behaviour); CRC cis rs1007738 0.507 rs7940240 chr11:47203068 T/C cg19486271 chr11:47235900 DDB2 -0.44 -5.94 -0.31 7.12e-9 Bone mineral density (hip); CRC cis rs1044826 0.619 rs7375091 chr3:139090389 T/A cg00490450 chr3:139108681 COPB2 -0.48 -7.21 -0.37 3.77e-12 Obesity-related traits; CRC cis rs1348850 0.574 rs2365617 chr2:178421934 C/A cg27490568 chr2:178487706 NA 0.66 7.78 0.39 9.36e-14 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs12824058 0.844 rs7956408 chr12:130807547 A/T cg24838063 chr12:130822603 PIWIL1 -0.44 -6.92 -0.36 2.35e-11 Menopause (age at onset); CRC cis rs798554 0.757 rs1182198 chr7:2862906 C/T cg14895029 chr7:2775587 GNA12 -0.44 -6.28 -0.33 1.05e-9 Height; CRC cis rs2153535 0.580 rs9406158 chr6:8464152 C/T cg07606381 chr6:8435919 SLC35B3 0.67 10.7 0.51 4.01e-23 Motion sickness; CRC cis rs8044995 0.636 rs117761434 chr16:68254196 G/A cg09835421 chr16:68378352 PRMT7 -0.6 -5.76 -0.3 1.93e-8 Schizophrenia; CRC cis rs34172651 0.517 rs11862923 chr16:24767303 G/T cg06505273 chr16:24850292 NA 0.52 6.7 0.35 9.01e-11 Intelligence (multi-trait analysis); CRC trans rs916888 0.773 rs538628 chr17:44787313 G/C cg22433210 chr17:43662623 NA 0.99 10.09 0.49 4.77e-21 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs11098499 0.863 rs6534141 chr4:120485223 A/T cg24375607 chr4:120327624 NA 0.48 7.24 0.37 3.13e-12 Corneal astigmatism; CRC cis rs2836950 0.509 rs4816618 chr21:40599529 G/A cg17971929 chr21:40555470 PSMG1 -0.61 -8.92 -0.44 3.38e-17 Menarche (age at onset); CRC trans rs1814175 0.630 rs1722019 chr11:49904102 G/A cg03929089 chr4:120376271 NA -0.75 -12.4 -0.56 3.21e-29 Height; CRC cis rs208515 0.525 rs1484577 chr6:66688397 A/G cg07460842 chr6:66804631 NA 0.93 11.84 0.55 3.43e-27 Exhaled nitric oxide levels; CRC cis rs34172651 0.517 rs1465423 chr16:24772680 C/G cg00339695 chr16:24857497 SLC5A11 -0.45 -9.46 -0.46 6.18e-19 Intelligence (multi-trait analysis); CRC cis rs477895 0.713 rs2282490 chr11:63962152 T/C cg18225595 chr11:63971243 STIP1 0.61 8.14 0.41 7.99e-15 Mean platelet volume; CRC cis rs9908102 0.740 rs56375019 chr17:12909790 G/A cg26162695 chr17:12921313 ELAC2 0.43 5.81 0.31 1.48e-8 Schizophrenia; CRC cis rs12368653 0.666 rs701007 chr12:58113416 C/A cg00700412 chr12:58011837 NA 0.37 5.69 0.3 2.8e-8 Multiple sclerosis; CRC cis rs8062405 1.000 rs4788099 chr16:28855727 A/G cg08761264 chr16:28874980 SH2B1 -0.44 -5.84 -0.31 1.28e-8 Cognitive ability (multi-trait analysis);Cognitive ability; CRC trans rs60843830 1.000 rs62114497 chr2:214837 G/A cg11347411 chr7:150020925 ACTR3C;LRRC61 0.58 8.67 0.43 2.03e-16 Spherical equivalent (joint analysis main effects and education interaction); CRC cis rs13217239 0.646 rs10946891 chr6:26973215 T/C cg12292205 chr6:26970375 C6orf41 0.56 9.32 0.46 1.78e-18 Schizophrenia; CRC cis rs589448 0.872 rs315111 chr12:69784695 G/A cg14784868 chr12:69753453 YEATS4 0.9 17.3 0.69 3.68e-48 Cerebrospinal fluid biomarker levels; CRC cis rs977987 0.778 rs12445726 chr16:75465575 C/T cg03315344 chr16:75512273 CHST6 0.55 9.12 0.45 7.56e-18 Dupuytren's disease; CRC cis rs9549260 0.564 rs7998086 chr13:41268924 T/C cg21288729 chr13:41239152 FOXO1 0.45 6.96 0.36 1.8e-11 Red blood cell count; CRC cis rs34375054 0.526 rs34764657 chr12:125679639 A/G cg02766259 chr12:125626809 AACS -0.46 -7.74 -0.39 1.21e-13 Post bronchodilator FEV1/FVC ratio; CRC trans rs3780486 1.000 rs10813951 chr9:33128021 C/T cg20290983 chr6:43655470 MRPS18A -1.03 -16.91 -0.68 1.31e-46 IgG glycosylation; CRC cis rs977987 0.864 rs40446 chr16:75496658 T/C cg03315344 chr16:75512273 CHST6 -0.58 -9.63 -0.47 1.69e-19 Dupuytren's disease; CRC cis rs6844506 0.565 rs10008153 chr4:185227184 C/T cg18317788 chr4:185205197 NA -0.39 -6.2 -0.32 1.72e-9 Gestational age at birth in premature rupture of membrane-initiated deliveries (child effect); CRC cis rs11098499 0.775 rs10021601 chr4:120282563 G/A cg24375607 chr4:120327624 NA 0.48 7.48 0.38 6.87e-13 Corneal astigmatism; CRC trans rs11098499 0.874 rs17839089 chr4:120111069 A/G cg25214090 chr10:38739885 LOC399744 0.52 7.73 0.39 1.34e-13 Corneal astigmatism; CRC cis rs6840360 0.615 rs6836249 chr4:152465829 T/G cg09659197 chr4:152720779 NA 0.31 5.64 0.3 3.6e-8 Intelligence (multi-trait analysis); CRC cis rs889312 0.521 rs12651942 chr5:56088484 C/T cg03609598 chr5:56110824 MAP3K1 -0.43 -6.06 -0.32 3.7e-9 Breast cancer;Breast cancer (early onset); CRC cis rs2302190 0.882 rs8072873 chr17:56669049 G/C cg12560992 chr17:57184187 TRIM37 0.53 6.17 0.32 1.98e-9 Vitamin D levels; CRC cis rs172166 0.769 rs149965 chr6:28018689 T/A cg23161317 chr6:28129485 ZNF389 0.44 6.3 0.33 9.6e-10 Cardiac Troponin-T levels; CRC cis rs77861329 1.000 rs171294 chr3:52203599 C/G cg08692210 chr3:52188851 WDR51A 0.87 8.16 0.41 7.07e-15 Macrophage inflammatory protein 1b levels; CRC cis rs6076065 0.723 rs6083104 chr20:23366038 C/T cg11657817 chr20:23433608 CST11 0.44 6.63 0.34 1.37e-10 Facial morphology (factor 15, philtrum width); CRC cis rs1395 0.778 rs4665959 chr2:27443256 C/T cg14242246 chr2:27434262 C2orf28;SLC5A6 0.42 7.85 0.4 5.74e-14 Blood metabolite levels; CRC cis rs6860806 0.507 rs582490 chr5:131710095 G/A cg12564285 chr5:131593104 PDLIM4 -0.45 -7.51 -0.38 5.66e-13 Breast cancer; CRC cis rs6732160 0.613 rs58317144 chr2:73388153 C/T cg01422370 chr2:73384389 NA 0.39 6.13 0.32 2.56e-9 Intelligence (multi-trait analysis); CRC cis rs3996993 0.597 rs62412889 chr6:52703158 G/A cg20803780 chr6:52668592 GSTA1 0.39 6.59 0.34 1.76e-10 Hemoglobin concentration; CRC cis rs10504229 0.679 rs7839948 chr8:58130607 A/G cg21724239 chr8:58056113 NA 0.49 6.81 0.35 4.75e-11 Developmental language disorder (linguistic errors); CRC cis rs2404602 0.679 rs12899871 chr15:76757347 T/C cg03037974 chr15:76606532 NA 0.73 13.13 0.59 5.83e-32 Blood metabolite levels; CRC cis rs365302 1.000 rs474108 chr6:159648154 A/G cg14500486 chr6:159655392 FNDC1 0.44 6.82 0.35 4.31e-11 Coronary heart disease; CRC cis rs2252790 1.000 rs2252790 chr6:116663323 G/A cg18764771 chr6:116381957 FRK -0.22 -5.8 -0.3 1.59e-8 Fast beta electroencephalogram; CRC cis rs1862618 0.853 rs252910 chr5:56192983 G/A cg03609598 chr5:56110824 MAP3K1 -0.86 -9.91 -0.48 2.03e-20 Initial pursuit acceleration; CRC cis rs1552244 1.000 rs57631744 chr3:10118962 T/C cg02579736 chr3:10068473 FANCD2;CIDECP 0.97 13.2 0.59 3.17e-32 Alzheimer's disease; CRC cis rs7772486 0.875 rs7739371 chr6:146424353 C/G cg13319975 chr6:146136371 FBXO30 -0.4 -6.15 -0.32 2.23e-9 Lobe attachment (rater-scored or self-reported); CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg00071751 chr10:91461194 KIF20B 0.51 7.02 0.36 1.27e-11 Anxiety disorder; CRC cis rs6598955 0.640 rs4233460 chr1:26633387 A/G cg00852783 chr1:26633632 UBXN11 0.4 6.49 0.34 3.11e-10 Obesity-related traits; CRC cis rs1018836 0.923 rs13267989 chr8:91581648 C/T cg16814680 chr8:91681699 NA -0.73 -11.9 -0.55 2.12e-27 Ejection fraction in Tripanosoma cruzi seropositivity; CRC cis rs7223966 1.000 rs9912201 chr17:61763208 A/G cg05941027 chr17:61774174 LIMD2 0.35 6.12 0.32 2.64e-9 Hip circumference adjusted for BMI;Body mass index; CRC cis rs6840360 0.642 rs2709816 chr4:152380269 T/C cg09659197 chr4:152720779 NA 0.33 6.46 0.34 3.69e-10 Intelligence (multi-trait analysis); CRC cis rs6546550 0.835 rs13002091 chr2:70118388 C/T cg02498382 chr2:70120550 SNRNP27 -0.54 -9.16 -0.45 5.56e-18 Prevalent atrial fibrillation; CRC cis rs7617773 0.780 rs3197223 chr3:48335857 C/T cg11946769 chr3:48343235 NME6 0.73 9.93 0.48 1.73e-20 Coronary artery disease; CRC cis rs7746199 0.668 rs34864796 chr6:27459923 G/A cg26587870 chr6:27730563 NA -0.67 -6.29 -0.33 1.04e-9 Gait speed in old age;Autism spectrum disorder or schizophrenia; CRC cis rs4285028 0.898 rs4305455 chr3:121619774 T/C cg11130432 chr3:121712080 ILDR1 -0.5 -6.35 -0.33 7.22e-10 Multiple sclerosis; CRC trans rs2294025 0.932 rs7816892 chr8:134169898 A/G cg19857114 chr3:176741225 TBL1XR1 0.4 6.41 0.33 4.93e-10 Graves' disease; CRC cis rs9311474 0.508 rs6805156 chr3:52609362 T/C cg08222913 chr3:52553049 STAB1 -0.34 -6.39 -0.33 5.78e-10 Electroencephalogram traits; CRC cis rs7615952 0.576 rs2276726 chr3:125826287 C/G cg02807482 chr3:125708958 NA -0.41 -5.61 -0.3 4.25e-8 Blood pressure (smoking interaction); CRC cis rs9326248 0.559 rs573549 chr11:116736679 A/G cg01368799 chr11:117014884 PAFAH1B2 0.4 6.22 0.32 1.53e-9 Blood protein levels; CRC trans rs3733585 0.781 rs13103690 chr4:9972778 T/G cg26043149 chr18:55253948 FECH -0.52 -8.17 -0.41 6.72e-15 Cleft plate (environmental tobacco smoke interaction); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg06296021 chr5:133702588 CDKL3 0.43 6.29 0.33 9.86e-10 Response to antipsychotic treatment; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg19927028 chr5:64777838 ADAMTS6 0.52 7.44 0.38 8.87e-13 Response to antipsychotic treatment; CRC cis rs739401 0.527 rs423236 chr11:3065916 C/T cg05729581 chr11:3078854 CARS -0.6 -8.76 -0.43 1.07e-16 Longevity; CRC cis rs6662572 0.737 rs11211214 chr1:46347328 C/T cg03123370 chr1:45965343 CCDC163P;MMACHC -0.44 -5.67 -0.3 3.11e-8 Blood protein levels; CRC cis rs9325144 0.554 rs1906264 chr12:38739490 A/G cg26384229 chr12:38710491 ALG10B 0.52 7.75 0.39 1.15e-13 Morning vs. evening chronotype; CRC cis rs9399135 0.967 rs13218642 chr6:135309940 A/G cg24558204 chr6:135376177 HBS1L 0.49 7.74 0.39 1.21e-13 Red blood cell count; CRC cis rs9462027 0.628 rs6905393 chr6:34776626 T/C cg07306190 chr6:34760872 UHRF1BP1 -0.34 -5.95 -0.31 6.95e-9 Systemic lupus erythematosus; CRC cis rs7412746 0.658 rs7526489 chr1:150726238 C/T cg15448220 chr1:150897856 SETDB1 0.54 7.59 0.39 3.34e-13 Melanoma; CRC cis rs6456156 0.819 rs4709148 chr6:167521676 T/C cg07741184 chr6:167504864 NA 0.35 6.12 0.32 2.68e-9 Primary biliary cholangitis; CRC cis rs7208859 0.623 rs79607958 chr17:28934548 T/G cg13385521 chr17:29058706 SUZ12P 0.62 6.66 0.34 1.13e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs10256972 0.521 rs7811577 chr7:1102829 C/G cg03923535 chr7:1197113 ZFAND2A 0.52 7.67 0.39 2.01e-13 Longevity;Endometriosis; CRC cis rs644799 0.930 rs3802764 chr11:95514599 T/A cg03916912 chr11:95522834 CEP57;FAM76B 0.96 18.02 0.7 5.41e-51 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs853679 0.723 rs9366718 chr6:28205502 A/T cg21251018 chr6:28226885 NKAPL 0.52 6.06 0.32 3.7e-9 Depression; CRC cis rs2836974 0.899 rs114399588 chr21:40653958 G/A cg17971929 chr21:40555470 PSMG1 0.74 10.05 0.48 6.48e-21 Cognitive function; CRC cis rs12410462 1.000 rs1587158 chr1:227658753 G/A cg04117972 chr1:227635322 NA -0.51 -5.83 -0.31 1.32e-8 Major depressive disorder; CRC cis rs13315871 0.929 rs13097873 chr3:58267924 C/T cg20936604 chr3:58311152 NA -0.59 -5.66 -0.3 3.23e-8 Cholesterol, total; CRC cis rs910316 0.789 rs12894419 chr14:75471802 C/T cg08847533 chr14:75593920 NEK9 0.86 14.88 0.63 1.23e-38 Height; CRC cis rs977987 0.864 rs37592 chr16:75496791 G/C cg03315344 chr16:75512273 CHST6 -0.58 -9.63 -0.47 1.69e-19 Dupuytren's disease; CRC trans rs2727020 0.521 rs10839299 chr11:49573981 C/T cg03929089 chr4:120376271 NA -0.76 -10.09 -0.49 4.98e-21 Coronary artery disease; CRC cis rs4974559 0.501 rs1250129 chr4:1254930 C/T cg02980000 chr4:1222292 CTBP1 0.54 6.3 0.33 9.38e-10 Systolic blood pressure; CRC cis rs17152411 1.000 rs7082846 chr10:126593310 C/A cg07906193 chr10:126599966 NA 0.58 6.52 0.34 2.69e-10 Height; CRC cis rs72945132 0.882 rs12295111 chr11:70131882 C/A cg14191688 chr11:70257035 CTTN 0.4 5.62 0.3 4.07e-8 Coronary artery disease; CRC cis rs6604026 0.666 rs11164830 chr1:93356823 C/A cg17283838 chr1:93427260 FAM69A -0.5 -6.92 -0.36 2.36e-11 Multiple sclerosis; CRC cis rs6543140 0.964 rs6543136 chr2:103065547 G/A cg09003973 chr2:102972529 NA 0.43 6.05 0.32 4.05e-9 Blood protein levels; CRC trans rs35110281 0.837 rs2838340 chr21:45076373 A/G cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.39 6.26 0.33 1.2e-9 Mean corpuscular volume; CRC cis rs875971 0.862 rs6964437 chr7:65686444 A/G cg12463550 chr7:65579703 CRCP -0.51 -6.85 -0.35 3.54e-11 Aortic root size; CRC cis rs4594175 0.677 rs7149846 chr14:51739654 A/C cg23942311 chr14:51606299 NA 0.47 6.97 0.36 1.78e-11 Cancer; CRC trans rs951252 0.504 rs11734405 chr4:146081096 C/T cg24351916 chr3:39452635 SNORA62;RPSA -0.48 -6.26 -0.33 1.17e-9 Hip circumference; CRC cis rs514406 0.644 rs7529978 chr1:53204705 G/A cg24675658 chr1:53192096 ZYG11B 0.72 11.92 0.55 1.85e-27 Monocyte count; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg21548788 chr4:77997565 CCNI 0.46 6.48 0.34 3.38e-10 Response to antipsychotic treatment; CRC cis rs2859741 0.647 rs548661 chr1:37479392 T/G cg09363841 chr1:37513479 NA -0.56 -9.48 -0.46 5.07e-19 Forced expiratory volume in 1 second (environmental tobacco smoke interaction); CRC cis rs4332037 0.624 rs58169303 chr7:1883274 T/C cg23378565 chr7:2036160 MAD1L1 -0.41 -6.28 -0.33 1.04e-9 Bipolar disorder; CRC cis rs7615952 0.599 rs60847438 chr3:125746005 T/C cg02772935 chr3:125709198 NA -0.5 -5.71 -0.3 2.53e-8 Blood pressure (smoking interaction); CRC cis rs6479527 0.904 rs6479529 chr9:96883386 T/C cg14459158 chr9:96720562 NA 0.37 6.14 0.32 2.38e-9 Esophageal adenocarcinoma; CRC cis rs9311474 0.507 rs4687644 chr3:52746541 T/G cg05573699 chr3:52720067 GNL3;PBRM1 -0.48 -6.95 -0.36 2.01e-11 Electroencephalogram traits; CRC cis rs11212617 0.967 rs4753833 chr11:108057430 G/A cg14761454 chr11:108092087 ATM;NPAT 0.4 5.93 0.31 7.67e-9 Response to metformin in type 2 diabetes (glycemic); CRC trans rs11098499 0.644 rs7676296 chr4:120555687 A/G cg25214090 chr10:38739885 LOC399744 0.58 9.18 0.45 4.73e-18 Corneal astigmatism; CRC cis rs6951245 0.935 rs113365567 chr7:1108785 T/C cg21664854 chr7:1097933 C7orf50;GPR146 0.78 8.86 0.44 5.03e-17 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs4076764 0.958 rs6691127 chr1:163384831 T/C cg06092702 chr1:163392909 NA -0.55 -8.6 -0.43 3.28e-16 Motion sickness; CRC trans rs12599106 0.660 rs12919333 chr16:34991336 C/T cg05064044 chr6:292385 DUSP22 -0.74 -10.52 -0.5 1.7e-22 Menopause (age at onset); CRC cis rs1552244 0.554 rs6762594 chr3:9995516 G/A cg08888203 chr3:10149979 C3orf24 0.47 7.23 0.37 3.47e-12 Alzheimer's disease; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg21180178 chr1:10093010 UBE4B 0.46 6.71 0.35 8.27e-11 Intelligence (multi-trait analysis); CRC cis rs1046896 0.514 rs9894705 chr17:80823758 A/C cg19046167 chr17:80928561 B3GNTL1 -0.5 -7.2 -0.37 4.1e-12 Glycated hemoglobin levels; CRC cis rs35110281 0.748 rs4997353 chr21:45002329 A/C cg04455712 chr21:45112962 RRP1B 0.4 7.79 0.39 8.72e-14 Mean corpuscular volume; CRC cis rs7223966 1.000 rs2013288 chr17:61785904 C/T cg05941027 chr17:61774174 LIMD2 0.35 6.24 0.33 1.32e-9 Hip circumference adjusted for BMI;Body mass index; CRC trans rs2243480 1.000 rs6964530 chr7:65718851 G/C cg10756647 chr7:56101905 PSPH -0.74 -7.57 -0.39 3.76e-13 Diabetic kidney disease; CRC trans rs2727020 0.658 rs4980431 chr11:49350071 G/T cg11707556 chr5:10655725 ANKRD33B -0.36 -6.7 -0.35 8.88e-11 Coronary artery disease; CRC cis rs10256972 0.552 rs2949192 chr7:1203841 C/T cg09177884 chr7:1199841 ZFAND2A -0.5 -7.5 -0.38 6.16e-13 Longevity;Endometriosis; CRC cis rs1129187 0.755 rs2274517 chr6:42932715 A/G cg26304593 chr6:42947056 PEX6 0.45 6.58 0.34 1.86e-10 Alzheimer's disease in APOE e4+ carriers; CRC trans rs11343 0.675 rs7359333 chr16:19262344 A/T cg14094063 chr7:140624470 BRAF -0.46 -6.01 -0.31 4.82e-9 Parkinson's disease; CRC cis rs3096299 0.509 rs4785691 chr16:89597221 A/G cg00750074 chr16:89608354 SPG7 -0.55 -8.44 -0.42 1.01e-15 Multiple myeloma (IgH translocation); CRC cis rs7605827 0.930 rs2287273 chr2:15658523 T/C cg19274914 chr2:15703543 NA 0.39 5.89 0.31 9.8e-9 Educational attainment (years of education); CRC cis rs854765 0.927 rs12943914 chr17:17980671 A/G cg16928487 chr17:17741425 SREBF1 -0.52 -8.65 -0.43 2.24e-16 Total body bone mineral density; CRC cis rs10131894 0.635 rs174997 chr14:75434806 G/A cg11812906 chr14:75593930 NEK9 -0.49 -7.36 -0.38 1.46e-12 Coronary artery disease; CRC cis rs9381040 0.610 rs6919961 chr6:41020361 T/A cg25110423 chr6:41068646 NFYA;LOC221442 -0.39 -5.97 -0.31 6.28e-9 Alzheimer's disease (late onset); CRC cis rs11997175 0.624 rs7465686 chr8:33718321 G/A cg04338863 chr8:33670619 NA 0.44 6.49 0.34 3.25e-10 Body mass index; CRC cis rs28386778 0.897 rs7207005 chr17:61860355 A/G cg06873352 chr17:61820015 STRADA 0.8 15.29 0.64 2.98e-40 Prudent dietary pattern; CRC cis rs3733585 0.673 rs4459990 chr4:9954005 T/C cg11266682 chr4:10021025 SLC2A9 -0.47 -9.62 -0.47 1.76e-19 Cleft plate (environmental tobacco smoke interaction); CRC cis rs10504229 0.728 rs55812114 chr8:58157453 C/T cg24829409 chr8:58192753 C8orf71 -0.6 -8.07 -0.41 1.29e-14 Developmental language disorder (linguistic errors); CRC cis rs9814567 0.806 rs4074522 chr3:134325626 A/G cg06541857 chr3:134203789 ANAPC13;CEP63 0.37 5.68 0.3 3.03e-8 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs6570726 0.935 rs398060 chr6:145841515 C/T cg05347473 chr6:146136440 FBXO30 -0.37 -5.64 -0.3 3.7e-8 Lobe attachment (rater-scored or self-reported); CRC cis rs4285028 0.747 rs7623901 chr3:121529011 A/G cg20356878 chr3:121714668 ILDR1 0.47 6.23 0.32 1.45e-9 Multiple sclerosis; CRC cis rs3741151 0.656 rs56884659 chr11:73252947 C/G cg17517138 chr11:73019481 ARHGEF17 0.92 7.18 0.37 4.8e-12 GIP levels in response to oral glucose tolerance test (120 minutes); CRC cis rs736408 0.509 rs1108842 chr3:52720080 A/C cg05573699 chr3:52720067 GNL3;PBRM1 -0.55 -8.42 -0.42 1.15e-15 Bipolar disorder; CRC trans rs7718446 0.622 rs12653353 chr5:145780135 A/G cg27662633 chr7:30395138 ZNRF2 0.33 6.09 0.32 3.18e-9 Migraine without aura; CRC cis rs2228479 0.867 rs76885005 chr16:89966668 A/G cg04013166 chr16:89971882 TCF25 0.58 5.9 0.31 8.96e-9 Skin colour saturation; CRC cis rs763014 0.966 rs4984903 chr16:680695 A/G cg04562611 chr16:615315 C16orf11 0.37 6.16 0.32 2.06e-9 Height; CRC cis rs11676348 0.901 rs7562334 chr2:219003360 G/A cg00012203 chr2:219082015 ARPC2 -0.38 -5.81 -0.3 1.49e-8 Ulcerative colitis; CRC cis rs875971 0.862 rs6964437 chr7:65686444 A/G cg00343986 chr7:65444356 GUSB -0.47 -6.45 -0.33 4.05e-10 Aortic root size; CRC trans rs62103177 0.810 rs62103195 chr18:77629693 T/C cg05926928 chr17:57297772 GDPD1 1.1 10.17 0.49 2.54e-21 Opioid sensitivity; CRC trans rs916888 0.610 rs142167 chr17:44795234 C/T cg10053473 chr17:62856997 LRRC37A3 0.62 8.18 0.41 6.25e-15 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs10504229 0.593 rs79874994 chr8:57993709 C/A cg02725872 chr8:58115012 NA -0.53 -7.09 -0.36 8.33e-12 Developmental language disorder (linguistic errors); CRC cis rs1707322 1.000 rs4660318 chr1:46334876 A/G cg06784218 chr1:46089804 CCDC17 0.51 8.95 0.44 2.75e-17 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs9311474 0.713 rs352167 chr3:52238656 C/T cg18099408 chr3:52552593 STAB1 0.34 5.61 0.3 4.36e-8 Electroencephalogram traits; CRC cis rs79349575 0.783 rs12602933 chr17:47029280 G/C cg22482690 chr17:47019901 SNF8 0.5 8.26 0.41 3.58e-15 Type 2 diabetes; CRC cis rs11676348 0.935 rs4674250 chr2:218977531 G/A cg00012203 chr2:219082015 ARPC2 -0.38 -5.8 -0.3 1.57e-8 Ulcerative colitis; CRC cis rs317689 0.690 rs570256 chr12:69662929 A/T cg14784868 chr12:69753453 YEATS4 0.44 5.66 0.3 3.28e-8 Response to diuretic therapy; CRC cis rs7552404 1.000 rs7533888 chr1:76160449 A/C cg10523679 chr1:76189770 ACADM 0.83 11.55 0.54 4.04e-26 Blood metabolite levels;Acylcarnitine levels; CRC cis rs11168351 0.926 rs10875719 chr12:48411158 T/C cg00601486 chr12:48723148 H1FNT 0.3 5.69 0.3 2.82e-8 Bipolar disorder and schizophrenia; CRC cis rs16921914 0.565 rs286650 chr11:31230207 T/C cg14844989 chr11:31128820 NA -0.34 -6.02 -0.32 4.55e-9 Bone mineral density (spine); CRC cis rs875971 0.522 rs2008188 chr7:65429013 G/C cg00343986 chr7:65444356 GUSB 0.57 8.63 0.43 2.72e-16 Aortic root size; CRC cis rs77633900 0.772 rs77582696 chr15:76669153 A/G cg21673338 chr15:77095150 SCAPER -0.69 -6.08 -0.32 3.31e-9 Non-glioblastoma glioma;Glioma; CRC cis rs747650 0.504 rs7945558 chr11:46957808 G/A cg19486271 chr11:47235900 DDB2 -0.43 -6.64 -0.34 1.27e-10 Acne (severe); CRC cis rs4665809 0.652 rs2241739 chr2:26411894 C/T cg04944784 chr2:26401820 FAM59B -0.84 -11.23 -0.53 5.23e-25 Gut microbiome composition (summer); CRC cis rs2303745 0.544 rs12710308 chr19:17395879 T/A cg04248312 chr19:17393744 ANKLE1 -0.95 -14.46 -0.62 5.12e-37 Systemic lupus erythematosus; CRC cis rs9916302 0.904 rs10491128 chr17:37551988 G/A cg15445000 chr17:37608096 MED1 -0.42 -9.14 -0.45 6.65e-18 Glomerular filtration rate (creatinine); CRC cis rs7927592 0.763 rs1193699 chr11:68249480 C/G cg16797656 chr11:68205561 LRP5 0.51 9.59 0.47 2.22e-19 Total body bone mineral density; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg06567423 chr11:125462867 STT3A 0.41 6.02 0.31 4.77e-9 Intelligence (multi-trait analysis); CRC cis rs6951245 0.935 rs79143504 chr7:1110212 A/G cg18402987 chr7:1209562 NA 0.66 6.83 0.35 4.08e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs11608355 1.000 rs9669684 chr12:109860644 C/T cg19025524 chr12:109796872 NA -0.47 -6.72 -0.35 8e-11 Neuroticism; CRC cis rs9733 0.596 rs72702504 chr1:150635374 G/C cg15448220 chr1:150897856 SETDB1 0.45 6.43 0.33 4.42e-10 Tonsillectomy; CRC cis rs9911578 1.000 rs12602346 chr17:56901713 T/C cg12560992 chr17:57184187 TRIM37 0.92 16.91 0.68 1.29e-46 Intelligence (multi-trait analysis); CRC cis rs208520 1.000 rs12212063 chr6:66985148 C/A cg07460842 chr6:66804631 NA 0.89 11.06 0.52 2.27e-24 Exhaled nitric oxide output; CRC cis rs311392 1.000 rs2666870 chr8:55086427 T/C cg06042504 chr8:55087323 NA -0.44 -6.56 -0.34 2.05e-10 Pelvic organ prolapse (moderate/severe); CRC cis rs11249608 0.636 rs13361077 chr5:178449174 G/C cg01312482 chr5:178451176 ZNF879 -0.36 -6.07 -0.32 3.55e-9 Pubertal anthropometrics; CRC cis rs9584850 0.609 rs7983408 chr13:99155593 G/C cg20487152 chr13:99095054 FARP1 0.44 5.65 0.3 3.44e-8 Neuroticism; CRC cis rs8141529 0.702 rs5762870 chr22:29261159 C/T cg02153584 chr22:29168773 CCDC117 0.5 7.52 0.38 5.43e-13 Lymphocyte counts; CRC cis rs1971762 0.712 rs7302232 chr12:53965423 A/T cg06632207 chr12:54070931 ATP5G2 0.39 6.57 0.34 1.93e-10 Height; CRC trans rs1005277 0.541 rs2505193 chr10:38394638 G/C cg27523141 chr10:43048294 ZNF37B 0.49 7.21 0.37 3.76e-12 Extrinsic epigenetic age acceleration; CRC cis rs853679 0.517 rs9357065 chr6:28129580 T/C cg12172441 chr6:28176163 NA 0.64 7.46 0.38 7.95e-13 Depression; CRC cis rs13191362 0.935 rs66635391 chr6:162964577 G/A cg23758597 chr6:163146217 PARK2 -0.55 -5.62 -0.3 4.13e-8 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC trans rs5756813 0.688 rs34891095 chr22:38126582 C/T cg19894588 chr14:64061835 NA -0.58 -7.64 -0.39 2.45e-13 Optic cup area;Vertical cup-disc ratio; CRC cis rs10504229 1.000 rs1390411 chr8:58194146 C/A cg22535103 chr8:58192502 C8orf71 -0.73 -11.17 -0.52 9.13e-25 Developmental language disorder (linguistic errors); CRC cis rs12760731 0.565 rs11583144 chr1:178222070 C/G cg00404053 chr1:178313656 RASAL2 1.03 10.81 0.51 1.61e-23 Obesity-related traits; CRC cis rs728616 0.867 rs61860042 chr10:81946238 G/A cg11900509 chr10:81946545 ANXA11 -0.71 -7.16 -0.37 5.2e-12 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs7937682 0.632 rs11823089 chr11:111673539 A/G cg09085632 chr11:111637200 PPP2R1B 0.95 15.1 0.64 1.71e-39 Primary sclerosing cholangitis; CRC cis rs763121 0.853 rs6519119 chr22:38989007 C/G cg06544989 chr22:39130855 UNC84B 0.42 6.09 0.32 3.08e-9 Menopause (age at onset); CRC cis rs561341 0.883 rs1034627 chr17:30219569 C/T cg19193384 chr17:30244184 NA -0.46 -5.95 -0.31 6.81e-9 Hip circumference adjusted for BMI; CRC cis rs6866344 0.697 rs11748497 chr5:178130012 C/G cg10224037 chr5:178157518 ZNF354A 0.78 11.33 0.53 2.49e-25 Neutrophil percentage of white cells; CRC cis rs3741151 0.773 rs73548688 chr11:73279544 C/T cg17517138 chr11:73019481 ARHGEF17 0.96 7.44 0.38 8.7e-13 GIP levels in response to oral glucose tolerance test (120 minutes); CRC cis rs62244186 0.659 rs56234157 chr3:44516221 G/A cg11003573 chr3:44754125 ZNF502 -0.34 -5.72 -0.3 2.34e-8 Depressive symptoms; CRC cis rs9322193 0.923 rs11155670 chr6:149966128 C/G cg07701084 chr6:150067640 NUP43 0.6 8.89 0.44 4.09e-17 Lung cancer; CRC cis rs4363385 0.818 rs441229 chr1:153015059 A/C cg25856811 chr1:152973957 SPRR3 -0.27 -7.35 -0.38 1.6e-12 Inflammatory skin disease; CRC cis rs2439831 0.850 rs16950562 chr15:44036364 G/A cg02155558 chr15:43621948 ADAL;LCMT2 0.67 7.38 0.38 1.28e-12 Lung cancer in ever smokers; CRC cis rs736408 0.527 rs2577831 chr3:52628056 C/A cg05573699 chr3:52720067 GNL3;PBRM1 -0.49 -7.45 -0.38 8.52e-13 Bipolar disorder; CRC cis rs6545883 0.524 rs2694618 chr2:61536984 A/G cg10580144 chr2:61372316 C2orf74 0.35 7.79 0.39 8.83e-14 Tuberculosis; CRC cis rs7264396 0.887 rs224354 chr20:34054609 G/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.41 -6.51 -0.34 2.83e-10 Total cholesterol levels; CRC cis rs1008375 0.932 rs13109475 chr4:17677565 C/G cg16339924 chr4:17578868 LAP3 -0.51 -6.69 -0.35 9.6e-11 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs2832191 0.720 rs2832194 chr21:30494250 T/C cg24692254 chr21:30365293 RNF160 -0.69 -11.85 -0.55 3.36e-27 Dental caries; CRC cis rs6570726 0.791 rs443628 chr6:145883484 T/C cg23711669 chr6:146136114 FBXO30 0.77 13.42 0.59 4.55e-33 Lobe attachment (rater-scored or self-reported); CRC cis rs919433 0.963 rs10199410 chr2:198155776 A/T cg20885578 chr2:198174922 NA -0.36 -6.39 -0.33 5.6e-10 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC cis rs877282 1.000 rs11253366 chr10:773386 C/T cg17470449 chr10:769945 NA 0.61 8.84 0.44 5.97e-17 Uric acid levels; CRC cis rs4713118 0.539 rs510987 chr6:27847517 G/A cg25164649 chr6:28176230 NA 0.57 7.84 0.4 6.13e-14 Parkinson's disease; CRC cis rs4973397 0.765 rs13025087 chr2:232264914 A/C cg13347044 chr2:232276743 NA -0.41 -5.8 -0.3 1.57e-8 Anti-saccade response; CRC cis rs9443645 0.901 rs9343856 chr6:79678211 G/A cg09184832 chr6:79620586 NA -0.51 -9.4 -0.46 9.26e-19 Intelligence (multi-trait analysis); CRC cis rs6952808 1.000 rs59248873 chr7:1888185 A/G cg04267008 chr7:1944627 MAD1L1 -0.69 -10.06 -0.49 6.21e-21 Bipolar disorder and schizophrenia; CRC cis rs7617773 0.779 rs77957078 chr3:48331286 G/C cg11946769 chr3:48343235 NME6 0.72 9.59 0.47 2.28e-19 Coronary artery disease; CRC cis rs7584330 0.737 rs7595979 chr2:238364492 G/T cg14458575 chr2:238380390 NA 0.63 11.84 0.55 3.6e-27 Prostate cancer; CRC cis rs1322512 0.796 rs1744391 chr6:152936761 A/G cg03415253 chr6:152958462 SYNE1 -0.42 -6.57 -0.34 1.99e-10 Tonometry; CRC cis rs1552244 0.882 rs55840655 chr3:10042690 C/T cg00166722 chr3:10149974 C3orf24 0.61 8.0 0.4 2.17e-14 Alzheimer's disease; CRC cis rs17095355 1.000 rs9630102 chr10:111738662 A/T cg00817464 chr10:111662876 XPNPEP1 -0.61 -8.39 -0.42 1.43e-15 Biliary atresia; CRC cis rs2228479 0.850 rs11646766 chr16:89838578 A/T cg19635926 chr16:89946313 TCF25 0.64 5.76 0.3 1.96e-8 Skin colour saturation; CRC cis rs231513 0.822 rs231520 chr17:41956983 T/C cg26893861 chr17:41843967 DUSP3 -0.67 -6.76 -0.35 6.29e-11 Cognitive function; CRC cis rs3204270 0.759 rs8071492 chr17:79682650 G/A cg18367735 chr17:79674897 NA 0.5 5.7 0.3 2.69e-8 Dental caries; CRC cis rs6831352 0.918 rs17218288 chr4:100058030 A/T cg12011299 chr4:100065546 ADH4 -0.49 -9.28 -0.46 2.3e-18 Alcohol dependence; CRC cis rs1862618 0.525 rs2662016 chr5:56269047 A/G cg12311346 chr5:56204834 C5orf35 0.82 11.31 0.53 2.87e-25 Initial pursuit acceleration; CRC cis rs67340775 0.541 rs200973 chr6:27858421 A/G cg02683197 chr6:28174875 NA 0.68 6.86 0.35 3.37e-11 Lung cancer in ever smokers; CRC cis rs6502050 0.835 rs8073351 chr17:80127625 A/G cg22110888 chr17:80059540 CCDC57 0.4 6.43 0.33 4.37e-10 Life satisfaction; CRC trans rs6601327 0.641 rs4840437 chr8:9606264 C/T cg06636001 chr8:8085503 FLJ10661 -0.44 -6.36 -0.33 6.68e-10 Multiple myeloma (hyperdiploidy); CRC cis rs898097 0.585 rs9892342 chr17:80893029 C/T cg03160526 chr17:80928410 B3GNTL1 0.49 7.91 0.4 3.82e-14 Breast cancer; CRC cis rs6500602 0.963 rs7201012 chr16:4480682 C/G cg14951292 chr16:4525986 HMOX2;NMRAL1 0.63 9.15 0.45 6.02e-18 Schizophrenia; CRC cis rs9435341 0.965 rs1335053 chr1:107622823 C/T cg09367891 chr1:107599246 PRMT6 -0.68 -10.12 -0.49 3.88e-21 Facial morphology (factor 21, depth of nasal alae); CRC cis rs9372498 0.536 rs55697388 chr6:118891544 C/T cg01339444 chr6:118972232 C6orf204 0.55 6.23 0.32 1.43e-9 Diastolic blood pressure; CRC cis rs6570726 0.791 rs9373464 chr6:145907167 T/C cg23711669 chr6:146136114 FBXO30 0.68 11.31 0.53 2.81e-25 Lobe attachment (rater-scored or self-reported); CRC cis rs34779708 0.966 rs4934736 chr10:35496868 G/A cg03585969 chr10:35415529 CREM 0.55 7.4 0.38 1.17e-12 Inflammatory bowel disease;Crohn's disease; CRC cis rs7550918 1 rs7550918 chr1:247675559 C/T cg05639522 chr1:247681581 NA -0.5 -8.42 -0.42 1.17e-15 Platelet count; CRC cis rs143626010 1 rs143626010 chr16:28539398 GTGTA/G cg05139728 chr16:28306816 SBK1 -0.36 -5.91 -0.31 8.38e-9 Mosquito bite size; CRC cis rs1950626 0.751 rs12883799 chr14:101396850 A/C cg02351406 chr14:101447389 SNORD114-20;SNORD114-21 0.95 15.97 0.66 6.72e-43 Pelvic organ prolapse (moderate/severe); CRC cis rs889312 0.500 rs832577 chr5:56163787 G/A cg03609598 chr5:56110824 MAP3K1 -0.42 -5.76 -0.3 1.95e-8 Breast cancer;Breast cancer (early onset); CRC cis rs9807841 0.670 rs2569512 chr19:10790162 A/G cg17710535 chr19:10819994 QTRT1 0.43 5.77 0.3 1.87e-8 Inflammatory skin disease; CRC trans rs7395662 0.517 rs11039885 chr11:48647107 A/G cg21153622 chr11:89784906 NA -0.52 -8.68 -0.43 1.91e-16 HDL cholesterol; CRC cis rs208520 0.690 rs12197578 chr6:66725905 C/T cg07460842 chr6:66804631 NA 1.06 14.77 0.63 3.26e-38 Exhaled nitric oxide output; CRC trans rs8002861 0.935 rs9567299 chr13:44456969 G/A cg17145862 chr1:211918768 LPGAT1 0.79 16.07 0.66 2.57e-43 Leprosy; CRC cis rs7552404 0.727 rs2172508 chr1:76320215 A/G cg03433033 chr1:76189801 ACADM 0.69 8.76 0.43 1.09e-16 Blood metabolite levels;Acylcarnitine levels; CRC trans rs7800418 0.723 rs1029557 chr7:26588258 C/T cg14387656 chr2:233470847 EFHD1 0.46 6.37 0.33 6.36e-10 Cognitive function; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg02619135 chr3:51428440 RBM15B 0.5 7.12 0.37 6.71e-12 Response to antipsychotic treatment; CRC cis rs826838 0.935 rs1719855 chr12:39127242 C/T cg13010199 chr12:38710504 ALG10B -0.41 -5.84 -0.31 1.27e-8 Heart rate; CRC cis rs7666738 0.800 rs28427190 chr4:98989106 A/G cg05340658 chr4:99064831 C4orf37 0.61 9.54 0.47 3.21e-19 Colonoscopy-negative controls vs population controls; CRC cis rs76878669 0.606 rs1785639 chr11:66100430 G/A cg18002602 chr11:66138449 SLC29A2 0.28 5.9 0.31 8.88e-9 Educational attainment (years of education); CRC cis rs9323205 0.634 rs61987266 chr14:51734909 C/T cg23942311 chr14:51606299 NA -0.5 -5.92 -0.31 8.17e-9 Cancer; CRC cis rs11971779 0.616 rs6974907 chr7:139068729 G/C cg23387468 chr7:139079360 LUC7L2 0.41 7.04 0.36 1.14e-11 Diisocyanate-induced asthma; CRC cis rs796364 1.000 rs769950 chr2:200730028 A/G cg25936922 chr2:200820526 C2orf60;C2orf47 0.7 7.82 0.4 7.23e-14 Schizophrenia; CRC cis rs10791323 0.576 rs4937840 chr11:133734322 C/G cg06766960 chr11:133703094 NA -0.34 -5.61 -0.3 4.26e-8 Childhood ear infection; CRC cis rs7258465 0.965 rs10408290 chr19:18542701 C/T cg06462663 chr19:18546047 ISYNA1 0.49 7.11 0.36 7.23e-12 Breast cancer; CRC cis rs12898370 0.651 rs11634056 chr15:77539914 G/A cg05673287 chr15:77411982 SGK269 -0.52 -6.73 -0.35 7.67e-11 Risky sexual behaviors (alcohol dependence interaction); CRC cis rs6963495 0.818 rs6961863 chr7:105180953 C/T cg19920283 chr7:105172520 RINT1 0.51 6.04 0.32 4.16e-9 Bipolar disorder (body mass index interaction); CRC cis rs4665809 1.000 rs6750681 chr2:26329677 C/T cg25036284 chr2:26402008 FAM59B -0.46 -6.0 -0.31 5.27e-9 Gut microbiome composition (summer); CRC cis rs4474465 0.831 rs7121299 chr11:78189133 G/T cg27205649 chr11:78285834 NARS2 -0.47 -5.87 -0.31 1.07e-8 Alzheimer's disease (survival time); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg18485485 chr8:91013687 DECR1 0.39 6.11 0.32 2.88e-9 Liver disease severity in Alagille syndrome; CRC cis rs6963495 0.556 rs818474 chr7:105155243 A/T cg02135003 chr7:105160482 PUS7 -0.53 -8.2 -0.41 5.44e-15 Bipolar disorder (body mass index interaction); CRC cis rs10751667 0.666 rs7124480 chr11:971601 G/A ch.11.42038R chr11:967971 AP2A2 0.6 10.37 0.5 5.66e-22 Alzheimer's disease (late onset); CRC cis rs6964587 0.605 rs6956022 chr7:91553199 A/G cg17063962 chr7:91808500 NA -0.6 -9.67 -0.47 1.27e-19 Breast cancer; CRC cis rs8141797 0.748 rs2051199 chr22:24465845 A/G cg20894457 chr22:24584366 SUSD2 -0.64 -6.65 -0.34 1.2e-10 Amyotrophic lateral sclerosis;Coronary artery disease; CRC cis rs71403859 0.730 rs12447672 chr16:71715131 G/A cg08717414 chr16:71523259 ZNF19 -1.01 -8.94 -0.44 2.95e-17 Post bronchodilator FEV1; CRC cis rs9916302 0.904 rs68178216 chr17:37526241 A/C cg07936489 chr17:37558343 FBXL20 0.83 12.75 0.58 1.59e-30 Glomerular filtration rate (creatinine); CRC cis rs116095464 0.558 rs62347683 chr5:230331 C/T cg22857025 chr5:266934 NA -1.19 -16.2 -0.67 7.98e-44 Breast cancer; CRC trans rs11098499 0.955 rs35434465 chr4:120169378 C/G cg25214090 chr10:38739885 LOC399744 0.51 7.7 0.39 1.5700000000000001e-13 Corneal astigmatism; CRC cis rs10504229 0.906 rs6990615 chr8:58182956 G/A cg01721255 chr8:58191610 C8orf71 0.49 6.17 0.32 2e-9 Developmental language disorder (linguistic errors); CRC cis rs7131987 0.650 rs7973786 chr12:29462744 C/T cg09582351 chr12:29534625 ERGIC2 -0.33 -6.97 -0.36 1.7e-11 QT interval; CRC cis rs16870629 1.000 rs16870629 chr5:1015063 C/T cg00278107 chr5:1061253 SLC12A7 -0.75 -10.26 -0.49 1.3e-21 QT interval; CRC cis rs1005277 0.579 rs2474586 chr10:38418882 T/C cg25517755 chr10:38738941 LOC399744 -0.43 -6.25 -0.33 1.27e-9 Extrinsic epigenetic age acceleration; CRC cis rs4319547 0.737 rs11058226 chr12:122938958 A/G cg05707623 chr12:122985044 ZCCHC8 -0.5 -6.87 -0.35 3.28e-11 Body mass index; CRC cis rs7954584 0.545 rs12824593 chr12:122374108 G/A cg21171335 chr12:122356390 WDR66 0.4 6.13 0.32 2.5e-9 Mean corpuscular volume; CRC cis rs1005277 0.579 rs1780139 chr10:38503018 C/T cg00409905 chr10:38381863 ZNF37A -0.62 -10.29 -0.49 1.03e-21 Extrinsic epigenetic age acceleration; CRC cis rs9916302 0.904 rs4794807 chr17:37531718 T/A cg00129232 chr17:37814104 STARD3 0.54 8.03 0.4 1.73e-14 Glomerular filtration rate (creatinine); CRC cis rs4664293 0.967 rs4665103 chr2:160532312 G/A cg08347373 chr2:160653686 CD302 -0.46 -7.29 -0.37 2.26e-12 Monocyte percentage of white cells; CRC cis rs6860806 0.531 rs272887 chr5:131665713 A/G cg02033258 chr5:131593261 PDLIM4 0.38 6.37 0.33 6.32e-10 Breast cancer; CRC cis rs17270561 0.609 rs7770037 chr6:25760591 G/A cg16482183 chr6:26056742 HIST1H1C 0.71 9.0 0.44 1.79e-17 Iron status biomarkers; CRC cis rs2153535 0.580 rs1932285 chr6:8477719 T/G cg07606381 chr6:8435919 SLC35B3 0.68 10.89 0.51 8.87e-24 Motion sickness; CRC cis rs6540559 0.673 rs7550857 chr1:209956542 C/A cg22029157 chr1:209979665 IRF6 0.74 9.47 0.46 5.44e-19 Cleft lip with or without cleft palate; CRC cis rs7762018 0.607 rs79355059 chr6:170062157 T/C cg24289452 chr6:170231220 NA -0.78 -6.96 -0.36 1.86e-11 Thiazide-induced adverse metabolic effects in hypertensive patients; CRC trans rs561341 1.000 rs561341 chr17:30316385 T/G cg27661571 chr11:113659931 NA -0.95 -11.14 -0.52 1.11e-24 Hip circumference adjusted for BMI; CRC cis rs9372498 0.572 rs56082110 chr6:118909480 A/G cg18833306 chr6:118973337 C6orf204 0.43 5.63 0.3 3.92e-8 Diastolic blood pressure; CRC cis rs72781680 0.898 rs72788302 chr2:24107246 C/T cg08917208 chr2:24149416 ATAD2B 1.03 9.75 0.47 6.62e-20 Lymphocyte counts; CRC cis rs651907 0.535 rs35810977 chr3:101531380 G/A cg11279151 chr3:101281821 RG9MTD1 -0.52 -6.94 -0.36 2.06e-11 Colorectal cancer; CRC cis rs9583531 0.600 rs754599 chr13:111354788 C/A cg24331049 chr13:111365604 ING1 0.57 7.9 0.4 4.3e-14 Coronary artery disease; CRC cis rs736408 0.500 rs2878762 chr3:52919002 T/C cg18404041 chr3:52824283 ITIH1 -0.35 -6.62 -0.34 1.49e-10 Bipolar disorder; CRC cis rs853679 0.513 rs9468296 chr6:28113730 A/G cg15845792 chr6:28175446 NA 1.04 13.89 0.61 7.67e-35 Depression; CRC cis rs861020 0.606 rs627459 chr1:210004682 C/G cg09163369 chr1:210001066 C1orf107 0.41 5.77 0.3 1.85e-8 Orofacial clefts; CRC cis rs921968 0.643 rs539451 chr2:219426972 T/C cg02176678 chr2:219576539 TTLL4 0.49 7.93 0.4 3.45e-14 Mean corpuscular hemoglobin concentration; CRC cis rs4588572 0.643 rs1560196 chr5:77701982 G/C cg11446398 chr5:77624930 NA -0.48 -6.71 -0.35 8.28e-11 Triglycerides; CRC cis rs12348691 0.503 rs1867279 chr9:100616041 T/C cg13688889 chr9:100608707 NA -0.47 -6.05 -0.32 3.87e-9 Alopecia areata; CRC cis rs2625529 0.652 rs2929518 chr15:72332748 A/C cg16672083 chr15:72433130 SENP8 0.46 7.02 0.36 1.28e-11 Red blood cell count; CRC cis rs8177179 0.967 rs4994581 chr3:133437563 T/C cg16262614 chr3:133464971 TF 0.44 8.19 0.41 5.85e-15 Iron status biomarkers (transferrin levels); CRC cis rs1707322 1.000 rs11211235 chr1:46440375 G/A cg03146154 chr1:46216737 IPP 0.51 7.06 0.36 1.01e-11 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs6459788 0.934 rs10237947 chr7:157258109 G/T cg06271696 chr7:157225062 NA 0.38 6.49 0.34 3.07e-10 Epstein-Barr virus copy number in lymphoblastoid cell lines; CRC cis rs7923609 1.000 rs4310508 chr10:65138573 A/G cg08743896 chr10:65200160 JMJD1C -0.4 -5.74 -0.3 2.14e-8 Educational attainment;Liver enzyme levels (alkaline phosphatase); CRC cis rs13333054 1.000 rs12232384 chr16:86009760 A/C cg08215318 chr16:86016387 NA -0.77 -11.2 -0.53 6.71e-25 Multiple sclerosis; CRC cis rs12024301 0.557 rs78343928 chr1:183598832 C/T cg11505048 chr1:183622726 RGL1;APOBEC4 0.76 6.93 0.36 2.16e-11 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs9322193 0.923 rs1080670 chr6:149941297 C/G cg05861140 chr6:150128134 PCMT1 -0.36 -5.92 -0.31 8.26e-9 Lung cancer; CRC cis rs2013441 1.000 rs2703801 chr17:20100600 T/C cg13482628 chr17:19912719 NA -0.41 -6.22 -0.32 1.48e-9 Obesity-related traits; CRC cis rs17376456 0.569 rs1349711 chr5:93179032 C/T cg09848695 chr5:92956644 FAM172A;MIR2277 -0.54 -6.26 -0.33 1.21e-9 Diabetic retinopathy; CRC cis rs10256972 0.516 rs12702081 chr7:1141528 T/C cg22907277 chr7:1156413 C7orf50 0.73 11.49 0.54 6.18e-26 Longevity;Endometriosis; CRC cis rs4909189 1.000 rs71547530 chr7:158135503 A/G cg23298862 chr7:158159286 PTPRN2 0.5 7.11 0.37 7.06e-12 Response to amphetamines; CRC cis rs2444240 0.935 rs4936509 chr11:120041444 C/T cg04390734 chr11:120039366 NA 0.28 5.74 0.3 2.14e-8 Corneal curvature; CRC cis rs117623576 1.000 rs117623576 chr10:32387808 C/T cg03047570 chr10:32398778 NA -0.74 -7.29 -0.37 2.25e-12 Anti-saccade response; CRC cis rs4285028 0.948 rs13067270 chr3:121673901 A/C cg20356878 chr3:121714668 ILDR1 -0.48 -6.95 -0.36 1.93e-11 Multiple sclerosis; CRC cis rs9527 1.000 rs4919690 chr10:104616500 C/T cg04362960 chr10:104952993 NT5C2 -0.68 -8.05 -0.41 1.5e-14 Arsenic metabolism; CRC cis rs25422 0.938 rs62422193 chr6:118912285 G/A cg15382696 chr6:118971807 C6orf204 0.59 7.46 0.38 7.96e-13 Renal cell carcinoma; CRC cis rs7618501 0.633 rs7621026 chr3:49975334 A/G cg05623727 chr3:50126028 RBM5 0.45 7.66 0.39 2.06e-13 Intelligence (multi-trait analysis); CRC trans rs587242 1.000 rs2968487 chr1:96887370 C/T cg10631902 chr5:14652156 NA 0.45 6.97 0.36 1.71e-11 Body mass index (joint analysis main effects and physical activity interaction);Body mass index in physically inactive individuals;Body mass index; CRC cis rs12586317 0.547 rs3759548 chr14:35450333 C/T cg16230307 chr14:35515116 FAM177A1 0.87 10.11 0.49 4.22e-21 Psoriasis; CRC cis rs6938 0.618 rs1133323 chr15:75212225 C/T cg14664628 chr15:75095509 CSK -0.6 -8.97 -0.44 2.31e-17 Breast cancer; CRC cis rs10979 1.000 rs9376760 chr6:143886969 C/T cg25407410 chr6:143891975 LOC285740 -0.79 -12.79 -0.58 1.07e-30 Hypospadias; CRC cis rs2976388 0.566 rs4736373 chr8:143792357 G/C cg22687807 chr8:143858763 LYNX1 -0.47 -7.51 -0.38 5.57e-13 Urinary tract infection frequency; CRC cis rs7772486 0.764 rs2247211 chr6:146216379 G/A cg13319975 chr6:146136371 FBXO30 -0.38 -5.84 -0.31 1.29e-8 Lobe attachment (rater-scored or self-reported); CRC cis rs3996993 0.809 rs6458892 chr6:52737138 C/T cg20803780 chr6:52668592 GSTA1 -0.36 -6.83 -0.35 4.19e-11 Hemoglobin concentration; CRC cis rs936229 0.690 rs2445618 chr15:75035256 T/C cg14664628 chr15:75095509 CSK -0.87 -14.52 -0.62 2.97e-37 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); CRC cis rs12692738 0.526 rs355848 chr2:165625277 T/C cg03182029 chr2:165697222 COBLL1 0.5 5.86 0.31 1.11e-8 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);Waist-to-hip ratio adjusted for BMI in non-smokers;Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction);Waist-to-hip ratio adjusted for body mass index; CRC cis rs875971 0.545 rs66594357 chr7:65792784 G/A cg11764359 chr7:65958608 NA 0.46 5.96 0.31 6.49e-9 Aortic root size; CRC cis rs13333054 0.950 rs68143182 chr16:86005838 C/T cg08215318 chr16:86016387 NA 0.75 10.56 0.5 1.25e-22 Multiple sclerosis; CRC cis rs2732480 0.500 rs7297824 chr12:48598650 T/C cg21466736 chr12:48725269 NA -0.53 -8.06 -0.41 1.47e-14 Hemoglobin concentration;Red blood cell count;Hematocrit; CRC cis rs1448094 0.836 rs7484454 chr12:86425576 A/G cg02569458 chr12:86230093 RASSF9 0.39 6.55 0.34 2.2e-10 Major depressive disorder; CRC cis rs951366 0.789 rs823095 chr1:205679239 G/A cg07167872 chr1:205819463 PM20D1 0.74 10.97 0.52 4.39e-24 Menarche (age at onset); CRC cis rs8014204 0.806 rs11159104 chr14:75293374 A/G cg03030879 chr14:75389066 RPS6KL1 -0.51 -8.12 -0.41 9.45e-15 Caffeine consumption; CRC cis rs9527 0.590 rs1046411 chr10:104837816 G/A cg04362960 chr10:104952993 NT5C2 0.59 8.29 0.42 2.87e-15 Arsenic metabolism; CRC cis rs4728302 0.869 rs13221033 chr7:133617487 T/A cg03336402 chr7:133662267 EXOC4 -0.45 -6.5 -0.34 2.92e-10 Intelligence;Intelligence (multi-trait analysis); CRC cis rs875971 0.862 rs2909688 chr7:65841612 C/A cg18876405 chr7:65276391 NA 0.54 8.7 0.43 1.57e-16 Aortic root size; CRC cis rs4919694 1.000 rs4917379 chr10:104752831 A/T cg04362960 chr10:104952993 NT5C2 1.16 10.74 0.51 2.86e-23 Arsenic metabolism; CRC cis rs2303759 0.918 rs1054770 chr19:49878115 G/A cg22133161 chr19:49891603 CCDC155 0.52 7.21 0.37 3.98e-12 Multiple sclerosis; CRC cis rs9486719 0.857 rs1157316 chr6:96869710 G/A cg18709589 chr6:96969512 KIAA0776 0.49 6.24 0.33 1.37e-9 Migraine;Coronary artery disease; CRC cis rs4727963 0.846 rs2402626 chr7:122712358 C/T cg03640110 chr7:122635026 TAS2R16 0.33 5.86 0.31 1.14e-8 Adverse response to chemotherapy (neutropenia/leucopenia) (docetaxel); CRC cis rs6502050 0.805 rs62080003 chr17:80078957 C/T cg25804541 chr17:80189381 SLC16A3 0.32 6.12 0.32 2.72e-9 Life satisfaction; CRC cis rs17095355 1.000 rs11194922 chr10:111695656 G/T cg00817464 chr10:111662876 XPNPEP1 -0.6 -7.9 -0.4 4.13e-14 Biliary atresia; CRC cis rs6754311 0.731 rs3769005 chr2:136603366 C/G cg25344623 chr2:136566232 LCT 0.32 5.78 0.3 1.69e-8 Mosquito bite size; CRC cis rs801193 0.660 rs1016265 chr7:66214567 C/T cg18876405 chr7:65276391 NA 0.51 8.36 0.42 1.82e-15 Aortic root size; CRC cis rs427941 0.632 rs201505 chr7:101760287 T/C cg06246474 chr7:101738831 CUX1 0.45 6.89 0.36 2.79e-11 Plasma omega-3 polyunsaturated fatty acid level (eicosapentaenoic acid); CRC cis rs375066 0.551 rs10408461 chr19:44330772 A/G cg19542119 chr19:44331823 ZNF283 0.41 5.74 0.3 2.1e-8 Breast cancer; CRC cis rs9926296 0.581 rs6500457 chr16:89898764 C/G cg03605463 chr16:89740564 NA 0.39 5.72 0.3 2.39e-8 Vitiligo; CRC cis rs7666738 0.830 rs10470951 chr4:99037051 G/A cg05340658 chr4:99064831 C4orf37 0.61 9.43 0.46 7.65e-19 Colonoscopy-negative controls vs population controls; CRC cis rs875971 0.545 rs73150604 chr7:65945532 T/A cg18876405 chr7:65276391 NA 0.46 6.31 0.33 9.12e-10 Aortic root size; CRC cis rs7312933 0.932 rs10880220 chr12:42383046 A/G cg01256987 chr12:42539512 GXYLT1 -0.39 -5.98 -0.31 5.72e-9 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CRC cis rs9916302 0.784 rs4795361 chr17:37573446 G/A cg03013999 chr17:37608204 MED1 0.47 7.26 0.37 2.88e-12 Glomerular filtration rate (creatinine); CRC cis rs3751196 0.901 rs117932686 chr12:104197523 G/A cg02344784 chr12:104178138 NT5DC3 0.69 7.0 0.36 1.45e-11 Sense of smell; CRC trans rs2727020 0.523 rs7948958 chr11:49506749 G/A cg11707556 chr5:10655725 ANKRD33B 0.48 7.75 0.39 1.15e-13 Coronary artery disease; CRC cis rs1448094 0.511 rs2405616 chr12:86148042 A/G cg19622623 chr12:86230825 RASSF9 0.4 6.15 0.32 2.22e-9 Major depressive disorder; CRC trans rs10506458 0.688 rs73127095 chr12:63418283 T/G cg22491629 chr6:157744540 C6orf35 -0.56 -7.03 -0.36 1.18e-11 Hemostatic factors and hematological phenotypes; CRC cis rs2576037 0.899 rs12955429 chr18:44585484 C/T cg19077165 chr18:44547161 KATNAL2 0.49 7.54 0.38 4.62e-13 Personality dimensions; CRC cis rs13064411 0.696 rs869342 chr3:113226330 C/T cg10517650 chr3:113235015 CCDC52 -0.41 -7.29 -0.37 2.4e-12 Response to simvastatin treatment (PCSK9 protein level change); CRC cis rs7727544 0.507 rs9791170 chr5:131569627 A/G cg04518342 chr5:131593106 PDLIM4 0.51 9.31 0.46 1.85e-18 Blood metabolite levels; CRC cis rs3617 0.573 rs62253582 chr3:52928333 G/A cg11645453 chr3:52864694 ITIH4 -0.42 -8.07 -0.41 1.32e-14 Red blood cell count;Autism spectrum disorder or schizophrenia; CRC cis rs875971 0.964 rs1643388 chr7:65844562 T/C cg18876405 chr7:65276391 NA 0.52 9.04 0.45 1.37e-17 Aortic root size; CRC cis rs274567 0.501 rs272855 chr5:131687175 C/T cg22638593 chr5:131593259 PDLIM4 0.4 6.43 0.33 4.55e-10 Blood metabolite levels; CRC cis rs12188164 0.610 rs57433159 chr5:418725 C/T cg21972741 chr5:435613 AHRR 0.42 5.63 0.3 3.79e-8 Cystic fibrosis severity; CRC cis rs10504229 1.000 rs61998258 chr8:58192284 T/C cg22535103 chr8:58192502 C8orf71 -0.82 -12.27 -0.56 9.63e-29 Developmental language disorder (linguistic errors); CRC trans rs9929218 0.551 rs3785135 chr16:68728976 A/C cg04657470 chr2:198365150 HSPE1;HSPD1 -1.05 -21.5 -0.76 1.18e-64 Colorectal cancer; CRC trans rs6472235 0.837 rs11988360 chr8:66931379 G/A cg07884673 chr3:53033167 SFMBT1 -0.45 -6.03 -0.32 4.47e-9 Myopia (pathological);Plateletcrit; CRC cis rs7786808 0.741 rs4909222 chr7:158228095 C/T cg09998033 chr7:158218633 PTPRN2 0.62 8.98 0.44 2.12e-17 Obesity-related traits; CRC cis rs9826463 0.757 rs73238202 chr3:142205344 C/T cg20824294 chr3:142316082 PLS1 0.41 6.82 0.35 4.41e-11 QRS duration in Tripanosoma cruzi seropositivity; CRC cis rs2811415 0.597 rs2053014 chr3:127760006 A/G cg13719885 chr3:127795394 NA -0.37 -5.67 -0.3 3.19e-8 Lung function (FEV1/FVC); CRC trans rs7027930 0.520 rs10975385 chr9:607178 C/G cg27061366 chr19:13044373 FARSA 0.51 6.25 0.33 1.26e-9 Pulmonary function decline; CRC cis rs1545257 0.537 rs2702088 chr2:24642535 G/C cg06627628 chr2:24431161 ITSN2 -0.47 -6.88 -0.35 3.03e-11 Sjögren's syndrome; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg14178696 chr11:47291038 MADD 0.45 6.28 0.33 1.09e-9 Response to antipsychotic treatment; CRC cis rs3617 0.559 rs11915546 chr3:52866845 A/C cg15147215 chr3:52552868 STAB1 0.53 9.17 0.45 5.29e-18 Red blood cell count;Autism spectrum disorder or schizophrenia; CRC cis rs9435341 0.965 rs56111229 chr1:107566689 T/A cg09367891 chr1:107599246 PRMT6 0.67 10.06 0.49 6.21e-21 Facial morphology (factor 21, depth of nasal alae); CRC cis rs6465657 0.903 rs11767962 chr7:97778576 C/T cg21770322 chr7:97807741 LMTK2 0.87 19.64 0.73 2.25e-57 Prostate cancer (SNP x SNP interaction);Prostate cancer; CRC cis rs7552404 0.731 rs12090849 chr1:76400261 A/G cg10523679 chr1:76189770 ACADM 0.62 7.72 0.39 1.42e-13 Blood metabolite levels;Acylcarnitine levels; CRC cis rs17767392 1.000 rs34748537 chr14:71831683 C/G cg13720639 chr14:72061746 SIPA1L1 -0.54 -6.77 -0.35 5.81e-11 Mitral valve prolapse; CRC cis rs12479064 0.671 rs4851207 chr2:100105775 G/T cg26064155 chr2:99771622 LIPT1;TSGA10 -0.63 -7.43 -0.38 9.56e-13 Chronic sinus infection; CRC cis rs2842992 0.750 rs2758354 chr6:160125854 A/G cg19482086 chr6:160211437 TCP1;MRPL18 0.72 8.87 0.44 4.71e-17 Age-related macular degeneration (geographic atrophy); CRC cis rs1348850 0.914 rs9789582 chr2:178330173 C/G cg02961200 chr2:178257176 LOC100130691;AGPS 0.63 9.25 0.45 2.87e-18 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs2836974 0.583 rs9981884 chr21:40585633 G/A cg11890956 chr21:40555474 PSMG1 0.61 8.88 0.44 4.33e-17 Cognitive function; CRC cis rs28374715 0.662 rs1554445 chr15:41503198 A/C cg18705301 chr15:41695430 NDUFAF1 -0.94 -13.85 -0.61 1.15e-34 Ulcerative colitis; CRC cis rs853679 0.882 rs3757188 chr6:28107357 T/C cg15845792 chr6:28175446 NA 0.8 6.52 0.34 2.67e-10 Depression; CRC trans rs7395662 1.000 rs10838917 chr11:48503127 G/C cg21153622 chr11:89784906 NA -0.48 -7.72 -0.39 1.44e-13 HDL cholesterol; CRC cis rs11792861 0.890 rs3750465 chr9:111900677 T/C cg05043794 chr9:111880884 C9orf5 -0.37 -6.63 -0.34 1.37e-10 Menarche (age at onset); CRC cis rs6087990 0.735 rs1040555 chr20:31380201 A/T cg13636640 chr20:31349939 DNMT3B -0.76 -14.52 -0.62 2.89e-37 Ulcerative colitis; CRC cis rs870825 0.616 rs2141258 chr4:185609576 A/C cg04058563 chr4:185651563 MLF1IP -0.57 -6.45 -0.33 4.1e-10 Blood protein levels; CRC cis rs13108904 0.935 rs2199956 chr4:1248919 A/G cg16405210 chr4:1374714 KIAA1530 -0.45 -6.42 -0.33 4.89e-10 Obesity-related traits; CRC cis rs7615952 0.641 rs61048217 chr3:125807905 G/T cg04553112 chr3:125709451 NA -0.53 -6.09 -0.32 3.2e-9 Blood pressure (smoking interaction); CRC trans rs11098499 0.865 rs28845498 chr4:120405186 G/A cg25214090 chr10:38739885 LOC399744 0.65 10.37 0.5 5.64e-22 Corneal astigmatism; CRC cis rs3849570 1.000 rs9842330 chr3:81814688 G/A cg07356753 chr3:81810745 GBE1 -0.73 -11.05 -0.52 2.37e-24 Waist circumference;Body mass index; CRC cis rs709400 0.832 rs10145755 chr14:104121984 C/T cg24130564 chr14:104152367 KLC1 -0.45 -6.77 -0.35 5.8e-11 Body mass index; CRC cis rs6951245 0.554 rs10246354 chr7:1132456 C/T cg22907277 chr7:1156413 C7orf50 0.88 11.33 0.53 2.35e-25 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs7666738 0.830 rs28867087 chr4:98880349 T/A cg05340658 chr4:99064831 C4orf37 0.59 8.98 0.44 2.15e-17 Colonoscopy-negative controls vs population controls; CRC cis rs3849570 0.925 rs6765917 chr3:81891116 C/T cg07356753 chr3:81810745 GBE1 -0.66 -9.67 -0.47 1.28e-19 Waist circumference;Body mass index; CRC cis rs11696845 0.626 rs1111032 chr20:43378770 A/G cg25301532 chr20:43378953 KCNK15 0.41 7.1 0.36 7.96e-12 Obesity-related traits; CRC cis rs6586163 0.843 rs1926199 chr10:90746660 G/T cg13456138 chr10:90753195 FAS -0.44 -6.61 -0.34 1.54e-10 Chronic lymphocytic leukemia; CRC cis rs1843834 0.539 rs6749402 chr2:225443901 T/G cg22509189 chr2:225307070 NA -0.4 -5.94 -0.31 7.33e-9 IgE levels in asthmatics (D.p. specific); CRC cis rs910187 0.537 rs2154035 chr20:45760083 T/G cg27589058 chr20:45804311 EYA2 -0.35 -6.28 -0.33 1.04e-9 Migraine; CRC cis rs798554 0.797 rs798491 chr7:2800521 A/G cg13628971 chr7:2884303 GNA12 0.55 7.21 0.37 3.82e-12 Height; CRC cis rs6545883 0.931 rs11125885 chr2:61755728 G/C cg15711740 chr2:61764176 XPO1 -0.53 -7.37 -0.38 1.37e-12 Tuberculosis; CRC trans rs9858542 0.953 rs4625 chr3:49572140 A/G cg21582582 chr3:182698605 DCUN1D1 -0.54 -6.84 -0.35 3.93e-11 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs7149337 0.869 rs10137445 chr14:51694416 G/A cg23942311 chr14:51606299 NA 0.75 13.72 0.6 3.41e-34 Cancer; CRC cis rs758324 0.947 rs600661 chr5:131290894 T/C cg06307176 chr5:131281290 NA -0.39 -5.65 -0.3 3.39e-8 Alzheimer's disease in APOE e4- carriers; CRC cis rs1552244 1.000 rs68045038 chr3:10151828 A/G cg13047869 chr3:10149882 C3orf24 0.57 7.76 0.39 1.08e-13 Alzheimer's disease; CRC cis rs58688157 0.626 rs7941198 chr11:571681 A/G cg16486109 chr11:613632 IRF7 0.59 10.47 0.5 2.42e-22 Systemic lupus erythematosus; CRC cis rs6502050 0.835 rs12450189 chr17:80095128 A/C cg02741985 chr17:80059408 CCDC57 0.43 7.15 0.37 5.66e-12 Life satisfaction; CRC trans rs7613875 0.641 rs6793528 chr3:50100188 C/A cg21659725 chr3:3221576 CRBN -0.46 -6.77 -0.35 6.01e-11 Body mass index; CRC cis rs72945132 0.882 rs6592554 chr11:70226040 G/A cg00319359 chr11:70116639 PPFIA1 0.55 6.0 0.31 5.09e-9 Coronary artery disease; CRC cis rs8018967 1.000 rs8018967 chr14:73976934 A/G cg19682024 chr14:74008259 HEATR4;ACOT1 -0.49 -7.26 -0.37 2.89e-12 Blood metabolite ratios; CRC cis rs6952808 1.000 rs6957894 chr7:1887362 G/A cg20295408 chr7:1910781 MAD1L1 -0.44 -6.35 -0.33 7.29e-10 Bipolar disorder and schizophrenia; CRC trans rs629535 0.821 rs650267 chr8:70029160 C/T cg21567404 chr3:27674614 NA 0.95 15.98 0.66 5.8e-43 Dupuytren's disease; CRC cis rs736408 0.812 rs2270197 chr3:52824095 T/G cg11645453 chr3:52864694 ITIH4 0.4 6.56 0.34 2.05e-10 Bipolar disorder; CRC cis rs11190604 1.000 rs3750719 chr10:102248950 C/G cg16342193 chr10:102329863 NA -0.37 -5.95 -0.31 6.76e-9 Palmitoleic acid (16:1n-7) levels; CRC cis rs2243480 1.000 rs1873494 chr7:65649899 T/C cg12463550 chr7:65579703 CRCP -0.71 -6.52 -0.34 2.61e-10 Diabetic kidney disease; CRC cis rs7666738 0.830 rs6854594 chr4:99065312 A/T cg17366294 chr4:99064904 C4orf37 0.43 7.2 0.37 4.02e-12 Colonoscopy-negative controls vs population controls; CRC cis rs6502050 0.835 rs4789738 chr17:80123053 G/A cg19223190 chr17:80058835 NA 0.39 6.23 0.32 1.43e-9 Life satisfaction; CRC cis rs10924970 0.967 rs3845566 chr1:235449757 T/A cg26050004 chr1:235667680 B3GALNT2 0.4 5.97 0.31 6.04e-9 Asthma; CRC cis rs73206853 0.841 rs57726856 chr12:110961123 T/C cg12870014 chr12:110450643 ANKRD13A 0.71 7.68 0.39 1.86e-13 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC cis rs9457247 1.000 rs2757042 chr6:167371234 A/T cg23791538 chr6:167370224 RNASET2 0.38 5.91 0.31 8.63e-9 Crohn's disease; CRC cis rs2019137 1.000 rs2019137 chr2:113973632 G/A cg11763394 chr2:113992921 PAX8;LOC440839;LOC654433 -0.5 -7.18 -0.37 4.68e-12 Lymphocyte counts; CRC cis rs8060686 0.641 rs8059305 chr16:68036666 A/C cg09835421 chr16:68378352 PRMT7 -0.49 -5.86 -0.31 1.09e-8 HDL cholesterol;Metabolic syndrome; CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg09372928 chr1:6845395 CAMTA1 0.42 6.71 0.35 8.64e-11 Obesity-related traits; CRC cis rs9311474 0.569 rs7614981 chr3:52566914 G/T cg13284614 chr3:52569169 NT5DC2;LOC440957 0.37 6.19 0.32 1.83e-9 Electroencephalogram traits; CRC cis rs12142240 0.698 rs28578741 chr1:46825176 T/C cg00530320 chr1:46809349 NSUN4 0.59 8.03 0.41 1.69e-14 Menopause (age at onset); CRC cis rs4862750 0.832 rs9995958 chr4:187901764 G/A cg27532560 chr4:187881888 NA -0.57 -10.58 -0.5 1.04e-22 Lobe attachment (rater-scored or self-reported); CRC cis rs897984 0.806 rs8050588 chr16:30937799 G/A cg00531865 chr16:30841666 NA -0.49 -7.07 -0.36 9.24e-12 Dementia with Lewy bodies; CRC trans rs11146838 1 rs11146838 chr10:39149977 A/T cg17830980 chr10:43048298 ZNF37B -0.51 -8.22 -0.41 4.9e-15 Breast cancer; CRC cis rs12477438 0.834 rs1563107 chr2:99701276 A/G cg26064155 chr2:99771622 LIPT1;TSGA10 0.63 8.89 0.44 4.11e-17 Chronic sinus infection; CRC cis rs28386778 0.863 rs3826341 chr17:61819222 C/A cg11494091 chr17:61959527 GH2 0.58 9.87 0.48 2.75e-20 Prudent dietary pattern; CRC cis rs870825 0.550 rs57301026 chr4:185646505 C/G cg04058563 chr4:185651563 MLF1IP 0.72 9.3 0.46 2.04e-18 Blood protein levels; CRC cis rs826838 1.000 rs1393537 chr12:38920961 C/T cg13010199 chr12:38710504 ALG10B 0.46 6.01 0.31 4.96e-9 Heart rate; CRC cis rs7647973 1.000 rs9871024 chr3:49554241 T/C cg20833759 chr3:49053208 WDR6;DALRD3 -0.54 -8.04 -0.41 1.69e-14 Menarche (age at onset); CRC cis rs2976388 0.590 rs11785290 chr8:143814849 A/G cg05569086 chr8:143859399 LYNX1 -0.4 -6.53 -0.34 2.51e-10 Urinary tract infection frequency; CRC cis rs7618915 0.547 rs11130313 chr3:52676190 A/C cg18099408 chr3:52552593 STAB1 -0.43 -7.08 -0.36 8.86e-12 Bipolar disorder; CRC cis rs4862750 0.872 rs6830426 chr4:187897270 T/A cg27532560 chr4:187881888 NA -0.56 -10.23 -0.49 1.63e-21 Lobe attachment (rater-scored or self-reported); CRC cis rs11190604 1.000 rs2295773 chr10:102265815 A/G cg16342193 chr10:102329863 NA -0.36 -6.05 -0.32 3.85e-9 Palmitoleic acid (16:1n-7) levels; CRC cis rs7246657 0.943 rs10420722 chr19:37973774 C/G cg23950597 chr19:37808831 NA -0.54 -6.48 -0.34 3.38e-10 Coronary artery calcification; CRC cis rs9807989 0.524 rs2110662 chr2:103020139 A/T cg03938978 chr2:103052716 IL18RAP 0.59 10.17 0.49 2.54e-21 Asthma; CRC cis rs9649213 0.555 rs67132564 chr7:98014900 T/A cg24562669 chr7:97807699 LMTK2 0.44 7.25 0.37 3.02e-12 Prostate cancer (SNP x SNP interaction); CRC cis rs2228479 0.867 rs35542367 chr16:89965825 G/C cg06656553 chr16:89960601 TCF25 -0.61 -5.66 -0.3 3.27e-8 Skin colour saturation; CRC cis rs11690935 0.921 rs7594711 chr2:172895637 T/G cg13550731 chr2:172543902 DYNC1I2 -1.02 -15.06 -0.64 2.38e-39 Schizophrenia; CRC cis rs4474465 0.915 rs12794810 chr11:78212743 T/C cg27205649 chr11:78285834 NARS2 0.49 6.05 0.32 3.86e-9 Alzheimer's disease (survival time); CRC cis rs1568889 0.877 rs57202579 chr11:28221677 T/C cg06544937 chr11:28130018 METT5D1;KIF18A 0.79 11.3 0.53 2.99e-25 Bipolar disorder; CRC cis rs16858210 0.874 rs35717944 chr3:183607361 C/A cg25686905 chr3:183603175 PARL -0.49 -6.71 -0.35 8.39e-11 Menopause (age at onset); CRC cis rs9487051 0.714 rs7774390 chr6:109602461 C/G cg12927641 chr6:109611667 NA 0.37 6.48 0.34 3.39e-10 Reticulocyte fraction of red cells; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg14471455 chr9:80332956 NA 0.4 5.98 0.31 5.87e-9 Myopia (pathological); CRC trans rs4689592 0.503 rs59640165 chr4:7051661 G/A cg07817883 chr1:32538562 TMEM39B 0.68 7.46 0.38 7.66e-13 Monocyte percentage of white cells; CRC cis rs6540559 1.000 rs6540559 chr1:209982025 G/A cg22029157 chr1:209979665 IRF6 0.63 9.58 0.47 2.53e-19 Cleft lip with or without cleft palate; CRC cis rs10982256 0.774 rs1535960 chr9:117251352 C/T cg13636371 chr9:117264095 DFNB31 0.34 6.62 0.34 1.47e-10 Bipolar disorder; CRC cis rs2839186 0.632 rs17176110 chr21:47706535 C/A cg00612595 chr21:47717864 NA -0.37 -6.18 -0.32 1.89e-9 Testicular germ cell tumor; CRC cis rs11098499 0.615 rs59867181 chr4:120556467 C/T cg24375607 chr4:120327624 NA -0.4 -6.32 -0.33 8.41e-10 Corneal astigmatism; CRC cis rs1552244 0.882 rs17050699 chr3:10037167 G/A cg10729496 chr3:10149963 C3orf24 0.49 6.34 0.33 7.69e-10 Alzheimer's disease; CRC cis rs6543140 0.964 rs1035126 chr2:103019981 C/T cg03938978 chr2:103052716 IL18RAP 0.45 7.06 0.36 9.71e-12 Blood protein levels; CRC cis rs9457247 0.967 rs86755 chr6:167403108 T/C cg23791538 chr6:167370224 RNASET2 -0.38 -5.94 -0.31 7.32e-9 Crohn's disease; CRC cis rs11229555 0.645 rs12289985 chr11:58185436 C/G cg15696309 chr11:58395628 NA -0.81 -10.31 -0.49 8.83e-22 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; CRC cis rs172166 0.516 rs2622322 chr6:28117443 C/G cg25164649 chr6:28176230 NA 0.47 6.88 0.35 2.98e-11 Cardiac Troponin-T levels; CRC trans rs4918814 0.955 rs7090377 chr10:115107258 A/G cg25339052 chr2:196399403 NA 0.38 6.1 0.32 2.91e-9 Neuroticism (multi-trait analysis); CRC cis rs12701220 0.901 rs12701710 chr7:1090396 A/G cg00990874 chr7:1149470 C7orf50 0.45 5.73 0.3 2.31e-8 Bronchopulmonary dysplasia; CRC cis rs875971 0.522 rs4718285 chr7:65292005 A/G cg05627663 chr7:65219948 SNORA22;CCT6P1 0.48 7.27 0.37 2.6e-12 Aortic root size; CRC cis rs2239547 0.657 rs2072391 chr3:52862200 C/T cg15147215 chr3:52552868 STAB1 -0.43 -6.09 -0.32 3.12e-9 Schizophrenia; CRC cis rs12681287 0.640 rs13256765 chr8:87457833 C/T cg27223183 chr8:87520930 FAM82B -0.52 -7.44 -0.38 8.7e-13 Caudate activity during reward; CRC cis rs1552244 0.882 rs13075842 chr3:10055813 A/C cg08888203 chr3:10149979 C3orf24 0.63 8.2 0.41 5.64e-15 Alzheimer's disease; CRC trans rs7395662 0.525 rs4882060 chr11:48441874 G/C cg21153622 chr11:89784906 NA -0.49 -8.17 -0.41 6.55e-15 HDL cholesterol; CRC cis rs12541635 0.966 rs7812766 chr8:107057033 G/A cg10147462 chr8:107024639 NA 0.47 7.82 0.4 7.24e-14 Age of smoking initiation; CRC cis rs4908768 0.501 rs11121201 chr1:8632791 A/T cg20416874 chr1:8611966 RERE -0.45 -6.35 -0.33 7.29e-10 Neuroticism (multi-trait analysis);Subjective well-being (multi-trait analysis); CRC cis rs3858526 0.514 rs4595572 chr11:5864045 T/G cg02574844 chr11:5959923 NA -0.58 -9.7 -0.47 9.59e-20 DNA methylation (variation); CRC cis rs2836754 1.000 rs11701117 chr21:40292512 C/T cg20434300 chr21:40194735 ETS2 -0.34 -5.87 -0.31 1.04e-8 Crohn's disease;Body mass index; CRC cis rs9517320 1.000 rs7994160 chr13:99132749 C/A cg07423050 chr13:99094983 FARP1 0.38 5.93 0.31 7.56e-9 Longevity; CRC trans rs7613875 0.620 rs17657688 chr3:50033228 C/T cg21665057 chr3:196295764 WDR53;FBXO45 -0.48 -7.18 -0.37 4.65e-12 Body mass index; CRC cis rs853679 0.517 rs1340004 chr6:28103691 C/T cg12963246 chr6:28129442 ZNF389 0.48 5.61 0.3 4.24e-8 Depression; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg03900353 chr1:212732456 NA 0.53 7.03 0.36 1.21e-11 Thyroid stimulating hormone; CRC cis rs9381040 0.748 rs9357348 chr6:41154232 A/G cg03644281 chr6:41068752 NFYA;LOC221442 -0.4 -5.83 -0.31 1.35e-8 Alzheimer's disease (late onset); CRC cis rs763014 0.932 rs35067229 chr16:649638 T/C cg00802000 chr16:706648 WDR90 -0.44 -6.46 -0.34 3.68e-10 Height; CRC cis rs7909074 0.966 rs4245614 chr10:45397007 C/T cg04218760 chr10:45406644 TMEM72 -0.34 -9.3 -0.46 1.99e-18 Mean corpuscular volume; CRC cis rs7647973 1.000 rs1464569 chr3:49460350 A/G cg07690219 chr3:49449608 TCTA;RHOA -0.51 -6.0 -0.31 5.16e-9 Menarche (age at onset); CRC cis rs7493 0.806 rs17876090 chr7:95053404 A/T cg04155289 chr7:94953770 PON1 -0.65 -7.85 -0.4 6.09e-14 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs10504229 0.817 rs35207430 chr8:58167614 G/A cg02725872 chr8:58115012 NA -0.4 -7.16 -0.37 5.44e-12 Developmental language disorder (linguistic errors); CRC cis rs28386778 0.897 rs894406 chr17:61901657 A/G cg23090583 chr17:61904693 PSMC5;FTSJ3 1.05 20.68 0.75 1.83e-61 Prudent dietary pattern; CRC cis rs2180341 1.000 rs2144743 chr6:127633810 A/T cg24812749 chr6:127587940 RNF146 0.94 13.69 0.6 4.55e-34 Breast cancer; CRC cis rs13191362 1.000 rs73035021 chr6:163000716 C/A cg06582575 chr6:163149167 PACRG;PARK2 0.77 10.7 0.51 3.98e-23 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs2688608 0.592 rs10762560 chr10:75495405 T/G cg16540259 chr10:75572220 NDST2 0.38 5.98 0.31 5.77e-9 Inflammatory bowel disease; CRC cis rs929354 0.772 rs933344 chr7:157011265 A/T cg16102536 chr7:156981717 UBE3C 0.4 6.77 0.35 5.75e-11 Body mass index; CRC cis rs9649213 0.537 rs6971825 chr7:97979548 C/T cg00277769 chr7:97922759 BAIAP2L1 -0.59 -10.3 -0.49 9.77e-22 Prostate cancer (SNP x SNP interaction); CRC trans rs7011507 1.000 rs13270488 chr8:49196047 T/A cg04544946 chr8:978226 NA 0.44 6.09 0.32 3.18e-9 Inflammatory bowel disease;Ulcerative colitis; CRC cis rs826838 0.872 rs826878 chr12:39088837 A/T cg26384229 chr12:38710491 ALG10B -0.57 -8.44 -0.42 9.94e-16 Heart rate; CRC cis rs9914988 0.619 rs9898529 chr17:27318861 A/T cg16670446 chr17:27188758 MIR451;MIR144 0.46 6.31 0.33 9.19e-10 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs6681460 0.932 rs4655640 chr1:67089220 T/C cg02459107 chr1:67143332 SGIP1 0.43 7.14 0.37 6.19e-12 Presence of antiphospholipid antibodies; CRC cis rs7487075 0.820 rs6582625 chr12:46698317 C/T cg22049899 chr12:47219821 SLC38A4 0.33 5.99 0.31 5.61e-9 Itch intensity from mosquito bite; CRC cis rs9837602 1.000 rs1688766 chr3:99647850 G/A cg07805332 chr3:99536008 MIR548G;C3orf26 -0.47 -6.35 -0.33 6.99e-10 Breast cancer; CRC cis rs9837602 1.000 rs35521705 chr3:99716690 C/T cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G 0.48 5.75 0.3 2.09e-8 Breast cancer; CRC cis rs2249625 0.564 rs2496496 chr6:72884053 A/G cg18830697 chr6:72922368 RIMS1 -0.39 -7.9 -0.4 4.11e-14 Acute urticaria and angioedema (non-steroidal anti-inflammatory drug-induced); CRC cis rs35306767 0.669 rs2101051 chr10:1158791 G/T cg26597838 chr10:835615 NA 0.73 8.05 0.41 1.48e-14 Eosinophil percentage of granulocytes; CRC cis rs490234 0.932 rs577026 chr9:128341023 C/T cg14078157 chr9:128172775 NA -0.37 -6.23 -0.32 1.43e-9 Mean arterial pressure; CRC cis rs2290405 1.000 rs2290405 chr4:946974 A/G cg16931447 chr4:875861 GAK 0.35 5.69 0.3 2.83e-8 Systemic sclerosis; CRC trans rs10838798 0.523 rs4752917 chr11:48241639 A/G cg03929089 chr4:120376271 NA -0.46 -6.57 -0.34 1.95e-10 Height; CRC cis rs10450586 0.932 rs10082678 chr11:27320448 C/T cg10370305 chr11:27303972 NA -0.36 -5.9 -0.31 9.02e-9 Total body bone mineral density; CRC cis rs10504229 0.815 rs72650879 chr8:58164648 A/G cg02290350 chr8:58132656 NA -0.5 -6.19 -0.32 1.75e-9 Developmental language disorder (linguistic errors); CRC cis rs1448094 0.511 rs10746353 chr12:86150146 A/T cg06740227 chr12:86229804 RASSF9 -0.37 -5.64 -0.3 3.71e-8 Major depressive disorder; CRC cis rs12586317 0.620 rs2295104 chr14:35579927 A/G cg05294307 chr14:35346193 BAZ1A 0.63 7.13 0.37 6.4e-12 Psoriasis; CRC trans rs2303319 0.504 rs1449641 chr2:162619567 T/C cg27342122 chr8:133787442 PHF20L1 -0.72 -6.09 -0.32 3.2e-9 Cognitive function; CRC cis rs6963495 0.769 rs11556986 chr7:105177041 A/T cg19920283 chr7:105172520 RINT1 0.51 5.9 0.31 9e-9 Bipolar disorder (body mass index interaction); CRC cis rs17023223 0.537 rs55836852 chr1:119725401 G/A cg05756136 chr1:119680316 WARS2 -0.52 -7.14 -0.37 6e-12 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for BMI in active individuals; CRC cis rs4665809 1.000 rs7573118 chr2:26308086 A/G cg04944784 chr2:26401820 FAM59B -0.6 -7.77 -0.39 1.01e-13 Gut microbiome composition (summer); CRC cis rs4819052 0.851 rs28501512 chr21:46676702 C/T cg02159808 chr21:46707872 POFUT2;LOC642852 0.53 6.94 0.36 2.15e-11 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs9486719 1.000 rs2092096 chr6:96870919 A/G cg06623918 chr6:96969491 KIAA0776 0.77 9.26 0.45 2.68e-18 Migraine;Coronary artery disease; CRC cis rs6546550 0.713 rs6718517 chr2:70018462 T/C cg02498382 chr2:70120550 SNRNP27 -0.42 -6.89 -0.35 2.9e-11 Prevalent atrial fibrillation; CRC cis rs9875589 0.509 rs11718142 chr3:14018793 G/T cg14375111 chr3:14165186 TMEM43;CHCHD4 0.4 6.22 0.32 1.53e-9 Ovarian reserve; CRC cis rs3733585 0.781 rs4292328 chr4:9970962 C/T cg00071950 chr4:10020882 SLC2A9 -0.65 -12.04 -0.55 6.65e-28 Cleft plate (environmental tobacco smoke interaction); CRC cis rs1707322 1.000 rs9793167 chr1:46446800 G/A cg06784218 chr1:46089804 CCDC17 0.51 8.96 0.44 2.39e-17 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs12701220 0.655 rs34696066 chr7:1140919 C/T cg26769984 chr7:1090371 C7orf50 0.51 6.91 0.36 2.59e-11 Bronchopulmonary dysplasia; CRC cis rs9322193 0.962 rs6914319 chr6:150127440 G/A cg05861140 chr6:150128134 PCMT1 -0.43 -7.05 -0.36 1.03e-11 Lung cancer; CRC cis rs9911578 0.967 rs11656413 chr17:57082013 A/C cg12560992 chr17:57184187 TRIM37 -0.94 -17.93 -0.7 1.24e-50 Intelligence (multi-trait analysis); CRC cis rs4711336 0.664 rs4713663 chr6:33674197 G/A cg14003231 chr6:33640908 ITPR3 0.48 7.69 0.39 1.67e-13 Height; CRC trans rs3780486 1.000 rs3780486 chr9:33139453 C/T cg04842962 chr6:43655489 MRPS18A 1.0 15.53 0.65 3.62e-41 IgG glycosylation; CRC cis rs877282 1.000 rs12763443 chr10:771941 G/A cg06581033 chr10:766294 NA -0.5 -5.73 -0.3 2.28e-8 Uric acid levels; CRC cis rs7312933 0.670 rs10880258 chr12:42547531 C/T cg11827402 chr12:42719852 PPHLN1;ZCRB1 0.64 8.82 0.44 6.95e-17 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CRC cis rs847649 0.699 rs10241865 chr7:102527517 G/A cg18108683 chr7:102477205 FBXL13 -0.63 -10.87 -0.51 9.92e-24 Morning vs. evening chronotype; CRC cis rs9837602 0.938 rs9815439 chr3:99785206 G/C cg07805332 chr3:99536008 MIR548G;C3orf26 -0.5 -6.79 -0.35 5.26e-11 Breast cancer; CRC trans rs7395662 1.000 rs11039854 chr11:48607688 G/A cg21153622 chr11:89784906 NA -0.45 -7.21 -0.37 3.98e-12 HDL cholesterol; CRC cis rs4964805 1.000 rs11111791 chr12:104193271 C/G cg02344784 chr12:104178138 NT5DC3 0.5 7.05 0.36 1.03e-11 Attention deficit hyperactivity disorder; CRC cis rs6582630 0.598 rs12823134 chr12:38514347 T/A cg13010199 chr12:38710504 ALG10B -0.42 -5.93 -0.31 7.61e-9 Drug-induced liver injury (flucloxacillin); CRC cis rs6912958 0.781 rs4464759 chr6:88282621 A/C cg12350822 chr6:88032061 C6orf162;GJB7 -0.34 -6.37 -0.33 6.44e-10 Monocyte percentage of white cells; CRC cis rs4969178 0.600 rs4969183 chr17:76393372 A/G cg05887092 chr17:76393375 PGS1 0.63 12.66 0.57 3.46e-30 HDL cholesterol levels; CRC cis rs10504229 0.683 rs17802743 chr8:58105897 C/T cg20607798 chr8:58055168 NA 0.52 5.93 0.31 7.73e-9 Developmental language disorder (linguistic errors); CRC cis rs926938 0.527 rs360670 chr1:115482386 G/A cg12756093 chr1:115239321 AMPD1 0.48 7.02 0.36 1.3e-11 Autism; CRC cis rs6694672 1.000 rs1170880 chr1:196947314 C/T cg13682187 chr1:196946512 CFHR5 0.51 7.98 0.4 2.41e-14 Asthma; CRC cis rs1891275 0.509 rs34190234 chr10:93443074 A/C cg07889827 chr10:93443413 NA -0.37 -6.25 -0.33 1.25e-9 Intelligence (multi-trait analysis); CRC cis rs10504229 0.683 rs58883273 chr8:58138275 A/G cg22535103 chr8:58192502 C8orf71 -0.7 -9.34 -0.46 1.47e-18 Developmental language disorder (linguistic errors); CRC cis rs10752881 0.967 rs8179284 chr1:182974707 C/T ch.1.3577855R chr1:183094577 LAMC1 0.87 15.17 0.64 8.98e-40 Colorectal cancer; CRC cis rs898097 0.756 rs11655103 chr17:80813467 T/C cg15369054 chr17:80825471 TBCD 0.53 8.86 0.44 5.25e-17 Breast cancer; CRC cis rs17345786 1.000 rs58907984 chr3:101305170 T/G cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.57 6.72 0.35 8.13e-11 Colonoscopy-negative controls vs population controls; CRC cis rs853679 0.517 rs9393894 chr6:28112562 A/G cg15786705 chr6:28176104 NA 0.78 9.83 0.48 3.57e-20 Depression; CRC cis rs2249625 0.523 rs2496554 chr6:72855840 A/T cg18830697 chr6:72922368 RIMS1 -0.31 -6.17 -0.32 1.97e-9 Acute urticaria and angioedema (non-steroidal anti-inflammatory drug-induced); CRC trans rs1005277 0.505 rs7917943 chr10:38195811 T/A cg27523141 chr10:43048294 ZNF37B -0.45 -6.57 -0.34 2.02e-10 Extrinsic epigenetic age acceleration; CRC cis rs6880778 0.505 rs6891952 chr5:40400885 C/T cg09067459 chr5:40385259 NA 0.45 7.75 0.39 1.13e-13 Inflammatory bowel disease; CRC trans rs2303319 0.504 rs62189041 chr2:162599506 T/C cg03774468 chr3:140950104 ACPL2 -0.65 -6.07 -0.32 3.61e-9 Cognitive function; CRC cis rs875971 0.893 rs62465470 chr7:65601218 T/C cg12463550 chr7:65579703 CRCP -0.53 -7.4 -0.38 1.13e-12 Aortic root size; CRC cis rs2228479 0.850 rs11639788 chr16:89807543 G/A cg06656553 chr16:89960601 TCF25 -0.68 -5.71 -0.3 2.55e-8 Skin colour saturation; CRC cis rs6940638 0.688 rs7744759 chr6:27119826 G/A cg12292205 chr6:26970375 C6orf41 -0.47 -6.45 -0.34 3.94e-10 Intelligence (multi-trait analysis); CRC cis rs10504229 0.683 rs7843919 chr8:58130792 T/C cg21724239 chr8:58056113 NA 0.49 6.81 0.35 4.75e-11 Developmental language disorder (linguistic errors); CRC cis rs7107174 1.000 rs7101429 chr11:77992967 A/G cg02023728 chr11:77925099 USP35 0.5 7.16 0.37 5.15e-12 Testicular germ cell tumor; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg14963534 chr19:17420130 DDA1 0.4 6.54 0.34 2.37e-10 Liver disease severity in Alagille syndrome; CRC cis rs597539 0.652 rs673821 chr11:68678718 G/T cg06028808 chr11:68637592 NA 0.4 6.37 0.33 6.44e-10 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs6570726 0.846 rs1935616 chr6:145943512 C/T cg13319975 chr6:146136371 FBXO30 -0.43 -6.42 -0.33 4.84e-10 Lobe attachment (rater-scored or self-reported); CRC cis rs9303401 0.625 rs34963822 chr17:56988424 C/A cg02118635 chr17:56770003 RAD51C;TEX14 0.8 10.21 0.49 1.93e-21 Cognitive test performance; CRC cis rs9858542 0.953 rs9837341 chr3:49664767 A/G cg00383909 chr3:49044727 WDR6 0.48 5.92 0.31 7.98e-9 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs908922 0.676 rs1538083 chr1:152517116 A/G cg23254163 chr1:152506842 NA 0.44 8.58 0.43 3.71e-16 Hair morphology; CRC cis rs56775891 0.959 rs11663602 chr18:77578191 G/T cg24058013 chr18:77568902 NA -0.46 -7.86 -0.4 5.48e-14 Schizophrenia; CRC cis rs10540 0.730 rs34690033 chr11:492677 G/C cg08200582 chr11:442649 ANO9 -0.73 -7.6 -0.39 3.19e-13 Body mass index; CRC trans rs208520 0.690 rs1351867 chr6:66760995 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 1.04 14.51 0.62 3.17e-37 Exhaled nitric oxide output; CRC cis rs6570726 0.791 rs374478 chr6:145840022 C/T cg05347473 chr6:146136440 FBXO30 0.4 6.23 0.32 1.45e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs728616 0.867 rs61860034 chr10:81931848 C/T cg05935833 chr10:81318306 SFTPA2 -0.75 -8.24 -0.41 4.02e-15 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs4654899 0.865 rs6671056 chr1:21488610 G/A cg02927042 chr1:21476669 EIF4G3 -0.51 -7.98 -0.4 2.4e-14 Superior frontal gyrus grey matter volume; CRC cis rs9462846 0.881 rs9296402 chr6:42875650 G/A cg10862848 chr6:42927986 GNMT -0.28 -5.63 -0.3 3.9e-8 Blood protein levels; CRC cis rs910316 0.763 rs175036 chr14:75464295 C/T cg08847533 chr14:75593920 NEK9 -0.85 -14.67 -0.63 7.63e-38 Height; CRC cis rs2742417 1.000 rs2673025 chr3:45760483 A/G cg04837898 chr3:45731254 SACM1L -0.34 -5.7 -0.3 2.71e-8 Response to anti-depressant treatment in major depressive disorder; CRC cis rs1799949 0.965 rs7212284 chr17:41205941 A/G cg05368731 chr17:41323189 NBR1 0.63 9.68 0.47 1.11e-19 Menopause (age at onset); CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg00885901 chr1:10459695 PGD 0.5 6.69 0.35 9.35e-11 Thyroid stimulating hormone; CRC cis rs4713118 0.587 rs61471148 chr6:28037032 T/A cg03623178 chr6:28175578 NA 0.87 11.46 0.53 8.46e-26 Parkinson's disease; CRC cis rs1018836 0.828 rs7014967 chr8:91557843 G/T cg16814680 chr8:91681699 NA -0.61 -9.38 -0.46 1.14e-18 Ejection fraction in Tripanosoma cruzi seropositivity; CRC cis rs796364 1.000 rs11680723 chr2:200810957 C/G cg25936922 chr2:200820526 C2orf60;C2orf47 -0.74 -7.07 -0.36 9.17e-12 Schizophrenia; CRC cis rs7618501 0.633 rs2856234 chr3:50139142 A/G cg24308560 chr3:49941425 MST1R 0.54 9.05 0.45 1.28e-17 Intelligence (multi-trait analysis); CRC cis rs7584330 0.554 rs77180399 chr2:238442951 G/A cg08992911 chr2:238395768 MLPH 0.59 5.91 0.31 8.33e-9 Prostate cancer; CRC cis rs801193 1.000 rs3778909 chr7:66255646 G/C cg25985355 chr7:65971099 NA -0.32 -5.63 -0.3 3.82e-8 Aortic root size; CRC cis rs758324 0.947 rs1846650 chr5:131158767 C/T cg06307176 chr5:131281290 NA 0.42 6.23 0.32 1.45e-9 Alzheimer's disease in APOE e4- carriers; CRC cis rs4731207 0.596 rs6942997 chr7:124648479 T/C cg23710748 chr7:124431027 NA -0.38 -6.06 -0.32 3.73e-9 Cutaneous malignant melanoma; CRC cis rs7584330 0.657 rs10202292 chr2:238352185 A/T cg14458575 chr2:238380390 NA 0.67 11.52 0.54 5.1e-26 Prostate cancer; CRC cis rs863345 0.967 rs5009954 chr1:158530417 A/G cg12129480 chr1:158549410 OR10X1 -0.26 -5.66 -0.3 3.35e-8 Pneumococcal bacteremia; CRC cis rs62103177 0.525 rs4283293 chr18:77759582 A/G cg02751453 chr18:77725136 HSBP1L1 0.46 5.74 0.3 2.16e-8 Opioid sensitivity; CRC cis rs6834538 0.558 rs6839861 chr4:113416629 C/G cg10021238 chr4:113569128 MIR367;LARP7 -0.37 -5.77 -0.3 1.81e-8 Free thyroxine concentration; CRC cis rs34779708 0.966 rs17499247 chr10:35426755 A/G cg03585969 chr10:35415529 CREM 0.55 7.41 0.38 1.08e-12 Inflammatory bowel disease;Crohn's disease; CRC cis rs554111 0.560 rs592060 chr1:21050958 A/G cg08890418 chr1:21044141 KIF17 -0.34 -5.75 -0.3 2.01e-8 Facial morphology (factor 17, height of vermillion upper lip); CRC trans rs12478296 0.581 rs56142391 chr2:242992248 C/T cg06834434 chr14:75079333 LTBP2 0.55 7.02 0.36 1.25e-11 Obesity-related traits; CRC cis rs2976388 0.609 rs2717603 chr8:143803193 T/C cg22687807 chr8:143858763 LYNX1 0.5 8.91 0.44 3.5e-17 Urinary tract infection frequency; CRC cis rs72781680 0.950 rs56128748 chr2:24126809 T/G cg08917208 chr2:24149416 ATAD2B 0.87 8.44 0.42 1.04e-15 Lymphocyte counts; CRC cis rs6502050 0.835 rs67149434 chr17:80128007 G/A cg02741985 chr17:80059408 CCDC57 0.44 7.24 0.37 3.25e-12 Life satisfaction; CRC cis rs4713118 0.621 rs4713132 chr6:28034035 A/G cg02631126 chr6:28058918 ZSCAN12L1 0.28 5.95 0.31 6.79e-9 Parkinson's disease; CRC cis rs7208859 0.725 rs9910051 chr17:29161202 A/T cg13385521 chr17:29058706 SUZ12P 0.56 7.32 0.37 1.98e-12 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs13191362 0.935 rs4273664 chr6:162955494 T/G cg23758597 chr6:163146217 PARK2 -0.55 -5.6 -0.3 4.45e-8 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs1448094 0.512 rs60986162 chr12:86247054 T/G cg02569458 chr12:86230093 RASSF9 0.43 7.41 0.38 1.06e-12 Major depressive disorder; CRC cis rs1891275 0.508 rs7099557 chr10:93445364 C/G cg07889827 chr10:93443413 NA -0.4 -6.9 -0.36 2.75e-11 Intelligence (multi-trait analysis); CRC cis rs344364 0.511 rs1742464 chr16:1947335 A/G cg09830162 chr16:1889614 FAHD1;C16orf73 0.76 9.51 0.46 4.31e-19 Glomerular filtration rate in chronic kidney disease; CRC cis rs501120 0.584 rs11238892 chr10:44671194 A/G cg09554077 chr10:44749378 NA -0.73 -8.2 -0.41 5.35e-15 Coronary artery disease;Coronary heart disease; CRC cis rs11628318 0.853 rs28444760 chr14:103041148 A/G cg08075719 chr14:103021372 NA -0.71 -9.73 -0.47 7.79e-20 Platelet count; CRC cis rs9916302 0.904 rs12452509 chr17:37574722 G/A cg15445000 chr17:37608096 MED1 0.43 9.48 0.46 5.3e-19 Glomerular filtration rate (creatinine); CRC cis rs4713118 0.662 rs9468274 chr6:28026077 G/T cg25164649 chr6:28176230 NA 0.65 8.57 0.43 4.18e-16 Parkinson's disease; CRC cis rs7591163 0.883 rs16824023 chr2:228720877 G/A cg00063174 chr2:228736253 WDR69 -0.45 -6.35 -0.33 7.29e-10 Blood pressure; CRC cis rs7845219 0.544 rs6987400 chr8:95921295 T/C cg16049864 chr8:95962084 TP53INP1 -0.44 -6.76 -0.35 6.15e-11 Type 2 diabetes; CRC cis rs34779708 0.733 rs4102764 chr10:35545392 T/C cg03585969 chr10:35415529 CREM 0.54 6.86 0.35 3.46e-11 Inflammatory bowel disease;Crohn's disease; CRC cis rs6728642 0.908 rs11901495 chr2:98017804 A/G cg26665480 chr2:98280029 ACTR1B 0.52 6.22 0.32 1.48e-9 Bipolar disorder lithium response (continuous) or schizophrenia; CRC cis rs317689 0.918 rs610192 chr12:69739941 T/C cg20891283 chr12:69753455 YEATS4 0.64 8.23 0.41 4.31e-15 Response to diuretic therapy; CRC cis rs11864453 0.713 rs9926156 chr16:72142895 G/C cg23815491 chr16:72088622 HP 0.51 7.86 0.4 5.56e-14 Fibrinogen levels; CRC cis rs17376456 0.877 rs13173952 chr5:93307557 A/T cg09848695 chr5:92956644 FAM172A;MIR2277 0.63 5.9 0.31 9e-9 Diabetic retinopathy; CRC cis rs10979 1.000 rs9386033 chr6:143888520 T/C cg25407410 chr6:143891975 LOC285740 -0.82 -13.4 -0.59 5.5e-33 Hypospadias; CRC cis rs514406 0.823 rs501006 chr1:53368292 T/A cg27535305 chr1:53392650 SCP2 -0.37 -6.7 -0.35 9.3e-11 Monocyte count; CRC cis rs556990 0.760 rs3024739 chr13:113819948 G/A cg00898013 chr13:113819073 PROZ -0.61 -8.47 -0.42 8.14e-16 Blood protein levels; CRC cis rs8060686 0.641 rs12447640 chr16:68150527 A/G cg26727032 chr16:67993705 SLC12A4 -0.55 -6.3 -0.33 9.82e-10 HDL cholesterol;Metabolic syndrome; CRC cis rs79387448 0.745 rs7575867 chr2:103120179 C/T cg09003973 chr2:102972529 NA 0.61 6.85 0.35 3.63e-11 Gut microbiota (bacterial taxa); CRC cis rs73206853 0.841 rs7297096 chr12:110798322 G/C cg12870014 chr12:110450643 ANKRD13A 0.79 7.51 0.38 5.56e-13 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg04633058 chr17:48474099 LRRC59 0.51 7.04 0.36 1.12e-11 Thyroid stimulating hormone; CRC trans rs7613875 0.580 rs2624819 chr3:50010571 G/T cg21659725 chr3:3221576 CRBN 0.46 6.8 0.35 5.02e-11 Body mass index; CRC cis rs853679 0.825 rs8180562 chr6:28141460 G/A cg03623178 chr6:28175578 NA 0.79 6.36 0.33 6.62e-10 Depression; CRC cis rs10504229 1.000 rs6989060 chr8:58178989 T/G cg24829409 chr8:58192753 C8orf71 -0.68 -11.34 -0.53 2.27e-25 Developmental language disorder (linguistic errors); CRC cis rs11764590 0.715 rs9969125 chr7:2088460 C/T cg23378565 chr7:2036160 MAD1L1 -0.41 -5.67 -0.3 3.19e-8 Neuroticism; CRC cis rs10256972 0.713 rs10435026 chr7:1065948 A/G cg03923535 chr7:1197113 ZFAND2A 0.48 6.58 0.34 1.89e-10 Longevity;Endometriosis; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg09188840 chr17:4699533 PSMB6 -0.4 -6.01 -0.31 5.04e-9 Myopia (pathological); CRC trans rs8073060 0.586 rs226090 chr17:34034059 C/T cg19694781 chr19:47549865 TMEM160 -1.08 -14.73 -0.63 4.38e-38 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; CRC cis rs8044995 0.563 rs61602448 chr16:68377520 C/T cg05110241 chr16:68378359 PRMT7 -0.76 -7.83 -0.4 6.65e-14 Schizophrenia; CRC cis rs208520 0.661 rs207111 chr6:66792513 C/T cg07460842 chr6:66804631 NA -1.09 -15.38 -0.65 1.37e-40 Exhaled nitric oxide output; CRC cis rs6500395 1.000 rs1386040 chr16:48631207 A/G cg04672837 chr16:48644449 N4BP1 0.45 6.75 0.35 6.7e-11 Response to tocilizumab in rheumatoid arthritis; CRC cis rs68170813 0.522 rs12535814 chr7:107038432 A/T cg02696742 chr7:106810147 HBP1 -0.53 -5.88 -0.31 1e-8 Coronary artery disease; CRC cis rs7119 0.717 rs12901471 chr15:77818992 A/G cg10437265 chr15:77819839 NA 0.68 12.17 0.56 2.11e-28 Type 2 diabetes; CRC cis rs11195062 0.521 rs6584977 chr10:111954970 C/T cg00817464 chr10:111662876 XPNPEP1 -0.45 -6.93 -0.36 2.18e-11 Multiple myeloma; CRC cis rs11711311 1.000 rs34475696 chr3:113458293 T/C cg15478005 chr3:113465772 ATP6V1A;NAA50 0.45 6.31 0.33 8.92e-10 IgG glycosylation; CRC cis rs9322193 0.884 rs9383865 chr6:150173179 A/G cg07701084 chr6:150067640 NUP43 0.48 6.75 0.35 6.85e-11 Lung cancer; CRC cis rs67311347 1.000 rs11714032 chr3:40431605 G/A cg24209194 chr3:40518798 ZNF619 0.41 5.6 0.3 4.46e-8 Renal cell carcinoma; CRC cis rs7191439 0.858 rs4238685 chr16:88775220 T/C cg27087555 chr16:88793112 FAM38A -1.46 -12.25 -0.56 1.11e-28 Plateletcrit; CRC trans rs9650657 0.615 rs4840519 chr8:10693113 T/C cg06636001 chr8:8085503 FLJ10661 -0.4 -6.02 -0.31 4.72e-9 Neuroticism; CRC cis rs28374715 0.662 rs28493087 chr15:41486504 G/A cg18705301 chr15:41695430 NDUFAF1 -0.93 -13.84 -0.61 1.25e-34 Ulcerative colitis; CRC cis rs478304 0.651 rs10896038 chr11:65505528 G/C cg27068330 chr11:65405492 SIPA1 -0.66 -10.19 -0.49 2.28e-21 Acne (severe); CRC cis rs853679 0.517 rs3757187 chr6:28107654 T/C cg15786705 chr6:28176104 NA 0.77 9.75 0.47 6.92e-20 Depression; CRC cis rs10504229 0.683 rs17194487 chr8:58104912 C/T cg02725872 chr8:58115012 NA -0.54 -7.49 -0.38 6.34e-13 Developmental language disorder (linguistic errors); CRC cis rs6424115 1.000 rs2256179 chr1:24132305 A/G cg10978503 chr1:24200527 CNR2 -0.49 -8.95 -0.44 2.62e-17 Immature fraction of reticulocytes; CRC cis rs5167 0.566 rs5120 chr19:45451620 T/A cg13119609 chr19:45449297 APOC2 0.36 6.67 0.35 1.09e-10 Blood protein levels; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg10330149 chr12:112820238 NA 0.42 6.56 0.34 2.06e-10 Intelligence (multi-trait analysis); CRC trans rs2228479 0.850 rs3785279 chr16:89824562 G/C cg24644049 chr4:85504048 CDS1 0.86 6.93 0.36 2.29e-11 Skin colour saturation; CRC cis rs78456975 1.000 rs6712176 chr2:1556393 C/T cg26248373 chr2:1572462 NA -0.65 -7.15 -0.37 5.76e-12 Placebo response in major depressive disorder (% change in symptom score); CRC cis rs1150668 0.745 rs213238 chr6:28321993 T/C cg03623178 chr6:28175578 NA 0.56 8.11 0.41 1.04e-14 Pubertal anthropometrics; CRC cis rs10504229 0.728 rs72650856 chr8:58152695 C/T cg02725872 chr8:58115012 NA -0.57 -9.07 -0.45 1.09e-17 Developmental language disorder (linguistic errors); CRC cis rs12701220 0.689 rs12536282 chr7:1115650 C/T cg02733842 chr7:1102375 C7orf50 -0.91 -11.62 -0.54 2.25e-26 Bronchopulmonary dysplasia; CRC cis rs13118159 0.836 rs2276903 chr4:1343405 A/G cg21620606 chr4:1342894 KIAA1530 0.53 9.69 0.47 1.04e-19 Longevity; CRC cis rs877282 0.755 rs2486579 chr10:785647 G/A cg17470449 chr10:769945 NA 0.46 6.35 0.33 7.26e-10 Uric acid levels; CRC cis rs897984 0.806 rs12928852 chr16:30943988 C/T cg00531865 chr16:30841666 NA 0.5 7.03 0.36 1.2e-11 Dementia with Lewy bodies; CRC cis rs12928939 0.954 rs8057568 chr16:71811995 G/A cg03805757 chr16:71968109 PKD1L3 -0.47 -6.06 -0.32 3.75e-9 Post bronchodilator FEV1; CRC cis rs5769707 1.000 rs5769707 chr22:50013402 G/T cg10356904 chr22:49881777 NA -0.34 -6.49 -0.34 3.12e-10 Monocyte count;Monocyte percentage of white cells; CRC cis rs4664293 0.647 rs7595044 chr2:160446205 T/A cg08347373 chr2:160653686 CD302 -0.38 -6.48 -0.34 3.42e-10 Monocyte percentage of white cells; CRC cis rs365302 1.000 rs485557 chr6:159651303 C/T cg14500486 chr6:159655392 FNDC1 0.44 6.78 0.35 5.7e-11 Coronary heart disease; CRC cis rs55883249 0.957 rs62119393 chr2:9718247 C/T cg23886495 chr2:9695866 ADAM17 0.51 5.73 0.3 2.21e-8 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; CRC cis rs713587 0.525 rs1541984 chr2:25082414 G/A cg04586622 chr2:25135609 ADCY3 -0.56 -10.58 -0.5 1.06e-22 Body mass index in non-asthmatics; CRC trans rs61931739 0.534 rs1912773 chr12:34097401 T/C cg26384229 chr12:38710491 ALG10B 0.54 6.95 0.36 1.99e-11 Morning vs. evening chronotype; CRC cis rs6502050 0.761 rs13949 chr17:80059596 T/C cg22110888 chr17:80059540 CCDC57 -0.45 -6.88 -0.35 2.95e-11 Life satisfaction; CRC cis rs8044995 0.563 rs61746794 chr16:68387457 C/T cg05110241 chr16:68378359 PRMT7 -0.76 -7.58 -0.39 3.49e-13 Schizophrenia; CRC cis rs950169 1.000 rs35658069 chr15:84780146 C/T cg17507749 chr15:85114479 UBE2QP1 0.77 11.97 0.55 1.2100000000000001e-27 Schizophrenia; CRC cis rs79839061 0.610 rs62297062 chr4:869698 C/T cg07828340 chr4:882639 GAK 1.12 10.91 0.52 7.06e-24 Intelligence (multi-trait analysis); CRC cis rs875971 0.638 rs801216 chr7:66011667 T/C cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.43 -6.46 -0.34 3.8e-10 Aortic root size; CRC trans rs1814175 0.645 rs847639 chr11:49919603 C/T cg03929089 chr4:120376271 NA -0.91 -16.07 -0.66 2.65e-43 Height; CRC cis rs765787 0.530 rs12592055 chr15:45514477 C/T cg24006582 chr15:45444508 DUOX1 0.57 8.55 0.43 4.76e-16 Uric acid levels; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg09081385 chr12:120972070 RNF10 -0.46 -7.13 -0.37 6.58e-12 Liver disease severity in Alagille syndrome; CRC cis rs9910055 0.529 rs400460 chr17:42182770 A/G cg09913183 chr17:42254507 C17orf65;ASB16 -0.49 -6.96 -0.36 1.84e-11 Total body bone mineral density; CRC cis rs2239547 0.618 rs4687658 chr3:52860366 C/G cg10802521 chr3:52805072 NEK4 -0.45 -6.0 -0.31 5.32e-9 Schizophrenia; CRC trans rs1814175 0.626 rs1722008 chr11:49897676 A/T cg03929089 chr4:120376271 NA -0.94 -17.86 -0.7 2.28e-50 Height; CRC cis rs7666738 0.830 rs4292342 chr4:98959870 A/T cg05340658 chr4:99064831 C4orf37 0.6 9.36 0.46 1.25e-18 Colonoscopy-negative controls vs population controls; CRC cis rs7829975 0.502 rs7820738 chr8:8702607 C/G cg06636001 chr8:8085503 FLJ10661 -0.47 -6.9 -0.36 2.74e-11 Mood instability; CRC cis rs7772486 0.790 rs11760 chr6:146205973 G/T cg13319975 chr6:146136371 FBXO30 -0.4 -6.01 -0.31 4.89e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs11122272 0.735 rs2572252 chr1:231513653 T/C cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.54 -8.11 -0.41 1.04e-14 Hemoglobin concentration; CRC cis rs2274273 0.624 rs8014540 chr14:55841688 C/A cg10130446 chr14:55658398 DLGAP5 -0.43 -6.14 -0.32 2.41e-9 Protein biomarker; CRC cis rs9487051 0.768 rs435611 chr6:109527755 C/T cg01475377 chr6:109611718 NA -0.34 -5.91 -0.31 8.78e-9 Reticulocyte fraction of red cells; CRC cis rs2153535 0.580 rs9406162 chr6:8466196 C/T cg21535247 chr6:8435926 SLC35B3 0.49 7.4 0.38 1.14e-12 Motion sickness; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg13272327 chr3:137906213 ARMC8 0.48 6.28 0.33 1.05e-9 Thyroid stimulating hormone; CRC cis rs9916302 0.706 rs584377 chr17:37460128 G/A cg07936489 chr17:37558343 FBXL20 0.84 10.61 0.5 8.08e-23 Glomerular filtration rate (creatinine); CRC cis rs4819052 0.851 rs2838844 chr21:46670733 A/C cg02159808 chr21:46707872 POFUT2;LOC642852 0.49 6.38 0.33 5.87e-10 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs13108904 0.967 rs13150571 chr4:1278636 C/G cg00684032 chr4:1343700 KIAA1530 0.49 7.25 0.37 3.04e-12 Obesity-related traits; CRC cis rs7811142 0.830 rs6979910 chr7:99940630 A/C cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.75 10.46 0.5 2.7e-22 Platelet count; CRC cis rs16882447 0.607 rs13435967 chr5:53490881 G/T cg06461071 chr5:53490839 ARL15 -0.35 -5.75 -0.3 2e-8 Systolic blood pressure (dietary potassium intake interaction); CRC cis rs3857536 0.566 rs208463 chr6:66913962 T/A cg07460842 chr6:66804631 NA -0.66 -8.98 -0.44 2.07e-17 Blood trace element (Cu levels); CRC cis rs9902453 0.817 rs17226179 chr17:28168573 A/G cg26525008 chr17:28256777 EFCAB5;SSH2 0.57 8.74 0.43 1.18e-16 Coffee consumption (cups per day); CRC cis rs9467711 0.591 rs3734528 chr6:26022244 A/G cg08501292 chr6:25962987 TRIM38 0.84 7.85 0.4 6.01e-14 Autism spectrum disorder or schizophrenia; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg16856342 chr1:67895909 SERBP1 0.47 7.94 0.4 3.3e-14 Liver disease severity in Alagille syndrome; CRC cis rs12476592 0.602 rs262503 chr2:63860437 G/A cg10828910 chr2:63850056 LOC388955 0.49 6.19 0.32 1.76e-9 Childhood ear infection; CRC cis rs17095355 1.000 rs13377046 chr10:111729228 T/A cg00817464 chr10:111662876 XPNPEP1 -0.6 -8.2 -0.41 5.59e-15 Biliary atresia; CRC cis rs9300255 0.679 rs28583837 chr12:123863620 G/A cg00376283 chr12:123451042 ABCB9 -0.51 -5.86 -0.31 1.14e-8 Neutrophil percentage of white cells; CRC cis rs7945705 0.782 rs3763918 chr11:8819683 T/A cg21881798 chr11:8931708 C11orf17;ST5 0.51 7.45 0.38 8.03e-13 Hemoglobin concentration; CRC cis rs7131987 0.834 rs11050167 chr12:29426387 C/T cg09582351 chr12:29534625 ERGIC2 -0.35 -7.18 -0.37 4.6e-12 QT interval; CRC trans rs951252 0.504 rs11734405 chr4:146081096 C/T cg24321774 chr2:27193835 MAPRE3 0.45 6.61 0.34 1.52e-10 Hip circumference; CRC cis rs7618915 0.501 rs1468638 chr3:52748058 T/C cg05573699 chr3:52720067 GNL3;PBRM1 -0.48 -6.95 -0.36 2.01e-11 Bipolar disorder; CRC cis rs2404602 0.647 rs907593 chr15:77196953 G/A cg23625390 chr15:77176239 SCAPER -0.87 -12.79 -0.58 1.08e-30 Blood metabolite levels; CRC cis rs9733 0.544 rs2867302 chr1:150653650 T/C cg18016565 chr1:150552671 MCL1 0.46 6.75 0.35 6.5e-11 Tonsillectomy; CRC trans rs4263408 0.934 rs9683743 chr4:39703194 A/C cg26868354 chr6:35699952 LOC285847 -0.46 -6.75 -0.35 6.62e-11 Plasma amyloid beta peptide concentrations (ABx-40); CRC cis rs7274811 0.744 rs209665 chr20:32128889 T/G cg14921437 chr20:32255988 NECAB3;C20orf134 -0.44 -6.3 -0.33 9.57e-10 Height; CRC cis rs8180040 0.764 rs13062022 chr3:47169375 G/A cg27129171 chr3:47204927 SETD2 0.68 11.11 0.52 1.44e-24 Colorectal cancer; CRC trans rs11098499 0.954 rs2389802 chr4:120325732 C/A cg25214090 chr10:38739885 LOC399744 0.66 10.47 0.5 2.41e-22 Corneal astigmatism; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg12075659 chr20:19738521 NA 0.41 6.1 0.32 2.92e-9 Response to antipsychotic treatment; CRC cis rs11628318 0.515 rs11627756 chr14:103096606 C/T cg12046867 chr14:103022105 NA -0.41 -5.62 -0.3 4.02e-8 Platelet count; CRC cis rs1322512 0.920 rs2695246 chr6:152948466 T/C cg03415253 chr6:152958462 SYNE1 -0.41 -6.37 -0.33 6.5e-10 Tonometry; CRC cis rs4862750 1.000 rs4862751 chr4:187904050 G/A cg22105103 chr4:187893119 NA 0.64 11.17 0.52 8.66e-25 Lobe attachment (rater-scored or self-reported); CRC cis rs6684514 1.000 rs59468948 chr1:156288058 A/T cg16558208 chr1:156270281 VHLL 0.58 8.92 0.44 3.2e-17 Mean corpuscular hemoglobin concentration;Glycated hemoglobin levels; CRC cis rs6952808 0.595 rs3800917 chr7:2167939 A/G cg02951883 chr7:2050386 MAD1L1 0.68 10.55 0.5 1.35e-22 Bipolar disorder and schizophrenia; CRC cis rs9560113 0.573 rs7988040 chr13:112226534 C/G cg10483660 chr13:112241077 NA 0.63 11.75 0.54 7.28e-27 Menarche (age at onset); CRC cis rs11098499 0.863 rs2170276 chr4:120485824 A/C cg24375607 chr4:120327624 NA 0.48 7.24 0.37 3.2e-12 Corneal astigmatism; CRC cis rs853679 0.505 rs200992 chr6:27814677 A/G cg23259851 chr6:27775964 HIST1H2AI;HIST1H2BL 0.71 5.64 0.3 3.63e-8 Depression; CRC cis rs2976388 1.000 rs2920296 chr8:143763109 A/G cg04969067 chr8:143858791 LYNX1 -0.34 -5.82 -0.31 1.38e-8 Urinary tract infection frequency; CRC trans rs3733585 0.699 rs7694997 chr4:9947811 A/G cg26043149 chr18:55253948 FECH -0.45 -6.7 -0.35 9.14e-11 Cleft plate (environmental tobacco smoke interaction); CRC cis rs10504229 1.000 rs67705655 chr8:58177688 G/A cg22535103 chr8:58192502 C8orf71 -0.82 -12.27 -0.56 9.63e-29 Developmental language disorder (linguistic errors); CRC cis rs801193 1.000 rs2707845 chr7:66198798 C/T cg05627663 chr7:65219948 SNORA22;CCT6P1 0.42 6.12 0.32 2.6e-9 Aortic root size; CRC cis rs7493 1.000 rs7493 chr7:95034775 C/G cg21856205 chr7:94953877 PON1 0.48 6.29 0.33 1.02e-9 Yu-Zhi constitution type in type 2 diabetes; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg23365554 chr19:54975006 LENG9 0.43 6.39 0.33 5.62e-10 Intelligence (multi-trait analysis); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg12557418 chr8:110552613 EBAG9 0.45 6.45 0.34 3.88e-10 Intelligence (multi-trait analysis); CRC cis rs4930103 0.935 rs2075745 chr11:2018336 A/T cg23202291 chr11:1979235 NA 0.47 6.57 0.34 1.99e-10 DNA methylation (parent-of-origin);DNA methylation (variation); CRC trans rs11088226 0.645 rs2833904 chr21:33941089 T/C cg09050820 chr6:167586206 TCP10L2 0.83 8.82 0.44 6.75e-17 Gastritis; CRC cis rs9649213 0.574 rs13238610 chr7:97909277 T/C cg00277769 chr7:97922759 BAIAP2L1 -0.61 -10.65 -0.51 5.71e-23 Prostate cancer (SNP x SNP interaction); CRC cis rs6502050 0.769 rs8079122 chr17:80120427 G/T cg02741985 chr17:80059408 CCDC57 0.43 7.16 0.37 5.47e-12 Life satisfaction; CRC cis rs6831352 0.918 rs2602896 chr4:100046207 C/T cg12011299 chr4:100065546 ADH4 -0.52 -9.65 -0.47 1.42e-19 Alcohol dependence; CRC cis rs17270561 0.609 rs9356986 chr6:25739119 T/C cg17691542 chr6:26056736 HIST1H1C 0.73 9.26 0.45 2.71e-18 Iron status biomarkers; CRC cis rs4713118 0.621 rs4713134 chr6:28034121 T/C cg23161317 chr6:28129485 ZNF389 0.51 6.52 0.34 2.6200000000000003e-10 Parkinson's disease; CRC cis rs798554 0.723 rs798518 chr7:2777825 A/G cg04166393 chr7:2884313 GNA12 0.5 7.06 0.36 1.03e-11 Height; CRC cis rs155076 0.711 rs9550724 chr13:21885030 G/T cg25811766 chr13:21894605 NA 0.6 7.14 0.37 6.2e-12 White matter hyperintensity burden; CRC cis rs1552244 0.554 rs3846167 chr3:9996426 T/C cg18598329 chr3:10140678 FANCD2;C3orf24 -0.52 -7.53 -0.38 4.79e-13 Alzheimer's disease; CRC cis rs34779708 1.000 rs34779708 chr10:35466185 T/G cg03585969 chr10:35415529 CREM 0.61 8.27 0.41 3.39e-15 Inflammatory bowel disease;Crohn's disease; CRC cis rs2153535 0.563 rs3117071 chr6:8537908 C/T cg07606381 chr6:8435919 SLC35B3 0.68 11.07 0.52 1.94e-24 Motion sickness; CRC cis rs1005277 0.505 rs1208689 chr10:38097775 C/G cg25427524 chr10:38739819 LOC399744 -0.73 -12.81 -0.58 9.6e-31 Extrinsic epigenetic age acceleration; CRC cis rs356992 0.957 rs356979 chr2:60747743 T/C cg08426369 chr2:60753602 BCL11A 0.54 7.53 0.38 4.88e-13 Educational attainment (years of education); CRC cis rs11758351 1.000 rs16891401 chr6:26202337 G/A cg01420254 chr6:26195488 NA 0.81 8.51 0.42 6.08e-16 Gout;Renal underexcretion gout; CRC cis rs250677 1.000 rs190378 chr5:148434275 G/T cg23229984 chr5:148520753 ABLIM3 0.53 7.51 0.38 5.62e-13 Breast cancer; CRC cis rs12594515 0.967 rs11856523 chr15:45989495 C/T cg22117107 chr15:45993392 NA -0.44 -9.09 -0.45 9.56e-18 Waist circumference;Weight; CRC cis rs1552244 0.572 rs3894321 chr3:10168892 A/C cg02579736 chr3:10068473 FANCD2;CIDECP 0.99 11.52 0.54 5.15e-26 Alzheimer's disease; CRC cis rs11098499 0.866 rs6847778 chr4:120293582 A/G cg09307838 chr4:120376055 NA 0.69 10.67 0.51 4.93e-23 Corneal astigmatism; CRC cis rs2228479 0.557 rs34420680 chr16:89809171 C/T cg06558623 chr16:89946397 TCF25 1.13 10.33 0.5 7.24e-22 Skin colour saturation; CRC cis rs10791323 0.569 rs2257004 chr11:133712473 C/T cg03690763 chr11:133734501 NA -0.35 -5.86 -0.31 1.13e-8 Childhood ear infection; CRC trans rs9527727 0.876 rs9537923 chr13:58606355 T/C cg06608599 chr10:101381392 SLC25A28 0.44 6.1 0.32 2.9e-9 Intelligence (multi-trait analysis); CRC cis rs4689388 0.926 rs10937720 chr4:6295451 A/G cg00701064 chr4:6280414 WFS1 0.75 13.24 0.59 2.21e-32 Type 2 diabetes and other traits;Type 2 diabetes; CRC cis rs9649213 0.593 rs6955647 chr7:98004562 T/C cg00277769 chr7:97922759 BAIAP2L1 -0.6 -10.37 -0.5 5.45e-22 Prostate cancer (SNP x SNP interaction); CRC cis rs1580019 0.562 rs4720064 chr7:32559638 G/A cg07520158 chr7:32535189 LSM5;AVL9 0.53 7.84 0.4 6.31e-14 Cognitive ability; CRC cis rs6502050 0.835 rs11077971 chr17:80090629 A/G cg25804541 chr17:80189381 SLC16A3 -0.31 -5.95 -0.31 6.83e-9 Life satisfaction; CRC cis rs10760158 0.832 rs10739593 chr9:124021025 A/G cg14417974 chr9:124058376 GSN -0.33 -5.63 -0.3 3.9e-8 Pulse pressure; CRC cis rs9486715 0.838 rs9400034 chr6:96954566 C/T cg06623918 chr6:96969491 KIAA0776 1.02 20.45 0.75 1.42e-60 Headache; CRC cis rs10752881 1.000 rs6673559 chr1:182983197 G/C ch.1.3577855R chr1:183094577 LAMC1 0.87 15.34 0.65 1.9e-40 Colorectal cancer; CRC cis rs2227564 0.620 rs7098573 chr10:75580014 G/A cg16540259 chr10:75572220 NDST2 0.51 7.68 0.39 1.78e-13 Crohn's disease;Inflammatory bowel disease; CRC cis rs7605827 0.866 rs6717492 chr2:15538171 A/G cg19274914 chr2:15703543 NA 0.4 5.94 0.31 7.2e-9 Educational attainment (years of education); CRC cis rs911119 0.909 rs111360484 chr20:23618984 G/C cg16589663 chr20:23618590 CST3 0.62 8.01 0.4 2.01e-14 Chronic kidney disease; CRC trans rs877282 0.755 rs1769242 chr10:787896 T/C cg22713356 chr15:30763199 NA 1.0 12.36 0.56 4.57e-29 Uric acid levels; CRC cis rs7762018 0.891 rs1981069 chr6:170148837 G/A cg24289452 chr6:170231220 NA -0.57 -6.39 -0.33 5.75e-10 Thiazide-induced adverse metabolic effects in hypertensive patients; CRC cis rs9291683 0.595 rs11731110 chr4:10037346 T/C cg11266682 chr4:10021025 SLC2A9 0.53 11.08 0.52 1.85e-24 Bone mineral density; CRC cis rs7949030 0.626 rs11231144 chr11:62328038 A/G cg22862634 chr11:62369728 EML3;MTA2 0.58 10.38 0.5 5.21e-22 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; CRC cis rs7085104 0.700 rs10883785 chr10:104603588 A/G cg04362960 chr10:104952993 NT5C2 0.61 8.93 0.44 3.02e-17 Immature fraction of reticulocytes;Schizophrenia; CRC cis rs13082711 0.953 rs13096477 chr3:27490194 T/C cg02860705 chr3:27208620 NA 0.62 8.32 0.42 2.43e-15 Systolic blood pressure;Diastolic blood pressure;Blood pressure; CRC cis rs514406 0.584 rs11205997 chr1:53195271 G/C cg24675658 chr1:53192096 ZYG11B 0.69 10.61 0.5 8.49e-23 Monocyte count; CRC cis rs6835098 0.962 rs4419455 chr4:174083622 C/T cg08422745 chr4:174089978 GALNT7 0.97 15.18 0.64 7.94e-40 Dementia and core Alzheimer's disease neuropathologic changes; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg09417774 chr12:112037791 ATXN2 0.48 6.9 0.36 2.6e-11 Response to antipsychotic treatment; CRC cis rs4713118 0.911 rs2394000 chr6:27686991 A/G cg20933634 chr6:27740509 NA 0.57 7.9 0.4 4.13e-14 Parkinson's disease; CRC cis rs9322193 0.923 rs9767123 chr6:149981459 A/G cg05861140 chr6:150128134 PCMT1 -0.37 -5.96 -0.31 6.32e-9 Lung cancer; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg03205208 chr10:7830848 KIN;ATP5C1 0.44 6.43 0.33 4.57e-10 Intelligence (multi-trait analysis); CRC cis rs875971 0.520 rs12666485 chr7:65625122 T/C cg05627663 chr7:65219948 SNORA22;CCT6P1 0.6 7.73 0.39 1.29e-13 Aortic root size; CRC trans rs11885103 0.543 rs1320365 chr2:563182 A/G cg12228919 chr15:44955936 SPG11 -0.46 -6.87 -0.35 3.13e-11 Heschl's gyrus morphology; CRC cis rs853679 0.513 rs9468296 chr6:28113730 A/G cg06470822 chr6:28175283 NA 1.03 13.59 0.6 1.04e-33 Depression; CRC cis rs4132509 0.744 rs59953491 chr1:243894953 C/T cg21452805 chr1:244014465 NA 0.57 7.3 0.37 2.13e-12 RR interval (heart rate); CRC cis rs7849270 1.000 rs1360172 chr9:131907980 A/G cg13538475 chr9:131942899 NA -0.32 -6.36 -0.33 6.63e-10 Blood metabolite ratios; CRC cis rs11105298 0.891 rs11105302 chr12:89891366 A/G cg00757033 chr12:89920650 WDR51B -0.37 -6.33 -0.33 8.25e-10 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; CRC trans rs2270927 0.510 rs6876070 chr5:75579237 T/A cg13563193 chr19:33072644 PDCD5 0.68 6.15 0.32 2.29e-9 Mean corpuscular volume; CRC cis rs9427116 0.502 rs6699825 chr1:154582970 A/G cg17218026 chr1:154582156 ADAR 0.69 12.32 0.56 5.96e-29 Blood protein levels; CRC cis rs6502050 0.712 rs8077079 chr17:80059011 C/T cg13198984 chr17:80129470 CCDC57 -0.42 -7.07 -0.36 9.43e-12 Life satisfaction; CRC cis rs7208859 0.623 rs73271869 chr17:29152221 G/A cg01831904 chr17:28903510 LRRC37B2 -0.61 -6.43 -0.33 4.58e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs9902453 0.904 rs11080115 chr17:28408070 C/T cg26525008 chr17:28256777 EFCAB5;SSH2 -0.69 -11.3 -0.53 2.97e-25 Coffee consumption (cups per day); CRC cis rs4481887 1.000 rs4508046 chr1:248488988 T/C cg00666640 chr1:248458726 OR2T12 0.55 9.57 0.47 2.71e-19 Common traits (Other); CRC cis rs6582630 0.555 rs11180986 chr12:38264486 G/A cg26384229 chr12:38710491 ALG10B -0.52 -7.4 -0.38 1.13e-12 Drug-induced liver injury (flucloxacillin); CRC trans rs1005277 0.579 rs2474587 chr10:38420666 C/T cg23533926 chr12:111358616 MYL2 -0.52 -7.91 -0.4 3.95e-14 Extrinsic epigenetic age acceleration; CRC cis rs12701220 0.503 rs12702047 chr7:1132720 G/A cg04498913 chr7:1135747 C7orf50 -0.61 -6.73 -0.35 7.67e-11 Bronchopulmonary dysplasia; CRC cis rs6694672 1.000 rs1412634 chr1:197023156 T/C cg13682187 chr1:196946512 CFHR5 0.5 7.67 0.39 1.96e-13 Asthma; CRC cis rs6598955 0.724 rs3924934 chr1:26644079 A/G cg00852783 chr1:26633632 UBXN11 0.42 6.73 0.35 7.74e-11 Obesity-related traits; CRC cis rs796364 0.806 rs6743396 chr2:200860138 T/C cg25936922 chr2:200820526 C2orf60;C2orf47 0.68 6.63 0.34 1.34e-10 Schizophrenia; CRC cis rs898097 0.756 rs56249965 chr17:80806603 C/G cg15369054 chr17:80825471 TBCD 0.53 8.46 0.42 8.75e-16 Breast cancer; CRC cis rs2404602 0.575 rs11633309 chr15:76962349 C/A cg23625390 chr15:77176239 SCAPER -0.77 -10.28 -0.49 1.08e-21 Blood metabolite levels; CRC cis rs6831352 0.918 rs7669636 chr4:100059312 G/A cg13256891 chr4:100009986 ADH5 -0.65 -8.8 -0.44 7.63e-17 Alcohol dependence; CRC cis rs1448094 0.511 rs10506920 chr12:86165212 A/T cg25456477 chr12:86230367 RASSF9 0.38 6.32 0.33 8.37e-10 Major depressive disorder; CRC trans rs1005277 0.602 rs2504142 chr10:38383793 C/T cg11292332 chr7:45801988 SEPT13 -0.35 -6.26 -0.33 1.23e-9 Extrinsic epigenetic age acceleration; CRC cis rs11758351 0.660 rs11753131 chr6:26219384 G/A cg22723502 chr6:26240528 HIST1H4F -0.36 -5.85 -0.31 1.17e-8 Gout;Renal underexcretion gout; CRC cis rs3785574 0.962 rs2727324 chr17:61922102 G/C cg25654072 chr17:61904446 PSMC5;FTSJ3 0.41 5.72 0.3 2.38e-8 Height; CRC cis rs7493 1.000 rs2068604 chr7:95041542 G/T cg17330251 chr7:94953956 PON1 -0.57 -7.27 -0.37 2.7e-12 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs35883536 1.000 rs4908087 chr1:101088594 C/T cg14515779 chr1:101123966 NA -0.43 -8.37 -0.42 1.68e-15 Monocyte count; CRC cis rs8180040 0.966 rs57346147 chr3:47410564 C/G cg02527881 chr3:46936655 PTH1R 0.37 6.68 0.35 1e-10 Colorectal cancer; CRC cis rs798554 0.679 rs2527677 chr7:2882621 A/G cg04166393 chr7:2884313 GNA12 0.56 7.49 0.38 6.51e-13 Height; CRC trans rs7267979 1.000 rs2482911 chr20:25395528 T/C cg17903999 chr18:56338584 MALT1 0.41 6.81 0.35 4.6e-11 Liver enzyme levels (alkaline phosphatase); CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg25452974 chr10:89621984 PTEN;KILLIN 0.48 6.22 0.32 1.55e-9 Thyroid stimulating hormone; CRC cis rs2243480 1.000 rs55895244 chr7:65387678 C/G cg18252515 chr7:66147081 NA -1.08 -12.66 -0.57 3.44e-30 Diabetic kidney disease; CRC cis rs2070677 1.000 rs12263487 chr10:135403585 A/G cg20169779 chr10:135381914 SYCE1 -0.95 -14.97 -0.64 5.46e-39 Gout; CRC cis rs3617 0.573 rs12492391 chr3:52912296 C/A cg05573699 chr3:52720067 GNL3;PBRM1 -0.42 -6.2 -0.32 1.67e-9 Red blood cell count;Autism spectrum disorder or schizophrenia; CRC cis rs12048904 0.619 rs3737581 chr1:101341083 A/G cg15686842 chr1:101360669 SLC30A7;EXTL2 0.57 7.78 0.39 9.59e-14 Multiple sclerosis; CRC trans rs12599106 0.754 rs11640596 chr16:34347277 T/C cg18110333 chr6:292329 DUSP22 -0.58 -8.32 -0.42 2.35e-15 Menopause (age at onset); CRC cis rs1348850 0.526 rs6723063 chr2:178491398 C/T cg27490568 chr2:178487706 NA 0.82 10.02 0.48 8.31e-21 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs881375 0.678 rs10739581 chr9:123696871 C/T cg09419670 chr9:123605666 PSMD5;LOC253039 0.45 6.87 0.35 3.22e-11 Rheumatoid arthritis; CRC cis rs10751667 0.643 rs7396951 chr11:927355 G/A ch.11.42038R chr11:967971 AP2A2 0.6 10.22 0.49 1.74e-21 Alzheimer's disease (late onset); CRC cis rs60843830 1.000 rs17714252 chr2:285471 G/A cg00108164 chr2:264199 ACP1;SH3YL1 0.62 9.73 0.47 7.72e-20 Spherical equivalent (joint analysis main effects and education interaction); CRC cis rs13108904 0.870 rs2279281 chr4:1245277 T/G cg19318889 chr4:1322082 MAEA 0.42 6.43 0.33 4.57e-10 Obesity-related traits; CRC cis rs561341 1.000 rs113676348 chr17:30244327 A/G cg12193833 chr17:30244370 NA -0.69 -8.4 -0.42 1.38e-15 Hip circumference adjusted for BMI; CRC cis rs67311347 1.000 rs9854493 chr3:40423622 T/C cg09455208 chr3:40491958 NA 0.48 9.24 0.45 3.26e-18 Renal cell carcinoma; CRC cis rs4363385 0.818 rs4284210 chr1:152985711 G/A cg25856811 chr1:152973957 SPRR3 -0.24 -6.71 -0.35 8.61e-11 Inflammatory skin disease; CRC cis rs6502050 0.835 rs56232956 chr17:80078929 C/T cg11859384 chr17:80120422 CCDC57 0.37 5.77 0.3 1.85e-8 Life satisfaction; CRC cis rs7769051 0.522 rs7738256 chr6:133113066 C/G cg07930552 chr6:133119739 C6orf192 0.93 8.91 0.44 3.48e-17 Type 2 diabetes nephropathy; CRC cis rs11229555 0.645 rs11229460 chr11:58208343 T/C cg15696309 chr11:58395628 NA -0.82 -10.45 -0.5 2.81e-22 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; CRC cis rs375066 0.551 rs11879541 chr19:44331443 C/T cg19542119 chr19:44331823 ZNF283 0.41 5.74 0.3 2.1e-8 Breast cancer; CRC cis rs11628318 0.713 rs4900543 chr14:103029024 T/C cg08075719 chr14:103021372 NA -0.69 -9.17 -0.45 5.19e-18 Platelet count; CRC cis rs3733585 0.648 rs67820465 chr4:9975873 A/G cg00071950 chr4:10020882 SLC2A9 -0.56 -10.01 -0.48 8.86e-21 Cleft plate (environmental tobacco smoke interaction); CRC cis rs1218582 0.772 rs12069356 chr1:154849771 C/T cg09359103 chr1:154839909 KCNN3 -0.75 -13.76 -0.6 2.5e-34 Prostate cancer; CRC cis rs6570726 0.791 rs441290 chr6:145883183 A/G cg05347473 chr6:146136440 FBXO30 0.37 5.73 0.3 2.3e-8 Lobe attachment (rater-scored or self-reported); CRC cis rs7584330 0.704 rs11884395 chr2:238359366 C/T cg14458575 chr2:238380390 NA 0.77 14.24 0.62 3.41e-36 Prostate cancer; CRC cis rs2839186 0.771 rs2280959 chr21:47641996 C/G cg26721908 chr21:47610096 LSS -0.41 -6.31 -0.33 9.17e-10 Testicular germ cell tumor; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg14107159 chr12:56652285 ANKRD52 0.41 6.01 0.31 4.98e-9 Response to antipsychotic treatment; CRC cis rs2032447 0.670 rs198845 chr6:26107790 A/C cg03517284 chr6:25882590 NA -0.43 -5.92 -0.31 7.89e-9 Intelligence (multi-trait analysis); CRC cis rs1044826 0.597 rs6772199 chr3:139178133 C/T cg15131784 chr3:139108705 COPB2 0.39 5.69 0.3 2.79e-8 Obesity-related traits; CRC cis rs4964805 0.657 rs1866293 chr12:104186655 C/T cg02344784 chr12:104178138 NT5DC3 0.79 15.03 0.64 3.07e-39 Attention deficit hyperactivity disorder; CRC cis rs11148252 0.716 rs2760772 chr13:52780373 C/G cg12458913 chr13:53173898 NA 0.5 7.33 0.37 1.82e-12 Lewy body disease; CRC cis rs2243480 1.000 rs6964245 chr7:65718717 G/A cg12463550 chr7:65579703 CRCP -0.68 -6.14 -0.32 2.33e-9 Diabetic kidney disease; CRC cis rs2932538 0.961 rs6537746 chr1:113163529 C/T cg22162597 chr1:113214053 CAPZA1 -0.73 -10.43 -0.5 3.53e-22 Systolic blood pressure;Diastolic blood pressure;Hypertension;Blood pressure; CRC cis rs11723261 0.582 rs116471062 chr4:163522 A/G cg12746427 chr4:53362 ZNF718;ZNF595 0.5 6.87 0.35 3.27e-11 Immune response to smallpox vaccine (IL-6); CRC cis rs2011503 1.000 rs78010159 chr19:19615905 C/T cg11584989 chr19:19387371 SF4 0.57 6.39 0.33 5.7e-10 Bipolar disorder; CRC cis rs7224737 1.000 rs11079034 chr17:40288890 G/A cg02450064 chr17:40260053 DHX58 -0.42 -6.12 -0.32 2.7e-9 Fibrinogen levels; CRC cis rs2952156 1.000 rs2934967 chr17:37870378 G/A cg00129232 chr17:37814104 STARD3 -0.67 -10.88 -0.51 9.32e-24 Asthma; CRC cis rs875971 1.000 rs7789554 chr7:65946038 A/G cg00343986 chr7:65444356 GUSB 0.44 6.39 0.33 5.77e-10 Aortic root size; CRC cis rs6570726 0.791 rs414297 chr6:145887556 C/T cg23711669 chr6:146136114 FBXO30 0.66 10.96 0.52 4.98e-24 Lobe attachment (rater-scored or self-reported); CRC cis rs67478160 0.643 rs2887282 chr14:104280734 A/G cg08213375 chr14:104286397 PPP1R13B 0.6 11.62 0.54 2.22e-26 Schizophrenia; CRC cis rs7618501 0.602 rs34831713 chr3:50118748 T/C cg24110177 chr3:50126178 RBM5 0.52 8.14 0.41 8.41e-15 Intelligence (multi-trait analysis); CRC cis rs4237845 0.780 rs3751331 chr12:58290278 G/A cg00677455 chr12:58241039 CTDSP2 0.68 9.48 0.46 5.23e-19 Intelligence (multi-trait analysis); CRC cis rs2836974 0.674 rs1011413 chr21:40638241 A/G cg11644478 chr21:40555479 PSMG1 -0.69 -11.39 -0.53 1.46e-25 Cognitive function; CRC cis rs28386778 0.897 rs2584640 chr17:61863488 C/T cg06873352 chr17:61820015 STRADA 0.77 14.5 0.62 3.51e-37 Prudent dietary pattern; CRC cis rs7618915 0.508 rs12498066 chr3:52627660 G/A cg15147215 chr3:52552868 STAB1 -0.62 -10.17 -0.49 2.64e-21 Bipolar disorder; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg02406285 chr3:67048577 KBTBD8 0.42 6.82 0.35 4.33e-11 Intelligence (multi-trait analysis); CRC cis rs9914988 0.832 rs34267753 chr17:27157586 T/C cg16670446 chr17:27188758 MIR451;MIR144 0.53 8.4 0.42 1.32e-15 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs970548 0.688 rs10900228 chr10:46082128 A/G cg15590007 chr10:45870220 ALOX5 0.57 5.96 0.31 6.43e-9 Total cholesterol levels;Cholesterol, total;HDL cholesterol;HDL cholesterol levels; CRC cis rs1862618 0.756 rs13356762 chr5:56110992 G/T cg24531977 chr5:56204891 C5orf35 -0.82 -11.03 -0.52 2.73e-24 Initial pursuit acceleration; CRC cis rs79349575 0.715 rs4793997 chr17:47019672 C/A cg22482690 chr17:47019901 SNF8 0.48 8.01 0.4 2.01e-14 Type 2 diabetes; CRC cis rs1448094 0.842 rs10863159 chr12:86459140 T/C cg02569458 chr12:86230093 RASSF9 -0.4 -6.79 -0.35 5.22e-11 Major depressive disorder; CRC cis rs6938 0.618 rs11638130 chr15:75183935 G/A cg18612461 chr15:75251733 NA 0.4 6.18 0.32 1.94e-9 Breast cancer; CRC cis rs35306767 0.855 rs12774985 chr10:904245 C/T cg26597838 chr10:835615 NA 1.26 14.99 0.64 4.41e-39 Eosinophil percentage of granulocytes; CRC trans rs2727020 0.521 rs7131163 chr11:49574774 C/T cg03929089 chr4:120376271 NA -0.76 -10.09 -0.49 4.98e-21 Coronary artery disease; CRC cis rs2032447 0.901 rs1540276 chr6:26028819 T/G cg27635394 chr6:26043820 HIST1H2BB 0.44 6.34 0.33 7.52e-10 Intelligence (multi-trait analysis); CRC trans rs7267979 1.000 rs2257988 chr20:25270003 T/C cg17903999 chr18:56338584 MALT1 -0.41 -6.89 -0.36 2.82e-11 Liver enzyme levels (alkaline phosphatase); CRC cis rs7493 0.806 rs17876090 chr7:95053404 A/T cg21856205 chr7:94953877 PON1 -0.53 -6.67 -0.35 1.1e-10 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs7632954 0.669 rs7642129 chr3:8530748 C/T cg03495237 chr3:8533978 NA 0.36 6.61 0.34 1.54e-10 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs2032447 0.802 rs198853 chr6:26104096 T/C cg03517284 chr6:25882590 NA 0.46 6.18 0.32 1.94e-9 Intelligence (multi-trait analysis); CRC cis rs6543140 0.964 rs918000 chr2:103067862 C/T cg04239558 chr2:103089729 SLC9A4 0.37 6.6 0.34 1.64e-10 Blood protein levels; CRC cis rs9467603 0.547 rs7774567 chr6:25425526 C/T cg16898833 chr6:26189333 HIST1H4D 0.69 5.68 0.3 2.92e-8 Intelligence (multi-trait analysis); CRC cis rs7626444 0.563 rs2686598 chr3:196487719 C/T cg12930392 chr3:196481615 PAK2 0.4 7.13 0.37 6.28e-12 Monocyte count; CRC cis rs9733 0.569 rs11204691 chr1:150644339 A/T cg15448220 chr1:150897856 SETDB1 0.45 6.43 0.33 4.42e-10 Tonsillectomy; CRC cis rs7937840 0.581 rs4963286 chr11:61887232 C/A cg01969543 chr11:61895209 INCENP -0.47 -6.47 -0.34 3.51e-10 Breast cancer; CRC cis rs853679 0.517 rs9380056 chr6:28104476 C/T cg25164649 chr6:28176230 NA 0.76 9.53 0.46 3.71e-19 Depression; CRC cis rs10992471 0.603 rs11792019 chr9:95195229 C/T cg14631576 chr9:95140430 CENPP -0.41 -7.24 -0.37 3.14e-12 Visceral adipose tissue/subcutaneous adipose tissue ratio; CRC cis rs72634258 0.503 rs72632055 chr1:7835774 T/G cg26816564 chr1:7831052 VAMP3 0.89 9.9 0.48 2.2e-20 Inflammatory bowel disease; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg09378111 chr2:211036309 C2orf67 0.45 6.41 0.33 5.14e-10 Response to antipsychotic treatment; CRC cis rs362272 0.524 rs3129334 chr4:3368526 T/C cg08741688 chr4:3415352 RGS12 -0.4 -5.74 -0.3 2.19e-8 Serum sulfate level; CRC cis rs1218582 0.772 rs10796935 chr1:154891363 G/T cg03351412 chr1:154909251 PMVK 0.55 8.85 0.44 5.5e-17 Prostate cancer; CRC cis rs3806843 0.966 rs2563264 chr5:140137503 T/G cg19875535 chr5:140030758 IK -0.55 -8.8 -0.44 7.81e-17 Depressive symptoms (multi-trait analysis); CRC cis rs2281845 0.507 rs1536127 chr1:201086894 C/A cg08885800 chr1:201084119 NA 0.43 6.19 0.32 1.83e-9 Permanent tooth development; CRC trans rs2303319 0.504 rs62187655 chr2:162487440 C/G cg10272801 chr16:14013773 ERCC4 -0.69 -6.02 -0.31 4.59e-9 Cognitive function; CRC cis rs7216064 1.000 rs7221651 chr17:65832390 A/G cg12091567 chr17:66097778 LOC651250 0.65 8.28 0.42 3.1e-15 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CRC cis rs10504229 1.000 rs72650899 chr8:58180525 G/T cg05313129 chr8:58192883 C8orf71 -0.47 -6.99 -0.36 1.49e-11 Developmental language disorder (linguistic errors); CRC cis rs17065868 0.764 rs61949798 chr13:45034464 G/A cg10246903 chr13:45222710 NA 0.54 5.69 0.3 2.79e-8 Antineutrophil cytoplasmic antibody-associated vasculitis; CRC cis rs57994353 0.861 rs34302850 chr9:139327064 A/G cg14119001 chr9:139324193 INPP5E -0.41 -6.02 -0.32 4.58e-9 Eosinophil counts;Cutaneous squamous cell carcinoma; CRC cis rs4689388 0.856 rs1046314 chr4:6303955 A/G cg25554036 chr4:6271136 WFS1 -0.51 -8.13 -0.41 8.85e-15 Type 2 diabetes and other traits;Type 2 diabetes; CRC trans rs6703335 0.870 rs10803142 chr1:243598234 A/G cg12588638 chr12:83080208 TMTC2 0.44 6.4 0.33 5.28e-10 Schizophrenia;Schizophrenia, schizoaffective disorder or bipolar disorder; CRC cis rs995000 0.965 rs1168022 chr1:63007721 A/T cg19896129 chr1:63156450 NA -0.44 -6.81 -0.35 4.6e-11 Triglyceride levels; CRC cis rs3733585 0.699 rs4621431 chr4:9947590 C/T cg00071950 chr4:10020882 SLC2A9 -0.56 -9.71 -0.47 9.27e-20 Cleft plate (environmental tobacco smoke interaction); CRC cis rs782590 0.935 rs2627776 chr2:55873301 T/A cg18811423 chr2:55921094 PNPT1 0.81 14.97 0.64 5.47e-39 Metabolic syndrome; CRC cis rs6952808 0.609 rs4721190 chr7:1954732 A/G cg21782813 chr7:2030301 MAD1L1 -0.43 -7.79 -0.39 8.82e-14 Bipolar disorder and schizophrenia; CRC trans rs17270561 0.609 rs1165155 chr6:25795577 A/T cg02936872 chr9:99801550 CTSL2 0.48 6.18 0.32 1.85e-9 Iron status biomarkers; CRC cis rs73200209 0.744 rs3214009 chr12:116486852 C/T cg01776926 chr12:116560359 MED13L 0.64 7.3 0.37 2.19e-12 Total body bone mineral density; CRC cis rs4713118 0.513 rs156739 chr6:28013410 C/A cg15786705 chr6:28176104 NA 0.59 8.47 0.42 8.49e-16 Parkinson's disease; CRC trans rs12599106 0.629 rs1391904 chr16:34548934 C/T cg01516881 chr6:292596 DUSP22 -0.57 -8.31 -0.42 2.59e-15 Menopause (age at onset); CRC cis rs7552404 0.924 rs2173378 chr1:76201992 G/T cg22875332 chr1:76189707 ACADM 0.69 10.51 0.5 1.78e-22 Blood metabolite levels;Acylcarnitine levels; CRC cis rs10791323 0.604 rs2723598 chr11:133711652 G/A cg03690763 chr11:133734501 NA -0.35 -5.86 -0.31 1.13e-8 Childhood ear infection; CRC cis rs12530845 0.623 rs73721677 chr7:135354238 C/A cg23117316 chr7:135346802 PL-5283 -0.5 -6.41 -0.33 5.04e-10 Red blood cell traits; CRC cis rs11112613 0.713 rs11112588 chr12:105943801 A/C cg03607813 chr12:105948248 NA 0.81 10.71 0.51 3.6e-23 Corrected insulin response;Corrected insulin response adjusted for insulin sensitivity index; CRC cis rs7737355 0.853 rs593767 chr5:131043660 T/G cg06307176 chr5:131281290 NA 0.41 5.97 0.31 6.2e-9 Life satisfaction; CRC cis rs9914988 0.943 rs12453504 chr17:27119524 C/A cg12682573 chr17:27188876 MIR451;MIR144 0.58 7.99 0.4 2.37e-14 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs875971 0.545 rs6460276 chr7:65647277 G/A cg05627663 chr7:65219948 SNORA22;CCT6P1 0.59 7.76 0.39 1.05e-13 Aortic root size; CRC cis rs4253772 0.550 rs6008598 chr22:46704243 C/T cg03482458 chr22:46692211 CN5H6.4;GTSE1 0.49 6.15 0.32 2.29e-9 LDL cholesterol;Cholesterol, total; CRC cis rs739401 0.611 rs7109088 chr11:3027485 G/T cg05729581 chr11:3078854 CARS -0.59 -8.75 -0.43 1.16e-16 Longevity; CRC trans rs6600671 0.902 rs2222371 chr1:121289118 T/C cg09829573 chr1:144692074 NBPF9 0.41 6.1 0.32 3.03e-9 Hip geometry; CRC cis rs9303542 0.625 rs7222242 chr17:46565486 C/A cg04904318 chr17:46607828 HOXB1 -0.5 -5.75 -0.3 2.04e-8 Ovarian cancer;Epithelial ovarian cancer; CRC cis rs6502050 0.835 rs7221451 chr17:80089785 A/G cg09264619 chr17:80180166 NA -0.36 -5.91 -0.31 8.79e-9 Life satisfaction; CRC cis rs9837602 1.000 rs1021103 chr3:99603230 G/A cg07805332 chr3:99536008 MIR548G;C3orf26 -0.47 -6.35 -0.33 6.99e-10 Breast cancer; CRC cis rs11212617 0.840 rs172894 chr11:108262090 C/A cg14761454 chr11:108092087 ATM;NPAT 0.39 5.72 0.3 2.43e-8 Response to metformin in type 2 diabetes (glycemic); CRC cis rs6741892 0.536 rs13024840 chr2:38895920 T/A cg20799917 chr2:38894198 GALM -0.47 -5.64 -0.3 3.66e-8 5-HTT brain serotonin transporter levels; CRC cis rs3008870 0.959 rs2815353 chr1:67483372 A/G cg08660285 chr1:67390436 MIER1;WDR78 1.04 15.42 0.65 9.52e-41 Lymphocyte percentage of white cells; CRC trans rs3733585 0.699 rs10001964 chr4:9959275 C/T cg26043149 chr18:55253948 FECH -0.5 -7.62 -0.39 2.7e-13 Cleft plate (environmental tobacco smoke interaction); CRC cis rs6582630 0.537 rs3942440 chr12:38459672 A/G cg13010199 chr12:38710504 ALG10B 0.49 6.58 0.34 1.87e-10 Drug-induced liver injury (flucloxacillin); CRC cis rs524281 0.773 rs2236651 chr11:66001418 C/T cg14036092 chr11:66035641 RAB1B -0.56 -6.35 -0.33 7.22e-10 Electroencephalogram traits; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg00838150 chr3:69788442 MITF 0.44 6.38 0.33 6.05e-10 Response to antipsychotic treatment; CRC trans rs2797160 1.000 rs1777183 chr6:126011995 A/C cg05039488 chr6:79577232 IRAK1BP1 0.5 7.51 0.38 5.69e-13 Endometrial cancer; CRC cis rs40363 0.857 rs55989968 chr16:3530658 C/G cg02880119 chr16:3481970 NA 0.49 5.62 0.3 4.08e-8 Tuberculosis; CRC cis rs2882667 0.931 rs10038799 chr5:138362283 C/T cg04439458 chr5:138467593 SIL1 -0.33 -6.0 -0.31 5.3300000000000004e-09 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs7212590 0.748 rs9904374 chr17:57908096 T/C cg10252138 chr17:58120427 NA -0.55 -5.84 -0.31 1.24e-8 Granulocyte percentage of myeloid white cells;Monocyte count;Monocyte percentage of white cells; CRC cis rs9393692 0.620 rs9358916 chr6:26283185 G/A cg00631329 chr6:26305371 NA -0.54 -9.24 -0.45 3.04e-18 Educational attainment; CRC cis rs3741404 0.825 rs11603538 chr11:63986713 C/A cg18225595 chr11:63971243 STIP1 0.63 10.62 0.51 7.75e-23 Platelet count; CRC cis rs6426558 0.537 rs488104 chr1:227300277 G/A cg10327440 chr1:227177885 CDC42BPA 0.45 6.79 0.35 5.1e-11 Neutrophil percentage of white cells; CRC cis rs67340775 0.541 rs200979 chr6:27852357 G/A cg02683197 chr6:28174875 NA 0.67 6.55 0.34 2.27e-10 Lung cancer in ever smokers; CRC cis rs9393777 0.841 rs34332556 chr6:27357414 C/G cg15845792 chr6:28175446 NA 0.86 5.61 0.3 4.22e-8 Intelligence (multi-trait analysis); CRC cis rs62158211 0.565 rs2121243 chr2:114099346 C/T cg17784749 chr2:114082611 LOC440839 0.47 6.23 0.33 1.39e-9 Sleep duration (oversleepers vs undersleepers);Sleep traits (multi-trait analysis);Sleep duration; CRC cis rs10504229 0.683 rs7827014 chr8:58132230 G/A cg04204079 chr8:58130323 NA -0.45 -5.78 -0.3 1.71e-8 Developmental language disorder (linguistic errors); CRC cis rs4664293 1.000 rs6753181 chr2:160492438 C/A cg08347373 chr2:160653686 CD302 -0.45 -7.25 -0.37 2.93e-12 Monocyte percentage of white cells; CRC cis rs2180341 1.000 rs3798850 chr6:127613966 C/T cg27446573 chr6:127587934 RNF146 0.99 14.76 0.63 3.48e-38 Breast cancer; CRC cis rs9303280 0.617 rs8079416 chr17:38092713 T/C cg24910161 chr17:38119198 GSDMA -0.32 -5.72 -0.3 2.4e-8 Self-reported allergy; CRC cis rs4713118 0.513 rs149944 chr6:28002818 C/T cg12172441 chr6:28176163 NA 0.51 7.26 0.37 2.76e-12 Parkinson's disease; CRC cis rs910316 0.737 rs175065 chr14:75494983 T/C cg08847533 chr14:75593920 NEK9 -0.84 -14.43 -0.62 6.63e-37 Height; CRC cis rs3760982 0.626 rs12463370 chr19:44292166 G/A cg12072164 chr19:44306565 LYPD5 0.41 6.45 0.34 3.97e-10 Breast cancer (estrogen-receptor negative);Breast cancer; CRC trans rs10982213 0.830 rs2274163 chr9:117188714 C/T cg00760200 chr1:115053833 TRIM33 0.44 6.86 0.35 3.37e-11 Interleukin-6 levels; CRC cis rs4731207 0.596 rs2127971 chr7:124595309 G/C cg23710748 chr7:124431027 NA -0.38 -6.08 -0.32 3.35e-9 Cutaneous malignant melanoma; CRC cis rs10504229 0.593 rs113184543 chr8:58042950 A/G cg02725872 chr8:58115012 NA -0.37 -6.43 -0.33 4.51e-10 Developmental language disorder (linguistic errors); CRC cis rs2075371 1.000 rs447266 chr7:133989543 A/G cg11752832 chr7:134001865 SLC35B4 0.49 7.69 0.39 1.69e-13 Mean platelet volume; CRC cis rs4243830 0.522 rs10864614 chr1:6596008 G/A cg22792644 chr1:6614718 TAS1R1;NOL9 -0.79 -9.53 -0.47 3.6e-19 Body mass index; CRC cis rs11098499 0.909 rs1546504 chr4:120241179 C/T cg09307838 chr4:120376055 NA 0.7 10.55 0.5 1.35e-22 Corneal astigmatism; CRC cis rs9911578 1.000 rs4636974 chr17:56965373 C/G cg05425664 chr17:57184151 TRIM37 -0.49 -7.67 -0.39 1.91e-13 Intelligence (multi-trait analysis); CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg07573057 chr8:82754234 SNX16 0.52 6.75 0.35 6.76e-11 Thyroid stimulating hormone; CRC cis rs2745967 0.740 rs2785645 chr1:208067420 A/G cg09788693 chr1:208063733 CD34 0.47 7.04 0.36 1.13e-11 Resting heart rate; CRC cis rs2576037 0.526 rs1789152 chr18:44433092 G/T cg19077165 chr18:44547161 KATNAL2 -0.57 -9.62 -0.47 1.8e-19 Personality dimensions; CRC cis rs9420 0.961 rs71484461 chr11:57488890 G/A cg23127183 chr11:57508653 C11orf31 -0.53 -7.16 -0.37 5.32e-12 Schizophrenia; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg10260072 chr6:42421084 TRERF1 0.41 6.65 0.34 1.2e-10 Liver disease severity in Alagille syndrome; CRC trans rs6472235 0.837 rs7465415 chr8:66920522 T/G cg07884673 chr3:53033167 SFMBT1 -0.46 -6.15 -0.32 2.31e-9 Myopia (pathological);Plateletcrit; CRC cis rs2073300 0.609 rs6137915 chr20:23358509 A/G cg12062639 chr20:23401060 NAPB -0.66 -6.4 -0.33 5.32e-10 Peripheral arterial disease (traffic-related air pollution interaction); CRC trans rs2727020 0.664 rs4929893 chr11:49196332 C/T cg03929089 chr4:120376271 NA -0.78 -12.81 -0.58 9.06e-31 Coronary artery disease; CRC cis rs10504229 0.683 rs11775506 chr8:58133639 G/T cg02725872 chr8:58115012 NA -0.64 -11.39 -0.53 1.41e-25 Developmental language disorder (linguistic errors); CRC cis rs35264875 1.000 rs72928636 chr11:68848386 C/T cg23740940 chr11:68924746 NA 0.44 5.75 0.3 2.04e-8 Blond vs. brown hair color; CRC cis rs9427116 0.840 rs9427114 chr1:154626705 T/C cg17218026 chr1:154582156 ADAR 0.57 9.01 0.44 1.68e-17 Blood protein levels; CRC cis rs875971 0.862 rs778697 chr7:65870426 G/A cg18252515 chr7:66147081 NA -0.42 -5.99 -0.31 5.64e-9 Aortic root size; CRC cis rs4718428 0.705 rs4717331 chr7:66378886 C/T cg12165864 chr7:66369176 NA -0.42 -5.85 -0.31 1.16e-8 Corneal structure; CRC cis rs7208859 0.623 rs1061343 chr17:29114276 G/A cg13385521 chr17:29058706 SUZ12P 0.74 8.44 0.42 9.97e-16 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs8180040 0.701 rs11130111 chr3:47009805 C/T cg02527881 chr3:46936655 PTH1R -0.43 -8.05 -0.41 1.56e-14 Colorectal cancer; CRC cis rs6570726 0.818 rs437147 chr6:145875423 A/T cg13319975 chr6:146136371 FBXO30 -0.46 -6.76 -0.35 6.26e-11 Lobe attachment (rater-scored or self-reported); CRC cis rs473651 0.935 rs1103770 chr2:239339281 G/C cg08773314 chr2:239334832 ASB1 0.37 7.76 0.39 1.11e-13 Multiple system atrophy; CRC cis rs35306767 0.761 rs1871621 chr10:1049596 C/T cg26597838 chr10:835615 NA 0.95 11.2 0.53 6.98e-25 Eosinophil percentage of granulocytes; CRC cis rs4363385 0.747 rs1055935 chr1:152975941 C/G cg25856811 chr1:152973957 SPRR3 -0.26 -7.24 -0.37 3.22e-12 Inflammatory skin disease; CRC cis rs422249 0.547 rs174535 chr11:61551356 T/C cg06781209 chr11:61594997 FADS2 -0.39 -5.86 -0.31 1.15e-8 Trans fatty acid levels; CRC cis rs853679 0.517 rs9393898 chr6:28130376 G/T cg12963246 chr6:28129442 ZNF389 0.5 5.75 0.3 2e-8 Depression; CRC cis rs7666738 1.000 rs13144055 chr4:99026849 A/G cg03676636 chr4:99064102 C4orf37 0.25 6.92 0.36 2.44e-11 Colonoscopy-negative controls vs population controls; CRC cis rs116095464 0.614 rs62344339 chr5:252995 T/G cg22857025 chr5:266934 NA -1.25 -16.78 -0.68 4.42e-46 Breast cancer; CRC cis rs28830936 0.510 rs11858843 chr15:42092915 C/A cg17847044 chr15:42102381 MAPKBP1 -0.37 -9.0 -0.44 1.81e-17 Diastolic blood pressure; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg17559213 chr10:80827237 LOC283050 0.42 6.36 0.33 6.64e-10 Intelligence (multi-trait analysis); CRC cis rs524281 0.861 rs7124165 chr11:65901218 C/T cg16950941 chr11:66035639 RAB1B -0.61 -7.52 -0.38 5.31e-13 Electroencephalogram traits; CRC cis rs10242455 1.000 rs73395557 chr7:98934424 C/A cg18809830 chr7:99032528 PTCD1 -0.75 -6.5 -0.34 2.96e-10 Blood metabolite levels; CRC cis rs6709815 0.841 rs12694442 chr2:219663599 T/C cg02176678 chr2:219576539 TTLL4 -0.37 -5.97 -0.31 6.22e-9 Reticulocyte count;High light scatter reticulocyte count; CRC trans rs11764590 0.756 rs17132130 chr7:2108036 G/C cg11693508 chr17:37793320 STARD3 0.51 6.57 0.34 1.93e-10 Neuroticism; CRC cis rs6696846 0.729 rs72757512 chr1:205079203 G/A cg00857998 chr1:205179979 DSTYK 0.45 6.26 0.33 1.2e-9 Red blood cell count; CRC cis rs55665837 1.000 rs7945167 chr11:14451820 T/G cg19336497 chr11:14380999 RRAS2 -0.39 -6.64 -0.34 1.3100000000000001e-10 Vitamin D levels; CRC cis rs12887734 0.524 rs12588797 chr14:104300020 C/T cg08213375 chr14:104286397 PPP1R13B -0.51 -8.78 -0.44 8.95e-17 Schizophrenia;Autism spectrum disorder or schizophrenia; CRC cis rs4642101 0.597 rs9839768 chr3:12821403 C/T cg24848339 chr3:12840334 CAND2 0.34 6.35 0.33 6.98e-10 QRS complex (12-leadsum); CRC cis rs6952808 0.609 rs6944877 chr7:1952582 T/G cg14004847 chr7:1930337 MAD1L1 -0.4 -5.88 -0.31 1.03e-8 Bipolar disorder and schizophrenia; CRC cis rs6502050 0.764 rs35713597 chr17:80119016 C/G cg13198984 chr17:80129470 CCDC57 0.47 8.35 0.42 1.88e-15 Life satisfaction; CRC cis rs10504229 1.000 rs67039591 chr8:58174553 T/A cg02290350 chr8:58132656 NA -0.42 -5.96 -0.31 6.62e-9 Developmental language disorder (linguistic errors); CRC cis rs9910055 0.762 rs11080007 chr17:42265442 A/G cg19774624 chr17:42201019 HDAC5 0.66 9.62 0.47 1.77e-19 Total body bone mineral density; CRC trans rs6693295 0.729 rs12022431 chr1:246216636 A/T cg03680032 chr11:94965610 SESN3 0.49 6.12 0.32 2.68e-9 Migraine - clinic-based;Migraine with aura; CRC cis rs4680 0.737 rs4646312 chr22:19948337 C/T cg01335087 chr22:19950166 COMT 0.21 5.69 0.3 2.75e-8 Blood metabolite levels; CRC cis rs7605827 0.930 rs7593184 chr2:15598461 T/G cg19274914 chr2:15703543 NA 0.4 5.97 0.31 6.3e-9 Educational attainment (years of education); CRC cis rs4713118 0.869 rs6922574 chr6:27693003 A/T cg02683197 chr6:28174875 NA 0.59 7.88 0.4 4.83e-14 Parkinson's disease; CRC cis rs4253772 0.591 rs6008384 chr22:46655948 T/C cg09491104 chr22:46646882 C22orf40 -0.48 -7.52 -0.38 5.38e-13 LDL cholesterol;Cholesterol, total; CRC cis rs45544231 0.569 rs1420530 chr16:52558729 C/T cg09051775 chr16:52580266 TOX3 -0.38 -6.09 -0.32 3.13e-9 Restless legs syndrome; CRC cis rs12711979 0.584 rs11694096 chr2:3868113 G/A cg17052675 chr2:3827356 NA -0.77 -17.11 -0.69 2.18e-47 Itch intensity from mosquito bite adjusted by bite size; CRC cis rs6502050 0.799 rs34795957 chr17:80118013 G/A cg25804541 chr17:80189381 SLC16A3 -0.31 -5.98 -0.31 5.73e-9 Life satisfaction; CRC cis rs8072100 0.713 rs4968228 chr17:45497548 T/C cg08085267 chr17:45401833 C17orf57 -0.56 -8.49 -0.42 7.04e-16 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs6424115 0.729 rs1737362 chr1:24054800 T/C cg10978503 chr1:24200527 CNR2 0.46 7.72 0.39 1.43e-13 Immature fraction of reticulocytes; CRC cis rs3106136 0.872 rs2016476 chr4:95229004 G/A cg11021082 chr4:95130006 SMARCAD1 -0.44 -6.73 -0.35 7.49e-11 Capecitabine sensitivity; CRC cis rs2882667 0.858 rs13170388 chr5:138436865 A/G cg09476006 chr5:138032270 NA 0.44 6.74 0.35 6.92e-11 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs62229266 0.771 rs7277791 chr21:37383227 C/A cg08632701 chr21:37451849 NA -0.42 -6.64 -0.34 1.27e-10 Mitral valve prolapse; CRC cis rs7666738 0.752 rs62318905 chr4:99036103 T/G cg17366294 chr4:99064904 C4orf37 0.43 7.15 0.37 5.77e-12 Colonoscopy-negative controls vs population controls; CRC trans rs925098 0.577 rs2724470 chr4:17996046 A/G cg07030052 chr1:162531143 UAP1 -0.41 -6.26 -0.33 1.18e-9 Birth weight;Height; CRC cis rs929354 0.685 rs7807856 chr7:156934498 T/C cg17757837 chr7:157058334 UBE3C 0.74 12.39 0.56 3.31e-29 Body mass index; CRC cis rs2073499 0.810 rs78501918 chr3:50369914 A/G cg09545109 chr3:50388910 TUSC4;CYB561D2 0.63 5.71 0.3 2.48e-8 Schizophrenia; CRC cis rs9488822 0.702 rs12196154 chr6:116327471 T/G cg05304507 chr6:116381966 FRK 0.3 8.24 0.41 4.08e-15 Cholesterol, total;LDL cholesterol; CRC cis rs6988636 1.000 rs28513831 chr8:124189208 T/C cg27053337 chr8:124217698 FAM83A 0.46 6.99 0.36 1.58e-11 Urinary uromodulin levels; CRC cis rs11723261 0.582 rs11732336 chr4:140512 A/G cg12746427 chr4:53362 ZNF718;ZNF595 0.46 6.09 0.32 3.11e-9 Immune response to smallpox vaccine (IL-6); CRC cis rs703842 1.000 rs10877013 chr12:58165085 C/T cg00677455 chr12:58241039 CTDSP2 0.68 9.68 0.47 1.19e-19 Multiple sclerosis; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg12677436 chr2:54785476 SPTBN1 0.43 5.96 0.31 6.42e-9 Response to antipsychotic treatment; CRC cis rs7945705 0.692 rs11042149 chr11:9010737 T/C cg00186954 chr11:8933980 ST5;C11orf17 -0.45 -7.66 -0.39 2.12e-13 Hemoglobin concentration; CRC cis rs7666738 0.830 rs7698771 chr4:98986479 T/G cg17366294 chr4:99064904 C4orf37 0.43 7.33 0.37 1.76e-12 Colonoscopy-negative controls vs population controls; CRC cis rs4665809 0.590 rs72809668 chr2:26467653 C/T cg04944784 chr2:26401820 FAM59B 0.83 10.74 0.51 2.96e-23 Gut microbiome composition (summer); CRC trans rs9914544 0.545 rs8073436 chr17:18801841 A/G cg21372672 chr17:16614065 CCDC144A -0.38 -6.0 -0.31 5.11e-9 Educational attainment (years of education); CRC cis rs425277 0.606 rs2459984 chr1:2086312 A/G cg21194808 chr1:2205498 SKI 0.38 5.95 0.31 6.8e-9 Height; CRC cis rs7953508 0.711 rs11107117 chr12:93979419 T/C cg18151635 chr12:93972918 NA -0.73 -9.92 -0.48 1.8899999999999998e-20 Pubertal anthropometrics; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg07466433 chr2:7005728 CMPK2 0.39 6.2 0.32 1.73e-9 Liver disease severity in Alagille syndrome; CRC cis rs4727027 0.727 rs3801980 chr7:148878620 T/A cg12479418 chr7:148823350 ZNF425;ZNF398 0.5 6.62 0.34 1.47e-10 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg23681243 chr15:25684088 UBE3A 0.45 6.37 0.33 6.55e-10 Response to antipsychotic treatment; CRC cis rs7760949 0.889 rs9396272 chr6:13938080 C/T cg27413430 chr6:13925136 RNF182 -0.34 -5.95 -0.31 6.69e-9 Mean corpuscular hemoglobin concentration; CRC cis rs4803468 1.000 rs10413735 chr19:41921071 C/T cg09537434 chr19:41945824 ATP5SL -0.97 -18.77 -0.72 5.95e-54 Height; CRC cis rs2013441 0.804 rs1811453 chr17:20232193 A/C cg13482628 chr17:19912719 NA -0.41 -6.3 -0.33 9.69e-10 Obesity-related traits; CRC cis rs477692 1.000 rs508303 chr10:131424996 A/T cg05714579 chr10:131428358 MGMT -0.52 -7.58 -0.39 3.46e-13 Response to temozolomide; CRC cis rs875971 0.545 rs12670811 chr7:65823019 C/A cg05627663 chr7:65219948 SNORA22;CCT6P1 0.56 7.23 0.37 3.38e-12 Aortic root size; CRC cis rs1401999 0.934 rs1132776 chr3:183696402 A/G cg05044414 chr3:183734942 ABCC5 0.44 7.76 0.39 1.06e-13 Anterior chamber depth; CRC cis rs7618915 0.501 rs2109634 chr3:52752075 T/G cg05573699 chr3:52720067 GNL3;PBRM1 -0.48 -6.95 -0.36 2.01e-11 Bipolar disorder; CRC cis rs3806843 0.932 rs2563269 chr5:140136468 G/T cg16607685 chr5:140181889 PCDHA2;PCDHA1;PCDHA3 0.26 6.02 0.32 4.63e-9 Depressive symptoms (multi-trait analysis); CRC cis rs35306767 0.714 rs28512382 chr10:1092195 G/C cg20503657 chr10:835505 NA 0.83 9.88 0.48 2.57e-20 Eosinophil percentage of granulocytes; CRC cis rs7208859 0.524 rs59923796 chr17:29064919 G/A cg13385521 chr17:29058706 SUZ12P 0.71 8.01 0.4 1.98e-14 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs7772486 0.754 rs2064185 chr6:146066814 G/A cg05347473 chr6:146136440 FBXO30 -0.39 -5.85 -0.31 1.16e-8 Lobe attachment (rater-scored or self-reported); CRC cis rs854765 0.964 rs2230316 chr17:17997209 C/T cg04398451 chr17:18023971 MYO15A 0.5 8.08 0.41 1.22e-14 Total body bone mineral density; CRC cis rs1223397 0.651 rs2439543 chr6:13312153 A/C cg20827128 chr6:13274284 PHACTR1 0.38 5.81 0.3 1.5e-8 Blood pressure; CRC trans rs1005277 0.565 rs2474565 chr10:38380828 A/G cg17830980 chr10:43048298 ZNF37B -0.6 -9.98 -0.48 1.19e-20 Extrinsic epigenetic age acceleration; CRC cis rs7633770 0.786 rs950190 chr3:46683377 C/T cg11219411 chr3:46661640 NA 0.54 8.61 0.43 3.01e-16 Coronary artery disease; CRC cis rs2070488 0.775 rs7374458 chr3:38531211 T/G cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.82 14.29 0.62 2.28e-36 Electrocardiographic conduction measures; CRC cis rs7113874 0.569 rs2871753 chr11:8486650 A/T cg17679104 chr11:8615758 STK33 0.35 5.74 0.3 2.17e-8 Body mass index in physically active individuals;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs9649465 0.967 rs11769381 chr7:123264804 C/T cg03229431 chr7:123269106 ASB15 -0.4 -6.01 -0.31 4.86e-9 Migraine; CRC cis rs68170813 0.559 rs17427123 chr7:106823661 G/A cg02696742 chr7:106810147 HBP1 -0.64 -7.2 -0.37 4.19e-12 Coronary artery disease; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg20809690 chr4:2757764 TNIP2 0.39 6.08 0.32 3.32e-9 Liver disease severity in Alagille syndrome; CRC cis rs7618501 0.521 rs11709573 chr3:49956628 C/T cg05623727 chr3:50126028 RBM5 0.61 10.52 0.5 1.62e-22 Intelligence (multi-trait analysis); CRC cis rs10411161 0.579 rs59305384 chr19:52387064 A/G cg11269599 chr19:52391304 ZNF577 0.44 5.65 0.3 3.48e-8 Breast cancer; CRC cis rs2797160 0.905 rs1418641 chr6:125999854 C/T cg05901451 chr6:126070800 HEY2 -0.38 -5.93 -0.31 7.46e-9 Endometrial cancer; CRC cis rs977987 0.931 rs8057084 chr16:75492706 G/T cg03315344 chr16:75512273 CHST6 -0.62 -10.8 -0.51 1.82e-23 Dupuytren's disease; CRC cis rs7615952 0.641 rs7618515 chr3:125790578 C/T cg18479299 chr3:125709523 NA -0.55 -6.63 -0.34 1.4e-10 Blood pressure (smoking interaction); CRC cis rs7618915 0.508 rs7628578 chr3:52628321 A/T cg18099408 chr3:52552593 STAB1 -0.47 -7.95 -0.4 3.03e-14 Bipolar disorder; CRC cis rs28386778 0.897 rs3785572 chr17:61829989 C/T cg06873352 chr17:61820015 STRADA 0.76 14.29 0.62 2.25e-36 Prudent dietary pattern; CRC cis rs9914988 0.832 rs12946132 chr17:27157362 T/C cg12682573 chr17:27188876 MIR451;MIR144 0.57 7.99 0.4 2.37e-14 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC trans rs1455244 0.700 rs7229302 chr18:11508904 G/T cg07400628 chr1:6761934 DNAJC11 0.39 6.03 0.32 4.51e-9 Schizophrenia; CRC cis rs7692995 1.000 rs6449346 chr4:17934461 T/C cg08925142 chr4:18023851 LCORL -0.52 -5.85 -0.31 1.21e-8 Height; CRC cis rs7726839 0.540 rs11750321 chr5:599196 C/T cg16447950 chr5:562315 NA -0.74 -9.79 -0.47 4.96e-20 Obesity-related traits; CRC cis rs832540 1.000 rs192249 chr5:56197514 C/G cg12311346 chr5:56204834 C5orf35 -0.46 -7.1 -0.36 7.51e-12 Coronary artery disease; CRC cis rs2456568 0.867 rs7114457 chr11:93657817 C/T cg26875233 chr11:93583750 C11orf90 -0.31 -5.94 -0.31 7.38e-9 Response to serotonin reuptake inhibitors in major depressive disorder; CRC cis rs2274273 1.000 rs7160110 chr14:55594635 A/G cg23234261 chr14:55582407 NA -0.3 -5.92 -0.31 8.14e-9 Protein biomarker; CRC cis rs1552244 1.000 rs7637888 chr3:10080722 T/C cg00166722 chr3:10149974 C3orf24 0.71 9.49 0.46 4.86e-19 Alzheimer's disease; CRC cis rs2836974 0.644 rs11088471 chr21:40699313 A/G cg22974920 chr21:40686053 BRWD1 -0.42 -5.65 -0.3 3.45e-8 Cognitive function; CRC cis rs10493773 0.609 rs11161664 chr1:86185379 C/T cg23216685 chr1:86174607 ZNHIT6 -0.29 -6.71 -0.35 8.57e-11 Urate levels in overweight individuals; CRC cis rs1878931 0.520 rs12447807 chr16:3413896 A/G cg26668626 chr16:3451006 ZNF174;ZNF434 0.95 16.1 0.66 1.97e-43 Body mass index (adult); CRC cis rs2243480 1.000 rs186378 chr7:65582058 A/C cg18252515 chr7:66147081 NA -1.18 -13.88 -0.61 8.21e-35 Diabetic kidney disease; CRC cis rs73206853 0.764 rs56205958 chr12:111027361 G/C cg12870014 chr12:110450643 ANKRD13A 0.8 9.18 0.45 5.09e-18 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC cis rs1129187 0.755 rs28868299 chr6:42921221 T/G cg03790207 chr6:42947109 PEX6 -0.49 -6.91 -0.36 2.51e-11 Alzheimer's disease in APOE e4+ carriers; CRC cis rs12580194 1.000 rs60206376 chr12:55703375 C/A cg19537932 chr12:55886519 OR6C68 -0.57 -7.02 -0.36 1.31e-11 Cancer; CRC cis rs6831352 0.918 rs13112176 chr4:100055825 G/A cg12011299 chr4:100065546 ADH4 -0.49 -9.27 -0.45 2.61e-18 Alcohol dependence; CRC cis rs1153858 0.943 rs8038342 chr15:45651537 T/C cg21132104 chr15:45694354 SPATA5L1 0.6 8.87 0.44 4.85e-17 Homoarginine levels; CRC cis rs6460942 0.915 rs6968695 chr7:12443878 G/C cg20607287 chr7:12443886 VWDE -0.68 -7.35 -0.38 1.59e-12 Coronary artery disease; CRC cis rs7493 0.950 rs56265549 chr7:95047155 G/A cg07404485 chr7:94953653 PON1 -0.45 -5.94 -0.31 7.43e-9 Yu-Zhi constitution type in type 2 diabetes; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg22075671 chr5:133747798 CDKN2AIPNL 0.4 6.05 0.32 3.92e-9 Intelligence (multi-trait analysis); CRC cis rs1129187 0.755 rs9471988 chr6:42944773 T/C cg10862848 chr6:42927986 GNMT -0.39 -9.12 -0.45 7.84e-18 Alzheimer's disease in APOE e4+ carriers; CRC cis rs11148252 0.557 rs9536223 chr13:53233194 A/T cg00495681 chr13:53174319 NA 0.85 15.52 0.65 3.75e-41 Lewy body disease; CRC cis rs4722166 0.695 rs4722177 chr7:22798531 T/C cg05472934 chr7:22766657 IL6 0.67 10.86 0.51 1.14e-23 Lung cancer; CRC cis rs11758351 0.866 rs2022448 chr6:26207928 C/T cg08260959 chr6:26240920 HIST1H4F -0.32 -5.8 -0.3 1.53e-8 Gout;Renal underexcretion gout; CRC cis rs7584330 0.541 rs10202181 chr2:238352099 A/G cg11271282 chr2:238384023 NA 0.45 5.7 0.3 2.72e-8 Prostate cancer; CRC cis rs2739330 0.828 rs2154593 chr22:24252085 A/G cg10819733 chr22:24237672 NA -0.35 -5.92 -0.31 8.17e-9 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs4665809 1.000 rs750451 chr2:26324241 G/A cg27170947 chr2:26402098 FAM59B -0.46 -6.1 -0.32 2.93e-9 Gut microbiome composition (summer); CRC cis rs7119 0.717 rs11636412 chr15:77767291 C/T cg17802220 chr15:77601643 NA -0.46 -6.57 -0.34 1.99e-10 Type 2 diabetes; CRC cis rs6952808 0.825 rs11761818 chr7:1935273 C/T cg21782813 chr7:2030301 MAD1L1 0.46 8.0 0.4 2.09e-14 Bipolar disorder and schizophrenia; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg13378284 chr11:616089 IRF7 0.46 7.62 0.39 2.82e-13 Liver disease severity in Alagille syndrome; CRC cis rs2836974 0.897 rs13339986 chr21:40605982 T/C cg17971929 chr21:40555470 PSMG1 0.74 10.02 0.48 8.29e-21 Cognitive function; CRC cis rs8060686 0.563 rs118005841 chr16:68157562 A/T cg26727032 chr16:67993705 SLC12A4 -0.54 -6.13 -0.32 2.49e-9 HDL cholesterol;Metabolic syndrome; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg12528403 chr1:40997196 ZNF684 0.4 6.27 0.33 1.14e-9 Liver disease severity in Alagille syndrome; CRC cis rs6088580 0.634 rs1205344 chr20:32918298 G/A cg24642439 chr20:33292090 TP53INP2 -0.42 -6.9 -0.36 2.68e-11 Glomerular filtration rate (creatinine); CRC cis rs59104589 0.521 rs3771584 chr2:242399493 C/G cg19488206 chr2:242435732 STK25 0.47 7.51 0.38 5.68e-13 Fibrinogen levels; CRC cis rs73198271 0.531 rs3827812 chr8:8654898 C/T cg01851573 chr8:8652454 MFHAS1 0.52 6.38 0.33 6.13e-10 Bone ultrasound measurement (broadband ultrasound attenuation); CRC cis rs6502050 0.799 rs4789674 chr17:80123200 G/A cg02741985 chr17:80059408 CCDC57 0.43 7.16 0.37 5.47e-12 Life satisfaction; CRC cis rs12024301 0.557 rs10911390 chr1:183616884 C/T cg11505048 chr1:183622726 RGL1;APOBEC4 0.81 7.0 0.36 1.42e-11 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs2302190 0.882 rs7226008 chr17:56644633 T/C cg12560992 chr17:57184187 TRIM37 0.53 6.15 0.32 2.28e-9 Vitamin D levels; CRC cis rs2933343 0.951 rs1055128 chr3:128591048 C/T cg11901034 chr3:128598214 ACAD9 -0.5 -6.12 -0.32 2.64e-9 IgG glycosylation; CRC cis rs6500395 0.962 rs9921741 chr16:48589896 G/A cg04672837 chr16:48644449 N4BP1 0.42 5.99 0.31 5.43e-9 Response to tocilizumab in rheumatoid arthritis; CRC cis rs400736 0.930 rs226251 chr1:8024690 T/C cg25007680 chr1:8021821 PARK7 0.56 7.6 0.39 3.06e-13 Response to antidepressants and depression; CRC cis rs17401966 0.838 rs2105212 chr1:10281012 T/C cg19773385 chr1:10388646 KIF1B -0.62 -9.88 -0.48 2.48e-20 Hepatocellular carcinoma; CRC trans rs8002861 0.846 rs12869521 chr13:44478346 A/G cg17145862 chr1:211918768 LPGAT1 -0.69 -12.38 -0.56 3.63e-29 Leprosy; CRC trans rs1005277 0.602 rs1831315 chr10:38473353 T/C cg27523141 chr10:43048294 ZNF37B 0.45 6.37 0.33 6.19e-10 Extrinsic epigenetic age acceleration; CRC cis rs3820068 0.581 rs72645877 chr1:15928106 G/T cg27534772 chr1:16042836 PLEKHM2 0.54 10.46 0.5 2.7e-22 Systolic blood pressure; CRC cis rs10078 0.515 rs1053299 chr5:470760 G/A cg26072250 chr5:443457 EXOC3;C5orf55 0.58 5.73 0.3 2.25e-8 Fat distribution (HIV); CRC trans rs10504229 1.000 rs55787104 chr8:58178519 C/T cg04077850 chr5:125800366 GRAMD3 0.36 6.11 0.32 2.89e-9 Developmental language disorder (linguistic errors); CRC cis rs870825 0.616 rs28673855 chr4:185627416 T/G cg04058563 chr4:185651563 MLF1IP 0.72 9.38 0.46 1.12e-18 Blood protein levels; CRC cis rs7772486 0.719 rs702317 chr6:146005010 C/T cg05347473 chr6:146136440 FBXO30 -0.4 -5.99 -0.31 5.62e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs597539 0.690 rs552517 chr11:68625286 T/G cg21963583 chr11:68658836 MRPL21 0.59 10.38 0.5 5.06e-22 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs78472555 0.789 rs2603229 chr15:100263499 T/C cg18869061 chr15:100272053 LYSMD4 0.48 6.62 0.34 1.48e-10 Post bronchodilator FEV1/FVC ratio in COPD; CRC trans rs7615952 0.599 rs7631268 chr3:125755664 T/A cg07211511 chr3:129823064 LOC729375 -0.77 -10.24 -0.49 1.47e-21 Blood pressure (smoking interaction); CRC cis rs6121246 0.609 rs6060955 chr20:30385071 A/G cg18721089 chr20:30220636 NA -0.32 -5.78 -0.3 1.69e-8 Mean corpuscular hemoglobin; CRC cis rs12745968 0.589 rs10874711 chr1:93017988 C/T cg17283838 chr1:93427260 FAM69A -0.48 -6.36 -0.33 6.91e-10 Bipolar disorder and schizophrenia; CRC cis rs1150668 0.699 rs1736895 chr6:28219826 G/A cg06470822 chr6:28175283 NA 0.54 8.08 0.41 1.24e-14 Pubertal anthropometrics; CRC cis rs2070997 0.702 rs7021981 chr9:133739735 G/T cg01000188 chr9:133769184 QRFP 0.65 7.17 0.37 5.08e-12 Response to amphetamines; CRC cis rs7809950 1.000 rs67982599 chr7:107100104 T/G cg23024343 chr7:107201750 COG5 -0.59 -8.6 -0.43 3.28e-16 Coronary artery disease; CRC cis rs11677416 0.961 rs1894399 chr2:113540177 C/T cg27083787 chr2:113543245 IL1A 0.44 6.24 0.33 1.32e-9 Response to antipsychotic treatment in schizophrenia (working memory); CRC cis rs1005277 0.579 rs2505196 chr10:38393563 G/A cg25517755 chr10:38738941 LOC399744 -0.44 -6.41 -0.33 5.05e-10 Extrinsic epigenetic age acceleration; CRC cis rs17401966 0.593 rs11121523 chr1:10214442 T/A cg19773385 chr1:10388646 KIF1B -0.47 -6.4 -0.33 5.48e-10 Hepatocellular carcinoma; CRC cis rs4604732 0.588 rs7549955 chr1:247628321 G/A cg12758973 chr1:247694275 LOC148824;OR2C3 0.38 5.75 0.3 2.03e-8 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CRC cis rs6604026 0.922 rs34244251 chr1:93297180 G/A cg17283838 chr1:93427260 FAM69A 0.44 5.62 0.3 4.13e-8 Multiple sclerosis; CRC cis rs7666738 0.791 rs13125277 chr4:99009922 T/G cg05340658 chr4:99064831 C4orf37 0.61 9.54 0.47 3.44e-19 Colonoscopy-negative controls vs population controls; CRC cis rs1153858 1.000 rs2114501 chr15:45670316 G/A cg10760299 chr15:45669010 GATM 0.49 7.65 0.39 2.19e-13 Homoarginine levels; CRC cis rs8060686 0.858 rs6499143 chr16:67874264 T/C cg00318322 chr16:67708822 GFOD2 -0.31 -5.84 -0.31 1.23e-8 HDL cholesterol;Metabolic syndrome; CRC cis rs6503525 0.591 rs8080734 chr17:38103285 G/A cg17344932 chr17:38183730 MED24;SNORD124 -0.46 -7.49 -0.38 6.35e-13 Asthma; CRC cis rs7703744 0.681 rs17145294 chr5:118701433 G/T cg23917399 chr5:118691751 TNFAIP8 0.42 5.87 0.31 1.09e-8 Lobe attachment (rater-scored or self-reported); CRC cis rs16975963 0.644 rs12459013 chr19:38129497 C/G cg15135657 chr19:38346511 NA -0.47 -6.34 -0.33 7.4e-10 Longevity; CRC cis rs10256972 0.630 rs13235747 chr7:1129123 T/C cg09177884 chr7:1199841 ZFAND2A -0.4 -5.68 -0.3 2.95e-8 Longevity;Endometriosis; CRC cis rs6502050 0.835 rs12945993 chr17:80129485 T/C cg19223190 chr17:80058835 NA 0.39 6.25 0.33 1.3e-9 Life satisfaction; CRC cis rs10464366 0.544 rs6952466 chr7:39155032 A/T cg20302533 chr7:39170763 POU6F2 0.43 6.08 0.32 3.26e-9 IgG glycosylation; CRC cis rs1129187 0.967 rs9462857 chr6:42943098 T/C cg03790207 chr6:42947109 PEX6 -0.44 -6.26 -0.33 1.22e-9 Alzheimer's disease in APOE e4+ carriers; CRC cis rs2839186 0.771 rs2280959 chr21:47641996 C/G cg05896524 chr21:47604654 C21orf56 0.47 7.15 0.37 5.74e-12 Testicular germ cell tumor; CRC cis rs7927592 0.913 rs10896330 chr11:68254998 A/G cg16797656 chr11:68205561 LRP5 0.39 6.24 0.33 1.36e-9 Total body bone mineral density; CRC cis rs7953508 0.506 rs10859532 chr12:93960917 G/C cg18151635 chr12:93972918 NA -0.81 -11.64 -0.54 1.78e-26 Pubertal anthropometrics; CRC cis rs2032447 0.832 rs10425 chr6:26056549 A/G cg12310025 chr6:25882481 NA -0.47 -6.68 -0.35 9.96e-11 Intelligence (multi-trait analysis); CRC cis rs9611565 0.512 rs9611667 chr22:42187015 C/T cg06634786 chr22:41940651 POLR3H -0.69 -7.61 -0.39 2.84e-13 Vitiligo; CRC cis rs28386778 0.897 rs9912557 chr17:61784963 C/A cg06873352 chr17:61820015 STRADA 0.78 14.66 0.63 8.44e-38 Prudent dietary pattern; CRC cis rs2072510 0.569 rs61937880 chr12:96390867 C/A cg15438951 chr12:96389694 HAL -0.48 -5.84 -0.31 1.22e-8 Metabolite levels (small molecules and protein measures); CRC cis rs28386778 0.863 rs3760256 chr17:61821161 A/G cg22520471 chr17:61851767 DDX42;CCDC47 0.74 11.56 0.54 3.69e-26 Prudent dietary pattern; CRC cis rs6921919 0.583 rs9468367 chr6:28360246 C/A cg21251018 chr6:28226885 NKAPL 0.4 6.07 0.32 3.61e-9 Autism spectrum disorder or schizophrenia; CRC cis rs4535497 0.525 rs4975639 chr5:1108250 A/G cg18655438 chr5:1077845 SLC12A7 0.46 6.67 0.35 1.08e-10 Mean corpuscular hemoglobin concentration; CRC trans rs925098 0.577 rs2724470 chr4:17996046 A/G cg08206623 chr11:2907334 CDKN1C -0.41 -6.27 -0.33 1.12e-9 Birth weight;Height; CRC cis rs9409565 0.826 rs639276 chr9:97206737 G/T cg04523069 chr9:97136363 HIATL1 0.37 5.67 0.3 3.05e-8 Colorectal cancer (alcohol consumption interaction); CRC cis rs7727544 0.654 rs4705849 chr5:131559199 T/A cg11843238 chr5:131593191 PDLIM4 0.36 6.62 0.34 1.49e-10 Blood metabolite levels; CRC cis rs3768617 0.528 rs6672093 chr1:183079853 T/C ch.1.3577855R chr1:183094577 LAMC1 0.89 15.73 0.66 5.66e-42 Fuchs's corneal dystrophy; CRC cis rs995000 0.899 rs7518497 chr1:63177696 G/T cg19896129 chr1:63156450 NA -0.4 -5.75 -0.3 2.01e-8 Triglyceride levels; CRC cis rs6089584 0.853 rs1746280 chr20:60577821 C/G cg06108461 chr20:60628389 TAF4 -0.79 -12.14 -0.56 2.88e-28 Body mass index; CRC cis rs4555082 0.756 rs76863138 chr14:105736379 C/T cg10792982 chr14:105748885 BRF1 0.38 6.29 0.33 9.84e-10 Mean platelet volume;Platelet distribution width; CRC cis rs3018066 0.867 rs3113250 chr4:107207049 G/A cg01869342 chr4:106983673 TBCK 0.37 5.79 0.3 1.61e-8 Cancer; CRC cis rs9486719 0.947 rs2472908 chr6:96875998 A/T cg06623918 chr6:96969491 KIAA0776 0.81 9.54 0.47 3.36e-19 Migraine;Coronary artery disease; CRC cis rs6465657 0.903 rs11767962 chr7:97778576 C/T cg24562669 chr7:97807699 LMTK2 0.79 17.7 0.7 1.05e-49 Prostate cancer (SNP x SNP interaction);Prostate cancer; CRC cis rs1448094 0.511 rs61930074 chr12:86218759 G/C cg19622623 chr12:86230825 RASSF9 -0.37 -5.95 -0.31 7.02e-9 Major depressive disorder; CRC cis rs1816752 0.905 rs9581026 chr13:24997926 C/A cg02811702 chr13:24901961 NA 0.43 5.97 0.31 5.99e-9 Obesity-related traits; CRC cis rs478304 0.900 rs502468 chr11:65525119 T/G cg27068330 chr11:65405492 SIPA1 0.48 7.0 0.36 1.45e-11 Acne (severe); CRC cis rs7112925 1.000 rs7112925 chr11:66826160 C/T cg24851651 chr11:66362959 CCS -0.38 -6.43 -0.33 4.57e-10 Height; CRC cis rs8180040 0.652 rs13077398 chr3:47011120 G/C cg27129171 chr3:47204927 SETD2 0.65 10.29 0.49 9.94e-22 Colorectal cancer; CRC cis rs13108904 0.521 rs4974609 chr4:1356924 A/C cg15763984 chr4:1342303 KIAA1530 -0.46 -8.27 -0.41 3.44e-15 Obesity-related traits; CRC cis rs8141529 0.748 rs5762881 chr22:29289346 C/A cg02153584 chr22:29168773 CCDC117 0.48 6.9 0.36 2.75e-11 Lymphocyte counts; CRC cis rs9549367 0.713 rs9549357 chr13:113860121 C/T cg18105134 chr13:113819100 PROZ -0.85 -11.77 -0.54 6.07e-27 Platelet distribution width; CRC cis rs8044995 0.563 rs56899435 chr16:68395675 G/A cg05110241 chr16:68378359 PRMT7 -0.75 -7.78 -0.39 9.72e-14 Schizophrenia; CRC cis rs2836974 0.899 rs2836957 chr21:40623134 T/C cg06238570 chr21:40685208 BRWD1 0.79 10.84 0.51 1.29e-23 Cognitive function; CRC cis rs12701220 0.655 rs7784403 chr7:1153077 G/A cg26769984 chr7:1090371 C7orf50 0.56 7.69 0.39 1.68e-13 Bronchopulmonary dysplasia; CRC cis rs8141797 0.901 rs5760201 chr22:24474704 A/G cg20894457 chr22:24584366 SUSD2 0.63 7.58 0.39 3.55e-13 Amyotrophic lateral sclerosis;Coronary artery disease; CRC cis rs7677751 0.806 rs890203 chr4:55097405 A/C cg17187183 chr4:55093834 PDGFRA 0.52 7.37 0.38 1.36e-12 Corneal astigmatism; CRC cis rs1215050 0.791 rs165242 chr4:98686482 A/C cg05340658 chr4:99064831 C4orf37 -0.41 -5.72 -0.3 2.36e-8 Waist-to-hip ratio adjusted for body mass index; CRC cis rs9910055 0.676 rs11079983 chr17:42198170 C/T cg19774624 chr17:42201019 HDAC5 -0.6 -8.58 -0.43 3.93e-16 Total body bone mineral density; CRC cis rs1862618 0.671 rs173763 chr5:56225418 G/A cg03609598 chr5:56110824 MAP3K1 -0.59 -7.88 -0.4 4.77e-14 Initial pursuit acceleration; CRC cis rs9462027 0.628 rs6925623 chr6:34800896 A/G cg07306190 chr6:34760872 UHRF1BP1 -0.34 -6.09 -0.32 3.16e-9 Systemic lupus erythematosus; CRC cis rs55788414 0.932 rs9936302 chr16:81190790 C/T cg06400318 chr16:81190750 PKD1L2 -0.62 -6.88 -0.35 3.08e-11 Left ventricular obstructive tract defect (maternal effect); CRC cis rs12594515 0.967 rs67854274 chr15:45990518 A/G cg22117107 chr15:45993392 NA -0.44 -9.09 -0.45 9.56e-18 Waist circumference;Weight; CRC cis rs713587 0.646 rs34697209 chr2:25127394 A/G cg04586622 chr2:25135609 ADCY3 -0.57 -10.96 -0.52 5.04e-24 Body mass index in non-asthmatics; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg26719024 chr10:105156444 PDCD11;USMG5 0.47 6.13 0.32 2.57e-9 Thyroid stimulating hormone; CRC cis rs2777491 0.574 rs316611 chr15:41751678 A/G cg18705301 chr15:41695430 NDUFAF1 1.1 18.95 0.72 1.18e-54 Ulcerative colitis; CRC cis rs8062405 1.000 rs4788095 chr16:28831359 T/C cg08761264 chr16:28874980 SH2B1 -0.42 -5.66 -0.3 3.26e-8 Cognitive ability (multi-trait analysis);Cognitive ability; CRC cis rs6502050 0.835 rs8078087 chr17:80113322 T/G cg25804541 chr17:80189381 SLC16A3 -0.31 -5.97 -0.31 6.08e-9 Life satisfaction; CRC cis rs910316 0.726 rs61979167 chr14:75663610 C/T cg11812906 chr14:75593930 NEK9 -0.47 -6.91 -0.36 2.59e-11 Height; CRC cis rs4731207 0.698 rs4731223 chr7:124483272 A/T cg23710748 chr7:124431027 NA 0.38 6.08 0.32 3.28e-9 Cutaneous malignant melanoma; CRC cis rs3540 0.574 rs2256388 chr15:90969335 A/C cg22089800 chr15:90895588 ZNF774 -0.57 -9.61 -0.47 2.02e-19 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; CRC cis rs3741151 1.000 rs7129663 chr11:73045129 C/T cg17517138 chr11:73019481 ARHGEF17 1.09 9.24 0.45 3.09e-18 GIP levels in response to oral glucose tolerance test (120 minutes); CRC cis rs728616 0.681 rs12412762 chr10:81907470 A/G cg11900509 chr10:81946545 ANXA11 0.78 8.89 0.44 4.08e-17 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs17270561 0.779 rs17271767 chr6:25886921 C/T cg17691542 chr6:26056736 HIST1H1C 0.76 9.94 0.48 1.51e-20 Iron status biomarkers; CRC cis rs875971 1.000 rs6961717 chr7:65587537 C/T cg18912574 chr7:65842487 NCRNA00174 -0.36 -6.2 -0.32 1.68e-9 Aortic root size; CRC cis rs8141529 0.732 rs2347447 chr22:29179739 C/A cg02153584 chr22:29168773 CCDC117 0.54 7.98 0.4 2.39e-14 Lymphocyte counts; CRC cis rs6540559 0.808 rs11119358 chr1:210042456 T/C cg22029157 chr1:209979665 IRF6 0.57 7.08 0.36 8.52e-12 Cleft lip with or without cleft palate; CRC cis rs9905704 0.918 rs304283 chr17:56785725 C/T cg12560992 chr17:57184187 TRIM37 0.53 7.31 0.37 1.99e-12 Testicular germ cell tumor; CRC cis rs26868 0.766 rs26867 chr16:2249410 T/C cg07587117 chr16:2239488 CASKIN1 0.43 7.63 0.39 2.59e-13 Height; CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg20552752 chr15:90895281 ZNF774 -0.5 -6.22 -0.32 1.48e-9 Diisocyanate-induced asthma; CRC cis rs7264396 0.790 rs6060541 chr20:34248066 C/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.61 -10.31 -0.49 8.99e-22 Total cholesterol levels; CRC cis rs806215 0.813 rs2582717 chr7:127311863 A/G cg25922125 chr7:127225783 GCC1 0.49 5.98 0.31 5.92e-9 Type 2 diabetes; CRC cis rs4713118 0.662 rs469228 chr6:27970704 A/G cg06470822 chr6:28175283 NA 0.84 12.77 0.58 1.28e-30 Parkinson's disease; CRC cis rs12477438 0.520 rs1453563 chr2:99720267 C/G cg14399236 chr2:99771627 LIPT1;TSGA10 0.72 12.02 0.55 7.68e-28 Chronic sinus infection; CRC cis rs3018066 0.666 rs7662806 chr4:106997167 C/A cg01869342 chr4:106983673 TBCK 0.48 6.23 0.33 1.39e-9 Cancer; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg02458384 chr16:2021763 TBL3 0.44 7.18 0.37 4.61e-12 Liver disease severity in Alagille syndrome; CRC cis rs11577318 0.853 rs1071849 chr1:26646726 A/G cg04990556 chr1:26633338 UBXN11 -0.46 -5.76 -0.3 1.98e-8 Granulocyte percentage of myeloid white cells; CRC cis rs9443645 0.901 rs3805747 chr6:79672522 A/G cg09184832 chr6:79620586 NA -0.52 -9.44 -0.46 7.16e-19 Intelligence (multi-trait analysis); CRC cis rs6502050 0.740 rs4789748 chr17:80093061 A/C cg22110888 chr17:80059540 CCDC57 0.41 6.46 0.34 3.82e-10 Life satisfaction; CRC cis rs4713118 0.539 rs200988 chr6:27819353 A/C cg21251018 chr6:28226885 NKAPL 0.5 7.66 0.39 2.12e-13 Parkinson's disease; CRC cis rs11650776 1 rs11650776 chr17:37641402 G/A cg03013999 chr17:37608204 MED1 0.43 6.6 0.34 1.68e-10 Lung function (FEV1); CRC cis rs10832963 1.000 rs10832956 chr11:18645668 A/G cg20219074 chr11:18656078 SPTY2D1 0.56 8.13 0.41 8.63e-15 Breast cancer; CRC cis rs9814567 0.806 rs6806810 chr3:134323522 G/A cg06541857 chr3:134203789 ANAPC13;CEP63 -0.37 -5.71 -0.3 2.47e-8 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs870825 0.616 rs28490461 chr4:185651638 C/T cg04058563 chr4:185651563 MLF1IP 0.72 9.28 0.46 2.4e-18 Blood protein levels; CRC trans rs637571 0.676 rs634534 chr11:65665256 A/G cg17712092 chr4:129076599 LARP1B -0.75 -12.36 -0.56 4.56e-29 Eosinophil percentage of white cells; CRC trans rs1814175 0.645 rs10839382 chr11:49823172 C/T cg15704280 chr7:45808275 SEPT13 -0.94 -16.5 -0.67 5.63e-45 Height; CRC cis rs6564851 0.506 rs11641417 chr16:81257783 G/A cg05274606 chr16:81253692 PKD1L2 -0.38 -6.16 -0.32 2.15e-9 Carotenoid and tocopherol levels; CRC cis rs4665809 0.838 rs6546749 chr2:26306288 T/C cg26119090 chr2:26468346 HADHA;HADHB -0.67 -8.29 -0.42 2.95e-15 Gut microbiome composition (summer); CRC cis rs4713118 0.586 rs9468290 chr6:28087674 C/T cg06470822 chr6:28175283 NA 1.0 13.06 0.58 1.06e-31 Parkinson's disease; CRC cis rs11711311 1.000 rs10934243 chr3:113430239 T/A cg15478005 chr3:113465772 ATP6V1A;NAA50 0.44 6.02 0.31 4.75e-9 IgG glycosylation; CRC cis rs8067545 1.000 rs7211535 chr17:19922364 A/G cg13482628 chr17:19912719 NA 0.54 8.62 0.43 2.95e-16 Schizophrenia; CRC cis rs1129187 0.755 rs13215983 chr6:42924193 C/T cg05552183 chr6:42928497 GNMT 0.52 7.93 0.4 3.49e-14 Alzheimer's disease in APOE e4+ carriers; CRC cis rs362272 0.545 rs2749782 chr4:3339761 A/G cg08741688 chr4:3415352 RGS12 -0.39 -5.6 -0.3 4.47e-8 Serum sulfate level; CRC cis rs9303401 0.615 rs35288118 chr17:56600748 A/C cg10487724 chr17:56770010 TEX14;RAD51C 0.8 9.24 0.45 3.14e-18 Cognitive test performance; CRC cis rs79839061 0.610 rs3775130 chr4:875144 G/A cg14530993 chr4:882597 GAK 0.8 7.31 0.37 1.99e-12 Intelligence (multi-trait analysis); CRC cis rs4974559 0.947 rs28711287 chr4:1346682 G/C cg02980000 chr4:1222292 CTBP1 0.72 8.18 0.41 6.4e-15 Systolic blood pressure; CRC cis rs1799949 1.000 rs11649954 chr17:41420035 A/G cg05368731 chr17:41323189 NBR1 0.67 10.14 0.49 3.45e-21 Menopause (age at onset); CRC cis rs3126085 0.515 rs1923503 chr1:152360820 G/A cg09127314 chr1:152161683 NA -0.44 -5.86 -0.31 1.13e-8 Atopic dermatitis; CRC cis rs9868809 0.505 rs13316551 chr3:48745167 A/C cg07636037 chr3:49044803 WDR6 -0.7 -6.77 -0.35 6.09e-11 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; CRC cis rs9457247 0.663 rs9295384 chr6:167448113 T/A cg07741184 chr6:167504864 NA 0.35 6.28 0.33 1.1e-9 Crohn's disease; CRC cis rs9905704 0.624 rs11652761 chr17:56986095 C/T cg12560992 chr17:57184187 TRIM37 0.62 9.36 0.46 1.33e-18 Testicular germ cell tumor; CRC cis rs17065868 1.000 rs73190824 chr13:45108587 G/C cg10246903 chr13:45222710 NA 0.53 5.67 0.3 3.14e-8 Antineutrophil cytoplasmic antibody-associated vasculitis; CRC cis rs921968 0.541 rs17462853 chr2:219345637 T/G cg02176678 chr2:219576539 TTLL4 -0.57 -9.18 -0.45 4.97e-18 Mean corpuscular hemoglobin concentration; CRC cis rs870825 0.616 rs67409049 chr4:185623989 G/A cg04058563 chr4:185651563 MLF1IP 0.72 9.38 0.46 1.12e-18 Blood protein levels; CRC cis rs35306767 0.903 rs11813210 chr10:919796 G/A cg20503657 chr10:835505 NA 0.97 12.22 0.56 1.45e-28 Eosinophil percentage of granulocytes; CRC cis rs4523957 0.928 rs9905529 chr17:2177732 T/C cg16513277 chr17:2031491 SMG6 -0.54 -9.12 -0.45 7.71e-18 Autism spectrum disorder or schizophrenia;Schizophrenia; CRC cis rs2070488 0.775 rs4679066 chr3:38568527 A/G cg01465620 chr3:38496096 LOC100128640;ACVR2B -0.76 -12.49 -0.57 1.49e-29 Electrocardiographic conduction measures; CRC cis rs709400 0.663 rs62007719 chr14:103943130 G/T cg12935359 chr14:103987150 CKB -0.51 -7.91 -0.4 3.85e-14 Body mass index; CRC cis rs7666738 0.830 rs1834647 chr4:98882915 G/A cg05340658 chr4:99064831 C4orf37 0.56 8.4 0.42 1.31e-15 Colonoscopy-negative controls vs population controls; CRC cis rs6662572 0.737 rs9429187 chr1:46558927 C/A cg08644498 chr1:46502608 NA 0.44 7.12 0.37 6.76e-12 Blood protein levels; CRC trans rs9388451 0.874 rs9398787 chr6:126090608 A/G cg05039488 chr6:79577232 IRAK1BP1 -0.54 -8.24 -0.41 4.07e-15 Brugada syndrome; CRC trans rs1814175 0.935 rs6485999 chr11:49658986 G/C cg15704280 chr7:45808275 SEPT13 -0.97 -18.29 -0.71 4.7e-52 Height; CRC cis rs875971 1.000 rs6958484 chr7:65599446 G/A cg18912574 chr7:65842487 NCRNA00174 -0.36 -6.2 -0.32 1.7e-9 Aortic root size; CRC cis rs6976053 0.935 rs4727470 chr7:100509201 A/G cg10426581 chr7:100472382 SRRT 0.38 5.79 0.3 1.62e-8 Plasminogen activator inhibitor type 1 levels (PAI-1); CRC cis rs4927850 0.752 rs7618864 chr3:195749561 G/A cg12923728 chr3:195709715 SDHAP1 -0.74 -12.03 -0.55 7.03e-28 Pancreatic cancer; CRC cis rs4713118 0.615 rs57252182 chr6:27720249 C/A cg06470822 chr6:28175283 NA 0.65 9.31 0.46 1.84e-18 Parkinson's disease; CRC cis rs7666738 0.861 rs5010991 chr4:98972179 A/G cg17366294 chr4:99064904 C4orf37 0.44 7.48 0.38 6.65e-13 Colonoscopy-negative controls vs population controls; CRC cis rs7772486 0.743 rs1292339 chr6:145967086 C/T cg23711669 chr6:146136114 FBXO30 -0.66 -10.96 -0.52 4.79e-24 Lobe attachment (rater-scored or self-reported); CRC cis rs3858526 0.883 rs7481923 chr11:5933342 T/C cg13902645 chr11:5959945 NA -0.6 -8.33 -0.42 2.2e-15 DNA methylation (variation); CRC trans rs10983614 1.000 rs7867776 chr9:120072627 A/G cg07283595 chr17:5372003 DHX33 0.44 6.07 0.32 3.5e-9 Survival in pancreatic cancer; CRC cis rs2576037 0.899 rs2246877 chr18:44577005 A/G cg20875182 chr18:44561130 TCEB3B;KATNAL2 -0.43 -6.46 -0.34 3.84e-10 Personality dimensions; CRC cis rs2108225 0.934 rs2190392 chr7:107452685 T/C cg18560240 chr7:107437656 SLC26A3 -0.65 -10.3 -0.49 9.46e-22 Ulcerative colitis; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg00006884 chr7:23637030 CCDC126 0.52 6.62 0.34 1.5e-10 Thyroid stimulating hormone; CRC cis rs7618915 0.547 rs33967311 chr3:52683864 G/T cg05573699 chr3:52720067 GNL3;PBRM1 -0.46 -6.56 -0.34 2.03e-10 Bipolar disorder; CRC cis rs753778 1.000 rs4961257 chr8:142232704 A/G cg18755752 chr8:142205143 DENND3 0.41 5.84 0.31 1.23e-8 Reticulocyte fraction of red cells;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; CRC cis rs9910055 0.529 rs228749 chr17:42174570 A/G cg13607699 chr17:42295918 UBTF -0.47 -6.16 -0.32 2.07e-9 Total body bone mineral density; CRC cis rs9462846 0.692 rs1819325 chr6:42859748 C/A cg10862848 chr6:42927986 GNMT -0.27 -5.7 -0.3 2.71e-8 Blood protein levels; CRC cis rs9487051 0.738 rs449850 chr6:109525045 A/G cg21918786 chr6:109611834 NA -0.33 -5.64 -0.3 3.67e-8 Reticulocyte fraction of red cells; CRC cis rs801193 1.000 rs2659906 chr7:66165310 T/C cg11764359 chr7:65958608 NA 0.55 8.52 0.43 5.79e-16 Aortic root size; CRC trans rs10435719 0.902 rs7014580 chr8:11803262 C/G cg06636001 chr8:8085503 FLJ10661 0.5 7.6 0.39 3.1e-13 C-reactive protein levels or triglyceride levels (pleiotropy); CRC cis rs4481887 0.927 rs11204637 chr1:248492581 G/A cg13385794 chr1:248469461 NA 0.38 6.56 0.34 2.08e-10 Common traits (Other); CRC cis rs2239547 0.522 rs6445550 chr3:52983434 G/A cg11645453 chr3:52864694 ITIH4 0.51 8.83 0.44 6.18e-17 Schizophrenia; CRC trans rs6833159 0.527 rs10939231 chr4:28829372 A/T cg24407065 chr1:169335802 BLZF1;NME7 0.45 6.44 0.33 4.25e-10 Underweight status; CRC cis rs9462027 0.628 rs7774697 chr6:34791027 C/T cg07306190 chr6:34760872 UHRF1BP1 0.34 6.02 0.32 4.62e-9 Systemic lupus erythematosus; CRC cis rs2204008 0.805 rs11180825 chr12:38242916 G/T cg13010199 chr12:38710504 ALG10B 0.45 5.75 0.3 2.07e-8 Bladder cancer; CRC cis rs17253792 0.822 rs79398217 chr14:56067350 C/T cg01858014 chr14:56050164 KTN1 -0.85 -6.69 -0.35 9.81e-11 Putamen volume; CRC cis rs2408955 0.522 rs4760679 chr12:48461635 G/T cg21466736 chr12:48725269 NA 0.45 7.07 0.36 9.6e-12 Glycated hemoglobin levels; CRC cis rs9291683 0.610 rs993173 chr4:10323935 T/C cg11266682 chr4:10021025 SLC2A9 -0.42 -8.31 -0.42 2.47e-15 Bone mineral density; CRC cis rs10504229 0.906 rs113823909 chr8:58170635 A/G cg22535103 chr8:58192502 C8orf71 -0.82 -12.22 -0.56 1.44e-28 Developmental language disorder (linguistic errors); CRC cis rs7937682 0.632 rs3944619 chr11:111774743 A/G cg09085632 chr11:111637200 PPP2R1B 0.94 14.87 0.63 1.28e-38 Primary sclerosing cholangitis; CRC cis rs7769051 0.522 rs62424539 chr6:133173272 C/T cg22852734 chr6:133119734 C6orf192 0.86 8.43 0.42 1.07e-15 Type 2 diabetes nephropathy; CRC cis rs10950821 0.806 rs28645540 chr7:20647637 T/A cg02470904 chr7:20686108 ABCB5 0.38 5.6 0.3 4.46e-8 Response to statin therapy; CRC cis rs3785574 0.962 rs2584630 chr17:61887561 T/A cg23090583 chr17:61904693 PSMC5;FTSJ3 0.65 9.25 0.45 3e-18 Height; CRC trans rs62103177 0.810 rs62103188 chr18:77627661 G/A cg05926928 chr17:57297772 GDPD1 1.06 9.97 0.48 1.21e-20 Opioid sensitivity; CRC cis rs875971 0.660 rs10272357 chr7:66063074 G/A cg11764359 chr7:65958608 NA -0.55 -8.65 -0.43 2.34e-16 Aortic root size; CRC cis rs11711311 1.000 rs9854504 chr3:113532381 C/T cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.53 -7.32 -0.37 1.89e-12 IgG glycosylation; CRC cis rs1008375 1.000 rs1974624 chr4:17650281 A/G cg04450456 chr4:17643702 FAM184B 0.36 5.86 0.31 1.11e-8 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs2404602 0.716 rs17461634 chr15:76764107 G/A cg22467129 chr15:76604101 ETFA -0.46 -7.73 -0.39 1.28e-13 Blood metabolite levels; CRC cis rs2303759 0.874 rs10411630 chr19:49891314 C/A cg22133161 chr19:49891603 CCDC155 0.52 7.07 0.36 9.14e-12 Multiple sclerosis; CRC cis rs10089 1.000 rs10060390 chr5:127452947 C/T cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.71 9.9 0.48 2.11e-20 Ileal carcinoids; CRC cis rs9322193 0.886 rs12525871 chr6:150097018 A/G cg05861140 chr6:150128134 PCMT1 -0.41 -6.59 -0.34 1.7e-10 Lung cancer; CRC cis rs270601 0.770 rs932019 chr5:131599370 T/C cg02033258 chr5:131593261 PDLIM4 0.47 8.87 0.44 4.83e-17 Acylcarnitine levels; CRC cis rs4466137 0.830 rs6886695 chr5:82994293 T/A cg15083037 chr5:83017644 HAPLN1 -0.5 -6.38 -0.33 5.91e-10 Prostate cancer; CRC cis rs3806843 0.576 rs246027 chr5:140333601 A/G cg19875535 chr5:140030758 IK 0.4 6.12 0.32 2.64e-9 Depressive symptoms (multi-trait analysis); CRC cis rs2251381 0.750 rs2251087 chr21:30527999 C/T cg24692254 chr21:30365293 RNF160 0.75 12.49 0.57 1.48e-29 Selective IgA deficiency; CRC cis rs2952156 0.920 rs903502 chr17:37829604 C/T cg11212589 chr17:38028394 ZPBP2 0.34 5.93 0.31 7.48e-9 Asthma; CRC cis rs2243480 0.711 rs2420172 chr7:65635341 T/C cg12463550 chr7:65579703 CRCP -0.71 -6.52 -0.34 2.61e-10 Diabetic kidney disease; CRC cis rs4964805 0.505 rs15918 chr12:104167024 T/C cg02344784 chr12:104178138 NT5DC3 0.42 6.28 0.33 1.09e-9 Attention deficit hyperactivity disorder; CRC cis rs4969178 0.965 rs8072632 chr17:76397830 T/C cg05887092 chr17:76393375 PGS1 0.55 10.0 0.48 1.01e-20 HDL cholesterol levels; CRC cis rs10256972 0.552 rs2960830 chr7:1200641 T/C cg03188948 chr7:1209495 NA 0.59 8.96 0.44 2.49e-17 Longevity;Endometriosis; CRC cis rs8114671 0.562 rs6058137 chr20:33475074 G/A cg07148914 chr20:33460835 GGT7 0.43 6.89 0.36 2.8e-11 Height; CRC cis rs9534288 0.797 rs2094246 chr13:46602163 C/T cg15192986 chr13:46630673 CPB2 -0.67 -9.81 -0.48 4.16e-20 Blood protein levels; CRC cis rs9322193 0.884 rs2095375 chr6:150128173 C/A cg00933542 chr6:150070202 PCMT1 0.28 5.63 0.3 3.86e-8 Lung cancer; CRC cis rs875971 0.862 rs6944374 chr7:65686929 C/G cg00343986 chr7:65444356 GUSB -0.49 -6.71 -0.35 8.36e-11 Aortic root size; CRC cis rs469568 0.562 rs11746802 chr5:178665185 C/T cg08999896 chr5:178685787 ADAMTS2 0.31 5.66 0.3 3.26e-8 Stroke (pediatric); CRC cis rs11792861 0.816 rs2304779 chr9:111670513 C/T cg05043794 chr9:111880884 C9orf5 0.31 5.69 0.3 2.87e-8 Menarche (age at onset); CRC cis rs1005277 0.602 rs1740743 chr10:38519222 C/T cg17219203 chr10:38645113 HSD17B7P2 -0.41 -5.92 -0.31 8.11e-9 Extrinsic epigenetic age acceleration; CRC trans rs7937682 0.889 rs1784787 chr11:111486125 T/A cg18187862 chr3:45730750 SACM1L 0.45 6.55 0.34 2.23e-10 Primary sclerosing cholangitis; CRC cis rs6674176 0.628 rs3791119 chr1:44431362 C/G cg13606994 chr1:44402422 ARTN -0.34 -5.76 -0.3 1.94e-8 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Cognitive ability; CRC cis rs116095464 0.558 rs61689490 chr5:224904 T/C cg22496380 chr5:211416 CCDC127 -0.84 -9.73 -0.47 7.72e-20 Breast cancer; CRC cis rs7772486 0.727 rs11155442 chr6:146140725 T/C cg13319975 chr6:146136371 FBXO30 -0.44 -6.58 -0.34 1.91e-10 Lobe attachment (rater-scored or self-reported); CRC cis rs6752107 1.000 rs13391356 chr2:234170369 T/C cg07618928 chr2:234183455 ATG16L1;SCARNA5 0.66 11.52 0.54 5.08e-26 Crohn's disease;Inflammatory bowel disease; CRC cis rs2242116 1.000 rs2168443 chr3:46947087 A/T cg27129171 chr3:47204927 SETD2 -0.55 -7.92 -0.4 3.78e-14 Birth weight; CRC cis rs6752107 0.837 rs3792108 chr2:234184952 T/C cg07618928 chr2:234183455 ATG16L1;SCARNA5 0.66 11.5 0.54 5.74e-26 Crohn's disease;Inflammatory bowel disease; CRC cis rs523522 0.962 rs10849759 chr12:120994488 T/A cg12219531 chr12:120966889 COQ5 0.68 9.13 0.45 7.23e-18 High light scatter reticulocyte count; CRC cis rs17767392 0.756 rs61989256 chr14:71729964 C/T cg13720639 chr14:72061746 SIPA1L1 -0.52 -6.36 -0.33 6.63e-10 Mitral valve prolapse; CRC cis rs6076065 0.723 rs2051093 chr20:23371349 G/A cg11657817 chr20:23433608 CST11 0.45 6.69 0.35 9.76e-11 Facial morphology (factor 15, philtrum width); CRC cis rs2976388 0.565 rs2572905 chr8:143797104 C/T cg12516270 chr8:143859308 LYNX1 0.41 7.42 0.38 1e-12 Urinary tract infection frequency; CRC trans rs34308817 0.509 rs7426901 chr3:181361312 C/G cg10852698 chr6:46375852 NA -0.45 -5.97 -0.31 6.03e-9 Ankle injury; CRC cis rs425277 0.628 rs10797427 chr1:2060732 C/T cg03732007 chr1:2071316 PRKCZ -0.36 -5.73 -0.3 2.28e-8 Height; CRC cis rs7412746 0.611 rs1889740 chr1:150799755 C/T cg17724175 chr1:150552817 MCL1 0.43 6.6 0.34 1.63e-10 Melanoma; CRC cis rs1401999 0.966 rs1533682 chr3:183634879 A/G cg20387954 chr3:183756860 HTR3D 0.45 7.6 0.39 3.11e-13 Anterior chamber depth; CRC cis rs6952808 0.609 rs6950151 chr7:1953521 T/C cg22963979 chr7:1858916 MAD1L1 -0.43 -6.83 -0.35 4.07e-11 Bipolar disorder and schizophrenia; CRC cis rs8060686 0.516 rs11075670 chr16:68288393 C/G cg26727032 chr16:67993705 SLC12A4 -0.61 -8.73 -0.43 1.33e-16 HDL cholesterol;Metabolic syndrome; CRC cis rs7635838 0.573 rs73019547 chr3:11493323 A/C cg00170343 chr3:11313890 ATG7 0.46 7.12 0.37 6.84e-12 HDL cholesterol; CRC cis rs6502050 0.799 rs34795957 chr17:80118013 G/A cg19223190 chr17:80058835 NA 0.38 6.17 0.32 2e-9 Life satisfaction; CRC cis rs57590327 0.508 rs4605572 chr3:81965751 A/G cg07356753 chr3:81810745 GBE1 -0.47 -6.26 -0.33 1.2e-9 Extraversion; CRC cis rs8170 1.000 rs8170 chr19:17389704 G/A cg04749549 chr19:17459798 NA -0.45 -6.11 -0.32 2.76e-9 Breast cancer (estrogen-receptor negative);Breast Cancer in BRCA1 mutation carriers;Ovarian cancer;Breast cancer;Epithelial ovarian cancer; CRC cis rs1799949 1.000 rs11653231 chr17:41331460 G/A cg05368731 chr17:41323189 NBR1 0.68 10.42 0.5 3.68e-22 Menopause (age at onset); CRC cis rs9291683 0.588 rs4697705 chr4:10108127 G/A cg00071950 chr4:10020882 SLC2A9 -0.5 -8.51 -0.42 6.33e-16 Bone mineral density; CRC cis rs58235267 0.543 rs2539990 chr2:63170185 C/T cg17519650 chr2:63277830 OTX1 0.51 7.67 0.39 1.95e-13 Prostate-specific antigen levels (conditioned on lead SNPs); CRC trans rs8002861 0.810 rs2275252 chr13:44454374 A/C cg17145862 chr1:211918768 LPGAT1 0.75 14.88 0.63 1.14e-38 Leprosy; CRC cis rs801193 1.000 rs10234018 chr7:66146284 A/T cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.41 -6.05 -0.32 4e-9 Aortic root size; CRC trans rs12195424 0.730 rs9475698 chr6:56298924 A/G cg03771185 chr4:775700 NA 0.52 6.2 0.32 1.68e-9 Cerebrospinal fluid clusterin levels; CRC cis rs1707322 0.721 rs10789468 chr1:46124558 A/G cg06784218 chr1:46089804 CCDC17 0.62 11.61 0.54 2.35e-26 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs7246657 0.943 rs10415358 chr19:37808863 C/A cg23950597 chr19:37808831 NA -0.52 -6.09 -0.32 3.16e-9 Coronary artery calcification; CRC cis rs9322193 0.923 rs9688452 chr6:149979900 G/A cg07701084 chr6:150067640 NUP43 0.56 8.16 0.41 7.17e-15 Lung cancer; CRC cis rs6912958 0.712 rs9444526 chr6:88326402 A/G cg08069147 chr6:88032118 GJB7;C6orf162 -0.57 -8.61 -0.43 3.09e-16 Monocyte percentage of white cells; CRC cis rs9354352 0.818 rs9453548 chr6:66691885 T/C cg07460842 chr6:66804631 NA -0.62 -9.24 -0.45 3.08e-18 Initial pursuit acceleration in psychotic disorders; CRC trans rs6951245 1.000 rs77305932 chr7:1100861 T/A cg13565492 chr6:43139072 SRF -0.72 -7.44 -0.38 8.63e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs9837602 0.938 rs9873709 chr3:99711687 G/A cg07805332 chr3:99536008 MIR548G;C3orf26 -0.49 -6.67 -0.35 1.1e-10 Breast cancer; CRC cis rs4808199 0.948 rs757001 chr19:19448808 G/A cg03709012 chr19:19516395 GATAD2A 0.96 11.1 0.52 1.55e-24 Nonalcoholic fatty liver disease; CRC cis rs28386778 0.863 rs2727355 chr17:61931790 C/T cg22520471 chr17:61851767 DDX42;CCDC47 0.73 11.34 0.53 2.15e-25 Prudent dietary pattern; CRC cis rs2252521 0.526 rs317704 chr7:29087343 T/G cg11728747 chr7:29037910 CPVL -0.47 -6.68 -0.35 1.02e-10 Cognitive performance; CRC cis rs7223966 1.000 rs11079511 chr17:61858537 C/G cg23090583 chr17:61904693 PSMC5;FTSJ3 0.55 6.62 0.34 1.47e-10 Hip circumference adjusted for BMI;Body mass index; CRC cis rs1577917 0.727 rs9344539 chr6:86353621 A/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.51 -7.08 -0.36 8.81e-12 Response to antipsychotic treatment; CRC cis rs6604026 0.656 rs2811596 chr1:93341223 A/G cg17283838 chr1:93427260 FAM69A -0.43 -5.6 -0.3 4.52e-8 Multiple sclerosis; CRC cis rs11122272 0.735 rs2808592 chr1:231523757 G/A cg06096015 chr1:231504339 EGLN1 0.4 5.98 0.31 5.78e-9 Hemoglobin concentration; CRC cis rs1129187 0.755 rs3818554 chr6:42934620 C/T cg26304593 chr6:42947056 PEX6 -0.45 -6.65 -0.34 1.24e-10 Alzheimer's disease in APOE e4+ carriers; CRC cis rs644799 0.965 rs3016295 chr11:95554311 A/G cg25622487 chr11:95524042 FAM76B;CEP57 0.75 11.78 0.54 5.79e-27 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs7927771 1.000 rs4752857 chr11:47655752 C/T cg05585544 chr11:47624801 NA -0.61 -11.31 -0.53 2.74e-25 Subjective well-being; CRC cis rs1577917 0.958 rs1545376 chr6:86504582 C/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A 0.52 6.77 0.35 6.02e-11 Response to antipsychotic treatment; CRC cis rs13108904 0.875 rs1732099 chr4:1282696 T/C cg15763984 chr4:1342303 KIAA1530 -0.35 -6.05 -0.32 3.95e-9 Obesity-related traits; CRC cis rs12410462 0.681 rs115956039 chr1:227661978 G/A cg04117972 chr1:227635322 NA 0.8 8.03 0.4 1.79e-14 Major depressive disorder; CRC cis rs4713118 0.869 rs10214440 chr6:27702440 A/C cg08798685 chr6:27730294 NA -0.43 -6.2 -0.32 1.66e-9 Parkinson's disease; CRC cis rs12476592 0.516 rs1348804 chr2:63895672 C/T cg10828910 chr2:63850056 LOC388955 0.5 6.26 0.33 1.23e-9 Childhood ear infection; CRC cis rs9611565 0.659 rs28530678 chr22:41934961 G/C cg06634786 chr22:41940651 POLR3H -0.69 -7.78 -0.39 9.14e-14 Vitiligo; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg06596689 chr7:139875956 LOC100134229;JHDM1D -0.4 -6.47 -0.34 3.49e-10 Myopia (pathological); CRC cis rs2243480 1.000 rs67536397 chr7:65947917 G/A cg18252515 chr7:66147081 NA -1.27 -14.68 -0.63 7.35e-38 Diabetic kidney disease; CRC cis rs939584 0.877 rs6548240 chr2:636929 C/A cg03610516 chr2:642275 NA 0.43 5.77 0.3 1.8e-8 Body mass index; CRC trans rs3780486 0.846 rs6476399 chr9:33123013 A/G cg20290983 chr6:43655470 MRPS18A 1.16 26.88 0.83 5.33e-85 IgG glycosylation; CRC cis rs10751667 0.961 rs7479171 chr11:926809 G/A cg23136738 chr11:925521 AP2A2 -0.5 -7.9 -0.4 4.34e-14 Alzheimer's disease (late onset); CRC cis rs11971779 0.680 rs4732373 chr7:139086535 T/G cg23387468 chr7:139079360 LUC7L2 0.41 7.04 0.36 1.14e-11 Diisocyanate-induced asthma; CRC trans rs2303319 0.504 rs1006428 chr2:162592559 A/C cg27342122 chr8:133787442 PHF20L1 -0.72 -6.12 -0.32 2.68e-9 Cognitive function; CRC cis rs10979 1.000 rs9386037 chr6:143891950 T/C cg25407410 chr6:143891975 LOC285740 -0.83 -13.43 -0.6 4.27e-33 Hypospadias; CRC trans rs10982213 0.830 rs2274163 chr9:117188714 C/T cg18800192 chr19:42388471 ARHGEF1 0.39 6.01 0.31 5.04e-9 Interleukin-6 levels; CRC cis rs3796619 1.000 rs1453605 chr4:1075771 C/T cg27284194 chr4:1044797 NA 0.42 6.42 0.33 4.85e-10 Recombination rate (males); CRC cis rs9399135 0.967 rs7766189 chr6:135353851 A/C cg24558204 chr6:135376177 HBS1L 0.51 8.07 0.41 1.34e-14 Red blood cell count; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg15846643 chr11:94964345 SESN3 0.41 7.64 0.39 2.42e-13 Liver disease severity in Alagille syndrome; CRC cis rs6951245 0.832 rs79808627 chr7:1092519 C/G cg26224354 chr7:1096374 C7orf50;GPR146 -0.8 -11.41 -0.53 1.22e-25 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs2075371 1.000 rs2598296 chr7:133992985 C/T cg20476274 chr7:133979776 SLC35B4 0.82 14.89 0.63 1.05e-38 Mean platelet volume; CRC cis rs7309 0.935 rs6432674 chr2:162025322 G/T cg13854012 chr2:162103682 NA -0.47 -7.63 -0.39 2.56e-13 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Educational attainment; CRC cis rs2239547 0.603 rs4687698 chr3:53097108 C/T cg11645453 chr3:52864694 ITIH4 0.51 8.57 0.43 4.13e-16 Schizophrenia; CRC cis rs7614311 0.681 rs6809100 chr3:63901180 A/G cg22134162 chr3:63841271 THOC7 -0.59 -5.95 -0.31 6.77e-9 Lung function (FVC);Lung function (FEV1); CRC cis rs801193 0.839 rs12534943 chr7:66070520 A/G cg18876405 chr7:65276391 NA -0.6 -10.65 -0.51 5.8e-23 Aortic root size; CRC cis rs7811142 1.000 rs7794485 chr7:100068936 T/C cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.58 7.14 0.37 6.05e-12 Platelet count; CRC cis rs10779751 1.000 rs4845986 chr1:11288633 G/C cg08854313 chr1:11322531 MTOR 0.69 9.97 0.48 1.28e-20 Body mass index; CRC cis rs929354 0.772 rs933344 chr7:157011265 A/T cg05182265 chr7:156933206 UBE3C -0.76 -14.49 -0.62 3.8e-37 Body mass index; CRC cis rs6735179 0.607 rs10202812 chr2:1746468 A/T cg19300414 chr2:1746591 PXDN 0.43 7.01 0.36 1.34e-11 Response to antipsychotic treatment; CRC cis rs1552244 1.000 rs113153120 chr3:10156398 G/A cg02579736 chr3:10068473 FANCD2;CIDECP 1.03 13.46 0.6 3.42e-33 Alzheimer's disease; CRC cis rs1448094 0.511 rs4462416 chr12:86150966 T/C cg19622623 chr12:86230825 RASSF9 0.4 6.39 0.33 5.55e-10 Major depressive disorder; CRC trans rs4942242 0.583 rs1027413 chr13:44224212 C/T cg19169023 chr15:41853346 TYRO3 0.44 6.45 0.34 3.91e-10 Response to tocilizumab in rheumatoid arthritis; CRC trans rs10504229 1.000 rs17216957 chr8:58179893 C/T cg04077850 chr5:125800366 GRAMD3 0.37 6.27 0.33 1.15e-9 Developmental language disorder (linguistic errors); CRC cis rs7811142 0.887 rs35111986 chr7:100000274 C/A cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.99 13.02 0.58 1.48e-31 Platelet count; CRC cis rs2439831 0.681 rs28578454 chr15:43603032 G/A cg20114781 chr15:43622253 ADAL;LCMT2 0.56 6.0 0.31 5.11e-9 Lung cancer in ever smokers; CRC cis rs9311474 0.508 rs12637627 chr3:52619962 G/T cg08222913 chr3:52553049 STAB1 -0.34 -6.28 -0.33 1.07e-9 Electroencephalogram traits; CRC cis rs9443645 0.901 rs6940637 chr6:79705845 C/T cg05283184 chr6:79620031 NA -0.61 -9.68 -0.47 1.16e-19 Intelligence (multi-trait analysis); CRC cis rs995000 0.899 rs1167998 chr1:62931632 C/A cg19896129 chr1:63156450 NA -0.39 -5.91 -0.31 8.5e-9 Triglyceride levels; CRC trans rs7615952 0.512 rs2922175 chr3:125361360 T/C cg08546805 chr12:8549446 NA -0.43 -6.55 -0.34 2.26e-10 Blood pressure (smoking interaction); CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg03546505 chr14:105266900 ZBTB42 0.44 5.98 0.31 5.71e-9 Anxiety disorder; CRC cis rs7113874 0.569 rs2289921 chr11:8496611 G/C cg02811074 chr11:8615871 STK33 0.36 6.13 0.32 2.48e-9 Body mass index in physically active individuals;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs7927771 0.832 rs10769258 chr11:47391039 C/T cg20307385 chr11:47447363 PSMC3 0.62 9.29 0.46 2.19e-18 Subjective well-being; CRC cis rs7727544 0.636 rs2631365 chr5:131705949 T/C cg24060327 chr5:131705240 SLC22A5 0.39 6.25 0.33 1.25e-9 Blood metabolite levels; CRC cis rs172166 0.694 rs1225716 chr6:28113746 A/C cg15845792 chr6:28175446 NA 0.82 12.17 0.56 2.24e-28 Cardiac Troponin-T levels; CRC cis rs6502050 0.871 rs6502056 chr17:80070912 C/G cg19223190 chr17:80058835 NA -0.43 -6.81 -0.35 4.54e-11 Life satisfaction; CRC cis rs875971 0.862 rs35034167 chr7:65580166 C/G cg00343986 chr7:65444356 GUSB -0.41 -5.85 -0.31 1.2e-8 Aortic root size; CRC cis rs6543140 0.964 rs6543144 chr2:103092575 A/G cg04239558 chr2:103089729 SLC9A4 0.35 6.11 0.32 2.84e-9 Blood protein levels; CRC cis rs523522 0.962 rs4767905 chr12:120930835 C/T cg12219531 chr12:120966889 COQ5 0.69 9.31 0.46 1.85e-18 High light scatter reticulocyte count; CRC cis rs9325144 0.560 rs6582561 chr12:38666821 G/A cg13010199 chr12:38710504 ALG10B -0.42 -6.17 -0.32 2.01e-9 Morning vs. evening chronotype; CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg15351736 chr11:111808104 DIXDC1 -0.48 -5.97 -0.31 6.13e-9 Diisocyanate-induced asthma; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg02941376 chr17:1613939 TLCD2 0.46 6.63 0.34 1.36e-10 Response to antipsychotic treatment; CRC cis rs5758511 0.680 rs5758652 chr22:42612408 T/C cg00645731 chr22:42541494 CYP2D7P1 0.66 10.17 0.49 2.71e-21 Birth weight; CRC trans rs2727020 0.553 rs3862350 chr11:49595912 A/C cg11707556 chr5:10655725 ANKRD33B -0.41 -7.65 -0.39 2.25e-13 Coronary artery disease; CRC cis rs2832191 0.791 rs2832186 chr21:30484151 A/C cg24692254 chr21:30365293 RNF160 -0.7 -12.42 -0.56 2.63e-29 Dental caries; CRC cis rs7937682 0.562 rs527847 chr11:111369132 A/C cg19812747 chr11:111475976 SIK2 0.5 8.05 0.41 1.5e-14 Primary sclerosing cholangitis; CRC cis rs1552244 1.000 rs17032295 chr3:10086680 C/T cg02579736 chr3:10068473 FANCD2;CIDECP 1.0 13.78 0.6 2e-34 Alzheimer's disease; CRC cis rs344364 0.511 rs62040569 chr16:1948137 C/T cg03013636 chr16:1946785 NA 0.58 7.08 0.36 8.69e-12 Glomerular filtration rate in chronic kidney disease; CRC cis rs853679 0.550 rs9295762 chr6:28155418 C/T cg12172441 chr6:28176163 NA -0.65 -8.54 -0.43 5.04e-16 Depression; CRC cis rs7772486 0.720 rs6570713 chr6:146075085 G/A cg05347473 chr6:146136440 FBXO30 -0.38 -5.71 -0.3 2.59e-8 Lobe attachment (rater-scored or self-reported); CRC cis rs3741151 1.000 rs7122825 chr11:73061324 C/T cg17517138 chr11:73019481 ARHGEF17 1.08 9.22 0.45 3.7e-18 GIP levels in response to oral glucose tolerance test (120 minutes); CRC cis rs9858542 0.953 rs9841110 chr3:49492481 C/G cg07274523 chr3:49395745 GPX1 0.47 6.4 0.33 5.33e-10 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs2032447 0.901 rs1540276 chr6:26028819 T/G cg04800585 chr6:26043546 HIST1H2BB 0.57 8.39 0.42 1.48e-15 Intelligence (multi-trait analysis); CRC cis rs875971 0.862 rs12698526 chr7:65969105 T/C cg11764359 chr7:65958608 NA 0.58 8.69 0.43 1.8e-16 Aortic root size; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg26339992 chr1:28241106 RPA2 0.41 7.04 0.36 1.13e-11 Liver disease severity in Alagille syndrome; CRC cis rs561341 1.000 rs7216102 chr17:30259450 A/G cg12193833 chr17:30244370 NA -0.57 -7.99 -0.4 2.3e-14 Hip circumference adjusted for BMI; CRC trans rs10411161 0.702 rs16983200 chr19:52386723 G/A cg22319618 chr22:45562946 NUP50 -0.67 -7.41 -0.38 1.06e-12 Breast cancer; CRC cis rs4819052 0.851 rs4819049 chr21:46673086 C/G cg11663144 chr21:46675770 NA -0.83 -14.28 -0.62 2.38e-36 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC trans rs17685 0.671 rs60303271 chr7:75760008 A/G cg19862616 chr7:65841803 NCRNA00174 0.99 18.11 0.71 2.51e-51 Coffee consumption;Coffee consumption (cups per day); CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg20607769 chr12:53491735 IGFBP6 0.44 6.62 0.34 1.48e-10 Anxiety disorder; CRC cis rs4654899 0.549 rs4654873 chr1:21152384 G/A cg02927042 chr1:21476669 EIF4G3 -0.42 -6.3 -0.33 9.59e-10 Superior frontal gyrus grey matter volume; CRC cis rs703842 1.000 rs10877019 chr12:58172929 A/G cg00677455 chr12:58241039 CTDSP2 -0.62 -8.24 -0.41 4.18e-15 Multiple sclerosis; CRC cis rs6089584 0.816 rs744778 chr20:60631365 A/G cg06108461 chr20:60628389 TAF4 -0.9 -15.55 -0.65 2.87e-41 Body mass index; CRC cis rs7107174 0.892 rs11237463 chr11:78060464 A/G cg02023728 chr11:77925099 USP35 0.5 7.61 0.39 2.92e-13 Testicular germ cell tumor; CRC cis rs6502050 0.835 rs7406529 chr17:80080877 C/T cg13198984 chr17:80129470 CCDC57 -0.46 -7.97 -0.4 2.65e-14 Life satisfaction; CRC cis rs425277 0.606 rs2257182 chr1:2082566 C/T cg21194808 chr1:2205498 SKI -0.36 -5.74 -0.3 2.12e-8 Height; CRC cis rs7666738 0.830 rs10470894 chr4:99039107 G/A cg17366294 chr4:99064904 C4orf37 0.43 7.16 0.37 5.31e-12 Colonoscopy-negative controls vs population controls; CRC cis rs7666738 0.830 rs4699584 chr4:98952019 A/G cg17366294 chr4:99064904 C4orf37 0.43 7.34 0.38 1.69e-12 Colonoscopy-negative controls vs population controls; CRC cis rs1448094 0.802 rs11117146 chr12:86382870 C/T cg02569458 chr12:86230093 RASSF9 -0.4 -6.64 -0.34 1.33e-10 Major depressive disorder; CRC cis rs3733585 0.699 rs6839490 chr4:9965000 C/G cg11266682 chr4:10021025 SLC2A9 0.43 8.54 0.43 5.08e-16 Cleft plate (environmental tobacco smoke interaction); CRC trans rs916888 0.610 rs142167 chr17:44795234 C/T cg07870213 chr5:140052090 DND1 -0.61 -7.72 -0.39 1.38e-13 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs2976388 0.590 rs3736011 chr8:143817789 G/A cg12516270 chr8:143859308 LYNX1 -0.4 -6.6 -0.34 1.65e-10 Urinary tract infection frequency; CRC trans rs12887734 0.546 rs12885509 chr14:104273325 T/C cg06206626 chr22:26825900 ASPHD2 0.41 6.18 0.32 1.94e-9 Schizophrenia;Autism spectrum disorder or schizophrenia; CRC cis rs9463078 0.677 rs7739928 chr6:45068053 G/C cg25276700 chr6:44698697 NA -0.25 -5.96 -0.31 6.63e-9 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; CRC cis rs875971 0.540 rs736270 chr7:65428822 T/C cg05627663 chr7:65219948 SNORA22;CCT6P1 0.47 6.81 0.35 4.56e-11 Aortic root size; CRC cis rs11969893 0.850 rs3734351 chr6:101307131 C/T cg12253828 chr6:101329408 ASCC3 1.14 8.76 0.43 1.03e-16 Economic and political preferences (immigration/crime); CRC cis rs7586879 0.616 rs6545813 chr2:25131287 C/T cg04586622 chr2:25135609 ADCY3 -0.54 -10.18 -0.49 2.43e-21 Body mass index; CRC cis rs523522 0.962 rs2393590 chr12:120913900 G/A cg12219531 chr12:120966889 COQ5 0.7 9.24 0.45 3.24e-18 High light scatter reticulocyte count; CRC cis rs7193541 0.662 rs8058133 chr16:74657485 A/T cg01733217 chr16:74700730 RFWD3 1.02 20.87 0.75 3.48e-62 Multiple myeloma; CRC trans rs11088226 0.538 rs4816436 chr21:33880251 A/G cg09050820 chr6:167586206 TCP10L2 0.54 7.42 0.38 9.76e-13 Gastritis; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg20972416 chr2:220025218 NHEJ1 0.41 6.01 0.31 5.04e-9 Response to antipsychotic treatment; CRC cis rs9491140 0.539 rs10872283 chr6:124685919 G/A cg05308643 chr6:124982296 NKAIN2 0.49 6.76 0.35 6.19e-11 Neuroticism; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg10719100 chr8:146078187 COMMD5 -0.39 -6.12 -0.32 2.64e-9 Myopia (pathological); CRC cis rs1552244 0.882 rs6443276 chr3:10008905 C/A cg10729496 chr3:10149963 C3orf24 0.5 6.65 0.34 1.22e-10 Alzheimer's disease; CRC cis rs9527 0.545 rs35756290 chr10:104585572 G/A cg04362960 chr10:104952993 NT5C2 0.64 7.9 0.4 4.18e-14 Arsenic metabolism; CRC cis rs728616 0.867 rs17879726 chr10:81698723 G/A cg05935833 chr10:81318306 SFTPA2 -0.72 -8.19 -0.41 5.66e-15 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs6456156 0.586 rs7742305 chr6:167485723 C/T cg07741184 chr6:167504864 NA 0.38 6.65 0.34 1.21e-10 Primary biliary cholangitis; CRC trans rs3960554 0.808 rs61303167 chr7:75671175 G/T cg19862616 chr7:65841803 NCRNA00174 0.71 8.44 0.42 1.03e-15 Eotaxin levels; CRC cis rs243505 1.000 rs243511 chr7:148430148 A/C cg09806900 chr7:148480153 CUL1 -0.44 -6.26 -0.33 1.17e-9 Inflammatory bowel disease;Crohn's disease; CRC cis rs1448094 0.511 rs4559760 chr12:86149414 G/A cg02569458 chr12:86230093 RASSF9 -0.48 -8.08 -0.41 1.27e-14 Major depressive disorder; CRC cis rs317689 0.581 rs315132 chr12:69761996 G/C cg14784868 chr12:69753453 YEATS4 0.66 9.02 0.45 1.57e-17 Response to diuretic therapy; CRC trans rs11581859 0.901 rs72730328 chr1:99395309 C/A cg12183875 chr3:169587454 LRRC31 0.28 6.34 0.33 7.78e-10 Response to cognitive-behavioural therapy in anxiety disorder; CRC cis rs2859741 0.967 rs592520 chr1:37513503 G/C cg09363841 chr1:37513479 NA -0.65 -12.44 -0.57 2.16e-29 Forced expiratory volume in 1 second (environmental tobacco smoke interaction); CRC cis rs736408 0.527 rs2577831 chr3:52628056 C/A cg18404041 chr3:52824283 ITIH1 -0.31 -6.31 -0.33 8.93e-10 Bipolar disorder; CRC cis rs7727544 0.735 rs272867 chr5:131681057 G/A cg12564285 chr5:131593104 PDLIM4 0.32 5.82 0.31 1.36e-8 Blood metabolite levels; CRC cis rs6681460 0.966 rs10789214 chr1:67146817 C/T cg02459107 chr1:67143332 SGIP1 0.45 7.97 0.4 2.56e-14 Presence of antiphospholipid antibodies; CRC trans rs61931739 0.534 rs10844767 chr12:34152368 C/G cg26384229 chr12:38710491 ALG10B 0.55 7.06 0.36 1e-11 Morning vs. evening chronotype; CRC cis rs11622475 1.000 rs8021692 chr14:104428576 C/G cg20488157 chr14:104394430 TDRD9 0.68 9.82 0.48 3.87e-20 Bipolar disorder; CRC cis rs1707322 1.000 rs1768817 chr1:46514534 C/G cg03146154 chr1:46216737 IPP -0.51 -7.09 -0.36 8.16e-12 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs62244186 0.541 rs9859879 chr3:44840166 G/A cg10263370 chr3:44754102 ZNF502 -0.35 -5.86 -0.31 1.12e-8 Depressive symptoms; CRC cis rs9322193 0.923 rs7769101 chr6:150169904 C/A cg13206674 chr6:150067644 NUP43 0.58 8.46 0.42 9.1e-16 Lung cancer; CRC trans rs9650657 0.615 rs6601534 chr8:10691993 A/G cg06636001 chr8:8085503 FLJ10661 -0.41 -6.17 -0.32 2.04e-9 Neuroticism; CRC cis rs1008375 0.932 rs4698626 chr4:17605821 G/C cg16339924 chr4:17578868 LAP3 0.47 6.32 0.33 8.36e-10 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs5769707 0.933 rs2157444 chr22:49994292 A/G cg05373962 chr22:49881684 NA -0.33 -6.33 -0.33 8.16e-10 Monocyte count;Monocyte percentage of white cells; CRC cis rs1008375 0.966 rs1860599 chr4:17638900 T/C cg04450456 chr4:17643702 FAM184B 0.41 6.7 0.35 9.11e-11 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs1862618 0.526 rs2591963 chr5:56237135 T/A cg24531977 chr5:56204891 C5orf35 1.0 14.46 0.62 4.91e-37 Initial pursuit acceleration; CRC cis rs2932538 0.922 rs2273369 chr1:113072477 A/G cg22162597 chr1:113214053 CAPZA1 0.69 9.57 0.47 2.6e-19 Systolic blood pressure;Diastolic blood pressure;Hypertension;Blood pressure; CRC cis rs853679 0.546 rs200990 chr6:27815823 T/G cg06470822 chr6:28175283 NA 0.67 5.85 0.31 1.22e-8 Depression; CRC cis rs9322193 0.923 rs9766037 chr6:149938057 A/C cg13206674 chr6:150067644 NUP43 0.6 9.02 0.45 1.6e-17 Lung cancer; CRC cis rs4789693 0.872 rs28612648 chr17:80403386 G/A cg04308225 chr17:80449738 NA 0.53 6.87 0.35 3.3e-11 Glucocorticoid-induced osteonecrosis; CRC cis rs2046867 0.862 rs11922794 chr3:72813582 G/C cg25664220 chr3:72788482 NA -0.4 -6.01 -0.31 4.94e-9 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; CRC trans rs2243480 1.000 rs781150 chr7:65480973 C/T cg10756647 chr7:56101905 PSPH 0.78 8.1 0.41 1.08e-14 Diabetic kidney disease; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg15993354 chr19:12912590 PRDX2 0.37 6.02 0.31 4.67e-9 Liver disease severity in Alagille syndrome; CRC trans rs1814175 0.645 rs1851857 chr11:49855589 A/C cg03929089 chr4:120376271 NA -0.91 -15.71 -0.65 6.72e-42 Height; CRC cis rs4363385 0.510 rs11812015 chr1:153045584 G/T cg25856811 chr1:152973957 SPRR3 -0.21 -5.69 -0.3 2.74e-8 Inflammatory skin disease; CRC cis rs853679 0.517 rs9380055 chr6:28081629 A/G cg06470822 chr6:28175283 NA 1.0 13.06 0.58 1.06e-31 Depression; CRC cis rs10479542 0.784 rs7703730 chr5:178986632 C/A cg19626725 chr5:178986131 RUFY1 -0.3 -5.81 -0.31 1.46e-8 Lung cancer; CRC cis rs875971 0.830 rs427575 chr7:65519219 A/G cg18912574 chr7:65842487 NCRNA00174 0.37 6.3 0.33 9.63e-10 Aortic root size; CRC cis rs4780401 0.609 rs35902600 chr16:11800848 C/T cg01061890 chr16:11836724 TXNDC11 -0.6 -8.84 -0.44 6.03e-17 Rheumatoid arthritis; CRC cis rs910187 0.538 rs2868849 chr20:45802273 G/A cg27589058 chr20:45804311 EYA2 -0.44 -8.79 -0.44 8.22e-17 Migraine; CRC cis rs453301 0.686 rs11785819 chr8:8870378 T/G cg06636001 chr8:8085503 FLJ10661 -0.5 -7.44 -0.38 8.78e-13 Joint mobility (Beighton score); CRC cis rs447 0.806 rs6974494 chr7:83743961 A/G cg22846510 chr7:83753280 SEMA3A 0.41 5.72 0.3 2.43e-8 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs7827545 1.000 rs6578238 chr8:135569490 A/C cg17885191 chr8:135476712 NA 0.51 7.2 0.37 4e-12 Hypertension (SNP x SNP interaction); CRC cis rs853679 0.517 rs9468292 chr6:28095355 G/A cg25164649 chr6:28176230 NA 0.76 9.53 0.46 3.71e-19 Depression; CRC cis rs6952808 0.531 rs73039217 chr7:2178731 G/A cg21782813 chr7:2030301 MAD1L1 0.5 8.44 0.42 1.03e-15 Bipolar disorder and schizophrenia; CRC cis rs7615952 0.599 rs67575510 chr3:125742355 C/G cg15145296 chr3:125709740 NA -0.57 -6.5 -0.34 2.98e-10 Blood pressure (smoking interaction); CRC cis rs9322193 0.923 rs66516768 chr6:149993135 C/T cg07701084 chr6:150067640 NUP43 0.61 9.06 0.45 1.15e-17 Lung cancer; CRC cis rs9443645 0.527 rs12196485 chr6:79556871 A/G cg05283184 chr6:79620031 NA -0.43 -6.34 -0.33 7.38e-10 Intelligence (multi-trait analysis); CRC cis rs9435341 0.965 rs1335055 chr1:107624563 A/G cg14828511 chr1:107599125 PRMT6 0.45 6.54 0.34 2.32e-10 Facial morphology (factor 21, depth of nasal alae); CRC cis rs1799949 1.000 rs8176145 chr17:41249094 A/G cg19454999 chr17:41278357 BRCA1;NBR2 0.56 8.69 0.43 1.78e-16 Menopause (age at onset); CRC cis rs9649213 0.614 rs2240348 chr7:97984077 C/T cg09267113 chr7:98030324 BAIAP2L1 -0.89 -12.03 -0.55 7.14e-28 Prostate cancer (SNP x SNP interaction); CRC cis rs9527 0.569 rs10883801 chr10:104677887 A/C cg04362960 chr10:104952993 NT5C2 0.59 8.45 0.42 9.26e-16 Arsenic metabolism; CRC cis rs4076764 0.914 rs4638099 chr1:163365521 A/G cg06092702 chr1:163392909 NA 0.56 8.83 0.44 6.58e-17 Motion sickness; CRC cis rs7107174 0.681 rs10793301 chr11:78020913 G/T cg02023728 chr11:77925099 USP35 0.54 7.6 0.39 3.18e-13 Testicular germ cell tumor; CRC cis rs6952808 1.000 rs10260585 chr7:1889521 G/A cg20295408 chr7:1910781 MAD1L1 -0.44 -6.06 -0.32 3.81e-9 Bipolar disorder and schizophrenia; CRC cis rs6860806 0.507 rs272872 chr5:131675864 C/T cg20512303 chr5:131592959 PDLIM4 -0.38 -6.69 -0.35 9.62e-11 Breast cancer; CRC cis rs2180341 0.960 rs9398840 chr6:127669744 G/A cg24812749 chr6:127587940 RNF146 0.95 13.32 0.59 1.16e-32 Breast cancer; CRC cis rs75920871 0.588 rs1871756 chr11:116953645 G/A cg20608306 chr11:116969690 SIK3 -0.31 -5.69 -0.3 2.78e-8 Subjective well-being; CRC cis rs6032067 0.929 rs13043503 chr20:43805835 T/C cg10761708 chr20:43804764 PI3 0.51 5.89 0.31 9.53e-9 Blood protein levels; CRC cis rs28655083 1.000 rs7197078 chr16:77072735 G/A cg01753188 chr16:77233325 SYCE1L;MON1B -0.54 -7.73 -0.39 1.32e-13 Lobe attachment (rater-scored or self-reported); CRC cis rs1552244 1.000 rs9824585 chr3:10114802 T/C cg00166722 chr3:10149974 C3orf24 0.66 9.0 0.44 1.85e-17 Alzheimer's disease; CRC cis rs12893668 0.542 rs12884809 chr14:104095320 G/A cg08213375 chr14:104286397 PPP1R13B 0.39 6.23 0.32 1.41e-9 Reticulocyte count; CRC cis rs1784581 0.588 rs1789986 chr6:162409978 C/T cg17173639 chr6:162384350 PARK2 -0.61 -9.84 -0.48 3.49e-20 Itch intensity from mosquito bite; CRC cis rs2066819 1.000 rs2291361 chr12:56717805 G/A cg26714650 chr12:56694279 CS -1.39 -11.42 -0.53 1.14e-25 Psoriasis vulgaris; CRC cis rs6951245 0.935 rs79067319 chr7:1065548 C/T cg07217954 chr7:1067459 C7orf50 0.56 5.75 0.3 2.07e-8 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs10193935 1.000 rs4494804 chr2:42395946 A/T cg27598129 chr2:42591480 NA -0.7 -7.9 -0.4 4.3e-14 Colonoscopy-negative controls vs population controls; CRC cis rs7201929 1.000 rs7201929 chr16:28871966 C/T cg10436792 chr16:28889110 ATP2A1 -0.41 -5.93 -0.31 7.72e-9 QT interval; CRC cis rs11105298 0.891 rs3741899 chr12:89933931 G/A cg00757033 chr12:89920650 WDR51B 0.38 6.28 0.33 1.06e-9 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; CRC cis rs1580019 0.844 rs1584615 chr7:32503258 G/C cg07520158 chr7:32535189 LSM5;AVL9 0.49 6.7 0.35 8.88e-11 Cognitive ability; CRC cis rs17270561 0.585 rs9393663 chr6:25741033 A/T cg16482183 chr6:26056742 HIST1H1C 0.83 10.69 0.51 4.46e-23 Iron status biomarkers; CRC trans rs11343 0.675 rs7359333 chr16:19262344 A/T cg25184248 chr3:123813393 KALRN 0.47 6.17 0.32 2.02e-9 Parkinson's disease; CRC cis rs910316 1.000 rs175425 chr14:75626131 T/C cg03030879 chr14:75389066 RPS6KL1 0.44 6.69 0.35 9.82e-11 Height; CRC cis rs10971721 0.822 rs72725368 chr9:33815455 G/A cg13495928 chr9:33750294 PRSS3 0.55 5.89 0.31 9.66e-9 Body mass index; CRC cis rs6496667 0.779 rs6496673 chr15:90976106 C/T cg04176472 chr15:90893244 GABARAPL3 0.59 7.97 0.4 2.62e-14 Rheumatoid arthritis; CRC cis rs1448094 0.817 rs10863112 chr12:86330844 C/T cg00310523 chr12:86230176 RASSF9 0.43 7.26 0.37 2.88e-12 Major depressive disorder; CRC cis rs7615952 0.576 rs12497295 chr3:125818650 G/A cg18479299 chr3:125709523 NA -0.55 -6.53 -0.34 2.45e-10 Blood pressure (smoking interaction); CRC cis rs136211 0.929 rs6000262 chr22:36770038 A/G cg16924664 chr22:36878180 TXN2 0.39 5.71 0.3 2.59e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs11628318 0.853 rs10151896 chr14:103039936 G/C cg23461800 chr14:103021989 NA -0.75 -10.23 -0.49 1.7e-21 Platelet count; CRC cis rs17270561 0.583 rs7765833 chr6:25712433 C/A cg17691542 chr6:26056736 HIST1H1C 0.64 8.53 0.43 5.53e-16 Iron status biomarkers; CRC cis rs13256369 1.000 rs12550762 chr8:8576535 T/A cg06671706 chr8:8559999 CLDN23 0.55 8.27 0.41 3.41e-15 Obesity-related traits; CRC cis rs427941 0.562 rs6950791 chr7:101780458 C/T cg06246474 chr7:101738831 CUX1 0.45 6.9 0.36 2.63e-11 Plasma omega-3 polyunsaturated fatty acid level (eicosapentaenoic acid); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg14777817 chr13:80055594 NDFIP2 0.46 7.42 0.38 1.01e-12 Liver disease severity in Alagille syndrome; CRC cis rs9527 0.571 rs7096249 chr10:104618524 G/A cg04362960 chr10:104952993 NT5C2 0.56 7.9 0.4 4.29e-14 Arsenic metabolism; CRC trans rs7824557 0.751 rs2099456 chr8:11127001 A/C cg06636001 chr8:8085503 FLJ10661 0.46 6.73 0.35 7.51e-11 Retinal vascular caliber; CRC cis rs7772486 0.875 rs1125461 chr6:146417653 C/T cg13319975 chr6:146136371 FBXO30 -0.4 -6.06 -0.32 3.81e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs2836974 0.568 rs2142111 chr21:40549289 G/C cg11644478 chr21:40555479 PSMG1 0.68 10.81 0.51 1.7e-23 Cognitive function; CRC trans rs783540 0.934 rs783532 chr15:83249367 C/T cg18393722 chr15:85113863 UBE2QP1 -0.37 -6.37 -0.33 6.54e-10 Schizophrenia; CRC cis rs72781680 0.898 rs72780121 chr2:23995918 T/C cg08917208 chr2:24149416 ATAD2B 0.86 8.35 0.42 1.86e-15 Lymphocyte counts; CRC cis rs7659604 0.935 rs73844280 chr4:122664687 G/A cg19748678 chr4:122722346 EXOSC9 0.54 8.67 0.43 2.05e-16 Type 2 diabetes; CRC cis rs4689388 0.853 rs13114527 chr4:6294655 T/G cg14416269 chr4:6271139 WFS1 0.4 6.59 0.34 1.72e-10 Type 2 diabetes and other traits;Type 2 diabetes; CRC cis rs2832191 0.716 rs9983051 chr21:30371890 C/T cg08807101 chr21:30365312 RNF160 0.71 11.51 0.54 5.4e-26 Dental caries; CRC cis rs9903692 0.954 rs68175794 chr17:46181104 G/T cg21215337 chr17:46176117 CBX1 -0.43 -7.95 -0.4 2.95e-14 Pulse pressure; CRC cis rs780094 0.564 rs4665978 chr2:27648726 T/C cg12000995 chr2:27665139 KRTCAP3 -0.29 -6.07 -0.32 3.51e-9 Calcium levels;Fasting blood insulin;Metabolic traits;Triglyceride levels;Fasting plasma glucose;Urate levels in overweight individuals;Urate levels in obese individuals;Uric acid levels;Height;Age-related diseases, mortality and associated endophenotypes;Renal underexcretion gout;Fasting blood glucose (BMI interaction);Urate levels;Gondoic acid (20:1n-9) levels;Fasting blood insulin (BMI interaction);Triglycerides;Plasma omega-3 polyunsaturated fatty acid levels (docosapentaenoic acid);Type 2 diabetes;Nonalcoholic fatty liver disease;Hypertriglyceridemia;C-reactive protein;Age-related disease endophenotypes;LDL cholesterol;Metabolic syndrome;Crohn's disease;Alcohol consumption (drinks per week);Homeostasis model assessment of insulin resistance;Alcohol consumption;Red blood cell count;Fasting blood glucose; CRC cis rs8180040 0.620 rs6442055 chr3:47110722 A/G cg10298567 chr3:47292165 KIF9 -0.4 -6.29 -0.33 9.96e-10 Colorectal cancer; CRC cis rs10504229 0.728 rs72650852 chr8:58150463 G/A cg02725872 chr8:58115012 NA -0.6 -9.12 -0.45 7.55e-18 Developmental language disorder (linguistic errors); CRC cis rs7586879 0.765 rs11683429 chr2:25120733 T/A cg04586622 chr2:25135609 ADCY3 -0.57 -9.72 -0.47 8.37e-20 Body mass index; CRC cis rs9318086 0.776 rs1326130 chr13:24447664 A/C cg25267304 chr13:24462978 PCOTH;MIPEP 0.58 9.28 0.46 2.37e-18 Myopia (pathological); CRC cis rs9291683 0.509 rs6849717 chr4:9958719 T/C cg11266682 chr4:10021025 SLC2A9 -0.52 -10.69 -0.51 4.39e-23 Bone mineral density; CRC cis rs2235642 0.717 rs9937922 chr16:1658154 C/G cg09065629 chr16:1709722 CRAMP1L 0.36 5.62 0.3 4.09e-8 Coronary artery disease; CRC cis rs669446 0.533 rs3791041 chr1:44202991 A/G cg12908607 chr1:44402522 ARTN -0.35 -5.93 -0.31 7.46e-9 Amyotrophic lateral sclerosis (age of onset); CRC cis rs1448094 0.511 rs10779210 chr12:86162432 T/C cg18827107 chr12:86230957 RASSF9 0.37 5.78 0.3 1.72e-8 Major depressive disorder; CRC cis rs1891498 0.516 rs12037169 chr1:147248057 A/G cg17941330 chr1:147245494 GJA5 -0.37 -5.64 -0.3 3.67e-8 Cognitive performance; CRC cis rs561341 0.882 rs28649357 chr17:30367190 A/G cg12193833 chr17:30244370 NA -0.62 -7.99 -0.4 2.27e-14 Hip circumference adjusted for BMI; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg19387228 chr4:8442570 ACOX3 0.51 7.41 0.38 1.05e-12 Response to antipsychotic treatment; CRC cis rs514406 0.505 rs395169 chr1:53174071 G/A cg24675658 chr1:53192096 ZYG11B -0.67 -10.11 -0.49 4.18e-21 Monocyte count; CRC cis rs2976388 0.609 rs2585148 chr8:143796193 C/G cg04969067 chr8:143858791 LYNX1 0.45 7.68 0.39 1.84e-13 Urinary tract infection frequency; CRC cis rs5758511 0.680 rs5758684 chr22:42649509 C/T cg00645731 chr22:42541494 CYP2D7P1 0.67 10.38 0.5 4.96e-22 Birth weight; CRC cis rs6951245 0.515 rs78461900 chr7:1007033 C/A cg24642844 chr7:1081250 C7orf50 -0.84 -7.41 -0.38 1.05e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs7811142 0.830 rs73401450 chr7:99981859 G/C cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.62 7.89 0.4 4.64e-14 Platelet count; CRC cis rs12711979 0.904 rs12329356 chr2:3868533 G/C cg17052675 chr2:3827356 NA -0.51 -9.22 -0.45 3.74e-18 Itch intensity from mosquito bite adjusted by bite size; CRC trans rs1814175 0.791 rs1722023 chr11:49908136 G/C cg15704280 chr7:45808275 SEPT13 -1.02 -20.57 -0.75 5.09e-61 Height; CRC cis rs9303401 0.646 rs9303403 chr17:57219300 C/T cg10487724 chr17:56770010 TEX14;RAD51C -0.43 -6.41 -0.33 5.19e-10 Cognitive test performance; CRC cis rs2179367 0.959 rs504985 chr6:149658978 T/G cg11245181 chr6:149772854 ZC3H12D -0.4 -6.08 -0.32 3.4e-9 Dupuytren's disease; CRC cis rs4819052 0.851 rs35064782 chr21:46674360 G/A cg11663144 chr21:46675770 NA -0.85 -14.8 -0.63 2.36e-38 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs9322193 0.884 rs9688858 chr6:149959047 C/A cg05861140 chr6:150128134 PCMT1 -0.42 -6.86 -0.35 3.4e-11 Lung cancer; CRC cis rs2153535 0.580 rs1932282 chr6:8477330 G/A cg07606381 chr6:8435919 SLC35B3 0.68 10.9 0.51 8.26e-24 Motion sickness; CRC cis rs10504229 0.906 rs112793785 chr8:58190537 T/C cg01721255 chr8:58191610 C8orf71 0.49 6.14 0.32 2.4e-9 Developmental language disorder (linguistic errors); CRC cis rs644799 1.000 rs586238 chr11:95560371 C/T cg25622487 chr11:95524042 FAM76B;CEP57 0.76 11.92 0.55 1.8e-27 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs7085104 0.700 rs6163 chr10:104596924 C/A cg04362960 chr10:104952993 NT5C2 0.6 8.94 0.44 2.9e-17 Immature fraction of reticulocytes;Schizophrenia; CRC cis rs10883723 0.810 rs7094366 chr10:104274730 C/G cg11453585 chr10:104263688 ACTR1A;SUFU 0.9 17.02 0.68 4.75e-47 Allergic disease (asthma, hay fever or eczema); CRC cis rs4843747 0.671 rs4072871 chr16:88106614 C/T cg07865391 chr16:88106882 BANP 0.47 6.09 0.32 3.1e-9 Menopause (age at onset); CRC cis rs7786808 0.505 rs67537656 chr7:158192646 C/T cg09998033 chr7:158218633 PTPRN2 0.51 7.27 0.37 2.72e-12 Obesity-related traits; CRC cis rs1904096 0.506 rs28522293 chr4:95167087 A/G cg11021082 chr4:95130006 SMARCAD1 -0.58 -9.07 -0.45 1.11e-17 Type 2 diabetes; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg25350635 chr12:49182847 ADCY6 0.39 6.39 0.33 5.76e-10 Liver disease severity in Alagille syndrome; CRC cis rs2011503 1.000 rs11670761 chr19:19649327 G/C cg11584989 chr19:19387371 SF4 0.58 6.47 0.34 3.47e-10 Bipolar disorder; CRC cis rs730566 1.000 rs4858819 chr3:48478088 C/T cg20833759 chr3:49053208 WDR6;DALRD3 -0.43 -6.07 -0.32 3.46e-9 Prion diseases; CRC cis rs2075371 1.000 rs2598296 chr7:133992985 C/T cg02659138 chr7:134003124 SLC35B4 0.39 6.68 0.35 1.02e-10 Mean platelet volume; CRC cis rs7605827 0.930 rs11687986 chr2:15591308 G/T cg19274914 chr2:15703543 NA 0.39 6.01 0.31 4.94e-9 Educational attainment (years of education); CRC cis rs1465370 0.720 rs5011387 chr7:130017149 C/T cg03229158 chr7:130009420 NA 0.44 6.26 0.33 1.23e-9 Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction);Waist circumference adjusted for BMI in active individuals;Waist circumference adjusted for body mass index; CRC trans rs7395662 1.000 rs11039890 chr11:48653468 C/G cg21153622 chr11:89784906 NA -0.48 -7.73 -0.39 1.35e-13 HDL cholesterol; CRC cis rs4689388 0.782 rs4262051 chr4:6281775 G/A cg00701064 chr4:6280414 WFS1 0.76 12.91 0.58 3.91e-31 Type 2 diabetes and other traits;Type 2 diabetes; CRC trans rs6956675 0.915 rs6977279 chr7:62630625 C/G cg01314568 chr7:57830625 NA -0.66 -9.15 -0.45 5.98e-18 Obesity-related traits; CRC cis rs7726839 0.561 rs72703044 chr5:579737 G/A cg16447950 chr5:562315 NA -0.85 -12.55 -0.57 8.97e-30 Obesity-related traits; CRC cis rs35264875 0.898 rs55648928 chr11:68861591 G/T cg01993067 chr11:68851601 TPCN2 0.58 6.66 0.34 1.13e-10 Blond vs. brown hair color; CRC cis rs7412746 0.658 rs72704685 chr1:150897687 C/G cg10589385 chr1:150898437 SETDB1 0.32 6.87 0.35 3.16e-11 Melanoma; CRC cis rs568617 1.000 rs656980 chr11:65656282 G/A cg19792802 chr11:65647270 CTSW 0.5 7.55 0.38 4.23e-13 Crohn's disease; CRC cis rs7945718 0.839 rs10831911 chr11:12834858 C/T cg25843174 chr11:12811716 TEAD1 0.5 9.32 0.46 1.77e-18 Educational attainment (years of education); CRC trans rs2727020 0.615 rs35423199 chr11:49514914 T/C cg15704280 chr7:45808275 SEPT13 -0.95 -18.43 -0.71 1.34e-52 Coronary artery disease; CRC cis rs7666738 0.791 rs11735105 chr4:98937357 C/T cg17366294 chr4:99064904 C4orf37 0.43 7.32 0.37 1.95e-12 Colonoscopy-negative controls vs population controls; CRC cis rs8177179 1.000 rs8177179 chr3:133463457 G/A cg16262614 chr3:133464971 TF 0.5 9.46 0.46 6.16e-19 Iron status biomarkers (transferrin levels); CRC cis rs7945705 0.783 rs11042125 chr11:8938049 A/T cg12365402 chr11:9010492 NRIP3 -0.51 -8.41 -0.42 1.28e-15 Hemoglobin concentration; CRC cis rs8058578 0.775 rs8046391 chr16:30836648 G/C cg00531865 chr16:30841666 NA -0.47 -6.4 -0.33 5.5e-10 Multiple myeloma; CRC cis rs826838 0.967 rs10875979 chr12:39095149 G/A cg13010199 chr12:38710504 ALG10B 0.42 5.84 0.31 1.23e-8 Heart rate; CRC cis rs2032447 0.869 rs2230655 chr6:26033506 A/G cg12588279 chr6:26043732 HIST1H2BB -0.49 -7.09 -0.36 8.06e-12 Intelligence (multi-trait analysis); CRC trans rs9825823 0.617 rs2083264 chr3:61074229 A/G cg08990514 chr17:48672483 CACNA1G -0.37 -6.26 -0.33 1.18e-9 Depressive symptom measurement or major depressive disorder; CRC cis rs1448094 0.511 rs4469976 chr12:86146723 T/C cg25456477 chr12:86230367 RASSF9 -0.36 -6.07 -0.32 3.43e-9 Major depressive disorder; CRC trans rs1814175 0.781 rs2866734 chr11:49886338 A/G cg11707556 chr5:10655725 ANKRD33B -0.44 -8.39 -0.42 1.42e-15 Height; CRC cis rs28386778 0.897 rs1062787 chr17:61896004 T/C cg07362569 chr17:61921086 SMARCD2 0.37 5.66 0.3 3.23e-8 Prudent dietary pattern; CRC cis rs12594515 1.000 rs7172161 chr15:45990780 A/G cg22117107 chr15:45993392 NA -0.44 -9.09 -0.45 9.56e-18 Waist circumference;Weight; CRC cis rs5769765 0.817 rs9616212 chr22:50317687 G/A cg02269571 chr22:50332266 NA -0.62 -7.7 -0.39 1.5700000000000001e-13 Schizophrenia; CRC cis rs72634258 0.945 rs161802 chr1:8042826 G/T cg00042356 chr1:8021962 PARK7 0.53 6.53 0.34 2.48e-10 Inflammatory bowel disease; CRC cis rs826838 0.967 rs11169387 chr12:39145737 C/T cg26384229 chr12:38710491 ALG10B 0.7 9.72 0.47 8.32e-20 Heart rate; CRC cis rs11203032 0.831 rs3923282 chr10:90946752 C/T cg16672925 chr10:90967113 CH25H 0.45 5.73 0.3 2.31e-8 Heart failure; CRC cis rs9322193 0.567 rs7747457 chr6:150213502 T/A cg07701084 chr6:150067640 NUP43 0.54 7.59 0.39 3.3e-13 Lung cancer; CRC cis rs1218582 0.628 rs12130132 chr1:154880386 C/T cg09359103 chr1:154839909 KCNN3 -0.7 -10.87 -0.51 1.03e-23 Prostate cancer; CRC cis rs6723226 0.732 rs390480 chr2:32510072 A/C cg02381751 chr2:32503542 YIPF4 -0.59 -8.69 -0.43 1.75e-16 Intelligence (multi-trait analysis); CRC cis rs35306767 0.623 rs56201968 chr10:1141666 A/G cg26597838 chr10:835615 NA 0.52 7.06 0.36 9.84e-12 Eosinophil percentage of granulocytes; CRC cis rs7769051 1.000 rs5006218 chr6:133126220 T/G cg07930552 chr6:133119739 C6orf192 0.66 8.17 0.41 6.84e-15 Type 2 diabetes nephropathy; CRC cis rs4665809 0.938 rs6742226 chr2:26342537 A/G cg04944784 chr2:26401820 FAM59B -0.6 -7.63 -0.39 2.58e-13 Gut microbiome composition (summer); CRC cis rs7605827 0.930 rs1019358 chr2:15524042 A/G cg19274914 chr2:15703543 NA 0.39 5.9 0.31 8.92e-9 Educational attainment (years of education); CRC cis rs561341 1.000 rs564714 chr17:30318404 C/T cg00745463 chr17:30367425 LRRC37B -0.88 -9.6 -0.47 2.1e-19 Hip circumference adjusted for BMI; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg14964934 chr19:4723942 DPP9 0.43 6.03 0.32 4.36e-9 Anxiety disorder; CRC cis rs4713118 0.869 rs4713121 chr6:27722064 T/C cg02683197 chr6:28174875 NA 0.68 8.32 0.42 2.36e-15 Parkinson's disease; CRC cis rs7727544 0.684 rs272849 chr5:131690241 A/G cg07395648 chr5:131743802 NA -0.41 -6.29 -0.33 1.03e-9 Blood metabolite levels; CRC cis rs2842992 0.789 rs9355748 chr6:160194882 G/A cg11366901 chr6:160182831 ACAT2 0.97 14.26 0.62 2.99e-36 Age-related macular degeneration (geographic atrophy); CRC cis rs7692995 1.000 rs1585333 chr4:18019025 T/C cg08925142 chr4:18023851 LCORL -0.51 -5.81 -0.3 1.5e-8 Height; CRC trans rs9354308 0.933 rs10455586 chr6:66571498 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.48 6.06 0.32 3.69e-9 Metabolite levels; CRC cis rs12980942 0.591 rs1946613 chr19:41767785 C/T cg25627403 chr19:41769009 HNRNPUL1 0.56 6.49 0.34 3.13e-10 Coronary artery disease; CRC cis rs17095355 1.000 rs12570230 chr10:111691614 T/C cg00817464 chr10:111662876 XPNPEP1 -0.6 -8.0 -0.4 2.1e-14 Biliary atresia; CRC cis rs896854 0.517 rs2013597 chr8:95951807 G/A cg16049864 chr8:95962084 TP53INP1 -0.47 -7.41 -0.38 1.1e-12 Type 2 diabetes; CRC cis rs7412746 0.611 rs10888391 chr1:150729983 G/A cg10589385 chr1:150898437 SETDB1 0.3 6.23 0.33 1.39e-9 Melanoma; CRC cis rs9847710 0.967 rs4687694 chr3:53049047 T/C cg04503182 chr3:53078218 SFMBT1 0.41 6.6 0.34 1.69e-10 Ulcerative colitis; CRC cis rs769267 0.965 rs1010207 chr19:19416045 T/C cg20644253 chr19:19431407 KIAA0892;SF4 0.42 5.77 0.3 1.85e-8 Tonsillectomy; CRC cis rs853679 0.546 rs200953 chr6:27837267 T/C cg26587870 chr6:27730563 NA -0.65 -6.65 -0.34 1.21e-10 Depression; CRC cis rs2522056 1.000 rs2706381 chr5:131810619 C/T cg24060327 chr5:131705240 SLC22A5 0.41 5.76 0.3 1.96e-8 Lymphocyte counts;Fibrinogen; CRC cis rs12230513 0.732 rs61957765 chr12:55868561 T/C cg19537932 chr12:55886519 OR6C68 -0.72 -9.15 -0.45 6.05e-18 Contrast sensitivity; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg02977761 chr19:42901279 NA 0.43 6.64 0.34 1.33e-10 Intelligence (multi-trait analysis); CRC cis rs3026445 0.761 rs67917264 chr12:110554818 A/G cg12870014 chr12:110450643 ANKRD13A 0.43 6.91 0.36 2.5e-11 QT interval; CRC cis rs73200209 0.744 rs61562746 chr12:116456445 A/C cg01776926 chr12:116560359 MED13L -0.63 -7.37 -0.38 1.4e-12 Total body bone mineral density; CRC cis rs9786986 0.609 rs12401387 chr1:235701314 C/T cg08848088 chr1:235714526 GNG4 0.52 6.4 0.33 5.2400000000000005e-10 Body mass index; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg16365086 chr5:150603689 CCDC69 0.45 6.33 0.33 7.87e-10 Response to antipsychotic treatment; CRC cis rs9309711 0.544 rs9752130 chr2:3488502 A/G cg15541040 chr2:3486749 NA -0.53 -8.4 -0.42 1.35e-15 Neurofibrillary tangles; CRC cis rs6570726 0.791 rs407887 chr6:145843759 C/T cg23711669 chr6:146136114 FBXO30 0.74 12.89 0.58 4.51e-31 Lobe attachment (rater-scored or self-reported); CRC cis rs2762353 0.935 rs3757130 chr6:25770866 C/T cg12310025 chr6:25882481 NA 0.5 7.44 0.38 8.89e-13 Blood metabolite levels; CRC cis rs6570726 0.599 rs455001 chr6:145854450 A/T cg23711669 chr6:146136114 FBXO30 0.62 9.26 0.45 2.68e-18 Lobe attachment (rater-scored or self-reported); CRC cis rs2481665 0.772 rs12730782 chr1:62537265 A/G cg18591186 chr1:62594603 INADL -0.52 -7.13 -0.37 6.25e-12 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs62432291 0.614 rs420339 chr6:159657195 G/T cg14500486 chr6:159655392 FNDC1 -0.77 -10.43 -0.5 3.48e-22 Joint mobility (Beighton score); CRC cis rs4930103 0.782 rs10840167 chr11:2022023 G/T cg06197492 chr11:2016605 H19 0.42 6.48 0.34 3.29e-10 DNA methylation (parent-of-origin);DNA methylation (variation); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg07560096 chr11:86383182 ME3 0.42 5.98 0.31 5.72e-9 Response to antipsychotic treatment; CRC cis rs2836974 0.568 rs452377 chr21:40537183 T/C cg11644478 chr21:40555479 PSMG1 0.73 12.3 0.56 7.53e-29 Cognitive function; CRC cis rs12048904 0.647 rs7528268 chr1:101329295 A/G cg15686842 chr1:101360669 SLC30A7;EXTL2 0.6 8.11 0.41 9.98e-15 Multiple sclerosis; CRC cis rs4862750 0.915 rs6835681 chr4:187903476 A/G cg03452623 chr4:187889614 NA -0.9 -20.29 -0.75 6.11e-60 Lobe attachment (rater-scored or self-reported); CRC cis rs7546668 0.652 rs12691551 chr1:15907908 C/G cg05141711 chr1:15912213 AGMAT 0.33 5.9 0.31 9.02e-9 Glomerular filtration rate (creatinine); CRC cis rs6912958 0.535 rs1753153 chr6:88032834 T/G cg08069147 chr6:88032118 GJB7;C6orf162 0.74 12.06 0.55 5.66e-28 Monocyte percentage of white cells; CRC cis rs6586163 1.000 rs7097572 chr10:90753260 A/G cg03111039 chr10:90751583 FAS;ACTA2 -0.52 -7.44 -0.38 9.09e-13 Chronic lymphocytic leukemia; CRC cis rs365302 1.000 rs416321 chr6:159648907 C/T cg14500486 chr6:159655392 FNDC1 0.44 6.82 0.35 4.31e-11 Coronary heart disease; CRC cis rs9807989 0.839 rs1420099 chr2:102980543 C/G cg03938978 chr2:103052716 IL18RAP 0.37 6.1 0.32 3.01e-9 Asthma; CRC cis rs6860806 0.507 rs272868 chr5:131680751 C/G cg07395648 chr5:131743802 NA -0.4 -5.66 -0.3 3.27e-8 Breast cancer; CRC cis rs10927875 0.562 rs10803401 chr1:16147377 G/A cg21385522 chr1:16154831 NA -1.09 -19.31 -0.73 4.6e-56 Dilated cardiomyopathy; CRC trans rs2303319 0.504 rs56371522 chr2:162491109 G/A cg10272801 chr16:14013773 ERCC4 -0.69 -6.06 -0.32 3.8e-9 Cognitive function; CRC trans rs4714291 0.832 rs1923462 chr6:39976100 T/C cg02267698 chr19:7991119 CTXN1 -0.5 -6.82 -0.35 4.25e-11 Strep throat; CRC cis rs6504950 0.800 rs12952253 chr17:53005716 A/G cg26251398 chr17:52985966 TOM1L1 0.4 5.66 0.3 3.24e-8 Breast cancer; CRC cis rs617791 0.508 rs2276132 chr11:65770545 G/A cg27068330 chr11:65405492 SIPA1 -0.48 -6.69 -0.35 9.69e-11 Breast cancer; CRC trans rs9929218 0.861 rs8056206 chr16:68802072 G/C cg04657470 chr2:198365150 HSPE1;HSPD1 -0.83 -11.83 -0.55 3.66e-27 Colorectal cancer; CRC cis rs2727020 0.521 rs10839285 chr11:49496852 T/G cg25886479 chr11:50257625 LOC441601 0.36 6.23 0.32 1.4e-9 Coronary artery disease; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg09611793 chr4:48833193 OCIAD1 0.38 5.98 0.31 5.77e-9 Liver disease severity in Alagille syndrome; CRC trans rs9650657 0.537 rs7016385 chr8:10779472 A/G cg06636001 chr8:8085503 FLJ10661 0.59 8.43 0.42 1.12e-15 Neuroticism; CRC cis rs738322 0.870 rs5750558 chr22:38582497 G/A cg25457927 chr22:38595422 NA 0.44 9.41 0.46 8.85e-19 Cutaneous nevi; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg20913372 chr9:140190455 NA 0.45 6.33 0.33 8.22e-10 Response to antipsychotic treatment; CRC cis rs35110281 0.744 rs230646 chr21:44918788 A/G cg01579765 chr21:45077557 HSF2BP -0.33 -5.99 -0.31 5.62e-9 Mean corpuscular volume; CRC cis rs561341 0.941 rs2428338 chr17:30299629 T/C cg19193384 chr17:30244184 NA -0.53 -6.89 -0.36 2.85e-11 Hip circumference adjusted for BMI; CRC cis rs10504229 1.000 rs114312649 chr8:58182539 C/G cg22535103 chr8:58192502 C8orf71 -0.82 -12.27 -0.56 9.63e-29 Developmental language disorder (linguistic errors); CRC cis rs11098499 0.954 rs10034623 chr4:120397829 G/A cg24375607 chr4:120327624 NA 0.49 7.63 0.39 2.49e-13 Corneal astigmatism; CRC cis rs769267 0.965 rs2074303 chr19:19381755 C/T cg01262667 chr19:19385393 TM6SF2 0.36 5.87 0.31 1.06e-8 Tonsillectomy; CRC cis rs651907 0.513 rs34963630 chr3:101504817 C/T cg11279151 chr3:101281821 RG9MTD1 -0.52 -6.89 -0.36 2.84e-11 Colorectal cancer; CRC cis rs6570726 0.693 rs450921 chr6:145864260 C/T cg13319975 chr6:146136371 FBXO30 -0.46 -6.84 -0.35 3.9e-11 Lobe attachment (rater-scored or self-reported); CRC cis rs9916302 0.706 rs1874226 chr17:37729031 C/T cg15445000 chr17:37608096 MED1 -0.36 -6.18 -0.32 1.86e-9 Glomerular filtration rate (creatinine); CRC cis rs7197653 0.748 rs2279538 chr16:68397106 C/G cg09835421 chr16:68378352 PRMT7 -0.78 -8.1 -0.41 1.12e-14 Magnesium levels; CRC cis rs72634258 0.519 rs4908487 chr1:7937437 C/T cg26816564 chr1:7831052 VAMP3 0.78 8.68 0.43 1.81e-16 Inflammatory bowel disease; CRC cis rs1881797 0.872 rs12404733 chr1:247690417 A/C cg18198730 chr1:247681584 NA 0.53 8.57 0.43 4.16e-16 Acute lymphoblastic leukemia (childhood); CRC cis rs4713118 0.662 rs9468276 chr6:28027688 A/C cg03623178 chr6:28175578 NA 0.92 12.95 0.58 2.82e-31 Parkinson's disease; CRC cis rs1005277 0.540 rs4934907 chr10:38015230 A/C cg25427524 chr10:38739819 LOC399744 -0.73 -12.72 -0.57 1.94e-30 Extrinsic epigenetic age acceleration; CRC cis rs4604732 0.812 rs6663238 chr1:247624971 C/T cg02104434 chr1:247694406 LOC148824;OR2C3 -0.41 -6.24 -0.33 1.34e-9 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CRC cis rs10751667 0.666 rs7396059 chr11:970490 C/A ch.11.42038R chr11:967971 AP2A2 0.57 9.76 0.47 6.46e-20 Alzheimer's disease (late onset); CRC cis rs4808199 0.894 rs10418051 chr19:19397789 C/T cg03709012 chr19:19516395 GATAD2A 0.89 11.17 0.52 9e-25 Nonalcoholic fatty liver disease; CRC cis rs9322193 0.923 rs10747276 chr6:150079875 G/A cg07701084 chr6:150067640 NUP43 0.59 8.89 0.44 4.18e-17 Lung cancer; CRC cis rs3790645 1.000 rs897641 chr1:26881806 C/A cg17456097 chr1:26900765 RPS6KA1 0.41 6.16 0.32 2.08e-9 Glucose homeostasis traits; CRC cis rs9916302 0.706 rs4795385 chr17:37733148 A/G cg00129232 chr17:37814104 STARD3 0.6 7.21 0.37 3.94e-12 Glomerular filtration rate (creatinine); CRC trans rs916888 0.531 rs183211 chr17:44788310 G/A cg22968622 chr17:43663579 NA 0.88 11.78 0.54 5.62e-27 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs7524258 0.900 rs6577426 chr1:7306451 A/G cg07173049 chr1:7289937 CAMTA1 0.53 8.6 0.43 3.32e-16 Tourette's syndrome or obsessive-compulsive disorder; CRC cis rs6700896 0.864 rs11208718 chr1:66158995 G/A cg04111102 chr1:66153794 NA 0.34 5.87 0.31 1.04e-8 C-reactive protein;Mean corpuscular volume;Mean corpuscular hemoglobin; CRC cis rs57221529 0.766 rs12522140 chr5:587261 C/A cg16447950 chr5:562315 NA -0.81 -10.62 -0.51 7.76e-23 Lung disease severity in cystic fibrosis; CRC cis rs9462027 0.561 rs3798348 chr6:34771892 C/G cg07306190 chr6:34760872 UHRF1BP1 -0.34 -6.07 -0.32 3.47e-9 Systemic lupus erythematosus; CRC cis rs12477438 0.734 rs4851184 chr2:99666434 T/C cg14399236 chr2:99771627 LIPT1;TSGA10 -0.74 -10.37 -0.5 5.51e-22 Chronic sinus infection; CRC cis rs1799949 0.965 rs11080034 chr17:41443014 T/C cg19454999 chr17:41278357 BRCA1;NBR2 0.4 6.18 0.32 1.9e-9 Menopause (age at onset); CRC cis rs997295 0.570 rs7172298 chr15:67872983 T/C cg24247231 chr15:67904302 MAP2K5 -0.33 -5.62 -0.3 4.16e-8 Motion sickness; CRC cis rs7493 1.000 rs2040993 chr7:95047300 T/A cg19678392 chr7:94953810 PON1 -0.56 -7.06 -0.36 9.89e-12 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs9322193 0.847 rs9383844 chr6:150037404 T/C cg07701084 chr6:150067640 NUP43 0.61 9.1 0.45 8.96e-18 Lung cancer; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg00129774 chr12:56360414 CDK2;SILV 0.41 6.03 0.32 4.32e-9 Intelligence (multi-trait analysis); CRC cis rs7666738 0.830 rs28485415 chr4:99060340 G/A cg05340658 chr4:99064831 C4orf37 0.61 9.47 0.46 5.5e-19 Colonoscopy-negative controls vs population controls; CRC cis rs3026101 0.671 rs2107151 chr17:5297338 G/T cg25236894 chr17:5323110 RPAIN;NUP88 0.43 6.91 0.36 2.49e-11 Body mass index; CRC cis rs7945718 0.967 rs2241857 chr11:12815831 C/T cg25843174 chr11:12811716 TEAD1 -0.48 -8.82 -0.44 6.68e-17 Educational attainment (years of education); CRC cis rs1552244 1.000 rs17032396 chr3:10153559 A/G cg08888203 chr3:10149979 C3orf24 -0.67 -9.06 -0.45 1.17e-17 Alzheimer's disease; CRC cis rs344364 0.511 rs1742462 chr16:1946062 A/C cg00046913 chr16:1877150 HAGH;FAHD1 -0.56 -5.92 -0.31 7.93e-9 Glomerular filtration rate in chronic kidney disease; CRC cis rs1862618 0.641 rs2591954 chr5:56245044 G/C cg12311346 chr5:56204834 C5orf35 0.64 9.72 0.47 8.47e-20 Initial pursuit acceleration; CRC cis rs17270561 0.609 rs1318016 chr6:25764704 A/T cg16482183 chr6:26056742 HIST1H1C 0.71 9.0 0.44 1.79e-17 Iron status biomarkers; CRC cis rs853679 0.517 rs17711344 chr6:28077602 A/G cg18032046 chr6:28092343 ZSCAN16 0.49 5.65 0.3 3.5e-8 Depression; CRC cis rs34172651 0.917 rs2112786 chr16:24778944 C/T cg00339695 chr16:24857497 SLC5A11 0.28 6.6 0.34 1.61e-10 Intelligence (multi-trait analysis); CRC trans rs1455244 0.700 rs7229302 chr18:11508904 G/T cg08592733 chr4:140374542 RAB33B 0.43 6.26 0.33 1.23e-9 Schizophrenia; CRC cis rs11785400 0.793 rs11785376 chr8:143730412 C/T cg24634471 chr8:143751801 JRK 0.52 7.15 0.37 5.69e-12 Schizophrenia; CRC cis rs34779708 0.966 rs34296409 chr10:35404613 C/G cg03585969 chr10:35415529 CREM 0.66 8.73 0.43 1.33e-16 Inflammatory bowel disease;Crohn's disease; CRC cis rs3820068 0.554 rs60233444 chr1:15921330 A/C cg27534772 chr1:16042836 PLEKHM2 0.53 10.02 0.48 8.15e-21 Systolic blood pressure; CRC cis rs13108904 0.901 rs13124847 chr4:1278206 A/G cg16405210 chr4:1374714 KIAA1530 -0.46 -6.34 -0.33 7.54e-10 Obesity-related traits; CRC trans rs6472235 0.837 rs10098417 chr8:66918380 A/G cg07884673 chr3:53033167 SFMBT1 -0.46 -6.15 -0.32 2.31e-9 Myopia (pathological);Plateletcrit; CRC cis rs9926296 0.533 rs12102297 chr16:89812762 C/A cg21285383 chr16:89894308 SPIRE2 0.34 5.64 0.3 3.73e-8 Vitiligo; CRC cis rs7618501 0.633 rs13060128 chr3:50025028 A/G cg24308560 chr3:49941425 MST1R -0.53 -9.0 -0.44 1.8e-17 Intelligence (multi-trait analysis); CRC cis rs9858542 1.000 rs9882740 chr3:49702484 T/C cg03060546 chr3:49711283 APEH -0.53 -7.23 -0.37 3.32e-12 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs4319547 0.695 rs11057797 chr12:122860732 G/A cg05707623 chr12:122985044 ZCCHC8 0.78 9.46 0.46 6.15e-19 Body mass index; CRC cis rs1055129 0.584 rs9895947 chr17:73908566 A/C cg08125733 chr17:73851984 WBP2 0.47 6.0 0.31 5.15e-9 White matter hyperintensity burden; CRC cis rs10746514 0.833 rs867844 chr1:232266278 A/T cg09506761 chr1:232265262 NA 0.47 6.74 0.35 6.94e-11 Response to statin therapy; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg02056921 chr1:901892 PLEKHN1 0.48 6.39 0.33 5.72e-10 Thyroid stimulating hormone; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg15531788 chr10:38146671 ZNF248 0.42 6.92 0.36 2.35e-11 Liver disease severity in Alagille syndrome; CRC cis rs9914988 0.537 rs28448745 chr17:27188296 A/C cg12682573 chr17:27188876 MIR451;MIR144 -0.52 -7.01 -0.36 1.37e-11 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs881375 0.900 rs2241003 chr9:123666777 G/C cg09419670 chr9:123605666 PSMD5;LOC253039 0.5 7.45 0.38 8.19e-13 Rheumatoid arthritis; CRC trans rs747334 0.558 rs7897249 chr10:92772368 C/T cg05202497 chr5:154317929 GEMIN5 0.53 6.3 0.33 9.57e-10 Fibroblast growth factor basic levels; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg06056004 chr5:44809616 MRPS30 0.49 6.42 0.33 4.86e-10 Thyroid stimulating hormone; CRC cis rs55871839 0.708 rs2326213 chr8:59812459 A/G cg07426533 chr8:59803705 TOX -0.34 -5.94 -0.31 7.22e-9 Pneumonia; CRC cis rs6557786 0.636 rs2445940 chr8:24787201 C/G cg20585869 chr8:24772333 NEFM 0.37 5.8 0.3 1.58e-8 Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 2 peripheral neuropathy); CRC cis rs1005277 0.540 rs2145487 chr10:38010077 A/G cg25517755 chr10:38738941 LOC399744 -0.44 -6.48 -0.34 3.27e-10 Extrinsic epigenetic age acceleration; CRC cis rs6586163 0.872 rs7069841 chr10:90741955 T/C cg03111039 chr10:90751583 FAS;ACTA2 -0.5 -7.08 -0.36 8.67e-12 Chronic lymphocytic leukemia; CRC cis rs2019137 0.560 rs11123172 chr2:113984303 C/T cg07772999 chr2:113993052 PAX8;LOC440839;LOC654433 -0.55 -8.28 -0.42 3.17e-15 Lymphocyte counts; CRC cis rs4409675 0.576 rs6662916 chr1:28219873 G/T cg11176159 chr1:28213800 NA 0.3 5.8 0.3 1.56e-8 Corneal astigmatism; CRC cis rs10870270 1.000 rs10870271 chr10:133754807 A/G cg17892150 chr10:133769511 PPP2R2D 0.72 11.1 0.52 1.56e-24 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; CRC cis rs2692947 0.794 rs2692949 chr2:96673525 G/A cg23100626 chr2:96804247 ASTL 0.25 6.73 0.35 7.51e-11 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; CRC cis rs9556958 0.635 rs4529985 chr13:99167120 G/C cg15168958 chr13:99100528 FARP1 0.38 6.2 0.32 1.67e-9 Educational attainment (years of education); CRC cis rs1775148 1 rs1775148 chr1:205757824 C/T cg14893161 chr1:205819251 PM20D1 0.41 6.1 0.32 2.92e-9 Prostate cancer; CRC trans rs2243480 1.000 rs57057549 chr7:65405738 A/G cg10756647 chr7:56101905 PSPH 0.71 7.57 0.39 3.91e-13 Diabetic kidney disease; CRC cis rs1046896 0.503 rs12947062 chr17:80686370 A/G cg02398342 chr17:80708632 TBCD;FN3K -0.35 -5.65 -0.3 3.41e-8 Glycated hemoglobin levels; CRC cis rs7208859 0.623 rs77544470 chr17:28934550 C/A cg13385521 chr17:29058706 SUZ12P 0.62 6.66 0.34 1.13e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs7586879 0.616 rs6726199 chr2:25126328 G/C cg04586622 chr2:25135609 ADCY3 -0.54 -10.01 -0.48 9.31e-21 Body mass index; CRC cis rs11758351 0.715 rs75390741 chr6:26209784 A/T cg01420254 chr6:26195488 NA 0.79 8.84 0.44 6.05e-17 Gout;Renal underexcretion gout; CRC cis rs12971120 0.947 rs8084109 chr18:72168312 T/A cg25817165 chr18:72167213 CNDP2 -0.66 -11.52 -0.54 4.87e-26 Refractive error; CRC cis rs1048238 0.846 rs945419 chr1:16344858 C/T cg22431228 chr1:16359049 CLCNKA -0.43 -8.26 -0.41 3.48e-15 Systolic blood pressure; CRC cis rs6534441 0.727 rs78433352 chr4:125458401 A/G cg21609808 chr4:125404261 NA 0.41 5.76 0.3 1.95e-8 Major depressive disorder; CRC cis rs9916302 0.861 rs8081033 chr17:37506650 A/G cg07936489 chr17:37558343 FBXL20 0.84 13.09 0.59 8.21e-32 Glomerular filtration rate (creatinine); CRC cis rs4481887 1.000 rs6666690 chr1:248465323 T/C cg00666640 chr1:248458726 OR2T12 0.52 9.29 0.46 2.23e-18 Common traits (Other); CRC cis rs4713118 0.513 rs149955 chr6:28036225 G/C cg12172441 chr6:28176163 NA 0.51 6.99 0.36 1.58e-11 Parkinson's disease; CRC trans rs2303319 0.504 rs12470743 chr2:162611202 G/A cg22902534 chr3:183892754 AP2M1 -0.7 -6.1 -0.32 2.96e-9 Cognitive function; CRC cis rs1949733 0.701 rs2688222 chr4:8473735 C/A cg13073564 chr4:8508604 NA -0.47 -7.08 -0.36 8.99e-12 Response to antineoplastic agents; CRC cis rs8044868 0.530 rs2288000 chr16:72058881 A/G cg23815491 chr16:72088622 HP 0.47 6.95 0.36 1.94e-11 Body mass index (change over time) in cancer or chronic obstructive pulmonary disease;Body mass index (change over time) in cancer; CRC cis rs3741404 0.560 rs17699798 chr11:63898806 C/G cg19465662 chr11:63993652 NUDT22;TRPT1 -0.66 -10.25 -0.49 1.43e-21 Platelet count; CRC cis rs2279817 1.000 rs2279815 chr1:18022066 G/T cg21791023 chr1:18019539 ARHGEF10L 0.53 6.52 0.34 2.7e-10 Neuroticism; CRC cis rs12410462 1.000 rs80168344 chr1:227655804 C/T cg23173402 chr1:227635558 NA 0.7 7.91 0.4 3.83e-14 Major depressive disorder; CRC cis rs4664293 0.647 rs10202352 chr2:160427608 G/A cg08347373 chr2:160653686 CD302 -0.38 -6.41 -0.33 4.95e-10 Monocyte percentage of white cells; CRC cis rs798554 0.757 rs1182171 chr7:2878510 A/G cg19717773 chr7:2847554 GNA12 -0.48 -6.98 -0.36 1.68e-11 Height; CRC cis rs798554 0.797 rs798497 chr7:2795957 A/G cg13628971 chr7:2884303 GNA12 0.52 7.21 0.37 3.82e-12 Height; CRC cis rs853679 0.517 rs35193936 chr6:28076270 A/G cg03623178 chr6:28175578 NA 0.95 12.46 0.57 1.93e-29 Depression; CRC cis rs1218582 0.741 rs11264291 chr1:154914797 C/T cg06221963 chr1:154839813 KCNN3 -0.77 -15.11 -0.64 1.52e-39 Prostate cancer; CRC cis rs7224685 0.501 rs6502765 chr17:3901814 A/G cg09597638 chr17:3907349 NA 0.71 13.19 0.59 3.41e-32 Type 2 diabetes; CRC cis rs8077889 0.956 rs61608877 chr17:41848713 A/C cg16892393 chr17:41919603 NA 0.4 5.92 0.31 7.88e-9 Triglycerides; CRC cis rs5750830 0.569 rs5750809 chr22:39791491 T/G cg05872129 chr22:39784769 NA -0.59 -10.59 -0.5 9.39e-23 Intelligence (multi-trait analysis); CRC cis rs11031096 0.542 rs11030404 chr11:3980638 T/C cg18678763 chr11:4115507 RRM1 -0.41 -6.85 -0.35 3.61e-11 Mean corpuscular volume;Mean corpuscular hemoglobin; CRC cis rs10479542 0.583 rs4131080 chr5:179044292 G/A cg26516362 chr5:178986906 RUFY1 0.34 5.83 0.31 1.31e-8 Lung cancer; CRC cis rs748404 0.631 rs2467745 chr15:43722742 A/G cg15269541 chr15:43626905 ADAL -0.36 -5.64 -0.3 3.7e-8 Lung cancer; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg14383135 chr2:101436923 NPAS2 -0.4 -6.17 -0.32 2.03e-9 Myopia (pathological); CRC cis rs8063761 0.589 rs4238833 chr16:90050689 G/T cg25193494 chr16:90016004 DEF8 0.48 7.37 0.38 1.38e-12 Squamous cell carcinoma; CRC cis rs8060686 0.623 rs28700885 chr16:68154544 A/G cg26727032 chr16:67993705 SLC12A4 -0.62 -9.66 -0.47 1.32e-19 HDL cholesterol;Metabolic syndrome; CRC cis rs9768139 0.708 rs921616 chr7:158117960 A/G cg23298862 chr7:158159286 PTPRN2 0.38 5.98 0.31 5.8e-9 Calcium levels; CRC cis rs9420 0.890 rs547891 chr11:57499065 C/T cg23127183 chr11:57508653 C11orf31 0.53 7.47 0.38 7.36e-13 Schizophrenia; CRC cis rs7223966 1.000 rs8070650 chr17:61744040 A/G cg05941027 chr17:61774174 LIMD2 0.37 6.71 0.35 8.59e-11 Hip circumference adjusted for BMI;Body mass index; CRC cis rs4713118 0.527 rs35949862 chr6:28115367 A/G cg02683197 chr6:28174875 NA 0.87 10.73 0.51 3.25e-23 Parkinson's disease; CRC cis rs4481887 0.962 rs6587452 chr1:248485931 C/T cg13385794 chr1:248469461 NA 0.39 6.68 0.35 1.01e-10 Common traits (Other); CRC cis rs11123610 0.520 rs12711962 chr2:3717985 C/T cg10645314 chr2:3704589 ALLC -0.54 -6.32 -0.33 8.33e-10 Response to inhaled corticosteroid treatment in asthma (change in FEV1); CRC cis rs3741404 0.584 rs645461 chr11:63893694 C/T cg14078730 chr11:63896557 MACROD1 -0.35 -5.63 -0.3 3.83e-8 Platelet count; CRC cis rs10242455 0.571 rs45532337 chr7:99310319 A/G cg18809830 chr7:99032528 PTCD1 -0.87 -6.82 -0.35 4.39e-11 Blood metabolite levels; CRC trans rs2228479 0.702 rs2074903 chr16:89811663 T/C cg24644049 chr4:85504048 CDS1 0.9 7.46 0.38 7.69e-13 Skin colour saturation; CRC cis rs1499614 1.000 rs1267817 chr7:66110040 G/T cg25985355 chr7:65971099 NA -0.52 -5.93 -0.31 7.51e-9 Gout; CRC cis rs7772486 0.719 rs702307 chr6:145993454 C/G cg13319975 chr6:146136371 FBXO30 0.42 6.19 0.32 1.81e-9 Lobe attachment (rater-scored or self-reported); CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg03038816 chr19:49149549 SEC1;CA11 0.51 6.51 0.34 2.84e-10 Thyroid stimulating hormone; CRC cis rs9649213 0.511 rs6950994 chr7:97887872 G/A cg21770322 chr7:97807741 LMTK2 0.58 9.64 0.47 1.56e-19 Prostate cancer (SNP x SNP interaction); CRC cis rs798554 0.797 rs798493 chr7:2798731 A/G cg13628971 chr7:2884303 GNA12 0.52 6.94 0.36 2.14e-11 Height; CRC cis rs1728785 1.000 rs1645938 chr16:68595197 G/A cg02972257 chr16:68554789 NA -0.6 -7.54 -0.38 4.71e-13 Ulcerative colitis; CRC cis rs875971 1.000 rs1968225 chr7:65874773 T/C cg00343986 chr7:65444356 GUSB 0.43 6.3 0.33 9.66e-10 Aortic root size; CRC cis rs68170813 0.523 rs7777976 chr7:106888594 C/T cg02696742 chr7:106810147 HBP1 -0.6 -6.65 -0.34 1.25e-10 Coronary artery disease; CRC cis rs11212617 0.967 rs2356802 chr11:108282169 A/G cg01991180 chr11:108092276 ATM;NPAT 0.43 6.51 0.34 2.74e-10 Response to metformin in type 2 diabetes (glycemic); CRC cis rs9292777 0.897 rs6883964 chr5:40411910 A/G cg09067459 chr5:40385259 NA 0.51 8.86 0.44 5.15e-17 Crohn's disease;Multiple sclerosis; CRC cis rs6502050 0.835 rs4789675 chr17:80123144 G/A cg25804541 chr17:80189381 SLC16A3 -0.31 -5.95 -0.31 6.84e-9 Life satisfaction; CRC cis rs6570726 0.577 rs867056 chr6:145784805 A/C cg05347473 chr6:146136440 FBXO30 -0.46 -6.72 -0.35 8.16e-11 Lobe attachment (rater-scored or self-reported); CRC cis rs10540 1.000 rs61876333 chr11:487136 G/A cg19913688 chr11:428466 ANO9 -0.74 -7.16 -0.37 5.3e-12 Body mass index; CRC trans rs2243480 1.000 rs465359 chr7:65558164 C/T cg10756647 chr7:56101905 PSPH 0.69 7.49 0.38 6.21e-13 Diabetic kidney disease; CRC cis rs929354 0.685 rs7807856 chr7:156934498 T/C cg05182265 chr7:156933206 UBE3C -0.76 -14.38 -0.62 1.04e-36 Body mass index; CRC cis rs561341 0.941 rs112569713 chr17:30271738 C/T cg19193384 chr17:30244184 NA -0.53 -6.66 -0.34 1.15e-10 Hip circumference adjusted for BMI; CRC cis rs7789940 0.809 rs12533836 chr7:75935622 G/T cg10167463 chr7:75959203 YWHAG -0.66 -9.12 -0.45 7.82e-18 Multiple sclerosis; CRC cis rs1552244 1.000 rs34179822 chr3:10140017 A/G cg02579736 chr3:10068473 FANCD2;CIDECP 0.92 12.66 0.57 3.43e-30 Alzheimer's disease; CRC cis rs4731207 0.596 rs10255638 chr7:124576255 C/T cg23710748 chr7:124431027 NA 0.39 6.14 0.32 2.42e-9 Cutaneous malignant melanoma; CRC cis rs2072499 0.966 rs2853641 chr1:156181770 A/G cg24450063 chr1:156163899 SLC25A44 1.1 24.82 0.81 2.18e-77 Testicular germ cell tumor; CRC cis rs9916302 0.800 rs8081220 chr17:37473157 A/C cg03013999 chr17:37608204 MED1 -0.47 -7.03 -0.36 1.18e-11 Glomerular filtration rate (creatinine); CRC cis rs9951602 0.703 rs2959407 chr18:76682915 A/G cg00806245 chr18:76673096 NA -0.43 -6.12 -0.32 2.68e-9 Obesity-related traits; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg12830829 chr14:51707081 TMX1 -0.42 -6.04 -0.32 4.21e-9 Myopia (pathological); CRC cis rs11122272 0.668 rs1122131 chr1:231476501 A/G cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.49 -7.27 -0.37 2.61e-12 Hemoglobin concentration; CRC cis rs1552244 1.000 rs6807846 chr3:10134491 G/T cg00166722 chr3:10149974 C3orf24 0.65 8.87 0.44 4.92e-17 Alzheimer's disease; CRC cis rs6754459 0.603 rs11894441 chr2:3701972 A/G cg19052272 chr2:3704530 ALLC 0.5 7.04 0.36 1.14e-11 Response to inhaled corticosteroid treatment in asthma (change in FEV1); CRC cis rs2860975 0.905 rs10786182 chr10:96789775 C/T cg09036531 chr10:96991505 NA -0.47 -6.31 -0.33 8.9e-10 Immune response to smallpox vaccine (IL-6); CRC cis rs6952808 0.595 rs3800916 chr7:2166072 C/T cg22963979 chr7:1858916 MAD1L1 -0.43 -6.19 -0.32 1.76e-9 Bipolar disorder and schizophrenia; CRC cis rs3849570 0.555 rs4452351 chr3:82007977 C/T cg07356753 chr3:81810745 GBE1 -0.5 -6.94 -0.36 2.07e-11 Waist circumference;Body mass index; CRC cis rs425277 1.000 rs12401379 chr1:2058580 G/C cg24578937 chr1:2090814 PRKCZ 0.67 11.72 0.54 9.53e-27 Height; CRC cis rs7618501 0.966 rs13063621 chr3:49821625 T/C cg24308560 chr3:49941425 MST1R -0.45 -7.01 -0.36 1.33e-11 Intelligence (multi-trait analysis); CRC cis rs6831352 0.819 rs2851274 chr4:100025866 G/C cg13256891 chr4:100009986 ADH5 0.55 7.85 0.4 5.74e-14 Alcohol dependence; CRC trans rs2727020 0.729 rs6485965 chr11:49166730 C/T cg11707556 chr5:10655725 ANKRD33B 0.37 6.72 0.35 7.94e-11 Coronary artery disease; CRC cis rs877282 0.898 rs11253339 chr10:759640 C/T cg17470449 chr10:769945 NA 0.64 8.41 0.42 1.26e-15 Uric acid levels; CRC cis rs10927875 0.691 rs1048261 chr1:16340951 A/T cg24140574 chr1:16342155 HSPB7 0.42 5.67 0.3 3.09e-8 Dilated cardiomyopathy; CRC cis rs9649213 0.593 rs34534766 chr7:97920871 G/C cg24562669 chr7:97807699 LMTK2 0.45 7.52 0.38 5.11e-13 Prostate cancer (SNP x SNP interaction); CRC cis rs10789491 1.000 rs12794 chr1:47141718 T/C cg15501359 chr1:47185051 KIAA0494 0.64 7.89 0.4 4.4e-14 Response to hepatitis C treatment; CRC cis rs561341 0.830 rs7218801 chr17:30217778 A/G cg12193833 chr17:30244370 NA 0.55 6.88 0.35 2.98e-11 Hip circumference adjusted for BMI; CRC cis rs3096299 0.967 rs28575874 chr16:89469890 C/T cg01788221 chr16:89496183 ANKRD11 -0.47 -7.26 -0.37 2.9e-12 Multiple myeloma (IgH translocation); CRC cis rs4862750 0.872 rs6553030 chr4:187899234 T/C cg03647317 chr4:187891568 NA -0.54 -10.28 -0.49 1.09e-21 Lobe attachment (rater-scored or self-reported); CRC cis rs6424115 1.000 rs7514394 chr1:24100223 A/G cg09473613 chr1:24152604 HMGCL -0.34 -5.88 -0.31 1.03e-8 Immature fraction of reticulocytes; CRC cis rs1005277 0.557 rs176887 chr10:38406094 T/C cg17219203 chr10:38645113 HSD17B7P2 -0.41 -5.76 -0.3 1.97e-8 Extrinsic epigenetic age acceleration; CRC cis rs11628318 0.563 rs4906234 chr14:103076928 G/C cg12046867 chr14:103022105 NA -0.44 -5.82 -0.31 1.38e-8 Platelet count; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg16974379 chr10:38146505 ZNF248 0.51 7.28 0.37 2.41e-12 Response to antipsychotic treatment; CRC trans rs1973993 0.662 rs6593607 chr1:96968116 G/A cg10631902 chr5:14652156 NA -0.41 -6.81 -0.35 4.61e-11 Weight; CRC cis rs7703744 0.634 rs73237292 chr5:118688520 A/T cg02283238 chr5:118691126 TNFAIP8 0.45 6.28 0.33 1.08e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs2153535 0.580 rs1119690 chr6:8460660 G/A cg21535247 chr6:8435926 SLC35B3 0.5 7.55 0.38 4.28e-13 Motion sickness; CRC cis rs3733585 0.673 rs4467564 chr4:9953472 G/T cg00071950 chr4:10020882 SLC2A9 -0.55 -9.74 -0.47 7.09e-20 Cleft plate (environmental tobacco smoke interaction); CRC cis rs2737618 0.722 rs2816978 chr1:200078773 A/G cg21825944 chr1:200113062 NR5A2 -0.48 -6.62 -0.34 1.49e-10 Uric acid levels; CRC cis rs10504229 0.683 rs73603877 chr8:58108428 C/T cg21724239 chr8:58056113 NA 0.52 6.97 0.36 1.79e-11 Developmental language disorder (linguistic errors); CRC cis rs77972916 0.609 rs72790907 chr2:43575195 C/T cg06169590 chr2:43455088 ZFP36L2;LOC100129726 -0.63 -5.66 -0.3 3.33e-8 Granulocyte percentage of myeloid white cells; CRC cis rs9640161 0.658 rs60467296 chr7:150015471 G/A cg12556325 chr7:150026731 C7orf29;LRRC61 -0.42 -6.29 -0.33 1.03e-9 Blood protein levels;Circulating chemerin levels; CRC cis rs9527 0.641 rs34130454 chr10:104903638 A/G cg04362960 chr10:104952993 NT5C2 0.6 8.32 0.42 2.32e-15 Arsenic metabolism; CRC cis rs798554 0.797 rs1182174 chr7:2875420 G/A cg19717773 chr7:2847554 GNA12 -0.49 -7.1 -0.36 7.57e-12 Height; CRC trans rs12599106 0.648 rs12447240 chr16:34928236 C/T cg01171360 chr6:293285 DUSP22 0.56 8.11 0.41 1.01e-14 Menopause (age at onset); CRC cis rs2204008 0.654 rs1733410 chr12:38132172 G/A cg13010199 chr12:38710504 ALG10B -0.41 -5.99 -0.31 5.54e-9 Bladder cancer; CRC cis rs2836974 0.613 rs2245455 chr21:40548087 A/T cg11890956 chr21:40555474 PSMG1 -0.81 -13.09 -0.59 8.69e-32 Cognitive function; CRC cis rs9399135 1.000 rs4475342 chr6:135283348 T/C cg24558204 chr6:135376177 HBS1L 0.48 7.34 0.38 1.64e-12 Red blood cell count; CRC cis rs4731207 0.596 rs1531718 chr7:124644777 T/A cg23710748 chr7:124431027 NA -0.39 -6.16 -0.32 2.17e-9 Cutaneous malignant melanoma; CRC cis rs875971 0.862 rs10282433 chr7:65721439 G/A cg18252515 chr7:66147081 NA 0.4 5.73 0.3 2.21e-8 Aortic root size; CRC cis rs9916302 0.904 rs2024073 chr17:37471330 T/G cg07936489 chr17:37558343 FBXL20 0.78 11.69 0.54 1.26e-26 Glomerular filtration rate (creatinine); CRC cis rs13191362 0.872 rs35443919 chr6:163055804 C/T cg06582575 chr6:163149167 PACRG;PARK2 0.93 11.5 0.54 5.69e-26 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs62103177 0.525 rs4799116 chr18:77736735 A/G cg20368463 chr18:77673604 PQLC1 -0.58 -6.56 -0.34 2.05e-10 Opioid sensitivity; CRC cis rs3815700 1.000 rs7260624 chr19:33096562 A/G cg02997394 chr19:33096574 ANKRD27 0.77 9.08 0.45 1.02e-17 Eosinophilic esophagitis; CRC cis rs561341 0.883 rs4450460 chr17:30201309 C/T cg12193833 chr17:30244370 NA 0.55 6.85 0.35 3.57e-11 Hip circumference adjusted for BMI; CRC cis rs9875589 0.509 rs2731330 chr3:14111588 C/G cg14375111 chr3:14165186 TMEM43;CHCHD4 0.41 6.01 0.31 4.87e-9 Ovarian reserve; CRC cis rs853679 0.517 rs9380056 chr6:28104476 C/T cg02683197 chr6:28174875 NA 0.85 10.52 0.5 1.71e-22 Depression; CRC cis rs4654899 0.965 rs6692081 chr1:21296363 T/C cg02927042 chr1:21476669 EIF4G3 -0.48 -7.78 -0.39 9.4e-14 Superior frontal gyrus grey matter volume; CRC cis rs7264396 0.790 rs6058297 chr20:34271861 G/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.62 -10.41 -0.5 3.95e-22 Total cholesterol levels; CRC cis rs853679 0.517 rs9468298 chr6:28122345 A/G cg02683197 chr6:28174875 NA 0.87 10.73 0.51 3.25e-23 Depression; CRC cis rs7107174 1.000 rs10793308 chr11:78086005 C/T cg02023728 chr11:77925099 USP35 0.43 7.15 0.37 5.79e-12 Testicular germ cell tumor; CRC cis rs4862750 0.914 rs1346126 chr4:187876404 T/C cg07414643 chr4:187882934 NA 0.39 6.86 0.35 3.35e-11 Lobe attachment (rater-scored or self-reported); CRC cis rs1799949 0.628 rs4474733 chr17:41433660 G/T cg05368731 chr17:41323189 NBR1 0.62 8.29 0.42 2.98e-15 Menopause (age at onset); CRC cis rs9549328 0.800 rs9549617 chr13:113628070 C/A cg25790453 chr13:113633590 MCF2L -0.57 -10.02 -0.48 8.77e-21 Systolic blood pressure; CRC cis rs7309 0.935 rs6432674 chr2:162025322 G/T cg16506815 chr2:162101123 NA 0.51 8.53 0.43 5.36e-16 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Educational attainment; CRC cis rs2976388 0.609 rs2263092 chr8:143789966 A/G cg22687807 chr8:143858763 LYNX1 0.51 9.19 0.45 4.69e-18 Urinary tract infection frequency; CRC cis rs11098499 0.909 rs28714195 chr4:120316950 A/T cg24375607 chr4:120327624 NA 0.5 7.74 0.39 1.22e-13 Corneal astigmatism; CRC cis rs4900538 0.963 rs1190553 chr14:102915331 G/T cg18135206 chr14:102964638 TECPR2 -0.97 -19.27 -0.73 6.27e-56 Mean corpuscular volume;Mean corpuscular hemoglobin; CRC cis rs7659604 0.689 rs59131059 chr4:122666357 C/T cg20573242 chr4:122745356 CCNA2 0.43 6.31 0.33 8.9e-10 Type 2 diabetes; CRC cis rs929354 0.651 rs6951298 chr7:156949149 T/C cg17757837 chr7:157058334 UBE3C 0.74 12.39 0.56 3.31e-29 Body mass index; CRC cis rs7119 0.667 rs2867312 chr15:77902293 A/G cg10437265 chr15:77819839 NA 0.46 8.12 0.41 9.66e-15 Type 2 diabetes; CRC cis rs6860806 0.507 rs272872 chr5:131675864 C/T cg22638593 chr5:131593259 PDLIM4 -0.35 -5.87 -0.31 1.08e-8 Breast cancer; CRC trans rs7618501 0.633 rs11130228 chr3:50003246 C/T cg21659725 chr3:3221576 CRBN 0.54 8.53 0.43 5.26e-16 Intelligence (multi-trait analysis); CRC cis rs2797160 0.967 rs1739368 chr6:126011079 C/T cg05901451 chr6:126070800 HEY2 0.41 6.2 0.32 1.66e-9 Endometrial cancer; CRC cis rs300703 0.872 rs428697 chr2:213302 G/A cg21211680 chr2:198530 NA 1.0 9.15 0.45 5.97e-18 Blood protein levels; CRC cis rs9393692 0.905 rs7747133 chr6:26293470 C/T cg05868516 chr6:26286170 HIST1H4H 0.39 5.72 0.3 2.41e-8 Educational attainment; CRC cis rs3617 0.573 rs6795646 chr3:52922621 C/T cg07507251 chr3:52567010 NT5DC2 -0.38 -5.84 -0.31 1.24e-8 Red blood cell count;Autism spectrum disorder or schizophrenia; CRC cis rs6066835 1.000 rs3746819 chr20:47307934 A/G cg18078177 chr20:47281410 PREX1 0.78 6.04 0.32 4.27e-9 Multiple myeloma; CRC cis rs5753618 0.607 rs5753621 chr22:31847647 T/C cg22777020 chr22:31556080 RNF185 0.48 5.88 0.31 9.99e-9 Colorectal cancer; CRC cis rs11148252 0.553 rs7999849 chr13:53249414 A/G cg12458913 chr13:53173898 NA 0.76 13.97 0.61 3.98e-35 Lewy body disease; CRC cis rs7618501 0.933 rs3811695 chr3:49761613 C/T cg24308560 chr3:49941425 MST1R 0.47 7.37 0.38 1.42e-12 Intelligence (multi-trait analysis); CRC cis rs12135062 1.000 rs12135062 chr1:3103312 A/C cg25382214 chr1:3105252 PRDM16 0.4 6.53 0.34 2.48e-10 Migraine; CRC cis rs72627123 0.867 rs59675549 chr14:74469480 A/T cg12022184 chr14:74485813 ENTPD5;C14orf45 0.71 5.89 0.31 9.77e-9 Morning vs. evening chronotype; CRC cis rs2836974 0.863 rs6517519 chr21:40540245 A/G cg11890956 chr21:40555474 PSMG1 1.08 19.02 0.72 5.97e-55 Cognitive function; CRC cis rs6456156 0.524 rs6934043 chr6:167466449 C/T cg07741184 chr6:167504864 NA 0.39 6.89 0.35 2.93e-11 Primary biliary cholangitis; CRC cis rs4970988 0.640 rs7524734 chr1:150655686 C/T cg17724175 chr1:150552817 MCL1 0.58 9.4 0.46 9.25e-19 Urate levels; CRC cis rs5769765 0.955 rs6520066 chr22:50294988 C/T cg22709217 chr22:50311962 ALG12;CRELD2 -0.9 -14.17 -0.62 6.71e-36 Schizophrenia; CRC cis rs10504229 0.683 rs56235637 chr8:58106008 T/C cg22535103 chr8:58192502 C8orf71 -0.69 -8.8 -0.44 7.79e-17 Developmental language disorder (linguistic errors); CRC cis rs2239547 0.657 rs2276817 chr3:52860936 C/T cg10802521 chr3:52805072 NEK4 -0.45 -6.0 -0.31 5.32e-9 Schizophrenia; CRC cis rs3126085 0.935 rs12063165 chr1:152176357 C/T cg09127314 chr1:152161683 NA 0.5 6.36 0.33 6.64e-10 Atopic dermatitis; CRC cis rs7772486 0.713 rs2328704 chr6:146020494 T/C cg23711669 chr6:146136114 FBXO30 -0.66 -11.08 -0.52 1.82e-24 Lobe attachment (rater-scored or self-reported); CRC cis rs1555322 0.530 rs6060341 chr20:33863633 C/T cg03689076 chr20:33865952 NA -0.56 -7.52 -0.38 5.2e-13 Attention deficit hyperactivity disorder; CRC cis rs875971 0.862 rs7803416 chr7:65954199 A/G cg18912574 chr7:65842487 NCRNA00174 0.36 6.1 0.32 2.99e-9 Aortic root size; CRC cis rs6502050 0.805 rs6502061 chr17:80086158 C/T cg22110888 chr17:80059540 CCDC57 -0.41 -6.46 -0.34 3.81e-10 Life satisfaction; CRC cis rs801193 0.935 rs3800820 chr7:66147178 C/T cg18876405 chr7:65276391 NA -0.61 -10.65 -0.51 5.71e-23 Aortic root size; CRC cis rs6740322 0.895 rs10196095 chr2:43571885 G/A cg06169590 chr2:43455088 ZFP36L2;LOC100129726 -0.65 -7.84 -0.4 6.43e-14 Coronary artery disease; CRC cis rs4481887 0.927 rs4350233 chr1:248489994 G/A cg13385794 chr1:248469461 NA 0.38 6.66 0.34 1.14e-10 Common traits (Other); CRC cis rs7044106 0.791 rs735110 chr9:123488940 T/A cg09419670 chr9:123605666 PSMD5;LOC253039 0.77 12.44 0.57 2.26e-29 Hip circumference adjusted for BMI; CRC trans rs2303319 0.504 rs55925603 chr2:162497210 G/A cg01191114 chr3:48936118 SLC25A20 -0.67 -6.08 -0.32 3.35e-9 Cognitive function; CRC cis rs9640161 0.750 rs73170185 chr7:150030191 C/A cg12556325 chr7:150026731 C7orf29;LRRC61 -0.51 -7.66 -0.39 2.07e-13 Blood protein levels;Circulating chemerin levels; CRC cis rs9640161 0.617 rs56019796 chr7:150009226 T/C cg13722127 chr7:150037890 RARRES2 0.45 7.7 0.39 1.62e-13 Blood protein levels;Circulating chemerin levels; CRC cis rs4474465 0.607 rs4945303 chr11:78283803 A/G cg27205649 chr11:78285834 NARS2 0.52 6.94 0.36 2.06e-11 Alzheimer's disease (survival time); CRC cis rs1862618 0.853 rs6885541 chr5:56110857 G/C cg18230493 chr5:56204884 C5orf35 -0.74 -9.38 -0.46 1.14e-18 Initial pursuit acceleration; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg21097105 chr17:19265900 B9D1 0.42 7.03 0.36 1.21e-11 Liver disease severity in Alagille syndrome; CRC trans rs2243480 1.000 rs313832 chr7:65550891 G/T cg10756647 chr7:56101905 PSPH 0.68 7.3 0.37 2.14e-12 Diabetic kidney disease; CRC cis rs12410462 1.000 rs76233861 chr1:227673909 G/A cg23173402 chr1:227635558 NA 0.64 7.09 0.36 8.38e-12 Major depressive disorder; CRC cis rs9467773 0.525 rs1535274 chr6:26520747 A/C cg09904177 chr6:26538194 HMGN4 0.74 11.31 0.53 2.74e-25 Intelligence (multi-trait analysis); CRC trans rs66573146 0.831 rs73088564 chr4:6984553 G/C cg07817883 chr1:32538562 TMEM39B 1.33 12.72 0.57 2.04e-30 Granulocyte percentage of myeloid white cells; CRC cis rs9457247 0.765 rs9459838 chr6:167426599 C/G cg23791538 chr6:167370224 RNASET2 -0.39 -5.9 -0.31 9.14e-9 Crohn's disease; CRC cis rs58804349 0.685 rs9422448 chr10:43288816 A/G cg15903213 chr10:43522190 NA -0.74 -5.75 -0.3 2.01e-8 Pediatric bone mineral content (radius); CRC cis rs7589728 0.563 rs78168096 chr2:88473575 G/A cg07952391 chr2:88470173 THNSL2 0.62 6.19 0.32 1.8e-9 Plasma clusterin levels; CRC trans rs4714291 0.722 rs9296320 chr6:40118298 C/G cg02267698 chr19:7991119 CTXN1 0.44 6.09 0.32 3.19e-9 Strep throat; CRC cis rs798554 0.660 rs2527692 chr7:2856533 G/A cg19717773 chr7:2847554 GNA12 -0.48 -8.13 -0.41 8.78e-15 Height; CRC cis rs11650494 0.710 rs2233666 chr17:47484286 T/C cg08112188 chr17:47440006 ZNF652 0.91 7.24 0.37 3.19e-12 Prostate cancer; CRC cis rs10461617 0.617 rs79742142 chr5:56104377 A/G cg18230493 chr5:56204884 C5orf35 -0.75 -9.49 -0.46 4.75e-19 Type 2 diabetes; CRC cis rs9322193 0.884 rs62439836 chr6:149990309 A/G cg13206674 chr6:150067644 NUP43 0.64 9.58 0.47 2.48e-19 Lung cancer; CRC cis rs4665809 0.525 rs4665324 chr2:26447147 A/C cg25036284 chr2:26402008 FAM59B -0.62 -7.86 -0.4 5.64e-14 Gut microbiome composition (summer); CRC cis rs875971 0.528 rs801213 chr7:66014918 C/T cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.55 -7.11 -0.37 7.2e-12 Aortic root size; CRC cis rs9926296 0.568 rs4420527 chr16:89814188 C/T cg03388025 chr16:89894329 SPIRE2 -0.42 -8.28 -0.42 3.18e-15 Vitiligo; CRC cis rs2692947 0.537 rs11685849 chr2:96243804 C/A cg23100626 chr2:96804247 ASTL 0.23 5.69 0.3 2.84e-8 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; CRC cis rs9311676 0.656 rs55668308 chr3:58388453 C/T cg06643156 chr3:58380774 PXK 0.41 6.33 0.33 7.82e-10 Systemic lupus erythematosus; CRC cis rs56104184 0.775 rs55756106 chr19:49403055 A/G cg21252483 chr19:49399788 TULP2 -0.43 -6.52 -0.34 2.59e-10 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; CRC cis rs727505 0.954 rs7789055 chr7:124677543 G/T cg23710748 chr7:124431027 NA -0.79 -13.66 -0.6 5.72e-34 Lewy body disease; CRC cis rs748404 0.723 rs560134 chr15:43555699 A/T cg02155558 chr15:43621948 ADAL;LCMT2 0.43 6.44 0.33 4.12e-10 Lung cancer; CRC cis rs9814567 0.896 rs11915964 chr3:134348930 A/C cg06109529 chr3:134205091 CEP63;ANAPC13 0.67 9.68 0.47 1.19e-19 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs9916302 0.904 rs2338797 chr17:37548241 G/A cg00129232 chr17:37814104 STARD3 0.53 7.94 0.4 3.23e-14 Glomerular filtration rate (creatinine); CRC cis rs9341808 0.754 rs9352808 chr6:80997342 G/T cg08355045 chr6:80787529 NA 0.35 5.7 0.3 2.69e-8 Sitting height ratio; CRC cis rs589448 0.902 rs528974 chr12:69765918 A/T cg20891283 chr12:69753455 YEATS4 0.98 21.22 0.76 1.46e-63 Cerebrospinal fluid biomarker levels; CRC cis rs1862618 0.671 rs2591957 chr5:56243146 A/T cg03609598 chr5:56110824 MAP3K1 0.58 7.81 0.4 7.56e-14 Initial pursuit acceleration; CRC cis rs4819052 0.808 rs2246697 chr21:46689999 G/A cg11663144 chr21:46675770 NA -0.85 -14.55 -0.63 2.21e-37 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs6951245 0.572 rs11559183 chr7:1037025 C/A cg20603222 chr7:1096387 C7orf50;GPR146 -0.7 -5.73 -0.3 2.28e-8 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs10752881 0.775 rs2147585 chr1:183074875 C/T ch.1.3577855R chr1:183094577 LAMC1 0.87 15.46 0.65 6.33e-41 Colorectal cancer; CRC cis rs11098499 0.909 rs71614422 chr4:120359340 G/A cg24375607 chr4:120327624 NA 0.51 7.95 0.4 3e-14 Corneal astigmatism; CRC cis rs1862618 0.853 rs861283 chr5:56184610 C/T cg03609598 chr5:56110824 MAP3K1 -0.85 -10.06 -0.49 6.18e-21 Initial pursuit acceleration; CRC trans rs7615952 0.512 rs2979334 chr3:125358824 G/A cg03844506 chr4:4109441 NA -0.51 -7.57 -0.39 3.88e-13 Blood pressure (smoking interaction); CRC cis rs6582630 0.502 rs11520279 chr12:38360871 A/G cg13010199 chr12:38710504 ALG10B 0.47 6.43 0.33 4.6e-10 Drug-induced liver injury (flucloxacillin); CRC cis rs3796352 1.000 rs36090694 chr3:53010742 T/C cg07884673 chr3:53033167 SFMBT1 0.73 5.87 0.31 1.04e-8 Immune reponse to smallpox (secreted IL-2); CRC cis rs950169 0.881 rs62029599 chr15:84956565 A/C cg17507749 chr15:85114479 UBE2QP1 0.74 10.59 0.5 9.91e-23 Schizophrenia; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg03861200 chr5:133340900 VDAC1 0.45 5.99 0.31 5.53e-9 Thyroid stimulating hormone; CRC cis rs9467711 0.559 rs3799383 chr6:26510748 C/T cg12315302 chr6:26189340 HIST1H4D 0.75 6.33 0.33 7.88e-10 Autism spectrum disorder or schizophrenia; CRC cis rs9902453 0.874 rs62070271 chr17:28268358 C/G cg26525008 chr17:28256777 EFCAB5;SSH2 0.7 11.54 0.54 4.14e-26 Coffee consumption (cups per day); CRC cis rs2243480 0.901 rs12530490 chr7:65691647 G/A cg12463550 chr7:65579703 CRCP -0.68 -6.04 -0.32 4.07e-9 Diabetic kidney disease; CRC cis rs7615952 0.599 rs7631268 chr3:125755664 T/A cg06494592 chr3:125709126 NA -0.55 -6.43 -0.33 4.43e-10 Blood pressure (smoking interaction); CRC cis rs6960043 0.714 rs6976086 chr7:15048611 T/G cg19272540 chr7:15055459 NA 0.23 6.27 0.33 1.13e-9 Type 2 diabetes; CRC cis rs1862618 0.853 rs1862619 chr5:56098256 T/A cg20203395 chr5:56204925 C5orf35 -0.59 -6.9 -0.36 2.63e-11 Initial pursuit acceleration; CRC cis rs4713118 0.539 rs200967 chr6:27862127 A/G cg25164649 chr6:28176230 NA 0.58 8.02 0.4 1.86e-14 Parkinson's disease; CRC trans rs61931739 0.500 rs6488224 chr12:34537205 T/C cg13010199 chr12:38710504 ALG10B 0.45 6.52 0.34 2.65e-10 Morning vs. evening chronotype; CRC cis rs8064299 0.967 rs3744208 chr17:72767565 A/G cg21922841 chr17:72744131 SLC9A3R1 0.28 5.86 0.31 1.13e-8 Monocyte count; CRC cis rs4253772 0.591 rs6008362 chr22:46652737 G/A cg24881330 chr22:46731750 TRMU 0.57 6.81 0.35 4.78e-11 LDL cholesterol;Cholesterol, total; CRC cis rs2749592 1.000 rs2749592 chr10:38258842 A/C cg25427524 chr10:38739819 LOC399744 -0.6 -8.86 -0.44 4.97e-17 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs2836974 0.863 rs12483216 chr21:40539614 T/C cg06238570 chr21:40685208 BRWD1 0.75 10.49 0.5 2.08e-22 Cognitive function; CRC cis rs599083 0.569 rs685095 chr11:68170376 C/T cg01657329 chr11:68192670 LRP5 0.47 6.79 0.35 5.37e-11 Bone mineral density (spine); CRC cis rs7258465 0.931 rs1560119 chr19:18573675 A/G cg06462663 chr19:18546047 ISYNA1 0.48 7.39 0.38 1.21e-12 Breast cancer; CRC cis rs4713118 0.586 rs9468290 chr6:28087674 C/T cg15845792 chr6:28175446 NA 1.0 13.1 0.59 7.81e-32 Parkinson's disease; CRC cis rs798554 0.686 rs2527690 chr7:2854250 C/T cg04166393 chr7:2884313 GNA12 0.38 5.82 0.31 1.4e-8 Height; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg16523653 chr20:31350394 DNMT3B 0.43 6.08 0.32 3.29e-9 Anxiety disorder; CRC cis rs9916302 0.904 rs8076546 chr17:37555403 G/A cg03013999 chr17:37608204 MED1 -0.47 -7.21 -0.37 3.87e-12 Glomerular filtration rate (creatinine); CRC cis rs7927771 0.832 rs6485753 chr11:47410200 C/T cg18512352 chr11:47633146 NA 0.39 7.37 0.38 1.4e-12 Subjective well-being; CRC trans rs35391 1.000 rs35391 chr5:33955673 C/T cg25815124 chr19:18434238 LSM4 0.7 6.24 0.33 1.34e-9 Tanning; CRC cis rs9322193 0.887 rs3777949 chr6:149917157 G/A cg07701084 chr6:150067640 NUP43 0.53 7.68 0.39 1.83e-13 Lung cancer; CRC cis rs7259376 0.875 rs10409520 chr19:22512477 C/T cg02657401 chr19:22469223 NA -0.37 -8.08 -0.41 1.23e-14 Menopause (age at onset); CRC cis rs17376456 1.000 rs67150649 chr5:93292377 A/G cg25358565 chr5:93447407 FAM172A 1.1 10.7 0.51 3.99e-23 Diabetic retinopathy; CRC cis rs9814567 1.000 rs4367113 chr3:134287975 G/A cg06109529 chr3:134205091 CEP63;ANAPC13 -0.83 -12.34 -0.56 5.38e-29 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs7523050 1.000 rs7523050 chr1:109417679 C/A cg08274380 chr1:109419600 GPSM2 0.53 5.82 0.31 1.41e-8 Fat distribution (HIV); CRC cis rs597539 0.652 rs501799 chr11:68631240 G/T cg21963583 chr11:68658836 MRPL21 0.56 10.25 0.49 1.41e-21 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs1046896 0.627 rs7225515 chr17:80795783 C/T cg03160526 chr17:80928410 B3GNTL1 0.57 7.68 0.39 1.81e-13 Glycated hemoglobin levels; CRC cis rs910316 0.967 rs35446981 chr14:75637351 A/T cg08847533 chr14:75593920 NEK9 -0.93 -17.24 -0.69 6.74e-48 Height; CRC cis rs1691799 0.867 rs6581677 chr12:66770379 C/G cg16791601 chr12:66731901 HELB -0.65 -11.04 -0.52 2.48e-24 White blood cell count (basophil); CRC trans rs10504229 1.000 rs56255635 chr8:58178264 T/C cg04077850 chr5:125800366 GRAMD3 0.37 6.27 0.33 1.15e-9 Developmental language disorder (linguistic errors); CRC cis rs2380220 0.576 rs7751219 chr6:96018915 G/A cg23517279 chr6:96025343 MANEA 0.55 6.23 0.33 1.4e-9 Behavioural disinhibition (generation interaction); CRC cis rs1552244 0.572 rs68013239 chr3:10165711 G/T cg00166722 chr3:10149974 C3orf24 0.65 7.7 0.39 1.56e-13 Alzheimer's disease; CRC cis rs7208859 0.623 rs12103508 chr17:29086781 T/G cg01831904 chr17:28903510 LRRC37B2 -0.63 -6.53 -0.34 2.51e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs6951245 1.000 rs1881123 chr7:1084706 C/T cg08132940 chr7:1081526 C7orf50 -0.54 -5.67 -0.3 3.04e-8 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs9611565 0.592 rs5751129 chr22:42015765 C/T cg03806693 chr22:41940476 POLR3H 0.7 8.95 0.44 2.64e-17 Vitiligo; CRC cis rs10464366 0.544 rs34866559 chr7:39166071 G/A cg20302533 chr7:39170763 POU6F2 0.42 5.7 0.3 2.74e-8 IgG glycosylation; CRC cis rs9311676 0.632 rs11130646 chr3:58447013 C/G cg06643156 chr3:58380774 PXK 0.44 6.78 0.35 5.59e-11 Systemic lupus erythematosus; CRC cis rs6502050 0.835 rs55679819 chr17:80105450 C/T cg25804541 chr17:80189381 SLC16A3 -0.3 -5.89 -0.31 9.4e-9 Life satisfaction; CRC cis rs7216064 1.000 rs59950564 chr17:65860859 A/G cg12091567 chr17:66097778 LOC651250 -0.68 -7.87 -0.4 5.31e-14 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CRC cis rs10504229 0.683 rs2291765 chr8:58142874 C/T cg24829409 chr8:58192753 C8orf71 -0.5 -7.62 -0.39 2.66e-13 Developmental language disorder (linguistic errors); CRC cis rs10504229 0.683 rs11775568 chr8:58133762 G/A cg02725872 chr8:58115012 NA -0.58 -8.39 -0.42 1.5e-15 Developmental language disorder (linguistic errors); CRC cis rs4481887 0.508 rs7349159 chr1:248386242 C/T cg00666640 chr1:248458726 OR2T12 0.38 6.09 0.32 3.21e-9 Common traits (Other); CRC cis rs9467711 0.606 rs12174639 chr6:26373121 G/A cg16898833 chr6:26189333 HIST1H4D 0.76 6.58 0.34 1.9e-10 Autism spectrum disorder or schizophrenia; CRC cis rs873946 0.564 rs35831787 chr10:134546346 T/C cg27286337 chr10:134555280 INPP5A 0.71 9.39 0.46 1e-18 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CRC cis rs7937682 1.000 rs10789843 chr11:111576158 C/T cg19812747 chr11:111475976 SIK2 0.53 8.43 0.42 1.1e-15 Primary sclerosing cholangitis; CRC cis rs9486715 0.867 rs9486444 chr6:96963619 A/G cg06623918 chr6:96969491 KIAA0776 1.03 20.52 0.75 7.72e-61 Headache; CRC cis rs3741404 0.825 rs7111753 chr11:63942189 A/G cg19465662 chr11:63993652 NUDT22;TRPT1 0.85 13.87 0.61 9.07e-35 Platelet count; CRC cis rs9393692 0.905 rs989134 chr6:26336224 A/C cg00631329 chr6:26305371 NA -0.69 -13.43 -0.59 4.53e-33 Educational attainment; CRC cis rs10504073 0.647 rs62507245 chr8:50006939 A/T cg00325661 chr8:49890786 NA 0.53 9.48 0.46 5.15e-19 Blood metabolite ratios; CRC cis rs6502050 0.635 rs11867440 chr17:80147185 A/T cg13198984 chr17:80129470 CCDC57 0.43 7.56 0.38 3.92e-13 Life satisfaction; CRC cis rs13191362 1.000 rs67646369 chr6:163003233 T/C cg21926612 chr6:163149169 PACRG;PARK2 0.8 11.25 0.53 4.59e-25 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs6743376 0.556 rs3180235 chr2:113820672 C/T cg24553058 chr2:113831203 IL1F10 -0.42 -6.99 -0.36 1.57e-11 Inflammatory biomarkers; CRC cis rs4664293 0.867 rs1126842 chr2:160627317 C/G cg08347373 chr2:160653686 CD302 -0.47 -7.43 -0.38 9.32e-13 Monocyte percentage of white cells; CRC cis rs11971779 0.680 rs11760420 chr7:139114768 C/T cg23387468 chr7:139079360 LUC7L2 0.41 7.04 0.36 1.14e-11 Diisocyanate-induced asthma; CRC cis rs5750830 0.649 rs5750811 chr22:39793066 G/T cg05872129 chr22:39784769 NA 0.6 10.66 0.51 5.67e-23 Intelligence (multi-trait analysis); CRC trans rs10838798 0.563 rs2870080 chr11:48144224 G/A cg21153622 chr11:89784906 NA -0.42 -6.55 -0.34 2.22e-10 Height; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg12227505 chr17:78194145 SLC26A11;SGSH 0.44 7.28 0.37 2.46e-12 Liver disease severity in Alagille syndrome; CRC cis rs896854 0.653 rs13266313 chr8:95975302 C/T cg09323728 chr8:95962352 TP53INP1 -0.45 -7.47 -0.38 7.48e-13 Type 2 diabetes; CRC cis rs3026101 0.671 rs2309372 chr17:5298396 G/A cg25236894 chr17:5323110 RPAIN;NUP88 0.42 6.84 0.35 3.98e-11 Body mass index; CRC cis rs6952808 0.825 rs34922657 chr7:1938655 C/T cg04267008 chr7:1944627 MAD1L1 -0.83 -12.66 -0.57 3.37e-30 Bipolar disorder and schizophrenia; CRC cis rs8062405 0.755 rs55792032 chr16:28599411 A/G cg16576597 chr16:28551801 NUPR1 0.55 8.11 0.41 1.05e-14 Cognitive ability (multi-trait analysis);Cognitive ability; CRC cis rs2075371 0.829 rs35897242 chr7:134004041 G/A cg11752832 chr7:134001865 SLC35B4 0.44 6.66 0.34 1.14e-10 Mean platelet volume; CRC cis rs11249608 0.548 rs6601007 chr5:178455796 G/C cg01312482 chr5:178451176 ZNF879 -0.35 -5.91 -0.31 8.6e-9 Pubertal anthropometrics; CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg11234017 chr17:42767172 CCDC43 -0.54 -6.63 -0.34 1.37e-10 Diisocyanate-induced asthma; CRC cis rs6424115 0.594 rs10799802 chr1:24009544 C/T cg10978503 chr1:24200527 CNR2 0.37 5.87 0.31 1.09e-8 Immature fraction of reticulocytes; CRC cis rs12802200 0.535 rs35391985 chr11:570280 T/C cg16486109 chr11:613632 IRF7 0.59 10.43 0.5 3.53e-22 Systemic lupus erythematosus; CRC cis rs231513 0.954 rs231498 chr17:41975251 C/G cg26893861 chr17:41843967 DUSP3 -0.6 -6.19 -0.32 1.76e-9 Cognitive function; CRC cis rs7020830 0.898 rs12000309 chr9:37230844 G/A cg14294708 chr9:37120828 ZCCHC7 1.19 27.04 0.83 1.29e-85 Schizophrenia; CRC cis rs7959452 0.530 rs12811632 chr12:69755003 G/A cg14784868 chr12:69753453 YEATS4 0.8 13.41 0.59 5.12e-33 Blood protein levels; CRC cis rs262150 0.819 rs6956589 chr7:158769301 C/T cg07130601 chr7:158766826 NA 0.41 5.84 0.31 1.27e-8 Facial morphology (factor 20); CRC cis rs6964587 0.933 rs10271174 chr7:91785970 A/G cg17063962 chr7:91808500 NA 0.83 14.94 0.64 6.89e-39 Breast cancer; CRC cis rs4563143 0.577 rs73025093 chr19:29254618 T/G cg14983838 chr19:29218262 NA 0.49 7.07 0.36 9.63e-12 Methadone dose in opioid dependence; CRC trans rs1814175 0.817 rs12290508 chr11:49621037 C/T cg11707556 chr5:10655725 ANKRD33B -0.43 -8.1 -0.41 1.08e-14 Height; CRC cis rs13315871 0.929 rs7643185 chr3:58311158 A/C cg20936604 chr3:58311152 NA 0.68 6.95 0.36 1.95e-11 Cholesterol, total; CRC cis rs7666738 0.830 rs34164616 chr4:99015251 G/A cg05340658 chr4:99064831 C4orf37 0.62 9.64 0.47 1.5700000000000001e-19 Colonoscopy-negative controls vs population controls; CRC cis rs10504229 0.639 rs2291764 chr8:58142943 A/C cg05313129 chr8:58192883 C8orf71 -0.5 -5.89 -0.31 9.4e-9 Developmental language disorder (linguistic errors); CRC cis rs7927771 0.965 rs11039416 chr11:47846711 G/A cg18512352 chr11:47633146 NA -0.48 -9.4 -0.46 9.71e-19 Subjective well-being; CRC cis rs780096 0.526 rs13391837 chr2:27649375 A/G cg02592271 chr2:27665507 KRTCAP3 -0.27 -6.04 -0.32 4.23e-9 Total body bone mineral density; CRC cis rs34172651 0.917 rs1465422 chr16:24772486 C/T cg06028605 chr16:24865363 SLC5A11 0.4 7.69 0.39 1.71e-13 Intelligence (multi-trait analysis); CRC cis rs1873147 0.569 rs11636033 chr15:63311091 G/T cg12160578 chr15:63334699 TPM1 -0.59 -7.44 -0.38 8.86e-13 Orofacial clefts; CRC cis rs72781680 0.898 rs12623316 chr2:24087857 A/G cg08917208 chr2:24149416 ATAD2B 0.92 9.37 0.46 1.23e-18 Lymphocyte counts; CRC cis rs79057730 0.599 rs6944167 chr7:826274 G/C cg05729249 chr7:766119 PRKAR1B;HEATR2 0.57 6.47 0.34 3.61e-10 Initial pursuit acceleration; CRC cis rs1129187 0.755 rs3293 chr6:42938377 G/T cg00597713 chr6:42947103 PEX6 -0.42 -5.98 -0.31 5.7e-9 Alzheimer's disease in APOE e4+ carriers; CRC cis rs798554 0.836 rs798500 chr7:2790685 C/T cg04166393 chr7:2884313 GNA12 -0.46 -6.18 -0.32 1.94e-9 Height; CRC cis rs13191362 0.507 rs2803083 chr6:163111199 A/C cg06582575 chr6:163149167 PACRG;PARK2 0.54 8.25 0.41 3.96e-15 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs7264396 0.887 rs2281849 chr20:34060286 T/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.38 -6.18 -0.32 1.88e-9 Total cholesterol levels; CRC cis rs977987 0.902 rs4888430 chr16:75494424 T/C cg03315344 chr16:75512273 CHST6 0.58 9.83 0.48 3.66e-20 Dupuytren's disease; CRC cis rs4727027 0.933 rs4727028 chr7:148874666 A/G cg12479418 chr7:148823350 ZNF425;ZNF398 -0.44 -6.1 -0.32 2.92e-9 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC trans rs66759488 0.739 rs10851451 chr15:47608991 A/G cg06572093 chr14:69095231 NA -0.42 -7.02 -0.36 1.27e-11 Lung cancer; CRC cis rs7264396 0.635 rs6060673 chr20:34482396 C/T cg04508476 chr20:34239394 CPNE1;RBM12 0.6 10.22 0.49 1.72e-21 Total cholesterol levels; CRC cis rs4664293 0.585 rs1991372 chr2:160516067 G/C cg08347373 chr2:160653686 CD302 0.39 6.58 0.34 1.91e-10 Monocyte percentage of white cells; CRC cis rs7914558 0.966 rs10748837 chr10:104880236 T/C cg04362960 chr10:104952993 NT5C2 0.59 8.76 0.43 1.06e-16 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs10504229 0.593 rs7000752 chr8:58026980 C/G cg02725872 chr8:58115012 NA -0.37 -6.4 -0.33 5.49e-10 Developmental language disorder (linguistic errors); CRC cis rs780096 0.526 rs780117 chr2:27698343 C/G cg22903471 chr2:27725779 GCKR -0.37 -6.06 -0.32 3.65e-9 Total body bone mineral density; CRC cis rs1448094 0.511 rs2405623 chr12:86153466 G/A cg25456477 chr12:86230367 RASSF9 -0.34 -5.87 -0.31 1.09e-8 Major depressive disorder; CRC cis rs56114371 0.530 rs169262 chr6:27770890 C/T cg03623178 chr6:28175578 NA 0.56 6.6 0.34 1.63e-10 Breast cancer; CRC cis rs10979 0.557 rs9390120 chr6:143909411 A/G cg25407410 chr6:143891975 LOC285740 -0.66 -8.82 -0.44 6.63e-17 Hypospadias; CRC cis rs4853012 0.941 rs4852329 chr2:74354544 A/G cg19729930 chr2:74357872 NA 0.79 11.75 0.54 7.54e-27 Gestational age at birth (maternal effect); CRC cis rs10256972 0.591 rs10229680 chr7:1158565 C/T cg16145915 chr7:1198662 ZFAND2A -0.42 -8.02 -0.4 1.92e-14 Longevity;Endometriosis; CRC trans rs11039798 0.582 rs60764175 chr11:48775856 T/G cg03929089 chr4:120376271 NA 0.67 7.05 0.36 1.06e-11 Axial length; CRC cis rs12135894 0.562 rs6688969 chr1:3743391 C/T cg13057898 chr1:3703894 LRRC47 0.41 6.01 0.31 4.98e-9 Mean corpuscular volume; CRC cis rs2228479 0.850 rs11649510 chr16:89851004 A/G cg06656553 chr16:89960601 TCF25 -0.7 -5.81 -0.3 1.51e-8 Skin colour saturation; CRC cis rs929354 0.806 rs28446734 chr7:156996775 T/C cg17757837 chr7:157058334 UBE3C 0.74 12.59 0.57 5.99e-30 Body mass index; CRC cis rs2073499 0.872 rs2239801 chr3:50402309 C/G cg09545109 chr3:50388910 TUSC4;CYB561D2 0.64 5.75 0.3 2.02e-8 Schizophrenia; CRC cis rs9303401 0.659 rs34818467 chr17:56643109 C/T cg02118635 chr17:56770003 RAD51C;TEX14 -0.67 -8.69 -0.43 1.69e-16 Cognitive test performance; CRC cis rs58688157 0.883 rs7936397 chr11:577534 G/A cg14433983 chr11:636460 DRD4 -0.44 -6.25 -0.33 1.26e-9 Systemic lupus erythematosus; CRC cis rs951366 0.873 rs823118 chr1:205723572 C/T cg26354017 chr1:205819088 PM20D1 0.47 7.07 0.36 9.54e-12 Menarche (age at onset); CRC cis rs2242116 0.761 rs6780601 chr3:46965856 A/G cg27129171 chr3:47204927 SETD2 0.63 9.02 0.45 1.63e-17 Birth weight; CRC cis rs2732480 0.577 rs2732466 chr12:48732459 A/G cg24011408 chr12:48396354 COL2A1 0.46 6.32 0.33 8.67e-10 Hemoglobin concentration;Red blood cell count;Hematocrit; CRC cis rs1218582 0.772 rs4845690 chr1:154886817 C/T cg16680214 chr1:154839983 KCNN3 0.46 9.17 0.45 5.42e-18 Prostate cancer; CRC cis rs853679 0.542 rs2295594 chr6:28053097 G/A cg02631126 chr6:28058918 ZSCAN12L1 0.29 6.09 0.32 3.1e-9 Depression; CRC cis rs1799949 1.000 rs11658754 chr17:41292739 G/A cg05368731 chr17:41323189 NBR1 0.69 10.5 0.5 1.94e-22 Menopause (age at onset); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg13051202 chr11:67887978 CHKA 0.4 6.07 0.32 3.48e-9 Intelligence (multi-trait analysis); CRC cis rs6502050 0.805 rs6502057 chr17:80082060 A/G cg02741985 chr17:80059408 CCDC57 -0.42 -6.84 -0.35 3.98e-11 Life satisfaction; CRC trans rs1814175 0.791 rs10839395 chr11:49846274 G/T cg11707556 chr5:10655725 ANKRD33B -0.41 -7.59 -0.39 3.4e-13 Height; CRC cis rs7542091 0.704 rs2142907 chr1:210039505 T/C cg05527609 chr1:210001259 C1orf107 -0.45 -5.85 -0.31 1.19e-8 Monobrow; CRC cis rs11758351 0.866 rs77205516 chr6:26205356 T/A cg10723962 chr6:26240782 HIST1H4F -0.38 -6.0 -0.31 5.06e-9 Gout;Renal underexcretion gout; CRC cis rs4563143 0.647 rs117946634 chr19:29256822 G/T cg12667521 chr19:29218732 NA 0.49 7.49 0.38 6.39e-13 Methadone dose in opioid dependence; CRC cis rs10905065 1.000 rs10737013 chr10:5746772 C/G cg11519256 chr10:5708881 ASB13 0.52 7.66 0.39 2.11e-13 Menopause (age at onset); CRC cis rs79387448 0.745 rs7583683 chr2:103113763 C/T cg00507830 chr2:103233733 NA -0.51 -5.66 -0.3 3.26e-8 Gut microbiota (bacterial taxa); CRC cis rs6951245 0.706 rs28685743 chr7:1197736 C/T cg21664854 chr7:1097933 C7orf50;GPR146 0.64 7.42 0.38 1e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs75920871 0.588 rs10892055 chr11:116868371 G/A cg01368799 chr11:117014884 PAFAH1B2 -0.43 -6.0 -0.31 5.3300000000000004e-09 Subjective well-being; CRC cis rs1124376 1.000 rs61138004 chr3:20145855 C/G cg05072819 chr3:20081367 KAT2B 0.51 5.85 0.31 1.19e-8 Bipolar disorder and schizophrenia; CRC cis rs4803468 1.000 rs10417311 chr19:41902038 G/A cg09537434 chr19:41945824 ATP5SL -0.97 -18.7 -0.72 1.09e-53 Height; CRC cis rs11098499 0.909 rs6842762 chr4:120398236 A/T cg24375607 chr4:120327624 NA 0.49 7.52 0.38 5.23e-13 Corneal astigmatism; CRC cis rs2153535 0.563 rs7739249 chr6:8534590 C/G cg21535247 chr6:8435926 SLC35B3 0.46 6.82 0.35 4.34e-11 Motion sickness; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg13896783 chr2:159313876 CCDC148;PKP4 -0.42 -6.25 -0.33 1.3e-9 Myopia (pathological); CRC trans rs116095464 0.558 rs62347677 chr5:227453 A/G cg00938859 chr5:1591904 SDHAP3 0.73 7.96 0.4 2.72e-14 Breast cancer; CRC cis rs62408225 0.722 rs10944481 chr6:90917314 A/G cg06866423 chr6:90926672 BACH2 -0.66 -12.37 -0.56 4.01e-29 Eosinophil counts;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC cis rs597539 0.652 rs636049 chr11:68667198 A/C cg04772025 chr11:68637568 NA 0.46 7.07 0.36 9.09e-12 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs7666738 0.830 rs6833312 chr4:98951356 A/T cg17366294 chr4:99064904 C4orf37 0.43 7.34 0.38 1.69e-12 Colonoscopy-negative controls vs population controls; CRC cis rs6840360 0.571 rs4696275 chr4:152530981 C/T cg09659197 chr4:152720779 NA 0.32 5.75 0.3 1.99e-8 Intelligence (multi-trait analysis); CRC cis rs7811142 0.562 rs7786844 chr7:99934008 T/G cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.7 9.78 0.47 5.39e-20 Platelet count; CRC cis rs17376456 0.877 rs10060160 chr5:93387879 G/A cg09848695 chr5:92956644 FAM172A;MIR2277 0.64 5.88 0.31 1.03e-8 Diabetic retinopathy; CRC cis rs12822507 0.783 rs10772586 chr12:12772866 C/A cg11838227 chr12:12764436 CREBL2 0.41 5.62 0.3 4.09e-8 Systemic lupus erythematosus; CRC cis rs7927592 0.913 rs11228292 chr11:68379772 C/T cg01657329 chr11:68192670 LRP5 -0.47 -6.59 -0.34 1.71e-10 Total body bone mineral density; CRC cis rs4713118 0.662 rs9468276 chr6:28027688 A/C cg25164649 chr6:28176230 NA 0.65 8.58 0.43 3.87e-16 Parkinson's disease; CRC cis rs873946 0.590 rs12783478 chr10:134550700 A/G cg06453172 chr10:134556979 INPP5A -0.64 -8.7 -0.43 1.62e-16 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CRC trans rs10504229 1.000 rs73609747 chr8:58189104 G/C cg04077850 chr5:125800366 GRAMD3 0.37 6.27 0.33 1.15e-9 Developmental language disorder (linguistic errors); CRC cis rs3736485 0.966 rs12443007 chr15:51892192 G/A cg08986416 chr15:51914746 DMXL2 -0.45 -6.4 -0.33 5.32e-10 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs10256972 0.630 rs13235747 chr7:1129123 T/C cg18765753 chr7:1198926 ZFAND2A -0.37 -6.32 -0.33 8.39e-10 Longevity;Endometriosis; CRC cis rs9462846 0.959 rs9462845 chr6:42860958 A/G cg10862848 chr6:42927986 GNMT -0.3 -5.64 -0.3 3.75e-8 Blood protein levels; CRC cis rs1008375 1.000 rs9991307 chr4:17662408 A/G cg04450456 chr4:17643702 FAM184B 0.43 6.86 0.35 3.36e-11 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs7762018 0.607 rs75999653 chr6:170066927 A/G cg19338460 chr6:170058176 WDR27 -1.24 -11.41 -0.53 1.23e-25 Thiazide-induced adverse metabolic effects in hypertensive patients; CRC cis rs13118159 0.801 rs1128427 chr4:1330759 T/C cg16405210 chr4:1374714 KIAA1530 -0.43 -5.83 -0.31 1.33e-8 Longevity; CRC cis rs10504073 0.584 rs1511365 chr8:49975321 A/T cg00325661 chr8:49890786 NA 0.58 10.72 0.51 3.27e-23 Blood metabolite ratios; CRC trans rs12517041 1.000 rs71611219 chr5:23280981 T/C ch.8.1293020R chr8:59333349 UBXN2B -0.54 -5.99 -0.31 5.61e-9 Calcium levels; CRC cis rs3213545 0.659 rs2259690 chr12:121457914 T/G cg25281562 chr12:121454272 C12orf43 0.39 5.69 0.3 2.83e-8 Subjective well-being;Cardiovascular disease risk factors; CRC cis rs17345786 1.000 rs17345528 chr3:101294830 A/C cg03837452 chr3:101395095 ZBTB11;LOC100009676 -0.54 -6.52 -0.34 2.6e-10 Colonoscopy-negative controls vs population controls; CRC cis rs6088580 0.634 rs6119497 chr20:33012529 T/A cg24642439 chr20:33292090 TP53INP2 0.37 6.3 0.33 9.54e-10 Glomerular filtration rate (creatinine); CRC trans rs4276421 0.806 rs6892290 chr5:45427137 A/G cg04793272 chr11:119020941 ABCG4 -0.38 -6.21 -0.32 1.61e-9 P wave duration; CRC cis rs7772486 0.790 rs2814880 chr6:146208937 T/G cg23711669 chr6:146136114 FBXO30 0.71 12.52 0.57 1.15e-29 Lobe attachment (rater-scored or self-reported); CRC cis rs9322193 0.962 rs3805752 chr6:150116626 C/T cg13206674 chr6:150067644 NUP43 0.67 9.32 0.46 1.7e-18 Lung cancer; CRC cis rs2257205 0.667 rs79155614 chr17:56722496 G/A cg25885038 chr17:56607967 SEPT4 -0.53 -5.77 -0.3 1.85e-8 Pancreatic cancer; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg19858671 chr8:130951373 FAM49B 0.41 6.37 0.33 6.22e-10 Liver disease severity in Alagille syndrome; CRC cis rs28386778 0.863 rs2597633 chr17:61872871 T/C cg23090583 chr17:61904693 PSMC5;FTSJ3 1.05 20.56 0.75 5.27e-61 Prudent dietary pattern; CRC cis rs6502050 0.761 rs13949 chr17:80059596 T/C cg25804541 chr17:80189381 SLC16A3 0.32 5.91 0.31 8.61e-9 Life satisfaction; CRC cis rs10779751 0.770 rs7553827 chr1:11222393 C/T cg08854313 chr1:11322531 MTOR 0.59 7.7 0.39 1.58e-13 Body mass index; CRC cis rs6951245 0.706 rs28483034 chr7:1170171 C/A cg22907277 chr7:1156413 C7orf50 0.78 8.94 0.44 2.87e-17 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg11817309 chr1:249152443 ZNF692 0.46 6.86 0.35 3.43e-11 Anxiety disorder; CRC cis rs6570726 0.791 rs6900040 chr6:145893134 C/T cg13319975 chr6:146136371 FBXO30 -0.42 -6.22 -0.32 1.53e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs801193 0.935 rs2659899 chr7:66186721 A/G cg05627663 chr7:65219948 SNORA22;CCT6P1 0.41 6.03 0.32 4.45e-9 Aortic root size; CRC cis rs4319547 0.695 rs4758666 chr12:122902840 C/T cg05707623 chr12:122985044 ZCCHC8 -0.61 -7.66 -0.39 2.05e-13 Body mass index; CRC cis rs10504229 0.775 rs17805146 chr8:58161484 G/A cg22535103 chr8:58192502 C8orf71 -0.71 -8.45 -0.42 9.58e-16 Developmental language disorder (linguistic errors); CRC cis rs897984 0.609 rs57576577 chr16:31036367 G/A cg00531865 chr16:30841666 NA -0.45 -6.36 -0.33 6.79e-10 Dementia with Lewy bodies; CRC trans rs2760061 0.626 rs2313118 chr1:228118084 T/C cg16006296 chr10:38738647 LOC399744 0.4 6.01 0.31 4.8e-9 Diastolic blood pressure; CRC cis rs7618501 1.000 rs6785549 chr3:49736565 G/A cg24308560 chr3:49941425 MST1R 0.45 7.07 0.36 9.52e-12 Intelligence (multi-trait analysis); CRC cis rs9522267 0.535 rs4773393 chr13:112229755 A/G cg26182253 chr13:112236782 NA 0.32 6.34 0.33 7.71e-10 Hepatitis; CRC cis rs6761276 0.899 rs13398125 chr2:113834835 G/A cg24553058 chr2:113831203 IL1F10 0.4 6.44 0.33 4.26e-10 Protein quantitative trait loci; CRC cis rs1552244 0.554 rs3732964 chr3:10048839 C/G cg00166722 chr3:10149974 C3orf24 0.43 6.37 0.33 6.36e-10 Alzheimer's disease; CRC cis rs8031584 0.541 rs2955797 chr15:31210981 A/G cg19680485 chr15:31195859 MTMR15 0.46 6.47 0.34 3.53e-10 Huntington's disease progression; CRC trans rs1814175 0.585 rs4881661 chr11:50000117 A/G cg11707556 chr5:10655725 ANKRD33B -0.52 -10.25 -0.49 1.36e-21 Height; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg15066777 chr18:66382427 CCDC102B;TMX3 0.44 6.14 0.32 2.33e-9 Anxiety disorder; CRC trans rs2727020 0.521 rs11040377 chr11:49474346 T/C cg15704280 chr7:45808275 SEPT13 -0.7 -11.02 -0.52 2.99e-24 Coronary artery disease; CRC cis rs17270561 0.779 rs1165200 chr6:25875212 C/T cg16482183 chr6:26056742 HIST1H1C -0.66 -8.04 -0.41 1.69e-14 Iron status biomarkers; CRC cis rs9916302 0.904 rs588193 chr17:37440439 A/C cg07936489 chr17:37558343 FBXL20 0.83 12.78 0.58 1.24e-30 Glomerular filtration rate (creatinine); CRC cis rs253959 0.672 rs1133186 chr5:115420415 A/C cg23108291 chr5:115420582 COMMD10 0.45 6.3 0.33 9.67e-10 Bipolar disorder and schizophrenia; CRC cis rs2228479 0.764 rs7184960 chr16:89961661 C/T cg06558623 chr16:89946397 TCF25 0.8 8.99 0.44 1.99e-17 Skin colour saturation; CRC trans rs7618501 0.521 rs11130222 chr3:49901060 A/T cg21659725 chr3:3221576 CRBN 0.5 7.11 0.36 7.29e-12 Intelligence (multi-trait analysis); CRC cis rs7552404 0.824 rs1251079 chr1:76189445 C/T cg22875332 chr1:76189707 ACADM 0.78 13.45 0.6 3.76e-33 Blood metabolite levels;Acylcarnitine levels; CRC cis rs4728302 0.838 rs13231095 chr7:133604436 A/G cg10665199 chr7:133106180 EXOC4 0.38 5.67 0.3 3.13e-8 Intelligence;Intelligence (multi-trait analysis); CRC cis rs2294693 0.786 rs10456497 chr6:40989057 T/C cg14769373 chr6:40998127 UNC5CL -0.5 -6.06 -0.32 3.78e-9 Gastric cancer;Non-cardia gastric cancer; CRC trans rs875971 0.660 rs2191268 chr7:66110224 C/T cg11342046 chr2:242641489 ING5 -0.44 -7.04 -0.36 1.14e-11 Aortic root size; CRC cis rs514406 0.505 rs269289 chr1:53167151 A/C cg08859206 chr1:53392774 SCP2 -0.43 -6.63 -0.34 1.35e-10 Monocyte count; CRC trans rs2303319 0.504 rs62188988 chr2:162531068 T/C cg12500891 chr11:57225987 NA -0.67 -6.27 -0.33 1.14e-9 Cognitive function; CRC cis rs245880 0.740 rs245898 chr7:29194143 G/A cg17163760 chr7:29186267 CPVL -0.39 -6.88 -0.35 3.05e-11 Warfarin maintenance dose; CRC cis rs3812762 0.826 rs2292045 chr11:8806709 G/T cg00186954 chr11:8933980 ST5;C11orf17 -0.43 -6.85 -0.35 3.66e-11 Hypospadias; CRC cis rs61008539 0.893 rs7783487 chr7:860160 A/C cg07138768 chr7:917805 C7orf20 0.3 5.81 0.31 1.46e-8 Perceived unattractiveness to mosquitoes; CRC cis rs4862750 0.914 rs1346126 chr4:187876404 T/C cg03647317 chr4:187891568 NA -0.54 -10.05 -0.48 6.85e-21 Lobe attachment (rater-scored or self-reported); CRC cis rs877282 0.945 rs12782447 chr10:771870 C/T cg06581033 chr10:766294 NA -0.54 -6.32 -0.33 8.41e-10 Uric acid levels; CRC cis rs10504229 0.683 rs34804288 chr8:58117570 C/A cg22535103 chr8:58192502 C8orf71 -0.7 -9.34 -0.46 1.47e-18 Developmental language disorder (linguistic errors); CRC cis rs17685 0.753 rs11972240 chr7:75694079 A/C cg16489192 chr7:75678113 MDH2;STYXL1 -0.36 -5.6 -0.3 4.41e-8 Coffee consumption;Coffee consumption (cups per day); CRC cis rs6570726 1.000 rs1935617 chr6:145943326 C/T cg23711669 chr6:146136114 FBXO30 0.66 10.87 0.51 9.76e-24 Lobe attachment (rater-scored or self-reported); CRC cis rs12410462 1.000 rs75637482 chr1:227622944 A/T cg04117972 chr1:227635322 NA 0.69 7.82 0.4 7.23e-14 Major depressive disorder; CRC cis rs801193 0.591 rs4506088 chr7:66135457 G/A cg12463550 chr7:65579703 CRCP -0.46 -6.18 -0.32 1.91e-9 Aortic root size; CRC cis rs34779708 0.931 rs72789687 chr10:35372489 G/A cg03585969 chr10:35415529 CREM 0.67 8.87 0.44 4.78e-17 Inflammatory bowel disease;Crohn's disease; CRC cis rs3733585 0.673 rs4495037 chr4:9954050 C/G cg11266682 chr4:10021025 SLC2A9 -0.47 -9.62 -0.47 1.76e-19 Cleft plate (environmental tobacco smoke interaction); CRC cis rs3733585 0.673 rs4519796 chr4:9955936 A/G cg00071950 chr4:10020882 SLC2A9 -0.55 -9.8 -0.48 4.49e-20 Cleft plate (environmental tobacco smoke interaction); CRC cis rs1322512 0.760 rs2695252 chr6:152926834 C/T cg03415253 chr6:152958462 SYNE1 -0.41 -6.48 -0.34 3.42e-10 Tonometry; CRC cis rs916888 0.773 rs199448 chr17:44809001 A/G cg01570182 chr17:44337453 NA 1.25 14.71 0.63 5.39e-38 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs6835098 0.961 rs2877748 chr4:174102397 G/A cg08422745 chr4:174089978 GALNT7 -0.95 -15.0 -0.64 4.17e-39 Dementia and core Alzheimer's disease neuropathologic changes; CRC trans rs2727020 0.553 rs4980447 chr11:49591662 T/C cg15704280 chr7:45808275 SEPT13 -0.76 -10.11 -0.49 4.31e-21 Coronary artery disease; CRC cis rs7527798 0.592 rs11118278 chr1:207831357 C/G cg21110645 chr1:207815933 NA -0.37 -5.85 -0.31 1.19e-8 Erythrocyte sedimentation rate; CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg03884976 chr16:577621 SOLH;C16orf10 0.39 6.1 0.32 2.98e-9 Obesity-related traits; CRC cis rs4665809 0.590 rs4665321 chr2:26433801 A/C cg26119090 chr2:26468346 HADHA;HADHB -1.06 -15.14 -0.64 1.2e-39 Gut microbiome composition (summer); CRC cis rs8105895 0.935 rs10405673 chr19:22244890 A/G cg02657401 chr19:22469223 NA -0.34 -5.65 -0.3 3.56e-8 Body mass index (change over time); CRC cis rs2688608 0.587 rs2894040 chr10:75478159 A/C cg16540259 chr10:75572220 NDST2 0.38 5.98 0.31 5.91e-9 Inflammatory bowel disease; CRC cis rs9478638 0.507 rs335368 chr6:155640881 C/T cg07943832 chr6:155568918 TIAM2 -0.46 -6.22 -0.32 1.48e-9 Electroencephalogram traits; CRC cis rs13191362 1.000 rs34443622 chr6:163208214 T/C cg21926612 chr6:163149169 PACRG;PARK2 0.95 12.33 0.56 5.74e-29 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs2204008 0.905 rs7294297 chr12:38442573 T/C cg26384229 chr12:38710491 ALG10B 0.64 8.86 0.44 5.13e-17 Bladder cancer; CRC cis rs6951245 0.938 rs113642700 chr7:1105654 C/T cg20603222 chr7:1096387 C7orf50;GPR146 -0.73 -8.71 -0.43 1.52e-16 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs7666738 0.830 rs28416660 chr4:98899525 C/G cg17366294 chr4:99064904 C4orf37 0.42 6.96 0.36 1.86e-11 Colonoscopy-negative controls vs population controls; CRC cis rs9903692 0.908 rs8066391 chr17:46195296 C/G cg21215337 chr17:46176117 CBX1 -0.43 -7.95 -0.4 3.09e-14 Pulse pressure; CRC cis rs10540 1.000 rs61876335 chr11:488878 T/C cg15790184 chr11:494944 RNH1 0.59 6.37 0.33 6.38e-10 Body mass index; CRC cis rs6426558 0.537 rs2102634 chr1:227324308 T/C cg10327440 chr1:227177885 CDC42BPA -0.47 -6.96 -0.36 1.88e-11 Neutrophil percentage of white cells; CRC cis rs2243480 1.000 rs1964692 chr7:65454183 G/A cg18252515 chr7:66147081 NA -1.06 -12.27 -0.56 9.34e-29 Diabetic kidney disease; CRC cis rs7659604 0.643 rs6838881 chr4:122663616 A/T cg06713675 chr4:122721982 EXOSC9 -0.4 -6.11 -0.32 2.74e-9 Type 2 diabetes; CRC cis rs7208859 0.673 rs73265624 chr17:29232066 G/A cg13385521 chr17:29058706 SUZ12P 0.69 7.93 0.4 3.48e-14 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg05299703 chr18:43678513 ATP5A1 0.45 6.06 0.32 3.71e-9 Thyroid stimulating hormone; CRC cis rs4319547 0.695 rs10744211 chr12:122931820 A/G cg05707623 chr12:122985044 ZCCHC8 -0.75 -9.47 -0.46 5.82e-19 Body mass index; CRC cis rs4304924 0.500 rs9601109 chr13:79220114 A/G cg01819759 chr13:79234251 RNF219 0.45 5.87 0.31 1.05e-8 Large artery stroke; CRC cis rs208520 0.690 rs207119 chr6:66786408 C/T cg07460842 chr6:66804631 NA -1.09 -15.38 -0.65 1.37e-40 Exhaled nitric oxide output; CRC cis rs6570726 0.935 rs436212 chr6:145849400 G/A cg23711669 chr6:146136114 FBXO30 0.68 12.3 0.56 7.07e-29 Lobe attachment (rater-scored or self-reported); CRC cis rs9894429 0.621 rs7502337 chr17:79588470 T/C cg18240062 chr17:79603768 NPLOC4 0.48 7.46 0.38 7.97e-13 Eye color traits; CRC trans rs12663356 0.528 rs9350359 chr6:21462624 C/T cg01490821 chr2:170684022 UBR3 0.41 6.01 0.31 4.96e-9 Crohn's disease; CRC trans rs561341 0.710 rs9900031 chr17:30199537 T/C cg20587970 chr11:113659929 NA 0.82 9.95 0.48 1.43e-20 Hip circumference adjusted for BMI; CRC cis rs10504229 0.639 rs17331850 chr8:58113538 G/T cg05313129 chr8:58192883 C8orf71 -0.43 -6.0 -0.31 5.07e-9 Developmental language disorder (linguistic errors); CRC trans rs7615952 0.546 rs2922197 chr3:125322032 G/A cg21747405 chr11:67723411 NA -0.5 -6.24 -0.33 1.34e-9 Blood pressure (smoking interaction); CRC cis rs7945705 0.818 rs2653613 chr11:8879105 C/T cg14711859 chr11:8959438 ASCL3 0.4 6.76 0.35 6.23e-11 Hemoglobin concentration; CRC cis rs7762018 1.000 rs1127489 chr6:170107702 C/T cg24289452 chr6:170231220 NA -0.58 -6.3 -0.33 9.43e-10 Thiazide-induced adverse metabolic effects in hypertensive patients; CRC cis rs3757247 0.631 rs2501716 chr6:90892399 C/G cg06866423 chr6:90926672 BACH2 -0.42 -6.69 -0.35 9.81e-11 Vitiligo;Type 1 diabetes; CRC cis rs9648716 0.938 rs11981790 chr7:140588384 A/C cg10747023 chr7:140774559 NA 0.45 5.96 0.31 6.33e-9 Type 2 diabetes; CRC cis rs5769765 0.955 rs9616204 chr22:50303530 T/C cg02269571 chr22:50332266 NA -0.56 -7.53 -0.38 4.95e-13 Schizophrenia; CRC cis rs7769051 0.711 rs9493437 chr6:133088405 A/T cg22852734 chr6:133119734 C6orf192 0.88 10.36 0.5 6.12e-22 Type 2 diabetes nephropathy; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg18149689 chr3:193721164 NA 0.39 6.39 0.33 5.6e-10 Liver disease severity in Alagille syndrome; CRC cis rs1401999 0.836 rs34571027 chr3:183726644 T/C cg20387954 chr3:183756860 HTR3D 0.45 7.86 0.4 5.7e-14 Anterior chamber depth; CRC cis rs427941 0.703 rs1734879 chr7:101740610 C/A cg06246474 chr7:101738831 CUX1 0.46 7.24 0.37 3.2e-12 Plasma omega-3 polyunsaturated fatty acid level (eicosapentaenoic acid); CRC cis rs2281845 0.826 rs4915214 chr1:201076290 T/A cg24849736 chr1:201084428 NA 0.59 10.5 0.5 1.91e-22 Permanent tooth development; CRC cis rs4665809 0.590 rs34728554 chr2:26481959 C/G cg04944784 chr2:26401820 FAM59B 0.85 11.05 0.52 2.29e-24 Gut microbiome composition (summer); CRC cis rs6088590 1.000 rs2378256 chr20:33292127 G/C cg08999081 chr20:33150536 PIGU 0.53 8.96 0.44 2.49e-17 Coronary artery disease; CRC cis rs4819052 0.851 rs1056101 chr21:46678702 C/G cg02159808 chr21:46707872 POFUT2;LOC642852 0.52 6.88 0.35 2.99e-11 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs9549328 0.700 rs34890317 chr13:113617245 G/C cg20742385 chr13:113633654 MCF2L 0.56 9.52 0.46 3.92e-19 Systolic blood pressure; CRC cis rs10504229 0.683 rs7459925 chr8:58111771 G/A cg04204079 chr8:58130323 NA -0.46 -5.84 -0.31 1.22e-8 Developmental language disorder (linguistic errors); CRC cis rs7312933 1.000 rs11181308 chr12:42445259 A/G cg01256987 chr12:42539512 GXYLT1 -0.44 -6.62 -0.34 1.45e-10 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CRC cis rs79349575 0.783 rs61576918 chr17:46985593 A/C cg00947319 chr17:47005597 UBE2Z -0.34 -5.91 -0.31 8.38e-9 Type 2 diabetes; CRC trans rs66887589 0.592 rs28580295 chr4:120278873 C/T cg25214090 chr10:38739885 LOC399744 0.4 6.06 0.32 3.72e-9 Diastolic blood pressure; CRC cis rs2274273 0.773 rs8006525 chr14:55813394 T/G cg23234261 chr14:55582407 NA -0.29 -5.72 -0.3 2.41e-8 Protein biomarker; CRC cis rs826838 0.904 rs7973992 chr12:39168233 T/C cg26384229 chr12:38710491 ALG10B 0.7 9.67 0.47 1.21e-19 Heart rate; CRC cis rs8031584 0.652 rs2691683 chr15:31135060 A/G cg08109568 chr15:31115862 NA 0.68 10.6 0.5 8.86e-23 Huntington's disease progression; CRC cis rs10504229 0.683 rs11774645 chr8:58132921 G/C cg08219700 chr8:58056026 NA 0.57 6.86 0.35 3.5e-11 Developmental language disorder (linguistic errors); CRC cis rs9925964 0.933 rs2303223 chr16:31075175 G/A cg02466173 chr16:30829666 NA 0.43 5.8 0.3 1.53e-8 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC trans rs2727020 0.675 rs1684258 chr11:49340020 G/A cg15704280 chr7:45808275 SEPT13 0.69 8.63 0.43 2.69e-16 Coronary artery disease; CRC cis rs9322193 0.923 rs9766886 chr6:149958184 T/C cg05861140 chr6:150128134 PCMT1 -0.36 -5.92 -0.31 8.26e-9 Lung cancer; CRC cis rs9287719 0.967 rs6733416 chr2:10738684 C/T cg00105475 chr2:10696890 NA 0.45 7.3 0.37 2.19e-12 Prostate cancer; CRC cis rs1062753 0.922 rs9611712 chr22:42410993 T/C cg22189786 chr22:42395067 WBP2NL 0.43 6.25 0.33 1.27e-9 Response to serotonin reuptake inhibitors in major depressive disorder (plasma drug and metabolite levels); CRC cis rs13315871 0.929 rs35557787 chr3:58234536 T/C cg20936604 chr3:58311152 NA -0.67 -6.73 -0.35 7.62e-11 Cholesterol, total; CRC cis rs62408225 0.569 rs2174281 chr6:90987872 T/C cg06866423 chr6:90926672 BACH2 0.37 6.32 0.33 8.36e-10 Eosinophil counts;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC cis rs8099014 0.861 rs6566969 chr18:56118999 A/G cg12907477 chr18:56117327 MIR122 0.43 5.64 0.3 3.72e-8 Platelet count; CRC cis rs1448094 0.511 rs7967183 chr12:86216845 T/G cg18827107 chr12:86230957 RASSF9 -0.44 -7.24 -0.37 3.13e-12 Major depressive disorder; CRC cis rs17270561 0.666 rs1141034 chr6:25780332 C/T cg16482183 chr6:26056742 HIST1H1C 0.75 9.53 0.47 3.48e-19 Iron status biomarkers; CRC cis rs9291683 0.546 rs6820188 chr4:10051655 C/T cg00071950 chr4:10020882 SLC2A9 0.61 11.14 0.52 1.18e-24 Bone mineral density; CRC cis rs6460942 0.915 rs7802454 chr7:12454508 A/G cg20607287 chr7:12443886 VWDE -0.66 -6.93 -0.36 2.17e-11 Coronary artery disease; CRC cis rs501120 0.564 rs1704214 chr10:44682729 A/G cg09554077 chr10:44749378 NA 0.55 7.67 0.39 1.95e-13 Coronary artery disease;Coronary heart disease; CRC cis rs7635838 0.617 rs347590 chr3:11289561 G/A cg00170343 chr3:11313890 ATG7 0.58 9.01 0.44 1.72e-17 HDL cholesterol; CRC cis rs4862750 0.874 rs6822062 chr4:187895553 T/C cg22105103 chr4:187893119 NA 0.63 11.51 0.54 5.41e-26 Lobe attachment (rater-scored or self-reported); CRC cis rs6748734 1.000 rs11893118 chr2:241828308 C/G cg04034577 chr2:241836375 C2orf54 -0.44 -9.54 -0.47 3.3e-19 Urinary metabolites; CRC cis rs9372498 0.536 rs72952733 chr6:118834452 A/G cg22561889 chr6:118971681 C6orf204 0.47 5.93 0.31 7.61e-9 Diastolic blood pressure; CRC cis rs45509595 0.841 rs200485 chr6:27775697 G/C cg06470822 chr6:28175283 NA 0.66 5.61 0.3 4.35e-8 Breast cancer; CRC cis rs6570726 0.935 rs409121 chr6:145839793 G/A cg23711669 chr6:146136114 FBXO30 0.68 12.16 0.56 2.33e-28 Lobe attachment (rater-scored or self-reported); CRC cis rs875971 0.862 rs709596 chr7:65825913 A/G cg12463550 chr7:65579703 CRCP 0.5 7.19 0.37 4.4e-12 Aortic root size; CRC cis rs7259376 0.837 rs16999542 chr19:22573092 A/C cg02657401 chr19:22469223 NA -0.31 -6.81 -0.35 4.64e-11 Menopause (age at onset); CRC cis rs7772486 0.686 rs7739735 chr6:146123536 G/A cg23711669 chr6:146136114 FBXO30 0.69 11.62 0.54 2.27e-26 Lobe attachment (rater-scored or self-reported); CRC cis rs1046896 0.553 rs72634343 chr17:80827392 T/C cg19046167 chr17:80928561 B3GNTL1 0.51 7.12 0.37 6.91e-12 Glycated hemoglobin levels; CRC cis rs449789 0.711 rs7765794 chr6:159704925 T/C cg14500486 chr6:159655392 FNDC1 -0.48 -7.4 -0.38 1.13e-12 Pulse pressure; CRC cis rs1451375 0.617 rs12671474 chr7:50591395 C/A cg14593290 chr7:50529359 DDC 0.64 8.51 0.42 6.25e-16 Malaria; CRC trans rs9388451 0.874 rs7739566 chr6:126094757 A/T cg05039488 chr6:79577232 IRAK1BP1 -0.55 -8.37 -0.42 1.69e-15 Brugada syndrome; CRC cis rs3858526 0.584 rs10769274 chr11:5866925 T/C cg25319279 chr11:5960081 NA -0.37 -5.77 -0.3 1.83e-8 DNA methylation (variation); CRC trans rs4650994 0.525 rs4650991 chr1:178511165 C/T cg05059571 chr16:84539110 KIAA1609 -0.64 -8.88 -0.44 4.48e-17 HDL cholesterol levels;HDL cholesterol; CRC cis rs589448 0.902 rs315138 chr12:69764850 A/T cg20891283 chr12:69753455 YEATS4 0.98 21.22 0.76 1.46e-63 Cerebrospinal fluid biomarker levels; CRC cis rs394563 0.591 rs11964335 chr6:149658101 A/T cg07828024 chr6:149772892 ZC3H12D 0.47 8.76 0.43 1.05e-16 Dupuytren's disease; CRC cis rs28386778 0.830 rs2665841 chr17:61861219 A/T cg22520471 chr17:61851767 DDX42;CCDC47 0.75 11.69 0.54 1.26e-26 Prudent dietary pattern; CRC cis rs1784581 0.588 rs10945792 chr6:162423484 C/T cg17173639 chr6:162384350 PARK2 0.6 9.67 0.47 1.23e-19 Itch intensity from mosquito bite; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg19357178 chr21:45527350 PWP2 0.43 6.42 0.33 4.66e-10 Intelligence (multi-trait analysis); CRC cis rs4862750 0.914 rs6553028 chr4:187876046 T/C cg06074448 chr4:187884817 NA -0.59 -10.73 -0.51 3.05e-23 Lobe attachment (rater-scored or self-reported); CRC cis rs9303401 0.659 rs35828828 chr17:56718205 C/T cg02118635 chr17:56770003 RAD51C;TEX14 0.79 9.86 0.48 2.81e-20 Cognitive test performance; CRC cis rs2153535 0.580 rs4365970 chr6:8453813 C/T cg21535247 chr6:8435926 SLC35B3 -0.47 -6.97 -0.36 1.75e-11 Motion sickness; CRC cis rs812925 0.537 rs778146 chr2:61606475 A/G cg10580144 chr2:61372316 C2orf74 -0.33 -7.37 -0.38 1.38e-12 Immature fraction of reticulocytes; CRC cis rs2415984 0.579 rs61993338 chr14:46969142 T/C cg14871534 chr14:47121158 RPL10L -0.43 -6.25 -0.33 1.24e-9 Number of children ever born; CRC cis rs7666738 0.753 rs28463863 chr4:98844444 T/C cg17366294 chr4:99064904 C4orf37 0.42 6.82 0.35 4.38e-11 Colonoscopy-negative controls vs population controls; CRC trans rs2243480 0.614 rs34032527 chr7:65565141 C/G cg10756647 chr7:56101905 PSPH 0.69 7.49 0.38 6.21e-13 Diabetic kidney disease; CRC cis rs9916302 0.904 rs3744348 chr17:37417575 C/G cg03013999 chr17:37608204 MED1 0.49 7.54 0.38 4.62e-13 Glomerular filtration rate (creatinine); CRC cis rs7666738 0.830 rs921521 chr4:98838339 A/G cg17366294 chr4:99064904 C4orf37 0.44 7.06 0.36 9.79e-12 Colonoscopy-negative controls vs population controls; CRC cis rs2836950 0.565 rs2836930 chr21:40545656 A/G cg11890956 chr21:40555474 PSMG1 -0.69 -10.48 -0.5 2.33e-22 Menarche (age at onset); CRC cis rs9304742 0.854 rs11084211 chr19:53460861 C/T cg09915433 chr19:53449742 NA -0.59 -8.85 -0.44 5.69e-17 Psoriasis; CRC cis rs747650 0.859 rs4567413 chr11:47232184 A/G cg03339077 chr11:47165057 C11orf49 0.47 6.61 0.34 1.57e-10 Acne (severe); CRC cis rs1538970 0.924 rs3790582 chr1:45887288 T/C cg05343316 chr1:45956843 TESK2 0.76 10.28 0.49 1.08e-21 Platelet count; CRC cis rs4689388 0.890 rs11732208 chr4:6292716 G/C cg00701064 chr4:6280414 WFS1 0.73 12.78 0.58 1.17e-30 Type 2 diabetes and other traits;Type 2 diabetes; CRC cis rs2280018 0.526 rs1510148 chr16:15167379 T/A cg27102117 chr16:15229624 NA 0.49 8.22 0.41 4.68e-15 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid);Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CRC cis rs6952808 0.692 rs10950473 chr7:1999453 G/A cg04267008 chr7:1944627 MAD1L1 -0.8 -11.62 -0.54 2.27e-26 Bipolar disorder and schizophrenia; CRC cis rs10751667 0.666 rs7395182 chr11:927553 A/C cg23136738 chr11:925521 AP2A2 -0.41 -6.8 -0.35 4.92e-11 Alzheimer's disease (late onset); CRC cis rs17401966 1.000 rs4846208 chr1:10313839 T/C cg19773385 chr1:10388646 KIF1B -0.58 -8.04 -0.41 1.58e-14 Hepatocellular carcinoma; CRC cis rs8180040 0.545 rs9311403 chr3:47138878 T/C cg02527881 chr3:46936655 PTH1R -0.34 -5.95 -0.31 6.84e-9 Colorectal cancer; CRC cis rs447 0.806 rs4732545 chr7:83745971 C/T cg22846510 chr7:83753280 SEMA3A -0.41 -5.67 -0.3 3.21e-8 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs2845885 0.793 rs3751120 chr11:63884453 C/T cg24431193 chr11:63883947 FLRT1;MACROD1 0.74 8.94 0.44 2.83e-17 Body mass index; CRC cis rs4665809 0.590 rs4665315 chr2:26416036 T/G cg25036284 chr2:26402008 FAM59B -0.6 -7.65 -0.39 2.29e-13 Gut microbiome composition (summer); CRC cis rs10540 1.000 rs117339389 chr11:505025 T/A cg03576123 chr11:487126 PTDSS2 -1.01 -10.24 -0.49 1.49e-21 Body mass index; CRC cis rs2439831 0.867 rs935901 chr15:43651256 G/C cg02155558 chr15:43621948 ADAL;LCMT2 0.82 8.01 0.4 2.05e-14 Lung cancer in ever smokers; CRC cis rs2281845 0.965 rs7516023 chr1:201085521 C/T cg17810781 chr1:201082982 CACNA1S 0.49 8.22 0.41 4.71e-15 Permanent tooth development; CRC cis rs9915657 0.743 rs9894720 chr17:70097607 C/T cg09344028 chr17:70110421 NA 0.48 7.72 0.39 1.41e-13 Thyroid hormone levels; CRC cis rs1552244 1.000 rs6807846 chr3:10134491 G/T cg13047869 chr3:10149882 C3orf24 0.52 7.31 0.37 2.02e-12 Alzheimer's disease; CRC cis rs8017423 0.565 rs4904681 chr14:90835566 A/T cg14092571 chr14:90743983 NA 0.38 5.72 0.3 2.38e-8 Mortality in heart failure; CRC cis rs7202877 0.611 rs7187263 chr16:75308978 C/A cg03315344 chr16:75512273 CHST6 0.51 6.01 0.31 5.01e-9 Type 2 diabetes;Type 1 diabetes; CRC cis rs951366 0.764 rs823143 chr1:205743425 A/C cg07167872 chr1:205819463 PM20D1 0.78 12.17 0.56 2.2e-28 Menarche (age at onset); CRC trans rs7324845 0.688 rs1980830 chr13:46712587 C/T cg15277906 chr8:97170364 GDF6 -0.54 -6.15 -0.32 2.19e-9 Non-alcoholic fatty liver disease histology (other); CRC cis rs736408 0.509 rs2590838 chr3:52622086 G/A cg05573699 chr3:52720067 GNL3;PBRM1 -0.49 -7.55 -0.38 4.36e-13 Bipolar disorder; CRC cis rs7737355 0.812 rs11242083 chr5:130927526 A/T cg25547332 chr5:131281432 NA 0.37 5.73 0.3 2.28e-8 Life satisfaction; CRC cis rs4908768 0.501 rs12046643 chr1:8547866 A/C cg20416874 chr1:8611966 RERE -0.45 -6.42 -0.33 4.68e-10 Neuroticism (multi-trait analysis);Subjective well-being (multi-trait analysis); CRC cis rs28386778 0.897 rs2665832 chr17:61912261 C/T cg25654072 chr17:61904446 PSMC5;FTSJ3 0.71 11.18 0.52 8.51e-25 Prudent dietary pattern; CRC cis rs3091242 0.867 rs602052 chr1:25722206 T/C cg20684491 chr1:25596433 NA 0.41 7.15 0.37 5.82e-12 Erythrocyte sedimentation rate; CRC cis rs4690686 0.500 rs11725547 chr4:177268444 T/C cg17059388 chr4:177262070 NA 0.39 5.78 0.3 1.71e-8 Essential tremor; CRC cis rs11690462 0.926 rs11689086 chr2:26549127 C/T cg22920501 chr2:26401640 FAM59B 0.4 5.71 0.3 2.57e-8 Coronary artery disease; CRC cis rs853679 0.542 rs9393892 chr6:28081394 A/G cg21251018 chr6:28226885 NKAPL 0.48 6.31 0.33 9.16e-10 Depression; CRC cis rs1862618 0.853 rs832553 chr5:56114786 A/G cg24531977 chr5:56204891 C5orf35 -0.8 -10.81 -0.51 1.69e-23 Initial pursuit acceleration; CRC cis rs12477438 0.520 rs6717723 chr2:99756930 T/C cg14399236 chr2:99771627 LIPT1;TSGA10 0.83 14.8 0.63 2.35e-38 Chronic sinus infection; CRC cis rs12142240 0.698 rs72677592 chr1:46818288 A/G cg00530320 chr1:46809349 NSUN4 0.58 7.96 0.4 2.82e-14 Menopause (age at onset); CRC cis rs1506636 0.927 rs6959270 chr7:123310628 G/A cg03229431 chr7:123269106 ASB15 -0.75 -12.09 -0.55 4.23e-28 Plateletcrit;Platelet count; CRC cis rs6964587 0.633 rs13231620 chr7:91507859 G/A cg17063962 chr7:91808500 NA -0.69 -10.56 -0.5 1.23e-22 Breast cancer; CRC cis rs7781557 0.646 rs12113759 chr7:102440914 C/T cg18108683 chr7:102477205 FBXL13 -0.51 -6.61 -0.34 1.53e-10 Colorectal adenoma (advanced); CRC cis rs11112613 0.713 rs17041546 chr12:105950801 G/T cg03607813 chr12:105948248 NA -0.75 -10.76 -0.51 2.39e-23 Corrected insulin response;Corrected insulin response adjusted for insulin sensitivity index; CRC cis rs2303759 0.709 rs8102574 chr19:49828897 A/G cg22133161 chr19:49891603 CCDC155 0.52 6.65 0.34 1.22e-10 Multiple sclerosis; CRC cis rs7766336 0.533 rs11754600 chr6:105388718 C/T cg02098413 chr6:105308735 HACE1 0.31 5.61 0.3 4.24e-8 Menarche (age at onset); CRC cis rs1008375 1.000 rs114490726 chr4:17680898 T/C cg04450456 chr4:17643702 FAM184B 0.4 6.31 0.33 8.83e-10 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs6912958 0.781 rs2300906 chr6:88207155 G/A cg08069147 chr6:88032118 GJB7;C6orf162 -0.57 -8.36 -0.42 1.77e-15 Monocyte percentage of white cells; CRC cis rs8072100 0.935 rs78551919 chr17:45626002 A/C cg25173405 chr17:45401733 C17orf57 0.47 7.38 0.38 1.32e-12 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs7943191 0.810 rs7942991 chr11:62337203 A/G cg11742103 chr11:62369870 EML3;MTA2 -0.57 -9.48 -0.46 5.15e-19 Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction); CRC cis rs344364 0.602 rs8044343 chr16:1881145 G/C cg00046913 chr16:1877150 HAGH;FAHD1 -0.45 -5.61 -0.3 4.33e-8 Glomerular filtration rate in chronic kidney disease; CRC trans rs2228213 0.585 rs9296258 chr6:12084445 C/G cg07575407 chr15:66541975 MEGF11 0.38 6.09 0.32 3.15e-9 Body mass index; CRC cis rs10504229 0.953 rs114853497 chr8:58176176 A/T cg05313129 chr8:58192883 C8orf71 -0.47 -6.99 -0.36 1.49e-11 Developmental language disorder (linguistic errors); CRC cis rs853679 0.517 rs9380058 chr6:28127444 T/C cg18032046 chr6:28092343 ZSCAN16 -0.52 -5.93 -0.31 7.58e-9 Depression; CRC cis rs62064224 0.614 rs2286645 chr17:30696292 C/T cg25809561 chr17:30822961 MYO1D 0.51 9.05 0.45 1.27e-17 Schizophrenia; CRC cis rs7945705 0.818 rs2742552 chr11:8876852 C/T cg12365402 chr11:9010492 NRIP3 -0.51 -8.99 -0.44 2e-17 Hemoglobin concentration; CRC cis rs6860806 0.531 rs272888 chr5:131665423 T/C cg27615366 chr5:131592974 PDLIM4 0.32 5.7 0.3 2.69e-8 Breast cancer; CRC cis rs40363 0.645 rs1690447 chr16:3519211 T/C cg21433313 chr16:3507492 NAT15 0.61 8.68 0.43 1.9e-16 Tuberculosis; CRC cis rs703970 0.521 rs1574190 chr10:80992381 A/G cg20744163 chr10:80999841 ZMIZ1 0.33 5.63 0.3 3.79e-8 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs12701220 0.500 rs6463224 chr7:1140418 C/A cg26769984 chr7:1090371 C7orf50 0.5 7.1 0.36 7.82e-12 Bronchopulmonary dysplasia; CRC cis rs911119 0.913 rs1158167 chr20:23578189 G/A cg16589663 chr20:23618590 CST3 -0.43 -6.16 -0.32 2.07e-9 Chronic kidney disease; CRC cis rs651907 0.535 rs4342086 chr3:101503765 G/A cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.58 7.71 0.39 1.54e-13 Colorectal cancer; CRC cis rs9311474 0.629 rs4282054 chr3:52566065 T/C cg08365687 chr3:52569147 NT5DC2;LOC440957 0.35 5.8 0.3 1.55e-8 Electroencephalogram traits; CRC cis rs7666738 0.830 rs35644814 chr4:98886111 G/C cg17366294 chr4:99064904 C4orf37 0.42 6.83 0.35 4.15e-11 Colonoscopy-negative controls vs population controls; CRC cis rs55882075 0.634 rs12518476 chr5:179110850 A/G cg14593053 chr5:179126677 CANX 0.51 7.64 0.39 2.46e-13 Monocyte percentage of white cells; CRC cis rs6701037 1.000 rs7514749 chr1:175122123 A/G cg00321850 chr1:175162397 KIAA0040 -0.36 -5.89 -0.31 9.48e-9 Alcohol dependence; CRC cis rs2153535 0.580 rs6900007 chr6:8474035 C/T cg07606381 chr6:8435919 SLC35B3 0.68 10.9 0.51 8.26e-24 Motion sickness; CRC cis rs727505 0.954 rs58618031 chr7:124583896 T/C cg23710748 chr7:124431027 NA -0.68 -11.76 -0.54 6.97e-27 Lewy body disease; CRC cis rs13108904 0.934 rs13115173 chr4:1316824 T/C cg00684032 chr4:1343700 KIAA1530 0.49 7.32 0.37 1.94e-12 Obesity-related traits; CRC cis rs478304 0.593 rs4645933 chr11:65485120 C/T cg05805236 chr11:65401703 PCNXL3 -0.38 -5.98 -0.31 5.86e-9 Acne (severe); CRC cis rs7769051 1.000 rs7765224 chr6:133101624 T/C cg07930552 chr6:133119739 C6orf192 0.59 6.96 0.36 1.81e-11 Type 2 diabetes nephropathy; CRC cis rs7945705 0.905 rs7947631 chr11:8844909 A/G cg00186954 chr11:8933980 ST5;C11orf17 -0.39 -6.17 -0.32 1.98e-9 Hemoglobin concentration; CRC trans rs2303319 0.504 rs56009150 chr2:162598582 T/C cg03774468 chr3:140950104 ACPL2 -0.66 -6.1 -0.32 3.01e-9 Cognitive function; CRC cis rs4803468 1.000 rs284652 chr19:41928652 C/T cg09537434 chr19:41945824 ATP5SL -0.97 -18.39 -0.71 1.96e-52 Height; CRC cis rs12760731 0.582 rs4607830 chr1:178535152 A/G cg00404053 chr1:178313656 RASAL2 0.57 6.69 0.35 9.74e-11 Obesity-related traits; CRC cis rs2952156 0.959 rs2517956 chr17:37843859 G/A cg20243544 chr17:37824526 PNMT 0.56 8.61 0.43 2.97e-16 Asthma; CRC cis rs13256369 0.851 rs11249890 chr8:8565245 G/T cg18904891 chr8:8559673 CLDN23 0.55 7.3 0.37 2.12e-12 Obesity-related traits; CRC cis rs2249694 0.520 rs7077457 chr10:135324370 G/T cg20169779 chr10:135381914 SYCE1 -0.49 -6.92 -0.36 2.43e-11 Obesity-related traits; CRC cis rs2257205 0.667 rs8075108 chr17:56657248 G/A cg25885038 chr17:56607967 SEPT4 -0.56 -6.15 -0.32 2.19e-9 Pancreatic cancer; CRC cis rs2073300 0.609 rs3746737 chr20:23424638 C/T cg12062639 chr20:23401060 NAPB 0.81 7.38 0.38 1.27e-12 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs2749592 0.513 rs1208708 chr10:38085576 A/G cg25951256 chr10:38645740 HSD17B7P2 -0.4 -5.73 -0.3 2.31e-8 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs2694528 0.686 rs6885703 chr5:59862790 T/C cg11474532 chr5:59995715 DEPDC1B 0.66 5.63 0.3 3.96e-8 Parkinson's disease; CRC cis rs10191773 0.589 rs72831638 chr2:112949212 C/G cg23609528 chr2:113191194 RGPD5;RGPD8 0.66 5.67 0.3 3.18e-8 Yeast infection; CRC cis rs10504229 1.000 rs1961778 chr8:58168756 G/A cg02725872 chr8:58115012 NA -0.38 -6.7 -0.35 9.17e-11 Developmental language disorder (linguistic errors); CRC cis rs6952808 0.630 rs1860832 chr7:2161849 G/A cg04267008 chr7:1944627 MAD1L1 -0.63 -8.56 -0.43 4.48e-16 Bipolar disorder and schizophrenia; CRC cis rs7917772 0.508 rs2252147 chr10:104467774 G/A cg11453585 chr10:104263688 ACTR1A;SUFU 0.75 10.34 0.5 7.21e-22 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC cis rs720844 1.000 rs720844 chr2:149350128 G/A cg09247360 chr2:149335327 NA -0.63 -7.74 -0.39 1.21e-13 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs1728785 1.000 rs1645927 chr16:68589300 T/G cg02972257 chr16:68554789 NA -0.61 -7.61 -0.39 2.89e-13 Ulcerative colitis; CRC trans rs11098499 0.690 rs34818745 chr4:120257055 T/C cg25214090 chr10:38739885 LOC399744 0.58 8.47 0.42 8.12e-16 Corneal astigmatism; CRC cis rs1707322 0.927 rs6690386 chr1:46253011 C/T cg06784218 chr1:46089804 CCDC17 0.59 10.54 0.5 1.44e-22 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg05370860 chr19:10514434 MIR1181;CDC37 0.42 6.23 0.32 1.46e-9 Intelligence (multi-trait analysis); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg19537317 chr19:36337105 NPHS1 0.4 6.29 0.33 9.89e-10 Response to antipsychotic treatment; CRC cis rs9341808 0.718 rs10943699 chr6:80940541 G/A cg08355045 chr6:80787529 NA 0.42 6.7 0.35 8.85e-11 Sitting height ratio; CRC cis rs7786877 0.723 rs11764045 chr7:100212754 C/T cg00334542 chr7:100209784 MOSPD3 -0.7 -7.99 -0.4 2.24e-14 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs478304 0.627 rs11227254 chr11:65454000 A/G cg05805236 chr11:65401703 PCNXL3 -0.41 -6.54 -0.34 2.29e-10 Acne (severe); CRC cis rs300703 0.542 rs67993758 chr2:179594 C/T cg21211680 chr2:198530 NA -0.71 -9.44 -0.46 6.94e-19 Blood protein levels; CRC cis rs1656402 1.000 rs2077975 chr2:233425877 C/A cg03852847 chr2:233439513 NA 0.45 7.66 0.39 2.12e-13 Non-small cell lung cancer (survival); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg16261398 chr11:1410750 BRSK2 0.36 6.26 0.33 1.18e-9 Liver disease severity in Alagille syndrome; CRC cis rs72781680 0.821 rs56064672 chr2:24156769 G/T cg08917208 chr2:24149416 ATAD2B 0.56 6.77 0.35 6.02e-11 Lymphocyte counts; CRC cis rs77633900 0.772 rs75253262 chr15:76657124 G/A cg21673338 chr15:77095150 SCAPER -0.74 -6.88 -0.35 3e-11 Non-glioblastoma glioma;Glioma; CRC cis rs9611565 0.649 rs202625 chr22:41827082 G/A cg06481639 chr22:41940642 POLR3H 0.53 5.78 0.3 1.72e-8 Vitiligo; CRC cis rs7607369 0.782 rs639913 chr2:219365971 A/C cg02176678 chr2:219576539 TTLL4 0.54 8.69 0.43 1.78e-16 Red blood cell count;Amyotrophic lateral sclerosis; CRC cis rs4481887 0.893 rs1934544 chr1:248505582 G/A cg13385794 chr1:248469461 NA 0.35 6.39 0.33 5.79e-10 Common traits (Other); CRC cis rs950776 0.593 rs680244 chr15:78871288 T/C cg06917634 chr15:78832804 PSMA4 -0.57 -8.81 -0.44 7.32e-17 Sudden cardiac arrest; CRC cis rs8141797 0.892 rs176158 chr22:24513337 T/A cg20894457 chr22:24584366 SUSD2 0.61 8.07 0.41 1.3e-14 Amyotrophic lateral sclerosis;Coronary artery disease; CRC cis rs1862618 0.620 rs189695 chr5:56225769 T/C cg20203395 chr5:56204925 C5orf35 -0.59 -7.99 -0.4 2.32e-14 Initial pursuit acceleration; CRC trans rs17685 0.753 rs1574107 chr7:75685047 A/C cg19862616 chr7:65841803 NCRNA00174 0.99 18.42 0.71 1.48e-52 Coffee consumption;Coffee consumption (cups per day); CRC cis rs4481887 0.927 rs4292985 chr1:248473692 T/A cg13385794 chr1:248469461 NA 0.38 6.75 0.35 6.84e-11 Common traits (Other); CRC cis rs7584330 0.744 rs72620822 chr2:238379582 C/T cg14458575 chr2:238380390 NA 0.9 16.41 0.67 1.28e-44 Prostate cancer; CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg09755102 chr1:33283495 S100PBP;YARS -0.55 -6.64 -0.34 1.27e-10 Diisocyanate-induced asthma; CRC cis rs1552244 0.572 rs41464050 chr3:10158393 A/G cg02579736 chr3:10068473 FANCD2;CIDECP 0.99 11.43 0.53 1.09e-25 Alzheimer's disease; CRC cis rs17376456 1.000 rs56046246 chr5:93531545 T/G cg25358565 chr5:93447407 FAM172A 1.03 9.79 0.47 4.96e-20 Diabetic retinopathy; CRC cis rs1670533 1.000 rs10007978 chr4:1060984 A/T cg27284194 chr4:1044797 NA 0.5 6.22 0.32 1.51e-9 Recombination rate (females); CRC trans rs637571 0.522 rs503524 chr11:65751764 C/T cg17712092 chr4:129076599 LARP1B 0.7 11.79 0.54 5.48e-27 Eosinophil percentage of white cells; CRC cis rs896854 0.654 rs16893776 chr8:95973604 C/T cg09323728 chr8:95962352 TP53INP1 -0.46 -7.6 -0.39 3.02e-13 Type 2 diabetes; CRC cis rs10256972 0.552 rs2960831 chr7:1201192 A/T cg18765753 chr7:1198926 ZFAND2A -0.47 -8.39 -0.42 1.48e-15 Longevity;Endometriosis; CRC cis rs11997175 0.624 rs4526317 chr8:33682936 T/A cg04338863 chr8:33670619 NA 0.44 7.01 0.36 1.36e-11 Body mass index; CRC cis rs2836974 0.568 rs8130795 chr21:40549983 T/A cg06238570 chr21:40685208 BRWD1 0.84 13.47 0.6 3.09e-33 Cognitive function; CRC cis rs977987 0.806 rs11648176 chr16:75456423 C/G cg03315344 chr16:75512273 CHST6 0.54 9.12 0.45 7.66e-18 Dupuytren's disease; CRC cis rs10504229 0.679 rs11786328 chr8:58039269 A/G cg08219700 chr8:58056026 NA 0.52 6.09 0.32 3.18e-9 Developmental language disorder (linguistic errors); CRC trans rs73162807 0.655 rs73160912 chr3:146421626 A/G cg26896787 chr1:228603707 TRIM17 -0.59 -5.99 -0.31 5.61e-9 Platelet-derived growth factor BB levels; CRC cis rs17666538 1.000 rs59631161 chr8:587808 G/T cg07685180 chr8:600429 NA -0.81 -7.53 -0.38 4.99e-13 IgG glycosylation; CRC cis rs7208859 0.623 rs11650271 chr17:29213943 C/T cg13385521 chr17:29058706 SUZ12P 0.68 8.02 0.4 1.83e-14 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg22856972 chr6:134275178 TBPL1 0.43 6.02 0.31 4.55e-9 Thyroid stimulating hormone; CRC cis rs72781680 0.678 rs56145919 chr2:24088489 A/G cg08917208 chr2:24149416 ATAD2B 0.56 6.83 0.35 4.14e-11 Lymphocyte counts; CRC cis rs9326248 0.501 rs4938351 chr11:117022352 A/C cg15534755 chr11:117069859 TAGLN 0.3 5.88 0.31 1.01e-8 Blood protein levels; CRC cis rs2204008 0.837 rs10876019 chr12:37985477 C/T cg26384229 chr12:38710491 ALG10B 0.69 9.14 0.45 6.75e-18 Bladder cancer; CRC cis rs4908768 0.501 rs35865480 chr1:8603777 C/T cg20416874 chr1:8611966 RERE -0.46 -6.69 -0.35 9.65e-11 Neuroticism (multi-trait analysis);Subjective well-being (multi-trait analysis); CRC cis rs34172651 0.517 rs35560136 chr16:24788915 T/A cg00339695 chr16:24857497 SLC5A11 0.37 6.83 0.35 4.14e-11 Intelligence (multi-trait analysis); CRC cis rs1957429 0.572 rs3813421 chr14:65347239 G/A cg23373153 chr14:65346875 NA 0.79 8.25 0.41 3.9e-15 Pediatric areal bone mineral density (radius); CRC cis rs3087591 0.919 rs2285892 chr17:29553485 G/A cg24425628 chr17:29625626 OMG;NF1 -0.82 -15.79 -0.66 3.32e-42 Hip circumference; CRC cis rs8058578 1.000 rs7187359 chr16:30703155 G/A cg02466173 chr16:30829666 NA -0.67 -9.87 -0.48 2.79e-20 Multiple myeloma; CRC cis rs1046896 0.514 rs9894705 chr17:80823758 A/C cg03160526 chr17:80928410 B3GNTL1 -0.57 -7.88 -0.4 4.74e-14 Glycated hemoglobin levels; CRC cis rs9517320 0.534 rs9554474 chr13:99140871 G/A cg20487152 chr13:99095054 FARP1 -0.45 -6.57 -0.34 1.97e-10 Longevity; CRC cis rs7224685 0.501 rs4790559 chr17:4010478 G/T cg10724054 chr17:3904396 NA 0.47 7.59 0.39 3.36e-13 Type 2 diabetes; CRC cis rs4400599 0.618 rs4393149 chr1:154195753 G/A cg26808167 chr1:154192205 UBAP2L;C1orf43 -0.36 -5.71 -0.3 2.49e-8 Platelet distribution width; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg19036007 chr3:38496311 LOC100128640;ACVR2B 0.45 6.47 0.34 3.55e-10 Response to antipsychotic treatment; CRC cis rs13108904 0.870 rs12642797 chr4:1245990 G/A cg02018176 chr4:1364513 KIAA1530 0.44 7.37 0.38 1.42e-12 Obesity-related traits; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg09938328 chr1:39325620 RRAGC 0.34 6.75 0.35 6.63e-11 Liver disease severity in Alagille syndrome; CRC cis rs4332037 0.624 rs11764337 chr7:1892309 A/G cg25834613 chr7:1915315 MAD1L1 0.4 6.25 0.33 1.28e-9 Bipolar disorder; CRC cis rs9322193 0.923 rs9767123 chr6:149981459 A/G cg00933542 chr6:150070202 PCMT1 0.3 6.26 0.33 1.17e-9 Lung cancer; CRC cis rs870825 0.616 rs28607131 chr4:185651617 A/G cg04058563 chr4:185651563 MLF1IP 0.72 9.28 0.46 2.4e-18 Blood protein levels; CRC trans rs1005277 0.579 rs2472174 chr10:38375382 A/G cg23533926 chr12:111358616 MYL2 -0.52 -7.85 -0.4 6.09e-14 Extrinsic epigenetic age acceleration; CRC cis rs2938670 1 rs2938670 chr15:78740688 T/G cg18825076 chr15:78729989 IREB2 -0.46 -7.23 -0.37 3.33e-12 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1;Post bronchodilator FEV1 in COPD;Post bronchodilator FEV1/FVC ratio in COPD; CRC cis rs11628318 0.853 rs7155171 chr14:103031845 C/T cg23071808 chr14:103021642 NA -0.68 -8.98 -0.44 2.12e-17 Platelet count; CRC cis rs4713118 0.955 rs9380010 chr6:27683572 A/G cg20933634 chr6:27740509 NA 0.57 8.08 0.41 1.24e-14 Parkinson's disease; CRC cis rs477895 0.653 rs7102327 chr11:63908720 C/T cg18225595 chr11:63971243 STIP1 0.56 7.39 0.38 1.19e-12 Mean platelet volume; CRC cis rs1538970 1.000 rs4660852 chr1:45848931 A/C cg05343316 chr1:45956843 TESK2 -0.63 -8.98 -0.44 2.09e-17 Platelet count; CRC trans rs9467711 0.606 rs9348726 chr6:26605206 G/A cg06606381 chr12:133084897 FBRSL1 -0.85 -6.44 -0.33 4.18e-10 Autism spectrum disorder or schizophrenia; CRC cis rs7523050 0.643 rs34572569 chr1:109401856 A/T cg08274380 chr1:109419600 GPSM2 0.85 6.65 0.34 1.24e-10 Fat distribution (HIV); CRC cis rs847577 0.630 rs6967926 chr7:97715088 C/T cg21770322 chr7:97807741 LMTK2 0.84 19.12 0.73 2.59e-55 Breast cancer; CRC cis rs6665290 0.904 rs1045286 chr1:227179037 A/C cg10327440 chr1:227177885 CDC42BPA 1.04 24.15 0.8 7.29e-75 Myeloid white cell count; CRC trans rs8073060 0.544 rs225258 chr17:33956883 C/T cg19694781 chr19:47549865 TMEM160 -1.08 -15.68 -0.65 8.88e-42 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; CRC cis rs6484504 0.576 rs58702363 chr11:31246397 C/A cg14844989 chr11:31128820 NA -0.34 -6.14 -0.32 2.42e-9 Red blood cell count; CRC cis rs812925 0.519 rs2922089 chr2:61625129 T/G cg10580144 chr2:61372316 C2orf74 -0.33 -7.08 -0.36 8.84e-12 Immature fraction of reticulocytes; CRC cis rs6961069 0.777 rs4731643 chr7:80248029 A/G cg04458919 chr7:80252533 CD36 -0.35 -6.35 -0.33 7.36e-10 Platelet count; CRC cis rs12477438 1.000 rs6732980 chr2:99921613 A/G cg26064155 chr2:99771622 LIPT1;TSGA10 -0.76 -9.5 -0.46 4.43e-19 Chronic sinus infection; CRC cis rs7927771 0.864 rs7937331 chr11:47430458 T/C cg05585544 chr11:47624801 NA 0.47 8.48 0.42 7.86e-16 Subjective well-being; CRC cis rs1336900 0.513 rs56253522 chr1:150614869 C/A cg15448220 chr1:150897856 SETDB1 0.44 6.12 0.32 2.73e-9 Blood protein levels; CRC trans rs3747547 0.792 rs11790106 chr9:38047710 G/A cg15100947 chr1:6333867 ACOT7 0.76 5.97 0.31 6.2e-9 Metabolite levels (Dihydroxy docosatrienoic acid); CRC cis rs951366 0.764 rs708724 chr1:205743663 A/C cg07167872 chr1:205819463 PM20D1 0.78 12.17 0.56 2.2e-28 Menarche (age at onset); CRC cis rs6502050 0.698 rs67143649 chr17:80117772 C/G cg19223190 chr17:80058835 NA 0.38 6.17 0.32 2e-9 Life satisfaction; CRC cis rs9916302 0.904 rs6503507 chr17:37525274 C/T cg00129232 chr17:37814104 STARD3 0.53 7.9 0.4 4.13e-14 Glomerular filtration rate (creatinine); CRC cis rs11608355 0.506 rs11066471 chr12:109828039 T/C cg19025524 chr12:109796872 NA -0.51 -7.63 -0.39 2.58e-13 Neuroticism; CRC cis rs8017423 0.647 rs12883000 chr14:90820557 G/A cg14092571 chr14:90743983 NA 0.39 5.98 0.31 5.81e-9 Mortality in heart failure; CRC cis rs870825 0.929 rs72689261 chr4:185590897 C/A cg07424746 chr4:185654737 MLF1IP -0.59 -5.82 -0.31 1.4e-8 Blood protein levels; CRC cis rs6952808 0.689 rs11771625 chr7:2050401 C/T cg21782813 chr7:2030301 MAD1L1 0.55 9.59 0.47 2.33e-19 Bipolar disorder and schizophrenia; CRC cis rs6570726 0.791 rs6923074 chr6:145893332 T/C cg13319975 chr6:146136371 FBXO30 -0.42 -6.22 -0.32 1.53e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs2840044 0.534 rs167691 chr17:33885826 G/A cg05299278 chr17:33885742 SLFN14 0.51 8.34 0.42 2.12e-15 Response to radiotherapy in cancer (late toxicity); CRC cis rs10045504 0.502 rs10512692 chr5:38762993 G/A cg15396434 chr5:38725168 NA -0.63 -6.14 -0.32 2.32e-9 Night sleep phenotypes; CRC cis rs1150668 0.796 rs1005125 chr6:28367355 G/A cg25164649 chr6:28176230 NA 0.4 5.84 0.31 1.26e-8 Pubertal anthropometrics; CRC cis rs7258465 0.965 rs2385088 chr19:18545540 A/G cg01065977 chr19:18549689 ISYNA1 -0.42 -6.31 -0.33 8.76e-10 Breast cancer; CRC cis rs9549260 0.755 rs2721066 chr13:41156188 C/T cg21288729 chr13:41239152 FOXO1 -0.38 -5.92 -0.31 7.93e-9 Red blood cell count; CRC cis rs28386778 0.897 rs7221853 chr17:61859836 A/G cg06873352 chr17:61820015 STRADA 0.8 15.29 0.64 2.98e-40 Prudent dietary pattern; CRC cis rs10751667 0.666 rs10794354 chr11:954615 A/T cg06064525 chr11:970664 AP2A2 -0.31 -6.28 -0.33 1.07e-9 Alzheimer's disease (late onset); CRC cis rs9914988 0.606 rs968726 chr17:27194634 A/G cg16670446 chr17:27188758 MIR451;MIR144 0.41 7.4 0.38 1.15e-12 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs60871478 0.947 rs62432866 chr7:809281 T/G cg05535760 chr7:792225 HEATR2 0.8 10.6 0.5 8.79e-23 Cerebrospinal P-tau181p levels; CRC cis rs7615952 0.641 rs7618515 chr3:125790578 C/T cg05084668 chr3:125655381 ALG1L -0.45 -6.54 -0.34 2.41e-10 Blood pressure (smoking interaction); CRC trans rs61931739 0.534 rs1608912 chr12:34008574 C/T cg26384229 chr12:38710491 ALG10B 0.51 7.08 0.36 9.03e-12 Morning vs. evening chronotype; CRC cis rs2732480 0.577 rs2634691 chr12:48708259 G/T cg04545296 chr12:48745243 ZNF641 0.36 6.0 0.31 5.27e-9 Hemoglobin concentration;Red blood cell count;Hematocrit; CRC cis rs10504229 0.593 rs17794451 chr8:58019217 C/T cg11062466 chr8:58055876 NA 0.53 6.58 0.34 1.85e-10 Developmental language disorder (linguistic errors); CRC cis rs10781543 0.839 rs6560632 chr9:139371786 A/C cg14019695 chr9:139328340 INPP5E 0.42 6.21 0.32 1.61e-9 Monocyte percentage of white cells; CRC cis rs10865541 0.869 rs6711292 chr2:3422170 A/T cg22182287 chr2:3452347 TTC15 0.38 5.92 0.31 7.94e-9 Obesity-related traits; CRC cis rs1707322 1.000 rs1622208 chr1:46498375 A/G cg06784218 chr1:46089804 CCDC17 -0.6 -10.71 -0.51 3.73e-23 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs1348850 0.872 rs12991272 chr2:178457339 T/C cg22681709 chr2:178499509 PDE11A -0.35 -6.27 -0.33 1.12e-9 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs8141797 0.901 rs176159 chr22:24514352 A/G cg20894457 chr22:24584366 SUSD2 -0.6 -7.21 -0.37 3.78e-12 Amyotrophic lateral sclerosis;Coronary artery disease; CRC cis rs2842992 0.915 rs2842985 chr6:160085434 C/T cg16489826 chr6:160211363 TCP1;MRPL18 0.49 5.74 0.3 2.21e-8 Age-related macular degeneration (geographic atrophy); CRC cis rs4308124 0.708 rs6727313 chr2:111971540 G/A cg04571233 chr2:111982156 NA -0.56 -8.22 -0.41 4.69e-15 Vitiligo; CRC cis rs1957429 0.731 rs1951495 chr14:65336690 T/C cg23373153 chr14:65346875 NA 0.8 6.87 0.35 3.15e-11 Pediatric areal bone mineral density (radius); CRC trans rs10838798 0.504 rs11039632 chr11:48297280 C/T cg21153622 chr11:89784906 NA -0.5 -8.29 -0.42 2.93e-15 Height; CRC cis rs765787 0.530 rs4444275 chr15:45535347 T/C cg24006582 chr15:45444508 DUOX1 -0.57 -8.79 -0.44 8.5e-17 Uric acid levels; CRC cis rs16975963 0.644 rs73035164 chr19:38146720 G/C cg15135657 chr19:38346511 NA -0.46 -6.33 -0.33 7.87e-10 Longevity; CRC cis rs939658 0.805 rs35484723 chr15:79441032 A/G cg17916960 chr15:79447300 NA -0.43 -7.04 -0.36 1.09e-11 Refractive error; CRC cis rs5769765 0.773 rs9616383 chr22:50313014 T/C cg02269571 chr22:50332266 NA -0.61 -7.92 -0.4 3.64e-14 Schizophrenia; CRC trans rs3806843 0.838 rs2262567 chr5:140132134 T/A cg06840491 chr10:48416966 GDF2 -0.35 -6.04 -0.32 4.16e-9 Depressive symptoms (multi-trait analysis); CRC trans rs3733585 0.699 rs6449174 chr4:9966422 C/T cg26043149 chr18:55253948 FECH -0.48 -7.28 -0.37 2.51e-12 Cleft plate (environmental tobacco smoke interaction); CRC cis rs10540 1.000 rs35231079 chr11:515224 G/A cg19913688 chr11:428466 ANO9 -0.69 -7.03 -0.36 1.22e-11 Body mass index; CRC cis rs7945705 0.747 rs11042150 chr11:9010819 T/C cg21881798 chr11:8931708 C11orf17;ST5 -0.68 -11.84 -0.55 3.39e-27 Hemoglobin concentration; CRC trans rs7615952 0.673 rs16834637 chr3:125605471 C/T cg07211511 chr3:129823064 LOC729375 -1.03 -12.61 -0.57 5.01e-30 Blood pressure (smoking interaction); CRC cis rs11190604 1.000 rs10883508 chr10:102294413 G/A cg16342193 chr10:102329863 NA -0.35 -5.84 -0.31 1.25e-8 Palmitoleic acid (16:1n-7) levels; CRC cis rs6831352 0.918 rs2851246 chr4:100046104 A/G cg13256891 chr4:100009986 ADH5 0.65 8.87 0.44 4.59e-17 Alcohol dependence; CRC cis rs8077889 1.000 rs17674998 chr17:41879544 A/G cg25876840 chr17:41920477 NA 0.53 7.43 0.38 9.37e-13 Triglycerides; CRC trans rs11098499 0.710 rs4145952 chr4:120155806 C/A cg25214090 chr10:38739885 LOC399744 0.4 6.32 0.33 8.52e-10 Corneal astigmatism; CRC cis rs7726839 0.540 rs11750321 chr5:599196 C/T cg14541582 chr5:601475 NA -0.37 -7.38 -0.38 1.27e-12 Obesity-related traits; CRC cis rs3820068 0.581 rs59991988 chr1:15950552 T/A cg13390004 chr1:15929781 NA 0.5 7.08 0.36 8.59e-12 Systolic blood pressure; CRC cis rs6912958 0.558 rs7741825 chr6:88327338 G/C cg08069147 chr6:88032118 GJB7;C6orf162 -0.54 -8.2 -0.41 5.44e-15 Monocyte percentage of white cells; CRC cis rs6840360 0.642 rs12647555 chr4:152401098 A/T cg09659197 chr4:152720779 NA 0.34 6.65 0.34 1.24e-10 Intelligence (multi-trait analysis); CRC cis rs12745968 0.589 rs912796 chr1:92961410 C/T cg17283838 chr1:93427260 FAM69A -0.46 -6.27 -0.33 1.11e-9 Bipolar disorder and schizophrenia; CRC cis rs1865760 0.865 rs9467641 chr6:25947236 T/C cg17691542 chr6:26056736 HIST1H1C 0.52 7.7 0.39 1.63e-13 Height; CRC cis rs68170813 0.559 rs56933300 chr7:106953278 A/AGGACCTCGGCAGAAGCC cg02696742 chr7:106810147 HBP1 -0.58 -6.08 -0.32 3.41e-9 Coronary artery disease; CRC cis rs2885056 0.783 rs73007347 chr19:10650649 C/T cg06392426 chr19:10676186 KRI1 0.56 6.44 0.33 4.25e-10 Red cell distribution width; CRC cis rs6860806 0.507 rs274570 chr5:131713226 C/T cg09877947 chr5:131593287 PDLIM4 -0.44 -7.13 -0.37 6.36e-12 Breast cancer; CRC cis rs1008375 1.000 rs9991307 chr4:17662408 A/G cg16339924 chr4:17578868 LAP3 0.55 7.14 0.37 6.01e-12 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs9611565 0.659 rs9611602 chr22:41908405 T/C cg03806693 chr22:41940476 POLR3H -1.11 -15.12 -0.64 1.43e-39 Vitiligo; CRC cis rs4132509 1.000 rs73124169 chr1:243804939 T/C cg21452805 chr1:244014465 NA 0.51 6.89 0.36 2.87e-11 RR interval (heart rate); CRC cis rs853679 0.517 rs9468297 chr6:28118874 G/T cg23161317 chr6:28129485 ZNF389 0.53 6.43 0.33 4.52e-10 Depression; CRC cis rs9443645 0.901 rs1542977 chr6:79550307 G/T cg09184832 chr6:79620586 NA -0.49 -9.18 -0.45 5e-18 Intelligence (multi-trait analysis); CRC cis rs9486719 1.000 rs12208884 chr6:96885572 G/A cg06623918 chr6:96969491 KIAA0776 -0.81 -9.51 -0.46 4.17e-19 Migraine;Coronary artery disease; CRC cis rs1799949 1.000 rs8074136 chr17:41342313 A/C cg05368731 chr17:41323189 NBR1 0.68 10.29 0.49 1.05e-21 Menopause (age at onset); CRC cis rs7727544 0.716 rs72793283 chr5:131566941 G/A cg11843238 chr5:131593191 PDLIM4 0.35 6.64 0.34 1.28e-10 Blood metabolite levels; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg20227886 chr18:48405353 ME2 0.37 6.08 0.32 3.38e-9 Liver disease severity in Alagille syndrome; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg07326768 chr15:86337453 KLHL25 0.51 7.35 0.38 1.55e-12 Response to antipsychotic treatment; CRC cis rs10540 1.000 rs35996687 chr11:458595 G/A cg15790184 chr11:494944 RNH1 0.62 5.96 0.31 6.67e-9 Body mass index; CRC cis rs1499614 1.000 rs2707828 chr7:66171377 G/A cg12463550 chr7:65579703 CRCP 0.64 5.79 0.3 1.66e-8 Gout; CRC cis rs754466 0.580 rs12354903 chr10:79536465 T/C cg17075019 chr10:79541650 NA -0.99 -19.5 -0.73 7.89e-57 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs765787 0.530 rs2458224 chr15:45522130 T/C cg24006582 chr15:45444508 DUOX1 -0.56 -8.55 -0.43 4.67e-16 Uric acid levels; CRC cis rs6867032 1.000 rs4975794 chr5:2015330 A/G cg26168224 chr5:2018326 NA -1.02 -19.87 -0.74 2.83e-58 Gut microbiome composition (winter); CRC cis rs6089584 0.850 rs6089634 chr20:60632566 T/C cg06108461 chr20:60628389 TAF4 -0.92 -15.85 -0.66 2.02e-42 Body mass index; CRC cis rs9326248 0.813 rs4938350 chr11:117022276 A/G cg26566898 chr11:117069891 TAGLN 0.39 7.02 0.36 1.24e-11 Blood protein levels; CRC trans rs4650994 1.000 rs4650995 chr1:178517316 C/T cg05059571 chr16:84539110 KIAA1609 -0.48 -7.33 -0.37 1.83e-12 HDL cholesterol levels;HDL cholesterol; CRC cis rs2857891 0.909 rs17191140 chr11:6944283 G/A cg06872519 chr11:6947619 ZNF215 0.6 5.9 0.31 9.15e-9 Response to cytadine analogues (cytosine arabinoside); CRC cis rs9388451 0.874 rs1159974 chr6:126090277 C/T cg05901451 chr6:126070800 HEY2 0.64 11.14 0.52 1.17e-24 Brugada syndrome; CRC cis rs7208859 0.673 rs55904046 chr17:29215391 G/A cg13385521 chr17:29058706 SUZ12P 0.68 8.02 0.4 1.83e-14 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs68170813 0.559 rs58319984 chr7:106965794 G/A cg02696742 chr7:106810147 HBP1 -0.59 -6.53 -0.34 2.45e-10 Coronary artery disease; CRC cis rs2439831 0.702 rs3759791 chr15:44090798 T/C cg15269541 chr15:43626905 ADAL -0.51 -5.82 -0.31 1.36e-8 Lung cancer in ever smokers; CRC cis rs10504229 0.906 rs113857287 chr8:58191683 T/C cg01721255 chr8:58191610 C8orf71 0.5 6.17 0.32 2.06e-9 Developmental language disorder (linguistic errors); CRC cis rs2797160 1.000 rs6904069 chr6:125995134 C/T cg05901451 chr6:126070800 HEY2 -0.39 -5.97 -0.31 6.15e-9 Endometrial cancer; CRC cis rs868943 0.714 rs66475830 chr6:116408802 T/C cg18764771 chr6:116381957 FRK 0.26 6.14 0.32 2.4e-9 Total cholesterol levels; CRC cis rs9818758 0.556 rs9813813 chr3:49207093 T/A cg00383909 chr3:49044727 WDR6 1.39 12.45 0.57 2.08e-29 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; CRC trans rs12478296 1.000 rs56102931 chr2:243039936 A/G cg18288967 chr1:45987694 PRDX1 0.68 7.48 0.38 6.93e-13 Obesity-related traits; CRC cis rs4332037 0.624 rs11764124 chr7:1891723 C/G cg23422044 chr7:1970798 MAD1L1 -0.5 -6.61 -0.34 1.59e-10 Bipolar disorder; CRC cis rs4434138 0.683 rs13063160 chr3:52602274 T/C cg11645453 chr3:52864694 ITIH4 0.34 6.21 0.32 1.57e-9 Intelligence (multi-trait analysis); CRC cis rs763121 0.889 rs9610971 chr22:38910810 C/T cg06022373 chr22:39101656 GTPBP1 0.74 10.77 0.51 2.35e-23 Menopause (age at onset); CRC cis rs3760982 1.000 rs4803658 chr19:44290013 T/A cg12072164 chr19:44306565 LYPD5 0.41 6.47 0.34 3.62e-10 Breast cancer (estrogen-receptor negative);Breast cancer; CRC cis rs870825 0.616 rs3184982 chr4:185615768 T/G cg04058563 chr4:185651563 MLF1IP 0.72 9.2 0.45 4.12e-18 Blood protein levels; CRC trans rs2303319 0.504 rs56009150 chr2:162598582 T/C cg05865860 chr7:158649142 WDR60 -0.71 -5.97 -0.31 6.26e-9 Cognitive function; CRC cis rs4731207 0.596 rs7795611 chr7:124578456 G/C cg23710748 chr7:124431027 NA -0.39 -6.1 -0.32 2.94e-9 Cutaneous malignant melanoma; CRC cis rs3540 0.960 rs11853271 chr15:91025830 C/T cg22089800 chr15:90895588 ZNF774 0.48 7.82 0.4 7.27e-14 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg16280098 chr14:23790882 PABPN1 0.41 7.0 0.36 1.41e-11 Liver disease severity in Alagille syndrome; CRC cis rs4713118 0.621 rs9295756 chr6:28033396 G/T cg23161317 chr6:28129485 ZNF389 0.49 6.11 0.32 2.81e-9 Parkinson's disease; CRC trans rs916888 0.821 rs199509 chr17:44858728 G/A cg22968622 chr17:43663579 NA -1.2 -15.72 -0.65 6.5e-42 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs600806 0.888 rs3879449 chr1:109904971 A/T cg23032129 chr1:109941072 SORT1 -0.28 -6.01 -0.31 5.02e-9 Intelligence (multi-trait analysis); CRC cis rs8177253 1.000 rs8177261 chr3:133480588 A/C cg08048268 chr3:133502702 NA -0.36 -6.81 -0.35 4.74e-11 Iron status biomarkers; CRC cis rs2734839 0.964 rs1800498 chr11:113291588 G/A cg14159747 chr11:113255604 NA 0.46 8.1 0.41 1.12e-14 Information processing speed; CRC cis rs12474201 0.894 rs34401107 chr2:46972768 A/C cg06386533 chr2:46925753 SOCS5 0.78 13.15 0.59 4.86e-32 Height; CRC cis rs2495707 0.624 rs2489008 chr10:102422934 C/T cg08729031 chr10:102416179 NA -0.42 -7.56 -0.38 3.98e-13 Body mass index; CRC trans rs1005277 0.579 rs2504143 chr10:38383706 C/T cg17830980 chr10:43048298 ZNF37B -0.6 -9.95 -0.48 1.5e-20 Extrinsic epigenetic age acceleration; CRC cis rs12898370 0.561 rs11630770 chr15:77469643 A/G cg10437265 chr15:77819839 NA -0.56 -6.37 -0.33 6.26e-10 Risky sexual behaviors (alcohol dependence interaction); CRC cis rs10540 1.000 rs35231079 chr11:515224 G/A cg08200582 chr11:442649 ANO9 -0.71 -7.39 -0.38 1.2e-12 Body mass index; CRC cis rs7537052 0.564 rs6669395 chr1:36653717 A/G cg25304816 chr1:36627734 MAP7D1 0.41 6.39 0.33 5.79e-10 Schizophrenia; CRC cis rs28374715 0.532 rs3204853 chr15:41689166 C/A cg18705301 chr15:41695430 NDUFAF1 -1.15 -19.39 -0.73 2.19e-56 Ulcerative colitis; CRC cis rs2836950 0.545 rs1888489 chr21:40533164 T/C cg06238570 chr21:40685208 BRWD1 -0.63 -9.39 -0.46 1.04e-18 Menarche (age at onset); CRC cis rs3617 0.598 rs56214994 chr3:52878600 G/C cg11645453 chr3:52864694 ITIH4 -0.46 -9.31 -0.46 1.92e-18 Red blood cell count;Autism spectrum disorder or schizophrenia; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg05255807 chr6:88411528 NCRNA00120;AKIRIN2 -0.44 -6.55 -0.34 2.17e-10 Myopia (pathological); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg26821823 chr11:75875926 NA -0.37 -6.48 -0.34 3.42e-10 Liver disease severity in Alagille syndrome; CRC cis rs79839061 0.563 rs55728587 chr4:843674 G/A cg14530993 chr4:882597 GAK 0.82 7.7 0.39 1.64e-13 Intelligence (multi-trait analysis); CRC cis rs12413816 0.784 rs11258560 chr10:13770137 A/G cg16485048 chr10:13749193 FRMD4A 0.5 7.63 0.39 2.56e-13 Red cell distribution width; CRC cis rs9443645 0.901 rs9343856 chr6:79678211 G/A cg05283184 chr6:79620031 NA -0.6 -9.35 -0.46 1.35e-18 Intelligence (multi-trait analysis); CRC cis rs7584330 0.518 rs74003103 chr2:238446699 G/A cg08992911 chr2:238395768 MLPH 0.61 6.27 0.33 1.13e-9 Prostate cancer; CRC cis rs2635047 0.967 rs2576060 chr18:44637106 C/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 -0.49 -8.12 -0.41 9.36e-15 Educational attainment; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg02769794 chr10:79686682 LOC100128292;DLG5 0.41 6.3 0.33 9.81e-10 Liver disease severity in Alagille syndrome; CRC cis rs2629540 0.847 rs34032724 chr10:126408869 T/G cg08799069 chr10:126477246 METTL10 0.63 7.98 0.4 2.4e-14 Cocaine dependence; CRC cis rs10193935 0.892 rs13413028 chr2:42394865 C/G cg27598129 chr2:42591480 NA -0.7 -7.9 -0.4 4.3e-14 Colonoscopy-negative controls vs population controls; CRC trans rs1814175 0.817 rs10769617 chr11:49810421 G/A cg21153622 chr11:89784906 NA -0.38 -6.04 -0.32 4.13e-9 Height; CRC trans rs11098499 0.954 rs10006525 chr4:120408931 T/G cg25214090 chr10:38739885 LOC399744 0.64 10.35 0.5 6.24e-22 Corneal astigmatism; CRC cis rs4780401 0.609 rs12927966 chr16:11814562 C/T cg01061890 chr16:11836724 TXNDC11 -0.62 -9.27 -0.46 2.44e-18 Rheumatoid arthritis; CRC cis rs11577318 0.853 rs7537477 chr1:26618829 C/T cg04990556 chr1:26633338 UBXN11 -0.49 -6.17 -0.32 2.06e-9 Granulocyte percentage of myeloid white cells; CRC cis rs6604026 0.656 rs2811591 chr1:93363951 C/A cg17283838 chr1:93427260 FAM69A -0.43 -5.79 -0.3 1.61e-8 Multiple sclerosis; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg12857786 chr4:83934023 LIN54 0.42 6.15 0.32 2.24e-9 Intelligence (multi-trait analysis); CRC cis rs9303280 0.936 rs12950209 chr17:38049102 T/C cg20243544 chr17:37824526 PNMT 0.43 6.64 0.34 1.3e-10 Self-reported allergy; CRC cis rs4903604 0.513 rs12880891 chr14:78035233 T/C cg18872420 chr14:78023429 SPTLC2 0.34 5.92 0.31 7.9e-9 Gut microbiome composition (winter); CRC cis rs7662987 0.517 rs2851265 chr4:100029684 A/G cg12011299 chr4:100065546 ADH4 0.49 9.2 0.45 4.13e-18 Smoking initiation; CRC cis rs79387448 0.745 rs6749440 chr2:103101846 C/T cg09003973 chr2:102972529 NA 0.68 7.37 0.38 1.36e-12 Gut microbiota (bacterial taxa); CRC cis rs67311347 1.000 rs9860162 chr3:40403875 C/T cg09455208 chr3:40491958 NA 0.44 8.82 0.44 6.83e-17 Renal cell carcinoma; CRC cis rs10744422 0.858 rs12426809 chr12:123327143 C/T cg25930673 chr12:123319894 HIP1R -0.54 -5.87 -0.31 1.04e-8 Schizophrenia; CRC cis rs2841233 0.692 rs2028416 chr14:105348552 C/T cg25073967 chr14:105360327 KIAA0284 -0.36 -5.64 -0.3 3.69e-8 IgG glycosylation; CRC cis rs7659604 0.846 rs35986491 chr4:122664528 A/T cg19748678 chr4:122722346 EXOSC9 0.56 9.0 0.44 1.79e-17 Type 2 diabetes; CRC cis rs929354 1.000 rs1182410 chr7:157063837 C/T cg17757837 chr7:157058334 UBE3C -0.82 -14.97 -0.64 5.33e-39 Body mass index; CRC cis rs875971 0.862 rs801194 chr7:66028495 T/C cg18252515 chr7:66147081 NA 0.43 6.23 0.32 1.44e-9 Aortic root size; CRC trans rs1728785 0.792 rs1111502 chr16:68581209 A/G cg04657470 chr2:198365150 HSPE1;HSPD1 0.59 7.13 0.37 6.23e-12 Ulcerative colitis; CRC cis rs68170813 0.599 rs6466162 chr7:106902625 C/T cg02696742 chr7:106810147 HBP1 -0.63 -7.01 -0.36 1.32e-11 Coronary artery disease; CRC trans rs6550704 0.687 rs9865314 chr3:22634337 A/G cg22833807 chr22:36925177 EIF3D -0.43 -6.41 -0.33 4.94e-10 Daytime sleep phenotypes; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg23469188 chr7:108166441 PNPLA8 0.4 6.95 0.36 2e-11 Liver disease severity in Alagille syndrome; CRC cis rs853679 0.517 rs9283884 chr6:28135660 C/G cg18032046 chr6:28092343 ZSCAN16 0.55 6.35 0.33 7.07e-10 Depression; CRC cis rs25422 0.938 rs62424176 chr6:118798602 T/C cg18833306 chr6:118973337 C6orf204 0.44 5.7 0.3 2.66e-8 Renal cell carcinoma; CRC cis rs71403859 0.730 rs17355804 chr16:71717214 A/G cg08717414 chr16:71523259 ZNF19 -0.99 -9.52 -0.46 3.9e-19 Post bronchodilator FEV1; CRC cis rs3752962 0.569 rs3803806 chr17:1940713 T/C cg24156229 chr17:1948635 NA -0.77 -14.7 -0.63 5.9e-38 Itch intensity from mosquito bite; CRC cis rs6951245 0.744 rs1133122 chr7:1192572 C/A cg21664854 chr7:1097933 C7orf50;GPR146 0.7 8.25 0.41 3.98e-15 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs78456975 0.628 rs13426896 chr2:1554768 C/T cg12573674 chr2:1569213 NA -0.81 -8.88 -0.44 4.38e-17 Placebo response in major depressive disorder (% change in symptom score); CRC cis rs910316 1.000 rs12897094 chr14:75579416 C/T cg11812906 chr14:75593930 NEK9 0.59 9.35 0.46 1.41e-18 Height; CRC cis rs853679 0.517 rs9368551 chr6:28061792 A/G cg21251018 chr6:28226885 NKAPL 0.48 6.22 0.32 1.55e-9 Depression; CRC cis rs4974559 0.947 rs10000012 chr4:1357325 C/G cg02980000 chr4:1222292 CTBP1 -0.69 -8.06 -0.41 1.47e-14 Systolic blood pressure; CRC cis rs1799949 0.501 rs35399157 chr17:41411602 G/C cg23758822 chr17:41437982 NA 0.79 13.4 0.59 5.5e-33 Menopause (age at onset); CRC cis rs881375 0.934 rs1468671 chr9:123657502 C/G cg09586646 chr9:123605570 PSMD5;LOC253039 0.47 6.36 0.33 6.73e-10 Rheumatoid arthritis; CRC cis rs2120019 1.000 rs7168680 chr15:75369212 G/A cg17294928 chr15:75287854 SCAMP5 -0.73 -10.92 -0.52 6.61e-24 Blood trace element (Zn levels); CRC trans rs9291683 0.632 rs11734375 chr4:10046298 A/G cg26043149 chr18:55253948 FECH 0.53 8.17 0.41 6.79e-15 Bone mineral density; CRC cis rs891088 0.622 rs11670932 chr19:7206790 A/G cg00428638 chr19:7224713 INSR -0.62 -7.6 -0.39 3.11e-13 Hip circumference adjusted for BMI;Height; CRC cis rs1816752 0.905 rs8002309 chr13:24976355 C/T cg02811702 chr13:24901961 NA 0.42 5.82 0.31 1.41e-8 Obesity-related traits; CRC cis rs2252790 1.000 rs2501050 chr6:116663206 G/A cg18764771 chr6:116381957 FRK -0.22 -5.8 -0.3 1.59e-8 Fast beta electroencephalogram; CRC cis rs6502050 0.805 rs7503095 chr17:80107354 G/A cg11859384 chr17:80120422 CCDC57 -0.37 -5.85 -0.31 1.16e-8 Life satisfaction; CRC trans rs16846053 0.786 rs62187567 chr2:162363066 G/A cg09481857 chr22:21368659 P2RX6;MGC16703 -0.64 -6.11 -0.32 2.75e-9 Blood osmolality (transformed sodium); CRC cis rs13118159 0.836 rs2293630 chr4:1342521 G/A cg15763984 chr4:1342303 KIAA1530 0.51 9.0 0.44 1.82e-17 Longevity; CRC cis rs3733585 0.699 rs4408959 chr4:9948868 C/T cg11266682 chr4:10021025 SLC2A9 -0.46 -9.15 -0.45 6.28e-18 Cleft plate (environmental tobacco smoke interaction); CRC cis rs2882667 0.690 rs700620 chr5:138097936 C/T cg09476006 chr5:138032270 NA -0.59 -10.52 -0.5 1.7e-22 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs367943 1.000 rs348941 chr5:112824166 G/C cg12552261 chr5:112820674 MCC -0.47 -6.93 -0.36 2.18e-11 Type 2 diabetes; CRC cis rs9486715 0.838 rs9386576 chr6:96954717 C/T cg18709589 chr6:96969512 KIAA0776 0.49 7.2 0.37 4.09e-12 Headache; CRC cis rs769267 0.895 rs2965182 chr19:19548246 A/G cg03709012 chr19:19516395 GATAD2A 0.74 11.63 0.54 2.1e-26 Tonsillectomy; CRC trans rs1005277 0.579 rs2474594 chr10:38426661 G/C cg27523141 chr10:43048294 ZNF37B 0.49 7.19 0.37 4.44e-12 Extrinsic epigenetic age acceleration; CRC cis rs9372498 0.536 rs9489399 chr6:118767147 C/A cg18833306 chr6:118973337 C6orf204 0.44 5.81 0.31 1.48e-8 Diastolic blood pressure; CRC cis rs1448094 0.512 rs61930864 chr12:86246740 G/A cg25456477 chr12:86230367 RASSF9 0.34 6.01 0.31 4.96e-9 Major depressive disorder; CRC cis rs425277 0.585 rs2222217 chr1:2063164 G/A cg24578937 chr1:2090814 PRKCZ -0.45 -7.92 -0.4 3.76e-14 Height; CRC cis rs6684514 1.000 rs10494304 chr1:156285764 C/G cg16558208 chr1:156270281 VHLL -0.55 -8.62 -0.43 2.83e-16 Mean corpuscular hemoglobin concentration;Glycated hemoglobin levels; CRC cis rs853679 0.599 rs202906 chr6:28011652 C/T cg06470822 chr6:28175283 NA -0.77 -7.39 -0.38 1.19e-12 Depression; CRC cis rs17166499 0.634 rs73070111 chr7:12874767 A/C cg12945054 chr7:12841881 NA 0.48 5.91 0.31 8.55e-9 Bipolar disorder and schizophrenia; CRC cis rs208520 0.608 rs3846803 chr6:66805743 C/A cg07460842 chr6:66804631 NA -1.09 -15.3 -0.64 2.69e-40 Exhaled nitric oxide output; CRC cis rs9486719 1.000 rs2472895 chr6:96870387 A/T cg06623918 chr6:96969491 KIAA0776 0.81 9.48 0.46 5.18e-19 Migraine;Coronary artery disease; CRC cis rs13256369 1.000 rs10095733 chr8:8574646 A/G cg00074818 chr8:8560427 CLDN23 0.35 6.49 0.34 3.08e-10 Obesity-related traits; CRC cis rs9549328 0.700 rs3011473 chr13:113618096 A/G cg08614441 chr13:113633676 MCF2L 0.42 7.31 0.37 1.98e-12 Systolic blood pressure; CRC cis rs6570726 0.791 rs425999 chr6:145819370 C/A cg05347473 chr6:146136440 FBXO30 0.4 6.23 0.32 1.45e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs898097 0.585 rs9893200 chr17:80893028 A/C cg15369054 chr17:80825471 TBCD -0.35 -5.8 -0.3 1.55e-8 Breast cancer; CRC cis rs6570726 0.764 rs451108 chr6:145844309 T/C cg23711669 chr6:146136114 FBXO30 0.74 12.89 0.58 4.51e-31 Lobe attachment (rater-scored or self-reported); CRC cis rs919433 1.000 rs6761919 chr2:198163328 A/G cg10820045 chr2:198174542 NA -0.57 -11.41 -0.53 1.23e-25 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC cis rs208520 0.955 rs208538 chr6:66964492 C/G cg07460842 chr6:66804631 NA -0.92 -11.43 -0.53 1.04e-25 Exhaled nitric oxide output; CRC cis rs3858526 0.959 rs61876223 chr11:5943393 G/A cg05234568 chr11:5960015 NA -0.58 -8.04 -0.41 1.67e-14 DNA methylation (variation); CRC cis rs17362650 0.653 rs35968355 chr2:9551713 G/A cg12832956 chr2:9616023 IAH1 -0.51 -6.64 -0.34 1.27e-10 Alcohol dependence (age at onset); CRC cis rs8072100 0.817 rs9912101 chr17:45547078 A/G cg08085267 chr17:45401833 C17orf57 -0.62 -10.01 -0.48 9.09e-21 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs6951245 1.000 rs79765398 chr7:1073764 A/G cg24642844 chr7:1081250 C7orf50 -0.79 -9.43 -0.46 7.57e-19 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs7772486 0.875 rs863820 chr6:146347402 C/T cg13319975 chr6:146136371 FBXO30 0.37 5.67 0.3 3.13e-8 Lobe attachment (rater-scored or self-reported); CRC cis rs7493 0.853 rs11770901 chr7:95054480 T/C cg07404485 chr7:94953653 PON1 -0.47 -6.09 -0.32 3.16e-9 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs2562152 0.744 rs216597 chr16:106777 G/C cg02949481 chr16:131562 MPG 0.53 6.05 0.32 3.86e-9 Glioblastoma; CRC cis rs10504229 1.000 rs61212428 chr8:58173963 G/A cg02725872 chr8:58115012 NA -0.38 -6.43 -0.33 4.44e-10 Developmental language disorder (linguistic errors); CRC cis rs728616 0.702 rs78734698 chr10:81756449 G/A cg11900509 chr10:81946545 ANXA11 -0.69 -6.76 -0.35 6.43e-11 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs8031584 0.697 rs798080 chr15:31122169 T/C cg14829155 chr15:31115871 NA 0.63 10.07 0.49 5.89e-21 Huntington's disease progression; CRC cis rs9303542 0.527 rs8074125 chr17:46610060 G/T cg04904318 chr17:46607828 HOXB1 -0.54 -6.26 -0.33 1.18e-9 Ovarian cancer;Epithelial ovarian cancer; CRC cis rs916888 0.610 rs199530 chr17:44836653 C/T cg15921436 chr17:44337874 NA -0.51 -6.77 -0.35 5.77e-11 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs13108904 0.967 rs13149715 chr4:1278255 C/A cg16405210 chr4:1374714 KIAA1530 -0.46 -6.34 -0.33 7.54e-10 Obesity-related traits; CRC cis rs853679 0.517 rs868987 chr6:28110148 A/G cg06470822 chr6:28175283 NA -1.01 -13.81 -0.61 1.54e-34 Depression; CRC cis rs9925964 0.900 rs9934438 chr16:31104878 G/A cg02466173 chr16:30829666 NA 0.41 5.65 0.3 3.43e-8 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs7072216 0.727 rs942807 chr10:100168219 G/A cg26618903 chr10:100175079 PYROXD2 -0.55 -9.26 -0.45 2.73e-18 Metabolite levels; CRC cis rs1451375 0.572 rs66792686 chr7:50651239 T/C cg14593290 chr7:50529359 DDC 0.57 7.3 0.37 2.24e-12 Malaria; CRC cis rs10504229 0.724 rs72650827 chr8:58126884 A/T cg05313129 chr8:58192883 C8orf71 -0.43 -6.11 -0.32 2.74e-9 Developmental language disorder (linguistic errors); CRC cis rs938554 0.692 rs6449213 chr4:9994215 A/G cg00071950 chr4:10020882 SLC2A9 -0.48 -6.32 -0.33 8.48e-10 Blood metabolite levels; CRC cis rs72781680 0.566 rs72796106 chr2:23901362 A/C cg08917208 chr2:24149416 ATAD2B 0.67 6.72 0.35 8.07e-11 Lymphocyte counts; CRC cis rs2969070 1.000 rs2969070 chr7:2512545 C/T cg03277898 chr7:2518824 NA -0.45 -6.95 -0.36 2.02e-11 Diastolic blood pressure; CRC cis rs7918232 0.941 rs1753415 chr10:27395102 T/C cg14240646 chr10:27532245 ACBD5 -0.82 -9.19 -0.45 4.62e-18 Breast cancer; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg11292385 chr22:29138453 CHEK2;HSCB 0.47 6.11 0.32 2.83e-9 Thyroid stimulating hormone; CRC cis rs2075371 1.000 rs2075373 chr7:133984683 A/C cg11752832 chr7:134001865 SLC35B4 0.5 7.75 0.39 1.19e-13 Mean platelet volume; CRC cis rs1799949 0.965 rs4793234 chr17:41436183 A/G cg05368731 chr17:41323189 NBR1 0.66 9.79 0.48 4.93e-20 Menopause (age at onset); CRC cis rs6772849 0.896 rs35535737 chr3:128383406 G/A cg08795948 chr3:128337044 NA 0.35 6.19 0.32 1.75e-9 Monocyte percentage of white cells;Monocyte count; CRC cis rs4862750 0.872 rs1991254 chr4:187875375 T/G cg22105103 chr4:187893119 NA 0.65 11.52 0.54 4.89e-26 Lobe attachment (rater-scored or self-reported); CRC cis rs7572644 0.640 rs4666024 chr2:28072979 C/G cg27432699 chr2:27873401 GPN1 -0.46 -6.39 -0.33 5.58e-10 Response to carboplatin and paclitaxel in ovarian cancer (Caspase 3/7 EC50); CRC cis rs1707322 0.662 rs11211160 chr1:46146229 T/A cg03146154 chr1:46216737 IPP 0.65 9.51 0.46 4.29e-19 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs4731207 0.596 rs7806807 chr7:124611300 G/A cg23710748 chr7:124431027 NA -0.39 -6.25 -0.33 1.29e-9 Cutaneous malignant melanoma; CRC cis rs3785574 0.962 rs2665835 chr17:61903258 C/T cg25654072 chr17:61904446 PSMC5;FTSJ3 0.44 6.01 0.31 4.82e-9 Height; CRC cis rs3820068 0.603 rs10492986 chr1:15988702 T/C cg27534772 chr1:16042836 PLEKHM2 0.52 9.74 0.47 7.51e-20 Systolic blood pressure; CRC cis rs6460942 0.591 rs62448729 chr7:12333720 G/C cg20607287 chr7:12443886 VWDE -0.56 -6.15 -0.32 2.21e-9 Coronary artery disease; CRC cis rs2952156 0.684 rs11658786 chr17:37815899 G/A cg20243544 chr17:37824526 PNMT 0.54 8.71 0.43 1.46e-16 Asthma; CRC cis rs7523050 0.643 rs12729998 chr1:109405505 T/C cg08274380 chr1:109419600 GPSM2 0.83 6.52 0.34 2.6e-10 Fat distribution (HIV); CRC cis rs7618915 0.570 rs4687633 chr3:52630548 G/A cg08222913 chr3:52553049 STAB1 -0.34 -6.19 -0.32 1.77e-9 Bipolar disorder; CRC trans rs1814175 0.645 rs4598671 chr11:50003191 C/A cg15704280 chr7:45808275 SEPT13 -0.92 -16.92 -0.68 1.2e-46 Height; CRC cis rs1218582 0.774 rs2335409 chr1:154916106 G/A cg16680214 chr1:154839983 KCNN3 -0.47 -8.88 -0.44 4.51e-17 Prostate cancer; CRC cis rs10876993 0.784 rs1871417 chr12:58018979 C/T cg18357645 chr12:58087776 OS9 -0.5 -6.75 -0.35 6.85e-11 Celiac disease or Rheumatoid arthritis; CRC cis rs897984 0.520 rs12928081 chr16:30885159 T/G cg02466173 chr16:30829666 NA 0.7 9.11 0.45 8.49e-18 Dementia with Lewy bodies; CRC cis rs4665809 1.000 rs4665306 chr2:26319124 C/T cg27170947 chr2:26402098 FAM59B -0.45 -6.06 -0.32 3.68e-9 Gut microbiome composition (summer); CRC cis rs12600856 1 rs12600856 chr17:38163295 T/C cg17344932 chr17:38183730 MED24;SNORD124 -0.45 -6.98 -0.36 1.62e-11 Sum neutrophil eosinophil counts;Sum basophil neutrophil counts;White blood cell count;Granulocyte count;Neutrophil count;Myeloid white cell count; CRC cis rs2952156 0.883 rs2517960 chr17:37846521 T/C cg00129232 chr17:37814104 STARD3 -0.74 -13.23 -0.59 2.59e-32 Asthma; CRC cis rs11628318 0.614 rs11847932 chr14:103185435 T/G cg08075719 chr14:103021372 NA 0.64 7.38 0.38 1.31e-12 Platelet count; CRC cis rs7523050 0.730 rs72984612 chr1:109434826 T/C cg08274380 chr1:109419600 GPSM2 0.89 7.75 0.39 1.18e-13 Fat distribution (HIV); CRC cis rs11997175 0.574 rs4446694 chr8:33654978 A/G cg04338863 chr8:33670619 NA 0.39 6.84 0.35 3.92e-11 Body mass index; CRC cis rs6963495 0.818 rs73190202 chr7:105166510 A/G cg13798780 chr7:105162888 PUS7 0.69 8.2 0.41 5.36e-15 Bipolar disorder (body mass index interaction); CRC cis rs7149337 0.836 rs12588488 chr14:51660217 C/A cg23942311 chr14:51606299 NA 0.75 13.95 0.61 4.46e-35 Cancer; CRC cis rs7666738 0.830 rs13108871 chr4:98803872 T/C cg05340658 chr4:99064831 C4orf37 0.58 8.62 0.43 2.87e-16 Colonoscopy-negative controls vs population controls; CRC cis rs1403694 1.000 rs2304451 chr3:186437661 G/C cg04611788 chr3:186434169 KNG1 -0.45 -6.97 -0.36 1.69e-11 Blood protein levels; CRC cis rs262150 0.659 rs2527236 chr7:158796644 C/T cg04239562 chr7:158767014 NA 0.36 5.61 0.3 4.19e-8 Facial morphology (factor 20); CRC trans rs13086611 1 rs13086611 chr3:49385417 A/T cg21659725 chr3:3221576 CRBN -0.58 -7.88 -0.4 4.87e-14 Educational attainment; CRC cis rs1552244 1.000 rs3826 chr3:10141065 T/G cg08888203 chr3:10149979 C3orf24 0.67 9.77 0.47 6.02e-20 Alzheimer's disease; CRC cis rs28655083 0.529 rs285019 chr16:77099450 G/A cg01753188 chr16:77233325 SYCE1L;MON1B 0.49 6.91 0.36 2.51e-11 Lobe attachment (rater-scored or self-reported); CRC cis rs800160 0.777 rs10765944 chr11:2348194 A/G cg09785033 chr11:2336066 TSPAN32 -0.55 -6.32 -0.33 8.6e-10 Bacteremia; CRC cis rs9287719 0.614 rs12329184 chr2:10722764 T/C cg00105475 chr2:10696890 NA 0.44 7.0 0.36 1.43e-11 Prostate cancer; CRC cis rs514406 0.893 rs512723 chr1:53343880 C/T cg08859206 chr1:53392774 SCP2 0.46 6.99 0.36 1.51e-11 Monocyte count; CRC cis rs427941 0.703 rs201451 chr7:101739550 G/A cg06246474 chr7:101738831 CUX1 0.46 7.23 0.37 3.35e-12 Plasma omega-3 polyunsaturated fatty acid level (eicosapentaenoic acid); CRC trans rs2243480 1.000 rs781149 chr7:65481284 C/T cg10756647 chr7:56101905 PSPH 0.77 8.22 0.41 4.72e-15 Diabetic kidney disease; CRC cis rs9894429 1.000 rs7503679 chr17:79583843 G/C cg18240062 chr17:79603768 NPLOC4 0.56 9.34 0.46 1.54e-18 Eye color traits; CRC cis rs2228479 0.850 rs2302162 chr16:89845287 A/G cg06558623 chr16:89946397 TCF25 1.09 10.23 0.49 1.69e-21 Skin colour saturation; CRC cis rs12913538 0.715 rs955529 chr15:62881864 A/T cg09983546 chr15:62884068 NA -0.47 -6.95 -0.36 1.92e-11 Sleep depth; CRC cis rs2976388 0.566 rs4736373 chr8:143792357 G/C cg15511327 chr8:143859410 LYNX1 -0.42 -6.85 -0.35 3.68e-11 Urinary tract infection frequency; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg08113034 chr14:59655386 DAAM1 0.47 6.0 0.31 5.08e-9 Thyroid stimulating hormone; CRC cis rs1552244 0.572 rs3774208 chr3:10164722 T/G cg08888203 chr3:10149979 C3orf24 0.71 8.57 0.43 4.18e-16 Alzheimer's disease; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg09934056 chr19:8400203 KANK3 0.43 6.22 0.32 1.51e-9 Anxiety disorder; CRC cis rs344364 0.511 rs1742460 chr16:1945441 G/C cg14074117 chr16:1909714 C16orf73 0.49 6.52 0.34 2.59e-10 Glomerular filtration rate in chronic kidney disease; CRC cis rs561341 1.000 rs510264 chr17:30323414 A/G cg23018236 chr17:30244563 NA -0.67 -7.99 -0.4 2.29e-14 Hip circumference adjusted for BMI; CRC cis rs6674176 0.561 rs4660263 chr1:44421433 A/C cg15962314 chr1:44399869 ARTN 0.3 5.84 0.31 1.28e-8 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Cognitive ability; CRC cis rs7584330 0.695 rs7570882 chr2:238435086 G/A cg14458575 chr2:238380390 NA 0.46 8.07 0.41 1.32e-14 Prostate cancer; CRC cis rs736408 0.812 rs746694 chr3:52826620 C/T cg11645453 chr3:52864694 ITIH4 0.49 8.6 0.43 3.23e-16 Bipolar disorder; CRC cis rs9467603 1.000 rs1892250 chr6:25769024 T/C cg08501292 chr6:25962987 TRIM38 -0.96 -8.66 -0.43 2.18e-16 Intelligence (multi-trait analysis); CRC cis rs7122539 0.768 rs7931485 chr11:66578635 G/A cg24851651 chr11:66362959 CCS 0.45 7.9 0.4 4.36e-14 HIV-1 susceptibility; CRC cis rs2243480 1.000 rs6460274 chr7:65628484 T/A cg18252515 chr7:66147081 NA 1.23 14.38 0.62 9.77e-37 Diabetic kidney disease; CRC cis rs7552404 0.731 rs10873787 chr1:76367797 G/A cg10523679 chr1:76189770 ACADM 0.73 8.75 0.43 1.11e-16 Blood metabolite levels;Acylcarnitine levels; CRC cis rs6570726 0.935 rs447247 chr6:145812678 G/T cg05347473 chr6:146136440 FBXO30 0.37 5.89 0.31 9.78e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs7113874 0.589 rs7112153 chr11:8461178 T/C cg02811074 chr11:8615871 STK33 -0.35 -5.89 -0.31 9.34e-9 Body mass index in physically active individuals;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs4555082 1.000 rs7146643 chr14:105757392 A/G cg10792982 chr14:105748885 BRF1 0.39 7.22 0.37 3.71e-12 Mean platelet volume;Platelet distribution width; CRC trans rs875971 0.660 rs2191268 chr7:66110224 C/T cg15879533 chr17:56709523 TEX14 -0.41 -6.62 -0.34 1.44e-10 Aortic root size; CRC trans rs1814175 0.669 rs11040455 chr11:49669829 G/C cg21153622 chr11:89784906 NA -0.43 -7.2 -0.37 4.08e-12 Height; CRC cis rs13191362 1.000 rs13214516 chr6:163121583 A/T cg06582575 chr6:163149167 PACRG;PARK2 0.92 11.66 0.54 1.6e-26 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs780096 0.525 rs13388159 chr2:27648284 A/T cg12648201 chr2:27665141 KRTCAP3 -0.31 -6.1 -0.32 3.05e-9 Total body bone mineral density; CRC cis rs6484504 0.576 rs286649 chr11:31230468 C/T cg14844989 chr11:31128820 NA -0.34 -6.0 -0.31 5.16e-9 Red blood cell count; CRC cis rs453193 0.789 rs2630707 chr2:8447203 A/C cg12167548 chr2:8464763 NA -0.29 -5.86 -0.31 1.09e-8 Granulocyte percentage of myeloid white cells; CRC trans rs2727020 0.729 rs10839268 chr11:49380328 G/A cg15704280 chr7:45808275 SEPT13 -0.89 -16.27 -0.67 4.29e-44 Coronary artery disease; CRC trans rs1814175 0.645 rs10839456 chr11:49964093 C/T cg15704280 chr7:45808275 SEPT13 -0.94 -16.63 -0.68 1.69e-45 Height; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg12868349 chr11:71639594 RNF121;LOC100133315 0.49 6.43 0.33 4.4e-10 Thyroid stimulating hormone; CRC cis rs6968419 0.747 rs2030978 chr7:115874560 C/T cg02561103 chr7:115862891 TES -0.42 -6.28 -0.33 1.09e-9 Intraocular pressure; CRC cis rs12908161 1.000 rs62019469 chr15:85321220 T/C cg11189052 chr15:85197271 WDR73 0.59 8.47 0.42 8.06e-16 Schizophrenia; CRC cis rs7927592 0.913 rs7106010 chr11:68365212 C/T cg16797656 chr11:68205561 LRP5 0.37 5.94 0.31 7.34e-9 Total body bone mineral density; CRC cis rs1005277 0.603 rs1998062 chr10:38457652 G/C cg00409905 chr10:38381863 ZNF37A -0.66 -11.02 -0.52 2.92e-24 Extrinsic epigenetic age acceleration; CRC cis rs2859741 1.000 rs543121 chr1:37497098 T/C cg09363841 chr1:37513479 NA -0.63 -11.73 -0.54 8.94e-27 Forced expiratory volume in 1 second (environmental tobacco smoke interaction); CRC cis rs10464366 0.544 rs34866559 chr7:39166071 G/A cg18850127 chr7:39170497 POU6F2 0.58 7.65 0.39 2.27e-13 IgG glycosylation; CRC cis rs9322193 0.923 rs2880436 chr6:150180259 T/C cg13206674 chr6:150067644 NUP43 0.64 8.98 0.44 2.11e-17 Lung cancer; CRC cis rs12142240 0.731 rs6658556 chr1:46844180 A/C cg00530320 chr1:46809349 NSUN4 0.57 7.54 0.38 4.69e-13 Menopause (age at onset); CRC cis rs911555 0.576 rs8015723 chr14:103895909 A/G cg12935359 chr14:103987150 CKB 0.51 7.84 0.4 6.26e-14 Intelligence (multi-trait analysis); CRC cis rs1451375 0.617 rs9942686 chr7:50596381 G/A cg14593290 chr7:50529359 DDC 0.62 8.04 0.41 1.62e-14 Malaria; CRC cis rs3785574 0.962 rs62077512 chr17:61851435 C/T cg06601766 chr17:61851465 DDX42;CCDC47 0.6 8.54 0.43 5.08e-16 Height; CRC cis rs6504950 0.830 rs12951542 chr17:53041965 T/C cg26251398 chr17:52985966 TOM1L1 0.42 5.62 0.3 4.01e-8 Breast cancer; CRC cis rs4237845 0.715 rs4760340 chr12:58275176 A/T cg00677455 chr12:58241039 CTDSP2 0.45 6.69 0.35 9.84e-11 Intelligence (multi-trait analysis); CRC cis rs10256972 0.591 rs6968988 chr7:1169619 A/G cg18402987 chr7:1209562 NA 0.5 7.56 0.38 4.07e-13 Longevity;Endometriosis; CRC cis rs875971 0.862 rs778724 chr7:65829291 T/C cg18252515 chr7:66147081 NA -0.39 -5.78 -0.3 1.69e-8 Aortic root size; CRC cis rs2976388 0.590 rs7828042 chr8:143819383 A/G cg15511327 chr8:143859410 LYNX1 -0.39 -6.52 -0.34 2.6e-10 Urinary tract infection frequency; CRC cis rs12971120 1.000 rs12971120 chr18:72174023 A/G cg25817165 chr18:72167213 CNDP2 -0.66 -9.37 -0.46 1.21e-18 Refractive error; CRC cis rs1552172 0.887 rs12732381 chr1:145630536 T/A cg11743829 chr1:145714124 CD160 -0.4 -6.06 -0.32 3.69e-9 Breast cancer; CRC cis rs11229555 0.645 rs6591475 chr11:58193551 G/T cg15696309 chr11:58395628 NA 0.83 10.45 0.5 2.98e-22 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; CRC cis rs2204008 0.774 rs8189620 chr12:38241621 A/G cg13010199 chr12:38710504 ALG10B 0.45 5.75 0.3 2.07e-8 Bladder cancer; CRC cis rs7412746 0.611 rs10888391 chr1:150729983 G/A cg18016565 chr1:150552671 MCL1 0.43 5.92 0.31 8.32e-9 Melanoma; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg20996918 chr1:155243486 CLK2 0.45 6.06 0.32 3.62e-9 Thyroid stimulating hormone; CRC cis rs1395 0.744 rs11126935 chr2:27476740 G/T cg23587288 chr2:27483067 SLC30A3 -0.4 -6.74 -0.35 7.29e-11 Blood metabolite levels; CRC cis rs6088590 1.000 rs2295353 chr20:33356511 C/T cg08999081 chr20:33150536 PIGU 0.5 8.44 0.42 1e-15 Coronary artery disease; CRC trans rs1346081 0.786 rs1425645 chr4:68028175 C/T cg17823892 chr15:85525171 PDE8A 0.49 5.99 0.31 5.65e-9 Intelligence (multi-trait analysis); CRC cis rs2050392 0.687 rs608693 chr10:30734971 G/A cg25182066 chr10:30743637 MAP3K8 -0.44 -6.27 -0.33 1.11e-9 Inflammatory bowel disease; CRC cis rs10927875 0.619 rs2102664 chr1:16130169 A/G cg21385522 chr1:16154831 NA -0.75 -11.89 -0.55 2.27e-27 Dilated cardiomyopathy; CRC cis rs868943 0.582 rs9488861 chr6:116502405 A/G cg15226275 chr6:116381976 FRK 0.23 5.83 0.31 1.3e-8 Total cholesterol levels; CRC trans rs1814175 0.817 rs7947526 chr11:49983654 T/C cg03929089 chr4:120376271 NA -0.94 -17.69 -0.7 1.09e-49 Height; CRC cis rs950169 0.881 rs4081123 chr15:84956235 A/G cg17507749 chr15:85114479 UBE2QP1 0.74 10.59 0.5 9.91e-23 Schizophrenia; CRC cis rs9359856 0.517 rs72919948 chr6:90509389 C/T cg13799429 chr6:90582589 CASP8AP2 -0.75 -7.85 -0.4 5.92e-14 Bipolar disorder; CRC trans rs1814175 0.740 rs10839439 chr11:49918240 C/T cg21153622 chr11:89784906 NA -0.37 -6.01 -0.31 4.83e-9 Height; CRC cis rs7208859 0.623 rs76633166 chr17:29113365 C/T cg13385521 chr17:29058706 SUZ12P 0.74 8.44 0.42 9.97e-16 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs7224685 0.501 rs11649992 chr17:4026823 A/C cg09597638 chr17:3907349 NA -0.67 -11.49 -0.53 6.64e-26 Type 2 diabetes; CRC cis rs10504229 0.593 rs17794451 chr8:58019217 C/T cg24829409 chr8:58192753 C8orf71 -0.54 -6.59 -0.34 1.75e-10 Developmental language disorder (linguistic errors); CRC cis rs854765 0.964 rs854764 chr17:18011750 A/G cg04398451 chr17:18023971 MYO15A 0.62 9.25 0.45 2.96e-18 Total body bone mineral density; CRC cis rs11997175 0.740 rs6991071 chr8:33814103 G/A ch.8.33884649F chr8:33765107 NA 0.47 6.83 0.35 4.16e-11 Body mass index; CRC cis rs41005 0.967 rs193928 chr2:8107899 T/C cg03155496 chr2:8117019 LOC339788 0.41 7.29 0.37 2.4e-12 Response to anti-TNF therapy in rheumatoid arthritis; CRC cis rs853679 0.517 rs3757187 chr6:28107654 T/C cg12273811 chr6:28175739 NA 0.73 9.36 0.46 1.34e-18 Depression; CRC cis rs2439831 0.867 rs76542740 chr15:43891512 C/T cg02155558 chr15:43621948 ADAL;LCMT2 0.68 7.74 0.39 1.22e-13 Lung cancer in ever smokers; CRC cis rs743757 1.000 rs2236987 chr3:50504546 C/T cg09545109 chr3:50388910 TUSC4;CYB561D2 -0.4 -5.68 -0.3 3.03e-8 Diastolic blood pressure; CRC cis rs1401999 1.000 rs4148579 chr3:183685249 T/C cg01324343 chr3:183735012 ABCC5 0.79 14.36 0.62 1.22e-36 Anterior chamber depth; CRC cis rs9303280 0.773 rs4795397 chr17:38023745 A/G cg11212589 chr17:38028394 ZPBP2 0.4 7.36 0.38 1.45e-12 Self-reported allergy; CRC trans rs10838798 0.504 rs11039673 chr11:48335156 G/A cg21153622 chr11:89784906 NA -0.5 -8.21 -0.41 5.26e-15 Height; CRC cis rs6570726 0.764 rs9403733 chr6:145912311 A/C cg05347473 chr6:146136440 FBXO30 0.4 5.98 0.31 5.84e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs6964587 0.626 rs6979235 chr7:91511776 T/C cg17063962 chr7:91808500 NA -0.59 -9.41 -0.46 8.55e-19 Breast cancer; CRC cis rs10504229 0.683 rs882429 chr8:58129292 A/G cg21724239 chr8:58056113 NA 0.49 6.81 0.35 4.75e-11 Developmental language disorder (linguistic errors); CRC cis rs10791323 0.604 rs2250025 chr11:133710914 G/A cg15485101 chr11:133734466 NA 0.45 7.7 0.39 1.65e-13 Childhood ear infection; CRC trans rs11039798 0.764 rs2089208 chr11:48899860 C/T cg03929089 chr4:120376271 NA 0.64 6.1 0.32 3.01e-9 Axial length; CRC cis rs7584330 0.518 rs79618460 chr2:238419959 T/C cg08992911 chr2:238395768 MLPH 0.6 5.8 0.3 1.58e-8 Prostate cancer; CRC cis rs172166 0.694 rs1770131 chr6:28086413 C/T cg15845792 chr6:28175446 NA 0.8 11.59 0.54 2.82e-26 Cardiac Troponin-T levels; CRC cis rs10504229 1.000 rs79561699 chr8:58170601 A/G cg22535103 chr8:58192502 C8orf71 -0.79 -12.08 -0.55 4.59e-28 Developmental language disorder (linguistic errors); CRC cis rs875971 0.545 rs12670811 chr7:65823019 C/A cg11764359 chr7:65958608 NA 0.44 5.6 0.3 4.52e-8 Aortic root size; CRC cis rs7811142 0.775 rs6946768 chr7:99954393 G/A cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.94 11.97 0.55 1.17e-27 Platelet count; CRC cis rs929596 0.564 rs2602373 chr2:234561953 T/C cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.44 -5.83 -0.31 1.3e-8 Total bilirubin levels in HIV-1 infection; CRC cis rs10982256 0.870 rs998547 chr9:117275012 G/A cg13636371 chr9:117264095 DFNB31 0.37 7.2 0.37 4.2e-12 Bipolar disorder; CRC cis rs13082711 0.596 rs479404 chr3:27363064 T/C cg02860705 chr3:27208620 NA 0.5 7.29 0.37 2.36e-12 Systolic blood pressure;Diastolic blood pressure;Blood pressure; CRC cis rs2495707 0.647 rs1541266 chr10:102421292 C/T cg22689833 chr10:102415991 NA -0.34 -6.57 -0.34 2.01e-10 Body mass index; CRC cis rs9467711 0.516 rs555460 chr6:25870655 C/T cg08501292 chr6:25962987 TRIM38 0.58 6.55 0.34 2.18e-10 Autism spectrum disorder or schizophrenia; CRC cis rs2014572 0.967 rs10421632 chr19:57764770 G/A cg24459738 chr19:57751996 ZNF805 -0.56 -8.9 -0.44 3.82e-17 Hyperactive-impulsive symptoms; CRC cis rs2243480 1.000 rs781149 chr7:65481284 C/T cg12463550 chr7:65579703 CRCP 0.7 6.44 0.33 4.33e-10 Diabetic kidney disease; CRC cis rs7552404 0.765 rs211717 chr1:76106969 G/A cg10523679 chr1:76189770 ACADM -0.83 -11.3 -0.53 3.14e-25 Blood metabolite levels;Acylcarnitine levels; CRC cis rs6662572 0.737 rs9429091 chr1:46513088 C/T cg08644498 chr1:46502608 NA 0.46 7.34 0.38 1.65e-12 Blood protein levels; CRC cis rs1799949 1.000 rs8176120 chr17:41261233 C/T cg01879757 chr17:41196368 BRCA1 -0.43 -6.58 -0.34 1.82e-10 Menopause (age at onset); CRC cis rs9768139 0.733 rs71545585 chr7:158118672 G/A cg25566285 chr7:158114605 PTPRN2 0.47 7.52 0.38 5.39e-13 Calcium levels; CRC cis rs1552244 1.000 rs9879080 chr3:10084224 C/T cg13047869 chr3:10149882 C3orf24 0.53 7.44 0.38 8.73e-13 Alzheimer's disease; CRC trans rs1814175 0.541 rs12287397 chr11:49819799 G/A cg03929089 chr4:120376271 NA -0.94 -17.7 -0.7 1.01e-49 Height; CRC trans rs16846053 0.681 rs62187563 chr2:162354653 G/A cg27113153 chr11:123612418 ZNF202 -0.72 -6.16 -0.32 2.13e-9 Blood osmolality (transformed sodium); CRC cis rs116095464 0.558 rs73031482 chr5:227594 G/A cg22496380 chr5:211416 CCDC127 -0.81 -9.73 -0.47 7.64e-20 Breast cancer; CRC cis rs7811142 1.000 rs7803454 chr7:99991548 C/T cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.98 12.25 0.56 1.11e-28 Platelet count; CRC cis rs853679 0.517 rs1904840 chr6:28108232 C/T cg25164649 chr6:28176230 NA 0.78 9.66 0.47 1.33e-19 Depression; CRC cis rs2739330 0.627 rs9608219 chr22:24274119 G/C cg10819733 chr22:24237672 NA -0.36 -6.08 -0.32 3.35e-9 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs1971762 0.527 rs11170590 chr12:53938913 G/A cg06632207 chr12:54070931 ATP5G2 0.45 7.64 0.39 2.44e-13 Height; CRC cis rs9768139 0.733 rs13309408 chr7:158122261 C/T cg24154853 chr7:158122151 PTPRN2 0.66 10.88 0.51 9.33e-24 Calcium levels; CRC cis rs1580019 0.534 rs13237495 chr7:32560687 A/G cg06627557 chr7:32535165 LSM5;AVL9 0.91 16.9 0.68 1.4e-46 Cognitive ability; CRC cis rs1401999 0.714 rs1533683 chr3:183635488 C/T cg20387954 chr3:183756860 HTR3D 0.35 5.79 0.3 1.63e-8 Anterior chamber depth; CRC cis rs10493773 0.609 rs12097932 chr1:86182216 A/G cg17807903 chr1:86174739 ZNHIT6 -0.64 -17.43 -0.69 1.16e-48 Urate levels in overweight individuals; CRC cis rs9914988 0.887 rs12948575 chr17:27130520 G/A cg16670446 chr17:27188758 MIR451;MIR144 0.55 8.52 0.43 5.75e-16 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs3804749 0.966 rs3792376 chr3:122844951 T/G cg26084141 chr3:122786895 PDIA5 0.23 6.08 0.32 3.42e-9 Plateletcrit;Mean platelet volume;Platelet count;Platelet distribution width; CRC cis rs11148252 0.774 rs9536066 chr13:52983981 A/G cg00495681 chr13:53174319 NA 0.61 9.5 0.46 4.35e-19 Lewy body disease; CRC cis rs10540 1.000 rs79440439 chr11:478147 A/C cg08200582 chr11:442649 ANO9 -0.67 -6.38 -0.33 5.84e-10 Body mass index; CRC cis rs7584330 0.554 rs56881028 chr2:238446678 C/G cg14458575 chr2:238380390 NA 0.44 6.11 0.32 2.77e-9 Prostate cancer; CRC cis rs2404602 0.536 rs1587381 chr15:76769620 G/A cg22467129 chr15:76604101 ETFA -0.45 -7.78 -0.39 9.43e-14 Blood metabolite levels; CRC cis rs7618915 0.571 rs2251219 chr3:52584787 C/T cg18099408 chr3:52552593 STAB1 0.43 7.03 0.36 1.19e-11 Bipolar disorder; CRC trans rs11250097 0.549 rs11784897 chr8:11310442 G/A cg06636001 chr8:8085503 FLJ10661 -0.47 -6.63 -0.34 1.39e-10 Neuroticism; CRC cis rs9905704 0.874 rs2643126 chr17:56737765 A/G cg12560992 chr17:57184187 TRIM37 0.56 7.73 0.39 1.29e-13 Testicular germ cell tumor; CRC cis rs7811142 1.000 rs73405353 chr7:100091215 G/A cg00814883 chr7:100076585 TSC22D4 -0.79 -9.88 -0.48 2.44e-20 Platelet count; CRC cis rs6951245 1.000 rs11766526 chr7:1101433 G/A cg22907277 chr7:1156413 C7orf50 0.73 7.68 0.39 1.78e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC trans rs61931739 0.500 rs7963282 chr12:34535255 A/C cg26384229 chr12:38710491 ALG10B 0.59 8.77 0.44 9.64e-17 Morning vs. evening chronotype; CRC cis rs59918340 0.728 rs2304279 chr8:142229891 A/G cg23750338 chr8:142222470 SLC45A4 0.62 11.6 0.54 2.53e-26 Immature fraction of reticulocytes; CRC cis rs11971779 0.715 rs6954219 chr7:139065110 G/C cg07862535 chr7:139043722 LUC7L2 0.57 7.35 0.38 1.61e-12 Diisocyanate-induced asthma; CRC cis rs796364 0.806 rs34582889 chr2:201010527 A/G cg23649088 chr2:200775458 C2orf69 -0.58 -5.91 -0.31 8.54e-9 Schizophrenia; CRC cis rs9926296 0.605 rs7205053 chr16:89856763 G/C cg21285383 chr16:89894308 SPIRE2 0.34 5.69 0.3 2.82e-8 Vitiligo; CRC cis rs9303542 0.571 rs2202895 chr17:46584657 T/C cg04904318 chr17:46607828 HOXB1 0.45 5.95 0.31 6.86e-9 Ovarian cancer;Epithelial ovarian cancer; CRC trans rs1005277 0.528 rs2057228 chr10:38515766 T/C cg23533926 chr12:111358616 MYL2 -0.56 -8.67 -0.43 2e-16 Extrinsic epigenetic age acceleration; CRC cis rs2739330 0.731 rs4822450 chr22:24242887 C/T cg16132339 chr22:24313637 DDTL;DDT 0.58 9.24 0.45 3.17e-18 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs853679 0.517 rs3757187 chr6:28107654 T/C cg02683197 chr6:28174875 NA 0.85 10.52 0.5 1.71e-22 Depression; CRC trans rs3733585 0.660 rs13122290 chr4:9933832 A/G cg26043149 chr18:55253948 FECH -0.52 -7.78 -0.39 9.57e-14 Cleft plate (environmental tobacco smoke interaction); CRC cis rs1552244 1.000 rs56270432 chr3:10087517 G/C cg10729496 chr3:10149963 C3orf24 0.5 6.74 0.35 7.23e-11 Alzheimer's disease; CRC cis rs4862750 0.872 rs13110072 chr4:187878524 A/G cg03452623 chr4:187889614 NA -0.9 -21.04 -0.76 7.13e-63 Lobe attachment (rater-scored or self-reported); CRC cis rs7937682 0.855 rs490897 chr11:111487914 A/G cg09085632 chr11:111637200 PPP2R1B -0.96 -18.54 -0.71 4.92e-53 Primary sclerosing cholangitis; CRC cis rs11764590 0.724 rs55669426 chr7:2090129 G/C cg14004847 chr7:1930337 MAD1L1 -0.45 -6.12 -0.32 2.72e-9 Neuroticism; CRC cis rs12142240 0.698 rs1057534 chr1:46815880 A/C cg00530320 chr1:46809349 NSUN4 0.57 7.75 0.39 1.19e-13 Menopause (age at onset); CRC cis rs6539288 0.641 rs12318060 chr12:107340612 T/C cg16260113 chr12:107380972 MTERFD3 -0.4 -5.67 -0.3 3.11e-8 Total body bone mineral density; CRC cis rs13315871 0.929 rs35004361 chr3:58313394 T/C cg20936604 chr3:58311152 NA -0.74 -7.75 -0.39 1.17e-13 Cholesterol, total; CRC cis rs7945705 0.967 rs7943377 chr11:8848700 C/T cg21881798 chr11:8931708 C11orf17;ST5 0.54 7.9 0.4 4.11e-14 Hemoglobin concentration; CRC cis rs9549367 0.789 rs71446682 chr13:113894908 A/G cg18105134 chr13:113819100 PROZ -0.72 -10.54 -0.5 1.41e-22 Platelet distribution width; CRC cis rs916888 0.647 rs199523 chr17:44848517 C/A cg15921436 chr17:44337874 NA -0.51 -6.54 -0.34 2.39e-10 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs9549367 0.713 rs2476328 chr13:113829350 C/T cg24300038 chr13:113819356 PROZ 0.49 6.45 0.34 4e-10 Platelet distribution width; CRC cis rs9296092 0.538 rs9461887 chr6:33526827 C/T cg13560919 chr6:33536144 NA -0.42 -5.69 -0.3 2.78e-8 Age at smoking initiation in chronic obstructive pulmonary disease; CRC cis rs7851660 0.527 rs7870795 chr9:100574120 A/G cg13688889 chr9:100608707 NA -0.4 -5.73 -0.3 2.32e-8 Strep throat; CRC cis rs2354432 0.607 rs7537483 chr1:146709877 C/G cg25205988 chr1:146714368 CHD1L 1.14 8.9 0.44 3.71e-17 Mitochondrial DNA levels; CRC cis rs5750830 0.649 rs5750822 chr22:39826788 C/T cg24399712 chr22:39784796 NA -0.53 -11.09 -0.52 1.75e-24 Intelligence (multi-trait analysis); CRC cis rs7811142 0.830 rs73401443 chr7:99977582 T/G cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.88 11.91 0.55 1.9e-27 Platelet count; CRC trans rs11039798 0.920 rs8186465 chr11:48796771 T/C cg03929089 chr4:120376271 NA 0.63 6.01 0.31 4.92e-9 Axial length; CRC cis rs7487075 1.000 rs12814341 chr12:46823272 T/C cg22049899 chr12:47219821 SLC38A4 0.31 6.02 0.32 4.63e-9 Itch intensity from mosquito bite; CRC cis rs727505 0.954 rs66871687 chr7:124670475 A/G cg23710748 chr7:124431027 NA -0.79 -13.59 -0.6 1.08e-33 Lewy body disease; CRC cis rs4722166 0.695 rs35779989 chr7:22800314 A/C cg05472934 chr7:22766657 IL6 0.65 10.65 0.51 5.77e-23 Lung cancer; CRC cis rs10504229 0.683 rs35889486 chr8:58117749 T/A cg04204079 chr8:58130323 NA -0.45 -5.78 -0.3 1.71e-8 Developmental language disorder (linguistic errors); CRC cis rs1008375 0.966 rs11733730 chr4:17625209 G/C cg16339924 chr4:17578868 LAP3 0.55 7.24 0.37 3.11e-12 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs10504229 0.724 rs73603871 chr8:58107612 A/G cg05313129 chr8:58192883 C8orf71 -0.43 -5.87 -0.31 1.09e-8 Developmental language disorder (linguistic errors); CRC cis rs9467711 0.606 rs12174602 chr6:26372827 C/T cg16898833 chr6:26189333 HIST1H4D 0.74 6.35 0.33 7.32e-10 Autism spectrum disorder or schizophrenia; CRC cis rs7827545 0.644 rs7386524 chr8:135534005 T/C cg09855544 chr8:135498122 ZFAT -0.43 -5.61 -0.3 4.2e-8 Hypertension (SNP x SNP interaction); CRC cis rs701145 0.556 rs355771 chr3:154039385 G/C cg16511985 chr3:153974050 SGEF 0.45 5.9 0.31 9.05e-9 Coronary artery disease; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg13556659 chr11:94276960 FUT4 -0.43 -6.37 -0.33 6.33e-10 Myopia (pathological); CRC cis rs6952808 0.575 rs2056479 chr7:1954273 G/A cg04267008 chr7:1944627 MAD1L1 -0.63 -9.72 -0.47 8.4e-20 Bipolar disorder and schizophrenia; CRC cis rs2992756 1.000 rs2992756 chr1:18807339 T/C cg13507429 chr1:18807550 KLHDC7A -0.36 -6.48 -0.34 3.28e-10 Breast cancer; CRC cis rs11122272 0.668 rs2749712 chr1:231537751 T/A cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.59 -8.85 -0.44 5.38e-17 Hemoglobin concentration; CRC cis rs929596 0.531 rs2741021 chr2:234511883 A/G cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 0.45 5.92 0.31 8.09e-9 Total bilirubin levels in HIV-1 infection; CRC cis rs863345 0.565 rs6679056 chr1:158450314 A/G cg12129480 chr1:158549410 OR10X1 -0.29 -6.17 -0.32 2.03e-9 Pneumococcal bacteremia; CRC cis rs9733 0.596 rs6587518 chr1:150661787 T/C cg18016565 chr1:150552671 MCL1 0.46 6.75 0.35 6.69e-11 Tonsillectomy; CRC cis rs7613875 0.641 rs6793528 chr3:50100188 C/A cg24308560 chr3:49941425 MST1R 0.44 6.9 0.36 2.74e-11 Body mass index; CRC cis rs834811 0.563 rs2033093 chr7:135874334 T/C cg01726295 chr7:135938950 NA 0.33 5.63 0.3 3.85e-8 Post-traumatic stress disorder; CRC cis rs10946940 0.632 rs9366698 chr6:27672035 C/G cg03623178 chr6:28175578 NA 0.55 6.74 0.35 6.97e-11 Systemic lupus erythematosus; CRC cis rs394563 0.775 rs448420 chr6:149785802 T/C cg07828024 chr6:149772892 ZC3H12D -0.53 -9.34 -0.46 1.44e-18 Dupuytren's disease; CRC cis rs2153535 0.580 rs1319169 chr6:8464456 G/A cg21535247 chr6:8435926 SLC35B3 0.5 7.53 0.38 4.89e-13 Motion sickness; CRC cis rs17253792 0.822 rs80321745 chr14:56162947 T/A cg01858014 chr14:56050164 KTN1 -0.88 -7.11 -0.36 7.38e-12 Putamen volume; CRC cis rs7255436 1.000 rs7255436 chr19:8433196 C/A cg10174797 chr19:8464628 RAB11B 0.46 7.91 0.4 3.93e-14 HDL cholesterol; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg13587582 chr20:61847585 YTHDF1 0.46 6.62 0.34 1.47e-10 Anxiety disorder; CRC cis rs10504229 0.906 rs73607869 chr8:58172665 G/T cg05313129 chr8:58192883 C8orf71 -0.47 -6.99 -0.36 1.49e-11 Developmental language disorder (linguistic errors); CRC cis rs3764400 0.567 rs8071199 chr17:46195335 A/T cg10706073 chr17:46328419 SKAP1 0.57 6.12 0.32 2.59e-9 Body mass index; CRC cis rs728616 0.510 rs34817075 chr10:81749740 A/G cg05935833 chr10:81318306 SFTPA2 -0.53 -6.97 -0.36 1.72e-11 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs7833986 0.534 rs2667972 chr8:56906661 C/T cg23139584 chr8:56987506 RPS20;SNORD54 0.79 11.41 0.53 1.23e-25 Height; CRC cis rs6912958 0.754 rs2268994 chr6:88185386 A/T cg08069147 chr6:88032118 GJB7;C6orf162 -0.55 -8.15 -0.41 7.72e-15 Monocyte percentage of white cells; CRC cis rs8014204 0.804 rs2287403 chr14:75259140 C/T cg03030879 chr14:75389066 RPS6KL1 -0.49 -7.83 -0.4 6.72e-14 Caffeine consumption; CRC cis rs79349575 0.783 rs11079844 chr17:47028334 G/A cg22482690 chr17:47019901 SNF8 0.5 8.26 0.41 3.58e-15 Type 2 diabetes; CRC trans rs9858542 0.953 rs9878943 chr3:49434654 G/A cg21665057 chr3:196295764 WDR53;FBXO45 -0.64 -8.73 -0.43 1.3e-16 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs561341 0.556 rs542244 chr17:30307242 T/C cg19193384 chr17:30244184 NA -0.65 -7.49 -0.38 6.27e-13 Hip circumference adjusted for BMI; CRC trans rs6703335 0.870 rs10803142 chr1:243598234 A/G cg02657892 chr1:62190594 TM2D1 0.44 6.06 0.32 3.66e-9 Schizophrenia;Schizophrenia, schizoaffective disorder or bipolar disorder; CRC cis rs9287719 0.625 rs12473787 chr2:10717194 G/C cg00105475 chr2:10696890 NA 0.45 7.08 0.36 8.74e-12 Prostate cancer; CRC trans rs8123881 0.733 rs7268466 chr20:15810676 C/T cg27555944 chr3:49056208 DALRD3 0.6 6.66 0.34 1.15e-10 Body mass index; CRC cis rs4290604 0.667 rs62183331 chr2:237952212 T/C cg23555395 chr2:238036564 NA 0.65 6.42 0.33 4.89e-10 Asthma; CRC trans rs9291683 0.595 rs35250962 chr4:10048271 C/T cg26043149 chr18:55253948 FECH 0.54 8.44 0.42 9.9e-16 Bone mineral density; CRC trans rs916888 0.531 rs183211 chr17:44788310 G/A cg01341218 chr17:43662625 NA 0.64 7.95 0.4 2.94e-14 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg19741408 chr1:90460434 ZNF326;LOC492303 0.48 6.91 0.36 2.58e-11 Response to antipsychotic treatment; CRC cis rs7762018 0.607 rs79728466 chr6:170046405 T/C cg19338460 chr6:170058176 WDR27 -1.25 -10.26 -0.49 1.27e-21 Thiazide-induced adverse metabolic effects in hypertensive patients; CRC cis rs7923609 1.000 rs4379723 chr10:64963449 T/C cg08743896 chr10:65200160 JMJD1C -0.39 -5.68 -0.3 2.93e-8 Educational attainment;Liver enzyme levels (alkaline phosphatase); CRC cis rs877282 0.945 rs11253390 chr10:788678 A/G cg17470449 chr10:769945 NA 0.69 9.03 0.45 1.51e-17 Uric acid levels; CRC cis rs8105895 0.733 rs10423457 chr19:22279267 G/C cg02657401 chr19:22469223 NA -0.35 -5.67 -0.3 3.06e-8 Body mass index (change over time); CRC cis rs4731207 0.596 rs1481331 chr7:124577325 C/G cg23710748 chr7:124431027 NA -0.39 -6.12 -0.32 2.67e-9 Cutaneous malignant melanoma; CRC cis rs2346177 0.875 rs1447565 chr2:46643682 T/A cg26688816 chr2:46740690 ATP6V1E2 -0.49 -7.99 -0.4 2.32e-14 HDL cholesterol; CRC cis rs79057730 0.599 rs35928068 chr7:805363 G/C cg05729249 chr7:766119 PRKAR1B;HEATR2 0.71 7.23 0.37 3.48e-12 Initial pursuit acceleration; CRC cis rs76878669 0.538 rs1785633 chr11:66107527 C/A cg18002602 chr11:66138449 SLC29A2 0.27 5.82 0.31 1.38e-8 Educational attainment (years of education); CRC cis rs34375054 0.624 rs73233307 chr12:125675873 G/C cg20959480 chr12:125599568 AACS 0.39 5.8 0.3 1.59e-8 Post bronchodilator FEV1/FVC ratio; CRC cis rs752010 0.841 rs6661784 chr1:42080312 A/T cg06885757 chr1:42089581 HIVEP3 0.35 6.35 0.33 6.99e-10 Lupus nephritis in systemic lupus erythematosus; CRC cis rs7178572 1.000 rs8024485 chr15:77718368 C/A cg22256960 chr15:77711686 NA -0.69 -10.65 -0.51 5.92e-23 Type 2 diabetes; CRC cis rs11098499 0.697 rs4560394 chr4:120313435 T/G cg24375607 chr4:120327624 NA 0.49 7.53 0.38 5.03e-13 Corneal astigmatism; CRC cis rs72781680 0.821 rs55948613 chr2:24094787 A/G cg08917208 chr2:24149416 ATAD2B 0.55 6.65 0.34 1.25e-10 Lymphocyte counts; CRC cis rs1799949 0.965 rs11654051 chr17:41419656 C/T cg25072359 chr17:41440525 NA 0.45 6.61 0.34 1.53e-10 Menopause (age at onset); CRC cis rs10479542 0.784 rs7702303 chr5:178986436 G/A cg14820908 chr5:178986412 RUFY1 0.38 6.54 0.34 2.32e-10 Lung cancer; CRC trans rs8058130 0.566 rs9926510 chr16:64327067 A/C cg10373645 chr2:74007265 DUSP11 0.38 6.01 0.31 5e-9 Schizophrenia; CRC cis rs965469 1.000 rs2281503 chr20:3263636 G/A cg25506879 chr20:3388711 C20orf194 -0.38 -5.63 -0.3 3.77e-8 IFN-related cytopenia; CRC trans rs2892463 0.504 rs4769777 chr13:30415200 A/G cg13931752 chr15:40660718 DISP2 -0.4 -6.19 -0.32 1.81e-9 Non-word repetition; CRC cis rs7659604 1.000 rs72678650 chr4:122666000 A/G cg20573242 chr4:122745356 CCNA2 0.43 6.47 0.34 3.46e-10 Type 2 diabetes; CRC cis rs9463078 0.715 rs7768521 chr6:45060938 C/G cg25276700 chr6:44698697 NA -0.25 -6.05 -0.32 4e-9 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; CRC cis rs7202877 0.706 rs8054586 chr16:75410705 G/C cg03315344 chr16:75512273 CHST6 0.49 5.7 0.3 2.71e-8 Type 2 diabetes;Type 1 diabetes; CRC cis rs7224737 1.000 rs9903204 chr17:40288062 G/A cg00647820 chr17:40259828 DHX58 -0.46 -6.56 -0.34 2.12e-10 Fibrinogen levels; CRC cis rs10504229 1.000 rs72650900 chr8:58185675 T/A cg02725872 chr8:58115012 NA -0.38 -6.43 -0.33 4.44e-10 Developmental language disorder (linguistic errors); CRC cis rs1799949 0.965 rs8176193 chr17:41231516 C/T cg25072359 chr17:41440525 NA 0.47 7.02 0.36 1.26e-11 Menopause (age at onset); CRC cis rs4757319 0.515 rs7126103 chr11:15337892 T/C cg03245590 chr11:15329459 NA 0.53 9.37 0.46 1.17e-18 Breast cancer; CRC cis rs11622475 1.000 rs12889168 chr14:104481957 A/T cg12183467 chr14:104352244 NA -0.47 -6.42 -0.33 4.79e-10 Bipolar disorder; CRC cis rs758324 0.947 rs60847707 chr5:131252554 C/T cg25547332 chr5:131281432 NA -0.38 -5.62 -0.3 4.04e-8 Alzheimer's disease in APOE e4- carriers; CRC cis rs9583531 0.760 rs9521916 chr13:111385509 A/G cg24331049 chr13:111365604 ING1 -0.49 -5.86 -0.31 1.15e-8 Coronary artery disease; CRC cis rs6546324 0.539 rs4671192 chr2:67841855 A/G cg15745817 chr2:67799979 NA -0.56 -9.54 -0.47 3.44e-19 Endometriosis; CRC cis rs13082711 0.911 rs34981505 chr3:27437322 A/T cg02860705 chr3:27208620 NA 0.6 8.72 0.43 1.44e-16 Systolic blood pressure;Diastolic blood pressure;Blood pressure; CRC cis rs9491140 0.539 rs11755888 chr6:124693042 A/G cg22366943 chr6:124882293 NKAIN2 0.56 8.01 0.4 2.05e-14 Neuroticism; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg08831002 chr7:20826153 SP8 0.41 6.98 0.36 1.6e-11 Liver disease severity in Alagille syndrome; CRC cis rs7191700 0.509 rs416603 chr16:11364079 A/T cg00044050 chr16:11439710 C16orf75 -0.47 -6.58 -0.34 1.87e-10 Multiple sclerosis; CRC trans rs747782 0.528 rs7937670 chr11:48313216 C/T cg03929089 chr4:120376271 NA 0.68 6.72 0.35 8.24e-11 Intraocular pressure; CRC cis rs769267 0.895 rs2916069 chr19:19520358 A/G cg01262667 chr19:19385393 TM6SF2 0.37 6.2 0.32 1.7e-9 Tonsillectomy; CRC cis rs9649213 0.593 rs13246725 chr7:97914898 C/G cg21770322 chr7:97807741 LMTK2 0.54 9.03 0.45 1.52e-17 Prostate cancer (SNP x SNP interaction); CRC trans rs13046373 0.905 rs4816372 chr21:32077414 A/T cg16746620 chr16:89178589 ACSF3 -0.41 -6.3 -0.33 9.75e-10 HDL cholesterol; CRC cis rs1267303 0.637 rs1745371 chr1:46985192 C/T cg08533674 chr1:46993347 NA -0.63 -8.25 -0.41 3.82e-15 Monobrow; CRC trans rs800082 0.501 rs10935507 chr3:144214631 A/T cg24215973 chr2:240111563 HDAC4 0.55 8.34 0.42 2.03e-15 Smoking behavior; CRC cis rs3008870 1.000 rs3008873 chr1:67425770 G/A cg08660285 chr1:67390436 MIER1;WDR78 1.02 15.1 0.64 1.6e-39 Lymphocyte percentage of white cells; CRC cis rs1577917 0.959 rs12201739 chr6:86720739 A/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.53 -6.64 -0.34 1.32e-10 Response to antipsychotic treatment; CRC cis rs11764590 0.543 rs55893771 chr7:2096255 C/T cg25834613 chr7:1915315 MAD1L1 -0.44 -6.23 -0.32 1.46e-9 Neuroticism; CRC cis rs6790105 1 rs6790105 chr3:49393409 C/T cg07690219 chr3:49449608 TCTA;RHOA -0.52 -6.11 -0.32 2.82e-9 Childhood ear infection; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg09019002 chr7:102715232 ARMC10;FBXL13 0.39 5.96 0.31 6.48e-9 Liver disease severity in Alagille syndrome; CRC cis rs10504229 0.683 rs55637580 chr8:58135419 C/T cg04204079 chr8:58130323 NA -0.45 -5.78 -0.3 1.71e-8 Developmental language disorder (linguistic errors); CRC cis rs681343 1.000 rs679574 chr19:49206108 C/G cg21064579 chr19:49206444 FUT2 0.51 9.18 0.45 5.07e-18 Lung adenocarcinoma;Primary sclerosing cholangitis;Childhood ear infection; CRC cis rs916888 0.738 rs199515 chr17:44856641 C/G cg15921436 chr17:44337874 NA -0.65 -7.51 -0.38 5.48e-13 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs7772486 0.902 rs1125462 chr6:146417832 A/G cg23711669 chr6:146136114 FBXO30 0.61 10.41 0.5 4e-22 Lobe attachment (rater-scored or self-reported); CRC cis rs2303745 0.544 rs12710308 chr19:17395879 T/A cg15110403 chr19:17392923 ANKLE1 -0.36 -6.01 -0.31 4.81e-9 Systemic lupus erythematosus; CRC cis rs910316 0.789 rs12894419 chr14:75471802 C/T cg11812906 chr14:75593930 NEK9 0.57 8.64 0.43 2.56e-16 Height; CRC cis rs1865760 1.000 rs2071298 chr6:25914901 G/A cg16482183 chr6:26056742 HIST1H1C 0.55 7.96 0.4 2.84e-14 Height; CRC cis rs11098499 0.954 rs9685777 chr4:120365965 C/A cg09307838 chr4:120376055 NA 0.72 11.14 0.52 1.1e-24 Corneal astigmatism; CRC cis rs9399135 0.967 rs9399129 chr6:135285148 C/A cg24558204 chr6:135376177 HBS1L 0.49 7.53 0.38 5.09e-13 Red blood cell count; CRC cis rs644799 0.601 rs7902 chr11:95565288 A/G cg25622487 chr11:95524042 FAM76B;CEP57 0.69 10.92 0.52 6.76e-24 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs546131 0.820 rs744841 chr11:34857667 G/A cg24088639 chr11:34937564 PDHX;APIP -0.43 -5.88 -0.31 1.02e-8 Lung disease severity in cystic fibrosis; CRC trans rs1005277 0.579 rs1548255 chr10:38417193 T/C cg17830980 chr10:43048298 ZNF37B -0.59 -9.83 -0.48 3.65e-20 Extrinsic epigenetic age acceleration; CRC cis rs1215050 0.765 rs687795 chr4:98754912 C/G cg05340658 chr4:99064831 C4orf37 0.47 6.88 0.35 3.09e-11 Waist-to-hip ratio adjusted for body mass index; CRC cis rs6499255 0.857 rs11643926 chr16:69807282 A/G cg15192750 chr16:69999425 NA 0.55 7.1 0.36 7.76e-12 IgE levels; CRC cis rs10256972 0.641 rs12702017 chr7:1129413 C/T cg23708337 chr7:1209742 NA 0.43 6.47 0.34 3.46e-10 Longevity;Endometriosis; CRC cis rs4073582 0.595 rs801739 chr11:65922589 A/G cg14036092 chr11:66035641 RAB1B 0.5 8.02 0.4 1.85e-14 Gout; CRC cis rs950776 0.518 rs11632604 chr15:78821914 T/C cg06917634 chr15:78832804 PSMA4 0.66 10.42 0.5 3.55e-22 Sudden cardiac arrest; CRC trans rs13046373 0.905 rs4816372 chr21:32077414 A/T cg08057103 chr13:110438916 IRS2 -0.38 -5.96 -0.31 6.56e-9 HDL cholesterol; CRC cis rs12325245 0.536 rs34737210 chr16:58549262 T/C cg01472538 chr16:58549086 SETD6 1.2 7.61 0.39 2.9e-13 Schizophrenia; CRC cis rs4478858 0.735 rs3806255 chr1:31791578 A/G cg00250761 chr1:31883323 NA -0.44 -8.36 -0.42 1.75e-15 Alcohol dependence; CRC cis rs769267 0.895 rs1858999 chr19:19497669 C/G cg01262667 chr19:19385393 TM6SF2 -0.36 -5.9 -0.31 9.11e-9 Tonsillectomy; CRC cis rs3741151 1.000 rs76570090 chr11:73066321 A/T cg17517138 chr11:73019481 ARHGEF17 1.12 9.65 0.47 1.47e-19 GIP levels in response to oral glucose tolerance test (120 minutes); CRC cis rs2842126 0.518 rs1865749 chr10:52013434 A/C cg13488930 chr10:51784648 NA 0.44 5.94 0.31 7.41e-9 Blood protein levels; CRC cis rs9467711 0.538 rs9467626 chr6:25873746 C/A cg16898833 chr6:26189333 HIST1H4D 0.8 6.7 0.35 8.78e-11 Autism spectrum disorder or schizophrenia; CRC cis rs7312933 0.558 rs11181403 chr12:42682902 G/A cg11827402 chr12:42719852 PPHLN1;ZCRB1 0.62 8.56 0.43 4.24e-16 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CRC cis rs7224685 0.501 rs781825 chr17:3966064 A/G cg09695851 chr17:3907499 NA 0.76 14.24 0.62 3.62e-36 Type 2 diabetes; CRC cis rs17125944 0.505 rs118053951 chr14:53259829 G/A cg00686598 chr14:53173677 PSMC6 1.2 11.07 0.52 1.95e-24 Alzheimer's disease (late onset); CRC cis rs875971 0.825 rs66981195 chr7:66079035 C/A cg12463550 chr7:65579703 CRCP -0.47 -6.38 -0.33 5.89e-10 Aortic root size; CRC cis rs4930103 0.935 rs2839698 chr11:2018853 G/A cg06197492 chr11:2016605 H19 0.41 6.4 0.33 5.44e-10 DNA methylation (parent-of-origin);DNA methylation (variation); CRC cis rs7923609 0.967 rs7909269 chr10:65177766 G/A cg08743896 chr10:65200160 JMJD1C -0.42 -6.06 -0.32 3.74e-9 Educational attainment;Liver enzyme levels (alkaline phosphatase); CRC cis rs7539624 0.588 rs6669046 chr1:223906309 T/C cg10100437 chr1:223903862 CAPN2 0.4 5.8 0.3 1.54e-8 Schizophrenia; CRC cis rs6951245 0.872 rs75493422 chr7:1072890 C/T cg21664854 chr7:1097933 C7orf50;GPR146 0.79 8.88 0.44 4.45e-17 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs7267979 0.816 rs404775 chr20:25481117 A/G cg24626310 chr20:25276739 ABHD12;PYGB 0.33 5.84 0.31 1.27e-8 Liver enzyme levels (alkaline phosphatase); CRC cis rs1799949 0.965 rs8176140 chr17:41251646 T/A cg23758822 chr17:41437982 NA 0.8 13.4 0.59 5.54e-33 Menopause (age at onset); CRC cis rs853679 0.517 rs4713145 chr6:28106827 T/C cg21251018 chr6:28226885 NKAPL 0.48 6.33 0.33 7.86e-10 Depression; CRC cis rs11190604 1.000 rs9419897 chr10:102246125 T/C cg07080220 chr10:102295463 HIF1AN 0.47 5.99 0.31 5.47e-9 Palmitoleic acid (16:1n-7) levels; CRC cis rs2380220 0.808 rs2613548 chr6:95910559 C/T cg04719120 chr6:96025338 MANEA -0.53 -5.88 -0.31 9.93e-9 Behavioural disinhibition (generation interaction); CRC cis rs9910055 0.762 rs2526021 chr17:42213347 G/A cg16434002 chr17:42200994 HDAC5 -0.45 -6.12 -0.32 2.66e-9 Total body bone mineral density; CRC cis rs4434138 0.664 rs62255364 chr3:52701502 C/T cg18099408 chr3:52552593 STAB1 -0.45 -7.37 -0.38 1.37e-12 Intelligence (multi-trait analysis); CRC cis rs11764590 0.950 rs55683212 chr7:2078855 G/C cg23378565 chr7:2036160 MAD1L1 -0.44 -6.34 -0.33 7.61e-10 Neuroticism; CRC cis rs2404602 0.647 rs11072620 chr15:77048770 T/A cg23625390 chr15:77176239 SCAPER -0.87 -14.35 -0.62 1.38e-36 Blood metabolite levels; CRC cis rs870825 0.616 rs745656 chr4:185637523 C/T cg04058563 chr4:185651563 MLF1IP 0.73 9.38 0.46 1.13e-18 Blood protein levels; CRC cis rs6694672 0.681 rs6670056 chr1:196982776 T/C cg13682187 chr1:196946512 CFHR5 0.52 8.05 0.41 1.56e-14 Asthma; CRC trans rs2303319 0.504 rs41267437 chr2:162627391 G/A cg27342122 chr8:133787442 PHF20L1 -0.74 -6.0 -0.31 5.3300000000000004e-09 Cognitive function; CRC cis rs6952808 0.531 rs3779002 chr7:2183219 C/T cg22963979 chr7:1858916 MAD1L1 -0.42 -5.88 -0.31 1.01e-8 Bipolar disorder and schizophrenia; CRC cis rs7589342 0.929 rs6719896 chr2:106428404 C/G cg16077055 chr2:106428750 NCK2 -0.4 -5.77 -0.3 1.87e-8 Addiction; CRC cis rs10504229 0.906 rs7003285 chr8:58173108 A/G cg22535103 chr8:58192502 C8orf71 -0.82 -12.27 -0.56 9.63e-29 Developmental language disorder (linguistic errors); CRC cis rs10504229 0.683 rs7822631 chr8:58130916 C/G cg22535103 chr8:58192502 C8orf71 -0.7 -9.34 -0.46 1.47e-18 Developmental language disorder (linguistic errors); CRC cis rs801193 0.548 rs2659891 chr7:66201114 A/G cg00343986 chr7:65444356 GUSB 0.44 6.15 0.32 2.21e-9 Aortic root size; CRC cis rs4728302 0.534 rs6976069 chr7:133152898 T/C cg10665199 chr7:133106180 EXOC4 0.57 8.71 0.43 1.56e-16 Intelligence;Intelligence (multi-trait analysis); CRC cis rs7591163 1.000 rs6436741 chr2:228714598 G/A cg22079747 chr2:228736145 WDR69 -0.44 -5.88 -0.31 1.01e-8 Blood pressure; CRC cis rs938554 0.657 rs7679724 chr4:9985376 G/T cg00071950 chr4:10020882 SLC2A9 0.41 6.13 0.32 2.45e-9 Blood metabolite levels; CRC cis rs3806843 0.801 rs2531358 chr5:140117437 A/G cg16607685 chr5:140181889 PCDHA2;PCDHA1;PCDHA3 0.26 6.02 0.32 4.54e-9 Depressive symptoms (multi-trait analysis); CRC cis rs7584330 0.910 rs72620830 chr2:238396985 C/T cg14458575 chr2:238380390 NA 0.74 13.53 0.6 1.76e-33 Prostate cancer; CRC cis rs7591163 1.000 rs4973380 chr2:228725402 T/A cg21577049 chr2:228736449 WDR69 -0.44 -5.88 -0.31 9.88e-9 Blood pressure; CRC cis rs7216064 0.684 rs62084675 chr17:66027025 A/G cg12091567 chr17:66097778 LOC651250 0.9 13.68 0.6 5e-34 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CRC cis rs853679 0.517 rs2275508 chr6:28094731 T/C cg02631126 chr6:28058918 ZSCAN12L1 0.28 5.68 0.3 2.9e-8 Depression; CRC cis rs11122272 0.637 rs2808593 chr1:231524228 G/T cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.54 -8.14 -0.41 7.99e-15 Hemoglobin concentration; CRC cis rs524281 0.861 rs7941469 chr11:65900152 A/G cg16950941 chr11:66035639 RAB1B 0.57 7.45 0.38 8.35e-13 Electroencephalogram traits; CRC cis rs4481887 0.893 rs4576683 chr1:248472390 T/C cg00666640 chr1:248458726 OR2T12 0.46 7.9 0.4 4.19e-14 Common traits (Other); CRC cis rs3858526 0.584 rs10769271 chr11:5860572 T/C cg05234568 chr11:5960015 NA -0.63 -8.83 -0.44 6.39e-17 DNA methylation (variation); CRC cis rs9304742 0.962 rs12150933 chr19:53455221 A/G cg09915433 chr19:53449742 NA -0.6 -9.1 -0.45 8.63e-18 Psoriasis; CRC cis rs9462027 0.628 rs2744949 chr6:34633862 C/T cg07306190 chr6:34760872 UHRF1BP1 -0.35 -6.32 -0.33 8.5e-10 Systemic lupus erythematosus; CRC cis rs6460942 0.630 rs62451487 chr7:12390464 G/A cg06484146 chr7:12443880 VWDE -0.62 -6.42 -0.33 4.87e-10 Coronary artery disease; CRC cis rs727479 0.502 rs2289106 chr15:51507782 T/G cg19946085 chr15:51559439 CYP19A1 -0.3 -6.08 -0.32 3.38e-9 Estradiol levels; CRC cis rs2625529 0.689 rs12898868 chr15:72112918 A/G cg16672083 chr15:72433130 SENP8 0.43 6.41 0.33 5.11e-10 Red blood cell count; CRC cis rs11785400 1.000 rs3735994 chr8:143742683 C/T cg24634471 chr8:143751801 JRK 0.53 7.55 0.38 4.46e-13 Schizophrenia; CRC cis rs28735056 0.904 rs11665111 chr18:77622996 T/C cg12845895 chr18:77676008 PQLC1 0.41 5.94 0.31 7.32e-9 Schizophrenia; CRC cis rs16975963 0.843 rs77895245 chr19:38419780 G/C cg15135657 chr19:38346511 NA -0.44 -5.92 -0.31 7.99e-9 Longevity; CRC cis rs11168351 0.926 rs10875719 chr12:48411158 T/C cg24011408 chr12:48396354 COL2A1 0.43 6.33 0.33 8.06e-10 Bipolar disorder and schizophrenia; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg09466831 chr16:47071686 NA 0.42 6.95 0.36 1.93e-11 Liver disease severity in Alagille syndrome; CRC cis rs6089584 0.586 rs4925216 chr20:60599923 G/A cg23463467 chr20:60627584 TAF4 0.39 7.44 0.38 8.93e-13 Body mass index; CRC cis rs13082711 0.501 rs428239 chr3:27555566 G/C cg02860705 chr3:27208620 NA -0.41 -6.08 -0.32 3.34e-9 Systolic blood pressure;Diastolic blood pressure;Blood pressure; CRC cis rs1707322 1.000 rs9793167 chr1:46446800 G/A cg03146154 chr1:46216737 IPP 0.51 7.06 0.36 1.01e-11 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs4481887 0.927 rs4244187 chr1:248493511 T/C cg13385794 chr1:248469461 NA 0.38 6.57 0.34 1.93e-10 Common traits (Other); CRC cis rs2898681 0.642 rs62336790 chr4:53728000 T/C cg00338735 chr4:53728038 RASL11B 0.41 6.48 0.34 3.25e-10 Optic nerve measurement (cup area); CRC cis rs9733 0.596 rs6686525 chr1:150635811 C/T cg17724175 chr1:150552817 MCL1 0.59 9.47 0.46 5.5e-19 Tonsillectomy; CRC cis rs28386778 0.897 rs6504184 chr17:61842408 A/T cg06873352 chr17:61820015 STRADA 0.79 14.96 0.64 5.82e-39 Prudent dietary pattern; CRC cis rs6545883 0.929 rs2121660 chr2:61653058 T/C cg15711740 chr2:61764176 XPO1 0.46 6.11 0.32 2.81e-9 Tuberculosis; CRC cis rs780096 0.505 rs12475426 chr2:27599132 G/A cg12648201 chr2:27665141 KRTCAP3 -0.29 -5.74 -0.3 2.11e-8 Total body bone mineral density; CRC cis rs2204008 0.806 rs35534445 chr12:38279093 C/T cg13010199 chr12:38710504 ALG10B 0.44 5.64 0.3 3.66e-8 Bladder cancer; CRC cis rs4713118 0.869 rs6901520 chr6:27714575 G/T cg03623178 chr6:28175578 NA 0.67 9.54 0.47 3.41e-19 Parkinson's disease; CRC cis rs6714710 0.603 rs6738389 chr2:98386731 A/G cg26665480 chr2:98280029 ACTR1B 0.53 7.19 0.37 4.36e-12 Posterior cortical atrophy and Alzheimer's disease; CRC cis rs2014572 0.967 rs10412975 chr19:57770554 C/A cg24459738 chr19:57751996 ZNF805 -0.58 -9.16 -0.45 5.49e-18 Hyperactive-impulsive symptoms; CRC cis rs7647973 0.626 rs7649428 chr3:49868876 A/T cg13072238 chr3:49761600 GMPPB 0.51 5.81 0.31 1.48e-8 Menarche (age at onset); CRC cis rs2180341 0.961 rs3798857 chr6:127659473 A/T cg24812749 chr6:127587940 RNF146 0.94 13.66 0.6 5.88e-34 Breast cancer; CRC cis rs9368481 0.761 rs12661756 chr6:27003483 A/G cg18278486 chr6:26987575 LOC100270746;C6orf41 0.52 8.23 0.41 4.42e-15 Autism spectrum disorder or schizophrenia; CRC cis rs10242455 0.702 rs1045012 chr7:98984354 G/C cg18809830 chr7:99032528 PTCD1 -1.11 -7.97 -0.4 2.72e-14 Blood metabolite levels; CRC cis rs4713118 0.696 rs2394002 chr6:27748015 G/A cg06470822 chr6:28175283 NA 0.75 10.09 0.49 5.07e-21 Parkinson's disease; CRC cis rs1552244 1.000 rs58275763 chr3:10143274 C/T cg08888203 chr3:10149979 C3orf24 0.73 10.19 0.49 2.19e-21 Alzheimer's disease; CRC cis rs2004318 1.000 rs2004318 chr19:55138232 C/T cg03320607 chr19:54800032 LILRA3 -0.75 -6.0 -0.31 5.26e-9 Blood protein levels; CRC cis rs965469 0.779 rs6037528 chr20:3260978 A/G cg25506879 chr20:3388711 C20orf194 -0.37 -5.78 -0.3 1.75e-8 IFN-related cytopenia; CRC cis rs9649213 0.593 rs36017146 chr7:97974617 C/T cg00277769 chr7:97922759 BAIAP2L1 -0.6 -10.45 -0.5 3e-22 Prostate cancer (SNP x SNP interaction); CRC cis rs644799 1.000 rs632388 chr11:95563775 A/G cg03916912 chr11:95522834 CEP57;FAM76B 0.95 18.38 0.71 2.03e-52 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs2290159 0.948 rs73130305 chr3:12621075 C/T cg23032965 chr3:12705835 RAF1 0.43 5.61 0.3 4.3e-8 Cholesterol, total; CRC cis rs35264875 0.796 rs72928657 chr11:68852336 T/C cg23740940 chr11:68924746 NA 0.44 5.77 0.3 1.82e-8 Blond vs. brown hair color; CRC cis rs2404602 1.000 rs12148786 chr15:76800362 A/G cg03037974 chr15:76606532 NA 0.58 9.59 0.47 2.34e-19 Blood metabolite levels; CRC cis rs6952808 0.929 rs12667688 chr7:1931030 C/T cg21782813 chr7:2030301 MAD1L1 0.49 8.37 0.42 1.72e-15 Bipolar disorder and schizophrenia; CRC cis rs4722166 0.695 rs6946509 chr7:22809490 T/C cg05472934 chr7:22766657 IL6 0.67 10.82 0.51 1.55e-23 Lung cancer; CRC cis rs7932354 0.528 rs4752952 chr11:47082858 T/C cg03339077 chr11:47165057 C11orf49 0.43 6.1 0.32 2.96e-9 Bone mineral density (hip);Bone mineral density; CRC cis rs3741151 0.881 rs79623427 chr11:73094896 C/T cg17517138 chr11:73019481 ARHGEF17 1.03 8.08 0.41 1.28e-14 GIP levels in response to oral glucose tolerance test (120 minutes); CRC trans rs6076960 0.622 rs6054063 chr20:6262992 C/A cg17788362 chr6:86352627 SYNCRIP 0.47 6.55 0.34 2.17e-10 Smooth-surface caries; CRC cis rs3106136 0.546 rs2664880 chr4:95144177 T/A cg11021082 chr4:95130006 SMARCAD1 -0.59 -9.46 -0.46 6.05e-19 Capecitabine sensitivity; CRC cis rs1215050 0.740 rs1084784 chr4:98961711 T/G cg05340658 chr4:99064831 C4orf37 -0.48 -7.35 -0.38 1.54e-12 Waist-to-hip ratio adjusted for body mass index; CRC trans rs1490453 0.629 rs6829009 chr4:149247221 G/C cg26605335 chr17:4689165 VMO1 -0.35 -6.12 -0.32 2.7e-9 Biochemical measures; CRC trans rs7618501 1.000 rs60205400 chr3:49800272 C/T cg21582582 chr3:182698605 DCUN1D1 0.55 8.02 0.4 1.84e-14 Intelligence (multi-trait analysis); CRC cis rs1862618 0.802 rs252900 chr5:56185281 T/A cg18230493 chr5:56204884 C5orf35 -0.75 -9.27 -0.45 2.61e-18 Initial pursuit acceleration; CRC cis rs9814567 0.806 rs7648616 chr3:134318074 C/T cg06541857 chr3:134203789 ANAPC13;CEP63 -0.37 -5.73 -0.3 2.3e-8 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs7289126 1.000 rs4820328 chr22:38635679 C/T cg25457927 chr22:38595422 NA -0.3 -5.99 -0.31 5.36e-9 Mammographic density (dense area);Percent mammographic density; CRC cis rs7635838 0.859 rs7632040 chr3:11427455 A/G cg00170343 chr3:11313890 ATG7 0.4 6.15 0.32 2.28e-9 HDL cholesterol; CRC cis rs7586879 0.964 rs4077679 chr2:25122852 T/C cg04586622 chr2:25135609 ADCY3 -0.42 -6.95 -0.36 1.92e-11 Body mass index; CRC cis rs4268898 0.552 rs4665663 chr2:24372139 G/C cg06627628 chr2:24431161 ITSN2 0.46 6.96 0.36 1.83e-11 Asthma; CRC trans rs208520 0.690 rs12213928 chr6:66762978 G/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 1.04 14.51 0.62 3.17e-37 Exhaled nitric oxide output; CRC cis rs1018836 0.923 rs1476427 chr8:91552791 A/G cg16814680 chr8:91681699 NA 0.77 13.12 0.59 6.42e-32 Ejection fraction in Tripanosoma cruzi seropositivity; CRC cis rs6912958 0.703 rs12207825 chr6:88098292 C/T cg08069147 chr6:88032118 GJB7;C6orf162 0.73 11.56 0.54 3.61e-26 Monocyte percentage of white cells; CRC cis rs826838 0.586 rs1843903 chr12:38627524 C/T cg26384229 chr12:38710491 ALG10B 0.49 7.12 0.37 6.81e-12 Heart rate; CRC cis rs6604026 0.656 rs2255723 chr1:93368309 A/C cg22128645 chr1:93425802 FAM69A -0.37 -5.7 -0.3 2.64e-8 Multiple sclerosis; CRC cis rs6479527 1.000 rs6479527 chr9:96858411 G/A cg14459158 chr9:96720562 NA 0.43 7.52 0.38 5.12e-13 Esophageal adenocarcinoma; CRC cis rs6429082 1.000 rs6429082 chr1:235600129 C/T cg26050004 chr1:235667680 B3GALNT2 0.41 5.9 0.31 9.24e-9 Adiposity; CRC cis rs7659604 1.000 rs28532673 chr4:122664323 A/G cg19748678 chr4:122722346 EXOSC9 -0.56 -9.14 -0.45 6.69e-18 Type 2 diabetes; CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg01593552 chr13:22185680 NA -0.35 -6.0 -0.31 5.12e-9 Obesity-related traits; CRC cis rs208520 0.837 rs208509 chr6:66941706 A/G cg07460842 chr6:66804631 NA -0.96 -12.47 -0.57 1.73e-29 Exhaled nitric oxide output; CRC cis rs9527 0.590 rs726010 chr10:104841977 C/T cg04362960 chr10:104952993 NT5C2 0.59 8.16 0.41 7.36e-15 Arsenic metabolism; CRC trans rs7819412 0.740 rs7844536 chr8:11034028 A/G cg06636001 chr8:8085503 FLJ10661 -0.52 -7.91 -0.4 3.99e-14 Triglycerides; CRC cis rs1448094 0.512 rs7134732 chr12:86241908 T/C cg02569458 chr12:86230093 RASSF9 0.42 7.24 0.37 3.17e-12 Major depressive disorder; CRC cis rs2239547 0.522 rs6773040 chr3:52935428 C/A cg10802521 chr3:52805072 NEK4 0.44 5.99 0.31 5.39e-9 Schizophrenia; CRC cis rs3008870 0.755 rs1570838 chr1:67403315 C/T cg08660285 chr1:67390436 MIER1;WDR78 0.55 7.72 0.39 1.37e-13 Lymphocyte percentage of white cells; CRC cis rs9611565 0.649 rs5758442 chr22:42133060 T/C cg03806693 chr22:41940476 POLR3H 0.66 9.31 0.46 1.9e-18 Vitiligo; CRC cis rs3749237 0.595 rs3870337 chr3:49557095 G/T cg03060546 chr3:49711283 APEH 0.61 10.29 0.49 1.05e-21 Resting heart rate; CRC cis rs28386778 0.897 rs716880 chr17:61902822 C/G cg22520471 chr17:61851767 DDX42;CCDC47 0.75 11.75 0.54 7.35e-27 Prudent dietary pattern; CRC cis rs858239 1.000 rs199357 chr7:23288309 A/G cg18081818 chr7:23246105 NA 0.34 5.89 0.31 9.74e-9 Cerebrospinal fluid biomarker levels; CRC trans rs7395662 1.000 rs7482176 chr11:48604620 C/G cg21153622 chr11:89784906 NA -0.45 -7.17 -0.37 5.01e-12 HDL cholesterol; CRC cis rs17209837 0.915 rs17149637 chr7:87085209 G/A cg00919237 chr7:87102261 ABCB4 -0.49 -6.03 -0.32 4.4e-9 Gallbladder cancer; CRC cis rs11190604 1.000 rs3793706 chr10:102269085 A/C cg07080220 chr10:102295463 HIF1AN -0.46 -5.72 -0.3 2.41e-8 Palmitoleic acid (16:1n-7) levels; CRC cis rs8067545 0.611 rs1373146 chr17:20206675 G/A cg13482628 chr17:19912719 NA -0.47 -7.52 -0.38 5.29e-13 Schizophrenia; CRC cis rs6598955 0.671 rs11247914 chr1:26648838 G/T cg00852783 chr1:26633632 UBXN11 -0.5 -5.87 -0.31 1.08e-8 Obesity-related traits; CRC trans rs7395662 1.000 rs7479134 chr11:48625409 A/C cg21153622 chr11:89784906 NA -0.44 -7.09 -0.36 8.32e-12 HDL cholesterol; CRC cis rs9322193 0.962 rs9767122 chr6:150104689 T/G cg13206674 chr6:150067644 NUP43 0.57 8.14 0.41 8.29e-15 Lung cancer; CRC cis rs7259376 0.840 rs3862494 chr19:22519522 G/A cg02657401 chr19:22469223 NA -0.37 -8.2 -0.41 5.42e-15 Menopause (age at onset); CRC trans rs10242455 1.000 rs73395547 chr7:98922746 C/A cg09045935 chr12:6379348 NA 0.74 6.98 0.36 1.67e-11 Blood metabolite levels; CRC cis rs853679 0.517 rs9380059 chr6:28132358 A/C cg06470822 chr6:28175283 NA 1.03 13.59 0.6 1.04e-33 Depression; CRC cis rs10504229 1.000 rs55944282 chr8:58180821 A/G cg02290350 chr8:58132656 NA -0.42 -5.96 -0.31 6.62e-9 Developmental language disorder (linguistic errors); CRC trans rs7726839 0.574 rs11134149 chr5:637277 A/G cg11887960 chr12:57824829 NA 0.55 6.59 0.34 1.75e-10 Obesity-related traits; CRC cis rs10256972 0.681 rs6979076 chr7:1116247 C/T cg07308232 chr7:1071921 C7orf50 0.45 6.18 0.32 1.91e-9 Longevity;Endometriosis; CRC cis rs2243480 1.000 rs466983 chr7:65520496 T/G cg25985355 chr7:65971099 NA -0.54 -6.09 -0.32 3.18e-9 Diabetic kidney disease; CRC cis rs853679 0.517 rs9368551 chr6:28061792 A/G cg02683197 chr6:28174875 NA 0.82 10.03 0.48 7.9e-21 Depression; CRC cis rs11764590 0.715 rs9639202 chr7:2087315 G/A cg02825527 chr7:2087843 MAD1L1 -0.5 -6.07 -0.32 3.49e-9 Neuroticism; CRC cis rs561341 0.883 rs7219239 chr17:30212016 A/G cg12193833 chr17:30244370 NA 0.56 6.92 0.36 2.32e-11 Hip circumference adjusted for BMI; CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg05485520 chr3:45883628 LZTFL1 -0.52 -6.4 -0.33 5.31e-10 Diisocyanate-induced asthma; CRC cis rs28386778 0.897 rs8077013 chr17:61850392 C/T cg06601766 chr17:61851465 DDX42;CCDC47 0.45 6.1 0.32 3.06e-9 Prudent dietary pattern; CRC cis rs2836974 0.666 rs1888487 chr21:40683259 A/G cg06238570 chr21:40685208 BRWD1 -0.83 -13.34 -0.59 9.28e-33 Cognitive function; CRC cis rs9311474 0.507 rs6787154 chr3:52784416 C/T cg15147215 chr3:52552868 STAB1 -0.63 -10.68 -0.51 4.84e-23 Electroencephalogram traits; CRC trans rs61931739 0.534 rs11053073 chr12:34202412 C/T cg26384229 chr12:38710491 ALG10B 0.54 6.87 0.35 3.22e-11 Morning vs. evening chronotype; CRC cis rs7408868 1.000 rs10418305 chr19:15278808 C/G cg14696996 chr19:15285081 NOTCH3 0.96 8.96 0.44 2.53e-17 Pulse pressure; CRC cis rs1577917 0.710 rs9342041 chr6:86280875 G/A cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A 0.56 7.76 0.39 1.11e-13 Response to antipsychotic treatment; CRC cis rs6479527 0.806 rs2153058 chr9:96746126 A/G cg14459158 chr9:96720562 NA -0.41 -7.57 -0.39 3.8e-13 Esophageal adenocarcinoma; CRC cis rs992157 0.835 rs6729058 chr2:219148369 G/A cg00012203 chr2:219082015 ARPC2 -0.47 -7.1 -0.36 7.83e-12 Colorectal cancer; CRC cis rs1707322 0.721 rs7520123 chr1:46235219 C/G cg06784218 chr1:46089804 CCDC17 0.55 9.92 0.48 1.8e-20 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs6748734 1.000 rs6748734 chr2:241837452 A/G cg04034577 chr2:241836375 C2orf54 -0.41 -8.67 -0.43 2.01e-16 Urinary metabolites; CRC cis rs17767392 0.846 rs12884929 chr14:71788946 C/T cg13720639 chr14:72061746 SIPA1L1 -0.47 -6.18 -0.32 1.93e-9 Mitral valve prolapse; CRC cis rs990171 1.000 rs6746271 chr2:103052995 G/C cg03938978 chr2:103052716 IL18RAP 0.46 5.91 0.31 8.41e-9 Lymphocyte counts; CRC cis rs9858542 0.953 rs9818590 chr3:49525096 A/G cg07274523 chr3:49395745 GPX1 0.46 6.23 0.32 1.43e-9 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs921968 0.643 rs520095 chr2:219329485 C/T cg02176678 chr2:219576539 TTLL4 0.49 8.05 0.41 1.58e-14 Mean corpuscular hemoglobin concentration; CRC cis rs2204008 0.668 rs1619009 chr12:38120485 G/A cg13010199 chr12:38710504 ALG10B -0.42 -6.13 -0.32 2.53e-9 Bladder cancer; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg01753003 chr11:85565989 CCDC83 0.37 6.72 0.35 8.22e-11 Liver disease severity in Alagille syndrome; CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg03952484 chr1:149899818 SF3B4 -0.53 -6.32 -0.33 8.31e-10 Diisocyanate-induced asthma; CRC cis rs35306767 0.807 rs12768348 chr10:899224 T/G cg26597838 chr10:835615 NA 1.23 14.8 0.63 2.42e-38 Eosinophil percentage of granulocytes; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg03262242 chr1:28559476 DNAJC8 0.4 6.13 0.32 2.56e-9 Liver disease severity in Alagille syndrome; CRC cis rs7615952 0.599 rs67566088 chr3:125768973 C/A cg06494592 chr3:125709126 NA -0.57 -6.78 -0.35 5.61e-11 Blood pressure (smoking interaction); CRC cis rs873946 0.517 rs2803990 chr10:134560340 A/G cg27286337 chr10:134555280 INPP5A 0.68 9.37 0.46 1.2e-18 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CRC cis rs3767633 0.925 rs924777 chr1:161848904 G/A cg09175582 chr1:161736000 ATF6 0.7 6.29 0.33 1.03e-9 IgG glycosylation; CRC cis rs7552404 0.731 rs5745491 chr1:76350159 T/G cg22875332 chr1:76189707 ACADM -0.59 -7.42 -0.38 1.03e-12 Blood metabolite levels;Acylcarnitine levels; CRC cis rs910316 1.000 rs4903281 chr14:75554361 G/C cg11812906 chr14:75593930 NEK9 0.61 9.65 0.47 1.47e-19 Height; CRC cis rs1790761 0.504 rs61894496 chr11:67391907 C/T cg24690094 chr11:67383802 NA 0.4 7.33 0.37 1.84e-12 Mean corpuscular volume; CRC cis rs17065868 0.764 rs12146918 chr13:45035819 T/A cg10246903 chr13:45222710 NA 0.54 5.69 0.3 2.79e-8 Antineutrophil cytoplasmic antibody-associated vasculitis; CRC cis rs7727544 0.684 rs2516788 chr5:131715565 G/C cg07395648 chr5:131743802 NA 0.42 6.67 0.35 1.05e-10 Blood metabolite levels; CRC cis rs853679 0.517 rs1947863 chr6:28099344 G/A cg25164649 chr6:28176230 NA 0.76 9.53 0.46 3.71e-19 Depression; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg03680250 chr13:111567502 ANKRD10 0.41 6.02 0.31 4.53e-9 Intelligence (multi-trait analysis); CRC cis rs250677 0.687 rs40149 chr5:148444275 A/T cg18129178 chr5:148520854 ABLIM3 -0.4 -6.26 -0.33 1.22e-9 Breast cancer; CRC cis rs68170813 0.559 rs2395880 chr7:107074264 A/G cg02696742 chr7:106810147 HBP1 -0.51 -5.76 -0.3 1.94e-8 Coronary artery disease; CRC cis rs6499255 0.904 rs10852458 chr16:69672410 G/A cg00738113 chr16:70207722 CLEC18C -0.39 -6.14 -0.32 2.38e-9 IgE levels; CRC cis rs9303280 0.901 rs869402 chr17:38068043 C/T cg20243544 chr17:37824526 PNMT 0.42 6.57 0.34 1.97e-10 Self-reported allergy; CRC cis rs4363385 0.693 rs821755 chr1:153036245 G/C cg25856811 chr1:152973957 SPRR3 -0.24 -6.58 -0.34 1.87e-10 Inflammatory skin disease; CRC cis rs2455601 0.786 rs11042127 chr11:8947586 C/G cg09997546 chr11:8931473 C11orf17;ST5 -0.51 -6.85 -0.35 3.72e-11 Schizophrenia; CRC cis rs11148252 0.669 rs4884320 chr13:53006914 T/C cg00495681 chr13:53174319 NA 0.56 7.88 0.4 4.97e-14 Lewy body disease; CRC cis rs6951245 1.000 rs1881123 chr7:1084706 C/T cg24642844 chr7:1081250 C7orf50 -0.79 -9.4 -0.46 9.42e-19 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs200895692 1 rs200895692 chr1:43421956 CGCCTGTAATCCCAG/C cg00102166 chr1:43425337 SLC2A1 -0.43 -5.81 -0.3 1.48e-8 Monocyte count; CRC cis rs8180040 0.966 rs6790763 chr3:47572585 C/A cg02527881 chr3:46936655 PTH1R -0.39 -7.43 -0.38 9.66e-13 Colorectal cancer; CRC cis rs734999 0.588 rs2843401 chr1:2528133 T/C cg20673091 chr1:2541236 MMEL1 -0.37 -6.03 -0.32 4.31e-9 Ulcerative colitis; CRC cis rs6912958 0.667 rs7746545 chr6:88090225 A/G cg04972856 chr6:88032051 C6orf162;GJB7 0.33 6.16 0.32 2.17e-9 Monocyte percentage of white cells; CRC cis rs3806843 0.771 rs2563336 chr5:140107199 A/G cg19875535 chr5:140030758 IK -0.63 -10.37 -0.5 5.49e-22 Depressive symptoms (multi-trait analysis); CRC cis rs17711722 0.727 rs1880555 chr7:65432567 T/C cg18876405 chr7:65276391 NA 0.67 12.26 0.56 1.01e-28 Calcium levels; CRC cis rs73198271 0.531 rs11985640 chr8:8652504 C/T cg01851573 chr8:8652454 MFHAS1 0.55 6.84 0.35 3.76e-11 Bone ultrasound measurement (broadband ultrasound attenuation); CRC cis rs3741151 0.773 rs73546720 chr11:73252409 C/T cg17517138 chr11:73019481 ARHGEF17 0.95 7.78 0.39 9.74e-14 GIP levels in response to oral glucose tolerance test (120 minutes); CRC cis rs2030401 0.603 rs1727301 chr12:123664514 G/A cg00376283 chr12:123451042 ABCB9 0.43 5.67 0.3 3.08e-8 Intelligence (multi-trait analysis); CRC cis rs4654899 1.000 rs10916937 chr1:21439785 A/G cg02927042 chr1:21476669 EIF4G3 -0.51 -8.11 -0.41 1.03e-14 Superior frontal gyrus grey matter volume; CRC cis rs7666738 0.830 rs7657497 chr4:99044028 A/G cg05340658 chr4:99064831 C4orf37 0.6 9.35 0.46 1.36e-18 Colonoscopy-negative controls vs population controls; CRC cis rs798554 0.797 rs798488 chr7:2802522 T/C cg17321639 chr7:2759063 NA -0.47 -6.21 -0.32 1.59e-9 Height; CRC cis rs12936587 0.595 rs9911672 chr17:17528670 C/T cg24612305 chr17:17875800 TOM1L2;LRRC48 0.42 5.85 0.31 1.21e-8 Hip circumference;Coronary artery disease or large artery stroke;Coronary heart disease;Coronary artery disease; CRC cis rs3806843 0.801 rs801171 chr5:140115303 G/A cg19875535 chr5:140030758 IK -0.55 -8.8 -0.44 7.82e-17 Depressive symptoms (multi-trait analysis); CRC cis rs7552404 0.731 rs931507 chr1:76401577 G/A cg10523679 chr1:76189770 ACADM -0.62 -7.95 -0.4 2.94e-14 Blood metabolite levels;Acylcarnitine levels; CRC trans rs58688157 0.660 rs12797496 chr11:583767 C/T cg19188899 chr13:112838565 NA -0.41 -6.26 -0.33 1.19e-9 Systemic lupus erythematosus; CRC cis rs2797685 1.000 rs2859390 chr1:7847529 A/G cg04725166 chr1:7887271 PER3 -0.48 -5.92 -0.31 7.95e-9 Crohn's disease; CRC cis rs61160187 0.549 rs56031340 chr5:60253870 A/G cg16298547 chr5:60138761 ELOVL7 -0.27 -5.74 -0.3 2.17e-8 Educational attainment (years of education);Educational attainment (college completion); CRC cis rs9372498 0.536 rs9489452 chr6:118910868 G/C cg24463073 chr6:118973353 C6orf204 0.51 6.81 0.35 4.64e-11 Diastolic blood pressure; CRC cis rs898097 0.841 rs4986122 chr17:80825500 C/T cg15369054 chr17:80825471 TBCD 0.54 9.04 0.45 1.4e-17 Breast cancer; CRC cis rs4563143 0.663 rs5025682 chr19:29238670 A/C cg14983838 chr19:29218262 NA 0.57 8.64 0.43 2.52e-16 Methadone dose in opioid dependence; CRC cis rs7044106 0.791 rs10984995 chr9:123479210 C/T cg14255062 chr9:123606675 PSMD5;LOC253039 0.48 7.29 0.37 2.34e-12 Hip circumference adjusted for BMI; CRC cis rs7772486 0.754 rs9497401 chr6:146051271 T/C cg23711669 chr6:146136114 FBXO30 -0.73 -12.51 -0.57 1.22e-29 Lobe attachment (rater-scored or self-reported); CRC cis rs12024301 0.557 rs75330230 chr1:183592353 G/T cg11505048 chr1:183622726 RGL1;APOBEC4 0.76 6.93 0.36 2.16e-11 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs6460942 1.000 rs2033871 chr7:12405098 C/A cg20607287 chr7:12443886 VWDE -0.66 -6.87 -0.35 3.17e-11 Coronary artery disease; CRC cis rs10504229 0.593 rs17192845 chr8:58053339 C/T cg21724239 chr8:58056113 NA 0.79 9.61 0.47 1.91e-19 Developmental language disorder (linguistic errors); CRC cis rs10845606 1.000 rs10845609 chr12:12838920 T/A cg04607235 chr12:12878440 APOLD1 -0.56 -5.83 -0.31 1.32e-8 Systemic lupus erythematosus; CRC cis rs853679 0.546 rs200990 chr6:27815823 T/G cg03623178 chr6:28175578 NA 0.78 6.95 0.36 1.99e-11 Depression; CRC cis rs270601 0.721 rs270621 chr5:131605821 C/A cg18758796 chr5:131593413 PDLIM4 0.49 8.21 0.41 5.05e-15 Acylcarnitine levels; CRC cis rs365302 1.000 rs294918 chr6:159626072 C/T cg14500486 chr6:159655392 FNDC1 0.53 8.0 0.4 2.18e-14 Coronary heart disease; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg16311773 chr6:167313693 NA -0.46 -7.21 -0.37 3.8e-12 Liver disease severity in Alagille syndrome; CRC cis rs10876993 0.806 rs1689598 chr12:58050500 G/C cg15848620 chr12:58087721 OS9 -0.65 -8.89 -0.44 4.22e-17 Celiac disease or Rheumatoid arthritis; CRC cis rs13256369 1.000 rs9329165 chr8:8576642 C/T cg00074818 chr8:8560427 CLDN23 -0.38 -7.01 -0.36 1.34e-11 Obesity-related traits; CRC trans rs11075138 0.893 rs2865585 chr16:12728587 A/G cg24572153 chr13:21047387 CRYL1 0.42 6.16 0.32 2.09e-9 Cerebral amyloid angiopathy; CRC cis rs7618915 0.571 rs34954168 chr3:52612159 C/T cg07507251 chr3:52567010 NT5DC2 0.43 6.2 0.32 1.68e-9 Bipolar disorder; CRC cis rs887829 0.570 rs4553819 chr2:234594083 A/G cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.48 -7.45 -0.38 8.03e-13 Metabolic traits;Bilirubin levels;Cholelithiasis-related traits in sickle cell anemia;Metabolite levels;Total bilirubin levels in HIV-1 infection;Serum metabolite levels;Blood metabolite levels; CRC cis rs11785400 0.793 rs4736366 chr8:143742413 C/T cg24634471 chr8:143751801 JRK 0.5 6.67 0.34 1.11e-10 Schizophrenia; CRC cis rs72945132 0.882 rs6592522 chr11:70128271 G/A cg00319359 chr11:70116639 PPFIA1 0.65 6.71 0.35 8.57e-11 Coronary artery disease; CRC cis rs17401966 1.000 rs58053556 chr1:10442903 A/G cg19773385 chr1:10388646 KIF1B -0.55 -7.09 -0.36 8e-12 Hepatocellular carcinoma; CRC cis rs78456975 0.739 rs13405352 chr2:1518726 C/T cg26248373 chr2:1572462 NA -0.67 -8.15 -0.41 7.66e-15 Placebo response in major depressive disorder (% change in symptom score); CRC trans rs7176508 0.660 rs7180247 chr15:70046036 G/T cg06571387 chr2:176964101 HOXD12 -0.32 -5.98 -0.31 5.84e-9 Chronic lymphocytic leukemia; CRC trans rs800082 1.000 rs6440259 chr3:144286614 C/T cg24215973 chr2:240111563 HDAC4 0.46 6.62 0.34 1.43e-10 Smoking behavior; CRC trans rs2228479 0.702 rs62053701 chr16:89860584 G/A cg24644049 chr4:85504048 CDS1 0.83 6.97 0.36 1.69e-11 Skin colour saturation; CRC cis rs13118159 0.801 rs13147602 chr4:1332175 A/G cg20092199 chr4:1342459 KIAA1530 0.45 7.63 0.39 2.49e-13 Longevity; CRC cis rs853679 0.517 rs9348794 chr6:28117757 T/A cg06470822 chr6:28175283 NA 1.03 13.59 0.6 1.04e-33 Depression; CRC cis rs9341808 0.683 rs7771449 chr6:80919977 C/T cg08355045 chr6:80787529 NA 0.43 6.98 0.36 1.61e-11 Sitting height ratio; CRC cis rs1153858 1.000 rs12441971 chr15:45671957 A/T cg14582100 chr15:45693742 SPATA5L1 0.28 5.72 0.3 2.41e-8 Homoarginine levels; CRC cis rs2734839 0.964 rs12798900 chr11:113298996 G/T cg14159747 chr11:113255604 NA 0.48 8.52 0.43 5.75e-16 Information processing speed; CRC cis rs8180040 0.620 rs11720139 chr3:47036756 C/G cg10298567 chr3:47292165 KIF9 0.4 6.29 0.33 9.86e-10 Colorectal cancer; CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg01546243 chr14:61748019 TMEM30B -0.46 -5.96 -0.31 6.4e-9 Diisocyanate-induced asthma; CRC trans rs2243480 1.000 rs4145008 chr7:65647511 T/G cg10756647 chr7:56101905 PSPH -0.76 -7.87 -0.4 5.31e-14 Diabetic kidney disease; CRC cis rs524281 0.861 rs10896091 chr11:65950825 T/C cg16950941 chr11:66035639 RAB1B -0.6 -7.43 -0.38 9.29e-13 Electroencephalogram traits; CRC cis rs73200209 0.626 rs56159711 chr12:116578050 T/C cg01776926 chr12:116560359 MED13L -0.62 -7.14 -0.37 6.18e-12 Total body bone mineral density; CRC cis rs58688157 0.883 rs34793529 chr11:575800 T/G cg14433983 chr11:636460 DRD4 -0.42 -5.92 -0.31 8.17e-9 Systemic lupus erythematosus; CRC trans rs11039798 0.698 rs76315297 chr11:48240475 T/C cg15704280 chr7:45808275 SEPT13 0.69 6.73 0.35 7.46e-11 Axial length; CRC cis rs916888 0.610 rs199453 chr17:44800946 C/T cg15921436 chr17:44337874 NA 0.49 6.36 0.33 6.74e-10 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC trans rs16846053 0.681 rs62187569 chr2:162373517 A/G cg18122310 chr12:50236657 BCDIN3D -0.72 -6.07 -0.32 3.54e-9 Blood osmolality (transformed sodium); CRC cis rs7208859 0.673 rs999798 chr17:29158840 A/G cg14008862 chr17:28927542 LRRC37B2 0.51 6.17 0.32 1.98e-9 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs13108904 0.560 rs11247994 chr4:1343720 G/A cg23123621 chr4:1343375 KIAA1530 0.38 6.09 0.32 3.1e-9 Obesity-related traits; CRC cis rs911119 0.955 rs8121405 chr20:23605226 G/A cg16589663 chr20:23618590 CST3 0.45 6.35 0.33 7.25e-10 Chronic kidney disease; CRC cis rs9902453 0.933 rs9908901 chr17:28469713 G/A cg26525008 chr17:28256777 EFCAB5;SSH2 0.61 9.7 0.47 1.03e-19 Coffee consumption (cups per day); CRC trans rs61931739 0.500 rs11053268 chr12:34545121 T/C cg26384229 chr12:38710491 ALG10B 0.59 8.77 0.44 9.64e-17 Morning vs. evening chronotype; CRC cis rs910316 0.737 rs175510 chr14:75524839 G/A cg08847533 chr14:75593920 NEK9 -0.87 -15.37 -0.65 1.53e-40 Height; CRC cis rs13256369 1.000 rs7004438 chr8:8574379 C/T cg06636001 chr8:8085503 FLJ10661 0.44 5.78 0.3 1.77e-8 Obesity-related traits; CRC cis rs4478858 0.698 rs6655946 chr1:31805728 G/A cg07478791 chr1:31886160 SERINC2 -0.41 -5.79 -0.3 1.61e-8 Alcohol dependence; CRC cis rs11758351 0.866 rs11757394 chr6:26206694 G/C cg10723962 chr6:26240782 HIST1H4F -0.38 -6.0 -0.31 5.06e-9 Gout;Renal underexcretion gout; CRC cis rs11971779 0.938 rs28477480 chr7:139036058 C/T cg07862535 chr7:139043722 LUC7L2 -0.73 -8.55 -0.43 4.66e-16 Diisocyanate-induced asthma; CRC trans rs10411161 0.640 rs7252303 chr19:52389357 G/A cg22319618 chr22:45562946 NUP50 -0.62 -6.51 -0.34 2.78e-10 Breast cancer; CRC cis rs6951245 0.706 rs28522260 chr7:1183964 C/A cg18402987 chr7:1209562 NA 0.72 8.23 0.41 4.4e-15 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs10751667 0.560 rs10902267 chr11:1007831 T/C ch.11.42038R chr11:967971 AP2A2 0.58 8.96 0.44 2.53e-17 Alzheimer's disease (late onset); CRC cis rs523522 0.962 rs10774549 chr12:120891172 C/T cg12219531 chr12:120966889 COQ5 0.72 9.42 0.46 8.49e-19 High light scatter reticulocyte count; CRC cis rs9322193 0.923 rs9800871 chr6:149965676 A/G cg00933542 chr6:150070202 PCMT1 0.3 6.06 0.32 3.69e-9 Lung cancer; CRC cis rs1552244 0.882 rs13089863 chr3:10032259 G/T cg18598329 chr3:10140678 FANCD2;C3orf24 0.73 8.88 0.44 4.57e-17 Alzheimer's disease; CRC cis rs1448094 0.511 rs2405616 chr12:86148042 A/G cg18827107 chr12:86230957 RASSF9 0.39 5.96 0.31 6.52e-9 Major depressive disorder; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg03558299 chr20:47662597 CSE1L 0.49 6.91 0.36 2.56e-11 Response to antipsychotic treatment; CRC cis rs1003719 0.788 rs2835582 chr21:38458773 C/G cg10648535 chr21:38446584 PIGP;TTC3 0.53 7.46 0.38 7.62e-13 Eye color traits; CRC cis rs35306767 0.903 rs12244355 chr10:944465 T/C cg26597838 chr10:835615 NA 0.95 11.44 0.53 9.53e-26 Eosinophil percentage of granulocytes; CRC cis rs57221529 0.766 rs4081846 chr5:574019 G/A cg16447950 chr5:562315 NA -0.83 -11.08 -0.52 1.82e-24 Lung disease severity in cystic fibrosis; CRC cis rs875971 0.964 rs2277911 chr7:65958625 T/G cg12463550 chr7:65579703 CRCP 0.47 6.71 0.35 8.61e-11 Aortic root size; CRC cis rs10791323 0.559 rs10750548 chr11:133729469 A/G cg06766960 chr11:133703094 NA -0.38 -6.28 -0.33 1.1e-9 Childhood ear infection; CRC cis rs9858542 1.000 rs9858542 chr3:49701983 A/G cg03060546 chr3:49711283 APEH 0.51 7.04 0.36 1.13e-11 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs7927592 0.913 rs4316515 chr11:68308840 A/T cg01657329 chr11:68192670 LRP5 0.45 6.42 0.33 4.82e-10 Total body bone mineral density; CRC trans rs875971 0.660 rs2191268 chr7:66110224 C/T cg02243342 chr3:69129635 UBA3 -0.4 -6.03 -0.32 4.33e-9 Aortic root size; CRC cis rs754466 0.580 rs12357670 chr10:79558180 T/C cg26805224 chr10:79626177 DLG5 -0.5 -7.43 -0.38 9.72e-13 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs7487075 0.619 rs4768710 chr12:46808104 G/A cg22049899 chr12:47219821 SLC38A4 0.31 5.67 0.3 3.17e-8 Itch intensity from mosquito bite; CRC cis rs7692995 1.000 rs12511600 chr4:17939921 C/T cg08925142 chr4:18023851 LCORL -0.52 -5.81 -0.31 1.45e-8 Height; CRC cis rs9322193 0.923 rs9766886 chr6:149958184 T/C cg13206674 chr6:150067644 NUP43 0.65 9.76 0.47 6.33e-20 Lung cancer; CRC cis rs1267303 0.642 rs114746843 chr1:46999239 C/A cg08533674 chr1:46993347 NA -0.8 -10.42 -0.5 3.71e-22 Monobrow; CRC cis rs875971 0.862 rs11984115 chr7:65773859 C/T cg18876405 chr7:65276391 NA -0.53 -8.56 -0.43 4.37e-16 Aortic root size; CRC cis rs4819052 0.851 rs4819046 chr21:46664955 C/T cg11663144 chr21:46675770 NA -0.82 -13.93 -0.61 5.67e-35 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs7829975 0.540 rs2976909 chr8:8346690 C/T cg06636001 chr8:8085503 FLJ10661 -0.45 -6.26 -0.33 1.17e-9 Mood instability; CRC cis rs561341 1.000 rs576985 chr17:30323323 C/T cg19193384 chr17:30244184 NA -0.65 -7.57 -0.39 3.82e-13 Hip circumference adjusted for BMI; CRC cis rs6951245 1.000 rs74369356 chr7:1071711 T/C cg21664854 chr7:1097933 C7orf50;GPR146 0.79 8.92 0.44 3.39e-17 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs1552244 0.882 rs9757159 chr3:10039166 C/T cg10729496 chr3:10149963 C3orf24 0.49 6.34 0.33 7.69e-10 Alzheimer's disease; CRC cis rs17376456 0.877 rs9314092 chr5:93326362 A/G cg21475434 chr5:93447410 FAM172A 0.68 7.08 0.36 8.84e-12 Diabetic retinopathy; CRC cis rs11098499 0.691 rs2136911 chr4:120265859 G/A cg24375607 chr4:120327624 NA 0.47 7.68 0.39 1.89e-13 Corneal astigmatism; CRC cis rs6748734 0.843 rs6749674 chr2:241834501 G/C cg16358738 chr2:241808595 AGXT -0.39 -5.82 -0.31 1.4e-8 Urinary metabolites; CRC cis rs11190604 0.767 rs10883490 chr10:102194775 C/T cg16342193 chr10:102329863 NA -0.37 -5.95 -0.31 6.68e-9 Palmitoleic acid (16:1n-7) levels; CRC cis rs28386778 0.966 rs2008053 chr17:61954918 G/C cg06873352 chr17:61820015 STRADA 0.72 13.4 0.59 5.89e-33 Prudent dietary pattern; CRC cis rs7107174 0.688 rs869202 chr11:78127914 A/G cg02023728 chr11:77925099 USP35 0.4 6.07 0.32 3.52e-9 Testicular germ cell tumor; CRC cis rs910187 0.605 rs8124918 chr20:45811860 A/G cg27589058 chr20:45804311 EYA2 -0.4 -7.63 -0.39 2.5e-13 Migraine; CRC cis rs12479064 0.724 rs2309618 chr2:99974473 G/A cg14399236 chr2:99771627 LIPT1;TSGA10 -0.61 -7.25 -0.37 3.06e-12 Chronic sinus infection; CRC cis rs2985684 1.000 rs1957977 chr14:50090603 A/G cg04989706 chr14:50066350 PPIL5 -0.54 -7.52 -0.38 5.37e-13 Carotid intima media thickness; CRC cis rs425277 0.628 rs262662 chr1:2085033 A/G cg21194808 chr1:2205498 SKI 0.39 5.75 0.3 2.06e-8 Height; CRC cis rs589448 0.933 rs2249093 chr12:69753512 G/C cg20891283 chr12:69753455 YEATS4 0.99 21.36 0.76 4.12e-64 Cerebrospinal fluid biomarker levels; CRC cis rs6724607 1.000 rs11680758 chr2:191446268 T/G cg10560079 chr2:191398806 TMEM194B 0.45 6.41 0.33 5.01e-10 Pulse pressure; CRC trans rs12478296 0.685 rs67829386 chr2:242992276 T/A cg06834434 chr14:75079333 LTBP2 0.53 5.96 0.31 6.34e-9 Obesity-related traits; CRC cis rs4803468 1.000 rs2231940 chr19:41944237 T/C cg09537434 chr19:41945824 ATP5SL 0.96 17.82 0.7 3.29e-50 Height; CRC cis rs1707322 1.000 rs4660334 chr1:46462126 A/C cg06784218 chr1:46089804 CCDC17 0.51 8.81 0.44 7.58e-17 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs526821 0.595 rs504661 chr11:55312683 A/G cg04317927 chr11:55418816 OR4S2 0.39 6.51 0.34 2.83e-10 Pediatric bone mineral density (spine); CRC cis rs9372498 0.536 rs2356501 chr6:118942371 C/A cg22561889 chr6:118971681 C6orf204 0.52 6.62 0.34 1.45e-10 Diastolic blood pressure; CRC cis rs7932354 0.528 rs7121418 chr11:47165106 G/A cg19486271 chr11:47235900 DDB2 -0.47 -7.07 -0.36 9.57e-12 Bone mineral density (hip);Bone mineral density; CRC cis rs4757319 0.515 rs7109366 chr11:15438964 T/C cg03245590 chr11:15329459 NA 0.52 9.0 0.44 1.88e-17 Breast cancer; CRC cis rs916888 0.821 rs199506 chr17:44859031 A/G cg17911788 chr17:44343683 NA 0.57 7.02 0.36 1.27e-11 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs6714710 0.603 rs4311104 chr2:98424802 A/G cg26665480 chr2:98280029 ACTR1B 0.52 7.18 0.37 4.53e-12 Posterior cortical atrophy and Alzheimer's disease; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg03573702 chr19:44669354 ZNF226 0.41 6.07 0.32 3.53e-9 Response to antipsychotic treatment; CRC trans rs10982213 0.830 rs2274163 chr9:117188714 C/T cg12888358 chr2:86668281 KDM3A -0.55 -8.3 -0.42 2.75e-15 Interleukin-6 levels; CRC cis rs2032447 0.670 rs71557318 chr6:26118570 T/C cg12310025 chr6:25882481 NA 0.44 6.13 0.32 2.55e-9 Intelligence (multi-trait analysis); CRC cis rs12692738 0.526 rs355874 chr2:165632668 G/A cg03182029 chr2:165697222 COBLL1 0.5 5.86 0.31 1.11e-8 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);Waist-to-hip ratio adjusted for BMI in non-smokers;Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction);Waist-to-hip ratio adjusted for body mass index; CRC cis rs12477438 0.501 rs17759607 chr2:99737005 T/C cg14399236 chr2:99771627 LIPT1;TSGA10 0.74 12.36 0.56 4.57e-29 Chronic sinus infection; CRC cis rs7917772 0.690 rs11191369 chr10:104457456 G/A cg11453585 chr10:104263688 ACTR1A;SUFU 0.54 7.94 0.4 3.3e-14 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC cis rs1552244 1.000 rs17032278 chr3:10077955 A/G cg13047869 chr3:10149882 C3orf24 0.57 7.76 0.39 1.1e-13 Alzheimer's disease; CRC cis rs13064411 0.735 rs6438158 chr3:113217290 C/T cg10517650 chr3:113235015 CCDC52 -0.41 -7.18 -0.37 4.55e-12 Response to simvastatin treatment (PCSK9 protein level change); CRC cis rs853679 0.882 rs3757188 chr6:28107357 T/C cg03623178 chr6:28175578 NA 0.83 6.72 0.35 7.91e-11 Depression; CRC cis rs28735056 0.609 rs4799099 chr18:77639585 A/G cg20368463 chr18:77673604 PQLC1 0.66 10.6 0.5 8.91e-23 Schizophrenia; CRC cis rs11785400 0.793 rs9297972 chr8:143723660 C/T cg10596483 chr8:143751796 JRK 0.47 6.37 0.33 6.37e-10 Schizophrenia; CRC cis rs10781543 0.845 rs10781540 chr9:139321836 G/A cg14169450 chr9:139327907 INPP5E 0.37 5.9 0.31 8.79e-9 Monocyte percentage of white cells; CRC cis rs10504229 0.679 rs1596142 chr8:58032406 G/A cg02725872 chr8:58115012 NA -0.36 -6.18 -0.32 1.91e-9 Developmental language disorder (linguistic errors); CRC cis rs9322193 0.923 rs9377230 chr6:149934743 T/C cg05861140 chr6:150128134 PCMT1 -0.36 -5.94 -0.31 7.16e-9 Lung cancer; CRC cis rs798554 1.000 rs798548 chr7:2760935 A/G cg13628971 chr7:2884303 GNA12 0.48 6.77 0.35 5.98e-11 Height; CRC cis rs6743376 0.556 rs2515394 chr2:113817765 C/T cg24553058 chr2:113831203 IL1F10 0.42 6.9 0.36 2.69e-11 Inflammatory biomarkers; CRC cis rs8044868 0.530 rs7201866 chr16:72086534 A/T cg06172871 chr16:72088244 HP 0.42 6.1 0.32 2.97e-9 Body mass index (change over time) in cancer or chronic obstructive pulmonary disease;Body mass index (change over time) in cancer; CRC cis rs9393692 0.905 rs6931391 chr6:26279235 G/C cg00631329 chr6:26305371 NA -0.69 -13.61 -0.6 8.87e-34 Educational attainment; CRC cis rs77861329 1.000 rs1237830 chr3:52202820 T/C cg08692210 chr3:52188851 WDR51A 0.87 8.15 0.41 7.44e-15 Macrophage inflammatory protein 1b levels; CRC cis rs7212590 0.748 rs62081818 chr17:57890629 C/T cg10252138 chr17:58120427 NA -0.54 -5.64 -0.3 3.73e-8 Granulocyte percentage of myeloid white cells;Monocyte count;Monocyte percentage of white cells; CRC cis rs116095464 0.614 rs28736753 chr5:274081 G/A cg22496380 chr5:211416 CCDC127 -0.89 -10.15 -0.49 3.05e-21 Breast cancer; CRC cis rs6545883 0.929 rs10193666 chr2:61629408 C/T cg15711740 chr2:61764176 XPO1 0.44 5.83 0.31 1.3e-8 Tuberculosis; CRC cis rs9322193 0.923 rs10872651 chr6:150089409 A/T cg04369109 chr6:150039330 LATS1 -0.45 -6.0 -0.31 5.3e-9 Lung cancer; CRC trans rs1814175 0.817 rs1615305 chr11:49895222 T/A cg03929089 chr4:120376271 NA -0.98 -19.31 -0.73 4.62e-56 Height; CRC cis rs367615 0.679 rs4259216 chr5:108841817 A/G cg17395555 chr5:108820864 NA 0.46 9.37 0.46 1.23e-18 Colorectal cancer (SNP x SNP interaction); CRC cis rs2011503 0.882 rs8108777 chr19:19359058 C/A cg11584989 chr19:19387371 SF4 0.49 6.08 0.32 3.24e-9 Bipolar disorder; CRC cis rs9916302 0.904 rs8065879 chr17:37515978 G/A cg00129232 chr17:37814104 STARD3 0.53 7.99 0.4 2.36e-14 Glomerular filtration rate (creatinine); CRC cis rs4363385 0.818 rs382653 chr1:153006761 G/A cg25856811 chr1:152973957 SPRR3 -0.25 -6.99 -0.36 1.51e-11 Inflammatory skin disease; CRC cis rs55665837 1.000 rs10832254 chr11:14434698 A/G cg19336497 chr11:14380999 RRAS2 -0.39 -6.68 -0.35 1.02e-10 Vitamin D levels; CRC cis rs4713118 0.513 rs149942 chr6:28001610 T/C cg23161317 chr6:28129485 ZNF389 0.44 6.41 0.33 5.12e-10 Parkinson's disease; CRC cis rs59574136 1 rs59574136 chr7:2036460 T/C cg21782813 chr7:2030301 MAD1L1 0.53 9.16 0.45 5.56e-18 Autism spectrum disorder or schizophrenia; CRC cis rs10256972 0.616 rs6463001 chr7:1108272 A/C cg07308232 chr7:1071921 C7orf50 -0.43 -6.28 -0.33 1.06e-9 Longevity;Endometriosis; CRC cis rs1005277 0.579 rs1740749 chr10:38521646 A/G cg03665457 chr10:38645376 HSD17B7P2 -0.42 -5.96 -0.31 6.58e-9 Extrinsic epigenetic age acceleration; CRC cis rs2836974 0.627 rs7278985 chr21:40653767 C/T cg17971929 chr21:40555470 PSMG1 -0.72 -11.15 -0.52 1.05e-24 Cognitive function; CRC cis rs1065852 0.526 rs9611700 chr22:42401514 C/T cg22189786 chr22:42395067 WBP2NL 0.44 6.44 0.33 4.35e-10 Response to serotonin reuptake inhibitors in major depressive disorder (plasma drug and metabolite levels); CRC cis rs7493 0.755 rs62467350 chr7:94970114 T/C cg04155289 chr7:94953770 PON1 -0.57 -7.1 -0.36 7.6e-12 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs7044106 0.791 rs10984998 chr9:123481516 G/C cg09419670 chr9:123605666 PSMD5;LOC253039 0.75 12.27 0.56 9.17e-29 Hip circumference adjusted for BMI; CRC cis rs7715806 0.500 rs17649266 chr5:75001252 C/T cg00601450 chr5:74908170 NA -0.47 -5.82 -0.31 1.38e-8 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs1788820 0.917 rs1624695 chr18:21142992 A/T cg14672496 chr18:21087552 C18orf8 0.51 9.05 0.45 1.32e-17 Body mass index; CRC cis rs898097 0.737 rs3785521 chr17:80895769 A/G cg19046167 chr17:80928561 B3GNTL1 0.44 6.59 0.34 1.78e-10 Breast cancer; CRC cis rs12760731 0.565 rs34041572 chr1:178184493 T/C cg00404053 chr1:178313656 RASAL2 1.11 11.47 0.53 7.73e-26 Obesity-related traits; CRC cis rs12701220 0.894 rs10257744 chr7:1045612 C/T cg26769984 chr7:1090371 C7orf50 0.67 8.86 0.44 4.96e-17 Bronchopulmonary dysplasia; CRC cis rs910316 0.967 rs2010678 chr14:75567178 C/T cg08847533 chr14:75593920 NEK9 0.95 18.81 0.72 4.15e-54 Height; CRC cis rs72945132 0.660 rs12292191 chr11:70122426 T/C cg14191688 chr11:70257035 CTTN 0.4 5.69 0.3 2.8e-8 Coronary artery disease; CRC cis rs11212617 0.905 rs6589007 chr11:108040104 A/G cg12106634 chr11:108092400 ATM;NPAT 0.43 6.56 0.34 2.07e-10 Response to metformin in type 2 diabetes (glycemic); CRC cis rs11997175 0.583 rs7829680 chr8:33794207 C/T ch.8.33884649F chr8:33765107 NA -0.43 -6.13 -0.32 2.58e-9 Body mass index; CRC cis rs2737618 0.722 rs2821333 chr1:200093253 A/C cg21825944 chr1:200113062 NR5A2 -0.53 -7.42 -0.38 9.78e-13 Uric acid levels; CRC cis rs73206853 0.764 rs60339427 chr12:110824471 G/A cg12870014 chr12:110450643 ANKRD13A 0.84 10.0 0.48 1e-20 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC cis rs9816226 0.591 rs4234589 chr3:185818882 A/G cg00760338 chr3:185826511 ETV5 -0.64 -5.63 -0.3 3.93e-8 Obesity;Body mass index; CRC cis rs875971 1.000 rs6946143 chr7:65579722 A/C cg18876405 chr7:65276391 NA 0.51 8.91 0.44 3.49e-17 Aortic root size; CRC cis rs35110281 1.000 rs35110281 chr21:45068947 T/A cg04455712 chr21:45112962 RRP1B 0.41 7.92 0.4 3.73e-14 Mean corpuscular volume; CRC cis rs7937682 1.000 rs10502147 chr11:111569931 G/A cg09085632 chr11:111637200 PPP2R1B 1.03 19.12 0.73 2.56e-55 Primary sclerosing cholangitis; CRC cis rs6495367 0.898 rs2049176 chr15:79392548 A/C cg17916960 chr15:79447300 NA 0.4 6.3 0.33 9.49e-10 Spherical equivalent (joint analysis main effects and education interaction); CRC cis rs9910055 0.540 rs609292 chr17:42180436 G/A cg13607699 chr17:42295918 UBTF -0.54 -7.28 -0.37 2.54e-12 Total body bone mineral density; CRC cis rs6964587 0.967 rs34344935 chr7:91835436 G/A cg17063962 chr7:91808500 NA 0.79 12.38 0.56 3.72e-29 Breast cancer; CRC cis rs11190604 1.000 rs10883506 chr10:102289743 C/G cg07080220 chr10:102295463 HIF1AN 0.47 5.65 0.3 3.39e-8 Palmitoleic acid (16:1n-7) levels; CRC cis rs6426558 0.537 rs7523167 chr1:227365304 G/A cg10327440 chr1:227177885 CDC42BPA -0.42 -6.28 -0.33 1.09e-9 Neutrophil percentage of white cells; CRC cis rs4713118 0.512 rs2622319 chr6:28120401 G/C cg20615401 chr6:28092323 ZSCAN16 0.45 5.89 0.31 9.65e-9 Parkinson's disease; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg13919496 chr22:42915677 RRP7A 0.44 6.19 0.32 1.76e-9 Anxiety disorder; CRC cis rs7618915 0.501 rs62253740 chr3:52684128 A/T cg10802521 chr3:52805072 NEK4 -0.57 -9.02 -0.45 1.64e-17 Bipolar disorder; CRC trans rs116095464 0.558 rs28418643 chr5:240859 A/G cg00938859 chr5:1591904 SDHAP3 0.74 7.92 0.4 3.68e-14 Breast cancer; CRC cis rs3540 0.533 rs2256110 chr15:90971036 T/C cg22089800 chr15:90895588 ZNF774 0.56 9.44 0.46 6.91e-19 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg09728486 chr1:110577640 FAM40A 0.44 6.38 0.33 5.96e-10 Intelligence (multi-trait analysis); CRC cis rs12612619 0.677 rs2053386 chr2:27244712 C/T cg00617064 chr2:27272375 NA -0.36 -5.84 -0.31 1.26e-8 Venous thromboembolism adjusted for sickle cell variant rs77121243-T; CRC cis rs8005677 0.828 rs712486 chr14:23425041 A/G cg25600027 chr14:23388339 RBM23 -0.44 -6.42 -0.33 4.82e-10 Cognitive ability (multi-trait analysis); CRC cis rs9292777 0.777 rs12523046 chr5:40385241 A/T cg09067459 chr5:40385259 NA -0.56 -9.28 -0.46 2.31e-18 Crohn's disease;Multiple sclerosis; CRC cis rs7705042 0.897 rs4912807 chr5:141519296 G/C cg08523384 chr5:141488047 NDFIP1 -0.32 -5.71 -0.3 2.5e-8 Asthma; CRC cis rs17270561 0.609 rs12663099 chr6:25739518 C/T cg17691542 chr6:26056736 HIST1H1C 0.73 9.26 0.45 2.71e-18 Iron status biomarkers; CRC cis rs748404 0.587 rs690276 chr15:43704558 C/T cg02155558 chr15:43621948 ADAL;LCMT2 0.51 7.35 0.38 1.62e-12 Lung cancer; CRC cis rs78707713 0.531 rs12411720 chr10:71192471 T/G cg12610070 chr10:71211762 TSPAN15 -0.4 -7.21 -0.37 3.85e-12 Venous thromboembolism; CRC cis rs9486719 1.000 rs12205655 chr6:96891733 T/A cg06623918 chr6:96969491 KIAA0776 -0.81 -9.51 -0.46 4.17e-19 Migraine;Coronary artery disease; CRC cis rs853679 0.517 rs6922063 chr6:28094366 G/A cg12172441 chr6:28176163 NA 0.6 7.19 0.37 4.46e-12 Depression; CRC cis rs7428 0.527 rs6547612 chr2:85551184 C/T cg24342717 chr2:85555507 TGOLN2 -0.77 -12.63 -0.57 4.22e-30 Ear protrusion; CRC cis rs10761750 1 rs10761750 chr10:65128619 G/A cg08743896 chr10:65200160 JMJD1C -0.4 -5.74 -0.3 2.14e-8 Vascular endothelial growth factor levels; CRC cis rs9303401 0.614 rs34678056 chr17:57177549 G/A cg10487724 chr17:56770010 TEX14;RAD51C 0.69 8.54 0.43 5.13e-16 Cognitive test performance; CRC cis rs9379832 1 rs9379832 chr6:26186200 A/G cg13736514 chr6:26305472 NA -0.45 -7.03 -0.36 1.23e-11 Birth weight; CRC cis rs763121 0.853 rs2281021 chr22:39064667 T/C cg06544989 chr22:39130855 UNC84B 0.46 7.11 0.37 7.19e-12 Menopause (age at onset); CRC cis rs17125944 0.686 rs76673112 chr14:53366692 T/C cg00686598 chr14:53173677 PSMC6 0.87 7.47 0.38 7.52e-13 Alzheimer's disease (late onset); CRC cis rs3796352 1.000 rs11713206 chr3:52999243 A/G cg27565382 chr3:53032988 SFMBT1 0.77 6.12 0.32 2.67e-9 Immune reponse to smallpox (secreted IL-2); CRC cis rs1018836 0.828 rs9297870 chr8:91570691 C/G cg16814680 chr8:91681699 NA -0.64 -9.91 -0.48 1.94e-20 Ejection fraction in Tripanosoma cruzi seropositivity; CRC cis rs6951245 0.580 rs77101766 chr7:1122438 A/G cg22907277 chr7:1156413 C7orf50 0.88 11.27 0.53 3.84e-25 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs7647973 1.000 rs1982861 chr3:49577665 A/G cg20833759 chr3:49053208 WDR6;DALRD3 0.55 8.18 0.41 6.2e-15 Menarche (age at onset); CRC cis rs11212617 0.967 rs183460 chr11:108090710 A/C cg12106634 chr11:108092400 ATM;NPAT 0.44 6.33 0.33 7.9e-10 Response to metformin in type 2 diabetes (glycemic); CRC cis rs12760731 0.565 rs12028024 chr1:178087423 G/T cg00404053 chr1:178313656 RASAL2 1.07 11.37 0.53 1.67e-25 Obesity-related traits; CRC cis rs1707322 0.929 rs785500 chr1:46593044 C/T cg03146154 chr1:46216737 IPP -0.52 -7.08 -0.36 8.59e-12 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs9527 0.590 rs763914 chr10:104841587 T/C cg15744005 chr10:104629667 AS3MT -0.29 -5.84 -0.31 1.26e-8 Arsenic metabolism; CRC cis rs3924048 0.574 rs34494202 chr1:12612868 G/A cg23650765 chr1:12612165 NA 0.38 7.34 0.38 1.65e-12 Optic cup area; CRC cis rs7726839 1.000 rs7726839 chr5:618586 A/G cg09021430 chr5:549028 NA -0.73 -10.87 -0.51 9.87e-24 Obesity-related traits; CRC cis rs2066819 1.000 rs77853814 chr12:56687572 G/T cg26714650 chr12:56694279 CS -1.41 -11.64 -0.54 1.88e-26 Psoriasis vulgaris; CRC cis rs10870270 1.000 rs10159746 chr10:133742677 C/T cg08754478 chr10:133766260 PPP2R2D -0.65 -9.33 -0.46 1.63e-18 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; CRC cis rs10504229 0.645 rs56670121 chr8:58138872 C/T cg24829409 chr8:58192753 C8orf71 -0.54 -7.98 -0.4 2.4e-14 Developmental language disorder (linguistic errors); CRC cis rs8005677 1.000 rs8016061 chr14:23375809 A/G cg01529538 chr14:23388837 RBM23 0.39 6.19 0.32 1.78e-9 Cognitive ability (multi-trait analysis); CRC cis rs9549367 0.713 rs1323315 chr13:113859658 T/C cg18105134 chr13:113819100 PROZ 0.83 13.27 0.59 1.78e-32 Platelet distribution width; CRC trans rs6952808 0.771 rs10275045 chr7:1920826 C/T cg04565464 chr8:145669602 NFKBIL2 0.41 6.21 0.32 1.55e-9 Bipolar disorder and schizophrenia; CRC cis rs6582630 0.502 rs1589390 chr12:38416139 C/T cg13010199 chr12:38710504 ALG10B -0.4 -5.61 -0.3 4.38e-8 Drug-induced liver injury (flucloxacillin); CRC cis rs910316 0.763 rs175016 chr14:75459633 C/T cg11812906 chr14:75593930 NEK9 -0.58 -8.86 -0.44 5.26e-17 Height; CRC cis rs7811142 1.000 rs4463351 chr7:100078226 G/A cg00814883 chr7:100076585 TSC22D4 -0.74 -9.4 -0.46 9.54e-19 Platelet count; CRC cis rs763014 0.966 rs4984675 chr16:670117 T/C cg08989290 chr16:615782 NHLRC4 0.45 8.52 0.43 5.87e-16 Height; CRC cis rs9926296 0.605 rs12599180 chr16:89839306 C/T cg04287289 chr16:89883240 FANCA -0.8 -14.01 -0.61 2.73e-35 Vitiligo; CRC cis rs2228479 0.850 rs17233497 chr16:89815152 G/A cg06558623 chr16:89946397 TCF25 1.19 10.18 0.49 2.51e-21 Skin colour saturation; CRC cis rs6743376 0.556 rs2515397 chr2:113819258 T/C cg09040174 chr2:113837401 NA 0.44 6.44 0.33 4.3e-10 Inflammatory biomarkers; CRC cis rs12477438 0.520 rs13022329 chr2:99731189 A/T cg14399236 chr2:99771627 LIPT1;TSGA10 0.82 14.43 0.62 6.62e-37 Chronic sinus infection; CRC cis rs965469 0.901 rs7270135 chr20:3247922 T/C cg25506879 chr20:3388711 C20orf194 -0.38 -5.66 -0.3 3.29e-8 IFN-related cytopenia; CRC cis rs10924970 0.870 rs7531130 chr1:235440556 C/G cg26050004 chr1:235667680 B3GALNT2 0.41 6.1 0.32 2.96e-9 Asthma; CRC cis rs7833790 0.724 rs4739627 chr8:82734657 A/G cg27398817 chr8:82754497 SNX16 -0.43 -5.86 -0.31 1.13e-8 Diastolic blood pressure; CRC cis rs4141404 0.828 rs2413043 chr22:31648576 G/T cg07713946 chr22:31675144 LIMK2 -0.4 -5.79 -0.3 1.63e-8 Paclitaxel-induced neuropathy; CRC cis rs8060686 0.545 rs9922165 chr16:68181177 C/A cg08314208 chr16:67682810 RLTPR -0.47 -5.71 -0.3 2.55e-8 HDL cholesterol;Metabolic syndrome; CRC trans rs1814175 0.817 rs28525029 chr11:50045815 A/G cg15704280 chr7:45808275 SEPT13 -1.0 -20.79 -0.75 6.66e-62 Height; CRC cis rs77972916 0.561 rs17406174 chr2:43557484 C/G cg06169590 chr2:43455088 ZFP36L2;LOC100129726 -0.63 -5.93 -0.31 7.64e-9 Granulocyte percentage of myeloid white cells; CRC cis rs7843479 0.965 rs1484162 chr8:21831385 A/G cg17168535 chr8:21777572 XPO7 0.57 9.32 0.46 1.74e-18 Mean corpuscular volume; CRC cis rs9486715 0.867 rs9373907 chr6:96981189 G/A cg06623918 chr6:96969491 KIAA0776 0.98 18.17 0.71 1.44e-51 Headache; CRC cis rs17253792 0.822 rs10151664 chr14:56029533 A/G cg24579896 chr14:56047964 C14orf33;KTN1 0.69 6.14 0.32 2.35e-9 Putamen volume; CRC cis rs8170 1.000 rs67412075 chr19:17385502 A/G cg04749549 chr19:17459798 NA -0.43 -5.88 -0.31 1.01e-8 Breast cancer (estrogen-receptor negative);Breast Cancer in BRCA1 mutation carriers;Ovarian cancer;Breast cancer;Epithelial ovarian cancer; CRC cis rs1878931 0.624 rs27241 chr16:3447282 C/G cg26668626 chr16:3451006 ZNF174;ZNF434 -0.58 -7.12 -0.37 6.65e-12 Body mass index (adult); CRC cis rs3015497 0.789 rs3015502 chr14:51108427 T/C cg09863266 chr14:51125203 SAV1 -0.31 -5.8 -0.3 1.53e-8 Mean platelet volume; CRC cis rs10540 1.000 rs12801148 chr11:511707 T/G cg03352830 chr11:487213 PTDSS2 0.65 7.42 0.38 1.03e-12 Body mass index; CRC cis rs6684514 1.000 rs7522948 chr1:156275308 C/T cg16558208 chr1:156270281 VHLL 0.49 7.59 0.39 3.23e-13 Mean corpuscular hemoglobin concentration;Glycated hemoglobin levels; CRC cis rs6662572 0.774 rs9429188 chr1:46570879 A/T cg03123370 chr1:45965343 CCDC163P;MMACHC 0.49 6.38 0.33 6.09e-10 Blood protein levels; CRC cis rs5758659 1.000 rs134900 chr22:42683343 C/G cg15557168 chr22:42548783 NA -0.34 -5.88 -0.31 1.01e-8 Cognitive function; CRC trans rs1814175 0.935 rs11040463 chr11:49685574 C/T cg03929089 chr4:120376271 NA -0.94 -17.21 -0.69 8.36e-48 Height; CRC trans rs11250098 0.541 rs6997997 chr8:10766082 T/C cg08071915 chr8:12219732 FAM66A 0.34 6.01 0.31 4.92e-9 Morning vs. evening chronotype; CRC cis rs514406 0.861 rs503296 chr1:53283088 A/G cg24675658 chr1:53192096 ZYG11B 0.56 8.11 0.41 1.04e-14 Monocyte count; CRC cis rs939584 1.000 rs4854346 chr2:638918 A/C cg03610516 chr2:642275 NA 0.43 5.76 0.3 1.96e-8 Body mass index; CRC cis rs6570726 0.764 rs9403733 chr6:145912311 A/C cg13319975 chr6:146136371 FBXO30 -0.45 -6.65 -0.34 1.26e-10 Lobe attachment (rater-scored or self-reported); CRC cis rs7769051 0.522 rs3736725 chr6:133095172 A/G cg22852734 chr6:133119734 C6orf192 0.92 8.58 0.43 3.87e-16 Type 2 diabetes nephropathy; CRC cis rs561341 0.609 rs7209493 chr17:30197323 A/G cg13647721 chr17:30228624 UTP6 -0.61 -6.93 -0.36 2.17e-11 Hip circumference adjusted for BMI; CRC cis rs7613875 0.620 rs2526747 chr3:50082914 C/G cg24308560 chr3:49941425 MST1R -0.38 -5.73 -0.3 2.23e-8 Body mass index; CRC cis rs1448094 0.522 rs12313658 chr12:86271063 C/T cg18827107 chr12:86230957 RASSF9 -0.44 -7.14 -0.37 6.2e-12 Major depressive disorder; CRC cis rs853679 1.000 rs6905391 chr6:28262686 G/A cg21251018 chr6:28226885 NKAPL 0.5 5.86 0.31 1.15e-8 Depression; CRC cis rs9611565 0.592 rs1811113 chr22:42073134 C/T cg03806693 chr22:41940476 POLR3H 1.05 13.07 0.58 1.02e-31 Vitiligo; CRC cis rs9326248 1.000 rs9326248 chr11:116999225 A/C cg11861562 chr11:117069780 TAGLN 0.38 7.98 0.4 2.4e-14 Blood protein levels; CRC cis rs9467711 0.591 rs56195001 chr6:25976165 C/T cg08501292 chr6:25962987 TRIM38 0.79 7.15 0.37 5.67e-12 Autism spectrum disorder or schizophrenia; CRC trans rs11039571 0.588 rs61917001 chr11:48233667 G/C cg15704280 chr7:45808275 SEPT13 0.68 7.25 0.37 3e-12 D-dimer levels; CRC cis rs10751667 0.580 rs11246363 chr11:971667 T/C ch.11.42038R chr11:967971 AP2A2 0.58 10.08 0.49 5.46e-21 Alzheimer's disease (late onset); CRC cis rs12701220 0.553 rs7782024 chr7:1157502 G/T cg06145435 chr7:1022769 CYP2W1 0.4 6.16 0.32 2.11e-9 Bronchopulmonary dysplasia; CRC cis rs9311474 0.629 rs11709284 chr3:52559705 G/A cg17372223 chr3:52568218 NT5DC2 0.41 6.25 0.33 1.25e-9 Electroencephalogram traits; CRC cis rs2692947 0.832 rs2579519 chr2:96675166 T/C cg23100626 chr2:96804247 ASTL 0.26 7.14 0.37 6.05e-12 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; CRC cis rs3733585 0.588 rs6449154 chr4:9956404 C/T cg11266682 chr4:10021025 SLC2A9 -0.47 -9.69 -0.47 1.05e-19 Cleft plate (environmental tobacco smoke interaction); CRC cis rs7618915 0.547 rs62255362 chr3:52699741 C/G cg11645453 chr3:52864694 ITIH4 0.35 6.14 0.32 2.31e-9 Bipolar disorder; CRC cis rs1215050 0.655 rs6842706 chr4:98499037 A/T cg05340658 chr4:99064831 C4orf37 -0.44 -5.96 -0.31 6.47e-9 Waist-to-hip ratio adjusted for body mass index; CRC cis rs1865760 1.000 rs1865760 chr6:25916979 C/T cg16482183 chr6:26056742 HIST1H1C 0.55 7.96 0.4 2.84e-14 Height; CRC cis rs727563 0.608 rs2076200 chr22:41985956 G/T cg03806693 chr22:41940476 POLR3H -1.04 -11.6 -0.54 2.54e-26 Crohn's disease;Inflammatory bowel disease; CRC cis rs7618915 0.501 rs3733039 chr3:52719088 C/T cg11645453 chr3:52864694 ITIH4 0.36 6.57 0.34 1.97e-10 Bipolar disorder; CRC cis rs6062302 0.522 rs2297428 chr20:62221766 C/T cg06363034 chr20:62225388 GMEB2 -0.45 -6.95 -0.36 1.94e-11 Glioblastoma; CRC trans rs17780086 0.527 rs72827712 chr17:30538600 A/G cg20587970 chr11:113659929 NA -1.37 -15.11 -0.64 1.47e-39 Height; CRC cis rs10924970 0.649 rs12745603 chr1:235405211 G/A cg09010748 chr1:235293032 TOMM20 -0.41 -5.65 -0.3 3.48e-8 Asthma; CRC cis rs6570726 1.000 rs386678 chr6:145869010 A/G cg05347473 chr6:146136440 FBXO30 0.38 5.97 0.31 6.21e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs11864453 0.826 rs6499560 chr16:72147666 G/T cg23815491 chr16:72088622 HP -0.52 -8.08 -0.41 1.27e-14 Fibrinogen levels; CRC cis rs6545883 0.899 rs1562309 chr2:61770126 C/A cg15711740 chr2:61764176 XPO1 -0.52 -7.13 -0.37 6.21e-12 Tuberculosis; CRC cis rs12325245 0.536 rs12709002 chr16:58614337 A/C cg01472538 chr16:58549086 SETD6 0.98 6.32 0.33 8.72e-10 Schizophrenia; CRC trans rs2727020 0.681 rs2866362 chr11:49379316 A/G cg15704280 chr7:45808275 SEPT13 -0.89 -16.12 -0.66 1.73e-43 Coronary artery disease; CRC cis rs9894429 0.634 rs11655346 chr17:79572399 A/G cg21028142 chr17:79581711 NPLOC4 -0.34 -7.12 -0.37 6.79e-12 Eye color traits; CRC cis rs929354 0.772 rs3802125 chr7:156970563 A/C cg16102536 chr7:156981717 UBE3C 0.41 6.79 0.35 5.35e-11 Body mass index; CRC cis rs3820068 0.532 rs1547034 chr1:15919049 T/A cg27534772 chr1:16042836 PLEKHM2 0.54 10.62 0.51 7.54e-23 Systolic blood pressure; CRC cis rs7618501 0.633 rs2353579 chr3:50027774 C/T cg05623727 chr3:50126028 RBM5 0.45 7.63 0.39 2.55e-13 Intelligence (multi-trait analysis); CRC cis rs1129187 0.755 rs2274514 chr6:42934500 C/T cg05552183 chr6:42928497 GNMT 0.52 8.01 0.4 1.97e-14 Alzheimer's disease in APOE e4+ carriers; CRC cis rs4808199 0.895 rs10421505 chr19:19459554 C/T cg03709012 chr19:19516395 GATAD2A 0.94 11.94 0.55 1.5e-27 Nonalcoholic fatty liver disease; CRC cis rs10979 0.557 rs9390117 chr6:143907590 C/T cg25407410 chr6:143891975 LOC285740 -0.62 -8.31 -0.42 2.53e-15 Hypospadias; CRC cis rs728616 0.558 rs34268041 chr10:82148639 A/G cg11900509 chr10:81946545 ANXA11 -0.56 -6.26 -0.33 1.23e-9 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs684232 0.602 rs448465 chr17:559888 A/T cg15660573 chr17:549704 VPS53 -0.92 -16.58 -0.67 2.73e-45 Prostate cancer; CRC cis rs1448094 0.935 rs11117108 chr12:86322310 T/A cg19622623 chr12:86230825 RASSF9 -0.35 -5.69 -0.3 2.83e-8 Major depressive disorder; CRC cis rs6582630 0.598 rs10880614 chr12:38509766 G/A cg26384229 chr12:38710491 ALG10B -0.52 -7.47 -0.38 7.14e-13 Drug-induced liver injury (flucloxacillin); CRC cis rs7666738 0.785 rs11097614 chr4:99092175 G/C cg05340658 chr4:99064831 C4orf37 0.51 6.33 0.33 7.96e-10 Colonoscopy-negative controls vs population controls; CRC cis rs6424115 0.618 rs10917420 chr1:24062987 C/T cg15997130 chr1:24165203 NA 0.5 7.56 0.38 4.13e-13 Immature fraction of reticulocytes; CRC cis rs13191362 0.935 rs34347104 chr6:163055716 C/T cg06582575 chr6:163149167 PACRG;PARK2 0.93 11.5 0.54 5.69e-26 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs11148252 0.740 rs9526914 chr13:52976300 G/T cg02158880 chr13:53174818 NA 0.44 6.39 0.33 5.73e-10 Lewy body disease; CRC cis rs2251381 0.750 rs2251186 chr21:30528880 G/A cg24692254 chr21:30365293 RNF160 0.76 12.59 0.57 6.24e-30 Selective IgA deficiency; CRC cis rs7072216 0.621 rs3750605 chr10:100175654 C/T cg26618903 chr10:100175079 PYROXD2 -0.51 -7.9 -0.4 4.35e-14 Metabolite levels; CRC cis rs2565722 0.622 rs2465834 chr6:161301868 T/C cg03159191 chr6:161285451 NA -0.46 -6.28 -0.33 1.07e-9 Blood protein levels; CRC cis rs9916302 0.731 rs11868030 chr17:37650332 A/G cg00129232 chr17:37814104 STARD3 -0.54 -8.0 -0.4 2.12e-14 Glomerular filtration rate (creatinine); CRC cis rs2019137 0.936 rs3811059 chr2:113962071 C/T cg19083407 chr2:113993142 PAX8;LOC440839;LOC654433 -0.47 -6.68 -0.35 1.02e-10 Lymphocyte counts; CRC cis rs1348850 0.632 rs4470372 chr2:178505857 G/A cg22681709 chr2:178499509 PDE11A -0.51 -9.47 -0.46 5.45e-19 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs9611565 0.512 rs9607842 chr22:42192722 G/A cg06634786 chr22:41940651 POLR3H -0.69 -7.7 -0.39 1.64e-13 Vitiligo; CRC cis rs2204008 0.692 rs11613378 chr12:38213138 T/A cg13010199 chr12:38710504 ALG10B 0.45 5.74 0.3 2.1e-8 Bladder cancer; CRC cis rs6963495 0.818 rs55825845 chr7:105166713 A/G cg13798780 chr7:105162888 PUS7 0.69 8.2 0.41 5.36e-15 Bipolar disorder (body mass index interaction); CRC cis rs780096 0.526 rs7602534 chr2:27592423 C/T cg27432699 chr2:27873401 GPN1 -0.53 -8.04 -0.41 1.59e-14 Total body bone mineral density; CRC cis rs9786986 0.665 rs12401438 chr1:235701732 C/T cg08848088 chr1:235714526 GNG4 0.52 5.89 0.31 9.54e-9 Body mass index; CRC cis rs8180040 1.000 rs295442 chr3:47335881 A/C cg02527881 chr3:46936655 PTH1R -0.38 -7.12 -0.37 6.9e-12 Colorectal cancer; CRC cis rs868943 0.743 rs4628134 chr6:116360141 A/G cg05304507 chr6:116381966 FRK 0.26 6.03 0.32 4.37e-9 Total cholesterol levels; CRC cis rs853679 0.607 rs200489 chr6:27798257 T/C cg26958806 chr6:27640298 NA 0.65 5.6 0.3 4.48e-8 Depression; CRC cis rs11741688 0.557 rs6600994 chr5:178336005 T/A cg20935368 chr5:178288625 ZNF354B 0.43 7.02 0.36 1.31e-11 Sleep duration; CRC cis rs1800469 1.000 rs1800469 chr19:41860296 A/G cg09537434 chr19:41945824 ATP5SL -0.52 -6.6 -0.34 1.66e-10 Colorectal cancer; CRC cis rs7568458 0.846 rs6738645 chr2:85783128 T/G cg02493740 chr2:85810744 VAMP5 -0.38 -6.08 -0.32 3.38e-9 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); CRC cis rs875971 1.000 rs7789554 chr7:65946038 A/G cg18876405 chr7:65276391 NA 0.52 8.9 0.44 3.86e-17 Aortic root size; CRC cis rs4700695 0.764 rs251301 chr5:65300017 G/C cg21114390 chr5:65439923 SFRS12 0.59 6.61 0.34 1.57e-10 Facial morphology (factor 19); CRC cis rs9916302 0.808 rs12943928 chr17:37611330 G/A cg07936489 chr17:37558343 FBXL20 -0.84 -13.1 -0.59 7.38e-32 Glomerular filtration rate (creatinine); CRC cis rs1552244 0.554 rs2272120 chr3:10046703 C/T cg16606324 chr3:10149918 C3orf24 0.48 7.09 0.36 8.29e-12 Alzheimer's disease; CRC cis rs10979 0.597 rs9399449 chr6:143908376 C/T cg25407410 chr6:143891975 LOC285740 -0.63 -8.38 -0.42 1.51e-15 Hypospadias; CRC cis rs11122272 0.732 rs999010 chr1:231495316 A/G cg06096015 chr1:231504339 EGLN1 0.39 6.02 0.31 4.66e-9 Hemoglobin concentration; CRC cis rs311392 0.554 rs377049 chr8:55097512 A/G cg06042504 chr8:55087323 NA -0.37 -5.77 -0.3 1.79e-8 Pelvic organ prolapse (moderate/severe); CRC cis rs853679 0.517 rs4713145 chr6:28106827 T/C cg03623178 chr6:28175578 NA 0.96 12.57 0.57 7.23e-30 Depression; CRC cis rs1873147 0.569 rs12593531 chr15:63309936 C/G cg12160578 chr15:63334699 TPM1 0.63 7.53 0.38 5.02e-13 Orofacial clefts; CRC cis rs9894429 0.789 rs6565611 chr17:79598319 T/C cg18240062 chr17:79603768 NPLOC4 0.66 11.83 0.55 3.97e-27 Eye color traits; CRC cis rs9311474 0.508 rs4687546 chr3:52605943 T/A cg18099408 chr3:52552593 STAB1 -0.48 -8.3 -0.42 2.81e-15 Electroencephalogram traits; CRC cis rs17092148 0.887 rs6059937 chr20:33186200 G/C cg08999081 chr20:33150536 PIGU 0.5 6.35 0.33 6.96e-10 Neuroticism; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg21870244 chr1:198125992 NEK7 0.45 6.55 0.34 2.22e-10 Intelligence (multi-trait analysis); CRC cis rs2408955 0.521 rs10875749 chr12:48531917 T/A cg24011408 chr12:48396354 COL2A1 -0.44 -6.48 -0.34 3.35e-10 Glycated hemoglobin levels; CRC cis rs9311474 0.607 rs13076398 chr3:52573096 G/A cg07507251 chr3:52567010 NT5DC2 0.49 7.45 0.38 8.12e-13 Electroencephalogram traits; CRC cis rs7178572 0.568 rs12916731 chr15:77507021 C/T cg22256960 chr15:77711686 NA -0.66 -9.54 -0.47 3.38e-19 Type 2 diabetes; CRC cis rs7914558 0.966 rs2297786 chr10:104679978 C/T cg04362960 chr10:104952993 NT5C2 0.6 9.16 0.45 5.82e-18 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs954108 0.809 rs1592059 chr13:29368961 G/A cg11788234 chr13:29393811 NA -0.42 -6.6 -0.34 1.64e-10 Obesity-related traits; CRC cis rs28386778 0.897 rs2727330 chr17:61925498 A/G cg23090583 chr17:61904693 PSMC5;FTSJ3 -1.01 -19.92 -0.74 1.74e-58 Prudent dietary pattern; CRC cis rs7945705 0.967 rs10769970 chr11:8917937 A/G cg14711859 chr11:8959438 ASCL3 -0.51 -8.2 -0.41 5.31e-15 Hemoglobin concentration; CRC cis rs2032447 0.869 rs2230655 chr6:26033506 A/G cg27635394 chr6:26043820 HIST1H2BB -0.45 -6.54 -0.34 2.38e-10 Intelligence (multi-trait analysis); CRC cis rs13256369 0.951 rs13270852 chr8:8566853 A/G cg06671706 chr8:8559999 CLDN23 0.61 8.87 0.44 4.71e-17 Obesity-related traits; CRC cis rs1348850 0.526 rs7607073 chr2:178375065 C/A cg27490568 chr2:178487706 NA 0.62 7.61 0.39 2.95e-13 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs7945718 0.592 rs10765985 chr11:12676468 G/A cg25843174 chr11:12811716 TEAD1 0.39 7.07 0.36 9.43e-12 Educational attainment (years of education); CRC cis rs12540874 0.670 rs3887826 chr7:50544961 G/A cg14593290 chr7:50529359 DDC -0.47 -6.67 -0.35 1.08e-10 Systemic sclerosis; CRC cis rs875971 0.660 rs13224319 chr7:66007363 A/G cg11764359 chr7:65958608 NA 0.54 8.48 0.42 7.53e-16 Aortic root size; CRC cis rs3862030 0.503 rs10786673 chr10:104280537 G/A cg11453585 chr10:104263688 ACTR1A;SUFU 0.91 17.47 0.69 8.43e-49 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for body mass index; CRC cis rs7666738 0.830 rs10017557 chr4:98983969 G/A cg17366294 chr4:99064904 C4orf37 0.43 7.33 0.37 1.76e-12 Colonoscopy-negative controls vs population controls; CRC cis rs3733346 0.553 rs6813110 chr4:942660 C/T cg23939001 chr4:940644 TMEM175 0.73 16.52 0.67 4.49e-45 Sjögren's syndrome; CRC trans rs9393777 0.841 rs34332556 chr6:27357414 C/G cg06606381 chr12:133084897 FBRSL1 -1.15 -7.76 -0.39 1.12e-13 Intelligence (multi-trait analysis); CRC cis rs6963495 0.818 rs73192141 chr7:105201129 T/G cg13798780 chr7:105162888 PUS7 0.64 7.27 0.37 2.7e-12 Bipolar disorder (body mass index interaction); CRC cis rs1799949 1.000 rs8176083 chr17:41275151 G/C cg05368731 chr17:41323189 NBR1 0.65 9.58 0.47 2.53e-19 Menopause (age at onset); CRC cis rs4974559 0.895 rs12646130 chr4:1330530 G/C cg02980000 chr4:1222292 CTBP1 0.74 8.28 0.42 3.18e-15 Systolic blood pressure; CRC cis rs9311676 0.656 rs11718352 chr3:58401480 G/A cg06643156 chr3:58380774 PXK 0.42 6.38 0.33 5.84e-10 Systemic lupus erythematosus; CRC cis rs8180040 0.800 rs6768221 chr3:47296899 C/G cg02527881 chr3:46936655 PTH1R 0.36 6.19 0.32 1.75e-9 Colorectal cancer; CRC cis rs1568889 1.000 rs11826837 chr11:28322566 C/G cg06544937 chr11:28130018 METT5D1;KIF18A -0.75 -10.85 -0.51 1.21e-23 Bipolar disorder; CRC cis rs34779708 0.931 rs35317849 chr10:35285721 C/A cg03585969 chr10:35415529 CREM 0.66 8.8 0.44 7.91e-17 Inflammatory bowel disease;Crohn's disease; CRC cis rs17601876 0.814 rs8038715 chr15:51561120 T/A cg19946085 chr15:51559439 CYP19A1 -0.34 -6.93 -0.36 2.21e-11 Estrone/androstenedione ratio in resected early stage-receptor positive breast cancer; CRC cis rs6763159 1.000 rs1447807 chr3:59648681 A/G cg07069742 chr3:59644285 NA -0.35 -7.13 -0.37 6.34e-12 Conotruncal heart defects; CRC cis rs6502050 0.814 rs9894554 chr17:80073423 C/G cg22110888 chr17:80059540 CCDC57 -0.43 -6.63 -0.34 1.35e-10 Life satisfaction; CRC cis rs2732480 0.517 rs2634676 chr12:48738236 A/G cg04545296 chr12:48745243 ZNF641 0.36 6.19 0.32 1.81e-9 Hemoglobin concentration;Red blood cell count;Hematocrit; CRC cis rs62229266 0.659 rs2835242 chr21:37413532 A/C cg12218747 chr21:37451666 NA -0.36 -6.18 -0.32 1.86e-9 Mitral valve prolapse; CRC cis rs2066819 1.000 rs79824801 chr12:56728137 T/C cg26714650 chr12:56694279 CS -1.41 -11.53 -0.54 4.75e-26 Psoriasis vulgaris; CRC cis rs67478160 0.643 rs11628332 chr14:104241141 C/T cg08213375 chr14:104286397 PPP1R13B 0.65 13.65 0.6 6.38e-34 Schizophrenia; CRC cis rs9903692 0.954 rs12936731 chr17:46128359 G/C cg21215337 chr17:46176117 CBX1 0.43 7.83 0.4 6.68e-14 Pulse pressure; CRC cis rs7727544 0.735 rs2631370 chr5:131703776 T/C cg24060327 chr5:131705240 SLC22A5 0.39 6.25 0.33 1.25e-9 Blood metabolite levels; CRC trans rs11039798 0.660 rs28435129 chr11:48629795 A/T cg03929089 chr4:120376271 NA 0.66 6.99 0.36 1.54e-11 Axial length; CRC cis rs8016982 0.674 rs11159494 chr14:81667611 G/C cg01989461 chr14:81687754 GTF2A1 0.63 10.41 0.5 3.89e-22 Schizophrenia; CRC cis rs6456156 0.716 rs6905876 chr6:167521562 C/T cg07741184 chr6:167504864 NA 0.47 8.12 0.41 9.23e-15 Primary biliary cholangitis; CRC cis rs889398 0.741 rs7192213 chr16:69926280 G/A cg00738113 chr16:70207722 CLEC18C -0.34 -5.81 -0.3 1.49e-8 Body mass index; CRC cis rs28386778 0.897 rs2584624 chr17:61904546 A/G cg06873352 chr17:61820015 STRADA 0.77 14.59 0.63 1.54e-37 Prudent dietary pattern; CRC cis rs6460942 1.000 rs112996286 chr7:12315741 G/C cg20607287 chr7:12443886 VWDE -0.64 -6.41 -0.33 5.11e-10 Coronary artery disease; CRC cis rs7772486 0.754 rs4896832 chr6:145964151 G/A cg13319975 chr6:146136371 FBXO30 -0.46 -6.78 -0.35 5.54e-11 Lobe attachment (rater-scored or self-reported); CRC cis rs4132509 1.000 rs12049228 chr1:243995271 C/A cg21452805 chr1:244014465 NA 0.52 6.9 0.36 2.76e-11 RR interval (heart rate); CRC trans rs208520 0.690 rs12208977 chr6:66725257 G/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 1.05 14.76 0.63 3.56e-38 Exhaled nitric oxide output; CRC cis rs875971 0.545 rs67775320 chr7:65658779 T/C cg11764359 chr7:65958608 NA 0.46 5.96 0.31 6.64e-9 Aortic root size; CRC cis rs1218582 0.710 rs7553195 chr1:154837796 T/C cg24250549 chr1:154909240 PMVK 0.57 9.58 0.47 2.44e-19 Prostate cancer; CRC cis rs9393692 0.557 rs1883213 chr6:26303178 A/C cg13736514 chr6:26305472 NA -0.46 -7.54 -0.38 4.65e-13 Educational attainment; CRC cis rs1862618 0.853 rs33326 chr5:56142601 G/A cg20203395 chr5:56204925 C5orf35 -0.72 -8.55 -0.43 4.67e-16 Initial pursuit acceleration; CRC cis rs17001868 0.614 rs61467436 chr22:40736713 T/C cg07138101 chr22:40742427 ADSL 0.59 7.84 0.4 6.24e-14 Mammographic density (dense area); CRC cis rs12580194 0.593 rs12581916 chr12:55764409 A/C cg23425280 chr12:56401806 NA 0.47 5.7 0.3 2.71e-8 Cancer; CRC cis rs977987 0.737 rs8046697 chr16:75442144 T/C cg03315344 chr16:75512273 CHST6 0.55 9.29 0.46 2.16e-18 Dupuytren's disease; CRC trans rs10504229 0.953 rs72652908 chr8:58191324 G/A cg04077850 chr5:125800366 GRAMD3 0.37 6.27 0.33 1.15e-9 Developmental language disorder (linguistic errors); CRC cis rs898097 0.578 rs6502021 chr17:80907728 T/C cg19046167 chr17:80928561 B3GNTL1 0.46 8.04 0.41 1.64e-14 Breast cancer; CRC cis rs7773004 1.000 rs1155207 chr6:26328365 A/G cg13736514 chr6:26305472 NA -0.41 -6.79 -0.35 5.12e-11 Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for body mass index;Waist circumference adjusted for BMI in non-smokers;Waist circumference adjusted for BMI (adjusted for smoking behaviour); CRC cis rs524281 1.000 rs565198 chr11:65913508 A/T cg14036092 chr11:66035641 RAB1B 0.49 6.65 0.34 1.21e-10 Electroencephalogram traits; CRC cis rs6918586 0.658 rs198843 chr6:26110314 A/T cg18357526 chr6:26021779 HIST1H4A -0.49 -7.4 -0.38 1.16e-12 Schizophrenia; CRC cis rs2075371 0.796 rs1643040 chr7:134011703 G/C cg11752832 chr7:134001865 SLC35B4 0.47 7.02 0.36 1.24e-11 Mean platelet volume; CRC cis rs597539 0.652 rs613128 chr11:68638058 G/T cg06028808 chr11:68637592 NA 0.41 6.67 0.35 1.07e-10 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs3087591 1.000 rs9902893 chr17:29625638 G/A cg24425628 chr17:29625626 OMG;NF1 -0.87 -16.67 -0.68 1.16e-45 Hip circumference; CRC cis rs7613875 0.663 rs6762477 chr3:50093209 G/A cg24110177 chr3:50126178 RBM5 0.54 8.03 0.4 1.78e-14 Body mass index; CRC cis rs9902453 1.000 rs57411618 chr17:28273052 A/G cg26525008 chr17:28256777 EFCAB5;SSH2 0.59 8.98 0.44 2.16e-17 Coffee consumption (cups per day); CRC cis rs4713118 0.662 rs149948 chr6:27974817 C/G cg23161317 chr6:28129485 ZNF389 0.46 6.49 0.34 3.25e-10 Parkinson's disease; CRC cis rs62103177 0.608 rs4799115 chr18:77736365 A/T cg20368463 chr18:77673604 PQLC1 -0.6 -5.89 -0.31 9.33e-9 Opioid sensitivity; CRC trans rs2463822 0.925 rs6863 chr11:62160725 G/T cg14557552 chr3:187012559 NA 0.53 6.0 0.31 5.09e-9 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs8067545 0.586 rs57837691 chr17:20203073 T/C cg13482628 chr17:19912719 NA -0.48 -7.61 -0.39 2.96e-13 Schizophrenia; CRC cis rs61677309 1.000 rs1945765 chr11:118182829 T/A cg06090739 chr11:118230722 UBE4A 0.42 5.72 0.3 2.34e-8 Lung cancer in ever smokers; CRC cis rs4780401 0.609 rs4780399 chr16:11828701 A/T cg01061890 chr16:11836724 TXNDC11 -0.57 -8.2 -0.41 5.44e-15 Rheumatoid arthritis; CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg00983485 chr15:31284262 MTMR10 -0.51 -6.37 -0.33 6.39e-10 Diisocyanate-induced asthma; CRC cis rs7208859 0.673 rs36056619 chr17:29172284 T/C cg14008862 chr17:28927542 LRRC37B2 0.55 5.74 0.3 2.1e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg19091366 chr12:94853648 CCDC41;LOC144486 0.51 7.24 0.37 3.21e-12 Anxiety disorder; CRC cis rs4654899 0.802 rs10737452 chr1:21199764 C/T cg02927042 chr1:21476669 EIF4G3 0.44 6.99 0.36 1.58e-11 Superior frontal gyrus grey matter volume; CRC cis rs780096 0.546 rs1647284 chr2:27608115 C/T cg12000995 chr2:27665139 KRTCAP3 -0.3 -6.17 -0.32 2.03e-9 Total body bone mineral density; CRC cis rs1387259 0.899 rs7307566 chr12:48604682 A/G cg24011408 chr12:48396354 COL2A1 0.44 6.23 0.32 1.44e-9 Obstructive sleep apnea trait (apnea hypopnea index); CRC trans rs6601327 0.540 rs12542912 chr8:9585196 C/T cg06636001 chr8:8085503 FLJ10661 -0.5 -7.32 -0.37 1.97e-12 Multiple myeloma (hyperdiploidy); CRC cis rs7192380 0.639 rs7186296 chr16:69808998 A/G cg04110750 chr16:69646130 NFAT5 0.41 6.19 0.32 1.8e-9 Sjögren's syndrome; CRC cis rs798554 0.797 rs2107964 chr7:2863574 G/A cg14895029 chr7:2775587 GNA12 -0.43 -6.11 -0.32 2.85e-9 Height; CRC cis rs9549260 0.755 rs4941987 chr13:41195992 T/C cg21288729 chr13:41239152 FOXO1 0.42 6.59 0.34 1.8e-10 Red blood cell count; CRC cis rs2836974 0.897 rs2836929 chr21:40543811 T/C cg06238570 chr21:40685208 BRWD1 0.76 10.62 0.51 7.3e-23 Cognitive function; CRC cis rs950027 0.596 rs2467865 chr15:45638307 T/C cg10760299 chr15:45669010 GATM 0.36 5.81 0.31 1.44e-8 Response to fenofibrate (adiponectin levels); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg21283714 chr1:205196967 TMCC2 0.4 6.19 0.32 1.83e-9 Intelligence (multi-trait analysis); CRC cis rs2708977 0.842 rs10209780 chr2:97140142 T/G cg01950434 chr2:97203154 ARID5A -0.4 -5.92 -0.31 8.29e-9 Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes; CRC cis rs6598955 0.543 rs79778574 chr1:26538482 A/G cg04990556 chr1:26633338 UBXN11 0.82 9.53 0.47 3.52e-19 Obesity-related traits; CRC cis rs9926296 0.605 rs886951 chr16:89836865 A/G cg21285383 chr16:89894308 SPIRE2 0.35 5.85 0.31 1.18e-8 Vitiligo; CRC trans rs9929218 0.954 rs2059254 chr16:68817439 C/T cg04657470 chr2:198365150 HSPE1;HSPD1 -0.77 -10.74 -0.51 2.94e-23 Colorectal cancer; CRC cis rs79349575 0.783 rs15563 chr17:47005193 A/G cg00947319 chr17:47005597 UBE2Z -0.35 -6.17 -0.32 2e-9 Type 2 diabetes; CRC cis rs881375 0.967 rs7848332 chr9:123669496 T/C cg14255062 chr9:123606675 PSMD5;LOC253039 0.42 6.06 0.32 3.7e-9 Rheumatoid arthritis; CRC cis rs9462027 0.628 rs2038839 chr6:34777791 A/G cg07306190 chr6:34760872 UHRF1BP1 -0.34 -5.93 -0.31 7.48e-9 Systemic lupus erythematosus; CRC cis rs6860806 0.507 rs273917 chr5:131659618 A/G cg18301423 chr5:131593218 PDLIM4 0.39 6.42 0.33 4.65e-10 Breast cancer; CRC cis rs4604732 0.536 rs4433437 chr1:247636580 A/T cg12758973 chr1:247694275 LOC148824;OR2C3 0.44 6.52 0.34 2.72e-10 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CRC cis rs4975616 0.869 rs465498 chr5:1325803 A/G cg06550200 chr5:1325588 CLPTM1L -0.74 -11.97 -0.55 1.16e-27 Lung cancer; CRC cis rs644799 0.965 rs3789960 chr11:95509037 C/G cg03916912 chr11:95522834 CEP57;FAM76B 0.96 17.82 0.7 3.44e-50 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs13118159 0.509 rs7688922 chr4:1361011 T/C cg19318889 chr4:1322082 MAEA 0.71 10.43 0.5 3.4e-22 Longevity; CRC trans rs951252 0.504 rs11734405 chr4:146081096 C/T cg27665823 chr16:460516 DECR2 -0.45 -6.18 -0.32 1.91e-9 Hip circumference; CRC cis rs4665809 1.000 rs6546766 chr2:26328680 T/C cg26119090 chr2:26468346 HADHA;HADHB -0.6 -7.61 -0.39 3e-13 Gut microbiome composition (summer); CRC cis rs703842 1.000 rs2072052 chr12:58146719 A/C cg04478727 chr12:58166393 METTL1;FAM119B 0.43 5.64 0.3 3.7e-8 Multiple sclerosis; CRC cis rs11723261 0.621 rs7440274 chr4:155713 C/T cg12746427 chr4:53362 ZNF718;ZNF595 -0.46 -6.15 -0.32 2.24e-9 Immune response to smallpox vaccine (IL-6); CRC cis rs6951245 1.000 rs79443843 chr7:1075245 G/A cg04025307 chr7:1156635 C7orf50 0.63 6.73 0.35 7.63e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs9381040 0.655 rs2294695 chr6:41036770 A/G cg09580153 chr6:41068724 NFYA;LOC221442 -0.4 -5.77 -0.3 1.84e-8 Alzheimer's disease (late onset); CRC cis rs2019137 0.936 rs2241978 chr2:113954006 A/G cg12889195 chr2:113992843 PAX8;LOC440839;LOC654433 -0.51 -7.36 -0.38 1.5e-12 Lymphocyte counts; CRC cis rs600806 0.850 rs10745354 chr1:109931908 C/T cg23032129 chr1:109941072 SORT1 -0.28 -6.06 -0.32 3.68e-9 Intelligence (multi-trait analysis); CRC cis rs8141797 0.792 rs12484557 chr22:24555861 A/G cg20894457 chr22:24584366 SUSD2 0.63 6.09 0.32 3.22e-9 Amyotrophic lateral sclerosis;Coronary artery disease; CRC cis rs12701220 0.948 rs12690826 chr7:1081618 A/G cg00990874 chr7:1149470 C7orf50 -0.51 -5.97 -0.31 6.15e-9 Bronchopulmonary dysplasia; CRC cis rs11155671 0.530 rs2342769 chr6:150216507 T/C cg07701084 chr6:150067640 NUP43 0.54 7.65 0.39 2.22e-13 Testicular germ cell tumor; CRC cis rs990171 1.000 rs6543141 chr2:103076351 G/A cg03938978 chr2:103052716 IL18RAP 0.46 5.89 0.31 9.34e-9 Lymphocyte counts; CRC cis rs10046574 0.561 rs7789858 chr7:135212285 A/G cg27474649 chr7:135195673 CNOT4 0.61 5.95 0.31 7.03e-9 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs782590 0.837 rs2627769 chr2:55927288 G/C cg18811423 chr2:55921094 PNPT1 0.9 17.61 0.7 2.32e-49 Metabolic syndrome; CRC cis rs7726839 0.540 rs28364691 chr5:664084 G/A cg14541582 chr5:601475 NA -0.34 -6.46 -0.34 3.71e-10 Obesity-related traits; CRC cis rs4713118 0.739 rs2893931 chr6:27748010 G/A cg21251018 chr6:28226885 NKAPL 0.42 6.06 0.32 3.81e-9 Parkinson's disease; CRC cis rs9517320 0.534 rs9554477 chr13:99160379 C/T cg07423050 chr13:99094983 FARP1 -0.5 -7.42 -0.38 9.89e-13 Longevity; CRC cis rs9733 0.596 rs6669369 chr1:150695892 C/T cg17724175 chr1:150552817 MCL1 0.57 9.12 0.45 7.76e-18 Tonsillectomy; CRC cis rs780096 0.526 rs10182937 chr2:27651693 T/C cg12000995 chr2:27665139 KRTCAP3 -0.31 -6.48 -0.34 3.29e-10 Total body bone mineral density; CRC cis rs3785574 0.924 rs2584641 chr17:61862889 A/G cg11494091 chr17:61959527 GH2 0.38 5.93 0.31 7.87e-9 Height; CRC cis rs4757319 0.515 rs4757316 chr11:15432094 A/G cg03245590 chr11:15329459 NA 0.53 9.27 0.46 2.49e-18 Breast cancer; CRC cis rs7103648 0.864 rs10742802 chr11:47432725 T/G cg20307385 chr11:47447363 PSMC3 0.99 18.32 0.71 3.48e-52 Diastolic blood pressure;Systolic blood pressure; CRC cis rs17376456 0.877 rs2290937 chr5:93356515 A/T cg25358565 chr5:93447407 FAM172A 0.96 10.71 0.51 3.72e-23 Diabetic retinopathy; CRC cis rs561341 1.000 rs72823789 chr17:30284084 G/A cg19193384 chr17:30244184 NA -0.65 -7.5 -0.38 6.06e-13 Hip circumference adjusted for BMI; CRC cis rs55788414 0.932 rs9929066 chr16:81182157 G/A cg06400318 chr16:81190750 PKD1L2 -0.59 -6.78 -0.35 5.73e-11 Left ventricular obstructive tract defect (maternal effect); CRC cis rs10493773 0.609 rs2389972 chr1:86190666 A/G cg00734567 chr1:86172782 ZNHIT6 -0.44 -6.74 -0.35 6.92e-11 Urate levels in overweight individuals; CRC cis rs9549260 0.620 rs4325427 chr13:41216534 C/T cg21288729 chr13:41239152 FOXO1 0.5 7.92 0.4 3.77e-14 Red blood cell count; CRC cis rs4253772 0.744 rs1134224 chr22:46633371 A/T cg09491104 chr22:46646882 C22orf40 -0.44 -6.93 -0.36 2.19e-11 LDL cholesterol;Cholesterol, total; CRC trans rs2797369 0.769 rs12199600 chr6:101594847 C/T cg26346621 chr12:6873348 NA 0.39 6.15 0.32 2.19e-9 Renal function-related traits (eGRFcrea); CRC cis rs7618501 0.966 rs13085679 chr3:49869631 G/A cg24308560 chr3:49941425 MST1R -0.48 -7.5 -0.38 5.97e-13 Intelligence (multi-trait analysis); CRC cis rs6089584 0.816 rs4925336 chr20:60627180 A/G cg06108461 chr20:60628389 TAF4 -0.9 -15.66 -0.65 1.12e-41 Body mass index; CRC cis rs28386778 0.734 rs12946669 chr17:62006007 A/G cg22520471 chr17:61851767 DDX42;CCDC47 0.56 8.36 0.42 1.85e-15 Prudent dietary pattern; CRC cis rs5417 0.775 rs222852 chr17:7140606 A/G cg25256661 chr17:7137939 DVL2 0.7 12.49 0.57 1.45e-29 Diastolic blood pressure; CRC cis rs6815814 0.768 rs6835514 chr4:38894380 C/T cg06935464 chr4:38784597 TLR10 -0.62 -8.08 -0.41 1.21e-14 Breast cancer; CRC cis rs7809950 0.723 rs62483633 chr7:106876644 T/G cg23024343 chr7:107201750 COG5 -0.73 -10.04 -0.48 7.16e-21 Coronary artery disease; CRC cis rs7552404 1.000 rs4949872 chr1:76131392 C/G cg10523679 chr1:76189770 ACADM 0.82 11.28 0.53 3.49e-25 Blood metabolite levels;Acylcarnitine levels; CRC cis rs6495122 0.532 rs2470890 chr15:75047426 C/T cg14664628 chr15:75095509 CSK -0.55 -8.48 -0.42 7.64e-16 Caffeine consumption;Diastolic blood pressure;Coffee consumption; CRC cis rs62103177 0.733 rs62096747 chr18:77619568 A/G cg00383167 chr18:77616694 NA 0.54 6.02 0.31 4.69e-9 Opioid sensitivity; CRC cis rs1697139 0.583 rs17289614 chr5:66541592 G/A cg16691251 chr5:66510806 NA 0.42 7.36 0.38 1.53e-12 Breast cancer; CRC cis rs4664293 0.836 rs13032500 chr2:160606251 G/C cg08347373 chr2:160653686 CD302 -0.47 -7.43 -0.38 9.57e-13 Monocyte percentage of white cells; CRC cis rs4332037 0.506 rs62442924 chr7:1989976 C/T cg23422044 chr7:1970798 MAD1L1 -0.55 -6.83 -0.35 4.07e-11 Bipolar disorder; CRC cis rs1348850 0.514 rs4893974 chr2:178497026 A/G cg27490568 chr2:178487706 NA 0.54 7.43 0.38 9.47e-13 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs1801251 1.000 rs6745879 chr2:233590007 A/G cg25237894 chr2:233734115 C2orf82 0.54 8.76 0.43 1.09e-16 Coronary artery disease; CRC cis rs56146971 0.763 rs2064961 chr14:91868814 A/G cg16433844 chr14:91963127 SMEK1 -0.62 -6.61 -0.34 1.59e-10 Alzheimer disease and age of onset; CRC cis rs7552404 0.924 rs2173378 chr1:76201992 G/T cg03433033 chr1:76189801 ACADM 0.74 11.25 0.53 4.8e-25 Blood metabolite levels;Acylcarnitine levels; CRC cis rs7829975 0.688 rs13270194 chr8:8378102 T/C cg08975724 chr8:8085496 FLJ10661 0.38 5.66 0.3 3.25e-8 Mood instability; CRC cis rs597539 0.652 rs667989 chr11:68685776 T/A cg06028808 chr11:68637592 NA 0.4 6.21 0.32 1.62e-9 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs10504229 1.000 rs6989060 chr8:58178989 T/G cg02290350 chr8:58132656 NA -0.42 -5.96 -0.31 6.62e-9 Developmental language disorder (linguistic errors); CRC cis rs2688608 0.620 rs7080350 chr10:75577843 A/G cg16540259 chr10:75572220 NDST2 -0.39 -6.24 -0.33 1.37e-9 Inflammatory bowel disease; CRC cis rs1707322 1.000 rs34446427 chr1:46417655 A/C cg03146154 chr1:46216737 IPP 0.51 7.12 0.37 6.96e-12 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs6961069 0.773 rs1761661 chr7:80238041 A/C cg04458919 chr7:80252533 CD36 -0.34 -6.18 -0.32 1.85e-9 Platelet count; CRC cis rs4853012 0.941 rs4852329 chr2:74354544 A/G cg05890377 chr2:74357713 NA 0.67 10.11 0.49 4.05e-21 Gestational age at birth (maternal effect); CRC trans rs853679 0.760 rs11962305 chr6:28199937 G/C cg06606381 chr12:133084897 FBRSL1 -0.65 -6.65 -0.34 1.22e-10 Depression; CRC cis rs2836950 0.520 rs1980407 chr21:40543961 T/C cg11644478 chr21:40555479 PSMG1 -0.52 -7.87 -0.4 5.16e-14 Menarche (age at onset); CRC cis rs4363385 0.747 rs4845334 chr1:152982998 T/A cg25856811 chr1:152973957 SPRR3 -0.25 -6.85 -0.35 3.56e-11 Inflammatory skin disease; CRC cis rs7659604 0.791 rs57316471 chr4:122663939 A/G cg20573242 chr4:122745356 CCNA2 0.44 6.52 0.34 2.59e-10 Type 2 diabetes; CRC cis rs1552244 0.572 rs68013239 chr3:10165711 G/T cg13047869 chr3:10149882 C3orf24 0.54 6.49 0.34 3.1e-10 Alzheimer's disease; CRC cis rs921968 0.643 rs2278529 chr2:219502132 C/T cg02176678 chr2:219576539 TTLL4 0.49 8.07 0.41 1.29e-14 Mean corpuscular hemoglobin concentration; CRC trans rs9467711 1.000 rs9467704 chr6:26319486 A/G cg15845792 chr6:28175446 NA -0.64 -6.13 -0.32 2.45e-9 Autism spectrum disorder or schizophrenia; CRC cis rs6912958 0.781 rs985764 chr6:88215206 G/A cg12350822 chr6:88032061 C6orf162;GJB7 -0.34 -6.4 -0.33 5.39e-10 Monocyte percentage of white cells; CRC cis rs7191700 0.601 rs243329 chr16:11352313 A/T cg00044050 chr16:11439710 C16orf75 0.53 7.69 0.39 1.72e-13 Multiple sclerosis; CRC cis rs7524258 0.903 rs6577424 chr1:7292417 C/T cg07173049 chr1:7289937 CAMTA1 -0.66 -10.84 -0.51 1.31e-23 Tourette's syndrome or obsessive-compulsive disorder; CRC cis rs1129187 0.967 rs6941212 chr6:42915920 A/G cg05552183 chr6:42928497 GNMT 0.61 9.68 0.47 1.19e-19 Alzheimer's disease in APOE e4+ carriers; CRC cis rs5753618 0.583 rs5753601 chr22:31798259 G/T cg22777020 chr22:31556080 RNF185 0.53 6.27 0.33 1.11e-9 Colorectal cancer; CRC trans rs10982213 0.830 rs2274163 chr9:117188714 C/T cg07811750 chr17:4890503 CAMTA2 0.46 7.24 0.37 3.11e-12 Interleukin-6 levels; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg06636527 chr1:144932473 PDE4DIP 0.44 6.19 0.32 1.76e-9 Anxiety disorder; CRC cis rs501120 0.929 rs2576355 chr10:44750362 A/G cg09554077 chr10:44749378 NA 0.89 13.17 0.59 4.18e-32 Coronary artery disease;Coronary heart disease; CRC cis rs10540 1.000 rs12794284 chr11:477623 C/T cg19913688 chr11:428466 ANO9 -0.73 -7.65 -0.39 2.19e-13 Body mass index; CRC cis rs972578 0.936 rs738394 chr22:43366896 C/T cg01576275 chr22:43409880 NA -0.45 -7.27 -0.37 2.62e-12 Mean platelet volume; CRC cis rs6502050 0.835 rs10163485 chr17:80110750 C/T cg19223190 chr17:80058835 NA 0.4 6.36 0.33 6.88e-10 Life satisfaction; CRC cis rs12477438 0.520 rs11678456 chr2:99708237 G/A cg26064155 chr2:99771622 LIPT1;TSGA10 0.83 14.7 0.63 6.15e-38 Chronic sinus infection; CRC cis rs10992471 0.756 rs10992319 chr9:95127895 G/A cg13798575 chr9:95087839 CENPP;NOL8 -0.49 -6.99 -0.36 1.55e-11 Visceral adipose tissue/subcutaneous adipose tissue ratio; CRC cis rs7178572 0.889 rs7171448 chr15:77832316 C/G cg22256960 chr15:77711686 NA -0.61 -9.03 -0.45 1.48e-17 Type 2 diabetes; CRC trans rs6693295 0.605 rs4396095 chr1:246213270 A/G cg03680032 chr11:94965610 SESN3 0.53 6.57 0.34 2e-10 Migraine - clinic-based;Migraine with aura; CRC cis rs6504950 0.720 rs2877634 chr17:52987545 A/G cg26251398 chr17:52985966 TOM1L1 0.37 5.66 0.3 3.33e-8 Breast cancer; CRC cis rs9443645 0.901 rs6454092 chr6:79701972 G/A cg09184832 chr6:79620586 NA -0.5 -9.12 -0.45 7.58e-18 Intelligence (multi-trait analysis); CRC cis rs11098499 0.691 rs10010355 chr4:120261043 A/G cg09307838 chr4:120376055 NA 0.6 9.53 0.46 3.71e-19 Corneal astigmatism; CRC cis rs7705042 0.828 rs1835966 chr5:141501508 C/T cg07392085 chr5:141489673 NDFIP1 0.47 7.37 0.38 1.41e-12 Asthma; CRC cis rs1218582 0.772 rs877343 chr1:154910012 A/G cg03351412 chr1:154909251 PMVK 0.54 8.65 0.43 2.28e-16 Prostate cancer; CRC cis rs17152411 0.947 rs61873270 chr10:126595923 C/A cg07906193 chr10:126599966 NA 0.58 6.52 0.34 2.69e-10 Height; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg13909412 chr9:125703662 RABGAP1 0.47 6.56 0.34 2.03e-10 Response to antipsychotic treatment; CRC cis rs3751196 0.901 rs55932227 chr12:104193086 T/C cg02344784 chr12:104178138 NT5DC3 0.7 7.21 0.37 3.83e-12 Sense of smell; CRC cis rs7312933 0.558 rs11181467 chr12:42765250 C/T cg19980929 chr12:42632907 YAF2 0.42 6.29 0.33 1.04e-9 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CRC cis rs9788682 0.947 rs12439240 chr15:78829091 T/C cg06917634 chr15:78832804 PSMA4 -0.45 -5.61 -0.3 4.26e-8 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; CRC cis rs6500395 0.928 rs723807 chr16:48691443 A/G cg04672837 chr16:48644449 N4BP1 -0.45 -6.63 -0.34 1.38e-10 Response to tocilizumab in rheumatoid arthritis; CRC cis rs79387448 0.564 rs77375846 chr2:103155075 T/C cg00507830 chr2:103233733 NA 0.68 6.58 0.34 1.85e-10 Gut microbiota (bacterial taxa); CRC cis rs6570726 0.902 rs406979 chr6:145838983 G/T cg05347473 chr6:146136440 FBXO30 0.36 5.7 0.3 2.73e-8 Lobe attachment (rater-scored or self-reported); CRC cis rs908922 0.651 rs11205035 chr1:152532832 A/G cg23254163 chr1:152506842 NA 0.49 9.71 0.47 8.86e-20 Hair morphology; CRC cis rs35146811 0.700 rs4729579 chr7:99780282 C/G cg00553149 chr7:99775558 STAG3;GPC2 0.24 5.9 0.31 8.81e-9 Coronary artery disease; CRC trans rs11098499 0.909 rs28668716 chr4:120309875 T/C cg25214090 chr10:38739885 LOC399744 0.63 9.83 0.48 3.61e-20 Corneal astigmatism; CRC cis rs853679 0.527 rs853693 chr6:28282648 C/T cg03623178 chr6:28175578 NA 0.46 6.47 0.34 3.65e-10 Depression; CRC cis rs881375 0.678 rs2416804 chr9:123676396 C/G cg09586646 chr9:123605570 PSMD5;LOC253039 -0.44 -6.52 -0.34 2.58e-10 Rheumatoid arthritis; CRC cis rs1943345 1.000 rs1943345 chr11:82876270 G/T cg07047830 chr11:82868014 PCF11 -0.54 -6.91 -0.36 2.6e-11 Obesity-related traits; CRC cis rs853679 0.550 rs1225599 chr6:28165190 C/T cg25164649 chr6:28176230 NA 0.79 11.08 0.52 1.9e-24 Depression; CRC cis rs847577 0.722 rs1013886 chr7:97709861 A/G cg21770322 chr7:97807741 LMTK2 -0.82 -17.97 -0.7 8.33e-51 Breast cancer; CRC cis rs7772486 0.754 rs9390358 chr6:146145678 C/T cg13319975 chr6:146136371 FBXO30 -0.44 -6.6 -0.34 1.64e-10 Lobe attachment (rater-scored or self-reported); CRC cis rs7173389 1.000 rs7172808 chr15:73663632 A/G cg01796676 chr15:73680284 NA 0.51 6.84 0.35 3.86e-11 Resting heart rate; CRC cis rs9914988 0.778 rs9907192 chr17:27122426 C/G cg12682573 chr17:27188876 MIR451;MIR144 0.58 7.99 0.4 2.37e-14 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs1670533 1.000 rs2045069 chr4:1052206 T/C cg27284194 chr4:1044797 NA 0.5 6.23 0.32 1.43e-9 Recombination rate (females); CRC cis rs7493 0.755 rs17886036 chr7:94987727 C/A cg20119798 chr7:94954144 PON1 -0.45 -5.67 -0.3 3.18e-8 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs897984 0.542 rs11864806 chr16:31095204 G/C cg00531865 chr16:30841666 NA -0.42 -6.09 -0.32 3.15e-9 Dementia with Lewy bodies; CRC cis rs4481887 1.000 rs10736378 chr1:248455769 T/G cg00666640 chr1:248458726 OR2T12 0.53 9.53 0.47 3.48e-19 Common traits (Other); CRC cis rs4474465 0.688 rs4944210 chr11:78282878 C/T cg27205649 chr11:78285834 NARS2 0.54 6.94 0.36 2.04e-11 Alzheimer's disease (survival time); CRC cis rs6662572 0.737 rs9429184 chr1:46524739 G/A cg08644498 chr1:46502608 NA 0.46 7.32 0.37 1.96e-12 Blood protein levels; CRC cis rs1707322 0.963 rs4459051 chr1:46451203 A/G cg06784218 chr1:46089804 CCDC17 0.51 8.96 0.44 2.39e-17 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs4631830 0.720 rs2611475 chr10:51503178 G/A cg20129853 chr10:51489980 NA -0.42 -7.03 -0.36 1.21e-11 Prostate-specific antigen levels; CRC cis rs728616 0.867 rs4520539 chr10:81740529 C/G cg11900509 chr10:81946545 ANXA11 -0.68 -6.82 -0.35 4.39e-11 Chronic obstructive pulmonary disease-related biomarkers; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg08877624 chr8:141521446 CHRAC1 0.38 6.24 0.33 1.31e-9 Liver disease severity in Alagille syndrome; CRC cis rs2976388 0.647 rs2244163 chr8:143784500 T/G cg24046110 chr8:143859143 LYNX1 0.46 7.99 0.4 2.24e-14 Urinary tract infection frequency; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg02951344 chr11:85522279 SYTL2 0.36 6.2 0.32 1.66e-9 Liver disease severity in Alagille syndrome; CRC cis rs2067615 0.560 rs2044304 chr12:107184363 T/G cg13491945 chr12:107078410 RFX4 0.35 6.04 0.32 4.23e-9 Heart rate; CRC cis rs10045504 0.502 rs72746038 chr5:38753999 G/A cg15396434 chr5:38725168 NA -0.61 -6.15 -0.32 2.24e-9 Night sleep phenotypes; CRC cis rs644148 0.872 rs2686780 chr19:44974126 G/C cg15540054 chr19:45004280 ZNF180 -0.55 -7.1 -0.36 7.5e-12 Personality dimensions; CRC trans rs1997103 1.000 rs6958022 chr7:55397389 G/A cg20935933 chr6:143382018 AIG1 0.52 6.72 0.35 7.9e-11 QRS interval (sulfonylurea treatment interaction); CRC cis rs2742417 0.603 rs2742448 chr3:45764246 C/T cg04837898 chr3:45731254 SACM1L 0.38 5.65 0.3 3.56e-8 Response to anti-depressant treatment in major depressive disorder; CRC cis rs896854 0.530 rs10956934 chr8:95992473 C/A cg09323728 chr8:95962352 TP53INP1 -0.42 -6.86 -0.35 3.35e-11 Type 2 diabetes; CRC trans rs208520 0.690 rs2208442 chr6:66867004 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.05 -14.8 -0.63 2.42e-38 Exhaled nitric oxide output; CRC cis rs7550918 1 rs7550918 chr1:247675559 C/T cg11166453 chr1:247681781 NA -0.49 -8.97 -0.44 2.3e-17 Platelet count; CRC cis rs4665809 1.000 rs4665298 chr2:26256378 G/A cg22920501 chr2:26401640 FAM59B -0.5 -6.85 -0.35 3.72e-11 Gut microbiome composition (summer); CRC cis rs4819052 0.851 rs3673 chr21:46681775 C/T cg19498844 chr21:46707878 POFUT2;LOC642852 0.69 9.96 0.48 1.37e-20 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs7223966 1.000 rs8078462 chr17:61857937 T/G cg23090583 chr17:61904693 PSMC5;FTSJ3 0.51 6.27 0.33 1.16e-9 Hip circumference adjusted for BMI;Body mass index; CRC cis rs7412746 0.658 rs10305714 chr1:150800655 C/T cg18016565 chr1:150552671 MCL1 -0.43 -6.05 -0.32 3.98e-9 Melanoma; CRC cis rs17209837 1.000 rs2072383 chr7:87081349 A/G cg00919237 chr7:87102261 ABCB4 -0.48 -5.73 -0.3 2.31e-8 Gallbladder cancer; CRC trans rs2303319 0.504 rs56145818 chr2:162403778 G/A cg27113153 chr11:123612418 ZNF202 -0.72 -6.15 -0.32 2.25e-9 Cognitive function; CRC cis rs11758351 0.660 rs75156165 chr6:26235699 C/A cg10723962 chr6:26240782 HIST1H4F -0.39 -6.14 -0.32 2.44e-9 Gout;Renal underexcretion gout; CRC cis rs4332037 0.851 rs1403175 chr7:1964357 A/T cg21155852 chr7:2048760 MAD1L1 0.45 6.23 0.32 1.42e-9 Bipolar disorder; CRC trans rs877282 0.838 rs11253373 chr10:774857 A/G cg22713356 chr15:30763199 NA 1.28 16.24 0.67 5.85e-44 Uric acid levels; CRC cis rs1448094 0.845 rs7966131 chr12:86350633 T/G cg25456477 chr12:86230367 RASSF9 0.34 5.68 0.3 2.94e-8 Major depressive disorder; CRC cis rs780096 0.526 rs13472 chr2:27600239 G/A cg12000995 chr2:27665139 KRTCAP3 -0.3 -6.03 -0.32 4.35e-9 Total body bone mineral density; CRC cis rs3796619 1.000 rs1466215 chr4:1072220 C/T cg11579758 chr4:1086637 RNF212 0.41 6.65 0.34 1.19e-10 Recombination rate (males); CRC cis rs6495122 0.501 rs7167261 chr15:75343807 T/C cg17294928 chr15:75287854 SCAMP5 -0.43 -6.39 -0.33 5.71e-10 Caffeine consumption;Diastolic blood pressure;Coffee consumption; CRC cis rs7959452 0.719 rs57954211 chr12:69748397 C/A cg22834771 chr12:69754056 YEATS4 -0.5 -7.23 -0.37 3.31e-12 Blood protein levels; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg00252654 chr19:36980732 ZNF566 0.43 6.07 0.32 3.51e-9 Response to antipsychotic treatment; CRC cis rs910316 1.000 rs11845639 chr14:75570293 C/T cg11812906 chr14:75593930 NEK9 0.59 9.46 0.46 6.13e-19 Height; CRC trans rs7615952 0.512 rs4679430 chr3:125357893 T/C cg07211511 chr3:129823064 LOC729375 -0.63 -8.76 -0.43 1.03e-16 Blood pressure (smoking interaction); CRC cis rs9308731 0.623 rs2241844 chr2:111879364 C/T cg04202892 chr2:111875749 ACOXL 0.46 7.54 0.38 4.63e-13 Chronic lymphocytic leukemia; CRC cis rs10256972 0.552 rs2949195 chr7:1202705 G/A cg09177884 chr7:1199841 ZFAND2A -0.51 -7.53 -0.38 4.89e-13 Longevity;Endometriosis; CRC cis rs8044995 0.563 rs3785113 chr16:68369213 T/C cg05110241 chr16:68378359 PRMT7 -0.74 -7.76 -0.39 1.06e-13 Schizophrenia; CRC cis rs4972806 0.814 rs6710370 chr2:177045969 T/C cg14324370 chr2:177042789 NA 0.79 12.99 0.58 1.91e-31 IgG glycosylation; CRC cis rs9398803 0.865 rs1120786 chr6:126808637 T/G cg19875578 chr6:126661172 C6orf173 0.42 5.86 0.31 1.15e-8 Male-pattern baldness; CRC cis rs11098499 0.954 rs17005535 chr4:120411562 C/T cg24375607 chr4:120327624 NA 0.49 7.61 0.39 2.96e-13 Corneal astigmatism; CRC cis rs6963495 0.745 rs56239334 chr7:105165351 G/A cg13798780 chr7:105162888 PUS7 0.69 8.2 0.41 5.36e-15 Bipolar disorder (body mass index interaction); CRC cis rs798554 0.797 rs1182183 chr7:2873136 C/T cg19717773 chr7:2847554 GNA12 -0.49 -7.08 -0.36 8.79e-12 Height; CRC cis rs4481887 0.741 rs6681758 chr1:248540413 T/A cg00666640 chr1:248458726 OR2T12 0.41 7.5 0.38 5.96e-13 Common traits (Other); CRC cis rs2836974 0.666 rs35182074 chr21:40685284 A/C cg11644478 chr21:40555479 PSMG1 -0.67 -10.33 -0.49 7.74e-22 Cognitive function; CRC cis rs4731207 0.596 rs10274820 chr7:124629664 G/A cg23710748 chr7:124431027 NA -0.38 -6.16 -0.32 2.16e-9 Cutaneous malignant melanoma; CRC cis rs11750568 1.000 rs11750568 chr5:178535713 A/G cg10208897 chr5:178548229 ADAMTS2 0.35 5.63 0.3 3.9e-8 Height; CRC cis rs2204008 0.641 rs66876045 chr12:38205713 G/A cg13010199 chr12:38710504 ALG10B 0.45 5.72 0.3 2.37e-8 Bladder cancer; CRC trans rs8002861 0.967 rs7984393 chr13:44484361 T/C cg17145862 chr1:211918768 LPGAT1 0.77 15.89 0.66 1.3e-42 Leprosy; CRC trans rs2727020 0.558 rs1164675 chr11:49325972 C/T cg15704280 chr7:45808275 SEPT13 0.84 13.32 0.59 1.18e-32 Coronary artery disease; CRC cis rs950169 0.922 rs8037078 chr15:84818871 A/G cg11189052 chr15:85197271 WDR73 -0.63 -8.98 -0.44 2.21e-17 Schizophrenia; CRC cis rs2034088 0.965 rs4968070 chr17:446162 A/G cg13332499 chr17:408570 NA 0.41 8.45 0.42 9.5e-16 Hip circumference adjusted for BMI; CRC cis rs10751667 0.600 rs10902266 chr11:1005697 G/T ch.11.42038R chr11:967971 AP2A2 0.58 9.03 0.45 1.53e-17 Alzheimer's disease (late onset); CRC cis rs7085104 0.700 rs7096183 chr10:104609466 T/C cg08772003 chr10:104629869 AS3MT -0.35 -6.01 -0.31 5.05e-9 Immature fraction of reticulocytes;Schizophrenia; CRC cis rs6728642 0.908 rs6576996 chr2:97623312 T/C cg26665480 chr2:98280029 ACTR1B -0.5 -5.89 -0.31 9.34e-9 Bipolar disorder lithium response (continuous) or schizophrenia; CRC cis rs2070488 0.965 rs1870915 chr3:38494228 G/C cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.93 17.67 0.7 1.39e-49 Electrocardiographic conduction measures; CRC cis rs4654899 0.965 rs4654898 chr1:21376383 T/C cg02927042 chr1:21476669 EIF4G3 -0.47 -7.49 -0.38 6.22e-13 Superior frontal gyrus grey matter volume; CRC cis rs6951245 1.000 rs78143408 chr7:1096846 G/A cg22907277 chr7:1156413 C7orf50 0.72 7.6 0.39 3.1400000000000003e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs2882667 0.858 rs6882112 chr5:138413735 C/T cg04439458 chr5:138467593 SIL1 0.32 5.61 0.3 4.22e-8 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs12142240 0.698 rs41294476 chr1:46818374 C/A cg14993813 chr1:46806288 NSUN4 -0.48 -6.15 -0.32 2.24e-9 Menopause (age at onset); CRC cis rs1670533 1.000 rs6827357 chr4:1059202 A/C cg16405210 chr4:1374714 KIAA1530 -0.48 -5.68 -0.3 2.9e-8 Recombination rate (females); CRC cis rs5769765 0.862 rs138856 chr22:50199378 G/T cg02269571 chr22:50332266 NA -0.64 -8.62 -0.43 2.89e-16 Schizophrenia; CRC cis rs728616 0.867 rs12412257 chr10:81729603 C/T cg11900509 chr10:81946545 ANXA11 -0.65 -6.57 -0.34 1.94e-10 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs9467711 0.651 rs72834677 chr6:26106604 C/A cg08501292 chr6:25962987 TRIM38 0.94 8.44 0.42 1.05e-15 Autism spectrum disorder or schizophrenia; CRC cis rs10242455 0.571 rs28365067 chr7:99272310 G/A cg18809830 chr7:99032528 PTCD1 -1.12 -8.14 -0.41 7.97e-15 Blood metabolite levels; CRC cis rs6088590 1.000 rs2236270 chr20:33523155 G/T cg08999081 chr20:33150536 PIGU 0.5 8.39 0.42 1.5e-15 Coronary artery disease; CRC cis rs1048238 0.818 rs945421 chr1:16345393 T/C cg10494257 chr1:16342123 HSPB7 0.39 5.65 0.3 3.54e-8 Systolic blood pressure; CRC cis rs7119 0.651 rs12917431 chr15:77850184 C/G cg10437265 chr15:77819839 NA 0.64 11.28 0.53 3.67e-25 Type 2 diabetes; CRC trans rs1005277 0.579 rs2474594 chr10:38426661 G/C cg17830980 chr10:43048298 ZNF37B -0.59 -9.83 -0.48 3.8e-20 Extrinsic epigenetic age acceleration; CRC cis rs3823572 0.525 rs2002866 chr7:133690378 C/T cg03336402 chr7:133662267 EXOC4 0.67 9.81 0.48 4.3e-20 Intelligence (multi-trait analysis); CRC cis rs4665809 0.549 rs7577896 chr2:26524493 C/T cg27170947 chr2:26402098 FAM59B 0.61 7.28 0.37 2.49e-12 Gut microbiome composition (summer); CRC cis rs947211 1.000 rs1775151 chr1:205745684 C/T cg07157834 chr1:205819609 PM20D1 0.42 5.69 0.3 2.84e-8 Parkinson's disease; CRC cis rs11190604 1.000 rs10883507 chr10:102291275 C/T cg16342193 chr10:102329863 NA -0.36 -5.94 -0.31 7.21e-9 Palmitoleic acid (16:1n-7) levels; CRC cis rs116095464 0.558 rs73024831 chr5:257192 A/G cg22496380 chr5:211416 CCDC127 -0.91 -10.46 -0.5 2.65e-22 Breast cancer; CRC cis rs1150688 1 rs1150688 chr6:28162780 T/C cg02683197 chr6:28174875 NA 0.48 6.72 0.35 8e-11 Autism spectrum disorder or schizophrenia; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg10173275 chr17:77783551 NA 0.38 6.11 0.32 2.74e-9 Liver disease severity in Alagille syndrome; CRC cis rs7224685 0.501 rs4790559 chr17:4010478 G/T cg11204139 chr17:3907470 NA -0.78 -14.23 -0.62 3.89e-36 Type 2 diabetes; CRC cis rs1223397 0.689 rs2439539 chr6:13308833 G/A cg07912922 chr6:13274314 PHACTR1 0.4 6.12 0.32 2.64e-9 Blood pressure; CRC cis rs9858542 1.000 rs9882740 chr3:49702484 T/C cg00383909 chr3:49044727 WDR6 0.47 5.82 0.31 1.39e-8 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs1046896 0.553 rs56775875 chr17:80831291 G/T cg19046167 chr17:80928561 B3GNTL1 0.52 7.25 0.37 2.97e-12 Glycated hemoglobin levels; CRC trans rs2727020 0.521 rs4980445 chr11:49570183 C/T cg11707556 chr5:10655725 ANKRD33B -0.48 -7.97 -0.4 2.72e-14 Coronary artery disease; CRC trans rs11098499 0.863 rs7664986 chr4:120429952 A/C cg25214090 chr10:38739885 LOC399744 0.63 9.85 0.48 3.24e-20 Corneal astigmatism; CRC cis rs1862618 0.853 rs33326 chr5:56142601 G/A cg12311346 chr5:56204834 C5orf35 -0.79 -10.4 -0.5 4.39e-22 Initial pursuit acceleration; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg11590700 chr3:169381241 MECOM 0.47 7.35 0.38 1.54e-12 Response to antipsychotic treatment; CRC cis rs1552244 1.000 rs7631678 chr3:10078816 T/G cg16606324 chr3:10149918 C3orf24 0.73 9.77 0.47 5.73e-20 Alzheimer's disease; CRC cis rs12410462 0.582 rs2872251 chr1:227647723 G/A cg23173402 chr1:227635558 NA 0.71 8.08 0.41 1.27e-14 Major depressive disorder; CRC cis rs7572644 0.640 rs4632296 chr2:28024984 T/C cg27432699 chr2:27873401 GPN1 0.45 5.68 0.3 2.92e-8 Response to carboplatin and paclitaxel in ovarian cancer (Caspase 3/7 EC50); CRC cis rs1448094 0.511 rs17345975 chr12:86202318 T/A cg19622623 chr12:86230825 RASSF9 -0.37 -5.99 -0.31 5.51e-9 Major depressive disorder; CRC cis rs7660520 0.524 rs6839881 chr4:183729137 A/T cg01126855 chr4:183727586 NA 0.54 5.67 0.3 3.08e-8 Pediatric autoimmune diseases; CRC cis rs7927592 0.763 rs3740628 chr11:68381415 A/G cg01657329 chr11:68192670 LRP5 -0.54 -9.0 -0.44 1.85e-17 Total body bone mineral density; CRC cis rs9858542 0.953 rs7633271 chr3:49555963 T/C cg07274523 chr3:49395745 GPX1 0.48 6.53 0.34 2.43e-10 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs7824557 0.510 rs2736297 chr8:11234885 C/G cg20542592 chr8:11973495 FAM66D 0.32 5.62 0.3 3.98e-8 Retinal vascular caliber; CRC cis rs738322 0.555 rs6001029 chr22:38555193 C/A cg03162506 chr22:38580953 NA 0.28 6.02 0.32 4.63e-9 Cutaneous nevi; CRC cis rs17345786 0.906 rs11708616 chr3:101231731 C/T cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.57 6.78 0.35 5.58e-11 Colonoscopy-negative controls vs population controls; CRC cis rs7607369 0.648 rs17470271 chr2:219651995 A/T cg02176678 chr2:219576539 TTLL4 0.56 9.1 0.45 8.9e-18 Red blood cell count;Amyotrophic lateral sclerosis; CRC cis rs2204008 0.547 rs12318267 chr12:38250905 T/G cg13010199 chr12:38710504 ALG10B -0.39 -5.6 -0.3 4.47e-8 Bladder cancer; CRC cis rs2153535 0.580 rs2184584 chr6:8468407 T/C cg07606381 chr6:8435919 SLC35B3 0.68 10.9 0.51 8.26e-24 Motion sickness; CRC cis rs3008870 1.000 rs3008856 chr1:67387901 T/C cg08660285 chr1:67390436 MIER1;WDR78 1.03 15.78 0.66 3.68e-42 Lymphocyte percentage of white cells; CRC trans rs3942852 0.568 rs10769312 chr11:48094769 C/T cg03929089 chr4:120376271 NA 0.59 8.19 0.41 5.68e-15 Acute lymphoblastic leukemia (childhood); CRC cis rs9649213 0.593 rs34129434 chr7:97926464 C/T cg24562669 chr7:97807699 LMTK2 0.42 7.01 0.36 1.39e-11 Prostate cancer (SNP x SNP interaction); CRC cis rs2949837 0.581 rs2965068 chr7:45974375 T/C cg06713098 chr7:45960367 IGFBP3 0.42 6.79 0.35 5.11e-11 Sitting height ratio; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg26397265 chr12:25348258 LYRM5;CASC1 0.46 7.78 0.39 9.71e-14 Liver disease severity in Alagille syndrome; CRC cis rs11212617 0.967 rs625120 chr11:108095220 A/G cg01991180 chr11:108092276 ATM;NPAT 0.43 6.27 0.33 1.14e-9 Response to metformin in type 2 diabetes (glycemic); CRC cis rs738322 0.967 rs133018 chr22:38572761 G/A cg25457927 chr22:38595422 NA -0.36 -7.57 -0.39 3.83e-13 Cutaneous nevi; CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg00234608 chr9:139702971 C9orf86;LOC100131193 0.37 6.02 0.31 4.63e-9 Obesity-related traits; CRC cis rs9814567 1.000 rs6763093 chr3:134254995 C/G cg06541857 chr3:134203789 ANAPC13;CEP63 0.4 5.82 0.31 1.38e-8 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs9549367 0.601 rs558869 chr13:113849932 G/T cg24300038 chr13:113819356 PROZ 0.51 6.69 0.35 9.53e-11 Platelet distribution width; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg09302848 chr2:48667639 KLRAQ1 0.48 6.87 0.35 3.31e-11 Response to antipsychotic treatment; CRC cis rs11098499 0.863 rs6835635 chr4:120458867 A/G cg09307838 chr4:120376055 NA 0.67 9.92 0.48 1.88e-20 Corneal astigmatism; CRC cis rs4563143 0.663 rs73025068 chr19:29238998 G/A cg12756686 chr19:29218302 NA 0.66 10.26 0.49 1.28e-21 Methadone dose in opioid dependence; CRC cis rs11971779 0.650 rs10085842 chr7:139064582 A/G cg07862535 chr7:139043722 LUC7L2 0.57 7.35 0.38 1.61e-12 Diisocyanate-induced asthma; CRC cis rs34779708 0.966 rs4934734 chr10:35434373 T/C cg03585969 chr10:35415529 CREM 0.66 8.68 0.43 1.88e-16 Inflammatory bowel disease;Crohn's disease; CRC cis rs9858542 1.000 rs9822268 chr3:49719729 G/A cg07274523 chr3:49395745 GPX1 0.46 5.93 0.31 7.68e-9 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs477692 0.569 rs1762418 chr10:131303353 G/A cg05714579 chr10:131428358 MGMT 0.52 7.48 0.38 6.67e-13 Response to temozolomide; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg17492891 chr22:41843204 TOB2 0.47 6.11 0.32 2.8e-9 Thyroid stimulating hormone; CRC cis rs9916302 0.904 rs6503503 chr17:37514373 G/A cg15445000 chr17:37608096 MED1 -0.42 -9.05 -0.45 1.25e-17 Glomerular filtration rate (creatinine); CRC cis rs6912958 0.781 rs6916732 chr6:88259225 C/T cg08069147 chr6:88032118 GJB7;C6orf162 -0.56 -8.43 -0.42 1.12e-15 Monocyte percentage of white cells; CRC cis rs854765 0.964 rs2230316 chr17:17997209 C/T cg16928487 chr17:17741425 SREBF1 0.55 9.05 0.45 1.26e-17 Total body bone mineral density; CRC cis rs7726839 0.540 rs72705097 chr5:655067 G/A cg14541582 chr5:601475 NA -0.33 -6.59 -0.34 1.73e-10 Obesity-related traits; CRC cis rs875971 0.862 rs7786892 chr7:65628876 G/A cg11764359 chr7:65958608 NA -0.61 -9.39 -0.46 1.06e-18 Aortic root size; CRC cis rs35995292 0.500 rs7776996 chr7:38919762 G/C cg19327137 chr7:38886074 VPS41 0.62 10.13 0.49 3.53e-21 Subjective well-being (multi-trait analysis); CRC cis rs7208859 0.623 rs383436 chr17:28959179 A/G cg19761014 chr17:28927070 LRRC37B2 0.57 5.72 0.3 2.41e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs12410462 1.000 rs75360545 chr1:227625419 T/C cg23173402 chr1:227635558 NA 0.71 8.03 0.4 1.71e-14 Major depressive disorder; CRC cis rs514406 0.760 rs1242198 chr1:53352016 G/A cg25767906 chr1:53392781 SCP2 -0.48 -7.75 -0.39 1.19e-13 Monocyte count; CRC cis rs1046896 0.739 rs2379358 chr17:80741612 G/A cg08200770 chr17:80723486 TBCD -0.51 -7.97 -0.4 2.67e-14 Glycated hemoglobin levels; CRC cis rs34172651 0.517 rs1465423 chr16:24772680 C/G cg06505273 chr16:24850292 NA -0.51 -6.68 -0.35 1.03e-10 Intelligence (multi-trait analysis); CRC cis rs7615952 0.576 rs6804482 chr3:125815762 C/T cg15145296 chr3:125709740 NA -0.58 -6.77 -0.35 6.05e-11 Blood pressure (smoking interaction); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg05448504 chr18:72924030 TSHZ1 0.43 6.07 0.32 3.5e-9 Response to antipsychotic treatment; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg03662217 chr21:35747882 FAM165B 0.43 6.03 0.32 4.44e-9 Response to antipsychotic treatment; CRC cis rs6951245 0.935 rs79067319 chr7:1065548 C/T cg18402987 chr7:1209562 NA 0.63 6.72 0.35 7.89e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs2386661 0.547 rs4747358 chr10:5650193 A/G cg17085576 chr10:5658249 NA 0.48 6.83 0.35 4.23e-11 Breast cancer; CRC cis rs10751667 0.666 rs7396473 chr11:966181 T/C cg01483505 chr11:975446 AP2A2 0.46 7.66 0.39 2.11e-13 Alzheimer's disease (late onset); CRC cis rs1707322 0.721 rs10430123 chr1:46221440 T/C cg06784218 chr1:46089804 CCDC17 0.66 12.27 0.56 9.04e-29 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs4974559 0.739 rs28412861 chr4:1320092 A/G cg02980000 chr4:1222292 CTBP1 0.76 8.21 0.41 5.06e-15 Systolic blood pressure; CRC cis rs3796352 1.000 rs35849389 chr3:53005235 A/G cg07884673 chr3:53033167 SFMBT1 0.7 6.19 0.32 1.77e-9 Immune reponse to smallpox (secreted IL-2); CRC cis rs4664293 0.867 rs12692562 chr2:160595710 A/G cg08347373 chr2:160653686 CD302 -0.47 -7.43 -0.38 9.32e-13 Monocyte percentage of white cells; CRC cis rs11690935 0.959 rs6758704 chr2:172655097 T/C cg13550731 chr2:172543902 DYNC1I2 -1.08 -18.27 -0.71 5.57e-52 Schizophrenia; CRC cis rs11098499 0.865 rs9996417 chr4:120295862 T/C cg24375607 chr4:120327624 NA 0.5 7.74 0.39 1.26e-13 Corneal astigmatism; CRC cis rs6066835 0.764 rs3091540 chr20:47391481 A/G cg18078177 chr20:47281410 PREX1 0.69 6.14 0.32 2.39e-9 Multiple myeloma; CRC cis rs4499344 0.633 rs166311 chr19:33161246 A/G cg08127369 chr19:33164662 ANKRD27 0.39 5.93 0.31 7.51e-9 Mean platelet volume; CRC cis rs10743315 0.557 rs1552750 chr12:19356505 A/T cg02471346 chr12:19282374 PLEKHA5 0.77 6.04 0.32 4.2e-9 Gut microbiota (bacterial taxa); CRC cis rs2075371 0.830 rs2077671 chr7:133951204 C/T cg20476274 chr7:133979776 SLC35B4 0.78 14.1 0.61 1.18e-35 Mean platelet volume; CRC cis rs2952156 0.883 rs907089 chr17:37833600 C/T cg00129232 chr17:37814104 STARD3 -0.67 -11.83 -0.55 3.89e-27 Asthma; CRC cis rs7493 0.755 rs17886036 chr7:94987727 C/A cg21856205 chr7:94953877 PON1 -0.45 -5.89 -0.31 9.63e-9 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs2120019 0.935 rs8043181 chr15:75380424 T/C cg09165964 chr15:75287851 SCAMP5 -0.8 -12.56 -0.57 8.3e-30 Blood trace element (Zn levels); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg07772128 chr15:75095447 CSK -0.38 -6.38 -0.33 6.04e-10 Liver disease severity in Alagille syndrome; CRC cis rs2730260 0.537 rs73169233 chr7:158882201 C/T cg02254261 chr7:158964346 NA -0.54 -6.19 -0.32 1.8e-9 Myopia (pathological); CRC cis rs2836950 0.501 rs11702505 chr21:40700614 G/T cg06238570 chr21:40685208 BRWD1 -0.57 -8.2 -0.41 5.57e-15 Menarche (age at onset); CRC cis rs1051424 0.642 rs115869798 chr17:57892829 T/A cg13753209 chr17:57696993 CLTC 0.46 5.85 0.31 1.16e-8 Obesity-related traits; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg16504641 chr6:137143711 PEX7 -0.4 -6.08 -0.32 3.25e-9 Myopia (pathological); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg07881982 chr3:156878112 CCNL1 0.43 5.98 0.31 5.92e-9 Response to antipsychotic treatment; CRC cis rs9322193 0.923 rs1572229 chr6:150064977 T/A cg13206674 chr6:150067644 NUP43 0.67 10.11 0.49 4.23e-21 Lung cancer; CRC cis rs10883723 0.668 rs12414407 chr10:104387019 A/G cg04362960 chr10:104952993 NT5C2 0.41 5.67 0.3 3.17e-8 Allergic disease (asthma, hay fever or eczema); CRC trans rs2797160 0.651 rs1268093 chr6:126029235 C/T cg05039488 chr6:79577232 IRAK1BP1 0.57 8.86 0.44 5.1e-17 Endometrial cancer; CRC cis rs10751667 0.666 rs7936830 chr11:959686 A/G cg23136738 chr11:925521 AP2A2 -0.42 -7.2 -0.37 4.09e-12 Alzheimer's disease (late onset); CRC cis rs826838 1.000 rs851934 chr12:39104453 G/T cg26384229 chr12:38710491 ALG10B -0.62 -9.72 -0.47 8.45e-20 Heart rate; CRC cis rs6456156 0.773 rs6456159 chr6:167529272 T/A cg07513332 chr6:167530253 CCR6 -0.46 -8.45 -0.42 9.59e-16 Primary biliary cholangitis; CRC cis rs7727544 0.507 rs11741341 chr5:131570218 A/G cg01305625 chr5:131593812 PDLIM4 0.32 5.63 0.3 3.85e-8 Blood metabolite levels; CRC cis rs642803 0.591 rs620088 chr11:65508986 G/A cg27068330 chr11:65405492 SIPA1 0.45 5.89 0.31 9.73e-9 Urate levels; CRC trans rs3780486 0.846 rs10813950 chr9:33127640 A/G cg04842962 chr6:43655489 MRPS18A -1.2 -24.25 -0.8 3.14e-75 IgG glycosylation; CRC cis rs6088580 0.634 rs6088508 chr20:33060081 A/G cg24642439 chr20:33292090 TP53INP2 0.38 6.51 0.34 2.76e-10 Glomerular filtration rate (creatinine); CRC cis rs6504622 0.875 rs2316330 chr17:45040032 G/T cg16759221 chr17:45003025 GOSR2 -0.55 -8.68 -0.43 1.85e-16 Orofacial clefts; CRC cis rs10206020 0.885 rs6720923 chr2:1574197 T/C cg12573674 chr2:1569213 NA -0.78 -10.56 -0.5 1.19e-22 IgG glycosylation; CRC cis rs3096299 0.719 rs2353581 chr16:89518908 T/C cg00750074 chr16:89608354 SPG7 -0.53 -8.24 -0.41 4.11e-15 Multiple myeloma (IgH translocation); CRC trans rs79243044 0.786 rs16932549 chr11:5560909 C/T cg23887129 chr19:46234375 FBXO46 -0.43 -6.03 -0.32 4.5e-9 QRS duration in Tripanosoma cruzi seropositivity; CRC cis rs4654899 0.714 rs12133972 chr1:21091338 A/T cg02927042 chr1:21476669 EIF4G3 -0.46 -7.19 -0.37 4.43e-12 Superior frontal gyrus grey matter volume; CRC cis rs8060686 0.641 rs12598274 chr16:68084099 G/A cg26727032 chr16:67993705 SLC12A4 -0.56 -6.47 -0.34 3.57e-10 HDL cholesterol;Metabolic syndrome; CRC cis rs1799949 0.965 rs4793230 chr17:41427403 A/C cg25072359 chr17:41440525 NA 0.55 8.77 0.44 9.71e-17 Menopause (age at onset); CRC cis rs9291683 0.620 rs4444830 chr4:10124819 A/G cg11266682 chr4:10021025 SLC2A9 -0.45 -8.18 -0.41 6.35e-15 Bone mineral density; CRC cis rs6963495 0.556 rs711427 chr7:105161755 T/G cg02135003 chr7:105160482 PUS7 -0.52 -8.08 -0.41 1.22e-14 Bipolar disorder (body mass index interaction); CRC cis rs7932354 0.528 rs10466478 chr11:47162604 A/C cg03339077 chr11:47165057 C11orf49 0.45 6.58 0.34 1.82e-10 Bone mineral density (hip);Bone mineral density; CRC cis rs6540556 0.859 rs1007693 chr1:209931799 C/T cg05527609 chr1:210001259 C1orf107 -0.48 -5.73 -0.3 2.23e-8 Red blood cell count; CRC cis rs7666738 0.822 rs28367231 chr4:98845726 G/T cg17366294 chr4:99064904 C4orf37 0.41 6.58 0.34 1.83e-10 Colonoscopy-negative controls vs population controls; CRC cis rs4919694 1.000 rs4917382 chr10:104838510 G/A cg04362960 chr10:104952993 NT5C2 1.12 10.16 0.49 2.88e-21 Arsenic metabolism; CRC trans rs7618501 1.000 rs4855862 chr3:49748833 C/T cg21582582 chr3:182698605 DCUN1D1 -0.56 -8.25 -0.41 3.82e-15 Intelligence (multi-trait analysis); CRC cis rs4794106 0.792 rs847682 chr17:48208274 C/T cg13893634 chr17:48229117 PPP1R9B -0.42 -6.41 -0.33 5.07e-10 Temporomandibular joint disorder; CRC cis rs2985684 1.000 rs3007030 chr14:50086563 C/T cg23565292 chr14:50234668 KLHDC2 -0.42 -5.87 -0.31 1.05e-8 Carotid intima media thickness; CRC cis rs9467773 0.565 rs6925047 chr6:26521435 C/G cg09904177 chr6:26538194 HMGN4 0.74 11.31 0.53 2.74e-25 Intelligence (multi-trait analysis); CRC cis rs924607 1.000 rs11746907 chr5:598224 G/A cg24163568 chr5:669837 TPPP -0.43 -6.97 -0.36 1.77e-11 Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia; CRC cis rs2637266 0.714 rs11594217 chr10:78385088 G/T cg18941641 chr10:78392320 NA -0.37 -6.49 -0.34 3.11e-10 Pulmonary function; CRC cis rs9326248 0.501 rs4938351 chr11:117022352 A/C cg01368799 chr11:117014884 PAFAH1B2 0.57 9.35 0.46 1.35e-18 Blood protein levels; CRC cis rs1008375 1.000 rs1558378 chr4:17650351 T/C cg16339924 chr4:17578868 LAP3 0.55 7.28 0.37 2.41e-12 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs3785574 0.962 rs2247435 chr17:61892862 G/A cg25654072 chr17:61904446 PSMC5;FTSJ3 0.44 6.01 0.31 4.82e-9 Height; CRC cis rs4731207 0.596 rs6466987 chr7:124677731 C/A cg23710748 chr7:124431027 NA -0.39 -6.11 -0.32 2.83e-9 Cutaneous malignant melanoma; CRC trans rs2303319 0.504 rs56260047 chr2:162497225 G/T cg23247704 chr1:116518985 SLC22A15 -0.7 -6.04 -0.32 4.14e-9 Cognitive function; CRC cis rs311392 1.000 rs2666871 chr8:55089184 C/T cg06042504 chr8:55087323 NA -0.43 -6.75 -0.35 6.71e-11 Pelvic organ prolapse (moderate/severe); CRC cis rs7666738 0.830 rs34070283 chr4:98893027 A/T cg05340658 chr4:99064831 C4orf37 0.56 8.42 0.42 1.16e-15 Colonoscopy-negative controls vs population controls; CRC cis rs78456975 0.657 rs116217838 chr2:1569173 T/C cg26248373 chr2:1572462 NA -0.84 -12.17 -0.56 2.14e-28 Placebo response in major depressive disorder (% change in symptom score); CRC cis rs10751667 0.643 rs7394524 chr11:933865 T/C cg01483505 chr11:975446 AP2A2 0.43 6.82 0.35 4.37e-11 Alzheimer's disease (late onset); CRC cis rs9311474 0.508 rs11720159 chr3:52617802 T/G cg10802521 chr3:52805072 NEK4 -0.57 -9.12 -0.45 7.78e-18 Electroencephalogram traits; CRC cis rs801193 0.569 rs2707824 chr7:66189243 A/G cg00343986 chr7:65444356 GUSB 0.44 6.12 0.32 2.69e-9 Aortic root size; CRC cis rs7769051 0.522 rs60133731 chr6:133095818 T/C cg07930552 chr6:133119739 C6orf192 0.76 7.34 0.37 1.72e-12 Type 2 diabetes nephropathy; CRC cis rs4423214 0.559 rs10898203 chr11:71203436 C/T cg05163923 chr11:71159392 DHCR7 -0.59 -6.01 -0.31 4.98e-9 Vitamin D levels; CRC cis rs8067545 0.641 rs203479 chr17:19829311 T/C cg04132472 chr17:19861366 AKAP10 0.44 6.9 0.36 2.7e-11 Schizophrenia; CRC cis rs4780401 0.678 rs7189287 chr16:11764608 A/G cg01061890 chr16:11836724 TXNDC11 -0.41 -5.61 -0.3 4.35e-8 Rheumatoid arthritis; CRC cis rs853679 0.517 rs12174753 chr6:28042465 C/G cg02631126 chr6:28058918 ZSCAN12L1 0.29 6.03 0.32 4.35e-9 Depression; CRC cis rs6662572 0.737 rs6659064 chr1:46346724 G/C cg08644498 chr1:46502608 NA -0.45 -7.07 -0.36 9.42e-12 Blood protein levels; CRC cis rs2882667 0.858 rs11242448 chr5:138443154 C/A cg09476006 chr5:138032270 NA 0.45 6.9 0.36 2.69e-11 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs67311347 0.544 rs1902073 chr3:40333497 C/T cg09455208 chr3:40491958 NA 0.32 6.41 0.33 5.19e-10 Renal cell carcinoma; CRC cis rs995000 0.931 rs1168009 chr1:62943954 G/A cg19896129 chr1:63156450 NA -0.39 -6.02 -0.31 4.78e-9 Triglyceride levels; CRC cis rs2235642 0.653 rs7197288 chr16:1654753 C/A cg26528668 chr16:1614120 IFT140 0.38 5.86 0.31 1.11e-8 Coronary artery disease; CRC cis rs1568889 1.000 rs78140392 chr11:28203231 C/G cg06544937 chr11:28130018 METT5D1;KIF18A 0.78 10.98 0.52 4.29e-24 Bipolar disorder; CRC cis rs728616 0.867 rs4520539 chr10:81740529 C/G cg05935833 chr10:81318306 SFTPA2 -0.76 -8.28 -0.42 3.12e-15 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs9611565 0.765 rs132914 chr22:41805749 T/C cg06634786 chr22:41940651 POLR3H 0.62 7.19 0.37 4.42e-12 Vitiligo; CRC cis rs4566357 0.576 rs10187255 chr2:227913442 T/A cg11843606 chr2:227700838 RHBDD1 -0.44 -6.79 -0.35 5.1e-11 Coronary artery disease; CRC cis rs1552244 1.000 rs7631678 chr3:10078816 T/G cg08888203 chr3:10149979 C3orf24 0.73 10.08 0.49 5.45e-21 Alzheimer's disease; CRC cis rs17270561 0.583 rs9393661 chr6:25739080 C/T cg16482183 chr6:26056742 HIST1H1C 0.83 10.58 0.5 1.07e-22 Iron status biomarkers; CRC cis rs2836974 0.583 rs9636957 chr21:40705847 G/A cg11890956 chr21:40555474 PSMG1 -0.83 -13.34 -0.59 9.52e-33 Cognitive function; CRC cis rs2239547 0.522 rs2336669 chr3:52994138 C/T cg11645453 chr3:52864694 ITIH4 -0.53 -9.35 -0.46 1.37e-18 Schizophrenia; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg24515799 chr6:149867235 PPIL4 0.44 6.18 0.32 1.95e-9 Anxiety disorder; CRC cis rs2806561 0.765 rs2806565 chr1:23507068 A/G cg12483005 chr1:23474871 LUZP1 0.51 7.52 0.38 5.21e-13 Height; CRC cis rs12908161 0.960 rs17599989 chr15:85285536 A/G cg11189052 chr15:85197271 WDR73 0.58 8.57 0.43 4.05e-16 Schizophrenia; CRC trans rs2303319 0.504 rs57464189 chr2:162419312 G/A cg18122310 chr12:50236657 BCDIN3D -0.72 -6.04 -0.32 4.15e-9 Cognitive function; CRC cis rs694739 0.654 rs10897488 chr11:64140806 T/C cg02228329 chr11:64053129 BAD;GPR137 0.49 6.7 0.35 8.88e-11 Alopecia areata;Crohn's disease;Psoriasis vulgaris; CRC cis rs826838 0.709 rs4882355 chr12:38721462 A/T cg13010199 chr12:38710504 ALG10B 0.43 6.26 0.33 1.19e-9 Heart rate; CRC cis rs769267 0.965 rs2315025 chr19:19426609 C/T cg17414380 chr19:19431394 KIAA0892;SF4 0.41 5.66 0.3 3.28e-8 Tonsillectomy; CRC cis rs12586317 0.547 rs77262907 chr14:35495734 C/G cg16230307 chr14:35515116 FAM177A1 0.9 10.55 0.5 1.36e-22 Psoriasis; CRC cis rs6748734 1.000 rs6751693 chr2:241837332 T/C cg16358738 chr2:241808595 AGXT -0.39 -5.79 -0.3 1.68e-8 Urinary metabolites; CRC cis rs1552244 1.000 rs17032414 chr3:10158302 C/G cg10729496 chr3:10149963 C3orf24 0.46 6.18 0.32 1.87e-9 Alzheimer's disease; CRC cis rs9911578 1.000 rs9898626 chr17:56698219 C/G cg12560992 chr17:57184187 TRIM37 0.91 16.61 0.68 1.98e-45 Intelligence (multi-trait analysis); CRC cis rs1401999 1.000 rs939336 chr3:183685534 A/G cg20387954 chr3:183756860 HTR3D 0.44 7.55 0.38 4.43e-13 Anterior chamber depth; CRC cis rs4332037 0.624 rs56256289 chr7:1892529 C/T cg21155852 chr7:2048760 MAD1L1 -0.41 -6.01 -0.31 4.98e-9 Bipolar disorder; CRC cis rs1949733 1.000 rs6837429 chr4:8502374 A/G cg11789530 chr4:8429930 ACOX3 0.85 12.55 0.57 8.88e-30 Response to antineoplastic agents; CRC cis rs11997175 1.000 rs11997175 chr8:33770070 A/G ch.8.33884649F chr8:33765107 NA -0.45 -6.73 -0.35 7.67e-11 Body mass index; CRC cis rs17270561 0.525 rs10484432 chr6:26008876 G/A cg16482183 chr6:26056742 HIST1H1C 1.06 12.96 0.58 2.67e-31 Iron status biomarkers; CRC cis rs7113874 0.569 rs2871753 chr11:8486650 A/T cg02811074 chr11:8615871 STK33 0.36 6.15 0.32 2.24e-9 Body mass index in physically active individuals;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs9443645 0.901 rs9361466 chr6:79618352 T/C cg09184832 chr6:79620586 NA -0.51 -9.54 -0.47 3.3e-19 Intelligence (multi-trait analysis); CRC cis rs8060686 0.641 rs75796305 chr16:68208791 A/G cg26727032 chr16:67993705 SLC12A4 -0.53 -6.17 -0.32 1.99e-9 HDL cholesterol;Metabolic syndrome; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg05142140 chr3:49055321 DALRD3 0.44 6.26 0.33 1.21e-9 Response to antipsychotic treatment; CRC cis rs9858542 0.953 rs1873625 chr3:49666964 C/A cg03060546 chr3:49711283 APEH -0.52 -7.01 -0.36 1.32e-11 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs11948739 0.501 rs971699 chr5:130361558 A/G cg08523029 chr5:130500466 HINT1 -0.45 -5.91 -0.31 8.77e-9 Pediatric bone mineral content (hip); CRC cis rs4563143 0.675 rs73025085 chr19:29247018 C/A cg14983838 chr19:29218262 NA 0.46 6.76 0.35 6.47e-11 Methadone dose in opioid dependence; CRC cis rs7659604 0.643 rs6839054 chr4:122663628 C/T cg06713675 chr4:122721982 EXOSC9 -0.38 -5.88 -0.31 1.01e-8 Type 2 diabetes; CRC cis rs6502050 0.814 rs9894554 chr17:80073423 C/G cg19223190 chr17:80058835 NA -0.42 -6.68 -0.35 1.04e-10 Life satisfaction; CRC cis rs644799 0.601 rs662168 chr11:95586982 C/T cg25622487 chr11:95524042 FAM76B;CEP57 0.69 10.89 0.51 8.58e-24 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs911555 0.755 rs7148567 chr14:103882234 C/T cg24130564 chr14:104152367 KLC1 -0.43 -5.8 -0.3 1.53e-8 Intelligence (multi-trait analysis); CRC cis rs7089973 0.604 rs7914792 chr10:116591391 T/C cg23260525 chr10:116636907 FAM160B1 0.35 8.07 0.41 1.34e-14 Bipolar disorder or attention deficit hyperactivity disorder; CRC cis rs3820068 0.705 rs57971278 chr1:15838604 G/A cg27534772 chr1:16042836 PLEKHM2 0.42 7.07 0.36 9.23e-12 Systolic blood pressure; CRC cis rs4713118 0.666 rs4140646 chr6:27738801 G/A cg15845792 chr6:28175446 NA 0.7 7.65 0.39 2.28e-13 Parkinson's disease; CRC cis rs7617773 0.747 rs34076262 chr3:48370416 C/T cg11946769 chr3:48343235 NME6 0.72 9.58 0.47 2.48e-19 Coronary artery disease; CRC cis rs2032447 0.798 rs807212 chr6:26065621 A/G cg03517284 chr6:25882590 NA -0.5 -6.8 -0.35 4.81e-11 Intelligence (multi-trait analysis); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg27366207 chr19:28287704 NA 0.43 6.57 0.34 1.95e-10 Liver disease severity in Alagille syndrome; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg17783671 chr19:59070436 UBE2M;LOC100131691 0.43 6.91 0.36 2.54e-11 Liver disease severity in Alagille syndrome; CRC cis rs6951245 0.832 rs79808627 chr7:1092519 C/G cg27454412 chr7:1067447 C7orf50 0.5 5.65 0.3 3.55e-8 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs561341 0.882 rs504887 chr17:30322881 T/A cg23018236 chr17:30244563 NA -0.61 -7.89 -0.4 4.49e-14 Hip circumference adjusted for BMI; CRC cis rs6831352 0.734 rs1453872 chr4:100022482 G/A cg12011299 chr4:100065546 ADH4 0.44 8.72 0.43 1.37e-16 Alcohol dependence; CRC cis rs2455799 0.573 rs2470539 chr3:15717844 C/T cg16303742 chr3:15540471 COLQ -0.38 -5.77 -0.3 1.8e-8 Mean platelet volume; CRC cis rs6502050 0.835 rs8080625 chr17:80115447 G/A cg11859384 chr17:80120422 CCDC57 -0.37 -5.98 -0.31 5.86e-9 Life satisfaction; CRC cis rs7772486 0.654 rs4896829 chr6:145953675 T/A cg23711669 chr6:146136114 FBXO30 0.71 11.77 0.54 6.27e-27 Lobe attachment (rater-scored or self-reported); CRC cis rs9323205 0.634 rs56043194 chr14:51726066 A/C cg23942311 chr14:51606299 NA -0.52 -6.18 -0.32 1.9e-9 Cancer; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg17907730 chr7:35077704 DPY19L1 0.46 6.48 0.34 3.31e-10 Anxiety disorder; CRC cis rs9322193 0.926 rs3805751 chr6:150112329 G/A cg05861140 chr6:150128134 PCMT1 -0.42 -6.76 -0.35 6.48e-11 Lung cancer; CRC trans rs3774749 0.565 rs2188151 chr3:50201924 A/C cg21659725 chr3:3221576 CRBN -0.44 -6.49 -0.34 3.24e-10 Intelligence (multi-trait analysis); CRC cis rs9311474 0.508 rs6788887 chr3:52605005 T/C cg18099408 chr3:52552593 STAB1 -0.48 -8.3 -0.42 2.81e-15 Electroencephalogram traits; CRC cis rs28830936 1.000 rs11637341 chr15:41955825 G/T cg17847044 chr15:42102381 MAPKBP1 -0.3 -6.35 -0.33 7.13e-10 Diastolic blood pressure; CRC cis rs7586879 0.964 rs11688665 chr2:25121168 G/T cg04586622 chr2:25135609 ADCY3 -0.43 -7.29 -0.37 2.34e-12 Body mass index; CRC cis rs10751667 0.600 rs7394783 chr11:1005108 C/T ch.11.42038R chr11:967971 AP2A2 -0.56 -8.77 -0.44 9.77e-17 Alzheimer's disease (late onset); CRC trans rs11098499 0.955 rs13113112 chr4:120156040 C/T cg25214090 chr10:38739885 LOC399744 0.51 7.71 0.39 1.47e-13 Corneal astigmatism; CRC cis rs6502050 0.805 rs9898507 chr17:80119628 C/T cg09264619 chr17:80180166 NA -0.35 -5.93 -0.31 7.47e-9 Life satisfaction; CRC trans rs9858542 0.953 rs12330269 chr3:49513910 G/A cg21659725 chr3:3221576 CRBN -0.66 -8.98 -0.44 2.18e-17 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs11077998 1.000 rs11077998 chr17:80483946 C/G cg10255544 chr17:80519551 FOXK2 -0.39 -6.07 -0.32 3.52e-9 Reticulocyte fraction of red cells; CRC cis rs2836974 0.932 rs2150415 chr21:40615367 A/G cg11890956 chr21:40555474 PSMG1 1.09 18.69 0.72 1.25e-53 Cognitive function; CRC cis rs3617 0.625 rs11715347 chr3:52883070 C/T cg15147215 chr3:52552868 STAB1 0.51 8.9 0.44 3.79e-17 Red blood cell count;Autism spectrum disorder or schizophrenia; CRC cis rs362272 0.545 rs3129308 chr4:3309272 C/T cg01612440 chr4:3296283 NA 0.39 5.67 0.3 3.19e-8 Serum sulfate level; CRC cis rs2932538 0.922 rs6698030 chr1:113138318 G/A cg22162597 chr1:113214053 CAPZA1 0.71 10.05 0.48 6.62e-21 Systolic blood pressure;Diastolic blood pressure;Hypertension;Blood pressure; CRC cis rs9322193 0.923 rs2880436 chr6:150180259 T/C cg07701084 chr6:150067640 NUP43 0.53 7.23 0.37 3.31e-12 Lung cancer; CRC cis rs9733 0.596 rs2867300 chr1:150666990 C/G cg17724175 chr1:150552817 MCL1 0.6 9.59 0.47 2.37e-19 Tonsillectomy; CRC cis rs713587 0.563 rs7591460 chr2:25103967 A/C cg04586622 chr2:25135609 ADCY3 -0.55 -10.05 -0.48 6.56e-21 Body mass index in non-asthmatics; CRC cis rs10464366 0.571 rs13233049 chr7:39187536 C/T cg15212455 chr7:39170539 POU6F2 0.5 6.56 0.34 2.03e-10 IgG glycosylation; CRC cis rs9549328 0.837 rs9549618 chr13:113628648 G/A cg08614441 chr13:113633676 MCF2L -0.53 -9.34 -0.46 1.48e-18 Systolic blood pressure; CRC cis rs826838 1.000 rs10506122 chr12:38699232 A/G cg26384229 chr12:38710491 ALG10B 0.78 11.19 0.52 7.73e-25 Heart rate; CRC cis rs7512552 0.803 rs7513205 chr1:150472781 A/G cg15654264 chr1:150340011 RPRD2 0.6 8.4 0.42 1.35e-15 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); CRC cis rs3806843 1.000 rs6898906 chr5:140169299 C/G cg19875535 chr5:140030758 IK 0.6 9.78 0.47 5.3e-20 Depressive symptoms (multi-trait analysis); CRC cis rs6684514 1.000 rs12040868 chr1:156284803 G/T cg16558208 chr1:156270281 VHLL 0.58 9.0 0.44 1.9e-17 Mean corpuscular hemoglobin concentration;Glycated hemoglobin levels; CRC cis rs6662572 0.737 rs11211247 chr1:46476587 G/T cg03123370 chr1:45965343 CCDC163P;MMACHC 0.47 6.18 0.32 1.94e-9 Blood protein levels; CRC cis rs780096 0.546 rs2911712 chr2:27626945 A/T cg12000995 chr2:27665139 KRTCAP3 -0.31 -6.43 -0.33 4.54e-10 Total body bone mineral density; CRC cis rs883565 0.655 rs4676670 chr3:39049594 A/C cg01426195 chr3:39028469 NA -0.53 -8.56 -0.43 4.52e-16 Handedness; CRC cis rs13090388 1 rs13090388 chr3:49391082 C/T cg00383909 chr3:49044727 WDR6 0.44 5.67 0.3 3.07e-8 Intelligence (multi-trait analysis);Educational attainment (years of education); CRC trans rs3960554 0.808 rs112372188 chr7:75723376 G/A cg19862616 chr7:65841803 NCRNA00174 0.77 8.54 0.43 4.88e-16 Eotaxin levels; CRC cis rs10242455 1.000 rs28468623 chr7:98922812 C/G cg18809830 chr7:99032528 PTCD1 -0.74 -6.39 -0.33 5.68e-10 Blood metabolite levels; CRC cis rs3740540 0.530 rs4297414 chr10:126292116 T/G cg04949429 chr10:126290192 LHPP 0.43 6.44 0.33 4.28e-10 Obesity-related traits;Acute lymphoblastic leukemia (childhood); CRC cis rs9291683 1.000 rs9291683 chr4:10324160 C/T cg11266682 chr4:10021025 SLC2A9 0.43 8.8 0.44 7.81e-17 Bone mineral density; CRC cis rs908922 0.676 rs2282296 chr1:152487979 C/T cg09873164 chr1:152488093 CRCT1 0.38 6.34 0.33 7.57e-10 Hair morphology; CRC cis rs7662987 0.517 rs2851263 chr4:100030354 A/G cg13256891 chr4:100009986 ADH5 0.63 8.56 0.43 4.54e-16 Smoking initiation; CRC cis rs172166 0.515 rs2622320 chr6:28115336 T/A cg15786705 chr6:28176104 NA 0.48 7.21 0.37 3.76e-12 Cardiac Troponin-T levels; CRC cis rs4665809 0.680 rs3955310 chr2:26290828 T/G cg27170947 chr2:26402098 FAM59B -0.44 -5.85 -0.31 1.16e-8 Gut microbiome composition (summer); CRC cis rs735539 1.000 rs9579929 chr13:21282724 C/T cg27499820 chr13:21296301 IL17D -0.36 -5.94 -0.31 7.21e-9 Dental caries; CRC cis rs11249608 0.636 rs6888539 chr5:178449010 T/A cg01312482 chr5:178451176 ZNF879 -0.36 -6.03 -0.32 4.3e-9 Pubertal anthropometrics; CRC cis rs250677 0.687 rs36043 chr5:148440983 G/A cg18129178 chr5:148520854 ABLIM3 -0.37 -5.88 -0.31 1.02e-8 Breast cancer; CRC cis rs709400 0.663 rs62007683 chr14:103894071 G/T cg12935359 chr14:103987150 CKB -0.52 -8.06 -0.41 1.43e-14 Body mass index; CRC cis rs9359856 0.518 rs10944451 chr6:90262341 A/G cg13799429 chr6:90582589 CASP8AP2 -0.59 -6.83 -0.35 4.2e-11 Bipolar disorder; CRC cis rs875971 0.800 rs427557 chr7:65519250 A/G cg00343986 chr7:65444356 GUSB 0.47 6.95 0.36 1.99e-11 Aortic root size; CRC cis rs780096 0.546 rs12473776 chr2:27636474 A/G cg24768116 chr2:27665128 KRTCAP3 -0.35 -7.99 -0.4 2.25e-14 Total body bone mineral density; CRC cis rs10504229 0.683 rs6982990 chr8:58115275 C/T cg04204079 chr8:58130323 NA 0.42 5.62 0.3 4.18e-8 Developmental language disorder (linguistic errors); CRC cis rs6685188 0.920 rs6676110 chr1:205662977 G/A cg14893161 chr1:205819251 PM20D1 -0.45 -6.37 -0.33 6.21e-10 White blood cell count (basophil);Basophil percentage of white cells; CRC cis rs1448094 0.817 rs10863108 chr12:86328249 C/T cg18827107 chr12:86230957 RASSF9 -0.42 -6.62 -0.34 1.48e-10 Major depressive disorder; CRC cis rs4820539 0.966 rs2301554 chr22:23484254 A/C cg14186256 chr22:23484241 RTDR1 0.93 18.62 0.72 2.45e-53 Bone mineral density; CRC cis rs61996546 0.622 rs17560717 chr15:26834211 G/C cg15066197 chr15:26874202 GABRB3 -0.4 -5.99 -0.31 5.41e-9 Response to methotrexate in juvenile idiopathic arthritis; CRC trans rs877282 0.853 rs7083589 chr10:754494 G/A cg22713356 chr15:30763199 NA 1.19 13.88 0.61 8.17e-35 Uric acid levels; CRC cis rs6762477 0.505 rs17304079 chr3:50085153 A/G cg24110177 chr3:50126178 RBM5 -0.49 -5.7 -0.3 2.68e-8 Menarche (age at onset); CRC cis rs7927592 0.956 rs2155730 chr11:68329474 T/C cg01657329 chr11:68192670 LRP5 -0.5 -7.47 -0.38 7.31e-13 Total body bone mineral density; CRC cis rs950169 1.000 rs1911155 chr15:84787635 A/G cg11189052 chr15:85197271 WDR73 0.61 8.95 0.44 2.73e-17 Schizophrenia; CRC trans rs61931739 0.517 rs1843738 chr12:34056935 C/T cg26384229 chr12:38710491 ALG10B 0.53 6.77 0.35 5.85e-11 Morning vs. evening chronotype; CRC cis rs8028182 0.636 rs4545784 chr15:75755651 A/G cg20655648 chr15:75932815 IMP3 0.42 6.39 0.33 5.72e-10 Sudden cardiac arrest; CRC cis rs1552244 1.000 rs3846177 chr3:10068572 G/T cg18598329 chr3:10140678 FANCD2;C3orf24 -0.88 -12.22 -0.56 1.48e-28 Alzheimer's disease; CRC cis rs12477438 0.520 rs13030961 chr2:99799520 C/G cg14399236 chr2:99771627 LIPT1;TSGA10 0.81 14.26 0.62 2.87e-36 Chronic sinus infection; CRC cis rs6540559 0.611 rs76766079 chr1:209997731 C/T cg22029157 chr1:209979665 IRF6 0.68 7.81 0.4 7.71e-14 Cleft lip with or without cleft palate; CRC cis rs6570726 0.846 rs6919684 chr6:145883801 A/G cg05347473 chr6:146136440 FBXO30 0.38 5.8 0.3 1.53e-8 Lobe attachment (rater-scored or self-reported); CRC cis rs853679 0.517 rs9368557 chr6:28131537 T/C cg12963246 chr6:28129442 ZNF389 0.49 5.7 0.3 2.71e-8 Depression; CRC cis rs6089584 0.566 rs6061972 chr20:60610245 C/T cg13770153 chr20:60521292 NA -0.48 -7.17 -0.37 4.87e-12 Body mass index; CRC cis rs798554 0.836 rs798490 chr7:2801542 C/T cg04166393 chr7:2884313 GNA12 0.52 6.89 0.36 2.84e-11 Height; CRC cis rs354225 0.554 rs10166844 chr2:54798272 T/C cg26097391 chr2:54893211 SPTBN1 0.38 5.7 0.3 2.73e-8 Schizophrenia; CRC cis rs1865760 0.566 rs9379821 chr6:26054268 A/C cg18357526 chr6:26021779 HIST1H4A 0.41 5.77 0.3 1.8e-8 Height; CRC cis rs561341 0.941 rs8081016 chr17:30331751 A/G cg19193384 chr17:30244184 NA -0.65 -7.58 -0.39 3.51e-13 Hip circumference adjusted for BMI; CRC cis rs9549328 0.700 rs34890317 chr13:113617245 G/C cg24588162 chr13:113633484 MCF2L 0.36 6.49 0.34 3.22e-10 Systolic blood pressure; CRC cis rs7666738 0.830 rs28852677 chr4:99039509 T/G cg05340658 chr4:99064831 C4orf37 0.6 9.45 0.46 6.36e-19 Colonoscopy-negative controls vs population controls; CRC cis rs6456156 0.875 rs55802221 chr6:167517320 G/A cg07741184 chr6:167504864 NA -0.4 -6.95 -0.36 2e-11 Primary biliary cholangitis; CRC cis rs9309473 0.898 rs10185080 chr2:73797507 C/A cg20560298 chr2:73613845 ALMS1 -0.47 -5.81 -0.31 1.47e-8 Metabolite levels; CRC cis rs6582630 0.638 rs12425379 chr12:38523705 G/A cg13010199 chr12:38710504 ALG10B -0.42 -6.04 -0.32 4.07e-9 Drug-induced liver injury (flucloxacillin); CRC cis rs7605827 0.897 rs1919292 chr2:15567236 A/G cg19274914 chr2:15703543 NA 0.37 5.74 0.3 2.14e-8 Educational attainment (years of education); CRC cis rs372883 0.648 rs1003772 chr21:30736145 A/T cg08807101 chr21:30365312 RNF160 0.58 8.11 0.41 1.02e-14 Pancreatic cancer; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg09015484 chr9:96929106 NA 0.45 6.37 0.33 6.46e-10 Response to antipsychotic treatment; CRC cis rs4722166 0.695 rs56061963 chr7:22800397 T/C cg26061582 chr7:22766209 IL6 0.49 7.62 0.39 2.76e-13 Lung cancer; CRC cis rs72781680 1.000 rs55982282 chr2:24188128 G/A cg08917208 chr2:24149416 ATAD2B 1.04 10.29 0.49 9.91e-22 Lymphocyte counts; CRC cis rs28655083 1.000 rs1875582 chr16:77063147 A/G cg01753188 chr16:77233325 SYCE1L;MON1B 0.59 8.34 0.42 2.11e-15 Lobe attachment (rater-scored or self-reported); CRC cis rs7202877 0.706 rs8046184 chr16:75411725 T/C cg03315344 chr16:75512273 CHST6 0.49 5.65 0.3 3.51e-8 Type 2 diabetes;Type 1 diabetes; CRC trans rs10504229 1.000 rs34616626 chr8:58184650 C/T cg04077850 chr5:125800366 GRAMD3 0.37 6.27 0.33 1.15e-9 Developmental language disorder (linguistic errors); CRC cis rs12130219 0.500 rs4845743 chr1:152184149 A/G cg23107878 chr1:152161397 NA 0.4 5.84 0.31 1.22e-8 Inflammatory skin disease; CRC cis rs10464366 0.544 rs4355688 chr7:39158402 C/T cg15212455 chr7:39170539 POU6F2 0.5 6.65 0.34 1.21e-10 IgG glycosylation; CRC cis rs7811142 0.775 rs1636980 chr7:99938864 A/G cg01860168 chr7:100026446 MEPCE;ZCWPW1 -0.61 -7.97 -0.4 2.66e-14 Platelet count; CRC cis rs780096 0.526 rs1647267 chr2:27651054 A/T cg12000995 chr2:27665139 KRTCAP3 -0.31 -6.48 -0.34 3.29e-10 Total body bone mineral density; CRC cis rs668210 0.947 rs610497 chr11:65765551 C/T cg02202077 chr11:65769826 EIF1AD;BANF1 0.44 6.17 0.32 2.01e-9 Cerebrospinal fluid biomarker levels; CRC cis rs1129187 0.755 rs9462856 chr6:42926024 T/C cg21280719 chr6:42927975 GNMT -0.48 -10.51 -0.5 1.82e-22 Alzheimer's disease in APOE e4+ carriers; CRC cis rs8180040 0.845 rs295441 chr3:47333295 T/A cg10298567 chr3:47292165 KIF9 -0.4 -6.72 -0.35 7.9e-11 Colorectal cancer; CRC cis rs801193 0.569 rs11761542 chr7:66218196 G/A cg11764359 chr7:65958608 NA 0.58 8.71 0.43 1.55e-16 Aortic root size; CRC cis rs6502050 0.871 rs11870632 chr17:80075406 T/C cg22110888 chr17:80059540 CCDC57 -0.42 -6.62 -0.34 1.48e-10 Life satisfaction; CRC cis rs116095464 0.558 rs10075018 chr5:239175 G/A cg22496380 chr5:211416 CCDC127 -0.91 -10.38 -0.5 5.2e-22 Breast cancer; CRC cis rs9322193 0.923 rs9767652 chr6:150055638 A/T cg13206674 chr6:150067644 NUP43 0.66 9.52 0.46 3.79e-19 Lung cancer; CRC cis rs72772090 0.539 rs56395748 chr5:96176893 G/T cg17330273 chr5:96107758 CAST;ERAP1 -0.59 -5.77 -0.3 1.82e-8 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg00399650 chr7:141402322 KIAA1147 0.45 6.32 0.33 8.27e-10 Response to antipsychotic treatment; CRC cis rs9292777 0.966 rs6861824 chr5:40432412 A/G cg09067459 chr5:40385259 NA 0.51 8.91 0.44 3.5e-17 Crohn's disease;Multiple sclerosis; CRC trans rs12599106 0.709 rs1501462 chr16:34964515 A/T cg01171360 chr6:293285 DUSP22 -0.56 -8.06 -0.41 1.45e-14 Menopause (age at onset); CRC cis rs798554 0.757 rs1182187 chr7:2870454 T/G cg19346786 chr7:2764209 NA -0.38 -6.55 -0.34 2.24e-10 Height; CRC cis rs9326248 0.559 rs476399 chr11:116733728 T/C cg11861562 chr11:117069780 TAGLN 0.26 5.89 0.31 9.34e-9 Blood protein levels; CRC cis rs2742417 0.603 rs2253979 chr3:45773320 A/G cg04837898 chr3:45731254 SACM1L -0.47 -7.55 -0.38 4.42e-13 Response to anti-depressant treatment in major depressive disorder; CRC cis rs17443541 0.516 rs1450569 chr2:200443111 A/T cg03741458 chr2:200468445 NA -0.38 -5.95 -0.31 6.77e-9 Intelligence (multi-trait analysis); CRC cis rs1865760 1.000 rs3752421 chr6:25918688 G/A cg16482183 chr6:26056742 HIST1H1C 0.54 7.79 0.39 8.74e-14 Height; CRC cis rs40363 0.723 rs8060367 chr16:3537919 C/A cg00484396 chr16:3507460 NAT15 -0.6 -6.09 -0.32 3.2e-9 Tuberculosis; CRC cis rs7769051 1.000 rs6934161 chr6:133124077 C/T cg07930552 chr6:133119739 C6orf192 -0.61 -7.16 -0.37 5.28e-12 Type 2 diabetes nephropathy; CRC cis rs6867032 0.527 rs13162781 chr5:2012235 C/T cg26168224 chr5:2018326 NA 0.71 11.65 0.54 1.7e-26 Gut microbiome composition (winter); CRC cis rs1559088 1.000 rs2161225 chr19:33551899 C/T cg27124370 chr19:33622961 WDR88 0.41 5.77 0.3 1.83e-8 Bone ultrasound measurement (broadband ultrasound attenuation); CRC cis rs314370 0.951 rs17881696 chr7:100493359 G/A cg10426581 chr7:100472382 SRRT 0.62 7.11 0.36 7.24e-12 Resting heart rate; CRC cis rs4926298 1.000 rs11085829 chr19:13174312 G/A cg11738485 chr19:12877000 HOOK2 -0.43 -5.93 -0.31 7.58e-9 Bipolar disorder; CRC cis rs9486715 0.867 rs2223238 chr6:96871855 G/A cg18709589 chr6:96969512 KIAA0776 0.47 7.01 0.36 1.34e-11 Headache; CRC cis rs344364 0.511 rs2906912 chr16:1953151 G/A cg09830162 chr16:1889614 FAHD1;C16orf73 -0.74 -9.17 -0.45 5.38e-18 Glomerular filtration rate in chronic kidney disease; CRC trans rs7937682 0.889 rs484013 chr11:111495779 G/A cg18187862 chr3:45730750 SACM1L 0.46 6.63 0.34 1.35e-10 Primary sclerosing cholangitis; CRC cis rs9807989 0.507 rs4851004 chr2:103009537 A/G cg03938978 chr2:103052716 IL18RAP -0.59 -10.45 -0.5 2.99e-22 Asthma; CRC cis rs6502050 0.604 rs9897355 chr17:80078095 G/A cg25804541 chr17:80189381 SLC16A3 0.32 6.12 0.32 2.72e-9 Life satisfaction; CRC cis rs10504229 0.679 rs17801003 chr8:58050930 A/G cg02725872 chr8:58115012 NA -0.51 -7.09 -0.36 8.18e-12 Developmental language disorder (linguistic errors); CRC cis rs2845885 1.000 rs2845885 chr11:63869062 A/G cg24431193 chr11:63883947 FLRT1;MACROD1 0.63 5.85 0.31 1.2e-8 Body mass index; CRC cis rs1757171 0.504 rs11969056 chr6:37484285 C/T cg01843034 chr6:37503916 NA -0.41 -7.59 -0.39 3.3e-13 Cognitive performance; CRC cis rs1552244 0.751 rs12715665 chr3:10021601 C/T cg18598329 chr3:10140678 FANCD2;C3orf24 -0.83 -11.7 -0.54 1.11e-26 Alzheimer's disease; CRC trans rs459571 0.839 rs2519831 chr9:136886257 T/A cg09836344 chr4:1243392 C4orf42;CTBP1 -0.84 -12.01 -0.55 8.64e-28 Platelet distribution width; CRC cis rs3733585 0.699 rs7686538 chr4:9948077 C/T cg00071950 chr4:10020882 SLC2A9 -0.55 -9.63 -0.47 1.62e-19 Cleft plate (environmental tobacco smoke interaction); CRC cis rs9308731 0.644 rs4849403 chr2:111874037 T/C cg04202892 chr2:111875749 ACOXL 0.43 6.97 0.36 1.74e-11 Chronic lymphocytic leukemia; CRC cis rs3806843 0.771 rs2563334 chr5:140107065 C/G cg19875535 chr5:140030758 IK -0.63 -10.27 -0.49 1.2e-21 Depressive symptoms (multi-trait analysis); CRC cis rs3796619 0.961 rs11732520 chr4:1074009 C/T cg27284194 chr4:1044797 NA 0.39 6.13 0.32 2.57e-9 Recombination rate (males); CRC cis rs1448094 0.737 rs10863135 chr12:86382657 C/T cg18827107 chr12:86230957 RASSF9 -0.37 -5.93 -0.31 7.87e-9 Major depressive disorder; CRC cis rs6499255 0.951 rs12595878 chr16:69628217 C/T cg15192750 chr16:69999425 NA 0.56 7.44 0.38 9.02e-13 IgE levels; CRC cis rs2760061 0.819 rs1745417 chr1:228204279 C/T cg02753203 chr1:228287806 NA 0.68 10.55 0.5 1.34e-22 Diastolic blood pressure; CRC cis rs6121246 0.528 rs6060252 chr20:30191084 A/G cg18721089 chr20:30220636 NA -0.52 -7.93 -0.4 3.54e-14 Mean corpuscular hemoglobin; CRC trans rs8002861 0.781 rs9525857 chr13:44437072 T/C cg17145862 chr1:211918768 LPGAT1 0.72 14.34 0.62 1.46e-36 Leprosy; CRC cis rs9916302 0.904 rs10491128 chr17:37551988 G/A cg07936489 chr17:37558343 FBXL20 0.83 12.53 0.57 1.06e-29 Glomerular filtration rate (creatinine); CRC cis rs1862618 0.802 rs986049 chr5:56110233 G/A cg24531977 chr5:56204891 C5orf35 -0.83 -11.28 -0.53 3.7e-25 Initial pursuit acceleration; CRC cis rs6504340 0.793 rs12946855 chr17:46608030 G/A cg04904318 chr17:46607828 HOXB1 -0.54 -6.63 -0.34 1.37e-10 Primary tooth development (number of teeth); CRC trans rs7937682 1.000 rs11213980 chr11:111562692 A/T cg18187862 chr3:45730750 SACM1L -0.49 -6.74 -0.35 7.05e-11 Primary sclerosing cholangitis; CRC cis rs2197308 0.765 rs11182434 chr12:37923968 C/A cg26384229 chr12:38710491 ALG10B 0.67 8.88 0.44 4.54e-17 Morning vs. evening chronotype; CRC cis rs7914558 1.000 rs12255047 chr10:104760752 G/A cg04362960 chr10:104952993 NT5C2 0.61 9.24 0.45 3.24e-18 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg11837864 chr2:220043521 FAM134A 0.5 6.8 0.35 4.82e-11 Thyroid stimulating hormone; CRC cis rs6764363 0.733 rs193071 chr3:294358 A/C cg02057681 chr3:285234 CHL1 -0.36 -5.94 -0.31 7.14e-9 Sudden cardiac arrest; CRC cis rs2836950 0.565 rs2150413 chr21:40614878 C/T cg11644478 chr21:40555479 PSMG1 -0.46 -6.69 -0.35 9.71e-11 Menarche (age at onset); CRC trans rs7615952 0.932 rs7630077 chr3:125649676 T/C cg00769240 chr8:12517080 NA -0.54 -6.72 -0.35 8.02e-11 Blood pressure (smoking interaction); CRC cis rs4243830 0.850 rs12563717 chr1:6599557 T/G cg05709478 chr1:6581295 PLEKHG5 0.56 6.08 0.32 3.27e-9 Body mass index; CRC cis rs10504229 0.953 rs59265461 chr8:58189701 A/T cg05313129 chr8:58192883 C8orf71 -0.47 -6.99 -0.36 1.49e-11 Developmental language disorder (linguistic errors); CRC cis rs172166 0.637 rs1225597 chr6:28162087 C/T cg03623178 chr6:28175578 NA 0.86 13.64 0.6 7.14e-34 Cardiac Troponin-T levels; CRC cis rs4665809 0.590 rs9309474 chr2:26448830 T/A cg04944784 chr2:26401820 FAM59B -0.83 -10.74 -0.51 2.96e-23 Gut microbiome composition (summer); CRC cis rs2802369 1 rs2802369 chr10:80960828 C/A cg18737081 chr10:80999807 ZMIZ1 -0.34 -6.03 -0.32 4.52e-9 Response to methotrexate in juvenile idiopathic arthritis; CRC cis rs1568889 0.838 rs11030185 chr11:28041904 C/T cg06544937 chr11:28130018 METT5D1;KIF18A 0.93 15.64 0.65 1.34e-41 Bipolar disorder; CRC cis rs172166 0.694 rs1150666 chr6:28123928 T/C cg02683197 chr6:28174875 NA 0.7 9.75 0.47 6.54e-20 Cardiac Troponin-T levels; CRC cis rs11690935 0.550 rs62183801 chr2:172867475 G/A cg13550731 chr2:172543902 DYNC1I2 0.61 8.8 0.44 7.61e-17 Schizophrenia; CRC trans rs17685 0.712 rs4732578 chr7:75721532 A/G cg19862616 chr7:65841803 NCRNA00174 0.99 18.51 0.71 6.2e-53 Coffee consumption;Coffee consumption (cups per day); CRC cis rs73206853 0.688 rs55805203 chr12:110819142 G/T cg12870014 chr12:110450643 ANKRD13A 0.78 7.41 0.38 1.07e-12 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC cis rs9467773 1.000 rs6940053 chr6:26562122 C/T cg09904177 chr6:26538194 HMGN4 0.85 14.85 0.63 1.61e-38 Intelligence (multi-trait analysis); CRC cis rs7769051 0.522 rs57176306 chr6:133142168 C/T cg07930552 chr6:133119739 C6orf192 0.73 6.08 0.32 3.38e-9 Type 2 diabetes nephropathy; CRC cis rs6500602 0.627 rs860891 chr16:4586529 C/T cg08645402 chr16:4508243 NA -0.58 -9.69 -0.47 1.08e-19 Schizophrenia; CRC cis rs1953600 0.870 rs2245168 chr10:81921918 T/C cg04850286 chr10:81895943 PLAC9 -0.38 -6.8 -0.35 4.94e-11 Sarcoidosis; CRC cis rs877282 0.583 rs10904566 chr10:821662 C/G cg17470449 chr10:769945 NA 0.58 7.88 0.4 4.89e-14 Uric acid levels; CRC cis rs4363385 0.747 rs946099 chr1:152971618 A/G cg25856811 chr1:152973957 SPRR3 -0.25 -6.79 -0.35 5.33e-11 Inflammatory skin disease; CRC cis rs72945132 0.660 rs67433166 chr11:70121604 T/A cg00319359 chr11:70116639 PPFIA1 0.68 7.5 0.38 6.05e-13 Coronary artery disease; CRC trans rs877282 0.945 rs71491311 chr10:791747 G/A cg22713356 chr15:30763199 NA 1.34 16.68 0.68 1.08e-45 Uric acid levels; CRC cis rs9487051 0.837 rs6568561 chr6:109592909 A/G cg21918786 chr6:109611834 NA -0.44 -8.03 -0.4 1.74e-14 Reticulocyte fraction of red cells; CRC cis rs9858542 0.953 rs9858280 chr3:49597737 T/C cg03060546 chr3:49711283 APEH -0.47 -6.51 -0.34 2.73e-10 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs9747201 0.926 rs7222764 chr17:80062698 G/A cg02741985 chr17:80059408 CCDC57 -0.43 -5.81 -0.31 1.46e-8 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs17345786 0.906 rs56171035 chr3:101111108 G/C cg11279151 chr3:101281821 RG9MTD1 -0.67 -8.41 -0.42 1.31e-15 Colonoscopy-negative controls vs population controls; CRC cis rs3804749 0.966 rs726681 chr3:122837648 C/T cg26084141 chr3:122786895 PDIA5 0.22 6.11 0.32 2.78e-9 Plateletcrit;Mean platelet volume;Platelet count;Platelet distribution width; CRC cis rs78456975 1.000 rs13429866 chr2:1555211 C/A cg12573674 chr2:1569213 NA -0.76 -7.84 -0.4 6.48e-14 Placebo response in major depressive disorder (% change in symptom score); CRC cis rs3760982 0.585 rs68073292 chr19:44291401 T/C cg11993925 chr19:44307056 LYPD5 0.58 10.26 0.49 1.35e-21 Breast cancer (estrogen-receptor negative);Breast cancer; CRC cis rs2033711 0.870 rs1465789 chr19:58946056 C/T cg13877915 chr19:58951672 ZNF132 0.48 7.57 0.39 3.85e-13 Uric acid clearance; CRC trans rs1979967 0.524 rs8034825 chr15:79655761 A/G cg14802097 chr12:42970349 PRICKLE1 0.51 6.02 0.31 4.69e-9 Interleukin-18 levels; CRC cis rs875971 1.000 rs7789554 chr7:65946038 A/G cg18912574 chr7:65842487 NCRNA00174 0.36 6.1 0.32 2.99e-9 Aortic root size; CRC cis rs4927850 1.000 rs7627868 chr3:195753473 A/T cg01181863 chr3:195395398 SDHAP2 -0.57 -8.0 -0.4 2.17e-14 Pancreatic cancer; CRC cis rs9469890 0.604 rs11758471 chr6:34503517 A/C cg17674042 chr6:34482479 PACSIN1 -0.63 -7.45 -0.38 8.35e-13 Pubertal anthropometrics;Coronary artery disease; CRC cis rs11098499 0.866 rs6857892 chr4:120282696 G/T cg09307838 chr4:120376055 NA 0.68 10.53 0.5 1.51e-22 Corneal astigmatism; CRC cis rs11711311 1.000 rs11711311 chr3:113430599 T/G cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.52 -6.97 -0.36 1.77e-11 IgG glycosylation; CRC cis rs9322193 0.923 rs9322214 chr6:150025122 C/T cg04369109 chr6:150039330 LATS1 -0.42 -5.63 -0.3 3.89e-8 Lung cancer; CRC cis rs3749237 0.615 rs11130202 chr3:49566715 C/T cg07636037 chr3:49044803 WDR6 0.55 8.01 0.4 2.07e-14 Resting heart rate; CRC cis rs8180040 0.653 rs6808742 chr3:47051512 G/A cg10298567 chr3:47292165 KIF9 -0.37 -5.88 -0.31 1.01e-8 Colorectal cancer; CRC cis rs6952808 0.582 rs871925 chr7:2047875 G/A cg21782813 chr7:2030301 MAD1L1 -0.45 -8.23 -0.41 4.4e-15 Bipolar disorder and schizophrenia; CRC cis rs965469 0.947 rs6051692 chr20:3244098 T/C cg25506879 chr20:3388711 C20orf194 -0.38 -5.68 -0.3 2.94e-8 IFN-related cytopenia; CRC cis rs6933660 0.721 rs2128945 chr6:151767907 A/G cg10883421 chr6:151773342 RMND1;C6orf211 0.79 13.76 0.6 2.45e-34 Menarche (age at onset); CRC cis rs514406 0.825 rs6693210 chr1:53223398 A/G cg24675658 chr1:53192096 ZYG11B 0.53 7.8 0.39 8.34e-14 Monocyte count; CRC cis rs780094 0.544 rs780110 chr2:27685388 G/A cg24768116 chr2:27665128 KRTCAP3 -0.33 -7.53 -0.38 4.79e-13 Calcium levels;Fasting blood insulin;Metabolic traits;Triglyceride levels;Fasting plasma glucose;Urate levels in overweight individuals;Urate levels in obese individuals;Uric acid levels;Height;Age-related diseases, mortality and associated endophenotypes;Renal underexcretion gout;Fasting blood glucose (BMI interaction);Urate levels;Gondoic acid (20:1n-9) levels;Fasting blood insulin (BMI interaction);Triglycerides;Plasma omega-3 polyunsaturated fatty acid levels (docosapentaenoic acid);Type 2 diabetes;Nonalcoholic fatty liver disease;Hypertriglyceridemia;C-reactive protein;Age-related disease endophenotypes;LDL cholesterol;Metabolic syndrome;Crohn's disease;Alcohol consumption (drinks per week);Homeostasis model assessment of insulin resistance;Alcohol consumption;Red blood cell count;Fasting blood glucose; CRC cis rs9929218 0.529 rs8059194 chr16:68749663 C/T cg01251360 chr16:68772225 CDH1 -0.23 -5.68 -0.3 2.91e-8 Colorectal cancer; CRC cis rs9902453 1.000 rs8065059 chr17:28417376 T/C cg26525008 chr17:28256777 EFCAB5;SSH2 -0.58 -8.6 -0.43 3.27e-16 Coffee consumption (cups per day); CRC cis rs41005 1.000 rs41003 chr2:8111772 A/C cg03155496 chr2:8117019 LOC339788 0.4 7.11 0.36 7.35e-12 Response to anti-TNF therapy in rheumatoid arthritis; CRC cis rs5753618 0.583 rs5749268 chr22:31809152 G/A cg22777020 chr22:31556080 RNF185 0.53 6.25 0.33 1.25e-9 Colorectal cancer; CRC cis rs875971 0.798 rs7789615 chr7:65878661 A/G cg18252515 chr7:66147081 NA -0.42 -5.99 -0.31 5.64e-9 Aortic root size; CRC cis rs2836974 0.965 rs8130984 chr21:40639966 A/C cg06238570 chr21:40685208 BRWD1 0.79 10.89 0.51 8.5e-24 Cognitive function; CRC cis rs4604732 0.578 rs79203328 chr1:247626581 C/G cg12754571 chr1:247694271 LOC148824;OR2C3 0.41 5.78 0.3 1.74e-8 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CRC cis rs17711722 0.522 rs4642526 chr7:65216742 G/T cg07294406 chr7:64700536 NA 0.35 5.69 0.3 2.87e-8 Calcium levels; CRC trans rs9858542 0.953 rs6997 chr3:49453834 C/T cg21582582 chr3:182698605 DCUN1D1 -0.51 -6.42 -0.33 4.73e-10 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs12791968 0.917 rs11038238 chr11:45002010 A/G cg11846598 chr11:44996168 LOC221122 -0.72 -12.82 -0.58 8.7e-31 Inhibitory control; CRC cis rs9928842 0.765 rs6564220 chr16:75224194 T/C cg09066997 chr16:75300724 BCAR1 0.65 6.14 0.32 2.33e-9 Alcoholic chronic pancreatitis; CRC cis rs9916302 0.851 rs6503518 chr17:37660469 A/G cg03013999 chr17:37608204 MED1 0.45 6.87 0.35 3.22e-11 Glomerular filtration rate (creatinine); CRC cis rs6951245 1.000 rs74366004 chr7:1088630 A/C cg21664854 chr7:1097933 C7orf50;GPR146 0.79 8.71 0.43 1.52e-16 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs12142240 0.698 rs17361887 chr1:46834775 A/G cg14993813 chr1:46806288 NSUN4 -0.49 -6.21 -0.32 1.56e-9 Menopause (age at onset); CRC cis rs5757676 0.858 rs6001585 chr22:39812986 G/T cg05872129 chr22:39784769 NA -0.47 -6.94 -0.36 2.05e-11 IgG glycosylation; CRC cis rs6964587 1.000 rs2301559 chr7:91746727 T/C cg17063962 chr7:91808500 NA 0.83 14.57 0.63 1.95e-37 Breast cancer; CRC cis rs9905704 0.918 rs444393 chr17:56709222 A/G cg12560992 chr17:57184187 TRIM37 0.56 7.64 0.39 2.46e-13 Testicular germ cell tumor; CRC cis rs4555082 0.874 rs2015978 chr14:105720134 G/C cg13114125 chr14:105738426 BRF1 -0.82 -11.99 -0.55 1.01e-27 Mean platelet volume;Platelet distribution width; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg14886145 chr10:74451829 CCDC109A 0.44 6.37 0.33 6.24e-10 Intelligence (multi-trait analysis); CRC cis rs2204008 0.837 rs12581130 chr12:38319387 A/G cg13010199 chr12:38710504 ALG10B 0.47 6.33 0.33 8.02e-10 Bladder cancer; CRC cis rs8066384 1 rs8066384 chr17:78625756 T/C cg16591659 chr17:78472290 NA -0.41 -6.09 -0.32 3.1e-9 Schizophrenia; CRC cis rs9443645 0.901 rs6940637 chr6:79705845 C/T cg11833968 chr6:79620685 NA -0.36 -6.15 -0.32 2.27e-9 Intelligence (multi-trait analysis); CRC cis rs9372498 0.536 rs55697388 chr6:118891544 C/T cg22561889 chr6:118971681 C6orf204 0.5 6.39 0.33 5.81e-10 Diastolic blood pressure; CRC cis rs561341 1.000 rs535151 chr17:30317405 C/T cg12193833 chr17:30244370 NA -0.57 -8.0 -0.4 2.11e-14 Hip circumference adjusted for BMI; CRC cis rs13108904 0.870 rs13124876 chr4:1247955 T/C cg23123621 chr4:1343375 KIAA1530 0.32 5.68 0.3 2.92e-8 Obesity-related traits; CRC cis rs853679 0.513 rs13437444 chr6:28070998 C/T cg25164649 chr6:28176230 NA 0.72 7.25 0.37 2.94e-12 Depression; CRC cis rs4925540 0.724 rs4971301 chr1:247172140 G/C cg22502715 chr1:247171572 ZNF695 0.41 6.07 0.32 3.46e-9 Response to taxane treatment (docetaxel); CRC cis rs6674970 1.000 rs61819219 chr1:151084375 C/G cg11822372 chr1:151115635 SEMA6C 0.53 7.59 0.39 3.39e-13 Childhood ear infection; CRC cis rs3008870 0.916 rs2025608 chr1:67422550 C/T cg08660285 chr1:67390436 MIER1;WDR78 1.02 15.1 0.64 1.6e-39 Lymphocyte percentage of white cells; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg06431905 chr5:148931119 CSNK1A1 0.41 6.49 0.34 3.23e-10 Liver disease severity in Alagille syndrome; CRC cis rs965469 1.000 rs6037579 chr20:3347980 G/A cg25506879 chr20:3388711 C20orf194 -0.39 -5.62 -0.3 4.02e-8 IFN-related cytopenia; CRC cis rs13256369 0.901 rs12681327 chr8:8566414 G/T cg06636001 chr8:8085503 FLJ10661 0.47 5.8 0.3 1.53e-8 Obesity-related traits; CRC cis rs3809566 1.000 rs4775612 chr15:63332157 T/C cg05507819 chr15:63340323 TPM1 0.45 6.87 0.35 3.22e-11 Platelet count; CRC cis rs6840360 1.000 rs2840130 chr4:152600699 T/C cg09659197 chr4:152720779 NA 0.5 10.63 0.51 6.99e-23 Intelligence (multi-trait analysis); CRC cis rs7917772 0.582 rs10786682 chr10:104318322 A/C cg11453585 chr10:104263688 ACTR1A;SUFU -0.83 -15.22 -0.64 5.69e-40 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC cis rs7119 0.717 rs12898370 chr15:77808598 A/T cg27398640 chr15:77910606 LINGO1 -0.43 -7.29 -0.37 2.32e-12 Type 2 diabetes; CRC cis rs6952808 0.760 rs11764960 chr7:1950532 G/A cg04267008 chr7:1944627 MAD1L1 -0.83 -12.36 -0.56 4.47e-29 Bipolar disorder and schizophrenia; CRC cis rs7605827 0.930 rs6431706 chr2:15600019 C/T cg19274914 chr2:15703543 NA 0.39 5.96 0.31 6.58e-9 Educational attainment (years of education); CRC cis rs7811142 0.830 rs73401450 chr7:99981859 G/C cg00814883 chr7:100076585 TSC22D4 -0.7 -8.63 -0.43 2.57e-16 Platelet count; CRC cis rs3087591 0.683 rs2040792 chr17:29628549 G/T cg24425628 chr17:29625626 OMG;NF1 0.7 12.79 0.58 1.13e-30 Hip circumference; CRC cis rs13108904 0.901 rs13119532 chr4:1304505 G/C cg00684032 chr4:1343700 KIAA1530 0.43 6.27 0.33 1.15e-9 Obesity-related traits; CRC cis rs2072499 0.833 rs2251636 chr1:156202809 G/C cg24450063 chr1:156163899 SLC25A44 1.04 21.13 0.76 3.18e-63 Testicular germ cell tumor; CRC cis rs908922 0.924 rs6669608 chr1:152475233 A/G cg23254163 chr1:152506842 NA 0.38 6.55 0.34 2.28e-10 Hair morphology; CRC cis rs6089829 0.962 rs2277769 chr20:61666805 C/T cg08564027 chr20:61660810 NA 0.82 15.1 0.64 1.61e-39 Prostate cancer (SNP x SNP interaction); CRC cis rs7772486 0.641 rs2253757 chr6:146199686 C/T cg13319975 chr6:146136371 FBXO30 -0.64 -9.23 -0.45 3.5e-18 Lobe attachment (rater-scored or self-reported); CRC cis rs1862618 0.853 rs252919 chr5:56124111 T/C cg24531977 chr5:56204891 C5orf35 -0.8 -10.88 -0.51 9.63e-24 Initial pursuit acceleration; CRC cis rs1215050 0.791 rs783959 chr4:98893476 C/T cg05340658 chr4:99064831 C4orf37 -0.5 -7.51 -0.38 5.79e-13 Waist-to-hip ratio adjusted for body mass index; CRC cis rs7677751 0.806 rs17084051 chr4:55087581 C/A cg00691999 chr4:55094011 PDGFRA 0.45 6.47 0.34 3.57e-10 Corneal astigmatism; CRC cis rs72781680 0.716 rs2712071 chr2:23990419 A/G cg08917208 chr2:24149416 ATAD2B 0.58 6.47 0.34 3.49e-10 Lymphocyte counts; CRC cis rs9486719 0.947 rs12194971 chr6:96911073 T/C cg06623918 chr6:96969491 KIAA0776 -0.79 -9.08 -0.45 1.04e-17 Migraine;Coronary artery disease; CRC cis rs7666738 0.830 rs6825211 chr4:98807698 A/T cg05340658 chr4:99064831 C4orf37 0.55 8.16 0.41 7.26e-15 Colonoscopy-negative controls vs population controls; CRC cis rs9659323 0.931 rs113197996 chr1:119522426 G/A cg26570165 chr1:119541833 NA -0.37 -6.21 -0.32 1.64e-9 Body mass index; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg10524192 chr9:34637478 SIGMAR1 0.47 6.6 0.34 1.66e-10 Anxiety disorder; CRC cis rs4660306 0.961 rs937290 chr1:45961955 A/G cg03123370 chr1:45965343 CCDC163P;MMACHC -0.56 -7.81 -0.4 7.95e-14 Homocysteine levels; CRC cis rs9291683 0.530 rs11723591 chr4:9985398 T/A cg00071950 chr4:10020882 SLC2A9 0.63 11.49 0.54 6.33e-26 Bone mineral density; CRC cis rs3924048 0.547 rs72642661 chr1:12612873 C/G cg00291366 chr1:12616550 NA 0.59 10.73 0.51 3.06e-23 Optic cup area; CRC cis rs4722166 0.597 rs1554606 chr7:22768707 T/G cg05472934 chr7:22766657 IL6 0.69 11.6 0.54 2.49e-26 Lung cancer; CRC cis rs736408 0.812 rs2240920 chr3:52831009 A/G cg10802521 chr3:52805072 NEK4 0.48 6.8 0.35 4.98e-11 Bipolar disorder; CRC cis rs9649465 0.561 rs609953 chr7:123422444 T/A cg03229431 chr7:123269106 ASB15 0.59 9.57 0.47 2.62e-19 Migraine; CRC cis rs870825 0.698 rs72703549 chr4:185623963 T/C cg04058563 chr4:185651563 MLF1IP 0.72 9.38 0.46 1.12e-18 Blood protein levels; CRC cis rs9309711 0.698 rs9750503 chr2:3491772 A/G cg10845886 chr2:3471009 TTC15 0.71 11.12 0.52 1.28e-24 Neurofibrillary tangles; CRC cis rs7249142 0.549 rs3787040 chr19:19297292 A/G cg26504305 chr19:19281019 LOC729991-MEF2B;MEF2B -0.4 -8.16 -0.41 7.25e-15 IgG glycosylation; CRC cis rs7647973 0.925 rs4955439 chr3:49245645 G/T cg07690219 chr3:49449608 TCTA;RHOA 0.51 5.79 0.3 1.64e-8 Menarche (age at onset); CRC cis rs972578 1.000 rs2284098 chr22:43401772 A/G cg01576275 chr22:43409880 NA -0.49 -8.14 -0.41 8.5e-15 Mean platelet volume; CRC cis rs7635838 0.684 rs2594966 chr3:11325276 A/G cg00170343 chr3:11313890 ATG7 -0.48 -7.36 -0.38 1.47e-12 HDL cholesterol; CRC trans rs10802346 0.545 rs2362252 chr1:246371574 A/C cg13514129 chr1:39547527 MACF1 0.65 9.87 0.48 2.72e-20 Fractional exhaled nitric oxide (childhood); CRC cis rs1008375 0.931 rs2098151 chr4:17577490 T/C cg02297831 chr4:17616191 MED28 0.44 5.73 0.3 2.3e-8 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs3733585 0.673 rs4455410 chr4:9953297 C/T cg00071950 chr4:10020882 SLC2A9 0.54 9.52 0.46 3.89e-19 Cleft plate (environmental tobacco smoke interaction); CRC cis rs853679 0.760 rs9357067 chr6:28210293 C/G cg15845792 chr6:28175446 NA 0.74 7.78 0.39 9.45e-14 Depression; CRC cis rs754466 0.580 rs11002301 chr10:79574078 G/A cg17075019 chr10:79541650 NA -0.98 -19.23 -0.73 8.84e-56 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs13064411 0.735 rs6438157 chr3:113207316 G/T cg18753928 chr3:113234510 CCDC52 -0.7 -10.83 -0.51 1.45e-23 Response to simvastatin treatment (PCSK9 protein level change); CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg03341697 chr11:94277138 FUT4 0.47 5.99 0.31 5.56e-9 Thyroid stimulating hormone; CRC cis rs2032447 0.507 rs199748 chr6:25909045 C/G cg03264133 chr6:25882463 NA -0.77 -10.93 -0.52 6.15e-24 Intelligence (multi-trait analysis); CRC cis rs11645898 0.935 rs4788615 chr16:72192372 G/A cg14768367 chr16:72042858 DHODH -0.58 -6.45 -0.34 3.96e-10 Blood protein levels; CRC cis rs11098499 0.754 rs10213267 chr4:120239074 A/G cg09307838 chr4:120376055 NA 0.62 9.75 0.47 6.92e-20 Corneal astigmatism; CRC cis rs67981189 0.529 rs8181986 chr14:71582244 G/A cg15910301 chr14:71632612 NA 0.31 6.06 0.32 3.78e-9 Schizophrenia; CRC cis rs9910055 0.530 rs2269907 chr17:42294215 G/A cg10896456 chr17:42255109 ASB16;C17orf65 0.34 5.88 0.31 1.02e-8 Total body bone mineral density; CRC cis rs4713675 0.565 rs60704560 chr6:33713300 C/T cg14003231 chr6:33640908 ITPR3 0.46 7.5 0.38 6.17e-13 Plateletcrit; CRC cis rs853679 1.000 rs68141011 chr6:28217797 G/T cg06470822 chr6:28175283 NA 0.69 6.48 0.34 3.33e-10 Depression; CRC cis rs11166629 1.000 rs4909330 chr8:135644369 T/C cg27224718 chr8:135614730 ZFAT 0.52 7.68 0.39 1.82e-13 Smoking quantity; CRC cis rs7223966 1.000 rs8074771 chr17:61735865 C/T cg05941027 chr17:61774174 LIMD2 0.37 6.71 0.35 8.59e-11 Hip circumference adjusted for BMI;Body mass index; CRC cis rs35771425 0.619 rs6689078 chr1:211476423 C/G cg25617285 chr1:211431773 RCOR3 -0.39 -5.61 -0.3 4.39e-8 Educational attainment (years of education); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg27583997 chr6:64346064 NA 0.43 5.96 0.31 6.38e-9 Response to antipsychotic treatment; CRC cis rs2404602 0.536 rs1587381 chr15:76769620 G/A cg03037974 chr15:76606532 NA 0.66 11.45 0.53 8.74e-26 Blood metabolite levels; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg23365554 chr19:54975006 LENG9 0.42 5.98 0.31 5.7e-9 Response to antipsychotic treatment; CRC cis rs2976388 0.609 rs2585153 chr8:143785345 G/A cg20041105 chr8:143859282 LYNX1 0.46 8.2 0.41 5.52e-15 Urinary tract infection frequency; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg05902063 chr12:96794315 CDK17 0.34 6.1 0.32 2.94e-9 Liver disease severity in Alagille syndrome; CRC cis rs9443645 0.869 rs6926537 chr6:79554193 T/A cg11833968 chr6:79620685 NA -0.36 -6.37 -0.33 6.31e-10 Intelligence (multi-trait analysis); CRC cis rs2836950 0.565 rs7276046 chr21:40581293 T/C cg17971929 chr21:40555470 PSMG1 -0.59 -8.65 -0.43 2.38e-16 Menarche (age at onset); CRC cis rs6496667 0.865 rs12592226 chr15:90926190 C/T cg04176472 chr15:90893244 GABARAPL3 0.58 7.51 0.38 5.73e-13 Rheumatoid arthritis; CRC cis rs7258465 1.000 rs10164323 chr19:18569492 C/T cg10790698 chr19:18539756 SSBP4 -0.46 -8.81 -0.44 7.26e-17 Breast cancer; CRC cis rs4481887 1.000 rs6697863 chr1:248495588 G/A cg00666640 chr1:248458726 OR2T12 0.55 9.38 0.46 1.1e-18 Common traits (Other); CRC trans rs637571 0.510 rs3903072 chr11:65583066 G/T cg17712092 chr4:129076599 LARP1B -0.49 -7.33 -0.37 1.77e-12 Eosinophil percentage of white cells; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg00218620 chr2:219866460 MIR375 0.42 6.95 0.36 1.93e-11 Liver disease severity in Alagille syndrome; CRC cis rs7610312 0.681 rs7610449 chr3:58319958 G/A cg06643156 chr3:58380774 PXK -0.39 -5.63 -0.3 3.78e-8 Red blood cell count; CRC cis rs4664308 0.935 rs17216980 chr2:160960932 G/A cg03641300 chr2:160917029 PLA2R1 -0.74 -12.27 -0.56 9.46e-29 Idiopathic membranous nephropathy; CRC cis rs10791323 0.538 rs1105494 chr11:133698733 A/C cg00579200 chr11:133705235 NA 0.41 5.83 0.31 1.29e-8 Childhood ear infection; CRC cis rs501120 0.584 rs11238925 chr10:44703730 A/G cg09554077 chr10:44749378 NA 0.67 7.47 0.38 7.27e-13 Coronary artery disease;Coronary heart disease; CRC cis rs780096 0.546 rs1104 chr2:27599875 T/G cg12000995 chr2:27665139 KRTCAP3 -0.3 -6.17 -0.32 2.03e-9 Total body bone mineral density; CRC cis rs853679 0.517 rs9283884 chr6:28135660 C/G cg02683197 chr6:28174875 NA -0.87 -10.47 -0.5 2.53e-22 Depression; CRC cis rs311392 0.902 rs411839 chr8:55092189 T/C cg06042504 chr8:55087323 NA -0.44 -6.86 -0.35 3.42e-11 Pelvic organ prolapse (moderate/severe); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg05790999 chr2:20850809 HS1BP3 0.38 6.11 0.32 2.86e-9 Liver disease severity in Alagille syndrome; CRC cis rs710865 0.516 rs12062540 chr1:19529204 A/G cg13387374 chr1:19411106 UBR4 0.46 7.44 0.38 8.89e-13 Brain structure; CRC cis rs1957429 0.808 rs4902325 chr14:65330843 A/G cg23373153 chr14:65346875 NA -0.63 -6.5 -0.34 2.97e-10 Pediatric areal bone mineral density (radius); CRC cis rs6951245 0.572 rs73265911 chr7:1055363 G/A cg26224354 chr7:1096374 C7orf50;GPR146 -0.55 -5.92 -0.31 8.08e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs1538970 1.000 rs4660853 chr1:45849090 C/T cg05343316 chr1:45956843 TESK2 0.66 8.79 0.44 8.33e-17 Platelet count; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg26303861 chr1:20988122 DDOST 0.38 6.02 0.31 4.65e-9 Liver disease severity in Alagille syndrome; CRC cis rs10504229 1.000 rs56168206 chr8:58184485 G/A cg24829409 chr8:58192753 C8orf71 -0.68 -11.34 -0.53 2.27e-25 Developmental language disorder (linguistic errors); CRC cis rs9322193 1.000 rs9377229 chr6:149928791 C/T cg07701084 chr6:150067640 NUP43 0.46 6.55 0.34 2.2e-10 Lung cancer; CRC cis rs801193 1.000 rs2659912 chr7:66157999 G/C cg05627663 chr7:65219948 SNORA22;CCT6P1 0.43 6.27 0.33 1.13e-9 Aortic root size; CRC cis rs6860806 0.661 rs3763112 chr5:131586480 A/G cg09877947 chr5:131593287 PDLIM4 0.46 8.47 0.42 8.27e-16 Breast cancer; CRC trans rs11098499 0.863 rs17050695 chr4:120489527 G/T cg25214090 chr10:38739885 LOC399744 0.61 9.58 0.47 2.38e-19 Corneal astigmatism; CRC cis rs3820928 0.874 rs13430941 chr2:227904447 G/A cg11843606 chr2:227700838 RHBDD1 -0.38 -5.63 -0.3 3.87e-8 Pulmonary function; CRC trans rs11026407 0.967 rs7127246 chr11:22060228 C/G cg23088508 chr4:20729211 PACRGL -0.54 -6.11 -0.32 2.85e-9 Plasma thyroid-stimulating hormone levels; CRC trans rs2797160 1.000 rs1630556 chr6:126013155 A/G cg05039488 chr6:79577232 IRAK1BP1 0.51 7.58 0.39 3.52e-13 Endometrial cancer; CRC cis rs3736594 0.759 rs6753736 chr2:27958855 C/G cg27432699 chr2:27873401 GPN1 -0.61 -8.41 -0.42 1.24e-15 Fasting blood glucose;Fasting blood glucose (BMI interaction); CRC cis rs1163251 0.837 rs517533 chr1:120229170 T/G cg19096424 chr1:120255104 PHGDH 0.42 6.11 0.32 2.89e-9 Blood metabolite levels; CRC cis rs748404 0.631 rs7163288 chr15:43671355 A/G cg02155558 chr15:43621948 ADAL;LCMT2 0.5 7.13 0.37 6.31e-12 Lung cancer; CRC cis rs10256972 0.621 rs2280725 chr7:1087426 G/T cg02869364 chr7:1081709 C7orf50 -0.43 -6.95 -0.36 1.95e-11 Longevity;Endometriosis; CRC cis rs7677751 0.806 rs7689569 chr4:55096398 G/A cg00691999 chr4:55094011 PDGFRA 0.42 5.98 0.31 5.69e-9 Corneal astigmatism; CRC cis rs875971 0.929 rs778692 chr7:65872449 A/G cg18912574 chr7:65842487 NCRNA00174 0.36 6.18 0.32 1.88e-9 Aortic root size; CRC trans rs2303319 0.504 rs62189046 chr2:162612371 C/G cg03774468 chr3:140950104 ACPL2 -0.65 -6.07 -0.32 3.61e-9 Cognitive function; CRC cis rs9682041 0.688 rs7621787 chr3:170146862 T/A cg11886554 chr3:170076028 SKIL 1.06 10.39 0.5 4.64e-22 Glomerular filtration rate in non diabetics (creatinine);Glomerular filtration rate (creatinine); CRC trans rs1941687 0.563 rs2032189 chr18:31332200 T/A cg27147174 chr7:100797783 AP1S1 -0.38 -6.25 -0.33 1.24e-9 Subjective well-being (multi-trait analysis);Subjective well-being; CRC trans rs1346081 0.786 rs1425645 chr4:68028175 C/T cg00127047 chr5:142150919 ARHGAP26 0.51 6.28 0.33 1.05e-9 Intelligence (multi-trait analysis); CRC cis rs1552244 0.882 rs3755782 chr3:10029305 T/C cg08888203 chr3:10149979 C3orf24 0.62 8.23 0.41 4.29e-15 Alzheimer's disease; CRC cis rs9658691 0.920 rs72809352 chr10:90742624 A/G cg03111039 chr10:90751583 FAS;ACTA2 -0.87 -6.3 -0.33 9.75e-10 Mosquito bite size; CRC cis rs6502050 0.835 rs67682841 chr17:80117745 T/C cg22110888 chr17:80059540 CCDC57 0.4 6.45 0.34 3.95e-10 Life satisfaction; CRC cis rs77861329 0.669 rs2878438 chr3:52103045 A/G cg08692210 chr3:52188851 WDR51A 0.54 6.35 0.33 7.31e-10 Macrophage inflammatory protein 1b levels; CRC cis rs7917772 0.636 rs7911747 chr10:104528890 A/G cg22532475 chr10:104410764 TRIM8 0.34 5.8 0.3 1.58e-8 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC cis rs4713118 0.516 rs7739216 chr6:28079946 G/T cg18032046 chr6:28092343 ZSCAN16 -0.52 -6.02 -0.32 4.59e-9 Parkinson's disease; CRC trans rs2324229 0.797 rs1180237 chr6:83943928 A/C cg18385501 chr17:73401976 GRB2 -0.43 -6.04 -0.32 4.17e-9 Platelet-derived growth factor BB levels; CRC cis rs2708977 0.692 rs17685766 chr2:97319534 G/C cg01950434 chr2:97203154 ARID5A 0.48 6.74 0.35 7.1e-11 Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes; CRC cis rs1008375 0.966 rs11722132 chr4:17697217 T/C cg16339924 chr4:17578868 LAP3 0.49 6.63 0.34 1.39e-10 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs651907 0.557 rs34624546 chr3:101374226 T/G cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.62 8.42 0.42 1.2e-15 Colorectal cancer; CRC cis rs4665809 0.590 rs10197494 chr2:26445550 A/G cg08067268 chr2:26466485 HADHB;HADHA -0.65 -8.34 -0.42 2e-15 Gut microbiome composition (summer); CRC cis rs6502050 0.805 rs4356529 chr17:80157797 A/G cg13198984 chr17:80129470 CCDC57 -0.45 -8.04 -0.41 1.63e-14 Life satisfaction; CRC cis rs2036402 1.000 rs12515585 chr5:156430150 A/G cg21915449 chr5:156456672 HAVCR1 -0.46 -5.62 -0.3 3.99e-8 Hypertriglyceridemia; CRC cis rs7811142 0.943 rs66958101 chr7:100074020 G/A cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.16 16.72 0.68 7.62e-46 Platelet count; CRC cis rs801193 0.636 rs2659895 chr7:66196471 C/A cg18876405 chr7:65276391 NA 0.51 8.35 0.42 1.88e-15 Aortic root size; CRC trans rs1814175 0.817 rs4881623 chr11:49804991 C/T cg03929089 chr4:120376271 NA -0.97 -18.93 -0.72 1.36e-54 Height; CRC cis rs2032447 0.520 rs198818 chr6:26125711 A/C cg03264133 chr6:25882463 NA 0.43 5.84 0.31 1.22e-8 Intelligence (multi-trait analysis); CRC cis rs10791323 0.660 rs10791332 chr11:133732150 A/G cg15485101 chr11:133734466 NA 0.44 8.08 0.41 1.28e-14 Childhood ear infection; CRC cis rs7786877 0.723 rs10487157 chr7:100214487 C/G cg00334542 chr7:100209784 MOSPD3 -0.68 -8.02 -0.4 1.83e-14 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs11971779 0.680 rs7792752 chr7:139066196 G/C cg23387468 chr7:139079360 LUC7L2 0.41 7.04 0.36 1.14e-11 Diisocyanate-induced asthma; CRC cis rs4073416 0.542 rs10145146 chr14:66075004 C/T cg03016385 chr14:66212404 NA -0.45 -6.17 -0.32 2.05e-9 N-glycan levels; CRC cis rs10128264 0.934 rs1250590 chr10:80983786 A/C cg18737081 chr10:80999807 ZMIZ1 0.38 6.75 0.35 6.52e-11 Response to methotrexate in juvenile idiopathic arthritis; CRC cis rs8031584 0.958 rs3512 chr15:31235005 G/C cg08704250 chr15:31115839 NA -0.44 -8.0 -0.4 2.15e-14 Huntington's disease progression; CRC trans rs2303319 0.504 rs35304298 chr2:162617185 G/T cg14875682 chr5:52083620 ITGA1;PELO -0.73 -6.12 -0.32 2.59e-9 Cognitive function; CRC cis rs9649213 0.593 rs56286037 chr7:98019522 C/T cg00277769 chr7:97922759 BAIAP2L1 -0.58 -10.04 -0.48 7.46e-21 Prostate cancer (SNP x SNP interaction); CRC cis rs7927771 0.826 rs7925389 chr11:47466790 A/T cg20307385 chr11:47447363 PSMC3 -0.63 -9.23 -0.45 3.36e-18 Subjective well-being; CRC cis rs28386778 0.897 rs2036911 chr17:61794839 A/T cg06873352 chr17:61820015 STRADA 0.79 14.73 0.63 4.42e-38 Prudent dietary pattern; CRC cis rs4363385 0.818 rs407448 chr1:153007504 C/T cg25856811 chr1:152973957 SPRR3 -0.27 -7.37 -0.38 1.43e-12 Inflammatory skin disease; CRC cis rs9911578 1.000 rs4398153 chr17:56968181 T/C cg12560992 chr17:57184187 TRIM37 -0.93 -16.81 -0.68 3.37e-46 Intelligence (multi-trait analysis); CRC trans rs1455244 0.700 rs7229302 chr18:11508904 G/T cg09423994 chr12:56660919 COQ10A 0.39 6.04 0.32 4.15e-9 Schizophrenia; CRC cis rs6502050 0.871 rs11870632 chr17:80075406 T/C cg02741985 chr17:80059408 CCDC57 -0.45 -7.4 -0.38 1.17e-12 Life satisfaction; CRC cis rs6901250 0.851 rs339322 chr6:117193356 T/C cg12892004 chr6:117198278 RFX6 -0.44 -6.92 -0.36 2.31e-11 C-reactive protein levels; CRC cis rs861020 0.606 rs4844903 chr1:210006267 C/T cg05527609 chr1:210001259 C1orf107 0.77 10.66 0.51 5.37e-23 Orofacial clefts; CRC cis rs2839186 0.934 rs13046494 chr21:47707430 A/C cg09417038 chr21:47716443 C21orf57 -0.42 -6.93 -0.36 2.21e-11 Testicular germ cell tumor; CRC cis rs6840360 0.573 rs7692939 chr4:152258455 C/T cg09659197 chr4:152720779 NA 0.33 6.47 0.34 3.45e-10 Intelligence (multi-trait analysis); CRC cis rs3796619 1.000 rs13146371 chr4:1082887 C/T cg27284194 chr4:1044797 NA 0.39 6.13 0.32 2.58e-9 Recombination rate (males); CRC cis rs9329221 0.527 rs10903328 chr8:10332167 G/C cg27411982 chr8:10470053 RP1L1 0.37 5.82 0.31 1.42e-8 Neuroticism; CRC cis rs3126085 0.935 rs4634913 chr1:152249932 T/C cg09127314 chr1:152161683 NA 0.46 5.85 0.31 1.17e-8 Atopic dermatitis; CRC cis rs11190604 1.000 rs7085439 chr10:102210100 C/T cg16342193 chr10:102329863 NA -0.35 -5.83 -0.31 1.29e-8 Palmitoleic acid (16:1n-7) levels; CRC cis rs763121 0.853 rs2235230 chr22:39124467 A/G cg06544989 chr22:39130855 UNC84B -0.45 -6.64 -0.34 1.32e-10 Menopause (age at onset); CRC cis rs62244186 0.683 rs6766334 chr3:44567065 T/C cg11003573 chr3:44754125 ZNF502 -0.33 -5.68 -0.3 2.97e-8 Depressive symptoms; CRC trans rs7604735 0.824 rs1881409 chr2:145821520 A/G cg26010734 chr19:15344046 EPHX3 -0.36 -6.25 -0.33 1.29e-9 Coronary artery disease; CRC cis rs1005277 0.541 rs1740741 chr10:38515334 C/T cg25427524 chr10:38739819 LOC399744 -0.79 -14.49 -0.62 3.78e-37 Extrinsic epigenetic age acceleration; CRC cis rs2197308 0.667 rs11181073 chr12:37898543 A/G cg26384229 chr12:38710491 ALG10B 0.65 8.97 0.44 2.25e-17 Morning vs. evening chronotype; CRC cis rs1046896 0.538 rs3803771 chr17:80687758 G/A cg16060761 chr17:80687452 NA 0.66 11.46 0.53 8.58e-26 Glycated hemoglobin levels; CRC cis rs7044106 0.762 rs4837789 chr9:123426256 G/A cg09419670 chr9:123605666 PSMD5;LOC253039 0.69 10.77 0.51 2.22e-23 Hip circumference adjusted for BMI; CRC cis rs4743820 0.651 rs73494917 chr9:93923120 T/G cg14446406 chr9:93919335 NA 0.81 14.88 0.63 1.24e-38 Ulcerative colitis;Inflammatory bowel disease; CRC cis rs2032447 0.839 rs199751 chr6:26015583 T/C cg18357526 chr6:26021779 HIST1H4A 0.79 12.04 0.55 6.69e-28 Intelligence (multi-trait analysis); CRC cis rs4713118 0.869 rs6914924 chr6:27711530 C/T cg12172441 chr6:28176163 NA 0.52 7.19 0.37 4.51e-12 Parkinson's disease; CRC cis rs4819052 0.851 rs2838840 chr21:46668494 A/G cg02159808 chr21:46707872 POFUT2;LOC642852 0.47 6.14 0.32 2.33e-9 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs13191362 0.507 rs2849527 chr6:163117932 G/T cg06582575 chr6:163149167 PACRG;PARK2 0.52 8.08 0.41 1.28e-14 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs926938 0.618 rs1286560 chr1:115375930 C/T cg12756093 chr1:115239321 AMPD1 -0.58 -8.49 -0.42 7.15e-16 Autism; CRC cis rs6546550 0.901 rs897120 chr2:70160982 C/T cg02498382 chr2:70120550 SNRNP27 0.56 9.68 0.47 1.19e-19 Prevalent atrial fibrillation; CRC cis rs9487051 0.872 rs1111864 chr6:109611138 A/G cg21918786 chr6:109611834 NA -0.44 -8.13 -0.41 8.67e-15 Reticulocyte fraction of red cells; CRC cis rs6951245 0.935 rs118132455 chr7:1068232 C/A cg24642844 chr7:1081250 C7orf50 -0.78 -9.35 -0.46 1.42e-18 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs11608355 0.846 rs4766472 chr12:109853602 C/G cg19025524 chr12:109796872 NA -0.45 -5.96 -0.31 6.61e-9 Neuroticism; CRC cis rs936229 0.813 rs2301249 chr15:75092384 T/C cg14664628 chr15:75095509 CSK -1.04 -21.1 -0.76 4.07e-63 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); CRC cis rs6665290 0.566 rs1513617 chr1:227447213 C/T cg10327440 chr1:227177885 CDC42BPA 0.73 11.63 0.54 1.98e-26 Myeloid white cell count; CRC cis rs6938 0.618 rs11633472 chr15:75184084 T/G cg17294928 chr15:75287854 SCAMP5 0.56 8.62 0.43 2.81e-16 Breast cancer; CRC cis rs9611565 0.659 rs12484228 chr22:41939739 A/G cg06634786 chr22:41940651 POLR3H -0.65 -7.62 -0.39 2.66e-13 Vitiligo; CRC cis rs2013441 1.000 rs2703802 chr17:20101039 T/C cg13482628 chr17:19912719 NA -0.41 -6.22 -0.32 1.48e-9 Obesity-related traits; CRC cis rs6504663 1.000 rs6504661 chr17:48580126 A/T cg03611598 chr17:48586076 MYCBPAP -0.43 -5.62 -0.3 4.05e-8 Visceral fat; CRC cis rs7635838 0.859 rs6779840 chr3:11425423 A/G cg00170343 chr3:11313890 ATG7 0.42 6.33 0.33 8.01e-10 HDL cholesterol; CRC cis rs9916302 0.706 rs12947506 chr17:37707592 A/G cg00129232 chr17:37814104 STARD3 -0.5 -6.18 -0.32 1.94e-9 Glomerular filtration rate (creatinine); CRC trans rs2303319 0.504 rs1515184 chr2:162561347 A/G cg12500891 chr11:57225987 NA -0.67 -6.03 -0.32 4.51e-9 Cognitive function; CRC cis rs477895 0.838 rs11607007 chr11:64007976 C/T cg19465662 chr11:63993652 NUDT22;TRPT1 0.77 9.11 0.45 8.31e-18 Mean platelet volume; CRC cis rs9325144 0.600 rs1817648 chr12:38733424 C/T cg26384229 chr12:38710491 ALG10B -0.54 -8.15 -0.41 7.48e-15 Morning vs. evening chronotype; CRC cis rs58688157 0.883 rs34793529 chr11:575800 T/G cg01842473 chr11:617407 IRF7;MUPCDH -0.63 -8.27 -0.41 3.35e-15 Systemic lupus erythematosus; CRC cis rs514406 0.792 rs1242201 chr1:53344748 G/A cg27535305 chr1:53392650 SCP2 -0.4 -7.18 -0.37 4.65e-12 Monocyte count; CRC cis rs7659604 0.967 rs34949254 chr4:122664344 G/A cg19748678 chr4:122722346 EXOSC9 0.55 8.92 0.44 3.38e-17 Type 2 diabetes; CRC cis rs10512697 0.655 rs13166953 chr5:3472213 A/G cg19473799 chr5:3511975 NA -0.83 -6.35 -0.33 7.32e-10 Immune response to smallpox vaccine (IL-6); CRC cis rs3820068 0.529 rs79570154 chr1:15990912 T/C cg24675056 chr1:15929824 NA 0.54 7.17 0.37 5.01e-12 Systolic blood pressure; CRC cis rs73206853 0.764 rs16940881 chr12:110937818 G/C cg12870014 chr12:110450643 ANKRD13A 0.84 9.78 0.47 5.3e-20 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC cis rs9303280 0.936 rs907091 chr17:37921742 A/G cg20243544 chr17:37824526 PNMT 0.44 6.83 0.35 4.21e-11 Self-reported allergy; CRC cis rs875971 1.000 rs875971 chr7:65617595 A/G cg12463550 chr7:65579703 CRCP -0.47 -6.84 -0.35 3.78e-11 Aortic root size; CRC cis rs10504229 0.683 rs6999351 chr8:58127227 C/T cg24829409 chr8:58192753 C8orf71 -0.55 -8.03 -0.4 1.71e-14 Developmental language disorder (linguistic errors); CRC cis rs2836974 0.584 rs7276774 chr21:40628725 T/G cg22974920 chr21:40686053 BRWD1 -0.42 -5.89 -0.31 9.39e-9 Cognitive function; CRC cis rs1008375 0.966 rs4235392 chr4:17696422 A/G cg16339924 chr4:17578868 LAP3 0.49 6.57 0.34 1.94e-10 Parasitemia in Tripanosoma cruzi seropositivity; CRC trans rs6600671 0.899 rs2319971 chr1:121226982 A/C cg00646200 chr1:148855367 NA 0.33 5.98 0.31 5.68e-9 Hip geometry; CRC cis rs6502050 0.835 rs4789666 chr17:80162276 C/T cg19223190 chr17:80058835 NA 0.43 6.93 0.36 2.16e-11 Life satisfaction; CRC cis rs3126085 0.935 rs3120660 chr1:152258701 G/T cg09127314 chr1:152161683 NA -0.45 -5.86 -0.31 1.14e-8 Atopic dermatitis; CRC cis rs1552244 0.816 rs13076197 chr3:10019773 T/C cg13047869 chr3:10149882 C3orf24 0.51 6.91 0.36 2.54e-11 Alzheimer's disease; CRC cis rs12926788 0.689 rs1862450 chr16:24856775 A/G cg06028605 chr16:24865363 SLC5A11 -0.43 -6.29 -0.33 1.03e-9 Ejection fraction in Tripanosoma cruzi seropositivity; CRC cis rs2898681 0.511 rs881743 chr4:53727450 A/G cg00338735 chr4:53728038 RASL11B 0.37 6.15 0.32 2.27e-9 Optic nerve measurement (cup area); CRC cis rs375066 0.935 rs396973 chr19:44399306 C/T cg12072164 chr19:44306565 LYPD5 -0.37 -5.68 -0.3 2.93e-8 Breast cancer; CRC cis rs4728302 0.869 rs13221033 chr7:133617487 T/A cg10665199 chr7:133106180 EXOC4 0.38 5.77 0.3 1.83e-8 Intelligence;Intelligence (multi-trait analysis); CRC cis rs7208859 0.623 rs73269988 chr17:29118145 G/A cg01831904 chr17:28903510 LRRC37B2 -0.62 -6.41 -0.33 5.13e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg23104823 chr14:45553408 PRPF39 0.5 7.24 0.37 3.18e-12 Response to antipsychotic treatment; CRC cis rs6964587 0.692 rs10227225 chr7:91571074 A/G cg17063962 chr7:91808500 NA -0.62 -9.92 -0.48 1.77e-20 Breast cancer; CRC cis rs3741151 1.000 rs79038783 chr11:73038746 C/G cg17517138 chr11:73019481 ARHGEF17 1.11 9.49 0.46 4.91e-19 GIP levels in response to oral glucose tolerance test (120 minutes); CRC cis rs1448094 0.737 rs10863135 chr12:86382657 C/T cg02569458 chr12:86230093 RASSF9 0.4 6.78 0.35 5.53e-11 Major depressive disorder; CRC cis rs853679 0.517 rs9357066 chr6:28129831 T/C cg25164649 chr6:28176230 NA 0.78 9.66 0.47 1.33e-19 Depression; CRC cis rs9894429 0.966 rs6565604 chr17:79589242 G/A cg21028142 chr17:79581711 NPLOC4 0.39 8.62 0.43 2.79e-16 Eye color traits; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg24865406 chr1:230203041 GALNT2 0.36 5.97 0.31 6.06e-9 Liver disease severity in Alagille syndrome; CRC cis rs9902453 0.967 rs1042173 chr17:28525011 A/C cg26525008 chr17:28256777 EFCAB5;SSH2 0.6 9.35 0.46 1.35e-18 Coffee consumption (cups per day); CRC cis rs4665809 0.549 rs3828255 chr2:26413252 G/A cg27170947 chr2:26402098 FAM59B 0.67 8.07 0.41 1.36e-14 Gut microbiome composition (summer); CRC cis rs8014671 0.553 rs2877661 chr14:70916559 G/T cg25576086 chr14:70833871 SYNJ2BP -0.34 -5.81 -0.31 1.46e-8 Prostate cancer; CRC cis rs9549328 0.544 rs66893681 chr13:113617499 A/G cg24588162 chr13:113633484 MCF2L 0.36 6.52 0.34 2.68e-10 Systolic blood pressure; CRC cis rs4663969 0.541 rs11902131 chr2:234594269 C/T cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.48 -7.45 -0.38 8.03e-13 Total bilirubin levels in HIV-1 infection; CRC cis rs9915657 0.773 rs9894696 chr17:70099487 C/T cg09344028 chr17:70110421 NA 0.51 8.36 0.42 1.78e-15 Thyroid hormone levels; CRC cis rs7487075 1.000 rs12832425 chr12:46822818 A/T cg22049899 chr12:47219821 SLC38A4 0.31 6.02 0.32 4.63e-9 Itch intensity from mosquito bite; CRC cis rs1448094 0.933 rs10779218 chr12:86320053 A/G cg02569458 chr12:86230093 RASSF9 0.37 6.42 0.33 4.74e-10 Major depressive disorder; CRC cis rs7945705 1.000 rs7937298 chr11:8867509 G/C cg00186954 chr11:8933980 ST5;C11orf17 0.44 6.6 0.34 1.66e-10 Hemoglobin concentration; CRC cis rs3824867 0.676 rs7104366 chr11:47462115 G/A cg05585544 chr11:47624801 NA -0.4 -6.35 -0.33 7.06e-10 Mean corpuscular hemoglobin; CRC cis rs3733585 0.624 rs76574510 chr4:9953252 T/A cg00071950 chr4:10020882 SLC2A9 -0.55 -9.74 -0.47 7.09e-20 Cleft plate (environmental tobacco smoke interaction); CRC cis rs17345786 1.000 rs997739 chr3:101313940 A/G cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.59 6.9 0.36 2.73e-11 Colonoscopy-negative controls vs population controls; CRC cis rs6088590 0.930 rs6120723 chr20:33364655 C/T cg24642439 chr20:33292090 TP53INP2 0.61 11.03 0.52 2.86e-24 Coronary artery disease; CRC cis rs2204008 0.744 rs11514071 chr12:38392076 C/T cg13010199 chr12:38710504 ALG10B 0.47 6.24 0.33 1.32e-9 Bladder cancer; CRC cis rs853679 0.517 rs9368551 chr6:28061792 A/G cg12273811 chr6:28175739 NA 0.74 9.41 0.46 8.58e-19 Depression; CRC cis rs9457247 0.565 rs12178491 chr6:167512474 C/T cg07513332 chr6:167530253 CCR6 0.36 5.65 0.3 3.42e-8 Crohn's disease; CRC cis rs9494145 0.567 rs35786788 chr6:135419042 G/A cg22676075 chr6:135203613 NA 0.57 7.19 0.37 4.42e-12 Mean platelet volume;Platelet count;Fetal hemoglobin levels in sickle cell anemia;Red blood cell traits; CRC cis rs394563 0.690 rs237010 chr6:149758750 G/T cg17885791 chr6:149771845 ZC3H12D -0.32 -5.77 -0.3 1.85e-8 Dupuytren's disease; CRC trans rs35110281 0.744 rs230644 chr21:44917183 C/T cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO -0.4 -6.18 -0.32 1.88e-9 Mean corpuscular volume; CRC trans rs2692947 0.644 rs2969491 chr2:96794982 C/T cg09070855 chr12:133302174 NA 0.4 6.08 0.32 3.4e-9 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; CRC cis rs1619661 0.530 rs1509929 chr10:44682829 A/C cg09554077 chr10:44749378 NA 0.47 7.12 0.37 6.99e-12 QT interval (ambient particulate matter interaction); CRC cis rs7312933 0.932 rs10880220 chr12:42383046 A/G cg11827402 chr12:42719852 PPHLN1;ZCRB1 0.61 7.96 0.4 2.75e-14 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CRC cis rs10504229 1.000 rs17805549 chr8:58179653 T/C cg24829409 chr8:58192753 C8orf71 -0.68 -11.34 -0.53 2.27e-25 Developmental language disorder (linguistic errors); CRC cis rs4819052 0.851 rs2838856 chr21:46680766 T/G cg02159808 chr21:46707872 POFUT2;LOC642852 0.5 6.79 0.35 5.33e-11 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs4718428 0.705 rs4718422 chr7:66359269 A/G cg12165864 chr7:66369176 NA -0.41 -5.67 -0.3 3.13e-8 Corneal structure; CRC cis rs972578 0.791 rs713776 chr22:43396094 A/G cg01576275 chr22:43409880 NA -0.39 -6.13 -0.32 2.48e-9 Mean platelet volume; CRC cis rs11958404 0.932 rs72816572 chr5:157429818 T/C cg05962755 chr5:157440814 NA 1.01 12.88 0.58 5.12e-31 IgG glycosylation; CRC cis rs4481887 1.000 rs7511706 chr1:248467360 G/A cg00666640 chr1:248458726 OR2T12 0.52 9.16 0.45 5.86e-18 Common traits (Other); CRC cis rs2842992 0.672 rs7738253 chr6:160193917 G/T cg19482086 chr6:160211437 TCP1;MRPL18 0.77 10.12 0.49 3.9e-21 Age-related macular degeneration (geographic atrophy); CRC cis rs11098499 0.874 rs17839089 chr4:120111069 A/G cg09307838 chr4:120376055 NA 0.61 8.95 0.44 2.69e-17 Corneal astigmatism; CRC cis rs7552404 1.000 rs437298 chr1:76113770 T/C cg03433033 chr1:76189801 ACADM -0.8 -11.03 -0.52 2.89e-24 Blood metabolite levels;Acylcarnitine levels; CRC cis rs4363385 0.818 rs11205164 chr1:152986023 A/T cg25856811 chr1:152973957 SPRR3 -0.24 -6.71 -0.35 8.61e-11 Inflammatory skin disease; CRC cis rs6952808 0.929 rs11768206 chr7:1932151 T/G cg04267008 chr7:1944627 MAD1L1 -0.82 -12.37 -0.56 4.14e-29 Bipolar disorder and schizophrenia; CRC cis rs6502050 0.835 rs6502069 chr17:80112599 G/T cg11859384 chr17:80120422 CCDC57 -0.37 -5.85 -0.31 1.16e-8 Life satisfaction; CRC trans rs2303319 0.504 rs62187571 chr2:162374319 A/G cg09481857 chr22:21368659 P2RX6;MGC16703 -0.64 -6.11 -0.32 2.75e-9 Cognitive function; CRC cis rs7595037 0.663 rs7421075 chr2:68656342 T/C cg12452813 chr2:68675892 NA -0.43 -6.38 -0.33 5.96e-10 Multiple sclerosis; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg25369027 chr8:103666178 KLF10 0.46 6.37 0.33 6.38e-10 Response to antipsychotic treatment; CRC trans rs9868809 0.881 rs6773261 chr3:48675064 A/G cg03060546 chr3:49711283 APEH -0.56 -6.14 -0.32 2.37e-9 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; CRC cis rs6743376 0.556 rs1530548 chr2:113817402 G/A cg09040174 chr2:113837401 NA 0.44 6.43 0.33 4.61e-10 Inflammatory biomarkers; CRC cis rs9787249 0.957 rs3738673 chr1:40204823 C/T cg24920358 chr1:40204285 PPIE 0.56 8.37 0.42 1.62e-15 Blood protein levels; CRC cis rs9392556 0.600 rs2326408 chr6:4119516 A/G cg10424681 chr6:4079350 C6orf201;C6orf146 0.24 5.92 0.31 8.27e-9 Blood metabolite levels; CRC cis rs7849270 0.959 rs2297111 chr9:131904294 G/A cg13538475 chr9:131942899 NA -0.31 -6.27 -0.33 1.15e-9 Blood metabolite ratios; CRC cis rs9467711 0.591 rs13207673 chr6:25901133 C/T cg16898833 chr6:26189333 HIST1H4D 0.79 6.8 0.35 5e-11 Autism spectrum disorder or schizophrenia; CRC cis rs1552244 0.935 rs6805869 chr3:10119917 T/C cg16606324 chr3:10149918 C3orf24 0.7 9.74 0.47 7.03e-20 Alzheimer's disease; CRC cis rs6762477 0.748 rs9831967 chr3:50217234 C/T cg05623727 chr3:50126028 RBM5 -0.45 -7.46 -0.38 7.82e-13 Menarche (age at onset); CRC cis rs11155671 0.530 rs7763849 chr6:150206380 C/T cg13206674 chr6:150067644 NUP43 0.48 6.82 0.35 4.48e-11 Testicular germ cell tumor; CRC cis rs9911578 0.967 rs11079368 chr17:57086473 C/T cg05425664 chr17:57184151 TRIM37 0.51 8.08 0.41 1.26e-14 Intelligence (multi-trait analysis); CRC cis rs9747201 1.000 rs56283054 chr17:80135326 C/T cg09264619 chr17:80180166 NA 0.49 6.97 0.36 1.73e-11 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs6433857 0.536 rs12474658 chr2:181352992 G/T cg23363182 chr2:181467187 NA -0.54 -8.13 -0.41 8.84e-15 Body mass index; CRC cis rs7107174 1.000 rs10793303 chr11:78060750 G/A cg02023728 chr11:77925099 USP35 0.5 7.61 0.39 2.92e-13 Testicular germ cell tumor; CRC cis rs13064411 0.518 rs1471883 chr3:113211828 C/T cg18753928 chr3:113234510 CCDC52 -0.48 -7.67 -0.39 2.01e-13 Response to simvastatin treatment (PCSK9 protein level change); CRC cis rs3820068 0.603 rs6695903 chr1:15985940 C/T cg17385448 chr1:15911702 AGMAT 0.29 5.84 0.31 1.22e-8 Systolic blood pressure; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg25568297 chr16:30077541 ALDOA 0.46 6.56 0.34 2.1e-10 Response to antipsychotic treatment; CRC cis rs2836974 0.899 rs34176878 chr21:40548855 C/A cg06238570 chr21:40685208 BRWD1 0.78 10.69 0.51 4.36e-23 Cognitive function; CRC cis rs7208859 0.673 rs2269915 chr17:29233344 C/T cg13385521 chr17:29058706 SUZ12P 0.69 7.93 0.4 3.48e-14 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs41271473 0.526 rs28593014 chr1:228743576 G/A cg16512390 chr1:228756714 NA 0.64 6.78 0.35 5.59e-11 Chronic lymphocytic leukemia; CRC cis rs853679 0.517 rs9348793 chr6:28084189 G/A cg23161317 chr6:28129485 ZNF389 0.54 6.56 0.34 2.12e-10 Depression; CRC cis rs3751196 0.708 rs55810720 chr12:104188770 A/G cg02344784 chr12:104178138 NT5DC3 0.69 7.05 0.36 1.06e-11 Sense of smell; CRC cis rs911555 0.755 rs1116095 chr14:103931879 A/G cg12935359 chr14:103987150 CKB 0.56 9.16 0.45 5.74e-18 Intelligence (multi-trait analysis); CRC cis rs4862750 0.872 rs6836781 chr4:187899701 G/A cg03647317 chr4:187891568 NA -0.54 -10.28 -0.49 1.09e-21 Lobe attachment (rater-scored or self-reported); CRC cis rs2652834 0.861 rs4774472 chr15:63353760 C/A cg05507819 chr15:63340323 TPM1 0.46 6.11 0.32 2.86e-9 HDL cholesterol; CRC trans rs7618501 0.521 rs55692411 chr3:49911155 G/A cg21665057 chr3:196295764 WDR53;FBXO45 0.54 7.93 0.4 3.38e-14 Intelligence (multi-trait analysis); CRC cis rs847577 0.609 rs7791463 chr7:97819047 G/A cg00277769 chr7:97922759 BAIAP2L1 -0.41 -6.88 -0.35 2.99e-11 Breast cancer; CRC cis rs1218582 0.741 rs11264291 chr1:154914797 C/T cg16680214 chr1:154839983 KCNN3 -0.42 -8.01 -0.4 2.06e-14 Prostate cancer; CRC cis rs782590 0.783 rs7594279 chr2:55812073 T/G cg18811423 chr2:55921094 PNPT1 0.79 14.51 0.62 3.29e-37 Metabolic syndrome; CRC cis rs7680126 0.633 rs17389602 chr4:10206926 T/A cg11266682 chr4:10021025 SLC2A9 -0.45 -6.56 -0.34 2.06e-10 Urate levels in lean individuals;Urate levels in overweight individuals;Urate levels in obese individuals; CRC trans rs12478296 1.000 rs55767645 chr2:242999350 G/A cg18288967 chr1:45987694 PRDX1 0.67 6.68 0.35 1.03e-10 Obesity-related traits; CRC cis rs9925964 0.967 rs749767 chr16:31124407 C/T cg03418659 chr16:31128414 MYST1 -0.53 -7.78 -0.39 9.39e-14 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC trans rs561341 1.000 rs55959993 chr17:30254771 C/G cg20587970 chr11:113659929 NA -1.42 -20.11 -0.74 3.29e-59 Hip circumference adjusted for BMI; CRC cis rs1552244 1.000 rs6764168 chr3:10123805 A/G cg18598329 chr3:10140678 FANCD2;C3orf24 -0.87 -11.75 -0.54 7.67e-27 Alzheimer's disease; CRC cis rs10512697 0.655 rs35450818 chr5:3491486 T/C cg19473799 chr5:3511975 NA -0.83 -6.34 -0.33 7.5e-10 Immune response to smallpox vaccine (IL-6); CRC cis rs7666738 0.830 rs3846443 chr4:99032666 G/A cg05340658 chr4:99064831 C4orf37 0.61 9.44 0.46 6.92e-19 Colonoscopy-negative controls vs population controls; CRC cis rs7618915 0.547 rs2268026 chr3:52778347 T/C cg07507251 chr3:52567010 NT5DC2 0.4 5.75 0.3 2.04e-8 Bipolar disorder; CRC cis rs9393692 0.905 rs6940237 chr6:26282322 T/C cg00631329 chr6:26305371 NA -0.69 -13.61 -0.6 8.87e-34 Educational attainment; CRC cis rs7692995 1.000 rs2085683 chr4:18007435 C/G cg08925142 chr4:18023851 LCORL -0.55 -6.06 -0.32 3.73e-9 Height; CRC cis rs12188164 0.543 rs7728027 chr5:459943 T/C cg14122633 chr5:456516 EXOC3 -0.4 -7.17 -0.37 5e-12 Cystic fibrosis severity; CRC cis rs7811142 0.830 rs6945952 chr7:99981775 A/G cg00814883 chr7:100076585 TSC22D4 -0.68 -8.54 -0.43 4.97e-16 Platelet count; CRC cis rs12550646 0.600 rs10089948 chr8:41672453 C/T cg12180191 chr8:41686706 ANK1 0.45 6.89 0.35 2.92e-11 Reticulocyte fraction of red cells;Reticulocyte count; CRC trans rs57590327 0.503 rs13066091 chr3:81589912 T/C cg23387109 chr10:94051229 MARCH5;CPEB3 0.47 6.19 0.32 1.78e-9 Extraversion; CRC cis rs1005277 0.579 rs116912400 chr10:38479207 G/T cg25517755 chr10:38738941 LOC399744 -0.44 -6.44 -0.33 4.31e-10 Extrinsic epigenetic age acceleration; CRC cis rs4423214 0.840 rs1792227 chr11:71177412 A/G cg05163923 chr11:71159392 DHCR7 -0.64 -7.64 -0.39 2.32e-13 Vitamin D levels; CRC cis rs11924390 0.800 rs5030059 chr3:186452455 C/G cg04611788 chr3:186434169 KNG1 -0.58 -8.36 -0.42 1.79e-15 Adiponectin levels; CRC cis rs9322193 0.923 rs4870509 chr6:150023348 C/G cg07701084 chr6:150067640 NUP43 0.56 7.93 0.4 3.57e-14 Lung cancer; CRC cis rs1997103 1.000 rs2331064 chr7:55408610 C/G cg17469321 chr7:55412551 NA 0.72 11.28 0.53 3.48e-25 QRS interval (sulfonylurea treatment interaction); CRC cis rs854765 0.547 rs9896837 chr17:17924868 A/G cg16928487 chr17:17741425 SREBF1 -0.46 -7.89 -0.4 4.56e-14 Total body bone mineral density; CRC cis rs4356975 0.545 rs35297888 chr4:69949573 G/A cg25583503 chr4:69962676 UGT2B7 -0.31 -5.68 -0.3 2.92e-8 Obesity-related traits; CRC cis rs11758351 0.715 rs76130408 chr6:26208962 A/G cg01420254 chr6:26195488 NA 0.79 8.86 0.44 5.19e-17 Gout;Renal underexcretion gout; CRC cis rs875971 1.000 rs778694 chr7:65871558 A/G cg00343986 chr7:65444356 GUSB 0.43 6.3 0.33 9.66e-10 Aortic root size; CRC cis rs427941 0.703 rs201456 chr7:101741059 C/G cg06246474 chr7:101738831 CUX1 0.46 7.24 0.37 3.2e-12 Plasma omega-3 polyunsaturated fatty acid level (eicosapentaenoic acid); CRC trans rs116095464 0.510 rs7714944 chr5:231765 C/T cg00938859 chr5:1591904 SDHAP3 0.7 7.61 0.39 2.85e-13 Breast cancer; CRC cis rs9467711 0.606 rs2073527 chr6:26374978 T/C cg16898833 chr6:26189333 HIST1H4D 0.75 6.55 0.34 2.26e-10 Autism spectrum disorder or schizophrenia; CRC cis rs7613875 0.620 rs7624030 chr3:50071279 A/C cg24308560 chr3:49941425 MST1R 0.43 6.68 0.35 1.04e-10 Body mass index; CRC cis rs6565180 0.632 rs8050812 chr16:30385837 C/T cg01392867 chr16:30410429 ZNF48 -0.4 -5.84 -0.31 1.26e-8 Tonsillectomy; CRC cis rs17401966 0.627 rs35859381 chr1:10466040 G/A cg19773385 chr1:10388646 KIF1B -0.65 -10.44 -0.5 3.23e-22 Hepatocellular carcinoma; CRC cis rs6500395 1.000 rs4785247 chr16:48687732 A/C cg04672837 chr16:48644449 N4BP1 -0.45 -6.63 -0.34 1.38e-10 Response to tocilizumab in rheumatoid arthritis; CRC cis rs9811920 0.638 rs796978 chr3:99564321 A/G cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G -0.45 -6.05 -0.32 4.03e-9 Axial length; CRC cis rs1401999 1.000 rs10937158 chr3:183708439 T/C cg05044414 chr3:183734942 ABCC5 0.48 8.31 0.42 2.56e-15 Anterior chamber depth; CRC cis rs12431939 0.626 rs7160810 chr14:51716467 G/A cg23942311 chr14:51606299 NA 0.54 6.95 0.36 1.93e-11 Cancer; CRC cis rs6540559 0.605 rs3753518 chr1:209977964 G/C cg22029157 chr1:209979665 IRF6 0.73 9.51 0.46 4.11e-19 Cleft lip with or without cleft palate; CRC cis rs853679 0.517 rs9380057 chr6:28104634 G/T cg21251018 chr6:28226885 NKAPL 0.48 6.33 0.33 7.86e-10 Depression; CRC cis rs798554 0.679 rs7784066 chr7:2819727 T/A cg19717773 chr7:2847554 GNA12 -0.42 -6.38 -0.33 5.88e-10 Height; CRC cis rs4919694 0.611 rs7091462 chr10:104948615 C/T cg04362960 chr10:104952993 NT5C2 0.91 9.42 0.46 7.94e-19 Arsenic metabolism; CRC cis rs6963495 0.818 rs73192126 chr7:105175415 T/C cg02135003 chr7:105160482 PUS7 -0.92 -12.46 -0.57 1.94e-29 Bipolar disorder (body mass index interaction); CRC cis rs9916302 0.706 rs7208252 chr17:37584368 A/G cg15445000 chr17:37608096 MED1 0.36 6.27 0.33 1.14e-9 Glomerular filtration rate (creatinine); CRC cis rs7605827 0.930 rs11676198 chr2:15603097 G/A cg19274914 chr2:15703543 NA 0.39 6.01 0.31 4.96e-9 Educational attainment (years of education); CRC cis rs2204008 0.616 rs1607852 chr12:38398125 G/A cg13010199 chr12:38710504 ALG10B 0.45 5.72 0.3 2.42e-8 Bladder cancer; CRC cis rs9303401 0.659 rs2072316 chr17:56604813 G/T cg02118635 chr17:56770003 RAD51C;TEX14 0.81 9.94 0.48 1.52e-20 Cognitive test performance; CRC cis rs9921222 0.521 rs11649255 chr16:357140 A/G cg12437481 chr16:420112 MRPL28 -0.65 -8.86 -0.44 4.97e-17 Bone mineral density (spine);Bone mineral density; CRC cis rs2629540 0.731 rs11245341 chr10:126408777 G/C cg08799069 chr10:126477246 METTL10 0.64 8.12 0.41 9.7e-15 Cocaine dependence; CRC cis rs7809950 1.000 rs4727681 chr7:107096144 T/C cg23024343 chr7:107201750 COG5 -0.61 -8.76 -0.43 1.05e-16 Coronary artery disease; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg27150171 chr12:49961253 MCRS1 0.44 6.12 0.32 2.61e-9 Response to antipsychotic treatment; CRC cis rs4654899 1.000 rs6426659 chr1:21361302 G/A cg02927042 chr1:21476669 EIF4G3 -0.46 -7.37 -0.38 1.43e-12 Superior frontal gyrus grey matter volume; CRC cis rs2710642 0.888 rs13418889 chr2:63079775 T/C cg17519650 chr2:63277830 OTX1 0.43 6.18 0.32 1.94e-9 LDL cholesterol levels;LDL cholesterol; CRC cis rs2991971 0.729 rs10890328 chr1:45905383 G/T cg15605315 chr1:45957053 TESK2 -0.36 -5.81 -0.31 1.48e-8 High light scatter reticulocyte count; CRC cis rs2832191 0.791 rs2832178 chr21:30479858 T/G cg08807101 chr21:30365312 RNF160 -0.64 -10.46 -0.5 2.64e-22 Dental caries; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg14559774 chr8:87355871 WWP1 0.47 6.79 0.35 5.18e-11 Response to antipsychotic treatment; CRC trans rs1814175 0.607 rs11493324 chr11:50011304 T/C cg15704280 chr7:45808275 SEPT13 -0.76 -12.31 -0.56 6.62e-29 Height; CRC cis rs73198271 0.531 rs17154758 chr8:8653343 G/A cg01851573 chr8:8652454 MFHAS1 0.55 6.84 0.35 3.76e-11 Bone ultrasound measurement (broadband ultrasound attenuation); CRC cis rs2108622 1.000 rs2108622 chr19:15990431 C/T cg13772218 chr19:15982569 NA 0.43 6.06 0.32 3.77e-9 Circulating phylloquinone levels;Vitamin E levels;Acenocoumarol maintenance dosage;Response to Vitamin E supplementation;Metabolite levels;Warfarin maintenance dose; CRC cis rs9916302 0.610 rs11078902 chr17:37631883 C/G cg07936489 chr17:37558343 FBXL20 -0.84 -12.93 -0.58 3.44e-31 Glomerular filtration rate (creatinine); CRC cis rs4076764 1.000 rs7540279 chr1:163429970 A/T cg06092702 chr1:163392909 NA -0.57 -8.87 -0.44 4.78e-17 Motion sickness; CRC cis rs728616 0.867 rs41297151 chr10:81807167 A/T cg11900509 chr10:81946545 ANXA11 -0.52 -5.81 -0.3 1.52e-8 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs9322193 0.923 rs10872650 chr6:150082095 A/G cg05861140 chr6:150128134 PCMT1 -0.39 -6.24 -0.33 1.34e-9 Lung cancer; CRC cis rs3996993 0.809 rs11969435 chr6:52664956 C/T cg20803780 chr6:52668592 GSTA1 0.36 6.46 0.34 3.74e-10 Hemoglobin concentration; CRC cis rs77861329 1.000 rs114209632 chr3:52188361 C/T cg08692210 chr3:52188851 WDR51A 0.83 7.17 0.37 4.84e-12 Macrophage inflammatory protein 1b levels; CRC cis rs11997175 0.646 rs4733180 chr8:33700520 C/T ch.8.33884649F chr8:33765107 NA 0.46 6.6 0.34 1.68e-10 Body mass index; CRC cis rs2239547 0.522 rs6792578 chr3:53004604 G/A cg18404041 chr3:52824283 ITIH1 -0.33 -6.3 -0.33 9.67e-10 Schizophrenia; CRC cis rs17767392 0.846 rs4453405 chr14:71757251 A/T cg13720639 chr14:72061746 SIPA1L1 -0.45 -6.06 -0.32 3.75e-9 Mitral valve prolapse; CRC cis rs2243480 1.000 rs778691 chr7:65873092 G/C cg18252515 chr7:66147081 NA -1.3 -15.32 -0.65 2.37e-40 Diabetic kidney disease; CRC cis rs3749237 0.595 rs4955412 chr3:49418168 A/C cg07636037 chr3:49044803 WDR6 0.55 8.1 0.41 1.08e-14 Resting heart rate; CRC cis rs6582630 0.559 rs12318620 chr12:38522340 T/C cg13010199 chr12:38710504 ALG10B -0.43 -6.25 -0.33 1.3e-9 Drug-induced liver injury (flucloxacillin); CRC cis rs7707921 1.000 rs6884232 chr5:81550043 G/A cg17942617 chr5:81327376 ATG10 -0.39 -5.82 -0.31 1.38e-8 Breast cancer; CRC cis rs9322193 0.884 rs7743823 chr6:150170880 A/G cg07701084 chr6:150067640 NUP43 0.48 6.74 0.35 7.18e-11 Lung cancer; CRC trans rs561341 1.000 rs4795668 chr17:30244554 G/A cg20587970 chr11:113659929 NA -1.32 -18.35 -0.71 2.64e-52 Hip circumference adjusted for BMI; CRC cis rs875971 0.660 rs28698552 chr7:66005018 A/G cg11764359 chr7:65958608 NA 0.55 8.6 0.43 3.21e-16 Aortic root size; CRC cis rs10504229 1.000 rs68112919 chr8:58188247 G/A cg01721255 chr8:58191610 C8orf71 0.5 6.21 0.32 1.63e-9 Developmental language disorder (linguistic errors); CRC cis rs10256972 0.616 rs6957733 chr7:1106327 T/G cg18765753 chr7:1198926 ZFAND2A -0.34 -6.08 -0.32 3.3e-9 Longevity;Endometriosis; CRC cis rs11098499 0.866 rs9995136 chr4:120286845 A/G cg24375607 chr4:120327624 NA 0.48 7.48 0.38 6.72e-13 Corneal astigmatism; CRC cis rs9443645 0.901 rs9352686 chr6:79758223 T/G cg11833968 chr6:79620685 NA -0.36 -6.22 -0.32 1.49e-9 Intelligence (multi-trait analysis); CRC cis rs1215050 0.791 rs260890 chr4:98741698 A/G cg05340658 chr4:99064831 C4orf37 0.46 6.74 0.35 7.17e-11 Waist-to-hip ratio adjusted for body mass index; CRC cis rs6557786 0.636 rs17052934 chr8:24840319 A/C cg19677607 chr8:24772270 NEFM -0.38 -6.72 -0.35 8.24e-11 Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 2 peripheral neuropathy); CRC trans rs916888 0.821 rs415430 chr17:44859144 C/T cg23590916 chr17:43697445 MGC57346 -0.57 -6.14 -0.32 2.32e-9 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs367615 0.506 rs2963021 chr5:108800365 C/T cg17395555 chr5:108820864 NA 0.44 8.99 0.44 1.96e-17 Colorectal cancer (SNP x SNP interaction); CRC cis rs1552244 1.000 rs2272123 chr3:10140115 G/A cg10729496 chr3:10149963 C3orf24 0.55 7.29 0.37 2.38e-12 Alzheimer's disease; CRC cis rs6502050 0.835 rs8078087 chr17:80113322 T/G cg13198984 chr17:80129470 CCDC57 0.46 8.16 0.41 6.94e-15 Life satisfaction; CRC cis rs853679 0.517 rs1904841 chr6:28108085 C/T cg15845792 chr6:28175446 NA 1.02 13.74 0.6 2.86e-34 Depression; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg17434043 chr11:2907123 CDKN1C 0.43 6.11 0.32 2.81e-9 Intelligence (multi-trait analysis); CRC cis rs2739330 0.828 rs2154593 chr22:24252085 A/G cg16132339 chr22:24313637 DDTL;DDT 0.64 10.2 0.49 2.01e-21 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs78456975 1.000 rs6720874 chr2:1580504 A/G cg12573674 chr2:1569213 NA -0.67 -7.6 -0.39 3.07e-13 Placebo response in major depressive disorder (% change in symptom score); CRC trans rs10982213 0.830 rs2274163 chr9:117188714 C/T cg19856771 chr13:42780042 DGKH 0.43 6.91 0.36 2.48e-11 Interleukin-6 levels; CRC cis rs62458065 0.640 rs10241303 chr7:32534203 T/G cg20159608 chr7:32802032 NA -0.58 -7.01 -0.36 1.34e-11 Metabolite levels (HVA/MHPG ratio); CRC cis rs798554 0.796 rs2533884 chr7:2836848 T/G cg04166393 chr7:2884313 GNA12 0.51 6.78 0.35 5.63e-11 Height; CRC cis rs6496667 1.000 rs3803538 chr15:90891771 A/G cg04176472 chr15:90893244 GABARAPL3 0.55 8.54 0.43 5.23e-16 Rheumatoid arthritis; CRC cis rs1215050 0.740 rs700739 chr4:99022546 A/G cg05340658 chr4:99064831 C4orf37 -0.49 -7.47 -0.38 7.49e-13 Waist-to-hip ratio adjusted for body mass index; CRC cis rs6500602 0.701 rs4785968 chr16:4535307 T/A cg14951292 chr16:4525986 HMOX2;NMRAL1 0.66 9.55 0.47 3.01e-19 Schizophrenia; CRC cis rs2153535 0.580 rs9406165 chr6:8488837 C/T cg21535247 chr6:8435926 SLC35B3 0.49 7.37 0.38 1.39e-12 Motion sickness; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg08713367 chr6:37225473 TMEM217;TBC1D22B 0.37 6.04 0.32 4.22e-9 Liver disease severity in Alagille syndrome; CRC cis rs11148252 0.553 rs9536236 chr13:53255012 T/A cg12458913 chr13:53173898 NA 0.85 15.84 0.66 2.22e-42 Lewy body disease; CRC trans rs561341 0.941 rs8066558 chr17:30272879 G/T cg20587970 chr11:113659929 NA -1.15 -16.84 -0.68 2.44e-46 Hip circumference adjusted for BMI; CRC cis rs10504229 0.679 rs72649115 chr8:58037631 T/G cg20607798 chr8:58055168 NA 0.49 5.61 0.3 4.23e-8 Developmental language disorder (linguistic errors); CRC cis rs11190604 1.000 rs11190604 chr10:102302457 A/G cg07080220 chr10:102295463 HIF1AN 0.5 6.0 0.31 5.11e-9 Palmitoleic acid (16:1n-7) levels; CRC cis rs4478858 0.684 rs7521463 chr1:31761936 T/A cg00250761 chr1:31883323 NA -0.43 -8.37 -0.42 1.68e-15 Alcohol dependence; CRC cis rs1223397 0.651 rs2919686 chr6:13312641 A/G cg20827128 chr6:13274284 PHACTR1 0.38 5.81 0.3 1.5e-8 Blood pressure; CRC cis rs3731896 0.700 rs2271593 chr2:220168607 C/T cg00436969 chr2:220197716 RESP18 -0.46 -5.95 -0.31 6.7e-9 Educational attainment; CRC cis rs2281845 0.929 rs6704363 chr1:201096383 A/G cg08885800 chr1:201084119 NA 0.48 8.69 0.43 1.75e-16 Permanent tooth development; CRC cis rs611744 0.550 rs1448154 chr8:109281053 T/C cg18478394 chr8:109455254 TTC35 0.38 5.89 0.31 9.79e-9 Dupuytren's disease; CRC trans rs61931739 0.817 rs7963318 chr12:34244929 C/G cg26384229 chr12:38710491 ALG10B -0.43 -6.02 -0.31 4.68e-9 Morning vs. evening chronotype; CRC cis rs7901135 0.962 rs7087585 chr10:60569229 G/A cg23799393 chr10:60588674 BICC1 0.36 5.61 0.3 4.25e-8 Morning vs. evening chronotype; CRC cis rs7072216 0.763 rs7911036 chr10:100167015 A/T cg26618903 chr10:100175079 PYROXD2 -0.55 -9.26 -0.45 2.73e-18 Metabolite levels; CRC trans rs8073060 0.544 rs9912939 chr17:34005264 T/G cg19694781 chr19:47549865 TMEM160 -1.06 -14.24 -0.62 3.54e-36 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; CRC cis rs6735179 0.643 rs10200618 chr2:1746140 A/C cg19300414 chr2:1746591 PXDN 0.43 7.25 0.37 3.04e-12 Response to antipsychotic treatment; CRC trans rs2243480 1.000 rs778691 chr7:65873092 G/C cg10756647 chr7:56101905 PSPH 0.78 8.01 0.4 1.97e-14 Diabetic kidney disease; CRC cis rs4757319 0.532 rs10766251 chr11:15443681 A/G cg03245590 chr11:15329459 NA -0.39 -6.7 -0.35 9.09e-11 Breast cancer; CRC cis rs9467711 0.659 rs35277236 chr6:26562269 G/T cg08501292 chr6:25962987 TRIM38 0.88 6.11 0.32 2.84e-9 Autism spectrum disorder or schizophrenia; CRC cis rs4563143 0.514 rs55727361 chr19:29300415 A/T cg12667521 chr19:29218732 NA 0.52 7.16 0.37 5.18e-12 Methadone dose in opioid dependence; CRC cis rs3772130 0.885 rs9816844 chr3:121496324 C/T cg20356878 chr3:121714668 ILDR1 0.51 8.03 0.4 1.74e-14 Cognitive performance; CRC cis rs10504229 0.954 rs903717 chr8:58167856 A/G cg24829409 chr8:58192753 C8orf71 -0.51 -9.42 -0.46 8.29e-19 Developmental language disorder (linguistic errors); CRC cis rs9902453 0.967 rs28792710 chr17:28450015 T/C cg26525008 chr17:28256777 EFCAB5;SSH2 0.61 9.7 0.47 1.03e-19 Coffee consumption (cups per day); CRC cis rs4665809 1.000 rs6704930 chr2:26325705 G/A cg22920501 chr2:26401640 FAM59B -0.52 -7.15 -0.37 5.68e-12 Gut microbiome composition (summer); CRC cis rs2456568 0.802 rs11020585 chr11:93638493 A/C cg26875233 chr11:93583750 C11orf90 0.31 6.09 0.32 3.11e-9 Response to serotonin reuptake inhibitors in major depressive disorder; CRC cis rs2806561 0.695 rs66592286 chr1:23333649 G/C cg12483005 chr1:23474871 LUZP1 0.44 6.33 0.33 7.98e-10 Height; CRC cis rs7811142 1.000 rs7787620 chr7:100089234 A/G cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.17 17.06 0.69 3.29e-47 Platelet count; CRC trans rs6703335 0.870 rs10803142 chr1:243598234 A/G cg08092331 chr12:121019201 POP5 0.44 5.99 0.31 5.57e-9 Schizophrenia;Schizophrenia, schizoaffective disorder or bipolar disorder; CRC cis rs524281 0.817 rs10896092 chr11:65958046 A/C cg16950941 chr11:66035639 RAB1B -0.57 -7.14 -0.37 5.84e-12 Electroencephalogram traits; CRC cis rs7107770 0.739 rs12793744 chr11:125079871 G/T cg27629782 chr11:125073726 PKNOX2 0.54 7.87 0.4 5.23e-14 Photic sneeze reflex; CRC cis rs7618915 0.571 rs12632381 chr3:52607685 G/A cg18404041 chr3:52824283 ITIH1 -0.44 -9.05 -0.45 1.29e-17 Bipolar disorder; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg07660663 chr8:117886887 RAD21 0.47 6.62 0.34 1.44e-10 Response to antipsychotic treatment; CRC cis rs1799949 0.894 rs8176160 chr17:41241503 T/C cg25072359 chr17:41440525 NA 0.47 7.02 0.36 1.27e-11 Menopause (age at onset); CRC cis rs4604732 0.631 rs74154673 chr1:247625629 G/A cg02104434 chr1:247694406 LOC148824;OR2C3 0.6 8.82 0.44 6.67e-17 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CRC cis rs459193 1.000 rs256904 chr5:55810305 A/T cg18302225 chr5:55776401 NA 0.43 5.73 0.3 2.28e-8 Coronary artery disease;Type 2 diabetes;Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);Waist-to-hip ratio adjusted for BMI in non-smokers;Waist-to-hip ratio adjusted for BMI (smoking interaction);Waist-to-hip ratio adjusted for body mass index;Waist-hip ratio;Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction); CRC cis rs3806843 0.900 rs2337984 chr5:140136811 G/A cg16607685 chr5:140181889 PCDHA2;PCDHA1;PCDHA3 0.28 6.41 0.33 5e-10 Depressive symptoms (multi-trait analysis); CRC cis rs6460942 1.000 rs17191008 chr7:12417690 T/G cg06484146 chr7:12443880 VWDE -0.74 -7.28 -0.37 2.47e-12 Coronary artery disease; CRC trans rs17111230 0.675 rs1349568 chr14:41315945 A/C cg26721700 chr19:35645598 FXYD5 0.41 6.05 0.32 3.96e-9 Congenital heart disease (inherited effect); CRC cis rs7772486 0.875 rs12194437 chr6:146411440 A/G cg23711669 chr6:146136114 FBXO30 0.66 11.56 0.54 3.54e-26 Lobe attachment (rater-scored or self-reported); CRC cis rs477895 0.713 rs35095324 chr11:63948412 G/A cg19465662 chr11:63993652 NUDT22;TRPT1 0.72 8.84 0.44 5.76e-17 Mean platelet volume; CRC cis rs7727544 0.735 rs272884 chr5:131668654 G/C cg11843238 chr5:131593191 PDLIM4 0.3 5.64 0.3 3.74e-8 Blood metabolite levels; CRC cis rs1697139 0.583 rs1428474 chr5:66544015 C/A cg11553311 chr5:66541588 NA 0.58 9.83 0.48 3.71e-20 Breast cancer; CRC cis rs34330 0.562 rs11055025 chr12:12866619 A/T cg04607235 chr12:12878440 APOLD1 -0.69 -7.26 -0.37 2.86e-12 Systemic lupus erythematosus; CRC cis rs737337 0.623 rs4804154 chr19:11334179 C/T cg00586551 chr19:11347513 LOC55908;DOCK6 0.79 8.85 0.44 5.52e-17 HDL cholesterol;HDL cholesterol levels; CRC cis rs7918232 0.941 rs4749228 chr10:27433618 C/T cg14442939 chr10:27389572 ANKRD26 -0.81 -9.05 -0.45 1.25e-17 Breast cancer; CRC cis rs1707322 0.721 rs10890333 chr1:46100322 T/C cg06784218 chr1:46089804 CCDC17 0.66 12.5 0.57 1.36e-29 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs10504229 0.639 rs2291764 chr8:58142943 A/C cg20607798 chr8:58055168 NA 0.53 6.04 0.32 4.19e-9 Developmental language disorder (linguistic errors); CRC cis rs2806561 0.704 rs6680974 chr1:23376233 A/G cg12483005 chr1:23474871 LUZP1 0.46 6.54 0.34 2.35e-10 Height; CRC cis rs9303401 0.632 rs7222087 chr17:57221619 A/T cg10487724 chr17:56770010 TEX14;RAD51C 0.44 6.61 0.34 1.57e-10 Cognitive test performance; CRC trans rs7937682 0.960 rs480293 chr11:111469132 A/C cg18187862 chr3:45730750 SACM1L 0.43 6.14 0.32 2.38e-9 Primary sclerosing cholangitis; CRC cis rs3806843 0.931 rs13168670 chr5:140146899 T/C cg16607685 chr5:140181889 PCDHA2;PCDHA1;PCDHA3 -0.27 -6.22 -0.32 1.51e-9 Depressive symptoms (multi-trait analysis); CRC cis rs7605827 0.930 rs4668451 chr2:15675285 C/T cg19274914 chr2:15703543 NA 0.39 5.87 0.31 1.07e-8 Educational attainment (years of education); CRC cis rs6502050 0.764 rs7215277 chr17:80159283 C/A cg19223190 chr17:80058835 NA 0.41 6.7 0.35 8.79e-11 Life satisfaction; CRC cis rs2180341 1.000 rs4895822 chr6:127642703 T/C cg24812749 chr6:127587940 RNF146 0.95 13.63 0.6 7.53e-34 Breast cancer; CRC cis rs3741151 0.773 rs73544729 chr11:73183418 G/T cg17517138 chr11:73019481 ARHGEF17 1.04 8.44 0.42 1.01e-15 GIP levels in response to oral glucose tolerance test (120 minutes); CRC cis rs889312 0.500 rs1867731 chr5:56132115 C/G cg18230493 chr5:56204884 C5orf35 -0.39 -5.83 -0.31 1.33e-8 Breast cancer;Breast cancer (early onset); CRC cis rs6598955 0.724 rs884533 chr1:26585657 G/T cg04990556 chr1:26633338 UBXN11 -0.79 -13.39 -0.59 6.36e-33 Obesity-related traits; CRC cis rs76878669 0.561 rs4930179 chr11:66157432 C/T cg18002602 chr11:66138449 SLC29A2 0.27 5.85 0.31 1.22e-8 Educational attainment (years of education); CRC cis rs7591163 0.883 rs11891398 chr2:228723357 C/T cg00063174 chr2:228736253 WDR69 -0.47 -6.32 -0.33 8.42e-10 Blood pressure; CRC cis rs1448094 0.512 rs61930862 chr12:86246567 A/G cg02569458 chr12:86230093 RASSF9 0.43 7.41 0.38 1.06e-12 Major depressive disorder; CRC cis rs6988636 0.892 rs58116120 chr8:124191776 T/G cg27053337 chr8:124217698 FAM83A 0.35 5.77 0.3 1.87e-8 Urinary uromodulin levels; CRC cis rs1728785 1.000 rs698712 chr16:68561879 G/A cg02972257 chr16:68554789 NA -0.59 -7.34 -0.38 1.71e-12 Ulcerative colitis; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg00253204 chr17:16118700 NCOR1 0.43 6.07 0.32 3.5e-9 Response to antipsychotic treatment; CRC cis rs1862618 0.853 rs866222 chr5:56184444 T/C cg22800045 chr5:56110881 MAP3K1 0.62 6.64 0.34 1.29e-10 Initial pursuit acceleration; CRC cis rs4319547 0.915 rs7966094 chr12:123115771 A/G cg23029597 chr12:123009494 RSRC2 -0.66 -8.15 -0.41 7.67e-15 Body mass index; CRC cis rs5750830 0.649 rs5750813 chr22:39795228 G/C cg25459000 chr22:39777742 SYNGR1 -0.32 -5.61 -0.3 4.28e-8 Intelligence (multi-trait analysis); CRC cis rs35306767 0.903 rs61830933 chr10:934195 G/A cg26597838 chr10:835615 NA 1.25 14.7 0.63 6.01e-38 Eosinophil percentage of granulocytes; CRC cis rs172166 0.516 rs1225618 chr6:28129713 A/C cg12273811 chr6:28175739 NA 0.46 7.02 0.36 1.31e-11 Cardiac Troponin-T levels; CRC cis rs875971 0.862 rs3926380 chr7:66080645 G/T cg11764359 chr7:65958608 NA -0.59 -8.76 -0.43 1.09e-16 Aortic root size; CRC cis rs887829 0.570 rs7608175 chr2:234599089 C/G cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 0.45 6.96 0.36 1.83e-11 Metabolic traits;Bilirubin levels;Cholelithiasis-related traits in sickle cell anemia;Metabolite levels;Total bilirubin levels in HIV-1 infection;Serum metabolite levels;Blood metabolite levels; CRC cis rs2832191 0.791 rs2832182 chr21:30481612 G/A cg24692254 chr21:30365293 RNF160 -0.7 -12.39 -0.56 3.29e-29 Dental caries; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg15068520 chr10:79789178 POLR3A 0.42 6.1 0.32 2.95e-9 Intelligence (multi-trait analysis); CRC cis rs6662572 0.703 rs4364819 chr1:46358510 G/A cg08644498 chr1:46502608 NA -0.44 -6.92 -0.36 2.32e-11 Blood protein levels; CRC cis rs7659604 0.728 rs3924987 chr4:122689784 G/T cg06713675 chr4:122721982 EXOSC9 -0.53 -8.45 -0.42 9.73e-16 Type 2 diabetes; CRC cis rs7224685 0.501 rs781850 chr17:3957124 C/T cg11204139 chr17:3907470 NA -0.76 -13.98 -0.61 3.52e-35 Type 2 diabetes; CRC cis rs60843830 1.000 rs57542652 chr2:228088 G/A cg00108164 chr2:264199 ACP1;SH3YL1 0.62 9.52 0.46 3.93e-19 Spherical equivalent (joint analysis main effects and education interaction); CRC cis rs17641971 0.684 rs4873310 chr8:49990006 A/T cg00325661 chr8:49890786 NA 0.37 6.22 0.32 1.51e-9 Blood metabolite levels; CRC cis rs1862618 1.000 rs1862618 chr5:56096315 C/G cg03609598 chr5:56110824 MAP3K1 -0.74 -9.13 -0.45 6.98e-18 Initial pursuit acceleration; CRC trans rs8002861 0.905 rs12430629 chr13:44415919 T/A cg12856521 chr11:46389249 DGKZ -0.43 -6.87 -0.35 3.13e-11 Leprosy; CRC cis rs5769765 0.773 rs9616206 chr22:50310847 G/T cg02269571 chr22:50332266 NA -0.6 -7.73 -0.39 1.33e-13 Schizophrenia; CRC cis rs67340775 0.541 rs200966 chr6:27862152 T/C cg15845792 chr6:28175446 NA 0.84 8.84 0.44 5.86e-17 Lung cancer in ever smokers; CRC cis rs7589728 0.563 rs75606549 chr2:88466069 T/C cg04511125 chr2:88470314 THNSL2 0.81 8.56 0.43 4.31e-16 Plasma clusterin levels; CRC trans rs2303319 0.504 rs56384808 chr2:162347755 G/T cg04145477 chr6:107077629 RTN4IP1;QRSL1 -0.77 -6.04 -0.32 4.18e-9 Cognitive function; CRC cis rs7917772 0.512 rs11594073 chr10:104308193 T/C cg11453585 chr10:104263688 ACTR1A;SUFU -0.83 -15.08 -0.64 1.96e-39 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC cis rs780096 0.565 rs813592 chr2:27721971 T/C cg12000995 chr2:27665139 KRTCAP3 -0.3 -6.4 -0.33 5.49e-10 Total body bone mineral density; CRC cis rs477895 0.838 rs35090903 chr11:64000598 C/T cg18225595 chr11:63971243 STIP1 0.61 7.85 0.4 5.9e-14 Mean platelet volume; CRC cis rs6604026 0.883 rs77741804 chr1:93324038 C/T cg22128645 chr1:93425802 FAM69A -0.4 -5.91 -0.31 8.78e-9 Multiple sclerosis; CRC cis rs35110281 0.682 rs162379 chr21:44925334 A/G cg04455712 chr21:45112962 RRP1B -0.38 -6.96 -0.36 1.8e-11 Mean corpuscular volume; CRC trans rs2303319 0.504 rs56965753 chr2:162597251 A/G cg11326919 chr17:43324904 LOC100133991 -0.64 -5.97 -0.31 5.99e-9 Cognitive function; CRC cis rs1552244 0.554 rs4488814 chr3:10002400 C/T cg02579736 chr3:10068473 FANCD2;CIDECP -0.64 -9.09 -0.45 9.33e-18 Alzheimer's disease; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg02562419 chr6:159049626 TMEM181 0.4 6.0 0.31 5.24e-9 Myopia (pathological); CRC cis rs9393692 0.875 rs6939589 chr6:26289203 C/T cg00631329 chr6:26305371 NA 0.68 13.43 0.6 4.24e-33 Educational attainment; CRC cis rs524023 0.914 rs2360872 chr11:64353405 T/C cg06522879 chr11:64358276 SLC22A12 -0.58 -9.08 -0.45 1.05e-17 Urate levels in obese individuals; CRC cis rs4332037 0.707 rs62435132 chr7:1891315 C/T cg23422044 chr7:1970798 MAD1L1 -0.49 -6.36 -0.33 6.81e-10 Bipolar disorder; CRC cis rs1215050 0.791 rs2865942 chr4:98737709 G/C cg05340658 chr4:99064831 C4orf37 0.43 6.44 0.33 4.34e-10 Waist-to-hip ratio adjusted for body mass index; CRC cis rs6952808 0.564 rs55865401 chr7:2145720 G/C cg21782813 chr7:2030301 MAD1L1 0.5 8.84 0.44 5.92e-17 Bipolar disorder and schizophrenia; CRC cis rs7487075 0.820 rs1586905 chr12:46707618 T/A cg22049899 chr12:47219821 SLC38A4 0.33 6.24 0.33 1.36e-9 Itch intensity from mosquito bite; CRC cis rs7843479 0.601 rs10866837 chr8:21861663 G/C cg16476235 chr8:21771668 DOK2 0.41 7.01 0.36 1.38e-11 Mean corpuscular volume; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg01145398 chr10:135075451 NA 0.39 6.43 0.33 4.54e-10 Liver disease severity in Alagille syndrome; CRC cis rs4474465 0.703 rs10899547 chr11:78254720 C/T cg02023728 chr11:77925099 USP35 -0.38 -6.39 -0.33 5.54e-10 Alzheimer's disease (survival time); CRC cis rs7833986 0.501 rs17814658 chr8:56989130 T/C cg23139584 chr8:56987506 RPS20;SNORD54 0.91 12.38 0.56 3.75e-29 Height; CRC cis rs10256972 0.591 rs6950319 chr7:1161324 A/G cg26608667 chr7:1196370 ZFAND2A 0.36 5.62 0.3 3.99e-8 Longevity;Endometriosis; CRC cis rs3823572 0.586 rs2971969 chr7:133656264 G/T cg03336402 chr7:133662267 EXOC4 -0.66 -10.27 -0.49 1.24e-21 Intelligence (multi-trait analysis); CRC cis rs875971 0.965 rs10267430 chr7:65743023 G/T cg00343986 chr7:65444356 GUSB -0.44 -6.42 -0.33 4.74e-10 Aortic root size; CRC cis rs2239547 0.563 rs4302374 chr3:52905802 T/C cg18404041 chr3:52824283 ITIH1 -0.38 -7.03 -0.36 1.19e-11 Schizophrenia; CRC cis rs2281845 0.965 rs3738262 chr1:201083343 A/G cg22815214 chr1:201083145 CACNA1S 0.6 9.84 0.48 3.48e-20 Permanent tooth development; CRC cis rs2404602 0.692 rs12913810 chr15:77166675 T/C cg03037974 chr15:76606532 NA 0.68 11.55 0.54 4.06e-26 Blood metabolite levels; CRC cis rs896854 0.654 rs1453377 chr8:95969947 C/T cg09323728 chr8:95962352 TP53INP1 -0.41 -6.94 -0.36 2.09e-11 Type 2 diabetes; CRC cis rs25422 0.938 rs7356858 chr6:118765814 G/C cg18833306 chr6:118973337 C6orf204 0.44 5.74 0.3 2.12e-8 Renal cell carcinoma; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg15807180 chr15:74907231 CLK3 0.46 6.46 0.34 3.75e-10 Anxiety disorder; CRC cis rs57994353 0.667 rs34985258 chr9:139327154 C/T cg14119001 chr9:139324193 INPP5E -0.47 -6.72 -0.35 7.96e-11 Eosinophil counts;Cutaneous squamous cell carcinoma; CRC cis rs6964587 0.692 rs2374550 chr7:91820987 A/G cg17063962 chr7:91808500 NA 0.64 10.41 0.5 3.86e-22 Breast cancer; CRC cis rs9649213 0.593 rs62478233 chr7:98023092 T/C cg24562669 chr7:97807699 LMTK2 0.43 7.12 0.37 6.76e-12 Prostate cancer (SNP x SNP interaction); CRC cis rs9859260 0.744 rs492288 chr3:195784210 C/T cg12923728 chr3:195709715 SDHAP1 0.48 6.54 0.34 2.35e-10 Mean corpuscular volume; CRC cis rs11650494 0.710 rs11651666 chr17:47474571 C/T cg08112188 chr17:47440006 ZNF652 0.8 6.57 0.34 1.97e-10 Prostate cancer; CRC cis rs2380220 0.576 rs7751219 chr6:96018915 G/A cg04719120 chr6:96025338 MANEA 0.74 9.35 0.46 1.35e-18 Behavioural disinhibition (generation interaction); CRC cis rs1707322 0.964 rs785496 chr1:46588006 T/C cg03146154 chr1:46216737 IPP -0.59 -8.06 -0.41 1.44e-14 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs780096 0.526 rs1406295 chr2:27689700 A/G cg27432699 chr2:27873401 GPN1 -0.52 -7.96 -0.4 2.91e-14 Total body bone mineral density; CRC cis rs2304069 0.545 rs9686746 chr5:149399968 G/A cg22760475 chr5:149380129 HMGXB3;TIGD6 0.46 6.68 0.35 1.02e-10 HIV-1 control; CRC cis rs9611565 0.503 rs5996062 chr22:42167464 C/G cg03806693 chr22:41940476 POLR3H 1.1 13.52 0.6 2e-33 Vitiligo; CRC cis rs6748734 0.625 rs7355583 chr2:241821707 T/C cg16358738 chr2:241808595 AGXT -0.4 -6.98 -0.36 1.59e-11 Urinary metabolites; CRC cis rs7666738 0.830 rs7667796 chr4:99071415 G/T cg17366294 chr4:99064904 C4orf37 -0.44 -7.41 -0.38 1.08e-12 Colonoscopy-negative controls vs population controls; CRC cis rs10426930 0.639 rs1136405 chr19:5062814 T/C cg18473234 chr19:5097819 KDM4B -0.48 -6.08 -0.32 3.36e-9 Monocyte percentage of white cells; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg20099147 chr19:56652066 ZNF444 0.51 6.56 0.34 2.08e-10 Thyroid stimulating hormone; CRC trans rs12458462 0.892 rs3786228 chr18:77464170 C/T cg09220050 chr20:48770642 TMEM189;TMEM189-UBE2V1 0.44 6.25 0.33 1.29e-9 Monocyte count; CRC cis rs8060686 0.858 rs2008173 chr16:67856240 A/G cg19582491 chr16:67682965 RLTPR -0.41 -5.9 -0.31 8.82e-9 HDL cholesterol;Metabolic syndrome; CRC cis rs1451375 0.669 rs10274172 chr7:50637575 G/A cg14593290 chr7:50529359 DDC -0.52 -7.21 -0.37 3.96e-12 Malaria; CRC cis rs1950626 0.716 rs34158896 chr14:101447373 T/C cg02351406 chr14:101447389 SNORD114-20;SNORD114-21 0.97 15.89 0.66 1.42e-42 Pelvic organ prolapse (moderate/severe); CRC cis rs2120019 0.567 rs8037152 chr15:75156996 A/T cg09165964 chr15:75287851 SCAMP5 -0.62 -7.63 -0.39 2.62e-13 Blood trace element (Zn levels); CRC cis rs12230513 0.793 rs1896044 chr12:55953670 T/A cg19537932 chr12:55886519 OR6C68 -0.42 -5.65 -0.3 3.56e-8 Contrast sensitivity; CRC cis rs7666738 0.753 rs35194639 chr4:99053819 G/C cg05340658 chr4:99064831 C4orf37 0.6 9.37 0.46 1.17e-18 Colonoscopy-negative controls vs population controls; CRC cis rs728616 0.867 rs4387301 chr10:81736399 C/T cg11900509 chr10:81946545 ANXA11 -0.68 -6.82 -0.35 4.39e-11 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs9858542 0.903 rs11921590 chr3:49644193 T/C cg07274523 chr3:49395745 GPX1 0.45 5.75 0.3 2.06e-8 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs1552244 0.882 rs3755782 chr3:10029305 T/C cg18598329 chr3:10140678 FANCD2;C3orf24 -0.81 -10.69 -0.51 4.18e-23 Alzheimer's disease; CRC cis rs2075371 0.829 rs727202 chr7:133947942 A/G cg20476274 chr7:133979776 SLC35B4 0.72 11.95 0.55 1.38e-27 Mean platelet volume; CRC trans rs877282 0.898 rs71489279 chr10:760510 T/C cg22713356 chr15:30763199 NA 1.25 15.02 0.64 3.34e-39 Uric acid levels; CRC trans rs1814175 0.562 rs1794130 chr11:49903764 T/A cg15704280 chr7:45808275 SEPT13 -0.95 -16.82 -0.68 3.11e-46 Height; CRC cis rs10479542 0.896 rs4701130 chr5:178982416 C/T cg09060608 chr5:178986726 RUFY1 -0.54 -9.47 -0.46 5.49e-19 Lung cancer; CRC cis rs12541635 1.000 rs1896919 chr8:107090357 C/G cg10147462 chr8:107024639 NA -0.36 -6.12 -0.32 2.68e-9 Age of smoking initiation; CRC cis rs7666738 0.830 rs28615340 chr4:98896922 T/C cg05340658 chr4:99064831 C4orf37 0.57 8.6 0.43 3.31e-16 Colonoscopy-negative controls vs population controls; CRC cis rs6502050 0.835 rs4789666 chr17:80162276 C/T cg02741985 chr17:80059408 CCDC57 0.44 7.36 0.38 1.5e-12 Life satisfaction; CRC cis rs875971 0.660 rs10950044 chr7:66042976 A/G cg18876405 chr7:65276391 NA -0.61 -11.09 -0.52 1.75e-24 Aortic root size; CRC trans rs4308415 0.726 rs12509233 chr4:67811618 C/T cg19648955 chr2:177134095 MTX2 -0.42 -6.36 -0.33 6.7e-10 Educational attainment (years of education); CRC cis rs10992471 1.000 rs10992471 chr9:95559505 A/G cg14631576 chr9:95140430 CENPP 0.31 5.68 0.3 3.01e-8 Visceral adipose tissue/subcutaneous adipose tissue ratio; CRC trans rs6951245 1.000 rs75488469 chr7:1102122 A/G cg13565492 chr6:43139072 SRF -0.7 -7.31 -0.37 2.06e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs1707322 0.663 rs3935296 chr1:46180470 T/C cg03146154 chr1:46216737 IPP -0.68 -9.94 -0.48 1.59e-20 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs11622475 1.000 rs11625697 chr14:104464800 C/T cg12183467 chr14:104352244 NA -0.47 -6.57 -0.34 2e-10 Bipolar disorder; CRC cis rs2857891 1.000 rs2638092 chr11:6961746 G/A cg12728517 chr11:6947552 ZNF215 0.57 6.16 0.32 2.17e-9 Response to cytadine analogues (cytosine arabinoside); CRC cis rs2304069 0.954 rs4705409 chr5:149414899 A/G cg22760475 chr5:149380129 HMGXB3;TIGD6 0.87 10.25 0.49 1.43e-21 HIV-1 control; CRC cis rs875971 1.000 rs778710 chr7:65854834 T/C cg12463550 chr7:65579703 CRCP 0.48 6.96 0.36 1.89e-11 Aortic root size; CRC cis rs7113874 0.569 rs10769915 chr11:8597449 C/G cg20771178 chr11:8615675 STK33 -0.35 -5.75 -0.3 2.02e-8 Body mass index in physically active individuals;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs798554 0.797 rs798494 chr7:2798294 C/A cg17321639 chr7:2759063 NA -0.52 -7.05 -0.36 1.08e-11 Height; CRC cis rs896854 0.684 rs10098778 chr8:95992020 C/T cg09323728 chr8:95962352 TP53INP1 -0.44 -7.24 -0.37 3.28e-12 Type 2 diabetes; CRC cis rs11148252 0.904 rs7990581 chr13:53019433 A/G cg00495681 chr13:53174319 NA 0.66 10.44 0.5 3.09e-22 Lewy body disease; CRC cis rs694739 0.796 rs479777 chr11:64107477 A/G cg23796481 chr11:64053134 BAD;GPR137 0.53 7.99 0.4 2.23e-14 Alopecia areata;Crohn's disease;Psoriasis vulgaris; CRC cis rs2074585 0.517 rs11637971 chr15:91079863 A/C cg04176472 chr15:90893244 GABARAPL3 -0.38 -5.92 -0.31 8.09e-9 Basophil percentage of granulocytes;White blood cell count (basophil);Basophil percentage of white cells; CRC cis rs2108225 0.934 rs2283044 chr7:107440553 A/G cg18560240 chr7:107437656 SLC26A3 0.54 8.31 0.42 2.47e-15 Ulcerative colitis; CRC cis rs881375 0.967 rs1930781 chr9:123687834 G/A cg09419670 chr9:123605666 PSMD5;LOC253039 0.57 8.47 0.42 8.03e-16 Rheumatoid arthritis; CRC cis rs4891159 0.790 rs10514217 chr18:74144939 A/G cg24786174 chr18:74118243 ZNF516 -0.84 -12.85 -0.58 6.69e-31 Longevity; CRC cis rs6546550 0.901 rs3732266 chr2:70057448 T/G cg02498382 chr2:70120550 SNRNP27 -0.48 -7.83 -0.4 6.93e-14 Prevalent atrial fibrillation; CRC cis rs9837602 1.000 rs28714363 chr3:99752068 G/T cg07805332 chr3:99536008 MIR548G;C3orf26 -0.48 -6.34 -0.33 7.79e-10 Breast cancer; CRC cis rs4713118 0.513 rs156734 chr6:28007357 A/C cg12172441 chr6:28176163 NA 0.52 7.29 0.37 2.27e-12 Parkinson's disease; CRC cis rs28386778 0.799 rs2727322 chr17:61921706 G/A cg06873352 chr17:61820015 STRADA 0.76 14.24 0.62 3.62e-36 Prudent dietary pattern; CRC cis rs11628318 0.660 rs35258120 chr14:103058769 G/A cg23461800 chr14:103021989 NA -0.61 -7.24 -0.37 3.28e-12 Platelet count; CRC cis rs6496667 1.000 rs6496667 chr15:90893668 C/A cg04176472 chr15:90893244 GABARAPL3 0.52 7.94 0.4 3.26e-14 Rheumatoid arthritis; CRC cis rs9372498 0.505 rs4416700 chr6:118975461 G/C cg01339444 chr6:118972232 C6orf204 0.58 6.24 0.33 1.35e-9 Diastolic blood pressure; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg17994379 chr17:43025264 KIF18B 0.46 6.21 0.32 1.64e-9 Thyroid stimulating hormone; CRC cis rs2710642 0.888 rs2539985 chr2:63134507 T/A cg17519650 chr2:63277830 OTX1 0.46 6.43 0.33 4.54e-10 LDL cholesterol levels;LDL cholesterol; CRC cis rs11105298 0.891 rs11105313 chr12:89923376 A/T cg00757033 chr12:89920650 WDR51B -0.37 -6.28 -0.33 1.07e-9 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; CRC cis rs9611565 0.649 rs79005 chr22:41835544 G/A cg03806693 chr22:41940476 POLR3H 0.96 12.91 0.58 3.84e-31 Vitiligo; CRC cis rs853679 0.517 rs16893666 chr6:28054707 C/T cg15845792 chr6:28175446 NA -0.99 -13.35 -0.59 9.01e-33 Depression; CRC cis rs6499255 1.000 rs7189424 chr16:69782746 G/A cg15192750 chr16:69999425 NA 0.55 7.17 0.37 4.99e-12 IgE levels; CRC cis rs11722228 1.000 rs11722228 chr4:9915741 C/T cg11266682 chr4:10021025 SLC2A9 0.39 6.82 0.35 4.24e-11 Gout;Urate levels;Serum uric acid levels; CRC cis rs2346177 0.542 rs13024414 chr2:46687062 G/A cg02822958 chr2:46747628 ATP6V1E2 0.41 5.82 0.31 1.41e-8 HDL cholesterol; CRC cis rs365302 1.000 rs433171 chr6:159645378 C/T cg14500486 chr6:159655392 FNDC1 0.43 6.59 0.34 1.76e-10 Coronary heart disease; CRC cis rs4713118 0.616 rs9348789 chr6:28025486 C/T cg03623178 chr6:28175578 NA 0.92 13.02 0.58 1.52e-31 Parkinson's disease; CRC cis rs10876993 0.928 rs10082911 chr12:58104104 C/A cg15848620 chr12:58087721 OS9 -0.62 -8.68 -0.43 1.92e-16 Celiac disease or Rheumatoid arthritis; CRC cis rs1552244 1.000 rs7622966 chr3:10139833 C/T cg16606324 chr3:10149918 C3orf24 0.69 9.75 0.47 6.97e-20 Alzheimer's disease; CRC cis rs1348850 0.914 rs10497503 chr2:178371739 G/T cg22681709 chr2:178499509 PDE11A -0.37 -6.72 -0.35 7.97e-11 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs1153858 1.000 rs7179743 chr15:45638331 G/C cg14582100 chr15:45693742 SPATA5L1 0.28 5.87 0.31 1.07e-8 Homoarginine levels; CRC cis rs765787 0.530 rs2899381 chr15:45529630 C/T cg24006582 chr15:45444508 DUOX1 -0.58 -8.82 -0.44 6.97e-17 Uric acid levels; CRC cis rs2243480 1.000 rs958550 chr7:65635679 C/T cg12463550 chr7:65579703 CRCP -0.67 -6.32 -0.33 8.51e-10 Diabetic kidney disease; CRC cis rs7552404 0.690 rs7549863 chr1:76327923 T/C cg03433033 chr1:76189801 ACADM -0.64 -8.52 -0.43 5.91e-16 Blood metabolite levels;Acylcarnitine levels; CRC cis rs67478160 0.643 rs2887282 chr14:104280734 A/G cg01849466 chr14:104193079 ZFYVE21 -0.47 -7.99 -0.4 2.23e-14 Schizophrenia; CRC cis rs6540556 0.682 rs932335 chr1:209905734 G/C cg05527609 chr1:210001259 C1orf107 -0.56 -6.21 -0.32 1.56e-9 Red blood cell count; CRC cis rs2742540 0.503 rs982273 chr11:8906862 T/G cg00186954 chr11:8933980 ST5;C11orf17 -0.65 -11.77 -0.54 6.3e-27 Hematocrit; CRC cis rs2302190 0.882 rs7221205 chr17:56485799 G/A cg12560992 chr17:57184187 TRIM37 0.47 5.94 0.31 7.16e-9 Vitamin D levels; CRC trans rs2014572 0.875 rs10405008 chr19:57753643 C/G cg02674126 chr19:40336878 FBL -0.41 -6.56 -0.34 2.06e-10 Hyperactive-impulsive symptoms; CRC cis rs9486715 0.867 rs2499775 chr6:97007340 C/T cg06623918 chr6:96969491 KIAA0776 -1.03 -20.89 -0.76 2.86e-62 Headache; CRC cis rs10927875 0.632 rs7535248 chr1:16129598 C/T cg21385522 chr1:16154831 NA -1.07 -17.43 -0.69 1.18e-48 Dilated cardiomyopathy; CRC cis rs561341 0.714 rs547473 chr17:30297560 T/G cg00745463 chr17:30367425 LRRC37B -0.75 -9.09 -0.45 9.8e-18 Hip circumference adjusted for BMI; CRC cis rs2404602 1.000 rs12898430 chr15:76874923 G/A cg03037974 chr15:76606532 NA 0.59 9.78 0.47 5.24e-20 Blood metabolite levels; CRC cis rs6951245 1.000 rs11766526 chr7:1101433 G/A cg04025307 chr7:1156635 C7orf50 0.64 6.81 0.35 4.53e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs6840360 0.615 rs12647616 chr4:152607662 G/A cg09659197 chr4:152720779 NA 0.4 7.84 0.4 6.54e-14 Intelligence (multi-trait analysis); CRC cis rs6502050 0.835 rs12051747 chr17:80114814 T/C cg09264619 chr17:80180166 NA -0.35 -5.99 -0.31 5.59e-9 Life satisfaction; CRC cis rs2380220 0.751 rs117986000 chr6:95923454 A/C cg04719120 chr6:96025338 MANEA -0.53 -5.81 -0.31 1.44e-8 Behavioural disinhibition (generation interaction); CRC cis rs9914988 0.943 rs4795459 chr17:27113726 G/C cg16670446 chr17:27188758 MIR451;MIR144 0.55 8.52 0.43 5.75e-16 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs9467711 0.606 rs9393712 chr6:26371000 G/C cg16898833 chr6:26189333 HIST1H4D 0.76 6.58 0.34 1.88e-10 Autism spectrum disorder or schizophrenia; CRC cis rs7591163 1.000 rs6744308 chr2:228711816 T/G cg14646075 chr2:228736089 WDR69 -0.45 -6.14 -0.32 2.43e-9 Blood pressure; CRC cis rs6668534 1.000 rs6668534 chr1:161671995 C/T cg17887793 chr1:161494110 HSPA6 -0.69 -8.48 -0.42 7.95e-16 Blood protein levels; CRC cis rs3820068 0.603 rs72645887 chr1:15929905 G/C cg24675056 chr1:15929824 NA 0.49 6.77 0.35 5.87e-11 Systolic blood pressure; CRC cis rs79349575 0.749 rs46521 chr17:46988529 A/G cg22482690 chr17:47019901 SNF8 0.48 8.06 0.41 1.48e-14 Type 2 diabetes; CRC cis rs6496667 1.000 rs4261510 chr15:90890606 G/A cg04176472 chr15:90893244 GABARAPL3 0.65 8.93 0.44 3.16e-17 Rheumatoid arthritis; CRC cis rs10504073 0.584 rs55838473 chr8:49948281 C/A cg00325661 chr8:49890786 NA 0.59 10.66 0.51 5.37e-23 Blood metabolite ratios; CRC cis rs4065321 0.522 rs34648856 chr17:38149411 G/A cg17344932 chr17:38183730 MED24;SNORD124 0.85 16.8 0.68 3.47e-46 White blood cell count (basophil);White blood cell count; CRC cis rs11209185 0.509 rs1938424 chr1:68431722 A/G cg22082780 chr1:68452167 NA -0.38 -5.77 -0.3 1.85e-8 Itch intensity from mosquito bite adjusted by bite size; CRC cis rs2302190 0.882 rs11656888 chr17:56546725 T/A cg25885038 chr17:56607967 SEPT4 -0.51 -7.52 -0.38 5.36e-13 Vitamin D levels; CRC cis rs10504229 1.000 rs66731170 chr8:58187895 C/G cg02725872 chr8:58115012 NA -0.38 -6.43 -0.33 4.44e-10 Developmental language disorder (linguistic errors); CRC cis rs6545883 1.000 rs778758 chr2:61782161 T/C cg15711740 chr2:61764176 XPO1 -0.53 -7.21 -0.37 3.9e-12 Tuberculosis; CRC cis rs6502050 0.799 rs4789681 chr17:80100546 G/A cg13198984 chr17:80129470 CCDC57 0.46 8.16 0.41 6.94e-15 Life satisfaction; CRC cis rs2811415 0.597 rs9857492 chr3:127763522 A/G cg13719885 chr3:127795394 NA -0.39 -5.99 -0.31 5.56e-9 Lung function (FEV1/FVC); CRC trans rs887829 0.694 rs6749496 chr2:234624286 T/C cg14520829 chr3:18390388 SATB1 0.4 6.25 0.33 1.29e-9 Metabolic traits;Bilirubin levels;Cholelithiasis-related traits in sickle cell anemia;Metabolite levels;Total bilirubin levels in HIV-1 infection;Serum metabolite levels;Blood metabolite levels; CRC cis rs6541297 1.000 rs6665260 chr1:230279067 G/T cg20703242 chr1:230279135 GALNT2 0.51 8.0 0.4 2.21e-14 Coronary artery disease; CRC cis rs10256972 0.732 rs12701856 chr7:1107707 C/T cg03188948 chr7:1209495 NA 0.42 6.05 0.32 3.98e-9 Longevity;Endometriosis; CRC cis rs72781680 0.898 rs113027486 chr2:24098371 G/A cg08917208 chr2:24149416 ATAD2B 0.89 9.04 0.45 1.4e-17 Lymphocyte counts; CRC cis rs9303280 0.773 rs12949100 chr17:38057189 G/A cg00129232 chr17:37814104 STARD3 -0.46 -7.19 -0.37 4.44e-12 Self-reported allergy; CRC trans rs2228479 0.850 rs2286393 chr16:89809548 C/A cg24644049 chr4:85504048 CDS1 0.89 7.31 0.37 2.07e-12 Skin colour saturation; CRC cis rs2882667 0.858 rs11741150 chr5:138431457 C/T cg09476006 chr5:138032270 NA 0.44 6.78 0.35 5.56e-11 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs4332037 0.722 rs4719331 chr7:1914679 A/C cg24505167 chr7:1915268 MAD1L1 -0.48 -7.31 -0.37 2.08e-12 Bipolar disorder; CRC cis rs244731 0.959 rs918459 chr5:176669030 C/T cg06060754 chr5:176797920 RGS14 -0.57 -7.64 -0.39 2.34e-13 Urate levels in lean individuals; CRC cis rs755249 0.532 rs2296173 chr1:39913351 A/G cg18385671 chr1:39797026 MACF1 -0.4 -5.7 -0.3 2.71e-8 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs1005277 0.579 rs2474567 chr10:38382492 C/T cg00409905 chr10:38381863 ZNF37A -0.68 -11.32 -0.53 2.61e-25 Extrinsic epigenetic age acceleration; CRC cis rs1355223 0.583 rs1549789 chr11:34867947 G/A cg24088639 chr11:34937564 PDHX;APIP -0.57 -8.27 -0.41 3.38e-15 Systemic lupus erythematosus and Systemic sclerosis; CRC cis rs11764590 0.950 rs55683212 chr7:2078855 G/C cg24505167 chr7:1915268 MAD1L1 -0.42 -5.92 -0.31 8.3e-9 Neuroticism; CRC cis rs1577917 0.917 rs12665464 chr6:86574133 C/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.5 -6.45 -0.34 3.96e-10 Response to antipsychotic treatment; CRC cis rs2204008 0.630 rs1283300 chr12:38150227 C/T cg13010199 chr12:38710504 ALG10B -0.41 -5.99 -0.31 5.54e-9 Bladder cancer; CRC cis rs4481887 0.741 rs6587471 chr1:248560741 C/T cg26353448 chr1:248524236 OR2T4 -0.31 -5.81 -0.31 1.47e-8 Common traits (Other); CRC cis rs225245 0.817 rs1634684 chr17:33941051 A/G cg05299278 chr17:33885742 SLFN14 0.48 8.02 0.4 1.9e-14 Reticulocyte count;Reticulocyte fraction of red cells;High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells; CRC cis rs2455601 0.638 rs2248245 chr11:8988350 G/A cg09997546 chr11:8931473 C11orf17;ST5 -0.43 -6.0 -0.31 5.19e-9 Schizophrenia; CRC cis rs10504229 0.683 rs56211106 chr8:58113497 A/G cg04204079 chr8:58130323 NA -0.45 -5.84 -0.31 1.27e-8 Developmental language disorder (linguistic errors); CRC cis rs9910055 0.659 rs7216294 chr17:42251095 T/C cg09913183 chr17:42254507 C17orf65;ASB16 0.65 10.13 0.49 3.62e-21 Total body bone mineral density; CRC cis rs3617 0.573 rs3821873 chr3:52913006 C/T cg11645453 chr3:52864694 ITIH4 -0.36 -6.91 -0.36 2.51e-11 Red blood cell count;Autism spectrum disorder or schizophrenia; CRC cis rs977987 0.778 rs11862719 chr16:75431708 T/A cg03315344 chr16:75512273 CHST6 0.54 9.0 0.44 1.86e-17 Dupuytren's disease; CRC cis rs4713118 0.738 rs200465 chr6:27757654 T/A cg15845792 chr6:28175446 NA 0.68 8.93 0.44 2.99e-17 Parkinson's disease; CRC cis rs59104589 0.517 rs3821281 chr2:242385340 A/G cg19488206 chr2:242435732 STK25 0.49 7.12 0.37 6.65e-12 Fibrinogen levels; CRC cis rs10208940 0.920 rs35005506 chr2:68814238 A/T cg12452813 chr2:68675892 NA 0.48 6.0 0.31 5.28e-9 Urate levels in lean individuals; CRC cis rs4665809 0.590 rs6716858 chr2:26423414 G/A cg22920501 chr2:26401640 FAM59B -0.69 -10.21 -0.49 1.87e-21 Gut microbiome composition (summer); CRC cis rs919433 1.000 rs2889363 chr2:198163699 A/G cg03934865 chr2:198174659 NA -0.44 -7.77 -0.39 1.01e-13 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC cis rs2457480 0.866 rs7079375 chr10:44730310 T/C cg09554077 chr10:44749378 NA 0.65 7.41 0.38 1.07e-12 Coronary artery disease; CRC cis rs6502050 0.835 rs62078304 chr17:80085224 G/A cg09264619 chr17:80180166 NA 0.38 6.44 0.33 4.28e-10 Life satisfaction; CRC cis rs798554 0.959 rs798528 chr7:2772431 A/C cg14895029 chr7:2775587 GNA12 -0.48 -6.96 -0.36 1.87e-11 Height; CRC cis rs853679 0.657 rs1778482 chr6:28240992 G/C cg21251018 chr6:28226885 NKAPL 0.5 8.2 0.41 5.34e-15 Depression; CRC cis rs8060686 0.565 rs8044328 chr16:68146859 G/C cg08314208 chr16:67682810 RLTPR -0.49 -5.88 -0.31 1.01e-8 HDL cholesterol;Metabolic syndrome; CRC cis rs7811142 0.830 rs11768967 chr7:99967644 G/A cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.75 10.58 0.5 1.02e-22 Platelet count; CRC cis rs10883723 0.810 rs17782574 chr10:104279394 G/A cg04362960 chr10:104952993 NT5C2 -0.4 -5.6 -0.3 4.46e-8 Allergic disease (asthma, hay fever or eczema); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg02867650 chr6:11094066 LOC221710 0.47 6.51 0.34 2.79e-10 Response to antipsychotic treatment; CRC cis rs1873147 0.569 rs8034365 chr15:63309203 C/T cg12160578 chr15:63334699 TPM1 0.61 7.22 0.37 3.62e-12 Orofacial clefts; CRC cis rs7632954 0.867 rs11715189 chr3:8517861 C/T cg03495237 chr3:8533978 NA 0.34 5.87 0.31 1.06e-8 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs5758659 0.714 rs6002607 chr22:42496506 C/T cg25452165 chr22:42524984 CYP2D6 -0.4 -5.72 -0.3 2.34e-8 Cognitive function; CRC cis rs4148883 0.504 rs28720150 chr4:100132790 T/G cg12011299 chr4:100065546 ADH4 -0.39 -8.52 -0.43 5.72e-16 Alcohol dependence; CRC cis rs6484504 0.576 rs11031324 chr11:31250299 T/C cg14844989 chr11:31128820 NA -0.34 -6.02 -0.31 4.75e-9 Red blood cell count; CRC cis rs1008375 0.897 rs2315554 chr4:17660407 T/C cg16339924 chr4:17578868 LAP3 0.51 6.39 0.33 5.75e-10 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs9911578 0.935 rs9911753 chr17:56983174 G/A cg12560992 chr17:57184187 TRIM37 0.82 14.34 0.62 1.44e-36 Intelligence (multi-trait analysis); CRC trans rs6600671 1.000 rs12047116 chr1:121185770 G/A cg09829573 chr1:144692074 NBPF9 -0.4 -5.99 -0.31 5.47e-9 Hip geometry; CRC cis rs1046896 0.731 rs9906115 chr17:80791469 G/A cg02711726 chr17:80685570 FN3KRP -0.53 -7.09 -0.36 8.02e-12 Glycated hemoglobin levels; CRC cis rs6952808 0.692 rs11773316 chr7:2027354 C/T cg18279126 chr7:2041391 MAD1L1 0.39 5.75 0.3 2.04e-8 Bipolar disorder and schizophrenia; CRC trans rs6561151 0.681 rs10507521 chr13:44441834 C/G cg12856521 chr11:46389249 DGKZ -0.72 -10.85 -0.51 1.18e-23 Crohn's disease; CRC cis rs2204008 0.818 rs7313608 chr12:38383428 C/A cg26384229 chr12:38710491 ALG10B -0.64 -9.58 -0.47 2.45e-19 Bladder cancer; CRC cis rs1209950 0.512 rs374575 chr21:40193914 C/T cg02119577 chr21:40195074 ETS2 -0.37 -5.74 -0.3 2.2e-8 Non-small cell lung cancer (survival); CRC cis rs6585424 0.778 rs12257082 chr10:81922121 C/G cg11900509 chr10:81946545 ANXA11 -0.72 -8.81 -0.44 7.22e-17 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs9549367 0.789 rs6577034 chr13:113879900 T/C cg00898013 chr13:113819073 PROZ -0.42 -6.28 -0.33 1.08e-9 Platelet distribution width; CRC cis rs9368481 0.729 rs9379948 chr6:26944783 T/G cg05192639 chr6:26864778 GUSBL1 0.33 6.01 0.31 4.96e-9 Autism spectrum disorder or schizophrenia; CRC cis rs8180040 0.726 rs4078466 chr3:47126543 C/T cg27129171 chr3:47204927 SETD2 0.76 13.11 0.59 6.83e-32 Colorectal cancer; CRC cis rs4728302 0.869 rs10808273 chr7:133597691 G/C cg10665199 chr7:133106180 EXOC4 0.38 5.77 0.3 1.8e-8 Intelligence;Intelligence (multi-trait analysis); CRC cis rs2565722 0.622 rs2489944 chr6:161292913 C/T cg03159191 chr6:161285451 NA -0.45 -6.0 -0.31 5.24e-9 Blood protein levels; CRC cis rs9325144 0.555 rs12424003 chr12:38688140 C/T cg13010199 chr12:38710504 ALG10B -0.44 -6.28 -0.33 1.1e-9 Morning vs. evening chronotype; CRC cis rs597539 0.654 rs7107137 chr11:68623712 A/G cg21963583 chr11:68658836 MRPL21 0.59 10.22 0.49 1.74e-21 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs2180341 0.695 rs6569487 chr6:127726196 C/T cg27446573 chr6:127587934 RNF146 -0.59 -8.39 -0.42 1.42e-15 Breast cancer; CRC cis rs3736485 0.932 rs8037167 chr15:51918126 G/T cg08986416 chr15:51914746 DMXL2 -0.47 -6.62 -0.34 1.47e-10 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs2239547 0.522 rs9842974 chr3:53011050 C/A cg10802521 chr3:52805072 NEK4 -0.43 -5.92 -0.31 8.06e-9 Schizophrenia; CRC cis rs6662572 0.737 rs10789477 chr1:46306583 A/G cg08644498 chr1:46502608 NA -0.42 -6.49 -0.34 3.22e-10 Blood protein levels; CRC cis rs9326248 0.953 rs488962 chr11:117072525 C/T cg26566898 chr11:117069891 TAGLN -0.44 -9.44 -0.46 6.83e-19 Blood protein levels; CRC cis rs3820068 0.532 rs74057713 chr1:15944620 G/C cg24675056 chr1:15929824 NA 0.48 6.62 0.34 1.49e-10 Systolic blood pressure; CRC cis rs7552404 0.731 rs17650138 chr1:76398887 C/T cg22875332 chr1:76189707 ACADM -0.6 -7.31 -0.37 2.09e-12 Blood metabolite levels;Acylcarnitine levels; CRC cis rs10504229 0.953 rs116564484 chr8:58172818 T/C cg02725872 chr8:58115012 NA -0.39 -6.78 -0.35 5.63e-11 Developmental language disorder (linguistic errors); CRC cis rs9992667 0.955 rs1962053 chr4:38612357 A/C cg19726192 chr4:38663646 FLJ13197 -0.59 -7.67 -0.39 1.95e-13 Eosinophil percentage of granulocytes; CRC trans rs10242455 0.702 rs17161726 chr7:99008395 C/G cg09045935 chr12:6379348 NA 0.9 7.86 0.4 5.68e-14 Blood metabolite levels; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg04824595 chr19:58987622 ZNF446 0.47 6.56 0.34 2.09e-10 Response to antipsychotic treatment; CRC cis rs7249142 0.526 rs7256811 chr19:19283551 A/G cg26504305 chr19:19281019 LOC729991-MEF2B;MEF2B -0.44 -8.85 -0.44 5.31e-17 IgG glycosylation; CRC cis rs10450586 0.829 rs7105320 chr11:27306168 A/G cg10370305 chr11:27303972 NA 0.37 6.02 0.31 4.69e-9 Total body bone mineral density; CRC trans rs10982213 0.830 rs2274163 chr9:117188714 C/T cg20713130 chr11:46260756 NA 0.41 6.21 0.32 1.59e-9 Interleukin-6 levels; CRC cis rs2976388 0.590 rs11785290 chr8:143814849 A/G cg10596483 chr8:143751796 JRK -0.44 -6.27 -0.33 1.15e-9 Urinary tract infection frequency; CRC trans rs7615952 0.512 rs2979334 chr3:125358824 G/A cg08546805 chr12:8549446 NA -0.43 -6.55 -0.34 2.26e-10 Blood pressure (smoking interaction); CRC cis rs9381040 0.610 rs2057002 chr6:41022962 G/T cg09580153 chr6:41068724 NFYA;LOC221442 -0.43 -6.21 -0.32 1.55e-9 Alzheimer's disease (late onset); CRC cis rs7119 0.689 rs11630557 chr15:77820712 A/G cg27398640 chr15:77910606 LINGO1 -0.45 -7.97 -0.4 2.6e-14 Type 2 diabetes; CRC cis rs10788264 0.504 rs4751886 chr10:124020396 T/C cg09507567 chr10:124027408 NA 0.35 7.52 0.38 5.1e-13 Total body bone mineral density; CRC cis rs2749592 0.550 rs12255038 chr10:37869332 T/C cg25427524 chr10:38739819 LOC399744 0.66 10.99 0.52 3.81e-24 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs4908768 0.501 rs11121199 chr1:8600192 G/A cg20416874 chr1:8611966 RERE -0.44 -6.4 -0.33 5.26e-10 Neuroticism (multi-trait analysis);Subjective well-being (multi-trait analysis); CRC cis rs7833790 0.632 rs6473308 chr8:82707708 G/A cg27398817 chr8:82754497 SNX16 -0.43 -5.79 -0.3 1.61e-8 Diastolic blood pressure; CRC cis rs11148252 0.875 rs7987115 chr13:52962097 C/T cg00495681 chr13:53174319 NA 0.51 7.75 0.39 1.15e-13 Lewy body disease; CRC cis rs875971 0.545 rs73146609 chr7:65767464 A/G cg18876405 chr7:65276391 NA 0.46 6.44 0.33 4.29e-10 Aortic root size; CRC trans rs2055729 0.645 rs12543996 chr8:9742666 C/T cg06636001 chr8:8085503 FLJ10661 -0.6 -7.55 -0.38 4.23e-13 Multiple myeloma (hyperdiploidy); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg10722636 chr22:41252884 XPNPEP3;ST13 0.42 6.37 0.33 6.27e-10 Liver disease severity in Alagille syndrome; CRC trans rs9329221 0.620 rs6601427 chr8:10156025 A/G cg16141378 chr3:129829833 LOC729375 0.45 6.75 0.35 6.57e-11 Neuroticism; CRC trans rs2228479 0.850 rs62054640 chr16:89823157 C/T cg24644049 chr4:85504048 CDS1 0.86 6.93 0.36 2.29e-11 Skin colour saturation; CRC cis rs9611565 0.512 rs4512 chr22:42206084 G/C cg06634786 chr22:41940651 POLR3H -0.7 -7.68 -0.39 1.86e-13 Vitiligo; CRC cis rs2836974 0.831 rs2836964 chr21:40631006 T/C cg06238570 chr21:40685208 BRWD1 0.79 10.85 0.51 1.17e-23 Cognitive function; CRC cis rs28386778 0.897 rs7210443 chr17:61785374 A/G cg06601766 chr17:61851465 DDX42;CCDC47 0.45 6.04 0.32 4.06e-9 Prudent dietary pattern; CRC cis rs3956705 0.798 rs6462427 chr7:32907344 T/C cg05721444 chr7:32995514 FKBP9 -0.45 -6.49 -0.34 3.24e-10 Red cell distribution width; CRC cis rs11212617 0.967 rs3781869 chr11:108059000 T/C cg12106634 chr11:108092400 ATM;NPAT 0.39 5.69 0.3 2.86e-8 Response to metformin in type 2 diabetes (glycemic); CRC cis rs7762018 0.941 rs4716384 chr6:170109184 T/A cg19338460 chr6:170058176 WDR27 -0.72 -7.83 -0.4 6.94e-14 Thiazide-induced adverse metabolic effects in hypertensive patients; CRC cis rs1178968 1.000 rs4273741 chr7:72773966 C/A cg25889504 chr7:72793014 NA 0.54 6.12 0.32 2.63e-9 Triglyceride levels; CRC cis rs2160860 0.773 rs10958574 chr8:39798041 G/A cg11363097 chr8:39792086 IDO2 -0.43 -7.3 -0.37 2.19e-12 Blood metabolite levels; CRC cis rs1976403 0.633 rs1697422 chr1:21821897 T/C cg17800788 chr1:21766015 NBPF3 0.4 6.86 0.35 3.45e-11 Liver enzyme levels (alkaline phosphatase); CRC cis rs1799949 1.000 rs12951869 chr17:41187567 T/G cg01879757 chr17:41196368 BRCA1 -0.41 -6.06 -0.32 3.7e-9 Menopause (age at onset); CRC cis rs16937 0.662 rs10900472 chr1:205181526 A/G cg24159697 chr1:205181237 DSTYK -0.33 -5.91 -0.31 8.33e-9 Schizophrenia; CRC cis rs5753618 0.509 rs5749229 chr22:31587218 T/C cg07713946 chr22:31675144 LIMK2 -0.39 -5.62 -0.3 4e-8 Colorectal cancer; CRC cis rs5760092 0.755 rs915589 chr22:24261004 C/T cg23131131 chr22:24373011 LOC391322 0.53 5.63 0.3 3.79e-8 Urinary 1,3-butadiene metabolite levels in smokers; CRC cis rs9584850 0.834 rs7339274 chr13:99120272 A/G cg20487152 chr13:99095054 FARP1 -0.41 -5.99 -0.31 5.42e-9 Neuroticism; CRC cis rs10479542 0.544 rs7706275 chr5:178990305 A/G cg00080972 chr5:178986291 RUFY1 0.46 7.92 0.4 3.64e-14 Lung cancer; CRC cis rs2658782 0.789 rs3019206 chr11:93111073 A/G cg15737290 chr11:93063684 CCDC67 0.44 6.45 0.34 4.01e-10 Pulmonary function decline; CRC cis rs7447593 0.666 rs10866705 chr5:176801131 G/T cg16006841 chr5:176797999 RGS14 -0.67 -11.17 -0.52 8.81e-25 Urinary electrolytes (magnesium/calcium ratio); CRC cis rs55702914 0.712 rs10931778 chr2:198148922 C/T cg10820045 chr2:198174542 NA -0.43 -7.93 -0.4 3.51e-14 Major depression and alcohol dependence; CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg09698166 chr20:21106763 PLK1S1 -0.5 -6.14 -0.32 2.44e-9 Diisocyanate-induced asthma; CRC cis rs344364 0.511 rs2982447 chr16:1947413 C/T cg00046913 chr16:1877150 HAGH;FAHD1 0.55 5.76 0.3 1.95e-8 Glomerular filtration rate in chronic kidney disease; CRC cis rs736408 0.634 rs11717836 chr3:52807736 A/G cg10802521 chr3:52805072 NEK4 -0.58 -8.67 -0.43 1.94e-16 Bipolar disorder; CRC cis rs2153535 0.580 rs7767926 chr6:8453557 A/G cg21535247 chr6:8435926 SLC35B3 0.5 7.46 0.38 7.85e-13 Motion sickness; CRC cis rs853679 0.513 rs9468296 chr6:28113730 A/G cg12273811 chr6:28175739 NA 0.73 9.16 0.45 5.8e-18 Depression; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg15747848 chr15:40074985 FSIP1 0.45 6.24 0.33 1.32e-9 Response to antipsychotic treatment; CRC cis rs11105298 0.891 rs11105287 chr12:89829470 C/T cg08166232 chr12:89918718 WDR51B;GALNT4 -0.48 -6.22 -0.32 1.53e-9 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; CRC cis rs477692 0.905 rs544217 chr10:131420584 A/G cg26102564 chr10:131424627 MGMT 0.38 5.63 0.3 3.9e-8 Response to temozolomide; CRC cis rs1223397 0.651 rs2439541 chr6:13310567 T/C cg20827128 chr6:13274284 PHACTR1 0.38 5.8 0.3 1.52e-8 Blood pressure; CRC cis rs174551 1 rs174551 chr11:61573684 T/C cg06781209 chr11:61594997 FADS2 -0.38 -5.74 -0.3 2.11e-8 LDL cholesterol; CRC cis rs10883723 0.810 rs10883728 chr10:104269301 A/G cg11453585 chr10:104263688 ACTR1A;SUFU -0.88 -16.34 -0.67 2.41e-44 Allergic disease (asthma, hay fever or eczema); CRC cis rs877282 0.947 rs7475589 chr10:767479 C/G cg17470449 chr10:769945 NA 0.65 8.4 0.42 1.31e-15 Uric acid levels; CRC cis rs1799949 0.965 rs4793234 chr17:41436183 A/G cg25072359 chr17:41440525 NA 0.42 6.27 0.33 1.14e-9 Menopause (age at onset); CRC cis rs208520 0.690 rs1351867 chr6:66760995 A/G cg07460842 chr6:66804631 NA 1.05 14.56 0.63 2.04e-37 Exhaled nitric oxide output; CRC cis rs734999 0.566 rs12748729 chr1:2558740 C/T cg18854424 chr1:2615690 NA -0.4 -7.52 -0.38 5.19e-13 Ulcerative colitis; CRC cis rs2731664 0.792 rs385981 chr5:176886539 C/T cg23176889 chr5:176863531 GRK6 -0.73 -15.81 -0.66 2.74e-42 Intelligence (multi-trait analysis); CRC cis rs4819052 0.851 rs2838831 chr21:46664775 C/T cg02159808 chr21:46707872 POFUT2;LOC642852 0.5 6.72 0.35 7.91e-11 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC trans rs10802346 0.545 rs12134404 chr1:246372144 A/G cg22732515 chr19:44031385 ETHE1 0.61 9.07 0.45 1.1e-17 Fractional exhaled nitric oxide (childhood); CRC cis rs8177253 0.965 rs8177260 chr3:133480458 T/A cg08048268 chr3:133502702 NA -0.38 -7.27 -0.37 2.57e-12 Iron status biomarkers; CRC cis rs875971 0.862 rs1167408 chr7:65556108 G/A cg12463550 chr7:65579703 CRCP -0.53 -7.55 -0.38 4.32e-13 Aortic root size; CRC cis rs9309711 0.689 rs4535075 chr2:3481716 T/C cg10845886 chr2:3471009 TTC15 -0.4 -6.29 -0.33 9.97e-10 Neurofibrillary tangles; CRC cis rs17711722 0.727 rs1880555 chr7:65432567 T/C cg11764359 chr7:65958608 NA 0.51 7.72 0.39 1.36e-13 Calcium levels; CRC cis rs10504229 0.593 rs79615400 chr8:57988740 C/T cg02725872 chr8:58115012 NA -0.53 -7.09 -0.36 8.33e-12 Developmental language disorder (linguistic errors); CRC cis rs11098499 0.691 rs12510133 chr4:120271344 A/C cg24375607 chr4:120327624 NA 0.45 7.28 0.37 2.53e-12 Corneal astigmatism; CRC cis rs1008375 1.000 rs7694020 chr4:17682597 C/T cg16339924 chr4:17578868 LAP3 0.54 7.11 0.36 7.46e-12 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs832540 0.898 rs331497 chr5:56251660 G/T cg24531977 chr5:56204891 C5orf35 0.48 7.71 0.39 1.53e-13 Coronary artery disease; CRC cis rs7680126 0.596 rs4697714 chr4:10143786 A/T cg11266682 chr4:10021025 SLC2A9 -0.41 -6.05 -0.32 4.04e-9 Urate levels in lean individuals;Urate levels in overweight individuals;Urate levels in obese individuals; CRC trans rs1656966 1.000 rs1656966 chr3:186466252 C/T cg12195820 chr8:42698243 THAP1 0.4 6.04 0.32 4.12e-9 Myopia (pathological); CRC cis rs7584330 0.554 rs7570873 chr2:238435054 G/A cg14458575 chr2:238380390 NA 0.52 6.86 0.35 3.51e-11 Prostate cancer; CRC cis rs2204008 0.811 rs2139752 chr12:38370398 C/T cg26384229 chr12:38710491 ALG10B 0.69 9.77 0.47 5.7e-20 Bladder cancer; CRC cis rs7617773 0.780 rs34523942 chr3:48342669 C/T cg11946769 chr3:48343235 NME6 0.66 9.03 0.45 1.48e-17 Coronary artery disease; CRC trans rs875971 0.660 rs2191268 chr7:66110224 C/T cg24949396 chr16:68877816 TMCO7 -0.41 -6.18 -0.32 1.92e-9 Aortic root size; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg26085966 chr14:64319812 SYNE2 0.37 6.33 0.33 8.04e-10 Liver disease severity in Alagille syndrome; CRC cis rs2839186 0.709 rs2156117 chr21:47669300 C/A cg26721908 chr21:47610096 LSS -0.36 -5.61 -0.3 4.33e-8 Testicular germ cell tumor; CRC cis rs4692589 1.000 rs4692784 chr4:170938581 A/G cg19918862 chr4:170955249 NA 0.39 6.29 0.33 9.93e-10 Anxiety disorder; CRC cis rs910187 0.591 rs13041142 chr20:45788979 C/T cg27589058 chr20:45804311 EYA2 -0.34 -6.26 -0.33 1.21e-9 Migraine; CRC cis rs7208859 0.623 rs9911784 chr17:29124580 A/C cg13385521 chr17:29058706 SUZ12P 0.74 8.44 0.42 9.97e-16 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs2404602 0.583 rs12592501 chr15:76554790 C/A cg26408565 chr15:76604113 ETFA -0.37 -5.91 -0.31 8.35e-9 Blood metabolite levels; CRC cis rs514406 0.607 rs11206000 chr1:53205923 A/C cg08859206 chr1:53392774 SCP2 0.41 6.49 0.34 3.23e-10 Monocyte count; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg12187437 chr12:66524584 LLPH 0.46 6.04 0.32 4.15e-9 Thyroid stimulating hormone; CRC cis rs9467711 0.591 rs9461222 chr6:25905111 G/A cg16898833 chr6:26189333 HIST1H4D 0.63 5.78 0.3 1.77e-8 Autism spectrum disorder or schizophrenia; CRC cis rs875971 0.505 rs1167386 chr7:65513096 G/A cg11764359 chr7:65958608 NA -0.53 -8.12 -0.41 9.37e-15 Aortic root size; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg02878701 chr21:47706221 MCM3AP;C21orf57 0.37 6.19 0.32 1.83e-9 Liver disease severity in Alagille syndrome; CRC cis rs10504229 0.562 rs2014516 chr8:58128288 C/A cg24829409 chr8:58192753 C8orf71 -0.55 -8.03 -0.4 1.71e-14 Developmental language disorder (linguistic errors); CRC cis rs4953076 0.573 rs7593987 chr2:44393532 C/T cg04920474 chr2:44395004 PPM1B -0.57 -7.9 -0.4 4.3e-14 Height; CRC cis rs67478160 0.643 rs2295145 chr14:104202304 G/A cg08213375 chr14:104286397 PPP1R13B 0.66 13.79 0.61 1.86e-34 Schizophrenia; CRC cis rs6424115 0.830 rs2501423 chr1:24199026 A/C cg10978503 chr1:24200527 CNR2 0.6 11.01 0.52 3.33e-24 Immature fraction of reticulocytes; CRC cis rs362272 0.505 rs13104157 chr4:3366950 T/C cg11522145 chr4:3412961 RGS12 -0.39 -5.99 -0.31 5.6e-9 Serum sulfate level; CRC cis rs78456975 1.000 rs10177095 chr2:1570976 C/A cg12573674 chr2:1569213 NA -0.74 -7.89 -0.4 4.59e-14 Placebo response in major depressive disorder (% change in symptom score); CRC cis rs1552244 1.000 rs17032299 chr3:10087638 C/T cg13047869 chr3:10149882 C3orf24 0.56 7.84 0.4 6.16e-14 Alzheimer's disease; CRC cis rs17818399 0.962 rs7565274 chr2:46841861 G/T cg02822958 chr2:46747628 ATP6V1E2 0.41 5.66 0.3 3.25e-8 Height; CRC cis rs4481887 0.741 rs28589987 chr1:248564785 T/C cg26353448 chr1:248524236 OR2T4 -0.3 -5.71 -0.3 2.55e-8 Common traits (Other); CRC cis rs7618915 0.501 rs2336146 chr3:52626646 A/G cg18404041 chr3:52824283 ITIH1 -0.41 -8.61 -0.43 3.02e-16 Bipolar disorder; CRC cis rs477895 0.653 rs11603212 chr11:63927810 C/T cg18225595 chr11:63971243 STIP1 -0.59 -7.67 -0.39 1.92e-13 Mean platelet volume; CRC cis rs6810498 0.800 rs2007354 chr4:26052969 C/T cg12925881 chr4:26050407 NA -0.41 -7.66 -0.39 2.09e-13 Alcohol dependence; CRC cis rs1832871 0.521 rs878585 chr6:158815897 C/T cg14153777 chr6:158651016 NA 0.4 5.63 0.3 3.93e-8 Height; CRC cis rs10504229 0.953 rs67886764 chr8:58187117 T/C cg01721255 chr8:58191610 C8orf71 0.49 6.17 0.32 2e-9 Developmental language disorder (linguistic errors); CRC cis rs370915 0.928 rs433477 chr4:187814866 C/G cg12892747 chr4:187813459 NA 0.38 5.8 0.3 1.58e-8 Gout; CRC cis rs10504229 0.817 rs10504230 chr8:58197150 A/G cg22535103 chr8:58192502 C8orf71 0.67 8.21 0.41 5.05e-15 Developmental language disorder (linguistic errors); CRC trans rs2976388 0.573 rs1529865 chr8:143789171 C/T cg24628676 chr5:59189846 PDE4D -0.3 -6.08 -0.32 3.3e-9 Urinary tract infection frequency; CRC cis rs79349575 0.783 rs12453374 chr17:46994846 G/C cg22482690 chr17:47019901 SNF8 0.48 8.01 0.4 2.05e-14 Type 2 diabetes; CRC cis rs3820068 0.603 rs3766163 chr1:15986547 T/C cg24675056 chr1:15929824 NA 0.53 7.06 0.36 1.02e-11 Systolic blood pressure; CRC cis rs7209700 0.547 rs7219925 chr17:45341640 G/C cg17185639 chr17:45330862 ITGB3 0.37 5.73 0.3 2.25e-8 IgG glycosylation; CRC cis rs8058578 1.000 rs7204278 chr16:30730274 A/G cg02466173 chr16:30829666 NA -0.78 -12.32 -0.56 6.09e-29 Multiple myeloma; CRC trans rs6703335 0.870 rs10803142 chr1:243598234 A/G cg14743055 chr21:43430222 ZNF295 0.44 6.15 0.32 2.24e-9 Schizophrenia;Schizophrenia, schizoaffective disorder or bipolar disorder; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg11158239 chr12:7037742 ATN1 0.42 6.57 0.34 1.95e-10 Liver disease severity in Alagille syndrome; CRC cis rs2011503 1.000 rs113527843 chr19:19643343 A/T cg11584989 chr19:19387371 SF4 0.59 6.53 0.34 2.48e-10 Bipolar disorder; CRC cis rs4481887 0.927 rs12044126 chr1:248481952 T/C cg00666640 chr1:248458726 OR2T12 0.49 8.34 0.42 2.08e-15 Common traits (Other); CRC cis rs939658 0.728 rs11637459 chr15:79413554 A/G cg17916960 chr15:79447300 NA -0.4 -6.27 -0.33 1.12e-9 Refractive error; CRC cis rs66782572 1 rs66782572 chr3:52567617 A/G cg10802521 chr3:52805072 NEK4 -0.43 -6.84 -0.35 3.95e-11 Hemoglobin concentration; CRC trans rs916888 0.773 rs538628 chr17:44787313 G/C cg22968622 chr17:43663579 NA 1.38 16.84 0.68 2.53e-46 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs7493 1.000 rs12155103 chr7:95037131 G/A cg20119798 chr7:94954144 PON1 -0.48 -6.19 -0.32 1.83e-9 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs873946 0.648 rs12767126 chr10:134556992 C/T cg27286337 chr10:134555280 INPP5A 0.84 10.25 0.49 1.42e-21 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CRC trans rs703108 0.731 rs7898954 chr10:22323646 A/G cg17091793 chr13:49684397 FNDC3A -0.49 -6.02 -0.31 4.58e-9 Monocyte percentage of white cells; CRC cis rs9911578 1.000 rs999431 chr17:56854441 A/G cg05425664 chr17:57184151 TRIM37 -0.47 -7.4 -0.38 1.13e-12 Intelligence (multi-trait analysis); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg25704110 chr12:4967040 NA 0.47 6.63 0.34 1.34e-10 Response to antipsychotic treatment; CRC cis rs6089584 0.586 rs1079755 chr20:60615262 G/A cg06108461 chr20:60628389 TAF4 -0.73 -11.74 -0.54 8.22e-27 Body mass index; CRC cis rs6121246 0.779 rs6060763 chr20:30282223 A/G cg13852791 chr20:30311386 BCL2L1 0.7 11.68 0.54 1.38e-26 Mean corpuscular hemoglobin; CRC trans rs9650657 0.589 rs6985109 chr8:10761585 A/G cg06636001 chr8:8085503 FLJ10661 0.64 8.97 0.44 2.38e-17 Neuroticism; CRC trans rs916888 0.773 rs199535 chr17:44822662 A/G cg01341218 chr17:43662625 NA 0.93 10.18 0.49 2.4e-21 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs7517126 1.000 rs6428368 chr1:196844310 T/C cg13682187 chr1:196946512 CFHR5 -0.41 -6.51 -0.34 2.85e-10 Blood protein levels; CRC cis rs2811415 0.597 rs9848345 chr3:127779220 C/T cg13719885 chr3:127795394 NA -0.39 -5.95 -0.31 6.69e-9 Lung function (FEV1/FVC); CRC cis rs7412746 0.611 rs1889741 chr1:150869045 T/C cg15448220 chr1:150897856 SETDB1 0.46 6.78 0.35 5.42e-11 Melanoma; CRC cis rs13315871 0.929 rs11130628 chr3:58315835 T/C cg20936604 chr3:58311152 NA -0.74 -7.74 -0.39 1.2e-13 Cholesterol, total; CRC cis rs3820068 0.581 rs72645881 chr1:15928203 C/T cg24675056 chr1:15929824 NA 0.49 6.77 0.35 5.87e-11 Systolic blood pressure; CRC cis rs6763159 1.000 rs6808992 chr3:59649558 A/G cg07069742 chr3:59644285 NA -0.36 -7.27 -0.37 2.58e-12 Conotruncal heart defects; CRC cis rs13256369 0.851 rs13267036 chr8:8566685 G/A cg06671706 chr8:8559999 CLDN23 0.63 9.14 0.45 6.38e-18 Obesity-related traits; CRC cis rs1577917 0.771 rs12205013 chr6:86333029 C/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.71 -9.36 -0.46 1.29e-18 Response to antipsychotic treatment; CRC cis rs8180040 0.652 rs13077398 chr3:47011120 G/C cg02527881 chr3:46936655 PTH1R -0.43 -8.04 -0.41 1.58e-14 Colorectal cancer; CRC cis rs7208859 0.673 rs7211776 chr17:29120196 T/G cg01831904 chr17:28903510 LRRC37B2 -0.51 -6.07 -0.32 3.47e-9 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs4588572 0.643 rs10063319 chr5:77758425 T/C cg11446398 chr5:77624930 NA 0.47 6.3 0.33 9.63e-10 Triglycerides; CRC trans rs10983614 1.000 rs7867776 chr9:120072627 A/G cg19440955 chr10:99609836 GOLGA7B 0.46 6.21 0.32 1.58e-9 Survival in pancreatic cancer; CRC cis rs250677 0.687 rs36046 chr5:148441257 A/C cg23229984 chr5:148520753 ABLIM3 0.49 6.8 0.35 4.85e-11 Breast cancer; CRC cis rs9435341 0.929 rs1762509 chr1:107592959 A/G cg09367891 chr1:107599246 PRMT6 -0.7 -10.17 -0.49 2.64e-21 Facial morphology (factor 21, depth of nasal alae); CRC cis rs1949733 1.000 rs2631740 chr4:8484106 C/A cg13073564 chr4:8508604 NA 0.49 7.62 0.39 2.73e-13 Response to antineoplastic agents; CRC cis rs3736485 0.934 rs28410165 chr15:51875019 C/A cg08986416 chr15:51914746 DMXL2 -0.46 -6.56 -0.34 2.11e-10 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs992157 0.560 rs1514132 chr2:219084082 C/T cg04731861 chr2:219085781 ARPC2 0.38 8.04 0.41 1.6e-14 Colorectal cancer; CRC cis rs10256972 0.616 rs7806746 chr7:1075573 A/C cg03923535 chr7:1197113 ZFAND2A 0.45 6.81 0.35 4.63e-11 Longevity;Endometriosis; CRC trans rs561341 0.769 rs8074383 chr17:30178793 C/T cg00801512 chr17:28996047 NA 0.53 6.04 0.32 4.22e-9 Hip circumference adjusted for BMI; CRC cis rs3771570 0.901 rs62190413 chr2:242417950 G/A cg21155796 chr2:242212141 HDLBP 0.63 6.8 0.35 5.04e-11 Prostate cancer; CRC cis rs6951245 1.000 rs75016635 chr7:1094121 G/A cg18402987 chr7:1209562 NA 0.67 7.26 0.37 2.83e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs875971 0.893 rs62465470 chr7:65601218 T/C cg00343986 chr7:65444356 GUSB -0.42 -5.98 -0.31 5.74e-9 Aortic root size; CRC cis rs3858526 0.834 rs7128847 chr11:6003111 C/T cg05234568 chr11:5960015 NA -0.48 -6.09 -0.32 3.21e-9 DNA methylation (variation); CRC cis rs514406 0.548 rs6670871 chr1:53212082 A/C cg27535305 chr1:53392650 SCP2 0.34 6.17 0.32 2.03e-9 Monocyte count; CRC cis rs9467773 0.620 rs2494700 chr6:26631306 C/T cg09904177 chr6:26538194 HMGN4 0.72 11.39 0.53 1.42e-25 Intelligence (multi-trait analysis); CRC cis rs6761276 0.899 rs13389457 chr2:113834885 T/C cg09040174 chr2:113837401 NA 0.65 10.31 0.49 9.07e-22 Protein quantitative trait loci; CRC cis rs10504229 1.000 rs79561699 chr8:58170601 A/G cg02725872 chr8:58115012 NA -0.39 -6.77 -0.35 5.94e-11 Developmental language disorder (linguistic errors); CRC cis rs3749237 0.964 rs11717463 chr3:49808981 C/T cg05072774 chr3:49840536 C3orf54 -0.45 -5.83 -0.31 1.35e-8 Resting heart rate; CRC cis rs2067615 0.579 rs1922435 chr12:107082455 A/G cg13491945 chr12:107078410 RFX4 0.34 5.65 0.3 3.45e-8 Heart rate; CRC cis rs7772486 0.790 rs9497435 chr6:146265340 C/A cg13319975 chr6:146136371 FBXO30 0.39 5.93 0.31 7.81e-9 Lobe attachment (rater-scored or self-reported); CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg11365449 chr11:66313673 ZDHHC24;ACTN3 -0.42 -6.07 -0.32 3.57e-9 Myopia (pathological); CRC cis rs4969178 0.932 rs3744219 chr17:76400236 G/A cg20026190 chr17:76395443 PGS1 0.38 5.68 0.3 2.95e-8 HDL cholesterol levels; CRC cis rs6547741 1.000 rs6749052 chr2:27772879 A/T cg27432699 chr2:27873401 GPN1 0.76 13.55 0.6 1.51e-33 Oral cavity cancer; CRC cis rs11098499 0.754 rs66900435 chr4:120249425 C/A cg24375607 chr4:120327624 NA 0.48 7.74 0.39 1.2e-13 Corneal astigmatism; CRC cis rs853679 0.517 rs1340004 chr6:28103691 C/T cg21251018 chr6:28226885 NKAPL 0.47 6.14 0.32 2.42e-9 Depression; CRC cis rs72627123 0.867 rs57731447 chr14:74487521 G/A cg12022184 chr14:74485813 ENTPD5;C14orf45 0.71 5.81 0.3 1.5e-8 Morning vs. evening chronotype; CRC trans rs7824557 0.524 rs7835318 chr8:10953874 G/A cg16141378 chr3:129829833 LOC729375 0.46 6.9 0.36 2.62e-11 Retinal vascular caliber; CRC cis rs6459788 0.502 rs9692347 chr7:157232659 C/T cg06271696 chr7:157225062 NA -0.71 -12.68 -0.57 2.93e-30 Epstein-Barr virus copy number in lymphoblastoid cell lines; CRC cis rs1862618 0.853 rs863840 chr5:56128999 C/G cg20203395 chr5:56204925 C5orf35 -0.67 -8.08 -0.41 1.22e-14 Initial pursuit acceleration; CRC cis rs10197940 0.624 rs17270233 chr2:152372420 A/G cg06191203 chr2:152266755 RIF1 -0.72 -10.25 -0.49 1.45e-21 Lung cancer; CRC cis rs9467773 0.933 rs35355150 chr6:26526039 G/A cg09904177 chr6:26538194 HMGN4 0.75 11.79 0.55 5.18e-27 Intelligence (multi-trait analysis); CRC cis rs11997175 0.574 rs10954931 chr8:33631066 A/T ch.8.33884649F chr8:33765107 NA 0.49 7.82 0.4 7.04e-14 Body mass index; CRC cis rs172166 0.561 rs149974 chr6:27985096 T/C cg03623178 chr6:28175578 NA 0.64 9.66 0.47 1.3e-19 Cardiac Troponin-T levels; CRC cis rs17818399 0.547 rs4952831 chr2:46761181 G/A cg21681030 chr2:46777652 RHOQ 0.45 6.05 0.32 3.98e-9 Height; CRC cis rs3767633 0.925 rs2499856 chr1:161926637 C/T cg09175582 chr1:161736000 ATF6 -0.67 -6.14 -0.32 2.33e-9 IgG glycosylation; CRC cis rs9611565 0.512 rs5751148 chr22:42139078 A/G cg03806693 chr22:41940476 POLR3H 1.08 13.41 0.59 5.35e-33 Vitiligo; CRC cis rs7615952 0.599 rs16834938 chr3:125706046 C/T cg06494592 chr3:125709126 NA -0.53 -6.49 -0.34 3.08e-10 Blood pressure (smoking interaction); CRC cis rs2976388 0.609 rs2585145 chr8:143799457 G/A cg15511327 chr8:143859410 LYNX1 0.39 6.76 0.35 6.25e-11 Urinary tract infection frequency; CRC cis rs478304 0.651 rs4014195 chr11:65506822 C/G cg27068330 chr11:65405492 SIPA1 0.61 9.06 0.45 1.23e-17 Acne (severe); CRC cis rs3806843 0.766 rs801399 chr5:140034844 C/T cg19875535 chr5:140030758 IK -0.52 -8.45 -0.42 9.5e-16 Depressive symptoms (multi-trait analysis); CRC trans rs6951245 1.000 rs76804143 chr7:1082021 C/T cg13565492 chr6:43139072 SRF -0.71 -7.27 -0.37 2.61e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs1348850 0.768 rs57681892 chr2:178357645 G/C cg22681709 chr2:178499509 PDE11A -0.41 -7.48 -0.38 7e-13 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC trans rs877282 0.583 rs11253428 chr10:823233 C/T cg22713356 chr15:30763199 NA 0.78 8.63 0.43 2.75e-16 Uric acid levels; CRC cis rs6088590 0.582 rs6059909 chr20:33139691 C/A cg08999081 chr20:33150536 PIGU 0.64 12.43 0.57 2.39e-29 Coronary artery disease; CRC cis rs2708240 0.666 rs2538962 chr7:147600604 C/A cg02373104 chr7:147601429 MIR548F3;CNTNAP2 -0.44 -6.44 -0.33 4.25e-10 QT interval (drug interaction); CRC cis rs6500395 1.000 rs2355297 chr16:48685338 T/C cg04672837 chr16:48644449 N4BP1 -0.45 -6.63 -0.34 1.38e-10 Response to tocilizumab in rheumatoid arthritis; CRC cis rs2180341 0.842 rs7739679 chr6:127545428 G/A cg27446573 chr6:127587934 RNF146 0.87 10.71 0.51 3.67e-23 Breast cancer; CRC cis rs2032447 0.798 rs807214 chr6:26061769 G/C cg03517284 chr6:25882590 NA -0.48 -6.65 -0.34 1.21e-10 Intelligence (multi-trait analysis); CRC cis rs10499694 0.933 rs11575334 chr7:50597301 G/A cg14593290 chr7:50529359 DDC -0.43 -6.34 -0.33 7.62e-10 Body mass index; CRC cis rs763121 0.889 rs2267390 chr22:38889657 C/T cg06022373 chr22:39101656 GTPBP1 0.74 11.2 0.53 6.87e-25 Menopause (age at onset); CRC cis rs10504229 0.683 rs10504223 chr8:58140944 G/A cg02290350 chr8:58132656 NA -0.58 -8.16 -0.41 7.29e-15 Developmental language disorder (linguistic errors); CRC trans rs4689592 0.546 rs10937784 chr4:7060935 G/C cg07817883 chr1:32538562 TMEM39B -0.62 -8.11 -0.41 1.03e-14 Monocyte percentage of white cells; CRC trans rs2018683 0.677 rs12540529 chr7:28969384 A/G cg19402173 chr7:128379420 CALU -0.42 -6.09 -0.32 3.07e-9 Response to irinotecan and platinum-based chemotherapy in non-small-cell lung cancer; CRC cis rs10905065 0.930 rs9423726 chr10:5737979 A/G cg11519256 chr10:5708881 ASB13 -0.45 -6.47 -0.34 3.6e-10 Menopause (age at onset); CRC cis rs7216064 1.000 rs1976054 chr17:65833224 T/G cg12091567 chr17:66097778 LOC651250 -0.64 -8.08 -0.41 1.22e-14 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CRC cis rs6964587 1.000 rs6969536 chr7:91689351 C/G cg17063962 chr7:91808500 NA 0.78 13.56 0.6 1.41e-33 Breast cancer; CRC cis rs10193935 0.901 rs6733464 chr2:42563597 A/G cg27598129 chr2:42591480 NA -0.7 -7.95 -0.4 2.96e-14 Colonoscopy-negative controls vs population controls; CRC trans rs1814175 0.669 rs10839315 chr11:49654406 G/A cg11707556 chr5:10655725 ANKRD33B -0.37 -6.85 -0.35 3.74e-11 Height; CRC cis rs2304069 0.545 rs7445660 chr5:149413610 A/C cg22760475 chr5:149380129 HMGXB3;TIGD6 0.45 6.49 0.34 3.18e-10 HIV-1 control; CRC cis rs7680126 0.633 rs55766779 chr4:10287039 C/T cg11266682 chr4:10021025 SLC2A9 -0.44 -6.68 -0.35 1.04e-10 Urate levels in lean individuals;Urate levels in overweight individuals;Urate levels in obese individuals; CRC cis rs796364 0.951 rs281776 chr2:200834282 T/G cg23649088 chr2:200775458 C2orf69 0.54 5.79 0.3 1.66e-8 Schizophrenia; CRC trans rs7395662 1.000 rs9645642 chr11:48705455 G/T cg21153622 chr11:89784906 NA -0.48 -7.73 -0.39 1.31e-13 HDL cholesterol; CRC cis rs727563 0.635 rs2899348 chr22:42164516 C/G cg06634786 chr22:41940651 POLR3H 0.66 7.3 0.37 2.18e-12 Crohn's disease;Inflammatory bowel disease; CRC cis rs798554 0.959 rs798528 chr7:2772431 A/C cg19346786 chr7:2764209 NA -0.42 -7.26 -0.37 2.74e-12 Height; CRC cis rs236352 0.576 rs3778016 chr6:36842192 C/T cg10099585 chr6:36853529 C6orf89 -0.45 -6.34 -0.33 7.47e-10 Heart rate; CRC cis rs2011503 1.000 rs45556231 chr19:19654189 G/A cg11584989 chr19:19387371 SF4 0.58 6.38 0.33 6.18e-10 Bipolar disorder; CRC cis rs28655083 0.956 rs8060627 chr16:77077065 A/G cg01753188 chr16:77233325 SYCE1L;MON1B -0.56 -7.79 -0.39 8.69e-14 Lobe attachment (rater-scored or self-reported); CRC cis rs9513627 0.573 rs4771336 chr13:100210610 T/G cg03041920 chr13:100310311 CLYBL 0.39 5.62 0.3 4e-8 Obesity-related traits; CRC cis rs2991971 0.967 rs6661321 chr1:45954599 C/G cg15605315 chr1:45957053 TESK2 0.41 6.63 0.34 1.4e-10 High light scatter reticulocyte count; CRC trans rs7613875 0.620 rs7634441 chr3:50071677 G/A cg21665057 chr3:196295764 WDR53;FBXO45 -0.47 -7.08 -0.36 8.55e-12 Body mass index; CRC cis rs875971 0.508 rs6947808 chr7:66045082 A/G cg00343986 chr7:65444356 GUSB -0.47 -7.07 -0.36 9.53e-12 Aortic root size; CRC cis rs2832191 0.720 rs4643617 chr21:30485278 T/C cg24692254 chr21:30365293 RNF160 -0.71 -12.84 -0.58 7e-31 Dental caries; CRC cis rs877282 0.891 rs11253355 chr10:768367 C/G cg17470449 chr10:769945 NA 0.65 8.4 0.42 1.31e-15 Uric acid levels; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg07907917 chr19:40949191 SERTAD3 0.48 6.12 0.32 2.59e-9 Thyroid stimulating hormone; CRC cis rs3751196 0.808 rs1437505 chr12:104216214 G/A cg02344784 chr12:104178138 NT5DC3 0.7 8.24 0.41 4.16e-15 Sense of smell; CRC cis rs9926296 0.605 rs7205053 chr16:89856763 G/C cg27121462 chr16:89883253 FANCA 0.58 9.27 0.45 2.57e-18 Vitiligo; CRC cis rs853679 0.517 rs3734573 chr6:28059437 T/C cg21251018 chr6:28226885 NKAPL 0.48 6.22 0.32 1.55e-9 Depression; CRC cis rs4290604 0.667 rs62183333 chr2:237953460 T/C cg23555395 chr2:238036564 NA 0.66 6.54 0.34 2.37e-10 Asthma; CRC cis rs7208859 0.623 rs8081299 chr17:29104296 G/A cg13385521 chr17:29058706 SUZ12P 0.74 8.39 0.42 1.47e-15 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs3924048 0.559 rs6541037 chr1:12626155 A/G cg00291366 chr1:12616550 NA 0.55 9.77 0.47 5.65e-20 Optic cup area; CRC cis rs2836974 0.829 rs34227163 chr21:40551943 A/G cg17971929 chr21:40555470 PSMG1 0.82 11.68 0.54 1.3e-26 Cognitive function; CRC cis rs4665809 0.531 rs12987980 chr2:26462093 A/T cg22920501 chr2:26401640 FAM59B 0.85 12.21 0.56 1.54e-28 Gut microbiome composition (summer); CRC cis rs17376456 0.825 rs28412976 chr5:93248377 T/C cg21475434 chr5:93447410 FAM172A 0.83 7.84 0.4 6.51e-14 Diabetic retinopathy; CRC trans rs2303319 0.504 rs62189053 chr2:162624324 G/A cg10498984 chr16:28874827 SH2B1 -0.73 -6.28 -0.33 1.04e-9 Cognitive function; CRC cis rs9916302 0.904 rs588193 chr17:37440439 A/C cg15445000 chr17:37608096 MED1 -0.43 -9.47 -0.46 5.47e-19 Glomerular filtration rate (creatinine); CRC cis rs9549328 0.527 rs9549622 chr13:113640064 A/C cg20742385 chr13:113633654 MCF2L -0.55 -6.56 -0.34 2.03e-10 Systolic blood pressure; CRC cis rs7191439 0.858 rs8044367 chr16:88783374 A/G cg27087555 chr16:88793112 FAM38A -1.39 -13.15 -0.59 4.95e-32 Plateletcrit; CRC cis rs720844 0.671 rs10928399 chr2:149277896 C/T cg09247360 chr2:149335327 NA -0.51 -6.01 -0.31 4.98e-9 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs924607 0.931 rs1709556 chr5:637058 A/G cg24163568 chr5:669837 TPPP 0.43 6.83 0.35 4.09e-11 Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia; CRC cis rs6860806 0.507 rs2631369 chr5:131705266 G/C cg11843238 chr5:131593191 PDLIM4 -0.44 -7.72 -0.39 1.41e-13 Breast cancer; CRC cis rs801193 0.967 rs1110414 chr7:66205582 A/G cg18876405 chr7:65276391 NA 0.6 10.61 0.51 7.98e-23 Aortic root size; CRC cis rs8180040 0.903 rs13094438 chr3:47277885 G/A cg27129171 chr3:47204927 SETD2 0.63 10.05 0.48 6.78e-21 Colorectal cancer; CRC cis rs924607 0.898 rs905193 chr5:635095 T/C cg04221910 chr5:616842 CEP72 0.41 6.77 0.35 5.99e-11 Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia; CRC cis rs11098499 0.866 rs12501602 chr4:120287935 A/T cg24375607 chr4:120327624 NA 0.49 7.57 0.39 3.7e-13 Corneal astigmatism; CRC trans rs11039798 0.588 rs11039781 chr11:48523085 T/G cg03929089 chr4:120376271 NA 0.64 6.6 0.34 1.62e-10 Axial length; CRC cis rs1448094 0.842 rs7966352 chr12:86438705 A/C cg02569458 chr12:86230093 RASSF9 0.39 6.55 0.34 2.18e-10 Major depressive disorder; CRC cis rs1552244 0.808 rs17032306 chr3:10091399 C/G cg08888203 chr3:10149979 C3orf24 0.7 10.01 0.48 8.99e-21 Alzheimer's disease; CRC cis rs1552244 0.554 rs34883592 chr3:10046165 C/T cg18598329 chr3:10140678 FANCD2;C3orf24 -0.53 -7.53 -0.38 4.84e-13 Alzheimer's disease; CRC cis rs12928939 0.774 rs7192860 chr16:71643622 G/A cg08717414 chr16:71523259 ZNF19 -0.46 -5.81 -0.31 1.45e-8 Post bronchodilator FEV1; CRC cis rs4332037 0.539 rs11764590 chr7:2032803 C/T cg23378565 chr7:2036160 MAD1L1 -0.5 -7.03 -0.36 1.17e-11 Bipolar disorder; CRC trans rs11818462 0.522 rs72821972 chr10:107167108 C/T cg13239252 chr12:85430145 TSPAN19;LRRIQ1 -0.62 -6.0 -0.31 5.07e-9 Colonoscopy-negative controls vs population controls; CRC cis rs12364620 1 rs12364620 chr11:68252123 T/G cg01657329 chr11:68192670 LRP5 -0.45 -6.42 -0.33 4.63e-10 Total body bone mineral density (age 0-15); CRC cis rs11764590 0.715 rs55770986 chr7:2087823 T/C cg23422044 chr7:1970798 MAD1L1 -0.49 -5.85 -0.31 1.16e-8 Neuroticism; CRC cis rs1005277 0.579 rs2472176 chr10:38382921 T/C cg25427524 chr10:38739819 LOC399744 -0.77 -13.64 -0.6 6.68e-34 Extrinsic epigenetic age acceleration; CRC cis rs2836950 0.565 rs2836931 chr21:40546569 T/G cg17971929 chr21:40555470 PSMG1 -0.6 -8.81 -0.44 7.55e-17 Menarche (age at onset); CRC cis rs3751196 0.708 rs55724382 chr12:104155075 T/C cg02344784 chr12:104178138 NT5DC3 0.66 6.21 0.32 1.63e-9 Sense of smell; CRC cis rs10504229 0.953 rs78089850 chr8:58171557 A/G cg02725872 chr8:58115012 NA -0.38 -6.31 -0.33 9.08e-10 Developmental language disorder (linguistic errors); CRC cis rs611744 0.647 rs1448151 chr8:109276283 C/A cg21045802 chr8:109455806 TTC35 0.43 6.83 0.35 4.07e-11 Dupuytren's disease; CRC cis rs1843834 0.929 rs4674934 chr2:225516468 A/T cg22455342 chr2:225449267 CUL3 -0.43 -5.9 -0.31 8.99e-9 IgE levels in asthmatics (D.p. specific); CRC cis rs826838 1.000 rs11168676 chr12:38977304 A/G cg13010199 chr12:38710504 ALG10B 0.44 5.79 0.3 1.65e-8 Heart rate; CRC cis rs1223397 0.651 rs2496146 chr6:13312474 A/G cg07912922 chr6:13274314 PHACTR1 0.38 6.0 0.31 5.21e-9 Blood pressure; CRC cis rs8180040 0.932 rs1531875 chr3:47452786 G/A cg10298567 chr3:47292165 KIF9 -0.35 -5.82 -0.31 1.36e-8 Colorectal cancer; CRC cis rs2032447 0.639 rs198810 chr6:26128618 A/G cg03517284 chr6:25882590 NA 0.43 5.8 0.3 1.59e-8 Intelligence (multi-trait analysis); CRC cis rs2991971 0.967 rs12743512 chr1:45954033 A/G cg24296786 chr1:45957014 TESK2 -0.53 -7.63 -0.39 2.56e-13 High light scatter reticulocyte count; CRC cis rs58688157 0.924 rs35865896 chr11:584591 A/G cg14433983 chr11:636460 DRD4 -0.42 -6.17 -0.32 2.01e-9 Systemic lupus erythematosus; CRC cis rs2153535 0.580 rs7453115 chr6:8447261 A/G cg07606381 chr6:8435919 SLC35B3 0.67 10.79 0.51 1.94e-23 Motion sickness; CRC cis rs10504229 0.683 rs2005392 chr8:58106896 T/C cg02725872 chr8:58115012 NA -0.66 -11.36 -0.53 1.85e-25 Developmental language disorder (linguistic errors); CRC cis rs11711311 1.000 rs6792447 chr3:113508335 T/C cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.52 -7.07 -0.36 9.16e-12 IgG glycosylation; CRC cis rs35306767 0.903 rs12254002 chr10:929133 A/G cg20503657 chr10:835505 NA -0.9 -11.41 -0.53 1.27e-25 Eosinophil percentage of granulocytes; CRC cis rs9427116 0.502 rs9427100 chr1:154583762 G/A cg17218026 chr1:154582156 ADAR 0.65 11.25 0.53 4.57e-25 Blood protein levels; CRC cis rs6598955 0.670 rs7531518 chr1:26539749 T/C cg04990556 chr1:26633338 UBXN11 -0.79 -13.29 -0.59 1.53e-32 Obesity-related traits; CRC cis rs6545883 0.540 rs11687956 chr2:61851342 T/C cg15711740 chr2:61764176 XPO1 0.42 5.67 0.3 3.07e-8 Tuberculosis; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg02002494 chr3:119013045 CDGAP 0.52 7.53 0.38 4.97e-13 Response to antipsychotic treatment; CRC trans rs7474896 0.887 rs12570864 chr10:37937293 T/C cg16724811 chr16:15130678 PDXDC1 -0.62 -6.01 -0.31 4.96e-9 Obesity (extreme); CRC cis rs7771547 0.573 rs544267 chr6:36398302 A/G cg07856975 chr6:36356162 ETV7 0.4 5.76 0.3 1.91e-8 Platelet distribution width; CRC cis rs3820068 0.705 rs11584209 chr1:15885041 G/T cg27534772 chr1:16042836 PLEKHM2 0.44 7.16 0.37 5.35e-12 Systolic blood pressure; CRC trans rs7267979 0.966 rs2424714 chr20:25418681 T/G cg17903999 chr18:56338584 MALT1 -0.42 -6.98 -0.36 1.6e-11 Liver enzyme levels (alkaline phosphatase); CRC cis rs7224737 0.956 rs8081900 chr17:40289875 G/A cg02228675 chr17:40259724 DHX58 -0.48 -6.78 -0.35 5.51e-11 Fibrinogen levels; CRC cis rs731174 0.840 rs525379 chr1:38151705 T/C cg06917450 chr1:38156652 C1orf109 -0.51 -7.18 -0.37 4.74e-12 Prostate cancer (SNP x SNP interaction); CRC cis rs7546094 1.000 rs7513716 chr1:113089320 A/T cg22162597 chr1:113214053 CAPZA1 0.43 5.93 0.31 7.67e-9 Platelet distribution width; CRC cis rs2645694 0.533 rs2645680 chr4:77820956 T/C cg18351406 chr4:77819688 ANKRD56 0.5 7.54 0.38 4.65e-13 Emphysema distribution in smoking; CRC cis rs9807989 0.507 rs3755266 chr2:103042712 G/A cg03938978 chr2:103052716 IL18RAP 0.59 10.1 0.49 4.49e-21 Asthma; CRC cis rs9394159 0.583 rs6457738 chr6:33617464 C/T cg14003231 chr6:33640908 ITPR3 -0.56 -9.28 -0.46 2.35e-18 Graves' disease; CRC cis rs7178572 0.568 rs3743478 chr15:77400388 T/C cg22256960 chr15:77711686 NA -0.62 -8.56 -0.43 4.31e-16 Type 2 diabetes; CRC cis rs2180341 0.814 rs6905553 chr6:127727407 A/G cg27446573 chr6:127587934 RNF146 0.69 9.42 0.46 8.11e-19 Breast cancer; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg05805736 chr6:42952517 PPP2R5D 0.43 6.11 0.32 2.89e-9 Intelligence (multi-trait analysis); CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg02577203 chr11:47869805 NUP160 -0.51 -6.17 -0.32 1.95e-9 Diisocyanate-induced asthma; CRC cis rs7605827 0.866 rs4668901 chr2:15521677 A/G cg19274914 chr2:15703543 NA 0.39 5.9 0.31 8.92e-9 Educational attainment (years of education); CRC cis rs6540559 0.611 rs926347 chr1:209965193 T/C cg25204440 chr1:209979598 IRF6 0.49 5.92 0.31 8.29e-9 Cleft lip with or without cleft palate; CRC cis rs67311347 0.868 rs10865895 chr3:40378677 C/T cg09455208 chr3:40491958 NA 0.44 8.77 0.44 1.01e-16 Renal cell carcinoma; CRC cis rs1355223 1.000 rs11604069 chr11:34764251 A/G cg11058730 chr11:34937778 PDHX;APIP -0.44 -6.2 -0.32 1.66e-9 Systemic lupus erythematosus and Systemic sclerosis; CRC cis rs7177699 0.557 rs7176187 chr15:79121373 A/G cg15571903 chr15:79123663 NA 0.3 5.99 0.31 5.5e-9 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; CRC cis rs9894429 0.683 rs112612275 chr17:79552604 C/A cg18240062 chr17:79603768 NPLOC4 -0.67 -11.85 -0.55 3.21e-27 Eye color traits; CRC cis rs1577917 1.000 rs12201735 chr6:86656939 C/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.51 -6.75 -0.35 6.74e-11 Response to antipsychotic treatment; CRC cis rs7619833 0.592 rs7615829 chr3:27252196 C/G cg02860705 chr3:27208620 NA 0.37 5.82 0.31 1.42e-8 Breast cancer; CRC cis rs2228479 0.850 rs17226512 chr16:89839976 T/C cg06656553 chr16:89960601 TCF25 -0.7 -5.97 -0.31 6.14e-9 Skin colour saturation; CRC cis rs77633900 0.614 rs279999 chr15:76945466 C/T cg21673338 chr15:77095150 SCAPER -0.73 -7.26 -0.37 2.89e-12 Non-glioblastoma glioma;Glioma; CRC cis rs9287719 0.967 rs728281 chr2:10750355 T/C cg00105475 chr2:10696890 NA 0.45 7.17 0.37 4.87e-12 Prostate cancer; CRC cis rs2985684 0.846 rs10150624 chr14:50051565 A/G cg23565292 chr14:50234668 KLHDC2 -0.44 -6.21 -0.32 1.57e-9 Carotid intima media thickness; CRC cis rs2836974 0.897 rs36113648 chr21:40555497 G/A cg17971929 chr21:40555470 PSMG1 0.87 13.1 0.59 7.35e-32 Cognitive function; CRC cis rs9326248 0.953 rs488962 chr11:117072525 C/T cg20608306 chr11:116969690 SIK3 -0.3 -5.78 -0.3 1.71e-8 Blood protein levels; CRC cis rs10504229 0.906 rs17805439 chr8:58172400 T/C cg02290350 chr8:58132656 NA -0.42 -5.96 -0.31 6.62e-9 Developmental language disorder (linguistic errors); CRC cis rs2797160 1.000 rs1739348 chr6:126014573 T/C cg05901451 chr6:126070800 HEY2 0.39 6.06 0.32 3.66e-9 Endometrial cancer; CRC cis rs62064224 0.554 rs9894877 chr17:30679517 T/A cg18200150 chr17:30822561 MYO1D 0.45 8.6 0.43 3.29e-16 Schizophrenia; CRC cis rs561341 0.824 rs1978115 chr17:30220776 A/C cg00745463 chr17:30367425 LRRC37B -0.75 -8.49 -0.42 7.36e-16 Hip circumference adjusted for BMI; CRC cis rs7726839 0.578 rs10080150 chr5:593160 C/T cg09021430 chr5:549028 NA 0.92 17.77 0.7 5.25e-50 Obesity-related traits; CRC cis rs875971 0.965 rs6971509 chr7:65714970 G/T cg18876405 chr7:65276391 NA -0.52 -8.74 -0.43 1.2e-16 Aortic root size; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg11969144 chr1:87797684 LMO4 0.37 6.26 0.33 1.2e-9 Liver disease severity in Alagille syndrome; CRC cis rs2228479 0.717 rs2074904 chr16:89811546 A/G cg06656553 chr16:89960601 TCF25 -0.69 -5.74 -0.3 2.15e-8 Skin colour saturation; CRC cis rs7666738 0.822 rs9992360 chr4:98937123 T/C cg17366294 chr4:99064904 C4orf37 0.43 7.32 0.37 1.95e-12 Colonoscopy-negative controls vs population controls; CRC cis rs9443645 0.901 rs6912683 chr6:79543492 C/A cg09184832 chr6:79620586 NA -0.51 -9.43 -0.46 7.73e-19 Intelligence (multi-trait analysis); CRC cis rs3796352 1.000 rs60942590 chr3:53016421 G/A cg07884673 chr3:53033167 SFMBT1 0.67 5.89 0.31 9.73e-9 Immune reponse to smallpox (secreted IL-2); CRC cis rs2404618 0.504 rs2906567 chr8:1494118 C/T cg13402656 chr8:1511478 DLGAP2 -0.71 -12.09 -0.55 4.36e-28 Lung cancer; CRC cis rs62064224 0.546 rs1018866 chr17:30829664 A/C cg01480708 chr17:30846118 MYO1D -0.38 -6.38 -0.33 6.03e-10 Schizophrenia; CRC cis rs4970988 0.640 rs7524734 chr1:150655686 C/T cg15448220 chr1:150897856 SETDB1 0.45 6.43 0.33 4.42e-10 Urate levels; CRC cis rs9814567 1.000 rs4955485 chr3:134295843 G/A cg06109529 chr3:134205091 CEP63;ANAPC13 -0.8 -11.7 -0.54 1.13e-26 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs853679 1.000 rs853678 chr6:28297313 T/A cg03623178 chr6:28175578 NA 0.64 6.81 0.35 4.77e-11 Depression; CRC trans rs2727020 0.688 rs11040338 chr11:49360601 A/G cg11707556 chr5:10655725 ANKRD33B 0.35 6.53 0.34 2.45e-10 Coronary artery disease; CRC cis rs802075 1.000 rs802075 chr6:49654166 A/G cg20364632 chr6:49636226 NA -0.35 -5.73 -0.3 2.27e-8 Bone mineral density (hip) and age at menarche; CRC cis rs7769051 1.000 rs7769051 chr6:133146796 G/T cg07930552 chr6:133119739 C6orf192 0.52 5.91 0.31 8.7e-9 Type 2 diabetes nephropathy; CRC cis rs919433 0.889 rs787995 chr2:198216853 T/G cg03934865 chr2:198174659 NA 0.36 5.82 0.31 1.37e-8 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC cis rs4481887 0.893 rs9651175 chr1:248446888 G/T cg00666640 chr1:248458726 OR2T12 0.54 9.7 0.47 1.01e-19 Common traits (Other); CRC cis rs3806843 0.966 rs3756341 chr5:140171194 C/T cg19875535 chr5:140030758 IK 0.6 9.8 0.48 4.77e-20 Depressive symptoms (multi-trait analysis); CRC trans rs11039798 0.588 rs11039855 chr11:48610091 A/G cg03929089 chr4:120376271 NA 0.66 7.06 0.36 1.02e-11 Axial length; CRC cis rs11628318 0.803 rs2277468 chr14:103024080 A/G cg08075719 chr14:103021372 NA -0.65 -8.48 -0.42 7.7e-16 Platelet count; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg15365320 chr11:17373302 DKFZp686O24166 0.44 6.2 0.32 1.69e-9 Anxiety disorder; CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg07580707 chr3:14220061 XPC;LSM3 0.4 6.36 0.33 6.66e-10 Obesity-related traits; CRC cis rs4566357 0.615 rs10174591 chr2:227913140 G/A cg11843606 chr2:227700838 RHBDD1 -0.44 -6.79 -0.35 5.1e-11 Coronary artery disease; CRC cis rs736408 0.608 rs4687657 chr3:52852538 G/T cg18404041 chr3:52824283 ITIH1 -0.4 -7.36 -0.38 1.48e-12 Bipolar disorder; CRC cis rs9311474 0.629 rs4282054 chr3:52566065 T/C cg01758942 chr3:52551074 STAB1 0.3 5.95 0.31 6.96e-9 Electroencephalogram traits; CRC cis rs2032447 0.966 rs7756117 chr6:26046565 A/G cg27635394 chr6:26043820 HIST1H2BB -0.38 -5.7 -0.3 2.61e-8 Intelligence (multi-trait analysis); CRC cis rs4908768 0.539 rs11121204 chr1:8654305 A/G cg20416874 chr1:8611966 RERE 0.45 6.02 0.31 4.77e-9 Neuroticism (multi-trait analysis);Subjective well-being (multi-trait analysis); CRC cis rs62064224 0.714 rs11657299 chr17:30634951 G/A cg25809561 chr17:30822961 MYO1D 0.52 9.52 0.46 3.97e-19 Schizophrenia; CRC cis rs2976388 0.565 rs2572905 chr8:143797104 C/T cg15511327 chr8:143859410 LYNX1 0.4 7.25 0.37 2.95e-12 Urinary tract infection frequency; CRC cis rs763014 0.966 rs4984677 chr16:671682 A/G cg03804128 chr16:635623 NA 0.3 6.93 0.36 2.25e-11 Height; CRC cis rs898097 0.578 rs9906163 chr17:80908174 T/C cg19046167 chr17:80928561 B3GNTL1 0.47 8.04 0.41 1.66e-14 Breast cancer; CRC cis rs4728302 0.869 rs6966403 chr7:133614421 A/C cg10665199 chr7:133106180 EXOC4 -0.4 -6.0 -0.31 5.18e-9 Intelligence;Intelligence (multi-trait analysis); CRC cis rs9291683 0.546 rs4529049 chr4:10045389 C/T cg00071950 chr4:10020882 SLC2A9 0.63 11.32 0.53 2.63e-25 Bone mineral density; CRC cis rs17666538 0.792 rs1703912 chr8:600643 A/G cg23958373 chr8:599963 NA 0.93 8.88 0.44 4.4e-17 IgG glycosylation; CRC cis rs7940866 0.834 rs1594821 chr11:130835883 C/T cg12179176 chr11:130786555 SNX19 0.59 8.77 0.44 9.48e-17 Schizophrenia; CRC cis rs10870270 1.000 rs10781564 chr10:133757922 A/G cg08754478 chr10:133766260 PPP2R2D -0.66 -9.46 -0.46 6.05e-19 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; CRC cis rs3849570 0.615 rs1851918 chr3:81980557 C/T cg07356753 chr3:81810745 GBE1 -0.48 -6.62 -0.34 1.46e-10 Waist circumference;Body mass index; CRC cis rs1475911 1.000 rs12482477 chr21:43517233 T/A cg14562523 chr21:43528734 C21orf128;UMODL1 -0.51 -6.96 -0.36 1.83e-11 IgG glycosylation; CRC cis rs698833 0.892 rs1067322 chr2:44630107 C/T cg04920474 chr2:44395004 PPM1B 0.39 5.65 0.3 3.51e-8 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; CRC cis rs3749237 0.964 rs35210174 chr3:49812606 C/T cg24308560 chr3:49941425 MST1R -0.43 -6.18 -0.32 1.85e-9 Resting heart rate; CRC trans rs7746199 0.736 rs17693963 chr6:27710165 A/C cg16898833 chr6:26189333 HIST1H4D 1.0 7.2 0.37 4.15e-12 Gait speed in old age;Autism spectrum disorder or schizophrenia; CRC cis rs6456156 0.792 rs4710181 chr6:167513998 T/C cg07513332 chr6:167530253 CCR6 0.38 6.25 0.33 1.27e-9 Primary biliary cholangitis; CRC cis rs6088813 1.000 rs6142374 chr20:33985568 C/T cg14752227 chr20:34000481 UQCC -0.37 -5.72 -0.3 2.33e-8 Height; CRC trans rs10506458 0.915 rs1009540 chr12:63414872 C/A cg22491629 chr6:157744540 C6orf35 -0.76 -9.02 -0.45 1.57e-17 Hemostatic factors and hematological phenotypes; CRC trans rs2228479 0.850 rs62054610 chr16:89816920 G/A cg24644049 chr4:85504048 CDS1 0.9 7.46 0.38 7.69e-13 Skin colour saturation; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg06456258 chr22:39898429 SMCR7L 0.45 6.29 0.33 1.02e-9 Anxiety disorder; CRC cis rs936229 0.656 rs12898397 chr15:75130093 T/C cg14664628 chr15:75095509 CSK -0.68 -11.18 -0.52 8.14e-25 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); CRC cis rs644799 0.896 rs4430471 chr11:95646774 G/A cg25622487 chr11:95524042 FAM76B;CEP57 0.72 10.67 0.51 4.93e-23 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs2839186 0.721 rs3788252 chr21:47661235 C/T cg05896524 chr21:47604654 C21orf56 0.51 7.84 0.4 6.25e-14 Testicular germ cell tumor; CRC cis rs3018066 0.777 rs11725254 chr4:106943155 G/C cg01869342 chr4:106983673 TBCK 0.44 6.04 0.32 4.23e-9 Cancer; CRC cis rs6831352 0.703 rs3133152 chr4:100031721 C/G cg13256891 chr4:100009986 ADH5 0.56 7.89 0.4 4.44e-14 Alcohol dependence; CRC trans rs1656966 1.000 rs1656966 chr3:186466252 C/T cg14810013 chr4:66535412 EPHA5 0.29 6.36 0.33 6.93e-10 Myopia (pathological); CRC cis rs651907 0.535 rs11717638 chr3:101505468 A/G cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.58 7.75 0.39 1.19e-13 Colorectal cancer; CRC cis rs11711311 1.000 rs62268169 chr3:113493860 G/A cg15478005 chr3:113465772 ATP6V1A;NAA50 0.44 6.04 0.32 4.24e-9 IgG glycosylation; CRC cis rs1153858 1.000 rs1719247 chr15:45620985 C/T cg10760299 chr15:45669010 GATM 0.48 7.63 0.39 2.56e-13 Homoarginine levels; CRC cis rs2645694 0.626 rs2703122 chr4:77821418 A/C cg18351406 chr4:77819688 ANKRD56 0.5 7.53 0.38 5e-13 Emphysema distribution in smoking; CRC cis rs10071761 0.513 rs4957277 chr5:40361734 A/G cg09067459 chr5:40385259 NA -0.53 -7.11 -0.37 7.18e-12 Selective IgA deficiency; CRC cis rs1577917 0.696 rs2842617 chr6:86309698 C/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.57 -8.03 -0.4 1.74e-14 Response to antipsychotic treatment; CRC cis rs73206853 0.697 rs56084592 chr12:110577910 T/A cg12870014 chr12:110450643 ANKRD13A 0.82 10.31 0.49 8.97e-22 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC cis rs4481887 0.893 rs7528645 chr1:248427291 T/A cg00666640 chr1:248458726 OR2T12 0.51 8.99 0.44 1.98e-17 Common traits (Other); CRC cis rs1552244 1.000 rs6793396 chr3:10110927 T/C cg13047869 chr3:10149882 C3orf24 0.57 7.8 0.4 8.27e-14 Alzheimer's disease; CRC trans rs3749237 0.964 rs35210174 chr3:49812606 C/T cg21659725 chr3:3221576 CRBN 0.56 7.88 0.4 4.96e-14 Resting heart rate; CRC cis rs2836974 0.897 rs8128102 chr21:40606414 G/A cg11644478 chr21:40555479 PSMG1 0.8 12.06 0.55 5.56e-28 Cognitive function; CRC cis rs9359856 0.564 rs56281344 chr6:90445393 T/C cg13799429 chr6:90582589 CASP8AP2 -0.75 -7.58 -0.39 3.44e-13 Bipolar disorder; CRC cis rs13333054 1.000 rs13333054 chr16:86011033 C/T cg08215318 chr16:86016387 NA 0.81 11.69 0.54 1.18e-26 Multiple sclerosis; CRC cis rs9914544 1.000 rs28436199 chr17:18751730 C/T cg26378065 chr17:18585709 ZNF286B 0.43 5.88 0.31 1.02e-8 Educational attainment (years of education); CRC cis rs9911578 1.000 rs12453459 chr17:56624291 C/T cg12560992 chr17:57184187 TRIM37 -0.91 -17.13 -0.69 1.81e-47 Intelligence (multi-trait analysis); CRC cis rs10504229 1.000 rs9650139 chr8:58190508 G/T cg02725872 chr8:58115012 NA -0.38 -6.42 -0.33 4.72e-10 Developmental language disorder (linguistic errors); CRC cis rs10540 1.000 rs35811812 chr11:498442 G/A cg11503833 chr11:492997 NA 0.54 6.09 0.32 3.13e-9 Body mass index; CRC cis rs6942756 0.956 rs13235668 chr7:128879710 A/G cg02491457 chr7:128862824 NA -0.75 -10.28 -0.49 1.09e-21 White matter hyperintensity burden; CRC trans rs7615952 0.866 rs1976459 chr3:125647486 A/T cg21747405 chr11:67723411 NA -0.44 -6.29 -0.33 9.96e-10 Blood pressure (smoking interaction); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg17864040 chr1:78148524 ZZZ3 0.43 6.09 0.32 3.14e-9 Response to antipsychotic treatment; CRC cis rs344364 0.511 rs1742468 chr16:1950243 C/G cg09830162 chr16:1889614 FAHD1;C16orf73 -0.77 -9.36 -0.46 1.32e-18 Glomerular filtration rate in chronic kidney disease; CRC cis rs7809950 1.000 rs2237673 chr7:107131580 T/C cg23024343 chr7:107201750 COG5 -0.61 -8.69 -0.43 1.78e-16 Coronary artery disease; CRC cis rs782590 0.537 rs7575170 chr2:55886780 C/T cg18811423 chr2:55921094 PNPT1 -0.67 -9.17 -0.45 5.2e-18 Metabolic syndrome; CRC cis rs3736485 0.966 rs8042289 chr15:51899884 A/G cg08986416 chr15:51914746 DMXL2 -0.45 -6.49 -0.34 3.08e-10 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs2549003 1.000 rs2070723 chr5:131823187 A/G cg21138405 chr5:131827807 IRF1 0.56 10.95 0.52 5.37e-24 Asthma (sex interaction); CRC cis rs959260 0.623 rs4542691 chr17:73326965 T/C cg14668889 chr17:73230827 NUP85 -0.51 -7.44 -0.38 8.84e-13 Systemic lupus erythematosus; CRC cis rs7731657 0.537 rs4705917 chr5:130206326 A/G cg08523029 chr5:130500466 HINT1 -0.42 -5.7 -0.3 2.67e-8 Fasting plasma glucose; CRC cis rs67311347 0.568 rs57287242 chr3:40335538 T/C cg09455208 chr3:40491958 NA 0.31 6.31 0.33 8.76e-10 Renal cell carcinoma; CRC cis rs561341 0.941 rs112569713 chr17:30271738 C/T cg23018236 chr17:30244563 NA -0.57 -7.48 -0.38 6.78e-13 Hip circumference adjusted for BMI; CRC cis rs6963495 0.799 rs73190201 chr7:105165891 A/C cg02135003 chr7:105160482 PUS7 -0.91 -12.41 -0.56 2.87e-29 Bipolar disorder (body mass index interaction); CRC cis rs11602339 1 rs11602339 chr11:47761471 C/T cg05585544 chr11:47624801 NA -0.62 -10.84 -0.51 1.26e-23 Body mass index; CRC cis rs6088813 0.890 rs6088817 chr20:33984976 T/C cg14752227 chr20:34000481 UQCC -0.37 -5.72 -0.3 2.33e-8 Height; CRC cis rs1862618 0.853 rs252915 chr5:56121754 C/T cg03609598 chr5:56110824 MAP3K1 0.78 9.82 0.48 4.08e-20 Initial pursuit acceleration; CRC cis rs2991971 1.000 rs9147 chr1:46016687 T/C cg24296786 chr1:45957014 TESK2 0.51 7.2 0.37 4.11e-12 High light scatter reticulocyte count; CRC cis rs9611565 0.546 rs5758426 chr22:42098763 T/G cg03806693 chr22:41940476 POLR3H 0.69 9.48 0.46 5.06e-19 Vitiligo; CRC cis rs9399135 0.967 rs45544135 chr6:135324051 T/C cg24558204 chr6:135376177 HBS1L 0.51 8.13 0.41 9e-15 Red blood cell count; CRC cis rs763121 0.819 rs138700 chr22:39129999 A/G cg06544989 chr22:39130855 UNC84B 0.46 7.15 0.37 5.49e-12 Menopause (age at onset); CRC cis rs6424115 0.830 rs2229584 chr1:24200969 T/C cg15997130 chr1:24165203 NA 0.73 10.74 0.51 2.79e-23 Immature fraction of reticulocytes; CRC cis rs1552244 0.572 rs6783705 chr3:10164783 A/G cg16606324 chr3:10149918 C3orf24 0.66 7.74 0.39 1.19e-13 Alzheimer's disease; CRC cis rs7666738 0.830 rs7674095 chr4:99048158 T/A cg05340658 chr4:99064831 C4orf37 0.6 9.35 0.46 1.4e-18 Colonoscopy-negative controls vs population controls; CRC cis rs4481887 0.927 rs4564179 chr1:248472422 T/C cg13385794 chr1:248469461 NA 0.38 6.75 0.35 6.84e-11 Common traits (Other); CRC cis rs9443645 0.901 rs2152951 chr6:79762172 A/G cg11833968 chr6:79620685 NA 0.36 6.27 0.33 1.11e-9 Intelligence (multi-trait analysis); CRC cis rs4253772 0.591 rs7286155 chr22:46714735 A/G cg03482458 chr22:46692211 CN5H6.4;GTSE1 0.5 5.82 0.31 1.4e-8 LDL cholesterol;Cholesterol, total; CRC cis rs270601 0.633 rs4535443 chr5:131572561 A/G cg04518342 chr5:131593106 PDLIM4 0.57 9.82 0.48 3.86e-20 Acylcarnitine levels; CRC trans rs8002861 0.875 rs12428432 chr13:44464043 A/G cg12856521 chr11:46389249 DGKZ -0.42 -6.64 -0.34 1.3100000000000001e-10 Leprosy; CRC cis rs7680126 0.562 rs4698036 chr4:10331294 T/G cg00071950 chr4:10020882 SLC2A9 -0.48 -6.76 -0.35 6.34e-11 Urate levels in lean individuals;Urate levels in overweight individuals;Urate levels in obese individuals; CRC cis rs7917772 0.536 rs11191361 chr10:104411958 C/T cg11453585 chr10:104263688 ACTR1A;SUFU 0.88 13.74 0.6 2.92e-34 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC cis rs8177253 0.930 rs12595 chr3:133496553 T/C cg08048268 chr3:133502702 NA -0.4 -7.44 -0.38 9e-13 Iron status biomarkers; CRC cis rs1799949 0.965 rs8176087 chr17:41270666 C/A cg05368731 chr17:41323189 NBR1 0.65 9.55 0.47 3.16e-19 Menopause (age at onset); CRC trans rs7618501 0.633 rs35065728 chr3:50009176 T/C cg21665057 chr3:196295764 WDR53;FBXO45 0.57 9.0 0.44 1.84e-17 Intelligence (multi-trait analysis); CRC cis rs7666738 0.830 rs17027102 chr4:98919221 A/G cg17366294 chr4:99064904 C4orf37 -0.44 -7.37 -0.38 1.39e-12 Colonoscopy-negative controls vs population controls; CRC cis rs7605827 0.930 rs10189403 chr2:15635664 T/A cg19274914 chr2:15703543 NA 0.4 6.09 0.32 3.22e-9 Educational attainment (years of education); CRC trans rs9858542 1.000 rs9858542 chr3:49701983 A/G cg21665057 chr3:196295764 WDR53;FBXO45 0.65 8.55 0.43 4.55e-16 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs796364 0.906 rs281766 chr2:200820505 T/G cg25936922 chr2:200820526 C2orf60;C2orf47 0.72 7.62 0.39 2.82e-13 Schizophrenia; CRC cis rs853679 0.607 rs33932084 chr6:28268824 A/G cg26958806 chr6:27640298 NA 0.93 6.61 0.34 1.55e-10 Depression; CRC cis rs7605827 0.930 rs1986279 chr2:15617390 G/A cg19274914 chr2:15703543 NA 0.39 5.9 0.31 8.83e-9 Educational attainment (years of education); CRC cis rs4975616 1.000 rs4975616 chr5:1315660 G/A cg26373071 chr5:1325741 CLPTM1L -0.5 -8.59 -0.43 3.61e-16 Lung cancer; CRC cis rs2050392 0.858 rs2250569 chr10:30698914 G/C cg18806716 chr10:30721971 MAP3K8 -0.46 -7.15 -0.37 5.52e-12 Inflammatory bowel disease; CRC cis rs9914988 0.943 rs4795457 chr17:27087929 C/T cg07195577 chr17:27052828 TLCD1 0.4 5.66 0.3 3.36e-8 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs6461049 0.765 rs4719432 chr7:2140330 A/G cg22963979 chr7:1858916 MAD1L1 -0.49 -7.77 -0.39 9.77e-14 Schizophrenia; CRC cis rs6502050 0.835 rs4789724 chr17:80150546 G/A cg22110888 chr17:80059540 CCDC57 0.4 6.32 0.33 8.64e-10 Life satisfaction; CRC cis rs4642101 0.535 rs55692304 chr3:12840057 C/T cg24848339 chr3:12840334 CAND2 0.35 6.66 0.34 1.16e-10 QRS complex (12-leadsum); CRC cis rs4730250 0.707 rs3729877 chr7:106787065 T/G cg02696742 chr7:106810147 HBP1 0.57 6.56 0.34 2.11e-10 Osteoarthritis; CRC cis rs1707322 1.000 rs1707303 chr1:46598273 A/C cg03146154 chr1:46216737 IPP -0.54 -7.23 -0.37 3.4e-12 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs501120 1.000 rs559580 chr10:44752078 C/T cg09554077 chr10:44749378 NA -0.84 -11.48 -0.53 6.8e-26 Coronary artery disease;Coronary heart disease; CRC cis rs1728785 0.901 rs7194664 chr16:68643313 T/C cg02972257 chr16:68554789 NA -0.54 -6.69 -0.35 9.59e-11 Ulcerative colitis; CRC cis rs789859 1.000 rs789859 chr3:194405888 G/T cg02072170 chr3:194406190 FAM43A 0.42 7.22 0.37 3.71e-12 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; CRC cis rs853679 0.607 rs201002 chr6:27808192 A/G cg15845792 chr6:28175446 NA 0.7 6.22 0.32 1.51e-9 Depression; CRC cis rs9911578 1.000 rs9898916 chr17:57048660 C/T cg12560992 chr17:57184187 TRIM37 0.92 17.11 0.69 2.18e-47 Intelligence (multi-trait analysis); CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg11310629 chr13:45991975 SLC25A30 0.48 6.31 0.33 8.78e-10 Thyroid stimulating hormone; CRC cis rs7945718 0.967 rs10831906 chr11:12783042 C/T cg25843174 chr11:12811716 TEAD1 0.48 9.18 0.45 5.01e-18 Educational attainment (years of education); CRC cis rs7945705 0.776 rs11042069 chr11:8817315 G/A cg21881798 chr11:8931708 C11orf17;ST5 0.49 7.2 0.37 4.04e-12 Hemoglobin concentration; CRC trans rs57221529 0.766 rs72703064 chr5:587825 T/C cg25482853 chr8:67687455 SGK3 1.24 14.83 0.63 1.93e-38 Lung disease severity in cystic fibrosis; CRC trans rs6500957 0.920 rs17648524 chr16:7459683 C/G cg08245425 chr17:34957834 MRM1 0.45 6.65 0.34 1.2e-10 Spherical equivalent (joint analysis main effects and education interaction); CRC cis rs9611519 0.929 rs9611509 chr22:41565827 A/G cg03806693 chr22:41940476 POLR3H -0.56 -7.17 -0.37 4.95e-12 Neuroticism; CRC cis rs9916302 0.784 rs4795361 chr17:37573446 G/A cg07936489 chr17:37558343 FBXL20 -0.79 -12.05 -0.55 5.82e-28 Glomerular filtration rate (creatinine); CRC cis rs11792861 0.781 rs838835 chr9:111758590 A/G cg05043794 chr9:111880884 C9orf5 0.33 6.12 0.32 2.7e-9 Menarche (age at onset); CRC cis rs6534441 0.697 rs75752108 chr4:125428768 A/G cg21609808 chr4:125404261 NA 0.45 6.32 0.33 8.42e-10 Major depressive disorder; CRC cis rs1185460 0.967 rs1784459 chr11:118938388 C/A cg23280166 chr11:118938394 VPS11 0.44 6.71 0.35 8.71e-11 Coronary artery disease; CRC cis rs13108904 0.517 rs13134568 chr4:1334289 G/A cg00684032 chr4:1343700 KIAA1530 0.59 8.26 0.41 3.54e-15 Obesity-related traits; CRC cis rs10504229 0.683 rs6984765 chr8:58127124 T/C cg24829409 chr8:58192753 C8orf71 -0.55 -8.03 -0.4 1.71e-14 Developmental language disorder (linguistic errors); CRC cis rs208520 0.690 rs6929762 chr6:66709277 C/T cg07460842 chr6:66804631 NA 1.04 14.64 0.63 1.04e-37 Exhaled nitric oxide output; CRC cis rs2295359 0.892 rs11209005 chr1:67618678 A/G cg17031739 chr1:67600172 NA 0.45 7.23 0.37 3.38e-12 Psoriasis; CRC cis rs10256972 0.621 rs2280725 chr7:1087426 G/T cg18402987 chr7:1209562 NA 0.39 5.83 0.31 1.31e-8 Longevity;Endometriosis; CRC cis rs4268898 0.662 rs2303291 chr2:24431184 C/T cg06627628 chr2:24431161 ITSN2 -0.86 -11.63 -0.54 1.94e-26 Asthma; CRC cis rs2274273 0.744 rs8011808 chr14:55823344 A/T cg23234261 chr14:55582407 NA -0.3 -5.98 -0.31 5.76e-9 Protein biomarker; CRC cis rs2153535 0.580 rs1932276 chr6:8442593 G/A cg07606381 chr6:8435919 SLC35B3 0.68 10.86 0.51 1.08e-23 Motion sickness; CRC cis rs2404602 0.646 rs3764245 chr15:77223176 G/C cg03037974 chr15:76606532 NA 0.56 8.23 0.41 4.37e-15 Blood metabolite levels; CRC cis rs4665809 0.652 rs6727974 chr2:26524639 A/G cg04944784 chr2:26401820 FAM59B 0.57 7.45 0.38 8.18e-13 Gut microbiome composition (summer); CRC cis rs10751667 0.666 rs7950967 chr11:955638 G/A cg23136738 chr11:925521 AP2A2 -0.42 -7.05 -0.36 1.03e-11 Alzheimer's disease (late onset); CRC cis rs6500602 0.893 rs6500598 chr16:4470964 G/T cg08645402 chr16:4508243 NA 0.56 8.18 0.41 6.37e-15 Schizophrenia; CRC cis rs11190604 1.000 rs7079756 chr10:102302105 G/A cg16342193 chr10:102329863 NA -0.34 -5.82 -0.31 1.37e-8 Palmitoleic acid (16:1n-7) levels; CRC cis rs10504229 1.000 rs114312649 chr8:58182539 C/G cg02725872 chr8:58115012 NA -0.38 -6.43 -0.33 4.44e-10 Developmental language disorder (linguistic errors); CRC cis rs2223471 0.870 rs2817422 chr6:50750240 G/C cg03432817 chr6:50765336 NA 0.37 5.92 0.31 8.1e-9 Subcutaneous adipose tissue; CRC cis rs1401999 1.000 rs13317532 chr3:183641669 G/C cg01324343 chr3:183735012 ABCC5 0.81 14.7 0.63 6.14e-38 Anterior chamber depth; CRC cis rs8031584 0.872 rs11634761 chr15:31243173 A/C cg08109568 chr15:31115862 NA -0.55 -8.77 -0.44 9.81e-17 Huntington's disease progression; CRC cis rs11030122 0.673 rs66596383 chr11:3979745 C/T cg18678763 chr11:4115507 RRM1 -0.48 -8.01 -0.4 1.94e-14 Mean platelet volume;Platelet distribution width; CRC trans rs16957091 0.528 rs34920950 chr15:43109479 T/A cg07673103 chr8:74277181 NA 0.56 6.12 0.32 2.74e-9 MGMT methylation in smokers; CRC cis rs11190604 1.000 rs10883499 chr10:102232188 T/A cg07080220 chr10:102295463 HIF1AN 0.47 5.71 0.3 2.59e-8 Palmitoleic acid (16:1n-7) levels; CRC cis rs3785574 0.924 rs2584641 chr17:61862889 A/G cg06601766 chr17:61851465 DDX42;CCDC47 0.6 8.66 0.43 2.12e-16 Height; CRC cis rs804292 1.000 rs804292 chr8:11643915 C/T cg26752888 chr8:11627280 NEIL2 -0.64 -8.17 -0.41 6.86e-15 Alcohol dependence;Nicotine use; CRC cis rs2281845 0.507 rs12025414 chr1:201100496 A/G cg24849736 chr1:201084428 NA 0.46 6.05 0.32 3.87e-9 Permanent tooth development; CRC cis rs644799 0.965 rs607039 chr11:95547086 G/A cg03916912 chr11:95522834 CEP57;FAM76B 0.95 18.15 0.71 1.71e-51 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs4689592 0.513 rs3857178 chr4:7066516 G/A cg06697600 chr4:7070879 GRPEL1 -0.5 -7.36 -0.38 1.48e-12 Monocyte percentage of white cells; CRC cis rs6840360 0.615 rs72728173 chr4:152469373 C/T cg09659197 chr4:152720779 NA 0.31 5.66 0.3 3.25e-8 Intelligence (multi-trait analysis); CRC cis rs4889855 0.530 rs8079792 chr17:78609394 A/G cg16591659 chr17:78472290 NA -0.43 -6.3 -0.33 9.56e-10 Fractional excretion of uric acid; CRC cis rs9902453 0.709 rs6505162 chr17:28444183 A/C cg26525008 chr17:28256777 EFCAB5;SSH2 0.58 8.89 0.44 4.14e-17 Coffee consumption (cups per day); CRC cis rs7615952 0.576 rs4646763 chr3:125822129 G/A cg15145296 chr3:125709740 NA -0.57 -6.72 -0.35 8.25e-11 Blood pressure (smoking interaction); CRC cis rs9291683 0.530 rs882223 chr4:9981625 A/C cg11266682 chr4:10021025 SLC2A9 0.5 10.34 0.5 6.86e-22 Bone mineral density; CRC cis rs2797160 1.000 rs1739376 chr6:126012084 C/G cg05901451 chr6:126070800 HEY2 0.38 5.95 0.31 6.74e-9 Endometrial cancer; CRC cis rs9462027 0.628 rs9348950 chr6:34673678 G/A cg07306190 chr6:34760872 UHRF1BP1 0.35 6.28 0.33 1.09e-9 Systemic lupus erythematosus; CRC cis rs9911578 0.967 rs4132925 chr17:56938016 C/G cg12560992 chr17:57184187 TRIM37 -0.93 -17.12 -0.69 1.91e-47 Intelligence (multi-trait analysis); CRC cis rs2046867 0.818 rs17010215 chr3:72886965 A/G cg25664220 chr3:72788482 NA -0.47 -6.69 -0.35 9.59e-11 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; CRC cis rs2040771 0.804 rs1091013 chr22:19248587 C/T cg02655711 chr22:19163373 SLC25A1 0.5 8.1 0.41 1.09e-14 Metabolite levels (small molecules and protein measures); CRC cis rs9311676 0.632 rs6777066 chr3:58361603 T/C cg06643156 chr3:58380774 PXK 0.43 6.73 0.35 7.6e-11 Systemic lupus erythematosus; CRC cis rs10504229 0.683 rs11774585 chr8:58132685 G/A cg02725872 chr8:58115012 NA -0.64 -11.55 -0.54 3.85e-26 Developmental language disorder (linguistic errors); CRC cis rs9359856 0.956 rs6934804 chr6:90316020 A/G cg13799429 chr6:90582589 CASP8AP2 0.45 6.37 0.33 6.31e-10 Bipolar disorder; CRC cis rs2795502 0.564 rs72777192 chr10:43436778 G/A cg08461752 chr10:43522343 NA -0.63 -5.9 -0.31 9.27e-9 Blood protein levels; CRC cis rs7100689 0.784 rs7082705 chr10:82170856 C/T cg00277334 chr10:82204260 NA 0.44 5.75 0.3 2.04e-8 Post bronchodilator FEV1; CRC cis rs4474465 0.790 rs10751293 chr11:78250956 A/T cg27205649 chr11:78285834 NARS2 0.53 6.93 0.36 2.22e-11 Alzheimer's disease (survival time); CRC cis rs34172651 0.917 rs6497756 chr16:24798291 G/T cg00339695 chr16:24857497 SLC5A11 0.26 6.01 0.31 5.01e-9 Intelligence (multi-trait analysis); CRC trans rs7615952 0.546 rs11718647 chr3:125352022 G/A cg21747405 chr11:67723411 NA -0.49 -6.42 -0.33 4.84e-10 Blood pressure (smoking interaction); CRC trans rs2303319 0.504 rs62189048 chr2:162613494 G/C cg22988483 chr14:93581567 ITPK1 -0.66 -6.07 -0.32 3.52e-9 Cognitive function; CRC cis rs7705042 0.761 rs10062349 chr5:141509597 G/A cg07392085 chr5:141489673 NDFIP1 0.46 7.24 0.37 3.17e-12 Asthma; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg10659886 chr19:58629719 ZSCAN18 0.23 6.7 0.35 9.19e-11 Liver disease severity in Alagille syndrome; CRC trans rs2303319 0.504 rs55638078 chr2:162524997 T/C cg18122310 chr12:50236657 BCDIN3D -0.73 -6.13 -0.32 2.58e-9 Cognitive function; CRC cis rs595982 0.559 rs73061643 chr19:49368151 A/G cg21252483 chr19:49399788 TULP2 -0.36 -5.93 -0.31 7.76e-9 Red cell distribution width; CRC cis rs9303401 0.614 rs66480139 chr17:57101538 G/A cg10487724 chr17:56770010 TEX14;RAD51C 0.71 8.95 0.44 2.66e-17 Cognitive test performance; CRC cis rs2842992 0.789 rs9365093 chr6:160175819 C/G cg16489826 chr6:160211363 TCP1;MRPL18 0.47 5.98 0.31 5.97e-9 Age-related macular degeneration (geographic atrophy); CRC cis rs4750440 0.671 rs1809305 chr10:14026780 G/A cg00551146 chr10:14014579 FRMD4A 0.4 6.35 0.33 7.14e-10 Adiponectin levels; CRC cis rs13315871 1.000 rs9860970 chr3:58353781 C/T cg20936604 chr3:58311152 NA -0.75 -6.89 -0.35 2.89e-11 Cholesterol, total; CRC cis rs875971 0.545 rs4718348 chr7:65906576 A/G cg18876405 chr7:65276391 NA 0.47 6.47 0.34 3.62e-10 Aortic root size; CRC cis rs9532580 0.778 rs34373380 chr13:41244217 T/A cg21288729 chr13:41239152 FOXO1 0.5 7.6 0.39 3.04e-13 Mean corpuscular hemoglobin; CRC cis rs57221529 0.766 rs28563961 chr5:554498 C/G cg14541582 chr5:601475 NA -0.33 -6.35 -0.33 7.09e-10 Lung disease severity in cystic fibrosis; CRC cis rs28829049 0.597 rs1009806 chr1:19500551 T/C cg13387374 chr1:19411106 UBR4 0.41 6.06 0.32 3.81e-9 QRS duration in Tripanosoma cruzi seropositivity; CRC cis rs929354 0.772 rs2051876 chr7:157009037 A/G cg05182265 chr7:156933206 UBE3C 0.75 14.32 0.62 1.76e-36 Body mass index; CRC trans rs3733585 0.673 rs4292333 chr4:9953871 G/A cg26043149 chr18:55253948 FECH -0.5 -7.71 -0.39 1.51e-13 Cleft plate (environmental tobacco smoke interaction); CRC cis rs7786808 0.707 rs10247026 chr7:158230595 C/T cg17401720 chr7:158221031 PTPRN2 0.46 7.56 0.38 3.95e-13 Obesity-related traits; CRC cis rs9527 0.590 rs1475642 chr10:104546183 C/T cg23093090 chr10:104574429 C10orf26 0.44 5.86 0.31 1.13e-8 Arsenic metabolism; CRC cis rs2842992 0.789 rs4276525 chr6:160193612 G/A cg16489826 chr6:160211363 TCP1;MRPL18 0.49 6.29 0.33 1.02e-9 Age-related macular degeneration (geographic atrophy); CRC cis rs7613875 0.578 rs4688753 chr3:50074773 A/G cg24110177 chr3:50126178 RBM5 0.58 9.13 0.45 6.99e-18 Body mass index; CRC cis rs2243480 1.000 rs1039664 chr7:65449716 T/G cg12463550 chr7:65579703 CRCP 0.64 6.1 0.32 3.01e-9 Diabetic kidney disease; CRC cis rs7917772 0.502 rs10748827 chr10:104368336 G/T cg22532475 chr10:104410764 TRIM8 -0.36 -6.51 -0.34 2.82e-10 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC trans rs6598955 0.671 rs10902727 chr1:26597781 C/T cg07461501 chr17:79650226 HGS;ARL16 -0.52 -6.19 -0.32 1.77e-9 Obesity-related traits; CRC cis rs55794721 0.509 rs12027110 chr1:25775682 A/T cg27572855 chr1:25598939 RHD 0.37 6.58 0.34 1.86e-10 Plateletcrit;Mean corpuscular volume; CRC cis rs10883723 0.810 rs1409311 chr10:104282160 G/A cg22532475 chr10:104410764 TRIM8 -0.36 -6.62 -0.34 1.45e-10 Allergic disease (asthma, hay fever or eczema); CRC trans rs6951245 0.938 rs78351779 chr7:1097023 G/C cg13565492 chr6:43139072 SRF -0.71 -7.38 -0.38 1.32e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs4838594 0.563 rs730509 chr10:49679153 C/A cg17291251 chr10:49678358 ARHGAP22 0.44 7.02 0.36 1.29e-11 Daytime sleep phenotypes; CRC cis rs12594515 1.000 rs12594515 chr15:45985071 C/G cg22117107 chr15:45993392 NA 0.44 8.82 0.44 6.78e-17 Waist circumference;Weight; CRC cis rs6424115 0.830 rs6672157 chr1:24198840 C/G cg15997130 chr1:24165203 NA 0.71 10.46 0.5 2.79e-22 Immature fraction of reticulocytes; CRC cis rs997295 0.570 rs28730805 chr15:67879418 G/A cg24247231 chr15:67904302 MAP2K5 -0.33 -5.75 -0.3 2e-8 Motion sickness; CRC cis rs9488822 0.636 rs12524932 chr6:116330266 G/A cg26893134 chr6:116381904 FRK 0.26 7.6 0.39 3.02e-13 Cholesterol, total;LDL cholesterol; CRC cis rs748404 0.676 rs4401024 chr15:43650335 C/T cg02155558 chr15:43621948 ADAL;LCMT2 0.53 7.76 0.39 1.08e-13 Lung cancer; CRC cis rs13064411 0.696 rs6768648 chr3:113234141 C/G cg18753928 chr3:113234510 CCDC52 -0.68 -10.39 -0.5 4.52e-22 Response to simvastatin treatment (PCSK9 protein level change); CRC trans rs61931739 0.534 rs4539411 chr12:34014807 T/C cg26384229 chr12:38710491 ALG10B 0.52 7.07 0.36 9.2e-12 Morning vs. evening chronotype; CRC cis rs9926296 0.568 rs7203907 chr16:89833774 C/G cg27121462 chr16:89883253 FANCA 0.57 9.04 0.45 1.41e-17 Vitiligo; CRC cis rs7618501 1.000 rs2271961 chr3:49878113 C/T cg24308560 chr3:49941425 MST1R 0.45 7.14 0.37 6.01e-12 Intelligence (multi-trait analysis); CRC cis rs4665809 0.590 rs1049987 chr2:26413817 C/T cg27170947 chr2:26402098 FAM59B 0.61 7.7 0.39 1.6e-13 Gut microbiome composition (summer); CRC cis rs9814567 0.502 rs12634127 chr3:134256159 A/G cg06109529 chr3:134205091 CEP63;ANAPC13 -0.48 -7.06 -0.36 9.8e-12 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs11758351 0.517 rs79958315 chr6:26221826 C/T cg10723962 chr6:26240782 HIST1H4F -0.4 -6.51 -0.34 2.74e-10 Gout;Renal underexcretion gout; CRC cis rs7113874 0.569 rs11041978 chr11:8578150 T/C cg02811074 chr11:8615871 STK33 -0.34 -5.86 -0.31 1.14e-8 Body mass index in physically active individuals;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs2580764 0.517 rs2972070 chr2:55301691 G/A cg09592903 chr2:55203963 RTN4 0.65 10.46 0.5 2.72e-22 Mean platelet volume; CRC trans rs11039798 0.623 rs588700 chr11:48449889 T/C cg15704280 chr7:45808275 SEPT13 -0.65 -6.67 -0.35 1.07e-10 Axial length; CRC cis rs561341 0.709 rs11542477 chr17:30185892 A/G cg00745463 chr17:30367425 LRRC37B 0.72 7.69 0.39 1.69e-13 Hip circumference adjusted for BMI; CRC cis rs2576037 0.526 rs605487 chr18:44444778 G/C cg23996704 chr18:44553084 KATNAL2 -0.35 -7.14 -0.37 5.89e-12 Personality dimensions; CRC cis rs2075371 0.796 rs7780583 chr7:133960716 C/G cg02659138 chr7:134003124 SLC35B4 0.39 6.62 0.34 1.46e-10 Mean platelet volume; CRC cis rs270601 0.909 rs2569265 chr5:131704519 T/C cg20512303 chr5:131592959 PDLIM4 -0.39 -6.59 -0.34 1.72e-10 Acylcarnitine levels; CRC cis rs11628318 0.713 rs1998419 chr14:103050397 C/G cg23071808 chr14:103021642 NA -0.67 -8.62 -0.43 2.84e-16 Platelet count; CRC trans rs6703335 0.870 rs10803142 chr1:243598234 A/G cg16870442 chr8:6264181 MCPH1 0.45 6.33 0.33 7.95e-10 Schizophrenia;Schizophrenia, schizoaffective disorder or bipolar disorder; CRC cis rs950169 0.580 rs11636189 chr15:85193554 G/A cg11189052 chr15:85197271 WDR73 0.65 9.56 0.47 2.9e-19 Schizophrenia; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg05885012 chr17:55980673 CUEDC1 0.45 6.47 0.34 3.6e-10 Response to antipsychotic treatment; CRC cis rs1044826 0.642 rs9833307 chr3:139181370 G/A cg15131784 chr3:139108705 COPB2 0.39 5.69 0.3 2.79e-8 Obesity-related traits; CRC cis rs10791097 0.967 rs6590512 chr11:130717916 A/G cg12179176 chr11:130786555 SNX19 -0.56 -8.26 -0.41 3.62e-15 Autism spectrum disorder or schizophrenia;Schizophrenia; CRC trans rs1005277 0.579 rs2505196 chr10:38393563 G/A cg11292332 chr7:45801988 SEPT13 -0.35 -6.26 -0.33 1.18e-9 Extrinsic epigenetic age acceleration; CRC cis rs6504950 0.800 rs9916547 chr17:53006890 G/A cg26251398 chr17:52985966 TOM1L1 0.37 5.65 0.3 3.48e-8 Breast cancer; CRC cis rs1552244 1.000 rs7652935 chr3:10151138 T/C cg10729496 chr3:10149963 C3orf24 0.55 7.1 0.36 7.93e-12 Alzheimer's disease; CRC cis rs1129187 0.720 rs9471972 chr6:42915021 G/A cg02359409 chr6:42947317 PEX6 -0.61 -9.76 -0.47 6.45e-20 Alzheimer's disease in APOE e4+ carriers; CRC cis rs896854 0.625 rs4735335 chr8:95973327 G/C cg16049864 chr8:95962084 TP53INP1 -0.65 -11.8 -0.55 5.04e-27 Type 2 diabetes; CRC trans rs66573146 1.000 rs6812391 chr4:6963893 G/A cg07817883 chr1:32538562 TMEM39B 1.52 13.22 0.59 2.77e-32 Granulocyte percentage of myeloid white cells; CRC cis rs7264396 0.563 rs2425120 chr20:34324456 A/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.49 -6.55 -0.34 2.15e-10 Total cholesterol levels; CRC cis rs7618915 0.501 rs11130308 chr3:52639257 G/C cg18099408 chr3:52552593 STAB1 -0.48 -8.08 -0.41 1.22e-14 Bipolar disorder; CRC cis rs780096 0.526 rs13472 chr2:27600239 G/A cg21248554 chr2:27665150 KRTCAP3 -0.32 -7.2 -0.37 4.14e-12 Total body bone mineral density; CRC cis rs4803468 1.000 rs2241706 chr19:41912807 A/G cg09537434 chr19:41945824 ATP5SL -0.98 -18.86 -0.72 2.59e-54 Height; CRC cis rs9910055 0.762 rs4239142 chr17:42205876 A/G cg19774624 chr17:42201019 HDAC5 0.6 8.74 0.43 1.23e-16 Total body bone mineral density; CRC cis rs2991971 1.000 rs2934859 chr1:46017836 C/T cg15605315 chr1:45957053 TESK2 0.43 6.62 0.34 1.48e-10 High light scatter reticulocyte count; CRC cis rs2832191 0.671 rs2409332 chr21:30512779 G/A cg24692254 chr21:30365293 RNF160 -0.57 -8.34 -0.42 2.04e-15 Dental caries; CRC cis rs12230513 0.732 rs60643523 chr12:55842928 A/G cg19537932 chr12:55886519 OR6C68 -0.73 -9.5 -0.46 4.47e-19 Contrast sensitivity; CRC cis rs10504229 0.817 rs35207430 chr8:58167614 G/A cg24829409 chr8:58192753 C8orf71 -0.63 -10.78 -0.51 2.03e-23 Developmental language disorder (linguistic errors); CRC cis rs13108904 0.935 rs2199956 chr4:1248919 A/G cg20092199 chr4:1342459 KIAA1530 0.36 6.35 0.33 7.29e-10 Obesity-related traits; CRC cis rs6952808 0.723 rs4721264 chr7:2012997 G/A cg21782813 chr7:2030301 MAD1L1 0.5 8.43 0.42 1.11e-15 Bipolar disorder and schizophrenia; CRC cis rs10789491 1.000 rs4660956 chr1:47158486 A/G cg15501359 chr1:47185051 KIAA0494 0.63 7.32 0.37 1.91e-12 Response to hepatitis C treatment; CRC cis rs597539 0.521 rs7943745 chr11:68605828 A/G cg11716795 chr11:68671300 MRPL21;IGHMBP2 -0.51 -7.43 -0.38 9.18e-13 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs4363385 0.818 rs472076 chr1:153013742 G/T cg25856811 chr1:152973957 SPRR3 -0.25 -6.9 -0.36 2.64e-11 Inflammatory skin disease; CRC cis rs9291683 0.546 rs13110307 chr4:10044364 T/C cg00071950 chr4:10020882 SLC2A9 0.63 11.19 0.52 7.86e-25 Bone mineral density; CRC trans rs11722228 1.000 rs6825187 chr4:9915325 T/C cg26043149 chr18:55253948 FECH -0.72 -10.47 -0.5 2.51e-22 Gout;Urate levels;Serum uric acid levels; CRC cis rs8017423 0.626 rs8003363 chr14:90826840 T/C cg14092571 chr14:90743983 NA 0.39 5.88 0.31 1.02e-8 Mortality in heart failure; CRC cis rs853679 0.517 rs9380057 chr6:28104634 G/T cg15845792 chr6:28175446 NA 1.01 13.54 0.6 1.59e-33 Depression; CRC cis rs7618915 0.547 rs68021750 chr3:52624769 G/A cg10802521 chr3:52805072 NEK4 -0.59 -9.1 -0.45 8.89e-18 Bipolar disorder; CRC cis rs7259376 0.694 rs75653200 chr19:22579503 G/T cg02657401 chr19:22469223 NA 0.31 6.79 0.35 5.21e-11 Menopause (age at onset); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg03729288 chr17:7232752 NEURL4 0.39 6.24 0.33 1.35e-9 Liver disease severity in Alagille syndrome; CRC cis rs28489187 0.706 rs2300637 chr1:85822772 T/C cg17737388 chr1:85724454 C1orf52 0.38 5.7 0.3 2.67e-8 Asymmetrical dimethylarginine levels;Serum dimethylarginine levels (asymmetric/symetric ratio); CRC cis rs6461049 0.765 rs1476887 chr7:2151633 T/C cg04267008 chr7:1944627 MAD1L1 -0.49 -6.75 -0.35 6.56e-11 Schizophrenia; CRC trans rs10504229 0.906 rs66480865 chr8:58187100 C/T cg04077850 chr5:125800366 GRAMD3 0.37 6.27 0.33 1.15e-9 Developmental language disorder (linguistic errors); CRC cis rs12762955 0.561 rs7076107 chr10:1043647 T/C cg19847866 chr10:1019161 NA 0.4 5.75 0.3 1.99e-8 Response to angiotensin II receptor blocker therapy; CRC cis rs11641365 0.517 rs73262667 chr16:88779753 C/T cg00034003 chr16:88779146 CTU2 0.66 6.56 0.34 2.09e-10 Autism spectrum disorder-related traits; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg16071359 chr2:169312933 LASS6 0.48 6.7 0.35 9.22e-11 Response to antipsychotic treatment; CRC cis rs875971 0.545 rs12673308 chr7:65631361 C/A cg05627663 chr7:65219948 SNORA22;CCT6P1 0.6 7.73 0.39 1.29e-13 Aortic root size; CRC cis rs17270561 0.609 rs1165155 chr6:25795577 A/T cg17691542 chr6:26056736 HIST1H1C 0.52 7.09 0.36 8.45e-12 Iron status biomarkers; CRC cis rs9649213 0.593 rs7807555 chr7:97957517 G/A cg00277769 chr7:97922759 BAIAP2L1 -0.61 -10.65 -0.51 5.74e-23 Prostate cancer (SNP x SNP interaction); CRC cis rs7945705 0.875 rs2653616 chr11:8885892 A/G cg00186954 chr11:8933980 ST5;C11orf17 -0.45 -7.2 -0.37 4.04e-12 Hemoglobin concentration; CRC cis rs28655083 0.636 rs61117898 chr16:77050736 A/C cg01753188 chr16:77233325 SYCE1L;MON1B -0.6 -7.15 -0.37 5.7e-12 Lobe attachment (rater-scored or self-reported); CRC cis rs11098499 0.863 rs6833334 chr4:120504227 C/T cg09307838 chr4:120376055 NA 0.7 10.33 0.49 7.6e-22 Corneal astigmatism; CRC cis rs1267303 0.682 rs1998545 chr1:46954587 C/T cg08533674 chr1:46993347 NA -0.39 -5.67 -0.3 3.21e-8 Monobrow; CRC cis rs6424115 0.733 rs2502996 chr1:24199041 T/C cg09473613 chr1:24152604 HMGCL 0.35 5.67 0.3 3.18e-8 Immature fraction of reticulocytes; CRC cis rs7208859 0.673 rs216420 chr17:28938508 C/T cg13385521 chr17:29058706 SUZ12P 0.5 6.2 0.32 1.67e-9 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs10479542 0.544 rs7706275 chr5:178990305 A/G cg21226059 chr5:178986404 RUFY1 0.38 6.08 0.32 3.29e-9 Lung cancer; CRC cis rs9311474 0.508 rs6805156 chr3:52609362 T/C cg11645453 chr3:52864694 ITIH4 0.35 6.3 0.33 9.46e-10 Electroencephalogram traits; CRC cis rs6743226 0.934 rs4234100 chr2:242265273 A/G cg10021735 chr2:242295487 FARP2 -0.45 -6.65 -0.34 1.24e-10 Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI in non-smokers; CRC cis rs8060686 0.668 rs12448991 chr16:68218894 T/A cg08314208 chr16:67682810 RLTPR -0.6 -6.5 -0.34 2.93e-10 HDL cholesterol;Metabolic syndrome; CRC cis rs854555 0.581 rs854537 chr7:94910248 C/T cg19678392 chr7:94953810 PON1 -0.46 -6.08 -0.32 3.38e-9 Response to TNF antagonist treatment; CRC cis rs12681287 0.640 rs13280468 chr8:87338452 C/T cg27223183 chr8:87520930 FAM82B -0.52 -7.07 -0.36 9.35e-12 Caudate activity during reward; CRC cis rs10504229 0.593 rs76922080 chr8:57985837 C/G cg24829409 chr8:58192753 C8orf71 -0.53 -6.19 -0.32 1.79e-9 Developmental language disorder (linguistic errors); CRC cis rs780096 0.587 rs6743819 chr2:27567407 G/T cg24768116 chr2:27665128 KRTCAP3 -0.32 -7.14 -0.37 5.94e-12 Total body bone mineral density; CRC cis rs12477438 0.798 rs12468419 chr2:99579680 G/A cg26064155 chr2:99771622 LIPT1;TSGA10 -0.64 -8.82 -0.44 6.85e-17 Chronic sinus infection; CRC cis rs1153858 1.000 rs7163720 chr15:45639374 G/A cg14582100 chr15:45693742 SPATA5L1 0.28 5.91 0.31 8.48e-9 Homoarginine levels; CRC cis rs4665809 0.878 rs892448 chr2:26366205 A/G cg26119090 chr2:26468346 HADHA;HADHB -0.67 -8.37 -0.42 1.7e-15 Gut microbiome composition (summer); CRC cis rs6748734 1.000 rs4293565 chr2:241834770 A/G cg07537917 chr2:241836409 C2orf54 -0.22 -6.0 -0.31 5.26e-9 Urinary metabolites; CRC cis rs17539620 0.624 rs62432738 chr6:154835674 T/C cg20019720 chr6:154832845 CNKSR3 0.5 8.21 0.41 5.03e-15 Lipoprotein (a) levels; CRC cis rs4242434 0.927 rs2291232 chr8:22464064 A/G cg03733263 chr8:22462867 KIAA1967 1.01 19.29 0.73 5.52e-56 Exploratory eye movement dysfunction in schizophrenia (cognitive search score); CRC cis rs4891159 0.548 rs10782013 chr18:74128348 C/T cg24786174 chr18:74118243 ZNF516 0.9 20.85 0.75 4.04e-62 Longevity; CRC cis rs7809950 0.954 rs2894466 chr7:107242909 G/A cg23024343 chr7:107201750 COG5 0.64 9.15 0.45 6.22e-18 Coronary artery disease; CRC cis rs4867766 0.789 rs17781920 chr5:173955939 G/A cg20434911 chr5:173954559 NA -0.8 -9.1 -0.45 8.58e-18 Stroke; CRC cis rs9611565 0.694 rs5758389 chr22:41941749 T/C cg06634786 chr22:41940651 POLR3H -0.57 -7.11 -0.36 7.48e-12 Vitiligo; CRC cis rs9308731 0.644 rs1054873 chr2:111876148 G/A cg04202892 chr2:111875749 ACOXL 0.44 7.07 0.36 9.17e-12 Chronic lymphocytic leukemia; CRC trans rs11039798 1.000 rs7104642 chr11:48588534 C/T cg03929089 chr4:120376271 NA 0.65 6.38 0.33 6.18e-10 Axial length; CRC cis rs7208859 0.673 rs60020217 chr17:29185054 G/A cg01831904 chr17:28903510 LRRC37B2 -0.55 -5.72 -0.3 2.33e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs34375054 0.526 rs34764657 chr12:125679639 A/G cg05341575 chr12:125625032 AACS -0.39 -5.95 -0.31 6.85e-9 Post bronchodilator FEV1/FVC ratio; CRC cis rs478222 1.000 rs478222 chr2:25301755 A/T cg22495460 chr2:25135724 ADCY3 0.43 6.4 0.33 5.39e-10 Type 1 diabetes; CRC cis rs10504229 0.683 rs10504225 chr8:58145121 A/T cg05313129 chr8:58192883 C8orf71 -0.43 -6.1 -0.32 3.06e-9 Developmental language disorder (linguistic errors); CRC cis rs478304 0.817 rs524475 chr11:65518065 T/A cg08755490 chr11:65554678 OVOL1 0.42 6.15 0.32 2.24e-9 Acne (severe); CRC cis rs11212617 1.000 rs227092 chr11:108236783 G/T cg01991180 chr11:108092276 ATM;NPAT 0.43 6.32 0.33 8.53e-10 Response to metformin in type 2 diabetes (glycemic); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg12581662 chr19:36706085 ZNF565;ZNF146 0.45 6.78 0.35 5.62e-11 Response to antipsychotic treatment; CRC cis rs965469 1.000 rs6051672 chr20:3224819 C/T cg25506879 chr20:3388711 C20orf194 -0.4 -5.7 -0.3 2.61e-8 IFN-related cytopenia; CRC cis rs2019137 0.560 rs10206269 chr2:113990393 C/A cg19083407 chr2:113993142 PAX8;LOC440839;LOC654433 0.56 8.21 0.41 5.01e-15 Lymphocyte counts; CRC cis rs9372498 0.536 rs62422235 chr6:118971913 G/A cg24463073 chr6:118973353 C6orf204 0.53 6.55 0.34 2.2e-10 Diastolic blood pressure; CRC cis rs3815700 0.920 rs10426856 chr19:33096406 A/G cg05355328 chr19:33096524 ANKRD27 0.51 5.7 0.3 2.63e-8 Eosinophilic esophagitis; CRC cis rs9527 1.000 rs9527 chr10:104623578 C/T cg15744005 chr10:104629667 AS3MT -0.38 -6.61 -0.34 1.54e-10 Arsenic metabolism; CRC cis rs2732480 0.577 rs2732481 chr12:48736985 T/G cg21466736 chr12:48725269 NA -0.59 -8.67 -0.43 2.02e-16 Hemoglobin concentration;Red blood cell count;Hematocrit; CRC cis rs9916302 0.851 rs7220650 chr17:37487168 A/G cg07936489 chr17:37558343 FBXL20 0.83 13.16 0.59 4.6e-32 Glomerular filtration rate (creatinine); CRC cis rs9322193 0.923 rs9479810 chr6:150072495 C/T cg07701084 chr6:150067640 NUP43 0.46 6.47 0.34 3.58e-10 Lung cancer; CRC cis rs7618915 0.501 rs3733039 chr3:52719088 C/T cg15147215 chr3:52552868 STAB1 -0.64 -11.04 -0.52 2.57e-24 Bipolar disorder; CRC cis rs875971 0.660 rs2013222 chr7:66035936 C/G cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.39 -5.78 -0.3 1.69e-8 Aortic root size; CRC trans rs2321882 0.834 rs61953982 chr13:59466140 T/G cg04268950 chr11:130298854 ADAMTS8 -0.45 -5.99 -0.31 5.64e-9 Body mass index; CRC cis rs1712517 0.771 rs11191672 chr10:105138961 C/T cg05636881 chr10:105038444 INA 0.45 7.84 0.4 6.48e-14 Migraine; CRC cis rs6964587 1.000 rs7797369 chr7:91570615 C/A cg17063962 chr7:91808500 NA -0.78 -13.48 -0.6 2.8e-33 Breast cancer; CRC cis rs62458065 0.513 rs10245103 chr7:32534829 T/G cg20159608 chr7:32802032 NA -0.5 -6.44 -0.33 4.3e-10 Metabolite levels (HVA/MHPG ratio); CRC cis rs13191362 0.507 rs2155506 chr6:163035342 G/A cg06582575 chr6:163149167 PACRG;PARK2 -0.55 -8.63 -0.43 2.69e-16 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs7113874 0.569 rs10840072 chr11:8569360 T/C cg02811074 chr11:8615871 STK33 -0.34 -5.86 -0.31 1.14e-8 Body mass index in physically active individuals;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs637571 0.546 rs10791827 chr11:65596546 C/A cg04055107 chr11:65626734 MUS81;CFL1 -0.44 -6.01 -0.31 5e-9 Eosinophil percentage of white cells; CRC cis rs7618915 0.547 rs34610142 chr3:52708429 G/A cg07507251 chr3:52567010 NT5DC2 0.46 6.6 0.34 1.68e-10 Bipolar disorder; CRC cis rs28386778 0.897 rs2727328 chr17:61923564 G/A cg22520471 chr17:61851767 DDX42;CCDC47 0.74 11.65 0.54 1.76e-26 Prudent dietary pattern; CRC trans rs875971 0.660 rs2191268 chr7:66110224 C/T cg04238871 chr10:126431886 FAM53B -0.4 -6.06 -0.32 3.74e-9 Aortic root size; CRC cis rs7614311 0.636 rs3821902 chr3:63941697 T/G cg22134162 chr3:63841271 THOC7 -0.56 -5.93 -0.31 7.62e-9 Lung function (FVC);Lung function (FEV1); CRC cis rs7705042 0.865 rs4391200 chr5:141509537 A/G cg08523384 chr5:141488047 NDFIP1 -0.32 -5.77 -0.3 1.87e-8 Asthma; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg16841147 chr20:33543707 GSS 0.37 6.04 0.32 4.12e-9 Liver disease severity in Alagille syndrome; CRC cis rs172166 0.516 rs1225715 chr6:28113373 C/T cg06470822 chr6:28175283 NA -0.62 -9.19 -0.45 4.67e-18 Cardiac Troponin-T levels; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg12351856 chr18:19192308 SNRPD1 0.39 6.58 0.34 1.9e-10 Liver disease severity in Alagille syndrome; CRC cis rs6866344 0.570 rs1071882 chr5:178136040 C/T cg10224037 chr5:178157518 ZNF354A 0.72 10.65 0.51 5.84e-23 Neutrophil percentage of white cells; CRC cis rs56114371 0.777 rs200483 chr6:27774824 C/T cg26958806 chr6:27640298 NA 0.67 5.75 0.3 1.99e-8 Breast cancer; CRC trans rs10506458 0.915 rs17763441 chr12:63418335 T/C cg03429785 chr15:59498649 MYO1E;LDHAL6B -1.35 -20.32 -0.75 4.68e-60 Hemostatic factors and hematological phenotypes; CRC trans rs9329221 0.905 rs28712068 chr8:10251145 G/C cg06636001 chr8:8085503 FLJ10661 -0.55 -8.66 -0.43 2.12e-16 Neuroticism; CRC cis rs56399783 0.901 rs73051415 chr7:2850643 C/T cg19731401 chr7:2775893 GNA12 0.63 6.6 0.34 1.67e-10 Childhood ear infection; CRC cis rs7927771 0.524 rs12286721 chr11:47701528 G/T cg20307385 chr11:47447363 PSMC3 -0.48 -7.19 -0.37 4.49e-12 Subjective well-being; CRC cis rs55702914 0.742 rs34555121 chr2:198166053 C/T cg03934865 chr2:198174659 NA 0.41 7.18 0.37 4.76e-12 Major depression and alcohol dependence; CRC cis rs2180341 0.824 rs9321076 chr6:127655614 G/A cg24812749 chr6:127587940 RNF146 0.95 13.72 0.6 3.35e-34 Breast cancer; CRC trans rs7267979 1.000 rs6050609 chr20:25411751 A/G cg17903999 chr18:56338584 MALT1 0.42 6.98 0.36 1.6e-11 Liver enzyme levels (alkaline phosphatase); CRC cis rs6788895 1.000 rs1991781 chr3:150468433 G/A cg09723797 chr3:150481914 SIAH2 0.88 5.98 0.31 5.81e-9 Breast cancer; CRC cis rs807669 0.807 rs807431 chr22:19242361 G/A cg02655711 chr22:19163373 SLC25A1 0.74 13.63 0.6 7.51e-34 Metabolite levels; CRC cis rs9926296 0.568 rs1230 chr16:89804855 A/G cg27121462 chr16:89883253 FANCA -0.58 -9.07 -0.45 1.14e-17 Vitiligo; CRC cis rs875971 1.000 rs1565531 chr7:65663113 T/A cg12463550 chr7:65579703 CRCP -0.49 -7.06 -0.36 9.71e-12 Aortic root size; CRC cis rs28386778 0.897 rs9915552 chr17:61869095 G/A cg25654072 chr17:61904446 PSMC5;FTSJ3 0.74 11.57 0.54 3.23e-26 Prudent dietary pattern; CRC cis rs9322193 0.962 rs62441335 chr6:150113794 G/A cg07701084 chr6:150067640 NUP43 0.47 6.61 0.34 1.51e-10 Lung cancer; CRC cis rs875971 0.545 rs6460276 chr7:65647277 G/A cg02869306 chr7:64672164 INTS4L1 -0.43 -6.41 -0.33 5.17e-10 Aortic root size; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg21413108 chr3:122233679 KPNA1 0.43 6.11 0.32 2.81e-9 Anxiety disorder; CRC cis rs2032447 0.802 rs12346 chr6:26097046 T/C cg12310025 chr6:25882481 NA -0.49 -6.69 -0.35 9.66e-11 Intelligence (multi-trait analysis); CRC cis rs3736485 0.873 rs12442725 chr15:51874412 C/T cg08986416 chr15:51914746 DMXL2 -0.46 -6.56 -0.34 2.11e-10 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC trans rs5756813 0.668 rs4821704 chr22:38146585 A/G cg19894588 chr14:64061835 NA -0.48 -6.41 -0.33 5.14e-10 Optic cup area;Vertical cup-disc ratio; CRC trans rs9987353 0.876 rs73199666 chr8:9125730 C/A cg06636001 chr8:8085503 FLJ10661 -0.47 -6.29 -0.33 1e-9 Recombination measurement; CRC cis rs6762 0.748 rs28735718 chr11:839629 A/G cg11173246 chr11:841376 TSPAN4;POLR2L -0.34 -5.68 -0.3 2.97e-8 Mean platelet volume; CRC cis rs6460942 0.630 rs1866650 chr7:12396897 C/T cg06484146 chr7:12443880 VWDE -0.61 -6.43 -0.33 4.5e-10 Coronary artery disease; CRC cis rs1707322 1.000 rs946524 chr1:46487560 A/G cg06784218 chr1:46089804 CCDC17 -0.52 -9.42 -0.46 8.2e-19 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC trans rs2821260 0.902 rs12131816 chr1:72529866 A/G cg20998090 chr9:86536513 KIF27 -0.51 -6.29 -0.33 9.92e-10 Intelligence (multi-trait analysis); CRC trans rs3749237 0.929 rs62260715 chr3:49829326 G/A cg21665057 chr3:196295764 WDR53;FBXO45 0.51 6.76 0.35 6.21e-11 Resting heart rate; CRC cis rs9925964 0.933 rs11150604 chr16:31037020 A/T cg03418659 chr16:31128414 MYST1 0.46 6.66 0.34 1.16e-10 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs2408955 0.522 rs4760612 chr12:48421856 C/T cg15465823 chr12:48382534 COL2A1 -0.38 -6.3 -0.33 9.61e-10 Glycated hemoglobin levels; CRC trans rs11581859 0.950 rs72730330 chr1:99395692 G/A cg12183875 chr3:169587454 LRRC31 0.28 6.34 0.33 7.78e-10 Response to cognitive-behavioural therapy in anxiety disorder; CRC cis rs35306767 0.903 rs12244253 chr10:889320 G/T cg26597838 chr10:835615 NA 0.92 10.93 0.52 6.12e-24 Eosinophil percentage of granulocytes; CRC cis rs116095464 0.558 rs7356696 chr5:284251 A/G cg22496380 chr5:211416 CCDC127 -0.89 -10.1 -0.49 4.58e-21 Breast cancer; CRC cis rs10733682 0.524 rs10987418 chr9:129462563 A/G cg00232160 chr9:129468157 NA 0.33 5.66 0.3 3.32e-8 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs2288073 0.965 rs72789923 chr2:24394504 A/C cg06627628 chr2:24431161 ITSN2 -0.73 -9.79 -0.48 4.91e-20 Venous thromboembolism (SNP x SNP interaction); CRC trans rs875971 0.660 rs2191268 chr7:66110224 C/T cg01166180 chr19:36606541 POLR2I;TBCB -0.4 -6.01 -0.31 4.93e-9 Aortic root size; CRC cis rs6942756 0.688 rs2718089 chr7:128927022 G/T cg02491457 chr7:128862824 NA 0.67 9.38 0.46 1.15e-18 White matter hyperintensity burden; CRC cis rs1707322 1.000 rs6429580 chr1:46275648 A/G cg06784218 chr1:46089804 CCDC17 0.51 8.97 0.44 2.31e-17 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs11764590 0.715 rs62444907 chr7:2083267 C/T cg02825527 chr7:2087843 MAD1L1 -0.49 -5.82 -0.31 1.38e-8 Neuroticism; CRC cis rs798766 1.000 rs1665366 chr4:1728381 A/G cg05874882 chr4:1763078 NA 0.4 6.94 0.36 2.06e-11 Bladder cancer;Urinary bladder cancer; CRC cis rs7618915 0.547 rs4687638 chr3:52651966 A/C cg10802521 chr3:52805072 NEK4 -0.58 -8.83 -0.44 6.26e-17 Bipolar disorder; CRC cis rs4665809 1.000 rs4665817 chr2:26305167 G/A cg04944784 chr2:26401820 FAM59B -0.66 -8.1 -0.41 1.1e-14 Gut microbiome composition (summer); CRC cis rs6903823 0.508 rs1150724 chr6:28250236 C/T cg21251018 chr6:28226885 NKAPL 0.56 9.47 0.46 5.53e-19 Pulmonary function; CRC trans rs9858542 0.953 rs7648841 chr3:49416825 G/A cg21665057 chr3:196295764 WDR53;FBXO45 -0.62 -8.52 -0.43 5.85e-16 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs10883723 0.810 rs17782574 chr10:104279394 G/A cg11453585 chr10:104263688 ACTR1A;SUFU 0.9 16.72 0.68 7.3e-46 Allergic disease (asthma, hay fever or eczema); CRC cis rs6585424 1.000 rs34386571 chr10:81939432 C/T cg11900509 chr10:81946545 ANXA11 -0.76 -9.33 -0.46 1.56e-18 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs1799949 0.965 rs11651623 chr17:41329847 G/A cg01879757 chr17:41196368 BRCA1 -0.41 -6.18 -0.32 1.86e-9 Menopause (age at onset); CRC cis rs4862750 0.794 rs1030382 chr4:187903782 T/G cg27532560 chr4:187881888 NA -0.54 -9.41 -0.46 8.95e-19 Lobe attachment (rater-scored or self-reported); CRC cis rs6860806 0.661 rs334902 chr5:131586559 C/G cg04518342 chr5:131593106 PDLIM4 0.47 8.61 0.43 3.09e-16 Breast cancer; CRC cis rs6429082 0.782 rs704705 chr1:235612320 C/T cg26050004 chr1:235667680 B3GALNT2 -0.56 -7.47 -0.38 7.31e-13 Adiposity; CRC cis rs6089584 0.850 rs6142939 chr20:60627729 A/G cg18761221 chr20:60518478 NA 0.47 7.72 0.39 1.37e-13 Body mass index; CRC cis rs7781266 0.739 rs6949831 chr7:133081470 G/C cg03336402 chr7:133662267 EXOC4 -0.47 -5.65 -0.3 3.5e-8 Educational attainment (college completion); CRC cis rs10540 1.000 rs61876333 chr11:487136 G/A cg15790184 chr11:494944 RNH1 0.62 5.89 0.31 9.5e-9 Body mass index; CRC cis rs11229555 0.645 rs10896778 chr11:58193925 T/G cg15696309 chr11:58395628 NA -0.82 -10.31 -0.49 8.59e-22 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; CRC cis rs1881797 0.932 rs41305741 chr1:247689543 A/G cg05639522 chr1:247681581 NA 0.48 7.3 0.37 2.15e-12 Acute lymphoblastic leukemia (childhood); CRC cis rs2832191 0.933 rs2832236 chr21:30547602 C/T cg24692254 chr21:30365293 RNF160 -0.6 -10.11 -0.49 4.19e-21 Dental caries; CRC cis rs853679 0.517 rs35227624 chr6:28132726 A/G cg12273811 chr6:28175739 NA 0.73 9.16 0.45 5.8e-18 Depression; CRC cis rs6804368 0.649 rs9850620 chr3:30767114 C/T cg06106510 chr3:30762233 NA -0.39 -6.93 -0.36 2.22e-11 Blood metabolite levels; CRC trans rs17685 0.753 rs1637039 chr7:75693009 C/T cg19862616 chr7:65841803 NCRNA00174 1.0 18.78 0.72 5.56e-54 Coffee consumption;Coffee consumption (cups per day); CRC cis rs9325144 0.647 rs34311455 chr12:39060889 C/T cg26384229 chr12:38710491 ALG10B -0.52 -7.33 -0.37 1.79e-12 Morning vs. evening chronotype; CRC cis rs3820068 0.603 rs6695903 chr1:15985940 C/T cg24675056 chr1:15929824 NA 0.5 6.97 0.36 1.76e-11 Systolic blood pressure; CRC cis rs72945132 0.882 rs67927691 chr11:70128786 C/A cg00319359 chr11:70116639 PPFIA1 0.67 7.4 0.38 1.13e-12 Coronary artery disease; CRC trans rs10411161 0.702 rs10423835 chr19:52387322 A/G cg22319618 chr22:45562946 NUP50 -0.66 -7.28 -0.37 2.41e-12 Breast cancer; CRC trans rs7395662 1.000 rs7945192 chr11:48580737 C/T cg21153622 chr11:89784906 NA -0.44 -7.12 -0.37 6.86e-12 HDL cholesterol; CRC cis rs7917772 0.582 rs7899004 chr10:104341435 C/T cg11453585 chr10:104263688 ACTR1A;SUFU -0.81 -14.68 -0.63 7.12e-38 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC cis rs9300255 0.739 rs6633 chr12:123745809 G/T cg00376283 chr12:123451042 ABCB9 -0.55 -6.21 -0.32 1.63e-9 Neutrophil percentage of white cells; CRC cis rs1448094 0.717 rs55811543 chr12:86290936 C/T cg02569458 chr12:86230093 RASSF9 0.39 6.34 0.33 7.77e-10 Major depressive disorder; CRC cis rs11098499 0.909 rs28632018 chr4:120386730 T/C cg24375607 chr4:120327624 NA 0.5 7.72 0.39 1.4e-13 Corneal astigmatism; CRC cis rs17376456 0.825 rs1470150 chr5:93138654 C/T cg25358565 chr5:93447407 FAM172A -0.87 -9.28 -0.46 2.3e-18 Diabetic retinopathy; CRC trans rs1864729 1.000 rs2583506 chr8:98281847 G/A cg08679828 chr8:102218111 ZNF706 -0.63 -7.62 -0.39 2.77e-13 Estradiol plasma levels (breast cancer); CRC cis rs7586879 0.663 rs6760328 chr2:25077991 T/C cg22495460 chr2:25135724 ADCY3 -0.8 -12.82 -0.58 8.81e-31 Body mass index; CRC cis rs9649213 0.593 rs6948540 chr7:97960066 A/G cg21770322 chr7:97807741 LMTK2 0.51 8.29 0.42 2.88e-15 Prostate cancer (SNP x SNP interaction); CRC cis rs72634258 0.519 rs744001 chr1:7934557 G/A cg26816564 chr1:7831052 VAMP3 0.78 8.78 0.44 9.39e-17 Inflammatory bowel disease; CRC trans rs8089364 0.917 rs11660069 chr18:57885413 A/G cg05871254 chr17:14213225 HS3ST3B1 -0.45 -6.45 -0.34 3.97e-10 Type 2 diabetes;Body mass index; CRC cis rs10504229 0.724 rs72650827 chr8:58126884 A/T cg24829409 chr8:58192753 C8orf71 -0.55 -8.03 -0.4 1.71e-14 Developmental language disorder (linguistic errors); CRC cis rs1153858 1.000 rs2114501 chr15:45670316 G/A cg21132104 chr15:45694354 SPATA5L1 0.57 8.29 0.42 2.85e-15 Homoarginine levels; CRC cis rs11212617 1.000 rs7931930 chr11:108268286 G/T cg14761454 chr11:108092087 ATM;NPAT 0.41 5.94 0.31 7.41e-9 Response to metformin in type 2 diabetes (glycemic); CRC cis rs7618915 0.508 rs11717043 chr3:52656092 A/T cg11645453 chr3:52864694 ITIH4 0.35 6.2 0.32 1.73e-9 Bipolar disorder; CRC cis rs1336900 0.641 rs6587756 chr1:150546865 A/T cg18016565 chr1:150552671 MCL1 -0.53 -7.8 -0.39 8.34e-14 Blood protein levels; CRC cis rs7746199 0.668 rs34864796 chr6:27459923 G/A cg08798685 chr6:27730294 NA -0.74 -6.65 -0.34 1.22e-10 Gait speed in old age;Autism spectrum disorder or schizophrenia; CRC cis rs34172651 0.917 rs11074654 chr16:24813743 A/G cg06505273 chr16:24850292 NA 0.38 5.81 0.3 1.5e-8 Intelligence (multi-trait analysis); CRC cis rs7811142 1.000 rs60257855 chr7:100026780 G/C cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.18 17.44 0.69 1.06e-48 Platelet count; CRC cis rs13108904 0.870 rs13110563 chr4:1255772 G/C cg16405210 chr4:1374714 KIAA1530 -0.43 -6.07 -0.32 3.44e-9 Obesity-related traits; CRC cis rs6662572 0.906 rs11590549 chr1:46086329 C/T cg06784218 chr1:46089804 CCDC17 -0.39 -6.07 -0.32 3.61e-9 Blood protein levels; CRC trans rs1005277 0.522 rs1208767 chr10:38042295 G/T cg27523141 chr10:43048294 ZNF37B 0.45 6.46 0.34 3.84e-10 Extrinsic epigenetic age acceleration; CRC trans rs1814175 0.904 rs1846289 chr11:49620253 G/A cg15704280 chr7:45808275 SEPT13 -0.97 -18.03 -0.7 5.04e-51 Height; CRC cis rs79387448 0.745 rs1989399 chr2:103166742 G/A cg00507830 chr2:103233733 NA 0.53 5.83 0.31 1.31e-8 Gut microbiota (bacterial taxa); CRC trans rs8123881 0.733 rs7268466 chr20:15810676 C/T cg05236530 chr12:7362357 PEX5 -0.56 -6.33 -0.33 8e-10 Body mass index; CRC cis rs7674212 0.539 rs6821617 chr4:104128410 G/A cg16532752 chr4:104119610 CENPE -0.41 -5.85 -0.31 1.19e-8 Type 2 diabetes; CRC cis rs6831352 0.819 rs1230158 chr4:99990186 T/C cg13256891 chr4:100009986 ADH5 0.48 6.58 0.34 1.88e-10 Alcohol dependence; CRC cis rs4927850 1.000 rs7627706 chr3:195753353 A/C cg00031303 chr3:195681400 NA 0.51 7.32 0.37 1.88e-12 Pancreatic cancer; CRC cis rs2832191 0.740 rs2832168 chr21:30463695 G/A cg08807101 chr21:30365312 RNF160 0.71 11.35 0.53 2.05e-25 Dental caries; CRC trans rs629535 0.551 rs62513429 chr8:70149995 A/C cg21567404 chr3:27674614 NA -0.9 -13.04 -0.58 1.25e-31 Dupuytren's disease; CRC cis rs4588572 0.643 rs1529499 chr5:77721431 T/C cg11446398 chr5:77624930 NA 0.46 6.38 0.33 6.05e-10 Triglycerides; CRC cis rs7044106 0.791 rs10984995 chr9:123479210 C/T cg09586646 chr9:123605570 PSMD5;LOC253039 0.61 8.99 0.44 1.95e-17 Hip circumference adjusted for BMI; CRC cis rs7666738 0.830 rs10022331 chr4:98960392 C/A cg17366294 chr4:99064904 C4orf37 0.43 7.34 0.38 1.69e-12 Colonoscopy-negative controls vs population controls; CRC cis rs7274811 0.652 rs291672 chr20:31951168 G/A cg03904042 chr20:32255491 NECAB3;C20orf134 0.42 6.14 0.32 2.4e-9 Height; CRC trans rs656319 0.559 rs17689037 chr8:9974858 C/T cg06636001 chr8:8085503 FLJ10661 -0.47 -6.98 -0.36 1.65e-11 Myopia (pathological); CRC cis rs9341808 0.718 rs9294171 chr6:80839815 C/T cg08355045 chr6:80787529 NA 0.43 6.99 0.36 1.53e-11 Sitting height ratio; CRC trans rs7824557 0.603 rs2249804 chr8:11215617 C/G cg16141378 chr3:129829833 LOC729375 -0.42 -6.31 -0.33 8.95e-10 Retinal vascular caliber; CRC cis rs17345786 0.861 rs74768235 chr3:101142821 T/C cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.58 6.72 0.35 8e-11 Colonoscopy-negative controls vs population controls; CRC cis rs924607 0.898 rs905193 chr5:635095 T/C cg24163568 chr5:669837 TPPP 0.43 6.83 0.35 4.09e-11 Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia; CRC cis rs7937682 0.883 rs659529 chr11:111436896 T/A cg09085632 chr11:111637200 PPP2R1B -0.97 -18.46 -0.71 9.7e-53 Primary sclerosing cholangitis; CRC trans rs875971 0.502 rs11769702 chr7:65720516 A/C cg02869306 chr7:64672164 INTS4L1 -0.44 -6.21 -0.32 1.57e-9 Aortic root size; CRC cis rs875971 1.000 rs4718307 chr7:65610988 A/G cg00343986 chr7:65444356 GUSB -0.45 -6.66 -0.34 1.12e-10 Aortic root size; CRC cis rs4332037 0.539 rs56305291 chr7:2048706 A/G cg24505167 chr7:1915268 MAD1L1 -0.44 -6.04 -0.32 4.13e-9 Bipolar disorder; CRC cis rs4822044 0.561 rs132781 chr22:42046122 T/G cg06634786 chr22:41940651 POLR3H 0.55 6.09 0.32 3.2e-9 Cannabis dependence symptom count; CRC trans rs6561151 0.957 rs7995004 chr13:44478820 C/T cg17145862 chr1:211918768 LPGAT1 0.5 7.15 0.37 5.78e-12 Crohn's disease; CRC cis rs7937682 0.710 rs674230 chr11:111437887 A/G cg09085632 chr11:111637200 PPP2R1B -0.97 -18.3 -0.71 4.49e-52 Primary sclerosing cholangitis; CRC cis rs10242455 0.571 rs13438288 chr7:98916414 T/G cg18809830 chr7:99032528 PTCD1 -0.93 -6.72 -0.35 8.13e-11 Blood metabolite levels; CRC cis rs4862750 0.914 rs11943333 chr4:187872455 A/G cg22105103 chr4:187893119 NA 0.63 11.26 0.53 4.31e-25 Lobe attachment (rater-scored or self-reported); CRC cis rs875971 0.862 rs6952182 chr7:65683317 T/G cg00343986 chr7:65444356 GUSB -0.47 -6.49 -0.34 3.11e-10 Aortic root size; CRC cis rs6582630 0.519 rs8189609 chr12:38281408 A/G cg13010199 chr12:38710504 ALG10B 0.45 5.75 0.3 2.07e-8 Drug-induced liver injury (flucloxacillin); CRC cis rs9296092 0.538 rs78061112 chr6:33526587 T/G cg13560919 chr6:33536144 NA -0.44 -6.28 -0.33 1.09e-9 Age at smoking initiation in chronic obstructive pulmonary disease; CRC cis rs6921919 0.525 rs16894095 chr6:28390230 C/T cg21251018 chr6:28226885 NKAPL 0.41 5.85 0.31 1.19e-8 Autism spectrum disorder or schizophrenia; CRC cis rs4727027 0.834 rs7811446 chr7:148773226 G/T cg12479418 chr7:148823350 ZNF425;ZNF398 0.45 6.13 0.32 2.54e-9 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC cis rs7932354 0.666 rs6485696 chr11:46842045 C/T cg19486271 chr11:47235900 DDB2 -0.47 -7.71 -0.39 1.5e-13 Bone mineral density (hip);Bone mineral density; CRC cis rs531930 1.000 rs486550 chr6:124738091 A/G cg22366943 chr6:124882293 NKAIN2 -0.43 -6.16 -0.32 2.09e-9 Celiac disease; CRC cis rs7264396 0.528 rs7273880 chr20:34551507 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.61 -9.83 -0.48 3.7799999999999997e-20 Total cholesterol levels; CRC cis rs3812762 0.783 rs11042070 chr11:8819367 C/T cg14711859 chr11:8959438 ASCL3 0.43 6.41 0.33 4.96e-10 Hypospadias; CRC cis rs2228479 0.850 rs62052711 chr16:89855100 C/A cg19635926 chr16:89946313 TCF25 0.63 5.61 0.3 4.35e-8 Skin colour saturation; CRC cis rs2294693 0.945 rs9349175 chr6:40982401 T/C cg14769373 chr6:40998127 UNC5CL -0.48 -6.18 -0.32 1.91e-9 Gastric cancer;Non-cardia gastric cancer; CRC cis rs2797160 1.000 rs6934435 chr6:126017481 T/G cg05901451 chr6:126070800 HEY2 0.39 6.03 0.32 4.46e-9 Endometrial cancer; CRC cis rs7618915 0.524 rs10433615 chr3:52638482 C/T cg08222913 chr3:52553049 STAB1 -0.34 -6.21 -0.32 1.64e-9 Bipolar disorder; CRC cis rs7552404 0.883 rs2185436 chr1:76203783 A/G cg22875332 chr1:76189707 ACADM 0.8 11.85 0.55 3.11e-27 Blood metabolite levels;Acylcarnitine levels; CRC cis rs1707322 1.000 rs4660906 chr1:46470860 C/T cg06784218 chr1:46089804 CCDC17 0.52 9.17 0.45 5.47e-18 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs17376456 1.000 rs12188453 chr5:93560807 G/T cg21475434 chr5:93447410 FAM172A -0.72 -6.86 -0.35 3.44e-11 Diabetic retinopathy; CRC cis rs9393692 0.905 rs9393693 chr6:26277408 C/A cg00631329 chr6:26305371 NA -0.68 -13.44 -0.6 3.92e-33 Educational attainment; CRC trans rs12940923 1.000 rs12451466 chr17:56378067 G/A cg16900910 chr15:72789182 ARIH1 0.54 6.08 0.32 3.25e-9 Circulating myeloperoxidase levels (plasma); CRC cis rs7605827 0.866 rs6745922 chr2:15537931 G/C cg19274914 chr2:15703543 NA 0.4 6.02 0.31 4.77e-9 Educational attainment (years of education); CRC cis rs7605827 0.930 rs6745731 chr2:15537915 C/T cg19274914 chr2:15703543 NA 0.4 6.0 0.31 5.17e-9 Educational attainment (years of education); CRC cis rs1670533 1.000 rs34956924 chr4:1047270 T/C cg27284194 chr4:1044797 NA 0.52 6.03 0.32 4.41e-9 Recombination rate (females); CRC cis rs1799949 1.000 rs4793191 chr17:41204377 A/G cg05368731 chr17:41323189 NBR1 0.68 10.3 0.49 9.6e-22 Menopause (age at onset); CRC cis rs561341 0.883 rs1034626 chr17:30219500 C/G cg13647721 chr17:30228624 UTP6 -0.54 -5.71 -0.3 2.49e-8 Hip circumference adjusted for BMI; CRC trans rs7267979 0.816 rs6076358 chr20:25519403 G/T cg17903999 chr18:56338584 MALT1 0.38 6.3 0.33 9.77e-10 Liver enzyme levels (alkaline phosphatase); CRC cis rs9430161 0.598 rs34350247 chr1:11034460 A/G cg02454025 chr1:11042201 C1orf127 0.97 16.17 0.67 1.12e-43 Ewing sarcoma; CRC cis rs875971 0.545 rs316324 chr7:65610614 A/G cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.6 -7.73 -0.39 1.29e-13 Aortic root size; CRC trans rs7824557 0.527 rs2572449 chr8:11239137 A/G cg06636001 chr8:8085503 FLJ10661 0.44 6.61 0.34 1.58e-10 Retinal vascular caliber; CRC cis rs7647973 0.848 rs4955411 chr3:49145304 A/G cg07636037 chr3:49044803 WDR6 0.84 10.35 0.5 6.46e-22 Menarche (age at onset); CRC cis rs7932354 0.710 rs2306032 chr11:46897253 G/C cg19486271 chr11:47235900 DDB2 -0.46 -7.38 -0.38 1.29e-12 Bone mineral density (hip);Bone mineral density; CRC cis rs11098499 0.818 rs10008791 chr4:120431469 A/C cg09307838 chr4:120376055 NA 0.68 10.32 0.49 8.02e-22 Corneal astigmatism; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg12655729 chr3:194393122 LSG1 0.54 7.0 0.36 1.41e-11 Thyroid stimulating hormone; CRC cis rs12760731 0.623 rs2300300 chr1:178419387 G/C cg00404053 chr1:178313656 RASAL2 0.78 9.09 0.45 9.39e-18 Obesity-related traits; CRC cis rs6951245 0.935 rs112554101 chr7:1065535 A/G cg21664854 chr7:1097933 C7orf50;GPR146 0.62 7.69 0.39 1.71e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs9640161 0.789 rs2098053 chr7:150043205 G/A cg12556325 chr7:150026731 C7orf29;LRRC61 -0.47 -6.78 -0.35 5.63e-11 Blood protein levels;Circulating chemerin levels; CRC cis rs2075371 1.000 rs2598292 chr7:133988584 C/G cg20476274 chr7:133979776 SLC35B4 0.82 15.11 0.64 1.57e-39 Mean platelet volume; CRC cis rs6504622 0.934 rs3760377 chr17:45042079 G/A cg16759221 chr17:45003025 GOSR2 0.47 7.46 0.38 7.87e-13 Orofacial clefts; CRC cis rs9649213 0.614 rs9641236 chr7:97998124 T/A cg09267113 chr7:98030324 BAIAP2L1 -0.92 -11.69 -0.54 1.19e-26 Prostate cancer (SNP x SNP interaction); CRC cis rs10832963 1.000 rs10832962 chr11:18656271 C/T cg09201001 chr11:18656081 SPTY2D1 0.79 12.29 0.56 7.87e-29 Breast cancer; CRC trans rs9858542 0.953 rs9841110 chr3:49492481 C/G cg21665057 chr3:196295764 WDR53;FBXO45 -0.65 -8.86 -0.44 5.12e-17 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs7705042 0.826 rs11749731 chr5:141500436 A/C cg08523384 chr5:141488047 NDFIP1 -0.34 -5.98 -0.31 5.83e-9 Asthma; CRC cis rs2075371 0.673 rs35290398 chr7:134011773 C/T cg20476274 chr7:133979776 SLC35B4 0.61 9.27 0.45 2.61e-18 Mean platelet volume; CRC cis rs10411161 0.702 rs6509592 chr19:52393150 G/A cg09547119 chr19:52391367 ZNF577 0.48 5.85 0.31 1.2e-8 Breast cancer; CRC cis rs1707322 0.752 rs11211168 chr1:46163647 C/T cg03146154 chr1:46216737 IPP 0.66 9.61 0.47 1.95e-19 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs7923609 0.846 rs7075901 chr10:65280994 C/A cg08743896 chr10:65200160 JMJD1C -0.42 -5.95 -0.31 6.97e-9 Educational attainment;Liver enzyme levels (alkaline phosphatase); CRC cis rs12580194 0.593 rs55898514 chr12:55736238 G/A cg23425280 chr12:56401806 NA 0.47 6.02 0.32 4.57e-9 Cancer; CRC cis rs8177179 0.505 rs1405023 chr3:133481128 T/C cg16262614 chr3:133464971 TF -0.33 -5.77 -0.3 1.87e-8 Iron status biomarkers (transferrin levels); CRC cis rs7208859 0.623 rs11658945 chr17:29122509 T/C cg13385521 chr17:29058706 SUZ12P 0.73 8.38 0.42 1.53e-15 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs7618915 0.524 rs12488461 chr3:52698417 T/C cg08222913 chr3:52553049 STAB1 -0.34 -6.12 -0.32 2.7e-9 Bipolar disorder; CRC trans rs12478296 0.901 rs67951957 chr2:243004901 A/G cg06834434 chr14:75079333 LTBP2 0.55 6.62 0.34 1.47e-10 Obesity-related traits; CRC cis rs6964587 1.000 rs9784993 chr7:91672403 G/A cg17063962 chr7:91808500 NA 0.8 14.21 0.62 4.48e-36 Breast cancer; CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg05790982 chr4:4861404 MSX1 0.37 5.98 0.31 5.72e-9 Obesity-related traits; CRC trans rs2797160 1.000 rs2747725 chr6:126012397 A/C cg05039488 chr6:79577232 IRAK1BP1 0.44 6.33 0.33 8.13e-10 Endometrial cancer; CRC cis rs12681288 0.644 rs2123058 chr8:1000304 A/G cg15309053 chr8:964076 NA 0.42 7.02 0.36 1.26e-11 Schizophrenia; CRC cis rs2425143 0.841 rs4911519 chr20:34362326 A/T cg04508476 chr20:34239394 CPNE1;RBM12 0.48 6.08 0.32 3.36e-9 Blood protein levels; CRC cis rs7528419 1.000 rs12740374 chr1:109817590 G/T cg17243654 chr1:109816280 CELSR2 -0.43 -5.81 -0.3 1.5e-8 Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease);Myocardial infarction;Lipoprotein-associated phospholipase A2 activity and mass;Lipoprotein-associated phospholipase A2 activity change in response to darapladib treatment in cardiovascular disease;Cholesterol, total;Coronary artery disease; CRC cis rs863345 0.604 rs7525362 chr1:158493890 G/C cg12129480 chr1:158549410 OR10X1 -0.29 -5.95 -0.31 7e-9 Pneumococcal bacteremia; CRC cis rs10463316 0.894 rs6875014 chr5:150754345 C/T cg03212797 chr5:150827313 SLC36A1 -0.48 -7.72 -0.39 1.45e-13 Metabolite levels (Pyroglutamine); CRC cis rs752010 0.746 rs10749837 chr1:42089471 T/C cg06885757 chr1:42089581 HIVEP3 0.5 9.14 0.45 6.38e-18 Lupus nephritis in systemic lupus erythematosus; CRC cis rs62244186 0.711 rs6778410 chr3:44743993 C/T cg15604051 chr3:44754201 ZNF502 -0.36 -5.69 -0.3 2.8e-8 Depressive symptoms; CRC trans rs820077 0.557 rs4713840 chr6:35143168 C/T cg23173586 chr14:20945319 PNP -0.29 -6.03 -0.32 4.43e-9 Systemic lupus erythematosus; CRC trans rs208520 0.690 rs12213581 chr6:66735818 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 1.05 14.74 0.63 4.18e-38 Exhaled nitric oxide output; CRC cis rs7487075 0.897 rs7979418 chr12:46774771 A/G cg22049899 chr12:47219821 SLC38A4 0.32 5.94 0.31 7.14e-9 Itch intensity from mosquito bite; CRC cis rs13082711 0.863 rs66743193 chr3:27471958 G/A cg02860705 chr3:27208620 NA 0.61 8.19 0.41 5.84e-15 Systolic blood pressure;Diastolic blood pressure;Blood pressure; CRC cis rs3736485 0.966 rs7174435 chr15:51895065 G/A cg08986416 chr15:51914746 DMXL2 -0.48 -6.74 -0.35 7.06e-11 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs6952808 0.825 rs12669937 chr7:1939765 C/T cg20295408 chr7:1910781 MAD1L1 -0.42 -5.87 -0.31 1.04e-8 Bipolar disorder and schizophrenia; CRC cis rs6921919 0.697 rs6942030 chr6:28315958 A/T cg03623178 chr6:28175578 NA 0.45 6.09 0.32 3.07e-9 Autism spectrum disorder or schizophrenia; CRC cis rs736408 0.608 rs2239547 chr3:52855229 T/C cg18404041 chr3:52824283 ITIH1 -0.4 -7.48 -0.38 6.74e-13 Bipolar disorder; CRC cis rs1506636 1.000 rs7357252 chr7:123369856 C/T cg03229431 chr7:123269106 ASB15 -0.74 -11.75 -0.54 7.63e-27 Plateletcrit;Platelet count; CRC cis rs6459804 0.844 rs76501205 chr7:157508941 A/T cg05731713 chr7:157510257 PTPRN2 0.47 7.8 0.4 8.33e-14 Bipolar disorder and schizophrenia; CRC cis rs12594515 1.000 rs6493168 chr15:45986811 A/C cg01629716 chr15:45996671 NA 0.41 8.5 0.42 6.75e-16 Waist circumference;Weight; CRC trans rs6472827 0.645 rs2977070 chr8:75112770 A/G cg16732884 chr16:2569654 AMDHD2;ATP6V0C -0.39 -6.07 -0.32 3.62e-9 Uterine fibroids; CRC cis rs7493 1.000 rs7493 chr7:95034775 C/G cg19678392 chr7:94953810 PON1 0.56 7.05 0.36 1.07e-11 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs17253792 0.915 rs28375514 chr14:56179941 G/A cg01858014 chr14:56050164 KTN1 -0.79 -6.09 -0.32 3.09e-9 Putamen volume; CRC cis rs3858526 0.920 rs10742832 chr11:5926020 C/G cg13902645 chr11:5959945 NA -0.6 -8.23 -0.41 4.37e-15 DNA methylation (variation); CRC cis rs8014204 0.870 rs3742790 chr14:75308758 C/T cg03030879 chr14:75389066 RPS6KL1 0.5 8.04 0.41 1.68e-14 Caffeine consumption; CRC cis rs4237845 0.837 rs7954591 chr12:58299037 A/G cg00677455 chr12:58241039 CTDSP2 0.52 7.55 0.38 4.24e-13 Intelligence (multi-trait analysis); CRC cis rs7223966 1.000 rs9901507 chr17:61765524 G/A cg23903597 chr17:61704154 MAP3K3 -0.42 -5.81 -0.3 1.51e-8 Hip circumference adjusted for BMI;Body mass index; CRC cis rs6598955 0.671 rs7544 chr1:26607726 T/G cg04990556 chr1:26633338 UBXN11 0.53 5.73 0.3 2.23e-8 Obesity-related traits; CRC cis rs2404602 0.618 rs12442266 chr15:76567142 T/C cg22467129 chr15:76604101 ETFA -0.47 -8.35 -0.42 1.89e-15 Blood metabolite levels; CRC cis rs4843747 0.671 rs28465438 chr16:88103714 G/A cg17633681 chr16:88106987 BANP 0.88 15.38 0.65 1.3e-40 Menopause (age at onset); CRC cis rs9649213 0.574 rs34830366 chr7:97899535 G/T cg21770322 chr7:97807741 LMTK2 0.56 9.32 0.46 1.72e-18 Prostate cancer (SNP x SNP interaction); CRC cis rs7772486 0.727 rs11155442 chr6:146140725 T/C cg23711669 chr6:146136114 FBXO30 0.73 12.61 0.57 5.41e-30 Lobe attachment (rater-scored or self-reported); CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg19424343 chr3:16306684 OXNAD1;DPH3 0.47 6.77 0.35 5.84e-11 Anxiety disorder; CRC cis rs9611565 0.659 rs12484175 chr22:41953739 A/C cg06634786 chr22:41940651 POLR3H -0.66 -7.73 -0.39 1.31e-13 Vitiligo; CRC trans rs8002861 0.619 rs1337203 chr13:44423621 T/G cg12856521 chr11:46389249 DGKZ 0.44 7.21 0.37 3.98e-12 Leprosy; CRC cis rs9322193 0.923 rs12175504 chr6:149985215 T/G cg13206674 chr6:150067644 NUP43 0.57 8.14 0.41 8.11e-15 Lung cancer; CRC cis rs798766 0.723 rs3134865 chr4:1723279 T/C cg02089348 chr4:1724449 TMEM129;TACC3 -0.4 -5.76 -0.3 1.91e-8 Bladder cancer;Urinary bladder cancer; CRC cis rs11190604 0.943 rs7085261 chr10:102209811 G/A cg16342193 chr10:102329863 NA -0.35 -5.83 -0.31 1.29e-8 Palmitoleic acid (16:1n-7) levels; CRC cis rs3736594 0.513 rs62138965 chr2:27816593 T/C cg27432699 chr2:27873401 GPN1 0.65 8.0 0.4 2.1e-14 Fasting blood glucose;Fasting blood glucose (BMI interaction); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg08593074 chr19:55678419 C19orf51 0.44 6.37 0.33 6.39e-10 Response to antipsychotic treatment; CRC trans rs1005277 0.522 rs1208684 chr10:38093936 G/A cg27523141 chr10:43048294 ZNF37B 0.44 6.42 0.33 4.7e-10 Extrinsic epigenetic age acceleration; CRC cis rs6062302 0.522 rs4809312 chr20:62234240 C/T cg16989086 chr20:62203971 PRIC285 0.51 6.41 0.33 5.08e-10 Glioblastoma; CRC cis rs2832191 0.791 rs7282843 chr21:30475226 A/G cg24692254 chr21:30365293 RNF160 0.71 12.56 0.57 7.83e-30 Dental caries; CRC cis rs875971 0.545 rs3936065 chr7:65790564 C/T cg18876405 chr7:65276391 NA 0.46 6.45 0.34 3.96e-10 Aortic root size; CRC cis rs951366 0.789 rs823137 chr1:205738302 C/T cg17178900 chr1:205818956 PM20D1 0.67 9.82 0.48 3.97e-20 Menarche (age at onset); CRC cis rs17065868 0.764 rs73188711 chr13:45015814 A/G cg10246903 chr13:45222710 NA 0.58 5.65 0.3 3.45e-8 Antineutrophil cytoplasmic antibody-associated vasculitis; CRC cis rs78456975 1.000 rs7584264 chr2:1565555 A/G cg12573674 chr2:1569213 NA -0.73 -8.07 -0.41 1.38e-14 Placebo response in major depressive disorder (% change in symptom score); CRC cis rs11098499 0.775 rs2002049 chr4:120257417 A/G cg24375607 chr4:120327624 NA 0.47 7.45 0.38 8.16e-13 Corneal astigmatism; CRC cis rs540254 0.551 rs2271967 chr1:160787705 T/C cg20255094 chr1:160771763 LY9 0.48 6.31 0.33 9.12e-10 Blood protein levels; CRC cis rs73206853 0.563 rs7301769 chr12:111171026 T/C cg12870014 chr12:110450643 ANKRD13A 0.75 8.89 0.44 4.07e-17 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC cis rs877282 0.898 rs12356709 chr10:763365 A/G cg17470449 chr10:769945 NA 0.65 8.51 0.42 6.25e-16 Uric acid levels; CRC cis rs2228479 0.850 rs2190808 chr16:89840856 C/T cg06558623 chr16:89946397 TCF25 1.09 10.23 0.49 1.69e-21 Skin colour saturation; CRC cis rs3733585 0.673 rs7376505 chr4:9952744 C/A cg11266682 chr4:10021025 SLC2A9 -0.47 -9.62 -0.47 1.76e-19 Cleft plate (environmental tobacco smoke interaction); CRC cis rs752010 0.714 rs2182606 chr1:42082375 T/C cg06885757 chr1:42089581 HIVEP3 0.47 8.52 0.43 5.75e-16 Lupus nephritis in systemic lupus erythematosus; CRC cis rs2243480 1.000 rs313799 chr7:65494330 A/G cg12463550 chr7:65579703 CRCP 0.69 6.35 0.33 7.16e-10 Diabetic kidney disease; CRC cis rs7927771 0.839 rs11039308 chr11:47622412 G/A cg05585544 chr11:47624801 NA -0.46 -8.26 -0.41 3.69e-15 Subjective well-being; CRC cis rs9549260 0.591 rs9577115 chr13:41276553 T/C cg21288729 chr13:41239152 FOXO1 0.43 6.76 0.35 6.47e-11 Red blood cell count; CRC cis rs826838 0.967 rs1719858 chr12:39124505 C/T cg13010199 chr12:38710504 ALG10B -0.39 -5.67 -0.3 3.06e-8 Heart rate; CRC cis rs924607 0.900 rs1697950 chr5:616890 G/A cg09021430 chr5:549028 NA 0.51 8.57 0.43 4.2e-16 Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia; CRC trans rs10411161 0.702 rs8113584 chr19:52383874 A/G cg22319618 chr22:45562946 NUP50 -0.68 -7.53 -0.38 4.85e-13 Breast cancer; CRC cis rs780096 0.526 rs4803 chr2:27667297 A/G cg02592271 chr2:27665507 KRTCAP3 -0.29 -6.69 -0.35 9.47e-11 Total body bone mineral density; CRC cis rs62244186 1.000 rs62244186 chr3:44739783 G/A cg11003573 chr3:44754125 ZNF502 -0.37 -6.38 -0.33 6.1e-10 Depressive symptoms; CRC cis rs2153535 0.580 rs1335643 chr6:8488021 T/G cg07606381 chr6:8435919 SLC35B3 0.68 10.89 0.51 8.84e-24 Motion sickness; CRC cis rs7769051 1.000 rs9493446 chr6:133125643 C/T cg22852734 chr6:133119734 C6orf192 0.98 12.25 0.56 1.12e-28 Type 2 diabetes nephropathy; CRC cis rs4727027 0.899 rs6464942 chr7:148826368 T/C cg23583168 chr7:148888333 NA -0.89 -15.24 -0.64 4.88e-40 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC cis rs2675662 0.525 rs12264025 chr10:75494450 A/G cg16540259 chr10:75572220 NDST2 0.38 5.91 0.31 8.5e-9 Psoriasis vulgaris;Psoriasis; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg00098451 chr1:16370634 CLCNKB -0.41 -6.67 -0.35 1.05e-10 Liver disease severity in Alagille syndrome; CRC cis rs9903692 0.505 rs208008 chr17:46230838 C/T cg10706073 chr17:46328419 SKAP1 0.59 6.37 0.33 6.25e-10 Pulse pressure; CRC cis rs9733 0.596 rs72702552 chr1:150677462 G/A cg15448220 chr1:150897856 SETDB1 0.46 6.53 0.34 2.55e-10 Tonsillectomy; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg02702510 chr10:46090551 MARCH8 0.46 6.6 0.34 1.67e-10 Intelligence (multi-trait analysis); CRC cis rs9611565 0.729 rs2413647 chr22:41907148 G/A cg17554472 chr22:41940697 POLR3H -0.54 -5.75 -0.3 2.09e-8 Vitiligo; CRC cis rs514406 0.584 rs11205997 chr1:53195271 G/C cg08859206 chr1:53392774 SCP2 0.42 6.46 0.34 3.7e-10 Monocyte count; CRC cis rs9467773 0.649 rs2145318 chr6:26496603 T/A cg09904177 chr6:26538194 HMGN4 0.7 10.8 0.51 1.76e-23 Intelligence (multi-trait analysis); CRC cis rs1865760 0.533 rs1408270 chr6:25873184 A/G cg17691542 chr6:26056736 HIST1H1C 0.7 9.2 0.45 4.13e-18 Height; CRC cis rs4727027 0.899 rs7791496 chr7:148863674 C/G cg23583168 chr7:148888333 NA -0.92 -16.19 -0.67 9.15e-44 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC cis rs7615952 0.599 rs12486459 chr3:125741465 T/G cg06494592 chr3:125709126 NA -0.55 -6.43 -0.33 4.43e-10 Blood pressure (smoking interaction); CRC cis rs7209700 0.962 rs56327427 chr17:45354746 C/T cg17185639 chr17:45330862 ITGB3 0.35 5.94 0.31 7.37e-9 IgG glycosylation; CRC cis rs2019137 0.967 rs902695 chr2:113955074 G/A cg19083407 chr2:113993142 PAX8;LOC440839;LOC654433 -0.46 -6.44 -0.33 4.21e-10 Lymphocyte counts; CRC cis rs2976388 0.934 rs2920279 chr8:143762135 A/C cg24046110 chr8:143859143 LYNX1 -0.36 -6.13 -0.32 2.54e-9 Urinary tract infection frequency; CRC cis rs1552244 0.572 rs59132826 chr3:10169725 G/A cg18598329 chr3:10140678 FANCD2;C3orf24 -0.9 -10.73 -0.51 3.19e-23 Alzheimer's disease; CRC cis rs9611565 0.694 rs5758324 chr22:41787950 G/T cg06634786 chr22:41940651 POLR3H -0.46 -6.01 -0.31 4.93e-9 Vitiligo; CRC cis rs9517320 0.515 rs4771307 chr13:99221879 A/G cg20487152 chr13:99095054 FARP1 -0.44 -6.26 -0.33 1.17e-9 Longevity; CRC cis rs4803468 1.000 rs10422956 chr19:41901261 C/T cg09537434 chr19:41945824 ATP5SL -0.97 -18.7 -0.72 1.17e-53 Height; CRC cis rs11931598 0.511 rs4689576 chr4:7025523 T/C cg26116260 chr4:7069785 GRPEL1 0.39 5.86 0.31 1.14e-8 Sum basophil neutrophil counts;Sum neutrophil eosinophil counts;Granulocyte count;Neutrophil count;Myeloid white cell count; CRC cis rs11190604 1.000 rs11190557 chr10:102209369 G/A cg16342193 chr10:102329863 NA -0.35 -5.88 -0.31 1.03e-8 Palmitoleic acid (16:1n-7) levels; CRC cis rs4253772 0.591 rs73886791 chr22:46687212 A/G cg03482458 chr22:46692211 CN5H6.4;GTSE1 0.58 8.31 0.42 2.52e-15 LDL cholesterol;Cholesterol, total; CRC trans rs9858542 0.953 rs7646366 chr3:49470668 G/A cg21582582 chr3:182698605 DCUN1D1 -0.51 -6.45 -0.34 4.03e-10 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs4285028 0.747 rs12634032 chr3:121524575 G/A cg20356878 chr3:121714668 ILDR1 -0.51 -6.59 -0.34 1.73e-10 Multiple sclerosis; CRC cis rs763121 0.819 rs4560233 chr22:38982442 A/T cg06022373 chr22:39101656 GTPBP1 0.74 11.16 0.52 9.92e-25 Menopause (age at onset); CRC cis rs77861329 1.000 rs28452586 chr3:52176007 A/G cg08692210 chr3:52188851 WDR51A 0.85 8.31 0.42 2.62e-15 Macrophage inflammatory protein 1b levels; CRC cis rs11168351 0.864 rs10875743 chr12:48498413 C/T cg21466736 chr12:48725269 NA 0.47 7.25 0.37 3.03e-12 Bipolar disorder and schizophrenia; CRC cis rs3796619 1.000 rs11247973 chr4:1094314 G/A cg27284194 chr4:1044797 NA 0.4 6.16 0.32 2.09e-9 Recombination rate (males); CRC cis rs7772486 0.686 rs4896833 chr6:145965673 T/G cg05347473 chr6:146136440 FBXO30 0.37 5.67 0.3 3.08e-8 Lobe attachment (rater-scored or self-reported); CRC cis rs11098499 0.738 rs34965784 chr4:120361586 G/C cg09307838 chr4:120376055 NA 0.72 11.22 0.53 5.85e-25 Corneal astigmatism; CRC cis rs10504229 0.953 rs114853497 chr8:58176176 A/T cg01721255 chr8:58191610 C8orf71 0.49 6.17 0.32 2e-9 Developmental language disorder (linguistic errors); CRC cis rs898097 0.627 rs3785514 chr17:80888905 A/G cg19046167 chr17:80928561 B3GNTL1 0.39 5.86 0.31 1.14e-8 Breast cancer; CRC cis rs7178572 0.568 rs1125617 chr15:77532711 A/G cg22256960 chr15:77711686 NA -0.67 -9.72 -0.47 8.52e-20 Type 2 diabetes; CRC cis rs853679 0.607 rs201002 chr6:27808192 A/G cg19041857 chr6:27730383 NA -0.72 -7.05 -0.36 1.07e-11 Depression; CRC cis rs1953600 1.000 rs2573346 chr10:81918041 G/A cg00277334 chr10:82204260 NA -0.37 -5.95 -0.31 6.79e-9 Sarcoidosis; CRC cis rs7017697 1.000 rs7017697 chr8:19685909 G/T cg03894339 chr8:19674705 INTS10 -0.42 -5.77 -0.3 1.85e-8 Breast cancer; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg17424859 chr6:71319002 NA 0.45 6.63 0.34 1.39e-10 Myopia (pathological); CRC cis rs12523822 0.826 rs866993 chr6:154969004 G/A cg20019720 chr6:154832845 CNKSR3 0.28 5.95 0.31 6.91e-9 Diabetic kidney disease; CRC cis rs1322512 1.000 rs2800623 chr6:153003720 A/G cg03415253 chr6:152958462 SYNE1 0.44 6.85 0.35 3.74e-11 Tonometry; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg07284132 chr22:36462314 NA 0.42 6.1 0.32 3.01e-9 Response to antipsychotic treatment; CRC trans rs712068 0.935 rs10916640 chr1:224747597 C/G cg04390004 chr19:39279324 LGALS7B 0.42 6.3 0.33 9.78e-10 Cancer; CRC cis rs9322193 0.923 rs9767105 chr6:149980727 A/G cg07701084 chr6:150067640 NUP43 0.6 9.0 0.44 1.79e-17 Lung cancer; CRC cis rs3087591 1.000 rs2854331 chr17:29711728 G/A cg24425628 chr17:29625626 OMG;NF1 -0.81 -14.87 -0.63 1.3e-38 Hip circumference; CRC cis rs826838 0.935 rs11168761 chr12:38997211 C/A cg13010199 chr12:38710504 ALG10B 0.44 5.8 0.3 1.52e-8 Heart rate; CRC cis rs12545109 0.800 rs1348082 chr8:57415016 A/G cg09654669 chr8:57350985 NA -0.45 -7.22 -0.37 3.56e-12 Obesity-related traits; CRC cis rs1707322 0.752 rs6678444 chr1:46229847 A/G cg06784218 chr1:46089804 CCDC17 0.65 12.11 0.56 3.76e-28 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs9388451 0.903 rs9388446 chr6:126064920 T/A cg05901451 chr6:126070800 HEY2 -0.67 -11.63 -0.54 1.99e-26 Brugada syndrome; CRC cis rs1568889 0.838 rs10835299 chr11:28277693 A/G cg06544937 chr11:28130018 METT5D1;KIF18A -0.93 -15.84 -0.66 2.13e-42 Bipolar disorder; CRC cis rs6952808 0.771 rs10950415 chr7:1914477 A/G cg22963979 chr7:1858916 MAD1L1 -0.47 -7.5 -0.38 6.08e-13 Bipolar disorder and schizophrenia; CRC cis rs6502050 0.777 rs11077969 chr17:80085633 A/G cg19223190 chr17:80058835 NA -0.39 -6.24 -0.33 1.31e-9 Life satisfaction; CRC cis rs896854 0.654 rs896847 chr8:95972551 G/A cg23172400 chr8:95962367 TP53INP1 -0.48 -8.19 -0.41 5.98e-15 Type 2 diabetes; CRC cis rs875971 0.545 rs73148639 chr7:65855329 A/T cg05627663 chr7:65219948 SNORA22;CCT6P1 0.57 7.4 0.38 1.14e-12 Aortic root size; CRC cis rs887829 0.694 rs6749496 chr2:234624286 T/C cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.54 -8.65 -0.43 2.3e-16 Metabolic traits;Bilirubin levels;Cholelithiasis-related traits in sickle cell anemia;Metabolite levels;Total bilirubin levels in HIV-1 infection;Serum metabolite levels;Blood metabolite levels; CRC cis rs12464559 0.522 rs11676866 chr2:152628858 G/C cg01189475 chr2:152685088 ARL5A 0.51 5.72 0.3 2.44e-8 Response to cognitive-behavioural therapy in anxiety disorder; CRC cis rs6456156 0.774 rs6931530 chr6:167527200 A/C cg07513332 chr6:167530253 CCR6 -0.45 -8.36 -0.42 1.79e-15 Primary biliary cholangitis; CRC trans rs1569175 1.000 rs1509830 chr2:200908143 G/A cg12143499 chr12:27615389 NA 0.68 6.15 0.32 2.25e-9 Response to treatment for acute lymphoblastic leukemia; CRC cis rs270601 0.739 rs3900945 chr5:131592870 T/C cg20512303 chr5:131592959 PDLIM4 0.42 7.82 0.4 7.04e-14 Acylcarnitine levels; CRC cis rs3750082 0.855 rs6462430 chr7:32921831 G/A cg05721444 chr7:32995514 FKBP9 0.5 7.76 0.39 1.12e-13 Glomerular filtration rate (creatinine); CRC cis rs7107174 0.711 rs66583694 chr11:78037773 C/T cg02023728 chr11:77925099 USP35 0.48 8.69 0.43 1.75e-16 Testicular germ cell tumor; CRC cis rs7666738 0.830 rs7662218 chr4:98983126 T/G cg17366294 chr4:99064904 C4orf37 0.43 7.14 0.37 5.92e-12 Colonoscopy-negative controls vs population controls; CRC cis rs929354 0.685 rs1808217 chr7:157002741 T/C cg17757837 chr7:157058334 UBE3C 0.74 12.62 0.57 4.92e-30 Body mass index; CRC cis rs7584330 0.744 rs10929235 chr2:238380272 A/G cg11271282 chr2:238384023 NA 0.48 5.72 0.3 2.36e-8 Prostate cancer; CRC cis rs853679 0.546 rs483143 chr6:27846744 G/C cg08798685 chr6:27730294 NA -0.59 -5.61 -0.3 4.26e-8 Depression; CRC cis rs4654899 0.571 rs6692677 chr1:21251717 C/T cg02927042 chr1:21476669 EIF4G3 -0.38 -6.01 -0.31 4.8e-9 Superior frontal gyrus grey matter volume; CRC trans rs3931020 0.720 rs927904 chr1:75260328 A/G cg15496871 chr19:36208495 MLL4 0.51 6.59 0.34 1.74e-10 Resistin levels; CRC cis rs826838 0.834 rs2387842 chr12:38736442 T/C cg26384229 chr12:38710491 ALG10B 0.77 10.67 0.51 5.18e-23 Heart rate; CRC cis rs2013441 1.000 rs2526467 chr17:20165054 T/A cg13482628 chr17:19912719 NA -0.4 -6.18 -0.32 1.92e-9 Obesity-related traits; CRC cis rs4268898 0.552 rs12621083 chr2:24367540 C/T cg06627628 chr2:24431161 ITSN2 0.45 6.87 0.35 3.14e-11 Asthma; CRC cis rs4713118 0.513 rs149958 chr6:28013617 A/C cg12172441 chr6:28176163 NA 0.5 6.73 0.35 7.38e-11 Parkinson's disease; CRC cis rs7605827 0.930 rs13410044 chr2:15602535 A/G cg19274914 chr2:15703543 NA 0.4 6.04 0.32 4.18e-9 Educational attainment (years of education); CRC cis rs4853036 0.859 rs10196546 chr2:70157158 T/C cg02498382 chr2:70120550 SNRNP27 -0.5 -7.54 -0.38 4.53e-13 Colorectal or endometrial cancer; CRC trans rs2014572 0.967 rs8106734 chr19:57763546 C/T cg02674126 chr19:40336878 FBL 0.42 6.67 0.35 1.09e-10 Hyperactive-impulsive symptoms; CRC cis rs4285028 0.747 rs9852845 chr3:121390618 A/C cg20356878 chr3:121714668 ILDR1 -0.43 -6.09 -0.32 3.08e-9 Multiple sclerosis; CRC cis rs9649213 0.574 rs36099592 chr7:98002331 T/C cg21770322 chr7:97807741 LMTK2 0.53 8.62 0.43 2.78e-16 Prostate cancer (SNP x SNP interaction); CRC trans rs9914544 0.545 rs8077775 chr17:18809543 A/G cg21372672 chr17:16614065 CCDC144A -0.4 -6.35 -0.33 6.98e-10 Educational attainment (years of education); CRC cis rs17376456 0.569 rs1349711 chr5:93179032 C/T cg25358565 chr5:93447407 FAM172A -0.66 -8.02 -0.4 1.9e-14 Diabetic retinopathy; CRC cis rs28386778 0.897 rs2727290 chr17:61894728 G/T cg06873352 chr17:61820015 STRADA 0.77 14.46 0.62 5e-37 Prudent dietary pattern; CRC cis rs950169 0.922 rs4842946 chr15:84942331 G/A cg17507749 chr15:85114479 UBE2QP1 0.74 10.59 0.5 9.91e-23 Schizophrenia; CRC cis rs311392 0.902 rs411371 chr8:55092609 G/A cg20636351 chr8:55087400 NA -0.33 -5.96 -0.31 6.62e-9 Pelvic organ prolapse (moderate/severe); CRC cis rs72781680 1.000 rs72798417 chr2:24188656 C/T cg08917208 chr2:24149416 ATAD2B 0.91 9.28 0.46 2.29e-18 Lymphocyte counts; CRC cis rs1865760 0.613 rs2071300 chr6:25914572 C/T cg17691542 chr6:26056736 HIST1H1C 0.44 6.72 0.35 8.1e-11 Height; CRC cis rs2795502 0.515 rs116848302 chr10:43367783 G/A cg15903213 chr10:43522190 NA -0.7 -5.63 -0.3 3.83e-8 Blood protein levels; CRC cis rs11212617 0.967 rs4237579 chr11:108279201 A/G cg12106634 chr11:108092400 ATM;NPAT 0.43 6.52 0.34 2.61e-10 Response to metformin in type 2 diabetes (glycemic); CRC cis rs4819052 0.851 rs13050359 chr21:46672671 T/G cg19498844 chr21:46707878 POFUT2;LOC642852 0.75 10.99 0.52 3.71e-24 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs8067545 0.750 rs4925079 chr17:19986861 T/A cg13482628 chr17:19912719 NA 0.48 7.72 0.39 1.44e-13 Schizophrenia; CRC cis rs7769051 0.521 rs9321367 chr6:133084359 G/T cg22852734 chr6:133119734 C6orf192 0.8 7.16 0.37 5.39e-12 Type 2 diabetes nephropathy; CRC cis rs875971 0.862 rs1695820 chr7:65844563 G/A cg11764359 chr7:65958608 NA 0.59 9.08 0.45 1.06e-17 Aortic root size; CRC cis rs7772486 0.754 rs4566902 chr6:146244128 A/G cg13319975 chr6:146136371 FBXO30 0.41 6.15 0.32 2.25e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs7762018 1.000 rs6923339 chr6:170128033 T/A cg19338460 chr6:170058176 WDR27 -0.67 -7.38 -0.38 1.32e-12 Thiazide-induced adverse metabolic effects in hypertensive patients; CRC cis rs73206853 0.841 rs11065663 chr12:110988886 G/T cg12870014 chr12:110450643 ANKRD13A 0.66 7.95 0.4 2.96e-14 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg04718306 chr1:68151105 GADD45A 0.46 6.1 0.32 2.94e-9 Anxiety disorder; CRC cis rs7208859 0.673 rs55904046 chr17:29215391 G/A cg14008862 chr17:28927542 LRRC37B2 0.54 5.68 0.3 2.91e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs7584330 0.518 rs77789507 chr2:238440972 C/T cg08992911 chr2:238395768 MLPH 0.59 5.91 0.31 8.33e-9 Prostate cancer; CRC cis rs6921919 0.697 rs12180820 chr6:28316478 A/G cg06470822 chr6:28175283 NA -0.46 -6.35 -0.33 7.28e-10 Autism spectrum disorder or schizophrenia; CRC cis rs6502050 0.835 rs67682841 chr17:80117745 T/C cg25804541 chr17:80189381 SLC16A3 -0.31 -5.98 -0.31 5.73e-9 Life satisfaction; CRC cis rs208520 0.526 rs7775830 chr6:66755249 A/G cg07460842 chr6:66804631 NA 1.11 21.04 0.76 7.33e-63 Exhaled nitric oxide output; CRC cis rs1862618 0.802 rs986049 chr5:56110233 G/A cg03609598 chr5:56110824 MAP3K1 -0.84 -10.38 -0.5 4.97e-22 Initial pursuit acceleration; CRC cis rs2075371 1.000 rs2244700 chr7:133987374 A/G cg02659138 chr7:134003124 SLC35B4 0.4 7.09 0.36 8.32e-12 Mean platelet volume; CRC cis rs9549260 0.620 rs9532580 chr13:41244260 T/C cg21288729 chr13:41239152 FOXO1 0.5 6.71 0.35 8.35e-11 Red blood cell count; CRC cis rs514406 0.929 rs12354395 chr1:53327663 A/G cg08859206 chr1:53392774 SCP2 -0.45 -7.04 -0.36 1.16e-11 Monocyte count; CRC cis rs7584330 0.666 rs7600317 chr2:238353513 C/T cg16989719 chr2:238392110 NA -0.38 -6.87 -0.35 3.19e-11 Prostate cancer; CRC cis rs4853036 0.951 rs3755391 chr2:70141519 C/T cg02498382 chr2:70120550 SNRNP27 -0.43 -6.17 -0.32 2.04e-9 Colorectal or endometrial cancer; CRC cis rs3857536 0.730 rs7761295 chr6:66932532 G/A cg07460842 chr6:66804631 NA -0.42 -5.7 -0.3 2.64e-8 Blood trace element (Cu levels); CRC cis rs4964805 0.683 rs12424737 chr12:104196221 A/C cg02344784 chr12:104178138 NT5DC3 0.79 14.62 0.63 1.17e-37 Attention deficit hyperactivity disorder; CRC cis rs763014 0.932 rs34498660 chr16:666149 A/G cg07343612 chr16:622815 PIGQ -0.82 -14.04 -0.61 2.03e-35 Height; CRC cis rs7208859 0.623 rs56095789 chr17:29060170 A/G cg13385521 chr17:29058706 SUZ12P 0.7 7.85 0.4 5.96e-14 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs7737355 1.000 rs11242077 chr5:130771037 G/A cg06307176 chr5:131281290 NA -0.46 -6.68 -0.35 9.95e-11 Life satisfaction; CRC cis rs6860806 0.507 rs272880 chr5:131670178 C/T cg04518342 chr5:131593106 PDLIM4 0.43 7.01 0.36 1.33e-11 Breast cancer; CRC cis rs7527798 0.592 rs1323720 chr1:207823161 T/C cg09232269 chr1:207846808 CR1L -0.46 -7.45 -0.38 8.05e-13 Erythrocyte sedimentation rate; CRC trans rs7618501 0.540 rs11130241 chr3:50131459 A/T cg21659725 chr3:3221576 CRBN -0.62 -9.76 -0.47 6.07e-20 Intelligence (multi-trait analysis); CRC cis rs12130219 0.500 rs4845743 chr1:152184149 A/G cg17718321 chr1:152188247 HRNR -0.35 -7.73 -0.39 1.32e-13 Inflammatory skin disease; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg25062812 chr14:25519484 STXBP6 -0.44 -6.26 -0.33 1.19e-9 Myopia (pathological); CRC cis rs4713118 0.513 rs200971 chr6:27858904 C/T cg02683197 chr6:28174875 NA 0.7 9.6 0.47 2.15e-19 Parkinson's disease; CRC cis rs2979489 0.786 rs2915595 chr8:30402817 A/G cg26383811 chr8:30366931 RBPMS 0.67 10.27 0.49 1.21e-21 Mean corpuscular hemoglobin;Plateletcrit;Neutrophil count;Granulocyte count;Sum basophil neutrophil counts;Mean corpuscular volume;Myeloid white cell count;Sum neutrophil eosinophil counts; CRC cis rs769267 0.930 rs10422819 chr19:19643028 C/A cg01262667 chr19:19385393 TM6SF2 0.36 5.86 0.31 1.1e-8 Tonsillectomy; CRC cis rs875971 0.545 rs7811204 chr7:65852200 G/A cg05627663 chr7:65219948 SNORA22;CCT6P1 0.62 7.92 0.4 3.58e-14 Aortic root size; CRC cis rs11719291 0.651 rs1134043 chr3:49200137 G/T cg00383909 chr3:49044727 WDR6 0.58 6.62 0.34 1.46e-10 Cognitive function; CRC cis rs1005277 0.579 rs1740747 chr10:38520465 G/A cg03665457 chr10:38645376 HSD17B7P2 -0.42 -5.96 -0.31 6.58e-9 Extrinsic epigenetic age acceleration; CRC cis rs62229266 0.773 rs878606 chr21:37406692 G/A cg12218747 chr21:37451666 NA -0.45 -7.72 -0.39 1.41e-13 Mitral valve prolapse; CRC cis rs2760061 0.717 rs708117 chr1:228199902 G/A cg02753203 chr1:228287806 NA 0.68 10.67 0.51 5.19e-23 Diastolic blood pressure; CRC cis rs11190604 1.000 rs11190587 chr10:102266638 C/T cg16342193 chr10:102329863 NA -0.4 -6.42 -0.33 4.83e-10 Palmitoleic acid (16:1n-7) levels; CRC cis rs1799949 0.965 rs9911630 chr17:41188342 A/G cg05368731 chr17:41323189 NBR1 0.63 9.53 0.46 3.73e-19 Menopause (age at onset); CRC cis rs965469 0.947 rs965468 chr20:3381443 C/T cg25506879 chr20:3388711 C20orf194 -0.4 -5.8 -0.3 1.54e-8 IFN-related cytopenia; CRC cis rs7615952 0.512 rs4646765 chr3:125820707 G/A cg02772935 chr3:125709198 NA -0.49 -5.68 -0.3 2.91e-8 Blood pressure (smoking interaction); CRC trans rs6833159 0.527 rs10939231 chr4:28829372 A/T cg09983326 chr2:43451308 ZFP36L2 -0.45 -6.3 -0.33 9.63e-10 Underweight status; CRC cis rs780096 0.526 rs72819536 chr2:27682850 G/T cg12648201 chr2:27665141 KRTCAP3 -0.32 -6.09 -0.32 3.23e-9 Total body bone mineral density; CRC cis rs2455601 1.000 rs7104661 chr11:8902501 C/G cg09997546 chr11:8931473 C11orf17;ST5 -0.51 -6.04 -0.32 4.15e-9 Schizophrenia; CRC cis rs2153535 0.541 rs9328477 chr6:8519109 T/C cg07606381 chr6:8435919 SLC35B3 0.66 10.68 0.51 4.6e-23 Motion sickness; CRC cis rs6502050 0.835 rs28481866 chr17:80105160 G/A cg11859384 chr17:80120422 CCDC57 -0.37 -5.85 -0.31 1.16e-8 Life satisfaction; CRC cis rs6963495 0.818 rs6955796 chr7:105170321 T/G cg02135003 chr7:105160482 PUS7 -0.92 -12.46 -0.57 1.94e-29 Bipolar disorder (body mass index interaction); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg19910922 chr7:139025279 C7orf55 0.37 5.99 0.31 5.58e-9 Liver disease severity in Alagille syndrome; CRC cis rs713477 0.505 rs10131672 chr14:55905091 A/T cg13175173 chr14:55914753 NA -0.42 -6.87 -0.35 3.16e-11 Pediatric bone mineral content (femoral neck); CRC cis rs72781680 1.000 rs74704838 chr2:24158270 C/A cg08917208 chr2:24149416 ATAD2B 0.91 9.3 0.46 2.01e-18 Lymphocyte counts; CRC cis rs7312933 0.558 rs1796388 chr12:42785987 G/C cg19980929 chr12:42632907 YAF2 -0.4 -6.08 -0.32 3.29e-9 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg03700121 chr11:60610004 CCDC86 0.44 6.86 0.35 3.52e-11 Liver disease severity in Alagille syndrome; CRC cis rs4285028 0.699 rs12629742 chr3:121614895 T/C cg20356878 chr3:121714668 ILDR1 -0.48 -6.59 -0.34 1.77e-10 Multiple sclerosis; CRC cis rs2415984 0.600 rs2084823 chr14:46966454 C/G cg14871534 chr14:47121158 RPL10L 0.39 5.93 0.31 7.78e-9 Number of children ever born; CRC cis rs9937943 0.667 rs35253850 chr16:74599103 T/C cg01733217 chr16:74700730 RFWD3 0.72 8.19 0.41 5.71e-15 Neutrophil percentage of white cells; CRC cis rs9807989 0.507 rs2287033 chr2:103011237 C/T cg03938978 chr2:103052716 IL18RAP -0.59 -10.14 -0.49 3.2e-21 Asthma; CRC trans rs6500957 0.920 rs17648524 chr16:7459683 C/G cg15024055 chr5:81267935 ATG10 0.49 7.31 0.37 2.06e-12 Spherical equivalent (joint analysis main effects and education interaction); CRC cis rs11214589 0.620 rs34601878 chr11:113260898 G/A cg14159747 chr11:113255604 NA 0.62 12.68 0.57 2.86e-30 Neuroticism; CRC cis rs4713118 0.513 rs149951 chr6:28033087 T/C cg20615401 chr6:28092323 ZSCAN16 0.47 6.24 0.33 1.34e-9 Parkinson's disease; CRC cis rs6951245 1.000 rs28379681 chr7:1070539 C/T cg26224354 chr7:1096374 C7orf50;GPR146 -0.88 -11.08 -0.52 1.89e-24 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs4665809 1.000 rs7573118 chr2:26308086 A/G cg26119090 chr2:26468346 HADHA;HADHB -0.61 -7.91 -0.4 3.92e-14 Gut microbiome composition (summer); CRC cis rs2652822 0.967 rs1472631 chr15:63423739 A/G cg02713581 chr15:63449717 RPS27L 0.41 6.0 0.31 5.3300000000000004e-09 Metabolic traits; CRC cis rs870825 0.616 rs4616798 chr4:185634144 C/T cg04058563 chr4:185651563 MLF1IP -0.68 -8.43 -0.42 1.1e-15 Blood protein levels; CRC cis rs2836974 0.932 rs6517523 chr21:40557332 T/C cg06238570 chr21:40685208 BRWD1 0.79 10.85 0.51 1.23e-23 Cognitive function; CRC cis rs9903692 0.954 rs2109984 chr17:46171099 G/T cg21215337 chr17:46176117 CBX1 0.42 7.59 0.39 3.24e-13 Pulse pressure; CRC cis rs1008375 1.000 rs17507481 chr4:17620066 A/G cg04450456 chr4:17643702 FAM184B 0.36 5.65 0.3 3.41e-8 Parasitemia in Tripanosoma cruzi seropositivity; CRC trans rs12887734 0.524 rs4900599 chr14:104283444 G/T cg06206626 chr22:26825900 ASPHD2 0.41 6.11 0.32 2.84e-9 Schizophrenia;Autism spectrum disorder or schizophrenia; CRC cis rs11971779 0.680 rs3924445 chr7:139044172 C/A cg07862535 chr7:139043722 LUC7L2 0.57 7.35 0.38 1.61e-12 Diisocyanate-induced asthma; CRC cis rs10540 1.000 rs61876333 chr11:487136 G/A cg03934478 chr11:495069 RNH1 0.67 6.83 0.35 4.21e-11 Body mass index; CRC cis rs9486719 1.000 rs9486719 chr6:97060124 G/A cg06623918 chr6:96969491 KIAA0776 -0.81 -10.77 -0.51 2.24e-23 Migraine;Coronary artery disease; CRC cis rs9914988 0.943 rs11658884 chr17:27132742 A/G cg12682573 chr17:27188876 MIR451;MIR144 -0.57 -7.9 -0.4 4.32e-14 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg02010868 chr19:4067159 ZBTB7A 0.42 6.3 0.33 9.43e-10 Intelligence (multi-trait analysis); CRC cis rs995000 0.931 rs1168021 chr1:63009900 A/G cg19896129 chr1:63156450 NA -0.44 -6.78 -0.35 5.74e-11 Triglyceride levels; CRC cis rs758324 0.898 rs11958749 chr5:131166014 T/C cg25547332 chr5:131281432 NA 0.38 5.79 0.3 1.64e-8 Alzheimer's disease in APOE e4- carriers; CRC cis rs7727544 0.654 rs4705849 chr5:131559199 T/A cg12564285 chr5:131593104 PDLIM4 0.39 7.34 0.38 1.63e-12 Blood metabolite levels; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg00243897 chr12:122326549 PSMD9 0.39 6.28 0.33 1.06e-9 Liver disease severity in Alagille syndrome; CRC cis rs7113874 0.610 rs1446462 chr11:8566343 C/T cg02811074 chr11:8615871 STK33 -0.36 -6.14 -0.32 2.44e-9 Body mass index in physically active individuals;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs736408 0.527 rs2336147 chr3:52626443 T/C cg15147215 chr3:52552868 STAB1 -0.69 -12.91 -0.58 3.86e-31 Bipolar disorder; CRC cis rs35740288 0.539 rs34362339 chr15:86337628 C/T cg20737812 chr15:86336631 KLHL25 -0.44 -7.08 -0.36 8.51e-12 Eosinophil percentage of white cells;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes; CRC cis rs597539 0.652 rs488363 chr11:68658298 C/G cg06028808 chr11:68637592 NA 0.4 6.34 0.33 7.42e-10 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs4285028 0.796 rs12638492 chr3:121711763 G/A cg20356878 chr3:121714668 ILDR1 -0.51 -7.11 -0.36 7.34e-12 Multiple sclerosis; CRC cis rs2243480 1.000 rs34560516 chr7:65404092 A/T cg25985355 chr7:65971099 NA -0.48 -5.65 -0.3 3.53e-8 Diabetic kidney disease; CRC cis rs1799949 1.000 rs36036395 chr17:41181297 T/C cg25072359 chr17:41440525 NA 0.47 6.91 0.36 2.53e-11 Menopause (age at onset); CRC cis rs9894429 1.000 rs4074916 chr17:79579248 G/A cg18240062 chr17:79603768 NPLOC4 -0.56 -9.38 -0.46 1.11e-18 Eye color traits; CRC trans rs2948294 0.566 rs13261997 chr8:8112295 C/T cg16141378 chr3:129829833 LOC729375 -0.47 -6.14 -0.32 2.33e-9 Red cell distribution width; CRC cis rs6952808 1.000 rs6977733 chr7:1886725 A/T cg00106254 chr7:1943704 MAD1L1 0.43 6.12 0.32 2.59e-9 Bipolar disorder and schizophrenia; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg16616022 chr6:57086293 RAB23 0.44 6.4 0.33 5.27e-10 Response to antipsychotic treatment; CRC cis rs2456568 0.900 rs2511373 chr11:93671414 T/C cg26875233 chr11:93583750 C11orf90 -0.34 -6.59 -0.34 1.7e-10 Response to serotonin reuptake inhibitors in major depressive disorder; CRC cis rs7811142 1.000 rs11766752 chr7:100073292 A/G cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.16 17.21 0.69 8.33e-48 Platelet count; CRC cis rs1129187 0.902 rs6907751 chr6:42944850 C/T cg09436375 chr6:42928200 GNMT -0.31 -5.77 -0.3 1.82e-8 Alzheimer's disease in APOE e4+ carriers; CRC cis rs13191362 1.000 rs35017019 chr6:162982581 A/G cg23758597 chr6:163146217 PARK2 -0.56 -6.18 -0.32 1.93e-9 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs9837602 0.938 rs1021341 chr3:99786289 A/G cg07805332 chr3:99536008 MIR548G;C3orf26 -0.5 -6.58 -0.34 1.85e-10 Breast cancer; CRC cis rs6582630 0.555 rs11182422 chr12:38522833 A/G cg13010199 chr12:38710504 ALG10B 0.47 6.43 0.33 4.59e-10 Drug-induced liver injury (flucloxacillin); CRC cis rs6460942 1.000 rs62448566 chr7:12403662 G/A cg06484146 chr7:12443880 VWDE -0.77 -7.65 -0.39 2.2e-13 Coronary artery disease; CRC cis rs231513 0.954 rs231506 chr17:41970191 A/G cg26893861 chr17:41843967 DUSP3 -0.63 -6.32 -0.33 8.53e-10 Cognitive function; CRC cis rs2274273 0.840 rs10136596 chr14:55836773 A/G cg23234261 chr14:55582407 NA -0.28 -5.61 -0.3 4.38e-8 Protein biomarker; CRC cis rs17376456 0.825 rs66564678 chr5:93165894 C/T cg09848695 chr5:92956644 FAM172A;MIR2277 0.69 6.31 0.33 9.01e-10 Diabetic retinopathy; CRC cis rs10479542 0.784 rs6896940 chr5:178985994 G/C cg05457628 chr5:178986728 RUFY1 0.43 7.36 0.38 1.5e-12 Lung cancer; CRC cis rs9372498 0.505 rs72956993 chr6:118949708 A/T cg07617317 chr6:118971624 C6orf204 0.47 5.68 0.3 2.91e-8 Diastolic blood pressure; CRC cis rs9911578 0.805 rs12601867 chr17:56455260 C/G cg05425664 chr17:57184151 TRIM37 0.43 6.82 0.35 4.26e-11 Intelligence (multi-trait analysis); CRC cis rs35264875 0.846 rs72930625 chr11:68867120 T/A cg03469862 chr11:68924853 NA 0.45 5.74 0.3 2.17e-8 Blond vs. brown hair color; CRC cis rs4862750 0.872 rs9998173 chr4:187898778 T/A cg11301795 chr4:187892539 NA -0.87 -19.96 -0.74 1.28e-58 Lobe attachment (rater-scored or self-reported); CRC cis rs6496044 0.547 rs1564719 chr15:86054266 C/T cg17133734 chr15:86042851 AKAP13 0.43 7.07 0.36 9.28e-12 Interstitial lung disease; CRC cis rs763121 0.744 rs5757140 chr22:38957013 T/C cg06022373 chr22:39101656 GTPBP1 0.7 10.29 0.49 1.01e-21 Menopause (age at onset); CRC cis rs2153535 0.505 rs9405395 chr6:8468622 T/A cg07606381 chr6:8435919 SLC35B3 0.68 10.93 0.52 6.5e-24 Motion sickness; CRC cis rs8038465 0.638 rs8036954 chr15:73974282 T/C cg15420318 chr15:73925796 NPTN 0.42 6.34 0.33 7.64e-10 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs13256369 1.000 rs13266699 chr8:8570313 A/T cg18904891 chr8:8559673 CLDN23 -0.49 -6.62 -0.34 1.42e-10 Obesity-related traits; CRC cis rs514406 0.861 rs4926576 chr1:53226775 C/T cg27535305 chr1:53392650 SCP2 0.38 6.97 0.36 1.77e-11 Monocyte count; CRC cis rs853679 0.517 rs9366715 chr6:28064633 A/G cg02683197 chr6:28174875 NA 0.82 10.05 0.48 6.9e-21 Depression; CRC cis rs7945718 0.839 rs11022511 chr11:12834638 A/T cg25843174 chr11:12811716 TEAD1 0.5 9.42 0.46 8.39e-19 Educational attainment (years of education); CRC cis rs9435341 0.965 rs9435441 chr1:107603330 C/G cg14671364 chr1:107599128 PRMT6 -0.53 -7.57 -0.39 3.7e-13 Facial morphology (factor 21, depth of nasal alae); CRC cis rs6500602 0.592 rs4785966 chr16:4518754 C/T cg06139259 chr16:4526053 HMOX2;NMRAL1 -0.42 -5.64 -0.3 3.71e-8 Schizophrenia; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg10444037 chr6:42531637 UBR2 0.48 6.12 0.32 2.67e-9 Thyroid stimulating hormone; CRC cis rs6725517 0.737 rs7576788 chr2:25083310 A/G cg22495460 chr2:25135724 ADCY3 -0.8 -14.5 -0.62 3.65e-37 Breast cancer; CRC cis rs9902453 0.765 rs2874505 chr17:28037923 A/G cg26525008 chr17:28256777 EFCAB5;SSH2 0.7 11.71 0.54 1.03e-26 Coffee consumption (cups per day); CRC cis rs9303401 0.703 rs9909925 chr17:57210069 C/T cg10487724 chr17:56770010 TEX14;RAD51C -0.48 -7.31 -0.37 2.06e-12 Cognitive test performance; CRC cis rs9467711 0.591 rs17586553 chr6:25928775 C/T cg16898833 chr6:26189333 HIST1H4D 0.73 6.4 0.33 5.36e-10 Autism spectrum disorder or schizophrenia; CRC cis rs9649213 0.593 rs6465664 chr7:97921834 A/G cg24562669 chr7:97807699 LMTK2 0.45 7.54 0.38 4.56e-13 Prostate cancer (SNP x SNP interaction); CRC cis rs77106637 1.000 rs11600585 chr11:72727840 A/G cg03713592 chr11:72463424 ARAP1 0.79 7.67 0.39 2.01e-13 Type 2 diabetes; CRC cis rs10504229 0.683 rs7827881 chr8:58132137 C/T cg02725872 chr8:58115012 NA -0.64 -11.45 -0.53 8.92e-26 Developmental language disorder (linguistic errors); CRC cis rs6585424 1.000 rs56190825 chr10:81934736 C/T cg11900509 chr10:81946545 ANXA11 -0.72 -8.83 -0.44 6.14e-17 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs912330 0.825 rs7317938 chr13:99234361 C/T cg20487152 chr13:99095054 FARP1 -0.39 -6.03 -0.32 4.32e-9 Alzheimer's disease; CRC cis rs7394190 1.000 rs7394190 chr10:75421648 G/A cg26549892 chr10:75416844 SYNPO2L -0.48 -6.06 -0.32 3.74e-9 Incident atrial fibrillation; CRC cis rs9487051 0.676 rs6568567 chr6:109596993 A/G cg12927641 chr6:109611667 NA -0.36 -6.44 -0.33 4.15e-10 Reticulocyte fraction of red cells; CRC trans rs916888 0.531 rs183211 chr17:44788310 G/A cg22433210 chr17:43662623 NA 0.64 7.7 0.39 1.66e-13 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs477895 0.838 rs11607007 chr11:64007976 C/T cg04317338 chr11:64019027 PLCB3 0.72 8.71 0.43 1.51e-16 Mean platelet volume; CRC cis rs11676348 0.967 rs4674258 chr2:218990586 C/T cg00012203 chr2:219082015 ARPC2 -0.38 -5.73 -0.3 2.24e-8 Ulcerative colitis; CRC cis rs6598955 0.670 rs3795688 chr1:26560481 C/A cg04990556 chr1:26633338 UBXN11 -0.79 -13.15 -0.59 4.94e-32 Obesity-related traits; CRC cis rs7811142 1.000 rs67163493 chr7:100023838 C/T cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.19 17.8 0.7 4.05e-50 Platelet count; CRC trans rs2303319 0.504 rs62189048 chr2:162613494 G/C cg20024234 chr21:43431083 ZNF295 -0.66 -5.99 -0.31 5.57e-9 Cognitive function; CRC cis rs2836974 0.799 rs13047550 chr21:40515495 T/C cg11890956 chr21:40555474 PSMG1 1.0 15.6 0.65 1.81e-41 Cognitive function; CRC cis rs4713118 0.591 rs2056924 chr6:27690174 G/A cg02683197 chr6:28174875 NA 0.63 8.92 0.44 3.22e-17 Parkinson's disease; CRC cis rs1129187 0.967 rs3805952 chr6:42937126 C/T cg09436375 chr6:42928200 GNMT -0.32 -5.77 -0.3 1.86e-8 Alzheimer's disease in APOE e4+ carriers; CRC cis rs6570726 0.818 rs952405 chr6:145925952 T/C cg05347473 chr6:146136440 FBXO30 0.37 5.63 0.3 3.79e-8 Lobe attachment (rater-scored or self-reported); CRC cis rs9488822 0.676 rs4354188 chr6:116327936 T/C cg26893134 chr6:116381904 FRK 0.26 7.61 0.39 2.98e-13 Cholesterol, total;LDL cholesterol; CRC cis rs290268 0.838 rs1319677 chr9:93565999 A/G cg02608019 chr9:93564028 SYK 0.44 6.91 0.36 2.46e-11 Platelet count; CRC cis rs8180040 0.739 rs12488225 chr3:47235107 G/A cg02527881 chr3:46936655 PTH1R -0.38 -7.07 -0.36 9.12e-12 Colorectal cancer; CRC cis rs12476592 0.602 rs10176522 chr2:63722433 T/C cg10828910 chr2:63850056 LOC388955 0.48 5.8 0.3 1.54e-8 Childhood ear infection; CRC trans rs783540 1.000 rs11631963 chr15:83318202 T/C cg18393722 chr15:85113863 UBE2QP1 0.37 6.08 0.32 3.32e-9 Schizophrenia; CRC trans rs596169 0.655 rs12087006 chr1:219203397 T/C cg00778190 chr1:95068029 NA 0.76 6.6 0.34 1.67e-10 Intraocular pressure; CRC cis rs2019137 0.936 rs4849169 chr2:113953657 A/C cg21482265 chr2:113992762 PAX8;LOC440839;LOC654433 -0.48 -6.77 -0.35 5.81e-11 Lymphocyte counts; CRC cis rs2730260 0.611 rs73169221 chr7:158846316 T/A cg02254261 chr7:158964346 NA -0.56 -6.2 -0.32 1.68e-9 Myopia (pathological); CRC cis rs72945132 0.882 rs6592522 chr11:70128271 G/A cg14191688 chr11:70257035 CTTN 0.47 6.24 0.33 1.33e-9 Coronary artery disease; CRC cis rs4676482 0.841 rs34810344 chr3:39226114 G/A cg02254461 chr3:39195904 CSRNP1 0.51 6.24 0.33 1.36e-9 Colonoscopy-negative controls vs population controls; CRC cis rs315934 0.664 rs10199363 chr2:113840791 A/G cg24553058 chr2:113831203 IL1F10 -0.49 -5.62 -0.3 4.16e-8 Dysmenorrheic pain; CRC cis rs896854 0.654 rs13248607 chr8:95986637 T/G cg13393036 chr8:95962371 TP53INP1 -0.52 -8.78 -0.44 9.2e-17 Type 2 diabetes; CRC trans rs6780569 0.655 rs17012829 chr3:23261334 C/T cg12985929 chr17:75370611 SEPT9 -0.52 -6.1 -0.32 2.96e-9 Type 2 diabetes; CRC cis rs4555082 0.834 rs1473672 chr14:105721981 G/T cg06808227 chr14:105710500 BRF1 -0.62 -8.83 -0.44 6.23e-17 Mean platelet volume;Platelet distribution width; CRC cis rs4319547 0.695 rs11058034 chr12:122894936 G/T cg23029597 chr12:123009494 RSRC2 0.58 6.55 0.34 2.22e-10 Body mass index; CRC cis rs11212617 0.934 rs694376 chr11:108119048 C/A cg12106634 chr11:108092400 ATM;NPAT 0.39 5.72 0.3 2.35e-8 Response to metformin in type 2 diabetes (glycemic); CRC cis rs3733585 0.673 rs6449156 chr4:9956712 G/C cg11266682 chr4:10021025 SLC2A9 -0.47 -9.66 -0.47 1.31e-19 Cleft plate (environmental tobacco smoke interaction); CRC cis rs10504073 0.669 rs341802 chr8:50039313 C/T cg00325661 chr8:49890786 NA 0.45 8.03 0.4 1.78e-14 Blood metabolite ratios; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg13056269 chr2:136633607 MCM6 0.44 6.28 0.33 1.06e-9 Response to antipsychotic treatment; CRC cis rs11785400 0.793 rs4581034 chr8:143736968 G/A cg24634471 chr8:143751801 JRK 0.47 6.4 0.33 5.25e-10 Schizophrenia; CRC cis rs9469578 0.710 rs73743330 chr6:33713971 G/A cg18708504 chr6:33715942 IP6K3 0.66 7.56 0.38 4e-13 Phosphorus levels; CRC cis rs875971 0.660 rs7807944 chr7:66087195 C/G cg11764359 chr7:65958608 NA -0.54 -8.39 -0.42 1.47e-15 Aortic root size; CRC trans rs2228479 0.867 rs62052187 chr16:89973071 G/A cg24644049 chr4:85504048 CDS1 0.77 7.55 0.38 4.3e-13 Skin colour saturation; CRC cis rs7412746 0.611 rs11204748 chr1:150927369 G/T cg10589385 chr1:150898437 SETDB1 0.27 5.92 0.31 7.89e-9 Melanoma; CRC cis rs7772486 0.597 rs2246132 chr6:146182515 C/G cg05347473 chr6:146136440 FBXO30 0.5 7.12 0.37 7e-12 Lobe attachment (rater-scored or self-reported); CRC cis rs6429082 0.764 rs291369 chr1:235691913 T/C cg26050004 chr1:235667680 B3GALNT2 0.57 7.54 0.38 4.64e-13 Adiposity; CRC cis rs2976388 0.566 rs4736373 chr8:143792357 G/C cg24046110 chr8:143859143 LYNX1 -0.47 -7.47 -0.38 7.4e-13 Urinary tract infection frequency; CRC cis rs7713065 0.531 rs2522051 chr5:131797578 C/T cg04518342 chr5:131593106 PDLIM4 0.33 5.88 0.31 1.03e-8 Lung function (FEV1/FVC); CRC cis rs9322193 0.923 rs9766037 chr6:149938057 A/C cg07701084 chr6:150067640 NUP43 0.52 7.63 0.39 2.54e-13 Lung cancer; CRC cis rs2204008 0.571 rs8175738 chr12:38311234 C/T cg26384229 chr12:38710491 ALG10B -0.52 -7.57 -0.39 3.68e-13 Bladder cancer; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg04569364 chr19:57922590 ZNF17 0.48 6.71 0.35 8.55e-11 Response to antipsychotic treatment; CRC cis rs735396 0.770 rs2464196 chr12:121435427 G/A cg02403541 chr12:121454288 C12orf43 0.49 7.23 0.37 3.36e-12 N-glycan levels; CRC cis rs10045504 0.502 rs57589709 chr5:38733853 C/T cg15396434 chr5:38725168 NA -0.57 -5.67 -0.3 3.17e-8 Night sleep phenotypes; CRC trans rs7618501 0.602 rs34831713 chr3:50118748 T/C cg21665057 chr3:196295764 WDR53;FBXO45 -0.57 -9.14 -0.45 6.39e-18 Intelligence (multi-trait analysis); CRC trans rs6819266 0.636 rs13148734 chr4:63330858 A/G cg09192942 chr16:75682004 KARS;TERF2IP 0.38 6.01 0.31 4.98e-9 Age-related macular degeneration; CRC cis rs7020830 0.516 rs36047049 chr9:37375472 G/T cg14294708 chr9:37120828 ZCCHC7 0.85 10.97 0.52 4.7e-24 Schizophrenia; CRC cis rs13256369 0.802 rs12681326 chr8:8566389 G/A cg17143192 chr8:8559678 CLDN23 0.49 6.29 0.33 1.02e-9 Obesity-related traits; CRC cis rs72945132 0.522 rs4367974 chr11:70248900 C/T cg14191688 chr11:70257035 CTTN 0.44 6.76 0.35 6.42e-11 Coronary artery disease; CRC trans rs559356 0.561 rs44338 chr3:34834586 G/A cg19071035 chr6:20404090 E2F3 0.46 6.2 0.32 1.67e-9 Cognitive function; CRC cis rs1799949 1.000 rs16942 chr17:41244000 T/C cg23758822 chr17:41437982 NA 0.8 13.49 0.6 2.61e-33 Menopause (age at onset); CRC cis rs12497850 0.931 rs9755490 chr3:48871664 A/C cg20833759 chr3:49053208 WDR6;DALRD3 0.53 9.14 0.45 6.55e-18 Parkinson's disease; CRC cis rs7258465 1.000 rs34171762 chr19:18559410 G/A cg01065977 chr19:18549689 ISYNA1 -0.41 -6.43 -0.33 4.47e-10 Breast cancer; CRC cis rs7493 1.000 rs2299264 chr7:95046708 C/T cg19678392 chr7:94953810 PON1 -0.57 -7.35 -0.38 1.56e-12 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs9372253 0.678 rs9372251 chr6:110700656 A/G cg01119278 chr6:110721349 DDO -0.36 -5.67 -0.3 3.11e-8 Platelet distribution width; CRC cis rs4423214 0.802 rs4616066 chr11:71183846 G/A cg13043300 chr11:71146211 DHCR7 -0.44 -5.98 -0.31 5.98e-9 Vitamin D levels; CRC cis rs10946940 0.965 rs4713112 chr6:27516833 G/T cg25164649 chr6:28176230 NA -0.41 -5.62 -0.3 4.07e-8 Systemic lupus erythematosus; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg19891435 chr13:114145178 DCUN1D2;TMCO3 0.39 6.15 0.32 2.21e-9 Intelligence (multi-trait analysis); CRC cis rs9303280 0.806 rs2305480 chr17:38062196 G/A cg17344932 chr17:38183730 MED24;SNORD124 0.39 6.22 0.32 1.48e-9 Self-reported allergy; CRC trans rs2243480 1.000 rs160633 chr7:65528228 T/C cg10756647 chr7:56101905 PSPH 0.66 6.96 0.36 1.9e-11 Diabetic kidney disease; CRC cis rs9463078 0.801 rs9395079 chr6:45154433 C/T cg25276700 chr6:44698697 NA -0.29 -6.88 -0.35 3.1e-11 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; CRC cis rs3996993 0.809 rs58912740 chr6:52669759 G/C cg20803780 chr6:52668592 GSTA1 0.35 6.28 0.33 1.08e-9 Hemoglobin concentration; CRC cis rs6761276 0.649 rs3811057 chr2:113831188 C/A cg09040174 chr2:113837401 NA 0.43 5.79 0.3 1.64e-8 Protein quantitative trait loci; CRC cis rs9487051 0.714 rs7744284 chr6:109616218 C/T cg21918786 chr6:109611834 NA -0.42 -7.43 -0.38 9.24e-13 Reticulocyte fraction of red cells; CRC cis rs10504229 0.683 rs58438731 chr8:58134790 C/T cg02725872 chr8:58115012 NA -0.64 -11.55 -0.54 3.85e-26 Developmental language disorder (linguistic errors); CRC cis rs13315871 1.000 rs11706420 chr3:58392411 C/T cg20936604 chr3:58311152 NA 0.68 6.74 0.35 7.11e-11 Cholesterol, total; CRC cis rs2354432 1.000 rs10900325 chr1:146692174 C/T cg25205988 chr1:146714368 CHD1L -1.08 -12.52 -0.57 1.15e-29 Mitochondrial DNA levels; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg16641818 chr10:45869619 ALOX5 0.38 6.37 0.33 6.5e-10 Liver disease severity in Alagille syndrome; CRC cis rs35110281 0.782 rs2838329 chr21:45023329 T/C cg01579765 chr21:45077557 HSF2BP -0.38 -7.29 -0.37 2.39e-12 Mean corpuscular volume; CRC cis rs344364 0.511 rs12596510 chr16:1949480 G/A cg14074117 chr16:1909714 C16orf73 0.41 5.66 0.3 3.28e-8 Glomerular filtration rate in chronic kidney disease; CRC cis rs3096299 0.781 rs2965819 chr16:89501030 G/T cg01788221 chr16:89496183 ANKRD11 0.4 5.88 0.31 1.01e-8 Multiple myeloma (IgH translocation); CRC cis rs801193 0.569 rs2659908 chr7:66160822 G/A cg18876405 chr7:65276391 NA 0.51 8.18 0.41 6.31e-15 Aortic root size; CRC cis rs17711722 0.565 rs4717276 chr7:65294741 G/T cg02869306 chr7:64672164 INTS4L1 -0.46 -7.96 -0.4 2.83e-14 Calcium levels; CRC cis rs7312933 0.670 rs2406568 chr12:42552297 G/C cg19980929 chr12:42632907 YAF2 0.44 6.55 0.34 2.22e-10 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CRC cis rs9584850 0.520 rs10508036 chr13:99157398 C/G cg20487152 chr13:99095054 FARP1 -0.44 -5.7 -0.3 2.64e-8 Neuroticism; CRC cis rs7618915 0.524 rs35249778 chr3:52661640 G/C cg15147215 chr3:52552868 STAB1 -0.61 -10.21 -0.49 1.97e-21 Bipolar disorder; CRC cis rs1348850 0.874 rs952746 chr2:178306584 A/G cg22681709 chr2:178499509 PDE11A -0.36 -6.65 -0.34 1.22e-10 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs642803 1.000 rs557675 chr11:65566719 G/T cg27068330 chr11:65405492 SIPA1 -0.45 -6.65 -0.34 1.2e-10 Urate levels; CRC cis rs8060686 0.920 rs58588228 chr16:67802010 C/T cg04539111 chr16:67997858 SLC12A4 -0.51 -5.91 -0.31 8.72e-9 HDL cholesterol;Metabolic syndrome; CRC cis rs4664293 0.647 rs2042775 chr2:160510092 T/G cg08347373 chr2:160653686 CD302 0.39 6.68 0.35 1.03e-10 Monocyte percentage of white cells; CRC cis rs10504229 0.610 rs6987118 chr8:58147851 G/T cg24829409 chr8:58192753 C8orf71 -0.53 -8.3 -0.42 2.75e-15 Developmental language disorder (linguistic errors); CRC cis rs919433 0.713 rs13411968 chr2:198467141 C/T cg10820045 chr2:198174542 NA 0.42 7.16 0.37 5.45e-12 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC trans rs875971 0.660 rs2191268 chr7:66110224 C/T cg17675882 chr20:35374068 NDRG3 -0.4 -6.19 -0.32 1.75e-9 Aortic root size; CRC cis rs2976388 0.609 rs2717601 chr8:143807924 T/C cg24046110 chr8:143859143 LYNX1 0.49 8.49 0.42 7.22e-16 Urinary tract infection frequency; CRC cis rs736408 0.521 rs13074853 chr3:52779801 T/C cg18404041 chr3:52824283 ITIH1 -0.41 -8.4 -0.42 1.36e-15 Bipolar disorder; CRC cis rs9393692 0.967 rs6456712 chr6:26302573 A/C cg13736514 chr6:26305472 NA -0.65 -11.75 -0.54 7.23e-27 Educational attainment; CRC cis rs243505 0.660 rs7785022 chr7:148533384 C/T cg09806900 chr7:148480153 CUL1 0.52 6.77 0.35 5.78e-11 Inflammatory bowel disease;Crohn's disease; CRC trans rs1814175 0.817 rs4881645 chr11:49791168 G/A cg21153622 chr11:89784906 NA -0.37 -6.0 -0.31 5.16e-9 Height; CRC cis rs2274273 0.662 rs67092614 chr14:55672055 G/A cg10130446 chr14:55658398 DLGAP5 -0.43 -5.81 -0.31 1.46e-8 Protein biomarker; CRC cis rs7072216 0.727 rs6584199 chr10:100169983 A/G cg26618903 chr10:100175079 PYROXD2 -0.55 -9.16 -0.45 5.81e-18 Metabolite levels; CRC cis rs4727963 0.792 rs12665913 chr7:122741302 T/C cg03640110 chr7:122635026 TAS2R16 0.35 6.33 0.33 8.25e-10 Adverse response to chemotherapy (neutropenia/leucopenia) (docetaxel); CRC cis rs9747201 0.926 rs35131420 chr17:80103631 T/C cg14673194 chr17:80132900 CCDC57 0.49 6.35 0.33 7.03e-10 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs6951245 1.000 rs78185801 chr7:1096367 G/A cg04025307 chr7:1156635 C7orf50 0.63 6.74 0.35 7.02e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs6502050 0.835 rs28640920 chr17:80105151 A/T cg09264619 chr17:80180166 NA -0.34 -5.81 -0.3 1.5e-8 Life satisfaction; CRC cis rs2797160 0.651 rs1268092 chr6:126029043 A/G cg05901451 chr6:126070800 HEY2 -0.53 -8.6 -0.43 3.31e-16 Endometrial cancer; CRC cis rs67478160 0.643 rs11160762 chr14:104255083 A/G cg01849466 chr14:104193079 ZFYVE21 0.46 8.23 0.41 4.49e-15 Schizophrenia; CRC cis rs7312933 0.531 rs2708059 chr12:42851008 C/T cg11827402 chr12:42719852 PPHLN1;ZCRB1 -0.64 -9.04 -0.45 1.36e-17 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CRC cis rs1387259 0.931 rs1107654 chr12:48681097 T/G cg21466736 chr12:48725269 NA -0.55 -8.18 -0.41 6.36e-15 Obstructive sleep apnea trait (apnea hypopnea index); CRC cis rs826838 0.967 rs11183514 chr12:38760744 A/T cg13010199 chr12:38710504 ALG10B 0.46 6.02 0.32 4.65e-9 Heart rate; CRC cis rs79387448 0.810 rs76229479 chr2:103123912 A/C cg00507830 chr2:103233733 NA 0.62 6.53 0.34 2.46e-10 Gut microbiota (bacterial taxa); CRC cis rs10504229 0.728 rs17215851 chr8:58154160 A/C cg24829409 chr8:58192753 C8orf71 -0.58 -7.96 -0.4 2.86e-14 Developmental language disorder (linguistic errors); CRC cis rs7249142 0.562 rs2239370 chr19:19292674 T/C cg08207377 chr19:19281140 LOC729991-MEF2B;MEF2B -0.35 -5.72 -0.3 2.39e-8 IgG glycosylation; CRC cis rs1799949 0.930 rs2298861 chr17:41176831 G/A cg25072359 chr17:41440525 NA 0.47 6.91 0.36 2.53e-11 Menopause (age at onset); CRC cis rs7107174 0.901 rs2912 chr11:77926292 G/A cg02023728 chr11:77925099 USP35 0.52 7.35 0.38 1.62e-12 Testicular germ cell tumor; CRC trans rs1656966 1.000 rs1656966 chr3:186466252 C/T cg05002732 chr11:19262474 E2F8 0.41 5.98 0.31 5.9e-9 Myopia (pathological); CRC trans rs66887589 0.807 rs13134517 chr4:120405262 G/A cg25214090 chr10:38739885 LOC399744 0.41 6.44 0.33 4.19e-10 Diastolic blood pressure; CRC cis rs873946 0.564 rs35831787 chr10:134546346 T/C cg26818010 chr10:134567672 INPP5A -0.57 -7.83 -0.4 6.63e-14 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg14503987 chr14:102786530 ZNF839 0.39 6.03 0.32 4.31e-9 Liver disease severity in Alagille syndrome; CRC cis rs7481584 0.581 rs515481 chr11:3047184 A/G cg25174290 chr11:3078921 CARS -0.4 -5.65 -0.3 3.5e-8 Calcium levels; CRC cis rs728616 0.867 rs55666905 chr10:81953639 C/T cg05935833 chr10:81318306 SFTPA2 -0.72 -7.38 -0.38 1.27e-12 Chronic obstructive pulmonary disease-related biomarkers; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg08767708 chr16:73082503 ZFHX3 0.41 6.66 0.34 1.15e-10 Liver disease severity in Alagille syndrome; CRC cis rs12477438 0.765 rs7571390 chr2:99626593 C/T cg26064155 chr2:99771622 LIPT1;TSGA10 -0.62 -8.56 -0.43 4.28e-16 Chronic sinus infection; CRC trans rs12310956 0.532 rs1525903 chr12:33964163 T/C cg26384229 chr12:38710491 ALG10B 0.47 6.4 0.33 5.2e-10 Morning vs. evening chronotype; CRC cis rs7224685 0.501 rs8066272 chr17:3900528 C/T cg11204139 chr17:3907470 NA 0.82 16.33 0.67 2.53e-44 Type 2 diabetes; CRC cis rs9896933 0.732 rs590886 chr17:80767350 A/G cg02398342 chr17:80708632 TBCD;FN3K -0.5 -6.31 -0.33 9.15e-10 Bone mineral accretion in asthma (oral corticosteroid dose interaction); CRC cis rs6879260 1.000 rs7725605 chr5:179732678 T/G cg23248424 chr5:179741104 GFPT2 -0.65 -10.13 -0.49 3.72e-21 Height; CRC cis rs2425143 1.000 rs4504072 chr20:34448773 G/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.5 -5.63 -0.3 3.77e-8 Blood protein levels; CRC trans rs2014572 0.967 rs8112572 chr19:57759612 T/C cg02674126 chr19:40336878 FBL 0.42 6.69 0.35 9.76e-11 Hyperactive-impulsive symptoms; CRC trans rs11039798 0.844 rs6485820 chr11:48264711 A/G cg27395922 chr11:50257633 LOC441601 0.48 6.05 0.32 3.87e-9 Axial length; CRC cis rs9393777 0.528 rs34843552 chr6:27241915 A/G cg12292205 chr6:26970375 C6orf41 -0.71 -9.09 -0.45 9.43e-18 Intelligence (multi-trait analysis); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg01951308 chr20:30865502 KIF3B 0.41 6.25 0.33 1.25e-9 Intelligence (multi-trait analysis); CRC cis rs6964587 0.869 rs7778667 chr7:91520816 C/G cg17063962 chr7:91808500 NA -0.73 -12.1 -0.55 4.12e-28 Breast cancer; CRC cis rs2276314 0.793 rs77590522 chr18:33629410 C/G cg19628046 chr18:33552617 C18orf21 0.56 7.2 0.37 4.24e-12 Endometriosis;Drug-induced torsades de pointes; CRC cis rs9926296 0.605 rs886951 chr16:89836865 A/G cg03388025 chr16:89894329 SPIRE2 0.44 8.74 0.43 1.17e-16 Vitiligo; CRC cis rs2077654 0.822 rs7939973 chr11:17433291 G/T cg25308976 chr11:17434268 ABCC8 0.81 8.39 0.42 1.48e-15 Gout; CRC trans rs12660387 1.000 rs12664313 chr6:65271611 A/G cg13393512 chr9:135749454 C9orf98 0.51 5.98 0.31 5.97e-9 Schizophrenia; CRC cis rs9733 0.544 rs72700902 chr1:150633347 C/T cg17724175 chr1:150552817 MCL1 0.59 9.61 0.47 2.03e-19 Tonsillectomy; CRC cis rs5753618 0.583 rs2273249 chr22:31836486 T/C cg22777020 chr22:31556080 RNF185 0.47 5.72 0.3 2.4e-8 Colorectal cancer; CRC cis rs3026445 0.925 rs3759384 chr12:110888857 C/T cg12870014 chr12:110450643 ANKRD13A 0.38 5.94 0.31 7.23e-9 QT interval; CRC cis rs1552244 0.882 rs13077641 chr3:10022935 G/A cg08888203 chr3:10149979 C3orf24 0.62 8.23 0.41 4.29e-15 Alzheimer's disease; CRC cis rs9443189 0.615 rs602873 chr6:76323818 T/A cg01950844 chr6:76311363 SENP6 0.75 10.02 0.48 8.78e-21 Prostate cancer; CRC cis rs6540559 1.000 rs12070337 chr1:209992127 G/A cg23283495 chr1:209979779 IRF6 0.44 6.65 0.34 1.19e-10 Cleft lip with or without cleft palate; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg06476344 chr2:26396290 FAM59B 0.4 6.24 0.33 1.38e-9 Liver disease severity in Alagille syndrome; CRC trans rs9467711 0.559 rs13208916 chr6:26601940 G/A cg06606381 chr12:133084897 FBRSL1 -0.8 -6.21 -0.32 1.56e-9 Autism spectrum disorder or schizophrenia; CRC cis rs4631830 0.720 rs2125770 chr10:51514824 T/C cg20129853 chr10:51489980 NA -0.36 -5.85 -0.31 1.16e-8 Prostate-specific antigen levels; CRC cis rs514406 0.505 rs374849 chr1:53185631 G/A cg27535305 chr1:53392650 SCP2 -0.34 -6.08 -0.32 3.26e-9 Monocyte count; CRC cis rs9409565 0.787 rs11789704 chr9:97233408 C/T cg04523069 chr9:97136363 HIATL1 0.4 6.12 0.32 2.68e-9 Colorectal cancer (alcohol consumption interaction); CRC cis rs6545883 0.507 rs62149712 chr2:61601272 T/C cg10580144 chr2:61372316 C2orf74 -0.37 -8.37 -0.42 1.64e-15 Tuberculosis; CRC cis rs9322193 0.884 rs7744105 chr6:150170444 A/G cg13206674 chr6:150067644 NUP43 0.57 8.01 0.4 1.94e-14 Lung cancer; CRC cis rs748404 0.660 rs493377 chr15:43773467 C/T cg02155558 chr15:43621948 ADAL;LCMT2 0.51 7.31 0.37 2.04e-12 Lung cancer; CRC cis rs7605378 0.528 rs7592587 chr2:200786516 C/G cg23649088 chr2:200775458 C2orf69 0.7 11.38 0.53 1.63e-25 Osteoporosis; CRC cis rs3540 0.960 rs2238329 chr15:91028401 G/A cg22089800 chr15:90895588 ZNF774 0.48 7.69 0.39 1.73e-13 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; CRC cis rs540254 0.578 rs3817407 chr1:160788131 T/C cg20255094 chr1:160771763 LY9 0.49 6.7 0.35 9.16e-11 Blood protein levels; CRC cis rs12980942 0.810 rs8103839 chr19:41781493 C/G cg25627403 chr19:41769009 HNRNPUL1 0.52 6.02 0.31 4.73e-9 Coronary artery disease; CRC trans rs7299538 1.000 rs7299538 chr12:46085330 C/T cg20672981 chr7:27242161 NA -0.44 -6.03 -0.32 4.43e-9 Gut microbiome composition (winter); CRC cis rs1355223 1.000 rs2221720 chr11:34754921 C/T cg11058730 chr11:34937778 PDHX;APIP 0.49 7.06 0.36 1.02e-11 Systemic lupus erythematosus and Systemic sclerosis; CRC cis rs4604732 0.631 rs34443739 chr1:247626913 A/G cg12754571 chr1:247694271 LOC148824;OR2C3 0.42 5.83 0.31 1.36e-8 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CRC cis rs1865760 1.000 rs6910138 chr6:25904352 C/G cg16482183 chr6:26056742 HIST1H1C 0.55 7.97 0.4 2.55e-14 Height; CRC cis rs769267 0.895 rs1858999 chr19:19497669 C/G cg02546618 chr19:19431379 KIAA0892;SF4 -0.45 -6.22 -0.32 1.54e-9 Tonsillectomy; CRC trans rs35110281 0.715 rs969060 chr21:45080852 T/G cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.53 8.9 0.44 3.69e-17 Mean corpuscular volume; CRC cis rs2115630 0.645 rs4842978 chr15:85197253 T/C cg09876464 chr15:85330779 ZNF592 0.39 6.51 0.34 2.74e-10 P wave terminal force; CRC cis rs7215564 0.908 rs2873059 chr17:78663874 T/C cg09596252 chr17:78655493 RPTOR 0.56 6.11 0.32 2.76e-9 Myopia (pathological); CRC cis rs9291683 0.588 rs35866697 chr4:10018604 C/A cg00071950 chr4:10020882 SLC2A9 0.68 13.12 0.59 6.59e-32 Bone mineral density; CRC trans rs12530266 0.523 rs11154200 chr6:124275316 A/G cg11555228 chr19:21324807 ZNF431 0.41 5.99 0.31 5.41e-9 Gut microbiome composition (summer); CRC cis rs2832191 0.935 rs11910475 chr21:30519702 T/C cg24692254 chr21:30365293 RNF160 -0.62 -10.36 -0.5 5.9e-22 Dental caries; CRC trans rs629535 0.862 rs2178955 chr8:70045303 C/T cg21567404 chr3:27674614 NA 0.95 16.08 0.66 2.35e-43 Dupuytren's disease; CRC cis rs7945705 0.967 rs1569408 chr11:8909732 G/A cg21881798 chr11:8931708 C11orf17;ST5 0.67 10.32 0.49 7.98e-22 Hemoglobin concentration; CRC cis rs2243480 1.000 rs1723267 chr7:65473314 G/A cg12463550 chr7:65579703 CRCP 0.65 6.24 0.33 1.32e-9 Diabetic kidney disease; CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg18313106 chr1:229694614 ABCB10 0.41 6.6 0.34 1.68e-10 Obesity-related traits; CRC cis rs4716602 0.596 rs10253193 chr7:156157801 C/T cg16983916 chr7:156159713 NA -0.39 -7.03 -0.36 1.21e-11 Anti-saccade response; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg18990761 chr12:123756318 CDK2AP1 0.44 6.13 0.32 2.54e-9 Anxiety disorder; CRC cis rs10927875 0.722 rs6660685 chr1:16346988 A/G cg24140574 chr1:16342155 HSPB7 0.42 5.63 0.3 3.96e-8 Dilated cardiomyopathy; CRC cis rs2976388 0.590 rs3736011 chr8:143817789 G/A cg24634471 chr8:143751801 JRK -0.47 -6.66 -0.34 1.16e-10 Urinary tract infection frequency; CRC cis rs17209837 1.000 rs4148815 chr7:87087834 A/T cg00919237 chr7:87102261 ABCB4 -0.49 -6.03 -0.32 4.4e-9 Gallbladder cancer; CRC cis rs1707322 1.000 rs10789486 chr1:46408667 A/G cg03146154 chr1:46216737 IPP 0.49 6.82 0.35 4.34e-11 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs881375 0.967 rs7875829 chr9:123660398 A/G cg09586646 chr9:123605570 PSMD5;LOC253039 0.52 7.15 0.37 5.83e-12 Rheumatoid arthritis; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg26220259 chr1:44444688 B4GALT2 0.39 6.23 0.32 1.39e-9 Liver disease severity in Alagille syndrome; CRC cis rs7726839 0.540 rs72707016 chr5:665148 A/G cg09021430 chr5:549028 NA -0.72 -7.85 -0.4 5.9e-14 Obesity-related traits; CRC cis rs9549328 0.700 rs3011473 chr13:113618096 A/G cg24588162 chr13:113633484 MCF2L 0.37 6.62 0.34 1.46e-10 Systolic blood pressure; CRC cis rs7635838 0.596 rs347599 chr3:11258191 C/T cg00170343 chr3:11313890 ATG7 -0.47 -7.19 -0.37 4.35e-12 HDL cholesterol; CRC cis rs1707322 0.662 rs11211160 chr1:46146229 T/A cg06784218 chr1:46089804 CCDC17 0.64 12.02 0.55 7.86e-28 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs6088580 0.634 rs4911152 chr20:32955024 T/C cg24642439 chr20:33292090 TP53INP2 -0.41 -6.82 -0.35 4.41e-11 Glomerular filtration rate (creatinine); CRC cis rs4563143 0.577 rs73025093 chr19:29254618 T/G cg12667521 chr19:29218732 NA 0.5 7.62 0.39 2.77e-13 Methadone dose in opioid dependence; CRC cis rs524281 0.861 rs7943911 chr11:65943054 G/A cg14036092 chr11:66035641 RAB1B -0.47 -5.71 -0.3 2.54e-8 Electroencephalogram traits; CRC cis rs7811142 0.830 rs73401450 chr7:99981859 G/C cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.96 12.76 0.58 1.47e-30 Platelet count; CRC cis rs7927771 0.832 rs10838699 chr11:47386073 T/C cg18512352 chr11:47633146 NA 0.35 6.91 0.36 2.48e-11 Subjective well-being; CRC cis rs896854 0.967 rs896853 chr8:95960855 G/C cg13393036 chr8:95962371 TP53INP1 -0.55 -9.5 -0.46 4.68e-19 Type 2 diabetes; CRC cis rs1670533 1.000 rs7669399 chr4:1058478 T/G cg27284194 chr4:1044797 NA 0.51 6.44 0.33 4.17e-10 Recombination rate (females); CRC cis rs2625529 0.557 rs1000281 chr15:72553422 A/G cg16672083 chr15:72433130 SENP8 0.44 6.61 0.34 1.51e-10 Red blood cell count; CRC cis rs9469913 0.542 rs114863007 chr6:34729158 G/A cg14254433 chr6:34482411 PACSIN1 -0.68 -5.93 -0.31 7.51e-9 Body mass index (joint analysis main effects and physical activity interaction);Body mass index;Body mass index in physically active individuals; CRC cis rs4713118 0.513 rs149975 chr6:27986340 G/A cg20615401 chr6:28092323 ZSCAN16 0.47 6.32 0.33 8.57e-10 Parkinson's disease; CRC cis rs9549328 0.589 rs36164841 chr13:113616579 A/G cg20742385 chr13:113633654 MCF2L 0.55 9.39 0.46 1.01e-18 Systolic blood pressure; CRC cis rs4824093 0.610 rs74371371 chr22:50314074 C/T cg22709217 chr22:50311962 ALG12;CRELD2 -0.96 -9.24 -0.45 3.06e-18 Amyotrophic lateral sclerosis (sporadic); CRC cis rs7937682 0.889 rs578022 chr11:111490552 G/T cg09085632 chr11:111637200 PPP2R1B -0.98 -19.21 -0.73 1.09e-55 Primary sclerosing cholangitis; CRC cis rs6594499 0.903 rs1438672 chr5:110467753 G/A cg04022379 chr5:110408740 TSLP 0.44 6.74 0.35 7.14e-11 Allergic disease (asthma, hay fever or eczema); CRC cis rs3820068 0.581 rs1547033 chr1:15918988 T/C cg24675056 chr1:15929824 NA 0.49 6.65 0.34 1.23e-10 Systolic blood pressure; CRC cis rs1152591 1.000 rs2738413 chr14:64679960 A/G cg23250157 chr14:64679961 SYNE2 0.49 7.6 0.39 3.02e-13 Atrial fibrillation; CRC cis rs3764563 0.935 rs10408443 chr19:15715973 C/T cg20725493 chr19:15740067 CYP4F8 -0.68 -6.24 -0.33 1.36e-9 Inflammatory biomarkers; CRC cis rs6952808 1.000 rs6953693 chr7:1886388 C/G cg04267008 chr7:1944627 MAD1L1 -0.67 -9.65 -0.47 1.4e-19 Bipolar disorder and schizophrenia; CRC cis rs798554 0.679 rs2527681 chr7:2892384 A/T cg04166393 chr7:2884313 GNA12 0.56 7.67 0.39 1.99e-13 Height; CRC cis rs10971721 0.908 rs10971787 chr9:33914412 A/G cg13495928 chr9:33750294 PRSS3 0.56 5.97 0.31 6.15e-9 Body mass index; CRC cis rs10504229 0.683 rs16921810 chr8:58106067 A/G cg04204079 chr8:58130323 NA -0.46 -5.79 -0.3 1.67e-8 Developmental language disorder (linguistic errors); CRC cis rs11098499 0.954 rs12508504 chr4:120410607 A/C cg24375607 chr4:120327624 NA 0.48 7.57 0.39 3.72e-13 Corneal astigmatism; CRC cis rs270601 0.690 rs162904 chr5:131595784 C/T cg22638593 chr5:131593259 PDLIM4 -0.47 -8.12 -0.41 9.75e-15 Acylcarnitine levels; CRC cis rs9807989 0.507 rs7605284 chr2:103044175 T/G cg03938978 chr2:103052716 IL18RAP 0.59 10.09 0.49 4.82e-21 Asthma; CRC cis rs2197308 0.765 rs10880643 chr12:37926452 C/T cg26384229 chr12:38710491 ALG10B -0.63 -9.63 -0.47 1.65e-19 Morning vs. evening chronotype; CRC cis rs853679 0.517 rs1904840 chr6:28108232 C/T cg23161317 chr6:28129485 ZNF389 0.53 6.43 0.33 4.52e-10 Depression; CRC cis rs28386778 0.897 rs10221279 chr17:61806138 A/G cg11494091 chr17:61959527 GH2 0.61 10.2 0.49 2.05e-21 Prudent dietary pattern; CRC trans rs2797160 1.000 rs2797154 chr6:126005197 A/G cg05039488 chr6:79577232 IRAK1BP1 -0.49 -7.32 -0.37 1.91e-12 Endometrial cancer; CRC cis rs68170813 0.559 rs997311 chr7:106953033 G/A cg02696742 chr7:106810147 HBP1 -0.58 -6.27 -0.33 1.11e-9 Coronary artery disease; CRC cis rs9311474 0.508 rs7652191 chr3:52610415 T/C cg10802521 chr3:52805072 NEK4 -0.58 -9.23 -0.45 3.45e-18 Electroencephalogram traits; CRC cis rs2635047 0.615 rs2684819 chr18:44710691 C/T cg19077165 chr18:44547161 KATNAL2 -0.42 -6.62 -0.34 1.48e-10 Educational attainment; CRC trans rs10242455 0.702 rs73405247 chr7:99159174 C/G cg09045935 chr12:6379348 NA 1.15 8.8 0.44 7.62e-17 Blood metabolite levels; CRC cis rs453301 0.686 rs10217044 chr8:8894752 A/G cg14979609 chr8:8086686 FLJ10661 0.37 6.02 0.32 4.61e-9 Joint mobility (Beighton score); CRC cis rs60733400 0.667 rs4385650 chr1:2499898 G/A cg18854424 chr1:2615690 NA 0.36 6.88 0.35 2.97e-11 Multiple sclerosis; CRC cis rs514406 0.798 rs576650 chr1:53327207 C/T cg24675658 chr1:53192096 ZYG11B -0.65 -9.8 -0.48 4.44e-20 Monocyte count; CRC cis rs17376456 0.877 rs17315943 chr5:93442830 T/C cg25358565 chr5:93447407 FAM172A 1.02 10.47 0.5 2.42e-22 Diabetic retinopathy; CRC cis rs911119 0.908 rs8114619 chr20:23601813 G/T cg16589663 chr20:23618590 CST3 0.47 6.5 0.34 2.92e-10 Chronic kidney disease; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg23350065 chr19:4909600 UHRF1 0.45 6.57 0.34 1.95e-10 Anxiety disorder; CRC cis rs868036 1.000 rs1026732 chr15:68095085 C/T cg05925327 chr15:68127851 NA -0.31 -5.94 -0.31 7.1e-9 Restless legs syndrome; CRC trans rs561341 1.000 rs546519 chr17:30297682 T/G cg20587970 chr11:113659929 NA -1.18 -17.22 -0.69 7.98e-48 Hip circumference adjusted for BMI; CRC cis rs6539288 0.630 rs10778519 chr12:107357329 A/G cg15890332 chr12:107067104 RFX4 0.32 5.64 0.3 3.65e-8 Total body bone mineral density; CRC cis rs2000999 0.514 rs17604662 chr16:72221464 A/G cg04254540 chr16:71951199 KIAA0174 -0.73 -6.24 -0.33 1.38e-9 Total cholesterol levels;Cholesterol, total;Blood protein levels;LDL cholesterol levels;Haptoglobin levels;LDL cholesterol; CRC trans rs9583531 0.628 rs9521914 chr13:111382231 C/A cg20064139 chr20:41823021 NA -0.29 -6.14 -0.32 2.32e-9 Coronary artery disease; CRC cis rs8180040 0.739 rs12488225 chr3:47235107 G/A cg10298567 chr3:47292165 KIF9 -0.4 -6.5 -0.34 2.94e-10 Colorectal cancer; CRC cis rs7095944 0.614 rs4962697 chr10:126447545 G/C cg08799069 chr10:126477246 METTL10 -0.42 -6.45 -0.34 3.91e-10 Asthma; CRC cis rs727505 0.954 rs68102397 chr7:124685315 C/T cg23710748 chr7:124431027 NA -0.79 -13.86 -0.61 9.98e-35 Lewy body disease; CRC cis rs7618501 0.602 rs6780731 chr3:50017478 A/G cg05623727 chr3:50126028 RBM5 0.46 7.55 0.38 4.42e-13 Intelligence (multi-trait analysis); CRC cis rs1143633 0.579 rs4849132 chr2:113673471 G/A cg06771106 chr2:113671356 IL1F7 0.43 6.19 0.32 1.83e-9 Allergic disease (asthma, hay fever or eczema); CRC cis rs2952156 1.000 rs2088126 chr17:37879030 A/G cg11212589 chr17:38028394 ZPBP2 0.34 5.74 0.3 2.13e-8 Asthma; CRC cis rs611744 0.647 rs633901 chr8:109242981 G/T cg18478394 chr8:109455254 TTC35 0.38 5.95 0.31 6.87e-9 Dupuytren's disease; CRC cis rs4713118 0.666 rs2893930 chr6:27738806 T/C cg12273811 chr6:28175739 NA 0.51 5.71 0.3 2.51e-8 Parkinson's disease; CRC cis rs2408955 0.522 rs10875721 chr12:48413593 A/G cg21466736 chr12:48725269 NA 0.49 7.63 0.39 2.51e-13 Glycated hemoglobin levels; CRC cis rs35146811 0.660 rs6465760 chr7:99591418 A/G cg13334819 chr7:99746414 C7orf59 0.42 5.82 0.31 1.38e-8 Coronary artery disease; CRC cis rs9549328 0.589 rs34144481 chr13:113617322 T/G cg20742385 chr13:113633654 MCF2L 0.55 9.27 0.46 2.54e-18 Systolic blood pressure; CRC cis rs2153535 0.580 rs2327058 chr6:8447018 C/T cg21535247 chr6:8435926 SLC35B3 0.5 7.53 0.38 4.92e-13 Motion sickness; CRC cis rs7940866 0.804 rs10894289 chr11:130808685 C/T cg12179176 chr11:130786555 SNX19 0.63 9.28 0.46 2.36e-18 Schizophrenia; CRC cis rs12142240 0.698 rs72679807 chr1:46846490 G/A cg00530320 chr1:46809349 NSUN4 0.59 8.07 0.41 1.35e-14 Menopause (age at onset); CRC cis rs7312774 0.867 rs10492213 chr12:107295841 A/T cg16260113 chr12:107380972 MTERFD3 -0.76 -7.62 -0.39 2.69e-13 Severe influenza A (H1N1) infection; CRC cis rs3087591 0.708 rs1129506 chr17:29646032 G/A cg24425628 chr17:29625626 OMG;NF1 0.67 11.51 0.54 5.44e-26 Hip circumference; CRC cis rs896854 0.654 rs896846 chr8:95972453 G/A cg13393036 chr8:95962371 TP53INP1 -0.54 -9.26 -0.45 2.63e-18 Type 2 diabetes; CRC cis rs2732480 0.577 rs2450994 chr12:48721832 G/A cg04545296 chr12:48745243 ZNF641 0.33 5.66 0.3 3.24e-8 Hemoglobin concentration;Red blood cell count;Hematocrit; CRC cis rs3820068 0.705 rs11583306 chr1:15860803 A/G cg27534772 chr1:16042836 PLEKHM2 -0.41 -6.81 -0.35 4.65e-11 Systolic blood pressure; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg03301945 chr19:10764555 ILF3;LOC147727 0.4 6.02 0.31 4.72e-9 Response to antipsychotic treatment; CRC cis rs11711311 1.000 rs12637066 chr3:113527574 A/G cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.52 -6.99 -0.36 1.51e-11 IgG glycosylation; CRC cis rs1552244 0.515 rs111560858 chr3:10166845 G/A cg02579736 chr3:10068473 FANCD2;CIDECP 1.01 11.66 0.54 1.57e-26 Alzheimer's disease; CRC cis rs1448094 0.791 rs7303256 chr12:86333217 C/T cg00310523 chr12:86230176 RASSF9 -0.43 -7.24 -0.37 3.15e-12 Major depressive disorder; CRC cis rs1656402 1.000 rs3108614 chr2:233425485 T/G cg03852847 chr2:233439513 NA 0.45 7.71 0.39 1.54e-13 Non-small cell lung cancer (survival); CRC cis rs6424115 0.800 rs2229583 chr1:24200983 C/T cg15997130 chr1:24165203 NA 0.73 10.74 0.51 3e-23 Immature fraction of reticulocytes; CRC cis rs28655083 0.509 rs679263 chr16:77103829 T/C cg01753188 chr16:77233325 SYCE1L;MON1B 0.48 6.85 0.35 3.74e-11 Lobe attachment (rater-scored or self-reported); CRC cis rs35306767 0.668 rs12784928 chr10:1083617 A/C cg20503657 chr10:835505 NA 0.66 8.84 0.44 6.03e-17 Eosinophil percentage of granulocytes; CRC cis rs3008870 1.000 rs12740884 chr1:67459855 C/A cg08660285 chr1:67390436 MIER1;WDR78 -1.04 -15.24 -0.64 4.66e-40 Lymphocyte percentage of white cells; CRC cis rs17155006 0.655 rs450722 chr7:107726014 G/A cg05962710 chr7:107745446 LAMB4 -0.35 -5.85 -0.31 1.21e-8 Pneumococcal bacteremia; CRC cis rs11098499 0.954 rs59866101 chr4:120296591 T/G cg09307838 chr4:120376055 NA 0.71 10.93 0.52 6.41e-24 Corneal astigmatism; CRC cis rs501120 0.564 rs2624682 chr10:44678240 C/T cg09554077 chr10:44749378 NA 0.5 6.98 0.36 1.62e-11 Coronary artery disease;Coronary heart disease; CRC trans rs1005277 0.579 rs1780137 chr10:38501475 C/G cg17830980 chr10:43048298 ZNF37B -0.59 -9.71 -0.47 9.16e-20 Extrinsic epigenetic age acceleration; CRC cis rs524281 0.861 rs7937281 chr11:65950074 T/C cg14036092 chr11:66035641 RAB1B -0.45 -5.61 -0.3 4.26e-8 Electroencephalogram traits; CRC trans rs6950442 0.556 rs617433 chr7:114348653 T/G cg08672999 chr19:52675203 ZNF836 -0.54 -6.86 -0.35 3.37e-11 Body mass index; CRC cis rs9309711 0.643 rs4264589 chr2:3481098 G/T cg08493051 chr2:3487164 NA -0.39 -5.73 -0.3 2.28e-8 Neurofibrillary tangles; CRC cis rs9648716 1.000 rs62484301 chr7:140573382 A/T cg10747023 chr7:140774559 NA 0.45 5.82 0.31 1.36e-8 Type 2 diabetes; CRC cis rs12926788 0.640 rs12924246 chr16:24844629 A/G cg06028605 chr16:24865363 SLC5A11 0.6 9.96 0.48 1.3e-20 Ejection fraction in Tripanosoma cruzi seropositivity; CRC cis rs921968 0.541 rs10205073 chr2:219412784 C/A cg02176678 chr2:219576539 TTLL4 -0.58 -9.2 -0.45 4.09e-18 Mean corpuscular hemoglobin concentration; CRC cis rs11098499 0.697 rs28655325 chr4:120372999 A/G cg09307838 chr4:120376055 NA 0.72 11.14 0.52 1.1e-24 Corneal astigmatism; CRC cis rs4319547 0.695 rs113841747 chr12:122886088 G/T cg23029597 chr12:123009494 RSRC2 0.6 7.52 0.38 5.41e-13 Body mass index; CRC cis rs10256972 0.524 rs6945202 chr7:1116558 T/C cg22907277 chr7:1156413 C7orf50 0.59 8.87 0.44 4.9e-17 Longevity;Endometriosis; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg02521036 chr11:62554803 TAF6L;TMEM179B 0.45 6.36 0.33 6.68e-10 Intelligence (multi-trait analysis); CRC trans rs12599106 0.629 rs1391904 chr16:34548934 C/T cg03395511 chr6:291903 DUSP22 -0.5 -6.89 -0.36 2.76e-11 Menopause (age at onset); CRC cis rs7552404 0.628 rs4949686 chr1:76473299 G/C cg10523679 chr1:76189770 ACADM 0.7 8.04 0.41 1.59e-14 Blood metabolite levels;Acylcarnitine levels; CRC cis rs10256972 0.524 rs6945202 chr7:1116558 T/C cg03923535 chr7:1197113 ZFAND2A 0.54 7.64 0.39 2.37e-13 Longevity;Endometriosis; CRC cis rs7927771 0.524 rs10838739 chr11:47672743 A/G cg20307385 chr11:47447363 PSMC3 -0.48 -6.97 -0.36 1.76e-11 Subjective well-being; CRC cis rs2976388 0.587 rs2717606 chr8:143799496 G/A cg15511327 chr8:143859410 LYNX1 0.39 6.85 0.35 3.62e-11 Urinary tract infection frequency; CRC cis rs9322193 0.884 rs9688699 chr6:150054816 A/G cg05861140 chr6:150128134 PCMT1 -0.38 -5.98 -0.31 5.67e-9 Lung cancer; CRC trans rs75804782 0.581 rs72987336 chr2:239365345 T/C cg01134436 chr17:81009848 B3GNTL1 0.7 6.46 0.34 3.8e-10 Morning vs. evening chronotype;Chronotype; CRC cis rs801193 0.613 rs2659900 chr7:66184443 G/C cg00343986 chr7:65444356 GUSB 0.43 6.16 0.32 2.18e-9 Aortic root size; CRC cis rs2549003 1.000 rs6894655 chr5:131818649 T/C cg21138405 chr5:131827807 IRF1 0.57 11.33 0.53 2.39e-25 Asthma (sex interaction); CRC cis rs9787249 0.957 rs12239844 chr1:40217258 T/C cg24920358 chr1:40204285 PPIE 0.58 8.95 0.44 2.66e-17 Blood protein levels; CRC cis rs1499614 1.000 rs2707840 chr7:66158015 C/T cg25985355 chr7:65971099 NA -0.52 -5.92 -0.31 7.91e-9 Gout; CRC cis rs3091242 0.933 rs926438 chr1:25753638 C/T cg23205692 chr1:25664452 TMEM50A 0.42 6.01 0.31 4.83e-9 Erythrocyte sedimentation rate; CRC cis rs11190604 1.000 rs9420797 chr10:102331147 C/T cg07080220 chr10:102295463 HIF1AN 0.46 5.93 0.31 7.66e-9 Palmitoleic acid (16:1n-7) levels; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg15564865 chr6:4021423 PRPF4B 0.51 6.77 0.35 5.87e-11 Thyroid stimulating hormone; CRC cis rs67478160 0.609 rs1547604 chr14:104270659 A/T cg01849466 chr14:104193079 ZFYVE21 -0.53 -9.84 -0.48 3.32e-20 Schizophrenia; CRC cis rs9325144 0.600 rs7965877 chr12:38743697 G/T cg13010199 chr12:38710504 ALG10B 0.39 5.82 0.31 1.43e-8 Morning vs. evening chronotype; CRC cis rs4853012 0.941 rs4852329 chr2:74354544 A/G cg20891558 chr2:74357851 NA 0.71 10.48 0.5 2.38e-22 Gestational age at birth (maternal effect); CRC cis rs10189230 0.967 rs13026380 chr2:222352715 G/A cg14652038 chr2:222343519 EPHA4 0.52 10.09 0.49 4.79e-21 Urate levels in lean individuals; CRC trans rs7267979 0.966 rs2257705 chr20:25264664 T/C cg17903999 chr18:56338584 MALT1 -0.41 -6.82 -0.35 4.4e-11 Liver enzyme levels (alkaline phosphatase); CRC cis rs2120019 0.938 rs35911108 chr15:75322179 G/A cg09165964 chr15:75287851 SCAMP5 -0.86 -13.39 -0.59 5.93e-33 Blood trace element (Zn levels); CRC cis rs6860806 0.507 rs270608 chr5:131648406 C/T cg04518342 chr5:131593106 PDLIM4 0.46 7.29 0.37 2.36e-12 Breast cancer; CRC cis rs8067545 0.636 rs11204300 chr17:20195438 C/T cg13482628 chr17:19912719 NA -0.48 -7.59 -0.39 3.31e-13 Schizophrenia; CRC cis rs1044826 0.642 rs7624321 chr3:139220159 C/A cg00490450 chr3:139108681 COPB2 0.43 6.43 0.33 4.53e-10 Obesity-related traits; CRC cis rs868036 1.000 rs4325504 chr15:68055570 A/G cg05925327 chr15:68127851 NA 0.29 5.65 0.3 3.5e-8 Restless legs syndrome; CRC cis rs1008375 1.000 rs2109522 chr4:17658645 T/A cg04450456 chr4:17643702 FAM184B 0.41 6.65 0.34 1.25e-10 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs477692 0.673 rs556253 chr10:131355781 G/A cg05714579 chr10:131428358 MGMT 0.47 6.67 0.35 1.07e-10 Response to temozolomide; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg04931582 chr4:140477720 SETD7 0.42 6.56 0.34 2.09e-10 Liver disease severity in Alagille syndrome; CRC cis rs1697139 0.583 rs11739587 chr5:66540481 A/C cg11553311 chr5:66541588 NA -0.56 -9.93 -0.48 1.74e-20 Breast cancer; CRC cis rs10256972 0.577 rs4999286 chr7:1199506 C/G cg23978390 chr7:1156363 C7orf50 0.53 7.44 0.38 8.8e-13 Longevity;Endometriosis; CRC cis rs8077889 1.000 rs8077889 chr17:41878166 G/T cg25876840 chr17:41920477 NA -0.51 -7.26 -0.37 2.84e-12 Triglycerides; CRC cis rs6570726 0.935 rs447247 chr6:145812678 G/T cg23711669 chr6:146136114 FBXO30 0.67 11.98 0.55 1.13e-27 Lobe attachment (rater-scored or self-reported); CRC cis rs11098499 0.863 rs6858777 chr4:120475966 A/G cg24375607 chr4:120327624 NA 0.48 7.24 0.37 3.2e-12 Corneal astigmatism; CRC cis rs728616 0.614 rs61859196 chr10:82109048 A/G cg11900509 chr10:81946545 ANXA11 -0.56 -6.38 -0.33 5.97e-10 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs7258465 0.965 rs7254249 chr19:18591745 G/A cg06462663 chr19:18546047 ISYNA1 0.48 7.39 0.38 1.21e-12 Breast cancer; CRC cis rs6662572 0.950 rs111971542 chr1:46235998 A/T cg08644498 chr1:46502608 NA 0.44 6.12 0.32 2.69e-9 Blood protein levels; CRC cis rs17376456 0.825 rs13164315 chr5:93147421 A/G cg25358565 chr5:93447407 FAM172A 1.0 9.8 0.48 4.7e-20 Diabetic retinopathy; CRC cis rs2836974 0.932 rs56306759 chr21:40608106 G/A cg06238570 chr21:40685208 BRWD1 0.78 10.89 0.51 8.51e-24 Cognitive function; CRC cis rs12024301 0.557 rs114508153 chr1:183632551 A/T cg11505048 chr1:183622726 RGL1;APOBEC4 0.78 6.96 0.36 1.86e-11 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs3015497 0.789 rs3015498 chr14:51112824 T/C cg09863266 chr14:51125203 SAV1 -0.31 -5.77 -0.3 1.82e-8 Mean platelet volume; CRC cis rs9462846 0.960 rs10807284 chr6:42868133 C/A cg21280719 chr6:42927975 GNMT -0.33 -6.49 -0.34 3.09e-10 Blood protein levels; CRC trans rs925098 0.577 rs2724470 chr4:17996046 A/G cg22719782 chr11:114310057 REXO2 -0.45 -6.51 -0.34 2.76e-10 Birth weight;Height; CRC cis rs2842992 0.789 rs4709376 chr6:160226337 A/G cg16489826 chr6:160211363 TCP1;MRPL18 0.49 6.1 0.32 2.97e-9 Age-related macular degeneration (geographic atrophy); CRC cis rs9322193 0.772 rs7738696 chr6:150170121 A/G cg00933542 chr6:150070202 PCMT1 0.32 6.57 0.34 1.98e-10 Lung cancer; CRC cis rs727505 0.909 rs7810427 chr7:124645103 C/T cg23710748 chr7:124431027 NA -0.81 -14.26 -0.62 2.88e-36 Lewy body disease; CRC cis rs3823572 0.564 rs2346276 chr7:133664901 G/T cg03336402 chr7:133662267 EXOC4 -0.66 -10.38 -0.5 5.04e-22 Intelligence (multi-trait analysis); CRC cis rs853679 1.000 rs1936365 chr6:28268452 C/G cg21251018 chr6:28226885 NKAPL -0.48 -5.86 -0.31 1.1e-8 Depression; CRC cis rs9462846 1.000 rs9471950 chr6:42869040 G/A cg21280719 chr6:42927975 GNMT -0.34 -5.89 -0.31 9.37e-9 Blood protein levels; CRC cis rs274567 0.602 rs272853 chr5:131688561 A/G cg02033258 chr5:131593261 PDLIM4 0.35 6.15 0.32 2.25e-9 Blood metabolite levels; CRC cis rs1580019 0.587 rs7806113 chr7:32553084 A/G cg07520158 chr7:32535189 LSM5;AVL9 0.53 7.87 0.4 5.26e-14 Cognitive ability; CRC cis rs977987 0.806 rs11149833 chr16:75464002 G/C cg03315344 chr16:75512273 CHST6 0.55 9.12 0.45 7.56e-18 Dupuytren's disease; CRC cis rs881375 0.967 rs1930781 chr9:123687834 G/A cg00246817 chr9:123691163 NA -0.44 -5.65 -0.3 3.44e-8 Rheumatoid arthritis; CRC cis rs11764590 0.756 rs17132130 chr7:2108036 G/C cg02951883 chr7:2050386 MAD1L1 0.41 5.61 0.3 4.38e-8 Neuroticism; CRC cis rs2011503 0.943 rs4239639 chr19:19435876 G/A cg11584989 chr19:19387371 SF4 -0.55 -6.37 -0.33 6.35e-10 Bipolar disorder; CRC cis rs8072100 0.840 rs4968319 chr17:45464967 A/G cg08085267 chr17:45401833 C17orf57 -0.66 -10.89 -0.51 8.55e-24 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs2304069 1.000 rs7737689 chr5:149396159 C/A cg22760475 chr5:149380129 HMGXB3;TIGD6 0.64 8.11 0.41 9.84e-15 HIV-1 control; CRC cis rs11098499 0.908 rs11729050 chr4:120300066 T/C cg24375607 chr4:120327624 NA 0.51 7.86 0.4 5.5e-14 Corneal astigmatism; CRC cis rs9393777 0.513 rs926300 chr6:27059443 A/T cg12292205 chr6:26970375 C6orf41 -0.79 -8.63 -0.43 2.67e-16 Intelligence (multi-trait analysis); CRC cis rs7043114 0.507 rs10761154 chr9:95144086 A/G cg13798575 chr9:95087839 CENPP;NOL8 -0.4 -5.98 -0.31 5.7e-9 Height; CRC cis rs2882667 0.690 rs288009 chr5:138228662 G/A cg09476006 chr5:138032270 NA 0.55 9.14 0.45 6.76e-18 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs12431939 0.598 rs8012074 chr14:51732101 C/G cg23942311 chr14:51606299 NA 0.49 6.56 0.34 2.07e-10 Cancer; CRC cis rs4713118 0.824 rs9468223 chr6:27740666 C/T cg20933634 chr6:27740509 NA 0.65 9.15 0.45 5.95e-18 Parkinson's disease; CRC cis rs9443645 0.901 rs10943612 chr6:79698380 C/T cg09184832 chr6:79620586 NA -0.51 -9.28 -0.46 2.3e-18 Intelligence (multi-trait analysis); CRC cis rs7512552 0.839 rs834236 chr1:150362968 C/T cg15654264 chr1:150340011 RPRD2 0.59 8.65 0.43 2.26e-16 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); CRC cis rs2811415 0.569 rs9829877 chr3:127787969 A/T cg13719885 chr3:127795394 NA -0.39 -5.95 -0.31 6.69e-9 Lung function (FEV1/FVC); CRC cis rs7119 0.717 rs11632729 chr15:77722006 G/A cg05673287 chr15:77411982 SGK269 -0.51 -7.99 -0.4 2.34e-14 Type 2 diabetes; CRC cis rs910316 0.763 rs12588981 chr14:75460561 A/G cg11812906 chr14:75593930 NEK9 0.56 8.51 0.42 6.33e-16 Height; CRC cis rs67311347 1.000 rs7631893 chr3:40440869 C/T cg09455208 chr3:40491958 NA 0.4 8.14 0.41 8.41e-15 Renal cell carcinoma; CRC cis rs7224737 1.000 rs8074708 chr17:40286354 A/G cg00647820 chr17:40259828 DHX58 0.45 6.43 0.33 4.38e-10 Fibrinogen levels; CRC cis rs524281 0.861 rs11227411 chr11:65879478 C/T cg16950941 chr11:66035639 RAB1B -0.6 -7.39 -0.38 1.25e-12 Electroencephalogram traits; CRC cis rs600231 0.708 rs1784860 chr11:65240712 C/A cg17120908 chr11:65337727 SSSCA1 -0.55 -8.24 -0.41 4.13e-15 Bone mineral density; CRC cis rs4332037 0.707 rs62435132 chr7:1891315 C/T cg13880726 chr7:1868755 MAD1L1 -0.42 -5.66 -0.3 3.31e-8 Bipolar disorder; CRC cis rs2692947 0.644 rs1168970 chr2:96816606 C/T cg23100626 chr2:96804247 ASTL 0.3 7.98 0.4 2.46e-14 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; CRC cis rs9611565 0.625 rs73178625 chr22:41928320 G/C cg06481639 chr22:41940642 POLR3H -0.5 -5.79 -0.3 1.62e-8 Vitiligo; CRC cis rs7705042 0.828 rs6877864 chr5:141503839 A/G cg08523384 chr5:141488047 NDFIP1 -0.33 -5.83 -0.31 1.31e-8 Asthma; CRC cis rs9372498 0.536 rs9320660 chr6:118956827 A/T cg01339444 chr6:118972232 C6orf204 0.54 5.98 0.31 5.97e-9 Diastolic blood pressure; CRC cis rs28595532 1.000 rs11098451 chr4:119717673 C/T cg21605333 chr4:119757512 SEC24D 0.77 5.87 0.31 1.07e-8 Cannabis dependence symptom count; CRC cis rs9487051 1.000 rs9400273 chr6:109632799 A/G cg12927641 chr6:109611667 NA -0.33 -5.6 -0.3 4.52e-8 Reticulocyte fraction of red cells; CRC cis rs6456156 0.586 rs13208636 chr6:167461965 T/G cg07741184 chr6:167504864 NA 0.39 6.9 0.36 2.63e-11 Primary biliary cholangitis; CRC cis rs12971120 0.891 rs71359051 chr18:72169723 G/A cg26446133 chr18:72167187 CNDP2 -0.74 -11.13 -0.52 1.21e-24 Refractive error; CRC cis rs2976388 1.000 rs2976394 chr8:143763622 C/T cg24046110 chr8:143859143 LYNX1 -0.37 -6.32 -0.33 8.7e-10 Urinary tract infection frequency; CRC cis rs477895 0.568 rs34838337 chr11:63870892 T/C cg01518246 chr11:63870912 FLRT1;MACROD1 0.45 6.21 0.32 1.57e-9 Mean platelet volume; CRC cis rs6495367 0.803 rs2870111 chr15:79403585 C/T cg17916960 chr15:79447300 NA 0.43 6.96 0.36 1.82e-11 Spherical equivalent (joint analysis main effects and education interaction); CRC cis rs8058578 1.000 rs67456513 chr16:30714828 A/T cg02466173 chr16:30829666 NA -0.67 -9.87 -0.48 2.79e-20 Multiple myeloma; CRC cis rs2153535 0.580 rs1932275 chr6:8442333 T/A cg21535247 chr6:8435926 SLC35B3 0.48 7.24 0.37 3.19e-12 Motion sickness; CRC cis rs6951245 0.872 rs77569514 chr7:1085508 G/A cg22907277 chr7:1156413 C7orf50 0.71 7.38 0.38 1.32e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs4713118 0.587 rs61471148 chr6:28037032 T/A cg25164649 chr6:28176230 NA 0.7 8.85 0.44 5.59e-17 Parkinson's disease; CRC cis rs2019137 0.936 rs4849169 chr2:113953657 A/C cg19083407 chr2:113993142 PAX8;LOC440839;LOC654433 -0.47 -6.56 -0.34 2.04e-10 Lymphocyte counts; CRC cis rs875971 0.825 rs4587224 chr7:65736182 G/A cg12463550 chr7:65579703 CRCP -0.53 -7.42 -0.38 9.97e-13 Aortic root size; CRC cis rs12900413 0.562 rs2118849 chr15:90302399 G/T cg24249390 chr15:90295951 MESP1 -0.61 -9.38 -0.46 1.15e-18 Coronary artery aneurysm in Kawasaki disease; CRC cis rs4713118 0.505 rs276371 chr6:27910708 A/T cg03623178 chr6:28175578 NA 0.61 8.65 0.43 2.24e-16 Parkinson's disease; CRC cis rs10254118 0.757 rs7788086 chr7:133135206 C/T cg10665199 chr7:133106180 EXOC4 0.67 10.32 0.49 8.44e-22 Intelligence (multi-trait analysis); CRC cis rs798554 0.759 rs2644291 chr7:2890456 T/C cg04166393 chr7:2884313 GNA12 0.56 7.34 0.38 1.67e-12 Height; CRC cis rs2721195 0.719 rs4925811 chr8:145802447 G/T cg11211951 chr8:145729740 GPT -0.48 -8.65 -0.43 2.39e-16 Age at first birth; CRC cis rs35110281 0.840 rs2838331 chr21:45026728 A/G cg01579765 chr21:45077557 HSF2BP 0.41 7.99 0.4 2.33e-14 Mean corpuscular volume; CRC cis rs11583043 0.546 rs6688545 chr1:101590335 G/A cg16556008 chr1:101360663 SLC30A7;EXTL2 0.46 5.96 0.31 6.63e-9 Ulcerative colitis;Inflammatory bowel disease; CRC cis rs7843479 0.582 rs7818254 chr8:21798316 C/T cg17168535 chr8:21777572 XPO7 0.64 10.95 0.52 5.16e-24 Mean corpuscular volume; CRC cis rs8180040 0.620 rs11917361 chr3:47070497 G/T cg10298567 chr3:47292165 KIF9 0.37 5.64 0.3 3.75e-8 Colorectal cancer; CRC cis rs2932538 0.883 rs7549547 chr1:113086717 A/T cg22162597 chr1:113214053 CAPZA1 0.69 9.79 0.47 5.06e-20 Systolic blood pressure;Diastolic blood pressure;Hypertension;Blood pressure; CRC cis rs13315871 0.858 rs4075404 chr3:58411419 C/T cg20936604 chr3:58311152 NA -0.76 -7.15 -0.37 5.74e-12 Cholesterol, total; CRC cis rs9372498 0.536 rs9489447 chr6:118900846 G/A cg24463073 chr6:118973353 C6orf204 0.51 6.83 0.35 4.16e-11 Diastolic blood pressure; CRC cis rs1881797 1.000 rs10925062 chr1:247658978 G/C cg21399703 chr1:247681439 NA 0.49 7.62 0.39 2.71e-13 Acute lymphoblastic leukemia (childhood); CRC cis rs875971 1.000 rs9986696 chr7:65704576 C/A cg11764359 chr7:65958608 NA -0.62 -9.96 -0.48 1.35e-20 Aortic root size; CRC cis rs4713118 0.513 rs156734 chr6:28007357 A/C cg20615401 chr6:28092323 ZSCAN16 0.45 6.09 0.32 3.06e-9 Parkinson's disease; CRC cis rs1451375 0.794 rs11238133 chr7:50542914 A/C cg14593290 chr7:50529359 DDC -0.56 -7.64 -0.39 2.45e-13 Malaria; CRC cis rs939574 0.512 rs6730612 chr2:220146196 G/T cg00496455 chr2:220118770 TUBA4A;TUBA4B 0.52 6.04 0.32 4.21e-9 Platelet distribution width; CRC cis rs9911578 1.000 rs10401050 chr17:56953786 A/C cg12560992 chr17:57184187 TRIM37 0.92 17.0 0.68 6.03e-47 Intelligence (multi-trait analysis); CRC trans rs916888 0.821 rs199504 chr17:44861003 C/T cg23590916 chr17:43697445 MGC57346 -0.57 -6.14 -0.32 2.35e-9 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs9462846 1.000 rs9471950 chr6:42869040 G/A cg10862848 chr6:42927986 GNMT -0.3 -5.64 -0.3 3.62e-8 Blood protein levels; CRC cis rs7617480 0.544 rs6442129 chr3:48735256 T/C cg07636037 chr3:49044803 WDR6 0.71 8.88 0.44 4.56e-17 Subjective well-being (multi-trait analysis);Menarche (age at onset); CRC cis rs9457247 0.765 rs12212247 chr6:167413539 T/C cg23791538 chr6:167370224 RNASET2 -0.39 -5.89 -0.31 9.73e-9 Crohn's disease; CRC cis rs4665809 1.000 rs2289022 chr2:26350136 G/T cg27170947 chr2:26402098 FAM59B -0.46 -6.1 -0.32 2.93e-9 Gut microbiome composition (summer); CRC cis rs10504229 1.000 rs60454728 chr8:58173781 G/A cg02725872 chr8:58115012 NA -0.38 -6.43 -0.33 4.44e-10 Developmental language disorder (linguistic errors); CRC cis rs11711311 1.000 rs12637067 chr3:113527606 A/G cg15478005 chr3:113465772 ATP6V1A;NAA50 0.43 5.96 0.31 6.36e-9 IgG glycosylation; CRC cis rs11650494 0.710 rs11653775 chr17:47472365 A/G cg08112188 chr17:47440006 ZNF652 0.67 5.99 0.31 5.63e-9 Prostate cancer; CRC trans rs11088226 0.645 rs78172258 chr21:33936539 T/G cg09050820 chr6:167586206 TCP10L2 0.81 8.48 0.42 7.74e-16 Gastritis; CRC cis rs600231 0.542 rs12360896 chr11:65238306 G/T cg17120908 chr11:65337727 SSSCA1 -0.68 -7.56 -0.38 4.09e-13 Bone mineral density; CRC cis rs1552244 0.935 rs41520445 chr3:10153141 A/C cg18598329 chr3:10140678 FANCD2;C3orf24 0.88 11.73 0.54 8.6e-27 Alzheimer's disease; CRC cis rs12928939 0.637 rs8046629 chr16:71643116 G/A cg08717414 chr16:71523259 ZNF19 -0.47 -5.71 -0.3 2.47e-8 Post bronchodilator FEV1; CRC cis rs698833 0.798 rs1067391 chr2:44639434 T/G cg04920474 chr2:44395004 PPM1B 0.4 5.96 0.31 6.35e-9 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; CRC cis rs6502050 0.765 rs6502074 chr17:80121776 T/C cg13198984 chr17:80129470 CCDC57 0.44 7.73 0.39 1.34e-13 Life satisfaction; CRC trans rs1499614 0.901 rs3936 chr7:66126489 C/T cg10756647 chr7:56101905 PSPH 0.76 8.08 0.41 1.26e-14 Gout; CRC cis rs2652834 0.718 rs2729829 chr15:63395484 C/T cg05507819 chr15:63340323 TPM1 0.43 5.65 0.3 3.46e-8 HDL cholesterol; CRC cis rs1552244 1.000 rs6786638 chr3:10118075 G/C cg18598329 chr3:10140678 FANCD2;C3orf24 -0.87 -11.82 -0.55 4.24e-27 Alzheimer's disease; CRC trans rs7395662 0.713 rs2865668 chr11:48745046 T/C cg21153622 chr11:89784906 NA -0.51 -8.11 -0.41 1.04e-14 HDL cholesterol; CRC cis rs9486715 0.659 rs9399930 chr6:96854444 G/T cg06623918 chr6:96969491 KIAA0776 0.93 16.26 0.67 4.71e-44 Headache; CRC cis rs1044826 0.642 rs167187 chr3:139237008 C/T cg00490450 chr3:139108681 COPB2 -0.45 -6.76 -0.35 6.31e-11 Obesity-related traits; CRC cis rs921968 0.643 rs579610 chr2:219327582 C/A cg02176678 chr2:219576539 TTLL4 0.48 8.0 0.4 2.1e-14 Mean corpuscular hemoglobin concentration; CRC cis rs6502050 0.835 rs28481866 chr17:80105160 G/A cg25804541 chr17:80189381 SLC16A3 -0.31 -5.97 -0.31 6.08e-9 Life satisfaction; CRC cis rs950169 0.579 rs12912716 chr15:84664263 A/T cg11189052 chr15:85197271 WDR73 0.55 7.32 0.37 1.88e-12 Schizophrenia; CRC cis rs9847710 1.000 rs2581817 chr3:53071797 G/C cg04503182 chr3:53078218 SFMBT1 0.44 7.05 0.36 1.06e-11 Ulcerative colitis; CRC trans rs11039798 0.764 rs76882342 chr11:48939091 A/T cg03929089 chr4:120376271 NA 0.64 6.1 0.32 2.95e-9 Axial length; CRC cis rs875971 0.571 rs160641 chr7:65577346 G/A cg02869306 chr7:64672164 INTS4L1 0.43 6.3 0.33 9.49e-10 Aortic root size; CRC cis rs977987 0.843 rs11641801 chr16:75455448 A/C cg03315344 chr16:75512273 CHST6 0.54 9.24 0.45 3.17e-18 Dupuytren's disease; CRC trans rs2303319 0.504 rs1449641 chr2:162619567 T/C cg09481857 chr22:21368659 P2RX6;MGC16703 -0.64 -6.28 -0.33 1.08e-9 Cognitive function; CRC cis rs9942416 0.660 rs61173369 chr5:74997995 A/G cg19683494 chr5:74908142 NA 0.48 6.2 0.32 1.74e-9 Age-related disease endophenotypes; CRC trans rs2403907 0.758 rs2823132 chr21:16568856 T/C cg00407105 chr4:90231041 NA -0.4 -6.11 -0.32 2.8e-9 Breast cancer; CRC cis rs59918340 0.728 rs59172574 chr8:142231945 C/G cg17298326 chr8:142245477 NA -0.38 -5.79 -0.3 1.61e-8 Immature fraction of reticulocytes; CRC cis rs13082711 0.911 rs2371065 chr3:27494589 A/C cg02860705 chr3:27208620 NA 0.63 8.91 0.44 3.63e-17 Systolic blood pressure;Diastolic blood pressure;Blood pressure; CRC cis rs3806843 0.706 rs2563302 chr5:140079051 T/C cg19875535 chr5:140030758 IK -0.62 -10.34 -0.5 6.92e-22 Depressive symptoms (multi-trait analysis); CRC cis rs807669 0.544 rs2040771 chr22:19161935 C/T cg02655711 chr22:19163373 SLC25A1 0.59 9.71 0.47 8.87e-20 Metabolite levels; CRC cis rs853679 1.000 rs853685 chr6:28288785 C/T cg15845792 chr6:28175446 NA 0.58 5.94 0.31 7.09e-9 Depression; CRC cis rs5750830 0.649 rs6001588 chr22:39819049 G/C cg25956985 chr22:39795188 MAP3K7IP1 -0.46 -6.5 -0.34 2.96e-10 Intelligence (multi-trait analysis); CRC cis rs995000 0.899 rs10889340 chr1:63012071 A/C cg19896129 chr1:63156450 NA -0.44 -6.82 -0.35 4.3e-11 Triglyceride levels; CRC cis rs2976388 0.573 rs1529865 chr8:143789171 C/T cg04969067 chr8:143858791 LYNX1 0.45 7.67 0.39 1.97e-13 Urinary tract infection frequency; CRC cis rs763014 0.932 rs2269559 chr16:682297 T/C cg09263875 chr16:632152 PIGQ 0.8 12.76 0.58 1.4e-30 Height; CRC cis rs6545883 0.894 rs9677047 chr2:61585295 C/G cg15711740 chr2:61764176 XPO1 0.43 5.69 0.3 2.76e-8 Tuberculosis; CRC cis rs2153535 0.580 rs1335628 chr6:8491742 A/T cg07606381 chr6:8435919 SLC35B3 0.67 10.78 0.51 2.07e-23 Motion sickness; CRC cis rs7617773 0.817 rs17786132 chr3:48249420 C/G cg11946769 chr3:48343235 NME6 0.72 9.67 0.47 1.22e-19 Coronary artery disease; CRC cis rs28386778 0.897 rs4968599 chr17:61835992 T/C cg25654072 chr17:61904446 PSMC5;FTSJ3 0.73 11.3 0.53 2.96e-25 Prudent dietary pattern; CRC cis rs6121246 0.567 rs6060260 chr20:30192907 C/T cg13852791 chr20:30311386 BCL2L1 0.6 8.21 0.41 5.04e-15 Mean corpuscular hemoglobin; CRC cis rs1448094 0.935 rs11117119 chr12:86336432 A/T cg18827107 chr12:86230957 RASSF9 -0.38 -6.25 -0.33 1.3e-9 Major depressive disorder; CRC cis rs9467773 0.844 rs2393669 chr6:26503873 C/T cg09904177 chr6:26538194 HMGN4 0.85 14.75 0.63 3.95e-38 Intelligence (multi-trait analysis); CRC cis rs8031584 0.678 rs4779496 chr15:31151054 A/G cg08704250 chr15:31115839 NA -0.56 -9.86 -0.48 2.86e-20 Huntington's disease progression; CRC cis rs17818399 0.547 rs4953400 chr2:46777208 T/A cg21681030 chr2:46777652 RHOQ 0.41 5.77 0.3 1.88e-8 Height; CRC cis rs9039 1.000 rs9921107 chr16:9219845 G/T cg08831531 chr16:9218945 NA -0.64 -9.0 -0.44 1.84e-17 Menopause (age at onset); CRC cis rs9914544 1.000 rs8066385 chr17:18761133 C/T cg26378065 chr17:18585709 ZNF286B 0.43 5.87 0.31 1.09e-8 Educational attainment (years of education); CRC cis rs10504229 0.683 rs56196593 chr8:58141898 G/A cg02290350 chr8:58132656 NA -0.57 -8.04 -0.41 1.59e-14 Developmental language disorder (linguistic errors); CRC cis rs10208940 0.920 rs6714976 chr2:68764873 G/T cg12452813 chr2:68675892 NA 0.48 6.01 0.31 4.94e-9 Urate levels in lean individuals; CRC cis rs73206853 0.841 rs3026456 chr12:110748735 G/C cg12870014 chr12:110450643 ANKRD13A 0.8 7.76 0.39 1.1e-13 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC cis rs4711350 0.765 rs6921772 chr6:33749686 A/G cg07979401 chr6:33739406 LEMD2 -0.46 -5.98 -0.31 5.72e-9 Schizophrenia; CRC cis rs4901869 0.966 rs425764 chr14:59334997 A/G cg02291164 chr14:59296302 NA 0.36 6.52 0.34 2.58e-10 Panic disorder; CRC cis rs7945705 0.692 rs11042149 chr11:9010737 T/C cg21881798 chr11:8931708 C11orf17;ST5 -0.68 -11.84 -0.55 3.39e-27 Hemoglobin concentration; CRC cis rs6840360 0.642 rs2709838 chr4:152371364 G/A cg09659197 chr4:152720779 NA 0.33 6.46 0.34 3.69e-10 Intelligence (multi-trait analysis); CRC cis rs11098499 0.722 rs1814814 chr4:120258124 C/G cg09307838 chr4:120376055 NA 0.69 11.12 0.52 1.34e-24 Corneal astigmatism; CRC cis rs7149337 0.805 rs71422017 chr14:51612417 A/T cg18683604 chr14:51561293 TRIM9 0.29 6.0 0.31 5.11e-9 Cancer; CRC cis rs3099143 1.000 rs2046415 chr15:77085253 A/G cg21673338 chr15:77095150 SCAPER -0.73 -7.53 -0.38 4.81e-13 Recalcitrant atopic dermatitis; CRC cis rs116095464 0.558 rs6878061 chr5:223072 A/G cg22857025 chr5:266934 NA -1.23 -16.9 -0.68 1.4300000000000001e-46 Breast cancer; CRC cis rs1355223 0.583 rs2915178 chr11:34878051 C/T cg11058730 chr11:34937778 PDHX;APIP 0.72 11.57 0.54 3.37e-26 Systemic lupus erythematosus and Systemic sclerosis; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg12679910 chr17:73900713 MRPL38 0.44 6.29 0.33 1.04e-9 Intelligence (multi-trait analysis); CRC cis rs6582630 0.548 rs8189608 chr12:38327775 T/G cg26384229 chr12:38710491 ALG10B -0.5 -7.24 -0.37 3.16e-12 Drug-induced liver injury (flucloxacillin); CRC trans rs1814175 0.781 rs12286395 chr11:49954062 C/G cg21153622 chr11:89784906 NA -0.37 -6.03 -0.32 4.33e-9 Height; CRC cis rs6502050 0.835 rs12450189 chr17:80095128 A/C cg13198984 chr17:80129470 CCDC57 0.46 8.16 0.41 6.94e-15 Life satisfaction; CRC cis rs8180040 0.620 rs17784127 chr3:47061700 T/C cg02527881 chr3:46936655 PTH1R 0.33 5.64 0.3 3.75e-8 Colorectal cancer; CRC cis rs747650 0.504 rs4394802 chr11:46990587 C/T cg19486271 chr11:47235900 DDB2 -0.43 -6.51 -0.34 2.76e-10 Acne (severe); CRC cis rs7258465 1.000 rs4808133 chr19:18608518 C/A cg01065977 chr19:18549689 ISYNA1 -0.41 -6.43 -0.33 4.42e-10 Breast cancer; CRC cis rs72772090 0.539 rs11738810 chr5:96119055 T/C cg17330273 chr5:96107758 CAST;ERAP1 -0.63 -5.77 -0.3 1.79e-8 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs9914988 0.943 rs9894335 chr17:27138483 C/A cg07195577 chr17:27052828 TLCD1 0.42 5.99 0.31 5.47e-9 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs933688 1.000 rs12654787 chr5:90713259 C/T cg02339078 chr5:90679543 LOC100129716;ARRDC3 0.92 13.87 0.61 9.28e-35 Smoking behavior; CRC cis rs523522 0.962 rs3759394 chr12:120933173 C/A cg12219531 chr12:120966889 COQ5 0.69 9.31 0.46 1.85e-18 High light scatter reticulocyte count; CRC cis rs2806561 0.606 rs10917335 chr1:23294136 A/G cg12483005 chr1:23474871 LUZP1 0.44 6.39 0.33 5.6e-10 Height; CRC cis rs12692738 0.526 rs355852 chr2:165626304 C/A cg03182029 chr2:165697222 COBLL1 0.5 5.86 0.31 1.11e-8 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);Waist-to-hip ratio adjusted for BMI in non-smokers;Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction);Waist-to-hip ratio adjusted for body mass index; CRC cis rs853679 0.517 rs9357065 chr6:28129580 T/C cg12963246 chr6:28129442 ZNF389 0.5 5.73 0.3 2.3e-8 Depression; CRC cis rs10504229 1.000 rs76023408 chr8:58193345 A/G cg02290350 chr8:58132656 NA -0.44 -6.24 -0.33 1.36e-9 Developmental language disorder (linguistic errors); CRC cis rs6951245 1.000 rs78158942 chr7:1090440 G/T cg18402987 chr7:1209562 NA 0.65 6.8 0.35 4.82e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs4711350 1.000 rs2395401 chr6:33759471 T/C cg07979401 chr6:33739406 LEMD2 -0.47 -5.89 -0.31 9.29e-9 Schizophrenia; CRC cis rs11190604 1.000 rs11292 chr10:102313607 A/G cg07080220 chr10:102295463 HIF1AN 0.48 6.03 0.32 4.38e-9 Palmitoleic acid (16:1n-7) levels; CRC cis rs4713118 0.955 rs34752872 chr6:27683244 A/T cg19041857 chr6:27730383 NA -0.44 -5.99 -0.31 5.36e-9 Parkinson's disease; CRC cis rs58235267 0.553 rs11890276 chr2:63366191 C/T cg17519650 chr2:63277830 OTX1 0.47 6.76 0.35 6.18e-11 Prostate-specific antigen levels (conditioned on lead SNPs); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg07393655 chr5:43122148 ZNF131 0.43 6.11 0.32 2.75e-9 Intelligence (multi-trait analysis); CRC cis rs62064224 0.589 rs9903650 chr17:30689370 T/A cg25809561 chr17:30822961 MYO1D 0.52 9.16 0.45 5.75e-18 Schizophrenia; CRC cis rs9372498 0.536 rs9489409 chr6:118802721 A/G cg18833306 chr6:118973337 C6orf204 0.44 5.64 0.3 3.67e-8 Diastolic blood pressure; CRC trans rs9858542 0.953 rs3811699 chr3:49396360 T/C cg21665057 chr3:196295764 WDR53;FBXO45 -0.64 -8.75 -0.43 1.1e-16 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs1218582 0.741 rs11264283 chr1:154869552 A/G cg03351412 chr1:154909251 PMVK 0.55 8.8 0.44 7.77e-17 Prostate cancer; CRC cis rs4713118 0.662 rs9468276 chr6:28027688 A/C cg02683197 chr6:28174875 NA 0.75 9.78 0.47 5.25e-20 Parkinson's disease; CRC cis rs11761441 0.602 rs35256056 chr7:87035 G/C cg12845006 chr7:82380 NA -0.23 -5.64 -0.3 3.63e-8 Alzheimer's disease in APOE e4- carriers; CRC cis rs4713118 0.662 rs149947 chr6:27972433 A/T cg12172441 chr6:28176163 NA 0.58 7.75 0.39 1.13e-13 Parkinson's disease; CRC cis rs4819052 0.851 rs7276591 chr21:46680156 C/T cg19498844 chr21:46707878 POFUT2;LOC642852 0.77 11.16 0.52 9.91e-25 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs9828933 0.701 rs7621544 chr3:63928681 C/A cg16258503 chr3:63850278 ATXN7;THOC7 -0.52 -5.97 -0.31 6.26e-9 Type 2 diabetes; CRC cis rs62408225 1.000 rs56106243 chr6:90975990 C/T cg06866423 chr6:90926672 BACH2 0.5 8.23 0.41 4.55e-15 Eosinophil counts;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC cis rs6088590 0.561 rs6088527 chr20:33155841 C/T cg24642439 chr20:33292090 TP53INP2 0.39 6.81 0.35 4.61e-11 Coronary artery disease; CRC cis rs11098499 0.863 rs13140391 chr4:120503437 A/G cg09307838 chr4:120376055 NA 0.69 10.17 0.49 2.66e-21 Corneal astigmatism; CRC cis rs1267303 0.537 rs59935547 chr1:47001423 A/G cg08533674 chr1:46993347 NA -0.77 -10.37 -0.5 5.43e-22 Monobrow; CRC cis rs2239547 0.522 rs2581823 chr3:53022076 C/G cg11645453 chr3:52864694 ITIH4 -0.54 -9.72 -0.47 8.19e-20 Schizophrenia; CRC cis rs637571 0.522 rs550435 chr11:65732651 G/A cg26695010 chr11:65641043 EFEMP2 -0.38 -5.76 -0.3 1.96e-8 Eosinophil percentage of white cells; CRC cis rs10883723 0.810 rs3781289 chr10:104244991 G/T cg22532475 chr10:104410764 TRIM8 -0.36 -6.5 -0.34 3.05e-10 Allergic disease (asthma, hay fever or eczema); CRC cis rs7786808 0.778 rs34212455 chr7:158224490 C/T cg17401720 chr7:158221031 PTPRN2 0.46 7.36 0.38 1.51e-12 Obesity-related traits; CRC cis rs972578 1.000 rs5759067 chr22:43372799 T/C cg01576275 chr22:43409880 NA -0.47 -7.6 -0.39 3.1e-13 Mean platelet volume; CRC cis rs1009181 0.585 rs4486004 chr6:26167710 G/T cg00631329 chr6:26305371 NA -0.42 -6.08 -0.32 3.33e-9 Childhood ear infection; CRC cis rs7605827 0.866 rs4668917 chr2:15661815 G/C cg19274914 chr2:15703543 NA 0.39 5.84 0.31 1.23e-8 Educational attainment (years of education); CRC cis rs7224737 0.957 rs6503687 chr17:40295397 G/A cg02228675 chr17:40259724 DHX58 -0.48 -6.8 -0.35 5.05e-11 Fibrinogen levels; CRC cis rs10540 1.000 rs12421457 chr11:505780 T/C cg03576123 chr11:487126 PTDSS2 -1.04 -10.79 -0.51 1.91e-23 Body mass index; CRC cis rs7493 0.755 rs17883791 chr7:94999438 G/A cg19678392 chr7:94953810 PON1 -0.52 -6.59 -0.34 1.77e-10 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs12479064 0.724 rs737094 chr2:100089078 G/A cg26064155 chr2:99771622 LIPT1;TSGA10 -0.62 -7.28 -0.37 2.5e-12 Chronic sinus infection; CRC cis rs637571 0.510 rs4930320 chr11:65576788 C/G cg26695010 chr11:65641043 EFEMP2 0.48 7.46 0.38 7.59e-13 Eosinophil percentage of white cells; CRC cis rs57221529 0.766 rs17563576 chr5:560476 A/G cg09021430 chr5:549028 NA -0.68 -8.09 -0.41 1.14e-14 Lung disease severity in cystic fibrosis; CRC cis rs7147624 0.938 rs7151148 chr14:65936665 G/C cg03016385 chr14:66212404 NA -0.99 -10.2 -0.49 2.1e-21 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs9611565 0.659 rs1810461 chr22:41927820 G/A cg17554472 chr22:41940697 POLR3H -0.55 -5.84 -0.31 1.23e-8 Vitiligo; CRC cis rs3135063 0.504 rs78139882 chr4:3287361 C/T cg15436123 chr4:3390332 RGS12 -0.35 -6.83 -0.35 4.14e-11 Blood protein levels; CRC cis rs1707322 0.721 rs4564187 chr1:46166861 G/C cg03146154 chr1:46216737 IPP 0.67 9.82 0.48 3.95e-20 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs7618915 0.547 rs8906 chr3:52739520 T/C cg18099408 chr3:52552593 STAB1 -0.44 -7.16 -0.37 5.39e-12 Bipolar disorder; CRC cis rs4722166 0.704 rs4321884 chr7:22741459 A/T cg05472934 chr7:22766657 IL6 0.45 6.85 0.35 3.61e-11 Lung cancer; CRC cis rs10504229 0.683 rs11786523 chr8:58131319 G/C cg22535103 chr8:58192502 C8orf71 -0.7 -9.34 -0.46 1.47e-18 Developmental language disorder (linguistic errors); CRC cis rs62064224 0.589 rs4523973 chr17:30809455 G/A cg09324608 chr17:30823087 MYO1D 0.34 5.98 0.31 5.72e-9 Schizophrenia; CRC cis rs10504229 0.953 rs75545548 chr8:58172816 T/C cg01721255 chr8:58191610 C8orf71 0.49 6.17 0.32 2e-9 Developmental language disorder (linguistic errors); CRC cis rs68170813 0.559 rs74745121 chr7:106958037 T/C cg02696742 chr7:106810147 HBP1 -0.59 -6.54 -0.34 2.29e-10 Coronary artery disease; CRC cis rs9787249 0.957 rs12239844 chr1:40217258 T/C cg19912559 chr1:40204330 PPIE 0.52 7.7 0.39 1.6e-13 Blood protein levels; CRC cis rs11122272 0.735 rs2437148 chr1:231513979 A/G cg06096015 chr1:231504339 EGLN1 0.4 5.95 0.31 6.7e-9 Hemoglobin concentration; CRC trans rs9291683 0.546 rs13139055 chr4:10038924 G/T cg26043149 chr18:55253948 FECH 0.51 7.63 0.39 2.52e-13 Bone mineral density; CRC cis rs3796352 0.881 rs35384050 chr3:53008769 G/T cg27565382 chr3:53032988 SFMBT1 0.65 5.68 0.3 2.94e-8 Immune reponse to smallpox (secreted IL-2); CRC cis rs1044826 0.642 rs6439860 chr3:139175797 A/G cg00490450 chr3:139108681 COPB2 0.41 6.13 0.32 2.48e-9 Obesity-related traits; CRC cis rs2880765 0.835 rs4842886 chr15:86035773 G/A cg17133734 chr15:86042851 AKAP13 0.42 6.65 0.34 1.23e-10 Coronary artery disease; CRC trans rs6561151 0.645 rs61959960 chr13:44439265 T/G cg12856521 chr11:46389249 DGKZ 0.76 10.57 0.5 1.14e-22 Crohn's disease; CRC cis rs4721295 0.502 rs2058430 chr7:2206110 A/G cg21782813 chr7:2030301 MAD1L1 0.41 6.54 0.34 2.3e-10 Schizophrenia, schizoaffective disorder or bipolar disorder; CRC cis rs4594175 0.707 rs12432912 chr14:51739395 T/C cg23942311 chr14:51606299 NA 0.47 7.03 0.36 1.21e-11 Cancer; CRC cis rs524281 0.773 rs11227448 chr11:66048491 G/A cg14036092 chr11:66035641 RAB1B -0.56 -6.1 -0.32 3e-9 Electroencephalogram traits; CRC cis rs2549003 1.000 rs2070727 chr5:131820275 C/A cg02551604 chr5:131831745 NA -0.54 -8.34 -0.42 2e-15 Asthma (sex interaction); CRC cis rs4713118 0.869 rs7776351 chr6:27726731 A/G cg21251018 chr6:28226885 NKAPL -0.41 -6.21 -0.32 1.63e-9 Parkinson's disease; CRC cis rs7923609 0.869 rs10733792 chr10:65232539 A/G cg08743896 chr10:65200160 JMJD1C -0.42 -6.05 -0.32 3.87e-9 Educational attainment;Liver enzyme levels (alkaline phosphatase); CRC cis rs7552404 0.727 rs1144336 chr1:76277421 C/A cg22875332 chr1:76189707 ACADM 0.57 7.79 0.39 8.83e-14 Blood metabolite levels;Acylcarnitine levels; CRC cis rs10504229 0.906 rs113745779 chr8:58191301 C/G cg05313129 chr8:58192883 C8orf71 -0.47 -6.99 -0.36 1.49e-11 Developmental language disorder (linguistic errors); CRC cis rs7259376 0.936 rs8108630 chr19:22535177 G/T cg02657401 chr19:22469223 NA -0.33 -7.39 -0.38 1.19e-12 Menopause (age at onset); CRC cis rs7703744 0.681 rs17145294 chr5:118701433 G/T cg19893178 chr5:118692011 TNFAIP8 0.44 5.94 0.31 7.41e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs6662572 1.000 rs6662999 chr1:46119351 C/G cg08644498 chr1:46502608 NA 0.44 6.4 0.33 5.46e-10 Blood protein levels; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg02849769 chr1:110527541 AHCYL1 0.44 6.04 0.32 4.09e-9 Anxiety disorder; CRC cis rs6089584 0.927 rs2296081 chr20:60572663 G/T cg23262073 chr20:60523788 NA -0.42 -7.08 -0.36 8.81e-12 Body mass index; CRC cis rs7772486 0.754 rs9390356 chr6:146118983 A/T cg23711669 chr6:146136114 FBXO30 -0.78 -13.54 -0.6 1.65e-33 Lobe attachment (rater-scored or self-reported); CRC trans rs4869931 0.790 rs17080108 chr6:151006643 T/C cg01367992 chr1:160766535 LY9 0.37 6.06 0.32 3.76e-9 Systolic blood pressure in sickle cell anemia; CRC cis rs977987 0.843 rs7499872 chr16:75426529 G/A cg03315344 chr16:75512273 CHST6 0.52 8.85 0.44 5.42e-17 Dupuytren's disease; CRC cis rs7072216 0.763 rs10883091 chr10:100167239 C/T cg26618903 chr10:100175079 PYROXD2 -0.53 -8.78 -0.44 9.08e-17 Metabolite levels; CRC cis rs965469 0.779 rs6051820 chr20:3365301 A/G cg25506879 chr20:3388711 C20orf194 -0.37 -5.76 -0.3 1.96e-8 IFN-related cytopenia; CRC cis rs425277 0.500 rs908744 chr1:2038893 G/A cg12639453 chr1:2035780 PRKCZ -0.39 -7.55 -0.38 4.45e-13 Height; CRC cis rs950776 0.722 rs471889 chr15:78870235 T/C cg06917634 chr15:78832804 PSMA4 -0.55 -8.22 -0.41 4.76e-15 Sudden cardiac arrest; CRC cis rs6840360 0.667 rs9994482 chr4:152391230 T/C cg09659197 chr4:152720779 NA 0.34 6.63 0.34 1.34e-10 Intelligence (multi-trait analysis); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg11851522 chr11:71791722 LRTOMT;NUMA1 0.44 5.99 0.31 5.51e-9 Response to antipsychotic treatment; CRC cis rs4713118 0.588 rs200994 chr6:27813813 A/C cg12172441 chr6:28176163 NA -0.54 -6.76 -0.35 6.28e-11 Parkinson's disease; CRC cis rs11214589 0.905 rs12805699 chr11:113241810 T/A cg14159747 chr11:113255604 NA 0.6 11.82 0.55 4.17e-27 Neuroticism; CRC cis rs7590720 0.731 rs1864253 chr2:216878008 C/G cg12620499 chr2:216877984 MREG 1.0 20.15 0.74 2.27e-59 Alcohol dependence; CRC cis rs7772486 0.686 rs9497395 chr6:146013592 A/G cg13319975 chr6:146136371 FBXO30 0.43 6.34 0.33 7.69e-10 Lobe attachment (rater-scored or self-reported); CRC cis rs6748734 1.000 rs7604393 chr2:241825034 T/G cg04034577 chr2:241836375 C2orf54 -0.41 -8.79 -0.44 8.46e-17 Urinary metabolites; CRC cis rs11250464 0.804 rs11250463 chr10:1406228 T/C cg26394196 chr10:1453818 ADARB2 -0.32 -5.84 -0.31 1.29e-8 Radiation response; CRC cis rs67311347 1.000 rs28536038 chr3:40496382 A/C cg09455208 chr3:40491958 NA 0.48 9.32 0.46 1.75e-18 Renal cell carcinoma; CRC cis rs9359856 0.623 rs7742602 chr6:90327385 A/G cg13799429 chr6:90582589 CASP8AP2 -0.66 -9.71 -0.47 9.07e-20 Bipolar disorder; CRC cis rs2732480 0.577 rs2634678 chr12:48735538 C/G cg24011408 chr12:48396354 COL2A1 0.47 6.39 0.33 5.64e-10 Hemoglobin concentration;Red blood cell count;Hematocrit; CRC cis rs60843830 1.000 rs3791221 chr2:226933 A/G cg25945732 chr2:264204 ACP1;SH3YL1 0.73 12.13 0.56 3.1e-28 Spherical equivalent (joint analysis main effects and education interaction); CRC cis rs9926296 0.712 rs2434872 chr16:89716915 C/G cg03605463 chr16:89740564 NA 0.58 8.87 0.44 4.65e-17 Vitiligo; CRC cis rs3018066 0.666 rs79026220 chr4:107037655 A/G cg01869342 chr4:106983673 TBCK 0.46 6.03 0.32 4.52e-9 Cancer; CRC cis rs887829 0.569 rs4148326 chr2:234673462 T/C cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.48 -7.55 -0.38 4.36e-13 Metabolic traits;Bilirubin levels;Cholelithiasis-related traits in sickle cell anemia;Metabolite levels;Total bilirubin levels in HIV-1 infection;Serum metabolite levels;Blood metabolite levels; CRC cis rs2204008 0.557 rs11520191 chr12:38197057 T/A cg26384229 chr12:38710491 ALG10B 0.66 8.79 0.44 8.68e-17 Bladder cancer; CRC cis rs10540 1.000 rs116876680 chr11:517473 G/T cg03934478 chr11:495069 RNH1 0.71 7.87 0.4 5.25e-14 Body mass index; CRC cis rs4713118 0.869 rs9461401 chr6:27703291 G/A cg02683197 chr6:28174875 NA 0.63 8.62 0.43 2.81e-16 Parkinson's disease; CRC cis rs12477438 1.000 rs995617 chr2:99857904 G/T cg26064155 chr2:99771622 LIPT1;TSGA10 0.72 8.75 0.43 1.16e-16 Chronic sinus infection; CRC cis rs9549367 0.789 rs12869947 chr13:113896156 A/G cg00898013 chr13:113819073 PROZ -0.47 -6.52 -0.34 2.6e-10 Platelet distribution width; CRC cis rs763014 0.966 rs4984903 chr16:680695 A/G cg04497992 chr16:616212 NHLRC4 0.41 6.45 0.33 4.07e-10 Height; CRC cis rs6545883 0.929 rs2593627 chr2:61618574 T/C cg15711740 chr2:61764176 XPO1 0.43 5.81 0.31 1.47e-8 Tuberculosis; CRC cis rs2070488 0.775 rs6599207 chr3:38554901 T/C cg01465620 chr3:38496096 LOC100128640;ACVR2B -0.75 -12.57 -0.57 7.21e-30 Electrocardiographic conduction measures; CRC cis rs282587 0.502 rs382758 chr13:113400169 C/T cg04656015 chr13:113407548 ATP11A 0.61 7.68 0.39 1.83e-13 Glycated hemoglobin levels; CRC cis rs2737618 0.722 rs2258675 chr1:200091548 G/C cg21825944 chr1:200113062 NR5A2 -0.52 -7.36 -0.38 1.46e-12 Uric acid levels; CRC cis rs11583043 0.918 rs6577216 chr1:101409972 C/A cg00063077 chr1:101360652 SLC30A7;EXTL2 0.49 6.87 0.35 3.28e-11 Ulcerative colitis;Inflammatory bowel disease; CRC cis rs2625529 0.652 rs3759820 chr15:72300031 A/C cg16672083 chr15:72433130 SENP8 0.46 7.05 0.36 1.09e-11 Red blood cell count; CRC cis rs6952808 1.000 rs12540579 chr7:1882227 C/A cg04267008 chr7:1944627 MAD1L1 -0.72 -10.54 -0.5 1.37e-22 Bipolar disorder and schizophrenia; CRC cis rs2404618 0.534 rs2214861 chr8:1490604 A/G cg02903104 chr8:1507517 DLGAP2 0.48 8.88 0.44 4.49e-17 Lung cancer; CRC cis rs992157 0.835 rs12987180 chr2:219144089 G/A cg04880052 chr2:219191631 PNKD -0.44 -6.98 -0.36 1.66e-11 Colorectal cancer; CRC cis rs13191362 0.935 rs34709632 chr6:163048380 A/G cg14584255 chr6:163149320 PACRG;PARK2 0.43 6.05 0.32 3.87e-9 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs7666738 0.649 rs28865589 chr4:98954279 C/A cg17366294 chr4:99064904 C4orf37 0.43 7.31 0.37 1.98e-12 Colonoscopy-negative controls vs population controls; CRC cis rs11190604 1.000 rs10883502 chr10:102238343 T/G cg07080220 chr10:102295463 HIF1AN 0.48 5.79 0.3 1.61e-8 Palmitoleic acid (16:1n-7) levels; CRC cis rs2836974 0.899 rs34433511 chr21:40618883 A/C cg06238570 chr21:40685208 BRWD1 0.78 10.78 0.51 2.06e-23 Cognitive function; CRC cis rs9487051 0.676 rs7753705 chr6:109593302 A/C cg01475377 chr6:109611718 NA -0.37 -6.58 -0.34 1.85e-10 Reticulocyte fraction of red cells; CRC cis rs8177179 0.967 rs6439434 chr3:133450371 T/G cg17775713 chr3:133465469 TF 0.37 6.76 0.35 6.35e-11 Iron status biomarkers (transferrin levels); CRC cis rs9733 0.744 rs12125650 chr1:150760174 A/G cg17724175 chr1:150552817 MCL1 -0.38 -5.77 -0.3 1.79e-8 Tonsillectomy; CRC cis rs172166 0.694 rs1770131 chr6:28086413 C/T cg03623178 chr6:28175578 NA 0.79 11.41 0.53 1.22e-25 Cardiac Troponin-T levels; CRC cis rs910316 0.737 rs175084 chr14:75519175 C/T cg08847533 chr14:75593920 NEK9 -0.86 -15.06 -0.64 2.43e-39 Height; CRC cis rs9611565 0.802 rs2234058 chr22:41777883 G/A cg06481639 chr22:41940642 POLR3H -0.5 -5.66 -0.3 3.31e-8 Vitiligo; CRC cis rs10078 0.515 rs2672739 chr5:443447 A/C cg08916839 chr5:415575 AHRR 0.74 7.68 0.39 1.83e-13 Fat distribution (HIV); CRC cis rs13191362 1.000 rs36113695 chr6:163004733 T/A cg23758597 chr6:163146217 PARK2 -0.55 -6.13 -0.32 2.54e-9 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs2404602 0.647 rs12440511 chr15:76993135 A/G cg23625390 chr15:77176239 SCAPER -0.86 -13.91 -0.61 6.28e-35 Blood metabolite levels; CRC cis rs8180040 0.966 rs59586735 chr3:47518325 C/T cg27129171 chr3:47204927 SETD2 -0.6 -9.27 -0.45 2.59e-18 Colorectal cancer; CRC cis rs57221529 0.709 rs72703090 chr5:598314 C/T cg17948913 chr5:572064 NA 0.5 5.79 0.3 1.61e-8 Lung disease severity in cystic fibrosis; CRC cis rs6546324 0.625 rs2861645 chr2:67800338 T/A cg15745817 chr2:67799979 NA -0.57 -9.8 -0.48 4.45e-20 Endometriosis; CRC cis rs8062405 1.000 rs7187776 chr16:28857645 A/G cg16576597 chr16:28551801 NUPR1 0.41 5.97 0.31 6.26e-9 Cognitive ability (multi-trait analysis);Cognitive ability; CRC cis rs10751667 0.666 rs7483273 chr11:951127 T/C cg01483505 chr11:975446 AP2A2 0.45 7.38 0.38 1.34e-12 Alzheimer's disease (late onset); CRC cis rs8141529 0.764 rs5752807 chr22:29223169 A/G cg02153584 chr22:29168773 CCDC117 0.52 7.75 0.39 1.17e-13 Lymphocyte counts; CRC cis rs11608355 0.521 rs6606707 chr12:109830241 T/G cg19025524 chr12:109796872 NA -0.56 -9.0 -0.44 1.78e-17 Neuroticism; CRC cis rs8062405 1.000 rs4788101 chr16:28867804 C/T cg16576597 chr16:28551801 NUPR1 0.48 6.83 0.35 4.14e-11 Cognitive ability (multi-trait analysis);Cognitive ability; CRC cis rs11098499 0.913 rs10006304 chr4:120124305 A/G cg24375607 chr4:120327624 NA 0.48 7.41 0.38 1.07e-12 Corneal astigmatism; CRC cis rs1223397 0.938 rs13205692 chr6:13291560 C/T cg07912922 chr6:13274314 PHACTR1 0.54 6.46 0.34 3.68e-10 Blood pressure; CRC cis rs853679 0.513 rs9468296 chr6:28113730 A/G cg02683197 chr6:28174875 NA 0.87 10.73 0.51 3.25e-23 Depression; CRC cis rs853679 0.517 rs9468292 chr6:28095355 G/A cg15786705 chr6:28176104 NA 0.77 9.75 0.47 6.92e-20 Depression; CRC cis rs34779708 0.931 rs2384289 chr10:35343525 G/A cg03585969 chr10:35415529 CREM 0.58 7.82 0.4 7.34e-14 Inflammatory bowel disease;Crohn's disease; CRC cis rs7618915 0.571 rs7623199 chr3:52605974 C/T cg08222913 chr3:52553049 STAB1 -0.34 -6.27 -0.33 1.14e-9 Bipolar disorder; CRC cis rs10416265 0.527 rs11084699 chr19:33538393 A/T cg27124370 chr19:33622961 WDR88 0.49 7.51 0.38 5.7e-13 Bone properties (heel); CRC cis rs644799 1.000 rs516551 chr11:95588626 C/T cg25622487 chr11:95524042 FAM76B;CEP57 0.76 11.8 0.55 5.06e-27 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs208520 0.874 rs208518 chr6:66948501 C/G cg07460842 chr6:66804631 NA 0.92 11.89 0.55 2.27e-27 Exhaled nitric oxide output; CRC cis rs7659604 0.537 rs6823818 chr4:122731699 G/C cg20573242 chr4:122745356 CCNA2 0.57 8.32 0.42 2.37e-15 Type 2 diabetes; CRC cis rs6502050 0.835 rs67106357 chr17:80116826 T/G cg13198984 chr17:80129470 CCDC57 0.46 8.18 0.41 6.3e-15 Life satisfaction; CRC cis rs992157 0.798 rs10193383 chr2:219157692 C/T cg13835894 chr2:219148914 PNKD;TMBIM1 0.33 6.31 0.33 8.82e-10 Colorectal cancer; CRC cis rs7666738 0.925 rs34423396 chr4:99049031 T/A cg03676636 chr4:99064102 C4orf37 0.22 6.26 0.33 1.17e-9 Colonoscopy-negative controls vs population controls; CRC trans rs17685 0.753 rs13240967 chr7:75658197 C/T cg19862616 chr7:65841803 NCRNA00174 -0.96 -17.56 -0.7 3.66e-49 Coffee consumption;Coffee consumption (cups per day); CRC cis rs6860806 0.631 rs4705931 chr5:131588345 T/C cg12564285 chr5:131593104 PDLIM4 0.5 9.69 0.47 1.1e-19 Breast cancer; CRC cis rs9287719 0.967 rs6432117 chr2:10749359 G/C cg00105475 chr2:10696890 NA 0.45 7.17 0.37 4.87e-12 Prostate cancer; CRC cis rs853679 0.882 rs9393908 chr6:28190830 T/A cg15845792 chr6:28175446 NA 0.8 6.39 0.33 5.67e-10 Depression; CRC cis rs7937682 0.883 rs486038 chr11:111465963 A/C cg09085632 chr11:111637200 PPP2R1B -0.94 -17.74 -0.7 7.01e-50 Primary sclerosing cholangitis; CRC cis rs911555 0.755 rs975892 chr14:103883349 A/T cg12935359 chr14:103987150 CKB -0.56 -9.06 -0.45 1.17e-17 Intelligence (multi-trait analysis); CRC cis rs4638749 1.000 rs2198463 chr2:108875093 T/A cg25838818 chr2:108905173 SULT1C2 -0.38 -6.06 -0.32 3.82e-9 Blood pressure; CRC cis rs79149102 0.579 rs61166993 chr15:75306644 C/A cg09165964 chr15:75287851 SCAMP5 -0.59 -6.38 -0.33 6.07e-10 Lung cancer; CRC cis rs10504229 0.683 rs73603877 chr8:58108428 C/T cg24829409 chr8:58192753 C8orf71 -0.56 -7.95 -0.4 3.02e-14 Developmental language disorder (linguistic errors); CRC cis rs9649213 0.593 rs3801254 chr7:98010811 G/A cg00277769 chr7:97922759 BAIAP2L1 -0.58 -9.91 -0.48 1.96e-20 Prostate cancer (SNP x SNP interaction); CRC cis rs9469578 1.000 rs9469580 chr6:33715837 A/G cg18708504 chr6:33715942 IP6K3 -0.65 -7.64 -0.39 2.34e-13 Phosphorus levels; CRC cis rs2180341 0.960 rs1543432 chr6:127698018 T/C cg27446573 chr6:127587934 RNF146 0.98 13.85 0.61 1.08e-34 Breast cancer; CRC trans rs7395662 0.929 rs12366252 chr11:48542318 G/A cg21153622 chr11:89784906 NA -0.48 -7.61 -0.39 2.96e-13 HDL cholesterol; CRC cis rs1843834 1.000 rs1565072 chr2:225545245 C/T cg22455342 chr2:225449267 CUL3 -0.48 -6.66 -0.34 1.14e-10 IgE levels in asthmatics (D.p. specific); CRC cis rs1153858 1.000 rs66528868 chr15:45668547 A/C cg21132104 chr15:45694354 SPATA5L1 0.57 8.29 0.42 2.85e-15 Homoarginine levels; CRC cis rs13191362 0.507 rs13211655 chr6:163177542 C/G cg06582575 chr6:163149167 PACRG;PARK2 0.53 8.18 0.41 6.35e-15 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs12995491 0.731 rs17435439 chr2:88511391 A/G cg18490616 chr2:88469792 THNSL2 -0.39 -5.7 -0.3 2.67e-8 Response to metformin (IC50); CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg04585517 chr2:37899444 CDC42EP3 -0.41 -6.02 -0.31 4.67e-9 Myopia (pathological); CRC cis rs6088590 1.000 rs12626122 chr20:33425800 A/G cg24642439 chr20:33292090 TP53INP2 0.58 9.56 0.47 2.81e-19 Coronary artery disease; CRC cis rs17253792 0.822 rs7145064 chr14:56088860 C/T cg24579896 chr14:56047964 C14orf33;KTN1 0.71 5.69 0.3 2.84e-8 Putamen volume; CRC cis rs7312774 0.618 rs4964501 chr12:107330079 C/T cg16260113 chr12:107380972 MTERFD3 -0.75 -7.57 -0.39 3.76e-13 Severe influenza A (H1N1) infection; CRC trans rs2727020 0.675 rs1684258 chr11:49340020 G/A cg03929089 chr4:120376271 NA 0.66 8.27 0.41 3.38e-15 Coronary artery disease; CRC cis rs9807989 0.811 rs11688573 chr2:102969971 C/A cg03938978 chr2:103052716 IL18RAP 0.37 5.97 0.31 6.2e-9 Asthma; CRC cis rs3617 0.573 rs2336667 chr3:52916363 C/T cg07507251 chr3:52567010 NT5DC2 -0.37 -5.73 -0.3 2.29e-8 Red blood cell count;Autism spectrum disorder or schizophrenia; CRC cis rs4664293 0.609 rs10167143 chr2:160463396 T/A cg08347373 chr2:160653686 CD302 -0.39 -6.49 -0.34 3.11e-10 Monocyte percentage of white cells; CRC cis rs8014204 0.935 rs1799900 chr14:75367740 G/A cg03030879 chr14:75389066 RPS6KL1 0.55 9.13 0.45 6.87e-18 Caffeine consumption; CRC cis rs883565 0.569 rs1274970 chr3:39163252 A/G cg01426195 chr3:39028469 NA 0.41 6.76 0.35 6.21e-11 Handedness; CRC cis rs311392 0.966 rs425548 chr8:55087468 C/T cg20636351 chr8:55087400 NA -0.33 -5.9 -0.31 9.15e-9 Pelvic organ prolapse (moderate/severe); CRC cis rs28386778 0.897 rs2727326 chr17:61923016 G/A cg23090583 chr17:61904693 PSMC5;FTSJ3 1.03 20.18 0.74 1.67e-59 Prudent dietary pattern; CRC cis rs769267 0.930 rs751856 chr19:19602945 A/G cg01262667 chr19:19385393 TM6SF2 0.36 5.95 0.31 6.9e-9 Tonsillectomy; CRC cis rs11645898 0.688 rs437638 chr16:72095452 C/T cg14768367 chr16:72042858 DHODH -0.71 -7.24 -0.37 3.25e-12 Blood protein levels; CRC cis rs6912958 0.781 rs9444512 chr6:88223397 G/A cg12350822 chr6:88032061 C6orf162;GJB7 -0.36 -6.73 -0.35 7.4e-11 Monocyte percentage of white cells; CRC cis rs10504229 0.683 rs11786043 chr8:58133174 T/C cg04204079 chr8:58130323 NA -0.45 -5.78 -0.3 1.71e-8 Developmental language disorder (linguistic errors); CRC cis rs3015497 0.789 rs2934688 chr14:51112360 G/A cg09863266 chr14:51125203 SAV1 -0.32 -6.13 -0.32 2.51e-9 Mean platelet volume; CRC cis rs2425143 1.000 rs8116836 chr20:34453362 T/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.5 -5.95 -0.31 6.78e-9 Blood protein levels; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg25486472 chr5:141348514 RNF14 0.44 6.26 0.33 1.18e-9 Response to antipsychotic treatment; CRC cis rs6723226 0.708 rs2754513 chr2:32782763 G/A cg02381751 chr2:32503542 YIPF4 0.53 7.66 0.39 2.09e-13 Intelligence (multi-trait analysis); CRC cis rs769267 0.930 rs7254927 chr19:19404786 C/G cg02546618 chr19:19431379 KIAA0892;SF4 0.46 6.35 0.33 7.02e-10 Tonsillectomy; CRC cis rs7534824 0.507 rs61780294 chr1:101398011 C/T cg16556008 chr1:101360663 SLC30A7;EXTL2 0.58 5.92 0.31 8.2e-9 Refractive astigmatism; CRC cis rs3087591 0.960 rs4263003 chr17:29438508 G/T cg24425628 chr17:29625626 OMG;NF1 0.78 14.12 0.61 9.75e-36 Hip circumference; CRC cis rs951366 0.559 rs823101 chr1:205667006 T/C cg07157834 chr1:205819609 PM20D1 0.73 10.36 0.5 5.76e-22 Menarche (age at onset); CRC cis rs1799949 1.000 rs2070834 chr17:41242285 T/G cg19454999 chr17:41278357 BRCA1;NBR2 0.56 8.66 0.43 2.13e-16 Menopause (age at onset); CRC cis rs9611565 0.659 rs4822037 chr22:41945113 G/T cg06634786 chr22:41940651 POLR3H -0.7 -8.15 -0.41 7.66e-15 Vitiligo; CRC trans rs10842750 1.000 rs10842750 chr12:26690565 G/T cg15365588 chr7:7681016 RPA3 0.5 6.12 0.32 2.63e-9 Kashin-Beck disease; CRC cis rs1577917 0.771 rs4441928 chr6:86241894 T/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A 0.64 8.61 0.43 3.04e-16 Response to antipsychotic treatment; CRC cis rs2836974 0.897 rs2836973 chr21:40654928 A/G cg11644478 chr21:40555479 PSMG1 0.83 13.21 0.59 2.89e-32 Cognitive function; CRC cis rs59104589 0.617 rs60614486 chr2:242274998 C/G cg19488206 chr2:242435732 STK25 0.46 6.42 0.33 4.67e-10 Fibrinogen levels; CRC cis rs755249 0.567 rs61779275 chr1:39820310 C/T cg18385671 chr1:39797026 MACF1 -0.4 -5.71 -0.3 2.59e-8 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs736408 0.562 rs13071584 chr3:52804487 T/C cg15147215 chr3:52552868 STAB1 -0.62 -10.56 -0.5 1.25e-22 Bipolar disorder; CRC cis rs3106136 0.967 rs2632399 chr4:95153741 G/T cg11021082 chr4:95130006 SMARCAD1 -0.46 -7.16 -0.37 5.15e-12 Capecitabine sensitivity; CRC cis rs2415984 0.579 rs2254846 chr14:46973394 G/A cg14871534 chr14:47121158 RPL10L 0.39 5.92 0.31 8.03e-9 Number of children ever born; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg10452531 chr12:6493278 LTBR 0.38 6.71 0.35 8.48e-11 Liver disease severity in Alagille syndrome; CRC cis rs9322193 0.886 rs9718079 chr6:149967083 T/C cg07701084 chr6:150067640 NUP43 0.57 8.25 0.41 3.86e-15 Lung cancer; CRC cis rs950027 0.620 rs1049518 chr15:45653367 G/A cg10760299 chr15:45669010 GATM 0.37 5.78 0.3 1.73e-8 Response to fenofibrate (adiponectin levels); CRC cis rs7713065 0.531 rs2522051 chr5:131797578 C/T cg20512303 chr5:131592959 PDLIM4 0.31 5.89 0.31 9.49e-9 Lung function (FEV1/FVC); CRC cis rs2180341 0.814 rs6940933 chr6:127732740 C/G cg24812749 chr6:127587940 RNF146 0.67 9.0 0.44 1.88e-17 Breast cancer; CRC cis rs1538970 0.816 rs34673142 chr1:45985561 G/A cg05343316 chr1:45956843 TESK2 0.75 10.01 0.48 8.82e-21 Platelet count; CRC cis rs2153535 0.580 rs7745043 chr6:8513507 T/C cg21535247 chr6:8435926 SLC35B3 0.48 7.31 0.37 2.09e-12 Motion sickness; CRC cis rs9914988 0.943 rs66588554 chr17:27141110 A/G cg16670446 chr17:27188758 MIR451;MIR144 0.53 8.44 0.42 1.04e-15 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs10504229 0.683 rs67048677 chr8:58140023 C/G cg24829409 chr8:58192753 C8orf71 -0.55 -8.03 -0.4 1.71e-14 Developmental language disorder (linguistic errors); CRC cis rs7517126 1.000 rs13375150 chr1:196841839 C/T cg13682187 chr1:196946512 CFHR5 -0.37 -5.97 -0.31 6.03e-9 Blood protein levels; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg14575559 chr19:18111766 ARRDC2 0.45 6.29 0.33 1.03e-9 Anxiety disorder; CRC cis rs926938 0.520 rs6660624 chr1:115272163 G/A cg12756093 chr1:115239321 AMPD1 -0.65 -8.85 -0.44 5.59e-17 Autism; CRC cis rs8141529 0.702 rs469992 chr22:29314899 T/C cg02153584 chr22:29168773 CCDC117 -0.47 -6.86 -0.35 3.43e-11 Lymphocyte counts; CRC cis rs13118159 0.872 rs4974605 chr4:1346389 C/G cg15763984 chr4:1342303 KIAA1530 0.35 5.95 0.31 7.01e-9 Longevity; CRC cis rs4713118 0.824 rs2092075 chr6:27749330 G/C cg03623178 chr6:28175578 NA 0.7 9.33 0.46 1.61e-18 Parkinson's disease; CRC cis rs9611565 0.694 rs202622 chr22:41825342 T/G cg03806693 chr22:41940476 POLR3H 1.12 13.67 0.6 5.31e-34 Vitiligo; CRC trans rs60843830 0.964 rs62114538 chr2:256116 G/T cg11347411 chr7:150020925 ACTR3C;LRRC61 0.54 8.35 0.42 1.97e-15 Spherical equivalent (joint analysis main effects and education interaction); CRC cis rs12745968 0.623 rs1886684 chr1:92975938 T/C cg17283838 chr1:93427260 FAM69A -0.47 -6.3 -0.33 9.41e-10 Bipolar disorder and schizophrenia; CRC cis rs9322193 0.884 rs9689702 chr6:150061856 G/A cg00933542 chr6:150070202 PCMT1 0.32 6.57 0.34 1.94e-10 Lung cancer; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg24838029 chr1:43833615 ELOVL1 0.36 5.97 0.31 6.14e-9 Liver disease severity in Alagille syndrome; CRC cis rs2836974 0.568 rs442972 chr21:40534757 C/T cg17971929 chr21:40555470 PSMG1 -0.73 -11.58 -0.54 3.03e-26 Cognitive function; CRC cis rs2153535 0.542 rs6905925 chr6:8440030 C/T cg21535247 chr6:8435926 SLC35B3 0.48 7.24 0.37 3.19e-12 Motion sickness; CRC cis rs711830 1.000 rs6433571 chr2:177039578 G/T cg13092806 chr2:177043255 NA 0.74 9.21 0.45 3.97e-18 Serous invasive ovarian cancer;Epithelial ovarian cancer;Invasive epithelial ovarian cancer;Mucinous ovarian carcinoma;Low-grade serous and serous borderline ovarian cancer;Serous borderline ovarian cancer;High-grade serous ovarian cancer; CRC cis rs477895 0.713 rs1059440 chr11:63991801 C/T cg19465662 chr11:63993652 NUDT22;TRPT1 -0.77 -9.67 -0.47 1.27e-19 Mean platelet volume; CRC cis rs17539620 0.624 rs74551216 chr6:154840524 T/C cg20019720 chr6:154832845 CNKSR3 0.51 7.9 0.4 4.18e-14 Lipoprotein (a) levels; CRC cis rs72781680 0.756 rs2551337 chr2:24006886 C/T cg08917208 chr2:24149416 ATAD2B 0.61 6.99 0.36 1.5e-11 Lymphocyte counts; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg27238079 chr10:33247273 ITGB1 0.36 6.2 0.32 1.66e-9 Liver disease severity in Alagille syndrome; CRC cis rs801193 1.000 rs2659909 chr7:66160279 G/A cg18876405 chr7:65276391 NA 0.62 11.23 0.53 5.31e-25 Aortic root size; CRC cis rs4665809 0.549 rs7577896 chr2:26524493 C/T cg26119090 chr2:26468346 HADHA;HADHB 0.98 12.07 0.55 5.12e-28 Gut microbiome composition (summer); CRC cis rs6502050 0.731 rs4789730 chr17:80145983 T/A cg19223190 chr17:80058835 NA 0.4 6.42 0.33 4.82e-10 Life satisfaction; CRC cis rs17092148 0.887 rs2295443 chr20:33173827 T/C cg08999081 chr20:33150536 PIGU 0.49 6.3 0.33 9.31e-10 Neuroticism; CRC cis rs67311347 1.000 rs7641495 chr3:40494690 T/C cg09455208 chr3:40491958 NA -0.43 -8.69 -0.43 1.74e-16 Renal cell carcinoma; CRC cis rs10870270 0.956 rs10781555 chr10:133745720 G/A cg08754478 chr10:133766260 PPP2R2D -0.68 -9.75 -0.47 6.55e-20 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; CRC cis rs1865760 0.865 rs9467648 chr6:25957933 T/A cg16482183 chr6:26056742 HIST1H1C 0.54 7.99 0.4 2.27e-14 Height; CRC cis rs763014 0.966 rs12935215 chr16:670605 T/C cg03804128 chr16:635623 NA 0.3 7.06 0.36 9.96e-12 Height; CRC cis rs8180040 0.620 rs9875235 chr3:47083621 G/A cg10298567 chr3:47292165 KIF9 -0.38 -5.82 -0.31 1.39e-8 Colorectal cancer; CRC cis rs873946 0.517 rs2803990 chr10:134560340 A/G cg18305652 chr10:134549665 INPP5A 0.42 6.14 0.32 2.32e-9 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CRC cis rs9322193 0.926 rs2342860 chr6:150098777 T/C cg07701084 chr6:150067640 NUP43 0.47 6.61 0.34 1.51e-10 Lung cancer; CRC cis rs372883 0.580 rs2254038 chr21:30745722 C/T cg08807101 chr21:30365312 RNF160 0.5 7.17 0.37 5.08e-12 Pancreatic cancer; CRC trans rs2303319 0.504 rs12470830 chr2:162429996 C/T cg20397358 chr22:38597902 MAFF -0.73 -6.01 -0.31 4.9e-9 Cognitive function; CRC cis rs478304 0.934 rs506853 chr11:65521247 C/T cg08755490 chr11:65554678 OVOL1 0.42 6.15 0.32 2.24e-9 Acne (severe); CRC cis rs4862750 0.872 rs4862748 chr4:187877388 C/T cg10295955 chr4:187884368 NA 1.0 20.24 0.74 9.46e-60 Lobe attachment (rater-scored or self-reported); CRC cis rs6951245 0.935 rs76525951 chr7:1096013 C/T cg22907277 chr7:1156413 C7orf50 0.72 7.6 0.39 3.1400000000000003e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs4834770 1.000 rs878374 chr4:120237564 A/G cg24375607 chr4:120327624 NA 0.34 5.63 0.3 3.94e-8 Blood protein levels; CRC cis rs6963495 0.818 rs56251768 chr7:105165591 A/G cg13798780 chr7:105162888 PUS7 0.69 8.2 0.41 5.36e-15 Bipolar disorder (body mass index interaction); CRC cis rs10746514 0.833 rs1888601 chr1:232266922 C/T cg09506761 chr1:232265262 NA -0.46 -6.72 -0.35 8.24e-11 Response to statin therapy; CRC cis rs8064299 0.584 rs2384957 chr17:72784630 A/G cg25054828 chr17:72772726 NAT9;TMEM104 0.87 14.5 0.62 3.51e-37 Monocyte count; CRC cis rs6860806 0.507 rs582490 chr5:131710095 G/A cg18758796 chr5:131593413 PDLIM4 -0.4 -6.46 -0.34 3.78e-10 Breast cancer; CRC cis rs55823223 0.503 rs55699990 chr17:73859186 A/G cg10935138 chr17:73851978 WBP2 0.56 6.98 0.36 1.59e-11 Psoriasis; CRC cis rs7103648 0.838 rs11039244 chr11:47466442 G/A cg20307385 chr11:47447363 PSMC3 0.93 14.33 0.62 1.57e-36 Diastolic blood pressure;Systolic blood pressure; CRC cis rs910316 0.935 rs175422 chr14:75627319 T/A cg08847533 chr14:75593920 NEK9 -0.93 -16.96 -0.68 8.53e-47 Height; CRC cis rs11628318 0.525 rs10129838 chr14:103154317 T/C cg08075719 chr14:103021372 NA 0.56 6.65 0.34 1.24e-10 Platelet count; CRC cis rs7246657 0.943 rs1015848 chr19:37945274 A/C cg23950597 chr19:37808831 NA -0.54 -6.46 -0.34 3.68e-10 Coronary artery calcification; CRC cis rs35883536 0.669 rs1932352 chr1:101161251 G/A cg06223162 chr1:101003688 GPR88 -0.35 -5.9 -0.31 9.16e-9 Monocyte count; CRC cis rs10504229 0.683 rs56208052 chr8:58130207 A/T cg24829409 chr8:58192753 C8orf71 -0.55 -8.03 -0.4 1.71e-14 Developmental language disorder (linguistic errors); CRC trans rs1852612 0.932 rs1852614 chr7:45404785 C/T cg16479323 chr14:93406498 ITPK1 -0.43 -5.97 -0.31 6.02e-9 QRS duration in Tripanosoma cruzi seropositivity; CRC cis rs7937682 0.847 rs11213948 chr11:111464401 G/A cg19812747 chr11:111475976 SIK2 -0.57 -9.72 -0.47 8.51e-20 Primary sclerosing cholangitis; CRC trans rs7615952 0.546 rs16836896 chr3:125311262 A/T cg21747405 chr11:67723411 NA -0.5 -6.24 -0.33 1.31e-9 Blood pressure (smoking interaction); CRC cis rs12594515 1.000 rs11070464 chr15:45984776 C/A cg22117107 chr15:45993392 NA -0.44 -8.91 -0.44 3.43e-17 Waist circumference;Weight; CRC trans rs9858542 1.000 rs11709525 chr3:49690496 C/T cg21665057 chr3:196295764 WDR53;FBXO45 -0.66 -8.5 -0.42 6.82e-16 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs9787249 0.957 rs41267029 chr1:40214367 A/G cg24920358 chr1:40204285 PPIE 0.57 8.54 0.43 5.12e-16 Blood protein levels; CRC cis rs2742540 0.503 rs982273 chr11:8906862 T/G cg14711859 chr11:8959438 ASCL3 0.57 10.21 0.49 1.91e-21 Hematocrit; CRC trans rs7618501 1.000 rs7374183 chr3:49785133 G/A cg21665057 chr3:196295764 WDR53;FBXO45 -0.87 -16.04 -0.66 3.41e-43 Intelligence (multi-trait analysis); CRC cis rs2502731 0.561 rs3003606 chr9:130982416 C/T cg09976142 chr9:130955436 CIZ1 0.41 6.81 0.35 4.65e-11 Attention deficit hyperactivity disorder; CRC cis rs6088580 0.634 rs6059851 chr20:33047945 G/A cg08999081 chr20:33150536 PIGU 0.61 11.42 0.53 1.13e-25 Glomerular filtration rate (creatinine); CRC cis rs9462027 0.628 rs9469917 chr6:34831369 G/A cg07306190 chr6:34760872 UHRF1BP1 -0.35 -6.11 -0.32 2.79e-9 Systemic lupus erythematosus; CRC cis rs9992667 1.000 rs68191221 chr4:38677062 A/G cg19726192 chr4:38663646 FLJ13197 -0.71 -9.0 -0.44 1.9e-17 Eosinophil percentage of granulocytes; CRC cis rs10751667 0.600 rs1128419 chr11:1010750 G/A ch.11.42038R chr11:967971 AP2A2 0.57 8.92 0.44 3.37e-17 Alzheimer's disease (late onset); CRC cis rs6952808 0.501 rs4721429 chr7:2171704 T/C cg04267008 chr7:1944627 MAD1L1 -0.55 -7.43 -0.38 9.24e-13 Bipolar disorder and schizophrenia; CRC cis rs3789045 0.819 rs16854023 chr1:204551830 A/G cg17419461 chr1:204415978 PIK3C2B -0.56 -7.94 -0.4 3.18e-14 Educational attainment (college completion); CRC cis rs8005677 1.000 rs1043209 chr14:23373986 A/G cg25600027 chr14:23388339 RBM23 0.5 7.93 0.4 3.55e-14 Cognitive ability (multi-trait analysis); CRC cis rs7178572 0.568 rs12907847 chr15:77493174 C/T cg22256960 chr15:77711686 NA -0.67 -9.56 -0.47 2.93e-19 Type 2 diabetes; CRC cis rs9916302 0.752 rs11078895 chr17:37401051 A/G cg00129232 chr17:37814104 STARD3 -0.51 -6.43 -0.33 4.45e-10 Glomerular filtration rate (creatinine); CRC cis rs9372498 0.536 rs72952761 chr6:118866758 A/C cg10217327 chr6:118973057 C6orf204 0.51 5.86 0.31 1.12e-8 Diastolic blood pressure; CRC cis rs4713118 0.568 rs9468213 chr6:27706180 G/A cg26587870 chr6:27730563 NA -0.36 -5.73 -0.3 2.22e-8 Parkinson's disease; CRC cis rs300703 0.719 rs423314 chr2:195372 A/G cg21211680 chr2:198530 NA 0.93 12.19 0.56 1.88e-28 Blood protein levels; CRC cis rs6558174 0.863 rs17746902 chr8:22491980 A/C cg03733263 chr8:22462867 KIAA1967 -0.5 -7.21 -0.37 3.84e-12 Breast cancer; CRC cis rs644799 1.000 rs505220 chr11:95563228 T/G cg25478527 chr11:95522999 CEP57;FAM76B 0.52 7.86 0.4 5.6e-14 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs6061231 0.724 rs1570027 chr20:60968596 A/G cg24112000 chr20:60950667 NA -0.59 -9.0 -0.44 1.82e-17 Colorectal cancer; CRC cis rs17253792 0.731 rs8008528 chr14:56062052 C/T cg01858014 chr14:56050164 KTN1 -0.85 -6.72 -0.35 7.81e-11 Putamen volume; CRC cis rs1005277 0.579 rs2505197 chr10:38393310 T/C cg25427524 chr10:38739819 LOC399744 -0.77 -13.64 -0.6 6.85e-34 Extrinsic epigenetic age acceleration; CRC cis rs1008375 0.872 rs6831115 chr4:17640463 A/G cg02297831 chr4:17616191 MED28 0.46 6.15 0.32 2.19e-9 Parasitemia in Tripanosoma cruzi seropositivity; CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg06766273 chr11:62521983 ZBTB3 -0.53 -6.39 -0.33 5.54e-10 Diisocyanate-induced asthma; CRC cis rs2066819 1.000 rs80317430 chr12:56727705 G/A cg26714650 chr12:56694279 CS -1.41 -11.53 -0.54 4.75e-26 Psoriasis vulgaris; CRC cis rs13256369 1.000 rs13266699 chr8:8570313 A/T cg17143192 chr8:8559678 CLDN23 -0.47 -6.09 -0.32 3.07e-9 Obesity-related traits; CRC cis rs9443645 0.901 rs4706079 chr6:79615208 G/A cg11833968 chr6:79620685 NA -0.37 -6.4 -0.33 5.3e-10 Intelligence (multi-trait analysis); CRC cis rs11758351 0.925 rs78932312 chr6:26194869 A/G cg22723502 chr6:26240528 HIST1H4F -0.38 -5.83 -0.31 1.35e-8 Gout;Renal underexcretion gout; CRC cis rs10486722 0.607 rs6463037 chr7:41760000 A/G cg22138096 chr7:41772439 LOC285954 0.55 7.45 0.38 8.27e-13 Pit-and-Fissure caries; CRC cis rs1707322 0.721 rs10430124 chr1:46221617 C/T cg06784218 chr1:46089804 CCDC17 0.66 11.96 0.55 1.3e-27 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs4780401 0.609 rs4781141 chr16:11808769 A/C cg01061890 chr16:11836724 TXNDC11 -0.62 -9.12 -0.45 7.41e-18 Rheumatoid arthritis; CRC cis rs6933660 0.800 rs6930557 chr6:151755806 G/A cg10883421 chr6:151773342 RMND1;C6orf211 0.74 12.79 0.58 1.1e-30 Menarche (age at onset); CRC cis rs501120 0.564 rs61855758 chr10:44684854 T/C cg09554077 chr10:44749378 NA 0.55 7.67 0.39 1.95e-13 Coronary artery disease;Coronary heart disease; CRC cis rs6912958 0.712 rs6908386 chr6:88354746 T/C cg12350822 chr6:88032061 C6orf162;GJB7 -0.32 -5.98 -0.31 5.68e-9 Monocyte percentage of white cells; CRC cis rs826838 0.967 rs826855 chr12:39114888 T/C cg13010199 chr12:38710504 ALG10B -0.39 -5.68 -0.3 2.94e-8 Heart rate; CRC cis rs6564851 0.508 rs7199144 chr16:81251846 A/T cg00908271 chr16:81254010 PKD1L2 -0.37 -6.03 -0.32 4.48e-9 Carotenoid and tocopherol levels; CRC cis rs524281 0.773 rs11227413 chr11:65883696 G/A cg14036092 chr11:66035641 RAB1B -0.46 -5.66 -0.3 3.32e-8 Electroencephalogram traits; CRC cis rs79149102 0.579 rs3812943 chr15:75312715 C/G cg09165964 chr15:75287851 SCAMP5 -0.72 -5.74 -0.3 2.18e-8 Lung cancer; CRC cis rs736801 0.740 rs17622378 chr5:131778452 A/G cg21138405 chr5:131827807 IRF1 -0.37 -6.27 -0.33 1.12e-9 Breast cancer;Mosquito bite size; CRC cis rs7917772 0.636 rs1475644 chr10:104491164 G/A cg11453585 chr10:104263688 ACTR1A;SUFU 0.71 10.66 0.51 5.38e-23 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC cis rs1448094 0.511 rs17345272 chr12:86165334 A/C cg25456477 chr12:86230367 RASSF9 0.38 6.32 0.33 8.37e-10 Major depressive disorder; CRC cis rs947211 0.846 rs823155 chr1:205762946 T/C cg14159672 chr1:205819179 PM20D1 0.47 6.73 0.35 7.59e-11 Parkinson's disease; CRC cis rs12681288 0.676 rs935820 chr8:1022168 A/G cg04851639 chr8:1020857 NA -0.38 -8.22 -0.41 4.73e-15 Schizophrenia; CRC cis rs4665809 0.567 rs12999875 chr2:26414847 A/C cg27170947 chr2:26402098 FAM59B 0.6 7.74 0.39 1.21e-13 Gut microbiome composition (summer); CRC cis rs9858542 1.000 rs6770670 chr3:49686682 T/C cg03060546 chr3:49711283 APEH -0.5 -6.78 -0.35 5.72e-11 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs420259 0.510 rs12921516 chr16:23521403 T/G cg00143387 chr16:23521605 GGA2 -0.47 -5.9 -0.31 9.27e-9 Bipolar disorder; CRC trans rs208520 0.754 rs851594 chr6:66876695 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.03 -14.15 -0.62 7.62e-36 Exhaled nitric oxide output; CRC cis rs2730260 0.736 rs73169215 chr7:158833701 T/C cg02254261 chr7:158964346 NA -0.57 -6.36 -0.33 6.6e-10 Myopia (pathological); CRC cis rs10927875 0.929 rs4661674 chr1:16296039 A/G cg24140574 chr1:16342155 HSPB7 -0.41 -5.67 -0.3 3.06e-8 Dilated cardiomyopathy; CRC cis rs10751667 0.666 rs10902243 chr11:949900 T/C cg01483505 chr11:975446 AP2A2 0.45 7.39 0.38 1.24e-12 Alzheimer's disease (late onset); CRC cis rs6502050 0.835 rs7503189 chr17:80099486 C/A cg13198984 chr17:80129470 CCDC57 0.46 8.16 0.41 6.94e-15 Life satisfaction; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg20823940 chr1:95007489 F3 0.47 6.6 0.34 1.69e-10 Response to antipsychotic treatment; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg17121955 chr11:6411382 SMPD1 0.38 6.2 0.32 1.72e-9 Liver disease severity in Alagille syndrome; CRC cis rs40363 0.723 rs757269 chr16:3538003 A/G cg21433313 chr16:3507492 NAT15 -0.68 -6.94 -0.36 2.15e-11 Tuberculosis; CRC cis rs57221529 0.709 rs4957056 chr5:570105 T/C cg14541582 chr5:601475 NA -0.34 -6.71 -0.35 8.72e-11 Lung disease severity in cystic fibrosis; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg20531166 chr11:82782814 RAB30 0.4 5.99 0.31 5.55e-9 Liver disease severity in Alagille syndrome; CRC cis rs6500602 0.592 rs7206782 chr16:4515145 A/C cg08645402 chr16:4508243 NA 0.59 9.13 0.45 7.14e-18 Schizophrenia; CRC cis rs67478160 0.643 rs12880167 chr14:104300829 C/T cg08213375 chr14:104286397 PPP1R13B 0.63 13.04 0.58 1.24e-31 Schizophrenia; CRC cis rs4332037 0.615 rs62435134 chr7:1895463 T/G cg23378565 chr7:2036160 MAD1L1 -0.41 -5.96 -0.31 6.41e-9 Bipolar disorder; CRC cis rs1044826 0.642 rs295479 chr3:139223865 C/T cg00490450 chr3:139108681 COPB2 0.43 6.43 0.33 4.53e-10 Obesity-related traits; CRC cis rs896854 0.738 rs1713669 chr8:95958637 C/G cg23172400 chr8:95962367 TP53INP1 -0.42 -6.43 -0.33 4.43e-10 Type 2 diabetes; CRC cis rs10911232 0.520 rs10797831 chr1:183036816 A/G ch.1.3577855R chr1:183094577 LAMC1 0.82 14.22 0.62 4.34e-36 Hypertriglyceridemia; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg24306924 chr16:46918433 GPT2 0.42 6.29 0.33 1.04e-9 Intelligence (multi-trait analysis); CRC cis rs861020 0.630 rs685248 chr1:210008367 C/G cg05527609 chr1:210001259 C1orf107 0.78 10.9 0.51 8.27e-24 Orofacial clefts; CRC cis rs7937682 0.663 rs35581942 chr11:111756286 C/T cg09085632 chr11:111637200 PPP2R1B 0.95 15.06 0.64 2.3e-39 Primary sclerosing cholangitis; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg03226425 chr6:170151538 C6orf70;TCTE3 0.48 6.31 0.33 9.05e-10 Thyroid stimulating hormone; CRC cis rs477895 0.653 rs11231701 chr11:63893702 G/A cg05016508 chr11:63871570 FLRT1;MACROD1 0.52 6.65 0.34 1.21e-10 Mean platelet volume; CRC cis rs7731657 0.537 rs13355768 chr5:130360245 C/T cg08523029 chr5:130500466 HINT1 -0.46 -5.95 -0.31 6.9e-9 Fasting plasma glucose; CRC cis rs7493 0.950 rs6961624 chr7:95037661 T/C cg19678392 chr7:94953810 PON1 -0.57 -7.2 -0.37 4.21e-12 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs9368481 0.761 rs3931464 chr6:26939856 C/A cg18278486 chr6:26987575 LOC100270746;C6orf41 0.42 6.62 0.34 1.45e-10 Autism spectrum disorder or schizophrenia; CRC cis rs7829975 0.902 rs485107 chr8:8581408 C/G cg06636001 chr8:8085503 FLJ10661 -0.58 -9.21 -0.45 3.83e-18 Mood instability; CRC cis rs6502050 0.835 rs8075086 chr17:80092649 A/G cg13198984 chr17:80129470 CCDC57 0.47 8.43 0.42 1.09e-15 Life satisfaction; CRC cis rs28386778 0.897 rs7501614 chr17:61802612 T/C cg06873352 chr17:61820015 STRADA 0.79 14.79 0.63 2.66e-38 Prudent dietary pattern; CRC trans rs67073037 0.955 rs11677283 chr2:29151035 C/T cg13899017 chr1:159158444 CADM3 -0.36 -6.17 -0.32 2.06e-9 Breast cancer;Breast cancer (estrogen-receptor negative); CRC cis rs4973397 0.774 rs12998237 chr2:232276651 T/C cg13347044 chr2:232276743 NA 0.54 7.67 0.39 1.93e-13 Anti-saccade response; CRC cis rs1865760 0.516 rs9393684 chr6:26075531 G/C cg18357526 chr6:26021779 HIST1H4A 0.41 5.81 0.3 1.5e-8 Height; CRC cis rs1448094 0.842 rs10779231 chr12:86462237 T/C cg02569458 chr12:86230093 RASSF9 -0.4 -6.81 -0.35 4.55e-11 Major depressive disorder; CRC trans rs17685 0.712 rs7778735 chr7:75770237 T/C cg19862616 chr7:65841803 NCRNA00174 0.99 18.11 0.71 2.51e-51 Coffee consumption;Coffee consumption (cups per day); CRC cis rs6502050 0.667 rs9892469 chr17:80093657 T/C cg02741985 chr17:80059408 CCDC57 0.43 7.11 0.36 7.42e-12 Life satisfaction; CRC cis rs2739330 0.828 rs2154593 chr22:24252085 A/G cg04234412 chr22:24373322 LOC391322 -0.72 -11.46 -0.53 8.24e-26 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs6964587 0.967 rs34574955 chr7:91847550 A/C cg17063962 chr7:91808500 NA 0.79 12.27 0.56 9.28e-29 Breast cancer; CRC cis rs10504229 0.683 rs2318144 chr8:58114743 G/A cg08219700 chr8:58056026 NA 0.56 6.81 0.35 4.74e-11 Developmental language disorder (linguistic errors); CRC trans rs7301826 0.627 rs7315707 chr12:131272819 A/G cg05241839 chr16:53537463 AKTIP 0.48 6.19 0.32 1.84e-9 Plasma plasminogen activator levels; CRC cis rs1448094 0.533 rs7955135 chr12:86146350 G/A cg19622623 chr12:86230825 RASSF9 0.4 6.15 0.32 2.22e-9 Major depressive disorder; CRC cis rs6500602 0.627 rs1641866 chr16:4593040 A/C cg08645402 chr16:4508243 NA 0.56 8.87 0.44 4.7e-17 Schizophrenia; CRC cis rs17401966 1.000 rs17396382 chr1:10290268 T/C cg19773385 chr1:10388646 KIF1B -0.54 -6.89 -0.35 2.92e-11 Hepatocellular carcinoma; CRC cis rs1707322 0.613 rs1473840 chr1:46601197 A/G cg03146154 chr1:46216737 IPP -0.49 -6.36 -0.33 6.79e-10 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs11123170 0.640 rs931472 chr2:113969948 C/T cg12889195 chr2:113992843 PAX8;LOC440839;LOC654433 -0.56 -7.61 -0.39 2.92e-13 Renal function-related traits (BUN); CRC cis rs9534288 0.699 rs9534321 chr13:46669032 A/G cg15192986 chr13:46630673 CPB2 -0.64 -8.89 -0.44 4.13e-17 Blood protein levels; CRC cis rs9303280 0.628 rs12939565 chr17:38038389 A/T cg20243544 chr17:37824526 PNMT 0.4 6.34 0.33 7.54e-10 Self-reported allergy; CRC cis rs6860806 0.507 rs273917 chr5:131659618 A/G cg18758796 chr5:131593413 PDLIM4 0.4 6.42 0.33 4.64e-10 Breast cancer; CRC cis rs6860806 0.507 rs272854 chr5:131688017 C/T cg18301423 chr5:131593218 PDLIM4 0.39 6.52 0.34 2.57e-10 Breast cancer; CRC cis rs1568889 1.000 rs11604085 chr11:28141002 G/A cg06544937 chr11:28130018 METT5D1;KIF18A 0.79 11.03 0.52 2.83e-24 Bipolar disorder; CRC cis rs4917833 0.764 rs1925644 chr10:100220488 C/T cg19043522 chr10:100227446 HPSE2 0.37 5.7 0.3 2.71e-8 Pediatric bone mineral density (femoral neck); CRC cis rs877282 0.945 rs11253396 chr10:789754 C/T cg06581033 chr10:766294 NA -0.51 -5.68 -0.3 2.97e-8 Uric acid levels; CRC cis rs3806843 1.000 rs12055222 chr5:140165568 T/C cg19875535 chr5:140030758 IK 0.6 9.79 0.48 4.86e-20 Depressive symptoms (multi-trait analysis); CRC cis rs672059 1.000 rs625917 chr1:183157991 T/G ch.1.3577855R chr1:183094577 LAMC1 0.5 7.29 0.37 2.38e-12 Hypertriglyceridemia; CRC cis rs1862618 0.802 rs194058 chr5:56188977 G/A cg03609598 chr5:56110824 MAP3K1 -0.87 -10.18 -0.49 2.47e-21 Initial pursuit acceleration; CRC cis rs7666738 0.830 rs11726604 chr4:99000969 T/C cg17366294 chr4:99064904 C4orf37 0.44 7.39 0.38 1.19e-12 Colonoscopy-negative controls vs population controls; CRC cis rs2019137 0.868 rs6755639 chr2:113981810 A/G cg21610815 chr2:113994035 PAX8;LOC654433;LOC440839 0.45 6.36 0.33 6.91e-10 Lymphocyte counts; CRC cis rs9372498 0.536 rs9489457 chr6:118920285 C/T cg24463073 chr6:118973353 C6orf204 0.51 6.73 0.35 7.61e-11 Diastolic blood pressure; CRC cis rs11212617 0.967 rs419716 chr11:108221099 G/T cg01991180 chr11:108092276 ATM;NPAT -0.41 -6.14 -0.32 2.43e-9 Response to metformin in type 2 diabetes (glycemic); CRC trans rs1005277 0.579 rs932538 chr10:38381314 T/C cg23533926 chr12:111358616 MYL2 -0.53 -8.19 -0.41 6.02e-15 Extrinsic epigenetic age acceleration; CRC cis rs7647973 0.516 rs4536858 chr3:49193081 A/G cg06212747 chr3:49208901 KLHDC8B 0.39 5.75 0.3 2.09e-8 Menarche (age at onset); CRC cis rs3806843 0.868 rs2563281 chr5:140131219 T/A cg19875535 chr5:140030758 IK -0.53 -8.41 -0.42 1.22e-15 Depressive symptoms (multi-trait analysis); CRC cis rs7811142 1.000 rs112317829 chr7:100043173 A/G cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.89 12.33 0.56 5.45e-29 Platelet count; CRC cis rs826838 0.967 rs7299170 chr12:38789536 G/A cg26384229 chr12:38710491 ALG10B 0.75 10.46 0.5 2.69e-22 Heart rate; CRC cis rs875971 0.830 rs28714531 chr7:65968237 G/A cg18252515 chr7:66147081 NA -0.43 -6.18 -0.32 1.93e-9 Aortic root size; CRC cis rs9303401 0.632 rs7222087 chr17:57221619 A/T cg02118635 chr17:56770003 RAD51C;TEX14 0.44 6.76 0.35 6.39e-11 Cognitive test performance; CRC cis rs11098499 0.954 rs10034623 chr4:120397829 G/A cg09307838 chr4:120376055 NA 0.72 11.33 0.53 2.45e-25 Corneal astigmatism; CRC cis rs67340775 0.541 rs200968 chr6:27859568 T/C cg06470822 chr6:28175283 NA 0.82 8.4 0.42 1.4e-15 Lung cancer in ever smokers; CRC cis rs2032447 0.933 rs4401650 chr6:26035208 G/A cg26028573 chr6:26043587 HIST1H2BB 0.5 7.36 0.38 1.46e-12 Intelligence (multi-trait analysis); CRC cis rs11190604 1.000 rs2003284 chr10:102202338 A/G cg07570687 chr10:102243282 WNT8B 0.44 5.64 0.3 3.61e-8 Palmitoleic acid (16:1n-7) levels; CRC cis rs9372498 0.536 rs72952793 chr6:118892979 T/A cg15382696 chr6:118971807 C6orf204 0.57 7.15 0.37 5.49e-12 Diastolic blood pressure; CRC cis rs12971120 0.891 rs4891557 chr18:72170299 C/T cg25817165 chr18:72167213 CNDP2 -0.63 -8.52 -0.43 5.65e-16 Refractive error; CRC cis rs9322193 0.962 rs3763163 chr6:150140906 G/T cg04369109 chr6:150039330 LATS1 -0.45 -6.14 -0.32 2.44e-9 Lung cancer; CRC cis rs394563 0.967 rs420099 chr6:149794290 A/C cg16235748 chr6:149772707 ZC3H12D -0.38 -6.59 -0.34 1.72e-10 Dupuytren's disease; CRC cis rs6831352 0.734 rs3100630 chr4:100031715 T/A cg12011299 chr4:100065546 ADH4 0.45 8.75 0.43 1.1e-16 Alcohol dependence; CRC cis rs7615952 0.576 rs4646759 chr3:125822946 G/C cg05084668 chr3:125655381 ALG1L -0.45 -6.39 -0.33 5.72e-10 Blood pressure (smoking interaction); CRC cis rs7121446 0.521 rs12278577 chr11:121861838 A/G cg13820391 chr11:121835505 NA 0.32 5.82 0.31 1.4e-8 Cardiovascular risk factors (age interaction); CRC cis rs514406 0.607 rs1930305 chr1:53195481 G/T cg08859206 chr1:53392774 SCP2 0.42 6.46 0.34 3.7e-10 Monocyte count; CRC cis rs873946 0.648 rs3750578 chr10:134563366 A/G cg27286337 chr10:134555280 INPP5A 0.82 10.06 0.48 6.39e-21 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CRC cis rs12474201 0.822 rs897530 chr2:46948150 C/G cg06386533 chr2:46925753 SOCS5 0.77 12.72 0.57 2.09e-30 Height; CRC cis rs17065868 1.000 rs17065995 chr13:45222314 C/T cg10246903 chr13:45222710 NA 0.51 6.21 0.32 1.55e-9 Antineutrophil cytoplasmic antibody-associated vasculitis; CRC cis rs9443645 0.901 rs10455356 chr6:79664748 T/C cg09184832 chr6:79620586 NA -0.51 -9.4 -0.46 9.67e-19 Intelligence (multi-trait analysis); CRC cis rs6951245 0.935 rs11763765 chr7:1060510 C/T cg04025307 chr7:1156635 C7orf50 0.64 6.81 0.35 4.76e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs4780401 0.728 rs4781136 chr16:11767978 G/T cg01061890 chr16:11836724 TXNDC11 -0.41 -5.65 -0.3 3.55e-8 Rheumatoid arthritis; CRC cis rs875971 0.862 rs10950033 chr7:65739673 A/G cg00343986 chr7:65444356 GUSB -0.4 -5.62 -0.3 4.07e-8 Aortic root size; CRC trans rs2727020 0.729 rs34647977 chr11:49195543 G/A cg03929089 chr4:120376271 NA -0.8 -13.49 -0.6 2.49e-33 Coronary artery disease; CRC cis rs2032447 0.798 rs807212 chr6:26065621 A/G cg04800585 chr6:26043546 HIST1H2BB 0.56 8.17 0.41 6.75e-15 Intelligence (multi-trait analysis); CRC trans rs3780486 0.957 rs10971434 chr9:33168891 C/A cg04842962 chr6:43655489 MRPS18A 0.98 14.5 0.62 3.57e-37 IgG glycosylation; CRC cis rs4713118 0.513 rs149972 chr6:27983227 C/T cg12172441 chr6:28176163 NA 0.53 7.42 0.38 9.91e-13 Parkinson's disease; CRC cis rs1707322 0.963 rs4459051 chr1:46451203 A/G cg03146154 chr1:46216737 IPP 0.51 7.06 0.36 1.01e-11 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs651907 0.557 rs35117343 chr3:101445126 A/G cg12386194 chr3:101231763 SENP7 0.5 7.37 0.38 1.42e-12 Colorectal cancer; CRC cis rs9814567 0.806 rs4074523 chr3:134325657 T/G cg06109529 chr3:134205091 CEP63;ANAPC13 -0.67 -9.8 -0.48 4.79e-20 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs9649213 0.593 rs3779194 chr7:98010277 A/G cg24562669 chr7:97807699 LMTK2 0.44 7.2 0.37 3.99e-12 Prostate cancer (SNP x SNP interaction); CRC cis rs6866344 0.697 rs11743893 chr5:178125194 C/T cg03877680 chr5:178157825 ZNF354A 0.72 10.55 0.5 1.35e-22 Neutrophil percentage of white cells; CRC trans rs7726839 0.561 rs11955068 chr5:582324 C/T cg25482853 chr8:67687455 SGK3 1.01 12.16 0.56 2.48e-28 Obesity-related traits; CRC cis rs7945705 0.902 rs10769980 chr11:9014180 G/A cg14711859 chr11:8959438 ASCL3 -0.43 -6.93 -0.36 2.21e-11 Hemoglobin concentration; CRC cis rs1190552 0.846 rs12883789 chr14:102954621 G/A cg18135206 chr14:102964638 TECPR2 0.54 6.35 0.33 7.21e-10 Blood protein levels; CRC cis rs727563 0.635 rs2899348 chr22:42164516 C/G cg03806693 chr22:41940476 POLR3H 1.1 13.52 0.6 2e-33 Crohn's disease;Inflammatory bowel disease; CRC trans rs2727020 0.724 rs4109837 chr11:49372051 A/T cg03929089 chr4:120376271 NA -0.73 -9.8 -0.48 4.69e-20 Coronary artery disease; CRC cis rs7089973 0.604 rs55759483 chr10:116573423 T/C cg23260525 chr10:116636907 FAM160B1 0.4 9.21 0.45 3.91e-18 Bipolar disorder or attention deficit hyperactivity disorder; CRC cis rs7666738 0.830 rs28622458 chr4:98916651 A/G cg05340658 chr4:99064831 C4orf37 0.57 8.54 0.43 5.08e-16 Colonoscopy-negative controls vs population controls; CRC trans rs208520 0.661 rs7747492 chr6:66857788 A/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.05 -14.78 -0.63 3.02e-38 Exhaled nitric oxide output; CRC cis rs939658 0.935 rs954292 chr15:79449237 C/T cg17916960 chr15:79447300 NA 0.47 7.85 0.4 5.77e-14 Refractive error; CRC cis rs2408955 0.522 rs4760679 chr12:48461635 G/T cg24011408 chr12:48396354 COL2A1 -0.43 -6.38 -0.33 6e-10 Glycated hemoglobin levels; CRC cis rs11645898 0.810 rs11646364 chr16:72108687 A/T cg14768367 chr16:72042858 DHODH -0.7 -7.22 -0.37 3.69e-12 Blood protein levels; CRC cis rs4713118 0.513 rs149975 chr6:27986340 G/A cg06470822 chr6:28175283 NA 0.82 12.33 0.56 5.58e-29 Parkinson's disease; CRC cis rs16852403 0.548 rs1018706 chr1:178209895 T/G cg00404053 chr1:178313656 RASAL2 0.5 6.53 0.34 2.55e-10 Childhood ear infection; CRC cis rs1799949 0.930 rs33968979 chr17:41297992 G/T cg01879757 chr17:41196368 BRCA1 -0.44 -6.67 -0.35 1.06e-10 Menopause (age at onset); CRC cis rs11098499 0.909 rs6842762 chr4:120398236 A/T cg09307838 chr4:120376055 NA 0.71 11.12 0.52 1.39e-24 Corneal astigmatism; CRC cis rs1707322 1.000 rs7527079 chr1:46413450 C/G cg03146154 chr1:46216737 IPP 0.51 7.12 0.37 6.96e-12 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs4561483 0.798 rs33629 chr16:11997490 G/A cg08843971 chr16:11963173 GSPT1 -0.62 -9.08 -0.45 1e-17 Testicular germ cell tumor; CRC cis rs10883723 0.773 rs11191313 chr10:104278618 C/T cg22532475 chr10:104410764 TRIM8 -0.38 -6.77 -0.35 5.93e-11 Allergic disease (asthma, hay fever or eczema); CRC cis rs4660261 0.545 rs803682 chr1:44362623 G/A cg12908607 chr1:44402522 ARTN -0.55 -10.13 -0.49 3.64e-21 Intelligence (multi-trait analysis); CRC cis rs2115630 1.000 rs6496452 chr15:85372645 A/T cg12501888 chr15:85177176 SCAND2 -0.37 -6.18 -0.32 1.9e-9 P wave terminal force; CRC cis rs62064224 0.714 rs8074594 chr17:30632998 G/A cg18200150 chr17:30822561 MYO1D 0.47 9.52 0.46 3.96e-19 Schizophrenia; CRC cis rs9660180 0.839 rs12040826 chr1:1705287 A/C cg05132306 chr1:1846340 CALML6 -0.44 -6.74 -0.35 6.98e-11 Body mass index; CRC cis rs3862030 0.500 rs11191327 chr10:104303883 T/C cg22532475 chr10:104410764 TRIM8 -0.36 -6.61 -0.34 1.58e-10 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for body mass index; CRC cis rs4481887 0.893 rs4529743 chr1:248473683 G/C cg00666640 chr1:248458726 OR2T12 0.45 7.8 0.4 8.31e-14 Common traits (Other); CRC cis rs2075371 0.932 rs2544215 chr7:133987896 T/C cg20476274 chr7:133979776 SLC35B4 0.81 14.97 0.64 5.12e-39 Mean platelet volume; CRC cis rs3806843 0.735 rs2563314 chr5:140047289 A/G cg19875535 chr5:140030758 IK -0.64 -10.71 -0.51 3.54e-23 Depressive symptoms (multi-trait analysis); CRC trans rs67073037 0.955 rs4371318 chr2:29156360 T/C cg13899017 chr1:159158444 CADM3 -0.37 -6.23 -0.32 1.39e-9 Breast cancer;Breast cancer (estrogen-receptor negative); CRC cis rs7923609 0.967 rs7082470 chr10:65277026 G/A cg08743896 chr10:65200160 JMJD1C -0.42 -5.96 -0.31 6.65e-9 Educational attainment;Liver enzyme levels (alkaline phosphatase); CRC cis rs9818758 0.556 rs13086240 chr3:49001409 G/A cg07636037 chr3:49044803 WDR6 -0.82 -6.7 -0.35 9.21e-11 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; CRC cis rs801193 1.000 rs7783924 chr7:66209057 A/C cg18876405 chr7:65276391 NA 0.6 10.61 0.51 7.98e-23 Aortic root size; CRC cis rs2204008 0.805 rs4589389 chr12:37946120 C/A cg26384229 chr12:38710491 ALG10B -0.62 -9.42 -0.46 8.23e-19 Bladder cancer; CRC cis rs28655083 0.529 rs285027 chr16:77100932 A/G cg01753188 chr16:77233325 SYCE1L;MON1B 0.47 6.6 0.34 1.64e-10 Lobe attachment (rater-scored or self-reported); CRC cis rs35306767 0.903 rs7074642 chr10:878359 A/G cg20503657 chr10:835505 NA 0.91 11.3 0.53 2.97e-25 Eosinophil percentage of granulocytes; CRC cis rs116095464 0.558 rs9312957 chr5:202194 C/T cg22857025 chr5:266934 NA -1.12 -12.24 -0.56 1.17e-28 Breast cancer; CRC cis rs12143943 0.934 rs1870551 chr1:204581014 A/G cg17419461 chr1:204415978 PIK3C2B 0.4 6.08 0.32 3.25e-9 Cognitive performance; CRC cis rs4889855 0.530 rs4889863 chr17:78550468 C/T cg16591659 chr17:78472290 NA -0.4 -5.74 -0.3 2.13e-8 Fractional excretion of uric acid; CRC cis rs2456568 0.803 rs10831138 chr11:93640468 T/C cg26875233 chr11:93583750 C11orf90 -0.31 -6.02 -0.32 4.6e-9 Response to serotonin reuptake inhibitors in major depressive disorder; CRC cis rs57221529 0.608 rs11749927 chr5:668842 C/T cg16447950 chr5:562315 NA -0.64 -9.17 -0.45 5.11e-18 Lung disease severity in cystic fibrosis; CRC cis rs80033912 0.640 rs6785832 chr3:49224316 C/T cg03060546 chr3:49711283 APEH 0.46 6.28 0.33 1.04e-9 Intelligence (multi-trait analysis); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg00804031 chr19:4007535 PIAS4 0.42 6.27 0.33 1.14e-9 Intelligence (multi-trait analysis); CRC cis rs853679 0.517 rs1947863 chr6:28099344 G/A cg03623178 chr6:28175578 NA 0.96 12.57 0.57 7.23e-30 Depression; CRC cis rs853679 0.550 rs1233704 chr6:28166923 A/G cg21251018 chr6:28226885 NKAPL -0.46 -6.58 -0.34 1.88e-10 Depression; CRC cis rs7618501 0.602 rs2301166 chr3:50148305 C/G cg24308560 chr3:49941425 MST1R 0.49 8.19 0.41 5.98e-15 Intelligence (multi-trait analysis); CRC cis rs2288912 0.838 rs2239375 chr19:45459851 T/C cg13119609 chr19:45449297 APOC2 0.31 5.86 0.31 1.14e-8 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs1881797 0.872 rs2141544 chr1:247690800 A/G cg05639522 chr1:247681581 NA 0.48 8.09 0.41 1.17e-14 Acute lymphoblastic leukemia (childhood); CRC cis rs2839186 0.616 rs4819213 chr21:47619300 G/A cg13012494 chr21:47604986 C21orf56 -0.48 -7.78 -0.39 9.72e-14 Testicular germ cell tumor; CRC cis rs10752881 1.000 rs10911190 chr1:182979080 C/T ch.1.3577855R chr1:183094577 LAMC1 0.87 15.17 0.64 8.98e-40 Colorectal cancer; CRC cis rs758324 0.891 rs491624 chr5:131270222 A/T cg06307176 chr5:131281290 NA -0.42 -6.32 -0.33 8.63e-10 Alzheimer's disease in APOE e4- carriers; CRC trans rs1814175 0.765 rs1794141 chr11:49914135 G/C cg21153622 chr11:89784906 NA -0.37 -5.99 -0.31 5.61e-9 Height; CRC cis rs1322512 0.917 rs2623956 chr6:152971617 G/A cg03415253 chr6:152958462 SYNE1 -0.44 -6.75 -0.35 6.68e-11 Tonometry; CRC cis rs2404602 0.716 rs7164060 chr15:76707694 T/C cg03037974 chr15:76606532 NA 0.72 13.12 0.59 6.35e-32 Blood metabolite levels; CRC cis rs7527798 0.592 rs12411037 chr1:207857158 T/C cg09232269 chr1:207846808 CR1L -0.48 -7.87 -0.4 5.04e-14 Erythrocyte sedimentation rate; CRC cis rs11190604 1.000 rs2489039 chr10:102328036 T/A cg07080220 chr10:102295463 HIF1AN 0.45 5.73 0.3 2.29e-8 Palmitoleic acid (16:1n-7) levels; CRC cis rs802075 0.905 rs7746868 chr6:49642763 A/C cg20364632 chr6:49636226 NA 0.36 6.01 0.31 4.86e-9 Bone mineral density (hip) and age at menarche; CRC cis rs13118159 0.556 rs4974615 chr4:1373551 A/G cg19318889 chr4:1322082 MAEA -0.66 -10.07 -0.49 5.76e-21 Longevity; CRC cis rs7113874 0.524 rs10743076 chr11:8560571 C/A cg17679104 chr11:8615758 STK33 -0.36 -5.96 -0.31 6.52e-9 Body mass index in physically active individuals;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs12325245 0.536 rs34161389 chr16:58622604 G/A cg21335942 chr16:58549945 SETD6 0.86 5.72 0.3 2.39e-8 Schizophrenia; CRC cis rs6693567 0.565 rs1260458 chr1:150347454 C/T cg15654264 chr1:150340011 RPRD2 0.38 5.95 0.31 7.02e-9 Migraine; CRC cis rs1448094 0.511 rs61930588 chr12:86158991 A/G cg00310523 chr12:86230176 RASSF9 0.38 6.08 0.32 3.31e-9 Major depressive disorder; CRC cis rs10504229 0.728 rs72650861 chr8:58153273 T/C cg24829409 chr8:58192753 C8orf71 -0.58 -7.96 -0.4 2.86e-14 Developmental language disorder (linguistic errors); CRC cis rs11098499 0.866 rs13105020 chr4:120285688 G/T cg24375607 chr4:120327624 NA 0.48 7.44 0.38 8.79e-13 Corneal astigmatism; CRC cis rs71227278 1 rs71227278 chr12:54358047 C/CTTAA cg01524278 chr12:54355460 NA 0.39 7.69 0.39 1.75e-13 Urinary tract infection frequency; CRC cis rs11723261 0.527 rs11731581 chr4:87932 A/G cg12746427 chr4:53362 ZNF718;ZNF595 0.56 8.36 0.42 1.79e-15 Immune response to smallpox vaccine (IL-6); CRC cis rs67311347 0.544 rs13097602 chr3:40339247 T/C cg09455208 chr3:40491958 NA -0.31 -6.3 -0.33 9.41e-10 Renal cell carcinoma; CRC cis rs6502050 0.835 rs7219138 chr17:80079896 C/T cg09264619 chr17:80180166 NA 0.37 6.13 0.32 2.47e-9 Life satisfaction; CRC cis rs1799949 1.000 rs8176212 chr17:41226601 G/C cg23758822 chr17:41437982 NA 0.81 13.72 0.6 3.54e-34 Menopause (age at onset); CRC cis rs1816752 0.905 rs9511262 chr13:25012023 C/T cg02811702 chr13:24901961 NA 0.47 6.6 0.34 1.64e-10 Obesity-related traits; CRC cis rs4665809 0.556 rs6730311 chr2:26419474 C/T cg22920501 chr2:26401640 FAM59B -0.81 -11.52 -0.54 4.9e-26 Gut microbiome composition (summer); CRC cis rs13108904 0.875 rs73069950 chr4:1276045 C/A cg00684032 chr4:1343700 KIAA1530 -0.42 -6.32 -0.33 8.47e-10 Obesity-related traits; CRC cis rs6502050 0.761 rs7225637 chr17:80059758 A/G cg19223190 chr17:80058835 NA 0.48 7.69 0.39 1.75e-13 Life satisfaction; CRC cis rs2797160 0.904 rs2326292 chr6:125999674 G/A cg05901451 chr6:126070800 HEY2 -0.38 -5.74 -0.3 2.16e-8 Endometrial cancer; CRC cis rs55871839 0.708 rs10098750 chr8:59813205 T/G cg07426533 chr8:59803705 TOX -0.34 -5.94 -0.31 7.22e-9 Pneumonia; CRC cis rs875971 1.000 rs9986696 chr7:65704576 C/A cg18876405 chr7:65276391 NA -0.53 -9.11 -0.45 8.28e-18 Aortic root size; CRC cis rs7493 0.950 rs17166868 chr7:95033416 C/T cg20119798 chr7:94954144 PON1 -0.51 -6.4 -0.33 5.35e-10 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs7666738 0.830 rs59751489 chr4:98933802 A/G cg05340658 chr4:99064831 C4orf37 0.6 9.35 0.46 1.41e-18 Colonoscopy-negative controls vs population controls; CRC cis rs9916302 0.861 rs8079590 chr17:37426201 T/C cg03013999 chr17:37608204 MED1 0.48 7.39 0.38 1.24e-12 Glomerular filtration rate (creatinine); CRC cis rs9914988 0.943 rs4262997 chr17:27129562 A/G cg07195577 chr17:27052828 TLCD1 0.42 6.02 0.32 4.64e-9 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs8180040 0.932 rs11712445 chr3:47434552 T/C cg02527881 chr3:46936655 PTH1R -0.39 -7.46 -0.38 7.55e-13 Colorectal cancer; CRC cis rs300703 0.515 rs300693 chr2:181748 C/A cg21211680 chr2:198530 NA -0.71 -9.44 -0.46 6.94e-19 Blood protein levels; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg22129074 chr11:74204105 LIPT2 0.47 6.1 0.32 3.04e-9 Thyroid stimulating hormone; CRC cis rs116095464 0.558 rs9312977 chr5:221916 G/C cg22857025 chr5:266934 NA -1.23 -16.9 -0.68 1.4300000000000001e-46 Breast cancer; CRC cis rs62229266 0.659 rs2835243 chr21:37413946 C/T cg12218747 chr21:37451666 NA -0.37 -6.21 -0.32 1.62e-9 Mitral valve prolapse; CRC trans rs35110281 0.782 rs1584917 chr21:45042365 A/G cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.48 7.9 0.4 4.2e-14 Mean corpuscular volume; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg04720635 chr5:118604540 TNFAIP8 0.39 6.19 0.32 1.76e-9 Intelligence (multi-trait analysis); CRC trans rs561341 0.714 rs55925849 chr17:30253085 C/T cg27661571 chr11:113659931 NA -0.96 -11.1 -0.52 1.56e-24 Hip circumference adjusted for BMI; CRC cis rs4713118 0.824 rs7759217 chr6:27730463 A/G cg06470822 chr6:28175283 NA 0.72 9.7 0.47 1e-19 Parkinson's disease; CRC cis rs4332037 0.906 rs62442903 chr7:1953416 G/A cg23378565 chr7:2036160 MAD1L1 -0.42 -5.9 -0.31 8.98e-9 Bipolar disorder; CRC cis rs79839061 0.610 rs2279182 chr4:882625 T/G cg07828340 chr4:882639 GAK 1.1 11.62 0.54 2.23e-26 Intelligence (multi-trait analysis); CRC cis rs728616 0.867 rs4633405 chr10:81927446 G/T cg11900509 chr10:81946545 ANXA11 -0.71 -7.17 -0.37 4.83e-12 Chronic obstructive pulmonary disease-related biomarkers; CRC trans rs1493916 1.000 rs4799729 chr18:31393521 C/T cg27147174 chr7:100797783 AP1S1 0.4 6.43 0.33 4.41e-10 Life satisfaction; CRC cis rs12134245 0.776 rs12122066 chr1:92005140 C/T cg25838465 chr1:92012736 NA -0.67 -12.39 -0.56 3.32e-29 Breast cancer; CRC trans rs4478147 0.591 rs56353461 chr4:87470983 A/G cg01215037 chr19:50083917 PRRG2;NOSIP 0.45 5.97 0.31 6.1e-9 Migraine - clinic-based; CRC cis rs6963495 0.818 rs73190186 chr7:105164368 G/C cg02135003 chr7:105160482 PUS7 -0.9 -12.2 -0.56 1.71e-28 Bipolar disorder (body mass index interaction); CRC cis rs4692589 0.606 rs12645495 chr4:170933909 T/C cg19918862 chr4:170955249 NA 0.52 6.98 0.36 1.62e-11 Anxiety disorder; CRC cis rs1697139 0.583 rs13186050 chr5:66528139 C/T cg11553311 chr5:66541588 NA 0.59 9.97 0.48 1.28e-20 Breast cancer; CRC cis rs6912958 0.781 rs7750207 chr6:88303967 A/C cg12350822 chr6:88032061 C6orf162;GJB7 -0.34 -6.37 -0.33 6.44e-10 Monocyte percentage of white cells; CRC cis rs3820068 0.581 rs58567918 chr1:15925823 A/G cg27534772 chr1:16042836 PLEKHM2 0.54 10.49 0.5 2.13e-22 Systolic blood pressure; CRC cis rs909002 0.849 rs6663012 chr1:32091779 T/G cg13919466 chr1:32135498 COL16A1 -0.32 -6.22 -0.32 1.5e-9 Intelligence (multi-trait analysis); CRC cis rs4665809 1.000 rs13030858 chr2:26315451 G/A cg04944784 chr2:26401820 FAM59B -0.6 -7.77 -0.39 1.01e-13 Gut microbiome composition (summer); CRC cis rs9660180 0.967 rs6603802 chr1:1812521 C/T cg23982607 chr1:1823379 GNB1 -0.91 -17.1 -0.69 2.38e-47 Body mass index; CRC cis rs6502050 0.799 rs4132775 chr17:80155412 C/T cg02741985 chr17:80059408 CCDC57 0.43 7.17 0.37 4.94e-12 Life satisfaction; CRC cis rs1670533 1.000 rs2100411 chr4:1074412 T/C cg27284194 chr4:1044797 NA 0.49 6.24 0.33 1.37e-9 Recombination rate (females); CRC cis rs2839186 0.605 rs2839174 chr21:47676934 T/C cg12516959 chr21:47718080 NA -0.33 -5.65 -0.3 3.57e-8 Testicular germ cell tumor; CRC cis rs9372498 0.536 rs62424195 chr6:118812108 T/A cg10217327 chr6:118973057 C6orf204 0.5 5.69 0.3 2.83e-8 Diastolic blood pressure; CRC cis rs9522267 0.535 rs2039916 chr13:112238863 A/C cg10483660 chr13:112241077 NA -0.5 -9.77 -0.47 5.89e-20 Hepatitis; CRC cis rs11098499 0.690 rs34818745 chr4:120257055 T/C cg09307838 chr4:120376055 NA 0.67 9.67 0.47 1.21e-19 Corneal astigmatism; CRC cis rs35306767 0.761 rs12770910 chr10:1050318 A/G cg20503657 chr10:835505 NA 0.93 11.11 0.52 1.43e-24 Eosinophil percentage of granulocytes; CRC cis rs9372498 0.536 rs55899435 chr6:118812099 C/T cg10217327 chr6:118973057 C6orf204 0.5 5.69 0.3 2.83e-8 Diastolic blood pressure; CRC cis rs9322193 0.923 rs9479810 chr6:150072495 C/T cg05861140 chr6:150128134 PCMT1 -0.44 -7.23 -0.37 3.34e-12 Lung cancer; CRC cis rs477895 0.653 rs11603212 chr11:63927810 C/T cg23719950 chr11:63933701 MACROD1 0.66 8.35 0.42 1.93e-15 Mean platelet volume; CRC cis rs2073300 0.609 rs3746733 chr20:23349749 C/T cg12062639 chr20:23401060 NAPB 0.64 6.34 0.33 7.74e-10 Peripheral arterial disease (traffic-related air pollution interaction); CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg24340285 chr19:1095545 POLR2E 0.37 6.08 0.32 3.25e-9 Obesity-related traits; CRC cis rs6952808 0.500 rs3800902 chr7:2144378 C/T cg04267008 chr7:1944627 MAD1L1 -0.67 -9.29 -0.46 2.17e-18 Bipolar disorder and schizophrenia; CRC cis rs7666738 0.830 rs1426669 chr4:98945534 C/T cg17366294 chr4:99064904 C4orf37 0.43 7.33 0.37 1.81e-12 Colonoscopy-negative controls vs population controls; CRC cis rs1552244 0.608 rs6764807 chr3:9998803 T/C cg02579736 chr3:10068473 FANCD2;CIDECP 0.65 9.23 0.45 3.51e-18 Alzheimer's disease; CRC cis rs2836950 0.527 rs2836948 chr21:40599677 T/C cg11644478 chr21:40555479 PSMG1 -0.51 -7.58 -0.39 3.48e-13 Menarche (age at onset); CRC cis rs561341 0.609 rs9906443 chr17:30185565 C/T cg12193833 chr17:30244370 NA 0.46 6.12 0.32 2.61e-9 Hip circumference adjusted for BMI; CRC cis rs7618915 0.570 rs11130312 chr3:52675055 A/C cg08222913 chr3:52553049 STAB1 -0.34 -6.14 -0.32 2.4e-9 Bipolar disorder; CRC cis rs763014 0.932 rs2384972 chr16:674424 G/A cg03804128 chr16:635623 NA 0.31 7.07 0.36 9.35e-12 Height; CRC cis rs853679 0.517 rs16893666 chr6:28054707 C/T cg23161317 chr6:28129485 ZNF389 -0.5 -6.16 -0.32 2.15e-9 Depression; CRC cis rs1448094 0.511 rs17280643 chr12:86210154 C/T cg18827107 chr12:86230957 RASSF9 0.37 6.09 0.32 3.19e-9 Major depressive disorder; CRC cis rs10504229 0.516 rs60398072 chr8:58086559 G/A cg21724239 chr8:58056113 NA 0.7 12.98 0.58 2.14e-31 Developmental language disorder (linguistic errors); CRC trans rs6703335 0.870 rs10803142 chr1:243598234 A/G cg03924805 chr2:242211663 HDLBP 0.44 6.32 0.33 8.53e-10 Schizophrenia;Schizophrenia, schizoaffective disorder or bipolar disorder; CRC cis rs853679 0.517 rs9357063 chr6:28060005 G/A cg02631126 chr6:28058918 ZSCAN12L1 0.3 6.09 0.32 3.12e-9 Depression; CRC cis rs989128 0.600 rs8082568 chr17:48629312 G/C cg16068336 chr17:48637367 CACNA1G -0.51 -7.4 -0.38 1.12e-12 Type 2 diabetes; CRC cis rs344364 0.511 rs1657144 chr16:1963989 C/A cg14074117 chr16:1909714 C16orf73 0.41 5.79 0.3 1.63e-8 Glomerular filtration rate in chronic kidney disease; CRC cis rs9611565 0.545 rs5758432 chr22:42111693 T/C cg03806693 chr22:41940476 POLR3H 1.04 12.82 0.58 8.95e-31 Vitiligo; CRC cis rs11212617 1.000 rs680113 chr11:108165406 G/A cg12106634 chr11:108092400 ATM;NPAT 0.42 6.07 0.32 3.56e-9 Response to metformin in type 2 diabetes (glycemic); CRC cis rs4665809 0.556 rs1560869 chr2:26417095 T/C cg27170947 chr2:26402098 FAM59B -0.59 -7.62 -0.39 2.79e-13 Gut microbiome composition (summer); CRC cis rs75920871 0.588 rs6589587 chr11:116875338 T/G cg01368799 chr11:117014884 PAFAH1B2 -0.43 -6.01 -0.31 4.8e-9 Subjective well-being; CRC cis rs950027 0.620 rs1346267 chr15:45690989 A/G cg10760299 chr15:45669010 GATM 0.37 5.69 0.3 2.74e-8 Response to fenofibrate (adiponectin levels); CRC trans rs797680 0.856 rs6541404 chr1:93743434 A/T cg10096100 chr1:26503862 CNKSR1 0.25 6.8 0.35 4.95e-11 Eosinophil percentage of white cells;Sum eosinophil basophil counts; CRC cis rs801193 0.527 rs2707837 chr7:66181073 G/C cg12463550 chr7:65579703 CRCP 0.46 6.19 0.32 1.81e-9 Aortic root size; CRC trans rs9291683 0.655 rs55941493 chr4:10100341 G/A cg26043149 chr18:55253948 FECH -0.51 -7.85 -0.4 5.93e-14 Bone mineral density; CRC cis rs8060686 0.641 rs113258243 chr16:68086656 C/T cg26727032 chr16:67993705 SLC12A4 -0.59 -6.7 -0.35 9.01e-11 HDL cholesterol;Metabolic syndrome; CRC cis rs950169 0.519 rs7237 chr15:85186577 C/T cg17507749 chr15:85114479 UBE2QP1 0.6 8.24 0.41 4.15e-15 Schizophrenia; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg05878849 chr19:40971639 SPTBN4;BLVRB 0.47 6.44 0.33 4.24e-10 Anxiety disorder; CRC cis rs863345 0.604 rs11264983 chr1:158462218 A/C cg12129480 chr1:158549410 OR10X1 -0.29 -6.04 -0.32 4.2e-9 Pneumococcal bacteremia; CRC cis rs854572 0.870 rs757158 chr7:94955528 C/T cg21856205 chr7:94953877 PON1 -0.7 -11.77 -0.54 6.33e-27 Paraoxonase activity; CRC cis rs12620999 0.774 rs13402764 chr2:237951984 C/T cg23555395 chr2:238036564 NA -0.47 -7.4 -0.38 1.13e-12 Systemic lupus erythematosus; CRC cis rs6570726 0.791 rs435671 chr6:145881215 A/G cg05347473 chr6:146136440 FBXO30 0.4 6.1 0.32 2.95e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs9393692 0.875 rs6939589 chr6:26289203 C/T cg05868516 chr6:26286170 HIST1H4H -0.38 -5.65 -0.3 3.47e-8 Educational attainment; CRC cis rs1865760 0.566 rs1800702 chr6:26086463 C/G cg18357526 chr6:26021779 HIST1H4A 0.43 6.09 0.32 3.08e-9 Height; CRC cis rs9733 0.818 rs11204695 chr1:150657011 T/G cg18016565 chr1:150552671 MCL1 -0.42 -6.22 -0.32 1.5e-9 Tonsillectomy; CRC cis rs5750830 0.621 rs743838 chr22:39824707 T/G cg05872129 chr22:39784769 NA -0.57 -9.86 -0.48 2.99e-20 Intelligence (multi-trait analysis); CRC cis rs2727020 0.521 rs937430 chr11:49542457 A/G cg27395922 chr11:50257633 LOC441601 0.36 5.87 0.31 1.07e-8 Coronary artery disease; CRC cis rs4132509 1.000 rs10927040 chr1:243731693 T/C cg21452805 chr1:244014465 NA 0.47 6.38 0.33 5.99e-10 RR interval (heart rate); CRC cis rs17270561 0.609 rs9358871 chr6:25726675 G/A cg16482183 chr6:26056742 HIST1H1C 0.83 10.59 0.5 9.49e-23 Iron status biomarkers; CRC cis rs4954585 0.683 rs11678502 chr2:136994454 C/T cg05194412 chr2:137003533 NA 0.42 6.7 0.35 8.98e-11 Colorectal cancer; CRC cis rs17095355 1.000 rs734165 chr10:111697789 C/T cg00817464 chr10:111662876 XPNPEP1 -0.53 -6.47 -0.34 3.59e-10 Biliary atresia; CRC cis rs6495122 0.618 rs4886413 chr15:75262310 G/C cg21523564 chr15:75251491 NA 0.42 6.12 0.32 2.65e-9 Caffeine consumption;Diastolic blood pressure;Coffee consumption; CRC cis rs847577 0.588 rs12666406 chr7:97790991 G/A cg24562669 chr7:97807699 LMTK2 0.79 17.53 0.69 4.85e-49 Breast cancer; CRC trans rs875971 0.545 rs66594357 chr7:65792784 G/A cg02869306 chr7:64672164 INTS4L1 -0.44 -6.47 -0.34 3.62e-10 Aortic root size; CRC trans rs10982213 0.830 rs2274163 chr9:117188714 C/T cg14293776 chr19:12371199 NA 0.41 6.11 0.32 2.89e-9 Interleukin-6 levels; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg00984370 chr22:50946470 LMF2;NCAPH2 0.43 6.16 0.32 2.07e-9 Intelligence (multi-trait analysis); CRC cis rs9311474 0.508 rs17052259 chr3:52593138 A/G cg05573699 chr3:52720067 GNL3;PBRM1 -0.44 -6.45 -0.33 4.06e-10 Electroencephalogram traits; CRC cis rs9811920 0.609 rs6765027 chr3:99687730 A/G cg07805332 chr3:99536008 MIR548G;C3orf26 0.51 7.68 0.39 1.84e-13 Axial length; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg16215968 chr13:30995686 NA 0.42 6.48 0.34 3.26e-10 Intelligence (multi-trait analysis); CRC cis rs7829975 0.714 rs4841042 chr8:8664622 A/G cg08975724 chr8:8085496 FLJ10661 -0.4 -6.32 -0.33 8.51e-10 Mood instability; CRC cis rs1552244 1.000 rs9827740 chr3:10120531 T/C cg02579736 chr3:10068473 FANCD2;CIDECP 0.97 13.2 0.59 3.17e-32 Alzheimer's disease; CRC cis rs4332037 0.539 rs56180486 chr7:2050747 C/T cg23422044 chr7:1970798 MAD1L1 -0.58 -6.92 -0.36 2.34e-11 Bipolar disorder; CRC cis rs68170813 0.523 rs11762152 chr7:106811374 G/A cg02696742 chr7:106810147 HBP1 -0.64 -7.32 -0.37 1.94e-12 Coronary artery disease; CRC cis rs936229 0.768 rs11072509 chr15:75114374 C/G cg14664628 chr15:75095509 CSK -1.01 -19.49 -0.73 8.97e-57 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); CRC cis rs4481887 1.000 rs4409693 chr1:248479061 C/T cg13385794 chr1:248469461 NA 0.4 6.85 0.35 3.58e-11 Common traits (Other); CRC cis rs1881797 1.000 rs12061460 chr1:247686787 G/A cg21399703 chr1:247681439 NA 0.47 7.65 0.39 2.24e-13 Acute lymphoblastic leukemia (childhood); CRC cis rs8180040 0.764 rs62246375 chr3:47014464 G/A cg02527881 chr3:46936655 PTH1R 0.41 7.36 0.38 1.49e-12 Colorectal cancer; CRC cis rs6696846 0.765 rs11240360 chr1:205083865 T/C cg00857998 chr1:205179979 DSTYK 0.46 6.31 0.33 8.9e-10 Red blood cell count; CRC cis rs10979 0.679 rs2275345 chr6:143872960 G/A cg25407410 chr6:143891975 LOC285740 -0.68 -9.39 -0.46 1.02e-18 Hypospadias; CRC cis rs1448094 0.511 rs1993807 chr12:86146833 A/G cg02569458 chr12:86230093 RASSF9 -0.48 -8.08 -0.41 1.27e-14 Major depressive disorder; CRC cis rs11105298 0.786 rs10858867 chr12:89851166 C/T cg00757033 chr12:89920650 WDR51B 0.37 6.13 0.32 2.52e-9 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; CRC trans rs3733585 0.673 rs4447861 chr4:9953940 C/T cg26043149 chr18:55253948 FECH -0.5 -7.71 -0.39 1.51e-13 Cleft plate (environmental tobacco smoke interaction); CRC cis rs6834538 0.559 rs10434014 chr4:113401357 C/A cg10021238 chr4:113569128 MIR367;LARP7 -0.39 -5.75 -0.3 2.02e-8 Free thyroxine concentration; CRC cis rs2404602 0.735 rs56246286 chr15:76690731 C/T cg23625390 chr15:77176239 SCAPER -0.83 -13.22 -0.59 2.59e-32 Blood metabolite levels; CRC cis rs6762 0.719 rs28655651 chr11:837121 G/C cg11173246 chr11:841376 TSPAN4;POLR2L -0.34 -5.77 -0.3 1.87e-8 Mean platelet volume; CRC cis rs3858526 0.523 rs10838749 chr11:5884246 A/G cg13902645 chr11:5959945 NA -0.67 -9.41 -0.46 8.91e-19 DNA methylation (variation); CRC cis rs6963495 0.818 rs73192143 chr7:105202415 A/G cg02135003 chr7:105160482 PUS7 -0.97 -12.57 -0.57 7.19e-30 Bipolar disorder (body mass index interaction); CRC cis rs4713118 0.869 rs7773070 chr6:27728827 T/C cg19041857 chr6:27730383 NA -0.41 -5.93 -0.31 7.57e-9 Parkinson's disease; CRC cis rs11190604 1.000 rs2495751 chr10:102327260 A/G cg16342193 chr10:102329863 NA -0.35 -5.94 -0.31 7.41e-9 Palmitoleic acid (16:1n-7) levels; CRC trans rs1326986 0.702 rs12252209 chr10:19825426 T/G cg02718124 chr11:6502648 FXC1;ARFIP2 0.58 5.97 0.31 6e-9 Ankylosing spondylitis; CRC cis rs9399137 0.507 rs11753673 chr6:135316476 T/C cg22676075 chr6:135203613 NA 0.59 9.01 0.45 1.66e-17 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; CRC cis rs7927771 0.507 rs11039432 chr11:47873327 G/A cg20307385 chr11:47447363 PSMC3 0.45 6.62 0.34 1.48e-10 Subjective well-being; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg19148051 chr1:3713096 LRRC47 0.43 6.05 0.32 3.88e-9 Response to antipsychotic treatment; CRC trans rs66887589 0.934 rs7672519 chr4:120544112 C/T cg25214090 chr10:38739885 LOC399744 -0.42 -6.54 -0.34 2.37e-10 Diastolic blood pressure; CRC cis rs875971 0.862 rs778720 chr7:65846275 A/C cg11764359 chr7:65958608 NA -0.57 -8.87 -0.44 4.62e-17 Aortic root size; CRC cis rs6570726 0.935 rs371744 chr6:145841024 C/T cg05347473 chr6:146136440 FBXO30 0.36 5.7 0.3 2.73e-8 Lobe attachment (rater-scored or self-reported); CRC cis rs1552244 0.882 rs9312044 chr3:10037481 T/C cg13047869 chr3:10149882 C3orf24 0.48 6.81 0.35 4.79e-11 Alzheimer's disease; CRC cis rs9914988 0.943 rs4795457 chr17:27087929 C/T cg20469991 chr17:27169893 C17orf63 -0.6 -7.1 -0.36 7.88e-12 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs1862618 0.853 rs1833896 chr5:56097669 C/A cg12311346 chr5:56204834 C5orf35 -0.73 -9.48 -0.46 5.09e-19 Initial pursuit acceleration; CRC trans rs2303319 0.504 rs62187653 chr2:162469128 T/C cg12500891 chr11:57225987 NA -0.67 -6.03 -0.32 4.43e-9 Cognitive function; CRC cis rs1799949 1.000 rs11657835 chr17:41291953 C/G cg01879757 chr17:41196368 BRCA1 -0.42 -6.24 -0.33 1.31e-9 Menopause (age at onset); CRC cis rs11031096 0.782 rs4910888 chr11:4152915 G/A cg18678763 chr11:4115507 RRM1 -0.44 -7.59 -0.39 3.33e-13 Mean corpuscular volume;Mean corpuscular hemoglobin; CRC cis rs1552244 0.554 rs2272122 chr3:10047975 C/G cg16606324 chr3:10149918 C3orf24 0.48 6.93 0.36 2.29e-11 Alzheimer's disease; CRC cis rs10979 0.931 rs9484770 chr6:143896758 A/G cg25407410 chr6:143891975 LOC285740 -0.84 -13.71 -0.6 3.9e-34 Hypospadias; CRC cis rs1499614 0.522 rs13247442 chr7:66188858 T/C cg18252515 chr7:66147081 NA -1.11 -9.85 -0.48 3.19e-20 Gout; CRC cis rs13191362 0.935 rs13215748 chr6:163010710 A/C cg06582575 chr6:163149167 PACRG;PARK2 0.75 10.24 0.49 1.58e-21 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs7772486 0.686 rs9403739 chr6:146015357 A/G cg05347473 chr6:146136440 FBXO30 -0.38 -5.78 -0.3 1.69e-8 Lobe attachment (rater-scored or self-reported); CRC cis rs7589342 0.899 rs10185551 chr2:106492201 A/C cg16077055 chr2:106428750 NCK2 0.41 5.97 0.31 5.98e-9 Addiction; CRC cis rs9322193 0.923 rs62439842 chr6:149996983 G/A cg00933542 chr6:150070202 PCMT1 0.28 5.77 0.3 1.85e-8 Lung cancer; CRC cis rs2777491 0.957 rs16971798 chr15:41657144 A/T cg18705301 chr15:41695430 NDUFAF1 0.63 10.33 0.49 7.51e-22 Ulcerative colitis; CRC cis rs924607 0.931 rs1709556 chr5:637058 A/G cg04476341 chr5:669733 TPPP 0.42 6.88 0.35 3.1e-11 Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia; CRC cis rs78456975 0.527 rs7590743 chr2:1575048 A/G cg12573674 chr2:1569213 NA -0.78 -10.48 -0.5 2.37e-22 Placebo response in major depressive disorder (% change in symptom score); CRC cis rs3750082 0.889 rs11766608 chr7:32940086 C/T cg05721444 chr7:32995514 FKBP9 0.48 7.22 0.37 3.62e-12 Glomerular filtration rate (creatinine); CRC cis rs9443645 0.901 rs9352675 chr6:79612800 G/A cg05283184 chr6:79620031 NA -0.58 -9.34 -0.46 1.48e-18 Intelligence (multi-trait analysis); CRC cis rs17376456 0.569 rs17083377 chr5:93164870 C/G cg21475434 chr5:93447410 FAM172A 0.46 5.9 0.31 9.03e-9 Diabetic retinopathy; CRC cis rs950169 1.000 rs35297609 chr15:84772896 A/G cg17507749 chr15:85114479 UBE2QP1 0.77 11.96 0.55 1.27e-27 Schizophrenia; CRC cis rs7959452 0.868 rs10878967 chr12:69740869 T/C cg14784868 chr12:69753453 YEATS4 0.66 10.22 0.49 1.78e-21 Blood protein levels; CRC trans rs10944 0.598 rs9293761 chr5:78290215 C/T cg10777881 chr1:144044138 NA 0.45 6.32 0.33 8.37e-10 Blood and toenail selenium levels; CRC cis rs7953249 0.514 rs1169312 chr12:121441461 G/T cg02403541 chr12:121454288 C12orf43 0.42 6.27 0.33 1.15e-9 Invasive epithelial ovarian cancer;High-grade serous ovarian cancer;Chronic obstructive pulmonary disease-related biomarkers;N-glycan levels;Serous invasive ovarian cancer;Epithelial ovarian cancer; CRC cis rs13108904 0.870 rs13124876 chr4:1247955 T/C cg02018176 chr4:1364513 KIAA1530 0.45 7.59 0.39 3.43e-13 Obesity-related traits; CRC cis rs7727544 0.507 rs9791170 chr5:131569627 A/G cg18758796 chr5:131593413 PDLIM4 0.46 8.26 0.41 3.59e-15 Blood metabolite levels; CRC cis rs1552244 0.882 rs13064570 chr3:9997545 G/C cg18598329 chr3:10140678 FANCD2;C3orf24 -0.79 -10.46 -0.5 2.78e-22 Alzheimer's disease; CRC cis rs1451375 0.785 rs6593010 chr7:50629888 A/G cg18232548 chr7:50535776 DDC 0.49 6.86 0.35 3.4e-11 Malaria; CRC cis rs79349575 0.783 rs832410 chr17:46972865 C/T cg00947319 chr17:47005597 UBE2Z -0.34 -5.94 -0.31 7.21e-9 Type 2 diabetes; CRC trans rs1814175 0.645 rs28538913 chr11:50040718 C/T cg15704280 chr7:45808275 SEPT13 -0.93 -17.08 -0.69 2.88e-47 Height; CRC cis rs3736485 0.934 rs4775952 chr15:51869056 T/C cg08986416 chr15:51914746 DMXL2 -0.45 -6.64 -0.34 1.3e-10 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs10256972 0.552 rs2960837 chr7:1203957 A/G cg27094323 chr7:1216898 NA -0.35 -5.78 -0.3 1.77e-8 Longevity;Endometriosis; CRC cis rs2153535 0.580 rs965706 chr6:8464708 G/A cg07606381 chr6:8435919 SLC35B3 0.68 10.9 0.51 8.26e-24 Motion sickness; CRC cis rs6089584 0.850 rs6142938 chr20:60627723 A/C cg23463467 chr20:60627584 TAF4 0.36 6.39 0.33 5.67e-10 Body mass index; CRC cis rs1799949 0.965 rs4793234 chr17:41436183 A/G cg19454999 chr17:41278357 BRCA1;NBR2 0.51 7.87 0.4 5.26e-14 Menopause (age at onset); CRC cis rs57994353 0.897 rs36101132 chr9:139367566 G/A cg13611204 chr9:139324423 INPP5E -0.4 -5.7 -0.3 2.73e-8 Eosinophil counts;Cutaneous squamous cell carcinoma; CRC cis rs3087591 0.639 rs1048317 chr17:29704002 T/C cg24425628 chr17:29625626 OMG;NF1 0.64 10.9 0.52 8.01e-24 Hip circumference; CRC cis rs7799006 0.527 rs2159045 chr7:2207401 T/C cg02951883 chr7:2050386 MAD1L1 -0.58 -8.43 -0.42 1.13e-15 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs11758351 0.660 rs16891446 chr6:26226996 A/C cg22723502 chr6:26240528 HIST1H4F -0.36 -5.85 -0.31 1.17e-8 Gout;Renal underexcretion gout; CRC cis rs4820539 1.000 rs916584 chr22:23469433 A/G cg14186256 chr22:23484241 RTDR1 0.89 17.25 0.69 6.26e-48 Bone mineral density; CRC cis rs798554 0.679 rs11973498 chr7:2886873 C/A cg19717773 chr7:2847554 GNA12 -0.4 -5.81 -0.3 1.51e-8 Height; CRC cis rs875971 0.862 rs11769079 chr7:65842128 G/A cg18252515 chr7:66147081 NA -0.41 -5.94 -0.31 7.15e-9 Aortic root size; CRC cis rs9796 0.621 rs9972349 chr15:41491656 A/G cg18705301 chr15:41695430 NDUFAF1 -0.42 -6.92 -0.36 2.38e-11 Menopause (age at onset); CRC cis rs28386778 0.897 rs2665831 chr17:61912392 C/T cg25654072 chr17:61904446 PSMC5;FTSJ3 0.75 11.59 0.54 2.88e-26 Prudent dietary pattern; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg15884411 chr2:96932403 CIAO1;TMEM127 0.42 6.14 0.32 2.32e-9 Intelligence (multi-trait analysis); CRC cis rs9322193 0.923 rs9767123 chr6:149981459 A/G cg13206674 chr6:150067644 NUP43 0.65 9.75 0.47 6.68e-20 Lung cancer; CRC cis rs6921919 0.583 rs6922374 chr6:28381272 T/C cg21251018 chr6:28226885 NKAPL 0.39 5.93 0.31 7.61e-9 Autism spectrum disorder or schizophrenia; CRC trans rs3733585 0.673 rs4560411 chr4:9953361 A/G cg26043149 chr18:55253948 FECH -0.5 -7.71 -0.39 1.51e-13 Cleft plate (environmental tobacco smoke interaction); CRC cis rs870825 0.616 rs6552807 chr4:185640531 A/G cg04058563 chr4:185651563 MLF1IP 0.74 9.66 0.47 1.33e-19 Blood protein levels; CRC cis rs7264396 0.790 rs6058293 chr20:34248891 T/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.61 -10.31 -0.49 8.99e-22 Total cholesterol levels; CRC cis rs12995491 0.763 rs1914735 chr2:88511953 A/T cg04511125 chr2:88470314 THNSL2 -0.4 -5.89 -0.31 9.65e-9 Response to metformin (IC50); CRC cis rs7216064 1.000 rs3935969 chr17:65881959 A/G cg12091567 chr17:66097778 LOC651250 -0.61 -7.68 -0.39 1.84e-13 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CRC cis rs739496 0.542 rs7316698 chr12:111790511 C/T cg10833066 chr12:111807467 FAM109A 0.56 7.25 0.37 3.06e-12 Platelet count; CRC cis rs7618915 0.570 rs11130312 chr3:52675055 A/C cg18404041 chr3:52824283 ITIH1 -0.43 -8.82 -0.44 7.03e-17 Bipolar disorder; CRC cis rs2302190 0.882 rs7210714 chr17:56675666 A/C cg25885038 chr17:56607967 SEPT4 -0.5 -7.55 -0.38 4.26e-13 Vitamin D levels; CRC cis rs9660992 0.573 rs12140422 chr1:205187981 G/A cg00857998 chr1:205179979 DSTYK 0.44 5.82 0.31 1.37e-8 Mean corpuscular volume;Mean platelet volume; CRC cis rs9322193 0.847 rs9383844 chr6:150037404 T/C cg04369109 chr6:150039330 LATS1 -0.41 -5.74 -0.3 2.18e-8 Lung cancer; CRC cis rs11785400 0.731 rs4736363 chr8:143742112 C/A cg10596483 chr8:143751796 JRK 0.47 6.49 0.34 3.11e-10 Schizophrenia; CRC cis rs6547741 0.935 rs6547738 chr2:27852637 A/G cg22903471 chr2:27725779 GCKR 0.35 5.63 0.3 3.83e-8 Oral cavity cancer; CRC trans rs1814175 0.935 rs7479914 chr11:49661351 T/C cg11707556 chr5:10655725 ANKRD33B -0.43 -7.91 -0.4 3.96e-14 Height; CRC trans rs783540 0.500 rs783541 chr15:83255061 T/C cg18393722 chr15:85113863 UBE2QP1 -0.46 -6.56 -0.34 2.1e-10 Schizophrenia; CRC cis rs9640161 0.702 rs3735175 chr7:150020457 C/T cg13722127 chr7:150037890 RARRES2 0.49 7.66 0.39 2.06e-13 Blood protein levels;Circulating chemerin levels; CRC cis rs12477438 0.539 rs720228 chr2:99704547 A/G cg14399236 chr2:99771627 LIPT1;TSGA10 0.83 14.6 0.63 1.5e-37 Chronic sinus infection; CRC cis rs72772090 0.539 rs55996659 chr5:96114150 A/G cg17330273 chr5:96107758 CAST;ERAP1 -0.66 -6.18 -0.32 1.86e-9 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs28386778 0.897 rs2584627 chr17:61901439 T/C cg11494091 chr17:61959527 GH2 0.63 10.64 0.51 6.32e-23 Prudent dietary pattern; CRC cis rs4409675 0.576 rs1474908 chr1:28213213 C/T cg23691781 chr1:28212827 C1orf38 -0.3 -6.58 -0.34 1.83e-10 Corneal astigmatism; CRC cis rs35883536 0.647 rs10493929 chr1:101043928 A/C cg06223162 chr1:101003688 GPR88 -0.36 -6.59 -0.34 1.7e-10 Monocyte count; CRC cis rs7727544 0.645 rs272857 chr5:131685297 G/A cg07395648 chr5:131743802 NA -0.42 -6.5 -0.34 3.05e-10 Blood metabolite levels; CRC cis rs7959452 0.590 rs6581889 chr12:69757429 T/C cg14784868 chr12:69753453 YEATS4 0.85 15.01 0.64 3.63e-39 Blood protein levels; CRC trans rs877282 0.947 rs7475589 chr10:767479 C/G cg22713356 chr15:30763199 NA 1.33 16.07 0.66 2.6e-43 Uric acid levels; CRC cis rs6840360 0.571 rs2165789 chr4:152510130 A/T cg09659197 chr4:152720779 NA 0.31 5.69 0.3 2.77e-8 Intelligence (multi-trait analysis); CRC cis rs9916302 0.851 rs12936646 chr17:37647450 A/T cg00129232 chr17:37814104 STARD3 -0.56 -8.24 -0.41 4.25e-15 Glomerular filtration rate (creatinine); CRC cis rs477692 0.905 rs514963 chr10:131419707 C/T cg05714579 chr10:131428358 MGMT 0.57 8.32 0.42 2.45e-15 Response to temozolomide; CRC cis rs62432291 0.681 rs450538 chr6:159659523 A/G cg14500486 chr6:159655392 FNDC1 -0.77 -10.43 -0.5 3.48e-22 Joint mobility (Beighton score); CRC cis rs9894429 1.000 rs11651264 chr17:79576394 A/G cg21028142 chr17:79581711 NPLOC4 -0.39 -8.62 -0.43 2.89e-16 Eye color traits; CRC cis rs7811142 0.945 rs6955362 chr7:100056166 C/T cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.99 13.68 0.6 4.96e-34 Platelet count; CRC cis rs9900062 0.586 rs6504250 chr17:62680553 T/C cg02598441 chr17:62777298 LOC146880 -0.52 -6.7 -0.35 8.99e-11 QT interval; CRC cis rs3823572 0.564 rs2971953 chr7:133663576 C/T cg03336402 chr7:133662267 EXOC4 -0.66 -10.4 -0.5 4.2e-22 Intelligence (multi-trait analysis); CRC cis rs28386778 0.769 rs6504179 chr17:61812995 T/G cg25654072 chr17:61904446 PSMC5;FTSJ3 0.64 9.52 0.46 4e-19 Prudent dietary pattern; CRC cis rs877282 0.898 rs34490091 chr10:765800 A/C cg06581033 chr10:766294 NA -0.53 -5.79 -0.3 1.61e-8 Uric acid levels; CRC cis rs9929218 0.581 rs12185157 chr16:68784587 G/A cg01251360 chr16:68772225 CDH1 -0.25 -6.15 -0.32 2.28e-9 Colorectal cancer; CRC cis rs875971 0.660 rs2013222 chr7:66035936 C/G cg00343986 chr7:65444356 GUSB -0.47 -7.02 -0.36 1.28e-11 Aortic root size; CRC cis rs55702914 0.742 rs6744206 chr2:198148522 A/G cg20885578 chr2:198174922 NA -0.35 -6.0 -0.31 5.07e-9 Major depression and alcohol dependence; CRC cis rs2239547 0.603 rs6805298 chr3:53096552 A/G cg11645453 chr3:52864694 ITIH4 -0.51 -8.67 -0.43 1.98e-16 Schizophrenia; CRC cis rs10540 1.000 rs116876680 chr11:517473 G/T cg15790184 chr11:494944 RNH1 0.61 6.25 0.33 1.27e-9 Body mass index; CRC cis rs10504229 0.728 rs72650867 chr8:58154912 C/T cg05313129 chr8:58192883 C8orf71 -0.47 -6.18 -0.32 1.94e-9 Developmental language disorder (linguistic errors); CRC cis rs4665809 1.000 rs1470097 chr2:26312840 A/G cg04944784 chr2:26401820 FAM59B -0.6 -7.92 -0.4 3.73e-14 Gut microbiome composition (summer); CRC cis rs7726839 0.574 rs72707007 chr5:661856 T/C cg16447950 chr5:562315 NA -0.78 -10.31 -0.49 9.11e-22 Obesity-related traits; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg19199142 chr21:30671683 BACH1 0.46 6.25 0.33 1.3e-9 Anxiety disorder; CRC cis rs1997103 1.000 rs10278894 chr7:55404748 A/G cg17469321 chr7:55412551 NA 0.72 11.24 0.53 5.04e-25 QRS interval (sulfonylurea treatment interaction); CRC cis rs614226 0.935 rs588132 chr12:121024066 A/G cg27489772 chr12:121021490 NA 0.49 6.48 0.34 3.28e-10 Type 1 diabetes nephropathy; CRC cis rs17270561 0.609 rs1937127 chr6:25769872 G/T cg17691542 chr6:26056736 HIST1H1C -0.67 -8.57 -0.43 4.16e-16 Iron status biomarkers; CRC cis rs35110281 0.667 rs2838354 chr21:45119857 T/C cg04455712 chr21:45112962 RRP1B 0.41 7.64 0.39 2.36e-13 Mean corpuscular volume; CRC cis rs1728785 1.000 rs1728792 chr16:68596534 G/C cg02972257 chr16:68554789 NA -0.6 -7.54 -0.38 4.71e-13 Ulcerative colitis; CRC cis rs4555082 0.874 rs2816611 chr14:105722976 G/C cg06808227 chr14:105710500 BRF1 -0.63 -9.18 -0.45 5.04e-18 Mean platelet volume;Platelet distribution width; CRC cis rs4743820 0.620 rs7046632 chr9:93919341 C/T cg14446406 chr9:93919335 NA 0.81 15.07 0.64 2.19e-39 Ulcerative colitis;Inflammatory bowel disease; CRC cis rs10504229 1.000 rs1961778 chr8:58168756 G/A cg24829409 chr8:58192753 C8orf71 -0.65 -11.09 -0.52 1.74e-24 Developmental language disorder (linguistic errors); CRC cis rs870825 0.616 rs28497285 chr4:185629169 G/A cg04058563 chr4:185651563 MLF1IP 0.72 9.38 0.46 1.12e-18 Blood protein levels; CRC trans rs2231884 0.697 rs11227332 chr11:65623739 A/G cg17712092 chr4:129076599 LARP1B 0.66 7.21 0.37 3.93e-12 Inflammatory bowel disease; CRC cis rs6502050 0.769 rs8068708 chr17:80120424 T/C cg22110888 chr17:80059540 CCDC57 0.4 6.31 0.33 9.05e-10 Life satisfaction; CRC cis rs7487075 0.808 rs10880961 chr12:46765228 C/G cg22049899 chr12:47219821 SLC38A4 0.34 6.32 0.33 8.41e-10 Itch intensity from mosquito bite; CRC cis rs7173389 0.530 rs11636535 chr15:73681648 T/C cg01796676 chr15:73680284 NA 0.53 8.18 0.41 6.23e-15 Resting heart rate; CRC cis rs208520 1.000 rs12199876 chr6:66989469 A/G cg07460842 chr6:66804631 NA 0.92 11.17 0.52 9.12e-25 Exhaled nitric oxide output; CRC cis rs1953600 0.645 rs2819945 chr10:81952956 G/A cg27417294 chr10:81904244 PLAC9 -0.37 -5.82 -0.31 1.38e-8 Sarcoidosis; CRC cis rs2019137 0.936 rs12612729 chr2:113957048 G/A cg11763394 chr2:113992921 PAX8;LOC440839;LOC654433 -0.5 -7.08 -0.36 8.77e-12 Lymphocyte counts; CRC cis rs2836974 0.965 rs8131126 chr21:40655754 A/G cg11890956 chr21:40555474 PSMG1 1.03 16.43 0.67 1.02e-44 Cognitive function; CRC cis rs11031096 0.678 rs4606468 chr11:4183643 G/T cg18678763 chr11:4115507 RRM1 -0.36 -5.82 -0.31 1.37e-8 Mean corpuscular volume;Mean corpuscular hemoglobin; CRC cis rs9925964 0.869 rs2288004 chr16:31054040 G/C cg02466173 chr16:30829666 NA 0.42 5.82 0.31 1.39e-8 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs17376456 0.877 rs12716456 chr5:93397557 A/G cg25358565 chr5:93447407 FAM172A 0.99 10.61 0.5 8.17e-23 Diabetic retinopathy; CRC cis rs1843834 0.898 rs12623277 chr2:225548072 T/G cg22455342 chr2:225449267 CUL3 0.43 5.86 0.31 1.11e-8 IgE levels in asthmatics (D.p. specific); CRC cis rs2251381 0.808 rs7364112 chr21:30548968 C/A cg24692254 chr21:30365293 RNF160 0.76 12.37 0.56 3.97e-29 Selective IgA deficiency; CRC cis rs11212617 0.901 rs4754301 chr11:108048541 G/A cg01991180 chr11:108092276 ATM;NPAT 0.42 6.15 0.32 2.21e-9 Response to metformin in type 2 diabetes (glycemic); CRC cis rs11098499 0.754 rs10213267 chr4:120239074 A/G cg24375607 chr4:120327624 NA 0.48 7.64 0.39 2.32e-13 Corneal astigmatism; CRC cis rs9311474 0.597 rs13303 chr3:52558008 T/C cg08365687 chr3:52569147 NT5DC2;LOC440957 0.35 5.81 0.3 1.5e-8 Electroencephalogram traits; CRC cis rs6424115 1.000 rs7519554 chr1:24154566 T/A cg09473613 chr1:24152604 HMGCL -0.36 -6.16 -0.32 2.18e-9 Immature fraction of reticulocytes; CRC cis rs35883536 0.967 rs4908091 chr1:101138171 G/A cg14515779 chr1:101123966 NA -0.39 -7.56 -0.38 4.11e-13 Monocyte count; CRC cis rs651907 0.557 rs13099674 chr3:101489629 G/A cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.63 8.71 0.43 1.53e-16 Colorectal cancer; CRC cis rs7811142 1.000 rs66632384 chr7:100018904 G/A cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.18 17.67 0.7 1.31e-49 Platelet count; CRC cis rs75920871 0.588 rs6589587 chr11:116875338 T/G cg20608306 chr11:116969690 SIK3 -0.32 -5.87 -0.31 1.06e-8 Subjective well-being; CRC cis rs2404602 0.735 rs11857327 chr15:76764263 G/C cg03037974 chr15:76606532 NA -0.52 -7.5 -0.38 5.99e-13 Blood metabolite levels; CRC cis rs7772486 0.754 rs6937661 chr6:146113299 T/C cg23711669 chr6:146136114 FBXO30 -0.77 -13.39 -0.59 6.18e-33 Lobe attachment (rater-scored or self-reported); CRC cis rs2836974 0.526 rs1888488 chr21:40686521 C/T cg22974920 chr21:40686053 BRWD1 -0.42 -5.65 -0.3 3.51e-8 Cognitive function; CRC cis rs2677744 0.626 rs12915155 chr15:91490894 G/T cg23684204 chr15:91497937 RCCD1 0.43 6.51 0.34 2.8e-10 Attention deficit hyperactivity disorder; CRC cis rs6997458 0.742 rs9969643 chr8:86365987 C/T cg21346043 chr8:86351067 CA3 -0.26 -5.72 -0.3 2.37e-8 Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; CRC cis rs3806843 0.868 rs2563291 chr5:140119599 T/A cg19875535 chr5:140030758 IK -0.56 -9.16 -0.45 5.83e-18 Depressive symptoms (multi-trait analysis); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg13837552 chr12:112819996 NA 0.39 6.39 0.33 5.63e-10 Liver disease severity in Alagille syndrome; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg02420406 chr7:7606596 MIOS 0.48 6.63 0.34 1.37e-10 Response to antipsychotic treatment; CRC cis rs10045504 0.502 rs72746031 chr5:38743161 G/A cg15396434 chr5:38725168 NA -0.6 -6.01 -0.31 4.86e-9 Night sleep phenotypes; CRC cis rs4604732 0.631 rs56704806 chr1:247626148 T/C cg12754571 chr1:247694271 LOC148824;OR2C3 0.41 5.75 0.3 2.04e-8 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CRC cis rs9487051 0.676 rs6568568 chr6:109597048 C/T cg21918786 chr6:109611834 NA -0.41 -7.17 -0.37 4.84e-12 Reticulocyte fraction of red cells; CRC cis rs7552404 0.731 rs6699682 chr1:76340123 A/G cg22875332 chr1:76189707 ACADM -0.57 -7.16 -0.37 5.24e-12 Blood metabolite levels;Acylcarnitine levels; CRC cis rs1008375 0.931 rs10019482 chr4:17578079 G/A cg16339924 chr4:17578868 LAP3 0.6 7.97 0.4 2.6e-14 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs12681288 0.792 rs12678495 chr8:1000858 C/G cg15309053 chr8:964076 NA 0.4 7.37 0.38 1.39e-12 Schizophrenia; CRC cis rs3823572 0.586 rs2001282 chr7:133663287 A/G cg03336402 chr7:133662267 EXOC4 -0.66 -10.4 -0.5 4.2e-22 Intelligence (multi-trait analysis); CRC trans rs561341 0.941 rs7215147 chr17:30266711 G/A cg27661571 chr11:113659931 NA -0.62 -8.16 -0.41 7.01e-15 Hip circumference adjusted for BMI; CRC cis rs6951245 0.554 rs58210047 chr7:1149381 G/A cg03188948 chr7:1209495 NA 0.55 6.46 0.34 3.79e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs7224685 0.501 rs7222628 chr17:3890429 A/G cg21851534 chr17:3907994 ZZEF1 0.36 6.07 0.32 3.57e-9 Type 2 diabetes; CRC cis rs3825932 0.778 rs11072817 chr15:79236815 G/A cg25744700 chr15:79237217 CTSH 0.38 5.71 0.3 2.5e-8 Type 1 diabetes; CRC cis rs853679 0.769 rs7752448 chr6:28301099 A/G cg12172441 chr6:28176163 NA 0.64 5.99 0.31 5.4e-9 Depression; CRC cis rs294883 0.827 rs294906 chr6:159670303 G/A cg14500486 chr6:159655392 FNDC1 -0.39 -6.5 -0.34 2.91e-10 Coronary artery disease; CRC cis rs4731207 0.596 rs7782410 chr7:124571104 A/G cg23710748 chr7:124431027 NA -0.4 -6.25 -0.33 1.28e-9 Cutaneous malignant melanoma; CRC cis rs4713118 0.824 rs9366702 chr6:27734470 T/C cg03623178 chr6:28175578 NA 0.7 9.29 0.46 2.21e-18 Parkinson's disease; CRC cis rs2032447 0.507 rs199741 chr6:25931577 A/G cg18357526 chr6:26021779 HIST1H4A 0.62 7.98 0.4 2.51e-14 Intelligence (multi-trait analysis); CRC cis rs13108904 0.967 rs900029 chr4:1279145 C/T cg21620606 chr4:1342894 KIAA1530 0.34 5.7 0.3 2.7e-8 Obesity-related traits; CRC cis rs1150668 0.699 rs12214383 chr6:28223731 T/C cg15845792 chr6:28175446 NA -0.49 -7.24 -0.37 3.14e-12 Pubertal anthropometrics; CRC cis rs1150668 0.699 rs1531681 chr6:28226878 A/G cg06470822 chr6:28175283 NA 0.54 8.11 0.41 1.04e-14 Pubertal anthropometrics; CRC cis rs9549328 0.614 rs35299896 chr13:113617229 G/T cg25790453 chr13:113633590 MCF2L 0.44 7.65 0.39 2.22e-13 Systolic blood pressure; CRC cis rs1218582 0.682 rs12144978 chr1:154850445 G/A cg03351412 chr1:154909251 PMVK 0.5 7.15 0.37 5.68e-12 Prostate cancer; CRC cis rs1552244 0.748 rs113890152 chr3:10085986 A/G cg18598329 chr3:10140678 FANCD2;C3orf24 -0.88 -11.49 -0.54 6.26e-26 Alzheimer's disease; CRC cis rs12325245 0.536 rs71375919 chr16:58547522 C/T cg19824325 chr16:58548873 SETD6 0.92 6.21 0.32 1.62e-9 Schizophrenia; CRC cis rs6460942 1.000 rs7808819 chr7:12297440 C/T cg06484146 chr7:12443880 VWDE -0.71 -7.28 -0.37 2.56e-12 Coronary artery disease; CRC cis rs514406 0.505 rs374662 chr1:53164549 C/A cg24675658 chr1:53192096 ZYG11B -0.69 -10.7 -0.51 4.12e-23 Monocyte count; CRC cis rs734999 0.545 rs4648565 chr1:2570023 A/G cg18854424 chr1:2615690 NA -0.4 -7.38 -0.38 1.29e-12 Ulcerative colitis; CRC cis rs8180040 0.966 rs12486969 chr3:47429003 G/C cg10298567 chr3:47292165 KIF9 0.38 6.11 0.32 2.74e-9 Colorectal cancer; CRC cis rs1023500 0.505 rs134878 chr22:42663874 A/G cg15557168 chr22:42548783 NA -0.36 -6.04 -0.32 4.19e-9 Schizophrenia; CRC cis rs274567 0.501 rs272855 chr5:131687175 C/T cg12564285 chr5:131593104 PDLIM4 0.45 7.37 0.38 1.41e-12 Blood metabolite levels; CRC cis rs1707322 1.000 rs785465 chr1:46522577 G/T cg06784218 chr1:46089804 CCDC17 0.54 9.35 0.46 1.39e-18 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs798554 0.796 rs2158694 chr7:2863443 T/G cg19717773 chr7:2847554 GNA12 -0.49 -7.04 -0.36 1.14e-11 Height; CRC cis rs2880765 0.566 rs17553249 chr15:86006694 A/G cg10818794 chr15:86012489 AKAP13 -0.45 -7.01 -0.36 1.38e-11 Coronary artery disease; CRC cis rs9747201 0.890 rs12946944 chr17:80061748 C/T cg14673194 chr17:80132900 CCDC57 0.46 5.79 0.3 1.67e-8 Peripheral arterial disease (traffic-related air pollution interaction); CRC trans rs2303319 0.504 rs12470743 chr2:162611202 G/A cg09481857 chr22:21368659 P2RX6;MGC16703 -0.65 -6.31 -0.33 9.13e-10 Cognitive function; CRC cis rs7666738 0.830 rs35531558 chr4:98938217 A/G cg17366294 chr4:99064904 C4orf37 0.43 7.32 0.37 1.95e-12 Colonoscopy-negative controls vs population controls; CRC cis rs9462846 0.725 rs6927188 chr6:42912589 C/T cg02353165 chr6:42928485 GNMT -0.67 -8.77 -0.44 9.78e-17 Blood protein levels; CRC cis rs3812762 0.871 rs10734637 chr11:8788225 A/C cg00186954 chr11:8933980 ST5;C11orf17 0.37 6.22 0.32 1.51e-9 Hypospadias; CRC cis rs2976388 0.566 rs2585141 chr8:143806343 G/A cg05569086 chr8:143859399 LYNX1 -0.43 -7.08 -0.36 8.53e-12 Urinary tract infection frequency; CRC cis rs977987 0.902 rs34539062 chr16:75493279 C/A cg03315344 chr16:75512273 CHST6 0.6 10.19 0.49 2.21e-21 Dupuytren's disease; CRC cis rs4713118 0.516 rs4713142 chr6:28106347 T/G cg25164649 chr6:28176230 NA 0.76 9.53 0.46 3.71e-19 Parkinson's disease; CRC cis rs7516138 1.000 rs4240896 chr1:9713500 A/G cg26573321 chr1:9711663 PIK3CD -0.62 -12.6 -0.57 5.43e-30 Monocyte count; CRC cis rs6502050 0.805 rs6502061 chr17:80086158 C/T cg25804541 chr17:80189381 SLC16A3 0.31 6.01 0.31 4.97e-9 Life satisfaction; CRC cis rs7666738 0.830 rs6855393 chr4:99056534 T/C cg05340658 chr4:99064831 C4orf37 0.6 9.31 0.46 1.85e-18 Colonoscopy-negative controls vs population controls; CRC cis rs425277 0.628 rs10797427 chr1:2060732 C/T cg19257562 chr1:2043853 PRKCZ 0.37 6.32 0.33 8.75e-10 Height; CRC cis rs2380220 0.606 rs7747776 chr6:96005852 C/T cg04719120 chr6:96025338 MANEA 0.58 7.78 0.39 9.45e-14 Behavioural disinhibition (generation interaction); CRC cis rs17376456 0.877 rs9314100 chr5:93447394 T/C cg25358565 chr5:93447407 FAM172A 1.02 10.38 0.5 4.9e-22 Diabetic retinopathy; CRC trans rs9784649 1.000 rs56156666 chr5:24999440 A/T cg08600765 chr20:34638493 LOC647979 -0.62 -7.47 -0.38 7.09e-13 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs62064224 0.614 rs728718 chr17:30708960 T/G cg25809561 chr17:30822961 MYO1D 0.51 9.16 0.45 5.77e-18 Schizophrenia; CRC trans rs7821565 0.904 rs73573847 chr8:52166881 G/A cg09187163 chr7:72721838 NSUN5 -0.41 -6.0 -0.31 5.31e-9 Tuberculosis; CRC cis rs1832871 0.521 rs878585 chr6:158815897 C/T cg07165851 chr6:158734300 TULP4 0.46 5.95 0.31 6.95e-9 Height; CRC cis rs10751667 0.600 rs10794342 chr11:924904 C/T cg01483505 chr11:975446 AP2A2 0.42 6.78 0.35 5.69e-11 Alzheimer's disease (late onset); CRC cis rs2404602 0.647 rs3812908 chr15:77176158 C/T cg03037974 chr15:76606532 NA 0.52 7.92 0.4 3.57e-14 Blood metabolite levels; CRC cis rs6540559 1.000 rs2235373 chr1:209963803 G/A cg21951975 chr1:209979733 IRF6 0.48 6.9 0.36 2.76e-11 Cleft lip with or without cleft palate; CRC cis rs7224685 0.501 rs781852 chr17:3953102 A/G cg09695851 chr17:3907499 NA 0.78 14.84 0.63 1.69e-38 Type 2 diabetes; CRC cis rs754466 0.606 rs11002309 chr10:79594931 C/T cg26805224 chr10:79626177 DLG5 -0.5 -7.11 -0.37 7.15e-12 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs938554 0.784 rs13131257 chr4:9981889 T/C cg11266682 chr4:10021025 SLC2A9 0.35 5.65 0.3 3.4e-8 Blood metabolite levels; CRC cis rs4321325 0.733 rs4510165 chr2:127936284 C/T cg11380483 chr2:127933992 NA 0.64 7.76 0.39 1.04e-13 Protein C levels; CRC cis rs6964587 1.000 rs17164275 chr7:91590408 A/G cg17063962 chr7:91808500 NA 0.81 13.86 0.61 9.83e-35 Breast cancer; CRC cis rs1347297 0.666 rs2114581 chr2:179269678 A/G cg03991736 chr2:179345203 MIR548N;PLEKHA3 -0.42 -5.93 -0.31 7.66e-9 Alzheimer disease and age of onset; CRC cis rs4665809 0.590 rs1049987 chr2:26413817 C/T cg26119090 chr2:26468346 HADHA;HADHB 1.04 14.6 0.63 1.38e-37 Gut microbiome composition (summer); CRC trans rs7914735 0.604 rs11194230 chr10:110459019 C/T cg10858369 chr11:6476139 TRIM3 -0.38 -6.0 -0.31 5.31e-9 Iris heterochromicity; CRC cis rs6952808 0.723 rs11766575 chr7:2005747 T/C cg22963979 chr7:1858916 MAD1L1 -0.5 -7.21 -0.37 3.78e-12 Bipolar disorder and schizophrenia; CRC cis rs2742417 0.603 rs2531755 chr3:45772742 T/C cg04837898 chr3:45731254 SACM1L -0.48 -7.69 -0.39 1.74e-13 Response to anti-depressant treatment in major depressive disorder; CRC cis rs9837602 0.935 rs17392948 chr3:99754498 A/G cg07805332 chr3:99536008 MIR548G;C3orf26 -0.48 -6.19 -0.32 1.82e-9 Breast cancer; CRC cis rs651907 0.557 rs17411983 chr3:101399126 A/G cg11279151 chr3:101281821 RG9MTD1 0.57 7.83 0.4 6.55e-14 Colorectal cancer; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg04999270 chr1:14076291 PRDM2 0.46 6.31 0.33 9.23e-10 Response to antipsychotic treatment; CRC cis rs853679 0.517 rs17711344 chr6:28077602 A/G cg02683197 chr6:28174875 NA -0.84 -10.42 -0.5 3.83e-22 Depression; CRC cis rs7216064 1.000 rs8082512 chr17:65837059 T/C cg12091567 chr17:66097778 LOC651250 -0.67 -7.66 -0.39 2.04e-13 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CRC cis rs897984 0.646 rs9938088 chr16:30830004 G/A cg00531865 chr16:30841666 NA -0.5 -7.48 -0.38 6.92e-13 Dementia with Lewy bodies; CRC cis rs791888 0.965 rs791876 chr10:89406527 G/A cg13926569 chr10:89418898 PAPSS2 -0.44 -6.49 -0.34 3.15e-10 Magnesium levels; CRC cis rs1008375 0.966 rs4698619 chr4:17580955 G/A cg02297831 chr4:17616191 MED28 0.44 5.73 0.3 2.27e-8 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs9847710 0.967 rs2564931 chr3:53020559 G/A cg04503182 chr3:53078218 SFMBT1 0.42 6.32 0.33 8.32e-10 Ulcerative colitis; CRC cis rs2050392 0.517 rs593400 chr10:30762088 A/G cg25182066 chr10:30743637 MAP3K8 0.55 7.74 0.39 1.24e-13 Inflammatory bowel disease; CRC cis rs9303542 0.625 rs9905940 chr17:46614102 A/C cg04904318 chr17:46607828 HOXB1 0.45 5.99 0.31 5.42e-9 Ovarian cancer;Epithelial ovarian cancer; CRC cis rs9311474 0.508 rs7625743 chr3:52606366 C/G cg15147215 chr3:52552868 STAB1 -0.63 -10.98 -0.52 4.02e-24 Electroencephalogram traits; CRC cis rs798554 0.757 rs1183085 chr7:2875570 G/A cg19346786 chr7:2764209 NA -0.42 -7.18 -0.37 4.57e-12 Height; CRC cis rs10504229 1.000 rs61998259 chr8:58192290 T/C cg24829409 chr8:58192753 C8orf71 -0.68 -11.34 -0.53 2.27e-25 Developmental language disorder (linguistic errors); CRC cis rs875971 0.862 rs1167399 chr7:65561877 G/A cg00343986 chr7:65444356 GUSB -0.44 -6.31 -0.33 9.16e-10 Aortic root size; CRC trans rs2303319 0.504 rs12467625 chr2:162603387 C/A cg25193742 chr10:104614220 C10orf32 -0.77 -6.51 -0.34 2.87e-10 Cognitive function; CRC cis rs3617 0.503 rs9866243 chr3:52915219 C/T cg07507251 chr3:52567010 NT5DC2 -0.4 -6.24 -0.33 1.36e-9 Red blood cell count;Autism spectrum disorder or schizophrenia; CRC cis rs12142240 0.698 rs6690075 chr1:46819848 G/A cg00530320 chr1:46809349 NSUN4 0.58 7.93 0.4 3.43e-14 Menopause (age at onset); CRC cis rs2243480 0.901 rs73148097 chr7:65431787 A/C cg25985355 chr7:65971099 NA -0.49 -5.85 -0.31 1.19e-8 Diabetic kidney disease; CRC cis rs8072100 0.667 rs1912485 chr17:45515678 T/G cg25173405 chr17:45401733 C17orf57 -0.43 -6.44 -0.33 4.13e-10 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs4927850 1.000 rs7630875 chr3:195753766 A/G cg12923728 chr3:195709715 SDHAP1 -0.7 -10.88 -0.51 9.29e-24 Pancreatic cancer; CRC cis rs3099143 0.908 rs3102716 chr15:77051003 T/G cg21673338 chr15:77095150 SCAPER -0.76 -8.02 -0.4 1.83e-14 Recalcitrant atopic dermatitis; CRC cis rs10504229 0.953 rs66509078 chr8:58174734 G/C cg05313129 chr8:58192883 C8orf71 -0.47 -6.99 -0.36 1.49e-11 Developmental language disorder (linguistic errors); CRC cis rs375066 0.592 rs349047 chr19:44300884 G/A cg11993925 chr19:44307056 LYPD5 -0.38 -6.18 -0.32 1.9e-9 Breast cancer; CRC cis rs672059 1.000 rs559476 chr1:183160704 T/C ch.1.3577855R chr1:183094577 LAMC1 0.5 7.28 0.37 2.41e-12 Hypertriglyceridemia; CRC cis rs9807989 0.839 rs4988957 chr2:102968075 C/T cg03938978 chr2:103052716 IL18RAP -0.36 -5.79 -0.3 1.66e-8 Asthma; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg02285715 chr20:61493179 TCFL5 0.43 6.03 0.32 4.29e-9 Anxiety disorder; CRC cis rs4563143 0.647 rs117946634 chr19:29256822 G/T cg14983838 chr19:29218262 NA 0.47 6.82 0.35 4.42e-11 Methadone dose in opioid dependence; CRC cis rs4731207 0.596 rs10274384 chr7:124650437 T/A cg23710748 chr7:124431027 NA -0.39 -6.24 -0.33 1.36e-9 Cutaneous malignant melanoma; CRC cis rs4731207 0.698 rs10245872 chr7:124535253 A/T cg23710748 chr7:124431027 NA -0.38 -6.06 -0.32 3.65e-9 Cutaneous malignant melanoma; CRC cis rs7208859 0.673 rs28588622 chr17:29245699 G/A cg01831904 chr17:28903510 LRRC37B2 -0.56 -6.02 -0.32 4.64e-9 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs1865760 1.000 rs3830057 chr6:25918510 G/T cg17691542 chr6:26056736 HIST1H1C 0.56 8.43 0.42 1.08e-15 Height; CRC cis rs812925 0.515 rs1177308 chr2:61387254 C/G cg10580144 chr2:61372316 C2orf74 0.36 8.04 0.41 1.61e-14 Immature fraction of reticulocytes; CRC cis rs4862750 0.874 rs6553027 chr4:187875777 T/C cg07414643 chr4:187882934 NA 0.38 6.49 0.34 3.19e-10 Lobe attachment (rater-scored or self-reported); CRC cis rs6952808 0.582 rs871925 chr7:2047875 G/A cg00106254 chr7:1943704 MAD1L1 0.41 6.28 0.33 1.08e-9 Bipolar disorder and schizophrenia; CRC cis rs9914988 0.778 rs9907185 chr17:27122414 C/T cg07195577 chr17:27052828 TLCD1 0.42 6.02 0.32 4.64e-9 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs9381040 0.655 rs6903444 chr6:41014220 C/T cg09580153 chr6:41068724 NFYA;LOC221442 0.43 6.09 0.32 3.14e-9 Alzheimer's disease (late onset); CRC cis rs6460942 1.000 rs75564554 chr7:12319362 A/C cg20607287 chr7:12443886 VWDE -0.65 -6.43 -0.33 4.61e-10 Coronary artery disease; CRC cis rs6459804 1.000 rs6459806 chr7:157510483 C/G cg05585630 chr7:157510462 PTPRN2 -0.41 -6.53 -0.34 2.49e-10 Bipolar disorder and schizophrenia; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg17164693 chr10:124913828 BUB3 0.42 6.01 0.31 4.92e-9 Response to antipsychotic treatment; CRC cis rs4819052 0.851 rs10470247 chr21:46659018 T/C cg11663144 chr21:46675770 NA -0.8 -13.38 -0.59 6.77e-33 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs2839186 0.526 rs2839297 chr21:47921839 A/G cg13126279 chr21:47581558 C21orf56 -0.38 -5.88 -0.31 9.83e-9 Testicular germ cell tumor; CRC cis rs7786808 0.544 rs6971888 chr7:158193835 G/A cg15440763 chr7:158190612 PTPRN2 -0.39 -6.37 -0.33 6.52e-10 Obesity-related traits; CRC cis rs7826238 0.535 rs2979179 chr8:8320029 C/T cg06636001 chr8:8085503 FLJ10661 0.57 9.13 0.45 7.25e-18 Systolic blood pressure; CRC cis rs1757171 0.534 rs2797793 chr6:37477262 C/T cg25019722 chr6:37503610 NA 0.39 6.43 0.33 4.62e-10 Cognitive performance; CRC cis rs11123170 0.529 rs1015753 chr2:113968803 T/G cg21550016 chr2:113992930 PAX8;LOC440839;LOC654433 0.52 6.15 0.32 2.22e-9 Renal function-related traits (BUN); CRC cis rs9916302 0.904 rs4795356 chr17:37535631 C/T cg15445000 chr17:37608096 MED1 -0.44 -9.71 -0.47 9.39e-20 Glomerular filtration rate (creatinine); CRC trans rs41997 0.785 rs2110215 chr7:118071216 C/T cg21587861 chr12:32260103 BICD1 -0.57 -6.01 -0.31 4.94e-9 Response to platinum-based chemotherapy in non-small-cell lung cancer; CRC cis rs4713118 0.868 rs9468220 chr6:27732976 A/G cg02683197 chr6:28174875 NA -0.64 -6.82 -0.35 4.46e-11 Parkinson's disease; CRC cis rs684232 0.602 rs2160955 chr17:560604 T/C cg15660573 chr17:549704 VPS53 -0.87 -15.84 -0.66 2.22e-42 Prostate cancer; CRC trans rs2797160 1.000 rs2747714 chr6:126007620 A/G cg05039488 chr6:79577232 IRAK1BP1 0.49 7.3 0.37 2.11e-12 Endometrial cancer; CRC cis rs853679 0.546 rs200948 chr6:27835272 T/C cg19041857 chr6:27730383 NA -0.71 -6.71 -0.35 8.65e-11 Depression; CRC cis rs10028773 0.666 rs35231872 chr4:120248376 A/T cg24375607 chr4:120327624 NA 0.46 7.05 0.36 1.03e-11 Educational attainment; CRC cis rs11734570 0.581 rs76682731 chr4:38586045 T/C cg18361445 chr4:38666374 KLF3;FLJ13197 0.54 6.82 0.35 4.27e-11 Inflammatory bowel disease;Crohn's disease; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg06406294 chr21:34915161 GART;SON 0.41 6.68 0.35 1.04e-10 Liver disease severity in Alagille syndrome; CRC cis rs1707322 0.963 rs9787412 chr1:46371596 C/T cg06784218 chr1:46089804 CCDC17 0.52 9.12 0.45 7.88e-18 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC trans rs8002861 0.935 rs1811464 chr13:44469290 T/G cg17145862 chr1:211918768 LPGAT1 0.78 15.87 0.66 1.66e-42 Leprosy; CRC cis rs10504229 0.683 rs56235637 chr8:58106008 T/C cg21724239 chr8:58056113 NA 0.52 6.99 0.36 1.58e-11 Developmental language disorder (linguistic errors); CRC cis rs477692 0.571 rs10764890 chr10:131347163 G/A cg24747557 chr10:131355152 MGMT -0.41 -5.85 -0.31 1.16e-8 Response to temozolomide; CRC cis rs7216064 1.000 rs7208663 chr17:65885171 T/C cg12091567 chr17:66097778 LOC651250 -0.62 -7.88 -0.4 4.78e-14 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CRC cis rs875971 1.000 rs6957199 chr7:65978519 T/C cg18912574 chr7:65842487 NCRNA00174 0.35 6.08 0.32 3.34e-9 Aortic root size; CRC cis rs12681288 0.823 rs2701906 chr8:1003316 T/C cg04851639 chr8:1020857 NA -0.35 -7.33 -0.37 1.79e-12 Schizophrenia; CRC cis rs3087591 0.960 rs2905797 chr17:29537458 G/C cg24425628 chr17:29625626 OMG;NF1 0.82 14.5 0.62 3.4e-37 Hip circumference; CRC cis rs4478858 0.735 rs10914368 chr1:31847937 A/G cg00250761 chr1:31883323 NA -0.41 -7.64 -0.39 2.33e-13 Alcohol dependence; CRC cis rs4713118 0.869 rs9461400 chr6:27700559 A/G cg25164649 chr6:28176230 NA 0.58 8.19 0.41 5.97e-15 Parkinson's disease; CRC cis rs12142240 0.659 rs17361873 chr1:46832686 A/G cg00530320 chr1:46809349 NSUN4 0.59 8.11 0.41 1.02e-14 Menopause (age at onset); CRC cis rs2354432 0.556 rs2275249 chr1:146759320 C/G cg25205988 chr1:146714368 CHD1L 1.11 9.82 0.48 4.02e-20 Mitochondrial DNA levels; CRC cis rs35110281 0.712 rs167930 chr21:44946625 G/A cg04455712 chr21:45112962 RRP1B 0.41 7.91 0.4 3.93e-14 Mean corpuscular volume; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg08541772 chr1:209958162 C1orf74 0.43 5.97 0.31 6.13e-9 Response to antipsychotic treatment; CRC cis rs12692738 0.526 rs355860 chr2:165629911 T/G cg03182029 chr2:165697222 COBLL1 0.5 5.86 0.31 1.11e-8 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);Waist-to-hip ratio adjusted for BMI in non-smokers;Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction);Waist-to-hip ratio adjusted for body mass index; CRC cis rs12541635 0.677 rs6999580 chr8:107018254 C/T cg10147462 chr8:107024639 NA 0.57 10.13 0.49 3.61e-21 Age of smoking initiation; CRC cis rs896854 0.684 rs10098778 chr8:95992020 C/T cg23172400 chr8:95962367 TP53INP1 -0.48 -8.14 -0.41 8.11e-15 Type 2 diabetes; CRC cis rs1129187 0.755 rs9471988 chr6:42944773 T/C cg03790207 chr6:42947109 PEX6 -0.52 -7.56 -0.38 4e-13 Alzheimer's disease in APOE e4+ carriers; CRC cis rs17376456 0.877 rs12153788 chr5:93405437 A/G cg09848695 chr5:92956644 FAM172A;MIR2277 0.61 5.68 0.3 2.95e-8 Diabetic retinopathy; CRC cis rs523522 0.962 rs655530 chr12:121022275 T/C cg27279351 chr12:120934652 DYNLL1 0.75 10.75 0.51 2.64e-23 High light scatter reticulocyte count; CRC cis rs7552404 0.889 rs380075 chr1:76106961 T/A cg10523679 chr1:76189770 ACADM -0.83 -11.3 -0.53 3.14e-25 Blood metabolite levels;Acylcarnitine levels; CRC cis rs9915657 0.870 rs12941066 chr17:70141226 C/T cg09344028 chr17:70110421 NA 0.45 6.85 0.35 3.58e-11 Thyroid hormone levels; CRC cis rs7811142 0.830 rs11761426 chr7:99956893 A/T cg00814883 chr7:100076585 TSC22D4 -0.7 -8.85 -0.44 5.49e-17 Platelet count; CRC cis rs2777491 0.872 rs7163649 chr15:41586798 A/G cg18705301 chr15:41695430 NDUFAF1 -0.69 -11.4 -0.53 1.31e-25 Ulcerative colitis; CRC cis rs599083 0.530 rs689179 chr11:68179166 A/G cg01657329 chr11:68192670 LRP5 0.49 7.03 0.36 1.18e-11 Bone mineral density (spine); CRC cis rs919433 1.000 rs1346649 chr2:198166117 C/A cg03934865 chr2:198174659 NA -0.44 -7.9 -0.4 4.24e-14 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC cis rs853679 0.550 rs6901017 chr6:28152583 T/C cg12963246 chr6:28129442 ZNF389 0.5 6.09 0.32 3.17e-9 Depression; CRC cis rs10927875 0.691 rs1048261 chr1:16340951 A/T cg10494257 chr1:16342123 HSPB7 0.45 5.91 0.31 8.55e-9 Dilated cardiomyopathy; CRC cis rs911555 0.574 rs34251103 chr14:103860063 A/G cg12935359 chr14:103987150 CKB 0.55 8.72 0.43 1.43e-16 Intelligence (multi-trait analysis); CRC cis rs17376456 0.825 rs6898842 chr5:93213221 T/C cg25358565 chr5:93447407 FAM172A 1.08 10.13 0.49 3.66e-21 Diabetic retinopathy; CRC cis rs12477438 0.520 rs13798 chr2:99813614 T/C cg14399236 chr2:99771627 LIPT1;TSGA10 0.76 13.21 0.59 2.91e-32 Chronic sinus infection; CRC cis rs9733 0.650 rs3738485 chr1:150552392 C/G cg17724175 chr1:150552817 MCL1 -0.51 -8.17 -0.41 6.89e-15 Tonsillectomy; CRC cis rs3849570 0.576 rs4425286 chr3:81992365 G/A cg07356753 chr3:81810745 GBE1 -0.47 -6.41 -0.33 5.15e-10 Waist circumference;Body mass index; CRC cis rs7824557 0.564 rs2572399 chr8:11234520 A/G cg20542592 chr8:11973495 FAM66D 0.32 5.69 0.3 2.76e-8 Retinal vascular caliber; CRC cis rs2739330 0.828 rs5751770 chr22:24252842 A/G cg24846343 chr22:24311635 DDTL 0.84 14.87 0.63 1.26e-38 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs5769765 0.862 rs9616386 chr22:50313179 G/A cg04121214 chr22:50244548 NA 0.42 5.89 0.31 9.4e-9 Schizophrenia; CRC cis rs7312933 0.558 rs11181466 chr12:42765181 A/T cg11827402 chr12:42719852 PPHLN1;ZCRB1 0.68 9.75 0.47 6.81e-20 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CRC trans rs617791 0.508 rs10896074 chr11:65776304 C/T cg17712092 chr4:129076599 LARP1B -0.46 -6.49 -0.34 3.08e-10 Breast cancer; CRC cis rs6662572 0.686 rs72677546 chr1:46577716 C/T cg03123370 chr1:45965343 CCDC163P;MMACHC 0.49 6.4 0.33 5.26e-10 Blood protein levels; CRC cis rs7727544 0.735 rs2569266 chr5:131706791 T/C cg11843238 chr5:131593191 PDLIM4 -0.32 -5.92 -0.31 8.13e-9 Blood metabolite levels; CRC cis rs6743376 0.556 rs957201 chr2:113821200 T/C cg09040174 chr2:113837401 NA 0.4 5.85 0.31 1.18e-8 Inflammatory biomarkers; CRC trans rs9329221 0.772 rs7824675 chr8:10243418 G/T cg08975724 chr8:8085496 FLJ10661 -0.46 -7.25 -0.37 3.05e-12 Neuroticism; CRC cis rs1003719 0.715 rs4261789 chr21:38503762 T/G cg10648535 chr21:38446584 PIGP;TTC3 -0.5 -6.91 -0.36 2.45e-11 Eye color traits; CRC cis rs9322193 0.923 rs1984111 chr6:150152856 G/A cg07701084 chr6:150067640 NUP43 0.46 6.49 0.34 3.22e-10 Lung cancer; CRC cis rs9527 0.637 rs7085104 chr10:104628873 A/G cg04362960 chr10:104952993 NT5C2 0.63 8.79 0.44 8.21e-17 Arsenic metabolism; CRC trans rs7618501 0.633 rs2856234 chr3:50139142 A/G cg21665057 chr3:196295764 WDR53;FBXO45 -0.58 -9.3 -0.46 1.98e-18 Intelligence (multi-trait analysis); CRC cis rs3736485 0.808 rs4462537 chr15:51826518 A/G cg08986416 chr15:51914746 DMXL2 -0.49 -7.06 -0.36 9.93e-12 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs9487051 0.872 rs9480923 chr6:109607369 G/C cg01475377 chr6:109611718 NA -0.49 -9.3 -0.46 1.98e-18 Reticulocyte fraction of red cells; CRC cis rs7605827 0.930 rs11687253 chr2:15655869 A/G cg19274914 chr2:15703543 NA -0.38 -5.81 -0.3 1.51e-8 Educational attainment (years of education); CRC trans rs2243480 1.000 rs160655 chr7:65533214 T/C cg10756647 chr7:56101905 PSPH 0.62 6.56 0.34 2.04e-10 Diabetic kidney disease; CRC trans rs9540294 1.000 rs2175688 chr13:65541333 A/C cg18771126 chr3:119150634 TMEM39A 0.56 6.12 0.32 2.69e-9 Recalcitrant atopic dermatitis; CRC cis rs28386778 0.897 rs2727287 chr17:61904728 G/A cg06873352 chr17:61820015 STRADA 0.77 14.58 0.63 1.65e-37 Prudent dietary pattern; CRC cis rs4713118 0.869 rs9461401 chr6:27703291 G/A cg26587870 chr6:27730563 NA -0.43 -6.72 -0.35 8.04e-11 Parkinson's disease; CRC cis rs9372498 0.536 rs9489433 chr6:118867006 G/A cg22561889 chr6:118971681 C6orf204 0.5 6.52 0.34 2.71e-10 Diastolic blood pressure; CRC cis rs6964587 0.869 rs11769294 chr7:91549937 C/T cg17063962 chr7:91808500 NA 0.75 12.98 0.58 2.25e-31 Breast cancer; CRC trans rs11026407 0.967 rs7127246 chr11:22060228 C/G cg22766770 chr17:18218566 TOP3A;SMCR8 -0.59 -6.14 -0.32 2.35e-9 Plasma thyroid-stimulating hormone levels; CRC cis rs765787 0.530 rs10851423 chr15:45515950 G/A cg24006582 chr15:45444508 DUOX1 0.57 8.28 0.42 3.18e-15 Uric acid levels; CRC trans rs8002861 0.641 rs2325085 chr13:44410060 G/A cg17145862 chr1:211918768 LPGAT1 0.59 10.07 0.49 5.64e-21 Leprosy; CRC cis rs4555082 0.756 rs76863138 chr14:105736379 C/T cg06808227 chr14:105710500 BRF1 -0.61 -8.65 -0.43 2.36e-16 Mean platelet volume;Platelet distribution width; CRC cis rs2075371 0.611 rs11762920 chr7:134018514 C/T cg02659138 chr7:134003124 SLC35B4 0.36 5.74 0.3 2.16e-8 Mean platelet volume; CRC cis rs4713675 0.584 rs560111 chr6:33706277 C/T cg14003231 chr6:33640908 ITPR3 0.36 5.86 0.31 1.11e-8 Plateletcrit; CRC cis rs35110281 0.807 rs2838325 chr21:45014284 A/T cg01579765 chr21:45077557 HSF2BP 0.3 5.69 0.3 2.8e-8 Mean corpuscular volume; CRC cis rs7131987 0.676 rs10843407 chr12:29550244 A/G cg09582351 chr12:29534625 ERGIC2 0.34 7.26 0.37 2.83e-12 QT interval; CRC cis rs17818399 0.612 rs4952834 chr2:46777462 C/G cg06386533 chr2:46925753 SOCS5 0.48 6.45 0.33 4.05e-10 Height; CRC cis rs546131 0.820 rs744841 chr11:34857667 G/A cg11058730 chr11:34937778 PDHX;APIP 0.47 6.75 0.35 6.84e-11 Lung disease severity in cystic fibrosis; CRC cis rs4862750 0.872 rs6821507 chr4:187876829 G/T cg27532560 chr4:187881888 NA 0.55 10.22 0.49 1.75e-21 Lobe attachment (rater-scored or self-reported); CRC cis rs9311676 0.656 rs62258093 chr3:58371745 T/C cg06643156 chr3:58380774 PXK 0.42 6.39 0.33 5.78e-10 Systemic lupus erythematosus; CRC cis rs3791556 0.504 rs1001285 chr2:240107814 A/G cg08444004 chr2:240086178 HDAC4 0.36 5.96 0.31 6.57e-9 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs853679 0.517 rs9380050 chr6:28048538 A/G cg15845792 chr6:28175446 NA 0.97 13.03 0.58 1.43e-31 Depression; CRC cis rs589448 0.933 rs2249093 chr12:69753512 G/C cg14784868 chr12:69753453 YEATS4 0.91 17.35 0.69 2.44e-48 Cerebrospinal fluid biomarker levels; CRC cis rs763014 1.000 rs763014 chr16:675680 T/C cg04562611 chr16:615315 C16orf11 0.38 6.33 0.33 7.96e-10 Height; CRC cis rs11958404 1.000 rs72816531 chr5:157413079 A/G cg05962755 chr5:157440814 NA 0.78 10.75 0.51 2.66e-23 IgG glycosylation; CRC cis rs274567 0.550 rs272885 chr5:131667736 A/G cg20512303 chr5:131592959 PDLIM4 0.39 6.69 0.35 9.86e-11 Blood metabolite levels; CRC trans rs9784649 0.891 rs57355285 chr5:25016384 C/G cg08600765 chr20:34638493 LOC647979 -0.64 -7.73 -0.39 1.36e-13 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs28386778 0.830 rs6504180 chr17:61813169 T/C cg25654072 chr17:61904446 PSMC5;FTSJ3 0.7 10.91 0.52 7.25e-24 Prudent dietary pattern; CRC cis rs12451471 0.559 rs1042396 chr17:78084769 G/A cg08347473 chr17:78092826 GAA -0.37 -6.13 -0.32 2.53e-9 Plateletcrit;Mean corpuscular hemoglobin concentration; CRC cis rs7595037 0.663 rs11126185 chr2:68652580 G/A cg12452813 chr2:68675892 NA -0.44 -6.48 -0.34 3.39e-10 Multiple sclerosis; CRC cis rs2066819 0.786 rs111580405 chr12:56739557 A/G cg26714650 chr12:56694279 CS -1.41 -11.53 -0.54 4.75e-26 Psoriasis vulgaris; CRC cis rs589448 0.902 rs315138 chr12:69764850 A/T cg22834771 chr12:69754056 YEATS4 -0.56 -8.68 -0.43 1.93e-16 Cerebrospinal fluid biomarker levels; CRC cis rs780096 0.526 rs780112 chr2:27665361 C/G cg22903471 chr2:27725779 GCKR -0.37 -5.99 -0.31 5.48e-9 Total body bone mineral density; CRC cis rs7726839 0.540 rs3749618 chr5:602650 A/G cg16447950 chr5:562315 NA -0.74 -9.74 -0.47 7.34e-20 Obesity-related traits; CRC cis rs1448094 0.791 rs10863114 chr12:86332325 T/C cg25456477 chr12:86230367 RASSF9 0.34 5.75 0.3 2.02e-8 Major depressive disorder; CRC cis rs35110281 0.667 rs4819288 chr21:45120173 C/G cg01579765 chr21:45077557 HSF2BP -0.31 -5.62 -0.3 4.03e-8 Mean corpuscular volume; CRC cis rs523522 0.962 rs2233676 chr12:120933607 G/A cg27279351 chr12:120934652 DYNLL1 0.79 11.6 0.54 2.58e-26 High light scatter reticulocyte count; CRC trans rs7580658 0.614 rs7585198 chr2:127962635 C/T cg04558362 chr11:64863611 C11orf2 -0.45 -6.13 -0.32 2.53e-9 Protein C levels; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg19650755 chr12:68617143 IL26 0.41 6.45 0.34 4.04e-10 Liver disease severity in Alagille syndrome; CRC cis rs4731207 0.596 rs900047 chr7:124673373 A/G cg23710748 chr7:124431027 NA 0.38 5.98 0.31 5.71e-9 Cutaneous malignant melanoma; CRC cis rs9560113 0.550 rs1163633 chr13:112231561 G/T cg10483660 chr13:112241077 NA -0.63 -12.4 -0.56 3.06e-29 Menarche (age at onset); CRC cis rs597539 0.690 rs7129960 chr11:68622456 A/G cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.85 13.59 0.6 1.05e-33 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg21005948 chr18:46065258 KIAA0427 0.4 6.41 0.33 5.06e-10 Liver disease severity in Alagille syndrome; CRC cis rs6662572 0.737 rs6693222 chr1:46461178 A/G cg08644498 chr1:46502608 NA 0.46 7.3 0.37 2.19e-12 Blood protein levels; CRC cis rs4819052 0.851 rs4819042 chr21:46660072 A/G cg11663144 chr21:46675770 NA -0.83 -14.12 -0.61 9.88e-36 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC trans rs473651 0.935 rs508483 chr2:239339709 T/C cg13521940 chr21:36262239 RUNX1 -0.41 -6.2 -0.32 1.71e-9 Multiple system atrophy; CRC cis rs883565 0.528 rs4504116 chr3:38953768 A/G cg01426195 chr3:39028469 NA 0.38 6.37 0.33 6.41e-10 Handedness; CRC cis rs2953174 0.786 rs2953145 chr2:241515596 C/G cg07929629 chr2:241523174 NA -0.51 -6.11 -0.32 2.82e-9 Bipolar disorder; CRC cis rs10504229 1.000 rs17216648 chr8:58169429 C/T cg22535103 chr8:58192502 C8orf71 -0.8 -12.19 -0.56 1.9e-28 Developmental language disorder (linguistic errors); CRC cis rs6951245 1.000 rs80031817 chr7:1096793 T/C cg22907277 chr7:1156413 C7orf50 0.72 7.6 0.39 3.1400000000000003e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs9611565 0.681 rs5751094 chr22:41803279 C/T cg06481639 chr22:41940642 POLR3H 0.5 5.8 0.3 1.58e-8 Vitiligo; CRC cis rs1003719 0.715 rs9974494 chr21:38566566 C/T cg10648535 chr21:38446584 PIGP;TTC3 -0.47 -6.48 -0.34 3.4e-10 Eye color traits; CRC cis rs1941023 0.503 rs10750936 chr11:60144180 G/A cg08716584 chr11:60157161 MS4A7 -0.55 -9.06 -0.45 1.15e-17 Congenital heart disease (maternal effect); CRC cis rs7647973 1.000 rs6774724 chr3:49381911 G/T cg20833759 chr3:49053208 WDR6;DALRD3 0.6 8.94 0.44 2.89e-17 Menarche (age at onset); CRC cis rs9807989 0.839 rs3755276 chr2:102978459 C/T cg03938978 chr2:103052716 IL18RAP 0.37 6.1 0.32 3.01e-9 Asthma; CRC cis rs72781680 0.752 rs72796110 chr2:23905658 T/A cg08917208 chr2:24149416 ATAD2B 1.02 9.31 0.46 1.83e-18 Lymphocyte counts; CRC cis rs9916302 0.904 rs6503506 chr17:37524653 C/A cg07936489 chr17:37558343 FBXL20 0.78 11.71 0.54 1.02e-26 Glomerular filtration rate (creatinine); CRC trans rs7395662 0.697 rs11530291 chr11:48764203 C/G cg21153622 chr11:89784906 NA 0.46 7.39 0.38 1.25e-12 HDL cholesterol; CRC cis rs7552404 1.000 rs4949879 chr1:76237143 G/A cg22875332 chr1:76189707 ACADM 0.64 8.62 0.43 2.84e-16 Blood metabolite levels;Acylcarnitine levels; CRC cis rs8010715 0.816 rs6573565 chr14:24594733 A/G cg23112188 chr14:24563095 PCK2 0.35 7.04 0.36 1.14e-11 IgG glycosylation; CRC cis rs4843747 0.605 rs28399183 chr16:88107277 G/A cg03395651 chr16:88107091 BANP 0.59 8.01 0.4 1.97e-14 Menopause (age at onset); CRC cis rs9303280 0.901 rs12103884 chr17:38045725 C/T cg20243544 chr17:37824526 PNMT 0.45 6.82 0.35 4.48e-11 Self-reported allergy; CRC trans rs587242 1.000 rs61786491 chr1:96904651 G/C cg10631902 chr5:14652156 NA 0.44 6.84 0.35 3.84e-11 Body mass index (joint analysis main effects and physical activity interaction);Body mass index in physically inactive individuals;Body mass index; CRC cis rs12410462 0.901 rs2814090 chr1:227658444 C/G cg04117972 chr1:227635322 NA -0.51 -5.83 -0.31 1.32e-8 Major depressive disorder; CRC trans rs4332037 0.950 rs62442895 chr7:1936938 G/A cg11693508 chr17:37793320 STARD3 0.69 8.21 0.41 5.02e-15 Bipolar disorder; CRC cis rs853679 0.517 rs6941992 chr6:28106141 T/C cg03623178 chr6:28175578 NA 0.96 12.57 0.57 7.23e-30 Depression; CRC cis rs4481887 1.000 rs4489592 chr1:248470697 A/T cg13385794 chr1:248469461 NA 0.37 6.4 0.33 5.27e-10 Common traits (Other); CRC cis rs3820068 0.608 rs11544523 chr1:15904318 C/T cg27534772 chr1:16042836 PLEKHM2 0.41 6.59 0.34 1.71e-10 Systolic blood pressure; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg01078248 chr7:123197661 NDUFA5 0.47 5.98 0.31 5.94e-9 Thyroid stimulating hormone; CRC cis rs995000 0.965 rs7520810 chr1:63095711 C/T cg19896129 chr1:63156450 NA 0.42 6.44 0.33 4.16e-10 Triglyceride levels; CRC cis rs1113500 0.897 rs4628530 chr1:108638708 T/G cg06207961 chr1:108661230 NA 0.39 5.75 0.3 2e-8 Growth-regulated protein alpha levels; CRC cis rs800160 0.777 rs962903 chr11:2352341 A/G cg09785033 chr11:2336066 TSPAN32 -0.54 -5.82 -0.31 1.38e-8 Bacteremia; CRC trans rs16957091 0.528 rs12908349 chr15:43086227 C/T cg15973384 chr6:168817498 NA 0.53 6.15 0.32 2.27e-9 MGMT methylation in smokers; CRC cis rs274567 0.501 rs274571 chr5:131712125 A/G cg07395648 chr5:131743802 NA 0.43 6.0 0.31 5.28e-9 Blood metabolite levels; CRC cis rs4713118 0.955 rs34752872 chr6:27683244 A/T cg12172441 chr6:28176163 NA 0.49 6.29 0.33 9.97e-10 Parkinson's disease; CRC cis rs9467711 0.606 rs34781270 chr6:26593037 A/G cg12315302 chr6:26189340 HIST1H4D 0.99 6.93 0.36 2.22e-11 Autism spectrum disorder or schizophrenia; CRC cis rs2243480 1.000 rs7778911 chr7:65694506 T/C cg12463550 chr7:65579703 CRCP -0.68 -6.04 -0.32 4.07e-9 Diabetic kidney disease; CRC cis rs4975709 0.589 rs4975707 chr5:1864028 C/T cg11168104 chr5:1857477 NA -0.38 -6.67 -0.34 1.11e-10 Cardiovascular disease risk factors; CRC cis rs477692 1.000 rs565974 chr10:131423274 C/T cg05714579 chr10:131428358 MGMT 0.55 8.13 0.41 8.91e-15 Response to temozolomide; CRC cis rs6952808 0.692 rs56727870 chr7:2029940 T/C cg04267008 chr7:1944627 MAD1L1 -0.78 -11.33 -0.53 2.45e-25 Bipolar disorder and schizophrenia; CRC cis rs2839186 0.867 rs13050387 chr21:47701423 C/T cg09417038 chr21:47716443 C21orf57 -0.41 -6.8 -0.35 4.94e-11 Testicular germ cell tumor; CRC cis rs9660180 0.967 rs10907191 chr1:1774820 A/T cg23982607 chr1:1823379 GNB1 -0.9 -15.72 -0.65 6.15e-42 Body mass index; CRC cis rs7726839 0.540 rs56325086 chr5:640728 G/A cg14541582 chr5:601475 NA -0.36 -7.25 -0.37 2.91e-12 Obesity-related traits; CRC cis rs13256369 0.901 rs13251887 chr8:8568678 G/A cg17143192 chr8:8559678 CLDN23 0.49 6.33 0.33 7.83e-10 Obesity-related traits; CRC cis rs12024301 0.557 rs116821993 chr1:183641049 T/C cg11505048 chr1:183622726 RGL1;APOBEC4 0.82 6.81 0.35 4.59e-11 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs921968 0.643 rs1850169 chr2:219487299 A/T cg02176678 chr2:219576539 TTLL4 0.48 7.48 0.38 6.73e-13 Mean corpuscular hemoglobin concentration; CRC cis rs6582630 0.555 rs7133706 chr12:38475465 G/A cg26384229 chr12:38710491 ALG10B -0.66 -9.71 -0.47 9.03e-20 Drug-induced liver injury (flucloxacillin); CRC cis rs910316 1.000 rs10142626 chr14:75555636 A/T cg11812906 chr14:75593930 NEK9 0.64 10.38 0.5 5.13e-22 Height; CRC cis rs2239547 0.657 rs6445539 chr3:52874296 G/A cg15147215 chr3:52552868 STAB1 -0.42 -5.84 -0.31 1.28e-8 Schizophrenia; CRC cis rs17767392 0.871 rs2108706 chr14:71799175 T/G cg13720639 chr14:72061746 SIPA1L1 -0.49 -6.5 -0.34 3.06e-10 Mitral valve prolapse; CRC cis rs713477 0.967 rs61976571 chr14:55908774 T/C cg13175173 chr14:55914753 NA -0.52 -9.85 -0.48 3.19e-20 Pediatric bone mineral content (femoral neck); CRC cis rs7811142 0.666 rs28401739 chr7:99905684 A/G cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.68 9.1 0.45 8.9e-18 Platelet count; CRC cis rs4808199 0.895 rs2285628 chr19:19467996 T/A cg03709012 chr19:19516395 GATAD2A 0.89 10.69 0.51 4.31e-23 Nonalcoholic fatty liver disease; CRC cis rs4660261 0.526 rs3011228 chr1:44325995 A/G cg12908607 chr1:44402522 ARTN -0.53 -9.51 -0.46 4.11e-19 Intelligence (multi-trait analysis); CRC cis rs7772486 0.720 rs702320 chr6:146006654 G/A cg05347473 chr6:146136440 FBXO30 -0.41 -6.17 -0.32 2.05e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs7552404 1.000 rs72686191 chr1:76218319 G/T cg22875332 chr1:76189707 ACADM 0.72 9.73 0.47 8.11e-20 Blood metabolite levels;Acylcarnitine levels; CRC cis rs9527 0.615 rs4919685 chr10:104587362 G/T cg15744005 chr10:104629667 AS3MT -0.35 -6.33 -0.33 8.02e-10 Arsenic metabolism; CRC cis rs2576037 0.526 rs605487 chr18:44444778 G/C cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.66 -10.68 -0.51 4.75e-23 Personality dimensions; CRC cis rs3087591 0.960 rs2952999 chr17:29509801 G/T cg24425628 chr17:29625626 OMG;NF1 0.82 15.9 0.66 1.22e-42 Hip circumference; CRC cis rs1538970 0.924 rs11211108 chr1:45891152 C/T cg05343316 chr1:45956843 TESK2 0.74 10.05 0.48 6.51e-21 Platelet count; CRC cis rs9341808 0.628 rs2490245 chr6:80892427 A/G cg08355045 chr6:80787529 NA 0.39 6.56 0.34 2.04e-10 Sitting height ratio; CRC cis rs4319547 0.615 rs2341439 chr12:122848096 C/G cg23029597 chr12:123009494 RSRC2 -0.56 -7.29 -0.37 2.3e-12 Body mass index; CRC trans rs1005277 0.579 rs1740745 chr10:38520056 T/C cg11292332 chr7:45801988 SEPT13 -0.39 -7.05 -0.36 1.05e-11 Extrinsic epigenetic age acceleration; CRC cis rs11122272 0.735 rs2749717 chr1:231489353 G/T cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.51 -7.48 -0.38 7.02e-13 Hemoglobin concentration; CRC cis rs9372498 0.536 rs72952761 chr6:118866758 A/C cg24463073 chr6:118973353 C6orf204 0.52 6.91 0.36 2.52e-11 Diastolic blood pressure; CRC cis rs6952808 0.531 rs3800922 chr7:2184505 A/G cg21782813 chr7:2030301 MAD1L1 0.5 8.33 0.42 2.18e-15 Bipolar disorder and schizophrenia; CRC cis rs765787 0.530 rs7165889 chr15:45531640 T/C cg24006582 chr15:45444508 DUOX1 -0.58 -8.85 -0.44 5.42e-17 Uric acid levels; CRC cis rs13256369 1.000 rs7820159 chr8:8576215 T/C cg06671706 chr8:8559999 CLDN23 0.53 7.56 0.38 4.11e-13 Obesity-related traits; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg07630649 chr16:75600717 GABARAPL2 0.44 6.16 0.32 2.13e-9 Anxiety disorder; CRC trans rs11148252 0.846 rs7985262 chr13:52997161 C/T cg18335740 chr13:41363409 SLC25A15 0.54 8.26 0.41 3.51e-15 Lewy body disease; CRC cis rs35883536 0.545 rs115017855 chr1:101101830 T/A cg14515779 chr1:101123966 NA -0.35 -6.18 -0.32 1.9e-9 Monocyte count; CRC trans rs1005277 0.541 rs2472177 chr10:38384015 T/G cg27523141 chr10:43048294 ZNF37B 0.5 7.39 0.38 1.19e-12 Extrinsic epigenetic age acceleration; CRC cis rs10927875 0.632 rs10927864 chr1:16165661 C/G cg21385522 chr1:16154831 NA -1.11 -21.23 -0.76 1.26e-63 Dilated cardiomyopathy; CRC cis rs1552244 0.882 rs13099136 chr3:10031431 G/A cg18598329 chr3:10140678 FANCD2;C3orf24 -0.81 -10.58 -0.5 1.08e-22 Alzheimer's disease; CRC cis rs8017423 0.647 rs12587362 chr14:90821227 G/T cg14092571 chr14:90743983 NA 0.38 5.85 0.31 1.17e-8 Mortality in heart failure; CRC cis rs1552244 0.572 rs58862481 chr3:10164308 G/A cg13047869 chr3:10149882 C3orf24 0.55 6.66 0.34 1.17e-10 Alzheimer's disease; CRC cis rs7412746 0.611 rs10888395 chr1:150762171 C/T cg17724175 chr1:150552817 MCL1 0.48 7.08 0.36 8.66e-12 Melanoma; CRC trans rs11148252 0.740 rs9526914 chr13:52976300 G/T cg18335740 chr13:41363409 SLC25A15 0.48 7.16 0.37 5.27e-12 Lewy body disease; CRC cis rs780096 0.505 rs12475426 chr2:27599132 G/A cg27432699 chr2:27873401 GPN1 -0.48 -7.24 -0.37 3.27e-12 Total body bone mineral density; CRC cis rs5758659 0.935 rs134879 chr22:42664201 A/C cg15557168 chr22:42548783 NA -0.34 -5.63 -0.3 3.8e-8 Cognitive function; CRC trans rs7618501 1.000 rs7649348 chr3:49772375 G/A cg21665057 chr3:196295764 WDR53;FBXO45 -0.86 -15.78 -0.66 3.79e-42 Intelligence (multi-trait analysis); CRC cis rs2836974 0.568 rs377098 chr21:40535216 G/A cg17971929 chr21:40555470 PSMG1 -0.74 -11.77 -0.54 6.3e-27 Cognitive function; CRC cis rs3008870 0.727 rs4582760 chr1:67464394 G/A cg08660285 chr1:67390436 MIER1;WDR78 -0.55 -7.67 -0.39 2.02e-13 Lymphocyte percentage of white cells; CRC cis rs6541297 1.000 rs1998065 chr1:230286647 T/G cg20703242 chr1:230279135 GALNT2 0.53 7.94 0.4 3.33e-14 Coronary artery disease; CRC trans rs7690467 0.794 rs35848947 chr4:133393124 C/A cg19296258 chr17:78878799 RPTOR -0.48 -6.49 -0.34 3.24e-10 Eating disorders; CRC cis rs11212617 0.902 rs599406 chr11:108118234 T/A cg01991180 chr11:108092276 ATM;NPAT 0.43 6.26 0.33 1.23e-9 Response to metformin in type 2 diabetes (glycemic); CRC cis rs9649213 0.593 rs7458551 chr7:97952167 G/C cg08684580 chr7:98029266 BAIAP2L1 -0.31 -5.62 -0.3 4.05e-8 Prostate cancer (SNP x SNP interaction); CRC cis rs9921222 0.632 rs11649268 chr16:398643 A/C cg08923669 chr16:420230 MRPL28 -0.67 -10.58 -0.5 1.05e-22 Bone mineral density (spine);Bone mineral density; CRC cis rs6840360 0.642 rs4696089 chr4:152395733 A/G cg09659197 chr4:152720779 NA 0.34 6.64 0.34 1.32e-10 Intelligence (multi-trait analysis); CRC cis rs6694672 0.867 rs568757 chr1:197218051 G/A cg13682187 chr1:196946512 CFHR5 0.49 7.01 0.36 1.39e-11 Asthma; CRC cis rs2303745 0.589 rs11882562 chr19:17395055 C/G cg02221750 chr19:17393354 ANKLE1 0.43 6.56 0.34 2.06e-10 Systemic lupus erythematosus; CRC trans rs1728785 1.000 rs1728785 chr16:68591230 G/T cg04657470 chr2:198365150 HSPE1;HSPD1 -0.74 -8.71 -0.43 1.52e-16 Ulcerative colitis; CRC cis rs758324 0.617 rs9717078 chr5:131170891 G/A cg25547332 chr5:131281432 NA 0.38 5.64 0.3 3.67e-8 Alzheimer's disease in APOE e4- carriers; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg24124398 chr17:40075096 ACLY 0.5 7.36 0.38 1.48e-12 Intelligence (multi-trait analysis); CRC cis rs7208859 0.573 rs79505916 chr17:29062326 C/T cg01831904 chr17:28903510 LRRC37B2 -0.61 -6.23 -0.32 1.45e-9 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs6662572 0.737 rs6702764 chr1:46252717 A/G cg03123370 chr1:45965343 CCDC163P;MMACHC -0.46 -6.05 -0.32 4.02e-9 Blood protein levels; CRC cis rs6032067 0.852 rs17333103 chr20:43803613 C/T cg10761708 chr20:43804764 PI3 0.48 5.64 0.3 3.58e-8 Blood protein levels; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg09041756 chr7:5570314 ACTB -0.43 -6.51 -0.34 2.79e-10 Myopia (pathological); CRC cis rs7923609 1.000 rs10822149 chr10:64987412 G/A cg08743896 chr10:65200160 JMJD1C -0.39 -5.62 -0.3 4.15e-8 Educational attainment;Liver enzyme levels (alkaline phosphatase); CRC cis rs10504229 0.593 rs76118562 chr8:57988110 G/C cg11062466 chr8:58055876 NA 0.52 6.18 0.32 1.94e-9 Developmental language disorder (linguistic errors); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg17942371 chr19:796826 PTBP1 0.4 6.03 0.32 4.39e-9 Intelligence (multi-trait analysis); CRC cis rs1005277 0.565 rs2474565 chr10:38380828 A/G cg25427524 chr10:38739819 LOC399744 -0.77 -13.69 -0.6 4.51e-34 Extrinsic epigenetic age acceleration; CRC cis rs6499255 0.951 rs56282083 chr16:69825728 C/T cg00738113 chr16:70207722 CLEC18C -0.4 -5.78 -0.3 1.72e-8 IgE levels; CRC cis rs28655083 0.529 rs285023 chr16:77099783 G/A cg01753188 chr16:77233325 SYCE1L;MON1B 0.48 6.81 0.35 4.54e-11 Lobe attachment (rater-scored or self-reported); CRC cis rs11676348 0.818 rs7425447 chr2:218980183 T/C cg00012203 chr2:219082015 ARPC2 -0.44 -6.48 -0.34 3.33e-10 Ulcerative colitis; CRC cis rs155076 1.000 rs261369 chr13:21868420 C/A cg25811766 chr13:21894605 NA -0.56 -6.01 -0.31 4.93e-9 White matter hyperintensity burden; CRC cis rs6921919 0.638 rs7772827 chr6:28301143 T/C cg21251018 chr6:28226885 NKAPL 0.47 7.09 0.36 8.23e-12 Autism spectrum disorder or schizophrenia; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg19644449 chr12:46385886 SFRS2IP 0.43 6.22 0.32 1.47e-9 Intelligence (multi-trait analysis); CRC trans rs349114 0.501 rs9554396 chr13:98115192 G/C cg04366385 chr4:78980382 FRAS1 -0.46 -6.03 -0.32 4.43e-9 Obesity-related traits; CRC cis rs7584330 0.554 rs880931 chr2:238396741 G/A cg14458575 chr2:238380390 NA 0.89 11.13 0.52 1.21e-24 Prostate cancer; CRC trans rs9929218 0.817 rs3118228 chr16:68710737 T/G cg04657470 chr2:198365150 HSPE1;HSPD1 -1.07 -16.55 -0.67 3.48e-45 Colorectal cancer; CRC trans rs916888 0.697 rs199516 chr17:44856485 C/T cg22433210 chr17:43662623 NA -0.82 -9.05 -0.45 1.27e-17 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC trans rs17685 0.558 rs60787921 chr7:75792844 C/A cg19862616 chr7:65841803 NCRNA00174 0.97 16.87 0.68 1.91e-46 Coffee consumption;Coffee consumption (cups per day); CRC cis rs2228479 0.764 rs7191836 chr16:89961597 T/C cg06558623 chr16:89946397 TCF25 0.79 8.65 0.43 2.34e-16 Skin colour saturation; CRC cis rs4665809 0.590 rs2303892 chr2:26461733 C/G cg25036284 chr2:26402008 FAM59B 0.62 7.86 0.4 5.64e-14 Gut microbiome composition (summer); CRC cis rs7927771 0.832 rs4752990 chr11:47410393 G/A cg20307385 chr11:47447363 PSMC3 -0.66 -9.5 -0.46 4.65e-19 Subjective well-being; CRC cis rs6952808 0.792 rs13224989 chr7:1953766 C/G cg02951883 chr7:2050386 MAD1L1 -0.69 -11.09 -0.52 1.77e-24 Bipolar disorder and schizophrenia; CRC trans rs116095464 0.558 rs10055993 chr5:264296 A/C cg00938859 chr5:1591904 SDHAP3 0.69 6.09 0.32 3.22e-9 Breast cancer; CRC trans rs561341 0.883 rs72821942 chr17:30234460 C/T cg20587970 chr11:113659929 NA -1.04 -12.8 -0.58 1.0500000000000001e-30 Hip circumference adjusted for BMI; CRC trans rs1814175 0.587 rs847628 chr11:49927064 A/T cg15704280 chr7:45808275 SEPT13 -0.95 -16.82 -0.68 3.11e-46 Height; CRC cis rs1552244 0.572 rs7645759 chr3:10157368 C/T cg00166722 chr3:10149974 C3orf24 0.66 7.67 0.39 1.96e-13 Alzheimer's disease; CRC cis rs832540 0.519 rs6895442 chr5:56260998 T/C cg18230493 chr5:56204884 C5orf35 -0.39 -5.92 -0.31 7.95e-9 Coronary artery disease; CRC cis rs4862750 0.832 rs9995958 chr4:187901764 G/A cg11301795 chr4:187892539 NA -0.87 -20.32 -0.75 4.87e-60 Lobe attachment (rater-scored or self-reported); CRC trans rs4576506 0.536 rs13302490 chr9:31501013 C/T cg26940518 chr16:1593766 IFT140;TMEM204 -0.65 -5.97 -0.31 6.1e-9 Psychosis and Alzheimer's disease; CRC cis rs2898681 0.561 rs58577680 chr4:53734294 C/T cg00791764 chr4:53727839 RASL11B 0.47 6.16 0.32 2.15e-9 Optic nerve measurement (cup area); CRC cis rs2294693 0.945 rs742494 chr6:41007835 A/T cg14769373 chr6:40998127 UNC5CL -0.47 -6.03 -0.32 4.3e-9 Gastric cancer;Non-cardia gastric cancer; CRC cis rs9322193 0.851 rs9322194 chr6:149920249 C/T cg13206674 chr6:150067644 NUP43 0.66 9.7 0.47 1.02e-19 Lung cancer; CRC cis rs6163 0.540 rs11191385 chr10:104513049 G/T cg04362960 chr10:104952993 NT5C2 0.52 6.25 0.33 1.3e-9 Waist circumference;Hip circumference; CRC cis rs6502050 0.835 rs6502077 chr17:80122966 G/C cg13198984 chr17:80129470 CCDC57 0.47 8.35 0.42 1.88e-15 Life satisfaction; CRC cis rs853679 0.517 rs9348794 chr6:28117757 T/A cg12273811 chr6:28175739 NA 0.73 9.16 0.45 5.8e-18 Depression; CRC cis rs3806843 1.000 rs9686540 chr5:140174622 G/A cg19875535 chr5:140030758 IK 0.6 9.84 0.48 3.35e-20 Depressive symptoms (multi-trait analysis); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg03157738 chr19:11308118 KANK2 0.46 6.41 0.33 5.04e-10 Response to antipsychotic treatment; CRC cis rs9611565 0.722 rs202635 chr22:41809637 C/T cg03806693 chr22:41940476 POLR3H 0.99 12.49 0.57 1.47e-29 Vitiligo; CRC cis rs736408 0.812 rs9324 chr3:52825585 T/C cg15147215 chr3:52552868 STAB1 -0.57 -9.06 -0.45 1.17e-17 Bipolar disorder; CRC cis rs7493 1.000 rs17876124 chr7:95045258 C/G cg04155289 chr7:94953770 PON1 -0.59 -7.48 -0.38 6.83e-13 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs7666738 0.830 rs13137808 chr4:99047095 T/C cg17366294 chr4:99064904 C4orf37 0.45 7.75 0.39 1.16e-13 Colonoscopy-negative controls vs population controls; CRC cis rs860295 0.702 rs11264381 chr1:155522572 C/T cg02153340 chr1:155202674 NA 0.55 6.57 0.34 1.93e-10 Body mass index; CRC cis rs7666738 0.791 rs7657399 chr4:98851861 T/C cg05340658 chr4:99064831 C4orf37 0.57 8.45 0.42 9.23e-16 Colonoscopy-negative controls vs population controls; CRC cis rs6570726 0.791 rs1280275 chr6:145892402 C/T cg23711669 chr6:146136114 FBXO30 0.69 11.52 0.54 4.94e-26 Lobe attachment (rater-scored or self-reported); CRC cis rs1223397 0.651 rs2458311 chr6:13310012 T/C cg07912922 chr6:13274314 PHACTR1 0.39 6.07 0.32 3.52e-9 Blood pressure; CRC cis rs6879260 1.000 rs6879260 chr5:179731014 A/G cg23248424 chr5:179741104 GFPT2 -0.62 -9.7 -0.47 9.85e-20 Height; CRC cis rs738322 0.967 rs132985 chr22:38563471 C/T cg17652424 chr22:38574118 PLA2G6 -0.22 -6.84 -0.35 3.81e-11 Cutaneous nevi; CRC cis rs9322193 0.923 rs9383812 chr6:150033491 C/T cg00933542 chr6:150070202 PCMT1 0.32 6.57 0.34 1.94e-10 Lung cancer; CRC cis rs4363385 0.747 rs1577962 chr1:152962013 A/G cg25856811 chr1:152973957 SPRR3 -0.26 -7.32 -0.37 1.93e-12 Inflammatory skin disease; CRC cis rs9467711 0.538 rs9467626 chr6:25873746 C/A cg12315302 chr6:26189340 HIST1H4D 0.72 5.76 0.3 1.96e-8 Autism spectrum disorder or schizophrenia; CRC cis rs4680 0.737 rs4646312 chr22:19948337 C/T cg22546130 chr22:19950026 COMT 0.29 7.71 0.39 1.5e-13 Blood metabolite levels; CRC cis rs2692947 0.763 rs7570074 chr2:96407037 T/C cg23100626 chr2:96804247 ASTL 0.26 6.7 0.35 9.03e-11 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; CRC cis rs10791323 0.517 rs1120247 chr11:133745180 T/G cg06766960 chr11:133703094 NA -0.32 -5.75 -0.3 2.05e-8 Childhood ear infection; CRC cis rs9457247 0.565 rs12178491 chr6:167512474 C/T cg07741184 chr6:167504864 NA 0.49 8.1 0.41 1.07e-14 Crohn's disease; CRC cis rs798554 0.759 rs1636255 chr7:2892804 A/C cg17321639 chr7:2759063 NA 0.5 6.46 0.34 3.86e-10 Height; CRC cis rs992157 0.735 rs13430006 chr2:219113089 A/C cg00012203 chr2:219082015 ARPC2 -0.61 -10.34 -0.5 7.09e-22 Colorectal cancer; CRC cis rs832540 0.618 rs2548663 chr5:56172778 G/A cg03609598 chr5:56110824 MAP3K1 -0.45 -5.9 -0.31 9.09e-9 Coronary artery disease; CRC cis rs71403859 0.502 rs71403849 chr16:71484365 T/C cg08717414 chr16:71523259 ZNF19 -0.89 -9.63 -0.47 1.67e-19 Post bronchodilator FEV1; CRC cis rs3760982 0.845 rs62116962 chr19:44287234 A/G cg12072164 chr19:44306565 LYPD5 -0.41 -6.4 -0.33 5.49e-10 Breast cancer (estrogen-receptor negative);Breast cancer; CRC cis rs7216064 1.000 rs62084240 chr17:65859233 C/A cg12091567 chr17:66097778 LOC651250 -0.67 -7.59 -0.39 3.28e-13 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CRC cis rs514406 0.644 rs6661196 chr1:53203664 A/G cg25767906 chr1:53392781 SCP2 0.37 5.83 0.31 1.3e-8 Monocyte count; CRC cis rs735396 0.770 rs2264782 chr12:121432603 C/T cg02403541 chr12:121454288 C12orf43 0.45 6.78 0.35 5.51e-11 N-glycan levels; CRC cis rs7591163 1.000 rs2396499 chr2:228724368 C/T cg08034379 chr2:228736324 WDR69 0.48 6.35 0.33 7.05e-10 Blood pressure; CRC cis rs7769051 0.522 rs56908272 chr6:133102165 G/C cg07930552 chr6:133119739 C6orf192 0.74 6.09 0.32 3.13e-9 Type 2 diabetes nephropathy; CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg22625903 chr11:62313283 AHNAK -0.51 -6.1 -0.32 2.96e-9 Diisocyanate-induced asthma; CRC cis rs853679 1.000 rs11965538 chr6:28239915 G/A cg15845792 chr6:28175446 NA 0.65 6.49 0.34 3.17e-10 Depression; CRC cis rs12701220 0.520 rs7803208 chr7:1162084 C/T cg04025307 chr7:1156635 C7orf50 0.42 5.77 0.3 1.81e-8 Bronchopulmonary dysplasia; CRC trans rs2228479 0.867 rs11645970 chr16:89958118 G/A cg21302420 chr1:112162376 RAP1A 0.81 7.43 0.38 9.4e-13 Skin colour saturation; CRC cis rs6461049 0.800 rs3800913 chr7:2163237 A/G cg22963979 chr7:1858916 MAD1L1 -0.4 -5.94 -0.31 7.29e-9 Schizophrenia; CRC cis rs9467711 0.659 rs35555795 chr6:26509382 C/T cg16898833 chr6:26189333 HIST1H4D 1.14 8.46 0.42 8.89e-16 Autism spectrum disorder or schizophrenia; CRC cis rs10911232 0.507 rs4397624 chr1:183053131 C/T ch.1.3577855R chr1:183094577 LAMC1 0.84 14.59 0.63 1.55e-37 Hypertriglyceridemia; CRC cis rs6692209 1 rs6692209 chr1:152506444 C/T cg23254163 chr1:152506842 NA 0.5 10.23 0.49 1.62e-21 Plantar warts; CRC cis rs1707322 0.785 rs10890348 chr1:46242423 G/T cg03146154 chr1:46216737 IPP 0.64 9.11 0.45 8.07e-18 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC trans rs8123881 0.733 rs7268466 chr20:15810676 C/T cg06767701 chr1:152008878 S100A11 0.61 6.38 0.33 6.04e-10 Body mass index; CRC cis rs56283067 0.847 rs2128543 chr6:44685552 G/A cg18551225 chr6:44695536 NA -0.42 -6.08 -0.32 3.34e-9 Total body bone mineral density; CRC cis rs12048904 0.619 rs3737581 chr1:101341083 A/G cg16556008 chr1:101360663 SLC30A7;EXTL2 0.89 14.53 0.63 2.62e-37 Multiple sclerosis; CRC cis rs6918586 0.658 rs198821 chr6:26123629 T/C cg18357526 chr6:26021779 HIST1H4A -0.49 -7.44 -0.38 9.1e-13 Schizophrenia; CRC cis rs8031584 0.678 rs8028173 chr15:31155749 A/G cg08704250 chr15:31115839 NA -0.56 -9.87 -0.48 2.78e-20 Huntington's disease progression; CRC cis rs1348850 0.918 rs4893966 chr2:178470138 A/G cg22681709 chr2:178499509 PDE11A -0.39 -7.27 -0.37 2.56e-12 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs4713118 0.869 rs9295743 chr6:27715102 G/C cg25164649 chr6:28176230 NA 0.59 8.33 0.42 2.22e-15 Parkinson's disease; CRC cis rs10504229 0.683 rs16921807 chr8:58105967 C/T cg21724239 chr8:58056113 NA 0.52 6.99 0.36 1.58e-11 Developmental language disorder (linguistic errors); CRC cis rs2708977 0.666 rs17685664 chr2:97315570 C/T cg01950434 chr2:97203154 ARID5A 0.48 6.74 0.35 7.1e-11 Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes; CRC cis rs1008375 1.000 rs56974987 chr4:17627856 G/A cg16339924 chr4:17578868 LAP3 0.55 7.46 0.38 7.93e-13 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs400736 0.930 rs225119 chr1:8044361 T/C cg25007680 chr1:8021821 PARK7 0.55 7.71 0.39 1.48e-13 Response to antidepressants and depression; CRC cis rs826838 0.967 rs826876 chr12:39123843 T/C cg13010199 chr12:38710504 ALG10B -0.39 -5.67 -0.3 3.06e-8 Heart rate; CRC cis rs875971 0.540 rs4717275 chr7:65265180 C/T cg18876405 chr7:65276391 NA -0.66 -12.15 -0.56 2.54e-28 Aortic root size; CRC cis rs741668 0.897 rs17429573 chr13:46570058 T/C cg06018095 chr13:46550134 ZC3H13 0.41 5.73 0.3 2.21e-8 Cerebrospinal fluid clusterin levels; CRC cis rs394563 0.591 rs237012 chr6:149729198 T/C cg03678062 chr6:149772716 ZC3H12D -0.35 -6.43 -0.33 4.61e-10 Dupuytren's disease; CRC cis rs919433 0.680 rs1563340 chr2:198414713 A/T cg10820045 chr2:198174542 NA 0.39 6.33 0.33 7.85e-10 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC cis rs2012796 1.000 rs8009171 chr14:81820060 G/A cg02996355 chr14:81879375 NA 0.51 7.54 0.38 4.63e-13 Night sleep phenotypes; CRC trans rs4263408 0.934 rs9683743 chr4:39703194 A/C cg10499166 chr1:23345815 KDM1A -0.44 -6.51 -0.34 2.87e-10 Plasma amyloid beta peptide concentrations (ABx-40); CRC cis rs4728302 0.869 rs13233690 chr7:133587328 C/T cg10665199 chr7:133106180 EXOC4 0.38 5.8 0.3 1.54e-8 Intelligence;Intelligence (multi-trait analysis); CRC cis rs3087591 0.683 rs7502556 chr17:29642430 T/C cg24425628 chr17:29625626 OMG;NF1 0.73 13.11 0.59 6.95e-32 Hip circumference; CRC cis rs9323205 0.798 rs2999391 chr14:51655109 A/G cg23942311 chr14:51606299 NA 0.61 9.08 0.45 1.01e-17 Cancer; CRC cis rs8180040 0.577 rs12493425 chr3:47176946 T/G cg27129171 chr3:47204927 SETD2 0.71 11.29 0.53 3.36e-25 Colorectal cancer; CRC cis rs7044106 0.791 rs3904196 chr9:123480369 T/C cg14255062 chr9:123606675 PSMD5;LOC253039 0.49 7.45 0.38 8.08e-13 Hip circumference adjusted for BMI; CRC cis rs78456975 1.000 rs28742145 chr2:1562671 T/C cg12573674 chr2:1569213 NA -0.74 -7.7 -0.39 1.59e-13 Placebo response in major depressive disorder (% change in symptom score); CRC cis rs17234274 0.549 rs4922645 chr11:23233722 G/A cg05245346 chr11:23248277 NA 0.35 5.66 0.3 3.29e-8 Cancer; CRC cis rs13082711 0.911 rs17019721 chr3:27424799 A/G cg02860705 chr3:27208620 NA 0.6 8.69 0.43 1.75e-16 Systolic blood pressure;Diastolic blood pressure;Blood pressure; CRC cis rs9894429 1.000 rs9748176 chr17:79584043 C/G cg18240062 chr17:79603768 NPLOC4 0.56 9.26 0.45 2.75e-18 Eye color traits; CRC trans rs57221529 0.766 rs17563576 chr5:560476 A/G cg25482853 chr8:67687455 SGK3 1.16 14.93 0.64 7.8e-39 Lung disease severity in cystic fibrosis; CRC cis rs2115630 1.000 rs56074163 chr15:85351332 C/T cg11189052 chr15:85197271 WDR73 -0.6 -9.84 -0.48 3.52e-20 P wave terminal force; CRC cis rs3026101 0.723 rs1806248 chr17:5310411 T/G cg25236894 chr17:5323110 RPAIN;NUP88 0.42 6.9 0.36 2.74e-11 Body mass index; CRC cis rs40363 0.680 rs4010628 chr16:3529779 G/A cg05754148 chr16:3507555 NAT15 0.61 5.7 0.3 2.65e-8 Tuberculosis; CRC cis rs1862618 0.802 rs832547 chr5:56183941 C/G cg03609598 chr5:56110824 MAP3K1 -0.85 -10.06 -0.49 6.18e-21 Initial pursuit acceleration; CRC cis rs2019137 0.560 rs10206269 chr2:113990393 C/A cg25243455 chr2:114033360 PAX8;LOC440839 -0.31 -7.31 -0.37 2e-12 Lymphocyte counts; CRC cis rs936229 0.784 rs12906946 chr15:75153140 A/G cg10253484 chr15:75165896 SCAMP2 -0.46 -7.02 -0.36 1.32e-11 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); CRC cis rs16852403 0.548 rs387917 chr1:178117542 G/A cg00404053 chr1:178313656 RASAL2 -0.49 -6.43 -0.33 4.48e-10 Childhood ear infection; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg06247283 chr18:29302528 NA 0.44 6.38 0.33 5.86e-10 Response to antipsychotic treatment; CRC cis rs4713118 0.621 rs4713133 chr6:28034041 T/C cg23161317 chr6:28129485 ZNF389 0.51 6.52 0.34 2.6200000000000003e-10 Parkinson's disease; CRC cis rs12540874 0.698 rs3807566 chr7:50564204 G/T cg14593290 chr7:50529359 DDC -0.47 -6.61 -0.34 1.56e-10 Systemic sclerosis; CRC cis rs300703 0.719 rs389621 chr2:206636 C/T cg21211680 chr2:198530 NA -0.85 -10.19 -0.49 2.32e-21 Blood protein levels; CRC cis rs12134245 0.776 rs12137878 chr1:91973210 G/T cg21854759 chr1:92012499 NA -0.54 -8.81 -0.44 7.17e-17 Breast cancer; CRC trans rs35110281 0.774 rs2838327 chr21:45018566 A/C cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.42 6.77 0.35 6.06e-11 Mean corpuscular volume; CRC cis rs11190604 1.000 rs7080356 chr10:102266735 A/C cg07080220 chr10:102295463 HIF1AN 0.46 5.8 0.3 1.52e-8 Palmitoleic acid (16:1n-7) levels; CRC cis rs898097 0.625 rs2125479 chr17:80890262 A/G cg03160526 chr17:80928410 B3GNTL1 -0.47 -7.2 -0.37 4e-12 Breast cancer; CRC cis rs12282928 0.959 rs7120768 chr11:48264835 T/A cg20307385 chr11:47447363 PSMC3 0.49 6.02 0.31 4.78e-9 Migraine - clinic-based; CRC cis rs2108225 0.934 rs2301988 chr7:107443833 A/G cg18560240 chr7:107437656 SLC26A3 0.55 8.31 0.42 2.54e-15 Ulcerative colitis; CRC cis rs79387448 0.745 rs72995626 chr2:103162580 T/C cg00507830 chr2:103233733 NA 0.51 5.61 0.3 4.25e-8 Gut microbiota (bacterial taxa); CRC cis rs7586879 0.616 rs11900505 chr2:25131986 A/C cg04586622 chr2:25135609 ADCY3 -0.54 -9.97 -0.48 1.25e-20 Body mass index; CRC cis rs12142240 0.698 rs66972124 chr1:46807445 A/G cg00530320 chr1:46809349 NSUN4 0.58 7.98 0.4 2.46e-14 Menopause (age at onset); CRC cis rs8180040 0.726 rs11130112 chr3:47024495 G/T cg02527881 chr3:46936655 PTH1R -0.43 -7.79 -0.39 8.88e-14 Colorectal cancer; CRC cis rs10512697 0.655 rs35099902 chr5:3473373 T/C cg19473799 chr5:3511975 NA -0.83 -6.35 -0.33 7.32e-10 Immune response to smallpox vaccine (IL-6); CRC cis rs873946 0.504 rs4880275 chr10:134576552 C/T cg26818010 chr10:134567672 INPP5A -0.6 -8.3 -0.42 2.65e-15 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CRC cis rs6089584 0.888 rs6061981 chr20:60618973 T/C cg13770153 chr20:60521292 NA -0.58 -8.81 -0.44 7.37e-17 Body mass index; CRC cis rs7618915 0.547 rs2336542 chr3:52710636 A/G cg11645453 chr3:52864694 ITIH4 0.35 6.14 0.32 2.31e-9 Bipolar disorder; CRC cis rs9467711 0.651 rs13206443 chr6:26119245 C/T cg19084075 chr6:26124329 HIST1H2AC;HIST1H2BC 0.68 5.6 0.3 4.45e-8 Autism spectrum disorder or schizophrenia; CRC cis rs847649 1.000 rs11514917 chr7:102609221 A/C cg18108683 chr7:102477205 FBXL13 -0.56 -9.19 -0.45 4.6e-18 Morning vs. evening chronotype; CRC cis rs9326248 0.954 rs521171 chr11:117064693 C/G cg10130564 chr11:117069849 TAGLN 0.37 6.84 0.35 3.76e-11 Blood protein levels; CRC cis rs1784581 0.674 rs1789990 chr6:162406957 G/T cg17173639 chr6:162384350 PARK2 -0.63 -10.52 -0.5 1.68e-22 Itch intensity from mosquito bite; CRC cis rs8060686 0.545 rs78229587 chr16:68165243 T/C cg26727032 chr16:67993705 SLC12A4 -0.56 -6.31 -0.33 9.02e-10 HDL cholesterol;Metabolic syndrome; CRC cis rs2252521 0.583 rs317732 chr7:29089183 A/G cg11728747 chr7:29037910 CPVL -0.48 -6.75 -0.35 6.72e-11 Cognitive performance; CRC cis rs972578 1.000 rs5759071 chr22:43375950 C/T cg01576275 chr22:43409880 NA -0.47 -7.45 -0.38 8.05e-13 Mean platelet volume; CRC cis rs4700695 0.925 rs12518262 chr5:65414004 A/G cg21114390 chr5:65439923 SFRS12 -0.59 -6.94 -0.36 2.09e-11 Facial morphology (factor 19); CRC trans rs11039798 0.588 rs6485857 chr11:48556511 C/A cg03929089 chr4:120376271 NA 0.65 6.72 0.35 8.24e-11 Axial length; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg17677112 chr7:77428730 PHTF2;TMEM60 0.46 6.55 0.34 2.17e-10 Response to antipsychotic treatment; CRC cis rs7927771 1.000 rs35624992 chr11:47615798 G/C cg18512352 chr11:47633146 NA -0.48 -9.61 -0.47 1.97e-19 Subjective well-being; CRC cis rs4766646 0.619 rs4766637 chr12:110292155 A/C cg01252219 chr12:110302105 GLTP 0.4 6.17 0.32 2.06e-9 Metabolite levels (MHPG); CRC cis rs3764400 0.567 rs2109983 chr17:46207148 A/G cg10706073 chr17:46328419 SKAP1 0.58 6.26 0.33 1.22e-9 Body mass index; CRC cis rs9527 0.615 rs11191489 chr10:104740568 C/A cg04362960 chr10:104952993 NT5C2 0.62 8.7 0.43 1.66e-16 Arsenic metabolism; CRC cis rs863345 0.604 rs11265003 chr1:158490631 C/T cg12129480 chr1:158549410 OR10X1 -0.3 -6.25 -0.33 1.25e-9 Pneumococcal bacteremia; CRC cis rs9287719 0.649 rs12621977 chr2:10721931 T/C cg00105475 chr2:10696890 NA 0.44 7.0 0.36 1.43e-11 Prostate cancer; CRC cis rs9494145 0.648 rs7758845 chr6:135428537 A/C cg22676075 chr6:135203613 NA 0.49 6.43 0.33 4.36e-10 Mean platelet volume;Platelet count;Fetal hemoglobin levels in sickle cell anemia;Red blood cell traits; CRC cis rs7107174 0.681 rs4340079 chr11:78007920 C/T cg02023728 chr11:77925099 USP35 0.54 8.57 0.43 3.97e-16 Testicular germ cell tumor; CRC cis rs28386778 0.897 rs3785572 chr17:61829989 C/T cg07362569 chr17:61921086 SMARCD2 0.37 5.73 0.3 2.27e-8 Prudent dietary pattern; CRC cis rs9322193 0.923 rs12211511 chr6:150066342 G/C cg07701084 chr6:150067640 NUP43 0.47 6.7 0.35 9.25e-11 Lung cancer; CRC cis rs1552244 1.000 rs112509186 chr3:10156533 A/G cg18598329 chr3:10140678 FANCD2;C3orf24 -0.88 -11.62 -0.54 2.25e-26 Alzheimer's disease; CRC cis rs6952808 0.582 rs11763870 chr7:2027448 T/C cg00106254 chr7:1943704 MAD1L1 0.4 6.12 0.32 2.6e-9 Bipolar disorder and schizophrenia; CRC cis rs929354 0.772 rs1182364 chr7:157017912 T/C cg17757837 chr7:157058334 UBE3C -0.76 -12.96 -0.58 2.5e-31 Body mass index; CRC cis rs2204008 0.582 rs11179135 chr12:38204689 A/C cg26384229 chr12:38710491 ALG10B 0.64 8.19 0.41 5.89e-15 Bladder cancer; CRC cis rs7605827 0.930 rs7574879 chr2:15698083 C/G cg19274914 chr2:15703543 NA 0.37 5.65 0.3 3.57e-8 Educational attainment (years of education); CRC cis rs9322193 0.923 rs2185352 chr6:150035776 T/G cg13206674 chr6:150067644 NUP43 0.65 9.76 0.47 6.08e-20 Lung cancer; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg15704304 chr12:68881427 NA -0.4 -6.57 -0.34 2.02e-10 Liver disease severity in Alagille syndrome; CRC cis rs2153535 0.562 rs9379211 chr6:8463927 C/T cg21535247 chr6:8435926 SLC35B3 0.5 7.53 0.38 4.89e-13 Motion sickness; CRC cis rs10504229 0.635 rs72649130 chr8:58053810 G/T cg22535103 chr8:58192502 C8orf71 -0.8 -8.67 -0.43 1.93e-16 Developmental language disorder (linguistic errors); CRC cis rs2070677 0.935 rs12261048 chr10:135407923 A/G cg16964102 chr10:135390573 NA 0.52 7.05 0.36 1.04e-11 Gout; CRC cis rs3820068 0.581 rs16851819 chr1:15918739 C/T cg27534772 chr1:16042836 PLEKHM2 -0.55 -10.71 -0.51 3.71e-23 Systolic blood pressure; CRC cis rs1881797 1.000 rs12061460 chr1:247686787 G/A cg11166453 chr1:247681781 NA 0.43 7.0 0.36 1.48e-11 Acute lymphoblastic leukemia (childhood); CRC cis rs4713118 0.591 rs2056924 chr6:27690174 G/A cg25164649 chr6:28176230 NA 0.52 7.43 0.38 9.73e-13 Parkinson's disease; CRC cis rs2839186 0.632 rs17176110 chr21:47706535 C/A cg02776659 chr21:47717406 C21orf57 -0.36 -5.95 -0.31 7e-9 Testicular germ cell tumor; CRC cis rs10857712 0.703 rs1056521 chr10:135235890 T/C cg19623624 chr10:135278901 LOC619207 -0.35 -5.83 -0.31 1.33e-8 Systemic lupus erythematosus; CRC cis rs68170813 0.522 rs12531187 chr7:106963650 C/G cg02696742 chr7:106810147 HBP1 -0.57 -6.13 -0.32 2.49e-9 Coronary artery disease; CRC cis rs736408 0.609 rs62255396 chr3:52782839 C/T cg15147215 chr3:52552868 STAB1 -0.61 -9.99 -0.48 1.06e-20 Bipolar disorder; CRC cis rs34526934 0.608 rs7591820 chr2:177028144 G/T cg09355771 chr2:177043147 NA -0.51 -6.49 -0.34 3.14e-10 Obstructive sleep apnea trait (apnea hypopnea index); CRC cis rs10504229 0.953 rs17805380 chr8:58171128 C/A cg22535103 chr8:58192502 C8orf71 -0.82 -12.27 -0.56 9.63e-29 Developmental language disorder (linguistic errors); CRC cis rs8005677 1.000 rs8006396 chr14:23380850 A/G cg01529538 chr14:23388837 RBM23 0.4 6.16 0.32 2.14e-9 Cognitive ability (multi-trait analysis); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg19202786 chr6:166797286 BRP44L 0.45 6.25 0.33 1.28e-9 Response to antipsychotic treatment; CRC cis rs155076 1.000 rs261423 chr13:21852331 A/C cg25811766 chr13:21894605 NA -0.59 -6.14 -0.32 2.33e-9 White matter hyperintensity burden; CRC cis rs3806843 0.900 rs2563254 chr5:140142701 T/C cg16607685 chr5:140181889 PCDHA2;PCDHA1;PCDHA3 0.26 5.99 0.31 5.59e-9 Depressive symptoms (multi-trait analysis); CRC cis rs4604732 0.578 rs112449432 chr1:247624180 T/C cg02104434 chr1:247694406 LOC148824;OR2C3 0.63 9.38 0.46 1.09e-18 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CRC cis rs59104589 0.583 rs57576464 chr2:242240697 C/T cg19488206 chr2:242435732 STK25 0.48 6.72 0.35 7.88e-11 Fibrinogen levels; CRC cis rs4253772 0.591 rs8143066 chr22:46656607 C/T cg09491104 chr22:46646882 C22orf40 -0.47 -7.34 -0.37 1.74e-12 LDL cholesterol;Cholesterol, total; CRC trans rs7580658 0.614 rs7585198 chr2:127962635 C/T cg25336731 chr2:70520884 SNRPG -0.42 -6.18 -0.32 1.88e-9 Protein C levels; CRC cis rs9611565 0.512 rs5751147 chr22:42139054 G/A cg03806693 chr22:41940476 POLR3H 1.09 13.48 0.6 2.82e-33 Vitiligo; CRC cis rs921968 0.565 rs7599365 chr2:219620566 G/A cg02176678 chr2:219576539 TTLL4 -0.39 -6.32 -0.33 8.72e-10 Mean corpuscular hemoglobin concentration; CRC cis rs2979489 0.891 rs2915590 chr8:30393334 A/G cg26383811 chr8:30366931 RBPMS -0.67 -9.94 -0.48 1.62e-20 Mean corpuscular hemoglobin;Plateletcrit;Neutrophil count;Granulocyte count;Sum basophil neutrophil counts;Mean corpuscular volume;Myeloid white cell count;Sum neutrophil eosinophil counts; CRC cis rs4713118 0.662 rs149946 chr6:27970031 A/C cg03623178 chr6:28175578 NA -0.86 -12.65 -0.57 3.81e-30 Parkinson's disease; CRC cis rs1387259 0.758 rs2634670 chr12:48771877 G/A cg21466736 chr12:48725269 NA -0.52 -7.69 -0.39 1.78e-13 Obstructive sleep apnea trait (apnea hypopnea index); CRC cis rs6062302 0.522 rs3787112 chr20:62222411 G/A cg09650180 chr20:62225654 GMEB2 -0.5 -6.6 -0.34 1.67e-10 Glioblastoma; CRC cis rs6456156 0.742 rs1331299 chr6:167533467 A/G cg07513332 chr6:167530253 CCR6 0.44 8.3 0.42 2.73e-15 Primary biliary cholangitis; CRC cis rs6500602 0.702 rs11076834 chr16:4549583 C/G cg08645402 chr16:4508243 NA 0.59 10.38 0.5 4.93e-22 Schizophrenia; CRC cis rs9926296 0.715 rs2115401 chr16:89740609 A/G cg01097406 chr16:89675127 NA -0.43 -7.96 -0.4 2.86e-14 Vitiligo; CRC cis rs9443189 0.570 rs661229 chr6:76293793 G/A cg01950844 chr6:76311363 SENP6 0.74 9.8 0.48 4.62e-20 Prostate cancer; CRC trans rs2795502 1.000 rs2473119 chr10:43339038 A/T cg06791473 chr12:49259579 RND1 0.62 6.04 0.32 4.13e-9 Blood protein levels; CRC cis rs4660306 0.744 rs11211113 chr1:45923668 T/C cg03123370 chr1:45965343 CCDC163P;MMACHC 0.51 6.78 0.35 5.43e-11 Homocysteine levels; CRC cis rs8180040 0.603 rs9854790 chr3:47101306 T/G cg27129171 chr3:47204927 SETD2 0.72 11.42 0.53 1.1e-25 Colorectal cancer; CRC cis rs992157 0.560 rs10932763 chr2:219085863 G/C cg04731861 chr2:219085781 ARPC2 0.37 7.99 0.4 2.37e-14 Colorectal cancer; CRC cis rs9488822 0.676 rs1338667 chr6:116323910 T/A cg15226275 chr6:116381976 FRK 0.3 8.5 0.42 6.55e-16 Cholesterol, total;LDL cholesterol; CRC cis rs2075371 0.932 rs2241332 chr7:133969439 A/G cg11752832 chr7:134001865 SLC35B4 0.43 6.22 0.32 1.51e-9 Mean platelet volume; CRC trans rs61931739 0.534 rs11052960 chr12:33997754 A/T cg26384229 chr12:38710491 ALG10B 0.52 6.53 0.34 2.52e-10 Morning vs. evening chronotype; CRC cis rs17023223 0.537 rs6662165 chr1:119614071 T/G cg05756136 chr1:119680316 WARS2 -0.54 -7.24 -0.37 3.25e-12 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for BMI in active individuals; CRC cis rs7618915 0.547 rs4687636 chr3:52633929 G/A cg10802521 chr3:52805072 NEK4 -0.59 -8.96 -0.44 2.47e-17 Bipolar disorder; CRC cis rs7617773 0.743 rs71323397 chr3:48374874 A/G cg11946769 chr3:48343235 NME6 0.74 9.91 0.48 2.03e-20 Coronary artery disease; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg05658717 chr12:118407033 KSR2 0.39 6.32 0.33 8.68e-10 Liver disease severity in Alagille syndrome; CRC cis rs763121 0.889 rs6001209 chr22:39121252 C/T cg06544989 chr22:39130855 UNC84B -0.42 -6.57 -0.34 2.02e-10 Menopause (age at onset); CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg14824382 chr8:144680115 EEF1D;TIGD5 -0.43 -6.9 -0.36 2.76e-11 Myopia (pathological); CRC cis rs10504229 0.683 rs56211106 chr8:58113497 A/G cg21724239 chr8:58056113 NA 0.49 6.77 0.35 5.94e-11 Developmental language disorder (linguistic errors); CRC cis rs7044106 0.762 rs966397 chr9:123453312 G/A cg09419670 chr9:123605666 PSMD5;LOC253039 0.7 11.58 0.54 3.07e-26 Hip circumference adjusted for BMI; CRC cis rs12701220 0.744 rs10499317 chr7:1012103 C/G cg26769984 chr7:1090371 C7orf50 0.51 7.29 0.37 2.32e-12 Bronchopulmonary dysplasia; CRC cis rs1862618 0.853 rs11739344 chr5:56111087 A/C cg20203395 chr5:56204925 C5orf35 -0.73 -8.59 -0.43 3.57e-16 Initial pursuit acceleration; CRC cis rs11209185 0.509 rs2419044 chr1:68421087 C/T cg22082780 chr1:68452167 NA 0.38 5.83 0.31 1.3e-8 Itch intensity from mosquito bite adjusted by bite size; CRC cis rs60733400 0.782 rs4648564 chr1:2562169 C/T cg18854424 chr1:2615690 NA -0.47 -9.17 -0.45 5.15e-18 Multiple sclerosis; CRC cis rs4819052 0.851 rs2838834 chr21:46665208 C/T cg02159808 chr21:46707872 POFUT2;LOC642852 0.54 7.22 0.37 3.68e-12 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC trans rs853679 0.882 rs2743555 chr6:28241081 G/A cg06606381 chr12:133084897 FBRSL1 -0.64 -6.29 -0.33 1.01e-9 Depression; CRC cis rs6662572 0.737 rs11211211 chr1:46340554 G/T cg08644498 chr1:46502608 NA -0.45 -7.07 -0.36 9.42e-12 Blood protein levels; CRC cis rs904251 0.523 rs2776871 chr6:37481759 A/G cg25019722 chr6:37503610 NA -0.47 -8.68 -0.43 1.86e-16 Cognitive performance; CRC trans rs3118914 1.000 rs3118912 chr13:51111464 C/T cg09222023 chr3:138669322 C3orf72 0.35 6.0 0.31 5.26e-9 Height; CRC cis rs9372498 0.505 rs62424204 chr6:118861642 G/A cg01339444 chr6:118972232 C6orf204 0.55 6.19 0.32 1.77e-9 Diastolic blood pressure; CRC cis rs736801 0.780 rs12521868 chr5:131784393 A/C cg11843238 chr5:131593191 PDLIM4 -0.32 -5.63 -0.3 3.9e-8 Breast cancer;Mosquito bite size; CRC cis rs4363385 0.818 rs4576617 chr1:152985729 G/A cg25856811 chr1:152973957 SPRR3 -0.24 -6.71 -0.35 8.61e-11 Inflammatory skin disease; CRC cis rs708547 0.836 rs1277287 chr4:57853147 C/G cg25525207 chr4:57843836 C4orf14;POLR2B -0.58 -8.1 -0.41 1.07e-14 Response to bleomycin (chromatid breaks); CRC cis rs3018066 0.720 rs7662592 chr4:107004079 G/A cg01869342 chr4:106983673 TBCK 0.46 6.79 0.35 5.15e-11 Cancer; CRC cis rs12692738 0.526 rs422265 chr2:165630796 C/T cg03182029 chr2:165697222 COBLL1 0.51 6.07 0.32 3.46e-9 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);Waist-to-hip ratio adjusted for BMI in non-smokers;Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction);Waist-to-hip ratio adjusted for body mass index; CRC cis rs968567 0.817 rs61896141 chr11:61556039 A/C cg06781209 chr11:61594997 FADS2 -0.76 -9.24 -0.45 3.13e-18 Blood metabolite levels;Rheumatoid arthritis;Vitiligo;Glycerophospholipid levels; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg15005908 chr6:114292723 HDAC2 0.36 6.21 0.32 1.59e-9 Liver disease severity in Alagille syndrome; CRC cis rs12545109 0.800 rs1440762 chr8:57410708 C/T cg09654669 chr8:57350985 NA -0.47 -7.57 -0.39 3.78e-13 Obesity-related traits; CRC cis rs6951245 1.000 rs77305932 chr7:1100861 T/A cg20603222 chr7:1096387 C7orf50;GPR146 -0.72 -8.66 -0.43 2.19e-16 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs801193 0.613 rs2659900 chr7:66184443 G/C cg18876405 chr7:65276391 NA 0.5 8.31 0.42 2.49e-15 Aortic root size; CRC cis rs3749237 0.595 rs4855864 chr3:49521974 C/T cg03060546 chr3:49711283 APEH 0.62 10.4 0.5 4.44e-22 Resting heart rate; CRC cis rs1538970 0.924 rs10890327 chr1:45891458 C/T cg05343316 chr1:45956843 TESK2 0.74 10.05 0.48 6.51e-21 Platelet count; CRC cis rs7044106 0.791 rs10739572 chr9:123489815 C/T cg09419670 chr9:123605666 PSMD5;LOC253039 0.76 12.37 0.56 4.01e-29 Hip circumference adjusted for BMI; CRC trans rs3960554 0.800 rs80002395 chr7:75814902 C/T cg19862616 chr7:65841803 NCRNA00174 0.65 7.48 0.38 6.7e-13 Eotaxin levels; CRC cis rs4237845 1.000 rs4237845 chr12:58302436 A/G cg00677455 chr12:58241039 CTDSP2 -0.5 -7.69 -0.39 1.68e-13 Intelligence (multi-trait analysis); CRC cis rs7937682 0.575 rs34888817 chr11:111756455 C/T cg09085632 chr11:111637200 PPP2R1B 0.94 15.45 0.65 7.21e-41 Primary sclerosing cholangitis; CRC cis rs67311347 0.826 rs9863679 chr3:40439614 G/A cg09455208 chr3:40491958 NA 0.46 8.66 0.43 2.2e-16 Renal cell carcinoma; CRC cis rs727505 1.000 rs28392553 chr7:124442944 C/T cg23710748 chr7:124431027 NA -0.68 -11.92 -0.55 1.83e-27 Lewy body disease; CRC cis rs7726839 0.561 rs4957050 chr5:579066 A/C cg16447950 chr5:562315 NA -0.85 -12.55 -0.57 8.97e-30 Obesity-related traits; CRC cis rs3859192 0.561 rs34453912 chr17:38180352 T/A cg17344932 chr17:38183730 MED24;SNORD124 0.87 17.43 0.69 1.19e-48 White blood cell count; CRC cis rs875971 1.000 rs1182882 chr7:65562063 C/T cg11764359 chr7:65958608 NA -0.6 -9.59 -0.47 2.34e-19 Aortic root size; CRC cis rs4243830 0.737 rs925744 chr1:6615695 C/T cg22792644 chr1:6614718 TAS1R1;NOL9 -0.77 -9.26 -0.45 2.73e-18 Body mass index; CRC trans rs1814175 0.676 rs1851859 chr11:49860405 A/T cg03929089 chr4:120376271 NA -0.91 -15.75 -0.66 4.73e-42 Height; CRC cis rs2032447 0.899 rs1090947 chr6:26076642 T/C cg03517284 chr6:25882590 NA -0.48 -6.6 -0.34 1.67e-10 Intelligence (multi-trait analysis); CRC cis rs11997175 0.574 rs10954931 chr8:33631066 A/T cg04338863 chr8:33670619 NA 0.38 6.49 0.34 3.15e-10 Body mass index; CRC cis rs10540 1.000 rs61877775 chr11:521462 C/T cg19913688 chr11:428466 ANO9 -0.68 -6.56 -0.34 2.03e-10 Body mass index; CRC cis rs13256369 0.774 rs13260303 chr8:8587342 A/C cg06671706 chr8:8559999 CLDN23 0.51 7.46 0.38 7.94e-13 Obesity-related traits; CRC cis rs72627123 0.867 rs11848920 chr14:74476866 A/G cg12022184 chr14:74485813 ENTPD5;C14orf45 0.72 6.19 0.32 1.8e-9 Morning vs. evening chronotype; CRC cis rs910187 0.678 rs1046664 chr20:45817223 G/A cg27589058 chr20:45804311 EYA2 -0.4 -7.63 -0.39 2.53e-13 Migraine; CRC cis rs7726839 0.540 rs72703095 chr5:601789 T/C cg17948913 chr5:572064 NA 0.52 5.94 0.31 7.29e-9 Obesity-related traits; CRC cis rs6499255 1.000 rs4580150 chr16:69814953 G/A cg15192750 chr16:69999425 NA 0.58 7.46 0.38 7.89e-13 IgE levels; CRC trans rs7395662 0.611 rs7478698 chr11:48549139 T/C cg21153622 chr11:89784906 NA -0.51 -8.52 -0.43 5.87e-16 HDL cholesterol; CRC cis rs7208859 0.623 rs55961983 chr17:29119286 G/A cg13385521 chr17:29058706 SUZ12P 0.73 8.38 0.42 1.53e-15 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg00322946 chr10:22605631 COMMD3 0.42 5.97 0.31 6.27e-9 Response to antipsychotic treatment; CRC cis rs10876993 0.928 rs1678540 chr12:58065002 A/G cg18357645 chr12:58087776 OS9 0.59 8.19 0.41 5.82e-15 Celiac disease or Rheumatoid arthritis; CRC cis rs7799006 0.606 rs7792045 chr7:2316852 C/T cg08027265 chr7:2291960 NA -0.45 -7.71 -0.39 1.5e-13 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs995000 0.899 rs1305520 chr1:62926057 A/T cg19896129 chr1:63156450 NA -0.38 -5.91 -0.31 8.34e-9 Triglyceride levels; CRC cis rs66887589 0.592 rs2175383 chr4:120215836 C/A cg09307838 chr4:120376055 NA 0.55 8.45 0.42 9.3e-16 Diastolic blood pressure; CRC cis rs34779708 0.966 rs2505639 chr10:35474421 A/G cg03585969 chr10:35415529 CREM -0.52 -6.96 -0.36 1.83e-11 Inflammatory bowel disease;Crohn's disease; CRC cis rs12325245 0.536 rs3169293 chr16:58552959 A/G cg26666090 chr16:58549219 SETD6 0.94 6.4 0.33 5.36e-10 Schizophrenia; CRC cis rs3617 0.625 rs6445541 chr3:52880128 G/T cg07507251 chr3:52567010 NT5DC2 0.4 5.98 0.31 5.9e-9 Red blood cell count;Autism spectrum disorder or schizophrenia; CRC cis rs9611565 0.592 rs5996038 chr22:41965300 T/C cg06634786 chr22:41940651 POLR3H -0.53 -6.19 -0.32 1.74e-9 Vitiligo; CRC cis rs9292777 0.901 rs6878370 chr5:40433552 G/A cg09067459 chr5:40385259 NA 0.51 8.87 0.44 4.77e-17 Crohn's disease;Multiple sclerosis; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg04355093 chr4:85887382 WDFY3;C4orf12 0.39 6.45 0.34 3.92e-10 Liver disease severity in Alagille syndrome; CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg26462404 chr19:2270807 OAZ1 -0.5 -5.98 -0.31 5.66e-9 Diisocyanate-induced asthma; CRC cis rs28386778 1.000 rs28386778 chr17:61964815 T/C cg23090583 chr17:61904693 PSMC5;FTSJ3 1.02 17.84 0.7 2.77e-50 Prudent dietary pattern; CRC cis rs1153858 1.000 rs8042786 chr15:45703539 T/C cg10760299 chr15:45669010 GATM 0.52 7.94 0.4 3.27e-14 Homoarginine levels; CRC cis rs78456975 0.527 rs11885279 chr2:1560633 T/C cg12573674 chr2:1569213 NA -0.82 -10.49 -0.5 2.08e-22 Placebo response in major depressive disorder (% change in symptom score); CRC trans rs1814175 0.817 rs1988416 chr11:49932324 G/A cg03929089 chr4:120376271 NA -0.98 -19.27 -0.73 6.62e-56 Height; CRC cis rs2075371 0.796 rs12672752 chr7:134007382 C/T cg02659138 chr7:134003124 SLC35B4 0.41 7.2 0.37 4.14e-12 Mean platelet volume; CRC cis rs4713118 0.955 rs9468200 chr6:27683063 T/A cg15786705 chr6:28176104 NA 0.49 6.44 0.33 4.26e-10 Parkinson's disease; CRC cis rs9807989 0.507 rs1420096 chr2:103010912 C/T cg03938978 chr2:103052716 IL18RAP 0.59 10.18 0.49 2.44e-21 Asthma; CRC trans rs3942852 0.568 rs6485807 chr11:48102867 G/A cg15704280 chr7:45808275 SEPT13 -0.68 -9.8 -0.48 4.52e-20 Acute lymphoblastic leukemia (childhood); CRC cis rs28386778 0.897 rs7221853 chr17:61859836 A/G cg11494091 chr17:61959527 GH2 0.62 10.57 0.5 1.11e-22 Prudent dietary pattern; CRC cis rs17767392 1.000 rs34674149 chr14:71777093 C/A cg13720639 chr14:72061746 SIPA1L1 -0.54 -6.9 -0.36 2.71e-11 Mitral valve prolapse; CRC cis rs9649465 1.000 rs56396297 chr7:123350535 T/C cg03229431 chr7:123269106 ASB15 -0.36 -5.62 -0.3 4.05e-8 Migraine; CRC cis rs10870270 0.956 rs10870293 chr10:133771413 G/A cg17892150 chr10:133769511 PPP2R2D -0.75 -11.0 -0.52 3.58e-24 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; CRC cis rs887829 0.570 rs6736743 chr2:234595950 G/A cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.46 -7.13 -0.37 6.28e-12 Metabolic traits;Bilirubin levels;Cholelithiasis-related traits in sickle cell anemia;Metabolite levels;Total bilirubin levels in HIV-1 infection;Serum metabolite levels;Blood metabolite levels; CRC cis rs9894429 0.690 rs12949956 chr17:79542813 C/T cg18240062 chr17:79603768 NPLOC4 -0.68 -11.89 -0.55 2.39e-27 Eye color traits; CRC cis rs10504229 0.636 rs72649133 chr8:58054681 G/A cg24829409 chr8:58192753 C8orf71 -0.68 -8.25 -0.41 3.95e-15 Developmental language disorder (linguistic errors); CRC cis rs4862750 0.914 rs6814259 chr4:187872337 T/C cg10295955 chr4:187884368 NA -1.0 -22.68 -0.78 3.05e-69 Lobe attachment (rater-scored or self-reported); CRC cis rs6461049 0.766 rs10256077 chr7:2171450 C/T cg02951883 chr7:2050386 MAD1L1 0.52 8.39 0.42 1.49e-15 Schizophrenia; CRC cis rs10540 1.000 rs35068485 chr11:466032 A/T cg08200582 chr11:442649 ANO9 -0.69 -7.21 -0.37 3.75e-12 Body mass index; CRC cis rs7615952 0.546 rs11718647 chr3:125352022 G/A cg11143507 chr3:125485238 NA -0.52 -5.71 -0.3 2.53e-8 Blood pressure (smoking interaction); CRC cis rs10540 1.000 rs35811812 chr11:498442 G/A cg08200582 chr11:442649 ANO9 -0.68 -7.65 -0.39 2.26e-13 Body mass index; CRC cis rs2180341 0.618 rs12210968 chr6:127596985 A/G cg24812749 chr6:127587940 RNF146 0.63 9.41 0.46 8.71e-19 Breast cancer; CRC cis rs7945705 0.967 rs34842234 chr11:8891894 G/A cg14711859 chr11:8959438 ASCL3 -0.51 -8.24 -0.41 4.27e-15 Hemoglobin concentration; CRC cis rs10512697 0.764 rs13155882 chr5:3543787 C/G cg19473799 chr5:3511975 NA -0.77 -5.97 -0.31 6.25e-9 Immune response to smallpox vaccine (IL-6); CRC cis rs11671005 0.695 rs8106061 chr19:58917990 G/C cg00825309 chr19:58991885 ZNF446 -0.88 -14.26 -0.62 2.94e-36 Mean platelet volume; CRC trans rs2727020 0.638 rs1164668 chr11:49330627 A/C cg15704280 chr7:45808275 SEPT13 0.88 15.73 0.66 5.92e-42 Coronary artery disease; CRC cis rs2243480 1.000 rs316321 chr7:65611613 G/A cg18252515 chr7:66147081 NA -1.26 -14.48 -0.62 4.06e-37 Diabetic kidney disease; CRC cis rs832540 1.000 rs252914 chr5:56198150 A/C cg12311346 chr5:56204834 C5orf35 -0.45 -6.72 -0.35 7.99e-11 Coronary artery disease; CRC cis rs3859192 0.561 rs12451547 chr17:38181168 T/C cg17467752 chr17:38218738 THRA -0.51 -7.48 -0.38 7.02e-13 White blood cell count; CRC cis rs9894429 0.646 rs8080391 chr17:79566319 A/T cg21028142 chr17:79581711 NPLOC4 -0.33 -7.05 -0.36 1.09e-11 Eye color traits; CRC cis rs10504229 0.683 rs11786523 chr8:58131319 G/C cg05313129 chr8:58192883 C8orf71 -0.43 -6.11 -0.32 2.74e-9 Developmental language disorder (linguistic errors); CRC trans rs9784649 0.882 rs2201296 chr5:24967119 G/A cg08600765 chr20:34638493 LOC647979 -0.59 -7.27 -0.37 2.69e-12 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs801193 0.636 rs10233806 chr7:66118248 G/C cg00343986 chr7:65444356 GUSB -0.44 -6.3 -0.33 9.77e-10 Aortic root size; CRC cis rs910316 0.763 rs175014 chr14:75456927 A/G cg03030879 chr14:75389066 RPS6KL1 0.4 5.94 0.31 7.17e-9 Height; CRC cis rs34787248 1 rs34787248 chr6:28197886 C/T cg15845792 chr6:28175446 NA 0.78 8.35 0.42 1.98e-15 Autism spectrum disorder or schizophrenia; CRC cis rs11587400 0.514 rs222499 chr1:115146488 C/A cg12756093 chr1:115239321 AMPD1 -0.44 -5.97 -0.31 6.06e-9 Autism; CRC trans rs944990 0.595 rs10123378 chr9:96375217 C/T cg00222291 chr16:22385662 CDR2 0.42 6.11 0.32 2.77e-9 Body mass index; CRC cis rs6961069 0.777 rs1953299 chr7:80265625 T/G cg04458919 chr7:80252533 CD36 0.33 5.87 0.31 1.06e-8 Platelet count; CRC cis rs6738485 0.763 rs11681976 chr2:106841591 C/A cg16099169 chr2:106886729 NA -0.39 -6.78 -0.35 5.5e-11 Pursuit maintenance gain;Pursuit maintenance gain in psychotic disorders; CRC cis rs1949733 1.000 rs2688223 chr4:8471398 T/C cg13073564 chr4:8508604 NA -0.5 -7.45 -0.38 8.26e-13 Response to antineoplastic agents; CRC cis rs55882075 0.690 rs12374485 chr5:179131395 G/C cg14593053 chr5:179126677 CANX 0.5 7.78 0.39 9.2e-14 Monocyte percentage of white cells; CRC cis rs1044826 0.642 rs6784684 chr3:139177634 T/C cg00490450 chr3:139108681 COPB2 0.45 6.65 0.34 1.19e-10 Obesity-related traits; CRC cis rs10463316 0.817 rs2112419 chr5:150797804 T/C cg03212797 chr5:150827313 SLC36A1 -0.51 -7.82 -0.4 7.14e-14 Metabolite levels (Pyroglutamine); CRC cis rs951366 0.903 rs823114 chr1:205719532 G/A cg24503407 chr1:205819492 PM20D1 0.51 7.63 0.39 2.5e-13 Menarche (age at onset); CRC cis rs2421770 0.530 rs3847621 chr11:35364435 G/A cg13971030 chr11:35366721 SLC1A2 -0.39 -6.75 -0.35 6.74e-11 Staphylococcus aureus nasal carriage (persistent); CRC cis rs1799949 1.000 rs34059614 chr17:41303071 C/T cg01879757 chr17:41196368 BRCA1 -0.42 -6.24 -0.33 1.31e-9 Menopause (age at onset); CRC cis rs727505 1.000 rs7801661 chr7:124483222 C/T cg23710748 chr7:124431027 NA 0.81 13.92 0.61 5.8e-35 Lewy body disease; CRC cis rs9534288 0.742 rs1977395 chr13:46638131 C/T cg15192986 chr13:46630673 CPB2 -0.72 -9.27 -0.46 2.47e-18 Blood protein levels; CRC cis rs6088580 0.634 rs6141471 chr20:33006730 A/G cg24642439 chr20:33292090 TP53INP2 -0.37 -6.36 -0.33 6.77e-10 Glomerular filtration rate (creatinine); CRC cis rs35110281 0.501 rs162378 chr21:44925905 A/G cg04455712 chr21:45112962 RRP1B -0.35 -6.08 -0.32 3.34e-9 Mean corpuscular volume; CRC cis rs929354 0.772 rs1002389 chr7:156968323 C/G cg05182265 chr7:156933206 UBE3C -0.75 -14.06 -0.61 1.78e-35 Body mass index; CRC cis rs1942 0.837 rs12440045 chr15:41782684 A/C cg18705301 chr15:41695430 NDUFAF1 -0.38 -6.22 -0.32 1.52e-9 Eosinophil percentage of granulocytes; CRC cis rs78456975 1.000 rs4073861 chr2:1563611 G/A cg26248373 chr2:1572462 NA -0.69 -7.52 -0.38 5.13e-13 Placebo response in major depressive disorder (% change in symptom score); CRC cis rs9322193 0.923 rs2297928 chr6:150039720 G/C cg07701084 chr6:150067640 NUP43 0.56 8.2 0.41 5.45e-15 Lung cancer; CRC cis rs17227506 0.679 rs34216318 chr8:13444780 T/C cg03566418 chr8:13424080 C8orf48 0.34 5.79 0.3 1.65e-8 Nonsyndromic cleft lip with cleft palate; CRC trans rs10982213 0.830 rs2274163 chr9:117188714 C/T cg03152577 chr1:54411898 LRRC42;HSPB11 0.42 6.66 0.34 1.13e-10 Interleukin-6 levels; CRC cis rs2274273 0.901 rs8011288 chr14:55735112 C/T cg10130446 chr14:55658398 DLGAP5 -0.39 -5.61 -0.3 4.23e-8 Protein biomarker; CRC cis rs6665290 0.935 rs11588904 chr1:227196211 T/C cg10327440 chr1:227177885 CDC42BPA -1.04 -23.33 -0.79 9.69e-72 Myeloid white cell count; CRC cis rs10540 1.000 rs79440439 chr11:478147 A/C cg03352830 chr11:487213 PTDSS2 0.65 6.84 0.35 3.8e-11 Body mass index; CRC trans rs1404872 0.717 rs73049436 chr7:3329350 T/C cg25123566 chr12:47610734 FAM113B;LOC100233209 -0.52 -6.0 -0.31 5.16e-9 Facial morphology (factor 5, width of mouth relative to central midface); CRC cis rs7666738 0.830 rs17483521 chr4:98974058 A/T cg05340658 chr4:99064831 C4orf37 0.59 9.17 0.45 5.34e-18 Colonoscopy-negative controls vs population controls; CRC cis rs1552244 0.882 rs68153882 chr3:10013110 T/C cg02579736 chr3:10068473 FANCD2;CIDECP 0.93 12.04 0.55 6.82e-28 Alzheimer's disease; CRC cis rs5769707 0.616 rs135869 chr22:50008366 T/C cg20744362 chr22:50050164 C22orf34 0.34 5.98 0.31 5.93e-9 Monocyte count;Monocyte percentage of white cells; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg04857149 chr18:24237060 NA 0.44 6.73 0.35 7.4e-11 Liver disease severity in Alagille syndrome; CRC cis rs9811920 0.599 rs61148087 chr3:99539891 C/A cg08350549 chr3:99591722 C3orf26;FILIP1L;MIR548G -0.36 -5.62 -0.3 4.13e-8 Axial length; CRC cis rs28386778 0.897 rs8081454 chr17:61842646 A/G cg23090583 chr17:61904693 PSMC5;FTSJ3 1.05 20.23 0.74 1.07e-59 Prudent dietary pattern; CRC trans rs1814175 0.817 rs10839351 chr11:49758153 C/T cg15704280 chr7:45808275 SEPT13 -1.0 -20.12 -0.74 2.91e-59 Height; CRC cis rs7618915 1.000 rs3852063 chr3:52349204 A/G cg14092988 chr3:52407081 DNAH1 0.39 7.07 0.36 9.58e-12 Bipolar disorder; CRC cis rs943466 0.614 rs4713677 chr6:33731225 C/G cg25922239 chr6:33757077 LEMD2 -0.39 -5.8 -0.3 1.54e-8 Body mass index (joint analysis main effects and physical activity interaction);Body mass index; CRC cis rs7605827 0.930 rs9287660 chr2:15595767 C/A cg19274914 chr2:15703543 NA 0.4 6.04 0.32 4.18e-9 Educational attainment (years of education); CRC cis rs6952808 0.717 rs10950422 chr7:1926577 T/C cg20295408 chr7:1910781 MAD1L1 -0.37 -5.74 -0.3 2.1e-8 Bipolar disorder and schizophrenia; CRC cis rs1577917 1.000 rs35797755 chr6:86706554 A/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.54 -6.95 -0.36 2.02e-11 Response to antipsychotic treatment; CRC cis rs7412746 0.658 rs72704682 chr1:150897677 A/T cg18016565 chr1:150552671 MCL1 0.42 6.06 0.32 3.63e-9 Melanoma; CRC cis rs6076065 0.748 rs2295239 chr20:23387550 C/T cg11657817 chr20:23433608 CST11 0.54 9.27 0.46 2.55e-18 Facial morphology (factor 15, philtrum width); CRC cis rs7949030 0.596 rs11231137 chr11:62315699 G/A cg22862634 chr11:62369728 EML3;MTA2 0.56 8.85 0.44 5.4e-17 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; CRC cis rs7953249 0.656 rs6489786 chr12:121397875 A/G cg02403541 chr12:121454288 C12orf43 -0.42 -6.04 -0.32 4.22e-9 Invasive epithelial ovarian cancer;High-grade serous ovarian cancer;Chronic obstructive pulmonary disease-related biomarkers;N-glycan levels;Serous invasive ovarian cancer;Epithelial ovarian cancer; CRC cis rs1707322 1.000 rs11211217 chr1:46348229 C/G cg03146154 chr1:46216737 IPP 0.51 7.1 0.36 7.52e-12 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs7927592 0.731 rs7108376 chr11:68347870 A/G cg01657329 chr11:68192670 LRP5 0.57 9.43 0.46 7.8e-19 Total body bone mineral density; CRC cis rs763121 0.853 rs2235230 chr22:39124467 A/G cg06022373 chr22:39101656 GTPBP1 -0.74 -10.91 -0.52 7.56e-24 Menopause (age at onset); CRC cis rs236352 0.515 rs9380610 chr6:36805885 A/C cg10099585 chr6:36853529 C6orf89 -0.43 -6.27 -0.33 1.12e-9 Heart rate; CRC cis rs514406 0.644 rs7552663 chr1:53204352 C/T cg24675658 chr1:53192096 ZYG11B 0.72 11.92 0.55 1.85e-27 Monocyte count; CRC cis rs2688608 0.618 rs28718766 chr10:75489844 C/A cg23231163 chr10:75533350 FUT11 -0.37 -5.64 -0.3 3.64e-8 Inflammatory bowel disease; CRC cis rs7124681 0.584 rs1471712 chr11:47912150 G/A cg20307385 chr11:47447363 PSMC3 -0.49 -7.19 -0.37 4.29e-12 Body mass index (joint analysis main effects and physical activity interaction);Body mass index;Body mass index in physically active individuals; CRC cis rs25645 0.502 rs7209742 chr17:38108708 A/G cg24910161 chr17:38119198 GSDMA -0.36 -5.94 -0.31 7.28e-9 Myeloid white cell count; CRC cis rs354033 1.000 rs56707870 chr7:149265728 T/C cg24335155 chr7:149193227 ZNF746 0.37 5.7 0.3 2.64e-8 Multiple sclerosis; CRC trans rs7944735 0.507 rs7934659 chr11:48066374 C/T cg15704280 chr7:45808275 SEPT13 0.58 7.96 0.4 2.77e-14 Intraocular pressure; CRC cis rs7412746 0.658 rs7526489 chr1:150726238 C/T cg17724175 chr1:150552817 MCL1 0.5 7.33 0.37 1.83e-12 Melanoma; CRC cis rs4665809 1.000 rs750452 chr2:26324995 G/A cg27170947 chr2:26402098 FAM59B -0.46 -6.1 -0.32 2.93e-9 Gut microbiome composition (summer); CRC cis rs11645898 0.935 rs72787078 chr16:72158493 C/T cg14768367 chr16:72042858 DHODH -0.6 -6.78 -0.35 5.49e-11 Blood protein levels; CRC cis rs10504229 0.724 rs58715581 chr8:58134568 A/G cg02725872 chr8:58115012 NA -0.64 -11.55 -0.54 3.85e-26 Developmental language disorder (linguistic errors); CRC cis rs17401966 0.838 rs2182326 chr1:10385664 G/A cg19773385 chr1:10388646 KIF1B -0.64 -10.4 -0.5 4.3e-22 Hepatocellular carcinoma; CRC cis rs6484504 0.576 rs158140 chr11:31212971 T/C cg14844989 chr11:31128820 NA -0.34 -6.04 -0.32 4.06e-9 Red blood cell count; CRC cis rs4713118 0.662 rs149970 chr6:27980220 C/T cg20615401 chr6:28092323 ZSCAN16 0.47 5.9 0.31 9.13e-9 Parkinson's disease; CRC cis rs11229555 0.645 rs4594017 chr11:58194788 T/C cg15696309 chr11:58395628 NA -0.82 -10.45 -0.5 2.81e-22 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; CRC cis rs4423214 1.000 rs3750997 chr11:71158841 A/C cg05163923 chr11:71159392 DHCR7 0.62 8.82 0.44 6.82e-17 Vitamin D levels; CRC cis rs2228479 0.850 rs17226980 chr16:89825065 G/A cg06656553 chr16:89960601 TCF25 -0.7 -5.76 -0.3 1.93e-8 Skin colour saturation; CRC cis rs6968419 0.714 rs7811984 chr7:115886079 A/G cg02561103 chr7:115862891 TES -0.42 -6.31 -0.33 8.9e-10 Intraocular pressure; CRC cis rs3820068 0.603 rs72647138 chr1:15980929 C/T cg13390004 chr1:15929781 NA 0.53 7.43 0.38 9.43e-13 Systolic blood pressure; CRC cis rs4954585 0.683 rs13024450 chr2:137014611 C/T cg05194412 chr2:137003533 NA 0.44 6.84 0.35 3.76e-11 Colorectal cancer; CRC cis rs6076065 0.723 rs2424539 chr20:23384904 C/T cg11657817 chr20:23433608 CST11 -0.4 -5.89 -0.31 9.33e-9 Facial morphology (factor 15, philtrum width); CRC cis rs6963495 0.818 rs73192105 chr7:105167945 T/C cg13798780 chr7:105162888 PUS7 0.67 7.97 0.4 2.72e-14 Bipolar disorder (body mass index interaction); CRC cis rs2228479 0.850 rs17233455 chr16:89816407 A/G cg06558623 chr16:89946397 TCF25 1.15 10.8 0.51 1.85e-23 Skin colour saturation; CRC cis rs12325245 0.536 rs34161389 chr16:58622604 G/A cg26666090 chr16:58549219 SETD6 0.94 6.49 0.34 3.19e-10 Schizophrenia; CRC cis rs7932354 0.583 rs7107778 chr11:46860855 C/T cg19486271 chr11:47235900 DDB2 -0.44 -6.62 -0.34 1.45e-10 Bone mineral density (hip);Bone mineral density; CRC cis rs9494145 0.531 rs9399136 chr6:135402339 T/C cg22676075 chr6:135203613 NA 0.61 7.85 0.4 5.94e-14 Mean platelet volume;Platelet count;Fetal hemoglobin levels in sickle cell anemia;Red blood cell traits; CRC cis rs12024301 0.557 rs75344054 chr1:183598479 T/A cg11505048 chr1:183622726 RGL1;APOBEC4 0.76 6.93 0.36 2.16e-11 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs6061231 0.793 rs2427320 chr20:60976723 A/G cg24112000 chr20:60950667 NA -0.6 -9.29 -0.46 2.12e-18 Colorectal cancer; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg17373656 chr21:45196239 CSTB 0.44 6.22 0.32 1.51e-9 Anxiety disorder; CRC cis rs939574 1.000 rs11552796 chr2:220108300 T/C cg00496455 chr2:220118770 TUBA4A;TUBA4B 0.91 9.61 0.47 1.99e-19 Platelet distribution width; CRC cis rs10504229 1.000 rs67895971 chr8:58177994 A/G cg02725872 chr8:58115012 NA -0.38 -6.43 -0.33 4.44e-10 Developmental language disorder (linguistic errors); CRC trans rs8073060 0.586 rs225298 chr17:33923946 T/G cg19694781 chr19:47549865 TMEM160 -1.06 -15.38 -0.65 1.35e-40 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; CRC cis rs6121246 0.909 rs6060960 chr20:30394517 G/T cg18721089 chr20:30220636 NA 0.35 5.77 0.3 1.82e-8 Mean corpuscular hemoglobin; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg20946600 chr2:27294721 LOC100128731 0.51 6.91 0.36 2.56e-11 Anxiety disorder; CRC cis rs73206853 0.620 rs17682482 chr12:111154788 C/G cg12870014 chr12:110450643 ANKRD13A 0.74 6.8 0.35 5.04e-11 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC trans rs7937682 0.921 rs4616071 chr11:111440865 C/G cg18187862 chr3:45730750 SACM1L -0.52 -6.88 -0.35 3.12e-11 Primary sclerosing cholangitis; CRC cis rs1707322 0.928 rs925524 chr1:46496709 A/G cg03146154 chr1:46216737 IPP -0.51 -7.04 -0.36 1.11e-11 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs7811142 1.000 rs4989959 chr7:100032288 T/C cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.74 10.2 0.49 2.05e-21 Platelet count; CRC cis rs1552244 0.510 rs13075308 chr3:10034925 G/C cg10729496 chr3:10149963 C3orf24 0.49 6.34 0.33 7.69e-10 Alzheimer's disease; CRC cis rs12760731 0.565 rs7541122 chr1:178199214 G/C cg00404053 chr1:178313656 RASAL2 1.05 10.89 0.51 8.62e-24 Obesity-related traits; CRC cis rs2976388 0.556 rs10956985 chr8:143818750 C/A cg05569086 chr8:143859399 LYNX1 -0.4 -6.12 -0.32 2.59e-9 Urinary tract infection frequency; CRC trans rs7937682 0.824 rs577044 chr11:111490420 G/T cg18187862 chr3:45730750 SACM1L 0.46 6.7 0.35 9.15e-11 Primary sclerosing cholangitis; CRC cis rs2952156 0.883 rs907089 chr17:37833600 C/T cg11212589 chr17:38028394 ZPBP2 0.33 5.92 0.31 8.01e-9 Asthma; CRC cis rs7615952 0.641 rs12495947 chr3:125771698 C/T cg06494592 chr3:125709126 NA -0.56 -6.73 -0.35 7.33e-11 Blood pressure (smoking interaction); CRC cis rs755249 0.530 rs16826087 chr1:39812518 C/T cg18385671 chr1:39797026 MACF1 -0.41 -5.77 -0.3 1.81e-8 Peripheral arterial disease (traffic-related air pollution interaction); CRC trans rs6703335 0.870 rs10803142 chr1:243598234 A/G cg17076921 chr10:75634595 CAMK2G 0.42 6.09 0.32 3.18e-9 Schizophrenia;Schizophrenia, schizoaffective disorder or bipolar disorder; CRC cis rs796364 0.806 rs74266489 chr2:201005732 G/A cg25936922 chr2:200820526 C2orf60;C2orf47 -0.65 -6.15 -0.32 2.23e-9 Schizophrenia; CRC cis rs806794 1.000 rs806794 chr6:26200677 A/G cg00631329 chr6:26305371 NA -0.42 -6.94 -0.36 2.03e-11 Waist circumference;Hip circumference adjusted for BMI;Waist circumference adjusted for body mass index;Hip circumference;Height;Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction);Waist circumference adjusted for BMI in active individuals; CRC cis rs4478858 0.735 rs1566963 chr1:31772206 G/A cg00250761 chr1:31883323 NA -0.42 -8.2 -0.41 5.51e-15 Alcohol dependence; CRC cis rs10982256 0.774 rs13286280 chr9:117246504 C/T cg13636371 chr9:117264095 DFNB31 0.33 6.39 0.33 5.67e-10 Bipolar disorder; CRC cis rs11249608 0.600 rs6859767 chr5:178451107 T/C cg01312482 chr5:178451176 ZNF879 -0.36 -6.0 -0.31 5.09e-9 Pubertal anthropometrics; CRC cis rs7662987 0.517 rs1453874 chr4:100022724 G/A cg13256891 chr4:100009986 ADH5 0.63 8.56 0.43 4.54e-16 Smoking initiation; CRC cis rs1656402 1.000 rs6761056 chr2:233437045 T/A cg03852847 chr2:233439513 NA -0.44 -7.51 -0.38 5.71e-13 Non-small cell lung cancer (survival); CRC cis rs116095464 0.558 rs7708182 chr5:234788 C/G cg22857025 chr5:266934 NA -1.25 -16.75 -0.68 5.7e-46 Breast cancer; CRC cis rs1348850 1.000 rs1348850 chr2:178418575 A/G cg02961200 chr2:178257176 LOC100130691;AGPS 0.57 8.27 0.41 3.45e-15 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC trans rs2553218 0.690 rs8032415 chr15:54851945 A/G cg07028284 chr17:4871281 SPAG7 0.44 6.11 0.32 2.74e-9 Immune response to smallpox vaccine (IL-6); CRC cis rs10865541 0.934 rs4627605 chr2:3411923 G/A cg22182287 chr2:3452347 TTC15 0.39 6.07 0.32 3.57e-9 Obesity-related traits; CRC cis rs9311474 0.508 rs7614498 chr3:52618941 A/T cg15147215 chr3:52552868 STAB1 -0.64 -11.04 -0.52 2.62e-24 Electroencephalogram traits; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg27309920 chr12:6798957 ZNF384 0.5 6.66 0.34 1.16e-10 Thyroid stimulating hormone; CRC cis rs7580658 0.724 rs6712213 chr2:127998230 G/A cg09760422 chr2:128146352 NA -0.36 -6.94 -0.36 2.05e-11 Protein C levels; CRC cis rs17270561 0.609 rs9379785 chr6:25726213 G/A cg17691542 chr6:26056736 HIST1H1C 0.72 9.21 0.45 3.86e-18 Iron status biomarkers; CRC cis rs9311474 0.508 rs7625743 chr3:52606366 C/G cg08222913 chr3:52553049 STAB1 -0.34 -6.39 -0.33 5.78e-10 Electroencephalogram traits; CRC cis rs2239547 0.522 rs9844736 chr3:52931971 T/G cg18404041 chr3:52824283 ITIH1 0.36 6.63 0.34 1.38e-10 Schizophrenia; CRC cis rs780096 0.546 rs12473776 chr2:27636474 A/G cg21248554 chr2:27665150 KRTCAP3 -0.32 -7.39 -0.38 1.22e-12 Total body bone mineral density; CRC cis rs2108622 0.727 rs8104311 chr19:15982760 T/C cg13772218 chr19:15982569 NA 0.49 7.01 0.36 1.39e-11 Circulating phylloquinone levels;Vitamin E levels;Acenocoumarol maintenance dosage;Response to Vitamin E supplementation;Metabolite levels;Warfarin maintenance dose; CRC cis rs995000 0.826 rs7555577 chr1:63034363 A/C cg19896129 chr1:63156450 NA -0.44 -6.81 -0.35 4.73e-11 Triglyceride levels; CRC cis rs1552244 1.000 rs7637888 chr3:10080722 T/C cg08888203 chr3:10149979 C3orf24 0.73 10.08 0.49 5.45e-21 Alzheimer's disease; CRC cis rs10927875 0.722 rs1763606 chr1:16338282 A/G cg21385522 chr1:16154831 NA 0.61 7.68 0.39 1.85e-13 Dilated cardiomyopathy; CRC cis rs72781680 0.898 rs72796158 chr2:23935727 T/C cg08917208 chr2:24149416 ATAD2B 0.99 9.37 0.46 1.21e-18 Lymphocyte counts; CRC cis rs6681460 0.966 rs7519747 chr1:67140723 T/C cg02459107 chr1:67143332 SGIP1 0.5 8.84 0.44 6.04e-17 Presence of antiphospholipid antibodies; CRC cis rs754466 0.561 rs11002343 chr10:79705871 G/A cg17075019 chr10:79541650 NA -0.61 -6.82 -0.35 4.31e-11 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs6933660 0.646 rs9397051 chr6:151778325 C/T cg10883421 chr6:151773342 RMND1;C6orf211 0.81 14.91 0.63 9.46e-39 Menarche (age at onset); CRC cis rs59104589 0.583 rs62186399 chr2:242225325 G/C cg19488206 chr2:242435732 STK25 0.49 6.91 0.36 2.45e-11 Fibrinogen levels; CRC cis rs7666738 0.830 rs13147768 chr4:98833675 A/T cg05340658 chr4:99064831 C4orf37 0.53 7.69 0.39 1.73e-13 Colonoscopy-negative controls vs population controls; CRC cis rs4481887 0.927 rs4347240 chr1:248475403 C/G cg00666640 chr1:248458726 OR2T12 0.47 8.07 0.41 1.36e-14 Common traits (Other); CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg17738503 chr17:49244158 NME2;NME1-NME2 0.37 6.02 0.31 4.58e-9 Obesity-related traits; CRC cis rs2404602 0.583 rs2456076 chr15:76557553 T/G cg03037974 chr15:76606532 NA -0.75 -14.36 -0.62 1.27e-36 Blood metabolite levels; CRC cis rs896854 0.654 rs4735339 chr8:95974373 C/T cg13393036 chr8:95962371 TP53INP1 -0.54 -9.27 -0.46 2.49e-18 Type 2 diabetes; CRC cis rs6921919 0.583 rs6922429 chr6:28381345 T/C cg21251018 chr6:28226885 NKAPL 0.39 5.93 0.31 7.61e-9 Autism spectrum disorder or schizophrenia; CRC cis rs4988958 0.527 rs6756161 chr2:103048417 C/A cg03938978 chr2:103052716 IL18RAP 0.59 10.09 0.49 4.8e-21 Asthma (childhood onset); CRC cis rs1045714 0.895 rs61729413 chr7:2646796 G/A cg24848437 chr7:2645542 IQCE 0.59 6.27 0.33 1.17e-9 Urate levels in lean individuals; CRC cis rs8177253 0.763 rs6797713 chr3:133474832 T/C cg11941060 chr3:133502564 NA -0.56 -9.34 -0.46 1.51e-18 Iron status biomarkers; CRC cis rs4285028 0.747 rs58367397 chr3:121451700 A/G cg20356878 chr3:121714668 ILDR1 -0.42 -6.01 -0.31 5.02e-9 Multiple sclerosis; CRC cis rs12477438 0.501 rs11685756 chr2:99766215 T/C cg26064155 chr2:99771622 LIPT1;TSGA10 0.83 14.66 0.63 8.22e-38 Chronic sinus infection; CRC cis rs61160187 0.582 rs12516995 chr5:60308274 C/T cg16298547 chr5:60138761 ELOVL7 -0.26 -5.76 -0.3 1.88e-8 Educational attainment (years of education);Educational attainment (college completion); CRC cis rs28386778 0.897 rs2584642 chr17:61942427 T/C cg06601766 chr17:61851465 DDX42;CCDC47 0.43 5.83 0.31 1.33e-8 Prudent dietary pattern; CRC cis rs6933660 0.800 rs963193 chr6:151789355 G/T cg14262678 chr6:151773367 RMND1;C6orf211 -0.53 -9.0 -0.44 1.79e-17 Menarche (age at onset); CRC cis rs875971 0.792 rs6971752 chr7:65737986 G/A cg12463550 chr7:65579703 CRCP -0.53 -7.42 -0.38 9.97e-13 Aortic root size; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg14393411 chr19:13067586 GADD45GIP1 0.45 6.25 0.33 1.25e-9 Response to antipsychotic treatment; CRC cis rs9640161 0.789 rs2159234 chr7:150020422 A/T cg13722127 chr7:150037890 RARRES2 0.49 7.66 0.39 2.06e-13 Blood protein levels;Circulating chemerin levels; CRC cis rs5769765 0.819 rs9616379 chr22:50312035 C/T cg08270630 chr22:50330655 NA -0.4 -5.62 -0.3 4.04e-8 Schizophrenia; CRC cis rs35306767 0.501 rs4880763 chr10:1147045 G/A cg26597838 chr10:835615 NA 0.73 8.13 0.41 9.08e-15 Eosinophil percentage of granulocytes; CRC cis rs7707921 1.000 rs7707921 chr5:81538046 T/A cg17942617 chr5:81327376 ATG10 -0.38 -5.78 -0.3 1.76e-8 Breast cancer; CRC cis rs4713118 0.539 rs200951 chr6:27835930 A/G cg23161317 chr6:28129485 ZNF389 0.43 6.03 0.32 4.45e-9 Parkinson's disease; CRC cis rs116095464 0.558 rs9687621 chr5:229194 C/T cg22496380 chr5:211416 CCDC127 -1.0 -9.95 -0.48 1.43e-20 Breast cancer; CRC cis rs4604732 0.588 rs7552461 chr1:247628644 G/A cg02104434 chr1:247694406 LOC148824;OR2C3 0.54 8.15 0.41 7.85e-15 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CRC cis rs17376456 0.825 rs28610997 chr5:93248374 T/C cg25358565 chr5:93447407 FAM172A 1.12 10.53 0.5 1.51e-22 Diabetic retinopathy; CRC cis rs6860806 0.507 rs272891 chr5:131664394 G/T cg02033258 chr5:131593261 PDLIM4 0.38 6.41 0.33 4.9e-10 Breast cancer; CRC cis rs6901250 0.851 rs7740481 chr6:117149307 G/C cg12892004 chr6:117198278 RFX6 0.45 7.07 0.36 9.6e-12 C-reactive protein levels; CRC cis rs950169 0.922 rs4586394 chr15:84822385 G/A cg11189052 chr15:85197271 WDR73 -0.64 -8.78 -0.44 8.95e-17 Schizophrenia; CRC cis rs62064224 0.554 rs9894877 chr17:30679517 T/A cg12855166 chr17:30846586 MYO1D -0.37 -6.0 -0.31 5.19e-9 Schizophrenia; CRC trans rs2303319 0.504 rs62187657 chr2:162488091 G/A cg25193742 chr10:104614220 C10orf32 -0.78 -6.16 -0.32 2.17e-9 Cognitive function; CRC cis rs6860806 0.507 rs183898 chr5:131716902 C/G cg02033258 chr5:131593261 PDLIM4 -0.38 -6.51 -0.34 2.86e-10 Breast cancer; CRC cis rs500492 0.508 rs2744147 chr16:1073146 C/G cg09791621 chr16:1078722 NA 0.45 6.12 0.32 2.7e-9 Polycystic ovary syndrome; CRC cis rs28386778 0.897 rs1982400 chr17:61793818 T/C cg22520471 chr17:61851767 DDX42;CCDC47 0.7 10.67 0.51 5.21e-23 Prudent dietary pattern; CRC cis rs10504229 1.000 rs73607863 chr8:58170178 A/G cg01721255 chr8:58191610 C8orf71 0.49 6.17 0.32 2e-9 Developmental language disorder (linguistic errors); CRC cis rs8036030 0.604 rs11856835 chr15:74716174 G/A cg14664628 chr15:75095509 CSK -0.46 -6.24 -0.33 1.38e-9 Airflow obstruction; CRC cis rs9388451 0.839 rs9321054 chr6:126079968 A/G cg05901451 chr6:126070800 HEY2 0.66 11.63 0.54 2.04e-26 Brugada syndrome; CRC cis rs950169 0.922 rs4842940 chr15:84831225 C/T cg17507749 chr15:85114479 UBE2QP1 -0.75 -11.08 -0.52 1.9e-24 Schizophrenia; CRC cis rs11148252 0.716 rs2760772 chr13:52780373 C/G cg02158880 chr13:53174818 NA 0.45 6.41 0.33 5.02e-10 Lewy body disease; CRC cis rs9649213 0.574 rs9648908 chr7:97945236 C/T cg24562669 chr7:97807699 LMTK2 0.42 7.03 0.36 1.18e-11 Prostate cancer (SNP x SNP interaction); CRC cis rs2249694 0.537 rs751945 chr10:135329939 G/A cg20169779 chr10:135381914 SYCE1 0.51 6.48 0.34 3.27e-10 Obesity-related traits; CRC cis rs758324 0.947 rs4705835 chr5:131116899 T/C cg06307176 chr5:131281290 NA 0.43 6.38 0.33 6.19e-10 Alzheimer's disease in APOE e4- carriers; CRC trans rs2303319 0.504 rs62189042 chr2:162602320 G/T cg23919916 chr10:103825097 HPS6 -0.69 -6.01 -0.31 4.8e-9 Cognitive function; CRC trans rs4689592 0.622 rs2276968 chr4:7070118 T/G cg07817883 chr1:32538562 TMEM39B -0.61 -7.14 -0.37 5.96e-12 Monocyte percentage of white cells; CRC cis rs4555082 0.874 rs2816625 chr14:105734565 G/A cg10792982 chr14:105748885 BRF1 0.38 6.28 0.33 1.08e-9 Mean platelet volume;Platelet distribution width; CRC cis rs6952808 0.698 rs11765639 chr7:1986738 G/A cg00106254 chr7:1943704 MAD1L1 -0.49 -6.66 -0.34 1.15e-10 Bipolar disorder and schizophrenia; CRC cis rs1865760 0.786 rs2164487 chr6:25950800 A/C cg16482183 chr6:26056742 HIST1H1C 0.55 7.99 0.4 2.25e-14 Height; CRC cis rs12142240 0.698 rs41534051 chr1:46828734 A/G cg14993813 chr1:46806288 NSUN4 -0.48 -6.14 -0.32 2.33e-9 Menopause (age at onset); CRC cis rs1129187 0.755 rs9471976 chr6:42920549 G/T cg02359409 chr6:42947317 PEX6 -0.69 -11.48 -0.53 7.02e-26 Alzheimer's disease in APOE e4+ carriers; CRC cis rs9912789 0.687 rs9892874 chr17:79188303 G/C cg14413466 chr17:79170920 AZI1 -0.38 -6.57 -0.34 2e-10 Frontotemporal dementia; CRC cis rs798554 0.757 rs1182185 chr7:2872233 A/G cg14895029 chr7:2775587 GNA12 -0.41 -6.15 -0.32 2.29e-9 Height; CRC cis rs7523050 0.730 rs12079547 chr1:109469314 A/C cg08274380 chr1:109419600 GPSM2 0.72 6.4 0.33 5.31e-10 Fat distribution (HIV); CRC cis rs11155671 0.530 rs4869763 chr6:150211684 T/C cg07701084 chr6:150067640 NUP43 0.48 6.93 0.36 2.3e-11 Testicular germ cell tumor; CRC cis rs7208859 0.623 rs11650982 chr17:29129955 A/G cg01831904 chr17:28903510 LRRC37B2 -0.63 -6.49 -0.34 3.2e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs3858526 0.959 rs11039699 chr11:5951091 G/A cg02574844 chr11:5959923 NA -0.46 -6.45 -0.33 4.08e-10 DNA methylation (variation); CRC cis rs2204008 0.701 rs3898237 chr12:38219714 A/G cg26384229 chr12:38710491 ALG10B 0.68 9.03 0.45 1.49e-17 Bladder cancer; CRC cis rs3106136 0.843 rs901615 chr4:95228687 A/C cg11021082 chr4:95130006 SMARCAD1 -0.44 -6.73 -0.35 7.49e-11 Capecitabine sensitivity; CRC cis rs2708977 0.965 rs2314109 chr2:97243532 A/G cg01950434 chr2:97203154 ARID5A -0.48 -7.03 -0.36 1.16e-11 Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes; CRC cis rs853679 0.723 rs9366718 chr6:28205502 A/T cg15786705 chr6:28176104 NA 0.63 6.77 0.35 5.94e-11 Depression; CRC cis rs7932354 0.583 rs10734548 chr11:46787573 T/C cg19486271 chr11:47235900 DDB2 -0.43 -6.5 -0.34 2.99e-10 Bone mineral density (hip);Bone mineral density; CRC cis rs7586879 0.639 rs2384058 chr2:25100328 A/G cg22495460 chr2:25135724 ADCY3 -0.83 -15.86 -0.66 1.83e-42 Body mass index; CRC cis rs3733585 0.673 rs116046986 chr4:9957794 A/G cg00071950 chr4:10020882 SLC2A9 -0.54 -9.65 -0.47 1.5e-19 Cleft plate (environmental tobacco smoke interaction); CRC cis rs4713118 0.615 rs9348772 chr6:27656090 G/T cg06470822 chr6:28175283 NA 0.58 8.35 0.42 1.95e-15 Parkinson's disease; CRC cis rs9322193 0.962 rs3805748 chr6:150093678 C/T cg13206674 chr6:150067644 NUP43 0.55 7.88 0.4 4.99e-14 Lung cancer; CRC cis rs2457480 0.516 rs3900567 chr10:44651421 C/T cg09554077 chr10:44749378 NA 0.46 5.94 0.31 7.3e-9 Coronary artery disease; CRC cis rs1552244 1.000 rs6804473 chr3:10060425 C/T cg10729496 chr3:10149963 C3orf24 0.5 6.67 0.34 1.1e-10 Alzheimer's disease; CRC cis rs9372498 0.536 rs9481821 chr6:118846022 A/C cg01339444 chr6:118972232 C6orf204 0.54 6.15 0.32 2.25e-9 Diastolic blood pressure; CRC cis rs7811142 0.667 rs3873746 chr7:99935097 G/A cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.7 9.78 0.47 5.41e-20 Platelet count; CRC cis rs62432291 0.681 rs365045 chr6:159632250 A/G cg14500486 chr6:159655392 FNDC1 0.81 10.71 0.51 3.53e-23 Joint mobility (Beighton score); CRC trans rs7873102 0.702 rs7028020 chr9:38007747 C/T cg06699617 chr13:45491953 NA -0.4 -5.99 -0.31 5.5e-9 Brain structure; CRC trans rs62103177 0.733 rs62096748 chr18:77619699 T/C cg05926928 chr17:57297772 GDPD1 1.02 10.07 0.49 5.84e-21 Opioid sensitivity; CRC cis rs7618915 0.531 rs77146033 chr3:52701501 G/T cg05573699 chr3:52720067 GNL3;PBRM1 -0.47 -6.65 -0.34 1.19e-10 Bipolar disorder; CRC cis rs4975709 0.589 rs4975707 chr5:1864028 C/T cg20790798 chr5:1857306 NA -0.43 -6.66 -0.34 1.14e-10 Cardiovascular disease risk factors; CRC cis rs889312 0.500 rs3099460 chr5:56133748 G/C cg03609598 chr5:56110824 MAP3K1 -0.43 -5.88 -0.31 1.01e-8 Breast cancer;Breast cancer (early onset); CRC cis rs9811920 0.581 rs793468 chr3:99538346 T/C cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G -0.45 -6.04 -0.32 4.21e-9 Axial length; CRC cis rs1656402 0.953 rs10933398 chr2:233440544 G/A cg03852847 chr2:233439513 NA -0.41 -6.75 -0.35 6.81e-11 Non-small cell lung cancer (survival); CRC cis rs7208859 0.673 rs9895684 chr17:29242600 G/A cg14008862 chr17:28927542 LRRC37B2 0.56 5.8 0.3 1.52e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC trans rs1973993 0.708 rs6593605 chr1:96956775 A/G cg10631902 chr5:14652156 NA -0.41 -6.82 -0.35 4.47e-11 Weight; CRC cis rs13256369 0.950 rs12548792 chr8:8568031 T/C cg18904891 chr8:8559673 CLDN23 0.52 6.96 0.36 1.84e-11 Obesity-related traits; CRC cis rs6076065 0.723 rs7269627 chr20:23362727 A/T cg11657817 chr20:23433608 CST11 0.45 6.79 0.35 5.39e-11 Facial morphology (factor 15, philtrum width); CRC cis rs6570726 0.935 rs391820 chr6:145821284 C/T cg23711669 chr6:146136114 FBXO30 0.69 12.05 0.55 6.08e-28 Lobe attachment (rater-scored or self-reported); CRC cis rs11122272 0.735 rs973254 chr1:231521149 T/A cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.56 -8.56 -0.43 4.41e-16 Hemoglobin concentration; CRC cis rs12586317 0.534 rs1568200 chr14:35419592 C/T cg05294307 chr14:35346193 BAZ1A -0.68 -8.53 -0.43 5.48e-16 Psoriasis; CRC cis rs4766566 0.651 rs4766505 chr12:111758620 A/G cg10833066 chr12:111807467 FAM109A 0.55 7.6 0.39 3.03e-13 Atrial fibrillation;Renal underexcretion gout;Gout;Renal overload gout; CRC cis rs2795502 0.873 rs1891324 chr10:43399581 A/G cg27426351 chr10:43362370 NA 0.61 7.43 0.38 9.34e-13 Blood protein levels; CRC cis rs873946 0.564 rs2803992 chr10:134550882 T/C cg27286337 chr10:134555280 INPP5A 0.72 10.0 0.48 1.02e-20 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CRC cis rs9457247 1.000 rs398278 chr6:167388169 A/G cg23791538 chr6:167370224 RNASET2 -0.36 -5.64 -0.3 3.66e-8 Crohn's disease; CRC cis rs72945132 0.882 rs56368270 chr11:70162590 A/G cg14191688 chr11:70257035 CTTN 0.45 5.97 0.31 6.14e-9 Coronary artery disease; CRC cis rs870825 0.616 rs55685500 chr4:185614810 G/A cg04058563 chr4:185651563 MLF1IP 0.7 7.71 0.39 1.48e-13 Blood protein levels; CRC cis rs35110281 0.667 rs4819285 chr21:45118970 C/T cg04455712 chr21:45112962 RRP1B -0.43 -8.31 -0.42 2.51e-15 Mean corpuscular volume; CRC cis rs7811142 0.830 rs28495773 chr7:99943583 A/T cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.74 9.44 0.46 7.13e-19 Platelet count; CRC cis rs9303280 0.901 rs883770 chr17:38063381 C/T cg20243544 chr17:37824526 PNMT 0.46 7.09 0.36 8.38e-12 Self-reported allergy; CRC cis rs9649465 0.967 rs12534834 chr7:123307079 T/C cg03229431 chr7:123269106 ASB15 -0.37 -5.76 -0.3 1.91e-8 Migraine; CRC cis rs7824557 0.527 rs2572449 chr8:11239137 A/G cg08071915 chr8:12219732 FAM66A -0.32 -5.77 -0.3 1.85e-8 Retinal vascular caliber; CRC cis rs17125944 0.505 rs74620173 chr14:53194068 G/T cg00686598 chr14:53173677 PSMC6 1.18 10.78 0.51 2.11e-23 Alzheimer's disease (late onset); CRC cis rs709400 0.930 rs2274268 chr14:104029378 C/G cg01849466 chr14:104193079 ZFYVE21 0.36 5.71 0.3 2.54e-8 Body mass index; CRC cis rs11969893 0.737 rs4098482 chr6:101377808 C/T cg12253828 chr6:101329408 ASCC3 0.83 6.89 0.35 2.89e-11 Economic and political preferences (immigration/crime); CRC cis rs12024301 0.557 rs10911397 chr1:183646757 A/T cg11505048 chr1:183622726 RGL1;APOBEC4 0.64 5.73 0.3 2.32e-8 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs7769051 0.522 rs6928933 chr6:133116073 G/A cg22852734 chr6:133119734 C6orf192 1.04 7.73 0.39 1.32e-13 Type 2 diabetes nephropathy; CRC cis rs67311347 1.000 rs13073003 chr3:40504326 C/T cg09455208 chr3:40491958 NA -0.45 -9.15 -0.45 6.27e-18 Renal cell carcinoma; CRC cis rs919433 0.963 rs4850428 chr2:198169772 G/A cg20885578 chr2:198174922 NA -0.44 -7.08 -0.36 8.97e-12 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC cis rs1448094 0.617 rs2221319 chr12:86468064 C/A cg02569458 chr12:86230093 RASSF9 -0.42 -7.09 -0.36 8.05e-12 Major depressive disorder; CRC trans rs17685 0.753 rs11764129 chr7:75761890 T/C cg19862616 chr7:65841803 NCRNA00174 0.99 18.11 0.71 2.51e-51 Coffee consumption;Coffee consumption (cups per day); CRC cis rs11148252 0.538 rs3368 chr13:52707240 C/G cg12458913 chr13:53173898 NA 0.46 6.77 0.35 5.99e-11 Lewy body disease; CRC trans rs10982213 0.830 rs2274163 chr9:117188714 C/T cg05796909 chr17:7465070 SENP3 0.39 6.01 0.31 4.81e-9 Interleukin-6 levels; CRC cis rs798766 1.000 rs798756 chr4:1707447 T/C cg05874882 chr4:1763078 NA -0.37 -6.62 -0.34 1.42e-10 Bladder cancer;Urinary bladder cancer; CRC trans rs6951245 1.000 rs77868187 chr7:1093968 A/C cg13565492 chr6:43139072 SRF -0.72 -7.46 -0.38 7.73e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg10827434 chr1:84944976 RPF1 0.45 7.5 0.38 6.05e-13 Liver disease severity in Alagille syndrome; CRC cis rs7647973 0.710 rs7629322 chr3:49621994 C/T cg03060546 chr3:49711283 APEH 0.63 7.44 0.38 8.87e-13 Menarche (age at onset); CRC cis rs595982 0.559 rs117227130 chr19:49367959 A/G cg21252483 chr19:49399788 TULP2 -0.36 -5.93 -0.31 7.76e-9 Red cell distribution width; CRC cis rs2404602 0.692 rs1116535 chr15:77009514 C/G cg23625390 chr15:77176239 SCAPER -0.48 -7.05 -0.36 1.04e-11 Blood metabolite levels; CRC cis rs72781680 0.898 rs72798041 chr2:23953076 T/C cg08917208 chr2:24149416 ATAD2B 1.01 9.49 0.46 4.73e-19 Lymphocyte counts; CRC cis rs6519955 0.765 rs7292527 chr22:46423125 G/T cg05468064 chr22:46423449 NA -0.47 -9.05 -0.45 1.24e-17 Dupuytren's disease; CRC cis rs1448094 0.817 rs73176252 chr12:86347649 T/A cg25456477 chr12:86230367 RASSF9 0.33 5.62 0.3 4.16e-8 Major depressive disorder; CRC cis rs2404602 0.716 rs67204011 chr15:76846555 C/T cg03037974 chr15:76606532 NA 0.66 11.44 0.53 9.38e-26 Blood metabolite levels; CRC cis rs780096 0.526 rs780102 chr2:27659491 T/C cg21248554 chr2:27665150 KRTCAP3 -0.34 -7.95 -0.4 3.07e-14 Total body bone mineral density; CRC cis rs2688608 0.592 rs11000757 chr10:75486815 T/C cg16540259 chr10:75572220 NDST2 0.38 5.91 0.31 8.72e-9 Inflammatory bowel disease; CRC cis rs10878977 0.542 rs11177663 chr12:69818859 C/T cg20891283 chr12:69753455 YEATS4 -0.58 -5.65 -0.3 3.4e-8 Colorectal cancer; CRC cis rs3096299 0.503 rs9940093 chr16:89558705 G/A cg02187348 chr16:89574699 SPG7 0.41 6.0 0.31 5.34e-9 Multiple myeloma (IgH translocation); CRC cis rs9322193 0.962 rs3805752 chr6:150116626 C/T cg05861140 chr6:150128134 PCMT1 -0.4 -6.12 -0.32 2.59e-9 Lung cancer; CRC cis rs6912958 0.525 rs242262 chr6:88018057 A/C cg08069147 chr6:88032118 GJB7;C6orf162 0.72 11.59 0.54 2.77e-26 Monocyte percentage of white cells; CRC cis rs2108622 0.727 rs76984410 chr19:15982700 C/T cg13772218 chr19:15982569 NA 0.49 7.01 0.36 1.39e-11 Circulating phylloquinone levels;Vitamin E levels;Acenocoumarol maintenance dosage;Response to Vitamin E supplementation;Metabolite levels;Warfarin maintenance dose; CRC cis rs6840360 1.000 rs4696104 chr4:152600451 A/G cg09659197 chr4:152720779 NA 0.52 11.13 0.52 1.23e-24 Intelligence (multi-trait analysis); CRC cis rs4290604 0.748 rs10929216 chr2:238080938 C/T cg23555395 chr2:238036564 NA -0.61 -6.18 -0.32 1.86e-9 Asthma; CRC cis rs6598955 0.671 rs11579354 chr1:26604071 T/G cg04990556 chr1:26633338 UBXN11 0.53 5.73 0.3 2.23e-8 Obesity-related traits; CRC cis rs2011503 1.000 rs76790018 chr19:19652157 G/A cg11584989 chr19:19387371 SF4 0.58 6.47 0.34 3.47e-10 Bipolar disorder; CRC trans rs2228479 0.850 rs17227064 chr16:89816314 A/G cg21302420 chr1:112162376 RAP1A 0.72 6.01 0.31 5.05e-9 Skin colour saturation; CRC cis rs7044106 0.762 rs1886337 chr9:123443776 G/C cg09586646 chr9:123605570 PSMD5;LOC253039 0.61 8.92 0.44 3.29e-17 Hip circumference adjusted for BMI; CRC cis rs13118159 0.771 rs13117476 chr4:1334721 A/G cg23123621 chr4:1343375 KIAA1530 0.39 7.03 0.36 1.22e-11 Longevity; CRC cis rs2730245 1.000 rs6965685 chr7:158726462 C/T cg24397884 chr7:158709396 WDR60 0.98 17.33 0.69 2.95e-48 Height; CRC cis rs60871478 0.786 rs12536056 chr7:831351 T/A cg05535760 chr7:792225 HEATR2 -0.99 -12.31 -0.56 6.71e-29 Cerebrospinal P-tau181p levels; CRC cis rs919433 0.963 rs6738836 chr2:198182432 A/G cg20885578 chr2:198174922 NA -0.42 -6.69 -0.35 9.64e-11 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC cis rs11628318 0.617 rs11626481 chr14:103086356 A/G cg08075719 chr14:103021372 NA -0.66 -7.69 -0.39 1.71e-13 Platelet count; CRC cis rs6089584 0.606 rs6089599 chr20:60576992 A/G cg13770153 chr20:60521292 NA 0.42 7.06 0.36 1.02e-11 Body mass index; CRC cis rs412000 0.560 rs4793583 chr17:56451407 A/C cg05425664 chr17:57184151 TRIM37 0.43 6.57 0.34 2.01e-10 Primary tooth development (time to first tooth eruption); CRC cis rs7312933 0.585 rs7969814 chr12:42669657 C/G cg11827402 chr12:42719852 PPHLN1;ZCRB1 0.62 8.72 0.43 1.44e-16 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CRC cis rs992157 0.835 rs4674283 chr2:219144254 G/A cg04880052 chr2:219191631 PNKD -0.44 -6.98 -0.36 1.66e-11 Colorectal cancer; CRC cis rs751728 0.638 rs4607416 chr6:33784998 G/C cg25922239 chr6:33757077 LEMD2 0.44 6.13 0.32 2.53e-9 Crohn's disease; CRC cis rs28374715 0.532 rs28535540 chr15:41659277 G/A cg18705301 chr15:41695430 NDUFAF1 -1.12 -19.64 -0.73 2.23e-57 Ulcerative colitis; CRC cis rs17376456 0.825 rs36042718 chr5:93180997 C/T cg25358565 chr5:93447407 FAM172A 1.06 10.36 0.5 5.88e-22 Diabetic retinopathy; CRC cis rs758324 0.947 rs1948704 chr5:131171653 A/G cg25547332 chr5:131281432 NA 0.38 5.64 0.3 3.67e-8 Alzheimer's disease in APOE e4- carriers; CRC trans rs7726839 0.540 rs72705030 chr5:645562 C/T cg11887960 chr12:57824829 NA 0.64 7.08 0.36 8.89e-12 Obesity-related traits; CRC cis rs10504229 0.593 rs116916898 chr8:57984958 G/A cg24829409 chr8:58192753 C8orf71 -0.66 -7.16 -0.37 5.37e-12 Developmental language disorder (linguistic errors); CRC cis rs904251 0.797 rs1776460 chr6:37485484 A/G cg01843034 chr6:37503916 NA -0.46 -8.71 -0.43 1.54e-16 Cognitive performance; CRC cis rs875971 0.564 rs313804 chr7:65514622 A/G cg00343986 chr7:65444356 GUSB 0.46 6.75 0.35 6.76e-11 Aortic root size; CRC cis rs727563 0.552 rs4822045 chr22:41985958 C/A cg06634786 chr22:41940651 POLR3H -0.62 -6.38 -0.33 6.07e-10 Crohn's disease;Inflammatory bowel disease; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg12796498 chr2:1276796 SNTG2 -0.37 -6.34 -0.33 7.64e-10 Liver disease severity in Alagille syndrome; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg16642045 chr4:155471719 PLRG1 0.43 6.49 0.34 3.16e-10 Liver disease severity in Alagille syndrome; CRC cis rs9875589 0.509 rs2607757 chr3:14081948 A/G cg14375111 chr3:14165186 TMEM43;CHCHD4 -0.41 -6.12 -0.32 2.61e-9 Ovarian reserve; CRC cis rs10782582 0.593 rs6673786 chr1:76149637 C/T cg03433033 chr1:76189801 ACADM -0.43 -6.16 -0.32 2.1e-9 Daytime sleep phenotypes; CRC cis rs8072100 1.000 rs4794048 chr17:45763073 A/C cg25173405 chr17:45401733 C17orf57 -0.49 -7.77 -0.39 9.88e-14 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs6460942 1.000 rs6460942 chr7:12420989 T/C cg10578991 chr7:12443926 VWDE -0.49 -5.62 -0.3 4.01e-8 Coronary artery disease; CRC cis rs6088590 0.965 rs6120727 chr20:33374102 T/C cg24642439 chr20:33292090 TP53INP2 0.6 10.56 0.5 1.26e-22 Coronary artery disease; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg10591475 chr6:28109693 ZNF192 0.5 7.08 0.36 9.03e-12 Response to antipsychotic treatment; CRC cis rs910316 0.967 rs12890371 chr14:75593839 T/C cg03030879 chr14:75389066 RPS6KL1 -0.47 -7.4 -0.38 1.11e-12 Height; CRC cis rs4862750 0.914 rs1863405 chr4:187874528 G/T cg06074448 chr4:187884817 NA 0.58 10.96 0.52 4.77e-24 Lobe attachment (rater-scored or self-reported); CRC cis rs853679 0.628 rs9368560 chr6:28159960 T/C cg21251018 chr6:28226885 NKAPL 0.46 6.39 0.33 5.52e-10 Depression; CRC cis rs875971 1.000 rs4718307 chr7:65610988 A/G cg18876405 chr7:65276391 NA -0.52 -8.98 -0.44 2.07e-17 Aortic root size; CRC cis rs7647973 1.000 rs62261249 chr3:49594060 T/C cg07690219 chr3:49449608 TCTA;RHOA 0.56 6.13 0.32 2.48e-9 Menarche (age at onset); CRC cis rs7208859 0.673 rs11658435 chr17:29228561 A/G cg01831904 chr17:28903510 LRRC37B2 -0.56 -5.83 -0.31 1.35e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs853679 0.517 rs34716816 chr6:28046169 C/A cg12963246 chr6:28129442 ZNF389 0.47 5.61 0.3 4.26e-8 Depression; CRC cis rs4073416 0.542 rs1959145 chr14:65954740 A/G cg03016385 chr14:66212404 NA -0.41 -5.69 -0.3 2.76e-8 N-glycan levels; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg20774646 chr1:149858164 HIST2H2BE;HIST2H2AC 0.4 6.1 0.32 2.99e-9 Liver disease severity in Alagille syndrome; CRC cis rs10927875 0.541 rs1048237 chr1:16341733 T/C cg22431228 chr1:16359049 CLCNKA -0.37 -6.72 -0.35 8.23e-11 Dilated cardiomyopathy; CRC cis rs7568458 0.527 rs35416445 chr2:85773659 A/G cg02493740 chr2:85810744 VAMP5 -0.55 -8.3 -0.42 2.75e-15 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); CRC cis rs735539 0.645 rs9552251 chr13:21180247 A/G cg27499820 chr13:21296301 IL17D -0.42 -5.98 -0.31 5.8e-9 Dental caries; CRC cis rs9322193 0.962 rs9688412 chr6:150124283 A/G cg05861140 chr6:150128134 PCMT1 0.44 7.24 0.37 3.22e-12 Lung cancer; CRC cis rs7258465 0.931 rs11673604 chr19:18540988 T/C cg10790698 chr19:18539756 SSBP4 -0.47 -8.78 -0.44 8.9e-17 Breast cancer; CRC cis rs7932354 0.583 rs2306027 chr11:46907827 C/T cg19486271 chr11:47235900 DDB2 -0.43 -6.42 -0.33 4.75e-10 Bone mineral density (hip);Bone mineral density; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg24960158 chr3:97690786 MINA 0.45 5.96 0.31 6.47e-9 Thyroid stimulating hormone; CRC cis rs9894429 0.646 rs7406828 chr17:79619226 A/G cg18240062 chr17:79603768 NPLOC4 -0.46 -7.18 -0.37 4.69e-12 Eye color traits; CRC cis rs1799949 0.965 rs8176087 chr17:41270666 C/A cg19454999 chr17:41278357 BRCA1;NBR2 0.53 8.21 0.41 4.99e-15 Menopause (age at onset); CRC cis rs2841277 0.616 rs1048257 chr14:105404384 T/C cg14403583 chr14:105418241 AHNAK2 -0.34 -6.1 -0.32 3.05e-9 Rheumatoid arthritis; CRC cis rs7737355 0.947 rs6596029 chr5:130899079 T/C cg06307176 chr5:131281290 NA 0.42 5.96 0.31 6.48e-9 Life satisfaction; CRC cis rs4713118 0.662 rs9380046 chr6:28030499 T/C cg06470822 chr6:28175283 NA 0.95 13.59 0.6 1.08e-33 Parkinson's disease; CRC cis rs853679 0.517 rs4713143 chr6:28106759 A/C cg12273811 chr6:28175739 NA 0.73 9.36 0.46 1.34e-18 Depression; CRC cis rs9522267 0.737 rs12429582 chr13:112226657 A/G cg10483660 chr13:112241077 NA -0.41 -7.29 -0.37 2.3e-12 Hepatitis; CRC cis rs1448094 0.511 rs4469976 chr12:86146723 T/C cg02569458 chr12:86230093 RASSF9 -0.48 -8.08 -0.41 1.27e-14 Major depressive disorder; CRC cis rs6540556 0.769 rs9430017 chr1:209925058 C/T cg05527609 chr1:210001259 C1orf107 -0.57 -6.39 -0.33 5.73e-10 Red blood cell count; CRC cis rs11971779 0.680 rs10242419 chr7:139089380 A/G cg23387468 chr7:139079360 LUC7L2 -0.4 -6.98 -0.36 1.64e-11 Diisocyanate-induced asthma; CRC cis rs244731 1.000 rs244731 chr5:176539679 C/T cg05207973 chr5:176823642 SLC34A1 0.41 5.89 0.31 9.77e-9 Urate levels in lean individuals; CRC cis rs7811142 0.830 rs11771936 chr7:99943283 A/G cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.73 9.7 0.47 1.01e-19 Platelet count; CRC cis rs3617 0.625 rs7652667 chr3:52866535 C/A cg11645453 chr3:52864694 ITIH4 -0.46 -9.17 -0.45 5.24e-18 Red blood cell count;Autism spectrum disorder or schizophrenia; CRC trans rs7873102 0.702 rs7028020 chr9:38007747 C/T cg19764421 chr1:228783274 DUSP5P -0.4 -6.25 -0.33 1.31e-9 Brain structure; CRC cis rs4728302 0.869 rs889825 chr7:133596227 A/G cg10665199 chr7:133106180 EXOC4 0.38 5.79 0.3 1.66e-8 Intelligence;Intelligence (multi-trait analysis); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg00251705 chr11:57434686 ZDHHC5 0.44 6.14 0.32 2.34e-9 Response to antipsychotic treatment; CRC cis rs950027 0.620 rs1145076 chr15:45684508 G/T cg21132104 chr15:45694354 SPATA5L1 0.42 6.19 0.32 1.83e-9 Response to fenofibrate (adiponectin levels); CRC cis rs9611565 0.659 rs4822034 chr22:41931010 T/C cg06481639 chr22:41940642 POLR3H -0.52 -5.97 -0.31 6.25e-9 Vitiligo; CRC cis rs2204008 0.775 rs2387809 chr12:38363338 T/A cg26384229 chr12:38710491 ALG10B 0.69 9.8 0.48 4.77e-20 Bladder cancer; CRC trans rs3733585 0.577 rs5014939 chr4:9953253 T/A cg26043149 chr18:55253948 FECH -0.5 -7.71 -0.39 1.51e-13 Cleft plate (environmental tobacco smoke interaction); CRC cis rs73001065 0.688 rs59148799 chr19:19484008 A/G cg03709012 chr19:19516395 GATAD2A 0.81 6.83 0.35 4.18e-11 LDL cholesterol; CRC cis rs1267303 0.682 rs1886117 chr1:46964909 T/A cg25110126 chr1:46999211 NA -0.35 -5.83 -0.31 1.31e-8 Monobrow; CRC cis rs6502050 0.731 rs12150589 chr17:80158233 A/T cg19223190 chr17:80058835 NA 0.4 6.52 0.34 2.63e-10 Life satisfaction; CRC trans rs693839 0.691 rs4884161 chr13:81089506 C/T cg07052627 chr11:46401447 MDK;DGKZ -0.38 -6.13 -0.32 2.46e-9 Body fat percentage; CRC cis rs2991971 0.933 rs2356553 chr1:46009313 G/C cg15605315 chr1:45957053 TESK2 0.44 7.02 0.36 1.27e-11 High light scatter reticulocyte count; CRC cis rs427394 0.582 rs274662 chr5:6704860 G/A cg15145174 chr5:6755386 POLS -0.46 -6.4 -0.33 5.32e-10 Menopause (age at onset); CRC cis rs9381040 1.000 rs2093395 chr6:41155026 C/G cg03526776 chr6:41159608 TREML2 -0.43 -7.43 -0.38 9.66e-13 Alzheimer's disease (late onset); CRC cis rs10504229 0.683 rs11774847 chr8:58140775 T/A cg05313129 chr8:58192883 C8orf71 -0.5 -5.89 -0.31 9.49e-9 Developmental language disorder (linguistic errors); CRC cis rs12142240 0.698 rs66972124 chr1:46807445 A/G cg14993813 chr1:46806288 NSUN4 -0.49 -6.22 -0.32 1.5e-9 Menopause (age at onset); CRC cis rs2302190 0.882 rs8067183 chr17:56462023 G/A cg12560992 chr17:57184187 TRIM37 0.47 5.75 0.3 2.08e-8 Vitamin D levels; CRC cis rs2806561 0.704 rs674386 chr1:23521835 G/A cg12483005 chr1:23474871 LUZP1 0.51 7.29 0.37 2.34e-12 Height; CRC cis rs55665837 1.000 rs10047429 chr11:14439032 C/T cg19336497 chr11:14380999 RRAS2 -0.39 -6.73 -0.35 7.56e-11 Vitamin D levels; CRC cis rs10035650 0.510 rs6898585 chr5:93896128 A/G cg21051031 chr5:93905482 C5orf36;MIR1974 0.41 6.71 0.35 8.28e-11 Cancer; CRC cis rs6582630 0.502 rs10880450 chr12:38440294 G/C cg13010199 chr12:38710504 ALG10B 0.46 6.15 0.32 2.27e-9 Drug-induced liver injury (flucloxacillin); CRC cis rs875971 0.862 rs1643375 chr7:65872677 T/C cg18252515 chr7:66147081 NA -0.41 -5.94 -0.31 7.15e-9 Aortic root size; CRC cis rs13191362 1.000 rs35092540 chr6:163090778 A/G cg14584255 chr6:163149320 PACRG;PARK2 0.44 6.29 0.33 1.02e-9 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs4509693 1.000 rs4244340 chr10:102499268 G/C cg23167259 chr10:102495509 NA -0.49 -6.83 -0.35 4.22e-11 Alzheimer's disease; CRC cis rs1448094 0.512 rs6539926 chr12:86244460 G/A cg19622623 chr12:86230825 RASSF9 -0.41 -6.7 -0.35 9.04e-11 Major depressive disorder; CRC trans rs3858526 0.917 rs9284148 chr11:5973185 G/C cg01505111 chr6:125621795 HDDC2 0.4 6.02 0.31 4.57e-9 DNA methylation (variation); CRC cis rs6785206 0.614 rs2712430 chr3:128337438 A/C cg16766828 chr3:128327626 NA -0.51 -5.76 -0.3 1.93e-8 Lymphocyte percentage of white cells; CRC trans rs7618501 1.000 rs7431106 chr3:49808374 G/A cg21665057 chr3:196295764 WDR53;FBXO45 0.86 16.08 0.66 2.35e-43 Intelligence (multi-trait analysis); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg18284523 chr14:24711562 TINF2 0.45 6.96 0.36 1.84e-11 Liver disease severity in Alagille syndrome; CRC cis rs2721195 0.967 rs10108150 chr8:145687475 A/G cg15857475 chr8:145742913 RECQL4;LRRC14 -0.66 -10.49 -0.5 2.19e-22 Age at first birth; CRC cis rs1218582 0.772 rs4845689 chr1:154885524 A/G cg09359103 chr1:154839909 KCNN3 -0.71 -12.5 -0.57 1.32e-29 Prostate cancer; CRC cis rs6964587 0.967 rs34863529 chr7:91644341 C/G cg17063962 chr7:91808500 NA 0.79 12.78 0.58 1.18e-30 Breast cancer; CRC cis rs889398 0.617 rs3790083 chr16:69895286 C/T cg00738113 chr16:70207722 CLEC18C 0.35 6.18 0.32 1.89e-9 Body mass index; CRC cis rs9660992 1.000 rs3851296 chr1:205253839 A/C cg21643547 chr1:205240462 TMCC2 -0.42 -7.08 -0.36 8.74e-12 Mean corpuscular volume;Mean platelet volume; CRC cis rs1552244 0.572 rs113406084 chr3:10170190 T/C cg10729496 chr3:10149963 C3orf24 0.48 5.63 0.3 3.81e-8 Alzheimer's disease; CRC trans rs7613875 0.663 rs6762477 chr3:50093209 G/A cg21665057 chr3:196295764 WDR53;FBXO45 -0.44 -6.37 -0.33 6.5e-10 Body mass index; CRC cis rs6964587 1.000 rs10270598 chr7:91700827 T/C cg17063962 chr7:91808500 NA 0.8 14.04 0.61 1.97e-35 Breast cancer; CRC cis rs9916302 0.904 rs8077104 chr17:37530510 A/G cg03013999 chr17:37608204 MED1 -0.47 -7.4 -0.38 1.14e-12 Glomerular filtration rate (creatinine); CRC cis rs62229266 0.609 rs2835253 chr21:37419745 T/C cg12218747 chr21:37451666 NA -0.37 -6.24 -0.33 1.31e-9 Mitral valve prolapse; CRC cis rs4662945 0.688 rs34713181 chr2:130212385 G/A cg05962382 chr2:130345044 NA -0.33 -5.61 -0.3 4.23e-8 Response to cytidine analogues (gemcitabine); CRC cis rs798554 0.655 rs798492 chr7:2799184 C/T cg19717773 chr7:2847554 GNA12 0.44 7.26 0.37 2.81e-12 Height; CRC cis rs6700896 0.931 rs4655764 chr1:66126159 C/T cg04111102 chr1:66153794 NA 0.34 6.06 0.32 3.74e-9 C-reactive protein;Mean corpuscular volume;Mean corpuscular hemoglobin; CRC cis rs8072100 0.840 rs9895746 chr17:45479099 C/A cg08085267 chr17:45401833 C17orf57 -0.68 -11.19 -0.53 7.65e-25 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs3018066 0.666 rs6829795 chr4:107065220 T/C cg01869342 chr4:106983673 TBCK 0.48 6.15 0.32 2.25e-9 Cancer; CRC cis rs58688157 0.705 rs12419720 chr11:598205 C/G cg01842473 chr11:617407 IRF7;MUPCDH -0.55 -6.58 -0.34 1.88e-10 Systemic lupus erythematosus; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg14775296 chr2:66672841 MEIS1 0.26 6.82 0.35 4.34e-11 Liver disease severity in Alagille syndrome; CRC cis rs2976388 0.556 rs4736321 chr8:143822194 C/T cg12516270 chr8:143859308 LYNX1 -0.39 -6.15 -0.32 2.24e-9 Urinary tract infection frequency; CRC cis rs78545713 0.649 rs41266811 chr6:26216656 T/C cg01420254 chr6:26195488 NA 0.67 6.0 0.31 5.2e-9 Iron status biomarkers (total iron binding capacity); CRC cis rs4555082 0.834 rs2816631 chr14:105739477 G/A cg06808227 chr14:105710500 BRF1 -0.6 -8.53 -0.43 5.48e-16 Mean platelet volume;Platelet distribution width; CRC cis rs4665809 0.590 rs6716858 chr2:26423414 G/A cg27170947 chr2:26402098 FAM59B -0.57 -8.03 -0.4 1.74e-14 Gut microbiome composition (summer); CRC cis rs7618915 0.501 rs9917834 chr3:52634619 A/C cg05573699 chr3:52720067 GNL3;PBRM1 -0.47 -6.96 -0.36 1.87e-11 Bipolar disorder; CRC cis rs2777491 0.957 rs919961 chr15:41651721 A/G cg18705301 chr15:41695430 NDUFAF1 -0.68 -11.18 -0.52 8.1e-25 Ulcerative colitis; CRC cis rs6547741 1.000 rs11127071 chr2:27838058 C/A cg27432699 chr2:27873401 GPN1 0.77 13.65 0.6 6.57e-34 Oral cavity cancer; CRC cis rs1046896 1.000 rs1046875 chr17:80685426 A/G cg02711726 chr17:80685570 FN3KRP 0.58 9.28 0.46 2.38e-18 Glycated hemoglobin levels; CRC cis rs13108904 0.870 rs11721789 chr4:1254414 C/A cg20887711 chr4:1340912 KIAA1530 0.41 5.86 0.31 1.1e-8 Obesity-related traits; CRC trans rs1814175 0.727 rs2140597 chr11:49873946 G/A cg15704280 chr7:45808275 SEPT13 -0.96 -18.48 -0.71 8.12e-53 Height; CRC cis rs7223966 1.000 rs8076717 chr17:61850301 C/T cg23090583 chr17:61904693 PSMC5;FTSJ3 -0.54 -6.56 -0.34 2.15e-10 Hip circumference adjusted for BMI;Body mass index; CRC cis rs4076764 0.958 rs6691127 chr1:163384831 T/C cg24596788 chr1:163392923 NA -0.67 -10.81 -0.51 1.71e-23 Motion sickness; CRC cis rs78456975 0.943 rs10470006 chr2:1580971 A/C cg12573674 chr2:1569213 NA -0.67 -7.62 -0.39 2.77e-13 Placebo response in major depressive disorder (% change in symptom score); CRC cis rs10504229 1.000 rs57186557 chr8:58177277 A/G cg01721255 chr8:58191610 C8orf71 0.49 6.17 0.32 2e-9 Developmental language disorder (linguistic errors); CRC cis rs972578 0.875 rs5751412 chr22:43408257 A/G cg01576275 chr22:43409880 NA -0.47 -7.51 -0.38 5.7e-13 Mean platelet volume; CRC cis rs75920871 0.588 rs1815789 chr11:116834953 T/C cg20608306 chr11:116969690 SIK3 -0.31 -5.72 -0.3 2.4e-8 Subjective well-being; CRC cis rs3793683 0.556 rs2803989 chr10:134560596 C/T cg06453172 chr10:134556979 INPP5A -0.58 -7.94 -0.4 3.18e-14 Migraine; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg25740925 chr13:95254690 GPR180 0.43 6.23 0.32 1.45e-9 Response to antipsychotic treatment; CRC trans rs11098499 0.779 rs7699346 chr4:120310542 C/T cg25214090 chr10:38739885 LOC399744 0.62 9.73 0.47 7.59e-20 Corneal astigmatism; CRC trans rs11148252 0.574 rs2038826 chr13:53280013 G/A cg18335740 chr13:41363409 SLC25A15 0.75 13.37 0.59 7.39e-33 Lewy body disease; CRC cis rs10504229 0.679 rs11783965 chr8:58130510 T/G cg24829409 chr8:58192753 C8orf71 -0.54 -8.02 -0.4 1.88e-14 Developmental language disorder (linguistic errors); CRC cis rs9649213 0.593 rs7812180 chr7:97969140 A/G cg24562669 chr7:97807699 LMTK2 -0.48 -7.71 -0.39 1.56e-13 Prostate cancer (SNP x SNP interaction); CRC cis rs10450586 0.863 rs7125719 chr11:27288359 G/C cg10370305 chr11:27303972 NA 0.36 5.65 0.3 3.55e-8 Total body bone mineral density; CRC cis rs1552244 0.832 rs61056817 chr3:10027641 C/T cg13047869 chr3:10149882 C3orf24 0.48 6.09 0.32 3.17e-9 Alzheimer's disease; CRC cis rs1059312 0.808 rs2170989 chr12:129291317 T/C cg21616243 chr12:129299702 MGC16384;SLC15A4 0.74 12.91 0.58 4.04e-31 Systemic lupus erythematosus; CRC cis rs1691799 0.899 rs1183272 chr12:66735421 T/C cg16791601 chr12:66731901 HELB -0.73 -12.87 -0.58 5.73e-31 White blood cell count (basophil); CRC cis rs35264875 0.796 rs72928657 chr11:68852336 T/C cg03469862 chr11:68924853 NA 0.46 5.89 0.31 9.37e-9 Blond vs. brown hair color; CRC trans rs6601327 0.641 rs6601350 chr8:9573956 C/G cg06636001 chr8:8085503 FLJ10661 -0.52 -7.46 -0.38 7.56e-13 Multiple myeloma (hyperdiploidy); CRC cis rs11155671 0.530 rs4869763 chr6:150211684 T/C cg13206674 chr6:150067644 NUP43 0.47 6.7 0.35 8.81e-11 Testicular germ cell tumor; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg03361557 chr19:19774500 ATP13A1 0.4 6.52 0.34 2.7e-10 Liver disease severity in Alagille syndrome; CRC trans rs1265507 0.599 rs2076967 chr12:114869758 G/C cg11700868 chr17:38521232 GJD3 0.42 5.99 0.31 5.5e-9 Percent mammographic density; CRC cis rs17127169 0.536 rs74860172 chr1:65497547 T/A cg13853591 chr1:65468921 NA 0.81 5.67 0.3 3.06e-8 Sitting height ratio; CRC cis rs951366 0.789 rs823097 chr1:205681370 G/A cg14159672 chr1:205819179 PM20D1 0.72 10.15 0.49 3.18e-21 Menarche (age at onset); CRC cis rs12701220 0.655 rs7799656 chr7:1140515 C/T cg00990874 chr7:1149470 C7orf50 -0.69 -9.5 -0.46 4.58e-19 Bronchopulmonary dysplasia; CRC cis rs561341 0.739 rs9906455 chr17:30215669 G/A cg13647721 chr17:30228624 UTP6 -0.63 -7.54 -0.38 4.51e-13 Hip circumference adjusted for BMI; CRC cis rs7647973 0.925 rs6769821 chr3:49244657 G/A cg07690219 chr3:49449608 TCTA;RHOA -0.55 -5.94 -0.31 7.41e-9 Menarche (age at onset); CRC cis rs995000 0.783 rs993013 chr1:63111069 G/T cg19896129 chr1:63156450 NA -0.41 -6.31 -0.33 8.92e-10 Triglyceride levels; CRC cis rs17401966 1.000 rs1339458 chr1:10328338 C/T cg19773385 chr1:10388646 KIF1B -0.59 -8.26 -0.41 3.69e-15 Hepatocellular carcinoma; CRC cis rs501916 0.833 rs10519143 chr15:48055567 T/G cg16110827 chr15:48056943 SEMA6D -0.55 -8.41 -0.42 1.26e-15 Inflammatory bowel disease;Ulcerative colitis; CRC cis rs2228479 0.850 rs62054638 chr16:89821131 G/C cg19635926 chr16:89946313 TCF25 0.63 5.68 0.3 3.01e-8 Skin colour saturation; CRC cis rs6960043 0.905 rs2215381 chr7:15054935 G/T cg19272540 chr7:15055459 NA 0.23 6.35 0.33 7.25e-10 Type 2 diabetes; CRC cis rs875971 1.000 rs697970 chr7:65560052 G/C cg12463550 chr7:65579703 CRCP -0.5 -7.24 -0.37 3.21e-12 Aortic root size; CRC cis rs9527 0.614 rs2153774 chr10:104881035 T/C cg15744005 chr10:104629667 AS3MT -0.31 -6.1 -0.32 3.05e-9 Arsenic metabolism; CRC cis rs3617 0.625 rs2239548 chr3:52854186 A/C cg07507251 chr3:52567010 NT5DC2 0.4 6.13 0.32 2.58e-9 Red blood cell count;Autism spectrum disorder or schizophrenia; CRC cis rs7727544 0.735 rs274566 chr5:131715011 A/G cg07395648 chr5:131743802 NA 0.41 6.5 0.34 3e-10 Blood metabolite levels; CRC cis rs270601 0.770 rs61352298 chr5:131600589 G/C cg18758796 chr5:131593413 PDLIM4 0.48 8.79 0.44 8.41e-17 Acylcarnitine levels; CRC cis rs12580194 0.556 rs61957898 chr12:55730423 T/C cg19537932 chr12:55886519 OR6C68 -0.65 -8.32 -0.42 2.4e-15 Cancer; CRC cis rs79349575 0.594 rs1985785 chr17:46967788 T/C cg22482690 chr17:47019901 SNF8 0.48 8.18 0.41 6.13e-15 Type 2 diabetes; CRC cis rs9660992 0.674 rs72745219 chr1:205262271 G/A cg21643547 chr1:205240462 TMCC2 -0.44 -7.06 -0.36 1.01e-11 Mean corpuscular volume;Mean platelet volume; CRC cis rs394563 0.591 rs237029 chr6:149717425 A/G cg07828024 chr6:149772892 ZC3H12D -0.48 -9.03 -0.45 1.43e-17 Dupuytren's disease; CRC cis rs9372498 0.536 rs9489457 chr6:118920285 C/T cg01339444 chr6:118972232 C6orf204 0.55 6.16 0.32 2.08e-9 Diastolic blood pressure; CRC trans rs916888 0.610 rs199452 chr17:44801340 C/T cg22968622 chr17:43663579 NA 0.84 11.63 0.54 2.01e-26 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs796364 0.774 rs112564437 chr2:201074048 G/C cg23649088 chr2:200775458 C2orf69 -0.52 -6.25 -0.33 1.31e-9 Schizophrenia; CRC cis rs4665809 1.000 rs13030858 chr2:26315451 G/A cg25036284 chr2:26402008 FAM59B -0.46 -6.03 -0.32 4.3e-9 Gut microbiome composition (summer); CRC cis rs138880 0.542 rs9616371 chr22:50306338 G/A cg08270630 chr22:50330655 NA -0.52 -5.64 -0.3 3.63e-8 Schizophrenia; CRC cis rs3736594 0.513 rs3811644 chr2:27802805 A/G cg27432699 chr2:27873401 GPN1 0.65 7.88 0.4 4.95e-14 Fasting blood glucose;Fasting blood glucose (BMI interaction); CRC cis rs7493 0.853 rs35686517 chr7:95052611 G/A cg21856205 chr7:94953877 PON1 -0.52 -6.57 -0.34 2.01e-10 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs9463078 0.617 rs9395063 chr6:45040793 T/G cg25276700 chr6:44698697 NA -0.24 -5.76 -0.3 1.88e-8 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; CRC cis rs3858526 0.834 rs10839160 chr11:6002113 T/C cg05234568 chr11:5960015 NA -0.47 -5.99 -0.31 5.53e-9 DNA methylation (variation); CRC cis rs34172651 0.517 rs200528 chr16:24759131 A/G cg06028605 chr16:24865363 SLC5A11 -0.6 -10.05 -0.48 6.56e-21 Intelligence (multi-trait analysis); CRC cis rs76878669 0.561 rs6591215 chr11:66170611 A/C cg18002602 chr11:66138449 SLC29A2 -0.28 -6.02 -0.31 4.78e-9 Educational attainment (years of education); CRC cis rs8180040 0.739 rs11719306 chr3:47184182 G/A cg27129171 chr3:47204927 SETD2 0.76 13.05 0.58 1.2e-31 Colorectal cancer; CRC cis rs4888262 0.526 rs7193508 chr16:74628630 G/T cg01733217 chr16:74700730 RFWD3 0.79 12.02 0.55 7.77e-28 Testicular germ cell tumor; CRC trans rs9858542 0.953 rs7623659 chr3:49414791 C/T cg21665057 chr3:196295764 WDR53;FBXO45 -0.64 -8.75 -0.43 1.1e-16 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs877282 0.898 rs11253349 chr10:765897 C/G cg06581033 chr10:766294 NA -0.53 -5.79 -0.3 1.61e-8 Uric acid levels; CRC cis rs12477438 0.798 rs6712338 chr2:99585457 A/G cg14399236 chr2:99771627 LIPT1;TSGA10 -0.74 -10.37 -0.5 5.51e-22 Chronic sinus infection; CRC cis rs7197653 0.667 rs16957831 chr16:68378341 C/T cg09835421 chr16:68378352 PRMT7 -0.76 -8.1 -0.41 1.12e-14 Magnesium levels; CRC cis rs6460942 0.841 rs17444203 chr7:12461864 C/G cg06484146 chr7:12443880 VWDE 0.67 8.43 0.42 1.1e-15 Coronary artery disease; CRC cis rs4604732 0.631 rs10925043 chr1:247627001 G/A cg02104434 chr1:247694406 LOC148824;OR2C3 0.6 8.82 0.44 6.67e-17 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CRC trans rs2727020 0.754 rs1851990 chr11:49413336 C/T cg11707556 chr5:10655725 ANKRD33B -0.37 -5.97 -0.31 6.15e-9 Coronary artery disease; CRC trans rs60843830 1.000 rs17713729 chr2:249092 A/C cg11347411 chr7:150020925 ACTR3C;LRRC61 0.57 8.97 0.44 2.37e-17 Spherical equivalent (joint analysis main effects and education interaction); CRC cis rs2718058 0.519 rs2598072 chr7:37875319 A/C cg24998770 chr7:37888106 TXNDC3 0.45 7.04 0.36 1.09e-11 Alzheimer's disease (late onset); CRC cis rs270601 0.690 rs162904 chr5:131595784 C/T cg12564285 chr5:131593104 PDLIM4 -0.52 -9.01 -0.44 1.76e-17 Acylcarnitine levels; CRC cis rs4481887 1.000 rs4916125 chr1:248466583 A/T cg13385794 chr1:248469461 NA 0.39 6.98 0.36 1.62e-11 Common traits (Other); CRC cis rs763121 0.853 rs3788544 chr22:39064966 C/T cg06544989 chr22:39130855 UNC84B 0.45 6.66 0.34 1.14e-10 Menopause (age at onset); CRC cis rs4969178 0.965 rs4969186 chr17:76398404 C/G cg20026190 chr17:76395443 PGS1 0.38 5.92 0.31 8.2e-9 HDL cholesterol levels; CRC trans rs1728785 1.000 rs1645923 chr16:68581051 G/A cg04657470 chr2:198365150 HSPE1;HSPD1 0.58 7.07 0.36 9.08e-12 Ulcerative colitis; CRC cis rs2842992 0.789 rs10945635 chr6:160214487 C/A cg16489826 chr6:160211363 TCP1;MRPL18 0.5 6.22 0.32 1.47e-9 Age-related macular degeneration (geographic atrophy); CRC cis rs2380220 0.678 rs4308568 chr6:96009525 A/C cg15832292 chr6:96025679 MANEA -0.56 -6.21 -0.32 1.61e-9 Behavioural disinhibition (generation interaction); CRC cis rs912057 1.000 rs912057 chr6:6736931 C/T cg06612196 chr6:6737390 NA -0.55 -9.14 -0.45 6.83e-18 Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction); CRC cis rs1862618 0.853 rs832584 chr5:56179212 A/G cg24531977 chr5:56204891 C5orf35 0.75 10.53 0.5 1.59e-22 Initial pursuit acceleration; CRC cis rs4820539 1.000 rs5759596 chr22:23475750 G/A cg14186256 chr22:23484241 RTDR1 0.93 18.76 0.72 6.63e-54 Bone mineral density; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg10319399 chr8:145018285 PLEC1 -0.38 -6.04 -0.32 4.11e-9 Myopia (pathological); CRC trans rs7615952 0.576 rs1127717 chr3:125826059 T/C cg07211511 chr3:129823064 LOC729375 -0.69 -9.27 -0.46 2.54e-18 Blood pressure (smoking interaction); CRC cis rs2739330 0.828 rs2186366 chr22:24254113 A/G cg10819733 chr22:24237672 NA 0.35 6.05 0.32 4.03e-9 Liver enzyme levels (gamma-glutamyl transferase); CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg02232396 chr7:77428768 PHTF2;TMEM60 0.43 6.16 0.32 2.11e-9 Anxiety disorder; CRC cis rs897984 0.609 rs35468353 chr16:31056433 A/G cg02466173 chr16:30829666 NA -0.6 -9.02 -0.45 1.59e-17 Dementia with Lewy bodies; CRC cis rs9768139 0.708 rs896780 chr7:158113972 C/T cg25566285 chr7:158114605 PTPRN2 0.52 8.53 0.43 5.56e-16 Calcium levels; CRC cis rs7224685 0.501 rs7222628 chr17:3890429 A/G cg09597638 chr17:3907349 NA 0.7 12.84 0.58 7.5e-31 Type 2 diabetes; CRC cis rs35146811 0.844 rs2070215 chr7:99696797 T/C cg13334819 chr7:99746414 C7orf59 -0.56 -7.02 -0.36 1.3e-11 Coronary artery disease; CRC cis rs56235845 0.964 rs4075958 chr5:176784512 A/G cg06060754 chr5:176797920 RGS14 -0.73 -10.65 -0.51 5.87e-23 Hemoglobin concentration;Hematocrit; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg16267579 chr12:76953818 OSBPL8 0.44 6.05 0.32 3.89e-9 Response to antipsychotic treatment; CRC trans rs1005277 0.505 rs7069702 chr10:38247359 G/T cg27523141 chr10:43048294 ZNF37B -0.45 -6.5 -0.34 2.9e-10 Extrinsic epigenetic age acceleration; CRC cis rs7493 0.755 rs740264 chr7:95021803 T/G cg19678392 chr7:94953810 PON1 -0.53 -6.52 -0.34 2.58e-10 Yu-Zhi constitution type in type 2 diabetes; CRC trans rs4332037 0.805 rs10278591 chr7:1921362 A/G cg11693508 chr17:37793320 STARD3 -0.49 -6.33 -0.33 8.19e-10 Bipolar disorder; CRC cis rs727563 0.635 rs713988 chr22:42159072 A/G cg17554472 chr22:41940697 POLR3H 0.55 5.61 0.3 4.29e-8 Crohn's disease;Inflammatory bowel disease; CRC cis rs10504229 0.683 rs7827014 chr8:58132230 G/A cg24829409 chr8:58192753 C8orf71 -0.55 -8.03 -0.4 1.71e-14 Developmental language disorder (linguistic errors); CRC cis rs2455601 1.000 rs12223690 chr11:8901824 G/A cg09997546 chr11:8931473 C11orf17;ST5 -0.51 -6.05 -0.32 3.85e-9 Schizophrenia; CRC cis rs2976388 0.566 rs13250661 chr8:143804134 C/T cg05569086 chr8:143859399 LYNX1 -0.43 -7.01 -0.36 1.34e-11 Urinary tract infection frequency; CRC cis rs9811920 0.638 rs704581 chr3:99556160 A/T cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G -0.45 -6.0 -0.31 5.16e-9 Axial length; CRC cis rs747650 0.926 rs10838659 chr11:47148210 C/T cg19486271 chr11:47235900 DDB2 -0.49 -7.53 -0.38 4.81e-13 Acne (severe); CRC cis rs3741404 0.584 rs645461 chr11:63893694 C/T cg18225595 chr11:63971243 STIP1 -0.51 -8.2 -0.41 5.44e-15 Platelet count; CRC cis rs6502050 0.805 rs9915071 chr17:80119138 T/C cg19223190 chr17:80058835 NA 0.39 6.23 0.32 1.43e-9 Life satisfaction; CRC cis rs41271473 0.526 rs2182202 chr1:228733959 G/C cg16512390 chr1:228756714 NA 0.64 6.8 0.35 4.93e-11 Chronic lymphocytic leukemia; CRC cis rs559928 0.606 rs55970968 chr11:63961433 C/T cg19465662 chr11:63993652 NUDT22;TRPT1 0.7 6.66 0.34 1.12e-10 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; CRC cis rs10871290 0.650 rs28484753 chr16:74489395 G/C cg01733217 chr16:74700730 RFWD3 0.77 12.3 0.56 7.34e-29 Breast cancer; CRC cis rs951366 0.668 rs823154 chr1:205762406 C/T cg26354017 chr1:205819088 PM20D1 0.86 14.09 0.61 1.33e-35 Menarche (age at onset); CRC cis rs780096 0.506 rs1647285 chr2:27714511 A/C cg12000995 chr2:27665139 KRTCAP3 -0.34 -7.17 -0.37 4.95e-12 Total body bone mineral density; CRC cis rs9486719 1.000 rs11153018 chr6:96956137 G/A cg06623918 chr6:96969491 KIAA0776 -0.79 -9.12 -0.45 7.75e-18 Migraine;Coronary artery disease; CRC cis rs780096 0.587 rs6743819 chr2:27567407 G/T cg02592271 chr2:27665507 KRTCAP3 -0.27 -6.11 -0.32 2.81e-9 Total body bone mineral density; CRC cis rs57994353 0.897 rs35526483 chr9:139364940 G/A cg14119001 chr9:139324193 INPP5E -0.45 -6.43 -0.33 4.55e-10 Eosinophil counts;Cutaneous squamous cell carcinoma; CRC cis rs6570726 0.967 rs441364 chr6:145853662 G/C cg05347473 chr6:146136440 FBXO30 0.4 6.25 0.33 1.31e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs1552244 0.554 rs2272120 chr3:10046703 C/T cg00166722 chr3:10149974 C3orf24 0.43 6.37 0.33 6.32e-10 Alzheimer's disease; CRC cis rs1656402 1.000 rs1190439 chr2:233422390 G/A cg03852847 chr2:233439513 NA 0.45 7.71 0.39 1.54e-13 Non-small cell lung cancer (survival); CRC cis rs2688608 0.592 rs11814282 chr10:75490217 T/C cg00564723 chr10:75632066 CAMK2G -0.22 -5.61 -0.3 4.35e-8 Inflammatory bowel disease; CRC cis rs7809950 1.000 rs2520268 chr7:107191161 T/A cg23024343 chr7:107201750 COG5 -0.64 -9.06 -0.45 1.16e-17 Coronary artery disease; CRC cis rs3733585 0.605 rs56178126 chr4:10123581 C/T cg11266682 chr4:10021025 SLC2A9 -0.47 -8.37 -0.42 1.64e-15 Cleft plate (environmental tobacco smoke interaction); CRC trans rs10504229 1.000 rs67895971 chr8:58177994 A/G cg04077850 chr5:125800366 GRAMD3 0.37 6.27 0.33 1.15e-9 Developmental language disorder (linguistic errors); CRC cis rs798554 0.679 rs2266922 chr7:2824707 G/A cg17321639 chr7:2759063 NA -0.37 -5.63 -0.3 3.94e-8 Height; CRC cis rs35883536 0.647 rs12023028 chr1:101042717 C/T cg06223162 chr1:101003688 GPR88 -0.36 -6.62 -0.34 1.44e-10 Monocyte count; CRC cis rs11758351 0.866 rs75091077 chr6:26207546 A/C cg01420254 chr6:26195488 NA 0.81 9.22 0.45 3.53e-18 Gout;Renal underexcretion gout; CRC trans rs9650657 0.707 rs4841452 chr8:10687121 A/G cg06636001 chr8:8085503 FLJ10661 -0.48 -6.99 -0.36 1.57e-11 Neuroticism; CRC cis rs2739330 0.587 rs4820571 chr22:24242973 A/G cg11905131 chr22:24372483 LOC391322 -0.51 -7.37 -0.38 1.39e-12 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs7666738 0.861 rs28821920 chr4:98962743 T/C cg17366294 chr4:99064904 C4orf37 0.43 7.36 0.38 1.49e-12 Colonoscopy-negative controls vs population controls; CRC cis rs9894429 0.538 rs9747080 chr17:79606704 A/G cg21984481 chr17:79567631 NPLOC4 -0.49 -8.98 -0.44 2.2e-17 Eye color traits; CRC cis rs2404602 0.692 rs60658665 chr15:77042508 T/C cg23625390 chr15:77176239 SCAPER 0.48 6.83 0.35 4.16e-11 Blood metabolite levels; CRC cis rs4132509 1.000 rs7534117 chr1:243964902 A/C cg21452805 chr1:244014465 NA -0.46 -6.27 -0.33 1.14e-9 RR interval (heart rate); CRC cis rs2727020 0.521 rs1909220 chr11:49572109 T/C cg27395922 chr11:50257633 LOC441601 -0.36 -5.77 -0.3 1.86e-8 Coronary artery disease; CRC cis rs10791097 0.694 rs6590520 chr11:130747386 C/G cg12179176 chr11:130786555 SNX19 0.75 12.65 0.57 3.7e-30 Autism spectrum disorder or schizophrenia;Schizophrenia; CRC trans rs34421088 0.576 rs2736369 chr8:11101398 G/A cg06636001 chr8:8085503 FLJ10661 -0.47 -6.36 -0.33 6.56e-10 Neuroticism; CRC trans rs875971 0.545 rs75577046 chr7:65958716 A/G cg02869306 chr7:64672164 INTS4L1 -0.44 -6.34 -0.33 7.74e-10 Aortic root size; CRC cis rs4654899 1.000 rs61117207 chr1:21394374 A/C cg02927042 chr1:21476669 EIF4G3 -0.49 -7.78 -0.39 9.65e-14 Superior frontal gyrus grey matter volume; CRC cis rs995000 0.931 rs638714 chr1:62906489 G/T cg19896129 chr1:63156450 NA 0.4 6.17 0.32 2.03e-9 Triglyceride levels; CRC cis rs7584330 0.666 rs72620817 chr2:238353661 C/T cg14458575 chr2:238380390 NA 0.9 15.94 0.66 8.83e-43 Prostate cancer; CRC cis rs10751667 0.643 rs12278229 chr11:946985 A/G cg06064525 chr11:970664 AP2A2 -0.34 -6.99 -0.36 1.55e-11 Alzheimer's disease (late onset); CRC cis rs7572644 0.699 rs10194283 chr2:28159079 G/A cg27432699 chr2:27873401 GPN1 -0.4 -5.6 -0.3 4.45e-8 Response to carboplatin and paclitaxel in ovarian cancer (Caspase 3/7 EC50); CRC cis rs9311474 0.597 rs13303 chr3:52558008 T/C cg07507251 chr3:52567010 NT5DC2 0.5 7.79 0.39 8.64e-14 Electroencephalogram traits; CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg22225685 chr22:38203998 GCAT 0.39 6.29 0.33 1.02e-9 Obesity-related traits; CRC cis rs10504229 0.600 rs6987243 chr8:58115406 T/C cg05313129 chr8:58192883 C8orf71 -0.43 -6.11 -0.32 2.74e-9 Developmental language disorder (linguistic errors); CRC cis rs13118159 0.509 rs7688922 chr4:1361011 T/C cg20887711 chr4:1340912 KIAA1530 0.76 11.03 0.52 2.84e-24 Longevity; CRC cis rs832540 0.931 rs832529 chr5:56229288 C/T cg24531977 chr5:56204891 C5orf35 -0.49 -7.58 -0.39 3.49e-13 Coronary artery disease; CRC cis rs4692589 1.000 rs1871683 chr4:170937348 T/C cg19918862 chr4:170955249 NA 0.38 6.26 0.33 1.18e-9 Anxiety disorder; CRC cis rs28386778 0.863 rs4968661 chr17:61796306 A/G cg22520471 chr17:61851767 DDX42;CCDC47 0.72 11.13 0.52 1.28e-24 Prudent dietary pattern; CRC cis rs2243480 1.000 rs1404147 chr7:65264524 C/T cg12463550 chr7:65579703 CRCP 0.6 6.17 0.32 2.05e-9 Diabetic kidney disease; CRC trans rs1908814 0.510 rs57655799 chr8:11782417 A/C cg08975724 chr8:8085496 FLJ10661 0.41 6.4 0.33 5.39e-10 Neuroticism; CRC cis rs9814567 1.000 rs4974484 chr3:134219019 C/T cg06109529 chr3:134205091 CEP63;ANAPC13 -0.82 -12.23 -0.56 1.32e-28 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs2645694 0.626 rs2645709 chr4:77824474 G/A cg06046430 chr4:77819534 ANKRD56 0.4 5.63 0.3 3.94e-8 Emphysema distribution in smoking; CRC cis rs9611565 0.512 rs5758465 chr22:42175314 T/C cg06481639 chr22:41940642 POLR3H 0.55 6.05 0.32 3.97e-9 Vitiligo; CRC cis rs6963495 0.745 rs818620 chr7:105172685 G/C cg02135003 chr7:105160482 PUS7 -0.68 -10.13 -0.49 3.59e-21 Bipolar disorder (body mass index interaction); CRC cis rs1552244 1.000 rs7652935 chr3:10151138 T/C cg00166722 chr3:10149974 C3orf24 0.69 9.16 0.45 5.63e-18 Alzheimer's disease; CRC cis rs11148252 0.904 rs9568734 chr13:53004222 G/A cg12458913 chr13:53173898 NA 0.59 9.36 0.46 1.34e-18 Lewy body disease; CRC cis rs877282 0.842 rs35872126 chr10:764545 G/A cg17470449 chr10:769945 NA 0.66 8.48 0.42 7.57e-16 Uric acid levels; CRC cis rs6951245 0.872 rs77569514 chr7:1085508 G/A cg26224354 chr7:1096374 C7orf50;GPR146 -0.89 -11.23 -0.53 5.33e-25 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs7113874 0.524 rs4244804 chr11:8617550 C/T cg02811074 chr11:8615871 STK33 0.33 5.76 0.3 1.97e-8 Body mass index in physically active individuals;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs7737355 0.947 rs251014 chr5:131029463 A/G cg06307176 chr5:131281290 NA 0.42 6.23 0.32 1.43e-9 Life satisfaction; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg17860381 chr5:142783569 NR3C1 0.29 6.27 0.33 1.1e-9 Liver disease severity in Alagille syndrome; CRC cis rs9787249 0.957 rs56064244 chr1:40213890 C/T cg02773041 chr1:40204384 PPIE 0.64 9.5 0.46 4.57e-19 Blood protein levels; CRC trans rs10242455 0.557 rs73401516 chr7:99068351 C/A cg09045935 chr12:6379348 NA 1.13 9.12 0.45 7.59e-18 Blood metabolite levels; CRC cis rs10504229 0.683 rs56204590 chr8:58131642 T/G cg02725872 chr8:58115012 NA -0.64 -11.55 -0.54 3.85e-26 Developmental language disorder (linguistic errors); CRC cis rs7209700 0.662 rs8080254 chr17:45347892 C/G cg17185639 chr17:45330862 ITGB3 -0.36 -5.95 -0.31 7.02e-9 IgG glycosylation; CRC cis rs6951245 1.000 rs11761941 chr7:1097183 G/A cg24642844 chr7:1081250 C7orf50 -0.76 -9.16 -0.45 5.78e-18 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs28386778 0.831 rs2584618 chr17:61923611 T/C cg06873352 chr17:61820015 STRADA 0.79 15.0 0.64 4.13e-39 Prudent dietary pattern; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg14813019 chr8:90996956 NBN 0.45 6.26 0.33 1.19e-9 Response to antipsychotic treatment; CRC cis rs9894429 0.966 rs7405901 chr17:79587813 T/C cg21028142 chr17:79581711 NPLOC4 0.39 8.62 0.43 2.89e-16 Eye color traits; CRC cis rs6500602 1.000 rs11647946 chr16:4462836 G/A cg14951292 chr16:4525986 HMOX2;NMRAL1 0.51 7.23 0.37 3.45e-12 Schizophrenia; CRC cis rs7197653 0.748 rs8063446 chr16:68344363 A/C cg09835421 chr16:68378352 PRMT7 -0.8 -7.63 -0.39 2.55e-13 Magnesium levels; CRC trans rs12310956 0.532 rs1352211 chr12:33983132 G/A cg26384229 chr12:38710491 ALG10B 0.47 6.28 0.33 1.06e-9 Morning vs. evening chronotype; CRC cis rs9394438 0.529 rs10947681 chr6:37547073 C/A cg00985040 chr6:37553208 NA -0.46 -7.57 -0.39 3.79e-13 IgG glycosylation; CRC trans rs2727020 0.595 rs10839286 chr11:49497063 C/A cg11707556 chr5:10655725 ANKRD33B -0.4 -7.58 -0.39 3.59e-13 Coronary artery disease; CRC trans rs561341 0.883 rs72821942 chr17:30234460 C/T cg27661571 chr11:113659931 NA -0.67 -7.64 -0.39 2.4e-13 Hip circumference adjusted for BMI; CRC cis rs7617773 1.000 rs7617773 chr3:48193515 C/T cg11946769 chr3:48343235 NME6 -0.49 -6.61 -0.34 1.56e-10 Coronary artery disease; CRC cis rs2991971 0.967 rs10789465 chr1:45971759 T/C cg24296786 chr1:45957014 TESK2 0.55 8.27 0.41 3.28e-15 High light scatter reticulocyte count; CRC cis rs3617 0.625 rs7617468 chr3:52849549 T/C cg15147215 chr3:52552868 STAB1 -0.53 -9.09 -0.45 9.2e-18 Red blood cell count;Autism spectrum disorder or schizophrenia; CRC cis rs10504229 0.683 rs6980850 chr8:58127204 A/G cg22535103 chr8:58192502 C8orf71 -0.7 -9.34 -0.46 1.47e-18 Developmental language disorder (linguistic errors); CRC cis rs9916302 0.904 rs8066704 chr17:37477218 C/T cg00129232 chr17:37814104 STARD3 0.53 7.92 0.4 3.57e-14 Glomerular filtration rate (creatinine); CRC cis rs72781680 0.821 rs11894756 chr2:24170214 A/G cg08917208 chr2:24149416 ATAD2B -0.56 -6.76 -0.35 6.43e-11 Lymphocyte counts; CRC trans rs8073060 0.544 rs225244 chr17:33946581 A/G cg19694781 chr19:47549865 TMEM160 1.0 14.23 0.62 3.96e-36 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; CRC cis rs11264799 0.639 rs6677622 chr1:157751356 C/T cg11810135 chr1:157771971 FCRL1 0.38 5.91 0.31 8.51e-9 IgA nephropathy; CRC cis rs9916302 0.904 rs9892055 chr17:37510402 C/T cg00129232 chr17:37814104 STARD3 0.54 7.93 0.4 3.52e-14 Glomerular filtration rate (creatinine); CRC cis rs3750082 0.692 rs10248993 chr7:32927147 A/G cg05721444 chr7:32995514 FKBP9 0.52 6.65 0.34 1.22e-10 Glomerular filtration rate (creatinine); CRC cis rs4974559 0.641 rs28647383 chr4:1312908 G/C cg02980000 chr4:1222292 CTBP1 0.71 7.79 0.39 8.83e-14 Systolic blood pressure; CRC cis rs13108904 0.967 rs900027 chr4:1279360 G/A cg16405210 chr4:1374714 KIAA1530 -0.46 -6.25 -0.33 1.27e-9 Obesity-related traits; CRC cis rs1728785 1.000 rs1728789 chr16:68595776 C/T cg02972257 chr16:68554789 NA -0.6 -7.54 -0.38 4.71e-13 Ulcerative colitis; CRC cis rs789852 0.867 rs6437391 chr3:194316826 C/T cg21106136 chr3:194405973 FAM43A -0.74 -6.17 -0.32 2.06e-9 QT interval; CRC cis rs875971 0.862 rs6959268 chr7:65812966 G/A cg00343986 chr7:65444356 GUSB -0.4 -5.66 -0.3 3.3e-8 Aortic root size; CRC cis rs6912958 0.514 rs7767449 chr6:87887985 A/C cg08069147 chr6:88032118 GJB7;C6orf162 -0.71 -11.57 -0.54 3.45e-26 Monocyte percentage of white cells; CRC cis rs853679 0.517 rs9393894 chr6:28112562 A/G cg06470822 chr6:28175283 NA 1.03 13.59 0.6 1.04e-33 Depression; CRC cis rs7618501 0.602 rs9311446 chr3:50092226 G/A cg24110177 chr3:50126178 RBM5 0.48 7.24 0.37 3.13e-12 Intelligence (multi-trait analysis); CRC cis rs6840360 0.582 rs2709826 chr4:152332120 G/T cg09659197 chr4:152720779 NA 0.29 5.65 0.3 3.42e-8 Intelligence (multi-trait analysis); CRC cis rs1448094 0.512 rs6539927 chr12:86244486 T/C cg02569458 chr12:86230093 RASSF9 0.42 7.23 0.37 3.48e-12 Major depressive disorder; CRC cis rs9733 0.596 rs72702573 chr1:150689050 C/T cg17724175 chr1:150552817 MCL1 0.57 9.12 0.45 7.76e-18 Tonsillectomy; CRC cis rs12760731 0.516 rs12403484 chr1:178129059 C/A cg00404053 chr1:178313656 RASAL2 1.08 11.31 0.53 2.77e-25 Obesity-related traits; CRC cis rs13118159 0.872 rs4974605 chr4:1346389 C/G cg02018176 chr4:1364513 KIAA1530 0.4 6.56 0.34 2.14e-10 Longevity; CRC cis rs514406 0.621 rs1930306 chr1:53195686 C/G cg08859206 chr1:53392774 SCP2 0.43 6.75 0.35 6.84e-11 Monocyte count; CRC cis rs6582630 0.519 rs11514078 chr12:38408817 G/C cg13010199 chr12:38710504 ALG10B 0.47 6.15 0.32 2.24e-9 Drug-induced liver injury (flucloxacillin); CRC cis rs1552244 0.882 rs17050699 chr3:10037167 G/A cg13047869 chr3:10149882 C3orf24 0.51 6.97 0.36 1.74e-11 Alzheimer's disease; CRC cis rs989128 0.642 rs7214956 chr17:48627148 G/C cg16068336 chr17:48637367 CACNA1G -0.54 -7.73 -0.39 1.36e-13 Type 2 diabetes; CRC cis rs2832191 0.791 rs2832187 chr21:30485543 T/C cg08807101 chr21:30365312 RNF160 -0.65 -10.67 -0.51 5.23e-23 Dental caries; CRC cis rs6860806 0.661 rs6871350 chr5:131580220 A/G cg12564285 chr5:131593104 PDLIM4 0.48 9.29 0.46 2.13e-18 Breast cancer; CRC cis rs2032447 0.832 rs10425 chr6:26056549 A/G cg12588279 chr6:26043732 HIST1H2BB 0.43 6.29 0.33 1.01e-9 Intelligence (multi-trait analysis); CRC cis rs4843747 0.671 rs8062855 chr16:88106941 T/C cg07865391 chr16:88106882 BANP 0.46 6.05 0.32 3.86e-9 Menopause (age at onset); CRC cis rs17401966 0.964 rs6674843 chr1:10458378 A/T cg19773385 chr1:10388646 KIF1B -0.45 -6.07 -0.32 3.54e-9 Hepatocellular carcinoma; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg19905802 chr11:62554200 TMEM179B;TAF6L 0.39 6.47 0.34 3.62e-10 Liver disease severity in Alagille syndrome; CRC cis rs7811142 1.000 rs2406255 chr7:100053690 T/C cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.18 16.63 0.68 1.69e-45 Platelet count; CRC cis rs1814175 0.519 rs10839291 chr11:49514321 G/A cg25886479 chr11:50257625 LOC441601 0.34 5.63 0.3 3.83e-8 Height; CRC cis rs10504229 0.638 rs7826839 chr8:58132075 G/T cg02290350 chr8:58132656 NA -0.58 -8.16 -0.41 7.29e-15 Developmental language disorder (linguistic errors); CRC cis rs7680126 0.633 rs4697743 chr4:10294833 A/G cg11266682 chr4:10021025 SLC2A9 -0.42 -6.46 -0.34 3.86e-10 Urate levels in lean individuals;Urate levels in overweight individuals;Urate levels in obese individuals; CRC cis rs6831352 0.879 rs29001196 chr4:100054116 C/T cg12011299 chr4:100065546 ADH4 -0.49 -9.27 -0.45 2.61e-18 Alcohol dependence; CRC cis rs7274811 0.744 rs6141962 chr20:32110312 T/C cg07470512 chr20:32255052 NECAB3;C20orf134 -0.45 -5.98 -0.31 5.84e-9 Height; CRC cis rs13191362 0.507 rs1079020 chr6:163066596 C/T cg21926612 chr6:163149169 PACRG;PARK2 -0.61 -9.29 -0.46 2.22e-18 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC trans rs1814175 0.653 rs10839480 chr11:50034556 C/T cg15704280 chr7:45808275 SEPT13 -0.97 -19.11 -0.73 2.72e-55 Height; CRC cis rs9372498 0.536 rs62422229 chr6:118959288 T/C cg24463073 chr6:118973353 C6orf204 0.48 6.3 0.33 9.45e-10 Diastolic blood pressure; CRC cis rs6121246 0.559 rs6119728 chr20:30413121 G/A cg13852791 chr20:30311386 BCL2L1 0.75 14.9 0.63 9.8e-39 Mean corpuscular hemoglobin; CRC cis rs6963495 0.818 rs118134111 chr7:105161229 A/C cg13798780 chr7:105162888 PUS7 0.68 8.08 0.41 1.27e-14 Bipolar disorder (body mass index interaction); CRC cis rs8141529 0.764 rs8137969 chr22:29228484 G/C cg15103426 chr22:29168792 CCDC117 0.59 8.61 0.43 3e-16 Lymphocyte counts; CRC cis rs7193541 0.965 rs8050262 chr16:74661159 T/C cg01733217 chr16:74700730 RFWD3 0.86 15.83 0.66 2.39e-42 Multiple myeloma; CRC cis rs7618915 0.571 rs6762457 chr3:52609157 G/A cg18404041 chr3:52824283 ITIH1 -0.42 -8.75 -0.43 1.13e-16 Bipolar disorder; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg23996948 chr1:61548526 NFIA 0.38 6.21 0.32 1.63e-9 Liver disease severity in Alagille syndrome; CRC cis rs4243830 0.850 rs932112 chr1:6591937 A/G cg15205204 chr1:6545172 PLEKHG5 0.38 5.61 0.3 4.31e-8 Body mass index; CRC cis rs644799 0.965 rs11021305 chr11:95498269 A/G cg25622487 chr11:95524042 FAM76B;CEP57 0.77 11.75 0.54 7.43e-27 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs73200209 0.701 rs61939684 chr12:116509365 G/A cg01776926 chr12:116560359 MED13L -0.64 -7.35 -0.38 1.57e-12 Total body bone mineral density; CRC cis rs7843479 0.601 rs1031882 chr8:21788934 T/G cg16476235 chr8:21771668 DOK2 0.38 6.21 0.32 1.62e-9 Mean corpuscular volume; CRC cis rs3806843 0.547 rs246065 chr5:140323638 A/G cg19875535 chr5:140030758 IK 0.39 6.02 0.31 4.67e-9 Depressive symptoms (multi-trait analysis); CRC cis rs8180040 0.800 rs2088135 chr3:47280018 T/C cg10298567 chr3:47292165 KIF9 0.41 6.38 0.33 5.89e-10 Colorectal cancer; CRC cis rs1348850 0.757 rs2166554 chr2:178455824 A/G cg22681709 chr2:178499509 PDE11A -0.32 -6.03 -0.32 4.32e-9 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC trans rs10983614 1.000 rs7867776 chr9:120072627 A/G cg01525244 chr22:39548611 CBX7 0.5 6.68 0.35 1e-10 Survival in pancreatic cancer; CRC cis rs1223397 1.000 rs1223399 chr6:13271220 G/A cg07912922 chr6:13274314 PHACTR1 0.49 6.09 0.32 3.08e-9 Blood pressure; CRC cis rs9443645 0.868 rs9443643 chr6:79798838 A/G cg05283184 chr6:79620031 NA -0.59 -9.28 -0.46 2.37e-18 Intelligence (multi-trait analysis); CRC cis rs13256369 1.000 rs885000 chr8:8568875 G/T cg17143192 chr8:8559678 CLDN23 0.49 6.34 0.33 7.76e-10 Obesity-related traits; CRC cis rs2239547 0.522 rs6792578 chr3:53004604 G/A cg11645453 chr3:52864694 ITIH4 0.52 9.17 0.45 5.4e-18 Schizophrenia; CRC cis rs801193 0.844 rs2244022 chr7:66202430 A/G cg00343986 chr7:65444356 GUSB 0.46 6.82 0.35 4.49e-11 Aortic root size; CRC cis rs11969893 0.850 rs9390697 chr6:101294431 G/A cg12253828 chr6:101329408 ASCC3 1.14 8.76 0.43 1.03e-16 Economic and political preferences (immigration/crime); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg17267720 chr15:34396248 PGBD4 -0.37 -6.26 -0.33 1.22e-9 Liver disease severity in Alagille syndrome; CRC cis rs7727544 0.735 rs272881 chr5:131669264 G/A cg12564285 chr5:131593104 PDLIM4 0.31 5.64 0.3 3.69e-8 Blood metabolite levels; CRC cis rs9682041 0.627 rs4955722 chr3:170102959 G/T cg11886554 chr3:170076028 SKIL 0.7 8.29 0.42 2.98e-15 Glomerular filtration rate in non diabetics (creatinine);Glomerular filtration rate (creatinine); CRC cis rs2153535 0.601 rs9505474 chr6:8539794 C/G cg21535247 chr6:8435926 SLC35B3 0.5 7.72 0.39 1.45e-13 Motion sickness; CRC cis rs7044106 0.762 rs4837790 chr9:123446325 C/T cg09419670 chr9:123605666 PSMD5;LOC253039 0.7 11.54 0.54 4.41e-26 Hip circumference adjusted for BMI; CRC trans rs7395662 0.525 rs1945189 chr11:48418889 A/G cg03929089 chr4:120376271 NA -0.46 -6.6 -0.34 1.65e-10 HDL cholesterol; CRC cis rs10840133 1 rs10840133 chr11:8846369 G/A cg00186954 chr11:8933980 ST5;C11orf17 0.38 6.09 0.32 3.11e-9 Reticulocyte fraction of red cells; CRC cis rs9916302 0.800 rs8069451 chr17:37504933 C/T cg00129232 chr17:37814104 STARD3 -0.52 -7.68 -0.39 1.79e-13 Glomerular filtration rate (creatinine); CRC cis rs12143943 0.966 rs3789047 chr1:204586184 A/G cg17419461 chr1:204415978 PIK3C2B 0.4 6.18 0.32 1.91e-9 Cognitive performance; CRC cis rs25422 0.938 rs7356858 chr6:118765814 G/C cg07617317 chr6:118971624 C6orf204 0.52 6.47 0.34 3.53e-10 Renal cell carcinoma; CRC cis rs9322193 0.923 rs9767309 chr6:150037943 A/G cg05861140 chr6:150128134 PCMT1 -0.37 -5.96 -0.31 6.32e-9 Lung cancer; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg20623943 chr1:47799834 CMPK1 0.53 7.59 0.39 3.33e-13 Response to antipsychotic treatment; CRC trans rs9858542 0.953 rs6779524 chr3:49450449 C/T cg21659725 chr3:3221576 CRBN -0.65 -8.99 -0.44 1.94e-17 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs7809950 0.678 rs6949634 chr7:106984684 G/T cg23024343 chr7:107201750 COG5 -0.73 -9.87 -0.48 2.76e-20 Coronary artery disease; CRC cis rs7781557 0.640 rs2228687 chr7:102616469 G/A cg18108683 chr7:102477205 FBXL13 0.5 5.96 0.31 6.42e-9 Colorectal adenoma (advanced); CRC cis rs6570726 1.000 rs374464 chr6:145846679 A/C cg05347473 chr6:146136440 FBXO30 0.38 6.06 0.32 3.73e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs2880765 0.527 rs35184622 chr15:86073035 A/G cg20737812 chr15:86336631 KLHL25 -0.35 -5.67 -0.3 3.05e-8 Coronary artery disease; CRC cis rs9393777 0.513 rs13195210 chr6:26646521 C/T cg12292205 chr6:26970375 C6orf41 -0.61 -6.92 -0.36 2.3e-11 Intelligence (multi-trait analysis); CRC cis rs2274273 0.934 rs8021940 chr14:55719715 G/A cg23234261 chr14:55582407 NA -0.29 -5.7 -0.3 2.69e-8 Protein biomarker; CRC cis rs11976180 0.569 rs12703565 chr7:143754401 C/T cg10928931 chr7:144051247 ARHGEF5 0.46 5.64 0.3 3.75e-8 Obesity-related traits; CRC cis rs7927771 0.524 rs4752798 chr11:47886364 T/C cg20307385 chr11:47447363 PSMC3 -0.45 -6.68 -0.35 9.91e-11 Subjective well-being; CRC cis rs9393692 0.875 rs9358917 chr6:26284417 T/C cg00631329 chr6:26305371 NA -0.68 -13.44 -0.6 3.92e-33 Educational attainment; CRC cis rs9322193 0.847 rs4870054 chr6:150169538 C/T cg05861140 chr6:150128134 PCMT1 -0.42 -6.5 -0.34 2.99e-10 Lung cancer; CRC cis rs11676348 0.846 rs4674260 chr2:219002376 T/C cg00012203 chr2:219082015 ARPC2 -0.43 -6.44 -0.33 4.21e-10 Ulcerative colitis; CRC cis rs853679 0.517 rs1947863 chr6:28099344 G/A cg21251018 chr6:28226885 NKAPL 0.48 6.33 0.33 7.86e-10 Depression; CRC cis rs7811142 1.000 rs7783550 chr7:99987805 A/G cg07160278 chr7:100027354 MEPCE;ZCWPW1 -1.1 -16.39 -0.67 1.49e-44 Platelet count; CRC cis rs66731853 0.771 rs541244 chr1:20889380 G/A cg04087271 chr1:20915334 CDA -0.34 -5.91 -0.31 8.51e-9 Mean corpuscular volume; CRC cis rs1799949 1.000 rs4793229 chr17:41418334 C/T cg23758822 chr17:41437982 NA -0.8 -13.52 -0.6 1.97e-33 Menopause (age at onset); CRC cis rs11098499 0.820 rs28535956 chr4:120536858 C/T cg24375607 chr4:120327624 NA -0.48 -7.18 -0.37 4.53e-12 Corneal astigmatism; CRC cis rs10256972 0.516 rs12702081 chr7:1141528 T/C cg04025307 chr7:1156635 C7orf50 0.75 12.51 0.57 1.26e-29 Longevity;Endometriosis; CRC cis rs317689 0.819 rs317660 chr12:69686203 G/A cg14784868 chr12:69753453 YEATS4 0.44 5.72 0.3 2.43e-8 Response to diuretic therapy; CRC cis rs4731207 0.698 rs13228116 chr7:124480506 A/G cg23710748 chr7:124431027 NA 0.38 6.08 0.32 3.28e-9 Cutaneous malignant melanoma; CRC cis rs514406 0.584 rs7548832 chr1:53193576 A/T cg25767906 chr1:53392781 SCP2 -0.41 -6.57 -0.34 1.92e-10 Monocyte count; CRC cis rs7236492 0.505 rs11663549 chr18:77181989 A/G cg15644404 chr18:77186268 NFATC1 0.73 7.01 0.36 1.36e-11 Inflammatory bowel disease;Crohn's disease; CRC cis rs1395 0.710 rs2083363 chr2:27475318 G/C cg23587288 chr2:27483067 SLC30A3 -0.4 -6.74 -0.35 7.29e-11 Blood metabolite levels; CRC cis rs1552244 0.882 rs28366039 chr3:10028988 C/A cg16606324 chr3:10149918 C3orf24 0.57 6.91 0.36 2.47e-11 Alzheimer's disease; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg22886643 chr4:159690732 FNIP2 0.42 6.05 0.32 4.04e-9 Intelligence (multi-trait analysis); CRC cis rs947211 0.950 rs1775145 chr1:205756143 C/A cg24503407 chr1:205819492 PM20D1 0.46 6.31 0.33 9.22e-10 Parkinson's disease; CRC cis rs898097 0.691 rs7222745 chr17:80907253 C/T cg15664640 chr17:80829946 TBCD -0.48 -8.15 -0.41 7.84e-15 Breast cancer; CRC cis rs12701220 0.655 rs9638973 chr7:1133678 A/G cg02733842 chr7:1102375 C7orf50 -0.61 -7.46 -0.38 7.7e-13 Bronchopulmonary dysplasia; CRC trans rs2303319 0.504 rs62189051 chr2:162622318 G/A cg22627826 chr19:1240265 ATP5D -0.72 -6.24 -0.33 1.37e-9 Cognitive function; CRC cis rs3785888 0.548 rs11079744 chr17:45027119 A/T cg16759221 chr17:45003025 GOSR2 -0.71 -10.52 -0.5 1.7e-22 Cleft lip with or without cleft palate; CRC cis rs1008375 0.900 rs7658447 chr4:17579415 T/C cg16339924 chr4:17578868 LAP3 0.67 8.37 0.42 1.62e-15 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs4975709 0.610 rs4975705 chr5:1860359 T/C cg20790798 chr5:1857306 NA -0.44 -6.7 -0.35 8.93e-11 Cardiovascular disease risk factors; CRC cis rs58688157 0.660 rs7117022 chr11:583787 T/C cg03909863 chr11:638404 DRD4 -0.51 -6.87 -0.35 3.24e-11 Systemic lupus erythematosus; CRC cis rs9469578 0.792 rs73743331 chr6:33714036 G/T cg18708504 chr6:33715942 IP6K3 0.66 7.56 0.38 4e-13 Phosphorus levels; CRC cis rs2842992 0.789 rs2146163 chr6:160224346 T/C cg19482086 chr6:160211437 TCP1;MRPL18 0.74 9.59 0.47 2.24e-19 Age-related macular degeneration (geographic atrophy); CRC cis rs9368481 0.569 rs10946868 chr6:26887930 A/G cg18278486 chr6:26987575 LOC100270746;C6orf41 0.39 6.1 0.32 2.91e-9 Autism spectrum disorder or schizophrenia; CRC cis rs11155671 0.530 rs9968871 chr6:150209196 G/A cg07701084 chr6:150067640 NUP43 0.52 7.03 0.36 1.2e-11 Testicular germ cell tumor; CRC cis rs3785574 0.886 rs62077504 chr17:61837734 A/G cg11494091 chr17:61959527 GH2 0.38 5.93 0.31 7.63e-9 Height; CRC trans rs2303319 0.504 rs12467625 chr2:162603387 C/A cg22988483 chr14:93581567 ITPK1 -0.66 -6.07 -0.32 3.52e-9 Cognitive function; CRC cis rs9379850 0.730 rs9393738 chr6:26620658 G/A cg12292205 chr6:26970375 C6orf41 -0.6 -6.73 -0.35 7.52e-11 Intelligence (multi-trait analysis); CRC cis rs7635838 0.596 rs4684765 chr3:11261085 G/C cg00170343 chr3:11313890 ATG7 0.54 8.36 0.42 1.84e-15 HDL cholesterol; CRC cis rs6840360 1.000 rs6838966 chr4:152603475 C/T cg09659197 chr4:152720779 NA 0.52 11.15 0.52 1.01e-24 Intelligence (multi-trait analysis); CRC cis rs7223966 0.961 rs35844156 chr17:61837568 G/A cg05941027 chr17:61774174 LIMD2 0.35 6.02 0.31 4.7e-9 Hip circumference adjusted for BMI;Body mass index; CRC cis rs4700695 0.925 rs12653007 chr5:65396965 G/A cg21114390 chr5:65439923 SFRS12 -0.49 -6.35 -0.33 7.17e-10 Facial morphology (factor 19); CRC cis rs4819052 0.885 rs9980676 chr21:46665430 A/G cg11663144 chr21:46675770 NA -0.83 -14.13 -0.61 9.4e-36 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs1728785 1.000 rs698716 chr16:68560296 C/T cg02972257 chr16:68554789 NA -0.63 -7.21 -0.37 3.91e-12 Ulcerative colitis; CRC trans rs1814175 0.616 rs1722001 chr11:49894427 A/G cg11707556 chr5:10655725 ANKRD33B -0.52 -10.04 -0.48 7.17e-21 Height; CRC cis rs887829 0.569 rs3806597 chr2:234637569 C/T cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 0.44 7.02 0.36 1.29e-11 Metabolic traits;Bilirubin levels;Cholelithiasis-related traits in sickle cell anemia;Metabolite levels;Total bilirubin levels in HIV-1 infection;Serum metabolite levels;Blood metabolite levels; CRC cis rs9469913 0.542 rs3800461 chr6:34616322 G/C cg17674042 chr6:34482479 PACSIN1 -0.74 -7.13 -0.37 6.47e-12 Body mass index (joint analysis main effects and physical activity interaction);Body mass index;Body mass index in physically active individuals; CRC cis rs7772486 0.875 rs12194437 chr6:146411440 A/G cg13319975 chr6:146136371 FBXO30 -0.4 -6.17 -0.32 2.05e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs7385804 0.727 rs221790 chr7:100278282 G/C cg20848291 chr7:100343083 ZAN 0.49 7.61 0.39 2.9e-13 Iron status biomarkers;Mean corpuscular hemoglobin;Hematocrit;Iron status biomarkers (transferrin saturation);Red blood cell count;Iron status biomarkers (iron levels);Mean corpuscular volume;Hematological parameters; CRC cis rs6951245 0.872 rs112309216 chr7:1100296 A/T cg03188948 chr7:1209495 NA 0.65 6.84 0.35 3.8e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs17767392 0.645 rs55737377 chr14:71671426 C/T cg13720639 chr14:72061746 SIPA1L1 -0.48 -5.77 -0.3 1.8e-8 Mitral valve prolapse; CRC cis rs1185460 0.967 rs1177563 chr11:118949083 C/T cg23280166 chr11:118938394 VPS11 0.44 6.46 0.34 3.8e-10 Coronary artery disease; CRC cis rs4589502 0.800 rs4776855 chr15:67202075 T/C cg12317470 chr15:67143691 NA -0.53 -6.63 -0.34 1.37e-10 Lung cancer (smoking interaction); CRC cis rs9846480 0.598 rs3755751 chr3:138065567 A/G cg25476813 chr3:138050155 TXNDC6 -0.4 -5.89 -0.31 9.56e-9 Whole-brain volume (Alzheimer's disease interaction); CRC cis rs7772486 0.655 rs2142981 chr6:146071695 G/C cg05347473 chr6:146136440 FBXO30 -0.38 -5.71 -0.3 2.59e-8 Lobe attachment (rater-scored or self-reported); CRC cis rs6662572 0.703 rs11580953 chr1:46387857 A/G cg08644498 chr1:46502608 NA 0.44 7.0 0.36 1.45e-11 Blood protein levels; CRC cis rs7247513 0.790 rs17476839 chr19:12762783 C/T cg01871581 chr19:12707946 ZNF490 0.69 10.77 0.51 2.33e-23 Bipolar disorder; CRC cis rs9325144 0.600 rs1825807 chr12:38737007 T/C cg26384229 chr12:38710491 ALG10B 0.56 8.31 0.42 2.54e-15 Morning vs. evening chronotype; CRC cis rs9303280 0.901 rs2305479 chr17:38062217 C/T cg20243544 chr17:37824526 PNMT 0.46 7.17 0.37 5.04e-12 Self-reported allergy; CRC cis rs72781680 0.846 rs72780108 chr2:23986780 G/A cg08917208 chr2:24149416 ATAD2B 0.86 8.45 0.42 9.42e-16 Lymphocyte counts; CRC cis rs35123781 0.696 rs356433 chr5:139071193 C/T cg10513866 chr5:139070639 NA 0.54 8.31 0.42 2.51e-15 Schizophrenia; CRC cis rs10256972 0.630 rs13235747 chr7:1129123 T/C cg03923535 chr7:1197113 ZFAND2A 0.64 9.25 0.45 3.01e-18 Longevity;Endometriosis; CRC cis rs1862618 0.853 rs2432195 chr5:56120413 C/T cg03609598 chr5:56110824 MAP3K1 -0.85 -10.76 -0.51 2.44e-23 Initial pursuit acceleration; CRC cis rs13082711 0.911 rs73046191 chr3:27454398 T/A cg02860705 chr3:27208620 NA 0.59 8.55 0.43 4.66e-16 Systolic blood pressure;Diastolic blood pressure;Blood pressure; CRC cis rs11785400 1.000 rs3735994 chr8:143742683 C/T cg10596483 chr8:143751796 JRK 0.49 6.94 0.36 2.06e-11 Schizophrenia; CRC cis rs7814319 0.646 rs938828 chr8:97316821 A/C cg20787634 chr8:97240163 UQCRB -0.43 -6.94 -0.36 2.05e-11 Lung function (FVC); CRC cis rs11153730 0.503 rs283049 chr6:118635122 G/C cg15382696 chr6:118971807 C6orf204 -0.38 -5.81 -0.31 1.44e-8 QT interval;Heart rate;QRS duration;QRS complex (Sokolow-Lyon); CRC cis rs1801251 1.000 rs283474 chr2:233654627 A/G cg25237894 chr2:233734115 C2orf82 0.56 9.06 0.45 1.15e-17 Coronary artery disease; CRC cis rs28386778 0.829 rs1877317 chr17:61776479 T/C cg25654072 chr17:61904446 PSMC5;FTSJ3 0.75 11.42 0.53 1.14e-25 Prudent dietary pattern; CRC cis rs10986311 0.802 rs2416 chr9:127113660 A/G cg14243010 chr9:127117328 LOC100129034;PSMB7 0.42 6.35 0.33 7.03e-10 Vitiligo; CRC cis rs449789 0.817 rs534519 chr6:159711929 A/C cg14500486 chr6:159655392 FNDC1 -0.48 -7.29 -0.37 2.38e-12 Pulse pressure; CRC cis rs4481887 0.927 rs12731721 chr1:248474210 G/A cg00666640 chr1:248458726 OR2T12 0.45 7.8 0.4 8.31e-14 Common traits (Other); CRC cis rs477692 0.699 rs576175 chr10:131386408 A/T cg05714579 chr10:131428358 MGMT 0.46 6.62 0.34 1.46e-10 Response to temozolomide; CRC cis rs514406 0.929 rs557847 chr1:53333116 A/G cg25767906 chr1:53392781 SCP2 -0.44 -7.16 -0.37 5.15e-12 Monocyte count; CRC cis rs747650 0.504 rs2087215 chr11:47144542 A/C cg19486271 chr11:47235900 DDB2 0.44 5.67 0.3 3.2e-8 Acne (severe); CRC cis rs66573146 0.656 rs66905212 chr4:6949508 G/C cg00086871 chr4:6988644 TBC1D14 0.9 7.74 0.39 1.2e-13 Granulocyte percentage of myeloid white cells; CRC trans rs2797160 1.000 rs78602343 chr6:126019768 T/C cg05039488 chr6:79577232 IRAK1BP1 0.5 7.41 0.38 1.07e-12 Endometrial cancer; CRC cis rs801193 0.569 rs13242290 chr7:66121885 G/A cg18252515 chr7:66147081 NA 0.43 6.05 0.32 3.88e-9 Aortic root size; CRC trans rs561341 0.941 rs501773 chr17:30314435 T/G cg27661571 chr11:113659931 NA -0.77 -9.65 -0.47 1.43e-19 Hip circumference adjusted for BMI; CRC trans rs4843747 0.671 rs72818577 chr16:88111181 G/A cg26811252 chr16:29126840 RRN3P2 0.62 8.58 0.43 3.82e-16 Menopause (age at onset); CRC cis rs11758351 0.660 rs55643278 chr6:26222888 C/A cg08260959 chr6:26240920 HIST1H4F -0.35 -5.67 -0.3 3.2e-8 Gout;Renal underexcretion gout; CRC trans rs6703335 0.870 rs10803142 chr1:243598234 A/G cg05902173 chr6:139013757 NA 0.44 6.24 0.33 1.37e-9 Schizophrenia;Schizophrenia, schizoaffective disorder or bipolar disorder; CRC cis rs7811142 0.830 rs73401443 chr7:99977582 T/G cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.14 17.15 0.69 1.5e-47 Platelet count; CRC cis rs6762 0.748 rs5030780 chr11:838110 C/T cg15787769 chr11:842744 TSPAN4;POLR2L -0.48 -6.9 -0.36 2.63e-11 Mean platelet volume; CRC trans rs10982213 0.830 rs2274163 chr9:117188714 C/T cg20284698 chr3:48956327 C3orf71;ARIH2 0.36 6.4 0.33 5.35e-10 Interleukin-6 levels; CRC cis rs765787 0.530 rs4775834 chr15:45537511 C/T cg24006582 chr15:45444508 DUOX1 -0.57 -8.63 -0.43 2.62e-16 Uric acid levels; CRC cis rs6951245 1.000 rs78896566 chr7:1080182 C/G cg21664854 chr7:1097933 C7orf50;GPR146 0.79 8.94 0.44 2.89e-17 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs800160 0.777 rs2651781 chr11:2345677 G/A cg09785033 chr11:2336066 TSPAN32 -0.48 -5.72 -0.3 2.45e-8 Bacteremia; CRC cis rs4332037 0.707 rs56070303 chr7:1891015 C/T cg13880726 chr7:1868755 MAD1L1 -0.42 -5.66 -0.3 3.31e-8 Bipolar disorder; CRC cis rs6502050 0.736 rs11658040 chr17:80059891 C/T cg13198984 chr17:80129470 CCDC57 -0.4 -6.6 -0.34 1.66e-10 Life satisfaction; CRC cis rs2721195 1.000 rs6599530 chr8:145677418 C/G cg15320075 chr8:145703422 NA -0.65 -10.9 -0.52 7.75e-24 Age at first birth; CRC trans rs800082 0.698 rs1178943 chr3:144391772 T/G cg24215973 chr2:240111563 HDAC4 -0.77 -10.32 -0.49 8.16e-22 Smoking behavior; CRC cis rs6546550 0.835 rs3755389 chr2:70119469 T/C cg02498382 chr2:70120550 SNRNP27 -0.54 -9.16 -0.45 5.84e-18 Prevalent atrial fibrillation; CRC cis rs3784262 0.757 rs74655564 chr15:58325512 G/C cg12031962 chr15:58353849 ALDH1A2 -0.36 -6.12 -0.32 2.7e-9 Barrett's esophagus;Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined); CRC cis rs4629180 1.000 rs4851457 chr2:102091220 C/T cg01388757 chr2:102091195 RFX8 0.67 9.17 0.45 5.37e-18 Chronic rhinosinusitis with nasal polyps; CRC cis rs3820928 0.605 rs6718767 chr2:227800776 A/G cg11843606 chr2:227700838 RHBDD1 -0.46 -7.1 -0.36 7.76e-12 Pulmonary function; CRC trans rs8002861 0.664 rs9533662 chr13:44435988 T/A cg17145862 chr1:211918768 LPGAT1 0.57 9.93 0.48 1.73e-20 Leprosy; CRC cis rs5758659 0.904 rs134877 chr22:42662371 C/T cg15557168 chr22:42548783 NA -0.34 -5.69 -0.3 2.83e-8 Cognitive function; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg22703791 chr19:1479558 C19orf25 -0.47 -7.14 -0.37 5.85e-12 Myopia (pathological); CRC cis rs910316 1.000 rs7156105 chr14:75541954 C/A cg03030879 chr14:75389066 RPS6KL1 -0.45 -7.0 -0.36 1.46e-11 Height; CRC cis rs4927850 0.501 rs9881504 chr3:195656614 A/G cg01181863 chr3:195395398 SDHAP2 -0.6 -7.93 -0.4 3.53e-14 Pancreatic cancer; CRC cis rs10504229 0.679 rs111843870 chr8:58126798 A/G cg02725872 chr8:58115012 NA -0.64 -11.55 -0.54 3.85e-26 Developmental language disorder (linguistic errors); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg14787946 chr3:138313112 CEP70 0.41 6.45 0.34 3.9e-10 Intelligence (multi-trait analysis); CRC cis rs4665809 0.941 rs6735145 chr2:26270302 T/C cg26119090 chr2:26468346 HADHA;HADHB -0.61 -7.92 -0.4 3.72e-14 Gut microbiome composition (summer); CRC cis rs4713118 0.715 rs200480 chr6:27773664 A/G cg15845792 chr6:28175446 NA 0.53 7.18 0.37 4.65e-12 Parkinson's disease; CRC cis rs2836974 0.602 rs2836987 chr21:40706594 C/T cg17971929 chr21:40555470 PSMG1 -0.62 -8.76 -0.44 1.01e-16 Cognitive function; CRC cis rs11122272 0.735 rs1416916 chr1:231533027 A/G cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.58 -8.61 -0.43 2.98e-16 Hemoglobin concentration; CRC trans rs9747201 1.000 rs57405744 chr17:80177465 A/G cg07393940 chr7:158741817 NA 0.5 7.05 0.36 1.05e-11 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs7412746 0.658 rs72704652 chr1:150819470 A/G cg17724175 chr1:150552817 MCL1 0.49 7.28 0.37 2.43e-12 Melanoma; CRC cis rs7772486 0.811 rs2777475 chr6:146304603 G/A cg23711669 chr6:146136114 FBXO30 0.59 9.57 0.47 2.76e-19 Lobe attachment (rater-scored or self-reported); CRC cis rs4481887 0.800 rs10788780 chr1:248483598 G/A cg13385794 chr1:248469461 NA 0.4 7.05 0.36 1.04e-11 Common traits (Other); CRC cis rs17270561 0.583 rs7749149 chr6:25781139 G/A cg16482183 chr6:26056742 HIST1H1C 0.69 8.91 0.44 3.65e-17 Iron status biomarkers; CRC cis rs911555 0.655 rs10149470 chr14:104017953 A/G cg24130564 chr14:104152367 KLC1 -0.55 -8.42 -0.42 1.14e-15 Intelligence (multi-trait analysis); CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg07760851 chr11:695000 TMEM80;DEAF1 0.46 5.96 0.31 6.32e-9 Anxiety disorder; CRC cis rs13118159 0.550 rs4974617 chr4:1373658 T/C cg02475777 chr4:1388615 CRIPAK 0.53 6.86 0.35 3.41e-11 Longevity; CRC cis rs2762353 0.595 rs10498728 chr6:25751320 A/T cg03264133 chr6:25882463 NA -0.75 -10.64 -0.51 6.61e-23 Blood metabolite levels; CRC cis rs6543140 0.964 rs6761350 chr2:103030776 A/G cg03938978 chr2:103052716 IL18RAP 0.46 7.22 0.37 3.7e-12 Blood protein levels; CRC cis rs847577 0.609 rs17435847 chr7:97792820 G/A cg21770322 chr7:97807741 LMTK2 0.87 19.64 0.73 2.33e-57 Breast cancer; CRC cis rs10504229 1.000 rs56255635 chr8:58178264 T/C cg22535103 chr8:58192502 C8orf71 -0.82 -12.27 -0.56 9.63e-29 Developmental language disorder (linguistic errors); CRC cis rs9322193 0.923 rs9505823 chr6:149950035 A/C cg00933542 chr6:150070202 PCMT1 0.3 6.1 0.32 2.98e-9 Lung cancer; CRC cis rs4680 1.000 rs4680 chr22:19951271 C/T cg01335087 chr22:19950166 COMT 0.23 6.68 0.35 1.01e-10 Blood metabolite levels; CRC cis rs4409675 0.576 rs10751724 chr1:28215631 C/T cg11176159 chr1:28213800 NA 0.3 5.77 0.3 1.79e-8 Corneal astigmatism; CRC cis rs2120019 1.000 rs12903201 chr15:75370776 A/C cg11632617 chr15:75315747 PPCDC -0.56 -7.96 -0.4 2.86e-14 Blood trace element (Zn levels); CRC cis rs17711722 0.522 rs62469933 chr7:65265639 G/A cg07294406 chr7:64700536 NA 0.35 5.67 0.3 3.1e-8 Calcium levels; CRC cis rs9322193 0.962 rs4870048 chr6:150155460 A/G cg13206674 chr6:150067644 NUP43 0.55 7.77 0.39 1.02e-13 Lung cancer; CRC cis rs6831352 0.959 rs1139490 chr4:100045141 C/T cg13256891 chr4:100009986 ADH5 0.57 8.32 0.42 2.4e-15 Alcohol dependence; CRC cis rs35306767 0.807 rs61831436 chr10:837882 G/A cg26597838 chr10:835615 NA 1.27 14.96 0.64 5.61e-39 Eosinophil percentage of granulocytes; CRC cis rs13118159 0.556 rs4974615 chr4:1373551 A/G cg20887711 chr4:1340912 KIAA1530 -0.65 -9.49 -0.46 4.7e-19 Longevity; CRC cis rs10256972 0.567 rs7782651 chr7:1159895 T/G cg22907277 chr7:1156413 C7orf50 0.71 10.85 0.51 1.17e-23 Longevity;Endometriosis; CRC cis rs3768617 0.811 rs12563494 chr1:183039698 G/A ch.1.3577855R chr1:183094577 LAMC1 0.64 9.41 0.46 8.79e-19 Fuchs's corneal dystrophy; CRC cis rs7635838 0.523 rs9873503 chr3:11396100 T/C cg00170343 chr3:11313890 ATG7 0.44 6.68 0.35 1.05e-10 HDL cholesterol; CRC cis rs8078723 1.000 rs8070454 chr17:38160754 C/T cg17344932 chr17:38183730 MED24;SNORD124 -0.45 -6.9 -0.36 2.73e-11 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); CRC cis rs1799949 0.773 rs2137990 chr17:41317896 T/A cg05368731 chr17:41323189 NBR1 -0.62 -9.32 -0.46 1.77e-18 Menopause (age at onset); CRC cis rs1448094 0.534 rs974818 chr12:86144307 T/C cg00310523 chr12:86230176 RASSF9 -0.36 -5.95 -0.31 6.79e-9 Major depressive disorder; CRC cis rs10504229 0.728 rs17215621 chr8:58152706 C/A cg11062466 chr8:58055876 NA 0.45 6.11 0.32 2.74e-9 Developmental language disorder (linguistic errors); CRC trans rs11225569 0.539 rs72987442 chr11:103314023 A/G cg01615333 chr12:127765195 NA -0.63 -5.97 -0.31 6.2e-9 Diisocyanate-induced asthma; CRC cis rs12477438 0.501 rs34272114 chr2:99737443 A/C cg26064155 chr2:99771622 LIPT1;TSGA10 0.77 13.12 0.59 6.33e-32 Chronic sinus infection; CRC cis rs9427116 0.502 rs903323 chr1:154572228 A/G cg24304309 chr1:154577895 ADAR -0.34 -5.74 -0.3 2.18e-8 Blood protein levels; CRC cis rs4074961 0.692 rs11264075 chr1:38083941 C/G cg13401533 chr1:37979913 MEAF6 0.4 5.7 0.3 2.71e-8 Axial length; CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg17322444 chr19:33572249 GPATCH1 -0.51 -6.28 -0.33 1.05e-9 Diisocyanate-induced asthma; CRC cis rs875971 1.000 rs778685 chr7:65836176 G/T cg11764359 chr7:65958608 NA 0.61 9.95 0.48 1.41e-20 Aortic root size; CRC cis rs727505 0.754 rs55905546 chr7:124783064 A/C cg23710748 chr7:124431027 NA -0.67 -11.43 -0.53 1.04e-25 Lewy body disease; CRC cis rs6502050 0.799 rs34795957 chr17:80118013 G/A cg22110888 chr17:80059540 CCDC57 0.4 6.45 0.34 3.95e-10 Life satisfaction; CRC cis rs2404602 1.000 rs12443137 chr15:76840832 G/T cg03037974 chr15:76606532 NA 0.57 9.52 0.46 3.82e-19 Blood metabolite levels; CRC cis rs62064224 0.589 rs2285428 chr17:30820176 C/T cg09324608 chr17:30823087 MYO1D -0.35 -5.95 -0.31 6.72e-9 Schizophrenia; CRC cis rs3087591 1.000 rs8068801 chr17:29570587 G/T cg24425628 chr17:29625626 OMG;NF1 -0.84 -16.19 -0.67 8.76e-44 Hip circumference; CRC cis rs12701220 0.500 rs6463224 chr7:1140418 C/A cg04498913 chr7:1135747 C7orf50 -0.5 -6.29 -0.33 9.95e-10 Bronchopulmonary dysplasia; CRC cis rs3749237 0.595 rs4855873 chr3:49459114 A/C cg03060546 chr3:49711283 APEH 0.61 10.39 0.5 4.7e-22 Resting heart rate; CRC cis rs780096 0.526 rs75855890 chr2:27625005 G/T cg27432699 chr2:27873401 GPN1 -0.61 -9.26 -0.45 2.74e-18 Total body bone mineral density; CRC cis rs6456156 0.774 rs6930998 chr6:167526940 A/C cg07513332 chr6:167530253 CCR6 -0.45 -8.24 -0.41 4.23e-15 Primary biliary cholangitis; CRC cis rs4819052 0.851 rs2838864 chr21:46711474 A/T cg19498844 chr21:46707878 POFUT2;LOC642852 -0.72 -10.6 -0.5 8.84e-23 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs10992471 0.603 rs12342019 chr9:95192508 C/T cg14631576 chr9:95140430 CENPP -0.41 -7.24 -0.37 3.14e-12 Visceral adipose tissue/subcutaneous adipose tissue ratio; CRC trans rs11148252 0.624 rs6561682 chr13:53266297 A/G cg18335740 chr13:41363409 SLC25A15 -0.52 -7.39 -0.38 1.19e-12 Lewy body disease; CRC trans rs783540 0.774 rs28415133 chr15:83264713 G/C cg18393722 chr15:85113863 UBE2QP1 -0.35 -6.1 -0.32 2.94e-9 Schizophrenia; CRC cis rs1348850 0.560 rs13019660 chr2:178498214 C/T cg22681709 chr2:178499509 PDE11A -0.34 -5.69 -0.3 2.86e-8 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg02987984 chr7:101457447 NA 0.44 6.12 0.32 2.6e-9 Response to antipsychotic treatment; CRC cis rs9381040 0.655 rs7738684 chr6:41038552 G/A cg25110423 chr6:41068646 NFYA;LOC221442 -0.4 -6.04 -0.32 4.23e-9 Alzheimer's disease (late onset); CRC cis rs1697139 0.583 rs17289614 chr5:66541592 G/A cg11553311 chr5:66541588 NA 0.57 9.78 0.47 5.32e-20 Breast cancer; CRC cis rs2282802 0.685 rs6580473 chr5:139646962 C/T cg26211634 chr5:139558579 C5orf32 -0.37 -6.11 -0.32 2.78e-9 Intelligence (multi-trait analysis); CRC cis rs12701220 0.947 rs1007765 chr7:1032805 G/C cg02733842 chr7:1102375 C7orf50 -0.74 -8.64 -0.43 2.5e-16 Bronchopulmonary dysplasia; CRC cis rs853679 0.517 rs9393901 chr6:28136797 A/G cg12963246 chr6:28129442 ZNF389 0.49 5.7 0.3 2.71e-8 Depression; CRC cis rs832540 0.898 rs170732 chr5:56251777 C/T cg24531977 chr5:56204891 C5orf35 -0.46 -7.37 -0.38 1.4e-12 Coronary artery disease; CRC cis rs9303280 0.806 rs9909593 chr17:37970149 C/T cg20243544 chr17:37824526 PNMT -0.37 -5.7 -0.3 2.72e-8 Self-reported allergy; CRC cis rs853679 0.517 rs9380060 chr6:28132603 G/A cg02683197 chr6:28174875 NA 0.87 10.73 0.51 3.25e-23 Depression; CRC trans rs75804782 0.641 rs11885523 chr2:239344263 G/A cg01134436 chr17:81009848 B3GNTL1 0.74 6.97 0.36 1.7e-11 Morning vs. evening chronotype;Chronotype; CRC cis rs294883 0.858 rs2340803 chr6:159712800 A/G cg14500486 chr6:159655392 FNDC1 -0.35 -5.75 -0.3 2.09e-8 Coronary artery disease; CRC cis rs12908161 0.959 rs34342559 chr15:85331271 A/G cg17507749 chr15:85114479 UBE2QP1 0.63 8.87 0.44 4.74e-17 Schizophrenia; CRC cis rs4604732 0.631 rs10925044 chr1:247627071 A/G cg12754571 chr1:247694271 LOC148824;OR2C3 0.41 5.78 0.3 1.74e-8 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CRC trans rs7395662 0.864 rs7482764 chr11:48625858 T/A cg21153622 chr11:89784906 NA -0.47 -7.55 -0.38 4.44e-13 HDL cholesterol; CRC cis rs3806843 0.735 rs801180 chr5:140092903 G/T cg19875535 chr5:140030758 IK -0.63 -10.52 -0.5 1.71e-22 Depressive symptoms (multi-trait analysis); CRC cis rs6963495 0.818 rs56177071 chr7:105165648 C/T cg02135003 chr7:105160482 PUS7 -0.91 -12.41 -0.56 2.87e-29 Bipolar disorder (body mass index interaction); CRC cis rs2976388 0.647 rs2585154 chr8:143783485 C/T cg24046110 chr8:143859143 LYNX1 0.45 7.7 0.39 1.61e-13 Urinary tract infection frequency; CRC cis rs4713118 0.513 rs149958 chr6:28013617 A/C cg23161317 chr6:28129485 ZNF389 0.45 6.32 0.33 8.63e-10 Parkinson's disease; CRC cis rs10504229 0.639 rs66667899 chr8:58117065 C/T cg24829409 chr8:58192753 C8orf71 -0.55 -8.03 -0.4 1.71e-14 Developmental language disorder (linguistic errors); CRC cis rs992157 0.710 rs13026485 chr2:219057984 C/T cg04731861 chr2:219085781 ARPC2 0.31 6.47 0.34 3.57e-10 Colorectal cancer; CRC cis rs4713118 0.614 rs9380007 chr6:27660508 T/C cg12273811 chr6:28175739 NA 0.4 5.91 0.31 8.72e-9 Parkinson's disease; CRC cis rs2635047 0.967 rs3816125 chr18:44601611 C/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 -0.46 -7.15 -0.37 5.56e-12 Educational attainment; CRC cis rs909674 0.524 rs5757670 chr22:39829736 G/A cg11247378 chr22:39784982 NA -0.47 -9.32 -0.46 1.73e-18 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg22960635 chr16:1543151 TELO2 0.45 6.33 0.33 7.96e-10 Response to antipsychotic treatment; CRC cis rs9292777 0.748 rs10512736 chr5:40395386 T/A cg09067459 chr5:40385259 NA -0.56 -9.27 -0.45 2.57e-18 Crohn's disease;Multiple sclerosis; CRC cis rs17001868 0.568 rs909669 chr22:40742417 C/T cg07138101 chr22:40742427 ADSL 0.6 8.0 0.4 2.16e-14 Mammographic density (dense area); CRC cis rs734999 0.545 rs4074789 chr1:2537464 A/G cg18854424 chr1:2615690 NA 0.49 9.81 0.48 4.4e-20 Ulcerative colitis; CRC cis rs561341 1.000 rs113115092 chr17:30284164 G/A cg19193384 chr17:30244184 NA -0.65 -7.48 -0.38 6.75e-13 Hip circumference adjusted for BMI; CRC trans rs6076960 0.684 rs6054059 chr20:6262472 G/T cg24759859 chr6:86352639 SYNCRIP 0.48 6.59 0.34 1.74e-10 Smooth-surface caries; CRC cis rs5753618 0.561 rs714909 chr22:31741067 G/A cg22777020 chr22:31556080 RNF185 0.55 6.29 0.33 1.01e-9 Colorectal cancer; CRC cis rs2204008 0.640 rs11520199 chr12:38211026 T/C cg13010199 chr12:38710504 ALG10B 0.45 5.74 0.3 2.1e-8 Bladder cancer; CRC cis rs875971 0.862 rs2024192 chr7:66041447 G/T cg00343986 chr7:65444356 GUSB -0.44 -6.17 -0.32 2.02e-9 Aortic root size; CRC cis rs12580194 0.593 rs12296692 chr12:55756851 A/G cg19537932 chr12:55886519 OR6C68 -0.67 -8.84 -0.44 6.06e-17 Cancer; CRC trans rs11654801 0.812 rs11204327 chr17:20862566 C/T cg23759823 chr7:139672531 TBXAS1 -0.42 -6.24 -0.33 1.37e-9 Mosquito bite size; CRC cis rs873946 0.586 rs2001426 chr10:134563871 G/A cg06453172 chr10:134556979 INPP5A -0.68 -8.14 -0.41 8.53e-15 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CRC cis rs9896933 0.732 rs590886 chr17:80767350 A/G cg20578329 chr17:80767326 TBCD 0.81 10.71 0.51 3.7e-23 Bone mineral accretion in asthma (oral corticosteroid dose interaction); CRC cis rs7827545 1.000 rs7832857 chr8:135565477 A/G cg13086574 chr8:135490821 ZFAT -0.36 -6.08 -0.32 3.34e-9 Hypertension (SNP x SNP interaction); CRC cis rs9926296 0.528 rs4785721 chr16:89839997 G/A cg04287289 chr16:89883240 FANCA 0.84 15.23 0.64 5.11e-40 Vitiligo; CRC cis rs4589502 0.502 rs2169460 chr15:67197240 A/G cg12317470 chr15:67143691 NA -0.71 -10.35 -0.5 6.34e-22 Lung cancer (smoking interaction); CRC cis rs889398 0.741 rs2362642 chr16:69931458 G/A cg00738113 chr16:70207722 CLEC18C -0.4 -6.63 -0.34 1.38e-10 Body mass index; CRC cis rs7591163 0.883 rs11891398 chr2:228723357 C/T cg14329157 chr2:228736135 WDR69 -0.44 -6.1 -0.32 3e-9 Blood pressure; CRC cis rs3849570 1.000 rs3772883 chr3:81802802 C/T cg07356753 chr3:81810745 GBE1 -0.6 -8.49 -0.42 7.44e-16 Waist circumference;Body mass index; CRC cis rs875971 0.660 rs10263935 chr7:66096028 A/G cg11764359 chr7:65958608 NA 0.51 7.86 0.4 5.66e-14 Aortic root size; CRC cis rs10971721 0.822 rs72727335 chr9:33931718 C/T cg13495928 chr9:33750294 PRSS3 0.56 5.95 0.31 6.96e-9 Body mass index; CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg24847481 chr1:100435557 SLC35A3 0.39 6.71 0.35 8.55e-11 Obesity-related traits; CRC cis rs524281 0.861 rs10791855 chr11:65963737 A/G cg14036092 chr11:66035641 RAB1B -0.47 -5.67 -0.3 3.1e-8 Electroencephalogram traits; CRC trans rs2303319 0.504 rs56145818 chr2:162403778 G/A cg18122310 chr12:50236657 BCDIN3D -0.72 -6.04 -0.32 4.15e-9 Cognitive function; CRC cis rs9322193 0.923 rs12174716 chr6:149965623 C/T cg13206674 chr6:150067644 NUP43 0.64 9.58 0.47 2.41e-19 Lung cancer; CRC cis rs8062405 0.737 rs11861132 chr16:28871860 A/G cg08761264 chr16:28874980 SH2B1 -0.44 -5.77 -0.3 1.84e-8 Cognitive ability (multi-trait analysis);Cognitive ability; CRC cis rs801193 0.569 rs10950050 chr7:66239588 A/C cg18876405 chr7:65276391 NA 0.5 8.34 0.42 2.11e-15 Aortic root size; CRC cis rs875971 1.000 rs6956179 chr7:65806659 C/T cg18912574 chr7:65842487 NCRNA00174 -0.34 -5.86 -0.31 1.1e-8 Aortic root size; CRC cis rs6938 0.514 rs35556055 chr15:75253414 G/A cg14664628 chr15:75095509 CSK -0.53 -7.61 -0.39 2.93e-13 Breast cancer; CRC cis rs644799 0.710 rs56384142 chr11:95502075 G/T cg25478527 chr11:95522999 CEP57;FAM76B 0.49 7.49 0.38 6.2800000000000005e-13 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs6500602 0.627 rs4786494 chr16:4506232 G/A cg14951292 chr16:4525986 HMOX2;NMRAL1 0.63 8.78 0.44 8.81e-17 Schizophrenia; CRC cis rs2836950 0.527 rs2836958 chr21:40623526 T/C cg06238570 chr21:40685208 BRWD1 -0.64 -9.25 -0.45 2.93e-18 Menarche (age at onset); CRC cis rs546131 0.928 rs572690 chr11:34833614 A/G cg24088639 chr11:34937564 PDHX;APIP -0.47 -6.49 -0.34 3.22e-10 Lung disease severity in cystic fibrosis; CRC cis rs6582630 0.537 rs35336822 chr12:38346251 T/C cg26384229 chr12:38710491 ALG10B 0.68 9.68 0.47 1.12e-19 Drug-induced liver injury (flucloxacillin); CRC cis rs62244186 0.545 rs7640654 chr3:44763037 A/C cg15687855 chr3:44754131 ZNF502 -0.34 -5.8 -0.3 1.59e-8 Depressive symptoms; CRC cis rs7927771 0.524 rs1056387 chr11:47681370 A/C cg20307385 chr11:47447363 PSMC3 0.43 6.12 0.32 2.7e-9 Subjective well-being; CRC cis rs7725052 0.609 rs4498294 chr5:40453522 T/C cg09067459 chr5:40385259 NA -0.4 -6.68 -0.35 9.91e-11 Pediatric autoimmune diseases; CRC cis rs728616 0.867 rs56198874 chr10:81686488 C/T cg05935833 chr10:81318306 SFTPA2 -0.72 -8.18 -0.41 6.47e-15 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs2549003 1.000 rs2070723 chr5:131823187 A/G cg02551604 chr5:131831745 NA -0.55 -8.49 -0.42 7.35e-16 Asthma (sex interaction); CRC cis rs875971 0.638 rs10278816 chr7:66036987 T/C cg00343986 chr7:65444356 GUSB -0.5 -7.43 -0.38 9.64e-13 Aortic root size; CRC cis rs1862618 0.853 rs43184 chr5:56141777 G/C cg12311346 chr5:56204834 C5orf35 -0.79 -10.4 -0.5 4.19e-22 Initial pursuit acceleration; CRC cis rs875971 1.000 rs7789554 chr7:65946038 A/G cg11764359 chr7:65958608 NA 0.63 10.13 0.49 3.71e-21 Aortic root size; CRC cis rs9847710 1.000 rs13088455 chr3:53087482 C/G cg04503182 chr3:53078218 SFMBT1 -0.45 -7.18 -0.37 4.53e-12 Ulcerative colitis; CRC cis rs9487051 0.714 rs13209277 chr6:109624963 T/A cg12927641 chr6:109611667 NA -0.35 -6.23 -0.32 1.4e-9 Reticulocyte fraction of red cells; CRC trans rs10506458 0.915 rs12426308 chr12:63405778 C/T cg22491629 chr6:157744540 C6orf35 -0.76 -9.17 -0.45 5.2e-18 Hemostatic factors and hematological phenotypes; CRC cis rs7119 0.717 rs8032071 chr15:77745762 C/T cg05673287 chr15:77411982 SGK269 0.56 8.23 0.41 4.45e-15 Type 2 diabetes; CRC cis rs9303280 0.806 rs10445308 chr17:37938047 C/T cg11212589 chr17:38028394 ZPBP2 0.36 6.71 0.35 8.34e-11 Self-reported allergy; CRC cis rs9811920 0.638 rs793471 chr3:99546335 A/C cg07805332 chr3:99536008 MIR548G;C3orf26 0.51 7.61 0.39 2.9e-13 Axial length; CRC cis rs3617 0.625 rs7617468 chr3:52849549 T/C cg11645453 chr3:52864694 ITIH4 0.46 9.18 0.45 4.9e-18 Red blood cell count;Autism spectrum disorder or schizophrenia; CRC cis rs6951245 1.000 rs75016635 chr7:1094121 G/A cg22907277 chr7:1156413 C7orf50 0.73 7.7 0.39 1.59e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs3540 0.553 rs2158406 chr15:90994499 T/C cg22089800 chr15:90895588 ZNF774 0.58 9.56 0.47 2.84e-19 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; CRC cis rs3816788 0.620 rs11783414 chr8:21773384 A/G cg17168535 chr8:21777572 XPO7 -0.56 -9.04 -0.45 1.37e-17 Lung cancer in ever smokers; CRC cis rs6831352 0.918 rs4699714 chr4:100060538 A/G cg12011299 chr4:100065546 ADH4 -0.5 -9.49 -0.46 5.01e-19 Alcohol dependence; CRC cis rs752092 1.000 rs752092 chr15:101781934 C/T cg19997662 chr15:101784653 CHSY1 0.63 10.32 0.49 7.86e-22 Corneal structure; CRC cis rs2760061 0.626 rs591582 chr1:228117360 C/A cg02753203 chr1:228287806 NA -0.65 -9.74 -0.47 7.28e-20 Diastolic blood pressure; CRC cis rs155076 1.000 rs564685 chr13:21846879 A/G cg25811766 chr13:21894605 NA -0.57 -6.0 -0.31 5.12e-9 White matter hyperintensity burden; CRC cis rs12142240 0.698 rs1053628 chr1:46827769 C/T cg14993813 chr1:46806288 NSUN4 -0.49 -6.26 -0.33 1.17e-9 Menopause (age at onset); CRC cis rs473651 0.692 rs579511 chr2:239334914 C/G cg08773314 chr2:239334832 ASB1 0.38 8.7 0.43 1.67e-16 Multiple system atrophy; CRC cis rs853679 0.517 rs9393893 chr6:28109262 T/C cg23161317 chr6:28129485 ZNF389 0.53 6.43 0.33 4.52e-10 Depression; CRC cis rs60843830 1.000 rs62114501 chr2:231741 C/T cg00108164 chr2:264199 ACP1;SH3YL1 0.64 10.12 0.49 3.89e-21 Spherical equivalent (joint analysis main effects and education interaction); CRC cis rs4713118 0.540 rs469227 chr6:27970705 A/C cg23161317 chr6:28129485 ZNF389 0.47 6.64 0.34 1.28e-10 Parkinson's disease; CRC cis rs826838 0.616 rs7977357 chr12:38626008 C/G cg26384229 chr12:38710491 ALG10B -0.52 -7.52 -0.38 5.28e-13 Heart rate; CRC cis rs71403859 0.730 rs17347255 chr16:71587225 C/T cg08717414 chr16:71523259 ZNF19 -0.96 -9.32 -0.46 1.78e-18 Post bronchodilator FEV1; CRC cis rs71403859 0.803 rs34381861 chr16:71640230 T/C cg08717414 chr16:71523259 ZNF19 -1.14 -10.91 -0.52 7.62e-24 Post bronchodilator FEV1; CRC cis rs6543140 0.964 rs13390895 chr2:103075499 G/A cg04239558 chr2:103089729 SLC9A4 0.37 6.58 0.34 1.83e-10 Blood protein levels; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg24718819 chr3:194033680 NA 0.38 6.19 0.32 1.83e-9 Liver disease severity in Alagille syndrome; CRC cis rs34375054 0.624 rs7295689 chr12:125680922 T/G cg06287003 chr12:125626642 AACS -0.59 -7.68 -0.39 1.81e-13 Post bronchodilator FEV1/FVC ratio; CRC cis rs6121246 0.580 rs6121016 chr20:30245239 C/T cg18721089 chr20:30220636 NA -0.37 -5.85 -0.31 1.2e-8 Mean corpuscular hemoglobin; CRC cis rs7618915 0.547 rs2289250 chr3:52682946 A/C cg05573699 chr3:52720067 GNL3;PBRM1 0.49 6.99 0.36 1.54e-11 Bipolar disorder; CRC cis rs7909074 1.000 rs10900128 chr10:45393201 G/T cg04218760 chr10:45406644 TMEM72 -0.34 -9.69 -0.47 1.08e-19 Mean corpuscular volume; CRC trans rs34421088 0.560 rs2248325 chr8:11396874 A/G cg16141378 chr3:129829833 LOC729375 0.46 6.83 0.35 4.18e-11 Neuroticism; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg25580254 chr12:8088937 SLC2A3 -0.58 -9.33 -0.46 1.64e-18 Liver disease severity in Alagille syndrome; CRC cis rs12543725 0.601 rs7018178 chr8:142239210 C/T cg03316587 chr8:142245164 NA 0.43 6.8 0.35 4.91e-11 Birth weight; CRC cis rs1707322 0.721 rs12091503 chr1:46107868 T/C cg03146154 chr1:46216737 IPP 0.67 9.85 0.48 3.2e-20 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs7408868 1.000 rs7247906 chr19:15271135 T/G cg14696996 chr19:15285081 NOTCH3 0.97 8.99 0.44 1.99e-17 Pulse pressure; CRC cis rs78456975 0.739 rs72776248 chr2:1521314 A/G cg26248373 chr2:1572462 NA -0.63 -7.15 -0.37 5.54e-12 Placebo response in major depressive disorder (% change in symptom score); CRC trans rs11039798 0.588 rs10437592 chr11:48598859 G/T cg03929089 chr4:120376271 NA 0.67 7.22 0.37 3.61e-12 Axial length; CRC cis rs8170 0.859 rs11540855 chr19:17403361 A/G cg04749549 chr19:17459798 NA -0.46 -6.06 -0.32 3.74e-9 Breast cancer (estrogen-receptor negative);Breast Cancer in BRCA1 mutation carriers;Ovarian cancer;Breast cancer;Epithelial ovarian cancer; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg19628164 chr3:143689916 C3orf58 0.4 6.37 0.33 6.35e-10 Liver disease severity in Alagille syndrome; CRC cis rs798766 1.000 rs798767 chr4:1734281 A/G cg05874882 chr4:1763078 NA -0.38 -6.94 -0.36 2.15e-11 Bladder cancer;Urinary bladder cancer; CRC cis rs9467711 0.606 rs16891727 chr6:26488860 C/A cg16898833 chr6:26189333 HIST1H4D 0.84 6.93 0.36 2.27e-11 Autism spectrum disorder or schizophrenia; CRC cis rs35264875 1.000 rs1542334 chr11:68850773 G/C cg03469862 chr11:68924853 NA 0.46 5.91 0.31 8.56e-9 Blond vs. brown hair color; CRC cis rs2576037 0.523 rs4890705 chr18:44509758 A/G cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.63 10.52 0.5 1.61e-22 Personality dimensions; CRC cis rs10504229 0.683 rs2318143 chr8:58114660 C/T cg21724239 chr8:58056113 NA 0.49 6.77 0.35 5.94e-11 Developmental language disorder (linguistic errors); CRC cis rs1559088 0.947 rs7256182 chr19:33558591 G/A cg27124370 chr19:33622961 WDR88 0.41 5.65 0.3 3.46e-8 Bone ultrasound measurement (broadband ultrasound attenuation); CRC cis rs2576037 0.523 rs1539881 chr18:44477897 C/T cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.57 -8.79 -0.44 8.4e-17 Personality dimensions; CRC cis rs12220238 1.000 rs7096553 chr10:75957835 A/G cg19889307 chr10:75911429 ADK;AP3M1 0.55 5.7 0.3 2.62e-8 Soluble interleukin-2 receptor subunit alpha; CRC cis rs7811142 0.830 rs41280971 chr7:99954457 G/T cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.62 8.0 0.4 2.19e-14 Platelet count; CRC cis rs853679 0.517 rs9468292 chr6:28095355 G/A cg03623178 chr6:28175578 NA 0.96 12.57 0.57 7.23e-30 Depression; CRC cis rs4665809 0.887 rs28699126 chr2:26357294 C/T cg22920501 chr2:26401640 FAM59B -0.54 -7.6 -0.39 3.1e-13 Gut microbiome composition (summer); CRC cis rs4638749 0.677 rs998186 chr2:108844237 C/T cg25838818 chr2:108905173 SULT1C2 -0.33 -5.61 -0.3 4.35e-8 Blood pressure; CRC cis rs2440129 0.632 rs2292353 chr17:6903537 C/T cg08946332 chr17:6899888 ALOX12 0.34 5.78 0.3 1.76e-8 Tonsillectomy; CRC cis rs8180040 0.966 rs6792461 chr3:47473168 C/T cg02527881 chr3:46936655 PTH1R 0.38 6.9 0.36 2.65e-11 Colorectal cancer; CRC cis rs2712184 0.687 rs62180470 chr2:217645451 A/G cg05032264 chr2:217675019 NA 0.33 5.8 0.3 1.56e-8 Glomerular filtration rate;Glomerular filtration rate in non diabetics (creatinine); CRC cis rs910316 0.789 rs12894419 chr14:75471802 C/T cg03030879 chr14:75389066 RPS6KL1 -0.42 -6.43 -0.33 4.62e-10 Height; CRC cis rs2952156 0.684 rs881844 chr17:37810218 C/G cg15445000 chr17:37608096 MED1 0.27 5.95 0.31 6.8e-9 Asthma; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg25113610 chr2:74007324 DUSP11 0.44 6.09 0.32 3.13e-9 Response to antipsychotic treatment; CRC cis rs4819052 0.851 rs4819038 chr21:46659393 C/T cg02159808 chr21:46707872 POFUT2;LOC642852 0.49 6.41 0.33 5.19e-10 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs2933343 0.951 rs789218 chr3:128592670 G/A cg11901034 chr3:128598214 ACAD9 -0.53 -6.34 -0.33 7.46e-10 IgG glycosylation; CRC cis rs7666738 0.830 rs7696715 chr4:98938486 T/C cg17366294 chr4:99064904 C4orf37 0.43 7.32 0.37 1.95e-12 Colonoscopy-negative controls vs population controls; CRC trans rs11039798 0.588 rs12284168 chr11:48555627 C/T cg15704280 chr7:45808275 SEPT13 0.66 6.74 0.35 7.01e-11 Axial length; CRC cis rs4665809 1.000 rs6546768 chr2:26328800 A/G cg04944784 chr2:26401820 FAM59B -0.6 -7.57 -0.39 3.84e-13 Gut microbiome composition (summer); CRC cis rs7811142 1.000 rs66632384 chr7:100018904 G/A cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.15 17.19 0.69 1.08e-47 Platelet count; CRC cis rs4713118 0.868 rs35069907 chr6:27746692 T/C cg15786705 chr6:28176104 NA 0.57 6.36 0.33 6.77e-10 Parkinson's disease; CRC cis rs4713118 0.527 rs35949862 chr6:28115367 A/G cg15786705 chr6:28176104 NA 0.78 9.83 0.48 3.57e-20 Parkinson's disease; CRC cis rs9372498 0.536 rs72952761 chr6:118866758 A/C cg15382696 chr6:118971807 C6orf204 0.61 7.88 0.4 4.86e-14 Diastolic blood pressure; CRC cis rs11229555 1.000 rs11229555 chr11:58408687 G/T cg15696309 chr11:58395628 NA -0.97 -13.73 -0.6 3.12e-34 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; CRC cis rs17376456 0.690 rs6892055 chr5:93113023 A/T cg25358565 chr5:93447407 FAM172A 0.91 8.76 0.43 1.03e-16 Diabetic retinopathy; CRC cis rs10484885 0.878 rs17506550 chr6:90508896 A/G cg13799429 chr6:90582589 CASP8AP2 -0.75 -7.91 -0.4 4.07e-14 QRS interval (sulfonylurea treatment interaction); CRC cis rs801193 0.527 rs2707837 chr7:66181073 G/C cg00343986 chr7:65444356 GUSB 0.45 6.27 0.33 1.12e-9 Aortic root size; CRC cis rs6988985 0.530 rs57268571 chr8:143942602 A/G cg10324643 chr8:143916377 GML 0.36 6.04 0.32 4.18e-9 Plasma androstenedione levels in resected early stage-receptor positive breast cancer; CRC cis rs1799949 1.000 rs2037075 chr17:41305826 G/T cg05368731 chr17:41323189 NBR1 0.64 9.47 0.46 5.45e-19 Menopause (age at onset); CRC trans rs2898290 0.592 rs2736342 chr8:11347289 A/C cg06636001 chr8:8085503 FLJ10661 -0.47 -7.26 -0.37 2.9e-12 Systolic blood pressure; CRC cis rs1656402 1.000 rs6749955 chr2:233437917 A/C cg03852847 chr2:233439513 NA 0.45 7.64 0.39 2.44e-13 Non-small cell lung cancer (survival); CRC cis rs2836950 0.520 rs8133928 chr21:40689963 G/A cg17971929 chr21:40555470 PSMG1 -0.52 -7.38 -0.38 1.34e-12 Menarche (age at onset); CRC cis rs972578 1.000 rs2010366 chr22:43381288 T/G cg01576275 chr22:43409880 NA -0.46 -6.96 -0.36 1.88e-11 Mean platelet volume; CRC cis rs11122272 0.668 rs2472261 chr1:231505701 G/A cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.5 -7.3 -0.37 2.12e-12 Hemoglobin concentration; CRC cis rs2115630 0.967 rs11073702 chr15:85310071 G/A cg09876464 chr15:85330779 ZNF592 0.45 7.66 0.39 2.05e-13 P wave terminal force; CRC cis rs10504229 0.593 rs16921589 chr8:58024387 C/A cg02725872 chr8:58115012 NA -0.44 -6.61 -0.34 1.51e-10 Developmental language disorder (linguistic errors); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg17344085 chr7:100450162 SLC12A9 0.42 6.59 0.34 1.74e-10 Intelligence (multi-trait analysis); CRC cis rs35110281 0.805 rs3788062 chr21:44991159 C/T cg01579765 chr21:45077557 HSF2BP -0.37 -7.17 -0.37 5.07e-12 Mean corpuscular volume; CRC cis rs11971779 0.616 rs6944244 chr7:139051186 T/C cg23387468 chr7:139079360 LUC7L2 0.41 7.04 0.36 1.14e-11 Diisocyanate-induced asthma; CRC cis rs12586317 0.511 rs11540758 chr14:35498485 C/T cg05294307 chr14:35346193 BAZ1A -0.69 -7.47 -0.38 7.35e-13 Psoriasis; CRC cis rs7131987 0.903 rs918873 chr12:29390501 G/T cg09582351 chr12:29534625 ERGIC2 -0.29 -6.28 -0.33 1.09e-9 QT interval; CRC cis rs116095464 0.558 rs7725227 chr5:233517 G/A cg22857025 chr5:266934 NA -1.25 -16.79 -0.68 3.81e-46 Breast cancer; CRC cis rs12477438 0.520 rs7604557 chr2:99747829 A/G cg26064155 chr2:99771622 LIPT1;TSGA10 0.9 16.75 0.68 5.43e-46 Chronic sinus infection; CRC cis rs6460942 0.732 rs73677576 chr7:12286535 G/A cg06484146 chr7:12443880 VWDE -0.63 -6.52 -0.34 2.61e-10 Coronary artery disease; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg01204964 chr21:35014044 ITSN1;CRYZL1 0.39 6.48 0.34 3.45e-10 Liver disease severity in Alagille syndrome; CRC cis rs9611565 0.802 rs9611577 chr22:41793090 T/G cg03806693 chr22:41940476 POLR3H -0.95 -11.98 -0.55 1.13e-27 Vitiligo; CRC cis rs4594175 0.926 rs4131365 chr14:51622444 C/T cg23942311 chr14:51606299 NA 0.64 10.31 0.49 8.54e-22 Cancer; CRC cis rs8177253 0.965 rs4854762 chr3:133499063 A/G cg08048268 chr3:133502702 NA 0.38 7.31 0.37 2e-12 Iron status biomarkers; CRC trans rs7726839 0.540 rs7434 chr5:660804 A/G cg25482853 chr8:67687455 SGK3 -1.11 -13.32 -0.59 1.11e-32 Obesity-related traits; CRC cis rs9399135 0.967 rs6915770 chr6:135369214 G/A cg22676075 chr6:135203613 NA 0.39 6.08 0.32 3.42e-9 Red blood cell count; CRC cis rs7223966 0.960 rs11659013 chr17:61869559 C/G cg05941027 chr17:61774174 LIMD2 0.35 6.31 0.33 8.87e-10 Hip circumference adjusted for BMI;Body mass index; CRC cis rs1552172 0.887 rs4970874 chr1:145709394 T/C cg11743829 chr1:145714124 CD160 -0.41 -6.09 -0.32 3.19e-9 Breast cancer; CRC cis rs3820068 0.705 rs4646096 chr1:15820758 A/G cg27534772 chr1:16042836 PLEKHM2 0.41 6.95 0.36 1.99e-11 Systolic blood pressure; CRC cis rs79839061 0.610 rs73207794 chr4:872020 T/C cg14530993 chr4:882597 GAK 0.79 7.2 0.37 4.22e-12 Intelligence (multi-trait analysis); CRC cis rs4663969 0.873 rs759174 chr2:234668245 A/C cg02227331 chr2:234663937 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 0.35 5.7 0.3 2.64e-8 Total bilirubin levels in HIV-1 infection; CRC cis rs13315871 0.929 rs35376204 chr3:58325563 T/C cg20936604 chr3:58311152 NA -0.76 -7.27 -0.37 2.69e-12 Cholesterol, total; CRC cis rs9322193 0.923 rs12529698 chr6:149972087 G/A cg00933542 chr6:150070202 PCMT1 0.32 6.55 0.34 2.22e-10 Lung cancer; CRC cis rs4474465 1.000 rs10899513 chr11:78172353 T/C cg27205649 chr11:78285834 NARS2 -0.48 -5.94 -0.31 7.15e-9 Alzheimer's disease (survival time); CRC cis rs780096 0.506 rs2950834 chr2:27627366 G/A cg02592271 chr2:27665507 KRTCAP3 -0.27 -6.21 -0.32 1.57e-9 Total body bone mineral density; CRC cis rs10791323 0.569 rs11223609 chr11:133741766 C/T cg06766960 chr11:133703094 NA -0.35 -6.44 -0.33 4.29e-10 Childhood ear infection; CRC cis rs28386778 0.830 rs2854210 chr17:61946338 C/A cg25654072 chr17:61904446 PSMC5;FTSJ3 0.72 11.16 0.52 9.94e-25 Prudent dietary pattern; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg23713156 chr17:80606235 WDR45L 0.42 6.72 0.35 7.93e-11 Liver disease severity in Alagille syndrome; CRC cis rs2380220 0.808 rs2380224 chr6:95895553 C/T cg04719120 chr6:96025338 MANEA -0.53 -5.88 -0.31 9.93e-9 Behavioural disinhibition (generation interaction); CRC cis rs2535633 0.631 rs2710313 chr3:52969529 T/A cg11645453 chr3:52864694 ITIH4 -0.42 -7.78 -0.39 9.3e-14 Body mass index; CRC cis rs9372498 0.536 rs72952793 chr6:118892979 T/A cg01339444 chr6:118972232 C6orf204 0.55 6.14 0.32 2.35e-9 Diastolic blood pressure; CRC cis rs7618501 0.602 rs2624816 chr3:50117312 T/G cg05623727 chr3:50126028 RBM5 -0.44 -7.47 -0.38 7.28e-13 Intelligence (multi-trait analysis); CRC cis rs523522 0.962 rs3759394 chr12:120933173 C/A cg27279351 chr12:120934652 DYNLL1 0.79 11.6 0.54 2.58e-26 High light scatter reticulocyte count; CRC cis rs7264396 0.563 rs6060567 chr20:34288250 G/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.49 -6.97 -0.36 1.7e-11 Total cholesterol levels; CRC cis rs9992667 0.910 rs28681431 chr4:38687928 G/A cg19726192 chr4:38663646 FLJ13197 -0.7 -8.92 -0.44 3.35e-17 Eosinophil percentage of granulocytes; CRC cis rs477692 0.789 rs506915 chr10:131398005 A/G cg05714579 chr10:131428358 MGMT 0.53 7.5 0.38 6.03e-13 Response to temozolomide; CRC cis rs6831352 0.918 rs34936974 chr4:100052384 A/G cg12011299 chr4:100065546 ADH4 0.47 9.06 0.45 1.17e-17 Alcohol dependence; CRC cis rs2839186 0.706 rs2839188 chr21:47692798 C/T cg09417038 chr21:47716443 C21orf57 -0.41 -6.35 -0.33 6.97e-10 Testicular germ cell tumor; CRC cis rs6121246 0.609 rs2377317 chr20:30402502 A/G cg13852791 chr20:30311386 BCL2L1 -0.77 -15.48 -0.65 5.34e-41 Mean corpuscular hemoglobin; CRC cis rs713477 0.678 rs4901566 chr14:55912663 C/A cg13175173 chr14:55914753 NA -0.43 -7.73 -0.39 1.29e-13 Pediatric bone mineral content (femoral neck); CRC cis rs9916302 0.904 rs7223438 chr17:37521355 T/C cg00129232 chr17:37814104 STARD3 0.53 7.81 0.4 7.65e-14 Glomerular filtration rate (creatinine); CRC trans rs61931739 0.500 rs12146843 chr12:34451738 T/G cg26384229 chr12:38710491 ALG10B 0.62 9.08 0.45 1.04e-17 Morning vs. evening chronotype; CRC cis rs7666738 0.830 rs13111977 chr4:98953813 G/A cg05340658 chr4:99064831 C4orf37 0.61 9.54 0.47 3.45e-19 Colonoscopy-negative controls vs population controls; CRC cis rs7119 0.651 rs17394732 chr15:77835657 A/G cg27398640 chr15:77910606 LINGO1 0.4 6.84 0.35 3.92e-11 Type 2 diabetes; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg20304401 chr8:101733920 PABPC1 0.43 6.51 0.34 2.8e-10 Liver disease severity in Alagille syndrome; CRC cis rs9549367 0.713 rs4907593 chr13:113830459 C/T cg00898013 chr13:113819073 PROZ 0.5 7.45 0.38 8.43e-13 Platelet distribution width; CRC cis rs6951245 1.000 rs113066613 chr7:1094128 T/C cg26224354 chr7:1096374 C7orf50;GPR146 -0.94 -12.22 -0.56 1.4e-28 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs875971 0.522 rs10807697 chr7:65416170 A/G cg11764359 chr7:65958608 NA 0.52 7.8 0.4 8.25e-14 Aortic root size; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg05770837 chr13:45915717 LOC100190939;TPT1 0.46 5.99 0.31 5.59e-9 Thyroid stimulating hormone; CRC cis rs11212617 0.967 rs605394 chr11:108243628 C/T cg12106634 chr11:108092400 ATM;NPAT -0.4 -5.74 -0.3 2.11e-8 Response to metformin in type 2 diabetes (glycemic); CRC cis rs2012796 0.719 rs12434434 chr14:81826129 C/A cg02996355 chr14:81879375 NA 0.38 5.64 0.3 3.66e-8 Night sleep phenotypes; CRC cis rs7512552 0.698 rs12028001 chr1:150407820 C/T cg15654264 chr1:150340011 RPRD2 0.58 8.37 0.42 1.68e-15 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); CRC cis rs9287719 0.967 rs963831 chr2:10745184 T/C cg00105475 chr2:10696890 NA 0.45 7.21 0.37 3.91e-12 Prostate cancer; CRC cis rs7811142 0.830 rs78256546 chr7:99952970 A/G cg00814883 chr7:100076585 TSC22D4 -0.7 -8.77 -0.44 9.58e-17 Platelet count; CRC cis rs2243480 1.000 rs160646 chr7:65556280 C/T cg25985355 chr7:65971099 NA -0.47 -5.72 -0.3 2.39e-8 Diabetic kidney disease; CRC cis rs6951245 1.000 rs28528096 chr7:1070912 G/C cg04025307 chr7:1156635 C7orf50 0.63 6.63 0.34 1.41e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs10504229 0.639 rs72650811 chr8:58115661 G/A cg21724239 chr8:58056113 NA 0.49 6.81 0.35 4.75e-11 Developmental language disorder (linguistic errors); CRC cis rs10197940 0.662 rs10175134 chr2:152299355 G/A cg19508488 chr2:152266495 RIF1 0.59 8.33 0.42 2.17e-15 Lung cancer; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg13789711 chr9:139743225 PHPT1 0.48 6.11 0.32 2.75e-9 Thyroid stimulating hormone; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg06710349 chr5:139737425 NA 0.43 6.22 0.32 1.53e-9 Intelligence (multi-trait analysis); CRC cis rs8062405 0.824 rs4788083 chr16:28545449 A/G cg16576597 chr16:28551801 NUPR1 0.46 7.1 0.36 7.75e-12 Cognitive ability (multi-trait analysis);Cognitive ability; CRC cis rs8177253 0.829 rs9813689 chr3:133514822 C/T cg11941060 chr3:133502564 NA -0.65 -11.08 -0.52 1.78e-24 Iron status biomarkers; CRC cis rs2836974 0.666 rs2836975 chr21:40663620 A/G cg11890956 chr21:40555474 PSMG1 -0.9 -15.88 -0.66 1.53e-42 Cognitive function; CRC cis rs2836974 0.932 rs6517523 chr21:40557332 T/C cg17971929 chr21:40555470 PSMG1 0.82 11.62 0.54 2.27e-26 Cognitive function; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg00333034 chr3:183948058 VWA5B2 0.43 5.98 0.31 5.83e-9 Anxiety disorder; CRC cis rs2976388 0.609 rs2585152 chr8:143786214 A/T cg24046110 chr8:143859143 LYNX1 0.49 8.57 0.43 4.14e-16 Urinary tract infection frequency; CRC cis rs1707322 1.000 rs785470 chr1:46519622 C/A cg06784218 chr1:46089804 CCDC17 -0.55 -9.74 -0.47 7.37e-20 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs12048904 0.595 rs10493937 chr1:101342650 A/T cg00063077 chr1:101360652 SLC30A7;EXTL2 -0.68 -10.44 -0.5 3.18e-22 Multiple sclerosis; CRC cis rs11190604 0.943 rs9420792 chr10:102258439 C/T cg16342193 chr10:102329863 NA -0.36 -5.94 -0.31 7.18e-9 Palmitoleic acid (16:1n-7) levels; CRC cis rs10927875 0.541 rs1739843 chr1:16343254 T/C cg10494257 chr1:16342123 HSPB7 0.45 6.27 0.33 1.1e-9 Dilated cardiomyopathy; CRC cis rs853679 0.517 rs9380062 chr6:28137569 G/A cg02683197 chr6:28174875 NA 0.87 10.73 0.51 3.25e-23 Depression; CRC cis rs2067615 0.524 rs1882543 chr12:107067160 A/G cg13491945 chr12:107078410 RFX4 -0.33 -5.62 -0.3 4.15e-8 Heart rate; CRC cis rs12497850 0.931 rs7647813 chr3:48833348 G/T cg07636037 chr3:49044803 WDR6 1.02 18.52 0.71 5.84e-53 Parkinson's disease; CRC cis rs2976388 0.647 rs2572906 chr8:143798269 G/A cg12516270 chr8:143859308 LYNX1 0.42 7.46 0.38 7.65e-13 Urinary tract infection frequency; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg17955420 chr15:40987771 RAD51 0.45 6.38 0.33 6e-10 Response to antipsychotic treatment; CRC cis rs3768617 0.510 rs10797842 chr1:183081867 C/T ch.1.3577855R chr1:183094577 LAMC1 0.88 15.78 0.66 3.59e-42 Fuchs's corneal dystrophy; CRC cis rs7917772 0.560 rs3862030 chr10:104327584 A/G cg11453585 chr10:104263688 ACTR1A;SUFU 0.82 15.26 0.64 3.8e-40 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC cis rs9522267 0.559 rs9522300 chr13:112236668 C/G cg14352298 chr13:112236639 NA 0.29 6.74 0.35 7.32e-11 Hepatitis; CRC cis rs11971779 0.564 rs6467841 chr7:139066092 T/G cg23387468 chr7:139079360 LUC7L2 0.41 7.04 0.36 1.14e-11 Diisocyanate-induced asthma; CRC cis rs4604732 0.631 rs12038880 chr1:247624603 A/G cg12758973 chr1:247694275 LOC148824;OR2C3 0.48 6.74 0.35 6.98e-11 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CRC cis rs9462027 0.585 rs1201873 chr6:34550657 A/C cg07306190 chr6:34760872 UHRF1BP1 -0.34 -6.01 -0.31 4.82e-9 Systemic lupus erythematosus; CRC cis rs394563 0.690 rs237010 chr6:149758750 G/T cg16235748 chr6:149772707 ZC3H12D -0.39 -6.99 -0.36 1.5e-11 Dupuytren's disease; CRC cis rs7246865 0.859 rs11086052 chr19:17169081 G/A cg19418318 chr19:17219073 MYO9B 0.41 6.61 0.34 1.51e-10 Reticulocyte fraction of red cells; CRC cis rs4665809 1.000 rs2384321 chr2:26290054 A/G cg26119090 chr2:26468346 HADHA;HADHB -0.67 -8.27 -0.41 3.39e-15 Gut microbiome composition (summer); CRC cis rs7043114 0.525 rs10283572 chr9:95133074 G/A cg14631576 chr9:95140430 CENPP -0.3 -5.63 -0.3 3.78e-8 Height; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg08237663 chr3:130745839 NEK11;ASTE1 0.54 6.88 0.35 3.01e-11 Thyroid stimulating hormone; CRC trans rs1814175 0.817 rs1390676 chr11:50056778 C/T cg03929089 chr4:120376271 NA -0.93 -17.98 -0.7 7.84e-51 Height; CRC cis rs9875589 0.957 rs66716710 chr3:13938728 A/G cg19554555 chr3:13937349 NA 0.43 6.25 0.33 1.28e-9 Ovarian reserve; CRC trans rs7395662 0.525 rs4882060 chr11:48441874 G/C cg15704280 chr7:45808275 SEPT13 -0.48 -6.96 -0.36 1.88e-11 HDL cholesterol; CRC cis rs6000550 0.954 rs13055107 chr22:37469821 G/A cg07819160 chr22:37420328 MPST 0.5 5.61 0.3 4.25e-8 Mean corpuscular volume;Mean corpuscular hemoglobin;Red cell distribution width; CRC cis rs17376456 0.877 rs10057605 chr5:93443950 T/G cg09848695 chr5:92956644 FAM172A;MIR2277 0.64 5.92 0.31 8.15e-9 Diabetic retinopathy; CRC cis rs568617 0.953 rs1151519 chr11:65645831 G/C cg19792802 chr11:65647270 CTSW -0.5 -7.55 -0.38 4.23e-13 Crohn's disease; CRC cis rs4481887 0.927 rs4244187 chr1:248493511 T/C cg00666640 chr1:248458726 OR2T12 0.48 8.18 0.41 6.16e-15 Common traits (Other); CRC cis rs3820928 0.904 rs4439949 chr2:227764954 T/G cg11843606 chr2:227700838 RHBDD1 -0.41 -5.87 -0.31 1.05e-8 Pulmonary function; CRC trans rs11148252 0.595 rs4885117 chr13:53153027 T/C cg18335740 chr13:41363409 SLC25A15 0.74 13.52 0.6 2.06e-33 Lewy body disease; CRC cis rs1005277 0.563 rs2505216 chr10:38482830 T/C cg25517755 chr10:38738941 LOC399744 -0.44 -6.44 -0.33 4.31e-10 Extrinsic epigenetic age acceleration; CRC cis rs7772486 0.754 rs6937661 chr6:146113299 T/C cg13319975 chr6:146136371 FBXO30 0.46 6.67 0.35 1.07e-10 Lobe attachment (rater-scored or self-reported); CRC trans rs877282 0.853 rs12777155 chr10:754731 G/C cg22713356 chr15:30763199 NA 1.19 13.88 0.61 8.17e-35 Uric acid levels; CRC cis rs4713118 0.869 rs6930992 chr6:27712120 A/C cg08798685 chr6:27730294 NA -0.42 -6.26 -0.33 1.23e-9 Parkinson's disease; CRC trans rs1005277 0.565 rs2474565 chr10:38380828 A/G cg11292332 chr7:45801988 SEPT13 -0.35 -6.26 -0.33 1.17e-9 Extrinsic epigenetic age acceleration; CRC cis rs10046574 0.831 rs77819442 chr7:135072552 C/T cg27474649 chr7:135195673 CNOT4 0.7 5.67 0.3 3.12e-8 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs1552244 0.882 rs2130813 chr3:10038706 A/C cg02579736 chr3:10068473 FANCD2;CIDECP 0.96 12.39 0.56 3.4e-29 Alzheimer's disease; CRC cis rs17376456 0.825 rs12188163 chr5:93250608 A/G cg21475434 chr5:93447410 FAM172A -0.76 -7.32 -0.37 1.87e-12 Diabetic retinopathy; CRC cis rs10504229 0.683 rs66730544 chr8:58127280 A/T cg21724239 chr8:58056113 NA 0.49 6.81 0.35 4.75e-11 Developmental language disorder (linguistic errors); CRC cis rs1552244 0.882 rs67631672 chr3:10004768 G/A cg16606324 chr3:10149918 C3orf24 0.63 8.35 0.42 1.9e-15 Alzheimer's disease; CRC cis rs4731207 0.536 rs7792731 chr7:124653436 G/T cg23710748 chr7:124431027 NA -0.39 -6.25 -0.33 1.24e-9 Cutaneous malignant melanoma; CRC cis rs4665809 0.816 rs2384359 chr2:26371364 T/C cg25036284 chr2:26402008 FAM59B -0.52 -6.13 -0.32 2.48e-9 Gut microbiome composition (summer); CRC cis rs4660306 1.000 rs6429569 chr1:46001330 A/C cg03123370 chr1:45965343 CCDC163P;MMACHC -0.53 -7.72 -0.39 1.39e-13 Homocysteine levels; CRC cis rs763014 0.932 rs2269559 chr16:682297 T/C cg00908189 chr16:619842 PIGQ 0.64 10.21 0.49 1.91e-21 Height; CRC trans rs1005277 0.505 rs719569 chr10:38154415 T/G cg17830980 chr10:43048298 ZNF37B 0.41 6.35 0.33 7.32e-10 Extrinsic epigenetic age acceleration; CRC cis rs11229555 0.874 rs7102852 chr11:58358348 G/A cg15696309 chr11:58395628 NA -0.94 -12.66 -0.57 3.25e-30 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; CRC cis rs7584330 0.518 rs7585969 chr2:238439073 G/A cg14458575 chr2:238380390 NA 0.74 9.33 0.46 1.63e-18 Prostate cancer; CRC cis rs274567 0.501 rs272855 chr5:131687175 C/T cg24060327 chr5:131705240 SLC22A5 -0.5 -7.22 -0.37 3.62e-12 Blood metabolite levels; CRC cis rs2290159 0.800 rs5746187 chr3:12659419 A/G cg23032965 chr3:12705835 RAF1 0.49 6.31 0.33 9.24e-10 Cholesterol, total; CRC cis rs1552244 1.000 rs7615764 chr3:10082592 C/T cg13047869 chr3:10149882 C3orf24 0.57 7.76 0.39 1.1e-13 Alzheimer's disease; CRC cis rs12220238 1.000 rs11000887 chr10:75897542 C/T cg19889307 chr10:75911429 ADK;AP3M1 0.64 6.27 0.33 1.11e-9 Soluble interleukin-2 receptor subunit alpha; CRC cis rs7659604 1.000 rs34952897 chr4:122664409 C/T cg19748678 chr4:122722346 EXOSC9 0.56 9.01 0.44 1.78e-17 Type 2 diabetes; CRC cis rs1707322 1.000 rs785478 chr1:46491635 C/T cg03146154 chr1:46216737 IPP -0.49 -6.88 -0.35 2.98e-11 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs13108904 0.935 rs2199956 chr4:1248919 A/G cg19318889 chr4:1322082 MAEA 0.44 6.5 0.34 2.89e-10 Obesity-related traits; CRC trans rs1814175 0.585 rs4881661 chr11:50000117 A/G cg03929089 chr4:120376271 NA -0.88 -15.84 -0.66 2.09e-42 Height; CRC cis rs9903692 0.865 rs7220520 chr17:46167942 A/G cg21215337 chr17:46176117 CBX1 0.44 8.38 0.42 1.56e-15 Pulse pressure; CRC cis rs17767392 0.958 rs61989377 chr14:71957362 C/T cg13720639 chr14:72061746 SIPA1L1 -0.57 -7.23 -0.37 3.5e-12 Mitral valve prolapse; CRC cis rs7224685 0.501 rs781848 chr17:3958105 A/C cg09597638 chr17:3907349 NA 0.64 11.08 0.52 1.83e-24 Type 2 diabetes; CRC cis rs968567 0.539 rs174556 chr11:61580635 C/T cg00603274 chr11:61596626 FADS2 -0.49 -6.92 -0.36 2.42e-11 Blood metabolite levels;Rheumatoid arthritis;Vitiligo;Glycerophospholipid levels; CRC cis rs9715521 0.867 rs6840137 chr4:59830872 A/G cg11281224 chr4:60001000 NA -0.38 -5.74 -0.3 2.19e-8 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC trans rs2228479 0.702 rs11076620 chr16:89831520 A/T cg24644049 chr4:85504048 CDS1 0.87 7.08 0.36 8.68e-12 Skin colour saturation; CRC cis rs427941 0.703 rs201454 chr7:101740056 A/G cg06246474 chr7:101738831 CUX1 0.46 7.24 0.37 3.2e-12 Plasma omega-3 polyunsaturated fatty acid level (eicosapentaenoic acid); CRC cis rs6952808 0.823 rs58222895 chr7:1885064 G/A cg20295408 chr7:1910781 MAD1L1 -0.44 -6.37 -0.33 6.41e-10 Bipolar disorder and schizophrenia; CRC cis rs8077889 0.917 rs72836559 chr17:41913529 C/T cg25876840 chr17:41920477 NA 0.62 8.55 0.43 4.6e-16 Triglycerides; CRC trans rs1814175 0.740 rs10839439 chr11:49918240 C/T cg15704280 chr7:45808275 SEPT13 -0.97 -18.83 -0.72 3.33e-54 Height; CRC cis rs11792861 0.816 rs2275637 chr9:111696043 C/G cg05043794 chr9:111880884 C9orf5 -0.33 -5.77 -0.3 1.82e-8 Menarche (age at onset); CRC cis rs752010 0.714 rs7515948 chr1:42079046 T/G cg06885757 chr1:42089581 HIVEP3 0.46 8.34 0.42 2.06e-15 Lupus nephritis in systemic lupus erythematosus; CRC trans rs1814175 0.645 rs7123448 chr11:49764865 T/G cg15704280 chr7:45808275 SEPT13 -0.96 -16.89 -0.68 1.61e-46 Height; CRC cis rs6502050 1.000 rs6502050 chr17:80058236 C/G cg13198984 chr17:80129470 CCDC57 -0.46 -8.0 -0.4 2.13e-14 Life satisfaction; CRC cis rs2839186 0.526 rs59977673 chr21:47922091 C/T cg11766577 chr21:47581405 C21orf56 -0.4 -6.24 -0.33 1.33e-9 Testicular germ cell tumor; CRC cis rs7429990 0.932 rs13085054 chr3:48134137 C/T cg11946769 chr3:48343235 NME6 -0.44 -5.88 -0.31 1.02e-8 Educational attainment (years of education); CRC cis rs7937682 0.889 rs3017767 chr11:111508098 A/G cg19812747 chr11:111475976 SIK2 -0.59 -10.07 -0.49 5.54e-21 Primary sclerosing cholangitis; CRC cis rs1048238 0.846 rs945420 chr1:16345208 G/A cg24140574 chr1:16342155 HSPB7 0.43 6.26 0.33 1.22e-9 Systolic blood pressure; CRC cis rs28386778 0.901 rs2854194 chr17:61952110 T/G cg22520471 chr17:61851767 DDX42;CCDC47 0.74 11.47 0.53 7.29e-26 Prudent dietary pattern; CRC cis rs7666738 0.830 rs10007872 chr4:99001904 T/C cg17366294 chr4:99064904 C4orf37 0.43 7.27 0.37 2.66e-12 Colonoscopy-negative controls vs population controls; CRC cis rs524281 0.861 rs11227409 chr11:65870938 A/G cg14036092 chr11:66035641 RAB1B -0.47 -5.73 -0.3 2.29e-8 Electroencephalogram traits; CRC cis rs7647973 0.731 rs13084037 chr3:49214066 G/A cg07636037 chr3:49044803 WDR6 0.57 6.2 0.32 1.71e-9 Menarche (age at onset); CRC cis rs736408 0.521 rs13074853 chr3:52779801 T/C cg15147215 chr3:52552868 STAB1 -0.63 -10.74 -0.51 2.95e-23 Bipolar disorder; CRC cis rs7259376 0.902 rs8112041 chr19:22604565 C/T cg02657401 chr19:22469223 NA 0.3 6.59 0.34 1.8e-10 Menopause (age at onset); CRC cis rs2976388 0.609 rs1469811 chr8:143787999 C/T cg04969067 chr8:143858791 LYNX1 0.45 7.57 0.39 3.86e-13 Urinary tract infection frequency; CRC cis rs9393692 0.620 rs6930616 chr6:26331969 A/G cg13736514 chr6:26305472 NA -0.46 -7.63 -0.39 2.53e-13 Educational attainment; CRC cis rs3741404 0.672 rs4980524 chr11:63959259 A/C cg15107132 chr11:63991130 FERMT3 -0.36 -5.91 -0.31 8.32e-9 Platelet count; CRC trans rs7267979 1.000 rs4815426 chr20:25405186 A/C cg17903999 chr18:56338584 MALT1 0.42 7.06 0.36 9.77e-12 Liver enzyme levels (alkaline phosphatase); CRC cis rs769267 0.965 rs735273 chr19:19385411 T/C cg02546618 chr19:19431379 KIAA0892;SF4 0.46 6.3 0.33 9.31e-10 Tonsillectomy; CRC cis rs1003719 0.646 rs2835671 chr21:38581125 T/G cg10648535 chr21:38446584 PIGP;TTC3 -0.45 -6.28 -0.33 1.05e-9 Eye color traits; CRC cis rs17376456 0.825 rs7715562 chr5:93222034 C/T cg21475434 chr5:93447410 FAM172A -0.72 -7.11 -0.36 7.33e-12 Diabetic retinopathy; CRC cis rs4073416 0.542 rs6573614 chr14:65958703 G/A cg03016385 chr14:66212404 NA -0.4 -5.66 -0.3 3.31e-8 N-glycan levels; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg04804616 chr16:30622014 ZNF689 0.52 6.59 0.34 1.78e-10 Thyroid stimulating hormone; CRC cis rs735539 0.718 rs7985552 chr13:21280738 A/T cg27499820 chr13:21296301 IL17D -0.4 -6.23 -0.32 1.46e-9 Dental caries; CRC cis rs28386778 0.687 rs59596917 chr17:61806264 T/A cg22520471 chr17:61851767 DDX42;CCDC47 0.73 11.17 0.52 9.08e-25 Prudent dietary pattern; CRC cis rs3820928 0.874 rs4675133 chr2:227843010 A/G cg11843606 chr2:227700838 RHBDD1 0.4 5.91 0.31 8.78e-9 Pulmonary function; CRC trans rs3960554 0.709 rs73138006 chr7:75769990 T/C cg19862616 chr7:65841803 NCRNA00174 0.77 9.16 0.45 5.74e-18 Eotaxin levels; CRC cis rs9916302 0.898 rs8072297 chr17:37478048 A/T cg07936489 chr17:37558343 FBXL20 0.84 12.72 0.57 1.98e-30 Glomerular filtration rate (creatinine); CRC cis rs4713118 0.513 rs156739 chr6:28013410 C/A cg15845792 chr6:28175446 NA 0.77 11.38 0.53 1.54e-25 Parkinson's disease; CRC cis rs3741404 0.583 rs640999 chr11:63869425 C/A cg05016508 chr11:63871570 FLRT1;MACROD1 0.53 8.87 0.44 4.6e-17 Platelet count; CRC cis rs12291225 0.585 rs11023194 chr11:14369769 T/C cg19336497 chr11:14380999 RRAS2 -0.52 -9.21 -0.45 3.81e-18 Sense of smell; CRC cis rs1113500 0.702 rs11185262 chr1:108639742 C/T cg06207961 chr1:108661230 NA 0.39 5.75 0.3 2.07e-8 Growth-regulated protein alpha levels; CRC cis rs910316 0.737 rs108621 chr14:75480637 T/C cg03030879 chr14:75389066 RPS6KL1 0.42 6.4 0.33 5.21e-10 Height; CRC cis rs9649213 0.593 rs6465665 chr7:97934150 T/C cg24562669 chr7:97807699 LMTK2 0.41 6.85 0.35 3.6e-11 Prostate cancer (SNP x SNP interaction); CRC cis rs13315871 0.929 rs73835170 chr3:58318448 A/G cg20936604 chr3:58311152 NA -0.75 -7.68 -0.39 1.87e-13 Cholesterol, total; CRC cis rs9435341 0.896 rs1730850 chr1:107597988 C/T cg11070056 chr1:107600091 PRMT6 -0.42 -6.05 -0.32 3.95e-9 Facial morphology (factor 21, depth of nasal alae); CRC cis rs4363385 0.818 rs684305 chr1:153006242 G/A cg25856811 chr1:152973957 SPRR3 -0.25 -6.99 -0.36 1.51e-11 Inflammatory skin disease; CRC cis rs116095464 0.558 rs10075018 chr5:239175 G/A cg22857025 chr5:266934 NA -1.25 -16.75 -0.68 5.7e-46 Breast cancer; CRC cis rs8077889 0.917 rs9901676 chr17:41911818 T/C cg16892393 chr17:41919603 NA 0.47 7.12 0.37 6.81e-12 Triglycerides; CRC cis rs709400 0.604 rs7158144 chr14:103887615 A/G cg12935359 chr14:103987150 CKB -0.52 -8.02 -0.4 1.83e-14 Body mass index; CRC cis rs28374715 0.617 rs16971735 chr15:41563970 C/G cg18705301 chr15:41695430 NDUFAF1 -0.51 -8.57 -0.43 3.95e-16 Ulcerative colitis; CRC cis rs10256972 0.616 rs4998392 chr7:1113344 A/C cg18402987 chr7:1209562 NA 0.44 6.53 0.34 2.49e-10 Longevity;Endometriosis; CRC cis rs7618915 0.547 rs8906 chr3:52739520 T/C cg18404041 chr3:52824283 ITIH1 -0.43 -8.73 -0.43 1.26e-16 Bipolar disorder; CRC cis rs853679 0.517 rs9393901 chr6:28136797 A/G cg15845792 chr6:28175446 NA 1.04 13.89 0.61 7.67e-35 Depression; CRC cis rs7959452 0.562 rs11177630 chr12:69767963 G/C cg14784868 chr12:69753453 YEATS4 0.84 14.84 0.63 1.73e-38 Blood protein levels; CRC cis rs7647973 0.710 rs1532204 chr3:49609477 C/G cg13072238 chr3:49761600 GMPPB -0.54 -5.85 -0.31 1.19e-8 Menarche (age at onset); CRC trans rs9929218 0.953 rs9927329 chr16:68750331 C/T cg04657470 chr2:198365150 HSPE1;HSPD1 -0.99 -14.55 -0.63 2.15e-37 Colorectal cancer; CRC trans rs2303319 0.504 rs1023835 chr2:162593973 A/G cg23247704 chr1:116518985 SLC22A15 -0.72 -6.14 -0.32 2.42e-9 Cognitive function; CRC cis rs2204008 0.693 rs12372025 chr12:38202028 G/A cg26384229 chr12:38710491 ALG10B 0.69 9.22 0.45 3.54e-18 Bladder cancer; CRC cis rs12541635 0.677 rs6469032 chr8:107057509 A/T cg10147462 chr8:107024639 NA 0.63 11.34 0.53 2.23e-25 Age of smoking initiation; CRC cis rs12497850 0.644 rs11928552 chr3:48739883 T/C cg07636037 chr3:49044803 WDR6 0.91 15.22 0.64 5.41e-40 Parkinson's disease; CRC trans rs6500957 0.920 rs17648524 chr16:7459683 C/G cg00622528 chr6:41040237 C6orf130;NFYA 0.42 6.17 0.32 1.99e-9 Spherical equivalent (joint analysis main effects and education interaction); CRC cis rs4689388 0.890 rs11732208 chr4:6292716 G/C cg14416269 chr4:6271139 WFS1 0.39 6.55 0.34 2.25e-10 Type 2 diabetes and other traits;Type 2 diabetes; CRC cis rs8044995 0.706 rs111948678 chr16:68255959 G/A cg09835421 chr16:68378352 PRMT7 -0.6 -5.76 -0.3 1.93e-8 Schizophrenia; CRC cis rs6582630 0.555 rs35186318 chr12:38295822 C/T cg26384229 chr12:38710491 ALG10B -0.52 -7.56 -0.38 3.96e-13 Drug-induced liver injury (flucloxacillin); CRC trans rs61931739 0.500 rs11053185 chr12:34428857 A/G cg26384229 chr12:38710491 ALG10B 0.59 8.82 0.44 6.92e-17 Morning vs. evening chronotype; CRC cis rs11122272 0.735 rs2572248 chr1:231514942 A/G cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.54 -8.11 -0.41 1.04e-14 Hemoglobin concentration; CRC cis rs9325144 0.625 rs12227353 chr12:38734542 C/T cg26384229 chr12:38710491 ALG10B -0.56 -8.28 -0.42 3.19e-15 Morning vs. evening chronotype; CRC cis rs6691722 0.506 rs12030365 chr1:24739220 T/A cg18323236 chr1:24743029 NIPAL3 0.48 7.48 0.38 6.75e-13 Response to interferon beta in multiple sclerosis; CRC cis rs908922 0.676 rs11205014 chr1:152483634 C/T cg23254163 chr1:152506842 NA 0.49 9.78 0.47 5.49e-20 Hair morphology; CRC cis rs2282526 0.615 rs463738 chr21:44921166 G/A cg01579765 chr21:45077557 HSF2BP 0.34 5.78 0.3 1.75e-8 Mean corpuscular hemoglobin; CRC cis rs2046867 0.862 rs62252360 chr3:72838551 C/T cg25664220 chr3:72788482 NA -0.41 -6.2 -0.32 1.71e-9 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; CRC cis rs796364 1.000 rs796364 chr2:200716119 C/A cg25936922 chr2:200820526 C2orf60;C2orf47 0.7 7.69 0.39 1.67e-13 Schizophrenia; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg24265806 chr7:23053737 FAM126A 0.35 6.45 0.34 3.99e-10 Intelligence (multi-trait analysis); CRC cis rs17253792 0.822 rs17253730 chr14:56157911 A/G cg01858014 chr14:56050164 KTN1 -0.87 -7.03 -0.36 1.17e-11 Putamen volume; CRC cis rs9649213 0.593 rs6969731 chr7:97924571 T/G cg24562669 chr7:97807699 LMTK2 0.42 7.01 0.36 1.39e-11 Prostate cancer (SNP x SNP interaction); CRC cis rs9393692 0.645 rs766407 chr6:26319534 T/C cg13736514 chr6:26305472 NA -0.66 -11.6 -0.54 2.63e-26 Educational attainment; CRC trans rs7615952 0.546 rs2979340 chr3:125341384 C/T cg21747405 chr11:67723411 NA -0.49 -6.32 -0.33 8.59e-10 Blood pressure (smoking interaction); CRC cis rs2404602 0.692 rs34478400 chr15:76923510 C/T cg03037974 chr15:76606532 NA 0.7 12.32 0.56 6.18e-29 Blood metabolite levels; CRC cis rs524281 0.684 rs7946447 chr11:65864338 T/C cg16950941 chr11:66035639 RAB1B -0.58 -7.41 -0.38 1.06e-12 Electroencephalogram traits; CRC cis rs9309473 1.000 rs6755241 chr2:73641364 C/T cg20560298 chr2:73613845 ALMS1 -0.5 -6.18 -0.32 1.92e-9 Metabolite levels; CRC cis rs2072499 0.966 rs6427307 chr1:156190083 A/G cg06970220 chr1:156163860 SLC25A44 0.52 7.51 0.38 5.47e-13 Testicular germ cell tumor; CRC cis rs28386778 1.000 rs28386778 chr17:61964815 T/C cg06601766 chr17:61851465 DDX42;CCDC47 0.46 6.09 0.32 3.24e-9 Prudent dietary pattern; CRC cis rs713477 0.505 rs8019080 chr14:55891372 C/T cg13175173 chr14:55914753 NA -0.44 -7.13 -0.37 6.42e-12 Pediatric bone mineral content (femoral neck); CRC cis rs9914988 0.943 rs7215310 chr17:27088626 G/T cg12682573 chr17:27188876 MIR451;MIR144 0.53 7.64 0.39 2.35e-13 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs2070488 0.965 rs2126534 chr3:38445165 T/G cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.9 16.32 0.67 2.75e-44 Electrocardiographic conduction measures; CRC cis rs875971 0.862 rs4149461 chr7:65744732 T/C cg18876405 chr7:65276391 NA -0.5 -8.29 -0.42 2.87e-15 Aortic root size; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg01297674 chr2:122406765 CLASP1 0.48 6.7 0.35 9.22e-11 Response to antipsychotic treatment; CRC trans rs2303319 0.504 rs56100249 chr2:162415157 T/C cg09481857 chr22:21368659 P2RX6;MGC16703 -0.66 -6.15 -0.32 2.21e-9 Cognitive function; CRC cis rs6496667 0.779 rs7163560 chr15:91038620 A/T cg04176472 chr15:90893244 GABARAPL3 0.53 7.72 0.39 1.37e-13 Rheumatoid arthritis; CRC cis rs13082711 0.911 rs3755652 chr3:27472936 A/G cg02860705 chr3:27208620 NA -0.62 -9.02 -0.45 1.64e-17 Systolic blood pressure;Diastolic blood pressure;Blood pressure; CRC cis rs7826238 0.623 rs2976893 chr8:8338219 G/T cg06636001 chr8:8085503 FLJ10661 -0.53 -8.04 -0.41 1.68e-14 Systolic blood pressure; CRC cis rs10504229 0.775 rs55764517 chr8:58158238 G/A cg02725872 chr8:58115012 NA -0.59 -9.18 -0.45 4.97e-18 Developmental language disorder (linguistic errors); CRC cis rs9303401 1.000 rs6503882 chr17:56915761 T/C cg10487724 chr17:56770010 TEX14;RAD51C 0.56 8.16 0.41 7.3e-15 Cognitive test performance; CRC cis rs11997175 0.646 rs4733177 chr8:33691754 A/G ch.8.33884649F chr8:33765107 NA 0.45 6.48 0.34 3.31e-10 Body mass index; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg14455487 chr1:42800860 FOXJ3 0.44 6.18 0.32 1.89e-9 Anxiety disorder; CRC cis rs13108904 0.875 rs73069950 chr4:1276045 C/A cg20887711 chr4:1340912 KIAA1530 -0.44 -6.38 -0.33 6.07e-10 Obesity-related traits; CRC cis rs2153535 0.601 rs2015281 chr6:8539673 G/A cg07606381 chr6:8435919 SLC35B3 0.69 11.29 0.53 3.23e-25 Motion sickness; CRC cis rs12497850 0.931 rs4974082 chr3:48999323 G/A cg07636037 chr3:49044803 WDR6 1.03 18.54 0.71 4.77e-53 Parkinson's disease; CRC trans rs12517041 1.000 rs2099091 chr5:23295532 T/A ch.8.1293020R chr8:59333349 UBXN2B -0.55 -6.17 -0.32 2.05e-9 Calcium levels; CRC cis rs6076065 0.676 rs6076057 chr20:23335982 G/T cg11657817 chr20:23433608 CST11 -0.5 -7.33 -0.37 1.79e-12 Facial morphology (factor 15, philtrum width); CRC cis rs7809950 1.000 rs2520277 chr7:107130234 C/T cg23024343 chr7:107201750 COG5 -0.6 -8.59 -0.43 3.44e-16 Coronary artery disease; CRC cis rs7523050 0.643 rs17621851 chr1:109400835 C/T cg08274380 chr1:109419600 GPSM2 0.84 6.6 0.34 1.69e-10 Fat distribution (HIV); CRC cis rs1448094 0.512 rs6539932 chr12:86247497 T/C cg00310523 chr12:86230176 RASSF9 0.34 5.71 0.3 2.58e-8 Major depressive disorder; CRC cis rs3764400 0.567 rs12936369 chr17:46270696 C/T cg10706073 chr17:46328419 SKAP1 -0.61 -6.7 -0.35 8.9e-11 Body mass index; CRC cis rs9916302 0.904 rs1077715 chr17:37683548 A/T cg03013999 chr17:37608204 MED1 0.45 6.97 0.36 1.77e-11 Glomerular filtration rate (creatinine); CRC cis rs1008375 0.966 rs10939758 chr4:17698255 C/T cg16339924 chr4:17578868 LAP3 0.49 6.51 0.34 2.8e-10 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs7811142 0.830 rs11771936 chr7:99943283 A/G cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.64 8.09 0.41 1.19e-14 Platelet count; CRC cis rs9910055 0.573 rs228768 chr17:42191893 A/C cg13607699 chr17:42295918 UBTF 0.54 7.44 0.38 8.64e-13 Total body bone mineral density; CRC cis rs556990 0.570 rs5960 chr13:113801737 C/T cg18105134 chr13:113819100 PROZ 0.53 6.89 0.35 2.9100000000000002e-11 Blood protein levels; CRC cis rs7937682 0.889 rs11213971 chr11:111529829 A/G cg09085632 chr11:111637200 PPP2R1B -1.02 -20.96 -0.76 1.47e-62 Primary sclerosing cholangitis; CRC cis rs12286929 0.600 rs4445669 chr11:115045237 C/T cg04055981 chr11:115044050 NA -0.4 -6.45 -0.33 4.04e-10 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC trans rs1814175 0.791 rs10769625 chr11:49869887 G/A cg21153622 chr11:89784906 NA -0.38 -6.04 -0.32 4.27e-9 Height; CRC cis rs561341 0.714 rs111760509 chr17:30304320 A/G cg12193833 chr17:30244370 NA -0.75 -8.75 -0.43 1.16e-16 Hip circumference adjusted for BMI; CRC cis rs1552244 1.000 rs7610821 chr3:10136150 C/T cg16606324 chr3:10149918 C3orf24 0.69 9.67 0.47 1.25e-19 Alzheimer's disease; CRC cis rs6424115 0.830 rs2501425 chr1:24199339 A/C cg15997130 chr1:24165203 NA 0.72 10.6 0.5 9.06e-23 Immature fraction of reticulocytes; CRC cis rs769267 0.825 rs1469713 chr19:19528806 A/G cg03709012 chr19:19516395 GATAD2A 0.72 11.3 0.53 3.14e-25 Tonsillectomy; CRC cis rs9611519 0.964 rs2092563 chr22:41592677 G/A cg03806693 chr22:41940476 POLR3H -0.61 -7.68 -0.39 1.88e-13 Neuroticism; CRC cis rs7264396 1.000 rs6060479 chr20:34165723 A/C cg04508476 chr20:34239394 CPNE1;RBM12 0.45 7.33 0.37 1.74e-12 Total cholesterol levels; CRC cis rs9487051 0.872 rs9386791 chr6:109608497 C/T cg01475377 chr6:109611718 NA -0.49 -9.22 -0.45 3.62e-18 Reticulocyte fraction of red cells; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg10954261 chr6:11094075 LOC221710 0.46 6.14 0.32 2.35e-9 Thyroid stimulating hormone; CRC cis rs6502050 0.835 rs4499294 chr17:80148346 C/T cg25804541 chr17:80189381 SLC16A3 -0.31 -5.9 -0.31 8.81e-9 Life satisfaction; CRC cis rs2070488 1.000 rs3792527 chr3:38493212 T/C cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.91 17.03 0.68 4.35e-47 Electrocardiographic conduction measures; CRC cis rs10504229 0.817 rs114173899 chr8:58170640 G/T cg01721255 chr8:58191610 C8orf71 0.51 6.33 0.33 7.92e-10 Developmental language disorder (linguistic errors); CRC cis rs2074585 0.708 rs2589939 chr15:90930875 C/T cg22089800 chr15:90895588 ZNF774 0.59 9.86 0.48 2.95e-20 Basophil percentage of granulocytes;White blood cell count (basophil);Basophil percentage of white cells; CRC cis rs9611519 0.761 rs35445172 chr22:41660301 G/A cg06634786 chr22:41940651 POLR3H -0.43 -5.81 -0.31 1.46e-8 Neuroticism; CRC cis rs815815 0.583 rs878665 chr2:47403129 G/T cg27223769 chr2:47403360 CALM2 -0.55 -7.35 -0.38 1.57e-12 Dialysis-related mortality; CRC cis rs2842992 0.513 rs7759086 chr6:160193853 A/G cg19482086 chr6:160211437 TCP1;MRPL18 0.83 13.49 0.6 2.56e-33 Age-related macular degeneration (geographic atrophy); CRC cis rs9486719 1.000 rs9373978 chr6:97056255 T/C cg06623918 chr6:96969491 KIAA0776 -0.82 -9.59 -0.47 2.33e-19 Migraine;Coronary artery disease; CRC cis rs72717009 0.825 rs12722986 chr1:161465420 A/G cg10431340 chr1:161279108 MPZ -0.55 -7.39 -0.38 1.23e-12 Rheumatoid arthritis; CRC cis rs10927875 0.691 rs1048302 chr1:16340879 T/G cg10494257 chr1:16342123 HSPB7 0.44 5.7 0.3 2.67e-8 Dilated cardiomyopathy; CRC trans rs951252 0.504 rs11734405 chr4:146081096 C/T cg16280098 chr14:23790882 PABPN1 0.46 6.43 0.33 4.6e-10 Hip circumference; CRC cis rs6076065 0.748 rs2281431 chr20:23399304 C/G cg11657817 chr20:23433608 CST11 0.53 8.83 0.44 6.34e-17 Facial morphology (factor 15, philtrum width); CRC cis rs7208859 0.623 rs77544470 chr17:28934550 C/A cg19761014 chr17:28927070 LRRC37B2 0.59 5.88 0.31 1.02e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg25595571 chr14:104029029 BAG5;C14orf153 0.43 7.01 0.36 1.34e-11 Liver disease severity in Alagille syndrome; CRC cis rs8072100 0.744 rs34537623 chr17:45530203 A/G cg08085267 chr17:45401833 C17orf57 -0.66 -10.87 -0.51 1.01e-23 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs9318086 0.753 rs9553094 chr13:24474613 A/G cg25267304 chr13:24462978 PCOTH;MIPEP -0.57 -9.3 -0.46 2.01e-18 Myopia (pathological); CRC cis rs1005277 0.579 rs1740747 chr10:38520465 G/A cg00409905 chr10:38381863 ZNF37A -0.62 -10.29 -0.49 1.04e-21 Extrinsic epigenetic age acceleration; CRC cis rs4728302 0.838 rs2042453 chr7:133580730 G/A cg03336402 chr7:133662267 EXOC4 -0.44 -6.37 -0.33 6.53e-10 Intelligence;Intelligence (multi-trait analysis); CRC cis rs6693567 0.565 rs11205373 chr1:150404708 A/G cg15654264 chr1:150340011 RPRD2 0.38 5.92 0.31 8.09e-9 Migraine; CRC cis rs11209185 0.509 rs9436791 chr1:68452857 A/C cg22082780 chr1:68452167 NA 0.49 7.77 0.39 9.9e-14 Itch intensity from mosquito bite adjusted by bite size; CRC cis rs763014 0.932 rs2269560 chr16:682442 A/C cg00802000 chr16:706648 WDR90 -0.41 -5.84 -0.31 1.22e-8 Height; CRC cis rs11785693 0.862 rs13281354 chr8:4987756 G/T cg26367366 chr8:4980734 NA 0.89 10.92 0.52 6.84e-24 Neuroticism (multi-trait analysis);Neuroticism; CRC cis rs10927875 0.541 rs1763607 chr1:16337509 G/A cg22431228 chr1:16359049 CLCNKA -0.38 -6.91 -0.36 2.45e-11 Dilated cardiomyopathy; CRC cis rs561341 0.700 rs6505266 chr17:30225813 G/A cg13647721 chr17:30228624 UTP6 0.63 8.06 0.41 1.45e-14 Hip circumference adjusted for BMI; CRC cis rs4474465 1.000 rs11237499 chr11:78163164 A/T cg27205649 chr11:78285834 NARS2 -0.47 -5.89 -0.31 9.57e-9 Alzheimer's disease (survival time); CRC cis rs4423214 1.000 rs4944946 chr11:71159429 G/A cg05163923 chr11:71159392 DHCR7 0.68 9.77 0.47 5.75e-20 Vitamin D levels; CRC cis rs8105895 0.877 rs28822164 chr19:22245108 C/A cg02657401 chr19:22469223 NA -0.34 -5.67 -0.3 3.15e-8 Body mass index (change over time); CRC cis rs11690935 0.959 rs77280952 chr2:172620151 G/C cg13550731 chr2:172543902 DYNC1I2 -1.07 -17.28 -0.69 4.62e-48 Schizophrenia; CRC cis rs10479542 0.784 rs6896940 chr5:178985994 G/C cg22764044 chr5:178986830 RUFY1 0.43 7.46 0.38 7.78e-13 Lung cancer; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg14546197 chr17:38137043 PSMD3 0.41 6.27 0.33 1.11e-9 Intelligence (multi-trait analysis); CRC cis rs597539 0.652 rs482172 chr11:68668437 C/A cg04772025 chr11:68637568 NA 0.48 7.41 0.38 1.09e-12 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs501120 1.000 rs694425 chr10:44761804 C/G cg09554077 chr10:44749378 NA 0.73 10.64 0.51 6.55e-23 Coronary artery disease;Coronary heart disease; CRC cis rs425277 1.000 rs262672 chr1:2080813 G/T cg24578937 chr1:2090814 PRKCZ 0.66 11.79 0.54 5.46e-27 Height; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg04480227 chr20:61904058 ARFGAP1 0.41 6.15 0.32 2.27e-9 Response to antipsychotic treatment; CRC cis rs12701220 0.847 rs10272002 chr7:1047615 A/G cg02733842 chr7:1102375 C7orf50 -0.83 -9.96 -0.48 1.37e-20 Bronchopulmonary dysplasia; CRC cis rs2797160 1.000 rs1739373 chr6:126011509 A/G cg05901451 chr6:126070800 HEY2 0.41 6.2 0.32 1.66e-9 Endometrial cancer; CRC cis rs7258465 0.965 rs8100767 chr19:18589088 T/C cg06953865 chr19:18549723 ISYNA1 -0.38 -5.8 -0.3 1.55e-8 Breast cancer; CRC cis rs2742417 0.603 rs2742457 chr3:45767487 G/A cg04837898 chr3:45731254 SACM1L -0.49 -7.74 -0.39 1.21e-13 Response to anti-depressant treatment in major depressive disorder; CRC cis rs6691722 0.503 rs3765428 chr1:24706113 G/A cg02336364 chr1:24764700 NIPAL3 0.37 6.22 0.32 1.53e-9 Response to interferon beta in multiple sclerosis; CRC cis rs2559856 1.000 rs2695298 chr12:102082589 G/A cg12924262 chr12:102091054 CHPT1 0.56 8.4 0.42 1.33e-15 Blood protein levels; CRC cis rs370915 0.963 rs59452206 chr4:187816484 G/T cg12892747 chr4:187813459 NA -0.41 -6.02 -0.32 4.62e-9 Gout; CRC cis rs13118159 0.899 rs3796613 chr4:1353321 A/T cg20092199 chr4:1342459 KIAA1530 0.43 7.6 0.39 3.17e-13 Longevity; CRC cis rs4927850 1.000 rs7625570 chr3:195747398 A/G cg00031303 chr3:195681400 NA 0.51 7.22 0.37 3.63e-12 Pancreatic cancer; CRC cis rs9311474 0.607 rs34005367 chr3:52558904 A/T cg10802521 chr3:52805072 NEK4 -0.52 -8.02 -0.4 1.91e-14 Electroencephalogram traits; CRC cis rs300703 0.604 rs373375 chr2:203350 C/A cg21211680 chr2:198530 NA 0.89 11.89 0.55 2.31e-27 Blood protein levels; CRC trans rs7819412 0.521 rs11777887 chr8:11036799 C/G cg06636001 chr8:8085503 FLJ10661 0.47 6.82 0.35 4.44e-11 Triglycerides; CRC cis rs72634258 0.786 rs12563704 chr1:8033837 G/A cg00042356 chr1:8021962 PARK7 0.63 7.17 0.37 4.84e-12 Inflammatory bowel disease; CRC cis rs9818758 0.607 rs35108630 chr3:49088356 T/A cg07636037 chr3:49044803 WDR6 -0.82 -6.7 -0.35 9.21e-11 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; CRC cis rs7618915 0.571 rs34115864 chr3:52612178 A/G cg10802521 chr3:52805072 NEK4 -0.58 -9.01 -0.44 1.68e-17 Bipolar disorder; CRC trans rs1005277 0.579 rs2474587 chr10:38420666 C/T cg17830980 chr10:43048298 ZNF37B -0.58 -9.74 -0.47 7.57e-20 Extrinsic epigenetic age acceleration; CRC cis rs734999 0.588 rs2843402 chr1:2528682 T/C cg18854424 chr1:2615690 NA -0.42 -8.07 -0.41 1.3e-14 Ulcerative colitis; CRC cis rs7215564 0.908 rs2316059 chr17:78663732 C/T cg09596252 chr17:78655493 RPTOR 0.56 6.11 0.32 2.76e-9 Myopia (pathological); CRC cis rs4964805 1.000 rs4964805 chr12:104192824 C/G cg02344784 chr12:104178138 NT5DC3 0.55 8.27 0.41 3.28e-15 Attention deficit hyperactivity disorder; CRC cis rs9858542 0.953 rs9859556 chr3:49455986 G/T cg03060546 chr3:49711283 APEH -0.49 -6.82 -0.35 4.42e-11 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs17401966 1.000 rs11576866 chr1:10414432 A/G cg19773385 chr1:10388646 KIF1B -0.57 -7.57 -0.39 3.7e-13 Hepatocellular carcinoma; CRC trans rs2018683 0.700 rs13227954 chr7:29017188 A/C cg19402173 chr7:128379420 CALU 0.47 6.83 0.35 4.18e-11 Response to irinotecan and platinum-based chemotherapy in non-small-cell lung cancer; CRC cis rs1008375 0.966 rs11737844 chr4:17697421 A/C cg16339924 chr4:17578868 LAP3 0.49 6.63 0.34 1.39e-10 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs6484504 0.625 rs672396 chr11:31386165 A/G cg14844989 chr11:31128820 NA 0.35 6.18 0.32 1.94e-9 Red blood cell count; CRC cis rs8067545 0.516 rs11869258 chr17:20206898 G/A cg13482628 chr17:19912719 NA -0.47 -7.52 -0.38 5.29e-13 Schizophrenia; CRC cis rs2243480 0.901 rs778693 chr7:65872345 T/G cg18252515 chr7:66147081 NA -1.3 -15.32 -0.65 2.37e-40 Diabetic kidney disease; CRC cis rs4474465 0.736 rs11237541 chr11:78261703 T/C cg27205649 chr11:78285834 NARS2 0.49 6.39 0.33 5.8e-10 Alzheimer's disease (survival time); CRC cis rs1983170 0.778 rs906241 chr1:92012154 G/T cg25838465 chr1:92012736 NA -0.47 -6.51 -0.34 2.83e-10 Eosinophil percentage of white cells; CRC cis rs950776 0.714 rs472054 chr15:78887994 A/G cg06917634 chr15:78832804 PSMA4 -0.51 -7.55 -0.38 4.4e-13 Sudden cardiac arrest; CRC trans rs4714291 0.802 rs1923465 chr6:39971376 A/T cg02267698 chr19:7991119 CTXN1 -0.51 -6.87 -0.35 3.15e-11 Strep throat; CRC cis rs6502050 0.799 rs11491185 chr17:80151101 C/T cg02741985 chr17:80059408 CCDC57 0.44 7.18 0.37 4.6e-12 Life satisfaction; CRC cis rs11203032 0.831 rs11203019 chr10:90952774 A/T cg16672925 chr10:90967113 CH25H 0.45 5.74 0.3 2.17e-8 Heart failure; CRC cis rs4713118 0.513 rs156738 chr6:28014025 G/C cg15786705 chr6:28176104 NA 0.58 8.22 0.41 4.65e-15 Parkinson's disease; CRC cis rs11122272 0.735 rs2486728 chr1:231535883 T/G cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.57 -8.6 -0.43 3.21e-16 Hemoglobin concentration; CRC cis rs4631830 0.869 rs4131357 chr10:51537292 C/A cg16070123 chr10:51489643 NA -0.34 -5.85 -0.31 1.2e-8 Prostate-specific antigen levels; CRC cis rs9875589 0.509 rs7653289 chr3:13986333 C/T cg14375111 chr3:14165186 TMEM43;CHCHD4 0.41 6.25 0.33 1.28e-9 Ovarian reserve; CRC trans rs61931739 0.500 rs12371415 chr12:34521362 C/T cg26384229 chr12:38710491 ALG10B 0.67 8.67 0.43 1.98e-16 Morning vs. evening chronotype; CRC cis rs72945132 0.882 rs7122057 chr11:70201430 T/C cg00319359 chr11:70116639 PPFIA1 0.58 6.51 0.34 2.85e-10 Coronary artery disease; CRC cis rs7412746 0.611 rs752376 chr1:150941381 C/T cg10589385 chr1:150898437 SETDB1 0.27 5.87 0.31 1.07e-8 Melanoma; CRC trans rs916888 0.821 rs199512 chr17:44857352 T/C cg22433210 chr17:43662623 NA -0.82 -9.07 -0.45 1.11e-17 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs12545109 0.837 rs4738500 chr8:57356193 G/A cg09654669 chr8:57350985 NA -0.43 -5.81 -0.31 1.44e-8 Obesity-related traits; CRC trans rs1814175 0.817 rs11040700 chr11:50023832 C/T cg03929089 chr4:120376271 NA -0.96 -19.23 -0.73 9.03e-56 Height; CRC cis rs1799949 1.000 rs9646417 chr17:41424253 G/A cg23758822 chr17:41437982 NA 0.82 13.67 0.6 5.17e-34 Menopause (age at onset); CRC cis rs7937682 0.960 rs480293 chr11:111469132 A/C cg09085632 chr11:111637200 PPP2R1B -0.94 -17.74 -0.7 7.01e-50 Primary sclerosing cholangitis; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg25371950 chr2:242786524 NA 0.36 6.19 0.32 1.82e-9 Liver disease severity in Alagille syndrome; CRC cis rs9329289 0.851 rs61835719 chr10:2543390 A/G cg15501526 chr10:2543763 NA 0.76 15.88 0.66 1.53e-42 Age-related hearing impairment; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg05815685 chr19:36036576 TMEM147 0.36 6.0 0.31 5.34e-9 Liver disease severity in Alagille syndrome; CRC cis rs1005277 0.602 rs1831315 chr10:38473353 T/C cg17219203 chr10:38645113 HSD17B7P2 -0.41 -5.74 -0.3 2.12e-8 Extrinsic epigenetic age acceleration; CRC cis rs2732480 0.500 rs7966829 chr12:48615603 G/T cg24011408 chr12:48396354 COL2A1 0.4 5.71 0.3 2.47e-8 Hemoglobin concentration;Red blood cell count;Hematocrit; CRC cis rs477895 0.653 rs34089806 chr11:63887987 C/T cg23719950 chr11:63933701 MACROD1 -0.65 -8.24 -0.41 4.18e-15 Mean platelet volume; CRC cis rs3849570 0.533 rs6809792 chr3:81990084 C/T cg07356753 chr3:81810745 GBE1 -0.48 -6.4 -0.33 5.35e-10 Waist circumference;Body mass index; CRC cis rs4862750 0.957 rs6858853 chr4:187903412 A/C cg07414643 chr4:187882934 NA -0.36 -6.12 -0.32 2.6e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs1448094 0.511 rs58742237 chr12:86166444 C/T cg00310523 chr12:86230176 RASSF9 0.38 6.05 0.32 3.86e-9 Major depressive disorder; CRC cis rs7044106 0.718 rs1960421 chr9:123394894 C/G cg09586646 chr9:123605570 PSMD5;LOC253039 0.62 8.77 0.44 9.87e-17 Hip circumference adjusted for BMI; CRC cis rs1448094 0.533 rs7307617 chr12:86151317 T/C cg06740227 chr12:86229804 RASSF9 -0.38 -5.85 -0.31 1.17e-8 Major depressive disorder; CRC cis rs7072216 0.691 rs7910973 chr10:100166732 G/A cg26618903 chr10:100175079 PYROXD2 -0.55 -9.26 -0.45 2.73e-18 Metabolite levels; CRC cis rs10751667 0.621 rs10794353 chr11:948740 A/G cg06064525 chr11:970664 AP2A2 -0.33 -6.76 -0.35 6.29e-11 Alzheimer's disease (late onset); CRC cis rs6598955 0.543 rs12125620 chr1:26552238 G/A cg04990556 chr1:26633338 UBXN11 0.88 10.68 0.51 4.85e-23 Obesity-related traits; CRC cis rs7618915 0.547 rs2878726 chr3:52748271 C/G cg10802521 chr3:52805072 NEK4 -0.57 -8.77 -0.44 1.01e-16 Bipolar disorder; CRC cis rs58688157 0.705 rs12803132 chr11:586696 A/G cg03909863 chr11:638404 DRD4 -0.51 -6.6 -0.34 1.62e-10 Systemic lupus erythematosus; CRC cis rs6831352 0.918 rs7694646 chr4:100059732 T/A cg13256891 chr4:100009986 ADH5 -0.66 -8.98 -0.44 2.17e-17 Alcohol dependence; CRC cis rs10504229 0.683 rs16921831 chr8:58111142 G/A cg22535103 chr8:58192502 C8orf71 -0.7 -9.2 -0.45 4.33e-18 Developmental language disorder (linguistic errors); CRC cis rs55794721 0.509 rs4649085 chr1:25778832 G/A cg02931644 chr1:25747376 RHCE 0.32 5.68 0.3 2.94e-8 Plateletcrit;Mean corpuscular volume; CRC cis rs870825 0.616 rs28442259 chr4:185646962 T/G cg04058563 chr4:185651563 MLF1IP 0.72 9.3 0.46 2.04e-18 Blood protein levels; CRC cis rs4780401 0.933 rs4780396 chr16:11816671 G/A cg01061890 chr16:11836724 TXNDC11 -0.41 -5.61 -0.3 4.32e-8 Rheumatoid arthritis; CRC cis rs6570726 0.846 rs409553 chr6:145886963 C/T cg23711669 chr6:146136114 FBXO30 0.67 11.33 0.53 2.35e-25 Lobe attachment (rater-scored or self-reported); CRC cis rs7615952 0.673 rs35001498 chr3:125628644 A/G cg05084668 chr3:125655381 ALG1L -0.82 -9.99 -0.48 1.04e-20 Blood pressure (smoking interaction); CRC cis rs7208859 0.623 rs7503335 chr17:29073962 G/A cg13385521 chr17:29058706 SUZ12P 0.71 8.1 0.41 1.05e-14 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs7666738 0.822 rs6815312 chr4:99058220 T/C cg17366294 chr4:99064904 C4orf37 0.45 7.71 0.39 1.51e-13 Colonoscopy-negative controls vs population controls; CRC cis rs10256972 0.616 rs6957733 chr7:1106327 T/G cg22907277 chr7:1156413 C7orf50 0.42 6.25 0.33 1.28e-9 Longevity;Endometriosis; CRC cis rs4481887 0.893 rs28579823 chr1:248506881 C/T cg13385794 chr1:248469461 NA 0.35 6.39 0.33 5.79e-10 Common traits (Other); CRC cis rs7727544 0.507 rs9791170 chr5:131569627 A/G cg22638593 chr5:131593259 PDLIM4 0.47 8.57 0.43 4.13e-16 Blood metabolite levels; CRC cis rs853679 0.517 rs11552219 chr6:28126834 C/T cg02631126 chr6:28058918 ZSCAN12L1 0.29 5.91 0.31 8.38e-9 Depression; CRC cis rs17253792 0.732 rs10146604 chr14:56045770 C/G cg01858014 chr14:56050164 KTN1 -0.87 -7.54 -0.38 4.73e-13 Putamen volume; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg19590290 chr4:104119639 CENPE 0.4 6.04 0.32 4.25e-9 Response to antipsychotic treatment; CRC cis rs3857536 0.740 rs9360191 chr6:66942454 A/T cg07460842 chr6:66804631 NA -0.43 -5.78 -0.3 1.72e-8 Blood trace element (Cu levels); CRC cis rs10464366 0.912 rs2030960 chr7:39106010 G/A cg15212455 chr7:39170539 POU6F2 0.45 5.69 0.3 2.82e-8 IgG glycosylation; CRC cis rs1448094 0.549 rs12308898 chr12:86233678 G/A cg02569458 chr12:86230093 RASSF9 0.46 7.72 0.39 1.41e-13 Major depressive disorder; CRC cis rs17331151 0.505 rs35225119 chr3:52623465 A/T cg07884673 chr3:53033167 SFMBT1 0.76 6.04 0.32 4.25e-9 Immune reponse to smallpox (secreted IL-2); CRC cis rs11864453 0.826 rs12448315 chr16:72147242 G/T cg01557791 chr16:72042693 DHODH -0.46 -6.37 -0.33 6.41e-10 Fibrinogen levels; CRC cis rs8062405 1.000 rs62037371 chr16:28890131 C/A cg16576597 chr16:28551801 NUPR1 0.48 6.82 0.35 4.39e-11 Cognitive ability (multi-trait analysis);Cognitive ability; CRC cis rs731174 0.959 rs12747993 chr1:38190852 T/C cg06917450 chr1:38156652 C1orf109 -0.48 -6.87 -0.35 3.13e-11 Prostate cancer (SNP x SNP interaction); CRC cis rs372883 0.648 rs1153292 chr21:30689195 G/T cg24692254 chr21:30365293 RNF160 -0.6 -9.08 -0.45 1e-17 Pancreatic cancer; CRC cis rs10486722 0.606 rs2190338 chr7:41787240 A/G cg22138096 chr7:41772439 LOC285954 0.45 5.77 0.3 1.87e-8 Pit-and-Fissure caries; CRC trans rs61931739 0.534 rs12831685 chr12:34038392 C/T cg26384229 chr12:38710491 ALG10B 0.5 6.81 0.35 4.74e-11 Morning vs. evening chronotype; CRC cis rs2032447 0.672 rs9379811 chr6:25955197 G/C cg26028573 chr6:26043587 HIST1H2BB 0.42 6.26 0.33 1.19e-9 Intelligence (multi-trait analysis); CRC cis rs10504229 1.000 rs55787104 chr8:58178519 C/T cg05313129 chr8:58192883 C8orf71 -0.46 -6.95 -0.36 1.95e-11 Developmental language disorder (linguistic errors); CRC cis rs6519955 0.866 rs9626920 chr22:46428993 A/G cg05468064 chr22:46423449 NA -0.46 -9.48 -0.46 5.43e-19 Dupuytren's disease; CRC trans rs7267979 1.000 rs2500446 chr20:25339664 C/T cg17903999 chr18:56338584 MALT1 0.43 7.01 0.36 1.39e-11 Liver enzyme levels (alkaline phosphatase); CRC cis rs10256972 0.567 rs7782651 chr7:1159895 T/G cg23708337 chr7:1209742 NA 0.45 6.65 0.34 1.22e-10 Longevity;Endometriosis; CRC cis rs832540 0.931 rs33318 chr5:56208414 G/T cg24531977 chr5:56204891 C5orf35 -0.49 -7.51 -0.38 5.65e-13 Coronary artery disease; CRC cis rs9911578 1.000 rs1631237 chr17:56734695 A/G cg05425664 chr17:57184151 TRIM37 -0.5 -7.94 -0.4 3.16e-14 Intelligence (multi-trait analysis); CRC cis rs8072100 0.790 rs6505048 chr17:45674998 G/A cg25173405 chr17:45401733 C17orf57 0.4 5.99 0.31 5.51e-9 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs9303401 0.614 rs34550282 chr17:57092788 G/A cg02118635 chr17:56770003 RAD51C;TEX14 0.69 8.77 0.44 9.61e-17 Cognitive test performance; CRC cis rs8180040 0.627 rs9821119 chr3:47198437 C/G cg10298567 chr3:47292165 KIF9 -0.4 -6.25 -0.33 1.3e-9 Colorectal cancer; CRC cis rs17021463 0.555 rs7693950 chr4:95324901 A/T cg11021082 chr4:95130006 SMARCAD1 0.39 5.64 0.3 3.6e-8 Testicular germ cell tumor; CRC trans rs7267979 1.000 rs2258884 chr20:25279539 C/T cg17903999 chr18:56338584 MALT1 -0.42 -6.99 -0.36 1.52e-11 Liver enzyme levels (alkaline phosphatase); CRC cis rs9916302 0.706 rs7503377 chr17:37708841 A/G cg00129232 chr17:37814104 STARD3 -0.56 -6.85 -0.35 3.75e-11 Glomerular filtration rate (creatinine); CRC cis rs6089584 0.816 rs6061410 chr20:60625329 A/G cg13770153 chr20:60521292 NA -0.61 -9.28 -0.46 2.37e-18 Body mass index; CRC cis rs6951245 0.935 rs79067319 chr7:1065548 C/T cg24642844 chr7:1081250 C7orf50 -0.78 -9.3 -0.46 2.03e-18 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs1153858 1.000 rs4625670 chr15:45652926 C/T cg14582100 chr15:45693742 SPATA5L1 0.29 6.15 0.32 2.27e-9 Homoarginine levels; CRC cis rs34779708 0.931 rs12240347 chr10:35359475 A/G cg03585969 chr10:35415529 CREM 0.6 8.13 0.41 8.81e-15 Inflammatory bowel disease;Crohn's disease; CRC cis rs6952808 0.600 rs2895202 chr7:2131829 T/C cg22963979 chr7:1858916 MAD1L1 -0.44 -6.26 -0.33 1.22e-9 Bipolar disorder and schizophrenia; CRC cis rs12594515 1.000 rs8026221 chr15:45987910 G/T cg06207120 chr15:45996521 NA 0.32 7.75 0.39 1.14e-13 Waist circumference;Weight; CRC cis rs7809950 1.000 rs2520260 chr7:107172794 A/G cg23024343 chr7:107201750 COG5 -0.6 -8.66 -0.43 2.11e-16 Coronary artery disease; CRC cis rs1401999 1.000 rs869417 chr3:183689138 T/C cg05044414 chr3:183734942 ABCC5 0.47 8.11 0.41 1.03e-14 Anterior chamber depth; CRC cis rs775227 0.574 rs13086266 chr3:113083535 T/A cg18753928 chr3:113234510 CCDC52 -0.57 -6.64 -0.34 1.26e-10 Dental caries; CRC cis rs6901250 1.000 rs993394 chr6:117117143 G/A cg12892004 chr6:117198278 RFX6 0.44 6.7 0.35 8.94e-11 C-reactive protein levels; CRC cis rs28386778 0.897 rs1062787 chr17:61896004 T/C cg23090583 chr17:61904693 PSMC5;FTSJ3 1.05 20.27 0.75 7.25e-60 Prudent dietary pattern; CRC cis rs9329289 0.510 rs1155447 chr10:2553240 C/T cg15501526 chr10:2543763 NA 0.48 9.02 0.45 1.62e-17 Age-related hearing impairment; CRC cis rs853679 0.506 rs1150693 chr6:28174590 T/C cg12273811 chr6:28175739 NA 0.75 10.54 0.5 1.48e-22 Depression; CRC cis rs9487051 0.872 rs9386794 chr6:109611521 A/C cg12927641 chr6:109611667 NA -0.38 -6.95 -0.36 1.91e-11 Reticulocyte fraction of red cells; CRC cis rs9434723 0.841 rs12083129 chr1:9311323 G/A cg04199779 chr1:9294473 H6PD 0.51 5.72 0.3 2.45e-8 Height; CRC cis rs875971 0.895 rs1974769 chr7:65950614 G/A cg00343986 chr7:65444356 GUSB 0.44 6.39 0.33 5.77e-10 Aortic root size; CRC cis rs6951245 1.000 rs74347384 chr7:1072440 G/A cg22907277 chr7:1156413 C7orf50 0.71 7.39 0.38 1.26e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs875971 0.862 rs3893216 chr7:65790707 G/C cg11764359 chr7:65958608 NA -0.58 -8.57 -0.43 4.21e-16 Aortic root size; CRC cis rs7264396 0.790 rs3746410 chr20:34190870 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.48 -8.03 -0.4 1.71e-14 Total cholesterol levels; CRC cis rs10540 0.730 rs61877766 chr11:512973 T/G cg03352830 chr11:487213 PTDSS2 0.65 7.42 0.38 1.03e-12 Body mass index; CRC cis rs736408 0.812 rs2071508 chr3:52826846 A/G cg10802521 chr3:52805072 NEK4 0.46 6.29 0.33 9.92e-10 Bipolar disorder; CRC trans rs7395662 0.591 rs12807777 chr11:48593754 A/T cg03929089 chr4:120376271 NA -0.47 -6.62 -0.34 1.44e-10 HDL cholesterol; CRC cis rs9733 0.818 rs12403609 chr1:150676485 T/C cg18016565 chr1:150552671 MCL1 -0.43 -6.3 -0.33 9.32e-10 Tonsillectomy; CRC cis rs1878931 0.559 rs11643501 chr16:3392752 T/C cg26668626 chr16:3451006 ZNF174;ZNF434 0.52 7.34 0.37 1.72e-12 Body mass index (adult); CRC cis rs7927771 0.965 rs1064608 chr11:47640429 G/C cg05585544 chr11:47624801 NA -0.62 -11.41 -0.53 1.22e-25 Subjective well-being; CRC cis rs8060686 0.641 rs111227007 chr16:68093138 T/A cg08314208 chr16:67682810 RLTPR -0.58 -6.36 -0.33 6.74e-10 HDL cholesterol;Metabolic syndrome; CRC cis rs644799 1.000 rs473148 chr11:95628606 A/G cg25622487 chr11:95524042 FAM76B;CEP57 0.74 11.3 0.53 3.07e-25 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs7726839 0.794 rs6883536 chr5:599274 G/A cg16447950 chr5:562315 NA -0.54 -8.04 -0.41 1.62e-14 Obesity-related traits; CRC cis rs1670533 1.000 rs629261 chr4:1086763 A/C cg27284194 chr4:1044797 NA 0.5 6.33 0.33 7.9e-10 Recombination rate (females); CRC cis rs798554 0.679 rs2527681 chr7:2892384 A/T cg19346786 chr7:2764209 NA -0.39 -6.79 -0.35 5.33e-11 Height; CRC cis rs10504229 0.775 rs72650876 chr8:58161638 G/A cg22535103 chr8:58192502 C8orf71 -0.71 -8.45 -0.42 9.58e-16 Developmental language disorder (linguistic errors); CRC cis rs4664308 0.905 rs62177860 chr2:160960571 C/T cg03641300 chr2:160917029 PLA2R1 -0.74 -12.27 -0.56 9.46e-29 Idiopathic membranous nephropathy; CRC cis rs6951245 1.000 rs74369356 chr7:1071711 T/C cg24642844 chr7:1081250 C7orf50 -0.78 -9.35 -0.46 1.42e-18 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC trans rs1436351 0.683 rs7616848 chr3:104620951 G/T cg09862801 chr2:45396991 NA 0.47 5.99 0.31 5.57e-9 Body mass index; CRC cis rs1799949 0.894 rs71367985 chr17:41374463 G/A cg19454999 chr17:41278357 BRCA1;NBR2 0.41 6.23 0.32 1.41e-9 Menopause (age at onset); CRC cis rs2055729 0.507 rs814424 chr8:9942924 C/T cg21625330 chr8:9911636 MSRA 0.55 6.05 0.32 3.92e-9 Multiple myeloma (hyperdiploidy); CRC cis rs7811142 1.000 rs68116612 chr7:100006493 G/A cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.02 14.67 0.63 7.66e-38 Platelet count; CRC cis rs13118159 0.509 rs4974556 chr4:1358141 G/C cg05025164 chr4:1340916 KIAA1530 0.6 8.51 0.42 6.3e-16 Longevity; CRC cis rs9926296 0.568 rs886950 chr16:89836872 T/C cg03388025 chr16:89894329 SPIRE2 0.43 8.68 0.43 1.82e-16 Vitiligo; CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg01591470 chr14:39736043 CTAGE5 0.37 6.05 0.32 3.86e-9 Obesity-related traits; CRC cis rs9916302 0.904 rs2338798 chr17:37547269 T/C cg00129232 chr17:37814104 STARD3 0.54 8.03 0.4 1.73e-14 Glomerular filtration rate (creatinine); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg02387613 chr3:133380479 TOPBP1 0.45 6.52 0.34 2.6200000000000003e-10 Intelligence (multi-trait analysis); CRC cis rs6933660 0.744 rs3800279 chr6:151766162 T/C cg10883421 chr6:151773342 RMND1;C6orf211 0.49 7.37 0.38 1.39e-12 Menarche (age at onset); CRC cis rs6088590 1.000 rs6088595 chr20:33358499 T/A cg24642439 chr20:33292090 TP53INP2 0.61 9.9 0.48 2.08e-20 Coronary artery disease; CRC cis rs1707322 0.721 rs12043945 chr1:46106922 T/A cg06784218 chr1:46089804 CCDC17 0.66 12.54 0.57 9.25e-30 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs13082711 0.520 rs2724494 chr3:27563920 C/A cg02860705 chr3:27208620 NA 0.42 6.17 0.32 2.05e-9 Systolic blood pressure;Diastolic blood pressure;Blood pressure; CRC cis rs7703744 0.634 rs3797340 chr5:118691737 C/G cg23985447 chr5:118691066 TNFAIP8 0.42 6.02 0.31 4.71e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs9910055 0.718 rs2526022 chr17:42213216 C/T cg19774624 chr17:42201019 HDAC5 -0.66 -9.77 -0.47 5.91e-20 Total body bone mineral density; CRC cis rs2576037 0.623 rs2576040 chr18:44582027 A/G cg07416455 chr18:44543612 TCEB3CL;KATNAL2 0.59 9.22 0.45 3.56e-18 Personality dimensions; CRC cis rs13118159 0.509 rs10023473 chr4:1375285 C/T cg20887711 chr4:1340912 KIAA1530 0.66 9.54 0.47 3.46e-19 Longevity; CRC cis rs34888975 1 rs34888975 chr16:1695896 T/TA cg09065629 chr16:1709722 CRAMP1L 0.9 9.15 0.45 5.99e-18 Snoring; CRC cis rs1008375 0.966 rs28750296 chr4:17685826 A/T cg16339924 chr4:17578868 LAP3 0.53 7.11 0.37 7.11e-12 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs853679 0.666 rs200956 chr6:27839746 A/G cg15786705 chr6:28176104 NA 0.52 6.06 0.32 3.69e-9 Depression; CRC cis rs11098499 1.000 rs10029750 chr4:120172543 A/G cg24375607 chr4:120327624 NA 0.44 6.82 0.35 4.4e-11 Corneal astigmatism; CRC cis rs7917772 0.636 rs7088981 chr10:104520423 T/C cg11453585 chr10:104263688 ACTR1A;SUFU -0.69 -10.29 -0.49 1.06e-21 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC cis rs8060686 0.641 rs7188085 chr16:68113873 A/G cg08314208 chr16:67682810 RLTPR -0.49 -5.97 -0.31 5.98e-9 HDL cholesterol;Metabolic syndrome; CRC cis rs1941023 0.606 rs3825020 chr11:60184191 G/A cg08716584 chr11:60157161 MS4A7 -0.48 -7.88 -0.4 4.99e-14 Congenital heart disease (maternal effect); CRC trans rs7267979 0.844 rs2424703 chr20:25270124 G/A cg17903999 chr18:56338584 MALT1 -0.42 -6.83 -0.35 4.14e-11 Liver enzyme levels (alkaline phosphatase); CRC cis rs7799006 0.757 rs2398668 chr7:2298227 A/G cg08027265 chr7:2291960 NA 0.46 7.83 0.4 6.56e-14 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs6456156 0.586 rs1358883 chr6:167467433 C/G cg07741184 chr6:167504864 NA -0.38 -6.69 -0.35 9.86e-11 Primary biliary cholangitis; CRC cis rs7772486 0.782 rs7747576 chr6:146277827 C/T cg13319975 chr6:146136371 FBXO30 0.41 6.1 0.32 2.98e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs9354308 0.901 rs2814121 chr6:66566915 G/C cg07460842 chr6:66804631 NA 0.47 5.92 0.31 8.03e-9 Metabolite levels; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg04849129 chr2:191513396 NAB1 0.42 6.02 0.31 4.62e-9 Intelligence (multi-trait analysis); CRC cis rs514406 0.893 rs476108 chr1:53317351 C/T cg24675658 chr1:53192096 ZYG11B -0.56 -8.49 -0.42 7.39e-16 Monocyte count; CRC trans rs2228479 0.850 rs11649162 chr16:89807131 C/A cg21302420 chr1:112162376 RAP1A 0.72 5.96 0.31 6.38e-9 Skin colour saturation; CRC cis rs4665809 0.590 rs4665837 chr2:26434022 C/A cg26119090 chr2:26468346 HADHA;HADHB -1.06 -15.14 -0.64 1.2e-39 Gut microbiome composition (summer); CRC cis rs1003719 0.788 rs2835575 chr21:38455936 A/G cg10648535 chr21:38446584 PIGP;TTC3 0.52 7.31 0.37 2.01e-12 Eye color traits; CRC cis rs9287719 0.967 rs6759714 chr2:10747207 A/G cg00105475 chr2:10696890 NA 0.45 7.15 0.37 5.48e-12 Prostate cancer; CRC cis rs11690935 0.959 rs10206062 chr2:172577276 A/T cg13550731 chr2:172543902 DYNC1I2 -1.1 -18.72 -0.72 9.47e-54 Schizophrenia; CRC cis rs780096 0.526 rs3845686 chr2:27655447 T/G cg12000995 chr2:27665139 KRTCAP3 -0.33 -6.64 -0.34 1.3100000000000001e-10 Total body bone mineral density; CRC cis rs4563143 0.675 rs55976444 chr19:29265214 G/C cg03161606 chr19:29218774 NA 0.52 6.52 0.34 2.68e-10 Methadone dose in opioid dependence; CRC cis rs6502050 0.871 rs7226049 chr17:80071049 A/G cg22110888 chr17:80059540 CCDC57 -0.41 -6.28 -0.33 1.05e-9 Life satisfaction; CRC cis rs6952808 0.573 rs12668848 chr7:2020995 G/A cg21782813 chr7:2030301 MAD1L1 0.48 8.87 0.44 4.6e-17 Bipolar disorder and schizophrenia; CRC cis rs4665809 1.000 rs6749855 chr2:26255263 A/G cg26119090 chr2:26468346 HADHA;HADHB -0.62 -7.87 -0.4 5.21e-14 Gut microbiome composition (summer); CRC cis rs2976388 0.647 rs2244163 chr8:143784500 T/G cg05569086 chr8:143859399 LYNX1 0.38 6.62 0.34 1.42e-10 Urinary tract infection frequency; CRC cis rs875971 1.000 rs2077593 chr7:65892530 A/G cg18912574 chr7:65842487 NCRNA00174 0.36 6.18 0.32 1.85e-9 Aortic root size; CRC cis rs2749592 0.550 rs12255038 chr10:37869332 T/C cg25517755 chr10:38738941 LOC399744 0.41 5.98 0.31 5.66e-9 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs727505 0.754 rs56056794 chr7:124783027 C/T cg23710748 chr7:124431027 NA -0.67 -11.44 -0.53 9.61e-26 Lewy body disease; CRC cis rs7918232 0.941 rs788210 chr10:27476948 T/C cg14240646 chr10:27532245 ACBD5 0.86 9.57 0.47 2.6e-19 Breast cancer; CRC cis rs4803468 1.000 rs2241709 chr19:41912250 C/T cg09537434 chr19:41945824 ATP5SL -0.92 -18.27 -0.71 5.69e-52 Height; CRC cis rs7833986 0.501 rs72653990 chr8:57037115 G/A cg23139584 chr8:56987506 RPS20;SNORD54 0.92 11.98 0.55 1.1e-27 Height; CRC cis rs7193541 0.691 rs3851728 chr16:74480660 C/T cg01733217 chr16:74700730 RFWD3 0.73 12.65 0.57 3.78e-30 Multiple myeloma; CRC cis rs6479527 0.875 rs914295 chr9:96816843 C/A cg14459158 chr9:96720562 NA 0.38 6.79 0.35 5.13e-11 Esophageal adenocarcinoma; CRC trans rs12663356 0.528 rs9350359 chr6:21462624 C/T cg16239906 chr20:35724590 RBL1 0.44 6.98 0.36 1.68e-11 Crohn's disease; CRC cis rs9409565 0.586 rs58057339 chr9:97117788 T/C cg04523069 chr9:97136363 HIATL1 -0.47 -6.35 -0.33 7.32e-10 Colorectal cancer (alcohol consumption interaction); CRC cis rs6684514 1.000 rs12023438 chr1:156254358 A/G cg16558208 chr1:156270281 VHLL 0.58 9.04 0.45 1.34e-17 Mean corpuscular hemoglobin concentration;Glycated hemoglobin levels; CRC cis rs7927592 0.913 rs3824850 chr11:68341873 A/G cg01657329 chr11:68192670 LRP5 -0.47 -6.79 -0.35 5.16e-11 Total body bone mineral density; CRC cis rs7208859 0.623 rs73269923 chr17:29102571 C/T cg01831904 chr17:28903510 LRRC37B2 -0.66 -6.75 -0.35 6.59e-11 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs7107174 1.000 rs9651769 chr11:77996166 T/C cg02023728 chr11:77925099 USP35 0.54 8.2 0.41 5.59e-15 Testicular germ cell tumor; CRC cis rs10193935 0.792 rs6735571 chr2:42491951 C/T cg27598129 chr2:42591480 NA -0.49 -6.13 -0.32 2.58e-9 Colonoscopy-negative controls vs population controls; CRC cis rs9303401 0.580 rs12603808 chr17:56578508 T/G cg10487724 chr17:56770010 TEX14;RAD51C 0.79 8.99 0.44 1.96e-17 Cognitive test performance; CRC cis rs62064224 0.512 rs9912766 chr17:30712780 A/G cg21839984 chr17:30846986 MYO1D -0.33 -5.64 -0.3 3.68e-8 Schizophrenia; CRC cis rs9486719 0.857 rs13208321 chr6:96860354 C/T cg06623918 chr6:96969491 KIAA0776 -0.63 -8.19 -0.41 5.99e-15 Migraine;Coronary artery disease; CRC cis rs3772130 0.962 rs9841595 chr3:121483326 A/G cg20356878 chr3:121714668 ILDR1 0.51 7.9 0.4 4.1e-14 Cognitive performance; CRC cis rs9486719 0.843 rs3860229 chr6:97036559 T/C cg18709589 chr6:96969512 KIAA0776 -0.46 -5.93 -0.31 7.72e-9 Migraine;Coronary artery disease; CRC cis rs7487075 0.823 rs34472481 chr12:46836348 C/G cg22049899 chr12:47219821 SLC38A4 0.32 6.44 0.33 4.31e-10 Itch intensity from mosquito bite; CRC cis rs1552244 1.000 rs6772315 chr3:10113644 G/A cg02579736 chr3:10068473 FANCD2;CIDECP 1.02 13.66 0.6 5.95e-34 Alzheimer's disease; CRC cis rs897984 0.762 rs2054213 chr16:30971810 A/G cg02466173 chr16:30829666 NA 0.61 9.26 0.45 2.81e-18 Dementia with Lewy bodies; CRC cis rs853679 0.550 rs6901017 chr6:28152583 T/C cg15786705 chr6:28176104 NA 0.79 10.68 0.51 4.77e-23 Depression; CRC cis rs7666738 0.830 rs7696568 chr4:99005333 A/T cg05340658 chr4:99064831 C4orf37 0.61 9.54 0.47 3.44e-19 Colonoscopy-negative controls vs population controls; CRC cis rs919433 0.963 rs4850786 chr2:198178608 A/G cg10820045 chr2:198174542 NA 0.55 9.19 0.45 4.68e-18 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC cis rs9611565 0.659 rs12484694 chr22:41919330 A/G cg03806693 chr22:41940476 POLR3H -1.13 -15.23 -0.64 5.21e-40 Vitiligo; CRC cis rs7618501 1.000 rs7372730 chr3:49790682 C/G cg24308560 chr3:49941425 MST1R 0.45 7.06 0.36 9.95e-12 Intelligence (multi-trait analysis); CRC cis rs8077889 0.645 rs1230396 chr17:41843029 A/C cg26893861 chr17:41843967 DUSP3 -1.21 -26.44 -0.82 2.1e-83 Triglycerides; CRC cis rs1865760 1.000 rs2071297 chr6:25924513 C/G cg16482183 chr6:26056742 HIST1H1C -0.55 -7.91 -0.4 4e-14 Height; CRC cis rs9486715 0.867 rs9373829 chr6:96897201 A/C cg06623918 chr6:96969491 KIAA0776 -0.93 -16.57 -0.67 2.9e-45 Headache; CRC cis rs58649573 0.509 rs10739635 chr9:126792086 A/G cg14112217 chr9:126806003 NA 0.39 5.78 0.3 1.71e-8 Post-traumatic stress disorder; CRC cis rs875971 0.516 rs6945322 chr7:65336056 T/C cg18912574 chr7:65842487 NCRNA00174 0.33 5.66 0.3 3.37e-8 Aortic root size; CRC cis rs4728302 0.807 rs10226267 chr7:133601862 G/A cg10665199 chr7:133106180 EXOC4 0.38 5.78 0.3 1.76e-8 Intelligence;Intelligence (multi-trait analysis); CRC cis rs9311474 0.508 rs6786043 chr3:52604861 A/G cg18404041 chr3:52824283 ITIH1 -0.4 -8.45 -0.42 9.79e-16 Electroencephalogram traits; CRC cis rs28489187 0.706 rs12124170 chr1:85811182 A/G cg17737388 chr1:85724454 C1orf52 0.37 5.63 0.3 3.91e-8 Asymmetrical dimethylarginine levels;Serum dimethylarginine levels (asymmetric/symetric ratio); CRC cis rs10504229 0.689 rs17801390 chr8:58054768 T/C cg02725872 chr8:58115012 NA -0.56 -7.62 -0.39 2.74e-13 Developmental language disorder (linguistic errors); CRC cis rs4713118 0.911 rs2394000 chr6:27686991 A/G cg25164649 chr6:28176230 NA 0.57 7.55 0.38 4.3e-13 Parkinson's disease; CRC cis rs7737355 1.000 rs2158428 chr5:130751481 T/A cg06307176 chr5:131281290 NA -0.4 -6.1 -0.32 2.9e-9 Life satisfaction; CRC cis rs589448 0.902 rs315113 chr12:69786543 G/T cg22834771 chr12:69754056 YEATS4 0.54 8.4 0.42 1.36e-15 Cerebrospinal fluid biomarker levels; CRC cis rs9325144 0.555 rs4882284 chr12:38710459 C/T cg26384229 chr12:38710491 ALG10B -0.55 -8.22 -0.41 4.67e-15 Morning vs. evening chronotype; CRC cis rs9309473 1.000 rs56672945 chr2:73622663 C/T cg20560298 chr2:73613845 ALMS1 -0.48 -6.14 -0.32 2.36e-9 Metabolite levels; CRC cis rs2228479 1.000 rs62052186 chr16:89969567 A/T cg12064134 chr16:90016061 DEF8 -0.69 -6.13 -0.32 2.54e-9 Skin colour saturation; CRC cis rs8177179 1.000 rs8177179 chr3:133463457 G/A cg24879335 chr3:133465180 TF 0.49 9.75 0.47 6.84e-20 Iron status biomarkers (transferrin levels); CRC trans rs1814175 0.645 rs28538913 chr11:50040718 C/T cg03929089 chr4:120376271 NA -0.89 -15.95 -0.66 7.68e-43 Height; CRC cis rs9322193 0.847 rs868375 chr6:150166041 T/A cg00933542 chr6:150070202 PCMT1 0.29 5.6 0.3 4.52e-8 Lung cancer; CRC cis rs2576037 0.526 rs10853547 chr18:44530548 A/C cg19077165 chr18:44547161 KATNAL2 -0.58 -9.31 -0.46 1.82e-18 Personality dimensions; CRC trans rs4965598 0.958 rs4965593 chr15:100758385 C/G cg05653646 chr5:139173162 NA -0.44 -6.02 -0.31 4.66e-9 Height; CRC cis rs7633770 0.786 rs6442012 chr3:46686346 A/G cg11219411 chr3:46661640 NA 0.54 8.27 0.42 3.24e-15 Coronary artery disease; CRC cis rs7552404 0.731 rs11161845 chr1:76367559 T/C cg03433033 chr1:76189801 ACADM 0.72 8.73 0.43 1.35e-16 Blood metabolite levels;Acylcarnitine levels; CRC cis rs1552244 1.000 rs7619340 chr3:10108178 C/T cg00166722 chr3:10149974 C3orf24 0.71 9.42 0.46 8.32e-19 Alzheimer's disease; CRC cis rs9467711 0.584 rs34244947 chr6:26761745 T/C cg16898833 chr6:26189333 HIST1H4D 1.05 7.54 0.38 4.49e-13 Autism spectrum disorder or schizophrenia; CRC cis rs10078 0.559 rs2672725 chr5:434981 G/C cg08916839 chr5:415575 AHRR 0.77 8.31 0.42 2.57e-15 Fat distribution (HIV); CRC cis rs9733 0.596 rs12077833 chr1:150674333 C/T cg10589385 chr1:150898437 SETDB1 0.3 6.23 0.32 1.44e-9 Tonsillectomy; CRC cis rs72772090 0.539 rs72773969 chr5:96145196 C/T cg17330273 chr5:96107758 CAST;ERAP1 -0.62 -6.04 -0.32 4.22e-9 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC trans rs208520 0.690 rs2797693 chr6:66868985 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.05 -14.8 -0.63 2.42e-38 Exhaled nitric oxide output; CRC cis rs1018836 0.923 rs7812970 chr8:91541229 G/A cg16814680 chr8:91681699 NA -0.74 -12.1 -0.55 4.09e-28 Ejection fraction in Tripanosoma cruzi seropositivity; CRC trans rs2797160 0.904 rs1739370 chr6:126011231 C/T cg05039488 chr6:79577232 IRAK1BP1 0.6 9.32 0.46 1.79e-18 Endometrial cancer; CRC cis rs4819052 0.851 rs2255766 chr21:46683777 C/T cg02159808 chr21:46707872 POFUT2;LOC642852 0.52 6.77 0.35 6.07e-11 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs4722166 1.000 rs4722166 chr7:22738762 G/T cg26061582 chr7:22766209 IL6 0.52 7.29 0.37 2.33e-12 Lung cancer; CRC cis rs4481887 0.676 rs946764 chr1:248522033 A/C cg26353448 chr1:248524236 OR2T4 -0.34 -6.93 -0.36 2.27e-11 Common traits (Other); CRC cis rs2932538 0.922 rs12137107 chr1:113127437 A/G cg22162597 chr1:113214053 CAPZA1 0.73 10.54 0.5 1.4e-22 Systolic blood pressure;Diastolic blood pressure;Hypertension;Blood pressure; CRC cis rs7666738 0.535 rs6850010 chr4:98971601 A/T cg05340658 chr4:99064831 C4orf37 0.61 9.3 0.46 2.07e-18 Colonoscopy-negative controls vs population controls; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg04603834 chr13:50571387 TRIM13;DLEU2 0.45 6.25 0.33 1.28e-9 Response to antipsychotic treatment; CRC cis rs35306767 0.855 rs12771179 chr10:872347 A/G cg26597838 chr10:835615 NA 1.25 15.13 0.64 1.26e-39 Eosinophil percentage of granulocytes; CRC cis rs1950626 0.750 rs34228453 chr14:101440321 A/C cg02351406 chr14:101447389 SNORD114-20;SNORD114-21 0.96 15.65 0.65 1.23e-41 Pelvic organ prolapse (moderate/severe); CRC cis rs11971779 0.680 rs2355783 chr7:139075879 C/T cg23387468 chr7:139079360 LUC7L2 0.41 7.04 0.36 1.14e-11 Diisocyanate-induced asthma; CRC cis rs216303 1.000 rs216298 chr12:6156477 C/T cg19878637 chr12:6148451 VWF -0.54 -6.14 -0.32 2.43e-9 Low vWF levels; CRC cis rs79976124 0.877 rs79507557 chr6:66640908 C/A cg07460842 chr6:66804631 NA 0.77 9.45 0.46 6.33e-19 Type 2 diabetes; CRC cis rs2880765 0.835 rs28874135 chr15:86031503 G/A cg17133734 chr15:86042851 AKAP13 0.43 6.73 0.35 7.69e-11 Coronary artery disease; CRC cis rs7107174 0.892 rs7115850 chr11:78045071 C/G cg02023728 chr11:77925099 USP35 0.48 8.57 0.43 3.97e-16 Testicular germ cell tumor; CRC cis rs10927875 0.631 rs28579893 chr1:16347534 A/G cg21385522 chr1:16154831 NA 0.6 7.56 0.38 4.03e-13 Dilated cardiomyopathy; CRC cis rs6964587 1.000 rs10263309 chr7:91645265 A/G cg17063962 chr7:91808500 NA 0.8 14.31 0.62 1.96e-36 Breast cancer; CRC cis rs7809950 0.953 rs3094383 chr7:107143164 G/A cg23024343 chr7:107201750 COG5 -0.61 -8.69 -0.43 1.77e-16 Coronary artery disease; CRC cis rs6570726 0.764 rs1912023 chr6:145824278 C/A cg05347473 chr6:146136440 FBXO30 0.4 6.23 0.32 1.45e-9 Lobe attachment (rater-scored or self-reported); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg17371350 chr17:655677 ELP2P;GEMIN4 0.42 7.08 0.36 8.54e-12 Liver disease severity in Alagille syndrome; CRC cis rs2354432 1.000 rs2354432 chr1:146693229 C/T cg25205988 chr1:146714368 CHD1L 1.16 12.98 0.58 2.18e-31 Mitochondrial DNA levels; CRC cis rs4713118 0.869 rs9461405 chr6:27719375 G/T cg08798685 chr6:27730294 NA -0.44 -6.47 -0.34 3.6e-10 Parkinson's disease; CRC cis rs2239547 0.657 rs2276817 chr3:52860936 C/T cg18404041 chr3:52824283 ITIH1 -0.41 -7.65 -0.39 2.25e-13 Schizophrenia; CRC cis rs1448094 0.511 rs61930587 chr12:86158793 T/C cg06740227 chr12:86229804 RASSF9 0.38 5.62 0.3 4.06e-8 Major depressive disorder; CRC cis rs6460942 0.591 rs80311633 chr7:12339690 G/C cg06484146 chr7:12443880 VWDE -0.62 -6.65 -0.34 1.2e-10 Coronary artery disease; CRC cis rs10504229 0.679 rs56040464 chr8:58131603 G/A cg21724239 chr8:58056113 NA 0.49 6.81 0.35 4.75e-11 Developmental language disorder (linguistic errors); CRC trans rs783540 0.967 rs1269134 chr15:83282628 T/C cg18393722 chr15:85113863 UBE2QP1 -0.38 -6.27 -0.33 1.13e-9 Schizophrenia; CRC cis rs7095944 0.614 rs61872084 chr10:126439062 C/T cg08799069 chr10:126477246 METTL10 -0.44 -6.84 -0.35 3.81e-11 Asthma; CRC cis rs798554 0.724 rs798498 chr7:2795882 T/G cg14895029 chr7:2775587 GNA12 -0.41 -6.31 -0.33 9.1e-10 Height; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg11768411 chr8:144329279 ZFP41 0.37 6.14 0.32 2.36e-9 Liver disease severity in Alagille syndrome; CRC cis rs6502050 0.871 rs11870632 chr17:80075406 T/C cg19223190 chr17:80058835 NA -0.41 -6.56 -0.34 2.05e-10 Life satisfaction; CRC cis rs2346177 0.605 rs7556828 chr2:46663172 A/G cg02822958 chr2:46747628 ATP6V1E2 -0.4 -6.14 -0.32 2.34e-9 HDL cholesterol; CRC cis rs711245 0.670 rs7560321 chr2:36822318 C/G cg10546459 chr2:36825355 FEZ2 -0.52 -7.35 -0.38 1.55e-12 Height; CRC cis rs7914558 0.966 rs12569617 chr10:104729996 T/C cg15744005 chr10:104629667 AS3MT -0.34 -7.34 -0.38 1.69e-12 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs611744 0.647 rs2298603 chr8:109271426 C/T cg21045802 chr8:109455806 TTC35 0.36 5.69 0.3 2.86e-8 Dupuytren's disease; CRC cis rs853679 0.517 rs9380062 chr6:28137569 G/A cg02631126 chr6:28058918 ZSCAN12L1 0.29 5.91 0.31 8.38e-9 Depression; CRC cis rs17767392 0.918 rs17767410 chr14:71771967 C/G cg13720639 chr14:72061746 SIPA1L1 -0.53 -6.81 -0.35 4.7e-11 Mitral valve prolapse; CRC cis rs4268898 0.722 rs7563958 chr2:24422381 C/A cg26838691 chr2:24397539 C2orf84 0.41 5.72 0.3 2.46e-8 Asthma; CRC cis rs753778 0.963 rs3739234 chr8:142229178 G/A cg23750338 chr8:142222470 SLC45A4 0.4 6.12 0.32 2.62e-9 Reticulocyte fraction of red cells;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; CRC cis rs992157 0.835 rs34353396 chr2:219153982 T/C cg04731861 chr2:219085781 ARPC2 0.34 6.99 0.36 1.57e-11 Colorectal cancer; CRC cis rs1997103 0.822 rs940878 chr7:55419663 A/G cg17469321 chr7:55412551 NA 0.71 10.54 0.5 1.47e-22 QRS interval (sulfonylurea treatment interaction); CRC cis rs6942756 1.000 rs6949950 chr7:128914818 G/A cg02491457 chr7:128862824 NA -0.76 -10.48 -0.5 2.24e-22 White matter hyperintensity burden; CRC cis rs4423214 1.000 rs2002063 chr11:71163476 T/C cg05163923 chr11:71159392 DHCR7 0.67 9.53 0.46 3.69e-19 Vitamin D levels; CRC cis rs916888 0.773 rs199451 chr17:44801784 G/A cg15921436 chr17:44337874 NA 0.78 8.39 0.42 1.42e-15 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs698833 0.852 rs698761 chr2:44547574 A/G cg04920474 chr2:44395004 PPM1B -0.41 -6.11 -0.32 2.79e-9 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; CRC trans rs7395662 1.000 rs7931984 chr11:48580835 T/A cg21153622 chr11:89784906 NA -0.44 -7.12 -0.37 6.86e-12 HDL cholesterol; CRC cis rs12155623 0.619 rs870397 chr8:49861225 C/T cg00325661 chr8:49890786 NA 0.36 6.5 0.34 3.03e-10 Sudden cardiac arrest; CRC cis rs6540556 0.682 rs667681 chr1:209914449 A/G cg05527609 chr1:210001259 C1orf107 0.57 6.42 0.33 4.72e-10 Red blood cell count; CRC cis rs62244186 0.715 rs11130032 chr3:44704083 G/A cg15687855 chr3:44754131 ZNF502 -0.35 -5.87 -0.31 1.07e-8 Depressive symptoms; CRC cis rs780096 0.526 rs780106 chr2:27681598 A/C cg12648201 chr2:27665141 KRTCAP3 -0.31 -6.28 -0.33 1.05e-9 Total body bone mineral density; CRC cis rs270601 0.913 rs273899 chr5:131695178 G/A cg12564285 chr5:131593104 PDLIM4 0.45 7.55 0.38 4.27e-13 Acylcarnitine levels; CRC cis rs3806843 1.000 rs4404730 chr5:140162610 G/A cg16607685 chr5:140181889 PCDHA2;PCDHA1;PCDHA3 -0.26 -6.17 -0.32 1.99e-9 Depressive symptoms (multi-trait analysis); CRC cis rs12701220 0.817 rs1058727 chr7:1087095 A/G cg26769984 chr7:1090371 C7orf50 0.59 8.92 0.44 3.42e-17 Bronchopulmonary dysplasia; CRC cis rs1799949 0.536 rs4793227 chr17:41412250 A/C cg23758822 chr17:41437982 NA 0.85 15.68 0.65 8.75e-42 Menopause (age at onset); CRC trans rs1455244 0.700 rs7229302 chr18:11508904 G/T cg09670790 chr13:76056027 TBC1D4 0.38 6.0 0.31 5.3e-9 Schizophrenia; CRC cis rs9660992 0.573 rs1172159 chr1:205207512 T/C cg00857998 chr1:205179979 DSTYK 0.43 5.7 0.3 2.69e-8 Mean corpuscular volume;Mean platelet volume; CRC cis rs13118159 0.872 rs4974604 chr4:1345798 T/C cg02018176 chr4:1364513 KIAA1530 0.37 6.17 0.32 2.03e-9 Longevity; CRC cis rs10751667 1.000 rs12798036 chr11:947585 T/C ch.11.42038R chr11:967971 AP2A2 0.68 11.5 0.54 6.01e-26 Alzheimer's disease (late onset); CRC trans rs11098499 0.615 rs28850368 chr4:120554313 G/A cg25214090 chr10:38739885 LOC399744 0.56 8.83 0.44 6.36e-17 Corneal astigmatism; CRC cis rs2456568 0.548 rs4753113 chr11:93660974 G/A cg26875233 chr11:93583750 C11orf90 -0.36 -6.91 -0.36 2.46e-11 Response to serotonin reuptake inhibitors in major depressive disorder; CRC cis rs6076065 0.723 rs8183442 chr20:23415563 C/T cg11657817 chr20:23433608 CST11 0.44 6.3 0.33 9.49e-10 Facial morphology (factor 15, philtrum width); CRC cis rs4321325 0.733 rs4284778 chr2:127946326 A/G cg11380483 chr2:127933992 NA 0.6 7.65 0.39 2.18e-13 Protein C levels; CRC cis rs55879323 1 rs55879323 chr1:152168740 C/T cg26879891 chr1:152191343 HRNR -0.31 -5.89 -0.31 9.46e-9 Inflammatory skin disease; CRC cis rs13256369 0.802 rs11249883 chr8:8561537 G/A cg06636001 chr8:8085503 FLJ10661 0.48 6.1 0.32 2.99e-9 Obesity-related traits; CRC cis rs12477438 0.798 rs6705583 chr2:99602625 T/C cg26064155 chr2:99771622 LIPT1;TSGA10 -0.81 -11.63 -0.54 2.05e-26 Chronic sinus infection; CRC cis rs7647973 1.000 rs3870339 chr3:49536863 T/A cg20833759 chr3:49053208 WDR6;DALRD3 0.55 8.33 0.42 2.22e-15 Menarche (age at onset); CRC cis rs17270561 0.636 rs1165157 chr6:25792250 A/G cg17691542 chr6:26056736 HIST1H1C 0.52 7.09 0.36 8.45e-12 Iron status biomarkers; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg16553574 chr7:64839175 ZNF92 0.44 6.73 0.35 7.34e-11 Liver disease severity in Alagille syndrome; CRC cis rs3126085 0.935 rs11204943 chr1:152203906 A/C cg09127314 chr1:152161683 NA 0.47 6.02 0.31 4.67e-9 Atopic dermatitis; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg25266327 chr19:16435660 KLF2 -0.44 -6.75 -0.35 6.56e-11 Myopia (pathological); CRC cis rs6461049 0.766 rs10256077 chr7:2171450 C/T cg14004847 chr7:1930337 MAD1L1 0.41 5.85 0.31 1.2e-8 Schizophrenia; CRC cis rs1878931 0.507 rs35214904 chr16:3410017 C/A cg26668626 chr16:3451006 ZNF174;ZNF434 -0.48 -5.63 -0.3 3.83e-8 Body mass index (adult); CRC cis rs748404 0.587 rs9920879 chr15:43639770 A/G cg02155558 chr15:43621948 ADAL;LCMT2 0.54 7.82 0.4 7.4e-14 Lung cancer; CRC cis rs7666738 0.791 rs2081621 chr4:98926753 C/A cg05340658 chr4:99064831 C4orf37 0.6 9.35 0.46 1.41e-18 Colonoscopy-negative controls vs population controls; CRC cis rs720844 0.684 rs7597133 chr2:149317833 G/A cg09247360 chr2:149335327 NA -0.56 -6.03 -0.32 4.49e-9 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs908922 0.676 rs491077 chr1:152519570 C/A cg09873164 chr1:152488093 CRCT1 0.37 6.29 0.33 1e-9 Hair morphology; CRC cis rs12971120 0.947 rs4891559 chr18:72170397 C/T cg26446133 chr18:72167187 CNDP2 -0.73 -15.53 -0.65 3.42e-41 Refractive error; CRC cis rs7927771 0.864 rs3781625 chr11:47443080 T/C cg18512352 chr11:47633146 NA -0.4 -7.77 -0.39 9.9e-14 Subjective well-being; CRC cis rs2842992 0.715 rs2277073 chr6:160182749 G/A cg16489826 chr6:160211363 TCP1;MRPL18 0.49 6.2 0.32 1.7e-9 Age-related macular degeneration (geographic atrophy); CRC cis rs10504229 0.906 rs7842482 chr8:58167720 A/T cg02725872 chr8:58115012 NA -0.44 -8.5 -0.42 6.94e-16 Developmental language disorder (linguistic errors); CRC cis rs76533333 0.646 rs12861423 chr13:113387084 C/A cg04656015 chr13:113407548 ATP11A 0.75 5.75 0.3 2.09e-8 Red cell distribution width; CRC cis rs1552172 0.887 rs12402867 chr1:145636226 G/A cg11743829 chr1:145714124 CD160 -0.4 -6.09 -0.32 3.23e-9 Breast cancer; CRC cis rs1499614 1.000 rs2707840 chr7:66158015 C/T cg12463550 chr7:65579703 CRCP 0.64 5.79 0.3 1.66e-8 Gout; CRC cis rs116095464 1.000 rs28416084 chr5:217640 G/A cg22496380 chr5:211416 CCDC127 -0.95 -9.42 -0.46 8.46e-19 Breast cancer; CRC cis rs11785400 0.762 rs1137522 chr8:143739020 A/C cg10596483 chr8:143751796 JRK 0.43 5.8 0.3 1.57e-8 Schizophrenia; CRC cis rs17253792 0.822 rs79483507 chr14:56164718 G/T cg01858014 chr14:56050164 KTN1 -0.92 -7.32 -0.37 1.89e-12 Putamen volume; CRC cis rs873946 0.586 rs57431984 chr10:134567697 C/T cg18305652 chr10:134549665 INPP5A 0.49 6.26 0.33 1.23e-9 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CRC cis rs4664293 0.605 rs2042774 chr2:160510007 G/T cg08347373 chr2:160653686 CD302 0.39 6.68 0.35 1.03e-10 Monocyte percentage of white cells; CRC cis rs2075371 0.829 rs10954442 chr7:134007587 A/G cg20476274 chr7:133979776 SLC35B4 -0.67 -11.07 -0.52 2.03e-24 Mean platelet volume; CRC cis rs1008375 1.000 rs6846238 chr4:17629939 A/G cg16339924 chr4:17578868 LAP3 0.53 7.16 0.37 5.38e-12 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs6088590 0.561 rs6059926 chr20:33164804 C/T cg08999081 chr20:33150536 PIGU 0.64 12.57 0.57 7.41e-30 Coronary artery disease; CRC cis rs2976388 0.609 rs2257796 chr8:143808667 T/C cg05569086 chr8:143859399 LYNX1 0.39 6.68 0.35 1.04e-10 Urinary tract infection frequency; CRC cis rs2228479 0.850 rs17233497 chr16:89815152 G/A cg19635926 chr16:89946313 TCF25 0.69 5.82 0.31 1.37e-8 Skin colour saturation; CRC cis rs1223397 0.938 rs34505804 chr6:13292514 G/A cg00460589 chr6:13274354 PHACTR1 0.5 6.0 0.31 5.11e-9 Blood pressure; CRC cis rs9368481 0.761 rs9357028 chr6:26967224 T/G cg10547057 chr6:26987810 LOC100270746;C6orf41 -0.41 -5.82 -0.31 1.39e-8 Autism spectrum disorder or schizophrenia; CRC cis rs1401999 1.000 rs9858774 chr3:183652736 G/A cg05044414 chr3:183734942 ABCC5 0.49 8.34 0.42 2.09e-15 Anterior chamber depth; CRC cis rs4713118 0.513 rs149962 chr6:28015918 G/A cg03623178 chr6:28175578 NA 0.77 11.27 0.53 4.05e-25 Parkinson's disease; CRC trans rs1814175 0.781 rs28681334 chr11:50051177 C/T cg03929089 chr4:120376271 NA -0.93 -17.98 -0.7 7.84e-51 Height; CRC trans rs703108 0.731 rs7898954 chr10:22323646 A/G cg11777890 chr11:119205047 RNF26 -0.5 -6.19 -0.32 1.76e-9 Monocyte percentage of white cells; CRC cis rs597539 0.652 rs660614 chr11:68659488 G/A cg06028808 chr11:68637592 NA 0.4 6.34 0.33 7.42e-10 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs6500602 0.727 rs4238849 chr16:4538114 G/A cg08645402 chr16:4508243 NA 0.63 11.36 0.53 1.82e-25 Schizophrenia; CRC cis rs4332037 0.539 rs11763750 chr7:2080114 G/A cg23378565 chr7:2036160 MAD1L1 -0.45 -6.37 -0.33 6.48e-10 Bipolar disorder; CRC cis rs13082711 0.522 rs594466 chr3:27362069 A/G cg02860705 chr3:27208620 NA -0.47 -7.09 -0.36 8.29e-12 Systolic blood pressure;Diastolic blood pressure;Blood pressure; CRC cis rs1555895 0.568 rs4097329 chr10:844839 T/C cg10556349 chr10:835070 NA -0.4 -7.68 -0.39 1.78e-13 Survival in rectal cancer; CRC trans rs9858542 0.953 rs9837341 chr3:49664767 A/G cg21582582 chr3:182698605 DCUN1D1 -0.53 -6.39 -0.33 5.65e-10 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs9435341 0.930 rs12408634 chr1:107579540 G/A cg11070056 chr1:107600091 PRMT6 0.4 5.7 0.3 2.66e-8 Facial morphology (factor 21, depth of nasal alae); CRC cis rs977987 0.832 rs37597 chr16:75500275 T/G cg03315344 chr16:75512273 CHST6 -0.61 -10.1 -0.49 4.42e-21 Dupuytren's disease; CRC cis rs7089973 0.872 rs41284358 chr10:116622339 A/G cg23260525 chr10:116636907 FAM160B1 0.31 6.75 0.35 6.66e-11 Bipolar disorder or attention deficit hyperactivity disorder; CRC cis rs950169 0.920 rs17300048 chr15:84749477 C/T cg17507749 chr15:85114479 UBE2QP1 0.77 11.92 0.55 1.78e-27 Schizophrenia; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg23065101 chr7:100964734 RABL5 0.43 6.61 0.34 1.51e-10 Liver disease severity in Alagille syndrome; CRC cis rs7113874 0.569 rs4929942 chr11:8625096 A/G cg17679104 chr11:8615758 STK33 0.37 6.33 0.33 8.02e-10 Body mass index in physically active individuals;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs9462027 0.628 rs66506671 chr6:34777149 T/A cg07306190 chr6:34760872 UHRF1BP1 -0.34 -5.93 -0.31 7.48e-9 Systemic lupus erythematosus; CRC cis rs4969178 0.965 rs8072632 chr17:76397830 T/C cg20026190 chr17:76395443 PGS1 0.4 6.2 0.32 1.73e-9 HDL cholesterol levels; CRC cis rs754466 0.651 rs11813532 chr10:79637991 T/C cg26805224 chr10:79626177 DLG5 -0.54 -8.07 -0.41 1.29e-14 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs2760061 0.583 rs1774757 chr1:228211135 C/G cg02753203 chr1:228287806 NA 0.88 13.06 0.58 1.07e-31 Diastolic blood pressure; CRC cis rs6912958 1.000 rs9294380 chr6:88152667 G/A cg12350822 chr6:88032061 C6orf162;GJB7 -0.36 -6.84 -0.35 3.85e-11 Monocyte percentage of white cells; CRC cis rs765787 0.530 rs12439643 chr15:45529767 A/G cg24006582 chr15:45444508 DUOX1 0.6 8.42 0.42 1.21e-15 Uric acid levels; CRC cis rs10256972 0.616 rs4585652 chr7:1145396 A/G cg09177884 chr7:1199841 ZFAND2A -0.4 -5.64 -0.3 3.67e-8 Longevity;Endometriosis; CRC trans rs10506458 0.834 rs12426893 chr12:63388120 G/T cg03429785 chr15:59498649 MYO1E;LDHAL6B -1.46 -21.02 -0.76 8.45e-63 Hemostatic factors and hematological phenotypes; CRC cis rs853679 0.517 rs4713143 chr6:28106759 A/C cg12963246 chr6:28129442 ZNF389 0.49 5.78 0.3 1.73e-8 Depression; CRC trans rs1728785 0.901 rs3087783 chr16:68599668 C/T cg04657470 chr2:198365150 HSPE1;HSPD1 0.75 8.72 0.43 1.36e-16 Ulcerative colitis; CRC cis rs910316 0.663 rs175034 chr14:75463687 T/G cg03030879 chr14:75389066 RPS6KL1 0.4 6.02 0.32 4.56e-9 Height; CRC cis rs6964587 1.000 rs10225885 chr7:91671007 A/G cg17063962 chr7:91808500 NA 0.78 13.5 0.6 2.29e-33 Breast cancer; CRC cis rs7959452 0.719 rs57954211 chr12:69748397 C/A cg20891283 chr12:69753455 YEATS4 0.87 15.36 0.65 1.65e-40 Blood protein levels; CRC cis rs3858526 0.635 rs2045046 chr11:5875867 A/C cg13902645 chr11:5959945 NA -0.55 -7.31 -0.37 2.06e-12 DNA methylation (variation); CRC cis rs8058578 1.000 rs8048448 chr16:30692208 T/C cg00531865 chr16:30841666 NA -0.46 -6.35 -0.33 7.11e-10 Multiple myeloma; CRC cis rs2153535 0.580 rs1577468 chr6:8444266 C/A cg07606381 chr6:8435919 SLC35B3 0.69 11.03 0.52 2.87e-24 Motion sickness; CRC cis rs1322639 0.531 rs11751421 chr6:169574993 T/C cg04662567 chr6:169592167 NA 0.31 5.82 0.31 1.41e-8 Pulse pressure; CRC cis rs6988636 1.000 rs16898084 chr8:124190377 A/T cg27053337 chr8:124217698 FAM83A 0.43 6.59 0.34 1.74e-10 Urinary uromodulin levels; CRC cis rs7772486 0.790 rs1062068 chr6:146207465 A/G cg13319975 chr6:146136371 FBXO30 -0.43 -6.51 -0.34 2.75e-10 Lobe attachment (rater-scored or self-reported); CRC cis rs6499129 0.867 rs11859352 chr16:67390448 A/G cg26727032 chr16:67993705 SLC12A4 -0.54 -6.36 -0.33 6.71e-10 Waist-to-hip ratio adjusted for body mass index; CRC cis rs6076065 0.548 rs1112819 chr20:23323987 A/G cg11657817 chr20:23433608 CST11 0.55 9.53 0.47 3.62e-19 Facial morphology (factor 15, philtrum width); CRC cis rs9640161 0.659 rs7788316 chr7:150013995 A/T cg27494647 chr7:150038898 RARRES2 0.35 5.8 0.3 1.56e-8 Blood protein levels;Circulating chemerin levels; CRC cis rs798766 1.000 rs798766 chr4:1734239 C/T cg05874882 chr4:1763078 NA 0.38 6.94 0.36 2.13e-11 Bladder cancer;Urinary bladder cancer; CRC cis rs10504229 0.683 rs16921817 chr8:58107563 A/T cg02725872 chr8:58115012 NA -0.66 -11.36 -0.53 1.85e-25 Developmental language disorder (linguistic errors); CRC cis rs10751667 0.643 rs7396046 chr11:937176 T/C cg06064525 chr11:970664 AP2A2 -0.31 -6.16 -0.32 2.18e-9 Alzheimer's disease (late onset); CRC cis rs847577 0.609 rs11768309 chr7:97773812 G/T cg21770322 chr7:97807741 LMTK2 0.86 19.33 0.73 3.72e-56 Breast cancer; CRC cis rs394563 0.601 rs432582 chr6:149794143 C/T cg11245181 chr6:149772854 ZC3H12D -0.48 -7.52 -0.38 5.34e-13 Dupuytren's disease; CRC trans rs9815354 0.857 rs12108064 chr3:42016217 C/T cg04440885 chr16:51146856 NA 0.52 6.04 0.32 4.21e-9 Pulse pressure;Diastolic blood pressure; CRC cis rs909674 0.865 rs5757682 chr22:39848259 T/G cg11247378 chr22:39784982 NA -0.36 -6.51 -0.34 2.89e-10 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; CRC cis rs2239547 0.603 rs12489490 chr3:53064022 C/A cg11645453 chr3:52864694 ITIH4 0.49 7.48 0.38 6.88e-13 Schizophrenia; CRC cis rs4664293 0.867 rs12617546 chr2:160623590 G/A cg08347373 chr2:160653686 CD302 -0.47 -7.43 -0.38 9.32e-13 Monocyte percentage of white cells; CRC cis rs7937682 0.889 rs479667 chr11:111484034 C/T cg09085632 chr11:111637200 PPP2R1B -1.0 -19.99 -0.74 9.26e-59 Primary sclerosing cholangitis; CRC cis rs2832191 0.791 rs2832186 chr21:30484151 A/C cg08807101 chr21:30365312 RNF160 -0.65 -10.51 -0.5 1.83e-22 Dental caries; CRC cis rs7224685 0.501 rs7222628 chr17:3890429 A/G cg09695851 chr17:3907499 NA 0.84 16.38 0.67 1.64e-44 Type 2 diabetes; CRC cis rs6594499 0.872 rs7702774 chr5:110460851 G/T cg04022379 chr5:110408740 TSLP 0.47 7.31 0.37 2.11e-12 Allergic disease (asthma, hay fever or eczema); CRC cis rs2952156 0.876 rs903504 chr17:37829570 C/G cg00129232 chr17:37814104 STARD3 -0.7 -12.16 -0.56 2.34e-28 Asthma; CRC cis rs734999 0.588 rs745367 chr1:2524457 T/C cg18854424 chr1:2615690 NA 0.5 9.88 0.48 2.55e-20 Ulcerative colitis; CRC cis rs9287719 0.624 rs10199831 chr2:10726863 T/C cg00105475 chr2:10696890 NA 0.44 7.0 0.36 1.43e-11 Prostate cancer; CRC cis rs853679 0.760 rs9295768 chr6:28209102 G/A cg21251018 chr6:28226885 NKAPL 0.51 5.95 0.31 6.9e-9 Depression; CRC cis rs6960043 0.875 rs10249299 chr7:15054391 C/T cg19272540 chr7:15055459 NA 0.23 6.54 0.34 2.39e-10 Type 2 diabetes; CRC cis rs875971 0.965 rs6971509 chr7:65714970 G/T cg11764359 chr7:65958608 NA -0.62 -9.89 -0.48 2.34e-20 Aortic root size; CRC cis rs6964587 1.000 rs6967256 chr7:91643219 G/A cg17063962 chr7:91808500 NA 0.83 15.01 0.64 3.56e-39 Breast cancer; CRC cis rs9399135 0.967 rs34546690 chr6:135369709 T/C cg24558204 chr6:135376177 HBS1L 0.49 7.72 0.39 1.42e-13 Red blood cell count; CRC cis rs8177179 0.967 rs6439434 chr3:133450371 T/G cg16262614 chr3:133464971 TF 0.5 9.58 0.47 2.47e-19 Iron status biomarkers (transferrin levels); CRC cis rs1568889 0.667 rs16917914 chr11:28459909 C/T cg06544937 chr11:28130018 METT5D1;KIF18A 0.59 7.91 0.4 4.03e-14 Bipolar disorder; CRC cis rs9910055 0.762 rs2631299 chr17:42219773 G/T cg19774624 chr17:42201019 HDAC5 -0.65 -9.56 -0.47 2.96e-19 Total body bone mineral density; CRC cis rs3741404 0.620 rs882147 chr11:63976689 T/A cg15107132 chr11:63991130 FERMT3 -0.39 -6.37 -0.33 6.23e-10 Platelet count; CRC cis rs853679 0.599 rs149949 chr6:28011516 T/C cg03623178 chr6:28175578 NA 0.81 7.83 0.4 6.91e-14 Depression; CRC cis rs919433 0.963 rs12618612 chr2:198171058 G/T cg03934865 chr2:198174659 NA -0.45 -7.12 -0.37 6.84e-12 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC cis rs76878669 0.561 rs12794121 chr11:66126169 G/T cg24851651 chr11:66362959 CCS -0.38 -6.56 -0.34 2.09e-10 Educational attainment (years of education); CRC cis rs9359856 0.564 rs72915933 chr6:90441464 C/T cg13799429 chr6:90582589 CASP8AP2 -0.72 -7.66 -0.39 2.07e-13 Bipolar disorder; CRC cis rs7703744 0.681 rs11957102 chr5:118701899 G/T cg02283238 chr5:118691126 TNFAIP8 0.45 6.04 0.32 4.08e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs11148252 0.740 rs9596648 chr13:52934569 A/T cg12458913 chr13:53173898 NA -0.5 -7.49 -0.38 6.3e-13 Lewy body disease; CRC cis rs8072100 0.967 rs12452315 chr17:45479446 G/T cg25173405 chr17:45401733 C17orf57 0.51 8.36 0.42 1.77e-15 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs425277 0.628 rs10797427 chr1:2060732 C/T cg12639453 chr1:2035780 PRKCZ -0.42 -8.33 -0.42 2.2e-15 Height; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg27186011 chr3:49840712 C3orf54 0.42 6.09 0.32 3.09e-9 Anxiety disorder; CRC cis rs3760982 0.813 rs8104447 chr19:44293278 T/C cg21496419 chr19:44306685 LYPD5 -0.32 -5.76 -0.3 1.98e-8 Breast cancer (estrogen-receptor negative);Breast cancer; CRC cis rs6752107 0.500 rs11893210 chr2:234204672 A/G cg07618928 chr2:234183455 ATG16L1;SCARNA5 0.43 6.83 0.35 4.07e-11 Crohn's disease;Inflammatory bowel disease; CRC cis rs35110281 0.782 rs4818856 chr21:45043495 A/G cg01579765 chr21:45077557 HSF2BP -0.38 -7.31 -0.37 2.09e-12 Mean corpuscular volume; CRC cis rs644799 0.930 rs3802764 chr11:95514599 T/A cg25622487 chr11:95524042 FAM76B;CEP57 0.76 11.68 0.54 1.28e-26 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs11997175 0.545 rs7818001 chr8:33807682 G/T ch.8.33884649F chr8:33765107 NA 0.44 5.99 0.31 5.4e-9 Body mass index; CRC cis rs300703 0.719 rs385272 chr2:206704 A/G cg21211680 chr2:198530 NA -0.91 -11.47 -0.53 7.68e-26 Blood protein levels; CRC cis rs10883723 0.810 rs2296586 chr10:104245575 C/T cg22532475 chr10:104410764 TRIM8 -0.36 -6.64 -0.34 1.29e-10 Allergic disease (asthma, hay fever or eczema); CRC cis rs28386778 0.897 rs2236737 chr17:61938100 C/T cg11494091 chr17:61959527 GH2 0.59 9.93 0.48 1.66e-20 Prudent dietary pattern; CRC trans rs7395662 0.591 rs7483212 chr11:48607182 T/A cg00717180 chr2:96193071 NA -0.37 -5.97 -0.31 6.27e-9 HDL cholesterol; CRC cis rs7044106 0.791 rs7036196 chr9:123479457 A/G cg09586646 chr9:123605570 PSMD5;LOC253039 0.66 9.62 0.47 1.82e-19 Hip circumference adjusted for BMI; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg26980138 chr12:68726465 MDM1 0.43 6.12 0.32 2.72e-9 Intelligence (multi-trait analysis); CRC cis rs7312933 0.576 rs11181364 chr12:42567800 C/T cg11827402 chr12:42719852 PPHLN1;ZCRB1 0.65 9.07 0.45 1.1e-17 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CRC cis rs875971 0.862 rs778705 chr7:65861115 G/A cg00343986 chr7:65444356 GUSB 0.45 6.22 0.32 1.52e-9 Aortic root size; CRC cis rs7845219 0.544 rs7017487 chr8:95922752 A/G cg16049864 chr8:95962084 TP53INP1 0.45 6.76 0.35 6.23e-11 Type 2 diabetes; CRC cis rs2839186 0.868 rs2839199 chr21:47708269 T/C cg09417038 chr21:47716443 C21orf57 -0.42 -6.93 -0.36 2.21e-11 Testicular germ cell tumor; CRC cis rs10870270 0.957 rs3829156 chr10:133789386 C/G cg17892150 chr10:133769511 PPP2R2D -0.72 -11.01 -0.52 3.22e-24 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; CRC cis rs2652834 1.000 rs4344684 chr15:63397318 C/T cg05507819 chr15:63340323 TPM1 0.46 5.97 0.31 6.13e-9 HDL cholesterol; CRC cis rs4713118 0.527 rs35949862 chr6:28115367 A/G cg18032046 chr6:28092343 ZSCAN16 -0.51 -5.93 -0.31 7.47e-9 Parkinson's disease; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg05977900 chr3:182512126 ATP11B 0.5 6.37 0.33 6.24e-10 Thyroid stimulating hormone; CRC cis rs2153535 0.580 rs1577470 chr6:8462426 G/A cg21535247 chr6:8435926 SLC35B3 0.49 7.43 0.38 9.44e-13 Motion sickness; CRC cis rs10540 1.000 rs12801148 chr11:511707 T/G cg03934478 chr11:495069 RNH1 0.7 7.84 0.4 6.44e-14 Body mass index; CRC cis rs7119 0.604 rs2271398 chr15:77907784 G/A cg27398640 chr15:77910606 LINGO1 0.41 7.77 0.39 1.03e-13 Type 2 diabetes; CRC cis rs9287719 0.649 rs10183359 chr2:10733044 G/A cg00105475 chr2:10696890 NA 0.44 7.0 0.36 1.43e-11 Prostate cancer; CRC cis rs1046896 0.512 rs3785513 chr17:80886748 G/A cg08200770 chr17:80723486 TBCD -0.41 -6.57 -0.34 1.98e-10 Glycated hemoglobin levels; CRC cis rs755249 0.567 rs3754346 chr1:39814960 C/T cg18385671 chr1:39797026 MACF1 -0.41 -5.77 -0.3 1.81e-8 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs7666738 0.830 rs13108705 chr4:99044438 T/C cg05340658 chr4:99064831 C4orf37 0.6 9.35 0.46 1.36e-18 Colonoscopy-negative controls vs population controls; CRC cis rs1670533 1.000 rs12645644 chr4:1054159 C/T cg27284194 chr4:1044797 NA 0.48 6.27 0.33 1.11e-9 Recombination rate (females); CRC cis rs3849570 1.000 rs11915016 chr3:81833966 G/A cg07356753 chr3:81810745 GBE1 -0.73 -11.17 -0.52 8.96e-25 Waist circumference;Body mass index; CRC cis rs9911578 1.000 rs12936058 chr17:57017420 T/C cg05425664 chr17:57184151 TRIM37 -0.49 -7.8 -0.39 8.34e-14 Intelligence (multi-trait analysis); CRC trans rs9388451 0.626 rs3734637 chr6:126081319 G/T cg05039488 chr6:79577232 IRAK1BP1 -0.73 -12.49 -0.57 1.4e-29 Brugada syndrome; CRC cis rs909674 0.818 rs5750830 chr22:39840828 C/A cg24399712 chr22:39784796 NA -0.43 -8.02 -0.4 1.84e-14 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; CRC cis rs1799949 0.965 rs34616041 chr17:41188786 G/A cg19454999 chr17:41278357 BRCA1;NBR2 0.52 7.75 0.39 1.14e-13 Menopause (age at onset); CRC cis rs2075371 1.000 rs2598294 chr7:133991690 C/T cg02659138 chr7:134003124 SLC35B4 0.37 6.41 0.33 5.12e-10 Mean platelet volume; CRC cis rs6912958 0.703 rs12207825 chr6:88098292 C/T cg04972856 chr6:88032051 C6orf162;GJB7 0.33 6.07 0.32 3.5e-9 Monocyte percentage of white cells; CRC cis rs1577917 0.839 rs6454504 chr6:86580330 C/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.44 -5.81 -0.31 1.48e-8 Response to antipsychotic treatment; CRC trans rs9858542 0.953 rs9841110 chr3:49492481 C/G cg21659725 chr3:3221576 CRBN -0.66 -8.98 -0.44 2.18e-17 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs2479724 0.870 rs3747753 chr6:41753380 G/T cg17623882 chr6:41773611 USP49 0.57 9.78 0.47 5.51e-20 Menarche (age at onset); CRC cis rs2032447 0.520 rs198818 chr6:26125711 A/C cg03517284 chr6:25882590 NA 0.41 5.61 0.3 4.19e-8 Intelligence (multi-trait analysis); CRC cis rs853679 1.000 rs1936365 chr6:28268452 C/G cg15786705 chr6:28176104 NA -0.55 -5.99 -0.31 5.54e-9 Depression; CRC cis rs4713118 0.513 rs202908 chr6:28011551 C/G cg15845792 chr6:28175446 NA 0.77 11.41 0.53 1.22e-25 Parkinson's disease; CRC cis rs526821 0.789 rs10896993 chr11:55303410 A/G cg04317927 chr11:55418816 OR4S2 0.42 7.46 0.38 7.7e-13 Pediatric bone mineral density (spine); CRC cis rs1552244 0.832 rs3732968 chr3:10013273 A/G cg00166722 chr3:10149974 C3orf24 0.63 8.25 0.41 3.98e-15 Alzheimer's disease; CRC cis rs1552244 0.572 rs17032440 chr3:10169819 A/C cg08888203 chr3:10149979 C3orf24 -0.72 -8.81 -0.44 7.32e-17 Alzheimer's disease; CRC trans rs11039798 0.541 rs12283728 chr11:48796407 G/A cg03929089 chr4:120376271 NA 0.63 6.01 0.31 4.92e-9 Axial length; CRC cis rs9322193 0.923 rs4870509 chr6:150023348 C/G cg00933542 chr6:150070202 PCMT1 0.31 6.29 0.33 1.02e-9 Lung cancer; CRC trans rs8002861 0.664 rs2325089 chr13:44450222 C/G cg17145862 chr1:211918768 LPGAT1 -0.58 -10.09 -0.49 5.01e-21 Leprosy; CRC cis rs6088590 0.930 rs6120723 chr20:33364655 C/T cg08999081 chr20:33150536 PIGU 0.5 8.31 0.42 2.54e-15 Coronary artery disease; CRC cis rs9311474 0.508 rs1570 chr3:52586682 T/A cg15147215 chr3:52552868 STAB1 -0.65 -11.31 -0.53 2.75e-25 Electroencephalogram traits; CRC cis rs1707322 1.000 rs7547189 chr1:46319514 C/A cg03146154 chr1:46216737 IPP 0.5 6.95 0.36 1.97e-11 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs13118159 0.550 rs1137789 chr4:1381798 A/G cg02018176 chr4:1364513 KIAA1530 0.69 11.83 0.55 3.7e-27 Longevity; CRC cis rs10791097 0.694 rs7125622 chr11:130743388 T/C cg12179176 chr11:130786555 SNX19 0.75 12.66 0.57 3.28e-30 Autism spectrum disorder or schizophrenia;Schizophrenia; CRC cis rs1949733 0.635 rs4358384 chr4:8536913 C/T cg11789530 chr4:8429930 ACOX3 -0.58 -8.06 -0.41 1.4e-14 Response to antineoplastic agents; CRC cis rs6570726 0.599 rs426371 chr6:145886469 A/G cg05347473 chr6:146136440 FBXO30 -0.51 -7.4 -0.38 1.16e-12 Lobe attachment (rater-scored or self-reported); CRC cis rs9302635 0.513 rs3902135 chr16:72175820 C/T cg23815491 chr16:72088622 HP 0.64 8.12 0.41 9.28e-15 Blood protein levels; CRC cis rs7202877 0.706 rs2059257 chr16:75396376 G/A cg03315344 chr16:75512273 CHST6 0.49 5.9 0.31 8.99e-9 Type 2 diabetes;Type 1 diabetes; CRC cis rs9303401 0.538 rs8078280 chr17:56473132 A/G cg10487724 chr17:56770010 TEX14;RAD51C 0.71 8.68 0.43 1.93e-16 Cognitive test performance; CRC cis rs9534288 0.797 rs2182483 chr13:46582600 C/T cg15192986 chr13:46630673 CPB2 -0.66 -9.53 -0.47 3.46e-19 Blood protein levels; CRC cis rs7607369 0.536 rs6436091 chr2:219669141 T/C cg02176678 chr2:219576539 TTLL4 -0.37 -5.9 -0.31 8.89e-9 Red blood cell count;Amyotrophic lateral sclerosis; CRC cis rs4924997 0.772 rs2018675 chr17:19441531 A/G cg19949948 chr17:19361230 NA 0.36 6.2 0.32 1.64e-9 Lymphocyte counts; CRC cis rs6764363 0.535 rs331897 chr3:279688 G/A cg02057681 chr3:285234 CHL1 0.48 7.62 0.39 2.71e-13 Sudden cardiac arrest; CRC cis rs9783347 1.000 rs4353250 chr11:18323517 T/C cg15585147 chr11:18324498 HPS5 0.43 6.03 0.32 4.37e-9 Pancreatic cancer; CRC cis rs3540 0.554 rs4244879 chr15:91066915 C/T cg22089800 chr15:90895588 ZNF774 -0.58 -9.55 -0.47 3.2e-19 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; CRC cis rs17234274 0.622 rs16910894 chr11:23238516 C/G cg05245346 chr11:23248277 NA 0.34 5.63 0.3 3.79e-8 Cancer; CRC cis rs35110281 0.840 rs2838331 chr21:45026728 A/G cg04455712 chr21:45112962 RRP1B -0.42 -8.27 -0.41 3.45e-15 Mean corpuscular volume; CRC cis rs870825 0.616 rs4610378 chr4:185624220 C/T cg04058563 chr4:185651563 MLF1IP -0.71 -9.19 -0.45 4.51e-18 Blood protein levels; CRC trans rs10242455 0.702 rs73401510 chr7:99065812 A/C cg09045935 chr12:6379348 NA 1.14 9.25 0.45 2.99e-18 Blood metabolite levels; CRC cis rs9311474 0.507 rs6787154 chr3:52784416 C/T cg18404041 chr3:52824283 ITIH1 -0.41 -8.56 -0.43 4.4e-16 Electroencephalogram traits; CRC cis rs921968 0.613 rs6436066 chr2:219578361 T/G cg02176678 chr2:219576539 TTLL4 -0.45 -7.15 -0.37 5.52e-12 Mean corpuscular hemoglobin concentration; CRC cis rs9303401 0.614 rs35057477 chr17:57097064 G/A cg10487724 chr17:56770010 TEX14;RAD51C 0.76 9.21 0.45 3.97e-18 Cognitive test performance; CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg18640608 chr19:13001970 GCDH -0.51 -6.05 -0.32 4e-9 Diisocyanate-induced asthma; CRC cis rs34172651 0.917 rs8043962 chr16:24781372 A/G cg00339695 chr16:24857497 SLC5A11 0.27 6.39 0.33 5.57e-10 Intelligence (multi-trait analysis); CRC cis rs7224685 0.501 rs812996 chr17:3965674 T/C cg11204139 chr17:3907470 NA 0.75 14.23 0.62 3.77e-36 Type 2 diabetes; CRC cis rs11758351 1.000 rs3734530 chr6:26195408 G/C cg01420254 chr6:26195488 NA 0.83 8.68 0.43 1.82e-16 Gout;Renal underexcretion gout; CRC cis rs11031096 0.782 rs11031110 chr11:4162652 G/C cg18678763 chr11:4115507 RRM1 -0.51 -8.43 -0.42 1.09e-15 Mean corpuscular volume;Mean corpuscular hemoglobin; CRC cis rs3091242 0.933 rs9438904 chr1:25756860 T/C cg23205692 chr1:25664452 TMEM50A 0.42 6.03 0.32 4.31e-9 Erythrocyte sedimentation rate; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg20877313 chr12:56881753 GLS2 0.43 6.24 0.33 1.38e-9 Response to antipsychotic treatment; CRC cis rs6942756 0.956 rs7792317 chr7:128963971 G/A cg02491457 chr7:128862824 NA -0.74 -9.84 -0.48 3.28e-20 White matter hyperintensity burden; CRC cis rs12908161 0.959 rs62019472 chr15:85331493 A/G cg11189052 chr15:85197271 WDR73 0.59 8.36 0.42 1.75e-15 Schizophrenia; CRC cis rs2486012 0.850 rs42962 chr1:44298564 A/C cg12908607 chr1:44402522 ARTN -0.41 -5.94 -0.31 7.1e-9 Intelligence (multi-trait analysis); CRC cis rs2204008 0.774 rs11495520 chr12:38060605 T/G cg26384229 chr12:38710491 ALG10B 0.69 9.17 0.45 5.4e-18 Bladder cancer; CRC cis rs870825 0.616 rs6552808 chr4:185642865 G/T cg04058563 chr4:185651563 MLF1IP 0.72 9.42 0.46 8.15e-19 Blood protein levels; CRC cis rs10484885 0.793 rs9359862 chr6:90474508 A/G cg13799429 chr6:90582589 CASP8AP2 0.75 9.77 0.47 5.9e-20 QRS interval (sulfonylurea treatment interaction); CRC cis rs72781680 0.848 rs715646 chr2:24010566 G/A cg08917208 chr2:24149416 ATAD2B 0.84 8.11 0.41 1e-14 Lymphocyte counts; CRC cis rs72781680 0.898 rs79023848 chr2:24038174 C/A cg08917208 chr2:24149416 ATAD2B 1.0 9.7 0.47 9.69e-20 Lymphocyte counts; CRC cis rs2108225 0.900 rs2395930 chr7:107451677 T/C cg18560240 chr7:107437656 SLC26A3 -0.6 -9.24 -0.45 3.24e-18 Ulcerative colitis; CRC cis rs11229555 0.834 rs7925560 chr11:58263036 G/A cg15696309 chr11:58395628 NA -0.94 -12.64 -0.57 4.16e-30 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; CRC cis rs35110281 0.633 rs762400 chr21:45113629 C/G cg04455712 chr21:45112962 RRP1B -0.4 -8.0 -0.4 2.19e-14 Mean corpuscular volume; CRC cis rs6088590 1.000 rs6087625 chr20:33342477 A/G cg08999081 chr20:33150536 PIGU -0.51 -8.98 -0.44 2.13e-17 Coronary artery disease; CRC trans rs2727020 0.729 rs2866328 chr11:49282421 A/G cg03929089 chr4:120376271 NA 0.81 13.74 0.6 2.82e-34 Coronary artery disease; CRC cis rs7827545 1.000 rs6578234 chr8:135566363 A/G cg17885191 chr8:135476712 NA 0.53 6.95 0.36 1.99e-11 Hypertension (SNP x SNP interaction); CRC cis rs8141529 0.719 rs5762880 chr22:29287816 T/G cg02153584 chr22:29168773 CCDC117 0.46 6.61 0.34 1.51e-10 Lymphocyte counts; CRC cis rs897984 0.762 rs897986 chr16:30980902 T/C cg02466173 chr16:30829666 NA 0.62 9.32 0.46 1.78e-18 Dementia with Lewy bodies; CRC cis rs4665809 0.590 rs2891496 chr2:26452605 G/A cg26119090 chr2:26468346 HADHA;HADHB 1.06 15.53 0.65 3.62e-41 Gut microbiome composition (summer); CRC cis rs847577 0.715 rs12665986 chr7:97719676 A/G cg24562669 chr7:97807699 LMTK2 -0.68 -12.88 -0.58 5.32e-31 Breast cancer; CRC cis rs9361491 0.657 rs7382016 chr6:79455781 A/T cg05283184 chr6:79620031 NA 0.38 5.82 0.31 1.38e-8 Intelligence (multi-trait analysis); CRC cis rs1348850 0.539 rs1453371 chr2:178227862 T/G cg22681709 chr2:178499509 PDE11A -0.31 -5.71 -0.3 2.5e-8 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs61160187 0.582 rs10939879 chr5:60315823 T/C cg16298547 chr5:60138761 ELOVL7 -0.26 -5.73 -0.3 2.3e-8 Educational attainment (years of education);Educational attainment (college completion); CRC cis rs2635047 0.713 rs9304344 chr18:44758665 A/C cg19077165 chr18:44547161 KATNAL2 0.43 6.29 0.33 1.03e-9 Educational attainment; CRC cis rs3849570 0.615 rs9817070 chr3:81982936 A/G cg07356753 chr3:81810745 GBE1 -0.47 -6.39 -0.33 5.64e-10 Waist circumference;Body mass index; CRC cis rs875971 0.964 rs6978429 chr7:65959876 T/G cg18876405 chr7:65276391 NA 0.51 8.78 0.44 9.39e-17 Aortic root size; CRC cis rs1707322 1.000 rs11211219 chr1:46359478 G/C cg06784218 chr1:46089804 CCDC17 0.52 9.08 0.45 1.05e-17 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs9611565 0.559 rs4822049 chr22:41993496 G/A cg06634786 chr22:41940651 POLR3H -0.62 -6.38 -0.33 6.07e-10 Vitiligo; CRC cis rs4713118 0.662 rs9468275 chr6:28026136 G/T cg12273811 chr6:28175739 NA 0.62 8.29 0.42 2.87e-15 Parkinson's disease; CRC cis rs9911578 0.692 rs412000 chr17:56709058 G/C cg05425664 chr17:57184151 TRIM37 -0.41 -6.27 -0.33 1.17e-9 Intelligence (multi-trait analysis); CRC cis rs4285028 0.948 rs2877560 chr3:121699238 C/A cg20356878 chr3:121714668 ILDR1 -0.47 -6.91 -0.36 2.59e-11 Multiple sclerosis; CRC cis rs5753618 0.561 rs2078803 chr22:31652852 G/A cg22777020 chr22:31556080 RNF185 -0.53 -6.14 -0.32 2.34e-9 Colorectal cancer; CRC cis rs2361718 0.501 rs8065486 chr17:78138196 A/G cg27427491 chr17:78079615 GAA 0.44 5.98 0.31 5.67e-9 Yeast infection; CRC cis rs4953076 0.573 rs6734443 chr2:44408282 G/C cg04920474 chr2:44395004 PPM1B 0.58 8.12 0.41 9.54e-15 Height; CRC cis rs2197308 0.765 rs12824529 chr12:37931656 T/C cg26384229 chr12:38710491 ALG10B 0.68 8.97 0.44 2.37e-17 Morning vs. evening chronotype; CRC cis rs782590 0.967 rs782588 chr2:55841640 T/C cg18811423 chr2:55921094 PNPT1 0.81 14.77 0.63 3.04e-38 Metabolic syndrome; CRC cis rs59901009 0.863 rs56758314 chr11:10192648 C/T cg23875677 chr11:10229755 SBF2 -0.48 -6.08 -0.32 3.37e-9 Hematocrit;Hemoglobin concentration; CRC cis rs13082711 0.871 rs73046194 chr3:27454558 C/T cg02860705 chr3:27208620 NA 0.59 8.55 0.43 4.66e-16 Systolic blood pressure;Diastolic blood pressure;Blood pressure; CRC trans rs1814175 0.935 rs11040463 chr11:49685574 C/T cg15704280 chr7:45808275 SEPT13 -0.98 -18.3 -0.71 4.33e-52 Height; CRC trans rs1005277 0.602 rs1831315 chr10:38473353 T/C cg23533926 chr12:111358616 MYL2 -0.54 -8.02 -0.4 1.85e-14 Extrinsic epigenetic age acceleration; CRC cis rs3806843 0.966 rs2563266 chr5:140136915 C/A cg19875535 chr5:140030758 IK -0.59 -9.67 -0.47 1.2e-19 Depressive symptoms (multi-trait analysis); CRC cis rs798554 0.660 rs2283783 chr7:2855326 G/A cg09658497 chr7:2847517 GNA12 -0.37 -5.86 -0.31 1.14e-8 Height; CRC cis rs17376456 0.825 rs12716453 chr5:93271697 T/C cg09848695 chr5:92956644 FAM172A;MIR2277 0.68 6.03 0.32 4.45e-9 Diabetic retinopathy; CRC cis rs6582630 0.576 rs4882372 chr12:38356609 C/A cg13010199 chr12:38710504 ALG10B -0.4 -5.69 -0.3 2.75e-8 Drug-induced liver injury (flucloxacillin); CRC cis rs13191362 1.000 rs13206253 chr6:163166902 A/G cg06582575 chr6:163149167 PACRG;PARK2 0.79 10.72 0.51 3.49e-23 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs731174 0.797 rs686083 chr1:38149193 C/T cg06917450 chr1:38156652 C1orf109 -0.5 -7.16 -0.37 5.4e-12 Prostate cancer (SNP x SNP interaction); CRC cis rs17767392 0.958 rs9323561 chr14:72031563 A/C cg13720639 chr14:72061746 SIPA1L1 0.56 6.98 0.36 1.68e-11 Mitral valve prolapse; CRC cis rs9487023 1 rs9487023 chr6:109590004 A/G cg01475377 chr6:109611718 NA -0.45 -8.05 -0.41 1.51e-14 Red blood cell count;Mean corpuscular hemoglobin concentration;Neutrophil percentage of white cells;Lymphocyte percentage of white cells;Mean corpuscular hemoglobin;High light scatter reticulocyte percentage of red cells;Mean corpuscular volume; CRC cis rs853679 0.517 rs55747925 chr6:28044337 T/C cg21251018 chr6:28226885 NKAPL 0.47 6.16 0.32 2.07e-9 Depression; CRC cis rs11098499 0.954 rs13145352 chr4:120409963 C/T cg24375607 chr4:120327624 NA -0.49 -7.47 -0.38 7.44e-13 Corneal astigmatism; CRC cis rs7937682 0.961 rs7106104 chr11:111635655 T/C cg09085632 chr11:111637200 PPP2R1B 1.05 20.97 0.76 1.32e-62 Primary sclerosing cholangitis; CRC cis rs2180341 0.883 rs9388568 chr6:127690694 C/A cg24812749 chr6:127587940 RNF146 0.92 13.17 0.59 4.28e-32 Breast cancer; CRC cis rs875971 0.964 rs6945019 chr7:65922458 C/G cg11764359 chr7:65958608 NA 0.61 9.65 0.47 1.47e-19 Aortic root size; CRC cis rs7552404 1.000 rs7548962 chr1:76139266 G/A cg10523679 chr1:76189770 ACADM 0.83 11.5 0.54 6.08e-26 Blood metabolite levels;Acylcarnitine levels; CRC cis rs12137294 0.866 rs1172151 chr1:205221659 A/C cg24159697 chr1:205181237 DSTYK -0.32 -5.88 -0.31 9.96e-9 Red cell distribution width; CRC cis rs9488822 0.636 rs12201275 chr6:116314563 C/G cg18764771 chr6:116381957 FRK 0.24 6.91 0.36 2.57e-11 Cholesterol, total;LDL cholesterol; CRC cis rs8180040 0.764 rs13084117 chr3:47183239 C/A cg02527881 chr3:46936655 PTH1R -0.4 -7.44 -0.38 8.8e-13 Colorectal cancer; CRC trans rs7176508 0.636 rs7179415 chr15:70045786 C/T cg06571387 chr2:176964101 HOXD12 -0.32 -6.06 -0.32 3.73e-9 Chronic lymphocytic leukemia; CRC cis rs9341808 0.754 rs9361591 chr6:80953255 C/A cg08355045 chr6:80787529 NA 0.42 6.71 0.35 8.63e-11 Sitting height ratio; CRC cis rs10751667 0.666 rs7394958 chr11:965944 C/G cg06064525 chr11:970664 AP2A2 -0.3 -6.11 -0.32 2.78e-9 Alzheimer's disease (late onset); CRC cis rs2839186 0.609 rs2839189 chr21:47694357 C/T cg20399509 chr21:47717575 C21orf57 0.39 6.2 0.32 1.72e-9 Testicular germ cell tumor; CRC cis rs8077889 0.917 rs72836556 chr17:41911824 G/T cg16892393 chr17:41919603 NA 0.61 8.73 0.43 1.28e-16 Triglycerides; CRC cis rs7666738 0.830 rs11935588 chr4:98979862 A/G cg17366294 chr4:99064904 C4orf37 -0.44 -7.33 -0.37 1.8e-12 Colonoscopy-negative controls vs population controls; CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg02628353 chr7:26241504 HNRNPA2B1;CBX3 -0.51 -6.19 -0.32 1.82e-9 Diisocyanate-induced asthma; CRC cis rs3760776 1.000 rs3760776 chr19:5839746 C/T cg25387410 chr19:5844109 FUT3 -0.7 -9.45 -0.46 6.51e-19 N-glycan levels;Tumor biomarkers;Vitamin B12 levels; CRC cis rs6952808 0.717 rs6967442 chr7:1926090 A/G cg21782813 chr7:2030301 MAD1L1 0.38 6.86 0.35 3.42e-11 Bipolar disorder and schizophrenia; CRC trans rs9747201 0.925 rs8072670 chr17:80159566 T/C cg07393940 chr7:158741817 NA 0.49 7.17 0.37 4.91e-12 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs7617773 0.539 rs2017859 chr3:48382261 G/A cg11946769 chr3:48343235 NME6 0.6 8.14 0.41 8.14e-15 Coronary artery disease; CRC cis rs10857712 0.703 rs1056521 chr10:135235890 T/C cg01444801 chr10:135216882 MTG1 -0.55 -7.89 -0.4 4.61e-14 Systemic lupus erythematosus; CRC trans rs7937682 0.889 rs12360825 chr11:111528786 A/T cg18187862 chr3:45730750 SACM1L 0.49 7.04 0.36 1.16e-11 Primary sclerosing cholangitis; CRC trans rs208520 0.802 rs4710315 chr6:66887594 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.91 -12.38 -0.56 3.59e-29 Exhaled nitric oxide output; CRC cis rs9303401 0.573 rs35104446 chr17:57180234 A/C cg02118635 chr17:56770003 RAD51C;TEX14 0.65 8.01 0.4 1.95e-14 Cognitive test performance; CRC cis rs10782582 0.593 rs79552201 chr1:76215497 A/T cg10523679 chr1:76189770 ACADM -0.42 -6.01 -0.31 4.85e-9 Daytime sleep phenotypes; CRC cis rs1008375 0.932 rs6449317 chr4:17631253 T/C cg16339924 chr4:17578868 LAP3 0.58 7.18 0.37 4.7e-12 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs6921919 0.583 rs35599905 chr6:28379663 C/T cg21251018 chr6:28226885 NKAPL 0.39 5.93 0.31 7.61e-9 Autism spectrum disorder or schizophrenia; CRC cis rs1387259 0.723 rs2732488 chr12:48771444 G/A cg24011408 chr12:48396354 COL2A1 0.44 6.13 0.32 2.5e-9 Obstructive sleep apnea trait (apnea hypopnea index); CRC cis rs17023223 0.537 rs2765542 chr1:119560326 T/A cg05756136 chr1:119680316 WARS2 -0.52 -7.02 -0.36 1.28e-11 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for BMI in active individuals; CRC cis rs6460942 1.000 rs6460935 chr7:12401317 A/T cg20607287 chr7:12443886 VWDE -0.67 -6.78 -0.35 5.55e-11 Coronary artery disease; CRC cis rs9788721 0.836 rs2656065 chr15:78750549 G/A cg18825076 chr15:78729989 IREB2 -0.42 -6.53 -0.34 2.51e-10 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio;Emphysema imaging phenotypes;Emphysema distribution in smoking;Local histogram emphysema pattern;Post bronchodilator FEV1/FVC ratio in COPD; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg24047259 chr14:65347275 NA 0.4 6.42 0.33 4.7e-10 Liver disease severity in Alagille syndrome; CRC cis rs6163 0.588 rs67506723 chr10:104509064 G/T cg04362960 chr10:104952993 NT5C2 0.47 6.94 0.36 2.13e-11 Waist circumference;Hip circumference; CRC cis rs2290159 0.800 rs28462331 chr3:12660466 G/C cg23032965 chr3:12705835 RAF1 0.47 6.31 0.33 8.78e-10 Cholesterol, total; CRC cis rs4790333 0.845 rs7210932 chr17:2272024 A/G cg02569219 chr17:2266849 SGSM2 -0.51 -9.02 -0.45 1.61e-17 Proinsulin levels; CRC trans rs561341 0.714 rs55925849 chr17:30253085 C/T cg20587970 chr11:113659929 NA -1.42 -20.14 -0.74 2.38e-59 Hip circumference adjusted for BMI; CRC cis rs796364 0.806 rs6435041 chr2:200867144 A/G cg25936922 chr2:200820526 C2orf60;C2orf47 0.68 6.63 0.34 1.34e-10 Schizophrenia; CRC cis rs1707322 1.000 rs7527079 chr1:46413450 C/G cg06784218 chr1:46089804 CCDC17 0.51 9.06 0.45 1.19e-17 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC trans rs875971 0.660 rs2191268 chr7:66110224 C/T cg19161053 chr7:99036702 CPSF4;PTCD1 -0.39 -6.06 -0.32 3.7e-9 Aortic root size; CRC cis rs11605275 1.000 rs77993017 chr11:20031388 C/G cg14835545 chr11:20032148 NAV2 -0.83 -5.64 -0.3 3.57e-8 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs60871478 1.000 rs62432250 chr7:801792 C/G cg05535760 chr7:792225 HEATR2 0.78 10.08 0.49 5.47e-21 Cerebrospinal P-tau181p levels; CRC cis rs13191362 0.935 rs34347104 chr6:163055716 C/T cg23758597 chr6:163146217 PARK2 -0.68 -6.73 -0.35 7.44e-11 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs6860806 0.661 rs2136188 chr5:131577514 A/G cg18758796 chr5:131593413 PDLIM4 -0.45 -8.41 -0.42 1.29e-15 Breast cancer; CRC cis rs2732480 0.557 rs2732441 chr12:48723324 C/G cg21466736 chr12:48725269 NA -0.62 -9.33 -0.46 1.56e-18 Hemoglobin concentration;Red blood cell count;Hematocrit; CRC cis rs1707322 0.716 rs28375469 chr1:46195375 T/C cg03146154 chr1:46216737 IPP 0.68 9.85 0.48 3.13e-20 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs8114671 0.562 rs3818273 chr20:33509275 G/A cg07148914 chr20:33460835 GGT7 0.39 6.41 0.33 4.92e-10 Height; CRC cis rs7618915 0.547 rs12487591 chr3:52642936 A/T cg11645453 chr3:52864694 ITIH4 0.34 6.06 0.32 3.66e-9 Bipolar disorder; CRC cis rs174601 0.861 rs174550 chr11:61571478 T/C cg06781209 chr11:61594997 FADS2 -0.38 -5.74 -0.3 2.11e-8 Blood metabolite levels;Red blood cell fatty acid levels;Liver enzyme levels (alkaline phosphatase);Gondoic acid (20:1n-9) levels;Trans fatty acid levels; CRC cis rs910316 0.967 rs11624893 chr14:75660124 A/G cg08847533 chr14:75593920 NEK9 -0.85 -14.63 -0.63 1.07e-37 Height; CRC cis rs7737355 0.947 rs3776028 chr5:130789750 G/A cg06307176 chr5:131281290 NA -0.43 -6.43 -0.33 4.55e-10 Life satisfaction; CRC cis rs832540 0.593 rs96844 chr5:56196604 G/A cg12311346 chr5:56204834 C5orf35 -0.54 -8.06 -0.41 1.4e-14 Coronary artery disease; CRC cis rs10870270 1.000 rs10870232 chr10:133738537 T/G cg17892150 chr10:133769511 PPP2R2D -0.71 -10.85 -0.51 1.21e-23 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; CRC cis rs7618501 0.602 rs2240327 chr3:50113034 C/T cg05623727 chr3:50126028 RBM5 0.45 7.34 0.37 1.73e-12 Intelligence (multi-trait analysis); CRC cis rs7727544 1.000 rs10076701 chr5:131596419 A/G cg18301423 chr5:131593218 PDLIM4 0.33 6.34 0.33 7.49e-10 Blood metabolite levels; CRC trans rs61931739 0.534 rs10844800 chr12:34230734 A/G cg26384229 chr12:38710491 ALG10B 0.54 6.85 0.35 3.62e-11 Morning vs. evening chronotype; CRC cis rs5769707 0.904 rs7288869 chr22:50015327 C/T cg20744362 chr22:50050164 C22orf34 0.33 6.55 0.34 2.17e-10 Monocyte count;Monocyte percentage of white cells; CRC cis rs9325144 0.577 rs10876008 chr12:39126750 T/C cg26384229 chr12:38710491 ALG10B -0.48 -6.58 -0.34 1.86e-10 Morning vs. evening chronotype; CRC cis rs9326248 0.603 rs7396061 chr11:116750874 A/C cg01368799 chr11:117014884 PAFAH1B2 0.4 6.21 0.32 1.61e-9 Blood protein levels; CRC cis rs4819052 0.851 rs7281263 chr21:46695606 T/C cg02159808 chr21:46707872 POFUT2;LOC642852 0.51 6.71 0.35 8.75e-11 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs7727544 1.000 rs7727544 chr5:131590534 C/T cg12564285 chr5:131593104 PDLIM4 0.4 7.74 0.39 1.24e-13 Blood metabolite levels; CRC cis rs853679 0.517 rs55747925 chr6:28044337 T/C cg25164649 chr6:28176230 NA 0.72 9.1 0.45 9.16e-18 Depression; CRC cis rs2243480 1.000 rs34970380 chr7:65431493 C/T cg12463550 chr7:65579703 CRCP 0.67 6.37 0.33 6.3e-10 Diabetic kidney disease; CRC cis rs10486722 0.583 rs10251553 chr7:41762017 C/T cg22138096 chr7:41772439 LOC285954 0.4 5.95 0.31 6.84e-9 Pit-and-Fissure caries; CRC cis rs60871478 1.000 rs4719314 chr7:822523 A/G cg13844804 chr7:814759 HEATR2 0.66 8.42 0.42 1.21e-15 Cerebrospinal P-tau181p levels; CRC cis rs12497850 0.931 rs12493289 chr3:48905161 G/A cg20833759 chr3:49053208 WDR6;DALRD3 0.51 8.74 0.43 1.19e-16 Parkinson's disease; CRC cis rs7618915 0.547 rs2289250 chr3:52682946 A/C cg11645453 chr3:52864694 ITIH4 -0.34 -5.91 -0.31 8.79e-9 Bipolar disorder; CRC cis rs924607 1.000 rs11746907 chr5:598224 G/A cg09021430 chr5:549028 NA 0.53 8.98 0.44 2.09e-17 Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia; CRC cis rs35110281 0.633 rs4818860 chr21:45119617 C/T cg21573476 chr21:45109991 RRP1B -0.4 -6.03 -0.32 4.3e-9 Mean corpuscular volume; CRC cis rs4664293 0.867 rs3821299 chr2:160585740 C/A cg08347373 chr2:160653686 CD302 -0.47 -7.43 -0.38 9.32e-13 Monocyte percentage of white cells; CRC cis rs1577917 0.958 rs34622605 chr6:86456519 G/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.62 -7.88 -0.4 4.85e-14 Response to antipsychotic treatment; CRC cis rs1865760 0.713 rs1130000 chr6:25985396 A/G cg16482183 chr6:26056742 HIST1H1C 0.51 7.48 0.38 6.71e-13 Height; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg06028048 chr5:175815674 HIGD2A;NOP16 0.47 6.06 0.32 3.63e-9 Thyroid stimulating hormone; CRC cis rs3008870 1.000 rs12044278 chr1:67460977 T/C cg08660285 chr1:67390436 MIER1;WDR78 -1.04 -15.24 -0.64 4.66e-40 Lymphocyte percentage of white cells; CRC cis rs9325144 0.555 rs10748433 chr12:38696352 C/G cg26384229 chr12:38710491 ALG10B 0.57 8.53 0.43 5.43e-16 Morning vs. evening chronotype; CRC cis rs6952808 0.636 rs6964522 chr7:1953523 C/T cg02951883 chr7:2050386 MAD1L1 -0.54 -9.03 -0.45 1.45e-17 Bipolar disorder and schizophrenia; CRC cis rs10256972 0.553 rs4236381 chr7:1165723 A/C cg18765753 chr7:1198926 ZFAND2A -0.39 -6.49 -0.34 3.1e-10 Longevity;Endometriosis; CRC cis rs4731207 0.596 rs7788066 chr7:124630145 A/G cg23710748 chr7:124431027 NA -0.4 -6.36 -0.33 6.87e-10 Cutaneous malignant melanoma; CRC cis rs1862618 0.853 rs863840 chr5:56128999 C/G cg24531977 chr5:56204891 C5orf35 -0.76 -10.06 -0.49 6.05e-21 Initial pursuit acceleration; CRC cis rs4604732 0.588 rs74154678 chr1:247626202 A/T cg12758973 chr1:247694275 LOC148824;OR2C3 0.42 6.18 0.32 1.9e-9 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CRC cis rs9322193 0.923 rs4421206 chr6:150004027 A/C cg07701084 chr6:150067640 NUP43 0.56 8.2 0.41 5.41e-15 Lung cancer; CRC cis rs1448094 0.527 rs1900700 chr12:86232166 C/T cg18827107 chr12:86230957 RASSF9 -0.49 -7.82 -0.4 7.36e-14 Major depressive disorder; CRC cis rs28655083 0.529 rs4550465 chr16:77104785 A/G cg01753188 chr16:77233325 SYCE1L;MON1B 0.46 6.59 0.34 1.76e-10 Lobe attachment (rater-scored or self-reported); CRC cis rs5753618 0.583 rs8138596 chr22:31786961 T/A cg07713946 chr22:31675144 LIMK2 0.42 6.29 0.33 1.03e-9 Colorectal cancer; CRC cis rs950169 0.920 rs2135551 chr15:84707851 A/G cg24253500 chr15:84953950 NA 0.37 6.26 0.33 1.18e-9 Schizophrenia; CRC cis rs6502050 0.799 rs4789674 chr17:80123200 G/A cg13198984 chr17:80129470 CCDC57 0.47 8.27 0.41 3.34e-15 Life satisfaction; CRC cis rs96067 0.711 rs4653164 chr1:36627542 A/G cg25304816 chr1:36627734 MAP7D1 -0.57 -9.57 -0.47 2.62e-19 Corneal structure; CRC cis rs7945705 0.846 rs2742540 chr11:8899528 A/G cg12365402 chr11:9010492 NRIP3 0.46 7.75 0.39 1.18e-13 Hemoglobin concentration; CRC cis rs73206853 0.609 rs61582364 chr12:110967847 T/G cg12870014 chr12:110450643 ANKRD13A 0.81 9.47 0.46 5.52e-19 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC cis rs72945132 0.882 rs7129843 chr11:70180381 G/A cg00319359 chr11:70116639 PPFIA1 0.65 7.24 0.37 3.14e-12 Coronary artery disease; CRC cis rs2032447 0.714 rs129129 chr6:25961029 A/G cg12588279 chr6:26043732 HIST1H2BB 0.4 5.92 0.31 8.23e-9 Intelligence (multi-trait analysis); CRC cis rs798554 0.660 rs2644274 chr7:2854380 A/T cg17321639 chr7:2759063 NA -0.41 -6.18 -0.32 1.86e-9 Height; CRC cis rs6545883 0.507 rs34668697 chr2:61568349 T/A cg10580144 chr2:61372316 C2orf74 -0.35 -7.81 -0.4 7.95e-14 Tuberculosis; CRC cis rs8060686 0.641 rs1125333 chr16:68227566 C/A cg26727032 chr16:67993705 SLC12A4 -0.53 -6.24 -0.33 1.37e-9 HDL cholesterol;Metabolic syndrome; CRC cis rs9914988 0.943 rs9893782 chr17:27108132 C/T cg20469991 chr17:27169893 C17orf63 -0.6 -7.27 -0.37 2.59e-12 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs3772130 0.962 rs9883467 chr3:121517833 G/A cg20356878 chr3:121714668 ILDR1 0.51 8.05 0.41 1.5e-14 Cognitive performance; CRC cis rs897984 0.770 rs3813020 chr16:30934075 G/A cg02466173 chr16:30829666 NA 0.66 9.98 0.48 1.15e-20 Dementia with Lewy bodies; CRC cis rs57221529 0.709 rs72703034 chr5:577101 C/T cg09021430 chr5:549028 NA -0.72 -7.86 -0.4 5.63e-14 Lung disease severity in cystic fibrosis; CRC cis rs4731207 0.565 rs10954056 chr7:124600534 A/G cg23710748 chr7:124431027 NA -0.38 -6.08 -0.32 3.35e-9 Cutaneous malignant melanoma; CRC cis rs62229266 0.771 rs2835232 chr21:37393427 G/A cg12218747 chr21:37451666 NA -0.41 -7.0 -0.36 1.46e-11 Mitral valve prolapse; CRC cis rs7811142 0.830 rs11768967 chr7:99967644 G/A cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.61 8.02 0.4 1.83e-14 Platelet count; CRC cis rs1218582 0.774 rs4845680 chr1:154863195 A/G cg16680214 chr1:154839983 KCNN3 -0.48 -9.5 -0.46 4.65e-19 Prostate cancer; CRC cis rs6952808 1.000 rs10233560 chr7:1885415 T/C cg04267008 chr7:1944627 MAD1L1 -0.66 -9.55 -0.47 3e-19 Bipolar disorder and schizophrenia; CRC cis rs250677 0.687 rs250674 chr5:148438597 A/G cg18129178 chr5:148520854 ABLIM3 0.37 5.61 0.3 4.26e-8 Breast cancer; CRC trans rs701145 0.529 rs355759 chr3:154008078 G/C cg22545385 chr10:131989303 NA -0.43 -6.26 -0.33 1.19e-9 Coronary artery disease; CRC cis rs561341 1.000 rs506766 chr17:30289659 T/C cg12193833 chr17:30244370 NA -0.75 -8.45 -0.42 9.86e-16 Hip circumference adjusted for BMI; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg03117819 chr17:48610072 EPN3 0.46 6.63 0.34 1.4e-10 Response to antipsychotic treatment; CRC cis rs5769765 0.908 rs9616217 chr22:50318946 C/T cg26441486 chr22:50317300 CRELD2 0.35 5.83 0.31 1.33e-8 Schizophrenia; CRC cis rs9287719 0.967 rs6432126 chr2:10757101 A/G cg00105475 chr2:10696890 NA 0.44 7.14 0.37 6.13e-12 Prostate cancer; CRC cis rs853679 0.517 rs9468286 chr6:28079428 C/T cg06470822 chr6:28175283 NA 1.0 13.06 0.58 1.06e-31 Depression; CRC cis rs4665809 1.000 rs4665811 chr2:26260017 A/G cg04944784 chr2:26401820 FAM59B -0.6 -7.71 -0.39 1.53e-13 Gut microbiome composition (summer); CRC trans rs10504229 1.000 rs56168206 chr8:58184485 G/A cg04077850 chr5:125800366 GRAMD3 0.37 6.27 0.33 1.15e-9 Developmental language disorder (linguistic errors); CRC cis rs1215050 0.791 rs1215055 chr4:98865454 C/T cg05340658 chr4:99064831 C4orf37 -0.48 -7.2 -0.37 4.09e-12 Waist-to-hip ratio adjusted for body mass index; CRC trans rs9650657 0.571 rs4240673 chr8:10787612 T/C cg06636001 chr8:8085503 FLJ10661 -0.63 -9.24 -0.45 3.06e-18 Neuroticism; CRC cis rs6582630 0.573 rs12319414 chr12:38267440 T/C cg26384229 chr12:38710491 ALG10B -0.51 -7.32 -0.37 1.88e-12 Drug-induced liver injury (flucloxacillin); CRC cis rs28386778 0.897 rs2665823 chr17:61885917 G/A cg07362569 chr17:61921086 SMARCD2 0.38 5.94 0.31 7.13e-9 Prudent dietary pattern; CRC cis rs2456568 0.548 rs10501809 chr11:93666263 C/G cg26875233 chr11:93583750 C11orf90 -0.35 -6.79 -0.35 5.29e-11 Response to serotonin reuptake inhibitors in major depressive disorder; CRC cis rs4555082 0.645 rs2816605 chr14:105715515 C/T cg06808227 chr14:105710500 BRF1 -0.63 -8.84 -0.44 5.92e-17 Mean platelet volume;Platelet distribution width; CRC cis rs1008375 0.966 rs6832962 chr4:17652133 T/C cg16339924 chr4:17578868 LAP3 0.58 7.31 0.37 2.06e-12 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs4690686 0.509 rs11730559 chr4:177259257 A/T cg17059388 chr4:177262070 NA 0.38 5.69 0.3 2.76e-8 Essential tremor; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg08089031 chr6:139456240 HECA 0.39 6.21 0.32 1.57e-9 Liver disease severity in Alagille syndrome; CRC cis rs7945705 0.902 rs10743095 chr11:8936984 T/C cg21881798 chr11:8931708 C11orf17;ST5 0.7 11.14 0.52 1.15e-24 Hemoglobin concentration; CRC cis rs17376456 0.877 rs7701974 chr5:93311417 C/T cg09848695 chr5:92956644 FAM172A;MIR2277 0.63 5.67 0.3 3.18e-8 Diabetic retinopathy; CRC cis rs7659604 1.000 rs35249024 chr4:122664538 C/A cg06713675 chr4:122721982 EXOSC9 -0.38 -6.25 -0.33 1.26e-9 Type 2 diabetes; CRC cis rs883565 0.528 rs35946914 chr3:38992107 A/G cg01426195 chr3:39028469 NA -0.37 -6.05 -0.32 3.95e-9 Handedness; CRC cis rs6076065 0.723 rs2236022 chr20:23373534 G/A cg11657817 chr20:23433608 CST11 0.45 6.68 0.35 1.01e-10 Facial morphology (factor 15, philtrum width); CRC cis rs10193935 0.901 rs222483 chr2:42652184 T/G cg27598129 chr2:42591480 NA -0.65 -7.61 -0.39 2.98e-13 Colonoscopy-negative controls vs population controls; CRC cis rs798554 0.959 rs798528 chr7:2772431 A/C cg19717773 chr7:2847554 GNA12 -0.44 -6.26 -0.33 1.21e-9 Height; CRC trans rs10911184 0.818 rs4652756 chr1:182954072 T/C cg14803869 chr12:131237682 NA 0.53 6.21 0.32 1.56e-9 Diabetic kidney disease; CRC cis rs2046867 0.818 rs2208 chr3:72871773 A/G cg25664220 chr3:72788482 NA 0.44 7.06 0.36 1.01e-11 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; CRC cis rs7666738 0.830 rs28887893 chr4:98963006 G/A cg05340658 chr4:99064831 C4orf37 0.61 9.45 0.46 6.55e-19 Colonoscopy-negative controls vs population controls; CRC cis rs8014204 0.747 rs2070598 chr14:75360906 C/T cg08847533 chr14:75593920 NEK9 -0.44 -6.65 -0.34 1.25e-10 Caffeine consumption; CRC cis rs1048238 0.506 rs598371 chr1:16212739 G/A cg21385522 chr1:16154831 NA -0.63 -9.01 -0.44 1.76e-17 Systolic blood pressure; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg24531267 chr20:34043122 CEP250 0.41 6.79 0.35 5.16e-11 Liver disease severity in Alagille syndrome; CRC cis rs11148252 0.846 rs8001624 chr13:53002995 T/C cg02158880 chr13:53174818 NA 0.49 7.37 0.38 1.37e-12 Lewy body disease; CRC cis rs7618915 0.532 rs13060675 chr3:52674300 T/G cg15147215 chr3:52552868 STAB1 -0.62 -10.24 -0.49 1.48e-21 Bipolar disorder; CRC trans rs6561151 0.681 rs61209988 chr13:44416335 G/C cg12856521 chr11:46389249 DGKZ 0.73 10.56 0.5 1.21e-22 Crohn's disease; CRC cis rs1552244 0.882 rs13088350 chr3:10044626 T/C cg18598329 chr3:10140678 FANCD2;C3orf24 -0.81 -10.69 -0.51 4.35e-23 Alzheimer's disease; CRC cis rs736408 0.562 rs12497998 chr3:52793602 C/T cg11645453 chr3:52864694 ITIH4 0.38 6.67 0.35 1.05e-10 Bipolar disorder; CRC cis rs10751667 0.961 rs10902263 chr11:992691 A/C cg23136738 chr11:925521 AP2A2 0.48 7.61 0.39 2.92e-13 Alzheimer's disease (late onset); CRC trans rs2727020 0.576 rs61885308 chr11:49343363 G/A cg03929089 chr4:120376271 NA -0.62 -9.63 -0.47 1.75e-19 Coronary artery disease; CRC cis rs6968419 0.747 rs56293030 chr7:115857170 A/G cg02561103 chr7:115862891 TES -0.43 -6.48 -0.34 3.43e-10 Intraocular pressure; CRC cis rs10256972 0.758 rs2280724 chr7:1064720 A/G cg23708337 chr7:1209742 NA 0.38 5.69 0.3 2.84e-8 Longevity;Endometriosis; CRC cis rs4332037 0.906 rs6461009 chr7:1952139 T/C cg21155852 chr7:2048760 MAD1L1 0.45 6.28 0.33 1.05e-9 Bipolar disorder; CRC cis rs6963495 0.769 rs11556986 chr7:105177041 A/T cg13798780 chr7:105162888 PUS7 0.54 6.91 0.36 2.46e-11 Bipolar disorder (body mass index interaction); CRC cis rs116095464 0.558 rs6872854 chr5:209038 G/T cg22496380 chr5:211416 CCDC127 -0.79 -9.29 -0.46 2.23e-18 Breast cancer; CRC cis rs951366 0.617 rs823080 chr1:205789282 G/A cg26354017 chr1:205819088 PM20D1 0.94 16.29 0.67 3.81e-44 Menarche (age at onset); CRC cis rs5758659 0.737 rs10854749 chr22:42447341 G/T cg25452165 chr22:42524984 CYP2D6 0.39 5.63 0.3 3.79e-8 Cognitive function; CRC trans rs7726839 0.540 rs7434 chr5:660804 A/G cg11887960 chr12:57824829 NA -0.64 -7.32 -0.37 1.87e-12 Obesity-related traits; CRC cis rs17711722 0.701 rs781145 chr7:65440370 A/C cg18876405 chr7:65276391 NA 0.66 12.11 0.56 3.56e-28 Calcium levels; CRC cis rs4689592 0.587 rs6825954 chr4:7074226 T/C cg06697600 chr4:7070879 GRPEL1 -0.49 -7.07 -0.36 9.58e-12 Monocyte percentage of white cells; CRC cis rs1862618 0.573 rs832532 chr5:56221938 T/C cg12311346 chr5:56204834 C5orf35 -0.94 -13.06 -0.58 1.07e-31 Initial pursuit acceleration; CRC cis rs7909074 0.899 rs2026428 chr10:45389452 T/C cg05187965 chr10:45406764 TMEM72 -0.36 -8.3 -0.42 2.73e-15 Mean corpuscular volume; CRC trans rs3733585 0.673 rs4407505 chr4:9953367 T/G cg26043149 chr18:55253948 FECH -0.5 -7.71 -0.39 1.51e-13 Cleft plate (environmental tobacco smoke interaction); CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg13892980 chr15:40545143 PAK6;C15orf56 0.46 6.34 0.33 7.76e-10 Anxiety disorder; CRC cis rs6952808 0.609 rs11772205 chr7:1951236 C/T cg14004847 chr7:1930337 MAD1L1 -0.41 -5.98 -0.31 5.97e-9 Bipolar disorder and schizophrenia; CRC cis rs3741404 0.895 rs1860368 chr11:63994692 T/C cg19465662 chr11:63993652 NUDT22;TRPT1 -0.83 -13.82 -0.61 1.39e-34 Platelet count; CRC trans rs1979967 0.524 rs1979966 chr15:79659028 A/G cg14802097 chr12:42970349 PRICKLE1 0.52 6.06 0.32 3.66e-9 Interleukin-18 levels; CRC cis rs6840360 0.642 rs7682837 chr4:152427686 C/T cg09659197 chr4:152720779 NA 0.34 6.69 0.35 9.67e-11 Intelligence (multi-trait analysis); CRC cis rs561341 1.000 rs555629 chr17:30294136 T/C cg00745463 chr17:30367425 LRRC37B -0.9 -9.89 -0.48 2.27e-20 Hip circumference adjusted for BMI; CRC cis rs73200209 0.744 rs11615689 chr12:116699675 T/C cg01776926 chr12:116560359 MED13L -0.61 -7.2 -0.37 4.1e-12 Total body bone mineral density; CRC cis rs1401999 0.546 rs4148593 chr3:183649870 A/G cg05044414 chr3:183734942 ABCC5 0.35 5.96 0.31 6.56e-9 Anterior chamber depth; CRC cis rs1163251 0.756 rs539799 chr1:120208472 C/T cg19096424 chr1:120255104 PHGDH 0.37 5.76 0.3 1.89e-8 Blood metabolite levels; CRC cis rs6964587 1.000 rs6976122 chr7:91610962 T/C cg17063962 chr7:91808500 NA 0.8 14.25 0.62 3.13e-36 Breast cancer; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg00137828 chr10:105881754 C10orf78 0.4 6.05 0.32 4.03e-9 Intelligence (multi-trait analysis); CRC cis rs8060686 0.920 rs55661503 chr16:67836552 T/A cg07125278 chr16:67683757 RLTPR -0.62 -7.07 -0.36 9.54e-12 HDL cholesterol;Metabolic syndrome; CRC cis rs6088590 1.000 rs6119530 chr20:33403930 A/G cg24642439 chr20:33292090 TP53INP2 0.6 10.8 0.51 1.74e-23 Coronary artery disease; CRC cis rs7927592 0.913 rs6591346 chr11:68384618 T/A cg16797656 chr11:68205561 LRP5 0.37 6.32 0.33 8.33e-10 Total body bone mineral density; CRC cis rs8032158 1.000 rs7162435 chr15:56121334 C/T cg02198044 chr15:56286336 NEDD4 0.37 5.8 0.3 1.56e-8 Keloid; CRC cis rs10779751 0.770 rs11121696 chr1:11238063 A/G cg08854313 chr1:11322531 MTOR -0.53 -6.79 -0.35 5.19e-11 Body mass index; CRC cis rs875971 0.545 rs316305 chr7:65617971 G/A cg18876405 chr7:65276391 NA -0.44 -6.12 -0.32 2.73e-9 Aortic root size; CRC cis rs1881396 0.531 rs72613829 chr2:27902987 C/T cg27432699 chr2:27873401 GPN1 0.58 6.45 0.34 3.93e-10 Nonalcoholic fatty liver disease; CRC cis rs6694270 0.913 rs3935030 chr1:19116956 C/T cg19637330 chr1:19110922 NA -0.51 -6.99 -0.36 1.52e-11 Drug-induced liver injury (nitrofurantoin); CRC cis rs4555082 0.834 rs2816651 chr14:105708470 A/G cg06808227 chr14:105710500 BRF1 -0.63 -9.47 -0.46 5.56e-19 Mean platelet volume;Platelet distribution width; CRC cis rs9811920 0.638 rs7629426 chr3:99652577 C/G cg07805332 chr3:99536008 MIR548G;C3orf26 0.54 8.19 0.41 5.93e-15 Axial length; CRC cis rs4713118 0.955 rs9468203 chr6:27688667 A/G cg15845792 chr6:28175446 NA 0.58 7.47 0.38 7.16e-13 Parkinson's disease; CRC cis rs6738825 0.565 rs3792158 chr2:198407177 A/G cg10820045 chr2:198174542 NA 0.34 6.08 0.32 3.32e-9 Crohn's disease; CRC cis rs9399135 0.967 rs6908512 chr6:135367757 A/G cg22676075 chr6:135203613 NA 0.38 5.86 0.31 1.11e-8 Red blood cell count; CRC cis rs7589728 0.858 rs1914734 chr2:88529509 T/C cg04511125 chr2:88470314 THNSL2 0.58 6.69 0.35 9.64e-11 Plasma clusterin levels; CRC trans rs944990 0.595 rs10123378 chr9:96375217 C/T cg05952120 chr17:61554416 ACE 0.41 6.16 0.32 2.14e-9 Body mass index; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg25762580 chr7:108210082 THAP5;DNAJB9 0.49 6.27 0.33 1.14e-9 Thyroid stimulating hormone; CRC cis rs3096299 0.933 rs747485 chr16:89474094 T/C cg01788221 chr16:89496183 ANKRD11 -0.44 -6.87 -0.35 3.21e-11 Multiple myeloma (IgH translocation); CRC cis rs2839186 0.771 rs2280957 chr21:47642272 A/G cg11766577 chr21:47581405 C21orf56 0.51 8.25 0.41 3.98e-15 Testicular germ cell tumor; CRC cis rs11971779 0.680 rs4732369 chr7:139069173 C/A cg23387468 chr7:139079360 LUC7L2 0.41 7.08 0.36 8.84e-12 Diisocyanate-induced asthma; CRC cis rs17253792 0.822 rs28478195 chr14:56047851 G/A cg01858014 chr14:56050164 KTN1 -0.92 -8.25 -0.41 3.95e-15 Putamen volume; CRC cis rs11688816 0.904 rs2539984 chr2:63133584 G/C cg17519650 chr2:63277830 OTX1 0.42 5.8 0.3 1.57e-8 Body mass index; CRC cis rs9303401 0.614 rs3887355 chr17:56538639 T/C cg02118635 chr17:56770003 RAD51C;TEX14 0.77 9.6 0.47 2.14e-19 Cognitive test performance; CRC trans rs7937682 0.883 rs1784776 chr11:111472392 C/T cg18187862 chr3:45730750 SACM1L 0.46 6.56 0.34 2.15e-10 Primary sclerosing cholangitis; CRC trans rs150213942 1 rs150213942 chr3:135846911 T/G cg17080335 chr12:131030206 NA -0.4 -6.25 -0.33 1.24e-9 Fibrinogen levels; CRC cis rs10504229 0.683 rs61364624 chr8:58134339 T/A cg02725872 chr8:58115012 NA -0.64 -11.55 -0.54 3.85e-26 Developmental language disorder (linguistic errors); CRC cis rs2243480 1.000 rs778704 chr7:65863467 T/C cg12463550 chr7:65579703 CRCP 0.7 6.26 0.33 1.22e-9 Diabetic kidney disease; CRC cis rs611744 0.647 rs702808 chr8:109252554 T/C cg18478394 chr8:109455254 TTC35 0.37 5.78 0.3 1.75e-8 Dupuytren's disease; CRC cis rs4713118 0.527 rs35949862 chr6:28115367 A/G cg03623178 chr6:28175578 NA 0.98 12.66 0.57 3.31e-30 Parkinson's disease; CRC cis rs67311347 0.956 rs11714871 chr3:40428938 T/G cg09455208 chr3:40491958 NA 0.43 8.86 0.44 5.25e-17 Renal cell carcinoma; CRC cis rs1887596 0.705 rs11619978 chr13:27167841 A/G cg01312412 chr13:27282625 NA 0.44 6.03 0.32 4.51e-9 Facial morphology (factor 3, length of philtrum); CRC cis rs11971779 0.590 rs59602547 chr7:139117023 G/A cg07862535 chr7:139043722 LUC7L2 0.72 8.95 0.44 2.64e-17 Diisocyanate-induced asthma; CRC trans rs12517041 1.000 rs10066885 chr5:23296872 G/A ch.8.1293020R chr8:59333349 UBXN2B -0.55 -6.17 -0.32 2.05e-9 Calcium levels; CRC cis rs7618915 0.547 rs4687636 chr3:52633929 G/A cg05573699 chr3:52720067 GNL3;PBRM1 -0.44 -6.27 -0.33 1.16e-9 Bipolar disorder; CRC trans rs10875746 0.859 rs4760695 chr12:48591848 A/G cg16281234 chr15:35388805 NA -0.51 -6.4 -0.33 5.23e-10 Longevity (90 years and older); CRC cis rs1059312 0.771 rs11059922 chr12:129290418 C/T cg23521905 chr12:129298690 SLC15A4;MGC16384 0.37 6.51 0.34 2.85e-10 Systemic lupus erythematosus; CRC cis rs2839186 0.588 rs7280110 chr21:47619039 G/A cg12516959 chr21:47718080 NA 0.33 5.87 0.31 1.06e-8 Testicular germ cell tumor; CRC cis rs55823223 0.564 rs1463485 chr17:73851791 C/G cg24416660 chr17:73865998 NA -0.39 -5.95 -0.31 6.82e-9 Psoriasis; CRC cis rs6502050 0.765 rs6502075 chr17:80121813 G/A cg13198984 chr17:80129470 CCDC57 0.47 8.35 0.42 1.88e-15 Life satisfaction; CRC cis rs6502050 0.835 rs7212441 chr17:80080047 T/G cg19223190 chr17:80058835 NA -0.39 -6.09 -0.32 3.17e-9 Life satisfaction; CRC cis rs7937682 0.847 rs583032 chr11:111432757 C/T cg19812747 chr11:111475976 SIK2 -0.59 -9.89 -0.48 2.37e-20 Primary sclerosing cholangitis; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg22387939 chr2:71175719 ATP6V1B1 0.42 6.74 0.35 7.18e-11 Liver disease severity in Alagille syndrome; CRC cis rs7811142 1.000 rs6972167 chr7:100080013 G/T cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.92 12.29 0.56 8.06e-29 Platelet count; CRC cis rs10927875 0.541 rs761759 chr1:16342350 A/T cg24140574 chr1:16342155 HSPB7 0.47 6.67 0.34 1.12e-10 Dilated cardiomyopathy; CRC trans rs800082 0.516 rs1178895 chr3:144240563 G/T cg24215973 chr2:240111563 HDAC4 0.46 6.49 0.34 3.14e-10 Smoking behavior; CRC cis rs7772486 0.754 rs702304 chr6:145990797 A/G cg13319975 chr6:146136371 FBXO30 0.43 6.35 0.33 7.24e-10 Lobe attachment (rater-scored or self-reported); CRC cis rs4853012 0.838 rs12619982 chr2:74356022 G/A cg01017244 chr2:74357527 NA 0.76 10.04 0.48 7.05e-21 Gestational age at birth (maternal effect); CRC cis rs7851660 0.527 rs7859751 chr9:100575888 C/T cg13688889 chr9:100608707 NA -0.41 -5.79 -0.3 1.68e-8 Strep throat; CRC cis rs3857536 0.813 rs2040594 chr6:66943966 A/G cg07460842 chr6:66804631 NA -0.42 -5.72 -0.3 2.44e-8 Blood trace element (Cu levels); CRC cis rs4664293 0.625 rs4665102 chr2:160522587 A/C cg08347373 chr2:160653686 CD302 0.37 6.44 0.33 4.15e-10 Monocyte percentage of white cells; CRC cis rs732716 0.504 rs9352 chr19:4442336 C/T cg21934504 chr19:4445085 UBXN6 0.37 5.83 0.31 1.32e-8 Mean corpuscular volume; CRC cis rs8180040 0.726 rs2061197 chr3:47001350 C/T cg02527881 chr3:46936655 PTH1R 0.39 6.97 0.36 1.72e-11 Colorectal cancer; CRC cis rs28386778 0.897 rs2727287 chr17:61904728 G/A cg11494091 chr17:61959527 GH2 0.6 10.14 0.49 3.34e-21 Prudent dietary pattern; CRC cis rs3806843 0.832 rs2531360 chr5:140116664 G/A cg16607685 chr5:140181889 PCDHA2;PCDHA1;PCDHA3 0.25 5.96 0.31 6.42e-9 Depressive symptoms (multi-trait analysis); CRC cis rs853679 0.760 rs2299029 chr6:28198831 G/A cg02683197 chr6:28174875 NA 0.62 6.52 0.34 2.67e-10 Depression; CRC trans rs2303319 0.504 rs62189042 chr2:162602320 G/T cg22627826 chr19:1240265 ATP5D -0.72 -6.24 -0.33 1.32e-9 Cognitive function; CRC cis rs5753618 0.583 rs9606843 chr22:31853371 A/C cg07713946 chr22:31675144 LIMK2 0.38 5.84 0.31 1.28e-8 Colorectal cancer; CRC cis rs7647973 0.925 rs7429661 chr3:49228800 G/A cg20833759 chr3:49053208 WDR6;DALRD3 0.56 8.33 0.42 2.16e-15 Menarche (age at onset); CRC cis rs11229555 0.645 rs10896785 chr11:58233395 G/A cg15696309 chr11:58395628 NA -0.89 -11.49 -0.54 6.39e-26 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg17826168 chr19:6464103 CRB3 0.37 6.27 0.33 1.14e-9 Liver disease severity in Alagille syndrome; CRC cis rs17092148 1.000 rs60789653 chr20:33447162 G/A cg08999081 chr20:33150536 PIGU -0.46 -5.68 -0.3 2.91e-8 Neuroticism; CRC cis rs370915 0.578 rs1431929 chr4:187775324 A/G cg12892747 chr4:187813459 NA -0.56 -8.16 -0.41 7.22e-15 Gout; CRC cis rs7666738 0.830 rs13136930 chr4:98937933 A/T cg17366294 chr4:99064904 C4orf37 0.43 7.27 0.37 2.61e-12 Colonoscopy-negative controls vs population controls; CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg06925236 chr11:68039653 C11orf24 -0.5 -6.12 -0.32 2.6e-9 Diisocyanate-induced asthma; CRC trans rs7826238 0.566 rs2945886 chr8:8148270 C/G cg16141378 chr3:129829833 LOC729375 -0.42 -6.19 -0.32 1.78e-9 Systolic blood pressure; CRC cis rs929354 0.772 rs6957939 chr7:156978485 T/C cg05182265 chr7:156933206 UBE3C -0.76 -14.52 -0.62 3.01e-37 Body mass index; CRC cis rs13108904 0.901 rs6826029 chr4:1307689 A/G cg15763984 chr4:1342303 KIAA1530 0.35 6.1 0.32 2.98e-9 Obesity-related traits; CRC cis rs4730250 0.654 rs12705405 chr7:106792517 C/T cg02696742 chr7:106810147 HBP1 0.56 6.36 0.33 6.77e-10 Osteoarthritis; CRC cis rs113835537 0.735 rs519380 chr11:66409409 G/A cg22134325 chr11:66188745 NPAS4 0.38 7.55 0.38 4.36e-13 Airway imaging phenotypes; CRC cis rs6502050 0.835 rs7502078 chr17:80131879 C/A cg09264619 chr17:80180166 NA -0.34 -5.64 -0.3 3.74e-8 Life satisfaction; CRC cis rs8062405 0.964 rs72793809 chr16:28832382 C/T cg08761264 chr16:28874980 SH2B1 -0.42 -5.66 -0.3 3.26e-8 Cognitive ability (multi-trait analysis);Cognitive ability; CRC trans rs10411161 1.000 rs10414104 chr19:52368132 G/A cg22319618 chr22:45562946 NUP50 -0.52 -6.02 -0.31 4.57e-9 Breast cancer; CRC cis rs7666738 0.830 rs62318503 chr4:98935479 T/C cg17366294 chr4:99064904 C4orf37 0.43 7.32 0.37 1.95e-12 Colonoscopy-negative controls vs population controls; CRC cis rs3126085 0.935 rs10888471 chr1:152200849 G/T cg09127314 chr1:152161683 NA -0.45 -5.89 -0.31 9.5e-9 Atopic dermatitis; CRC cis rs796364 0.951 rs769952 chr2:200734368 C/T cg23649088 chr2:200775458 C2orf69 0.55 6.01 0.31 4.84e-9 Schizophrenia; CRC cis rs898097 0.841 rs4986136 chr17:80865119 A/G cg16060761 chr17:80687452 NA -0.4 -5.81 -0.3 1.51e-8 Breast cancer; CRC cis rs1448094 0.935 rs11117108 chr12:86322310 T/A cg02569458 chr12:86230093 RASSF9 0.37 6.46 0.34 3.67e-10 Major depressive disorder; CRC cis rs798554 0.567 rs1182192 chr7:2869274 G/A cg19717773 chr7:2847554 GNA12 -0.4 -6.75 -0.35 6.68e-11 Height; CRC cis rs9399135 0.935 rs9376086 chr6:135371329 T/C cg24558204 chr6:135376177 HBS1L 0.49 7.75 0.39 1.18e-13 Red blood cell count; CRC cis rs394563 0.559 rs7752555 chr6:149671116 A/G cg07828024 chr6:149772892 ZC3H12D 0.48 8.81 0.44 7.51e-17 Dupuytren's disease; CRC cis rs7618915 0.501 rs2289247 chr3:52727257 C/T cg10802521 chr3:52805072 NEK4 -0.58 -9.22 -0.45 3.66e-18 Bipolar disorder; CRC cis rs6585424 1.000 rs10466226 chr10:81924055 C/T cg11900509 chr10:81946545 ANXA11 0.72 8.55 0.43 4.75e-16 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs1670533 0.932 rs13140571 chr4:1054358 T/C cg27284194 chr4:1044797 NA 0.5 6.2 0.32 1.66e-9 Recombination rate (females); CRC cis rs7534824 0.543 rs12568993 chr1:101386259 A/C cg16556008 chr1:101360663 SLC30A7;EXTL2 0.57 5.87 0.31 1.04e-8 Refractive astigmatism; CRC cis rs2180341 1.000 rs2144743 chr6:127633810 A/T cg27446573 chr6:127587934 RNF146 0.97 14.29 0.62 2.32e-36 Breast cancer; CRC cis rs2188554 0.639 rs11978434 chr7:117231852 T/C cg09181792 chr7:117119393 CFTR 0.35 6.15 0.32 2.22e-9 Esophageal adenocarcinoma; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg02186127 chr17:33914245 AP2B1 0.49 6.26 0.33 1.2e-9 Thyroid stimulating hormone; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg15042806 chr16:23652268 DCTN5;PALB2 0.49 6.33 0.33 8.25e-10 Thyroid stimulating hormone; CRC cis rs7312933 0.558 rs1051453 chr12:42852217 C/T cg11827402 chr12:42719852 PPHLN1;ZCRB1 0.63 8.83 0.44 6.23e-17 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CRC cis rs11945232 1.000 rs10027786 chr4:88347512 A/G cg23841344 chr4:88312519 HSD17B11 -0.47 -5.99 -0.31 5.54e-9 Intelligence (multi-trait analysis); CRC cis rs185694 1.000 rs200505 chr13:30900868 G/T cg04551440 chr13:30881194 KATNAL1 -0.61 -6.32 -0.33 8.68e-10 Antineutrophil cytoplasmic antibody-associated vasculitis; CRC cis rs3790645 1.000 rs282176 chr1:26898956 T/C cg17456097 chr1:26900765 RPS6KA1 0.44 6.7 0.35 8.78e-11 Glucose homeostasis traits; CRC cis rs9443645 0.838 rs9350800 chr6:79729489 A/C cg05283184 chr6:79620031 NA -0.63 -9.89 -0.48 2.31e-20 Intelligence (multi-trait analysis); CRC cis rs4665809 0.941 rs7602922 chr2:26265782 C/T cg04944784 chr2:26401820 FAM59B -0.65 -7.96 -0.4 2.84e-14 Gut microbiome composition (summer); CRC cis rs7727544 0.716 rs4705928 chr5:131578637 A/G cg18758796 chr5:131593413 PDLIM4 -0.35 -6.27 -0.33 1.1e-9 Blood metabolite levels; CRC cis rs58688157 0.883 rs34793529 chr11:575800 T/G cg09218773 chr11:619014 MUPCDH -0.38 -5.91 -0.31 8.36e-9 Systemic lupus erythematosus; CRC cis rs798554 0.759 rs798495 chr7:2797267 T/C cg04166393 chr7:2884313 GNA12 0.51 6.87 0.35 3.31e-11 Height; CRC cis rs875971 0.522 rs6960048 chr7:65408039 A/G cg11764359 chr7:65958608 NA 0.5 7.7 0.39 1.62e-13 Aortic root size; CRC cis rs7605827 0.930 rs6431705 chr2:15599988 C/G cg19274914 chr2:15703543 NA -0.37 -5.69 -0.3 2.77e-8 Educational attainment (years of education); CRC trans rs561341 0.883 rs7219239 chr17:30212016 A/G cg27661571 chr11:113659931 NA 0.65 7.59 0.39 3.3e-13 Hip circumference adjusted for BMI; CRC cis rs35000415 0.873 rs13246321 chr7:128701331 T/C cg19972273 chr7:128594194 NA 0.71 6.15 0.32 2.2e-9 Systemic lupus erythematosus; CRC cis rs6499255 0.904 rs7190652 chr16:69616292 C/G cg04110750 chr16:69646130 NFAT5 -0.56 -7.57 -0.39 3.75e-13 IgE levels; CRC cis rs10504229 0.953 rs78089850 chr8:58171557 A/G cg22535103 chr8:58192502 C8orf71 -0.81 -11.92 -0.55 1.86e-27 Developmental language disorder (linguistic errors); CRC cis rs61008539 0.893 rs4719460 chr7:859610 C/T cg00934597 chr7:893267 UNC84A 0.58 8.14 0.41 8.33e-15 Perceived unattractiveness to mosquitoes; CRC cis rs1862618 0.671 rs832531 chr5:56228401 A/G cg20203395 chr5:56204925 C5orf35 -0.57 -7.85 -0.4 5.76e-14 Initial pursuit acceleration; CRC trans rs10504229 1.000 rs67594249 chr8:58180521 T/A cg04077850 chr5:125800366 GRAMD3 0.37 6.27 0.33 1.15e-9 Developmental language disorder (linguistic errors); CRC cis rs57590327 0.555 rs3755713 chr3:81811224 A/G cg07356753 chr3:81810745 GBE1 -0.63 -8.49 -0.42 6.97e-16 Extraversion; CRC cis rs2408955 0.561 rs9971924 chr12:48479832 C/G cg15465823 chr12:48382534 COL2A1 -0.36 -6.07 -0.32 3.59e-9 Glycated hemoglobin levels; CRC cis rs56307353 0.652 rs4807191 chr19:1990309 C/T cg08800497 chr19:1970008 CSNK1G2 -0.57 -9.07 -0.45 1.14e-17 Coronary artery disease; CRC trans rs2303319 0.504 rs58622044 chr2:162596287 A/G cg26358599 chr1:24018029 RPL11 -0.74 -6.02 -0.31 4.71e-9 Cognitive function; CRC cis rs514406 0.861 rs11206026 chr1:53281708 G/A cg25767906 chr1:53392781 SCP2 -0.46 -7.24 -0.37 3.15e-12 Monocyte count; CRC cis rs1799949 0.526 rs4352088 chr17:41414679 A/G cg05368731 chr17:41323189 NBR1 0.64 9.34 0.46 1.51e-18 Menopause (age at onset); CRC cis rs12188164 1.000 rs55842567 chr5:437586 G/A cg21972741 chr5:435613 AHRR 0.53 7.37 0.38 1.41e-12 Cystic fibrosis severity; CRC cis rs1799949 0.965 rs8176322 chr17:41195773 A/G cg05368731 chr17:41323189 NBR1 0.68 10.35 0.5 6.24e-22 Menopause (age at onset); CRC cis rs4478858 0.663 rs11591060 chr1:31780012 G/A cg07478791 chr1:31886160 SERINC2 -0.41 -5.74 -0.3 2.21e-8 Alcohol dependence; CRC cis rs34172651 0.537 rs8049014 chr16:24698903 A/G cg06028605 chr16:24865363 SLC5A11 0.41 6.42 0.33 4.88e-10 Intelligence (multi-trait analysis); CRC cis rs501120 0.584 rs11238915 chr10:44696665 C/A cg09554077 chr10:44749378 NA 0.69 7.91 0.4 4.04e-14 Coronary artery disease;Coronary heart disease; CRC cis rs7208859 0.673 rs999796 chr17:29159404 G/C cg13385521 chr17:29058706 SUZ12P 0.56 7.35 0.38 1.54e-12 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs4713118 0.869 rs2056925 chr6:27690905 A/G cg20933634 chr6:27740509 NA 0.59 8.74 0.43 1.19e-16 Parkinson's disease; CRC cis rs2976388 0.566 rs2585146 chr8:143798641 A/C cg12516270 chr8:143859308 LYNX1 0.45 7.3 0.37 2.21e-12 Urinary tract infection frequency; CRC cis rs9787249 0.957 rs11809515 chr1:40205326 C/A cg19912559 chr1:40204330 PPIE 0.51 7.39 0.38 1.2e-12 Blood protein levels; CRC cis rs6580649 1.000 rs7305954 chr12:48403530 C/T cg05342945 chr12:48394962 COL2A1 -0.39 -5.67 -0.3 3.06e-8 Lung cancer; CRC cis rs67311347 1.000 rs9834052 chr3:40399060 G/A cg09455208 chr3:40491958 NA 0.43 8.95 0.44 2.66e-17 Renal cell carcinoma; CRC cis rs1865760 0.963 rs9356991 chr6:25901758 C/A cg17691542 chr6:26056736 HIST1H1C 0.56 8.3 0.42 2.67e-15 Height; CRC cis rs78545713 0.649 rs77362785 chr6:26232351 G/A cg01420254 chr6:26195488 NA 0.72 6.03 0.32 4.42e-9 Iron status biomarkers (total iron binding capacity); CRC trans rs11098499 0.754 rs10212775 chr4:120239244 G/C cg25214090 chr10:38739885 LOC399744 0.53 8.45 0.42 9.68e-16 Corneal astigmatism; CRC cis rs9326248 0.817 rs1242127 chr11:117076564 A/G cg10130564 chr11:117069849 TAGLN -0.37 -6.53 -0.34 2.49e-10 Blood protein levels; CRC cis rs2204008 0.715 rs11514342 chr12:38236710 T/A cg13010199 chr12:38710504 ALG10B 0.45 5.82 0.31 1.39e-8 Bladder cancer; CRC cis rs514406 0.798 rs575138 chr1:53328394 C/G cg27535305 chr1:53392650 SCP2 -0.42 -7.51 -0.38 5.79e-13 Monocyte count; CRC cis rs7772486 0.875 rs932522 chr6:146374026 A/G cg23711669 chr6:146136114 FBXO30 -0.61 -10.54 -0.5 1.42e-22 Lobe attachment (rater-scored or self-reported); CRC cis rs11112613 0.609 rs11112585 chr12:105933442 A/G cg03607813 chr12:105948248 NA -0.75 -9.26 -0.45 2.73e-18 Corrected insulin response;Corrected insulin response adjusted for insulin sensitivity index; CRC trans rs7580658 0.614 rs7585198 chr2:127962635 C/T cg23503864 chr12:64616369 C12orf66 -0.45 -6.29 -0.33 1.01e-9 Protein C levels; CRC cis rs11098499 0.913 rs56122576 chr4:120129336 A/G cg09307838 chr4:120376055 NA 0.6 8.88 0.44 4.43e-17 Corneal astigmatism; CRC trans rs8108034 1.000 rs39587 chr19:39806997 C/T cg27350917 chr16:2021941 TBL3 -0.54 -6.52 -0.34 2.68e-10 Lung adenocarcinoma; CRC cis rs7119 0.717 rs12912386 chr15:77817640 T/C cg27398640 chr15:77910606 LINGO1 -0.43 -7.47 -0.38 7.13e-13 Type 2 diabetes; CRC cis rs59918340 0.764 rs10101692 chr8:142230823 C/T cg03316587 chr8:142245164 NA -0.39 -5.84 -0.31 1.24e-8 Immature fraction of reticulocytes; CRC cis rs1528435 1.000 rs1528446 chr2:181522955 A/C cg23363182 chr2:181467187 NA -0.35 -5.63 -0.3 3.92e-8 Body mass index; CRC cis rs9549367 0.774 rs9549696 chr13:113875062 C/T cg00898013 chr13:113819073 PROZ -0.44 -6.6 -0.34 1.67e-10 Platelet distribution width; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg24583131 chr6:18265189 DEK 0.49 6.44 0.33 4.18e-10 Thyroid stimulating hormone; CRC cis rs9916302 0.706 rs1054488 chr17:37687968 A/G cg07936489 chr17:37558343 FBXL20 -0.92 -11.86 -0.55 2.95e-27 Glomerular filtration rate (creatinine); CRC cis rs6724607 1.000 rs13006708 chr2:191471428 G/A cg10560079 chr2:191398806 TMEM194B -0.5 -7.2 -0.37 4.05e-12 Pulse pressure; CRC cis rs5750830 0.649 rs5757664 chr22:39821536 A/G cg24399712 chr22:39784796 NA -0.49 -9.83 -0.48 3.7799999999999997e-20 Intelligence (multi-trait analysis); CRC cis rs1670533 0.932 rs610218 chr4:1080083 C/G cg27284194 chr4:1044797 NA 0.49 6.24 0.33 1.37e-9 Recombination rate (females); CRC cis rs3931020 0.548 rs969435 chr1:75273866 A/G cg10128416 chr1:75198403 TYW3;CRYZ -0.5 -6.38 -0.33 6.04e-10 Resistin levels; CRC cis rs7666738 0.830 rs115712871 chr4:98954535 A/T cg17366294 chr4:99064904 C4orf37 0.43 7.34 0.38 1.69e-12 Colonoscopy-negative controls vs population controls; CRC cis rs9322193 0.923 rs9689716 chr6:149976798 G/A cg05861140 chr6:150128134 PCMT1 -0.36 -5.83 -0.31 1.36e-8 Lung cancer; CRC cis rs4563143 0.647 rs73029014 chr19:29257655 G/C cg14983838 chr19:29218262 NA 0.46 6.76 0.35 6.47e-11 Methadone dose in opioid dependence; CRC trans rs2303319 0.504 rs62187609 chr2:162431500 C/T cg10498984 chr16:28874827 SH2B1 -0.73 -5.97 -0.31 6.13e-9 Cognitive function; CRC cis rs1153858 1.000 rs12909158 chr15:45621174 A/G cg21132104 chr15:45694354 SPATA5L1 0.58 8.32 0.42 2.37e-15 Homoarginine levels; CRC cis rs2404602 0.669 rs17464903 chr15:77195486 A/G cg03037974 chr15:76606532 NA 0.68 11.44 0.53 9.97e-26 Blood metabolite levels; CRC cis rs2762353 0.595 rs10498728 chr6:25751320 A/T cg12310025 chr6:25882481 NA -0.76 -11.1 -0.52 1.59e-24 Blood metabolite levels; CRC cis rs57221529 0.713 rs56328416 chr5:591138 G/A cg16447950 chr5:562315 NA -0.78 -10.22 -0.49 1.82e-21 Lung disease severity in cystic fibrosis; CRC cis rs1552244 0.882 rs55962400 chr3:10044457 C/T cg00166722 chr3:10149974 C3orf24 0.62 7.67 0.39 1.94e-13 Alzheimer's disease; CRC trans rs11039798 0.920 rs11500574 chr11:48713986 A/T cg03929089 chr4:120376271 NA 0.63 6.06 0.32 3.73e-9 Axial length; CRC cis rs2949837 0.581 rs2965074 chr7:45983129 G/T cg04796162 chr7:45961102 IGFBP3 0.4 6.9 0.36 2.69e-11 Sitting height ratio; CRC cis rs9925964 0.933 rs9923231 chr16:31107689 C/T cg02466173 chr16:30829666 NA 0.41 5.65 0.3 3.43e-8 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs7959452 0.590 rs7968629 chr12:69782857 G/A cg20891283 chr12:69753455 YEATS4 0.91 17.07 0.69 3.06e-47 Blood protein levels; CRC cis rs832540 0.629 rs10055224 chr5:56081201 C/T cg12311346 chr5:56204834 C5orf35 0.5 7.51 0.38 5.53e-13 Coronary artery disease; CRC cis rs372883 0.532 rs425989 chr21:30715275 T/C cg24692254 chr21:30365293 RNF160 -0.44 -6.55 -0.34 2.17e-10 Pancreatic cancer; CRC cis rs10540 1.000 rs35255804 chr11:492617 G/A cg08200582 chr11:442649 ANO9 -0.71 -7.42 -0.38 9.82e-13 Body mass index; CRC cis rs35306767 0.761 rs12770173 chr10:1027108 A/C cg20503657 chr10:835505 NA 0.94 10.72 0.51 3.35e-23 Eosinophil percentage of granulocytes; CRC cis rs13256369 1.000 rs13271966 chr8:8575472 T/C cg06636001 chr8:8085503 FLJ10661 0.45 5.81 0.31 1.44e-8 Obesity-related traits; CRC cis rs1008375 0.902 rs12503164 chr4:17656107 C/T cg02297831 chr4:17616191 MED28 0.45 5.99 0.31 5.48e-9 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs3733585 0.699 rs7699609 chr4:9961059 A/G cg11266682 chr4:10021025 SLC2A9 -0.47 -9.67 -0.47 1.2e-19 Cleft plate (environmental tobacco smoke interaction); CRC cis rs763121 0.814 rs5757212 chr22:39053757 G/C cg06544989 chr22:39130855 UNC84B 0.45 7.26 0.37 2.85e-12 Menopause (age at onset); CRC cis rs28386778 0.897 rs2665844 chr17:61874455 A/G cg25654072 chr17:61904446 PSMC5;FTSJ3 0.74 11.5 0.54 6.02e-26 Prudent dietary pattern; CRC cis rs10426930 0.700 rs7253212 chr19:5021391 G/A cg25246084 chr19:4971487 KDM4B -0.35 -5.96 -0.31 6.64e-9 Monocyte percentage of white cells; CRC cis rs796364 1.000 rs796364 chr2:200716119 C/A cg23649088 chr2:200775458 C2orf69 0.57 6.28 0.33 1.08e-9 Schizophrenia; CRC cis rs4443100 0.631 rs13054904 chr22:23410918 A/T cg14186256 chr22:23484241 RTDR1 -0.47 -6.06 -0.32 3.74e-9 Serum parathyroid hormone levels; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg14797243 chr11:68671428 IGHMBP2;MRPL21 0.5 7.3 0.37 2.25e-12 Response to antipsychotic treatment; CRC cis rs9486719 1.000 rs1303852 chr6:96864523 C/T cg06623918 chr6:96969491 KIAA0776 0.81 9.48 0.46 5.18e-19 Migraine;Coronary artery disease; CRC cis rs644799 0.965 rs10831426 chr11:95505888 G/A cg25622487 chr11:95524042 FAM76B;CEP57 0.75 11.51 0.54 5.3e-26 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs9549328 0.700 rs4907568 chr13:113617574 A/T cg25790453 chr13:113633590 MCF2L -0.44 -7.77 -0.39 1.03e-13 Systolic blood pressure; CRC cis rs1555895 0.611 rs3763722 chr10:859270 C/T cg10556349 chr10:835070 NA -0.32 -6.0 -0.31 5.09e-9 Survival in rectal cancer; CRC cis rs10242455 0.702 rs73397499 chr7:99039627 T/C cg18809830 chr7:99032528 PTCD1 -1.14 -8.33 -0.42 2.26e-15 Blood metabolite levels; CRC cis rs204247 0.565 rs411094 chr6:13718264 C/A cg02206980 chr6:13574034 SIRT5 -0.49 -7.45 -0.38 8.27e-13 Breast cancer; CRC cis rs12142240 0.698 rs112089006 chr1:46812360 C/T cg14993813 chr1:46806288 NSUN4 -0.51 -6.48 -0.34 3.28e-10 Menopause (age at onset); CRC cis rs7208859 0.623 rs73271872 chr17:29152228 C/G cg13385521 chr17:29058706 SUZ12P 0.65 7.4 0.38 1.15e-12 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs644799 0.710 rs12272061 chr11:95524067 G/T cg25622487 chr11:95524042 FAM76B;CEP57 0.8 13.53 0.6 1.83e-33 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs9303401 0.703 rs9911583 chr17:57210721 A/G cg10487724 chr17:56770010 TEX14;RAD51C -0.46 -7.05 -0.36 1.06e-11 Cognitive test performance; CRC cis rs9527 0.615 rs4919685 chr10:104587362 G/T cg23093090 chr10:104574429 C10orf26 -0.41 -5.74 -0.3 2.13e-8 Arsenic metabolism; CRC trans rs944990 0.595 rs10123378 chr9:96375217 C/T cg06173978 chr16:50402162 BRD7 0.38 6.42 0.33 4.64e-10 Body mass index; CRC trans rs8002861 0.664 rs4942246 chr13:44404853 A/G cg12856521 chr11:46389249 DGKZ 0.43 6.85 0.35 3.7e-11 Leprosy; CRC cis rs7666738 0.830 rs13125537 chr4:98978428 A/G cg17366294 chr4:99064904 C4orf37 0.44 7.4 0.38 1.11e-12 Colonoscopy-negative controls vs population controls; CRC cis rs6831352 0.918 rs29001216 chr4:100051556 A/T cg13256891 chr4:100009986 ADH5 -0.66 -8.89 -0.44 4.04e-17 Alcohol dependence; CRC cis rs6988636 1.000 rs28542077 chr8:124190896 T/C cg27053337 chr8:124217698 FAM83A 0.43 6.59 0.34 1.74e-10 Urinary uromodulin levels; CRC cis rs6714710 0.603 rs11690687 chr2:98461821 C/T cg26665480 chr2:98280029 ACTR1B 0.52 7.11 0.37 7.13e-12 Posterior cortical atrophy and Alzheimer's disease; CRC cis rs6754311 0.550 rs1438307 chr2:136499166 A/C cg15123519 chr2:136567270 LCT -0.3 -5.75 -0.3 2.03e-8 Mosquito bite size; CRC cis rs1552244 0.572 rs58862481 chr3:10164308 G/A cg18598329 chr3:10140678 FANCD2;C3orf24 -0.91 -10.7 -0.51 3.85e-23 Alzheimer's disease; CRC cis rs3790844 0.955 rs3790848 chr1:200006111 C/A cg13229857 chr1:200006247 NR5A2 0.59 8.34 0.42 2.13e-15 Pancreatic cancer; CRC cis rs6693567 0.545 rs1260391 chr1:150373077 T/C cg04165759 chr1:150448943 RPRD2 0.34 5.61 0.3 4.2e-8 Migraine; CRC trans rs10838798 0.563 rs4752894 chr11:48120936 G/A cg21153622 chr11:89784906 NA -0.44 -6.99 -0.36 1.5e-11 Height; CRC cis rs10206020 0.885 rs11886082 chr2:1576683 T/C cg26248373 chr2:1572462 NA -0.81 -11.42 -0.53 1.13e-25 IgG glycosylation; CRC cis rs7618915 0.547 rs4687636 chr3:52633929 G/A cg08222913 chr3:52553049 STAB1 -0.34 -6.17 -0.32 1.98e-9 Bipolar disorder; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg09580147 chr16:22431764 RRN3P3 -0.4 -6.31 -0.33 9.22e-10 Liver disease severity in Alagille syndrome; CRC trans rs561341 1.000 rs548957 chr17:30302411 G/A cg27661571 chr11:113659931 NA -0.95 -11.14 -0.52 1.11e-24 Hip circumference adjusted for BMI; CRC cis rs798554 0.757 rs960273 chr7:2857876 T/C cg13628971 chr7:2884303 GNA12 0.54 7.24 0.37 3.12e-12 Height; CRC cis rs9322193 0.962 rs3805752 chr6:150116626 C/T cg04369109 chr6:150039330 LATS1 -0.45 -5.91 -0.31 8.44e-9 Lung cancer; CRC cis rs763014 0.932 rs35067229 chr16:649638 T/C cg04497992 chr16:616212 NHLRC4 0.44 7.16 0.37 5.31e-12 Height; CRC cis rs6570726 0.791 rs9390336 chr6:145896823 A/T cg05347473 chr6:146136440 FBXO30 0.38 5.86 0.31 1.15e-8 Lobe attachment (rater-scored or self-reported); CRC cis rs4563143 0.675 rs56123392 chr19:29255631 A/C cg12667521 chr19:29218732 NA 0.49 7.49 0.38 6.26e-13 Methadone dose in opioid dependence; CRC cis rs7949030 0.688 rs11231155 chr11:62365619 A/G cg22862634 chr11:62369728 EML3;MTA2 0.56 9.99 0.48 1.1e-20 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; CRC cis rs6952808 0.689 rs1107591 chr7:2041638 G/A cg21782813 chr7:2030301 MAD1L1 0.52 9.12 0.45 7.51e-18 Bipolar disorder and schizophrenia; CRC trans rs2303319 0.504 rs62189051 chr2:162622318 G/A cg22988483 chr14:93581567 ITPK1 -0.66 -6.08 -0.32 3.32e-9 Cognitive function; CRC cis rs4713118 0.955 rs9468203 chr6:27688667 A/G cg12273811 chr6:28175739 NA 0.5 6.83 0.35 4.15e-11 Parkinson's disease; CRC cis rs4660306 0.961 rs4660860 chr1:45946233 T/A cg03123370 chr1:45965343 CCDC163P;MMACHC -0.56 -7.85 -0.4 5.99e-14 Homocysteine levels; CRC trans rs916888 0.821 rs199509 chr17:44858728 G/A cg23590916 chr17:43697445 MGC57346 -0.57 -6.14 -0.32 2.32e-9 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs651907 0.514 rs12636046 chr3:101434448 T/G cg12386194 chr3:101231763 SENP7 0.5 7.29 0.37 2.39e-12 Colorectal cancer; CRC cis rs2070488 0.804 rs4678605 chr3:38444489 T/A cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.79 13.6 0.6 9.67e-34 Electrocardiographic conduction measures; CRC cis rs62064224 0.714 rs11657299 chr17:30634951 G/A cg09324608 chr17:30823087 MYO1D 0.36 6.31 0.33 8.91e-10 Schizophrenia; CRC cis rs4478858 0.698 rs4949204 chr1:31800415 A/G cg00250761 chr1:31883323 NA -0.44 -8.5 -0.42 6.71e-16 Alcohol dependence; CRC cis rs13108904 0.967 rs11730939 chr4:1285560 G/A cg02018176 chr4:1364513 KIAA1530 0.47 7.66 0.39 2.07e-13 Obesity-related traits; CRC cis rs9649213 0.593 rs7776638 chr7:97993506 C/T cg00277769 chr7:97922759 BAIAP2L1 -0.6 -10.39 -0.5 4.76e-22 Prostate cancer (SNP x SNP interaction); CRC cis rs2404602 0.716 rs117129193 chr15:76656803 A/G cg03037974 chr15:76606532 NA 0.71 12.52 0.57 1.12e-29 Blood metabolite levels; CRC cis rs7224737 0.956 rs8081900 chr17:40289875 G/A cg02450064 chr17:40260053 DHX58 -0.42 -6.12 -0.32 2.64e-9 Fibrinogen levels; CRC cis rs9916302 0.904 rs650106 chr17:37451559 A/G cg03013999 chr17:37608204 MED1 -0.48 -7.51 -0.38 5.62e-13 Glomerular filtration rate (creatinine); CRC cis rs11122272 0.705 rs1416914 chr1:231533196 C/T cg06096015 chr1:231504339 EGLN1 0.39 5.79 0.3 1.65e-8 Hemoglobin concentration; CRC cis rs1046896 0.594 rs9914570 chr17:80783721 C/T cg03160526 chr17:80928410 B3GNTL1 0.57 7.63 0.39 2.63e-13 Glycated hemoglobin levels; CRC cis rs72781680 1.000 rs72781631 chr2:24195064 G/A cg08917208 chr2:24149416 ATAD2B 0.79 8.46 0.42 8.82e-16 Lymphocyte counts; CRC cis rs910316 0.699 rs175039 chr14:75468950 G/C cg03030879 chr14:75389066 RPS6KL1 0.4 6.01 0.31 4.96e-9 Height; CRC cis rs2836974 0.644 rs2836981 chr21:40688365 C/T cg22974920 chr21:40686053 BRWD1 -0.43 -5.88 -0.31 9.95e-9 Cognitive function; CRC cis rs7215564 0.908 rs115148337 chr17:78688545 G/T cg09596252 chr17:78655493 RPTOR 0.59 6.33 0.33 8.02e-10 Myopia (pathological); CRC cis rs10870270 1.000 rs4880263 chr10:133787629 C/T cg17892150 chr10:133769511 PPP2R2D -0.75 -11.13 -0.52 1.21e-24 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; CRC cis rs6973256 0.828 rs12707117 chr7:133429058 G/A cg10665199 chr7:133106180 EXOC4 0.37 5.77 0.3 1.79e-8 Intelligence (multi-trait analysis); CRC cis rs634534 0.622 rs531612 chr11:65705432 C/T cg17985854 chr11:65770987 BANF1;EIF1AD -0.37 -5.84 -0.31 1.28e-8 Sum eosinophil basophil counts;Eosinophil counts; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg06310300 chr7:100076089 TSC22D4 0.46 6.68 0.35 1.03e-10 Response to antipsychotic treatment; CRC cis rs4589502 0.502 rs2169460 chr15:67197240 A/G cg09911534 chr15:67153556 NA 0.43 6.36 0.33 6.77e-10 Lung cancer (smoking interaction); CRC cis rs758324 0.947 rs10052255 chr5:131173106 C/T cg25547332 chr5:131281432 NA 0.38 5.64 0.3 3.67e-8 Alzheimer's disease in APOE e4- carriers; CRC cis rs4819052 1.000 rs2838830 chr21:46664227 T/G cg02159808 chr21:46707872 POFUT2;LOC642852 0.63 7.85 0.4 5.93e-14 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs2797685 1.000 rs2640908 chr1:7889941 C/T cg04725166 chr1:7887271 PER3 -0.48 -6.06 -0.32 3.69e-9 Crohn's disease; CRC cis rs6840360 0.615 rs1877188 chr4:152607931 T/C cg09659197 chr4:152720779 NA 0.4 7.9 0.4 4.19e-14 Intelligence (multi-trait analysis); CRC cis rs7618915 0.547 rs3755806 chr3:52643685 C/T cg08222913 chr3:52553049 STAB1 0.36 6.56 0.34 2.03e-10 Bipolar disorder; CRC cis rs2440129 0.632 rs2292353 chr17:6903537 C/T cg19536664 chr17:6899085 ALOX12 0.67 13.72 0.6 3.43e-34 Tonsillectomy; CRC cis rs58688157 0.705 rs12795572 chr11:590999 G/A cg16486109 chr11:613632 IRF7 0.73 12.28 0.56 8.42e-29 Systemic lupus erythematosus; CRC cis rs6502050 0.835 rs34199331 chr17:80134487 C/T cg19223190 chr17:80058835 NA 0.4 6.32 0.33 8.74e-10 Life satisfaction; CRC cis rs6582630 0.519 rs10880576 chr12:38497693 T/C cg26384229 chr12:38710491 ALG10B 0.69 9.75 0.47 6.75e-20 Drug-induced liver injury (flucloxacillin); CRC cis rs7927592 0.913 rs10896347 chr11:68353127 G/A cg16797656 chr11:68205561 LRP5 0.36 5.73 0.3 2.27e-8 Total body bone mineral density; CRC cis rs6163 0.588 rs10786706 chr10:104500659 C/T cg04362960 chr10:104952993 NT5C2 0.45 6.8 0.35 4.8e-11 Waist circumference;Hip circumference; CRC cis rs17021463 0.902 rs34465979 chr4:95257554 C/A cg11021082 chr4:95130006 SMARCAD1 0.52 8.02 0.4 1.91e-14 Testicular germ cell tumor; CRC trans rs66573146 0.656 rs66905212 chr4:6949508 G/C cg07817883 chr1:32538562 TMEM39B 1.26 12.27 0.56 9.31e-29 Granulocyte percentage of myeloid white cells; CRC cis rs7781557 0.696 rs55849741 chr7:102584069 C/G cg18108683 chr7:102477205 FBXL13 -0.49 -5.71 -0.3 2.48e-8 Colorectal adenoma (advanced); CRC cis rs1799949 1.000 rs8176077 chr17:41276348 T/C cg01879757 chr17:41196368 BRCA1 -0.43 -6.61 -0.34 1.54e-10 Menopause (age at onset); CRC cis rs10504229 0.683 rs55881798 chr8:58106406 T/C cg04204079 chr8:58130323 NA -0.46 -5.72 -0.3 2.37e-8 Developmental language disorder (linguistic errors); CRC cis rs4272321 1 rs4272321 chr7:157951835 A/G cg04622731 chr7:157956161 PTPRN2 -0.78 -13.34 -0.59 9.2e-33 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; CRC cis rs796364 1.000 rs4263095 chr2:200830137 A/C cg25936922 chr2:200820526 C2orf60;C2orf47 -0.7 -7.69 -0.39 1.74e-13 Schizophrenia; CRC cis rs6831352 0.918 rs17218108 chr4:100055755 T/C cg13256891 chr4:100009986 ADH5 -0.66 -8.89 -0.44 4.04e-17 Alcohol dependence; CRC cis rs8031584 0.541 rs2955777 chr15:31219788 A/C cg08704250 chr15:31115839 NA 0.31 5.74 0.3 2.13e-8 Huntington's disease progression; CRC cis rs1580019 0.665 rs34147895 chr7:32531796 G/C cg07520158 chr7:32535189 LSM5;AVL9 0.54 7.81 0.4 7.52e-14 Cognitive ability; CRC trans rs8002861 0.840 rs7989353 chr13:44438957 T/C cg17145862 chr1:211918768 LPGAT1 0.71 14.1 0.61 1.27e-35 Leprosy; CRC cis rs2549003 1.000 rs10214312 chr5:131821866 T/G cg02551604 chr5:131831745 NA -0.54 -8.34 -0.42 2e-15 Asthma (sex interaction); CRC cis rs600231 0.708 rs602838 chr11:65253247 T/G cg17120908 chr11:65337727 SSSCA1 -0.6 -8.92 -0.44 3.29e-17 Bone mineral density; CRC cis rs9403521 1.000 rs116980222 chr6:143998987 C/T cg18240653 chr6:144019428 PHACTR2 -0.55 -6.19 -0.32 1.77e-9 Obesity-related traits; CRC trans rs561341 0.700 rs6505266 chr17:30225813 G/A cg20587970 chr11:113659929 NA -0.57 -7.69 -0.39 1.73e-13 Hip circumference adjusted for BMI; CRC cis rs10791097 0.694 rs1893018 chr11:130756632 T/C cg12179176 chr11:130786555 SNX19 0.75 12.45 0.57 2e-29 Autism spectrum disorder or schizophrenia;Schizophrenia; CRC cis rs6426558 0.537 rs2718193 chr1:227404672 C/G cg10327440 chr1:227177885 CDC42BPA 0.42 6.22 0.32 1.5e-9 Neutrophil percentage of white cells; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg27657525 chr19:30432971 C19orf2 0.46 7.28 0.37 2.42e-12 Liver disease severity in Alagille syndrome; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg24512132 chr1:229478138 C1orf96 0.39 6.3 0.33 9.63e-10 Liver disease severity in Alagille syndrome; CRC cis rs2243480 1.000 rs316326 chr7:65609453 T/C cg25985355 chr7:65971099 NA -0.52 -6.1 -0.32 3.05e-9 Diabetic kidney disease; CRC cis rs9549260 0.592 rs9315783 chr13:41289164 T/C cg21288729 chr13:41239152 FOXO1 0.41 6.28 0.33 1.05e-9 Red blood cell count; CRC cis rs7618915 0.571 rs6762457 chr3:52609157 G/A cg15147215 chr3:52552868 STAB1 -0.63 -10.52 -0.5 1.72e-22 Bipolar disorder; CRC cis rs12188164 0.515 rs11742006 chr5:408529 C/T cg17553881 chr5:443987 EXOC3;C5orf55 -0.32 -6.51 -0.34 2.79e-10 Cystic fibrosis severity; CRC cis rs1799949 1.000 rs11649954 chr17:41420035 A/G cg23758822 chr17:41437982 NA 0.79 13.41 0.59 4.99e-33 Menopause (age at onset); CRC cis rs1799949 0.526 rs4352088 chr17:41414679 A/G cg25072359 chr17:41440525 NA 0.45 6.57 0.34 1.93e-10 Menopause (age at onset); CRC cis rs2806561 0.808 rs4654834 chr1:23364919 T/C cg19743168 chr1:23544995 NA -0.38 -6.08 -0.32 3.34e-9 Height; CRC cis rs6545883 0.826 rs777591 chr2:61417617 A/G cg15711740 chr2:61764176 XPO1 -0.42 -5.72 -0.3 2.39e-8 Tuberculosis; CRC cis rs3126085 0.778 rs10788828 chr1:152191879 G/A cg09127314 chr1:152161683 NA 0.5 6.38 0.33 5.92e-10 Atopic dermatitis; CRC cis rs932541 1.000 rs932541 chr20:16455774 G/T cg17003395 chr20:16555519 KIF16B 0.41 5.73 0.3 2.25e-8 Intelligence; CRC cis rs10857712 0.754 rs2297032 chr10:135234580 C/T cg19623624 chr10:135278901 LOC619207 -0.35 -5.75 -0.3 2.04e-8 Systemic lupus erythematosus; CRC cis rs765787 0.530 rs1706832 chr15:45517173 C/T cg24006582 chr15:45444508 DUOX1 -0.58 -8.78 -0.44 8.99e-17 Uric acid levels; CRC trans rs10983614 1.000 rs7867776 chr9:120072627 A/G cg06391300 chr11:119600292 PVRL1 0.46 6.21 0.32 1.64e-9 Survival in pancreatic cancer; CRC cis rs12368653 1.000 rs12368653 chr12:58133256 A/G cg00700412 chr12:58011837 NA -0.37 -5.7 -0.3 2.62e-8 Multiple sclerosis; CRC cis rs995000 0.931 rs1184547 chr1:63007228 G/A cg19896129 chr1:63156450 NA -0.44 -6.81 -0.35 4.6e-11 Triglyceride levels; CRC cis rs11958404 1.000 rs72816538 chr5:157414303 A/G cg05962755 chr5:157440814 NA 0.74 10.37 0.5 5.47e-22 IgG glycosylation; CRC cis rs10193935 0.786 rs10178087 chr2:42409631 C/A cg27598129 chr2:42591480 NA -0.67 -7.77 -0.39 9.88e-14 Colonoscopy-negative controls vs population controls; CRC cis rs970548 0.954 rs61854123 chr10:46065451 G/A cg15590007 chr10:45870220 ALOX5 0.49 6.26 0.33 1.19e-9 Total cholesterol levels;Cholesterol, total;HDL cholesterol;HDL cholesterol levels; CRC cis rs4478858 0.735 rs12404861 chr1:31861271 G/A cg00250761 chr1:31883323 NA -0.41 -7.51 -0.38 5.45e-13 Alcohol dependence; CRC trans rs1728785 0.901 rs1728787 chr16:68593042 G/C cg04657470 chr2:198365150 HSPE1;HSPD1 0.59 7.14 0.37 5.95e-12 Ulcerative colitis; CRC cis rs754466 0.606 rs11002315 chr10:79617385 T/G cg26805224 chr10:79626177 DLG5 -0.56 -8.34 -0.42 2.12e-15 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs4819052 0.765 rs2838827 chr21:46656146 C/T cg19498844 chr21:46707878 POFUT2;LOC642852 0.73 10.11 0.49 4.34e-21 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs2153535 0.542 rs4440510 chr6:8471818 C/T cg07606381 chr6:8435919 SLC35B3 0.69 11.0 0.52 3.47e-24 Motion sickness; CRC cis rs727563 0.648 rs6002406 chr22:41965237 A/T cg06634786 chr22:41940651 POLR3H -0.66 -7.03 -0.36 1.22e-11 Crohn's disease;Inflammatory bowel disease; CRC cis rs5750830 0.621 rs5757665 chr22:39821641 A/G cg24399712 chr22:39784796 NA -0.47 -8.86 -0.44 5.06e-17 Intelligence (multi-trait analysis); CRC cis rs9322193 0.923 rs4869750 chr6:150177132 C/T cg05861140 chr6:150128134 PCMT1 -0.46 -7.65 -0.39 2.29e-13 Lung cancer; CRC cis rs2249694 1.000 rs2515644 chr10:135353079 A/C cg20169779 chr10:135381914 SYCE1 0.54 8.67 0.43 1.93e-16 Obesity-related traits; CRC cis rs713587 0.607 rs6725517 chr2:25129473 A/G cg22495460 chr2:25135724 ADCY3 -0.9 -18.29 -0.71 4.54e-52 Body mass index in non-asthmatics; CRC trans rs9650657 0.529 rs10108618 chr8:10953092 A/G cg16141378 chr3:129829833 LOC729375 0.46 6.97 0.36 1.72e-11 Neuroticism; CRC cis rs6951245 0.507 rs11976805 chr7:1138716 C/T cg24642844 chr7:1081250 C7orf50 -0.41 -5.62 -0.3 4.15e-8 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs6912958 0.781 rs4464759 chr6:88282621 A/C cg08069147 chr6:88032118 GJB7;C6orf162 -0.57 -8.57 -0.43 4.19e-16 Monocyte percentage of white cells; CRC cis rs4975616 0.869 rs421284 chr5:1325590 T/C cg26373071 chr5:1325741 CLPTM1L 0.54 9.97 0.48 1.27e-20 Lung cancer; CRC cis rs12348691 0.503 rs4743138 chr9:100614296 C/T cg13688889 chr9:100608707 NA 0.48 6.18 0.32 1.86e-9 Alopecia areata; CRC cis rs6500395 1.000 rs7184144 chr16:48606077 C/T cg04672837 chr16:48644449 N4BP1 0.45 6.66 0.34 1.17e-10 Response to tocilizumab in rheumatoid arthritis; CRC cis rs2985684 1.000 rs2147712 chr14:50091684 G/A cg04989706 chr14:50066350 PPIL5 -0.54 -7.47 -0.38 7.5e-13 Carotid intima media thickness; CRC cis rs1124376 0.935 rs67660889 chr3:20170538 G/C cg05072819 chr3:20081367 KAT2B 0.49 5.64 0.3 3.74e-8 Bipolar disorder and schizophrenia; CRC cis rs9814567 1.000 rs11927068 chr3:134266321 A/G cg06109529 chr3:134205091 CEP63;ANAPC13 0.82 12.06 0.55 5.69e-28 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs13256369 0.826 rs12678414 chr8:8586016 G/T cg18904891 chr8:8559673 CLDN23 0.54 7.53 0.38 4.98e-13 Obesity-related traits; CRC cis rs2032447 0.507 rs478349 chr6:25894057 T/C cg03264133 chr6:25882463 NA -0.79 -10.82 -0.51 1.52e-23 Intelligence (multi-trait analysis); CRC cis rs1322512 0.920 rs1744378 chr6:152943176 T/C cg03415253 chr6:152958462 SYNE1 -0.43 -6.84 -0.35 3.88e-11 Tonometry; CRC cis rs9311474 0.632 rs6445528 chr3:52572447 C/T cg08222913 chr3:52553049 STAB1 0.38 7.34 0.38 1.66e-12 Electroencephalogram traits; CRC cis rs1448094 0.511 rs7968059 chr12:86163606 A/G cg00310523 chr12:86230176 RASSF9 0.38 6.15 0.32 2.2e-9 Major depressive disorder; CRC cis rs9488822 0.702 rs6909746 chr6:116352750 C/T cg26893134 chr6:116381904 FRK 0.27 7.98 0.4 2.46e-14 Cholesterol, total;LDL cholesterol; CRC cis rs56399783 0.901 rs6964740 chr7:2819656 C/G cg19731401 chr7:2775893 GNA12 0.55 6.4 0.33 5.3e-10 Childhood ear infection; CRC cis rs8060686 0.641 rs7199588 chr16:68224582 C/T cg08314208 chr16:67682810 RLTPR -0.49 -5.88 -0.31 9.81e-9 HDL cholesterol;Metabolic syndrome; CRC cis rs7762018 0.769 rs7766146 chr6:170070135 A/T cg19338460 chr6:170058176 WDR27 -0.88 -8.89 -0.44 4.03e-17 Thiazide-induced adverse metabolic effects in hypertensive patients; CRC cis rs6586163 1.000 rs1926196 chr10:90753748 C/T cg03111039 chr10:90751583 FAS;ACTA2 0.5 7.26 0.37 2.83e-12 Chronic lymphocytic leukemia; CRC cis rs6952808 0.601 rs3778978 chr7:2159817 A/G cg22963979 chr7:1858916 MAD1L1 -0.45 -6.42 -0.33 4.67e-10 Bipolar disorder and schizophrenia; CRC cis rs9648428 0.515 rs11974488 chr7:36202112 G/T cg14708893 chr7:36124863 NA -0.41 -6.01 -0.31 4.8e-9 Obesity-related traits; CRC cis rs12410462 0.681 rs75876430 chr1:227661157 A/G cg23173402 chr1:227635558 NA 0.87 8.87 0.44 4.77e-17 Major depressive disorder; CRC cis rs11585357 1.000 rs72646785 chr1:17603472 G/T cg08277548 chr1:17600880 PADI3 -0.93 -11.65 -0.54 1.73e-26 Hair shape; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg14301165 chr19:53324198 ZNF28 0.42 6.76 0.35 6.46e-11 Liver disease severity in Alagille syndrome; CRC cis rs4664293 0.867 rs6760485 chr2:160579690 T/C cg08347373 chr2:160653686 CD302 -0.47 -7.43 -0.38 9.32e-13 Monocyte percentage of white cells; CRC cis rs1862618 0.853 rs2432195 chr5:56120413 C/T cg20203395 chr5:56204925 C5orf35 -0.66 -7.94 -0.4 3.13e-14 Initial pursuit acceleration; CRC cis rs73206853 0.841 rs16940933 chr12:111102574 C/A cg12870014 chr12:110450643 ANKRD13A 0.79 8.35 0.42 1.94e-15 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC cis rs4713118 0.738 rs200465 chr6:27757654 T/A cg15786705 chr6:28176104 NA 0.53 6.92 0.36 2.32e-11 Parkinson's disease; CRC cis rs10876993 0.855 rs1689604 chr12:58048304 T/C cg15848620 chr12:58087721 OS9 -0.64 -8.86 -0.44 5.12e-17 Celiac disease or Rheumatoid arthritis; CRC cis rs67340775 0.541 rs169287 chr6:27854760 C/A cg02683197 chr6:28174875 NA 0.66 6.56 0.34 2.06e-10 Lung cancer in ever smokers; CRC cis rs2832191 0.720 rs7277028 chr21:30494604 T/C cg08807101 chr21:30365312 RNF160 -0.63 -9.93 -0.48 1.74e-20 Dental caries; CRC cis rs1552244 1.000 rs7615646 chr3:10089773 A/C cg02579736 chr3:10068473 FANCD2;CIDECP 1.02 13.77 0.6 2.25e-34 Alzheimer's disease; CRC cis rs710216 0.536 rs710221 chr1:43414200 G/A cg03128534 chr1:43423976 SLC2A1 0.65 10.18 0.49 2.38e-21 Red cell distribution width; CRC cis rs1865760 0.929 rs9467646 chr6:25957408 A/G cg16482183 chr6:26056742 HIST1H1C 0.58 8.53 0.43 5.34e-16 Height; CRC cis rs4975616 0.773 rs10078017 chr5:1314009 C/T cg06550200 chr5:1325588 CLPTM1L 0.63 9.56 0.47 2.96e-19 Lung cancer; CRC cis rs2688608 0.592 rs3933085 chr10:75483331 C/T cg16540259 chr10:75572220 NDST2 0.38 6.0 0.31 5.25e-9 Inflammatory bowel disease; CRC cis rs9914988 0.943 rs4794836 chr17:27082710 C/G cg20469991 chr17:27169893 C17orf63 0.47 6.01 0.31 4.85e-9 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs9549328 0.542 rs36172983 chr13:113616582 T/C cg17524180 chr13:113633600 MCF2L 0.52 9.39 0.46 1e-18 Systolic blood pressure; CRC cis rs8044868 0.530 rs2287998 chr16:72059269 C/T cg06172871 chr16:72088244 HP -0.39 -5.76 -0.3 1.95e-8 Body mass index (change over time) in cancer or chronic obstructive pulmonary disease;Body mass index (change over time) in cancer; CRC cis rs1799949 1.000 rs11649954 chr17:41420035 A/G cg25072359 chr17:41440525 NA 0.46 6.91 0.36 2.59e-11 Menopause (age at onset); CRC cis rs7224737 0.956 rs8081900 chr17:40289875 G/A cg00647820 chr17:40259828 DHX58 -0.46 -6.49 -0.34 3.13e-10 Fibrinogen levels; CRC cis rs1448094 0.511 rs2405616 chr12:86148042 A/G cg02569458 chr12:86230093 RASSF9 -0.48 -8.08 -0.41 1.27e-14 Major depressive disorder; CRC cis rs4938330 0.608 rs3882897 chr11:117091227 G/A cg01368799 chr11:117014884 PAFAH1B2 -0.47 -5.98 -0.31 5.71e-9 Blood protein levels; CRC cis rs10504229 0.593 rs11781042 chr8:57993056 A/T cg21724239 chr8:58056113 NA 0.57 7.34 0.38 1.66e-12 Developmental language disorder (linguistic errors); CRC cis rs2243480 1.000 rs10247526 chr7:65780696 T/G cg12463550 chr7:65579703 CRCP -0.7 -6.28 -0.33 1.08e-9 Diabetic kidney disease; CRC cis rs853679 0.517 rs1947863 chr6:28099344 G/A cg23161317 chr6:28129485 ZNF389 0.53 6.54 0.34 2.37e-10 Depression; CRC cis rs12541635 0.966 rs12674846 chr8:107007178 A/G cg10147462 chr8:107024639 NA 0.42 6.92 0.36 2.42e-11 Age of smoking initiation; CRC cis rs6918586 0.658 rs198844 chr6:26108282 C/G cg18357526 chr6:26021779 HIST1H4A -0.47 -6.94 -0.36 2.1e-11 Schizophrenia; CRC cis rs7726839 0.540 rs61580655 chr5:597564 A/G cg14541582 chr5:601475 NA -0.35 -7.25 -0.37 3.02e-12 Obesity-related traits; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg14988214 chr2:8977332 KIDINS220 0.47 6.66 0.34 1.17e-10 Response to antipsychotic treatment; CRC cis rs77861329 1.000 rs9843852 chr3:52132029 C/G cg08692210 chr3:52188851 WDR51A 0.88 8.41 0.42 1.29e-15 Macrophage inflammatory protein 1b levels; CRC cis rs992157 0.661 rs10171839 chr2:219051314 C/T cg04731861 chr2:219085781 ARPC2 -0.32 -6.72 -0.35 8.07e-11 Colorectal cancer; CRC trans rs1367248 1.000 rs780039 chr2:125009650 A/G cg07402188 chr19:40720005 MAP3K10 -0.45 -6.09 -0.32 3.16e-9 Tonometry; CRC cis rs12188164 0.610 rs6555242 chr5:416546 A/C cg26850624 chr5:429559 AHRR -0.64 -10.48 -0.5 2.33e-22 Cystic fibrosis severity; CRC cis rs644799 0.710 rs3017756 chr11:95537358 G/A cg25478527 chr11:95522999 CEP57;FAM76B 0.48 7.52 0.38 5.35e-13 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs10197940 0.624 rs10497081 chr2:152353395 T/G cg06191203 chr2:152266755 RIF1 -0.72 -10.35 -0.5 6.44e-22 Lung cancer; CRC cis rs6973256 0.865 rs2483509 chr7:133341162 G/A cg10665199 chr7:133106180 EXOC4 -0.37 -5.65 -0.3 3.55e-8 Intelligence (multi-trait analysis); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg15680518 chr12:132414800 PUS1 0.44 6.51 0.34 2.86e-10 Response to antipsychotic treatment; CRC cis rs6570726 0.934 rs430003 chr6:145819506 C/T cg23711669 chr6:146136114 FBXO30 0.68 12.16 0.56 2.33e-28 Lobe attachment (rater-scored or self-reported); CRC cis rs2882667 0.858 rs11948429 chr5:138458584 G/A cg04439458 chr5:138467593 SIL1 -0.36 -6.04 -0.32 4.14e-9 Age-related hearing impairment (SNP x SNP interaction); CRC trans rs1814175 0.645 rs10839448 chr11:49938930 G/A cg21153622 chr11:89784906 NA -0.39 -6.08 -0.32 3.33e-9 Height; CRC cis rs6840360 1.000 rs2278304 chr4:152593409 C/T cg09659197 chr4:152720779 NA -0.5 -10.37 -0.5 5.34e-22 Intelligence (multi-trait analysis); CRC cis rs7647973 0.593 rs4855885 chr3:49690199 G/A cg03060546 chr3:49711283 APEH 0.65 7.32 0.37 1.91e-12 Menarche (age at onset); CRC cis rs2576037 0.583 rs9954336 chr18:44465945 A/G cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.56 -8.69 -0.43 1.79e-16 Personality dimensions; CRC cis rs6433857 0.594 rs11894486 chr2:181520678 C/T cg23363182 chr2:181467187 NA -0.47 -7.28 -0.37 2.5e-12 Body mass index; CRC trans rs6600671 1.000 rs4844616 chr1:121171208 A/G cg00646200 chr1:148855367 NA 0.34 6.15 0.32 2.22e-9 Hip geometry; CRC cis rs929354 0.742 rs7807556 chr7:156934329 T/C cg05182265 chr7:156933206 UBE3C -0.73 -13.35 -0.59 8.95e-33 Body mass index; CRC cis rs8180040 0.726 rs13094672 chr3:47149439 C/T cg27129171 chr3:47204927 SETD2 0.68 10.91 0.52 7.16e-24 Colorectal cancer; CRC cis rs2153535 0.584 rs55945625 chr6:8371367 C/T cg07606381 chr6:8435919 SLC35B3 -0.64 -9.92 -0.48 1.82e-20 Motion sickness; CRC cis rs6951245 1.000 rs113858334 chr7:1073476 A/G cg24642844 chr7:1081250 C7orf50 -0.78 -9.35 -0.46 1.42e-18 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs10504229 0.728 rs17804822 chr8:58156276 T/C cg02725872 chr8:58115012 NA -0.59 -9.19 -0.45 4.62e-18 Developmental language disorder (linguistic errors); CRC cis rs9359856 0.636 rs1980878 chr6:90314749 A/C cg13799429 chr6:90582589 CASP8AP2 0.59 7.88 0.4 4.77e-14 Bipolar disorder; CRC cis rs10986311 0.802 rs1330811 chr9:127117346 G/A cg14243010 chr9:127117328 LOC100129034;PSMB7 0.4 6.03 0.32 4.44e-9 Vitiligo; CRC cis rs12762955 0.561 rs4880744 chr10:1012026 A/G cg20503657 chr10:835505 NA -0.44 -6.1 -0.32 3.04e-9 Response to angiotensin II receptor blocker therapy; CRC cis rs7618915 0.571 rs67539070 chr3:52711974 T/C cg11645453 chr3:52864694 ITIH4 0.35 6.14 0.32 2.31e-9 Bipolar disorder; CRC cis rs4689388 0.926 rs10012946 chr4:6293350 C/T cg00701064 chr4:6280414 WFS1 -0.75 -12.23 -0.56 1.3e-28 Type 2 diabetes and other traits;Type 2 diabetes; CRC cis rs597539 0.690 rs647661 chr11:68625875 T/C cg21963583 chr11:68658836 MRPL21 0.59 10.38 0.5 5.06e-22 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs6089584 0.853 rs1746280 chr20:60577821 C/G cg18761221 chr20:60518478 NA 0.53 8.59 0.43 3.47e-16 Body mass index; CRC cis rs11264799 0.598 rs79853736 chr1:157732091 A/C cg11810135 chr1:157771971 FCRL1 0.4 5.96 0.31 6.5e-9 IgA nephropathy; CRC cis rs10504229 0.728 rs17215676 chr8:58152915 G/T cg11062466 chr8:58055876 NA 0.45 6.11 0.32 2.74e-9 Developmental language disorder (linguistic errors); CRC cis rs6951245 1.000 rs78185558 chr7:1090183 G/C cg22907277 chr7:1156413 C7orf50 0.66 7.13 0.37 6.47e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs7107174 1.000 rs2510051 chr11:77981171 A/C cg02023728 chr11:77925099 USP35 0.53 8.17 0.41 6.81e-15 Testicular germ cell tumor; CRC cis rs2576037 0.583 rs487386 chr18:44377004 A/G cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.56 -8.51 -0.42 6.15e-16 Personality dimensions; CRC cis rs7923609 0.902 rs7897379 chr10:65301725 T/C cg08743896 chr10:65200160 JMJD1C -0.42 -5.9 -0.31 9.12e-9 Educational attainment;Liver enzyme levels (alkaline phosphatase); CRC cis rs8177253 0.665 rs7646118 chr3:133450039 C/T cg01448562 chr3:133502909 NA -0.39 -6.25 -0.33 1.28e-9 Iron status biomarkers; CRC trans rs2303319 0.504 rs12473497 chr2:162433766 T/C cg14875682 chr5:52083620 ITGA1;PELO -0.77 -6.19 -0.32 1.79e-9 Cognitive function; CRC cis rs6496667 0.779 rs7169787 chr15:91039929 C/T cg04176472 chr15:90893244 GABARAPL3 0.57 7.64 0.39 2.44e-13 Rheumatoid arthritis; CRC cis rs28386778 0.863 rs7221573 chr17:61859390 G/A cg22520471 chr17:61851767 DDX42;CCDC47 0.75 11.73 0.54 8.92e-27 Prudent dietary pattern; CRC cis rs2243480 1.000 rs160648 chr7:65543384 C/A cg18252515 chr7:66147081 NA -1.13 -13.34 -0.59 9.36e-33 Diabetic kidney disease; CRC cis rs2811415 0.597 rs9809497 chr3:127782514 T/C cg13719885 chr3:127795394 NA -0.39 -5.98 -0.31 5.94e-9 Lung function (FEV1/FVC); CRC cis rs2228479 0.850 rs1800331 chr16:89858417 C/A cg06558623 chr16:89946397 TCF25 1.17 11.65 0.54 1.69e-26 Skin colour saturation; CRC cis rs72781680 0.898 rs12612492 chr2:24093756 C/T cg08917208 chr2:24149416 ATAD2B 0.95 10.37 0.5 5.63e-22 Lymphocyte counts; CRC cis rs9549260 0.567 rs7332730 chr13:41265979 C/A cg21288729 chr13:41239152 FOXO1 0.43 6.63 0.34 1.38e-10 Red blood cell count; CRC cis rs4319547 0.956 rs7316149 chr12:123063912 G/A cg05707623 chr12:122985044 ZCCHC8 -0.75 -9.45 -0.46 6.39e-19 Body mass index; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg17356280 chr15:56657632 TEX9 0.37 6.2 0.32 1.7e-9 Liver disease severity in Alagille syndrome; CRC trans rs300489 0.887 rs1726005 chr12:78488999 A/C cg24901662 chr10:34977342 PARD3 0.36 6.0 0.31 5.34e-9 Self-rated health; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg22297934 chr17:76421671 DNAH17 -0.36 -6.21 -0.32 1.64e-9 Liver disease severity in Alagille syndrome; CRC cis rs2976388 0.524 rs7012804 chr8:143844650 A/G cg15511327 chr8:143859410 LYNX1 0.56 10.24 0.49 1.57e-21 Urinary tract infection frequency; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg01732804 chr2:220118692 TUBA4A;TUBA4B 0.43 6.33 0.33 8.07e-10 Response to antipsychotic treatment; CRC cis rs9323205 0.677 rs12589680 chr14:51723138 T/C cg23942311 chr14:51606299 NA -0.52 -6.19 -0.32 1.78e-9 Cancer; CRC cis rs2735413 0.874 rs12917942 chr16:78064220 T/G cg04733911 chr16:78082701 NA -0.37 -6.0 -0.31 5.14e-9 Systolic blood pressure (alcohol consumption interaction); CRC cis rs8141797 0.748 rs6004050 chr22:24461944 A/G cg20894457 chr22:24584366 SUSD2 -0.61 -7.43 -0.38 9.27e-13 Amyotrophic lateral sclerosis;Coronary artery disease; CRC cis rs2404602 0.692 rs8024476 chr15:76983954 T/C cg23625390 chr15:77176239 SCAPER 0.5 7.36 0.38 1.5e-12 Blood metabolite levels; CRC cis rs2985684 1.000 rs11157696 chr14:50105746 C/G cg10008539 chr14:50087325 RPL36AL;MGAT2 0.43 6.03 0.32 4.39e-9 Carotid intima media thickness; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg16136840 chr5:95997740 CAST 0.41 7.04 0.36 1.15e-11 Liver disease severity in Alagille syndrome; CRC trans rs4332037 1.000 rs10240470 chr7:1949971 G/T cg11693508 chr17:37793320 STARD3 -0.61 -7.56 -0.38 4.13e-13 Bipolar disorder; CRC cis rs7647973 1.000 rs3870339 chr3:49536863 T/A cg07636037 chr3:49044803 WDR6 0.66 8.1 0.41 1.1e-14 Menarche (age at onset); CRC cis rs1552244 0.935 rs35148833 chr3:10116937 C/A cg00166722 chr3:10149974 C3orf24 0.7 9.53 0.46 3.69e-19 Alzheimer's disease; CRC cis rs881375 0.967 rs1008382 chr9:123681255 C/G cg00246817 chr9:123691163 NA -0.44 -5.7 -0.3 2.62e-8 Rheumatoid arthritis; CRC cis rs736408 0.648 rs3774355 chr3:52817778 G/A cg10802521 chr3:52805072 NEK4 -0.57 -8.21 -0.41 4.98e-15 Bipolar disorder; CRC cis rs12048904 0.964 rs12027668 chr1:101330984 G/A cg16556008 chr1:101360663 SLC30A7;EXTL2 0.62 9.31 0.46 1.89e-18 Multiple sclerosis; CRC cis rs360798 0.553 rs11682530 chr2:63073194 C/T cg17519650 chr2:63277830 OTX1 -0.44 -6.4 -0.33 5.34e-10 Coronary artery disease; CRC cis rs4665809 0.590 rs7579504 chr2:26439995 T/C cg22920501 chr2:26401640 FAM59B -0.83 -11.96 -0.55 1.28e-27 Gut microbiome composition (summer); CRC cis rs17270561 0.609 rs4712963 chr6:25740502 C/T cg17691542 chr6:26056736 HIST1H1C 0.73 9.22 0.45 3.68e-18 Iron status biomarkers; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg10554839 chr10:27529782 ACBD5 0.42 5.97 0.31 6.22e-9 Anxiety disorder; CRC cis rs889312 0.500 rs832570 chr5:56156408 G/A cg12311346 chr5:56204834 C5orf35 -0.45 -6.8 -0.35 5.01e-11 Breast cancer;Breast cancer (early onset); CRC cis rs12580194 0.593 rs61556775 chr12:55745640 A/C cg23425280 chr12:56401806 NA 0.47 5.72 0.3 2.44e-8 Cancer; CRC cis rs3749237 0.595 rs1464567 chr3:49459252 C/G cg02487422 chr3:49467188 NICN1 -0.43 -7.05 -0.36 1.03e-11 Resting heart rate; CRC cis rs11190604 1.000 rs7088512 chr10:102303498 G/T cg07080220 chr10:102295463 HIF1AN 0.49 6.33 0.33 7.83e-10 Palmitoleic acid (16:1n-7) levels; CRC cis rs6061231 0.724 rs1570027 chr20:60968596 A/G cg22601191 chr20:60968625 CABLES2 0.55 9.03 0.45 1.48e-17 Colorectal cancer; CRC cis rs12541635 0.966 rs114386112 chr8:107036340 G/A cg10147462 chr8:107024639 NA 0.46 7.56 0.38 4.04e-13 Age of smoking initiation; CRC cis rs1862618 0.853 rs832568 chr5:56153776 G/A cg12311346 chr5:56204834 C5orf35 -0.8 -10.27 -0.49 1.24e-21 Initial pursuit acceleration; CRC cis rs904251 1.000 rs12212090 chr6:37431808 A/G cg25019722 chr6:37503610 NA -0.37 -6.56 -0.34 2.06e-10 Cognitive performance; CRC cis rs13118159 0.550 rs2336081 chr4:1350322 A/G cg16405210 chr4:1374714 KIAA1530 0.9 14.08 0.61 1.43e-35 Longevity; CRC cis rs17376456 0.877 rs66696214 chr5:93424533 G/A cg09848695 chr5:92956644 FAM172A;MIR2277 0.65 6.03 0.32 4.38e-9 Diabetic retinopathy; CRC cis rs2836950 0.561 rs34705151 chr21:40553344 G/A cg11644478 chr21:40555479 PSMG1 -0.49 -7.39 -0.38 1.19e-12 Menarche (age at onset); CRC cis rs116095464 0.614 rs62344339 chr5:252995 T/G cg22496380 chr5:211416 CCDC127 -0.91 -10.46 -0.5 2.65e-22 Breast cancer; CRC cis rs17376456 0.825 rs10038828 chr5:93124056 C/T cg21475434 chr5:93447410 FAM172A 0.71 6.79 0.35 5.34e-11 Diabetic retinopathy; CRC cis rs12220238 0.915 rs75467340 chr10:75907318 C/T cg19889307 chr10:75911429 ADK;AP3M1 0.61 5.7 0.3 2.69e-8 Soluble interleukin-2 receptor subunit alpha; CRC cis rs7584330 0.554 rs3751111 chr2:238426953 G/T cg08992911 chr2:238395768 MLPH 0.47 5.75 0.3 2.04e-8 Prostate cancer; CRC cis rs7429990 0.864 rs4858863 chr3:47855633 A/G cg11946769 chr3:48343235 NME6 -0.46 -5.83 -0.31 1.29e-8 Educational attainment (years of education); CRC cis rs2303759 0.874 rs8108669 chr19:49845895 C/T cg22590775 chr19:49891494 CCDC155 0.61 8.72 0.43 1.45e-16 Multiple sclerosis; CRC cis rs3806843 1.000 rs6898906 chr5:140169299 C/G cg16607685 chr5:140181889 PCDHA2;PCDHA1;PCDHA3 -0.26 -5.92 -0.31 8.09e-9 Depressive symptoms (multi-trait analysis); CRC cis rs11098499 0.863 rs7657849 chr4:120455494 T/C cg09307838 chr4:120376055 NA 0.69 10.34 0.5 6.68e-22 Corneal astigmatism; CRC cis rs7208859 0.623 rs9899692 chr17:29156939 C/T cg01831904 chr17:28903510 LRRC37B2 -0.61 -6.43 -0.33 4.58e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs9322193 0.886 rs17672976 chr6:150097343 T/A cg05861140 chr6:150128134 PCMT1 -0.43 -7.05 -0.36 1.03e-11 Lung cancer; CRC cis rs6570726 0.935 rs446242 chr6:145843866 A/G cg05347473 chr6:146136440 FBXO30 0.37 5.88 0.31 1.01e-8 Lobe attachment (rater-scored or self-reported); CRC trans rs1814175 0.645 rs10444311 chr11:49986906 A/G cg15704280 chr7:45808275 SEPT13 -0.94 -16.88 -0.68 1.75e-46 Height; CRC cis rs7945705 0.934 rs1988709 chr11:8882890 A/T cg00186954 chr11:8933980 ST5;C11orf17 0.46 7.19 0.37 4.43e-12 Hemoglobin concentration; CRC cis rs9443645 0.901 rs9343844 chr6:79586463 T/A cg11833968 chr6:79620685 NA -0.37 -6.48 -0.34 3.34e-10 Intelligence (multi-trait analysis); CRC cis rs1862618 0.511 rs2591952 chr5:56120769 T/A cg20203395 chr5:56204925 C5orf35 -0.65 -7.84 -0.4 6.36e-14 Initial pursuit acceleration; CRC cis rs12431939 0.626 rs10138856 chr14:51712712 G/A cg23942311 chr14:51606299 NA 0.5 6.55 0.34 2.16e-10 Cancer; CRC cis rs10504229 0.906 rs73607868 chr8:58172482 T/C cg01721255 chr8:58191610 C8orf71 0.49 6.17 0.32 2e-9 Developmental language disorder (linguistic errors); CRC cis rs943466 0.513 rs755497 chr6:33734419 C/T cg25922239 chr6:33757077 LEMD2 -0.44 -6.62 -0.34 1.43e-10 Body mass index (joint analysis main effects and physical activity interaction);Body mass index; CRC cis rs9372498 0.536 rs28605789 chr6:118889952 G/A cg24463073 chr6:118973353 C6orf204 0.52 6.83 0.35 4.1e-11 Diastolic blood pressure; CRC cis rs62458065 0.713 rs921406 chr7:32486205 G/C cg20159608 chr7:32802032 NA -0.59 -7.37 -0.38 1.36e-12 Metabolite levels (HVA/MHPG ratio); CRC cis rs7213347 0.707 rs216182 chr17:2173063 A/G cg15816464 chr17:2026533 SMG6 -0.37 -6.12 -0.32 2.62e-9 Total body bone mineral density; CRC trans rs1005277 0.691 rs2474558 chr10:38486141 A/C cg17830980 chr10:43048298 ZNF37B 0.5 7.68 0.39 1.89e-13 Extrinsic epigenetic age acceleration; CRC cis rs2243480 1.000 rs2961102 chr7:65424658 A/G cg18252515 chr7:66147081 NA -1.08 -12.37 -0.56 4.09e-29 Diabetic kidney disease; CRC cis rs6951245 0.554 rs10246354 chr7:1132456 C/T cg18297960 chr7:1142765 C7orf50 -0.46 -6.33 -0.33 8.18e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC trans rs916888 0.773 rs199535 chr17:44822662 A/G cg10053473 chr17:62856997 LRRC37A3 -0.76 -8.5 -0.42 6.66e-16 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs13108904 0.557 rs1680030 chr4:1245500 A/T cg21620606 chr4:1342894 KIAA1530 -0.45 -7.16 -0.37 5.26e-12 Obesity-related traits; CRC cis rs9875589 0.509 rs7651599 chr3:14010974 C/G cg14375111 chr3:14165186 TMEM43;CHCHD4 0.44 6.79 0.35 5.29e-11 Ovarian reserve; CRC cis rs3087591 0.683 rs17826544 chr17:29640225 A/G cg24425628 chr17:29625626 OMG;NF1 0.74 13.32 0.59 1.13e-32 Hip circumference; CRC cis rs4243830 0.850 rs12744992 chr1:6601290 G/A cg22792644 chr1:6614718 TAS1R1;NOL9 -0.8 -9.66 -0.47 1.35e-19 Body mass index; CRC cis rs12681288 0.578 rs10503154 chr8:969343 C/G cg08648136 chr8:956695 NA 0.34 6.14 0.32 2.34e-9 Schizophrenia; CRC cis rs3096299 0.509 rs4785691 chr16:89597221 A/G cg02187348 chr16:89574699 SPG7 0.45 6.66 0.34 1.13e-10 Multiple myeloma (IgH translocation); CRC cis rs7727544 1.000 rs7727544 chr5:131590534 C/T cg18758796 chr5:131593413 PDLIM4 0.34 6.38 0.33 5.87e-10 Blood metabolite levels; CRC trans rs853679 0.760 rs11967137 chr6:28199764 A/G cg06606381 chr12:133084897 FBRSL1 -0.65 -6.65 -0.34 1.22e-10 Depression; CRC trans rs11098499 0.754 rs7672778 chr4:120248585 A/G cg25214090 chr10:38739885 LOC399744 0.53 8.36 0.42 1.78e-15 Corneal astigmatism; CRC cis rs250677 0.652 rs1422582 chr5:148436925 T/C cg23229984 chr5:148520753 ABLIM3 0.55 7.09 0.36 8.21e-12 Breast cancer; CRC cis rs1799949 0.965 rs2236762 chr17:41226675 A/T cg05368731 chr17:41323189 NBR1 0.64 9.72 0.47 8.18e-20 Menopause (age at onset); CRC cis rs9487051 0.768 rs463503 chr6:109525757 T/C cg01475377 chr6:109611718 NA -0.34 -5.98 -0.31 5.7e-9 Reticulocyte fraction of red cells; CRC cis rs886126 0.650 rs4766566 chr12:111706877 C/T cg10833066 chr12:111807467 FAM109A 0.42 6.09 0.32 3.22e-9 Coronary heart disease; CRC cis rs6502050 0.835 rs7503189 chr17:80099486 C/A cg09264619 chr17:80180166 NA -0.34 -5.81 -0.3 1.5e-8 Life satisfaction; CRC cis rs10751667 0.666 rs10902255 chr11:967268 T/C cg06064525 chr11:970664 AP2A2 -0.3 -6.11 -0.32 2.78e-9 Alzheimer's disease (late onset); CRC cis rs4253772 0.550 rs6007779 chr22:46678615 A/C cg09491104 chr22:46646882 C22orf40 -0.41 -6.35 -0.33 7e-10 LDL cholesterol;Cholesterol, total; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg02455064 chr1:233086327 C1orf57 0.47 6.47 0.34 3.59e-10 Anxiety disorder; CRC cis rs6500602 0.929 rs9926114 chr16:4478322 C/G cg14951292 chr16:4525986 HMOX2;NMRAL1 0.59 8.74 0.43 1.21e-16 Schizophrenia; CRC cis rs73200209 0.744 rs11614867 chr12:116658916 A/C cg01776926 chr12:116560359 MED13L -0.62 -7.16 -0.37 5.42e-12 Total body bone mineral density; CRC cis rs4713118 0.662 rs9357060 chr6:28024486 C/G cg15786705 chr6:28176104 NA 0.7 9.41 0.46 9.04e-19 Parkinson's disease; CRC cis rs116095464 0.558 rs2288457 chr5:231270 C/T cg22496380 chr5:211416 CCDC127 -0.86 -9.9 -0.48 2.13e-20 Breast cancer; CRC cis rs4481887 0.893 rs28787378 chr1:248504447 C/T cg13385794 chr1:248469461 NA 0.34 6.36 0.33 6.59e-10 Common traits (Other); CRC cis rs6088590 1.000 rs6087623 chr20:33317662 C/G cg24642439 chr20:33292090 TP53INP2 0.59 10.63 0.51 6.92e-23 Coronary artery disease; CRC trans rs7267979 0.714 rs6115107 chr20:25237390 A/G cg17903999 chr18:56338584 MALT1 -0.42 -6.71 -0.35 8.62e-11 Liver enzyme levels (alkaline phosphatase); CRC trans rs2727020 0.521 rs7126835 chr11:49594658 T/C cg03929089 chr4:120376271 NA -0.76 -10.24 -0.49 1.58e-21 Coronary artery disease; CRC cis rs7833790 1.000 rs7833790 chr8:82731157 T/C cg27398817 chr8:82754497 SNX16 -0.46 -5.8 -0.3 1.56e-8 Diastolic blood pressure; CRC cis rs1552244 0.935 rs7621551 chr3:10114205 C/T cg13047869 chr3:10149882 C3orf24 0.57 7.8 0.4 8.27e-14 Alzheimer's disease; CRC trans rs8073060 0.586 rs11080356 chr17:33895309 T/C cg19694781 chr19:47549865 TMEM160 1.03 14.7 0.63 5.85e-38 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; CRC cis rs1552244 0.572 rs113406084 chr3:10170190 T/C cg00166722 chr3:10149974 C3orf24 0.66 7.71 0.39 1.49e-13 Alzheimer's disease; CRC cis rs832540 0.931 rs832535 chr5:56213334 C/T cg24531977 chr5:56204891 C5orf35 -0.48 -7.43 -0.38 9.71e-13 Coronary artery disease; CRC cis rs12142240 0.698 rs1984490 chr1:46858734 C/T cg14993813 chr1:46806288 NSUN4 0.49 6.33 0.33 8.1e-10 Menopause (age at onset); CRC cis rs7937682 0.921 rs688354 chr11:111438762 A/G cg19812747 chr11:111475976 SIK2 -0.53 -8.33 -0.42 2.16e-15 Primary sclerosing cholangitis; CRC cis rs3796619 0.961 rs11732520 chr4:1074009 C/T cg11579758 chr4:1086637 RNF212 0.4 6.61 0.34 1.58e-10 Recombination rate (males); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg14489649 chr17:40021376 KLHL11 0.44 6.14 0.32 2.36e-9 Response to antipsychotic treatment; CRC cis rs7264396 0.790 rs2425083 chr20:34300456 C/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.63 -10.83 -0.51 1.42e-23 Total cholesterol levels; CRC cis rs11122272 0.638 rs2739514 chr1:231514806 G/A cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.49 -6.99 -0.36 1.49e-11 Hemoglobin concentration; CRC cis rs11764590 0.715 rs62444907 chr7:2083267 C/T cg24505167 chr7:1915268 MAD1L1 -0.41 -5.63 -0.3 3.93e-8 Neuroticism; CRC cis rs9393692 0.645 rs2179152 chr6:26325888 T/C cg13736514 chr6:26305472 NA -0.66 -11.52 -0.54 5.12e-26 Educational attainment; CRC trans rs8002861 0.664 rs9533686 chr13:44468494 A/G cg12856521 chr11:46389249 DGKZ 0.42 6.53 0.34 2.57e-10 Leprosy; CRC cis rs1707322 0.721 rs12037803 chr1:46156492 A/G cg06784218 chr1:46089804 CCDC17 0.66 12.38 0.56 3.81e-29 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs9311474 0.629 rs4282054 chr3:52566065 T/C cg08222913 chr3:52553049 STAB1 -0.43 -8.72 -0.43 1.43e-16 Electroencephalogram traits; CRC cis rs9611565 0.559 rs5758428 chr22:42106216 G/A cg06634786 chr22:41940651 POLR3H 0.64 7.29 0.37 2.34e-12 Vitiligo; CRC cis rs6951245 0.938 rs113642700 chr7:1105654 C/T cg24642844 chr7:1081250 C7orf50 -0.78 -9.32 -0.46 1.75e-18 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs7224685 0.501 rs4790168 chr17:4022457 T/C cg21851534 chr17:3907994 ZZEF1 -0.36 -6.03 -0.32 4.37e-9 Type 2 diabetes; CRC cis rs1348850 0.958 rs10497501 chr2:178462299 C/G cg22681709 chr2:178499509 PDE11A -0.33 -6.08 -0.32 3.37e-9 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs7772486 0.754 rs10872580 chr6:146140281 C/T cg13319975 chr6:146136371 FBXO30 0.47 7.13 0.37 6.27e-12 Lobe attachment (rater-scored or self-reported); CRC cis rs10463316 0.894 rs6579863 chr5:150761946 A/T cg03212797 chr5:150827313 SLC36A1 -0.5 -7.78 -0.39 9.41e-14 Metabolite levels (Pyroglutamine); CRC cis rs3806843 1.000 rs7732179 chr5:140199039 G/A cg16607685 chr5:140181889 PCDHA2;PCDHA1;PCDHA3 -0.25 -5.88 -0.31 1.01e-8 Depressive symptoms (multi-trait analysis); CRC cis rs6964587 1.000 rs7785971 chr7:91736794 T/A cg17063962 chr7:91808500 NA 0.83 14.44 0.62 5.96e-37 Breast cancer; CRC cis rs739401 0.611 rs2239900 chr11:3030992 C/T cg08508325 chr11:3079039 CARS -0.48 -8.97 -0.44 2.23e-17 Longevity; CRC cis rs4862750 0.872 rs7672831 chr4:187898882 C/T cg27532560 chr4:187881888 NA -0.58 -10.93 -0.52 6.25e-24 Lobe attachment (rater-scored or self-reported); CRC cis rs6546324 0.625 rs2902007 chr2:67795462 A/T cg15745817 chr2:67799979 NA -0.55 -9.43 -0.46 7.6e-19 Endometriosis; CRC cis rs4319547 0.956 rs10744275 chr12:123048618 A/G cg23029597 chr12:123009494 RSRC2 -0.62 -7.8 -0.39 8.46e-14 Body mass index; CRC cis rs72781680 1.000 rs72781643 chr2:24208746 G/A cg08917208 chr2:24149416 ATAD2B 0.9 9.14 0.45 6.83e-18 Lymphocyte counts; CRC cis rs394563 0.775 rs420430 chr6:149785539 T/G cg16235748 chr6:149772707 ZC3H12D -0.38 -6.53 -0.34 2.56e-10 Dupuytren's disease; CRC cis rs6860806 0.507 rs272868 chr5:131680751 C/G cg12564285 chr5:131593104 PDLIM4 0.44 7.45 0.38 8.46e-13 Breast cancer; CRC cis rs11212617 1.000 rs227092 chr11:108236783 G/T cg14761454 chr11:108092087 ATM;NPAT 0.43 6.5 0.34 2.99e-10 Response to metformin in type 2 diabetes (glycemic); CRC cis rs6585424 1.000 rs34162901 chr10:81946856 A/C cg05935833 chr10:81318306 SFTPA2 -0.47 -5.64 -0.3 3.6e-8 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs919433 0.857 rs36071109 chr2:198183191 C/A cg03934865 chr2:198174659 NA -0.43 -7.02 -0.36 1.25e-11 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC cis rs11059919 1 rs11059919 chr12:129289190 G/A cg21616243 chr12:129299702 MGC16384;SLC15A4 -0.67 -11.23 -0.53 5.27e-25 Systemic lupus erythematosus; CRC cis rs7647973 0.580 rs4955432 chr3:49266772 C/T cg20833759 chr3:49053208 WDR6;DALRD3 0.41 6.69 0.35 9.55e-11 Menarche (age at onset); CRC cis rs2303745 0.589 rs1864116 chr19:17393015 C/T cg02221750 chr19:17393354 ANKLE1 -0.43 -6.58 -0.34 1.82e-10 Systemic lupus erythematosus; CRC cis rs4631830 0.900 rs10763546 chr10:51536399 C/G cg16070123 chr10:51489643 NA -0.34 -5.83 -0.31 1.36e-8 Prostate-specific antigen levels; CRC cis rs10256972 0.516 rs12702081 chr7:1141528 T/C cg18765753 chr7:1198926 ZFAND2A -0.36 -6.18 -0.32 1.89e-9 Longevity;Endometriosis; CRC cis rs35883536 0.935 rs12409832 chr1:101107725 A/G cg14515779 chr1:101123966 NA -0.43 -8.3 -0.42 2.75e-15 Monocyte count; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg09166705 chr1:151170883 PIP5K1A 0.38 6.02 0.31 4.57e-9 Liver disease severity in Alagille syndrome; CRC cis rs9969804 0.846 rs12683776 chr9:95434401 G/A cg14631576 chr9:95140430 CENPP -0.31 -5.73 -0.3 2.3e-8 Height; CRC cis rs72781680 0.752 rs72780185 chr2:24003967 G/A cg08917208 chr2:24149416 ATAD2B 0.84 8.11 0.41 1e-14 Lymphocyte counts; CRC cis rs12497850 0.627 rs4974078 chr3:49009386 C/T cg03060546 chr3:49711283 APEH 0.54 8.84 0.44 5.76e-17 Parkinson's disease; CRC cis rs727505 1.000 rs7795943 chr7:124483796 C/A cg23710748 chr7:124431027 NA -0.8 -14.18 -0.62 5.87e-36 Lewy body disease; CRC cis rs1707322 0.896 rs946528 chr1:46485562 C/T cg03146154 chr1:46216737 IPP -0.5 -7.1 -0.36 7.58e-12 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg03599547 chr12:56123102 CD63 0.41 6.2 0.32 1.68e-9 Liver disease severity in Alagille syndrome; CRC trans rs1455244 0.700 rs7229302 chr18:11508904 G/T cg05792827 chr1:213224765 RPS6KC1 0.4 6.11 0.32 2.83e-9 Schizophrenia; CRC cis rs3820068 0.581 rs6692461 chr1:15928449 A/G cg24675056 chr1:15929824 NA 0.52 7.27 0.37 2.64e-12 Systolic blood pressure; CRC cis rs62400317 0.686 rs860741 chr6:44808435 G/A cg18551225 chr6:44695536 NA 0.39 5.69 0.3 2.87e-8 Total body bone mineral density; CRC cis rs780096 0.506 rs780100 chr2:27652153 G/T cg12648201 chr2:27665141 KRTCAP3 -0.31 -6.18 -0.32 1.89e-9 Total body bone mineral density; CRC trans rs7615952 0.546 rs2976733 chr3:125414138 T/C cg21747405 chr11:67723411 NA -0.56 -8.76 -0.43 1.08e-16 Blood pressure (smoking interaction); CRC cis rs832540 1.000 rs832540 chr5:56199202 G/A cg12311346 chr5:56204834 C5orf35 -0.46 -6.92 -0.36 2.42e-11 Coronary artery disease; CRC cis rs7666738 0.830 rs1426664 chr4:98988264 A/C cg05340658 chr4:99064831 C4orf37 0.6 9.41 0.46 8.57e-19 Colonoscopy-negative controls vs population controls; CRC cis rs2180341 1.000 rs6904520 chr6:127629802 T/C cg24812749 chr6:127587940 RNF146 0.95 13.71 0.6 3.81e-34 Breast cancer; CRC cis rs1050631 0.592 rs1785903 chr18:33711642 G/C cg25426722 chr18:33708991 SLC39A6;ELP2 0.38 5.85 0.31 1.18e-8 Esophageal squamous cell cancer (length of survival); CRC cis rs10751667 0.666 rs4074235 chr11:977511 C/G cg01483505 chr11:975446 AP2A2 0.46 7.66 0.39 2.11e-13 Alzheimer's disease (late onset); CRC cis rs1336900 0.544 rs10888386 chr1:150611957 A/G cg17724175 chr1:150552817 MCL1 -0.67 -10.91 -0.52 7.63e-24 Blood protein levels; CRC cis rs10504229 0.728 rs72650853 chr8:58151473 G/A cg11062466 chr8:58055876 NA 0.45 6.11 0.32 2.74e-9 Developmental language disorder (linguistic errors); CRC cis rs4862750 0.914 rs1346127 chr4:187876389 C/T cg07414643 chr4:187882934 NA -0.38 -6.61 -0.34 1.51e-10 Lobe attachment (rater-scored or self-reported); CRC cis rs2075371 0.933 rs432336 chr7:133949064 A/G cg02659138 chr7:134003124 SLC35B4 0.35 6.05 0.32 4.04e-9 Mean platelet volume; CRC cis rs244731 0.959 rs9313752 chr5:176645435 G/T cg17509989 chr5:176798049 RGS14 -0.68 -9.07 -0.45 1.13e-17 Urate levels in lean individuals; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg16595246 chr2:48009933 MSH6 0.37 6.22 0.32 1.48e-9 Liver disease severity in Alagille syndrome; CRC cis rs13392177 0.684 rs11682371 chr2:219079513 G/A cg00012203 chr2:219082015 ARPC2 -0.5 -7.32 -0.37 1.88e-12 Pyoderma gangrenosum in inflammatory bowel disease; CRC cis rs1862618 0.853 rs252910 chr5:56192983 G/A cg22800045 chr5:56110881 MAP3K1 0.62 6.51 0.34 2.76e-10 Initial pursuit acceleration; CRC cis rs13118159 0.550 rs28733902 chr4:1374789 A/G cg02475777 chr4:1388615 CRIPAK 0.53 6.87 0.35 3.17e-11 Longevity; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg05468351 chr5:21459598 LOC728411 0.55 7.15 0.37 5.59e-12 Thyroid stimulating hormone; CRC trans rs561341 1.000 rs117029332 chr17:30266085 C/G cg27661571 chr11:113659931 NA -0.97 -11.28 -0.53 3.75e-25 Hip circumference adjusted for BMI; CRC cis rs738322 0.967 rs2092180 chr22:38571563 A/G cg25457927 chr22:38595422 NA -0.35 -7.4 -0.38 1.13e-12 Cutaneous nevi; CRC cis rs2404602 0.583 rs12908334 chr15:76581592 C/T cg22467129 chr15:76604101 ETFA -0.47 -8.35 -0.42 1.89e-15 Blood metabolite levels; CRC cis rs2882667 0.898 rs13163536 chr5:138377219 A/G cg09476006 chr5:138032270 NA 0.44 7.31 0.37 2.05e-12 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs10504229 0.683 rs56204590 chr8:58131642 T/G cg24829409 chr8:58192753 C8orf71 -0.55 -8.03 -0.4 1.71e-14 Developmental language disorder (linguistic errors); CRC cis rs13191362 0.507 rs13210000 chr6:163176944 G/A cg06582575 chr6:163149167 PACRG;PARK2 0.49 7.9 0.4 4.26e-14 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs10883723 0.810 rs7912901 chr10:104277440 T/C cg04362960 chr10:104952993 NT5C2 -0.42 -5.9 -0.31 8.92e-9 Allergic disease (asthma, hay fever or eczema); CRC cis rs1862618 0.853 rs6450408 chr5:56098146 T/C cg18230493 chr5:56204884 C5orf35 -0.75 -9.59 -0.47 2.26e-19 Initial pursuit acceleration; CRC cis rs60843830 1.000 rs2290911 chr2:224919 A/G cg00108164 chr2:264199 ACP1;SH3YL1 0.64 9.86 0.48 2.95e-20 Spherical equivalent (joint analysis main effects and education interaction); CRC trans rs6600671 0.967 rs4844613 chr1:121173773 T/C cg00646200 chr1:148855367 NA 0.33 5.98 0.31 5.77e-9 Hip geometry; CRC cis rs7223966 1.000 rs13380863 chr17:61780793 G/A cg23090583 chr17:61904693 PSMC5;FTSJ3 0.56 6.78 0.35 5.42e-11 Hip circumference adjusted for BMI;Body mass index; CRC trans rs2018683 0.624 rs2286219 chr7:28998663 G/A cg19402173 chr7:128379420 CALU -0.52 -7.78 -0.39 9.39e-14 Response to irinotecan and platinum-based chemotherapy in non-small-cell lung cancer; CRC cis rs9914988 0.943 rs9898892 chr17:27150750 T/C cg20469991 chr17:27169893 C17orf63 -0.59 -7.19 -0.37 4.48e-12 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs11958404 0.932 rs11949394 chr5:157425198 A/G cg05962755 chr5:157440814 NA 0.83 11.21 0.53 6.62e-25 IgG glycosylation; CRC cis rs4665809 0.590 rs10179959 chr2:26426403 G/A cg22920501 chr2:26401640 FAM59B -0.84 -12.0 -0.55 9.19e-28 Gut microbiome composition (summer); CRC cis rs6912958 0.559 rs242270 chr6:88062190 C/G cg08069147 chr6:88032118 GJB7;C6orf162 -0.68 -11.11 -0.52 1.49e-24 Monocyte percentage of white cells; CRC cis rs3751196 0.708 rs12423929 chr12:104146343 G/A cg02344784 chr12:104178138 NT5DC3 0.66 6.31 0.33 9.18e-10 Sense of smell; CRC cis rs3736594 0.513 rs76013440 chr2:27816315 G/A cg27432699 chr2:27873401 GPN1 0.65 7.97 0.4 2.7e-14 Fasting blood glucose;Fasting blood glucose (BMI interaction); CRC cis rs10832963 0.847 rs4237722 chr11:18639363 T/C cg09201001 chr11:18656081 SPTY2D1 0.77 12.14 0.56 2.87e-28 Breast cancer; CRC cis rs780096 0.526 rs11126999 chr2:27670307 G/A cg02592271 chr2:27665507 KRTCAP3 -0.27 -6.04 -0.32 4.26e-9 Total body bone mineral density; CRC trans rs7619427 0.544 rs9809968 chr3:44042297 A/T cg09408571 chr1:101003634 GPR88 0.45 6.27 0.33 1.12e-9 Schizophrenia; CRC cis rs9788721 0.836 rs2568494 chr15:78740964 G/A cg18825076 chr15:78729989 IREB2 -0.46 -7.22 -0.37 3.72e-12 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio;Emphysema imaging phenotypes;Emphysema distribution in smoking;Local histogram emphysema pattern;Post bronchodilator FEV1/FVC ratio in COPD; CRC cis rs9322193 0.923 rs4455682 chr6:150021297 C/T cg13206674 chr6:150067644 NUP43 0.65 9.75 0.47 6.68e-20 Lung cancer; CRC cis rs7568458 0.811 rs1446668 chr2:85764960 G/T cg02493740 chr2:85810744 VAMP5 -0.4 -6.49 -0.34 3.16e-10 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); CRC cis rs4237845 0.611 rs10877036 chr12:58321650 A/G cg00677455 chr12:58241039 CTDSP2 -0.44 -6.54 -0.34 2.36e-10 Intelligence (multi-trait analysis); CRC cis rs1801251 1.000 rs2592113 chr2:233669553 C/T cg25237894 chr2:233734115 C2orf82 0.51 8.27 0.41 3.29e-15 Coronary artery disease; CRC cis rs2836974 0.931 rs2776307 chr21:40713833 C/G cg17971929 chr21:40555470 PSMG1 -0.72 -9.99 -0.48 1.09e-20 Cognitive function; CRC cis rs10751667 0.961 rs10794358 chr11:985547 C/T ch.11.42038R chr11:967971 AP2A2 0.7 11.81 0.55 4.42e-27 Alzheimer's disease (late onset); CRC cis rs7811142 0.943 rs28660238 chr7:100023308 C/T cg00814883 chr7:100076585 TSC22D4 -0.7 -9.14 -0.45 6.84e-18 Platelet count; CRC cis rs875971 0.522 rs9530 chr7:65425894 A/G cg02869306 chr7:64672164 INTS4L1 -0.35 -5.77 -0.3 1.88e-8 Aortic root size; CRC cis rs72945132 0.825 rs72947052 chr11:70188575 A/G cg00319359 chr11:70116639 PPFIA1 0.71 6.66 0.34 1.12e-10 Coronary artery disease; CRC cis rs896854 0.530 rs10956934 chr8:95992473 C/A cg23172400 chr8:95962367 TP53INP1 -0.46 -7.65 -0.39 2.18e-13 Type 2 diabetes; CRC cis rs2239547 0.563 rs4302374 chr3:52905802 T/C cg11645453 chr3:52864694 ITIH4 0.55 9.5 0.46 4.51e-19 Schizophrenia; CRC cis rs9611565 0.659 rs9607815 chr22:41950671 A/T cg17554472 chr22:41940697 POLR3H -0.56 -6.11 -0.32 2.86e-9 Vitiligo; CRC cis rs6860806 0.661 rs3763112 chr5:131586480 A/G cg12564285 chr5:131593104 PDLIM4 0.49 9.37 0.46 1.22e-18 Breast cancer; CRC cis rs2635047 0.565 rs2571004 chr18:44710302 T/A cg19077165 chr18:44547161 KATNAL2 -0.42 -6.62 -0.34 1.48e-10 Educational attainment; CRC cis rs951366 0.764 rs708725 chr1:205744138 G/T cg26354017 chr1:205819088 PM20D1 0.74 11.35 0.53 2.08e-25 Menarche (age at onset); CRC cis rs4400599 0.618 rs1194582 chr1:154215973 A/G cg26808167 chr1:154192205 UBAP2L;C1orf43 -0.36 -5.71 -0.3 2.49e-8 Platelet distribution width; CRC cis rs7618501 0.521 rs55692411 chr3:49911155 G/A cg24308560 chr3:49941425 MST1R -0.45 -6.96 -0.36 1.84e-11 Intelligence (multi-trait analysis); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg16586002 chr3:196594898 SENP5 0.4 6.13 0.32 2.47e-9 Intelligence (multi-trait analysis); CRC trans rs9858542 0.953 rs9818590 chr3:49525096 A/G cg21659725 chr3:3221576 CRBN -0.68 -9.33 -0.46 1.64e-18 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs929354 0.685 rs1808217 chr7:157002741 T/C cg05182265 chr7:156933206 UBE3C -0.76 -14.49 -0.62 3.8e-37 Body mass index; CRC trans rs4263408 0.934 rs9683743 chr4:39703194 A/C cg16415856 chr7:99006352 BUD31;PDAP1 -0.42 -6.25 -0.33 1.3e-9 Plasma amyloid beta peptide concentrations (ABx-40); CRC cis rs56307353 0.753 rs62129495 chr19:1962789 T/C cg24355006 chr19:1969744 CSNK1G2 0.5 8.07 0.41 1.31e-14 Coronary artery disease; CRC cis rs7224685 0.501 rs781839 chr17:3961489 C/T cg10724054 chr17:3904396 NA -0.47 -7.8 -0.4 8.14e-14 Type 2 diabetes; CRC cis rs6456156 0.792 rs10946214 chr6:167516122 G/A cg07513332 chr6:167530253 CCR6 0.37 6.28 0.33 1.1e-9 Primary biliary cholangitis; CRC cis rs2839186 0.647 rs9976233 chr21:47616913 G/A cg11766577 chr21:47581405 C21orf56 0.4 6.41 0.33 5.03e-10 Testicular germ cell tumor; CRC cis rs60871478 1.000 rs67721251 chr7:825114 T/C cg05535760 chr7:792225 HEATR2 0.82 11.15 0.52 1.05e-24 Cerebrospinal P-tau181p levels; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg21796825 chr12:64173751 TMEM5 0.47 6.68 0.35 1.03e-10 Response to antipsychotic treatment; CRC cis rs863345 0.604 rs6669271 chr1:158471999 A/G cg12129480 chr1:158549410 OR10X1 -0.28 -5.92 -0.31 7.99e-9 Pneumococcal bacteremia; CRC cis rs6714710 0.603 rs11681535 chr2:98488949 G/C cg26665480 chr2:98280029 ACTR1B 0.53 7.34 0.37 1.74e-12 Posterior cortical atrophy and Alzheimer's disease; CRC cis rs2530545 0.590 rs4313062 chr7:34647331 T/C cg14401837 chr7:34697493 NPSR1 0.37 5.83 0.31 1.29e-8 IgG glycosylation; CRC cis rs597539 0.690 rs11228383 chr11:68623228 T/G cg06028808 chr11:68637592 NA 0.4 6.19 0.32 1.79e-9 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs3741151 0.773 rs17310374 chr11:73274874 T/C cg17517138 chr11:73019481 ARHGEF17 0.96 7.44 0.38 8.7e-13 GIP levels in response to oral glucose tolerance test (120 minutes); CRC trans rs1814175 0.538 rs1684260 chr11:49224231 G/A cg11707556 chr5:10655725 ANKRD33B 0.38 7.06 0.36 9.69e-12 Height; CRC cis rs11122272 0.614 rs78172021 chr1:231525160 A/T cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.54 -8.14 -0.41 7.99e-15 Hemoglobin concentration; CRC trans rs9858542 0.953 rs71324979 chr3:49619651 T/C cg21582582 chr3:182698605 DCUN1D1 -0.52 -6.36 -0.33 6.83e-10 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs7208859 0.614 rs216412 chr17:28903394 A/G cg13385521 chr17:29058706 SUZ12P -0.46 -6.11 -0.32 2.77e-9 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs6942756 0.806 rs6467240 chr7:128984018 T/C cg02491457 chr7:128862824 NA -0.63 -8.64 -0.43 2.44e-16 White matter hyperintensity burden; CRC cis rs9463078 0.669 rs9381364 chr6:45069673 T/C cg25276700 chr6:44698697 NA -0.24 -5.76 -0.3 1.95e-8 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; CRC cis rs919433 1.000 rs1429414 chr2:198162430 C/T cg03934865 chr2:198174659 NA -0.43 -7.4 -0.38 1.17e-12 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC cis rs4604732 0.631 rs34330532 chr1:247626844 G/C cg12758973 chr1:247694275 LOC148824;OR2C3 0.42 6.14 0.32 2.32e-9 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CRC cis rs3924048 0.547 rs72642661 chr1:12612873 C/G cg23650765 chr1:12612165 NA 0.38 7.34 0.38 1.65e-12 Optic cup area; CRC cis rs9303280 0.719 rs56750287 chr17:38062944 A/C cg17344932 chr17:38183730 MED24;SNORD124 0.39 6.25 0.33 1.28e-9 Self-reported allergy; CRC cis rs9372498 0.572 rs56082110 chr6:118909480 A/G cg01339444 chr6:118972232 C6orf204 0.53 5.87 0.31 1.04e-8 Diastolic blood pressure; CRC cis rs2243480 0.522 rs1638736 chr7:66092308 A/T cg18252515 chr7:66147081 NA -1.02 -10.08 -0.49 5.44e-21 Diabetic kidney disease; CRC trans rs11343 0.675 rs7359333 chr16:19262344 A/T cg07869994 chr3:174095190 NA -0.47 -6.37 -0.33 6.54e-10 Parkinson's disease; CRC cis rs1475911 1.000 rs12482477 chr21:43517233 T/A cg19766460 chr21:43528205 UMODL1;C21orf128 0.68 8.0 0.4 2.19e-14 IgG glycosylation; CRC cis rs10504229 0.911 rs77203035 chr8:58175458 C/A cg05313129 chr8:58192883 C8orf71 -0.47 -6.99 -0.36 1.49e-11 Developmental language disorder (linguistic errors); CRC cis rs3761847 0.500 rs7037673 chr9:123740484 C/T cg09419670 chr9:123605666 PSMD5;LOC253039 0.4 6.2 0.32 1.7e-9 Rheumatoid arthritis; CRC cis rs2408955 0.522 rs6580650 chr12:48418556 G/T cg15465823 chr12:48382534 COL2A1 -0.36 -5.9 -0.31 9.21e-9 Glycated hemoglobin levels; CRC cis rs7618915 0.547 rs7642198 chr3:52677960 T/C cg18099408 chr3:52552593 STAB1 -0.43 -7.08 -0.36 8.86e-12 Bipolar disorder; CRC cis rs8072100 0.935 rs12150231 chr17:45717091 G/A cg08085267 chr17:45401833 C17orf57 0.65 10.64 0.51 6.35e-23 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs1552244 0.554 rs3732965 chr3:10048760 A/C cg02579736 chr3:10068473 FANCD2;CIDECP 0.67 9.42 0.46 8.14e-19 Alzheimer's disease; CRC cis rs881375 0.692 rs2072438 chr9:123651301 T/C cg14255062 chr9:123606675 PSMD5;LOC253039 0.38 6.06 0.32 3.83e-9 Rheumatoid arthritis; CRC cis rs589448 1.000 rs589448 chr12:69752200 A/G cg22834771 chr12:69754056 YEATS4 -0.56 -8.73 -0.43 1.33e-16 Cerebrospinal fluid biomarker levels; CRC cis rs7552404 1.000 rs6672180 chr1:76123973 C/G cg03433033 chr1:76189801 ACADM 0.81 11.35 0.53 2.04e-25 Blood metabolite levels;Acylcarnitine levels; CRC cis rs12477438 0.501 rs11688004 chr2:99735052 G/T cg14399236 chr2:99771627 LIPT1;TSGA10 0.74 12.36 0.56 4.57e-29 Chronic sinus infection; CRC cis rs10484885 0.824 rs72919976 chr6:90526686 C/G cg13799429 chr6:90582589 CASP8AP2 -0.71 -7.62 -0.39 2.75e-13 QRS interval (sulfonylurea treatment interaction); CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg00400334 chr2:85981962 ATOH8 -0.49 -6.05 -0.32 3.93e-9 Diisocyanate-induced asthma; CRC trans rs2303319 0.504 rs58622044 chr2:162596287 A/G cg03774468 chr3:140950104 ACPL2 -0.66 -6.1 -0.32 3.01e-9 Cognitive function; CRC cis rs6951245 0.572 rs75083636 chr7:1050800 C/T cg26224354 chr7:1096374 C7orf50;GPR146 -0.92 -7.91 -0.4 3.98e-14 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs9916302 0.904 rs4794814 chr17:37696852 G/A cg00129232 chr17:37814104 STARD3 -0.54 -8.1 -0.41 1.08e-14 Glomerular filtration rate (creatinine); CRC cis rs11864453 1.000 rs2278027 chr16:72051369 A/G cg23815491 chr16:72088622 HP 0.59 9.25 0.45 2.93e-18 Fibrinogen levels; CRC cis rs10946940 0.965 rs10946935 chr6:27501345 T/C cg15845792 chr6:28175446 NA -0.45 -6.16 -0.32 2.14e-9 Systemic lupus erythematosus; CRC cis rs9420 1.000 rs543725 chr11:57483039 A/T cg23127183 chr11:57508653 C11orf31 -0.53 -7.43 -0.38 9.4e-13 Schizophrenia; CRC cis rs34375054 0.526 rs7302475 chr12:125677886 T/C cg02766259 chr12:125626809 AACS -0.45 -7.73 -0.39 1.33e-13 Post bronchodilator FEV1/FVC ratio; CRC cis rs1448094 0.511 rs17279133 chr12:86162353 G/A cg00310523 chr12:86230176 RASSF9 0.36 5.91 0.31 8.34e-9 Major depressive disorder; CRC cis rs10504229 0.593 rs77607045 chr8:58010464 T/C cg11062466 chr8:58055876 NA 0.53 6.58 0.34 1.85e-10 Developmental language disorder (linguistic errors); CRC cis rs1862618 0.802 rs2591949 chr5:56132627 T/C cg12311346 chr5:56204834 C5orf35 -0.78 -10.28 -0.49 1.11e-21 Initial pursuit acceleration; CRC cis rs2836974 0.555 rs35909862 chr21:40621158 G/A cg06238570 chr21:40685208 BRWD1 -0.81 -12.8 -0.58 1.01e-30 Cognitive function; CRC cis rs13191362 1.000 rs13192894 chr6:163052444 T/A cg21926612 chr6:163149169 PACRG;PARK2 0.98 12.61 0.57 5.13e-30 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs9948 0.655 rs78424221 chr2:97410399 A/G cg20312557 chr2:97357134 FER1L5 -0.61 -5.67 -0.3 3.19e-8 Erectile dysfunction and prostate cancer treatment; CRC cis rs6840360 0.642 rs4235219 chr4:152346103 T/G cg09659197 chr4:152720779 NA 0.34 6.67 0.35 1.06e-10 Intelligence (multi-trait analysis); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg27180880 chr18:74844787 MBP 0.42 6.87 0.35 3.3e-11 Liver disease severity in Alagille syndrome; CRC trans rs11098499 0.908 rs7696649 chr4:120322177 G/A cg25214090 chr10:38739885 LOC399744 0.65 10.38 0.5 5.24e-22 Corneal astigmatism; CRC trans rs11039798 1.000 rs7104642 chr11:48588534 C/T cg15704280 chr7:45808275 SEPT13 0.64 6.27 0.33 1.16e-9 Axial length; CRC cis rs9650657 0.571 rs11783247 chr8:10788875 C/T cg27411982 chr8:10470053 RP1L1 -0.38 -5.78 -0.3 1.74e-8 Neuroticism; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg07145255 chr5:59995354 DEPDC1B 0.5 6.49 0.34 3.24e-10 Thyroid stimulating hormone; CRC cis rs1465370 0.720 rs1558917 chr7:130028723 C/T cg03229158 chr7:130009420 NA 0.45 6.45 0.34 3.91e-10 Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction);Waist circumference adjusted for BMI in active individuals;Waist circumference adjusted for body mass index; CRC cis rs898097 0.691 rs7222773 chr17:80907283 A/G cg15369054 chr17:80825471 TBCD -0.34 -5.67 -0.3 3.09e-8 Breast cancer; CRC cis rs929596 0.531 rs2741013 chr2:234509911 C/T cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.42 -5.73 -0.3 2.26e-8 Total bilirubin levels in HIV-1 infection; CRC cis rs8063761 0.640 rs4785760 chr16:90051438 G/A cg05185784 chr16:90016020 DEF8 0.6 9.6 0.47 2.1e-19 Squamous cell carcinoma; CRC cis rs7809950 0.817 rs2253833 chr7:107205669 A/G cg23024343 chr7:107201750 COG5 0.74 10.19 0.49 2.23e-21 Coronary artery disease; CRC cis rs9916302 0.851 rs11870631 chr17:37645129 C/T cg03013999 chr17:37608204 MED1 0.45 6.87 0.35 3.15e-11 Glomerular filtration rate (creatinine); CRC cis rs12699477 0.545 rs117125814 chr7:1910681 T/G cg20295408 chr7:1910781 MAD1L1 -0.38 -5.68 -0.3 3.04e-8 Testicular germ cell tumor; CRC cis rs17401966 1.000 rs17401966 chr1:10385471 C/T cg19773385 chr1:10388646 KIF1B 0.57 7.72 0.39 1.41e-13 Hepatocellular carcinoma; CRC cis rs7095944 0.584 rs10901814 chr10:126431281 G/C cg08799069 chr10:126477246 METTL10 -0.43 -6.48 -0.34 3.3e-10 Asthma; CRC cis rs4132509 1.000 rs6681863 chr1:243982709 C/G cg21452805 chr1:244014465 NA 0.51 6.74 0.35 7.29e-11 RR interval (heart rate); CRC cis rs7385804 0.796 rs2432930 chr7:100299024 A/G cg16850897 chr7:100343110 ZAN 0.46 7.18 0.37 4.78e-12 Iron status biomarkers;Mean corpuscular hemoglobin;Hematocrit;Iron status biomarkers (transferrin saturation);Red blood cell count;Iron status biomarkers (iron levels);Mean corpuscular volume;Hematological parameters; CRC trans rs1997103 0.954 rs6593235 chr7:55410986 A/G cg20935933 chr6:143382018 AIG1 0.55 7.05 0.36 1.04e-11 QRS interval (sulfonylurea treatment interaction); CRC cis rs7618915 0.501 rs767418 chr3:52767427 C/T cg18099408 chr3:52552593 STAB1 -0.47 -7.89 -0.4 4.59e-14 Bipolar disorder; CRC cis rs10894147 0.756 rs1783917 chr11:129741274 T/A cg27255275 chr11:129766154 NFRKB 0.41 5.75 0.3 2.07e-8 Obesity-related traits; CRC cis rs7607369 0.536 rs12694443 chr2:219664977 G/T cg02176678 chr2:219576539 TTLL4 -0.39 -6.36 -0.33 6.89e-10 Red blood cell count;Amyotrophic lateral sclerosis; CRC cis rs9916302 0.904 rs2061338 chr17:37421767 T/C cg03013999 chr17:37608204 MED1 0.47 7.32 0.37 1.94e-12 Glomerular filtration rate (creatinine); CRC trans rs875971 0.660 rs2191268 chr7:66110224 C/T ch.11.29638519R chr11:29681943 NA -0.42 -6.7 -0.35 9.12e-11 Aortic root size; CRC cis rs7647973 1.000 rs974495 chr3:49400482 T/C cg07690219 chr3:49449608 TCTA;RHOA -0.52 -6.18 -0.32 1.9e-9 Menarche (age at onset); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg07805240 chr7:8008383 GLCCI1 0.41 6.44 0.33 4.21e-10 Liver disease severity in Alagille syndrome; CRC cis rs4713118 0.662 rs9357060 chr6:28024486 C/G cg21251018 chr6:28226885 NKAPL 0.46 6.42 0.33 4.71e-10 Parkinson's disease; CRC cis rs826838 0.967 rs2069211 chr12:39128892 C/T cg26384229 chr12:38710491 ALG10B -0.64 -9.67 -0.47 1.21e-19 Heart rate; CRC trans rs6951245 1.000 rs28399710 chr7:1070631 G/T cg13565492 chr6:43139072 SRF -0.71 -7.31 -0.37 2.04e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC trans rs11039798 0.588 rs59777067 chr11:49015350 C/T cg15704280 chr7:45808275 SEPT13 0.65 6.47 0.34 3.57e-10 Axial length; CRC trans rs11098499 0.909 rs7659501 chr4:120371552 G/T cg25214090 chr10:38739885 LOC399744 0.66 10.47 0.5 2.41e-22 Corneal astigmatism; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg14751398 chr6:20402153 E2F3 0.43 6.4 0.33 5.2e-10 Intelligence (multi-trait analysis); CRC cis rs8078723 0.714 rs2241244 chr17:38153554 G/C cg17467752 chr17:38218738 THRA -0.57 -8.87 -0.44 4.81e-17 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); CRC cis rs2294693 0.945 rs9369260 chr6:41010368 C/G cg14769373 chr6:40998127 UNC5CL 0.46 5.97 0.31 6.14e-9 Gastric cancer;Non-cardia gastric cancer; CRC cis rs10046574 1.000 rs10046574 chr7:135170470 C/T cg27474649 chr7:135195673 CNOT4 0.69 5.7 0.3 2.61e-8 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs4713118 0.869 rs9295742 chr6:27702832 G/A cg02683197 chr6:28174875 NA 0.63 8.62 0.43 2.81e-16 Parkinson's disease; CRC cis rs96067 0.805 rs4653160 chr1:36599547 C/T cg25304816 chr1:36627734 MAP7D1 0.43 6.13 0.32 2.46e-9 Corneal structure; CRC cis rs4731207 0.596 rs1525614 chr7:124658600 C/G cg23710748 chr7:124431027 NA -0.4 -6.45 -0.34 4.01e-10 Cutaneous malignant melanoma; CRC cis rs8031584 0.872 rs11634761 chr15:31243173 A/C cg08704250 chr15:31115839 NA -0.45 -8.06 -0.41 1.44e-14 Huntington's disease progression; CRC cis rs765787 0.530 rs12904331 chr15:45518293 C/T cg24006582 chr15:45444508 DUOX1 0.57 8.17 0.41 6.58e-15 Uric acid levels; CRC cis rs959260 0.557 rs12946365 chr17:73317644 C/T cg14668889 chr17:73230827 NUP85 -0.5 -7.42 -0.38 9.97e-13 Systemic lupus erythematosus; CRC cis rs7666738 0.830 rs4443293 chr4:99063120 G/A cg17366294 chr4:99064904 C4orf37 0.44 7.47 0.38 7.31e-13 Colonoscopy-negative controls vs population controls; CRC cis rs9796 0.689 rs692153 chr15:41452681 C/T cg18705301 chr15:41695430 NDUFAF1 -0.37 -5.97 -0.31 6.03e-9 Menopause (age at onset); CRC cis rs4665809 0.590 rs4665840 chr2:26444962 C/T cg08067268 chr2:26466485 HADHB;HADHA -0.65 -8.34 -0.42 2e-15 Gut microbiome composition (summer); CRC cis rs10504229 0.683 rs11786845 chr8:58133642 T/C cg04204079 chr8:58130323 NA -0.45 -5.75 -0.3 2.06e-8 Developmental language disorder (linguistic errors); CRC cis rs2204008 0.715 rs11525003 chr12:38332359 G/A cg13010199 chr12:38710504 ALG10B 0.46 6.1 0.32 3.04e-9 Bladder cancer; CRC trans rs41265665 0.661 rs1247636 chr4:74548474 T/A cg09364089 chr1:92948788 GFI1 -0.67 -6.0 -0.31 5.13e-9 Blood protein levels; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg23742887 chr15:34629998 SLC12A6 0.43 6.03 0.32 4.3e-9 Anxiety disorder; CRC cis rs826838 0.967 rs7963716 chr12:38876090 C/T cg26384229 chr12:38710491 ALG10B 0.72 9.65 0.47 1.48e-19 Heart rate; CRC cis rs12476592 0.602 rs1348803 chr2:63895617 C/T cg10828910 chr2:63850056 LOC388955 0.52 6.44 0.33 4.3e-10 Childhood ear infection; CRC cis rs4478858 0.735 rs10914361 chr1:31817542 T/G cg00250761 chr1:31883323 NA -0.44 -8.5 -0.42 6.71e-16 Alcohol dependence; CRC cis rs7833790 0.700 rs7825180 chr8:82723991 T/A cg27398817 chr8:82754497 SNX16 -0.44 -5.98 -0.31 5.83e-9 Diastolic blood pressure; CRC cis rs9457247 0.765 rs4710171 chr6:167430186 A/G cg23791538 chr6:167370224 RNASET2 -0.39 -5.88 -0.31 1e-8 Crohn's disease; CRC cis rs972578 0.837 rs5759017 chr22:43296324 A/C cg01576275 chr22:43409880 NA -0.39 -6.19 -0.32 1.74e-9 Mean platelet volume; CRC cis rs478304 0.637 rs11227255 chr11:65454044 C/T cg27068330 chr11:65405492 SIPA1 -0.66 -9.8 -0.48 4.69e-20 Acne (severe); CRC cis rs11608355 1.000 rs930356 chr12:109852372 T/C cg19025524 chr12:109796872 NA -0.47 -6.76 -0.35 6.22e-11 Neuroticism; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg05564086 chr17:26926050 SPAG5 0.37 6.07 0.32 3.58e-9 Liver disease severity in Alagille syndrome; CRC cis rs3772130 0.962 rs6784571 chr3:121539991 C/T cg20356878 chr3:121714668 ILDR1 0.51 7.99 0.4 2.27e-14 Cognitive performance; CRC cis rs3823572 0.586 rs2953625 chr7:133657789 A/G cg03336402 chr7:133662267 EXOC4 -0.67 -10.62 -0.51 7.59e-23 Intelligence (multi-trait analysis); CRC cis rs2243480 1.000 rs316330 chr7:65605372 C/A cg25985355 chr7:65971099 NA -0.52 -6.0 -0.31 5.22e-9 Diabetic kidney disease; CRC cis rs9733 0.680 rs3738484 chr1:150552330 G/T cg17724175 chr1:150552817 MCL1 -0.5 -8.16 -0.41 7.11e-15 Tonsillectomy; CRC cis rs951366 0.617 rs708727 chr1:205767885 G/A cg07157834 chr1:205819609 PM20D1 0.96 16.69 0.68 9.46e-46 Menarche (age at onset); CRC trans rs6951245 0.554 rs79367977 chr7:1152657 G/A cg13565492 chr6:43139072 SRF -0.82 -10.47 -0.5 2.4e-22 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs709400 1.000 rs709400 chr14:104149475 A/G cg12935359 chr14:103987150 CKB -0.4 -6.67 -0.35 1.09e-10 Body mass index; CRC cis rs75920871 0.528 rs7128772 chr11:116889411 T/A cg01368799 chr11:117014884 PAFAH1B2 -0.41 -5.9 -0.31 8.89e-9 Subjective well-being; CRC cis rs17376456 0.877 rs13156865 chr5:93390908 C/A cg09848695 chr5:92956644 FAM172A;MIR2277 0.63 6.16 0.32 2.11e-9 Diabetic retinopathy; CRC cis rs8040855 0.627 rs12909971 chr15:85588998 C/G cg10818794 chr15:86012489 AKAP13 -0.42 -5.64 -0.3 3.76e-8 Bulimia nervosa; CRC cis rs3736485 0.844 rs6493501 chr15:51815643 C/G cg08986416 chr15:51914746 DMXL2 0.49 7.12 0.37 6.66e-12 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs1538970 0.961 rs884962 chr1:45847981 G/A cg05343316 chr1:45956843 TESK2 0.69 9.08 0.45 1.04e-17 Platelet count; CRC cis rs6445967 0.966 rs35955376 chr3:58297779 G/A cg23715586 chr3:58305044 RPP14 0.35 5.84 0.31 1.25e-8 Platelet count; CRC cis rs7312933 0.703 rs10880259 chr12:42558003 T/C cg11827402 chr12:42719852 PPHLN1;ZCRB1 0.64 8.82 0.44 6.95e-17 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CRC cis rs8053891 0.615 rs2287997 chr16:72140553 G/A cg23815491 chr16:72088622 HP 0.54 6.17 0.32 2.03e-9 Coronary artery disease; CRC cis rs123509 0.913 rs339685 chr3:42782952 C/G cg12982090 chr3:42733453 KBTBD5 0.54 7.05 0.36 1.07e-11 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs7843479 0.524 rs1031884 chr8:21788984 C/T cg16476235 chr8:21771668 DOK2 0.38 6.21 0.32 1.62e-9 Mean corpuscular volume; CRC cis rs6089584 0.888 rs2146853 chr20:60617908 A/T cg06108461 chr20:60628389 TAF4 -0.92 -15.9 -0.66 1.24e-42 Body mass index; CRC cis rs6577655 0.517 rs11998030 chr8:135585325 C/T cg17885191 chr8:135476712 NA 0.48 5.75 0.3 1.99e-8 Visceral adipose tissue/subcutaneous adipose tissue ratio; CRC cis rs1127311 1.000 rs10908419 chr1:154567699 G/A cg17218026 chr1:154582156 ADAR 0.63 10.67 0.51 5.21e-23 C-reactive protein levels or triglyceride levels (pleiotropy); CRC cis rs4713118 0.868 rs742047 chr6:27739380 A/G cg06470822 chr6:28175283 NA 0.85 9.7 0.47 1.01e-19 Parkinson's disease; CRC cis rs3820068 0.603 rs3766163 chr1:15986547 T/C cg27534772 chr1:16042836 PLEKHM2 0.53 9.88 0.48 2.43e-20 Systolic blood pressure; CRC cis rs1545257 0.505 rs7583687 chr2:24634003 C/G cg06627628 chr2:24431161 ITSN2 -0.46 -6.74 -0.35 7.21e-11 Sjögren's syndrome; CRC cis rs1003719 1.000 rs2154536 chr21:38492147 G/C cg10648535 chr21:38446584 PIGP;TTC3 0.5 6.78 0.35 5.64e-11 Eye color traits; CRC cis rs950169 0.545 rs4354897 chr15:84644971 T/C cg11189052 chr15:85197271 WDR73 0.55 7.28 0.37 2.4e-12 Schizophrenia; CRC cis rs2836950 0.545 rs2836952 chr21:40616651 G/C cg11644478 chr21:40555479 PSMG1 -0.48 -7.09 -0.36 8.14e-12 Menarche (age at onset); CRC cis rs10540 0.908 rs71487293 chr11:486414 G/A cg19913688 chr11:428466 ANO9 -0.73 -7.4 -0.38 1.18e-12 Body mass index; CRC cis rs9322193 0.962 rs9765929 chr6:150090816 T/C cg00933542 chr6:150070202 PCMT1 0.28 5.69 0.3 2.75e-8 Lung cancer; CRC cis rs7945705 0.747 rs10840158 chr11:9020897 A/C cg14711859 chr11:8959438 ASCL3 0.37 6.2 0.32 1.73e-9 Hemoglobin concentration; CRC cis rs6951245 1.000 rs75016635 chr7:1094121 G/A cg03188948 chr7:1209495 NA 0.66 6.96 0.36 1.9e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs9322193 0.923 rs10782318 chr6:150075273 A/G cg05861140 chr6:150128134 PCMT1 -0.4 -6.26 -0.33 1.18e-9 Lung cancer; CRC cis rs6988985 0.765 rs4641039 chr8:143977819 T/C cg10324643 chr8:143916377 GML 0.38 6.27 0.33 1.15e-9 Plasma androstenedione levels in resected early stage-receptor positive breast cancer; CRC cis rs4243830 0.579 rs10779794 chr1:6612651 C/G cg05709478 chr1:6581295 PLEKHG5 -0.57 -6.81 -0.35 4.6e-11 Body mass index; CRC cis rs2635047 0.638 rs16954999 chr18:44610718 T/C cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.38 5.8 0.3 1.55e-8 Educational attainment; CRC cis rs12760731 0.565 rs11585236 chr1:178108441 G/A cg00404053 chr1:178313656 RASAL2 1.08 11.32 0.53 2.69e-25 Obesity-related traits; CRC cis rs17433780 0.808 rs7541867 chr1:89513537 G/A cg09516651 chr1:89888402 LOC400759 0.5 7.75 0.39 1.14e-13 Carotid intima media thickness; CRC cis rs1448094 0.534 rs974818 chr12:86144307 T/C cg25456477 chr12:86230367 RASSF9 -0.36 -6.06 -0.32 3.68e-9 Major depressive disorder; CRC cis rs6951245 0.744 rs10265758 chr7:1172518 C/T cg26224354 chr7:1096374 C7orf50;GPR146 -0.79 -10.7 -0.51 4.12e-23 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs4237845 0.735 rs11172375 chr12:58291574 G/C cg00677455 chr12:58241039 CTDSP2 0.65 9.12 0.45 7.49e-18 Intelligence (multi-trait analysis); CRC cis rs9549328 0.700 rs34890317 chr13:113617245 G/C cg17524180 chr13:113633600 MCF2L 0.52 9.51 0.46 4.32e-19 Systolic blood pressure; CRC cis rs56775891 1.000 rs4799088 chr18:77573548 A/G cg02536541 chr18:77568900 NA -0.38 -5.62 -0.3 4.03e-8 Schizophrenia; CRC cis rs7727544 1.000 rs7727038 chr5:131590257 C/T cg18301423 chr5:131593218 PDLIM4 0.31 5.93 0.31 7.79e-9 Blood metabolite levels; CRC cis rs2836974 0.604 rs2854727 chr21:40713787 A/G cg11644478 chr21:40555479 PSMG1 0.48 6.99 0.36 1.5e-11 Cognitive function; CRC cis rs4713118 0.621 rs9295755 chr6:28033174 C/T cg21251018 chr6:28226885 NKAPL -0.47 -6.4 -0.33 5.49e-10 Parkinson's disease; CRC cis rs6761276 0.899 rs13398125 chr2:113834835 G/A cg09040174 chr2:113837401 NA 0.65 10.3 0.49 9.83e-22 Protein quantitative trait loci; CRC cis rs7666738 0.830 rs62318470 chr4:98925846 A/C cg17366294 chr4:99064904 C4orf37 0.43 7.32 0.37 1.95e-12 Colonoscopy-negative controls vs population controls; CRC trans rs2303319 0.504 rs62189055 chr2:162625749 C/A cg10272801 chr16:14013773 ERCC4 -0.69 -6.16 -0.32 2.15e-9 Cognitive function; CRC cis rs7258465 0.896 rs8103660 chr19:18566395 T/C cg01065977 chr19:18549689 ISYNA1 -0.39 -6.14 -0.32 2.44e-9 Breast cancer; CRC cis rs6685188 0.920 rs10751444 chr1:205662144 A/G cg07157834 chr1:205819609 PM20D1 -0.43 -5.94 -0.31 7.15e-9 White blood cell count (basophil);Basophil percentage of white cells; CRC cis rs524281 0.817 rs10791859 chr11:65978453 C/T cg14541915 chr11:65894463 PACS1 0.34 5.65 0.3 3.39e-8 Electroencephalogram traits; CRC cis rs10504229 0.683 rs6998040 chr8:58110155 G/T cg02725872 chr8:58115012 NA 0.65 11.35 0.53 2.11e-25 Developmental language disorder (linguistic errors); CRC cis rs8058578 0.943 rs3747486 chr16:30786927 C/T cg02466173 chr16:30829666 NA -0.77 -12.21 -0.56 1.55e-28 Multiple myeloma; CRC cis rs4332037 0.901 rs7791899 chr7:1935988 T/C cg23422044 chr7:1970798 MAD1L1 -0.61 -7.5 -0.38 5.95e-13 Bipolar disorder; CRC cis rs8038465 0.638 rs12594175 chr15:73973186 C/T cg15420318 chr15:73925796 NPTN 0.42 6.36 0.33 6.65e-10 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs4665809 0.590 rs62128455 chr2:26466530 G/A cg22920501 chr2:26401640 FAM59B 0.83 11.96 0.55 1.28e-27 Gut microbiome composition (summer); CRC trans rs66573146 1.000 rs55913461 chr4:7017509 C/T cg07817883 chr1:32538562 TMEM39B 1.49 11.99 0.55 9.79e-28 Granulocyte percentage of myeloid white cells; CRC trans rs9956878 0.555 rs8085188 chr18:73544676 A/G cg14331148 chr19:47551893 TMEM160 -0.39 -6.32 -0.33 8.69e-10 Obesity-related traits; CRC cis rs73206853 0.764 rs7980838 chr12:110672978 T/A cg12870014 chr12:110450643 ANKRD13A 0.83 10.43 0.5 3.46e-22 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC cis rs9868809 0.649 rs3733086 chr3:48699519 C/T cg07636037 chr3:49044803 WDR6 -0.65 -5.78 -0.3 1.71e-8 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; CRC cis rs9457247 0.534 rs12055488 chr6:167379570 A/G cg23791538 chr6:167370224 RNASET2 0.52 7.94 0.4 3.29e-14 Crohn's disease; CRC cis rs791888 0.929 rs791887 chr10:89411554 A/G cg13926569 chr10:89418898 PAPSS2 -0.44 -6.38 -0.33 5.89e-10 Magnesium levels; CRC cis rs2404602 0.692 rs58361452 chr15:76973372 T/C cg22467129 chr15:76604101 ETFA -0.39 -6.54 -0.34 2.38e-10 Blood metabolite levels; CRC cis rs4665809 0.590 rs35727620 chr2:26458364 G/A cg25036284 chr2:26402008 FAM59B 0.61 7.76 0.39 1.09e-13 Gut microbiome composition (summer); CRC cis rs7666738 0.716 rs13136721 chr4:99085602 G/A cg05340658 chr4:99064831 C4orf37 0.51 7.61 0.39 2.83e-13 Colonoscopy-negative controls vs population controls; CRC cis rs1451375 0.583 rs3807556 chr7:50610536 G/A cg18232548 chr7:50535776 DDC 0.45 5.77 0.3 1.88e-8 Malaria; CRC cis rs9322193 0.923 rs10872651 chr6:150089409 A/T cg13206674 chr6:150067644 NUP43 0.67 9.37 0.46 1.22e-18 Lung cancer; CRC cis rs1218582 0.772 rs2335408 chr1:154915977 G/A cg09359103 chr1:154839909 KCNN3 -0.69 -11.95 -0.55 1.38e-27 Prostate cancer; CRC cis rs6496667 0.865 rs13329288 chr15:90897451 C/T cg04176472 chr15:90893244 GABARAPL3 0.52 7.95 0.4 3.04e-14 Rheumatoid arthritis; CRC cis rs751728 0.664 rs12190029 chr6:33749152 T/A cg25922239 chr6:33757077 LEMD2 0.46 6.85 0.35 3.63e-11 Crohn's disease; CRC cis rs6459788 0.502 rs9692347 chr7:157232659 C/T cg17306686 chr7:157230923 NA 0.46 6.61 0.34 1.53e-10 Epstein-Barr virus copy number in lymphoblastoid cell lines; CRC cis rs12711979 0.509 rs10191674 chr2:3827891 C/T cg17052675 chr2:3827356 NA -0.85 -20.84 -0.75 4.37e-62 Itch intensity from mosquito bite adjusted by bite size; CRC cis rs4908768 0.501 rs7518608 chr1:8557320 C/G cg20416874 chr1:8611966 RERE -0.45 -6.42 -0.33 4.68e-10 Neuroticism (multi-trait analysis);Subjective well-being (multi-trait analysis); CRC cis rs9534288 0.763 rs9534273 chr13:46566988 A/G cg15192986 chr13:46630673 CPB2 -0.67 -9.86 -0.48 2.81e-20 Blood protein levels; CRC cis rs4727027 0.933 rs9718383 chr7:148857624 A/T cg23583168 chr7:148888333 NA 0.93 16.65 0.68 1.38e-45 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC trans rs944990 0.595 rs10123378 chr9:96375217 C/T cg05570707 chr2:24270316 C2orf44 0.39 5.97 0.31 6.04e-9 Body mass index; CRC cis rs9427116 0.502 rs903323 chr1:154572228 A/G cg17218026 chr1:154582156 ADAR -0.63 -10.77 -0.51 2.36e-23 Blood protein levels; CRC cis rs3796352 1.000 rs2336541 chr3:52974630 G/C cg07884673 chr3:53033167 SFMBT1 0.69 6.12 0.32 2.67e-9 Immune reponse to smallpox (secreted IL-2); CRC cis rs2408955 0.522 rs973398 chr12:48491048 A/G cg24011408 chr12:48396354 COL2A1 -0.44 -6.47 -0.34 3.47e-10 Glycated hemoglobin levels; CRC cis rs739496 0.542 rs7300400 chr12:111792179 A/C cg10833066 chr12:111807467 FAM109A 0.56 7.25 0.37 3.06e-12 Platelet count; CRC trans rs7730934 1.000 rs7726239 chr5:55295306 C/A cg10323188 chr3:28613979 NA 0.53 6.14 0.32 2.36e-9 Blood protein levels; CRC cis rs56114371 0.777 rs200483 chr6:27774824 C/T cg19041857 chr6:27730383 NA -0.75 -7.18 -0.37 4.64e-12 Breast cancer; CRC cis rs2732480 0.537 rs1061986 chr12:48736439 T/C cg21466736 chr12:48725269 NA -0.61 -9.06 -0.45 1.18e-17 Hemoglobin concentration;Red blood cell count;Hematocrit; CRC cis rs9430161 0.579 rs11121669 chr1:11039567 T/C cg02454025 chr1:11042201 C1orf127 0.94 15.65 0.65 1.22e-41 Ewing sarcoma; CRC cis rs7512552 0.809 rs2794685 chr1:150312268 C/T cg15654264 chr1:150340011 RPRD2 0.58 8.1 0.41 1.08e-14 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); CRC cis rs736408 0.677 rs1042779 chr3:52821011 A/G cg10802521 chr3:52805072 NEK4 -0.49 -7.5 -0.38 5.91e-13 Bipolar disorder; CRC cis rs6502050 0.835 rs9891962 chr17:80153594 T/C cg02741985 chr17:80059408 CCDC57 0.43 7.09 0.36 7.99e-12 Life satisfaction; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg00013441 chr12:123258908 CCDC62 0.41 6.42 0.33 4.88e-10 Liver disease severity in Alagille syndrome; CRC cis rs7811142 0.830 rs7341507 chr7:99951315 A/G cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.12 16.51 0.67 4.85e-45 Platelet count; CRC cis rs1707322 0.963 rs10789484 chr1:46406978 G/C cg03146154 chr1:46216737 IPP 0.5 7.09 0.36 8.33e-12 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg24037166 chr10:75255724 PPP3CB 0.36 5.97 0.31 6.05e-9 Liver disease severity in Alagille syndrome; CRC cis rs3096299 0.719 rs2965817 chr16:89513234 C/T cg01788221 chr16:89496183 ANKRD11 -0.42 -6.27 -0.33 1.13e-9 Multiple myeloma (IgH translocation); CRC cis rs2836974 0.666 rs1888487 chr21:40683259 A/G cg17971929 chr21:40555470 PSMG1 -0.7 -10.67 -0.51 5.14e-23 Cognitive function; CRC trans rs1455244 0.700 rs7229302 chr18:11508904 G/T cg08858051 chr1:94313454 NA 0.45 6.6 0.34 1.65e-10 Schizophrenia; CRC cis rs2839186 0.872 rs2250213 chr21:47674275 G/A cg02776659 chr21:47717406 C21orf57 -0.34 -5.7 -0.3 2.61e-8 Testicular germ cell tumor; CRC cis rs2050392 0.861 rs303448 chr10:30727084 G/T cg25182066 chr10:30743637 MAP3K8 -0.41 -6.11 -0.32 2.86e-9 Inflammatory bowel disease; CRC cis rs8180040 0.676 rs7636252 chr3:47013542 T/G cg02527881 chr3:46936655 PTH1R -0.42 -7.96 -0.4 2.83e-14 Colorectal cancer; CRC cis rs2179367 0.959 rs9285519 chr6:149692935 G/A cg07828024 chr6:149772892 ZC3H12D -0.39 -6.49 -0.34 3.17e-10 Dupuytren's disease; CRC cis rs2834256 0.580 rs2040121 chr21:35146577 T/G cg14850771 chr21:34775459 IFNGR2 0.42 6.03 0.32 4.38e-9 Red cell distribution width; CRC cis rs9583531 0.629 rs7991766 chr13:111380684 A/G cg24331049 chr13:111365604 ING1 0.53 6.98 0.36 1.65e-11 Coronary artery disease; CRC cis rs17067123 0.614 rs6813463 chr4:180068739 A/T cg26610307 chr4:180072759 NA -0.56 -6.72 -0.35 7.84e-11 Response to hepatitis C treatment; CRC cis rs853679 0.517 rs2281588 chr6:28072602 G/A cg02683197 chr6:28174875 NA 0.82 10.03 0.48 7.9e-21 Depression; CRC cis rs2777491 1.000 rs7177641 chr15:41743426 C/T cg18705301 chr15:41695430 NDUFAF1 -0.66 -11.43 -0.53 1.04e-25 Ulcerative colitis; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg27220681 chr17:685915 RNMTL1;GLOD4 0.41 6.29 0.33 1.02e-9 Intelligence (multi-trait analysis); CRC cis rs9399135 0.967 rs4896119 chr6:135293391 C/T cg22676075 chr6:135203613 NA 0.42 6.41 0.33 4.95e-10 Red blood cell count; CRC cis rs8063761 0.640 rs4785760 chr16:90051438 G/A cg12064134 chr16:90016061 DEF8 0.61 10.5 0.5 1.89e-22 Squamous cell carcinoma; CRC cis rs853679 0.517 rs9393896 chr6:28127703 C/T cg15786705 chr6:28176104 NA 0.78 9.83 0.48 3.57e-20 Depression; CRC cis rs908922 0.676 rs498184 chr1:152501423 G/C cg23254163 chr1:152506842 NA 0.46 9.02 0.45 1.6e-17 Hair morphology; CRC cis rs10486722 0.606 rs6463040 chr7:41793377 A/G cg22138096 chr7:41772439 LOC285954 0.62 7.28 0.37 2.51e-12 Pit-and-Fissure caries; CRC cis rs6502050 0.698 rs36043222 chr17:80117822 G/T cg02741985 chr17:80059408 CCDC57 0.43 7.17 0.37 5.1e-12 Life satisfaction; CRC cis rs9486715 0.867 rs1855533 chr6:97050265 T/C cg06623918 chr6:96969491 KIAA0776 -1.02 -20.58 -0.75 4.48e-61 Headache; CRC cis rs9292777 0.865 rs7711427 chr5:40414886 A/C cg09067459 chr5:40385259 NA 0.51 8.86 0.44 4.94e-17 Crohn's disease;Multiple sclerosis; CRC cis rs6502050 0.667 rs9892469 chr17:80093657 T/C cg09264619 chr17:80180166 NA -0.35 -5.86 -0.31 1.1e-8 Life satisfaction; CRC cis rs9322193 0.923 rs2297932 chr6:150039361 C/G cg13206674 chr6:150067644 NUP43 0.65 9.76 0.47 6.08e-20 Lung cancer; CRC cis rs514406 0.661 rs550561 chr1:53375134 C/T cg25767906 chr1:53392781 SCP2 -0.5 -7.68 -0.39 1.89e-13 Monocyte count; CRC cis rs6724607 1.000 rs6724607 chr2:191466532 C/T cg10560079 chr2:191398806 TMEM194B 0.5 7.04 0.36 1.09e-11 Pulse pressure; CRC cis rs875971 0.577 rs35072105 chr7:65609817 A/G cg18876405 chr7:65276391 NA -0.61 -10.74 -0.51 2.82e-23 Aortic root size; CRC cis rs916888 0.773 rs199443 chr17:44819565 C/T cg01570182 chr17:44337453 NA 1.22 14.47 0.62 4.45e-37 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs2066819 1.000 rs74496027 chr12:56726340 C/T cg26714650 chr12:56694279 CS -1.41 -11.5 -0.54 5.96e-26 Psoriasis vulgaris; CRC trans rs66573146 1.000 rs55833486 chr4:6978729 C/A cg07817883 chr1:32538562 TMEM39B 1.34 12.9 0.58 4.23e-31 Granulocyte percentage of myeloid white cells; CRC trans rs6550704 0.687 rs9865314 chr3:22634337 A/G cg22950391 chr6:28109938 ZNF192 -0.4 -6.02 -0.31 4.6e-9 Daytime sleep phenotypes; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg01433114 chr10:88853758 GLUD1;FAM35A 0.46 6.65 0.34 1.22e-10 Intelligence (multi-trait analysis); CRC cis rs344364 0.511 rs911392 chr16:1947259 A/G cg00046913 chr16:1877150 HAGH;FAHD1 -0.6 -6.24 -0.33 1.32e-9 Glomerular filtration rate in chronic kidney disease; CRC cis rs8177253 0.761 rs35332919 chr3:133519002 T/A cg01448562 chr3:133502909 NA -0.72 -13.01 -0.58 1.61e-31 Iron status biomarkers; CRC cis rs10504229 0.683 rs11786527 chr8:58131344 G/C cg22535103 chr8:58192502 C8orf71 -0.69 -9.14 -0.45 6.5e-18 Developmental language disorder (linguistic errors); CRC cis rs34172651 0.517 rs2303083 chr16:24835168 G/A cg06505273 chr16:24850292 NA 0.53 6.28 0.33 1.05e-9 Intelligence (multi-trait analysis); CRC cis rs6700896 0.897 rs11208701 chr1:66134698 C/T cg04111102 chr1:66153794 NA 0.35 6.1 0.32 3.03e-9 C-reactive protein;Mean corpuscular volume;Mean corpuscular hemoglobin; CRC cis rs7412746 0.658 rs2864869 chr1:150734655 G/A cg15448220 chr1:150897856 SETDB1 0.54 7.59 0.39 3.39e-13 Melanoma; CRC cis rs79349575 0.811 rs12601072 chr17:46997998 T/C cg22482690 chr17:47019901 SNF8 0.48 8.07 0.41 1.33e-14 Type 2 diabetes; CRC cis rs7945718 0.870 rs10831903 chr11:12758660 C/T cg25843174 chr11:12811716 TEAD1 0.51 9.22 0.45 3.64e-18 Educational attainment (years of education); CRC cis rs736408 0.562 rs12497998 chr3:52793602 C/T cg15147215 chr3:52552868 STAB1 -0.65 -10.97 -0.52 4.65e-24 Bipolar disorder; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg13487956 chr18:47340408 SCARNA17;ACAA2 0.37 6.03 0.32 4.29e-9 Liver disease severity in Alagille syndrome; CRC cis rs853679 0.517 rs9368558 chr6:28133306 A/G cg25164649 chr6:28176230 NA 0.78 9.66 0.47 1.33e-19 Depression; CRC trans rs10983614 1.000 rs7867776 chr9:120072627 A/G cg08821669 chr12:120875978 COX6A1 0.45 6.08 0.32 3.35e-9 Survival in pancreatic cancer; CRC cis rs77106637 0.929 rs1059000 chr11:72504972 G/C cg03713592 chr11:72463424 ARAP1 0.9 8.58 0.43 3.84e-16 Type 2 diabetes; CRC cis rs7408868 1.000 rs7245814 chr19:15274503 A/G cg14696996 chr19:15285081 NOTCH3 0.97 8.99 0.44 1.99e-17 Pulse pressure; CRC trans rs7395662 1.000 rs7944356 chr11:48610154 C/G cg21153622 chr11:89784906 NA -0.48 -7.68 -0.39 1.78e-13 HDL cholesterol; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg13452718 chr1:23670887 HNRNPR 0.45 6.28 0.33 1.09e-9 Response to antipsychotic treatment; CRC trans rs11992162 0.933 rs10108075 chr8:11832079 A/G cg06636001 chr8:8085503 FLJ10661 0.42 6.01 0.31 4.92e-9 Monocyte count; CRC cis rs4653767 1.000 rs10495249 chr1:226919119 A/G cg05049329 chr1:226924846 ITPKB 0.39 8.82 0.44 6.8e-17 Parkinson's disease; CRC cis rs4665809 0.627 rs1465720 chr2:26412638 G/T cg22920501 chr2:26401640 FAM59B -0.84 -11.97 -0.55 1.23e-27 Gut microbiome composition (summer); CRC cis rs12188164 0.543 rs890972 chr5:462465 C/A cg26850624 chr5:429559 AHRR 0.52 8.87 0.44 4.87e-17 Cystic fibrosis severity; CRC cis rs7923609 0.967 rs7920058 chr10:65293924 T/G cg08743896 chr10:65200160 JMJD1C -0.41 -5.78 -0.3 1.74e-8 Educational attainment;Liver enzyme levels (alkaline phosphatase); CRC cis rs13108904 0.901 rs6826029 chr4:1307689 A/G cg20887711 chr4:1340912 KIAA1530 0.43 6.35 0.33 7.13e-10 Obesity-related traits; CRC cis rs12497850 0.931 rs9840050 chr3:49133310 A/G cg20833759 chr3:49053208 WDR6;DALRD3 0.5 8.45 0.42 9.39e-16 Parkinson's disease; CRC cis rs1707322 0.964 rs785516 chr1:46564758 T/G cg06784218 chr1:46089804 CCDC17 -0.61 -10.54 -0.5 1.37e-22 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs7666738 0.830 rs6829567 chr4:99047340 T/C cg17366294 chr4:99064904 C4orf37 0.45 7.75 0.39 1.16e-13 Colonoscopy-negative controls vs population controls; CRC cis rs2033711 0.870 rs11669741 chr19:58960481 C/T cg26874164 chr19:58962979 ZNF324B -0.39 -5.68 -0.3 3.03e-8 Uric acid clearance; CRC cis rs2303759 0.918 rs2288480 chr19:49867016 C/G cg24324837 chr19:49891574 CCDC155 0.59 8.48 0.42 7.95e-16 Multiple sclerosis; CRC cis rs4253772 0.513 rs6008612 chr22:46707907 G/A cg24881330 chr22:46731750 TRMU 0.69 8.6 0.43 3.3e-16 LDL cholesterol;Cholesterol, total; CRC cis rs1552244 0.572 rs12107622 chr3:10171898 T/A cg10729496 chr3:10149963 C3orf24 0.51 5.9 0.31 8.81e-9 Alzheimer's disease; CRC trans rs7726839 0.507 rs72703100 chr5:614291 C/T cg25482853 chr8:67687455 SGK3 1.1 12.9 0.58 4.37e-31 Obesity-related traits; CRC cis rs3749237 0.615 rs11130202 chr3:49566715 C/T cg03060546 chr3:49711283 APEH 0.69 11.96 0.55 1.32e-27 Resting heart rate; CRC cis rs7493 0.760 rs17876092 chr7:95053313 C/A cg19678392 chr7:94953810 PON1 -0.61 -7.43 -0.38 9.49e-13 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs7223966 1.000 rs8075061 chr17:61804723 A/G cg23090583 chr17:61904693 PSMC5;FTSJ3 0.5 6.18 0.32 1.89e-9 Hip circumference adjusted for BMI;Body mass index; CRC cis rs1448094 0.817 rs10779220 chr12:86323543 T/A cg18827107 chr12:86230957 RASSF9 -0.42 -6.62 -0.34 1.48e-10 Major depressive disorder; CRC cis rs9611565 0.559 rs5758397 chr22:42019251 C/T cg03806693 chr22:41940476 POLR3H 1.0 11.32 0.53 2.52e-25 Vitiligo; CRC cis rs853679 0.723 rs9366718 chr6:28205502 A/T cg15845792 chr6:28175446 NA 0.75 7.86 0.4 5.59e-14 Depression; CRC cis rs459193 0.917 rs40270 chr5:55804552 A/C cg00049729 chr5:55776345 NA 0.4 5.77 0.3 1.82e-8 Coronary artery disease;Type 2 diabetes;Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);Waist-to-hip ratio adjusted for BMI in non-smokers;Waist-to-hip ratio adjusted for BMI (smoking interaction);Waist-to-hip ratio adjusted for body mass index;Waist-hip ratio;Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction); CRC cis rs739401 0.619 rs10766482 chr11:2961600 C/T cg08508325 chr11:3079039 CARS -0.41 -7.19 -0.37 4.38e-12 Longevity; CRC cis rs12024301 0.557 rs2231239 chr1:183602075 T/C cg11505048 chr1:183622726 RGL1;APOBEC4 0.75 6.81 0.35 4.6e-11 Peripheral arterial disease (traffic-related air pollution interaction); CRC trans rs7829975 0.522 rs6601689 chr8:8172283 C/T cg16141378 chr3:129829833 LOC729375 -0.43 -6.24 -0.33 1.37e-9 Mood instability; CRC cis rs11997175 0.599 rs66474258 chr8:33640225 A/T cg04338863 chr8:33670619 NA 0.38 6.52 0.34 2.58e-10 Body mass index; CRC cis rs739401 0.572 rs389285 chr11:3062673 G/A cg08508325 chr11:3079039 CARS -0.49 -8.65 -0.43 2.35e-16 Longevity; CRC cis rs1499614 0.803 rs1796229 chr7:66119661 G/A cg25985355 chr7:65971099 NA -0.51 -5.91 -0.31 8.44e-9 Gout; CRC cis rs7772486 0.790 rs2265919 chr6:146221753 A/G cg23711669 chr6:146136114 FBXO30 0.71 12.63 0.57 4.28e-30 Lobe attachment (rater-scored or self-reported); CRC cis rs7923609 0.967 rs7085018 chr10:65286667 T/C cg08743896 chr10:65200160 JMJD1C -0.41 -5.78 -0.3 1.74e-8 Educational attainment;Liver enzyme levels (alkaline phosphatase); CRC cis rs9910055 0.762 rs2526021 chr17:42213347 G/A cg10896456 chr17:42255109 ASB16;C17orf65 0.45 7.38 0.38 1.27e-12 Total body bone mineral density; CRC cis rs2019137 0.539 rs11123170 chr2:113978940 C/G cg12889195 chr2:113992843 PAX8;LOC440839;LOC654433 0.69 10.38 0.5 5.23e-22 Lymphocyte counts; CRC cis rs13217239 0.585 rs114919438 chr6:26963792 T/C cg05192639 chr6:26864778 GUSBL1 -0.31 -5.84 -0.31 1.25e-8 Schizophrenia; CRC cis rs8078723 0.668 rs4239225 chr17:38127112 G/A cg17344932 chr17:38183730 MED24;SNORD124 -0.51 -8.2 -0.41 5.64e-15 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); CRC cis rs4700695 0.764 rs152993 chr5:65262968 A/T cg21114390 chr5:65439923 SFRS12 0.57 6.88 0.35 3.05e-11 Facial morphology (factor 19); CRC cis rs7917772 0.503 rs10883732 chr10:104293461 G/A cg11453585 chr10:104263688 ACTR1A;SUFU 0.91 17.49 0.69 6.57e-49 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC cis rs7665147 1 rs7665147 chr4:57767327 T/A cg26694713 chr4:57773883 REST 0.48 5.9 0.31 9.01e-9 Platelet count; CRC cis rs10256972 0.567 rs2960835 chr7:1202963 A/G cg18765753 chr7:1198926 ZFAND2A -0.41 -7.07 -0.36 9.29e-12 Longevity;Endometriosis; CRC cis rs4819052 0.724 rs1304487 chr21:46657283 C/G cg11663144 chr21:46675770 NA 0.69 11.43 0.53 1.04e-25 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs2153535 0.580 rs9392220 chr6:8457946 G/A cg07606381 chr6:8435919 SLC35B3 0.69 11.15 0.52 1.04e-24 Motion sickness; CRC cis rs7224737 1.000 rs12603330 chr17:40290589 T/A cg02450064 chr17:40260053 DHX58 -0.42 -6.13 -0.32 2.54e-9 Fibrinogen levels; CRC cis rs73206853 0.764 rs56179460 chr12:111125774 C/G cg12870014 chr12:110450643 ANKRD13A 0.72 6.67 0.35 1.1e-10 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC cis rs6804368 0.553 rs9819139 chr3:30770421 G/A cg06106510 chr3:30762233 NA 0.35 5.62 0.3 4.01e-8 Blood metabolite levels; CRC trans rs615632 0.570 rs17734541 chr8:9708433 A/G cg06636001 chr8:8085503 FLJ10661 0.54 8.57 0.43 3.94e-16 Neuroticism; CRC cis rs728616 0.867 rs56008106 chr10:81953776 T/C cg05935833 chr10:81318306 SFTPA2 -0.75 -7.66 -0.39 2.06e-13 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs1218582 0.710 rs7553195 chr1:154837796 T/C cg03351412 chr1:154909251 PMVK 0.48 7.67 0.39 1.95e-13 Prostate cancer; CRC trans rs17361889 0.727 rs17458603 chr7:16279593 A/G cg08271366 chr16:82816457 CDH13 0.24 6.23 0.32 1.39e-9 Pediatric bone mineral content (hip); CRC cis rs7258465 1.000 rs10164323 chr19:18569492 C/T cg06953865 chr19:18549723 ISYNA1 -0.38 -5.76 -0.3 1.93e-8 Breast cancer; CRC cis rs13191362 0.935 rs73037930 chr6:162937146 A/C cg06582575 chr6:163149167 PACRG;PARK2 0.78 9.24 0.45 3.17e-18 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs4708431 0.539 rs35108423 chr6:168491898 A/G cg02770688 chr6:168491649 NA 0.4 5.97 0.31 6.13e-9 Attention deficit hyperactivity disorder (combined symptoms); CRC cis rs2979489 0.891 rs4449748 chr8:30304402 A/G cg26383811 chr8:30366931 RBPMS 0.69 9.68 0.47 1.12e-19 Mean corpuscular hemoglobin;Plateletcrit;Neutrophil count;Granulocyte count;Sum basophil neutrophil counts;Mean corpuscular volume;Myeloid white cell count;Sum neutrophil eosinophil counts; CRC cis rs67340775 0.541 rs200965 chr6:27866384 G/A cg06470822 chr6:28175283 NA 0.87 8.85 0.44 5.4e-17 Lung cancer in ever smokers; CRC cis rs13191362 1.000 rs34918316 chr6:163005386 A/G cg21926612 chr6:163149169 PACRG;PARK2 0.8 11.15 0.52 1.08e-24 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs7605827 0.964 rs6748427 chr2:15564799 T/C cg19274914 chr2:15703543 NA 0.38 5.84 0.31 1.23e-8 Educational attainment (years of education); CRC cis rs912057 0.526 rs1294400 chr6:6733421 A/G cg06612196 chr6:6737390 NA -0.63 -10.46 -0.5 2.75e-22 Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction); CRC cis rs7254114 0.578 rs73506605 chr19:11307564 G/A cg02815516 chr19:11306319 KANK2 -0.34 -6.51 -0.34 2.73e-10 Immature fraction of reticulocytes; CRC cis rs11167764 1.000 rs6887599 chr5:141484349 G/A cg23435118 chr5:141488016 NDFIP1 -0.46 -7.29 -0.37 2.27e-12 Crohn's disease; CRC cis rs9818758 0.545 rs11717978 chr3:48969036 T/A cg00383909 chr3:49044727 WDR6 1.33 12.69 0.57 2.59e-30 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; CRC cis rs9389248 0.690 rs6569982 chr6:135256495 C/G cg22676075 chr6:135203613 NA 0.64 10.01 0.48 9.33e-21 High light scatter reticulocyte percentage of red cells; CRC cis rs2404602 0.735 rs4886495 chr15:76738959 C/T cg03037974 chr15:76606532 NA 0.57 8.82 0.44 6.85e-17 Blood metabolite levels; CRC cis rs7666738 0.830 rs6854902 chr4:99033416 T/G cg17366294 chr4:99064904 C4orf37 0.44 7.48 0.38 6.96e-13 Colonoscopy-negative controls vs population controls; CRC cis rs11098499 0.629 rs28369518 chr4:120271630 T/C cg09307838 chr4:120376055 NA 0.6 9.3 0.46 1.95e-18 Corneal astigmatism; CRC cis rs2836950 0.565 rs8131132 chr21:40538256 T/C cg06238570 chr21:40685208 BRWD1 -0.6 -8.89 -0.44 4.07e-17 Menarche (age at onset); CRC cis rs826838 1.000 rs11609286 chr12:38875511 A/G cg13010199 chr12:38710504 ALG10B -0.45 -5.93 -0.31 7.86e-9 Heart rate; CRC cis rs2153535 0.580 rs1119690 chr6:8460660 G/A cg07606381 chr6:8435919 SLC35B3 0.68 10.95 0.52 5.22e-24 Motion sickness; CRC cis rs7552404 1.000 rs4949876 chr1:76173377 C/T cg10523679 chr1:76189770 ACADM 0.84 11.5 0.54 5.87e-26 Blood metabolite levels;Acylcarnitine levels; CRC trans rs116095464 0.619 rs2303741 chr5:218356 T/C cg00938859 chr5:1591904 SDHAP3 0.68 7.39 0.38 1.24e-12 Breast cancer; CRC cis rs6500395 1.000 rs1872654 chr16:48671050 C/T cg04672837 chr16:48644449 N4BP1 0.45 6.7 0.35 8.8e-11 Response to tocilizumab in rheumatoid arthritis; CRC cis rs11212617 0.935 rs652541 chr11:108226025 C/T cg12106634 chr11:108092400 ATM;NPAT -0.4 -5.74 -0.3 2.12e-8 Response to metformin in type 2 diabetes (glycemic); CRC cis rs12282928 1.000 rs10838845 chr11:48280299 C/T cg20307385 chr11:47447363 PSMC3 0.48 5.93 0.31 7.64e-9 Migraine - clinic-based; CRC cis rs7666738 0.830 rs3857217 chr4:99034347 T/C cg05340658 chr4:99064831 C4orf37 0.61 9.43 0.46 7.65e-19 Colonoscopy-negative controls vs population controls; CRC cis rs11190604 1.000 rs9420785 chr10:102240451 C/G cg07080220 chr10:102295463 HIF1AN 0.47 5.88 0.31 1.03e-8 Palmitoleic acid (16:1n-7) levels; CRC cis rs6500395 1.000 rs3743779 chr16:48574040 T/G cg04672837 chr16:48644449 N4BP1 0.44 6.55 0.34 2.2e-10 Response to tocilizumab in rheumatoid arthritis; CRC trans rs7819412 0.775 rs4841489 chr8:10936811 A/G cg16141378 chr3:129829833 LOC729375 0.45 6.44 0.33 4.33e-10 Triglycerides; CRC cis rs1799949 1.000 rs12516 chr17:41196408 G/A cg23758822 chr17:41437982 NA 0.8 13.7 0.6 4.08e-34 Menopause (age at onset); CRC cis rs6502050 0.835 rs8071737 chr17:80117537 T/C cg02741985 chr17:80059408 CCDC57 0.43 7.18 0.37 4.57e-12 Life satisfaction; CRC cis rs1107366 0.750 rs9825571 chr3:125900161 A/G cg08481491 chr3:125900108 ALDH1L1 -0.41 -7.26 -0.37 2.85e-12 Metabolite levels; CRC cis rs67311347 1.000 rs4973997 chr3:40460145 G/A cg09455208 chr3:40491958 NA 0.45 9.25 0.45 2.89e-18 Renal cell carcinoma; CRC cis rs9388451 0.839 rs10457469 chr6:126083658 G/A cg10911889 chr6:126070802 HEY2 0.37 5.64 0.3 3.61e-8 Brugada syndrome; CRC trans rs7647973 0.626 rs4855882 chr3:49715354 G/T cg21665057 chr3:196295764 WDR53;FBXO45 -0.61 -6.3 -0.33 9.55e-10 Menarche (age at onset); CRC trans rs1997103 1.000 rs6976824 chr7:55396115 A/C cg20935933 chr6:143382018 AIG1 0.54 7.05 0.36 1.08e-11 QRS interval (sulfonylurea treatment interaction); CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg02608231 chr3:47844363 DHX30 0.43 6.0 0.31 5.16e-9 Anxiety disorder; CRC cis rs514406 0.505 rs448788 chr1:53161620 A/G cg24675658 chr1:53192096 ZYG11B 0.67 10.02 0.48 8.5e-21 Monocyte count; CRC cis rs6502050 0.835 rs7221544 chr17:80087337 C/T cg09264619 chr17:80180166 NA 0.39 6.5 0.34 3.03e-10 Life satisfaction; CRC cis rs7809950 0.678 rs3801966 chr7:106824580 G/A cg23024343 chr7:107201750 COG5 -0.75 -10.15 -0.49 3.06e-21 Coronary artery disease; CRC cis rs7811142 1.000 rs11764818 chr7:100043055 G/A cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.74 10.11 0.49 4.15e-21 Platelet count; CRC cis rs2739330 0.753 rs4822452 chr22:24254363 C/T cg23131131 chr22:24373011 LOC391322 -0.63 -9.87 -0.48 2.8e-20 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs9733 0.596 rs6685702 chr1:150656307 A/G cg18016565 chr1:150552671 MCL1 0.46 6.74 0.35 6.91e-11 Tonsillectomy; CRC cis rs2839186 0.709 rs2839176 chr21:47678173 A/G cg13012494 chr21:47604986 C21orf56 0.41 6.21 0.32 1.63e-9 Testicular germ cell tumor; CRC trans rs2303319 0.504 rs62189052 chr2:162623869 C/G cg09481857 chr22:21368659 P2RX6;MGC16703 -0.64 -6.28 -0.33 1.08e-9 Cognitive function; CRC cis rs17209837 0.646 rs55747905 chr7:87127099 T/C cg00919237 chr7:87102261 ABCB4 -0.53 -6.7 -0.35 8.99e-11 Gallbladder cancer; CRC cis rs896543 0.657 rs10179774 chr2:237487588 C/T cg25295825 chr2:237489920 CXCR7 0.41 6.34 0.33 7.75e-10 Alcohol dependence (age at onset); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg01525597 chr12:1739061 WNT5B 0.46 6.47 0.34 3.6e-10 Response to antipsychotic treatment; CRC cis rs4721295 0.573 rs3779000 chr7:2181628 G/A cg02951883 chr7:2050386 MAD1L1 -0.59 -8.72 -0.43 1.39e-16 Schizophrenia, schizoaffective disorder or bipolar disorder; CRC trans rs7395662 0.526 rs4882001 chr11:48546675 A/G cg15704280 chr7:45808275 SEPT13 -0.48 -6.98 -0.36 1.61e-11 HDL cholesterol; CRC cis rs3771570 1.000 rs62186422 chr2:242249499 A/G cg21155796 chr2:242212141 HDLBP 0.64 7.03 0.36 1.21e-11 Prostate cancer; CRC cis rs6032067 0.852 rs17333180 chr20:43803708 C/A cg10761708 chr20:43804764 PI3 0.48 5.64 0.3 3.58e-8 Blood protein levels; CRC cis rs9322193 0.962 rs4380763 chr6:149999222 A/G cg13206674 chr6:150067644 NUP43 0.64 9.59 0.47 2.34e-19 Lung cancer; CRC cis rs9393777 0.513 rs13219181 chr6:27136225 A/G cg12292205 chr6:26970375 C6orf41 -0.77 -8.16 -0.41 7.07e-15 Intelligence (multi-trait analysis); CRC cis rs1799949 1.000 rs12944430 chr17:41330820 C/G cg25072359 chr17:41440525 NA 0.43 6.36 0.33 6.77e-10 Menopause (age at onset); CRC cis rs6089584 0.888 rs6142927 chr20:60605848 A/G cg23262073 chr20:60523788 NA -0.5 -7.3 -0.37 2.2e-12 Body mass index; CRC cis rs4862750 0.872 rs13143414 chr4:187878213 G/A cg22105103 chr4:187893119 NA 0.62 11.28 0.53 3.48e-25 Lobe attachment (rater-scored or self-reported); CRC cis rs12701220 0.655 rs34344742 chr7:1149288 C/G cg00990874 chr7:1149470 C7orf50 -0.7 -9.21 -0.45 3.93e-18 Bronchopulmonary dysplasia; CRC cis rs12681287 0.604 rs34227066 chr8:87449366 C/T cg27223183 chr8:87520930 FAM82B -0.52 -7.44 -0.38 8.7e-13 Caudate activity during reward; CRC cis rs2739330 0.828 rs2186366 chr22:24254113 A/G cg11060661 chr22:24314208 DDT;DDTL -0.48 -8.37 -0.42 1.64e-15 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs9323205 0.723 rs55980461 chr14:51737434 G/A cg23942311 chr14:51606299 NA -0.5 -5.66 -0.3 3.23e-8 Cancer; CRC cis rs7618501 1.000 rs11130221 chr3:49819102 C/G cg24308560 chr3:49941425 MST1R -0.45 -7.01 -0.36 1.33e-11 Intelligence (multi-trait analysis); CRC cis rs6502050 0.835 rs9904520 chr17:80100117 T/C cg19223190 chr17:80058835 NA 0.4 6.36 0.33 6.88e-10 Life satisfaction; CRC cis rs17401966 0.838 rs946502 chr1:10309279 G/C cg19773385 chr1:10388646 KIF1B -0.68 -11.21 -0.53 6.45e-25 Hepatocellular carcinoma; CRC cis rs11724804 0.532 rs7657611 chr4:880558 G/C cg15105011 chr4:940614 TMEM175 0.57 8.86 0.44 5.27e-17 Primary biliary cholangitis;Limited cutaneous systemic scleroderma; CRC cis rs66573146 0.831 rs1048009 chr4:6988677 G/A cg00086871 chr4:6988644 TBC1D14 0.93 8.97 0.44 2.3e-17 Granulocyte percentage of myeloid white cells; CRC cis rs1008375 0.933 rs6847966 chr4:17634255 G/A cg04450456 chr4:17643702 FAM184B 0.36 5.69 0.3 2.82e-8 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs1552244 0.554 rs2272121 chr3:10047680 A/G cg13047869 chr3:10149882 C3orf24 0.39 5.95 0.31 6.9e-9 Alzheimer's disease; CRC cis rs9302690 0.557 rs223869 chr16:57494992 C/A cg27017172 chr16:57497170 POLR2C 0.66 5.88 0.31 1.01e-8 Blood protein levels; CRC cis rs6933660 0.760 rs1825368 chr6:151775259 C/A cg14416726 chr6:151773293 C6orf211;RMND1 -0.64 -10.01 -0.48 9.04e-21 Menarche (age at onset); CRC cis rs2160860 0.965 rs2543044 chr8:39819087 C/T cg11363097 chr8:39792086 IDO2 -0.36 -5.78 -0.3 1.78e-8 Blood metabolite levels; CRC cis rs6502050 0.835 rs8065556 chr17:80091176 G/C cg11859384 chr17:80120422 CCDC57 -0.38 -5.98 -0.31 5.84e-9 Life satisfaction; CRC cis rs9649213 0.593 rs6947208 chr7:97912204 C/T cg24562669 chr7:97807699 LMTK2 0.45 7.66 0.39 2.06e-13 Prostate cancer (SNP x SNP interaction); CRC cis rs7811142 1.000 rs68116612 chr7:100006493 G/A cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.9 12.31 0.56 6.96e-29 Platelet count; CRC cis rs926938 0.618 rs1286555 chr1:115361896 C/T cg12756093 chr1:115239321 AMPD1 -0.56 -8.18 -0.41 6.16e-15 Autism; CRC cis rs11252926 0.527 rs10904093 chr10:436848 A/G cg16386425 chr10:429943 DIP2C 0.41 5.94 0.31 7.11e-9 Psychosis in Alzheimer's disease; CRC cis rs703842 0.642 rs11536137 chr12:58056426 C/A cg18357645 chr12:58087776 OS9 -0.5 -5.81 -0.3 1.51e-8 Multiple sclerosis; CRC trans rs875971 0.545 rs1065265 chr7:65841203 C/T cg02869306 chr7:64672164 INTS4L1 -0.43 -6.19 -0.32 1.82e-9 Aortic root size; CRC cis rs2806561 0.765 rs681395 chr1:23500314 G/A cg12483005 chr1:23474871 LUZP1 0.51 7.35 0.38 1.62e-12 Height; CRC trans rs4714291 0.802 rs1474870 chr6:39980359 C/T cg02267698 chr19:7991119 CTXN1 0.49 6.82 0.35 4.29e-11 Strep throat; CRC cis rs61332075 0.504 rs7596847 chr2:239321118 T/A cg18131467 chr2:239335373 ASB1 -0.71 -8.87 -0.44 4.89e-17 Lung function (FEV1/FVC); CRC cis rs10221833 0.602 rs355881 chr2:165633716 C/G cg03182029 chr2:165697222 COBLL1 0.49 5.8 0.3 1.56e-8 Response to statin therapy; CRC cis rs7618915 0.547 rs6768697 chr3:52703615 C/T cg18404041 chr3:52824283 ITIH1 -0.44 -9.03 -0.45 1.49e-17 Bipolar disorder; CRC cis rs3218092 1.000 rs3218092 chr6:41906661 A/G cg17623882 chr6:41773611 USP49 0.48 5.65 0.3 3.52e-8 Red cell distribution width; CRC cis rs2629540 0.765 rs7097177 chr10:126539839 A/G cg08799069 chr10:126477246 METTL10 -0.51 -7.31 -0.37 2.02e-12 Cocaine dependence; CRC cis rs79349575 0.783 rs59270107 chr17:47026185 A/T cg00947319 chr17:47005597 UBE2Z -0.33 -5.67 -0.3 3.19e-8 Type 2 diabetes; CRC cis rs2637266 0.519 rs11001805 chr10:78286474 C/T cg18941641 chr10:78392320 NA -0.36 -6.03 -0.32 4.41e-9 Pulmonary function; CRC cis rs73206853 0.841 rs56184938 chr12:110817193 T/C cg12870014 chr12:110450643 ANKRD13A 0.77 8.38 0.42 1.59e-15 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC cis rs7666738 0.830 rs116103936 chr4:98954531 T/C cg05340658 chr4:99064831 C4orf37 0.61 9.54 0.47 3.45e-19 Colonoscopy-negative controls vs population controls; CRC cis rs614226 1.000 rs614226 chr12:120974510 C/T cg27489772 chr12:121021490 NA -0.49 -6.57 -0.34 2e-10 Type 1 diabetes nephropathy; CRC cis rs12824058 0.831 rs11060826 chr12:130809931 G/C cg24838063 chr12:130822603 PIWIL1 0.58 9.77 0.47 5.67e-20 Menopause (age at onset); CRC cis rs9443645 0.901 rs2152951 chr6:79762172 A/G cg09184832 chr6:79620586 NA 0.5 9.45 0.46 6.44e-19 Intelligence (multi-trait analysis); CRC cis rs9287719 0.967 rs728282 chr2:10750303 A/G cg00105475 chr2:10696890 NA 0.45 7.17 0.37 4.87e-12 Prostate cancer; CRC cis rs8180040 0.620 rs9844122 chr3:47108330 C/T cg10298567 chr3:47292165 KIF9 -0.39 -6.02 -0.32 4.64e-9 Colorectal cancer; CRC cis rs7937682 0.889 rs1784787 chr11:111486125 T/A cg09085632 chr11:111637200 PPP2R1B -0.98 -19.21 -0.73 1.09e-55 Primary sclerosing cholangitis; CRC cis rs473651 0.935 rs541128 chr2:239336449 A/G cg21699342 chr2:239360505 ASB1 0.58 10.47 0.5 2.49e-22 Multiple system atrophy; CRC cis rs11123610 0.520 rs12711962 chr2:3717985 C/T cg19052272 chr2:3704530 ALLC -0.62 -7.62 -0.39 2.78e-13 Response to inhaled corticosteroid treatment in asthma (change in FEV1); CRC cis rs7274811 0.744 rs6141411 chr20:32157934 G/A cg07470512 chr20:32255052 NECAB3;C20orf134 -0.47 -6.42 -0.33 4.79e-10 Height; CRC cis rs17767392 0.794 rs61989259 chr14:71733506 T/C cg13720639 chr14:72061746 SIPA1L1 -0.53 -6.42 -0.33 4.67e-10 Mitral valve prolapse; CRC cis rs12681288 0.823 rs2701905 chr8:1003482 T/C cg04851639 chr8:1020857 NA -0.34 -7.19 -0.37 4.26e-12 Schizophrenia; CRC cis rs7647973 0.600 rs13064780 chr3:49274826 T/G cg07636037 chr3:49044803 WDR6 0.83 12.78 0.58 1.18e-30 Menarche (age at onset); CRC cis rs992157 0.835 rs2292551 chr2:219143229 G/A cg04731861 chr2:219085781 ARPC2 0.33 6.95 0.36 2.01e-11 Colorectal cancer; CRC cis rs1348850 0.608 rs2364845 chr2:178226240 T/C cg02961200 chr2:178257176 LOC100130691;AGPS 0.46 6.58 0.34 1.86e-10 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs5769765 0.862 rs9616381 chr22:50312382 G/A cg08270630 chr22:50330655 NA -0.4 -5.61 -0.3 4.4e-8 Schizophrenia; CRC cis rs11628318 0.614 rs7143048 chr14:103119800 C/T cg08075719 chr14:103021372 NA 0.65 7.6 0.39 3.13e-13 Platelet count; CRC cis rs4713118 0.513 rs202908 chr6:28011551 C/G cg25164649 chr6:28176230 NA 0.6 8.51 0.42 6.28e-16 Parkinson's disease; CRC cis rs995000 0.931 rs1629122 chr1:63046578 C/A cg19896129 chr1:63156450 NA -0.43 -6.7 -0.35 8.97e-11 Triglyceride levels; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg11489389 chr3:63849240 ATXN7;THOC7 0.39 6.29 0.33 9.82e-10 Liver disease severity in Alagille syndrome; CRC cis rs6076065 0.548 rs6048742 chr20:23327584 T/C cg11657817 chr20:23433608 CST11 0.57 9.74 0.47 7.08e-20 Facial morphology (factor 15, philtrum width); CRC cis rs853679 0.542 rs6934769 chr6:28090931 A/G cg12273811 chr6:28175739 NA 0.73 9.36 0.46 1.34e-18 Depression; CRC cis rs2760061 0.626 rs672977 chr1:228120288 A/C cg02753203 chr1:228287806 NA -0.66 -10.07 -0.49 5.83e-21 Diastolic blood pressure; CRC cis rs853679 0.517 rs9393888 chr6:28059217 G/C cg21251018 chr6:28226885 NKAPL 0.48 6.22 0.32 1.55e-9 Depression; CRC cis rs921968 0.541 rs17572485 chr2:219296545 C/T cg02176678 chr2:219576539 TTLL4 -0.55 -8.8 -0.44 7.71e-17 Mean corpuscular hemoglobin concentration; CRC trans rs17685 0.735 rs11763339 chr7:75761541 T/C cg19862616 chr7:65841803 NCRNA00174 0.99 18.11 0.71 2.51e-51 Coffee consumption;Coffee consumption (cups per day); CRC cis rs3768617 0.811 rs4366285 chr1:183013672 T/G ch.1.3577855R chr1:183094577 LAMC1 0.61 9.01 0.45 1.67e-17 Fuchs's corneal dystrophy; CRC cis rs780096 0.546 rs715326 chr2:27725761 A/G cg17158414 chr2:27665306 KRTCAP3 0.28 6.0 0.31 5.27e-9 Total body bone mineral density; CRC cis rs10504229 0.593 rs12155520 chr8:58014318 C/T cg02290350 chr8:58132656 NA -0.51 -5.89 -0.31 9.42e-9 Developmental language disorder (linguistic errors); CRC cis rs12541335 0.639 rs13257108 chr8:22165043 T/C cg27266060 chr8:22091797 NA 0.37 6.23 0.32 1.4e-9 Hypertriglyceridemia; CRC cis rs2032447 0.831 rs9467664 chr6:26021813 A/T cg26028573 chr6:26043587 HIST1H2BB 0.51 7.37 0.38 1.39e-12 Intelligence (multi-trait analysis); CRC cis rs13191362 1.000 rs60719662 chr6:163006643 A/C cg06582575 chr6:163149167 PACRG;PARK2 0.73 10.55 0.5 1.3e-22 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs7762018 1.000 rs4716375 chr6:170071218 A/C cg17545662 chr6:170176663 C6orf70 0.53 5.82 0.31 1.39e-8 Thiazide-induced adverse metabolic effects in hypertensive patients; CRC trans rs11165623 0.585 rs6698447 chr1:96999473 C/T cg10631902 chr5:14652156 NA -0.4 -6.83 -0.35 4.13e-11 Hip circumference;Waist circumference; CRC cis rs992157 0.835 rs2045434 chr2:219144498 A/G cg04880052 chr2:219191631 PNKD -0.44 -6.99 -0.36 1.5e-11 Colorectal cancer; CRC cis rs6545883 0.929 rs2593626 chr2:61665184 C/A cg15711740 chr2:61764176 XPO1 -0.45 -6.02 -0.31 4.77e-9 Tuberculosis; CRC cis rs10503871 0.625 rs13275869 chr8:30310335 T/C cg26383811 chr8:30366931 RBPMS 0.48 7.61 0.39 2.97e-13 Metabolite levels (X-11787); CRC cis rs10992471 0.580 rs724102 chr9:95383290 T/C cg14631576 chr9:95140430 CENPP -0.34 -5.85 -0.31 1.21e-8 Visceral adipose tissue/subcutaneous adipose tissue ratio; CRC cis rs9372498 0.505 rs9481811 chr6:118801174 T/C cg01339444 chr6:118972232 C6orf204 0.54 6.01 0.31 5e-9 Diastolic blood pressure; CRC cis rs9733 0.596 rs11204697 chr1:150658971 C/T cg10589385 chr1:150898437 SETDB1 0.28 5.98 0.31 5.86e-9 Tonsillectomy; CRC cis rs4363385 0.693 rs2339487 chr1:152983528 C/T cg25856811 chr1:152973957 SPRR3 -0.25 -6.8 -0.35 4.81e-11 Inflammatory skin disease; CRC cis rs2075064 0.903 rs7034780 chr9:126788935 A/G cg14112217 chr9:126806003 NA 0.39 5.67 0.3 3.12e-8 Waist circumference; CRC cis rs2576037 0.526 rs7234570 chr18:44459656 A/G cg24750912 chr18:44543259 TCEB3CL;KATNAL2 0.29 5.97 0.31 6.3e-9 Personality dimensions; CRC cis rs28374715 0.532 rs28584379 chr15:41670408 C/G cg18705301 chr15:41695430 NDUFAF1 -1.13 -18.76 -0.72 6.3e-54 Ulcerative colitis; CRC cis rs58235267 0.544 rs12478556 chr2:63341711 T/A cg17519650 chr2:63277830 OTX1 0.46 6.4 0.33 5.5e-10 Prostate-specific antigen levels (conditioned on lead SNPs); CRC cis rs1552244 0.882 rs13077641 chr3:10022935 G/A cg16606324 chr3:10149918 C3orf24 0.61 7.98 0.4 2.47e-14 Alzheimer's disease; CRC cis rs7940866 0.804 rs6590540 chr11:130805444 T/C cg12179176 chr11:130786555 SNX19 0.63 9.19 0.45 4.6e-18 Schizophrenia; CRC cis rs4713118 0.621 rs9295756 chr6:28033396 G/T cg12273811 chr6:28175739 NA 0.62 7.96 0.4 2.74e-14 Parkinson's disease; CRC cis rs6594499 0.872 rs6859041 chr5:110435231 G/A cg04022379 chr5:110408740 TSLP 0.47 7.18 0.37 4.62e-12 Allergic disease (asthma, hay fever or eczema); CRC cis rs2013441 1.000 rs2703792 chr17:20166950 G/A cg13482628 chr17:19912719 NA -0.4 -6.22 -0.32 1.47e-9 Obesity-related traits; CRC cis rs67478160 0.584 rs2295147 chr14:104195664 A/G cg01849466 chr14:104193079 ZFYVE21 0.56 10.99 0.52 3.97e-24 Schizophrenia; CRC cis rs9549328 0.731 rs2873371 chr13:113616242 C/T cg24588162 chr13:113633484 MCF2L -0.38 -6.67 -0.35 1.07e-10 Systolic blood pressure; CRC cis rs1448094 0.791 rs10863124 chr12:86352548 A/T cg02569458 chr12:86230093 RASSF9 0.46 7.8 0.39 8.41e-14 Major depressive disorder; CRC cis rs10752881 0.967 rs10911186 chr1:182972542 A/G ch.1.3577855R chr1:183094577 LAMC1 0.87 15.17 0.64 8.86e-40 Colorectal cancer; CRC cis rs62408225 1.000 rs969577 chr6:90982387 T/C cg06866423 chr6:90926672 BACH2 0.51 8.44 0.42 1.01e-15 Eosinophil counts;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC cis rs763014 0.966 rs4247097 chr16:654224 G/A cg09263875 chr16:632152 PIGQ 0.8 13.08 0.58 8.9e-32 Height; CRC cis rs2637266 0.600 rs11591359 chr10:78339907 G/A cg18941641 chr10:78392320 NA -0.36 -6.05 -0.32 3.87e-9 Pulmonary function; CRC cis rs9381040 0.610 rs6940356 chr6:41020360 C/T cg25110423 chr6:41068646 NFYA;LOC221442 -0.38 -5.83 -0.31 1.29e-8 Alzheimer's disease (late onset); CRC cis rs6976053 0.518 rs314358 chr7:100410657 A/G cg20848291 chr7:100343083 ZAN 0.4 6.19 0.32 1.83e-9 Plasminogen activator inhibitor type 1 levels (PAI-1); CRC cis rs4481887 0.504 rs4576682 chr1:248358694 A/T cg00666640 chr1:248458726 OR2T12 0.44 7.07 0.36 9.39e-12 Common traits (Other); CRC cis rs10256972 0.552 rs2949195 chr7:1202705 G/A cg26608667 chr7:1196370 ZFAND2A 0.45 7.21 0.37 3.98e-12 Longevity;Endometriosis; CRC cis rs875971 1.000 rs3735148 chr7:65971009 T/G cg11764359 chr7:65958608 NA 0.63 10.25 0.49 1.39e-21 Aortic root size; CRC cis rs10504229 0.683 rs1495865 chr8:58141160 T/G cg21724239 chr8:58056113 NA 0.49 6.81 0.35 4.75e-11 Developmental language disorder (linguistic errors); CRC cis rs3008870 0.958 rs12143044 chr1:67460054 A/T cg08660285 chr1:67390436 MIER1;WDR78 -1.04 -15.24 -0.64 4.66e-40 Lymphocyte percentage of white cells; CRC cis rs1943345 0.556 rs588956 chr11:82926047 T/C cg07047830 chr11:82868014 PCF11 0.45 6.42 0.33 4.74e-10 Obesity-related traits; CRC cis rs8062405 1.000 rs62036617 chr16:28827498 T/C cg08761264 chr16:28874980 SH2B1 -0.42 -5.66 -0.3 3.26e-8 Cognitive ability (multi-trait analysis);Cognitive ability; CRC cis rs7814319 0.966 rs10112328 chr8:97254372 C/T cg20787634 chr8:97240163 UQCRB 0.55 9.22 0.45 3.54e-18 Lung function (FVC); CRC cis rs9381040 0.610 rs9394758 chr6:41017821 C/T cg04346459 chr6:41068666 NFYA;LOC221442 -0.41 -6.12 -0.32 2.64e-9 Alzheimer's disease (late onset); CRC cis rs7523050 0.643 rs35665867 chr1:109395436 G/A cg08274380 chr1:109419600 GPSM2 0.96 7.0 0.36 1.48e-11 Fat distribution (HIV); CRC cis rs990171 1.000 rs3860444 chr2:103007623 A/G cg03938978 chr2:103052716 IL18RAP 0.47 5.89 0.31 9.5e-9 Lymphocyte counts; CRC cis rs4523957 0.748 rs12603592 chr17:2119818 A/T cg16513277 chr17:2031491 SMG6 -0.51 -8.14 -0.41 8.15e-15 Autism spectrum disorder or schizophrenia;Schizophrenia; CRC cis rs6495122 0.501 rs7167261 chr15:75343807 T/C cg14664628 chr15:75095509 CSK 0.46 6.83 0.35 4.21e-11 Caffeine consumption;Diastolic blood pressure;Coffee consumption; CRC cis rs911119 0.955 rs6048952 chr20:23607257 A/G cg16589663 chr20:23618590 CST3 0.47 6.73 0.35 7.35e-11 Chronic kidney disease; CRC cis rs873946 0.586 rs12783078 chr10:134569706 C/T cg18305652 chr10:134549665 INPP5A 0.48 6.14 0.32 2.42e-9 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CRC cis rs561341 0.505 rs28708703 chr17:30386845 C/G cg19193384 chr17:30244184 NA -0.51 -6.68 -0.35 9.99e-11 Hip circumference adjusted for BMI; CRC cis rs72781680 0.898 rs72788214 chr2:24087621 A/C cg08917208 chr2:24149416 ATAD2B 0.92 9.37 0.46 1.23e-18 Lymphocyte counts; CRC cis rs2976388 0.632 rs2585139 chr8:143808175 C/G cg24046110 chr8:143859143 LYNX1 0.47 8.17 0.41 6.57e-15 Urinary tract infection frequency; CRC cis rs12188164 0.762 rs11745923 chr5:475408 T/G cg16322479 chr5:444228 EXOC3;C5orf55 0.52 8.4 0.42 1.36e-15 Cystic fibrosis severity; CRC cis rs12701220 0.895 rs10262866 chr7:1019536 G/A cg02733842 chr7:1102375 C7orf50 -0.68 -7.74 -0.39 1.2e-13 Bronchopulmonary dysplasia; CRC cis rs2243480 1.000 rs10247526 chr7:65780696 T/G cg25985355 chr7:65971099 NA 0.52 5.83 0.31 1.31e-8 Diabetic kidney disease; CRC cis rs2153535 0.580 rs1410766 chr6:8525360 T/C cg07606381 chr6:8435919 SLC35B3 0.67 10.99 0.52 3.88e-24 Motion sickness; CRC cis rs916888 0.647 rs199523 chr17:44848517 C/A cg01570182 chr17:44337453 NA -0.73 -9.23 -0.45 3.3e-18 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs7043114 0.525 rs1133908 chr9:95068046 C/T cg14631576 chr9:95140430 CENPP -0.3 -5.76 -0.3 1.92e-8 Height; CRC cis rs9457247 0.967 rs2769346 chr6:167370999 A/G cg23791538 chr6:167370224 RNASET2 0.38 5.98 0.31 5.76e-9 Crohn's disease; CRC cis rs875971 0.540 rs1723268 chr7:65473080 A/C cg02869306 chr7:64672164 INTS4L1 -0.35 -5.85 -0.31 1.19e-8 Aortic root size; CRC cis rs9467711 0.659 rs66941101 chr6:26530376 C/T cg12315302 chr6:26189340 HIST1H4D 0.99 6.93 0.36 2.22e-11 Autism spectrum disorder or schizophrenia; CRC cis rs4148883 0.504 rs2000864 chr4:100123776 A/C cg13256891 chr4:100009986 ADH5 0.42 6.35 0.33 7.1e-10 Alcohol dependence; CRC cis rs4253772 0.530 rs6008774 chr22:46755298 C/G cg24881330 chr22:46731750 TRMU 0.68 8.07 0.41 1.34e-14 LDL cholesterol;Cholesterol, total; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg17466598 chr12:98988242 SLC25A3 0.41 6.07 0.32 3.62e-9 Intelligence (multi-trait analysis); CRC cis rs10751667 0.621 rs7394862 chr11:927500 T/C cg06064525 chr11:970664 AP2A2 -0.33 -6.65 -0.34 1.24e-10 Alzheimer's disease (late onset); CRC cis rs6674176 0.660 rs2108202 chr1:44395786 A/G cg15962314 chr1:44399869 ARTN -0.31 -5.97 -0.31 6.29e-9 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Cognitive ability; CRC trans rs3931020 0.720 rs927904 chr1:75260328 A/G cg08796741 chr22:46663681 TTC38 0.49 6.28 0.33 1.07e-9 Resistin levels; CRC cis rs6582630 0.555 rs2004152 chr12:38478951 C/T cg13010199 chr12:38710504 ALG10B 0.47 5.91 0.31 8.63e-9 Drug-induced liver injury (flucloxacillin); CRC cis rs561341 0.941 rs112569713 chr17:30271738 C/T cg12193833 chr17:30244370 NA -0.62 -7.94 -0.4 3.33e-14 Hip circumference adjusted for BMI; CRC cis rs1552244 0.572 rs17032440 chr3:10169819 A/C cg02579736 chr3:10068473 FANCD2;CIDECP -1.0 -11.59 -0.54 2.72e-26 Alzheimer's disease; CRC cis rs8060686 0.516 rs7184821 chr16:68270229 T/C cg26727032 chr16:67993705 SLC12A4 -0.65 -10.01 -0.48 9.41e-21 HDL cholesterol;Metabolic syndrome; CRC cis rs950169 0.845 rs4106951 chr15:84833394 C/G cg11189052 chr15:85197271 WDR73 0.63 8.95 0.44 2.7e-17 Schizophrenia; CRC trans rs2710642 0.962 rs7557501 chr2:63086639 C/T cg05376469 chr2:102649931 NA -0.38 -6.33 -0.33 7.97e-10 LDL cholesterol levels;LDL cholesterol; CRC cis rs1045714 0.895 rs73043180 chr7:2645972 C/T cg24848437 chr7:2645542 IQCE 0.58 6.13 0.32 2.5e-9 Urate levels in lean individuals; CRC cis rs9916302 0.851 rs677888 chr17:37461018 T/G cg15445000 chr17:37608096 MED1 -0.34 -6.78 -0.35 5.64e-11 Glomerular filtration rate (creatinine); CRC cis rs9929218 0.551 rs9888942 chr16:68727572 A/G cg01251360 chr16:68772225 CDH1 -0.24 -5.89 -0.31 9.53e-9 Colorectal cancer; CRC cis rs7192750 0.562 rs152838 chr16:72105702 C/T cg14768367 chr16:72042858 DHODH 0.75 6.3 0.33 9.32e-10 LDL cholesterol levels;Total cholesterol levels; CRC cis rs9326248 0.520 rs236919 chr11:117095361 A/G cg26566898 chr11:117069891 TAGLN 0.32 6.83 0.35 4.1e-11 Blood protein levels; CRC cis rs12449964 0.524 rs4925094 chr17:17569012 C/T cg24612305 chr17:17875800 TOM1L2;LRRC48 -0.39 -6.04 -0.32 4.15e-9 Coronary artery disease or ischemic stroke; CRC trans rs459571 0.959 rs2520100 chr9:136918137 A/T cg09836344 chr4:1243392 C4orf42;CTBP1 -0.81 -11.47 -0.53 7.28e-26 Platelet distribution width; CRC trans rs3733585 0.638 rs28715627 chr4:9958140 T/A cg26043149 chr18:55253948 FECH -0.5 -7.65 -0.39 2.21e-13 Cleft plate (environmental tobacco smoke interaction); CRC cis rs2456568 0.867 rs72962810 chr11:93663619 A/G cg26875233 chr11:93583750 C11orf90 -0.34 -6.66 -0.34 1.17e-10 Response to serotonin reuptake inhibitors in major depressive disorder; CRC cis rs2976388 0.590 rs11785290 chr8:143814849 A/G cg04969067 chr8:143858791 LYNX1 -0.43 -6.77 -0.35 5.89e-11 Urinary tract infection frequency; CRC cis rs79839061 0.563 rs55728587 chr4:843674 G/A cg07828340 chr4:882639 GAK 1.12 10.78 0.51 2.04e-23 Intelligence (multi-trait analysis); CRC cis rs6500602 0.627 rs860891 chr16:4586529 C/T cg06139259 chr16:4526053 HMOX2;NMRAL1 -0.43 -5.96 -0.31 6.64e-9 Schizophrenia; CRC cis rs4722166 0.630 rs1581497 chr7:22779503 C/A cg05472934 chr7:22766657 IL6 0.76 12.37 0.56 4.12e-29 Lung cancer; CRC cis rs62229266 0.804 rs2835259 chr21:37425302 T/C cg12218747 chr21:37451666 NA -0.45 -7.75 -0.39 1.18e-13 Mitral valve prolapse; CRC trans rs2303319 0.504 rs12465645 chr2:162437639 A/G cg14875682 chr5:52083620 ITGA1;PELO -0.75 -6.01 -0.31 5.03e-9 Cognitive function; CRC cis rs2108622 0.668 rs62106153 chr19:15978507 C/T cg13772218 chr19:15982569 NA 0.48 6.72 0.35 8.16e-11 Circulating phylloquinone levels;Vitamin E levels;Acenocoumarol maintenance dosage;Response to Vitamin E supplementation;Metabolite levels;Warfarin maintenance dose; CRC cis rs2985684 0.894 rs4581611 chr14:50043520 A/T cg04989706 chr14:50066350 PPIL5 -0.62 -8.7 -0.43 1.61e-16 Carotid intima media thickness; CRC cis rs375066 0.599 rs10412955 chr19:44354868 T/C cg19542119 chr19:44331823 ZNF283 0.4 5.61 0.3 4.24e-8 Breast cancer; CRC cis rs853679 0.517 rs9295761 chr6:28147987 A/G cg18032046 chr6:28092343 ZSCAN16 -0.5 -5.72 -0.3 2.36e-8 Depression; CRC cis rs4654899 0.758 rs6426665 chr1:21382205 T/C cg02927042 chr1:21476669 EIF4G3 -0.4 -6.27 -0.33 1.12e-9 Superior frontal gyrus grey matter volume; CRC cis rs11758351 1.000 rs17598927 chr6:26184640 C/G cg08260959 chr6:26240920 HIST1H4F 0.39 5.97 0.31 6.1e-9 Gout;Renal underexcretion gout; CRC cis rs7584330 0.826 rs7604315 chr2:238381729 C/G cg11271282 chr2:238384023 NA 0.46 5.97 0.31 6.3e-9 Prostate cancer; CRC cis rs12190007 0.573 rs13202383 chr6:169826544 A/G cg15038512 chr6:170123185 PHF10 -0.39 -6.05 -0.32 3.91e-9 Obesity-related traits; CRC cis rs3008870 0.755 rs12562761 chr1:67396739 C/T cg08660285 chr1:67390436 MIER1;WDR78 0.54 7.6 0.39 3.13e-13 Lymphocyte percentage of white cells; CRC cis rs300703 0.935 rs300749 chr2:208143 G/T cg21211680 chr2:198530 NA 0.85 8.23 0.41 4.37e-15 Blood protein levels; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg03001875 chr1:234614834 TARBP1 0.48 6.65 0.34 1.26e-10 Anxiety disorder; CRC cis rs7923609 0.967 rs10761766 chr10:65190327 G/A cg08743896 chr10:65200160 JMJD1C -0.42 -6.01 -0.31 4.94e-9 Educational attainment;Liver enzyme levels (alkaline phosphatase); CRC cis rs12476592 0.636 rs262493 chr2:63845066 G/T cg10828910 chr2:63850056 LOC388955 0.45 5.68 0.3 2.97e-8 Childhood ear infection; CRC cis rs6570726 0.905 rs396492 chr6:145816180 C/G cg23711669 chr6:146136114 FBXO30 0.62 10.62 0.51 7.79e-23 Lobe attachment (rater-scored or self-reported); CRC cis rs6752107 0.967 rs56227616 chr2:234157741 T/C cg07618928 chr2:234183455 ATG16L1;SCARNA5 0.64 10.63 0.51 6.96e-23 Crohn's disease;Inflammatory bowel disease; CRC cis rs4862750 0.872 rs6836781 chr4:187899701 G/A cg10295955 chr4:187884368 NA -1.06 -28.72 -0.85 1.21e-91 Lobe attachment (rater-scored or self-reported); CRC cis rs1129187 0.755 rs9471988 chr6:42944773 T/C cg27588902 chr6:42928151 GNMT -0.4 -7.23 -0.37 3.44e-12 Alzheimer's disease in APOE e4+ carriers; CRC cis rs6089584 0.507 rs6061989 chr20:60627893 C/T cg23262073 chr20:60523788 NA -0.42 -6.63 -0.34 1.38e-10 Body mass index; CRC cis rs10782582 0.593 rs1412717 chr1:76125471 C/T cg10523679 chr1:76189770 ACADM -0.4 -5.66 -0.3 3.28e-8 Daytime sleep phenotypes; CRC cis rs11212617 0.967 rs419716 chr11:108221099 G/T cg14761454 chr11:108092087 ATM;NPAT -0.4 -6.08 -0.32 3.42e-9 Response to metformin in type 2 diabetes (glycemic); CRC cis rs9292777 0.535 rs1031168 chr5:40381620 T/C cg09067459 chr5:40385259 NA 0.45 6.97 0.36 1.73e-11 Crohn's disease;Multiple sclerosis; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg17436946 chr4:39699568 UBE2K 0.39 6.46 0.34 3.85e-10 Liver disease severity in Alagille syndrome; CRC cis rs10789491 1.000 rs2083485 chr1:47170091 G/C cg15501359 chr1:47185051 KIAA0494 0.75 8.91 0.44 3.68e-17 Response to hepatitis C treatment; CRC cis rs12936587 0.576 rs8073975 chr17:17555631 G/T cg24612305 chr17:17875800 TOM1L2;LRRC48 -0.38 -5.7 -0.3 2.73e-8 Hip circumference;Coronary artery disease or large artery stroke;Coronary heart disease;Coronary artery disease; CRC cis rs9487051 1.000 rs9400272 chr6:109616762 A/G cg01475377 chr6:109611718 NA -0.44 -7.93 -0.4 3.44e-14 Reticulocyte fraction of red cells; CRC cis rs2304069 0.955 rs4288106 chr5:149394872 A/G cg22760475 chr5:149380129 HMGXB3;TIGD6 0.86 10.02 0.48 8.62e-21 HIV-1 control; CRC cis rs9584850 0.834 rs7985565 chr13:99113471 C/G cg07423050 chr13:99094983 FARP1 0.45 6.41 0.33 5.15e-10 Neuroticism; CRC trans rs877282 1.000 rs11253361 chr10:770387 T/C cg22713356 chr15:30763199 NA 1.11 14.08 0.61 1.5e-35 Uric acid levels; CRC cis rs1003719 1.000 rs2835608 chr21:38493455 A/G cg10648535 chr21:38446584 PIGP;TTC3 0.5 6.83 0.35 4.1e-11 Eye color traits; CRC cis rs651907 0.557 rs34376498 chr3:101480156 C/T cg11279151 chr3:101281821 RG9MTD1 -0.55 -7.51 -0.38 5.54e-13 Colorectal cancer; CRC cis rs6500395 1.000 rs4785535 chr16:48707659 A/G cg04672837 chr16:48644449 N4BP1 -0.45 -6.63 -0.34 1.38e-10 Response to tocilizumab in rheumatoid arthritis; CRC cis rs4664293 0.836 rs7567818 chr2:160602697 C/T cg08347373 chr2:160653686 CD302 -0.47 -7.43 -0.38 9.32e-13 Monocyte percentage of white cells; CRC cis rs2949837 0.581 rs1543270 chr7:46006323 C/T cg06713098 chr7:45960367 IGFBP3 0.44 6.85 0.35 3.65e-11 Sitting height ratio; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg17140673 chr4:111117400 ELOVL6 0.45 6.73 0.35 7.75e-11 Response to antipsychotic treatment; CRC trans rs45509595 0.841 rs370155 chr6:27782031 T/G cg06606381 chr12:133084897 FBRSL1 -0.74 -6.49 -0.34 3.16e-10 Breast cancer; CRC cis rs7215564 0.818 rs112155856 chr17:78594573 A/T cg09596252 chr17:78655493 RPTOR 0.59 5.77 0.3 1.82e-8 Myopia (pathological); CRC cis rs4474465 0.920 rs7396701 chr11:78202699 A/C cg27205649 chr11:78285834 NARS2 0.46 5.83 0.31 1.35e-8 Alzheimer's disease (survival time); CRC cis rs2295359 1.000 rs963427 chr1:67609347 A/G cg03340356 chr1:67600835 NA 0.25 5.82 0.31 1.42e-8 Psoriasis; CRC cis rs13064411 0.696 rs36054418 chr3:113204762 G/T cg10517650 chr3:113235015 CCDC52 -0.41 -7.18 -0.37 4.55e-12 Response to simvastatin treatment (PCSK9 protein level change); CRC cis rs11148252 0.574 rs61958118 chr13:53170226 C/T cg20354231 chr13:53171401 NA -0.48 -7.75 -0.39 1.16e-13 Lewy body disease; CRC cis rs1552244 0.882 rs67895180 chr3:10026079 T/C cg08888203 chr3:10149979 C3orf24 0.62 8.23 0.41 4.29e-15 Alzheimer's disease; CRC cis rs1395 0.922 rs13404327 chr2:27519153 G/T cg23587288 chr2:27483067 SLC30A3 -0.33 -5.66 -0.3 3.31e-8 Blood metabolite levels; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg19419581 chr17:79482410 NA 0.48 7.04 0.36 1.15e-11 Response to antipsychotic treatment; CRC cis rs6502050 0.835 rs4789668 chr17:80161990 C/T cg13198984 chr17:80129470 CCDC57 0.49 8.6 0.43 3.33e-16 Life satisfaction; CRC cis rs7119 0.604 rs2271397 chr15:77907775 T/C cg27398640 chr15:77910606 LINGO1 0.42 7.9 0.4 4.24e-14 Type 2 diabetes; CRC cis rs9435341 0.965 rs55924375 chr1:107566690 C/A cg14828511 chr1:107599125 PRMT6 0.47 6.45 0.34 3.91e-10 Facial morphology (factor 21, depth of nasal alae); CRC cis rs769267 1.000 rs12985655 chr19:19442434 G/A cg03709012 chr19:19516395 GATAD2A -0.67 -10.3 -0.49 9.29e-22 Tonsillectomy; CRC cis rs2404602 0.655 rs4886507 chr15:77209694 T/C cg03037974 chr15:76606532 NA 0.68 11.13 0.52 1.22e-24 Blood metabolite levels; CRC cis rs7923609 0.934 rs10822153 chr10:65056813 C/A cg08743896 chr10:65200160 JMJD1C -0.4 -5.72 -0.3 2.44e-8 Educational attainment;Liver enzyme levels (alkaline phosphatase); CRC cis rs798554 0.679 rs1639066 chr7:2892972 A/G cg19717773 chr7:2847554 GNA12 -0.45 -6.42 -0.33 4.72e-10 Height; CRC cis rs10789491 1.000 rs7516616 chr1:47186274 A/G cg15501359 chr1:47185051 KIAA0494 -0.7 -7.84 -0.4 6.44e-14 Response to hepatitis C treatment; CRC cis rs5758659 0.652 rs5758553 chr22:42431429 G/A cg15557168 chr22:42548783 NA -0.34 -5.62 -0.3 4.08e-8 Cognitive function; CRC cis rs55823223 0.648 rs936393 chr17:73847613 A/G cg14829360 chr17:73884958 NA -0.46 -7.09 -0.36 8.22e-12 Psoriasis; CRC cis rs9560113 0.573 rs1888304 chr13:112242454 A/G cg10483660 chr13:112241077 NA 0.65 12.61 0.57 5.2e-30 Menarche (age at onset); CRC cis rs7666738 0.791 rs13128640 chr4:99003918 A/C cg05340658 chr4:99064831 C4orf37 0.61 9.54 0.47 3.44e-19 Colonoscopy-negative controls vs population controls; CRC cis rs919433 0.963 rs7582736 chr2:198170342 A/G cg10820045 chr2:198174542 NA -0.55 -9.29 -0.46 2.12e-18 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC cis rs11677416 1.000 rs1800794 chr2:113543273 G/A cg27083787 chr2:113543245 IL1A 0.58 7.53 0.38 4.94e-13 Response to antipsychotic treatment in schizophrenia (working memory); CRC cis rs73195822 0.614 rs1123852 chr12:111221408 C/G cg12870014 chr12:110450643 ANKRD13A 0.66 7.0 0.36 1.41e-11 Itch intensity from mosquito bite; CRC cis rs11971779 0.680 rs4398844 chr7:139043139 G/A cg23387468 chr7:139079360 LUC7L2 0.41 7.11 0.36 7.28e-12 Diisocyanate-induced asthma; CRC cis rs7618915 0.547 rs12496634 chr3:52709259 A/C cg05573699 chr3:52720067 GNL3;PBRM1 -0.47 -6.77 -0.35 6.02e-11 Bipolar disorder; CRC cis rs950169 1.000 rs12902672 chr15:84716986 G/A cg03959625 chr15:84868606 LOC388152 0.41 6.08 0.32 3.27e-9 Schizophrenia; CRC cis rs6502050 0.529 rs35585236 chr17:80116641 T/C cg09264619 chr17:80180166 NA -0.34 -5.71 -0.3 2.52e-8 Life satisfaction; CRC cis rs7584330 0.554 rs6706729 chr2:238398580 T/C cg08992911 chr2:238395768 MLPH 0.61 6.09 0.32 3.07e-9 Prostate cancer; CRC cis rs7666738 0.830 rs6854594 chr4:99065312 A/T cg05340658 chr4:99064831 C4orf37 0.61 9.43 0.46 7.6e-19 Colonoscopy-negative controls vs population controls; CRC cis rs3806843 1.000 rs6870764 chr5:140171790 C/T cg16607685 chr5:140181889 PCDHA2;PCDHA1;PCDHA3 -0.26 -5.97 -0.31 6.06e-9 Depressive symptoms (multi-trait analysis); CRC cis rs17818399 0.620 rs7598578 chr2:46857085 T/C cg26688816 chr2:46740690 ATP6V1E2 -0.42 -6.25 -0.33 1.28e-9 Height; CRC cis rs7552404 0.655 rs1146646 chr1:76265500 G/A cg05598546 chr1:76251766 SNORD45C;RABGGTB 0.49 5.83 0.31 1.35e-8 Blood metabolite levels;Acylcarnitine levels; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg11601748 chr5:443197 C5orf55;EXOC3 0.42 6.16 0.32 2.17e-9 Intelligence (multi-trait analysis); CRC cis rs9311474 0.508 rs11718420 chr3:52611413 T/C cg18404041 chr3:52824283 ITIH1 -0.41 -8.69 -0.43 1.71e-16 Electroencephalogram traits; CRC cis rs875971 1.000 rs2420168 chr7:65630631 C/G cg18912574 chr7:65842487 NCRNA00174 -0.37 -6.5 -0.34 3e-10 Aortic root size; CRC cis rs875971 0.522 rs56028712 chr7:65466565 C/T cg18876405 chr7:65276391 NA 0.67 12.19 0.56 1.9e-28 Aortic root size; CRC cis rs3213545 0.700 rs2260399 chr12:121469653 C/T cg02403541 chr12:121454288 C12orf43 0.44 6.91 0.36 2.55e-11 Subjective well-being;Cardiovascular disease risk factors; CRC cis rs7762018 0.607 rs7759404 chr6:170135728 A/G cg17545662 chr6:170176663 C6orf70 0.57 6.45 0.34 3.99e-10 Thiazide-induced adverse metabolic effects in hypertensive patients; CRC cis rs668210 0.793 rs1192184 chr11:65773382 A/G cg02202077 chr11:65769826 EIF1AD;BANF1 -0.55 -6.99 -0.36 1.51e-11 Cerebrospinal fluid biomarker levels; CRC trans rs7615952 0.546 rs111812401 chr3:125361495 G/A cg07211511 chr3:129823064 LOC729375 -0.59 -6.9 -0.36 2.74e-11 Blood pressure (smoking interaction); CRC cis rs360798 0.512 rs1906198 chr2:62946658 C/T cg17519650 chr2:63277830 OTX1 0.43 5.93 0.31 7.52e-9 Coronary artery disease; CRC cis rs9807989 0.507 rs3213732 chr2:102998279 A/G cg03938978 chr2:103052716 IL18RAP 0.59 10.12 0.49 3.77e-21 Asthma; CRC cis rs7246967 0.673 rs59621958 chr19:22940659 C/T cg08271804 chr19:22816896 ZNF492 0.38 5.82 0.31 1.41e-8 Bronchopulmonary dysplasia; CRC cis rs13108904 0.539 rs13141992 chr4:1340765 C/T cg21620606 chr4:1342894 KIAA1530 0.51 8.03 0.4 1.77e-14 Obesity-related traits; CRC cis rs28374715 0.578 rs17730888 chr15:41637547 A/G cg18705301 chr15:41695430 NDUFAF1 -1.04 -18.5 -0.71 6.73e-53 Ulcerative colitis; CRC cis rs425277 0.606 rs262664 chr1:2083537 G/C cg04315214 chr1:2043799 PRKCZ -0.39 -6.64 -0.34 1.27e-10 Height; CRC cis rs1018836 0.884 rs9643307 chr8:91625257 A/C cg16814680 chr8:91681699 NA -0.75 -11.86 -0.55 3e-27 Ejection fraction in Tripanosoma cruzi seropositivity; CRC cis rs1046896 0.514 rs67735447 chr17:80823042 G/T cg03160526 chr17:80928410 B3GNTL1 0.59 8.18 0.41 6.07e-15 Glycated hemoglobin levels; CRC cis rs9291683 0.588 rs3796842 chr4:9995851 A/T cg11266682 chr4:10021025 SLC2A9 0.48 10.31 0.49 8.81e-22 Bone mineral density; CRC cis rs9787249 0.957 rs11809515 chr1:40205326 C/A cg01941586 chr1:40203715 PPIE -0.46 -6.37 -0.33 6.26e-10 Blood protein levels; CRC cis rs861020 0.630 rs599649 chr1:210003402 T/C cg09163369 chr1:210001066 C1orf107 0.41 5.76 0.3 1.97e-8 Orofacial clefts; CRC cis rs75422866 0.867 rs73104138 chr12:48086085 C/T cg14736327 chr12:48174669 SLC48A1 -0.79 -6.01 -0.31 4.92e-9 Pneumonia; CRC cis rs2991971 0.967 rs10789465 chr1:45971759 T/C cg15605315 chr1:45957053 TESK2 0.42 6.76 0.35 6.3e-11 High light scatter reticulocyte count; CRC cis rs2932538 0.961 rs3795820 chr1:113163042 C/A cg22162597 chr1:113214053 CAPZA1 -0.71 -9.93 -0.48 1.75e-20 Systolic blood pressure;Diastolic blood pressure;Hypertension;Blood pressure; CRC cis rs317689 0.718 rs160827 chr12:69770147 G/A cg20891283 chr12:69753455 YEATS4 0.66 8.41 0.42 1.26e-15 Response to diuretic therapy; CRC cis rs13108904 0.935 rs4974575 chr4:1252028 A/G cg20092199 chr4:1342459 KIAA1530 0.38 6.61 0.34 1.53e-10 Obesity-related traits; CRC cis rs1552244 1.000 rs56394721 chr3:10150795 A/G cg18598329 chr3:10140678 FANCD2;C3orf24 -0.89 -11.87 -0.55 2.63e-27 Alzheimer's disease; CRC cis rs11098499 0.863 rs3775849 chr4:120450908 G/C cg24375607 chr4:120327624 NA 0.47 7.05 0.36 1.06e-11 Corneal astigmatism; CRC cis rs6062302 0.522 rs2282157 chr20:62227180 C/G cg09650180 chr20:62225654 GMEB2 -0.5 -6.67 -0.35 1.07e-10 Glioblastoma; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg14751398 chr6:20402153 E2F3 0.48 6.35 0.33 7.17e-10 Thyroid stimulating hormone; CRC cis rs7829975 0.714 rs4840362 chr8:8670082 C/G cg08975724 chr8:8085496 FLJ10661 -0.46 -6.96 -0.36 1.84e-11 Mood instability; CRC cis rs9381040 0.610 rs2268195 chr6:41024340 G/A cg04346459 chr6:41068666 NFYA;LOC221442 -0.41 -6.14 -0.32 2.43e-9 Alzheimer's disease (late onset); CRC cis rs1865760 1.000 rs7770139 chr6:25925823 A/G cg17691542 chr6:26056736 HIST1H1C 0.55 8.19 0.41 5.97e-15 Height; CRC cis rs6866344 0.568 rs10516147 chr5:178094484 A/G cg03877680 chr5:178157825 ZNF354A 0.57 7.1 0.36 7.84e-12 Neutrophil percentage of white cells; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg23237097 chr1:160278129 COPA 0.43 6.75 0.35 6.56e-11 Liver disease severity in Alagille syndrome; CRC cis rs7605827 0.930 rs10172344 chr2:15521591 A/G cg19274914 chr2:15703543 NA 0.37 5.62 0.3 3.99e-8 Educational attainment (years of education); CRC cis rs4588572 0.601 rs6867673 chr5:77779125 A/G cg11446398 chr5:77624930 NA 0.45 6.03 0.32 4.45e-9 Triglycerides; CRC cis rs10106298 0.846 rs2436936 chr8:103677723 C/A cg10187029 chr8:103597600 NA 0.44 6.14 0.32 2.37e-9 Schizophrenia; CRC cis rs11098499 0.863 rs1480940 chr4:120457682 T/C cg24375607 chr4:120327624 NA 0.48 7.25 0.37 3.03e-12 Corneal astigmatism; CRC trans rs35110281 0.686 rs162399 chr21:44950020 G/A cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.5 8.25 0.41 3.94e-15 Mean corpuscular volume; CRC cis rs4909189 1.000 rs4909189 chr7:158136986 A/T cg23298862 chr7:158159286 PTPRN2 -0.48 -7.32 -0.37 1.89e-12 Response to amphetamines; CRC cis rs2224391 1.000 rs2753246 chr6:5261845 A/G cg09085698 chr6:5261316 LYRM4;FARS2 -0.44 -5.61 -0.3 4.22e-8 Height; CRC cis rs2739330 0.734 rs2000467 chr22:24241533 C/T cg04234412 chr22:24373322 LOC391322 0.61 8.99 0.44 1.97e-17 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs11758351 0.660 rs1997768 chr6:26217728 C/T cg08260959 chr6:26240920 HIST1H4F 0.36 5.95 0.31 6.92e-9 Gout;Renal underexcretion gout; CRC cis rs4713118 0.869 rs6914924 chr6:27711530 C/T cg19041857 chr6:27730383 NA -0.41 -6.0 -0.31 5.3300000000000004e-09 Parkinson's disease; CRC cis rs6504622 0.557 rs197912 chr17:44989888 A/T cg16759221 chr17:45003025 GOSR2 0.58 8.92 0.44 3.39e-17 Orofacial clefts; CRC cis rs473651 0.935 rs508483 chr2:239339709 T/C cg08773314 chr2:239334832 ASB1 0.37 8.57 0.43 4.09e-16 Multiple system atrophy; CRC cis rs10504229 0.593 rs17192845 chr8:58053339 C/T cg24829409 chr8:58192753 C8orf71 -0.68 -8.29 -0.42 2.99e-15 Developmental language disorder (linguistic errors); CRC cis rs9322817 0.617 rs9391242 chr6:105231257 G/A cg02098413 chr6:105308735 HACE1 -0.43 -8.22 -0.41 4.66e-15 Thyroid stimulating hormone; CRC cis rs4713118 0.955 rs34752872 chr6:27683244 A/T cg26587870 chr6:27730563 NA -0.42 -6.22 -0.32 1.54e-9 Parkinson's disease; CRC cis rs1799949 1.000 rs33994002 chr17:41328818 T/A cg05368731 chr17:41323189 NBR1 0.69 10.45 0.5 2.95e-22 Menopause (age at onset); CRC trans rs7395662 0.526 rs4882001 chr11:48546675 A/G cg03929089 chr4:120376271 NA -0.48 -6.93 -0.36 2.24e-11 HDL cholesterol; CRC cis rs11690935 0.610 rs3770458 chr2:172651287 C/T cg13550731 chr2:172543902 DYNC1I2 0.7 10.19 0.49 2.28e-21 Schizophrenia; CRC cis rs7605378 0.964 rs2689763 chr2:200689555 G/A cg23649088 chr2:200775458 C2orf69 0.56 7.94 0.4 3.21e-14 Osteoporosis; CRC cis rs7666738 0.830 rs10017557 chr4:98983969 G/A cg05340658 chr4:99064831 C4orf37 0.6 9.41 0.46 8.57e-19 Colonoscopy-negative controls vs population controls; CRC cis rs2404602 0.583 rs2176623 chr15:76568579 C/T cg00316803 chr15:76480434 C15orf27 -0.38 -6.41 -0.33 5.03e-10 Blood metabolite levels; CRC cis rs3824867 1.000 rs3824867 chr11:47468569 A/G cg20307385 chr11:47447363 PSMC3 0.44 5.62 0.3 4.14e-8 Mean corpuscular hemoglobin; CRC cis rs10540 1.000 rs12794284 chr11:477623 C/T cg21784768 chr11:537496 LRRC56 -0.63 -5.99 -0.31 5.56e-9 Body mass index; CRC cis rs62064224 0.614 rs2286645 chr17:30696292 C/T cg18200150 chr17:30822561 MYO1D 0.44 8.45 0.42 9.7e-16 Schizophrenia; CRC trans rs7301826 0.627 rs7315707 chr12:131272819 A/G cg04557695 chr7:92466167 CDK6 0.47 6.38 0.33 5.95e-10 Plasma plasminogen activator levels; CRC trans rs10504229 0.861 rs67042991 chr8:58191749 G/C cg04077850 chr5:125800366 GRAMD3 0.37 6.27 0.33 1.15e-9 Developmental language disorder (linguistic errors); CRC cis rs13064411 0.542 rs13082603 chr3:113223362 T/C cg18753928 chr3:113234510 CCDC52 -0.53 -8.13 -0.41 8.8e-15 Response to simvastatin treatment (PCSK9 protein level change); CRC cis rs7615952 0.576 rs17523380 chr3:125802874 C/T cg02772935 chr3:125709198 NA -0.5 -6.54 -0.34 2.4e-10 Blood pressure (smoking interaction); CRC cis rs4930561 0.714 rs11228151 chr11:67949371 C/G cg04465784 chr11:67976953 SUV420H1 -0.3 -5.98 -0.31 5.78e-9 Breast cancer in childhood cancer survivors;IgG glycosylation; CRC cis rs6484504 0.600 rs7122895 chr11:31346620 G/C cg14844989 chr11:31128820 NA 0.34 6.09 0.32 3.19e-9 Red blood cell count; CRC cis rs651907 0.557 rs12629658 chr3:101356535 A/G cg11279151 chr3:101281821 RG9MTD1 -0.57 -7.71 -0.39 1.46e-13 Colorectal cancer; CRC cis rs7927771 0.524 rs2869024 chr11:47674101 G/A cg20307385 chr11:47447363 PSMC3 -0.47 -7.02 -0.36 1.29e-11 Subjective well-being; CRC cis rs6964587 1.000 rs6950470 chr7:91680641 G/A cg17063962 chr7:91808500 NA 0.83 14.87 0.63 1.25e-38 Breast cancer; CRC cis rs2346160 0.867 rs2989556 chr6:167704404 T/A cg04673565 chr6:167680447 NA -0.41 -6.83 -0.35 4.21e-11 Parental extreme longevity (95 years and older); CRC cis rs4285028 0.747 rs1463736 chr3:121400725 G/A cg20356878 chr3:121714668 ILDR1 -0.43 -6.09 -0.32 3.08e-9 Multiple sclerosis; CRC cis rs2243480 1.000 rs1964692 chr7:65454183 G/A cg12463550 chr7:65579703 CRCP 0.65 6.2 0.32 1.67e-9 Diabetic kidney disease; CRC trans rs75246769 0.500 rs111234753 chr7:145673182 A/G cg14916917 chr5:81574294 RPS23 0.92 6.34 0.33 7.48e-10 Facial morphology (factor 10, width of nasal floor); CRC cis rs1322512 1.000 rs2758780 chr6:153008108 A/G cg03415253 chr6:152958462 SYNE1 0.4 6.04 0.32 4.14e-9 Tonometry; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg16427967 chr20:30697241 TM9SF4 0.47 6.78 0.35 5.45e-11 Intelligence (multi-trait analysis); CRC cis rs1448094 0.512 rs7957170 chr12:86243282 A/G cg02569458 chr12:86230093 RASSF9 0.42 7.24 0.37 3.17e-12 Major depressive disorder; CRC cis rs853679 0.517 rs9348793 chr6:28084189 G/A cg12172441 chr6:28176163 NA 0.62 7.27 0.37 2.56e-12 Depression; CRC cis rs28386778 0.897 rs8066754 chr17:61816590 T/C cg11494091 chr17:61959527 GH2 0.58 9.87 0.48 2.75e-20 Prudent dietary pattern; CRC cis rs7829975 0.714 rs4841040 chr8:8654527 T/C cg08975724 chr8:8085496 FLJ10661 0.45 6.79 0.35 5.16e-11 Mood instability; CRC cis rs7772486 0.536 rs9373467 chr6:145955605 C/T cg05347473 chr6:146136440 FBXO30 0.49 6.94 0.36 2.08e-11 Lobe attachment (rater-scored or self-reported); CRC cis rs17401966 0.931 rs11585794 chr1:10443867 G/A cg19773385 chr1:10388646 KIF1B -0.69 -11.04 -0.52 2.5e-24 Hepatocellular carcinoma; CRC cis rs7937682 0.924 rs499750 chr11:111513645 T/G cg19812747 chr11:111475976 SIK2 -0.58 -9.68 -0.47 1.18e-19 Primary sclerosing cholangitis; CRC cis rs2070488 0.775 rs7649984 chr3:38570221 C/T cg01465620 chr3:38496096 LOC100128640;ACVR2B -0.67 -10.89 -0.51 8.89e-24 Electrocardiographic conduction measures; CRC cis rs875971 0.545 rs2460427 chr7:65619205 T/C cg03233332 chr7:66118400 NA 0.44 6.14 0.32 2.41e-9 Aortic root size; CRC cis rs7762018 0.891 rs7764839 chr6:170146351 C/A cg19338460 chr6:170058176 WDR27 -0.69 -7.6 -0.39 3.03e-13 Thiazide-induced adverse metabolic effects in hypertensive patients; CRC cis rs4132509 0.793 rs34477525 chr1:243966454 T/A cg21452805 chr1:244014465 NA 0.54 7.3 0.37 2.22e-12 RR interval (heart rate); CRC cis rs4319547 0.656 rs10734918 chr12:122921512 A/C cg23029597 chr12:123009494 RSRC2 -0.54 -6.71 -0.35 8.41e-11 Body mass index; CRC cis rs6952808 0.582 rs11763870 chr7:2027448 T/C cg21782813 chr7:2030301 MAD1L1 -0.47 -8.64 -0.43 2.5e-16 Bipolar disorder and schizophrenia; CRC cis rs501120 0.584 rs1704218 chr10:44729599 C/T cg09554077 chr10:44749378 NA 0.66 7.12 0.37 6.69e-12 Coronary artery disease;Coronary heart disease; CRC cis rs25422 0.878 rs55894300 chr6:118982076 T/A cg22561889 chr6:118971681 C6orf204 0.55 6.71 0.35 8.37e-11 Renal cell carcinoma; CRC cis rs9517313 0.592 rs61969458 chr13:99177633 A/G cg20487152 chr13:99095054 FARP1 -0.45 -6.48 -0.34 3.26e-10 Neuroticism; CRC cis rs9457247 0.508 rs7760495 chr6:167506795 C/T cg07741184 chr6:167504864 NA 0.37 6.54 0.34 2.42e-10 Crohn's disease; CRC cis rs4728142 0.564 rs11767711 chr7:128651832 C/T cg06630958 chr7:128577819 IRF5 -0.35 -5.78 -0.3 1.74e-8 Inflammatory bowel disease;Systemic lupus erythematosus;Ulcerative colitis; CRC cis rs694739 0.536 rs11231740 chr11:64046641 C/T cg05555928 chr11:63887634 MACROD1 0.45 7.63 0.39 2.5e-13 Alopecia areata;Crohn's disease;Psoriasis vulgaris; CRC trans rs9929218 0.954 rs17715762 chr16:68828250 T/G cg04657470 chr2:198365150 HSPE1;HSPD1 -0.77 -11.12 -0.52 1.33e-24 Colorectal cancer; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg08695707 chr1:197871847 C1orf53 0.49 6.88 0.35 2.94e-11 Response to antipsychotic treatment; CRC cis rs2280018 0.963 rs11075255 chr16:15166232 A/G cg27102117 chr16:15229624 NA 0.38 6.61 0.34 1.54e-10 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid);Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CRC cis rs17401966 0.898 rs11582123 chr1:10303942 A/T cg19773385 chr1:10388646 KIF1B -0.68 -10.92 -0.52 6.84e-24 Hepatocellular carcinoma; CRC cis rs68170813 0.559 rs10953531 chr7:106827867 A/G cg02696742 chr7:106810147 HBP1 0.62 6.95 0.36 1.94e-11 Coronary artery disease; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg23010568 chr17:568212 VPS53 -0.38 -6.07 -0.32 3.61e-9 Liver disease severity in Alagille syndrome; CRC cis rs6142102 0.923 rs6059586 chr20:32540501 G/A cg08999081 chr20:33150536 PIGU 0.4 6.18 0.32 1.93e-9 Skin pigmentation; CRC cis rs7044106 0.762 rs10760110 chr9:123412563 A/G cg09419670 chr9:123605666 PSMD5;LOC253039 -0.67 -10.35 -0.5 6.34e-22 Hip circumference adjusted for BMI; CRC cis rs1950626 0.699 rs12880855 chr14:101468382 C/T cg02351406 chr14:101447389 SNORD114-20;SNORD114-21 0.97 15.7 0.65 7.45e-42 Pelvic organ prolapse (moderate/severe); CRC cis rs919433 0.680 rs7582536 chr2:198436103 C/T cg10820045 chr2:198174542 NA -0.38 -6.51 -0.34 2.89e-10 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC cis rs10504229 0.953 rs66676208 chr8:58173866 C/T cg24829409 chr8:58192753 C8orf71 -0.68 -11.34 -0.53 2.27e-25 Developmental language disorder (linguistic errors); CRC cis rs972578 1.000 rs5759075 chr22:43389090 G/C cg01576275 chr22:43409880 NA -0.49 -7.91 -0.4 3.96e-14 Mean platelet volume; CRC cis rs2228479 0.571 rs62052183 chr16:89966921 C/A cg19635926 chr16:89946313 TCF25 0.66 6.83 0.35 4.23e-11 Skin colour saturation; CRC cis rs11997175 0.603 rs7464072 chr8:33776973 G/A cg04338863 chr8:33670619 NA 0.4 6.07 0.32 3.56e-9 Body mass index; CRC cis rs2836974 0.863 rs8128026 chr21:40533702 T/C cg11890956 chr21:40555474 PSMG1 1.08 19.11 0.73 2.82e-55 Cognitive function; CRC cis rs73206853 0.764 rs7299230 chr12:110618512 A/T cg12870014 chr12:110450643 ANKRD13A 0.82 10.2 0.49 2.1e-21 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC cis rs8014204 0.575 rs1045430 chr14:75130235 T/G cg03030879 chr14:75389066 RPS6KL1 -0.44 -6.86 -0.35 3.42e-11 Caffeine consumption; CRC cis rs35762459 1 rs35762459 chr11:8844653 T/TA cg00186954 chr11:8933980 ST5;C11orf17 -0.44 -7.32 -0.37 1.94e-12 Immature fraction of reticulocytes; CRC cis rs5753618 0.509 rs2413033 chr22:31574213 A/G cg22777020 chr22:31556080 RNF185 -0.52 -6.05 -0.32 3.91e-9 Colorectal cancer; CRC cis rs35110281 0.720 rs162374 chr21:44927089 T/C cg01579765 chr21:45077557 HSF2BP 0.35 6.62 0.34 1.47e-10 Mean corpuscular volume; CRC cis rs989128 0.600 rs73338243 chr17:48631324 T/C cg24438145 chr17:48624694 SPATA20 0.44 6.26 0.33 1.2e-9 Type 2 diabetes; CRC trans rs1005277 0.563 rs2505216 chr10:38482830 T/C cg11292332 chr7:45801988 SEPT13 -0.38 -6.83 -0.35 4.14e-11 Extrinsic epigenetic age acceleration; CRC cis rs12692738 0.526 rs355835 chr2:165618530 G/A cg03182029 chr2:165697222 COBLL1 0.48 5.66 0.3 3.32e-8 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);Waist-to-hip ratio adjusted for BMI in non-smokers;Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction);Waist-to-hip ratio adjusted for body mass index; CRC cis rs11229555 0.874 rs12800710 chr11:58314540 C/T cg15696309 chr11:58395628 NA -0.95 -12.87 -0.58 5.82e-31 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; CRC cis rs4901869 0.864 rs12891575 chr14:59334342 T/A cg02291164 chr14:59296302 NA 0.34 6.17 0.32 1.99e-9 Panic disorder; CRC cis rs9470366 0.545 rs4711457 chr6:36633160 T/C cg08179530 chr6:36648295 CDKN1A -0.55 -8.11 -0.41 1.01e-14 QRS duration; CRC cis rs1707322 1.000 rs10890377 chr1:46406594 G/A cg03146154 chr1:46216737 IPP 0.5 7.07 0.36 9.58e-12 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs6952808 0.792 rs4421257 chr7:1955152 T/C cg22963979 chr7:1858916 MAD1L1 -0.45 -6.99 -0.36 1.56e-11 Bipolar disorder and schizophrenia; CRC cis rs7089973 0.628 rs11196953 chr10:116607707 A/G cg23260525 chr10:116636907 FAM160B1 0.35 8.11 0.41 1.04e-14 Bipolar disorder or attention deficit hyperactivity disorder; CRC cis rs2243480 0.908 rs313822 chr7:65573939 G/A cg18252515 chr7:66147081 NA -1.18 -13.88 -0.61 8.21e-35 Diabetic kidney disease; CRC cis rs6502050 0.761 rs12150321 chr17:80061558 T/C cg22110888 chr17:80059540 CCDC57 -0.42 -6.54 -0.34 2.37e-10 Life satisfaction; CRC cis rs4481887 1.000 rs7553333 chr1:248493956 C/G cg13385794 chr1:248469461 NA 0.39 6.63 0.34 1.35e-10 Common traits (Other); CRC cis rs55883249 0.957 rs17453675 chr2:9754407 A/G cg23886495 chr2:9695866 ADAM17 0.52 5.97 0.31 6.19e-9 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; CRC trans rs9467711 0.659 rs66941101 chr6:26530376 C/T cg06606381 chr12:133084897 FBRSL1 -1.07 -7.41 -0.38 1.09e-12 Autism spectrum disorder or schizophrenia; CRC cis rs4481887 0.927 rs10157089 chr1:248488157 A/G cg13385794 chr1:248469461 NA 0.4 7.1 0.36 7.96e-12 Common traits (Other); CRC cis rs911119 0.913 rs6048923 chr20:23578206 C/T cg16589663 chr20:23618590 CST3 0.56 6.89 0.36 2.89e-11 Chronic kidney disease; CRC cis rs9926296 0.585 rs8058009 chr16:89856439 G/A cg04287289 chr16:89883240 FANCA 0.7 10.89 0.51 8.31e-24 Vitiligo; CRC cis rs9467711 0.538 rs35942482 chr6:26444938 T/A cg16898833 chr6:26189333 HIST1H4D 0.94 7.65 0.39 2.25e-13 Autism spectrum disorder or schizophrenia; CRC cis rs904251 0.647 rs2776908 chr6:37434857 T/C cg25019722 chr6:37503610 NA -0.43 -6.2 -0.32 1.71e-9 Cognitive performance; CRC cis rs55702914 0.628 rs3731570 chr2:198317783 C/T cg10820045 chr2:198174542 NA 0.33 5.84 0.31 1.22e-8 Major depression and alcohol dependence; CRC cis rs875971 0.545 rs73136346 chr7:65566082 A/G cg03233332 chr7:66118400 NA 0.45 6.18 0.32 1.92e-9 Aortic root size; CRC trans rs7615952 0.512 rs2979334 chr3:125358824 G/A cg21747405 chr11:67723411 NA -0.58 -9.13 -0.45 6.88e-18 Blood pressure (smoking interaction); CRC cis rs4665809 1.000 rs6546744 chr2:26302161 A/G cg22920501 chr2:26401640 FAM59B -0.53 -7.18 -0.37 4.7e-12 Gut microbiome composition (summer); CRC cis rs4662945 0.603 rs10496678 chr2:130262209 C/T cg05903289 chr2:130345205 NA -0.42 -8.16 -0.41 7.21e-15 Response to cytidine analogues (gemcitabine); CRC cis rs7178572 0.743 rs62009090 chr15:77837055 T/G cg22256960 chr15:77711686 NA -0.62 -9.15 -0.45 6.06e-18 Type 2 diabetes; CRC cis rs1881797 1.000 rs1881796 chr1:247688931 G/A cg18198730 chr1:247681584 NA 0.55 8.54 0.43 5.12e-16 Acute lymphoblastic leukemia (childhood); CRC cis rs7618915 0.547 rs62255362 chr3:52699741 C/G cg18099408 chr3:52552593 STAB1 -0.44 -7.22 -0.37 3.66e-12 Bipolar disorder; CRC cis rs6586163 1.000 rs6586163 chr10:90752018 A/C cg13456138 chr10:90753195 FAS -0.44 -6.87 -0.35 3.31e-11 Chronic lymphocytic leukemia; CRC cis rs6502050 0.835 rs7221544 chr17:80087337 C/T cg02741985 chr17:80059408 CCDC57 -0.44 -7.2 -0.37 4.16e-12 Life satisfaction; CRC cis rs7586879 0.765 rs11683429 chr2:25120733 T/A cg22495460 chr2:25135724 ADCY3 -0.88 -14.97 -0.64 5.2e-39 Body mass index; CRC cis rs6952808 1.000 rs6957894 chr7:1887362 G/A cg04267008 chr7:1944627 MAD1L1 -0.69 -10.03 -0.48 7.84e-21 Bipolar disorder and schizophrenia; CRC trans rs13046373 0.905 rs4816372 chr21:32077414 A/T cg10473508 chr5:172068142 NEURL1B -0.41 -6.03 -0.32 4.31e-9 HDL cholesterol; CRC cis rs2204008 0.774 rs7305085 chr12:38263511 C/T cg26384229 chr12:38710491 ALG10B 0.69 9.22 0.45 3.69e-18 Bladder cancer; CRC cis rs9916302 0.645 rs1053651 chr17:37822311 A/C cg00129232 chr17:37814104 STARD3 -0.69 -12.23 -0.56 1.36e-28 Glomerular filtration rate (creatinine); CRC cis rs10504229 0.954 rs114134184 chr8:58181969 G/A cg02725872 chr8:58115012 NA -0.38 -6.43 -0.33 4.44e-10 Developmental language disorder (linguistic errors); CRC trans rs11098499 0.863 rs6835635 chr4:120458867 A/G cg25214090 chr10:38739885 LOC399744 0.64 9.97 0.48 1.28e-20 Corneal astigmatism; CRC cis rs7493 0.901 rs17883318 chr7:94958312 G/A cg04155289 chr7:94953770 PON1 -0.53 -7.28 -0.37 2.4e-12 Yu-Zhi constitution type in type 2 diabetes; CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg24508409 chr1:112298175 DDX20;C1orf183 0.37 6.06 0.32 3.73e-9 Obesity-related traits; CRC cis rs34375054 0.526 rs7302475 chr12:125677886 T/C cg25124228 chr12:125621409 AACS -0.58 -8.18 -0.41 6.22e-15 Post bronchodilator FEV1/FVC ratio; CRC trans rs12660387 1.000 rs62415786 chr6:65254384 G/A cg13393512 chr9:135749454 C9orf98 0.53 6.1 0.32 2.91e-9 Schizophrenia; CRC cis rs13191362 0.935 rs66635391 chr6:162964577 G/A cg21926612 chr6:163149169 PACRG;PARK2 0.82 10.41 0.5 3.86e-22 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs12682352 0.715 rs332039 chr8:8723651 C/G cg08975724 chr8:8085496 FLJ10661 0.39 5.63 0.3 3.94e-8 Neuroticism; CRC cis rs561341 1.000 rs55978022 chr17:30275937 T/C cg19193384 chr17:30244184 NA -0.65 -7.5 -0.38 6.06e-13 Hip circumference adjusted for BMI; CRC cis rs10540 0.730 rs34690033 chr11:492677 G/C cg03352830 chr11:487213 PTDSS2 0.66 7.64 0.39 2.36e-13 Body mass index; CRC cis rs4466137 0.909 rs4466136 chr5:82985576 T/G cg16102102 chr5:83017553 HAPLN1 -0.54 -7.88 -0.4 4.93e-14 Prostate cancer; CRC cis rs748404 0.697 rs564946 chr15:43556272 A/G cg02155558 chr15:43621948 ADAL;LCMT2 0.42 6.29 0.33 9.83e-10 Lung cancer; CRC cis rs116095464 0.681 rs10060016 chr5:241100 T/C cg22496380 chr5:211416 CCDC127 -0.91 -10.44 -0.5 3.16e-22 Breast cancer; CRC cis rs1577917 1.000 rs12201741 chr6:86602619 G/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.51 -6.81 -0.35 4.57e-11 Response to antipsychotic treatment; CRC cis rs8060686 0.641 rs8058690 chr16:68136622 T/G cg08314208 chr16:67682810 RLTPR -0.49 -5.88 -0.31 1.01e-8 HDL cholesterol;Metabolic syndrome; CRC trans rs10983614 1.000 rs7867776 chr9:120072627 A/G cg11829371 chr17:981724 ABR 0.44 6.39 0.33 5.66e-10 Survival in pancreatic cancer; CRC cis rs9911578 1.000 rs1631237 chr17:56734695 A/G cg12560992 chr17:57184187 TRIM37 0.91 16.63 0.68 1.66e-45 Intelligence (multi-trait analysis); CRC cis rs2882667 0.964 rs11958050 chr5:138301828 A/G cg09476006 chr5:138032270 NA 0.54 9.38 0.46 1.13e-18 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs9393692 0.905 rs989134 chr6:26336224 A/C cg05868516 chr6:26286170 HIST1H4H 0.39 5.68 0.3 3.02e-8 Educational attainment; CRC cis rs394563 0.934 rs384334 chr6:149796172 C/G cg03678062 chr6:149772716 ZC3H12D -0.35 -6.14 -0.32 2.42e-9 Dupuytren's disease; CRC cis rs7208859 0.623 rs8075341 chr17:29136565 A/G cg13385521 chr17:29058706 SUZ12P 0.74 8.44 0.42 9.97e-16 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs7412746 0.611 rs4509581 chr1:150774465 A/G cg18016565 chr1:150552671 MCL1 0.42 5.85 0.31 1.19e-8 Melanoma; CRC cis rs10911363 0.571 rs6424897 chr1:183419203 T/C cg09173681 chr1:183549694 NCF2 -0.76 -10.7 -0.51 4.02e-23 Systemic lupus erythematosus; CRC cis rs28386778 0.897 rs1062788 chr17:61896127 C/G cg23090583 chr17:61904693 PSMC5;FTSJ3 1.05 20.68 0.75 1.83e-61 Prudent dietary pattern; CRC cis rs9311474 0.629 rs7639267 chr3:52568805 G/T cg07507251 chr3:52567010 NT5DC2 0.52 8.25 0.41 3.79e-15 Electroencephalogram traits; CRC cis rs7615952 0.599 rs67566088 chr3:125768973 C/A cg02772935 chr3:125709198 NA -0.49 -5.77 -0.3 1.81e-8 Blood pressure (smoking interaction); CRC cis rs3772130 0.923 rs7649092 chr3:121561950 C/A cg20356878 chr3:121714668 ILDR1 0.52 8.21 0.41 5.11e-15 Cognitive performance; CRC trans rs4692589 0.531 rs12650424 chr4:170975204 T/C cg08679238 chr3:46449100 CCRL2 -0.49 -6.28 -0.33 1.1e-9 Anxiety disorder; CRC cis rs7552404 1.000 rs7524467 chr1:76194054 C/G cg22875332 chr1:76189707 ACADM 0.69 9.41 0.46 8.7e-19 Blood metabolite levels;Acylcarnitine levels; CRC cis rs2032447 0.869 rs199752 chr6:26012875 C/T cg27635394 chr6:26043820 HIST1H2BB 0.44 6.36 0.33 6.86e-10 Intelligence (multi-trait analysis); CRC cis rs10504229 0.861 rs116964504 chr8:58185354 A/C cg05313129 chr8:58192883 C8orf71 -0.47 -6.99 -0.36 1.49e-11 Developmental language disorder (linguistic errors); CRC cis rs4819052 0.851 rs2838837 chr21:46665988 C/T cg02159808 chr21:46707872 POFUT2;LOC642852 0.51 6.65 0.34 1.21e-10 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs13191362 0.507 rs1079020 chr6:163066596 C/T cg06582575 chr6:163149167 PACRG;PARK2 -0.55 -8.26 -0.41 3.61e-15 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs514406 0.760 rs1242198 chr1:53352016 G/A cg08859206 chr1:53392774 SCP2 -0.56 -9.02 -0.45 1.64e-17 Monocyte count; CRC cis rs9549367 0.789 rs3850451 chr13:113905812 C/G cg00898013 chr13:113819073 PROZ -0.47 -6.54 -0.34 2.29e-10 Platelet distribution width; CRC cis rs10504073 0.631 rs341813 chr8:50039916 T/C cg00325661 chr8:49890786 NA 0.46 8.23 0.41 4.37e-15 Blood metabolite ratios; CRC cis rs372883 0.648 rs4817279 chr21:30638285 T/C cg08807101 chr21:30365312 RNF160 -0.56 -7.76 -0.39 1.07e-13 Pancreatic cancer; CRC cis rs7487075 0.619 rs10880973 chr12:46853209 C/A cg22049899 chr12:47219821 SLC38A4 0.31 5.78 0.3 1.72e-8 Itch intensity from mosquito bite; CRC trans rs1005277 0.540 rs4934907 chr10:38015230 A/C cg23533926 chr12:111358616 MYL2 -0.44 -6.45 -0.34 3.95e-10 Extrinsic epigenetic age acceleration; CRC cis rs3751196 0.710 rs17034639 chr12:104217799 C/T cg02344784 chr12:104178138 NT5DC3 0.71 7.54 0.38 4.58e-13 Sense of smell; CRC cis rs1539053 0.932 rs12718425 chr1:58105213 G/A cg20292791 chr1:58089357 DAB1 -0.32 -5.68 -0.3 3.04e-8 Plasma omega-6 polyunsaturated fatty acid levels (arachidonic acid); CRC cis rs6570726 0.935 rs374000 chr6:145855290 C/T cg05347473 chr6:146136440 FBXO30 0.38 6.11 0.32 2.84e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs9381040 0.610 rs9367094 chr6:41017860 T/C cg04346459 chr6:41068666 NFYA;LOC221442 -0.41 -6.12 -0.32 2.64e-9 Alzheimer's disease (late onset); CRC cis rs3026101 0.671 rs56019636 chr17:5297551 A/G cg25236894 chr17:5323110 RPAIN;NUP88 0.42 6.84 0.35 3.98e-11 Body mass index; CRC cis rs7618915 0.501 rs2164885 chr3:52731269 T/C cg08222913 chr3:52553049 STAB1 -0.33 -6.11 -0.32 2.86e-9 Bipolar disorder; CRC cis rs4713118 0.527 rs35949862 chr6:28115367 A/G cg06470822 chr6:28175283 NA 1.03 13.59 0.6 1.04e-33 Parkinson's disease; CRC cis rs6570726 1.000 rs444564 chr6:145859795 G/C cg23711669 chr6:146136114 FBXO30 0.71 12.36 0.56 4.22e-29 Lobe attachment (rater-scored or self-reported); CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg08862778 chr1:11322643 MTOR 0.5 6.7 0.35 9.15e-11 Thyroid stimulating hormone; CRC cis rs9926296 0.656 rs11861084 chr16:89875710 G/T cg27121462 chr16:89883253 FANCA -0.42 -6.49 -0.34 3.23e-10 Vitiligo; CRC cis rs7666738 0.606 rs4699611 chr4:99097492 T/G cg05340658 chr4:99064831 C4orf37 0.48 6.9 0.36 2.67e-11 Colonoscopy-negative controls vs population controls; CRC cis rs10744422 1.000 rs4993320 chr12:123338092 T/C cg25930673 chr12:123319894 HIP1R -0.61 -6.4 -0.33 5.25e-10 Schizophrenia; CRC cis rs2153535 0.580 rs1932284 chr6:8477694 A/T cg21535247 chr6:8435926 SLC35B3 0.5 7.52 0.38 5.18e-13 Motion sickness; CRC cis rs7769051 0.522 rs34688576 chr6:133118214 C/T cg22852734 chr6:133119734 C6orf192 1.13 8.45 0.42 9.49e-16 Type 2 diabetes nephropathy; CRC cis rs7618915 0.547 rs2336542 chr3:52710636 A/G cg18404041 chr3:52824283 ITIH1 -0.43 -8.74 -0.43 1.21e-16 Bipolar disorder; CRC cis rs67311347 1.000 rs28434528 chr3:40484893 A/G cg09455208 chr3:40491958 NA 0.43 8.72 0.43 1.36e-16 Renal cell carcinoma; CRC cis rs2976388 0.590 rs10110970 chr8:143820410 G/C cg15511327 chr8:143859410 LYNX1 -0.39 -6.52 -0.34 2.6e-10 Urinary tract infection frequency; CRC cis rs7224685 0.501 rs781853 chr17:3953083 T/C cg09695851 chr17:3907499 NA 0.78 14.47 0.62 4.59e-37 Type 2 diabetes; CRC cis rs4285028 0.731 rs2332035 chr3:121715432 C/T cg11130432 chr3:121712080 ILDR1 -0.51 -6.72 -0.35 8.01e-11 Multiple sclerosis; CRC cis rs2949837 0.655 rs11977526 chr7:46008110 G/A cg06713098 chr7:45960367 IGFBP3 0.49 7.5 0.38 6.07e-13 Sitting height ratio; CRC cis rs1552244 1.000 rs17032295 chr3:10086680 C/T cg13047869 chr3:10149882 C3orf24 0.55 7.79 0.39 8.72e-14 Alzheimer's disease; CRC cis rs7727544 0.735 rs273913 chr5:131661156 A/G cg07395648 chr5:131743802 NA -0.4 -6.2 -0.32 1.69e-9 Blood metabolite levels; CRC cis rs9911578 0.967 rs4598970 chr17:57076893 T/A cg05425664 chr17:57184151 TRIM37 0.52 7.92 0.4 3.71e-14 Intelligence (multi-trait analysis); CRC cis rs875971 0.862 rs7783779 chr7:65796626 A/G cg00343986 chr7:65444356 GUSB -0.45 -6.22 -0.32 1.47e-9 Aortic root size; CRC cis rs10751667 0.666 rs10902239 chr11:946484 A/G ch.11.42038R chr11:967971 AP2A2 -0.57 -9.84 -0.48 3.36e-20 Alzheimer's disease (late onset); CRC cis rs10779751 1.000 rs11121711 chr1:11317661 A/T cg08854313 chr1:11322531 MTOR 0.7 10.05 0.48 6.48e-21 Body mass index; CRC cis rs9908102 0.740 rs8071615 chr17:12914535 G/T cg26162695 chr17:12921313 ELAC2 0.4 5.63 0.3 3.82e-8 Schizophrenia; CRC cis rs7312933 0.703 rs12370778 chr12:42599696 T/A cg19980929 chr12:42632907 YAF2 0.44 6.56 0.34 2.14e-10 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CRC cis rs4332037 0.539 rs55773130 chr7:2070554 T/C cg25834613 chr7:1915315 MAD1L1 -0.41 -5.82 -0.31 1.38e-8 Bipolar disorder; CRC cis rs4474465 0.790 rs7932315 chr11:78214878 G/A cg27205649 chr11:78285834 NARS2 0.47 5.84 0.31 1.23e-8 Alzheimer's disease (survival time); CRC cis rs6952808 0.582 rs871925 chr7:2047875 G/A cg14004847 chr7:1930337 MAD1L1 0.43 6.14 0.32 2.38e-9 Bipolar disorder and schizophrenia; CRC cis rs9420 0.922 rs35808061 chr11:57547000 T/C cg23127183 chr11:57508653 C11orf31 -0.52 -7.12 -0.37 6.68e-12 Schizophrenia; CRC cis rs2120019 1.000 rs7173833 chr15:75369618 C/T cg11632617 chr15:75315747 PPCDC -0.52 -7.44 -0.38 9.1e-13 Blood trace element (Zn levels); CRC cis rs951366 0.617 rs823075 chr1:205774897 C/T cg23034840 chr1:205782522 SLC41A1 0.57 8.08 0.41 1.22e-14 Menarche (age at onset); CRC cis rs801193 1.000 rs2003301 chr7:66147656 G/C cg00343986 chr7:65444356 GUSB -0.5 -7.4 -0.38 1.18e-12 Aortic root size; CRC cis rs2075371 0.796 rs10954440 chr7:134005657 C/T cg20476274 chr7:133979776 SLC35B4 0.68 11.5 0.54 5.71e-26 Mean platelet volume; CRC cis rs8010344 0.685 rs11627032 chr14:93104072 T/C cg26948596 chr14:93078627 RIN3 -0.45 -6.14 -0.32 2.42e-9 Post bronchodilator FEV1/FVC ratio; CRC cis rs57994353 0.759 rs35873563 chr9:139324029 C/T cg14119001 chr9:139324193 INPP5E -0.53 -7.53 -0.38 4.82e-13 Eosinophil counts;Cutaneous squamous cell carcinoma; CRC cis rs12451471 0.620 rs11150846 chr17:78098520 C/T cg21238619 chr17:78079768 GAA -0.34 -5.72 -0.3 2.35e-8 Plateletcrit;Mean corpuscular hemoglobin concentration; CRC cis rs1862618 0.613 rs252889 chr5:56227069 C/A cg20203395 chr5:56204925 C5orf35 -0.59 -8.0 -0.4 2.16e-14 Initial pursuit acceleration; CRC cis rs7107174 1.000 rs1567890 chr11:78101700 T/C cg02023728 chr11:77925099 USP35 0.47 7.25 0.37 2.92e-12 Testicular germ cell tumor; CRC cis rs4665809 1.000 rs2384322 chr2:26291146 C/G cg26119090 chr2:26468346 HADHA;HADHB -0.66 -8.18 -0.41 6.44e-15 Gut microbiome composition (summer); CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg13661497 chr9:5110940 JAK2 -0.37 -6.03 -0.32 4.44e-9 Obesity-related traits; CRC cis rs9916302 0.904 rs8065879 chr17:37515978 G/A cg03013999 chr17:37608204 MED1 -0.47 -7.39 -0.38 1.19e-12 Glomerular filtration rate (creatinine); CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg05318427 chr2:85199320 KCMF1 -0.54 -6.63 -0.34 1.36e-10 Diisocyanate-induced asthma; CRC cis rs1267303 0.563 rs2486163 chr1:47004680 T/C cg25110126 chr1:46999211 NA 0.56 8.31 0.42 2.55e-15 Monobrow; CRC cis rs910316 1.000 rs11845639 chr14:75570293 C/T cg03030879 chr14:75389066 RPS6KL1 -0.49 -7.83 -0.4 6.79e-14 Height; CRC cis rs9846480 0.598 rs6439807 chr3:138074001 G/C cg25476813 chr3:138050155 TXNDC6 -0.38 -5.63 -0.3 3.95e-8 Whole-brain volume (Alzheimer's disease interaction); CRC cis rs4819052 0.851 rs2838865 chr21:46712299 C/T cg02159808 chr21:46707872 POFUT2;LOC642852 0.54 7.11 0.36 7.27e-12 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs2836974 0.533 rs4817999 chr21:40554355 C/A cg11644478 chr21:40555479 PSMG1 -0.7 -11.48 -0.53 7.06e-26 Cognitive function; CRC trans rs2727020 0.729 rs2299650 chr11:49174007 A/C cg21153622 chr11:89784906 NA -0.45 -7.39 -0.38 1.22e-12 Coronary artery disease; CRC cis rs5758659 0.652 rs133300 chr22:42389839 A/G cg04733989 chr22:42467013 NAGA 0.4 5.63 0.3 3.78e-8 Cognitive function; CRC trans rs8002861 0.967 rs9533690 chr13:44480598 T/C cg17145862 chr1:211918768 LPGAT1 0.77 15.93 0.66 9.13e-43 Leprosy; CRC cis rs909002 0.800 rs7549590 chr1:32109849 G/A cg13919466 chr1:32135498 COL16A1 -0.32 -6.14 -0.32 2.44e-9 Intelligence (multi-trait analysis); CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg21658946 chr16:69364455 COG8;PDF 0.43 6.01 0.31 4.89e-9 Anxiety disorder; CRC cis rs8060686 0.545 rs11043 chr16:68262958 G/A cg26727032 chr16:67993705 SLC12A4 -0.62 -8.03 -0.4 1.77e-14 HDL cholesterol;Metabolic syndrome; CRC cis rs889312 0.500 rs33328 chr5:56143419 T/C cg03609598 chr5:56110824 MAP3K1 -0.41 -5.66 -0.3 3.23e-8 Breast cancer;Breast cancer (early onset); CRC trans rs4843747 0.671 rs72818540 chr16:88078988 C/T cg26811252 chr16:29126840 RRN3P2 0.68 9.29 0.46 2.14e-18 Menopause (age at onset); CRC cis rs950027 0.620 rs1719246 chr15:45625479 T/A cg10760299 chr15:45669010 GATM 0.36 5.63 0.3 3.95e-8 Response to fenofibrate (adiponectin levels); CRC cis rs9649213 0.593 rs12704983 chr7:97927045 G/A cg00277769 chr7:97922759 BAIAP2L1 -0.61 -10.67 -0.51 5.02e-23 Prostate cancer (SNP x SNP interaction); CRC cis rs1113500 0.897 rs10785832 chr1:108638899 G/A cg06207961 chr1:108661230 NA 0.39 5.75 0.3 2.07e-8 Growth-regulated protein alpha levels; CRC cis rs853679 0.550 rs1233699 chr6:28169158 A/T cg03623178 chr6:28175578 NA 1.03 15.75 0.66 4.97e-42 Depression; CRC cis rs2108622 0.727 rs3093207 chr19:15988658 T/C cg13772218 chr19:15982569 NA 0.48 6.75 0.35 6.72e-11 Circulating phylloquinone levels;Vitamin E levels;Acenocoumarol maintenance dosage;Response to Vitamin E supplementation;Metabolite levels;Warfarin maintenance dose; CRC cis rs9487051 0.714 rs7774377 chr6:109602443 G/A cg21918786 chr6:109611834 NA -0.43 -7.51 -0.38 5.72e-13 Reticulocyte fraction of red cells; CRC cis rs11628318 0.713 rs1998419 chr14:103050397 C/G cg23461800 chr14:103021989 NA -0.75 -9.88 -0.48 2.49e-20 Platelet count; CRC cis rs754466 0.580 rs11002289 chr10:79532580 G/A cg17075019 chr10:79541650 NA -0.94 -16.88 -0.68 1.75e-46 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs11168351 0.927 rs7971880 chr12:48391055 C/T cg21466736 chr12:48725269 NA -0.5 -7.56 -0.38 3.95e-13 Bipolar disorder and schizophrenia; CRC cis rs2115630 0.691 rs2292462 chr15:85200754 G/T cg12501888 chr15:85177176 SCAND2 -0.49 -8.36 -0.42 1.8e-15 P wave terminal force; CRC cis rs910316 0.646 rs11546525 chr14:75537381 C/T cg11812906 chr14:75593930 NEK9 0.51 7.1 0.36 7.95e-12 Height; CRC cis rs3751196 0.808 rs17034642 chr12:104218928 A/C cg02344784 chr12:104178138 NT5DC3 0.71 7.55 0.38 4.35e-13 Sense of smell; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg18342900 chr16:46865048 C16orf87 0.48 6.43 0.33 4.6e-10 Thyroid stimulating hormone; CRC cis rs7584330 0.554 rs77956735 chr2:238399130 C/T cg14458575 chr2:238380390 NA 0.81 10.27 0.49 1.22e-21 Prostate cancer; CRC cis rs4700695 0.841 rs152935 chr5:65358593 A/G cg21114390 chr5:65439923 SFRS12 -0.66 -7.1 -0.36 7.94e-12 Facial morphology (factor 19); CRC cis rs55823223 0.564 rs4572466 chr17:73846314 A/C cg14829360 chr17:73884958 NA -0.47 -7.37 -0.38 1.39e-12 Psoriasis; CRC cis rs75920871 0.528 rs11600552 chr11:116900947 T/C cg20608306 chr11:116969690 SIK3 -0.32 -6.12 -0.32 2.69e-9 Subjective well-being; CRC cis rs12477438 1.000 rs12477438 chr2:99841085 T/G cg14399236 chr2:99771627 LIPT1;TSGA10 -0.66 -8.07 -0.41 1.38e-14 Chronic sinus infection; CRC cis rs4975709 0.589 rs4975707 chr5:1864028 C/T cg12288994 chr5:1860383 NA 0.38 6.84 0.35 3.85e-11 Cardiovascular disease risk factors; CRC cis rs1552244 1.000 rs9879080 chr3:10084224 C/T cg10729496 chr3:10149963 C3orf24 0.5 6.78 0.35 5.69e-11 Alzheimer's disease; CRC cis rs8031584 0.578 rs1088473 chr15:31139298 A/G cg14829155 chr15:31115871 NA 0.65 10.16 0.49 2.92e-21 Huntington's disease progression; CRC cis rs7707921 0.723 rs226197 chr5:81574925 G/A cg21483461 chr5:81570383 RPS23 0.36 5.61 0.3 4.31e-8 Breast cancer; CRC cis rs514406 0.644 rs7530078 chr1:53204861 G/T cg24675658 chr1:53192096 ZYG11B 0.72 11.92 0.55 1.85e-27 Monocyte count; CRC cis rs4604732 0.631 rs10754561 chr1:247622800 A/G cg12758973 chr1:247694275 LOC148824;OR2C3 0.37 5.85 0.31 1.16e-8 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CRC cis rs4713118 0.615 rs9295747 chr6:27736993 G/T cg08798685 chr6:27730294 NA 0.4 5.94 0.31 7.35e-9 Parkinson's disease; CRC cis rs1046896 0.520 rs9895409 chr17:80902719 C/T cg19500275 chr17:80737654 TBCD 0.47 6.54 0.34 2.35e-10 Glycated hemoglobin levels; CRC cis rs1348850 0.567 rs12994392 chr2:178536640 A/G cg22681709 chr2:178499509 PDE11A -0.44 -8.16 -0.41 7.37e-15 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC trans rs8141529 0.507 rs5762936 chr22:29381377 A/G cg10064897 chr1:46598380 PIK3R3 0.61 6.8 0.35 4.96e-11 Lymphocyte counts; CRC cis rs7209700 0.632 rs11657963 chr17:45347533 G/A cg17185639 chr17:45330862 ITGB3 0.37 6.0 0.31 5.11e-9 IgG glycosylation; CRC cis rs72772090 0.539 rs3335 chr5:96115070 T/G cg17330273 chr5:96107758 CAST;ERAP1 -0.7 -6.45 -0.34 3.94e-10 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs1953600 0.870 rs2788295 chr10:81941007 C/G cg00277334 chr10:82204260 NA 0.36 5.89 0.31 9.54e-9 Sarcoidosis; CRC cis rs6504622 0.875 rs11652318 chr17:45041094 T/C cg16759221 chr17:45003025 GOSR2 -0.55 -8.68 -0.43 1.85e-16 Orofacial clefts; CRC cis rs7264396 0.563 rs73902913 chr20:34432784 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.47 -6.65 -0.34 1.19e-10 Total cholesterol levels; CRC cis rs9894429 0.646 rs7405870 chr17:79617284 G/A cg21984481 chr17:79567631 NPLOC4 -0.44 -7.49 -0.38 6.58e-13 Eye color traits; CRC trans rs9825823 0.617 rs2083264 chr3:61074229 A/G cg06805572 chr2:10444432 HPCAL1 0.45 6.24 0.33 1.37e-9 Depressive symptom measurement or major depressive disorder; CRC trans rs10435719 0.780 rs9692662 chr8:11789863 C/T cg06636001 chr8:8085503 FLJ10661 0.48 7.19 0.37 4.52e-12 C-reactive protein levels or triglyceride levels (pleiotropy); CRC cis rs6952808 0.717 rs6967442 chr7:1926090 A/G cg14004847 chr7:1930337 MAD1L1 -0.5 -7.62 -0.39 2.76e-13 Bipolar disorder and schizophrenia; CRC cis rs73206853 0.764 rs56128816 chr12:110775609 T/C cg12870014 chr12:110450643 ANKRD13A 0.84 10.14 0.49 3.42e-21 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC cis rs1150668 0.796 rs1005125 chr6:28367355 G/A cg12273811 chr6:28175739 NA 0.39 5.77 0.3 1.79e-8 Pubertal anthropometrics; CRC cis rs2204008 0.805 rs11514348 chr12:38243427 T/C cg26384229 chr12:38710491 ALG10B 0.69 9.22 0.45 3.69e-18 Bladder cancer; CRC cis rs10504229 0.728 rs59266065 chr8:58156236 A/G cg21724239 chr8:58056113 NA 0.64 8.46 0.42 8.61e-16 Developmental language disorder (linguistic errors); CRC cis rs11098499 0.954 rs13145352 chr4:120409963 C/T cg09307838 chr4:120376055 NA -0.65 -9.83 -0.48 3.61e-20 Corneal astigmatism; CRC cis rs2836974 0.932 rs13048178 chr21:40561012 G/T cg06238570 chr21:40685208 BRWD1 0.79 10.85 0.51 1.23e-23 Cognitive function; CRC cis rs6694672 0.850 rs10754213 chr1:197055925 T/C cg13682187 chr1:196946512 CFHR5 0.48 7.65 0.39 2.3e-13 Asthma; CRC cis rs7618915 0.501 rs3733045 chr3:52643307 A/G cg10802521 chr3:52805072 NEK4 -0.56 -8.74 -0.43 1.22e-16 Bipolar disorder; CRC trans rs561341 0.941 rs72825736 chr17:30330286 G/A cg27661571 chr11:113659931 NA -0.94 -10.92 -0.52 7.04e-24 Hip circumference adjusted for BMI; CRC cis rs514406 0.698 rs576891 chr1:53364976 A/G cg25767906 chr1:53392781 SCP2 -0.5 -7.62 -0.39 2.72e-13 Monocyte count; CRC cis rs7726839 0.540 rs7434 chr5:660804 A/G cg14541582 chr5:601475 NA 0.32 6.52 0.34 2.67e-10 Obesity-related traits; CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg21815882 chr7:26241064 CBX3;HNRNPA2B1 -0.54 -6.49 -0.34 3.22e-10 Diisocyanate-induced asthma; CRC cis rs7618915 0.501 rs13079063 chr3:52744460 A/G cg05573699 chr3:52720067 GNL3;PBRM1 -0.48 -6.96 -0.36 1.87e-11 Bipolar disorder; CRC cis rs10911390 0.793 rs7552232 chr1:183582287 T/A cg11505048 chr1:183622726 RGL1;APOBEC4 0.69 5.76 0.3 1.95e-8 Systemic lupus erythematosus; CRC cis rs9925964 0.933 rs56314408 chr16:31117389 T/C cg03418659 chr16:31128414 MYST1 -0.49 -7.23 -0.37 3.35e-12 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs12586317 0.553 rs3809448 chr14:35515096 C/T cg16230307 chr14:35515116 FAM177A1 0.92 10.75 0.51 2.64e-23 Psoriasis; CRC trans rs11098499 0.780 rs7692994 chr4:120427489 C/A cg25214090 chr10:38739885 LOC399744 0.62 9.87 0.48 2.71e-20 Corneal astigmatism; CRC trans rs2303319 0.582 rs56315911 chr2:162560186 G/T cg03757145 chr4:76555832 CDKL2 -0.65 -6.02 -0.31 4.58e-9 Cognitive function; CRC cis rs938554 0.571 rs4144 chr4:10016322 T/C cg00071950 chr4:10020882 SLC2A9 0.54 7.96 0.4 2.77e-14 Blood metabolite levels; CRC cis rs2882667 0.931 rs10077896 chr5:138356756 G/A cg09476006 chr5:138032270 NA 0.44 7.21 0.37 3.87e-12 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs747650 0.504 rs11602250 chr11:46965730 G/A cg19486271 chr11:47235900 DDB2 0.43 5.89 0.31 9.44e-9 Acne (severe); CRC cis rs769267 0.965 rs2269873 chr19:19392401 T/C cg03709012 chr19:19516395 GATAD2A 0.72 10.98 0.52 4.29e-24 Tonsillectomy; CRC cis rs7258465 1.000 rs2007981 chr19:18567555 C/A cg06462663 chr19:18546047 ISYNA1 0.47 7.01 0.36 1.35e-11 Breast cancer; CRC cis rs780096 0.526 rs780107 chr2:27684734 A/G cg17158414 chr2:27665306 KRTCAP3 -0.3 -6.68 -0.35 9.98e-11 Total body bone mineral density; CRC cis rs2421770 0.530 rs6484784 chr11:35368347 A/C cg13971030 chr11:35366721 SLC1A2 0.38 6.55 0.34 2.27e-10 Staphylococcus aureus nasal carriage (persistent); CRC cis rs6500602 0.627 rs11639998 chr16:4527109 T/C cg08645402 chr16:4508243 NA 0.57 8.31 0.42 2.58e-15 Schizophrenia; CRC cis rs2658782 0.526 rs3020062 chr11:93061159 T/C cg15737290 chr11:93063684 CCDC67 0.67 10.64 0.51 6.43e-23 Pulmonary function decline; CRC cis rs4604732 0.536 rs4925674 chr1:247636906 C/T cg02104434 chr1:247694406 LOC148824;OR2C3 0.49 7.5 0.38 5.8e-13 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CRC cis rs4938330 0.512 rs4938327 chr11:116906728 T/C cg01368799 chr11:117014884 PAFAH1B2 -0.43 -5.97 -0.31 6.14e-9 Blood protein levels; CRC cis rs3820068 0.705 rs59502343 chr1:15872617 T/C cg27534772 chr1:16042836 PLEKHM2 0.42 6.97 0.36 1.78e-11 Systolic blood pressure; CRC cis rs877282 0.583 rs11595057 chr10:819203 A/C cg17470449 chr10:769945 NA 0.41 6.03 0.32 4.5e-9 Uric acid levels; CRC cis rs1451375 0.785 rs6593010 chr7:50629888 A/G cg14593290 chr7:50529359 DDC 0.58 8.0 0.4 2.13e-14 Malaria; CRC cis rs739401 0.611 rs12284275 chr11:3024384 T/C cg08508325 chr11:3079039 CARS -0.5 -9.15 -0.45 6.25e-18 Longevity; CRC cis rs7586879 0.789 rs7560156 chr2:25124794 T/C cg04586622 chr2:25135609 ADCY3 -0.57 -9.51 -0.46 4.22e-19 Body mass index; CRC cis rs6879260 1.000 rs6879260 chr5:179731014 A/G cg13944838 chr5:179740914 GFPT2 -0.69 -11.35 -0.53 2.06e-25 Height; CRC cis rs5769765 0.819 rs9616377 chr22:50310880 T/C cg02269571 chr22:50332266 NA -0.6 -7.82 -0.4 7.04e-14 Schizophrenia; CRC cis rs1552244 0.882 rs13088350 chr3:10044626 T/C cg08888203 chr3:10149979 C3orf24 0.62 8.3 0.42 2.65e-15 Alzheimer's disease; CRC cis rs4664308 1.000 rs4665147 chr2:160917062 A/G cg03641300 chr2:160917029 PLA2R1 -0.75 -12.13 -0.56 3.12e-28 Idiopathic membranous nephropathy; CRC cis rs1448094 0.512 rs61930137 chr12:86242930 C/T cg25456477 chr12:86230367 RASSF9 0.32 5.67 0.3 3.13e-8 Major depressive disorder; CRC cis rs9487051 0.799 rs351725 chr6:109547939 G/A cg21918786 chr6:109611834 NA -0.35 -5.99 -0.31 5.62e-9 Reticulocyte fraction of red cells; CRC cis rs7408868 0.520 rs1043994 chr19:15302844 T/C cg14696996 chr19:15285081 NOTCH3 0.71 7.39 0.38 1.26e-12 Pulse pressure; CRC trans rs11098499 0.739 rs10031033 chr4:120151452 C/T cg25214090 chr10:38739885 LOC399744 0.41 6.44 0.33 4.34e-10 Corneal astigmatism; CRC cis rs7666738 0.830 rs2865981 chr4:99031493 G/A cg17366294 chr4:99064904 C4orf37 0.44 7.47 0.38 7.24e-13 Colonoscopy-negative controls vs population controls; CRC cis rs7772486 0.754 rs4896839 chr6:146019689 T/G cg05347473 chr6:146136440 FBXO30 -0.39 -5.86 -0.31 1.12e-8 Lobe attachment (rater-scored or self-reported); CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg06648271 chr10:126432949 FAM53B 0.47 6.33 0.33 8.16e-10 Anxiety disorder; CRC trans rs11764590 0.694 rs10241537 chr7:2083358 A/G cg11693508 chr17:37793320 STARD3 0.46 6.22 0.32 1.5e-9 Neuroticism; CRC cis rs2243480 1.000 rs13235972 chr7:65883605 C/T cg18252515 chr7:66147081 NA -1.3 -15.32 -0.65 2.37e-40 Diabetic kidney disease; CRC cis rs10992471 0.603 rs2094281 chr9:95290654 C/G cg14631576 chr9:95140430 CENPP 0.4 7.11 0.36 7.48e-12 Visceral adipose tissue/subcutaneous adipose tissue ratio; CRC trans rs1728785 0.591 rs10775305 chr16:68656460 A/G cg04657470 chr2:198365150 HSPE1;HSPD1 0.61 7.49 0.38 6.29e-13 Ulcerative colitis; CRC cis rs7267979 0.844 rs35735333 chr20:25337205 T/G cg24626310 chr20:25276739 ABHD12;PYGB -0.34 -5.66 -0.3 3.28e-8 Liver enzyme levels (alkaline phosphatase); CRC cis rs2463822 0.583 rs72919477 chr11:62042403 G/C cg06239285 chr11:62104954 ASRGL1 -0.82 -8.26 -0.41 3.54e-15 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs4925114 0.568 rs4925109 chr17:17661802 A/G cg04398451 chr17:18023971 MYO15A 0.42 7.11 0.36 7.29e-12 Body mass index; CRC cis rs921968 0.565 rs755112 chr2:219606052 C/T cg02176678 chr2:219576539 TTLL4 -0.39 -6.19 -0.32 1.76e-9 Mean corpuscular hemoglobin concentration; CRC trans rs2303319 0.504 rs62187570 chr2:162373899 C/G cg09481857 chr22:21368659 P2RX6;MGC16703 -0.64 -6.11 -0.32 2.75e-9 Cognitive function; CRC cis rs6570726 0.935 rs419854 chr6:145844085 A/C cg05347473 chr6:146136440 FBXO30 0.38 6.13 0.32 2.58e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs9814567 0.752 rs4955547 chr3:134334975 A/G cg06109529 chr3:134205091 CEP63;ANAPC13 -0.68 -9.74 -0.47 7.1e-20 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs1448094 0.791 rs10863110 chr12:86328523 T/C cg02569458 chr12:86230093 RASSF9 0.46 7.68 0.39 1.89e-13 Major depressive disorder; CRC cis rs7107174 1.000 rs11237456 chr11:78040780 C/G cg02023728 chr11:77925099 USP35 0.49 8.69 0.43 1.68e-16 Testicular germ cell tumor; CRC cis rs3026101 0.671 rs739766 chr17:5290599 G/A cg25236894 chr17:5323110 RPAIN;NUP88 0.42 6.82 0.35 4.25e-11 Body mass index; CRC trans rs4478147 0.636 rs4529013 chr4:87463813 G/A cg01215037 chr19:50083917 PRRG2;NOSIP 0.45 5.97 0.31 6.1e-9 Migraine - clinic-based; CRC cis rs372883 0.624 rs1153286 chr21:30684383 A/G cg08807101 chr21:30365312 RNF160 -0.48 -6.9 -0.36 2.69e-11 Pancreatic cancer; CRC cis rs57590327 0.503 rs13080520 chr3:81850742 T/C cg07356753 chr3:81810745 GBE1 -0.46 -6.24 -0.33 1.35e-9 Extraversion; CRC cis rs8141529 0.732 rs3788409 chr22:29198151 T/G cg15103426 chr22:29168792 CCDC117 0.59 8.61 0.43 3e-16 Lymphocyte counts; CRC cis rs4243830 0.850 rs4908910 chr1:6599362 T/A cg22792644 chr1:6614718 TAS1R1;NOL9 -0.69 -7.76 -0.39 1.08e-13 Body mass index; CRC cis rs2842992 0.662 rs2273825 chr6:160211424 A/C cg11366901 chr6:160182831 ACAT2 0.73 10.92 0.52 6.54e-24 Age-related macular degeneration (geographic atrophy); CRC cis rs7726839 0.561 rs72703050 chr5:582917 A/C cg09021430 chr5:549028 NA -0.86 -10.88 -0.51 9.64e-24 Obesity-related traits; CRC cis rs6951245 0.678 rs28600085 chr7:1169636 C/T cg20603222 chr7:1096387 C7orf50;GPR146 -0.63 -7.88 -0.4 4.72e-14 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs1799949 0.602 rs4600503 chr17:41414324 C/G cg19454999 chr17:41278357 BRCA1;NBR2 0.52 8.15 0.41 7.64e-15 Menopause (age at onset); CRC cis rs891088 0.622 rs10426094 chr19:7205240 C/T cg00428638 chr19:7224713 INSR -0.58 -7.32 -0.37 1.97e-12 Hip circumference adjusted for BMI;Height; CRC cis rs459193 1.000 rs157843 chr5:55799184 G/T cg26646659 chr5:55776364 NA 0.47 6.38 0.33 5.95e-10 Coronary artery disease;Type 2 diabetes;Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);Waist-to-hip ratio adjusted for BMI in non-smokers;Waist-to-hip ratio adjusted for BMI (smoking interaction);Waist-to-hip ratio adjusted for body mass index;Waist-hip ratio;Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction); CRC cis rs490234 0.934 rs10119068 chr9:128424508 A/G cg14078157 chr9:128172775 NA -0.37 -6.22 -0.32 1.49e-9 Mean arterial pressure; CRC cis rs9522267 0.737 rs9522289 chr13:112232110 G/A cg10483660 chr13:112241077 NA -0.4 -7.07 -0.36 9.13e-12 Hepatitis; CRC cis rs4713118 0.662 rs9468276 chr6:28027688 A/C cg21251018 chr6:28226885 NKAPL 0.46 6.53 0.34 2.56e-10 Parkinson's disease; CRC cis rs1552244 0.816 rs17050701 chr3:10041554 A/G cg08888203 chr3:10149979 C3orf24 0.62 8.3 0.42 2.65e-15 Alzheimer's disease; CRC cis rs6570726 0.935 rs400968 chr6:145819718 A/G cg05347473 chr6:146136440 FBXO30 0.38 5.94 0.31 7.32e-9 Lobe attachment (rater-scored or self-reported); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg11192808 chr8:101170185 SPAG1 0.46 7.57 0.39 3.77e-13 Liver disease severity in Alagille syndrome; CRC cis rs9911578 1.000 rs9897326 chr17:56902297 A/G cg05425664 chr17:57184151 TRIM37 -0.49 -7.72 -0.39 1.45e-13 Intelligence (multi-trait analysis); CRC cis rs10089 1.000 rs4835945 chr5:127526481 C/A cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.69 9.46 0.46 6.07e-19 Ileal carcinoids; CRC cis rs7511006 0.893 rs5771104 chr22:50651839 C/T cg16473166 chr22:50639996 SELO 0.56 8.69 0.43 1.78e-16 Obesity-related traits; CRC cis rs11214589 0.806 rs4551806 chr11:113250540 T/A cg14159747 chr11:113255604 NA 0.6 12.17 0.56 2.18e-28 Neuroticism; CRC cis rs9611565 0.659 rs12483998 chr22:41935362 A/G cg17554472 chr22:41940697 POLR3H -0.56 -5.83 -0.31 1.34e-8 Vitiligo; CRC cis rs9398803 0.805 rs1591805 chr6:126717064 A/G cg19875578 chr6:126661172 C6orf173 0.4 5.63 0.3 3.86e-8 Male-pattern baldness; CRC cis rs9858542 0.543 rs2230929 chr3:49343175 G/A cg00383909 chr3:49044727 WDR6 0.68 7.02 0.36 1.26e-11 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs13191362 0.935 rs34603926 chr6:163266793 A/T cg06582575 chr6:163149167 PACRG;PARK2 0.67 8.46 0.42 8.86e-16 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs972578 1.000 rs4822248 chr22:43403379 G/A cg01576275 chr22:43409880 NA -0.51 -8.38 -0.42 1.53e-15 Mean platelet volume; CRC cis rs28386778 0.897 rs2727287 chr17:61904728 G/A cg22520471 chr17:61851767 DDX42;CCDC47 0.75 11.88 0.55 2.55e-27 Prudent dietary pattern; CRC cis rs11098499 0.909 rs28571712 chr4:120375980 G/A cg09307838 chr4:120376055 NA 0.72 11.07 0.52 2.07e-24 Corneal astigmatism; CRC cis rs2882667 0.898 rs6882583 chr5:138385796 C/T cg04439458 chr5:138467593 SIL1 -0.33 -5.99 -0.31 5.39e-9 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs478304 0.619 rs10791822 chr11:65428706 T/C cg05805236 chr11:65401703 PCNXL3 -0.37 -5.75 -0.3 2.08e-8 Acne (severe); CRC cis rs6938 0.534 rs4886636 chr15:75196176 G/A cg05627522 chr15:75251581 NA 0.38 5.82 0.31 1.36e-8 Breast cancer; CRC cis rs1862618 0.853 rs252902 chr5:56116085 A/G cg18230493 chr5:56204884 C5orf35 -0.7 -9.26 -0.45 2.62e-18 Initial pursuit acceleration; CRC cis rs929596 0.561 rs7564935 chr2:234645186 G/T cg02227331 chr2:234663937 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 0.42 6.17 0.32 2.05e-9 Total bilirubin levels in HIV-1 infection; CRC cis rs6684514 0.922 rs2075166 chr1:156215562 G/A cg16558208 chr1:156270281 VHLL 0.62 9.42 0.46 8.08e-19 Mean corpuscular hemoglobin concentration;Glycated hemoglobin levels; CRC cis rs7927771 1.000 rs4752857 chr11:47655752 C/T cg20307385 chr11:47447363 PSMC3 -0.56 -7.87 -0.4 5.07e-14 Subjective well-being; CRC trans rs7267979 0.899 rs6115213 chr20:25550372 G/A cg17903999 chr18:56338584 MALT1 -0.43 -6.98 -0.36 1.61e-11 Liver enzyme levels (alkaline phosphatase); CRC cis rs6912958 0.781 rs9444522 chr6:88309705 G/A cg08069147 chr6:88032118 GJB7;C6orf162 -0.57 -8.59 -0.43 3.63e-16 Monocyte percentage of white cells; CRC cis rs6951245 0.744 rs10265736 chr7:1172465 C/T cg04025307 chr7:1156635 C7orf50 0.67 7.69 0.39 1.67e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs9926296 0.529 rs7195906 chr16:89806347 A/T cg03388025 chr16:89894329 SPIRE2 0.42 8.37 0.42 1.73e-15 Vitiligo; CRC cis rs2011503 0.883 rs17216041 chr19:19366643 C/T cg02887458 chr19:19495540 GATAD2A -0.43 -5.78 -0.3 1.73e-8 Bipolar disorder; CRC trans rs7826238 0.564 rs2921053 chr8:8319963 G/C cg16141378 chr3:129829833 LOC729375 -0.5 -7.55 -0.38 4.22e-13 Systolic blood pressure; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg14213517 chr2:102972205 NA 0.41 6.95 0.36 1.93e-11 Liver disease severity in Alagille syndrome; CRC cis rs7762018 1.000 rs6923339 chr6:170128033 T/A cg17545662 chr6:170176663 C6orf70 0.56 6.45 0.34 3.94e-10 Thiazide-induced adverse metabolic effects in hypertensive patients; CRC trans rs7395662 0.591 rs12807777 chr11:48593754 A/T cg00717180 chr2:96193071 NA -0.37 -6.11 -0.32 2.77e-9 HDL cholesterol; CRC cis rs9467711 0.591 rs13203673 chr6:25979122 T/C cg12315302 chr6:26189340 HIST1H4D 0.79 6.29 0.33 1.04e-9 Autism spectrum disorder or schizophrenia; CRC cis rs873946 0.564 rs2803991 chr10:134557068 A/G cg26818010 chr10:134567672 INPP5A -0.59 -8.21 -0.41 5.11e-15 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CRC cis rs1707322 1.000 rs12133129 chr1:46373348 C/T cg03146154 chr1:46216737 IPP 0.51 7.16 0.37 5.32e-12 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs8032158 1.000 rs2288344 chr15:56122347 T/G cg02198044 chr15:56286336 NEDD4 -0.39 -6.03 -0.32 4.32e-9 Keloid; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg04543156 chr10:89577850 ATAD1;CFLP1 0.47 6.58 0.34 1.83e-10 Response to antipsychotic treatment; CRC cis rs1943345 0.556 rs606381 chr11:82907249 G/A cg07047830 chr11:82868014 PCF11 0.47 6.64 0.34 1.32e-10 Obesity-related traits; CRC cis rs617791 0.530 rs10791835 chr11:65750924 C/A cg27068330 chr11:65405492 SIPA1 -0.47 -6.47 -0.34 3.57e-10 Breast cancer; CRC cis rs727505 0.908 rs56155943 chr7:124606346 T/G cg23710748 chr7:124431027 NA -0.82 -14.01 -0.61 2.7e-35 Lewy body disease; CRC cis rs1267303 0.642 rs61783087 chr1:46999955 T/C cg25110126 chr1:46999211 NA 0.61 8.77 0.44 1e-16 Monobrow; CRC cis rs8060686 0.920 rs2292316 chr16:67861134 C/G cg19582491 chr16:67682965 RLTPR 0.61 7.45 0.38 8.51e-13 HDL cholesterol;Metabolic syndrome; CRC cis rs4819052 0.788 rs13049700 chr21:46701909 G/C cg19498844 chr21:46707878 POFUT2;LOC642852 0.76 10.91 0.52 7.51e-24 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC trans rs8002861 0.626 rs9533634 chr13:44397815 T/C cg12856521 chr11:46389249 DGKZ -0.51 -8.57 -0.43 4.13e-16 Leprosy; CRC cis rs1801251 1.000 rs35085837 chr2:233624363 A/G cg25237894 chr2:233734115 C2orf82 0.54 8.8 0.44 7.77e-17 Coronary artery disease; CRC cis rs10870270 0.956 rs67378218 chr10:133752420 A/C cg17892150 chr10:133769511 PPP2R2D -0.75 -11.44 -0.53 9.82e-26 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; CRC cis rs2645694 0.626 rs2645705 chr4:77830434 G/A cg18351406 chr4:77819688 ANKRD56 0.51 7.6 0.39 3.1400000000000003e-13 Emphysema distribution in smoking; CRC cis rs863345 0.604 rs7512592 chr1:158489945 G/A cg12129480 chr1:158549410 OR10X1 -0.3 -6.25 -0.33 1.25e-9 Pneumococcal bacteremia; CRC cis rs12711979 0.509 rs10187740 chr2:3823965 A/G cg17052675 chr2:3827356 NA 0.86 20.19 0.74 1.53e-59 Itch intensity from mosquito bite adjusted by bite size; CRC cis rs9400271 0.632 rs6899616 chr6:109584885 A/G cg01475377 chr6:109611718 NA -0.35 -6.09 -0.32 3.19e-9 Sum neutrophil eosinophil counts;Sum basophil neutrophil counts;White blood cell count;Neutrophil count;Myeloid white cell count;Granulocyte count; CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg14022721 chr22:25507536 KIAA1671 -0.49 -6.23 -0.32 1.45e-9 Diisocyanate-induced asthma; CRC cis rs2115630 1.000 rs6496452 chr15:85372645 A/T cg09876464 chr15:85330779 ZNF592 0.46 7.96 0.4 2.81e-14 P wave terminal force; CRC cis rs4819052 0.788 rs2236449 chr21:46702506 C/T cg02159808 chr21:46707872 POFUT2;LOC642852 0.58 7.61 0.39 3e-13 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs9783347 1.000 rs2061164 chr11:18329006 T/C cg15585147 chr11:18324498 HPS5 0.42 5.9 0.31 8.87e-9 Pancreatic cancer; CRC trans rs9858542 0.953 rs1801143 chr3:49570200 C/T cg21659725 chr3:3221576 CRBN -0.67 -9.2 -0.45 4.1e-18 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs7914558 0.966 rs7085598 chr10:104650128 T/C cg04362960 chr10:104952993 NT5C2 0.59 8.93 0.44 3.13e-17 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs9611565 0.527 rs73178638 chr22:41942904 T/C cg17554472 chr22:41940697 POLR3H -0.58 -6.11 -0.32 2.87e-9 Vitiligo; CRC cis rs7666738 0.830 rs28417716 chr4:98864859 C/T cg05340658 chr4:99064831 C4orf37 0.56 8.33 0.42 2.21e-15 Colonoscopy-negative controls vs population controls; CRC cis rs365302 1.000 rs480052 chr6:159651869 C/T cg14500486 chr6:159655392 FNDC1 0.44 6.82 0.35 4.31e-11 Coronary heart disease; CRC cis rs1215050 0.765 rs644839 chr4:98716357 C/A cg05340658 chr4:99064831 C4orf37 0.47 6.86 0.35 3.43e-11 Waist-to-hip ratio adjusted for body mass index; CRC cis rs7274811 0.744 rs2071056 chr20:32265513 A/G cg03904042 chr20:32255491 NECAB3;C20orf134 -0.48 -6.77 -0.35 6.05e-11 Height; CRC cis rs1003719 0.788 rs9975168 chr21:38450557 A/G cg10648535 chr21:38446584 PIGP;TTC3 -0.53 -7.52 -0.38 5.21e-13 Eye color traits; CRC cis rs1403694 0.966 rs1648715 chr3:186439618 A/G cg04611788 chr3:186434169 KNG1 -0.46 -7.13 -0.37 6.6e-12 Blood protein levels; CRC cis rs8141529 0.711 rs5752797 chr22:29179998 C/T cg02153584 chr22:29168773 CCDC117 0.48 6.14 0.32 2.33e-9 Lymphocyte counts; CRC cis rs9322193 0.683 rs113281309 chr6:150108425 T/G cg00933542 chr6:150070202 PCMT1 0.28 5.63 0.3 3.86e-8 Lung cancer; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg12066438 chr12:98909292 TMPO;LOC100128191 0.45 6.17 0.32 2.01e-9 Anxiety disorder; CRC cis rs12791968 0.765 rs12790121 chr11:45001089 G/A cg11846598 chr11:44996168 LOC221122 -0.58 -8.49 -0.42 7.02e-16 Inhibitory control; CRC trans rs951252 0.504 rs11734405 chr4:146081096 C/T cg24866706 chr3:96338474 NA 0.51 6.72 0.35 7.9e-11 Hip circumference; CRC cis rs501120 0.925 rs684521 chr10:44752523 G/A cg09554077 chr10:44749378 NA 0.89 13.1 0.59 7.51e-32 Coronary artery disease;Coronary heart disease; CRC cis rs7223966 1.000 rs9912904 chr17:61763534 A/C cg05941027 chr17:61774174 LIMD2 0.37 6.71 0.35 8.59e-11 Hip circumference adjusted for BMI;Body mass index; CRC cis rs67340775 0.541 rs200973 chr6:27858421 A/G cg08798685 chr6:27730294 NA -0.57 -6.48 -0.34 3.25e-10 Lung cancer in ever smokers; CRC cis rs1552244 1.000 rs6772315 chr3:10113644 G/A cg08888203 chr3:10149979 C3orf24 0.72 9.91 0.48 1.93e-20 Alzheimer's disease; CRC cis rs7591163 1.000 rs4487084 chr2:228713179 G/A cg08034379 chr2:228736324 WDR69 -0.53 -7.22 -0.37 3.59e-12 Blood pressure; CRC cis rs2153535 0.580 rs9379215 chr6:8481225 G/A cg07606381 chr6:8435919 SLC35B3 0.67 10.78 0.51 2.07e-23 Motion sickness; CRC cis rs8060686 0.641 rs12598274 chr16:68084099 G/A cg08314208 chr16:67682810 RLTPR -0.57 -6.09 -0.32 3.17e-9 HDL cholesterol;Metabolic syndrome; CRC cis rs4285028 0.747 rs4048699 chr3:121404483 A/G cg20356878 chr3:121714668 ILDR1 0.42 5.81 0.3 1.5e-8 Multiple sclerosis; CRC cis rs9491140 0.539 rs2208814 chr6:124692555 G/A cg05308643 chr6:124982296 NKAIN2 0.52 6.88 0.35 3.1e-11 Neuroticism; CRC cis rs6840360 0.667 rs4266275 chr4:152348064 A/G cg09659197 chr4:152720779 NA 0.34 6.67 0.35 1.06e-10 Intelligence (multi-trait analysis); CRC cis rs10504229 0.636 rs117439064 chr8:58055279 A/G cg22535103 chr8:58192502 C8orf71 -0.75 -8.32 -0.42 2.37e-15 Developmental language disorder (linguistic errors); CRC cis rs9837602 0.872 rs1489816 chr3:99769088 C/G cg07805332 chr3:99536008 MIR548G;C3orf26 0.46 6.04 0.32 4.06e-9 Breast cancer; CRC cis rs950169 0.922 rs12910334 chr15:84958318 G/A cg17507749 chr15:85114479 UBE2QP1 0.74 10.55 0.5 1.33e-22 Schizophrenia; CRC cis rs7833790 1.000 rs1463259 chr8:82737745 A/G cg17211192 chr8:82754475 SNX16 -0.54 -6.6 -0.34 1.62e-10 Diastolic blood pressure; CRC cis rs4243830 1.000 rs12401795 chr1:6594773 A/G cg22792644 chr1:6614718 TAS1R1;NOL9 0.79 7.64 0.39 2.41e-13 Body mass index; CRC cis rs7666738 0.830 rs7659420 chr4:98878714 G/C cg05340658 chr4:99064831 C4orf37 0.59 8.98 0.44 2.15e-17 Colonoscopy-negative controls vs population controls; CRC cis rs1538970 0.962 rs9429158 chr1:45821393 A/G cg05343316 chr1:45956843 TESK2 0.64 8.98 0.44 2.18e-17 Platelet count; CRC cis rs7605827 0.930 rs722328 chr2:15657164 T/C cg19274914 chr2:15703543 NA 0.39 5.89 0.31 9.8e-9 Educational attainment (years of education); CRC cis rs9611565 0.694 rs202628 chr22:41849513 A/G cg06481639 chr22:41940642 POLR3H -0.49 -6.16 -0.32 2.09e-9 Vitiligo; CRC trans rs6951245 0.872 rs77434655 chr7:1098405 G/A cg13565492 chr6:43139072 SRF -0.72 -7.44 -0.38 8.63e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs9494145 0.838 rs9483788 chr6:135435501 T/C cg22676075 chr6:135203613 NA 0.52 6.25 0.33 1.27e-9 Mean platelet volume;Platelet count;Fetal hemoglobin levels in sickle cell anemia;Red blood cell traits; CRC trans rs2228479 0.702 rs12600047 chr16:89831630 G/A cg24644049 chr4:85504048 CDS1 0.89 7.15 0.37 5.62e-12 Skin colour saturation; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg13348770 chr6:122720548 HSF2 0.47 6.97 0.36 1.75e-11 Intelligence (multi-trait analysis); CRC cis rs9914988 0.943 rs4795465 chr17:27151498 A/G cg16670446 chr17:27188758 MIR451;MIR144 -0.53 -8.35 -0.42 1.95e-15 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs2836974 0.568 rs419469 chr21:40537234 C/T cg17971929 chr21:40555470 PSMG1 0.72 11.34 0.53 2.15e-25 Cognitive function; CRC cis rs354033 1.000 rs354043 chr7:149297332 C/T cg24335155 chr7:149193227 ZNF746 0.38 6.12 0.32 2.7e-9 Multiple sclerosis; CRC cis rs727505 0.954 rs67146030 chr7:124561790 T/G cg23710748 chr7:124431027 NA -0.85 -14.97 -0.64 5.39e-39 Lewy body disease; CRC cis rs4423214 0.879 rs10898144 chr11:71151540 A/T cg13043300 chr11:71146211 DHCR7 -0.41 -5.82 -0.31 1.43e-8 Vitamin D levels; CRC cis rs1915146 0.546 rs1715862 chr10:126856255 C/T cg17191109 chr10:126851326 NA -0.44 -6.39 -0.33 5.65e-10 Menarche (age at onset); CRC cis rs4722166 0.630 rs7808457 chr7:22798265 A/T cg26061582 chr7:22766209 IL6 -0.55 -8.42 -0.42 1.15e-15 Lung cancer; CRC trans rs7517126 0.858 rs12726401 chr1:196660729 T/C cg00574530 chr5:134872064 NEUROG1 0.46 6.01 0.31 5.06e-9 Blood protein levels; CRC cis rs6700896 0.931 rs2154382 chr1:66131681 C/T cg04111102 chr1:66153794 NA 0.35 6.1 0.32 3.03e-9 C-reactive protein;Mean corpuscular volume;Mean corpuscular hemoglobin; CRC cis rs7647973 1.000 rs12583 chr3:49571462 G/T cg07636037 chr3:49044803 WDR6 -0.66 -7.84 -0.4 6.23e-14 Menarche (age at onset); CRC cis rs6860806 0.531 rs2631359 chr5:131707892 C/T cg18758796 chr5:131593413 PDLIM4 -0.4 -6.46 -0.34 3.7e-10 Breast cancer; CRC cis rs12983728 0.505 rs12460050 chr19:58666109 G/A cg08687515 chr19:58661962 ZNF329 0.48 6.04 0.32 4.19e-9 Cholesterol, total; CRC cis rs5750830 0.649 rs5757659 chr22:39812409 A/C cg25956985 chr22:39795188 MAP3K7IP1 -0.5 -6.73 -0.35 7.33e-11 Intelligence (multi-trait analysis); CRC cis rs6951245 1.000 rs77305932 chr7:1100861 T/A cg03188948 chr7:1209495 NA 0.65 6.84 0.35 3.8e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs875971 0.540 rs35510581 chr7:65578777 G/A cg00343986 chr7:65444356 GUSB -0.49 -7.22 -0.37 3.53e-12 Aortic root size; CRC cis rs977987 0.750 rs4888407 chr16:75432390 T/C cg03315344 chr16:75512273 CHST6 0.51 8.61 0.43 3.09e-16 Dupuytren's disease; CRC cis rs10540 1.000 rs61876341 chr11:495892 C/G cg15790184 chr11:494944 RNH1 0.6 6.18 0.32 1.85e-9 Body mass index; CRC cis rs7259376 0.623 rs3926992 chr19:22505876 A/G cg02657401 chr19:22469223 NA -0.31 -6.6 -0.34 1.69e-10 Menopause (age at onset); CRC cis rs2836950 0.520 rs2836966 chr21:40637521 A/G cg17971929 chr21:40555470 PSMG1 -0.57 -8.19 -0.41 5.81e-15 Menarche (age at onset); CRC cis rs2404602 0.716 rs67920045 chr15:76800084 G/A cg22467129 chr15:76604101 ETFA -0.39 -6.37 -0.33 6.39e-10 Blood metabolite levels; CRC cis rs919433 1.000 rs7422899 chr2:198163527 G/C cg20885578 chr2:198174922 NA -0.43 -6.83 -0.35 4.07e-11 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC cis rs9462027 0.628 rs9462030 chr6:34831280 C/T cg07306190 chr6:34760872 UHRF1BP1 -0.35 -6.13 -0.32 2.48e-9 Systemic lupus erythematosus; CRC cis rs7584330 0.518 rs74003105 chr2:238446851 T/C cg08992911 chr2:238395768 MLPH 0.61 6.25 0.33 1.26e-9 Prostate cancer; CRC cis rs4713118 0.621 rs10484403 chr6:28033523 A/G cg03623178 chr6:28175578 NA 0.92 12.13 0.56 3.12e-28 Parkinson's disease; CRC cis rs3741151 1.000 rs57893472 chr11:73042826 C/T cg17517138 chr11:73019481 ARHGEF17 0.68 7.08 0.36 8.91e-12 GIP levels in response to oral glucose tolerance test (120 minutes); CRC cis rs10504229 0.683 rs34804288 chr8:58117570 C/A cg02725872 chr8:58115012 NA -0.64 -11.55 -0.54 3.85e-26 Developmental language disorder (linguistic errors); CRC trans rs1814175 0.645 rs7115592 chr11:50013243 A/G cg11707556 chr5:10655725 ANKRD33B -0.52 -10.25 -0.49 1.36e-21 Height; CRC cis rs2243480 1.000 rs316307 chr7:65570171 C/T cg18252515 chr7:66147081 NA -1.17 -13.58 -0.6 1.22e-33 Diabetic kidney disease; CRC cis rs7617480 0.648 rs4858800 chr3:48755820 A/G cg20833759 chr3:49053208 WDR6;DALRD3 0.59 9.19 0.45 4.72e-18 Subjective well-being (multi-trait analysis);Menarche (age at onset); CRC cis rs9488822 0.676 rs12196579 chr6:116351724 G/T cg15226275 chr6:116381976 FRK 0.31 8.97 0.44 2.3e-17 Cholesterol, total;LDL cholesterol; CRC cis rs1865760 0.566 rs9358904 chr6:26068566 C/T cg17691542 chr6:26056736 HIST1H1C 0.55 8.5 0.42 6.92e-16 Height; CRC cis rs10504229 0.683 rs67035623 chr8:58139963 G/T cg02290350 chr8:58132656 NA -0.58 -8.16 -0.41 7.29e-15 Developmental language disorder (linguistic errors); CRC cis rs875971 0.862 rs10263690 chr7:65766453 G/C cg00343986 chr7:65444356 GUSB -0.45 -6.27 -0.33 1.12e-9 Aortic root size; CRC cis rs10870270 0.956 rs4131689 chr10:133744328 A/C cg17892150 chr10:133769511 PPP2R2D 0.75 11.59 0.54 2.75e-26 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; CRC trans rs1455244 0.700 rs7229302 chr18:11508904 G/T cg17465063 chr10:111985564 MXI1 0.39 6.21 0.32 1.6e-9 Schizophrenia; CRC cis rs7223966 0.921 rs2854207 chr17:61947107 C/G cg23090583 chr17:61904693 PSMC5;FTSJ3 0.52 6.45 0.34 3.99e-10 Hip circumference adjusted for BMI;Body mass index; CRC cis rs78545713 0.649 rs79662647 chr6:26217845 G/A cg01420254 chr6:26195488 NA 0.73 6.02 0.32 4.54e-9 Iron status biomarkers (total iron binding capacity); CRC cis rs10512697 0.655 rs13162816 chr5:3497691 C/T cg19473799 chr5:3511975 NA -0.82 -6.32 -0.33 8.41e-10 Immune response to smallpox vaccine (IL-6); CRC cis rs6502050 0.731 rs76421195 chr17:80109326 T/C cg11859384 chr17:80120422 CCDC57 -0.37 -5.85 -0.31 1.16e-8 Life satisfaction; CRC cis rs2645694 0.626 rs2703118 chr4:77823672 A/G cg03477792 chr4:77819574 ANKRD56 0.46 6.68 0.35 1.02e-10 Emphysema distribution in smoking; CRC cis rs9487051 0.652 rs6568559 chr6:109592751 C/T cg21918786 chr6:109611834 NA -0.42 -7.46 -0.38 7.91e-13 Reticulocyte fraction of red cells; CRC cis rs4665809 0.590 rs7579504 chr2:26439995 T/C cg27170947 chr2:26402098 FAM59B -0.59 -7.71 -0.39 1.53e-13 Gut microbiome composition (summer); CRC cis rs2439831 0.850 rs28707214 chr15:44131623 G/C cg02155558 chr15:43621948 ADAL;LCMT2 0.69 7.46 0.38 7.65e-13 Lung cancer in ever smokers; CRC cis rs9325144 0.555 rs7977200 chr12:38713745 C/T cg26384229 chr12:38710491 ALG10B 0.56 8.32 0.42 2.45e-15 Morning vs. evening chronotype; CRC trans rs6550704 0.687 rs9865314 chr3:22634337 A/G cg01497487 chr22:38141814 TRIOBP -0.44 -6.59 -0.34 1.78e-10 Daytime sleep phenotypes; CRC cis rs9368481 0.569 rs10946868 chr6:26887930 A/G cg18867708 chr6:26865862 GUSBL1 0.43 6.15 0.32 2.2e-9 Autism spectrum disorder or schizophrenia; CRC cis rs7618501 0.521 rs34654589 chr3:49911449 C/G cg05623727 chr3:50126028 RBM5 0.62 10.5 0.5 1.96e-22 Intelligence (multi-trait analysis); CRC cis rs2576037 0.526 rs10853545 chr18:44475220 A/T cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.63 -10.05 -0.48 6.52e-21 Personality dimensions; CRC cis rs6545883 0.929 rs9679557 chr2:61709349 C/A cg15711740 chr2:61764176 XPO1 -0.44 -5.81 -0.3 1.5e-8 Tuberculosis; CRC cis rs28386778 0.897 rs894408 chr17:61896814 C/T cg06601766 chr17:61851465 DDX42;CCDC47 0.44 5.96 0.31 6.33e-9 Prudent dietary pattern; CRC cis rs853679 0.517 rs9380059 chr6:28132358 A/C cg02631126 chr6:28058918 ZSCAN12L1 0.29 5.91 0.31 8.38e-9 Depression; CRC cis rs6840360 0.642 rs1596290 chr4:152410540 G/T cg09659197 chr4:152720779 NA 0.33 6.54 0.34 2.29e-10 Intelligence (multi-trait analysis); CRC cis rs8180040 0.966 rs17476234 chr3:47326298 G/A cg10298567 chr3:47292165 KIF9 0.44 7.08 0.36 9.03e-12 Colorectal cancer; CRC cis rs1799949 1.000 rs2037075 chr17:41305826 G/T cg01879757 chr17:41196368 BRCA1 -0.42 -6.42 -0.33 4.89e-10 Menopause (age at onset); CRC trans rs1864729 1.000 rs2053480 chr8:98278951 A/T cg08679828 chr8:102218111 ZNF706 0.56 7.02 0.36 1.28e-11 Estradiol plasma levels (breast cancer); CRC cis rs769267 0.930 rs2301786 chr19:19413947 A/G cg02546618 chr19:19431379 KIAA0892;SF4 0.46 6.3 0.33 9.47e-10 Tonsillectomy; CRC cis rs2276314 0.793 rs77590522 chr18:33629410 C/G cg05985134 chr18:33552581 C18orf21 0.5 6.42 0.33 4.75e-10 Endometriosis;Drug-induced torsades de pointes; CRC cis rs853679 0.506 rs1150693 chr6:28174590 T/C cg15786705 chr6:28176104 NA 0.78 10.83 0.51 1.38e-23 Depression; CRC cis rs10189230 0.935 rs6731133 chr2:222359155 C/T cg14652038 chr2:222343519 EPHA4 0.54 10.33 0.49 7.42e-22 Urate levels in lean individuals; CRC cis rs853679 0.567 rs9969098 chr6:28398748 G/T cg21251018 chr6:28226885 NKAPL 0.42 6.11 0.32 2.78e-9 Depression; CRC cis rs561341 0.883 rs1034626 chr17:30219500 C/G cg23018236 chr17:30244563 NA 0.51 6.78 0.35 5.7e-11 Hip circumference adjusted for BMI; CRC cis rs12594515 0.967 rs11070466 chr15:45984955 C/T cg06207120 chr15:45996521 NA 0.32 7.72 0.39 1.38e-13 Waist circumference;Weight; CRC cis rs17376456 0.825 rs74825443 chr5:93254973 T/C cg25358565 chr5:93447407 FAM172A 1.11 10.98 0.52 4.31e-24 Diabetic retinopathy; CRC cis rs1788820 0.843 rs1788821 chr18:21120869 A/G cg14672496 chr18:21087552 C18orf8 0.54 9.33 0.46 1.62e-18 Body mass index; CRC cis rs79349575 0.715 rs62075844 chr17:47002389 G/A cg00947319 chr17:47005597 UBE2Z -0.34 -5.88 -0.31 9.88e-9 Type 2 diabetes; CRC cis rs9527 0.590 rs943039 chr10:104825132 C/T cg04362960 chr10:104952993 NT5C2 0.58 8.29 0.42 2.82e-15 Arsenic metabolism; CRC cis rs9311474 0.659 rs7638808 chr3:52572056 C/T cg11645453 chr3:52864694 ITIH4 -0.33 -5.99 -0.31 5.63e-9 Electroencephalogram traits; CRC cis rs3106136 0.546 rs4693003 chr4:95145469 A/G cg11021082 chr4:95130006 SMARCAD1 -0.59 -9.34 -0.46 1.45e-18 Capecitabine sensitivity; CRC cis rs889398 0.802 rs12598642 chr16:69848772 A/G cg00738113 chr16:70207722 CLEC18C 0.35 6.01 0.31 5.04e-9 Body mass index; CRC cis rs8078723 0.866 rs7502514 chr17:38188844 A/G cg17344932 chr17:38183730 MED24;SNORD124 0.47 7.35 0.38 1.59e-12 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); CRC cis rs4843747 0.671 rs28679286 chr16:88106307 C/T cg17633681 chr16:88106987 BANP 0.87 16.24 0.67 5.81e-44 Menopause (age at onset); CRC cis rs11608355 0.545 rs56144717 chr12:109902304 T/C cg05360138 chr12:110035743 NA 0.77 8.7 0.43 1.65e-16 Neuroticism; CRC cis rs7914558 1.000 rs7067970 chr10:104913870 C/T cg15744005 chr10:104629667 AS3MT -0.34 -7.27 -0.37 2.57e-12 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs2228479 0.850 rs62054599 chr16:89808850 C/G cg06558623 chr16:89946397 TCF25 1.14 10.79 0.51 1.99e-23 Skin colour saturation; CRC cis rs919433 0.927 rs6759834 chr2:198204860 C/T cg10820045 chr2:198174542 NA -0.49 -7.93 -0.4 3.48e-14 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC cis rs6988636 1.000 rs61422480 chr8:124188940 C/A cg27053337 chr8:124217698 FAM83A 0.46 6.99 0.36 1.58e-11 Urinary uromodulin levels; CRC cis rs11628318 0.614 rs7155883 chr14:103123404 A/C cg08075719 chr14:103021372 NA 0.65 7.6 0.39 3.13e-13 Platelet count; CRC cis rs1552244 1.000 rs2272123 chr3:10140115 G/A cg02579736 chr3:10068473 FANCD2;CIDECP 1.02 13.77 0.6 2.24e-34 Alzheimer's disease; CRC cis rs6968419 0.674 rs57756655 chr7:115927168 C/T cg02561103 chr7:115862891 TES -0.43 -6.26 -0.33 1.19e-9 Intraocular pressure; CRC cis rs4604732 0.527 rs12031949 chr1:247624463 G/T cg02104434 chr1:247694406 LOC148824;OR2C3 0.61 8.94 0.44 2.91e-17 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CRC cis rs9914988 0.943 rs9902953 chr17:27139834 C/A cg12682573 chr17:27188876 MIR451;MIR144 0.58 7.95 0.4 2.99e-14 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs9462027 0.628 rs9469899 chr6:34793124 G/A cg07306190 chr6:34760872 UHRF1BP1 -0.35 -6.06 -0.32 3.69e-9 Systemic lupus erythematosus; CRC cis rs9311474 0.539 rs12489828 chr3:52567014 G/T cg07507251 chr3:52567010 NT5DC2 0.6 10.06 0.49 6.13e-21 Electroencephalogram traits; CRC cis rs236352 0.557 rs9368966 chr6:36825430 A/G cg10099585 chr6:36853529 C6orf89 -0.44 -6.23 -0.32 1.42e-9 Heart rate; CRC trans rs13046373 0.905 rs4816372 chr21:32077414 A/T cg18123596 chr17:36956264 PIP4K2B -0.41 -6.1 -0.32 2.94e-9 HDL cholesterol; CRC cis rs7580658 0.891 rs3768866 chr2:128045415 G/A cg09760422 chr2:128146352 NA -0.37 -7.27 -0.37 2.71e-12 Protein C levels; CRC cis rs3736485 0.966 rs4774595 chr15:51893161 C/T cg08986416 chr15:51914746 DMXL2 -0.48 -6.74 -0.35 7.06e-11 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs769267 0.965 rs2017964 chr19:19387149 T/C cg20644253 chr19:19431407 KIAA0892;SF4 0.43 5.97 0.31 6e-9 Tonsillectomy; CRC cis rs6484504 0.553 rs413067 chr11:31223497 T/C cg14844989 chr11:31128820 NA -0.34 -6.04 -0.32 4.27e-9 Red blood cell count; CRC cis rs4780401 0.609 rs8055247 chr16:11827543 G/A cg01061890 chr16:11836724 TXNDC11 -0.56 -8.02 -0.4 1.91e-14 Rheumatoid arthritis; CRC cis rs2014572 0.967 rs10413671 chr19:57763489 G/A cg12963866 chr19:57752005 ZNF805 -0.41 -6.09 -0.32 3.15e-9 Hyperactive-impulsive symptoms; CRC cis rs1448094 0.935 rs11117120 chr12:86336447 G/A cg18827107 chr12:86230957 RASSF9 -0.38 -6.25 -0.33 1.3e-9 Major depressive disorder; CRC trans rs916888 0.610 rs199438 chr17:44791643 G/A cg01341218 chr17:43662625 NA 0.62 7.73 0.39 1.29e-13 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs782590 0.807 rs782572 chr2:55912120 T/C cg18811423 chr2:55921094 PNPT1 0.88 17.33 0.69 2.92e-48 Metabolic syndrome; CRC cis rs11212617 0.875 rs228597 chr11:108107009 G/A cg12106634 chr11:108092400 ATM;NPAT 0.43 6.32 0.33 8.57e-10 Response to metformin in type 2 diabetes (glycemic); CRC cis rs9649213 0.502 rs6465680 chr7:98005778 A/G cg24562669 chr7:97807699 LMTK2 0.43 7.2 0.37 4.23e-12 Prostate cancer (SNP x SNP interaction); CRC cis rs789859 0.965 rs789858 chr3:194405966 C/T cg21106136 chr3:194405973 FAM43A -0.45 -6.57 -0.34 1.92e-10 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; CRC cis rs77861329 0.748 rs4687607 chr3:52088651 G/A cg08692210 chr3:52188851 WDR51A 0.55 6.4 0.33 5.5e-10 Macrophage inflammatory protein 1b levels; CRC cis rs6499255 0.638 rs57824734 chr16:69811995 C/T cg00738113 chr16:70207722 CLEC18C -0.44 -6.59 -0.34 1.72e-10 IgE levels; CRC cis rs9905704 0.918 rs302868 chr17:56752123 C/T cg12560992 chr17:57184187 TRIM37 0.54 7.49 0.38 6.39e-13 Testicular germ cell tumor; CRC cis rs78456975 0.622 rs11888851 chr2:1518254 C/G cg26248373 chr2:1572462 NA -0.6 -7.4 -0.38 1.13e-12 Placebo response in major depressive disorder (% change in symptom score); CRC cis rs55665837 1.000 rs10832271 chr11:14466919 C/G cg19336497 chr11:14380999 RRAS2 -0.38 -6.54 -0.34 2.29e-10 Vitamin D levels; CRC trans rs9467711 0.606 rs2393667 chr6:26421345 T/C cg06606381 chr12:133084897 FBRSL1 -0.83 -6.42 -0.33 4.83e-10 Autism spectrum disorder or schizophrenia; CRC cis rs798554 0.634 rs6970963 chr7:2821271 C/T cg13628971 chr7:2884303 GNA12 0.44 6.81 0.35 4.63e-11 Height; CRC cis rs3806843 0.576 rs246008 chr5:140338485 C/T cg19875535 chr5:140030758 IK 0.4 6.12 0.32 2.64e-9 Depressive symptoms (multi-trait analysis); CRC cis rs12497850 0.897 rs7373778 chr3:48836392 C/G cg20833759 chr3:49053208 WDR6;DALRD3 0.53 9.21 0.45 4.02e-18 Parkinson's disease; CRC cis rs17780086 0.529 rs7406406 chr17:30220153 T/G cg13647721 chr17:30228624 UTP6 0.61 7.66 0.39 2.03e-13 Height; CRC cis rs1008375 0.966 rs2286773 chr4:17616214 C/A cg02297831 chr4:17616191 MED28 0.46 6.21 0.32 1.58e-9 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs4953076 0.573 rs7595470 chr2:44402467 A/G cg04920474 chr2:44395004 PPM1B 0.58 7.74 0.39 1.27e-13 Height; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg17647863 chr3:127771317 SEC61A1 0.45 6.29 0.33 1.03e-9 Anxiety disorder; CRC cis rs870825 0.616 rs6844588 chr4:185644517 T/G cg04058563 chr4:185651563 MLF1IP 0.72 9.3 0.46 2.04e-18 Blood protein levels; CRC cis rs6951245 1.000 rs113146460 chr7:1105164 C/G cg18402987 chr7:1209562 NA 0.67 7.17 0.37 4.89e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs6973256 0.568 rs7783019 chr7:133347347 A/G cg10665199 chr7:133106180 EXOC4 -0.47 -7.33 -0.37 1.74e-12 Intelligence (multi-trait analysis); CRC cis rs897984 0.568 rs8050107 chr16:30893451 C/T cg02466173 chr16:30829666 NA 0.7 9.05 0.45 1.33e-17 Dementia with Lewy bodies; CRC cis rs3733585 0.605 rs4235354 chr4:10122942 C/A cg11266682 chr4:10021025 SLC2A9 -0.47 -8.44 -0.42 1.02e-15 Cleft plate (environmental tobacco smoke interaction); CRC cis rs6834538 1.000 rs6533627 chr4:113479135 A/G cg10021238 chr4:113569128 MIR367;LARP7 0.44 6.24 0.33 1.32e-9 Free thyroxine concentration; CRC cis rs4689388 0.926 rs4458523 chr4:6289986 G/T cg14416269 chr4:6271139 WFS1 -0.35 -5.73 -0.3 2.26e-8 Type 2 diabetes and other traits;Type 2 diabetes; CRC cis rs17443541 0.507 rs6725254 chr2:200463248 A/C cg03741458 chr2:200468445 NA -0.36 -5.76 -0.3 1.91e-8 Intelligence (multi-trait analysis); CRC cis rs6662572 0.806 rs12047498 chr1:45954632 C/T cg08644498 chr1:46502608 NA 0.41 5.88 0.31 1.02e-8 Blood protein levels; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg26784348 chr1:67520192 SLC35D1 0.39 6.25 0.33 1.25e-9 Liver disease severity in Alagille syndrome; CRC cis rs9488822 0.676 rs13194714 chr6:116394819 T/A cg26893134 chr6:116381904 FRK 0.27 7.71 0.39 1.55e-13 Cholesterol, total;LDL cholesterol; CRC cis rs8177253 0.761 rs1830084 chr3:133508464 A/T cg11941060 chr3:133502564 NA 0.69 12.34 0.56 5.35e-29 Iron status biomarkers; CRC cis rs11098499 0.874 rs6822498 chr4:120120183 T/C cg09307838 chr4:120376055 NA 0.61 8.95 0.44 2.69e-17 Corneal astigmatism; CRC cis rs6076065 0.676 rs6076059 chr20:23336261 C/T cg11657817 chr20:23433608 CST11 0.49 7.33 0.37 1.8e-12 Facial morphology (factor 15, philtrum width); CRC cis rs6952808 0.724 rs7792631 chr7:1982779 C/T cg22963979 chr7:1858916 MAD1L1 -0.55 -7.95 -0.4 3.05e-14 Bipolar disorder and schizophrenia; CRC cis rs7615952 0.641 rs4490307 chr3:125712676 T/G cg02772935 chr3:125709198 NA -0.47 -5.91 -0.31 8.34e-9 Blood pressure (smoking interaction); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg04165910 chr11:208656 BET1L;RIC8A 0.37 6.13 0.32 2.49e-9 Liver disease severity in Alagille syndrome; CRC cis rs17376456 0.877 rs10057814 chr5:93399092 C/G cg09848695 chr5:92956644 FAM172A;MIR2277 0.65 6.22 0.32 1.48e-9 Diabetic retinopathy; CRC cis rs73195822 0.614 rs56259130 chr12:111225650 C/T cg12870014 chr12:110450643 ANKRD13A 0.64 6.92 0.36 2.3e-11 Itch intensity from mosquito bite; CRC cis rs765787 0.530 rs2413786 chr15:45525394 C/A cg24006582 chr15:45444508 DUOX1 -0.56 -8.47 -0.42 8.03e-16 Uric acid levels; CRC cis rs11650494 0.908 rs73340399 chr17:47372743 G/C cg08112188 chr17:47440006 ZNF652 1.13 10.47 0.5 2.49e-22 Prostate cancer; CRC cis rs9326248 0.501 rs4938351 chr11:117022352 A/C cg26566898 chr11:117069891 TAGLN 0.32 6.7 0.35 8.93e-11 Blood protein levels; CRC cis rs4443100 0.670 rs13054331 chr22:23407063 G/A cg14186256 chr22:23484241 RTDR1 0.46 5.87 0.31 1.07e-8 Serum parathyroid hormone levels; CRC cis rs2404602 0.647 rs116090606 chr15:77075209 A/G cg03037974 chr15:76606532 NA -0.56 -8.6 -0.43 3.29e-16 Blood metabolite levels; CRC trans rs7618501 0.516 rs2856236 chr3:50161717 A/C cg21659725 chr3:3221576 CRBN -0.51 -7.69 -0.39 1.72e-13 Intelligence (multi-trait analysis); CRC cis rs7726839 0.561 rs4957050 chr5:579066 A/C cg14541582 chr5:601475 NA -0.32 -6.61 -0.34 1.57e-10 Obesity-related traits; CRC cis rs4727027 0.933 rs757738 chr7:148872351 T/G cg12479418 chr7:148823350 ZNF425;ZNF398 0.43 5.91 0.31 8.45e-9 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC cis rs9399137 0.507 rs28384513 chr6:135376209 T/G cg22676075 chr6:135203613 NA 0.57 8.49 0.42 7.04e-16 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg04215179 chr7:23719682 C7orf46 0.39 6.48 0.34 3.4e-10 Obesity-related traits; CRC cis rs13256369 1.000 rs7004438 chr8:8574379 C/T cg00074818 chr8:8560427 CLDN23 0.35 6.38 0.33 5.93e-10 Obesity-related traits; CRC cis rs6502050 0.835 rs7502548 chr17:80087569 T/C cg02741985 chr17:80059408 CCDC57 -0.44 -7.17 -0.37 4.94e-12 Life satisfaction; CRC cis rs185694 1.000 rs202099 chr13:30896874 C/T cg07600127 chr13:30881527 KATNAL1 -0.57 -6.14 -0.32 2.38e-9 Antineutrophil cytoplasmic antibody-associated vasculitis; CRC trans rs9914544 0.545 rs3803835 chr17:18793061 C/T cg21372672 chr17:16614065 CCDC144A -0.38 -6.1 -0.32 3e-9 Educational attainment (years of education); CRC cis rs1403694 0.695 rs5029975 chr3:186436918 A/G cg04611788 chr3:186434169 KNG1 0.59 8.92 0.44 3.4e-17 Blood protein levels; CRC cis rs1865760 0.663 rs9467656 chr6:25993559 G/A cg17691542 chr6:26056736 HIST1H1C 0.55 8.71 0.43 1.54e-16 Height; CRC cis rs10504229 0.683 rs6995355 chr8:58113870 C/T cg02725872 chr8:58115012 NA -0.65 -11.61 -0.54 2.34e-26 Developmental language disorder (linguistic errors); CRC cis rs780096 0.526 rs4582 chr2:27604279 A/G cg24768116 chr2:27665128 KRTCAP3 -0.35 -7.82 -0.4 7.17e-14 Total body bone mineral density; CRC cis rs6496667 0.779 rs62020693 chr15:90961504 A/G cg04176472 chr15:90893244 GABARAPL3 0.63 8.43 0.42 1.09e-15 Rheumatoid arthritis; CRC cis rs116095464 0.558 rs60251075 chr5:245292 T/C cg22496380 chr5:211416 CCDC127 -0.91 -10.41 -0.5 4.13e-22 Breast cancer; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg26547359 chr10:16859530 RSU1 0.39 6.49 0.34 3.17e-10 Liver disease severity in Alagille syndrome; CRC cis rs853679 0.517 rs9468292 chr6:28095355 G/A cg23161317 chr6:28129485 ZNF389 0.53 6.54 0.34 2.37e-10 Depression; CRC cis rs10927875 0.688 rs2009371 chr1:16348083 A/T cg10494257 chr1:16342123 HSPB7 0.44 5.77 0.3 1.79e-8 Dilated cardiomyopathy; CRC cis rs4974559 0.947 rs10018627 chr4:1356358 G/A cg02980000 chr4:1222292 CTBP1 0.72 8.05 0.41 1.49e-14 Systolic blood pressure; CRC cis rs3617 0.572 rs2256332 chr3:52855865 A/G cg15147215 chr3:52552868 STAB1 0.53 9.2 0.45 4.13e-18 Red blood cell count;Autism spectrum disorder or schizophrenia; CRC trans rs1814175 0.616 rs10839388 chr11:49842603 C/T cg21153622 chr11:89784906 NA -0.4 -6.25 -0.33 1.28e-9 Height; CRC cis rs3858526 0.874 rs10838879 chr11:5950169 C/T cg02574844 chr11:5959923 NA -0.46 -6.45 -0.33 4.08e-10 DNA methylation (variation); CRC cis rs7224685 0.501 rs11650023 chr17:4012850 C/T cg05562828 chr17:3906858 NA -0.65 -11.36 -0.53 1.84e-25 Type 2 diabetes; CRC trans rs2228479 0.850 rs1800331 chr16:89858417 C/A cg24644049 chr4:85504048 CDS1 0.78 6.59 0.34 1.79e-10 Skin colour saturation; CRC cis rs7312933 0.558 rs11181501 chr12:42822671 G/A cg11827402 chr12:42719852 PPHLN1;ZCRB1 0.66 9.68 0.47 1.13e-19 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CRC trans rs68151129 0.666 rs60277420 chr13:94996400 G/A cg24755503 chr5:140706252 NA 0.77 6.06 0.32 3.81e-9 Lower facial height; CRC cis rs11608355 0.545 rs11615336 chr12:109914802 C/A cg05360138 chr12:110035743 NA 0.78 8.76 0.43 1.07e-16 Neuroticism; CRC cis rs2845885 1.000 rs11231698 chr11:63877163 C/T cg24431193 chr11:63883947 FLRT1;MACROD1 0.71 5.83 0.31 1.33e-8 Body mass index; CRC cis rs2976388 0.609 rs2572907 chr8:143801938 G/A cg05569086 chr8:143859399 LYNX1 0.37 6.35 0.33 7.33e-10 Urinary tract infection frequency; CRC cis rs6691722 0.503 rs3765431 chr1:24706410 T/C cg18323236 chr1:24743029 NIPAL3 0.38 5.68 0.3 2.9e-8 Response to interferon beta in multiple sclerosis; CRC cis rs1552244 1.000 rs35993975 chr3:10067794 A/G cg18598329 chr3:10140678 FANCD2;C3orf24 -0.83 -9.58 -0.47 2.56e-19 Alzheimer's disease; CRC cis rs597583 0.709 rs7940527 chr11:117398202 C/G cg27161313 chr11:117392002 DSCAML1 0.4 5.87 0.31 1.04e-8 Putamen volume; CRC cis rs12701220 0.655 rs34696066 chr7:1140919 C/T cg04498913 chr7:1135747 C7orf50 -0.49 -5.91 -0.31 8.58e-9 Bronchopulmonary dysplasia; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg12530254 chr20:17949265 C20orf72;SNX5 0.47 6.79 0.35 5.15e-11 Intelligence (multi-trait analysis); CRC trans rs1005277 0.541 rs1740741 chr10:38515334 C/T cg17830980 chr10:43048298 ZNF37B -0.57 -9.68 -0.47 1.16e-19 Extrinsic epigenetic age acceleration; CRC cis rs7932354 0.583 rs2070851 chr11:46744528 T/C cg19486271 chr11:47235900 DDB2 0.45 5.85 0.31 1.16e-8 Bone mineral density (hip);Bone mineral density; CRC cis rs2070488 0.689 rs6809352 chr3:38544349 G/A cg01465620 chr3:38496096 LOC100128640;ACVR2B -0.69 -11.39 -0.53 1.47e-25 Electrocardiographic conduction measures; CRC cis rs950776 0.642 rs12905641 chr15:78964362 A/G cg06917634 chr15:78832804 PSMA4 -0.46 -6.99 -0.36 1.56e-11 Sudden cardiac arrest; CRC cis rs11122272 0.735 rs2491403 chr1:231511185 C/T cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.54 -8.11 -0.41 1.04e-14 Hemoglobin concentration; CRC cis rs9911578 1.000 rs1494977 chr17:56863064 C/T cg12560992 chr17:57184187 TRIM37 0.9 16.37 0.67 1.7e-44 Intelligence (multi-trait analysis); CRC cis rs6684514 1.000 rs3806408 chr1:156252137 C/A cg16558208 chr1:156270281 VHLL 0.58 9.04 0.45 1.34e-17 Mean corpuscular hemoglobin concentration;Glycated hemoglobin levels; CRC cis rs6076065 0.962 rs1003417 chr20:23348007 T/A cg11657817 chr20:23433608 CST11 0.36 5.61 0.3 4.27e-8 Facial morphology (factor 15, philtrum width); CRC cis rs11031096 0.503 rs10835604 chr11:4109709 A/T cg18678763 chr11:4115507 RRM1 -0.54 -8.54 -0.43 5.04e-16 Mean corpuscular volume;Mean corpuscular hemoglobin; CRC cis rs11711311 1.000 rs12636577 chr3:113497507 A/G cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.52 -7.03 -0.36 1.17e-11 IgG glycosylation; CRC cis rs7617773 0.780 rs35297395 chr3:48342882 C/T cg11946769 chr3:48343235 NME6 0.72 9.63 0.47 1.74e-19 Coronary artery disease; CRC cis rs7849270 1.000 rs6478867 chr9:131903923 A/C cg13538475 chr9:131942899 NA 0.32 6.34 0.33 7.66e-10 Blood metabolite ratios; CRC cis rs875971 1.000 rs7789768 chr7:65938980 A/C cg18876405 chr7:65276391 NA 0.52 8.85 0.44 5.32e-17 Aortic root size; CRC cis rs6662572 0.737 rs11584814 chr1:46504389 G/A cg08644498 chr1:46502608 NA 0.47 7.6 0.39 3.08e-13 Blood protein levels; CRC cis rs12497850 0.931 rs6414613 chr3:49035885 C/T cg07636037 chr3:49044803 WDR6 1.02 18.41 0.71 1.52e-52 Parkinson's disease; CRC cis rs12497850 0.863 rs4974084 chr3:48939080 G/A cg20833759 chr3:49053208 WDR6;DALRD3 0.52 8.77 0.44 9.76e-17 Parkinson's disease; CRC cis rs9322193 0.923 rs10747275 chr6:149943918 C/T cg13206674 chr6:150067644 NUP43 0.64 9.56 0.47 2.92e-19 Lung cancer; CRC cis rs6496667 0.632 rs6496658 chr15:90884105 A/G cg22089800 chr15:90895588 ZNF774 0.43 6.41 0.33 5.03e-10 Rheumatoid arthritis; CRC cis rs58688157 0.549 rs11246192 chr11:572473 T/C cg01842473 chr11:617407 IRF7;MUPCDH -0.49 -6.48 -0.34 3.42e-10 Systemic lupus erythematosus; CRC cis rs62064224 0.589 rs2041306 chr17:30665675 T/C cg25809561 chr17:30822961 MYO1D 0.54 9.44 0.46 7.05e-19 Schizophrenia; CRC cis rs2836950 0.565 rs2836926 chr21:40536790 G/A cg06238570 chr21:40685208 BRWD1 -0.61 -8.95 -0.44 2.63e-17 Menarche (age at onset); CRC cis rs9399135 0.660 rs4440481 chr6:135276696 A/G cg24558204 chr6:135376177 HBS1L 0.53 7.98 0.4 2.39e-14 Red blood cell count; CRC cis rs7772486 0.875 rs10872583 chr6:146396699 G/T cg13319975 chr6:146136371 FBXO30 0.38 5.69 0.3 2.84e-8 Lobe attachment (rater-scored or self-reported); CRC cis rs875971 0.862 rs12698521 chr7:65939489 T/C cg18876405 chr7:65276391 NA 0.52 8.85 0.44 5.32e-17 Aortic root size; CRC cis rs9914988 0.832 rs12946132 chr17:27157362 T/C cg20469991 chr17:27169893 C17orf63 -0.59 -7.19 -0.37 4.48e-12 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs11098499 0.954 rs7654587 chr4:120388406 C/T cg24375607 chr4:120327624 NA 0.5 7.72 0.39 1.4e-13 Corneal astigmatism; CRC cis rs4481887 0.790 rs7546964 chr1:248414960 A/G cg00666640 chr1:248458726 OR2T12 0.46 7.78 0.39 9.16e-14 Common traits (Other); CRC trans rs561341 1.000 rs527256 chr17:30321293 C/G cg20587970 chr11:113659929 NA -1.43 -20.38 -0.75 2.82e-60 Hip circumference adjusted for BMI; CRC cis rs67340775 0.541 rs200965 chr6:27866384 G/A cg08798685 chr6:27730294 NA -0.54 -5.86 -0.31 1.13e-8 Lung cancer in ever smokers; CRC cis rs6570726 0.620 rs367693 chr6:145815949 G/A cg05347473 chr6:146136440 FBXO30 0.49 7.13 0.37 6.28e-12 Lobe attachment (rater-scored or self-reported); CRC cis rs12620999 1.000 rs4377286 chr2:238069686 C/T cg23555395 chr2:238036564 NA -0.62 -9.68 -0.47 1.12e-19 Systemic lupus erythematosus; CRC cis rs887829 0.570 rs11680450 chr2:234597483 T/C cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.47 -7.26 -0.37 2.77e-12 Metabolic traits;Bilirubin levels;Cholelithiasis-related traits in sickle cell anemia;Metabolite levels;Total bilirubin levels in HIV-1 infection;Serum metabolite levels;Blood metabolite levels; CRC cis rs9910055 0.529 rs228764 chr17:42185469 A/G cg13607699 chr17:42295918 UBTF -0.45 -5.99 -0.31 5.51e-9 Total body bone mineral density; CRC cis rs989128 0.614 rs8077587 chr17:48626575 C/T cg24438145 chr17:48624694 SPATA20 0.52 7.41 0.38 1.04e-12 Type 2 diabetes; CRC cis rs2976388 0.609 rs2717605 chr8:143801015 T/G cg20041105 chr8:143859282 LYNX1 0.43 7.63 0.39 2.58e-13 Urinary tract infection frequency; CRC cis rs6088580 0.634 rs4911420 chr20:32998654 A/G cg08999081 chr20:33150536 PIGU -0.59 -11.34 -0.53 2.18e-25 Glomerular filtration rate (creatinine); CRC cis rs9308731 0.644 rs10189015 chr2:111918472 G/A cg04202892 chr2:111875749 ACOXL 0.48 7.81 0.4 7.55e-14 Chronic lymphocytic leukemia; CRC cis rs11212617 0.837 rs2070661 chr11:108043988 C/T cg12106634 chr11:108092400 ATM;NPAT 0.39 5.73 0.3 2.32e-8 Response to metformin in type 2 diabetes (glycemic); CRC cis rs3785574 0.962 rs62077483 chr17:61806380 C/T cg06601766 chr17:61851465 DDX42;CCDC47 0.58 8.33 0.42 2.29e-15 Height; CRC cis rs3750082 0.889 rs6962267 chr7:32939774 G/A cg05721444 chr7:32995514 FKBP9 0.48 7.22 0.37 3.62e-12 Glomerular filtration rate (creatinine); CRC cis rs8016982 0.698 rs8011097 chr14:81702736 T/C cg01989461 chr14:81687754 GTF2A1 0.55 8.69 0.43 1.7e-16 Schizophrenia; CRC cis rs875971 0.862 rs6460307 chr7:66060871 A/G cg18876405 chr7:65276391 NA 0.51 8.25 0.41 3.86e-15 Aortic root size; CRC cis rs7772486 0.754 rs702318 chr6:146005873 G/T cg23711669 chr6:146136114 FBXO30 -0.75 -12.39 -0.56 3.52e-29 Lobe attachment (rater-scored or self-reported); CRC cis rs12410462 0.748 rs1495853 chr1:227657336 A/G cg04117972 chr1:227635322 NA -0.51 -5.83 -0.31 1.32e-8 Major depressive disorder; CRC cis rs7901135 0.924 rs1992658 chr10:60581358 G/A cg23799393 chr10:60588674 BICC1 0.36 5.69 0.3 2.82e-8 Morning vs. evening chronotype; CRC cis rs6502050 0.835 rs8078795 chr17:80126320 C/T cg09264619 chr17:80180166 NA -0.35 -5.84 -0.31 1.27e-8 Life satisfaction; CRC cis rs11792861 0.926 rs58795279 chr9:111851902 A/T cg05043794 chr9:111880884 C9orf5 -0.36 -6.61 -0.34 1.51e-10 Menarche (age at onset); CRC cis rs1862618 0.671 rs2591965 chr5:56236176 T/C cg12311346 chr5:56204834 C5orf35 0.66 9.87 0.48 2.8e-20 Initial pursuit acceleration; CRC cis rs501120 0.584 rs1704221 chr10:44710930 G/A cg09554077 chr10:44749378 NA 0.65 7.29 0.37 2.37e-12 Coronary artery disease;Coronary heart disease; CRC cis rs1218582 0.744 rs6674853 chr1:154892753 G/C cg03351412 chr1:154909251 PMVK 0.53 7.93 0.4 3.48e-14 Prostate cancer; CRC cis rs17685 0.523 rs10246583 chr7:75746667 C/A cg16489192 chr7:75678113 MDH2;STYXL1 -0.36 -5.65 -0.3 3.5e-8 Coffee consumption;Coffee consumption (cups per day); CRC cis rs1511802 0.501 rs7684025 chr4:187116227 C/T cg24794857 chr4:187113578 CYP4V2 0.43 6.57 0.34 1.94e-10 Blood protein levels; CRC cis rs3540 0.597 rs1978151 chr15:91037300 C/T cg22089800 chr15:90895588 ZNF774 0.56 9.16 0.45 5.9e-18 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; CRC cis rs6502050 0.835 rs66531647 chr17:80089022 G/T cg11859384 chr17:80120422 CCDC57 -0.37 -5.92 -0.31 7.94e-9 Life satisfaction; CRC cis rs13382862 0.895 rs2289082 chr2:20881958 A/T cg07755735 chr2:20870362 GDF7 0.31 5.82 0.31 1.4e-8 Abdominal aortic aneurysm; CRC cis rs2404602 0.716 rs67888330 chr15:76752483 A/G cg03037974 chr15:76606532 NA 0.73 13.27 0.59 1.76e-32 Blood metabolite levels; CRC cis rs1030877 0.960 rs3792050 chr2:105902255 T/C cg02079111 chr2:105885981 TGFBRAP1 -0.62 -10.29 -0.49 1.05e-21 Obesity-related traits; CRC cis rs12148488 0.816 rs4886655 chr15:75385568 C/T cg17294928 chr15:75287854 SCAMP5 0.49 7.48 0.38 6.84e-13 Caffeine consumption; CRC cis rs17152411 1.000 rs7083298 chr10:126590691 T/C cg07906193 chr10:126599966 NA 0.58 6.52 0.34 2.69e-10 Height; CRC trans rs11581859 0.950 rs56240617 chr1:99373488 T/C cg12183875 chr3:169587454 LRRC31 0.27 6.43 0.33 4.37e-10 Response to cognitive-behavioural therapy in anxiety disorder; CRC cis rs10540 1.000 rs61876334 chr11:487201 T/C cg21784768 chr11:537496 LRRC56 -0.66 -6.13 -0.32 2.48e-9 Body mass index; CRC cis rs12142240 0.698 rs66483119 chr1:46838389 T/C cg00530320 chr1:46809349 NSUN4 0.6 8.14 0.41 8.41e-15 Menopause (age at onset); CRC cis rs2933343 0.700 rs2249514 chr3:128643812 C/T cg11901034 chr3:128598214 ACAD9 -0.56 -8.15 -0.41 7.47e-15 IgG glycosylation; CRC cis rs9487051 0.802 rs9487039 chr6:109610163 A/T cg12927641 chr6:109611667 NA -0.38 -6.97 -0.36 1.78e-11 Reticulocyte fraction of red cells; CRC cis rs2243480 1.000 rs4718317 chr7:65648901 A/G cg18252515 chr7:66147081 NA 1.16 13.7 0.6 4.1e-34 Diabetic kidney disease; CRC cis rs868943 0.743 rs13192924 chr6:116352332 T/C cg18764771 chr6:116381957 FRK 0.26 6.35 0.33 7.26e-10 Total cholesterol levels; CRC cis rs13064411 0.542 rs2399477 chr3:113222998 A/G cg18753928 chr3:113234510 CCDC52 -0.53 -8.13 -0.41 8.8e-15 Response to simvastatin treatment (PCSK9 protein level change); CRC cis rs12476592 0.543 rs262512 chr2:63890260 T/C cg10828910 chr2:63850056 LOC388955 0.5 6.24 0.33 1.37e-9 Childhood ear infection; CRC cis rs9858542 0.953 rs10640 chr3:49454277 G/A cg07274523 chr3:49395745 GPX1 0.47 6.34 0.33 7.73e-10 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC trans rs7267979 1.000 rs4815417 chr20:25379526 C/T cg17903999 chr18:56338584 MALT1 0.42 7.23 0.37 3.41e-12 Liver enzyme levels (alkaline phosphatase); CRC cis rs4132509 1.000 rs10927059 chr1:243852079 T/C cg21452805 chr1:244014465 NA 0.49 6.63 0.34 1.4e-10 RR interval (heart rate); CRC cis rs477895 1.000 rs7939107 chr11:64034773 C/T cg19465662 chr11:63993652 NUDT22;TRPT1 0.7 7.45 0.38 8.53e-13 Mean platelet volume; CRC cis rs9467773 0.595 rs7767847 chr6:26597893 A/T cg09904177 chr6:26538194 HMGN4 0.73 11.56 0.54 3.49e-26 Intelligence (multi-trait analysis); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg02232284 chr6:168120876 NA -0.36 -6.3 -0.33 9.64e-10 Liver disease severity in Alagille syndrome; CRC cis rs10504229 0.683 rs11786843 chr8:58133629 T/C cg05313129 chr8:58192883 C8orf71 -0.45 -6.27 -0.33 1.12e-9 Developmental language disorder (linguistic errors); CRC cis rs4731207 0.698 rs10250911 chr7:124473034 G/A cg23710748 chr7:124431027 NA 0.38 6.08 0.32 3.42e-9 Cutaneous malignant melanoma; CRC cis rs9916302 0.706 rs8067511 chr17:37611352 C/T cg15445000 chr17:37608096 MED1 0.34 5.85 0.31 1.16e-8 Glomerular filtration rate (creatinine); CRC cis rs1448094 0.556 rs11614513 chr12:86167756 G/C cg19622623 chr12:86230825 RASSF9 -0.37 -5.64 -0.3 3.62e-8 Major depressive disorder; CRC cis rs1881797 1.000 rs7527856 chr1:247688139 C/T cg21399703 chr1:247681439 NA 0.45 7.38 0.38 1.33e-12 Acute lymphoblastic leukemia (childhood); CRC cis rs335206 1.000 rs335205 chr5:122504682 A/C cg16368670 chr5:122501738 PRDM6 -0.3 -5.82 -0.31 1.36e-8 QRS duration; CRC cis rs9359856 0.517 rs112527288 chr6:90509141 C/T cg13799429 chr6:90582589 CASP8AP2 -0.73 -8.2 -0.41 5.3e-15 Bipolar disorder; CRC cis rs13108904 0.652 rs2878539 chr4:1243877 C/T cg16405210 chr4:1374714 KIAA1530 -0.43 -6.34 -0.33 7.67e-10 Obesity-related traits; CRC trans rs2303319 0.504 rs12469302 chr2:162433831 G/T cg18122310 chr12:50236657 BCDIN3D -0.75 -6.24 -0.33 1.33e-9 Cognitive function; CRC cis rs7772486 0.754 rs4360151 chr6:146255079 A/C cg13319975 chr6:146136371 FBXO30 0.39 5.93 0.31 7.81e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs9039 1.000 rs9039 chr16:9205363 A/G cg08831531 chr16:9218945 NA -0.56 -7.36 -0.38 1.44e-12 Menopause (age at onset); CRC cis rs2019137 0.560 rs7578633 chr2:113978650 C/T cg07594247 chr2:113993304 PAX8;LOC440839;LOC654433 0.5 7.51 0.38 5.7e-13 Lymphocyte counts; CRC cis rs1451375 0.617 rs745043 chr7:50543955 T/G cg14593290 chr7:50529359 DDC -0.63 -8.31 -0.42 2.63e-15 Malaria; CRC trans rs11039798 0.557 rs4441015 chr11:49027070 A/G cg03929089 chr4:120376271 NA 0.65 6.71 0.35 8.74e-11 Axial length; CRC cis rs6502050 0.805 rs4789740 chr17:80119202 T/C cg09264619 chr17:80180166 NA -0.35 -5.81 -0.31 1.48e-8 Life satisfaction; CRC cis rs4713118 0.869 rs6914924 chr6:27711530 C/T cg03623178 chr6:28175578 NA 0.66 9.34 0.46 1.46e-18 Parkinson's disease; CRC cis rs7927771 1.000 rs7105282 chr11:47805614 C/A cg05585544 chr11:47624801 NA -0.62 -10.82 -0.51 1.47e-23 Subjective well-being; CRC cis rs1150668 0.835 rs1233696 chr6:28143010 T/C cg12273811 chr6:28175739 NA 0.46 6.93 0.36 2.18e-11 Pubertal anthropometrics; CRC cis rs1552244 1.000 rs6782602 chr3:10116541 G/T cg13047869 chr3:10149882 C3orf24 0.53 7.44 0.38 8.73e-13 Alzheimer's disease; CRC cis rs6089584 0.888 rs6587283 chr20:60613727 A/C cg13770153 chr20:60521292 NA -0.59 -8.8 -0.44 7.79e-17 Body mass index; CRC cis rs1223397 1.000 rs1223403 chr6:13271812 G/A cg07912922 chr6:13274314 PHACTR1 0.53 6.52 0.34 2.66e-10 Blood pressure; CRC cis rs7584330 0.504 rs6712927 chr2:238427808 G/A cg14458575 chr2:238380390 NA 0.41 5.9 0.31 8.8e-9 Prostate cancer; CRC trans rs7937682 0.889 rs479667 chr11:111484034 C/T cg18187862 chr3:45730750 SACM1L 0.47 6.78 0.35 5.68e-11 Primary sclerosing cholangitis; CRC trans rs948562 0.947 rs78176302 chr11:58382649 A/T cg26660744 chr1:1573181 CDK11B 0.54 6.1 0.32 2.94e-9 Lymphoma; CRC cis rs10911232 0.507 rs4652772 chr1:183023696 C/G ch.1.3577855R chr1:183094577 LAMC1 -0.83 -14.11 -0.61 1.06e-35 Hypertriglyceridemia; CRC cis rs9467773 1.000 rs2208331 chr6:26507319 A/G cg09904177 chr6:26538194 HMGN4 0.85 14.75 0.63 3.95e-38 Intelligence (multi-trait analysis); CRC cis rs9322193 0.847 rs880246 chr6:150167108 G/A cg00933542 chr6:150070202 PCMT1 0.35 7.24 0.37 3.25e-12 Lung cancer; CRC cis rs7215564 0.908 rs34710385 chr17:78676494 G/A cg09596252 chr17:78655493 RPTOR 0.55 6.09 0.32 3.09e-9 Myopia (pathological); CRC cis rs11098499 0.866 rs72676074 chr4:120359841 A/C cg24375607 chr4:120327624 NA 0.52 8.06 0.41 1.43e-14 Corneal astigmatism; CRC cis rs7618915 0.571 rs6778844 chr3:52596398 C/T cg18404041 chr3:52824283 ITIH1 0.42 8.47 0.42 8.02e-16 Bipolar disorder; CRC cis rs3772130 0.603 rs35489993 chr3:121411876 A/C cg20356878 chr3:121714668 ILDR1 0.37 6.03 0.32 4.3e-9 Cognitive performance; CRC cis rs11190604 1.000 rs75063298 chr10:102213600 C/A cg16342193 chr10:102329863 NA -0.37 -6.1 -0.32 2.96e-9 Palmitoleic acid (16:1n-7) levels; CRC cis rs4722166 0.532 rs1404008 chr7:22756000 A/T cg05472934 chr7:22766657 IL6 0.68 10.66 0.51 5.67e-23 Lung cancer; CRC cis rs796364 0.715 rs11688872 chr2:201052418 C/T cg25936922 chr2:200820526 C2orf60;C2orf47 -0.65 -5.95 -0.31 7.02e-9 Schizophrenia; CRC cis rs1707322 0.686 rs61784833 chr1:46233772 T/C cg03146154 chr1:46216737 IPP 0.66 9.52 0.46 3.97e-19 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC trans rs11039798 0.582 rs1304193 chr11:48688588 C/T cg15704280 chr7:45808275 SEPT13 0.66 6.81 0.35 4.72e-11 Axial length; CRC trans rs7615952 0.932 rs7630077 chr3:125649676 T/C cg02007433 chr3:129722099 NA -0.44 -6.02 -0.31 4.6e-9 Blood pressure (smoking interaction); CRC cis rs12142240 0.698 rs9661240 chr1:46827050 G/A cg14993813 chr1:46806288 NSUN4 -0.49 -6.22 -0.32 1.55e-9 Menopause (age at onset); CRC cis rs8060686 0.623 rs2418736 chr16:68154862 A/G cg26727032 chr16:67993705 SLC12A4 0.6 9.68 0.47 1.18e-19 HDL cholesterol;Metabolic syndrome; CRC cis rs7917772 0.503 rs2031602 chr10:104307955 G/C cg04362960 chr10:104952993 NT5C2 -0.41 -5.94 -0.31 7.31e-9 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC cis rs11758351 0.660 rs77130538 chr6:26210723 T/C cg10723962 chr6:26240782 HIST1H4F -0.39 -6.26 -0.33 1.23e-9 Gout;Renal underexcretion gout; CRC cis rs1153858 0.621 rs1706824 chr15:45579948 C/T cg21132104 chr15:45694354 SPATA5L1 0.53 7.13 0.37 6.5e-12 Homoarginine levels; CRC cis rs3736485 0.966 rs7177471 chr15:51911232 C/T cg08986416 chr15:51914746 DMXL2 -0.45 -6.38 -0.33 6.15e-10 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs1707322 1.000 rs11211243 chr1:46455433 G/C cg06784218 chr1:46089804 CCDC17 0.52 9.22 0.45 3.7e-18 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs3806843 0.900 rs2337983 chr5:140136808 G/A cg19875535 chr5:140030758 IK -0.59 -9.64 -0.47 1.52e-19 Depressive symptoms (multi-trait analysis); CRC cis rs3806843 0.838 rs2337514 chr5:140132732 T/C cg19875535 chr5:140030758 IK -0.53 -8.41 -0.42 1.22e-15 Depressive symptoms (multi-trait analysis); CRC cis rs7605378 1.000 rs7577763 chr2:200681753 C/T cg23649088 chr2:200775458 C2orf69 0.58 8.17 0.41 6.54e-15 Osteoporosis; CRC cis rs798554 1.000 rs798550 chr7:2760609 A/G cg13628971 chr7:2884303 GNA12 0.48 6.82 0.35 4.33e-11 Height; CRC cis rs853679 0.550 rs1150689 chr6:28165099 T/C cg25164649 chr6:28176230 NA 0.79 11.08 0.52 1.9e-24 Depression; CRC cis rs11955398 0.625 rs6449485 chr5:59995441 C/T cg02684056 chr5:59996105 DEPDC1B 0.43 6.12 0.32 2.71e-9 Intelligence (multi-trait analysis); CRC cis rs9341808 0.667 rs1575541 chr6:80917485 T/A cg08355045 chr6:80787529 NA 0.33 5.77 0.3 1.81e-8 Sitting height ratio; CRC trans rs2243480 1.000 rs34815098 chr7:65292254 A/C cg10756647 chr7:56101905 PSPH 0.74 7.77 0.39 9.91e-14 Diabetic kidney disease; CRC trans rs7267979 1.000 rs8125868 chr20:25324410 A/G cg17903999 chr18:56338584 MALT1 0.41 6.69 0.35 9.46e-11 Liver enzyme levels (alkaline phosphatase); CRC cis rs6866344 0.570 rs1071882 chr5:178136040 C/T cg03877680 chr5:178157825 ZNF354A 0.75 11.01 0.52 3.26e-24 Neutrophil percentage of white cells; CRC cis rs7493 0.853 rs2299266 chr7:95049073 A/G cg07404485 chr7:94953653 PON1 -0.47 -6.12 -0.32 2.62e-9 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs595982 0.527 rs12151238 chr19:49368613 T/C cg21252483 chr19:49399788 TULP2 -0.36 -5.93 -0.31 7.76e-9 Red cell distribution width; CRC cis rs11764590 0.694 rs4721359 chr7:2104951 A/G cg02825527 chr7:2087843 MAD1L1 -0.4 -5.62 -0.3 4.15e-8 Neuroticism; CRC cis rs12497850 0.829 rs8926 chr3:49052785 T/A cg07636037 chr3:49044803 WDR6 1.05 18.53 0.71 5.16e-53 Parkinson's disease; CRC trans rs10838798 0.584 rs4752899 chr11:48141855 T/G cg21153622 chr11:89784906 NA -0.42 -6.54 -0.34 2.41e-10 Height; CRC cis rs9399137 0.507 rs35571217 chr6:135290355 T/C cg22676075 chr6:135203613 NA 0.58 8.76 0.43 1.03e-16 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; CRC cis rs13191362 1.000 rs34344906 chr6:162993378 T/C cg23758597 chr6:163146217 PARK2 -0.56 -6.18 -0.32 1.93e-9 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs13108904 0.870 rs13132584 chr4:1251504 G/T cg19318889 chr4:1322082 MAEA 0.41 5.95 0.31 6.97e-9 Obesity-related traits; CRC trans rs2303319 0.504 rs62189052 chr2:162623869 C/G cg22677401 chr17:46026860 NA -0.67 -6.09 -0.32 3.14e-9 Cognitive function; CRC cis rs6748734 0.894 rs4675869 chr2:241827696 A/G cg16358738 chr2:241808595 AGXT -0.39 -5.93 -0.31 7.52e-9 Urinary metabolites; CRC cis rs11148252 0.740 rs9596643 chr13:52912380 G/A cg12458913 chr13:53173898 NA -0.49 -7.28 -0.37 2.49e-12 Lewy body disease; CRC cis rs7647973 0.925 rs4384984 chr3:49289878 T/G cg20833759 chr3:49053208 WDR6;DALRD3 0.53 8.09 0.41 1.13e-14 Menarche (age at onset); CRC cis rs7258465 1.000 rs34256197 chr19:18606472 G/A cg06953865 chr19:18549723 ISYNA1 -0.38 -5.74 -0.3 2.16e-8 Breast cancer; CRC cis rs1552244 0.572 rs57268864 chr3:10164233 C/A cg00166722 chr3:10149974 C3orf24 0.65 7.7 0.39 1.56e-13 Alzheimer's disease; CRC cis rs4718428 0.705 rs68168107 chr7:66255238 G/A cg12165864 chr7:66369176 NA -0.42 -5.73 -0.3 2.3e-8 Corneal structure; CRC cis rs10504229 0.679 rs72649115 chr8:58037631 T/G cg02725872 chr8:58115012 NA -0.51 -6.9 -0.36 2.64e-11 Developmental language disorder (linguistic errors); CRC cis rs875971 0.545 rs11767262 chr7:65767224 T/A cg05627663 chr7:65219948 SNORA22;CCT6P1 0.57 7.42 0.38 1.03e-12 Aortic root size; CRC cis rs7616330 0.836 rs73118214 chr3:71047396 A/C cg01511742 chr3:71112437 FOXP1 -0.52 -6.22 -0.32 1.54e-9 QT interval; CRC cis rs16975963 0.644 rs111694872 chr19:38046331 T/C cg15135657 chr19:38346511 NA -0.45 -6.25 -0.33 1.25e-9 Longevity; CRC cis rs634534 0.622 rs1192168 chr11:65730945 T/G cg26695010 chr11:65641043 EFEMP2 -0.39 -6.08 -0.32 3.37e-9 Sum eosinophil basophil counts;Eosinophil counts; CRC cis rs9768139 0.524 rs7779175 chr7:158136918 C/T cg24154853 chr7:158122151 PTPRN2 -0.47 -7.11 -0.36 7.48e-12 Calcium levels; CRC cis rs9787249 0.874 rs12094291 chr1:40226046 G/A cg02773041 chr1:40204384 PPIE 0.62 9.26 0.45 2.78e-18 Blood protein levels; CRC cis rs9611565 0.512 rs139571 chr22:42214238 G/A cg06634786 chr22:41940651 POLR3H -0.72 -7.91 -0.4 3.89e-14 Vitiligo; CRC cis rs35110281 0.720 rs162394 chr21:44943550 C/G cg01579765 chr21:45077557 HSF2BP 0.35 6.59 0.34 1.76e-10 Mean corpuscular volume; CRC cis rs7107174 1.000 rs2512537 chr11:77971947 T/C cg02023728 chr11:77925099 USP35 0.52 7.37 0.38 1.43e-12 Testicular germ cell tumor; CRC cis rs6502050 0.835 rs34867501 chr17:80121358 T/C cg09264619 chr17:80180166 NA -0.35 -5.93 -0.31 7.47e-9 Life satisfaction; CRC cis rs2839186 0.500 rs13049893 chr21:47707054 C/T cg09417038 chr21:47716443 C21orf57 -0.55 -9.03 -0.45 1.44e-17 Testicular germ cell tumor; CRC cis rs8058578 0.887 rs28421305 chr16:30838128 G/A cg00531865 chr16:30841666 NA -0.47 -6.29 -0.33 1.03e-9 Multiple myeloma; CRC cis rs4132509 0.947 rs10927041 chr1:243731890 T/C cg21452805 chr1:244014465 NA 0.47 6.42 0.33 4.74e-10 RR interval (heart rate); CRC cis rs4731207 0.569 rs75791754 chr7:124464917 C/T cg23710748 chr7:124431027 NA 0.39 6.23 0.32 1.43e-9 Cutaneous malignant melanoma; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg23601523 chr16:68119098 NFATC3 0.48 6.8 0.35 4.92e-11 Response to antipsychotic treatment; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg16266895 chr12:101674004 UTP20 0.43 6.35 0.33 7.08e-10 Intelligence (multi-trait analysis); CRC cis rs9381040 1.000 rs2093396 chr6:41155000 G/A cg03526776 chr6:41159608 TREML2 0.44 7.55 0.38 4.39e-13 Alzheimer's disease (late onset); CRC cis rs875971 0.522 rs9530 chr7:65425894 A/G cg05627663 chr7:65219948 SNORA22;CCT6P1 0.47 6.82 0.35 4.34e-11 Aortic root size; CRC cis rs7932354 0.528 rs12796744 chr11:47132724 A/T cg19486271 chr11:47235900 DDB2 0.52 7.96 0.4 2.74e-14 Bone mineral density (hip);Bone mineral density; CRC cis rs1150668 0.796 rs9468372 chr6:28379361 T/A cg21251018 chr6:28226885 NKAPL 0.45 7.7 0.39 1.65e-13 Pubertal anthropometrics; CRC cis rs6563842 0.563 rs9603786 chr13:41316364 G/A cg21288729 chr13:41239152 FOXO1 0.43 6.73 0.35 7.72e-11 Eosinophil percentage of granulocytes;Sum eosinophil basophil counts;Eosinophil percentage of white cells; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg19959005 chr18:19180920 ESCO1 0.44 5.98 0.31 5.87e-9 Anxiety disorder; CRC trans rs7615952 0.512 rs2979351 chr3:125363599 C/T cg17147758 chr8:6949321 NA -0.52 -7.18 -0.37 4.82e-12 Blood pressure (smoking interaction); CRC cis rs713587 0.563 rs1529897 chr2:25086827 T/G cg04586622 chr2:25135609 ADCY3 -0.61 -11.64 -0.54 1.92e-26 Body mass index in non-asthmatics; CRC cis rs4604732 0.631 rs34330532 chr1:247626844 G/C cg12754571 chr1:247694271 LOC148824;OR2C3 0.41 5.78 0.3 1.74e-8 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CRC cis rs910316 0.763 rs1548807 chr14:75479582 T/G cg11812906 chr14:75593930 NEK9 0.55 8.55 0.43 4.73e-16 Height; CRC cis rs4555082 0.874 rs2816612 chr14:105723103 C/T cg06808227 chr14:105710500 BRF1 -0.62 -8.83 -0.44 6.31e-17 Mean platelet volume;Platelet distribution width; CRC cis rs7914558 1.000 rs3740387 chr10:104849468 G/A cg15744005 chr10:104629667 AS3MT -0.34 -7.32 -0.37 1.9e-12 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs9463078 0.691 rs6938177 chr6:45271834 T/C cg25276700 chr6:44698697 NA -0.25 -6.0 -0.31 5.11e-9 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; CRC cis rs1799949 0.965 rs8176198 chr17:41230537 A/T cg05368731 chr17:41323189 NBR1 0.61 9.19 0.45 4.55e-18 Menopause (age at onset); CRC cis rs11098499 0.954 rs35063680 chr4:120387102 T/C cg24375607 chr4:120327624 NA 0.5 7.72 0.39 1.4e-13 Corneal astigmatism; CRC cis rs8078723 0.966 rs57065891 chr17:38168227 C/T cg17344932 chr17:38183730 MED24;SNORD124 -0.45 -7.01 -0.36 1.37e-11 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); CRC cis rs758324 0.947 rs58016983 chr5:131235275 T/C cg06307176 chr5:131281290 NA -0.41 -6.1 -0.32 3.02e-9 Alzheimer's disease in APOE e4- carriers; CRC cis rs13315871 1.000 rs13076951 chr3:58436703 C/T cg20936604 chr3:58311152 NA -0.72 -7.15 -0.37 5.58e-12 Cholesterol, total; CRC cis rs1129187 0.755 rs9471988 chr6:42944773 T/C cg02359409 chr6:42947317 PEX6 -0.69 -11.5 -0.54 5.82e-26 Alzheimer's disease in APOE e4+ carriers; CRC cis rs6694672 1.000 rs1888991 chr1:197110822 A/G cg13682187 chr1:196946512 CFHR5 0.47 7.27 0.37 2.67e-12 Asthma; CRC cis rs858239 0.669 rs10950940 chr7:23196816 C/T cg00469287 chr7:23338798 C7orf30 -0.43 -5.76 -0.3 1.91e-8 Cerebrospinal fluid biomarker levels; CRC trans rs1728785 0.901 rs1728797 chr16:68570989 A/T cg04657470 chr2:198365150 HSPE1;HSPD1 0.58 6.97 0.36 1.72e-11 Ulcerative colitis; CRC cis rs6546550 0.901 rs6754896 chr2:70138170 T/C cg02498382 chr2:70120550 SNRNP27 -0.56 -9.52 -0.46 3.78e-19 Prevalent atrial fibrillation; CRC cis rs4481887 1.000 rs10788781 chr1:248494262 C/T cg00666640 chr1:248458726 OR2T12 0.55 9.44 0.46 6.87e-19 Common traits (Other); CRC cis rs3731896 0.653 rs10932799 chr2:220200705 C/T cg00436969 chr2:220197716 RESP18 -0.46 -5.82 -0.31 1.42e-8 Educational attainment; CRC cis rs10089 1.000 rs2898096 chr5:127433214 C/T cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.76 10.79 0.51 1.99e-23 Ileal carcinoids; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg19069346 chr21:41239214 PCP4 0.44 6.79 0.35 5.29e-11 Liver disease severity in Alagille syndrome; CRC cis rs9911578 0.967 rs7222789 chr17:56819853 C/G cg05425664 chr17:57184151 TRIM37 -0.48 -7.6 -0.39 3.02e-13 Intelligence (multi-trait analysis); CRC cis rs7659604 0.702 rs6826506 chr4:122710865 T/G cg20573242 chr4:122745356 CCNA2 0.52 7.47 0.38 7.15e-13 Type 2 diabetes; CRC cis rs8180040 0.701 rs12491473 chr3:46989904 G/A cg10298567 chr3:47292165 KIF9 0.37 5.84 0.31 1.28e-8 Colorectal cancer; CRC cis rs10911232 0.507 rs10752888 chr1:182993751 A/G ch.1.3577855R chr1:183094577 LAMC1 0.86 15.15 0.64 1.1e-39 Hypertriglyceridemia; CRC trans rs4378999 0.660 rs11928733 chr3:50833438 C/T cg12383621 chr7:7735611 RPA3 -0.48 -6.1 -0.32 2.95e-9 Waist circumference adjusted for BMI in non-smokers;Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction); CRC cis rs2658782 1.000 rs2608216 chr11:93149172 G/A cg15737290 chr11:93063684 CCDC67 0.52 7.54 0.38 4.47e-13 Pulmonary function decline; CRC cis rs2408955 0.501 rs8716 chr12:48539482 T/G cg21466736 chr12:48725269 NA -0.49 -7.54 -0.38 4.68e-13 Glycated hemoglobin levels; CRC cis rs73200209 0.744 rs56869346 chr12:116514538 T/C cg01776926 chr12:116560359 MED13L -0.62 -7.25 -0.37 2.95e-12 Total body bone mineral density; CRC cis rs9733 0.596 rs72702585 chr1:150696427 G/A cg17724175 chr1:150552817 MCL1 0.57 9.12 0.45 7.76e-18 Tonsillectomy; CRC cis rs6693567 0.565 rs698917 chr1:150319884 G/A cg15654264 chr1:150340011 RPRD2 0.41 6.05 0.32 3.93e-9 Migraine; CRC cis rs2985684 1.000 rs7142457 chr14:50097862 C/T cg04989706 chr14:50066350 PPIL5 -0.49 -6.92 -0.36 2.32e-11 Carotid intima media thickness; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg13628960 chr20:62258574 GMEB2 0.42 5.96 0.31 6.39e-9 Anxiety disorder; CRC cis rs7107174 0.748 rs11237458 chr11:78050849 A/T cg02023728 chr11:77925099 USP35 0.5 8.91 0.44 3.47e-17 Testicular germ cell tumor; CRC cis rs7811142 1.000 rs73161762 chr7:100014846 C/T cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.59 7.33 0.37 1.83e-12 Platelet count; CRC cis rs3008870 0.755 rs2755243 chr1:67482783 T/C cg08660285 chr1:67390436 MIER1;WDR78 0.56 7.93 0.4 3.43e-14 Lymphocyte percentage of white cells; CRC cis rs7927771 1.000 rs12421210 chr11:47779586 C/T cg20307385 chr11:47447363 PSMC3 -0.5 -6.58 -0.34 1.83e-10 Subjective well-being; CRC cis rs554111 0.613 rs3816455 chr1:21191430 A/G cg02927042 chr1:21476669 EIF4G3 0.37 5.61 0.3 4.23e-8 Facial morphology (factor 17, height of vermillion upper lip); CRC cis rs372883 0.530 rs2832302 chr21:30749793 G/T cg08807101 chr21:30365312 RNF160 -0.47 -7.09 -0.36 8.08e-12 Pancreatic cancer; CRC cis rs7927771 0.929 rs12787646 chr11:47669665 T/C cg18512352 chr11:47633146 NA -0.45 -8.83 -0.44 6.35e-17 Subjective well-being; CRC cis rs2832191 0.692 rs2245517 chr21:30357968 C/T cg24692254 chr21:30365293 RNF160 0.86 16.13 0.66 1.5e-43 Dental caries; CRC cis rs12541335 0.639 rs6993855 chr8:22163797 A/G cg27266060 chr8:22091797 NA 0.35 5.86 0.31 1.11e-8 Hypertriglyceridemia; CRC cis rs3806843 0.576 rs246002 chr5:140341104 A/G cg19875535 chr5:140030758 IK 0.42 6.42 0.33 4.88e-10 Depressive symptoms (multi-trait analysis); CRC cis rs8044995 0.517 rs61593058 chr16:68384496 T/C cg09835421 chr16:68378352 PRMT7 -0.61 -7.55 -0.38 4.27e-13 Schizophrenia; CRC cis rs896854 0.654 rs6982393 chr8:95980708 T/C cg09323728 chr8:95962352 TP53INP1 -0.46 -7.58 -0.39 3.66e-13 Type 2 diabetes; CRC cis rs887829 0.570 rs12623271 chr2:234599941 C/G cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.45 -7.06 -0.36 9.85e-12 Metabolic traits;Bilirubin levels;Cholelithiasis-related traits in sickle cell anemia;Metabolite levels;Total bilirubin levels in HIV-1 infection;Serum metabolite levels;Blood metabolite levels; CRC cis rs11098499 0.954 rs71614438 chr4:120371252 G/A cg24375607 chr4:120327624 NA 0.51 7.98 0.4 2.49e-14 Corneal astigmatism; CRC trans rs67340775 0.541 rs200966 chr6:27862152 T/C cg06606381 chr12:133084897 FBRSL1 -0.6 -5.98 -0.31 5.93e-9 Lung cancer in ever smokers; CRC cis rs644799 1.000 rs2508289 chr11:95624669 A/G cg03916912 chr11:95522834 CEP57;FAM76B 0.95 17.78 0.7 4.72e-50 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs4689388 0.853 rs1079214 chr4:6282157 T/C cg00701064 chr4:6280414 WFS1 0.77 13.15 0.59 4.95e-32 Type 2 diabetes and other traits;Type 2 diabetes; CRC cis rs2243480 1.000 rs6460274 chr7:65628484 T/A cg25985355 chr7:65971099 NA 0.53 6.05 0.32 3.9e-9 Diabetic kidney disease; CRC cis rs2836974 0.897 rs36113648 chr21:40555497 G/A cg06238570 chr21:40685208 BRWD1 0.74 10.35 0.5 6.5600000000000005e-22 Cognitive function; CRC cis rs853679 0.517 rs9380058 chr6:28127444 T/C cg12273811 chr6:28175739 NA 0.72 9.03 0.45 1.47e-17 Depression; CRC cis rs8077889 0.956 rs58242860 chr17:41847300 T/C cg25876840 chr17:41920477 NA 0.44 6.42 0.33 4.88e-10 Triglycerides; CRC trans rs587242 1.000 rs12757257 chr1:96898302 G/A cg10631902 chr5:14652156 NA 0.44 6.84 0.35 3.84e-11 Body mass index (joint analysis main effects and physical activity interaction);Body mass index in physically inactive individuals;Body mass index; CRC cis rs12477438 0.784 rs13407840 chr2:99569928 C/T cg26064155 chr2:99771622 LIPT1;TSGA10 -0.62 -8.56 -0.43 4.41e-16 Chronic sinus infection; CRC cis rs34172651 0.517 rs1465423 chr16:24772680 C/G cg02428538 chr16:24856791 SLC5A11 0.56 6.68 0.35 1.02e-10 Intelligence (multi-trait analysis); CRC cis rs1005277 0.522 rs289643 chr10:37941494 T/G cg25427524 chr10:38739819 LOC399744 -0.68 -11.18 -0.52 8.4e-25 Extrinsic epigenetic age acceleration; CRC cis rs4664308 0.967 rs7563607 chr2:160910215 C/G cg03641300 chr2:160917029 PLA2R1 -0.75 -12.51 -0.57 1.18e-29 Idiopathic membranous nephropathy; CRC cis rs7553864 1.000 rs7515367 chr1:87615798 A/T cg02083836 chr1:87617350 LOC339524 0.36 6.34 0.33 7.65e-10 Smoking behavior; CRC trans rs10403021 0.855 rs10500240 chr19:30068492 A/C cg22044635 chr17:76557109 DNAH17 0.44 6.13 0.32 2.57e-9 Diabetic retinopathy; CRC cis rs10256972 0.713 rs10435026 chr7:1065948 A/G cg04025307 chr7:1156635 C7orf50 0.49 7.28 0.37 2.5e-12 Longevity;Endometriosis; CRC trans rs9914544 0.545 rs7212905 chr17:18774271 A/G cg21372672 chr17:16614065 CCDC144A -0.39 -6.15 -0.32 2.25e-9 Educational attainment (years of education); CRC cis rs4862750 0.957 rs2375916 chr4:187903923 A/G cg03647317 chr4:187891568 NA -0.56 -10.06 -0.49 6.05e-21 Lobe attachment (rater-scored or self-reported); CRC cis rs1348850 0.914 rs7591807 chr2:178252986 A/G cg02961200 chr2:178257176 LOC100130691;AGPS 0.61 9.16 0.45 5.79e-18 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs6835098 0.923 rs7671278 chr4:174095769 A/G cg08422745 chr4:174089978 GALNT7 -0.95 -15.01 -0.64 3.79e-39 Dementia and core Alzheimer's disease neuropathologic changes; CRC cis rs9300255 0.602 rs1727317 chr12:123618942 T/C cg00376283 chr12:123451042 ABCB9 0.61 7.3 0.37 2.12e-12 Neutrophil percentage of white cells; CRC cis rs3820068 0.581 rs1547033 chr1:15918988 T/C cg27534772 chr1:16042836 PLEKHM2 0.55 10.53 0.5 1.54e-22 Systolic blood pressure; CRC cis rs8072100 0.790 rs11079783 chr17:45686016 C/T cg08085267 chr17:45401833 C17orf57 0.55 8.36 0.42 1.85e-15 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs1018836 0.608 rs10111060 chr8:91491152 T/C cg16814680 chr8:91681699 NA -0.57 -8.47 -0.42 8.14e-16 Ejection fraction in Tripanosoma cruzi seropositivity; CRC cis rs9611565 0.659 rs9611610 chr22:41949259 A/G cg06481639 chr22:41940642 POLR3H -0.56 -6.34 -0.33 7.62e-10 Vitiligo; CRC cis rs60871478 1.000 rs67721251 chr7:825114 T/C cg04727924 chr7:799746 HEATR2 -0.39 -5.87 -0.31 1.04e-8 Cerebrospinal P-tau181p levels; CRC cis rs7113874 0.589 rs10840060 chr11:8500045 A/C cg02811074 chr11:8615871 STK33 0.38 6.43 0.33 4.54e-10 Body mass index in physically active individuals;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs1023500 0.573 rs6002592 chr22:42476754 A/C cg15557168 chr22:42548783 NA 0.38 6.43 0.33 4.54e-10 Schizophrenia; CRC cis rs2228479 1.000 rs117406136 chr16:89974605 C/T cg06558623 chr16:89946397 TCF25 1.08 10.77 0.51 2.34e-23 Skin colour saturation; CRC cis rs2404602 0.684 rs57682236 chr15:76868478 G/A cg03037974 chr15:76606532 NA -0.48 -6.98 -0.36 1.62e-11 Blood metabolite levels; CRC cis rs1799949 0.965 rs35521261 chr17:41313612 A/G cg01879757 chr17:41196368 BRCA1 -0.43 -6.59 -0.34 1.79e-10 Menopause (age at onset); CRC cis rs1799949 1.000 rs12952790 chr17:41299607 A/G cg05368731 chr17:41323189 NBR1 0.69 10.5 0.5 1.94e-22 Menopause (age at onset); CRC trans rs2898290 0.500 rs11998678 chr8:11830150 A/G cg16141378 chr3:129829833 LOC729375 0.48 6.89 0.36 2.78e-11 Systolic blood pressure; CRC cis rs7615952 0.558 rs17334039 chr3:125540308 A/G cg05084668 chr3:125655381 ALG1L -0.42 -5.94 -0.31 7.23e-9 Blood pressure (smoking interaction); CRC cis rs12824058 0.831 rs12320318 chr12:130812335 T/C cg26677194 chr12:130822605 PIWIL1 0.45 7.18 0.37 4.53e-12 Menopause (age at onset); CRC cis rs6712932 1.000 rs6746579 chr2:105843223 G/T cg22878388 chr2:105853796 NA -0.32 -6.25 -0.33 1.27e-9 Type 2 diabetes; CRC cis rs3858526 0.584 rs10734559 chr11:5861788 A/C cg02574844 chr11:5959923 NA -0.49 -7.11 -0.36 7.26e-12 DNA methylation (variation); CRC trans rs11031096 0.702 rs2735691 chr11:4117709 C/G cg22978087 chr8:24814126 NEFL 0.32 6.01 0.31 4.86e-9 Mean corpuscular volume;Mean corpuscular hemoglobin; CRC trans rs11165623 0.564 rs6669908 chr1:96998261 G/A cg10631902 chr5:14652156 NA -0.4 -6.83 -0.35 4.13e-11 Hip circumference;Waist circumference; CRC cis rs853679 0.517 rs17774663 chr6:28120898 G/A cg03623178 chr6:28175578 NA 0.98 12.66 0.57 3.31e-30 Depression; CRC cis rs2952156 1.000 rs1810132 chr17:37866005 C/T cg00129232 chr17:37814104 STARD3 -0.67 -10.82 -0.51 1.46e-23 Asthma; CRC trans rs10060123 1.000 rs10057227 chr5:125685374 A/G ch.6.113866684R chr6:113759991 NA -0.38 -5.97 -0.31 6.31e-9 Visceral adipose tissue adjusted for BMI;Visceral adipose tissue; CRC cis rs1878931 0.582 rs9937267 chr16:3421073 C/T cg02880119 chr16:3481970 NA -0.41 -5.8 -0.3 1.55e-8 Body mass index (adult); CRC cis rs3741404 0.791 rs7102177 chr11:63909228 T/C cg19465662 chr11:63993652 NUDT22;TRPT1 0.85 13.85 0.61 1.09e-34 Platelet count; CRC cis rs4689388 0.926 rs11725500 chr4:6293919 C/G cg00701064 chr4:6280414 WFS1 0.75 13.24 0.59 2.32e-32 Type 2 diabetes and other traits;Type 2 diabetes; CRC cis rs1387259 0.859 rs2054905 chr12:48687951 A/G cg21466736 chr12:48725269 NA -0.55 -8.25 -0.41 3.86e-15 Obstructive sleep apnea trait (apnea hypopnea index); CRC cis rs60871478 0.545 rs35400476 chr7:795686 A/G cg05535760 chr7:792225 HEATR2 0.78 10.15 0.49 3.14e-21 Cerebrospinal P-tau181p levels; CRC trans rs6550704 0.687 rs9865314 chr3:22634337 A/G cg16442050 chr2:27294098 LOC100128731 -0.43 -6.49 -0.34 3.19e-10 Daytime sleep phenotypes; CRC cis rs2929278 0.589 rs7174732 chr15:44038463 C/A cg02155558 chr15:43621948 ADAL;LCMT2 -0.43 -5.82 -0.31 1.4e-8 Schizophrenia; CRC cis rs10927875 0.541 rs1048245 chr1:16341354 T/G cg10494257 chr1:16342123 HSPB7 0.45 6.23 0.32 1.41e-9 Dilated cardiomyopathy; CRC cis rs6951245 0.872 rs76713558 chr7:1095866 A/G cg22907277 chr7:1156413 C7orf50 0.72 7.6 0.39 3.1400000000000003e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs10078 0.571 rs2721014 chr5:463539 G/A cg08916839 chr5:415575 AHRR 0.83 8.43 0.42 1.11e-15 Fat distribution (HIV); CRC cis rs7224737 1.000 rs7214921 chr17:40294025 T/C cg00647820 chr17:40259828 DHX58 -0.46 -6.5 -0.34 3.04e-10 Fibrinogen levels; CRC cis rs6701037 0.681 rs13374887 chr1:175131962 A/T cg00321850 chr1:175162397 KIAA0040 0.4 6.68 0.35 1.01e-10 Alcohol dependence; CRC cis rs1383484 0.640 rs12101685 chr15:84643657 A/G cg11189052 chr15:85197271 WDR73 -0.46 -5.82 -0.31 1.42e-8 Height; CRC cis rs3540 0.920 rs7182658 chr15:91019248 A/T cg22089800 chr15:90895588 ZNF774 0.49 7.79 0.39 9.01e-14 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; CRC cis rs7208859 0.673 rs73265612 chr17:29225983 A/G cg01831904 chr17:28903510 LRRC37B2 -0.56 -5.83 -0.31 1.35e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs28386778 0.897 rs894413 chr17:61916347 A/G cg06873352 chr17:61820015 STRADA 0.76 14.12 0.61 1.01e-35 Prudent dietary pattern; CRC cis rs10883723 0.738 rs715438 chr10:104258303 C/T cg11453585 chr10:104263688 ACTR1A;SUFU 0.9 16.72 0.68 7.16e-46 Allergic disease (asthma, hay fever or eczema); CRC cis rs17376456 0.825 rs35496867 chr5:93220400 T/C cg25358565 chr5:93447407 FAM172A 1.06 10.38 0.5 5.21e-22 Diabetic retinopathy; CRC trans rs1005277 0.579 rs2474575 chr10:38387901 C/T cg27523141 chr10:43048294 ZNF37B 0.49 7.21 0.37 3.88e-12 Extrinsic epigenetic age acceleration; CRC cis rs883565 0.543 rs784496 chr3:39179536 A/G cg01426195 chr3:39028469 NA 0.41 6.68 0.35 1.03e-10 Handedness; CRC cis rs10504229 1.000 rs56740825 chr8:58175617 A/G cg05313129 chr8:58192883 C8orf71 -0.47 -6.99 -0.36 1.49e-11 Developmental language disorder (linguistic errors); CRC cis rs539096 0.500 rs803678 chr1:44350898 G/T cg13606994 chr1:44402422 ARTN -0.34 -5.73 -0.3 2.23e-8 Intelligence (multi-trait analysis); CRC trans rs2303319 0.504 rs62189055 chr2:162625749 C/A cg01919652 chr6:150259930 NA -0.69 -5.99 -0.31 5.48e-9 Cognitive function; CRC cis rs1862618 0.853 rs9283717 chr5:56078659 G/A cg24531977 chr5:56204891 C5orf35 -0.85 -11.3 -0.53 3.17e-25 Initial pursuit acceleration; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg20505218 chr17:80009845 GPS1;RFNG 0.47 6.63 0.34 1.4e-10 Response to antipsychotic treatment; CRC cis rs7186908 1.000 rs7186908 chr16:72220373 G/C cg23815491 chr16:72088622 HP 0.52 6.35 0.33 7.24e-10 Liver enzyme levels (alkaline phosphatase); CRC cis rs519973 1.000 rs491087 chr3:187636166 G/A cg10168494 chr3:187635183 NA 0.51 8.92 0.44 3.42e-17 Allergic disease (asthma, hay fever or eczema); CRC cis rs7777754 0.512 rs4470989 chr7:50562698 T/A cg18232548 chr7:50535776 DDC -0.45 -6.87 -0.35 3.15e-11 Response to zileuton treatment in asthma (FEV1 change interaction); CRC trans rs1005277 0.522 rs289643 chr10:37941494 T/G cg17830980 chr10:43048298 ZNF37B -0.41 -6.24 -0.33 1.38e-9 Extrinsic epigenetic age acceleration; CRC cis rs4803468 0.967 rs892044 chr19:41903671 A/G cg09537434 chr19:41945824 ATP5SL -0.93 -18.3 -0.71 4.44e-52 Height; CRC cis rs9640161 0.789 rs28432021 chr7:150046235 G/C cg27494647 chr7:150038898 RARRES2 0.36 5.63 0.3 3.97e-8 Blood protein levels;Circulating chemerin levels; CRC cis rs1348850 0.668 rs2365619 chr2:178497366 A/G cg27490568 chr2:178487706 NA -0.45 -6.26 -0.33 1.23e-9 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs6502050 0.835 rs4789672 chr17:80126603 T/C cg25804541 chr17:80189381 SLC16A3 -0.31 -5.95 -0.31 6.89e-9 Life satisfaction; CRC cis rs9902453 0.817 rs12051834 chr17:28192785 C/T cg26525008 chr17:28256777 EFCAB5;SSH2 0.57 8.69 0.43 1.78e-16 Coffee consumption (cups per day); CRC cis rs1799949 0.965 rs799917 chr17:41244936 G/A cg05368731 chr17:41323189 NBR1 0.58 8.7 0.43 1.59e-16 Menopause (age at onset); CRC cis rs3741404 0.560 rs7938819 chr11:63910116 G/A cg06243084 chr11:63990629 FERMT3 0.4 6.19 0.32 1.79e-9 Platelet count; CRC cis rs801193 1.000 rs2707836 chr7:66160435 A/C cg05627663 chr7:65219948 SNORA22;CCT6P1 0.43 6.27 0.33 1.13e-9 Aortic root size; CRC cis rs1552244 0.766 rs34232505 chr3:10186216 T/A cg00166722 chr3:10149974 C3orf24 0.65 8.51 0.42 6.38e-16 Alzheimer's disease; CRC trans rs2727020 0.521 rs4980445 chr11:49570183 C/T cg03929089 chr4:120376271 NA -0.76 -10.48 -0.5 2.25e-22 Coronary artery disease; CRC cis rs919433 0.680 rs3792160 chr2:198403519 G/A cg10820045 chr2:198174542 NA 0.4 6.87 0.35 3.26e-11 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC cis rs10256972 0.591 rs6968988 chr7:1169619 A/G cg16145915 chr7:1198662 ZFAND2A -0.45 -9.17 -0.45 5.24e-18 Longevity;Endometriosis; CRC cis rs1223397 0.589 rs2439540 chr6:13309342 G/A cg20827128 chr6:13274284 PHACTR1 0.4 6.08 0.32 3.34e-9 Blood pressure; CRC cis rs4728302 0.869 rs7792492 chr7:133595316 C/T cg03336402 chr7:133662267 EXOC4 -0.42 -6.36 -0.33 6.83e-10 Intelligence;Intelligence (multi-trait analysis); CRC cis rs950776 0.593 rs621849 chr15:78872861 G/A cg06917634 chr15:78832804 PSMA4 -0.57 -8.81 -0.44 7.42e-17 Sudden cardiac arrest; CRC cis rs1862618 0.671 rs2591965 chr5:56236176 T/C cg18230493 chr5:56204884 C5orf35 0.59 8.59 0.43 3.5e-16 Initial pursuit acceleration; CRC cis rs3749237 0.964 rs35210174 chr3:49812606 C/T cg05072774 chr3:49840536 C3orf54 -0.43 -5.74 -0.3 2.15e-8 Resting heart rate; CRC cis rs8060686 0.920 rs73594556 chr16:67925435 G/A cg19582491 chr16:67682965 RLTPR -0.58 -6.91 -0.36 2.5e-11 HDL cholesterol;Metabolic syndrome; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg01622965 chr7:98476371 TRRAP 0.5 6.48 0.34 3.42e-10 Thyroid stimulating hormone; CRC cis rs9549260 0.816 rs7334318 chr13:41217410 C/G cg21288729 chr13:41239152 FOXO1 0.49 7.66 0.39 2.08e-13 Red blood cell count; CRC cis rs4919694 1.000 rs4919694 chr10:104698978 T/C cg04362960 chr10:104952993 NT5C2 1.06 10.05 0.48 6.51e-21 Arsenic metabolism; CRC trans rs7726839 0.507 rs60068988 chr5:597668 T/C cg11887960 chr12:57824829 NA 0.59 6.66 0.34 1.15e-10 Obesity-related traits; CRC cis rs7584330 0.518 rs74478860 chr2:238437364 C/G cg14458575 chr2:238380390 NA 0.8 10.05 0.48 6.61e-21 Prostate cancer; CRC cis rs9649213 0.593 rs12704982 chr7:97926053 C/T cg24562669 chr7:97807699 LMTK2 0.42 7.01 0.36 1.39e-11 Prostate cancer (SNP x SNP interaction); CRC cis rs2204008 0.744 rs8189486 chr12:38244968 C/T cg13010199 chr12:38710504 ALG10B 0.45 5.75 0.3 2.07e-8 Bladder cancer; CRC cis rs9928842 0.823 rs4888365 chr16:75282247 A/G cg09066997 chr16:75300724 BCAR1 0.65 6.17 0.32 2e-9 Alcoholic chronic pancreatitis; CRC cis rs597539 0.652 rs553875 chr11:68695144 T/G cg04772025 chr11:68637568 NA 0.48 7.22 0.37 3.63e-12 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs10504229 0.595 rs76447299 chr8:58117395 A/G cg24829409 chr8:58192753 C8orf71 -0.55 -8.03 -0.4 1.71e-14 Developmental language disorder (linguistic errors); CRC cis rs6502050 0.871 rs8080366 chr17:80067298 A/G cg22110888 chr17:80059540 CCDC57 -0.42 -6.41 -0.33 5.19e-10 Life satisfaction; CRC cis rs13217239 0.646 rs4269366 chr6:27016413 C/T cg12292205 chr6:26970375 C6orf41 0.52 8.5 0.42 6.7e-16 Schizophrenia; CRC cis rs2580764 0.678 rs2588521 chr2:55203931 C/G cg09592903 chr2:55203963 RTN4 0.76 12.16 0.56 2.3e-28 Mean platelet volume; CRC cis rs734999 0.566 rs4648563 chr1:2536002 C/G cg18854424 chr1:2615690 NA 0.4 7.74 0.39 1.22e-13 Ulcerative colitis; CRC cis rs6546550 0.935 rs1377995 chr2:70064155 C/G cg02498382 chr2:70120550 SNRNP27 -0.47 -7.72 -0.39 1.39e-13 Prevalent atrial fibrillation; CRC cis rs57502260 0.573 rs12291008 chr11:68389072 T/C cg16797656 chr11:68205561 LRP5 0.48 6.82 0.35 4.36e-11 Total body bone mineral density (age 45-60); CRC cis rs6952808 0.729 rs35797753 chr7:1954914 G/A cg04267008 chr7:1944627 MAD1L1 -0.82 -12.41 -0.56 2.91e-29 Bipolar disorder and schizophrenia; CRC cis rs524281 0.861 rs10896077 chr11:65851733 C/G cg14036092 chr11:66035641 RAB1B -0.47 -5.78 -0.3 1.76e-8 Electroencephalogram traits; CRC cis rs2213920 0.679 rs7862261 chr9:118187677 A/G cg13918206 chr9:118159781 DEC1 0.62 5.96 0.31 6.67e-9 Docetaxel-induced peripheral neuropathy in metastatic castrate-resistant prostate cancer; CRC cis rs745570 1.000 rs745571 chr17:77781387 T/C cg04986373 chr17:77768687 CBX8 0.44 6.58 0.34 1.83e-10 Breast cancer; CRC trans rs7615952 0.641 rs60839048 chr3:125807938 G/A cg07211511 chr3:129823064 LOC729375 -0.71 -9.4 -0.46 9.34e-19 Blood pressure (smoking interaction); CRC cis rs9611565 0.512 rs9611672 chr22:42209922 A/G cg06634786 chr22:41940651 POLR3H -0.7 -7.83 -0.4 6.73e-14 Vitiligo; CRC cis rs10911363 0.592 rs2702178 chr1:183452545 G/A cg09173681 chr1:183549694 NCF2 0.73 10.13 0.49 3.49e-21 Systemic lupus erythematosus; CRC cis rs9322193 0.923 rs9689084 chr6:149960784 G/A cg07701084 chr6:150067640 NUP43 0.53 7.76 0.39 1.09e-13 Lung cancer; CRC cis rs6500395 0.775 rs1968903 chr16:48664014 C/T cg04672837 chr16:48644449 N4BP1 0.44 6.53 0.34 2.53e-10 Response to tocilizumab in rheumatoid arthritis; CRC cis rs10504229 0.953 rs17805380 chr8:58171128 C/A cg24829409 chr8:58192753 C8orf71 -0.68 -11.34 -0.53 2.27e-25 Developmental language disorder (linguistic errors); CRC cis rs873946 0.618 rs12775767 chr10:134545628 C/T cg18305652 chr10:134549665 INPP5A 0.48 6.11 0.32 2.83e-9 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CRC cis rs1799949 1.000 rs8176077 chr17:41276348 T/C cg19454999 chr17:41278357 BRCA1;NBR2 0.55 8.63 0.43 2.68e-16 Menopause (age at onset); CRC cis rs514406 0.825 rs6588441 chr1:53223494 G/A cg27535305 chr1:53392650 SCP2 0.38 6.97 0.36 1.77e-11 Monocyte count; CRC trans rs1728785 1.000 rs1170431 chr16:68605639 T/C cg04657470 chr2:198365150 HSPE1;HSPD1 0.59 7.14 0.37 6.11e-12 Ulcerative colitis; CRC cis rs9522267 0.535 rs9515453 chr13:112234612 T/C cg26182253 chr13:112236782 NA 0.31 6.3 0.33 9.74e-10 Hepatitis; CRC cis rs992157 0.835 rs10932769 chr2:219147245 T/G cg04731861 chr2:219085781 ARPC2 0.33 6.93 0.36 2.21e-11 Colorectal cancer; CRC cis rs7542091 0.669 rs7540534 chr1:210044824 A/T cg22029157 chr1:209979665 IRF6 0.47 7.4 0.38 1.11e-12 Monobrow; CRC cis rs9322193 0.962 rs6903998 chr6:150152493 T/C cg07701084 chr6:150067640 NUP43 0.46 6.49 0.34 3.22e-10 Lung cancer; CRC cis rs7727544 0.735 rs274566 chr5:131715011 A/G cg24060327 chr5:131705240 SLC22A5 0.36 5.9 0.31 8.97e-9 Blood metabolite levels; CRC cis rs473651 0.837 rs563458 chr2:239345613 T/A cg21699342 chr2:239360505 ASB1 0.58 10.48 0.5 2.38e-22 Multiple system atrophy; CRC cis rs12760731 0.720 rs12072124 chr1:178366990 G/A cg00404053 chr1:178313656 RASAL2 0.9 10.11 0.49 4.33e-21 Obesity-related traits; CRC cis rs6866344 0.570 rs1132336 chr5:178140090 C/T cg03877680 chr5:178157825 ZNF354A 0.77 11.07 0.52 2.09e-24 Neutrophil percentage of white cells; CRC cis rs6499255 0.951 rs9788837 chr16:69688413 A/G cg15192750 chr16:69999425 NA 0.59 7.96 0.4 2.79e-14 IgE levels; CRC cis rs9811920 0.638 rs793474 chr3:99544380 C/T cg07805332 chr3:99536008 MIR548G;C3orf26 -0.52 -7.88 -0.4 4.83e-14 Axial length; CRC cis rs6942756 0.806 rs1880854 chr7:128949748 G/T cg02491457 chr7:128862824 NA 0.66 9.18 0.45 4.89e-18 White matter hyperintensity burden; CRC cis rs2404602 0.692 rs35077207 chr15:76935306 A/G cg03037974 chr15:76606532 NA 0.72 12.72 0.57 1.97e-30 Blood metabolite levels; CRC cis rs875971 0.660 rs801211 chr7:66015689 T/G cg11764359 chr7:65958608 NA -0.55 -8.6 -0.43 3.21e-16 Aortic root size; CRC cis rs13108904 0.967 rs62293658 chr4:1276416 T/C cg20092199 chr4:1342459 KIAA1530 -0.41 -7.71 -0.39 1.48e-13 Obesity-related traits; CRC trans rs6601327 0.700 rs12114661 chr8:9573154 G/A cg06636001 chr8:8085503 FLJ10661 -0.51 -7.42 -0.38 1.03e-12 Multiple myeloma (hyperdiploidy); CRC cis rs736408 0.609 rs13087772 chr3:52782274 T/G cg11645453 chr3:52864694 ITIH4 0.36 6.27 0.33 1.14e-9 Bipolar disorder; CRC cis rs7618915 0.570 rs4687633 chr3:52630548 G/A cg05573699 chr3:52720067 GNL3;PBRM1 -0.46 -6.57 -0.34 2.01e-10 Bipolar disorder; CRC cis rs67340775 0.541 rs200975 chr6:27855625 G/T cg26587870 chr6:27730563 NA -0.56 -6.44 -0.33 4.31e-10 Lung cancer in ever smokers; CRC cis rs10751667 0.643 rs7942693 chr11:957832 G/A ch.11.42038R chr11:967971 AP2A2 0.57 9.99 0.48 1.07e-20 Alzheimer's disease (late onset); CRC cis rs7762018 0.607 rs77004024 chr6:170063437 G/A cg19338460 chr6:170058176 WDR27 -1.25 -11.45 -0.53 9.22e-26 Thiazide-induced adverse metabolic effects in hypertensive patients; CRC cis rs10982256 0.935 rs1555700 chr9:117256375 T/C cg13636371 chr9:117264095 DFNB31 0.39 7.5 0.38 5.88e-13 Bipolar disorder; CRC cis rs10782582 0.609 rs72979226 chr1:76302222 C/A cg03433033 chr1:76189801 ACADM -0.41 -5.85 -0.31 1.17e-8 Daytime sleep phenotypes; CRC cis rs4713118 0.586 rs9468290 chr6:28087674 C/T cg02683197 chr6:28174875 NA 0.85 10.27 0.49 1.16e-21 Parkinson's disease; CRC cis rs7772486 0.790 rs2265469 chr6:146219049 T/C cg23711669 chr6:146136114 FBXO30 0.71 12.63 0.57 4.28e-30 Lobe attachment (rater-scored or self-reported); CRC cis rs9462846 0.959 rs7750915 chr6:42882067 C/T cg10862848 chr6:42927986 GNMT -0.31 -5.84 -0.31 1.27e-8 Blood protein levels; CRC cis rs1552244 0.515 rs7613004 chr3:9999913 A/C cg00166722 chr3:10149974 C3orf24 0.42 6.26 0.33 1.22e-9 Alzheimer's disease; CRC trans rs11098499 0.955 rs7685268 chr4:120162188 G/A cg25214090 chr10:38739885 LOC399744 0.52 8.02 0.4 1.94e-14 Corneal astigmatism; CRC cis rs853679 0.517 rs9393897 chr6:28127710 G/T cg15845792 chr6:28175446 NA 1.04 13.89 0.61 7.67e-35 Depression; CRC cis rs7119 0.717 rs11636412 chr15:77767291 C/T cg05673287 chr15:77411982 SGK269 -0.54 -8.18 -0.41 6.41e-15 Type 2 diabetes; CRC cis rs10504229 1.000 rs59071610 chr8:58186301 A/C cg05313129 chr8:58192883 C8orf71 -0.46 -6.86 -0.35 3.48e-11 Developmental language disorder (linguistic errors); CRC cis rs16882447 0.607 rs10052279 chr5:53491197 A/G cg06461071 chr5:53490839 ARL15 0.35 5.64 0.3 3.66e-8 Systolic blood pressure (dietary potassium intake interaction); CRC cis rs1552244 0.744 rs6763366 chr3:10033544 T/C cg16606324 chr3:10149918 C3orf24 0.62 8.08 0.41 1.25e-14 Alzheimer's disease; CRC cis rs727563 0.635 rs5751149 chr22:42139501 A/G cg03806693 chr22:41940476 POLR3H 1.08 13.41 0.59 5.35e-33 Crohn's disease;Inflammatory bowel disease; CRC cis rs758324 0.947 rs7725924 chr5:131118165 C/G cg06307176 chr5:131281290 NA 0.43 6.38 0.33 6.19e-10 Alzheimer's disease in APOE e4- carriers; CRC cis rs1401999 0.690 rs3805112 chr3:183645662 C/T cg01324343 chr3:183735012 ABCC5 0.62 9.93 0.48 1.74e-20 Anterior chamber depth; CRC cis rs832540 0.629 rs6888317 chr5:56093307 A/G cg18230493 chr5:56204884 C5orf35 0.4 5.83 0.31 1.29e-8 Coronary artery disease; CRC cis rs6838801 0.892 rs13108785 chr4:77576070 A/C cg17476223 chr4:77663285 SHROOM3 0.42 5.9 0.31 9.22e-9 Cleft lip with or without cleft palate; CRC cis rs12477438 0.520 rs34252185 chr2:99737646 A/G cg14399236 chr2:99771627 LIPT1;TSGA10 0.83 14.67 0.63 7.94e-38 Chronic sinus infection; CRC cis rs7894051 1.000 rs7899476 chr10:135197214 A/G cg24905316 chr10:135186343 ECHS1 0.72 6.42 0.33 4.89e-10 Lifespan; CRC cis rs6456156 0.774 rs2022001 chr6:167529509 C/T cg19688584 chr6:167529678 CCR6 -0.35 -6.39 -0.33 5.68e-10 Primary biliary cholangitis; CRC cis rs4665809 0.590 rs7582341 chr2:26416301 A/G cg22920501 chr2:26401640 FAM59B -0.82 -11.68 -0.54 1.37e-26 Gut microbiome composition (summer); CRC cis rs13191362 1.000 rs67094146 chr6:163145412 G/C cg21926612 chr6:163149169 PACRG;PARK2 0.86 12.24 0.56 1.2e-28 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs875971 0.964 rs778723 chr7:65829497 T/C cg18876405 chr7:65276391 NA 0.52 9.04 0.45 1.37e-17 Aortic root size; CRC cis rs362272 0.524 rs3129334 chr4:3368526 T/C cg01612440 chr4:3296283 NA 0.44 6.24 0.33 1.36e-9 Serum sulfate level; CRC cis rs2108622 0.647 rs111427692 chr19:15977479 A/T cg13772218 chr19:15982569 NA 0.47 6.59 0.34 1.74e-10 Circulating phylloquinone levels;Vitamin E levels;Acenocoumarol maintenance dosage;Response to Vitamin E supplementation;Metabolite levels;Warfarin maintenance dose; CRC cis rs523522 0.962 rs10849753 chr12:120910813 C/T cg12219531 chr12:120966889 COQ5 0.71 9.34 0.46 1.55e-18 High light scatter reticulocyte count; CRC cis rs2842992 0.789 rs2342446 chr6:160220687 A/G cg11366901 chr6:160182831 ACAT2 0.97 13.91 0.61 6.76e-35 Age-related macular degeneration (geographic atrophy); CRC trans rs1814175 0.645 rs10839456 chr11:49964093 C/T cg03929089 chr4:120376271 NA -0.9 -15.53 -0.65 3.38e-41 Height; CRC cis rs2276314 0.857 rs56230698 chr18:33628885 A/G cg19628046 chr18:33552617 C18orf21 0.56 7.75 0.39 1.19e-13 Endometriosis;Drug-induced torsades de pointes; CRC cis rs589448 0.902 rs315138 chr12:69764850 A/T cg14784868 chr12:69753453 YEATS4 0.91 17.67 0.7 1.31e-49 Cerebrospinal fluid biomarker levels; CRC cis rs11098499 0.874 rs6832670 chr4:120118792 A/G cg09307838 chr4:120376055 NA 0.61 8.95 0.44 2.69e-17 Corneal astigmatism; CRC cis rs2180341 0.855 rs4308584 chr6:127714874 A/G cg27446573 chr6:127587934 RNF146 0.7 9.62 0.47 1.84e-19 Breast cancer; CRC cis rs853679 0.760 rs9357067 chr6:28210293 C/G cg12273811 chr6:28175739 NA 0.55 5.86 0.31 1.12e-8 Depression; CRC cis rs3026101 0.671 rs748486 chr17:5290824 C/A cg25236894 chr17:5323110 RPAIN;NUP88 0.42 6.84 0.35 3.98e-11 Body mass index; CRC cis rs3858526 0.874 rs10838879 chr11:5950169 C/T cg26762873 chr11:5879799 OR52E8 -0.4 -5.88 -0.31 1.01e-8 DNA methylation (variation); CRC trans rs9409565 0.821 rs7858082 chr9:97063929 T/A cg05679027 chr9:99775184 HIATL2 0.41 6.1 0.32 3.04e-9 Colorectal cancer (alcohol consumption interaction); CRC cis rs7072216 0.770 rs942810 chr10:100167860 G/C cg26618903 chr10:100175079 PYROXD2 -0.42 -7.08 -0.36 8.9e-12 Metabolite levels; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg02888146 chr6:143267449 HIVEP2 0.43 6.03 0.32 4.41e-9 Intelligence (multi-trait analysis); CRC cis rs7589342 0.862 rs6745887 chr2:106468039 G/A cg16077055 chr2:106428750 NCK2 0.4 5.6 0.3 4.48e-8 Addiction; CRC cis rs7618501 0.602 rs2071206 chr3:50160109 G/A cg05623727 chr3:50126028 RBM5 -0.43 -7.32 -0.37 1.87e-12 Intelligence (multi-trait analysis); CRC cis rs4803455 0.565 rs1800470 chr19:41858921 G/A cg09537434 chr19:41945824 ATP5SL -0.57 -8.46 -0.42 9.09e-16 Migraine;Coronary artery disease; CRC cis rs7591163 0.959 rs10933217 chr2:228716226 T/C cg01216370 chr2:228736459 WDR69 -0.45 -5.72 -0.3 2.36e-8 Blood pressure; CRC trans rs2228479 0.717 rs17233678 chr16:89809962 T/C cg21302420 chr1:112162376 RAP1A 0.72 5.96 0.31 6.38e-9 Skin colour saturation; CRC cis rs8017423 0.605 rs3742673 chr14:90735707 C/T cg14092571 chr14:90743983 NA -0.49 -7.59 -0.39 3.38e-13 Mortality in heart failure; CRC cis rs853679 0.517 rs9348793 chr6:28084189 G/A cg18032046 chr6:28092343 ZSCAN16 -0.52 -6.02 -0.31 4.76e-9 Depression; CRC cis rs12188164 0.610 rs57433159 chr5:418725 C/T cg17553881 chr5:443987 EXOC3;C5orf55 -0.34 -7.15 -0.37 5.72e-12 Cystic fibrosis severity; CRC cis rs7107174 0.681 rs881337 chr11:78128335 G/C cg02023728 chr11:77925099 USP35 0.39 6.05 0.32 3.83e-9 Testicular germ cell tumor; CRC cis rs853679 0.517 rs67878650 chr6:28142587 G/C cg02631126 chr6:28058918 ZSCAN12L1 0.29 5.73 0.3 2.26e-8 Depression; CRC cis rs6952808 0.792 rs2056478 chr7:1953897 C/T cg21782813 chr7:2030301 MAD1L1 0.45 7.44 0.38 8.78e-13 Bipolar disorder and schizophrenia; CRC cis rs2629540 0.824 rs10901809 chr10:126410804 C/T cg08799069 chr10:126477246 METTL10 0.57 7.6 0.39 3.05e-13 Cocaine dependence; CRC cis rs473651 0.935 rs483166 chr2:239346641 C/T cg21699342 chr2:239360505 ASB1 -0.6 -10.82 -0.51 1.5e-23 Multiple system atrophy; CRC cis rs2153535 0.580 rs9378554 chr6:8488468 C/T cg07606381 chr6:8435919 SLC35B3 0.68 10.89 0.51 8.84e-24 Motion sickness; CRC cis rs763121 0.819 rs5757133 chr22:38947835 A/G cg06022373 chr22:39101656 GTPBP1 -0.69 -10.64 -0.51 6.51e-23 Menopause (age at onset); CRC cis rs28386778 0.897 rs894408 chr17:61896814 C/T cg23090583 chr17:61904693 PSMC5;FTSJ3 1.05 20.68 0.75 1.83e-61 Prudent dietary pattern; CRC cis rs12476592 0.602 rs262524 chr2:63892727 A/G cg10828910 chr2:63850056 LOC388955 0.51 6.44 0.33 4.22e-10 Childhood ear infection; CRC cis rs6586163 0.872 rs7910660 chr10:90743197 G/A cg03111039 chr10:90751583 FAS;ACTA2 -0.5 -7.08 -0.36 8.67e-12 Chronic lymphocytic leukemia; CRC cis rs11997175 0.549 rs4357253 chr8:33652458 G/A cg04338863 chr8:33670619 NA 0.39 6.73 0.35 7.52e-11 Body mass index; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg22728371 chr5:32313149 MTMR12 0.4 6.18 0.32 1.95e-9 Liver disease severity in Alagille syndrome; CRC cis rs763014 0.966 rs12935215 chr16:670605 T/C cg07343612 chr16:622815 PIGQ -0.81 -13.71 -0.6 3.61e-34 Height; CRC cis rs3814231 0.531 rs12773054 chr10:115476042 C/T cg24846397 chr10:115438155 CASP7 -0.34 -5.67 -0.3 3.17e-8 Vitiligo; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg00497091 chr1:145438415 TXNIP 0.44 6.05 0.32 3.87e-9 Response to antipsychotic treatment; CRC cis rs78456975 1.000 rs6712176 chr2:1556393 C/T cg12573674 chr2:1569213 NA -0.75 -7.87 -0.4 5.22e-14 Placebo response in major depressive disorder (% change in symptom score); CRC cis rs2242663 0.798 rs1791679 chr11:66337874 C/A cg24851651 chr11:66362959 CCS 0.44 7.22 0.37 3.67e-12 Bipolar disorder; CRC cis rs728616 0.867 rs79904324 chr10:81804688 A/G cg11900509 chr10:81946545 ANXA11 -0.57 -6.19 -0.32 1.77e-9 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs11252926 0.574 rs7068976 chr10:453112 A/G cg16386425 chr10:429943 DIP2C -0.43 -6.51 -0.34 2.87e-10 Psychosis in Alzheimer's disease; CRC cis rs2949837 0.581 rs1542819 chr7:45978059 T/C cg15898840 chr7:45960834 IGFBP3 0.45 7.4 0.38 1.12e-12 Sitting height ratio; CRC cis rs4727027 0.754 rs917124 chr7:148851213 C/T cg12479418 chr7:148823350 ZNF425;ZNF398 0.45 5.86 0.31 1.15e-8 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC cis rs344364 0.511 rs62040569 chr16:1948137 C/T cg14074117 chr16:1909714 C16orf73 0.41 5.66 0.3 3.28e-8 Glomerular filtration rate in chronic kidney disease; CRC cis rs7312933 1.000 rs3229 chr12:42475888 G/A cg17420585 chr12:42539391 GXYLT1 -0.43 -6.2 -0.32 1.68e-9 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CRC trans rs6867032 0.874 rs4975786 chr5:2004724 T/C cg24172324 chr2:232258363 NA -0.38 -5.97 -0.31 6.2e-9 Gut microbiome composition (winter); CRC cis rs10504229 0.906 rs73607868 chr8:58172482 T/C cg05313129 chr8:58192883 C8orf71 -0.47 -6.99 -0.36 1.49e-11 Developmental language disorder (linguistic errors); CRC cis rs17209837 0.607 rs7793196 chr7:87122847 A/G cg00919237 chr7:87102261 ABCB4 -0.52 -6.62 -0.34 1.42e-10 Gallbladder cancer; CRC cis rs1552244 0.572 rs3843008 chr3:10173742 C/T cg18598329 chr3:10140678 FANCD2;C3orf24 -0.84 -8.54 -0.43 5.17e-16 Alzheimer's disease; CRC cis rs7312774 0.748 rs10492214 chr12:107294758 T/C cg16260113 chr12:107380972 MTERFD3 0.74 7.55 0.38 4.46e-13 Severe influenza A (H1N1) infection; CRC cis rs11148252 0.811 rs9536030 chr13:52938291 G/A cg12458913 chr13:53173898 NA -0.51 -8.12 -0.41 9.43e-15 Lewy body disease; CRC cis rs4819052 0.851 rs4819046 chr21:46664955 C/T cg02159808 chr21:46707872 POFUT2;LOC642852 0.49 6.38 0.33 5.9e-10 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs9527 0.525 rs12770034 chr10:104635595 A/G cg04362960 chr10:104952993 NT5C2 0.6 8.47 0.42 8.16e-16 Arsenic metabolism; CRC cis rs1552244 0.935 rs7649243 chr3:10089470 T/A cg08888203 chr3:10149979 C3orf24 0.73 10.16 0.49 2.86e-21 Alzheimer's disease; CRC cis rs4363385 0.818 rs559236 chr1:153010510 T/C cg25856811 chr1:152973957 SPRR3 -0.25 -6.99 -0.36 1.51e-11 Inflammatory skin disease; CRC cis rs932287 0.536 rs10840160 chr11:9053536 C/T cg12365402 chr11:9010492 NRIP3 -0.42 -6.71 -0.35 8.74e-11 Colonoscopy-negative controls vs population controls; CRC cis rs12928939 0.815 rs34731378 chr16:71745748 C/T cg08717414 chr16:71523259 ZNF19 -0.45 -5.61 -0.3 4.36e-8 Post bronchodilator FEV1; CRC cis rs2153535 0.601 rs2327059 chr6:8447071 A/G cg07606381 chr6:8435919 SLC35B3 0.68 10.84 0.51 1.3e-23 Motion sickness; CRC cis rs12580194 0.556 rs12099811 chr12:55731200 T/A cg19537932 chr12:55886519 OR6C68 -0.63 -8.03 -0.4 1.81e-14 Cancer; CRC cis rs7917772 0.536 rs3961456 chr10:104425304 A/T cg11453585 chr10:104263688 ACTR1A;SUFU -0.84 -13.43 -0.6 4.27e-33 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC cis rs2239547 0.563 rs9876403 chr3:52916916 C/T cg10802521 chr3:52805072 NEK4 -0.47 -6.55 -0.34 2.28e-10 Schizophrenia; CRC cis rs9487051 0.698 rs59502176 chr6:109644719 T/C cg01475377 chr6:109611718 NA -0.35 -5.72 -0.3 2.39e-8 Reticulocyte fraction of red cells; CRC cis rs6835098 1.000 rs6835098 chr4:174089238 T/C cg08422745 chr4:174089978 GALNT7 -0.98 -16.7 -0.68 8.97e-46 Dementia and core Alzheimer's disease neuropathologic changes; CRC cis rs6496667 0.779 rs7169914 chr15:90952049 G/T cg04176472 chr15:90893244 GABARAPL3 0.64 8.17 0.41 6.9e-15 Rheumatoid arthritis; CRC cis rs4072980 0.545 rs12120737 chr1:38422544 C/T cg04673462 chr1:38461896 NA 0.35 5.78 0.3 1.78e-8 Coronary artery disease; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg15273368 chr10:104221031 TMEM180 0.42 6.78 0.35 5.62e-11 Liver disease severity in Alagille syndrome; CRC cis rs9611565 1.000 rs5758314 chr22:41762523 T/G cg03806693 chr22:41940476 POLR3H -0.68 -9.47 -0.46 5.63e-19 Vitiligo; CRC cis rs2274273 0.837 rs10131913 chr14:55787420 A/G cg23234261 chr14:55582407 NA -0.29 -5.78 -0.3 1.73e-8 Protein biomarker; CRC cis rs6951245 0.935 rs112554101 chr7:1065535 A/G cg22907277 chr7:1156413 C7orf50 0.52 6.03 0.32 4.48e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs916888 0.773 rs199451 chr17:44801784 G/A cg17911788 chr17:44343683 NA -0.66 -7.63 -0.39 2.59e-13 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs7552404 0.883 rs77773255 chr1:76217193 G/A cg22875332 chr1:76189707 ACADM 0.7 9.51 0.46 4.14e-19 Blood metabolite levels;Acylcarnitine levels; CRC cis rs2346160 0.899 rs206980 chr6:167691798 A/G cg27333441 chr6:167680455 NA 0.37 5.77 0.3 1.87e-8 Parental extreme longevity (95 years and older); CRC cis rs6088590 0.561 rs6087600 chr20:33157217 T/C cg08999081 chr20:33150536 PIGU 0.63 12.18 0.56 1.97e-28 Coronary artery disease; CRC cis rs732072 0.826 rs604615 chr11:65474813 G/T cg21033440 chr11:65409861 SIPA1 -0.67 -5.7 -0.3 2.7e-8 Inflammatory bowel disease; CRC cis rs4964805 0.913 rs12830701 chr12:104201682 A/C cg02344784 chr12:104178138 NT5DC3 0.53 7.71 0.39 1.49e-13 Attention deficit hyperactivity disorder; CRC cis rs35110281 0.693 rs2838344 chr21:45089877 C/T cg21573476 chr21:45109991 RRP1B -0.4 -6.2 -0.32 1.72e-9 Mean corpuscular volume; CRC cis rs10504229 1.000 rs66477954 chr8:58187810 C/T cg02725872 chr8:58115012 NA -0.38 -6.43 -0.33 4.44e-10 Developmental language disorder (linguistic errors); CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg26614578 chr12:113623930 C12orf52;DDX54 0.5 6.73 0.35 7.36e-11 Thyroid stimulating hormone; CRC cis rs7072216 0.881 rs10883084 chr10:100151189 T/C cg26618903 chr10:100175079 PYROXD2 -0.37 -6.25 -0.33 1.29e-9 Metabolite levels; CRC cis rs2952156 0.920 rs2517954 chr17:37843550 T/C cg00129232 chr17:37814104 STARD3 -0.72 -12.14 -0.56 2.93e-28 Asthma; CRC cis rs6938 0.575 rs12909335 chr15:75214789 T/G cg14664628 chr15:75095509 CSK -0.6 -9.13 -0.45 6.93e-18 Breast cancer; CRC cis rs832540 0.519 rs6895442 chr5:56260998 T/C cg12311346 chr5:56204834 C5orf35 -0.46 -7.19 -0.37 4.25e-12 Coronary artery disease; CRC cis rs8018808 0.935 rs11623826 chr14:77912862 A/C cg20045696 chr14:77926864 AHSA1 0.38 6.05 0.32 3.97e-9 Myeloid white cell count; CRC cis rs10782582 0.593 rs11802717 chr1:76124648 C/T cg03433033 chr1:76189801 ACADM -0.42 -6.1 -0.32 2.94e-9 Daytime sleep phenotypes; CRC trans rs1814175 0.645 rs2140602 chr11:50022800 G/C cg15704280 chr7:45808275 SEPT13 -0.92 -16.92 -0.68 1.2e-46 Height; CRC cis rs875971 0.545 rs801212 chr7:66015630 C/G cg11764359 chr7:65958608 NA -0.46 -5.81 -0.3 1.5e-8 Aortic root size; CRC cis rs73110464 0.505 rs2682296 chr12:53308265 G/A cg06553033 chr12:53270239 NA 0.43 5.88 0.31 1e-8 Cancer (pleiotropy); CRC cis rs8060686 0.920 rs73591976 chr16:67811590 C/A cg07125278 chr16:67683757 RLTPR -0.63 -6.85 -0.35 3.56e-11 HDL cholesterol;Metabolic syndrome; CRC trans rs877282 0.755 rs2486578 chr10:785227 C/T cg22713356 chr15:30763199 NA -0.98 -12.38 -0.56 3.82e-29 Uric acid levels; CRC cis rs9914988 0.887 rs28873200 chr17:27149512 A/G cg20469991 chr17:27169893 C17orf63 -0.59 -7.19 -0.37 4.48e-12 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC trans rs9329221 0.905 rs17765901 chr8:10249480 G/T cg16141378 chr3:129829833 LOC729375 0.43 6.68 0.35 1.03e-10 Neuroticism; CRC cis rs344364 0.511 rs1657134 chr16:1953127 A/G cg03013636 chr16:1946785 NA 0.54 6.79 0.35 5.4e-11 Glomerular filtration rate in chronic kidney disease; CRC cis rs13118159 0.550 rs2336081 chr4:1350322 A/G cg02018176 chr4:1364513 KIAA1530 -0.7 -12.06 -0.55 5.72e-28 Longevity; CRC cis rs1870323 0.689 rs10898483 chr11:86160313 C/T cg01663953 chr11:86133777 CCDC81 -0.31 -5.71 -0.3 2.5e-8 Adverse response to chemotherapy in breast cancer (alopecia) (anti-microtubule); CRC cis rs798554 0.660 rs1182196 chr7:2866478 T/G cg19717773 chr7:2847554 GNA12 -0.49 -8.2 -0.41 5.56e-15 Height; CRC cis rs55702914 0.628 rs55658871 chr2:198278571 G/A cg10820045 chr2:198174542 NA 0.32 5.7 0.3 2.72e-8 Major depression and alcohol dependence; CRC cis rs514406 0.505 rs425520 chr1:53179805 C/G cg08859206 chr1:53392774 SCP2 -0.42 -6.31 -0.33 9.03e-10 Monocyte count; CRC cis rs1003719 0.715 rs9981715 chr21:38499610 C/G cg10648535 chr21:38446584 PIGP;TTC3 -0.48 -6.7 -0.35 8.99e-11 Eye color traits; CRC cis rs2204008 0.619 rs8189576 chr12:38307275 G/A cg13010199 chr12:38710504 ALG10B -0.4 -5.75 -0.3 2.07e-8 Bladder cancer; CRC cis rs11098499 0.575 rs907205 chr4:120238664 G/C cg09307838 chr4:120376055 NA 0.62 9.75 0.47 6.92e-20 Corneal astigmatism; CRC cis rs9494145 0.680 rs35959442 chr6:135424179 C/G cg22676075 chr6:135203613 NA 0.44 5.8 0.3 1.58e-8 Mean platelet volume;Platelet count;Fetal hemoglobin levels in sickle cell anemia;Red blood cell traits; CRC cis rs7591163 1.000 rs4973380 chr2:228725402 T/A cg08034379 chr2:228736324 WDR69 -0.51 -6.86 -0.35 3.47e-11 Blood pressure; CRC cis rs10493773 0.748 rs12758511 chr1:86165987 C/T cg17807903 chr1:86174739 ZNHIT6 -0.52 -11.7 -0.54 1.14e-26 Urate levels in overweight individuals; CRC cis rs3806933 0.522 rs13153937 chr5:110434307 C/T cg04022379 chr5:110408740 TSLP 0.61 8.47 0.42 8.46e-16 Eosinophilic esophagitis; CRC cis rs847577 0.609 rs17435847 chr7:97792820 G/A cg24562669 chr7:97807699 LMTK2 0.79 17.69 0.7 1.07e-49 Breast cancer; CRC cis rs4880487 0.888 rs10794730 chr10:1247022 C/T cg03183215 chr10:1252341 ADARB2 -0.3 -6.71 -0.35 8.67e-11 Migraine; CRC trans rs4263408 0.934 rs9683743 chr4:39703194 A/C cg11284414 chr2:232573146 PTMA -0.42 -6.56 -0.34 2.15e-10 Plasma amyloid beta peptide concentrations (ABx-40); CRC cis rs6963495 0.818 rs55794529 chr7:105165747 T/C cg13798780 chr7:105162888 PUS7 0.69 8.2 0.41 5.36e-15 Bipolar disorder (body mass index interaction); CRC cis rs10197940 0.550 rs77233070 chr2:152416477 G/A cg06191203 chr2:152266755 RIF1 -0.51 -6.71 -0.35 8.33e-11 Lung cancer; CRC trans rs7267979 0.868 rs6138553 chr20:25239233 G/A cg17903999 chr18:56338584 MALT1 -0.41 -6.41 -0.33 5.12e-10 Liver enzyme levels (alkaline phosphatase); CRC cis rs7258465 0.965 rs7256534 chr19:18586791 C/T cg10790698 chr19:18539756 SSBP4 -0.45 -8.72 -0.43 1.41e-16 Breast cancer; CRC cis rs932287 0.505 rs2742536 chr11:8909816 G/C cg14711859 chr11:8959438 ASCL3 0.44 7.5 0.38 5.82e-13 Colonoscopy-negative controls vs population controls; CRC cis rs1109861 0.535 rs3243 chr10:11237928 A/G cg24910943 chr10:11206320 CUGBP2 0.25 6.48 0.34 3.41e-10 Urinary albumin-to-creatinine ratio; CRC cis rs1215050 0.740 rs1214997 chr4:99041533 A/T cg05340658 chr4:99064831 C4orf37 0.49 7.48 0.38 6.88e-13 Waist-to-hip ratio adjusted for body mass index; CRC cis rs4891159 0.790 rs1056714 chr18:74149526 A/G cg24786174 chr18:74118243 ZNF516 -0.84 -14.66 -0.63 8.68e-38 Longevity; CRC cis rs741668 0.894 rs6561282 chr13:46596742 T/G cg06018095 chr13:46550134 ZC3H13 0.43 5.95 0.31 7.04e-9 Cerebrospinal fluid clusterin levels; CRC cis rs7833790 0.750 rs10108955 chr8:82690644 C/T cg27398817 chr8:82754497 SNX16 -0.49 -5.89 -0.31 9.56e-9 Diastolic blood pressure; CRC cis rs28386778 0.687 rs59596917 chr17:61806264 T/A cg06601766 chr17:61851465 DDX42;CCDC47 0.44 5.97 0.31 6.3e-9 Prudent dietary pattern; CRC cis rs896854 0.654 rs10104909 chr8:95977973 C/T cg09323728 chr8:95962352 TP53INP1 -0.43 -7.01 -0.36 1.33e-11 Type 2 diabetes; CRC cis rs2180341 0.960 rs9375503 chr6:127677071 T/C cg27446573 chr6:127587934 RNF146 0.97 13.77 0.6 2.17e-34 Breast cancer; CRC cis rs2072510 0.593 rs2540493 chr12:96415842 A/C cg15438951 chr12:96389694 HAL -0.48 -5.83 -0.31 1.32e-8 Metabolite levels (small molecules and protein measures); CRC cis rs7804356 0.906 rs12540388 chr7:26905731 A/T cg03456212 chr7:26904342 SKAP2 -0.53 -5.93 -0.31 7.6e-9 Type 1 diabetes; CRC cis rs10463316 0.817 rs7701271 chr5:150776708 A/G cg03212797 chr5:150827313 SLC36A1 0.46 7.29 0.37 2.26e-12 Metabolite levels (Pyroglutamine); CRC cis rs752010 0.714 rs6600384 chr1:42085141 A/G cg06885757 chr1:42089581 HIVEP3 -0.45 -8.01 -0.4 2.07e-14 Lupus nephritis in systemic lupus erythematosus; CRC cis rs4713118 0.513 rs149958 chr6:28013617 A/C cg12273811 chr6:28175739 NA 0.56 8.05 0.41 1.52e-14 Parkinson's disease; CRC cis rs7927771 0.832 rs1317164 chr11:47419757 G/T cg18512352 chr11:47633146 NA -0.41 -7.85 -0.4 5.74e-14 Subjective well-being; CRC cis rs6952808 0.823 rs58222895 chr7:1885064 G/A cg21782813 chr7:2030301 MAD1L1 0.39 6.78 0.35 5.54e-11 Bipolar disorder and schizophrenia; CRC cis rs10256972 0.552 rs2960830 chr7:1200641 T/C cg18765753 chr7:1198926 ZFAND2A -0.47 -8.39 -0.42 1.48e-15 Longevity;Endometriosis; CRC cis rs11025559 0.812 rs10766679 chr11:20509190 T/C cg19653624 chr11:20408972 PRMT3 -0.63 -7.76 -0.39 1.1e-13 Pursuit maintenance gain; CRC cis rs3820068 0.532 rs1547034 chr1:15919049 T/A cg13390004 chr1:15929781 NA 0.45 6.3 0.33 9.39e-10 Systolic blood pressure; CRC cis rs7224685 0.501 rs1377806 chr17:4019966 A/G cg09695851 chr17:3907499 NA 0.73 13.38 0.59 6.69e-33 Type 2 diabetes; CRC cis rs1005277 0.522 rs289650 chr10:37975505 G/T cg25427524 chr10:38739819 LOC399744 -0.72 -12.78 -0.58 1.24e-30 Extrinsic epigenetic age acceleration; CRC cis rs10919791 0.501 rs12029406 chr1:199905828 A/G cg07208853 chr1:200005219 NR5A2 -0.24 -6.16 -0.32 2.16e-9 Pancreatic cancer; CRC cis rs10946940 0.965 rs6915266 chr6:27528643 G/A cg03623178 chr6:28175578 NA -0.42 -5.72 -0.3 2.44e-8 Systemic lupus erythematosus; CRC cis rs6662572 0.737 rs10749859 chr1:46314170 C/T cg03123370 chr1:45965343 CCDC163P;MMACHC 0.45 5.85 0.31 1.2e-8 Blood protein levels; CRC cis rs13118159 0.872 rs1882105 chr4:1345956 T/C cg02018176 chr4:1364513 KIAA1530 0.45 7.21 0.37 3.81e-12 Longevity; CRC cis rs6570726 0.791 rs9403729 chr6:145907007 C/T cg05347473 chr6:146136440 FBXO30 0.4 6.04 0.32 4.22e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs9733 0.565 rs7524620 chr1:150616699 C/T cg10589385 chr1:150898437 SETDB1 -0.27 -5.82 -0.31 1.41e-8 Tonsillectomy; CRC cis rs4638749 1.000 rs1466212 chr2:108856532 G/A cg25838818 chr2:108905173 SULT1C2 -0.39 -6.27 -0.33 1.12e-9 Blood pressure; CRC cis rs4363385 0.765 rs1094409 chr1:153021040 T/A cg25856811 chr1:152973957 SPRR3 -0.27 -7.48 -0.38 7.01e-13 Inflammatory skin disease; CRC cis rs9916302 0.861 rs11078896 chr17:37415544 C/T cg00129232 chr17:37814104 STARD3 -0.53 -7.83 -0.4 6.83e-14 Glomerular filtration rate (creatinine); CRC cis rs2257205 0.667 rs4453568 chr17:56934543 A/G cg25885038 chr17:56607967 SEPT4 -0.53 -5.82 -0.31 1.43e-8 Pancreatic cancer; CRC cis rs4654899 0.865 rs1472831 chr1:21435940 C/T cg02927042 chr1:21476669 EIF4G3 -0.51 -7.7 -0.39 1.59e-13 Superior frontal gyrus grey matter volume; CRC cis rs7085104 0.700 rs6163 chr10:104596924 C/A cg08772003 chr10:104629869 AS3MT -0.34 -5.9 -0.31 8.85e-9 Immature fraction of reticulocytes;Schizophrenia; CRC cis rs2067615 0.579 rs10778502 chr12:107090201 T/C cg13491945 chr12:107078410 RFX4 0.34 5.74 0.3 2.18e-8 Heart rate; CRC cis rs798554 0.679 rs7784066 chr7:2819727 T/A cg14895029 chr7:2775587 GNA12 -0.4 -6.23 -0.32 1.42e-9 Height; CRC cis rs6860806 0.661 rs28472559 chr5:131581611 G/A cg02033258 chr5:131593261 PDLIM4 0.39 7.51 0.38 5.48e-13 Breast cancer; CRC cis rs2243480 1.000 rs1796228 chr7:66033084 G/A cg12463550 chr7:65579703 CRCP 0.68 6.14 0.32 2.32e-9 Diabetic kidney disease; CRC cis rs7542091 0.704 rs7537294 chr1:210043777 A/G cg05527609 chr1:210001259 C1orf107 -0.44 -5.86 -0.31 1.15e-8 Monobrow; CRC cis rs7727544 0.735 rs274559 chr5:131720070 A/G cg22638593 chr5:131593259 PDLIM4 -0.31 -5.71 -0.3 2.51e-8 Blood metabolite levels; CRC cis rs801193 1.000 rs10274773 chr7:66133578 G/A cg00343986 chr7:65444356 GUSB -0.49 -7.22 -0.37 3.59e-12 Aortic root size; CRC cis rs9399135 0.967 rs4637662 chr6:135298158 T/C cg24558204 chr6:135376177 HBS1L 0.5 7.79 0.39 8.91e-14 Red blood cell count; CRC cis rs10256972 0.521 rs7457418 chr7:1110255 C/T cg22907277 chr7:1156413 C7orf50 0.45 6.5 0.34 2.93e-10 Longevity;Endometriosis; CRC cis rs1320333 0.772 rs111825088 chr2:695785 T/G cg00500140 chr2:691012 NA 0.59 6.62 0.34 1.48e-10 Obesity-related traits; CRC trans rs4586057 0.812 rs10881845 chr10:92648193 T/C cg26894278 chr13:21016241 CRYL1 0.4 6.52 0.34 2.59e-10 Economic and political preferences (time); CRC cis rs10883723 0.810 rs3740406 chr10:104272789 C/T cg22532475 chr10:104410764 TRIM8 -0.37 -6.79 -0.35 5.28e-11 Allergic disease (asthma, hay fever or eczema); CRC cis rs67311347 0.955 rs11719205 chr3:40417258 G/A cg24209194 chr3:40518798 ZNF619 0.42 6.5 0.34 3e-10 Renal cell carcinoma; CRC cis rs782590 0.869 rs782599 chr2:55847423 C/T cg18811423 chr2:55921094 PNPT1 0.79 14.08 0.61 1.43e-35 Metabolic syndrome; CRC cis rs17021463 0.934 rs28403447 chr4:95257753 G/A cg11021082 chr4:95130006 SMARCAD1 0.53 8.1 0.41 1.08e-14 Testicular germ cell tumor; CRC cis rs9311474 0.935 rs7622851 chr3:52333671 C/G cg18099408 chr3:52552593 STAB1 -0.49 -8.39 -0.42 1.5e-15 Electroencephalogram traits; CRC cis rs7552404 0.727 rs7521344 chr1:76318325 C/T cg03433033 chr1:76189801 ACADM -0.69 -9.31 -0.46 1.85e-18 Blood metabolite levels;Acylcarnitine levels; CRC cis rs67478160 0.643 rs7147171 chr14:104264857 G/A cg01849466 chr14:104193079 ZFYVE21 -0.47 -8.39 -0.42 1.48e-15 Schizophrenia; CRC cis rs6502050 0.835 rs4789675 chr17:80123144 G/A cg13198984 chr17:80129470 CCDC57 0.47 8.35 0.42 1.88e-15 Life satisfaction; CRC trans rs9858542 0.953 rs11706370 chr3:49441091 G/A cg21582582 chr3:182698605 DCUN1D1 -0.52 -6.66 -0.34 1.12e-10 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC trans rs3733585 0.673 rs9994266 chr4:9954450 C/T cg26043149 chr18:55253948 FECH -0.49 -7.52 -0.38 5.31e-13 Cleft plate (environmental tobacco smoke interaction); CRC cis rs7829975 0.517 rs12542733 chr8:8824858 G/T cg08975724 chr8:8085496 FLJ10661 -0.36 -5.74 -0.3 2.18e-8 Mood instability; CRC cis rs798554 0.836 rs2260230 chr7:2822986 T/A cg04166393 chr7:2884313 GNA12 0.51 6.87 0.35 3.3e-11 Height; CRC cis rs62064224 0.554 rs9901737 chr17:30681354 C/G cg18200150 chr17:30822561 MYO1D 0.43 8.42 0.42 1.2e-15 Schizophrenia; CRC cis rs920590 0.721 rs920587 chr8:19663339 C/A cg03894339 chr8:19674705 INTS10 0.43 5.94 0.31 7.22e-9 Acute lymphoblastic leukemia (childhood); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg13487185 chr1:29213677 EPB41 0.38 6.65 0.34 1.25e-10 Liver disease severity in Alagille syndrome; CRC cis rs9818758 0.607 rs67060340 chr3:48915321 C/T cg07636037 chr3:49044803 WDR6 -0.81 -6.68 -0.35 1.04e-10 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; CRC cis rs6062302 0.548 rs4809310 chr20:62228745 G/A cg09650180 chr20:62225654 GMEB2 -0.5 -6.67 -0.35 1.07e-10 Glioblastoma; CRC cis rs561341 0.714 rs75861674 chr17:30304317 A/G cg00745463 chr17:30367425 LRRC37B -0.74 -8.8 -0.44 7.75e-17 Hip circumference adjusted for BMI; CRC cis rs7617480 0.648 rs4858830 chr3:48734002 T/C cg20833759 chr3:49053208 WDR6;DALRD3 0.59 9.09 0.45 9.3e-18 Subjective well-being (multi-trait analysis);Menarche (age at onset); CRC cis rs950027 0.620 rs1153855 chr15:45660758 C/G cg21132104 chr15:45694354 SPATA5L1 0.41 5.92 0.31 8.14e-9 Response to fenofibrate (adiponectin levels); CRC cis rs2415984 0.579 rs12147933 chr14:46972443 G/A cg14871534 chr14:47121158 RPL10L -0.4 -5.96 -0.31 6.51e-9 Number of children ever born; CRC cis rs7552404 0.731 rs10732723 chr1:76392437 C/T cg03433033 chr1:76189801 ACADM -0.64 -8.14 -0.41 8.51e-15 Blood metabolite levels;Acylcarnitine levels; CRC cis rs7487075 0.820 rs7314069 chr12:46708737 T/C cg22049899 chr12:47219821 SLC38A4 0.32 6.1 0.32 3.02e-9 Itch intensity from mosquito bite; CRC cis rs514406 0.607 rs6665324 chr1:53201610 G/A cg27535305 chr1:53392650 SCP2 0.34 6.36 0.33 6.57e-10 Monocyte count; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg09337511 chr12:112856520 PTPN11 0.41 6.48 0.34 3.41e-10 Intelligence (multi-trait analysis); CRC cis rs6502050 0.769 rs9898292 chr17:80100345 A/T cg11859384 chr17:80120422 CCDC57 -0.37 -5.85 -0.31 1.16e-8 Life satisfaction; CRC cis rs4711336 0.809 rs749338 chr6:33653448 A/G cg14003231 chr6:33640908 ITPR3 -0.5 -8.26 -0.41 3.48e-15 Height; CRC cis rs933688 1.000 rs10059163 chr5:90742444 C/T cg02339078 chr5:90679543 LOC100129716;ARRDC3 0.92 14.84 0.63 1.66e-38 Smoking behavior; CRC cis rs3806843 0.735 rs801183 chr5:140091115 C/T cg26395211 chr5:140044315 WDR55 -0.37 -5.6 -0.3 4.46e-8 Depressive symptoms (multi-trait analysis); CRC cis rs11112613 0.713 rs55646142 chr12:105949557 G/A cg03607813 chr12:105948248 NA 0.82 10.85 0.51 1.21e-23 Corrected insulin response;Corrected insulin response adjusted for insulin sensitivity index; CRC cis rs6691722 0.503 rs12086212 chr1:24708740 C/T cg18323236 chr1:24743029 NIPAL3 0.4 5.89 0.31 9.66e-9 Response to interferon beta in multiple sclerosis; CRC cis rs2404618 0.593 rs7815979 chr8:1484887 A/G cg13402656 chr8:1511478 DLGAP2 -0.58 -10.35 -0.5 6.24e-22 Lung cancer; CRC cis rs992157 0.560 rs6738394 chr2:219110625 G/A cg04731861 chr2:219085781 ARPC2 0.37 7.9 0.4 4.12e-14 Colorectal cancer; CRC cis rs875971 0.660 rs12698534 chr7:65986845 C/T cg05627663 chr7:65219948 SNORA22;CCT6P1 0.43 6.46 0.34 3.84e-10 Aortic root size; CRC cis rs68170813 0.559 rs58663672 chr7:106949444 T/C cg02696742 chr7:106810147 HBP1 -0.6 -6.53 -0.34 2.5e-10 Coronary artery disease; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg20340149 chr2:122407145 CLASP1 0.41 6.36 0.33 6.84e-10 Intelligence (multi-trait analysis); CRC cis rs7666738 0.830 rs11944855 chr4:99068258 G/A cg05340658 chr4:99064831 C4orf37 0.6 9.33 0.46 1.57e-18 Colonoscopy-negative controls vs population controls; CRC cis rs4713118 0.824 rs2092075 chr6:27749330 G/C cg20933634 chr6:27740509 NA 0.65 9.13 0.45 7.01e-18 Parkinson's disease; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg15985400 chr11:76091674 PRKRIR 0.46 7.35 0.38 1.55e-12 Liver disease severity in Alagille syndrome; CRC cis rs10256972 0.758 rs7799391 chr7:1082566 C/G cg16145915 chr7:1198662 ZFAND2A -0.3 -5.91 -0.31 8.4e-9 Longevity;Endometriosis; CRC cis rs10170846 0.800 rs10180462 chr2:223526385 C/T cg25565276 chr2:223520875 FARSB 0.47 6.31 0.33 8.84e-10 Schizophrenia (inflammation and infection response interaction); CRC cis rs2980439 0.818 rs2948294 chr8:8094961 A/G cg14979609 chr8:8086686 FLJ10661 -0.36 -5.64 -0.3 3.62e-8 Neuroticism; CRC cis rs796364 1.000 rs769950 chr2:200730028 A/G cg23649088 chr2:200775458 C2orf69 0.55 6.01 0.31 4.84e-9 Schizophrenia; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg21798447 chr4:85504053 CDS1 -0.43 -6.75 -0.35 6.74e-11 Myopia (pathological); CRC cis rs4713118 0.621 rs4713132 chr6:28034035 A/G cg25164649 chr6:28176230 NA 0.7 8.93 0.44 3.12e-17 Parkinson's disease; CRC trans rs60843830 1.000 rs55946380 chr2:268293 A/G cg11347411 chr7:150020925 ACTR3C;LRRC61 0.59 9.19 0.45 4.51e-18 Spherical equivalent (joint analysis main effects and education interaction); CRC cis rs10751667 0.666 rs6597957 chr11:982294 T/A cg01483505 chr11:975446 AP2A2 0.43 6.92 0.36 2.41e-11 Alzheimer's disease (late onset); CRC cis rs10504229 0.775 rs56082079 chr8:58163732 T/C cg21724239 chr8:58056113 NA 0.65 8.46 0.42 8.64e-16 Developmental language disorder (linguistic errors); CRC cis rs12410462 0.681 rs74582965 chr1:227610126 C/T cg23173402 chr1:227635558 NA 0.8 8.37 0.42 1.72e-15 Major depressive disorder; CRC cis rs7553864 0.966 rs11161936 chr1:87614507 G/C cg02083836 chr1:87617350 LOC339524 0.38 6.63 0.34 1.35e-10 Smoking behavior; CRC cis rs9611565 0.512 rs4820444 chr22:42202606 A/G cg03806693 chr22:41940476 POLR3H 1.07 13.65 0.6 6.58e-34 Vitiligo; CRC cis rs12143943 0.866 rs4252745 chr1:204519187 C/G cg17419461 chr1:204415978 PIK3C2B -0.39 -5.95 -0.31 6.76e-9 Cognitive performance; CRC cis rs7914558 1.000 rs7077097 chr10:104945463 G/A cg04362960 chr10:104952993 NT5C2 0.59 8.64 0.43 2.48e-16 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs9611565 0.879 rs5758311 chr22:41759375 G/T cg03806693 chr22:41940476 POLR3H -0.74 -10.42 -0.5 3.82e-22 Vitiligo; CRC cis rs9916302 0.706 rs2879259 chr17:37410892 C/G cg07936489 chr17:37558343 FBXL20 -0.82 -10.35 -0.5 6.5600000000000005e-22 Glomerular filtration rate (creatinine); CRC cis rs12802200 0.535 rs35541591 chr11:570538 C/A cg09218773 chr11:619014 MUPCDH -0.37 -5.8 -0.3 1.57e-8 Systemic lupus erythematosus; CRC cis rs10504229 0.953 rs17805380 chr8:58171128 C/A cg02725872 chr8:58115012 NA -0.38 -6.43 -0.33 4.44e-10 Developmental language disorder (linguistic errors); CRC cis rs9527 0.637 rs11191424 chr10:104625886 G/A cg08772003 chr10:104629869 AS3MT -0.37 -6.35 -0.33 7.1e-10 Arsenic metabolism; CRC cis rs2836950 0.501 rs62223052 chr21:40708702 A/C cg11890956 chr21:40555474 PSMG1 -0.62 -8.83 -0.44 6.4e-17 Menarche (age at onset); CRC cis rs4713118 0.588 rs200994 chr6:27813813 A/C cg23161317 chr6:28129485 ZNF389 -0.46 -6.0 -0.31 5.15e-9 Parkinson's disease; CRC cis rs7726839 0.561 rs3915384 chr5:573395 G/T cg16447950 chr5:562315 NA -0.81 -12.29 -0.56 8.11e-29 Obesity-related traits; CRC cis rs2249625 0.545 rs9791273 chr6:72891016 G/T cg18830697 chr6:72922368 RIMS1 0.41 8.25 0.41 3.95e-15 Acute urticaria and angioedema (non-steroidal anti-inflammatory drug-induced); CRC cis rs2976388 0.525 rs2016749 chr8:143836118 G/A cg22687807 chr8:143858763 LYNX1 -0.63 -11.26 -0.53 4.2e-25 Urinary tract infection frequency; CRC cis rs3760982 1.000 rs12460161 chr19:44293986 C/A cg12072164 chr19:44306565 LYPD5 0.38 5.93 0.31 7.71e-9 Breast cancer (estrogen-receptor negative);Breast cancer; CRC cis rs253959 0.672 rs4920903 chr5:115421589 T/C cg23108291 chr5:115420582 COMMD10 0.44 6.17 0.32 2.04e-9 Bipolar disorder and schizophrenia; CRC cis rs709400 0.930 rs10149249 chr14:104047757 C/T cg12935359 chr14:103987150 CKB -0.37 -5.91 -0.31 8.63e-9 Body mass index; CRC cis rs7089973 0.836 rs1046492 chr10:116624067 C/T cg23260525 chr10:116636907 FAM160B1 0.31 6.73 0.35 7.58e-11 Bipolar disorder or attention deficit hyperactivity disorder; CRC cis rs7412746 0.658 rs4970988 chr1:150950062 A/G cg17724175 chr1:150552817 MCL1 -0.45 -6.55 -0.34 2.28e-10 Melanoma; CRC cis rs2281845 0.533 rs10753891 chr1:201100482 A/G cg24849736 chr1:201084428 NA 0.5 7.66 0.39 2.05e-13 Permanent tooth development; CRC cis rs763121 0.853 rs3788544 chr22:39064966 C/T cg06022373 chr22:39101656 GTPBP1 0.8 12.0 0.55 9.26e-28 Menopause (age at onset); CRC cis rs1552244 0.882 rs6443276 chr3:10008905 C/A cg08888203 chr3:10149979 C3orf24 0.63 8.54 0.43 4.89e-16 Alzheimer's disease; CRC cis rs881375 0.678 rs1930782 chr9:123687905 C/T cg09419670 chr9:123605666 PSMD5;LOC253039 0.45 7.0 0.36 1.47e-11 Rheumatoid arthritis; CRC cis rs9372498 0.536 rs62422221 chr6:118925581 T/C cg24463073 chr6:118973353 C6orf204 0.52 6.67 0.35 1.08e-10 Diastolic blood pressure; CRC cis rs3767633 0.925 rs6427633 chr1:161849569 C/T cg09175582 chr1:161736000 ATF6 0.68 6.13 0.32 2.53e-9 IgG glycosylation; CRC cis rs7666738 0.830 rs13138051 chr4:99050367 C/T cg05340658 chr4:99064831 C4orf37 0.6 9.35 0.46 1.4e-18 Colonoscopy-negative controls vs population controls; CRC cis rs7208859 0.623 rs73269945 chr17:29108759 G/A cg13385521 chr17:29058706 SUZ12P 0.73 8.4 0.42 1.39e-15 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs7246865 0.813 rs13346655 chr19:17176757 C/G cg19418318 chr19:17219073 MYO9B 0.42 6.67 0.35 1.1e-10 Reticulocyte fraction of red cells; CRC cis rs734999 0.588 rs4648653 chr1:2535895 C/T cg20673091 chr1:2541236 MMEL1 0.37 6.02 0.32 4.6e-9 Ulcerative colitis; CRC cis rs12451471 0.559 rs12452263 chr17:78079310 T/C cg21238619 chr17:78079768 GAA -0.34 -5.76 -0.3 1.95e-8 Plateletcrit;Mean corpuscular hemoglobin concentration; CRC cis rs514406 0.505 rs835609 chr1:53170494 T/C cg24675658 chr1:53192096 ZYG11B -0.69 -10.78 -0.51 2.06e-23 Monocyte count; CRC trans rs11225569 0.539 rs7946826 chr11:103340676 C/T cg01615333 chr12:127765195 NA -0.65 -6.17 -0.32 1.98e-9 Diisocyanate-induced asthma; CRC cis rs9462027 0.606 rs2815001 chr6:34634353 G/A cg07306190 chr6:34760872 UHRF1BP1 -0.35 -6.32 -0.33 8.5e-10 Systemic lupus erythematosus; CRC cis rs769267 1.000 rs2074089 chr19:19449603 G/A cg20644253 chr19:19431407 KIAA0892;SF4 -0.41 -5.73 -0.3 2.23e-8 Tonsillectomy; CRC cis rs3106136 0.609 rs1876917 chr4:95099737 G/A cg11021082 chr4:95130006 SMARCAD1 -0.43 -6.16 -0.32 2.15e-9 Capecitabine sensitivity; CRC cis rs9491140 0.539 rs11751246 chr6:124692967 C/T cg22366943 chr6:124882293 NKAIN2 0.57 8.07 0.41 1.3e-14 Neuroticism; CRC cis rs9291683 0.566 rs13144709 chr4:10044182 C/T cg00071950 chr4:10020882 SLC2A9 0.63 11.19 0.52 7.86e-25 Bone mineral density; CRC cis rs2204008 0.630 rs1283300 chr12:38150227 C/T cg26384229 chr12:38710491 ALG10B -0.55 -8.21 -0.41 5.21e-15 Bladder cancer; CRC cis rs12908161 1.000 rs11632465 chr15:85282045 A/T cg17507749 chr15:85114479 UBE2QP1 0.64 9.38 0.46 1.11e-18 Schizophrenia; CRC cis rs4713118 0.662 rs9357060 chr6:28024486 C/G cg18032046 chr6:28092343 ZSCAN16 -0.5 -6.37 -0.33 6.28e-10 Parkinson's disease; CRC cis rs9419702 0.568 rs10782366 chr10:133557866 G/A cg04492858 chr10:133558786 NA 0.38 6.05 0.32 4e-9 Survival in rectal cancer; CRC cis rs7680126 0.626 rs929575 chr4:10196886 C/G cg11266682 chr4:10021025 SLC2A9 -0.45 -6.6 -0.34 1.62e-10 Urate levels in lean individuals;Urate levels in overweight individuals;Urate levels in obese individuals; CRC cis rs5753618 0.519 rs5997939 chr22:31677130 C/G cg07713946 chr22:31675144 LIMK2 -0.39 -5.63 -0.3 3.94e-8 Colorectal cancer; CRC cis rs67311347 0.866 rs9826419 chr3:40352051 G/A cg09455208 chr3:40491958 NA 0.36 6.93 0.36 2.23e-11 Renal cell carcinoma; CRC cis rs7122539 0.603 rs508443 chr11:66509369 C/T cg24851651 chr11:66362959 CCS -0.51 -9.54 -0.47 3.26e-19 HIV-1 susceptibility; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg02902800 chr4:6784175 KIAA0232 0.42 6.78 0.35 5.74e-11 Liver disease severity in Alagille syndrome; CRC cis rs8114671 0.562 rs6120758 chr20:33492523 C/T cg07148914 chr20:33460835 GGT7 0.4 6.48 0.34 3.31e-10 Height; CRC cis rs853679 0.517 rs9393896 chr6:28127703 C/T cg12172441 chr6:28176163 NA 0.64 7.53 0.38 5.03e-13 Depression; CRC cis rs7107174 1.000 rs2510032 chr11:77968631 G/C cg02023728 chr11:77925099 USP35 0.52 7.47 0.38 7.28e-13 Testicular germ cell tumor; CRC cis rs9296736 0.890 rs9382280 chr6:53912613 C/T cg04374786 chr6:53939321 C6orf142 0.44 6.91 0.36 2.56e-11 Liver enzyme levels (gamma-glutamyl transferase); CRC trans rs113835537 0.627 rs4630309 chr11:66333072 A/C cg00692763 chr18:47088373 LIPG 0.56 6.03 0.32 4.39e-9 Airway imaging phenotypes; CRC trans rs17661538 0.772 rs2497804 chr10:18354127 T/C cg13235825 chr11:107574836 NA 0.5 6.06 0.32 3.75e-9 Response to antipsychotic treatment; CRC cis rs9549367 0.707 rs9549353 chr13:113843427 G/A cg24300038 chr13:113819356 PROZ -0.46 -5.62 -0.3 4.15e-8 Platelet distribution width; CRC cis rs6860806 0.507 rs272872 chr5:131675864 C/T cg04518342 chr5:131593106 PDLIM4 -0.42 -6.92 -0.36 2.39e-11 Breast cancer; CRC cis rs7927592 0.956 rs60212556 chr11:68305494 C/T cg16797656 chr11:68205561 LRP5 0.36 5.64 0.3 3.58e-8 Total body bone mineral density; CRC cis rs9322193 0.923 rs11155683 chr6:150100477 T/C cg13206674 chr6:150067644 NUP43 0.57 8.14 0.41 8.29e-15 Lung cancer; CRC cis rs7107174 1.000 rs10899479 chr11:78052539 A/G cg02023728 chr11:77925099 USP35 0.49 7.52 0.38 5.24e-13 Testicular germ cell tumor; CRC cis rs9811920 0.609 rs793501 chr3:99591638 T/C cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G 0.46 6.18 0.32 1.86e-9 Axial length; CRC cis rs2836950 0.565 rs8131132 chr21:40538256 T/C cg17971929 chr21:40555470 PSMG1 -0.59 -8.78 -0.44 9.26e-17 Menarche (age at onset); CRC cis rs7945705 0.967 rs56316046 chr11:8876598 G/T cg12365402 chr11:9010492 NRIP3 0.47 7.56 0.38 4.06e-13 Hemoglobin concentration; CRC cis rs9467711 0.591 rs9467635 chr6:25909166 A/C cg16898833 chr6:26189333 HIST1H4D 0.63 5.76 0.3 1.96e-8 Autism spectrum disorder or schizophrenia; CRC cis rs644799 1.000 rs596277 chr11:95566886 G/A cg25478527 chr11:95522999 CEP57;FAM76B 0.52 7.77 0.39 1.03e-13 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs7246760 1.000 rs73014068 chr19:9922783 T/C cg16876255 chr19:9731953 ZNF561 0.69 5.69 0.3 2.79e-8 Pursuit maintenance gain; CRC cis rs4481887 1.000 rs4554750 chr1:248496530 C/G cg00666640 chr1:248458726 OR2T12 0.55 9.38 0.46 1.1e-18 Common traits (Other); CRC cis rs10504229 0.683 rs2873638 chr8:58114593 G/A cg05313129 chr8:58192883 C8orf71 -0.43 -6.0 -0.31 5.07e-9 Developmental language disorder (linguistic errors); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg02357508 chr15:40331141 SRP14 0.42 6.11 0.32 2.76e-9 Response to antipsychotic treatment; CRC trans rs6472235 0.837 rs2884235 chr8:66934767 T/C cg07884673 chr3:53033167 SFMBT1 -0.45 -6.03 -0.32 4.47e-9 Myopia (pathological);Plateletcrit; CRC trans rs10802346 0.545 rs6662672 chr1:246387611 A/C cg13514129 chr1:39547527 MACF1 0.64 9.59 0.47 2.2e-19 Fractional exhaled nitric oxide (childhood); CRC cis rs853679 0.542 rs34131763 chr6:28075000 A/C cg25164649 chr6:28176230 NA 0.75 9.32 0.46 1.72e-18 Depression; CRC cis rs35110281 0.591 rs86138 chr21:44932398 G/A cg04455712 chr21:45112962 RRP1B 0.39 7.48 0.38 6.96e-13 Mean corpuscular volume; CRC cis rs951366 0.789 rs823121 chr1:205724302 A/G cg24503407 chr1:205819492 PM20D1 -0.82 -12.69 -0.57 2.56e-30 Menarche (age at onset); CRC cis rs524023 1.000 rs9734313 chr11:64358311 C/T cg14139581 chr11:64358342 SLC22A12 -0.39 -6.19 -0.32 1.81e-9 Urate levels in obese individuals; CRC cis rs12760731 0.920 rs74226628 chr1:178484594 T/C cg00404053 chr1:178313656 RASAL2 0.76 8.15 0.41 7.95e-15 Obesity-related traits; CRC cis rs1552244 0.744 rs6763366 chr3:10033544 T/C cg02579736 chr3:10068473 FANCD2;CIDECP 0.93 12.04 0.55 6.69e-28 Alzheimer's disease; CRC cis rs9467711 0.606 rs68112369 chr6:26365759 T/C cg14345882 chr6:26364793 BTN3A2 0.66 5.76 0.3 1.93e-8 Autism spectrum disorder or schizophrenia; CRC cis rs736408 0.609 rs13082960 chr3:52785168 A/C cg18404041 chr3:52824283 ITIH1 -0.42 -8.66 -0.43 2.08e-16 Bipolar disorder; CRC cis rs2882667 0.690 rs3763016 chr5:138270732 C/G cg09476006 chr5:138032270 NA 0.58 10.41 0.5 3.96e-22 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs4743820 0.590 rs7045796 chr9:93919427 G/C cg14446406 chr9:93919335 NA 0.78 14.25 0.62 3.29e-36 Ulcerative colitis;Inflammatory bowel disease; CRC cis rs1728785 0.901 rs6499186 chr16:68660565 C/T cg02972257 chr16:68554789 NA -0.64 -7.5 -0.38 5.91e-13 Ulcerative colitis; CRC cis rs2380220 0.720 rs9374178 chr6:95979974 G/T cg04719120 chr6:96025338 MANEA 0.55 6.47 0.34 3.51e-10 Behavioural disinhibition (generation interaction); CRC trans rs3931020 0.720 rs927904 chr1:75260328 A/G cg26394737 chr14:23067081 ABHD4 0.47 6.04 0.32 4.21e-9 Resistin levels; CRC cis rs17270561 0.609 rs9379786 chr6:25730255 T/C cg17691542 chr6:26056736 HIST1H1C 0.73 9.26 0.45 2.71e-18 Iron status biomarkers; CRC cis rs7584330 0.504 rs7598417 chr2:238435265 C/G cg14458575 chr2:238380390 NA 0.39 5.78 0.3 1.72e-8 Prostate cancer; CRC cis rs2153535 0.541 rs945304 chr6:8442892 A/G cg07606381 chr6:8435919 SLC35B3 0.67 10.81 0.51 1.71e-23 Motion sickness; CRC cis rs12594515 1.000 rs8039974 chr15:45986665 A/G cg19682013 chr15:45996608 NA 0.33 6.7 0.35 8.85e-11 Waist circumference;Weight; CRC cis rs10256972 0.552 rs2949195 chr7:1202705 G/A cg16145915 chr7:1198662 ZFAND2A -0.51 -10.56 -0.5 1.18e-22 Longevity;Endometriosis; CRC cis rs9807989 0.765 rs9807962 chr2:102971664 A/G cg03938978 chr2:103052716 IL18RAP 0.37 5.97 0.31 6.2e-9 Asthma; CRC cis rs6860806 0.661 rs2136187 chr5:131577894 T/C cg20512303 chr5:131592959 PDLIM4 0.37 7.2 0.37 4.02e-12 Breast cancer; CRC cis rs35883536 0.967 rs1582091 chr1:101177133 G/T cg14515779 chr1:101123966 NA -0.35 -6.36 -0.33 6.74e-10 Monocyte count; CRC cis rs9443645 0.901 rs10455356 chr6:79664748 T/C cg11833968 chr6:79620685 NA -0.36 -6.16 -0.32 2.1e-9 Intelligence (multi-trait analysis); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg00626599 chr2:64068905 UGP2 0.4 6.0 0.31 5.3e-9 Intelligence (multi-trait analysis); CRC cis rs4332037 0.707 rs62435130 chr7:1890002 C/T cg23378565 chr7:2036160 MAD1L1 -0.4 -6.04 -0.32 4.11e-9 Bipolar disorder; CRC cis rs10504229 0.953 rs114853497 chr8:58176176 A/T cg22535103 chr8:58192502 C8orf71 -0.82 -12.27 -0.56 9.63e-29 Developmental language disorder (linguistic errors); CRC cis rs9381040 0.610 rs2268195 chr6:41024340 G/A cg09580153 chr6:41068724 NFYA;LOC221442 -0.42 -6.12 -0.32 2.71e-9 Alzheimer's disease (late onset); CRC trans rs9858542 1.000 rs9812791 chr3:49682311 G/A cg21582582 chr3:182698605 DCUN1D1 -0.58 -7.1 -0.36 7.97e-12 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs4692589 0.581 rs6817357 chr4:170962516 A/G cg19918862 chr4:170955249 NA 0.53 6.98 0.36 1.66e-11 Anxiety disorder; CRC cis rs6089584 0.962 rs6142913 chr20:60566950 A/G cg23463467 chr20:60627584 TAF4 0.33 5.94 0.31 7.37e-9 Body mass index; CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg08448040 chr3:13521693 HDAC11 -0.51 -6.08 -0.32 3.36e-9 Diisocyanate-induced asthma; CRC cis rs11628318 0.614 rs1190338 chr14:103105792 T/G cg23071808 chr14:103021642 NA -0.64 -7.21 -0.37 3.77e-12 Platelet count; CRC cis rs7927771 0.725 rs11570094 chr11:47359706 A/C cg05585544 chr11:47624801 NA 0.43 6.96 0.36 1.84e-11 Subjective well-being; CRC cis rs9611565 0.592 rs5996037 chr22:41965292 A/G cg03806693 chr22:41940476 POLR3H -0.9 -11.19 -0.53 7.31e-25 Vitiligo; CRC cis rs2075371 0.966 rs2244690 chr7:133987039 A/G cg02659138 chr7:134003124 SLC35B4 0.4 6.96 0.36 1.84e-11 Mean platelet volume; CRC cis rs477895 0.713 rs3802933 chr11:63988102 C/T cg23719950 chr11:63933701 MACROD1 -0.64 -8.09 -0.41 1.17e-14 Mean platelet volume; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg11625451 chr16:81349061 GAN 0.38 5.96 0.31 6.37e-9 Liver disease severity in Alagille syndrome; CRC cis rs7605827 0.930 rs11685629 chr2:15662271 A/T cg19274914 chr2:15703543 NA 0.39 5.87 0.31 1.07e-8 Educational attainment (years of education); CRC cis rs1322512 0.848 rs2695247 chr6:152948596 G/T cg03415253 chr6:152958462 SYNE1 -0.42 -6.43 -0.33 4.53e-10 Tonometry; CRC cis rs6496667 0.865 rs16944212 chr15:90888049 C/G cg04176472 chr15:90893244 GABARAPL3 -0.55 -6.6 -0.34 1.64e-10 Rheumatoid arthritis; CRC cis rs10504229 0.724 rs73603871 chr8:58107612 A/G cg02725872 chr8:58115012 NA -0.66 -11.36 -0.53 1.85e-25 Developmental language disorder (linguistic errors); CRC cis rs7224685 0.569 rs8082483 chr17:4000849 G/A cg05562828 chr17:3906858 NA 0.49 6.48 0.34 3.32e-10 Type 2 diabetes; CRC cis rs7772486 0.764 rs2265468 chr6:146218346 A/C cg23711669 chr6:146136114 FBXO30 0.74 12.94 0.58 3.06e-31 Lobe attachment (rater-scored or self-reported); CRC cis rs317689 0.819 rs317667 chr12:69703754 G/T cg14784868 chr12:69753453 YEATS4 0.44 5.7 0.3 2.73e-8 Response to diuretic therapy; CRC cis rs13191362 1.000 rs67747005 chr6:163150845 G/A cg21926612 chr6:163149169 PACRG;PARK2 0.82 11.44 0.53 9.32e-26 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs9486719 0.895 rs34051754 chr6:97007754 A/T cg06623918 chr6:96969491 KIAA0776 -0.82 -9.53 -0.47 3.58e-19 Migraine;Coronary artery disease; CRC cis rs4713118 0.662 rs9468271 chr6:28024570 A/G cg23161317 chr6:28129485 ZNF389 0.45 5.81 0.3 1.5e-8 Parkinson's disease; CRC cis rs2075371 0.863 rs9641966 chr7:133961205 G/A cg02659138 chr7:134003124 SLC35B4 0.39 6.62 0.34 1.46e-10 Mean platelet volume; CRC cis rs561341 0.609 rs11658984 chr17:30186612 C/T cg12193833 chr17:30244370 NA 0.45 6.01 0.31 4.79e-9 Hip circumference adjusted for BMI; CRC trans rs1814175 0.502 rs12365889 chr11:49623034 G/A cg03929089 chr4:120376271 NA -0.77 -10.85 -0.51 1.17e-23 Height; CRC cis rs7312933 0.618 rs6582390 chr12:42634586 C/T cg19980929 chr12:42632907 YAF2 0.47 7.1 0.36 7.76e-12 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CRC cis rs9910055 0.762 rs2631299 chr17:42219773 G/T cg16434002 chr17:42200994 HDAC5 -0.43 -5.84 -0.31 1.26e-8 Total body bone mineral density; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg06622468 chr19:10491460 TYK2 0.46 7.4 0.38 1.17e-12 Liver disease severity in Alagille syndrome; CRC cis rs1691799 0.806 rs1168319 chr12:66744857 T/A cg16791601 chr12:66731901 HELB -0.73 -12.99 -0.58 1.92e-31 White blood cell count (basophil); CRC cis rs10504229 0.683 rs61306359 chr8:58134646 G/A cg05313129 chr8:58192883 C8orf71 -0.43 -6.11 -0.32 2.74e-9 Developmental language disorder (linguistic errors); CRC cis rs1552244 1.000 rs68045038 chr3:10151828 A/G cg18598329 chr3:10140678 FANCD2;C3orf24 -0.89 -11.92 -0.55 1.84e-27 Alzheimer's disease; CRC cis rs728616 0.867 rs76239460 chr10:81723227 C/T cg11900509 chr10:81946545 ANXA11 -0.66 -6.6 -0.34 1.67e-10 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs3091242 0.933 rs4649084 chr1:25752617 A/G cg23205692 chr1:25664452 TMEM50A 0.41 5.86 0.31 1.13e-8 Erythrocyte sedimentation rate; CRC cis rs853679 0.760 rs9368563 chr6:28208558 A/G cg15845792 chr6:28175446 NA 0.74 7.78 0.39 9.45e-14 Depression; CRC cis rs7119 0.717 rs12902925 chr15:77819141 T/C cg10437265 chr15:77819839 NA 0.69 12.75 0.57 1.6e-30 Type 2 diabetes; CRC cis rs4713118 0.869 rs9295743 chr6:27715102 G/C cg03623178 chr6:28175578 NA 0.67 9.54 0.47 3.41e-19 Parkinson's disease; CRC cis rs4862750 0.914 rs1991256 chr4:187875330 A/G cg27532560 chr4:187881888 NA -0.56 -10.16 -0.49 2.83e-21 Lobe attachment (rater-scored or self-reported); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg27146808 chr19:14200528 SAMD1 0.43 6.77 0.35 6.07e-11 Liver disease severity in Alagille syndrome; CRC cis rs13108904 0.539 rs13140926 chr4:1340939 G/A cg24560729 chr4:1342394 KIAA1530 0.39 6.27 0.33 1.15e-9 Obesity-related traits; CRC cis rs2046867 0.661 rs28599586 chr3:72907185 A/G cg25664220 chr3:72788482 NA -0.38 -5.83 -0.31 1.35e-8 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; CRC cis rs9818758 0.607 rs73084135 chr3:49272218 A/G cg00383909 chr3:49044727 WDR6 1.43 12.88 0.58 5.16e-31 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; CRC cis rs514406 0.679 rs960570 chr1:53237763 A/G cg24675658 chr1:53192096 ZYG11B 0.79 12.27 0.56 9.13e-29 Monocyte count; CRC cis rs4841097 0.806 rs6992247 chr8:8948469 G/T cg06636001 chr8:8085503 FLJ10661 0.57 8.37 0.42 1.7e-15 Platelet distribution width; CRC cis rs1707322 0.721 rs11211149 chr1:46112218 T/C cg06784218 chr1:46089804 CCDC17 0.64 12.03 0.55 6.98e-28 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs12908161 1.000 rs62021219 chr15:85256159 C/T cg17507749 chr15:85114479 UBE2QP1 0.63 9.11 0.45 8.42e-18 Schizophrenia; CRC trans rs561341 0.629 rs7216107 chr17:30224419 G/A cg20587970 chr11:113659929 NA -0.54 -7.41 -0.38 1.07e-12 Hip circumference adjusted for BMI; CRC cis rs929354 0.772 rs1182442 chr7:157026633 G/A cg17757837 chr7:157058334 UBE3C -0.75 -12.98 -0.58 2.18e-31 Body mass index; CRC cis rs12023718 0.588 rs6659392 chr1:178598873 C/T cg00404053 chr1:178313656 RASAL2 0.59 7.41 0.38 1.04e-12 Obesity-related traits; CRC trans rs7395662 0.784 rs2170661 chr11:48378186 C/T cg21153622 chr11:89784906 NA -0.47 -7.26 -0.37 2.85e-12 HDL cholesterol; CRC cis rs4665809 1.000 rs13030858 chr2:26315451 G/A cg26119090 chr2:26468346 HADHA;HADHB -0.61 -7.91 -0.4 3.92e-14 Gut microbiome composition (summer); CRC cis rs10751667 0.666 rs10902249 chr11:958566 C/T cg23136738 chr11:925521 AP2A2 0.43 7.25 0.37 3.05e-12 Alzheimer's disease (late onset); CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg01426831 chr19:12098817 NA -0.51 -6.08 -0.32 3.41e-9 Diisocyanate-induced asthma; CRC cis rs9911578 0.967 rs6503890 chr17:57064167 A/G cg12560992 chr17:57184187 TRIM37 0.92 16.94 0.68 9.76e-47 Intelligence (multi-trait analysis); CRC cis rs172166 0.694 rs1150666 chr6:28123928 T/C cg21251018 chr6:28226885 NKAPL 0.46 6.95 0.36 2e-11 Cardiac Troponin-T levels; CRC cis rs9649213 0.593 rs3801264 chr7:97950620 A/G cg21770322 chr7:97807741 LMTK2 0.51 8.29 0.42 2.89e-15 Prostate cancer (SNP x SNP interaction); CRC trans rs4263408 0.934 rs9683743 chr4:39703194 A/C cg15568066 chr10:43904326 HNRNPF -0.43 -6.32 -0.33 8.27e-10 Plasma amyloid beta peptide concentrations (ABx-40); CRC cis rs490234 0.783 rs2416967 chr9:128440014 T/C cg14078157 chr9:128172775 NA -0.35 -5.69 -0.3 2.88e-8 Mean arterial pressure; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg05922971 chr5:43121458 ZNF131 -0.44 -6.62 -0.34 1.47e-10 Myopia (pathological); CRC cis rs654950 0.875 rs633297 chr1:41985453 A/C cg06885757 chr1:42089581 HIVEP3 0.33 5.78 0.3 1.76e-8 Airway imaging phenotypes; CRC cis rs1218582 0.741 rs7544528 chr1:154844585 C/T cg03351412 chr1:154909251 PMVK 0.5 7.78 0.39 9.4e-14 Prostate cancer; CRC cis rs12760731 0.668 rs4573483 chr1:178268075 C/A cg00404053 chr1:178313656 RASAL2 0.69 8.73 0.43 1.35e-16 Obesity-related traits; CRC cis rs7811142 0.887 rs35111986 chr7:100000274 C/A cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.17 16.33 0.67 2.47e-44 Platelet count; CRC trans rs8002861 0.870 rs2875541 chr13:44417441 G/T cg17145862 chr1:211918768 LPGAT1 0.72 14.34 0.62 1.46e-36 Leprosy; CRC cis rs9322193 0.884 rs11155689 chr6:150129606 T/C cg07701084 chr6:150067640 NUP43 0.48 6.7 0.35 8.9e-11 Lung cancer; CRC trans rs2840044 0.554 rs225267 chr17:33964228 T/C cg19694781 chr19:47549865 TMEM160 -1.05 -14.7 -0.63 5.76e-38 Response to radiotherapy in cancer (late toxicity); CRC cis rs9549367 0.789 rs9604040 chr13:113910611 A/G cg24300038 chr13:113819356 PROZ 0.45 5.98 0.31 5.73e-9 Platelet distribution width; CRC cis rs7659604 0.537 rs6823818 chr4:122731699 G/C cg06713675 chr4:122721982 EXOSC9 -0.51 -8.24 -0.41 4.19e-15 Type 2 diabetes; CRC cis rs929354 1.000 rs1182413 chr7:157058557 G/A cg16102536 chr7:156981717 UBE3C -0.37 -6.27 -0.33 1.1e-9 Body mass index; CRC cis rs798554 0.660 rs2283783 chr7:2855326 G/A cg04166393 chr7:2884313 GNA12 0.38 5.68 0.3 3.04e-8 Height; CRC cis rs2228479 0.850 rs1800344 chr16:89816367 T/G cg06656553 chr16:89960601 TCF25 -0.69 -5.74 -0.3 2.15e-8 Skin colour saturation; CRC cis rs3733585 0.673 rs4447861 chr4:9953940 C/T cg11266682 chr4:10021025 SLC2A9 -0.47 -9.62 -0.47 1.76e-19 Cleft plate (environmental tobacco smoke interaction); CRC cis rs3768617 0.528 rs10737241 chr1:183098208 C/T ch.1.3577855R chr1:183094577 LAMC1 0.9 15.69 0.65 8.35e-42 Fuchs's corneal dystrophy; CRC cis rs10504229 0.636 rs72649133 chr8:58054681 G/A cg21724239 chr8:58056113 NA 0.79 9.65 0.47 1.4e-19 Developmental language disorder (linguistic errors); CRC cis rs6964587 0.967 rs10429103 chr7:91598443 T/A cg17063962 chr7:91808500 NA 0.8 14.25 0.62 3.19e-36 Breast cancer; CRC cis rs1451375 0.959 rs1451373 chr7:50622606 A/G cg18232548 chr7:50535776 DDC 0.47 6.62 0.34 1.43e-10 Malaria; CRC cis rs57221529 0.766 rs58015612 chr5:580665 A/T cg17948913 chr5:572064 NA 0.56 6.29 0.33 1e-9 Lung disease severity in cystic fibrosis; CRC cis rs8180040 0.783 rs11710121 chr3:47351501 T/G cg10298567 chr3:47292165 KIF9 0.39 5.95 0.31 6.69e-9 Colorectal cancer; CRC cis rs9560113 0.959 rs4773385 chr13:112178452 C/T cg10483660 chr13:112241077 NA 0.36 5.82 0.31 1.39e-8 Menarche (age at onset); CRC cis rs875971 0.862 rs7803416 chr7:65954199 A/G cg18876405 chr7:65276391 NA 0.52 8.9 0.44 3.86e-17 Aortic root size; CRC cis rs35883536 0.647 rs12046413 chr1:101047430 T/C cg06223162 chr1:101003688 GPR88 -0.34 -6.15 -0.32 2.21e-9 Monocyte count; CRC cis rs3849570 0.565 rs1851926 chr3:81977231 A/C cg07356753 chr3:81810745 GBE1 -0.47 -6.36 -0.33 6.72e-10 Waist circumference;Body mass index; CRC trans rs703108 0.731 rs7898954 chr10:22323646 A/G cg22716984 chr17:31203477 MYO1D -0.52 -6.69 -0.35 9.66e-11 Monocyte percentage of white cells; CRC cis rs6502050 0.835 rs62078306 chr17:80085341 A/G cg11859384 chr17:80120422 CCDC57 0.37 5.82 0.31 1.36e-8 Life satisfaction; CRC trans rs360798 0.512 rs11893131 chr2:63079528 C/A cg05376469 chr2:102649931 NA -0.37 -6.17 -0.32 1.95e-9 Coronary artery disease; CRC cis rs6502050 0.835 rs4459614 chr17:80086597 C/T cg19223190 chr17:80058835 NA -0.4 -6.24 -0.33 1.33e-9 Life satisfaction; CRC cis rs10857712 0.703 rs12253520 chr10:135235321 C/A cg19623624 chr10:135278901 LOC619207 -0.35 -5.75 -0.3 2.07e-8 Systemic lupus erythematosus; CRC cis rs12711979 0.765 rs6715805 chr2:3821117 T/C cg17052675 chr2:3827356 NA -0.57 -10.83 -0.51 1.38e-23 Itch intensity from mosquito bite adjusted by bite size; CRC cis rs17767392 0.958 rs7144829 chr14:72066456 G/A cg13720639 chr14:72061746 SIPA1L1 0.56 7.06 0.36 1.02e-11 Mitral valve prolapse; CRC cis rs7937682 0.889 rs542424 chr11:111477698 T/C cg09085632 chr11:111637200 PPP2R1B -1.0 -19.99 -0.74 9.26e-59 Primary sclerosing cholangitis; CRC trans rs11098499 0.754 rs10213554 chr4:120260785 A/G cg25214090 chr10:38739885 LOC399744 -0.55 -8.53 -0.43 5.38e-16 Corneal astigmatism; CRC cis rs8049040 0.609 rs16972805 chr16:71478249 A/G cg08717414 chr16:71523259 ZNF19 0.42 5.88 0.31 9.95e-9 Blood protein levels; CRC cis rs992157 0.835 rs2292555 chr2:219146882 G/C cg04731861 chr2:219085781 ARPC2 0.34 6.94 0.36 2.12e-11 Colorectal cancer; CRC cis rs2688608 0.592 rs11000757 chr10:75486815 T/C cg00564723 chr10:75632066 CAMK2G -0.22 -5.61 -0.3 4.35e-8 Inflammatory bowel disease; CRC cis rs7945705 0.967 rs10840141 chr11:8902218 T/C cg00186954 chr11:8933980 ST5;C11orf17 0.47 7.42 0.38 1.03e-12 Hemoglobin concentration; CRC cis rs801193 0.844 rs2244022 chr7:66202430 A/G cg18876405 chr7:65276391 NA 0.58 10.21 0.49 1.96e-21 Aortic root size; CRC trans rs116095464 0.614 rs10059220 chr5:242813 C/T cg00938859 chr5:1591904 SDHAP3 0.65 5.97 0.31 6.02e-9 Breast cancer; CRC cis rs6502050 0.835 rs9646397 chr17:80083534 G/A cg09264619 chr17:80180166 NA 0.36 6.08 0.32 3.4e-9 Life satisfaction; CRC trans rs12188164 0.714 rs11741954 chr5:421455 G/T cg15371732 chr17:78194151 SLC26A11;SGSH 0.46 6.34 0.33 7.53e-10 Cystic fibrosis severity; CRC cis rs904251 0.523 rs914348 chr6:37484729 G/A cg25019722 chr6:37503610 NA -0.46 -8.54 -0.43 5.12e-16 Cognitive performance; CRC cis rs6502050 0.835 rs8073645 chr17:80110957 C/T cg13198984 chr17:80129470 CCDC57 0.46 8.16 0.41 6.94e-15 Life satisfaction; CRC cis rs73195822 0.614 rs17683336 chr12:111212712 C/T cg12870014 chr12:110450643 ANKRD13A 0.66 7.22 0.37 3.66e-12 Itch intensity from mosquito bite; CRC cis rs6696846 0.765 rs72757524 chr1:205086473 C/T cg00857998 chr1:205179979 DSTYK 0.45 6.11 0.32 2.74e-9 Red blood cell count; CRC cis rs6546550 0.935 rs3214007 chr2:70098808 A/G cg02498382 chr2:70120550 SNRNP27 -0.48 -7.84 -0.4 6.21e-14 Prevalent atrial fibrillation; CRC cis rs3931020 0.548 rs969435 chr1:75273866 A/G cg21906852 chr1:75198582 TYW3;CRYZ -0.46 -5.85 -0.31 1.18e-8 Resistin levels; CRC cis rs853679 0.542 rs9393892 chr6:28081394 A/G cg02683197 chr6:28174875 NA 0.84 10.36 0.5 6.08e-22 Depression; CRC cis rs546131 1.000 rs546131 chr11:34851760 G/C cg06937548 chr11:34938143 PDHX;APIP 0.39 5.86 0.31 1.1e-8 Lung disease severity in cystic fibrosis; CRC cis rs1401999 0.606 rs939335 chr3:183745663 A/G cg20387954 chr3:183756860 HTR3D 0.38 6.5 0.34 2.95e-10 Anterior chamber depth; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg13744070 chr11:61197882 SDHAF2;CPSF7 0.41 5.98 0.31 5.85e-9 Intelligence (multi-trait analysis); CRC cis rs2108622 0.683 rs112571591 chr19:15977445 G/A cg13772218 chr19:15982569 NA 0.47 6.59 0.34 1.74e-10 Circulating phylloquinone levels;Vitamin E levels;Acenocoumarol maintenance dosage;Response to Vitamin E supplementation;Metabolite levels;Warfarin maintenance dose; CRC cis rs7224737 0.956 rs7208907 chr17:40284783 C/T cg20291162 chr17:40259547 DHX58 -0.55 -7.98 -0.4 2.46e-14 Fibrinogen levels; CRC cis rs317689 0.788 rs317679 chr12:69693172 A/C cg14784868 chr12:69753453 YEATS4 0.45 5.76 0.3 1.94e-8 Response to diuretic therapy; CRC cis rs2011503 0.941 rs998732 chr19:19378671 A/G cg11584989 chr19:19387371 SF4 0.6 6.76 0.35 6.25e-11 Bipolar disorder; CRC cis rs2645694 0.626 rs2703121 chr4:77822328 C/G cg03477792 chr4:77819574 ANKRD56 0.45 6.48 0.34 3.36e-10 Emphysema distribution in smoking; CRC cis rs853679 0.517 rs12174753 chr6:28042465 C/G cg03623178 chr6:28175578 NA 0.93 12.11 0.56 3.53e-28 Depression; CRC cis rs9933309 1.000 rs9933309 chr16:88844932 A/G cg04602696 chr16:88846723 FAM38A -0.5 -8.44 -0.42 1.04e-15 Glycated hemoglobin levels; CRC cis rs1218582 0.661 rs4845695 chr1:154911798 A/G cg16680214 chr1:154839983 KCNN3 -0.49 -8.76 -0.43 1.06e-16 Prostate cancer; CRC trans rs9388451 0.839 rs980014 chr6:126068001 T/G cg05039488 chr6:79577232 IRAK1BP1 -0.59 -9.03 -0.45 1.43e-17 Brugada syndrome; CRC cis rs853679 0.546 rs200996 chr6:27811828 G/A cg23259851 chr6:27775964 HIST1H2AI;HIST1H2BL 0.67 5.72 0.3 2.33e-8 Depression; CRC trans rs3780486 0.629 rs10971439 chr9:33180813 C/T cg20290983 chr6:43655470 MRPS18A -0.94 -11.33 -0.53 2.5e-25 IgG glycosylation; CRC trans rs17106184 1.000 rs11205777 chr1:51286954 T/A cg02869289 chr19:46177325 MIR642;GIPR 0.62 6.07 0.32 3.51e-9 Type 2 diabetes; CRC cis rs8032158 0.702 rs12910830 chr15:56122664 T/C cg02198044 chr15:56286336 NEDD4 -0.36 -5.73 -0.3 2.33e-8 Keloid; CRC cis rs7666738 0.830 rs2865979 chr4:99027137 T/C cg05340658 chr4:99064831 C4orf37 0.61 9.42 0.46 8.23e-19 Colonoscopy-negative controls vs population controls; CRC cis rs2404602 0.669 rs12148877 chr15:76919959 T/G cg22467129 chr15:76604101 ETFA -0.38 -6.32 -0.33 8.49e-10 Blood metabolite levels; CRC cis rs7258465 1.000 rs4808136 chr19:18618867 A/G cg01065977 chr19:18549689 ISYNA1 0.39 6.04 0.32 4.05e-9 Breast cancer; CRC cis rs155076 1.000 rs566364 chr13:21837583 T/C cg25811766 chr13:21894605 NA -0.59 -6.07 -0.32 3.57e-9 White matter hyperintensity burden; CRC cis rs12936587 0.601 rs11655881 chr17:17553133 G/A cg04398451 chr17:18023971 MYO15A 0.35 5.79 0.3 1.62e-8 Hip circumference;Coronary artery disease or large artery stroke;Coronary heart disease;Coronary artery disease; CRC cis rs10743315 0.557 rs17505005 chr12:19296294 C/T cg02471346 chr12:19282374 PLEKHA5 0.75 6.29 0.33 1.02e-9 Gut microbiota (bacterial taxa); CRC cis rs4665809 0.590 rs9309474 chr2:26448830 T/A cg25036284 chr2:26402008 FAM59B -0.61 -7.76 -0.39 1.09e-13 Gut microbiome composition (summer); CRC cis rs10788264 0.504 rs4751885 chr10:124020305 G/T cg09507567 chr10:124027408 NA 0.35 7.51 0.38 5.48e-13 Total body bone mineral density; CRC cis rs9549367 0.789 rs2287251 chr13:113889499 A/G cg18105134 chr13:113819100 PROZ -0.72 -10.75 -0.51 2.75e-23 Platelet distribution width; CRC trans rs208520 1.000 rs72880045 chr6:66965232 A/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.89 10.95 0.52 5.28e-24 Exhaled nitric oxide output; CRC cis rs6558530 0.897 rs10481354 chr8:1704030 A/G cg19131313 chr8:1704013 NA 0.44 6.23 0.33 1.39e-9 Systolic blood pressure; CRC cis rs4555082 0.830 rs2816614 chr14:105727359 C/T cg18132624 chr14:105716052 BTBD6;BRF1 -0.46 -7.34 -0.38 1.67e-12 Mean platelet volume;Platelet distribution width; CRC cis rs6570726 0.935 rs372378 chr6:145816227 A/G cg23711669 chr6:146136114 FBXO30 0.68 12.05 0.55 6.18e-28 Lobe attachment (rater-scored or self-reported); CRC trans rs7615952 0.512 rs11921452 chr3:125359750 A/G cg17147758 chr8:6949321 NA -0.52 -7.2 -0.37 4.24e-12 Blood pressure (smoking interaction); CRC trans rs10411161 1.000 rs8109345 chr19:52364933 T/C cg22319618 chr22:45562946 NUP50 -0.52 -6.03 -0.32 4.4e-9 Breast cancer; CRC cis rs2032447 0.839 rs6901039 chr6:26000885 A/C cg12588279 chr6:26043732 HIST1H2BB 0.45 6.68 0.35 1.02e-10 Intelligence (multi-trait analysis); CRC cis rs10876993 0.890 rs7976852 chr12:58100551 T/G cg15848620 chr12:58087721 OS9 -0.61 -8.3 -0.42 2.69e-15 Celiac disease or Rheumatoid arthritis; CRC cis rs9322193 0.923 rs4455682 chr6:150021297 C/T cg07701084 chr6:150067640 NUP43 0.56 8.29 0.42 2.92e-15 Lung cancer; CRC cis rs7772486 0.754 rs9497419 chr6:146142609 T/C cg13319975 chr6:146136371 FBXO30 -0.44 -6.58 -0.34 1.83e-10 Lobe attachment (rater-scored or self-reported); CRC cis rs10207060 0.500 rs10181238 chr2:240709496 G/A cg07506560 chr2:240697449 NA 0.48 6.37 0.33 6.49e-10 Obesity-related traits; CRC cis rs950169 0.922 rs4842941 chr15:84831312 G/C cg17507749 chr15:85114479 UBE2QP1 -0.75 -11.08 -0.52 1.9e-24 Schizophrenia; CRC cis rs7208859 0.673 rs9899349 chr17:29200122 C/T cg01831904 chr17:28903510 LRRC37B2 -0.55 -5.77 -0.3 1.88e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs524281 0.692 rs11227395 chr11:65829637 A/C cg16950941 chr11:66035639 RAB1B -0.59 -7.95 -0.4 3.02e-14 Electroencephalogram traits; CRC cis rs6964587 1.000 rs12666179 chr7:91574110 T/C cg17063962 chr7:91808500 NA -0.82 -14.44 -0.62 5.88e-37 Breast cancer; CRC cis rs3793683 0.520 rs12769959 chr10:134579026 A/C cg27286337 chr10:134555280 INPP5A 0.72 9.18 0.45 5.09e-18 Migraine; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg12595647 chr1:54411915 LRRC42;HSPB11 0.42 6.74 0.35 7.17e-11 Liver disease severity in Alagille syndrome; CRC cis rs9487051 0.676 rs6913093 chr6:109636205 T/C cg12927641 chr6:109611667 NA -0.35 -6.17 -0.32 2e-9 Reticulocyte fraction of red cells; CRC cis rs6952808 0.531 rs3778991 chr7:2172455 G/A cg22963979 chr7:1858916 MAD1L1 -0.41 -5.78 -0.3 1.69e-8 Bipolar disorder and schizophrenia; CRC cis rs6570726 1.000 rs374464 chr6:145846679 A/C cg13319975 chr6:146136371 FBXO30 -0.38 -5.73 -0.3 2.32e-8 Lobe attachment (rater-scored or self-reported); CRC cis rs13108904 0.935 rs1732102 chr4:1277924 T/C cg19318889 chr4:1322082 MAEA -0.4 -6.0 -0.31 5.09e-9 Obesity-related traits; CRC cis rs826838 0.935 rs10875816 chr12:38955014 C/A cg26384229 chr12:38710491 ALG10B 0.72 9.91 0.48 1.98e-20 Heart rate; CRC cis rs11098499 0.754 rs34425882 chr4:120253177 G/A cg24375607 chr4:120327624 NA 0.47 7.6 0.39 3.06e-13 Corneal astigmatism; CRC cis rs7772486 0.686 rs9403746 chr6:146103768 C/A cg23711669 chr6:146136114 FBXO30 -0.68 -11.47 -0.53 7.66e-26 Lobe attachment (rater-scored or self-reported); CRC cis rs216303 1.000 rs216301 chr12:6157988 A/G cg19878637 chr12:6148451 VWF -0.54 -6.0 -0.31 5.32e-9 Low vWF levels; CRC cis rs7916697 0.593 rs3740587 chr10:70020802 G/A cg06988349 chr10:69991859 ATOH7 -0.37 -6.95 -0.36 1.96e-11 Optic disc area; CRC cis rs838147 0.507 rs1704773 chr19:49209566 A/G cg21064579 chr19:49206444 FUT2 0.5 8.73 0.43 1.3e-16 Dietary macronutrient intake; CRC cis rs977987 0.806 rs72787160 chr16:75445162 G/C cg03315344 chr16:75512273 CHST6 0.54 9.11 0.45 7.98e-18 Dupuytren's disease; CRC trans rs2012709 0.837 rs72739259 chr5:32586387 T/C cg03755955 chr8:6424269 MCPH1 0.47 7.03 0.36 1.18e-11 Breast cancer; CRC cis rs853679 0.517 rs4713152 chr6:28137454 G/A cg25164649 chr6:28176230 NA 0.78 9.66 0.47 1.33e-19 Depression; CRC cis rs1448094 0.512 rs12314274 chr12:86249196 A/G cg19622623 chr12:86230825 RASSF9 -0.42 -6.88 -0.35 3.03e-11 Major depressive disorder; CRC cis rs9303401 0.580 rs2013166 chr17:56637630 C/T cg10487724 chr17:56770010 TEX14;RAD51C 0.78 9.59 0.47 2.24e-19 Cognitive test performance; CRC cis rs3823572 0.504 rs10255763 chr7:133632286 A/G cg03336402 chr7:133662267 EXOC4 0.63 9.63 0.47 1.65e-19 Intelligence (multi-trait analysis); CRC cis rs2228479 0.850 rs12599473 chr16:89827435 A/C cg06558623 chr16:89946397 TCF25 1.13 10.45 0.5 2.85e-22 Skin colour saturation; CRC cis rs28386778 0.863 rs2251164 chr17:61884120 G/A cg25654072 chr17:61904446 PSMC5;FTSJ3 0.72 11.24 0.53 5.2e-25 Prudent dietary pattern; CRC cis rs2949837 0.581 rs2965068 chr7:45974375 T/C cg10677697 chr7:45961126 IGFBP3 0.34 6.08 0.32 3.4e-9 Sitting height ratio; CRC cis rs2797160 1.000 rs1418951 chr6:125996185 A/G cg05901451 chr6:126070800 HEY2 -0.38 -5.96 -0.31 6.46e-9 Endometrial cancer; CRC cis rs2836974 0.533 rs418298 chr21:40536654 A/T cg06238570 chr21:40685208 BRWD1 0.76 12.14 0.56 2.92e-28 Cognitive function; CRC cis rs6896969 0.510 rs6874500 chr5:40427883 G/T cg09067459 chr5:40385259 NA -0.45 -7.83 -0.4 6.76e-14 Multiple sclerosis; CRC cis rs7666738 0.830 rs3907020 chr4:99038583 T/C cg05340658 chr4:99064831 C4orf37 0.58 9.01 0.44 1.7e-17 Colonoscopy-negative controls vs population controls; CRC cis rs2404602 0.692 rs35077207 chr15:76935306 A/G cg22467129 chr15:76604101 ETFA -0.38 -6.37 -0.33 6.46e-10 Blood metabolite levels; CRC cis rs832540 0.931 rs832534 chr5:56213672 G/A cg20203395 chr5:56204925 C5orf35 -0.41 -5.64 -0.3 3.67e-8 Coronary artery disease; CRC cis rs2404602 0.716 rs8039545 chr15:76707247 A/G cg03037974 chr15:76606532 NA 0.72 13.12 0.59 6.35e-32 Blood metabolite levels; CRC cis rs9399135 1.000 rs6569988 chr6:135352303 C/A cg24558204 chr6:135376177 HBS1L 0.49 7.58 0.39 3.48e-13 Red blood cell count; CRC cis rs10242455 0.702 rs73397447 chr7:99010949 G/T cg18809830 chr7:99032528 PTCD1 -1.08 -8.03 -0.4 1.73e-14 Blood metabolite levels; CRC cis rs2120019 1.000 rs7168680 chr15:75369212 G/A cg09165964 chr15:75287851 SCAMP5 -0.8 -12.62 -0.57 4.92e-30 Blood trace element (Zn levels); CRC cis rs7772486 0.597 rs2485631 chr6:146190077 G/C cg23711669 chr6:146136114 FBXO30 0.65 9.52 0.46 3.76e-19 Lobe attachment (rater-scored or self-reported); CRC cis rs7224685 0.774 rs8081417 chr17:3902650 T/A cg05562828 chr17:3906858 NA 0.59 9.42 0.46 8.19e-19 Type 2 diabetes; CRC trans rs10982213 0.830 rs2274163 chr9:117188714 C/T cg03352657 chr17:26684557 POLDIP2;TMEM199 0.36 6.13 0.32 2.48e-9 Interleukin-6 levels; CRC cis rs1707322 0.721 rs11211163 chr1:46153548 C/T cg06784218 chr1:46089804 CCDC17 0.66 12.38 0.56 3.81e-29 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs1552244 0.554 rs17050705 chr3:10046398 G/C cg00166722 chr3:10149974 C3orf24 0.43 6.37 0.33 6.32e-10 Alzheimer's disease; CRC trans rs66887589 0.777 rs2017058 chr4:120257739 T/C cg25214090 chr10:38739885 LOC399744 0.39 6.0 0.31 5.15e-9 Diastolic blood pressure; CRC cis rs6088813 1.000 rs1406947 chr20:33969530 C/T cg14752227 chr20:34000481 UQCC -0.37 -5.6 -0.3 4.41e-8 Height; CRC cis rs4665809 0.590 rs4665313 chr2:26415897 A/G cg04944784 chr2:26401820 FAM59B -0.85 -11.02 -0.52 2.95e-24 Gut microbiome composition (summer); CRC cis rs4975616 0.869 rs401681 chr5:1322087 C/T cg26373071 chr5:1325741 CLPTM1L 0.51 9.46 0.46 6.2800000000000005e-19 Lung cancer; CRC cis rs1997103 1.000 rs1997102 chr7:55399322 A/C cg17469321 chr7:55412551 NA -0.73 -11.59 -0.54 2.92e-26 QRS interval (sulfonylurea treatment interaction); CRC cis rs2019137 0.539 rs4849177 chr2:113982584 T/C cg07772999 chr2:113993052 PAX8;LOC440839;LOC654433 0.55 8.28 0.42 3.16e-15 Lymphocyte counts; CRC cis rs2228479 1.000 rs12596492 chr16:89957169 T/G cg06558623 chr16:89946397 TCF25 1.08 10.68 0.51 4.63e-23 Skin colour saturation; CRC cis rs10504229 0.774 rs72650880 chr8:58164727 C/T cg08219700 chr8:58056026 NA 0.51 6.14 0.32 2.39e-9 Developmental language disorder (linguistic errors); CRC cis rs7216064 0.954 rs9907491 chr17:65949993 G/A cg12091567 chr17:66097778 LOC651250 0.64 8.05 0.41 1.53e-14 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CRC cis rs72717009 0.756 rs10494359 chr1:161463876 G/C cg15358701 chr1:161410459 NA -0.67 -7.05 -0.36 1.03e-11 Rheumatoid arthritis; CRC cis rs10504229 0.683 rs7463453 chr8:58112053 A/G cg04204079 chr8:58130323 NA -0.46 -5.84 -0.31 1.22e-8 Developmental language disorder (linguistic errors); CRC cis rs736408 0.812 rs746694 chr3:52826620 C/T cg15147215 chr3:52552868 STAB1 -0.57 -8.74 -0.43 1.22e-16 Bipolar disorder; CRC cis rs2933343 0.716 rs9872706 chr3:128567105 A/G cg11901034 chr3:128598214 ACAD9 0.51 6.1 0.32 3.03e-9 IgG glycosylation; CRC cis rs9900062 0.519 rs2676293 chr17:62710461 T/C cg02598441 chr17:62777298 LOC146880 -0.53 -7.08 -0.36 9.01e-12 QT interval; CRC cis rs7772486 0.692 rs1577916 chr6:146069789 G/A cg05347473 chr6:146136440 FBXO30 -0.4 -6.02 -0.31 4.73e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs4731207 0.672 rs11983251 chr7:124459925 G/A cg23710748 chr7:124431027 NA 0.38 6.1 0.32 2.96e-9 Cutaneous malignant melanoma; CRC cis rs6951245 0.882 rs10256720 chr7:1210825 C/G cg04025307 chr7:1156635 C7orf50 0.67 7.4 0.38 1.17e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs6496044 0.963 rs6496050 chr15:86069250 A/G cg17133734 chr15:86042851 AKAP13 0.38 5.71 0.3 2.58e-8 Interstitial lung disease; CRC trans rs10488031 1.000 rs10488031 chr7:37076854 A/G cg03885431 chr1:3153144 PRDM16 -0.57 -6.11 -0.32 2.82e-9 QT interval; CRC cis rs2948294 0.566 rs13261997 chr8:8112295 C/T cg06636001 chr8:8085503 FLJ10661 0.58 7.71 0.39 1.46e-13 Red cell distribution width; CRC cis rs10751667 0.643 rs11246348 chr11:939476 G/C cg06064525 chr11:970664 AP2A2 -0.33 -6.71 -0.35 8.44e-11 Alzheimer's disease (late onset); CRC cis rs950169 0.922 rs11630507 chr15:85095725 A/G cg17507749 chr15:85114479 UBE2QP1 0.73 11.25 0.53 4.82e-25 Schizophrenia; CRC cis rs4862750 0.872 rs7658314 chr4:187900356 T/C cg27532560 chr4:187881888 NA -0.57 -10.58 -0.5 1.04e-22 Lobe attachment (rater-scored or self-reported); CRC cis rs3008870 1.000 rs12132068 chr1:67451924 G/T cg08660285 chr1:67390436 MIER1;WDR78 -1.03 -15.05 -0.64 2.59e-39 Lymphocyte percentage of white cells; CRC cis rs7727544 0.507 rs9791170 chr5:131569627 A/G cg18301423 chr5:131593218 PDLIM4 0.43 7.79 0.39 9.08e-14 Blood metabolite levels; CRC cis rs6589219 0.954 rs4520624 chr11:111172210 A/G cg25129781 chr11:111156908 C11orf53 -0.32 -5.7 -0.3 2.62e-8 Colorectal cancer; CRC cis rs2274273 0.905 rs17128183 chr14:55579513 C/T cg23234261 chr14:55582407 NA 0.29 5.74 0.3 2.14e-8 Protein biomarker; CRC cis rs17666538 0.710 rs7834337 chr8:655828 A/G cg10396713 chr8:602097 NA 0.54 6.04 0.32 4.23e-9 IgG glycosylation; CRC cis rs11252926 0.537 rs4881274 chr10:459940 G/A cg03684893 chr10:554711 DIP2C -0.34 -5.85 -0.31 1.16e-8 Psychosis in Alzheimer's disease; CRC cis rs3617 0.625 rs56019197 chr3:52874753 T/C cg18099408 chr3:52552593 STAB1 0.34 5.8 0.3 1.57e-8 Red blood cell count;Autism spectrum disorder or schizophrenia; CRC cis rs28386778 0.897 rs8067102 chr17:61848779 C/G cg06601766 chr17:61851465 DDX42;CCDC47 0.45 6.1 0.32 3.06e-9 Prudent dietary pattern; CRC cis rs6860806 0.507 rs272868 chr5:131680751 C/G cg27615366 chr5:131592974 PDLIM4 0.32 5.67 0.3 3.19e-8 Breast cancer; CRC cis rs3806843 0.868 rs2531352 chr5:140119534 A/G cg16607685 chr5:140181889 PCDHA2;PCDHA1;PCDHA3 0.25 5.91 0.31 8.73e-9 Depressive symptoms (multi-trait analysis); CRC trans rs11098499 0.730 rs78971550 chr4:120281041 C/T cg25214090 chr10:38739885 LOC399744 0.6 9.39 0.46 1.01e-18 Corneal astigmatism; CRC cis rs6942756 0.840 rs963465 chr7:128875612 C/G cg02491457 chr7:128862824 NA 0.66 9.22 0.45 3.64e-18 White matter hyperintensity burden; CRC cis rs2239547 0.657 rs6445539 chr3:52874296 G/A cg10802521 chr3:52805072 NEK4 -0.46 -6.16 -0.32 2.17e-9 Schizophrenia; CRC cis rs17376456 0.877 rs12153788 chr5:93405437 A/G cg21475434 chr5:93447410 FAM172A 0.74 7.56 0.38 4.17e-13 Diabetic retinopathy; CRC cis rs6089584 0.606 rs7270469 chr20:60577258 G/A cg23262073 chr20:60523788 NA -0.38 -6.4 -0.33 5.41e-10 Body mass index; CRC cis rs11190604 1.000 rs10883503 chr10:102275504 C/A cg07080220 chr10:102295463 HIF1AN 0.47 5.69 0.3 2.83e-8 Palmitoleic acid (16:1n-7) levels; CRC cis rs79349575 0.783 rs4399576 chr17:47009835 G/A cg00947319 chr17:47005597 UBE2Z -0.34 -5.89 -0.31 9.32e-9 Type 2 diabetes; CRC cis rs9868809 0.881 rs9878063 chr3:48678971 T/G cg00383909 chr3:49044727 WDR6 0.61 6.44 0.33 4.23e-10 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; CRC cis rs2732480 0.557 rs923397 chr12:48720392 G/A cg24011408 chr12:48396354 COL2A1 0.45 6.23 0.32 1.41e-9 Hemoglobin concentration;Red blood cell count;Hematocrit; CRC trans rs11165623 0.792 rs6593599 chr1:96911468 C/T cg10631902 chr5:14652156 NA -0.51 -9.61 -0.47 1.92e-19 Hip circumference;Waist circumference; CRC cis rs13256369 0.865 rs13282523 chr8:8577293 C/G cg06671706 chr8:8559999 CLDN23 0.54 8.22 0.41 4.76e-15 Obesity-related traits; CRC cis rs7274811 0.652 rs291694 chr20:32000351 A/G cg07470512 chr20:32255052 NECAB3;C20orf134 0.44 5.8 0.3 1.56e-8 Height; CRC cis rs6963495 0.818 rs17343556 chr7:105151272 C/T cg13798780 chr7:105162888 PUS7 0.67 7.93 0.4 3.42e-14 Bipolar disorder (body mass index interaction); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg22643867 chr2:131148877 NA 0.41 6.24 0.33 1.34e-9 Intelligence (multi-trait analysis); CRC cis rs477692 1.000 rs485576 chr10:131425496 G/C cg26102564 chr10:131424627 MGMT 0.38 5.67 0.3 3.05e-8 Response to temozolomide; CRC cis rs12476592 0.602 rs262516 chr2:63891212 T/G cg10828910 chr2:63850056 LOC388955 0.47 5.65 0.3 3.49e-8 Childhood ear infection; CRC cis rs10504229 0.593 rs11781042 chr8:57993056 A/T cg02725872 chr8:58115012 NA -0.44 -6.51 -0.34 2.78e-10 Developmental language disorder (linguistic errors); CRC cis rs1218582 0.661 rs4845695 chr1:154911798 A/G cg24250549 chr1:154909240 PMVK 0.58 8.59 0.43 3.57e-16 Prostate cancer; CRC cis rs4713118 0.955 rs9368529 chr6:27684631 G/A cg15845792 chr6:28175446 NA 0.6 7.9 0.4 4.36e-14 Parkinson's disease; CRC trans rs6951245 0.935 rs11763765 chr7:1060510 C/T cg13565492 chr6:43139072 SRF -0.71 -7.3 -0.37 2.13e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC trans rs875971 0.660 rs2191268 chr7:66110224 C/T cg22194305 chr4:2264032 MXD4 -0.38 -5.98 -0.31 5.81e-9 Aortic root size; CRC cis rs7312933 0.558 rs11181507 chr12:42844763 T/A cg11827402 chr12:42719852 PPHLN1;ZCRB1 0.65 9.31 0.46 1.86e-18 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CRC cis rs7044106 0.664 rs7861679 chr9:123375589 A/G cg14255062 chr9:123606675 PSMD5;LOC253039 -0.38 -5.86 -0.31 1.14e-8 Hip circumference adjusted for BMI; CRC cis rs826838 0.904 rs10880981 chr12:38763911 G/A cg13010199 chr12:38710504 ALG10B 0.46 6.02 0.32 4.65e-9 Heart rate; CRC cis rs7917772 0.582 rs7906115 chr10:104327164 A/G cg11453585 chr10:104263688 ACTR1A;SUFU 0.82 15.26 0.64 3.8e-40 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC cis rs116095464 0.558 rs9688045 chr5:254035 T/C cg22496380 chr5:211416 CCDC127 -0.91 -10.46 -0.5 2.65e-22 Breast cancer; CRC cis rs11098499 0.863 rs13136462 chr4:120543173 C/T cg24375607 chr4:120327624 NA 0.53 7.89 0.4 4.65e-14 Corneal astigmatism; CRC cis rs2576037 0.901 rs6507719 chr18:44581310 A/T cg19077165 chr18:44547161 KATNAL2 0.48 7.61 0.39 3e-13 Personality dimensions; CRC cis rs704795 0.775 rs4665975 chr2:27626017 A/T cg27432699 chr2:27873401 GPN1 -0.6 -8.85 -0.44 5.36e-17 Menopause (age at onset); CRC cis rs7208859 0.573 rs73267873 chr17:29068457 C/T cg01831904 chr17:28903510 LRRC37B2 -0.56 -6.37 -0.33 6.29e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC trans rs875971 0.660 rs2191268 chr7:66110224 C/T cg25754248 chr19:5123156 KDM4B 0.36 6.4 0.33 5.23e-10 Aortic root size; CRC cis rs9303280 0.776 rs11078926 chr17:38062976 G/A cg11212589 chr17:38028394 ZPBP2 0.43 7.71 0.39 1.55e-13 Self-reported allergy; CRC cis rs73206853 0.534 rs73205062 chr12:110511136 G/C cg12870014 chr12:110450643 ANKRD13A 0.86 8.87 0.44 4.74e-17 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC cis rs2580764 0.515 rs7570629 chr2:55255935 A/T cg09592903 chr2:55203963 RTN4 -0.7 -11.28 -0.53 3.54e-25 Mean platelet volume; CRC cis rs73206853 0.609 rs55833146 chr12:110872335 A/G cg12870014 chr12:110450643 ANKRD13A 0.82 9.8 0.48 4.76e-20 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC cis rs2836974 0.831 rs2836921 chr21:40516070 C/T cg11890956 chr21:40555474 PSMG1 0.98 15.21 0.64 6.1e-40 Cognitive function; CRC cis rs7618915 0.547 rs13064064 chr3:52657002 T/C cg11645453 chr3:52864694 ITIH4 0.35 6.2 0.32 1.73e-9 Bipolar disorder; CRC cis rs9487051 0.872 rs1111863 chr6:109611206 C/T cg12927641 chr6:109611667 NA 0.38 6.87 0.35 3.26e-11 Reticulocyte fraction of red cells; CRC cis rs2576037 0.901 rs2571021 chr18:44583498 A/G cg20875182 chr18:44561130 TCEB3B;KATNAL2 -0.47 -7.81 -0.4 7.93e-14 Personality dimensions; CRC cis rs1862618 0.853 rs832583 chr5:56178217 A/C cg22800045 chr5:56110881 MAP3K1 0.62 6.64 0.34 1.29e-10 Initial pursuit acceleration; CRC cis rs73206853 0.686 rs56339227 chr12:111164963 T/C cg12870014 chr12:110450643 ANKRD13A 0.75 8.89 0.44 4.07e-17 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC cis rs7552404 1.000 rs4559448 chr1:76203456 A/G cg03433033 chr1:76189801 ACADM 0.79 10.76 0.51 2.39e-23 Blood metabolite levels;Acylcarnitine levels; CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg11317019 chr17:42219250 C17orf53 -0.49 -5.98 -0.31 5.84e-9 Diisocyanate-induced asthma; CRC cis rs1799949 1.000 rs2070834 chr17:41242285 T/G cg01879757 chr17:41196368 BRCA1 -0.42 -6.32 -0.33 8.39e-10 Menopause (age at onset); CRC trans rs2303319 0.504 rs62188988 chr2:162531068 T/C cg22677401 chr17:46026860 NA -0.66 -6.04 -0.32 4.28e-9 Cognitive function; CRC cis rs7412746 0.611 rs7556661 chr1:150892009 C/T cg15448220 chr1:150897856 SETDB1 0.56 8.17 0.41 6.67e-15 Melanoma; CRC cis rs13108904 0.935 rs1732100 chr4:1281761 C/T cg23123621 chr4:1343375 KIAA1530 -0.34 -6.11 -0.32 2.77e-9 Obesity-related traits; CRC cis rs77106637 0.860 rs75896506 chr11:72429579 G/A cg03713592 chr11:72463424 ARAP1 1.15 11.19 0.53 7.45e-25 Type 2 diabetes; CRC cis rs853679 0.574 rs1233705 chr6:28166447 C/G cg02683197 chr6:28174875 NA 0.88 12.35 0.56 4.59e-29 Depression; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg07806421 chr2:139259153 SPOPL 0.44 6.46 0.34 3.68e-10 Intelligence (multi-trait analysis); CRC cis rs8180040 0.764 rs13062022 chr3:47169375 G/A cg02527881 chr3:46936655 PTH1R -0.4 -7.44 -0.38 8.91e-13 Colorectal cancer; CRC cis rs3790645 0.831 rs873151 chr1:26880989 T/C cg17456097 chr1:26900765 RPS6KA1 0.39 5.63 0.3 3.93e-8 Glucose homeostasis traits; CRC cis rs832540 0.629 rs3309 chr5:56092779 A/T cg24531977 chr5:56204891 C5orf35 0.5 7.7 0.39 1.58e-13 Coronary artery disease; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg14258675 chr14:75348443 DLST 0.43 6.16 0.32 2.15e-9 Response to antipsychotic treatment; CRC cis rs3741404 0.825 rs2515241 chr11:63975331 C/T cg06219103 chr11:63990595 FERMT3 -0.4 -6.14 -0.32 2.42e-9 Platelet count; CRC cis rs10463316 0.962 rs61647401 chr5:150743076 T/C cg03212797 chr5:150827313 SLC36A1 -0.41 -6.01 -0.31 4.84e-9 Metabolite levels (Pyroglutamine); CRC trans rs875971 0.660 rs2191268 chr7:66110224 C/T cg23261184 chr5:159866303 NA -0.41 -6.42 -0.33 4.68e-10 Aortic root size; CRC cis rs763121 0.888 rs2235229 chr22:39124912 A/G cg06022373 chr22:39101656 GTPBP1 0.67 10.38 0.5 4.97e-22 Menopause (age at onset); CRC cis rs4629180 1.000 rs974374 chr2:102105846 C/T cg04415270 chr2:102091202 RFX8 0.56 7.78 0.39 9.25e-14 Chronic rhinosinusitis with nasal polyps; CRC cis rs3741404 0.594 rs11231704 chr11:63898182 C/T cg06243084 chr11:63990629 FERMT3 0.39 5.95 0.31 6.99e-9 Platelet count; CRC cis rs9894429 0.608 rs7406219 chr17:79609410 G/T cg18240062 chr17:79603768 NPLOC4 0.48 7.55 0.38 4.24e-13 Eye color traits; CRC cis rs7945705 0.840 rs10840136 chr11:8885024 C/T cg21881798 chr11:8931708 C11orf17;ST5 -0.73 -12.88 -0.58 5.02e-31 Hemoglobin concentration; CRC cis rs6570726 0.905 rs442435 chr6:145815559 C/T cg23711669 chr6:146136114 FBXO30 0.62 10.62 0.51 7.79e-23 Lobe attachment (rater-scored or self-reported); CRC cis rs4363385 0.747 rs4478766 chr1:152984906 G/A cg25856811 chr1:152973957 SPRR3 -0.25 -6.91 -0.36 2.54e-11 Inflammatory skin disease; CRC cis rs12477438 0.834 rs6757019 chr2:99676936 T/A cg26064155 chr2:99771622 LIPT1;TSGA10 -0.79 -11.26 -0.53 4.44e-25 Chronic sinus infection; CRC cis rs798554 0.836 rs13243214 chr7:2817455 G/T cg17321639 chr7:2759063 NA -0.51 -6.77 -0.35 6.05e-11 Height; CRC cis rs1018836 0.892 rs4735210 chr8:91549399 G/T cg16814680 chr8:91681699 NA -0.64 -10.16 -0.49 2.86e-21 Ejection fraction in Tripanosoma cruzi seropositivity; CRC cis rs9462027 0.727 rs3798352 chr6:34734809 T/A cg07306190 chr6:34760872 UHRF1BP1 -0.35 -6.25 -0.33 1.28e-9 Systemic lupus erythematosus; CRC cis rs4074961 0.544 rs11264067 chr1:37991458 C/T cg13401533 chr1:37979913 MEAF6 0.43 6.08 0.32 3.29e-9 Axial length; CRC cis rs947211 1.000 rs947211 chr1:205752665 A/G cg11965913 chr1:205819406 PM20D1 0.45 6.42 0.33 4.77e-10 Parkinson's disease; CRC cis rs9311474 0.581 rs13621 chr3:52558133 T/C cg08222913 chr3:52553049 STAB1 -0.36 -6.91 -0.36 2.44e-11 Electroencephalogram traits; CRC cis rs9858542 0.953 rs11710037 chr3:49675334 C/G cg03060546 chr3:49711283 APEH -0.52 -7.01 -0.36 1.32e-11 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs10876993 0.928 rs1678532 chr12:58055197 T/G cg15848620 chr12:58087721 OS9 -0.65 -8.94 -0.44 2.88e-17 Celiac disease or Rheumatoid arthritis; CRC cis rs2836974 0.584 rs6517535 chr21:40653352 G/C cg22974920 chr21:40686053 BRWD1 -0.43 -5.94 -0.31 7.38e-9 Cognitive function; CRC cis rs720844 0.535 rs12997838 chr2:149284931 C/G cg09247360 chr2:149335327 NA -0.55 -5.78 -0.3 1.76e-8 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs2742417 1.000 rs1877932 chr3:45753539 A/G cg04837898 chr3:45731254 SACM1L -0.36 -5.92 -0.31 7.95e-9 Response to anti-depressant treatment in major depressive disorder; CRC cis rs9323205 0.911 rs12587611 chr14:51641399 C/T cg23942311 chr14:51606299 NA -0.59 -8.2 -0.41 5.52e-15 Cancer; CRC cis rs1559088 0.948 rs9304844 chr19:33579935 G/T cg03563238 chr19:33554763 RHPN2 -0.31 -5.63 -0.3 3.87e-8 Bone ultrasound measurement (broadband ultrasound attenuation); CRC cis rs6585424 1.000 rs61860024 chr10:81925363 G/A cg11900509 chr10:81946545 ANXA11 -0.76 -9.32 -0.46 1.78e-18 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs947583 0.913 rs2027516 chr6:136131888 C/T cg06563441 chr6:136217110 PDE7B 0.33 5.6 0.3 4.46e-8 Phosphorus levels; CRC cis rs11676348 0.783 rs4674252 chr2:218984478 G/A cg00012203 chr2:219082015 ARPC2 -0.44 -6.47 -0.34 3.53e-10 Ulcerative colitis; CRC cis rs738322 0.600 rs6001035 chr22:38562425 A/G cg25457927 chr22:38595422 NA -0.33 -6.73 -0.35 7.77e-11 Cutaneous nevi; CRC cis rs1728785 0.901 rs3087783 chr16:68599668 C/T cg02972257 chr16:68554789 NA -0.66 -7.8 -0.39 8.36e-14 Ulcerative colitis; CRC cis rs853679 0.517 rs9380049 chr6:28048535 A/G cg21251018 chr6:28226885 NKAPL 0.47 6.16 0.32 2.07e-9 Depression; CRC cis rs9325144 0.671 rs35817541 chr12:38975001 T/C cg26384229 chr12:38710491 ALG10B -0.52 -7.44 -0.38 8.91e-13 Morning vs. evening chronotype; CRC cis rs6860806 0.695 rs11952099 chr5:131576772 A/G cg18758796 chr5:131593413 PDLIM4 0.46 8.57 0.43 4.01e-16 Breast cancer; CRC cis rs17711722 0.701 rs55773927 chr7:65337902 T/C cg18912574 chr7:65842487 NCRNA00174 0.33 5.66 0.3 3.37e-8 Calcium levels; CRC cis rs7264396 0.563 rs6060560 chr20:34278890 T/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.43 -5.71 -0.3 2.52e-8 Total cholesterol levels; CRC cis rs651907 0.557 rs11917569 chr3:101355063 G/C cg11279151 chr3:101281821 RG9MTD1 -0.56 -7.67 -0.39 1.9e-13 Colorectal cancer; CRC cis rs7945705 0.905 rs2568054 chr11:8876029 A/G cg21881798 chr11:8931708 C11orf17;ST5 -0.73 -12.27 -0.56 9.14e-29 Hemoglobin concentration; CRC cis rs6912958 0.781 rs9450755 chr6:88303702 T/C cg12350822 chr6:88032061 C6orf162;GJB7 -0.34 -6.38 -0.33 5.94e-10 Monocyte percentage of white cells; CRC cis rs7512552 0.839 rs1694385 chr1:150377960 G/A cg15654264 chr1:150340011 RPRD2 0.59 8.6 0.43 3.4e-16 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); CRC trans rs61931739 0.500 rs12146843 chr12:34451738 T/G cg13010199 chr12:38710504 ALG10B 0.46 6.5 0.34 2.99e-10 Morning vs. evening chronotype; CRC cis rs10504229 0.683 rs11774585 chr8:58132685 G/A cg02290350 chr8:58132656 NA -0.58 -8.16 -0.41 7.29e-15 Developmental language disorder (linguistic errors); CRC cis rs9549367 0.789 rs12866090 chr13:113869410 G/A cg00898013 chr13:113819073 PROZ -0.42 -6.09 -0.32 3.17e-9 Platelet distribution width; CRC cis rs270601 0.710 rs4705852 chr5:131602807 A/G cg12564285 chr5:131593104 PDLIM4 0.54 10.42 0.5 3.71e-22 Acylcarnitine levels; CRC cis rs559928 0.556 rs11607903 chr11:63932140 G/A cg19465662 chr11:63993652 NUDT22;TRPT1 0.7 6.67 0.34 1.11e-10 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; CRC trans rs2303319 0.504 rs1006428 chr2:162592559 A/C cg22988483 chr14:93581567 ITPK1 -0.66 -6.07 -0.32 3.52e-9 Cognitive function; CRC cis rs1218582 0.741 rs11264281 chr1:154867221 A/G cg24250549 chr1:154909240 PMVK 0.58 9.1 0.45 9.19e-18 Prostate cancer; CRC cis rs1153858 1.000 rs3759899 chr15:45655903 T/C cg10760299 chr15:45669010 GATM 0.51 8.14 0.41 8.08e-15 Homoarginine levels; CRC cis rs9818758 0.545 rs9853352 chr3:49813258 C/T cg07636037 chr3:49044803 WDR6 0.72 5.7 0.3 2.61e-8 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; CRC cis rs17152411 1.000 rs11245423 chr10:126588435 C/A cg07906193 chr10:126599966 NA 0.57 6.47 0.34 3.61e-10 Height; CRC cis rs8060686 0.641 rs57408712 chr16:68242573 G/C cg26727032 chr16:67993705 SLC12A4 -0.54 -6.61 -0.34 1.56e-10 HDL cholesterol;Metabolic syndrome; CRC cis rs3771570 0.901 rs3771587 chr2:242409701 A/G cg21155796 chr2:242212141 HDLBP 0.63 6.8 0.35 5.04e-11 Prostate cancer; CRC cis rs394563 0.591 rs237012 chr6:149729198 T/C cg11245181 chr6:149772854 ZC3H12D -0.53 -9.29 -0.46 2.23e-18 Dupuytren's disease; CRC cis rs3008870 1.000 rs2755245 chr1:67487964 C/G cg08660285 chr1:67390436 MIER1;WDR78 1.02 14.52 0.62 2.93e-37 Lymphocyte percentage of white cells; CRC cis rs2439831 0.850 rs3816792 chr15:44116986 A/G cg02155558 chr15:43621948 ADAL;LCMT2 -0.7 -7.87 -0.4 5.32e-14 Lung cancer in ever smokers; CRC cis rs57221529 0.709 rs72703090 chr5:598314 C/T cg16447950 chr5:562315 NA -0.73 -9.65 -0.47 1.41e-19 Lung disease severity in cystic fibrosis; CRC cis rs12451471 0.620 rs11150846 chr17:78098520 C/T cg18972013 chr17:78078605 GAA -0.41 -6.03 -0.32 4.41e-9 Plateletcrit;Mean corpuscular hemoglobin concentration; CRC cis rs13108904 0.901 rs12641735 chr4:1304434 G/C cg21620606 chr4:1342894 KIAA1530 0.33 5.6 0.3 4.47e-8 Obesity-related traits; CRC trans rs11098499 0.863 rs7678400 chr4:120461957 G/A cg25214090 chr10:38739885 LOC399744 0.65 10.46 0.5 2.74e-22 Corneal astigmatism; CRC cis rs9583531 0.600 rs9555726 chr13:111368316 C/T cg24331049 chr13:111365604 ING1 0.55 7.62 0.39 2.7e-13 Coronary artery disease; CRC cis rs6835098 0.692 rs6822683 chr4:174063974 G/A cg08422745 chr4:174089978 GALNT7 -0.77 -11.78 -0.54 5.83e-27 Dementia and core Alzheimer's disease neuropathologic changes; CRC cis rs7209700 0.547 rs11649785 chr17:45355720 G/A cg08085267 chr17:45401833 C17orf57 0.54 6.4 0.33 5.22e-10 IgG glycosylation; CRC cis rs1552244 1.000 rs113153120 chr3:10156398 G/A cg10729496 chr3:10149963 C3orf24 0.54 6.97 0.36 1.71e-11 Alzheimer's disease; CRC cis rs4363385 0.818 rs4845522 chr1:153011099 C/T cg25856811 chr1:152973957 SPRR3 -0.25 -6.99 -0.36 1.51e-11 Inflammatory skin disease; CRC cis rs644799 1.000 rs543530 chr11:95545170 A/G cg03916912 chr11:95522834 CEP57;FAM76B 0.95 18.15 0.71 1.71e-51 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs1862618 0.853 rs6885541 chr5:56110857 G/C cg12311346 chr5:56204834 C5orf35 -0.8 -10.34 -0.5 6.98e-22 Initial pursuit acceleration; CRC trans rs10139154 0.824 rs183467 chr14:31009261 A/T cg18753625 chr19:36705707 ZNF565;ZNF146 -0.45 -6.51 -0.34 2.84e-10 Amyotrophic lateral sclerosis; CRC cis rs7666738 0.800 rs11941885 chr4:99072921 A/C cg05340658 chr4:99064831 C4orf37 0.59 9.2 0.45 4.27e-18 Colonoscopy-negative controls vs population controls; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg20623943 chr1:47799834 CMPK1 0.47 6.04 0.32 4.08e-9 Thyroid stimulating hormone; CRC cis rs6582630 0.519 rs1851121 chr12:38389467 T/C cg26384229 chr12:38710491 ALG10B 0.69 9.77 0.47 5.95e-20 Drug-induced liver injury (flucloxacillin); CRC trans rs7301826 0.627 rs7315707 chr12:131272819 A/G cg07817097 chr1:179851575 TOR1AIP1 0.47 5.97 0.31 6e-9 Plasma plasminogen activator levels; CRC cis rs3790645 0.645 rs3790644 chr1:26884676 G/A cg17456097 chr1:26900765 RPS6KA1 0.47 6.08 0.32 3.39e-9 Glucose homeostasis traits; CRC cis rs6502050 0.805 rs7406137 chr17:80084465 T/C cg09264619 chr17:80180166 NA 0.35 5.8 0.3 1.55e-8 Life satisfaction; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg02956093 chr14:105261335 AKT1 0.49 6.34 0.33 7.5e-10 Thyroid stimulating hormone; CRC cis rs17376456 0.825 rs10064368 chr5:93266396 C/A cg25358565 chr5:93447407 FAM172A 1.1 10.9 0.52 7.71e-24 Diabetic retinopathy; CRC cis rs72717009 0.825 rs11810143 chr1:161480649 A/G cg15358701 chr1:161410459 NA -0.58 -5.99 -0.31 5.55e-9 Rheumatoid arthritis; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg04294625 chr17:45727224 KPNB1 0.49 6.5 0.34 2.93e-10 Anxiety disorder; CRC cis rs501120 0.925 rs1746050 chr10:44777188 C/A cg09554077 chr10:44749378 NA 0.74 11.03 0.52 2.74e-24 Coronary artery disease;Coronary heart disease; CRC cis rs2274273 0.624 rs11158034 chr14:55753560 C/T cg10130446 chr14:55658398 DLGAP5 -0.4 -5.7 -0.3 2.65e-8 Protein biomarker; CRC cis rs10484885 0.680 rs72921943 chr6:90581542 A/C cg13799429 chr6:90582589 CASP8AP2 -0.83 -12.7 -0.57 2.5e-30 QRS interval (sulfonylurea treatment interaction); CRC cis rs9372498 0.536 rs9489407 chr6:118792337 A/T cg18833306 chr6:118973337 C6orf204 -0.46 -6.22 -0.32 1.55e-9 Diastolic blood pressure; CRC cis rs2739330 0.760 rs1002286 chr22:24257337 A/G cg10150615 chr22:24372951 LOC391322 0.56 8.69 0.43 1.68e-16 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs7666738 0.830 rs35491210 chr4:99003364 T/C cg17366294 chr4:99064904 C4orf37 0.43 7.27 0.37 2.66e-12 Colonoscopy-negative controls vs population controls; CRC cis rs6076065 0.723 rs6137949 chr20:23418217 T/G cg11657817 chr20:23433608 CST11 0.44 6.34 0.33 7.68e-10 Facial morphology (factor 15, philtrum width); CRC cis rs6860806 0.531 rs2631359 chr5:131707892 C/T cg18301423 chr5:131593218 PDLIM4 -0.39 -6.46 -0.34 3.66e-10 Breast cancer; CRC trans rs12744310 0.887 rs35464028 chr1:41800474 T/G cg19175123 chr10:103411746 FBXW4 0.46 6.11 0.32 2.75e-9 Cognitive ability (multi-trait analysis);Intelligence;Cognitive ability; CRC cis rs1552244 1.000 rs57631744 chr3:10118962 T/C cg00166722 chr3:10149974 C3orf24 0.67 9.26 0.45 2.71e-18 Alzheimer's disease; CRC trans rs11098499 0.863 rs36040693 chr4:120477616 A/G cg25214090 chr10:38739885 LOC399744 0.66 10.39 0.5 4.71e-22 Corneal astigmatism; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg15586420 chr15:90294517 MESP1 0.48 6.25 0.33 1.28e-9 Thyroid stimulating hormone; CRC cis rs6976053 0.518 rs314357 chr7:100410069 A/G cg20848291 chr7:100343083 ZAN 0.4 6.07 0.32 3.48e-9 Plasminogen activator inhibitor type 1 levels (PAI-1); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg19922493 chr2:176045768 ATP5G3 0.46 6.88 0.35 3.11e-11 Intelligence (multi-trait analysis); CRC trans rs2553218 0.690 rs8032415 chr15:54851945 A/G cg05622764 chr5:72744675 FOXD1 0.48 6.51 0.34 2.86e-10 Immune response to smallpox vaccine (IL-6); CRC cis rs6586163 0.527 rs3740286 chr10:90751340 A/G cg13456138 chr10:90753195 FAS 0.42 5.94 0.31 7.22e-9 Chronic lymphocytic leukemia; CRC cis rs4648845 0.579 rs4592207 chr1:2369498 A/G cg13556452 chr1:2391241 NA -0.35 -5.92 -0.31 7.97e-9 Schizophrenia; CRC cis rs9612 0.950 rs346546 chr19:44256910 T/C cg08581076 chr19:44259116 C19orf61 0.47 6.13 0.32 2.52e-9 Exhaled nitric oxide output; CRC cis rs1005277 0.505 rs200935 chr10:38132810 T/A cg25517755 chr10:38738941 LOC399744 -0.44 -6.48 -0.34 3.36e-10 Extrinsic epigenetic age acceleration; CRC cis rs4285028 0.747 rs9824235 chr3:121432177 G/T cg20356878 chr3:121714668 ILDR1 -0.42 -5.97 -0.31 6.25e-9 Multiple sclerosis; CRC cis rs3809863 0.602 rs2317677 chr17:45393407 G/A cg25173405 chr17:45401733 C17orf57 -0.65 -10.18 -0.49 2.4e-21 Glaucoma (primary open-angle); CRC cis rs28386778 0.724 rs35092235 chr17:61944621 T/C cg25654072 chr17:61904446 PSMC5;FTSJ3 0.71 10.92 0.52 6.75e-24 Prudent dietary pattern; CRC cis rs898097 0.812 rs8065641 chr17:80820259 A/G cg03160526 chr17:80928410 B3GNTL1 -0.42 -6.26 -0.33 1.23e-9 Breast cancer; CRC cis rs7246657 0.943 rs7252325 chr19:37930645 A/G cg23950597 chr19:37808831 NA -0.52 -6.34 -0.33 7.48e-10 Coronary artery calcification; CRC cis rs9487051 0.639 rs2884012 chr6:109598221 C/T cg21918786 chr6:109611834 NA -0.41 -7.17 -0.37 4.84e-12 Reticulocyte fraction of red cells; CRC cis rs12711979 0.765 rs7559461 chr2:3818623 G/A cg17052675 chr2:3827356 NA -0.55 -10.42 -0.5 3.73e-22 Itch intensity from mosquito bite adjusted by bite size; CRC cis rs736408 0.609 rs2268025 chr3:52795224 A/T cg07507251 chr3:52567010 NT5DC2 0.45 6.37 0.33 6.43e-10 Bipolar disorder; CRC cis rs6502050 0.731 rs34796376 chr17:80116635 G/T cg22110888 chr17:80059540 CCDC57 0.41 6.5 0.34 2.95e-10 Life satisfaction; CRC cis rs995000 0.931 rs12037659 chr1:62923863 C/T cg19896129 chr1:63156450 NA 0.4 5.78 0.3 1.76e-8 Triglyceride levels; CRC cis rs9649213 0.593 rs34129434 chr7:97926464 C/T cg00277769 chr7:97922759 BAIAP2L1 -0.61 -10.74 -0.51 2.82e-23 Prostate cancer (SNP x SNP interaction); CRC cis rs13315871 0.929 rs11716580 chr3:58228695 G/C cg20936604 chr3:58311152 NA -0.72 -6.63 -0.34 1.41e-10 Cholesterol, total; CRC cis rs11229555 0.645 rs11229459 chr11:58208025 G/A cg15696309 chr11:58395628 NA -0.82 -10.45 -0.5 2.81e-22 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; CRC cis rs12541335 0.639 rs13257108 chr8:22165043 T/C cg09517075 chr8:22133004 PIWIL2 0.47 8.28 0.42 3.18e-15 Hypertriglyceridemia; CRC cis rs853679 0.769 rs7752608 chr6:28301195 A/G cg15845792 chr6:28175446 NA 0.8 6.5 0.34 3.02e-10 Depression; CRC cis rs2153535 0.580 rs4960413 chr6:8438466 C/T cg21535247 chr6:8435926 SLC35B3 0.48 7.26 0.37 2.78e-12 Motion sickness; CRC cis rs7312774 0.748 rs10492211 chr12:107298213 T/C cg16260113 chr12:107380972 MTERFD3 0.78 7.76 0.39 1.11e-13 Severe influenza A (H1N1) infection; CRC cis rs3733585 0.673 rs4311316 chr4:9955971 A/C cg11266682 chr4:10021025 SLC2A9 0.46 9.19 0.45 4.4e-18 Cleft plate (environmental tobacco smoke interaction); CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg05139649 chr11:108368923 KDELC2 -0.41 -6.17 -0.32 1.95e-9 Myopia (pathological); CRC trans rs4295623 0.585 rs13259242 chr8:11593033 T/G cg06636001 chr8:8085503 FLJ10661 -0.55 -8.26 -0.41 3.58e-15 Morning vs. evening chronotype; CRC cis rs4242434 0.927 rs3736147 chr8:22471824 A/G cg03733263 chr8:22462867 KIAA1967 -1.05 -18.99 -0.72 8.42e-55 Exploratory eye movement dysfunction in schizophrenia (cognitive search score); CRC cis rs4664304 0.934 rs72957586 chr2:160762687 G/A cg03641300 chr2:160917029 PLA2R1 -0.42 -5.9 -0.31 9.08e-9 Crohn's disease;Inflammatory bowel disease; CRC trans rs7615952 0.546 rs2979340 chr3:125341384 C/T cg02560186 chr11:3602584 NA -0.56 -6.98 -0.36 1.63e-11 Blood pressure (smoking interaction); CRC cis rs3741404 0.620 rs11231722 chr11:63967770 C/G cg14078730 chr11:63896557 MACROD1 0.35 5.73 0.3 2.21e-8 Platelet count; CRC cis rs9309711 0.666 rs6723101 chr2:3484443 T/C cg15541040 chr2:3486749 NA -0.52 -8.29 -0.42 2.83e-15 Neurofibrillary tangles; CRC cis rs344364 0.511 rs1742463 chr16:1946110 A/G cg03013636 chr16:1946785 NA 0.57 6.99 0.36 1.54e-11 Glomerular filtration rate in chronic kidney disease; CRC cis rs2859741 0.608 rs532719 chr1:37477380 C/T cg09363841 chr1:37513479 NA 0.53 8.94 0.44 2.86e-17 Forced expiratory volume in 1 second (environmental tobacco smoke interaction); CRC cis rs6912958 0.781 rs9450752 chr6:88300013 A/G cg08069147 chr6:88032118 GJB7;C6orf162 -0.57 -8.57 -0.43 4.19e-16 Monocyte percentage of white cells; CRC cis rs11098499 0.779 rs10857066 chr4:120286596 C/T cg09307838 chr4:120376055 NA 0.68 10.52 0.5 1.62e-22 Corneal astigmatism; CRC cis rs7811142 1.000 rs2897358 chr7:100088640 C/G cg00814883 chr7:100076585 TSC22D4 -0.74 -9.34 -0.46 1.46e-18 Platelet count; CRC cis rs2239547 0.522 rs9842974 chr3:53011050 C/A cg05573699 chr3:52720067 GNL3;PBRM1 -0.42 -5.66 -0.3 3.35e-8 Schizophrenia; CRC cis rs62064224 0.593 rs916663 chr17:30835833 A/C cg21839984 chr17:30846986 MYO1D 0.47 7.56 0.38 3.99e-13 Schizophrenia; CRC cis rs4478858 0.684 rs10753245 chr1:31731208 A/G cg00250761 chr1:31883323 NA -0.43 -8.47 -0.42 8.28e-16 Alcohol dependence; CRC cis rs4380275 1.000 rs4450634 chr2:773257 G/A cg27237671 chr2:676223 TMEM18 -0.43 -6.11 -0.32 2.76e-9 Adverse response to chemotherapy (neutropenia/leucopenia) (doxorubicin); CRC cis rs11677416 1.000 rs3783555 chr2:113531093 T/C cg06156847 chr2:113672199 IL1F7 -0.38 -5.67 -0.3 3.13e-8 Response to antipsychotic treatment in schizophrenia (working memory); CRC cis rs9488822 0.636 rs6937104 chr6:116375302 A/G cg05304507 chr6:116381966 FRK 0.31 8.56 0.43 4.29e-16 Cholesterol, total;LDL cholesterol; CRC cis rs9733 0.519 rs7511673 chr1:150707636 A/T cg17724175 chr1:150552817 MCL1 0.58 9.16 0.45 5.58e-18 Tonsillectomy; CRC cis rs782590 0.837 rs782573 chr2:55912961 T/C cg18811423 chr2:55921094 PNPT1 0.88 17.33 0.69 2.92e-48 Metabolic syndrome; CRC cis rs11577318 0.812 rs3795683 chr1:26632831 C/A cg00852783 chr1:26633632 UBXN11 0.47 6.76 0.35 6.21e-11 Granulocyte percentage of myeloid white cells; CRC cis rs853679 0.517 rs35193936 chr6:28076270 A/G cg23161317 chr6:28129485 ZNF389 0.52 6.38 0.33 6.1e-10 Depression; CRC cis rs6951245 1.000 rs78185801 chr7:1096367 G/A cg24642844 chr7:1081250 C7orf50 -0.78 -9.44 -0.46 7.23e-19 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs12612619 0.704 rs6754356 chr2:27315021 G/A cg00617064 chr2:27272375 NA -0.37 -6.03 -0.32 4.31e-9 Venous thromboembolism adjusted for sickle cell variant rs77121243-T; CRC cis rs1153858 1.000 rs67831559 chr15:45649307 G/T cg14582100 chr15:45693742 SPATA5L1 0.28 5.8 0.3 1.52e-8 Homoarginine levels; CRC cis rs2120019 1.000 rs7168680 chr15:75369212 G/A cg11632617 chr15:75315747 PPCDC -0.56 -7.96 -0.4 2.86e-14 Blood trace element (Zn levels); CRC cis rs6694672 1.000 rs1794003 chr1:197024643 G/A cg13682187 chr1:196946512 CFHR5 0.43 6.92 0.36 2.35e-11 Asthma; CRC cis rs11098499 0.863 rs34868248 chr4:120442430 A/G cg24375607 chr4:120327624 NA 0.47 7.17 0.37 4.89e-12 Corneal astigmatism; CRC cis rs734999 0.566 rs4648658 chr1:2560882 G/A cg18854424 chr1:2615690 NA -0.48 -9.5 -0.46 4.44e-19 Ulcerative colitis; CRC trans rs1814175 0.645 rs1721996 chr11:49915527 G/A cg11707556 chr5:10655725 ANKRD33B -0.52 -9.95 -0.48 1.49e-20 Height; CRC cis rs10504229 1.000 rs73607874 chr8:58173433 G/C cg02290350 chr8:58132656 NA -0.42 -5.96 -0.31 6.62e-9 Developmental language disorder (linguistic errors); CRC cis rs7568458 0.660 rs6722691 chr2:85758352 C/T cg02493740 chr2:85810744 VAMP5 -0.5 -7.62 -0.39 2.69e-13 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); CRC cis rs7666738 0.830 rs4502686 chr4:98765117 T/C cg05340658 chr4:99064831 C4orf37 0.54 8.0 0.4 2.21e-14 Colonoscopy-negative controls vs population controls; CRC cis rs7493 1.000 rs3735586 chr7:95035582 A/T cg17330251 chr7:94953956 PON1 -0.56 -7.33 -0.37 1.8e-12 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs73206853 0.764 rs28362526 chr12:110561779 C/A cg12870014 chr12:110450643 ANKRD13A 0.82 10.56 0.5 1.21e-22 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC cis rs67311347 1.000 rs9848083 chr3:40466979 A/G cg09455208 chr3:40491958 NA -0.44 -9.14 -0.45 6.68e-18 Renal cell carcinoma; CRC cis rs6762 0.748 rs7929032 chr11:839078 G/A cg03116740 chr11:841335 TSPAN4;POLR2L -0.42 -7.12 -0.37 6.62e-12 Mean platelet volume; CRC cis rs7666738 0.753 rs13120995 chr4:98972762 A/G cg05340658 chr4:99064831 C4orf37 0.6 9.35 0.46 1.41e-18 Colonoscopy-negative controls vs population controls; CRC cis rs4665809 0.941 rs41285975 chr2:26351144 T/C cg27170947 chr2:26402098 FAM59B -0.46 -6.1 -0.32 2.93e-9 Gut microbiome composition (summer); CRC cis rs10911363 0.549 rs2794619 chr1:183459670 G/A cg09173681 chr1:183549694 NCF2 0.73 9.97 0.48 1.29e-20 Systemic lupus erythematosus; CRC cis rs28374715 0.528 rs28492932 chr15:41624397 G/C cg18705301 chr15:41695430 NDUFAF1 -1.09 -18.8 -0.72 4.4e-54 Ulcerative colitis; CRC cis rs71403859 0.667 rs12920890 chr16:71787588 G/A cg08717414 chr16:71523259 ZNF19 -1.01 -9.16 -0.45 5.49e-18 Post bronchodilator FEV1; CRC cis rs765787 0.530 rs12442533 chr15:45529631 G/C cg24006582 chr15:45444508 DUOX1 0.57 8.36 0.42 1.77e-15 Uric acid levels; CRC cis rs2832191 0.729 rs2832201 chr21:30499841 A/G cg08807101 chr21:30365312 RNF160 -0.69 -10.89 -0.51 8.74e-24 Dental caries; CRC cis rs8180040 0.783 rs11710121 chr3:47351501 T/G cg27129171 chr3:47204927 SETD2 -0.53 -7.67 -0.39 1.94e-13 Colorectal cancer; CRC cis rs6604026 0.922 rs66525381 chr1:93296764 A/G cg17283838 chr1:93427260 FAM69A 0.45 5.69 0.3 2.82e-8 Multiple sclerosis; CRC cis rs3820928 0.874 rs1917123 chr2:227889783 T/G cg11843606 chr2:227700838 RHBDD1 -0.39 -5.81 -0.31 1.45e-8 Pulmonary function; CRC cis rs10849893 0.576 rs889970 chr12:121856217 G/A cg01154721 chr12:121881891 KDM2B -0.41 -5.88 -0.31 9.99e-9 Fasting blood glucose;Fasting blood glucose (BMI interaction); CRC cis rs7659604 0.502 rs13108419 chr4:122687238 A/G cg19748678 chr4:122722346 EXOSC9 -0.42 -5.8 -0.3 1.54e-8 Type 2 diabetes; CRC cis rs7843479 0.965 rs17616085 chr8:21857267 C/T cg17168535 chr8:21777572 XPO7 0.57 9.24 0.45 3.08e-18 Mean corpuscular volume; CRC cis rs7666738 0.830 rs3846444 chr4:99032888 T/C cg05340658 chr4:99064831 C4orf37 0.61 9.42 0.46 8.23e-19 Colonoscopy-negative controls vs population controls; CRC cis rs34172651 0.545 rs8056132 chr16:24716348 A/G cg06028605 chr16:24865363 SLC5A11 0.32 6.19 0.32 1.83e-9 Intelligence (multi-trait analysis); CRC cis rs1005277 0.579 rs2504140 chr10:38387579 T/G cg00409905 chr10:38381863 ZNF37A -0.68 -11.32 -0.53 2.64e-25 Extrinsic epigenetic age acceleration; CRC cis rs7119 0.745 rs11632602 chr15:77809764 C/G cg27398640 chr15:77910606 LINGO1 -0.44 -7.9 -0.4 4.17e-14 Type 2 diabetes; CRC cis rs7223966 1.000 rs2665826 chr17:61944924 A/G cg23090583 chr17:61904693 PSMC5;FTSJ3 0.51 6.45 0.34 3.89e-10 Hip circumference adjusted for BMI;Body mass index; CRC cis rs6681460 0.932 rs602513 chr1:67177270 G/A cg02459107 chr1:67143332 SGIP1 0.37 6.54 0.34 2.35e-10 Presence of antiphospholipid antibodies; CRC cis rs10504229 0.906 rs7003276 chr8:58173089 A/T cg05313129 chr8:58192883 C8orf71 -0.46 -7.07 -0.36 9.56e-12 Developmental language disorder (linguistic errors); CRC trans rs2303319 0.504 rs12470743 chr2:162611202 G/A cg10272801 chr16:14013773 ERCC4 -0.68 -6.07 -0.32 3.49e-9 Cognitive function; CRC cis rs9894429 0.646 rs7220310 chr17:79606056 C/A cg13777783 chr17:79615861 NA -0.3 -5.6 -0.3 4.47e-8 Eye color traits; CRC cis rs910316 0.692 rs7156586 chr14:75506230 A/T cg11812906 chr14:75593930 NEK9 0.49 6.86 0.35 3.45e-11 Height; CRC cis rs3126085 0.515 rs7534951 chr1:152362972 C/T cg09127314 chr1:152161683 NA -0.44 -5.85 -0.31 1.2e-8 Atopic dermatitis; CRC cis rs9487051 0.676 rs7773213 chr6:109601885 C/T cg21918786 chr6:109611834 NA -0.42 -7.23 -0.37 3.41e-12 Reticulocyte fraction of red cells; CRC trans rs12495832 0.778 rs16860195 chr3:147924457 A/G cg10221266 chr7:153579447 NA 0.56 6.12 0.32 2.6e-9 Chin dimples; CRC trans rs951252 0.504 rs11734405 chr4:146081096 C/T cg15921587 chr2:73144353 EMX1 0.44 6.1 0.32 2.99e-9 Hip circumference; CRC cis rs7811142 1.000 rs11761784 chr7:100039970 C/T cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.14 17.63 0.7 1.96e-49 Platelet count; CRC cis rs9818758 0.607 rs11706052 chr3:49064110 A/G cg00383909 chr3:49044727 WDR6 1.31 12.49 0.57 1.46e-29 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; CRC cis rs1005277 0.579 rs2474569 chr10:38383491 C/G cg25517755 chr10:38738941 LOC399744 -0.44 -6.42 -0.33 4.85e-10 Extrinsic epigenetic age acceleration; CRC cis rs853679 1.000 rs1936365 chr6:28268452 C/G cg15845792 chr6:28175446 NA -0.62 -6.59 -0.34 1.73e-10 Depression; CRC cis rs1552244 0.810 rs7612908 chr3:10089148 A/G cg02579736 chr3:10068473 FANCD2;CIDECP 1.02 13.77 0.6 2.25e-34 Alzheimer's disease; CRC cis rs79349575 0.777 rs28517720 chr17:46976756 C/G cg00947319 chr17:47005597 UBE2Z -0.34 -5.94 -0.31 7.27e-9 Type 2 diabetes; CRC cis rs1552244 1.000 rs7637888 chr3:10080722 T/C cg13047869 chr3:10149882 C3orf24 0.57 7.76 0.39 1.1e-13 Alzheimer's disease; CRC trans rs10982213 0.830 rs2274163 chr9:117188714 C/T cg11164639 chr15:91192950 NA 0.38 6.39 0.33 5.54e-10 Interleukin-6 levels; CRC cis rs889398 0.715 rs13330951 chr16:69563842 C/T cg00738113 chr16:70207722 CLEC18C -0.32 -5.71 -0.3 2.51e-8 Body mass index; CRC cis rs9372498 0.536 rs9489460 chr6:118925754 C/T cg24463073 chr6:118973353 C6orf204 0.49 6.37 0.33 6.29e-10 Diastolic blood pressure; CRC cis rs4819052 0.851 rs2838842 chr21:46669217 C/T cg19498844 chr21:46707878 POFUT2;LOC642852 0.73 10.85 0.51 1.18e-23 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs7811142 1.000 rs11761725 chr7:100039815 C/T cg21679810 chr7:100027352 MEPCE;ZCWPW1 1.0 13.17 0.59 4.11e-32 Platelet count; CRC cis rs7909074 0.509 rs2026427 chr10:45389704 T/C cg05187965 chr10:45406764 TMEM72 -0.34 -7.01 -0.36 1.32e-11 Mean corpuscular volume; CRC cis rs7605827 0.930 rs10201925 chr2:15528742 G/A cg19274914 chr2:15703543 NA 0.39 5.89 0.31 9.73e-9 Educational attainment (years of education); CRC cis rs734999 0.505 rs4278312 chr1:2539555 A/G cg20673091 chr1:2541236 MMEL1 0.36 5.8 0.3 1.52e-8 Ulcerative colitis; CRC cis rs6502050 0.799 rs6502078 chr17:80124364 G/A cg19223190 chr17:80058835 NA 0.39 6.23 0.32 1.43e-9 Life satisfaction; CRC cis rs9322193 0.847 rs880246 chr6:150167108 G/A cg04369109 chr6:150039330 LATS1 -0.41 -5.61 -0.3 4.19e-8 Lung cancer; CRC cis rs4925386 1.000 rs1889201 chr20:60923075 C/T cg15193198 chr20:60906057 LAMA5 0.42 6.88 0.35 3.11e-11 Colorectal cancer;Colorectal cancer (SNP x SNP interaction); CRC cis rs2976388 0.609 rs2572908 chr8:143802636 A/G cg04969067 chr8:143858791 LYNX1 0.44 7.49 0.38 6.29e-13 Urinary tract infection frequency; CRC trans rs12599106 0.660 rs12919333 chr16:34991336 C/T cg20062050 chr1:227730881 NA 0.37 6.09 0.32 3.09e-9 Menopause (age at onset); CRC cis rs11098499 0.865 rs28753180 chr4:120405367 A/T cg09307838 chr4:120376055 NA 0.7 10.94 0.52 5.84e-24 Corneal astigmatism; CRC cis rs9611565 0.559 rs1006407 chr22:41972032 T/C cg06634786 chr22:41940651 POLR3H -0.62 -6.32 -0.33 8.57e-10 Vitiligo; CRC cis rs9611565 0.659 rs9607815 chr22:41950671 A/T cg06634786 chr22:41940651 POLR3H -0.66 -7.8 -0.4 8.05e-14 Vitiligo; CRC cis rs6938 0.534 rs1130741 chr15:75189930 A/G cg09165964 chr15:75287851 SCAMP5 0.57 9.15 0.45 5.96e-18 Breast cancer; CRC cis rs2692947 0.644 rs1168976 chr2:96813480 G/A cg23100626 chr2:96804247 ASTL 0.3 7.98 0.4 2.47e-14 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; CRC cis rs6743226 0.870 rs67652230 chr2:242235446 A/T cg10021735 chr2:242295487 FARP2 0.48 6.96 0.36 1.9e-11 Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI in non-smokers; CRC trans rs2303319 0.504 rs12467625 chr2:162603387 C/A cg23919916 chr10:103825097 HPS6 -0.69 -6.01 -0.31 4.8e-9 Cognitive function; CRC cis rs4563143 0.663 rs10417671 chr19:29235335 T/C cg14983838 chr19:29218262 NA 0.53 8.02 0.4 1.91e-14 Methadone dose in opioid dependence; CRC cis rs10504229 0.683 rs7459925 chr8:58111771 G/A cg21724239 chr8:58056113 NA 0.5 6.89 0.35 2.89e-11 Developmental language disorder (linguistic errors); CRC cis rs2243480 1.000 rs160642 chr7:65558373 C/T cg25985355 chr7:65971099 NA -0.47 -5.65 -0.3 3.54e-8 Diabetic kidney disease; CRC cis rs12477438 0.798 rs6712338 chr2:99585457 A/G cg26064155 chr2:99771622 LIPT1;TSGA10 -0.79 -11.26 -0.53 4.44e-25 Chronic sinus infection; CRC cis rs9807989 0.507 rs6755905 chr2:103048207 C/A cg03938978 chr2:103052716 IL18RAP 0.59 10.09 0.49 4.8e-21 Asthma; CRC cis rs7772486 0.846 rs2144478 chr6:146381445 A/G cg23711669 chr6:146136114 FBXO30 0.63 10.78 0.51 2.11e-23 Lobe attachment (rater-scored or self-reported); CRC trans rs208520 0.690 rs207082 chr6:66773796 G/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.04 -14.54 -0.63 2.39e-37 Exhaled nitric oxide output; CRC cis rs35000415 0.938 rs34381587 chr7:128666825 A/G cg19972273 chr7:128594194 NA 0.68 6.32 0.33 8.52e-10 Systemic lupus erythematosus; CRC cis rs10504229 1.000 rs66672857 chr8:58179817 G/C cg02290350 chr8:58132656 NA -0.42 -5.96 -0.31 6.62e-9 Developmental language disorder (linguistic errors); CRC trans rs2693676 0.920 rs1257483 chr14:99608934 A/C cg11190754 chr5:64858552 CENPK;PPWD1 -0.52 -6.51 -0.34 2.84e-10 Corneal curvature; CRC cis rs7843479 1.000 rs11775444 chr8:21813018 A/G cg17168535 chr8:21777572 XPO7 0.55 8.88 0.44 4.57e-17 Mean corpuscular volume; CRC cis rs4665809 0.567 rs6711402 chr2:26430983 A/G cg04944784 chr2:26401820 FAM59B -0.9 -11.02 -0.52 3.11e-24 Gut microbiome composition (summer); CRC cis rs9303401 0.659 rs62083368 chr17:56878062 G/A cg10487724 chr17:56770010 TEX14;RAD51C 0.77 9.54 0.47 3.4e-19 Cognitive test performance; CRC cis rs875971 0.522 rs2949690 chr7:65483242 C/T cg18912574 chr7:65842487 NCRNA00174 -0.34 -5.62 -0.3 4.08e-8 Aortic root size; CRC cis rs4925386 0.840 rs6143036 chr20:60921721 C/A cg24112000 chr20:60950667 NA -0.55 -8.57 -0.43 4.07e-16 Colorectal cancer;Colorectal cancer (SNP x SNP interaction); CRC cis rs400736 0.930 rs225100 chr1:8066914 C/T cg25007680 chr1:8021821 PARK7 -0.52 -7.27 -0.37 2.63e-12 Response to antidepressants and depression; CRC cis rs1519814 0.956 rs4871040 chr8:121131611 A/G cg22335954 chr8:121166405 COL14A1 -0.56 -6.3 -0.33 9.33e-10 Breast cancer; CRC cis rs10504229 0.906 rs7842482 chr8:58167720 A/T cg22535103 chr8:58192502 C8orf71 -0.69 -11.01 -0.52 3.32e-24 Developmental language disorder (linguistic errors); CRC cis rs6426558 0.537 rs4653813 chr1:227461510 G/C cg10327440 chr1:227177885 CDC42BPA 0.43 6.39 0.33 5.8e-10 Neutrophil percentage of white cells; CRC cis rs11098499 0.779 rs7356491 chr4:120381974 C/T cg24375607 chr4:120327624 NA 0.5 7.73 0.39 1.3e-13 Corneal astigmatism; CRC cis rs1448094 0.512 rs7299285 chr12:86244959 A/T cg18827107 chr12:86230957 RASSF9 -0.46 -7.53 -0.38 4.82e-13 Major depressive disorder; CRC cis rs9787249 0.957 rs11809515 chr1:40205326 C/A cg24920358 chr1:40204285 PPIE 0.56 8.31 0.42 2.47e-15 Blood protein levels; CRC cis rs4742903 0.935 rs10820602 chr9:106861282 C/T cg21169611 chr9:106856078 SMC2 0.42 5.83 0.31 1.31e-8 High-grade serous ovarian cancer;Breast cancer; CRC cis rs9329289 0.603 rs2458705 chr10:2541377 A/G cg05625103 chr10:2543513 NA 0.4 6.31 0.33 9.24e-10 Age-related hearing impairment; CRC cis rs9660992 0.573 rs1172159 chr1:205207512 T/C cg21643547 chr1:205240462 TMCC2 -0.37 -6.06 -0.32 3.67e-9 Mean corpuscular volume;Mean platelet volume; CRC cis rs1790761 0.967 rs1638565 chr11:67223921 A/C cg17375396 chr11:67202808 RPS6KB2 0.33 5.65 0.3 3.4e-8 Mean corpuscular volume; CRC cis rs1055129 0.537 rs1135640 chr17:73949540 C/G cg14829360 chr17:73884958 NA 0.34 5.82 0.31 1.37e-8 White matter hyperintensity burden; CRC cis rs13108904 0.934 rs13115173 chr4:1316824 T/C cg19318889 chr4:1322082 MAEA 0.41 5.93 0.31 7.58e-9 Obesity-related traits; CRC cis rs7772486 0.790 rs6570724 chr6:146151283 T/C cg13319975 chr6:146136371 FBXO30 -0.42 -6.33 -0.33 8.26e-10 Lobe attachment (rater-scored or self-reported); CRC cis rs8103278 0.793 rs59093775 chr19:46374037 G/A cg20908204 chr19:46285434 DMPK -0.3 -5.62 -0.3 4.16e-8 Coronary artery disease; CRC cis rs2276314 1.000 rs1789513 chr18:33545630 A/G cg05985134 chr18:33552581 C18orf21 -0.51 -6.99 -0.36 1.5e-11 Endometriosis;Drug-induced torsades de pointes; CRC trans rs10982213 0.830 rs2274163 chr9:117188714 C/T cg22345911 chr17:80231263 CSNK1D 0.34 6.71 0.35 8.76e-11 Interleukin-6 levels; CRC cis rs6500602 0.964 rs2304633 chr16:4496973 T/A cg08645402 chr16:4508243 NA 0.57 9.39 0.46 1.03e-18 Schizophrenia; CRC cis rs1552244 0.688 rs7645137 chr3:10020549 A/AT cg02579736 chr3:10068473 FANCD2;CIDECP 0.95 12.2 0.56 1.77e-28 Alzheimer's disease; CRC cis rs9858542 1.000 rs13085791 chr3:49721798 C/A cg00383909 chr3:49044727 WDR6 0.47 5.89 0.31 9.55e-9 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs17666538 0.585 rs1703927 chr8:613620 A/G cg00776166 chr8:613548 NA -0.59 -5.87 -0.31 1.05e-8 IgG glycosylation; CRC cis rs10489525 0.560 rs10858062 chr1:115602563 A/G cg12756093 chr1:115239321 AMPD1 -0.45 -5.66 -0.3 3.28e-8 Autism; CRC cis rs9549367 0.713 rs9549352 chr13:113833221 A/G cg18105134 chr13:113819100 PROZ -0.88 -12.74 -0.57 1.69e-30 Platelet distribution width; CRC trans rs4263408 0.934 rs9683743 chr4:39703194 A/C cg04919811 chr17:78870302 RPTOR -0.46 -7.2 -0.37 4.24e-12 Plasma amyloid beta peptide concentrations (ABx-40); CRC cis rs1005277 0.522 rs7090858 chr10:38003670 A/C cg00409905 chr10:38381863 ZNF37A 0.64 10.52 0.5 1.73e-22 Extrinsic epigenetic age acceleration; CRC cis rs2841277 0.708 rs4465542 chr14:105407798 A/G cg14403583 chr14:105418241 AHNAK2 -0.32 -5.84 -0.31 1.23e-8 Rheumatoid arthritis; CRC cis rs539514 0.637 rs2025354 chr13:76275577 T/C cg04757411 chr13:76259545 LMO7 -0.36 -6.06 -0.32 3.71e-9 Type 1 diabetes; CRC cis rs9916302 0.904 rs634365 chr17:37436966 C/T cg00129232 chr17:37814104 STARD3 -0.5 -7.52 -0.38 5.1e-13 Glomerular filtration rate (creatinine); CRC cis rs10504229 1.000 rs116995796 chr8:58181960 G/A cg24829409 chr8:58192753 C8orf71 -0.68 -11.34 -0.53 2.13e-25 Developmental language disorder (linguistic errors); CRC cis rs10504229 1.000 rs60454728 chr8:58173781 G/A cg01721255 chr8:58191610 C8orf71 0.49 6.17 0.32 2e-9 Developmental language disorder (linguistic errors); CRC cis rs4713118 0.955 rs9393847 chr6:27687973 G/A cg15845792 chr6:28175446 NA 0.6 7.79 0.39 8.56e-14 Parkinson's disease; CRC cis rs4680 1.000 rs4633 chr22:19950235 C/T cg01335087 chr22:19950166 COMT 0.23 6.31 0.33 9.22e-10 Blood metabolite levels; CRC cis rs853679 0.546 rs200996 chr6:27811828 G/A cg03623178 chr6:28175578 NA 0.78 6.94 0.36 2.07e-11 Depression; CRC cis rs9467773 0.550 rs9379874 chr6:26440429 A/T cg09904177 chr6:26538194 HMGN4 -0.44 -6.18 -0.32 1.89e-9 Intelligence (multi-trait analysis); CRC cis rs2386661 0.826 rs10905519 chr10:5672483 C/A cg26603656 chr10:5671107 NA 0.54 8.91 0.44 3.52e-17 Breast cancer; CRC cis rs870825 0.655 rs7675046 chr4:185652201 G/A cg04058563 chr4:185651563 MLF1IP -0.69 -8.69 -0.43 1.68e-16 Blood protein levels; CRC cis rs992157 0.732 rs10932771 chr2:219170236 A/T cg04880052 chr2:219191631 PNKD 0.41 6.73 0.35 7.38e-11 Colorectal cancer; CRC trans rs1413885 1.000 rs6588134 chr1:65816050 G/T cg26534493 chr8:28060551 NA -0.38 -6.21 -0.32 1.58e-9 Anticoagulant levels; CRC cis rs860295 0.702 rs475550 chr1:155652081 A/T cg02153340 chr1:155202674 NA -0.56 -7.11 -0.37 7.2e-12 Body mass index; CRC cis rs35110281 0.782 rs2246602 chr21:45064296 C/A cg04455712 chr21:45112962 RRP1B 0.42 8.25 0.41 3.95e-15 Mean corpuscular volume; CRC cis rs425277 0.606 rs2257182 chr1:2082566 C/T cg12639453 chr1:2035780 PRKCZ -0.32 -6.36 -0.33 6.75e-10 Height; CRC cis rs7412746 0.658 rs6660845 chr1:150841066 G/A cg18016565 chr1:150552671 MCL1 0.44 6.04 0.32 4.07e-9 Melanoma; CRC cis rs7647973 1.000 rs6783003 chr3:49524778 G/C cg20833759 chr3:49053208 WDR6;DALRD3 -0.62 -9.13 -0.45 7.11e-18 Menarche (age at onset); CRC cis rs875971 1.000 rs1183245 chr7:65541185 C/T cg12463550 chr7:65579703 CRCP -0.49 -6.98 -0.36 1.6e-11 Aortic root size; CRC cis rs2180341 1.000 rs2180341 chr6:127600630 C/T cg24812749 chr6:127587940 RNF146 0.94 13.52 0.6 2.07e-33 Breast cancer; CRC cis rs6540556 0.859 rs11119340 chr1:209940560 A/T cg05527609 chr1:210001259 C1orf107 0.62 6.91 0.36 2.58e-11 Red blood cell count; CRC cis rs12580194 0.593 rs12579346 chr12:55786856 A/G cg19537932 chr12:55886519 OR6C68 -0.72 -9.08 -0.45 9.94e-18 Cancer; CRC cis rs11758351 1.000 rs79868973 chr6:26189312 C/G cg01420254 chr6:26195488 NA 0.79 8.66 0.43 2.1e-16 Gout;Renal underexcretion gout; CRC cis rs17092148 0.887 rs6059915 chr20:33147737 C/G cg08999081 chr20:33150536 PIGU 0.51 6.51 0.34 2.85e-10 Neuroticism; CRC cis rs1044826 0.667 rs2083336 chr3:139201272 T/G cg00490450 chr3:139108681 COPB2 0.44 6.59 0.34 1.75e-10 Obesity-related traits; CRC cis rs4731207 0.698 rs6977407 chr7:124499002 A/C cg23710748 chr7:124431027 NA -0.38 -6.08 -0.32 3.31e-9 Cutaneous malignant melanoma; CRC cis rs12477438 0.520 rs4347885 chr2:99804007 G/A cg26064155 chr2:99771622 LIPT1;TSGA10 0.77 12.9 0.58 4.48e-31 Chronic sinus infection; CRC cis rs17253792 0.822 rs77182097 chr14:56136695 G/A cg01858014 chr14:56050164 KTN1 -0.85 -7.21 -0.37 3.89e-12 Putamen volume; CRC trans rs4576506 0.536 rs71512720 chr9:31499511 G/A cg26940518 chr16:1593766 IFT140;TMEM204 -0.66 -6.02 -0.31 4.6e-9 Psychosis and Alzheimer's disease; CRC trans rs1005277 0.522 rs289647 chr10:37968278 A/G cg17830980 chr10:43048298 ZNF37B -0.46 -7.05 -0.36 1.04e-11 Extrinsic epigenetic age acceleration; CRC cis rs6456156 0.565 rs12525345 chr6:167478875 T/C cg07741184 chr6:167504864 NA 0.39 6.86 0.35 3.43e-11 Primary biliary cholangitis; CRC cis rs41271951 0.512 rs16832976 chr1:151038135 T/C cg11822372 chr1:151115635 SEMA6C -0.71 -5.74 -0.3 2.12e-8 Blood protein levels; CRC cis rs8180040 0.593 rs4018905 chr3:47138170 A/G cg02527881 chr3:46936655 PTH1R -0.34 -5.95 -0.31 6.84e-9 Colorectal cancer; CRC cis rs10504229 0.906 rs114810777 chr8:58185298 A/G cg01721255 chr8:58191610 C8orf71 0.48 6.0 0.31 5.08e-9 Developmental language disorder (linguistic errors); CRC cis rs7833790 0.632 rs6473308 chr8:82707708 G/A cg17211192 chr8:82754475 SNX16 -0.47 -6.56 -0.34 2.12e-10 Diastolic blood pressure; CRC trans rs2303319 0.504 rs62189051 chr2:162622318 G/A cg23919916 chr10:103825097 HPS6 -0.69 -5.99 -0.31 5.54e-9 Cognitive function; CRC cis rs597539 0.652 rs686877 chr11:68637169 G/A cg21963583 chr11:68658836 MRPL21 0.59 10.65 0.51 6e-23 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg09610735 chr10:22609918 BMI1 0.49 6.49 0.34 3.21e-10 Thyroid stimulating hormone; CRC cis rs7927771 0.839 rs11039308 chr11:47622412 G/A cg18512352 chr11:47633146 NA -0.37 -7.33 -0.37 1.75e-12 Subjective well-being; CRC cis rs9329289 0.550 rs11251294 chr10:2562328 C/T cg15501526 chr10:2543763 NA -0.54 -9.63 -0.47 1.66e-19 Age-related hearing impairment; CRC cis rs6032067 0.929 rs17424474 chr20:43804797 C/A cg10761708 chr20:43804764 PI3 0.5 5.8 0.3 1.54e-8 Blood protein levels; CRC cis rs6921919 0.638 rs6456815 chr6:28306137 C/A cg21251018 chr6:28226885 NKAPL 0.49 7.8 0.4 8.17e-14 Autism spectrum disorder or schizophrenia; CRC cis rs6460942 0.591 rs4721082 chr7:12341804 A/G cg06484146 chr7:12443880 VWDE -0.61 -6.56 -0.34 2.05e-10 Coronary artery disease; CRC cis rs7647973 0.696 rs7100 chr3:49053219 A/G cg07636037 chr3:49044803 WDR6 0.85 10.35 0.5 6.22e-22 Menarche (age at onset); CRC cis rs4819052 0.851 rs9979545 chr21:46679805 G/A cg11663144 chr21:46675770 NA -0.85 -14.81 -0.63 2.22e-38 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs6942756 0.744 rs2718088 chr7:128927020 C/A cg02491457 chr7:128862824 NA 0.67 9.31 0.46 1.94e-18 White matter hyperintensity burden; CRC cis rs1862618 0.802 rs33327 chr5:56142693 T/G cg03609598 chr5:56110824 MAP3K1 -0.82 -9.92 -0.48 1.82e-20 Initial pursuit acceleration; CRC cis rs4780401 0.729 rs8045300 chr16:11769266 C/G cg01061890 chr16:11836724 TXNDC11 -0.42 -5.8 -0.3 1.52e-8 Rheumatoid arthritis; CRC cis rs11098499 0.954 rs2389802 chr4:120325732 C/A cg24375607 chr4:120327624 NA 0.51 7.98 0.4 2.49e-14 Corneal astigmatism; CRC cis rs7927771 0.864 rs7107726 chr11:47429245 T/A cg18512352 chr11:47633146 NA -0.42 -8.15 -0.41 7.88e-15 Subjective well-being; CRC cis rs9894429 0.621 rs7502337 chr17:79588470 T/C cg21028142 chr17:79581711 NPLOC4 0.34 6.99 0.36 1.58e-11 Eye color traits; CRC cis rs11122272 0.735 rs722302 chr1:231480152 A/C cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.55 -8.2 -0.41 5.35e-15 Hemoglobin concentration; CRC cis rs9326248 0.861 rs7120309 chr11:117042816 T/A cg26566898 chr11:117069891 TAGLN 0.39 6.99 0.36 1.51e-11 Blood protein levels; CRC cis rs1152591 0.562 rs1272715 chr14:64651989 A/T cg21174375 chr14:64681225 SYNE2 0.4 6.47 0.34 3.45e-10 Atrial fibrillation; CRC trans rs11098499 0.909 rs35165976 chr4:120325630 G/A cg25214090 chr10:38739885 LOC399744 0.65 10.34 0.5 6.98e-22 Corneal astigmatism; CRC cis rs9858542 1.000 rs9822268 chr3:49719729 G/A cg03060546 chr3:49711283 APEH -0.5 -6.79 -0.35 5.18e-11 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs3858526 0.523 rs10838749 chr11:5884246 A/G cg26762873 chr11:5879799 OR52E8 -0.49 -7.42 -0.38 1.01e-12 DNA methylation (variation); CRC cis rs6582630 0.599 rs1589392 chr12:38418535 G/C cg26384229 chr12:38710491 ALG10B -0.53 -7.57 -0.38 3.88e-13 Drug-induced liver injury (flucloxacillin); CRC cis rs4731207 0.569 rs1600746 chr7:124585095 T/G cg23710748 chr7:124431027 NA -0.38 -6.08 -0.32 3.35e-9 Cutaneous malignant melanoma; CRC cis rs4713118 0.824 rs9468229 chr6:27750086 G/A cg03623178 chr6:28175578 NA 0.7 9.33 0.46 1.61e-18 Parkinson's disease; CRC cis rs896854 0.608 rs6991067 chr8:95875676 A/G cg16049864 chr8:95962084 TP53INP1 -0.59 -10.14 -0.49 3.28e-21 Type 2 diabetes; CRC cis rs780096 0.526 rs4803 chr2:27667297 A/G cg22903471 chr2:27725779 GCKR -0.37 -6.05 -0.32 4.04e-9 Total body bone mineral density; CRC cis rs3857067 1.000 rs3846291 chr4:95026735 A/G cg11021082 chr4:95130006 SMARCAD1 -0.42 -6.41 -0.33 4.99e-10 QT interval; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg00366722 chr15:37393576 MEIS2 0.43 6.38 0.33 5.95e-10 Intelligence (multi-trait analysis); CRC cis rs758324 0.812 rs494349 chr5:131260452 C/A cg25547332 chr5:131281432 NA -0.36 -5.81 -0.31 1.47e-8 Alzheimer's disease in APOE e4- carriers; CRC cis rs6963495 0.818 rs6943132 chr7:105166776 C/T cg13798780 chr7:105162888 PUS7 0.68 7.51 0.38 5.77e-13 Bipolar disorder (body mass index interaction); CRC cis rs9611565 0.573 rs9306355 chr22:42111896 A/T cg03806693 chr22:41940476 POLR3H 0.67 9.45 0.46 6.78e-19 Vitiligo; CRC cis rs13191362 1.000 rs67840803 chr6:163049048 C/T cg06582575 chr6:163149167 PACRG;PARK2 0.91 11.36 0.53 1.84e-25 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs6690583 0.697 rs10873684 chr1:85522196 T/C cg11262906 chr1:85462892 MCOLN2 -0.5 -6.96 -0.36 1.83e-11 Serum sulfate level; CRC cis rs11608355 0.508 rs11066394 chr12:109799212 C/A cg19025524 chr12:109796872 NA -0.48 -7.15 -0.37 5.77e-12 Neuroticism; CRC cis rs1355223 0.583 rs2116085 chr11:34884001 C/A cg11058730 chr11:34937778 PDHX;APIP 0.74 12.06 0.55 5.41e-28 Systemic lupus erythematosus and Systemic sclerosis; CRC cis rs2180341 0.814 rs9401958 chr6:127736357 T/G cg24812749 chr6:127587940 RNF146 0.67 9.13 0.45 7.3e-18 Breast cancer; CRC cis rs11148252 0.500 rs342768 chr13:53208882 C/T cg20354231 chr13:53171401 NA -0.5 -8.08 -0.41 1.22e-14 Lewy body disease; CRC cis rs1448094 0.817 rs10863112 chr12:86330844 C/T cg02569458 chr12:86230093 RASSF9 0.46 7.68 0.39 1.89e-13 Major depressive disorder; CRC cis rs780096 0.546 rs1104 chr2:27599875 T/G cg21248554 chr2:27665150 KRTCAP3 -0.31 -7.14 -0.37 5.9e-12 Total body bone mineral density; CRC cis rs2836974 0.897 rs2026267 chr21:40711477 C/A cg11890956 chr21:40555474 PSMG1 0.98 14.83 0.63 1.86e-38 Cognitive function; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg04335102 chr3:123680028 CCDC14 0.44 6.01 0.31 5.06e-9 Response to antipsychotic treatment; CRC cis rs6684514 0.922 rs12037778 chr1:156284864 A/G cg16558208 chr1:156270281 VHLL 0.57 8.89 0.44 4.08e-17 Mean corpuscular hemoglobin concentration;Glycated hemoglobin levels; CRC cis rs6963495 1.000 rs6963495 chr7:105166853 T/C cg02135003 chr7:105160482 PUS7 -0.92 -10.26 -0.49 1.32e-21 Bipolar disorder (body mass index interaction); CRC cis rs9296092 0.560 rs9469511 chr6:33530930 T/G cg13560919 chr6:33536144 NA -0.42 -5.69 -0.3 2.78e-8 Age at smoking initiation in chronic obstructive pulmonary disease; CRC trans rs1005277 0.579 rs176886 chr10:38403974 C/T cg17830980 chr10:43048298 ZNF37B -0.6 -9.93 -0.48 1.65e-20 Extrinsic epigenetic age acceleration; CRC cis rs2070488 0.775 rs961179 chr3:38509618 G/A cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.79 13.72 0.6 3.52e-34 Electrocardiographic conduction measures; CRC trans rs2303319 0.504 rs1006428 chr2:162592559 A/C cg22902534 chr3:183892754 AP2M1 -0.7 -6.1 -0.32 2.96e-9 Cognitive function; CRC cis rs1023500 0.573 rs6002592 chr22:42476754 A/C cg11915388 chr22:42470451 FAM109B 0.42 6.34 0.33 7.46e-10 Schizophrenia; CRC cis rs10986311 0.862 rs11791290 chr9:127096347 C/T cg14243010 chr9:127117328 LOC100129034;PSMB7 0.41 6.18 0.32 1.85e-9 Vitiligo; CRC cis rs17376456 0.569 rs17083377 chr5:93164870 C/G cg25358565 chr5:93447407 FAM172A 0.65 8.17 0.41 6.53e-15 Diabetic retinopathy; CRC cis rs7959452 0.868 rs10878967 chr12:69740869 T/C cg22834771 chr12:69754056 YEATS4 -0.47 -6.91 -0.36 2.44e-11 Blood protein levels; CRC cis rs1005277 0.579 rs2103938 chr10:38493998 T/G cg03665457 chr10:38645376 HSD17B7P2 -0.42 -5.94 -0.31 7.25e-9 Extrinsic epigenetic age acceleration; CRC cis rs4073416 0.542 rs10143206 chr14:66120675 A/G cg03016385 chr14:66212404 NA 0.44 6.07 0.32 3.54e-9 N-glycan levels; CRC cis rs9896933 0.667 rs2253131 chr17:80696547 T/A cg20578329 chr17:80767326 TBCD -0.81 -10.11 -0.49 4.36e-21 Bone mineral accretion in asthma (oral corticosteroid dose interaction); CRC cis rs853679 0.825 rs8180562 chr6:28141460 G/A cg06470822 chr6:28175283 NA 0.78 6.19 0.32 1.76e-9 Depression; CRC cis rs924607 0.966 rs1621827 chr5:635074 A/G cg09021430 chr5:549028 NA -0.51 -8.45 -0.42 9.25e-16 Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia; CRC cis rs644148 0.770 rs2571113 chr19:44999814 A/G cg15540054 chr19:45004280 ZNF180 -0.59 -8.24 -0.41 4.15e-15 Personality dimensions; CRC trans rs10982213 0.830 rs2274163 chr9:117188714 C/T cg04761648 chr13:26829199 CDK8 -0.43 -6.64 -0.34 1.3100000000000001e-10 Interleukin-6 levels; CRC cis rs13108904 0.837 rs4591539 chr4:1279938 G/C cg02018176 chr4:1364513 KIAA1530 0.48 7.84 0.4 6.25e-14 Obesity-related traits; CRC cis rs801193 0.967 rs2707841 chr7:66157020 A/G cg00343986 chr7:65444356 GUSB 0.5 7.38 0.38 1.34e-12 Aortic root size; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg27249304 chr10:71906591 TYSND1 0.42 6.79 0.35 5.17e-11 Liver disease severity in Alagille syndrome; CRC cis rs17826219 0.714 rs11650821 chr17:28968150 T/C cg01831904 chr17:28903510 LRRC37B2 -0.61 -6.19 -0.32 1.81e-9 Body mass index; CRC trans rs6600671 0.934 rs11249429 chr1:121291080 C/T cg09829573 chr1:144692074 NBPF9 0.41 6.22 0.32 1.53e-9 Hip geometry; CRC cis rs11792861 0.926 rs77567374 chr9:111835034 T/C cg05043794 chr9:111880884 C9orf5 -0.37 -6.62 -0.34 1.43e-10 Menarche (age at onset); CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg27106230 chr13:99229068 STK24 -0.39 -6.11 -0.32 2.88e-9 Myopia (pathological); CRC cis rs7586673 0.930 rs2884364 chr2:161977647 G/A cg22496339 chr2:162101262 NA 0.6 8.64 0.43 2.47e-16 Intelligence (multi-trait analysis); CRC cis rs6570726 0.693 rs450921 chr6:145864260 C/T cg23711669 chr6:146136114 FBXO30 0.76 13.16 0.59 4.67e-32 Lobe attachment (rater-scored or self-reported); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg14704270 chr22:50639024 SELO 0.4 6.61 0.34 1.52e-10 Liver disease severity in Alagille syndrome; CRC cis rs17253792 0.822 rs75995456 chr14:56073194 A/G cg01858014 chr14:56050164 KTN1 -0.87 -7.23 -0.37 3.34e-12 Putamen volume; CRC cis rs9868809 0.505 rs11708786 chr3:48752654 C/T cg00383909 chr3:49044727 WDR6 0.76 8.1 0.41 1.09e-14 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; CRC cis rs9811920 0.809 rs6806323 chr3:99722564 C/G cg07805332 chr3:99536008 MIR548G;C3orf26 0.38 5.91 0.31 8.34e-9 Axial length; CRC cis rs2692947 0.832 rs62153679 chr2:96558400 C/T cg23100626 chr2:96804247 ASTL 0.27 7.11 0.36 7.24e-12 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; CRC cis rs9902453 1.000 rs7222308 chr17:28277041 T/C cg26525008 chr17:28256777 EFCAB5;SSH2 0.59 8.98 0.44 2.16e-17 Coffee consumption (cups per day); CRC cis rs1005277 0.505 rs7069702 chr10:38247359 G/T cg25427524 chr10:38739819 LOC399744 0.76 13.35 0.59 8.45e-33 Extrinsic epigenetic age acceleration; CRC cis rs7572644 0.679 rs9679543 chr2:28050951 C/T cg27432699 chr2:27873401 GPN1 0.47 6.24 0.33 1.33e-9 Response to carboplatin and paclitaxel in ovarian cancer (Caspase 3/7 EC50); CRC cis rs7772486 0.714 rs1883365 chr6:146076749 C/T cg13319975 chr6:146136371 FBXO30 0.44 6.52 0.34 2.71e-10 Lobe attachment (rater-scored or self-reported); CRC cis rs7552404 0.731 rs17650138 chr1:76398887 C/T cg10523679 chr1:76189770 ACADM -0.7 -8.4 -0.42 1.39e-15 Blood metabolite levels;Acylcarnitine levels; CRC cis rs12922317 0.856 rs1641835 chr16:12136584 T/C cg02368508 chr16:12060182 TNFRSF17 -0.39 -5.77 -0.3 1.87e-8 Schizophrenia; CRC cis rs798554 0.757 rs1182178 chr7:2873763 G/A cg19346786 chr7:2764209 NA -0.41 -6.99 -0.36 1.56e-11 Height; CRC cis rs2456568 0.802 rs7101791 chr11:93638998 A/G cg26875233 chr11:93583750 C11orf90 -0.31 -6.03 -0.32 4.38e-9 Response to serotonin reuptake inhibitors in major depressive disorder; CRC cis rs611744 0.647 rs1584373 chr8:109263399 C/A cg18478394 chr8:109455254 TTC35 0.38 5.82 0.31 1.41e-8 Dupuytren's disease; CRC cis rs13315871 0.858 rs78946071 chr3:58318523 G/T cg20936604 chr3:58311152 NA -0.75 -7.03 -0.36 1.18e-11 Cholesterol, total; CRC cis rs889398 0.835 rs62050037 chr16:69784670 T/C cg00738113 chr16:70207722 CLEC18C 0.36 6.0 0.31 5.24e-9 Body mass index; CRC cis rs1008375 1.000 rs10012335 chr4:17628630 C/G cg02297831 chr4:17616191 MED28 0.44 5.87 0.31 1.05e-8 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs7224737 1.000 rs739637 chr17:40280944 G/C cg00647820 chr17:40259828 DHX58 -0.46 -6.59 -0.34 1.78e-10 Fibrinogen levels; CRC cis rs6534441 0.857 rs28733585 chr4:125455249 C/T cg21609808 chr4:125404261 NA 0.39 5.83 0.31 1.3e-8 Major depressive disorder; CRC cis rs7615952 0.599 rs12485717 chr3:125707075 C/T cg06494592 chr3:125709126 NA 0.52 6.2 0.32 1.65e-9 Blood pressure (smoking interaction); CRC cis rs1448094 0.512 rs2405632 chr12:86252456 A/G cg02569458 chr12:86230093 RASSF9 0.43 7.45 0.38 8.03e-13 Major depressive disorder; CRC cis rs7772486 0.875 rs2328712 chr6:146344563 T/C cg23711669 chr6:146136114 FBXO30 0.61 10.36 0.5 5.88e-22 Lobe attachment (rater-scored or self-reported); CRC cis rs7412746 0.611 rs12085336 chr1:150775780 A/T cg15448220 chr1:150897856 SETDB1 0.51 7.3 0.37 2.22e-12 Melanoma; CRC cis rs10791097 0.694 rs11222370 chr11:130744767 T/G cg12179176 chr11:130786555 SNX19 0.75 12.66 0.57 3.46e-30 Autism spectrum disorder or schizophrenia;Schizophrenia; CRC cis rs6831352 0.959 rs6532795 chr4:100042221 C/T cg13256891 chr4:100009986 ADH5 -0.58 -8.22 -0.41 4.66e-15 Alcohol dependence; CRC trans rs9858542 0.953 rs6809216 chr3:49412559 G/A cg21582582 chr3:182698605 DCUN1D1 -0.52 -6.61 -0.34 1.52e-10 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs10883723 0.773 rs7917402 chr10:104246690 C/T cg04362960 chr10:104952993 NT5C2 -0.43 -6.02 -0.32 4.58e-9 Allergic disease (asthma, hay fever or eczema); CRC cis rs9292777 0.863 rs10473187 chr5:40385134 C/T cg09067459 chr5:40385259 NA 0.55 9.73 0.47 7.83e-20 Crohn's disease;Multiple sclerosis; CRC trans rs637571 0.522 rs542332 chr11:65744421 C/T cg17712092 chr4:129076599 LARP1B 0.66 10.86 0.51 1.13e-23 Eosinophil percentage of white cells; CRC cis rs826838 0.806 rs826873 chr12:39121305 G/A cg13010199 chr12:38710504 ALG10B -0.4 -5.73 -0.3 2.31e-8 Heart rate; CRC cis rs867529 0.695 rs335115 chr2:89027647 C/T cg26627705 chr2:89060884 NA 0.57 8.01 0.4 2.04e-14 Height; CRC cis rs3749237 0.595 rs4855859 chr3:49526300 C/T cg03060546 chr3:49711283 APEH 0.69 11.93 0.55 1.62e-27 Resting heart rate; CRC cis rs2895526 0.521 rs6602606 chr10:12713901 C/T cg00115178 chr10:12648176 CAMK1D -0.36 -5.92 -0.31 8.11e-9 Headache; CRC cis rs7762018 0.655 rs2184195 chr6:170148397 C/T cg19338460 chr6:170058176 WDR27 -0.69 -7.6 -0.39 3.03e-13 Thiazide-induced adverse metabolic effects in hypertensive patients; CRC cis rs2404602 1.000 rs12443137 chr15:76840832 G/T cg22467129 chr15:76604101 ETFA -0.39 -6.59 -0.34 1.72e-10 Blood metabolite levels; CRC cis rs7618915 0.571 rs12632381 chr3:52607685 G/A cg08222913 chr3:52553049 STAB1 -0.34 -6.29 -0.33 9.82e-10 Bipolar disorder; CRC cis rs96067 0.711 rs272833 chr1:36622870 C/G cg25304816 chr1:36627734 MAP7D1 0.5 7.43 0.38 9.65e-13 Corneal structure; CRC cis rs11711311 1.000 rs2566968 chr3:113474154 G/A cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.52 -7.18 -0.37 4.74e-12 IgG glycosylation; CRC cis rs2734839 0.929 rs7131627 chr11:113299829 G/A cg14159747 chr11:113255604 NA 0.47 8.32 0.42 2.34e-15 Information processing speed; CRC cis rs7044106 0.791 rs4836830 chr9:123483668 A/G cg09586646 chr9:123605570 PSMD5;LOC253039 0.68 10.02 0.48 8.55e-21 Hip circumference adjusted for BMI; CRC cis rs13256369 0.802 rs12680019 chr8:8561698 A/G cg06636001 chr8:8085503 FLJ10661 0.48 6.11 0.32 2.78e-9 Obesity-related traits; CRC cis rs2303759 0.551 rs7249040 chr19:49790602 C/T cg22590775 chr19:49891494 CCDC155 0.59 7.78 0.39 9.46e-14 Multiple sclerosis; CRC cis rs9925964 0.748 rs4889603 chr16:30982225 C/T cg03418659 chr16:31128414 MYST1 -0.42 -6.23 -0.32 1.47e-9 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs524281 1.000 rs527897 chr11:65900777 C/T cg14036092 chr11:66035641 RAB1B -0.46 -6.32 -0.33 8.27e-10 Electroencephalogram traits; CRC cis rs798554 0.757 rs1182187 chr7:2870454 T/G cg19717773 chr7:2847554 GNA12 -0.47 -6.79 -0.35 5.31e-11 Height; CRC cis rs1552244 1.000 rs28684871 chr3:10072635 C/A cg18598329 chr3:10140678 FANCD2;C3orf24 -0.87 -11.94 -0.55 1.51e-27 Alzheimer's disease; CRC cis rs7666738 0.791 rs1527516 chr4:98967937 A/C cg05340658 chr4:99064831 C4orf37 0.61 9.57 0.47 2.66e-19 Colonoscopy-negative controls vs population controls; CRC trans rs892961 0.931 rs2411110 chr17:75400143 A/C cg00502932 chr1:2160666 SKI -0.52 -6.11 -0.32 2.78e-9 Airflow obstruction; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg00171983 chr16:9185448 C16orf72 0.51 7.19 0.37 4.32e-12 Response to antipsychotic treatment; CRC trans rs12495832 0.778 rs76109782 chr3:147904411 T/C cg10221266 chr7:153579447 NA 0.55 6.06 0.32 3.81e-9 Chin dimples; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg10780647 chr20:3800838 C20orf29 0.37 5.99 0.31 5.57e-9 Liver disease severity in Alagille syndrome; CRC cis rs60871478 1.000 rs62432242 chr7:797715 G/A cg04727924 chr7:799746 HEATR2 -0.44 -6.42 -0.33 4.8e-10 Cerebrospinal P-tau181p levels; CRC cis rs7731657 0.575 rs12513465 chr5:130364503 A/G cg08523029 chr5:130500466 HINT1 -0.45 -5.94 -0.31 7.42e-9 Fasting plasma glucose; CRC cis rs7945718 0.934 rs10831907 chr11:12790875 C/T cg25843174 chr11:12811716 TEAD1 -0.5 -9.51 -0.46 4.11e-19 Educational attainment (years of education); CRC cis rs7904985 0.889 rs1078789 chr10:88110247 C/T cg07322936 chr10:88137208 NA -0.5 -7.21 -0.37 3.94e-12 Barrett's esophagus; CRC trans rs853679 0.882 rs9366717 chr6:28191057 C/T cg06606381 chr12:133084897 FBRSL1 -1.04 -8.72 -0.43 1.41e-16 Depression; CRC cis rs9486719 1.000 rs4077932 chr6:96905144 C/T cg18709589 chr6:96969512 KIAA0776 -0.51 -5.74 -0.3 2.15e-8 Migraine;Coronary artery disease; CRC trans rs2228479 0.850 rs11076624 chr16:89855749 T/C cg24644049 chr4:85504048 CDS1 0.83 7.0 0.36 1.47e-11 Skin colour saturation; CRC cis rs4478137 0.931 rs11100488 chr4:164237660 C/A cg06758707 chr4:164254230 NPY1R 0.39 5.98 0.31 5.87e-9 Subjective well-being (multi-trait analysis);Subjective well-being; CRC cis rs12681287 0.517 rs13249753 chr8:87513216 A/G cg27223183 chr8:87520930 FAM82B -0.52 -7.23 -0.37 3.5e-12 Caudate activity during reward; CRC cis rs763014 0.966 rs4984675 chr16:670117 T/C cg02475695 chr16:616220 NHLRC4 0.45 7.32 0.37 1.95e-12 Height; CRC cis rs9768139 0.708 rs10262596 chr7:158114495 G/A cg24154853 chr7:158122151 PTPRN2 0.59 9.88 0.48 2.43e-20 Calcium levels; CRC cis rs4243830 0.850 rs12744992 chr1:6601290 G/A cg15205204 chr1:6545172 PLEKHG5 0.38 5.66 0.3 3.22e-8 Body mass index; CRC cis rs7493 0.901 rs17879517 chr7:95030646 T/C cg19678392 chr7:94953810 PON1 -0.56 -6.95 -0.36 1.99e-11 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs4862750 0.872 rs9998173 chr4:187898778 T/A cg22105103 chr4:187893119 NA 0.64 11.62 0.54 2.13e-26 Lobe attachment (rater-scored or self-reported); CRC cis rs4073582 0.595 rs801734 chr11:65931216 T/C cg16950941 chr11:66035639 RAB1B 0.7 12.08 0.55 4.69e-28 Gout; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg01814186 chr16:69600788 NFAT5;MIR1538 0.49 6.34 0.33 7.51e-10 Thyroid stimulating hormone; CRC cis rs10861342 1.000 rs11112368 chr12:105494218 T/C cg23923672 chr12:105501055 KIAA1033 0.62 5.82 0.31 1.4e-8 IgG glycosylation; CRC cis rs28386778 0.863 rs11649912 chr17:61797515 T/A cg23090583 chr17:61904693 PSMC5;FTSJ3 1.02 19.35 0.73 2.98e-56 Prudent dietary pattern; CRC cis rs12044355 0.927 rs12043433 chr1:231843591 A/G cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX 0.44 5.95 0.31 6.93e-9 Alzheimer's disease; CRC cis rs3617 0.625 rs7652667 chr3:52866535 C/A cg18099408 chr3:52552593 STAB1 0.35 6.1 0.32 2.91e-9 Red blood cell count;Autism spectrum disorder or schizophrenia; CRC cis rs7249142 0.549 rs741706 chr19:19281672 C/T cg26504305 chr19:19281019 LOC729991-MEF2B;MEF2B -0.44 -8.86 -0.44 5.26e-17 IgG glycosylation; CRC cis rs10479542 0.784 rs7703730 chr5:178986632 C/A cg09060608 chr5:178986726 RUFY1 -0.47 -8.01 -0.4 2e-14 Lung cancer; CRC cis rs6502050 0.769 rs9898542 chr17:80119682 C/T cg22110888 chr17:80059540 CCDC57 0.4 6.38 0.33 5.96e-10 Life satisfaction; CRC cis rs875971 0.830 rs28714531 chr7:65968237 G/A cg12463550 chr7:65579703 CRCP 0.46 6.27 0.33 1.12e-9 Aortic root size; CRC cis rs12701220 0.541 rs12535516 chr7:1114440 C/G cg00990874 chr7:1149470 C7orf50 -0.47 -5.74 -0.3 2.14e-8 Bronchopulmonary dysplasia; CRC cis rs4654899 0.785 rs9426736 chr1:21505931 T/G cg02927042 chr1:21476669 EIF4G3 -0.39 -6.17 -0.32 2.01e-9 Superior frontal gyrus grey matter volume; CRC cis rs12477438 0.539 rs12999417 chr2:99865548 A/G cg14399236 chr2:99771627 LIPT1;TSGA10 -0.75 -12.81 -0.58 9.18e-31 Chronic sinus infection; CRC cis rs60843830 1.000 rs7605824 chr2:280819 A/G cg25945732 chr2:264204 ACP1;SH3YL1 -0.72 -11.8 -0.55 4.76e-27 Spherical equivalent (joint analysis main effects and education interaction); CRC cis rs798554 0.524 rs2283784 chr7:2855337 T/C cg19717773 chr7:2847554 GNA12 -0.46 -7.77 -0.39 1.04e-13 Height; CRC cis rs9311474 0.607 rs4234633 chr3:52557038 C/T cg15147215 chr3:52552868 STAB1 -0.66 -11.38 -0.53 1.56e-25 Electroencephalogram traits; CRC cis rs4665809 1.000 rs7588802 chr2:26277789 A/G cg25036284 chr2:26402008 FAM59B -0.47 -6.23 -0.32 1.45e-9 Gut microbiome composition (summer); CRC cis rs2011503 0.891 rs2965190 chr19:19451591 A/G cg11584989 chr19:19387371 SF4 -0.48 -6.04 -0.32 4.22e-9 Bipolar disorder; CRC trans rs2553218 0.690 rs8032415 chr15:54851945 A/G cg04139300 chr20:40247070 CHD6 0.44 6.02 0.31 4.55e-9 Immune response to smallpox vaccine (IL-6); CRC cis rs769267 0.930 rs1865034 chr19:19605763 C/T cg01262667 chr19:19385393 TM6SF2 0.36 5.87 0.31 1.06e-8 Tonsillectomy; CRC cis rs9457247 0.508 rs6918286 chr6:167505829 C/T cg07741184 chr6:167504864 NA 0.37 6.7 0.35 9.13e-11 Crohn's disease; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg26155979 chr10:105110866 PCGF6 0.4 7.23 0.37 3.37e-12 Liver disease severity in Alagille syndrome; CRC trans rs61931739 0.517 rs2636074 chr12:34064056 C/T cg26384229 chr12:38710491 ALG10B 0.51 7.01 0.36 1.36e-11 Morning vs. evening chronotype; CRC cis rs2857891 1.000 rs72845397 chr11:6950903 C/T cg14883916 chr11:6947541 ZNF215 0.63 6.87 0.35 3.29e-11 Response to cytadine analogues (cytosine arabinoside); CRC cis rs739401 0.572 rs7111857 chr11:3068106 A/G cg25174290 chr11:3078921 CARS -0.49 -7.49 -0.38 6.57e-13 Longevity; CRC cis rs2832191 0.791 rs2832199 chr21:30498501 G/A cg24692254 chr21:30365293 RNF160 -0.68 -11.42 -0.53 1.12e-25 Dental caries; CRC cis rs72781680 1.000 rs12616985 chr2:24165511 A/C cg08917208 chr2:24149416 ATAD2B 0.91 9.24 0.45 3.06e-18 Lymphocyte counts; CRC cis rs13191362 1.000 rs13214516 chr6:163121583 A/T cg21926612 chr6:163149169 PACRG;PARK2 0.97 12.63 0.57 4.27e-30 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs4728302 0.838 rs6954700 chr7:133588739 G/A cg03336402 chr7:133662267 EXOC4 -0.44 -6.37 -0.33 6.27e-10 Intelligence;Intelligence (multi-trait analysis); CRC cis rs972578 0.967 rs2267477 chr22:43334574 G/C cg01576275 chr22:43409880 NA -0.45 -7.24 -0.37 3.18e-12 Mean platelet volume; CRC cis rs995000 0.931 rs641540 chr1:62908538 A/G cg19896129 chr1:63156450 NA 0.44 6.84 0.35 3.76e-11 Triglyceride levels; CRC cis rs7208859 0.623 rs9900144 chr17:29208389 T/C cg13385521 chr17:29058706 SUZ12P 0.65 7.71 0.39 1.51e-13 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs6906287 0.573 rs12198461 chr6:118880640 T/G cg15382696 chr6:118971807 C6orf204 -0.33 -5.61 -0.3 4.31e-8 Electrocardiographic conduction measures; CRC cis rs1707322 0.721 rs28641748 chr1:46212836 A/G cg06784218 chr1:46089804 CCDC17 0.66 12.27 0.56 9.04e-29 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs10504229 1.000 rs17816781 chr8:58186161 A/T cg01721255 chr8:58191610 C8orf71 0.49 6.17 0.32 2e-9 Developmental language disorder (linguistic errors); CRC cis rs7923609 0.967 rs6479896 chr10:65126832 T/C cg08743896 chr10:65200160 JMJD1C -0.4 -5.74 -0.3 2.14e-8 Educational attainment;Liver enzyme levels (alkaline phosphatase); CRC cis rs2734839 0.964 rs12363125 chr11:113285916 C/T cg14159747 chr11:113255604 NA 0.48 8.46 0.42 9.17e-16 Information processing speed; CRC cis rs8060686 0.858 rs7196789 chr16:67927124 C/T cg26727032 chr16:67993705 SLC12A4 -0.73 -11.91 -0.55 1.93e-27 HDL cholesterol;Metabolic syndrome; CRC cis rs10416265 0.527 rs11084699 chr19:33538393 A/T cg17764715 chr19:33622953 WDR88 0.44 6.52 0.34 2.6200000000000003e-10 Bone properties (heel); CRC cis rs11190604 1.000 rs2489034 chr10:102319192 C/T cg16342193 chr10:102329863 NA -0.34 -5.79 -0.3 1.67e-8 Palmitoleic acid (16:1n-7) levels; CRC cis rs7208859 0.623 rs73271869 chr17:29152221 G/A cg13385521 chr17:29058706 SUZ12P 0.65 7.4 0.38 1.15e-12 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs3858526 0.959 rs10838797 chr11:5920977 A/G cg13902645 chr11:5959945 NA -0.64 -8.88 -0.44 4.37e-17 DNA methylation (variation); CRC cis rs6502050 0.805 rs6502061 chr17:80086158 C/T cg19223190 chr17:80058835 NA -0.39 -6.22 -0.32 1.52e-9 Life satisfaction; CRC cis rs2072510 0.569 rs7970524 chr12:96390152 A/G cg09636302 chr12:96389483 HAL -0.48 -6.36 -0.33 6.82e-10 Metabolite levels (small molecules and protein measures); CRC cis rs116248771 0.549 rs9849301 chr3:158444860 C/T cg16708174 chr3:158430962 RARRES1 0.44 5.79 0.3 1.67e-8 diarrhoeal disease at age 2; CRC cis rs4862750 0.872 rs13101408 chr4:187894777 G/A cg07414643 chr4:187882934 NA 0.38 6.64 0.34 1.33e-10 Lobe attachment (rater-scored or self-reported); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg06958567 chr18:52495541 RAB27B 0.43 6.42 0.33 4.69e-10 Response to antipsychotic treatment; CRC cis rs951366 0.617 rs823080 chr1:205789282 G/A cg24739457 chr1:205821442 NA 0.44 6.41 0.33 5.18e-10 Menarche (age at onset); CRC cis rs1801251 1.000 rs2305137 chr2:233712049 G/A cg25237894 chr2:233734115 C2orf82 -0.49 -8.03 -0.4 1.7e-14 Coronary artery disease; CRC trans rs877282 0.842 rs35117541 chr10:764683 C/T cg22713356 chr15:30763199 NA 1.29 15.31 0.65 2.44e-40 Uric acid levels; CRC cis rs644799 1.000 rs580255 chr11:95577929 T/C cg03916912 chr11:95522834 CEP57;FAM76B 0.96 18.56 0.72 4.06e-53 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg03741566 chr6:64346779 NA 0.41 6.3 0.33 9.58e-10 Liver disease severity in Alagille syndrome; CRC trans rs35110281 0.840 rs7276633 chr21:45078800 C/T cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.43 7.01 0.36 1.38e-11 Mean corpuscular volume; CRC cis rs6952808 1.000 rs4601204 chr7:1890925 C/T cg21782813 chr7:2030301 MAD1L1 0.45 7.44 0.38 8.57e-13 Bipolar disorder and schizophrenia; CRC cis rs7618915 0.547 rs11130317 chr3:52731483 C/T cg10802521 chr3:52805072 NEK4 -0.58 -8.89 -0.44 4.06e-17 Bipolar disorder; CRC trans rs7512552 0.966 rs1122967 chr1:150258838 C/G cg26040332 chr1:27960788 FGR 0.34 6.48 0.34 3.25e-10 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); CRC cis rs807669 0.903 rs1780640 chr22:19174597 C/T cg02655711 chr22:19163373 SLC25A1 0.98 19.99 0.74 9.58e-59 Metabolite levels; CRC cis rs7493 1.000 rs2299263 chr7:95040411 A/G cg17330251 chr7:94953956 PON1 0.57 7.36 0.38 1.46e-12 Yu-Zhi constitution type in type 2 diabetes; CRC trans rs4824093 0.544 rs73443951 chr22:50301251 C/T cg09872104 chr7:134855509 C7orf49 -0.72 -6.84 -0.35 3.83e-11 Amyotrophic lateral sclerosis (sporadic); CRC cis rs9462846 0.919 rs9471966 chr6:42891022 G/A cg21280719 chr6:42927975 GNMT -0.32 -5.96 -0.31 6.49e-9 Blood protein levels; CRC trans rs7615952 0.641 rs12487875 chr3:125787224 C/A cg07211511 chr3:129823064 LOC729375 -0.71 -9.73 -0.47 7.84e-20 Blood pressure (smoking interaction); CRC trans rs7819412 0.715 rs2409727 chr8:11043236 C/T cg06636001 chr8:8085503 FLJ10661 -0.44 -6.53 -0.34 2.52e-10 Triglycerides; CRC cis rs10927875 0.894 rs10927878 chr1:16319957 C/T cg10494257 chr1:16342123 HSPB7 -0.44 -5.9 -0.31 9.08e-9 Dilated cardiomyopathy; CRC cis rs3091242 0.935 rs4233043 chr1:25765483 A/G cg20684491 chr1:25596433 NA 0.42 7.29 0.37 2.32e-12 Erythrocyte sedimentation rate; CRC cis rs12681287 0.752 rs7846635 chr8:87304281 G/A cg27223183 chr8:87520930 FAM82B -0.44 -5.73 -0.3 2.22e-8 Caudate activity during reward; CRC cis rs57561814 0.510 rs2066992 chr7:22768249 G/T cg26061582 chr7:22766209 IL6 0.86 6.91 0.36 2.57e-11 Tonsillectomy; CRC cis rs7618915 0.547 rs8906 chr3:52739520 T/C cg07507251 chr3:52567010 NT5DC2 0.45 6.47 0.34 3.58e-10 Bipolar disorder; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg22466830 chr18:9475498 RALBP1 0.39 6.11 0.32 2.77e-9 Intelligence (multi-trait analysis); CRC cis rs6912958 0.712 rs7772561 chr6:88331299 A/G cg12350822 chr6:88032061 C6orf162;GJB7 -0.32 -6.01 -0.31 5e-9 Monocyte percentage of white cells; CRC cis rs3767633 0.925 rs4657103 chr1:161740483 G/T cg09175582 chr1:161736000 ATF6 0.67 6.1 0.32 2.91e-9 IgG glycosylation; CRC cis rs7618915 0.501 rs34754793 chr3:52629177 A/T cg15147215 chr3:52552868 STAB1 -0.63 -10.88 -0.51 9.7e-24 Bipolar disorder; CRC cis rs11971779 0.941 rs28395455 chr7:139035986 A/G cg07862535 chr7:139043722 LUC7L2 0.74 8.62 0.43 2.94e-16 Diisocyanate-induced asthma; CRC cis rs7208859 0.673 rs7211776 chr17:29120196 T/G cg14008862 chr17:28927542 LRRC37B2 0.51 6.01 0.31 4.88e-9 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC trans rs1265507 0.666 rs1862908 chr12:114871981 A/C cg11700868 chr17:38521232 GJD3 0.41 5.96 0.31 6.45e-9 Percent mammographic density; CRC cis rs1150668 0.699 rs2394049 chr6:28239681 A/G cg06470822 chr6:28175283 NA 0.52 7.7 0.39 1.63e-13 Pubertal anthropometrics; CRC cis rs875971 0.867 rs1002053 chr7:65798545 G/A cg00343986 chr7:65444356 GUSB -0.43 -6.24 -0.33 1.32e-9 Aortic root size; CRC cis rs853679 0.517 rs9295759 chr6:28124469 C/T cg23161317 chr6:28129485 ZNF389 0.53 6.43 0.33 4.52e-10 Depression; CRC cis rs4664304 1.000 rs3806603 chr2:160761808 T/C cg03641300 chr2:160917029 PLA2R1 -0.42 -5.89 -0.31 9.55e-9 Crohn's disease;Inflammatory bowel disease; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg11178321 chr12:9601031 DDX12 0.42 6.0 0.31 5.13e-9 Response to antipsychotic treatment; CRC cis rs6951245 1.000 rs78185558 chr7:1090183 G/C cg04025307 chr7:1156635 C7orf50 0.61 6.74 0.35 7.28e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs7705042 0.828 rs181826 chr5:141526057 C/A cg08523384 chr5:141488047 NDFIP1 -0.32 -5.71 -0.3 2.5e-8 Asthma; CRC cis rs727505 0.789 rs9641761 chr7:124735205 A/T cg23710748 chr7:124431027 NA -0.72 -12.35 -0.56 4.66e-29 Lewy body disease; CRC cis rs400736 0.602 rs7553544 chr1:8165719 C/T cg25007680 chr1:8021821 PARK7 -0.51 -6.12 -0.32 2.7e-9 Response to antidepressants and depression; CRC cis rs4790333 1.000 rs4790333 chr17:2262703 A/G cg02569219 chr17:2266849 SGSM2 -0.59 -10.1 -0.49 4.64e-21 Proinsulin levels; CRC cis rs13161895 1.000 rs248320 chr5:179432096 G/A cg02702477 chr5:179499311 RNF130 0.56 6.48 0.34 3.31e-10 LDL cholesterol; CRC cis rs7089973 0.872 rs3180654 chr10:116615045 T/C cg23260525 chr10:116636907 FAM160B1 0.31 6.73 0.35 7.51e-11 Bipolar disorder or attention deficit hyperactivity disorder; CRC cis rs2839186 1.000 rs2839186 chr21:47690068 C/T cg09417038 chr21:47716443 C21orf57 -0.42 -7.02 -0.36 1.29e-11 Testicular germ cell tumor; CRC cis rs2976388 0.632 rs2585139 chr8:143808175 C/G cg20041105 chr8:143859282 LYNX1 0.45 8.04 0.41 1.67e-14 Urinary tract infection frequency; CRC cis rs6951245 1.000 rs11770909 chr7:1086716 G/A cg03188948 chr7:1209495 NA 0.64 6.46 0.34 3.68e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs6831352 0.918 rs7670638 chr4:100059807 G/C cg12011299 chr4:100065546 ADH4 -0.5 -9.49 -0.46 5.01e-19 Alcohol dependence; CRC cis rs34779708 0.931 rs34375045 chr10:35362356 A/C cg03585969 chr10:35415529 CREM 0.65 8.64 0.43 2.46e-16 Inflammatory bowel disease;Crohn's disease; CRC cis rs4689388 0.819 rs12649341 chr4:6294759 G/A cg00701064 chr4:6280414 WFS1 0.75 13.24 0.59 2.21e-32 Type 2 diabetes and other traits;Type 2 diabetes; CRC cis rs6694672 0.867 rs5029273 chr1:197145382 C/G cg13682187 chr1:196946512 CFHR5 0.46 7.25 0.37 3.09e-12 Asthma; CRC cis rs12024301 0.557 rs74395504 chr1:183633411 G/T cg11505048 chr1:183622726 RGL1;APOBEC4 0.78 6.93 0.36 2.18e-11 Peripheral arterial disease (traffic-related air pollution interaction); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg19379625 chr4:71859087 DCK 0.44 6.17 0.32 2.03e-9 Response to antipsychotic treatment; CRC cis rs17095355 1.000 rs7905306 chr10:111712902 C/T cg00817464 chr10:111662876 XPNPEP1 -0.6 -8.09 -0.41 1.19e-14 Biliary atresia; CRC trans rs3733585 0.605 rs7656624 chr4:10121097 T/C cg26043149 chr18:55253948 FECH -0.56 -8.07 -0.41 1.35e-14 Cleft plate (environmental tobacco smoke interaction); CRC cis rs5750830 0.621 rs5750810 chr22:39792943 A/G cg25459000 chr22:39777742 SYNGR1 -0.33 -5.99 -0.31 5.58e-9 Intelligence (multi-trait analysis); CRC cis rs4268898 0.931 rs2551121 chr2:24539967 T/C cg06627628 chr2:24431161 ITSN2 -0.56 -8.32 -0.42 2.33e-15 Asthma; CRC cis rs4660306 1.000 rs11211132 chr1:45990516 T/C cg03123370 chr1:45965343 CCDC163P;MMACHC -0.55 -7.81 -0.4 7.94e-14 Homocysteine levels; CRC trans rs11738223 0.678 rs17654445 chr5:171925864 C/T cg27141267 chr11:66175971 NA -0.53 -6.6 -0.34 1.61e-10 Menopause (age at onset); CRC cis rs2034088 0.965 rs4968070 chr17:446162 A/G cg06217071 chr17:408420 NA 0.34 6.69 0.35 9.81e-11 Hip circumference adjusted for BMI; CRC cis rs3857536 0.776 rs4710583 chr6:66940101 A/C cg07460842 chr6:66804631 NA -0.43 -5.81 -0.3 1.48e-8 Blood trace element (Cu levels); CRC cis rs9372498 0.536 rs17080292 chr6:118850266 A/G cg07617317 chr6:118971624 C6orf204 0.5 6.26 0.33 1.22e-9 Diastolic blood pressure; CRC cis rs7937682 0.602 rs4936804 chr11:111743851 A/C cg19812747 chr11:111475976 SIK2 0.43 6.29 0.33 1.03e-9 Primary sclerosing cholangitis; CRC cis rs10504229 1.000 rs1390411 chr8:58194146 C/A cg02725872 chr8:58115012 NA -0.44 -7.88 -0.4 4.69e-14 Developmental language disorder (linguistic errors); CRC trans rs8002861 0.870 rs9567293 chr13:44447243 A/G cg17145862 chr1:211918768 LPGAT1 0.75 15.25 0.64 4.43e-40 Leprosy; CRC trans rs1814175 0.587 rs7948538 chr11:50021353 A/C cg03929089 chr4:120376271 NA -0.89 -15.93 -0.66 9.4e-43 Height; CRC cis rs1348850 0.918 rs4893966 chr2:178470138 A/G cg02961200 chr2:178257176 LOC100130691;AGPS 0.5 7.23 0.37 3.43e-12 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs951366 0.789 rs823137 chr1:205738302 C/T cg07167872 chr1:205819463 PM20D1 0.77 11.99 0.55 1.01e-27 Menarche (age at onset); CRC cis rs2075371 0.966 rs2544223 chr7:133995787 A/G cg11752832 chr7:134001865 SLC35B4 0.5 7.69 0.39 1.75e-13 Mean platelet volume; CRC cis rs938554 0.513 rs3775946 chr4:9995256 A/G cg11266682 chr4:10021025 SLC2A9 0.35 6.15 0.32 2.31e-9 Blood metabolite levels; CRC cis rs921968 0.565 rs7580147 chr2:219643036 A/G cg02176678 chr2:219576539 TTLL4 -0.41 -6.52 -0.34 2.63e-10 Mean corpuscular hemoglobin concentration; CRC cis rs2735413 0.914 rs1922608 chr16:78065139 A/G cg04733911 chr16:78082701 NA -0.37 -6.0 -0.31 5.22e-9 Systolic blood pressure (alcohol consumption interaction); CRC cis rs10256972 0.681 rs6979076 chr7:1116247 C/T cg22907277 chr7:1156413 C7orf50 -0.61 -9.21 -0.45 4.05e-18 Longevity;Endometriosis; CRC cis rs13418410 0.539 rs11695597 chr2:33840024 A/G cg04131969 chr2:33951647 MYADML 0.61 9.18 0.45 4.97e-18 Non-response to antidepressants and depression; CRC cis rs3733585 0.699 rs6856127 chr4:9965443 T/C cg00071950 chr4:10020882 SLC2A9 -0.54 -9.7 -0.47 1.02e-19 Cleft plate (environmental tobacco smoke interaction); CRC cis rs4665809 1.000 rs4665306 chr2:26319124 C/T cg04944784 chr2:26401820 FAM59B -0.6 -7.77 -0.39 1.01e-13 Gut microbiome composition (summer); CRC cis rs9467711 0.591 rs67844427 chr6:25931020 G/A cg16898833 chr6:26189333 HIST1H4D 0.69 5.83 0.31 1.34e-8 Autism spectrum disorder or schizophrenia; CRC cis rs9300255 0.782 rs12809602 chr12:123768916 T/G cg00376283 chr12:123451042 ABCB9 -0.52 -6.14 -0.32 2.44e-9 Neutrophil percentage of white cells; CRC cis rs875971 0.862 rs28491091 chr7:65669064 G/T cg12463550 chr7:65579703 CRCP -0.5 -6.75 -0.35 6.76e-11 Aortic root size; CRC cis rs554111 0.891 rs609880 chr1:21055891 A/G cg08890418 chr1:21044141 KIF17 0.32 6.0 0.31 5.28e-9 Facial morphology (factor 17, height of vermillion upper lip); CRC cis rs13191362 1.000 rs67487119 chr6:163102657 A/C cg14584255 chr6:163149320 PACRG;PARK2 0.44 6.39 0.33 5.65e-10 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs2243480 1.000 rs57057549 chr7:65405738 A/G cg25985355 chr7:65971099 NA -0.5 -5.86 -0.31 1.11e-8 Diabetic kidney disease; CRC cis rs17270561 0.583 rs6908713 chr6:25703611 G/A cg17691542 chr6:26056736 HIST1H1C -0.63 -8.01 -0.4 1.98e-14 Iron status biomarkers; CRC cis rs9322193 0.884 rs7743823 chr6:150170880 A/G cg13206674 chr6:150067644 NUP43 0.58 8.26 0.41 3.66e-15 Lung cancer; CRC cis rs10540 0.686 rs12421266 chr11:537120 C/T cg03576123 chr11:487126 PTDSS2 -1.0 -10.1 -0.49 4.63e-21 Body mass index; CRC cis rs6502050 0.835 rs8080625 chr17:80115447 G/A cg13198984 chr17:80129470 CCDC57 0.46 8.18 0.41 6.3e-15 Life satisfaction; CRC cis rs4954585 0.683 rs13004902 chr2:137027680 A/G cg05194412 chr2:137003533 NA 0.44 6.82 0.35 4.34e-11 Colorectal cancer; CRC cis rs4654899 1.000 rs7537072 chr1:21434533 T/C cg02927042 chr1:21476669 EIF4G3 -0.47 -7.65 -0.39 2.17e-13 Superior frontal gyrus grey matter volume; CRC cis rs8077889 0.672 rs4793028 chr17:41857212 T/C cg26893861 chr17:41843967 DUSP3 1.09 21.12 0.76 3.51e-63 Triglycerides; CRC cis rs7647973 1.000 rs10155014 chr3:49432321 C/T cg07636037 chr3:49044803 WDR6 0.66 8.27 0.41 3.29e-15 Menarche (age at onset); CRC cis rs9916302 0.904 rs6503503 chr17:37514373 G/A cg07936489 chr17:37558343 FBXL20 0.82 12.31 0.56 6.59e-29 Glomerular filtration rate (creatinine); CRC cis rs2735413 0.781 rs11649473 chr16:78077238 C/T cg04733911 chr16:78082701 NA -0.45 -7.5 -0.38 6.09e-13 Systolic blood pressure (alcohol consumption interaction); CRC cis rs7772486 0.654 rs702321 chr6:146006695 A/G cg05347473 chr6:146136440 FBXO30 -0.37 -5.65 -0.3 3.48e-8 Lobe attachment (rater-scored or self-reported); CRC cis rs3892630 0.588 rs28787932 chr19:33226229 T/C cg22980127 chr19:33182716 NUDT19 0.9 11.73 0.54 8.82e-27 Red blood cell traits; CRC cis rs6502050 0.835 rs8067875 chr17:80092778 C/T cg02741985 chr17:80059408 CCDC57 0.42 6.97 0.36 1.76e-11 Life satisfaction; CRC cis rs35883536 0.647 rs1335765 chr1:101048612 A/T cg06223162 chr1:101003688 GPR88 -0.34 -6.1 -0.32 2.96e-9 Monocyte count; CRC cis rs71403859 0.502 rs12927006 chr16:71549911 A/G cg08717414 chr16:71523259 ZNF19 -1.07 -11.0 -0.52 3.46e-24 Post bronchodilator FEV1; CRC cis rs7725052 0.609 rs67224409 chr5:40446876 T/C cg09067459 chr5:40385259 NA -0.4 -6.61 -0.34 1.53e-10 Pediatric autoimmune diseases; CRC cis rs1712517 0.744 rs4293063 chr10:105052976 G/T cg05636881 chr10:105038444 INA 0.47 8.08 0.41 1.23e-14 Migraine; CRC cis rs478304 0.593 rs7120713 chr11:65483374 G/C cg27068330 chr11:65405492 SIPA1 -0.65 -9.57 -0.47 2.68e-19 Acne (severe); CRC cis rs1799949 1.000 rs35330014 chr17:41212547 C/T cg19454999 chr17:41278357 BRCA1;NBR2 0.54 8.52 0.43 5.79e-16 Menopause (age at onset); CRC trans rs11098499 0.618 rs35265692 chr4:120325135 T/C cg25214090 chr10:38739885 LOC399744 0.67 10.18 0.49 2.46e-21 Corneal astigmatism; CRC cis rs9649213 0.593 rs6945554 chr7:97972946 T/C cg21770322 chr7:97807741 LMTK2 0.52 8.63 0.43 2.73e-16 Prostate cancer (SNP x SNP interaction); CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg09392819 chr2:26568944 SELI;GPR113 -0.4 -6.18 -0.32 1.9e-9 Myopia (pathological); CRC cis rs1843834 0.898 rs11887386 chr2:225526975 T/G cg22455342 chr2:225449267 CUL3 0.42 5.86 0.31 1.13e-8 IgE levels in asthmatics (D.p. specific); CRC cis rs2949837 0.655 rs11977526 chr7:46008110 G/A cg23193639 chr7:45961078 IGFBP3 0.49 7.96 0.4 2.79e-14 Sitting height ratio; CRC cis rs4665809 0.567 rs6546848 chr2:26444414 G/C cg26119090 chr2:26468346 HADHA;HADHB -1.0 -14.65 -0.63 8.89e-38 Gut microbiome composition (summer); CRC cis rs6860806 0.632 rs4330455 chr5:131586349 T/C cg20512303 chr5:131592959 PDLIM4 0.33 6.22 0.32 1.51e-9 Breast cancer; CRC cis rs7945705 0.869 rs11042154 chr11:9029700 A/G cg00186954 chr11:8933980 ST5;C11orf17 -0.38 -5.71 -0.3 2.48e-8 Hemoglobin concentration; CRC cis rs7586673 0.930 rs7591506 chr2:161960925 T/G cg22496339 chr2:162101262 NA 0.59 8.5 0.42 6.8e-16 Intelligence (multi-trait analysis); CRC cis rs2075371 1.000 rs2241334 chr7:133979225 C/G cg20476274 chr7:133979776 SLC35B4 0.82 15.01 0.64 3.87e-39 Mean platelet volume; CRC cis rs1499614 1.000 rs1638731 chr7:66144679 C/T cg18252515 chr7:66147081 NA -1.25 -14.86 -0.63 1.38e-38 Gout; CRC cis rs7044106 0.762 rs1470307 chr9:123433039 A/G cg09586646 chr9:123605570 PSMD5;LOC253039 0.6 8.8 0.44 8.09e-17 Hip circumference adjusted for BMI; CRC cis rs9467773 0.526 rs9348710 chr6:26360486 A/C cg09904177 chr6:26538194 HMGN4 -0.45 -6.33 -0.33 8.01e-10 Intelligence (multi-trait analysis); CRC cis rs10883723 0.810 rs6584508 chr10:104258567 A/G cg11453585 chr10:104263688 ACTR1A;SUFU 0.92 17.68 0.7 1.2e-49 Allergic disease (asthma, hay fever or eczema); CRC cis rs274567 0.501 rs272855 chr5:131687175 C/T cg27615366 chr5:131592974 PDLIM4 0.33 5.68 0.3 2.95e-8 Blood metabolite levels; CRC cis rs7737355 1.000 rs12521320 chr5:130755920 A/G cg06307176 chr5:131281290 NA -0.39 -5.91 -0.31 8.68e-9 Life satisfaction; CRC trans rs2303319 0.504 rs961421 chr2:162626099 G/C cg10498984 chr16:28874827 SH2B1 -0.73 -6.28 -0.33 1.04e-9 Cognitive function; CRC trans rs6550704 0.687 rs9865314 chr3:22634337 A/G cg16031283 chr22:20861701 MED15 -0.41 -6.0 -0.31 5.31e-9 Daytime sleep phenotypes; CRC cis rs17253792 0.545 rs34136598 chr14:56013238 C/T cg01858014 chr14:56050164 KTN1 -0.86 -6.23 -0.32 1.41e-9 Putamen volume; CRC cis rs13191362 0.507 rs2023038 chr6:163119280 C/G cg21926612 chr6:163149169 PACRG;PARK2 -0.49 -7.59 -0.39 3.37e-13 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs763121 0.853 rs5757234 chr22:39072686 C/T cg06544989 chr22:39130855 UNC84B 0.48 7.6 0.39 3.07e-13 Menopause (age at onset); CRC cis rs13108904 0.967 rs13109112 chr4:1290481 C/A cg21620606 chr4:1342894 KIAA1530 0.35 5.75 0.3 2.04e-8 Obesity-related traits; CRC cis rs2228479 0.557 rs12933317 chr16:89828220 A/G cg19635926 chr16:89946313 TCF25 0.63 5.68 0.3 2.97e-8 Skin colour saturation; CRC cis rs7591163 1.000 rs7574255 chr2:228699884 C/G cg20647610 chr2:228736258 WDR69 0.49 6.57 0.34 2.02e-10 Blood pressure; CRC cis rs2066819 1.000 rs17118439 chr12:56667604 C/T cg26714650 chr12:56694279 CS 1.41 11.73 0.54 8.68e-27 Psoriasis vulgaris; CRC cis rs7617773 0.963 rs6800730 chr3:48174210 C/T cg11946769 chr3:48343235 NME6 0.48 6.79 0.35 5.18e-11 Coronary artery disease; CRC cis rs12594515 0.967 rs11854477 chr15:45998345 A/C cg19682013 chr15:45996608 NA 0.29 5.88 0.31 9.88e-9 Waist circumference;Weight; CRC cis rs7666738 0.830 rs4699597 chr4:99019031 G/A cg17366294 chr4:99064904 C4orf37 0.43 7.29 0.37 2.28e-12 Colonoscopy-negative controls vs population controls; CRC cis rs6087990 0.806 rs910085 chr20:31383353 T/G cg13636640 chr20:31349939 DNMT3B 0.84 17.16 0.69 1.41e-47 Ulcerative colitis; CRC cis rs1580019 0.522 rs10951340 chr7:32562408 G/A cg07520158 chr7:32535189 LSM5;AVL9 0.53 7.74 0.39 1.2e-13 Cognitive ability; CRC cis rs10870270 0.956 rs7894 chr10:133769482 G/C cg17892150 chr10:133769511 PPP2R2D -0.74 -10.97 -0.52 4.45e-24 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; CRC cis rs1008375 0.932 rs7697329 chr4:17657853 C/A cg16339924 chr4:17578868 LAP3 0.59 7.41 0.38 1.07e-12 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs4664308 0.905 rs7567781 chr2:160999537 A/G cg03641300 chr2:160917029 PLA2R1 -0.74 -12.29 -0.56 7.62e-29 Idiopathic membranous nephropathy; CRC cis rs2067615 0.579 rs3782709 chr12:107205753 A/G cg13491945 chr12:107078410 RFX4 0.36 6.07 0.32 3.61e-9 Heart rate; CRC cis rs2976388 0.556 rs10956985 chr8:143818750 C/A cg04969067 chr8:143858791 LYNX1 -0.42 -6.2 -0.32 1.7e-9 Urinary tract infection frequency; CRC cis rs9660992 0.573 rs12144980 chr1:205185104 C/T cg00857998 chr1:205179979 DSTYK 0.43 5.68 0.3 2.9e-8 Mean corpuscular volume;Mean platelet volume; CRC cis rs344364 0.511 rs1742472 chr16:1953040 A/G cg09830162 chr16:1889614 FAHD1;C16orf73 -0.71 -8.96 -0.44 2.53e-17 Glomerular filtration rate in chronic kidney disease; CRC cis rs9381040 0.655 rs2294695 chr6:41036770 A/G cg04346459 chr6:41068666 NFYA;LOC221442 -0.4 -5.88 -0.31 9.89e-9 Alzheimer's disease (late onset); CRC cis rs4964805 0.581 rs7312825 chr12:104188388 G/C cg02344784 chr12:104178138 NT5DC3 0.79 15.0 0.64 4.21e-39 Attention deficit hyperactivity disorder; CRC cis rs597539 0.690 rs7129960 chr11:68622456 A/G cg21963583 chr11:68658836 MRPL21 0.6 10.28 0.49 1.15e-21 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs2976388 0.609 rs2717603 chr8:143803193 T/C cg15511327 chr8:143859410 LYNX1 0.39 6.87 0.35 3.13e-11 Urinary tract infection frequency; CRC cis rs1443512 0.796 rs1822437 chr12:54340077 A/G cg25382128 chr12:54346509 NA 0.39 5.71 0.3 2.47e-8 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for BMI in non-smokers;Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction);Waist-hip ratio;Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour); CRC cis rs3820068 0.603 rs72647128 chr1:15963908 T/C cg13390004 chr1:15929781 NA 0.5 7.07 0.36 9.19e-12 Systolic blood pressure; CRC trans rs6703335 0.870 rs10803142 chr1:243598234 A/G cg01719895 chr7:2443748 CHST12 0.44 6.05 0.32 3.94e-9 Schizophrenia;Schizophrenia, schizoaffective disorder or bipolar disorder; CRC cis rs6499255 0.951 rs7196943 chr16:69592449 T/A cg15192750 chr16:69999425 NA 0.57 7.64 0.39 2.43e-13 IgE levels; CRC cis rs1552244 0.744 rs6763366 chr3:10033544 T/C cg18598329 chr3:10140678 FANCD2;C3orf24 -0.81 -10.69 -0.51 4.35e-23 Alzheimer's disease; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg13986249 chr9:37903631 MCART1 0.4 6.13 0.32 2.45e-9 Liver disease severity in Alagille syndrome; CRC cis rs694739 1.000 rs11231757 chr11:64106317 C/T cg02228329 chr11:64053129 BAD;GPR137 0.6 8.96 0.44 2.41e-17 Alopecia areata;Crohn's disease;Psoriasis vulgaris; CRC cis rs910316 1.000 rs10873275 chr14:75531460 A/T cg08847533 chr14:75593920 NEK9 0.94 18.0 0.7 6.39e-51 Height; CRC cis rs2535633 0.631 rs2581803 chr3:52994981 G/A cg11645453 chr3:52864694 ITIH4 -0.41 -7.71 -0.39 1.55e-13 Body mass index; CRC cis rs7258465 1.000 rs3810429 chr19:18543270 G/T cg10790698 chr19:18539756 SSBP4 -0.45 -8.43 -0.42 1.1e-15 Breast cancer; CRC cis rs4481887 0.861 rs4309013 chr1:248480768 C/T cg00666640 chr1:248458726 OR2T12 0.49 8.27 0.41 3.45e-15 Common traits (Other); CRC trans rs1455244 0.700 rs7229302 chr18:11508904 G/T cg06087298 chr1:118149316 FAM46C 0.42 6.52 0.34 2.72e-10 Schizophrenia; CRC cis rs67311347 0.866 rs56331709 chr3:40356558 A/C cg09455208 chr3:40491958 NA 0.36 6.81 0.35 4.57e-11 Renal cell carcinoma; CRC cis rs9914988 0.943 rs4313850 chr17:27080768 T/C cg20469991 chr17:27169893 C17orf63 -0.6 -7.23 -0.37 3.41e-12 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs7202877 0.706 rs247450 chr16:75490017 C/A cg03315344 chr16:75512273 CHST6 -0.55 -6.28 -0.33 1.06e-9 Type 2 diabetes;Type 1 diabetes; CRC cis rs1878931 0.535 rs10852706 chr16:3412582 G/C cg02880119 chr16:3481970 NA -0.41 -5.8 -0.3 1.57e-8 Body mass index (adult); CRC cis rs780096 0.587 rs6743819 chr2:27567407 G/T cg21248554 chr2:27665150 KRTCAP3 -0.28 -6.52 -0.34 2.58e-10 Total body bone mineral density; CRC cis rs1707322 0.964 rs6697830 chr1:46290477 C/A cg03146154 chr1:46216737 IPP 0.52 7.3 0.37 2.22e-12 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg22949881 chr12:9601149 DDX12 0.48 6.85 0.35 3.67e-11 Response to antipsychotic treatment; CRC cis rs4964805 0.594 rs3751204 chr12:104171455 C/T cg02344784 chr12:104178138 NT5DC3 0.44 6.72 0.35 7.85e-11 Attention deficit hyperactivity disorder; CRC cis rs10504229 0.683 rs16921817 chr8:58107563 A/T cg22535103 chr8:58192502 C8orf71 -0.69 -8.8 -0.44 7.79e-17 Developmental language disorder (linguistic errors); CRC cis rs394563 0.781 rs61516098 chr6:149794289 A/T cg07828024 chr6:149772892 ZC3H12D -0.49 -8.49 -0.42 7.11e-16 Dupuytren's disease; CRC cis rs720844 0.684 rs16828836 chr2:149312728 A/G cg09247360 chr2:149335327 NA -0.58 -6.04 -0.32 4.12e-9 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs1046896 1.000 rs9909940 chr17:80689036 C/T cg19500275 chr17:80737654 TBCD 0.39 5.91 0.31 8.71e-9 Glycated hemoglobin levels; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg01973771 chr19:2740143 SLC39A3 0.48 6.75 0.35 6.83e-11 Response to antipsychotic treatment; CRC cis rs1005224 0.853 rs6574251 chr14:76136883 C/T cg25116370 chr14:76127843 TTLL5;C14orf1 -0.45 -7.23 -0.37 3.4e-12 Large artery stroke; CRC cis rs7727544 0.507 rs11741341 chr5:131570218 A/G cg12564285 chr5:131593104 PDLIM4 0.53 9.97 0.48 1.25e-20 Blood metabolite levels; CRC cis rs9818758 0.607 rs34823813 chr3:49749976 G/A cg00383909 chr3:49044727 WDR6 1.45 12.72 0.57 2.09e-30 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; CRC cis rs2985684 0.895 rs4900940 chr14:50075310 A/C cg23565292 chr14:50234668 KLHDC2 -0.42 -5.78 -0.3 1.75e-8 Carotid intima media thickness; CRC cis rs4713118 0.955 rs9468201 chr6:27687035 C/T cg15845792 chr6:28175446 NA 0.6 7.91 0.4 3.82e-14 Parkinson's disease; CRC cis rs7584330 0.554 rs13411613 chr2:238437560 T/C cg14458575 chr2:238380390 NA 0.52 6.78 0.35 5.58e-11 Prostate cancer; CRC cis rs7945705 0.782 rs2742545 chr11:8884308 C/G cg12365402 chr11:9010492 NRIP3 -0.51 -9.1 -0.45 8.74e-18 Hemoglobin concentration; CRC cis rs13253111 0.603 rs28605937 chr8:28099179 A/G cg26534493 chr8:28060551 NA 0.41 7.17 0.37 4.87e-12 Childhood body mass index; CRC cis rs1728785 0.818 rs1814299 chr16:68581332 G/A cg02972257 chr16:68554789 NA -0.58 -7.24 -0.37 3.21e-12 Ulcerative colitis; CRC cis rs7927771 0.931 rs12361256 chr11:47910823 A/C cg18512352 chr11:47633146 NA -0.43 -8.47 -0.42 8.36e-16 Subjective well-being; CRC cis rs1355223 0.583 rs2941043 chr11:34870994 A/G cg11058730 chr11:34937778 PDHX;APIP -0.72 -11.61 -0.54 2.33e-26 Systemic lupus erythematosus and Systemic sclerosis; CRC cis rs910316 0.763 rs175450 chr14:75590340 G/A cg11812906 chr14:75593930 NEK9 -0.54 -8.33 -0.42 2.28e-15 Height; CRC trans rs9329221 0.650 rs657913 chr8:9882575 G/T cg06636001 chr8:8085503 FLJ10661 -0.54 -8.24 -0.41 4.12e-15 Neuroticism; CRC cis rs6500395 1.000 rs8058362 chr16:48645316 T/C cg04672837 chr16:48644449 N4BP1 0.44 6.4 0.33 5.42e-10 Response to tocilizumab in rheumatoid arthritis; CRC cis rs2180341 0.532 rs6933893 chr6:127707250 A/G cg27446573 chr6:127587934 RNF146 0.62 9.1 0.45 8.93e-18 Breast cancer; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg05609751 chr17:4269695 UBE2G1 0.43 6.24 0.33 1.31e-9 Intelligence (multi-trait analysis); CRC trans rs7267979 1.000 rs2424704 chr20:25273929 A/G cg17903999 chr18:56338584 MALT1 -0.42 -6.96 -0.36 1.84e-11 Liver enzyme levels (alkaline phosphatase); CRC cis rs2067615 0.524 rs10467029 chr12:107078448 C/T cg13491945 chr12:107078410 RFX4 0.36 6.19 0.32 1.8e-9 Heart rate; CRC cis rs4713118 0.513 rs149972 chr6:27983227 C/T cg02683197 chr6:28174875 NA 0.63 8.67 0.43 2.06e-16 Parkinson's disease; CRC cis rs7666738 0.830 rs10031190 chr4:98908683 C/A cg17366294 chr4:99064904 C4orf37 0.42 6.93 0.36 2.24e-11 Colonoscopy-negative controls vs population controls; CRC cis rs2439831 0.681 rs28578454 chr15:43603032 G/A cg15269541 chr15:43626905 ADAL -0.55 -6.36 -0.33 6.56e-10 Lung cancer in ever smokers; CRC cis rs595982 0.559 rs17206714 chr19:49362001 T/A cg21252483 chr19:49399788 TULP2 -0.36 -5.69 -0.3 2.88e-8 Red cell distribution width; CRC trans rs7615952 0.512 rs11929125 chr3:125359443 G/A cg03844506 chr4:4109441 NA -0.51 -7.57 -0.39 3.88e-13 Blood pressure (smoking interaction); CRC cis rs9818758 0.607 rs11716445 chr3:49406095 C/T cg01304814 chr3:48885189 PRKAR2A 0.87 6.46 0.34 3.69e-10 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; CRC cis rs7802263 0.876 rs4731204 chr7:124383834 G/A cg23710748 chr7:124431027 NA -0.39 -5.64 -0.3 3.63e-8 Reading and spelling; CRC cis rs1003719 0.591 rs2835633 chr21:38525019 G/A cg10648535 chr21:38446584 PIGP;TTC3 -0.44 -6.18 -0.32 1.87e-9 Eye color traits; CRC cis rs873946 0.504 rs12775990 chr10:134575836 C/T cg18305652 chr10:134549665 INPP5A 0.49 6.58 0.34 1.83e-10 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CRC cis rs1008375 1.000 rs4698198 chr4:17656536 G/A cg04450456 chr4:17643702 FAM184B 0.41 6.59 0.34 1.79e-10 Parasitemia in Tripanosoma cruzi seropositivity; CRC trans rs11098499 0.954 rs13133522 chr4:120324424 A/T cg25214090 chr10:38739885 LOC399744 0.66 10.47 0.5 2.41e-22 Corneal astigmatism; CRC cis rs2032447 0.869 rs2230655 chr6:26033506 A/G cg17691542 chr6:26056736 HIST1H1C -0.41 -5.66 -0.3 3.27e-8 Intelligence (multi-trait analysis); CRC cis rs35883536 1.000 rs2297715 chr1:101092594 A/G cg14515779 chr1:101123966 NA -0.43 -8.39 -0.42 1.49e-15 Monocyte count; CRC cis rs891088 0.677 rs11670892 chr19:7185306 C/G cg00428638 chr19:7224713 INSR -0.59 -6.17 -0.32 1.99e-9 Hip circumference adjusted for BMI;Height; CRC cis rs7659604 0.539 rs3217773 chr4:122739121 A/G cg06713675 chr4:122721982 EXOSC9 -0.51 -8.31 -0.42 2.54e-15 Type 2 diabetes; CRC cis rs2180341 0.961 rs910720 chr6:127619070 T/C cg27446573 chr6:127587934 RNF146 0.99 14.76 0.63 3.48e-38 Breast cancer; CRC cis rs9768139 0.901 rs56113702 chr7:158117938 C/T cg24154853 chr7:158122151 PTPRN2 -0.59 -9.9 -0.48 2.06e-20 Calcium levels; CRC cis rs6502050 0.814 rs9894554 chr17:80073423 C/G cg09264619 chr17:80180166 NA 0.37 6.16 0.32 2.08e-9 Life satisfaction; CRC cis rs9733 0.596 rs2867301 chr1:150653795 C/T cg15448220 chr1:150897856 SETDB1 0.45 6.43 0.33 4.42e-10 Tonsillectomy; CRC cis rs12926788 0.640 rs73551577 chr16:24845143 G/A cg04756594 chr16:24857601 SLC5A11 0.31 6.35 0.33 7.32e-10 Ejection fraction in Tripanosoma cruzi seropositivity; CRC cis rs9914988 0.943 rs11651867 chr17:27147248 T/G cg07195577 chr17:27052828 TLCD1 0.41 5.92 0.31 7.89e-9 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs9368481 1.000 rs9368481 chr6:26961761 C/T cg18278486 chr6:26987575 LOC100270746;C6orf41 -0.48 -7.39 -0.38 1.21e-12 Autism spectrum disorder or schizophrenia; CRC cis rs13082711 0.554 rs34066402 chr3:27387987 G/A cg02860705 chr3:27208620 NA 0.85 10.95 0.52 5.53e-24 Systolic blood pressure;Diastolic blood pressure;Blood pressure; CRC cis rs992157 0.560 rs12987130 chr2:219104990 T/C cg04731861 chr2:219085781 ARPC2 0.37 7.94 0.4 3.26e-14 Colorectal cancer; CRC cis rs9325144 0.555 rs4882359 chr12:38726679 T/C cg13010199 chr12:38710504 ALG10B 0.4 5.82 0.31 1.43e-8 Morning vs. evening chronotype; CRC trans rs7395662 0.591 rs4882233 chr11:48739653 A/G cg00717180 chr2:96193071 NA -0.38 -6.25 -0.33 1.27e-9 HDL cholesterol; CRC cis rs10504229 0.683 rs11786527 chr8:58131344 G/C cg02290350 chr8:58132656 NA -0.56 -7.77 -0.39 1.02e-13 Developmental language disorder (linguistic errors); CRC cis rs1656402 0.906 rs1190436 chr2:233424096 G/A cg03852847 chr2:233439513 NA 0.46 7.87 0.4 5.19e-14 Non-small cell lung cancer (survival); CRC cis rs728616 0.867 rs55835350 chr10:81801728 A/T cg05935833 chr10:81318306 SFTPA2 -0.58 -6.82 -0.35 4.41e-11 Chronic obstructive pulmonary disease-related biomarkers; CRC trans rs7613875 0.641 rs6446194 chr3:50067298 T/A cg21659725 chr3:3221576 CRBN -0.46 -6.88 -0.35 2.99e-11 Body mass index; CRC cis rs875971 1.000 rs7792762 chr7:66004138 T/C cg18912574 chr7:65842487 NCRNA00174 0.36 6.02 0.31 4.69e-9 Aortic root size; CRC trans rs2727020 0.576 rs1917321 chr11:49377760 A/C cg15704280 chr7:45808275 SEPT13 -0.67 -10.27 -0.49 1.21e-21 Coronary artery disease; CRC cis rs10504229 0.683 rs2088217 chr8:58113124 C/T cg02290350 chr8:58132656 NA -0.6 -8.3 -0.42 2.8e-15 Developmental language disorder (linguistic errors); CRC cis rs12220238 1.000 rs11000924 chr10:75972311 T/A cg19889307 chr10:75911429 ADK;AP3M1 0.54 5.61 0.3 4.26e-8 Soluble interleukin-2 receptor subunit alpha; CRC cis rs4268898 0.662 rs714531 chr2:24399877 G/A cg06627628 chr2:24431161 ITSN2 -0.86 -11.67 -0.54 1.45e-26 Asthma; CRC cis rs12142240 0.698 rs67487250 chr1:46811333 T/C cg00530320 chr1:46809349 NSUN4 0.58 7.8 0.4 8.18e-14 Menopause (age at onset); CRC cis rs172166 0.652 rs476167 chr6:28065888 T/C cg12273811 chr6:28175739 NA 0.62 9.07 0.45 1.1e-17 Cardiac Troponin-T levels; CRC cis rs7731657 0.537 rs10073487 chr5:130373397 G/A cg08523029 chr5:130500466 HINT1 -0.45 -5.87 -0.31 1.06e-8 Fasting plasma glucose; CRC cis rs7552404 0.727 rs2172508 chr1:76320215 A/G cg10523679 chr1:76189770 ACADM 0.71 8.94 0.44 2.88e-17 Blood metabolite levels;Acylcarnitine levels; CRC trans rs2228479 1.000 rs11642267 chr16:89957635 T/C cg21302420 chr1:112162376 RAP1A 0.83 7.41 0.38 1.07e-12 Skin colour saturation; CRC cis rs4975709 0.589 rs4975707 chr5:1864028 C/T cg15595755 chr5:1867978 NA 0.38 6.34 0.33 7.54e-10 Cardiovascular disease risk factors; CRC trans rs9858542 1.000 rs13085791 chr3:49721798 C/A cg21659725 chr3:3221576 CRBN -0.72 -9.53 -0.47 3.66e-19 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs17401966 0.838 rs4333852 chr1:10387704 A/T cg19773385 chr1:10388646 KIF1B 0.64 10.23 0.49 1.6e-21 Hepatocellular carcinoma; CRC cis rs873946 0.529 rs12258248 chr10:134573767 A/G cg18305652 chr10:134549665 INPP5A 0.53 7.72 0.39 1.38e-13 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CRC cis rs7945705 0.818 rs2742537 chr11:8908389 G/A cg21881798 chr11:8931708 C11orf17;ST5 -0.72 -12.75 -0.57 1.6e-30 Hemoglobin concentration; CRC cis rs7811142 0.830 rs73401443 chr7:99977582 T/G cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.76 10.68 0.51 4.55e-23 Platelet count; CRC cis rs1707322 1.000 rs10890380 chr1:46449469 A/G cg06784218 chr1:46089804 CCDC17 0.51 8.94 0.44 2.91e-17 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs17065868 0.764 rs60560319 chr13:45039622 G/A cg10246903 chr13:45222710 NA 0.54 5.69 0.3 2.79e-8 Antineutrophil cytoplasmic antibody-associated vasculitis; CRC cis rs78456975 1.000 rs10192959 chr2:1553393 G/T cg12573674 chr2:1569213 NA -0.76 -7.84 -0.4 6.48e-14 Placebo response in major depressive disorder (% change in symptom score); CRC cis rs1707322 0.928 rs10732844 chr1:46372688 T/C cg06784218 chr1:46089804 CCDC17 0.52 9.12 0.45 7.88e-18 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs13217239 0.646 rs35691005 chr6:26972070 A/G cg18867708 chr6:26865862 GUSBL1 0.38 5.82 0.31 1.39e-8 Schizophrenia; CRC cis rs9322193 0.962 rs9765929 chr6:150090816 T/C cg13206674 chr6:150067644 NUP43 0.57 8.19 0.41 5.85e-15 Lung cancer; CRC cis rs10504229 0.683 rs7817188 chr8:58129549 C/T cg04204079 chr8:58130323 NA -0.45 -5.78 -0.3 1.71e-8 Developmental language disorder (linguistic errors); CRC cis rs10992471 0.603 rs4744137 chr9:95288352 G/A cg14631576 chr9:95140430 CENPP -0.39 -6.76 -0.35 6.18e-11 Visceral adipose tissue/subcutaneous adipose tissue ratio; CRC cis rs9325144 0.600 rs6582634 chr12:38748041 G/A cg26384229 chr12:38710491 ALG10B 0.54 7.86 0.4 5.55e-14 Morning vs. evening chronotype; CRC cis rs5750830 0.546 rs4821891 chr22:39785381 C/T cg25956985 chr22:39795188 MAP3K7IP1 -0.4 -5.79 -0.3 1.68e-8 Intelligence (multi-trait analysis); CRC cis rs7312933 0.533 rs3747557 chr12:42717961 G/T cg11827402 chr12:42719852 PPHLN1;ZCRB1 -0.63 -9.23 -0.45 3.51e-18 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CRC trans rs9291683 0.552 rs17187075 chr4:9990328 G/C cg26043149 chr18:55253948 FECH 0.5 7.76 0.39 1.1e-13 Bone mineral density; CRC cis rs4984778 0.750 rs7198064 chr16:1272472 C/T cg07748719 chr16:1272498 TPSG1 0.56 9.04 0.45 1.34e-17 Blood protein levels; CRC cis rs7666738 0.830 rs13136930 chr4:98937933 A/T cg05340658 chr4:99064831 C4orf37 0.6 9.35 0.46 1.41e-18 Colonoscopy-negative controls vs population controls; CRC trans rs7395662 0.591 rs4882085 chr11:48504569 C/G cg21153622 chr11:89784906 NA -0.5 -8.34 -0.42 2.08e-15 HDL cholesterol; CRC cis rs62458065 0.713 rs1597560 chr7:32493886 C/G cg20159608 chr7:32802032 NA -0.56 -7.35 -0.38 1.59e-12 Metabolite levels (HVA/MHPG ratio); CRC cis rs769267 0.930 rs1054930 chr19:19648346 G/C cg03709012 chr19:19516395 GATAD2A 0.72 11.2 0.53 6.75e-25 Tonsillectomy; CRC cis rs992157 1.000 rs13429408 chr2:219142860 C/A cg20019365 chr2:219134978 PNKD;AAMP 0.39 5.96 0.31 6.5e-9 Colorectal cancer; CRC cis rs740160 0.558 rs73395508 chr7:98901894 A/C cg24650262 chr7:98904301 NA 0.55 5.72 0.3 2.33e-8 Dehydroepiandrosterone sulphate levels; CRC trans rs2727020 0.521 rs11039902 chr11:48679467 A/G cg03929089 chr4:120376271 NA -0.49 -7.08 -0.36 8.84e-12 Coronary artery disease; CRC cis rs9427116 0.967 rs7547072 chr1:154639255 A/G cg17218026 chr1:154582156 ADAR -0.39 -6.03 -0.32 4.5e-9 Blood protein levels; CRC cis rs11645898 0.748 rs56387295 chr16:72055336 C/A cg14768367 chr16:72042858 DHODH -0.76 -7.69 -0.39 1.7e-13 Blood protein levels; CRC trans rs4942242 0.663 rs17460812 chr13:44215504 A/G cg19169023 chr15:41853346 TYRO3 -0.58 -8.6 -0.43 3.36e-16 Response to tocilizumab in rheumatoid arthritis; CRC cis rs9640161 0.659 rs11974980 chr7:150009838 C/T cg12556325 chr7:150026731 C7orf29;LRRC61 -0.43 -6.59 -0.34 1.75e-10 Blood protein levels;Circulating chemerin levels; CRC cis rs597539 0.652 rs646586 chr11:68681653 C/T cg11716795 chr11:68671300 MRPL21;IGHMBP2 -0.8 -13.34 -0.59 9.22e-33 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC trans rs2303319 0.504 rs62189043 chr2:162608466 A/T cg23919916 chr10:103825097 HPS6 -0.69 -6.01 -0.31 4.8e-9 Cognitive function; CRC cis rs9296092 0.560 rs3846853 chr6:33528194 C/G cg13560919 chr6:33536144 NA -0.44 -6.28 -0.33 1.09e-9 Age at smoking initiation in chronic obstructive pulmonary disease; CRC cis rs2576037 0.583 rs4890698 chr18:44489725 A/G cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.56 -8.52 -0.43 5.86e-16 Personality dimensions; CRC cis rs1465370 0.720 rs7811463 chr7:130017488 G/A cg03229158 chr7:130009420 NA 0.43 6.06 0.32 3.78e-9 Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction);Waist circumference adjusted for BMI in active individuals;Waist circumference adjusted for body mass index; CRC cis rs11711311 1.000 rs1043132 chr3:113528689 A/C cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.53 -7.2 -0.37 4.13e-12 IgG glycosylation; CRC cis rs1882538 0.551 rs6974618 chr7:133084031 C/A cg10665199 chr7:133106180 EXOC4 0.64 9.82 0.48 4e-20 Intelligence (multi-trait analysis); CRC cis rs4819052 0.851 rs1006779 chr21:46670752 A/G cg11663144 chr21:46675770 NA -0.71 -11.55 -0.54 3.76e-26 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs644799 0.672 rs61902245 chr11:95517737 C/T cg25622487 chr11:95524042 FAM76B;CEP57 0.8 13.24 0.59 2.21e-32 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs12477438 0.765 rs7607578 chr2:99669771 G/A cg14399236 chr2:99771627 LIPT1;TSGA10 -0.6 -8.19 -0.41 6.03e-15 Chronic sinus infection; CRC cis rs875971 1.000 rs6970030 chr7:65968679 T/C cg18912574 chr7:65842487 NCRNA00174 0.35 6.09 0.32 3.11e-9 Aortic root size; CRC cis rs780096 0.526 rs1260342 chr2:27663416 G/T cg17158414 chr2:27665306 KRTCAP3 -0.31 -6.75 -0.35 6.85e-11 Total body bone mineral density; CRC cis rs9303280 0.806 rs35569035 chr17:38035624 C/T cg00129232 chr17:37814104 STARD3 -0.47 -7.44 -0.38 9.14e-13 Self-reported allergy; CRC cis rs2108622 0.727 rs62106158 chr19:15980492 T/G cg13772218 chr19:15982569 NA 0.48 6.82 0.35 4.37e-11 Circulating phylloquinone levels;Vitamin E levels;Acenocoumarol maintenance dosage;Response to Vitamin E supplementation;Metabolite levels;Warfarin maintenance dose; CRC trans rs5756813 0.727 rs58765732 chr22:38160794 A/C cg19894588 chr14:64061835 NA -0.59 -7.97 -0.4 2.64e-14 Optic cup area;Vertical cup-disc ratio; CRC cis rs9322193 0.923 rs9479494 chr6:150060244 A/G cg07701084 chr6:150067640 NUP43 0.61 9.04 0.45 1.41e-17 Lung cancer; CRC cis rs4713118 0.869 rs9348775 chr6:27695329 C/T cg12172441 chr6:28176163 NA 0.52 7.17 0.37 5.07e-12 Parkinson's disease; CRC trans rs2303319 0.504 rs56039028 chr2:162516363 G/A cg18122310 chr12:50236657 BCDIN3D -0.74 -6.19 -0.32 1.81e-9 Cognitive function; CRC cis rs10504229 0.639 rs66667899 chr8:58117065 C/T cg05313129 chr8:58192883 C8orf71 -0.43 -6.11 -0.32 2.74e-9 Developmental language disorder (linguistic errors); CRC cis rs2204008 0.744 rs11181337 chr12:38322083 C/A cg13010199 chr12:38710504 ALG10B 0.48 6.95 0.36 1.98e-11 Bladder cancer; CRC cis rs1005224 0.853 rs12898082 chr14:76306359 A/C cg04684003 chr14:76127793 TTLL5;C14orf1 0.44 6.38 0.33 6.12e-10 Large artery stroke; CRC trans rs10983614 1.000 rs7867776 chr9:120072627 A/G cg18579396 chr17:41623924 ETV4 0.43 6.01 0.31 4.91e-9 Survival in pancreatic cancer; CRC cis rs4563143 0.675 rs73029050 chr19:29276554 G/T cg03161606 chr19:29218774 NA 0.54 6.81 0.35 4.56e-11 Methadone dose in opioid dependence; CRC cis rs1448094 0.512 rs2405632 chr12:86252456 A/G cg25456477 chr12:86230367 RASSF9 0.33 5.85 0.31 1.17e-8 Major depressive disorder; CRC trans rs3960554 0.932 rs60717745 chr7:75846083 C/G cg19862616 chr7:65841803 NCRNA00174 0.68 7.47 0.38 7.25e-13 Eotaxin levels; CRC cis rs6662572 0.737 rs4660330 chr1:46458298 A/G cg03123370 chr1:45965343 CCDC163P;MMACHC -0.44 -5.69 -0.3 2.86e-8 Blood protein levels; CRC cis rs9467773 0.967 rs6924865 chr6:26521353 A/G cg09904177 chr6:26538194 HMGN4 0.86 14.74 0.63 4.11e-38 Intelligence (multi-trait analysis); CRC cis rs6546324 1.000 rs6546324 chr2:67856490 A/C cg15745817 chr2:67799979 NA -0.29 -5.83 -0.31 1.35e-8 Endometriosis; CRC cis rs7215564 0.908 rs35374347 chr17:78642244 C/T cg09596252 chr17:78655493 RPTOR 0.63 5.78 0.3 1.69e-8 Myopia (pathological); CRC cis rs2797160 0.967 rs1739358 chr6:126019736 G/A cg05901451 chr6:126070800 HEY2 0.4 6.02 0.32 4.63e-9 Endometrial cancer; CRC cis rs2658782 0.950 rs2446061 chr11:93149277 C/T cg15737290 chr11:93063684 CCDC67 0.52 7.54 0.38 4.47e-13 Pulmonary function decline; CRC cis rs6860806 0.507 rs635620 chr5:131720263 A/G cg18301423 chr5:131593218 PDLIM4 -0.39 -6.56 -0.34 2.14e-10 Breast cancer; CRC cis rs2153535 0.580 rs9406167 chr6:8502852 T/C cg21535247 chr6:8435926 SLC35B3 0.47 7.23 0.37 3.47e-12 Motion sickness; CRC cis rs2033908 0.620 rs7113256 chr11:12845849 T/C cg25843174 chr11:12811716 TEAD1 -0.42 -7.38 -0.38 1.26e-12 Sitting height ratio; CRC cis rs12681287 0.604 rs28378899 chr8:87434500 G/C cg27223183 chr8:87520930 FAM82B 0.52 7.36 0.38 1.45e-12 Caudate activity during reward; CRC cis rs748404 0.660 rs2467742 chr15:43750237 C/A cg02155558 chr15:43621948 ADAL;LCMT2 0.53 7.69 0.39 1.76e-13 Lung cancer; CRC cis rs460214 0.539 rs55819392 chr21:40038207 G/A cg21578987 chr21:40029669 ERG 0.42 6.0 0.31 5.3300000000000004e-09 Response to cognitive-behavioural therapy in anxiety disorder; CRC cis rs362272 0.545 rs2749783 chr4:3326098 A/C cg11522145 chr4:3412961 RGS12 -0.41 -6.63 -0.34 1.37e-10 Serum sulfate level; CRC cis rs4466137 0.794 rs6869296 chr5:83007333 C/G cg15083037 chr5:83017644 HAPLN1 0.51 7.46 0.38 7.65e-13 Prostate cancer; CRC cis rs4713118 0.539 rs510987 chr6:27847517 G/A cg15786705 chr6:28176104 NA 0.54 7.38 0.38 1.28e-12 Parkinson's disease; CRC cis rs12291225 0.585 rs10832242 chr11:14340504 C/T cg05501817 chr11:14380813 RRAS2 0.46 6.49 0.34 3.07e-10 Sense of smell; CRC cis rs13256369 0.802 rs4840350 chr8:8561442 A/G cg18904891 chr8:8559673 CLDN23 0.52 6.91 0.36 2.51e-11 Obesity-related traits; CRC cis rs9747201 0.894 rs9944398 chr17:80177439 A/G cg23141183 chr17:80185318 SLC16A3 0.43 6.04 0.32 4.08e-9 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs6570726 0.791 rs12205752 chr6:145896118 A/G cg13319975 chr6:146136371 FBXO30 -0.42 -6.22 -0.32 1.53e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs2084637 1.000 rs2100246 chr11:122406638 G/C cg21585512 chr11:122030076 LOC399959 -0.4 -7.29 -0.37 2.4e-12 Stroke; CRC cis rs11148252 0.553 rs9536219 chr13:53227301 C/T cg20354231 chr13:53171401 NA -0.41 -6.48 -0.34 3.43e-10 Lewy body disease; CRC cis rs9814567 0.806 rs4519744 chr3:134321523 T/C cg06109529 chr3:134205091 CEP63;ANAPC13 -0.68 -10.11 -0.49 4.15e-21 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC trans rs2303319 0.504 rs12473497 chr2:162433766 T/C cg12500891 chr11:57225987 NA -0.67 -5.98 -0.31 5.67e-9 Cognitive function; CRC cis rs7666738 0.822 rs979946 chr4:98921235 C/A cg05340658 chr4:99064831 C4orf37 0.6 9.26 0.45 2.81e-18 Colonoscopy-negative controls vs population controls; CRC cis rs2898681 0.519 rs6554057 chr4:53730147 A/T cg00338735 chr4:53728038 RASL11B 0.46 6.17 0.32 1.95e-9 Optic nerve measurement (cup area); CRC cis rs2180341 0.920 rs9398836 chr6:127576497 T/G cg24812749 chr6:127587940 RNF146 0.92 13.34 0.59 9.16e-33 Breast cancer; CRC cis rs514406 0.861 rs1749907 chr1:53259658 C/T cg25767906 chr1:53392781 SCP2 0.47 7.48 0.38 6.61e-13 Monocyte count; CRC cis rs9894429 1.000 rs35435780 chr17:79579602 G/T cg21028142 chr17:79581711 NPLOC4 0.39 8.62 0.43 2.89e-16 Eye color traits; CRC cis rs11229555 0.645 rs12801475 chr11:58189034 C/T cg15696309 chr11:58395628 NA -0.82 -10.31 -0.49 8.59e-22 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; CRC cis rs2535633 0.594 rs2581789 chr3:53096230 C/T cg11645453 chr3:52864694 ITIH4 -0.38 -6.84 -0.35 3.95e-11 Body mass index; CRC cis rs892961 1.000 rs1075457 chr17:75400737 A/G cg05865280 chr17:75406074 SEPT9 -0.62 -14.1 -0.61 1.24e-35 Airflow obstruction; CRC cis rs28386778 0.897 rs8067102 chr17:61848779 C/G cg25654072 chr17:61904446 PSMC5;FTSJ3 0.73 11.3 0.53 2.96e-25 Prudent dietary pattern; CRC cis rs9584850 0.834 rs3803253 chr13:99117149 G/A cg20487152 chr13:99095054 FARP1 0.43 6.28 0.33 1.1e-9 Neuroticism; CRC cis rs477895 0.653 rs3824854 chr11:63885305 C/T cg04317338 chr11:64019027 PLCB3 0.61 7.44 0.38 8.98e-13 Mean platelet volume; CRC cis rs4654899 0.743 rs17409373 chr1:21188871 C/A cg02927042 chr1:21476669 EIF4G3 -0.49 -7.83 -0.4 6.62e-14 Superior frontal gyrus grey matter volume; CRC trans rs10242455 0.702 rs59240302 chr7:99072991 C/G cg09045935 chr12:6379348 NA 1.14 8.88 0.44 4.43e-17 Blood metabolite levels; CRC cis rs7618915 0.571 rs17264436 chr3:52610651 T/A cg08222913 chr3:52553049 STAB1 -0.34 -6.27 -0.33 1.14e-9 Bipolar disorder; CRC cis rs7662987 0.517 rs2602880 chr4:100040653 C/T cg13256891 chr4:100009986 ADH5 0.63 8.54 0.43 4.99e-16 Smoking initiation; CRC cis rs12134245 0.874 rs35115044 chr1:92021650 A/G cg25838465 chr1:92012736 NA -0.57 -9.65 -0.47 1.46e-19 Breast cancer; CRC cis rs7772486 0.625 rs9390355 chr6:146112942 C/T cg13319975 chr6:146136371 FBXO30 0.46 6.91 0.36 2.53e-11 Lobe attachment (rater-scored or self-reported); CRC cis rs853679 0.517 rs35193936 chr6:28076270 A/G cg12172441 chr6:28176163 NA 0.62 7.33 0.37 1.76e-12 Depression; CRC trans rs9291683 0.632 rs13137074 chr4:10042842 C/T cg26043149 chr18:55253948 FECH 0.53 8.17 0.41 6.72e-15 Bone mineral density; CRC cis rs8141529 0.753 rs5752813 chr22:29226570 T/G cg02153584 chr22:29168773 CCDC117 0.5 7.52 0.38 5.15e-13 Lymphocyte counts; CRC cis rs6502050 0.835 rs7209474 chr17:80136418 C/T cg02741985 chr17:80059408 CCDC57 0.43 7.11 0.36 7.49e-12 Life satisfaction; CRC cis rs9926296 0.682 rs467357 chr16:89717397 A/G cg01097406 chr16:89675127 NA 0.53 9.64 0.47 1.53e-19 Vitiligo; CRC cis rs75920871 0.528 rs1241655 chr11:116837808 G/T cg01368799 chr11:117014884 PAFAH1B2 -0.4 -5.71 -0.3 2.53e-8 Subjective well-being; CRC cis rs28830936 1.000 rs2004162 chr15:41965542 A/G cg17847044 chr15:42102381 MAPKBP1 -0.28 -6.16 -0.32 2.13e-9 Diastolic blood pressure; CRC cis rs11098499 0.909 rs9994810 chr4:120381590 A/G cg24375607 chr4:120327624 NA 0.5 7.73 0.39 1.3e-13 Corneal astigmatism; CRC cis rs2160860 0.745 rs35995308 chr8:39800217 T/C cg11363097 chr8:39792086 IDO2 -0.45 -7.65 -0.39 2.28e-13 Blood metabolite levels; CRC cis rs7618915 0.547 rs34610142 chr3:52708429 G/A cg15147215 chr3:52552868 STAB1 -0.62 -10.31 -0.49 8.76e-22 Bipolar disorder; CRC trans rs7618501 0.633 rs6792892 chr3:49995518 T/C cg21659725 chr3:3221576 CRBN 0.6 9.45 0.46 6.65e-19 Intelligence (multi-trait analysis); CRC cis rs932287 0.505 rs2742536 chr11:8909816 G/C cg21881798 chr11:8931708 C11orf17;ST5 -0.72 -12.51 -0.57 1.24e-29 Colonoscopy-negative controls vs population controls; CRC cis rs3096299 0.658 rs3934737 chr16:89560209 G/A cg02187348 chr16:89574699 SPG7 0.4 5.87 0.31 1.06e-8 Multiple myeloma (IgH translocation); CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg12075659 chr20:19738521 NA -0.5 -6.47 -0.34 3.46e-10 Diisocyanate-induced asthma; CRC cis rs1799949 0.965 rs35521261 chr17:41313612 A/G cg05368731 chr17:41323189 NBR1 0.69 10.53 0.5 1.6e-22 Menopause (age at onset); CRC cis rs7020830 0.825 rs66684257 chr9:37199087 G/T cg14294708 chr9:37120828 ZCCHC7 1.05 19.85 0.74 3.26e-58 Schizophrenia; CRC cis rs13108904 0.901 rs12641735 chr4:1304434 G/C cg02018176 chr4:1364513 KIAA1530 0.39 6.4 0.33 5.28e-10 Obesity-related traits; CRC cis rs1552244 0.688 rs7645137 chr3:10020549 A/AT cg18598329 chr3:10140678 FANCD2;C3orf24 -0.81 -10.56 -0.5 1.19e-22 Alzheimer's disease; CRC cis rs7615952 0.641 rs6438951 chr3:125696999 A/G cg04553112 chr3:125709451 NA -0.49 -5.75 -0.3 2.04e-8 Blood pressure (smoking interaction); CRC cis rs11098499 0.954 rs28429722 chr4:120300093 G/A cg09307838 chr4:120376055 NA 0.71 10.93 0.52 6.41e-24 Corneal astigmatism; CRC cis rs9527 0.571 rs4917985 chr10:104624072 C/T cg04362960 chr10:104952993 NT5C2 0.56 7.77 0.39 9.91e-14 Arsenic metabolism; CRC cis rs4731207 0.596 rs2402757 chr7:124611713 A/G cg23710748 chr7:124431027 NA -0.39 -6.25 -0.33 1.29e-9 Cutaneous malignant melanoma; CRC cis rs6933660 0.745 rs9322320 chr6:151751908 C/G cg14262678 chr6:151773367 RMND1;C6orf211 0.54 8.93 0.44 3.08e-17 Menarche (age at onset); CRC cis rs13191362 0.935 rs34063386 chr6:163041271 T/C cg06582575 chr6:163149167 PACRG;PARK2 0.91 11.16 0.52 9.55e-25 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs834811 0.602 rs834813 chr7:135886783 T/A cg01726295 chr7:135938950 NA 0.41 7.16 0.37 5.28e-12 Post-traumatic stress disorder; CRC cis rs10071761 0.513 rs62359405 chr5:40380858 A/C cg09067459 chr5:40385259 NA -0.51 -6.91 -0.36 2.46e-11 Selective IgA deficiency; CRC cis rs736408 0.609 rs2268025 chr3:52795224 A/T cg11645453 chr3:52864694 ITIH4 0.37 6.33 0.33 7.89e-10 Bipolar disorder; CRC cis rs2249694 1.000 rs4512750 chr10:135358664 A/G cg20169779 chr10:135381914 SYCE1 0.61 9.93 0.48 1.67e-20 Obesity-related traits; CRC cis rs2204008 0.748 rs8186658 chr12:38301461 A/C cg13010199 chr12:38710504 ALG10B 0.47 6.63 0.34 1.37e-10 Bladder cancer; CRC cis rs9611565 0.512 rs964898 chr22:42142306 C/T cg03806693 chr22:41940476 POLR3H -1.06 -13.2 -0.59 3.3e-32 Vitiligo; CRC trans rs1814175 0.615 rs10839378 chr11:49806943 C/T cg11707556 chr5:10655725 ANKRD33B -0.5 -9.37 -0.46 1.22e-18 Height; CRC cis rs2842992 0.672 rs7738253 chr6:160193917 G/T cg16489826 chr6:160211363 TCP1;MRPL18 0.51 6.38 0.33 6.03e-10 Age-related macular degeneration (geographic atrophy); CRC cis rs9341808 0.667 rs12209624 chr6:80919133 G/A cg08355045 chr6:80787529 NA 0.34 5.83 0.31 1.3e-8 Sitting height ratio; CRC cis rs6582630 0.638 rs11182428 chr12:38526387 T/C cg26384229 chr12:38710491 ALG10B -0.54 -7.8 -0.39 8.34e-14 Drug-induced liver injury (flucloxacillin); CRC cis rs9916302 0.851 rs11868029 chr17:37650304 A/G cg15445000 chr17:37608096 MED1 0.41 8.81 0.44 7.25e-17 Glomerular filtration rate (creatinine); CRC cis rs9522267 0.535 rs9522301 chr13:112236726 A/T cg26182253 chr13:112236782 NA 0.32 6.36 0.33 6.93e-10 Hepatitis; CRC cis rs6952808 1.000 rs6957894 chr7:1887362 G/A cg00106254 chr7:1943704 MAD1L1 -0.4 -5.97 -0.31 6.09e-9 Bipolar disorder and schizophrenia; CRC cis rs3091242 0.967 rs3093614 chr1:25677844 T/A cg23205692 chr1:25664452 TMEM50A -0.39 -5.67 -0.3 3.14e-8 Erythrocyte sedimentation rate; CRC cis rs752010 0.714 rs10789403 chr1:42085869 G/A cg06885757 chr1:42089581 HIVEP3 0.49 8.92 0.44 3.21e-17 Lupus nephritis in systemic lupus erythematosus; CRC cis rs35740288 0.545 rs11637283 chr15:86316103 C/T cg20737812 chr15:86336631 KLHL25 -0.48 -7.15 -0.37 5.64e-12 Eosinophil percentage of white cells;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes; CRC trans rs8073060 0.586 rs225291 chr17:33927126 A/G cg19694781 chr19:47549865 TMEM160 -0.84 -12.04 -0.55 6.38e-28 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; CRC cis rs12142240 0.698 rs41293273 chr1:46806393 T/C cg00530320 chr1:46809349 NSUN4 0.57 7.8 0.39 8.39e-14 Menopause (age at onset); CRC cis rs7666738 0.753 rs10033138 chr4:98981922 A/C cg05340658 chr4:99064831 C4orf37 0.6 9.41 0.46 8.57e-19 Colonoscopy-negative controls vs population controls; CRC cis rs2976388 1.000 rs2920292 chr8:143765699 A/G cg22687807 chr8:143858763 LYNX1 -0.38 -6.67 -0.35 1.1e-10 Urinary tract infection frequency; CRC cis rs2522056 1.000 rs2405528 chr5:131794298 G/A cg24060327 chr5:131705240 SLC22A5 0.4 5.73 0.3 2.29e-8 Lymphocyte counts;Fibrinogen; CRC cis rs9858542 0.537 rs67882627 chr3:49380441 A/T cg00383909 chr3:49044727 WDR6 0.72 7.36 0.38 1.52e-12 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs2204008 0.777 rs6582664 chr12:37947022 A/G cg13010199 chr12:38710504 ALG10B -0.48 -7.15 -0.37 5.71e-12 Bladder cancer; CRC cis rs6951245 1.000 rs76214082 chr7:1102097 T/A cg04025307 chr7:1156635 C7orf50 0.64 6.81 0.35 4.53e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs11030122 0.702 rs17081 chr11:3987830 A/G cg18678763 chr11:4115507 RRM1 0.51 8.45 0.42 9.63e-16 Mean platelet volume;Platelet distribution width; CRC cis rs2456568 0.835 rs8181533 chr11:93638614 C/T cg26875233 chr11:93583750 C11orf90 -0.33 -6.36 -0.33 6.88e-10 Response to serotonin reuptake inhibitors in major depressive disorder; CRC cis rs4423214 0.879 rs1792283 chr11:71135136 T/C cg05163923 chr11:71159392 DHCR7 -0.63 -7.74 -0.39 1.2e-13 Vitamin D levels; CRC cis rs1008375 0.932 rs6841784 chr4:17626418 G/A cg16339924 chr4:17578868 LAP3 0.53 6.65 0.34 1.24e-10 Parasitemia in Tripanosoma cruzi seropositivity; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg18656860 chr13:50018171 SETDB2;CAB39L 0.35 5.99 0.31 5.58e-9 Liver disease severity in Alagille syndrome; CRC cis rs10752881 1.000 rs10797811 chr1:182984432 G/A ch.1.3577855R chr1:183094577 LAMC1 0.86 15.22 0.64 5.91e-40 Colorectal cancer; CRC cis rs1129187 0.934 rs9471974 chr6:42918984 T/A cg05552183 chr6:42928497 GNMT 0.61 9.73 0.47 8.13e-20 Alzheimer's disease in APOE e4+ carriers; CRC cis rs4713118 0.513 rs149958 chr6:28013617 A/C cg02683197 chr6:28174875 NA 0.62 8.4 0.42 1.32e-15 Parkinson's disease; CRC cis rs2677744 0.626 rs11854429 chr15:91489685 C/T cg23684204 chr15:91497937 RCCD1 -0.44 -6.66 -0.34 1.17e-10 Attention deficit hyperactivity disorder; CRC cis rs2836974 0.563 rs997147 chr21:40695325 A/G cg11890956 chr21:40555474 PSMG1 -0.85 -14.1 -0.61 1.22e-35 Cognitive function; CRC cis rs7772486 0.790 rs80050589 chr6:146230454 T/C cg23711669 chr6:146136114 FBXO30 -0.72 -12.75 -0.58 1.54e-30 Lobe attachment (rater-scored or self-reported); CRC cis rs6912958 0.712 rs9444525 chr6:88324142 T/C cg08069147 chr6:88032118 GJB7;C6orf162 -0.58 -8.64 -0.43 2.56e-16 Monocyte percentage of white cells; CRC cis rs853679 0.585 rs201001 chr6:27808899 T/C cg20933634 chr6:27740509 NA 0.58 6.81 0.35 4.67e-11 Depression; CRC cis rs75804782 0.641 rs1030786 chr2:239361150 A/G cg18131467 chr2:239335373 ASB1 -0.68 -5.88 -0.31 1.01e-8 Morning vs. evening chronotype;Chronotype; CRC cis rs6952808 0.929 rs11768206 chr7:1932151 T/G cg20295408 chr7:1910781 MAD1L1 -0.44 -6.2 -0.32 1.65e-9 Bipolar disorder and schizophrenia; CRC cis rs6952808 0.929 rs11768206 chr7:1932151 T/G cg00106254 chr7:1943704 MAD1L1 -0.51 -7.56 -0.38 3.92e-13 Bipolar disorder and schizophrenia; CRC cis rs2882667 0.964 rs11739351 chr5:138311742 A/G cg09476006 chr5:138032270 NA 0.48 8.1 0.41 1.11e-14 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs4728302 0.594 rs4596578 chr7:133697429 T/C cg03336402 chr7:133662267 EXOC4 -0.53 -8.3 -0.42 2.76e-15 Intelligence;Intelligence (multi-trait analysis); CRC cis rs9611565 0.729 rs73176686 chr22:41782119 C/T cg06481639 chr22:41940642 POLR3H -0.51 -5.73 -0.3 2.22e-8 Vitiligo; CRC cis rs2346160 1.000 rs4709159 chr6:167664918 C/T cg04673565 chr6:167680447 NA -0.38 -6.44 -0.33 4.33e-10 Parental extreme longevity (95 years and older); CRC cis rs11864453 0.826 rs2074627 chr16:72136769 C/T cg01557791 chr16:72042693 DHODH -0.47 -6.59 -0.34 1.76e-10 Fibrinogen levels; CRC trans rs7027930 0.524 rs16921144 chr9:614485 C/G cg27061366 chr19:13044373 FARSA 0.5 6.15 0.32 2.24e-9 Pulmonary function decline; CRC cis rs752010 0.619 rs6703992 chr1:42115888 G/A cg06885757 chr1:42089581 HIVEP3 0.44 7.06 0.36 9.65e-12 Lupus nephritis in systemic lupus erythematosus; CRC cis rs7666738 0.716 rs6814353 chr4:99074202 A/G cg17366294 chr4:99064904 C4orf37 0.4 6.57 0.34 1.94e-10 Colonoscopy-negative controls vs population controls; CRC cis rs9300255 0.602 rs1727313 chr12:123640853 C/G cg00376283 chr12:123451042 ABCB9 0.61 7.53 0.38 4.96e-13 Neutrophil percentage of white cells; CRC cis rs477692 1.000 rs580745 chr10:131414401 G/A cg05714579 chr10:131428358 MGMT 0.53 7.81 0.4 7.92e-14 Response to temozolomide; CRC cis rs597539 0.652 rs478647 chr11:68700424 C/T cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.88 15.19 0.64 7.26e-40 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs780096 0.546 rs1528533 chr2:27595756 G/C cg24768116 chr2:27665128 KRTCAP3 -0.36 -8.11 -0.41 1.01e-14 Total body bone mineral density; CRC cis rs870825 0.616 rs36022027 chr4:185639192 C/T cg04058563 chr4:185651563 MLF1IP 0.73 9.54 0.47 3.37e-19 Blood protein levels; CRC cis rs7412746 0.611 rs11204726 chr1:150743492 T/C cg17724175 chr1:150552817 MCL1 0.48 7.08 0.36 8.66e-12 Melanoma; CRC cis rs9487051 0.872 rs9487034 chr6:109605899 A/G cg12927641 chr6:109611667 NA -0.37 -6.64 -0.34 1.27e-10 Reticulocyte fraction of red cells; CRC cis rs9399137 0.529 rs7739722 chr6:135282225 T/C cg22676075 chr6:135203613 NA 0.6 8.91 0.44 3.6e-17 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; CRC cis rs2880765 0.545 rs11631739 chr15:86012578 T/C cg10818794 chr15:86012489 AKAP13 -0.51 -7.96 -0.4 2.72e-14 Coronary artery disease; CRC cis rs4964805 1.000 rs73192052 chr12:104190854 C/T cg02344784 chr12:104178138 NT5DC3 0.51 7.17 0.37 4.91e-12 Attention deficit hyperactivity disorder; CRC cis rs9549260 0.709 rs2721072 chr13:41144919 G/A cg21288729 chr13:41239152 FOXO1 0.42 6.39 0.33 5.63e-10 Red blood cell count; CRC cis rs7236492 0.748 rs78531995 chr18:77198370 C/T cg15644404 chr18:77186268 NFATC1 -0.57 -5.87 -0.31 1.07e-8 Inflammatory bowel disease;Crohn's disease; CRC cis rs9549328 0.565 rs36145949 chr13:113616608 T/C cg17524180 chr13:113633600 MCF2L 0.52 9.39 0.46 1e-18 Systolic blood pressure; CRC cis rs11785400 1.000 rs11785400 chr8:143730456 C/T cg10596483 chr8:143751796 JRK 0.5 7.01 0.36 1.37e-11 Schizophrenia; CRC cis rs1348850 0.914 rs11893448 chr2:178280013 T/C cg02961200 chr2:178257176 LOC100130691;AGPS 0.62 9.25 0.45 2.87e-18 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs61008539 0.893 rs4719460 chr7:859610 C/T cg05535760 chr7:792225 HEATR2 0.44 5.7 0.3 2.67e-8 Perceived unattractiveness to mosquitoes; CRC cis rs6424115 0.708 rs12748109 chr1:24181177 C/T cg15997130 chr1:24165203 NA -0.62 -8.09 -0.41 1.19e-14 Immature fraction of reticulocytes; CRC cis rs4555082 0.874 rs2816612 chr14:105723103 C/T cg18132624 chr14:105716052 BTBD6;BRF1 -0.46 -7.34 -0.38 1.67e-12 Mean platelet volume;Platelet distribution width; CRC cis rs10486722 0.564 rs7811316 chr7:41788530 A/G cg22138096 chr7:41772439 LOC285954 0.43 5.62 0.3 3.98e-8 Pit-and-Fissure caries; CRC cis rs6484504 0.576 rs208091 chr11:31190099 G/C cg14844989 chr11:31128820 NA -0.34 -5.93 -0.31 7.82e-9 Red blood cell count; CRC cis rs2243480 0.901 rs35823062 chr7:65965821 A/G cg12463550 chr7:65579703 CRCP 0.67 6.1 0.32 2.98e-9 Diabetic kidney disease; CRC cis rs7845219 0.544 rs10956930 chr8:95919786 C/G cg16049864 chr8:95962084 TP53INP1 -0.44 -6.77 -0.35 6.08e-11 Type 2 diabetes; CRC trans rs13086611 1 rs13086611 chr3:49385417 A/T cg21665057 chr3:196295764 WDR53;FBXO45 -0.53 -7.09 -0.36 8.21e-12 Educational attainment; CRC cis rs4589502 0.800 rs12595796 chr15:67202599 A/G cg09911534 chr15:67153556 NA 0.46 5.99 0.31 5.46e-9 Lung cancer (smoking interaction); CRC cis rs2882667 0.898 rs3828600 chr5:138386859 G/T cg09476006 chr5:138032270 NA 0.44 7.15 0.37 5.68e-12 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs7191439 0.858 rs7205626 chr16:88780472 T/C cg27087555 chr16:88793112 FAM38A -1.36 -13.12 -0.59 6.54e-32 Plateletcrit; CRC cis rs4237845 0.773 rs6650218 chr12:58289078 T/A cg02175503 chr12:58329896 NA 0.59 8.32 0.42 2.29e-15 Intelligence (multi-trait analysis); CRC cis rs9914988 0.887 rs4795463 chr17:27146389 G/C cg16670446 chr17:27188758 MIR451;MIR144 0.53 8.4 0.42 1.32e-15 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs6456156 0.711 rs1855025 chr6:167537594 A/G cg07741184 chr6:167504864 NA -0.32 -5.65 -0.3 3.55e-8 Primary biliary cholangitis; CRC cis rs514406 0.825 rs487453 chr1:53271225 T/C cg08859206 chr1:53392774 SCP2 0.44 7.11 0.37 7.13e-12 Monocyte count; CRC cis rs35883536 1.000 rs4243810 chr1:101139914 T/C cg14515779 chr1:101123966 NA -0.39 -7.56 -0.38 4.11e-13 Monocyte count; CRC cis rs12142240 0.698 rs6683192 chr1:46830257 C/T cg00530320 chr1:46809349 NSUN4 0.59 8.11 0.41 1.02e-14 Menopause (age at onset); CRC cis rs10504229 0.683 rs7817188 chr8:58129549 C/T cg05313129 chr8:58192883 C8orf71 -0.43 -6.11 -0.32 2.74e-9 Developmental language disorder (linguistic errors); CRC cis rs6764363 0.587 rs455635 chr3:285316 G/T cg02057681 chr3:285234 CHL1 -0.43 -7.23 -0.37 3.44e-12 Sudden cardiac arrest; CRC cis rs10791323 0.559 rs10750549 chr11:133730820 A/G cg15485101 chr11:133734466 NA 0.47 7.91 0.4 3.89e-14 Childhood ear infection; CRC trans rs2303319 0.504 rs56026147 chr2:162614089 T/C cg10272801 chr16:14013773 ERCC4 -0.68 -6.07 -0.32 3.49e-9 Cognitive function; CRC cis rs11785400 1.000 rs4266629 chr8:143736635 A/G cg24634471 chr8:143751801 JRK 0.52 7.35 0.38 1.63e-12 Schizophrenia; CRC cis rs12620999 0.941 rs58678188 chr2:237971036 C/A cg23555395 chr2:238036564 NA 0.51 7.87 0.4 5.15e-14 Systemic lupus erythematosus; CRC trans rs9291683 0.605 rs73224439 chr4:10331818 C/A cg26043149 chr18:55253948 FECH -0.53 -7.79 -0.39 8.74e-14 Bone mineral density; CRC trans rs11098499 0.754 rs1511025 chr4:120240238 T/C cg25214090 chr10:38739885 LOC399744 0.53 8.45 0.42 9.68e-16 Corneal astigmatism; CRC cis rs747650 0.892 rs1976142 chr11:47225694 T/C cg03339077 chr11:47165057 C11orf49 0.46 6.51 0.34 2.85e-10 Acne (severe); CRC trans rs1814175 0.645 rs1851853 chr11:49953434 C/T cg11707556 chr5:10655725 ANKRD33B -0.52 -10.05 -0.48 6.61e-21 Height; CRC cis rs4664304 1.000 rs4664304 chr2:160794008 A/G cg03641300 chr2:160917029 PLA2R1 -0.46 -6.6 -0.34 1.67e-10 Crohn's disease;Inflammatory bowel disease; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg01194336 chr12:66627997 IRAK3 0.37 6.16 0.32 2.12e-9 Liver disease severity in Alagille syndrome; CRC cis rs853679 0.517 rs6941992 chr6:28106141 T/C cg15845792 chr6:28175446 NA 1.01 13.54 0.6 1.59e-33 Depression; CRC cis rs9527 0.590 rs2281877 chr10:104866062 C/T cg15744005 chr10:104629667 AS3MT -0.31 -6.06 -0.32 3.66e-9 Arsenic metabolism; CRC cis rs7781266 0.739 rs1149551 chr7:133074763 C/T cg03336402 chr7:133662267 EXOC4 -0.49 -5.92 -0.31 8.06e-9 Educational attainment (college completion); CRC trans rs7647973 0.626 rs4855846 chr3:49683526 G/A cg21665057 chr3:196295764 WDR53;FBXO45 -0.68 -7.46 -0.38 7.88e-13 Menarche (age at onset); CRC cis rs8060686 0.858 rs7191129 chr16:67801391 A/G cg07125278 chr16:67683757 RLTPR -0.49 -6.46 -0.34 3.84e-10 HDL cholesterol;Metabolic syndrome; CRC trans rs12478296 1.000 rs12469535 chr2:243044147 G/A cg18288967 chr1:45987694 PRDX1 0.7 7.87 0.4 5.34e-14 Obesity-related traits; CRC cis rs4862307 0.836 rs6829678 chr4:185001631 C/T cg06737308 chr4:185021514 ENPP6 -0.46 -7.39 -0.38 1.24e-12 Serum dimethylarginine levels (asymmetric/symetric ratio); CRC cis rs6942756 0.955 rs9641849 chr7:128899238 C/T cg02491457 chr7:128862824 NA -0.76 -10.45 -0.5 3e-22 White matter hyperintensity burden; CRC cis rs6582630 0.638 rs12831496 chr12:38552604 G/A cg13010199 chr12:38710504 ALG10B -0.42 -6.06 -0.32 3.71e-9 Drug-induced liver injury (flucloxacillin); CRC cis rs6582630 0.519 rs4002438 chr12:38484880 C/T cg13010199 chr12:38710504 ALG10B 0.49 6.49 0.34 3.13e-10 Drug-induced liver injury (flucloxacillin); CRC cis rs10193935 0.818 rs10221927 chr2:42546680 A/C cg27598129 chr2:42591480 NA -0.66 -7.72 -0.39 1.4e-13 Colonoscopy-negative controls vs population controls; CRC cis rs6502050 0.799 rs4132775 chr17:80155412 C/T cg09264619 chr17:80180166 NA -0.35 -5.95 -0.31 6.9e-9 Life satisfaction; CRC cis rs1878931 0.668 rs11643983 chr16:3438865 G/A cg26668626 chr16:3451006 ZNF174;ZNF434 0.96 17.03 0.68 4.53e-47 Body mass index (adult); CRC trans rs10983614 1.000 rs7867776 chr9:120072627 A/G cg07927484 chr5:153826296 SAP30L 0.45 6.0 0.31 5.24e-9 Survival in pancreatic cancer; CRC cis rs9322193 0.962 rs4869966 chr6:150084850 A/G cg00933542 chr6:150070202 PCMT1 0.28 5.69 0.3 2.75e-8 Lung cancer; CRC cis rs6460942 1.000 rs2053382 chr7:12400587 A/G cg20607287 chr7:12443886 VWDE -0.67 -6.75 -0.35 6.87e-11 Coronary artery disease; CRC cis rs6582630 0.555 rs7294313 chr12:38323603 G/A cg13010199 chr12:38710504 ALG10B -0.41 -5.74 -0.3 2.21e-8 Drug-induced liver injury (flucloxacillin); CRC cis rs28374715 0.662 rs522063 chr15:41476209 A/G cg18705301 chr15:41695430 NDUFAF1 0.85 13.31 0.59 1.28e-32 Ulcerative colitis; CRC cis rs9911578 0.935 rs9893351 chr17:57023326 G/A cg05425664 chr17:57184151 TRIM37 -0.45 -6.97 -0.36 1.7e-11 Intelligence (multi-trait analysis); CRC cis rs568617 1.000 rs694994 chr11:65653309 A/G cg19792802 chr11:65647270 CTSW 0.46 7.18 0.37 4.64e-12 Crohn's disease; CRC cis rs514406 0.644 rs928451 chr1:53195800 A/G cg24675658 chr1:53192096 ZYG11B 0.68 10.55 0.5 1.36e-22 Monocyte count; CRC cis rs9303401 1.000 rs9904677 chr17:56873025 A/G cg10487724 chr17:56770010 TEX14;RAD51C 0.56 8.2 0.41 5.52e-15 Cognitive test performance; CRC cis rs12477438 0.871 rs62156364 chr2:99695097 A/G cg26064155 chr2:99771622 LIPT1;TSGA10 -0.7 -8.68 -0.43 1.89e-16 Chronic sinus infection; CRC cis rs2204008 0.837 rs11180482 chr12:38235950 G/A cg26384229 chr12:38710491 ALG10B 0.68 9.08 0.45 9.92e-18 Bladder cancer; CRC cis rs921968 0.612 rs4674323 chr2:219517088 T/C cg02176678 chr2:219576539 TTLL4 0.5 7.96 0.4 2.79e-14 Mean corpuscular hemoglobin concentration; CRC cis rs6502050 0.736 rs11658040 chr17:80059891 C/T cg02741985 chr17:80059408 CCDC57 -0.45 -7.21 -0.37 3.89e-12 Life satisfaction; CRC cis rs7762018 0.505 rs79938197 chr6:170059932 A/T cg19338460 chr6:170058176 WDR27 -1.26 -9.1 -0.45 9e-18 Thiazide-induced adverse metabolic effects in hypertensive patients; CRC trans rs2908835 0.521 rs1950111 chr12:11608877 C/T cg03979024 chr10:419189 DIP2C -0.39 -6.1 -0.32 3.05e-9 Information processing speed; CRC cis rs6896969 0.560 rs7725523 chr5:40372223 A/G cg09067459 chr5:40385259 NA 0.45 6.96 0.36 1.87e-11 Multiple sclerosis; CRC cis rs6456156 0.755 rs4710182 chr6:167514061 G/A cg07741184 chr6:167504864 NA 0.49 8.47 0.42 8.25e-16 Primary biliary cholangitis; CRC cis rs1448094 0.556 rs2061686 chr12:86170951 C/T cg18827107 chr12:86230957 RASSF9 0.38 6.08 0.32 3.42e-9 Major depressive disorder; CRC cis rs9322193 0.923 rs4869812 chr6:149990583 A/G cg07701084 chr6:150067640 NUP43 0.56 8.23 0.41 4.29e-15 Lung cancer; CRC cis rs10256972 0.552 rs2960837 chr7:1203957 A/G cg26608667 chr7:1196370 ZFAND2A 0.42 6.85 0.35 3.73e-11 Longevity;Endometriosis; CRC cis rs2274273 0.588 rs7154831 chr14:55823965 A/C cg10130446 chr14:55658398 DLGAP5 -0.43 -6.02 -0.32 4.58e-9 Protein biomarker; CRC cis rs6748734 1.000 rs6748734 chr2:241837452 A/G cg16358738 chr2:241808595 AGXT -0.41 -6.12 -0.32 2.73e-9 Urinary metabolites; CRC cis rs2836974 0.899 rs35774464 chr21:40580169 G/A cg11644478 chr21:40555479 PSMG1 0.72 10.42 0.5 3.71e-22 Cognitive function; CRC cis rs13118159 0.509 rs4974554 chr4:1356967 A/C cg02018176 chr4:1364513 KIAA1530 0.72 12.46 0.57 1.95e-29 Longevity; CRC cis rs8105895 0.935 rs2043317 chr19:22251096 T/C cg02657401 chr19:22469223 NA -0.34 -5.65 -0.3 3.56e-8 Body mass index (change over time); CRC cis rs73200209 0.744 rs11616043 chr12:116559922 T/C cg01776926 chr12:116560359 MED13L -0.61 -7.16 -0.37 5.26e-12 Total body bone mineral density; CRC cis rs2204008 0.640 rs2320744 chr12:38162389 A/G cg13010199 chr12:38710504 ALG10B 0.44 5.62 0.3 3.99e-8 Bladder cancer; CRC cis rs651907 0.557 rs11720745 chr3:101441690 G/A cg12386194 chr3:101231763 SENP7 0.5 7.37 0.38 1.42e-12 Colorectal cancer; CRC cis rs796364 1.000 rs11694369 chr2:200741720 G/A cg12253985 chr2:200820533 C2orf60;C2orf47 -0.65 -6.38 -0.33 5.89e-10 Schizophrenia; CRC cis rs863345 0.625 rs4575081 chr1:158504837 C/A cg12129480 chr1:158549410 OR10X1 -0.3 -6.27 -0.33 1.12e-9 Pneumococcal bacteremia; CRC cis rs7605827 0.930 rs7596951 chr2:15513473 G/C cg19274914 chr2:15703543 NA 0.38 5.8 0.3 1.59e-8 Educational attainment (years of education); CRC trans rs1814175 0.817 rs4881627 chr11:49953955 C/A cg15704280 chr7:45808275 SEPT13 -0.97 -18.82 -0.72 3.98e-54 Height; CRC cis rs3820068 0.581 rs78175477 chr1:15948091 C/G cg13390004 chr1:15929781 NA 0.5 7.11 0.37 7.21e-12 Systolic blood pressure; CRC cis rs10504229 0.683 rs2318147 chr8:58114931 C/T cg02725872 chr8:58115012 NA -0.55 -7.94 -0.4 3.16e-14 Developmental language disorder (linguistic errors); CRC cis rs2072499 0.554 rs1052067 chr1:156206121 C/T cg25208724 chr1:156163844 SLC25A44 0.74 10.37 0.5 5.52e-22 Testicular germ cell tumor; CRC cis rs490234 0.702 rs4838275 chr9:128352785 C/T cg14078157 chr9:128172775 NA -0.4 -6.58 -0.34 1.82e-10 Mean arterial pressure; CRC cis rs883565 0.569 rs2949565 chr3:39163425 G/A cg01426195 chr3:39028469 NA 0.42 6.97 0.36 1.69e-11 Handedness; CRC cis rs7666738 0.791 rs2903151 chr4:99027218 T/C cg05340658 chr4:99064831 C4orf37 0.61 9.42 0.46 8.23e-19 Colonoscopy-negative controls vs population controls; CRC cis rs2108622 0.727 rs8102532 chr19:15980060 G/A cg13772218 chr19:15982569 NA 0.49 6.69 0.35 9.87e-11 Circulating phylloquinone levels;Vitamin E levels;Acenocoumarol maintenance dosage;Response to Vitamin E supplementation;Metabolite levels;Warfarin maintenance dose; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg14256136 chr10:74856824 P4HA1 0.45 6.75 0.35 6.83e-11 Intelligence (multi-trait analysis); CRC cis rs9906695 0.615 rs12453746 chr17:32635581 G/T cg12698626 chr17:32581466 CCL2 0.43 5.89 0.31 9.51e-9 Monocyte percentage of white cells; CRC cis rs35883536 1.000 rs11583008 chr1:101085094 A/G cg14515779 chr1:101123966 NA -0.45 -8.46 -0.42 9.07e-16 Monocyte count; CRC cis rs9322193 0.923 rs9322214 chr6:150025122 C/T cg13206674 chr6:150067644 NUP43 0.66 9.56 0.47 2.91e-19 Lung cancer; CRC cis rs9515201 0.859 rs9521732 chr13:111033821 G/T cg05272587 chr13:111038400 COL4A2 -0.42 -6.8 -0.35 4.85e-11 White matter hyperintensity burden; CRC cis rs2204008 0.869 rs34438288 chr12:38211582 G/T cg13010199 chr12:38710504 ALG10B 0.45 5.74 0.3 2.1e-8 Bladder cancer; CRC cis rs916888 0.821 rs199509 chr17:44858728 G/A cg01570182 chr17:44337453 NA -1.07 -12.8 -0.58 9.93e-31 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs9399137 0.507 rs12664898 chr6:135288663 T/C cg24558204 chr6:135376177 HBS1L 0.6 8.94 0.44 2.84e-17 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; CRC cis rs1801251 0.727 rs283482 chr2:233646920 A/T cg25237894 chr2:233734115 C2orf82 0.46 7.22 0.37 3.72e-12 Coronary artery disease; CRC cis rs11098499 1.000 rs35643470 chr4:120184948 T/C cg09307838 chr4:120376055 NA 0.62 9.56 0.47 2.9e-19 Corneal astigmatism; CRC cis rs12586317 0.547 rs76770287 chr14:35487210 C/A cg05294307 chr14:35346193 BAZ1A -0.7 -7.7 -0.39 1.65e-13 Psoriasis; CRC cis rs10426930 0.607 rs877287 chr19:5041989 G/A cg18473234 chr19:5097819 KDM4B 0.45 5.77 0.3 1.79e-8 Monocyte percentage of white cells; CRC cis rs72781680 0.664 rs2712076 chr2:23993366 T/C cg08917208 chr2:24149416 ATAD2B 0.56 6.41 0.33 4.92e-10 Lymphocyte counts; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg01016553 chr1:51810627 TTC39A 0.4 6.81 0.35 4.68e-11 Liver disease severity in Alagille syndrome; CRC cis rs9649213 0.593 rs6949718 chr7:97924483 G/A cg00277769 chr7:97922759 BAIAP2L1 -0.61 -10.69 -0.51 4.4e-23 Prostate cancer (SNP x SNP interaction); CRC cis rs2836974 0.865 rs7282624 chr21:40667040 C/T cg11644478 chr21:40555479 PSMG1 0.78 11.66 0.54 1.58e-26 Cognitive function; CRC cis rs9796 0.870 rs2927061 chr15:41302219 A/G cg18705301 chr15:41695430 NDUFAF1 -0.33 -5.67 -0.3 3.16e-8 Menopause (age at onset); CRC cis rs916888 0.773 rs199457 chr17:44795469 C/T cg01570182 chr17:44337453 NA 1.24 14.27 0.62 2.68e-36 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC trans rs6557786 0.636 rs17052934 chr8:24840319 A/C cg00425918 chr8:23563146 NKX2-6 -0.33 -6.25 -0.33 1.29e-9 Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 2 peripheral neuropathy); CRC cis rs11997175 0.574 rs9642707 chr8:33645789 C/G ch.8.33884649F chr8:33765107 NA 0.47 7.44 0.38 8.68e-13 Body mass index; CRC cis rs1003719 0.751 rs2835585 chr21:38460488 T/A cg10648535 chr21:38446584 PIGP;TTC3 0.51 7.21 0.37 3.77e-12 Eye color traits; CRC cis rs9287719 0.967 rs7587114 chr2:10739963 C/T cg00105475 chr2:10696890 NA 0.45 7.3 0.37 2.19e-12 Prostate cancer; CRC cis rs6502050 0.835 rs8077926 chr17:80117315 C/A cg22110888 chr17:80059540 CCDC57 0.4 6.48 0.34 3.37e-10 Life satisfaction; CRC cis rs561341 0.941 rs2428341 chr17:30317295 C/T cg00745463 chr17:30367425 LRRC37B -0.61 -7.83 -0.4 6.91e-14 Hip circumference adjusted for BMI; CRC cis rs4474465 0.920 rs10899535 chr11:78216237 G/A cg27205649 chr11:78285834 NARS2 0.46 5.74 0.3 2.11e-8 Alzheimer's disease (survival time); CRC cis rs7666738 0.962 rs2865950 chr4:99040061 T/C cg03676636 chr4:99064102 C4orf37 0.23 6.35 0.33 7.31e-10 Colonoscopy-negative controls vs population controls; CRC cis rs1153858 1.000 rs56669689 chr15:45637729 A/C cg10760299 chr15:45669010 GATM 0.5 7.99 0.4 2.37e-14 Homoarginine levels; CRC cis rs4665809 0.938 rs35844686 chr2:26304949 A/G cg25036284 chr2:26402008 FAM59B 0.54 6.41 0.33 5.04e-10 Gut microbiome composition (summer); CRC cis rs9322193 0.923 rs7753812 chr6:150011286 C/T cg00933542 chr6:150070202 PCMT1 0.28 5.65 0.3 3.5e-8 Lung cancer; CRC cis rs9318086 0.712 rs9318099 chr13:24442462 C/G cg25267304 chr13:24462978 PCOTH;MIPEP -0.62 -10.05 -0.48 6.58e-21 Myopia (pathological); CRC cis rs568617 1.000 rs687672 chr11:65649984 T/C cg19792802 chr11:65647270 CTSW -0.5 -7.55 -0.38 4.23e-13 Crohn's disease; CRC cis rs6940638 0.688 rs9348750 chr6:27057945 T/G cg12292205 chr6:26970375 C6orf41 -0.47 -6.5 -0.34 3e-10 Intelligence (multi-trait analysis); CRC cis rs540254 0.578 rs4656933 chr1:160782561 T/A cg20255094 chr1:160771763 LY9 0.48 6.4 0.33 5.44e-10 Blood protein levels; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg17176228 chr8:145159019 SHARPIN;MAF1 0.46 6.61 0.34 1.51e-10 Anxiety disorder; CRC cis rs2979489 0.945 rs11988541 chr8:30334273 G/A cg26383811 chr8:30366931 RBPMS -0.7 -9.84 -0.48 3.29e-20 Mean corpuscular hemoglobin;Plateletcrit;Neutrophil count;Granulocyte count;Sum basophil neutrophil counts;Mean corpuscular volume;Myeloid white cell count;Sum neutrophil eosinophil counts; CRC cis rs910316 0.783 rs11850751 chr14:75590113 A/T cg08847533 chr14:75593920 NEK9 0.93 17.42 0.69 1.32e-48 Height; CRC trans rs7395662 0.927 rs12793888 chr11:48488056 A/G cg21153622 chr11:89784906 NA -0.5 -8.01 -0.4 1.95e-14 HDL cholesterol; CRC cis rs12586317 0.534 rs2273157 chr14:35438836 A/G cg16230307 chr14:35515116 FAM177A1 0.7 9.02 0.45 1.55e-17 Psoriasis; CRC cis rs9479482 1.000 rs11754987 chr6:150351204 G/A cg25797454 chr6:150327115 RAET1K 0.38 6.38 0.33 5.86e-10 Alopecia areata; CRC cis rs1153858 1.000 rs9788780 chr15:45685487 T/A cg10760299 chr15:45669010 GATM 0.52 7.87 0.4 5.07e-14 Homoarginine levels; CRC cis rs9910055 0.529 rs228766 chr17:42186813 A/G cg13607699 chr17:42295918 UBTF -0.45 -5.81 -0.3 1.51e-8 Total body bone mineral density; CRC cis rs28386778 0.805 rs9911714 chr17:61828952 G/A cg23090583 chr17:61904693 PSMC5;FTSJ3 1.04 20.18 0.74 1.61e-59 Prudent dietary pattern; CRC cis rs116095464 0.614 rs10061564 chr5:271329 T/C cg22857025 chr5:266934 NA -1.24 -16.67 -0.68 1.18e-45 Breast cancer; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg24458652 chr1:231377103 C1orf131;GNPAT 0.46 6.51 0.34 2.8e-10 Response to antipsychotic treatment; CRC cis rs870825 0.616 rs61653735 chr4:185630025 G/A cg04058563 chr4:185651563 MLF1IP 0.72 9.1 0.45 8.81e-18 Blood protein levels; CRC trans rs2228479 0.850 rs17233455 chr16:89816407 A/G cg24644049 chr4:85504048 CDS1 0.9 7.46 0.38 7.69e-13 Skin colour saturation; CRC cis rs1577917 1.000 rs12213149 chr6:86668644 G/A cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.52 -6.53 -0.34 2.57e-10 Response to antipsychotic treatment; CRC trans rs875971 0.545 rs73148639 chr7:65855329 A/T cg02869306 chr7:64672164 INTS4L1 -0.42 -6.18 -0.32 1.89e-9 Aortic root size; CRC cis rs1005277 0.540 rs1814077 chr10:37992018 G/C cg25427524 chr10:38739819 LOC399744 -0.73 -12.58 -0.57 6.83e-30 Extrinsic epigenetic age acceleration; CRC cis rs2361718 0.603 rs12951255 chr17:78085597 A/G cg21238619 chr17:78079768 GAA -0.4 -7.64 -0.39 2.42e-13 Yeast infection; CRC cis rs4713118 0.513 rs149950 chr6:28033039 T/G cg12273811 chr6:28175739 NA 0.57 8.23 0.41 4.52e-15 Parkinson's disease; CRC cis rs1552244 1.000 rs58275763 chr3:10143274 C/T cg10729496 chr3:10149963 C3orf24 0.55 7.29 0.37 2.36e-12 Alzheimer's disease; CRC cis rs2243480 1.000 rs316317 chr7:65613637 G/T cg12463550 chr7:65579703 CRCP 0.74 6.66 0.34 1.14e-10 Diabetic kidney disease; CRC cis rs977987 0.806 rs7188231 chr16:75436561 T/C cg03315344 chr16:75512273 CHST6 0.52 8.79 0.44 8.7e-17 Dupuytren's disease; CRC cis rs10504229 0.679 rs12375285 chr8:58040084 G/A cg02725872 chr8:58115012 NA -0.41 -6.38 -0.33 6.05e-10 Developmental language disorder (linguistic errors); CRC cis rs11711311 0.955 rs34048496 chr3:113414121 C/T cg15478005 chr3:113465772 ATP6V1A;NAA50 0.47 6.33 0.33 7.9e-10 IgG glycosylation; CRC cis rs4819052 0.851 rs914218 chr21:46698445 G/C cg19498844 chr21:46707878 POFUT2;LOC642852 0.8 11.6 0.54 2.68e-26 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg13794888 chr15:75917792 SNUPN 0.43 6.06 0.32 3.72e-9 Response to antipsychotic treatment; CRC cis rs2839186 0.558 rs2968 chr21:47608580 C/T cg09417038 chr21:47716443 C21orf57 0.38 6.56 0.34 2.12e-10 Testicular germ cell tumor; CRC cis rs9916302 0.904 rs11655531 chr17:37697959 T/C cg15445000 chr17:37608096 MED1 0.42 9.22 0.45 3.56e-18 Glomerular filtration rate (creatinine); CRC cis rs6435862 0.500 rs12477063 chr2:215673664 C/T cg04004882 chr2:215674386 BARD1 -0.57 -9.02 -0.45 1.58e-17 Neuroblastoma (high-risk); CRC cis rs4819052 0.851 rs2838845 chr21:46670812 A/G cg19498844 chr21:46707878 POFUT2;LOC642852 0.73 10.79 0.51 1.91e-23 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs9733 0.596 rs6587518 chr1:150661787 T/C cg10589385 chr1:150898437 SETDB1 0.28 5.95 0.31 6.76e-9 Tonsillectomy; CRC cis rs7945718 0.621 rs11022464 chr11:12685477 T/C cg25843174 chr11:12811716 TEAD1 0.39 7.17 0.37 4.89e-12 Educational attainment (years of education); CRC cis rs4332037 0.539 rs55988458 chr7:2059761 G/A cg25834613 chr7:1915315 MAD1L1 -0.42 -5.93 -0.31 7.82e-9 Bipolar disorder; CRC cis rs9914988 0.943 rs2874253 chr17:27157863 A/T cg12682573 chr17:27188876 MIR451;MIR144 0.57 7.99 0.4 2.37e-14 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs72945132 0.882 rs11235967 chr11:70191691 T/C cg00319359 chr11:70116639 PPFIA1 0.65 7.24 0.37 3.24e-12 Coronary artery disease; CRC cis rs910316 1.000 rs175443 chr14:75601963 C/T cg11812906 chr14:75593930 NEK9 -0.56 -8.78 -0.44 9.43e-17 Height; CRC cis rs601339 1.000 rs7969523 chr12:123168636 T/G cg25190513 chr12:123201362 GPR109B -0.48 -5.94 -0.31 7.24e-9 Adiponectin levels; CRC cis rs7927592 0.763 rs10896340 chr11:68312645 A/G cg16797656 chr11:68205561 LRP5 -0.48 -8.87 -0.44 4.67e-17 Total body bone mineral density; CRC trans rs10242455 0.702 rs28668326 chr7:98998153 G/A cg09045935 chr12:6379348 NA 1.0 7.62 0.39 2.79e-13 Blood metabolite levels; CRC cis rs12550646 0.652 rs10090395 chr8:41666874 C/T cg12180191 chr8:41686706 ANK1 0.44 6.38 0.33 6.04e-10 Reticulocyte fraction of red cells;Reticulocyte count; CRC cis rs422249 0.547 rs174535 chr11:61551356 T/C cg00603274 chr11:61596626 FADS2 -0.45 -6.6 -0.34 1.62e-10 Trans fatty acid levels; CRC cis rs7819412 0.807 rs4840542 chr8:10944809 G/T cg27411982 chr8:10470053 RP1L1 -0.41 -6.41 -0.33 5.09e-10 Triglycerides; CRC cis rs1965732 0.958 rs6755529 chr2:3711972 C/T cg19052272 chr2:3704530 ALLC 0.52 7.51 0.38 5.72e-13 Response to inhaled corticosteroid treatment in asthma (change in FEV1); CRC cis rs731174 0.722 rs553888 chr1:38152509 C/G cg22449745 chr1:38156939 CDCA8;C1orf109 -0.3 -5.63 -0.3 3.95e-8 Prostate cancer (SNP x SNP interaction); CRC trans rs66887589 0.967 rs7678973 chr4:120511817 T/C cg25214090 chr10:38739885 LOC399744 -0.41 -6.38 -0.33 6.13e-10 Diastolic blood pressure; CRC cis rs1045714 0.895 rs4721860 chr7:2639994 C/T cg24848437 chr7:2645542 IQCE 0.58 6.13 0.32 2.45e-9 Urate levels in lean individuals; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg19191357 chr22:42196520 CCDC134 0.43 7.13 0.37 6.33e-12 Liver disease severity in Alagille syndrome; CRC cis rs9491140 0.539 rs11154221 chr6:124675246 C/T cg22366943 chr6:124882293 NKAIN2 0.56 8.53 0.43 5.42e-16 Neuroticism; CRC cis rs9322193 0.884 rs7744105 chr6:150170444 A/G cg07701084 chr6:150067640 NUP43 0.47 6.59 0.34 1.76e-10 Lung cancer; CRC cis rs1005277 0.563 rs2505215 chr10:38481273 A/G cg25427524 chr10:38739819 LOC399744 -0.77 -13.75 -0.6 2.69e-34 Extrinsic epigenetic age acceleration; CRC trans rs6076960 0.623 rs6038407 chr20:6267326 A/G cg21095983 chr6:86352623 SYNCRIP 0.57 8.08 0.41 1.26e-14 Smooth-surface caries; CRC cis rs727505 1.000 rs66922607 chr7:124512555 T/A cg23710748 chr7:124431027 NA -0.85 -15.05 -0.64 2.7e-39 Lewy body disease; CRC cis rs8060686 0.623 rs74024145 chr16:68153382 G/C cg26727032 chr16:67993705 SLC12A4 -0.62 -9.66 -0.47 1.32e-19 HDL cholesterol;Metabolic syndrome; CRC cis rs2115630 0.755 rs7169629 chr15:85191274 C/G cg12501888 chr15:85177176 SCAND2 0.42 6.99 0.36 1.57e-11 P wave terminal force; CRC cis rs10504229 0.775 rs72650876 chr8:58161638 G/A cg02725872 chr8:58115012 NA -0.6 -9.17 -0.45 5.2e-18 Developmental language disorder (linguistic errors); CRC cis rs4713675 0.546 rs791903 chr6:33702645 G/C cg14003231 chr6:33640908 ITPR3 -0.42 -6.94 -0.36 2.13e-11 Plateletcrit; CRC cis rs1799949 1.000 rs2037075 chr17:41305826 G/T cg25072359 chr17:41440525 NA 0.45 6.65 0.34 1.24e-10 Menopause (age at onset); CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg16682046 chr11:82612617 PRCP;C11orf82 -0.57 -7.13 -0.37 6.54e-12 Diisocyanate-induced asthma; CRC cis rs4665809 1.000 rs1550381 chr2:26266946 A/G cg26119090 chr2:26468346 HADHA;HADHB -0.62 -7.99 -0.4 2.23e-14 Gut microbiome composition (summer); CRC cis rs13098911 0.540 rs6791016 chr3:46074858 G/A cg12691230 chr3:46064611 XCR1 -0.52 -5.62 -0.3 4.01e-8 Celiac disease; CRC cis rs7692995 0.925 rs12513171 chr4:17997541 T/C cg08925142 chr4:18023851 LCORL -0.54 -6.03 -0.32 4.31e-9 Height; CRC cis rs6951245 1.000 rs111899361 chr7:1112348 C/T cg18402987 chr7:1209562 NA 0.67 7.18 0.37 4.7e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs10791097 0.694 rs4456262 chr11:130755813 C/T cg12179176 chr11:130786555 SNX19 -0.77 -12.86 -0.58 6.04e-31 Autism spectrum disorder or schizophrenia;Schizophrenia; CRC trans rs2303319 0.504 rs2389549 chr2:162462209 C/T cg18122310 chr12:50236657 BCDIN3D 0.72 6.11 0.32 2.8e-9 Cognitive function; CRC cis rs2276314 0.512 rs7234973 chr18:33450336 A/G cg19628046 chr18:33552617 C18orf21 0.4 5.89 0.31 9.37e-9 Endometriosis;Drug-induced torsades de pointes; CRC cis rs826838 0.874 rs11183816 chr12:38834656 T/G cg13010199 chr12:38710504 ALG10B 0.46 5.98 0.31 5.88e-9 Heart rate; CRC cis rs4363385 0.553 rs41263664 chr1:152974063 G/A cg25856811 chr1:152973957 SPRR3 -0.23 -6.01 -0.31 4.84e-9 Inflammatory skin disease; CRC cis rs35883536 0.545 rs56674564 chr1:101097718 T/C cg14515779 chr1:101123966 NA -0.33 -5.74 -0.3 2.19e-8 Monocyte count; CRC cis rs67311347 1.000 rs7642552 chr3:40424816 T/C cg24209194 chr3:40518798 ZNF619 0.4 5.89 0.31 9.44e-9 Renal cell carcinoma; CRC cis rs739401 0.611 rs10833048 chr11:3020040 A/G cg08508325 chr11:3079039 CARS -0.5 -9.09 -0.45 9.32e-18 Longevity; CRC cis rs2243480 1.000 rs59794892 chr7:65415873 G/A cg12463550 chr7:65579703 CRCP 0.62 5.95 0.31 6.75e-9 Diabetic kidney disease; CRC cis rs4926298 1.000 rs1077151 chr19:13151108 A/G cg11738485 chr19:12877000 HOOK2 -0.45 -6.11 -0.32 2.84e-9 Bipolar disorder; CRC cis rs501120 0.584 rs545025 chr10:44736544 C/T cg09554077 chr10:44749378 NA 0.76 8.38 0.42 1.59e-15 Coronary artery disease;Coronary heart disease; CRC cis rs11997175 0.574 rs4538830 chr8:33653741 C/G ch.8.33884649F chr8:33765107 NA 0.47 7.62 0.39 2.73e-13 Body mass index; CRC cis rs11997175 0.583 rs66622174 chr8:33812542 T/G ch.8.33884649F chr8:33765107 NA 0.42 5.68 0.3 2.98e-8 Body mass index; CRC cis rs2832077 0.527 rs11088095 chr21:30223188 A/T cg24692254 chr21:30365293 RNF160 -0.45 -6.69 -0.35 9.81e-11 Cognitive test performance; CRC trans rs12699921 0.632 rs2723494 chr7:17853983 C/T cg02066331 chr6:17282778 RBM24 -0.35 -6.11 -0.32 2.89e-9 Fibrinogen levels; CRC cis rs73195822 0.614 rs73194057 chr12:111216913 T/C cg12870014 chr12:110450643 ANKRD13A 0.75 10.22 0.49 1.73e-21 Itch intensity from mosquito bite; CRC cis rs9527 0.830 rs11191442 chr10:104643596 T/A cg04362960 chr10:104952993 NT5C2 0.64 8.38 0.42 1.6e-15 Arsenic metabolism; CRC cis rs875971 0.862 rs949930 chr7:65766822 C/G cg00343986 chr7:65444356 GUSB -0.4 -5.69 -0.3 2.88e-8 Aortic root size; CRC cis rs6121246 0.909 rs4518038 chr20:30419051 A/G cg13852791 chr20:30311386 BCL2L1 0.69 9.71 0.47 8.87e-20 Mean corpuscular hemoglobin; CRC cis rs9311474 0.508 rs17052256 chr3:52593119 A/G cg08222913 chr3:52553049 STAB1 -0.34 -6.46 -0.34 3.7e-10 Electroencephalogram traits; CRC cis rs2180341 0.566 rs982306 chr6:127777039 T/C cg27446573 chr6:127587934 RNF146 0.57 7.48 0.38 6.85e-13 Breast cancer; CRC cis rs6952808 0.582 rs10479762 chr7:2045351 T/C cg14004847 chr7:1930337 MAD1L1 0.42 6.03 0.32 4.3e-9 Bipolar disorder and schizophrenia; CRC cis rs7107174 1.000 rs114142124 chr11:78047537 T/C cg02023728 chr11:77925099 USP35 0.49 7.52 0.38 5.16e-13 Testicular germ cell tumor; CRC cis rs7264396 0.887 rs224419 chr20:34143092 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.49 -8.02 -0.4 1.82e-14 Total cholesterol levels; CRC cis rs72730918 0.590 rs8027162 chr15:51985147 T/C cg14296394 chr15:51910925 DMXL2 -0.43 -5.79 -0.3 1.63e-8 Intelligence (multi-trait analysis); CRC cis rs425277 0.606 rs262663 chr1:2084598 T/C cg21194808 chr1:2205498 SKI 0.38 5.78 0.3 1.75e-8 Height; CRC cis rs6912958 0.547 rs451089 chr6:88041859 A/G cg08069147 chr6:88032118 GJB7;C6orf162 0.71 11.47 0.53 7.76e-26 Monocyte percentage of white cells; CRC cis rs13118159 0.573 rs7664763 chr4:1352305 A/G cg02018176 chr4:1364513 KIAA1530 0.71 12.22 0.56 1.45e-28 Longevity; CRC cis rs2991971 0.967 rs2356551 chr1:46009318 C/T cg24296786 chr1:45957014 TESK2 0.57 8.59 0.43 3.56e-16 High light scatter reticulocyte count; CRC cis rs12451471 0.559 rs34746710 chr17:78079224 G/A cg20811857 chr17:78079795 GAA -0.46 -6.77 -0.35 6.01e-11 Plateletcrit;Mean corpuscular hemoglobin concentration; CRC cis rs2013441 0.965 rs1544421 chr17:20114217 T/C cg13482628 chr17:19912719 NA -0.42 -6.57 -0.34 1.95e-10 Obesity-related traits; CRC cis rs9491140 0.539 rs11154231 chr6:124687586 T/C cg19267163 chr6:125004984 NKAIN2 0.44 6.06 0.32 3.78e-9 Neuroticism; CRC cis rs1348850 0.632 rs12471621 chr2:178502353 T/C cg22681709 chr2:178499509 PDE11A -0.5 -9.32 -0.46 1.79e-18 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC trans rs2303319 0.504 rs62189046 chr2:162612371 C/G cg23919916 chr10:103825097 HPS6 -0.69 -6.01 -0.31 4.8e-9 Cognitive function; CRC cis rs9467711 0.606 rs2072803 chr6:26392515 G/C cg12315302 chr6:26189340 HIST1H4D 0.86 6.63 0.34 1.34e-10 Autism spectrum disorder or schizophrenia; CRC trans rs10242455 0.702 rs2293256 chr7:99057701 A/G cg09045935 chr12:6379348 NA -1.07 -9.0 -0.44 1.91e-17 Blood metabolite levels; CRC cis rs10504229 0.728 rs17215621 chr8:58152706 C/A cg21724239 chr8:58056113 NA 0.62 8.38 0.42 1.51e-15 Developmental language disorder (linguistic errors); CRC cis rs939658 0.805 rs35318825 chr15:79447098 C/A cg17916960 chr15:79447300 NA -0.44 -7.34 -0.38 1.65e-12 Refractive error; CRC cis rs9640161 0.673 rs34489187 chr7:150044379 G/A cg13722127 chr7:150037890 RARRES2 0.47 7.1 0.36 7.74e-12 Blood protein levels;Circulating chemerin levels; CRC cis rs10504229 0.683 rs56741275 chr8:58136108 C/G cg05313129 chr8:58192883 C8orf71 -0.43 -6.11 -0.32 2.74e-9 Developmental language disorder (linguistic errors); CRC cis rs1552244 1.000 rs35198334 chr3:10104553 G/C cg13047869 chr3:10149882 C3orf24 0.59 7.95 0.4 2.94e-14 Alzheimer's disease; CRC cis rs950169 1.000 rs62026530 chr15:84775840 G/T cg24253500 chr15:84953950 NA 0.38 6.48 0.34 3.43e-10 Schizophrenia; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg02970861 chr11:62359288 TUT1 0.47 6.52 0.34 2.71e-10 Response to antipsychotic treatment; CRC cis rs427394 0.582 rs274665 chr5:6707981 C/T cg15145174 chr5:6755386 POLS -0.46 -6.44 -0.33 4.16e-10 Menopause (age at onset); CRC cis rs736408 0.527 rs2577831 chr3:52628056 C/A cg15147215 chr3:52552868 STAB1 -0.7 -13.11 -0.59 6.97e-32 Bipolar disorder; CRC cis rs9733 0.566 rs11204675 chr1:150570985 A/C cg18016565 chr1:150552671 MCL1 -0.48 -7.65 -0.39 2.25e-13 Tonsillectomy; CRC cis rs2576037 0.526 rs4890707 chr18:44497724 C/G cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.55 9.21 0.45 3.84e-18 Personality dimensions; CRC cis rs9303280 0.901 rs12103884 chr17:38045725 C/T cg00129232 chr17:37814104 STARD3 -0.46 -7.08 -0.36 8.59e-12 Self-reported allergy; CRC trans rs17374222 0.606 rs11854396 chr15:70036589 G/A cg15808008 chr15:89764895 RLBP1 -0.29 -6.08 -0.32 3.31e-9 Rheumatoid arthritis; CRC cis rs9910055 0.529 rs228749 chr17:42174570 A/G cg09913183 chr17:42254507 C17orf65;ASB16 -0.5 -6.8 -0.35 4.81e-11 Total body bone mineral density; CRC cis rs2303759 0.874 rs10411630 chr19:49891314 C/A cg22590775 chr19:49891494 CCDC155 0.65 9.17 0.45 5.22e-18 Multiple sclerosis; CRC trans rs13046373 0.905 rs4816372 chr21:32077414 A/T cg25010444 chr12:123717480 C12orf65 -0.41 -5.99 -0.31 5.65e-9 HDL cholesterol; CRC cis rs1552244 0.572 rs66514627 chr3:10166632 A/C cg00166722 chr3:10149974 C3orf24 0.65 7.7 0.39 1.56e-13 Alzheimer's disease; CRC cis rs6502050 0.835 rs4641801 chr17:80154021 G/A cg19223190 chr17:80058835 NA 0.4 6.4 0.33 5.26e-10 Life satisfaction; CRC cis rs3806843 0.771 rs2563336 chr5:140107199 A/G cg26395211 chr5:140044315 WDR55 0.38 5.68 0.3 2.99e-8 Depressive symptoms (multi-trait analysis); CRC cis rs2880765 0.835 rs11633604 chr15:86031579 T/G cg17133734 chr15:86042851 AKAP13 0.43 6.73 0.35 7.69e-11 Coronary artery disease; CRC trans rs66573146 1.000 rs73088528 chr4:6967747 G/C cg07817883 chr1:32538562 TMEM39B 1.46 13.16 0.59 4.47e-32 Granulocyte percentage of myeloid white cells; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg06465160 chr1:25071620 CLIC4 0.43 6.12 0.32 2.65e-9 Intelligence (multi-trait analysis); CRC cis rs34779708 0.931 rs17583009 chr10:35320915 T/C cg03585969 chr10:35415529 CREM 0.65 8.64 0.43 2.46e-16 Inflammatory bowel disease;Crohn's disease; CRC cis rs9487051 0.714 rs6902892 chr6:109627601 G/T cg12927641 chr6:109611667 NA -0.34 -6.09 -0.32 3.09e-9 Reticulocyte fraction of red cells; CRC cis rs728616 0.558 rs12767261 chr10:82162323 G/A cg05935833 chr10:81318306 SFTPA2 -0.58 -6.97 -0.36 1.74e-11 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs45509595 0.822 rs200484 chr6:27775674 A/G cg15845792 chr6:28175446 NA 0.72 6.18 0.32 1.9e-9 Breast cancer; CRC trans rs66759488 0.739 rs10851451 chr15:47608991 A/G cg20590175 chr12:132530165 EP400 -0.41 -6.01 -0.31 4.95e-9 Lung cancer; CRC trans rs60843830 1.000 rs55936726 chr2:258210 T/C cg11347411 chr7:150020925 ACTR3C;LRRC61 0.59 9.19 0.45 4.51e-18 Spherical equivalent (joint analysis main effects and education interaction); CRC cis rs9398803 0.865 rs1538171 chr6:126752884 C/G cg19875578 chr6:126661172 C6orf173 0.42 5.76 0.3 1.91e-8 Male-pattern baldness; CRC cis rs12291225 0.679 rs11023178 chr11:14310282 G/A cg19336497 chr11:14380999 RRAS2 -0.52 -8.58 -0.43 3.89e-16 Sense of smell; CRC cis rs6582630 0.555 rs10880544 chr12:38473464 G/C cg13010199 chr12:38710504 ALG10B 0.49 6.58 0.34 1.87e-10 Drug-induced liver injury (flucloxacillin); CRC cis rs1150668 0.835 rs1233696 chr6:28143010 T/C cg03623178 chr6:28175578 NA 0.66 10.08 0.49 5.38e-21 Pubertal anthropometrics; CRC cis rs6952808 1.000 rs59248873 chr7:1888185 A/G cg00106254 chr7:1943704 MAD1L1 -0.41 -6.04 -0.32 4.26e-9 Bipolar disorder and schizophrenia; CRC trans rs492478 0.892 rs11959334 chr5:3942641 C/T cg09199442 chr11:28132951 METT5D1 -0.72 -6.42 -0.33 4.89e-10 Cognitive performance; CRC cis rs7772486 0.719 rs4391282 chr6:146276780 A/T cg13319975 chr6:146136371 FBXO30 0.38 5.79 0.3 1.62e-8 Lobe attachment (rater-scored or self-reported); CRC cis rs4862750 0.872 rs6830828 chr4:187897472 T/G cg03647317 chr4:187891568 NA -0.53 -9.9 -0.48 2.14e-20 Lobe attachment (rater-scored or self-reported); CRC cis rs5167 0.525 rs11083752 chr19:45454363 G/A cg13119609 chr19:45449297 APOC2 0.31 5.81 0.3 1.5e-8 Blood protein levels; CRC cis rs738322 0.600 rs6001030 chr22:38555904 T/G cg25457927 chr22:38595422 NA -0.29 -5.68 -0.3 2.93e-8 Cutaneous nevi; CRC cis rs7613875 0.521 rs4688754 chr3:50074641 G/T cg24110177 chr3:50126178 RBM5 0.53 7.94 0.4 3.21e-14 Body mass index; CRC cis rs965469 1.000 rs1331215 chr20:3376565 T/C cg25506879 chr20:3388711 C20orf194 -0.4 -5.84 -0.31 1.27e-8 IFN-related cytopenia; CRC cis rs908922 0.651 rs1988805 chr1:152531495 T/G cg09873164 chr1:152488093 CRCT1 0.36 6.16 0.32 2.14e-9 Hair morphology; CRC cis rs1728785 1.000 rs1170436 chr16:68607486 T/A cg02972257 chr16:68554789 NA -0.6 -7.28 -0.37 2.46e-12 Ulcerative colitis; CRC cis rs28386778 0.897 rs894407 chr17:61901641 T/C cg07362569 chr17:61921086 SMARCD2 0.38 5.95 0.31 6.87e-9 Prudent dietary pattern; CRC cis rs4664293 0.867 rs7582124 chr2:160572837 T/C cg08347373 chr2:160653686 CD302 -0.47 -7.45 -0.38 8.04e-13 Monocyte percentage of white cells; CRC trans rs7395662 1.000 rs7121460 chr11:48545232 C/A cg21153622 chr11:89784906 NA -0.48 -7.64 -0.39 2.36e-13 HDL cholesterol; CRC cis rs12908161 1.000 rs4643294 chr15:85250253 C/T cg17507749 chr15:85114479 UBE2QP1 0.63 8.87 0.44 4.91e-17 Schizophrenia; CRC cis rs933688 0.938 rs12110065 chr5:90718474 A/G cg02339078 chr5:90679543 LOC100129716;ARRDC3 0.93 14.39 0.62 9.04e-37 Smoking behavior; CRC cis rs1218582 0.600 rs72702224 chr1:154911689 G/A cg16680214 chr1:154839983 KCNN3 -0.49 -8.76 -0.43 1.06e-16 Prostate cancer; CRC cis rs1799949 1.000 rs4792981 chr17:41308274 A/G cg05368731 chr17:41323189 NBR1 0.69 10.51 0.5 1.74e-22 Menopause (age at onset); CRC cis rs992157 0.710 rs6719789 chr2:219057810 G/T cg00012203 chr2:219082015 ARPC2 -0.6 -9.96 -0.48 1.31e-20 Colorectal cancer; CRC cis rs2762353 0.574 rs16890999 chr6:25755583 A/G cg12310025 chr6:25882481 NA 0.74 10.47 0.5 2.54e-22 Blood metabolite levels; CRC cis rs8072100 0.840 rs12452796 chr17:45479733 G/T cg08085267 chr17:45401833 C17orf57 0.65 10.77 0.51 2.34e-23 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs11792861 0.962 rs72607162 chr9:111793719 T/C cg05043794 chr9:111880884 C9orf5 -0.34 -6.34 -0.33 7.6e-10 Menarche (age at onset); CRC cis rs1218582 0.772 rs4845689 chr1:154885524 A/G cg03351412 chr1:154909251 PMVK 0.54 8.68 0.43 1.92e-16 Prostate cancer; CRC cis rs2576037 0.523 rs4890705 chr18:44509758 A/G cg07643061 chr18:44555308 TCEB3C;TCEB3CL;KATNAL2 -0.34 -5.62 -0.3 3.99e-8 Personality dimensions; CRC cis rs2282526 0.615 rs463738 chr21:44921166 G/A cg04455712 chr21:45112962 RRP1B -0.37 -6.32 -0.33 8.46e-10 Mean corpuscular hemoglobin; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg07145398 chr17:61523374 CYB561 0.39 6.01 0.31 4.94e-9 Liver disease severity in Alagille syndrome; CRC trans rs8108034 1.000 rs39587 chr19:39806997 C/T cg11542086 chr8:79716756 IL7 -0.53 -5.97 -0.31 6.22e-9 Lung adenocarcinoma; CRC cis rs7572644 0.699 rs13400398 chr2:28162109 C/T cg27432699 chr2:27873401 GPN1 -0.41 -5.69 -0.3 2.76e-8 Response to carboplatin and paclitaxel in ovarian cancer (Caspase 3/7 EC50); CRC cis rs78456975 1.000 rs6708604 chr2:1556887 C/T cg26248373 chr2:1572462 NA -0.65 -7.02 -0.36 1.24e-11 Placebo response in major depressive disorder (% change in symptom score); CRC cis rs7552404 0.924 rs7546641 chr1:76158035 T/C cg03433033 chr1:76189801 ACADM 0.92 14.18 0.62 5.85e-36 Blood metabolite levels;Acylcarnitine levels; CRC cis rs1322639 0.614 rs9689800 chr6:169572945 T/A cg04662567 chr6:169592167 NA 0.31 5.7 0.3 2.73e-8 Pulse pressure; CRC cis rs7584330 0.554 rs6740722 chr2:238393288 T/C cg14458575 chr2:238380390 NA 0.83 10.95 0.52 5.27e-24 Prostate cancer; CRC cis rs9858542 0.953 rs35169793 chr3:49423274 A/G cg03060546 chr3:49711283 APEH -0.48 -6.85 -0.35 3.71e-11 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs798554 0.959 rs798556 chr7:2759002 C/A cg17321639 chr7:2759063 NA -0.54 -7.52 -0.38 5.17e-13 Height; CRC cis rs12044355 0.927 rs66909551 chr1:231834942 C/T cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX 0.5 6.81 0.35 4.68e-11 Alzheimer's disease; CRC cis rs6502050 0.835 rs4789670 chr17:80151805 T/C cg19223190 chr17:80058835 NA 0.39 6.26 0.33 1.19e-9 Life satisfaction; CRC cis rs7258465 1.000 rs2007981 chr19:18567555 C/A cg01065977 chr19:18549689 ISYNA1 -0.41 -6.37 -0.33 6.28e-10 Breast cancer; CRC cis rs9443645 0.507 rs1475046 chr6:79461801 G/A cg05283184 chr6:79620031 NA -0.44 -7.38 -0.38 1.31e-12 Intelligence (multi-trait analysis); CRC cis rs2204008 0.683 rs12370288 chr12:38127740 G/A cg13010199 chr12:38710504 ALG10B 0.45 5.75 0.3 2.08e-8 Bladder cancer; CRC cis rs7772486 0.790 rs2254257 chr6:146203724 C/T cg23711669 chr6:146136114 FBXO30 0.72 12.76 0.58 1.44e-30 Lobe attachment (rater-scored or self-reported); CRC cis rs11148252 0.840 rs4369550 chr13:52744910 A/G cg00495681 chr13:53174319 NA 0.58 8.79 0.44 8.64e-17 Lewy body disease; CRC cis rs2839186 0.934 rs17182538 chr21:47705673 C/A cg09417038 chr21:47716443 C21orf57 -0.41 -6.75 -0.35 6.51e-11 Testicular germ cell tumor; CRC cis rs736408 0.509 rs3774349 chr3:52722335 A/C cg18099408 chr3:52552593 STAB1 -0.54 -9.78 -0.47 5.42e-20 Bipolar disorder; CRC cis rs7811142 0.830 rs76798830 chr7:99952828 C/T cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.13 15.39 0.65 1.27e-40 Platelet count; CRC cis rs4805272 0.539 rs1422212 chr19:29330191 T/A cg12667521 chr19:29218732 NA 0.43 5.75 0.3 2.05e-8 Plasma omega-3 polyunsaturated fatty acid levels (docosahexaenoic acid); CRC cis rs870825 0.655 rs67380800 chr4:185623788 T/C cg04058563 chr4:185651563 MLF1IP 0.72 9.36 0.46 1.32e-18 Blood protein levels; CRC cis rs13191362 1.000 rs35017019 chr6:162982581 A/G cg21926612 chr6:163149169 PACRG;PARK2 0.82 11.49 0.54 6.51e-26 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs3733585 0.673 rs7377578 chr4:9952775 T/C cg11266682 chr4:10021025 SLC2A9 -0.47 -9.62 -0.47 1.76e-19 Cleft plate (environmental tobacco smoke interaction); CRC cis rs1046896 1.000 rs1046917 chr17:80685655 A/G cg02398342 chr17:80708632 TBCD;FN3K -0.35 -5.65 -0.3 3.41e-8 Glycated hemoglobin levels; CRC cis rs9837602 0.872 rs35154249 chr3:99738230 G/A cg07805332 chr3:99536008 MIR548G;C3orf26 -0.49 -6.1 -0.32 3.05e-9 Breast cancer; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg04742047 chr19:14544036 PKN1 -0.38 -5.96 -0.31 6.38e-9 Myopia (pathological); CRC cis rs2153535 0.580 rs1414348 chr6:8471940 A/G cg07606381 chr6:8435919 SLC35B3 0.68 10.9 0.52 7.69e-24 Motion sickness; CRC cis rs1448094 0.512 rs57278040 chr12:86237886 A/G cg19622623 chr12:86230825 RASSF9 -0.42 -6.76 -0.35 6.21e-11 Major depressive disorder; CRC cis rs7613875 0.600 rs1061474 chr3:50144951 T/C cg05623727 chr3:50126028 RBM5 -0.62 -10.89 -0.51 8.94e-24 Body mass index; CRC cis rs8077889 1.000 rs8077889 chr17:41878166 G/T cg16892393 chr17:41919603 NA -0.49 -7.13 -0.37 6.37e-12 Triglycerides; CRC cis rs317865 0.609 rs73234660 chr4:16221047 G/C cg04764131 chr4:16228633 TAPT1;FLJ39653 0.67 6.06 0.32 3.71e-9 Kidney disease (early stage) in type 1 diabetes; CRC cis rs12900413 0.603 rs2882678 chr15:90299542 A/G cg24249390 chr15:90295951 MESP1 -0.56 -8.4 -0.42 1.34e-15 Coronary artery aneurysm in Kawasaki disease; CRC trans rs11098499 0.554 rs2175381 chr4:120265967 T/C cg25214090 chr10:38739885 LOC399744 0.53 8.51 0.42 6.36e-16 Corneal astigmatism; CRC cis rs4819052 0.851 rs4819038 chr21:46659393 C/T cg11663144 chr21:46675770 NA -0.83 -14.12 -0.61 9.88e-36 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg24810637 chr10:64564243 ADO 0.45 6.35 0.33 7.34e-10 Response to antipsychotic treatment; CRC cis rs72772090 0.539 rs11746534 chr5:96124807 G/A cg17330273 chr5:96107758 CAST;ERAP1 -0.63 -5.96 -0.31 6.43e-9 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs9611565 0.592 rs5758406 chr22:42076641 A/G cg06634786 chr22:41940651 POLR3H 0.52 6.13 0.32 2.47e-9 Vitiligo; CRC cis rs1401999 1.000 rs1402002 chr3:183642794 A/G cg20387954 chr3:183756860 HTR3D 0.43 7.37 0.38 1.35e-12 Anterior chamber depth; CRC cis rs4975616 0.804 rs462608 chr5:1336626 T/A cg26373071 chr5:1325741 CLPTM1L 0.5 8.97 0.44 2.23e-17 Lung cancer; CRC cis rs6879260 1.000 rs888922 chr5:179731635 C/G cg02891314 chr5:179741120 GFPT2 -0.7 -11.12 -0.52 1.32e-24 Height; CRC cis rs12760731 0.565 rs12403070 chr1:178094429 A/G cg00404053 chr1:178313656 RASAL2 1.08 11.21 0.53 6.52e-25 Obesity-related traits; CRC cis rs4129767 0.869 rs4969142 chr17:76398304 G/A cg05887092 chr17:76393375 PGS1 0.65 12.59 0.57 6.35e-30 HDL cholesterol; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg16266895 chr12:101674004 UTP20 0.51 6.79 0.35 5.3e-11 Thyroid stimulating hormone; CRC cis rs950169 0.959 rs66801143 chr15:84736657 C/T cg17507749 chr15:85114479 UBE2QP1 0.77 11.93 0.55 1.64e-27 Schizophrenia; CRC cis rs1448094 0.512 rs4488288 chr12:86245450 A/C cg18827107 chr12:86230957 RASSF9 -0.45 -7.42 -0.38 9.97e-13 Major depressive disorder; CRC cis rs2346160 0.899 rs384974 chr6:167688418 C/T cg04673565 chr6:167680447 NA -0.39 -6.58 -0.34 1.8e-10 Parental extreme longevity (95 years and older); CRC cis rs3806843 1.000 rs13157397 chr5:140184442 G/A cg16607685 chr5:140181889 PCDHA2;PCDHA1;PCDHA3 -0.25 -5.8 -0.3 1.57e-8 Depressive symptoms (multi-trait analysis); CRC cis rs926938 0.527 rs360672 chr1:115483836 C/T cg12756093 chr1:115239321 AMPD1 0.48 6.96 0.36 1.84e-11 Autism; CRC cis rs10504229 0.906 rs72650894 chr8:58179734 C/T cg02725872 chr8:58115012 NA -0.38 -6.43 -0.33 4.44e-10 Developmental language disorder (linguistic errors); CRC cis rs10504229 0.638 rs6981055 chr8:58113941 T/C cg04204079 chr8:58130323 NA -0.45 -5.84 -0.31 1.27e-8 Developmental language disorder (linguistic errors); CRC trans rs561341 0.783 rs512698 chr17:30292507 G/T cg20587970 chr11:113659929 NA -1.43 -20.42 -0.75 2e-60 Hip circumference adjusted for BMI; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg00119011 chr13:45694603 GTF2F2 0.43 6.11 0.32 2.78e-9 Anxiety disorder; CRC cis rs7666738 0.830 rs62318472 chr4:98926030 G/A cg05340658 chr4:99064831 C4orf37 0.58 8.76 0.43 1.04e-16 Colonoscopy-negative controls vs population controls; CRC cis rs4727027 0.933 rs9718383 chr7:148857624 A/T cg12479418 chr7:148823350 ZNF425;ZNF398 -0.43 -5.85 -0.31 1.19e-8 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC cis rs10992471 0.603 rs12341817 chr9:95252152 C/T cg14631576 chr9:95140430 CENPP -0.39 -6.79 -0.35 5.16e-11 Visceral adipose tissue/subcutaneous adipose tissue ratio; CRC cis rs9640161 0.750 rs3800780 chr7:150027284 C/A cg12556325 chr7:150026731 C7orf29;LRRC61 -0.47 -6.93 -0.36 2.19e-11 Blood protein levels;Circulating chemerin levels; CRC cis rs909002 0.800 rs7529064 chr1:32105192 C/A cg13919466 chr1:32135498 COL16A1 -0.32 -5.99 -0.31 5.64e-9 Intelligence (multi-trait analysis); CRC cis rs9768139 0.935 rs7782393 chr7:158120486 G/A cg06219351 chr7:158114137 PTPRN2 0.44 6.65 0.34 1.23e-10 Calcium levels; CRC cis rs972578 1.000 rs1569507 chr22:43356699 A/G cg01576275 chr22:43409880 NA 0.44 6.73 0.35 7.7e-11 Mean platelet volume; CRC cis rs6545883 1.000 rs778762 chr2:61782921 G/T cg15711740 chr2:61764176 XPO1 -0.51 -7.03 -0.36 1.22e-11 Tuberculosis; CRC cis rs7089973 0.584 rs7908665 chr10:116611337 G/A cg23260525 chr10:116636907 FAM160B1 0.39 9.25 0.45 2.85e-18 Bipolar disorder or attention deficit hyperactivity disorder; CRC trans rs7395662 0.611 rs7478698 chr11:48549139 T/C cg03929089 chr4:120376271 NA -0.46 -6.52 -0.34 2.69e-10 HDL cholesterol; CRC cis rs7927771 0.864 rs112060627 chr11:47426956 G/A cg18512352 chr11:47633146 NA -0.42 -8.09 -0.41 1.2e-14 Subjective well-being; CRC trans rs1728785 1.000 rs1099296 chr16:68588653 G/A cg04657470 chr2:198365150 HSPE1;HSPD1 0.59 7.1 0.36 7.97e-12 Ulcerative colitis; CRC cis rs9875589 0.915 rs62234597 chr3:13963780 G/A cg19554555 chr3:13937349 NA 0.44 6.34 0.33 7.58e-10 Ovarian reserve; CRC trans rs7267979 0.753 rs400357 chr20:25479058 A/G cg17903999 chr18:56338584 MALT1 -0.38 -6.17 -0.32 1.96e-9 Liver enzyme levels (alkaline phosphatase); CRC cis rs6598955 0.670 rs11247892 chr1:26592727 A/G cg04990556 chr1:26633338 UBXN11 -0.78 -13.26 -0.59 1.9e-32 Obesity-related traits; CRC cis rs9462027 0.628 rs9296131 chr6:34776361 C/T cg07306190 chr6:34760872 UHRF1BP1 -0.34 -5.97 -0.31 6.31e-9 Systemic lupus erythematosus; CRC cis rs6504622 0.537 rs1662594 chr17:44992737 C/T cg16759221 chr17:45003025 GOSR2 -0.63 -10.47 -0.5 2.45e-22 Orofacial clefts; CRC cis rs10779751 0.708 rs2746640 chr1:11292952 T/A cg08854313 chr1:11322531 MTOR 0.64 8.87 0.44 4.69e-17 Body mass index; CRC cis rs9467160 1.000 rs9467161 chr6:24441963 C/T cg20631270 chr6:24437470 GPLD1 0.48 6.34 0.33 7.61e-10 Liver enzyme levels; CRC cis rs10782582 0.609 rs5745410 chr1:76314356 C/A cg03433033 chr1:76189801 ACADM -0.41 -5.79 -0.3 1.63e-8 Daytime sleep phenotypes; CRC cis rs6748734 0.817 rs4465762 chr2:241798862 G/A cg04034577 chr2:241836375 C2orf54 -0.35 -7.47 -0.38 7.51e-13 Urinary metabolites; CRC cis rs116095464 0.558 rs2288459 chr5:231143 T/C cg22496380 chr5:211416 CCDC127 -0.85 -9.93 -0.48 1.71e-20 Breast cancer; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg14431266 chr11:67057003 ANKRD13D 0.44 6.36 0.33 6.57e-10 Intelligence (multi-trait analysis); CRC cis rs3733585 0.699 rs6844316 chr4:9958977 A/G cg00071950 chr4:10020882 SLC2A9 -0.54 -9.65 -0.47 1.42e-19 Cleft plate (environmental tobacco smoke interaction); CRC cis rs853679 0.517 rs9368553 chr6:28082265 T/C cg02683197 chr6:28174875 NA 0.85 10.27 0.49 1.16e-21 Depression; CRC cis rs936229 0.768 rs936226 chr15:75069282 C/T cg14664628 chr15:75095509 CSK -1.01 -19.19 -0.73 1.29e-55 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); CRC cis rs769267 0.930 rs9917108 chr19:19572785 A/G cg01262667 chr19:19385393 TM6SF2 0.36 5.84 0.31 1.25e-8 Tonsillectomy; CRC cis rs28386778 0.799 rs2584612 chr17:61932204 A/G cg06873352 chr17:61820015 STRADA 0.73 13.62 0.6 8.27e-34 Prudent dietary pattern; CRC cis rs9322193 0.884 rs10872648 chr6:150079835 A/G cg07701084 chr6:150067640 NUP43 0.54 7.44 0.38 8.71e-13 Lung cancer; CRC cis rs889398 0.802 rs8051168 chr16:69887274 T/A cg00738113 chr16:70207722 CLEC18C -0.37 -6.27 -0.33 1.12e-9 Body mass index; CRC cis rs10751667 0.666 rs10902239 chr11:946484 A/G cg23136738 chr11:925521 AP2A2 0.42 7.14 0.37 5.96e-12 Alzheimer's disease (late onset); CRC cis rs11190604 0.767 rs77769532 chr10:102193646 T/C cg07080220 chr10:102295463 HIF1AN 0.5 6.31 0.33 9.07e-10 Palmitoleic acid (16:1n-7) levels; CRC cis rs4665809 1.000 rs4665817 chr2:26305167 G/A cg27170947 chr2:26402098 FAM59B -0.45 -5.72 -0.3 2.43e-8 Gut microbiome composition (summer); CRC cis rs12477438 0.798 rs1580068 chr2:99649969 T/C cg14399236 chr2:99771627 LIPT1;TSGA10 -0.74 -10.37 -0.5 5.51e-22 Chronic sinus infection; CRC cis rs2836950 0.501 rs2056844 chr21:40670460 G/C cg06238570 chr21:40685208 BRWD1 -0.6 -8.71 -0.43 1.51e-16 Menarche (age at onset); CRC cis rs72634258 0.945 rs12740409 chr1:8027830 A/C cg26816564 chr1:7831052 VAMP3 0.61 6.52 0.34 2.65e-10 Inflammatory bowel disease; CRC cis rs12477438 0.765 rs56167745 chr2:99600478 T/A cg14399236 chr2:99771627 LIPT1;TSGA10 -0.6 -8.32 -0.42 2.45e-15 Chronic sinus infection; CRC cis rs4332037 0.575 rs55952733 chr7:2070680 G/A cg23378565 chr7:2036160 MAD1L1 -0.43 -6.15 -0.32 2.26e-9 Bipolar disorder; CRC cis rs12024301 0.557 rs115011681 chr1:183619683 G/A cg11505048 chr1:183622726 RGL1;APOBEC4 0.81 7.12 0.37 6.85e-12 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs7605827 0.930 rs1990753 chr2:15612403 G/C cg19274914 chr2:15703543 NA 0.39 5.9 0.31 8.83e-9 Educational attainment (years of education); CRC cis rs1215050 0.791 rs11729826 chr4:98657190 G/T cg05340658 chr4:99064831 C4orf37 -0.47 -7.01 -0.36 1.4e-11 Waist-to-hip ratio adjusted for body mass index; CRC cis rs10089 1.000 rs11957052 chr5:127524055 T/C cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.68 9.25 0.45 2.86e-18 Ileal carcinoids; CRC cis rs4713118 0.629 rs203887 chr6:28021269 C/T cg25164649 chr6:28176230 NA 0.6 7.45 0.38 8.36e-13 Parkinson's disease; CRC cis rs1862618 0.853 rs832582 chr5:56177743 G/A cg03609598 chr5:56110824 MAP3K1 -0.85 -10.06 -0.49 6.18e-21 Initial pursuit acceleration; CRC cis rs736408 0.608 rs4687657 chr3:52852538 G/T cg11645453 chr3:52864694 ITIH4 0.56 9.76 0.47 6.35e-20 Bipolar disorder; CRC cis rs12368653 1.000 rs12368653 chr12:58133256 A/G cg00677455 chr12:58241039 CTDSP2 0.54 8.13 0.41 8.79e-15 Multiple sclerosis; CRC cis rs2380220 0.872 rs115871915 chr6:95934180 T/C cg04719120 chr6:96025338 MANEA -0.55 -6.0 -0.31 5.09e-9 Behavioural disinhibition (generation interaction); CRC cis rs7927592 0.763 rs1193699 chr11:68249480 C/G cg01657329 chr11:68192670 LRP5 -0.53 -8.77 -0.44 9.6e-17 Total body bone mineral density; CRC cis rs6930083 0.605 rs3829964 chr6:36644498 T/C cg08179530 chr6:36648295 CDKN1A 0.75 12.41 0.56 2.98e-29 Coronary artery disease; CRC cis rs6504663 0.525 rs557 chr17:48563234 C/T cg00901687 chr17:48585270 MYCBPAP 0.42 5.62 0.3 4.16e-8 Visceral fat; CRC cis rs12472274 0.648 rs67102443 chr2:239084602 A/G cg17459225 chr2:239074497 NA 0.65 11.2 0.53 7.2e-25 Phospholipid levels (plasma); CRC cis rs1552244 1.000 rs6768102 chr3:10149380 A/G cg02579736 chr3:10068473 FANCD2;CIDECP 1.02 13.61 0.6 8.9e-34 Alzheimer's disease; CRC cis rs4731207 0.596 rs6971179 chr7:124592351 G/A cg23710748 chr7:124431027 NA -0.43 -6.81 -0.35 4.56e-11 Cutaneous malignant melanoma; CRC cis rs7917772 0.560 rs11595170 chr10:104339851 T/C cg11453585 chr10:104263688 ACTR1A;SUFU -0.83 -14.99 -0.64 4.54e-39 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC cis rs2495707 0.624 rs2489006 chr10:102419893 G/A cg22689833 chr10:102415991 NA -0.32 -6.19 -0.32 1.82e-9 Body mass index; CRC cis rs10504229 0.683 rs16921808 chr8:58106049 C/T cg05313129 chr8:58192883 C8orf71 -0.46 -6.09 -0.32 3.15e-9 Developmental language disorder (linguistic errors); CRC cis rs713587 0.713 rs11682135 chr2:25205377 G/A cg22495460 chr2:25135724 ADCY3 0.67 11.12 0.52 1.38e-24 Body mass index in non-asthmatics; CRC cis rs853679 0.517 rs9368556 chr6:28131153 T/C cg02683197 chr6:28174875 NA 0.87 10.73 0.51 3.25e-23 Depression; CRC cis rs76878669 0.561 rs1784029 chr11:66099987 C/T cg24851651 chr11:66362959 CCS -0.37 -6.58 -0.34 1.91e-10 Educational attainment (years of education); CRC cis rs2836950 0.501 rs11088470 chr21:40689162 A/G cg06238570 chr21:40685208 BRWD1 -0.6 -8.64 -0.43 2.48e-16 Menarche (age at onset); CRC cis rs17270561 0.609 rs9358876 chr6:25738956 A/G cg17691542 chr6:26056736 HIST1H1C 0.73 9.26 0.45 2.71e-18 Iron status biomarkers; CRC cis rs5769765 0.862 rs9616384 chr22:50313082 C/T cg08270630 chr22:50330655 NA -0.4 -5.61 -0.3 4.4e-8 Schizophrenia; CRC cis rs11627756 0.918 rs2403070 chr14:103093432 T/C cg12046867 chr14:103022105 NA -0.41 -5.62 -0.3 4.02e-8 Mean platelet volume; CRC cis rs977987 0.872 rs7206665 chr16:75475287 A/C cg03315344 chr16:75512273 CHST6 0.53 9.07 0.45 1.12e-17 Dupuytren's disease; CRC cis rs2836950 0.501 rs2836983 chr21:40689336 G/A cg11890956 chr21:40555474 PSMG1 -0.61 -8.99 -0.44 1.95e-17 Menarche (age at onset); CRC cis rs57221529 0.766 rs28563961 chr5:554498 C/G cg09021430 chr5:549028 NA -0.72 -7.92 -0.4 3.64e-14 Lung disease severity in cystic fibrosis; CRC cis rs4862750 0.915 rs6835681 chr4:187903476 A/G cg10295955 chr4:187884368 NA -1.07 -27.76 -0.84 3.21e-88 Lobe attachment (rater-scored or self-reported); CRC cis rs11628318 0.763 rs11623312 chr14:103022060 G/T cg08075719 chr14:103021372 NA -0.66 -8.62 -0.43 2.83e-16 Platelet count; CRC cis rs6543140 0.855 rs4851591 chr2:103077423 T/C cg04239558 chr2:103089729 SLC9A4 0.37 6.58 0.34 1.83e-10 Blood protein levels; CRC cis rs9349203 1 rs9349203 chr6:41893323 G/A cg17623882 chr6:41773611 USP49 -0.51 -8.33 -0.42 2.14e-15 Menarche (age at onset); CRC cis rs12928939 0.911 rs7202840 chr16:71824714 C/T cg03805757 chr16:71968109 PKD1L3 -0.47 -6.05 -0.32 4.04e-9 Post bronchodilator FEV1; CRC trans rs7615952 0.800 rs13086460 chr3:125646417 C/T cg16558177 chr4:4109446 NA -0.49 -6.26 -0.33 1.22e-9 Blood pressure (smoking interaction); CRC cis rs910316 1.000 rs12879542 chr14:75507525 C/T cg03030879 chr14:75389066 RPS6KL1 -0.45 -6.99 -0.36 1.57e-11 Height; CRC cis rs561341 0.883 rs4795661 chr17:30201774 T/A cg00745463 chr17:30367425 LRRC37B 0.69 8.07 0.41 1.31e-14 Hip circumference adjusted for BMI; CRC cis rs2280018 0.581 rs7404524 chr16:15129158 A/G cg27102117 chr16:15229624 NA 0.5 8.5 0.42 6.93e-16 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid);Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg09377915 chr6:56295593 NA -0.37 -6.09 -0.32 3.12e-9 Liver disease severity in Alagille syndrome; CRC cis rs79387448 0.745 rs59694233 chr2:103116521 G/A cg00507830 chr2:103233733 NA 0.51 5.8 0.3 1.55e-8 Gut microbiota (bacterial taxa); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg14893720 chr7:33149316 RP9 0.42 6.09 0.32 3.07e-9 Intelligence (multi-trait analysis); CRC cis rs709400 0.526 rs11622473 chr14:103979762 G/A cg07514618 chr14:103979422 NA -0.44 -6.77 -0.35 6.09e-11 Body mass index; CRC cis rs72781680 0.611 rs56326157 chr2:24312407 T/C cg20701182 chr2:24300061 SF3B14 0.67 7.75 0.39 1.15e-13 Lymphocyte counts; CRC cis rs7918232 0.882 rs2149413 chr10:27430311 C/T cg14240646 chr10:27532245 ACBD5 0.81 9.18 0.45 4.9e-18 Breast cancer; CRC cis rs4731207 0.596 rs2017928 chr7:124672323 A/G cg23710748 chr7:124431027 NA -0.39 -6.16 -0.32 2.07e-9 Cutaneous malignant melanoma; CRC cis rs9487051 0.639 rs2884012 chr6:109598221 C/T cg01475377 chr6:109611718 NA -0.37 -6.58 -0.34 1.85e-10 Reticulocyte fraction of red cells; CRC cis rs17253792 0.822 rs111467375 chr14:56046159 T/G cg01858014 chr14:56050164 KTN1 -0.88 -7.09 -0.36 8.36e-12 Putamen volume; CRC cis rs17401966 0.597 rs11121555 chr1:10442856 C/T cg19773385 chr1:10388646 KIF1B -0.52 -8.15 -0.41 7.77e-15 Hepatocellular carcinoma; CRC cis rs2952156 0.920 rs2517951 chr17:37853097 C/T cg07936489 chr17:37558343 FBXL20 -0.44 -6.28 -0.33 1.06e-9 Asthma; CRC cis rs7786808 0.782 rs7787923 chr7:158227312 A/G cg09998033 chr7:158218633 PTPRN2 -0.63 -9.81 -0.48 4.19e-20 Obesity-related traits; CRC cis rs35110281 0.591 rs86139 chr21:44932802 G/A cg04455712 chr21:45112962 RRP1B 0.38 7.3 0.37 2.23e-12 Mean corpuscular volume; CRC cis rs7786808 0.741 rs62479982 chr7:158227546 A/G cg01191920 chr7:158217561 PTPRN2 -0.9 -17.38 -0.69 1.92e-48 Obesity-related traits; CRC cis rs977987 0.806 rs7185640 chr16:75394399 A/G cg03315344 chr16:75512273 CHST6 0.53 8.89 0.44 4.14e-17 Dupuytren's disease; CRC cis rs7927771 1.000 rs11039390 chr11:47796295 C/G cg05585544 chr11:47624801 NA -0.62 -10.82 -0.51 1.47e-23 Subjective well-being; CRC cis rs9906695 0.656 rs3138034 chr17:32642725 C/T cg12698626 chr17:32581466 CCL2 0.43 5.75 0.3 2.08e-8 Monocyte percentage of white cells; CRC cis rs881375 0.967 rs1548783 chr9:123658639 A/G cg09419670 chr9:123605666 PSMD5;LOC253039 0.51 6.78 0.35 5.68e-11 Rheumatoid arthritis; CRC cis rs853679 0.599 rs149949 chr6:28011516 T/C cg15786705 chr6:28176104 NA 0.67 6.48 0.34 3.27e-10 Depression; CRC cis rs7493 0.755 rs17883791 chr7:94999438 G/A cg21856205 chr7:94953877 PON1 -0.45 -5.81 -0.31 1.47e-8 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs10779751 0.922 rs11121708 chr1:11307253 G/C cg08854313 chr1:11322531 MTOR 0.68 9.63 0.47 1.72e-19 Body mass index; CRC cis rs2249694 0.520 rs10776685 chr10:135327317 T/C cg20169779 chr10:135381914 SYCE1 -0.53 -7.39 -0.38 1.23e-12 Obesity-related traits; CRC cis rs57590327 0.503 rs12638997 chr3:81844912 A/G cg07356753 chr3:81810745 GBE1 -0.62 -8.56 -0.43 4.24e-16 Extraversion; CRC cis rs10791323 0.569 rs2156679 chr11:133742304 C/T cg06766960 chr11:133703094 NA -0.35 -6.44 -0.33 4.29e-10 Childhood ear infection; CRC cis rs10479542 0.784 rs7702303 chr5:178986436 G/A cg26516362 chr5:178986906 RUFY1 0.39 7.08 0.36 8.73e-12 Lung cancer; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg27556566 chr18:29671984 RNF138 0.46 6.64 0.34 1.29e-10 Response to antipsychotic treatment; CRC trans rs7944735 0.938 rs59185955 chr11:47961566 G/C cg15704280 chr7:45808275 SEPT13 0.55 6.28 0.33 1.05e-9 Intraocular pressure; CRC cis rs769267 0.930 rs1054284 chr19:19616953 T/G cg01262667 chr19:19385393 TM6SF2 0.36 5.86 0.31 1.11e-8 Tonsillectomy; CRC cis rs6088590 0.561 rs764597 chr20:33161225 C/T cg24642439 chr20:33292090 TP53INP2 0.38 6.59 0.34 1.79e-10 Coronary artery disease; CRC cis rs2481665 1.000 rs2481665 chr1:62594677 T/C cg18591186 chr1:62594603 INADL -0.57 -8.37 -0.42 1.62e-15 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs2762353 0.595 rs9467591 chr6:25742699 C/T cg15691649 chr6:25882328 NA -0.47 -6.18 -0.32 1.91e-9 Blood metabolite levels; CRC cis rs2380220 0.606 rs7754906 chr6:95992429 C/T cg15832292 chr6:96025679 MANEA 0.56 6.28 0.33 1.04e-9 Behavioural disinhibition (generation interaction); CRC trans rs61931739 0.517 rs10844727 chr12:34017435 C/T cg26384229 chr12:38710491 ALG10B 0.52 7.04 0.36 1.11e-11 Morning vs. evening chronotype; CRC cis rs9443645 0.507 rs9352633 chr6:79462623 C/G cg09184832 chr6:79620586 NA -0.34 -6.35 -0.33 6.99e-10 Intelligence (multi-trait analysis); CRC cis rs853679 0.542 rs2295594 chr6:28053097 G/A cg21251018 chr6:28226885 NKAPL 0.48 6.29 0.33 9.93e-10 Depression; CRC cis rs10857712 0.754 rs2297032 chr10:135234580 C/T cg17796960 chr10:135278976 LOC619207 -0.37 -5.65 -0.3 3.53e-8 Systemic lupus erythematosus; CRC trans rs4332037 0.539 rs11764590 chr7:2032803 C/T cg11693508 chr17:37793320 STARD3 0.63 7.34 0.38 1.73e-12 Bipolar disorder; CRC cis rs9486719 1.000 rs13202675 chr6:97028427 C/T cg18709589 chr6:96969512 KIAA0776 -0.52 -5.85 -0.31 1.21e-8 Migraine;Coronary artery disease; CRC cis rs12936587 0.811 rs12945496 chr17:17537197 G/C cg09796270 chr17:17721594 SREBF1 -0.4 -5.68 -0.3 2.97e-8 Hip circumference;Coronary artery disease or large artery stroke;Coronary heart disease;Coronary artery disease; CRC cis rs2032447 0.901 rs2213284 chr6:26031868 G/A cg12588279 chr6:26043732 HIST1H2BB 0.48 6.85 0.35 3.67e-11 Intelligence (multi-trait analysis); CRC cis rs965469 0.779 rs6051830 chr20:3373397 T/C cg25506879 chr20:3388711 C20orf194 -0.37 -5.76 -0.3 1.96e-8 IFN-related cytopenia; CRC cis rs8077889 1.000 rs2880329 chr17:41866168 T/A cg26893861 chr17:41843967 DUSP3 0.99 12.71 0.57 2.26e-30 Triglycerides; CRC cis rs870825 0.616 rs14969 chr4:185615764 C/A cg04058563 chr4:185651563 MLF1IP 0.72 9.2 0.45 4.12e-18 Blood protein levels; CRC trans rs2303319 0.504 rs12470830 chr2:162429996 C/T cg12500891 chr11:57225987 NA -0.69 -6.06 -0.32 3.82e-9 Cognitive function; CRC cis rs12701220 0.553 rs7782024 chr7:1157502 G/T cg26240231 chr7:1148101 C7orf50 -0.44 -6.34 -0.33 7.6e-10 Bronchopulmonary dysplasia; CRC cis rs7312933 0.898 rs10880221 chr12:42384589 C/A cg11827402 chr12:42719852 PPHLN1;ZCRB1 0.57 7.49 0.38 6.27e-13 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CRC cis rs3858526 0.959 rs61876224 chr11:5952859 G/A cg05234568 chr11:5960015 NA -0.57 -7.91 -0.4 3.86e-14 DNA methylation (variation); CRC cis rs7493 0.950 rs7785705 chr7:95033803 A/T cg19678392 chr7:94953810 PON1 -0.6 -7.49 -0.38 6.21e-13 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs10751667 0.666 rs6597966 chr11:950750 T/C ch.11.42038R chr11:967971 AP2A2 0.57 9.77 0.47 5.75e-20 Alzheimer's disease (late onset); CRC cis rs3820068 0.581 rs72645861 chr1:15920314 A/G cg24675056 chr1:15929824 NA 0.47 6.29 0.33 1.01e-9 Systolic blood pressure; CRC cis rs17270561 0.609 rs4711094 chr6:25706174 T/A cg17691542 chr6:26056736 HIST1H1C 0.65 8.3 0.42 2.68e-15 Iron status biomarkers; CRC cis rs9992667 0.955 rs7654470 chr4:38636229 C/T cg19726192 chr4:38663646 FLJ13197 -0.67 -8.5 -0.42 6.48e-16 Eosinophil percentage of granulocytes; CRC cis rs873946 0.504 rs3829132 chr10:134579044 A/C cg26818010 chr10:134567672 INPP5A -0.6 -8.0 -0.4 2.09e-14 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CRC cis rs524281 0.773 rs4393319 chr11:66001878 A/T cg16950941 chr11:66035639 RAB1B -0.7 -8.04 -0.41 1.67e-14 Electroencephalogram traits; CRC cis rs34172651 0.517 rs2547040 chr16:24736408 G/C cg04756594 chr16:24857601 SLC5A11 -0.33 -6.82 -0.35 4.33e-11 Intelligence (multi-trait analysis); CRC cis rs7618915 0.571 rs34954168 chr3:52612159 C/T cg10802521 chr3:52805072 NEK4 -0.59 -9.16 -0.45 5.88e-18 Bipolar disorder; CRC cis rs250677 0.687 rs41181 chr5:148444257 C/G cg23229984 chr5:148520753 ABLIM3 -0.49 -6.74 -0.35 7.09e-11 Breast cancer; CRC cis rs9457247 0.555 rs2247325 chr6:167369992 A/G cg23791538 chr6:167370224 RNASET2 0.51 8.16 0.41 7.42e-15 Crohn's disease; CRC cis rs17213078 0.647 rs17279736 chr2:106757365 C/G cg16099169 chr2:106886729 NA 0.37 5.7 0.3 2.69e-8 Facial morphology (factor 23); CRC cis rs227584 0.663 rs3180912 chr17:42259463 A/G cg19774624 chr17:42201019 HDAC5 -0.6 -9.27 -0.46 2.53e-18 Bone mineral density (hip);Bone mineral density; CRC cis rs7772486 0.686 rs7744014 chr6:146123818 G/A cg23711669 chr6:146136114 FBXO30 0.7 11.88 0.55 2.47e-27 Lobe attachment (rater-scored or self-reported); CRC cis rs9914988 0.832 rs12946132 chr17:27157362 T/C cg16670446 chr17:27188758 MIR451;MIR144 0.53 8.4 0.42 1.32e-15 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs651907 0.557 rs3864012 chr3:101397623 T/C cg12386194 chr3:101231763 SENP7 0.47 6.78 0.35 5.53e-11 Colorectal cancer; CRC cis rs9902453 0.874 rs7213517 chr17:28401740 A/G cg26525008 chr17:28256777 EFCAB5;SSH2 -0.69 -11.43 -0.53 1.03e-25 Coffee consumption (cups per day); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg01397469 chr7:101458433 CUX1 0.5 6.84 0.35 3.97e-11 Response to antipsychotic treatment; CRC cis rs1799949 1.000 rs72829113 chr17:41181835 C/T cg05368731 chr17:41323189 NBR1 0.69 10.07 0.49 5.76e-21 Menopause (age at onset); CRC cis rs10504229 0.683 rs55645894 chr8:58116145 A/G cg02725872 chr8:58115012 NA -0.64 -11.55 -0.54 3.85e-26 Developmental language disorder (linguistic errors); CRC cis rs7927771 1.000 rs7105282 chr11:47805614 C/A cg20307385 chr11:47447363 PSMC3 -0.5 -6.58 -0.34 1.83e-10 Subjective well-being; CRC cis rs898097 0.845 rs7213006 chr17:80899928 T/C cg15664640 chr17:80829946 TBCD 0.55 8.83 0.44 6.42e-17 Breast cancer; CRC cis rs8067545 1.000 rs34291370 chr17:19942335 G/A cg13482628 chr17:19912719 NA 0.52 8.09 0.41 1.15e-14 Schizophrenia; CRC cis rs7512552 0.839 rs11581351 chr1:150440200 G/C cg15654264 chr1:150340011 RPRD2 0.58 8.22 0.41 4.63e-15 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); CRC cis rs35306767 0.855 rs2050944 chr10:918910 T/C cg26597838 chr10:835615 NA 0.98 12.08 0.55 4.57e-28 Eosinophil percentage of granulocytes; CRC cis rs9467773 0.967 rs9295694 chr6:26512994 A/T cg09904177 chr6:26538194 HMGN4 0.86 14.68 0.63 7.08e-38 Intelligence (multi-trait analysis); CRC cis rs798554 0.634 rs6970963 chr7:2821271 C/T cg19717773 chr7:2847554 GNA12 -0.43 -7.26 -0.37 2.79e-12 Height; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg11164639 chr15:91192950 NA 0.36 6.09 0.32 3.13e-9 Liver disease severity in Alagille syndrome; CRC cis rs17641971 0.708 rs2137013 chr8:49981091 C/T cg00325661 chr8:49890786 NA 0.37 6.41 0.33 5.09e-10 Blood metabolite levels; CRC cis rs8044868 0.530 rs12446480 chr16:72056757 A/G cg23815491 chr16:72088622 HP 0.47 6.84 0.35 3.85e-11 Body mass index (change over time) in cancer or chronic obstructive pulmonary disease;Body mass index (change over time) in cancer; CRC trans rs10842750 1.000 rs10842750 chr12:26690565 G/T cg21858291 chr2:237994312 COPS8 0.52 6.11 0.32 2.89e-9 Kashin-Beck disease; CRC cis rs4750440 0.585 rs4748069 chr10:14031188 A/G cg00551146 chr10:14014579 FRMD4A 0.44 6.98 0.36 1.6e-11 Adiponectin levels; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg25374230 chr6:37225404 TMEM217;TBC1D22B 0.39 6.32 0.33 8.31e-10 Liver disease severity in Alagille syndrome; CRC cis rs10504229 1.000 rs66477954 chr8:58187810 C/T cg02290350 chr8:58132656 NA -0.42 -5.96 -0.31 6.62e-9 Developmental language disorder (linguistic errors); CRC cis rs57590327 0.555 rs3772909 chr3:81707264 T/C cg07356753 chr3:81810745 GBE1 -0.63 -8.26 -0.41 3.51e-15 Extraversion; CRC cis rs7772486 0.790 rs2253764 chr6:146199881 T/A cg23711669 chr6:146136114 FBXO30 0.67 11.48 0.53 7.08e-26 Lobe attachment (rater-scored or self-reported); CRC cis rs13191362 1.000 rs13192894 chr6:163052444 T/A cg06582575 chr6:163149167 PACRG;PARK2 0.92 11.54 0.54 4.15e-26 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs9389248 0.690 rs728030 chr6:135246294 G/T cg22676075 chr6:135203613 NA -0.65 -10.39 -0.5 4.64e-22 High light scatter reticulocyte percentage of red cells; CRC cis rs2019137 0.967 rs902695 chr2:113955074 G/A cg21610815 chr2:113994035 PAX8;LOC654433;LOC440839 -0.45 -6.27 -0.33 1.11e-9 Lymphocyte counts; CRC cis rs2836974 0.897 rs13047678 chr21:40708853 C/T cg11644478 chr21:40555479 PSMG1 0.66 9.21 0.45 4.04e-18 Cognitive function; CRC cis rs6674970 1.000 rs4970941 chr1:151068546 A/G cg11822372 chr1:151115635 SEMA6C 0.53 7.59 0.39 3.39e-13 Childhood ear infection; CRC cis rs17234274 0.622 rs35342540 chr11:23238532 A/G cg05245346 chr11:23248277 NA 0.36 5.88 0.31 1.03e-8 Cancer; CRC cis rs17376456 0.877 rs10050465 chr5:93349963 C/A cg21475434 chr5:93447410 FAM172A 0.79 7.93 0.4 3.39e-14 Diabetic retinopathy; CRC cis rs3087591 0.960 rs2905880 chr17:29546175 A/G cg24425628 chr17:29625626 OMG;NF1 0.87 16.73 0.68 7.04e-46 Hip circumference; CRC cis rs523522 0.962 rs9788155 chr12:120938408 G/A cg12219531 chr12:120966889 COQ5 0.69 9.31 0.46 1.85e-18 High light scatter reticulocyte count; CRC trans rs3806843 0.864 rs2531343 chr5:140129346 A/G cg06840491 chr10:48416966 GDF2 -0.35 -6.04 -0.32 4.16e-9 Depressive symptoms (multi-trait analysis); CRC cis rs2204008 0.744 rs11514073 chr12:38399553 A/C cg13010199 chr12:38710504 ALG10B 0.45 5.72 0.3 2.42e-8 Bladder cancer; CRC trans rs11098499 0.754 rs2036857 chr4:120249240 T/C cg25214090 chr10:38739885 LOC399744 0.53 8.34 0.42 2e-15 Corneal astigmatism; CRC cis rs1552244 0.882 rs67762674 chr3:10014485 C/T cg08888203 chr3:10149979 C3orf24 0.64 8.57 0.43 4.03e-16 Alzheimer's disease; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg18513200 chr4:13629548 BOD1L 0.38 6.18 0.32 1.94e-9 Liver disease severity in Alagille syndrome; CRC cis rs2549003 0.811 rs10072700 chr5:131816903 A/C cg02551604 chr5:131831745 NA -0.52 -6.55 -0.34 2.22e-10 Asthma (sex interaction); CRC cis rs6938 0.534 rs1133322 chr15:75212357 A/G cg14664628 chr15:75095509 CSK -0.63 -9.85 -0.48 3.18e-20 Breast cancer; CRC cis rs2380220 0.606 rs7747776 chr6:96005852 C/T cg15832292 chr6:96025679 MANEA 0.59 7.16 0.37 5.43e-12 Behavioural disinhibition (generation interaction); CRC cis rs1707322 0.752 rs12027622 chr1:46130252 A/C cg06784218 chr1:46089804 CCDC17 0.65 12.18 0.56 2e-28 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs3020333 0.875 rs3020334 chr6:152012956 A/G cg22157087 chr6:152012887 ESR1 0.54 8.18 0.41 6.06e-15 Total body bone mineral density; CRC trans rs3942852 0.568 rs4412719 chr11:48101660 T/A cg15704280 chr7:45808275 SEPT13 -0.68 -9.6 -0.47 2.05e-19 Acute lymphoblastic leukemia (childhood); CRC cis rs6570726 0.902 rs9390326 chr6:145791222 A/G cg05347473 chr6:146136440 FBXO30 -0.37 -5.85 -0.31 1.18e-8 Lobe attachment (rater-scored or self-reported); CRC cis rs11764590 0.694 rs4721321 chr7:2068470 A/G cg23422044 chr7:1970798 MAD1L1 -0.41 -5.7 -0.3 2.72e-8 Neuroticism; CRC cis rs7591163 1.000 rs940341 chr2:228724726 A/G cg23807890 chr2:228736357 WDR69 -0.47 -6.54 -0.34 2.41e-10 Blood pressure; CRC cis rs2011503 1.000 rs75453386 chr19:19637781 C/T cg11584989 chr19:19387371 SF4 0.58 6.48 0.34 3.27e-10 Bipolar disorder; CRC cis rs8031584 0.958 rs7176569 chr15:31244495 G/T cg08109568 chr15:31115862 NA 0.52 8.39 0.42 1.41e-15 Huntington's disease progression; CRC cis rs9322193 0.884 rs10872648 chr6:150079835 A/G cg05861140 chr6:150128134 PCMT1 -0.42 -6.48 -0.34 3.31e-10 Lung cancer; CRC cis rs9902453 0.874 rs4474741 chr17:28148117 A/G cg26525008 chr17:28256777 EFCAB5;SSH2 -0.59 -8.99 -0.44 2.05e-17 Coffee consumption (cups per day); CRC cis rs904251 0.523 rs1757191 chr6:37482871 C/T cg01843034 chr6:37503916 NA -0.43 -8.08 -0.41 1.21e-14 Cognitive performance; CRC trans rs6678914 1.000 rs10920365 chr1:202189711 A/G cg19977628 chr5:1262072 TERT 0.4 5.98 0.31 5.83e-9 Breast cancer (estrogen-receptor negative);Breast cancer; CRC cis rs6062509 0.965 rs6062504 chr20:62348907 A/G cg01176363 chr20:62369445 LIME1 -0.41 -5.63 -0.3 3.92e-8 Prostate cancer; CRC trans rs853679 0.546 rs200954 chr6:27838764 C/G cg06606381 chr12:133084897 FBRSL1 -0.77 -6.6 -0.34 1.66e-10 Depression; CRC cis rs6582630 0.519 rs1607868 chr12:38385512 G/T cg26384229 chr12:38710491 ALG10B 0.69 9.8 0.48 4.63e-20 Drug-induced liver injury (flucloxacillin); CRC cis rs6500602 0.623 rs9929311 chr16:4510426 T/C cg14951292 chr16:4525986 HMOX2;NMRAL1 0.77 10.97 0.52 4.67e-24 Schizophrenia; CRC cis rs294883 0.858 rs9457582 chr6:159722081 G/A cg14500486 chr6:159655392 FNDC1 -0.35 -5.76 -0.3 1.95e-8 Coronary artery disease; CRC cis rs7927592 0.717 rs7126451 chr11:68257386 A/G cg16797656 chr11:68205561 LRP5 -0.47 -8.64 -0.43 2.51e-16 Total body bone mineral density; CRC cis rs295140 0.605 rs10931893 chr2:201114652 A/G cg23649088 chr2:200775458 C2orf69 -0.41 -5.81 -0.3 1.48e-8 QT interval; CRC cis rs9311474 0.508 rs2878628 chr3:52584715 C/T cg14092988 chr3:52407081 DNAH1 -0.3 -5.71 -0.3 2.55e-8 Electroencephalogram traits; CRC cis rs763121 0.853 rs11704021 chr22:39074716 G/A cg06544989 chr22:39130855 UNC84B 0.46 7.04 0.36 1.09e-11 Menopause (age at onset); CRC cis rs2806561 0.664 rs55764475 chr1:23318983 C/T cg12483005 chr1:23474871 LUZP1 0.44 6.33 0.33 7.86e-10 Height; CRC cis rs9916302 0.851 rs4390625 chr17:37620347 A/G cg07936489 chr17:37558343 FBXL20 -0.84 -13.1 -0.59 7.38e-32 Glomerular filtration rate (creatinine); CRC cis rs10504229 1.000 rs58053450 chr8:58173348 T/C cg02725872 chr8:58115012 NA -0.38 -6.43 -0.33 4.44e-10 Developmental language disorder (linguistic errors); CRC cis rs10463316 0.855 rs13359064 chr5:150765575 G/A cg03212797 chr5:150827313 SLC36A1 -0.49 -7.7 -0.39 1.6e-13 Metabolite levels (Pyroglutamine); CRC cis rs1552244 1.000 rs9824585 chr3:10114802 T/C cg08888203 chr3:10149979 C3orf24 0.7 9.84 0.48 3.31e-20 Alzheimer's disease; CRC cis rs28386778 0.863 rs6919 chr17:61909485 A/T cg06601766 chr17:61851465 DDX42;CCDC47 -0.42 -5.72 -0.3 2.34e-8 Prudent dietary pattern; CRC cis rs763121 0.719 rs9610995 chr22:39057763 C/T cg06544989 chr22:39130855 UNC84B 0.44 6.8 0.35 4.85e-11 Menopause (age at onset); CRC cis rs116095464 0.558 rs62344300 chr5:246336 A/G cg22496380 chr5:211416 CCDC127 -0.91 -10.41 -0.5 4.13e-22 Breast cancer; CRC cis rs4713118 0.869 rs9461401 chr6:27703291 G/A cg12172441 chr6:28176163 NA 0.52 7.19 0.37 4.51e-12 Parkinson's disease; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg04578738 chr17:34136331 TAF15 0.5 7.29 0.37 2.27e-12 Response to antipsychotic treatment; CRC cis rs4664293 0.647 rs918969 chr2:160466656 C/T cg08347373 chr2:160653686 CD302 0.39 6.6 0.34 1.67e-10 Monocyte percentage of white cells; CRC cis rs1552244 0.882 rs3732966 chr3:10015740 C/T cg00166722 chr3:10149974 C3orf24 0.61 7.92 0.4 3.81e-14 Alzheimer's disease; CRC cis rs4713118 0.824 rs9468223 chr6:27740666 C/T cg06470822 chr6:28175283 NA 0.77 10.33 0.49 7.34e-22 Parkinson's disease; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg21629349 chr11:60691880 TMEM132A 0.39 6.54 0.34 2.4e-10 Liver disease severity in Alagille syndrome; CRC cis rs4233802 1.000 rs6761697 chr2:151141735 A/G cg25300694 chr2:151184358 NA 0.91 7.25 0.37 2.96e-12 Plasma omega-3 polyunsaturated fatty acid levels (docosahexaenoic acid); CRC trans rs360798 0.532 rs13013218 chr2:63011671 C/T cg05376469 chr2:102649931 NA 0.38 6.11 0.32 2.86e-9 Coronary artery disease; CRC cis rs4964805 0.802 rs934847 chr12:104185693 C/T cg02344784 chr12:104178138 NT5DC3 0.57 8.92 0.44 3.3e-17 Attention deficit hyperactivity disorder; CRC cis rs12451471 0.637 rs12452616 chr17:78090081 A/G cg18972013 chr17:78078605 GAA 0.41 6.11 0.32 2.75e-9 Plateletcrit;Mean corpuscular hemoglobin concentration; CRC cis rs2282802 0.660 rs4463213 chr5:139545748 G/A cg26211634 chr5:139558579 C5orf32 -0.41 -7.06 -0.36 9.65e-12 Intelligence (multi-trait analysis); CRC trans rs3780486 0.874 rs10813955 chr9:33141791 C/T cg20290983 chr6:43655470 MRPS18A 1.17 25.32 0.81 3.06e-79 IgG glycosylation; CRC cis rs2204008 0.754 rs11181244 chr12:38302454 T/C cg13010199 chr12:38710504 ALG10B 0.47 6.29 0.33 1.01e-9 Bladder cancer; CRC cis rs2692947 0.770 rs12471925 chr2:96555522 C/A cg23100626 chr2:96804247 ASTL 0.27 7.02 0.36 1.26e-11 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg09428623 chr2:68480128 PPP3R1 0.45 6.3 0.33 9.42e-10 Response to antipsychotic treatment; CRC cis rs1799949 0.931 rs9912203 chr17:41445145 A/G cg23758822 chr17:41437982 NA -0.85 -15.99 -0.66 5.7e-43 Menopause (age at onset); CRC cis rs8077889 0.917 rs1859048 chr17:41892039 A/C cg16892393 chr17:41919603 NA -0.48 -7.27 -0.37 2.64e-12 Triglycerides; CRC cis rs9926296 0.568 rs886950 chr16:89836872 T/C cg04287289 chr16:89883240 FANCA 0.82 14.76 0.63 3.5e-38 Vitiligo; CRC cis rs6502050 0.835 rs11077981 chr17:80147243 C/T cg25804541 chr17:80189381 SLC16A3 -0.31 -5.9 -0.31 8.81e-9 Life satisfaction; CRC trans rs9650657 0.655 rs1991651 chr8:10706411 C/G cg06636001 chr8:8085503 FLJ10661 0.47 6.48 0.34 3.28e-10 Neuroticism; CRC cis rs7607369 0.718 rs6727147 chr2:219639024 G/A cg02176678 chr2:219576539 TTLL4 -0.41 -6.6 -0.34 1.62e-10 Red blood cell count;Amyotrophic lateral sclerosis; CRC cis rs951366 0.789 rs823110 chr1:205701078 G/C cg24503407 chr1:205819492 PM20D1 0.82 12.64 0.57 4.02e-30 Menarche (age at onset); CRC cis rs28374715 0.681 rs7168307 chr15:41620534 A/G cg18705301 chr15:41695430 NDUFAF1 -0.85 -14.44 -0.62 5.75e-37 Ulcerative colitis; CRC cis rs853679 0.517 rs9368552 chr6:28068426 A/G cg15845792 chr6:28175446 NA 0.99 13.1 0.59 7.48e-32 Depression; CRC cis rs11874712 0.527 rs7359798 chr18:43648999 A/C cg26436583 chr18:43649176 PSTPIP2 0.36 5.79 0.3 1.68e-8 Migraine - clinic-based; CRC cis rs9443645 0.901 rs9448580 chr6:79551812 C/G cg11833968 chr6:79620685 NA -0.35 -6.15 -0.32 2.2e-9 Intelligence (multi-trait analysis); CRC cis rs728616 0.867 rs7893241 chr10:81954338 C/T cg11900509 chr10:81946545 ANXA11 -0.76 -7.66 -0.39 2.1e-13 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs4654899 0.897 rs611658 chr1:21089133 T/G cg02927042 chr1:21476669 EIF4G3 -0.42 -6.63 -0.34 1.34e-10 Superior frontal gyrus grey matter volume; CRC cis rs9354352 0.784 rs2062327 chr6:66689923 C/G cg07460842 chr6:66804631 NA -0.64 -9.51 -0.46 4.16e-19 Initial pursuit acceleration in psychotic disorders; CRC cis rs10504229 0.953 rs116564484 chr8:58172818 T/C cg22535103 chr8:58192502 C8orf71 -0.79 -12.09 -0.55 4.31e-28 Developmental language disorder (linguistic errors); CRC cis rs4728142 0.604 rs6467222 chr7:128674419 T/C cg06630958 chr7:128577819 IRF5 -0.35 -5.74 -0.3 2.14e-8 Inflammatory bowel disease;Systemic lupus erythematosus;Ulcerative colitis; CRC cis rs10189230 0.967 rs13012331 chr2:222350600 G/A cg14652038 chr2:222343519 EPHA4 0.52 10.01 0.48 8.96e-21 Urate levels in lean individuals; CRC cis rs6942756 0.531 rs9649530 chr7:128927406 G/A cg02491457 chr7:128862824 NA 0.54 7.75 0.39 1.14e-13 White matter hyperintensity burden; CRC cis rs8077889 0.917 rs72836553 chr17:41909851 A/G cg16892393 chr17:41919603 NA 0.6 8.63 0.43 2.61e-16 Triglycerides; CRC cis rs4713118 0.513 rs156739 chr6:28013410 C/A cg02683197 chr6:28174875 NA 0.61 8.31 0.42 2.52e-15 Parkinson's disease; CRC cis rs9309711 0.560 rs6548164 chr2:3472665 C/T cg15506890 chr2:3487001 NA 0.42 6.55 0.34 2.19e-10 Neurofibrillary tangles; CRC cis rs9916302 0.653 rs11654954 chr17:37745979 C/T cg20243544 chr17:37824526 PNMT -0.49 -6.28 -0.33 1.06e-9 Glomerular filtration rate (creatinine); CRC cis rs2019137 0.539 rs11123170 chr2:113978940 C/G cg11763394 chr2:113992921 PAX8;LOC440839;LOC654433 0.69 10.43 0.5 3.35e-22 Lymphocyte counts; CRC cis rs7172809 0.643 rs80347838 chr15:77841783 A/G cg10437265 chr15:77819839 NA -0.35 -5.86 -0.31 1.13e-8 Glucose homeostasis traits; CRC cis rs950776 0.616 rs6495307 chr15:78890321 C/T cg06917634 chr15:78832804 PSMA4 0.52 8.01 0.4 2.07e-14 Sudden cardiac arrest; CRC cis rs4481887 1.000 rs10736378 chr1:248455769 T/G cg13385794 chr1:248469461 NA 0.38 6.69 0.35 9.77e-11 Common traits (Other); CRC cis rs6585424 1.000 rs12411386 chr10:81926231 T/A cg11900509 chr10:81946545 ANXA11 -0.76 -9.32 -0.46 1.78e-18 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs4750440 0.637 rs2447010 chr10:14032115 T/C cg04819048 chr10:14014548 FRMD4A 0.37 6.11 0.32 2.89e-9 Adiponectin levels; CRC cis rs12477438 0.520 rs11883676 chr2:99800814 G/T cg14399236 chr2:99771627 LIPT1;TSGA10 0.81 14.32 0.62 1.66e-36 Chronic sinus infection; CRC cis rs6951245 0.744 rs1133122 chr7:1192572 C/A cg03188948 chr7:1209495 NA 0.7 7.84 0.4 6.18e-14 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs7666738 0.893 rs11729640 chr4:99052699 C/T cg17366294 chr4:99064904 C4orf37 0.45 7.75 0.39 1.16e-13 Colonoscopy-negative controls vs population controls; CRC trans rs7937682 0.924 rs875258 chr11:111530607 C/A cg18187862 chr3:45730750 SACM1L 0.47 6.82 0.35 4.38e-11 Primary sclerosing cholangitis; CRC cis rs7224685 0.501 rs781850 chr17:3957124 C/T cg05562828 chr17:3906858 NA -0.65 -11.66 -0.54 1.51e-26 Type 2 diabetes; CRC cis rs9486715 1.000 rs6902835 chr6:97063005 C/G cg06623918 chr6:96969491 KIAA0776 -0.96 -16.68 -0.68 1.1e-45 Headache; CRC cis rs514406 0.607 rs11206000 chr1:53205923 A/C cg25767906 chr1:53392781 SCP2 0.37 5.86 0.31 1.13e-8 Monocyte count; CRC trans rs2228479 0.850 rs17226428 chr16:89842884 T/A cg21302420 chr1:112162376 RAP1A 0.72 5.96 0.31 6.33e-9 Skin colour saturation; CRC cis rs9649213 0.593 rs6970990 chr7:97925382 T/G cg24562669 chr7:97807699 LMTK2 0.44 7.28 0.37 2.53e-12 Prostate cancer (SNP x SNP interaction); CRC cis rs853679 0.517 rs3823180 chr6:28061744 G/A cg12172441 chr6:28176163 NA 0.62 7.38 0.38 1.28e-12 Depression; CRC cis rs875971 0.522 rs4718286 chr7:65292764 A/G cg18912574 chr7:65842487 NCRNA00174 0.33 5.64 0.3 3.58e-8 Aortic root size; CRC cis rs10193935 1.000 rs62144748 chr2:42419468 C/T cg27598129 chr2:42591480 NA -0.68 -7.82 -0.4 7.11e-14 Colonoscopy-negative controls vs population controls; CRC cis rs10779751 0.770 rs11121695 chr1:11229515 G/A cg08854313 chr1:11322531 MTOR -0.61 -7.6 -0.39 3.07e-13 Body mass index; CRC cis rs763121 0.853 rs3747174 chr22:39069181 T/C cg06022373 chr22:39101656 GTPBP1 0.8 12.62 0.57 4.84e-30 Menopause (age at onset); CRC cis rs3736485 0.903 rs4545756 chr15:51877790 A/G cg08986416 chr15:51914746 DMXL2 -0.46 -6.56 -0.34 2.11e-10 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs2463822 1.000 rs2463825 chr11:62094493 G/A cg06239285 chr11:62104954 ASRGL1 0.96 11.34 0.53 2.22e-25 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs17065868 1.000 rs9525985 chr13:45167390 C/G cg10246903 chr13:45222710 NA 0.53 5.95 0.31 6.84e-9 Antineutrophil cytoplasmic antibody-associated vasculitis; CRC cis rs6912958 0.559 rs445434 chr6:88041849 A/G cg04972856 chr6:88032051 C6orf162;GJB7 0.35 6.43 0.33 4.58e-10 Monocyte percentage of white cells; CRC cis rs4728302 0.869 rs13228262 chr7:133598288 A/G cg03336402 chr7:133662267 EXOC4 -0.45 -6.5 -0.34 2.97e-10 Intelligence;Intelligence (multi-trait analysis); CRC cis rs1707322 1.000 rs4660335 chr1:46474718 C/T cg06784218 chr1:46089804 CCDC17 0.6 10.68 0.51 4.65e-23 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs832540 0.931 rs702679 chr5:56221328 A/G cg12311346 chr5:56204834 C5orf35 -0.52 -8.06 -0.41 1.46e-14 Coronary artery disease; CRC trans rs7726839 0.794 rs10474792 chr5:600058 G/A cg25482853 chr8:67687455 SGK3 0.76 9.32 0.46 1.7e-18 Obesity-related traits; CRC cis rs1865760 0.964 rs9295677 chr6:25933712 T/C cg17691542 chr6:26056736 HIST1H1C 0.52 7.54 0.38 4.56e-13 Height; CRC cis rs7615952 0.512 rs11929125 chr3:125359443 G/A cg11143507 chr3:125485238 NA -0.58 -7.46 -0.38 7.69e-13 Blood pressure (smoking interaction); CRC cis rs9549260 0.755 rs59308928 chr13:41245079 C/T cg21288729 chr13:41239152 FOXO1 0.5 7.76 0.39 1.08e-13 Red blood cell count; CRC cis rs12900413 0.959 rs28430604 chr15:90313782 C/T cg24249390 chr15:90295951 MESP1 -0.6 -9.03 -0.45 1.51e-17 Coronary artery aneurysm in Kawasaki disease; CRC cis rs6076065 0.723 rs2224074 chr20:23360171 G/C cg11657817 chr20:23433608 CST11 0.47 6.85 0.35 3.74e-11 Facial morphology (factor 15, philtrum width); CRC trans rs498079 0.544 rs509904 chr6:133517082 A/T cg19727641 chr3:138067606 MRAS -0.51 -6.27 -0.33 1.14e-9 Total body bone mineral density; CRC cis rs10256972 0.616 rs4585652 chr7:1145396 A/G cg26608667 chr7:1196370 ZFAND2A 0.39 6.11 0.32 2.76e-9 Longevity;Endometriosis; CRC cis rs2456568 0.805 rs55649862 chr11:93682888 G/T cg26875233 chr11:93583750 C11orf90 -0.34 -6.71 -0.35 8.58e-11 Response to serotonin reuptake inhibitors in major depressive disorder; CRC cis rs798554 0.634 rs6970963 chr7:2821271 C/T cg17321639 chr7:2759063 NA -0.38 -5.74 -0.3 2.16e-8 Height; CRC cis rs4073582 0.595 rs708471 chr11:65931008 A/G cg16950941 chr11:66035639 RAB1B 0.71 12.29 0.56 8.27e-29 Gout; CRC cis rs763014 0.932 rs2384972 chr16:674424 G/A cg18653534 chr16:772142 FAM173A -0.37 -5.89 -0.31 9.6e-9 Height; CRC cis rs780096 0.587 rs10205219 chr2:27568565 T/C cg02592271 chr2:27665507 KRTCAP3 -0.27 -6.11 -0.32 2.85e-9 Total body bone mineral density; CRC cis rs6502050 0.865 rs74480314 chr17:80117716 C/T cg19223190 chr17:80058835 NA 0.38 6.17 0.32 2e-9 Life satisfaction; CRC cis rs2976388 1.000 rs1045547 chr8:143763757 T/G cg04969067 chr8:143858791 LYNX1 -0.35 -5.92 -0.31 8.2e-9 Urinary tract infection frequency; CRC cis rs6570726 0.967 rs373704 chr6:145860618 C/A cg23711669 chr6:146136114 FBXO30 0.72 12.59 0.57 6.15e-30 Lobe attachment (rater-scored or self-reported); CRC cis rs7089973 0.836 rs7895551 chr10:116625481 C/T cg23260525 chr10:116636907 FAM160B1 0.31 6.75 0.35 6.66e-11 Bipolar disorder or attention deficit hyperactivity disorder; CRC cis rs3018066 0.666 rs10084928 chr4:107050979 T/C cg01869342 chr4:106983673 TBCK 0.44 5.79 0.3 1.69e-8 Cancer; CRC cis rs7605827 0.930 rs3805105 chr2:15535312 T/A cg19274914 chr2:15703543 NA 0.39 5.88 0.31 9.87e-9 Educational attainment (years of education); CRC cis rs4843747 0.636 rs11117358 chr16:88105053 T/A cg17633681 chr16:88106987 BANP 0.86 16.03 0.66 3.74e-43 Menopause (age at onset); CRC cis rs9486719 1.000 rs2472887 chr6:96865437 A/G cg06623918 chr6:96969491 KIAA0776 0.81 9.48 0.46 5.18e-19 Migraine;Coronary artery disease; CRC trans rs72991 0.639 rs10750187 chr11:121230225 A/G cg27192990 chr6:129479024 LAMA2 -0.42 -6.14 -0.32 2.44e-9 Response to tocilizumab in rheumatoid arthritis; CRC cis rs10089 0.857 rs7718286 chr5:127459414 G/C cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.72 9.97 0.48 1.28e-20 Ileal carcinoids; CRC cis rs2050392 0.630 rs303427 chr10:30739780 G/A cg18806716 chr10:30721971 MAP3K8 -0.49 -6.98 -0.36 1.65e-11 Inflammatory bowel disease; CRC cis rs892961 0.720 rs103458 chr17:75416031 A/G cg05865280 chr17:75406074 SEPT9 0.61 13.39 0.59 6.4e-33 Airflow obstruction; CRC cis rs9916302 0.851 rs11078906 chr17:37662767 C/T cg15445000 chr17:37608096 MED1 0.42 9.31 0.46 1.91e-18 Glomerular filtration rate (creatinine); CRC cis rs67340775 0.541 rs200968 chr6:27859568 T/C cg12273811 chr6:28175739 NA 0.58 6.06 0.32 3.72e-9 Lung cancer in ever smokers; CRC cis rs7826238 0.535 rs2979179 chr8:8320029 C/T cg08975724 chr8:8085496 FLJ10661 0.42 6.65 0.34 1.19e-10 Systolic blood pressure; CRC cis rs4819052 0.851 rs8134392 chr21:46663790 A/G cg19498844 chr21:46707878 POFUT2;LOC642852 -0.78 -11.39 -0.53 1.43e-25 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs10504229 0.639 rs35527749 chr8:58128077 G/T cg20607798 chr8:58055168 NA 0.54 6.2 0.32 1.68e-9 Developmental language disorder (linguistic errors); CRC cis rs11758351 0.660 rs16891446 chr6:26226996 A/C cg01420254 chr6:26195488 NA 0.77 8.59 0.43 3.61e-16 Gout;Renal underexcretion gout; CRC cis rs10504229 1.000 rs9650139 chr8:58190508 G/T cg22535103 chr8:58192502 C8orf71 -0.81 -12.2 -0.56 1.72e-28 Developmental language disorder (linguistic errors); CRC cis rs1005277 0.579 rs2472178 chr10:38384750 T/C cg00409905 chr10:38381863 ZNF37A -0.66 -11.29 -0.53 3.37e-25 Extrinsic epigenetic age acceleration; CRC cis rs34779708 0.897 rs35784065 chr10:35353574 C/T cg03585969 chr10:35415529 CREM 0.65 8.64 0.43 2.46e-16 Inflammatory bowel disease;Crohn's disease; CRC cis rs2836974 0.831 rs34294410 chr21:40555160 C/G cg11644478 chr21:40555479 PSMG1 0.82 12.49 0.57 1.43e-29 Cognitive function; CRC cis rs7945705 0.692 rs2742470 chr11:9004002 C/T cg21881798 chr11:8931708 C11orf17;ST5 -0.65 -10.94 -0.52 5.99e-24 Hemoglobin concentration; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg08127348 chr19:17448311 GTPBP3 0.46 6.44 0.33 4.25e-10 Response to antipsychotic treatment; CRC cis rs10078 0.571 rs2671890 chr5:456457 A/G cg07599136 chr5:415885 AHRR 0.71 7.04 0.36 1.09e-11 Fat distribution (HIV); CRC cis rs12545109 0.765 rs1960727 chr8:57411368 G/A cg09654669 chr8:57350985 NA -0.4 -5.68 -0.3 2.99e-8 Obesity-related traits; CRC cis rs6831352 0.918 rs1042364 chr4:100045574 T/C cg13256891 chr4:100009986 ADH5 0.65 8.93 0.44 3.15e-17 Alcohol dependence; CRC cis rs10883723 0.668 rs12414407 chr10:104387019 A/G cg11453585 chr10:104263688 ACTR1A;SUFU -0.82 -13.73 -0.6 3.09e-34 Allergic disease (asthma, hay fever or eczema); CRC cis rs7666738 0.830 rs4401456 chr4:98959902 C/T cg17366294 chr4:99064904 C4orf37 0.43 7.34 0.38 1.69e-12 Colonoscopy-negative controls vs population controls; CRC trans rs1814175 0.645 rs2140602 chr11:50022800 G/C cg03929089 chr4:120376271 NA -0.88 -15.84 -0.66 2.09e-42 Height; CRC cis rs6502050 0.865 rs56193110 chr17:80151501 A/G cg25804541 chr17:80189381 SLC16A3 -0.3 -5.71 -0.3 2.56e-8 Life satisfaction; CRC cis rs1401999 1.000 rs3805108 chr3:183691650 T/C cg05044414 chr3:183734942 ABCC5 0.44 7.76 0.39 1.06e-13 Anterior chamber depth; CRC cis rs6714710 0.603 rs35505530 chr2:98506910 T/C cg26665480 chr2:98280029 ACTR1B 0.53 7.36 0.38 1.53e-12 Posterior cortical atrophy and Alzheimer's disease; CRC cis rs2991971 0.901 rs11211122 chr1:45954650 C/T cg15605315 chr1:45957053 TESK2 0.43 6.78 0.35 5.65e-11 High light scatter reticulocyte count; CRC cis rs4845875 0.626 rs4845882 chr1:11843167 A/G cg02448276 chr1:11845238 NA 0.36 5.65 0.3 3.47e-8 Midregional pro atrial natriuretic peptide levels; CRC cis rs7113874 0.524 rs10769925 chr11:8623585 C/T cg17679104 chr11:8615758 STK33 0.34 5.8 0.3 1.59e-8 Body mass index in physically active individuals;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs2257205 0.667 rs28605629 chr17:56906157 C/A cg25885038 chr17:56607967 SEPT4 -0.53 -5.85 -0.31 1.2e-8 Pancreatic cancer; CRC cis rs7615952 0.641 rs60839048 chr3:125807938 G/A cg04553112 chr3:125709451 NA -0.53 -6.09 -0.32 3.2e-9 Blood pressure (smoking interaction); CRC cis rs9916302 0.706 rs6503521 chr17:37715551 A/C cg07936489 chr17:37558343 FBXL20 0.83 9.42 0.46 8.22e-19 Glomerular filtration rate (creatinine); CRC cis rs10504229 0.815 rs17805008 chr8:58160185 G/T cg22535103 chr8:58192502 C8orf71 -0.69 -8.34 -0.42 2.05e-15 Developmental language disorder (linguistic errors); CRC cis rs1971762 0.583 rs10876485 chr12:54087648 C/T cg06632207 chr12:54070931 ATP5G2 -0.38 -6.57 -0.34 1.96e-10 Height; CRC trans rs1325598 0.935 rs1014719 chr1:176802766 G/T cg03992096 chr13:114928177 NA -0.38 -6.03 -0.32 4.51e-9 Height; CRC trans rs61931739 0.817 rs10743842 chr12:34306859 C/T cg26384229 chr12:38710491 ALG10B 0.44 6.39 0.33 5.75e-10 Morning vs. evening chronotype; CRC cis rs6545883 0.525 rs1621048 chr2:61364216 C/G cg10580144 chr2:61372316 C2orf74 -0.28 -5.66 -0.3 3.36e-8 Tuberculosis; CRC trans rs634534 0.561 rs14157 chr11:65769780 T/G cg17712092 chr4:129076599 LARP1B 0.68 11.33 0.53 2.39e-25 Sum eosinophil basophil counts;Eosinophil counts; CRC cis rs6499255 1.000 rs12596679 chr16:69822680 A/G cg15192750 chr16:69999425 NA -0.55 -7.27 -0.37 2.58e-12 IgE levels; CRC cis rs8072100 0.688 rs12602134 chr17:45582136 C/G cg25173405 chr17:45401733 C17orf57 0.48 7.61 0.39 2.96e-13 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs79349575 0.811 rs80032154 chr17:47014992 C/A cg00947319 chr17:47005597 UBE2Z -0.35 -5.88 -0.31 9.86e-9 Type 2 diabetes; CRC cis rs798554 0.796 rs2158694 chr7:2863443 T/G cg14895029 chr7:2775587 GNA12 -0.45 -6.49 -0.34 3.09e-10 Height; CRC cis rs9916302 0.752 rs8071300 chr17:37508524 G/C cg15445000 chr17:37608096 MED1 -0.35 -6.12 -0.32 2.59e-9 Glomerular filtration rate (creatinine); CRC cis rs6694672 0.867 rs571106 chr1:197256688 G/T cg13682187 chr1:196946512 CFHR5 0.5 7.05 0.36 1.05e-11 Asthma; CRC cis rs13392177 0.660 rs10932762 chr2:219076213 G/C cg04731861 chr2:219085781 ARPC2 0.32 6.33 0.33 7.9e-10 Pyoderma gangrenosum in inflammatory bowel disease; CRC cis rs9916302 0.752 rs6503513 chr17:37561613 A/G cg03013999 chr17:37608204 MED1 -0.45 -6.33 -0.33 8e-10 Glomerular filtration rate (creatinine); CRC cis rs28386778 0.863 rs9897229 chr17:61782325 T/C cg06873352 chr17:61820015 STRADA 0.73 12.82 0.58 8.55e-31 Prudent dietary pattern; CRC cis rs1008375 1.000 rs6848360 chr4:17634442 G/T cg02297831 chr4:17616191 MED28 0.48 6.44 0.33 4.31e-10 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs1881797 1.000 rs10925062 chr1:247658978 G/C cg11166453 chr1:247681781 NA 0.44 6.89 0.36 2.8e-11 Acute lymphoblastic leukemia (childhood); CRC trans rs2303319 0.504 rs1449641 chr2:162619567 T/C cg18122310 chr12:50236657 BCDIN3D -0.73 -6.35 -0.33 7.23e-10 Cognitive function; CRC cis rs10782582 0.593 rs6675076 chr1:76118503 A/C cg03433033 chr1:76189801 ACADM -0.45 -6.48 -0.34 3.32e-10 Daytime sleep phenotypes; CRC cis rs1348850 0.632 rs12471621 chr2:178502353 T/C cg02961200 chr2:178257176 LOC100130691;AGPS 0.62 8.74 0.43 1.22e-16 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs11098699 0.821 rs7665722 chr4:124201501 A/G cg09941581 chr4:124220074 SPATA5 0.41 6.05 0.32 3.91e-9 Mosquito bite size; CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg15008879 chr10:22292810 DNAJC1 -0.52 -6.45 -0.34 4.02e-10 Diisocyanate-induced asthma; CRC cis rs921968 0.613 rs556497 chr2:219446477 G/A cg02176678 chr2:219576539 TTLL4 0.48 8.02 0.4 1.82e-14 Mean corpuscular hemoglobin concentration; CRC cis rs863345 0.604 rs2873595 chr1:158508382 G/T cg12129480 chr1:158549410 OR10X1 -0.3 -6.27 -0.33 1.12e-9 Pneumococcal bacteremia; CRC cis rs344364 0.511 rs62040569 chr16:1948137 C/T cg09830162 chr16:1889614 FAHD1;C16orf73 -0.77 -9.36 -0.46 1.32e-18 Glomerular filtration rate in chronic kidney disease; CRC trans rs9354308 0.901 rs2814121 chr6:66566915 G/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.48 6.06 0.32 3.69e-9 Metabolite levels; CRC cis rs526821 0.595 rs485555 chr11:55323570 A/G cg04317927 chr11:55418816 OR4S2 -0.39 -6.67 -0.35 1.05e-10 Pediatric bone mineral density (spine); CRC cis rs711245 0.574 rs1179494 chr2:36809496 C/G cg09467607 chr2:36825704 FEZ2 -0.5 -8.15 -0.41 7.8e-15 Height; CRC cis rs10504229 0.906 rs114627636 chr8:58173732 C/T cg02290350 chr8:58132656 NA -0.52 -5.68 -0.3 2.89e-8 Developmental language disorder (linguistic errors); CRC cis rs9611565 0.729 rs12165508 chr22:41819960 T/C cg03806693 chr22:41940476 POLR3H 0.77 10.27 0.49 1.24e-21 Vitiligo; CRC cis rs1046896 1.000 rs9909940 chr17:80689036 C/T cg08200770 chr17:80723486 TBCD -0.41 -7.04 -0.36 1.09e-11 Glycated hemoglobin levels; CRC cis rs9443645 0.527 rs9352691 chr6:79785607 C/T cg09184832 chr6:79620586 NA -0.43 -7.27 -0.37 2.68e-12 Intelligence (multi-trait analysis); CRC cis rs6582630 0.502 rs11520276 chr12:38359216 C/T cg26384229 chr12:38710491 ALG10B 0.69 9.78 0.47 5.51e-20 Drug-induced liver injury (flucloxacillin); CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg24616553 chr3:113557638 GRAMD1C 0.38 6.17 0.32 2.06e-9 Obesity-related traits; CRC cis rs7726839 0.540 rs4957083 chr5:659343 T/C cg14541582 chr5:601475 NA -0.33 -6.59 -0.34 1.8e-10 Obesity-related traits; CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg03705947 chr1:68152081 GADD45A -0.54 -6.7 -0.35 9.2e-11 Diisocyanate-induced asthma; CRC cis rs13191362 0.872 rs13213421 chr6:163203805 A/G cg23758597 chr6:163146217 PARK2 -0.67 -6.96 -0.36 1.88e-11 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs2836950 0.840 rs12482317 chr21:40588241 A/G cg06238570 chr21:40685208 BRWD1 -0.46 -5.89 -0.31 9.5e-9 Menarche (age at onset); CRC cis rs9811920 0.809 rs793475 chr3:99543764 A/G cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G -0.41 -5.74 -0.3 2.1e-8 Axial length; CRC cis rs6445967 1.000 rs6445967 chr3:58282576 T/C cg23715586 chr3:58305044 RPP14 0.36 5.94 0.31 7.17e-9 Platelet count; CRC cis rs6831352 0.918 rs4699714 chr4:100060538 A/G cg13256891 chr4:100009986 ADH5 -0.66 -8.98 -0.44 2.17e-17 Alcohol dependence; CRC cis rs933688 1.000 rs2059207 chr5:90731931 C/A cg02339078 chr5:90679543 LOC100129716;ARRDC3 0.86 14.57 0.63 1.94e-37 Smoking behavior; CRC cis rs28386778 0.830 rs2584625 chr17:61903445 G/C cg11494091 chr17:61959527 GH2 0.63 10.64 0.51 6.32e-23 Prudent dietary pattern; CRC cis rs644799 0.965 rs11021305 chr11:95498269 A/G cg03916912 chr11:95522834 CEP57;FAM76B 0.94 16.83 0.68 2.65e-46 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs9894429 0.671 rs6565616 chr17:79612161 C/T cg21984481 chr17:79567631 NPLOC4 -0.43 -7.39 -0.38 1.24e-12 Eye color traits; CRC cis rs9814567 1.000 rs28409322 chr3:134252385 T/C cg06541857 chr3:134203789 ANAPC13;CEP63 0.39 5.74 0.3 2.15e-8 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC trans rs9929218 0.954 rs9928796 chr16:68820718 A/G cg04657470 chr2:198365150 HSPE1;HSPD1 -0.79 -10.93 -0.52 6.14e-24 Colorectal cancer; CRC cis rs12760731 0.920 rs12076608 chr1:178487861 C/G cg00404053 chr1:178313656 RASAL2 0.69 7.72 0.39 1.45e-13 Obesity-related traits; CRC cis rs12594515 0.967 rs11070466 chr15:45984955 C/T cg19682013 chr15:45996608 NA 0.35 7.17 0.37 5.09e-12 Waist circumference;Weight; CRC cis rs2153535 0.580 rs969422 chr6:8451780 A/T cg21535247 chr6:8435926 SLC35B3 0.5 7.45 0.38 8.15e-13 Motion sickness; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg13795627 chr1:157015873 ARHGEF11 -0.39 -6.14 -0.32 2.43e-9 Myopia (pathological); CRC cis rs11148252 0.538 rs2408609 chr13:52714043 C/T cg12458913 chr13:53173898 NA 0.46 6.77 0.35 5.99e-11 Lewy body disease; CRC trans rs1814175 0.791 rs10839468 chr11:49986288 A/G cg15704280 chr7:45808275 SEPT13 -0.97 -18.82 -0.72 3.98e-54 Height; CRC cis rs6424115 0.760 rs2999566 chr1:24051124 A/G cg10978503 chr1:24200527 CNR2 0.44 7.43 0.38 9.38e-13 Immature fraction of reticulocytes; CRC cis rs4862750 0.794 rs7672272 chr4:187896774 T/G cg07414643 chr4:187882934 NA 0.4 6.98 0.36 1.59e-11 Lobe attachment (rater-scored or self-reported); CRC cis rs889312 0.500 rs832566 chr5:56151744 C/T cg12311346 chr5:56204834 C5orf35 -0.45 -6.78 -0.35 5.5e-11 Breast cancer;Breast cancer (early onset); CRC cis rs950169 0.920 rs12915390 chr15:84792069 T/C cg17507749 chr15:85114479 UBE2QP1 0.76 11.88 0.55 2.53e-27 Schizophrenia; CRC cis rs9372498 0.536 rs2356501 chr6:118942371 C/A cg01339444 chr6:118972232 C6orf204 0.54 6.01 0.31 4.89e-9 Diastolic blood pressure; CRC cis rs17376456 0.877 rs9314095 chr5:93425495 T/C cg21475434 chr5:93447410 FAM172A 0.74 7.63 0.39 2.64e-13 Diabetic retinopathy; CRC cis rs6570726 0.577 rs867056 chr6:145784805 A/C cg13319975 chr6:146136371 FBXO30 0.6 8.7 0.43 1.67e-16 Lobe attachment (rater-scored or self-reported); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg25577272 chr5:54603267 SKIV2L2;DHX29 0.45 6.16 0.32 2.14e-9 Response to antipsychotic treatment; CRC cis rs17818399 0.708 rs13000706 chr2:46838247 C/G cg26688816 chr2:46740690 ATP6V1E2 -0.43 -6.52 -0.34 2.71e-10 Height; CRC cis rs470119 1.000 rs470119 chr22:50966914 C/T cg12969734 chr22:50962224 SCO2 -0.36 -5.78 -0.3 1.75e-8 Mean corpuscular hemoglobin; CRC cis rs7659604 0.539 rs11098645 chr4:122729251 G/A cg06713675 chr4:122721982 EXOSC9 -0.52 -8.32 -0.42 2.4e-15 Type 2 diabetes; CRC cis rs274567 0.550 rs272885 chr5:131667736 A/G cg11843238 chr5:131593191 PDLIM4 0.43 7.34 0.37 1.73e-12 Blood metabolite levels; CRC cis rs28386778 0.829 rs1877317 chr17:61776479 T/C cg22520471 chr17:61851767 DDX42;CCDC47 0.75 11.22 0.53 6e-25 Prudent dietary pattern; CRC cis rs875971 0.545 rs10950036 chr7:65818228 G/T cg03233332 chr7:66118400 NA -0.44 -6.21 -0.32 1.62e-9 Aortic root size; CRC cis rs524281 0.861 rs10896081 chr11:65880354 A/T cg16950941 chr11:66035639 RAB1B -0.59 -7.34 -0.37 1.72e-12 Electroencephalogram traits; CRC cis rs9322193 0.923 rs12176034 chr6:150121693 C/T cg13206674 chr6:150067644 NUP43 0.65 9.01 0.45 1.66e-17 Lung cancer; CRC cis rs6502050 0.835 rs12450189 chr17:80095128 A/C cg19223190 chr17:80058835 NA 0.4 6.36 0.33 6.88e-10 Life satisfaction; CRC cis rs7258465 1.000 rs28572537 chr19:18552208 C/T cg01065977 chr19:18549689 ISYNA1 -0.42 -6.37 -0.33 6.41e-10 Breast cancer; CRC cis rs34779708 0.966 rs35079558 chr10:35479886 A/G cg03585969 chr10:35415529 CREM 0.63 8.48 0.42 7.48e-16 Inflammatory bowel disease;Crohn's disease; CRC cis rs11608355 0.545 rs35590455 chr12:109893514 A/G cg05360138 chr12:110035743 NA 0.77 8.7 0.43 1.65e-16 Neuroticism; CRC cis rs9291683 0.632 rs11734786 chr4:10041499 A/C cg00071950 chr4:10020882 SLC2A9 0.67 12.66 0.57 3.38e-30 Bone mineral density; CRC cis rs6460942 0.591 rs6942551 chr7:12338356 C/T cg06484146 chr7:12443880 VWDE -0.6 -6.61 -0.34 1.57e-10 Coronary artery disease; CRC trans rs916888 0.821 rs199509 chr17:44858728 G/A cg01341218 chr17:43662625 NA -0.83 -9.39 -0.46 1.03e-18 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs12908161 0.959 rs34028043 chr15:85231585 G/A cg17507749 chr15:85114479 UBE2QP1 0.63 8.93 0.44 2.99e-17 Schizophrenia; CRC cis rs11249608 0.548 rs62393076 chr5:178450646 C/G cg01312482 chr5:178451176 ZNF879 -0.37 -6.13 -0.32 2.55e-9 Pubertal anthropometrics; CRC trans rs1005277 0.505 rs10827835 chr10:38150709 G/A cg17830980 chr10:43048298 ZNF37B 0.41 6.38 0.33 6e-10 Extrinsic epigenetic age acceleration; CRC cis rs6545883 0.868 rs2441381 chr2:61798829 C/T cg15711740 chr2:61764176 XPO1 -0.5 -6.84 -0.35 3.92e-11 Tuberculosis; CRC cis rs1862618 0.853 rs1862619 chr5:56098256 T/A cg03609598 chr5:56110824 MAP3K1 -0.8 -9.78 -0.47 5.44e-20 Initial pursuit acceleration; CRC cis rs12142240 0.660 rs72885163 chr1:46807117 C/A cg00530320 chr1:46809349 NSUN4 0.58 7.92 0.4 3.68e-14 Menopause (age at onset); CRC cis rs12760731 0.720 rs7524556 chr1:178446659 C/T cg00404053 chr1:178313656 RASAL2 0.87 9.66 0.47 1.31e-19 Obesity-related traits; CRC cis rs501120 0.513 rs1680639 chr10:44701754 T/G cg09554077 chr10:44749378 NA 0.67 7.47 0.38 7.27e-13 Coronary artery disease;Coronary heart disease; CRC cis rs9399135 0.967 rs7763836 chr6:135362378 T/C cg24558204 chr6:135376177 HBS1L 0.49 7.72 0.39 1.41e-13 Red blood cell count; CRC cis rs1218582 0.772 rs2174507 chr1:154887949 C/T cg03351412 chr1:154909251 PMVK 0.55 8.85 0.44 5.5e-17 Prostate cancer; CRC cis rs11148252 0.564 rs2296350 chr13:52710044 T/C cg00495681 chr13:53174319 NA 0.62 9.26 0.45 2.68e-18 Lewy body disease; CRC cis rs2836974 0.568 rs452377 chr21:40537183 T/C cg06238570 chr21:40685208 BRWD1 0.79 12.85 0.58 6.72e-31 Cognitive function; CRC cis rs7772486 0.790 rs6926657 chr6:146255794 G/A cg13319975 chr6:146136371 FBXO30 0.41 6.24 0.33 1.32e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs17270561 0.525 rs12201678 chr6:25978993 C/T cg17691542 chr6:26056736 HIST1H1C 0.99 11.54 0.54 4.33e-26 Iron status biomarkers; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg16410656 chr11:35965504 LDLRAD3 0.39 6.51 0.34 2.76e-10 Liver disease severity in Alagille syndrome; CRC cis rs9309473 1.000 rs7586463 chr2:73798476 T/C cg20560298 chr2:73613845 ALMS1 -0.47 -5.81 -0.3 1.5e-8 Metabolite levels; CRC trans rs7824557 0.564 rs2736288 chr8:11228100 G/A cg06636001 chr8:8085503 FLJ10661 -0.48 -7.34 -0.38 1.66e-12 Retinal vascular caliber; CRC cis rs10782582 0.593 rs12132750 chr1:76136222 A/G cg10523679 chr1:76189770 ACADM -0.4 -5.73 -0.3 2.28e-8 Daytime sleep phenotypes; CRC cis rs1008375 1.000 rs6818639 chr4:17633049 A/G cg04450456 chr4:17643702 FAM184B 0.41 6.7 0.35 8.9e-11 Parasitemia in Tripanosoma cruzi seropositivity; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg11343086 chr1:202113710 ARL8A 0.43 6.09 0.32 3.21e-9 Response to antipsychotic treatment; CRC cis rs3617 0.625 rs7612624 chr3:52893426 T/C cg18099408 chr3:52552593 STAB1 0.35 6.04 0.32 4.21e-9 Red blood cell count;Autism spectrum disorder or schizophrenia; CRC trans rs8002861 0.846 rs12428314 chr13:44476011 C/T cg12856521 chr11:46389249 DGKZ -0.43 -6.87 -0.35 3.31e-11 Leprosy; CRC trans rs2303319 0.504 rs16846026 chr2:162537691 T/C cg14875682 chr5:52083620 ITGA1;PELO -0.76 -6.16 -0.32 2.13e-9 Cognitive function; CRC cis rs9287719 0.649 rs10929677 chr2:10717548 A/G cg00105475 chr2:10696890 NA 0.45 7.07 0.36 9.39e-12 Prostate cancer; CRC cis rs6840360 1.000 rs3749562 chr4:152596540 T/C cg09659197 chr4:152720779 NA 0.52 11.34 0.53 2.16e-25 Intelligence (multi-trait analysis); CRC cis rs2032447 0.839 rs9356995 chr6:25996673 G/A cg27635394 chr6:26043820 HIST1H2BB 0.42 6.13 0.32 2.58e-9 Intelligence (multi-trait analysis); CRC cis rs7666738 0.830 rs4699592 chr4:98974202 A/C cg05340658 chr4:99064831 C4orf37 0.6 9.35 0.46 1.41e-18 Colonoscopy-negative controls vs population controls; CRC cis rs6089584 0.888 rs6061983 chr20:60621202 T/C cg23262073 chr20:60523788 NA -0.46 -7.16 -0.37 5.39e-12 Body mass index; CRC cis rs35110281 0.667 rs2070533 chr21:45122753 G/A cg01579765 chr21:45077557 HSF2BP -0.34 -6.3 -0.33 9.71e-10 Mean corpuscular volume; CRC cis rs951366 0.903 rs708723 chr1:205739266 C/T cg07157834 chr1:205819609 PM20D1 0.47 6.88 0.35 3.07e-11 Menarche (age at onset); CRC cis rs9660992 0.674 rs17345837 chr1:205263122 C/T cg21643547 chr1:205240462 TMCC2 -0.43 -6.94 -0.36 2.08e-11 Mean corpuscular volume;Mean platelet volume; CRC cis rs3749237 0.636 rs1568662 chr3:49521263 A/G cg07636037 chr3:49044803 WDR6 0.56 8.04 0.41 1.63e-14 Resting heart rate; CRC cis rs4969178 0.965 rs12450528 chr17:76395753 G/A cg05887092 chr17:76393375 PGS1 0.56 10.13 0.49 3.55e-21 HDL cholesterol levels; CRC cis rs1552244 0.554 rs58020561 chr3:10054682 A/G cg13047869 chr3:10149882 C3orf24 0.38 5.81 0.31 1.48e-8 Alzheimer's disease; CRC cis rs6076065 0.962 rs2424529 chr20:23369317 A/G cg11657817 chr20:23433608 CST11 0.38 6.01 0.31 4.98e-9 Facial morphology (factor 15, philtrum width); CRC cis rs9322193 0.961 rs9767713 chr6:149909377 T/G cg00933542 chr6:150070202 PCMT1 0.32 6.44 0.33 4.28e-10 Lung cancer; CRC trans rs28643277 0.671 rs7070136 chr10:15555388 A/G cg18315834 chr14:64909119 MTHFD1 0.42 6.06 0.32 3.67e-9 Periodontitis (CDC/AAP); CRC trans rs1656966 1.000 rs1656966 chr3:186466252 C/T cg14885145 chr10:104262292 SUFU;ACTR1A 0.42 6.42 0.33 4.84e-10 Myopia (pathological); CRC cis rs11690935 0.959 rs6709156 chr2:172591944 T/C cg13550731 chr2:172543902 DYNC1I2 -1.1 -18.53 -0.71 5.39e-53 Schizophrenia; CRC cis rs2857891 0.695 rs2248438 chr11:6985062 G/C cg04053776 chr11:6947353 ZNF215 0.4 6.24 0.33 1.33e-9 Response to cytadine analogues (cytosine arabinoside); CRC cis rs11711311 1.000 rs2712348 chr3:113460614 C/A cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.5 -6.86 -0.35 3.46e-11 IgG glycosylation; CRC cis rs67311347 1.000 rs9968170 chr3:40494274 A/G cg24209194 chr3:40518798 ZNF619 -0.43 -6.53 -0.34 2.45e-10 Renal cell carcinoma; CRC trans rs2303319 0.504 rs72873624 chr2:162481453 G/A cg12500891 chr11:57225987 NA -0.67 -6.03 -0.32 4.43e-9 Cognitive function; CRC cis rs6076065 0.723 rs2253925 chr20:23388021 C/G cg11657817 chr20:23433608 CST11 0.44 6.38 0.33 5.85e-10 Facial morphology (factor 15, philtrum width); CRC cis rs9297145 0.724 rs6958790 chr7:98774738 C/T cg05967295 chr7:98741636 SMURF1 -1.13 -17.65 -0.7 1.58e-49 Crohn's disease;Inflammatory bowel disease;Ulcerative colitis; CRC cis rs6543140 0.964 rs10196334 chr2:103090041 T/C cg03938978 chr2:103052716 IL18RAP 0.42 6.67 0.35 1.06e-10 Blood protein levels; CRC cis rs10832963 1.000 rs10832956 chr11:18645668 A/G cg09201001 chr11:18656081 SPTY2D1 0.74 11.54 0.54 4.25e-26 Breast cancer; CRC cis rs73206853 0.688 rs60971459 chr12:110702051 G/A cg12870014 chr12:110450643 ANKRD13A 0.8 7.72 0.39 1.39e-13 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC cis rs6952808 0.693 rs10950413 chr7:1912988 A/G cg04267008 chr7:1944627 MAD1L1 -0.65 -9.96 -0.48 1.35e-20 Bipolar disorder and schizophrenia; CRC cis rs9649213 0.555 rs34695842 chr7:97931062 G/T cg00277769 chr7:97922759 BAIAP2L1 -0.61 -10.75 -0.51 2.74e-23 Prostate cancer (SNP x SNP interaction); CRC cis rs2243480 1.000 rs7792391 chr7:65773429 A/G cg25985355 chr7:65971099 NA 0.51 5.79 0.3 1.6e-8 Diabetic kidney disease; CRC trans rs1728785 0.818 rs12926059 chr16:68569459 T/C cg04657470 chr2:198365150 HSPE1;HSPD1 0.58 6.97 0.36 1.72e-11 Ulcerative colitis; CRC cis rs514406 0.708 rs546334 chr1:53326210 T/C cg08859206 chr1:53392774 SCP2 -0.6 -9.62 -0.47 1.81e-19 Monocyte count; CRC cis rs68170813 0.641 rs1978085 chr7:107095216 T/C cg02696742 chr7:106810147 HBP1 -0.55 -5.94 -0.31 7.43e-9 Coronary artery disease; CRC cis rs951366 0.789 rs1775154 chr1:205696615 T/A cg14893161 chr1:205819251 PM20D1 0.83 13.16 0.59 4.52e-32 Menarche (age at onset); CRC cis rs9486715 0.838 rs7452350 chr6:96883326 C/A cg06623918 chr6:96969491 KIAA0776 1.02 20.3 0.75 5.5e-60 Headache; CRC cis rs7809950 1.000 rs7778270 chr7:107224667 A/G cg23024343 chr7:107201750 COG5 0.61 8.9 0.44 3.84e-17 Coronary artery disease; CRC cis rs853679 1.000 rs9986596 chr6:28219661 G/A cg12273811 chr6:28175739 NA 0.57 5.75 0.3 2.08e-8 Depression; CRC cis rs11764590 0.694 rs4721321 chr7:2068470 A/G cg14004847 chr7:1930337 MAD1L1 -0.42 -5.71 -0.3 2.51e-8 Neuroticism; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg22684426 chr12:49351253 ARF3 -0.43 -6.75 -0.35 6.56e-11 Myopia (pathological); CRC cis rs12760731 0.720 rs10913544 chr1:178350980 C/T cg00404053 chr1:178313656 RASAL2 0.86 8.8 0.44 7.6e-17 Obesity-related traits; CRC cis rs7772486 0.624 rs9485018 chr6:146025731 T/C cg23711669 chr6:146136114 FBXO30 -0.65 -10.71 -0.51 3.62e-23 Lobe attachment (rater-scored or self-reported); CRC cis rs11105298 0.891 rs10858881 chr12:89891474 T/G cg08166232 chr12:89918718 WDR51B;GALNT4 -0.61 -7.82 -0.4 7.45e-14 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; CRC cis rs172166 0.694 rs203876 chr6:28046673 T/C cg23161317 chr6:28129485 ZNF389 0.45 6.47 0.34 3.55e-10 Cardiac Troponin-T levels; CRC cis rs7493 1.000 rs7786401 chr7:95034001 G/T cg04871131 chr7:94954202 PON1 -0.46 -5.61 -0.3 4.36e-8 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs12143943 0.834 rs10900598 chr1:204525568 G/T cg17419461 chr1:204415978 PIK3C2B 0.4 6.31 0.33 8.87e-10 Cognitive performance; CRC cis rs2179367 0.959 rs514839 chr6:149648440 A/T cg11245181 chr6:149772854 ZC3H12D -0.4 -6.0 -0.31 5.26e-9 Dupuytren's disease; CRC cis rs35110281 0.693 rs2838344 chr21:45089877 C/T cg04455712 chr21:45112962 RRP1B 0.43 8.62 0.43 2.85e-16 Mean corpuscular volume; CRC trans rs208520 0.661 rs851466 chr6:66840476 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.08 -14.9 -0.63 9.49e-39 Exhaled nitric oxide output; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg26436829 chr16:86588937 MTHFSD;FLJ30679 0.41 6.06 0.32 3.81e-9 Response to antipsychotic treatment; CRC trans rs6833159 0.527 rs10939231 chr4:28829372 A/T ch.8.34907260F chr8:34787718 NA -0.43 -6.15 -0.32 2.26e-9 Underweight status; CRC cis rs2836974 1.000 rs12710454 chr21:40656919 A/G cg11890956 chr21:40555474 PSMG1 1.0 15.67 0.65 1.02e-41 Cognitive function; CRC cis rs7666738 0.830 rs1124253 chr4:98949682 C/T cg17366294 chr4:99064904 C4orf37 0.43 7.34 0.38 1.69e-12 Colonoscopy-negative controls vs population controls; CRC cis rs870825 0.860 rs72703526 chr4:185605676 A/T cg04058563 chr4:185651563 MLF1IP 0.55 5.62 0.3 3.98e-8 Blood protein levels; CRC cis rs2576037 0.526 rs10853544 chr18:44474194 T/C cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.55 9.25 0.45 2.95e-18 Personality dimensions; CRC cis rs7224685 0.569 rs34357603 chr17:4008760 G/A cg11204139 chr17:3907470 NA 0.53 6.77 0.35 5.76e-11 Type 2 diabetes; CRC cis rs9309711 0.623 rs7569694 chr2:3483390 T/G cg15506890 chr2:3487001 NA -0.54 -8.68 -0.43 1.88e-16 Neurofibrillary tangles; CRC cis rs4728302 0.869 rs889826 chr7:133595871 A/G cg10665199 chr7:133106180 EXOC4 0.38 5.79 0.3 1.66e-8 Intelligence;Intelligence (multi-trait analysis); CRC cis rs4819052 1.000 rs2838847 chr21:46670958 G/C cg11663144 chr21:46675770 NA -0.81 -12.46 -0.57 1.85e-29 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC trans rs2303319 0.504 rs62189043 chr2:162608466 A/T cg23247704 chr1:116518985 SLC22A15 -0.72 -6.14 -0.32 2.42e-9 Cognitive function; CRC cis rs7089973 0.872 rs17092497 chr10:116612628 G/A cg23260525 chr10:116636907 FAM160B1 0.31 6.81 0.35 4.58e-11 Bipolar disorder or attention deficit hyperactivity disorder; CRC cis rs2075165 0.870 rs12128955 chr1:156243821 C/T cg20302342 chr1:156215951 PAQR6 0.38 7.23 0.37 3.35e-12 Tonsillectomy; CRC cis rs9303280 0.901 rs2305479 chr17:38062217 C/T cg00129232 chr17:37814104 STARD3 -0.52 -8.44 -0.42 1.02e-15 Self-reported allergy; CRC cis rs72781680 0.678 rs872169 chr2:24259188 C/G cg20701182 chr2:24300061 SF3B14 0.6 6.72 0.35 8.11e-11 Lymphocyte counts; CRC cis rs796364 0.951 rs3098341 chr2:200792498 G/T cg12253985 chr2:200820533 C2orf60;C2orf47 0.6 6.61 0.34 1.58e-10 Schizophrenia; CRC cis rs12477438 0.798 rs2084987 chr2:99587885 C/T cg26064155 chr2:99771622 LIPT1;TSGA10 -0.77 -10.95 -0.52 5.49e-24 Chronic sinus infection; CRC trans rs6703335 0.870 rs10803142 chr1:243598234 A/G cg24341220 chr2:85581729 RETSAT;ELMOD3 0.42 6.0 0.31 5.17e-9 Schizophrenia;Schizophrenia, schizoaffective disorder or bipolar disorder; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg18047794 chr19:55770732 SAPS1 0.44 6.08 0.32 3.25e-9 Response to antipsychotic treatment; CRC cis rs172166 0.561 rs149973 chr6:27983613 G/T cg12172441 chr6:28176163 NA 0.44 6.39 0.33 5.72e-10 Cardiac Troponin-T levels; CRC trans rs6940638 1.000 rs12204280 chr6:27033104 T/C cg06606381 chr12:133084897 FBRSL1 -0.6 -6.52 -0.34 2.71e-10 Intelligence (multi-trait analysis); CRC cis rs9287719 0.934 rs6706763 chr2:10751407 C/T cg00105475 chr2:10696890 NA 0.45 7.17 0.37 4.86e-12 Prostate cancer; CRC cis rs10256972 0.521 rs7457418 chr7:1110255 C/T cg16145915 chr7:1198662 ZFAND2A -0.32 -6.12 -0.32 2.66e-9 Longevity;Endometriosis; CRC cis rs4665809 1.000 rs10170359 chr2:26272219 G/T cg04944784 chr2:26401820 FAM59B -0.66 -8.59 -0.43 3.56e-16 Gut microbiome composition (summer); CRC cis rs2652834 1.000 rs7181141 chr15:63398552 A/G cg05507819 chr15:63340323 TPM1 0.47 5.98 0.31 5.87e-9 HDL cholesterol; CRC trans rs2303319 0.504 rs56009150 chr2:162598582 T/C cg09481857 chr22:21368659 P2RX6;MGC16703 -0.65 -6.34 -0.33 7.73e-10 Cognitive function; CRC cis rs9393692 0.846 rs7771202 chr6:26279907 A/G cg13736514 chr6:26305472 NA -0.62 -11.75 -0.54 7.66e-27 Educational attainment; CRC cis rs7618915 0.547 rs1561337 chr3:52659963 C/T cg10802521 chr3:52805072 NEK4 -0.59 -9.1 -0.45 8.97e-18 Bipolar disorder; CRC cis rs78456975 1.000 rs10205916 chr2:1558451 A/T cg26248373 chr2:1572462 NA 0.65 7.07 0.36 9.51e-12 Placebo response in major depressive disorder (% change in symptom score); CRC cis rs10089 0.904 rs2195921 chr5:127489754 A/C cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.71 10.0 0.48 9.56e-21 Ileal carcinoids; CRC cis rs10971721 0.822 rs72727340 chr9:33936734 T/C cg13495928 chr9:33750294 PRSS3 0.56 5.95 0.31 6.96e-9 Body mass index; CRC trans rs66887589 0.967 rs1480933 chr4:120433248 C/T cg25214090 chr10:38739885 LOC399744 0.4 6.28 0.33 1.08e-9 Diastolic blood pressure; CRC cis rs13064411 0.518 rs9842559 chr3:113252705 A/C cg18753928 chr3:113234510 CCDC52 -0.49 -7.79 -0.39 8.81e-14 Response to simvastatin treatment (PCSK9 protein level change); CRC cis rs7552404 1.000 rs4949674 chr1:76213715 C/A cg22875332 chr1:76189707 ACADM 0.69 9.34 0.46 1.45e-18 Blood metabolite levels;Acylcarnitine levels; CRC cis rs853679 0.517 rs2273564 chr6:28057594 A/T cg12273811 chr6:28175739 NA 0.74 9.41 0.46 8.58e-19 Depression; CRC cis rs274567 0.501 rs274571 chr5:131712125 A/G cg02033258 chr5:131593261 PDLIM4 -0.39 -6.58 -0.34 1.89e-10 Blood metabolite levels; CRC trans rs916888 0.821 rs70600 chr17:44860021 C/T cg22433210 chr17:43662623 NA 0.87 9.32 0.46 1.8e-18 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs1008375 0.931 rs6813374 chr4:17649494 T/C cg04450456 chr4:17643702 FAM184B 0.37 5.88 0.31 9.91e-9 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs868036 0.958 rs4261478 chr15:68074084 G/A cg05925327 chr15:68127851 NA -0.3 -5.74 -0.3 2.14e-8 Restless legs syndrome; CRC cis rs9910055 0.529 rs228767 chr17:42188311 C/G cg09913183 chr17:42254507 C17orf65;ASB16 -0.5 -6.75 -0.35 6.88e-11 Total body bone mineral density; CRC cis rs1971762 0.545 rs7485472 chr12:54044438 T/C cg06632207 chr12:54070931 ATP5G2 0.5 8.73 0.43 1.33e-16 Height; CRC cis rs939658 0.776 rs35904425 chr15:79444567 G/A cg17916960 chr15:79447300 NA -0.44 -7.15 -0.37 5.54e-12 Refractive error; CRC cis rs1005277 0.579 rs176886 chr10:38403974 C/T cg00409905 chr10:38381863 ZNF37A -0.68 -11.31 -0.53 2.81e-25 Extrinsic epigenetic age acceleration; CRC cis rs12711979 0.765 rs897069 chr2:3818947 C/T cg17052675 chr2:3827356 NA 0.55 10.41 0.5 3.84e-22 Itch intensity from mosquito bite adjusted by bite size; CRC cis rs877282 0.853 rs7069720 chr10:754487 A/G cg17470449 chr10:769945 NA 0.61 7.96 0.4 2.78e-14 Uric acid levels; CRC cis rs11123610 0.520 rs66557864 chr2:3720812 C/A cg25251562 chr2:3704773 ALLC -0.49 -6.16 -0.32 2.09e-9 Response to inhaled corticosteroid treatment in asthma (change in FEV1); CRC cis rs801193 0.660 rs4610622 chr7:66224497 T/C cg00343986 chr7:65444356 GUSB 0.44 6.29 0.33 1.04e-9 Aortic root size; CRC cis rs7772486 0.659 rs9376957 chr6:146011064 C/T cg23711669 chr6:146136114 FBXO30 -0.65 -10.75 -0.51 2.71e-23 Lobe attachment (rater-scored or self-reported); CRC cis rs12889267 0.551 rs12432623 chr14:21588779 G/T cg02988727 chr14:21567520 ZNF219;C14orf176 -0.46 -6.18 -0.32 1.94e-9 Hematocrit;Resting heart rate; CRC cis rs7705042 0.865 rs6882226 chr5:141503870 T/A cg08523384 chr5:141488047 NDFIP1 -0.33 -5.83 -0.31 1.31e-8 Asthma; CRC cis rs11098499 0.874 rs17839089 chr4:120111069 A/G cg24375607 chr4:120327624 NA 0.48 7.25 0.37 3.02e-12 Corneal astigmatism; CRC trans rs9585327 0.584 rs4772260 chr13:100645723 A/G cg16095767 chr12:122110467 NA 0.38 6.11 0.32 2.86e-9 Myopia; CRC trans rs10802346 0.515 rs1113270 chr1:246423217 A/G cg13514129 chr1:39547527 MACF1 0.69 11.08 0.52 1.91e-24 Fractional exhaled nitric oxide (childhood); CRC cis rs7605827 0.893 rs7572131 chr2:15691886 G/A cg19274914 chr2:15703543 NA 0.38 5.8 0.3 1.59e-8 Educational attainment (years of education); CRC cis rs524281 0.861 rs7935336 chr11:65865325 C/T cg14036092 chr11:66035641 RAB1B -0.47 -5.7 -0.3 2.6e-8 Electroencephalogram traits; CRC cis rs12230513 0.632 rs59213907 chr12:55728911 A/T cg23425280 chr12:56401806 NA 0.48 5.87 0.31 1.07e-8 Contrast sensitivity; CRC cis rs1153858 1.000 rs28679834 chr15:45616206 C/T cg21132104 chr15:45694354 SPATA5L1 0.56 7.94 0.4 3.3e-14 Homoarginine levels; CRC cis rs951366 1.000 rs951366 chr1:205685352 C/T cg17178900 chr1:205818956 PM20D1 0.45 6.49 0.34 3.08e-10 Menarche (age at onset); CRC cis rs9911578 1.000 rs654778 chr17:56736473 A/C cg05425664 chr17:57184151 TRIM37 -0.5 -7.96 -0.4 2.78e-14 Intelligence (multi-trait analysis); CRC cis rs10256972 0.524 rs6945202 chr7:1116558 T/C cg04025307 chr7:1156635 C7orf50 0.62 9.6 0.47 2.15e-19 Longevity;Endometriosis; CRC cis rs11212617 0.967 rs227053 chr11:108226855 A/T cg12106634 chr11:108092400 ATM;NPAT 0.42 6.11 0.32 2.8e-9 Response to metformin in type 2 diabetes (glycemic); CRC cis rs897984 0.762 rs7204459 chr16:30984212 G/A cg00531865 chr16:30841666 NA 0.47 6.59 0.34 1.75e-10 Dementia with Lewy bodies; CRC cis rs832540 0.669 rs832539 chr5:56199386 A/C cg12311346 chr5:56204834 C5orf35 -0.55 -8.15 -0.41 7.87e-15 Coronary artery disease; CRC cis rs950776 0.518 rs12591557 chr15:78811732 A/G cg22563815 chr15:78856949 CHRNA5 0.31 5.7 0.3 2.63e-8 Sudden cardiac arrest; CRC cis rs4819052 0.851 rs7279011 chr21:46655995 G/A cg11663144 chr21:46675770 NA -0.8 -12.76 -0.58 1.42e-30 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg26480543 chr19:55629279 PPP1R12C 0.46 6.73 0.35 7.56e-11 Intelligence (multi-trait analysis); CRC cis rs7613875 0.543 rs34034116 chr3:49959156 C/A cg24308560 chr3:49941425 MST1R -0.44 -6.65 -0.34 1.23e-10 Body mass index; CRC cis rs6866614 0.608 rs17132288 chr5:131336105 C/T cg11843238 chr5:131593191 PDLIM4 0.32 5.79 0.3 1.63e-8 Perceived unattractiveness to mosquitoes; CRC cis rs6743376 0.556 rs1530548 chr2:113817402 G/A cg24553058 chr2:113831203 IL1F10 0.43 6.97 0.36 1.69e-11 Inflammatory biomarkers; CRC cis rs1403694 0.515 rs5030058 chr3:186452415 T/G cg04611788 chr3:186434169 KNG1 -0.58 -8.36 -0.42 1.79e-15 Blood protein levels; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg08652404 chr7:99098009 ZNF394 0.44 6.41 0.33 5.12e-10 Intelligence (multi-trait analysis); CRC cis rs8078723 0.763 rs4433838 chr17:38143532 C/T cg17467752 chr17:38218738 THRA -0.57 -8.94 -0.44 2.92e-17 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); CRC cis rs7809950 0.953 rs2237670 chr7:107131485 A/G cg23024343 chr7:107201750 COG5 -0.6 -8.59 -0.43 3.44e-16 Coronary artery disease; CRC cis rs7264396 0.943 rs11167267 chr20:34109273 G/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.41 -6.66 -0.34 1.16e-10 Total cholesterol levels; CRC cis rs965469 0.895 rs6139124 chr20:3398144 C/T cg25506879 chr20:3388711 C20orf194 -0.42 -6.3 -0.33 9.7e-10 IFN-related cytopenia; CRC cis rs9733 0.596 rs2867301 chr1:150653795 C/T cg18016565 chr1:150552671 MCL1 0.46 6.74 0.35 6.91e-11 Tonsillectomy; CRC cis rs875971 1.000 rs6961990 chr7:65888570 C/A cg18876405 chr7:65276391 NA 0.51 8.76 0.43 1.07e-16 Aortic root size; CRC trans rs7267979 1.000 rs11100 chr20:25281184 G/C cg17903999 chr18:56338584 MALT1 -0.42 -6.99 -0.36 1.52e-11 Liver enzyme levels (alkaline phosphatase); CRC cis rs2239547 0.522 rs9831409 chr3:52985711 A/T cg18404041 chr3:52824283 ITIH1 0.33 6.6 0.34 1.66e-10 Schizophrenia; CRC cis rs875971 0.862 rs11769079 chr7:65842128 G/A cg11764359 chr7:65958608 NA 0.59 9.08 0.45 1.06e-17 Aortic root size; CRC cis rs1950500 0.550 rs7148384 chr14:24828814 C/T cg01658259 chr14:24837143 NFATC4 0.5 6.73 0.35 7.66e-11 Height; CRC cis rs4713118 0.824 rs742046 chr6:27739254 A/G cg19041857 chr6:27730383 NA -0.44 -6.06 -0.32 3.81e-9 Parkinson's disease; CRC cis rs11971779 0.553 rs11973507 chr7:139099461 A/T cg07862535 chr7:139043722 LUC7L2 0.57 7.32 0.37 1.92e-12 Diisocyanate-induced asthma; CRC cis rs4665809 1.000 rs750452 chr2:26324995 G/A cg26119090 chr2:26468346 HADHA;HADHB -0.61 -7.88 -0.4 4.97e-14 Gut microbiome composition (summer); CRC cis rs12580194 0.593 rs7959837 chr12:55734511 G/A cg23425280 chr12:56401806 NA 0.52 6.36 0.33 6.8e-10 Cancer; CRC cis rs1862618 0.756 rs9292125 chr5:56107200 C/T cg20203395 chr5:56204925 C5orf35 -0.67 -7.99 -0.4 2.23e-14 Initial pursuit acceleration; CRC cis rs3736594 0.546 rs6734059 chr2:27808154 C/T cg27432699 chr2:27873401 GPN1 -0.61 -8.15 -0.41 7.9e-15 Fasting blood glucose;Fasting blood glucose (BMI interaction); CRC cis rs1881797 1.000 rs10158379 chr1:247686352 C/A cg05639522 chr1:247681581 NA 0.46 6.98 0.36 1.68e-11 Acute lymphoblastic leukemia (childhood); CRC cis rs4654899 0.865 rs10493006 chr1:21375904 G/A cg02927042 chr1:21476669 EIF4G3 -0.46 -6.92 -0.36 2.41e-11 Superior frontal gyrus grey matter volume; CRC cis rs357618 1.000 rs165351 chr5:150854881 C/T cg03212797 chr5:150827313 SLC36A1 -0.37 -5.62 -0.3 4.01e-8 Basophil percentage of white cells; CRC cis rs208520 0.742 rs208454 chr6:66907783 T/C cg07460842 chr6:66804631 NA -0.92 -11.51 -0.54 5.56e-26 Exhaled nitric oxide output; CRC trans rs11039798 0.588 rs7116858 chr11:48543920 C/A cg03929089 chr4:120376271 NA 0.65 6.79 0.35 5.15e-11 Axial length; CRC cis rs1044826 0.642 rs2118981 chr3:139178853 A/G cg15131784 chr3:139108705 COPB2 0.41 6.07 0.32 3.43e-9 Obesity-related traits; CRC trans rs2303319 0.504 rs62189042 chr2:162602320 G/T cg23247704 chr1:116518985 SLC22A15 -0.72 -6.14 -0.32 2.42e-9 Cognitive function; CRC cis rs6968419 0.755 rs3823977 chr7:115893407 A/T cg02561103 chr7:115862891 TES -0.43 -6.53 -0.34 2.54e-10 Intraocular pressure; CRC cis rs7666738 0.753 rs13111199 chr4:98953705 A/G cg05340658 chr4:99064831 C4orf37 0.61 9.54 0.47 3.45e-19 Colonoscopy-negative controls vs population controls; CRC cis rs55879323 1 rs55879323 chr1:152168740 C/T cg23107878 chr1:152161397 NA 0.42 6.2 0.32 1.7e-9 Inflammatory skin disease; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg22713345 chr19:8070804 ELAVL1 0.46 6.14 0.32 2.35e-9 Anxiety disorder; CRC cis rs3849570 0.643 rs9870954 chr3:81978850 A/G cg07356753 chr3:81810745 GBE1 -0.49 -6.57 -0.34 1.94e-10 Waist circumference;Body mass index; CRC cis rs2976388 0.590 rs4736322 chr8:143822208 T/C cg24634471 chr8:143751801 JRK -0.45 -6.4 -0.33 5.28e-10 Urinary tract infection frequency; CRC cis rs1552244 0.882 rs34706481 chr3:10004123 G/A cg02579736 chr3:10068473 FANCD2;CIDECP 0.9 10.69 0.51 4.34e-23 Alzheimer's disease; CRC cis rs1218582 0.772 rs7528532 chr1:154874440 C/T cg06221963 chr1:154839813 KCNN3 -0.76 -15.38 -0.65 1.34e-40 Prostate cancer; CRC cis rs908922 0.676 rs11205018 chr1:152496249 T/G cg09873164 chr1:152488093 CRCT1 0.37 6.13 0.32 2.45e-9 Hair morphology; CRC cis rs908922 0.676 rs2282296 chr1:152487979 C/T cg23254163 chr1:152506842 NA 0.5 10.06 0.49 5.98e-21 Hair morphology; CRC cis rs2576037 0.901 rs2571021 chr18:44583498 A/G cg19077165 chr18:44547161 KATNAL2 0.46 7.51 0.38 5.78e-13 Personality dimensions; CRC cis rs12477438 0.559 rs6733285 chr2:99725575 T/C cg14399236 chr2:99771627 LIPT1;TSGA10 0.72 12.02 0.55 7.68e-28 Chronic sinus infection; CRC cis rs1997103 1.000 rs7779040 chr7:55412947 T/C cg17469321 chr7:55412551 NA 0.74 11.73 0.54 8.89e-27 QRS interval (sulfonylurea treatment interaction); CRC cis rs7945705 0.791 rs6484484 chr11:8817206 A/G cg00186954 chr11:8933980 ST5;C11orf17 0.35 5.73 0.3 2.23e-8 Hemoglobin concentration; CRC cis rs9916302 0.851 rs6503518 chr17:37660469 A/G cg00129232 chr17:37814104 STARD3 -0.55 -8.11 -0.41 9.98e-15 Glomerular filtration rate (creatinine); CRC cis rs13315871 0.929 rs9842917 chr3:58244800 C/T cg20936604 chr3:58311152 NA -0.67 -6.82 -0.35 4.3e-11 Cholesterol, total; CRC cis rs7589728 1.000 rs75309929 chr2:88524377 T/C cg14558114 chr2:88469736 THNSL2 0.58 5.79 0.3 1.64e-8 Plasma clusterin levels; CRC cis rs3785574 0.962 rs62077509 chr17:61848973 A/G cg11494091 chr17:61959527 GH2 0.38 5.93 0.31 7.85e-9 Height; CRC cis rs3767633 0.925 rs2134696 chr1:161781200 A/T cg09175582 chr1:161736000 ATF6 -0.62 -5.95 -0.31 6.76e-9 IgG glycosylation; CRC trans rs701145 0.556 rs355758 chr3:154007682 C/G cg22545385 chr10:131989303 NA 0.42 6.13 0.32 2.55e-9 Coronary artery disease; CRC cis rs7762018 1.000 rs7746598 chr6:170084933 T/A cg19338460 chr6:170058176 WDR27 -0.76 -8.29 -0.42 2.95e-15 Thiazide-induced adverse metabolic effects in hypertensive patients; CRC cis rs1843834 0.611 rs1058360 chr2:225449242 A/T cg22509189 chr2:225307070 NA -0.39 -5.82 -0.31 1.38e-8 IgE levels in asthmatics (D.p. specific); CRC cis rs2976388 0.609 rs2585149 chr8:143793320 T/C cg20041105 chr8:143859282 LYNX1 0.46 8.24 0.41 4.25e-15 Urinary tract infection frequency; CRC cis rs3749237 0.595 rs6784820 chr3:49450864 C/T cg03060546 chr3:49711283 APEH -0.68 -11.84 -0.55 3.49e-27 Resting heart rate; CRC cis rs6496667 0.865 rs7163230 chr15:90884621 T/C cg04176472 chr15:90893244 GABARAPL3 0.56 6.42 0.33 4.72e-10 Rheumatoid arthritis; CRC cis rs10193935 0.901 rs1496329 chr2:42688797 T/C cg27598129 chr2:42591480 NA 0.7 7.98 0.4 2.51e-14 Colonoscopy-negative controls vs population controls; CRC cis rs10450586 0.863 rs7123838 chr11:27303826 C/T cg10370305 chr11:27303972 NA 0.4 6.47 0.34 3.45e-10 Total body bone mineral density; CRC cis rs911555 0.570 rs11625397 chr14:104027557 A/G cg24130564 chr14:104152367 KLC1 0.69 10.83 0.51 1.36e-23 Intelligence (multi-trait analysis); CRC cis rs9549328 0.589 rs34144481 chr13:113617322 T/G cg08614441 chr13:113633676 MCF2L 0.4 7.06 0.36 1e-11 Systolic blood pressure; CRC cis rs2153535 0.580 rs6597325 chr6:8461053 A/C cg21535247 chr6:8435926 SLC35B3 0.5 7.56 0.38 4.13e-13 Motion sickness; CRC cis rs739401 0.572 rs410820 chr11:3080102 G/A cg05729581 chr11:3078854 CARS -0.6 -8.72 -0.43 1.4e-16 Longevity; CRC cis rs2842992 0.789 rs4709376 chr6:160226337 A/G cg19482086 chr6:160211437 TCP1;MRPL18 0.74 9.43 0.46 7.57e-19 Age-related macular degeneration (geographic atrophy); CRC cis rs35110281 0.805 rs8131005 chr21:45041954 T/C cg04455712 chr21:45112962 RRP1B 0.39 7.54 0.38 4.64e-13 Mean corpuscular volume; CRC cis rs1552244 0.608 rs7615408 chr3:10000186 A/G cg00166722 chr3:10149974 C3orf24 0.45 6.83 0.35 4.21e-11 Alzheimer's disease; CRC cis rs2976388 0.609 rs2572907 chr8:143801938 G/A cg04969067 chr8:143858791 LYNX1 0.44 7.49 0.38 6.29e-13 Urinary tract infection frequency; CRC cis rs2180341 0.960 rs3756996 chr6:127664258 G/C cg27446573 chr6:127587934 RNF146 0.99 14.12 0.61 1.01e-35 Breast cancer; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg08245420 chr5:139726438 HBEGF 0.42 6.09 0.32 3.16e-9 Intelligence (multi-trait analysis); CRC trans rs991639 0.697 rs13085229 chr3:94802 A/G cg08213608 chr4:3748254 NA 0.51 6.25 0.33 1.26e-9 Problematic alcohol use in trauma-exposed individuals; CRC cis rs11155671 0.530 rs9383940 chr6:150226059 T/G cg07701084 chr6:150067640 NUP43 0.42 6.08 0.32 3.3e-9 Testicular germ cell tumor; CRC cis rs62229266 0.804 rs11088331 chr21:37421872 T/C cg08632701 chr21:37451849 NA -0.45 -7.15 -0.37 5.77e-12 Mitral valve prolapse; CRC cis rs1448094 0.845 rs11117129 chr12:86349390 A/G cg00310523 chr12:86230176 RASSF9 0.44 7.48 0.38 7.04e-13 Major depressive disorder; CRC cis rs2688482 0.557 rs2550236 chr3:195522321 A/G cg05834845 chr3:195489306 MUC4 0.67 7.37 0.38 1.43e-12 Lung disease severity in cystic fibrosis; CRC cis rs2276314 1.000 rs9304154 chr18:33562227 C/T cg05985134 chr18:33552581 C18orf21 0.45 5.85 0.31 1.19e-8 Endometriosis;Drug-induced torsades de pointes; CRC cis rs2730245 0.527 rs2657362 chr7:158685095 A/G cg24397884 chr7:158709396 WDR60 0.92 11.35 0.53 2.01e-25 Height; CRC trans rs6598955 0.671 rs17163749 chr1:26568165 A/G cg07461501 chr17:79650226 HGS;ARL16 -0.51 -6.04 -0.32 4.26e-9 Obesity-related traits; CRC cis rs311392 0.902 rs438437 chr8:55094187 G/C cg06042504 chr8:55087323 NA -0.43 -6.75 -0.35 6.83e-11 Pelvic organ prolapse (moderate/severe); CRC cis rs11098499 0.754 rs10212775 chr4:120239244 G/C cg24375607 chr4:120327624 NA 0.48 7.64 0.39 2.32e-13 Corneal astigmatism; CRC cis rs7258465 1.000 rs10403249 chr19:18604942 T/C cg06462663 chr19:18546047 ISYNA1 0.46 7.07 0.36 9.28e-12 Breast cancer; CRC cis rs6088580 0.634 rs6059866 chr20:33075810 A/C cg08999081 chr20:33150536 PIGU 0.54 10.03 0.48 7.93e-21 Glomerular filtration rate (creatinine); CRC cis rs10504229 0.728 rs17216187 chr8:58158778 G/T cg05313129 chr8:58192883 C8orf71 -0.48 -6.25 -0.33 1.29e-9 Developmental language disorder (linguistic errors); CRC cis rs801193 0.591 rs721717 chr7:66130292 G/T cg12463550 chr7:65579703 CRCP -0.46 -6.16 -0.32 2.1e-9 Aortic root size; CRC cis rs17608059 0.518 rs4792436 chr17:13972307 T/A cg27005118 chr17:13972210 COX10 0.45 10.63 0.51 6.99e-23 Temperament; CRC cis rs2732480 0.577 rs2732479 chr12:48736260 A/C cg21466736 chr12:48725269 NA -0.61 -9.06 -0.45 1.18e-17 Hemoglobin concentration;Red blood cell count;Hematocrit; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg14831266 chr1:33283905 YARS;S100PBP 0.46 6.42 0.33 4.84e-10 Response to antipsychotic treatment; CRC cis rs2806561 0.894 rs628106 chr1:23537685 C/T cg19743168 chr1:23544995 NA 0.37 5.94 0.31 7.21e-9 Height; CRC trans rs875971 0.660 rs2191268 chr7:66110224 C/T cg23784313 chr12:15942613 EPS8 -0.4 -6.48 -0.34 3.37e-10 Aortic root size; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G ch.1.64660926R chr1:64888338 NA 0.47 7.42 0.38 1.01e-12 Liver disease severity in Alagille syndrome; CRC cis rs7918232 0.800 rs7907981 chr10:27444329 T/C cg14240646 chr10:27532245 ACBD5 -0.8 -10.16 -0.49 2.83e-21 Breast cancer; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg07892339 chr1:156721493 HDGF 0.46 6.82 0.35 4.26e-11 Intelligence (multi-trait analysis); CRC cis rs7659604 1.000 rs72678650 chr4:122666000 A/G cg06713675 chr4:122721982 EXOSC9 -0.4 -6.56 -0.34 2.05e-10 Type 2 diabetes; CRC cis rs6662572 0.686 rs72690855 chr1:46266210 G/C cg03123370 chr1:45965343 CCDC163P;MMACHC 0.48 5.91 0.31 8.39e-9 Blood protein levels; CRC cis rs11679072 1.000 rs6741183 chr2:240448959 A/G cg03276489 chr2:240449683 NA -0.84 -8.79 -0.44 8.4e-17 Blood pressure (smoking interaction); CRC cis rs595982 0.527 rs56021835 chr19:49369989 G/A cg21252483 chr19:49399788 TULP2 -0.36 -5.88 -0.31 9.94e-9 Red cell distribution width; CRC trans rs7267979 0.706 rs6037069 chr20:25234166 C/T cg17903999 chr18:56338584 MALT1 -0.41 -6.54 -0.34 2.39e-10 Liver enzyme levels (alkaline phosphatase); CRC cis rs769267 0.965 rs2023882 chr19:19405405 T/C cg20644253 chr19:19431407 KIAA0892;SF4 0.43 6.04 0.32 4.25e-9 Tonsillectomy; CRC cis rs7949030 0.523 rs12223627 chr11:62368557 G/C cg13298116 chr11:62369859 EML3;MTA2 0.57 9.03 0.45 1.44e-17 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; CRC cis rs9309473 0.632 rs6546825 chr2:73592253 G/C cg20560298 chr2:73613845 ALMS1 -0.48 -6.51 -0.34 2.82e-10 Metabolite levels; CRC cis rs6582630 0.502 rs2387603 chr12:38353389 A/C cg26384229 chr12:38710491 ALG10B 0.68 9.77 0.47 5.8e-20 Drug-induced liver injury (flucloxacillin); CRC cis rs1878931 1.000 rs1878931 chr16:3450907 G/C cg26668626 chr16:3451006 ZNF174;ZNF434 0.75 11.03 0.52 2.76e-24 Body mass index (adult); CRC cis rs7647973 0.922 rs57273516 chr3:49483074 A/G cg07636037 chr3:49044803 WDR6 0.66 8.09 0.41 1.14e-14 Menarche (age at onset); CRC cis rs8180040 0.934 rs62260710 chr3:47564462 C/G cg02527881 chr3:46936655 PTH1R 0.37 6.75 0.35 6.76e-11 Colorectal cancer; CRC cis rs4750440 0.702 rs7918501 chr10:14029895 C/T cg00551146 chr10:14014579 FRMD4A 0.36 5.85 0.31 1.21e-8 Adiponectin levels; CRC cis rs2976388 0.647 rs2572906 chr8:143798269 G/A cg24046110 chr8:143859143 LYNX1 0.46 8.11 0.41 9.8e-15 Urinary tract infection frequency; CRC cis rs10504229 1.000 rs66936919 chr8:58172868 C/G cg01721255 chr8:58191610 C8orf71 0.47 6.02 0.31 4.74e-9 Developmental language disorder (linguistic errors); CRC cis rs9311474 0.629 rs11709284 chr3:52559705 G/A cg08365687 chr3:52569147 NT5DC2;LOC440957 0.35 5.74 0.3 2.18e-8 Electroencephalogram traits; CRC cis rs2576037 0.558 rs7244778 chr18:44541915 T/C cg07643061 chr18:44555308 TCEB3C;TCEB3CL;KATNAL2 -0.34 -5.66 -0.3 3.3e-8 Personality dimensions; CRC cis rs9368481 0.646 rs75843621 chr6:26967881 G/A cg12292205 chr6:26970375 C6orf41 -0.73 -11.84 -0.55 3.64e-27 Autism spectrum disorder or schizophrenia; CRC cis rs8105895 0.935 rs10412953 chr19:22238482 C/G cg02657401 chr19:22469223 NA -0.34 -5.65 -0.3 3.56e-8 Body mass index (change over time); CRC cis rs4731207 0.698 rs10233306 chr7:124498417 G/C cg23710748 chr7:124431027 NA -0.38 -6.08 -0.32 3.42e-9 Cutaneous malignant melanoma; CRC cis rs17253792 0.642 rs10483648 chr14:56104278 T/C cg24579896 chr14:56047964 C14orf33;KTN1 0.71 5.67 0.3 3.16e-8 Putamen volume; CRC cis rs10504229 0.639 rs72650811 chr8:58115661 G/A cg24829409 chr8:58192753 C8orf71 -0.55 -8.03 -0.4 1.71e-14 Developmental language disorder (linguistic errors); CRC cis rs2179367 0.959 rs562428 chr6:149647525 T/C cg11245181 chr6:149772854 ZC3H12D -0.41 -6.06 -0.32 3.65e-9 Dupuytren's disease; CRC cis rs3820068 0.581 rs67806552 chr1:15927138 T/C cg24675056 chr1:15929824 NA 0.52 7.27 0.37 2.64e-12 Systolic blood pressure; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg06893123 chr16:3185027 ZNF213 0.45 5.97 0.31 6.2e-9 Anxiety disorder; CRC cis rs7945705 0.935 rs11042103 chr11:8888700 C/T cg21881798 chr11:8931708 C11orf17;ST5 0.66 10.2 0.49 2.08e-21 Hemoglobin concentration; CRC trans rs12478296 1.000 rs7420157 chr2:243005204 G/A cg06834434 chr14:75079333 LTBP2 0.55 6.62 0.34 1.47e-10 Obesity-related traits; CRC cis rs4332037 0.722 rs55934553 chr7:1914059 T/C cg25834613 chr7:1915315 MAD1L1 -0.47 -7.38 -0.38 1.3e-12 Bipolar disorder; CRC cis rs34172651 0.517 rs2547040 chr16:24736408 G/C cg06505273 chr16:24850292 NA -0.5 -6.4 -0.33 5.35e-10 Intelligence (multi-trait analysis); CRC cis rs1018836 0.828 rs7012741 chr8:91536065 A/G cg16814680 chr8:91681699 NA -0.57 -8.55 -0.43 4.86e-16 Ejection fraction in Tripanosoma cruzi seropositivity; CRC cis rs10046574 0.561 rs10226494 chr7:135214412 C/G cg27474649 chr7:135195673 CNOT4 0.59 5.97 0.31 6.08e-9 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs7626444 0.625 rs843529 chr3:196480595 A/G cg12930392 chr3:196481615 PAK2 -0.38 -6.88 -0.35 3.05e-11 Monocyte count; CRC cis rs6088590 0.965 rs6087619 chr20:33288511 C/G cg08999081 chr20:33150536 PIGU 0.54 9.2 0.45 4.28e-18 Coronary artery disease; CRC cis rs2404602 0.647 rs34103231 chr15:76912690 A/G cg03037974 chr15:76606532 NA -0.5 -7.15 -0.37 5.67e-12 Blood metabolite levels; CRC cis rs7762018 1.000 rs4716378 chr6:170086568 G/C cg24289452 chr6:170231220 NA -0.6 -6.57 -0.34 2.01e-10 Thiazide-induced adverse metabolic effects in hypertensive patients; CRC cis rs28493229 0.708 rs10407650 chr19:41160970 T/C cg21869046 chr19:41225005 ITPKC 0.41 6.15 0.32 2.26e-9 Kawasaki disease; CRC cis rs2404602 0.716 rs7164060 chr15:76707694 T/C cg22467129 chr15:76604101 ETFA -0.43 -7.22 -0.37 3.53e-12 Blood metabolite levels; CRC cis rs10504229 0.724 rs16922734 chr8:58111192 C/T cg22535103 chr8:58192502 C8orf71 -0.7 -9.2 -0.45 4.33e-18 Developmental language disorder (linguistic errors); CRC cis rs853679 0.542 rs9380063 chr6:28137853 A/G cg12273811 chr6:28175739 NA 0.73 9.16 0.45 5.8e-18 Depression; CRC cis rs4862750 0.872 rs6852907 chr4:187897094 A/C cg22105103 chr4:187893119 NA 0.63 11.52 0.54 4.85e-26 Lobe attachment (rater-scored or self-reported); CRC cis rs76878669 0.561 rs7115577 chr11:66172258 G/T cg18002602 chr11:66138449 SLC29A2 -0.27 -5.75 -0.3 2.09e-8 Educational attainment (years of education); CRC cis rs2878628 0.650 rs56098033 chr3:52758571 T/A cg08222913 chr3:52553049 STAB1 -0.34 -6.17 -0.32 2e-9 Intelligence (multi-trait analysis); CRC cis rs736408 0.522 rs11716747 chr3:52748857 C/T cg05573699 chr3:52720067 GNL3;PBRM1 -0.48 -6.95 -0.36 2.01e-11 Bipolar disorder; CRC cis rs1983170 0.735 rs963910 chr1:92014136 T/C cg22013790 chr1:91990662 CDC7 0.42 6.11 0.32 2.79e-9 Eosinophil percentage of white cells; CRC trans rs11098499 0.863 rs11723090 chr4:120490592 T/C cg25214090 chr10:38739885 LOC399744 0.67 10.24 0.49 1.58e-21 Corneal astigmatism; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg23475963 chr7:128379258 CALU 0.46 6.46 0.34 3.85e-10 Response to antipsychotic treatment; CRC cis rs968567 0.501 rs174553 chr11:61575158 A/G cg00603274 chr11:61596626 FADS2 -0.44 -6.4 -0.33 5.33e-10 Blood metabolite levels;Rheumatoid arthritis;Vitiligo;Glycerophospholipid levels; CRC cis rs4713118 0.513 rs183244 chr6:28031838 C/A cg15786705 chr6:28176104 NA 0.58 8.14 0.41 8.31e-15 Parkinson's disease; CRC cis rs1707322 0.686 rs3014242 chr1:46087577 G/A cg06784218 chr1:46089804 CCDC17 -0.66 -12.03 -0.55 6.97e-28 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs4638749 0.651 rs13385677 chr2:108826152 T/C cg25838818 chr2:108905173 SULT1C2 -0.35 -5.85 -0.31 1.17e-8 Blood pressure; CRC cis rs2836974 0.897 rs11911112 chr21:40528346 A/C cg11644478 chr21:40555479 PSMG1 0.82 13.53 0.6 1.81e-33 Cognitive function; CRC cis rs4237845 0.837 rs7954591 chr12:58299037 A/G cg02175503 chr12:58329896 NA 0.62 8.97 0.44 2.25e-17 Intelligence (multi-trait analysis); CRC cis rs2880765 0.743 rs16940052 chr15:86006674 G/A cg17133734 chr15:86042851 AKAP13 0.41 6.45 0.33 4.03e-10 Coronary artery disease; CRC cis rs12826942 0.959 rs34507359 chr12:42736831 A/G cg11827402 chr12:42719852 PPHLN1;ZCRB1 0.61 7.5 0.38 6.08e-13 Coronary artery disease; CRC cis rs10927875 0.541 rs1763601 chr1:16340460 G/T cg24140574 chr1:16342155 HSPB7 0.47 6.67 0.34 1.12e-10 Dilated cardiomyopathy; CRC cis rs1656402 1.000 rs1729251 chr2:233428518 G/A cg03852847 chr2:233439513 NA 0.44 7.56 0.38 4.08e-13 Non-small cell lung cancer (survival); CRC cis rs990171 1.000 rs2160232 chr2:103046880 G/A cg03938978 chr2:103052716 IL18RAP 0.46 5.82 0.31 1.41e-8 Lymphocyte counts; CRC cis rs4664293 0.836 rs10190704 chr2:160594962 G/A cg08347373 chr2:160653686 CD302 -0.46 -7.31 -0.37 2.02e-12 Monocyte percentage of white cells; CRC cis rs3219474 0.614 rs114562368 chr1:45899178 G/A cg06784218 chr1:46089804 CCDC17 0.64 6.41 0.33 5.15e-10 Peripheral arterial disease (traffic-related air pollution interaction); CRC trans rs8123881 0.733 rs7268466 chr20:15810676 C/T cg12946690 chr17:2206740 SMG6;SRR 0.57 6.52 0.34 2.66e-10 Body mass index; CRC cis rs9488822 0.676 rs12524249 chr6:116368813 G/A cg15226275 chr6:116381976 FRK 0.29 8.35 0.42 1.9e-15 Cholesterol, total;LDL cholesterol; CRC cis rs898097 0.625 rs898095 chr17:80890638 T/C cg10494973 chr17:80897199 TBCD -0.36 -5.63 -0.3 3.87e-8 Breast cancer; CRC cis rs208515 0.525 rs10944863 chr6:66676238 C/T cg07460842 chr6:66804631 NA 0.92 11.59 0.54 2.7e-26 Exhaled nitric oxide levels; CRC cis rs847649 0.699 rs7794668 chr7:102510416 C/T cg18108683 chr7:102477205 FBXL13 0.63 11.04 0.52 2.5e-24 Morning vs. evening chronotype; CRC cis rs2880765 0.835 rs12708553 chr15:86046833 C/G cg17133734 chr15:86042851 AKAP13 -0.44 -7.13 -0.37 6.5e-12 Coronary artery disease; CRC cis rs9457247 1.000 rs404222 chr6:167402150 G/A cg23791538 chr6:167370224 RNASET2 -0.36 -5.73 -0.3 2.32e-8 Crohn's disease; CRC cis rs6570726 0.935 rs382910 chr6:145865941 G/A cg05347473 chr6:146136440 FBXO30 0.4 6.29 0.33 9.84e-10 Lobe attachment (rater-scored or self-reported); CRC cis rs11190604 1.000 rs7100386 chr10:102301417 C/T cg16342193 chr10:102329863 NA -0.36 -5.99 -0.31 5.62e-9 Palmitoleic acid (16:1n-7) levels; CRC cis rs35110281 0.782 rs1454651 chr21:45012476 A/G cg01579765 chr21:45077557 HSF2BP -0.41 -7.58 -0.39 3.62e-13 Mean corpuscular volume; CRC cis rs10504229 0.906 rs58559296 chr8:58171714 T/C cg01721255 chr8:58191610 C8orf71 0.49 6.17 0.32 2e-9 Developmental language disorder (linguistic errors); CRC cis rs728616 0.717 rs12415523 chr10:81691976 T/C cg05935833 chr10:81318306 SFTPA2 -0.72 -8.19 -0.41 5.66e-15 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs172166 0.694 rs1225716 chr6:28113746 A/C cg02683197 chr6:28174875 NA 0.7 9.74 0.47 7.45e-20 Cardiac Troponin-T levels; CRC cis rs68170813 0.559 rs12537342 chr7:106943563 T/C cg02696742 chr7:106810147 HBP1 -0.57 -6.26 -0.33 1.18e-9 Coronary artery disease; CRC cis rs6500395 0.962 rs7499213 chr16:48680597 T/C cg04672837 chr16:48644449 N4BP1 0.42 6.02 0.31 4.71e-9 Response to tocilizumab in rheumatoid arthritis; CRC cis rs7945705 0.935 rs10769971 chr11:8925276 C/T cg12365402 chr11:9010492 NRIP3 0.5 8.04 0.41 1.62e-14 Hemoglobin concentration; CRC cis rs9287719 0.967 rs2287062 chr2:10743191 G/A cg00105475 chr2:10696890 NA 0.45 7.3 0.37 2.19e-12 Prostate cancer; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg07252851 chr5:74063056 GFM2;NSA2 0.41 6.53 0.34 2.55e-10 Liver disease severity in Alagille syndrome; CRC cis rs2243480 0.908 rs1532573 chr7:65798802 A/G cg18252515 chr7:66147081 NA 1.28 14.93 0.64 7.56e-39 Diabetic kidney disease; CRC cis rs992157 1.000 rs13429408 chr2:219142860 C/A cg00012203 chr2:219082015 ARPC2 0.51 8.5 0.42 6.57e-16 Colorectal cancer; CRC cis rs7119 0.679 rs12902698 chr15:77809010 A/C cg27398640 chr15:77910606 LINGO1 -0.43 -7.35 -0.38 1.55e-12 Type 2 diabetes; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg07767672 chr17:1420129 INPP5K;LOC100306951 0.45 6.2 0.32 1.64e-9 Anxiety disorder; CRC cis rs7666738 0.830 rs11727653 chr4:99001774 T/C cg05340658 chr4:99064831 C4orf37 0.61 9.54 0.47 3.44e-19 Colonoscopy-negative controls vs population controls; CRC cis rs7542091 0.635 rs7550733 chr1:210044968 G/A cg05527609 chr1:210001259 C1orf107 -0.44 -5.86 -0.31 1.15e-8 Monobrow; CRC cis rs9649213 0.555 rs6968193 chr7:97915902 C/T cg24562669 chr7:97807699 LMTK2 0.45 7.54 0.38 4.56e-13 Prostate cancer (SNP x SNP interaction); CRC cis rs6723226 0.806 rs2249109 chr2:32750879 G/A cg02381751 chr2:32503542 YIPF4 0.56 8.06 0.41 1.43e-14 Intelligence (multi-trait analysis); CRC cis rs9517320 0.515 rs9556969 chr13:99195948 T/C cg20487152 chr13:99095054 FARP1 -0.44 -6.47 -0.34 3.55e-10 Longevity; CRC trans rs3780486 0.881 rs10738906 chr9:33135634 T/C cg04842962 chr6:43655489 MRPS18A 1.15 23.86 0.8 9.57e-74 IgG glycosylation; CRC cis rs11098499 0.743 rs10003567 chr4:120241674 C/T cg09307838 chr4:120376055 NA 0.62 9.71 0.47 9.4e-20 Corneal astigmatism; CRC cis rs10411161 0.702 rs7250193 chr19:52385520 C/T cg22331349 chr19:52391350 ZNF577 -0.45 -5.84 -0.31 1.26e-8 Breast cancer; CRC cis rs7617773 0.746 rs4371540 chr3:48353543 G/A cg11946769 chr3:48343235 NME6 0.75 9.94 0.48 1.59e-20 Coronary artery disease; CRC cis rs7917772 0.582 rs12784963 chr10:104336986 G/A cg11453585 chr10:104263688 ACTR1A;SUFU -0.83 -14.97 -0.64 5.28e-39 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC cis rs1387259 0.931 rs11168474 chr12:48621384 A/C cg21466736 chr12:48725269 NA -0.53 -7.88 -0.4 4.71e-14 Obstructive sleep apnea trait (apnea hypopnea index); CRC cis rs10504229 0.683 rs34859456 chr8:58117722 A/C cg22535103 chr8:58192502 C8orf71 -0.7 -9.34 -0.46 1.47e-18 Developmental language disorder (linguistic errors); CRC trans rs2303319 0.504 rs56100249 chr2:162415157 T/C cg04269497 chr6:167369491 RNASET2 -0.75 -6.05 -0.32 3.91e-9 Cognitive function; CRC cis rs7680126 0.633 rs11727390 chr4:10296760 C/T cg00071950 chr4:10020882 SLC2A9 -0.47 -6.09 -0.32 3.11e-9 Urate levels in lean individuals;Urate levels in overweight individuals;Urate levels in obese individuals; CRC cis rs7927771 1.000 rs2290850 chr11:47807774 T/C cg20307385 chr11:47447363 PSMC3 -0.5 -6.58 -0.34 1.83e-10 Subjective well-being; CRC cis rs769267 0.965 rs4808938 chr19:19401218 G/A cg17414380 chr19:19431394 KIAA0892;SF4 0.41 5.64 0.3 3.59e-8 Tonsillectomy; CRC cis rs11098499 0.913 rs56122576 chr4:120129336 A/G cg24375607 chr4:120327624 NA 0.49 7.58 0.39 3.5e-13 Corneal astigmatism; CRC cis rs7937682 0.855 rs527078 chr11:111479713 T/C cg09085632 chr11:111637200 PPP2R1B -0.98 -19.2 -0.73 1.2e-55 Primary sclerosing cholangitis; CRC cis rs2742417 0.967 rs9825559 chr3:45740278 T/C cg04837898 chr3:45731254 SACM1L -0.36 -5.87 -0.31 1.09e-8 Response to anti-depressant treatment in major depressive disorder; CRC cis rs2811415 0.597 rs11708842 chr3:127790625 T/C cg13719885 chr3:127795394 NA -0.39 -5.95 -0.31 6.69e-9 Lung function (FEV1/FVC); CRC cis rs6960043 0.738 rs10950549 chr7:15057829 G/A cg19272540 chr7:15055459 NA 0.25 6.83 0.35 4.13e-11 Type 2 diabetes; CRC cis rs775227 1.000 rs13094203 chr3:112993367 G/A cg18753928 chr3:113234510 CCDC52 -0.45 -5.63 -0.3 3.91e-8 Dental caries; CRC cis rs7845219 0.544 rs7015841 chr8:95920193 A/C cg16049864 chr8:95962084 TP53INP1 -0.44 -6.77 -0.35 5.88e-11 Type 2 diabetes; CRC cis rs9894429 1.000 rs9894429 chr17:79596811 C/T cg21984481 chr17:79567631 NPLOC4 -0.53 -9.8 -0.48 4.71e-20 Eye color traits; CRC cis rs4332037 0.539 rs868754 chr7:2033780 G/C cg02825527 chr7:2087843 MAD1L1 -0.53 -6.02 -0.32 4.62e-9 Bipolar disorder; CRC trans rs1814175 0.645 rs1851849 chr11:50012164 G/A cg03929089 chr4:120376271 NA -0.88 -15.51 -0.65 4.26e-41 Height; CRC cis rs11098499 0.863 rs3775841 chr4:120425777 A/C cg09307838 chr4:120376055 NA 0.69 10.48 0.5 2.36e-22 Corneal astigmatism; CRC cis rs4290604 0.748 rs4663241 chr2:238085960 T/C cg23555395 chr2:238036564 NA -0.6 -6.07 -0.32 3.57e-9 Asthma; CRC cis rs3736594 0.879 rs77154381 chr2:27982119 A/G cg27432699 chr2:27873401 GPN1 0.59 7.79 0.39 9.04e-14 Fasting blood glucose;Fasting blood glucose (BMI interaction); CRC cis rs4604732 0.631 rs10754561 chr1:247622800 A/G cg02104434 chr1:247694406 LOC148824;OR2C3 0.53 8.48 0.42 7.77e-16 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CRC cis rs1348850 0.914 rs12104588 chr2:178253675 G/A cg22681709 chr2:178499509 PDE11A -0.37 -6.91 -0.36 2.59e-11 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs6952808 0.825 rs34296663 chr7:1935245 C/T cg22963979 chr7:1858916 MAD1L1 -0.49 -7.35 -0.38 1.54e-12 Bipolar disorder and schizophrenia; CRC cis rs7216064 0.953 rs12450907 chr17:65870644 T/G cg12091567 chr17:66097778 LOC651250 -0.67 -7.79 -0.39 8.84e-14 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CRC trans rs61931739 0.517 rs56308002 chr12:34016021 C/G cg26384229 chr12:38710491 ALG10B 0.54 6.9 0.36 2.76e-11 Morning vs. evening chronotype; CRC cis rs597539 0.652 rs1249474 chr11:68654774 C/T cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.79 13.32 0.59 1.16e-32 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs6728642 0.803 rs11891457 chr2:97632449 G/T cg26665480 chr2:98280029 ACTR1B -0.5 -5.87 -0.31 1.08e-8 Bipolar disorder lithium response (continuous) or schizophrenia; CRC cis rs9649213 0.593 rs13307593 chr7:97986146 A/G cg00277769 chr7:97922759 BAIAP2L1 -0.6 -10.46 -0.5 2.68e-22 Prostate cancer (SNP x SNP interaction); CRC cis rs4423214 1.000 rs2276361 chr11:71169648 A/G cg05163923 chr11:71159392 DHCR7 0.67 9.35 0.46 1.41e-18 Vitamin D levels; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg11595794 chr4:186317094 ANKRD37 0.41 6.23 0.32 1.4e-9 Intelligence (multi-trait analysis); CRC trans rs8002861 0.905 rs11617551 chr13:44443977 T/C cg12856521 chr11:46389249 DGKZ -0.42 -6.8 -0.35 5.03e-11 Leprosy; CRC cis rs8180040 0.805 rs17410853 chr3:47363971 G/T cg02527881 chr3:46936655 PTH1R 0.33 5.84 0.31 1.23e-8 Colorectal cancer; CRC cis rs9902453 0.791 rs7219163 chr17:28210703 A/C cg26525008 chr17:28256777 EFCAB5;SSH2 0.66 10.58 0.5 1.03e-22 Coffee consumption (cups per day); CRC cis rs2932538 0.922 rs2932535 chr1:113201412 G/C cg22162597 chr1:113214053 CAPZA1 -0.68 -9.71 -0.47 8.86e-20 Systolic blood pressure;Diastolic blood pressure;Hypertension;Blood pressure; CRC cis rs7914558 0.966 rs10786719 chr10:104637992 C/T cg04362960 chr10:104952993 NT5C2 -0.57 -8.54 -0.43 4.96e-16 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs6952808 0.771 rs10950415 chr7:1914477 A/G cg23102388 chr7:1867652 MAD1L1 -0.32 -5.98 -0.31 5.69e-9 Bipolar disorder and schizophrenia; CRC cis rs854765 0.547 rs4584886 chr17:17896205 C/T cg04398451 chr17:18023971 MYO15A -0.61 -11.76 -0.54 6.8e-27 Total body bone mineral density; CRC cis rs2033908 0.620 rs1371753 chr11:12853703 G/A cg25843174 chr11:12811716 TEAD1 -0.42 -7.49 -0.38 6.56e-13 Sitting height ratio; CRC cis rs7618915 0.547 rs34610142 chr3:52708429 G/A cg11645453 chr3:52864694 ITIH4 0.37 6.41 0.33 4.91e-10 Bipolar disorder; CRC cis rs9527 0.590 rs1807298 chr10:104870218 G/A cg04362960 chr10:104952993 NT5C2 0.61 8.46 0.42 8.85e-16 Arsenic metabolism; CRC cis rs8072100 0.875 rs62073966 chr17:45600013 T/A cg25173405 chr17:45401733 C17orf57 0.47 7.15 0.37 5.6e-12 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs116095464 0.558 rs55776650 chr5:273826 G/A cg22496380 chr5:211416 CCDC127 -0.9 -10.29 -0.49 1.07e-21 Breast cancer; CRC cis rs12541635 0.801 rs9642802 chr8:107101364 A/T cg10147462 chr8:107024639 NA -0.39 -5.93 -0.31 7.65e-9 Age of smoking initiation; CRC cis rs17125944 0.505 rs76219229 chr14:53178346 G/A cg00686598 chr14:53173677 PSMC6 1.01 9.44 0.46 7.17e-19 Alzheimer's disease (late onset); CRC cis rs9368481 0.761 rs9357028 chr6:26967224 T/G cg18867708 chr6:26865862 GUSBL1 -0.41 -5.72 -0.3 2.34e-8 Autism spectrum disorder or schizophrenia; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg19774699 chr22:31688639 PIK3IP1 0.42 6.23 0.32 1.45e-9 Intelligence (multi-trait analysis); CRC cis rs780096 0.565 rs10169261 chr2:27727314 C/T cg12648201 chr2:27665141 KRTCAP3 -0.3 -5.94 -0.31 7.09e-9 Total body bone mineral density; CRC cis rs9549367 0.789 rs71446679 chr13:113894821 C/T cg00898013 chr13:113819073 PROZ -0.45 -6.37 -0.33 6.54e-10 Platelet distribution width; CRC cis rs2859741 1.000 rs1773575 chr1:37505129 T/C cg09363841 chr1:37513479 NA -0.63 -11.81 -0.55 4.37e-27 Forced expiratory volume in 1 second (environmental tobacco smoke interaction); CRC cis rs875971 0.862 rs4236208 chr7:65749078 C/T cg11764359 chr7:65958608 NA -0.6 -9.34 -0.46 1.49e-18 Aortic root size; CRC cis rs2249625 0.523 rs2496552 chr6:72853042 T/C cg18830697 chr6:72922368 RIMS1 -0.31 -6.25 -0.33 1.3e-9 Acute urticaria and angioedema (non-steroidal anti-inflammatory drug-induced); CRC trans rs7267979 0.844 rs6083851 chr20:25401235 G/A cg17903999 chr18:56338584 MALT1 0.41 6.64 0.34 1.26e-10 Liver enzyme levels (alkaline phosphatase); CRC cis rs6964587 0.967 rs6465340 chr7:91588664 G/A cg17063962 chr7:91808500 NA 0.8 14.05 0.61 1.92e-35 Breast cancer; CRC cis rs4400599 0.572 rs7516809 chr1:154205501 T/C cg26808167 chr1:154192205 UBAP2L;C1orf43 -0.36 -5.71 -0.3 2.49e-8 Platelet distribution width; CRC cis rs10870270 1.000 rs7199 chr10:133769848 C/G cg17892150 chr10:133769511 PPP2R2D -0.74 -10.97 -0.52 4.45e-24 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; CRC cis rs9611565 0.879 rs4820437 chr22:41761290 T/C cg06634786 chr22:41940651 POLR3H -0.47 -6.21 -0.32 1.56e-9 Vitiligo; CRC cis rs2235544 0.579 rs1537323 chr1:54482523 G/T cg25741118 chr1:54482237 LDLRAD1 0.22 6.29 0.33 1.03e-9 Multiple myeloma (hyperdiploidy);Thyroid hormone levels; CRC cis rs7131987 0.650 rs7311912 chr12:29475703 G/C cg09582351 chr12:29534625 ERGIC2 -0.34 -7.19 -0.37 4.36e-12 QT interval; CRC cis rs6461049 0.800 rs3800909 chr7:2159594 C/G cg04267008 chr7:1944627 MAD1L1 -0.48 -6.84 -0.35 3.84e-11 Schizophrenia; CRC cis rs6429082 0.791 rs291394 chr1:235651682 A/G cg26050004 chr1:235667680 B3GALNT2 0.59 8.1 0.41 1.11e-14 Adiposity; CRC trans rs72766638 0.895 rs72766630 chr9:136926791 G/T cg09836344 chr4:1243392 C4orf42;CTBP1 -0.58 -6.28 -0.33 1.05e-9 Mosquito bite size; CRC cis rs2227564 0.729 rs2675674 chr10:75652682 G/A cg00564723 chr10:75632066 CAMK2G -0.33 -7.58 -0.39 3.47e-13 Crohn's disease;Inflammatory bowel disease; CRC cis rs7715806 0.500 rs72633984 chr5:75005899 A/G cg19683494 chr5:74908142 NA 0.51 5.76 0.3 1.89e-8 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs1552244 0.882 rs55962400 chr3:10044457 C/T cg08888203 chr3:10149979 C3orf24 0.59 7.37 0.38 1.38e-12 Alzheimer's disease; CRC cis rs877282 0.583 rs112372193 chr10:826602 A/G cg17470449 chr10:769945 NA 0.5 6.97 0.36 1.78e-11 Uric acid levels; CRC cis rs7618915 0.571 rs6778844 chr3:52596398 C/T cg05573699 chr3:52720067 GNL3;PBRM1 0.45 6.31 0.33 9.06e-10 Bipolar disorder; CRC cis rs9527 0.590 rs2281877 chr10:104866062 C/T cg04362960 chr10:104952993 NT5C2 0.6 8.41 0.42 1.23e-15 Arsenic metabolism; CRC cis rs1451375 0.617 rs11772714 chr7:50542843 G/A cg14593290 chr7:50529359 DDC -0.61 -8.02 -0.4 1.82e-14 Malaria; CRC cis rs995000 0.931 rs11207997 chr1:63061906 C/T cg19896129 chr1:63156450 NA 0.41 6.12 0.32 2.63e-9 Triglyceride levels; CRC cis rs4746818 1.000 rs906217 chr10:70954661 T/C cg11621586 chr10:70884670 VPS26A 0.9 7.84 0.4 6.14e-14 Left atrial antero-posterior diameter; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg20573919 chr11:8710810 RPL27A 0.42 6.27 0.33 1.11e-9 Intelligence (multi-trait analysis); CRC cis rs3768617 0.510 rs2296290 chr1:183079412 C/T ch.1.3577855R chr1:183094577 LAMC1 0.88 15.62 0.65 1.5e-41 Fuchs's corneal dystrophy; CRC cis rs1580019 0.587 rs6968990 chr7:32552159 C/T cg14728415 chr7:32535168 LSM5;AVL9 -0.43 -6.35 -0.33 6.96e-10 Cognitive ability; CRC cis rs11971779 0.616 rs6467836 chr7:139023517 C/G cg07862535 chr7:139043722 LUC7L2 0.56 7.3 0.37 2.21e-12 Diisocyanate-induced asthma; CRC cis rs79387448 0.745 rs6709719 chr2:103144953 G/A cg00507830 chr2:103233733 NA 0.52 5.78 0.3 1.7e-8 Gut microbiota (bacterial taxa); CRC cis rs1539053 0.932 rs7544337 chr1:58108645 T/C cg23710611 chr1:58098908 DAB1 0.35 5.67 0.3 3.16e-8 Plasma omega-6 polyunsaturated fatty acid levels (arachidonic acid); CRC cis rs875971 1.000 rs6961155 chr7:65933295 T/C cg11764359 chr7:65958608 NA 0.62 9.91 0.48 1.96e-20 Aortic root size; CRC cis rs875971 0.862 rs1083554 chr7:65852341 T/C cg11764359 chr7:65958608 NA 0.57 8.44 0.42 1.01e-15 Aortic root size; CRC cis rs11971779 0.680 rs7783619 chr7:139061437 G/A cg23387468 chr7:139079360 LUC7L2 0.41 7.09 0.36 8.15e-12 Diisocyanate-induced asthma; CRC trans rs17685 0.712 rs1639620 chr7:75704090 A/G cg19862616 chr7:65841803 NCRNA00174 0.99 18.51 0.71 6.2e-53 Coffee consumption;Coffee consumption (cups per day); CRC trans rs11764590 0.715 rs11766468 chr7:2082604 G/A cg11693508 chr17:37793320 STARD3 0.57 6.61 0.34 1.58e-10 Neuroticism; CRC cis rs7259376 1.000 rs11668269 chr19:22513960 G/A cg02657401 chr19:22469223 NA -0.39 -8.66 -0.43 2.18e-16 Menopause (age at onset); CRC cis rs8062405 0.723 rs4788077 chr16:28569764 G/C cg16576597 chr16:28551801 NUPR1 0.5 6.76 0.35 6.29e-11 Cognitive ability (multi-trait analysis);Cognitive ability; CRC cis rs2717559 0.522 rs10956987 chr8:143886613 T/C cg20041105 chr8:143859282 LYNX1 -0.71 -13.39 -0.59 6.18e-33 Urinary tract infection frequency; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg20505218 chr17:80009845 GPS1;RFNG 0.45 6.55 0.34 2.2e-10 Intelligence (multi-trait analysis); CRC cis rs853679 1.000 rs68141011 chr6:28217797 G/T cg15786705 chr6:28176104 NA 0.63 6.06 0.32 3.78e-9 Depression; CRC cis rs883565 0.606 rs7650682 chr3:39079418 C/A cg01426195 chr3:39028469 NA -0.47 -7.95 -0.4 3.02e-14 Handedness; CRC cis rs881375 0.678 rs2416804 chr9:123676396 C/G cg09419670 chr9:123605666 PSMD5;LOC253039 -0.48 -7.59 -0.39 3.4e-13 Rheumatoid arthritis; CRC cis rs2224391 1.000 rs13191012 chr6:5261292 G/A cg09085698 chr6:5261316 LYRM4;FARS2 -0.44 -5.74 -0.3 2.1e-8 Height; CRC cis rs7945705 0.902 rs10769979 chr11:9010659 C/T cg00186954 chr11:8933980 ST5;C11orf17 0.41 6.42 0.33 4.67e-10 Hemoglobin concentration; CRC cis rs921968 0.541 rs664514 chr2:219329819 A/G cg02176678 chr2:219576539 TTLL4 0.54 8.69 0.43 1.78e-16 Mean corpuscular hemoglobin concentration; CRC cis rs3768617 0.510 rs6424885 chr1:183066254 T/G ch.1.3577855R chr1:183094577 LAMC1 0.86 15.19 0.64 7.31e-40 Fuchs's corneal dystrophy; CRC cis rs9916302 0.660 rs4795379 chr17:37674683 T/G cg20243544 chr17:37824526 PNMT 0.47 5.6 0.3 4.45e-8 Glomerular filtration rate (creatinine); CRC cis rs2549003 0.966 rs839 chr5:131819126 C/T cg00255919 chr5:131827918 IRF1 0.59 11.92 0.55 1.77e-27 Asthma (sex interaction); CRC cis rs6840360 0.593 rs6847844 chr4:152693246 C/T cg09659197 chr4:152720779 NA 0.41 8.5 0.42 6.5e-16 Intelligence (multi-trait analysis); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg11928684 chr11:47291227 MADD 0.41 6.19 0.32 1.75e-9 Intelligence (multi-trait analysis); CRC cis rs644799 0.710 rs666398 chr11:95551136 C/T cg25478527 chr11:95522999 CEP57;FAM76B 0.48 7.52 0.38 5.35e-13 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs6546550 0.935 rs10865380 chr2:70091246 T/C cg02498382 chr2:70120550 SNRNP27 -0.42 -6.9 -0.36 2.67e-11 Prevalent atrial fibrillation; CRC cis rs11758351 1.000 rs79264785 chr6:26194121 C/T cg22723502 chr6:26240528 HIST1H4F -0.38 -5.83 -0.31 1.35e-8 Gout;Renal underexcretion gout; CRC cis rs4713118 0.868 rs2893928 chr6:27738430 C/A cg06470822 chr6:28175283 NA 0.88 9.76 0.47 6.43e-20 Parkinson's disease; CRC cis rs477692 0.905 rs576560 chr10:131420697 C/A cg05714579 chr10:131428358 MGMT 0.6 8.64 0.43 2.54e-16 Response to temozolomide; CRC cis rs8044868 0.530 rs12932845 chr16:72122765 G/A cg23815491 chr16:72088622 HP 0.47 6.83 0.35 4.09e-11 Body mass index (change over time) in cancer or chronic obstructive pulmonary disease;Body mass index (change over time) in cancer; CRC cis rs10479542 0.784 rs6896940 chr5:178985994 G/C cg14820908 chr5:178986412 RUFY1 0.39 6.81 0.35 4.54e-11 Lung cancer; CRC cis rs11608355 0.545 rs12822891 chr12:109896002 A/G cg05360138 chr12:110035743 NA 0.76 8.56 0.43 4.51e-16 Neuroticism; CRC cis rs2982552 0.787 rs11155810 chr6:152056081 T/C cg22157087 chr6:152012887 ESR1 0.37 5.66 0.3 3.31e-8 Bone properties (heel); CRC cis rs11583043 0.708 rs874905 chr1:101539702 G/A cg16556008 chr1:101360663 SLC30A7;EXTL2 0.45 5.71 0.3 2.49e-8 Ulcerative colitis;Inflammatory bowel disease; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg11190155 chr3:9975447 CRELD1 0.51 7.31 0.37 2.03e-12 Response to antipsychotic treatment; CRC cis rs73200209 0.703 rs57060349 chr12:116579304 T/C cg01776926 chr12:116560359 MED13L -0.63 -7.35 -0.38 1.6e-12 Total body bone mineral density; CRC cis rs10078 0.528 rs2434697 chr5:466811 T/C cg26072250 chr5:443457 EXOC3;C5orf55 0.58 5.79 0.3 1.64e-8 Fat distribution (HIV); CRC cis rs1552244 1.000 rs1552244 chr3:10135577 A/G cg10729496 chr3:10149963 C3orf24 0.49 6.56 0.34 2.14e-10 Alzheimer's disease; CRC cis rs3749237 1.000 rs4768 chr3:49758764 A/G cg24308560 chr3:49941425 MST1R -0.42 -5.99 -0.31 5.64e-9 Resting heart rate; CRC cis rs910316 0.967 rs175498 chr14:75536369 G/A cg11812906 chr14:75593930 NEK9 -0.61 -9.67 -0.47 1.24e-19 Height; CRC cis rs7220401 0.789 rs4794859 chr17:27962393 A/C cg26525008 chr17:28256777 EFCAB5;SSH2 -0.53 -8.06 -0.41 1.42e-14 Coronary artery disease; CRC cis rs12325245 0.536 rs3169293 chr16:58552959 A/G cg01472538 chr16:58549086 SETD6 1.1 7.19 0.37 4.4e-12 Schizophrenia; CRC cis rs7107174 1.000 rs55761949 chr11:77993860 A/G cg02023728 chr11:77925099 USP35 0.53 8.09 0.41 1.15e-14 Testicular germ cell tumor; CRC cis rs780096 0.526 rs1647267 chr2:27651054 A/T cg22903471 chr2:27725779 GCKR -0.36 -5.9 -0.31 9.13e-9 Total body bone mineral density; CRC cis rs1267303 0.642 rs61783087 chr1:46999955 T/C cg08533674 chr1:46993347 NA -0.81 -10.42 -0.5 3.8e-22 Monobrow; CRC cis rs6951245 0.935 rs118132455 chr7:1068232 C/A cg04025307 chr7:1156635 C7orf50 0.63 6.63 0.34 1.41e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs6701037 0.748 rs2685 chr1:175127771 A/G cg00321850 chr1:175162397 KIAA0040 0.41 6.88 0.35 3.1e-11 Alcohol dependence; CRC cis rs832540 0.931 rs33318 chr5:56208414 G/T cg20203395 chr5:56204925 C5orf35 -0.41 -5.74 -0.3 2.19e-8 Coronary artery disease; CRC cis rs2742540 0.524 rs2653562 chr11:8918160 A/T cg21881798 chr11:8931708 C11orf17;ST5 -0.5 -7.63 -0.39 2.48e-13 Hematocrit; CRC trans rs1814175 0.817 rs7946556 chr11:49944874 G/A cg11707556 chr5:10655725 ANKRD33B -0.42 -7.98 -0.4 2.5e-14 Height; CRC cis rs7845219 0.544 rs34293080 chr8:95908078 G/T cg16049864 chr8:95962084 TP53INP1 -0.43 -6.57 -0.34 1.93e-10 Type 2 diabetes; CRC cis rs7772486 0.686 rs9497396 chr6:146014963 C/A cg13319975 chr6:146136371 FBXO30 0.42 6.28 0.33 1.06e-9 Lobe attachment (rater-scored or self-reported); CRC trans rs10982213 0.830 rs2274163 chr9:117188714 C/T cg08925066 chr14:39572669 SEC23A 0.37 6.12 0.32 2.68e-9 Interleukin-6 levels; CRC cis rs208520 1.000 rs12200490 chr6:66976084 G/A cg07460842 chr6:66804631 NA 0.92 11.4 0.53 1.31e-25 Exhaled nitric oxide output; CRC cis rs6960043 0.818 rs10487796 chr7:15063430 T/A cg19272540 chr7:15055459 NA 0.23 6.16 0.32 2.12e-9 Type 2 diabetes; CRC trans rs1814175 0.645 rs28445479 chr11:50047999 A/G cg03929089 chr4:120376271 NA -0.89 -15.95 -0.66 7.68e-43 Height; CRC cis rs6762 0.748 rs1130719 chr11:838760 T/A cg07691484 chr11:842764 TSPAN4;POLR2L -0.56 -8.27 -0.41 3.41e-15 Mean platelet volume; CRC trans rs1569175 0.850 rs3106088 chr2:200907393 A/C cg12143499 chr12:27615389 NA 0.68 6.15 0.32 2.25e-9 Response to treatment for acute lymphoblastic leukemia; CRC cis rs4144743 0.941 rs10438782 chr17:45323892 G/A cg18085866 chr17:45331354 ITGB3 -0.59 -8.11 -0.41 1.02e-14 Body mass index; CRC cis rs9733 0.596 rs6681990 chr1:150695929 A/G cg10589385 chr1:150898437 SETDB1 0.28 5.96 0.31 6.66e-9 Tonsillectomy; CRC cis rs35146811 0.622 rs6946204 chr7:99589125 T/C cg13334819 chr7:99746414 C7orf59 -0.44 -6.0 -0.31 5.32e-9 Coronary artery disease; CRC cis rs7618915 0.547 rs34610142 chr3:52708429 G/A cg05573699 chr3:52720067 GNL3;PBRM1 -0.45 -6.32 -0.33 8.47e-10 Bipolar disorder; CRC cis rs992157 0.710 rs7569907 chr2:219070551 C/T cg00012203 chr2:219082015 ARPC2 0.62 10.39 0.5 4.69e-22 Colorectal cancer; CRC cis rs7552404 0.824 rs1251079 chr1:76189445 C/T cg10523679 chr1:76189770 ACADM 0.92 16.72 0.68 7.27e-46 Blood metabolite levels;Acylcarnitine levels; CRC cis rs6831352 0.879 rs2602879 chr4:100040652 G/A cg12011299 chr4:100065546 ADH4 0.49 9.26 0.45 2.63e-18 Alcohol dependence; CRC cis rs16852403 0.619 rs2862317 chr1:178146278 A/T cg00404053 chr1:178313656 RASAL2 0.6 7.63 0.39 2.6e-13 Childhood ear infection; CRC cis rs7246657 0.943 rs9917081 chr19:37876616 T/C cg23950597 chr19:37808831 NA -0.52 -6.28 -0.33 1.09e-9 Coronary artery calcification; CRC cis rs13191362 1.000 rs67840803 chr6:163049048 C/T cg23758597 chr6:163146217 PARK2 -0.66 -6.6 -0.34 1.69e-10 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs7914558 0.966 rs10786721 chr10:104654383 C/A cg04362960 chr10:104952993 NT5C2 0.59 8.93 0.44 3.13e-17 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs1532331 0.833 rs10058350 chr5:43141644 T/C cg09164108 chr5:43007320 NA 0.38 5.8 0.3 1.58e-8 Menarche (age at onset); CRC cis rs2749592 0.918 rs1208653 chr10:38253826 C/G cg00409905 chr10:38381863 ZNF37A 0.5 7.04 0.36 1.16e-11 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs9733 0.596 rs6685702 chr1:150656307 A/G cg10589385 chr1:150898437 SETDB1 0.28 5.98 0.31 5.86e-9 Tonsillectomy; CRC cis rs4689592 0.587 rs6825954 chr4:7074226 T/C cg26116260 chr4:7069785 GRPEL1 0.95 13.82 0.61 1.4e-34 Monocyte percentage of white cells; CRC cis rs8017423 0.630 rs4904678 chr14:90821670 T/C cg14092571 chr14:90743983 NA 0.39 5.97 0.31 6.31e-9 Mortality in heart failure; CRC cis rs75920871 0.588 rs10892055 chr11:116868371 G/A cg20608306 chr11:116969690 SIK3 -0.32 -5.94 -0.31 7.18e-9 Subjective well-being; CRC cis rs4953076 0.573 rs67537903 chr2:44422111 G/A cg04920474 chr2:44395004 PPM1B 0.57 7.59 0.39 3.3e-13 Height; CRC cis rs78545713 0.536 rs80202565 chr6:26233882 C/G cg01420254 chr6:26195488 NA 0.74 6.28 0.33 1.07e-9 Iron status biomarkers (total iron binding capacity); CRC cis rs2495707 0.647 rs1541266 chr10:102421292 C/T cg24024056 chr10:102415556 NA -0.36 -7.16 -0.37 5.37e-12 Body mass index; CRC cis rs853679 0.517 rs17711801 chr6:28092307 C/G cg06470822 chr6:28175283 NA 1.0 13.33 0.59 1.06e-32 Depression; CRC trans rs61931739 0.500 rs56056630 chr12:34543465 T/C cg26384229 chr12:38710491 ALG10B 0.59 8.77 0.44 9.64e-17 Morning vs. evening chronotype; CRC cis rs7246657 0.943 rs713256 chr19:37865365 C/T cg23950597 chr19:37808831 NA -0.54 -6.51 -0.34 2.79e-10 Coronary artery calcification; CRC cis rs9611565 0.729 rs2413647 chr22:41907148 G/A cg03806693 chr22:41940476 POLR3H -1.14 -15.14 -0.64 1.16e-39 Vitiligo; CRC cis rs758324 0.947 rs72793242 chr5:131242506 A/T cg06307176 chr5:131281290 NA -0.44 -6.38 -0.33 6.05e-10 Alzheimer's disease in APOE e4- carriers; CRC cis rs1218582 0.772 rs10796934 chr1:154849479 C/G cg16680214 chr1:154839983 KCNN3 -0.49 -9.84 -0.48 3.46e-20 Prostate cancer; CRC trans rs2324229 0.797 rs1180237 chr6:83943928 A/C cg14681854 chr1:93250590 EVI5 -0.42 -6.02 -0.31 4.68e-9 Platelet-derived growth factor BB levels; CRC cis rs6908034 0.660 rs7750716 chr6:19804839 C/T cg02682789 chr6:19804855 NA 0.79 7.64 0.39 2.36e-13 Endometriosis;Deep ovarian and/or rectovaginal disease with dense adhesions; CRC cis rs7937682 1.000 rs7128353 chr11:111538875 A/G cg19812747 chr11:111475976 SIK2 -0.55 -9.27 -0.46 2.44e-18 Primary sclerosing cholangitis; CRC cis rs9467711 0.651 rs71557316 chr6:26072981 G/A cg19084075 chr6:26124329 HIST1H2AC;HIST1H2BC 0.74 6.49 0.34 3.09e-10 Autism spectrum disorder or schizophrenia; CRC cis rs447 0.895 rs12707616 chr7:83745440 C/T cg22846510 chr7:83753280 SEMA3A -0.41 -5.7 -0.3 2.65e-8 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs3008870 0.755 rs3929738 chr1:67397865 T/C cg08660285 chr1:67390436 MIER1;WDR78 0.55 7.73 0.39 1.34e-13 Lymphocyte percentage of white cells; CRC cis rs4713118 0.516 rs6931858 chr6:28078411 A/T cg25164649 chr6:28176230 NA 0.71 8.6 0.43 3.2e-16 Parkinson's disease; CRC cis rs425277 0.606 rs377283 chr1:2075570 T/C cg04315214 chr1:2043799 PRKCZ -0.39 -6.64 -0.34 1.33e-10 Height; CRC cis rs9858542 0.537 rs115753735 chr3:49355005 T/C cg00383909 chr3:49044727 WDR6 0.59 6.47 0.34 3.56e-10 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs916888 0.773 rs199534 chr17:44824213 T/G cg17911788 chr17:44343683 NA -0.67 -7.35 -0.38 1.55e-12 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs3091242 0.934 rs666686 chr1:25719511 A/G cg20684491 chr1:25596433 NA 0.42 7.37 0.38 1.41e-12 Erythrocyte sedimentation rate; CRC cis rs6674176 0.660 rs12726706 chr1:44399942 G/A cg12908607 chr1:44402522 ARTN -0.58 -10.5 -0.5 1.94e-22 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Cognitive ability; CRC cis rs172166 0.694 rs1150666 chr6:28123928 T/C cg10876282 chr6:28092338 ZSCAN16 0.5 6.73 0.35 7.44e-11 Cardiac Troponin-T levels; CRC cis rs4665809 1.000 rs6546727 chr2:26275282 C/T cg25036284 chr2:26402008 FAM59B -0.46 -6.02 -0.32 4.54e-9 Gut microbiome composition (summer); CRC cis rs28386778 0.742 rs3020617 chr17:61947303 A/G cg23090583 chr17:61904693 PSMC5;FTSJ3 1.02 18.85 0.72 3e-54 Prudent dietary pattern; CRC trans rs2228479 1.000 rs12596492 chr16:89957169 T/G cg21302420 chr1:112162376 RAP1A 0.83 7.41 0.38 1.07e-12 Skin colour saturation; CRC cis rs10512697 0.655 rs35747152 chr5:3459151 T/C cg19473799 chr5:3511975 NA -0.83 -6.34 -0.33 7.66e-10 Immune response to smallpox vaccine (IL-6); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg25117062 chr2:10442836 HPCAL1 0.4 6.75 0.35 6.89e-11 Liver disease severity in Alagille syndrome; CRC cis rs10540 1.000 rs35898083 chr11:484469 C/T cg21784768 chr11:537496 LRRC56 -0.67 -6.21 -0.32 1.63e-9 Body mass index; CRC cis rs17270561 0.562 rs12199626 chr6:26013604 G/A cg17691542 chr6:26056736 HIST1H1C 0.97 11.59 0.54 2.78e-26 Iron status biomarkers; CRC cis rs11628318 0.538 rs1190339 chr14:103103876 C/T cg12046867 chr14:103022105 NA -0.43 -6.22 -0.32 1.53e-9 Platelet count; CRC cis rs17001868 0.568 rs9611318 chr22:40739414 C/G cg07138101 chr22:40742427 ADSL 0.59 7.76 0.39 1.06e-13 Mammographic density (dense area); CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg10922622 chr9:108210153 FSD1L 0.47 6.07 0.32 3.51e-9 Thyroid stimulating hormone; CRC cis rs9372498 0.505 rs62424173 chr6:118780507 C/G cg01339444 chr6:118972232 C6orf204 0.54 6.02 0.32 4.65e-9 Diastolic blood pressure; CRC cis rs1816752 0.905 rs9511249 chr13:24999595 G/A cg02811702 chr13:24901961 NA 0.42 5.78 0.3 1.73e-8 Obesity-related traits; CRC cis rs8062405 0.824 rs4788085 chr16:28535003 A/G cg16576597 chr16:28551801 NUPR1 0.44 6.75 0.35 6.53e-11 Cognitive ability (multi-trait analysis);Cognitive ability; CRC cis rs1008375 0.932 rs6449321 chr4:17644472 A/G cg02297831 chr4:17616191 MED28 0.47 6.23 0.32 1.43e-9 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs826838 0.868 rs12322306 chr12:39130021 A/G cg13010199 chr12:38710504 ALG10B -0.41 -5.84 -0.31 1.27e-8 Heart rate; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg07254608 chr8:41997973 NA 0.48 6.27 0.33 1.1e-9 Thyroid stimulating hormone; CRC cis rs12410462 0.892 rs35341041 chr1:227653885 G/A cg23173402 chr1:227635558 NA 0.71 8.01 0.4 2.03e-14 Major depressive disorder; CRC cis rs10911232 0.507 rs10911212 chr1:183024469 C/T ch.1.3577855R chr1:183094577 LAMC1 0.83 14.62 0.63 1.24e-37 Hypertriglyceridemia; CRC cis rs7666738 0.830 rs1025203 chr4:99023073 G/A cg17366294 chr4:99064904 C4orf37 0.44 7.36 0.38 1.44e-12 Colonoscopy-negative controls vs population controls; CRC cis rs7940866 0.801 rs10894300 chr11:130845943 A/G cg12179176 chr11:130786555 SNX19 0.59 8.58 0.43 3.7e-16 Schizophrenia; CRC cis rs11649653 0.502 rs11864054 chr16:30846134 G/A cg02466173 chr16:30829666 NA -0.58 -8.1 -0.41 1.1e-14 Triglycerides; CRC cis rs35110281 0.720 rs162375 chr21:44927015 C/T cg04455712 chr21:45112962 RRP1B -0.42 -7.98 -0.4 2.39e-14 Mean corpuscular volume; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg19250579 chr3:75487529 NA -0.37 -6.06 -0.32 3.78e-9 Liver disease severity in Alagille syndrome; CRC trans rs6550704 0.687 rs9865314 chr3:22634337 A/G cg27472102 chr12:77459941 E2F7 -0.38 -6.08 -0.32 3.36e-9 Daytime sleep phenotypes; CRC cis rs6772849 0.930 rs9813197 chr3:128369104 G/A cg08795948 chr3:128337044 NA 0.35 6.18 0.32 1.93e-9 Monocyte percentage of white cells;Monocyte count; CRC cis rs9329221 0.592 rs7832708 chr8:10190040 C/T cg27411982 chr8:10470053 RP1L1 0.35 5.62 0.3 4.05e-8 Neuroticism; CRC cis rs8060686 0.641 rs12599880 chr16:68152035 A/G cg08314208 chr16:67682810 RLTPR -0.64 -6.73 -0.35 7.38e-11 HDL cholesterol;Metabolic syndrome; CRC cis rs2303759 0.918 rs9749416 chr19:49885005 G/A cg22133161 chr19:49891603 CCDC155 0.49 6.9 0.36 2.74e-11 Multiple sclerosis; CRC cis rs933688 1.000 rs12656350 chr5:90751343 C/T cg02339078 chr5:90679543 LOC100129716;ARRDC3 0.9 13.92 0.61 5.73e-35 Smoking behavior; CRC cis rs10760158 0.736 rs10760168 chr9:124048727 C/T cg14417974 chr9:124058376 GSN -0.33 -5.61 -0.3 4.38e-8 Pulse pressure; CRC cis rs12220238 0.908 rs4746179 chr10:75940169 C/G cg19889307 chr10:75911429 ADK;AP3M1 0.57 5.78 0.3 1.73e-8 Soluble interleukin-2 receptor subunit alpha; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg24022402 chr3:9834453 ARPC4;TADA3 0.44 6.04 0.32 4.23e-9 Response to antipsychotic treatment; CRC cis rs4843747 0.671 rs9921236 chr16:88117015 G/T cg03395651 chr16:88107091 BANP 0.56 7.43 0.38 9.52e-13 Menopause (age at onset); CRC cis rs12692738 0.526 rs355827 chr2:165612448 C/A cg03182029 chr2:165697222 COBLL1 0.49 5.68 0.3 2.91e-8 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);Waist-to-hip ratio adjusted for BMI in non-smokers;Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction);Waist-to-hip ratio adjusted for body mass index; CRC cis rs2439831 0.702 rs28699233 chr15:44122866 A/G cg02155558 chr15:43621948 ADAL;LCMT2 0.75 7.11 0.37 7.09e-12 Lung cancer in ever smokers; CRC cis rs7605827 0.964 rs10929367 chr2:15564718 T/C cg19274914 chr2:15703543 NA 0.37 5.7 0.3 2.69e-8 Educational attainment (years of education); CRC cis rs7811142 1.000 rs76913697 chr7:100002772 A/G cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.76 10.46 0.5 2.59e-22 Platelet count; CRC trans rs637571 0.615 rs10160792 chr11:65667149 C/G cg17712092 chr4:129076599 LARP1B 0.93 17.69 0.7 1.09e-49 Eosinophil percentage of white cells; CRC cis rs1799949 1.000 rs2175957 chr17:41286822 T/G cg05368731 chr17:41323189 NBR1 0.69 10.5 0.5 1.91e-22 Menopause (age at onset); CRC cis rs8078723 0.714 rs8070444 chr17:38151960 A/G cg17467752 chr17:38218738 THRA -0.57 -9.01 -0.44 1.75e-17 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); CRC cis rs7613875 0.620 rs11721204 chr3:49982765 C/T cg05623727 chr3:50126028 RBM5 0.6 10.26 0.49 1.3e-21 Body mass index; CRC cis rs8067545 0.750 rs34290687 chr17:19991211 G/A cg13482628 chr17:19912719 NA 0.47 7.62 0.39 2.75e-13 Schizophrenia; CRC cis rs2932538 0.922 rs17438324 chr1:113100573 C/T cg22162597 chr1:113214053 CAPZA1 0.7 10.13 0.49 3.68e-21 Systolic blood pressure;Diastolic blood pressure;Hypertension;Blood pressure; CRC cis rs7546094 1.000 rs7524494 chr1:113197800 A/G cg22162597 chr1:113214053 CAPZA1 -0.42 -5.75 -0.3 2.04e-8 Platelet distribution width; CRC cis rs10504229 0.775 rs17805026 chr8:58160637 A/C cg05313129 chr8:58192883 C8orf71 -0.48 -6.25 -0.33 1.29e-9 Developmental language disorder (linguistic errors); CRC cis rs75920871 0.528 rs11600552 chr11:116900947 T/C cg01368799 chr11:117014884 PAFAH1B2 -0.41 -5.84 -0.31 1.26e-8 Subjective well-being; CRC cis rs7412746 0.611 rs10888395 chr1:150762171 C/T cg15448220 chr1:150897856 SETDB1 0.51 7.19 0.37 4.25e-12 Melanoma; CRC trans rs11039798 0.588 rs1814768 chr11:48987455 T/C cg03929089 chr4:120376271 NA 0.63 6.55 0.34 2.18e-10 Axial length; CRC cis rs763014 0.932 rs2269560 chr16:682442 A/C cg03804128 chr16:635623 NA 0.31 7.14 0.37 6.06e-12 Height; CRC cis rs8044868 0.541 rs7202268 chr16:72086746 A/G cg06172871 chr16:72088244 HP 0.43 6.35 0.33 7.3e-10 Body mass index (change over time) in cancer or chronic obstructive pulmonary disease;Body mass index (change over time) in cancer; CRC cis rs881375 0.967 rs7034492 chr9:123687211 G/A cg00246817 chr9:123691163 NA -0.44 -5.65 -0.3 3.44e-8 Rheumatoid arthritis; CRC cis rs7095944 0.644 rs965484 chr10:126453481 T/C cg08799069 chr10:126477246 METTL10 -0.44 -6.84 -0.35 3.81e-11 Asthma; CRC cis rs9921222 0.521 rs11649255 chr16:357140 A/G cg26944245 chr16:421049 TMEM8A;MRPL28 0.42 5.79 0.3 1.66e-8 Bone mineral density (spine);Bone mineral density; CRC cis rs4700695 0.764 rs251320 chr5:65237435 G/A cg21114390 chr5:65439923 SFRS12 0.59 6.54 0.34 2.4e-10 Facial morphology (factor 19); CRC cis rs7172677 0.768 rs72730585 chr15:75353906 A/G cg14664628 chr15:75095509 CSK 0.55 6.6 0.34 1.66e-10 Systemic lupus erythematosus and Systemic sclerosis; CRC cis rs8005677 0.962 rs34917191 chr14:23387628 T/C cg01529538 chr14:23388837 RBM23 0.4 6.18 0.32 1.86e-9 Cognitive ability (multi-trait analysis); CRC cis rs4481887 1.000 rs9660769 chr1:248484558 C/G cg13385794 chr1:248469461 NA -0.4 -7.02 -0.36 1.28e-11 Common traits (Other); CRC cis rs1448094 0.845 rs7966131 chr12:86350633 T/G cg02569458 chr12:86230093 RASSF9 0.48 7.98 0.4 2.39e-14 Major depressive disorder; CRC cis rs4474465 0.790 rs10793331 chr11:78270000 C/T cg02023728 chr11:77925099 USP35 -0.35 -5.96 -0.31 6.32e-9 Alzheimer's disease (survival time); CRC cis rs9787249 0.957 rs7518431 chr1:40214944 C/T cg02773041 chr1:40204384 PPIE -0.63 -9.33 -0.46 1.67e-18 Blood protein levels; CRC cis rs977987 0.843 rs6564260 chr16:75447426 A/G cg03315344 chr16:75512273 CHST6 0.54 9.08 0.45 1.04e-17 Dupuytren's disease; CRC cis rs939574 0.790 rs114196239 chr2:220094307 G/A cg00496455 chr2:220118770 TUBA4A;TUBA4B 0.91 8.44 0.42 1.06e-15 Platelet distribution width; CRC cis rs6502050 0.835 rs9901076 chr17:80170020 G/A cg13198984 chr17:80129470 CCDC57 0.47 8.29 0.42 2.97e-15 Life satisfaction; CRC trans rs7730934 1.000 rs11739016 chr5:55263373 C/T cg10323188 chr3:28613979 NA 0.52 6.11 0.32 2.84e-9 Blood protein levels; CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg21517261 chr7:38217791 STARD3NL -0.51 -6.27 -0.33 1.15e-9 Diisocyanate-induced asthma; CRC cis rs9443645 0.901 rs9343844 chr6:79586463 T/A cg09184832 chr6:79620586 NA -0.52 -9.73 -0.47 7.62e-20 Intelligence (multi-trait analysis); CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg05550371 chr3:49841167 C3orf54 0.5 6.34 0.33 7.62e-10 Thyroid stimulating hormone; CRC cis rs10504229 0.683 rs56192850 chr8:58135356 A/G cg24829409 chr8:58192753 C8orf71 -0.55 -8.03 -0.4 1.71e-14 Developmental language disorder (linguistic errors); CRC cis rs7762018 1.000 rs6904601 chr6:170131905 T/G cg19338460 chr6:170058176 WDR27 -0.68 -7.49 -0.38 6.42e-13 Thiazide-induced adverse metabolic effects in hypertensive patients; CRC trans rs11039798 0.588 rs10838979 chr11:48626810 T/G cg15704280 chr7:45808275 SEPT13 0.65 6.93 0.36 2.21e-11 Axial length; CRC cis rs2535633 0.602 rs6801235 chr3:53009595 T/C cg05573699 chr3:52720067 GNL3;PBRM1 -0.41 -5.95 -0.31 6.74e-9 Body mass index; CRC cis rs9372498 0.572 rs62422190 chr6:118909235 A/G cg01339444 chr6:118972232 C6orf204 0.53 5.87 0.31 1.04e-8 Diastolic blood pressure; CRC cis rs2580764 0.598 rs6755468 chr2:55240026 A/C cg09592903 chr2:55203963 RTN4 -0.72 -11.45 -0.53 8.76e-26 Mean platelet volume; CRC cis rs7914558 1.000 rs8139 chr10:104848123 G/A cg04362960 chr10:104952993 NT5C2 0.6 8.99 0.44 1.96e-17 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs1023500 0.505 rs134891 chr22:42675882 T/C cg04733989 chr22:42467013 NAGA 0.41 5.9 0.31 9.25e-9 Schizophrenia; CRC cis rs10504229 0.775 rs55734109 chr8:58162322 G/A cg24829409 chr8:58192753 C8orf71 -0.62 -8.03 -0.4 1.81e-14 Developmental language disorder (linguistic errors); CRC cis rs875971 0.660 rs2013222 chr7:66035936 C/G cg11764359 chr7:65958608 NA -0.54 -8.54 -0.43 5e-16 Aortic root size; CRC cis rs6686643 0.762 rs9333433 chr1:165611455 G/C cg19407955 chr1:165599744 MGST3 -0.52 -6.62 -0.34 1.49e-10 Total ventricular volume; CRC cis rs7618915 0.571 rs11130307 chr3:52607682 G/A cg15147215 chr3:52552868 STAB1 -0.63 -10.56 -0.5 1.18e-22 Bipolar disorder; CRC cis rs853679 1.000 rs853694 chr6:28279100 A/T cg15786705 chr6:28176104 NA 0.57 5.99 0.31 5.57e-9 Depression; CRC cis rs1008375 0.932 rs6835077 chr4:17653285 A/T cg16339924 chr4:17578868 LAP3 0.52 6.59 0.34 1.72e-10 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs7412746 0.566 rs2864871 chr1:150766964 T/C cg15448220 chr1:150897856 SETDB1 0.53 7.45 0.38 8.42e-13 Melanoma; CRC cis rs6662572 0.737 rs6674105 chr1:46301379 G/T cg03123370 chr1:45965343 CCDC163P;MMACHC -0.48 -6.09 -0.32 3.11e-9 Blood protein levels; CRC cis rs9372498 0.536 rs17080302 chr6:118854037 A/G cg01339444 chr6:118972232 C6orf204 0.53 6.0 0.31 5.22e-9 Diastolic blood pressure; CRC cis rs7618501 0.633 rs4688757 chr3:50035323 T/C cg24308560 chr3:49941425 MST1R -0.51 -8.36 -0.42 1.83e-15 Intelligence (multi-trait analysis); CRC cis rs7605827 0.930 rs11675805 chr2:15578274 C/T cg19274914 chr2:15703543 NA 0.39 6.02 0.31 4.78e-9 Educational attainment (years of education); CRC cis rs2153535 0.563 rs1737585 chr6:8536594 A/G cg21535247 chr6:8435926 SLC35B3 -0.51 -7.8 -0.39 8.46e-14 Motion sickness; CRC cis rs684232 0.602 rs401592 chr17:551316 T/C cg15660573 chr17:549704 VPS53 -0.86 -15.83 -0.66 2.31e-42 Prostate cancer; CRC trans rs172642 1.000 rs218696 chr17:6593922 A/G cg26561570 chr1:161602002 FCGR3B -0.28 -6.43 -0.33 4.43e-10 Metabolite levels (small molecules and protein measures); CRC cis rs7539624 0.529 rs7412088 chr1:223899123 T/A cg10100437 chr1:223903862 CAPN2 0.46 6.46 0.34 3.84e-10 Schizophrenia; CRC cis rs2836950 0.501 rs2836980 chr21:40687618 G/T cg11644478 chr21:40555479 PSMG1 -0.44 -6.53 -0.34 2.56e-10 Menarche (age at onset); CRC cis rs7917772 0.582 rs10786696 chr10:104378134 A/G cg11453585 chr10:104263688 ACTR1A;SUFU 0.81 14.95 0.64 6.44e-39 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC trans rs6703335 0.870 rs10803142 chr1:243598234 A/G cg27579711 chr6:26172931 NA 0.45 6.4 0.33 5.2e-10 Schizophrenia;Schizophrenia, schizoaffective disorder or bipolar disorder; CRC cis rs10504229 0.645 rs35142596 chr8:58128151 C/T cg05313129 chr8:58192883 C8orf71 -0.43 -6.11 -0.32 2.74e-9 Developmental language disorder (linguistic errors); CRC cis rs898097 0.841 rs55810435 chr17:80836722 G/C cg03160526 chr17:80928410 B3GNTL1 -0.41 -5.93 -0.31 7.68e-9 Breast cancer; CRC cis rs7591163 1.000 rs7574255 chr2:228699884 C/G cg23807890 chr2:228736357 WDR69 0.49 6.65 0.34 1.2e-10 Blood pressure; CRC cis rs9560113 1.000 rs4773384 chr13:112177987 A/G cg10483660 chr13:112241077 NA 0.36 5.82 0.31 1.39e-8 Menarche (age at onset); CRC cis rs910316 0.935 rs11159119 chr14:75636967 C/T cg08847533 chr14:75593920 NEK9 -0.97 -18.5 -0.71 7.08e-53 Height; CRC cis rs1401999 0.690 rs6768149 chr3:183636195 T/C cg01324343 chr3:183735012 ABCC5 0.6 9.51 0.46 4.26e-19 Anterior chamber depth; CRC cis rs2836974 0.897 rs36113648 chr21:40555497 G/A cg11890956 chr21:40555474 PSMG1 1.13 21.01 0.76 9.76e-63 Cognitive function; CRC trans rs9747201 1.000 rs58472289 chr17:80111895 G/T cg07393940 chr7:158741817 NA -0.52 -7.43 -0.38 9.26e-13 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs10504229 0.728 rs17804774 chr8:58155950 G/T cg11062466 chr8:58055876 NA 0.45 5.88 0.31 1.01e-8 Developmental language disorder (linguistic errors); CRC cis rs7208859 0.524 rs59913838 chr17:29101563 A/T cg13385521 chr17:29058706 SUZ12P 0.73 8.33 0.42 2.14e-15 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC trans rs1200821 0.535 rs1208789 chr10:37722472 A/G cg25427524 chr10:38739819 LOC399744 -0.56 -8.68 -0.43 1.91e-16 Hemostatic factors and hematological phenotypes; CRC cis rs7312933 0.558 rs11181502 chr12:42823833 A/G cg19980929 chr12:42632907 YAF2 0.42 6.37 0.33 6.19e-10 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CRC cis rs9875589 0.957 rs6778297 chr3:13932143 C/T cg14375111 chr3:14165186 TMEM43;CHCHD4 -0.39 -5.77 -0.3 1.88e-8 Ovarian reserve; CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg08808811 chr3:184079573 CLCN2 0.4 6.37 0.33 6.22e-10 Obesity-related traits; CRC cis rs9322193 0.962 rs62439843 chr6:149997657 T/C cg13206674 chr6:150067644 NUP43 0.57 8.14 0.41 8.11e-15 Lung cancer; CRC cis rs1550582 0.917 rs7831961 chr8:135507060 C/G cg17885191 chr8:135476712 NA -0.76 -10.27 -0.49 1.19e-21 Educational attainment; CRC cis rs9928842 0.823 rs2870472 chr16:75278841 C/G cg08657710 chr16:75258780 CTRB1 -0.57 -6.81 -0.35 4.61e-11 Alcoholic chronic pancreatitis; CRC cis rs9487051 1.000 rs9487052 chr6:109617086 C/T cg01475377 chr6:109611718 NA -0.45 -8.03 -0.4 1.75e-14 Reticulocyte fraction of red cells; CRC cis rs875971 0.825 rs59466412 chr7:65565358 A/G cg18252515 chr7:66147081 NA 0.4 5.9 0.31 9.26e-9 Aortic root size; CRC cis rs727505 0.954 rs17327014 chr7:124709349 C/T cg23710748 chr7:124431027 NA -0.79 -13.83 -0.61 1.33e-34 Lewy body disease; CRC cis rs863345 0.604 rs10908654 chr1:158455790 A/T cg12129480 chr1:158549410 OR10X1 -0.29 -6.03 -0.32 4.44e-9 Pneumococcal bacteremia; CRC cis rs4969178 0.965 rs3817294 chr17:76396963 A/G cg20026190 chr17:76395443 PGS1 0.4 6.2 0.32 1.73e-9 HDL cholesterol levels; CRC cis rs728616 0.867 rs3088308 chr10:81697868 A/T cg05935833 chr10:81318306 SFTPA2 -0.72 -8.19 -0.41 5.66e-15 Chronic obstructive pulmonary disease-related biomarkers; CRC trans rs2303319 0.582 rs56315911 chr2:162560186 G/T cg12500891 chr11:57225987 NA -0.66 -6.09 -0.32 3.19e-9 Cognitive function; CRC cis rs911119 0.908 rs8121147 chr20:23601708 T/C cg16589663 chr20:23618590 CST3 0.47 6.5 0.34 2.92e-10 Chronic kidney disease; CRC cis rs6121246 0.559 rs6121038 chr20:30254773 T/G cg13852791 chr20:30311386 BCL2L1 0.72 14.1 0.61 1.18e-35 Mean corpuscular hemoglobin; CRC trans rs11098499 0.863 rs2306457 chr4:120472839 T/A cg25214090 chr10:38739885 LOC399744 0.67 10.49 0.5 2.12e-22 Corneal astigmatism; CRC cis rs8103278 1.000 rs7256192 chr19:46338492 G/A cg14061069 chr19:46274453 DMPK -0.54 -7.96 -0.4 2.81e-14 Coronary artery disease; CRC cis rs9660992 0.624 rs72745217 chr1:205261482 C/G cg21643547 chr1:205240462 TMCC2 -0.44 -7.06 -0.36 1.01e-11 Mean corpuscular volume;Mean platelet volume; CRC cis rs3540 0.597 rs3743409 chr15:91045539 T/A cg22089800 chr15:90895588 ZNF774 -0.57 -9.51 -0.46 4.26e-19 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; CRC cis rs9916302 0.847 rs7218670 chr17:37500424 G/A cg07936489 chr17:37558343 FBXL20 0.79 11.88 0.55 2.48e-27 Glomerular filtration rate (creatinine); CRC trans rs10506710 0.537 rs7964194 chr12:73563639 A/G cg13063900 chr12:20810676 PDE3A -0.39 -5.99 -0.31 5.42e-9 Systolic blood pressure; CRC cis rs1707322 1.000 rs1768801 chr1:46549137 C/G cg06784218 chr1:46089804 CCDC17 -0.55 -9.67 -0.47 1.26e-19 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs10504229 0.593 rs16921626 chr8:58040359 C/T cg21724239 chr8:58056113 NA 0.52 7.04 0.36 1.1e-11 Developmental language disorder (linguistic errors); CRC cis rs1008375 1.000 rs4698200 chr4:17657051 G/A cg04450456 chr4:17643702 FAM184B 0.39 6.4 0.33 5.42e-10 Parasitemia in Tripanosoma cruzi seropositivity; CRC trans rs9929218 0.954 rs112225541 chr16:68755165 C/T cg04657470 chr2:198365150 HSPE1;HSPD1 -0.97 -14.46 -0.62 4.86e-37 Colorectal cancer; CRC cis rs9487051 0.872 rs9386793 chr6:109610002 C/A cg12927641 chr6:109611667 NA -0.38 -6.93 -0.36 2.18e-11 Reticulocyte fraction of red cells; CRC cis rs1448094 0.534 rs11613070 chr12:86167544 T/A cg18827107 chr12:86230957 RASSF9 -0.41 -6.23 -0.32 1.42e-9 Major depressive disorder; CRC cis rs4665809 0.590 rs7606351 chr2:26292545 A/C cg27170947 chr2:26402098 FAM59B -0.45 -5.61 -0.3 4.38e-8 Gut microbiome composition (summer); CRC cis rs7607369 0.536 rs13033409 chr2:219666509 T/G cg02176678 chr2:219576539 TTLL4 -0.39 -6.36 -0.33 6.89e-10 Red blood cell count;Amyotrophic lateral sclerosis; CRC cis rs6429082 0.509 rs12027995 chr1:235517607 C/G cg26050004 chr1:235667680 B3GALNT2 0.42 5.9 0.31 8.86e-9 Adiposity; CRC cis rs7247513 0.930 rs35275129 chr19:12716493 G/A cg04657146 chr19:12876947 HOOK2 0.39 5.61 0.3 4.32e-8 Bipolar disorder; CRC cis rs10979 0.557 rs9390116 chr6:143907577 A/G cg25407410 chr6:143891975 LOC285740 -0.62 -8.31 -0.42 2.53e-15 Hypospadias; CRC cis rs6693567 0.545 rs9436009 chr1:150459426 T/A cg15654264 chr1:150340011 RPRD2 0.41 6.14 0.32 2.36e-9 Migraine; CRC cis rs4654899 0.865 rs6665549 chr1:21475884 G/C cg02927042 chr1:21476669 EIF4G3 -0.51 -7.98 -0.4 2.4e-14 Superior frontal gyrus grey matter volume; CRC cis rs2717559 0.542 rs2717586 chr8:143897882 C/T cg22687807 chr8:143858763 LYNX1 0.72 12.97 0.58 2.3e-31 Urinary tract infection frequency; CRC cis rs62458065 0.850 rs6462362 chr7:32464733 C/T cg20159608 chr7:32802032 NA -0.53 -6.6 -0.34 1.62e-10 Metabolite levels (HVA/MHPG ratio); CRC cis rs2795502 0.872 rs2744062 chr10:43254789 T/A cg20628663 chr10:43360327 NA -0.66 -8.28 -0.42 3.19e-15 Blood protein levels; CRC cis rs9329289 0.632 rs2452187 chr10:2551147 C/G cg18171855 chr10:2543474 NA 0.41 6.67 0.34 1.1e-10 Age-related hearing impairment; CRC cis rs7119 0.651 rs12902898 chr15:77849191 A/G cg10437265 chr15:77819839 NA 0.56 9.34 0.46 1.5e-18 Type 2 diabetes; CRC cis rs651907 0.535 rs4342086 chr3:101503765 G/A cg11279151 chr3:101281821 RG9MTD1 -0.52 -7.01 -0.36 1.36e-11 Colorectal cancer; CRC cis rs6502050 0.835 rs34960918 chr17:80113925 A/G cg19223190 chr17:80058835 NA 0.4 6.36 0.33 6.88e-10 Life satisfaction; CRC cis rs10256972 0.552 rs2949192 chr7:1203841 C/T cg18402987 chr7:1209562 NA 0.54 8.21 0.41 5.07e-15 Longevity;Endometriosis; CRC cis rs35740288 0.571 rs11631009 chr15:86318653 G/A cg20737812 chr15:86336631 KLHL25 -0.49 -7.23 -0.37 3.44e-12 Eosinophil percentage of white cells;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes; CRC cis rs734999 0.545 rs10752748 chr1:2544640 G/A cg20673091 chr1:2541236 MMEL1 0.36 5.91 0.31 8.75e-9 Ulcerative colitis; CRC cis rs7937682 0.575 rs7930208 chr11:111741463 T/C cg09085632 chr11:111637200 PPP2R1B 0.95 15.63 0.65 1.46e-41 Primary sclerosing cholangitis; CRC cis rs7615952 0.641 rs66520539 chr3:125780374 G/A cg02772935 chr3:125709198 NA -0.49 -5.74 -0.3 2.11e-8 Blood pressure (smoking interaction); CRC cis rs10504229 1.000 rs77823122 chr8:58170161 A/G cg01721255 chr8:58191610 C8orf71 0.49 6.17 0.32 2e-9 Developmental language disorder (linguistic errors); CRC cis rs12477438 0.765 rs1115757 chr2:99660146 G/A cg14399236 chr2:99771627 LIPT1;TSGA10 -0.6 -8.19 -0.41 6.03e-15 Chronic sinus infection; CRC cis rs796364 0.806 rs11684895 chr2:201009026 C/T cg25936922 chr2:200820526 C2orf60;C2orf47 -0.65 -6.15 -0.32 2.23e-9 Schizophrenia; CRC cis rs2795502 0.564 rs72777187 chr10:43432224 C/T cg08461752 chr10:43522343 NA -0.63 -5.87 -0.31 1.07e-8 Blood protein levels; CRC cis rs3772130 0.962 rs4413346 chr3:121486310 A/G cg20356878 chr3:121714668 ILDR1 0.52 8.1 0.41 1.09e-14 Cognitive performance; CRC cis rs9322193 0.923 rs11155671 chr6:149972132 G/A cg00933542 chr6:150070202 PCMT1 0.29 5.98 0.31 5.88e-9 Lung cancer; CRC cis rs9368481 0.743 rs9368480 chr6:26955750 A/C cg07220782 chr6:26987966 LOC100270746;C6orf41 0.41 5.65 0.3 3.48e-8 Autism spectrum disorder or schizophrenia; CRC trans rs12599106 0.648 rs12447240 chr16:34928236 C/T cg11235426 chr6:292522 DUSP22 0.66 9.49 0.46 4.72e-19 Menopause (age at onset); CRC cis rs7208859 0.673 rs11651802 chr17:29159660 T/C cg14008862 chr17:28927542 LRRC37B2 0.55 5.78 0.3 1.7e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs10512697 0.655 rs13170915 chr5:3511974 G/A cg19473799 chr5:3511975 NA -0.83 -6.34 -0.33 7.66e-10 Immune response to smallpox vaccine (IL-6); CRC cis rs7107174 0.581 rs11237485 chr11:78126011 G/A cg02023728 chr11:77925099 USP35 0.41 6.27 0.33 1.15e-9 Testicular germ cell tumor; CRC cis rs4588572 0.601 rs1529500 chr5:77721643 C/T cg11547950 chr5:77652471 NA -0.52 -7.24 -0.37 3.15e-12 Triglycerides; CRC cis rs769267 0.930 rs2288852 chr19:19605348 T/C cg02546618 chr19:19431379 KIAA0892;SF4 0.45 6.1 0.32 3.01e-9 Tonsillectomy; CRC cis rs13191362 1.000 rs73016459 chr6:163066323 C/A cg14584255 chr6:163149320 PACRG;PARK2 0.44 6.36 0.33 6.71e-10 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg07544984 chr3:42845911 HIGD1A 0.38 6.04 0.32 4.2e-9 Liver disease severity in Alagille syndrome; CRC cis rs877282 0.891 rs34383514 chr10:800181 T/C cg06581033 chr10:766294 NA -0.5 -5.62 -0.3 3.99e-8 Uric acid levels; CRC cis rs13191362 0.507 rs2849520 chr6:163132038 T/C cg06582575 chr6:163149167 PACRG;PARK2 -0.62 -9.5 -0.46 4.49e-19 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs7726839 0.561 rs56410216 chr5:583216 C/A cg16447950 chr5:562315 NA -0.85 -12.52 -0.57 1.1e-29 Obesity-related traits; CRC cis rs4253772 0.550 rs6007779 chr22:46678615 A/C cg24881330 chr22:46731750 TRMU 0.7 8.79 0.44 8.56e-17 LDL cholesterol;Cholesterol, total; CRC cis rs9325144 0.647 rs61931899 chr12:38892422 A/G cg26384229 chr12:38710491 ALG10B -0.51 -7.26 -0.37 2.76e-12 Morning vs. evening chronotype; CRC trans rs2727020 0.553 rs3907576 chr11:49536639 A/C cg03929089 chr4:120376271 NA -0.92 -17.0 -0.68 5.84e-47 Coronary artery disease; CRC cis rs7258465 1.000 rs4595905 chr19:18547305 T/A cg06462663 chr19:18546047 ISYNA1 0.5 7.39 0.38 1.26e-12 Breast cancer; CRC cis rs863345 0.604 rs10908657 chr1:158465243 T/C cg12129480 chr1:158549410 OR10X1 -0.3 -6.35 -0.33 7.19e-10 Pneumococcal bacteremia; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg04413696 chr16:17564591 XYLT1 0.45 6.3 0.33 9.7e-10 Anxiety disorder; CRC cis rs7618915 0.571 rs67539070 chr3:52711974 T/C cg18404041 chr3:52824283 ITIH1 -0.43 -8.74 -0.43 1.21e-16 Bipolar disorder; CRC trans rs875971 0.660 rs2191268 chr7:66110224 C/T cg10989255 chr10:76970356 VDAC2 -0.37 -6.21 -0.32 1.63e-9 Aortic root size; CRC cis rs2204008 0.701 rs3898237 chr12:38219714 A/G cg13010199 chr12:38710504 ALG10B 0.44 5.62 0.3 4.1e-8 Bladder cancer; CRC cis rs875971 0.825 rs6951503 chr7:65718936 T/G cg12463550 chr7:65579703 CRCP -0.49 -6.52 -0.34 2.68e-10 Aortic root size; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg26837270 chr19:42746884 GSK3A 0.4 5.98 0.31 5.88e-9 Intelligence (multi-trait analysis); CRC cis rs6912958 0.678 rs9450733 chr6:88250081 C/T cg12350822 chr6:88032061 C6orf162;GJB7 -0.33 -6.36 -0.33 6.84e-10 Monocyte percentage of white cells; CRC cis rs7771547 0.573 rs9470274 chr6:36397229 G/A cg07856975 chr6:36356162 ETV7 0.4 5.91 0.31 8.7e-9 Platelet distribution width; CRC cis rs847577 0.630 rs13221758 chr7:97719806 A/C cg21770322 chr7:97807741 LMTK2 0.85 19.35 0.73 3.14e-56 Breast cancer; CRC trans rs473651 0.935 rs578510 chr2:239343140 C/T cg13521940 chr21:36262239 RUNX1 -0.41 -6.06 -0.32 3.67e-9 Multiple system atrophy; CRC trans rs7618501 0.521 rs11709573 chr3:49956628 C/T cg21665057 chr3:196295764 WDR53;FBXO45 0.45 6.43 0.33 4.61e-10 Intelligence (multi-trait analysis); CRC cis rs1862618 0.802 rs252900 chr5:56185281 T/A cg03609598 chr5:56110824 MAP3K1 -0.85 -10.06 -0.49 6.18e-21 Initial pursuit acceleration; CRC cis rs172166 0.694 rs203893 chr6:28062066 C/A cg02631126 chr6:28058918 ZSCAN12L1 0.24 5.67 0.3 3.08e-8 Cardiac Troponin-T levels; CRC cis rs10504229 0.683 rs903702 chr8:58128557 T/C cg02290350 chr8:58132656 NA -0.58 -8.16 -0.41 7.29e-15 Developmental language disorder (linguistic errors); CRC cis rs11785400 0.793 rs4587307 chr8:143738529 G/A cg10596483 chr8:143751796 JRK 0.44 5.9 0.31 8.94e-9 Schizophrenia; CRC cis rs10751667 0.666 rs4072741 chr11:976565 T/C ch.11.42038R chr11:967971 AP2A2 0.57 9.86 0.48 2.86e-20 Alzheimer's disease (late onset); CRC cis rs2692947 0.760 rs2438924 chr2:96645069 A/G cg23100626 chr2:96804247 ASTL 0.25 6.92 0.36 2.31e-11 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; CRC cis rs10504229 0.639 rs56825757 chr8:58106469 A/G cg24829409 chr8:58192753 C8orf71 -0.56 -8.01 -0.4 2.05e-14 Developmental language disorder (linguistic errors); CRC cis rs9388451 1.000 rs9388451 chr6:126090377 A/G cg05901451 chr6:126070800 HEY2 -0.64 -11.24 -0.53 5.05e-25 Brugada syndrome; CRC cis rs9354352 0.791 rs4710306 chr6:66700271 A/G cg07460842 chr6:66804631 NA -0.59 -8.64 -0.43 2.51e-16 Initial pursuit acceleration in psychotic disorders; CRC cis rs2204008 0.744 rs8186814 chr12:38335169 C/T cg26384229 chr12:38710491 ALG10B 0.68 9.52 0.46 3.79e-19 Bladder cancer; CRC cis rs7567389 0.534 rs72845982 chr2:128098570 G/A cg09760422 chr2:128146352 NA 0.34 5.61 0.3 4.2e-8 Self-rated health; CRC cis rs4969178 0.641 rs4969141 chr17:76391653 C/T cg05887092 chr17:76393375 PGS1 0.65 13.12 0.59 6.34e-32 HDL cholesterol levels; CRC cis rs10504229 1.000 rs67895971 chr8:58177994 A/G cg24829409 chr8:58192753 C8orf71 -0.68 -11.34 -0.53 2.27e-25 Developmental language disorder (linguistic errors); CRC cis rs7927771 0.864 rs11604680 chr11:47457539 A/G cg20307385 chr11:47447363 PSMC3 -0.62 -8.74 -0.43 1.2e-16 Subjective well-being; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg19864851 chr10:75503847 SEC24C 0.51 6.7 0.35 9.01e-11 Thyroid stimulating hormone; CRC cis rs7940866 0.801 rs2113929 chr11:130835974 G/A cg12179176 chr11:130786555 SNX19 0.62 8.79 0.44 8.32e-17 Schizophrenia; CRC trans rs3749237 1.000 rs6804655 chr3:49738945 C/T cg21659725 chr3:3221576 CRBN 0.57 7.99 0.4 2.26e-14 Resting heart rate; CRC cis rs7937682 0.556 rs7108048 chr11:111352299 T/C cg09085632 chr11:111637200 PPP2R1B 0.43 5.82 0.31 1.37e-8 Primary sclerosing cholangitis; CRC cis rs10504229 0.683 rs35840293 chr8:58117634 C/T cg24829409 chr8:58192753 C8orf71 -0.55 -8.03 -0.4 1.71e-14 Developmental language disorder (linguistic errors); CRC cis rs4689388 0.890 rs4342257 chr4:6290037 G/C cg25554036 chr4:6271136 WFS1 0.48 7.63 0.39 2.61e-13 Type 2 diabetes and other traits;Type 2 diabetes; CRC cis rs1552244 1.000 rs7651058 chr3:10066964 C/T cg08888203 chr3:10149979 C3orf24 0.69 9.6 0.47 2.11e-19 Alzheimer's disease; CRC cis rs2836974 0.965 rs34578707 chr21:40675167 G/A cg07074390 chr21:40555500 PSMG1 -0.45 -6.11 -0.32 2.78e-9 Cognitive function; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg13009927 chr2:242254519 SEPT2;HDLBP 0.44 6.92 0.36 2.35e-11 Liver disease severity in Alagille syndrome; CRC cis rs9837602 1.000 rs6802422 chr3:99778655 C/T cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G -0.49 -5.75 -0.3 2.02e-8 Breast cancer; CRC trans rs12599106 0.792 rs11648801 chr16:34360980 C/T cg15383120 chr6:291909 DUSP22 -0.51 -7.13 -0.37 6.35e-12 Menopause (age at onset); CRC cis rs35883536 0.626 rs80052576 chr1:101039229 A/G cg06223162 chr1:101003688 GPR88 -0.36 -6.54 -0.34 2.34e-10 Monocyte count; CRC cis rs10504229 0.683 rs16921831 chr8:58111142 G/A cg24829409 chr8:58192753 C8orf71 -0.55 -7.9 -0.4 4.11e-14 Developmental language disorder (linguistic errors); CRC cis rs3823572 0.542 rs10269665 chr7:133630418 A/G cg03336402 chr7:133662267 EXOC4 0.65 10.09 0.49 4.72e-21 Intelligence (multi-trait analysis); CRC trans rs61931739 0.534 rs10844791 chr12:34211659 C/T cg26384229 chr12:38710491 ALG10B 0.54 6.87 0.35 3.29e-11 Morning vs. evening chronotype; CRC cis rs832540 0.603 rs6870175 chr5:56093371 A/G cg18230493 chr5:56204884 C5orf35 -0.4 -5.81 -0.3 1.51e-8 Coronary artery disease; CRC cis rs523522 0.962 rs7471 chr12:120941215 T/C cg27279351 chr12:120934652 DYNLL1 0.78 11.48 0.53 7.05e-26 High light scatter reticulocyte count; CRC cis rs9916302 0.904 rs620686 chr17:37453617 A/G cg00129232 chr17:37814104 STARD3 0.55 8.26 0.41 3.49e-15 Glomerular filtration rate (creatinine); CRC cis rs172166 0.694 rs203893 chr6:28062066 C/A cg15786705 chr6:28176104 NA 0.63 9.0 0.44 1.81e-17 Cardiac Troponin-T levels; CRC cis rs12983728 0.831 rs35081008 chr19:58662235 C/T cg08687515 chr19:58661962 ZNF329 0.8 8.74 0.43 1.23e-16 Cholesterol, total; CRC cis rs10946940 0.965 rs62401383 chr6:27564547 C/T cg25164649 chr6:28176230 NA -0.41 -5.77 -0.3 1.82e-8 Systemic lupus erythematosus; CRC cis rs9443645 0.901 rs1027813 chr6:79552118 G/T cg05283184 chr6:79620031 NA 0.55 8.82 0.44 6.6e-17 Intelligence (multi-trait analysis); CRC cis rs7591163 0.883 rs16824023 chr2:228720877 G/A cg14646075 chr2:228736089 WDR69 -0.42 -6.07 -0.32 3.43e-9 Blood pressure; CRC cis rs7618501 1.000 rs57648519 chr3:49813169 C/A cg24308560 chr3:49941425 MST1R -0.46 -7.23 -0.37 3.51e-12 Intelligence (multi-trait analysis); CRC cis rs6752107 0.782 rs12692254 chr2:234161211 A/T cg07618928 chr2:234183455 ATG16L1;SCARNA5 0.66 11.29 0.53 3.33e-25 Crohn's disease;Inflammatory bowel disease; CRC cis rs7945705 0.747 rs2742480 chr11:8993130 A/G cg14711859 chr11:8959438 ASCL3 0.38 6.37 0.33 6.45e-10 Hemoglobin concentration; CRC cis rs12893668 0.667 rs8017628 chr14:104047428 C/T cg08213375 chr14:104286397 PPP1R13B 0.34 5.67 0.3 3.19e-8 Reticulocyte count; CRC cis rs11098499 0.909 rs10017335 chr4:120381523 C/G cg09307838 chr4:120376055 NA -0.7 -10.58 -0.5 1.06e-22 Corneal astigmatism; CRC cis rs728616 0.681 rs35014047 chr10:81912397 A/C cg05935833 chr10:81318306 SFTPA2 -0.49 -5.85 -0.31 1.21e-8 Chronic obstructive pulmonary disease-related biomarkers; CRC trans rs10838798 0.563 rs4752902 chr11:48148779 G/A cg21153622 chr11:89784906 NA -0.43 -6.76 -0.35 6.4e-11 Height; CRC cis rs172166 0.516 rs2021826 chr6:28132756 G/A cg15786705 chr6:28176104 NA 0.48 7.18 0.37 4.74e-12 Cardiac Troponin-T levels; CRC cis rs13191362 1.000 rs34714518 chr6:163080778 G/A cg21926612 chr6:163149169 PACRG;PARK2 0.97 12.62 0.57 4.78e-30 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs853679 0.517 rs9380061 chr6:28132803 T/C cg06470822 chr6:28175283 NA 1.03 13.59 0.6 1.04e-33 Depression; CRC cis rs9929218 0.551 rs2274239 chr16:68725783 G/A cg01251360 chr16:68772225 CDH1 -0.24 -5.85 -0.31 1.18e-8 Colorectal cancer; CRC cis rs2243480 1.000 rs709607 chr7:65449541 C/G cg25985355 chr7:65971099 NA 0.47 5.98 0.31 5.87e-9 Diabetic kidney disease; CRC cis rs10504229 1.000 rs67546820 chr8:58168567 G/A cg21724239 chr8:58056113 NA 0.39 5.83 0.31 1.29e-8 Developmental language disorder (linguistic errors); CRC cis rs10911232 0.507 rs10797829 chr1:183033228 C/T ch.1.3577855R chr1:183094577 LAMC1 -0.84 -14.71 -0.63 5.62e-38 Hypertriglyceridemia; CRC cis rs7811142 1.000 rs60844404 chr7:100080474 A/T cg00814883 chr7:100076585 TSC22D4 -0.74 -9.4 -0.46 9.54e-19 Platelet count; CRC cis rs4713118 0.869 rs6902689 chr6:27709441 C/T cg19041857 chr6:27730383 NA -0.43 -6.11 -0.32 2.85e-9 Parkinson's disease; CRC cis rs2811415 0.597 rs2304018 chr3:127779306 G/A cg13719885 chr3:127795394 NA -0.39 -5.95 -0.31 6.69e-9 Lung function (FEV1/FVC); CRC cis rs7412746 0.571 rs12402939 chr1:150615094 A/C cg15448220 chr1:150897856 SETDB1 0.51 7.27 0.37 2.63e-12 Melanoma; CRC cis rs736408 0.570 rs11130327 chr3:52793239 A/G cg18404041 chr3:52824283 ITIH1 -0.45 -9.19 -0.45 4.61e-18 Bipolar disorder; CRC cis rs6426558 0.537 rs648877 chr1:227283614 A/G cg10327440 chr1:227177885 CDC42BPA 0.45 6.66 0.34 1.13e-10 Neutrophil percentage of white cells; CRC cis rs8017423 0.647 rs4904674 chr14:90817412 G/A cg14092571 chr14:90743983 NA 0.38 5.86 0.31 1.12e-8 Mortality in heart failure; CRC cis rs7762018 1.000 rs4509126 chr6:170068058 A/G cg17545662 chr6:170176663 C6orf70 0.53 5.82 0.31 1.39e-8 Thiazide-induced adverse metabolic effects in hypertensive patients; CRC trans rs7937682 0.924 rs11213968 chr11:111527629 G/C cg18187862 chr3:45730750 SACM1L 0.47 6.8 0.35 4.89e-11 Primary sclerosing cholangitis; CRC cis rs6951245 1.000 rs118059236 chr7:1073202 A/C cg20603222 chr7:1096387 C7orf50;GPR146 -0.69 -8.1 -0.41 1.07e-14 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs2304069 0.954 rs2340463 chr5:149409294 C/T cg22760475 chr5:149380129 HMGXB3;TIGD6 0.84 9.37 0.46 1.16e-18 HIV-1 control; CRC cis rs713477 0.935 rs7147968 chr14:55909040 G/A cg13175173 chr14:55914753 NA -0.52 -9.85 -0.48 3.19e-20 Pediatric bone mineral content (femoral neck); CRC trans rs12599106 0.648 rs12447240 chr16:34928236 C/T cg05064044 chr6:292385 DUSP22 0.73 10.49 0.5 2.15e-22 Menopause (age at onset); CRC cis rs10927875 0.541 rs1739841 chr1:16342727 A/G cg10494257 chr1:16342123 HSPB7 0.45 6.27 0.33 1.1e-9 Dilated cardiomyopathy; CRC cis rs595018 0.505 rs11230501 chr11:60598075 G/A cg23904249 chr11:60608951 CCDC86 -0.51 -6.82 -0.35 4.3e-11 Wegener's granulomatosis; CRC cis rs12701220 0.894 rs8591 chr7:1036799 C/T cg26769984 chr7:1090371 C7orf50 0.64 8.89 0.44 4.23e-17 Bronchopulmonary dysplasia; CRC cis rs4304924 0.500 rs7339081 chr13:79235501 A/G cg01819759 chr13:79234251 RNF219 0.4 5.94 0.31 7.21e-9 Large artery stroke; CRC cis rs2386661 0.516 rs61832676 chr10:5646337 G/A cg17085576 chr10:5658249 NA -0.42 -5.89 -0.31 9.39e-9 Breast cancer; CRC cis rs4713118 0.868 rs742047 chr6:27739380 A/G cg03623178 chr6:28175578 NA 0.75 8.36 0.42 1.77e-15 Parkinson's disease; CRC cis rs6062302 0.522 rs3787107 chr20:62230576 G/A cg09650180 chr20:62225654 GMEB2 -0.5 -6.67 -0.35 1.07e-10 Glioblastoma; CRC trans rs1572438 0.619 rs36078286 chr6:866752 T/G cg01563465 chr5:72512441 NA 0.31 6.02 0.31 4.58e-9 Aging; CRC cis rs6558530 0.799 rs62477060 chr8:1706498 A/T cg19131313 chr8:1704013 NA -0.45 -6.25 -0.33 1.28e-9 Systolic blood pressure; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg04371633 chr14:65381025 CHURC1 0.51 6.62 0.34 1.43e-10 Thyroid stimulating hormone; CRC cis rs200895692 1 rs200895692 chr1:43421956 CGCCTGTAATCCCAG/C cg12656391 chr1:43425156 SLC2A1 -0.45 -6.3 -0.33 9.72e-10 Monocyte count; CRC cis rs10170846 0.789 rs972650 chr2:223520287 C/T cg25565276 chr2:223520875 FARSB 0.47 6.23 0.32 1.45e-9 Schizophrenia (inflammation and infection response interaction); CRC cis rs10752881 0.901 rs10911201 chr1:183001622 G/T ch.1.3577855R chr1:183094577 LAMC1 0.86 14.9 0.63 1.01e-38 Colorectal cancer; CRC cis rs9322193 0.884 rs62439836 chr6:149990309 A/G cg07701084 chr6:150067640 NUP43 0.56 8.23 0.41 4.29e-15 Lung cancer; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg01485046 chr19:46498389 CCDC61 0.49 6.92 0.36 2.39e-11 Response to antipsychotic treatment; CRC trans rs1455244 0.700 rs7229302 chr18:11508904 G/T cg00629941 chr15:75287862 SCAMP5 0.43 6.54 0.34 2.38e-10 Schizophrenia; CRC cis rs4664308 0.935 rs6744567 chr2:160933781 C/G cg03641300 chr2:160917029 PLA2R1 -0.73 -11.52 -0.54 5e-26 Idiopathic membranous nephropathy; CRC cis rs10752881 0.967 rs4652758 chr1:182975100 T/C ch.1.3577855R chr1:183094577 LAMC1 0.85 14.67 0.63 7.57e-38 Colorectal cancer; CRC cis rs9896933 0.830 rs113051447 chr17:80791806 A/G cg02398342 chr17:80708632 TBCD;FN3K 0.5 6.45 0.34 3.89e-10 Bone mineral accretion in asthma (oral corticosteroid dose interaction); CRC cis rs9902453 0.612 rs2617868 chr17:28073247 C/T cg26525008 chr17:28256777 EFCAB5;SSH2 -0.72 -12.08 -0.55 4.56e-28 Coffee consumption (cups per day); CRC trans rs629535 0.734 rs659430 chr8:70009988 A/G cg21567404 chr3:27674614 NA 0.72 11.59 0.54 2.83e-26 Dupuytren's disease; CRC cis rs9584850 0.609 rs7983408 chr13:99155593 G/C cg07423050 chr13:99094983 FARP1 0.46 5.67 0.3 3.09e-8 Neuroticism; CRC cis rs4722166 0.630 rs6461667 chr7:22796743 A/G cg26061582 chr7:22766209 IL6 0.54 8.15 0.41 7.51e-15 Lung cancer; CRC cis rs35146811 0.659 rs863450 chr7:99821685 C/T cg13334819 chr7:99746414 C7orf59 0.56 7.27 0.37 2.61e-12 Coronary artery disease; CRC cis rs9914988 0.559 rs1109024 chr17:27189971 C/T cg16670446 chr17:27188758 MIR451;MIR144 -0.6 -10.42 -0.5 3.64e-22 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs2549003 1.000 rs2548997 chr5:131835395 C/T cg02551604 chr5:131831745 NA 0.65 10.36 0.5 6.11e-22 Asthma (sex interaction); CRC cis rs1799949 1.000 rs8176145 chr17:41249094 A/G cg01879757 chr17:41196368 BRCA1 -0.43 -6.48 -0.34 3.32e-10 Menopause (age at onset); CRC cis rs8105895 0.935 rs10406653 chr19:22238023 C/T cg02657401 chr19:22469223 NA -0.34 -5.65 -0.3 3.56e-8 Body mass index (change over time); CRC cis rs4665809 1.000 rs1550381 chr2:26266946 A/G cg27170947 chr2:26402098 FAM59B -0.44 -5.81 -0.3 1.51e-8 Gut microbiome composition (summer); CRC cis rs2050392 0.590 rs17547917 chr10:30718303 G/A cg25182066 chr10:30743637 MAP3K8 -0.46 -6.18 -0.32 1.92e-9 Inflammatory bowel disease; CRC cis rs11167764 0.895 rs9324865 chr5:141488792 T/C cg23435118 chr5:141488016 NDFIP1 -0.46 -7.39 -0.38 1.18e-12 Crohn's disease; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg21054179 chr12:49412581 PRKAG1 0.39 6.16 0.32 2.15e-9 Intelligence (multi-trait analysis); CRC cis rs13256369 0.950 rs13270006 chr8:8574197 C/A cg18904891 chr8:8559673 CLDN23 0.5 6.89 0.35 2.92e-11 Obesity-related traits; CRC cis rs7487075 0.820 rs7135897 chr12:46698902 C/T cg22049899 chr12:47219821 SLC38A4 -0.31 -5.86 -0.31 1.14e-8 Itch intensity from mosquito bite; CRC cis rs6570726 0.818 rs9390338 chr6:145908265 A/G cg05347473 chr6:146136440 FBXO30 0.38 5.72 0.3 2.37e-8 Lobe attachment (rater-scored or self-reported); CRC cis rs514406 0.929 rs557920 chr1:53338757 C/A cg27535305 chr1:53392650 SCP2 -0.39 -6.9 -0.36 2.65e-11 Monocyte count; CRC cis rs45509595 0.841 rs401754 chr6:27782538 T/A cg03623178 chr6:28175578 NA 0.78 6.64 0.34 1.27e-10 Breast cancer; CRC cis rs13161895 0.646 rs75894617 chr5:179499854 G/C cg02702477 chr5:179499311 RNF130 0.92 8.11 0.41 1e-14 LDL cholesterol; CRC cis rs7412746 0.571 rs12402939 chr1:150615094 A/C cg10589385 chr1:150898437 SETDB1 0.32 6.75 0.35 6.57e-11 Melanoma; CRC cis rs6951245 0.580 rs77101766 chr7:1122438 A/G cg07217954 chr7:1067459 C7orf50 0.5 5.87 0.31 1.04e-8 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs6762 0.748 rs1130719 chr11:838760 T/A cg03116740 chr11:841335 TSPAN4;POLR2L -0.42 -7.05 -0.36 1.08e-11 Mean platelet volume; CRC cis rs2386661 0.826 rs4749834 chr10:5671808 G/A cg26603656 chr10:5671107 NA 0.54 8.92 0.44 3.41e-17 Breast cancer; CRC cis rs10504229 1.000 rs1961778 chr8:58168756 G/A cg02290350 chr8:58132656 NA -0.41 -6.08 -0.32 3.25e-9 Developmental language disorder (linguistic errors); CRC cis rs2976388 0.525 rs2016749 chr8:143836118 G/A cg04969067 chr8:143858791 LYNX1 -0.61 -10.59 -0.5 9.91e-23 Urinary tract infection frequency; CRC cis rs5753618 0.561 rs9606831 chr22:31732512 C/T cg07713946 chr22:31675144 LIMK2 0.4 5.82 0.31 1.37e-8 Colorectal cancer; CRC cis rs17345786 1.000 rs73863360 chr3:101316837 G/A cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.58 6.84 0.35 3.76e-11 Colonoscopy-negative controls vs population controls; CRC cis rs4423214 0.879 rs1790345 chr11:71145941 G/A cg13043300 chr11:71146211 DHCR7 -0.44 -6.02 -0.31 4.68e-9 Vitamin D levels; CRC cis rs765787 0.530 rs2554457 chr15:45520926 G/A cg24006582 chr15:45444508 DUOX1 -0.56 -8.42 -0.42 1.22e-15 Uric acid levels; CRC cis rs3820068 0.608 rs12092485 chr1:16048038 A/G cg13390004 chr1:15929781 NA 0.42 5.82 0.31 1.36e-8 Systolic blood pressure; CRC cis rs67311347 1.000 rs28491638 chr3:40496263 T/C cg09455208 chr3:40491958 NA 0.47 8.97 0.44 2.3e-17 Renal cell carcinoma; CRC cis rs1799949 1.000 rs11655505 chr17:41278377 G/A cg01879757 chr17:41196368 BRCA1 -0.43 -6.61 -0.34 1.54e-10 Menopause (age at onset); CRC cis rs10986311 0.775 rs10986324 chr9:127121825 T/C cg14243010 chr9:127117328 LOC100129034;PSMB7 0.41 6.17 0.32 2.06e-9 Vitiligo; CRC trans rs12478296 0.892 rs60545379 chr2:243034390 A/T cg18288967 chr1:45987694 PRDX1 0.69 7.67 0.39 1.99e-13 Obesity-related traits; CRC cis rs12476592 0.602 rs7570031 chr2:63792265 A/G cg10828910 chr2:63850056 LOC388955 0.47 5.79 0.3 1.62e-8 Childhood ear infection; CRC trans rs783540 0.934 rs803747 chr15:83258096 A/G cg18393722 chr15:85113863 UBE2QP1 -0.37 -6.32 -0.33 8.45e-10 Schizophrenia; CRC cis rs6952808 0.636 rs73048162 chr7:1949328 T/C cg02951883 chr7:2050386 MAD1L1 -0.54 -8.71 -0.43 1.53e-16 Bipolar disorder and schizophrenia; CRC cis rs10876993 0.890 rs12302351 chr12:58062590 T/C cg18357645 chr12:58087776 OS9 0.56 7.69 0.39 1.77e-13 Celiac disease or Rheumatoid arthritis; CRC cis rs6831352 0.918 rs34876213 chr4:100062216 G/A cg13256891 chr4:100009986 ADH5 -0.65 -8.73 -0.43 1.31e-16 Alcohol dependence; CRC cis rs736408 0.648 rs3774354 chr3:52817675 G/A cg15147215 chr3:52552868 STAB1 -0.59 -9.2 -0.45 4.14e-18 Bipolar disorder; CRC cis rs7216064 1.000 rs1976053 chr17:65833002 C/G cg12091567 chr17:66097778 LOC651250 -0.63 -7.88 -0.4 4.7e-14 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CRC cis rs4481887 0.720 rs4543835 chr1:248468608 A/T cg00666640 chr1:248458726 OR2T12 0.52 9.07 0.45 1.11e-17 Common traits (Other); CRC cis rs4713118 0.869 rs6901520 chr6:27714575 G/T cg19041857 chr6:27730383 NA -0.41 -5.99 -0.31 5.45e-9 Parkinson's disease; CRC cis rs9916302 0.904 rs4794813 chr17:37670994 A/T cg03013999 chr17:37608204 MED1 0.42 6.38 0.33 5.84e-10 Glomerular filtration rate (creatinine); CRC cis rs7312933 0.558 rs61926593 chr12:42818912 C/T cg11827402 chr12:42719852 PPHLN1;ZCRB1 0.67 9.67 0.47 1.22e-19 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CRC cis rs7666738 0.830 rs1967979 chr4:98966201 G/T cg17366294 chr4:99064904 C4orf37 0.43 7.36 0.38 1.49e-12 Colonoscopy-negative controls vs population controls; CRC cis rs11971779 0.680 rs6962637 chr7:139051350 G/A cg07862535 chr7:139043722 LUC7L2 0.57 7.35 0.38 1.61e-12 Diisocyanate-induced asthma; CRC cis rs4237845 0.591 rs4760344 chr12:58320783 A/T cg00677455 chr12:58241039 CTDSP2 0.47 6.3 0.33 9.49e-10 Intelligence (multi-trait analysis); CRC trans rs916888 0.531 rs183211 chr17:44788310 G/A cg07870213 chr5:140052090 DND1 0.64 8.11 0.41 9.98e-15 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs8014204 0.533 rs12434646 chr14:75178693 C/T cg03030879 chr14:75389066 RPS6KL1 -0.4 -6.42 -0.33 4.83e-10 Caffeine consumption; CRC cis rs2795502 1.000 rs2185717 chr10:43343875 G/A cg20628663 chr10:43360327 NA 0.68 10.71 0.51 3.57e-23 Blood protein levels; CRC cis rs4713118 0.614 rs9468209 chr6:27694421 C/T cg03623178 chr6:28175578 NA 0.54 7.81 0.4 7.96e-14 Parkinson's disease; CRC cis rs11190604 1.000 rs10883500 chr10:102238324 T/G cg16342193 chr10:102329863 NA -0.36 -5.86 -0.31 1.14e-8 Palmitoleic acid (16:1n-7) levels; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg14489649 chr17:40021376 KLHL11 0.42 5.98 0.31 5.75e-9 Intelligence (multi-trait analysis); CRC cis rs8060686 0.920 rs73591976 chr16:67811590 C/A cg26727032 chr16:67993705 SLC12A4 -0.6 -6.97 -0.36 1.69e-11 HDL cholesterol;Metabolic syndrome; CRC cis rs2882667 0.858 rs4643949 chr5:138372345 C/T cg04439458 chr5:138467593 SIL1 -0.33 -5.98 -0.31 5.96e-9 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs10504229 0.638 rs7826839 chr8:58132075 G/T cg21724239 chr8:58056113 NA 0.49 6.81 0.35 4.75e-11 Developmental language disorder (linguistic errors); CRC cis rs8077889 0.619 rs1230399 chr17:41845403 C/T cg26893861 chr17:41843967 DUSP3 -1.11 -22.53 -0.78 1.21e-68 Triglycerides; CRC cis rs9435341 0.965 rs2335104 chr1:107583641 A/T cg11070056 chr1:107600091 PRMT6 0.37 5.75 0.3 2.05e-8 Facial morphology (factor 21, depth of nasal alae); CRC cis rs9818758 0.607 rs13068038 chr3:49294250 C/A cg07636037 chr3:49044803 WDR6 -0.71 -6.09 -0.32 3.2e-9 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; CRC cis rs12130219 0.500 rs1552991 chr1:152165878 C/T cg26879891 chr1:152191343 HRNR -0.31 -5.84 -0.31 1.27e-8 Inflammatory skin disease; CRC cis rs1799949 1.000 rs1399323 chr17:41332330 T/C cg05368731 chr17:41323189 NBR1 0.68 10.42 0.5 3.68e-22 Menopause (age at onset); CRC trans rs9583531 0.657 rs9521915 chr13:111384528 C/T cg20064139 chr20:41823021 NA -0.3 -6.26 -0.33 1.21e-9 Coronary artery disease; CRC cis rs7954584 0.604 rs34159444 chr12:122416667 A/G cg21171335 chr12:122356390 WDR66 0.39 5.97 0.31 6.24e-9 Mean corpuscular volume; CRC cis rs7937682 0.961 rs4935790 chr11:111633014 T/C cg09085632 chr11:111637200 PPP2R1B 1.06 20.83 0.75 4.82e-62 Primary sclerosing cholangitis; CRC cis rs3733585 0.579 rs4235353 chr4:10122934 C/T cg00071950 chr4:10020882 SLC2A9 -0.56 -8.78 -0.44 8.82e-17 Cleft plate (environmental tobacco smoke interaction); CRC cis rs7932354 0.528 rs10838660 chr11:47152273 C/T cg19486271 chr11:47235900 DDB2 -0.49 -7.37 -0.38 1.35e-12 Bone mineral density (hip);Bone mineral density; CRC cis rs1046896 0.594 rs9914570 chr17:80783721 C/T cg17346650 chr17:80929145 B3GNTL1 0.48 7.06 0.36 9.69e-12 Glycated hemoglobin levels; CRC trans rs7267979 0.966 rs3827014 chr20:25371559 C/T cg17903999 chr18:56338584 MALT1 0.42 6.92 0.36 2.31e-11 Liver enzyme levels (alkaline phosphatase); CRC cis rs12711979 0.513 rs11676551 chr2:3836782 A/G cg17052675 chr2:3827356 NA -0.35 -5.96 -0.31 6.6e-9 Itch intensity from mosquito bite adjusted by bite size; CRC cis rs2180341 0.538 rs11556354 chr6:127664661 G/A cg27446573 chr6:127587934 RNF146 0.48 6.86 0.35 3.36e-11 Breast cancer; CRC cis rs3096299 0.606 rs8052103 chr16:89541243 A/T cg05320533 chr16:89541815 ANKRD11 0.44 6.13 0.32 2.52e-9 Multiple myeloma (IgH translocation); CRC cis rs2013441 0.670 rs4924802 chr17:19955895 G/T cg13482628 chr17:19912719 NA 0.41 5.71 0.3 2.5e-8 Obesity-related traits; CRC cis rs9486715 1.000 rs7752277 chr6:97065131 C/T cg06623918 chr6:96969491 KIAA0776 -0.91 -15.73 -0.66 5.53e-42 Headache; CRC cis rs9443645 0.869 rs9443621 chr6:79576499 A/G cg05283184 chr6:79620031 NA -0.57 -9.13 -0.45 6.94e-18 Intelligence (multi-trait analysis); CRC cis rs7493 1.000 rs6961773 chr7:95037718 T/G cg17330251 chr7:94953956 PON1 -0.59 -7.62 -0.39 2.69e-13 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs12681287 0.547 rs7465511 chr8:87521481 C/T cg27223183 chr8:87520930 FAM82B -0.56 -7.69 -0.39 1.68e-13 Caudate activity during reward; CRC cis rs10191773 0.589 rs72831634 chr2:112946796 A/G cg24977338 chr2:113188963 RGPD8;RGPD5 -0.66 -5.75 -0.3 2.07e-8 Yeast infection; CRC cis rs365302 0.904 rs392551 chr6:159650174 C/T cg14500486 chr6:159655392 FNDC1 0.44 6.82 0.35 4.31e-11 Coronary heart disease; CRC cis rs7523050 0.643 rs35526993 chr1:109405107 A/T cg08274380 chr1:109419600 GPSM2 0.86 6.9 0.36 2.74e-11 Fat distribution (HIV); CRC cis rs116095464 0.619 rs2303741 chr5:218356 T/C cg22857025 chr5:266934 NA -1.23 -16.9 -0.68 1.4300000000000001e-46 Breast cancer; CRC cis rs7726839 0.540 rs12517638 chr5:645484 C/T cg09021430 chr5:549028 NA -0.72 -8.15 -0.41 7.69e-15 Obesity-related traits; CRC cis rs7618915 0.547 rs8906 chr3:52739520 T/C cg05573699 chr3:52720067 GNL3;PBRM1 -0.44 -6.14 -0.32 2.36e-9 Bipolar disorder; CRC cis rs4481887 0.676 rs946761 chr1:248521032 T/C cg26353448 chr1:248524236 OR2T4 -0.34 -6.87 -0.35 3.15e-11 Common traits (Other); CRC cis rs9303280 0.840 rs12939457 chr17:38032188 T/C cg11212589 chr17:38028394 ZPBP2 0.43 7.97 0.4 2.71e-14 Self-reported allergy; CRC cis rs7618915 0.547 rs2268027 chr3:52766606 G/A cg05573699 chr3:52720067 GNL3;PBRM1 -0.44 -6.15 -0.32 2.23e-9 Bipolar disorder; CRC cis rs1728785 1.000 rs1728764 chr16:68572292 G/C cg02972257 chr16:68554789 NA -0.58 -7.15 -0.37 5.78e-12 Ulcerative colitis; CRC cis rs7618915 0.501 rs7624716 chr3:52751534 T/C cg15147215 chr3:52552868 STAB1 -0.63 -10.57 -0.5 1.14e-22 Bipolar disorder; CRC cis rs270601 0.913 rs273899 chr5:131695178 G/A cg11843238 chr5:131593191 PDLIM4 0.43 7.3 0.37 2.22e-12 Acylcarnitine levels; CRC cis rs742320 0.756 rs3765263 chr16:840378 A/G cg07501729 chr16:846077 CHTF18 0.56 8.46 0.42 8.77e-16 Mean corpuscular volume; CRC cis rs7927592 0.913 rs12294029 chr11:68257059 A/C cg01657329 chr11:68192670 LRP5 -0.46 -6.74 -0.35 7.19e-11 Total body bone mineral density; CRC cis rs1150668 0.796 rs1005125 chr6:28367355 G/A cg02683197 chr6:28174875 NA 0.42 5.92 0.31 8.18e-9 Pubertal anthropometrics; CRC cis rs9837602 1.000 rs71313585 chr3:99770696 A/G cg07805332 chr3:99536008 MIR548G;C3orf26 -0.48 -6.33 -0.33 8.1e-10 Breast cancer; CRC cis rs9649213 0.574 rs7794187 chr7:97889758 A/C cg24562669 chr7:97807699 LMTK2 0.51 8.77 0.44 9.65e-17 Prostate cancer (SNP x SNP interaction); CRC cis rs35110281 0.720 rs162376 chr21:44926759 G/T cg04455712 chr21:45112962 RRP1B -0.42 -8.14 -0.41 8.28e-15 Mean corpuscular volume; CRC cis rs78456975 1.000 rs13414537 chr2:1556330 C/T cg01028140 chr2:1542097 TPO -0.57 -5.84 -0.31 1.28e-8 Placebo response in major depressive disorder (% change in symptom score); CRC cis rs4664308 0.870 rs2198918 chr2:161015052 C/T cg03641300 chr2:160917029 PLA2R1 -0.73 -12.12 -0.56 3.22e-28 Idiopathic membranous nephropathy; CRC cis rs938554 0.612 rs13113918 chr4:9998493 A/G cg00071950 chr4:10020882 SLC2A9 0.49 6.84 0.35 3.78e-11 Blood metabolite levels; CRC cis rs4654899 1.000 rs10799686 chr1:21486445 A/T cg02927042 chr1:21476669 EIF4G3 0.45 7.22 0.37 3.56e-12 Superior frontal gyrus grey matter volume; CRC cis rs55788414 0.932 rs9921666 chr16:81181669 T/C cg06400318 chr16:81190750 PKD1L2 -0.59 -6.78 -0.35 5.73e-11 Left ventricular obstructive tract defect (maternal effect); CRC cis rs10791323 0.604 rs2723605 chr11:133711241 C/G cg15485101 chr11:133734466 NA 0.45 7.93 0.4 3.52e-14 Childhood ear infection; CRC trans rs7151302 0.749 rs243305 chr14:33738476 C/G cg15822049 chr14:91338889 RPS6KA5 0.5 5.96 0.31 6.4e-9 Plasma amyloid beta peptide concentrations (ABx-40); CRC cis rs12024301 0.557 rs12028474 chr1:183643542 T/C cg11505048 chr1:183622726 RGL1;APOBEC4 0.81 7.06 0.36 1.01e-11 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs4290604 0.748 rs62183336 chr2:237962784 C/G cg23555395 chr2:238036564 NA 0.57 5.82 0.31 1.43e-8 Asthma; CRC cis rs2991971 0.967 rs60608374 chr1:46008913 G/A cg24296786 chr1:45957014 TESK2 0.57 8.63 0.43 2.6e-16 High light scatter reticulocyte count; CRC cis rs6502050 0.835 rs56232956 chr17:80078929 C/T cg19223190 chr17:80058835 NA -0.39 -6.09 -0.32 3.17e-9 Life satisfaction; CRC cis rs17270561 0.609 rs7746502 chr6:25718762 T/A cg16482183 chr6:26056742 HIST1H1C -0.64 -8.61 -0.43 3.02e-16 Iron status biomarkers; CRC cis rs727505 0.754 rs56012154 chr7:124781250 A/G cg23710748 chr7:124431027 NA -0.68 -11.62 -0.54 2.1e-26 Lewy body disease; CRC cis rs6502050 0.723 rs11657069 chr17:80083809 C/T cg13198984 chr17:80129470 CCDC57 -0.48 -8.56 -0.43 4.49e-16 Life satisfaction; CRC cis rs8180040 0.967 rs17411375 chr3:47395135 C/T cg10298567 chr3:47292165 KIF9 0.43 7.08 0.36 8.79e-12 Colorectal cancer; CRC cis rs734999 0.549 rs2764840 chr1:2529437 C/T cg20673091 chr1:2541236 MMEL1 -0.36 -5.82 -0.31 1.39e-8 Ulcerative colitis; CRC cis rs2933343 0.729 rs6767104 chr3:128648117 G/T cg11901034 chr3:128598214 ACAD9 0.57 8.0 0.4 2.12e-14 IgG glycosylation; CRC cis rs2072499 0.833 rs2251636 chr1:156202809 G/C cg25208724 chr1:156163844 SLC25A44 0.98 20.18 0.74 1.73e-59 Testicular germ cell tumor; CRC cis rs796364 0.951 rs11680258 chr2:200996976 T/C cg23649088 chr2:200775458 C2orf69 -0.57 -6.34 -0.33 7.48e-10 Schizophrenia; CRC cis rs2243480 1.000 rs316326 chr7:65609453 T/C cg12463550 chr7:65579703 CRCP 0.7 6.45 0.34 3.98e-10 Diabetic kidney disease; CRC cis rs2739330 0.791 rs4822458 chr22:24265659 C/T cg09033563 chr22:24373618 LOC391322 -0.45 -6.46 -0.34 3.87e-10 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs9911578 1.000 rs2567905 chr17:56782297 T/C cg05425664 chr17:57184151 TRIM37 -0.5 -7.93 -0.4 3.41e-14 Intelligence (multi-trait analysis); CRC cis rs597539 0.616 rs631001 chr11:68642974 C/T cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.87 13.85 0.61 1.14e-34 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs4664293 0.867 rs6432553 chr2:160577010 A/G cg08347373 chr2:160653686 CD302 -0.47 -7.43 -0.38 9.57e-13 Monocyte percentage of white cells; CRC cis rs6893300 0.524 rs12374446 chr5:179131143 A/G cg14593053 chr5:179126677 CANX 0.49 7.7 0.39 1.66e-13 Resting heart rate; CRC cis rs250677 0.687 rs3095947 chr5:148436728 T/C cg18129178 chr5:148520854 ABLIM3 -0.36 -5.67 -0.3 3.2e-8 Breast cancer; CRC cis rs7726839 0.540 rs72703092 chr5:599269 G/A cg09021430 chr5:549028 NA -0.73 -8.33 -0.42 2.19e-15 Obesity-related traits; CRC cis rs7769051 1.000 rs12203977 chr6:133122760 A/G cg22852734 chr6:133119734 C6orf192 0.98 12.25 0.56 1.12e-28 Type 2 diabetes nephropathy; CRC cis rs727505 1.000 rs28702851 chr7:124442991 G/A cg23710748 chr7:124431027 NA -0.83 -14.31 -0.62 1.94e-36 Lewy body disease; CRC cis rs875971 0.862 rs6955837 chr7:66043142 C/T cg00343986 chr7:65444356 GUSB -0.45 -6.3 -0.33 9.71e-10 Aortic root size; CRC cis rs172166 0.637 rs1225592 chr6:28150242 G/A cg06470822 chr6:28175283 NA 0.84 13.01 0.58 1.61e-31 Cardiac Troponin-T levels; CRC cis rs9372498 0.536 rs62422229 chr6:118959288 T/C cg01339444 chr6:118972232 C6orf204 0.53 5.87 0.31 1.07e-8 Diastolic blood pressure; CRC cis rs9443645 0.901 rs56057971 chr6:79607182 G/A cg05283184 chr6:79620031 NA -0.58 -9.24 -0.45 3.18e-18 Intelligence (multi-trait analysis); CRC cis rs6662572 0.737 rs72692603 chr1:46378838 T/C cg08644498 chr1:46502608 NA 0.43 6.65 0.34 1.2e-10 Blood protein levels; CRC cis rs367615 0.661 rs9326775 chr5:108836925 A/T cg17395555 chr5:108820864 NA 0.46 9.44 0.46 7.13e-19 Colorectal cancer (SNP x SNP interaction); CRC cis rs3849570 0.696 rs13092157 chr3:81875332 T/A cg07356753 chr3:81810745 GBE1 -0.62 -8.4 -0.42 1.4e-15 Waist circumference;Body mass index; CRC cis rs7666738 0.830 rs10007261 chr4:98926155 C/T cg17366294 chr4:99064904 C4orf37 0.43 7.32 0.37 1.95e-12 Colonoscopy-negative controls vs population controls; CRC cis rs2976388 0.609 rs2572904 chr8:143792193 A/C cg24046110 chr8:143859143 LYNX1 0.49 8.61 0.43 3.15e-16 Urinary tract infection frequency; CRC cis rs2840044 1.000 rs17637907 chr17:33891386 A/G cg05299278 chr17:33885742 SLFN14 -0.43 -6.5 -0.34 3.05e-10 Response to radiotherapy in cancer (late toxicity); CRC cis rs4148883 0.713 rs3828541 chr4:100042262 A/G cg12011299 chr4:100065546 ADH4 0.48 10.71 0.51 3.67e-23 Alcohol dependence; CRC cis rs12497850 0.931 rs7628719 chr3:48995487 C/T cg20833759 chr3:49053208 WDR6;DALRD3 0.48 8.24 0.41 4.17e-15 Parkinson's disease; CRC cis rs10832963 1.000 rs2084220 chr11:18656932 C/T cg20219074 chr11:18656078 SPTY2D1 0.6 8.48 0.42 7.85e-16 Breast cancer; CRC cis rs992157 0.730 rs2382828 chr2:219184492 A/G cg04880052 chr2:219191631 PNKD 0.4 6.08 0.32 3.32e-9 Colorectal cancer; CRC cis rs4819052 0.851 rs2838833 chr21:46665160 C/T cg19498844 chr21:46707878 POFUT2;LOC642852 0.73 10.52 0.5 1.72e-22 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs4865169 0.560 rs1277312 chr4:57902945 T/A cg25525207 chr4:57843836 C4orf14;POLR2B -0.4 -5.63 -0.3 3.89e-8 Breast cancer; CRC cis rs3741404 0.791 rs7102177 chr11:63909228 T/C cg06219103 chr11:63990595 FERMT3 -0.38 -5.73 -0.3 2.29e-8 Platelet count; CRC cis rs17253792 0.822 rs10483645 chr14:56103766 G/T cg01858014 chr14:56050164 KTN1 -0.87 -7.25 -0.37 3.01e-12 Putamen volume; CRC cis rs3617 0.625 rs56019197 chr3:52874753 T/C cg15147215 chr3:52552868 STAB1 0.5 8.63 0.43 2.58e-16 Red blood cell count;Autism spectrum disorder or schizophrenia; CRC cis rs7208859 0.623 rs11652358 chr17:29205480 T/C cg14008862 chr17:28927542 LRRC37B2 0.55 5.74 0.3 2.12e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs8077889 0.917 rs72836545 chr17:41892602 A/G cg16892393 chr17:41919603 NA 0.59 8.51 0.42 6.2e-16 Triglycerides; CRC cis rs17711722 0.503 rs453835 chr7:65511159 T/A cg02869306 chr7:64672164 INTS4L1 0.43 7.01 0.36 1.38e-11 Calcium levels; CRC cis rs17125944 0.505 rs77949716 chr14:53204234 G/A cg00686598 chr14:53173677 PSMC6 1.24 11.52 0.54 5.05e-26 Alzheimer's disease (late onset); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg22108469 chr5:174158984 NA 0.27 6.31 0.33 9.19e-10 Liver disease severity in Alagille syndrome; CRC cis rs6598955 0.627 rs6684875 chr1:26567044 A/G cg04990556 chr1:26633338 UBXN11 0.55 5.91 0.31 8.35e-9 Obesity-related traits; CRC cis rs910316 0.934 rs7141705 chr14:75655352 G/C cg08847533 chr14:75593920 NEK9 -0.85 -14.94 -0.64 7.01e-39 Height; CRC cis rs6460942 1.000 rs75333414 chr7:12303829 T/A cg20607287 chr7:12443886 VWDE -0.54 -5.76 -0.3 1.89e-8 Coronary artery disease; CRC cis rs6496044 0.591 rs979825 chr15:86080625 A/T cg17133734 chr15:86042851 AKAP13 0.42 6.81 0.35 4.68e-11 Interstitial lung disease; CRC cis rs736408 0.509 rs13083798 chr3:52649748 A/G cg15147215 chr3:52552868 STAB1 -0.67 -12.49 -0.57 1.44e-29 Bipolar disorder; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg08377010 chr19:48673515 LIG1 0.44 6.06 0.32 3.64e-9 Anxiety disorder; CRC cis rs6496667 0.779 rs8033512 chr15:90945307 A/T cg04176472 chr15:90893244 GABARAPL3 0.59 7.69 0.39 1.72e-13 Rheumatoid arthritis; CRC cis rs11098499 0.863 rs11947234 chr4:120474859 A/G cg24375607 chr4:120327624 NA 0.48 7.26 0.37 2.84e-12 Corneal astigmatism; CRC cis rs780096 0.526 rs1647267 chr2:27651054 A/T cg17158414 chr2:27665306 KRTCAP3 -0.3 -6.51 -0.34 2.82e-10 Total body bone mineral density; CRC cis rs282587 0.569 rs378491 chr13:113398408 C/A cg04656015 chr13:113407548 ATP11A 0.62 7.97 0.4 2.63e-14 Glycated hemoglobin levels; CRC cis rs72781680 0.716 rs6718631 chr2:24036086 A/G cg08917208 chr2:24149416 ATAD2B -0.55 -6.67 -0.35 1.08e-10 Lymphocyte counts; CRC cis rs4563143 0.514 rs73029076 chr19:29292032 G/T cg12756686 chr19:29218302 NA 0.64 8.72 0.43 1.36e-16 Methadone dose in opioid dependence; CRC trans rs7027930 0.524 rs1962204 chr9:613315 A/G cg27061366 chr19:13044373 FARSA 0.51 6.27 0.33 1.17e-9 Pulmonary function decline; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg05312278 chr15:43803195 TP53BP1 -0.41 -6.21 -0.32 1.59e-9 Myopia (pathological); CRC cis rs9814567 1.000 rs6782563 chr3:134295959 C/T cg06109529 chr3:134205091 CEP63;ANAPC13 0.81 11.69 0.54 1.24e-26 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs875971 0.862 rs2088655 chr7:65795711 T/C cg18876405 chr7:65276391 NA -0.54 -8.67 -0.43 1.96e-16 Aortic root size; CRC cis rs6912958 0.678 rs9450744 chr6:88280529 T/C cg12350822 chr6:88032061 C6orf162;GJB7 -0.34 -6.37 -0.33 6.44e-10 Monocyte percentage of white cells; CRC cis rs7666738 0.830 rs1967977 chr4:98966141 A/G cg05340658 chr4:99064831 C4orf37 0.61 9.45 0.46 6.55e-19 Colonoscopy-negative controls vs population controls; CRC cis rs7769051 0.522 rs73550455 chr6:133096633 A/G cg22852734 chr6:133119734 C6orf192 0.77 6.44 0.33 4.35e-10 Type 2 diabetes nephropathy; CRC cis rs6570726 0.935 rs12663205 chr6:145818378 G/A cg05347473 chr6:146136440 FBXO30 0.37 6.0 0.31 5.27e-9 Lobe attachment (rater-scored or self-reported); CRC trans rs875971 0.660 rs2191268 chr7:66110224 C/T cg21227347 chr9:117374170 C9orf91 -0.39 -6.03 -0.32 4.31e-9 Aortic root size; CRC cis rs3760982 0.585 rs8109812 chr19:44298494 C/A cg11993925 chr19:44307056 LYPD5 0.57 10.18 0.49 2.44e-21 Breast cancer (estrogen-receptor negative);Breast cancer; CRC cis rs4819052 1.000 rs733738 chr21:46666396 A/G cg11663144 chr21:46675770 NA 0.74 10.42 0.5 3.73e-22 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs12541335 0.639 rs7003478 chr8:22201123 A/G cg02463440 chr8:22132932 PIWIL2 0.5 8.68 0.43 1.9e-16 Hypertriglyceridemia; CRC cis rs6499255 1.000 rs1139178 chr16:69781468 T/C cg00738113 chr16:70207722 CLEC18C -0.41 -5.92 -0.31 7.99e-9 IgE levels; CRC cis rs6674176 0.542 rs2906468 chr1:44319007 A/G cg12908607 chr1:44402522 ARTN -0.47 -8.18 -0.41 6.32e-15 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Cognitive ability; CRC trans rs1814175 0.669 rs10839315 chr11:49654406 G/A cg03929089 chr4:120376271 NA -0.73 -11.82 -0.55 4.15e-27 Height; CRC cis rs2292864 0.764 rs36046953 chr17:45381791 A/G cg18085866 chr17:45331354 ITGB3 -0.58 -5.63 -0.3 3.94e-8 Left atrial antero-posterior diameter; CRC cis rs4713118 0.666 rs4140646 chr6:27738801 G/A cg03623178 chr6:28175578 NA 0.75 8.28 0.42 3.23e-15 Parkinson's disease; CRC cis rs2251381 0.722 rs2251278 chr21:30529234 A/G cg24692254 chr21:30365293 RNF160 0.76 12.32 0.56 6.15e-29 Selective IgA deficiency; CRC cis rs9487051 0.676 rs13195816 chr6:109598624 T/C cg12927641 chr6:109611667 NA -0.37 -6.37 -0.33 6.42e-10 Reticulocyte fraction of red cells; CRC cis rs17376456 0.778 rs72786662 chr5:93137630 C/T cg25358565 chr5:93447407 FAM172A 1.0 9.95 0.48 1.49e-20 Diabetic retinopathy; CRC cis rs2404602 0.655 rs4886507 chr15:77209694 T/C cg23625390 chr15:77176239 SCAPER 0.45 6.23 0.32 1.44e-9 Blood metabolite levels; CRC cis rs9894429 1.000 rs7223613 chr17:79574803 C/T cg21984481 chr17:79567631 NPLOC4 0.53 9.8 0.48 4.52e-20 Eye color traits; CRC cis rs62064224 0.589 rs6505295 chr17:30687522 G/C cg18200150 chr17:30822561 MYO1D 0.44 8.58 0.43 3.91e-16 Schizophrenia; CRC trans rs7615952 0.546 rs112919177 chr3:125346070 G/A cg16558177 chr4:4109446 NA -0.56 -6.52 -0.34 2.73e-10 Blood pressure (smoking interaction); CRC cis rs7618501 0.574 rs6765484 chr3:50041313 C/T cg24110177 chr3:50126178 RBM5 0.48 7.51 0.38 5.6e-13 Intelligence (multi-trait analysis); CRC trans rs1814175 0.869 rs10769600 chr11:49681832 C/T cg03929089 chr4:120376271 NA -0.94 -17.32 -0.69 3.32e-48 Height; CRC cis rs1624802 0.967 rs1696432 chr12:130496976 A/G cg15444478 chr12:130494697 NA -0.29 -6.05 -0.32 3.85e-9 Obesity-related traits; CRC cis rs56399783 0.901 rs56007918 chr7:2826205 A/G cg19731401 chr7:2775893 GNA12 0.68 7.36 0.38 1.47e-12 Childhood ear infection; CRC cis rs6502050 0.799 rs9675196 chr17:80096655 C/T cg02741985 chr17:80059408 CCDC57 0.43 7.01 0.36 1.33e-11 Life satisfaction; CRC cis rs990171 1.000 rs1035127 chr2:103019919 C/T cg03938978 chr2:103052716 IL18RAP -0.46 -5.78 -0.3 1.7e-8 Lymphocyte counts; CRC cis rs3858526 0.584 rs10769274 chr11:5866925 T/C cg26762873 chr11:5879799 OR52E8 -0.49 -7.52 -0.38 5.17e-13 DNA methylation (variation); CRC cis rs6912958 0.630 rs4707377 chr6:88280332 C/T cg12350822 chr6:88032061 C6orf162;GJB7 -0.34 -6.37 -0.33 6.44e-10 Monocyte percentage of white cells; CRC cis rs7224685 0.501 rs8066272 chr17:3900528 C/T cg21851534 chr17:3907994 ZZEF1 0.37 6.29 0.33 9.89e-10 Type 2 diabetes; CRC cis rs10992471 0.597 rs11789163 chr9:95234973 T/C cg14631576 chr9:95140430 CENPP -0.32 -6.11 -0.32 2.88e-9 Visceral adipose tissue/subcutaneous adipose tissue ratio; CRC cis rs853679 0.542 rs6934769 chr6:28090931 A/G cg06470822 chr6:28175283 NA 1.0 13.33 0.59 1.06e-32 Depression; CRC trans rs2228479 0.850 rs17226498 chr16:89840631 T/C cg21302420 chr1:112162376 RAP1A 0.72 5.96 0.31 6.33e-9 Skin colour saturation; CRC cis rs60871478 1.000 rs4374882 chr7:821798 C/T cg13844804 chr7:814759 HEATR2 0.6 7.93 0.4 3.45e-14 Cerebrospinal P-tau181p levels; CRC cis rs1865760 0.613 rs7749342 chr6:25920265 T/C cg03517284 chr6:25882590 NA -0.41 -6.07 -0.32 3.47e-9 Height; CRC cis rs34311866 0.808 rs748483 chr4:952409 A/G cg14530993 chr4:882597 GAK 0.73 6.66 0.34 1.14e-10 Parkinson's disease; CRC cis rs9611519 1.000 rs9611519 chr22:41613188 C/T cg03806693 chr22:41940476 POLR3H -0.59 -7.62 -0.39 2.82e-13 Neuroticism; CRC cis rs9372498 0.536 rs9489458 chr6:118920503 G/A cg01339444 chr6:118972232 C6orf204 0.55 6.16 0.32 2.08e-9 Diastolic blood pressure; CRC cis rs847577 0.609 rs7791463 chr7:97819047 G/A cg21770322 chr7:97807741 LMTK2 0.86 19.39 0.73 2.24e-56 Breast cancer; CRC cis rs6867913 0.533 rs252152 chr5:141445774 A/G cg08523384 chr5:141488047 NDFIP1 -0.35 -6.36 -0.33 6.75e-10 Asthma; CRC cis rs853679 0.517 rs9468297 chr6:28118874 G/T cg03623178 chr6:28175578 NA 0.98 12.66 0.57 3.31e-30 Depression; CRC cis rs2153535 0.580 rs2152348 chr6:8474301 C/A cg07606381 chr6:8435919 SLC35B3 0.67 10.79 0.51 1.94e-23 Motion sickness; CRC cis rs35264875 1.000 rs35264875 chr11:68846399 A/T cg01993067 chr11:68851601 TPCN2 0.56 6.29 0.33 1.03e-9 Blond vs. brown hair color; CRC cis rs9399135 0.967 rs6569990 chr6:135365818 C/T cg22676075 chr6:135203613 NA 0.38 5.86 0.31 1.11e-8 Red blood cell count; CRC cis rs3789045 0.826 rs12040520 chr1:204564762 G/A cg17419461 chr1:204415978 PIK3C2B -0.5 -7.03 -0.36 1.22e-11 Educational attainment (college completion); CRC cis rs7552404 0.924 rs1146574 chr1:76202671 A/G cg22875332 chr1:76189707 ACADM 0.69 10.51 0.5 1.78e-22 Blood metabolite levels;Acylcarnitine levels; CRC cis rs7666738 0.830 rs4699594 chr4:98980775 T/C cg05340658 chr4:99064831 C4orf37 0.6 9.41 0.46 8.57e-19 Colonoscopy-negative controls vs population controls; CRC cis rs35849525 0.776 rs7615318 chr3:49987475 C/T cg24110177 chr3:50126178 RBM5 -0.49 -5.67 -0.3 3.05e-8 Intelligence (multi-trait analysis); CRC cis rs7044106 0.708 rs991121 chr9:123370345 C/G cg09586646 chr9:123605570 PSMD5;LOC253039 0.54 8.02 0.4 1.87e-14 Hip circumference adjusted for BMI; CRC cis rs6502050 0.835 rs4247357 chr17:80166989 G/T cg13198984 chr17:80129470 CCDC57 0.45 7.97 0.4 2.6e-14 Life satisfaction; CRC cis rs12900413 0.687 rs72754547 chr15:90308166 A/C cg24249390 chr15:90295951 MESP1 -0.57 -9.13 -0.45 7.11e-18 Coronary artery aneurysm in Kawasaki disease; CRC cis rs2549003 0.966 rs2706385 chr5:131831766 T/G cg21138405 chr5:131827807 IRF1 -0.59 -11.64 -0.54 1.91e-26 Asthma (sex interaction); CRC cis rs7412746 0.658 rs1027699 chr1:150811712 T/C cg17724175 chr1:150552817 MCL1 0.48 7.18 0.37 4.82e-12 Melanoma; CRC cis rs754466 0.561 rs72806025 chr10:79707026 C/T cg17075019 chr10:79541650 NA -0.61 -6.85 -0.35 3.65e-11 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs847577 0.651 rs10464490 chr7:97715319 T/G cg21770322 chr7:97807741 LMTK2 0.84 18.44 0.71 1.18e-52 Breast cancer; CRC cis rs3008870 0.816 rs1118392 chr1:67366549 A/G cg08660285 chr1:67390436 MIER1;WDR78 -0.7 -10.06 -0.48 6.32e-21 Lymphocyte percentage of white cells; CRC cis rs995000 0.931 rs28641195 chr1:63128081 C/T cg19896129 chr1:63156450 NA -0.42 -6.45 -0.34 3.91e-10 Triglyceride levels; CRC cis rs34172651 0.917 rs2059134 chr16:24816492 C/T cg06505273 chr16:24850292 NA -0.39 -5.83 -0.31 1.32e-8 Intelligence (multi-trait analysis); CRC cis rs2239547 0.603 rs7644973 chr3:53082937 C/T cg10802521 chr3:52805072 NEK4 -0.45 -5.95 -0.31 6.69e-9 Schizophrenia; CRC cis rs3789045 0.774 rs12031912 chr1:204476113 A/G cg17419461 chr1:204415978 PIK3C2B -0.57 -7.89 -0.4 4.47e-14 Educational attainment (college completion); CRC cis rs1552244 0.935 rs11926481 chr3:10142102 G/T cg00166722 chr3:10149974 C3orf24 0.65 8.94 0.44 2.86e-17 Alzheimer's disease; CRC cis rs9322193 0.884 rs9371201 chr6:150145001 C/T cg05861140 chr6:150128134 PCMT1 -0.41 -6.25 -0.33 1.3e-9 Lung cancer; CRC cis rs754466 0.914 rs12219971 chr10:79701526 T/C cg17075019 chr10:79541650 NA -0.73 -10.27 -0.49 1.17e-21 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs1552244 1.000 rs35198334 chr3:10104553 G/C cg08888203 chr3:10149979 C3orf24 0.73 9.99 0.48 1.03e-20 Alzheimer's disease; CRC cis rs7811142 0.943 rs73403312 chr7:100024153 T/C cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.97 13.45 0.6 3.81e-33 Platelet count; CRC cis rs847577 0.506 rs7808528 chr7:97721425 G/T cg24562669 chr7:97807699 LMTK2 0.78 17.5 0.69 6.1e-49 Breast cancer; CRC cis rs35146811 0.735 rs858512 chr7:99824453 A/G cg13334819 chr7:99746414 C7orf59 0.56 7.27 0.37 2.61e-12 Coronary artery disease; CRC cis rs72781680 1.000 rs56068891 chr2:24230633 A/G cg08917208 chr2:24149416 ATAD2B 1.01 9.72 0.47 8.58e-20 Lymphocyte counts; CRC cis rs763121 0.524 rs760645 chr22:39032270 C/T cg06022373 chr22:39101656 GTPBP1 0.53 7.58 0.39 3.51e-13 Menopause (age at onset); CRC cis rs16882447 0.607 rs2783 chr5:53489874 C/T cg06461071 chr5:53490839 ARL15 -0.37 -6.08 -0.32 3.27e-9 Systolic blood pressure (dietary potassium intake interaction); CRC trans rs7944735 0.507 rs10838802 chr11:48102478 A/G cg03929089 chr4:120376271 NA 0.59 7.99 0.4 2.3e-14 Intraocular pressure; CRC cis rs780096 0.565 rs13022659 chr2:27743630 C/T cg27432699 chr2:27873401 GPN1 -0.64 -9.82 -0.48 4e-20 Total body bone mineral density; CRC trans rs2898290 0.592 rs2736342 chr8:11347289 A/C cg16141378 chr3:129829833 LOC729375 0.46 7.2 0.37 4.12e-12 Systolic blood pressure; CRC cis rs8014204 0.781 rs10143492 chr14:75212114 G/C cg03030879 chr14:75389066 RPS6KL1 -0.42 -6.68 -0.35 1.04e-10 Caffeine consumption; CRC cis rs1348850 0.793 rs13020788 chr2:178480714 C/A cg02961200 chr2:178257176 LOC100130691;AGPS 0.5 7.27 0.37 2.63e-12 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs898097 0.585 rs9893200 chr17:80893028 A/C cg03160526 chr17:80928410 B3GNTL1 0.49 8.0 0.4 2.11e-14 Breast cancer; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg13441983 chr11:10327014 ADM 0.47 6.94 0.36 2.06e-11 Response to antipsychotic treatment; CRC cis rs9837602 0.529 rs793458 chr3:99520169 C/T cg07805332 chr3:99536008 MIR548G;C3orf26 0.52 7.75 0.39 1.12e-13 Breast cancer; CRC trans rs7395662 0.892 rs11040014 chr11:48783057 G/A cg21153622 chr11:89784906 NA 0.44 7.02 0.36 1.29e-11 HDL cholesterol; CRC cis rs13161895 1.000 rs17079966 chr5:179443190 G/T cg02702477 chr5:179499311 RNF130 0.58 6.91 0.36 2.59e-11 LDL cholesterol; CRC cis rs7107174 0.901 rs11237487 chr11:78126754 G/C cg02023728 chr11:77925099 USP35 0.41 6.27 0.33 1.15e-9 Testicular germ cell tumor; CRC cis rs9291683 0.668 rs2241474 chr4:10086015 T/C cg11266682 chr4:10021025 SLC2A9 0.47 9.41 0.46 8.56e-19 Bone mineral density; CRC cis rs6740322 0.841 rs10211126 chr2:43551416 G/T cg06169590 chr2:43455088 ZFP36L2;LOC100129726 -0.61 -7.31 -0.37 2.11e-12 Coronary artery disease; CRC cis rs11250464 0.833 rs4554799 chr10:1407728 C/T cg26394196 chr10:1453818 ADARB2 -0.35 -6.21 -0.32 1.64e-9 Radiation response; CRC cis rs2294693 0.945 rs9369255 chr6:40989503 T/C cg14769373 chr6:40998127 UNC5CL -0.51 -6.59 -0.34 1.72e-10 Gastric cancer;Non-cardia gastric cancer; CRC cis rs1178968 0.818 rs4717084 chr7:72764541 C/T cg25889504 chr7:72793014 NA 0.52 5.96 0.31 6.55e-9 Triglyceride levels; CRC cis rs4925386 0.840 rs6143035 chr20:60920700 C/T cg06026331 chr20:60912101 LAMA5 -0.37 -5.67 -0.3 3.18e-8 Colorectal cancer;Colorectal cancer (SNP x SNP interaction); CRC cis rs1401999 0.659 rs7622660 chr3:183753337 C/T cg20387954 chr3:183756860 HTR3D 0.44 7.13 0.37 6.59e-12 Anterior chamber depth; CRC cis rs2404602 0.692 rs1116535 chr15:77009514 C/G cg22467129 chr15:76604101 ETFA 0.4 6.64 0.34 1.28e-10 Blood metabolite levels; CRC cis rs425277 0.583 rs10910046 chr1:2041155 C/T cg24578937 chr1:2090814 PRKCZ -0.39 -7.13 -0.37 6.23e-12 Height; CRC cis rs853679 0.517 rs9368553 chr6:28082265 T/C cg12963246 chr6:28129442 ZNF389 0.5 5.8 0.3 1.53e-8 Depression; CRC cis rs8170 1.000 rs10418154 chr19:17386006 A/G cg04749549 chr19:17459798 NA -0.43 -5.88 -0.31 1.01e-8 Breast cancer (estrogen-receptor negative);Breast Cancer in BRCA1 mutation carriers;Ovarian cancer;Breast cancer;Epithelial ovarian cancer; CRC cis rs1552244 1.000 rs4260416 chr3:10125283 C/T cg08888203 chr3:10149979 C3orf24 0.71 10.1 0.49 4.55e-21 Alzheimer's disease; CRC cis rs4253772 0.550 rs9615913 chr22:46668515 A/T cg09491104 chr22:46646882 C22orf40 0.47 7.35 0.38 1.54e-12 LDL cholesterol;Cholesterol, total; CRC cis rs968567 0.817 rs61896141 chr11:61556039 A/C cg10868875 chr11:61596307 FADS2 -0.55 -7.1 -0.36 7.97e-12 Blood metabolite levels;Rheumatoid arthritis;Vitiligo;Glycerophospholipid levels; CRC trans rs11039798 0.588 rs11039818 chr11:48562120 C/T cg15704280 chr7:45808275 SEPT13 0.64 6.88 0.35 3.07e-11 Axial length; CRC cis rs9296404 1 rs9296404 chr6:42925803 T/C cg27588902 chr6:42928151 GNMT -0.4 -7.28 -0.37 2.43e-12 Plasma homocysteine levels (post-methionine load test); CRC cis rs3820068 0.705 rs4646087 chr1:15822404 A/G cg27534772 chr1:16042836 PLEKHM2 0.41 6.95 0.36 1.99e-11 Systolic blood pressure; CRC cis rs9682041 0.825 rs6785326 chr3:170095145 T/C cg11886554 chr3:170076028 SKIL 0.84 9.04 0.45 1.41e-17 Glomerular filtration rate in non diabetics (creatinine);Glomerular filtration rate (creatinine); CRC cis rs11123170 0.503 rs28679654 chr2:113967617 C/T cg21550016 chr2:113992930 PAX8;LOC440839;LOC654433 0.52 6.25 0.33 1.24e-9 Renal function-related traits (BUN); CRC cis rs9649213 0.593 rs6969234 chr7:97987986 T/C cg21770322 chr7:97807741 LMTK2 0.52 8.47 0.42 8.07e-16 Prostate cancer (SNP x SNP interaction); CRC cis rs853679 0.657 rs1778483 chr6:28240991 T/G cg21251018 chr6:28226885 NKAPL 0.5 8.2 0.41 5.34e-15 Depression; CRC cis rs56399783 0.901 rs11764225 chr7:2775607 G/A cg19731401 chr7:2775893 GNA12 0.63 6.91 0.36 2.54e-11 Childhood ear infection; CRC cis rs6460942 0.915 rs62448596 chr7:12446869 C/T cg20607287 chr7:12443886 VWDE -0.68 -7.35 -0.38 1.59e-12 Coronary artery disease; CRC cis rs10540 1.000 rs61876342 chr11:496193 T/G cg21784768 chr11:537496 LRRC56 -0.68 -6.51 -0.34 2.8e-10 Body mass index; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg01881255 chr19:40950703 SERTAD3 0.45 6.14 0.32 2.39e-9 Anxiety disorder; CRC cis rs7937682 0.889 rs2850247 chr11:111637202 C/A cg09085632 chr11:111637200 PPP2R1B 1.1 27.56 0.84 1.78e-87 Primary sclerosing cholangitis; CRC cis rs4642101 0.662 rs3901664 chr3:12824660 T/C cg24848339 chr3:12840334 CAND2 0.31 5.82 0.31 1.42e-8 QRS complex (12-leadsum); CRC cis rs2274273 0.662 rs2147970 chr14:55660217 C/T cg10130446 chr14:55658398 DLGAP5 -0.43 -5.75 -0.3 2.08e-8 Protein biomarker; CRC cis rs34172651 0.917 rs200536 chr16:24749203 G/A cg06505273 chr16:24850292 NA -0.39 -5.7 -0.3 2.7e-8 Intelligence (multi-trait analysis); CRC trans rs10983614 1.000 rs7867776 chr9:120072627 A/G cg03506525 chr22:21213099 SNAP29;PI4KA 0.46 6.02 0.31 4.57e-9 Survival in pancreatic cancer; CRC cis rs11577318 0.853 rs2276712 chr1:26627478 T/C cg00852783 chr1:26633632 UBXN11 0.47 6.79 0.35 5.16e-11 Granulocyte percentage of myeloid white cells; CRC cis rs8141529 0.719 rs5762825 chr22:29223642 A/G cg15103426 chr22:29168792 CCDC117 0.59 8.59 0.43 3.44e-16 Lymphocyte counts; CRC trans rs804280 0.509 rs12719915 chr8:11786255 A/G cg06636001 chr8:8085503 FLJ10661 -0.43 -6.06 -0.32 3.7e-9 Myopia (pathological); CRC cis rs9640161 0.673 rs34489187 chr7:150044379 G/A cg12556325 chr7:150026731 C7orf29;LRRC61 -0.47 -6.78 -0.35 5.63e-11 Blood protein levels;Circulating chemerin levels; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg17816893 chr10:118934735 NA 0.46 6.98 0.36 1.63e-11 Intelligence (multi-trait analysis); CRC cis rs904251 1.000 rs10947673 chr6:37445079 C/T cg25019722 chr6:37503610 NA -0.37 -6.53 -0.34 2.57e-10 Cognitive performance; CRC cis rs4423214 0.570 rs7118246 chr11:71231124 G/C cg05163923 chr11:71159392 DHCR7 0.57 7.23 0.37 3.49e-12 Vitamin D levels; CRC trans rs2303319 0.504 rs56371522 chr2:162491109 G/A cg25193742 chr10:104614220 C10orf32 -0.72 -5.97 -0.31 6.32e-9 Cognitive function; CRC cis rs2404602 0.647 rs12440965 chr15:76958591 G/A cg23625390 chr15:77176239 SCAPER -0.85 -13.31 -0.59 1.28e-32 Blood metabolite levels; CRC trans rs7618501 1.000 rs3749240 chr3:49750188 T/A cg21659725 chr3:3221576 CRBN -0.9 -17.41 -0.69 1.45e-48 Intelligence (multi-trait analysis); CRC cis rs1448094 0.872 rs7300073 chr12:86393513 A/C cg02569458 chr12:86230093 RASSF9 0.4 6.69 0.35 9.82e-11 Major depressive disorder; CRC cis rs7589728 0.563 rs4972044 chr2:88466196 T/C cg24977027 chr2:88469347 THNSL2 0.63 7.75 0.39 1.14e-13 Plasma clusterin levels; CRC cis rs6860806 0.507 rs270608 chr5:131648406 C/T cg07395648 chr5:131743802 NA -0.43 -5.76 -0.3 1.91e-8 Breast cancer; CRC cis rs561341 0.830 rs7218801 chr17:30217778 A/G cg13647721 chr17:30228624 UTP6 -0.57 -5.88 -0.31 9.94e-9 Hip circumference adjusted for BMI; CRC cis rs2227564 0.620 rs12783161 chr10:75572201 G/C cg00564723 chr10:75632066 CAMK2G -0.31 -7.47 -0.38 7.11e-13 Crohn's disease;Inflammatory bowel disease; CRC cis rs8180040 0.966 rs13075233 chr3:47420627 T/C cg27129171 chr3:47204927 SETD2 0.52 8.11 0.41 1.03e-14 Colorectal cancer; CRC cis rs3820068 0.581 rs6692461 chr1:15928449 A/G cg27534772 chr1:16042836 PLEKHM2 0.55 10.92 0.52 6.82e-24 Systolic blood pressure; CRC cis rs798554 0.757 rs1182178 chr7:2873763 G/A cg13628971 chr7:2884303 GNA12 0.52 6.99 0.36 1.49e-11 Height; CRC cis rs2732480 0.577 rs2732448 chr12:48730600 T/C cg21466736 chr12:48725269 NA -0.62 -9.33 -0.46 1.56e-18 Hemoglobin concentration;Red blood cell count;Hematocrit; CRC cis rs17095355 1.000 rs59804002 chr10:111692043 G/T cg00817464 chr10:111662876 XPNPEP1 -0.57 -6.85 -0.35 3.55e-11 Biliary atresia; CRC cis rs12760731 0.565 rs78577576 chr1:178141982 A/G cg00404053 chr1:178313656 RASAL2 1.02 10.73 0.51 3.15e-23 Obesity-related traits; CRC cis rs6879260 1.000 rs729568 chr5:179732350 C/T cg23221052 chr5:179740743 GFPT2 0.63 9.72 0.47 8.63e-20 Height; CRC cis rs1904096 0.506 rs2865350 chr4:95212813 A/T cg11021082 chr4:95130006 SMARCAD1 0.48 6.93 0.36 2.22e-11 Type 2 diabetes; CRC cis rs4689388 0.889 rs10026334 chr4:6294607 G/A cg14416269 chr4:6271139 WFS1 0.4 6.59 0.34 1.72e-10 Type 2 diabetes and other traits;Type 2 diabetes; CRC cis rs4700695 1.000 rs3846481 chr5:65417803 T/C cg21114390 chr5:65439923 SFRS12 -0.61 -6.88 -0.35 3.02e-11 Facial morphology (factor 19); CRC cis rs6546550 0.935 rs6546551 chr2:70073703 C/T cg02498382 chr2:70120550 SNRNP27 -0.48 -7.8 -0.4 8.33e-14 Prevalent atrial fibrillation; CRC cis rs2204008 0.811 rs11525004 chr12:38333807 T/A cg13010199 chr12:38710504 ALG10B 0.46 6.08 0.32 3.31e-9 Bladder cancer; CRC cis rs12200560 0.505 rs211162 chr6:97067344 G/A cg06623918 chr6:96969491 KIAA0776 0.47 6.77 0.35 5.9e-11 Coronary heart disease; CRC cis rs9611565 0.729 rs73176689 chr22:41782633 T/C cg03806693 chr22:41940476 POLR3H -1.07 -13.38 -0.59 6.74e-33 Vitiligo; CRC cis rs12760731 0.920 rs3813637 chr1:178491680 C/G cg00404053 chr1:178313656 RASAL2 0.72 7.88 0.4 4.93e-14 Obesity-related traits; CRC cis rs6743376 0.556 rs2251876 chr2:113818727 A/G cg09040174 chr2:113837401 NA 0.38 5.72 0.3 2.36e-8 Inflammatory biomarkers; CRC cis rs6694672 0.867 rs1764629 chr1:197216632 A/G cg13682187 chr1:196946512 CFHR5 0.49 6.92 0.36 2.31e-11 Asthma; CRC cis rs9303280 0.806 rs13380815 chr17:38027583 A/G cg11212589 chr17:38028394 ZPBP2 0.43 7.93 0.4 3.34e-14 Self-reported allergy; CRC cis rs1475911 1.000 rs2839467 chr21:43513200 A/G cg24372256 chr21:43528868 UMODL1;C21orf128 0.54 7.24 0.37 3.14e-12 IgG glycosylation; CRC cis rs8078723 0.714 rs12940405 chr17:38143768 C/T cg17467752 chr17:38218738 THRA -0.57 -9.05 -0.45 1.27e-17 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); CRC trans rs6952808 0.582 rs10479762 chr7:2045351 T/C cg04565464 chr8:145669602 NFKBIL2 -0.43 -6.61 -0.34 1.58e-10 Bipolar disorder and schizophrenia; CRC cis rs1552244 1.000 rs56394721 chr3:10150795 A/G cg13047869 chr3:10149882 C3orf24 0.58 7.74 0.39 1.25e-13 Alzheimer's disease; CRC cis rs6952808 0.531 rs3778991 chr7:2172455 G/A cg21782813 chr7:2030301 MAD1L1 0.51 8.67 0.43 1.98e-16 Bipolar disorder and schizophrenia; CRC cis rs9549328 0.765 rs1317506 chr13:113631143 C/T cg08614441 chr13:113633676 MCF2L -0.44 -7.92 -0.4 3.63e-14 Systolic blood pressure; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg06380449 chr17:73255012 GGA3 0.4 6.13 0.32 2.51e-9 Liver disease severity in Alagille syndrome; CRC cis rs916888 0.821 rs70600 chr17:44860021 C/T cg17911788 chr17:44343683 NA -0.6 -7.2 -0.37 4.21e-12 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs4481887 0.927 rs28524655 chr1:248474331 C/T cg13385794 chr1:248469461 NA 0.38 6.75 0.35 6.84e-11 Common traits (Other); CRC cis rs921968 0.643 rs524012 chr2:219433273 T/G cg02176678 chr2:219576539 TTLL4 0.47 7.86 0.4 5.36e-14 Mean corpuscular hemoglobin concentration; CRC cis rs7618501 1.000 rs7618519 chr3:49772708 A/T cg24308560 chr3:49941425 MST1R 0.45 7.01 0.36 1.32e-11 Intelligence (multi-trait analysis); CRC cis rs9393692 0.905 rs9393694 chr6:26279296 T/C cg00631329 chr6:26305371 NA -0.68 -13.44 -0.6 3.92e-33 Educational attainment; CRC cis rs4481887 0.927 rs4603165 chr1:248473799 T/A cg00666640 chr1:248458726 OR2T12 0.48 8.14 0.41 7.98e-15 Common traits (Other); CRC cis rs919433 0.680 rs7605813 chr2:198375329 C/G cg10820045 chr2:198174542 NA 0.39 6.37 0.33 6.39e-10 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC cis rs7107174 1.000 rs10899457 chr11:78001163 T/A cg02023728 chr11:77925099 USP35 0.53 7.5 0.38 5.91e-13 Testicular germ cell tumor; CRC cis rs1799949 0.896 rs33933393 chr17:41317432 C/T cg19454999 chr17:41278357 BRCA1;NBR2 0.55 8.68 0.43 1.89e-16 Menopause (age at onset); CRC cis rs6714710 0.603 rs17489454 chr2:98407350 C/T cg26665480 chr2:98280029 ACTR1B 0.51 7.08 0.36 8.58e-12 Posterior cortical atrophy and Alzheimer's disease; CRC cis rs6502050 0.799 rs6416859 chr17:80111442 G/C cg11859384 chr17:80120422 CCDC57 -0.37 -5.85 -0.31 1.16e-8 Life satisfaction; CRC cis rs6951245 0.572 rs80133931 chr7:1027286 C/T cg21664854 chr7:1097933 C7orf50;GPR146 0.77 5.9 0.31 9.17e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs9814567 1.000 rs9854299 chr3:134206728 T/C cg06541857 chr3:134203789 ANAPC13;CEP63 -0.41 -6.21 -0.32 1.63e-9 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs6988985 0.728 rs4310186 chr8:143956247 C/G cg10324643 chr8:143916377 GML -0.36 -6.03 -0.32 4.44e-9 Plasma androstenedione levels in resected early stage-receptor positive breast cancer; CRC cis rs57590327 0.503 rs13075250 chr3:81907952 T/C cg07356753 chr3:81810745 GBE1 -0.57 -7.69 -0.39 1.76e-13 Extraversion; CRC cis rs2576037 0.583 rs646128 chr18:44397691 A/C cg23996704 chr18:44553084 KATNAL2 -0.31 -6.05 -0.32 4e-9 Personality dimensions; CRC cis rs860295 0.812 rs7556519 chr1:155827546 T/C cg02153340 chr1:155202674 NA -0.5 -6.25 -0.33 1.27e-9 Body mass index; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg06377929 chr1:1407001 ATAD3B -0.41 -6.07 -0.32 3.6e-9 Myopia (pathological); CRC cis rs9640161 0.750 rs11764936 chr7:150025915 G/T cg12556325 chr7:150026731 C7orf29;LRRC61 -0.45 -6.9 -0.36 2.67e-11 Blood protein levels;Circulating chemerin levels; CRC trans rs10242455 0.702 rs28460612 chr7:98993205 C/G cg09045935 chr12:6379348 NA 0.99 7.45 0.38 8.27e-13 Blood metabolite levels; CRC cis rs4728142 0.593 rs7808907 chr7:128584084 C/T cg06630958 chr7:128577819 IRF5 0.35 5.99 0.31 5.38e-9 Inflammatory bowel disease;Systemic lupus erythematosus;Ulcerative colitis; CRC cis rs6502050 0.805 rs62078303 chr17:80085210 A/G cg22110888 chr17:80059540 CCDC57 -0.41 -6.39 -0.33 5.58e-10 Life satisfaction; CRC cis rs4713118 0.955 rs9468200 chr6:27683063 T/A cg15845792 chr6:28175446 NA 0.59 7.63 0.39 2.61e-13 Parkinson's disease; CRC cis rs904251 0.861 rs2776875 chr6:37486796 G/C cg01843034 chr6:37503916 NA -0.48 -8.89 -0.44 4.24e-17 Cognitive performance; CRC cis rs7508679 1.000 rs10410204 chr19:7224350 C/T cg09779027 chr19:7224513 INSR 1.04 23.48 0.79 2.77e-72 Hypothyroidism; CRC cis rs736801 0.808 rs6866614 chr5:131787137 A/G cg21138405 chr5:131827807 IRF1 0.37 6.23 0.32 1.42e-9 Breast cancer;Mosquito bite size; CRC trans rs6550704 0.687 rs9865314 chr3:22634337 A/G cg01524359 chr1:46049306 NASP -0.43 -6.24 -0.33 1.38e-9 Daytime sleep phenotypes; CRC cis rs1799949 0.965 rs11650913 chr17:41331597 T/C cg19454999 chr17:41278357 BRCA1;NBR2 0.53 8.28 0.42 3.22e-15 Menopause (age at onset); CRC cis rs2976388 0.609 rs1594999 chr8:143790574 G/A cg04969067 chr8:143858791 LYNX1 0.45 7.59 0.39 3.26e-13 Urinary tract infection frequency; CRC cis rs1862618 0.853 rs832551 chr5:56180112 T/G cg18230493 chr5:56204884 C5orf35 -0.75 -9.27 -0.45 2.61e-18 Initial pursuit acceleration; CRC cis rs3825932 0.961 rs10400877 chr15:79234378 A/T cg25744700 chr15:79237217 CTSH 0.4 6.17 0.32 2.02e-9 Type 1 diabetes; CRC cis rs7399018 0.739 rs10747608 chr12:51616582 A/G cg20712883 chr12:51590929 POU6F1 0.46 6.29 0.33 1.02e-9 Cisplatin-induced ototoxicity; CRC cis rs904251 0.772 rs1812186 chr6:37465916 T/C cg25019722 chr6:37503610 NA -0.41 -6.72 -0.35 8.03e-11 Cognitive performance; CRC cis rs10504229 1.000 rs66870803 chr8:58180022 G/C cg02725872 chr8:58115012 NA -0.38 -6.43 -0.33 4.44e-10 Developmental language disorder (linguistic errors); CRC cis rs6951245 0.938 rs78351779 chr7:1097023 G/C cg07217954 chr7:1067459 C7orf50 0.55 5.72 0.3 2.36e-8 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs9463078 0.764 rs976699 chr6:44952852 G/T cg25276700 chr6:44698697 NA -0.28 -6.91 -0.36 2.59e-11 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; CRC cis rs8060686 0.565 rs75735284 chr16:68126635 C/A cg08314208 chr16:67682810 RLTPR -0.58 -6.22 -0.32 1.53e-9 HDL cholesterol;Metabolic syndrome; CRC cis rs9467711 0.606 rs34273322 chr6:26415409 T/A cg12315302 chr6:26189340 HIST1H4D 0.77 5.99 0.31 5.51e-9 Autism spectrum disorder or schizophrenia; CRC cis rs9322193 0.809 rs9479808 chr6:150072464 A/T cg07701084 chr6:150067640 NUP43 0.6 8.84 0.44 5.92e-17 Lung cancer; CRC cis rs208520 0.690 rs851467 chr6:66802721 A/G cg07460842 chr6:66804631 NA -1.08 -15.25 -0.64 4.51e-40 Exhaled nitric oxide output; CRC cis rs4689388 0.926 rs4234730 chr4:6296343 A/G cg25554036 chr4:6271136 WFS1 0.53 8.34 0.42 2.06e-15 Type 2 diabetes and other traits;Type 2 diabetes; CRC cis rs1005277 0.505 rs7917943 chr10:38195811 T/A cg25517755 chr10:38738941 LOC399744 0.45 6.57 0.34 1.93e-10 Extrinsic epigenetic age acceleration; CRC cis rs4780401 0.933 rs4584833 chr16:11798758 C/T cg01061890 chr16:11836724 TXNDC11 -0.43 -5.98 -0.31 5.87e-9 Rheumatoid arthritis; CRC cis rs644799 1.000 rs1944074 chr11:95511445 C/A cg25478527 chr11:95522999 CEP57;FAM76B 0.53 7.88 0.4 4.93e-14 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs7772486 0.875 rs2777477 chr6:146305491 A/G cg23711669 chr6:146136114 FBXO30 0.61 10.07 0.49 5.59e-21 Lobe attachment (rater-scored or self-reported); CRC cis rs992157 0.710 rs6719789 chr2:219057810 G/T cg04731861 chr2:219085781 ARPC2 0.32 6.88 0.35 3.03e-11 Colorectal cancer; CRC cis rs1451375 0.698 rs1813214 chr7:50637525 A/G cg18232548 chr7:50535776 DDC 0.44 6.25 0.33 1.24e-9 Malaria; CRC cis rs6740322 0.895 rs6738717 chr2:43573670 C/T cg06169590 chr2:43455088 ZFP36L2;LOC100129726 -0.64 -7.77 -0.39 1.03e-13 Coronary artery disease; CRC cis rs9372498 0.536 rs72969531 chr6:118729974 C/A cg24463073 chr6:118973353 C6orf204 0.5 6.69 0.35 9.8e-11 Diastolic blood pressure; CRC cis rs11190604 0.945 rs11190553 chr10:102207959 T/C cg07570687 chr10:102243282 WNT8B 0.44 5.64 0.3 3.61e-8 Palmitoleic acid (16:1n-7) levels; CRC cis rs78456975 1.000 rs78456975 chr2:1554190 T/G cg01028140 chr2:1542097 TPO -0.56 -5.73 -0.3 2.25e-8 Placebo response in major depressive disorder (% change in symptom score); CRC cis rs7589728 0.563 rs75606549 chr2:88466069 T/C cg18490616 chr2:88469792 THNSL2 0.58 5.85 0.31 1.22e-8 Plasma clusterin levels; CRC cis rs10791323 0.628 rs2853117 chr11:133705266 T/G cg00579200 chr11:133705235 NA -0.41 -5.96 -0.31 6.32e-9 Childhood ear infection; CRC cis rs12928939 0.911 rs11645704 chr16:71826611 G/T cg08717414 chr16:71523259 ZNF19 -0.51 -6.35 -0.33 7.13e-10 Post bronchodilator FEV1; CRC cis rs3785574 0.962 rs8066463 chr17:61818390 A/G cg06873352 chr17:61820015 STRADA 0.49 7.95 0.4 3.06e-14 Height; CRC cis rs2303745 0.544 rs6512181 chr19:17399213 T/G cg15110403 chr19:17392923 ANKLE1 -0.36 -5.75 -0.3 1.99e-8 Systemic lupus erythematosus; CRC cis rs651907 0.535 rs61396602 chr3:101509046 T/C cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.59 7.8 0.4 8.2e-14 Colorectal cancer; CRC cis rs6496667 0.779 rs10083679 chr15:91022139 A/G cg04176472 chr15:90893244 GABARAPL3 0.51 7.33 0.37 1.77e-12 Rheumatoid arthritis; CRC cis rs35110281 0.667 rs4819288 chr21:45120173 C/G cg04455712 chr21:45112962 RRP1B 0.4 7.61 0.39 2.9e-13 Mean corpuscular volume; CRC cis rs35110281 0.807 rs2838326 chr21:45014315 C/T cg01579765 chr21:45077557 HSF2BP -0.34 -6.4 -0.33 5.3e-10 Mean corpuscular volume; CRC cis rs6456156 0.586 rs12528689 chr6:167461746 A/G cg07741184 chr6:167504864 NA 0.39 6.9 0.36 2.63e-11 Primary biliary cholangitis; CRC cis rs629535 0.748 rs58675625 chr8:70034924 T/C cg26132723 chr8:70041827 NA 0.35 5.72 0.3 2.41e-8 Dupuytren's disease; CRC cis rs763014 1.000 rs2269558 chr16:682250 C/T cg08989290 chr16:615782 NHLRC4 0.48 9.2 0.45 4.14e-18 Height; CRC cis rs4730250 0.655 rs75243311 chr7:106890791 C/T cg02696742 chr7:106810147 HBP1 -0.5 -5.65 -0.3 3.4e-8 Osteoarthritis; CRC cis rs748404 0.660 rs518288 chr15:43763999 C/T cg02155558 chr15:43621948 ADAL;LCMT2 0.53 7.69 0.39 1.71e-13 Lung cancer; CRC cis rs2732480 0.557 rs2732454 chr12:48719677 T/C cg04545296 chr12:48745243 ZNF641 0.33 5.68 0.3 3e-8 Hemoglobin concentration;Red blood cell count;Hematocrit; CRC cis rs11229555 0.645 rs12269928 chr11:58184358 T/C cg15696309 chr11:58395628 NA -0.81 -10.31 -0.49 8.83e-22 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; CRC cis rs6424115 0.867 rs11588187 chr1:24145047 T/A cg09473613 chr1:24152604 HMGCL 0.34 5.92 0.31 8.21e-9 Immature fraction of reticulocytes; CRC cis rs8177253 0.965 rs7638018 chr3:133495461 C/T cg01448562 chr3:133502909 NA 0.52 8.89 0.44 4.15e-17 Iron status biomarkers; CRC cis rs453301 0.686 rs28665409 chr8:8869277 G/A cg14979609 chr8:8086686 FLJ10661 0.36 5.77 0.3 1.81e-8 Joint mobility (Beighton score); CRC cis rs7777754 0.512 rs11238131 chr7:50538589 T/C cg18232548 chr7:50535776 DDC -0.46 -6.98 -0.36 1.67e-11 Response to zileuton treatment in asthma (FEV1 change interaction); CRC cis rs13256369 0.755 rs12550057 chr8:8562268 G/A cg18904891 chr8:8559673 CLDN23 0.54 7.14 0.37 5.99e-12 Obesity-related traits; CRC cis rs9372498 0.536 rs55899435 chr6:118812099 C/T cg24463073 chr6:118973353 C6orf204 0.52 6.9 0.36 2.6e-11 Diastolic blood pressure; CRC cis rs9462846 1.000 rs9471942 chr6:42861532 C/T cg02353165 chr6:42928485 GNMT 0.54 6.91 0.36 2.57e-11 Blood protein levels; CRC cis rs6460942 0.731 rs75994414 chr7:12307992 C/A cg20607287 chr7:12443886 VWDE -0.6 -6.22 -0.32 1.55e-9 Coronary artery disease; CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg10387458 chr1:93645817 TMED5;CCDC18 0.42 6.83 0.35 4.11e-11 Obesity-related traits; CRC cis rs992157 0.710 rs7569907 chr2:219070551 C/T cg04731861 chr2:219085781 ARPC2 -0.32 -6.85 -0.35 3.73e-11 Colorectal cancer; CRC cis rs1572438 0.868 rs1577625 chr6:860044 C/A cg13447295 chr6:887704 NA -0.44 -6.67 -0.35 1.06e-10 Aging; CRC cis rs501120 0.640 rs10900001 chr10:44695585 C/G cg09554077 chr10:44749378 NA 0.67 7.47 0.38 7.24e-13 Coronary artery disease;Coronary heart disease; CRC cis rs425277 0.606 rs16824792 chr1:2039521 G/T cg19257562 chr1:2043853 PRKCZ 0.39 6.53 0.34 2.5e-10 Height; CRC cis rs2404602 0.735 rs11629888 chr15:76719880 A/T cg23625390 chr15:77176239 SCAPER -0.82 -12.09 -0.55 4.28e-28 Blood metabolite levels; CRC cis rs7147624 0.608 rs4902413 chr14:66187091 T/C cg03016385 chr14:66212404 NA -1.05 -10.69 -0.51 4.34e-23 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs11711311 1.000 rs2603793 chr3:113496418 A/C cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.52 -7.14 -0.37 6.11e-12 IgG glycosylation; CRC cis rs755249 0.567 rs2296172 chr1:39835817 A/G cg18385671 chr1:39797026 MACF1 -0.4 -5.78 -0.3 1.74e-8 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs6952808 0.656 rs11764212 chr7:2067593 C/A cg04267008 chr7:1944627 MAD1L1 -0.79 -11.12 -0.52 1.39e-24 Bipolar disorder and schizophrenia; CRC cis rs2760061 0.819 rs3094913 chr1:228206980 T/C cg02753203 chr1:228287806 NA 0.71 10.94 0.52 5.75e-24 Diastolic blood pressure; CRC cis rs2012796 1.000 rs7153469 chr14:81820979 T/G cg02996355 chr14:81879375 NA 0.55 8.1 0.41 1.12e-14 Night sleep phenotypes; CRC trans rs9467711 0.559 rs6920256 chr6:26537801 G/A cg06606381 chr12:133084897 FBRSL1 -0.76 -6.09 -0.32 3.19e-9 Autism spectrum disorder or schizophrenia; CRC trans rs6561151 0.957 rs1932990 chr13:44460242 C/T cg12856521 chr11:46389249 DGKZ 0.6 8.78 0.44 9.08e-17 Crohn's disease; CRC cis rs4713118 0.662 rs149900 chr6:28014597 C/T cg15786705 chr6:28176104 NA 0.66 8.93 0.44 3.1e-17 Parkinson's disease; CRC cis rs7584330 0.740 rs13418586 chr2:238445593 A/G cg16989719 chr2:238392110 NA -0.4 -8.25 -0.41 3.95e-15 Prostate cancer; CRC cis rs2712184 0.935 rs2541387 chr2:217666174 A/C cg05032264 chr2:217675019 NA -0.33 -5.62 -0.3 4.15e-8 Glomerular filtration rate;Glomerular filtration rate in non diabetics (creatinine); CRC cis rs2439831 0.850 rs28513374 chr15:44125495 G/A cg02155558 chr15:43621948 ADAL;LCMT2 0.69 7.46 0.38 7.65e-13 Lung cancer in ever smokers; CRC cis rs55871839 0.708 rs12114218 chr8:59817454 T/C cg07426533 chr8:59803705 TOX -0.35 -6.07 -0.32 3.62e-9 Pneumonia; CRC cis rs524023 1.000 rs537246 chr11:64360630 G/A cg06522879 chr11:64358276 SLC22A12 0.57 8.85 0.44 5.42e-17 Urate levels in obese individuals; CRC cis rs4713118 0.662 rs149961 chr6:28015569 A/C cg12273811 chr6:28175739 NA 0.61 8.25 0.41 3.99e-15 Parkinson's disease; CRC trans rs12432203 1.000 rs72622440 chr14:51737191 C/T cg14592830 chr9:122318704 NA 0.58 6.0 0.31 5.07e-9 Cancer; CRC cis rs2251381 0.520 rs873651 chr21:30781848 G/A cg08807101 chr21:30365312 RNF160 0.58 8.36 0.42 1.84e-15 Selective IgA deficiency; CRC cis rs4481887 1.000 rs7513161 chr1:248453422 A/T cg00666640 chr1:248458726 OR2T12 0.53 9.43 0.46 7.58e-19 Common traits (Other); CRC cis rs6142102 0.961 rs2268089 chr20:32667298 T/C cg08999081 chr20:33150536 PIGU 0.38 5.92 0.31 8.21e-9 Skin pigmentation; CRC cis rs9990333 0.622 rs57783901 chr3:195816357 G/A cg12923728 chr3:195709715 SDHAP1 -0.44 -5.97 -0.31 6.3e-9 Iron status biomarkers (transferrin levels);Iron status biomarkers (transferrin saturation); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg12349875 chr7:32530336 LSM5 0.42 6.1 0.32 2.95e-9 Response to antipsychotic treatment; CRC trans rs10982213 0.830 rs2274163 chr9:117188714 C/T cg25940730 chr4:16228647 TAPT1;FLJ39653 0.4 6.18 0.32 1.87e-9 Interleukin-6 levels; CRC trans rs7726839 1.000 rs7726839 chr5:618586 A/G cg25482853 chr8:67687455 SGK3 0.65 8.5 0.42 6.61e-16 Obesity-related traits; CRC cis rs2066819 1.000 rs11575231 chr12:56744445 T/C cg26714650 chr12:56694279 CS -1.44 -11.18 -0.52 8.02e-25 Psoriasis vulgaris; CRC trans rs2303319 0.504 rs62189052 chr2:162623869 C/G cg14875682 chr5:52083620 ITGA1;PELO -0.73 -6.12 -0.32 2.59e-9 Cognitive function; CRC cis rs76533333 0.646 rs71446625 chr13:113390285 G/T cg04656015 chr13:113407548 ATP11A 0.75 5.75 0.3 2.09e-8 Red cell distribution width; CRC cis rs8072100 0.967 rs4580230 chr17:45738861 G/A cg25173405 chr17:45401733 C17orf57 -0.47 -7.41 -0.38 1.04e-12 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs2032447 0.714 rs175319 chr6:25956172 A/G cg12588279 chr6:26043732 HIST1H2BB 0.43 6.05 0.32 4.02e-9 Intelligence (multi-trait analysis); CRC cis rs897984 0.721 rs28360557 chr16:30983260 A/C cg02466173 chr16:30829666 NA 0.62 9.32 0.46 1.78e-18 Dementia with Lewy bodies; CRC trans rs8123881 0.733 rs7268466 chr20:15810676 C/T cg04816434 chr15:22945077 CYFIP1 -0.53 -6.1 -0.32 2.94e-9 Body mass index; CRC cis rs8060686 0.641 rs76984161 chr16:68139423 C/A cg26727032 chr16:67993705 SLC12A4 -0.55 -6.3 -0.33 9.82e-10 HDL cholesterol;Metabolic syndrome; CRC cis rs11690935 0.632 rs17581284 chr2:172659376 C/T cg13550731 chr2:172543902 DYNC1I2 0.68 9.91 0.48 1.96e-20 Schizophrenia; CRC trans rs7267979 1.000 rs2387880 chr20:25377787 T/C cg17903999 chr18:56338584 MALT1 0.42 6.98 0.36 1.65e-11 Liver enzyme levels (alkaline phosphatase); CRC trans rs8073060 0.586 rs117573546 chr17:33909588 G/A cg19694781 chr19:47549865 TMEM160 1.04 14.41 0.62 7.52e-37 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; CRC cis rs7945705 0.837 rs2742474 chr11:9002089 A/G cg00186954 chr11:8933980 ST5;C11orf17 -0.4 -6.5 -0.34 2.93e-10 Hemoglobin concentration; CRC cis rs10504229 0.775 rs17805146 chr8:58161484 G/A cg11062466 chr8:58055876 NA 0.45 5.81 0.31 1.46e-8 Developmental language disorder (linguistic errors); CRC cis rs798554 0.836 rs798500 chr7:2790685 C/T cg13628971 chr7:2884303 GNA12 -0.49 -6.68 -0.35 1.05e-10 Height; CRC cis rs11148252 0.508 rs11148260 chr13:53162643 A/C cg20354231 chr13:53171401 NA -0.52 -8.71 -0.43 1.45e-16 Lewy body disease; CRC cis rs524023 0.629 rs480617 chr11:64478320 C/T cg06522879 chr11:64358276 SLC22A12 -0.43 -6.33 -0.33 8.07e-10 Urate levels in obese individuals; CRC cis rs7618915 0.501 rs3755798 chr3:52741160 G/A cg15147215 chr3:52552868 STAB1 -0.61 -10.31 -0.49 8.95e-22 Bipolar disorder; CRC cis rs3996993 0.597 rs62412888 chr6:52702026 G/A cg20803780 chr6:52668592 GSTA1 0.4 6.85 0.35 3.63e-11 Hemoglobin concentration; CRC cis rs4743820 0.651 rs73494920 chr9:93923153 G/C cg14446406 chr9:93919335 NA 0.81 14.88 0.63 1.24e-38 Ulcerative colitis;Inflammatory bowel disease; CRC trans rs747782 0.639 rs17198985 chr11:48183565 T/C cg15704280 chr7:45808275 SEPT13 0.67 6.45 0.34 3.91e-10 Intraocular pressure; CRC cis rs9372498 0.536 rs72952733 chr6:118834452 A/G cg01339444 chr6:118972232 C6orf204 0.53 5.93 0.31 7.73e-9 Diastolic blood pressure; CRC cis rs7274811 0.744 rs6141962 chr20:32110312 T/C cg03904042 chr20:32255491 NECAB3;C20orf134 -0.46 -6.48 -0.34 3.25e-10 Height; CRC trans rs853679 0.769 rs7752608 chr6:28301195 A/G cg01620082 chr3:125678407 NA -0.76 -7.0 -0.36 1.4e-11 Depression; CRC cis rs2742417 1.000 rs2673051 chr3:45732409 G/T cg04837898 chr3:45731254 SACM1L -0.35 -5.78 -0.3 1.69e-8 Response to anti-depressant treatment in major depressive disorder; CRC cis rs6681460 1.000 rs7521123 chr1:67121663 T/C cg02459107 chr1:67143332 SGIP1 0.48 8.38 0.42 1.54e-15 Presence of antiphospholipid antibodies; CRC cis rs6570726 0.764 rs9403731 chr6:145907937 G/A cg23711669 chr6:146136114 FBXO30 0.68 11.23 0.53 5.25e-25 Lobe attachment (rater-scored or self-reported); CRC cis rs6570726 0.791 rs952406 chr6:145925616 C/A cg23711669 chr6:146136114 FBXO30 0.68 11.48 0.53 7.22e-26 Lobe attachment (rater-scored or self-reported); CRC trans rs587242 1.000 rs61786492 chr1:96904739 A/C cg10631902 chr5:14652156 NA 0.44 6.84 0.35 3.84e-11 Body mass index (joint analysis main effects and physical activity interaction);Body mass index in physically inactive individuals;Body mass index; CRC cis rs7772486 0.790 rs9403756 chr6:146257761 C/G cg23711669 chr6:146136114 FBXO30 -0.67 -11.61 -0.54 2.29e-26 Lobe attachment (rater-scored or self-reported); CRC cis rs10463316 0.894 rs6891252 chr5:150762807 G/T cg03212797 chr5:150827313 SLC36A1 -0.54 -8.37 -0.42 1.64e-15 Metabolite levels (Pyroglutamine); CRC cis rs7584330 0.666 rs7600317 chr2:238353513 C/T cg14458575 chr2:238380390 NA 0.77 14.02 0.61 2.45e-35 Prostate cancer; CRC cis rs3096299 0.719 rs2911265 chr16:89511328 G/A cg01788221 chr16:89496183 ANKRD11 -0.44 -6.56 -0.34 2.12e-10 Multiple myeloma (IgH translocation); CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg17182302 chr1:116961525 C1orf203 0.36 6.04 0.32 4.16e-9 Obesity-related traits; CRC cis rs10504229 0.861 rs59873610 chr8:58172290 T/A cg22535103 chr8:58192502 C8orf71 -0.81 -12.24 -0.56 1.19e-28 Developmental language disorder (linguistic errors); CRC cis rs8072100 0.676 rs7221345 chr17:45405144 G/A cg25173405 chr17:45401733 C17orf57 -0.6 -10.29 -0.49 9.89e-22 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC trans rs4332037 0.851 rs34040190 chr7:1920356 G/A cg11693508 chr17:37793320 STARD3 0.72 8.49 0.42 7.22e-16 Bipolar disorder; CRC cis rs2404602 0.709 rs11072591 chr15:76649562 A/G cg03037974 chr15:76606532 NA 0.49 7.38 0.38 1.34e-12 Blood metabolite levels; CRC cis rs35000415 0.938 rs10488631 chr7:128594183 T/C cg19972273 chr7:128594194 NA 0.66 5.99 0.31 5.62e-9 Systemic lupus erythematosus; CRC cis rs1448094 0.813 rs6539942 chr12:86452969 T/C cg02569458 chr12:86230093 RASSF9 -0.4 -6.82 -0.35 4.48e-11 Major depressive disorder; CRC cis rs1799949 1.000 rs11656097 chr17:41290613 G/T cg19454999 chr17:41278357 BRCA1;NBR2 0.55 8.65 0.43 2.28e-16 Menopause (age at onset); CRC trans rs9858542 0.953 rs9827021 chr3:49514764 C/A cg21665057 chr3:196295764 WDR53;FBXO45 -0.66 -9.1 -0.45 8.6e-18 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs9522267 0.535 rs4773392 chr13:112227358 A/G cg26182253 chr13:112236782 NA -0.3 -6.13 -0.32 2.46e-9 Hepatitis; CRC cis rs6540559 0.673 rs17015218 chr1:209967915 A/G cg21951975 chr1:209979733 IRF6 0.49 6.58 0.34 1.85e-10 Cleft lip with or without cleft palate; CRC cis rs12545109 0.800 rs1996106 chr8:57412963 A/G cg09654669 chr8:57350985 NA -0.46 -7.45 -0.38 8.25e-13 Obesity-related traits; CRC cis rs3845702 0.866 rs818659 chr2:180870893 G/A cg23417306 chr2:180868811 CWC22 0.49 6.78 0.35 5.51e-11 Schizophrenia; CRC cis rs35520189 0.625 rs12614316 chr2:113705403 T/C cg12858261 chr2:113808755 IL1F8 0.49 6.82 0.35 4.41e-11 Obstructive sleep apnea trait (apnea hypopnea index); CRC cis rs11608355 0.545 rs11613021 chr12:109897998 T/G cg05360138 chr12:110035743 NA 0.77 8.7 0.43 1.65e-16 Neuroticism; CRC cis rs6693567 0.565 rs471657 chr1:150276461 G/A cg15654264 chr1:150340011 RPRD2 -0.4 -5.93 -0.31 7.47e-9 Migraine; CRC cis rs394563 0.690 rs237009 chr6:149759552 C/T cg16235748 chr6:149772707 ZC3H12D -0.38 -6.76 -0.35 6.21e-11 Dupuytren's disease; CRC cis rs6582630 0.519 rs11514372 chr12:38308613 T/G cg26384229 chr12:38710491 ALG10B 0.69 9.74 0.47 7.49e-20 Drug-induced liver injury (flucloxacillin); CRC trans rs9291683 0.595 rs10939665 chr4:10037628 T/C cg26043149 chr18:55253948 FECH 0.53 8.17 0.41 6.79e-15 Bone mineral density; CRC cis rs853679 0.517 rs9295758 chr6:28120663 C/G cg15786705 chr6:28176104 NA 0.78 9.83 0.48 3.57e-20 Depression; CRC cis rs2303745 0.589 rs8103523 chr19:17398269 A/G cg02221750 chr19:17393354 ANKLE1 -0.45 -6.7 -0.35 9.29e-11 Systemic lupus erythematosus; CRC trans rs11673344 0.528 rs573294 chr19:37410162 C/T cg18947437 chr10:1231002 ADARB2 -0.36 -6.39 -0.33 5.73e-10 Obesity-related traits; CRC cis rs7914558 0.966 rs11191518 chr10:104782853 C/G cg15744005 chr10:104629667 AS3MT -0.32 -6.87 -0.35 3.16e-11 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs875971 0.638 rs6960778 chr7:66071597 C/T cg18876405 chr7:65276391 NA -0.61 -10.89 -0.51 8.67e-24 Aortic root size; CRC cis rs4073416 0.707 rs8003811 chr14:66211250 C/T cg03016385 chr14:66212404 NA -0.42 -5.77 -0.3 1.8e-8 N-glycan levels; CRC cis rs875971 1.000 rs7792762 chr7:66004138 T/C cg18876405 chr7:65276391 NA 0.51 8.51 0.42 6.32e-16 Aortic root size; CRC trans rs208515 0.525 rs10944870 chr6:66687757 G/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.93 11.87 0.55 2.81e-27 Exhaled nitric oxide levels; CRC cis rs4654899 0.802 rs7517642 chr1:21252696 T/C cg02927042 chr1:21476669 EIF4G3 -0.5 -7.8 -0.4 8.23e-14 Superior frontal gyrus grey matter volume; CRC cis rs10504229 0.906 rs7003285 chr8:58173108 A/G cg05313129 chr8:58192883 C8orf71 -0.47 -6.99 -0.36 1.49e-11 Developmental language disorder (linguistic errors); CRC cis rs2204008 0.684 rs11514164 chr12:38036494 C/T cg26384229 chr12:38710491 ALG10B 0.67 9.3 0.46 2.04e-18 Bladder cancer; CRC cis rs911119 1.000 rs5030707 chr20:23618656 C/G cg16589663 chr20:23618590 CST3 0.62 8.01 0.4 2.01e-14 Chronic kidney disease; CRC trans rs1997103 0.765 rs55686950 chr7:55396552 A/C cg20935933 chr6:143382018 AIG1 0.52 6.73 0.35 7.57e-11 QRS interval (sulfonylurea treatment interaction); CRC cis rs3741151 0.773 rs73544716 chr11:73170061 C/T cg17517138 chr11:73019481 ARHGEF17 1.04 8.44 0.42 1.01e-15 GIP levels in response to oral glucose tolerance test (120 minutes); CRC cis rs7487075 0.820 rs10880953 chr12:46725869 A/T cg22049899 chr12:47219821 SLC38A4 0.33 6.35 0.33 7.05e-10 Itch intensity from mosquito bite; CRC cis rs870825 0.616 rs4519838 chr4:185628457 A/G cg04058563 chr4:185651563 MLF1IP 0.72 9.27 0.46 2.51e-18 Blood protein levels; CRC cis rs10924970 0.967 rs2382617 chr1:235402230 A/G cg26050004 chr1:235667680 B3GALNT2 0.38 5.68 0.3 3.02e-8 Asthma; CRC cis rs3020333 0.875 rs2982570 chr6:152013748 C/T cg22157087 chr6:152012887 ESR1 0.53 7.87 0.4 5.16e-14 Total body bone mineral density; CRC cis rs561341 0.882 rs72825748 chr17:30367396 G/A cg23018236 chr17:30244563 NA -0.67 -8.08 -0.41 1.25e-14 Hip circumference adjusted for BMI; CRC cis rs1348850 0.632 rs1358328 chr2:178517532 G/A cg22681709 chr2:178499509 PDE11A -0.5 -9.24 -0.45 3.26e-18 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs7772486 0.558 rs2142978 chr6:146012061 T/C cg23711669 chr6:146136114 FBXO30 -0.62 -8.93 -0.44 3.13e-17 Lobe attachment (rater-scored or self-reported); CRC cis rs6951245 0.572 rs79396675 chr7:1055047 C/T cg26224354 chr7:1096374 C7orf50;GPR146 -0.96 -8.21 -0.41 4.97e-15 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs11098499 0.731 rs9995026 chr4:120490499 T/A cg24375607 chr4:120327624 NA 0.49 7.29 0.37 2.32e-12 Corneal astigmatism; CRC cis rs1862618 0.671 rs28397234 chr5:56248428 T/G cg03609598 chr5:56110824 MAP3K1 0.58 8.02 0.4 1.82e-14 Initial pursuit acceleration; CRC cis rs4713675 0.565 rs4713674 chr6:33708169 C/T cg14003231 chr6:33640908 ITPR3 -0.46 -7.68 -0.39 1.81e-13 Plateletcrit; CRC cis rs35110281 0.626 rs162389 chr21:44936227 T/C cg01579765 chr21:45077557 HSF2BP -0.37 -6.83 -0.35 4.05e-11 Mean corpuscular volume; CRC cis rs758324 0.853 rs10051653 chr5:131248894 G/A cg25547332 chr5:131281432 NA -0.36 -5.68 -0.3 2.9e-8 Alzheimer's disease in APOE e4- carriers; CRC cis rs2739330 0.828 rs5760107 chr22:24252597 T/C cg23131131 chr22:24373011 LOC391322 -0.64 -9.86 -0.48 2.95e-20 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs1799949 1.000 rs8176133 chr17:41257458 A/C cg05368731 chr17:41323189 NBR1 0.66 9.6 0.47 2.07e-19 Menopause (age at onset); CRC cis rs637571 0.522 rs1786175 chr11:65754808 G/A cg26695010 chr11:65641043 EFEMP2 -0.4 -6.11 -0.32 2.83e-9 Eosinophil percentage of white cells; CRC cis rs9399137 0.507 rs28384513 chr6:135376209 T/G cg24558204 chr6:135376177 HBS1L 0.6 8.89 0.44 4.04e-17 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; CRC cis rs6598955 0.543 rs17163720 chr1:26549399 A/G cg04990556 chr1:26633338 UBXN11 -0.88 -10.63 -0.51 7.18e-23 Obesity-related traits; CRC cis rs4713118 0.615 rs9295747 chr6:27736993 G/T cg12172441 chr6:28176163 NA -0.47 -6.43 -0.33 4.47e-10 Parkinson's disease; CRC cis rs12681288 0.578 rs10503154 chr8:969343 C/G cg15309053 chr8:964076 NA 0.46 7.59 0.39 3.24e-13 Schizophrenia; CRC cis rs1129187 0.755 rs9471982 chr6:42935998 G/A cg05552183 chr6:42928497 GNMT 0.5 7.65 0.39 2.3e-13 Alzheimer's disease in APOE e4+ carriers; CRC trans rs948562 0.947 rs76985515 chr11:58371794 T/C cg26660744 chr1:1573181 CDK11B 0.54 6.1 0.32 2.94e-9 Lymphoma; CRC cis rs514406 0.679 rs12563825 chr1:53238324 G/T cg25767906 chr1:53392781 SCP2 0.53 8.35 0.42 1.91e-15 Monocyte count; CRC cis rs1401999 1.000 rs939338 chr3:183704068 A/G cg01324343 chr3:183735012 ABCC5 -0.8 -14.59 -0.63 1.64e-37 Anterior chamber depth; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg05588757 chr2:95825608 ZNF514 0.37 6.01 0.31 4.8e-9 Liver disease severity in Alagille syndrome; CRC cis rs2836974 0.623 rs34240248 chr21:40685239 A/G cg06238570 chr21:40685208 BRWD1 -0.87 -13.75 -0.6 2.54e-34 Cognitive function; CRC cis rs600626 0.636 rs11236517 chr11:75452721 T/C cg24262691 chr11:75473276 NA 0.54 7.42 0.38 1.04e-12 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CRC cis rs1707322 0.682 rs28508523 chr1:46189625 G/A cg03146154 chr1:46216737 IPP 0.64 9.31 0.46 1.85e-18 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs6500395 1.000 rs12597569 chr16:48693342 C/T cg04672837 chr16:48644449 N4BP1 -0.45 -6.63 -0.34 1.38e-10 Response to tocilizumab in rheumatoid arthritis; CRC cis rs12701220 0.894 rs12701348 chr7:1039457 C/T cg02733842 chr7:1102375 C7orf50 -0.79 -9.91 -0.48 1.94e-20 Bronchopulmonary dysplasia; CRC cis rs1656402 0.953 rs1190441 chr2:233422237 C/T cg03852847 chr2:233439513 NA -0.44 -7.45 -0.38 8.11e-13 Non-small cell lung cancer (survival); CRC cis rs807669 0.505 rs28651174 chr22:19236489 C/T cg02655711 chr22:19163373 SLC25A1 0.5 8.17 0.41 6.81e-15 Metabolite levels; CRC trans rs11148252 0.669 rs61958050 chr13:52994427 A/C cg18335740 chr13:41363409 SLC25A15 0.5 7.09 0.36 8.48e-12 Lewy body disease; CRC cis rs1008375 1.000 rs7673500 chr4:17621383 C/T cg16339924 chr4:17578868 LAP3 0.54 7.21 0.37 3.77e-12 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs4975616 0.836 rs13178866 chr5:1323212 C/T cg26373071 chr5:1325741 CLPTM1L 0.53 9.57 0.47 2.67e-19 Lung cancer; CRC trans rs1945213 0.694 rs9888298 chr11:55865704 T/C cg15704280 chr7:45808275 SEPT13 0.56 6.25 0.33 1.25e-9 Acute lymphoblastic leukemia (childhood); CRC cis rs13108904 0.935 rs1620928 chr4:1279124 C/T cg20887711 chr4:1340912 KIAA1530 -0.49 -7.26 -0.37 2.89e-12 Obesity-related traits; CRC trans rs7395662 0.791 rs7945791 chr11:48936340 C/T cg21153622 chr11:89784906 NA 0.47 7.44 0.38 8.86e-13 HDL cholesterol; CRC cis rs7221595 0.877 rs7219437 chr17:4050138 A/G cg09597638 chr17:3907349 NA 0.4 5.65 0.3 3.43e-8 Functional impairment in major depressive disorder, bipolar disorder and schizophrenia; CRC cis rs3820928 0.845 rs13415319 chr2:227878936 G/C cg11843606 chr2:227700838 RHBDD1 -0.39 -5.62 -0.3 4.16e-8 Pulmonary function; CRC cis rs10992471 0.605 rs7872375 chr9:95064843 C/G cg14631576 chr9:95140430 CENPP -0.3 -5.76 -0.3 1.92e-8 Visceral adipose tissue/subcutaneous adipose tissue ratio; CRC cis rs11212617 0.967 rs2356802 chr11:108282169 A/G cg14761454 chr11:108092087 ATM;NPAT 0.45 6.89 0.36 2.79e-11 Response to metformin in type 2 diabetes (glycemic); CRC cis rs4713118 0.513 rs149942 chr6:28001610 T/C cg02683197 chr6:28174875 NA 0.59 8.24 0.41 4.23e-15 Parkinson's disease; CRC trans rs7615952 0.546 rs2976733 chr3:125414138 T/C cg17147758 chr8:6949321 NA -0.52 -7.35 -0.38 1.6e-12 Blood pressure (smoking interaction); CRC cis rs12347191 0.500 rs925486 chr9:100619733 C/T cg13688889 chr9:100608707 NA -0.48 -6.09 -0.32 3.2e-9 Orofacial clefts; CRC cis rs31872 0.597 rs31874 chr5:140369318 C/T cg08985570 chr5:140589751 PCDHB12 -0.39 -5.73 -0.3 2.25e-8 Visceral adipose tissue adjusted for BMI; CRC cis rs6681460 1.000 rs6656912 chr1:67083671 A/G cg02459107 chr1:67143332 SGIP1 0.35 5.83 0.31 1.33e-8 Presence of antiphospholipid antibodies; CRC cis rs9287719 0.967 rs6727768 chr2:10757479 T/C cg00105475 chr2:10696890 NA 0.44 7.03 0.36 1.16e-11 Prostate cancer; CRC cis rs4713118 0.513 rs9368547 chr6:28028067 A/G cg15845792 chr6:28175446 NA 0.8 11.85 0.55 3.22e-27 Parkinson's disease; CRC cis rs2797160 1.000 rs2797158 chr6:126009398 G/A cg05901451 chr6:126070800 HEY2 0.4 6.2 0.32 1.65e-9 Endometrial cancer; CRC cis rs73200209 0.744 rs11615877 chr12:116709800 C/T cg01776926 chr12:116560359 MED13L -0.62 -7.31 -0.37 2.11e-12 Total body bone mineral density; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg03276813 chr2:182757157 SSFA2 0.5 6.51 0.34 2.86e-10 Thyroid stimulating hormone; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg10169971 chr6:83902988 RWDD2A;PGM3 0.37 6.23 0.32 1.4e-9 Liver disease severity in Alagille syndrome; CRC cis rs8180040 0.966 rs1872164 chr3:47415100 G/A cg27129171 chr3:47204927 SETD2 -0.6 -9.43 -0.46 7.56e-19 Colorectal cancer; CRC cis rs2762353 0.524 rs9467596 chr6:25783022 A/G cg16482183 chr6:26056742 HIST1H1C -0.52 -7.17 -0.37 4.84e-12 Blood metabolite levels; CRC cis rs875971 0.862 rs778686 chr7:65835910 C/T cg12463550 chr7:65579703 CRCP 0.52 7.35 0.38 1.57e-12 Aortic root size; CRC cis rs12908161 1.000 rs58416181 chr15:85264461 G/A cg17507749 chr15:85114479 UBE2QP1 0.63 8.96 0.44 2.45e-17 Schizophrenia; CRC cis rs7394190 0.748 rs11000780 chr10:75559077 G/A cg07699608 chr10:75541558 CHCHD1 0.67 6.65 0.34 1.19e-10 Incident atrial fibrillation; CRC cis rs1799949 1.000 rs9646412 chr17:41425893 A/T cg05368731 chr17:41323189 NBR1 0.64 9.28 0.46 2.43e-18 Menopause (age at onset); CRC cis rs523522 0.962 rs55848094 chr12:120966659 G/A cg27279351 chr12:120934652 DYNLL1 0.78 11.48 0.53 7.05e-26 High light scatter reticulocyte count; CRC cis rs9910055 0.718 rs7212854 chr17:42254417 A/G cg16434002 chr17:42200994 HDAC5 -0.47 -6.39 -0.33 5.78e-10 Total body bone mineral density; CRC cis rs9322193 0.923 rs9371486 chr6:150153226 T/C cg07701084 chr6:150067640 NUP43 0.57 7.77 0.39 1.01e-13 Lung cancer; CRC cis rs4478858 0.698 rs11802155 chr1:31805012 T/C cg00250761 chr1:31883323 NA -0.44 -8.5 -0.42 6.71e-16 Alcohol dependence; CRC cis rs17270561 0.636 rs9379782 chr6:25715023 G/A cg17691542 chr6:26056736 HIST1H1C 0.66 8.32 0.42 2.44e-15 Iron status biomarkers; CRC cis rs1552244 1.000 rs9820598 chr3:10117912 C/G cg02579736 chr3:10068473 FANCD2;CIDECP 0.97 13.2 0.59 3.17e-32 Alzheimer's disease; CRC cis rs2124969 0.548 rs62175388 chr2:161019664 G/A cg03641300 chr2:160917029 PLA2R1 -0.65 -8.34 -0.42 2.08e-15 Waist circumference adjusted for body mass index; CRC cis rs6460942 0.915 rs10267801 chr7:12451931 G/A cg06484146 chr7:12443880 VWDE -0.71 -8.1 -0.41 1.11e-14 Coronary artery disease; CRC cis rs769267 1.000 rs2074089 chr19:19449603 G/A cg01262667 chr19:19385393 TM6SF2 -0.38 -6.28 -0.33 1.07e-9 Tonsillectomy; CRC cis rs2224391 0.911 rs6925249 chr6:5262510 G/T cg09085698 chr6:5261316 LYRM4;FARS2 -0.43 -5.61 -0.3 4.38e-8 Height; CRC cis rs6500602 0.727 rs8051389 chr16:4570570 C/T cg14951292 chr16:4525986 HMOX2;NMRAL1 0.58 8.83 0.44 6.16e-17 Schizophrenia; CRC cis rs68170813 0.559 rs12536603 chr7:107002573 T/C cg02696742 chr7:106810147 HBP1 -0.56 -6.09 -0.32 3.13e-9 Coronary artery disease; CRC cis rs9292777 0.865 rs6888952 chr5:40412466 A/G cg09067459 chr5:40385259 NA 0.51 8.86 0.44 4.94e-17 Crohn's disease;Multiple sclerosis; CRC cis rs7771547 0.542 rs597153 chr6:36395997 C/T cg07856975 chr6:36356162 ETV7 0.4 5.91 0.31 8.7e-9 Platelet distribution width; CRC trans rs7615952 0.932 rs7629977 chr3:125649573 T/G cg07211511 chr3:129823064 LOC729375 -1.06 -18.13 -0.71 2.03e-51 Blood pressure (smoking interaction); CRC cis rs2070488 0.775 rs11926767 chr3:38527913 A/G cg01465620 chr3:38496096 LOC100128640;ACVR2B -0.69 -11.34 -0.53 2.23e-25 Electrocardiographic conduction measures; CRC cis rs916888 0.610 rs199436 chr17:44789285 C/T cg15921436 chr17:44337874 NA -0.51 -6.57 -0.34 1.95e-10 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs7408868 0.831 rs7245850 chr19:15274585 A/C cg14696996 chr19:15285081 NOTCH3 0.96 8.82 0.44 6.74e-17 Pulse pressure; CRC cis rs270601 0.909 rs2569265 chr5:131704519 T/C cg04518342 chr5:131593106 PDLIM4 -0.44 -7.08 -0.36 8.93e-12 Acylcarnitine levels; CRC cis rs868943 0.582 rs12209747 chr6:116452561 A/G cg15226275 chr6:116381976 FRK 0.26 6.14 0.32 2.37e-9 Total cholesterol levels; CRC cis rs7727544 0.507 rs10051679 chr5:131570931 T/A cg04518342 chr5:131593106 PDLIM4 0.51 9.12 0.45 7.89e-18 Blood metabolite levels; CRC trans rs11088226 0.681 rs16989507 chr21:33939509 T/G cg09050820 chr6:167586206 TCP10L2 0.81 8.55 0.43 4.61e-16 Gastritis; CRC cis rs2730260 0.537 rs56023468 chr7:158875329 T/C cg02254261 chr7:158964346 NA -0.54 -6.07 -0.32 3.6e-9 Myopia (pathological); CRC cis rs6835098 1.000 rs2332654 chr4:174088399 C/T cg08422745 chr4:174089978 GALNT7 -0.97 -16.54 -0.67 3.64e-45 Dementia and core Alzheimer's disease neuropathologic changes; CRC trans rs3858526 0.959 rs11039540 chr11:5928334 C/T cg01505111 chr6:125621795 HDDC2 0.4 6.42 0.33 4.73e-10 DNA methylation (variation); CRC cis rs1451375 0.698 rs11238214 chr7:50636018 A/G cg18232548 chr7:50535776 DDC 0.44 6.25 0.33 1.26e-9 Malaria; CRC cis rs6743376 0.556 rs1374285 chr2:113818738 G/A cg24553058 chr2:113831203 IL1F10 0.43 6.96 0.36 1.81e-11 Inflammatory biomarkers; CRC cis rs798554 0.644 rs1639040 chr7:2884116 G/T cg13628971 chr7:2884303 GNA12 0.6 8.31 0.42 2.51e-15 Height; CRC cis rs1882538 0.512 rs13241734 chr7:133122742 C/G cg10665199 chr7:133106180 EXOC4 0.68 10.47 0.5 2.54e-22 Intelligence (multi-trait analysis); CRC cis rs858239 1.000 rs858239 chr7:23286315 G/A cg00469287 chr7:23338798 C7orf30 0.42 5.63 0.3 3.89e-8 Cerebrospinal fluid biomarker levels; CRC cis rs11122272 0.603 rs2998427 chr1:231528112 A/G cg06096015 chr1:231504339 EGLN1 0.41 6.15 0.32 2.31e-9 Hemoglobin concentration; CRC cis rs1707322 0.963 rs6429581 chr1:46319096 G/A cg03146154 chr1:46216737 IPP 0.58 8.14 0.41 8.04e-15 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs7267979 0.903 rs6050482 chr20:25226327 C/T cg24626310 chr20:25276739 ABHD12;PYGB 0.34 5.76 0.3 1.92e-8 Liver enzyme levels (alkaline phosphatase); CRC cis rs1728785 0.901 rs933713 chr16:68581378 C/A cg02972257 chr16:68554789 NA -0.58 -7.24 -0.37 3.21e-12 Ulcerative colitis; CRC cis rs35520189 0.796 rs1143627 chr2:113594387 C/T cg12858261 chr2:113808755 IL1F8 -0.42 -6.61 -0.34 1.58e-10 Obstructive sleep apnea trait (apnea hypopnea index); CRC cis rs7224737 1.000 rs2285657 chr17:40272594 C/A cg02228675 chr17:40259724 DHX58 -0.49 -6.92 -0.36 2.42e-11 Fibrinogen levels; CRC cis rs4713675 0.584 rs4713666 chr6:33679061 A/G cg14003231 chr6:33640908 ITPR3 0.49 7.82 0.4 7.19e-14 Plateletcrit; CRC trans rs7395662 0.791 rs12273724 chr11:48845710 G/A cg21153622 chr11:89784906 NA 0.45 7.24 0.37 3.21e-12 HDL cholesterol; CRC cis rs11229555 0.598 rs12269888 chr11:58184336 T/C cg15696309 chr11:58395628 NA -0.81 -10.31 -0.49 8.83e-22 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; CRC cis rs4964805 0.657 rs73192049 chr12:104187993 T/C cg02344784 chr12:104178138 NT5DC3 0.79 15.0 0.64 4.21e-39 Attention deficit hyperactivity disorder; CRC cis rs6496044 0.568 rs1982743 chr15:86068759 A/T cg17133734 chr15:86042851 AKAP13 0.39 6.31 0.33 9.23e-10 Interstitial lung disease; CRC cis rs4713118 0.513 rs149975 chr6:27986340 G/A cg23161317 chr6:28129485 ZNF389 0.45 6.31 0.33 8.83e-10 Parkinson's disease; CRC cis rs2976388 0.647 rs2572906 chr8:143798269 G/A cg22687807 chr8:143858763 LYNX1 0.49 8.85 0.44 5.36e-17 Urinary tract infection frequency; CRC trans rs11098499 0.863 rs10004484 chr4:120442428 C/T cg25214090 chr10:38739885 LOC399744 0.64 10.07 0.49 5.61e-21 Corneal astigmatism; CRC cis rs2625529 0.652 rs2899775 chr15:72268354 C/T cg16672083 chr15:72433130 SENP8 0.48 7.16 0.37 5.44e-12 Red blood cell count; CRC cis rs6534441 0.697 rs56194872 chr4:125418343 G/T cg21609808 chr4:125404261 NA 0.45 6.38 0.33 6.04e-10 Major depressive disorder; CRC cis rs1552244 0.572 rs59074548 chr3:10164347 G/C cg02579736 chr3:10068473 FANCD2;CIDECP 1.01 11.58 0.54 2.98e-26 Alzheimer's disease; CRC cis rs9814567 0.964 rs1534028 chr3:134284639 G/C cg06541857 chr3:134203789 ANAPC13;CEP63 -0.4 -5.99 -0.31 5.53e-9 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs9322193 0.884 rs1125 chr6:149979416 G/A cg13206674 chr6:150067644 NUP43 0.68 9.64 0.47 1.52e-19 Lung cancer; CRC cis rs4073416 0.542 rs2411815 chr14:66020071 A/T cg03016385 chr14:66212404 NA 0.42 5.78 0.3 1.69e-8 N-glycan levels; CRC cis rs561341 1.000 rs8073186 chr17:30244956 T/C cg00745463 chr17:30367425 LRRC37B -0.57 -6.99 -0.36 1.55e-11 Hip circumference adjusted for BMI; CRC cis rs4713118 0.869 rs6901520 chr6:27714575 G/T cg12273811 chr6:28175739 NA 0.54 7.7 0.39 1.59e-13 Parkinson's disease; CRC trans rs9858542 0.953 rs7623659 chr3:49414791 C/T cg21659725 chr3:3221576 CRBN -0.65 -8.96 -0.44 2.56e-17 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs3806843 0.676 rs778591 chr5:140025484 G/A cg19875535 chr5:140030758 IK -0.66 -11.47 -0.53 7.41e-26 Depressive symptoms (multi-trait analysis); CRC trans rs16846053 0.786 rs72877309 chr2:162587828 A/G cg03774468 chr3:140950104 ACPL2 -0.66 -6.02 -0.31 4.63e-9 Blood osmolality (transformed sodium); CRC cis rs10504229 0.683 rs16921819 chr8:58107936 G/T cg22535103 chr8:58192502 C8orf71 -0.69 -8.8 -0.44 7.79e-17 Developmental language disorder (linguistic errors); CRC cis rs13118159 0.550 rs10016557 chr4:1363628 C/T cg02018176 chr4:1364513 KIAA1530 -0.72 -12.28 -0.56 8.34e-29 Longevity; CRC cis rs977987 0.806 rs4888404 chr16:75428097 G/A cg03315344 chr16:75512273 CHST6 0.54 9.0 0.44 1.86e-17 Dupuytren's disease; CRC cis rs950169 0.922 rs4338765 chr15:84916836 G/T cg11189052 chr15:85197271 WDR73 0.63 8.96 0.44 2.38e-17 Schizophrenia; CRC cis rs9925964 0.967 rs1549293 chr16:31141993 C/T cg03418659 chr16:31128414 MYST1 0.54 7.86 0.4 5.55e-14 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs597539 0.652 rs579136 chr11:68637476 C/G cg04772025 chr11:68637568 NA 0.51 8.11 0.41 1.04e-14 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs9463078 0.683 rs1418433 chr6:44752568 C/T cg25276700 chr6:44698697 NA 0.25 5.94 0.31 7.11e-9 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; CRC trans rs6076960 0.629 rs6054024 chr20:6229282 A/C cg17788362 chr6:86352627 SYNCRIP 0.5 6.88 0.35 3e-11 Smooth-surface caries; CRC trans rs1005277 0.579 rs2474587 chr10:38420666 C/T cg27523141 chr10:43048294 ZNF37B 0.48 6.99 0.36 1.56e-11 Extrinsic epigenetic age acceleration; CRC cis rs17376456 0.825 rs13165400 chr5:93091427 G/A cg21475434 chr5:93447410 FAM172A 0.71 6.79 0.35 5.34e-11 Diabetic retinopathy; CRC cis rs4481887 0.597 rs6587475 chr1:248578622 C/T cg00666640 chr1:248458726 OR2T12 0.38 6.58 0.34 1.81e-10 Common traits (Other); CRC cis rs7666738 0.830 rs28451001 chr4:98924544 T/A cg17366294 chr4:99064904 C4orf37 0.43 7.32 0.37 1.95e-12 Colonoscopy-negative controls vs population controls; CRC cis rs2739330 0.796 rs2154594 chr22:24254055 A/G cg10819733 chr22:24237672 NA 0.36 6.17 0.32 2.06e-9 Liver enzyme levels (gamma-glutamyl transferase); CRC trans rs1005277 0.602 rs1740743 chr10:38519222 C/T cg17830980 chr10:43048298 ZNF37B -0.57 -9.68 -0.47 1.16e-19 Extrinsic epigenetic age acceleration; CRC trans rs9467711 1.000 rs9467708 chr6:26327956 T/C cg15845792 chr6:28175446 NA 0.66 6.42 0.33 4.88e-10 Autism spectrum disorder or schizophrenia; CRC cis rs897984 0.542 rs11865038 chr16:31095171 C/T cg02466173 chr16:30829666 NA -0.59 -8.97 -0.44 2.32e-17 Dementia with Lewy bodies; CRC cis rs6121246 0.567 rs6060263 chr20:30193110 T/C cg18721089 chr20:30220636 NA -0.52 -7.93 -0.4 3.54e-14 Mean corpuscular hemoglobin; CRC cis rs9916302 0.851 rs12936996 chr17:37665554 A/G cg03013999 chr17:37608204 MED1 -0.45 -6.87 -0.35 3.16e-11 Glomerular filtration rate (creatinine); CRC cis rs270601 0.710 rs4705852 chr5:131602807 A/G cg20512303 chr5:131592959 PDLIM4 0.4 7.55 0.38 4.36e-13 Acylcarnitine levels; CRC cis rs7591163 1.000 rs4487084 chr2:228713179 G/A cg23807890 chr2:228736357 WDR69 -0.51 -6.99 -0.36 1.56e-11 Blood pressure; CRC cis rs8180040 1.000 rs8180040 chr3:47388947 A/T cg13451127 chr3:47050803 NBEAL2 0.21 5.64 0.3 3.61e-8 Colorectal cancer; CRC cis rs6743376 0.556 rs1800930 chr2:113820530 A/G cg24553058 chr2:113831203 IL1F10 0.44 7.18 0.37 4.61e-12 Inflammatory biomarkers; CRC cis rs1552244 0.572 rs6797536 chr3:10168802 C/T cg13047869 chr3:10149882 C3orf24 -0.53 -6.58 -0.34 1.82e-10 Alzheimer's disease; CRC trans rs1945213 0.694 rs1384088 chr11:55848713 G/C cg03929089 chr4:120376271 NA -0.6 -6.96 -0.36 1.79e-11 Acute lymphoblastic leukemia (childhood); CRC trans rs861318 0.838 rs855866 chr1:159052720 A/G cg00508575 chr12:90050967 ATP2B1 -0.43 -6.01 -0.31 4.95e-9 Obesity-related traits; CRC cis rs9341808 0.500 rs2322629 chr6:80811540 C/T cg08355045 chr6:80787529 NA 0.39 6.6 0.34 1.64e-10 Sitting height ratio; CRC cis rs7567389 0.704 rs4662714 chr2:127995213 A/G cg09760422 chr2:128146352 NA -0.39 -7.44 -0.38 8.74e-13 Self-rated health; CRC cis rs7274811 0.681 rs291707 chr20:31964256 G/A cg03904042 chr20:32255491 NECAB3;C20orf134 0.44 6.39 0.33 5.52e-10 Height; CRC cis rs3015497 0.648 rs10144512 chr14:51082271 A/C cg09863266 chr14:51125203 SAV1 -0.31 -5.87 -0.31 1.08e-8 Mean platelet volume; CRC cis rs1129187 0.837 rs3763236 chr6:42902508 C/T cg27588902 chr6:42928151 GNMT 0.37 6.68 0.35 1.04e-10 Alzheimer's disease in APOE e4+ carriers; CRC cis rs6570726 0.791 rs1509213 chr6:145783360 G/A cg23711669 chr6:146136114 FBXO30 -0.72 -12.51 -0.57 1.19e-29 Lobe attachment (rater-scored or self-reported); CRC cis rs7829975 0.742 rs1533059 chr8:8684953 A/G cg06636001 chr8:8085503 FLJ10661 -0.55 -8.12 -0.41 9.51e-15 Mood instability; CRC cis rs10946940 1.000 rs10946940 chr6:27560587 A/G cg15845792 chr6:28175446 NA -0.47 -6.51 -0.34 2.78e-10 Systemic lupus erythematosus; CRC cis rs9393692 0.645 rs766406 chr6:26319588 G/T cg00631329 chr6:26305371 NA -0.73 -12.86 -0.58 6.22e-31 Educational attainment; CRC cis rs2762353 0.595 rs12200838 chr6:25753603 C/T cg07061783 chr6:25882402 NA 0.49 6.32 0.33 8.31e-10 Blood metabolite levels; CRC cis rs2795502 1.000 rs2795502 chr10:43340662 G/A cg20628663 chr10:43360327 NA -0.69 -10.8 -0.51 1.83e-23 Blood protein levels; CRC cis rs9467711 0.606 rs9379856 chr6:26366836 A/C cg14345882 chr6:26364793 BTN3A2 0.65 5.74 0.3 2.17e-8 Autism spectrum disorder or schizophrenia; CRC cis rs10256972 0.681 rs12702016 chr7:1129392 C/T cg07308232 chr7:1071921 C7orf50 -0.46 -6.3 -0.33 9.71e-10 Longevity;Endometriosis; CRC trans rs9217 1.000 rs11658168 chr17:7406134 C/T cg08566640 chr11:64091735 NA -0.42 -6.68 -0.35 1.03e-10 Height; CRC cis rs2836950 0.585 rs1029004 chr21:40615343 A/G cg11644478 chr21:40555479 PSMG1 -0.48 -7.1 -0.36 7.95e-12 Menarche (age at onset); CRC cis rs7727544 0.548 rs4705938 chr5:131694077 A/G cg14196790 chr5:131705035 SLC22A5 0.33 5.67 0.3 3.16e-8 Blood metabolite levels; CRC cis rs939584 0.877 rs62105307 chr2:633661 A/G cg03610516 chr2:642275 NA 0.42 5.65 0.3 3.49e-8 Body mass index; CRC cis rs11583043 1.000 rs7541397 chr1:101322866 C/T cg16556008 chr1:101360663 SLC30A7;EXTL2 -0.57 -7.59 -0.39 3.42e-13 Ulcerative colitis;Inflammatory bowel disease; CRC cis rs12348691 0.503 rs7849834 chr9:100606188 T/C cg13688889 chr9:100608707 NA -0.47 -6.03 -0.32 4.44e-9 Alopecia areata; CRC cis rs8177179 0.505 rs1405023 chr3:133481128 T/C cg11941060 chr3:133502564 NA 0.41 6.54 0.34 2.36e-10 Iron status biomarkers (transferrin levels); CRC cis rs9368481 1.000 rs9368481 chr6:26961761 C/T cg07220782 chr6:26987966 LOC100270746;C6orf41 -0.41 -5.72 -0.3 2.44e-8 Autism spectrum disorder or schizophrenia; CRC cis rs6076065 0.723 rs2424546 chr20:23391751 G/T cg11657817 chr20:23433608 CST11 0.43 6.32 0.33 8.28e-10 Facial morphology (factor 15, philtrum width); CRC cis rs243505 1.000 rs243521 chr7:148421571 T/C cg09806900 chr7:148480153 CUL1 -0.44 -6.24 -0.33 1.31e-9 Inflammatory bowel disease;Crohn's disease; CRC cis rs2969070 0.831 rs10279360 chr7:2503998 T/C cg03277898 chr7:2518824 NA -0.42 -6.12 -0.32 2.64e-9 Diastolic blood pressure; CRC cis rs2153535 0.601 rs9502715 chr6:8455709 C/T cg21535247 chr6:8435926 SLC35B3 0.5 7.5 0.38 5.81e-13 Motion sickness; CRC cis rs1670533 1.000 rs10084890 chr4:1053934 C/G cg27284194 chr4:1044797 NA -0.48 -6.23 -0.32 1.44e-9 Recombination rate (females); CRC cis rs3820068 0.705 rs72643694 chr1:15860185 C/T cg27534772 chr1:16042836 PLEKHM2 0.43 7.23 0.37 3.45e-12 Systolic blood pressure; CRC cis rs10781543 0.845 rs10781542 chr9:139327439 A/G cg14019695 chr9:139328340 INPP5E 0.41 6.08 0.32 3.36e-9 Monocyte percentage of white cells; CRC cis rs62064224 0.714 rs62064225 chr17:30635429 C/T cg09324608 chr17:30823087 MYO1D 0.36 6.31 0.33 9.25e-10 Schizophrenia; CRC cis rs7635838 0.590 rs2256773 chr3:11386329 C/G cg00170343 chr3:11313890 ATG7 0.46 7.12 0.37 6.81e-12 HDL cholesterol; CRC cis rs7843479 0.562 rs6988010 chr8:21859084 G/A cg16476235 chr8:21771668 DOK2 0.4 6.69 0.35 9.59e-11 Mean corpuscular volume; CRC trans rs637571 0.522 rs1151512 chr11:65757533 G/A cg17712092 chr4:129076599 LARP1B 0.69 11.55 0.54 3.91e-26 Eosinophil percentage of white cells; CRC cis rs11577318 0.853 rs11247913 chr1:26648551 G/C cg04990556 chr1:26633338 UBXN11 -0.45 -5.76 -0.3 1.94e-8 Granulocyte percentage of myeloid white cells; CRC cis rs9858542 0.537 rs9874474 chr3:49326178 A/G cg00383909 chr3:49044727 WDR6 0.66 7.34 0.37 1.74e-12 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs11190604 1.000 rs10786598 chr10:102291579 G/A cg07080220 chr10:102295463 HIF1AN 0.47 5.65 0.3 3.39e-8 Palmitoleic acid (16:1n-7) levels; CRC cis rs6502050 0.799 rs12603050 chr17:80104631 A/G cg11859384 chr17:80120422 CCDC57 -0.37 -5.85 -0.31 1.16e-8 Life satisfaction; CRC cis rs826838 0.754 rs2387920 chr12:38626351 A/G cg26384229 chr12:38710491 ALG10B 0.69 9.2 0.45 4.37e-18 Heart rate; CRC cis rs9467711 0.651 rs71557316 chr6:26072981 G/A cg08501292 chr6:25962987 TRIM38 0.87 8.24 0.41 4.22e-15 Autism spectrum disorder or schizophrenia; CRC cis rs11098499 0.691 rs12502524 chr4:120271414 G/A cg09307838 chr4:120376055 NA 0.6 9.3 0.46 1.95e-18 Corneal astigmatism; CRC cis rs10752881 1.000 rs10797813 chr1:182989366 C/T ch.1.3577855R chr1:183094577 LAMC1 0.86 15.17 0.64 8.93e-40 Colorectal cancer; CRC cis rs875971 0.964 rs6945019 chr7:65922458 C/G cg18876405 chr7:65276391 NA 0.51 8.7 0.43 1.58e-16 Aortic root size; CRC cis rs7572644 0.640 rs4564736 chr2:28069543 A/T cg27432699 chr2:27873401 GPN1 0.45 6.1 0.32 3.03e-9 Response to carboplatin and paclitaxel in ovarian cancer (Caspase 3/7 EC50); CRC cis rs459193 1.000 rs458741 chr5:55807837 T/C cg26646659 chr5:55776364 NA 0.48 6.64 0.34 1.29e-10 Coronary artery disease;Type 2 diabetes;Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);Waist-to-hip ratio adjusted for BMI in non-smokers;Waist-to-hip ratio adjusted for BMI (smoking interaction);Waist-to-hip ratio adjusted for body mass index;Waist-hip ratio;Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction); CRC cis rs9534288 0.797 rs9534283 chr13:46589256 C/A cg15192986 chr13:46630673 CPB2 -0.67 -9.81 -0.48 4.16e-20 Blood protein levels; CRC cis rs853679 0.517 rs4713141 chr6:28101678 G/C cg02683197 chr6:28174875 NA 0.85 10.52 0.5 1.71e-22 Depression; CRC cis rs4713118 0.513 rs183244 chr6:28031838 C/A cg12172441 chr6:28176163 NA 0.49 6.64 0.34 1.28e-10 Parkinson's disease; CRC trans rs963731 0.649 rs2305516 chr2:39198966 C/T cg13401531 chr11:70333281 SHANK2 -0.72 -6.17 -0.32 2.05e-9 Corticobasal degeneration; CRC cis rs3823572 0.564 rs2953618 chr7:133672476 G/C cg03336402 chr7:133662267 EXOC4 -0.68 -10.11 -0.49 4.29e-21 Intelligence (multi-trait analysis); CRC cis rs7943191 0.805 rs12226821 chr11:62369018 C/G cg11742103 chr11:62369870 EML3;MTA2 0.56 9.54 0.47 3.45e-19 Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction); CRC cis rs1552244 1.000 rs9809061 chr3:10085130 C/G cg00166722 chr3:10149974 C3orf24 0.67 9.23 0.45 3.37e-18 Alzheimer's disease; CRC cis rs2257205 0.667 rs8076021 chr17:56694646 T/G cg25885038 chr17:56607967 SEPT4 -0.53 -5.78 -0.3 1.72e-8 Pancreatic cancer; CRC cis rs4716602 0.596 rs10458244 chr7:156164285 C/T cg16983916 chr7:156159713 NA -0.39 -6.78 -0.35 5.69e-11 Anti-saccade response; CRC trans rs57221529 0.766 rs4081847 chr5:574072 C/T cg25482853 chr8:67687455 SGK3 1.21 14.96 0.64 5.79e-39 Lung disease severity in cystic fibrosis; CRC cis rs561341 1.000 rs72825740 chr17:30338356 A/G cg00745463 chr17:30367425 LRRC37B -0.88 -9.64 -0.47 1.51e-19 Hip circumference adjusted for BMI; CRC cis rs9916302 0.904 rs612194 chr17:37442707 T/A cg15445000 chr17:37608096 MED1 -0.42 -9.15 -0.45 5.94e-18 Glomerular filtration rate (creatinine); CRC cis rs2742417 1.000 rs2742432 chr3:45737467 G/T cg04837898 chr3:45731254 SACM1L -0.34 -5.68 -0.3 3.03e-8 Response to anti-depressant treatment in major depressive disorder; CRC cis rs12594515 1.000 rs6493175 chr15:45989898 T/C cg01629716 chr15:45996671 NA 0.41 8.46 0.42 9.03e-16 Waist circumference;Weight; CRC cis rs6582630 0.638 rs12424222 chr12:38548273 C/T cg13010199 chr12:38710504 ALG10B -0.42 -6.07 -0.32 3.55e-9 Drug-induced liver injury (flucloxacillin); CRC cis rs172166 0.516 rs1225715 chr6:28113373 C/T cg15845792 chr6:28175446 NA -0.58 -8.58 -0.43 3.76e-16 Cardiac Troponin-T levels; CRC trans rs1005277 0.579 rs2472175 chr10:38382901 T/G cg11292332 chr7:45801988 SEPT13 -0.35 -6.26 -0.33 1.23e-9 Extrinsic epigenetic age acceleration; CRC cis rs73206853 0.841 rs73191839 chr12:110967652 G/T cg12870014 chr12:110450643 ANKRD13A 0.81 8.45 0.42 9.67e-16 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC trans rs10983614 1.000 rs7867776 chr9:120072627 A/G cg17074213 chr1:92351695 TGFBR3 0.48 6.42 0.33 4.9e-10 Survival in pancreatic cancer; CRC cis rs13064411 0.696 rs11921931 chr3:113015091 G/A cg10517650 chr3:113235015 CCDC52 -0.38 -5.91 -0.31 8.52e-9 Response to simvastatin treatment (PCSK9 protein level change); CRC trans rs8073060 0.586 rs4796100 chr17:33997657 G/T cg19694781 chr19:47549865 TMEM160 1.07 15.31 0.65 2.62e-40 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; CRC cis rs4731207 0.596 rs10264766 chr7:124572916 T/A cg23710748 chr7:124431027 NA -0.44 -6.94 -0.36 2.09e-11 Cutaneous malignant melanoma; CRC cis rs7937682 0.847 rs583032 chr11:111432757 C/T cg09085632 chr11:111637200 PPP2R1B -0.94 -17.09 -0.69 2.69e-47 Primary sclerosing cholangitis; CRC trans rs13046373 0.905 rs4816372 chr21:32077414 A/T cg24344011 chr20:39666465 PRO0628;TOP1 -0.37 -6.23 -0.32 1.46e-9 HDL cholesterol; CRC cis rs908922 0.676 rs578382 chr1:152514054 A/G cg23254163 chr1:152506842 NA -0.44 -8.5 -0.42 6.92e-16 Hair morphology; CRC cis rs758324 0.773 rs4540167 chr5:131163022 G/A cg25547332 chr5:131281432 NA 0.37 5.91 0.31 8.53e-9 Alzheimer's disease in APOE e4- carriers; CRC cis rs11711311 1.000 rs9826808 chr3:113455644 A/G cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.52 -7.0 -0.36 1.47e-11 IgG glycosylation; CRC trans rs724568 0.681 rs1978656 chr2:67920009 A/G cg26386464 chr8:38033970 LSM1;BAG4 -0.41 -6.06 -0.32 3.71e-9 Major depressive disorder (broad); CRC cis rs3820928 0.904 rs1835159 chr2:227764057 A/G cg11843606 chr2:227700838 RHBDD1 -0.41 -5.87 -0.31 1.04e-8 Pulmonary function; CRC cis rs10256972 0.552 rs2949195 chr7:1202705 G/A cg22907277 chr7:1156413 C7orf50 0.65 9.98 0.48 1.12e-20 Longevity;Endometriosis; CRC cis rs6963495 0.745 rs73192153 chr7:105212418 A/T cg13798780 chr7:105162888 PUS7 0.63 7.16 0.37 5.16e-12 Bipolar disorder (body mass index interaction); CRC cis rs2075371 0.933 rs2544181 chr7:133944934 C/T cg11752832 chr7:134001865 SLC35B4 0.42 6.35 0.33 6.97e-10 Mean platelet volume; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg15726318 chr8:71315757 NCOA2 -0.36 -6.0 -0.31 5.24e-9 Myopia (pathological); CRC cis rs4665809 1.000 rs6720314 chr2:26334852 G/A cg22920501 chr2:26401640 FAM59B -0.56 -7.35 -0.38 1.55e-12 Gut microbiome composition (summer); CRC cis rs853679 0.517 rs12174753 chr6:28042465 C/G cg18032046 chr6:28092343 ZSCAN16 -0.5 -5.88 -0.31 9.88e-9 Depression; CRC cis rs9381040 0.674 rs3747742 chr6:41162518 C/T cg25110423 chr6:41068646 NFYA;LOC221442 0.5 7.7 0.39 1.5700000000000001e-13 Alzheimer's disease (late onset); CRC cis rs2346177 0.519 rs4563285 chr2:46669944 C/G cg26688816 chr2:46740690 ATP6V1E2 -0.58 -8.87 -0.44 4.6e-17 HDL cholesterol; CRC cis rs6752107 0.967 rs11680130 chr2:234157258 G/A cg07618928 chr2:234183455 ATG16L1;SCARNA5 0.65 10.96 0.52 4.72e-24 Crohn's disease;Inflammatory bowel disease; CRC cis rs1129187 0.719 rs3805953 chr6:42936900 C/T cg10862848 chr6:42927986 GNMT -0.4 -9.28 -0.46 2.4e-18 Alzheimer's disease in APOE e4+ carriers; CRC cis rs9611565 0.527 rs2234053 chr22:41777315 G/T cg06481639 chr22:41940642 POLR3H -0.5 -5.66 -0.3 3.31e-8 Vitiligo; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg24082730 chr3:126076366 KLF15 0.46 7.53 0.38 4.93e-13 Liver disease severity in Alagille syndrome; CRC trans rs13128441 0.593 rs4370072 chr4:5149543 C/T cg24266670 chr11:115630629 NA -0.4 -6.1 -0.32 3.01e-9 Celiac disease; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg05984320 chr8:144373269 ZNF696 0.46 6.33 0.33 7.96e-10 Anxiety disorder; CRC cis rs875971 0.862 rs10261398 chr7:65750164 A/G cg11764359 chr7:65958608 NA -0.6 -9.34 -0.46 1.49e-18 Aortic root size; CRC trans rs2821260 0.902 rs12131816 chr1:72529866 A/G cg22687382 chr19:2151882 AP3D1 -0.52 -6.36 -0.33 6.9e-10 Intelligence (multi-trait analysis); CRC cis rs4285028 0.699 rs1574115 chr3:121469225 T/C cg20356878 chr3:121714668 ILDR1 -0.49 -6.49 -0.34 3.23e-10 Multiple sclerosis; CRC cis rs7408868 0.831 rs11672004 chr19:15277282 T/A cg14696996 chr19:15285081 NOTCH3 0.53 5.93 0.31 7.74e-9 Pulse pressure; CRC cis rs7119 0.717 rs11629652 chr15:77779951 C/A cg05673287 chr15:77411982 SGK269 -0.54 -8.33 -0.42 2.27e-15 Type 2 diabetes; CRC cis rs67340775 0.541 rs200964 chr6:27866943 G/C cg15845792 chr6:28175446 NA 0.88 9.19 0.45 4.49e-18 Lung cancer in ever smokers; CRC cis rs62064224 0.614 rs4794921 chr17:30742310 C/T cg18200150 chr17:30822561 MYO1D 0.45 8.6 0.43 3.21e-16 Schizophrenia; CRC cis rs34293785 1.000 rs34293785 chr1:66137192 T/C cg04111102 chr1:66153794 NA 0.35 6.02 0.31 4.67e-9 Neutrophil percentage of white cells;Granulocyte percentage of myeloid white cells;Sum neutrophil eosinophil counts;Monocyte percentage of white cells;Sum basophil neutrophil counts;Neutrophil count;White blood cell count; CRC cis rs853679 0.599 rs188015 chr6:27877446 T/A cg15786705 chr6:28176104 NA 0.64 5.9 0.31 9.03e-9 Depression; CRC trans rs11581859 1.000 rs56027883 chr1:99311121 A/G cg12183875 chr3:169587454 LRRC31 0.25 5.96 0.31 6.55e-9 Response to cognitive-behavioural therapy in anxiety disorder; CRC cis rs1552244 0.882 rs2030564 chr3:10039044 A/G cg16606324 chr3:10149918 C3orf24 0.62 8.11 0.41 1e-14 Alzheimer's disease; CRC cis rs651907 0.535 rs34648996 chr3:101511202 A/G cg12386194 chr3:101231763 SENP7 0.52 7.54 0.38 4.53e-13 Colorectal cancer; CRC cis rs12995491 0.731 rs34991383 chr2:88500337 T/G cg18490616 chr2:88469792 THNSL2 -0.43 -6.17 -0.32 2.01e-9 Response to metformin (IC50); CRC cis rs7208859 0.623 rs9899692 chr17:29156939 C/T cg13385521 chr17:29058706 SUZ12P 0.65 7.4 0.38 1.15e-12 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC trans rs9825823 0.617 rs2083264 chr3:61074229 A/G ch.7.38331565R chr7:38365040 NA 0.42 6.32 0.33 8.7e-10 Depressive symptom measurement or major depressive disorder; CRC cis rs3760982 0.546 rs73048681 chr19:44289945 T/C cg11993925 chr19:44307056 LYPD5 0.72 12.73 0.57 1.87e-30 Breast cancer (estrogen-receptor negative);Breast cancer; CRC cis rs6951245 0.529 rs76001997 chr7:1152615 C/T cg21664854 chr7:1097933 C7orf50;GPR146 0.57 7.14 0.37 5.88e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs3809863 0.602 rs2317677 chr17:45393407 G/A cg08085267 chr17:45401833 C17orf57 -0.79 -12.8 -0.58 1.0500000000000001e-30 Glaucoma (primary open-angle); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg07769507 chr4:57844949 POLR2B;C4orf14 0.45 6.38 0.33 5.92e-10 Response to antipsychotic treatment; CRC cis rs8060686 0.641 rs7190079 chr16:68073834 G/A cg26727032 chr16:67993705 SLC12A4 -0.59 -6.53 -0.34 2.55e-10 HDL cholesterol;Metabolic syndrome; CRC cis rs7666738 0.830 rs9998682 chr4:98939009 T/C cg05340658 chr4:99064831 C4orf37 0.6 9.35 0.46 1.41e-18 Colonoscopy-negative controls vs population controls; CRC cis rs6952808 0.595 rs3778982 chr7:2166233 T/C cg22963979 chr7:1858916 MAD1L1 -0.46 -6.47 -0.34 3.57e-10 Bipolar disorder and schizophrenia; CRC cis rs9826463 0.582 rs11708870 chr3:142070013 A/G cg20824294 chr3:142316082 PLS1 0.35 5.67 0.3 3.1e-8 QRS duration in Tripanosoma cruzi seropositivity; CRC cis rs10788264 0.716 rs7091348 chr10:124016160 C/T cg09507567 chr10:124027408 NA 0.28 5.92 0.31 8.22e-9 Total body bone mineral density; CRC trans rs13315871 0.585 rs12107189 chr3:58349022 C/T cg25250853 chr2:85822726 RNF181 0.52 6.16 0.32 2.09e-9 Cholesterol, total; CRC cis rs9287719 0.967 rs6744599 chr2:10747013 C/G cg00105475 chr2:10696890 NA -0.45 -7.26 -0.37 2.81e-12 Prostate cancer; CRC cis rs9399135 0.967 rs11754783 chr6:135347661 T/A cg24558204 chr6:135376177 HBS1L 0.52 8.23 0.41 4.52e-15 Red blood cell count; CRC cis rs1218582 0.741 rs10908446 chr1:154869559 G/A cg06221963 chr1:154839813 KCNN3 -0.77 -15.62 -0.65 1.57e-41 Prostate cancer; CRC cis rs10791323 0.569 rs11533204 chr11:133743644 A/G cg15485101 chr11:133734466 NA 0.43 8.11 0.41 9.96e-15 Childhood ear infection; CRC cis rs13108904 0.935 rs3755920 chr4:1243617 T/C cg15763984 chr4:1342303 KIAA1530 0.34 5.67 0.3 3.2e-8 Obesity-related traits; CRC cis rs898097 0.841 rs2271918 chr17:80861206 A/G cg15664640 chr17:80829946 TBCD -0.73 -11.79 -0.54 5.53e-27 Breast cancer; CRC cis rs13191362 0.872 rs73017702 chr6:163257695 C/A cg21926612 chr6:163149169 PACRG;PARK2 0.7 9.06 0.45 1.15e-17 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs853679 0.517 rs9393891 chr6:28079160 C/T cg12963246 chr6:28129442 ZNF389 0.5 5.8 0.3 1.53e-8 Depression; CRC cis rs1278769 0.786 rs3742238 chr13:113540425 C/T cg00823993 chr13:113535758 ATP11A 0.65 8.63 0.43 2.69e-16 Interstitial lung disease; CRC cis rs929354 0.772 rs1182364 chr7:157017912 T/C cg16102536 chr7:156981717 UBE3C -0.4 -6.73 -0.35 7.4e-11 Body mass index; CRC cis rs208520 1.000 rs72884017 chr6:66992513 T/G cg07460842 chr6:66804631 NA 0.92 11.19 0.53 7.51e-25 Exhaled nitric oxide output; CRC cis rs1448094 0.549 rs4919770 chr12:86238050 G/T cg02569458 chr12:86230093 RASSF9 0.43 7.53 0.38 4.78e-13 Major depressive disorder; CRC cis rs1448094 0.511 rs4897823 chr12:86161484 C/T cg02569458 chr12:86230093 RASSF9 0.42 6.96 0.36 1.89e-11 Major depressive disorder; CRC cis rs2625529 0.652 rs12148078 chr15:72300471 G/C cg16672083 chr15:72433130 SENP8 0.43 6.36 0.33 6.77e-10 Red blood cell count; CRC cis rs6499255 0.951 rs57565297 chr16:69723122 G/T cg04110750 chr16:69646130 NFAT5 -0.58 -7.91 -0.4 3.88e-14 IgE levels; CRC cis rs9457247 1.000 rs10946198 chr6:167404432 C/T cg23791538 chr6:167370224 RNASET2 -0.38 -5.94 -0.31 7.32e-9 Crohn's disease; CRC cis rs7524258 0.867 rs916392 chr1:7271930 T/C cg07173049 chr1:7289937 CAMTA1 0.66 10.33 0.49 7.58e-22 Tourette's syndrome or obsessive-compulsive disorder; CRC cis rs6752107 0.791 rs3792106 chr2:234190740 A/G cg07618928 chr2:234183455 ATG16L1;SCARNA5 0.51 8.06 0.41 1.45e-14 Crohn's disease;Inflammatory bowel disease; CRC cis rs7208859 0.623 rs11658945 chr17:29122509 T/C cg01831904 chr17:28903510 LRRC37B2 -0.63 -6.49 -0.34 3.2e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs7940866 0.745 rs1368853 chr11:130866084 A/G cg12179176 chr11:130786555 SNX19 0.58 8.48 0.42 7.99e-16 Schizophrenia; CRC trans rs7615952 0.512 rs2922175 chr3:125361360 T/C cg02007433 chr3:129722099 NA -0.61 -9.23 -0.45 3.33e-18 Blood pressure (smoking interaction); CRC cis rs17818399 0.620 rs6544906 chr2:46863872 A/C cg26688816 chr2:46740690 ATP6V1E2 -0.41 -5.99 -0.31 5.51e-9 Height; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg03992926 chr1:186344761 TPR;C1orf27;MIR548F1 0.39 6.37 0.33 6.22e-10 Liver disease severity in Alagille syndrome; CRC cis rs7666738 0.861 rs28829607 chr4:98964325 G/C cg17366294 chr4:99064904 C4orf37 0.43 7.36 0.38 1.49e-12 Colonoscopy-negative controls vs population controls; CRC trans rs9956878 0.555 rs8085188 chr18:73544676 A/G cg23226852 chr1:51425652 FAF1 -0.38 -6.21 -0.32 1.56e-9 Obesity-related traits; CRC cis rs2455601 0.766 rs1109304 chr11:8955455 A/G cg21881798 chr11:8931708 C11orf17;ST5 -0.57 -6.52 -0.34 2.65e-10 Schizophrenia; CRC cis rs9549260 0.816 rs9532582 chr13:41251207 A/G cg21288729 chr13:41239152 FOXO1 0.48 7.45 0.38 8.18e-13 Red blood cell count; CRC cis rs6860806 1.000 rs6860806 chr5:131640536 C/T cg18301423 chr5:131593218 PDLIM4 -0.31 -5.9 -0.31 8.8e-9 Breast cancer; CRC cis rs9467711 0.606 rs9393718 chr6:26407482 G/A cg16898833 chr6:26189333 HIST1H4D 0.91 7.38 0.38 1.29e-12 Autism spectrum disorder or schizophrenia; CRC cis rs2742540 0.503 rs11042121 chr11:8932640 A/C cg00186954 chr11:8933980 ST5;C11orf17 0.59 11.09 0.52 1.65e-24 Hematocrit; CRC cis rs56146971 0.763 rs28624795 chr14:91859055 C/T cg16433844 chr14:91963127 SMEK1 -0.59 -6.09 -0.32 3.17e-9 Alzheimer disease and age of onset; CRC cis rs754466 0.580 rs11002294 chr10:79540588 T/C cg26805224 chr10:79626177 DLG5 -0.49 -7.31 -0.37 2.02e-12 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs2425143 1.000 rs2425149 chr20:34359587 G/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.47 -5.88 -0.31 1.01e-8 Blood protein levels; CRC cis rs58688157 0.880 rs12272314 chr11:590648 A/G cg09218773 chr11:619014 MUPCDH -0.4 -6.23 -0.32 1.42e-9 Systemic lupus erythematosus; CRC cis rs35146811 0.735 rs858506 chr7:99820050 T/C cg13334819 chr7:99746414 C7orf59 0.56 7.27 0.37 2.61e-12 Coronary artery disease; CRC cis rs6582630 0.537 rs1949610 chr12:38387838 C/T cg26384229 chr12:38710491 ALG10B 0.69 9.77 0.47 5.95e-20 Drug-induced liver injury (flucloxacillin); CRC cis rs3096299 0.967 rs16965692 chr16:89471482 C/T cg01788221 chr16:89496183 ANKRD11 -0.45 -6.83 -0.35 4.12e-11 Multiple myeloma (IgH translocation); CRC cis rs9786986 0.665 rs12402210 chr1:235701708 T/A cg08848088 chr1:235714526 GNG4 0.57 6.71 0.35 8.3e-11 Body mass index; CRC cis rs10992471 0.630 rs10453241 chr9:95198887 C/A cg14631576 chr9:95140430 CENPP -0.31 -5.93 -0.31 7.52e-9 Visceral adipose tissue/subcutaneous adipose tissue ratio; CRC cis rs4604732 0.631 rs12039642 chr1:247624898 A/G cg02104434 chr1:247694406 LOC148824;OR2C3 0.6 8.82 0.44 6.67e-17 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CRC cis rs4684776 0.676 rs3732941 chr3:11304575 A/G cg00170343 chr3:11313890 ATG7 -0.49 -5.8 -0.3 1.52e-8 Small vessel stroke; CRC cis rs10504229 0.953 rs75545548 chr8:58172816 T/C cg02290350 chr8:58132656 NA -0.42 -5.96 -0.31 6.62e-9 Developmental language disorder (linguistic errors); CRC cis rs2204008 0.806 rs11520229 chr12:38246448 C/A cg26384229 chr12:38710491 ALG10B 0.69 9.22 0.45 3.69e-18 Bladder cancer; CRC cis rs12497850 0.897 rs9884022 chr3:48956862 G/C cg07636037 chr3:49044803 WDR6 1.04 18.48 0.71 8.19e-53 Parkinson's disease; CRC cis rs9534288 0.797 rs9534276 chr13:46574317 T/G cg15192986 chr13:46630673 CPB2 -0.67 -9.85 -0.48 3.16e-20 Blood protein levels; CRC trans rs6550704 0.687 rs9865314 chr3:22634337 A/G cg02757696 chr20:33104113 DYNLRB1 -0.4 -5.98 -0.31 5.82e-9 Daytime sleep phenotypes; CRC cis rs1065852 0.526 rs7290655 chr22:42390225 C/G cg22189786 chr22:42395067 WBP2NL 0.44 6.45 0.34 4.01e-10 Response to serotonin reuptake inhibitors in major depressive disorder (plasma drug and metabolite levels); CRC cis rs7705042 0.861 rs6860138 chr5:141509985 G/A cg07392085 chr5:141489673 NDFIP1 0.46 7.24 0.37 3.17e-12 Asthma; CRC cis rs929596 0.564 rs2741042 chr2:234565917 C/T cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.45 -5.85 -0.31 1.18e-8 Total bilirubin levels in HIV-1 infection; CRC cis rs7208859 0.623 rs28433704 chr17:29084285 G/C cg01831904 chr17:28903510 LRRC37B2 -0.63 -6.53 -0.34 2.51e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC trans rs1455244 0.700 rs7229302 chr18:11508904 G/T cg27388017 chr19:12273827 ZNF136 0.39 6.05 0.32 3.92e-9 Schizophrenia; CRC cis rs1580019 0.961 rs4320456 chr7:32496003 T/C cg06627557 chr7:32535165 LSM5;AVL9 0.71 11.2 0.53 6.71e-25 Cognitive ability; CRC cis rs2120019 0.938 rs2304903 chr15:75315778 A/G cg09165964 chr15:75287851 SCAMP5 -0.86 -13.29 -0.59 1.51e-32 Blood trace element (Zn levels); CRC cis rs2274273 0.837 rs7142857 chr14:55704128 C/T cg23234261 chr14:55582407 NA -0.29 -5.73 -0.3 2.32e-8 Protein biomarker; CRC trans rs6076960 0.684 rs6054058 chr20:6262187 T/C cg24759859 chr6:86352639 SYNCRIP 0.48 6.68 0.35 1.05e-10 Smooth-surface caries; CRC cis rs4713118 0.868 rs2893928 chr6:27738430 C/A cg03623178 chr6:28175578 NA 0.76 8.16 0.41 7.12e-15 Parkinson's disease; CRC cis rs1185460 0.967 rs1784461 chr11:118937985 G/A cg23280166 chr11:118938394 VPS11 0.44 6.71 0.35 8.71e-11 Coronary artery disease; CRC cis rs6723226 0.699 rs805830 chr2:32501475 T/C cg02381751 chr2:32503542 YIPF4 0.54 7.65 0.39 2.2e-13 Intelligence (multi-trait analysis); CRC cis rs7725052 0.609 rs10059585 chr5:40443644 G/A cg09067459 chr5:40385259 NA -0.4 -6.6 -0.34 1.68e-10 Pediatric autoimmune diseases; CRC cis rs752010 0.902 rs60743712 chr1:42076629 G/A cg06885757 chr1:42089581 HIVEP3 0.42 7.5 0.38 5.89e-13 Lupus nephritis in systemic lupus erythematosus; CRC cis rs6933660 0.721 rs2128945 chr6:151767907 A/G cg14262678 chr6:151773367 RMND1;C6orf211 0.56 9.0 0.44 1.9e-17 Menarche (age at onset); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg09431544 chr19:14629187 DNAJB1 0.36 6.34 0.33 7.42e-10 Liver disease severity in Alagille syndrome; CRC cis rs72687362 0.560 rs55878729 chr8:143373005 C/T cg02224795 chr8:143363873 TSNARE1 0.34 5.68 0.3 2.93e-8 Autism spectrum disorder or schizophrenia; CRC trans rs7267979 0.966 rs2261698 chr20:25259910 A/G cg17903999 chr18:56338584 MALT1 -0.42 -6.93 -0.36 2.24e-11 Liver enzyme levels (alkaline phosphatase); CRC cis rs1448094 0.512 rs7970081 chr12:86243392 G/T cg18827107 chr12:86230957 RASSF9 -0.45 -7.42 -0.38 9.97e-13 Major depressive disorder; CRC cis rs11203032 0.831 rs10887928 chr10:90945861 A/T cg16672925 chr10:90967113 CH25H 0.45 5.73 0.3 2.31e-8 Heart failure; CRC cis rs1572438 0.862 rs9378515 chr6:858212 A/G cg13447295 chr6:887704 NA -0.41 -5.9 -0.31 8.87e-9 Aging; CRC trans rs10838798 0.504 rs11039627 chr11:48293931 C/T cg03929089 chr4:120376271 NA -0.46 -6.37 -0.33 6.23e-10 Height; CRC cis rs10504229 0.906 rs7003285 chr8:58173108 A/G cg24829409 chr8:58192753 C8orf71 -0.68 -11.34 -0.53 2.27e-25 Developmental language disorder (linguistic errors); CRC cis rs7731783 1 rs7731783 chr5:177060312 T/C cg10940203 chr5:177434438 FAM153C 0.29 5.84 0.31 1.27e-8 Methadone dose in opioid dependence; CRC cis rs1707322 0.686 rs2275085 chr1:46085852 C/T cg06784218 chr1:46089804 CCDC17 -0.66 -12.33 -0.56 5.49e-29 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs2976388 0.507 rs13259549 chr8:143838519 T/C cg15511327 chr8:143859410 LYNX1 0.5 8.8 0.44 7.76e-17 Urinary tract infection frequency; CRC cis rs1475911 1.000 rs2839467 chr21:43513200 A/G cg19766460 chr21:43528205 UMODL1;C21orf128 -0.66 -7.83 -0.4 6.8e-14 IgG glycosylation; CRC cis rs597539 0.652 rs496616 chr11:68672800 G/C cg06112835 chr11:68658793 MRPL21 0.47 7.59 0.39 3.3e-13 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs4780401 0.609 rs35649585 chr16:11813899 G/A cg01061890 chr16:11836724 TXNDC11 -0.62 -9.28 -0.46 2.37e-18 Rheumatoid arthritis; CRC cis rs10256972 0.577 rs2949179 chr7:1209885 C/G cg07092213 chr7:1199455 ZFAND2A -0.46 -6.77 -0.35 5.8200000000000003e-11 Longevity;Endometriosis; CRC cis rs1707322 0.691 rs12031182 chr1:46220999 C/T cg06784218 chr1:46089804 CCDC17 0.66 12.27 0.56 9.04e-29 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs10782582 0.593 rs17848068 chr1:76190216 G/A cg10523679 chr1:76189770 ACADM -0.41 -5.98 -0.31 5.69e-9 Daytime sleep phenotypes; CRC cis rs950169 0.579 rs62027818 chr15:84661145 T/C cg24253500 chr15:84953950 NA 0.39 6.29 0.33 1.02e-9 Schizophrenia; CRC cis rs754466 0.512 rs67607593 chr10:79649050 A/G cg26805224 chr10:79626177 DLG5 -0.54 -8.02 -0.4 1.91e-14 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs4713118 0.568 rs9468213 chr6:27706180 G/A cg12172441 chr6:28176163 NA 0.46 6.45 0.34 3.93e-10 Parkinson's disease; CRC cis rs9549328 0.800 rs9549616 chr13:113627762 T/G cg24588162 chr13:113633484 MCF2L -0.42 -7.46 -0.38 7.57e-13 Systolic blood pressure; CRC cis rs6540559 0.673 rs41305104 chr1:209950848 G/A cg22029157 chr1:209979665 IRF6 0.66 7.5 0.38 6.14e-13 Cleft lip with or without cleft palate; CRC cis rs10504229 0.679 rs7839948 chr8:58130607 A/G cg05313129 chr8:58192883 C8orf71 -0.43 -6.11 -0.32 2.74e-9 Developmental language disorder (linguistic errors); CRC cis rs3820068 0.581 rs59991988 chr1:15950552 T/A cg24675056 chr1:15929824 NA 0.51 7.04 0.36 1.15e-11 Systolic blood pressure; CRC cis rs11971779 0.680 rs7788777 chr7:139055193 G/C cg07862535 chr7:139043722 LUC7L2 0.58 7.38 0.38 1.28e-12 Diisocyanate-induced asthma; CRC cis rs11212617 0.967 rs9667658 chr11:108276091 C/G cg01991180 chr11:108092276 ATM;NPAT -0.4 -5.66 -0.3 3.38e-8 Response to metformin in type 2 diabetes (glycemic); CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg10668512 chr15:42565522 GANC;TMEM87A 0.5 6.56 0.34 2.1e-10 Thyroid stimulating hormone; CRC cis rs853679 0.517 rs7755442 chr6:28039015 T/C cg15845792 chr6:28175446 NA 0.96 12.86 0.58 6.21e-31 Depression; CRC cis rs877282 0.629 rs78997110 chr10:764388 A/G cg06581033 chr10:766294 NA -0.54 -5.74 -0.3 2.13e-8 Uric acid levels; CRC cis rs2019137 0.936 rs3828189 chr2:113954496 T/A cg21550016 chr2:113992930 PAX8;LOC440839;LOC654433 -0.51 -7.29 -0.37 2.38e-12 Lymphocyte counts; CRC trans rs7267979 0.789 rs4815429 chr20:25521611 T/C cg17903999 chr18:56338584 MALT1 0.4 6.52 0.34 2.71e-10 Liver enzyme levels (alkaline phosphatase); CRC cis rs1552244 0.554 rs59465469 chr3:9990800 G/C cg18598329 chr3:10140678 FANCD2;C3orf24 -0.59 -9.08 -0.45 9.9e-18 Alzheimer's disease; CRC cis rs7333181 1.000 rs1756091 chr13:112219853 A/C cg27543320 chr13:112200689 NA -0.4 -5.7 -0.3 2.68e-8 Menopause (age at onset); CRC cis rs919433 0.963 rs1366837 chr2:198160501 T/C cg20885578 chr2:198174922 NA -0.37 -6.45 -0.34 3.91e-10 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC cis rs4363385 0.693 rs368076 chr1:153046514 A/C cg25856811 chr1:152973957 SPRR3 -0.24 -6.58 -0.34 1.86e-10 Inflammatory skin disease; CRC cis rs1707322 1.000 rs11211239 chr1:46451947 A/G cg03146154 chr1:46216737 IPP 0.51 7.06 0.36 1.01e-11 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs6502050 0.835 rs4789731 chr17:80145904 C/T cg13198984 chr17:80129470 CCDC57 0.46 8.15 0.41 7.94e-15 Life satisfaction; CRC cis rs6712932 1.000 rs1978821 chr2:105833235 C/T cg22878388 chr2:105853796 NA -0.31 -5.99 -0.31 5.56e-9 Type 2 diabetes; CRC cis rs425277 0.585 rs3107157 chr1:2061969 A/G cg19257562 chr1:2043853 PRKCZ 0.39 6.5 0.34 3.01e-10 Height; CRC cis rs950776 0.518 rs4886571 chr15:78833758 G/A cg06917634 chr15:78832804 PSMA4 -0.67 -10.87 -0.51 1.01e-23 Sudden cardiac arrest; CRC cis rs801193 0.548 rs7805152 chr7:66209253 C/T cg11764359 chr7:65958608 NA 0.58 8.73 0.43 1.32e-16 Aortic root size; CRC cis rs2153535 0.541 rs7774752 chr6:8468978 C/T cg21535247 chr6:8435926 SLC35B3 0.5 7.53 0.38 4.89e-13 Motion sickness; CRC cis rs9926296 0.605 rs8046243 chr16:89852133 A/G cg03388025 chr16:89894329 SPIRE2 0.43 8.49 0.42 7.16e-16 Vitiligo; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg16401214 chr16:15982478 C16orf63 0.44 6.08 0.32 3.41e-9 Anxiety disorder; CRC cis rs540254 0.551 rs1961611 chr1:160773029 G/A cg20255094 chr1:160771763 LY9 0.49 6.39 0.33 5.68e-10 Blood protein levels; CRC cis rs10791097 0.694 rs10160281 chr11:130742788 T/C cg12179176 chr11:130786555 SNX19 0.75 12.66 0.57 3.28e-30 Autism spectrum disorder or schizophrenia;Schizophrenia; CRC cis rs2576037 0.526 rs6507714 chr18:44519574 A/G cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.5 7.75 0.39 1.19e-13 Personality dimensions; CRC cis rs6502050 0.871 rs8066970 chr17:80076051 T/C cg19223190 chr17:80058835 NA -0.41 -6.54 -0.34 2.36e-10 Life satisfaction; CRC trans rs1814175 0.645 rs28839231 chr11:50044292 G/T cg15704280 chr7:45808275 SEPT13 -0.93 -17.08 -0.69 2.88e-47 Height; CRC cis rs4843747 0.636 rs11864872 chr16:88105966 A/G cg07865391 chr16:88106882 BANP 0.46 6.04 0.32 4.23e-9 Menopause (age at onset); CRC trans rs6964833 1.000 rs17515241 chr7:74132014 C/T cg07504079 chr7:72649617 NCF1B 0.46 6.11 0.32 2.76e-9 Menarche (age at onset); CRC cis rs459193 1.000 rs30000 chr5:55803533 G/A cg26646659 chr5:55776364 NA 0.49 6.72 0.35 7.87e-11 Coronary artery disease;Type 2 diabetes;Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);Waist-to-hip ratio adjusted for BMI in non-smokers;Waist-to-hip ratio adjusted for BMI (smoking interaction);Waist-to-hip ratio adjusted for body mass index;Waist-hip ratio;Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction); CRC cis rs9560113 1.000 rs11069895 chr13:112178824 C/T cg10483660 chr13:112241077 NA 0.38 5.98 0.31 5.94e-9 Menarche (age at onset); CRC trans rs1005277 0.579 rs2505194 chr10:38393881 C/T cg11292332 chr7:45801988 SEPT13 -0.36 -6.3 -0.33 9.74e-10 Extrinsic epigenetic age acceleration; CRC cis rs13315871 1.000 rs9819072 chr3:58353647 A/C cg20936604 chr3:58311152 NA -0.75 -6.89 -0.35 2.89e-11 Cholesterol, total; CRC cis rs56104184 0.723 rs73063522 chr19:49408358 C/G cg15549821 chr19:49342101 PLEKHA4 -0.51 -5.74 -0.3 2.13e-8 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; CRC cis rs7786808 0.741 rs7789415 chr7:158227617 C/T cg15440763 chr7:158190612 PTPRN2 0.42 6.55 0.34 2.24e-10 Obesity-related traits; CRC cis rs6582630 0.519 rs12366667 chr12:38332632 C/T cg13010199 chr12:38710504 ALG10B 0.46 6.1 0.32 3.04e-9 Drug-induced liver injury (flucloxacillin); CRC cis rs7107174 0.892 rs1017907 chr11:77959124 A/T cg02023728 chr11:77925099 USP35 0.47 7.61 0.39 3e-13 Testicular germ cell tumor; CRC trans rs7267979 0.966 rs2482948 chr20:25296499 T/C cg17903999 chr18:56338584 MALT1 0.43 6.86 0.35 3.43e-11 Liver enzyme levels (alkaline phosphatase); CRC cis rs7527798 0.592 rs11118281 chr1:207832102 C/T cg09232269 chr1:207846808 CR1L -0.51 -8.12 -0.41 9.14e-15 Erythrocyte sedimentation rate; CRC cis rs853679 0.517 rs9393887 chr6:28059020 G/A cg12963246 chr6:28129442 ZNF389 0.48 5.67 0.3 3.1e-8 Depression; CRC cis rs4332037 0.615 rs62435127 chr7:1884937 A/G cg25834613 chr7:1915315 MAD1L1 -0.41 -6.29 -0.33 1e-9 Bipolar disorder; CRC trans rs4689592 0.546 rs10937782 chr4:7057106 G/C cg07817883 chr1:32538562 TMEM39B -0.64 -8.22 -0.41 4.87e-15 Monocyte percentage of white cells; CRC trans rs875971 0.545 rs3735147 chr7:65970528 A/C cg02869306 chr7:64672164 INTS4L1 -0.44 -6.38 -0.33 5.9e-10 Aortic root size; CRC cis rs11148252 0.532 rs9536185 chr13:53179801 G/A cg20354231 chr13:53171401 NA -0.52 -7.95 -0.4 2.95e-14 Lewy body disease; CRC cis rs1572438 0.931 rs9406099 chr6:867030 A/G cg21062780 chr6:887772 NA -0.39 -6.2 -0.32 1.7e-9 Aging; CRC cis rs13082711 0.911 rs6789539 chr3:27444076 T/A cg02860705 chr3:27208620 NA 0.59 8.46 0.42 8.91e-16 Systolic blood pressure;Diastolic blood pressure;Blood pressure; CRC cis rs728616 0.558 rs2343302 chr10:82163186 A/G cg05935833 chr10:81318306 SFTPA2 -0.58 -6.97 -0.36 1.74e-11 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs12477438 0.520 rs36071868 chr2:99737120 G/A cg26064155 chr2:99771622 LIPT1;TSGA10 0.91 16.79 0.68 3.83e-46 Chronic sinus infection; CRC cis rs9325144 0.534 rs4882350 chr12:38686979 A/G cg13010199 chr12:38710504 ALG10B 0.41 6.02 0.32 4.61e-9 Morning vs. evening chronotype; CRC cis rs9611565 0.802 rs9611577 chr22:41793090 T/G cg06634786 chr22:41940651 POLR3H -0.6 -7.1 -0.36 7.75e-12 Vitiligo; CRC cis rs10791097 0.694 rs7942621 chr11:130751308 C/G cg12179176 chr11:130786555 SNX19 0.76 12.62 0.57 4.84e-30 Autism spectrum disorder or schizophrenia;Schizophrenia; CRC cis rs1862618 1.000 rs1862618 chr5:56096315 C/G cg20203395 chr5:56204925 C5orf35 -0.63 -7.67 -0.39 1.94e-13 Initial pursuit acceleration; CRC cis rs10883723 0.810 rs7074343 chr10:104283165 G/A cg04362960 chr10:104952993 NT5C2 -0.42 -5.9 -0.31 8.92e-9 Allergic disease (asthma, hay fever or eczema); CRC cis rs13256369 0.802 rs4840350 chr8:8561442 A/G cg00074818 chr8:8560427 CLDN23 0.41 7.36 0.38 1.45e-12 Obesity-related traits; CRC cis rs10992471 0.729 rs1022844 chr9:95553464 A/T cg13798575 chr9:95087839 CENPP;NOL8 -0.43 -6.07 -0.32 3.59e-9 Visceral adipose tissue/subcutaneous adipose tissue ratio; CRC cis rs4728302 0.869 rs6954712 chr7:133618853 G/A cg03336402 chr7:133662267 EXOC4 -0.44 -6.41 -0.33 4.96e-10 Intelligence;Intelligence (multi-trait analysis); CRC cis rs7089973 0.872 rs35628210 chr10:116630031 G/A cg23260525 chr10:116636907 FAM160B1 0.31 6.77 0.35 5.85e-11 Bipolar disorder or attention deficit hyperactivity disorder; CRC cis rs9858542 0.953 rs6803222 chr3:49665976 T/G cg07274523 chr3:49395745 GPX1 0.47 6.07 0.32 3.48e-9 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs17767294 0.612 rs12332927 chr6:27955115 T/C cg02683197 chr6:28174875 NA 0.65 6.84 0.35 3.95e-11 Parkinson's disease; CRC cis rs9291683 0.588 rs12647117 chr4:10022059 T/C cg00071950 chr4:10020882 SLC2A9 0.67 12.98 0.58 2.23e-31 Bone mineral density; CRC cis rs7131987 0.622 rs7294598 chr12:29531989 A/C cg09582351 chr12:29534625 ERGIC2 0.34 7.47 0.38 7.38e-13 QT interval; CRC cis rs6499255 0.951 rs74026882 chr16:69635059 A/G cg15192750 chr16:69999425 NA 0.56 7.44 0.38 9.02e-13 IgE levels; CRC cis rs853679 0.517 rs4713148 chr6:28115921 G/A cg02683197 chr6:28174875 NA 0.87 10.73 0.51 3.25e-23 Depression; CRC cis rs6502050 0.835 rs66531647 chr17:80089022 G/T cg13198984 chr17:80129470 CCDC57 0.47 8.45 0.42 9.24e-16 Life satisfaction; CRC cis rs28386778 0.897 rs2859619 chr17:61917686 T/C cg06601766 chr17:61851465 DDX42;CCDC47 0.45 6.12 0.32 2.71e-9 Prudent dietary pattern; CRC cis rs7769051 0.522 rs73554461 chr6:133139087 T/G cg22852734 chr6:133119734 C6orf192 0.96 7.47 0.38 7.05e-13 Type 2 diabetes nephropathy; CRC cis rs1760803 0.754 rs3762339 chr1:154208877 A/G cg26808167 chr1:154192205 UBAP2L;C1orf43 -0.34 -5.94 -0.31 7.2e-9 Nicotine dependence; CRC cis rs9303280 0.936 rs12950209 chr17:38049102 T/C cg00129232 chr17:37814104 STARD3 -0.45 -6.95 -0.36 1.92e-11 Self-reported allergy; CRC cis rs2797685 0.945 rs1773138 chr1:7891797 C/T cg04725166 chr1:7887271 PER3 -0.48 -6.06 -0.32 3.69e-9 Crohn's disease; CRC cis rs9916302 0.904 rs9944411 chr17:37483599 T/C cg07936489 chr17:37558343 FBXL20 0.82 12.6 0.57 5.49e-30 Glomerular filtration rate (creatinine); CRC cis rs9926296 0.605 rs12448860 chr16:89849629 T/A cg21285383 chr16:89894308 SPIRE2 0.36 6.12 0.32 2.73e-9 Vitiligo; CRC cis rs12142240 0.730 rs56030283 chr1:46823093 C/G cg00530320 chr1:46809349 NSUN4 0.59 8.03 0.41 1.69e-14 Menopause (age at onset); CRC cis rs9486719 1.000 rs2263192 chr6:96873037 C/G cg06623918 chr6:96969491 KIAA0776 0.81 9.51 0.46 4.17e-19 Migraine;Coronary artery disease; CRC cis rs7727544 0.901 rs55633655 chr5:131598756 T/G cg12564285 chr5:131593104 PDLIM4 0.38 7.39 0.38 1.19e-12 Blood metabolite levels; CRC trans rs2303319 0.582 rs72870248 chr2:162435849 G/A cg14875682 chr5:52083620 ITGA1;PELO -0.75 -6.03 -0.32 4.44e-9 Cognitive function; CRC cis rs2952156 0.876 rs903504 chr17:37829570 C/G cg20243544 chr17:37824526 PNMT 0.57 9.04 0.45 1.33e-17 Asthma; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg08274380 chr1:109419600 GPSM2 0.38 6.11 0.32 2.86e-9 Liver disease severity in Alagille syndrome; CRC cis rs1129187 0.755 rs2274517 chr6:42932715 A/G cg03790207 chr6:42947109 PEX6 0.53 7.82 0.4 7.41e-14 Alzheimer's disease in APOE e4+ carriers; CRC cis rs9322193 0.923 rs9377230 chr6:149934743 T/C cg00933542 chr6:150070202 PCMT1 0.29 6.04 0.32 4.17e-9 Lung cancer; CRC cis rs7945705 0.692 rs11042149 chr11:9010737 T/C cg12365402 chr11:9010492 NRIP3 -0.57 -10.74 -0.51 2.88e-23 Hemoglobin concentration; CRC cis rs3858526 0.959 rs10838795 chr11:5920721 A/G cg02574844 chr11:5959923 NA 0.4 5.72 0.3 2.4e-8 DNA methylation (variation); CRC cis rs60871478 0.730 rs62432226 chr7:792973 T/C cg13844804 chr7:814759 HEATR2 0.68 7.94 0.4 3.3e-14 Cerebrospinal P-tau181p levels; CRC cis rs10746514 0.931 rs11582890 chr1:232251218 C/T cg09506761 chr1:232265262 NA 0.43 5.63 0.3 3.79e-8 Response to statin therapy; CRC cis rs11583043 1.000 rs12567858 chr1:101517688 A/G cg16556008 chr1:101360663 SLC30A7;EXTL2 0.47 5.87 0.31 1.06e-8 Ulcerative colitis;Inflammatory bowel disease; CRC cis rs7264396 0.573 rs58355182 chr20:34075687 T/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.39 -6.53 -0.34 2.44e-10 Total cholesterol levels; CRC cis rs853679 0.517 rs6922063 chr6:28094366 G/A cg18032046 chr6:28092343 ZSCAN16 -0.5 -5.89 -0.31 9.29e-9 Depression; CRC cis rs9914988 0.887 rs12948575 chr17:27130520 G/A cg20469991 chr17:27169893 C17orf63 -0.6 -7.27 -0.37 2.59e-12 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs644799 1.000 rs623191 chr11:95548359 A/G cg25478527 chr11:95522999 CEP57;FAM76B 0.51 7.69 0.39 1.68e-13 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC trans rs877282 0.898 rs12356709 chr10:763365 A/G cg22713356 chr15:30763199 NA 1.28 15.26 0.64 3.9e-40 Uric acid levels; CRC cis rs360798 0.512 rs2710640 chr2:63144305 A/G cg17519650 chr2:63277830 OTX1 0.44 6.33 0.33 7.97e-10 Coronary artery disease; CRC cis rs7786808 0.615 rs4909209 chr7:158194329 C/T cg17401720 chr7:158221031 PTPRN2 0.39 6.05 0.32 3.9e-9 Obesity-related traits; CRC cis rs4721295 0.573 rs3779000 chr7:2181628 G/A cg21782813 chr7:2030301 MAD1L1 0.5 8.42 0.42 1.16e-15 Schizophrenia, schizoaffective disorder or bipolar disorder; CRC cis rs7224685 0.501 rs11649992 chr17:4026823 A/C cg11204139 chr17:3907470 NA -0.76 -13.54 -0.6 1.71e-33 Type 2 diabetes; CRC trans rs7937682 0.924 rs1784782 chr11:111525764 A/C cg18187862 chr3:45730750 SACM1L 0.48 6.88 0.35 3.04e-11 Primary sclerosing cholangitis; CRC trans rs2797160 0.967 rs28629380 chr6:126004197 A/G cg05039488 chr6:79577232 IRAK1BP1 -0.5 -7.21 -0.37 3.81e-12 Endometrial cancer; CRC cis rs4803468 1.000 rs284656 chr19:41929251 T/C cg09537434 chr19:41945824 ATP5SL -0.97 -18.39 -0.71 1.96e-52 Height; CRC cis rs1577917 1.000 rs12205336 chr6:86722367 A/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.52 -6.53 -0.34 2.57e-10 Response to antipsychotic treatment; CRC trans rs1656966 1.000 rs1656966 chr3:186466252 C/T cg01338834 chr21:40720919 HMGN1 0.44 6.55 0.34 2.28e-10 Myopia (pathological); CRC cis rs11608355 0.508 rs2075434 chr12:109797051 G/A cg19025524 chr12:109796872 NA -0.51 -7.63 -0.39 2.56e-13 Neuroticism; CRC cis rs4819052 0.851 rs2838865 chr21:46712299 C/T cg19498844 chr21:46707878 POFUT2;LOC642852 0.8 11.78 0.54 5.78e-27 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs853679 0.517 rs3734573 chr6:28059437 T/C cg25164649 chr6:28176230 NA 0.75 9.36 0.46 1.32e-18 Depression; CRC cis rs394563 0.591 rs237029 chr6:149717425 A/G cg16235748 chr6:149772707 ZC3H12D -0.37 -6.78 -0.35 5.58e-11 Dupuytren's disease; CRC cis rs28386778 0.897 rs8067102 chr17:61848779 C/G cg22520471 chr17:61851767 DDX42;CCDC47 0.74 11.57 0.54 3.22e-26 Prudent dietary pattern; CRC cis rs738321 0.757 rs3788534 chr22:38533971 A/T cg25457927 chr22:38595422 NA -0.29 -5.72 -0.3 2.45e-8 Breast cancer; CRC trans rs16846053 0.579 rs57887363 chr2:162588720 C/T cg14875682 chr5:52083620 ITGA1;PELO -0.75 -6.06 -0.32 3.67e-9 Blood osmolality (transformed sodium); CRC cis rs7493 0.853 rs6973380 chr7:95043523 C/T cg07404485 chr7:94953653 PON1 -0.45 -6.14 -0.32 2.44e-9 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs12044355 0.927 rs16854809 chr1:231839247 A/G cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX 0.44 5.94 0.31 7.06e-9 Alzheimer's disease; CRC cis rs889312 0.500 rs832552 chr5:56113850 A/C cg12311346 chr5:56204834 C5orf35 0.45 6.99 0.36 1.5e-11 Breast cancer;Breast cancer (early onset); CRC cis rs4604732 0.631 rs11490200 chr1:247625915 G/T cg12754571 chr1:247694271 LOC148824;OR2C3 0.41 5.78 0.3 1.74e-8 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CRC cis rs6834538 0.539 rs10434013 chr4:113401356 T/G cg10021238 chr4:113569128 MIR367;LARP7 -0.39 -5.75 -0.3 2.02e-8 Free thyroxine concentration; CRC cis rs2836974 0.831 rs2836921 chr21:40516070 C/T cg17971929 chr21:40555470 PSMG1 0.71 9.64 0.47 1.6e-19 Cognitive function; CRC cis rs9372498 0.505 rs9481789 chr6:118734320 A/C cg07617317 chr6:118971624 C6orf204 0.52 6.48 0.34 3.43e-10 Diastolic blood pressure; CRC cis rs733592 0.507 rs10875739 chr12:48480919 C/T cg24011408 chr12:48396354 COL2A1 0.41 5.88 0.31 9.96e-9 Plateletcrit; CRC cis rs9905704 0.918 rs4132924 chr17:56937653 C/T cg12560992 chr17:57184187 TRIM37 0.53 7.36 0.38 1.47e-12 Testicular germ cell tumor; CRC cis rs12760731 0.668 rs72482621 chr1:178410442 C/T cg00404053 chr1:178313656 RASAL2 0.96 9.87 0.48 2.62e-20 Obesity-related traits; CRC cis rs9322193 0.923 rs9285524 chr6:150015258 G/A cg05861140 chr6:150128134 PCMT1 -0.42 -6.87 -0.35 3.13e-11 Lung cancer; CRC cis rs2576037 0.558 rs7244778 chr18:44541915 T/C cg24750912 chr18:44543259 TCEB3CL;KATNAL2 0.32 6.35 0.33 7.15e-10 Personality dimensions; CRC trans rs8005150 0.737 rs7156254 chr14:88481294 G/A cg25527770 chr19:1444892 NA -0.58 -6.24 -0.33 1.32e-9 Hepatitis B; CRC cis rs6424115 0.862 rs34845821 chr1:24066486 C/T cg10978503 chr1:24200527 CNR2 -0.43 -6.28 -0.33 1.06e-9 Immature fraction of reticulocytes; CRC cis rs2274471 0.645 rs2031907 chr9:5087596 G/A cg03390472 chr9:5043263 JAK2 -0.56 -6.01 -0.31 4.92e-9 Crohn's disease; CRC cis rs3540 0.574 rs8035980 chr15:90974390 C/G cg22089800 chr15:90895588 ZNF774 0.57 9.65 0.47 1.48e-19 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; CRC cis rs2797160 1.000 rs1777226 chr6:126017691 C/A cg05901451 chr6:126070800 HEY2 0.4 6.05 0.32 3.83e-9 Endometrial cancer; CRC cis rs926938 0.618 rs904292 chr1:115358421 C/T cg12756093 chr1:115239321 AMPD1 0.59 8.63 0.43 2.75e-16 Autism; CRC trans rs9341835 0.679 rs9344137 chr6:64156964 A/T cg13657004 chr13:50234944 EBPL -0.38 -6.27 -0.33 1.15e-9 Schizophrenia; CRC cis rs2075371 0.796 rs12672752 chr7:134007382 C/T cg20476274 chr7:133979776 SLC35B4 0.67 11.07 0.52 1.99e-24 Mean platelet volume; CRC cis rs1005277 0.579 rs2474572 chr10:38385316 A/G cg25517755 chr10:38738941 LOC399744 -0.41 -6.09 -0.32 3.13e-9 Extrinsic epigenetic age acceleration; CRC cis rs853679 0.546 rs200981 chr6:27833174 A/G cg15845792 chr6:28175446 NA 0.71 6.22 0.32 1.51e-9 Depression; CRC cis rs2019137 0.868 rs6755639 chr2:113981810 A/G cg19083407 chr2:113993142 PAX8;LOC440839;LOC654433 0.46 6.48 0.34 3.27e-10 Lymphocyte counts; CRC cis rs9549328 0.616 rs35086993 chr13:113617305 G/A cg08614441 chr13:113633676 MCF2L 0.4 7.08 0.36 8.76e-12 Systolic blood pressure; CRC cis rs2239547 0.562 rs35380116 chr3:52979178 A/G cg15147215 chr3:52552868 STAB1 0.38 5.77 0.3 1.81e-8 Schizophrenia; CRC cis rs2032447 0.613 rs6456708 chr6:26032847 G/C cg18357526 chr6:26021779 HIST1H4A 0.43 6.3 0.33 9.59e-10 Intelligence (multi-trait analysis); CRC cis rs798554 0.660 rs2283783 chr7:2855326 G/A cg17321639 chr7:2759063 NA -0.42 -6.27 -0.33 1.11e-9 Height; CRC cis rs9399135 0.967 rs4895439 chr6:135318854 A/T cg22676075 chr6:135203613 NA 0.41 6.38 0.33 6.03e-10 Red blood cell count; CRC cis rs2075371 1.000 rs7486 chr7:133975183 A/G cg11752832 chr7:134001865 SLC35B4 0.48 7.47 0.38 7.24e-13 Mean platelet volume; CRC cis rs6840360 0.593 rs867800 chr4:152691470 T/C cg09659197 chr4:152720779 NA 0.41 8.44 0.42 1.06e-15 Intelligence (multi-trait analysis); CRC cis rs12791968 0.765 rs2279359 chr11:44999605 A/G cg11846598 chr11:44996168 LOC221122 0.57 8.27 0.41 3.44e-15 Inhibitory control; CRC cis rs1559088 0.573 rs1270591 chr19:33622942 C/T cg17764715 chr19:33622953 WDR88 -0.47 -6.99 -0.36 1.57e-11 Bone ultrasound measurement (broadband ultrasound attenuation); CRC cis rs3889199 0.924 rs12569192 chr1:59676567 G/A cg25881383 chr1:59680599 NA -0.38 -6.05 -0.32 3.94e-9 Pulse pressure; CRC cis rs801193 1.000 rs2659889 chr7:66217112 A/G cg00343986 chr7:65444356 GUSB 0.49 7.32 0.37 1.92e-12 Aortic root size; CRC cis rs9427116 0.502 rs9426829 chr1:154592201 T/C cg17218026 chr1:154582156 ADAR 0.67 11.63 0.54 2.04e-26 Blood protein levels; CRC cis rs270601 0.770 rs4361510 chr5:131599647 C/T cg20512303 chr5:131592959 PDLIM4 0.4 7.58 0.39 3.67e-13 Acylcarnitine levels; CRC trans rs6703335 0.870 rs10803142 chr1:243598234 A/G cg00528793 chr22:19842837 GNB1L;C22orf29 0.44 5.98 0.31 5.92e-9 Schizophrenia;Schizophrenia, schizoaffective disorder or bipolar disorder; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg01363902 chr12:121022439 NA 0.43 6.22 0.32 1.51e-9 Response to antipsychotic treatment; CRC cis rs9814567 1.000 rs17694011 chr3:134213981 T/C cg06109529 chr3:134205091 CEP63;ANAPC13 -0.81 -12.26 -0.56 1e-28 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs2721195 0.967 rs10108150 chr8:145687475 A/G cg26752003 chr8:145688521 CYHR1 0.61 10.17 0.49 2.55e-21 Age at first birth; CRC trans rs9291683 0.588 rs4697705 chr4:10108127 G/A cg26043149 chr18:55253948 FECH -0.5 -7.56 -0.38 3.97e-13 Bone mineral density; CRC trans rs12940923 1.000 rs11658637 chr17:56376508 A/G cg16900910 chr15:72789182 ARIH1 0.53 6.04 0.32 4.09e-9 Circulating myeloperoxidase levels (plasma); CRC cis rs12347191 0.500 rs907582 chr9:100621926 T/C cg13688889 chr9:100608707 NA -0.47 -5.98 -0.31 5.87e-9 Orofacial clefts; CRC cis rs881375 0.934 rs2159778 chr9:123678129 G/A cg14255062 chr9:123606675 PSMD5;LOC253039 0.42 6.36 0.33 6.57e-10 Rheumatoid arthritis; CRC cis rs909002 0.800 rs10914459 chr1:32096918 T/C cg13919466 chr1:32135498 COL16A1 -0.31 -5.82 -0.31 1.42e-8 Intelligence (multi-trait analysis); CRC cis rs2739330 0.760 rs5751760 chr22:24243573 G/A cg18538332 chr22:24372958 LOC391322 -0.68 -10.46 -0.5 2.75e-22 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs11212617 0.967 rs4987982 chr11:108151269 G/A cg01991180 chr11:108092276 ATM;NPAT 0.43 6.24 0.33 1.38e-9 Response to metformin in type 2 diabetes (glycemic); CRC cis rs11583043 0.575 rs56403901 chr1:101586047 A/T cg16556008 chr1:101360663 SLC30A7;EXTL2 0.46 5.94 0.31 7.06e-9 Ulcerative colitis;Inflammatory bowel disease; CRC cis rs8180040 1.000 rs7613282 chr3:47389409 C/T cg02527881 chr3:46936655 PTH1R 0.38 6.98 0.36 1.63e-11 Colorectal cancer; CRC cis rs7215564 0.908 rs34267318 chr17:78664619 G/A cg09596252 chr17:78655493 RPTOR 0.56 6.11 0.32 2.76e-9 Myopia (pathological); CRC cis rs9868809 0.505 rs11719291 chr3:48735706 A/G cg07636037 chr3:49044803 WDR6 -0.68 -6.79 -0.35 5.19e-11 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; CRC cis rs6988636 1.000 rs10096350 chr8:124184470 T/C cg27053337 chr8:124217698 FAM83A 0.45 6.81 0.35 4.55e-11 Urinary uromodulin levels; CRC cis rs10208940 0.619 rs34187568 chr2:68863493 C/T cg12452813 chr2:68675892 NA 0.52 6.34 0.33 7.55e-10 Urate levels in lean individuals; CRC cis rs9733 0.596 rs12072339 chr1:150686099 A/G cg18016565 chr1:150552671 MCL1 0.45 6.52 0.34 2.57e-10 Tonsillectomy; CRC cis rs11229555 1.000 rs12787765 chr11:58400686 G/A cg15696309 chr11:58395628 NA -0.95 -13.52 -0.6 1.94e-33 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; CRC cis rs4692589 0.581 rs62344678 chr4:170961308 G/A cg19918862 chr4:170955249 NA 0.53 6.98 0.36 1.66e-11 Anxiety disorder; CRC cis rs6496667 0.779 rs2283443 chr15:91001300 C/G cg04176472 chr15:90893244 GABARAPL3 0.58 8.33 0.42 2.29e-15 Rheumatoid arthritis; CRC cis rs459193 1.000 rs30000 chr5:55803533 G/A cg18302225 chr5:55776401 NA 0.59 8.67 0.43 1.98e-16 Coronary artery disease;Type 2 diabetes;Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);Waist-to-hip ratio adjusted for BMI in non-smokers;Waist-to-hip ratio adjusted for BMI (smoking interaction);Waist-to-hip ratio adjusted for body mass index;Waist-hip ratio;Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction); CRC cis rs1707322 0.752 rs28550303 chr1:46188914 G/T cg06784218 chr1:46089804 CCDC17 0.65 12.02 0.55 7.5e-28 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs826838 1.000 rs34254519 chr12:39041235 G/A cg13010199 chr12:38710504 ALG10B 0.44 5.82 0.31 1.36e-8 Heart rate; CRC cis rs6963495 0.818 rs117907809 chr7:105168472 C/A cg02135003 chr7:105160482 PUS7 -0.92 -12.45 -0.57 2.03e-29 Bipolar disorder (body mass index interaction); CRC cis rs6500602 0.647 rs4786519 chr16:4584406 C/T cg08645402 chr16:4508243 NA 0.63 11.13 0.52 1.21e-24 Schizophrenia; CRC cis rs10540 0.908 rs71487293 chr11:486414 G/A cg03576123 chr11:487126 PTDSS2 -1.03 -10.3 -0.49 9.36e-22 Body mass index; CRC cis rs41271473 0.526 rs10916343 chr1:228727961 C/T cg16512390 chr1:228756714 NA 0.64 6.72 0.35 7.95e-11 Chronic lymphocytic leukemia; CRC cis rs9372498 0.536 rs72969531 chr6:118729974 C/A cg07617317 chr6:118971624 C6orf204 0.52 6.52 0.34 2.68e-10 Diastolic blood pressure; CRC cis rs875971 1.000 rs1183245 chr7:65541185 C/T cg18876405 chr7:65276391 NA -0.52 -8.8 -0.44 7.65e-17 Aortic root size; CRC cis rs7666738 0.830 rs13328005 chr4:99055480 T/C cg05340658 chr4:99064831 C4orf37 0.58 8.85 0.44 5.63e-17 Colonoscopy-negative controls vs population controls; CRC cis rs2635047 0.875 rs2251948 chr18:44681356 A/T cg19077165 chr18:44547161 KATNAL2 -0.45 -7.48 -0.38 7.03e-13 Educational attainment; CRC cis rs1707322 0.717 rs1135850 chr1:46093692 G/A cg03146154 chr1:46216737 IPP 0.66 9.35 0.46 1.44e-18 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs7937682 0.889 rs1784785 chr11:111483306 A/G cg09085632 chr11:111637200 PPP2R1B -0.98 -19.21 -0.73 1.09e-55 Primary sclerosing cholangitis; CRC cis rs7618915 0.547 rs11130315 chr3:52697163 A/G cg11645453 chr3:52864694 ITIH4 0.35 6.14 0.32 2.31e-9 Bipolar disorder; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg27109030 chr19:2702898 GNG7 -0.37 -6.06 -0.32 3.65e-9 Myopia (pathological); CRC cis rs4654899 0.758 rs12137408 chr1:21282945 A/G cg02927042 chr1:21476669 EIF4G3 -0.39 -6.26 -0.33 1.17e-9 Superior frontal gyrus grey matter volume; CRC trans rs7395662 0.963 rs4882112 chr11:48561083 G/C cg21153622 chr11:89784906 NA -0.44 -7.11 -0.36 7.07e-12 HDL cholesterol; CRC cis rs10504229 1.000 rs67237174 chr8:58175776 T/C cg02290350 chr8:58132656 NA -0.42 -5.93 -0.31 7.47e-9 Developmental language disorder (linguistic errors); CRC cis rs7811142 0.562 rs7786844 chr7:99934008 T/G cg00814883 chr7:100076585 TSC22D4 -0.65 -8.26 -0.41 3.52e-15 Platelet count; CRC cis rs4665809 0.590 rs2384361 chr2:26452209 T/C cg26119090 chr2:26468346 HADHA;HADHB -1.05 -15.29 -0.64 3.13e-40 Gut microbiome composition (summer); CRC trans rs9561329 0.800 rs9524036 chr13:94037300 T/A cg23072629 chr2:239195537 PER2 0.33 6.26 0.33 1.2e-9 Neuroticism (age interaction); CRC cis rs1005277 0.579 rs1740749 chr10:38521646 A/G cg25517755 chr10:38738941 LOC399744 -0.41 -5.92 -0.31 8.23e-9 Extrinsic epigenetic age acceleration; CRC cis rs62064224 0.905 rs9891969 chr17:30627085 C/T cg09324608 chr17:30823087 MYO1D 0.39 6.55 0.34 2.22e-10 Schizophrenia; CRC cis rs7894407 0.760 rs1163085 chr10:105039241 G/A cg05636881 chr10:105038444 INA 0.37 5.97 0.31 6.15e-9 White matter hyperintensity burden; CRC cis rs3733585 0.648 rs13125029 chr4:9982029 A/G cg00071950 chr4:10020882 SLC2A9 0.55 9.77 0.47 5.7e-20 Cleft plate (environmental tobacco smoke interaction); CRC cis rs6546324 0.625 rs2861640 chr2:67794589 G/C cg15745817 chr2:67799979 NA -0.54 -9.09 -0.45 9.4e-18 Endometriosis; CRC cis rs7739232 0.920 rs77164467 chr6:53529687 G/C cg15658676 chr6:53530538 KLHL31 -0.76 -5.9 -0.31 8.9e-9 Hip circumference adjusted for BMI; CRC cis rs7246967 0.673 rs35061555 chr19:22963766 T/C cg08271804 chr19:22816896 ZNF492 0.38 5.85 0.31 1.2e-8 Bronchopulmonary dysplasia; CRC cis rs4253772 0.513 rs9306512 chr22:46716603 T/C cg24881330 chr22:46731750 TRMU 0.7 8.57 0.43 3.99e-16 LDL cholesterol;Cholesterol, total; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg14546197 chr17:38137043 PSMD3 0.4 6.35 0.33 7.1e-10 Liver disease severity in Alagille syndrome; CRC trans rs9858542 0.953 rs11715915 chr3:49455330 A/G cg21665057 chr3:196295764 WDR53;FBXO45 0.57 7.62 0.39 2.73e-13 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs4689388 0.890 rs1801206 chr4:6302707 C/T cg25554036 chr4:6271136 WFS1 0.54 8.68 0.43 1.89e-16 Type 2 diabetes and other traits;Type 2 diabetes; CRC cis rs597539 0.652 rs553875 chr11:68695144 T/G cg06028808 chr11:68637592 NA 0.37 5.68 0.3 2.9e-8 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC trans rs10050311 0.698 rs3775238 chr4:87633384 G/A cg00004207 chr2:38977301 SFRS7 0.53 6.47 0.34 3.6e-10 Insulin-related traits; CRC cis rs7945705 0.869 rs11042154 chr11:9029700 A/G cg14711859 chr11:8959438 ASCL3 0.43 6.83 0.35 4.16e-11 Hemoglobin concentration; CRC trans rs61931739 0.534 rs11053005 chr12:34091626 A/C cg26384229 chr12:38710491 ALG10B 0.54 6.99 0.36 1.5e-11 Morning vs. evening chronotype; CRC cis rs873946 0.586 rs12770021 chr10:134562021 G/A cg06453172 chr10:134556979 INPP5A -0.66 -7.88 -0.4 4.76e-14 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CRC cis rs7677751 0.806 rs890203 chr4:55097405 A/C cg13615338 chr4:55094005 PDGFRA 0.4 5.8 0.3 1.57e-8 Corneal astigmatism; CRC cis rs9916302 0.904 rs2024073 chr17:37471330 T/G cg15445000 chr17:37608096 MED1 -0.42 -9.02 -0.45 1.56e-17 Glomerular filtration rate (creatinine); CRC cis rs4891159 0.790 rs17059379 chr18:74160316 A/T cg24786174 chr18:74118243 ZNF516 0.77 13.12 0.59 6.18e-32 Longevity; CRC cis rs929354 0.772 rs2366214 chr7:156992461 A/G cg16102536 chr7:156981717 UBE3C 0.4 6.76 0.35 6.39e-11 Body mass index; CRC cis rs12802200 0.535 rs12282299 chr11:570009 T/C cg09218773 chr11:619014 MUPCDH -0.36 -5.71 -0.3 2.56e-8 Systemic lupus erythematosus; CRC cis rs7726839 0.794 rs10474792 chr5:600058 G/A cg14541582 chr5:601475 NA -0.25 -5.65 -0.3 3.48e-8 Obesity-related traits; CRC cis rs3741404 0.825 rs11604782 chr11:63946650 G/A cg05016508 chr11:63871570 FLRT1;MACROD1 0.47 6.99 0.36 1.51e-11 Platelet count; CRC cis rs7552404 0.824 rs1251079 chr1:76189445 C/T cg03433033 chr1:76189801 ACADM 0.93 17.33 0.69 2.93e-48 Blood metabolite levels;Acylcarnitine levels; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg15761814 chr2:109403565 CCDC138 0.49 7.02 0.36 1.3e-11 Response to antipsychotic treatment; CRC cis rs8067545 0.750 rs7208635 chr17:19990990 T/C cg13482628 chr17:19912719 NA 0.5 7.85 0.4 5.97e-14 Schizophrenia; CRC cis rs9611565 0.729 rs4822027 chr22:41786227 G/A cg03806693 chr22:41940476 POLR3H -1.07 -13.42 -0.59 4.59e-33 Vitiligo; CRC cis rs6665290 0.904 rs1045285 chr1:227179054 G/A cg10327440 chr1:227177885 CDC42BPA -1.03 -22.9 -0.78 4.58e-70 Myeloid white cell count; CRC cis rs9916302 0.851 rs4794810 chr17:37603774 T/C cg00129232 chr17:37814104 STARD3 -0.56 -8.24 -0.41 4.25e-15 Glomerular filtration rate (creatinine); CRC cis rs2204008 0.550 rs11495600 chr12:38126654 C/T cg13010199 chr12:38710504 ALG10B 0.45 5.74 0.3 2.1e-8 Bladder cancer; CRC cis rs3820068 0.581 rs72645871 chr1:15926142 G/A cg24675056 chr1:15929824 NA 0.49 6.66 0.34 1.12e-10 Systolic blood pressure; CRC cis rs6951245 0.872 rs75280240 chr7:1058511 C/T cg04025307 chr7:1156635 C7orf50 0.66 7.04 0.36 1.11e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs9322193 0.923 rs9766004 chr6:150075499 C/T cg00933542 chr6:150070202 PCMT1 0.3 6.32 0.33 8.68e-10 Lung cancer; CRC cis rs10256972 0.786 rs3735686 chr7:1062527 G/A cg03188948 chr7:1209495 NA 0.41 5.87 0.31 1.08e-8 Longevity;Endometriosis; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg15400169 chr12:120639619 RPLP0 0.39 6.11 0.32 2.84e-9 Liver disease severity in Alagille syndrome; CRC cis rs2242116 0.727 rs4683298 chr3:46966387 C/G cg02527881 chr3:46936655 PTH1R -0.48 -8.66 -0.43 2.15e-16 Birth weight; CRC cis rs1552244 0.882 rs13099507 chr3:10031603 G/A cg00166722 chr3:10149974 C3orf24 0.62 7.61 0.39 2.98e-13 Alzheimer's disease; CRC cis rs16867335 1.000 rs6739798 chr2:181465853 T/C cg23363182 chr2:181467187 NA -0.49 -6.62 -0.34 1.45e-10 Survival in rectal cancer; CRC cis rs6815814 0.950 rs5743560 chr4:38806200 G/T cg06935464 chr4:38784597 TLR10 0.57 5.97 0.31 6.19e-9 Breast cancer; CRC cis rs243505 0.691 rs243486 chr7:148448221 A/C cg09806900 chr7:148480153 CUL1 -0.59 -7.5 -0.38 5.93e-13 Inflammatory bowel disease;Crohn's disease; CRC cis rs1046896 0.594 rs4075209 chr17:80800027 G/T cg19046167 chr17:80928561 B3GNTL1 0.51 7.07 0.36 9.59e-12 Glycated hemoglobin levels; CRC cis rs1862618 0.641 rs252893 chr5:56224714 T/C cg03609598 chr5:56110824 MAP3K1 -0.58 -7.78 -0.39 9.57e-14 Initial pursuit acceleration; CRC cis rs3087591 1.000 rs12600974 chr17:29589360 A/G cg24425628 chr17:29625626 OMG;NF1 0.88 16.93 0.68 1.06e-46 Hip circumference; CRC cis rs6088590 1.000 rs6058111 chr20:33310999 T/C cg08999081 chr20:33150536 PIGU 0.49 8.44 0.42 1e-15 Coronary artery disease; CRC cis rs875971 0.862 rs6460290 chr7:65809106 G/A cg18876405 chr7:65276391 NA -0.52 -8.6 -0.43 3.21e-16 Aortic root size; CRC cis rs9486719 0.947 rs72932805 chr6:96902933 T/G cg06623918 chr6:96969491 KIAA0776 -0.8 -9.2 -0.45 4.3e-18 Migraine;Coronary artery disease; CRC cis rs875971 0.767 rs1643394 chr7:65836094 A/G cg00343986 chr7:65444356 GUSB 0.42 5.93 0.31 7.86e-9 Aortic root size; CRC cis rs736408 0.924 rs2535629 chr3:52833219 C/T cg11645453 chr3:52864694 ITIH4 0.45 8.13 0.41 9.1e-15 Bipolar disorder; CRC cis rs12188164 0.543 rs2672722 chr5:453567 G/A cg14122633 chr5:456516 EXOC3 -0.4 -7.11 -0.36 7.32e-12 Cystic fibrosis severity; CRC cis rs477895 0.653 rs72918475 chr11:63878644 G/C cg05016508 chr11:63871570 FLRT1;MACROD1 0.53 6.55 0.34 2.17e-10 Mean platelet volume; CRC cis rs9368481 0.646 rs75843621 chr6:26967881 G/A cg18278486 chr6:26987575 LOC100270746;C6orf41 -0.48 -7.59 -0.39 3.23e-13 Autism spectrum disorder or schizophrenia; CRC cis rs1564271 0.553 rs9334138 chr10:26978929 G/A cg13837822 chr10:26931731 LOC731789 0.58 8.96 0.44 2.51e-17 Overall survival in serous epithelial ovarian cancer treated with paclitaxel and cisplatin; CRC trans rs561341 0.663 rs72821936 chr17:30224068 C/G cg20587970 chr11:113659929 NA -0.55 -7.46 -0.38 7.91e-13 Hip circumference adjusted for BMI; CRC cis rs9325144 0.560 rs7980635 chr12:38668355 G/T cg13010199 chr12:38710504 ALG10B -0.42 -6.17 -0.32 2.06e-9 Morning vs. evening chronotype; CRC trans rs208520 0.821 rs9363572 chr6:67012231 C/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.83 9.86 0.48 2.82e-20 Exhaled nitric oxide output; CRC cis rs2228479 0.850 rs3785281 chr16:89824263 G/C cg06656553 chr16:89960601 TCF25 -0.7 -5.76 -0.3 1.93e-8 Skin colour saturation; CRC cis rs6952808 0.582 rs10479762 chr7:2045351 T/C cg02951883 chr7:2050386 MAD1L1 0.64 10.57 0.5 1.09e-22 Bipolar disorder and schizophrenia; CRC cis rs826838 0.586 rs10880753 chr12:38628147 C/A cg26384229 chr12:38710491 ALG10B -0.53 -7.63 -0.39 2.48e-13 Heart rate; CRC cis rs6764363 0.504 rs13077665 chr3:277878 C/G cg02057681 chr3:285234 CHL1 0.42 7.14 0.37 5.94e-12 Sudden cardiac arrest; CRC cis rs9325144 0.647 rs12831609 chr12:39051576 C/A cg26384229 chr12:38710491 ALG10B -0.53 -7.46 -0.38 7.59e-13 Morning vs. evening chronotype; CRC trans rs7873102 0.702 rs7028020 chr9:38007747 C/T cg12032191 chr1:46152434 TMEM69;GPBP1L1 -0.42 -6.02 -0.31 4.63e-9 Brain structure; CRC cis rs7408868 1.000 rs4809030 chr19:15273381 A/G cg14696996 chr19:15285081 NOTCH3 0.97 8.99 0.44 1.99e-17 Pulse pressure; CRC cis rs7044106 0.791 rs10760116 chr9:123494681 C/T cg09419670 chr9:123605666 PSMD5;LOC253039 0.78 12.97 0.58 2.27e-31 Hip circumference adjusted for BMI; CRC cis rs1163251 0.902 rs511059 chr1:120217081 G/T cg19096424 chr1:120255104 PHGDH 0.46 6.65 0.34 1.26e-10 Blood metabolite levels; CRC cis rs7216064 1.000 rs55939964 chr17:65869297 G/A cg12091567 chr17:66097778 LOC651250 -0.67 -7.79 -0.39 8.84e-14 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CRC trans rs459571 0.959 rs460888 chr9:136913123 C/G cg15028160 chr19:49622717 PPFIA3;C19orf73 -0.54 -6.73 -0.35 7.59e-11 Platelet distribution width; CRC cis rs782590 0.902 rs782601 chr2:55848244 T/C cg18811423 chr2:55921094 PNPT1 0.79 14.08 0.61 1.43e-35 Metabolic syndrome; CRC cis rs7927771 0.725 rs11570094 chr11:47359706 A/C cg20307385 chr11:47447363 PSMC3 0.44 5.67 0.3 3.1e-8 Subjective well-being; CRC cis rs6700896 0.864 rs6588153 chr1:66092017 T/A cg04111102 chr1:66153794 NA 0.33 5.8 0.3 1.55e-8 C-reactive protein;Mean corpuscular volume;Mean corpuscular hemoglobin; CRC cis rs7666738 0.830 rs9995370 chr4:98732145 T/G cg05340658 chr4:99064831 C4orf37 0.54 8.0 0.4 2.21e-14 Colonoscopy-negative controls vs population controls; CRC cis rs2032447 0.798 rs807214 chr6:26061769 G/C cg03264133 chr6:25882463 NA -0.47 -6.44 -0.33 4.21e-10 Intelligence (multi-trait analysis); CRC cis rs11669181 1 rs11669181 chr19:14445138 A/G cg25450033 chr19:14444658 NA -0.37 -6.75 -0.35 6.5e-11 Conotruncal heart defects (maternal effects); CRC cis rs6500602 0.727 rs8051389 chr16:4570570 C/T cg08645402 chr16:4508243 NA 0.64 11.48 0.53 7.03e-26 Schizophrenia; CRC cis rs28655083 0.828 rs11640648 chr16:77122494 T/C cg01753188 chr16:77233325 SYCE1L;MON1B 0.59 8.39 0.42 1.41e-15 Lobe attachment (rater-scored or self-reported); CRC cis rs4727027 0.901 rs4727019 chr7:148822266 A/G cg12479418 chr7:148823350 ZNF425;ZNF398 0.45 6.09 0.32 3.1e-9 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC cis rs367615 0.552 rs2963023 chr5:108730070 C/T cg17395555 chr5:108820864 NA -0.36 -6.95 -0.36 1.99e-11 Colorectal cancer (SNP x SNP interaction); CRC cis rs644148 0.836 rs2686774 chr19:44999827 T/C cg15540054 chr19:45004280 ZNF180 -0.58 -8.16 -0.41 7.05e-15 Personality dimensions; CRC cis rs6662572 0.703 rs7548617 chr1:46365489 C/A cg03123370 chr1:45965343 CCDC163P;MMACHC -0.46 -5.85 -0.31 1.21e-8 Blood protein levels; CRC cis rs7264396 0.635 rs2064724 chr20:34522520 T/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.64 -10.51 -0.5 1.86e-22 Total cholesterol levels; CRC cis rs9611565 0.649 rs79009 chr22:41860864 C/A cg06481639 chr22:41940642 POLR3H 0.54 6.37 0.33 6.45e-10 Vitiligo; CRC cis rs1005277 0.579 rs2505237 chr10:38438898 T/G cg25427524 chr10:38739819 LOC399744 -0.75 -13.32 -0.59 1.17e-32 Extrinsic epigenetic age acceleration; CRC cis rs2735413 0.794 rs55951868 chr16:78078804 C/A cg04733911 chr16:78082701 NA -0.48 -7.89 -0.4 4.61e-14 Systolic blood pressure (alcohol consumption interaction); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg07600211 chr1:145516081 GNRHR2;PEX11B 0.45 7.75 0.39 1.14e-13 Liver disease severity in Alagille syndrome; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg17181325 chr17:1613831 TLCD2 0.36 5.98 0.31 5.77e-9 Liver disease severity in Alagille syndrome; CRC cis rs3204270 0.639 rs11867543 chr17:79655046 C/T cg09655341 chr17:79618100 PDE6G 0.55 6.49 0.34 3.24e-10 Dental caries; CRC cis rs2408955 0.522 rs4760679 chr12:48461635 G/T cg00601486 chr12:48723148 H1FNT -0.35 -6.78 -0.35 5.75e-11 Glycated hemoglobin levels; CRC cis rs10744422 1.000 rs4759382 chr12:123347609 C/T cg25930673 chr12:123319894 HIP1R 0.52 5.79 0.3 1.69e-8 Schizophrenia; CRC trans rs629535 0.814 rs604254 chr8:70059164 A/G cg21567404 chr3:27674614 NA 0.93 15.7 0.65 7.26e-42 Dupuytren's disease; CRC cis rs9549260 0.755 rs3892360 chr13:41184078 C/G cg21288729 chr13:41239152 FOXO1 0.43 6.59 0.34 1.73e-10 Red blood cell count; CRC trans rs8073060 0.561 rs225260 chr17:33958422 T/C cg19694781 chr19:47549865 TMEM160 -1.04 -14.56 -0.63 2.1e-37 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; CRC trans rs60843830 0.623 rs55932737 chr2:107543 C/T cg11347411 chr7:150020925 ACTR3C;LRRC61 0.43 5.98 0.31 5.73e-9 Spherical equivalent (joint analysis main effects and education interaction); CRC cis rs7493 0.755 rs13223537 chr7:94966167 C/T cg17330251 chr7:94953956 PON1 0.49 6.34 0.33 7.53e-10 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs3018066 0.748 rs12512683 chr4:106999471 C/T cg01869342 chr4:106983673 TBCK 0.44 6.62 0.34 1.48e-10 Cancer; CRC cis rs370915 0.542 rs28440880 chr4:187793213 T/G cg12892747 chr4:187813459 NA -0.56 -8.07 -0.41 1.33e-14 Gout; CRC cis rs524281 0.648 rs10896089 chr11:65936292 A/G cg16950941 chr11:66035639 RAB1B -0.57 -7.12 -0.37 6.65e-12 Electroencephalogram traits; CRC cis rs9326248 1.000 rs664971 chr11:117070857 A/G cg26566898 chr11:117069891 TAGLN -0.46 -9.87 -0.48 2.66e-20 Blood protein levels; CRC cis rs1862618 0.853 rs832583 chr5:56178217 A/C cg03609598 chr5:56110824 MAP3K1 -0.85 -10.06 -0.49 6.18e-21 Initial pursuit acceleration; CRC cis rs12618769 0.625 rs2278207 chr2:99163261 T/A cg18455616 chr2:99124870 INPP4A 0.36 5.92 0.31 8.23e-9 Bipolar disorder; CRC cis rs7727544 0.735 rs4705933 chr5:131678412 G/A cg12564285 chr5:131593104 PDLIM4 0.32 5.82 0.31 1.36e-8 Blood metabolite levels; CRC cis rs6951245 0.706 rs28483034 chr7:1170171 C/A cg04025307 chr7:1156635 C7orf50 0.67 7.73 0.39 1.33e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs2457480 0.866 rs11238940 chr10:44721459 G/A cg09554077 chr10:44749378 NA 0.65 7.32 0.37 1.9e-12 Coronary artery disease; CRC cis rs7914558 0.902 rs3736922 chr10:104850632 A/G cg11453585 chr10:104263688 ACTR1A;SUFU 0.44 6.5 0.34 3.06e-10 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs2153535 0.580 rs9406159 chr6:8464859 C/G cg21535247 chr6:8435926 SLC35B3 0.49 7.37 0.38 1.35e-12 Motion sickness; CRC cis rs2688608 0.588 rs10128205 chr10:75469648 C/G cg16540259 chr10:75572220 NDST2 0.38 6.0 0.31 5.31e-9 Inflammatory bowel disease; CRC cis rs2303759 0.874 rs10411630 chr19:49891314 C/A cg24324837 chr19:49891574 CCDC155 0.58 8.15 0.41 7.45e-15 Multiple sclerosis; CRC trans rs57221529 0.766 rs56350081 chr5:583198 G/A cg25482853 chr8:67687455 SGK3 1.25 15.0 0.64 4.06e-39 Lung disease severity in cystic fibrosis; CRC cis rs68170813 0.559 rs74925723 chr7:106954536 G/C cg02696742 chr7:106810147 HBP1 -0.59 -6.54 -0.34 2.29e-10 Coronary artery disease; CRC cis rs769267 0.930 rs4808967 chr19:19640524 A/G cg03709012 chr19:19516395 GATAD2A 0.69 10.3 0.49 9.33e-22 Tonsillectomy; CRC cis rs12024301 0.557 rs9633304 chr1:183636878 A/T cg11505048 chr1:183622726 RGL1;APOBEC4 0.78 6.93 0.36 2.18e-11 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs13108904 0.870 rs11727987 chr4:1261435 A/G cg19318889 chr4:1322082 MAEA 0.39 5.67 0.3 3.14e-8 Obesity-related traits; CRC cis rs7772486 0.846 rs9376976 chr6:146355605 T/C cg23711669 chr6:146136114 FBXO30 0.68 11.85 0.55 3.34e-27 Lobe attachment (rater-scored or self-reported); CRC cis rs11997175 0.574 rs4733456 chr8:33656359 C/T ch.8.33884649F chr8:33765107 NA 0.47 7.73 0.39 1.34e-13 Body mass index; CRC trans rs7618501 0.521 rs11130222 chr3:49901060 A/T cg21665057 chr3:196295764 WDR53;FBXO45 0.5 7.03 0.36 1.23e-11 Intelligence (multi-trait analysis); CRC cis rs11252926 0.537 rs4554800 chr10:458477 G/T cg18196295 chr10:418757 DIP2C -0.48 -7.58 -0.39 3.57e-13 Psychosis in Alzheimer's disease; CRC cis rs2153535 0.580 rs1120392 chr6:8487053 C/A cg21535247 chr6:8435926 SLC35B3 0.5 7.51 0.38 5.54e-13 Motion sickness; CRC cis rs1005277 0.579 rs2474569 chr10:38383491 C/G cg25427524 chr10:38739819 LOC399744 -0.77 -13.64 -0.6 6.68e-34 Extrinsic epigenetic age acceleration; CRC cis rs7769051 0.522 rs6911773 chr6:133128848 T/C cg22852734 chr6:133119734 C6orf192 1.13 8.44 0.42 9.96e-16 Type 2 diabetes nephropathy; CRC cis rs533581 0.866 rs4995274 chr16:88970040 T/C cg09141835 chr16:88988174 CBFA2T3 -0.28 -6.12 -0.32 2.69e-9 Social autistic-like traits; CRC cis rs4728302 0.838 rs10224828 chr7:133591071 G/A cg03336402 chr7:133662267 EXOC4 -0.44 -6.41 -0.33 4.91e-10 Intelligence;Intelligence (multi-trait analysis); CRC cis rs7666738 0.830 rs7678567 chr4:99057346 A/G cg17366294 chr4:99064904 C4orf37 0.45 7.5 0.38 5.85e-13 Colonoscopy-negative controls vs population controls; CRC cis rs2404602 0.735 rs283789 chr15:76777577 G/A cg03037974 chr15:76606532 NA 0.56 8.69 0.43 1.75e-16 Blood metabolite levels; CRC cis rs4862750 0.872 rs13143414 chr4:187878213 G/A cg27532560 chr4:187881888 NA -0.58 -10.96 -0.52 4.9e-24 Lobe attachment (rater-scored or self-reported); CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg05002071 chr11:76510323 NA 0.49 6.28 0.33 1.06e-9 Thyroid stimulating hormone; CRC cis rs7617773 0.817 rs13100815 chr3:48287449 A/C cg11946769 chr3:48343235 NME6 0.73 9.8 0.48 4.71e-20 Coronary artery disease; CRC cis rs904251 0.797 rs1757177 chr6:37486370 C/T cg01843034 chr6:37503916 NA -0.45 -8.36 -0.42 1.77e-15 Cognitive performance; CRC cis rs7937682 0.575 rs12808601 chr11:111776066 G/A cg09085632 chr11:111637200 PPP2R1B 0.91 15.82 0.66 2.59e-42 Primary sclerosing cholangitis; CRC cis rs11098499 0.954 rs11729521 chr4:120416788 T/C cg24375607 chr4:120327624 NA 0.48 7.36 0.38 1.48e-12 Corneal astigmatism; CRC trans rs1455244 0.700 rs7229302 chr18:11508904 G/T cg19764325 chr22:32340710 C22orf24;YWHAH 0.35 6.23 0.32 1.44e-9 Schizophrenia; CRC cis rs6831352 0.918 rs1042365 chr4:100045500 G/T cg13256891 chr4:100009986 ADH5 -0.66 -8.94 -0.44 2.88e-17 Alcohol dependence; CRC cis rs853679 0.517 rs9357065 chr6:28129580 T/C cg06470822 chr6:28175283 NA 1.03 13.63 0.6 7.33e-34 Depression; CRC cis rs875971 0.660 rs10281080 chr7:66042441 T/C cg11764359 chr7:65958608 NA -0.55 -8.65 -0.43 2.36e-16 Aortic root size; CRC cis rs11711311 1.000 rs16861312 chr3:113492402 G/T cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.53 -7.18 -0.37 4.59e-12 IgG glycosylation; CRC cis rs7937682 0.889 rs490199 chr11:111487890 A/G cg09085632 chr11:111637200 PPP2R1B -0.96 -18.54 -0.71 4.92e-53 Primary sclerosing cholangitis; CRC cis rs2404602 0.716 rs2404737 chr15:76872217 T/G cg23625390 chr15:77176239 SCAPER 0.46 6.79 0.35 5.27e-11 Blood metabolite levels; CRC cis rs1799949 1.000 rs11653231 chr17:41331460 G/A cg19454999 chr17:41278357 BRCA1;NBR2 0.55 8.66 0.43 2.12e-16 Menopause (age at onset); CRC cis rs780096 0.526 rs3845686 chr2:27655447 T/G cg21248554 chr2:27665150 KRTCAP3 -0.34 -7.54 -0.38 4.48e-13 Total body bone mineral density; CRC trans rs2822999 0.932 rs12483192 chr21:16371613 A/G cg04886857 chr1:13914270 PDPN 0.39 6.0 0.31 5.18e-9 Breast cancer; CRC cis rs1005277 0.579 rs1740749 chr10:38521646 A/G cg17219203 chr10:38645113 HSD17B7P2 -0.41 -5.92 -0.31 8.11e-9 Extrinsic epigenetic age acceleration; CRC cis rs10416265 0.503 rs1981818 chr19:33615122 C/T cg17764715 chr19:33622953 WDR88 -0.49 -7.48 -0.38 6.82e-13 Bone properties (heel); CRC cis rs9914988 0.943 rs9908881 chr17:27100924 T/A cg12682573 chr17:27188876 MIR451;MIR144 0.58 7.99 0.4 2.37e-14 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs17270561 0.609 rs3922842 chr6:25736564 T/C cg16482183 chr6:26056742 HIST1H1C 0.83 10.58 0.5 1.07e-22 Iron status biomarkers; CRC trans rs208515 0.556 rs12206707 chr6:66697182 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.96 12.31 0.56 6.64e-29 Exhaled nitric oxide levels; CRC cis rs8060686 0.623 rs6499162 chr16:68239460 T/C cg26727032 chr16:67993705 SLC12A4 -0.62 -9.45 -0.46 6.7e-19 HDL cholesterol;Metabolic syndrome; CRC cis rs1799949 0.965 rs8176140 chr17:41251646 T/A cg01879757 chr17:41196368 BRCA1 -0.43 -6.48 -0.34 3.29e-10 Menopause (age at onset); CRC cis rs4073416 0.542 rs8010726 chr14:65932597 C/T cg03016385 chr14:66212404 NA -0.47 -6.44 -0.33 4.28e-10 N-glycan levels; CRC cis rs7677751 0.806 rs7673853 chr4:55096606 T/C cg17187183 chr4:55093834 PDGFRA 0.52 7.71 0.39 1.49e-13 Corneal astigmatism; CRC cis rs1784581 0.802 rs9365359 chr6:162423945 C/A cg17173639 chr6:162384350 PARK2 0.7 11.45 0.53 8.94e-26 Itch intensity from mosquito bite; CRC cis rs41271951 0.512 rs34761930 chr1:151089523 T/C cg11822372 chr1:151115635 SEMA6C -0.72 -5.81 -0.31 1.46e-8 Blood protein levels; CRC cis rs9467773 0.620 rs2451737 chr6:26619041 T/C cg09904177 chr6:26538194 HMGN4 0.72 11.21 0.53 6.63e-25 Intelligence (multi-trait analysis); CRC cis rs10504229 0.679 rs11783965 chr8:58130510 T/G cg21724239 chr8:58056113 NA 0.49 6.77 0.35 5.96e-11 Developmental language disorder (linguistic errors); CRC cis rs372883 0.901 rs13048365 chr21:30740394 T/C cg24692254 chr21:30365293 RNF160 0.38 5.69 0.3 2.78e-8 Pancreatic cancer; CRC cis rs9322193 0.923 rs1572229 chr6:150064977 T/A cg07701084 chr6:150067640 NUP43 0.61 9.16 0.45 5.53e-18 Lung cancer; CRC cis rs6089584 0.606 rs2273989 chr20:60579138 G/A cg13770153 chr20:60521292 NA -0.41 -6.5 -0.34 3.03e-10 Body mass index; CRC cis rs514406 0.929 rs1672909 chr1:53340824 A/G cg24675658 chr1:53192096 ZYG11B -0.56 -8.33 -0.42 2.15e-15 Monocyte count; CRC cis rs1799949 0.894 rs36062488 chr17:41337472 C/T cg05368731 chr17:41323189 NBR1 -0.61 -9.36 -0.46 1.32e-18 Menopause (age at onset); CRC cis rs6429082 0.783 rs291364 chr1:235687179 A/G cg26050004 chr1:235667680 B3GALNT2 0.63 9.55 0.47 3.01e-19 Adiposity; CRC cis rs2242116 0.761 rs6780601 chr3:46965856 A/G cg02527881 chr3:46936655 PTH1R -0.48 -8.35 -0.42 1.93e-15 Birth weight; CRC cis rs28386778 0.897 rs2665797 chr17:61922485 C/G cg25654072 chr17:61904446 PSMC5;FTSJ3 -0.69 -10.75 -0.51 2.63e-23 Prudent dietary pattern; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg14035508 chr11:124543525 SIAE;SPA17 0.48 6.88 0.35 3.1e-11 Response to antipsychotic treatment; CRC cis rs7224685 0.501 rs781850 chr17:3957124 C/T cg10724054 chr17:3904396 NA 0.46 7.56 0.38 4.16e-13 Type 2 diabetes; CRC cis rs7943191 0.805 rs12226821 chr11:62369018 C/G cg22862634 chr11:62369728 EML3;MTA2 0.52 8.39 0.42 1.42e-15 Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction); CRC cis rs939584 1.000 rs7574359 chr2:652542 T/C cg03610516 chr2:642275 NA -0.43 -5.93 -0.31 7.78e-9 Body mass index; CRC cis rs1046896 0.538 rs3803771 chr17:80687758 G/A cg08200770 chr17:80723486 TBCD 0.48 9.11 0.45 8.23e-18 Glycated hemoglobin levels; CRC cis rs875971 0.545 rs73136346 chr7:65566082 A/G cg18876405 chr7:65276391 NA -0.45 -6.09 -0.32 3.12e-9 Aortic root size; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg06766273 chr11:62521983 ZBTB3 0.5 6.5 0.34 3.06e-10 Thyroid stimulating hormone; CRC cis rs11105298 0.891 rs12369685 chr12:89928905 A/G cg00757033 chr12:89920650 WDR51B 0.4 6.46 0.34 3.68e-10 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg08413565 chr3:129035733 H1FX;C3orf47 0.51 6.55 0.34 2.15e-10 Thyroid stimulating hormone; CRC trans rs17685 0.712 rs11764119 chr7:75812358 T/G cg19862616 chr7:65841803 NCRNA00174 0.96 16.52 0.67 4.66e-45 Coffee consumption;Coffee consumption (cups per day); CRC cis rs561341 0.739 rs4795663 chr17:30214542 T/C cg00745463 chr17:30367425 LRRC37B 0.43 5.87 0.31 1.07e-8 Hip circumference adjusted for BMI; CRC trans rs1814175 0.647 rs4881649 chr11:49845560 A/G cg11707556 chr5:10655725 ANKRD33B -0.38 -7.02 -0.36 1.3e-11 Height; CRC cis rs9463078 0.565 rs10948183 chr6:44880881 T/C cg25276700 chr6:44698697 NA 0.26 6.15 0.32 2.31e-9 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; CRC cis rs735396 1.000 rs735396 chr12:121438844 T/C cg02403541 chr12:121454288 C12orf43 0.45 6.72 0.35 7.97e-11 N-glycan levels; CRC cis rs6502050 0.835 rs3088177 chr17:80111724 A/G cg19223190 chr17:80058835 NA 0.4 6.4 0.33 5.44e-10 Life satisfaction; CRC cis rs7208859 0.623 rs28556733 chr17:29083945 T/G cg01831904 chr17:28903510 LRRC37B2 -0.63 -6.53 -0.34 2.51e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC trans rs10411161 0.702 rs16983196 chr19:52384779 C/A cg22319618 chr22:45562946 NUP50 -0.69 -7.57 -0.39 3.9e-13 Breast cancer; CRC cis rs10504229 0.817 rs35207430 chr8:58167614 G/A cg05313129 chr8:58192883 C8orf71 -0.46 -7.14 -0.37 6.08e-12 Developmental language disorder (linguistic errors); CRC cis rs7773004 0.601 rs13210340 chr6:26326314 G/A cg00631329 chr6:26305371 NA -0.53 -8.79 -0.44 8.19e-17 Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for body mass index;Waist circumference adjusted for BMI in non-smokers;Waist circumference adjusted for BMI (adjusted for smoking behaviour); CRC cis rs950169 1.000 rs12903820 chr15:84723820 A/G cg11189052 chr15:85197271 WDR73 0.61 8.89 0.44 4.18e-17 Schizophrenia; CRC cis rs1957429 0.808 rs2357866 chr14:65336517 C/T cg23373153 chr14:65346875 NA 0.65 6.38 0.33 6.11e-10 Pediatric areal bone mineral density (radius); CRC cis rs6952808 0.771 rs10275045 chr7:1920826 C/T cg22963979 chr7:1858916 MAD1L1 -0.49 -7.71 -0.39 1.46e-13 Bipolar disorder and schizophrenia; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg22269622 chr17:60501544 METTL2A 0.55 7.34 0.38 1.64e-12 Thyroid stimulating hormone; CRC cis rs6570726 0.935 rs906774 chr6:145813770 T/C cg23711669 chr6:146136114 FBXO30 0.68 12.05 0.55 6.18e-28 Lobe attachment (rater-scored or self-reported); CRC cis rs9911578 1.000 rs7207693 chr17:57016525 C/T cg05425664 chr17:57184151 TRIM37 -0.49 -7.8 -0.39 8.34e-14 Intelligence (multi-trait analysis); CRC cis rs17401966 0.838 rs10492971 chr1:10342975 G/A cg19773385 chr1:10388646 KIF1B -0.67 -11.11 -0.52 1.45e-24 Hepatocellular carcinoma; CRC trans rs10982213 0.830 rs2274163 chr9:117188714 C/T cg08551857 chr8:82024104 PAG1 0.45 6.75 0.35 6.49e-11 Interleukin-6 levels; CRC cis rs6502050 0.805 rs11651863 chr17:80084539 T/C cg09264619 chr17:80180166 NA 0.36 6.02 0.32 4.59e-9 Life satisfaction; CRC cis rs2795502 1.000 rs1852959 chr10:43359636 T/C cg27426351 chr10:43362370 NA 0.62 7.4 0.38 1.14e-12 Blood protein levels; CRC trans rs453301 0.682 rs2929451 chr8:9085295 A/T cg16141378 chr3:129829833 LOC729375 -0.41 -6.2 -0.32 1.67e-9 Joint mobility (Beighton score); CRC cis rs28386778 0.897 rs2727333 chr17:61876023 G/A cg07362569 chr17:61921086 SMARCD2 0.39 5.99 0.31 5.59e-9 Prudent dietary pattern; CRC cis rs7618915 0.501 rs2164885 chr3:52731269 T/C cg18404041 chr3:52824283 ITIH1 -0.4 -8.31 -0.42 2.46e-15 Bipolar disorder; CRC cis rs9372498 0.536 rs9489394 chr6:118758234 T/C cg01339444 chr6:118972232 C6orf204 0.52 5.9 0.31 8.98e-9 Diastolic blood pressure; CRC cis rs3858526 0.883 rs11039584 chr11:5935251 C/G cg02574844 chr11:5959923 NA -0.42 -5.87 -0.31 1.09e-8 DNA methylation (variation); CRC cis rs2859741 0.546 rs3845491 chr1:37497521 C/T cg09363841 chr1:37513479 NA -0.46 -7.25 -0.37 2.92e-12 Forced expiratory volume in 1 second (environmental tobacco smoke interaction); CRC cis rs9322193 0.923 rs9767554 chr6:149937996 T/C cg00933542 chr6:150070202 PCMT1 0.29 5.9 0.31 9.18e-9 Lung cancer; CRC cis rs514406 0.895 rs1925673 chr1:53326984 T/G cg25767906 chr1:53392781 SCP2 -0.46 -7.39 -0.38 1.26e-12 Monocyte count; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg14561881 chr17:62503076 CCDC45;DDX5 0.48 6.16 0.32 2.15e-9 Thyroid stimulating hormone; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg02459971 chr11:798364 NA 0.41 6.38 0.33 5.94e-10 Liver disease severity in Alagille syndrome; CRC trans rs2797160 0.967 rs2797159 chr6:126009557 G/A cg05039488 chr6:79577232 IRAK1BP1 0.49 7.29 0.37 2.25e-12 Endometrial cancer; CRC trans rs10982213 0.830 rs2274163 chr9:117188714 C/T cg12564526 chr7:66767603 PMS2L4;STAG3L4 0.41 6.48 0.34 3.4e-10 Interleukin-6 levels; CRC cis rs910316 1.000 rs7156105 chr14:75541954 C/A cg08847533 chr14:75593920 NEK9 0.95 18.84 0.72 3.13e-54 Height; CRC cis rs262150 0.574 rs2730272 chr7:158798622 G/C cg19418458 chr7:158789849 NA -0.47 -8.15 -0.41 7.79e-15 Facial morphology (factor 20); CRC trans rs72991 0.686 rs903243 chr11:121259106 C/G cg27192990 chr6:129479024 LAMA2 0.37 6.17 0.32 2.02e-9 Response to tocilizumab in rheumatoid arthritis; CRC cis rs7618915 0.501 rs35526119 chr3:52749334 C/T cg10802521 chr3:52805072 NEK4 -0.58 -9.05 -0.45 1.31e-17 Bipolar disorder; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg17548431 chr4:160024475 NA 0.41 6.82 0.35 4.33e-11 Liver disease severity in Alagille syndrome; CRC cis rs4523957 0.579 rs903161 chr17:2092006 A/T cg16513277 chr17:2031491 SMG6 -0.58 -9.84 -0.48 3.46e-20 Autism spectrum disorder or schizophrenia;Schizophrenia; CRC cis rs11583043 1.000 rs2391573 chr1:101489698 T/C cg16556008 chr1:101360663 SLC30A7;EXTL2 0.44 5.65 0.3 3.49e-8 Ulcerative colitis;Inflammatory bowel disease; CRC cis rs7809950 0.954 rs2520242 chr7:107136320 G/T cg23024343 chr7:107201750 COG5 0.62 8.91 0.44 3.65e-17 Coronary artery disease; CRC cis rs11155671 0.530 rs9383940 chr6:150226059 T/G cg13206674 chr6:150067644 NUP43 0.44 6.31 0.33 9.1e-10 Testicular germ cell tumor; CRC cis rs3785574 0.962 rs2727332 chr17:61878584 T/A cg22520471 chr17:61851767 DDX42;CCDC47 0.47 6.51 0.34 2.84e-10 Height; CRC cis rs853679 0.517 rs35193936 chr6:28076270 A/G cg18032046 chr6:28092343 ZSCAN16 -0.5 -5.89 -0.31 9.34e-9 Depression; CRC cis rs1475911 0.671 rs12483409 chr21:43521902 G/A cg24372256 chr21:43528868 UMODL1;C21orf128 -0.65 -9.95 -0.48 1.42e-20 IgG glycosylation; CRC cis rs7666738 0.830 rs4443293 chr4:99063120 G/A cg05340658 chr4:99064831 C4orf37 0.6 9.38 0.46 1.1e-18 Colonoscopy-negative controls vs population controls; CRC cis rs2645694 0.626 rs2645704 chr4:77830805 T/C cg03477792 chr4:77819574 ANKRD56 0.46 6.62 0.34 1.49e-10 Emphysema distribution in smoking; CRC cis rs116095464 0.558 rs10065584 chr5:253997 G/A cg22496380 chr5:211416 CCDC127 -1.0 -10.06 -0.48 6.41e-21 Breast cancer; CRC cis rs838147 0.508 rs507711 chr19:49208564 C/T cg21064579 chr19:49206444 FUT2 0.47 8.26 0.41 3.51e-15 Dietary macronutrient intake; CRC cis rs4853012 0.775 rs12465641 chr2:74337715 A/G cg19729930 chr2:74357872 NA -0.68 -10.58 -0.5 1.04e-22 Gestational age at birth (maternal effect); CRC cis rs4843747 0.671 rs8053377 chr16:88106465 A/G cg17633681 chr16:88106987 BANP 0.87 16.24 0.67 5.81e-44 Menopause (age at onset); CRC cis rs2952156 0.876 rs903504 chr17:37829570 C/G cg07936489 chr17:37558343 FBXL20 -0.42 -5.97 -0.31 6.2e-9 Asthma; CRC cis rs561341 0.769 rs559228 chr17:30294527 T/C cg12193833 chr17:30244370 NA -0.74 -8.72 -0.43 1.45e-16 Hip circumference adjusted for BMI; CRC trans rs7618501 1.000 rs34614773 chr3:49753003 T/G cg21659725 chr3:3221576 CRBN -0.91 -17.84 -0.7 2.75e-50 Intelligence (multi-trait analysis); CRC cis rs2108225 0.967 rs6466189 chr7:107448516 C/T cg18560240 chr7:107437656 SLC26A3 -0.54 -8.43 -0.42 1.09e-15 Ulcerative colitis; CRC cis rs17270561 1.000 rs12200962 chr6:25828986 T/C cg17691542 chr6:26056736 HIST1H1C 0.84 9.52 0.46 3.83e-19 Iron status biomarkers; CRC cis rs832540 0.931 rs1445996 chr5:56235548 C/T cg24531977 chr5:56204891 C5orf35 0.46 7.03 0.36 1.21e-11 Coronary artery disease; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg00597366 chr16:46917883 GPT2 0.43 6.15 0.32 2.3e-9 Intelligence (multi-trait analysis); CRC cis rs7705042 0.865 rs2043280 chr5:141513691 C/G cg08523384 chr5:141488047 NDFIP1 0.32 5.68 0.3 2.98e-8 Asthma; CRC cis rs9807989 0.507 rs11465721 chr2:103063240 T/G cg03938978 chr2:103052716 IL18RAP 0.59 10.26 0.49 1.27e-21 Asthma; CRC trans rs10435719 0.753 rs9694940 chr8:11789858 G/C cg06636001 chr8:8085503 FLJ10661 0.49 7.33 0.37 1.82e-12 C-reactive protein levels or triglyceride levels (pleiotropy); CRC cis rs7772486 0.686 rs857879 chr6:145974043 C/A cg13319975 chr6:146136371 FBXO30 0.43 6.4 0.33 5.37e-10 Lobe attachment (rater-scored or self-reported); CRC cis rs10256972 0.732 rs12701856 chr7:1107707 C/T cg07308232 chr7:1071921 C7orf50 -0.48 -6.59 -0.34 1.72e-10 Longevity;Endometriosis; CRC cis rs7607369 0.719 rs7567622 chr2:219624549 A/T cg02176678 chr2:219576539 TTLL4 -0.39 -6.31 -0.33 8.79e-10 Red blood cell count;Amyotrophic lateral sclerosis; CRC trans rs7618501 0.633 rs3774733 chr3:50037123 C/G cg21665057 chr3:196295764 WDR53;FBXO45 0.61 9.54 0.47 3.33e-19 Intelligence (multi-trait analysis); CRC trans rs7746199 0.736 rs17693963 chr6:27710165 A/C cg12315302 chr6:26189340 HIST1H4D 0.94 6.52 0.34 2.69e-10 Gait speed in old age;Autism spectrum disorder or schizophrenia; CRC cis rs4862750 0.914 rs11945845 chr4:187874136 T/C cg03452623 chr4:187889614 NA -0.89 -20.13 -0.74 2.57e-59 Lobe attachment (rater-scored or self-reported); CRC cis rs1862618 0.525 rs832403 chr5:56265992 G/T cg24531977 chr5:56204891 C5orf35 0.92 12.74 0.57 1.68e-30 Initial pursuit acceleration; CRC cis rs1018836 0.923 rs6986001 chr8:91650205 T/C cg16814680 chr8:91681699 NA -0.8 -13.13 -0.59 5.8e-32 Ejection fraction in Tripanosoma cruzi seropositivity; CRC cis rs9372498 0.536 rs9489442 chr6:118885950 A/C cg07617317 chr6:118971624 C6orf204 0.5 6.21 0.32 1.56e-9 Diastolic blood pressure; CRC cis rs4805272 0.626 rs12608533 chr19:29331405 C/G cg12756686 chr19:29218302 NA 0.45 6.34 0.33 7.57e-10 Plasma omega-3 polyunsaturated fatty acid levels (docosahexaenoic acid); CRC cis rs6060960 0.537 rs6089103 chr20:30464919 G/T cg13852791 chr20:30311386 BCL2L1 0.54 7.03 0.36 1.18e-11 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; CRC cis rs1580019 0.587 rs7806113 chr7:32553084 A/G cg06627557 chr7:32535165 LSM5;AVL9 0.96 18.4 0.71 1.71e-52 Cognitive ability; CRC cis rs5758511 0.680 rs1107554 chr22:42667594 C/G cg00645731 chr22:42541494 CYP2D7P1 0.62 9.4 0.46 9.51e-19 Birth weight; CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg21528620 chr1:110753221 KCNC4 0.37 5.98 0.31 5.84e-9 Obesity-related traits; CRC trans rs3780486 0.846 rs7849148 chr9:33138352 A/T cg20290983 chr6:43655470 MRPS18A 1.17 24.99 0.81 5.35e-78 IgG glycosylation; CRC cis rs1799949 0.501 rs35399157 chr17:41411602 G/C cg05368731 chr17:41323189 NBR1 0.67 10.08 0.49 5.26e-21 Menopause (age at onset); CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg01540024 chr16:19729665 C16orf88;IQCK 0.45 5.97 0.31 6.11e-9 Anxiety disorder; CRC cis rs365302 1.000 rs375423 chr6:159648956 A/G cg14500486 chr6:159655392 FNDC1 0.44 6.82 0.35 4.31e-11 Coronary heart disease; CRC cis rs1838105 0.510 rs3851795 chr17:45061077 A/G cg16759221 chr17:45003025 GOSR2 0.43 6.26 0.33 1.22e-9 Nonsyndromic cleft lip with cleft palate; CRC cis rs35110281 0.811 rs1122873 chr21:45044672 G/C cg04455712 chr21:45112962 RRP1B 0.41 8.05 0.41 1.55e-14 Mean corpuscular volume; CRC cis rs1552244 1.000 rs35198334 chr3:10104553 G/C cg18598329 chr3:10140678 FANCD2;C3orf24 -0.86 -11.36 -0.53 1.9e-25 Alzheimer's disease; CRC cis rs7615952 0.599 rs6438953 chr3:125724951 T/C cg05084668 chr3:125655381 ALG1L -0.52 -8.43 -0.42 1.13e-15 Blood pressure (smoking interaction); CRC trans rs2012709 0.840 rs58390450 chr5:32575881 A/G cg03755955 chr8:6424269 MCPH1 0.45 6.83 0.35 4.09e-11 Breast cancer; CRC cis rs3772130 0.962 rs6768621 chr3:121530274 C/A cg20356878 chr3:121714668 ILDR1 0.51 7.94 0.4 3.22e-14 Cognitive performance; CRC cis rs34779708 0.733 rs16935948 chr10:35549748 C/G cg03585969 chr10:35415529 CREM 0.48 6.0 0.31 5.07e-9 Inflammatory bowel disease;Crohn's disease; CRC cis rs57221529 0.766 rs28563961 chr5:554498 C/G cg16035780 chr5:759353 NA 0.43 5.79 0.3 1.67e-8 Lung disease severity in cystic fibrosis; CRC cis rs2840044 0.517 rs2124247 chr17:33885468 G/A cg05299278 chr17:33885742 SLFN14 0.52 8.54 0.43 5.1e-16 Response to radiotherapy in cancer (late toxicity); CRC cis rs7520050 0.645 rs1768809 chr1:46502836 A/C cg03146154 chr1:46216737 IPP -0.39 -5.81 -0.31 1.46e-8 Red blood cell count;Reticulocyte count; CRC cis rs8062405 0.964 rs72793809 chr16:28832382 C/T cg16576597 chr16:28551801 NUPR1 0.49 7.07 0.36 9.42e-12 Cognitive ability (multi-trait analysis);Cognitive ability; CRC cis rs801193 1.000 rs2420824 chr7:66131116 G/A cg11764359 chr7:65958608 NA -0.53 -8.21 -0.41 4.93e-15 Aortic root size; CRC cis rs875971 1.000 rs10244498 chr7:66116056 A/G cg18252515 chr7:66147081 NA -0.39 -5.65 -0.3 3.43e-8 Aortic root size; CRC cis rs6752107 0.967 rs36001488 chr2:234185267 C/T cg07618928 chr2:234183455 ATG16L1;SCARNA5 0.66 11.5 0.54 5.74e-26 Crohn's disease;Inflammatory bowel disease; CRC cis rs11212617 0.901 rs4754301 chr11:108048541 G/A cg12106634 chr11:108092400 ATM;NPAT 0.42 6.3 0.33 9.42e-10 Response to metformin in type 2 diabetes (glycemic); CRC cis rs394563 0.726 rs6906384 chr6:149664540 G/A cg03678062 chr6:149772716 ZC3H12D 0.36 6.58 0.34 1.86e-10 Dupuytren's disease; CRC cis rs3008870 1.000 rs3008859 chr1:67390999 G/C cg08660285 chr1:67390436 MIER1;WDR78 1.02 15.14 0.64 1.16e-39 Lymphocyte percentage of white cells; CRC trans rs875971 0.660 rs2191268 chr7:66110224 C/T cg07261734 chr13:49684383 FNDC3A -0.42 -6.78 -0.35 5.43e-11 Aortic root size; CRC cis rs908922 0.887 rs6587688 chr1:152529622 C/T cg23254163 chr1:152506842 NA -0.44 -7.58 -0.39 3.61e-13 Hair morphology; CRC cis rs2745959 0.611 rs2466574 chr1:208053853 A/G cg09788693 chr1:208063733 CD34 0.47 6.21 0.32 1.56e-9 Resting heart rate; CRC cis rs1150668 0.796 rs2531825 chr6:28349264 C/T cg15845792 chr6:28175446 NA 0.46 6.72 0.35 7.87e-11 Pubertal anthropometrics; CRC cis rs3741404 0.665 rs12418535 chr11:63910980 A/G cg05016508 chr11:63871570 FLRT1;MACROD1 0.44 6.53 0.34 2.55e-10 Platelet count; CRC cis rs11098499 1.000 rs12506395 chr4:120185094 C/T cg09307838 chr4:120376055 NA 0.62 9.48 0.46 5.06e-19 Corneal astigmatism; CRC cis rs10782582 0.609 rs111914775 chr1:76319036 C/T cg03433033 chr1:76189801 ACADM -0.41 -5.88 -0.31 1.02e-8 Daytime sleep phenotypes; CRC cis rs10504229 0.953 rs75585481 chr8:58192202 T/C cg05313129 chr8:58192883 C8orf71 -0.47 -6.99 -0.36 1.49e-11 Developmental language disorder (linguistic errors); CRC trans rs11039798 0.588 rs11039782 chr11:48524785 A/G cg15704280 chr7:45808275 SEPT13 0.63 6.45 0.34 4.08e-10 Axial length; CRC cis rs1218582 0.774 rs4845683 chr1:154877407 T/C cg16680214 chr1:154839983 KCNN3 -0.48 -9.34 -0.46 1.52e-18 Prostate cancer; CRC cis rs1215050 0.755 rs9991112 chr4:98651479 A/C cg05340658 chr4:99064831 C4orf37 -0.46 -6.86 -0.35 3.41e-11 Waist-to-hip ratio adjusted for body mass index; CRC cis rs1580019 0.813 rs2044839 chr7:32500805 A/C cg14728415 chr7:32535168 LSM5;AVL9 0.43 5.68 0.3 2.96e-8 Cognitive ability; CRC cis rs6912958 0.684 rs4707382 chr6:88320641 T/C cg12350822 chr6:88032061 C6orf162;GJB7 -0.32 -5.99 -0.31 5.46e-9 Monocyte percentage of white cells; CRC cis rs2249625 0.545 rs2249021 chr6:72889472 A/G cg18830697 chr6:72922368 RIMS1 -0.39 -7.96 -0.4 2.85e-14 Acute urticaria and angioedema (non-steroidal anti-inflammatory drug-induced); CRC cis rs10504229 0.639 rs16921812 chr8:58106737 C/T cg05313129 chr8:58192883 C8orf71 -0.43 -5.87 -0.31 1.09e-8 Developmental language disorder (linguistic errors); CRC cis rs738322 0.640 rs738321 chr22:38568833 C/G cg25457927 chr22:38595422 NA -0.32 -6.38 -0.33 6e-10 Cutaneous nevi; CRC cis rs561341 1.000 rs527256 chr17:30321293 C/G cg12193833 chr17:30244370 NA -0.76 -8.87 -0.44 4.62e-17 Hip circumference adjusted for BMI; CRC cis rs9467711 0.606 rs12176317 chr6:26372786 A/G cg16898833 chr6:26189333 HIST1H4D 0.76 6.58 0.34 1.84e-10 Autism spectrum disorder or schizophrenia; CRC cis rs853679 0.517 rs56364346 chr6:28050762 T/G cg03623178 chr6:28175578 NA 0.94 12.29 0.56 7.67e-29 Depression; CRC cis rs2742540 0.505 rs2742493 chr11:8967592 A/C cg00186954 chr11:8933980 ST5;C11orf17 0.52 9.24 0.45 3.06e-18 Hematocrit; CRC cis rs172166 0.694 rs203876 chr6:28046673 T/C cg15786705 chr6:28176104 NA 0.61 8.72 0.43 1.35e-16 Cardiac Troponin-T levels; CRC cis rs7119 0.717 rs8033067 chr15:77825495 G/T cg27398640 chr15:77910606 LINGO1 -0.44 -7.52 -0.38 5.19e-13 Type 2 diabetes; CRC cis rs7914558 1.000 rs7914558 chr10:104775908 G/A cg15744005 chr10:104629667 AS3MT -0.32 -6.87 -0.35 3.16e-11 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs1183201 0.505 rs1165201 chr6:25874823 A/C cg12310025 chr6:25882481 NA -0.79 -12.14 -0.56 2.73e-28 Uric acid levels; CRC cis rs7731657 0.537 rs10062336 chr5:130193668 T/A cg08523029 chr5:130500466 HINT1 -0.46 -5.86 -0.31 1.11e-8 Fasting plasma glucose; CRC cis rs6732160 0.932 rs6546803 chr2:73381315 C/G cg01422370 chr2:73384389 NA 0.33 5.67 0.3 3.17e-8 Intelligence (multi-trait analysis); CRC cis rs853679 0.517 rs9380060 chr6:28132603 G/A cg15786705 chr6:28176104 NA 0.78 9.83 0.48 3.57e-20 Depression; CRC cis rs4664308 0.618 rs62175487 chr2:160892521 C/T cg03641300 chr2:160917029 PLA2R1 -0.56 -8.43 -0.42 1.08e-15 Idiopathic membranous nephropathy; CRC cis rs2249625 0.545 rs55681410 chr6:72877859 G/A cg18830697 chr6:72922368 RIMS1 0.41 8.02 0.4 1.86e-14 Acute urticaria and angioedema (non-steroidal anti-inflammatory drug-induced); CRC cis rs4713118 0.662 rs149969 chr6:27977737 A/G cg12172441 chr6:28176163 NA 0.58 7.9 0.4 4.21e-14 Parkinson's disease; CRC cis rs11792861 0.926 rs12686736 chr9:111888739 A/G cg05043794 chr9:111880884 C9orf5 -0.34 -6.28 -0.33 1.08e-9 Menarche (age at onset); CRC cis rs7845219 0.544 rs9643351 chr8:95917290 C/T cg16049864 chr8:95962084 TP53INP1 -0.44 -6.72 -0.35 7.82e-11 Type 2 diabetes; CRC cis rs4523957 0.583 rs8067895 chr17:2030234 G/A cg16513277 chr17:2031491 SMG6 -0.69 -11.89 -0.55 2.34e-27 Autism spectrum disorder or schizophrenia;Schizophrenia; CRC cis rs6762 0.748 rs7936838 chr11:839093 G/C cg15787769 chr11:842744 TSPAN4;POLR2L -0.46 -6.57 -0.34 2.01e-10 Mean platelet volume; CRC cis rs9463078 0.715 rs1891411 chr6:44760903 G/C cg25276700 chr6:44698697 NA 0.29 7.03 0.36 1.23e-11 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; CRC cis rs17780086 0.527 rs72827711 chr17:30537920 T/A cg19193384 chr17:30244184 NA -0.6 -6.01 -0.31 4.96e-9 Height; CRC cis rs6951245 1.000 rs78308415 chr7:1072634 G/A cg22907277 chr7:1156413 C7orf50 0.7 7.23 0.37 3.37e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs1218582 0.772 rs10796934 chr1:154849479 C/G cg24250549 chr1:154909240 PMVK 0.63 10.86 0.51 1.07e-23 Prostate cancer; CRC cis rs10504229 1.000 rs55787104 chr8:58178519 C/T cg02725872 chr8:58115012 NA -0.37 -6.29 -0.33 1e-9 Developmental language disorder (linguistic errors); CRC cis rs875971 0.545 rs4718335 chr7:65804606 C/T cg05627663 chr7:65219948 SNORA22;CCT6P1 0.61 7.93 0.4 3.53e-14 Aortic root size; CRC cis rs4665809 0.590 rs10495756 chr2:26485586 A/G cg26119090 chr2:26468346 HADHA;HADHB 1.06 15.53 0.65 3.62e-41 Gut microbiome composition (summer); CRC cis rs1218582 0.596 rs906595 chr1:154822907 C/T cg09359103 chr1:154839909 KCNN3 -0.56 -8.4 -0.42 1.35e-15 Prostate cancer; CRC cis rs1799949 1.000 rs8176202 chr17:41230228 G/A cg23758822 chr17:41437982 NA 0.82 13.74 0.6 2.79e-34 Menopause (age at onset); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg10170637 chr12:49110646 CCNT1 0.38 6.06 0.32 3.74e-9 Liver disease severity in Alagille syndrome; CRC cis rs11724804 0.532 rs7657611 chr4:880558 G/C cg20814179 chr4:940893 TMEM175 0.61 10.47 0.5 2.56e-22 Primary biliary cholangitis;Limited cutaneous systemic scleroderma; CRC cis rs6484504 0.532 rs10835757 chr11:31281902 C/T cg14844989 chr11:31128820 NA -0.36 -6.33 -0.33 8.06e-10 Red blood cell count; CRC cis rs11190604 0.767 rs7392696 chr10:102182141 G/A cg07080220 chr10:102295463 HIF1AN 0.47 5.75 0.3 2.08e-8 Palmitoleic acid (16:1n-7) levels; CRC cis rs11077998 0.967 rs4789782 chr17:80489323 G/T cg10255544 chr17:80519551 FOXK2 -0.39 -6.14 -0.32 2.34e-9 Reticulocyte fraction of red cells; CRC cis rs9906695 0.950 rs11868941 chr17:32562941 C/T cg12698626 chr17:32581466 CCL2 0.4 5.61 0.3 4.25e-8 Monocyte percentage of white cells; CRC cis rs6952808 0.595 rs2398705 chr7:2164995 G/A cg04267008 chr7:1944627 MAD1L1 -0.69 -9.45 -0.46 6.64e-19 Bipolar disorder and schizophrenia; CRC cis rs2066819 1.000 rs2306694 chr12:56680636 C/T cg26714650 chr12:56694279 CS 1.41 11.82 0.55 4.19e-27 Psoriasis vulgaris; CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg22159483 chr17:1588198 PRPF8 -0.54 -6.65 -0.34 1.26e-10 Diisocyanate-induced asthma; CRC cis rs10771431 0.810 rs10771418 chr12:9358995 A/G cg22349387 chr12:9600060 DDX12 -0.4 -6.4 -0.33 5.47e-10 Breast size; CRC cis rs28386778 0.863 rs2597633 chr17:61872871 T/C cg25654072 chr17:61904446 PSMC5;FTSJ3 0.72 11.24 0.53 5.2e-25 Prudent dietary pattern; CRC cis rs6908034 0.607 rs77791009 chr6:19812602 A/G cg02682789 chr6:19804855 NA 0.81 6.48 0.34 3.35e-10 Endometriosis;Deep ovarian and/or rectovaginal disease with dense adhesions; CRC cis rs9388451 0.626 rs3799708 chr6:126078530 C/T cg05901451 chr6:126070800 HEY2 -0.53 -8.89 -0.44 4.05e-17 Brugada syndrome; CRC cis rs600806 0.850 rs115935180 chr1:109976775 C/G cg23032129 chr1:109941072 SORT1 -0.28 -6.06 -0.32 3.77e-9 Intelligence (multi-trait analysis); CRC cis rs6764363 0.587 rs35762438 chr3:279853 G/C cg02057681 chr3:285234 CHL1 0.44 7.4 0.38 1.14e-12 Sudden cardiac arrest; CRC cis rs4750440 0.637 rs2457859 chr10:14032099 T/G cg00551146 chr10:14014579 FRMD4A 0.45 8.06 0.41 1.42e-14 Adiponectin levels; CRC cis rs4332037 0.539 rs56180486 chr7:2050747 C/T cg21155852 chr7:2048760 MAD1L1 -0.53 -6.96 -0.36 1.8e-11 Bipolar disorder; CRC trans rs11148252 0.538 rs9535887 chr13:52730761 G/A cg18335740 chr13:41363409 SLC25A15 0.54 8.0 0.4 2.17e-14 Lewy body disease; CRC cis rs6942756 1.000 rs12112374 chr7:128950071 A/G cg02491457 chr7:128862824 NA -0.76 -10.46 -0.5 2.65e-22 White matter hyperintensity burden; CRC cis rs870825 0.698 rs7673203 chr4:185625397 T/C cg04058563 chr4:185651563 MLF1IP 0.72 9.38 0.46 1.12e-18 Blood protein levels; CRC cis rs892961 0.932 rs6501954 chr17:75414398 G/C cg05865280 chr17:75406074 SEPT9 0.62 14.15 0.62 7.52e-36 Airflow obstruction; CRC cis rs11764590 0.694 rs6972969 chr7:2099331 A/G cg23422044 chr7:1970798 MAD1L1 -0.41 -5.67 -0.3 3.07e-8 Neuroticism; CRC cis rs1707322 1.000 rs11211239 chr1:46451947 A/G cg06784218 chr1:46089804 CCDC17 0.51 8.96 0.44 2.39e-17 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs7666738 0.830 rs34628820 chr4:99004764 C/T cg05340658 chr4:99064831 C4orf37 0.61 9.54 0.47 3.44e-19 Colonoscopy-negative controls vs population controls; CRC cis rs2239547 0.522 rs9844736 chr3:52931971 T/G cg11645453 chr3:52864694 ITIH4 -0.52 -9.14 -0.45 6.82e-18 Schizophrenia; CRC cis rs9527 0.590 rs7910900 chr10:104829898 C/T cg15744005 chr10:104629667 AS3MT -0.31 -6.21 -0.32 1.64e-9 Arsenic metabolism; CRC cis rs6121246 0.909 rs57726761 chr20:30314046 A/G cg18721089 chr20:30220636 NA -0.34 -5.64 -0.3 3.75e-8 Mean corpuscular hemoglobin; CRC cis rs9903692 0.909 rs2325885 chr17:46290375 C/T cg21215337 chr17:46176117 CBX1 0.43 7.83 0.4 6.68e-14 Pulse pressure; CRC cis rs911555 0.723 rs6575991 chr14:103908433 C/T cg12935359 chr14:103987150 CKB 0.56 9.13 0.45 7.33e-18 Intelligence (multi-trait analysis); CRC cis rs8177253 0.965 rs3811658 chr3:133476852 C/T cg01448562 chr3:133502909 NA -0.52 -8.91 -0.44 3.68e-17 Iron status biomarkers; CRC cis rs7589728 0.563 rs79892776 chr2:88470593 G/A cg04511125 chr2:88470314 THNSL2 0.81 8.58 0.43 3.87e-16 Plasma clusterin levels; CRC cis rs35306767 0.903 rs61830933 chr10:934195 G/A cg20503657 chr10:835505 NA 1.24 14.87 0.63 1.34e-38 Eosinophil percentage of granulocytes; CRC cis rs2836633 0.929 rs2836610 chr21:40044502 C/T cg05519781 chr21:40033154 ERG 0.67 12.76 0.58 1.47e-30 Coronary artery disease; CRC cis rs10504229 0.636 rs77753517 chr8:58115897 C/T cg04204079 chr8:58130323 NA -0.45 -5.78 -0.3 1.71e-8 Developmental language disorder (linguistic errors); CRC cis rs9311676 0.656 rs11721168 chr3:58408679 G/A cg06643156 chr3:58380774 PXK 0.42 6.38 0.33 5.84e-10 Systemic lupus erythematosus; CRC trans rs820077 0.557 rs9366880 chr6:35144651 G/A cg23173586 chr14:20945319 PNP -0.29 -6.03 -0.32 4.43e-9 Systemic lupus erythematosus; CRC cis rs7412746 0.634 rs2124952 chr1:150923774 T/A cg17724175 chr1:150552817 MCL1 0.44 6.69 0.35 9.45e-11 Melanoma; CRC trans rs10504229 0.861 rs6990617 chr8:58182960 G/T cg04077850 chr5:125800366 GRAMD3 0.37 6.27 0.33 1.15e-9 Developmental language disorder (linguistic errors); CRC cis rs736408 0.677 rs2286798 chr3:52821177 G/T cg07507251 chr3:52567010 NT5DC2 -0.42 -6.16 -0.32 2.11e-9 Bipolar disorder; CRC cis rs910316 0.763 rs12588981 chr14:75460561 A/G cg08847533 chr14:75593920 NEK9 0.85 14.57 0.63 1.85e-37 Height; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg03153608 chr11:64126457 RPS6KA4 0.4 6.0 0.31 5.12e-9 Intelligence (multi-trait analysis); CRC cis rs7647973 0.580 rs2117938 chr3:49263850 A/G cg07636037 chr3:49044803 WDR6 -0.82 -12.75 -0.58 1.51e-30 Menarche (age at onset); CRC trans rs2797160 0.904 rs1612274 chr6:126014907 C/A cg05039488 chr6:79577232 IRAK1BP1 0.6 9.32 0.46 1.79e-18 Endometrial cancer; CRC cis rs6433857 0.536 rs1971134 chr2:181351532 G/A cg23363182 chr2:181467187 NA -0.55 -8.11 -0.41 9.84e-15 Body mass index; CRC cis rs11098499 1.000 rs13435802 chr4:120177960 A/T cg09307838 chr4:120376055 NA -0.61 -9.11 -0.45 8.53e-18 Corneal astigmatism; CRC cis rs7618915 0.547 rs13085895 chr3:52678270 G/C cg18404041 chr3:52824283 ITIH1 -0.43 -8.82 -0.44 7.03e-17 Bipolar disorder; CRC cis rs10504229 0.953 rs75545548 chr8:58172816 T/C cg24829409 chr8:58192753 C8orf71 -0.68 -11.34 -0.53 2.27e-25 Developmental language disorder (linguistic errors); CRC cis rs250677 1.000 rs40525 chr5:148432932 G/T cg23229984 chr5:148520753 ABLIM3 -0.48 -6.49 -0.34 3.23e-10 Breast cancer; CRC cis rs713477 0.967 rs4901568 chr14:55912789 T/A cg13175173 chr14:55914753 NA -0.53 -10.13 -0.49 3.74e-21 Pediatric bone mineral content (femoral neck); CRC cis rs4692589 0.965 rs2291167 chr4:170950887 G/A cg19918862 chr4:170955249 NA 0.4 6.35 0.33 6.99e-10 Anxiety disorder; CRC cis rs60871478 1.000 rs4397290 chr7:828493 T/C cg04727924 chr7:799746 HEATR2 0.43 6.24 0.33 1.31e-9 Cerebrospinal P-tau181p levels; CRC cis rs9372498 0.505 rs17427284 chr6:118991953 A/T cg15382696 chr6:118971807 C6orf204 0.58 6.99 0.36 1.58e-11 Diastolic blood pressure; CRC trans rs1814175 0.817 rs10769618 chr11:49822336 A/G cg11707556 chr5:10655725 ANKRD33B -0.42 -7.83 -0.4 6.72e-14 Height; CRC cis rs1971762 0.527 rs4019971 chr12:53978715 A/G cg06632207 chr12:54070931 ATP5G2 0.39 6.47 0.34 3.47e-10 Height; CRC cis rs6445967 1.000 rs1913715 chr3:58308214 G/A cg23715586 chr3:58305044 RPP14 0.36 6.01 0.31 4.81e-9 Platelet count; CRC cis rs4727027 0.866 rs35599790 chr7:148806012 C/T cg12479418 chr7:148823350 ZNF425;ZNF398 0.47 6.32 0.33 8.33e-10 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC cis rs6089584 0.893 rs6089306 chr20:60574868 G/A cg23262073 chr20:60523788 NA -0.42 -7.25 -0.37 2.99e-12 Body mass index; CRC cis rs10504229 0.683 rs17194995 chr8:58109220 A/C cg24829409 chr8:58192753 C8orf71 0.6 7.7 0.39 1.64e-13 Developmental language disorder (linguistic errors); CRC cis rs10504229 0.728 rs55812114 chr8:58157453 C/T cg20607798 chr8:58055168 NA 0.46 5.69 0.3 2.79e-8 Developmental language disorder (linguistic errors); CRC cis rs798554 0.836 rs798500 chr7:2790685 C/T cg14895029 chr7:2775587 GNA12 0.47 7.0 0.36 1.48e-11 Height; CRC cis rs9926296 0.585 rs6500441 chr16:89828669 C/G cg27121462 chr16:89883253 FANCA 0.37 5.66 0.3 3.37e-8 Vitiligo; CRC cis rs3736485 0.966 rs4144941 chr15:51796806 A/G cg08986416 chr15:51914746 DMXL2 -0.46 -6.45 -0.34 3.88e-10 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs6429082 0.521 rs704711 chr1:235629802 G/A cg26050004 chr1:235667680 B3GALNT2 0.75 12.54 0.57 9.07e-30 Adiposity; CRC cis rs9399135 0.967 rs7750300 chr6:135350950 C/G cg24558204 chr6:135376177 HBS1L 0.52 8.14 0.41 8.47e-15 Red blood cell count; CRC cis rs10504229 0.683 rs56211106 chr8:58113497 A/G cg02290350 chr8:58132656 NA -0.58 -8.24 -0.41 4.09e-15 Developmental language disorder (linguistic errors); CRC cis rs965469 0.947 rs6051773 chr20:3330382 C/G cg25506879 chr20:3388711 C20orf194 -0.39 -5.81 -0.31 1.44e-8 IFN-related cytopenia; CRC cis rs17270561 0.609 rs12203927 chr6:25732690 A/G cg17691542 chr6:26056736 HIST1H1C 0.73 9.26 0.45 2.71e-18 Iron status biomarkers; CRC trans rs7615952 0.932 rs13086087 chr3:125646281 A/C cg02560186 chr11:3602584 NA -0.46 -6.18 -0.32 1.89e-9 Blood pressure (smoking interaction); CRC trans rs3733585 0.699 rs7435196 chr4:9967556 A/C cg26043149 chr18:55253948 FECH -0.47 -7.32 -0.37 1.9e-12 Cleft plate (environmental tobacco smoke interaction); CRC cis rs11148252 0.840 rs3886077 chr13:52949053 C/A cg00495681 chr13:53174319 NA 0.59 9.0 0.44 1.9e-17 Lewy body disease; CRC cis rs10106298 0.846 rs1550005 chr8:103681662 C/G cg10187029 chr8:103597600 NA 0.42 5.87 0.31 1.05e-8 Schizophrenia; CRC cis rs875971 0.862 rs801194 chr7:66028495 T/C cg00343986 chr7:65444356 GUSB -0.45 -6.23 -0.33 1.39e-9 Aortic root size; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg10694539 chr12:42538536 GXYLT1 0.41 6.22 0.32 1.5e-9 Response to antipsychotic treatment; CRC cis rs59918340 0.764 rs9324542 chr8:142227854 A/T cg23750338 chr8:142222470 SLC45A4 -0.58 -10.82 -0.51 1.57e-23 Immature fraction of reticulocytes; CRC cis rs1129187 1.000 rs1129187 chr6:42932200 G/T cg10862848 chr6:42927986 GNMT -0.38 -8.85 -0.44 5.34e-17 Alzheimer's disease in APOE e4+ carriers; CRC cis rs17376456 0.877 rs28575883 chr5:93346035 T/C cg09848695 chr5:92956644 FAM172A;MIR2277 0.64 5.73 0.3 2.21e-8 Diabetic retinopathy; CRC cis rs7731657 0.537 rs1074840 chr5:130251717 A/G cg08523029 chr5:130500466 HINT1 -0.43 -5.84 -0.31 1.27e-8 Fasting plasma glucose; CRC cis rs2806561 0.929 rs641452 chr1:23538386 A/G cg19743168 chr1:23544995 NA 0.38 6.02 0.32 4.54e-9 Height; CRC cis rs6502050 0.835 rs35131307 chr17:80128439 G/A cg25804541 chr17:80189381 SLC16A3 -0.3 -5.84 -0.31 1.23e-8 Life satisfaction; CRC trans rs17685 0.712 rs10235086 chr7:75833138 G/T cg19862616 chr7:65841803 NCRNA00174 0.96 16.79 0.68 3.77e-46 Coffee consumption;Coffee consumption (cups per day); CRC cis rs4466137 0.830 rs10039752 chr5:82974532 G/A cg16102102 chr5:83017553 HAPLN1 -0.42 -6.27 -0.33 1.11e-9 Prostate cancer; CRC trans rs1455244 0.700 rs7229302 chr18:11508904 G/T cg23465967 chr2:111435611 BUB1 0.41 6.26 0.33 1.21e-9 Schizophrenia; CRC cis rs7552404 0.727 rs6683437 chr1:76316619 G/A cg22875332 chr1:76189707 ACADM 0.56 7.09 0.36 8.46e-12 Blood metabolite levels;Acylcarnitine levels; CRC cis rs9399135 0.933 rs28384512 chr6:135376232 C/T cg22676075 chr6:135203613 NA 0.38 5.88 0.31 1.01e-8 Red blood cell count; CRC cis rs6546550 0.743 rs6731941 chr2:70018496 A/G cg02498382 chr2:70120550 SNRNP27 -0.43 -7.04 -0.36 1.15e-11 Prevalent atrial fibrillation; CRC trans rs1908814 0.516 rs35391955 chr8:11796728 A/C cg08975724 chr8:8085496 FLJ10661 0.41 6.16 0.32 2.18e-9 Neuroticism; CRC cis rs7772486 0.817 rs12198065 chr6:146385286 G/C cg23711669 chr6:146136114 FBXO30 0.69 12.05 0.55 5.97e-28 Lobe attachment (rater-scored or self-reported); CRC cis rs2976388 0.647 rs2082801 chr8:143786461 A/G cg05569086 chr8:143859399 LYNX1 0.38 6.69 0.35 9.43e-11 Urinary tract infection frequency; CRC cis rs7940866 0.740 rs2162060 chr11:130830763 A/G cg12179176 chr11:130786555 SNX19 0.63 9.13 0.45 7.11e-18 Schizophrenia; CRC cis rs2032447 0.898 rs807205 chr6:26075035 C/G cg03517284 chr6:25882590 NA -0.48 -6.58 -0.34 1.89e-10 Intelligence (multi-trait analysis); CRC trans rs8002861 0.905 rs12429722 chr13:44412466 T/A cg17145862 chr1:211918768 LPGAT1 -0.68 -12.3 -0.56 7.55e-29 Leprosy; CRC cis rs7914558 0.966 rs10883817 chr10:104755431 C/T cg04362960 chr10:104952993 NT5C2 0.6 9.0 0.44 1.88e-17 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs6942756 0.774 rs2566885 chr7:128917587 C/T cg02491457 chr7:128862824 NA 0.66 9.21 0.45 3.9e-18 White matter hyperintensity burden; CRC cis rs875971 0.508 rs10950045 chr7:66066373 T/C cg00343986 chr7:65444356 GUSB -0.48 -7.11 -0.36 7.48e-12 Aortic root size; CRC cis rs9325144 0.624 rs10783330 chr12:39114084 A/G cg26384229 chr12:38710491 ALG10B -0.47 -6.76 -0.35 6.21e-11 Morning vs. evening chronotype; CRC trans rs61931739 0.553 rs68124042 chr12:34064431 C/A cg26384229 chr12:38710491 ALG10B 0.54 6.86 0.35 3.41e-11 Morning vs. evening chronotype; CRC cis rs4919694 1.000 rs11191439 chr10:104638723 C/T cg15744005 chr10:104629667 AS3MT 0.47 5.8 0.3 1.54e-8 Arsenic metabolism; CRC cis rs6540559 0.673 rs6698154 chr1:210007777 A/G cg22029157 chr1:209979665 IRF6 0.67 7.69 0.39 1.77e-13 Cleft lip with or without cleft palate; CRC cis rs1555322 0.530 rs7004 chr20:33866753 G/C cg13662093 chr20:33865505 NA 0.51 6.61 0.34 1.59e-10 Attention deficit hyperactivity disorder; CRC cis rs9311474 0.581 rs4687626 chr3:52569098 G/A cg18404041 chr3:52824283 ITIH1 -0.35 -7.29 -0.37 2.3e-12 Electroencephalogram traits; CRC cis rs3996993 0.509 rs11752938 chr6:52675433 C/T cg20803780 chr6:52668592 GSTA1 0.39 6.58 0.34 1.89e-10 Hemoglobin concentration; CRC cis rs9467711 0.591 rs9467622 chr6:25854644 C/A cg08501292 chr6:25962987 TRIM38 1.15 9.94 0.48 1.63e-20 Autism spectrum disorder or schizophrenia; CRC cis rs1552244 1.000 rs7611218 chr3:10063960 T/C cg13047869 chr3:10149882 C3orf24 0.51 7.07 0.36 9.31e-12 Alzheimer's disease; CRC cis rs7772486 0.655 rs2142981 chr6:146071695 G/C cg23711669 chr6:146136114 FBXO30 -0.74 -12.57 -0.57 7.4e-30 Lobe attachment (rater-scored or self-reported); CRC cis rs12824058 0.831 rs7485200 chr12:130811641 C/T cg26677194 chr12:130822605 PIWIL1 0.43 6.86 0.35 3.38e-11 Menopause (age at onset); CRC cis rs9902453 0.817 rs4794861 chr17:28183174 A/C cg26525008 chr17:28256777 EFCAB5;SSH2 0.59 8.95 0.44 2.66e-17 Coffee consumption (cups per day); CRC cis rs9611565 0.694 rs79011 chr22:41866938 A/G cg06481639 chr22:41940642 POLR3H 0.53 6.57 0.34 1.98e-10 Vitiligo; CRC cis rs7412746 0.588 rs10305664 chr1:150839686 A/C cg15448220 chr1:150897856 SETDB1 0.55 7.71 0.39 1.47e-13 Melanoma; CRC cis rs60871478 0.578 rs62432900 chr7:826794 G/C cg13844804 chr7:814759 HEATR2 0.68 8.0 0.4 2.15e-14 Cerebrospinal P-tau181p levels; CRC cis rs9311474 0.502 rs4687624 chr3:52563572 C/T cg18404041 chr3:52824283 ITIH1 -0.36 -7.36 -0.38 1.47e-12 Electroencephalogram traits; CRC cis rs6502050 0.764 rs35713597 chr17:80119016 C/G cg22110888 chr17:80059540 CCDC57 0.4 6.38 0.33 5.96e-10 Life satisfaction; CRC cis rs10504229 1.000 rs73609747 chr8:58189104 G/C cg02725872 chr8:58115012 NA -0.38 -6.43 -0.33 4.44e-10 Developmental language disorder (linguistic errors); CRC cis rs4654899 0.796 rs61779135 chr1:21532625 G/A cg02927042 chr1:21476669 EIF4G3 -0.51 -7.96 -0.4 2.73e-14 Superior frontal gyrus grey matter volume; CRC cis rs40363 0.672 rs1617722 chr16:3520806 C/T cg21433313 chr16:3507492 NAT15 -0.59 -8.54 -0.43 4.97e-16 Tuberculosis; CRC cis rs394563 0.781 rs61516098 chr6:149794289 A/T cg16235748 chr6:149772707 ZC3H12D -0.38 -6.52 -0.34 2.6e-10 Dupuytren's disease; CRC cis rs853679 0.517 rs9380049 chr6:28048535 A/G cg25164649 chr6:28176230 NA 0.72 9.1 0.45 9.16e-18 Depression; CRC cis rs10744422 1.000 rs936083 chr12:123338964 A/G cg25930673 chr12:123319894 HIP1R -0.61 -6.4 -0.33 5.25e-10 Schizophrenia; CRC cis rs873946 0.564 rs12263364 chr10:134555548 G/T cg18305652 chr10:134549665 INPP5A 0.52 7.38 0.38 1.33e-12 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CRC cis rs4689592 0.619 rs2359011 chr4:7066052 T/G cg26116260 chr4:7069785 GRPEL1 0.98 14.91 0.64 8.86e-39 Monocyte percentage of white cells; CRC cis rs1401999 0.966 rs2037379 chr3:183650330 T/C cg01324343 chr3:183735012 ABCC5 0.81 14.53 0.63 2.62e-37 Anterior chamber depth; CRC cis rs7605827 0.930 rs12995776 chr2:15717131 T/A cg19274914 chr2:15703543 NA 0.38 5.88 0.31 1.01e-8 Educational attainment (years of education); CRC cis rs6866614 0.608 rs17132288 chr5:131336105 C/T cg12564285 chr5:131593104 PDLIM4 0.34 6.17 0.32 2.05e-9 Perceived unattractiveness to mosquitoes; CRC cis rs7917772 0.636 rs4919674 chr10:104522226 T/C cg11453585 chr10:104263688 ACTR1A;SUFU -0.69 -10.28 -0.49 1.15e-21 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC cis rs9787249 0.957 rs7547787 chr1:40220806 C/T cg02773041 chr1:40204384 PPIE 0.62 9.23 0.45 3.45e-18 Blood protein levels; CRC cis rs7618915 0.533 rs35107891 chr3:52613656 G/C cg11645453 chr3:52864694 ITIH4 0.35 6.11 0.32 2.81e-9 Bipolar disorder; CRC cis rs2286885 0.965 rs10987301 chr9:129250688 T/C cg15282417 chr9:129245246 FAM125B -0.46 -8.68 -0.43 1.85e-16 Intraocular pressure; CRC cis rs6500602 0.623 rs9929311 chr16:4510426 T/C cg06139259 chr16:4526053 HMOX2;NMRAL1 0.56 7.37 0.38 1.39e-12 Schizophrenia; CRC trans rs66573146 0.831 rs6832482 chr4:7023433 A/T cg07817883 chr1:32538562 TMEM39B 1.13 10.37 0.5 5.44e-22 Granulocyte percentage of myeloid white cells; CRC cis rs7615952 0.599 rs7652883 chr3:125707977 T/G cg18479299 chr3:125709523 NA -0.52 -6.31 -0.33 9.06e-10 Blood pressure (smoking interaction); CRC cis rs9942416 0.660 rs67803720 chr5:74984408 A/T cg00601450 chr5:74908170 NA 0.42 5.96 0.31 6.59e-9 Age-related disease endophenotypes; CRC cis rs6540559 0.673 rs17015183 chr1:209948711 A/C cg21951975 chr1:209979733 IRF6 0.5 6.76 0.35 6.12e-11 Cleft lip with or without cleft palate; CRC cis rs9658691 1.000 rs9658691 chr10:90756163 T/C cg03111039 chr10:90751583 FAS;ACTA2 -0.94 -6.66 -0.34 1.16e-10 Mosquito bite size; CRC cis rs6860806 0.507 rs635620 chr5:131720263 A/G cg27615366 chr5:131592974 PDLIM4 -0.32 -5.64 -0.3 3.75e-8 Breast cancer; CRC cis rs12541635 1.000 rs12541635 chr8:107090000 C/T cg10147462 chr8:107024639 NA -0.37 -6.22 -0.32 1.52e-9 Age of smoking initiation; CRC cis rs968567 0.539 rs174555 chr11:61579760 T/C cg06781209 chr11:61594997 FADS2 -0.42 -5.99 -0.31 5.58e-9 Blood metabolite levels;Rheumatoid arthritis;Vitiligo;Glycerophospholipid levels; CRC cis rs523522 0.962 rs4767912 chr12:120981202 A/G cg27279351 chr12:120934652 DYNLL1 0.77 11.31 0.53 2.78e-25 High light scatter reticulocyte count; CRC cis rs9399135 0.660 rs4267967 chr6:135272477 T/G cg24558204 chr6:135376177 HBS1L 0.54 8.2 0.41 5.56e-15 Red blood cell count; CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg05241839 chr16:53537463 AKTIP 0.39 6.21 0.32 1.57e-9 Obesity-related traits; CRC trans rs1933755 0.541 rs61479838 chr6:130920921 T/C cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.92 -6.72 -0.35 7.93e-11 Colorectal cancer (calcium intake interaction); CRC cis rs11711311 0.955 rs12630791 chr3:113387717 C/T cg06805542 chr3:113465803 ATP6V1A;NAA50 0.5 6.74 0.35 7.22e-11 IgG glycosylation; CRC cis rs1552244 0.882 rs17050660 chr3:10001772 A/G cg08888203 chr3:10149979 C3orf24 -0.64 -8.71 -0.43 1.46e-16 Alzheimer's disease; CRC cis rs6964587 0.934 rs4512319 chr7:91733829 G/A cg03714773 chr7:91764589 CYP51A1 0.35 5.81 0.31 1.45e-8 Breast cancer; CRC cis rs651907 0.557 rs59596156 chr3:101394217 C/T cg11279151 chr3:101281821 RG9MTD1 -0.51 -6.79 -0.35 5.24e-11 Colorectal cancer; CRC cis rs9467711 0.790 rs35162296 chr6:26318262 C/T cg16898833 chr6:26189333 HIST1H4D 0.99 7.54 0.38 4.65e-13 Autism spectrum disorder or schizophrenia; CRC cis rs853679 0.527 rs9468333 chr6:28271198 C/T cg21251018 chr6:28226885 NKAPL 0.53 8.76 0.43 1.04e-16 Depression; CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg05994458 chr11:13484274 BTBD10 -0.53 -6.27 -0.33 1.15e-9 Diisocyanate-induced asthma; CRC cis rs7726839 0.561 rs72703044 chr5:579737 G/A cg14541582 chr5:601475 NA -0.32 -6.61 -0.34 1.57e-10 Obesity-related traits; CRC cis rs7618501 0.603 rs72942333 chr3:49986118 T/C cg24308560 chr3:49941425 MST1R -0.51 -8.26 -0.41 3.52e-15 Intelligence (multi-trait analysis); CRC cis rs7937682 0.737 rs542275 chr11:111431614 C/T cg22437258 chr11:111473054 SIK2 0.36 5.63 0.3 3.93e-8 Primary sclerosing cholangitis; CRC cis rs13108904 0.967 rs1732107 chr4:1276758 G/A cg21620606 chr4:1342894 KIAA1530 -0.34 -5.81 -0.31 1.47e-8 Obesity-related traits; CRC cis rs10486722 0.606 rs1990133 chr7:41800176 C/T cg22138096 chr7:41772439 LOC285954 0.44 5.67 0.3 3.12e-8 Pit-and-Fissure caries; CRC cis rs9303401 0.614 rs34678056 chr17:57177549 G/A cg02118635 chr17:56770003 RAD51C;TEX14 0.68 8.42 0.42 1.15e-15 Cognitive test performance; CRC trans rs7618501 0.966 rs13085679 chr3:49869631 G/A cg21659725 chr3:3221576 CRBN 0.89 16.61 0.68 2.11e-45 Intelligence (multi-trait analysis); CRC trans rs3931020 0.720 rs927904 chr1:75260328 A/G cg17860133 chr12:117468345 FBXW8 -0.48 -6.21 -0.32 1.61e-9 Resistin levels; CRC trans rs11098499 0.955 rs13114751 chr4:120156617 G/A cg25214090 chr10:38739885 LOC399744 0.5 7.73 0.39 1.29e-13 Corneal astigmatism; CRC cis rs6570726 0.870 rs370653 chr6:145823642 G/A cg05347473 chr6:146136440 FBXO30 0.37 6.0 0.31 5.27e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs2976388 0.609 rs2263092 chr8:143789966 A/G cg15511327 chr8:143859410 LYNX1 0.42 7.45 0.38 8.2e-13 Urinary tract infection frequency; CRC cis rs898097 0.627 rs3785514 chr17:80888905 A/G cg16060761 chr17:80687452 NA -0.44 -6.33 -0.33 8.21e-10 Breast cancer; CRC trans rs10983614 1.000 rs7867776 chr9:120072627 A/G cg25730138 chr19:5903868 NDUFA11;VMAC 0.45 6.09 0.32 3.08e-9 Survival in pancreatic cancer; CRC cis rs28830936 1.000 rs4923905 chr15:41909889 G/A cg17847044 chr15:42102381 MAPKBP1 -0.29 -6.1 -0.32 2.9e-9 Diastolic blood pressure; CRC cis rs6696846 0.765 rs61822619 chr1:205090885 C/G cg03948781 chr1:205179583 DSTYK 0.43 6.13 0.32 2.56e-9 Red blood cell count; CRC cis rs2952156 0.876 rs903501 chr17:37839493 T/C cg11212589 chr17:38028394 ZPBP2 0.34 5.77 0.3 1.81e-8 Asthma; CRC trans rs7829975 0.742 rs12547493 chr8:8661534 C/T cg16141378 chr3:129829833 LOC729375 0.42 6.15 0.32 2.2e-9 Mood instability; CRC cis rs2072499 0.966 rs6427304 chr1:156156789 A/G cg25208724 chr1:156163844 SLC25A44 1.07 24.43 0.8 6.45e-76 Testicular germ cell tumor; CRC cis rs2692947 0.644 rs1168975 chr2:96814075 G/A cg23100626 chr2:96804247 ASTL 0.31 7.98 0.4 2.49e-14 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; CRC cis rs6502050 0.835 rs35131307 chr17:80128439 G/A cg22110888 chr17:80059540 CCDC57 0.4 6.43 0.33 4.37e-10 Life satisfaction; CRC cis rs3733585 0.699 rs7435196 chr4:9967556 A/C cg00071950 chr4:10020882 SLC2A9 -0.55 -9.98 -0.48 1.12e-20 Cleft plate (environmental tobacco smoke interaction); CRC cis rs62103177 0.733 rs62096748 chr18:77619699 T/C cg00383167 chr18:77616694 NA 0.54 5.99 0.31 5.51e-9 Opioid sensitivity; CRC cis rs11212617 1.000 rs228598 chr11:108107497 T/G cg12106634 chr11:108092400 ATM;NPAT 0.43 6.34 0.33 7.36e-10 Response to metformin in type 2 diabetes (glycemic); CRC trans rs6951245 0.938 rs112425403 chr7:1071531 A/G cg13565492 chr6:43139072 SRF -0.7 -7.21 -0.37 3.78e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs910316 0.737 rs175071 chr14:75498177 A/G cg08847533 chr14:75593920 NEK9 -0.82 -14.69 -0.63 6.5e-38 Height; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg24082730 chr3:126076366 KLF15 0.45 6.19 0.32 1.83e-9 Anxiety disorder; CRC cis rs798554 0.797 rs1182174 chr7:2875420 G/A cg19346786 chr7:2764209 NA -0.43 -7.42 -0.38 9.91e-13 Height; CRC cis rs6598955 0.724 rs12757113 chr1:26597144 C/T cg00852783 chr1:26633632 UBXN11 0.42 6.76 0.35 6.45e-11 Obesity-related traits; CRC trans rs11088226 0.681 rs2409456 chr21:33929374 G/A cg09050820 chr6:167586206 TCP10L2 0.83 8.98 0.44 2.11e-17 Gastritis; CRC cis rs77633900 0.772 rs2460161 chr15:76640430 C/T cg21673338 chr15:77095150 SCAPER -0.72 -6.32 -0.33 8.48e-10 Non-glioblastoma glioma;Glioma; CRC cis rs875971 0.862 rs937494 chr7:65764678 T/A cg11764359 chr7:65958608 NA -0.61 -9.36 -0.46 1.28e-18 Aortic root size; CRC trans rs11098499 0.955 rs6815725 chr4:120158410 C/A cg25214090 chr10:38739885 LOC399744 0.52 8.1 0.41 1.05e-14 Corneal astigmatism; CRC trans rs8002861 0.810 rs7334812 chr13:44445538 C/T cg17145862 chr1:211918768 LPGAT1 0.71 14.1 0.61 1.25e-35 Leprosy; CRC cis rs72615157 0.634 rs11762932 chr7:99792666 C/T cg07160278 chr7:100027354 MEPCE;ZCWPW1 -0.73 -8.86 -0.44 5.13e-17 Lung function (FEV1/FVC); CRC cis rs3858526 0.642 rs10838783 chr11:5900282 T/G cg05234568 chr11:5960015 NA -0.55 -7.57 -0.39 3.67e-13 DNA methylation (variation); CRC cis rs1218582 0.804 rs4845398 chr1:154859038 G/C cg03351412 chr1:154909251 PMVK 0.54 8.6 0.43 3.27e-16 Prostate cancer; CRC cis rs9303280 0.806 rs11078927 chr17:38064405 C/T cg00129232 chr17:37814104 STARD3 -0.48 -7.67 -0.39 1.9e-13 Self-reported allergy; CRC cis rs9322193 0.884 rs1125 chr6:149979416 G/A cg07701084 chr6:150067640 NUP43 0.56 7.75 0.39 1.14e-13 Lung cancer; CRC cis rs5769765 0.818 rs138850 chr22:50193337 C/T cg22709217 chr22:50311962 ALG12;CRELD2 0.8 12.26 0.56 1.02e-28 Schizophrenia; CRC cis rs34172651 0.517 rs2547040 chr16:24736408 G/C cg02428538 chr16:24856791 SLC5A11 0.57 6.8 0.35 4.96e-11 Intelligence (multi-trait analysis); CRC cis rs651907 0.557 rs34947019 chr3:101532235 C/T cg11279151 chr3:101281821 RG9MTD1 -0.52 -6.88 -0.35 3.03e-11 Colorectal cancer; CRC cis rs9322193 0.962 rs4869731 chr6:150131208 T/C cg05861140 chr6:150128134 PCMT1 -0.43 -7.01 -0.36 1.39e-11 Lung cancer; CRC cis rs763121 0.853 rs6519120 chr22:38991393 A/C cg06022373 chr22:39101656 GTPBP1 -0.77 -11.67 -0.54 1.44e-26 Menopause (age at onset); CRC cis rs1552244 1.000 rs6804473 chr3:10060425 C/T cg02579736 chr3:10068473 FANCD2;CIDECP 0.96 12.63 0.57 4.41e-30 Alzheimer's disease; CRC cis rs10504229 1.000 rs77120900 chr8:58170368 C/T cg05313129 chr8:58192883 C8orf71 -0.47 -6.99 -0.36 1.49e-11 Developmental language disorder (linguistic errors); CRC cis rs7845219 0.544 rs7016078 chr8:95922615 G/A cg16049864 chr8:95962084 TP53INP1 -0.44 -6.78 -0.35 5.72e-11 Type 2 diabetes; CRC cis rs9902453 0.769 rs7210288 chr17:28243473 T/G cg26525008 chr17:28256777 EFCAB5;SSH2 0.58 8.74 0.43 1.21e-16 Coffee consumption (cups per day); CRC cis rs3768617 0.510 rs4651142 chr1:183097386 A/T ch.1.3577855R chr1:183094577 LAMC1 0.88 15.3 0.64 2.7e-40 Fuchs's corneal dystrophy; CRC cis rs938554 0.612 rs7669607 chr4:9997801 C/T cg11266682 chr4:10021025 SLC2A9 -0.38 -5.95 -0.31 7.03e-9 Blood metabolite levels; CRC cis rs9488822 0.676 rs1556857 chr6:116325559 T/C cg05304507 chr6:116381966 FRK 0.3 8.24 0.41 4.08e-15 Cholesterol, total;LDL cholesterol; CRC cis rs2115630 0.846 rs8024538 chr15:85368419 A/T cg17507749 chr15:85114479 UBE2QP1 -0.41 -6.08 -0.32 3.26e-9 P wave terminal force; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg19379625 chr4:71859087 DCK 0.49 6.25 0.33 1.31e-9 Thyroid stimulating hormone; CRC cis rs4880487 1.000 rs4880487 chr10:1246883 C/T cg03183215 chr10:1252341 ADARB2 -0.31 -6.52 -0.34 2.65e-10 Migraine; CRC cis rs6662572 0.737 rs72677550 chr1:46589276 G/C cg03123370 chr1:45965343 CCDC163P;MMACHC 0.47 5.96 0.31 6.43e-9 Blood protein levels; CRC cis rs2179367 0.959 rs544947 chr6:149723548 A/G cg11245181 chr6:149772854 ZC3H12D -0.4 -6.02 -0.31 4.68e-9 Dupuytren's disease; CRC cis rs5750830 0.649 rs4337572 chr22:39800704 C/G cg24399712 chr22:39784796 NA -0.53 -11.11 -0.52 1.49e-24 Intelligence (multi-trait analysis); CRC cis rs10751667 0.666 rs4074235 chr11:977511 C/G cg06064525 chr11:970664 AP2A2 -0.3 -6.11 -0.32 2.78e-9 Alzheimer's disease (late onset); CRC cis rs3823572 0.564 rs2346273 chr7:133659764 A/T cg03336402 chr7:133662267 EXOC4 -0.67 -10.62 -0.51 7.59e-23 Intelligence (multi-trait analysis); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T ch.8.34907260F chr8:34787718 NA 0.41 6.01 0.31 4.96e-9 Intelligence (multi-trait analysis); CRC cis rs7943191 0.810 rs7942154 chr11:62337163 G/A cg11742103 chr11:62369870 EML3;MTA2 0.58 9.75 0.47 6.51e-20 Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction); CRC cis rs13118159 0.550 rs4974617 chr4:1373658 T/C cg02018176 chr4:1364513 KIAA1530 0.71 12.1 0.56 3.89e-28 Longevity; CRC trans rs6544773 0.526 rs191468 chr2:45063290 G/A cg10208897 chr5:178548229 ADAMTS2 0.35 6.18 0.32 1.86e-9 Mosquito bite size; CRC cis rs6700896 0.931 rs59508186 chr1:66107881 C/A cg04111102 chr1:66153794 NA 0.32 5.68 0.3 3e-8 C-reactive protein;Mean corpuscular volume;Mean corpuscular hemoglobin; CRC cis rs344364 0.529 rs186941 chr16:1930088 T/C cg09830162 chr16:1889614 FAHD1;C16orf73 0.77 9.66 0.47 1.39e-19 Glomerular filtration rate in chronic kidney disease; CRC cis rs59104589 0.617 rs56663202 chr2:242262311 A/G cg19488206 chr2:242435732 STK25 0.46 6.53 0.34 2.44e-10 Fibrinogen levels; CRC cis rs6773854 0.526 rs2253944 chr3:187643346 C/T cg10168494 chr3:187635183 NA -0.46 -7.5 -0.38 5.93e-13 B cell non-Hodgkin lymphoma; CRC trans rs1656966 1.000 rs1656966 chr3:186466252 C/T cg13623690 chr16:84651800 COTL1 0.43 6.5 0.34 3.06e-10 Myopia (pathological); CRC cis rs2228479 0.850 rs11641552 chr16:89838700 C/A cg06558623 chr16:89946397 TCF25 1.13 10.76 0.51 2.47e-23 Skin colour saturation; CRC cis rs933688 1.000 rs889213 chr5:90682151 C/T cg02339078 chr5:90679543 LOC100129716;ARRDC3 0.92 13.87 0.61 9.28e-35 Smoking behavior; CRC trans rs2303319 0.504 rs62189053 chr2:162624324 G/A cg23919916 chr10:103825097 HPS6 -0.69 -5.99 -0.31 5.54e-9 Cognitive function; CRC trans rs1656966 1.000 rs1656966 chr3:186466252 C/T cg09974566 chr22:32150118 DEPDC5 0.44 6.63 0.34 1.36e-10 Myopia (pathological); CRC cis rs10992471 0.639 rs10125587 chr9:95499882 G/A cg14631576 chr9:95140430 CENPP -0.38 -6.76 -0.35 6.3e-11 Visceral adipose tissue/subcutaneous adipose tissue ratio; CRC cis rs8177253 0.606 rs6787177 chr3:133450720 C/T cg17775713 chr3:133465469 TF 0.34 6.04 0.32 4.07e-9 Iron status biomarkers; CRC cis rs34421088 0.576 rs2572437 chr8:11098441 C/T cg27411982 chr8:10470053 RP1L1 -0.38 -5.64 -0.3 3.75e-8 Neuroticism; CRC cis rs208520 1.000 rs72882102 chr6:66983408 C/A cg07460842 chr6:66804631 NA 0.91 11.17 0.52 8.75e-25 Exhaled nitric oxide output; CRC cis rs796364 0.806 rs74938253 chr2:201008386 T/G cg23649088 chr2:200775458 C2orf69 -0.58 -5.91 -0.31 8.54e-9 Schizophrenia; CRC cis rs4664293 0.647 rs7575924 chr2:160429560 C/G cg08347373 chr2:160653686 CD302 -0.38 -6.43 -0.33 4.52e-10 Monocyte percentage of white cells; CRC cis rs2303759 1.000 rs2303759 chr19:49869051 T/G cg24324837 chr19:49891574 CCDC155 0.59 8.43 0.42 1.12e-15 Multiple sclerosis; CRC cis rs2204008 0.624 rs2320449 chr12:38224190 T/C cg26384229 chr12:38710491 ALG10B 0.69 9.26 0.45 2.81e-18 Bladder cancer; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg04559178 chr12:29301719 NA 0.49 6.98 0.36 1.64e-11 Response to antipsychotic treatment; CRC cis rs863345 0.604 rs7514968 chr1:158493852 A/T cg12129480 chr1:158549410 OR10X1 -0.29 -5.95 -0.31 7e-9 Pneumococcal bacteremia; CRC cis rs6500395 1.000 rs7198773 chr16:48606091 T/C cg04672837 chr16:48644449 N4BP1 0.44 6.5 0.34 2.95e-10 Response to tocilizumab in rheumatoid arthritis; CRC cis rs6463523 0.933 rs4724821 chr7:762544 C/T cg06242242 chr7:766104 PRKAR1B;HEATR2 0.91 15.68 0.65 8.83e-42 Subjective well-being; CRC cis rs939658 0.683 rs1434459 chr15:79465210 T/C cg17916960 chr15:79447300 NA -0.44 -7.02 -0.36 1.3e-11 Refractive error; CRC cis rs148734725 1 rs148734725 chr3:49406708 G/A cg00383909 chr3:49044727 WDR6 0.43 5.65 0.3 3.45e-8 Educational attainment (college completion); CRC cis rs9902453 0.808 rs78154346 chr17:28169493 C/T cg26525008 chr17:28256777 EFCAB5;SSH2 0.59 8.8 0.44 7.81e-17 Coffee consumption (cups per day); CRC cis rs1552244 0.572 rs57268864 chr3:10164233 C/A cg13047869 chr3:10149882 C3orf24 0.54 6.49 0.34 3.1e-10 Alzheimer's disease; CRC cis rs9303401 0.659 rs12600349 chr17:57054245 A/G cg02118635 chr17:56770003 RAD51C;TEX14 -0.8 -10.08 -0.49 5.35e-21 Cognitive test performance; CRC cis rs12216125 0.554 rs6942196 chr6:26072804 A/G cg18357526 chr6:26021779 HIST1H4A 0.43 6.06 0.32 3.81e-9 Iron status biomarkers; CRC cis rs7811142 1.000 rs1000215 chr7:100004543 A/G cg00814883 chr7:100076585 TSC22D4 -0.7 -9.08 -0.45 1.02e-17 Platelet count; CRC cis rs739401 0.611 rs12284275 chr11:3024384 T/C cg05729581 chr11:3078854 CARS -0.59 -8.72 -0.43 1.4e-16 Longevity; CRC cis rs6701037 1.000 rs6425323 chr1:175125036 C/T cg00321850 chr1:175162397 KIAA0040 -0.36 -5.9 -0.31 8.95e-9 Alcohol dependence; CRC cis rs12477438 0.501 rs11683107 chr2:99759235 T/A cg26064155 chr2:99771622 LIPT1;TSGA10 0.78 13.38 0.59 6.83e-33 Chronic sinus infection; CRC cis rs9911578 1.000 rs11869828 chr17:56609525 G/A cg05425664 chr17:57184151 TRIM37 0.51 8.17 0.41 6.81e-15 Intelligence (multi-trait analysis); CRC cis rs2180341 0.814 rs6914131 chr6:127737489 T/C cg24812749 chr6:127587940 RNF146 0.67 9.1 0.45 9.08e-18 Breast cancer; CRC cis rs9549328 0.756 rs2993291 chr13:113653846 C/T cg08614441 chr13:113633676 MCF2L -0.47 -7.39 -0.38 1.24e-12 Systolic blood pressure; CRC cis rs25645 0.502 rs7223318 chr17:38108553 G/C cg17344932 chr17:38183730 MED24;SNORD124 -0.56 -8.86 -0.44 5.27e-17 Myeloid white cell count; CRC cis rs1707322 0.721 rs12045096 chr1:46114428 A/G cg06784218 chr1:46089804 CCDC17 0.65 12.17 0.56 2.14e-28 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs6460942 1.000 rs6948314 chr7:12418363 T/A cg06484146 chr7:12443880 VWDE -0.74 -8.45 -0.42 9.67e-16 Coronary artery disease; CRC cis rs425277 0.606 rs377283 chr1:2075570 T/C cg12639453 chr1:2035780 PRKCZ 0.32 5.87 0.31 1.07e-8 Height; CRC cis rs9462846 1.000 rs9462846 chr6:42861581 A/C cg10862848 chr6:42927986 GNMT -0.3 -5.64 -0.3 3.75e-8 Blood protein levels; CRC cis rs7927771 0.832 rs4752994 chr11:47411065 A/T cg05585544 chr11:47624801 NA 0.53 9.3 0.46 2.09e-18 Subjective well-being; CRC cis rs7772486 0.720 rs7752286 chr6:146072662 C/T cg05347473 chr6:146136440 FBXO30 -0.39 -5.86 -0.31 1.12e-8 Lobe attachment (rater-scored or self-reported); CRC cis rs17001868 0.568 rs2280790 chr22:40745181 T/C cg07138101 chr22:40742427 ADSL 0.56 7.15 0.37 5.71e-12 Mammographic density (dense area); CRC cis rs4563143 0.675 rs73029042 chr19:29267979 A/T cg03161606 chr19:29218774 NA 0.52 6.52 0.34 2.68e-10 Methadone dose in opioid dependence; CRC cis rs12477438 0.520 rs2516835 chr2:99779131 T/C cg14399236 chr2:99771627 LIPT1;TSGA10 0.73 12.17 0.56 2.24e-28 Chronic sinus infection; CRC cis rs898097 0.845 rs7213006 chr17:80899928 T/C cg19046167 chr17:80928561 B3GNTL1 0.38 5.95 0.31 6.75e-9 Breast cancer; CRC cis rs57590327 0.516 rs66665538 chr3:81796391 T/A cg07356753 chr3:81810745 GBE1 -0.61 -6.18 -0.32 1.91e-9 Extraversion; CRC cis rs8064454 0.764 rs11658063 chr17:36103872 C/G cg04198914 chr17:36106025 HNF1B 0.37 8.4 0.42 1.37e-15 Prostate cancer; CRC cis rs4074493 1.000 rs11122199 chr1:231172686 T/C cg22172038 chr1:231176991 FAM89A 0.35 6.03 0.32 4.29e-9 Carotid plaque burden (smoking interaction); CRC trans rs2018683 0.899 rs10479816 chr7:28978021 G/A cg19402173 chr7:128379420 CALU -0.57 -8.47 -0.42 8.54e-16 Response to irinotecan and platinum-based chemotherapy in non-small-cell lung cancer; CRC cis rs1008375 1.000 rs10032326 chr4:17630717 A/T cg04450456 chr4:17643702 FAM184B 0.36 5.75 0.3 2e-8 Parasitemia in Tripanosoma cruzi seropositivity; CRC trans rs4478147 0.636 rs6847139 chr4:87465741 G/A cg01215037 chr19:50083917 PRRG2;NOSIP 0.45 5.97 0.31 6.1e-9 Migraine - clinic-based; CRC cis rs11212617 0.805 rs10890821 chr11:108022061 A/T cg14761454 chr11:108092087 ATM;NPAT 0.45 6.74 0.35 7.22e-11 Response to metformin in type 2 diabetes (glycemic); CRC cis rs1799949 1.000 rs11654452 chr17:41189383 G/T cg01879757 chr17:41196368 BRCA1 -0.41 -6.06 -0.32 3.7e-9 Menopause (age at onset); CRC cis rs4713118 0.869 rs9461400 chr6:27700559 A/G cg06470822 chr6:28175283 NA 0.71 10.07 0.49 5.85e-21 Parkinson's disease; CRC cis rs2380220 0.574 rs7766765 chr6:95997362 G/A cg15832292 chr6:96025679 MANEA 0.56 6.29 0.33 1.03e-9 Behavioural disinhibition (generation interaction); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg00414561 chr15:23034473 NIPA2 0.4 6.49 0.34 3.19e-10 Liver disease severity in Alagille syndrome; CRC cis rs3785574 0.962 rs62077509 chr17:61848973 A/G cg25654072 chr17:61904446 PSMC5;FTSJ3 0.42 5.88 0.31 1.01e-8 Height; CRC cis rs2625529 0.689 rs2957742 chr15:72302894 C/G cg16672083 chr15:72433130 SENP8 0.48 7.41 0.38 1.1e-12 Red blood cell count; CRC cis rs2019137 0.539 rs6755040 chr2:113981137 T/C cg25243455 chr2:114033360 PAX8;LOC440839 -0.28 -6.66 -0.34 1.18e-10 Lymphocyte counts; CRC cis rs898097 0.627 rs3785514 chr17:80888905 A/G cg15664640 chr17:80829946 TBCD 0.64 10.01 0.48 9.44e-21 Breast cancer; CRC cis rs10504229 0.683 rs16921829 chr8:58110950 A/G cg24829409 chr8:58192753 C8orf71 -0.56 -8.02 -0.4 1.82e-14 Developmental language disorder (linguistic errors); CRC trans rs1005277 0.528 rs2057228 chr10:38515766 T/C cg17830980 chr10:43048298 ZNF37B -0.57 -9.68 -0.47 1.16e-19 Extrinsic epigenetic age acceleration; CRC cis rs1178968 0.901 rs4717752 chr7:72754237 A/T cg25889504 chr7:72793014 NA 0.48 5.71 0.3 2.57e-8 Triglyceride levels; CRC cis rs754466 0.580 rs1054608 chr10:79543308 T/G cg26805224 chr10:79626177 DLG5 -0.49 -7.25 -0.37 3.06e-12 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs6912958 0.874 rs2103764 chr6:88157392 T/A cg12350822 chr6:88032061 C6orf162;GJB7 -0.38 -7.21 -0.37 3.89e-12 Monocyte percentage of white cells; CRC trans rs12599106 0.839 rs3853177 chr16:34498532 A/G cg18110333 chr6:292329 DUSP22 -0.58 -8.29 -0.42 2.82e-15 Menopause (age at onset); CRC cis rs7959452 0.868 rs10784774 chr12:69737879 C/T cg14784868 chr12:69753453 YEATS4 -0.67 -10.47 -0.5 2.39e-22 Blood protein levels; CRC cis rs77686669 1 rs77686669 chr7:99744572 T/C cg07160278 chr7:100027354 MEPCE;ZCWPW1 0.45 5.85 0.31 1.2e-8 Venous thromboembolism adjusted for sickle cell variant rs77121243-T; CRC cis rs35306767 0.903 rs12762228 chr10:880854 G/A cg20503657 chr10:835505 NA 1.23 14.72 0.63 4.77e-38 Eosinophil percentage of granulocytes; CRC cis rs9457247 0.663 rs12526548 chr6:167431147 C/T cg07741184 chr6:167504864 NA 0.35 6.22 0.32 1.54e-9 Crohn's disease; CRC cis rs10504229 0.683 rs10504224 chr8:58143735 A/G cg08219700 chr8:58056026 NA 0.56 6.77 0.35 6e-11 Developmental language disorder (linguistic errors); CRC cis rs6840360 0.608 rs2724556 chr4:152341717 G/A cg09659197 chr4:152720779 NA 0.43 8.4 0.42 1.37e-15 Intelligence (multi-trait analysis); CRC cis rs56116382 0.605 rs12715435 chr3:49338992 G/A cg00383909 chr3:49044727 WDR6 0.68 7.02 0.36 1.26e-11 Intelligence (multi-trait analysis);High light scatter reticulocyte count; CRC cis rs9443645 0.901 rs9361480 chr6:79724429 C/T cg11833968 chr6:79620685 NA -0.34 -5.82 -0.31 1.39e-8 Intelligence (multi-trait analysis); CRC cis rs5753618 0.583 rs5753601 chr22:31798259 G/T cg07713946 chr22:31675144 LIMK2 0.42 6.28 0.33 1.07e-9 Colorectal cancer; CRC cis rs8141797 0.901 rs8140812 chr22:24553535 C/T cg20894457 chr22:24584366 SUSD2 0.62 7.64 0.39 2.37e-13 Amyotrophic lateral sclerosis;Coronary artery disease; CRC cis rs10504229 0.728 rs72650856 chr8:58152695 C/T cg24829409 chr8:58192753 C8orf71 -0.58 -7.96 -0.4 2.86e-14 Developmental language disorder (linguistic errors); CRC trans rs7824557 0.564 rs2572400 chr8:11234367 T/G cg06636001 chr8:8085503 FLJ10661 -0.47 -7.2 -0.37 4.21e-12 Retinal vascular caliber; CRC cis rs10504229 0.683 rs16921823 chr8:58108612 G/C cg21724239 chr8:58056113 NA 0.52 6.97 0.36 1.79e-11 Developmental language disorder (linguistic errors); CRC cis rs7552404 0.691 rs1770890 chr1:76401117 A/G cg03433033 chr1:76189801 ACADM -0.58 -7.43 -0.38 9.6e-13 Blood metabolite levels;Acylcarnitine levels; CRC cis rs9296092 0.538 rs62407564 chr6:33534010 C/T cg13560919 chr6:33536144 NA -0.43 -5.91 -0.31 8.33e-9 Age at smoking initiation in chronic obstructive pulmonary disease; CRC cis rs9916302 0.706 rs7212621 chr17:37527911 T/G cg00129232 chr17:37814104 STARD3 0.58 7.15 0.37 5.6e-12 Glomerular filtration rate (creatinine); CRC cis rs2760061 0.583 rs708123 chr1:228220495 A/G cg01200585 chr1:228362443 C1orf69 0.5 6.74 0.35 7.17e-11 Diastolic blood pressure; CRC cis rs10504229 0.683 rs17194487 chr8:58104912 C/T cg02290350 chr8:58132656 NA -0.59 -6.85 -0.35 3.68e-11 Developmental language disorder (linguistic errors); CRC cis rs428668 0.523 rs3926389 chr5:150677806 C/T cg11125805 chr5:150678162 SLC36A3 0.63 12.41 0.56 2.88e-29 Skin aging (microtopography measurement); CRC cis rs9611565 0.765 rs202663 chr22:41812819 T/C cg06481639 chr22:41940642 POLR3H 0.48 5.62 0.3 4.16e-8 Vitiligo; CRC cis rs10927875 0.518 rs1763597 chr1:16343297 C/T cg10494257 chr1:16342123 HSPB7 0.45 6.27 0.33 1.1e-9 Dilated cardiomyopathy; CRC cis rs1003719 0.680 rs2835621 chr21:38510616 G/A cg10648535 chr21:38446584 PIGP;TTC3 -0.48 -6.7 -0.35 8.99e-11 Eye color traits; CRC cis rs853679 0.723 rs1736904 chr6:28219270 G/A cg25164649 chr6:28176230 NA 0.55 6.45 0.34 3.99e-10 Depression; CRC cis rs2075371 0.897 rs1646743 chr7:134003451 C/A cg20476274 chr7:133979776 SLC35B4 0.72 12.22 0.56 1.39e-28 Mean platelet volume; CRC cis rs394563 0.622 rs237024 chr6:149721965 T/C cg07828024 chr6:149772892 ZC3H12D -0.53 -9.9 -0.48 2.13e-20 Dupuytren's disease; CRC cis rs8180040 0.620 rs11715121 chr3:47072621 T/A cg27129171 chr3:47204927 SETD2 -0.73 -11.46 -0.53 8.18e-26 Colorectal cancer; CRC cis rs11608355 0.846 rs4766471 chr12:109853462 G/A cg19025524 chr12:109796872 NA -0.45 -5.96 -0.31 6.61e-9 Neuroticism; CRC cis rs4727027 0.901 rs1534197 chr7:148771970 T/C cg23583168 chr7:148888333 NA -0.86 -14.54 -0.63 2.36e-37 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC cis rs7249142 0.549 rs1858846 chr19:19281187 T/G cg08207377 chr19:19281140 LOC729991-MEF2B;MEF2B -0.38 -6.13 -0.32 2.52e-9 IgG glycosylation; CRC cis rs992157 0.866 rs2292554 chr2:219146868 T/C cg04731861 chr2:219085781 ARPC2 0.34 6.98 0.36 1.65e-11 Colorectal cancer; CRC cis rs6866614 0.608 rs17132288 chr5:131336105 C/T cg09877947 chr5:131593287 PDLIM4 0.33 5.9 0.31 9.26e-9 Perceived unattractiveness to mosquitoes; CRC trans rs7267979 0.718 rs2983489 chr20:25244120 C/A cg17903999 chr18:56338584 MALT1 -0.41 -6.42 -0.33 4.79e-10 Liver enzyme levels (alkaline phosphatase); CRC cis rs2859741 0.546 rs2102087 chr1:37482849 G/A cg09363841 chr1:37513479 NA -0.45 -7.16 -0.37 5.46e-12 Forced expiratory volume in 1 second (environmental tobacco smoke interaction); CRC cis rs12188164 0.686 rs56279338 chr5:416118 G/A cg17553881 chr5:443987 EXOC3;C5orf55 -0.34 -7.14 -0.37 6.05e-12 Cystic fibrosis severity; CRC cis rs919433 0.589 rs7601800 chr2:198395099 T/C cg10820045 chr2:198174542 NA 0.4 6.88 0.35 3.02e-11 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC cis rs2228479 0.867 rs11642451 chr16:89958127 T/C cg04013166 chr16:89971882 TCF25 0.6 5.76 0.3 1.91e-8 Skin colour saturation; CRC trans rs12432203 1.000 rs12432203 chr14:51710861 A/G cg14592830 chr9:122318704 NA 0.61 6.23 0.32 1.4e-9 Cancer; CRC cis rs7224685 0.501 rs781847 chr17:3958194 G/A cg09695851 chr17:3907499 NA 0.78 14.7 0.63 6.01e-38 Type 2 diabetes; CRC cis rs8070740 0.838 rs8072363 chr17:5335752 C/T cg25236894 chr17:5323110 RPAIN;NUP88 0.43 5.63 0.3 3.79e-8 Menopause (age at onset); CRC cis rs6570726 0.967 rs9403706 chr6:145795187 C/T cg23711669 chr6:146136114 FBXO30 -0.62 -10.48 -0.5 2.38e-22 Lobe attachment (rater-scored or self-reported); CRC cis rs6502050 0.835 rs35131307 chr17:80128439 G/A cg13198984 chr17:80129470 CCDC57 0.46 8.13 0.41 9e-15 Life satisfaction; CRC cis rs787274 0.850 rs10759603 chr9:115639581 C/G cg13803584 chr9:115635662 SNX30 -0.66 -5.97 -0.31 6.04e-9 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs597539 0.652 rs569777 chr11:68706848 G/A cg06028808 chr11:68637592 NA 0.37 5.92 0.31 8.09e-9 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs10193935 0.792 rs10204778 chr2:42498121 G/T cg27598129 chr2:42591480 NA -0.73 -8.22 -0.41 4.9e-15 Colonoscopy-negative controls vs population controls; CRC cis rs2404602 0.692 rs67010831 chr15:76965308 T/G cg22467129 chr15:76604101 ETFA -0.39 -6.54 -0.34 2.38e-10 Blood metabolite levels; CRC cis rs10779751 1.000 rs1010447 chr1:11269796 A/G cg08854313 chr1:11322531 MTOR 0.6 8.56 0.43 4.31e-16 Body mass index; CRC cis rs9914988 0.943 rs9893782 chr17:27108132 C/T cg07195577 chr17:27052828 TLCD1 0.42 6.02 0.32 4.64e-9 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs752010 0.875 rs11210501 chr1:42091634 T/C cg06885757 chr1:42089581 HIVEP3 0.37 6.57 0.34 1.98e-10 Lupus nephritis in systemic lupus erythematosus; CRC cis rs3733585 0.699 rs7686538 chr4:9948077 C/T cg11266682 chr4:10021025 SLC2A9 -0.46 -9.11 -0.45 7.94e-18 Cleft plate (environmental tobacco smoke interaction); CRC cis rs4481887 0.861 rs4486480 chr1:248449714 C/T cg13385794 chr1:248469461 NA 0.37 6.25 0.33 1.26e-9 Common traits (Other); CRC cis rs10504229 0.683 rs55637580 chr8:58135419 C/T cg02725872 chr8:58115012 NA -0.64 -11.55 -0.54 3.85e-26 Developmental language disorder (linguistic errors); CRC cis rs4588572 0.570 rs2115433 chr5:77700363 C/T cg11446398 chr5:77624930 NA 0.43 6.33 0.33 8.01e-10 Triglycerides; CRC cis rs1506636 1.000 rs12333705 chr7:123356062 C/T cg03229431 chr7:123269106 ASB15 -0.74 -11.96 -0.55 1.28e-27 Plateletcrit;Platelet count; CRC cis rs2204008 0.837 rs8189467 chr12:38241956 T/C cg13010199 chr12:38710504 ALG10B 0.45 5.95 0.31 6.72e-9 Bladder cancer; CRC cis rs3617 0.573 rs12492391 chr3:52912296 C/A cg15147215 chr3:52552868 STAB1 -0.42 -6.88 -0.35 3.03e-11 Red blood cell count;Autism spectrum disorder or schizophrenia; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg11353368 chr19:47363757 NA 0.43 6.51 0.34 2.85e-10 Intelligence (multi-trait analysis); CRC cis rs6502050 0.835 rs4789675 chr17:80123144 G/A cg11859384 chr17:80120422 CCDC57 -0.36 -5.75 -0.3 2.06e-8 Life satisfaction; CRC cis rs1163251 0.902 rs839605 chr1:120217524 C/A cg19096424 chr1:120255104 PHGDH 0.46 6.65 0.34 1.2e-10 Blood metabolite levels; CRC cis rs13108904 0.840 rs13106092 chr4:1257290 T/A cg05665937 chr4:1216051 CTBP1 0.41 6.05 0.32 3.93e-9 Obesity-related traits; CRC cis rs1799949 1.000 rs16941 chr17:41244435 T/C cg01879757 chr17:41196368 BRCA1 -0.41 -6.02 -0.32 4.55e-9 Menopause (age at onset); CRC cis rs6121246 0.511 rs879982 chr20:30398510 A/G cg13852791 chr20:30311386 BCL2L1 0.8 15.86 0.66 1.76e-42 Mean corpuscular hemoglobin; CRC cis rs11098499 0.789 rs12498994 chr4:120250818 A/C cg24375607 chr4:120327624 NA 0.47 7.6 0.39 3.06e-13 Corneal astigmatism; CRC cis rs950169 0.614 rs12911536 chr15:84673030 G/T cg11189052 chr15:85197271 WDR73 0.55 7.28 0.37 2.4e-12 Schizophrenia; CRC cis rs10504229 1.000 rs58382845 chr8:58169851 A/C cg24829409 chr8:58192753 C8orf71 -0.67 -11.0 -0.52 3.54e-24 Developmental language disorder (linguistic errors); CRC cis rs10256972 0.568 rs1133043 chr7:1133305 C/G cg07308232 chr7:1071921 C7orf50 -0.44 -5.98 -0.31 5.88e-9 Longevity;Endometriosis; CRC cis rs853679 0.517 rs9393895 chr6:28127621 T/C cg12963246 chr6:28129442 ZNF389 0.49 5.71 0.3 2.53e-8 Depression; CRC cis rs9910055 1.000 rs9895423 chr17:42285740 T/C cg10896456 chr17:42255109 ASB16;C17orf65 0.39 6.24 0.33 1.33e-9 Total body bone mineral density; CRC cis rs367943 0.966 rs348945 chr5:112822889 C/T cg12552261 chr5:112820674 MCC -0.49 -7.52 -0.38 5.23e-13 Type 2 diabetes; CRC cis rs9325144 0.560 rs2387923 chr12:38662677 G/A cg26384229 chr12:38710491 ALG10B -0.49 -7.26 -0.37 2.89e-12 Morning vs. evening chronotype; CRC cis rs832540 0.564 rs33329 chr5:56145068 T/C cg12311346 chr5:56204834 C5orf35 -0.53 -7.85 -0.4 5.77e-14 Coronary artery disease; CRC cis rs995000 0.839 rs12403207 chr1:62993620 T/C cg19896129 chr1:63156450 NA -0.45 -6.94 -0.36 2.07e-11 Triglyceride levels; CRC cis rs9326248 0.520 rs6589602 chr11:117037065 T/C cg26566898 chr11:117069891 TAGLN 0.32 6.7 0.35 9.32e-11 Blood protein levels; CRC cis rs9649213 0.593 rs3801264 chr7:97950620 A/G cg00277769 chr7:97922759 BAIAP2L1 -0.61 -10.7 -0.51 4.06e-23 Prostate cancer (SNP x SNP interaction); CRC cis rs3733585 0.605 rs4697710 chr4:10122649 T/C cg11266682 chr4:10021025 SLC2A9 -0.47 -8.47 -0.42 8.34e-16 Cleft plate (environmental tobacco smoke interaction); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg25307556 chr1:246729459 CNST;TFB2M 0.4 5.96 0.31 6.36e-9 Intelligence (multi-trait analysis); CRC cis rs4285028 0.948 rs71329247 chr3:121681523 C/T cg11130432 chr3:121712080 ILDR1 -0.52 -6.58 -0.34 1.89e-10 Multiple sclerosis; CRC cis rs7412746 0.658 rs4970987 chr1:150949682 T/C cg10589385 chr1:150898437 SETDB1 0.32 6.54 0.34 2.4e-10 Melanoma; CRC cis rs13202913 0.652 rs9383578 chr6:151838192 C/T cg10883421 chr6:151773342 RMND1;C6orf211 0.56 6.4 0.33 5.29e-10 Epstein-Barr virus copy number in lymphoblastoid cell lines; CRC cis rs7264396 0.635 rs6058344 chr20:34475038 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.61 -10.27 -0.49 1.2e-21 Total cholesterol levels; CRC cis rs514406 0.861 rs562182 chr1:53270010 C/T cg24675658 chr1:53192096 ZYG11B -0.55 -7.8 -0.4 8.13e-14 Monocyte count; CRC cis rs2739330 0.796 rs5760106 chr22:24250645 A/C cg18538332 chr22:24372958 LOC391322 0.73 11.42 0.53 1.16e-25 Liver enzyme levels (gamma-glutamyl transferase); CRC trans rs1005277 0.522 rs7090858 chr10:38003670 A/C cg17830980 chr10:43048298 ZNF37B 0.4 6.16 0.32 2.12e-9 Extrinsic epigenetic age acceleration; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg22466830 chr18:9475498 RALBP1 0.43 5.96 0.31 6.34e-9 Anxiety disorder; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg07437056 chr6:2765594 WRNIP1 0.46 6.36 0.33 6.66e-10 Anxiety disorder; CRC cis rs9611565 0.512 rs132767 chr22:42009520 C/T cg06634786 chr22:41940651 POLR3H -0.58 -6.23 -0.32 1.4e-9 Vitiligo; CRC cis rs46522 0.585 rs79049364 chr17:47014991 T/A cg00947319 chr17:47005597 UBE2Z -0.35 -5.88 -0.31 9.86e-9 Coronary heart disease; CRC cis rs5753618 0.561 rs737887 chr22:31696615 A/G cg07713946 chr22:31675144 LIMK2 -0.39 -5.67 -0.3 3.09e-8 Colorectal cancer; CRC cis rs7916697 0.626 rs3858144 chr10:70011354 A/G cg06988349 chr10:69991859 ATOH7 0.37 7.02 0.36 1.27e-11 Optic disc area; CRC cis rs10971721 0.822 rs10971774 chr9:33900109 C/T cg13495928 chr9:33750294 PRSS3 0.56 5.97 0.31 6.15e-9 Body mass index; CRC cis rs8038465 0.638 rs12591473 chr15:73967485 A/T cg15420318 chr15:73925796 NPTN 0.4 6.12 0.32 2.72e-9 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs875971 0.964 rs6978721 chr7:65883204 A/G cg18912574 chr7:65842487 NCRNA00174 0.36 6.18 0.32 1.88e-9 Aortic root size; CRC cis rs6502050 0.835 rs56095560 chr17:80151304 C/T cg09264619 chr17:80180166 NA -0.37 -6.17 -0.32 2.04e-9 Life satisfaction; CRC cis rs10256972 0.706 rs4285396 chr7:1123738 A/G cg03923535 chr7:1197113 ZFAND2A 0.63 8.9 0.44 3.96e-17 Longevity;Endometriosis; CRC cis rs9463078 0.774 rs9369558 chr6:45274021 A/C cg25276700 chr6:44698697 NA -0.29 -6.94 -0.36 2.09e-11 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; CRC cis rs12410462 0.591 rs11802190 chr1:227635162 A/C cg04117972 chr1:227635322 NA 0.45 5.95 0.31 6.98e-9 Major depressive disorder; CRC cis rs801193 1.000 rs2420824 chr7:66131116 G/A cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.4 -5.92 -0.31 8.25e-9 Aortic root size; CRC cis rs7258465 1.000 rs10405636 chr19:18538742 A/C cg06953865 chr19:18549723 ISYNA1 -0.39 -5.77 -0.3 1.81e-8 Breast cancer; CRC cis rs1050631 0.657 rs1789551 chr18:33716092 G/A cg25426722 chr18:33708991 SLC39A6;ELP2 0.37 5.73 0.3 2.27e-8 Esophageal squamous cell cancer (length of survival); CRC cis rs1577917 0.959 rs34258068 chr6:86679449 C/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.52 -6.78 -0.35 5.74e-11 Response to antipsychotic treatment; CRC cis rs1707322 0.964 rs12067716 chr1:46434428 T/A cg03146154 chr1:46216737 IPP 0.57 7.98 0.4 2.4e-14 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs5750830 0.649 rs5750811 chr22:39793066 G/T cg11247378 chr22:39784982 NA 0.45 8.06 0.41 1.41e-14 Intelligence (multi-trait analysis); CRC cis rs780096 0.506 rs1728922 chr2:27644464 A/C cg22903471 chr2:27725779 GCKR -0.37 -6.07 -0.32 3.43e-9 Total body bone mineral density; CRC cis rs208515 0.556 rs12214562 chr6:66681011 T/A cg07460842 chr6:66804631 NA 0.95 12.02 0.55 7.47e-28 Exhaled nitric oxide levels; CRC cis rs62064224 0.553 rs9896320 chr17:30689814 G/A cg12855166 chr17:30846586 MYO1D -0.37 -6.04 -0.32 4.26e-9 Schizophrenia; CRC trans rs60843830 0.928 rs2306060 chr2:230912 A/C cg11347411 chr7:150020925 ACTR3C;LRRC61 0.6 9.4 0.46 9.88e-19 Spherical equivalent (joint analysis main effects and education interaction); CRC cis rs6951245 0.786 rs77943789 chr7:1140158 C/T cg04025307 chr7:1156635 C7orf50 0.67 7.66 0.39 2.13e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs6951245 0.638 rs74976697 chr7:1160505 C/T cg21664854 chr7:1097933 C7orf50;GPR146 0.69 8.26 0.41 3.57e-15 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs875971 0.928 rs2036263 chr7:65800197 C/T cg11764359 chr7:65958608 NA -0.61 -9.44 -0.46 6.9e-19 Aortic root size; CRC cis rs6960043 0.818 rs2215383 chr7:15062983 T/C cg19272540 chr7:15055459 NA -0.22 -5.91 -0.31 8.61e-9 Type 2 diabetes; CRC cis rs10504229 0.683 rs61241336 chr8:58106585 A/G cg24829409 chr8:58192753 C8orf71 -0.56 -8.01 -0.4 2.05e-14 Developmental language disorder (linguistic errors); CRC cis rs2976388 0.609 rs2164308 chr8:143785659 A/G cg22687807 chr8:143858763 LYNX1 -0.5 -8.92 -0.44 3.42e-17 Urinary tract infection frequency; CRC trans rs61101201 1.000 rs1223079 chr11:31456846 T/A cg11934170 chr4:155254326 DCHS2 -0.41 -5.96 -0.31 6.41e-9 Optic disc area; CRC cis rs7493 0.755 rs17166861 chr7:95020602 G/C cg19678392 chr7:94953810 PON1 -0.55 -6.72 -0.35 8.11e-11 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs9894429 0.646 rs9902264 chr17:79613828 G/A cg21028142 chr17:79581711 NPLOC4 0.34 7.16 0.37 5.16e-12 Eye color traits; CRC cis rs3790844 0.501 rs12035139 chr1:199951850 G/A cg13229857 chr1:200006247 NR5A2 0.51 7.62 0.39 2.68e-13 Pancreatic cancer; CRC cis rs8013055 0.846 rs10147392 chr14:105978537 T/G cg25008857 chr14:105974488 NA 0.43 6.13 0.32 2.54e-9 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis); CRC cis rs7945718 0.839 rs763373 chr11:12840342 C/G cg25843174 chr11:12811716 TEAD1 -0.51 -9.55 -0.47 3.06e-19 Educational attainment (years of education); CRC cis rs9467773 0.873 rs9295698 chr6:26566099 T/A cg09904177 chr6:26538194 HMGN4 0.85 14.77 0.63 3.2e-38 Intelligence (multi-trait analysis); CRC cis rs9926296 0.568 rs7203907 chr16:89833774 C/G cg21285383 chr16:89894308 SPIRE2 0.34 5.78 0.3 1.75e-8 Vitiligo; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg07936541 chr2:98206095 ANKRD36B 0.49 6.58 0.34 1.89e-10 Thyroid stimulating hormone; CRC cis rs7107770 0.629 rs7104313 chr11:125070197 A/C cg27629782 chr11:125073726 PKNOX2 -0.47 -6.66 -0.34 1.15e-10 Photic sneeze reflex; CRC cis rs10540 0.558 rs12806062 chr11:501429 G/A cg03352830 chr11:487213 PTDSS2 0.68 7.47 0.38 7.24e-13 Body mass index; CRC cis rs1348850 0.632 rs11678875 chr2:178509068 A/G cg02961200 chr2:178257176 LOC100130691;AGPS 0.64 8.97 0.44 2.23e-17 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs6860806 0.507 rs2631364 chr5:131706914 C/G cg12564285 chr5:131593104 PDLIM4 -0.46 -7.69 -0.39 1.76e-13 Breast cancer; CRC cis rs1862618 0.853 rs832553 chr5:56114786 A/G cg12311346 chr5:56204834 C5orf35 -0.77 -10.29 -0.49 1.04e-21 Initial pursuit acceleration; CRC cis rs919433 0.963 rs4850430 chr2:198182796 A/T cg03934865 chr2:198174659 NA -0.43 -6.81 -0.35 4.66e-11 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC cis rs1552244 0.882 rs34706481 chr3:10004123 G/A cg18598329 chr3:10140678 FANCD2;C3orf24 -0.73 -8.76 -0.44 1.02e-16 Alzheimer's disease; CRC cis rs67478160 0.643 rs34813623 chr14:104263294 A/G cg01849466 chr14:104193079 ZFYVE21 -0.47 -8.38 -0.42 1.52e-15 Schizophrenia; CRC cis rs9467603 0.925 rs3949215 chr6:25777497 A/T cg16898833 chr6:26189333 HIST1H4D -0.7 -5.97 -0.31 6.28e-9 Intelligence (multi-trait analysis); CRC cis rs736408 0.505 rs2083180 chr3:52668119 G/T cg08222913 chr3:52553049 STAB1 -0.33 -6.24 -0.33 1.33e-9 Bipolar disorder; CRC cis rs514406 0.661 rs562641 chr1:53374666 C/T cg08859206 chr1:53392774 SCP2 -0.6 -9.27 -0.46 2.46e-18 Monocyte count; CRC cis rs2153535 0.546 rs1335640 chr6:8485325 A/C cg07606381 chr6:8435919 SLC35B3 0.68 10.89 0.51 8.84e-24 Motion sickness; CRC cis rs798554 0.797 rs35957220 chr7:2812632 C/G cg19717773 chr7:2847554 GNA12 -0.47 -6.57 -0.34 1.97e-10 Height; CRC cis rs4363385 0.818 rs2339492 chr1:152985552 G/C cg25856811 chr1:152973957 SPRR3 -0.24 -6.72 -0.35 8.13e-11 Inflammatory skin disease; CRC cis rs68170813 0.559 rs76208112 chr7:106964222 C/T cg02696742 chr7:106810147 HBP1 -0.56 -6.07 -0.32 3.45e-9 Coronary artery disease; CRC cis rs853679 0.546 rs200950 chr6:27835772 A/G cg23259851 chr6:27775964 HIST1H2AI;HIST1H2BL 0.71 5.93 0.31 7.83e-9 Depression; CRC cis rs8067545 0.750 rs7223305 chr17:19990986 A/G cg13482628 chr17:19912719 NA 0.5 7.85 0.4 5.97e-14 Schizophrenia; CRC cis rs9733 0.544 rs72700902 chr1:150633347 C/T cg15448220 chr1:150897856 SETDB1 0.47 6.77 0.35 6.05e-11 Tonsillectomy; CRC cis rs12477438 0.501 rs6751927 chr2:99740175 T/C cg26064155 chr2:99771622 LIPT1;TSGA10 0.91 16.79 0.68 3.83e-46 Chronic sinus infection; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg22476897 chr7:30518609 NOD1 0.43 6.12 0.32 2.66e-9 Response to antipsychotic treatment; CRC cis rs1862618 0.802 rs2591949 chr5:56132627 T/C cg20203395 chr5:56204925 C5orf35 -0.71 -8.56 -0.43 4.27e-16 Initial pursuit acceleration; CRC cis rs4589502 0.800 rs1498499 chr15:67202620 C/T cg09911534 chr15:67153556 NA 0.45 6.07 0.32 3.43e-9 Lung cancer (smoking interaction); CRC cis rs9435341 0.965 rs1730864 chr1:107607810 C/T cg11070056 chr1:107600091 PRMT6 -0.42 -6.01 -0.31 4.88e-9 Facial morphology (factor 21, depth of nasal alae); CRC cis rs1577917 0.959 rs2816822 chr6:86658292 A/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.45 -5.86 -0.31 1.1e-8 Response to antipsychotic treatment; CRC cis rs950169 0.579 rs881983 chr15:84647308 C/T cg11189052 chr15:85197271 WDR73 0.55 7.4 0.38 1.14e-12 Schizophrenia; CRC cis rs1799949 0.930 rs4584865 chr17:41424919 C/G cg01879757 chr17:41196368 BRCA1 -0.43 -6.63 -0.34 1.4e-10 Menopause (age at onset); CRC trans rs7618501 1.000 rs2271961 chr3:49878113 C/T cg21659725 chr3:3221576 CRBN -0.91 -18.18 -0.71 1.23e-51 Intelligence (multi-trait analysis); CRC cis rs4862750 0.872 rs56389997 chr4:187894796 A/C cg27532560 chr4:187881888 NA -0.56 -10.25 -0.49 1.42e-21 Lobe attachment (rater-scored or self-reported); CRC cis rs2204008 0.652 rs11520002 chr12:38022179 G/T cg26384229 chr12:38710491 ALG10B 0.68 9.03 0.45 1.48e-17 Bladder cancer; CRC cis rs2463822 0.583 rs72919472 chr11:62040655 C/T cg06239285 chr11:62104954 ASRGL1 -0.77 -7.84 -0.4 6.49e-14 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs2153535 0.580 rs6421949 chr6:8531769 G/A cg21535247 chr6:8435926 SLC35B3 0.48 7.39 0.38 1.26e-12 Motion sickness; CRC cis rs9768139 0.634 rs56389048 chr7:158121368 T/A cg23298862 chr7:158159286 PTPRN2 0.4 6.23 0.33 1.39e-9 Calcium levels; CRC cis rs4665809 0.590 rs4665840 chr2:26444962 C/T cg04944784 chr2:26401820 FAM59B -0.83 -10.74 -0.51 2.96e-23 Gut microbiome composition (summer); CRC cis rs2730260 0.537 rs3793224 chr7:158876573 G/A cg02254261 chr7:158964346 NA -0.53 -6.07 -0.32 3.6e-9 Myopia (pathological); CRC cis rs4481887 0.708 rs6587463 chr1:248544452 G/C cg26353448 chr1:248524236 OR2T4 -0.32 -6.17 -0.32 2.02e-9 Common traits (Other); CRC cis rs2242663 0.798 rs1945302 chr11:66337498 C/T cg24851651 chr11:66362959 CCS 0.44 7.22 0.37 3.67e-12 Bipolar disorder; CRC cis rs7258465 0.931 rs1560119 chr19:18573675 A/G cg10790698 chr19:18539756 SSBP4 -0.45 -8.69 -0.43 1.69e-16 Breast cancer; CRC trans rs7395662 0.929 rs10838959 chr11:48584732 T/A cg21153622 chr11:89784906 NA -0.46 -7.35 -0.38 1.54e-12 HDL cholesterol; CRC cis rs736408 0.562 rs2072390 chr3:52780509 A/T cg15147215 chr3:52552868 STAB1 -0.64 -10.83 -0.51 1.4e-23 Bipolar disorder; CRC cis rs1784581 0.588 rs7451121 chr6:162412344 A/G cg17173639 chr6:162384350 PARK2 0.6 9.65 0.47 1.47e-19 Itch intensity from mosquito bite; CRC cis rs4589502 0.925 rs4259997 chr15:67153310 A/G cg12317470 chr15:67143691 NA -0.68 -7.63 -0.39 2.59e-13 Lung cancer (smoking interaction); CRC cis rs9326248 0.520 rs6589602 chr11:117037065 T/C cg01368799 chr11:117014884 PAFAH1B2 0.57 9.35 0.46 1.35e-18 Blood protein levels; CRC trans rs3733585 0.805 rs882222 chr4:9981294 G/A cg26043149 chr18:55253948 FECH 0.54 8.27 0.41 3.27e-15 Cleft plate (environmental tobacco smoke interaction); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg21939482 chr7:6388130 C7orf70 0.44 6.21 0.32 1.57e-9 Response to antipsychotic treatment; CRC cis rs4713118 0.616 rs9348789 chr6:28025486 C/T cg15845792 chr6:28175446 NA 0.96 13.94 0.61 5.17e-35 Parkinson's disease; CRC cis rs6723226 0.803 rs176415 chr2:32649778 G/A cg02381751 chr2:32503542 YIPF4 -0.63 -9.16 -0.45 5.53e-18 Intelligence (multi-trait analysis); CRC cis rs427941 0.632 rs201492 chr7:101754138 C/T cg06246474 chr7:101738831 CUX1 0.44 6.73 0.35 7.61e-11 Plasma omega-3 polyunsaturated fatty acid level (eicosapentaenoic acid); CRC cis rs3796619 1.000 rs55741287 chr4:1094670 T/C cg27284194 chr4:1044797 NA 0.38 5.95 0.31 6.69e-9 Recombination rate (males); CRC cis rs3018066 0.748 rs28391259 chr4:107014012 C/A cg01869342 chr4:106983673 TBCK 0.44 6.4 0.33 5.49e-10 Cancer; CRC cis rs4285028 0.948 rs2091664 chr3:121684749 T/A cg11130432 chr3:121712080 ILDR1 -0.52 -6.75 -0.35 6.81e-11 Multiple sclerosis; CRC cis rs875971 0.545 rs4718335 chr7:65804606 C/T cg18876405 chr7:65276391 NA 0.46 6.44 0.33 4.29e-10 Aortic root size; CRC cis rs9527 0.615 rs7899622 chr10:104727333 C/T cg04362960 chr10:104952993 NT5C2 0.61 8.52 0.43 5.91e-16 Arsenic metabolism; CRC cis rs9814567 1.000 rs9871305 chr3:134213538 C/T cg06109529 chr3:134205091 CEP63;ANAPC13 -0.82 -12.23 -0.56 1.32e-28 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs2204008 0.837 rs11612125 chr12:38213212 C/T cg26384229 chr12:38710491 ALG10B 0.69 9.26 0.45 2.81e-18 Bladder cancer; CRC cis rs9910055 0.821 rs4473241 chr17:42281282 G/T cg19774624 chr17:42201019 HDAC5 -0.65 -10.24 -0.49 1.48e-21 Total body bone mineral density; CRC cis rs2276314 0.512 rs1789506 chr18:33625370 G/A cg19628046 chr18:33552617 C18orf21 -0.4 -6.16 -0.32 2.13e-9 Endometriosis;Drug-induced torsades de pointes; CRC cis rs9649213 0.593 rs2158553 chr7:97951131 G/A cg24562669 chr7:97807699 LMTK2 0.42 7.04 0.36 1.1e-11 Prostate cancer (SNP x SNP interaction); CRC cis rs35955747 0.778 rs9609263 chr22:31745274 G/T cg02404636 chr22:31891804 SFI1 -0.38 -5.82 -0.31 1.39e-8 Neutrophil count;Sum basophil neutrophil counts; CRC cis rs28386778 0.897 rs4968597 chr17:61805747 G/A cg06601766 chr17:61851465 DDX42;CCDC47 0.43 5.92 0.31 8.09e-9 Prudent dietary pattern; CRC cis rs2952156 0.883 rs1495100 chr17:37832279 C/T cg00129232 chr17:37814104 STARD3 -0.69 -12.24 -0.56 1.17e-28 Asthma; CRC cis rs853679 0.517 rs1947862 chr6:28105196 C/T cg15845792 chr6:28175446 NA 1.01 13.47 0.6 3.16e-33 Depression; CRC cis rs2688608 0.560 rs10128354 chr10:75470045 T/C cg16540259 chr10:75572220 NDST2 0.38 5.8 0.3 1.59e-8 Inflammatory bowel disease; CRC cis rs7666738 0.512 rs1648536 chr4:99019881 G/T cg05340658 chr4:99064831 C4orf37 -0.48 -7.29 -0.37 2.38e-12 Colonoscopy-negative controls vs population controls; CRC cis rs7208859 0.573 rs8078182 chr17:29149664 C/T cg01831904 chr17:28903510 LRRC37B2 -0.55 -6.38 -0.33 5.94e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs1109861 0.783 rs625315 chr10:11225337 G/T cg24910943 chr10:11206320 CUGBP2 0.33 9.01 0.44 1.68e-17 Urinary albumin-to-creatinine ratio; CRC cis rs9549367 0.789 rs9549699 chr13:113878263 T/A cg18105134 chr13:113819100 PROZ -0.72 -10.86 -0.51 1.06e-23 Platelet distribution width; CRC cis rs9926296 0.527 rs1800335 chr16:89846195 A/G cg27121462 chr16:89883253 FANCA 0.59 9.45 0.46 6.48e-19 Vitiligo; CRC cis rs4665809 1.000 rs2289022 chr2:26350136 G/T cg26119090 chr2:26468346 HADHA;HADHB -0.61 -7.88 -0.4 4.97e-14 Gut microbiome composition (summer); CRC cis rs13108904 0.870 rs11721789 chr4:1254414 C/A cg16405210 chr4:1374714 KIAA1530 -0.43 -6.1 -0.32 2.91e-9 Obesity-related traits; CRC cis rs6831352 0.879 rs56295995 chr4:100060899 C/T cg13256891 chr4:100009986 ADH5 -0.65 -8.82 -0.44 6.89e-17 Alcohol dependence; CRC cis rs853679 0.517 rs9393890 chr6:28063855 C/T cg02683197 chr6:28174875 NA 0.82 10.05 0.48 6.9e-21 Depression; CRC cis rs4302906 0.964 rs10121856 chr9:95736264 A/G cg14631576 chr9:95140430 CENPP -0.32 -5.74 -0.3 2.12e-8 Lobe attachment (rater-scored or self-reported); CRC cis rs951366 0.764 rs823143 chr1:205743425 A/C cg23034840 chr1:205782522 SLC41A1 0.48 6.7 0.35 9.11e-11 Menarche (age at onset); CRC cis rs713587 0.525 rs1541984 chr2:25082414 G/A cg22495460 chr2:25135724 ADCY3 -0.84 -16.24 -0.67 5.86e-44 Body mass index in non-asthmatics; CRC cis rs11958404 0.932 rs72816600 chr5:157436349 T/C cg05962755 chr5:157440814 NA 1.01 12.88 0.58 5.12e-31 IgG glycosylation; CRC cis rs9467773 0.583 rs1021373 chr6:26632457 G/A cg09904177 chr6:26538194 HMGN4 0.72 11.39 0.53 1.42e-25 Intelligence (multi-trait analysis); CRC cis rs5758343 1 rs5758343 chr22:41816652 A/T cg03806693 chr22:41940476 POLR3H 1.1 13.39 0.59 6.08e-33 Allergic disease (asthma, hay fever or eczema); CRC trans rs7618501 1.000 rs3749241 chr3:49744392 A/G cg21582582 chr3:182698605 DCUN1D1 -0.56 -8.23 -0.41 4.33e-15 Intelligence (multi-trait analysis); CRC trans rs6703335 0.870 rs10803142 chr1:243598234 A/G cg02567788 chr10:71992279 PPA1 0.44 6.15 0.32 2.28e-9 Schizophrenia;Schizophrenia, schizoaffective disorder or bipolar disorder; CRC cis rs2976388 0.590 rs3736011 chr8:143817789 G/A cg04969067 chr8:143858791 LYNX1 -0.42 -6.76 -0.35 6.24e-11 Urinary tract infection frequency; CRC cis rs4594175 0.926 rs4243570 chr14:51624243 C/T cg23942311 chr14:51606299 NA 0.64 10.73 0.51 3.05e-23 Cancer; CRC cis rs9467711 0.606 rs66823108 chr6:26377939 G/A cg14345882 chr6:26364793 BTN3A2 0.7 6.08 0.32 3.33e-9 Autism spectrum disorder or schizophrenia; CRC cis rs4713118 0.662 rs9468278 chr6:28028482 C/T cg18032046 chr6:28092343 ZSCAN16 -0.5 -6.33 -0.33 7.89e-10 Parkinson's disease; CRC cis rs9534288 0.797 rs7328081 chr13:46611695 T/C cg15192986 chr13:46630673 CPB2 -0.68 -9.89 -0.48 2.31e-20 Blood protein levels; CRC cis rs860295 0.702 rs11264397 chr1:155611485 G/C cg02153340 chr1:155202674 NA -0.55 -6.74 -0.35 7.03e-11 Body mass index; CRC cis rs2933343 0.953 rs2933344 chr3:128658715 A/G cg11901034 chr3:128598214 ACAD9 -0.51 -6.59 -0.34 1.8e-10 IgG glycosylation; CRC cis rs875971 0.862 rs10276077 chr7:65728411 A/G cg18876405 chr7:65276391 NA -0.5 -8.17 -0.41 6.71e-15 Aortic root size; CRC cis rs6942756 0.876 rs1559486 chr7:129015894 C/T cg02491457 chr7:128862824 NA -0.61 -8.51 -0.42 6.34e-16 White matter hyperintensity burden; CRC cis rs4722166 0.630 rs10950916 chr7:22799667 C/T cg05472934 chr7:22766657 IL6 0.8 13.26 0.59 1.88e-32 Lung cancer; CRC cis rs9649213 0.593 rs6465664 chr7:97921834 A/G cg21770322 chr7:97807741 LMTK2 0.54 9.03 0.45 1.52e-17 Prostate cancer (SNP x SNP interaction); CRC cis rs763121 0.889 rs6001209 chr22:39121252 C/T cg06022373 chr22:39101656 GTPBP1 -0.73 -11.25 -0.53 4.44e-25 Menopause (age at onset); CRC cis rs1448094 0.512 rs12314274 chr12:86249196 A/G cg25456477 chr12:86230367 RASSF9 0.34 5.92 0.31 8.19e-9 Major depressive disorder; CRC cis rs13631 0.965 rs7853589 chr9:140003844 A/G cg15396367 chr9:139972779 UAP1L1 -0.49 -7.57 -0.39 3.86e-13 Cerebrospinal fluid biomarker levels; CRC trans rs7395662 0.853 rs4882054 chr11:48399899 A/G cg21153622 chr11:89784906 NA -0.47 -7.31 -0.37 2.02e-12 HDL cholesterol; CRC cis rs9872999 1 rs9872999 chr3:133457514 C/T cg16262614 chr3:133464971 TF 0.5 9.59 0.47 2.32e-19 Iron status biomarkers; CRC cis rs4665809 1.000 rs4665299 chr2:26256840 A/C cg22920501 chr2:26401640 FAM59B -0.55 -7.2 -0.37 4.07e-12 Gut microbiome composition (summer); CRC cis rs710865 0.627 rs10799710 chr1:19483209 A/G cg13387374 chr1:19411106 UBR4 0.47 7.46 0.38 7.64e-13 Brain structure; CRC cis rs9311474 0.508 rs4687629 chr3:52615227 G/C cg08222913 chr3:52553049 STAB1 -0.34 -6.39 -0.33 5.78e-10 Electroencephalogram traits; CRC cis rs1799949 0.859 rs11657004 chr17:41442751 A/G cg23758822 chr17:41437982 NA 0.85 15.96 0.66 7.02e-43 Menopause (age at onset); CRC cis rs1218582 0.772 rs4845688 chr1:154884142 T/C cg03351412 chr1:154909251 PMVK 0.54 8.66 0.43 2.13e-16 Prostate cancer; CRC cis rs10504229 0.954 rs903717 chr8:58167856 A/G cg22535103 chr8:58192502 C8orf71 -0.61 -10.08 -0.49 5.23e-21 Developmental language disorder (linguistic errors); CRC cis rs9916302 0.706 rs4488484 chr17:37717377 A/T cg07936489 chr17:37558343 FBXL20 0.91 12.11 0.56 3.72e-28 Glomerular filtration rate (creatinine); CRC cis rs17401966 0.800 rs12725210 chr1:10416993 G/A cg19773385 chr1:10388646 KIF1B -0.66 -10.72 -0.51 3.52e-23 Hepatocellular carcinoma; CRC cis rs853679 0.517 rs9393891 chr6:28079160 C/T cg15845792 chr6:28175446 NA 1.0 13.1 0.59 7.81e-32 Depression; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg03432716 chr1:6550858 PLEKHG5 0.48 6.64 0.34 1.3100000000000001e-10 Response to antipsychotic treatment; CRC cis rs4253772 0.637 rs8135997 chr22:46651366 G/A cg09491104 chr22:46646882 C22orf40 -0.47 -7.29 -0.37 2.36e-12 LDL cholesterol;Cholesterol, total; CRC cis rs4888262 0.507 rs9888976 chr16:74580924 C/T cg01733217 chr16:74700730 RFWD3 0.73 11.01 0.52 3.2e-24 Testicular germ cell tumor; CRC cis rs3008870 1.000 rs3008888 chr1:67368965 C/T cg08660285 chr1:67390436 MIER1;WDR78 1.05 16.1 0.66 1.98e-43 Lymphocyte percentage of white cells; CRC cis rs2346177 0.781 rs1447563 chr2:46637364 A/C cg26688816 chr2:46740690 ATP6V1E2 -0.5 -7.46 -0.38 7.94e-13 HDL cholesterol; CRC cis rs10992471 0.603 rs11794346 chr9:95247288 C/T cg14631576 chr9:95140430 CENPP -0.38 -6.59 -0.34 1.73e-10 Visceral adipose tissue/subcutaneous adipose tissue ratio; CRC cis rs9322193 0.962 rs9322218 chr6:150103319 A/G cg05861140 chr6:150128134 PCMT1 -0.4 -6.58 -0.34 1.82e-10 Lung cancer; CRC cis rs60843830 1.000 rs7566279 chr2:281178 C/G cg00108164 chr2:264199 ACP1;SH3YL1 0.61 9.62 0.47 1.84e-19 Spherical equivalent (joint analysis main effects and education interaction); CRC cis rs9549367 0.713 rs3024744 chr13:113821477 A/C cg18105134 chr13:113819100 PROZ -0.87 -13.4 -0.59 5.85e-33 Platelet distribution width; CRC cis rs9399135 0.967 rs17638970 chr6:135320063 A/G cg24558204 chr6:135376177 HBS1L 0.51 8.13 0.41 9e-15 Red blood cell count; CRC trans rs951252 0.504 rs11734405 chr4:146081096 C/T cg25220428 chr6:19144084 NA -0.48 -6.4 -0.33 5.22e-10 Hip circumference; CRC cis rs1552244 0.935 rs28815328 chr3:10062227 G/A cg16606324 chr3:10149918 C3orf24 0.68 9.18 0.45 5.04e-18 Alzheimer's disease; CRC cis rs7618915 0.501 rs6804145 chr3:52694198 C/T cg18099408 chr3:52552593 STAB1 -0.47 -8.01 -0.4 2.01e-14 Bipolar disorder; CRC cis rs11098699 0.821 rs6830451 chr4:124230386 G/A cg09941581 chr4:124220074 SPATA5 0.39 5.81 0.3 1.49e-8 Mosquito bite size; CRC cis rs10946940 0.965 rs6915266 chr6:27528643 G/A cg20933634 chr6:27740509 NA -0.39 -5.67 -0.3 3.21e-8 Systemic lupus erythematosus; CRC cis rs12586317 0.545 rs58342373 chr14:35395269 T/C cg05294307 chr14:35346193 BAZ1A -0.55 -6.72 -0.35 7.92e-11 Psoriasis; CRC cis rs6714710 0.580 rs11680018 chr2:98479581 C/A cg26665480 chr2:98280029 ACTR1B 0.54 7.31 0.37 2.07e-12 Posterior cortical atrophy and Alzheimer's disease; CRC cis rs67311347 1.000 rs56303661 chr3:40520778 C/G cg24209194 chr3:40518798 ZNF619 0.41 5.75 0.3 2.04e-8 Renal cell carcinoma; CRC cis rs10256972 0.685 rs10263665 chr7:1110628 A/G cg04025307 chr7:1156635 C7orf50 0.49 7.45 0.38 8.29e-13 Longevity;Endometriosis; CRC cis rs11229555 0.645 rs12273638 chr11:58186335 T/C cg15696309 chr11:58395628 NA -0.81 -10.33 -0.49 7.4e-22 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; CRC cis rs12900413 0.603 rs4448912 chr15:90299690 G/A cg24249390 chr15:90295951 MESP1 -0.58 -8.85 -0.44 5.57e-17 Coronary artery aneurysm in Kawasaki disease; CRC cis rs12497850 0.764 rs6784111 chr3:49178846 T/C cg07636037 chr3:49044803 WDR6 0.94 14.88 0.63 1.17e-38 Parkinson's disease; CRC cis rs3823572 0.548 rs2971981 chr7:133651555 T/C cg03336402 chr7:133662267 EXOC4 -0.69 -10.78 -0.51 2.15e-23 Intelligence (multi-trait analysis); CRC cis rs7769051 0.808 rs1467403 chr6:133089952 T/A cg22852734 chr6:133119734 C6orf192 0.91 10.8 0.51 1.77e-23 Type 2 diabetes nephropathy; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg06843030 chr22:41697630 ZC3H7B 0.38 6.12 0.32 2.6e-9 Liver disease severity in Alagille syndrome; CRC cis rs6504622 0.577 rs35707546 chr17:45001541 G/A cg16759221 chr17:45003025 GOSR2 0.64 10.35 0.5 6.31e-22 Orofacial clefts; CRC cis rs4713118 0.955 rs9368528 chr6:27683798 G/A cg06470822 chr6:28175283 NA 0.67 9.07 0.45 1.1e-17 Parkinson's disease; CRC cis rs7932354 0.528 rs7479189 chr11:47057009 T/A cg03339077 chr11:47165057 C11orf49 0.44 6.24 0.33 1.35e-9 Bone mineral density (hip);Bone mineral density; CRC cis rs644799 0.710 rs10831427 chr11:95508383 G/T cg25622487 chr11:95524042 FAM76B;CEP57 0.8 13.17 0.59 4.16e-32 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC trans rs11098499 0.954 rs34858317 chr4:120387110 A/C cg25214090 chr10:38739885 LOC399744 0.66 10.55 0.5 1.36e-22 Corneal astigmatism; CRC cis rs12618769 0.597 rs17505326 chr2:99156807 T/A cg18455616 chr2:99124870 INPP4A 0.36 5.9 0.31 8.84e-9 Bipolar disorder; CRC cis rs728616 0.867 rs56235549 chr10:81834948 G/A cg11900509 chr10:81946545 ANXA11 -0.55 -5.93 -0.31 7.73e-9 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs11997175 0.524 rs10954932 chr8:33650176 A/C ch.8.33884649F chr8:33765107 NA 0.47 7.45 0.38 8.11e-13 Body mass index; CRC cis rs651907 0.557 rs11712748 chr3:101383562 G/A cg11279151 chr3:101281821 RG9MTD1 -0.5 -6.77 -0.35 6.03e-11 Colorectal cancer; CRC cis rs2795502 1.000 rs2795503 chr10:43347224 T/A cg20628663 chr10:43360327 NA -0.69 -10.8 -0.51 1.84e-23 Blood protein levels; CRC cis rs9322193 0.962 rs7740784 chr6:150154500 C/T cg00933542 chr6:150070202 PCMT1 0.31 5.89 0.31 9.61e-9 Lung cancer; CRC cis rs9443189 0.530 rs614065 chr6:76315633 G/A cg01950844 chr6:76311363 SENP6 0.74 9.53 0.47 3.56e-19 Prostate cancer; CRC cis rs2573652 1.000 rs2727198 chr15:100513722 T/C cg00587665 chr15:100533223 ADAMTS17 -0.36 -6.11 -0.32 2.84e-9 Height; CRC cis rs6545883 0.859 rs2600661 chr2:61543081 T/C cg15711740 chr2:61764176 XPO1 0.45 6.19 0.32 1.81e-9 Tuberculosis; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg24361086 chr7:123388661 WASL 0.54 7.71 0.39 1.51e-13 Response to antipsychotic treatment; CRC cis rs10540 1.000 rs35996687 chr11:458595 G/A cg19913688 chr11:428466 ANO9 -0.72 -6.9 -0.36 2.72e-11 Body mass index; CRC cis rs9916302 0.706 rs9890198 chr17:37457480 A/C cg07936489 chr17:37558343 FBXL20 0.86 10.44 0.5 3.27e-22 Glomerular filtration rate (creatinine); CRC cis rs7927771 0.832 rs935914 chr11:47387599 C/T cg05585544 chr11:47624801 NA 0.46 8.16 0.41 7.15e-15 Subjective well-being; CRC cis rs977987 0.806 rs2865531 chr16:75390316 T/A cg03315344 chr16:75512273 CHST6 0.52 8.73 0.43 1.35e-16 Dupuytren's disease; CRC cis rs6921919 0.525 rs1361386 chr6:28305604 G/A cg06470822 chr6:28175283 NA 0.48 6.43 0.33 4.59e-10 Autism spectrum disorder or schizophrenia; CRC cis rs1023500 0.596 rs133369 chr22:42463814 C/T cg15557168 chr22:42548783 NA -0.37 -6.32 -0.33 8.49e-10 Schizophrenia; CRC cis rs1712517 0.873 rs7894240 chr10:105000369 T/C cg05636881 chr10:105038444 INA -0.46 -8.11 -0.41 1.02e-14 Migraine; CRC cis rs3733585 0.624 rs7376154 chr4:9952587 C/A cg00071950 chr4:10020882 SLC2A9 -0.55 -9.74 -0.47 7.09e-20 Cleft plate (environmental tobacco smoke interaction); CRC cis rs7843479 0.965 rs2291317 chr8:21827162 C/T cg17168535 chr8:21777572 XPO7 0.62 10.58 0.5 1.01e-22 Mean corpuscular volume; CRC cis rs7215564 0.818 rs4889881 chr17:78664157 T/C cg09596252 chr17:78655493 RPTOR 0.55 6.08 0.32 3.29e-9 Myopia (pathological); CRC cis rs172166 0.611 rs203882 chr6:28078502 G/A cg02683197 chr6:28174875 NA 0.68 9.38 0.46 1.09e-18 Cardiac Troponin-T levels; CRC cis rs9322193 0.962 rs35443312 chr6:149991761 T/C cg13206674 chr6:150067644 NUP43 0.58 8.29 0.42 2.94e-15 Lung cancer; CRC cis rs787274 1.000 rs787271 chr9:115549463 C/T cg13803584 chr9:115635662 SNX30 -0.57 -5.77 -0.3 1.87e-8 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs2070488 0.699 rs6599205 chr3:38529440 C/G cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.68 11.37 0.53 1.7e-25 Electrocardiographic conduction measures; CRC trans rs875971 0.660 rs2191268 chr7:66110224 C/T cg17274400 chr12:8234945 NECAP1 -0.39 -6.05 -0.32 3.9e-9 Aortic root size; CRC cis rs12410462 0.681 rs4131980 chr1:227572123 A/G cg23173402 chr1:227635558 NA 0.69 6.51 0.34 2.83e-10 Major depressive disorder; CRC cis rs6912958 1.000 rs6454630 chr6:88171357 C/G cg08069147 chr6:88032118 GJB7;C6orf162 0.56 8.58 0.43 3.76e-16 Monocyte percentage of white cells; CRC trans rs459571 0.629 rs441233 chr9:136876021 A/G cg10765909 chr12:53715428 AAAS 0.52 6.81 0.35 4.55e-11 Platelet distribution width; CRC cis rs3820068 0.603 rs72647120 chr1:15956769 G/T cg27534772 chr1:16042836 PLEKHM2 0.54 10.43 0.5 3.46e-22 Systolic blood pressure; CRC cis rs2019137 0.936 rs3811059 chr2:113962071 C/T cg21610815 chr2:113994035 PAX8;LOC654433;LOC440839 -0.46 -6.53 -0.34 2.53e-10 Lymphocyte counts; CRC cis rs116095464 0.558 rs12173244 chr5:269524 G/A cg22857025 chr5:266934 NA -1.24 -16.72 -0.68 7.21e-46 Breast cancer; CRC cis rs11098499 0.865 rs4507344 chr4:120307485 C/A cg09307838 chr4:120376055 NA 0.71 10.93 0.52 6.41e-24 Corneal astigmatism; CRC cis rs116095464 0.558 rs9312957 chr5:202194 C/T cg22496380 chr5:211416 CCDC127 -0.89 -9.14 -0.45 6.41e-18 Breast cancer; CRC cis rs2228479 0.850 rs17233448 chr16:89816424 G/T cg19635926 chr16:89946313 TCF25 0.66 5.97 0.31 6.1e-9 Skin colour saturation; CRC cis rs2032447 0.517 rs7767546 chr6:25904067 T/C cg15691649 chr6:25882328 NA -0.53 -7.06 -0.36 9.89e-12 Intelligence (multi-trait analysis); CRC cis rs780096 0.505 rs12475426 chr2:27599132 G/A cg17158414 chr2:27665306 KRTCAP3 -0.28 -5.99 -0.31 5.63e-9 Total body bone mineral density; CRC cis rs1278769 0.735 rs12585036 chr13:113535741 C/T cg00823993 chr13:113535758 ATP11A 0.66 8.8 0.44 8.1e-17 Interstitial lung disease; CRC cis rs13631 0.697 rs1018330 chr9:139980385 A/C cg15396367 chr9:139972779 UAP1L1 0.55 8.64 0.43 2.42e-16 Cerebrospinal fluid biomarker levels; CRC trans rs2303319 0.504 rs62187656 chr2:162487699 A/G cg13490827 chr1:46269305 MAST2 -0.72 -6.21 -0.32 1.6e-9 Cognitive function; CRC cis rs4819052 0.851 rs4818768 chr21:46659818 T/A cg19498844 chr21:46707878 POFUT2;LOC642852 0.77 10.99 0.52 3.97e-24 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs7927592 0.913 rs67605986 chr11:68300955 C/T cg16797656 chr11:68205561 LRP5 0.36 5.75 0.3 2.08e-8 Total body bone mineral density; CRC cis rs4555082 0.834 rs2816607 chr14:105718385 A/T cg13114125 chr14:105738426 BRF1 -0.85 -12.39 -0.56 3.3e-29 Mean platelet volume;Platelet distribution width; CRC cis rs7267979 0.764 rs2474767 chr20:25246733 T/C cg24626310 chr20:25276739 ABHD12;PYGB 0.35 5.8 0.3 1.56e-8 Liver enzyme levels (alkaline phosphatase); CRC cis rs6951245 0.554 rs76243429 chr7:1152543 C/T cg26224354 chr7:1096374 C7orf50;GPR146 -0.6 -8.03 -0.4 1.79e-14 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs4689388 0.856 rs10016157 chr4:6294414 T/C cg25554036 chr4:6271136 WFS1 0.53 8.7 0.43 1.59e-16 Type 2 diabetes and other traits;Type 2 diabetes; CRC cis rs294883 0.739 rs905686 chr6:159733130 A/G cg14500486 chr6:159655392 FNDC1 -0.36 -6.05 -0.32 3.83e-9 Coronary artery disease; CRC cis rs12451471 0.559 rs34746710 chr17:78079224 G/A cg18972013 chr17:78078605 GAA -0.39 -5.78 -0.3 1.77e-8 Plateletcrit;Mean corpuscular hemoglobin concentration; CRC cis rs2840044 1.000 rs225251 chr17:33951228 A/C cg05299278 chr17:33885742 SLFN14 0.38 5.68 0.3 2.95e-8 Response to radiotherapy in cancer (late toxicity); CRC cis rs8063761 1.000 rs8063761 chr16:90027626 A/T cg08547343 chr16:90038815 CENPBD1;AFG3L1 0.48 6.53 0.34 2.48e-10 Squamous cell carcinoma; CRC cis rs2832191 0.550 rs66484040 chr21:30511691 G/A cg24692254 chr21:30365293 RNF160 -0.57 -8.37 -0.42 1.64e-15 Dental caries; CRC cis rs7208859 0.623 rs75136574 chr17:28934549 C/A cg13385521 chr17:29058706 SUZ12P 0.62 6.66 0.34 1.13e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs6502050 0.835 rs8065556 chr17:80091176 G/C cg19223190 chr17:80058835 NA 0.39 6.32 0.33 8.75e-10 Life satisfaction; CRC cis rs1862618 0.853 rs252904 chr5:56118733 A/T cg22800045 chr5:56110881 MAP3K1 0.51 5.75 0.3 2.03e-8 Initial pursuit acceleration; CRC cis rs9467160 1.000 rs9467158 chr6:24441215 G/A cg20631270 chr6:24437470 GPLD1 0.49 6.32 0.33 8.75e-10 Liver enzyme levels; CRC cis rs2032447 0.869 rs199752 chr6:26012875 C/T cg04800585 chr6:26043546 HIST1H2BB 0.58 8.48 0.42 7.81e-16 Intelligence (multi-trait analysis); CRC cis rs2032447 0.898 rs807205 chr6:26075035 C/G cg12588279 chr6:26043732 HIST1H2BB 0.43 6.2 0.32 1.73e-9 Intelligence (multi-trait analysis); CRC cis rs6893300 0.542 rs3797774 chr5:179193970 C/T cg14593053 chr5:179126677 CANX 0.49 7.82 0.4 7.35e-14 Resting heart rate; CRC cis rs11148252 0.595 rs4885117 chr13:53153027 T/C cg02158880 chr13:53174818 NA 0.55 8.85 0.44 5.54e-17 Lewy body disease; CRC cis rs853679 0.598 rs9380054 chr6:28067537 G/A cg21251018 chr6:28226885 NKAPL 0.48 6.26 0.33 1.17e-9 Depression; CRC cis rs4975709 0.569 rs1684965 chr5:1865248 A/G cg20790798 chr5:1857306 NA -0.41 -6.14 -0.32 2.44e-9 Cardiovascular disease risk factors; CRC cis rs514406 0.722 rs7552139 chr1:53387379 G/C cg25767906 chr1:53392781 SCP2 -0.47 -7.47 -0.38 7.37e-13 Monocyte count; CRC cis rs66573146 1.000 rs56178503 chr4:6961748 C/T cg00086871 chr4:6988644 TBC1D14 0.95 7.23 0.37 3.4e-12 Granulocyte percentage of myeloid white cells; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg12951224 chr8:38126910 PPAPDC1B 0.47 6.02 0.31 4.7e-9 Thyroid stimulating hormone; CRC trans rs4942242 0.574 rs9533557 chr13:44197487 C/G cg19169023 chr15:41853346 TYRO3 0.58 8.13 0.41 8.74e-15 Response to tocilizumab in rheumatoid arthritis; CRC cis rs7666738 0.830 rs6854919 chr4:98947326 C/T cg17366294 chr4:99064904 C4orf37 0.4 6.46 0.34 3.67e-10 Colonoscopy-negative controls vs population controls; CRC cis rs1552244 0.882 rs7633769 chr3:10020622 C/T cg02579736 chr3:10068473 FANCD2;CIDECP 0.86 11.36 0.53 1.81e-25 Alzheimer's disease; CRC cis rs2839186 0.770 rs2839171 chr21:47673247 C/T cg11766577 chr21:47581405 C21orf56 0.46 7.33 0.37 1.8e-12 Testicular germ cell tumor; CRC cis rs3736485 0.789 rs6493499 chr15:51812842 T/A cg08986416 chr15:51914746 DMXL2 -0.49 -7.07 -0.36 9.19e-12 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs17767392 0.609 rs60526802 chr14:71680078 C/T cg13720639 chr14:72061746 SIPA1L1 -0.51 -6.19 -0.32 1.75e-9 Mitral valve prolapse; CRC cis rs9457247 1.000 rs405553 chr6:167395058 A/G cg23791538 chr6:167370224 RNASET2 -0.38 -5.97 -0.31 6.08e-9 Crohn's disease; CRC cis rs28386778 0.700 rs11079515 chr17:62005645 C/G cg22520471 chr17:61851767 DDX42;CCDC47 -0.56 -8.22 -0.41 4.64e-15 Prudent dietary pattern; CRC cis rs9814567 0.752 rs7623567 chr3:134330976 T/C cg06109529 chr3:134205091 CEP63;ANAPC13 -0.67 -9.58 -0.47 2.53e-19 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs2032447 0.714 rs129129 chr6:25961029 A/G cg04800585 chr6:26043546 HIST1H2BB 0.49 7.45 0.38 8.17e-13 Intelligence (multi-trait analysis); CRC cis rs9858542 0.953 rs9827708 chr3:49649989 C/G cg07274523 chr3:49395745 GPX1 0.45 5.73 0.3 2.32e-8 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC trans rs916888 0.610 rs199536 chr17:44820425 T/C cg22433210 chr17:43662623 NA -0.61 -7.73 -0.39 1.36e-13 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs6866344 0.570 rs1079487 chr5:178136005 G/A cg03877680 chr5:178157825 ZNF354A 0.75 10.92 0.52 6.53e-24 Neutrophil percentage of white cells; CRC cis rs62229266 0.659 rs7275820 chr21:37409414 G/A cg12218747 chr21:37451666 NA -0.36 -6.2 -0.32 1.71e-9 Mitral valve prolapse; CRC cis rs425277 0.585 rs3107157 chr1:2061969 A/G cg04315214 chr1:2043799 PRKCZ 0.5 8.82 0.44 6.58e-17 Height; CRC cis rs12971120 0.891 rs3794955 chr18:72174827 C/T cg26446133 chr18:72167187 CNDP2 -0.75 -11.07 -0.52 2.03e-24 Refractive error; CRC cis rs4664308 1.000 rs6759836 chr2:160912802 C/T cg03641300 chr2:160917029 PLA2R1 -0.76 -12.62 -0.57 4.89e-30 Idiopathic membranous nephropathy; CRC cis rs8077889 0.871 rs72836549 chr17:41904360 G/T cg16892393 chr17:41919603 NA 0.6 8.63 0.43 2.71e-16 Triglycerides; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg21570168 chr14:102226945 PPP2R5C 0.39 6.55 0.34 2.24e-10 Liver disease severity in Alagille syndrome; CRC trans rs2727020 0.615 rs35423199 chr11:49514914 T/C cg03929089 chr4:120376271 NA -0.92 -17.39 -0.69 1.63e-48 Coronary artery disease; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg08805160 chr11:8704501 RPL27A;SNORA3 -0.44 -6.99 -0.36 1.52e-11 Myopia (pathological); CRC cis rs17253792 0.822 rs28481586 chr14:56053863 C/G cg01858014 chr14:56050164 KTN1 -0.88 -7.83 -0.4 6.57e-14 Putamen volume; CRC cis rs939584 1.000 rs13397165 chr2:653354 G/A cg03610516 chr2:642275 NA -0.41 -5.65 -0.3 3.43e-8 Body mass index; CRC cis rs6089584 0.888 rs6089623 chr20:60615759 A/G cg23262073 chr20:60523788 NA -0.48 -7.42 -0.38 1.03e-12 Body mass index; CRC cis rs936229 0.705 rs936227 chr15:75131959 A/G cg09165964 chr15:75287851 SCAMP5 0.44 6.84 0.35 3.94e-11 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); CRC cis rs6163 0.727 rs284854 chr10:104574562 T/G cg04362960 chr10:104952993 NT5C2 -0.54 -7.93 -0.4 3.41e-14 Waist circumference;Hip circumference; CRC cis rs863345 0.604 rs2051451 chr1:158464265 A/C cg12129480 chr1:158549410 OR10X1 -0.3 -6.26 -0.33 1.17e-9 Pneumococcal bacteremia; CRC cis rs9372498 0.536 rs17080292 chr6:118850266 A/G cg10217327 chr6:118973057 C6orf204 0.51 5.8 0.3 1.59e-8 Diastolic blood pressure; CRC cis rs2742417 0.603 rs2742370 chr3:45782098 T/C cg04837898 chr3:45731254 SACM1L -0.48 -7.72 -0.39 1.45e-13 Response to anti-depressant treatment in major depressive disorder; CRC cis rs7666738 0.830 rs13139078 chr4:99020774 C/T cg17366294 chr4:99064904 C4orf37 0.43 7.29 0.37 2.28e-12 Colonoscopy-negative controls vs population controls; CRC cis rs910316 0.935 rs175448 chr14:75591071 G/A cg11812906 chr14:75593930 NEK9 -0.57 -8.96 -0.44 2.49e-17 Height; CRC cis rs875971 0.862 rs1643375 chr7:65872677 T/C cg11764359 chr7:65958608 NA 0.59 9.08 0.45 1.06e-17 Aortic root size; CRC trans rs4295623 0.553 rs34962960 chr8:11594597 G/A cg27411982 chr8:10470053 RP1L1 -0.4 -6.33 -0.33 8.23e-10 Morning vs. evening chronotype; CRC cis rs1448094 0.511 rs61930035 chr12:86153695 G/A cg18827107 chr12:86230957 RASSF9 -0.41 -6.18 -0.32 1.89e-9 Major depressive disorder; CRC trans rs12439619 1.000 rs35152457 chr15:82546548 G/A cg04831495 chr15:85060580 GOLGA6L5 -0.47 -6.69 -0.35 9.59e-11 Intelligence (multi-trait analysis); CRC trans rs6550704 0.687 rs9865314 chr3:22634337 A/G cg25533220 chr19:2328480 SPPL2B;LSM7 -0.43 -6.42 -0.33 4.67e-10 Daytime sleep phenotypes; CRC cis rs2153535 0.580 rs9505450 chr6:8469902 C/T cg21535247 chr6:8435926 SLC35B3 0.5 7.53 0.38 4.89e-13 Motion sickness; CRC trans rs3749237 1.000 rs2291542 chr3:49751585 C/T cg21665057 chr3:196295764 WDR53;FBXO45 0.55 8.01 0.4 2.07e-14 Resting heart rate; CRC cis rs4665809 0.838 rs6546780 chr2:26352857 T/C cg22920501 chr2:26401640 FAM59B -0.55 -7.55 -0.38 4.36e-13 Gut microbiome composition (summer); CRC trans rs875971 0.545 rs7811204 chr7:65852200 G/A cg02869306 chr7:64672164 INTS4L1 -0.43 -6.19 -0.32 1.82e-9 Aortic root size; CRC cis rs7429990 0.901 rs9825114 chr3:48138082 A/G cg11946769 chr3:48343235 NME6 -0.5 -6.6 -0.34 1.69e-10 Educational attainment (years of education); CRC cis rs7095944 0.614 rs12570348 chr10:126438963 A/C cg08799069 chr10:126477246 METTL10 0.43 6.52 0.34 2.57e-10 Asthma; CRC cis rs10986311 0.802 rs7045589 chr9:127110354 C/T cg14243010 chr9:127117328 LOC100129034;PSMB7 0.39 5.97 0.31 6.04e-9 Vitiligo; CRC trans rs9420907 0.748 rs9419958 chr10:105675946 T/C ch.7.2986028F chr7:141887997 LOC100124692 -0.54 -5.99 -0.31 5.49e-9 Telomere length; CRC trans rs7580658 0.614 rs7585198 chr2:127962635 C/T cg17105206 chr16:67211972 KIAA0895L -0.4 -6.08 -0.32 3.32e-9 Protein C levels; CRC cis rs9648716 0.935 rs1267647 chr7:140486288 C/T cg10747023 chr7:140774559 NA 0.44 5.67 0.3 3.14e-8 Type 2 diabetes; CRC cis rs8141529 0.702 rs469990 chr22:29304200 A/T cg15103426 chr22:29168792 CCDC117 0.49 6.95 0.36 1.93e-11 Lymphocyte counts; CRC cis rs733592 0.504 rs2261608 chr12:48721634 A/T cg21466736 chr12:48725269 NA -0.54 -8.55 -0.43 4.87e-16 Plateletcrit; CRC cis rs6701037 0.625 rs72719370 chr1:175128536 G/C cg00321850 chr1:175162397 KIAA0040 -0.4 -6.69 -0.35 9.5e-11 Alcohol dependence; CRC cis rs2354432 0.607 rs10900350 chr1:146828017 T/G cg25205988 chr1:146714368 CHD1L 1.14 10.04 0.48 7.37e-21 Mitochondrial DNA levels; CRC cis rs554111 0.891 rs604645 chr1:21043926 T/C cg00373020 chr1:21041521 KIF17 0.41 6.33 0.33 8.04e-10 Facial morphology (factor 17, height of vermillion upper lip); CRC cis rs1448094 0.556 rs2061686 chr12:86170951 C/T cg02569458 chr12:86230093 RASSF9 -0.45 -7.74 -0.39 1.26e-13 Major depressive disorder; CRC cis rs11608355 0.960 rs11066526 chr12:109854476 G/C cg19025524 chr12:109796872 NA -0.47 -6.78 -0.35 5.7e-11 Neuroticism; CRC cis rs938554 0.915 rs4697913 chr4:9941262 C/T cg00071950 chr4:10020882 SLC2A9 -0.41 -5.62 -0.3 4.15e-8 Blood metabolite levels; CRC cis rs9611565 0.559 rs132768 chr22:42013523 C/A cg06481639 chr22:41940642 POLR3H 0.52 5.63 0.3 3.81e-8 Vitiligo; CRC cis rs10504229 0.683 rs7843919 chr8:58130792 T/C cg02290350 chr8:58132656 NA -0.58 -8.16 -0.41 7.29e-15 Developmental language disorder (linguistic errors); CRC cis rs4713118 0.662 rs175954 chr6:28011585 A/G cg23161317 chr6:28129485 ZNF389 0.45 6.02 0.31 4.77e-9 Parkinson's disease; CRC cis rs9443645 0.901 rs2050660 chr6:79734726 C/T cg05283184 chr6:79620031 NA -0.63 -9.97 -0.48 1.21e-20 Intelligence (multi-trait analysis); CRC cis rs3733346 0.529 rs6842493 chr4:914638 T/C cg20916646 chr4:852691 GAK 0.47 6.95 0.36 1.93e-11 Sjögren's syndrome; CRC cis rs9304742 0.962 rs1044467 chr19:53452769 A/G cg09915433 chr19:53449742 NA -0.67 -10.28 -0.49 1.07e-21 Psoriasis; CRC cis rs7258465 0.931 rs1560119 chr19:18573675 A/G cg06953865 chr19:18549723 ISYNA1 -0.38 -5.81 -0.31 1.45e-8 Breast cancer; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg04470066 chr3:159943320 LOC401097 0.31 6.03 0.32 4.35e-9 Liver disease severity in Alagille syndrome; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg00197636 chr8:57906363 IMPAD1 0.39 6.13 0.32 2.53e-9 Liver disease severity in Alagille syndrome; CRC cis rs2839186 0.739 rs2280958 chr21:47642016 C/T cg13126279 chr21:47581558 C21orf56 -0.52 -8.51 -0.42 6.27e-16 Testicular germ cell tumor; CRC cis rs3733585 0.577 rs5014939 chr4:9953253 T/A cg00071950 chr4:10020882 SLC2A9 -0.55 -9.74 -0.47 7.09e-20 Cleft plate (environmental tobacco smoke interaction); CRC cis rs12497850 0.931 rs1134591 chr3:48972892 C/T cg07636037 chr3:49044803 WDR6 0.99 17.96 0.7 9.34e-51 Parkinson's disease; CRC cis rs8141529 0.748 rs6005936 chr22:29289250 T/C cg15103426 chr22:29168792 CCDC117 0.52 7.32 0.37 1.89e-12 Lymphocyte counts; CRC cis rs7927592 0.956 rs7106259 chr11:68298512 T/G cg16797656 chr11:68205561 LRP5 0.37 6.02 0.32 4.63e-9 Total body bone mineral density; CRC cis rs57221529 0.766 rs17497684 chr5:558307 T/C cg17948913 chr5:572064 NA 0.53 6.12 0.32 2.72e-9 Lung disease severity in cystic fibrosis; CRC cis rs812925 0.502 rs2084318 chr2:61652601 C/T cg10580144 chr2:61372316 C2orf74 -0.31 -6.72 -0.35 8.16e-11 Immature fraction of reticulocytes; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg04212729 chr14:65171037 PLEKHG3 0.46 6.52 0.34 2.63e-10 Response to antipsychotic treatment; CRC trans rs1005277 0.579 rs1985707 chr10:38434098 C/T cg23533926 chr12:111358616 MYL2 -0.52 -7.87 -0.4 5.18e-14 Extrinsic epigenetic age acceleration; CRC trans rs4714291 0.832 rs6917417 chr6:40104628 T/C cg02267698 chr19:7991119 CTXN1 -0.52 -7.02 -0.36 1.26e-11 Strep throat; CRC cis rs57994353 0.865 rs35857370 chr9:139354097 G/A cg14119001 chr9:139324193 INPP5E -0.44 -6.23 -0.32 1.46e-9 Eosinophil counts;Cutaneous squamous cell carcinoma; CRC cis rs4713118 0.513 rs149959 chr6:28013854 T/C cg21251018 chr6:28226885 NKAPL 0.48 7.52 0.38 5.21e-13 Parkinson's disease; CRC cis rs8018808 0.875 rs11159258 chr14:77880593 T/C cg20045696 chr14:77926864 AHSA1 0.38 5.86 0.31 1.1e-8 Myeloid white cell count; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg24087235 chr1:54665621 CYB5RL;MRPL37 0.52 7.52 0.38 5.4e-13 Response to antipsychotic treatment; CRC cis rs9322193 0.923 rs9322200 chr6:149951214 G/A cg07701084 chr6:150067640 NUP43 0.53 7.87 0.4 5.09e-14 Lung cancer; CRC cis rs6840360 0.967 rs7667197 chr4:152613952 G/A cg09659197 chr4:152720779 NA 0.52 11.43 0.53 1.07e-25 Intelligence (multi-trait analysis); CRC cis rs4523957 0.547 rs11078856 chr17:2092064 G/A cg16513277 chr17:2031491 SMG6 -0.58 -9.9 -0.48 2.08e-20 Autism spectrum disorder or schizophrenia;Schizophrenia; CRC trans rs12438356 0.571 rs6494785 chr15:69436267 C/T cg25446197 chr4:25235616 PI4K2B 0.54 6.16 0.32 2.11e-9 CTACK levels; CRC cis rs2576037 0.526 rs3892820 chr18:44479558 A/G cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.54 9.21 0.45 4.05e-18 Personality dimensions; CRC cis rs7662987 0.517 rs1311615 chr4:100012261 G/A cg12011299 chr4:100065546 ADH4 0.49 9.14 0.45 6.42e-18 Smoking initiation; CRC cis rs6121246 0.529 rs6060210 chr20:30187681 C/T cg13852791 chr20:30311386 BCL2L1 0.6 8.21 0.41 5.04e-15 Mean corpuscular hemoglobin; CRC cis rs7772486 0.754 rs9399561 chr6:145955687 C/G cg23711669 chr6:146136114 FBXO30 0.76 12.99 0.58 2e-31 Lobe attachment (rater-scored or self-reported); CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg18876494 chr12:69004196 RAP1B -0.4 -5.99 -0.31 5.38e-9 Myopia (pathological); CRC cis rs4974559 0.739 rs28429103 chr4:1320023 G/A cg02980000 chr4:1222292 CTBP1 0.76 8.36 0.42 1.74e-15 Systolic blood pressure; CRC cis rs172166 0.694 rs203892 chr6:28067196 T/C cg03623178 chr6:28175578 NA 0.8 11.88 0.55 2.41e-27 Cardiac Troponin-T levels; CRC cis rs1552244 0.572 rs2054478 chr3:10172211 C/T cg10729496 chr3:10149963 C3orf24 0.51 5.9 0.31 8.81e-9 Alzheimer's disease; CRC cis rs7666738 0.830 rs13125537 chr4:98978428 A/G cg05340658 chr4:99064831 C4orf37 0.6 9.37 0.46 1.19e-18 Colonoscopy-negative controls vs population controls; CRC cis rs7945705 0.967 rs10769970 chr11:8917937 A/G cg00186954 chr11:8933980 ST5;C11orf17 0.46 7.11 0.36 7.38e-12 Hemoglobin concentration; CRC cis rs2408955 0.522 rs11168408 chr12:48498327 G/A cg15465823 chr12:48382534 COL2A1 -0.38 -6.23 -0.32 1.46e-9 Glycated hemoglobin levels; CRC cis rs13191362 0.935 rs13205279 chr6:162945030 C/T cg21926612 chr6:163149169 PACRG;PARK2 0.79 9.55 0.47 3.09e-19 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs7309 0.870 rs2358016 chr2:162007430 C/G cg21518248 chr2:162101506 NA -0.43 -6.29 -0.33 9.89e-10 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Educational attainment; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg22255355 chr19:58838374 ZSCAN22 0.38 6.02 0.31 4.71e-9 Liver disease severity in Alagille syndrome; CRC cis rs10504229 0.728 rs72650861 chr8:58153273 T/C cg02725872 chr8:58115012 NA -0.57 -9.07 -0.45 1.09e-17 Developmental language disorder (linguistic errors); CRC cis rs3733585 0.605 rs4697708 chr4:10121189 A/G cg00071950 chr4:10020882 SLC2A9 -0.58 -9.35 -0.46 1.43e-18 Cleft plate (environmental tobacco smoke interaction); CRC cis rs60843830 1.000 rs62114548 chr2:274672 C/G cg25945732 chr2:264204 ACP1;SH3YL1 0.73 11.61 0.54 2.3e-26 Spherical equivalent (joint analysis main effects and education interaction); CRC cis rs10078 0.571 rs2671890 chr5:456457 A/G cg26072250 chr5:443457 EXOC3;C5orf55 0.59 5.84 0.31 1.23e-8 Fat distribution (HIV); CRC cis rs11212617 1.000 rs227093 chr11:108233939 T/A cg12106634 chr11:108092400 ATM;NPAT 0.39 5.74 0.3 2.16e-8 Response to metformin in type 2 diabetes (glycemic); CRC cis rs72615157 0.539 rs4729575 chr7:99686873 G/T cg22004693 chr7:99632812 ZKSCAN1 0.4 6.06 0.32 3.69e-9 Lung function (FEV1/FVC); CRC cis rs7615952 0.599 rs1875683 chr3:125732481 C/G cg18479299 chr3:125709523 NA -0.55 -6.53 -0.34 2.54e-10 Blood pressure (smoking interaction); CRC cis rs736801 0.754 rs2706336 chr5:131799961 T/C cg14196790 chr5:131705035 SLC22A5 -0.35 -5.77 -0.3 1.87e-8 Breast cancer;Mosquito bite size; CRC trans rs877282 0.947 rs957642 chr10:773966 C/T cg22713356 chr15:30763199 NA 1.1 14.29 0.62 2.3e-36 Uric acid levels; CRC cis rs35306767 0.903 rs35370435 chr10:898205 T/C cg20503657 chr10:835505 NA 1.21 14.81 0.63 2.26e-38 Eosinophil percentage of granulocytes; CRC cis rs72945132 0.678 rs7113595 chr11:70236819 T/C cg14191688 chr11:70257035 CTTN 0.57 7.86 0.4 5.55e-14 Coronary artery disease; CRC trans rs7976838 0.908 rs34790713 chr12:60140993 G/A cg16974014 chr22:22007515 MIR130B 0.49 6.0 0.31 5.31e-9 Response to zileuton treatment in asthma (FEV1 change interaction); CRC cis rs12760731 0.623 rs1985761 chr1:178438645 A/G cg00404053 chr1:178313656 RASAL2 0.69 8.61 0.43 3.05e-16 Obesity-related traits; CRC cis rs6582630 0.555 rs10880544 chr12:38473464 G/C cg26384229 chr12:38710491 ALG10B 0.72 10.09 0.49 4.78e-21 Drug-induced liver injury (flucloxacillin); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg17684478 chr11:118842230 FOXR1 0.4 6.49 0.34 3.14e-10 Liver disease severity in Alagille syndrome; CRC cis rs7113874 0.550 rs2044464 chr11:8559695 G/A cg20771178 chr11:8615675 STK33 -0.35 -5.85 -0.31 1.18e-8 Body mass index in physically active individuals;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs172166 0.561 rs149976 chr6:27987776 C/T cg12172441 chr6:28176163 NA -0.45 -6.52 -0.34 2.72e-10 Cardiac Troponin-T levels; CRC cis rs3750082 0.889 rs6462432 chr7:32935524 C/T cg05721444 chr7:32995514 FKBP9 0.5 7.85 0.4 5.98e-14 Glomerular filtration rate (creatinine); CRC cis rs6700896 0.931 rs12043644 chr1:66147348 A/G cg04111102 chr1:66153794 NA 0.34 5.8 0.3 1.56e-8 C-reactive protein;Mean corpuscular volume;Mean corpuscular hemoglobin; CRC cis rs9928842 0.882 rs11641896 chr16:75300179 T/C cg08657710 chr16:75258780 CTRB1 -0.57 -6.48 -0.34 3.28e-10 Alcoholic chronic pancreatitis; CRC trans rs11039798 0.614 rs116427493 chr11:48776141 C/T cg15704280 chr7:45808275 SEPT13 0.62 6.04 0.32 4.27e-9 Axial length; CRC trans rs656319 0.580 rs13272793 chr8:10002027 C/T cg06636001 chr8:8085503 FLJ10661 -0.46 -6.75 -0.35 6.75e-11 Myopia (pathological); CRC cis rs12477438 0.520 rs11123762 chr2:99727789 T/C cg26064155 chr2:99771622 LIPT1;TSGA10 0.89 16.27 0.67 4.24e-44 Chronic sinus infection; CRC cis rs270601 0.770 rs4361510 chr5:131599647 C/T cg22638593 chr5:131593259 PDLIM4 0.48 9.05 0.45 1.28e-17 Acylcarnitine levels; CRC cis rs7659604 0.518 rs17452156 chr4:122733623 T/C cg06713675 chr4:122721982 EXOSC9 -0.52 -8.31 -0.42 2.63e-15 Type 2 diabetes; CRC cis rs1799949 0.602 rs8176257 chr17:41216205 G/T cg05368731 chr17:41323189 NBR1 0.64 8.5 0.42 6.82e-16 Menopause (age at onset); CRC trans rs10242455 0.702 rs17854665 chr7:99050039 G/A cg09045935 chr12:6379348 NA 1.13 9.24 0.45 3.24e-18 Blood metabolite levels; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg23953233 chr12:53574539 ZNF740;CSAD 0.37 5.96 0.31 6.54e-9 Liver disease severity in Alagille syndrome; CRC cis rs2089162 1 rs2089162 chr15:78739763 A/G cg18825076 chr15:78729989 IREB2 -0.51 -7.63 -0.39 2.54e-13 Post bronchodilator FEV1/FVC ratio in COPD;Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; CRC cis rs274567 0.602 rs272853 chr5:131688561 A/G cg12564285 chr5:131593104 PDLIM4 0.43 7.45 0.38 8.16e-13 Blood metabolite levels; CRC cis rs7605827 0.930 rs13007310 chr2:15710058 A/G cg19274914 chr2:15703543 NA -0.38 -5.79 -0.3 1.67e-8 Educational attainment (years of education); CRC trans rs2303319 0.504 rs1023835 chr2:162593973 A/G cg25193742 chr10:104614220 C10orf32 -0.77 -6.51 -0.34 2.87e-10 Cognitive function; CRC cis rs11122272 0.766 rs2486732 chr1:231531476 A/C cg06096015 chr1:231504339 EGLN1 0.4 5.99 0.31 5.47e-9 Hemoglobin concentration; CRC cis rs172166 0.637 rs1225592 chr6:28150242 G/A cg02683197 chr6:28174875 NA 0.75 11.02 0.52 3.04e-24 Cardiac Troponin-T levels; CRC cis rs3087591 1.000 rs6505235 chr17:29688603 C/A cg24425628 chr17:29625626 OMG;NF1 -0.86 -16.65 -0.68 1.37e-45 Hip circumference; CRC cis rs875971 0.545 rs73152714 chr7:65999628 G/A cg03233332 chr7:66118400 NA -0.43 -6.03 -0.32 4.35e-9 Aortic root size; CRC cis rs7666738 0.830 rs4401456 chr4:98959902 C/T cg05340658 chr4:99064831 C4orf37 0.61 9.54 0.47 3.45e-19 Colonoscopy-negative controls vs population controls; CRC cis rs11677370 0.561 rs10084170 chr2:3820204 G/C cg17052675 chr2:3827356 NA -0.67 -11.6 -0.54 2.61e-26 Type 2 diabetes; CRC cis rs270601 0.721 rs270621 chr5:131605821 C/A cg12564285 chr5:131593104 PDLIM4 0.55 9.57 0.47 2.62e-19 Acylcarnitine levels; CRC cis rs6032067 0.929 rs6017503 chr20:43815103 G/A cg10761708 chr20:43804764 PI3 0.5 5.69 0.3 2.77e-8 Blood protein levels; CRC cis rs10256972 0.616 rs4585652 chr7:1145396 A/G cg22907277 chr7:1156413 C7orf50 0.7 10.66 0.51 5.29e-23 Longevity;Endometriosis; CRC cis rs6502050 0.835 rs7502676 chr17:80093433 C/G cg19223190 chr17:80058835 NA 0.4 6.53 0.34 2.45e-10 Life satisfaction; CRC cis rs12477438 0.735 rs12474477 chr2:99690408 G/T cg14399236 chr2:99771627 LIPT1;TSGA10 -0.73 -10.25 -0.49 1.37e-21 Chronic sinus infection; CRC cis rs875971 0.756 rs2901210 chr7:66017505 G/A cg12463550 chr7:65579703 CRCP -0.46 -6.21 -0.32 1.59e-9 Aortic root size; CRC cis rs2842992 0.830 rs1475123 chr6:160178007 A/G cg11366901 chr6:160182831 ACAT2 0.9 13.32 0.59 1.14e-32 Age-related macular degeneration (geographic atrophy); CRC cis rs9911578 1.000 rs2079703 chr17:56603978 G/A cg12560992 chr17:57184187 TRIM37 -0.91 -17.1 -0.69 2.31e-47 Intelligence (multi-trait analysis); CRC cis rs9368481 0.594 rs2636425 chr6:26799460 A/G cg05192639 chr6:26864778 GUSBL1 0.34 6.37 0.33 6.34e-10 Autism spectrum disorder or schizophrenia; CRC cis rs7973719 0.868 rs6486910 chr12:7356479 G/A cg07052231 chr12:7363540 PEX5 0.52 8.4 0.42 1.39e-15 IgG glycosylation; CRC cis rs853679 0.517 rs56310871 chr6:28044482 A/G cg12172441 chr6:28176163 NA 0.59 7.12 0.37 6.82e-12 Depression; CRC cis rs7223966 0.961 rs17631783 chr17:61687600 A/G cg23090583 chr17:61904693 PSMC5;FTSJ3 -0.5 -5.91 -0.31 8.45e-9 Hip circumference adjusted for BMI;Body mass index; CRC cis rs2281845 0.533 rs10753891 chr1:201100482 A/G cg08885800 chr1:201084119 NA 0.4 6.31 0.33 9.18e-10 Permanent tooth development; CRC cis rs6951245 1.000 rs79422648 chr7:1080241 T/C cg08132940 chr7:1081526 C7orf50 -0.54 -5.64 -0.3 3.65e-8 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs875971 0.545 rs73378304 chr7:65640747 G/A cg11764359 chr7:65958608 NA 0.51 6.84 0.35 3.93e-11 Aortic root size; CRC cis rs12692738 0.526 rs355833 chr2:165617089 G/T cg03182029 chr2:165697222 COBLL1 0.48 5.66 0.3 3.32e-8 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);Waist-to-hip ratio adjusted for BMI in non-smokers;Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction);Waist-to-hip ratio adjusted for body mass index; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg11742202 chr6:74364667 SLC17A5 0.29 5.96 0.31 6.32e-9 Liver disease severity in Alagille syndrome; CRC trans rs2303319 0.504 rs62189043 chr2:162608466 A/T cg03774468 chr3:140950104 ACPL2 -0.65 -6.07 -0.32 3.61e-9 Cognitive function; CRC cis rs13256369 0.802 rs11249885 chr8:8562008 C/T cg17143192 chr8:8559678 CLDN23 0.54 7.14 0.37 5.92e-12 Obesity-related traits; CRC cis rs4332037 0.539 rs55790766 chr7:2021248 C/T cg23422044 chr7:1970798 MAD1L1 -0.6 -7.37 -0.38 1.35e-12 Bipolar disorder; CRC cis rs1552244 1.000 rs9827740 chr3:10120531 T/C cg00166722 chr3:10149974 C3orf24 0.67 9.26 0.45 2.71e-18 Alzheimer's disease; CRC cis rs673253 0.686 rs943513 chr1:44035472 G/A cg10881128 chr1:44031826 PTPRF 0.2 5.66 0.3 3.26e-8 Intelligence (multi-trait analysis); CRC cis rs972578 1.000 rs5759060 chr22:43361804 T/C cg01576275 chr22:43409880 NA -0.45 -7.27 -0.37 2.62e-12 Mean platelet volume; CRC cis rs7202877 0.561 rs7202083 chr16:75383727 G/T cg03315344 chr16:75512273 CHST6 0.58 5.94 0.31 7.28e-9 Type 2 diabetes;Type 1 diabetes; CRC cis rs7524258 0.868 rs6693725 chr1:7307810 G/T cg07173049 chr1:7289937 CAMTA1 0.59 9.89 0.48 2.31e-20 Tourette's syndrome or obsessive-compulsive disorder; CRC cis rs763121 0.819 rs5757169 chr22:39003495 G/A cg06544989 chr22:39130855 UNC84B 0.46 7.37 0.38 1.43e-12 Menopause (age at onset); CRC cis rs10504229 0.728 rs72650856 chr8:58152695 C/T cg22535103 chr8:58192502 C8orf71 -0.68 -8.37 -0.42 1.72e-15 Developmental language disorder (linguistic errors); CRC cis rs3849570 0.615 rs35779564 chr3:81982771 G/A cg07356753 chr3:81810745 GBE1 -0.52 -7.15 -0.37 5.51e-12 Waist circumference;Body mass index; CRC cis rs7666738 0.747 rs2865955 chr4:99040518 A/C cg17366294 chr4:99064904 C4orf37 0.44 7.5 0.38 6.02e-13 Colonoscopy-negative controls vs population controls; CRC cis rs7107770 0.739 rs12788937 chr11:125082221 G/A cg27629782 chr11:125073726 PKNOX2 0.53 7.75 0.39 1.16e-13 Photic sneeze reflex; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg25187254 chr7:100797533 AP1S1 0.4 6.56 0.34 2.13e-10 Liver disease severity in Alagille syndrome; CRC cis rs13064411 0.696 rs7631082 chr3:113208913 C/G cg10517650 chr3:113235015 CCDC52 -0.41 -7.18 -0.37 4.55e-12 Response to simvastatin treatment (PCSK9 protein level change); CRC cis rs58688157 0.705 rs7122021 chr11:595810 A/G cg16486109 chr11:613632 IRF7 0.74 12.49 0.57 1.41e-29 Systemic lupus erythematosus; CRC cis rs8072100 0.840 rs9912311 chr17:45547132 T/C cg25173405 chr17:45401733 C17orf57 -0.48 -7.57 -0.39 3.71e-13 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs853679 0.517 rs1947862 chr6:28105196 C/T cg03623178 chr6:28175578 NA 0.96 12.59 0.57 6.03e-30 Depression; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg08438989 chr1:181999219 NA 0.45 6.18 0.32 1.85e-9 Anxiety disorder; CRC cis rs1003719 0.680 rs7276569 chr21:38578207 C/T cg10648535 chr21:38446584 PIGP;TTC3 -0.45 -6.23 -0.32 1.41e-9 Eye color traits; CRC cis rs929354 0.742 rs7806775 chr7:156947199 A/G cg17757837 chr7:157058334 UBE3C 0.74 12.39 0.56 3.31e-29 Body mass index; CRC cis rs4713118 0.587 rs61471148 chr6:28037032 T/A cg21251018 chr6:28226885 NKAPL 0.46 6.16 0.32 2.12e-9 Parkinson's disease; CRC trans rs3960554 0.867 rs79359354 chr7:75702597 G/A cg19862616 chr7:65841803 NCRNA00174 0.65 7.87 0.4 5.01e-14 Eotaxin levels; CRC trans rs61931739 0.534 rs11053000 chr12:34079022 C/T cg26384229 chr12:38710491 ALG10B 0.54 6.96 0.36 1.91e-11 Morning vs. evening chronotype; CRC trans rs2303319 0.504 rs56371522 chr2:162491109 G/A cg16721101 chr20:25176146 ENTPD6 -0.7 -6.09 -0.32 3.23e-9 Cognitive function; CRC cis rs7727544 0.716 rs10058655 chr5:131570896 A/T cg22638593 chr5:131593259 PDLIM4 0.35 6.43 0.33 4.55e-10 Blood metabolite levels; CRC cis rs9325144 0.560 rs11182979 chr12:38642562 C/A cg26384229 chr12:38710491 ALG10B -0.55 -8.15 -0.41 7.53e-15 Morning vs. evening chronotype; CRC cis rs11212617 0.901 rs11212538 chr11:108045956 C/T cg01991180 chr11:108092276 ATM;NPAT 0.4 5.75 0.3 2e-8 Response to metformin in type 2 diabetes (glycemic); CRC cis rs6952808 0.531 rs3800922 chr7:2184505 A/G cg04267008 chr7:1944627 MAD1L1 -0.62 -8.27 -0.42 3.25e-15 Bipolar disorder and schizophrenia; CRC cis rs7959452 0.535 rs7133487 chr12:69774377 G/A cg20891283 chr12:69753455 YEATS4 0.91 17.14 0.69 1.69e-47 Blood protein levels; CRC cis rs7552404 0.691 rs61770550 chr1:76366966 C/T cg22875332 chr1:76189707 ACADM 0.64 7.83 0.4 6.7e-14 Blood metabolite levels;Acylcarnitine levels; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg12311644 chr22:31687046 PIK3IP1 0.5 7.33 0.37 1.75e-12 Response to antipsychotic treatment; CRC trans rs6703335 0.870 rs10803142 chr1:243598234 A/G cg06635371 chr11:62554837 TMEM179B 0.45 6.26 0.33 1.23e-9 Schizophrenia;Schizophrenia, schizoaffective disorder or bipolar disorder; CRC trans rs2413994 0.666 rs7173644 chr15:50232552 C/T cg07095997 chr14:61188431 SIX4 0.36 6.26 0.33 1.19e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs6570726 0.791 rs1935612 chr6:145906090 T/A cg13319975 chr6:146136371 FBXO30 -0.41 -6.02 -0.32 4.64e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs796364 0.806 rs1509832 chr2:200874443 G/T cg25936922 chr2:200820526 C2orf60;C2orf47 0.68 6.64 0.34 1.33e-10 Schizophrenia; CRC cis rs2075371 1.000 rs2544218 chr7:133992315 C/A cg02659138 chr7:134003124 SLC35B4 0.37 6.41 0.33 5.12e-10 Mean platelet volume; CRC cis rs7772486 0.558 rs9376965 chr6:146130055 G/A cg23711669 chr6:146136114 FBXO30 0.66 9.78 0.47 5.25e-20 Lobe attachment (rater-scored or self-reported); CRC cis rs1218582 0.710 rs4845687 chr1:154878911 A/G cg03351412 chr1:154909251 PMVK 0.54 8.68 0.43 1.92e-16 Prostate cancer; CRC cis rs2236521 0.714 rs6062210 chr20:60890375 A/G cg09594475 chr20:60884601 LAMA5 0.35 5.95 0.31 6.99e-9 Pelvic organ prolapse; CRC cis rs877282 0.945 rs71491311 chr10:791747 G/A cg17470449 chr10:769945 NA 0.68 9.03 0.45 1.48e-17 Uric acid levels; CRC cis rs10883723 0.810 rs2296582 chr10:104244139 G/T cg11453585 chr10:104263688 ACTR1A;SUFU 0.87 15.12 0.64 1.37e-39 Allergic disease (asthma, hay fever or eczema); CRC cis rs10504229 0.683 rs10504224 chr8:58143735 A/G cg21724239 chr8:58056113 NA 0.74 9.33 0.46 1.62e-18 Developmental language disorder (linguistic errors); CRC cis rs6968419 0.674 rs4730726 chr7:115913336 T/A cg02561103 chr7:115862891 TES -0.42 -6.32 -0.33 8.42e-10 Intraocular pressure; CRC cis rs225245 0.817 rs225284 chr17:33933006 A/C cg05299278 chr17:33885742 SLFN14 0.47 7.69 0.39 1.71e-13 Reticulocyte count;Reticulocyte fraction of red cells;High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells; CRC cis rs372883 0.648 rs2832296 chr21:30741454 C/T cg24692254 chr21:30365293 RNF160 -0.59 -8.82 -0.44 7e-17 Pancreatic cancer; CRC cis rs796364 0.951 rs281793 chr2:200847990 G/A cg23649088 chr2:200775458 C2orf69 0.54 5.8 0.3 1.58e-8 Schizophrenia; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg07508260 chr11:111742291 ALG9 0.49 6.88 0.35 2.99e-11 Response to antipsychotic treatment; CRC cis rs155076 1.000 rs658244 chr13:21850976 T/C cg21970626 chr13:21893289 NA 0.47 6.2 0.32 1.67e-9 White matter hyperintensity burden; CRC cis rs6500602 0.564 rs3747584 chr16:4516092 A/G cg06139259 chr16:4526053 HMOX2;NMRAL1 0.52 6.77 0.35 6.01e-11 Schizophrenia; CRC cis rs951366 0.966 rs11240565 chr1:205722958 C/T cg17178900 chr1:205818956 PM20D1 -0.4 -5.7 -0.3 2.73e-8 Menarche (age at onset); CRC trans rs9341835 0.740 rs4710255 chr6:64156268 A/C cg13657004 chr13:50234944 EBPL -0.37 -6.18 -0.32 1.89e-9 Schizophrenia; CRC cis rs8180040 0.932 rs11712445 chr3:47434552 T/C cg10298567 chr3:47292165 KIF9 -0.35 -5.83 -0.31 1.33e-8 Colorectal cancer; CRC cis rs7632954 0.567 rs6793940 chr3:8535006 C/A cg03495237 chr3:8533978 NA 0.35 6.31 0.33 9.23e-10 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs6860806 0.507 rs272878 chr5:131671769 C/T cg12564285 chr5:131593104 PDLIM4 -0.47 -8.14 -0.41 8.26e-15 Breast cancer; CRC cis rs1218582 0.741 rs4339857 chr1:154888962 A/G cg16680214 chr1:154839983 KCNN3 -0.46 -9.08 -0.45 1.01e-17 Prostate cancer; CRC cis rs8177253 0.665 rs12493887 chr3:133440737 T/C cg11941060 chr3:133502564 NA -0.44 -7.25 -0.37 3.09e-12 Iron status biomarkers; CRC cis rs6502050 0.835 rs7219180 chr17:80079968 C/G cg09264619 chr17:80180166 NA 0.37 6.13 0.32 2.47e-9 Life satisfaction; CRC cis rs736408 0.609 rs2230535 chr3:52800284 T/C cg05573699 chr3:52720067 GNL3;PBRM1 -0.46 -6.47 -0.34 3.61e-10 Bipolar disorder; CRC trans rs4942242 0.640 rs17460861 chr13:44230078 C/G cg26741380 chr15:41871084 TYRO3 0.49 6.89 0.36 2.9e-11 Response to tocilizumab in rheumatoid arthritis; CRC cis rs4901869 0.966 rs12893803 chr14:59329655 T/C cg02291164 chr14:59296302 NA 0.37 6.77 0.35 5.84e-11 Panic disorder; CRC cis rs11676348 0.935 rs6716276 chr2:218962205 A/G cg00012203 chr2:219082015 ARPC2 -0.38 -5.8 -0.3 1.52e-8 Ulcerative colitis; CRC cis rs10751667 0.643 rs7394436 chr11:970373 G/C cg06064525 chr11:970664 AP2A2 -0.3 -6.11 -0.32 2.78e-9 Alzheimer's disease (late onset); CRC cis rs449789 0.857 rs1875816 chr6:159720314 A/G cg14500486 chr6:159655392 FNDC1 -0.48 -7.39 -0.38 1.24e-12 Pulse pressure; CRC cis rs6500395 0.962 rs1115759 chr16:48599530 A/G cg04672837 chr16:48644449 N4BP1 0.41 5.92 0.31 8.31e-9 Response to tocilizumab in rheumatoid arthritis; CRC cis rs7772486 0.686 rs4896833 chr6:145965673 T/G cg23711669 chr6:146136114 FBXO30 0.67 11.09 0.52 1.73e-24 Lobe attachment (rater-scored or self-reported); CRC trans rs116095464 0.558 rs10036253 chr5:238519 A/C cg00938859 chr5:1591904 SDHAP3 0.74 7.92 0.4 3.68e-14 Breast cancer; CRC cis rs7208859 0.623 rs8067035 chr17:29102188 T/C cg13385521 chr17:29058706 SUZ12P 0.7 8.15 0.41 7.6e-15 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg08870933 chr16:71879943 ATXN1L 0.4 6.47 0.34 3.49e-10 Liver disease severity in Alagille syndrome; CRC cis rs736408 0.540 rs4687637 chr3:52634092 C/T cg11645453 chr3:52864694 ITIH4 0.32 5.72 0.3 2.44e-8 Bipolar disorder; CRC cis rs45509595 0.841 rs200485 chr6:27775697 G/C cg15845792 chr6:28175446 NA 0.75 6.47 0.34 3.6e-10 Breast cancer; CRC trans rs2727020 0.558 rs1164675 chr11:49325972 C/T cg11707556 chr5:10655725 ANKRD33B 0.38 6.61 0.34 1.57e-10 Coronary artery disease; CRC cis rs453301 0.686 rs11785819 chr8:8870378 T/G cg14979609 chr8:8086686 FLJ10661 0.38 6.08 0.32 3.42e-9 Joint mobility (Beighton score); CRC cis rs13108904 0.905 rs11247983 chr4:1281951 C/G cg16405210 chr4:1374714 KIAA1530 -0.44 -6.04 -0.32 4.14e-9 Obesity-related traits; CRC cis rs477692 0.685 rs3852507 chr10:131399616 G/T cg05714579 chr10:131428358 MGMT -0.55 -7.61 -0.39 2.83e-13 Response to temozolomide; CRC cis rs4713118 0.516 rs4713142 chr6:28106347 T/G cg23161317 chr6:28129485 ZNF389 0.53 6.54 0.34 2.37e-10 Parkinson's disease; CRC cis rs7617773 0.746 rs11713476 chr3:48375434 C/T cg11946769 chr3:48343235 NME6 0.65 9.07 0.45 1.09e-17 Coronary artery disease; CRC cis rs9649213 0.593 rs12704983 chr7:97927045 G/A cg24562669 chr7:97807699 LMTK2 0.43 7.24 0.37 3.19e-12 Prostate cancer (SNP x SNP interaction); CRC cis rs6831352 0.918 rs29001231 chr4:100046680 T/C cg12011299 chr4:100065546 ADH4 -0.49 -9.27 -0.45 2.61e-18 Alcohol dependence; CRC cis rs7208859 0.623 rs216445 chr17:28933576 A/G cg19761014 chr17:28927070 LRRC37B2 0.56 5.68 0.3 2.94e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs9549367 0.577 rs3024713 chr13:113813321 G/A cg00898013 chr13:113819073 PROZ -0.49 -6.42 -0.33 4.85e-10 Platelet distribution width; CRC cis rs904251 0.861 rs1757171 chr6:37487044 T/C cg01843034 chr6:37503916 NA -0.48 -9.06 -0.45 1.18e-17 Cognitive performance; CRC cis rs56399783 0.901 rs17132594 chr7:2775102 G/A cg19731401 chr7:2775893 GNA12 0.66 7.04 0.36 1.16e-11 Childhood ear infection; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg01622965 chr7:98476371 TRRAP 0.44 6.11 0.32 2.76e-9 Response to antipsychotic treatment; CRC cis rs11785400 1.000 rs6997670 chr8:143737915 G/A cg10596483 chr8:143751796 JRK 0.49 6.85 0.35 3.71e-11 Schizophrenia; CRC cis rs2303759 0.918 rs10405465 chr19:49869298 C/T cg22307029 chr19:49891270 CCDC155 0.62 9.01 0.44 1.68e-17 Multiple sclerosis; CRC cis rs11098499 0.562 rs13101722 chr4:120555975 C/A cg09307838 chr4:120376055 NA -0.58 -8.9 -0.44 3.72e-17 Corneal astigmatism; CRC cis rs853679 0.517 rs35512245 chr6:28079953 T/C cg23161317 chr6:28129485 ZNF389 0.54 6.56 0.34 2.06e-10 Depression; CRC cis rs2242116 0.592 rs6442039 chr3:46960797 C/G cg02527881 chr3:46936655 PTH1R -0.45 -6.82 -0.35 4.39e-11 Birth weight; CRC cis rs7666738 0.830 rs13140676 chr4:98804978 C/T cg05340658 chr4:99064831 C4orf37 0.55 8.16 0.41 7.26e-15 Colonoscopy-negative controls vs population controls; CRC cis rs9323205 0.765 rs2999389 chr14:51654510 G/A cg23942311 chr14:51606299 NA 0.62 9.88 0.48 2.46e-20 Cancer; CRC cis rs12477438 0.559 rs6733285 chr2:99725575 T/C cg26064155 chr2:99771622 LIPT1;TSGA10 0.77 13.1 0.59 7.65e-32 Chronic sinus infection; CRC trans rs875971 0.660 rs2191268 chr7:66110224 C/T cg23812325 chr4:56915719 NA -0.41 -6.31 -0.33 9.22e-10 Aortic root size; CRC cis rs6951245 1.000 rs11770909 chr7:1086716 G/A cg08132940 chr7:1081526 C7orf50 -0.55 -5.64 -0.3 3.64e-8 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs4481887 0.893 rs6587450 chr1:248480496 T/A cg00666640 chr1:248458726 OR2T12 0.48 8.09 0.41 1.12e-14 Common traits (Other); CRC cis rs4237845 0.611 rs4760347 chr12:58346868 T/C cg02175503 chr12:58329896 NA 0.76 11.97 0.55 1.2100000000000001e-27 Intelligence (multi-trait analysis); CRC trans rs853679 0.760 rs9368563 chr6:28208558 A/G cg06606381 chr12:133084897 FBRSL1 -0.65 -6.7 -0.35 8.99e-11 Depression; CRC trans rs79976124 0.837 rs10944858 chr6:66646039 G/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.76 9.55 0.47 3.03e-19 Type 2 diabetes; CRC cis rs1555322 0.530 rs2297789 chr20:33867248 A/T cg13662093 chr20:33865505 NA 0.45 6.25 0.33 1.24e-9 Attention deficit hyperactivity disorder; CRC cis rs67478160 0.643 rs2223937 chr14:104286380 A/G cg01849466 chr14:104193079 ZFYVE21 -0.47 -8.31 -0.42 2.53e-15 Schizophrenia; CRC cis rs7178572 0.568 rs4886515 chr15:77686886 G/A cg22256960 chr15:77711686 NA -0.66 -9.6 -0.47 2.13e-19 Type 2 diabetes; CRC cis rs1178968 0.901 rs9784947 chr7:72748888 C/G cg25889504 chr7:72793014 NA 0.53 6.04 0.32 4.16e-9 Triglyceride levels; CRC cis rs881375 0.631 rs10739577 chr9:123668854 C/T cg09586646 chr9:123605570 PSMD5;LOC253039 0.46 6.84 0.35 3.88e-11 Rheumatoid arthritis; CRC cis rs7172677 1.000 rs1021382 chr15:75417398 A/G cg14664628 chr15:75095509 CSK -0.49 -5.72 -0.3 2.34e-8 Systemic lupus erythematosus and Systemic sclerosis; CRC cis rs2227564 0.729 rs2688615 chr10:75651499 C/G cg00564723 chr10:75632066 CAMK2G -0.33 -7.63 -0.39 2.58e-13 Crohn's disease;Inflammatory bowel disease; CRC trans rs7615952 0.866 rs1976459 chr3:125647486 A/T cg07211511 chr3:129823064 LOC729375 -1.07 -18.03 -0.7 4.94e-51 Blood pressure (smoking interaction); CRC cis rs1797081 1.000 rs780634 chr10:16864327 T/G cg23933602 chr10:16859644 RSU1 1.08 21.47 0.76 1.48e-64 Platelet distribution width; CRC cis rs1552244 0.816 rs13076197 chr3:10019773 T/C cg00166722 chr3:10149974 C3orf24 0.61 7.92 0.4 3.81e-14 Alzheimer's disease; CRC cis rs4713118 0.513 rs149897 chr6:28006650 A/G cg02683197 chr6:28174875 NA 0.61 8.54 0.43 5.01e-16 Parkinson's disease; CRC cis rs2070488 1.000 rs1002675 chr3:38445226 C/T cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.83 15.07 0.64 2.12e-39 Electrocardiographic conduction measures; CRC cis rs644799 0.526 rs530914 chr11:95632156 C/T cg03916912 chr11:95522834 CEP57;FAM76B 0.66 10.61 0.5 8.4e-23 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs3617 0.532 rs9836499 chr3:52904524 G/T cg11645453 chr3:52864694 ITIH4 -0.37 -7.03 -0.36 1.24e-11 Red blood cell count;Autism spectrum disorder or schizophrenia; CRC trans rs11098499 0.691 rs2136911 chr4:120265859 G/A cg25214090 chr10:38739885 LOC399744 0.53 8.51 0.42 6.36e-16 Corneal astigmatism; CRC cis rs6735179 0.837 rs6745451 chr2:1776761 C/T cg19300414 chr2:1746591 PXDN 0.38 5.81 0.31 1.44e-8 Response to antipsychotic treatment; CRC cis rs7824557 0.583 rs2263511 chr8:11233318 A/C cg08071915 chr8:12219732 FAM66A 0.36 6.38 0.33 5.96e-10 Retinal vascular caliber; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg05148093 chr5:140027274 NDUFA2;IK 0.48 6.16 0.32 2.11e-9 Thyroid stimulating hormone; CRC cis rs6500602 0.626 rs7665 chr16:4562512 A/G cg13763550 chr16:4524223 NMRAL1;HMOX2 0.45 5.62 0.3 4.12e-8 Schizophrenia; CRC cis rs7312933 0.558 rs11181507 chr12:42844763 T/A cg19980929 chr12:42632907 YAF2 0.4 5.96 0.31 6.49e-9 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CRC cis rs11122272 0.735 rs2474634 chr1:231487017 T/C cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.5 -7.6 -0.39 3.18e-13 Hemoglobin concentration; CRC cis rs7618915 0.547 rs2118540 chr3:52629386 T/C cg07507251 chr3:52567010 NT5DC2 0.45 6.51 0.34 2.8e-10 Bipolar disorder; CRC cis rs4466137 0.553 rs16898 chr5:82986149 T/C cg16102102 chr5:83017553 HAPLN1 -0.47 -7.97 -0.4 2.65e-14 Prostate cancer; CRC cis rs861020 0.630 rs655712 chr1:210006437 G/A cg09163369 chr1:210001066 C1orf107 0.4 5.75 0.3 2.08e-8 Orofacial clefts; CRC cis rs4917300 0.605 rs10108708 chr8:143102886 A/G cg25363559 chr8:143086065 NA -0.33 -6.35 -0.33 7.25e-10 Amyotrophic lateral sclerosis; CRC cis rs4253772 0.591 rs6008546 chr22:46686377 T/G cg24881330 chr22:46731750 TRMU 0.63 7.48 0.38 6.63e-13 LDL cholesterol;Cholesterol, total; CRC cis rs10751667 0.600 rs7394783 chr11:1005108 C/T cg23136738 chr11:925521 AP2A2 0.4 6.23 0.32 1.42e-9 Alzheimer's disease (late onset); CRC cis rs8180040 1.000 rs295458 chr3:47385585 C/A cg02527881 chr3:46936655 PTH1R -0.4 -7.66 -0.39 2.09e-13 Colorectal cancer; CRC cis rs4363385 0.693 rs402153 chr1:153054212 A/G cg25856811 chr1:152973957 SPRR3 -0.24 -6.45 -0.34 3.95e-10 Inflammatory skin disease; CRC cis rs7833790 0.927 rs61020899 chr8:82757090 C/T cg17211192 chr8:82754475 SNX16 0.54 6.74 0.35 7.23e-11 Diastolic blood pressure; CRC cis rs7945705 1.000 rs7937298 chr11:8867509 G/C cg14711859 chr11:8959438 ASCL3 -0.49 -7.84 -0.4 6.46e-14 Hemoglobin concentration; CRC cis rs10504229 0.639 rs56066782 chr8:58105857 A/G cg02725872 chr8:58115012 NA -0.66 -11.36 -0.53 1.85e-25 Developmental language disorder (linguistic errors); CRC cis rs11674184 0.659 rs11679605 chr2:11722468 G/A cg07314298 chr2:11723111 GREB1 -0.54 -8.68 -0.43 1.86e-16 Endometriosis; CRC cis rs10504229 1.000 rs17805326 chr8:58169533 A/C cg02725872 chr8:58115012 NA -0.39 -6.5 -0.34 3.01e-10 Developmental language disorder (linguistic errors); CRC cis rs1538970 0.962 rs3219472 chr1:45804050 A/G cg05343316 chr1:45956843 TESK2 -0.64 -8.52 -0.43 5.66e-16 Platelet count; CRC cis rs2857891 1.000 rs2638092 chr11:6961746 G/A cg26870460 chr11:6947759 ZNF215 0.56 5.88 0.31 1.03e-8 Response to cytadine analogues (cytosine arabinoside); CRC cis rs9858542 0.953 rs34363169 chr3:49537712 G/A cg07274523 chr3:49395745 GPX1 0.47 6.4 0.33 5.33e-10 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs6570726 0.791 rs407887 chr6:145843759 C/T cg05347473 chr6:146136440 FBXO30 0.4 6.24 0.33 1.37e-9 Lobe attachment (rater-scored or self-reported); CRC trans rs35110281 0.811 rs9980185 chr21:45057905 A/G cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.49 8.28 0.42 3.06e-15 Mean corpuscular volume; CRC cis rs7726839 0.574 rs72705017 chr5:623733 G/A cg09021430 chr5:549028 NA -0.73 -8.37 -0.42 1.66e-15 Obesity-related traits; CRC cis rs977987 0.843 rs62062564 chr16:75442622 G/A cg03315344 chr16:75512273 CHST6 0.53 8.84 0.44 5.77e-17 Dupuytren's disease; CRC cis rs4423214 0.879 rs1790330 chr11:71147825 C/T cg05163923 chr11:71159392 DHCR7 -0.64 -7.87 -0.4 5.08e-14 Vitamin D levels; CRC cis rs9463078 0.764 rs9367208 chr6:44830180 G/A cg25276700 chr6:44698697 NA -0.28 -6.73 -0.35 7.45e-11 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; CRC trans rs10411161 0.702 rs8100716 chr19:52384061 T/C cg22319618 chr22:45562946 NUP50 -0.69 -7.66 -0.39 2.09e-13 Breast cancer; CRC cis rs1506636 1.000 rs1911145 chr7:123363658 A/G cg03229431 chr7:123269106 ASB15 -0.74 -11.75 -0.54 7.63e-27 Plateletcrit;Platelet count; CRC cis rs4253772 0.591 rs6519994 chr22:46656805 A/G cg09491104 chr22:46646882 C22orf40 0.47 7.38 0.38 1.32e-12 LDL cholesterol;Cholesterol, total; CRC cis rs10782582 0.593 rs74968421 chr1:76233496 T/C cg10523679 chr1:76189770 ACADM -0.44 -6.31 -0.33 8.77e-10 Daytime sleep phenotypes; CRC cis rs7762018 1.000 rs73242910 chr6:170114670 A/G cg19338460 chr6:170058176 WDR27 -0.73 -7.88 -0.4 4.76e-14 Thiazide-induced adverse metabolic effects in hypertensive patients; CRC trans rs1814175 0.645 rs11040661 chr11:49952146 G/T cg03929089 chr4:120376271 NA -0.9 -15.65 -0.65 1.22e-41 Height; CRC cis rs9549367 0.713 rs3024764 chr13:113824314 A/G cg00898013 chr13:113819073 PROZ -0.54 -7.92 -0.4 3.81e-14 Platelet distribution width; CRC cis rs7605827 0.893 rs35123590 chr2:15708639 T/C cg19274914 chr2:15703543 NA 0.37 5.76 0.3 1.96e-8 Educational attainment (years of education); CRC cis rs9309711 0.736 rs28619526 chr2:3496804 T/C cg10845886 chr2:3471009 TTC15 -0.58 -8.62 -0.43 2.95e-16 Neurofibrillary tangles; CRC cis rs9527 0.615 rs7917295 chr10:104701187 A/G cg15744005 chr10:104629667 AS3MT -0.31 -6.31 -0.33 9.25e-10 Arsenic metabolism; CRC cis rs11628318 0.853 rs6575925 chr14:103034507 C/T cg02094049 chr14:103021097 NA -0.55 -7.22 -0.37 3.63e-12 Platelet count; CRC cis rs4073582 0.595 rs474005 chr11:66033301 C/T cg16950941 chr11:66035639 RAB1B 0.71 12.12 0.56 3.47e-28 Gout; CRC cis rs17601876 0.814 rs8042086 chr15:51561478 C/T cg19946085 chr15:51559439 CYP19A1 -0.34 -6.99 -0.36 1.57e-11 Estrone/androstenedione ratio in resected early stage-receptor positive breast cancer; CRC trans rs7937682 0.961 rs11601674 chr11:111634354 C/T cg18187862 chr3:45730750 SACM1L 0.53 7.59 0.39 3.39e-13 Primary sclerosing cholangitis; CRC cis rs6426558 0.515 rs7412928 chr1:227332148 C/T cg10327440 chr1:227177885 CDC42BPA -0.46 -6.9 -0.36 2.63e-11 Neutrophil percentage of white cells; CRC cis rs2842992 0.872 rs2758330 chr6:160104844 G/T cg11366901 chr6:160182831 ACAT2 0.88 11.77 0.54 6.18e-27 Age-related macular degeneration (geographic atrophy); CRC cis rs875971 0.571 rs78668714 chr7:65939451 G/A cg18876405 chr7:65276391 NA 0.46 6.31 0.33 9.12e-10 Aortic root size; CRC cis rs514406 0.929 rs483073 chr1:53314084 T/C cg24675658 chr1:53192096 ZYG11B -0.54 -7.97 -0.4 2.7e-14 Monocyte count; CRC cis rs875971 0.965 rs6971509 chr7:65714970 G/T cg00343986 chr7:65444356 GUSB -0.45 -6.49 -0.34 3.16e-10 Aortic root size; CRC cis rs847577 0.748 rs940432 chr7:97716483 G/A cg00277769 chr7:97922759 BAIAP2L1 -0.4 -6.78 -0.35 5.43e-11 Breast cancer; CRC cis rs910316 0.737 rs175080 chr14:75513828 G/A cg11812906 chr14:75593930 NEK9 -0.58 -9.04 -0.45 1.38e-17 Height; CRC cis rs9303401 0.659 rs35103007 chr17:56900738 G/A cg10487724 chr17:56770010 TEX14;RAD51C 0.76 9.49 0.46 4.69e-19 Cognitive test performance; CRC cis rs1023500 0.505 rs134886 chr22:42673856 C/T cg04733989 chr22:42467013 NAGA -0.43 -6.29 -0.33 1.01e-9 Schizophrenia; CRC cis rs951366 0.617 rs9438393 chr1:205782718 A/G cg14159672 chr1:205819179 PM20D1 0.91 14.92 0.64 8.42e-39 Menarche (age at onset); CRC cis rs875971 0.830 rs427973 chr7:65526648 C/A cg18912574 chr7:65842487 NCRNA00174 0.39 6.7 0.35 9.14e-11 Aortic root size; CRC cis rs17092148 1.000 rs6060043 chr20:33364584 C/T cg08999081 chr20:33150536 PIGU 0.46 5.68 0.3 3.01e-8 Neuroticism; CRC cis rs11997175 0.509 rs67427312 chr8:33674377 A/G cg04338863 chr8:33670619 NA 0.47 6.89 0.36 2.85e-11 Body mass index; CRC cis rs919433 0.510 rs34631382 chr2:198390009 C/T cg10820045 chr2:198174542 NA 0.41 6.91 0.36 2.5e-11 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC cis rs10504229 0.728 rs17804822 chr8:58156276 T/C cg21724239 chr8:58056113 NA 0.64 8.47 0.42 8.16e-16 Developmental language disorder (linguistic errors); CRC cis rs9372498 0.536 rs62422189 chr6:118907053 C/T cg01339444 chr6:118972232 C6orf204 0.58 6.44 0.33 4.28e-10 Diastolic blood pressure; CRC cis rs734999 0.588 rs2764848 chr1:2530694 G/A cg18854424 chr1:2615690 NA -0.41 -7.78 -0.39 9.14e-14 Ulcerative colitis; CRC cis rs28386778 0.897 rs11654841 chr17:61838259 C/T cg11494091 chr17:61959527 GH2 0.59 10.13 0.49 3.61e-21 Prudent dietary pattern; CRC trans rs4942242 0.512 rs9533551 chr13:44187120 G/C cg26741380 chr15:41871084 TYRO3 -0.52 -7.14 -0.37 6.1e-12 Response to tocilizumab in rheumatoid arthritis; CRC cis rs6867032 0.874 rs4975786 chr5:2004724 T/C cg26168224 chr5:2018326 NA -0.86 -13.19 -0.59 3.58e-32 Gut microbiome composition (winter); CRC cis rs780096 0.546 rs12473776 chr2:27636474 A/G cg12000995 chr2:27665139 KRTCAP3 -0.31 -6.48 -0.34 3.31e-10 Total body bone mineral density; CRC cis rs853679 0.517 rs9368555 chr6:28108967 T/C cg18032046 chr6:28092343 ZSCAN16 -0.51 -5.93 -0.31 7.47e-9 Depression; CRC cis rs6840360 0.615 rs1561916 chr4:152479234 C/T cg09659197 chr4:152720779 NA 0.31 5.64 0.3 3.6e-8 Intelligence (multi-trait analysis); CRC cis rs9611565 0.729 rs4822027 chr22:41786227 G/A cg06481639 chr22:41940642 POLR3H -0.51 -5.73 -0.3 2.22e-8 Vitiligo; CRC cis rs881375 0.933 rs2239657 chr9:123671520 A/G cg09586646 chr9:123605570 PSMD5;LOC253039 -0.49 -6.68 -0.35 1.05e-10 Rheumatoid arthritis; CRC cis rs6570726 0.967 rs9497316 chr6:145792387 G/T cg05347473 chr6:146136440 FBXO30 -0.37 -5.79 -0.3 1.65e-8 Lobe attachment (rater-scored or self-reported); CRC cis rs6860806 0.507 rs272892 chr5:131664349 C/T cg02033258 chr5:131593261 PDLIM4 0.38 6.37 0.33 6.44e-10 Breast cancer; CRC cis rs4073582 0.595 rs555360 chr11:65960061 T/C cg14036092 chr11:66035641 RAB1B -0.51 -8.25 -0.41 3.98e-15 Gout; CRC cis rs1656402 1.000 rs1656398 chr2:233427852 C/T cg03852847 chr2:233439513 NA -0.45 -7.69 -0.39 1.76e-13 Non-small cell lung cancer (survival); CRC cis rs3812762 0.783 rs34524863 chr11:8777408 T/C cg00186954 chr11:8933980 ST5;C11orf17 -0.41 -6.59 -0.34 1.8e-10 Hypospadias; CRC cis rs7072216 0.763 rs942804 chr10:100168499 C/A cg26618903 chr10:100175079 PYROXD2 -0.55 -9.25 -0.45 2.92e-18 Metabolite levels; CRC cis rs8031584 0.679 rs34017474 chr15:31230611 T/C cg14829155 chr15:31115871 NA -0.42 -7.14 -0.37 5.96e-12 Huntington's disease progression; CRC cis rs12476592 0.602 rs2305157 chr2:63822785 T/C cg10828910 chr2:63850056 LOC388955 0.48 5.86 0.31 1.15e-8 Childhood ear infection; CRC cis rs883565 0.682 rs7623850 chr3:39053311 C/T cg01426195 chr3:39028469 NA -0.53 -8.56 -0.43 4.39e-16 Handedness; CRC cis rs9291683 0.588 rs13133766 chr4:10019732 C/T cg11266682 chr4:10021025 SLC2A9 0.54 11.57 0.54 3.2e-26 Bone mineral density; CRC cis rs7412746 0.611 rs11204748 chr1:150927369 G/T cg15448220 chr1:150897856 SETDB1 0.46 6.84 0.35 3.98e-11 Melanoma; CRC cis rs78456975 1.000 rs72776251 chr2:1525097 G/A cg12573674 chr2:1569213 NA -0.74 -7.3 -0.37 2.21e-12 Placebo response in major depressive disorder (% change in symptom score); CRC cis rs6912958 0.781 rs9450739 chr6:88268271 G/A cg12350822 chr6:88032061 C6orf162;GJB7 -0.33 -6.36 -0.33 6.84e-10 Monocyte percentage of white cells; CRC cis rs2404602 0.647 rs11072619 chr15:77043242 A/C cg03037974 chr15:76606532 NA -0.57 -8.7 -0.43 1.64e-16 Blood metabolite levels; CRC cis rs6500395 1.000 rs11647048 chr16:48623227 T/G cg04672837 chr16:48644449 N4BP1 0.42 6.04 0.32 4.1e-9 Response to tocilizumab in rheumatoid arthritis; CRC trans rs1814175 0.592 rs1794161 chr11:49898825 A/C cg03929089 chr4:120376271 NA -0.91 -16.03 -0.66 3.68e-43 Height; CRC trans rs4130344 0.935 rs11725623 chr4:159732671 A/G cg04008429 chr3:160167646 TRIM59 -0.43 -6.31 -0.33 8.77e-10 Intelligence (multi-trait analysis); CRC cis rs9372498 0.536 rs62422236 chr6:118972633 G/T cg01339444 chr6:118972232 C6orf204 0.58 6.25 0.33 1.25e-9 Diastolic blood pressure; CRC cis rs12612619 0.732 rs13021112 chr2:27259794 G/A cg00617064 chr2:27272375 NA -0.4 -6.57 -0.34 2.01e-10 Venous thromboembolism adjusted for sickle cell variant rs77121243-T; CRC cis rs10504229 0.683 rs72649187 chr8:58108320 A/G cg05313129 chr8:58192883 C8orf71 -0.43 -5.83 -0.31 1.36e-8 Developmental language disorder (linguistic errors); CRC cis rs7264396 0.887 rs6120951 chr20:34045191 G/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.39 -6.41 -0.33 5.12e-10 Total cholesterol levels; CRC cis rs10504229 0.906 rs7842482 chr8:58167720 A/T cg02290350 chr8:58132656 NA -0.44 -7.03 -0.36 1.23e-11 Developmental language disorder (linguistic errors); CRC cis rs7617773 0.780 rs11130164 chr3:48369034 G/A cg11946769 chr3:48343235 NME6 0.72 9.58 0.47 2.48e-19 Coronary artery disease; CRC cis rs10540 0.841 rs35601764 chr11:532923 A/C cg03352830 chr11:487213 PTDSS2 0.65 7.33 0.37 1.75e-12 Body mass index; CRC trans rs2055729 1.000 rs2055729 chr8:9792662 C/T cg06636001 chr8:8085503 FLJ10661 -0.45 -6.45 -0.34 4.05e-10 Multiple myeloma (hyperdiploidy); CRC cis rs4819052 0.724 rs9753962 chr21:46661384 G/T cg02159808 chr21:46707872 POFUT2;LOC642852 0.49 6.41 0.33 5.19e-10 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs2734839 0.964 rs1116313 chr11:113296107 A/G cg14159747 chr11:113255604 NA 0.46 7.95 0.4 2.96e-14 Information processing speed; CRC cis rs881375 0.933 rs1548784 chr9:123685280 T/C cg14255062 chr9:123606675 PSMD5;LOC253039 0.4 5.83 0.31 1.35e-8 Rheumatoid arthritis; CRC cis rs3820068 0.603 rs6696286 chr1:15968770 C/T cg17385448 chr1:15911702 AGMAT 0.28 5.61 0.3 4.22e-8 Systolic blood pressure; CRC cis rs10504229 0.683 rs2088217 chr8:58113124 C/T cg21724239 chr8:58056113 NA 0.5 6.89 0.35 2.89e-11 Developmental language disorder (linguistic errors); CRC cis rs17767392 0.681 rs1990035 chr14:71695958 G/T cg13720639 chr14:72061746 SIPA1L1 -0.54 -6.56 -0.34 2.15e-10 Mitral valve prolapse; CRC trans rs12599106 0.818 rs17723574 chr16:34602945 C/G cg01516881 chr6:292596 DUSP22 -0.56 -8.37 -0.42 1.69e-15 Menopause (age at onset); CRC cis rs16867321 0.853 rs73023563 chr2:181502830 C/T cg23363182 chr2:181467187 NA -0.51 -6.65 -0.34 1.21e-10 Obesity; CRC cis rs10782582 0.593 rs17585530 chr1:76134990 G/A cg03433033 chr1:76189801 ACADM -0.44 -6.18 -0.32 1.89e-9 Daytime sleep phenotypes; CRC cis rs3101457 0.530 rs10754827 chr1:244528390 A/G cg09033006 chr1:244517177 C1orf100 -0.41 -5.94 -0.31 7.16e-9 Smoking behavior; CRC cis rs9595066 1.000 rs9595066 chr13:44706268 C/T cg04068111 chr13:44716778 NA -0.4 -5.91 -0.31 8.56e-9 Schizophrenia; CRC cis rs10886558 0.674 rs10788015 chr10:121781396 C/T cg02041677 chr10:121771263 NA -0.32 -5.71 -0.3 2.59e-8 Shingles; CRC cis rs7274811 0.652 rs291694 chr20:32000351 A/G cg03904042 chr20:32255491 NECAB3;C20orf134 0.43 5.99 0.31 5.36e-9 Height; CRC cis rs11190604 1.000 rs11190572 chr10:102232879 A/G cg16342193 chr10:102329863 NA -0.36 -5.87 -0.31 1.07e-8 Palmitoleic acid (16:1n-7) levels; CRC cis rs992157 0.835 rs6729058 chr2:219148369 G/A cg04731861 chr2:219085781 ARPC2 0.34 6.97 0.36 1.74e-11 Colorectal cancer; CRC cis rs910316 1.000 rs12590452 chr14:75548756 T/C cg11812906 chr14:75593930 NEK9 0.64 10.38 0.5 5.13e-22 Height; CRC cis rs11750568 0.967 rs10464079 chr5:178525779 G/A cg10208897 chr5:178548229 ADAMTS2 0.35 5.69 0.3 2.81e-8 Height; CRC cis rs72781680 0.611 rs72783619 chr2:24311607 G/A cg20701182 chr2:24300061 SF3B14 0.63 7.55 0.38 4.44e-13 Lymphocyte counts; CRC cis rs174601 0.861 rs174547 chr11:61570783 C/T cg06781209 chr11:61594997 FADS2 0.38 5.72 0.3 2.42e-8 Blood metabolite levels;Red blood cell fatty acid levels;Liver enzyme levels (alkaline phosphatase);Gondoic acid (20:1n-9) levels;Trans fatty acid levels; CRC cis rs7572644 0.640 rs11891769 chr2:28025580 G/C cg27432699 chr2:27873401 GPN1 0.46 6.2 0.32 1.7e-9 Response to carboplatin and paclitaxel in ovarian cancer (Caspase 3/7 EC50); CRC cis rs6952808 0.689 rs12670737 chr7:2046830 C/T cg21782813 chr7:2030301 MAD1L1 0.53 9.37 0.46 1.17e-18 Bipolar disorder and schizophrenia; CRC cis rs9549328 0.611 rs72661939 chr13:113617498 C/T cg24588162 chr13:113633484 MCF2L 0.36 6.52 0.34 2.68e-10 Systolic blood pressure; CRC cis rs1881797 0.527 rs79724455 chr1:247646957 T/C cg18198730 chr1:247681584 NA 0.63 6.91 0.36 2.52e-11 Acute lymphoblastic leukemia (childhood); CRC cis rs7932354 0.554 rs6485721 chr11:47040854 A/G cg19486271 chr11:47235900 DDB2 -0.43 -6.34 -0.33 7.75e-10 Bone mineral density (hip);Bone mineral density; CRC cis rs72945132 0.882 rs17160753 chr11:70131462 A/G cg00319359 chr11:70116639 PPFIA1 0.61 6.79 0.35 5.14e-11 Coronary artery disease; CRC cis rs11098499 0.779 rs6815934 chr4:120267310 T/C cg24375607 chr4:120327624 NA 0.47 7.68 0.39 1.89e-13 Corneal astigmatism; CRC cis rs3760982 1.000 rs3760982 chr19:44286513 A/G cg11993925 chr19:44307056 LYPD5 0.47 7.75 0.39 1.15e-13 Breast cancer (estrogen-receptor negative);Breast cancer; CRC cis rs853679 0.517 rs17711801 chr6:28092307 C/G cg12273811 chr6:28175739 NA 0.73 9.36 0.46 1.34e-18 Depression; CRC cis rs7591163 0.959 rs10933217 chr2:228716226 T/C cg14646075 chr2:228736089 WDR69 -0.46 -6.2 -0.32 1.72e-9 Blood pressure; CRC cis rs2204008 0.522 rs12370263 chr12:38113311 A/G cg13010199 chr12:38710504 ALG10B 0.46 5.99 0.31 5.45e-9 Bladder cancer; CRC cis rs17711722 0.585 rs6942660 chr7:65302406 C/T cg18912574 chr7:65842487 NCRNA00174 0.33 5.68 0.3 2.9e-8 Calcium levels; CRC trans rs11039798 0.565 rs7118675 chr11:48532063 C/A cg15704280 chr7:45808275 SEPT13 0.63 6.5 0.34 3.01e-10 Axial length; CRC cis rs6541297 1.000 rs6681042 chr1:230278979 G/A cg05784532 chr1:230284198 GALNT2 0.45 6.28 0.33 1.1e-9 Coronary artery disease; CRC cis rs11792861 0.816 rs7027263 chr9:111699569 G/A cg05043794 chr9:111880884 C9orf5 -0.32 -5.75 -0.3 1.99e-8 Menarche (age at onset); CRC cis rs736408 0.509 rs3774349 chr3:52722335 A/C cg18404041 chr3:52824283 ITIH1 -0.3 -6.13 -0.32 2.58e-9 Bipolar disorder; CRC cis rs1728785 1.000 rs1728801 chr16:68571457 A/C cg02972257 chr16:68554789 NA -0.58 -7.15 -0.37 5.78e-12 Ulcerative colitis; CRC cis rs66573146 0.901 rs7668802 chr4:6986236 T/A cg00086871 chr4:6988644 TBC1D14 1.05 7.01 0.36 1.33e-11 Granulocyte percentage of myeloid white cells; CRC cis rs1153858 1.000 rs56806728 chr15:45637814 A/G cg21132104 chr15:45694354 SPATA5L1 0.58 8.6 0.43 3.24e-16 Homoarginine levels; CRC trans rs2228479 0.850 rs11640188 chr16:89807732 C/T cg24644049 chr4:85504048 CDS1 0.9 7.41 0.38 1.05e-12 Skin colour saturation; CRC cis rs3768617 0.510 rs2296300 chr1:183099701 G/A ch.1.3577855R chr1:183094577 LAMC1 0.89 15.86 0.66 1.84e-42 Fuchs's corneal dystrophy; CRC cis rs10927875 0.722 rs6660685 chr1:16346988 A/G cg22431228 chr1:16359049 CLCNKA -0.45 -8.05 -0.41 1.54e-14 Dilated cardiomyopathy; CRC cis rs9361491 1.000 rs9443648 chr6:79853605 C/T cg09184832 chr6:79620586 NA -0.32 -5.77 -0.3 1.88e-8 Intelligence (multi-trait analysis); CRC cis rs3617 0.573 rs9880978 chr3:52923251 C/G cg07507251 chr3:52567010 NT5DC2 0.4 6.31 0.33 9.06e-10 Red blood cell count;Autism spectrum disorder or schizophrenia; CRC cis rs67340775 0.541 rs169287 chr6:27854760 C/A cg06470822 chr6:28175283 NA 0.82 8.38 0.42 1.57e-15 Lung cancer in ever smokers; CRC cis rs10992471 0.756 rs7848055 chr9:95115492 A/C cg14631576 chr9:95140430 CENPP -0.39 -7.35 -0.38 1.53e-12 Visceral adipose tissue/subcutaneous adipose tissue ratio; CRC cis rs6460942 0.915 rs17541242 chr7:12459068 A/G cg20607287 chr7:12443886 VWDE -0.66 -6.93 -0.36 2.17e-11 Coronary artery disease; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg21551646 chr2:55921064 PNPT1 0.43 6.4 0.33 5.49e-10 Intelligence (multi-trait analysis); CRC cis rs951366 0.789 rs823130 chr1:205714372 C/T cg07167872 chr1:205819463 PM20D1 0.76 11.52 0.54 4.84e-26 Menarche (age at onset); CRC cis rs8060686 0.641 rs113162813 chr16:68038969 A/G cg08314208 chr16:67682810 RLTPR -0.64 -6.77 -0.35 5.77e-11 HDL cholesterol;Metabolic syndrome; CRC cis rs7208859 0.673 rs73265633 chr17:29236306 G/T cg14008862 chr17:28927542 LRRC37B2 0.56 5.8 0.3 1.6e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC trans rs9354308 0.933 rs2802063 chr6:66564148 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.47 5.99 0.31 5.47e-9 Metabolite levels; CRC cis rs10256972 0.521 rs7811577 chr7:1102829 C/G cg03188948 chr7:1209495 NA 0.4 6.05 0.32 3.99e-9 Longevity;Endometriosis; CRC cis rs9486719 1.000 rs12197411 chr6:97039621 G/A cg18709589 chr6:96969512 KIAA0776 -0.51 -5.81 -0.3 1.52e-8 Migraine;Coronary artery disease; CRC cis rs6502050 0.835 rs7209474 chr17:80136418 C/T cg13198984 chr17:80129470 CCDC57 0.46 7.98 0.4 2.45e-14 Life satisfaction; CRC cis rs60843830 1.000 rs55753056 chr2:243929 G/A cg00108164 chr2:264199 ACP1;SH3YL1 0.63 10.08 0.49 5.5e-21 Spherical equivalent (joint analysis main effects and education interaction); CRC cis rs950169 1.000 rs35658069 chr15:84780146 C/T cg24253500 chr15:84953950 NA 0.38 6.48 0.34 3.43e-10 Schizophrenia; CRC cis rs8018808 0.935 rs176772 chr14:77881808 A/G cg20045696 chr14:77926864 AHSA1 0.38 5.86 0.31 1.11e-8 Myeloid white cell count; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg21583412 chr17:27621436 NUFIP2 0.43 6.41 0.33 4.96e-10 Intelligence (multi-trait analysis); CRC cis rs79387448 0.614 rs985523 chr2:102954376 G/A cg09003973 chr2:102972529 NA 0.96 10.96 0.52 4.76e-24 Gut microbiota (bacterial taxa); CRC trans rs4824093 0.610 rs56810176 chr22:50303149 G/C cg09872104 chr7:134855509 C7orf49 -0.78 -7.57 -0.39 3.74e-13 Amyotrophic lateral sclerosis (sporadic); CRC cis rs7107174 1.000 rs10899460 chr11:78010080 A/G cg02023728 chr11:77925099 USP35 0.52 7.41 0.38 1.09e-12 Testicular germ cell tumor; CRC cis rs9291683 0.546 rs10939672 chr4:10052136 A/G cg11266682 chr4:10021025 SLC2A9 0.53 10.93 0.52 6.34e-24 Bone mineral density; CRC cis rs7940866 0.804 rs3910267 chr11:130810282 C/T cg12179176 chr11:130786555 SNX19 0.63 9.32 0.46 1.79e-18 Schizophrenia; CRC cis rs4789294 0.754 rs56280331 chr17:74403239 G/A cg06840243 chr17:74442338 UBE2O 0.44 6.26 0.33 1.22e-9 Lymphocyte percentage of white cells; CRC cis rs9911578 0.967 rs302842 chr17:56728102 C/G cg05425664 chr17:57184151 TRIM37 -0.5 -7.94 -0.4 3.16e-14 Intelligence (multi-trait analysis); CRC cis rs31872 0.521 rs246050 chr5:140326860 T/G cg19875535 chr5:140030758 IK 0.39 6.02 0.31 4.67e-9 Visceral adipose tissue adjusted for BMI; CRC cis rs4243830 0.850 rs10746502 chr1:6607199 A/G cg05709478 chr1:6581295 PLEKHG5 -0.56 -6.71 -0.35 8.54e-11 Body mass index; CRC cis rs10504229 1.000 rs60651159 chr8:58174074 T/C cg02290350 chr8:58132656 NA -0.42 -5.96 -0.31 6.62e-9 Developmental language disorder (linguistic errors); CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg18934641 chr7:99869784 GATS 0.47 6.51 0.34 2.89e-10 Anxiety disorder; CRC cis rs6570726 0.791 rs6913727 chr6:145899826 A/G cg13319975 chr6:146136371 FBXO30 -0.42 -6.19 -0.32 1.75e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs4925386 0.802 rs6142735 chr20:60918087 G/C cg15193198 chr20:60906057 LAMA5 -0.45 -6.65 -0.34 1.24e-10 Colorectal cancer;Colorectal cancer (SNP x SNP interaction); CRC cis rs939658 0.967 rs7172074 chr15:79452726 T/C cg17916960 chr15:79447300 NA 0.46 7.53 0.38 4.8e-13 Refractive error; CRC cis rs853679 1.000 rs853694 chr6:28279100 A/T cg21251018 chr6:28226885 NKAPL 0.49 5.67 0.3 3.06e-8 Depression; CRC cis rs365302 1.000 rs294917 chr6:159627077 C/T cg14500486 chr6:159655392 FNDC1 0.51 7.75 0.39 1.16e-13 Coronary heart disease; CRC cis rs6598955 0.543 rs4585968 chr1:26535146 G/A cg04990556 chr1:26633338 UBXN11 0.82 9.58 0.47 2.49e-19 Obesity-related traits; CRC cis rs10751667 0.621 rs11246345 chr11:934924 T/C ch.11.42038R chr11:967971 AP2A2 0.6 10.26 0.49 1.35e-21 Alzheimer's disease (late onset); CRC cis rs9296095 0.950 rs5745587 chr6:33545125 A/G cg14003231 chr6:33640908 ITPR3 0.49 7.15 0.37 5.69e-12 Platelet count; CRC cis rs2115630 1.000 rs2879828 chr15:85361977 G/T cg12501888 chr15:85177176 SCAND2 -0.36 -5.85 -0.31 1.22e-8 P wave terminal force; CRC cis rs6761276 0.899 rs6759676 chr2:113836348 A/G cg24553058 chr2:113831203 IL1F10 -0.39 -6.35 -0.33 7.24e-10 Protein quantitative trait loci; CRC cis rs2380220 0.935 rs7744491 chr6:95994980 T/G cg04719120 chr6:96025338 MANEA 0.64 7.34 0.38 1.71e-12 Behavioural disinhibition (generation interaction); CRC cis rs1448094 0.617 rs7297449 chr12:86468442 A/C cg02569458 chr12:86230093 RASSF9 -0.42 -7.14 -0.37 6.06e-12 Major depressive disorder; CRC cis rs2243480 1.000 rs2533288 chr7:66056711 C/G cg12463550 chr7:65579703 CRCP 0.67 6.08 0.32 3.4e-9 Diabetic kidney disease; CRC cis rs2204008 0.837 rs4432085 chr12:38181146 C/T cg26384229 chr12:38710491 ALG10B 0.71 9.53 0.47 3.56e-19 Bladder cancer; CRC cis rs873946 0.586 rs12767391 chr10:134573844 A/G cg26818010 chr10:134567672 INPP5A 0.67 8.69 0.43 1.72e-16 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CRC cis rs4819052 0.851 rs13049337 chr21:46663460 T/G cg02159808 chr21:46707872 POFUT2;LOC642852 0.5 6.59 0.34 1.76e-10 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs853679 0.517 rs9368556 chr6:28131153 T/C cg12172441 chr6:28176163 NA 0.64 7.53 0.38 5.03e-13 Depression; CRC cis rs10782582 0.532 rs78106188 chr1:76137836 A/G cg03433033 chr1:76189801 ACADM -0.42 -6.13 -0.32 2.51e-9 Daytime sleep phenotypes; CRC cis rs17234274 0.644 rs1482710 chr11:23219073 G/A cg05245346 chr11:23248277 NA 0.36 5.92 0.31 8.22e-9 Cancer; CRC cis rs55702914 0.746 rs7588530 chr2:198146698 A/C cg03934865 chr2:198174659 NA -0.42 -7.16 -0.37 5.46e-12 Major depression and alcohol dependence; CRC cis rs7829975 0.871 rs572307 chr8:8578811 T/C cg06636001 chr8:8085503 FLJ10661 -0.6 -9.53 -0.46 3.69e-19 Mood instability; CRC cis rs853679 1.000 rs853676 chr6:28299687 C/T cg21251018 chr6:28226885 NKAPL 0.49 5.61 0.3 4.23e-8 Depression; CRC cis rs1355223 0.583 rs2941060 chr11:34879154 G/A cg24088639 chr11:34937564 PDHX;APIP -0.59 -8.52 -0.43 5.76e-16 Systemic lupus erythematosus and Systemic sclerosis; CRC cis rs853679 0.506 rs1150693 chr6:28174590 T/C cg12172441 chr6:28176163 NA 0.66 8.55 0.43 4.66e-16 Depression; CRC trans rs11098499 0.908 rs71614449 chr4:120387055 C/T cg25214090 chr10:38739885 LOC399744 0.66 10.55 0.5 1.36e-22 Corneal astigmatism; CRC cis rs8060686 0.858 rs7199443 chr16:67841129 T/G cg00318322 chr16:67708822 GFOD2 -0.33 -6.14 -0.32 2.4e-9 HDL cholesterol;Metabolic syndrome; CRC cis rs7618915 0.501 rs10865974 chr3:52718280 A/C cg05573699 chr3:52720067 GNL3;PBRM1 0.49 7.32 0.37 1.91e-12 Bipolar disorder; CRC cis rs12286929 0.736 rs11215397 chr11:115044076 G/A cg04055981 chr11:115044050 NA 0.43 6.79 0.35 5.12e-11 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs8014204 0.604 rs11625594 chr14:75389833 G/A cg08847533 chr14:75593920 NEK9 0.49 6.94 0.36 2.04e-11 Caffeine consumption; CRC cis rs11679072 1.000 rs7573863 chr2:240448272 G/C cg03276489 chr2:240449683 NA -0.93 -9.41 -0.46 8.71e-19 Blood pressure (smoking interaction); CRC cis rs6570726 0.935 rs421690 chr6:145834594 A/C cg23711669 chr6:146136114 FBXO30 0.68 12.16 0.56 2.33e-28 Lobe attachment (rater-scored or self-reported); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg06550546 chr17:4166847 ANKFY1 0.42 6.01 0.31 4.91e-9 Response to antipsychotic treatment; CRC cis rs11190604 0.945 rs2495735 chr10:102338609 G/A cg07080220 chr10:102295463 HIF1AN 0.48 6.16 0.32 2.13e-9 Palmitoleic acid (16:1n-7) levels; CRC cis rs6728642 0.572 rs1320147 chr2:97600626 A/C cg26665480 chr2:98280029 ACTR1B 0.66 8.45 0.42 9.26e-16 Bipolar disorder lithium response (continuous) or schizophrenia; CRC cis rs2467099 1.000 rs2467099 chr17:73949045 C/T cg08125733 chr17:73851984 WBP2 0.53 5.73 0.3 2.31e-8 Systolic blood pressure; CRC cis rs28655083 0.529 rs285026 chr16:77100089 G/T cg01753188 chr16:77233325 SYCE1L;MON1B 0.48 6.8 0.35 4.89e-11 Lobe attachment (rater-scored or self-reported); CRC cis rs763121 0.853 rs5750677 chr22:39147715 C/T cg06022373 chr22:39101656 GTPBP1 0.8 12.31 0.56 6.48e-29 Menopause (age at onset); CRC cis rs12476592 0.571 rs2028883 chr2:63804531 G/A cg10828910 chr2:63850056 LOC388955 0.49 6.18 0.32 1.84e-9 Childhood ear infection; CRC cis rs2839186 0.559 rs2277826 chr21:47639492 C/G cg20399509 chr21:47717575 C21orf57 0.33 5.62 0.3 4.01e-8 Testicular germ cell tumor; CRC cis rs977987 0.806 rs4888386 chr16:75389740 A/G cg03315344 chr16:75512273 CHST6 0.49 8.36 0.42 1.75e-15 Dupuytren's disease; CRC cis rs2836974 0.568 rs371625 chr21:40535271 A/G cg06238570 chr21:40685208 BRWD1 -0.79 -12.75 -0.58 1.52e-30 Cognitive function; CRC cis rs826838 1.000 rs11168218 chr12:38884466 A/G cg26384229 chr12:38710491 ALG10B 0.76 10.52 0.5 1.63e-22 Heart rate; CRC cis rs11098499 0.954 rs1022145 chr4:120230979 A/G cg24375607 chr4:120327624 NA 0.49 7.42 0.38 1.01e-12 Corneal astigmatism; CRC cis rs367615 0.704 rs6889301 chr5:108835181 C/T cg17395555 chr5:108820864 NA 0.46 9.44 0.46 7.13e-19 Colorectal cancer (SNP x SNP interaction); CRC trans rs3942852 0.868 rs7118232 chr11:48106274 T/C cg15704280 chr7:45808275 SEPT13 -0.61 -7.18 -0.37 4.65e-12 Acute lymphoblastic leukemia (childhood); CRC cis rs478304 0.934 rs669742 chr11:65501291 C/T cg08755490 chr11:65554678 OVOL1 0.43 6.39 0.33 5.53e-10 Acne (severe); CRC cis rs9916302 0.851 rs11657899 chr17:37626963 G/A cg00129232 chr17:37814104 STARD3 -0.55 -8.17 -0.41 6.79e-15 Glomerular filtration rate (creatinine); CRC cis rs1322512 1.000 rs1322512 chr6:152947953 C/A cg03415253 chr6:152958462 SYNE1 -0.41 -6.37 -0.33 6.5e-10 Tonometry; CRC cis rs1580019 0.587 rs2392069 chr7:32547154 A/G cg14728415 chr7:32535168 LSM5;AVL9 0.45 6.48 0.34 3.28e-10 Cognitive ability; CRC cis rs1046896 0.594 rs8070403 chr17:80865404 A/G cg16060761 chr17:80687452 NA -0.47 -6.06 -0.32 3.7e-9 Glycated hemoglobin levels; CRC trans rs10242455 0.702 rs57832867 chr7:98966396 C/T cg09045935 chr12:6379348 NA 0.9 7.09 0.36 8.37e-12 Blood metabolite levels; CRC cis rs1008375 1.000 rs2058337 chr4:17678649 C/T cg04450456 chr4:17643702 FAM184B 0.38 5.99 0.31 5.52e-9 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs9816226 0.590 rs872602 chr3:185826028 A/G cg00760338 chr3:185826511 ETV5 0.79 10.97 0.52 4.59e-24 Obesity;Body mass index; CRC cis rs6500602 0.627 rs6500610 chr16:4529613 A/G cg08645402 chr16:4508243 NA 0.54 8.02 0.4 1.85e-14 Schizophrenia; CRC cis rs1218582 0.804 rs4845398 chr1:154859038 G/C cg06221963 chr1:154839813 KCNN3 -0.77 -15.49 -0.65 5.1e-41 Prostate cancer; CRC cis rs7677751 0.806 rs4864862 chr4:55100489 G/A cg17187183 chr4:55093834 PDGFRA 0.51 7.27 0.37 2.72e-12 Corneal astigmatism; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg09706180 chr15:50647709 GABPB1;FLJ10038;LOC100129387 0.41 7.22 0.37 3.64e-12 Liver disease severity in Alagille syndrome; CRC cis rs2294693 0.898 rs6458195 chr6:40972498 A/T cg14769373 chr6:40998127 UNC5CL 0.47 6.5 0.34 2.97e-10 Gastric cancer;Non-cardia gastric cancer; CRC cis rs1223397 0.938 rs3817742 chr6:13279552 T/C cg00460589 chr6:13274354 PHACTR1 0.48 5.97 0.31 6.28e-9 Blood pressure; CRC trans rs17685 0.593 rs56265719 chr7:75796269 C/T cg19862616 chr7:65841803 NCRNA00174 0.93 16.02 0.66 4.19e-43 Coffee consumption;Coffee consumption (cups per day); CRC cis rs7781266 0.690 rs1628880 chr7:133069285 A/T cg03336402 chr7:133662267 EXOC4 0.5 6.11 0.32 2.81e-9 Educational attainment (college completion); CRC cis rs9402673 0.558 rs9688342 chr6:135323026 A/T cg22676075 chr6:135203613 NA 0.42 6.51 0.34 2.78e-10 Reticulocyte count;High light scatter reticulocyte count; CRC cis rs9660180 0.935 rs9786942 chr1:1759213 A/G cg17747265 chr1:1875780 NA -0.76 -12.83 -0.58 8.19e-31 Body mass index; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg14729455 chr14:53019147 TXNDC16;GPR137C 0.42 6.16 0.32 2.09e-9 Intelligence (multi-trait analysis); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg22479947 chr11:3078624 CARS 0.42 6.76 0.35 6.43e-11 Liver disease severity in Alagille syndrome; CRC cis rs2304069 0.507 rs13167061 chr5:149388624 T/G cg22760475 chr5:149380129 HMGXB3;TIGD6 0.46 6.72 0.35 8.25e-11 HIV-1 control; CRC cis rs6951245 0.572 rs73265911 chr7:1055363 G/A cg24642844 chr7:1081250 C7orf50 -0.58 -6.26 -0.33 1.19e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs2404602 0.647 rs11072607 chr15:76908529 C/T cg23625390 chr15:77176239 SCAPER -0.88 -14.28 -0.62 2.52e-36 Blood metabolite levels; CRC cis rs853679 0.550 rs1233707 chr6:28172953 G/A cg23161317 chr6:28129485 ZNF389 0.44 5.85 0.31 1.17e-8 Depression; CRC cis rs11785693 0.862 rs10503292 chr8:4992275 A/G cg26367366 chr8:4980734 NA 0.49 6.12 0.32 2.7e-9 Neuroticism (multi-trait analysis);Neuroticism; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg06474646 chr7:128864675 AHCYL2 -0.42 -6.05 -0.32 3.89e-9 Myopia (pathological); CRC cis rs1801251 0.778 rs812383 chr2:233737132 C/A cg25237894 chr2:233734115 C2orf82 -0.63 -11.13 -0.52 1.23e-24 Coronary artery disease; CRC trans rs2243480 1.000 rs6959002 chr7:65650496 A/G cg10756647 chr7:56101905 PSPH -0.76 -7.87 -0.4 5.31e-14 Diabetic kidney disease; CRC trans rs6550704 0.687 rs9865314 chr3:22634337 A/G cg02832646 chr16:81040020 CENPN;C16orf61 -0.41 -6.01 -0.31 5.04e-9 Daytime sleep phenotypes; CRC cis rs13118159 0.550 rs2336081 chr4:1350322 A/G cg20887711 chr4:1340912 KIAA1530 -0.75 -10.92 -0.52 6.56e-24 Longevity; CRC cis rs4363385 0.791 rs3120744 chr1:153010330 G/A cg25856811 chr1:152973957 SPRR3 -0.25 -6.99 -0.36 1.51e-11 Inflammatory skin disease; CRC trans rs875971 0.545 rs1267814 chr7:66044409 G/A cg02869306 chr7:64672164 INTS4L1 0.43 6.23 0.32 1.39e-9 Aortic root size; CRC cis rs11098499 0.863 rs6534139 chr4:120449456 A/G cg09307838 chr4:120376055 NA -0.66 -9.81 -0.48 4.27e-20 Corneal astigmatism; CRC cis rs10512697 0.764 rs35866886 chr5:3556681 A/G cg19473799 chr5:3511975 NA -0.72 -5.66 -0.3 3.22e-8 Immune response to smallpox vaccine (IL-6); CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg16782848 chr15:83479213 WHAMM 0.36 6.17 0.32 2.04e-9 Obesity-related traits; CRC cis rs2243480 1.000 rs427044 chr7:65508545 G/A cg12463550 chr7:65579703 CRCP 0.72 6.58 0.34 1.9e-10 Diabetic kidney disease; CRC cis rs10046574 0.561 rs56014861 chr7:135203027 A/T cg27474649 chr7:135195673 CNOT4 0.66 6.21 0.32 1.58e-9 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs6752107 0.967 rs12162308 chr2:234172188 C/G cg07618928 chr2:234183455 ATG16L1;SCARNA5 0.66 11.41 0.53 1.27e-25 Crohn's disease;Inflammatory bowel disease; CRC cis rs941408 0.515 rs7253128 chr19:2776982 C/T cg06609049 chr19:2785107 THOP1 0.98 16.34 0.67 2.38e-44 Total cholesterol levels; CRC cis rs3820068 0.581 rs72645889 chr1:15930251 T/G cg24675056 chr1:15929824 NA 0.49 6.77 0.35 5.87e-11 Systolic blood pressure; CRC cis rs7937682 0.632 rs4441050 chr11:111772506 C/T cg09085632 chr11:111637200 PPP2R1B 0.94 14.87 0.63 1.28e-38 Primary sclerosing cholangitis; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg22401940 chr2:169103153 STK39 0.46 6.96 0.36 1.85e-11 Intelligence (multi-trait analysis); CRC cis rs7843479 0.601 rs11785043 chr8:21810377 C/T cg17168535 chr8:21777572 XPO7 0.6 10.15 0.49 3.09e-21 Mean corpuscular volume; CRC cis rs7769051 0.808 rs1467404 chr6:133090141 A/G cg07930552 chr6:133119739 C6orf192 -0.6 -7.27 -0.37 2.65e-12 Type 2 diabetes nephropathy; CRC cis rs2046867 0.818 rs6808341 chr3:72914847 A/G cg25664220 chr3:72788482 NA -0.44 -6.62 -0.34 1.49e-10 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; CRC cis rs7618915 0.524 rs2028216 chr3:52680823 C/T cg10802521 chr3:52805072 NEK4 -0.58 -8.85 -0.44 5.34e-17 Bipolar disorder; CRC cis rs6831352 0.879 rs7672728 chr4:100055173 A/G cg12011299 chr4:100065546 ADH4 -0.49 -9.27 -0.45 2.61e-18 Alcohol dependence; CRC cis rs4975709 0.589 rs1684967 chr5:1863055 G/C cg14024788 chr5:1875611 NA 0.37 5.83 0.31 1.29e-8 Cardiovascular disease risk factors; CRC cis rs9926296 0.565 rs8055825 chr16:89832848 C/T cg03388025 chr16:89894329 SPIRE2 0.42 8.31 0.42 2.53e-15 Vitiligo; CRC cis rs9914988 0.943 rs4313850 chr17:27080768 T/C cg12682573 chr17:27188876 MIR451;MIR144 0.57 7.84 0.4 6.26e-14 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs4555082 0.957 rs2975216 chr14:105713134 T/C cg13114125 chr14:105738426 BRF1 -0.74 -11.19 -0.52 7.75e-25 Mean platelet volume;Platelet distribution width; CRC cis rs12620999 0.774 rs7584900 chr2:237957112 T/G cg23555395 chr2:238036564 NA 0.5 7.8 0.4 8.01e-14 Systemic lupus erythematosus; CRC cis rs4629710 0.592 rs3777476 chr6:131533821 A/C cg12606694 chr6:131520996 AKAP7 0.58 8.53 0.43 5.54e-16 Multiple myeloma (IgH translocation); CRC cis rs1670533 1.000 rs10084888 chr4:1053814 G/T cg27284194 chr4:1044797 NA 0.5 6.2 0.32 1.66e-9 Recombination rate (females); CRC cis rs916888 0.773 rs199447 chr17:44812188 C/T cg01570182 chr17:44337453 NA 1.26 14.75 0.63 3.64e-38 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs2404602 0.647 rs12904417 chr15:76964152 A/G cg23625390 chr15:77176239 SCAPER 0.87 14.38 0.62 1e-36 Blood metabolite levels; CRC cis rs28386778 0.897 rs4638645 chr17:61828349 T/C cg06601766 chr17:61851465 DDX42;CCDC47 0.45 6.1 0.32 3.06e-9 Prudent dietary pattern; CRC cis rs9814567 0.806 rs4074521 chr3:134325536 G/A cg06109529 chr3:134205091 CEP63;ANAPC13 0.68 9.86 0.48 2.86e-20 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs172166 0.694 rs1770131 chr6:28086413 C/T cg02683197 chr6:28174875 NA 0.68 9.38 0.46 1.09e-18 Cardiac Troponin-T levels; CRC cis rs2842992 0.662 rs2273825 chr6:160211424 A/C cg16489826 chr6:160211363 TCP1;MRPL18 0.61 8.99 0.44 1.94e-17 Age-related macular degeneration (geographic atrophy); CRC cis rs763121 0.853 rs3747170 chr22:39067331 G/A cg06022373 chr22:39101656 GTPBP1 0.79 12.65 0.57 3.55e-30 Menopause (age at onset); CRC cis rs2228479 0.681 rs2270461 chr16:89972345 C/T cg06558623 chr16:89946397 TCF25 -0.56 -6.62 -0.34 1.47e-10 Skin colour saturation; CRC cis rs2882667 0.898 rs6882583 chr5:138385796 C/T cg09476006 chr5:138032270 NA 0.44 7.37 0.38 1.35e-12 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs909002 0.772 rs12740754 chr1:32083273 G/C cg01639898 chr1:32083012 HCRTR1 0.29 6.03 0.32 4.47e-9 Intelligence (multi-trait analysis); CRC cis rs561341 1.000 rs535151 chr17:30317405 C/T cg00745463 chr17:30367425 LRRC37B -0.61 -7.86 -0.4 5.66e-14 Hip circumference adjusted for BMI; CRC cis rs853679 0.760 rs11962305 chr6:28199937 G/C cg15786705 chr6:28176104 NA 0.65 6.92 0.36 2.38e-11 Depression; CRC cis rs1799949 0.965 rs8176323 chr17:41195711 G/C cg01879757 chr17:41196368 BRCA1 -0.41 -6.21 -0.32 1.63e-9 Menopause (age at onset); CRC cis rs8180040 0.966 rs2291298 chr3:47555142 C/A cg10298567 chr3:47292165 KIF9 -0.36 -5.93 -0.31 7.58e-9 Colorectal cancer; CRC cis rs7824557 0.564 rs6601584 chr8:11232343 C/G cg20542592 chr8:11973495 FAM66D 0.33 5.85 0.31 1.18e-8 Retinal vascular caliber; CRC cis rs6604026 0.656 rs2774950 chr1:93353527 T/C cg17283838 chr1:93427260 FAM69A -0.43 -5.79 -0.3 1.61e-8 Multiple sclerosis; CRC trans rs2797369 0.882 rs2797368 chr6:101672809 T/C cg26346621 chr12:6873348 NA -0.4 -6.0 -0.31 5.15e-9 Renal function-related traits (eGRFcrea); CRC cis rs763014 0.966 rs4247097 chr16:654224 G/A cg00908189 chr16:619842 PIGQ 0.68 11.4 0.53 1.39e-25 Height; CRC trans rs4942242 0.663 rs34595450 chr13:44221245 A/G cg27382691 chr15:76552771 ETFA;TYRO3P -0.47 -6.05 -0.32 3.98e-9 Response to tocilizumab in rheumatoid arthritis; CRC cis rs1862618 0.756 rs832548 chr5:56183637 G/C cg24531977 chr5:56204891 C5orf35 -0.84 -10.92 -0.52 6.54e-24 Initial pursuit acceleration; CRC cis rs6502050 0.835 rs66531647 chr17:80089022 G/T cg09264619 chr17:80180166 NA -0.36 -6.09 -0.32 3.09e-9 Life satisfaction; CRC cis rs67478160 0.643 rs2024667 chr14:104211529 T/G cg08213375 chr14:104286397 PPP1R13B 0.65 13.93 0.61 5.48e-35 Schizophrenia; CRC cis rs13256369 1.000 rs12545771 chr8:8567977 C/G cg18904891 chr8:8559673 CLDN23 0.52 6.89 0.35 2.9e-11 Obesity-related traits; CRC trans rs7944735 0.517 rs1827503 chr11:48225115 G/T cg27395922 chr11:50257633 LOC441601 0.48 6.07 0.32 3.53e-9 Intraocular pressure; CRC cis rs6582630 0.555 rs35284307 chr12:38509999 T/G cg26384229 chr12:38710491 ALG10B 0.71 10.1 0.49 4.6e-21 Drug-induced liver injury (flucloxacillin); CRC cis rs9467711 0.517 rs16901784 chr6:26555433 C/A cg16898833 chr6:26189333 HIST1H4D 0.82 7.19 0.37 4.44e-12 Autism spectrum disorder or schizophrenia; CRC trans rs7937682 0.855 rs11213985 chr11:111581521 C/A cg18187862 chr3:45730750 SACM1L 0.46 6.68 0.35 1.04e-10 Primary sclerosing cholangitis; CRC cis rs4481887 0.927 rs4409694 chr1:248485498 C/T cg13385794 chr1:248469461 NA 0.39 6.85 0.35 3.57e-11 Common traits (Other); CRC cis rs1580019 0.844 rs4723159 chr7:32512804 T/C cg07520158 chr7:32535189 LSM5;AVL9 0.5 6.81 0.35 4.54e-11 Cognitive ability; CRC cis rs4073582 0.595 rs1151540 chr11:66041807 A/C cg16950941 chr11:66035639 RAB1B 0.71 12.12 0.56 3.48e-28 Gout; CRC cis rs4713118 0.824 rs2179095 chr6:27750858 A/G cg03623178 chr6:28175578 NA -0.7 -9.32 -0.46 1.78e-18 Parkinson's disease; CRC cis rs4148883 0.675 rs116265877 chr4:100096896 G/A cg12011299 chr4:100065546 ADH4 0.5 10.97 0.52 4.61e-24 Alcohol dependence; CRC cis rs11148252 0.574 rs3742297 chr13:53278067 T/C cg12458913 chr13:53173898 NA 0.8 14.88 0.63 1.15e-38 Lewy body disease; CRC cis rs1005277 0.579 rs2474594 chr10:38426661 G/C cg17219203 chr10:38645113 HSD17B7P2 -0.4 -5.67 -0.3 3.07e-8 Extrinsic epigenetic age acceleration; CRC cis rs62244186 0.659 rs12489887 chr3:44547124 A/T cg10263370 chr3:44754102 ZNF502 -0.36 -5.96 -0.31 6.54e-9 Depressive symptoms; CRC cis rs6964587 1.000 rs10280927 chr7:91582205 G/A cg17063962 chr7:91808500 NA -0.79 -13.8 -0.61 1.73e-34 Breast cancer; CRC cis rs524281 0.731 rs78578425 chr11:65810239 G/A cg16950941 chr11:66035639 RAB1B -0.54 -5.81 -0.31 1.47e-8 Electroencephalogram traits; CRC cis rs1572438 0.831 rs17139761 chr6:856766 A/G cg13447295 chr6:887704 NA -0.43 -6.55 -0.34 2.24e-10 Aging; CRC cis rs6952808 0.760 rs11764960 chr7:1950532 G/A cg20295408 chr7:1910781 MAD1L1 -0.43 -5.95 -0.31 6.9e-9 Bipolar disorder and schizophrenia; CRC trans rs3733585 0.605 rs4697708 chr4:10121189 A/G cg26043149 chr18:55253948 FECH -0.53 -7.47 -0.38 7.23e-13 Cleft plate (environmental tobacco smoke interaction); CRC cis rs919433 0.963 rs4850430 chr2:198182796 A/T cg20885578 chr2:198174922 NA -0.42 -6.69 -0.35 9.64e-11 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC cis rs1057239 0.510 rs3766694 chr1:175143207 T/C cg00321850 chr1:175162397 KIAA0040 -0.44 -7.38 -0.38 1.33e-12 Diastolic blood pressure; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg04046427 chr10:75254985 PPP3CB 0.41 6.38 0.33 5.88e-10 Liver disease severity in Alagille syndrome; CRC cis rs763014 0.966 rs7185390 chr16:666382 A/G cg18653534 chr16:772142 FAM173A -0.39 -6.16 -0.32 2.09e-9 Height; CRC cis rs274567 0.501 rs274571 chr5:131712125 A/G cg27615366 chr5:131592974 PDLIM4 -0.32 -5.63 -0.3 3.78e-8 Blood metabolite levels; CRC cis rs17345786 0.906 rs56171035 chr3:101111108 G/C cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.58 6.83 0.35 4.04e-11 Colonoscopy-negative controls vs population controls; CRC cis rs2380220 0.510 rs9387562 chr6:96057006 G/T cg23517279 chr6:96025343 MANEA 0.57 6.49 0.34 3.24e-10 Behavioural disinhibition (generation interaction); CRC cis rs12188164 0.930 rs72717440 chr5:449701 A/T cg16322479 chr5:444228 EXOC3;C5orf55 0.51 8.4 0.42 1.38e-15 Cystic fibrosis severity; CRC cis rs58688157 0.880 rs12272314 chr11:590648 A/G cg16486109 chr11:613632 IRF7 0.68 12.6 0.57 5.55e-30 Systemic lupus erythematosus; CRC cis rs727563 0.635 rs713988 chr22:42159072 A/G cg03806693 chr22:41940476 POLR3H 1.1 13.51 0.6 2.16e-33 Crohn's disease;Inflammatory bowel disease; CRC cis rs6502050 0.799 rs7502524 chr17:80107261 C/T cg13198984 chr17:80129470 CCDC57 0.46 8.16 0.41 6.94e-15 Life satisfaction; CRC cis rs13108904 0.967 rs900029 chr4:1279145 C/T cg05665937 chr4:1216051 CTBP1 0.41 5.93 0.31 7.85e-9 Obesity-related traits; CRC cis rs950169 1.000 rs11638297 chr15:84782417 A/C cg17507749 chr15:85114479 UBE2QP1 0.77 11.87 0.55 2.83e-27 Schizophrenia; CRC trans rs2243480 0.764 rs2460423 chr7:65601216 A/T cg10756647 chr7:56101905 PSPH 0.74 7.77 0.39 9.82e-14 Diabetic kidney disease; CRC cis rs887829 0.569 rs2008595 chr2:234637192 C/T cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.47 -7.39 -0.38 1.24e-12 Metabolic traits;Bilirubin levels;Cholelithiasis-related traits in sickle cell anemia;Metabolite levels;Total bilirubin levels in HIV-1 infection;Serum metabolite levels;Blood metabolite levels; CRC trans rs3858526 0.959 rs4758219 chr11:5951846 G/C cg01505111 chr6:125621795 HDDC2 0.38 6.04 0.32 4.06e-9 DNA methylation (variation); CRC cis rs9938149 0.706 rs8059024 chr16:88314163 T/C cg05435882 chr16:88311214 NA -0.44 -5.82 -0.31 1.39e-8 Corneal structure;Central corneal thickness; CRC cis rs703980 0.967 rs703967 chr10:80953451 A/C cg20744163 chr10:80999841 ZMIZ1 0.32 5.88 0.31 1e-8 Type 2 diabetes; CRC cis rs769267 0.899 rs67720221 chr19:19440864 C/T cg20644253 chr19:19431407 KIAA0892;SF4 -0.41 -5.61 -0.3 4.25e-8 Tonsillectomy; CRC cis rs477895 0.938 rs28395875 chr11:64024048 G/C cg23719950 chr11:63933701 MACROD1 -0.55 -5.88 -0.31 9.97e-9 Mean platelet volume; CRC cis rs6120849 0.754 rs6120813 chr20:33642112 T/C cg08999081 chr20:33150536 PIGU 0.44 5.72 0.3 2.39e-8 Protein C levels; CRC cis rs1046896 0.594 rs9914570 chr17:80783721 C/T cg08200770 chr17:80723486 TBCD -0.51 -7.69 -0.39 1.74e-13 Glycated hemoglobin levels; CRC cis rs965469 0.817 rs6037582 chr20:3351696 C/T cg25506879 chr20:3388711 C20orf194 -0.37 -5.73 -0.3 2.26e-8 IFN-related cytopenia; CRC cis rs796364 0.951 rs281793 chr2:200847990 G/A cg12253985 chr2:200820533 C2orf60;C2orf47 0.58 6.3 0.33 9.76e-10 Schizophrenia; CRC cis rs2019137 0.560 rs11123172 chr2:113984303 C/T cg23564664 chr2:113997917 PAX8;LOC654433;LOC440839 0.36 5.87 0.31 1.04e-8 Lymphocyte counts; CRC cis rs1950626 0.750 rs12895798 chr14:101442793 T/C cg02351406 chr14:101447389 SNORD114-20;SNORD114-21 0.96 15.65 0.65 1.23e-41 Pelvic organ prolapse (moderate/severe); CRC cis rs10979 0.679 rs9496680 chr6:143896915 G/A cg25407410 chr6:143891975 LOC285740 -0.72 -10.41 -0.5 4.04e-22 Hypospadias; CRC cis rs41271951 0.512 rs116666233 chr1:151056058 C/T cg11822372 chr1:151115635 SEMA6C -0.7 -5.62 -0.3 4.02e-8 Blood protein levels; CRC cis rs11122272 0.766 rs1435166 chr1:231502310 T/C cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.58 -8.89 -0.44 4.05e-17 Hemoglobin concentration; CRC cis rs6662572 0.671 rs11211220 chr1:46365501 G/A cg08644498 chr1:46502608 NA -0.43 -6.67 -0.35 1.05e-10 Blood protein levels; CRC cis rs2204008 0.687 rs11181339 chr12:38322271 G/T cg13010199 chr12:38710504 ALG10B 0.48 6.88 0.35 2.98e-11 Bladder cancer; CRC cis rs13082711 0.911 rs6797389 chr3:27502070 G/T cg02860705 chr3:27208620 NA 0.62 8.64 0.43 2.56e-16 Systolic blood pressure;Diastolic blood pressure;Blood pressure; CRC cis rs2976388 0.556 rs4736300 chr8:143829269 C/T cg20041105 chr8:143859282 LYNX1 -0.41 -6.61 -0.34 1.52e-10 Urinary tract infection frequency; CRC cis rs6495367 0.966 rs745029 chr15:79381779 C/T cg17916960 chr15:79447300 NA 0.39 6.35 0.33 7.22e-10 Spherical equivalent (joint analysis main effects and education interaction); CRC cis rs10782582 0.617 rs1846233 chr1:76159354 C/T cg10523679 chr1:76189770 ACADM -0.41 -5.79 -0.3 1.69e-8 Daytime sleep phenotypes; CRC cis rs727505 1.000 rs10233385 chr7:124498707 C/G cg23710748 chr7:124431027 NA -0.8 -14.18 -0.62 6.24e-36 Lewy body disease; CRC trans rs75804782 0.641 rs112066551 chr2:239362486 G/A cg01134436 chr17:81009848 B3GNTL1 0.7 6.42 0.33 4.8e-10 Morning vs. evening chronotype;Chronotype; CRC cis rs12476592 0.602 rs262477 chr2:63870959 A/C cg10828910 chr2:63850056 LOC388955 0.5 6.15 0.32 2.31e-9 Childhood ear infection; CRC cis rs1568889 1.000 rs12804198 chr11:28143114 C/A cg06544937 chr11:28130018 METT5D1;KIF18A 0.79 11.03 0.52 2.83e-24 Bipolar disorder; CRC cis rs2072499 0.966 rs2842864 chr1:156159217 G/A cg25208724 chr1:156163844 SLC25A44 1.1 26.81 0.83 9.1200000000000006e-85 Testicular germ cell tumor; CRC cis rs3796352 0.527 rs11714793 chr3:52924930 A/G cg06204229 chr3:52865917 ITIH4 0.52 6.74 0.35 7.26e-11 Immune reponse to smallpox (secreted IL-2); CRC cis rs12130219 0.500 rs1552991 chr1:152165878 C/T cg17718321 chr1:152188247 HRNR -0.34 -7.41 -0.38 1.07e-12 Inflammatory skin disease; CRC cis rs4689592 0.554 rs3951346 chr4:7073321 C/T cg19539972 chr4:7069911 GRPEL1 0.77 10.4 0.5 4.3e-22 Monocyte percentage of white cells; CRC cis rs11098499 0.909 rs7681214 chr4:120385320 C/A cg09307838 chr4:120376055 NA 0.71 10.92 0.52 6.75e-24 Corneal astigmatism; CRC cis rs738322 1.000 rs4379 chr22:38569171 T/C cg03162506 chr22:38580953 NA 0.26 5.69 0.3 2.77e-8 Cutaneous nevi; CRC cis rs910316 0.967 rs10246 chr14:75544470 T/A cg11812906 chr14:75593930 NEK9 0.62 9.87 0.48 2.72e-20 Height; CRC cis rs9372498 0.536 rs9489452 chr6:118910868 G/C cg22561889 chr6:118971681 C6orf204 0.5 6.52 0.34 2.69e-10 Diastolic blood pressure; CRC cis rs6840360 0.593 rs59350867 chr4:152695935 G/A cg09659197 chr4:152720779 NA 0.39 8.14 0.41 8.49e-15 Intelligence (multi-trait analysis); CRC cis rs2228479 0.717 rs1007932 chr16:89838541 C/T cg06558623 chr16:89946397 TCF25 0.97 9.89 0.48 2.27e-20 Skin colour saturation; CRC cis rs1129187 0.902 rs6907751 chr6:42944850 C/T cg03790207 chr6:42947109 PEX6 -0.46 -6.6 -0.34 1.64e-10 Alzheimer's disease in APOE e4+ carriers; CRC cis rs6748734 0.779 rs6437371 chr2:241797424 G/C cg04034577 chr2:241836375 C2orf54 -0.35 -7.47 -0.38 7.51e-13 Urinary metabolites; CRC cis rs2075371 0.796 rs1646644 chr7:134011817 A/T cg20476274 chr7:133979776 SLC35B4 0.67 10.8 0.51 1.84e-23 Mean platelet volume; CRC cis rs11764590 0.715 rs9639202 chr7:2087315 G/A cg13880726 chr7:1868755 MAD1L1 -0.47 -5.81 -0.31 1.46e-8 Neuroticism; CRC cis rs12682352 0.535 rs12677550 chr8:8644322 A/G cg06636001 chr8:8085503 FLJ10661 -0.45 -6.82 -0.35 4.27e-11 Neuroticism; CRC cis rs7178572 1.000 rs965480 chr15:77781926 A/G cg22256960 chr15:77711686 NA -0.69 -10.8 -0.51 1.8e-23 Type 2 diabetes; CRC cis rs35306767 0.807 rs34982663 chr10:852521 C/G cg26597838 chr10:835615 NA 1.3 15.04 0.64 2.92e-39 Eosinophil percentage of granulocytes; CRC cis rs754466 0.651 rs56138814 chr10:79625795 T/C cg17075019 chr10:79541650 NA -0.89 -15.36 -0.65 1.55e-40 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs9611565 0.512 rs6519289 chr22:42170432 A/C cg06481639 chr22:41940642 POLR3H 0.56 6.21 0.32 1.57e-9 Vitiligo; CRC cis rs6772849 0.931 rs60825080 chr3:128384834 G/T cg08795948 chr3:128337044 NA 0.36 6.1 0.32 2.92e-9 Monocyte percentage of white cells;Monocyte count; CRC cis rs9381040 1.000 rs9381040 chr6:41154650 C/T cg09580153 chr6:41068724 NFYA;LOC221442 -0.52 -7.2 -0.37 4.07e-12 Alzheimer's disease (late onset); CRC cis rs2180341 1.000 rs2038378 chr6:127590400 C/T cg24812749 chr6:127587940 RNF146 0.93 13.36 0.59 8.14e-33 Breast cancer; CRC cis rs2857891 0.697 rs1004754 chr11:6946248 T/C cg22096450 chr11:6947773 ZNF215 0.59 6.1 0.32 3.03e-9 Response to cytadine analogues (cytosine arabinoside); CRC trans rs11098499 0.865 rs9994730 chr4:120381564 A/C cg25214090 chr10:38739885 LOC399744 0.66 10.58 0.5 1.07e-22 Corneal astigmatism; CRC cis rs6502050 0.723 rs11650633 chr17:80083807 T/C cg11859384 chr17:80120422 CCDC57 0.37 5.75 0.3 2.05e-8 Life satisfaction; CRC cis rs10504229 1.000 rs17217033 chr8:58180061 G/T cg02725872 chr8:58115012 NA -0.38 -6.43 -0.33 4.44e-10 Developmental language disorder (linguistic errors); CRC trans rs1005277 0.579 rs2983343 chr10:38383332 A/G cg27523141 chr10:43048294 ZNF37B 0.5 7.23 0.37 3.41e-12 Extrinsic epigenetic age acceleration; CRC cis rs2386661 0.547 rs11259540 chr10:5646706 A/T cg12223502 chr10:5658492 NA -0.37 -5.93 -0.31 7.77e-9 Breast cancer; CRC cis rs12887734 0.524 rs4900599 chr14:104283444 G/T cg08213375 chr14:104286397 PPP1R13B 0.5 8.62 0.43 2.96e-16 Schizophrenia;Autism spectrum disorder or schizophrenia; CRC cis rs10256972 0.552 rs7805591 chr7:1210745 A/G cg18765753 chr7:1198926 ZFAND2A -0.42 -7.31 -0.37 2e-12 Longevity;Endometriosis; CRC cis rs7224685 0.501 rs781823 chr17:3966280 G/C cg09695851 chr17:3907499 NA 0.76 14.45 0.62 5.69e-37 Type 2 diabetes; CRC cis rs66573146 0.572 rs67922134 chr4:6955772 G/A cg00086871 chr4:6988644 TBC1D14 0.86 8.28 0.42 3.15e-15 Granulocyte percentage of myeloid white cells; CRC cis rs875971 0.638 rs801205 chr7:66022144 C/A cg25985355 chr7:65971099 NA 0.32 5.67 0.3 3.12e-8 Aortic root size; CRC cis rs2227564 0.649 rs2243610 chr10:75601653 A/T cg16540259 chr10:75572220 NDST2 0.46 6.67 0.35 1.05e-10 Crohn's disease;Inflammatory bowel disease; CRC cis rs11764590 0.694 rs10235664 chr7:2086814 T/C cg23422044 chr7:1970798 MAD1L1 -0.4 -5.62 -0.3 4.18e-8 Neuroticism; CRC cis rs853679 0.760 rs11967137 chr6:28199764 A/G cg12273811 chr6:28175739 NA 0.54 5.81 0.3 1.5e-8 Depression; CRC cis rs9393692 0.905 rs9379843 chr6:26289435 A/G cg00631329 chr6:26305371 NA -0.7 -13.54 -0.6 1.68e-33 Educational attainment; CRC cis rs13082711 0.911 rs34098124 chr3:27451242 G/T cg02860705 chr3:27208620 NA 0.6 8.39 0.42 1.43e-15 Systolic blood pressure;Diastolic blood pressure;Blood pressure; CRC cis rs977987 0.806 rs4887824 chr16:75441613 T/C cg03315344 chr16:75512273 CHST6 0.54 9.08 0.45 1.01e-17 Dupuytren's disease; CRC cis rs2072499 0.931 rs1052053 chr1:156202173 A/G cg24450063 chr1:156163899 SLC25A44 1.04 22.23 0.77 1.79e-67 Testicular germ cell tumor; CRC cis rs12286929 0.610 rs12807135 chr11:115053508 G/C cg04055981 chr11:115044050 NA 0.39 6.01 0.31 5.02e-9 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs601339 1.000 rs525215 chr12:123179771 G/A cg22192744 chr12:123187474 GPR109A -0.4 -5.66 -0.3 3.25e-8 Adiponectin levels; CRC cis rs6762 0.719 rs28655651 chr11:837121 G/C cg07691484 chr11:842764 TSPAN4;POLR2L -0.57 -8.41 -0.42 1.29e-15 Mean platelet volume; CRC cis rs9303542 0.559 rs2326012 chr17:46618581 C/T cg04904318 chr17:46607828 HOXB1 -0.49 -6.02 -0.32 4.55e-9 Ovarian cancer;Epithelial ovarian cancer; CRC cis rs7635838 0.596 rs443503 chr3:11261912 A/T cg00170343 chr3:11313890 ATG7 -0.54 -8.25 -0.41 3.93e-15 HDL cholesterol; CRC cis rs6502050 0.731 rs12150589 chr17:80158233 A/T cg09264619 chr17:80180166 NA -0.36 -6.1 -0.32 3e-9 Life satisfaction; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg11480627 chr11:70672876 SHANK2 0.37 7.85 0.4 5.83e-14 Liver disease severity in Alagille syndrome; CRC cis rs6499255 0.951 rs10163235 chr16:69739867 G/T cg15192750 chr16:69999425 NA 0.55 7.38 0.38 1.26e-12 IgE levels; CRC cis rs174601 0.668 rs174559 chr11:61581656 G/A cg00603274 chr11:61596626 FADS2 -0.55 -7.59 -0.39 3.22e-13 Blood metabolite levels;Red blood cell fatty acid levels;Liver enzyme levels (alkaline phosphatase);Gondoic acid (20:1n-9) levels;Trans fatty acid levels; CRC cis rs9467773 0.587 rs12214031 chr6:26376628 T/C cg09904177 chr6:26538194 HMGN4 -0.46 -6.47 -0.34 3.49e-10 Intelligence (multi-trait analysis); CRC cis rs9322193 0.886 rs10872652 chr6:150096439 C/T cg13206674 chr6:150067644 NUP43 0.57 8.14 0.41 8.29e-15 Lung cancer; CRC cis rs4909189 1.000 rs12698214 chr7:158136204 T/G cg23298862 chr7:158159286 PTPRN2 0.49 7.03 0.36 1.17e-11 Response to amphetamines; CRC cis rs7119 0.604 rs2271396 chr15:77907535 C/G cg27398640 chr15:77910606 LINGO1 0.4 7.65 0.39 2.21e-13 Type 2 diabetes; CRC cis rs17818399 0.633 rs2242033 chr2:46842410 A/G cg26688816 chr2:46740690 ATP6V1E2 -0.47 -7.08 -0.36 8.76e-12 Height; CRC cis rs2735413 0.875 rs8053987 chr16:78084834 G/A cg04733911 chr16:78082701 NA 0.44 7.37 0.38 1.4e-12 Systolic blood pressure (alcohol consumption interaction); CRC cis rs7692995 1.000 rs16896215 chr4:17995312 T/C cg08925142 chr4:18023851 LCORL -0.52 -5.65 -0.3 3.45e-8 Height; CRC cis rs34034915 1 rs34034915 chr6:27720703 T/TG cg12273811 chr6:28175739 NA 0.45 6.51 0.34 2.86e-10 Hepatitis A; CRC trans rs11098499 0.954 rs12505469 chr4:120249585 C/T cg25214090 chr10:38739885 LOC399744 0.61 9.51 0.46 4.3e-19 Corneal astigmatism; CRC trans rs2014572 1.000 rs2014572 chr19:57760018 G/A cg02674126 chr19:40336878 FBL 0.42 6.69 0.35 9.82e-11 Hyperactive-impulsive symptoms; CRC trans rs1814175 0.817 rs11040651 chr11:49938395 G/A cg21153622 chr11:89784906 NA -0.38 -6.05 -0.32 3.99e-9 Height; CRC cis rs826838 1.000 rs1843881 chr12:38733706 A/G cg13010199 chr12:38710504 ALG10B -0.47 -6.18 -0.32 1.92e-9 Heart rate; CRC cis rs9393777 0.513 rs34388707 chr6:27050396 A/G cg12292205 chr6:26970375 C6orf41 -0.77 -8.45 -0.42 9.35e-16 Intelligence (multi-trait analysis); CRC cis rs769267 0.930 rs7256149 chr19:19566255 T/C cg02546618 chr19:19431379 KIAA0892;SF4 0.46 6.38 0.33 6.09e-10 Tonsillectomy; CRC cis rs734999 0.572 rs2985857 chr1:2532624 C/T cg18854424 chr1:2615690 NA -0.42 -8.07 -0.41 1.3e-14 Ulcerative colitis; CRC trans rs35110281 0.633 rs4818860 chr21:45119617 C/T cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.4 6.41 0.33 5.03e-10 Mean corpuscular volume; CRC trans rs7726839 0.574 rs11739866 chr5:636299 C/T cg25482853 chr8:67687455 SGK3 1.11 12.99 0.58 2.06e-31 Obesity-related traits; CRC cis rs2832191 0.791 rs28633762 chr21:30500070 C/T cg24692254 chr21:30365293 RNF160 -0.67 -11.39 -0.53 1.41e-25 Dental caries; CRC cis rs34375054 0.573 rs12579211 chr12:125647752 C/T cg06287003 chr12:125626642 AACS -0.62 -7.12 -0.37 6.71e-12 Post bronchodilator FEV1/FVC ratio; CRC cis rs13108904 0.905 rs1680074 chr4:1279621 G/A cg23123621 chr4:1343375 KIAA1530 -0.37 -6.9 -0.36 2.68e-11 Obesity-related traits; CRC cis rs10771431 0.597 rs7976807 chr12:9352459 G/A cg22349387 chr12:9600060 DDX12 -0.37 -5.71 -0.3 2.57e-8 Breast size; CRC cis rs6479527 0.875 rs2150625 chr9:96789831 C/T cg14459158 chr9:96720562 NA 0.36 6.41 0.33 5.01e-10 Esophageal adenocarcinoma; CRC cis rs2477686 0.526 rs1998760 chr1:2397136 C/T cg02850689 chr1:2391347 NA -0.44 -6.83 -0.35 4.08e-11 Non-obstructive azoospermia; CRC cis rs2832191 0.967 rs3787660 chr21:30520907 C/T cg24692254 chr21:30365293 RNF160 0.6 10.41 0.5 3.89e-22 Dental caries; CRC cis rs116095464 0.558 rs10055405 chr5:265666 C/T cg22496380 chr5:211416 CCDC127 -0.92 -10.51 -0.5 1.77e-22 Breast cancer; CRC cis rs2243480 1.000 rs778704 chr7:65863467 T/C cg18252515 chr7:66147081 NA -1.3 -15.32 -0.65 2.37e-40 Diabetic kidney disease; CRC cis rs6500602 0.727 rs4786510 chr16:4571247 A/G cg08645402 chr16:4508243 NA 0.64 11.31 0.53 2.78e-25 Schizophrenia; CRC cis rs9549367 0.789 rs7994324 chr13:113906497 T/C cg18105134 chr13:113819100 PROZ -0.74 -10.54 -0.5 1.38e-22 Platelet distribution width; CRC cis rs9486715 1.000 rs3798297 chr6:97062835 C/T cg18709589 chr6:96969512 KIAA0776 -0.54 -7.82 -0.4 7.38e-14 Headache; CRC cis rs6860806 0.631 rs4705931 chr5:131588345 T/C cg11843238 chr5:131593191 PDLIM4 0.42 7.98 0.4 2.47e-14 Breast cancer; CRC cis rs853679 0.760 rs9295768 chr6:28209102 G/A cg02683197 chr6:28174875 NA 0.64 6.54 0.34 2.37e-10 Depression; CRC cis rs2249694 0.537 rs9418988 chr10:135327632 C/T cg20169779 chr10:135381914 SYCE1 0.64 10.1 0.49 4.69e-21 Obesity-related traits; CRC cis rs4478858 0.735 rs11582342 chr1:31810681 A/G cg00250761 chr1:31883323 NA -0.44 -8.5 -0.42 6.71e-16 Alcohol dependence; CRC cis rs875971 0.862 rs801195 chr7:66026115 A/G cg00343986 chr7:65444356 GUSB -0.45 -6.23 -0.33 1.39e-9 Aortic root size; CRC cis rs7772486 0.686 rs1415744 chr6:146022531 C/T cg23711669 chr6:146136114 FBXO30 0.64 10.77 0.51 2.33e-23 Lobe attachment (rater-scored or self-reported); CRC cis rs10751667 0.643 rs10751669 chr11:942344 C/G cg01483505 chr11:975446 AP2A2 -0.41 -6.5 -0.34 2.99e-10 Alzheimer's disease (late onset); CRC cis rs55665837 1.000 rs12364959 chr11:14507435 T/C cg19336497 chr11:14380999 RRAS2 -0.4 -6.68 -0.35 1.03e-10 Vitamin D levels; CRC cis rs9503598 0.644 rs7774747 chr6:3430996 A/G cg00476032 chr6:3446245 SLC22A23 -0.34 -5.69 -0.3 2.83e-8 Cognitive ability (multi-trait analysis);Cognitive ability;Intelligence (multi-trait analysis); CRC cis rs926938 0.527 rs360583 chr1:115462743 C/T cg12756093 chr1:115239321 AMPD1 0.48 7.0 0.36 1.43e-11 Autism; CRC cis rs9847710 0.933 rs1529544 chr3:53039455 A/G cg04503182 chr3:53078218 SFMBT1 -0.41 -6.48 -0.34 3.41e-10 Ulcerative colitis; CRC cis rs6741819 0.740 rs771265 chr2:7129744 A/G cg27144453 chr2:7172511 RNF144A -0.4 -5.89 -0.31 9.75e-9 Response to antipsychotic treatment; CRC cis rs2721195 0.967 rs1985022 chr8:145684031 C/T cg15320075 chr8:145703422 NA 0.65 10.21 0.49 1.98e-21 Age at first birth; CRC cis rs4423214 1.000 rs7935125 chr11:71184190 C/A cg05163923 chr11:71159392 DHCR7 0.66 9.34 0.46 1.47e-18 Vitamin D levels; CRC cis rs798554 0.797 rs798494 chr7:2798294 C/A cg04166393 chr7:2884313 GNA12 0.48 6.44 0.33 4.3e-10 Height; CRC cis rs4665809 0.941 rs6735145 chr2:26270302 T/C cg27170947 chr2:26402098 FAM59B -0.44 -5.91 -0.31 8.44e-9 Gut microbiome composition (summer); CRC cis rs7552404 0.696 rs10782602 chr1:76464261 T/C cg03433033 chr1:76189801 ACADM 0.68 7.88 0.4 4.77e-14 Blood metabolite levels;Acylcarnitine levels; CRC cis rs79839061 0.656 rs11726508 chr4:888937 C/T cg14530993 chr4:882597 GAK 0.63 6.47 0.34 3.52e-10 Intelligence (multi-trait analysis); CRC trans rs1973993 0.967 rs10489741 chr1:96942406 G/A cg10631902 chr5:14652156 NA 0.51 9.1 0.45 8.54e-18 Weight; CRC cis rs853679 0.517 rs4713148 chr6:28115921 G/A cg15845792 chr6:28175446 NA 1.04 13.89 0.61 7.67e-35 Depression; CRC cis rs863345 0.564 rs1418844 chr1:158457569 A/T cg12129480 chr1:158549410 OR10X1 -0.29 -6.04 -0.32 4.2e-9 Pneumococcal bacteremia; CRC cis rs873946 0.504 rs12254034 chr10:134571007 T/C cg27286337 chr10:134555280 INPP5A 0.67 8.8 0.44 7.99e-17 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CRC cis rs3793683 0.520 rs12769959 chr10:134579026 A/C cg26818010 chr10:134567672 INPP5A -0.61 -8.13 -0.41 9e-15 Migraine; CRC cis rs919433 0.929 rs1366836 chr2:198172148 T/G cg20885578 chr2:198174922 NA -0.41 -7.35 -0.38 1.61e-12 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC cis rs2303745 0.544 rs6512180 chr19:17399153 C/T cg15110403 chr19:17392923 ANKLE1 -0.36 -5.73 -0.3 2.23e-8 Systemic lupus erythematosus; CRC cis rs4731207 0.698 rs6949341 chr7:124564176 C/A cg23710748 chr7:124431027 NA -0.37 -5.99 -0.31 5.5e-9 Cutaneous malignant melanoma; CRC cis rs17767392 0.813 rs66645707 chr14:71985931 T/C cg13720639 chr14:72061746 SIPA1L1 -0.49 -6.4 -0.33 5.28e-10 Mitral valve prolapse; CRC cis rs453301 0.686 rs3895823 chr8:8873646 T/C cg06636001 chr8:8085503 FLJ10661 -0.49 -7.37 -0.38 1.42e-12 Joint mobility (Beighton score); CRC cis rs919433 0.963 rs12693815 chr2:198168403 T/C cg03934865 chr2:198174659 NA -0.45 -7.08 -0.36 8.71e-12 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC cis rs10504229 0.773 rs1874373 chr8:58194423 T/C cg24829409 chr8:58192753 C8orf71 -0.62 -10.3 -0.49 9.29e-22 Developmental language disorder (linguistic errors); CRC cis rs4665809 1.000 rs4665811 chr2:26260017 A/G cg25036284 chr2:26402008 FAM59B -0.46 -5.94 -0.31 7.13e-9 Gut microbiome composition (summer); CRC cis rs17666538 0.585 rs1669733 chr8:606696 C/T cg07685180 chr8:600429 NA -0.73 -7.08 -0.36 8.74e-12 IgG glycosylation; CRC cis rs9660180 1.000 rs9660180 chr1:1723031 G/A cg03396347 chr1:1875803 NA -0.6 -9.38 -0.46 1.15e-18 Body mass index; CRC cis rs9372498 0.505 rs17080456 chr6:118985938 G/C cg01339444 chr6:118972232 C6orf204 0.54 5.96 0.31 6.41e-9 Diastolic blood pressure; CRC cis rs2991971 1.000 rs667626 chr1:46020551 T/C cg24296786 chr1:45957014 TESK2 0.49 7.0 0.36 1.42e-11 High light scatter reticulocyte count; CRC cis rs6461049 0.519 rs3778992 chr7:2175313 C/G cg04267008 chr7:1944627 MAD1L1 -0.57 -8.74 -0.43 1.19e-16 Schizophrenia; CRC cis rs9467773 1.000 rs9467773 chr6:26498426 A/G cg09904177 chr6:26538194 HMGN4 0.85 14.65 0.63 9.4e-38 Intelligence (multi-trait analysis); CRC trans rs7615952 0.543 rs4645102 chr3:125424441 A/G cg08546805 chr12:8549446 NA -0.41 -6.27 -0.33 1.15e-9 Blood pressure (smoking interaction); CRC cis rs875971 1.000 rs10257427 chr7:65743208 T/C cg12463550 chr7:65579703 CRCP -0.48 -6.86 -0.35 3.42e-11 Aortic root size; CRC cis rs2932538 0.922 rs7522110 chr1:113072914 A/C cg22162597 chr1:113214053 CAPZA1 0.7 9.85 0.48 3.23e-20 Systolic blood pressure;Diastolic blood pressure;Hypertension;Blood pressure; CRC cis rs473651 0.935 rs474478 chr2:239335473 C/T cg08773314 chr2:239334832 ASB1 0.38 8.81 0.44 7.54e-17 Multiple system atrophy; CRC cis rs13191362 1.000 rs35092540 chr6:163090778 A/G cg21926612 chr6:163149169 PACRG;PARK2 0.97 12.48 0.57 1.63e-29 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs736408 0.609 rs1029871 chr3:52797634 G/C cg08222913 chr3:52553049 STAB1 -0.33 -5.99 -0.31 5.57e-9 Bipolar disorder; CRC cis rs1707322 0.752 rs4607935 chr1:46117161 C/T cg03146154 chr1:46216737 IPP 0.66 9.64 0.47 1.55e-19 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs7727544 0.507 rs9791170 chr5:131569627 A/G cg27615366 chr5:131592974 PDLIM4 0.35 6.67 0.35 1.1e-10 Blood metabolite levels; CRC trans rs11098499 0.820 rs13128602 chr4:120459366 C/T cg25214090 chr10:38739885 LOC399744 -0.66 -10.55 -0.5 1.28e-22 Corneal astigmatism; CRC cis rs2243480 1.000 rs313814 chr7:65503293 C/A cg25985355 chr7:65971099 NA -0.54 -6.14 -0.32 2.35e-9 Diabetic kidney disease; CRC cis rs6762 0.692 rs5030778 chr11:836008 T/C cg15787769 chr11:842744 TSPAN4;POLR2L -0.47 -6.64 -0.34 1.3100000000000001e-10 Mean platelet volume; CRC cis rs728616 0.681 rs3862518 chr10:81917957 A/G cg11900509 chr10:81946545 ANXA11 -0.71 -8.58 -0.43 3.71e-16 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs56979318 1 rs56979318 chr17:80522718 A/T cg10255544 chr17:80519551 FOXK2 0.36 5.65 0.3 3.5e-8 Reticulocyte count; CRC cis rs10504229 0.953 rs6990806 chr8:58183113 G/A cg02290350 chr8:58132656 NA -0.42 -5.96 -0.31 6.62e-9 Developmental language disorder (linguistic errors); CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg26172385 chr10:120840446 EIF3A 0.47 6.51 0.34 2.87e-10 Anxiety disorder; CRC cis rs6076065 0.723 rs2252824 chr20:23354748 C/T cg11657817 chr20:23433608 CST11 0.44 6.37 0.33 6.43e-10 Facial morphology (factor 15, philtrum width); CRC cis rs875971 0.929 rs34406470 chr7:65929956 A/G cg12463550 chr7:65579703 CRCP 0.47 6.72 0.35 7.96e-11 Aortic root size; CRC cis rs875971 0.505 rs1723275 chr7:65504633 G/C cg00343986 chr7:65444356 GUSB -0.58 -8.72 -0.43 1.38e-16 Aortic root size; CRC cis rs7089973 0.604 rs7895830 chr10:116625776 A/G cg23260525 chr10:116636907 FAM160B1 0.39 9.19 0.45 4.49e-18 Bipolar disorder or attention deficit hyperactivity disorder; CRC cis rs300703 0.719 rs437853 chr2:196973 C/T cg21211680 chr2:198530 NA -0.89 -11.58 -0.54 3.16e-26 Blood protein levels; CRC cis rs3751196 0.711 rs75479531 chr12:104226138 T/G cg02344784 chr12:104178138 NT5DC3 0.7 7.16 0.37 5.32e-12 Sense of smell; CRC cis rs3749237 1.000 rs6804655 chr3:49738945 C/T cg05072774 chr3:49840536 C3orf54 -0.43 -5.68 -0.3 3e-8 Resting heart rate; CRC cis rs3026101 0.671 rs56113612 chr17:5297761 A/G cg25236894 chr17:5323110 RPAIN;NUP88 0.42 6.79 0.35 5.16e-11 Body mass index; CRC cis rs9914988 0.887 rs12451790 chr17:27112000 C/G cg20469991 chr17:27169893 C17orf63 -0.6 -7.27 -0.37 2.59e-12 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs11148252 0.538 rs2296349 chr13:52710058 T/G cg02158880 chr13:53174818 NA 0.39 5.64 0.3 3.76e-8 Lewy body disease; CRC cis rs10486722 0.606 rs10951662 chr7:41811635 C/G cg22138096 chr7:41772439 LOC285954 0.45 5.75 0.3 2.09e-8 Pit-and-Fissure caries; CRC cis rs1448094 0.511 rs11117023 chr12:86145329 G/A cg19622623 chr12:86230825 RASSF9 0.4 6.15 0.32 2.22e-9 Major depressive disorder; CRC cis rs116095464 0.558 rs10475136 chr5:232796 A/G cg22496380 chr5:211416 CCDC127 -0.91 -10.48 -0.5 2.21e-22 Breast cancer; CRC cis rs739401 0.611 rs10833048 chr11:3020040 A/G cg25174290 chr11:3078921 CARS 0.47 7.28 0.37 2.45e-12 Longevity; CRC cis rs6694672 0.510 rs1412638 chr1:196995638 T/C cg13682187 chr1:196946512 CFHR5 0.49 7.59 0.39 3.32e-13 Asthma; CRC cis rs3892630 0.824 rs35700505 chr19:33325006 C/T cg22980127 chr19:33182716 NUDT19 0.91 11.03 0.52 2.68e-24 Red blood cell traits; CRC cis rs8062405 0.824 rs4788083 chr16:28545449 A/G cg05139728 chr16:28306816 SBK1 -0.34 -5.79 -0.3 1.6e-8 Cognitive ability (multi-trait analysis);Cognitive ability; CRC cis rs1865760 0.516 rs9379818 chr6:26023206 G/T cg18357526 chr6:26021779 HIST1H4A 0.43 6.14 0.32 2.41e-9 Height; CRC cis rs9818941 1.000 rs4507209 chr3:157710946 T/A cg08654915 chr3:157813417 NA -0.32 -5.94 -0.31 7.14e-9 Height; CRC cis rs7552404 0.727 rs11161626 chr1:76260837 C/T cg10523679 chr1:76189770 ACADM 0.68 8.68 0.43 1.89e-16 Blood metabolite levels;Acylcarnitine levels; CRC cis rs4481887 0.927 rs4564179 chr1:248472422 T/C cg00666640 chr1:248458726 OR2T12 0.45 7.8 0.4 8.31e-14 Common traits (Other); CRC cis rs13108904 0.901 rs12509700 chr4:1296321 A/G cg20887711 chr4:1340912 KIAA1530 0.44 6.47 0.34 3.5e-10 Obesity-related traits; CRC cis rs17270561 0.609 rs9358873 chr6:25731783 C/T cg17691542 chr6:26056736 HIST1H1C 0.74 9.27 0.45 2.6e-18 Iron status biomarkers; CRC cis rs1448094 0.556 rs61930626 chr12:86167445 A/G cg02569458 chr12:86230093 RASSF9 0.48 8.02 0.4 1.9e-14 Major depressive disorder; CRC cis rs4588572 0.643 rs10063742 chr5:77759362 A/G cg11547950 chr5:77652471 NA -0.53 -7.17 -0.37 4.9e-12 Triglycerides; CRC cis rs12142240 0.660 rs72890715 chr1:46852077 A/G cg14993813 chr1:46806288 NSUN4 -0.48 -6.03 -0.32 4.47e-9 Menopause (age at onset); CRC cis rs7811142 1.000 rs7811142 chr7:100065443 A/T cg00814883 chr7:100076585 TSC22D4 -0.75 -9.44 -0.46 6.97e-19 Platelet count; CRC cis rs1448094 0.511 rs58742237 chr12:86166444 C/T cg25456477 chr12:86230367 RASSF9 0.37 6.16 0.32 2.13e-9 Major depressive disorder; CRC cis rs2235642 0.717 rs2236269 chr16:1652614 T/A cg26528668 chr16:1614120 IFT140 0.36 5.61 0.3 4.41e-8 Coronary artery disease; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg26365399 chr6:127587909 RNF146 0.35 6.06 0.32 3.83e-9 Liver disease severity in Alagille syndrome; CRC cis rs4713675 0.565 rs4713671 chr6:33699899 A/G cg14003231 chr6:33640908 ITPR3 0.44 7.17 0.37 4.85e-12 Plateletcrit; CRC cis rs6951245 0.554 rs76243429 chr7:1152543 C/T cg20603222 chr7:1096387 C7orf50;GPR146 -0.44 -5.71 -0.3 2.49e-8 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs9926296 0.512 rs11076626 chr16:89865103 T/A cg03388025 chr16:89894329 SPIRE2 0.44 9.05 0.45 1.27e-17 Vitiligo; CRC cis rs10504229 0.728 rs17215676 chr8:58152915 G/T cg08219700 chr8:58056026 NA 0.45 5.74 0.3 2.11e-8 Developmental language disorder (linguistic errors); CRC cis rs13108904 0.875 rs1732099 chr4:1282696 T/C cg05665937 chr4:1216051 CTBP1 -0.37 -5.75 -0.3 1.99e-8 Obesity-related traits; CRC cis rs2252521 0.583 rs317707 chr7:29098336 G/T cg11728747 chr7:29037910 CPVL -0.47 -6.85 -0.35 3.63e-11 Cognitive performance; CRC cis rs9322193 0.924 rs9322189 chr6:149909933 T/C cg13206674 chr6:150067644 NUP43 0.67 9.79 0.48 4.92e-20 Lung cancer; CRC trans rs11098499 0.863 rs6853998 chr4:120475860 C/A cg25214090 chr10:38739885 LOC399744 0.66 10.41 0.5 4.04e-22 Corneal astigmatism; CRC cis rs8077889 1.000 rs17675122 chr17:41886190 A/G cg25876840 chr17:41920477 NA 0.57 7.89 0.4 4.48e-14 Triglycerides; CRC cis rs2882667 0.931 rs10075951 chr5:138355963 G/T cg09476006 chr5:138032270 NA 0.43 7.13 0.37 6.58e-12 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs10946940 0.965 rs6910838 chr6:27515519 A/C cg02683197 chr6:28174875 NA -0.54 -7.4 -0.38 1.15e-12 Systemic lupus erythematosus; CRC cis rs889312 0.500 rs33323 chr5:56175566 C/G cg24531977 chr5:56204891 C5orf35 -0.47 -7.17 -0.37 4.99e-12 Breast cancer;Breast cancer (early onset); CRC cis rs2576037 0.583 rs8098948 chr18:44512332 C/A cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.56 -8.38 -0.42 1.58e-15 Personality dimensions; CRC cis rs1218582 0.772 rs6669791 chr1:154845484 G/T cg24250549 chr1:154909240 PMVK 0.63 10.68 0.51 4.49e-23 Prostate cancer; CRC cis rs601339 1.000 rs601339 chr12:123174743 A/G cg25190513 chr12:123201362 GPR109B -0.5 -6.32 -0.33 8.41e-10 Adiponectin levels; CRC trans rs35110281 0.837 rs12627667 chr21:45071396 A/C cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.42 6.8 0.35 5.03e-11 Mean corpuscular volume; CRC cis rs9300255 0.664 rs12316131 chr12:123817796 T/C cg00376283 chr12:123451042 ABCB9 -0.55 -7.22 -0.37 3.54e-12 Neutrophil percentage of white cells; CRC cis rs2721195 0.967 rs1985022 chr8:145684031 C/T cg17328964 chr8:145687451 CYHR1 -0.76 -13.63 -0.6 7.68e-34 Age at first birth; CRC cis rs243505 0.660 rs3779037 chr7:148539323 T/C cg09806900 chr7:148480153 CUL1 0.52 6.63 0.34 1.38e-10 Inflammatory bowel disease;Crohn's disease; CRC cis rs7666738 0.830 rs4699580 chr4:98930673 T/C cg05340658 chr4:99064831 C4orf37 0.6 9.35 0.46 1.41e-18 Colonoscopy-negative controls vs population controls; CRC cis rs6495122 0.618 rs4886413 chr15:75262310 G/C cg14664628 chr15:75095509 CSK -0.53 -7.61 -0.39 2.87e-13 Caffeine consumption;Diastolic blood pressure;Coffee consumption; CRC trans rs916888 0.773 rs199534 chr17:44824213 T/G cg22968622 chr17:43663579 NA 1.48 18.84 0.72 3.21e-54 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs8180040 0.764 rs13061071 chr3:47138708 G/A cg10298567 chr3:47292165 KIF9 -0.37 -6.01 -0.31 4.79e-9 Colorectal cancer; CRC cis rs9443645 0.901 rs1538235 chr6:79689450 C/T cg11833968 chr6:79620685 NA -0.36 -6.15 -0.32 2.24e-9 Intelligence (multi-trait analysis); CRC cis rs6582630 0.638 rs10880644 chr12:38554959 G/A cg26384229 chr12:38710491 ALG10B 0.41 5.98 0.31 5.89e-9 Drug-induced liver injury (flucloxacillin); CRC cis rs17253792 0.822 rs17832365 chr14:56153531 C/G cg01858014 chr14:56050164 KTN1 -0.85 -6.84 -0.35 3.89e-11 Putamen volume; CRC cis rs7113874 0.569 rs10769914 chr11:8576202 A/G cg02811074 chr11:8615871 STK33 -0.34 -5.85 -0.31 1.21e-8 Body mass index in physically active individuals;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs863345 0.604 rs12123305 chr1:158498955 G/A cg12129480 chr1:158549410 OR10X1 -0.3 -6.27 -0.33 1.12e-9 Pneumococcal bacteremia; CRC cis rs7725052 0.581 rs5022489 chr5:40457784 T/A cg09067459 chr5:40385259 NA -0.4 -6.58 -0.34 1.86e-10 Pediatric autoimmune diseases; CRC cis rs7552404 0.924 rs1611823 chr1:76221706 T/G cg22875332 chr1:76189707 ACADM 0.69 10.56 0.5 1.2e-22 Blood metabolite levels;Acylcarnitine levels; CRC cis rs7173743 0.784 rs11072810 chr15:79132206 C/T cg15571903 chr15:79123663 NA -0.32 -5.9 -0.31 9.06e-9 Coronary artery disease; CRC cis rs6076065 0.722 rs6048760 chr20:23345844 G/T cg11657817 chr20:23433608 CST11 -0.48 -8.12 -0.41 9.7e-15 Facial morphology (factor 15, philtrum width); CRC cis rs4665809 1.000 rs3910272 chr2:26287842 T/A cg26119090 chr2:26468346 HADHA;HADHB -0.67 -8.27 -0.41 3.39e-15 Gut microbiome composition (summer); CRC cis rs6831352 0.918 rs34805407 chr4:100050786 C/A cg13256891 chr4:100009986 ADH5 -0.66 -8.89 -0.44 4.04e-17 Alcohol dependence; CRC trans rs7618501 0.722 rs9853458 chr3:49783211 A/C cg21582582 chr3:182698605 DCUN1D1 -0.56 -8.34 -0.42 2.08e-15 Intelligence (multi-trait analysis); CRC cis rs798554 0.797 rs798493 chr7:2798731 A/G cg19346786 chr7:2764209 NA -0.43 -7.4 -0.38 1.14e-12 Height; CRC cis rs10751667 0.666 rs7396677 chr11:958878 C/T cg23136738 chr11:925521 AP2A2 -0.42 -7.2 -0.37 4.09e-12 Alzheimer's disease (late onset); CRC cis rs6908034 0.607 rs76525593 chr6:19809170 G/T cg02682789 chr6:19804855 NA 0.79 6.58 0.34 1.81e-10 Endometriosis;Deep ovarian and/or rectovaginal disease with dense adhesions; CRC cis rs9325144 0.555 rs4882358 chr12:38726640 A/G cg26384229 chr12:38710491 ALG10B 0.53 7.95 0.4 3.02e-14 Morning vs. evening chronotype; CRC cis rs4713118 0.513 rs149955 chr6:28036225 G/C cg21251018 chr6:28226885 NKAPL 0.47 7.15 0.37 5.64e-12 Parkinson's disease; CRC cis rs12142240 0.698 rs932816 chr1:46859749 G/A cg00530320 chr1:46809349 NSUN4 0.59 8.07 0.41 1.35e-14 Menopause (age at onset); CRC cis rs2576037 0.544 rs629097 chr18:44378097 T/C cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.64 11.11 0.52 1.51e-24 Personality dimensions; CRC cis rs116095464 0.558 rs10079760 chr5:230778 A/G cg22857025 chr5:266934 NA -1.09 -14.69 -0.63 6.73e-38 Breast cancer; CRC cis rs66887589 0.934 rs56843000 chr4:120516597 T/C cg09307838 chr4:120376055 NA -0.51 -7.77 -0.39 1.02e-13 Diastolic blood pressure; CRC cis rs995000 0.965 rs10789112 chr1:62957758 T/C cg19896129 chr1:63156450 NA 0.4 5.83 0.31 1.33e-8 Triglyceride levels; CRC cis rs10463316 0.894 rs7718085 chr5:150742957 G/C cg03212797 chr5:150827313 SLC36A1 -0.5 -7.6 -0.39 3.12e-13 Metabolite levels (Pyroglutamine); CRC cis rs7666738 0.800 rs12163918 chr4:98835794 T/C cg17366294 chr4:99064904 C4orf37 0.42 6.65 0.34 1.19e-10 Colonoscopy-negative controls vs population controls; CRC cis rs863345 0.564 rs4614256 chr1:158464611 T/G cg12129480 chr1:158549410 OR10X1 -0.3 -6.29 -0.33 9.9e-10 Pneumococcal bacteremia; CRC cis rs9322193 0.962 rs7818 chr6:150132092 A/G cg13206674 chr6:150067644 NUP43 0.59 8.5 0.42 6.54e-16 Lung cancer; CRC cis rs9611565 0.649 rs79005 chr22:41835544 G/A cg06481639 chr22:41940642 POLR3H 0.5 6.17 0.32 1.99e-9 Vitiligo; CRC cis rs7119 0.700 rs60701760 chr15:77888152 G/A cg27398640 chr15:77910606 LINGO1 0.41 7.79 0.39 9.13e-14 Type 2 diabetes; CRC cis rs1971762 0.563 rs10747679 chr12:54077750 C/T cg06632207 chr12:54070931 ATP5G2 0.41 7.06 0.36 9.73e-12 Height; CRC cis rs12497850 0.931 rs4072859 chr3:49032205 G/C cg20833759 chr3:49053208 WDR6;DALRD3 0.54 9.39 0.46 1.06e-18 Parkinson's disease; CRC cis rs2976388 1.000 rs2976396 chr8:143764001 A/G cg04969067 chr8:143858791 LYNX1 0.36 6.16 0.32 2.15e-9 Urinary tract infection frequency; CRC trans rs7395662 1.000 rs11039817 chr11:48561480 A/T cg21153622 chr11:89784906 NA -0.44 -7.11 -0.36 7.07e-12 HDL cholesterol; CRC cis rs2235544 0.579 rs1537321 chr1:54482236 C/A cg25741118 chr1:54482237 LDLRAD1 -0.21 -5.91 -0.31 8.48e-9 Multiple myeloma (hyperdiploidy);Thyroid hormone levels; CRC trans rs7395662 0.816 rs11039764 chr11:48484616 T/C cg21153622 chr11:89784906 NA -0.5 -8.01 -0.4 1.95e-14 HDL cholesterol; CRC cis rs72781680 1.000 rs12623496 chr2:24181583 C/T cg08917208 chr2:24149416 ATAD2B 0.9 9.17 0.45 5.14e-18 Lymphocyte counts; CRC trans rs629535 0.814 rs549643 chr8:70062884 C/T cg21567404 chr3:27674614 NA 0.88 14.38 0.62 9.75e-37 Dupuytren's disease; CRC cis rs17253792 0.545 rs3742570 chr14:56016434 A/C cg01858014 chr14:56050164 KTN1 -0.89 -6.84 -0.35 3.84e-11 Putamen volume; CRC cis rs9788333 0.962 rs61951450 chr13:21886354 G/A cg25811766 chr13:21894605 NA 0.61 9.06 0.45 1.18e-17 Thiazide-induced adverse metabolic effects in hypertensive patients; CRC trans rs4650994 1.000 rs10798616 chr1:178515642 G/C cg05059571 chr16:84539110 KIAA1609 -0.48 -7.34 -0.38 1.63e-12 HDL cholesterol levels;HDL cholesterol; CRC cis rs853679 1.000 rs853685 chr6:28288785 C/T cg15786705 chr6:28176104 NA 0.56 5.91 0.31 8.32e-9 Depression; CRC cis rs6502050 0.835 rs34867501 chr17:80121358 T/C cg13198984 chr17:80129470 CCDC57 0.47 8.35 0.42 1.88e-15 Life satisfaction; CRC cis rs1153858 1.000 rs7179743 chr15:45638331 G/C cg10760299 chr15:45669010 GATM 0.5 7.99 0.4 2.37e-14 Homoarginine levels; CRC cis rs2880765 0.835 rs4514633 chr15:86041017 T/G cg17133734 chr15:86042851 AKAP13 0.45 7.08 0.36 8.55e-12 Coronary artery disease; CRC cis rs853679 0.517 rs9393895 chr6:28127621 T/C cg25164649 chr6:28176230 NA 0.77 9.53 0.47 3.55e-19 Depression; CRC cis rs806795 0.605 rs6935954 chr6:26255451 A/G cg00631329 chr6:26305371 NA -0.55 -9.08 -0.45 1.02e-17 Mosquito bite size; CRC cis rs9463078 0.585 rs7757282 chr6:45302654 A/G cg25276700 chr6:44698697 NA 0.24 5.61 0.3 4.21e-8 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; CRC cis rs9549367 0.789 rs7317558 chr13:113893625 G/A cg00898013 chr13:113819073 PROZ -0.43 -6.29 -0.33 1.01e-9 Platelet distribution width; CRC cis rs13191362 1.000 rs73035012 chr6:162997279 G/A cg06582575 chr6:163149167 PACRG;PARK2 0.77 10.7 0.51 3.98e-23 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs13256369 1.000 rs10098234 chr8:8576692 G/A cg18904891 chr8:8559673 CLDN23 0.49 6.54 0.34 2.41e-10 Obesity-related traits; CRC cis rs7552404 1.000 rs441109 chr1:76120430 T/G cg10523679 chr1:76189770 ACADM -0.82 -11.24 -0.53 5.17e-25 Blood metabolite levels;Acylcarnitine levels; CRC cis rs10848704 1.000 rs10848704 chr12:2882544 A/G cg19995117 chr12:2880862 NA -0.43 -7.15 -0.37 5.57e-12 Quantitative traits; CRC cis rs2415984 0.622 rs61993305 chr14:46950955 C/T cg14871534 chr14:47121158 RPL10L -0.44 -6.31 -0.33 9.06e-10 Number of children ever born; CRC trans rs57221529 0.709 rs72707023 chr5:667620 G/A cg11887960 chr12:57824829 NA 0.7 7.46 0.38 7.78e-13 Lung disease severity in cystic fibrosis; CRC cis rs473651 0.904 rs472247 chr2:239362573 G/A cg08773314 chr2:239334832 ASB1 0.36 8.25 0.41 3.79e-15 Multiple system atrophy; CRC cis rs9467711 0.790 rs34158769 chr6:26336572 G/A cg12315302 chr6:26189340 HIST1H4D 0.94 6.71 0.35 8.3e-11 Autism spectrum disorder or schizophrenia; CRC cis rs972578 0.837 rs738387 chr22:43329819 A/G cg01576275 chr22:43409880 NA 0.4 6.46 0.34 3.8e-10 Mean platelet volume; CRC cis rs2839186 0.647 rs9976233 chr21:47616913 G/A cg12516959 chr21:47718080 NA 0.33 5.87 0.31 1.06e-8 Testicular germ cell tumor; CRC cis rs1003719 0.788 rs61701101 chr21:38450317 G/A cg10648535 chr21:38446584 PIGP;TTC3 0.53 7.53 0.38 4.9e-13 Eye color traits; CRC cis rs10504229 0.679 rs17801003 chr8:58050930 A/G cg02290350 chr8:58132656 NA -0.54 -6.4 -0.33 5.38e-10 Developmental language disorder (linguistic errors); CRC cis rs6969780 0.908 rs6461987 chr7:27166956 G/C cg26364809 chr7:27145159 NA -0.74 -6.6 -0.34 1.69e-10 Diastolic blood pressure;Blood pressure traits (multi-trait analysis);Systolic blood pressure;Hypertension; CRC cis rs9303401 0.659 rs35082010 chr17:56936867 A/G cg10487724 chr17:56770010 TEX14;RAD51C 0.76 9.53 0.47 3.57e-19 Cognitive test performance; CRC cis rs7618501 0.521 rs34654589 chr3:49911449 C/G cg24308560 chr3:49941425 MST1R -0.44 -6.61 -0.34 1.59e-10 Intelligence (multi-trait analysis); CRC cis rs6028335 0.502 rs6028235 chr20:37608550 A/G cg27552599 chr20:37590471 DHX35 0.37 5.81 0.3 1.49e-8 Alcohol and nicotine co-dependence; CRC cis rs977987 0.806 rs11640674 chr16:75394944 A/G cg03315344 chr16:75512273 CHST6 0.53 8.89 0.44 4.14e-17 Dupuytren's disease; CRC cis rs6693567 0.565 rs834235 chr1:150362154 C/T cg15654264 chr1:150340011 RPRD2 0.43 6.52 0.34 2.68e-10 Migraine; CRC cis rs7223966 1.000 rs8076717 chr17:61850301 C/T cg05941027 chr17:61774174 LIMD2 -0.35 -6.16 -0.32 2.1e-9 Hip circumference adjusted for BMI;Body mass index; CRC cis rs6089584 0.927 rs2296083 chr20:60574216 C/T cg23262073 chr20:60523788 NA -0.42 -7.3 -0.37 2.16e-12 Body mass index; CRC cis rs6076065 0.723 rs2424550 chr20:23394669 C/T cg11657817 chr20:23433608 CST11 0.43 6.33 0.33 8.11e-10 Facial morphology (factor 15, philtrum width); CRC cis rs7542091 0.748 rs2357231 chr1:210028454 A/C cg22029157 chr1:209979665 IRF6 -0.51 -8.13 -0.41 8.9e-15 Monobrow; CRC cis rs863345 0.625 rs11265006 chr1:158498485 C/G cg12129480 chr1:158549410 OR10X1 -0.3 -6.28 -0.33 1.09e-9 Pneumococcal bacteremia; CRC cis rs2832077 0.527 rs2776210 chr21:30268558 A/G cg08807101 chr21:30365312 RNF160 0.4 5.62 0.3 4.18e-8 Cognitive test performance; CRC cis rs6121246 0.909 rs8126355 chr20:30332660 C/T cg13852791 chr20:30311386 BCL2L1 0.67 10.95 0.52 5.48e-24 Mean corpuscular hemoglobin; CRC cis rs1218582 0.772 rs11264282 chr1:154867370 G/A cg06221963 chr1:154839813 KCNN3 -0.78 -15.75 -0.66 4.89e-42 Prostate cancer; CRC cis rs4665809 0.531 rs12990692 chr2:26464939 C/T cg22920501 chr2:26401640 FAM59B 0.85 12.62 0.57 4.71e-30 Gut microbiome composition (summer); CRC cis rs2836974 0.863 rs12483216 chr21:40539614 T/C cg11890956 chr21:40555474 PSMG1 1.08 19.02 0.72 5.97e-55 Cognitive function; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg09395034 chr5:137801102 EGR1 0.48 6.09 0.32 3.2e-9 Thyroid stimulating hormone; CRC cis rs6940729 1 rs6940729 chr6:47552920 T/A cg18841952 chr6:47652462 GPR111 0.33 5.82 0.31 1.43e-8 Plasma homocysteine levels; CRC trans rs11252926 0.931 rs12355162 chr10:563472 G/A cg00953403 chr17:74099816 EXOC7 -0.45 -6.07 -0.32 3.56e-9 Psychosis in Alzheimer's disease; CRC cis rs6456156 0.774 rs1556413 chr6:167524743 G/A cg05540913 chr6:167530185 CCR6 -0.35 -6.07 -0.32 3.58e-9 Primary biliary cholangitis; CRC cis rs1046896 0.512 rs3785513 chr17:80886748 G/A cg17346650 chr17:80929145 B3GNTL1 0.43 6.7 0.35 9.17e-11 Glycated hemoglobin levels; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg08830818 chr3:122514143 HSPBAP1;DIRC2 0.4 7.34 0.38 1.64e-12 Liver disease severity in Alagille syndrome; CRC cis rs4713118 0.662 rs149901 chr6:27965503 C/T cg15786705 chr6:28176104 NA 0.64 9.23 0.45 3.27e-18 Parkinson's disease; CRC cis rs6860806 0.507 rs635619 chr5:131720265 G/A cg09877947 chr5:131593287 PDLIM4 -0.44 -7.27 -0.37 2.67e-12 Breast cancer; CRC cis rs7429990 0.866 rs3732529 chr3:47970109 C/T cg11946769 chr3:48343235 NME6 0.45 5.92 0.31 8.17e-9 Educational attainment (years of education); CRC cis rs4332037 0.802 rs12113633 chr7:1932936 G/A cg23422044 chr7:1970798 MAD1L1 -0.61 -7.59 -0.39 3.32e-13 Bipolar disorder; CRC cis rs10540 1.000 rs35996687 chr11:458595 G/A cg03352830 chr11:487213 PTDSS2 0.67 7.15 0.37 5.61e-12 Body mass index; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg00295448 chr5:140044129 WDR55 0.47 6.93 0.36 2.27e-11 Intelligence (multi-trait analysis); CRC cis rs644799 1.000 rs680134 chr11:95559517 T/C cg25622487 chr11:95524042 FAM76B;CEP57 0.76 12.0 0.55 9.1e-28 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs9837602 1.000 rs704582 chr3:99571926 A/G cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G 0.47 5.73 0.3 2.22e-8 Breast cancer; CRC cis rs7605827 0.780 rs2287278 chr2:15667771 C/G cg19274914 chr2:15703543 NA 0.39 5.83 0.31 1.32e-8 Educational attainment (years of education); CRC cis rs1223397 0.938 rs34505804 chr6:13292514 G/A cg20827128 chr6:13274284 PHACTR1 0.56 6.56 0.34 2.05e-10 Blood pressure; CRC cis rs6964587 0.692 rs6970629 chr7:91846599 T/C cg17063962 chr7:91808500 NA 0.64 10.43 0.5 3.52e-22 Breast cancer; CRC cis rs763014 0.932 rs34498660 chr16:666149 A/G cg04497992 chr16:616212 NHLRC4 0.45 7.21 0.37 3.95e-12 Height; CRC trans rs57221529 0.766 rs72706606 chr5:558609 T/C cg25482853 chr8:67687455 SGK3 1.25 15.72 0.65 6.58e-42 Lung disease severity in cystic fibrosis; CRC cis rs9916302 0.861 rs10491129 chr17:37461643 T/G cg15445000 chr17:37608096 MED1 -0.41 -9.02 -0.45 1.54e-17 Glomerular filtration rate (creatinine); CRC cis rs6502050 0.835 rs10163485 chr17:80110750 C/T cg22110888 chr17:80059540 CCDC57 0.4 6.44 0.33 4.17e-10 Life satisfaction; CRC cis rs7809950 0.678 rs2237665 chr7:106906998 T/C cg23024343 chr7:107201750 COG5 -0.74 -10.23 -0.49 1.63e-21 Coronary artery disease; CRC cis rs7071206 0.891 rs10824559 chr10:79409222 A/G cg07817648 chr10:79422355 NA -0.73 -9.07 -0.45 1.11e-17 Bone mineral density; CRC cis rs6662572 1.000 rs7541935 chr1:46217493 C/T cg08644498 chr1:46502608 NA 0.45 6.73 0.35 7.5e-11 Blood protein levels; CRC cis rs7487075 0.797 rs10880959 chr12:46761127 G/A cg22049899 chr12:47219821 SLC38A4 0.32 5.99 0.31 5.43e-9 Itch intensity from mosquito bite; CRC cis rs9914988 0.943 rs12951232 chr17:27132638 G/C cg20469991 chr17:27169893 C17orf63 -0.6 -7.27 -0.37 2.59e-12 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs17376456 0.877 rs10060160 chr5:93387879 G/A cg21475434 chr5:93447410 FAM172A 0.74 7.58 0.39 3.47e-13 Diabetic retinopathy; CRC cis rs28386778 0.933 rs2665801 chr17:61952100 C/T cg11494091 chr17:61959527 GH2 0.61 10.44 0.5 3.2e-22 Prudent dietary pattern; CRC cis rs2257205 0.667 rs16943134 chr17:56681389 A/G cg25885038 chr17:56607967 SEPT4 -0.55 -5.99 -0.31 5.54e-9 Pancreatic cancer; CRC cis rs311392 0.902 rs681000 chr8:55094043 C/T cg20636351 chr8:55087400 NA -0.32 -5.7 -0.3 2.69e-8 Pelvic organ prolapse (moderate/severe); CRC cis rs853679 0.515 rs4580862 chr6:28367663 T/C cg21251018 chr6:28226885 NKAPL 0.39 5.81 0.31 1.48e-8 Depression; CRC cis rs769267 0.896 rs11882123 chr19:19386339 A/G cg03709012 chr19:19516395 GATAD2A 0.72 10.98 0.52 4.29e-24 Tonsillectomy; CRC cis rs2204008 0.720 rs11181343 chr12:38323616 G/T cg13010199 chr12:38710504 ALG10B 0.46 6.2 0.32 1.69e-9 Bladder cancer; CRC cis rs2457480 0.778 rs11238933 chr10:44714250 C/G cg09554077 chr10:44749378 NA 0.65 7.29 0.37 2.37e-12 Coronary artery disease; CRC cis rs12044355 0.964 rs12045144 chr1:231844248 T/C cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX 0.44 5.93 0.31 7.85e-9 Alzheimer's disease; CRC cis rs10905065 0.965 rs10737019 chr10:5783733 G/A cg25171089 chr10:5708825 ASB13 0.42 5.87 0.31 1.07e-8 Menopause (age at onset); CRC cis rs7618915 0.547 rs2590846 chr3:52692359 C/G cg18099408 chr3:52552593 STAB1 -0.44 -7.14 -0.37 6.2e-12 Bipolar disorder; CRC cis rs4638749 0.627 rs1522020 chr2:108833346 C/G cg25838818 chr2:108905173 SULT1C2 -0.34 -5.75 -0.3 2.01e-8 Blood pressure; CRC cis rs6500395 0.963 rs12444902 chr16:48667126 G/T cg04672837 chr16:48644449 N4BP1 0.43 6.51 0.34 2.85e-10 Response to tocilizumab in rheumatoid arthritis; CRC trans rs7395662 0.963 rs11039870 chr11:48626478 C/T cg21153622 chr11:89784906 NA -0.44 -7.09 -0.36 8.32e-12 HDL cholesterol; CRC cis rs2760061 0.626 rs634106 chr1:228121548 C/T cg18477163 chr1:228402036 OBSCN -0.35 -5.87 -0.31 1.07e-8 Diastolic blood pressure; CRC cis rs1552244 0.810 rs4019706 chr3:10112862 G/A cg16606324 chr3:10149918 C3orf24 0.7 9.64 0.47 1.61e-19 Alzheimer's disease; CRC cis rs12594515 1.000 rs8026221 chr15:45987910 G/T cg01629716 chr15:45996671 NA 0.41 8.46 0.42 9.03e-16 Waist circumference;Weight; CRC trans rs60843830 0.662 rs6721594 chr2:305203 C/T cg11347411 chr7:150020925 ACTR3C;LRRC61 -0.6 -9.19 -0.45 4.59e-18 Spherical equivalent (joint analysis main effects and education interaction); CRC trans rs2243480 0.803 rs160649 chr7:65543199 C/T cg10756647 chr7:56101905 PSPH 0.62 6.58 0.34 1.8e-10 Diabetic kidney disease; CRC cis rs5769707 0.967 rs9616327 chr22:50010891 G/A cg10356904 chr22:49881777 NA -0.32 -5.99 -0.31 5.44e-9 Monocyte count;Monocyte percentage of white cells; CRC cis rs2204008 0.540 rs3908193 chr12:38410907 G/T cg13010199 chr12:38710504 ALG10B -0.4 -5.65 -0.3 3.4e-8 Bladder cancer; CRC cis rs1178968 0.901 rs6949855 chr7:72728130 A/G cg25889504 chr7:72793014 NA 0.53 6.04 0.32 4.16e-9 Triglyceride levels; CRC cis rs2120019 1.000 rs34237279 chr15:75361121 A/G cg09165964 chr15:75287851 SCAMP5 -0.82 -13.01 -0.58 1.66e-31 Blood trace element (Zn levels); CRC trans rs7267979 0.933 rs2261109 chr20:25259200 T/C cg17903999 chr18:56338584 MALT1 -0.41 -6.76 -0.35 6.14e-11 Liver enzyme levels (alkaline phosphatase); CRC cis rs9911578 1.000 rs302854 chr17:56683612 G/A cg05425664 chr17:57184151 TRIM37 -0.51 -8.02 -0.4 1.9e-14 Intelligence (multi-trait analysis); CRC cis rs7385804 0.766 rs1734909 chr7:100309582 C/G cg20848291 chr7:100343083 ZAN 0.49 7.54 0.38 4.55e-13 Iron status biomarkers;Mean corpuscular hemoglobin;Hematocrit;Iron status biomarkers (transferrin saturation);Red blood cell count;Iron status biomarkers (iron levels);Mean corpuscular volume;Hematological parameters; CRC cis rs66569888 0.632 rs6728600 chr2:106898653 G/T cg15412446 chr2:106886593 NA -0.53 -7.61 -0.39 2.89e-13 Facial morphology (factor 23); CRC cis rs1552244 0.816 rs56271597 chr3:10042790 C/T cg02579736 chr3:10068473 FANCD2;CIDECP 0.96 12.39 0.56 3.4e-29 Alzheimer's disease; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg11543725 chr11:10329292 NA 0.4 6.75 0.35 6.66e-11 Liver disease severity in Alagille syndrome; CRC cis rs6496667 0.779 rs28516870 chr15:91037754 G/A cg04176472 chr15:90893244 GABARAPL3 0.53 7.77 0.39 9.86e-14 Rheumatoid arthritis; CRC cis rs2976388 0.647 rs2585154 chr8:143783485 C/T cg20041105 chr8:143859282 LYNX1 0.42 7.34 0.38 1.65e-12 Urinary tract infection frequency; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg27499259 chr13:28400924 NA 0.43 6.0 0.31 5.17e-9 Response to antipsychotic treatment; CRC cis rs17592366 0.517 rs11845027 chr14:35315574 A/G cg09327582 chr14:35236912 BAZ1A 0.49 6.89 0.36 2.82e-11 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells; CRC cis rs9640161 0.750 rs3735173 chr7:150020526 C/T cg12556325 chr7:150026731 C7orf29;LRRC61 -0.4 -6.16 -0.32 2.15e-9 Blood protein levels;Circulating chemerin levels; CRC cis rs546131 0.963 rs539044 chr11:34841542 G/T cg11058730 chr11:34937778 PDHX;APIP 0.5 7.31 0.37 2.06e-12 Lung disease severity in cystic fibrosis; CRC cis rs10504229 0.683 rs11781690 chr8:58132931 C/G cg04204079 chr8:58130323 NA -0.45 -5.78 -0.3 1.71e-8 Developmental language disorder (linguistic errors); CRC cis rs28386778 0.897 rs9913323 chr17:61851485 C/A cg07362569 chr17:61921086 SMARCD2 0.38 5.84 0.31 1.25e-8 Prudent dietary pattern; CRC cis rs17685 0.712 rs10235738 chr7:75773460 G/A cg16489192 chr7:75678113 MDH2;STYXL1 -0.36 -5.71 -0.3 2.56e-8 Coffee consumption;Coffee consumption (cups per day); CRC cis rs12142240 0.698 rs56909107 chr1:46808224 A/C cg00530320 chr1:46809349 NSUN4 0.58 7.98 0.4 2.46e-14 Menopause (age at onset); CRC cis rs9372498 0.536 rs9489452 chr6:118910868 G/C cg18833306 chr6:118973337 C6orf204 0.44 5.82 0.31 1.42e-8 Diastolic blood pressure; CRC cis rs921968 0.541 rs488767 chr2:219466860 G/T cg02176678 chr2:219576539 TTLL4 0.54 8.66 0.43 2.12e-16 Mean corpuscular hemoglobin concentration; CRC trans rs7267979 0.714 rs3787082 chr20:25235736 A/T cg17903999 chr18:56338584 MALT1 -0.42 -6.71 -0.35 8.62e-11 Liver enzyme levels (alkaline phosphatase); CRC cis rs11031096 0.678 rs2044135 chr11:4187233 G/A cg18678763 chr11:4115507 RRM1 -0.36 -5.82 -0.31 1.43e-8 Mean corpuscular volume;Mean corpuscular hemoglobin; CRC cis rs2996428 0.561 rs16824192 chr1:3748605 G/A cg17848003 chr1:3704513 LRRC47 0.41 6.04 0.32 4.27e-9 Red cell distribution width; CRC cis rs10504229 1.000 rs66870803 chr8:58180022 G/C cg02290350 chr8:58132656 NA -0.42 -5.96 -0.31 6.62e-9 Developmental language disorder (linguistic errors); CRC cis rs1707322 0.963 rs10890373 chr1:46393755 A/C cg03146154 chr1:46216737 IPP 0.56 7.75 0.39 1.14e-13 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs41005 0.967 rs41002 chr2:8113921 C/T cg03155496 chr2:8117019 LOC339788 0.41 7.25 0.37 2.96e-12 Response to anti-TNF therapy in rheumatoid arthritis; CRC cis rs10751667 1.000 rs11246359 chr11:967943 T/C ch.11.42038R chr11:967971 AP2A2 0.69 11.74 0.54 8.24e-27 Alzheimer's disease (late onset); CRC cis rs8180040 0.966 rs62260711 chr3:47564491 G/C cg02527881 chr3:46936655 PTH1R 0.37 6.75 0.35 6.76e-11 Colorectal cancer; CRC cis rs8072100 0.512 rs3809863 chr17:45385012 C/T cg25173405 chr17:45401733 C17orf57 -0.58 -9.76 -0.47 6.13e-20 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs4074961 0.669 rs6687545 chr1:38071195 C/T cg13401533 chr1:37979913 MEAF6 0.42 6.04 0.32 4.28e-9 Axial length; CRC cis rs10504229 0.679 rs17193048 chr8:58055392 G/A cg02290350 chr8:58132656 NA -0.6 -6.94 -0.36 2.16e-11 Developmental language disorder (linguistic errors); CRC cis rs1887596 0.639 rs581728 chr13:27202054 T/A cg01312412 chr13:27282625 NA 0.45 5.9 0.31 9.11e-9 Facial morphology (factor 3, length of philtrum); CRC cis rs35110281 0.807 rs1598206 chr21:45058776 A/G cg01579765 chr21:45077557 HSF2BP -0.35 -6.66 -0.34 1.18e-10 Mean corpuscular volume; CRC cis rs4481887 0.927 rs4345830 chr1:248474845 G/C cg00666640 chr1:248458726 OR2T12 0.45 7.8 0.4 8.31e-14 Common traits (Other); CRC cis rs4713118 0.955 rs9468203 chr6:27688667 A/G cg06470822 chr6:28175283 NA 0.64 8.49 0.42 6.99e-16 Parkinson's disease; CRC cis rs3771570 1.000 rs62193256 chr2:242362168 C/T cg21155796 chr2:242212141 HDLBP 0.65 6.98 0.36 1.67e-11 Prostate cancer; CRC cis rs10751667 0.666 rs7395267 chr11:962326 C/A cg06064525 chr11:970664 AP2A2 -0.3 -6.11 -0.32 2.78e-9 Alzheimer's disease (late onset); CRC cis rs13266463 1.000 rs13266463 chr8:143403693 A/G cg24996280 chr8:143481281 TSNARE1 -0.33 -5.76 -0.3 1.95e-8 Schizophrenia; CRC cis rs10992471 0.756 rs2516568 chr9:95187380 A/T cg14631576 chr9:95140430 CENPP -0.4 -7.4 -0.38 1.13e-12 Visceral adipose tissue/subcutaneous adipose tissue ratio; CRC trans rs11039798 0.512 rs3974936 chr11:49005012 C/T cg15704280 chr7:45808275 SEPT13 0.63 6.46 0.34 3.82e-10 Axial length; CRC cis rs4474465 0.573 rs7101478 chr11:78272517 C/A cg27205649 chr11:78285834 NARS2 0.5 6.66 0.34 1.15e-10 Alzheimer's disease (survival time); CRC cis rs7824557 0.564 rs2043508 chr8:11227406 G/A cg08071915 chr8:12219732 FAM66A 0.33 5.96 0.31 6.39e-9 Retinal vascular caliber; CRC trans rs4650994 0.967 rs4650992 chr1:178515135 A/T cg05059571 chr16:84539110 KIAA1609 -0.48 -7.28 -0.37 2.45e-12 HDL cholesterol levels;HDL cholesterol; CRC cis rs7618501 0.572 rs4688756 chr3:50040194 T/A cg24308560 chr3:49941425 MST1R -0.53 -8.77 -0.44 1.01e-16 Intelligence (multi-trait analysis); CRC cis rs10504229 0.600 rs6987243 chr8:58115406 T/C cg02290350 chr8:58132656 NA -0.58 -8.16 -0.41 7.29e-15 Developmental language disorder (linguistic errors); CRC cis rs910316 1.000 rs10136948 chr14:75511075 C/T cg08847533 chr14:75593920 NEK9 0.96 18.43 0.71 1.32e-52 Height; CRC cis rs10751667 0.666 rs7944815 chr11:959776 C/T cg23136738 chr11:925521 AP2A2 -0.42 -7.2 -0.37 4.09e-12 Alzheimer's disease (late onset); CRC cis rs2635047 0.967 rs3816125 chr18:44601611 C/T cg20026939 chr18:44788898 NA -0.26 -6.25 -0.33 1.26e-9 Educational attainment; CRC cis rs4660214 0.614 rs10888715 chr1:39699244 C/T cg11070191 chr1:39582205 MACF1 0.36 5.81 0.3 1.49e-8 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs4713118 0.662 rs149961 chr6:28015569 A/C cg06470822 chr6:28175283 NA 0.91 13.22 0.59 2.75e-32 Parkinson's disease; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg19286699 chr15:74667713 NA 0.42 6.05 0.32 4e-9 Intelligence (multi-trait analysis); CRC cis rs62064224 0.614 rs9916114 chr17:30766950 T/C cg25809561 chr17:30822961 MYO1D 0.57 9.98 0.48 1.16e-20 Schizophrenia; CRC cis rs10927875 0.688 rs2009371 chr1:16348083 A/T cg24140574 chr1:16342155 HSPB7 0.42 5.63 0.3 3.95e-8 Dilated cardiomyopathy; CRC cis rs6543140 0.964 rs6734203 chr2:103080066 G/C cg09003973 chr2:102972529 NA 0.41 5.83 0.31 1.33e-8 Blood protein levels; CRC cis rs4969178 0.965 rs12451791 chr17:76397343 G/A cg20026190 chr17:76395443 PGS1 0.4 6.2 0.32 1.73e-9 HDL cholesterol levels; CRC cis rs72634258 0.945 rs28624 chr1:8084355 G/T cg00042356 chr1:8021962 PARK7 -0.54 -6.46 -0.34 3.68e-10 Inflammatory bowel disease; CRC cis rs6860806 0.507 rs272892 chr5:131664349 C/T cg12564285 chr5:131593104 PDLIM4 0.44 7.42 0.38 9.76e-13 Breast cancer; CRC cis rs17433780 0.504 rs6428494 chr1:89472196 C/T cg09516651 chr1:89888402 LOC400759 0.35 5.62 0.3 4.09e-8 Carotid intima media thickness; CRC cis rs9486719 0.947 rs9386648 chr6:97035656 T/C cg06623918 chr6:96969491 KIAA0776 -0.81 -9.44 -0.46 7.3e-19 Migraine;Coronary artery disease; CRC cis rs9467711 0.606 rs2073530 chr6:26375243 T/C cg14345882 chr6:26364793 BTN3A2 0.64 5.63 0.3 3.85e-8 Autism spectrum disorder or schizophrenia; CRC cis rs6540559 1.000 rs6540559 chr1:209982025 G/A cg23283495 chr1:209979779 IRF6 0.42 6.93 0.36 2.22e-11 Cleft lip with or without cleft palate; CRC cis rs2062225 1.000 rs1384790 chr2:111757433 T/C cg11729679 chr2:111877065 BCL2L11 -0.56 -5.64 -0.3 3.61e-8 Monocyte count; CRC cis rs7762018 1.000 rs6941766 chr6:170131653 A/G cg17545662 chr6:170176663 C6orf70 0.57 6.49 0.34 3.18e-10 Thiazide-induced adverse metabolic effects in hypertensive patients; CRC cis rs245880 0.765 rs245893 chr7:29191507 G/C cg17163760 chr7:29186267 CPVL -0.39 -6.79 -0.35 5.41e-11 Warfarin maintenance dose; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg13014406 chr1:2323870 MORN1;RER1 0.46 6.07 0.32 3.47e-9 Anxiety disorder; CRC cis rs6445967 0.832 rs1055973 chr3:58308960 T/C cg23715586 chr3:58305044 RPP14 0.36 5.95 0.31 7.03e-9 Platelet count; CRC cis rs3733585 0.699 rs6823361 chr4:9963127 A/G cg11266682 chr4:10021025 SLC2A9 -0.48 -9.86 -0.48 2.88e-20 Cleft plate (environmental tobacco smoke interaction); CRC cis rs2032447 0.714 rs199726 chr6:25953360 G/A cg12588279 chr6:26043732 HIST1H2BB 0.4 5.84 0.31 1.28e-8 Intelligence (multi-trait analysis); CRC cis rs34381861 0.520 rs74382390 chr16:71458526 C/G cg08717414 chr16:71523259 ZNF19 -0.72 -8.08 -0.41 1.21e-14 Post bronchodilator FEV1; CRC cis rs7829975 0.714 rs11784052 chr8:8671962 C/T cg08975724 chr8:8085496 FLJ10661 0.47 7.12 0.37 6.86e-12 Mood instability; CRC cis rs2204008 0.548 rs2320740 chr12:38166421 G/A cg26384229 chr12:38710491 ALG10B 0.69 9.19 0.45 4.69e-18 Bladder cancer; CRC cis rs1707322 1.000 rs12060274 chr1:46291062 G/T cg06784218 chr1:46089804 CCDC17 0.51 8.97 0.44 2.23e-17 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs597539 0.690 rs635529 chr11:68626294 C/T cg06112835 chr11:68658793 MRPL21 0.48 7.5 0.38 6.11e-13 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs11122272 0.735 rs2749704 chr1:231526243 A/G cg06096015 chr1:231504339 EGLN1 0.4 5.98 0.31 5.78e-9 Hemoglobin concentration; CRC cis rs9381040 0.701 rs6933231 chr6:41163700 T/C cg09580153 chr6:41068724 NFYA;LOC221442 -0.43 -6.45 -0.33 4.04e-10 Alzheimer's disease (late onset); CRC cis rs883565 0.569 rs7613766 chr3:39152248 C/G cg01426195 chr3:39028469 NA -0.42 -6.99 -0.36 1.56e-11 Handedness; CRC cis rs9910055 0.659 rs3826412 chr17:42255097 A/G cg09913183 chr17:42254507 C17orf65;ASB16 0.64 10.06 0.49 6.17e-21 Total body bone mineral density; CRC cis rs2070677 0.935 rs4335491 chr10:135422460 T/G cg20169779 chr10:135381914 SYCE1 -0.96 -15.45 -0.65 7.15e-41 Gout; CRC cis rs11105298 0.891 rs10858879 chr12:89886578 A/T cg00757033 chr12:89920650 WDR51B -0.37 -6.35 -0.33 7.01e-10 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg13505011 chr12:133264131 POLE;PXMP2 0.45 6.22 0.32 1.53e-9 Anxiety disorder; CRC cis rs938554 0.736 rs13125646 chr4:9982330 A/G cg00071950 chr4:10020882 SLC2A9 0.47 6.43 0.33 4.42e-10 Blood metabolite levels; CRC cis rs1059312 0.772 rs11609637 chr12:129300202 T/G cg23521905 chr12:129298690 SLC15A4;MGC16384 0.38 6.64 0.34 1.29e-10 Systemic lupus erythematosus; CRC trans rs916888 0.773 rs199443 chr17:44819565 C/T cg07870213 chr5:140052090 DND1 0.99 11.38 0.53 1.6e-25 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs881375 0.678 rs2269060 chr9:123683569 C/T cg09586646 chr9:123605570 PSMD5;LOC253039 0.39 5.66 0.3 3.38e-8 Rheumatoid arthritis; CRC cis rs6793245 0.801 rs62239356 chr3:38587093 T/C cg01465620 chr3:38496096 LOC100128640;ACVR2B -0.46 -5.66 -0.3 3.33e-8 QT interval; CRC cis rs7618915 0.547 rs7642198 chr3:52677960 T/C cg07507251 chr3:52567010 NT5DC2 0.42 6.04 0.32 4.11e-9 Bipolar disorder; CRC cis rs11677416 1.000 rs6542091 chr2:113525311 G/A cg06156847 chr2:113672199 IL1F7 -0.4 -6.03 -0.32 4.38e-9 Response to antipsychotic treatment in schizophrenia (working memory); CRC cis rs6066835 0.572 rs12329434 chr20:47260191 T/C cg18078177 chr20:47281410 PREX1 0.79 6.13 0.32 2.56e-9 Multiple myeloma; CRC cis rs10479542 0.784 rs7702303 chr5:178986436 G/A cg21226059 chr5:178986404 RUFY1 0.4 7.22 0.37 3.6e-12 Lung cancer; CRC cis rs6546324 0.625 rs2861687 chr2:67838184 C/G cg15745817 chr2:67799979 NA -0.56 -9.64 -0.47 1.62e-19 Endometriosis; CRC cis rs929354 0.772 rs2023975 chr7:157012096 G/A cg05182265 chr7:156933206 UBE3C -0.76 -14.46 -0.62 5.17e-37 Body mass index; CRC cis rs9611565 0.659 rs9607813 chr22:41941479 G/A cg06634786 chr22:41940651 POLR3H -0.66 -7.7 -0.39 1.58e-13 Vitiligo; CRC cis rs7208859 0.673 rs2433 chr17:29226228 T/C cg13385521 chr17:29058706 SUZ12P 0.69 7.93 0.4 3.48e-14 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs9322193 0.923 rs4870529 chr6:150037572 A/G cg07701084 chr6:150067640 NUP43 0.56 8.29 0.42 2.92e-15 Lung cancer; CRC cis rs9487051 0.714 rs9487053 chr6:109619697 T/C cg21918786 chr6:109611834 NA -0.42 -7.37 -0.38 1.35e-12 Reticulocyte fraction of red cells; CRC cis rs2832191 0.740 rs2012645 chr21:30445961 G/A cg24692254 chr21:30365293 RNF160 0.85 16.11 0.66 1.88e-43 Dental caries; CRC cis rs644799 0.896 rs12146644 chr11:95492878 A/G cg03916912 chr11:95522834 CEP57;FAM76B 0.92 16.2 0.67 8.32e-44 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs889312 0.500 rs866223 chr5:56125353 A/G cg24531977 chr5:56204891 C5orf35 -0.46 -7.0 -0.36 1.42e-11 Breast cancer;Breast cancer (early onset); CRC trans rs7944735 0.545 rs4752805 chr11:48018355 A/G cg15704280 chr7:45808275 SEPT13 0.55 7.18 0.37 4.53e-12 Intraocular pressure; CRC cis rs6963495 0.769 rs73192134 chr7:105189338 T/C cg13798780 chr7:105162888 PUS7 0.65 7.53 0.38 4.96e-13 Bipolar disorder (body mass index interaction); CRC cis rs1799949 0.965 rs33988650 chr17:41287880 A/G cg05368731 chr17:41323189 NBR1 0.69 10.5 0.5 1.94e-22 Menopause (age at onset); CRC cis rs9372498 0.505 rs62422247 chr6:118987559 G/T cg22561889 chr6:118971681 C6orf204 0.53 6.53 0.34 2.43e-10 Diastolic blood pressure; CRC cis rs10782582 0.632 rs77099976 chr1:76240524 T/C cg03433033 chr1:76189801 ACADM -0.41 -5.81 -0.3 1.51e-8 Daytime sleep phenotypes; CRC cis rs3785574 0.962 rs2727332 chr17:61878584 T/A cg06601766 chr17:61851465 DDX42;CCDC47 0.6 8.62 0.43 2.81e-16 Height; CRC cis rs55883249 1.000 rs56372340 chr2:9741536 A/G cg23886495 chr2:9695866 ADAM17 0.49 5.65 0.3 3.55e-8 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; CRC cis rs1448094 0.511 rs61930074 chr12:86218759 G/C cg18827107 chr12:86230957 RASSF9 -0.43 -6.98 -0.36 1.65e-11 Major depressive disorder; CRC cis rs6951245 1.000 rs80094748 chr7:1103958 G/A cg22907277 chr7:1156413 C7orf50 0.73 7.71 0.39 1.55e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs4363385 0.747 rs6668215 chr1:152964498 A/G cg25856811 chr1:152973957 SPRR3 -0.26 -7.24 -0.37 3.15e-12 Inflammatory skin disease; CRC cis rs1862618 0.802 rs42769 chr5:56144152 G/A cg18230493 chr5:56204884 C5orf35 -0.71 -9.11 -0.45 8.07e-18 Initial pursuit acceleration; CRC cis rs7760949 0.925 rs9464420 chr6:13925892 C/T cg27413430 chr6:13925136 RNF182 0.35 6.02 0.31 4.7e-9 Mean corpuscular hemoglobin concentration; CRC cis rs7666738 0.761 rs1456210 chr4:98645932 T/G cg17366294 chr4:99064904 C4orf37 0.35 5.69 0.3 2.76e-8 Colonoscopy-negative controls vs population controls; CRC cis rs9826463 0.757 rs73238200 chr3:142204634 C/T cg20824294 chr3:142316082 PLS1 0.38 6.41 0.33 5.14e-10 QRS duration in Tripanosoma cruzi seropositivity; CRC cis rs7666738 0.830 rs1834647 chr4:98882915 G/A cg17366294 chr4:99064904 C4orf37 0.41 6.74 0.35 7.11e-11 Colonoscopy-negative controls vs population controls; CRC trans rs7618501 0.633 rs4688690 chr3:50022292 G/A cg21659725 chr3:3221576 CRBN 0.6 9.38 0.46 1.09e-18 Intelligence (multi-trait analysis); CRC trans rs13046373 0.905 rs4816372 chr21:32077414 A/T cg27546118 chr12:3931453 PARP11 -0.42 -6.66 -0.34 1.18e-10 HDL cholesterol; CRC cis rs76878669 0.561 rs4930179 chr11:66157432 C/T cg24851651 chr11:66362959 CCS -0.4 -6.94 -0.36 2.08e-11 Educational attainment (years of education); CRC cis rs4713118 0.869 rs9348775 chr6:27695329 C/T cg12273811 chr6:28175739 NA 0.52 7.39 0.38 1.2e-12 Parkinson's disease; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg19459784 chr19:5978416 RANBP3 0.48 6.72 0.35 8.11e-11 Anxiety disorder; CRC cis rs755249 0.567 rs4660690 chr1:39819503 G/A cg18385671 chr1:39797026 MACF1 -0.41 -5.77 -0.3 1.81e-8 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs13108904 0.870 rs13115355 chr4:1261576 G/A cg19318889 chr4:1322082 MAEA 0.39 5.67 0.3 3.14e-8 Obesity-related traits; CRC cis rs2456568 0.900 rs2000960 chr11:93682348 C/T cg26875233 chr11:93583750 C11orf90 -0.34 -6.69 -0.35 9.4e-11 Response to serotonin reuptake inhibitors in major depressive disorder; CRC cis rs1215050 0.791 rs7434393 chr4:98768576 T/C cg05340658 chr4:99064831 C4orf37 0.47 6.96 0.36 1.84e-11 Waist-to-hip ratio adjusted for body mass index; CRC cis rs4481887 0.741 rs28444488 chr1:248531776 C/A cg26353448 chr1:248524236 OR2T4 -0.35 -6.68 -0.35 1.02e-10 Common traits (Other); CRC cis rs9787249 0.957 rs1046988 chr1:40219065 A/G cg19912559 chr1:40204330 PPIE -0.53 -7.91 -0.4 3.99e-14 Blood protein levels; CRC trans rs875971 0.545 rs2279757 chr7:65828663 T/C cg02869306 chr7:64672164 INTS4L1 -0.43 -6.19 -0.32 1.82e-9 Aortic root size; CRC cis rs501120 0.636 rs920172 chr10:44782724 T/C cg09554077 chr10:44749378 NA 0.79 8.36 0.42 1.78e-15 Coronary artery disease;Coronary heart disease; CRC cis rs9527 0.641 rs10786732 chr10:104762535 T/C cg15744005 chr10:104629667 AS3MT -0.3 -5.96 -0.31 6.61e-9 Arsenic metabolism; CRC cis rs394563 0.591 rs237016 chr6:149744859 T/C cg11245181 chr6:149772854 ZC3H12D -0.53 -9.36 -0.46 1.3e-18 Dupuytren's disease; CRC cis rs422249 0.512 rs174546 chr11:61569830 C/T cg00603274 chr11:61596626 FADS2 -0.44 -6.4 -0.33 5.33e-10 Trans fatty acid levels; CRC cis rs9487051 0.872 rs9386794 chr6:109611521 A/C cg21918786 chr6:109611834 NA -0.45 -8.31 -0.42 2.55e-15 Reticulocyte fraction of red cells; CRC cis rs10274279 0.660 rs4716759 chr7:157374986 T/C cg26886268 chr7:157387156 PTPRN2 -0.47 -6.57 -0.34 2.02e-10 Myopia (pathological); CRC cis rs9443645 0.869 rs10943585 chr6:79502409 G/C cg05283184 chr6:79620031 NA -0.57 -9.22 -0.45 3.79e-18 Intelligence (multi-trait analysis); CRC cis rs12893668 0.703 rs12894729 chr14:104035292 G/A cg08213375 chr14:104286397 PPP1R13B 0.37 5.81 0.31 1.46e-8 Reticulocyte count; CRC cis rs4689388 0.853 rs6446479 chr4:6291737 G/C cg00701064 chr4:6280414 WFS1 0.76 12.73 0.57 1.82e-30 Type 2 diabetes and other traits;Type 2 diabetes; CRC cis rs17384381 1.000 rs12129502 chr1:85900727 T/C cg16011679 chr1:85725395 C1orf52 0.66 6.75 0.35 6.57e-11 Lobe attachment (rater-scored or self-reported); CRC cis rs2898681 0.519 rs3811781 chr4:53729166 T/G cg21521518 chr4:53727714 RASL11B 0.41 6.07 0.32 3.59e-9 Optic nerve measurement (cup area); CRC cis rs2361718 0.500 rs12451697 chr17:78100690 T/A cg21238619 chr17:78079768 GAA -0.49 -8.67 -0.43 1.99e-16 Yeast infection; CRC cis rs4319547 0.695 rs11057797 chr12:122860732 G/A cg23029597 chr12:123009494 RSRC2 0.59 7.21 0.37 3.98e-12 Body mass index; CRC cis rs270601 0.955 rs273911 chr5:131661526 C/G cg18758796 chr5:131593413 PDLIM4 0.4 6.4 0.33 5.26e-10 Acylcarnitine levels; CRC cis rs644799 1.000 rs564675 chr11:95561873 C/T cg25622487 chr11:95524042 FAM76B;CEP57 0.76 11.99 0.55 9.59e-28 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs35883536 0.566 rs10783141 chr1:101043897 G/A cg06223162 chr1:101003688 GPR88 -0.36 -6.7 -0.35 8.92e-11 Monocyte count; CRC cis rs6691722 0.503 rs2274167 chr1:24707296 C/T cg18323236 chr1:24743029 NIPAL3 0.39 5.7 0.3 2.73e-8 Response to interferon beta in multiple sclerosis; CRC cis rs67478160 0.529 rs12880413 chr14:104267407 A/G cg01849466 chr14:104193079 ZFYVE21 -0.47 -8.2 -0.41 5.63e-15 Schizophrenia; CRC cis rs6665290 0.904 rs7541033 chr1:227188371 C/A cg10327440 chr1:227177885 CDC42BPA -1.04 -22.87 -0.78 5.86e-70 Myeloid white cell count; CRC cis rs9399137 0.507 rs11759062 chr6:135381248 A/C cg22676075 chr6:135203613 NA 0.59 8.83 0.44 6.44e-17 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; CRC trans rs17685 0.796 rs3757594 chr7:75678644 G/A cg19862616 chr7:65841803 NCRNA00174 -0.97 -18.23 -0.71 8.29e-52 Coffee consumption;Coffee consumption (cups per day); CRC cis rs9611565 0.840 rs2234052 chr22:41777241 A/G cg06634786 chr22:41940651 POLR3H -0.64 -7.47 -0.38 7.49e-13 Vitiligo; CRC cis rs427941 0.610 rs201489 chr7:101749901 C/T cg06246474 chr7:101738831 CUX1 0.44 6.72 0.35 8.09e-11 Plasma omega-3 polyunsaturated fatty acid level (eicosapentaenoic acid); CRC cis rs17376456 0.825 rs13156202 chr5:93157721 C/T cg21475434 chr5:93447410 FAM172A -0.67 -7.13 -0.37 6.49e-12 Diabetic retinopathy; CRC cis rs853679 0.517 rs6932109 chr6:28078303 A/G cg12172441 chr6:28176163 NA -0.6 -7.48 -0.38 6.94e-13 Depression; CRC cis rs7647973 0.731 rs9831648 chr3:49214303 G/T cg07636037 chr3:49044803 WDR6 0.59 7.13 0.37 6.5e-12 Menarche (age at onset); CRC cis rs4481887 1.000 rs4589143 chr1:248470446 A/G cg00666640 chr1:248458726 OR2T12 0.54 9.36 0.46 1.32e-18 Common traits (Other); CRC cis rs5750830 0.649 rs5750818 chr22:39820885 A/G cg11247378 chr22:39784982 NA -0.46 -8.71 -0.43 1.55e-16 Intelligence (multi-trait analysis); CRC cis rs9467160 0.734 rs10946702 chr6:24462672 A/G cg20631270 chr6:24437470 GPLD1 -0.47 -6.91 -0.36 2.58e-11 Liver enzyme levels; CRC cis rs2239547 0.657 rs7638524 chr3:52874861 G/A cg18404041 chr3:52824283 ITIH1 -0.4 -7.5 -0.38 5.93e-13 Schizophrenia; CRC cis rs7762018 0.943 rs7772889 chr6:170142458 T/C cg17545662 chr6:170176663 C6orf70 0.57 6.45 0.34 3.99e-10 Thiazide-induced adverse metabolic effects in hypertensive patients; CRC cis rs7306456 0.623 rs10902513 chr12:132693487 A/G cg14525755 chr12:132671672 NA 0.5 8.4 0.42 1.4e-15 Anti-saccade response; CRC cis rs2762353 0.595 rs9467591 chr6:25742699 C/T cg07061783 chr6:25882402 NA -0.5 -6.64 -0.34 1.3e-10 Blood metabolite levels; CRC cis rs7809950 1.000 rs2712201 chr7:107145564 T/C cg23024343 chr7:107201750 COG5 -0.61 -8.68 -0.43 1.82e-16 Coronary artery disease; CRC trans rs4843747 0.749 rs72818535 chr16:88074039 G/A cg26811252 chr16:29126840 RRN3P2 0.71 9.86 0.48 2.86e-20 Menopause (age at onset); CRC cis rs7605827 0.893 rs741437 chr2:15626327 A/G cg19274914 chr2:15703543 NA 0.39 5.92 0.31 8.14e-9 Educational attainment (years of education); CRC cis rs1552244 0.882 rs67631672 chr3:10004768 G/A cg00166722 chr3:10149974 C3orf24 0.63 8.34 0.42 2e-15 Alzheimer's disease; CRC trans rs10982213 0.830 rs2274163 chr9:117188714 C/T cg05045343 chr2:219232747 C2orf62 0.37 6.32 0.33 8.63e-10 Interleukin-6 levels; CRC cis rs1044826 0.642 rs407958 chr3:139213632 T/C cg00490450 chr3:139108681 COPB2 0.44 6.5 0.34 3.05e-10 Obesity-related traits; CRC cis rs7591163 1.000 rs4300818 chr2:228713255 G/T cg23807890 chr2:228736357 WDR69 -0.51 -6.99 -0.36 1.56e-11 Blood pressure; CRC cis rs78663649 0.708 rs79268770 chr19:16601411 A/T cg10248733 chr19:16607483 C19orf44;CALR3 -0.87 -6.27 -0.33 1.1e-9 White blood cell count; CRC cis rs2075371 1.000 rs2598292 chr7:133988584 C/G cg11752832 chr7:134001865 SLC35B4 0.5 7.71 0.39 1.54e-13 Mean platelet volume; CRC trans rs12495832 0.778 rs78701509 chr3:147900925 T/C cg10221266 chr7:153579447 NA 0.55 5.96 0.31 6.33e-9 Chin dimples; CRC cis rs9291683 0.679 rs13137795 chr4:10051506 G/A cg11266682 chr4:10021025 SLC2A9 0.51 10.54 0.5 1.4e-22 Bone mineral density; CRC cis rs11148252 0.755 rs116860555 chr13:52936937 C/T cg02158880 chr13:53174818 NA -0.45 -6.77 -0.35 5.8e-11 Lewy body disease; CRC cis rs524281 0.692 rs10896076 chr11:65840668 A/G cg16950941 chr11:66035639 RAB1B -0.56 -7.38 -0.38 1.33e-12 Electroencephalogram traits; CRC cis rs7918232 0.698 rs6482586 chr10:27297829 A/C cg14442939 chr10:27389572 ANKRD26 0.65 7.08 0.36 8.52e-12 Breast cancer; CRC cis rs910316 0.789 rs4899552 chr14:75667921 C/A cg11812906 chr14:75593930 NEK9 -0.5 -7.31 -0.37 1.98e-12 Height; CRC cis rs4689388 0.926 rs5018647 chr4:6292799 A/C cg00701064 chr4:6280414 WFS1 0.74 12.91 0.58 3.95e-31 Type 2 diabetes and other traits;Type 2 diabetes; CRC cis rs2070677 0.542 rs7086127 chr10:135393731 T/C cg20169779 chr10:135381914 SYCE1 -0.94 -14.89 -0.63 1.09e-38 Gout; CRC cis rs4523957 0.928 rs12938295 chr17:2160854 A/G cg16513277 chr17:2031491 SMG6 0.53 8.76 0.43 1.07e-16 Autism spectrum disorder or schizophrenia;Schizophrenia; CRC cis rs6831352 0.918 rs13133633 chr4:100058697 C/G cg12011299 chr4:100065546 ADH4 -0.49 -9.27 -0.45 2.61e-18 Alcohol dependence; CRC cis rs3736485 0.899 rs6493505 chr15:51845172 T/C cg08986416 chr15:51914746 DMXL2 -0.45 -6.51 -0.34 2.83e-10 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs17711722 0.701 rs55773927 chr7:65337902 T/C cg11764359 chr7:65958608 NA 0.51 7.83 0.4 6.7e-14 Calcium levels; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg12888358 chr2:86668281 KDM3A -0.59 -9.21 -0.45 3.92e-18 Liver disease severity in Alagille syndrome; CRC cis rs9807989 0.773 rs72823661 chr2:102968716 G/A cg03938978 chr2:103052716 IL18RAP 0.36 5.92 0.31 7.92e-9 Asthma; CRC cis rs501916 0.634 rs1561479 chr15:48070157 C/G cg16110827 chr15:48056943 SEMA6D -0.46 -6.72 -0.35 8.26e-11 Inflammatory bowel disease;Ulcerative colitis; CRC cis rs9747347 1 rs9747347 chr17:79606820 T/C cg21984481 chr17:79567631 NPLOC4 -0.42 -6.83 -0.35 4.09e-11 Myopia; CRC cis rs2242116 0.734 rs4683294 chr3:46979013 C/G cg27129171 chr3:47204927 SETD2 -0.54 -7.79 -0.39 8.84e-14 Birth weight; CRC cis rs4713118 0.662 rs464312 chr6:27967591 T/A cg25164649 chr6:28176230 NA 0.62 8.82 0.44 6.67e-17 Parkinson's disease; CRC cis rs7647973 1.000 rs3870341 chr3:49584745 A/G cg20833759 chr3:49053208 WDR6;DALRD3 0.55 8.42 0.42 1.17e-15 Menarche (age at onset); CRC cis rs208520 0.690 rs207081 chr6:66773742 A/G cg07460842 chr6:66804631 NA -1.05 -14.62 -0.63 1.19e-37 Exhaled nitric oxide output; CRC cis rs769267 0.930 rs2301784 chr19:19390749 G/A cg01262667 chr19:19385393 TM6SF2 0.36 5.87 0.31 1.06e-8 Tonsillectomy; CRC cis rs28386778 0.897 rs2236737 chr17:61938100 C/T cg06601766 chr17:61851465 DDX42;CCDC47 0.42 5.79 0.3 1.63e-8 Prudent dietary pattern; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg18324576 chr14:105452433 C14orf79 0.41 6.08 0.32 3.26e-9 Intelligence (multi-trait analysis); CRC cis rs765787 0.530 rs11636404 chr15:45535861 C/G cg24006582 chr15:45444508 DUOX1 -0.54 -8.3 -0.42 2.8e-15 Uric acid levels; CRC cis rs875971 0.862 rs10240949 chr7:65804417 A/G cg12463550 chr7:65579703 CRCP -0.53 -7.51 -0.38 5.45e-13 Aortic root size; CRC cis rs2032447 0.714 rs199726 chr6:25953360 G/A cg03517284 chr6:25882590 NA -0.53 -7.42 -0.38 1.01e-12 Intelligence (multi-trait analysis); CRC trans rs10983614 1.000 rs7867776 chr9:120072627 A/G cg25858983 chr17:42295711 UBTF 0.45 6.55 0.34 2.25e-10 Survival in pancreatic cancer; CRC cis rs12826942 0.765 rs118006794 chr12:42619524 G/A cg11827402 chr12:42719852 PPHLN1;ZCRB1 0.59 6.64 0.34 1.26e-10 Coronary artery disease; CRC cis rs13315871 1.000 rs9862969 chr3:58341917 A/G cg20936604 chr3:58311152 NA -0.76 -7.23 -0.37 3.46e-12 Cholesterol, total; CRC cis rs875971 0.502 rs11769702 chr7:65720516 A/C cg05627663 chr7:65219948 SNORA22;CCT6P1 0.62 7.91 0.4 4.04e-14 Aortic root size; CRC cis rs7224610 0.931 rs7223342 chr17:53369594 A/G cg02383154 chr17:53343283 HLF -0.35 -5.88 -0.31 1.02e-8 Urate levels; CRC cis rs2439831 0.850 rs2277531 chr15:44069069 G/C cg02155558 chr15:43621948 ADAL;LCMT2 0.68 7.47 0.38 7.38e-13 Lung cancer in ever smokers; CRC cis rs1915146 0.546 rs2681919 chr10:126859029 A/G cg17191109 chr10:126851326 NA 0.44 6.16 0.32 2.13e-9 Menarche (age at onset); CRC cis rs6952808 0.501 rs3778999 chr7:2180885 G/A cg21782813 chr7:2030301 MAD1L1 0.5 8.43 0.42 1.08e-15 Bipolar disorder and schizophrenia; CRC cis rs1065852 0.526 rs2097561 chr22:42389431 T/C cg22189786 chr22:42395067 WBP2NL 0.44 6.44 0.33 4.33e-10 Response to serotonin reuptake inhibitors in major depressive disorder (plasma drug and metabolite levels); CRC cis rs10540 1.000 rs71487296 chr11:500282 G/A cg08200582 chr11:442649 ANO9 -0.72 -7.44 -0.38 9e-13 Body mass index; CRC cis rs3540 0.960 rs8025842 chr15:90995471 C/T cg04176472 chr15:90893244 GABARAPL3 0.38 6.38 0.33 5.91e-10 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; CRC cis rs1707322 1.000 rs11211200 chr1:46288352 A/G cg03146154 chr1:46216737 IPP 0.5 7.02 0.36 1.31e-11 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs9381040 0.599 rs2057001 chr6:41022947 A/G cg25110423 chr6:41068646 NFYA;LOC221442 -0.39 -6.03 -0.32 4.32e-9 Alzheimer's disease (late onset); CRC cis rs2243480 1.000 rs464895 chr7:65527106 A/G cg12463550 chr7:65579703 CRCP 0.71 6.25 0.33 1.24e-9 Diabetic kidney disease; CRC trans rs1814175 0.817 rs1851858 chr11:49855638 G/A cg03929089 chr4:120376271 NA -0.96 -18.65 -0.72 1.71e-53 Height; CRC cis rs13315871 1.000 rs35542947 chr3:58323244 C/T cg20936604 chr3:58311152 NA -0.78 -7.38 -0.38 1.34e-12 Cholesterol, total; CRC cis rs12681287 0.640 rs7820234 chr8:87350950 A/C cg27223183 chr8:87520930 FAM82B -0.52 -6.9 -0.36 2.72e-11 Caudate activity during reward; CRC cis rs1003719 0.715 rs1981433 chr21:38542223 T/G cg10648535 chr21:38446584 PIGP;TTC3 -0.48 -6.72 -0.35 7.91e-11 Eye color traits; CRC cis rs10504229 0.769 rs17804383 chr8:58151830 A/G cg05313129 chr8:58192883 C8orf71 -0.47 -6.18 -0.32 1.94e-9 Developmental language disorder (linguistic errors); CRC cis rs11122272 0.735 rs2790884 chr1:231531932 A/G cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.58 -8.69 -0.43 1.69e-16 Hemoglobin concentration; CRC cis rs2404602 0.647 rs62026889 chr15:76917885 C/T cg03037974 chr15:76606532 NA -0.53 -7.76 -0.39 1.06e-13 Blood metabolite levels; CRC cis rs853679 0.517 rs9348794 chr6:28117757 T/A cg12963246 chr6:28129442 ZNF389 0.49 5.7 0.3 2.71e-8 Depression; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg22555102 chr20:17949251 C20orf72;SNX5 0.48 6.89 0.36 2.86e-11 Anxiety disorder; CRC cis rs1707322 0.752 rs12062535 chr1:46222880 G/A cg03146154 chr1:46216737 IPP 0.67 9.77 0.47 5.65e-20 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg18634762 chr10:72968906 NA 0.44 6.11 0.32 2.89e-9 Response to antipsychotic treatment; CRC cis rs72781680 0.846 rs55707417 chr2:24029928 G/A cg08917208 chr2:24149416 ATAD2B 0.99 9.52 0.46 3.84e-19 Lymphocyte counts; CRC cis rs10927875 0.541 rs1739842 chr1:16342848 T/G cg10494257 chr1:16342123 HSPB7 0.45 6.27 0.33 1.1e-9 Dilated cardiomyopathy; CRC cis rs76878669 0.515 rs12576299 chr11:66132286 T/C cg24851651 chr11:66362959 CCS -0.38 -6.71 -0.35 8.65e-11 Educational attainment (years of education); CRC cis rs10489202 0.632 rs12401555 chr1:168069473 G/C cg24449463 chr1:168025552 DCAF6 -0.52 -7.2 -0.37 4.18e-12 Schizophrenia; CRC cis rs11168351 0.864 rs10875743 chr12:48498413 C/T cg15465823 chr12:48382534 COL2A1 -0.38 -6.26 -0.33 1.19e-9 Bipolar disorder and schizophrenia; CRC cis rs7626444 0.625 rs2669638 chr3:196477398 T/G cg12930392 chr3:196481615 PAK2 0.41 7.3 0.37 2.23e-12 Monocyte count; CRC cis rs7249142 0.549 rs1858846 chr19:19281187 T/G cg12558012 chr19:19281197 LOC729991-MEF2B;MEF2B 0.6 9.42 0.46 8.33e-19 IgG glycosylation; CRC cis rs929354 0.772 rs1182444 chr7:157024510 A/G cg16102536 chr7:156981717 UBE3C -0.4 -6.81 -0.35 4.59e-11 Body mass index; CRC cis rs10504229 0.683 rs17194529 chr8:58105647 A/G cg02725872 chr8:58115012 NA -0.59 -8.3 -0.42 2.78e-15 Developmental language disorder (linguistic errors); CRC cis rs7647973 0.710 rs34890793 chr3:49619493 C/T cg03060546 chr3:49711283 APEH 0.63 7.44 0.38 8.87e-13 Menarche (age at onset); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg19370980 chr7:94537747 PPP1R9A 0.42 6.03 0.32 4.33e-9 Response to antipsychotic treatment; CRC cis rs11971779 0.711 rs6961204 chr7:139047399 T/G cg17449086 chr7:139025432 C7orf55 -0.52 -5.71 -0.3 2.59e-8 Diisocyanate-induced asthma; CRC cis rs782590 0.902 rs7582278 chr2:55742924 C/G cg18811423 chr2:55921094 PNPT1 0.86 15.97 0.66 6.57e-43 Metabolic syndrome; CRC cis rs7833790 0.777 rs1005850 chr8:82692255 G/A cg17211192 chr8:82754475 SNX16 -0.51 -6.25 -0.33 1.29e-9 Diastolic blood pressure; CRC cis rs10540 1.000 rs35811812 chr11:498442 G/A cg03352830 chr11:487213 PTDSS2 0.66 8.3 0.42 2.68e-15 Body mass index; CRC cis rs13118159 0.801 rs13147602 chr4:1332175 A/G cg02018176 chr4:1364513 KIAA1530 0.43 6.68 0.35 1.02e-10 Longevity; CRC cis rs477895 0.713 rs7952318 chr11:63961242 G/A cg19465662 chr11:63993652 NUDT22;TRPT1 0.67 8.44 0.42 1.03e-15 Mean platelet volume; CRC cis rs9786986 0.764 rs291374 chr1:235694600 T/C cg08848088 chr1:235714526 GNG4 0.49 5.89 0.31 9.64e-9 Body mass index; CRC cis rs11212617 0.901 rs11212538 chr11:108045956 C/T cg14761454 chr11:108092087 ATM;NPAT 0.41 6.11 0.32 2.78e-9 Response to metformin in type 2 diabetes (glycemic); CRC cis rs7647973 0.600 rs12631989 chr3:49273996 C/T cg03060546 chr3:49711283 APEH 0.49 7.16 0.37 5.31e-12 Menarche (age at onset); CRC cis rs4555082 0.874 rs1882846 chr14:105717448 G/C cg18132624 chr14:105716052 BTBD6;BRF1 -0.5 -8.25 -0.41 3.98e-15 Mean platelet volume;Platelet distribution width; CRC cis rs9487051 0.714 rs9487058 chr6:109631060 A/C cg21918786 chr6:109611834 NA -0.39 -6.85 -0.35 3.7e-11 Reticulocyte fraction of red cells; CRC cis rs12971120 1.000 rs2278161 chr18:72176083 T/C cg26446133 chr18:72167187 CNDP2 -0.78 -12.19 -0.56 1.92e-28 Refractive error; CRC cis rs6951245 1.000 rs78628466 chr7:1068453 G/C cg20603222 chr7:1096387 C7orf50;GPR146 -0.69 -8.1 -0.41 1.07e-14 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg11964345 chr12:110434092 GIT2 0.37 6.01 0.31 4.85e-9 Liver disease severity in Alagille syndrome; CRC trans rs6703335 0.870 rs10803142 chr1:243598234 A/G cg05097221 chr19:11750825 NA 0.42 5.97 0.31 6.24e-9 Schizophrenia;Schizophrenia, schizoaffective disorder or bipolar disorder; CRC cis rs4713118 0.824 rs7759217 chr6:27730463 A/G cg25164649 chr6:28176230 NA 0.6 8.01 0.4 1.95e-14 Parkinson's disease; CRC cis rs13256369 0.802 rs12681925 chr8:8561649 G/A cg00074818 chr8:8560427 CLDN23 0.4 7.27 0.37 2.69e-12 Obesity-related traits; CRC cis rs17767392 0.958 rs17767446 chr14:71820963 G/A cg13720639 chr14:72061746 SIPA1L1 -0.54 -6.84 -0.35 3.91e-11 Mitral valve prolapse; CRC cis rs17826219 0.500 rs2449749 chr17:29078298 C/T cg01831904 chr17:28903510 LRRC37B2 -0.62 -6.41 -0.33 5.05e-10 Body mass index; CRC cis rs910316 1.000 rs8017642 chr14:75590822 G/A cg03030879 chr14:75389066 RPS6KL1 -0.48 -7.54 -0.38 4.52e-13 Height; CRC cis rs741668 0.895 rs61953326 chr13:46568282 T/C cg06018095 chr13:46550134 ZC3H13 0.41 5.73 0.3 2.21e-8 Cerebrospinal fluid clusterin levels; CRC cis rs916888 0.738 rs199515 chr17:44856641 C/G cg01570182 chr17:44337453 NA -1.03 -12.37 -0.56 4.17e-29 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs763121 0.853 rs5757211 chr22:39051705 C/T cg06544989 chr22:39130855 UNC84B 0.44 6.72 0.35 7.95e-11 Menopause (age at onset); CRC cis rs10504229 0.683 rs7460059 chr8:58111561 C/T cg24829409 chr8:58192753 C8orf71 -0.55 -7.9 -0.4 4.11e-14 Developmental language disorder (linguistic errors); CRC cis rs9905704 0.709 rs758378 chr17:56607746 G/C cg12560992 chr17:57184187 TRIM37 -0.5 -5.96 -0.31 6.37e-9 Testicular germ cell tumor; CRC cis rs9372498 0.536 rs55899435 chr6:118812099 C/T cg18833306 chr6:118973337 C6orf204 0.45 5.88 0.31 1.01e-8 Diastolic blood pressure; CRC cis rs6840360 1.000 rs6839074 chr4:152603357 A/G cg09659197 chr4:152720779 NA -0.51 -11.02 -0.52 3.03e-24 Intelligence (multi-trait analysis); CRC trans rs9409565 0.793 rs2486632 chr9:97196979 A/G cg05679027 chr9:99775184 HIATL2 -0.4 -6.12 -0.32 2.73e-9 Colorectal cancer (alcohol consumption interaction); CRC cis rs6502050 0.769 rs8079122 chr17:80120427 G/T cg09264619 chr17:80180166 NA -0.35 -5.93 -0.31 7.79e-9 Life satisfaction; CRC cis rs873946 0.564 rs2803992 chr10:134550882 T/C cg06453172 chr10:134556979 INPP5A -0.67 -9.38 -0.46 1.15e-18 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CRC cis rs317689 0.658 rs479971 chr12:69672471 A/G cg20891283 chr12:69753455 YEATS4 0.44 5.8 0.3 1.55e-8 Response to diuretic therapy; CRC cis rs231513 0.954 rs231479 chr17:41983616 A/G cg26893861 chr17:41843967 DUSP3 -0.64 -6.16 -0.32 2.12e-9 Cognitive function; CRC trans rs1728785 0.818 rs1645984 chr16:68628850 T/C cg04657470 chr2:198365150 HSPE1;HSPD1 0.74 8.73 0.43 1.31e-16 Ulcerative colitis; CRC cis rs9814567 1.000 rs6802654 chr3:134217072 C/T cg06541857 chr3:134203789 ANAPC13;CEP63 -0.41 -6.22 -0.32 1.48e-9 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs7605827 0.836 rs4396684 chr2:15634404 C/T cg19274914 chr2:15703543 NA 0.38 5.9 0.31 9.25e-9 Educational attainment (years of education); CRC cis rs1218582 0.772 rs4845689 chr1:154885524 A/G cg24250549 chr1:154909240 PMVK 0.65 11.3 0.53 3.18e-25 Prostate cancer; CRC cis rs11122272 0.732 rs2808605 chr1:231540187 A/C cg06096015 chr1:231504339 EGLN1 0.41 6.17 0.32 1.97e-9 Hemoglobin concentration; CRC cis rs3736594 0.513 rs62138968 chr2:27824485 C/G cg27432699 chr2:27873401 GPN1 0.65 8.29 0.42 2.95e-15 Fasting blood glucose;Fasting blood glucose (BMI interaction); CRC cis rs7208859 0.524 rs57670615 chr17:29069498 A/G cg13385521 chr17:29058706 SUZ12P 0.72 8.17 0.41 6.77e-15 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs28386778 0.897 rs2137144 chr17:61805607 G/A cg25654072 chr17:61904446 PSMC5;FTSJ3 0.69 10.68 0.51 4.76e-23 Prudent dietary pattern; CRC cis rs60871478 1.000 rs4719314 chr7:822523 A/G cg05535760 chr7:792225 HEATR2 0.84 11.13 0.52 1.27e-24 Cerebrospinal P-tau181p levels; CRC cis rs6951245 0.935 rs76525951 chr7:1096013 C/T cg24642844 chr7:1081250 C7orf50 -0.78 -9.44 -0.46 7.23e-19 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs35306767 0.903 rs11253475 chr10:907262 C/A cg26597838 chr10:835615 NA 0.95 12.02 0.55 7.69e-28 Eosinophil percentage of granulocytes; CRC cis rs2565722 0.622 rs2465873 chr6:161299972 A/G cg03159191 chr6:161285451 NA -0.46 -6.28 -0.33 1.07e-9 Blood protein levels; CRC cis rs9902453 0.845 rs58606097 chr17:28020379 G/C cg26525008 chr17:28256777 EFCAB5;SSH2 0.6 8.98 0.44 2.17e-17 Coffee consumption (cups per day); CRC cis rs9311474 0.508 rs17052259 chr3:52593138 A/G cg15147215 chr3:52552868 STAB1 -0.65 -11.31 -0.53 2.75e-25 Electroencephalogram traits; CRC cis rs4730250 0.802 rs77936580 chr7:106946343 G/A cg02696742 chr7:106810147 HBP1 -0.61 -6.77 -0.35 5.78e-11 Osteoarthritis; CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg12427896 chr2:111880694 BCL2L11 -0.56 -6.93 -0.36 2.27e-11 Diisocyanate-induced asthma; CRC cis rs7131987 0.630 rs1006409 chr12:29435675 A/G cg09582351 chr12:29534625 ERGIC2 -0.3 -6.43 -0.33 4.54e-10 QT interval; CRC cis rs992157 0.560 rs7605980 chr2:219100869 C/G cg00012203 chr2:219082015 ARPC2 0.53 8.24 0.41 4.06e-15 Colorectal cancer; CRC trans rs11252926 0.674 rs11598550 chr10:504778 A/C cg00953403 chr17:74099816 EXOC7 -0.48 -7.19 -0.37 4.33e-12 Psychosis in Alzheimer's disease; CRC cis rs55882075 0.936 rs34646062 chr5:179186318 A/G cg14593053 chr5:179126677 CANX -0.5 -8.0 -0.4 2.2e-14 Monocyte percentage of white cells; CRC cis rs2204008 0.744 rs11495519 chr12:38060546 C/A cg26384229 chr12:38710491 ALG10B 0.69 9.17 0.45 5.4e-18 Bladder cancer; CRC cis rs2857078 0.720 rs9906669 chr17:42305706 A/G cg13607699 chr17:42295918 UBTF 0.76 13.03 0.58 1.46e-31 Red cell distribution width;Reticulocyte count; CRC trans rs7395662 0.591 rs12807777 chr11:48593754 A/T cg15704280 chr7:45808275 SEPT13 -0.49 -6.9 -0.36 2.71e-11 HDL cholesterol; CRC cis rs1552244 0.882 rs67762674 chr3:10014485 C/T cg10729496 chr3:10149963 C3orf24 0.5 6.44 0.33 4.14e-10 Alzheimer's disease; CRC cis rs7493 1.000 rs7786401 chr7:95034001 G/T cg17330251 chr7:94953956 PON1 -0.59 -7.66 -0.39 2.16e-13 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs17767392 0.881 rs35620527 chr14:71915703 A/G cg13720639 chr14:72061746 SIPA1L1 -0.5 -6.41 -0.33 5.19e-10 Mitral valve prolapse; CRC cis rs7131987 0.621 rs11050181 chr12:29467669 C/T cg09582351 chr12:29534625 ERGIC2 -0.34 -7.26 -0.37 2.78e-12 QT interval; CRC cis rs2991971 0.933 rs12568144 chr1:45965307 G/A cg03123370 chr1:45965343 CCDC163P;MMACHC -0.38 -5.77 -0.3 1.87e-8 High light scatter reticulocyte count; CRC cis rs360798 0.512 rs34104251 chr2:62995183 A/G cg17519650 chr2:63277830 OTX1 -0.44 -6.06 -0.32 3.8e-9 Coronary artery disease; CRC cis rs2477686 0.526 rs1998760 chr1:2397136 C/T cg02275930 chr1:2372054 NA -0.42 -6.13 -0.32 2.58e-9 Non-obstructive azoospermia; CRC trans rs9747201 0.962 rs35051180 chr17:80135046 G/A cg07393940 chr7:158741817 NA -0.51 -7.35 -0.38 1.61e-12 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs4713118 0.955 rs9380012 chr6:27684654 A/G cg12273811 chr6:28175739 NA 0.51 6.99 0.36 1.49e-11 Parkinson's disease; CRC cis rs2425143 1.000 rs2425143 chr20:34350666 C/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.48 -6.16 -0.32 2.11e-9 Blood protein levels; CRC cis rs9462027 0.628 rs2477507 chr6:34703599 G/A cg07306190 chr6:34760872 UHRF1BP1 -0.34 -6.07 -0.32 3.49e-9 Systemic lupus erythematosus; CRC trans rs474558 0.569 rs506023 chr10:99696316 A/G cg05303249 chr11:66036138 RAB1B -0.54 -8.08 -0.41 1.24e-14 Nonsyndromic cleft lip with cleft palate; CRC cis rs7523050 0.730 rs12734623 chr1:109442654 A/G cg08274380 chr1:109419600 GPSM2 0.9 7.76 0.39 1.12e-13 Fat distribution (HIV); CRC cis rs4742903 0.935 rs726203 chr9:106906437 A/G cg21169611 chr9:106856078 SMC2 0.43 6.06 0.32 3.66e-9 High-grade serous ovarian cancer;Breast cancer; CRC cis rs34172651 0.517 rs1465423 chr16:24772680 C/G cg04756594 chr16:24857601 SLC5A11 -0.33 -7.02 -0.36 1.25e-11 Intelligence (multi-trait analysis); CRC cis rs1707322 1.000 rs6693336 chr1:46354595 C/T cg03146154 chr1:46216737 IPP 0.51 7.1 0.36 7.52e-12 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg27138088 chr11:842605 TSPAN4;POLR2L 0.42 7.13 0.37 6.61e-12 Liver disease severity in Alagille syndrome; CRC trans rs61931739 0.500 rs7965679 chr12:34542494 T/C cg26384229 chr12:38710491 ALG10B 0.59 8.77 0.44 9.64e-17 Morning vs. evening chronotype; CRC cis rs4838594 0.577 rs3888299 chr10:49687030 C/T cg17291251 chr10:49678358 ARHGAP22 0.41 6.36 0.33 6.67e-10 Daytime sleep phenotypes; CRC cis rs9747201 0.925 rs62078748 chr17:80055325 C/T cg09264619 chr17:80180166 NA 0.47 6.51 0.34 2.73e-10 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs11764590 0.671 rs56226325 chr7:2078981 C/T cg23378565 chr7:2036160 MAD1L1 -0.43 -5.91 -0.31 8.53e-9 Neuroticism; CRC cis rs7618915 0.547 rs12496634 chr3:52709259 A/C cg18404041 chr3:52824283 ITIH1 -0.43 -8.74 -0.43 1.21e-16 Bipolar disorder; CRC cis rs2836974 0.533 rs418298 chr21:40536654 A/T cg11890956 chr21:40555474 PSMG1 0.94 17.2 0.69 9.77e-48 Cognitive function; CRC cis rs1538970 0.884 rs1771551 chr1:45883643 C/G cg05343316 chr1:45956843 TESK2 0.65 9.03 0.45 1.53e-17 Platelet count; CRC cis rs921968 0.643 rs508157 chr2:219435288 G/A cg02176678 chr2:219576539 TTLL4 0.49 7.88 0.4 4.73e-14 Mean corpuscular hemoglobin concentration; CRC cis rs6504950 0.705 rs17745123 chr17:52988232 G/T cg26251398 chr17:52985966 TOM1L1 0.47 6.62 0.34 1.42e-10 Breast cancer; CRC cis rs12451471 0.559 rs1042396 chr17:78084769 G/A cg24585782 chr17:78113791 EIF4A3 -0.53 -7.38 -0.38 1.3e-12 Plateletcrit;Mean corpuscular hemoglobin concentration; CRC cis rs8070740 1.000 rs8076900 chr17:5327927 C/G cg25236894 chr17:5323110 RPAIN;NUP88 0.48 6.98 0.36 1.65e-11 Menopause (age at onset); CRC cis rs2777491 0.915 rs9302109 chr15:41612180 G/T cg18705301 chr15:41695430 NDUFAF1 -0.69 -11.44 -0.53 9.35e-26 Ulcerative colitis; CRC cis rs7659604 0.592 rs56077950 chr4:122721412 C/T cg19748678 chr4:122722346 EXOSC9 0.68 10.8 0.51 1.85e-23 Type 2 diabetes; CRC cis rs1862618 0.853 rs9283717 chr5:56078659 G/A cg20203395 chr5:56204925 C5orf35 -0.74 -8.72 -0.43 1.36e-16 Initial pursuit acceleration; CRC cis rs2842992 0.724 rs15982 chr6:160199687 T/C cg11366901 chr6:160182831 ACAT2 0.73 11.19 0.53 7.34e-25 Age-related macular degeneration (geographic atrophy); CRC trans rs2303319 0.504 rs55841284 chr2:162560011 A/G cg03774468 chr3:140950104 ACPL2 -0.64 -5.99 -0.31 5.37e-9 Cognitive function; CRC cis rs763121 0.853 rs4820345 chr22:39091151 T/C cg06022373 chr22:39101656 GTPBP1 0.77 11.21 0.53 6.25e-25 Menopause (age at onset); CRC trans rs3942852 0.774 rs2270990 chr11:48184983 G/T cg03929089 chr4:120376271 NA -0.72 -9.05 -0.45 1.27e-17 Acute lymphoblastic leukemia (childhood); CRC cis rs10751667 0.643 rs10751671 chr11:944479 T/G cg01483505 chr11:975446 AP2A2 0.44 7.24 0.37 3.16e-12 Alzheimer's disease (late onset); CRC cis rs9463078 0.809 rs6933553 chr6:45027770 T/C cg25276700 chr6:44698697 NA -0.28 -6.86 -0.35 3.35e-11 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; CRC cis rs9487051 0.676 rs6568567 chr6:109596993 A/G cg21918786 chr6:109611834 NA -0.41 -7.17 -0.37 4.84e-12 Reticulocyte fraction of red cells; CRC cis rs6088590 1.000 rs6120708 chr20:33335526 G/A cg08999081 chr20:33150536 PIGU 0.5 8.49 0.42 7.32e-16 Coronary artery disease; CRC cis rs7258465 1.000 rs8103622 chr19:18572834 C/T cg06462663 chr19:18546047 ISYNA1 0.49 7.35 0.38 1.6e-12 Breast cancer; CRC cis rs13108904 0.870 rs12506095 chr4:1262233 T/C cg05665937 chr4:1216051 CTBP1 0.4 5.92 0.31 7.95e-9 Obesity-related traits; CRC cis rs208346 0.612 rs208356 chr7:2775825 A/T cg19717773 chr7:2847554 GNA12 0.54 9.34 0.46 1.49e-18 Loneliness (linear analysis); CRC cis rs6908034 0.607 rs12529148 chr6:19806797 G/C cg02682789 chr6:19804855 NA 0.79 6.75 0.35 6.62e-11 Endometriosis;Deep ovarian and/or rectovaginal disease with dense adhesions; CRC cis rs425277 0.606 rs2257684 chr1:2077872 A/G cg12639453 chr1:2035780 PRKCZ 0.32 5.84 0.31 1.27e-8 Height; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg00323266 chr2:26256363 RAB10 0.43 6.14 0.32 2.33e-9 Intelligence (multi-trait analysis); CRC trans rs1728785 0.901 rs6499186 chr16:68660565 C/T cg04657470 chr2:198365150 HSPE1;HSPD1 0.77 9.08 0.45 1.01e-17 Ulcerative colitis; CRC cis rs1552244 1.000 rs7628448 chr3:10146828 G/A cg02579736 chr3:10068473 FANCD2;CIDECP 1.04 13.47 0.6 3.1e-33 Alzheimer's disease; CRC cis rs8103278 0.507 rs4802276 chr19:46260748 T/C cg14061069 chr19:46274453 DMPK 0.71 12.93 0.58 3.23e-31 Coronary artery disease; CRC cis rs1153858 1.000 rs61365925 chr15:45650311 T/C cg14582100 chr15:45693742 SPATA5L1 0.28 5.89 0.31 9.36e-9 Homoarginine levels; CRC cis rs780096 0.526 rs780107 chr2:27684734 A/G cg21248554 chr2:27665150 KRTCAP3 -0.33 -7.82 -0.4 7.44e-14 Total body bone mineral density; CRC cis rs5750830 0.649 rs4337572 chr22:39800704 C/G cg05872129 chr22:39784769 NA -0.63 -12.49 -0.57 1.49e-29 Intelligence (multi-trait analysis); CRC cis rs2032447 0.610 rs189911 chr6:25965942 A/G cg18357526 chr6:26021779 HIST1H4A 0.72 10.72 0.51 3.32e-23 Intelligence (multi-trait analysis); CRC cis rs4466137 0.953 rs7735476 chr5:83015140 G/C cg12199221 chr5:83017078 HAPLN1 -0.36 -5.64 -0.3 3.64e-8 Prostate cancer; CRC cis rs875971 0.619 rs12533585 chr7:65984605 G/C cg11764359 chr7:65958608 NA 0.55 8.6 0.43 3.21e-16 Aortic root size; CRC cis rs780096 0.526 rs1406295 chr2:27689700 A/G cg24768116 chr2:27665128 KRTCAP3 -0.36 -8.12 -0.41 9.76e-15 Total body bone mineral density; CRC cis rs79387448 0.745 rs1989399 chr2:103166742 G/A cg09003973 chr2:102972529 NA 0.73 8.06 0.41 1.47e-14 Gut microbiota (bacterial taxa); CRC cis rs34172651 0.917 rs8043962 chr16:24781372 A/G cg06505273 chr16:24850292 NA 0.38 5.79 0.3 1.63e-8 Intelligence (multi-trait analysis); CRC cis rs6502050 0.835 rs4789751 chr17:80092373 G/T cg25804541 chr17:80189381 SLC16A3 -0.29 -5.62 -0.3 4.17e-8 Life satisfaction; CRC cis rs2949837 0.504 rs2342396 chr7:45968087 C/G cg04796162 chr7:45961102 IGFBP3 0.37 6.55 0.34 2.21e-10 Sitting height ratio; CRC cis rs1448094 0.512 rs6539925 chr12:86244358 A/G cg19622623 chr12:86230825 RASSF9 -0.41 -6.7 -0.35 9.04e-11 Major depressive disorder; CRC cis rs7762018 0.655 rs11966349 chr6:170162537 A/G cg19338460 chr6:170058176 WDR27 0.83 8.51 0.42 6.39e-16 Thiazide-induced adverse metabolic effects in hypertensive patients; CRC cis rs875971 0.520 rs160645 chr7:65556307 A/G cg03233332 chr7:66118400 NA 0.45 6.22 0.32 1.55e-9 Aortic root size; CRC cis rs11212617 0.967 rs227074 chr11:108215095 A/G cg01991180 chr11:108092276 ATM;NPAT 0.42 6.23 0.32 1.42e-9 Response to metformin in type 2 diabetes (glycemic); CRC cis rs2252790 0.965 rs13209267 chr6:116635819 A/C cg18764771 chr6:116381957 FRK 0.21 5.76 0.3 1.94e-8 Fast beta electroencephalogram; CRC cis rs7945705 0.747 rs2568020 chr11:8994715 C/T cg21881798 chr11:8931708 C11orf17;ST5 -0.66 -11.04 -0.52 2.49e-24 Hemoglobin concentration; CRC trans rs6545883 0.931 rs12713438 chr2:61725501 G/A cg11704114 chr12:21509398 SLCO1A2 -0.32 -6.07 -0.32 3.47e-9 Tuberculosis; CRC cis rs634534 0.562 rs661335 chr11:65754061 G/A cg17985854 chr11:65770987 BANF1;EIF1AD 0.51 8.62 0.43 2.79e-16 Sum eosinophil basophil counts;Eosinophil counts; CRC trans rs10982213 0.830 rs2274163 chr9:117188714 C/T cg17465063 chr10:111985564 MXI1 0.4 6.29 0.33 9.89e-10 Interleukin-6 levels; CRC cis rs4665809 0.567 rs6546848 chr2:26444414 G/C cg27170947 chr2:26402098 FAM59B -0.63 -8.51 -0.42 6.43e-16 Gut microbiome composition (summer); CRC cis rs4629710 0.592 rs67399092 chr6:131582936 G/A cg12606694 chr6:131520996 AKAP7 0.58 8.64 0.43 2.49e-16 Multiple myeloma (IgH translocation); CRC cis rs9486719 0.656 rs6924957 chr6:96853579 G/T cg06623918 chr6:96969491 KIAA0776 0.79 10.83 0.51 1.4e-23 Migraine;Coronary artery disease; CRC cis rs7945705 0.935 rs11042102 chr11:8882164 C/T cg00186954 chr11:8933980 ST5;C11orf17 0.45 7.03 0.36 1.22e-11 Hemoglobin concentration; CRC cis rs10504229 1.000 rs1390411 chr8:58194146 C/A cg05313129 chr8:58192883 C8orf71 -0.45 -6.99 -0.36 1.56e-11 Developmental language disorder (linguistic errors); CRC cis rs10504229 0.815 rs72650877 chr8:58164510 T/C cg02725872 chr8:58115012 NA -0.59 -9.08 -0.45 1.02e-17 Developmental language disorder (linguistic errors); CRC cis rs5750830 0.594 rs6001587 chr22:39819008 T/C cg05872129 chr22:39784769 NA -0.57 -10.08 -0.49 5.26e-21 Intelligence (multi-trait analysis); CRC cis rs2228479 0.764 rs35518096 chr16:89961140 C/A cg06656553 chr16:89960601 TCF25 -0.56 -5.7 -0.3 2.62e-8 Skin colour saturation; CRC cis rs78456975 0.941 rs6755875 chr2:1557109 T/C cg12573674 chr2:1569213 NA -0.75 -7.98 -0.4 2.51e-14 Placebo response in major depressive disorder (% change in symptom score); CRC cis rs12476592 0.543 rs1446569 chr2:63818314 C/G cg10828910 chr2:63850056 LOC388955 0.49 6.06 0.32 3.75e-9 Childhood ear infection; CRC cis rs847649 0.731 rs1829957 chr7:102687010 T/A cg18108683 chr7:102477205 FBXL13 0.51 7.98 0.4 2.44e-14 Morning vs. evening chronotype; CRC cis rs812925 0.784 rs7588041 chr2:61461412 C/T cg10580144 chr2:61372316 C2orf74 -0.32 -6.62 -0.34 1.44e-10 Immature fraction of reticulocytes; CRC cis rs9457247 0.566 rs10946207 chr6:167456036 C/T cg07741184 chr6:167504864 NA 0.44 7.39 0.38 1.26e-12 Crohn's disease; CRC cis rs10751667 0.643 rs7479473 chr11:929111 C/T cg01483505 chr11:975446 AP2A2 0.43 6.87 0.35 3.26e-11 Alzheimer's disease (late onset); CRC cis rs2635047 0.542 rs2668768 chr18:44783447 A/T cg19077165 chr18:44547161 KATNAL2 -0.43 -6.5 -0.34 2.99e-10 Educational attainment; CRC cis rs1008375 0.966 rs3733581 chr4:17695206 C/G cg16339924 chr4:17578868 LAP3 -0.46 -5.77 -0.3 1.86e-8 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs7618915 0.547 rs8906 chr3:52739520 T/C cg15147215 chr3:52552868 STAB1 -0.61 -9.97 -0.48 1.27e-20 Bipolar disorder; CRC cis rs6076065 1.000 rs2424533 chr20:23375907 C/T cg11657817 chr20:23433608 CST11 0.36 5.64 0.3 3.68e-8 Facial morphology (factor 15, philtrum width); CRC cis rs7677751 0.767 rs6846502 chr4:55062090 T/C cg17187183 chr4:55093834 PDGFRA 0.48 6.81 0.35 4.55e-11 Corneal astigmatism; CRC cis rs864537 0.676 rs3108155 chr1:167422057 C/G cg09179987 chr1:167433047 CD247 0.48 7.62 0.39 2.77e-13 Celiac disease or Rheumatoid arthritis;Celiac disease; CRC cis rs1707322 0.721 rs4431884 chr1:46101323 C/T cg03146154 chr1:46216737 IPP 0.66 9.69 0.47 1.07e-19 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC trans rs7615952 0.800 rs12489350 chr3:125644116 T/C cg00769240 chr8:12517080 NA -0.58 -7.25 -0.37 3.05e-12 Blood pressure (smoking interaction); CRC trans rs66573146 0.572 rs67922134 chr4:6955772 G/A cg07817883 chr1:32538562 TMEM39B 1.1 11.91 0.55 1.96e-27 Granulocyte percentage of myeloid white cells; CRC cis rs7487075 0.786 rs12302984 chr12:46684070 A/G cg22049899 chr12:47219821 SLC38A4 0.32 6.11 0.32 2.84e-9 Itch intensity from mosquito bite; CRC cis rs9405490 0.643 rs9328059 chr6:1523076 A/G cg01806741 chr6:1527072 NA 0.66 5.91 0.31 8.57e-9 Inflammatory skin disease; CRC cis rs644799 0.544 rs499637 chr11:95569183 G/A cg25622487 chr11:95524042 FAM76B;CEP57 0.58 8.79 0.44 8.66e-17 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs8072100 0.713 rs57427906 chr17:45494014 G/A cg25173405 chr17:45401733 C17orf57 -0.43 -6.48 -0.34 3.42e-10 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs4713118 0.513 rs156734 chr6:28007357 A/C cg02683197 chr6:28174875 NA 0.6 8.31 0.42 2.55e-15 Parkinson's disease; CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg22251877 chr8:125551349 TATDN1;NDUFB9 0.37 6.21 0.32 1.64e-9 Obesity-related traits; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg09441736 chr7:101849549 CUX1 -0.4 -6.21 -0.32 1.62e-9 Liver disease severity in Alagille syndrome; CRC cis rs4481887 0.927 rs12731721 chr1:248474210 G/A cg13385794 chr1:248469461 NA 0.38 6.75 0.35 6.84e-11 Common traits (Other); CRC cis rs7727544 0.548 rs4705938 chr5:131694077 A/G cg22638593 chr5:131593259 PDLIM4 0.31 5.64 0.3 3.65e-8 Blood metabolite levels; CRC cis rs9467773 0.620 rs2504565 chr6:26656890 G/A cg09904177 chr6:26538194 HMGN4 0.73 11.41 0.53 1.28e-25 Intelligence (multi-trait analysis); CRC cis rs7666738 0.830 rs7663924 chr4:99037679 A/G cg03676636 chr4:99064102 C4orf37 -0.2 -5.84 -0.31 1.26e-8 Colonoscopy-negative controls vs population controls; CRC cis rs208520 0.690 rs176289 chr6:66766522 C/T cg07460842 chr6:66804631 NA -1.06 -14.72 -0.63 5.16e-38 Exhaled nitric oxide output; CRC cis rs9311676 0.609 rs62258080 chr3:58367493 G/A cg06643156 chr3:58380774 PXK 0.42 6.43 0.33 4.5e-10 Systemic lupus erythematosus; CRC cis rs1448094 0.654 rs7133797 chr12:86294184 G/C cg02569458 chr12:86230093 RASSF9 0.38 6.28 0.33 1.08e-9 Major depressive disorder; CRC cis rs951366 0.617 rs823080 chr1:205789282 G/A cg06877462 chr1:205807181 PM20D1 0.37 5.85 0.31 1.17e-8 Menarche (age at onset); CRC cis rs2303759 0.709 rs10411679 chr19:49826480 A/T cg22590775 chr19:49891494 CCDC155 0.6 7.9 0.4 4.3e-14 Multiple sclerosis; CRC cis rs117623576 0.887 rs211411 chr10:32394992 T/C cg03047570 chr10:32398778 NA 0.78 9.01 0.44 1.7e-17 Anti-saccade response; CRC cis rs6591182 0.504 rs7116712 chr11:65372518 A/G cg27068330 chr11:65405492 SIPA1 -0.55 -8.25 -0.41 3.87e-15 Non-alcoholic fatty liver disease histology (lobular); CRC cis rs1223397 0.651 rs2439544 chr6:13312470 G/A cg07912922 chr6:13274314 PHACTR1 0.37 5.73 0.3 2.26e-8 Blood pressure; CRC cis rs8105895 0.935 rs7256462 chr19:22281993 T/C cg02657401 chr19:22469223 NA -0.35 -5.67 -0.3 3.06e-8 Body mass index (change over time); CRC cis rs6424115 0.800 rs4649123 chr1:24197696 A/G cg10978503 chr1:24200527 CNR2 0.6 11.12 0.52 1.31e-24 Immature fraction of reticulocytes; CRC cis rs10540 1.000 rs35874808 chr11:506442 G/T cg19913688 chr11:428466 ANO9 -0.69 -7.09 -0.36 8.4e-12 Body mass index; CRC cis rs72945132 0.882 rs72949078 chr11:70217708 T/C cg14191688 chr11:70257035 CTTN 0.47 6.38 0.33 6.11e-10 Coronary artery disease; CRC cis rs9420 0.961 rs527528 chr11:57433327 C/T cg23127183 chr11:57508653 C11orf31 -0.53 -7.36 -0.38 1.52e-12 Schizophrenia; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg09844983 chr1:28240714 RPA2 0.47 6.61 0.34 1.57e-10 Response to antipsychotic treatment; CRC cis rs6495122 0.644 rs11630087 chr15:75261673 G/T cg05627522 chr15:75251581 NA 0.5 7.6 0.39 3.04e-13 Caffeine consumption;Diastolic blood pressure;Coffee consumption; CRC cis rs4523957 0.859 rs9891227 chr17:2164311 G/A cg16513277 chr17:2031491 SMG6 -0.53 -8.86 -0.44 5.18e-17 Autism spectrum disorder or schizophrenia;Schizophrenia; CRC cis rs2742540 0.503 rs2653556 chr11:8906636 C/G cg21881798 chr11:8931708 C11orf17;ST5 -0.48 -7.3 -0.37 2.24e-12 Hematocrit; CRC cis rs16867321 1.000 rs4289138 chr2:181364220 T/G cg23363182 chr2:181467187 NA -0.49 -6.09 -0.32 3.16e-9 Obesity; CRC cis rs853679 0.517 rs17774663 chr6:28120898 G/A cg25164649 chr6:28176230 NA 0.78 9.66 0.47 1.33e-19 Depression; CRC cis rs9303401 0.659 rs12946852 chr17:57013337 G/C cg02118635 chr17:56770003 RAD51C;TEX14 0.79 10.15 0.49 3.13e-21 Cognitive test performance; CRC cis rs911555 0.706 rs10129426 chr14:104018455 C/T cg12935359 chr14:103987150 CKB -0.55 -9.89 -0.48 2.38e-20 Intelligence (multi-trait analysis); CRC cis rs1062753 0.961 rs9620007 chr22:42405657 C/G cg22189786 chr22:42395067 WBP2NL 0.43 6.34 0.33 7.5e-10 Response to serotonin reuptake inhibitors in major depressive disorder (plasma drug and metabolite levels); CRC cis rs13108904 0.837 rs4519749 chr4:1280102 A/G cg19318889 chr4:1322082 MAEA 0.4 5.71 0.3 2.57e-8 Obesity-related traits; CRC cis rs140364877 1 rs140364877 chr7:1885178 C/T cg02951883 chr7:2050386 MAD1L1 -0.6 -9.56 -0.47 2.76e-19 Autism spectrum disorder or schizophrenia; CRC cis rs4700695 0.686 rs251710 chr5:65347357 G/C cg21114390 chr5:65439923 SFRS12 0.59 7.19 0.37 4.36e-12 Facial morphology (factor 19); CRC cis rs1143633 0.579 rs3811042 chr2:113670834 G/A cg06156847 chr2:113672199 IL1F7 0.5 7.7 0.39 1.6e-13 Allergic disease (asthma, hay fever or eczema); CRC cis rs17767392 1.000 rs61991203 chr14:71767841 C/G cg13720639 chr14:72061746 SIPA1L1 -0.53 -6.81 -0.35 4.7e-11 Mitral valve prolapse; CRC cis rs7552404 1.000 rs6672180 chr1:76123973 C/G cg22875332 chr1:76189707 ACADM 0.68 9.19 0.45 4.7e-18 Blood metabolite levels;Acylcarnitine levels; CRC cis rs6988636 0.710 rs62521806 chr8:124161054 C/T cg27053337 chr8:124217698 FAM83A 0.44 5.99 0.31 5.46e-9 Urinary uromodulin levels; CRC cis rs4268898 0.722 rs10445893 chr2:24407128 A/G cg06627628 chr2:24431161 ITSN2 0.45 6.68 0.35 1.03e-10 Asthma; CRC cis rs6565180 1.000 rs12930787 chr16:30381303 C/G cg17640201 chr16:30407289 ZNF48 -0.81 -13.13 -0.59 5.97e-32 Tonsillectomy; CRC trans rs4650994 1.000 rs12138541 chr1:178518707 G/A cg05059571 chr16:84539110 KIAA1609 -0.48 -7.33 -0.37 1.84e-12 HDL cholesterol levels;HDL cholesterol; CRC cis rs11105298 0.891 rs10858896 chr12:89920184 C/T cg08166232 chr12:89918718 WDR51B;GALNT4 -0.63 -7.88 -0.4 4.75e-14 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; CRC cis rs17345786 0.906 rs72944107 chr3:101197190 C/T cg12386194 chr3:101231763 SENP7 0.55 7.22 0.37 3.63e-12 Colonoscopy-negative controls vs population controls; CRC cis rs524023 0.957 rs528211 chr11:64351721 C/T cg14139581 chr11:64358342 SLC22A12 0.38 6.04 0.32 4.15e-9 Urate levels in obese individuals; CRC cis rs5769765 0.817 rs9616212 chr22:50317687 G/A cg22709217 chr22:50311962 ALG12;CRELD2 -1.05 -15.07 -0.64 2.18e-39 Schizophrenia; CRC cis rs4805272 0.539 rs11883172 chr19:29318536 C/T cg03161606 chr19:29218774 NA 0.49 5.72 0.3 2.37e-8 Plasma omega-3 polyunsaturated fatty acid levels (docosahexaenoic acid); CRC cis rs61996546 0.622 rs17646626 chr15:26867286 A/G cg15066197 chr15:26874202 GABRB3 0.39 5.98 0.31 5.87e-9 Response to methotrexate in juvenile idiopathic arthritis; CRC cis rs898097 0.841 rs55810435 chr17:80836722 G/C cg16060761 chr17:80687452 NA 0.42 6.19 0.32 1.77e-9 Breast cancer; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg08187779 chr8:102217898 ZNF706 0.49 8.59 0.43 3.47e-16 Liver disease severity in Alagille syndrome; CRC cis rs1387259 0.929 rs11168484 chr12:48633589 A/C cg24011408 chr12:48396354 COL2A1 0.46 6.35 0.33 7.23e-10 Obstructive sleep apnea trait (apnea hypopnea index); CRC cis rs9309473 1.000 rs10207220 chr2:73785046 G/C cg20560298 chr2:73613845 ALMS1 -0.48 -5.98 -0.31 5.93e-9 Metabolite levels; CRC cis rs6933660 0.536 rs3800274 chr6:151759192 T/G cg10883421 chr6:151773342 RMND1;C6orf211 0.54 7.27 0.37 2.56e-12 Menarche (age at onset); CRC trans rs11654801 0.947 rs11658178 chr17:20923489 G/A cg23759823 chr7:139672531 TBXAS1 -0.46 -6.75 -0.35 6.7e-11 Mosquito bite size; CRC cis rs6665290 0.669 rs3795445 chr1:227180947 A/C cg10327440 chr1:227177885 CDC42BPA -0.99 -20.66 -0.75 2.16e-61 Myeloid white cell count; CRC cis rs25422 0.887 rs9320666 chr6:118989181 C/T cg01339444 chr6:118972232 C6orf204 0.49 6.02 0.31 4.73e-9 Renal cell carcinoma; CRC cis rs172166 0.637 rs1233708 chr6:28173219 C/T cg21251018 chr6:28226885 NKAPL 0.47 7.25 0.37 2.99e-12 Cardiac Troponin-T levels; CRC cis rs10426930 0.700 rs10407399 chr19:5009466 A/C cg25246084 chr19:4971487 KDM4B 0.33 5.75 0.3 2.04e-8 Monocyte percentage of white cells; CRC cis rs9549367 0.673 rs575453 chr13:113837871 C/A cg24300038 chr13:113819356 PROZ 0.51 6.66 0.34 1.16e-10 Platelet distribution width; CRC cis rs12188164 0.965 rs11745789 chr5:450777 T/C cg16322479 chr5:444228 EXOC3;C5orf55 0.51 8.4 0.42 1.38e-15 Cystic fibrosis severity; CRC cis rs1150668 0.768 rs1233713 chr6:28198281 A/G cg25164649 chr6:28176230 NA 0.44 6.55 0.34 2.17e-10 Pubertal anthropometrics; CRC cis rs35146811 0.735 rs858505 chr7:99819577 G/A cg13334819 chr7:99746414 C7orf59 0.59 7.53 0.38 4.99e-13 Coronary artery disease; CRC cis rs12936587 0.748 rs11871738 chr17:17525243 A/G cg16928487 chr17:17741425 SREBF1 0.39 5.78 0.3 1.71e-8 Hip circumference;Coronary artery disease or large artery stroke;Coronary heart disease;Coronary artery disease; CRC cis rs9916302 0.861 rs8079590 chr17:37426201 T/C cg07936489 chr17:37558343 FBXL20 -0.84 -13.09 -0.59 8.67e-32 Glomerular filtration rate (creatinine); CRC cis rs8044868 0.530 rs2288000 chr16:72058881 A/G cg06172871 chr16:72088244 HP 0.39 5.69 0.3 2.82e-8 Body mass index (change over time) in cancer or chronic obstructive pulmonary disease;Body mass index (change over time) in cancer; CRC cis rs7945718 0.591 rs7102432 chr11:12700132 T/C cg25843174 chr11:12811716 TEAD1 0.41 7.44 0.38 9.02e-13 Educational attainment (years of education); CRC cis rs10504229 0.683 rs2101864 chr8:58113226 C/T cg02725872 chr8:58115012 NA -0.66 -11.64 -0.54 1.83e-26 Developmental language disorder (linguistic errors); CRC cis rs853679 0.546 rs200950 chr6:27835772 A/G cg26587870 chr6:27730563 NA -0.6 -5.91 -0.31 8.73e-9 Depression; CRC cis rs2204008 0.837 rs11168341 chr12:37961951 C/T cg26384229 chr12:38710491 ALG10B 0.68 8.97 0.44 2.26e-17 Bladder cancer; CRC cis rs1799949 1.000 rs11652332 chr17:41295489 G/A cg23758822 chr17:41437982 NA 0.82 13.8 0.61 1.67e-34 Menopause (age at onset); CRC cis rs801193 0.660 rs10950049 chr7:66230860 T/C cg18876405 chr7:65276391 NA 0.51 8.4 0.42 1.36e-15 Aortic root size; CRC trans rs12599106 0.754 rs11640596 chr16:34347277 T/C cg11235426 chr6:292522 DUSP22 -0.55 -7.67 -0.39 1.94e-13 Menopause (age at onset); CRC cis rs611744 0.604 rs13248461 chr8:109285833 C/T cg18478394 chr8:109455254 TTC35 0.41 6.39 0.33 5.56e-10 Dupuytren's disease; CRC trans rs1005277 0.505 rs200937 chr10:38135772 T/C cg27523141 chr10:43048294 ZNF37B 0.45 6.53 0.34 2.47e-10 Extrinsic epigenetic age acceleration; CRC trans rs1814175 0.616 rs10839388 chr11:49842603 C/T cg15704280 chr7:45808275 SEPT13 -0.94 -16.51 -0.67 4.81e-45 Height; CRC cis rs1552244 0.882 rs2130813 chr3:10038706 A/C cg16606324 chr3:10149918 C3orf24 0.64 8.31 0.42 2.59e-15 Alzheimer's disease; CRC cis rs6540559 1.000 rs2235373 chr1:209963803 G/A cg22029157 chr1:209979665 IRF6 0.71 9.99 0.48 1.04e-20 Cleft lip with or without cleft palate; CRC cis rs2013441 1.000 rs4924808 chr17:20026548 C/T cg13482628 chr17:19912719 NA -0.41 -6.49 -0.34 3.18e-10 Obesity-related traits; CRC cis rs7705042 0.865 rs6882226 chr5:141503870 T/A cg07392085 chr5:141489673 NDFIP1 0.46 7.24 0.37 3.13e-12 Asthma; CRC cis rs9814567 0.727 rs4543053 chr3:134351724 A/G cg06109529 chr3:134205091 CEP63;ANAPC13 -0.62 -8.82 -0.44 6.83e-17 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs4689388 0.926 rs11732178 chr4:6292643 G/C cg14416269 chr4:6271139 WFS1 0.36 5.98 0.31 5.8e-9 Type 2 diabetes and other traits;Type 2 diabetes; CRC cis rs10256972 0.616 rs6463001 chr7:1108272 A/C cg03923535 chr7:1197113 ZFAND2A 0.52 7.69 0.39 1.77e-13 Longevity;Endometriosis; CRC cis rs9527 0.568 rs12772775 chr10:104702999 C/A cg04362960 chr10:104952993 NT5C2 0.6 8.59 0.43 3.61e-16 Arsenic metabolism; CRC cis rs10911232 0.507 rs10911194 chr1:182993025 C/T ch.1.3577855R chr1:183094577 LAMC1 0.86 15.15 0.64 1.1e-39 Hypertriglyceridemia; CRC cis rs1267303 0.710 rs1535739 chr1:46957719 A/C cg08533674 chr1:46993347 NA 0.47 6.58 0.34 1.86e-10 Monobrow; CRC cis rs7849270 1.000 rs10988223 chr9:131903021 T/C cg13538475 chr9:131942899 NA -0.32 -6.23 -0.32 1.41e-9 Blood metabolite ratios; CRC cis rs4481887 1.000 rs11204626 chr1:248458974 T/A cg13385794 chr1:248469461 NA 0.36 6.29 0.33 1.02e-9 Common traits (Other); CRC cis rs2200578 1.000 rs2200578 chr2:99876244 C/T cg26064155 chr2:99771622 LIPT1;TSGA10 0.59 6.42 0.33 4.85e-10 IgG glycosylation; CRC cis rs7692995 1.000 rs7668417 chr4:18025029 G/A cg08925142 chr4:18023851 LCORL -0.53 -5.87 -0.31 1.06e-8 Height; CRC cis rs9467773 0.620 rs2451731 chr6:26624822 A/C cg09904177 chr6:26538194 HMGN4 0.72 11.32 0.53 2.52e-25 Intelligence (multi-trait analysis); CRC cis rs28386778 0.897 rs6504187 chr17:61917099 G/A cg11494091 chr17:61959527 GH2 0.63 10.75 0.51 2.7e-23 Prudent dietary pattern; CRC cis rs72634258 0.503 rs697675 chr1:7838113 A/C cg26816564 chr1:7831052 VAMP3 0.78 9.49 0.46 4.69e-19 Inflammatory bowel disease; CRC cis rs6582630 0.621 rs10880656 chr12:38571220 A/C cg13010199 chr12:38710504 ALG10B -0.43 -6.11 -0.32 2.75e-9 Drug-induced liver injury (flucloxacillin); CRC cis rs8051149 0.688 rs12444670 chr16:87870312 C/T cg01412419 chr16:87856264 NA 0.56 7.94 0.4 3.33e-14 Blood metabolite levels; CRC cis rs1949733 0.701 rs940136 chr4:8448992 G/A cg11789530 chr4:8429930 ACOX3 0.72 10.65 0.51 5.81e-23 Response to antineoplastic agents; CRC trans rs6561151 0.681 rs2325088 chr13:44424063 T/C cg17145862 chr1:211918768 LPGAT1 0.49 6.4 0.33 5.47e-10 Crohn's disease; CRC cis rs6570726 1.000 rs436066 chr6:145847127 C/T cg05347473 chr6:146136440 FBXO30 0.37 5.88 0.31 1.02e-8 Lobe attachment (rater-scored or self-reported); CRC trans rs1005277 0.579 rs2505198 chr10:38393183 A/C cg23533926 chr12:111358616 MYL2 -0.53 -8.19 -0.41 5.94e-15 Extrinsic epigenetic age acceleration; CRC cis rs11690935 0.877 rs72890834 chr2:172835802 G/T cg13550731 chr2:172543902 DYNC1I2 -1.06 -17.1 -0.69 2.27e-47 Schizophrenia; CRC cis rs34779708 0.966 rs1478463 chr10:35473035 G/A cg03585969 chr10:35415529 CREM 0.55 7.46 0.38 7.6e-13 Inflammatory bowel disease;Crohn's disease; CRC cis rs9948 0.655 rs62156221 chr2:97410850 A/G cg20312557 chr2:97357134 FER1L5 -0.6 -5.61 -0.3 4.38e-8 Erectile dysfunction and prostate cancer treatment; CRC cis rs1552244 0.882 rs67631672 chr3:10004768 G/A cg08888203 chr3:10149979 C3orf24 0.64 8.71 0.43 1.55e-16 Alzheimer's disease; CRC cis rs2712184 0.935 rs2712169 chr2:217671349 G/A cg05032264 chr2:217675019 NA -0.35 -6.0 -0.31 5.29e-9 Glomerular filtration rate;Glomerular filtration rate in non diabetics (creatinine); CRC cis rs28386778 0.897 rs1062787 chr17:61896004 T/C cg06601766 chr17:61851465 DDX42;CCDC47 0.45 6.14 0.32 2.33e-9 Prudent dietary pattern; CRC cis rs2839186 0.872 rs2250213 chr21:47674275 G/A cg09417038 chr21:47716443 C21orf57 -0.4 -6.59 -0.34 1.72e-10 Testicular germ cell tumor; CRC cis rs9322193 0.923 rs12174716 chr6:149965623 C/T cg05861140 chr6:150128134 PCMT1 -0.38 -6.13 -0.32 2.53e-9 Lung cancer; CRC cis rs782590 0.870 rs2586950 chr2:55868966 T/G cg18811423 chr2:55921094 PNPT1 0.78 12.92 0.58 3.69e-31 Metabolic syndrome; CRC cis rs514406 0.644 rs1855127 chr1:53199594 A/G cg27535305 chr1:53392650 SCP2 0.34 6.29 0.33 1.01e-9 Monocyte count; CRC cis rs62432291 0.681 rs3003173 chr6:159665692 G/T cg14500486 chr6:159655392 FNDC1 -0.75 -9.23 -0.45 3.37e-18 Joint mobility (Beighton score); CRC cis rs2108622 0.727 rs9305069 chr19:15983386 A/G cg13772218 chr19:15982569 NA 0.49 6.98 0.36 1.67e-11 Circulating phylloquinone levels;Vitamin E levels;Acenocoumarol maintenance dosage;Response to Vitamin E supplementation;Metabolite levels;Warfarin maintenance dose; CRC cis rs7542091 0.704 rs9429825 chr1:210052133 C/G cg05527609 chr1:210001259 C1orf107 -0.43 -5.67 -0.3 3.05e-8 Monobrow; CRC cis rs7044106 0.791 rs3904196 chr9:123480369 T/C cg09586646 chr9:123605570 PSMD5;LOC253039 0.66 9.77 0.47 5.98e-20 Hip circumference adjusted for BMI; CRC cis rs3091242 1.000 rs646867 chr1:25709258 A/C cg20684491 chr1:25596433 NA 0.42 7.34 0.37 1.73e-12 Erythrocyte sedimentation rate; CRC cis rs7959452 0.640 rs12370042 chr12:69692420 C/G cg14784868 chr12:69753453 YEATS4 0.75 12.17 0.56 2.24e-28 Blood protein levels; CRC trans rs7979673 1.000 rs7953554 chr12:66200778 A/G cg23076361 chr14:100622050 DEGS2 0.51 6.51 0.34 2.88e-10 Height; CRC trans rs11581859 0.950 rs55936487 chr1:99359724 T/C cg12183875 chr3:169587454 LRRC31 0.25 5.99 0.31 5.39e-9 Response to cognitive-behavioural therapy in anxiety disorder; CRC cis rs995000 0.931 rs4915840 chr1:62999595 C/G cg19896129 chr1:63156450 NA -0.45 -7.04 -0.36 1.15e-11 Triglyceride levels; CRC trans rs1814175 0.817 rs1794162 chr11:49899506 A/C cg15704280 chr7:45808275 SEPT13 -1.02 -20.55 -0.75 5.92e-61 Height; CRC cis rs4972806 0.849 rs2857541 chr2:177029086 C/T cg14324370 chr2:177042789 NA 0.8 13.03 0.58 1.36e-31 IgG glycosylation; CRC cis rs17345786 1.000 rs55641278 chr3:101290577 G/A cg12386194 chr3:101231763 SENP7 0.51 6.61 0.34 1.53e-10 Colonoscopy-negative controls vs population controls; CRC cis rs7107174 0.748 rs4415799 chr11:77976475 C/T cg02023728 chr11:77925099 USP35 -0.37 -6.35 -0.33 6.98e-10 Testicular germ cell tumor; CRC cis rs889312 0.500 rs832577 chr5:56163787 G/A cg18230493 chr5:56204884 C5orf35 -0.39 -5.77 -0.3 1.87e-8 Breast cancer;Breast cancer (early onset); CRC cis rs561341 1.000 rs483301 chr17:30293398 G/T cg00745463 chr17:30367425 LRRC37B -0.89 -9.78 -0.47 5.21e-20 Hip circumference adjusted for BMI; CRC cis rs864537 0.646 rs1723018 chr1:167433420 A/G cg09179987 chr1:167433047 CD247 0.52 8.34 0.42 2.03e-15 Celiac disease or Rheumatoid arthritis;Celiac disease; CRC cis rs4727027 0.870 rs62507509 chr7:148795522 C/T cg12479418 chr7:148823350 ZNF425;ZNF398 0.45 6.11 0.32 2.89e-9 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC cis rs2072510 0.569 rs7134975 chr12:96390420 C/A cg15438951 chr12:96389694 HAL -0.49 -5.92 -0.31 7.95e-9 Metabolite levels (small molecules and protein measures); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg07237590 chr20:62526788 DNAJC5 0.38 6.32 0.33 8.32e-10 Liver disease severity in Alagille syndrome; CRC cis rs992157 0.560 rs12987130 chr2:219104990 T/C cg04880052 chr2:219191631 PNKD -0.42 -6.66 -0.34 1.17e-10 Colorectal cancer; CRC cis rs2839186 0.709 rs2839176 chr21:47678173 A/G cg11766577 chr21:47581405 C21orf56 -0.46 -7.1 -0.36 7.85e-12 Testicular germ cell tumor; CRC cis rs6674176 0.597 rs4660262 chr1:44382524 G/A cg13606994 chr1:44402422 ARTN -0.39 -6.46 -0.34 3.76e-10 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Cognitive ability; CRC cis rs4363385 0.747 rs2879489 chr1:152970465 A/G cg25856811 chr1:152973957 SPRR3 -0.25 -6.92 -0.36 2.36e-11 Inflammatory skin disease; CRC cis rs7662987 0.517 rs1133485 chr4:100023811 T/A cg12011299 chr4:100065546 ADH4 0.49 9.27 0.46 2.46e-18 Smoking initiation; CRC cis rs7259376 0.936 rs12608491 chr19:22541627 A/G cg02657401 chr19:22469223 NA -0.34 -7.62 -0.39 2.73e-13 Menopause (age at onset); CRC cis rs8060686 0.516 rs1975802 chr16:68285847 A/G cg26727032 chr16:67993705 SLC12A4 -0.64 -9.39 -0.46 1.07e-18 HDL cholesterol;Metabolic syndrome; CRC cis rs7762018 0.556 rs78233989 chr6:170102041 C/G cg19338460 chr6:170058176 WDR27 -1.23 -11.16 -0.52 9.95e-25 Thiazide-induced adverse metabolic effects in hypertensive patients; CRC cis rs8180040 0.726 rs2305634 chr3:47043538 A/G cg27129171 chr3:47204927 SETD2 -0.68 -10.39 -0.5 4.53e-22 Colorectal cancer; CRC cis rs7647973 1.000 rs3905330 chr3:49550774 A/G cg07636037 chr3:49044803 WDR6 0.66 8.29 0.42 2.84e-15 Menarche (age at onset); CRC cis rs6840360 0.901 rs4696293 chr4:152707380 C/T cg09659197 chr4:152720779 NA -0.53 -11.57 -0.54 3.22e-26 Intelligence (multi-trait analysis); CRC cis rs801193 0.569 rs11772819 chr7:66217970 T/C cg00343986 chr7:65444356 GUSB 0.44 6.15 0.32 2.29e-9 Aortic root size; CRC cis rs477895 0.713 rs12575642 chr11:63979643 G/T cg04317338 chr11:64019027 PLCB3 0.59 7.32 0.37 1.93e-12 Mean platelet volume; CRC trans rs11148252 0.740 rs7981050 chr13:52755149 C/T cg18335740 chr13:41363409 SLC25A15 0.53 8.07 0.41 1.29e-14 Lewy body disease; CRC cis rs13315871 0.929 rs13101057 chr3:58291467 A/G cg20936604 chr3:58311152 NA -0.72 -6.84 -0.35 3.78e-11 Cholesterol, total; CRC cis rs753274 0.562 rs888876 chr19:14416793 T/C cg19560656 chr19:14444267 NA -0.39 -6.15 -0.32 2.23e-9 Tumor necrosis factor beta levels; CRC cis rs9486719 0.857 rs2971606 chr6:97043025 C/G cg06623918 chr6:96969491 KIAA0776 -0.84 -12.21 -0.56 1.56e-28 Migraine;Coronary artery disease; CRC cis rs6743376 0.556 rs1374286 chr2:113819007 C/G cg24553058 chr2:113831203 IL1F10 0.43 6.96 0.36 1.81e-11 Inflammatory biomarkers; CRC cis rs10504229 1.000 rs60651159 chr8:58174074 T/C cg24829409 chr8:58192753 C8orf71 -0.68 -11.34 -0.53 2.27e-25 Developmental language disorder (linguistic errors); CRC cis rs10504229 0.775 rs17805146 chr8:58161484 G/A cg02290350 chr8:58132656 NA -0.5 -6.21 -0.32 1.6e-9 Developmental language disorder (linguistic errors); CRC cis rs9467773 0.526 rs9688946 chr6:26367445 C/A cg09904177 chr6:26538194 HMGN4 -0.44 -6.04 -0.32 4.12e-9 Intelligence (multi-trait analysis); CRC cis rs1997103 1.000 rs12718956 chr7:55407763 A/G cg17469321 chr7:55412551 NA 0.72 11.28 0.53 3.48e-25 QRS interval (sulfonylurea treatment interaction); CRC cis rs10791323 0.582 rs2851120 chr11:133708065 A/G cg06766960 chr11:133703094 NA -0.34 -5.62 -0.3 4.14e-8 Childhood ear infection; CRC trans rs2303319 0.504 rs56260047 chr2:162497225 G/T cg01191114 chr3:48936118 SLC25A20 -0.67 -6.08 -0.32 3.35e-9 Cognitive function; CRC cis rs172166 0.694 rs2791332 chr6:28108788 C/T cg02683197 chr6:28174875 NA 0.67 9.24 0.45 3.07e-18 Cardiac Troponin-T levels; CRC cis rs9894429 0.572 rs112417725 chr17:79578219 A/G cg09655341 chr17:79618100 PDE6G 0.36 6.21 0.32 1.55e-9 Eye color traits; CRC cis rs34172651 0.917 rs7202252 chr16:24741686 T/C cg00339695 chr16:24857497 SLC5A11 -0.29 -6.5 -0.34 3.02e-10 Intelligence (multi-trait analysis); CRC cis rs11931598 1.000 rs11931598 chr4:7047102 A/G cg26116260 chr4:7069785 GRPEL1 0.49 7.58 0.39 3.6e-13 Sum basophil neutrophil counts;Sum neutrophil eosinophil counts;Granulocyte count;Neutrophil count;Myeloid white cell count; CRC cis rs11098499 0.821 rs10032151 chr4:120391628 C/T cg09307838 chr4:120376055 NA 0.7 10.83 0.51 1.42e-23 Corneal astigmatism; CRC cis rs7589728 1.000 rs12473740 chr2:88527647 A/G cg18490616 chr2:88469792 THNSL2 0.57 5.64 0.3 3.73e-8 Plasma clusterin levels; CRC cis rs892961 0.932 rs7222170 chr17:75413096 G/A cg05865280 chr17:75406074 SEPT9 0.63 14.51 0.62 3.27e-37 Airflow obstruction; CRC cis rs4716602 0.596 rs10275400 chr7:156161550 A/G cg16983916 chr7:156159713 NA -0.4 -6.9 -0.36 2.62e-11 Anti-saccade response; CRC cis rs7605827 0.930 rs1997304 chr2:15512073 G/T cg19274914 chr2:15703543 NA 0.38 5.8 0.3 1.59e-8 Educational attainment (years of education); CRC cis rs7809950 0.731 rs2712196 chr7:107128797 G/T cg23024343 chr7:107201750 COG5 -0.73 -10.06 -0.48 6.29e-21 Coronary artery disease; CRC cis rs13108904 0.870 rs12642797 chr4:1245990 G/A cg21620606 chr4:1342894 KIAA1530 0.4 7.0 0.36 1.49e-11 Obesity-related traits; CRC cis rs35264875 1.000 rs1542334 chr11:68850773 G/C cg15234197 chr11:68924956 NA 0.44 6.12 0.32 2.72e-9 Blond vs. brown hair color; CRC cis rs13315871 1.000 rs9821570 chr3:58335919 C/G cg20936604 chr3:58311152 NA -0.76 -7.22 -0.37 3.53e-12 Cholesterol, total; CRC cis rs8067545 0.750 rs4924804 chr17:19991839 C/T cg13482628 chr17:19912719 NA 0.49 7.7 0.39 1.63e-13 Schizophrenia; CRC cis rs12477438 0.765 rs6749059 chr2:99591021 G/C cg26064155 chr2:99771622 LIPT1;TSGA10 -0.81 -11.63 -0.54 2.05e-26 Chronic sinus infection; CRC cis rs62064224 0.675 rs12150479 chr17:30636200 T/A cg18200150 chr17:30822561 MYO1D 0.47 9.52 0.46 3.79e-19 Schizophrenia; CRC cis rs727563 0.593 rs5758461 chr22:42162189 G/C cg06481639 chr22:41940642 POLR3H 0.56 6.19 0.32 1.75e-9 Crohn's disease;Inflammatory bowel disease; CRC cis rs10504229 1.000 rs73607863 chr8:58170178 A/G cg05313129 chr8:58192883 C8orf71 -0.47 -6.99 -0.36 1.49e-11 Developmental language disorder (linguistic errors); CRC cis rs10504229 0.683 rs11786845 chr8:58133642 T/C cg05313129 chr8:58192883 C8orf71 -0.45 -6.27 -0.33 1.12e-9 Developmental language disorder (linguistic errors); CRC cis rs10504229 0.813 rs6999878 chr8:58197243 C/G cg21724239 chr8:58056113 NA 0.43 6.07 0.32 3.43e-9 Developmental language disorder (linguistic errors); CRC cis rs7100689 1.000 rs7100689 chr10:82222178 C/A cg00277334 chr10:82204260 NA -0.56 -6.39 -0.33 5.55e-10 Post bronchodilator FEV1; CRC trans rs2413583 0.536 rs17304621 chr22:39690791 C/T cg09612413 chr10:12085555 UPF2 -0.57 -6.2 -0.32 1.71e-9 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; CRC cis rs9322193 0.887 rs11155662 chr6:149913867 T/G cg00933542 chr6:150070202 PCMT1 0.32 6.35 0.33 7.3e-10 Lung cancer; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg19195327 chr1:6479725 HES2 0.46 6.37 0.33 6.4e-10 Thyroid stimulating hormone; CRC cis rs2050392 0.624 rs2489842 chr10:30721991 T/C cg25182066 chr10:30743637 MAP3K8 -0.45 -5.99 -0.31 5.55e-9 Inflammatory bowel disease; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg24642196 chr1:161136063 PPOX 0.47 6.45 0.34 3.89e-10 Anxiety disorder; CRC cis rs798554 0.959 rs798558 chr7:2758935 T/G cg19717773 chr7:2847554 GNA12 -0.43 -6.3 -0.33 9.55e-10 Height; CRC cis rs7312933 0.703 rs10880268 chr12:42599122 C/T cg19980929 chr12:42632907 YAF2 0.44 6.57 0.34 2.01e-10 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CRC cis rs4819052 0.851 rs9974891 chr21:46680767 T/A cg11663144 chr21:46675770 NA -0.71 -11.61 -0.54 2.44e-26 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs425277 0.583 rs12059660 chr1:2041461 C/T cg24578937 chr1:2090814 PRKCZ -0.39 -7.04 -0.36 1.09e-11 Height; CRC cis rs1790761 0.559 rs10896190 chr11:67406123 T/C cg00290607 chr11:67383545 NA 0.42 6.79 0.35 5.39e-11 Mean corpuscular volume; CRC cis rs4604732 0.589 rs78689516 chr1:247626274 C/T cg12758973 chr1:247694275 LOC148824;OR2C3 0.42 6.18 0.32 1.9e-9 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CRC cis rs897984 0.806 rs11640534 chr16:30949515 G/A cg02466173 chr16:30829666 NA 0.67 10.14 0.49 3.36e-21 Dementia with Lewy bodies; CRC cis rs11971779 0.648 rs6974099 chr7:139098566 A/T cg23387468 chr7:139079360 LUC7L2 0.41 7.05 0.36 1.04e-11 Diisocyanate-induced asthma; CRC cis rs597539 0.652 rs646586 chr11:68681653 C/T cg21963583 chr11:68658836 MRPL21 -0.56 -10.24 -0.49 1.54e-21 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC trans rs11581859 0.950 rs72728602 chr1:99372148 C/A cg12183875 chr3:169587454 LRRC31 0.27 6.36 0.33 6.74e-10 Response to cognitive-behavioural therapy in anxiety disorder; CRC cis rs3820928 0.904 rs6735069 chr2:227893660 A/G cg11843606 chr2:227700838 RHBDD1 -0.4 -5.83 -0.31 1.32e-8 Pulmonary function; CRC trans rs561341 0.769 rs9899093 chr17:30191954 C/G cg00801512 chr17:28996047 NA -0.5 -5.97 -0.31 6.13e-9 Hip circumference adjusted for BMI; CRC cis rs7949030 0.596 rs11231137 chr11:62315699 G/A cg11742103 chr11:62369870 EML3;MTA2 0.59 9.78 0.47 5.34e-20 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; CRC cis rs2880765 0.743 rs8032488 chr15:86012768 T/C cg17133734 chr15:86042851 AKAP13 0.4 6.32 0.33 8.47e-10 Coronary artery disease; CRC cis rs6860806 0.507 rs270608 chr5:131648406 C/T cg20512303 chr5:131592959 PDLIM4 0.41 6.96 0.36 1.89e-11 Breast cancer; CRC cis rs1451375 0.698 rs11238214 chr7:50636018 A/G cg14593290 chr7:50529359 DDC 0.51 7.14 0.37 5.98e-12 Malaria; CRC cis rs66486766 1 rs66486766 chr15:84806060 G/A cg17507749 chr15:85114479 UBE2QP1 0.75 11.08 0.52 1.85e-24 Bipolar disorder lithium response (categorical) or schizophrenia; CRC cis rs6747952 0.866 rs4663854 chr2:239083167 C/T cg07480446 chr2:239069576 NA 0.37 6.86 0.35 3.46e-11 Mean corpuscular hemoglobin concentration; CRC cis rs889312 0.500 rs185219 chr5:56136492 A/G cg03609598 chr5:56110824 MAP3K1 -0.42 -5.73 -0.3 2.31e-8 Breast cancer;Breast cancer (early onset); CRC cis rs13256369 0.802 rs12681925 chr8:8561649 G/A cg17143192 chr8:8559678 CLDN23 0.51 6.57 0.34 2.01e-10 Obesity-related traits; CRC cis rs9303542 0.625 rs8064626 chr17:46567851 G/A cg04904318 chr17:46607828 HOXB1 -0.51 -5.81 -0.31 1.44e-8 Ovarian cancer;Epithelial ovarian cancer; CRC cis rs1953600 0.837 rs2236556 chr10:81932790 T/C cg00277334 chr10:82204260 NA 0.37 5.97 0.31 6.06e-9 Sarcoidosis; CRC cis rs3733585 0.775 rs13124007 chr4:10043931 G/C cg00071950 chr4:10020882 SLC2A9 0.63 11.19 0.52 7.86e-25 Cleft plate (environmental tobacco smoke interaction); CRC cis rs769267 0.965 rs12977937 chr19:19429975 C/G cg01262667 chr19:19385393 TM6SF2 0.38 6.24 0.33 1.36e-9 Tonsillectomy; CRC cis rs2645694 0.626 rs2703116 chr4:77824289 C/T cg18351406 chr4:77819688 ANKRD56 -0.46 -7.13 -0.37 6.44e-12 Emphysema distribution in smoking; CRC cis rs6502050 0.805 rs62078303 chr17:80085210 A/G cg19223190 chr17:80058835 NA -0.39 -6.24 -0.33 1.31e-9 Life satisfaction; CRC cis rs17711722 0.701 rs4467826 chr7:65368708 A/G cg02869306 chr7:64672164 INTS4L1 -0.35 -5.86 -0.31 1.14e-8 Calcium levels; CRC cis rs3204270 0.810 rs62077191 chr17:79678063 A/G cg09655341 chr17:79618100 PDE6G 0.62 7.1 0.36 7.87e-12 Dental caries; CRC cis rs1348850 0.519 rs13034781 chr2:178523550 C/A cg22681709 chr2:178499509 PDE11A -0.41 -7.52 -0.38 5.1e-13 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs2811415 0.597 rs35944498 chr3:127731662 T/C cg13719885 chr3:127795394 NA -0.39 -5.96 -0.31 6.45e-9 Lung function (FEV1/FVC); CRC cis rs4862750 0.914 rs1346127 chr4:187876389 C/T cg10295955 chr4:187884368 NA 0.99 23.22 0.79 2.59e-71 Lobe attachment (rater-scored or self-reported); CRC cis rs1552244 1.000 rs56394721 chr3:10150795 A/G cg00166722 chr3:10149974 C3orf24 0.7 9.23 0.45 3.28e-18 Alzheimer's disease; CRC cis rs7412746 0.658 rs4537557 chr1:150734436 A/G cg15448220 chr1:150897856 SETDB1 0.54 7.59 0.39 3.39e-13 Melanoma; CRC cis rs9942416 0.660 rs17563863 chr5:74998334 G/A cg19683494 chr5:74908142 NA 0.49 6.21 0.32 1.57e-9 Age-related disease endophenotypes; CRC cis rs8058578 0.775 rs8046391 chr16:30836648 G/C cg02466173 chr16:30829666 NA -0.87 -14.13 -0.61 9.55e-36 Multiple myeloma; CRC cis rs597539 0.617 rs669659 chr11:68635623 G/C cg21963583 chr11:68658836 MRPL21 0.59 10.73 0.51 3.12e-23 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs1007738 0.580 rs11039028 chr11:46944196 G/A cg19486271 chr11:47235900 DDB2 0.47 6.3 0.33 9.81e-10 Bone mineral density (hip); CRC cis rs11971779 0.590 rs9642120 chr7:139083971 C/T cg07862535 chr7:139043722 LUC7L2 0.57 7.35 0.38 1.61e-12 Diisocyanate-induced asthma; CRC trans rs2727020 0.619 rs1829979 chr11:49436875 T/G cg15704280 chr7:45808275 SEPT13 -0.73 -9.21 -0.45 3.84e-18 Coronary artery disease; CRC cis rs9467711 0.591 rs10484435 chr6:26031811 A/C cg08501292 chr6:25962987 TRIM38 1.07 9.68 0.47 1.19e-19 Autism spectrum disorder or schizophrenia; CRC cis rs11098499 0.863 rs59732491 chr4:120489588 G/C cg24375607 chr4:120327624 NA 0.51 7.54 0.38 4.72e-13 Corneal astigmatism; CRC cis rs9611565 0.546 rs739134 chr22:42089623 T/C cg03806693 chr22:41940476 POLR3H 0.99 13.07 0.58 9.68e-32 Vitiligo; CRC cis rs10512697 0.803 rs11742420 chr5:3579874 A/C cg19473799 chr5:3511975 NA -0.72 -5.69 -0.3 2.81e-8 Immune response to smallpox vaccine (IL-6); CRC cis rs780094 0.500 rs12467476 chr2:27825715 T/C cg27432699 chr2:27873401 GPN1 0.48 6.11 0.32 2.82e-9 Calcium levels;Fasting blood insulin;Metabolic traits;Triglyceride levels;Fasting plasma glucose;Urate levels in overweight individuals;Urate levels in obese individuals;Uric acid levels;Height;Age-related diseases, mortality and associated endophenotypes;Renal underexcretion gout;Fasting blood glucose (BMI interaction);Urate levels;Gondoic acid (20:1n-9) levels;Fasting blood insulin (BMI interaction);Triglycerides;Plasma omega-3 polyunsaturated fatty acid levels (docosapentaenoic acid);Type 2 diabetes;Nonalcoholic fatty liver disease;Hypertriglyceridemia;C-reactive protein;Age-related disease endophenotypes;LDL cholesterol;Metabolic syndrome;Crohn's disease;Alcohol consumption (drinks per week);Homeostasis model assessment of insulin resistance;Alcohol consumption;Red blood cell count;Fasting blood glucose; CRC trans rs7615952 0.546 rs111812401 chr3:125361495 G/A cg21747405 chr11:67723411 NA -0.49 -6.36 -0.33 6.71e-10 Blood pressure (smoking interaction); CRC cis rs1570884 0.767 rs3751384 chr13:50123622 G/C cg08779649 chr13:50194554 NA 0.33 6.33 0.33 8.2e-10 Sum basophil neutrophil counts;Sum neutrophil eosinophil counts;Neutrophil count;Myeloid white cell count;Granulocyte count; CRC cis rs10463316 0.894 rs4099171 chr5:150766623 C/T cg03212797 chr5:150827313 SLC36A1 -0.5 -7.85 -0.4 6.1e-14 Metabolite levels (Pyroglutamine); CRC cis rs62244186 0.566 rs55901755 chr3:44834707 C/T cg11003573 chr3:44754125 ZNF502 -0.33 -5.64 -0.3 3.7e-8 Depressive symptoms; CRC cis rs116095464 0.558 rs10055993 chr5:264296 A/C cg22496380 chr5:211416 CCDC127 -1.01 -9.66 -0.47 1.33e-19 Breast cancer; CRC cis rs3015497 0.789 rs3015496 chr14:51114051 T/C cg09863266 chr14:51125203 SAV1 -0.31 -5.77 -0.3 1.86e-8 Mean platelet volume; CRC cis rs10504229 0.683 rs6995355 chr8:58113870 C/T cg04204079 chr8:58130323 NA -0.45 -5.84 -0.31 1.27e-8 Developmental language disorder (linguistic errors); CRC cis rs62432291 0.681 rs420137 chr6:159652931 G/C cg14500486 chr6:159655392 FNDC1 -0.75 -10.17 -0.49 2.55e-21 Joint mobility (Beighton score); CRC cis rs11148252 1.000 rs4886018 chr13:52990717 C/T cg02158880 chr13:53174818 NA 0.43 6.62 0.34 1.46e-10 Lewy body disease; CRC cis rs1728785 0.818 rs1069289 chr16:68585317 C/A cg02972257 chr16:68554789 NA -0.62 -7.27 -0.37 2.57e-12 Ulcerative colitis; CRC cis rs10504229 0.683 rs66893068 chr8:58144238 A/G cg22535103 chr8:58192502 C8orf71 -0.7 -9.43 -0.46 7.51e-19 Developmental language disorder (linguistic errors); CRC cis rs6586163 0.509 rs2031610 chr10:90754487 T/C cg13456138 chr10:90753195 FAS 0.41 5.75 0.3 2.06e-8 Chronic lymphocytic leukemia; CRC cis rs10461617 0.617 rs1423623 chr5:56065575 A/G cg12311346 chr5:56204834 C5orf35 0.46 6.39 0.33 5.59e-10 Type 2 diabetes; CRC trans rs7618501 0.633 rs11130234 chr3:50024758 G/T cg21659725 chr3:3221576 CRBN 0.6 9.38 0.46 1.09e-18 Intelligence (multi-trait analysis); CRC cis rs929354 0.713 rs10085650 chr7:156993413 T/C cg05182265 chr7:156933206 UBE3C -0.76 -14.51 -0.62 3.13e-37 Body mass index; CRC cis rs9462846 0.919 rs34433785 chr6:42887693 A/C cg02353165 chr6:42928485 GNMT 0.5 6.41 0.33 5.11e-10 Blood protein levels; CRC cis rs11001819 0.562 rs10824419 chr10:78268635 C/T cg18941641 chr10:78392320 NA 0.34 5.73 0.3 2.29e-8 Pulmonary function (smoking interaction);Pulmonary function; CRC cis rs736408 0.608 rs35004449 chr3:52852897 G/T cg10802521 chr3:52805072 NEK4 -0.46 -6.24 -0.33 1.32e-9 Bipolar disorder; CRC cis rs28386778 0.897 rs2584626 chr17:61903179 A/G cg23090583 chr17:61904693 PSMC5;FTSJ3 1.05 20.68 0.75 1.83e-61 Prudent dietary pattern; CRC cis rs10504229 0.683 rs16921817 chr8:58107563 A/T cg21724239 chr8:58056113 NA 0.52 6.99 0.36 1.58e-11 Developmental language disorder (linguistic errors); CRC cis rs7727544 0.735 rs272884 chr5:131668654 G/C cg24060327 chr5:131705240 SLC22A5 -0.38 -6.23 -0.32 1.41e-9 Blood metabolite levels; CRC cis rs6918586 0.658 rs198840 chr6:26112164 T/G cg18357526 chr6:26021779 HIST1H4A -0.49 -7.4 -0.38 1.16e-12 Schizophrenia; CRC trans rs7615952 0.641 rs61048217 chr3:125807905 G/T cg07211511 chr3:129823064 LOC729375 -0.71 -9.4 -0.46 9.34e-19 Blood pressure (smoking interaction); CRC cis rs4727027 0.933 rs917123 chr7:148848358 G/A cg12479418 chr7:148823350 ZNF425;ZNF398 0.44 5.99 0.31 5.36e-9 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC cis rs7786808 0.741 rs35059736 chr7:158224692 C/T cg17401720 chr7:158221031 PTPRN2 0.46 7.35 0.38 1.63e-12 Obesity-related traits; CRC cis rs6495367 1.000 rs745030 chr15:79381705 G/A cg17916960 chr15:79447300 NA 0.43 6.87 0.35 3.17e-11 Spherical equivalent (joint analysis main effects and education interaction); CRC cis rs7811142 1.000 rs7787620 chr7:100089234 A/G cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.74 9.96 0.48 1.4e-20 Platelet count; CRC cis rs2204008 0.837 rs11611861 chr12:38357459 A/G cg13010199 chr12:38710504 ALG10B 0.47 6.3 0.33 9.3e-10 Bladder cancer; CRC cis rs72634258 0.842 rs6668846 chr1:8152102 C/G cg00042356 chr1:8021962 PARK7 -0.55 -6.08 -0.32 3.36e-9 Inflammatory bowel disease; CRC cis rs17384381 0.861 rs2300640 chr1:85823795 C/G cg16011679 chr1:85725395 C1orf52 0.66 6.72 0.35 7.79e-11 Lobe attachment (rater-scored or self-reported); CRC cis rs1891275 0.515 rs7911755 chr10:93489817 G/A cg07889827 chr10:93443413 NA -0.39 -6.48 -0.34 3.42e-10 Intelligence (multi-trait analysis); CRC cis rs796364 1.000 rs11694369 chr2:200741720 G/A cg25936922 chr2:200820526 C2orf60;C2orf47 -0.77 -7.49 -0.38 6.19e-13 Schizophrenia; CRC cis rs7927771 0.524 rs61895760 chr11:47794538 G/C cg20307385 chr11:47447363 PSMC3 0.45 6.57 0.34 1.92e-10 Subjective well-being; CRC cis rs9911578 0.835 rs1990008 chr17:56459408 C/G cg05425664 chr17:57184151 TRIM37 0.45 6.86 0.35 3.4e-11 Intelligence (multi-trait analysis); CRC cis rs7937682 0.632 rs4935811 chr11:111679262 C/T cg09085632 chr11:111637200 PPP2R1B 0.95 15.1 0.64 1.71e-39 Primary sclerosing cholangitis; CRC cis rs713587 0.525 rs11687089 chr2:25082926 T/C cg04586622 chr2:25135609 ADCY3 -0.56 -10.49 -0.5 2.11e-22 Body mass index in non-asthmatics; CRC cis rs6831352 1.000 rs1126673 chr4:100045616 C/T cg13256891 chr4:100009986 ADH5 0.61 8.62 0.43 2.84e-16 Alcohol dependence; CRC cis rs561341 0.883 rs886224 chr17:30229902 T/C cg23018236 chr17:30244563 NA -0.62 -7.78 -0.39 9.36e-14 Hip circumference adjusted for BMI; CRC cis rs7772486 0.754 rs9390356 chr6:146118983 A/T cg05347473 chr6:146136440 FBXO30 -0.39 -5.84 -0.31 1.26e-8 Lobe attachment (rater-scored or self-reported); CRC cis rs12898370 0.561 rs8028830 chr15:77508046 A/G cg10437265 chr15:77819839 NA 0.53 6.24 0.33 1.39e-9 Risky sexual behaviors (alcohol dependence interaction); CRC cis rs9303280 0.617 rs6503525 chr17:38095174 C/G cg24910161 chr17:38119198 GSDMA 0.33 5.86 0.31 1.15e-8 Self-reported allergy; CRC cis rs11098499 0.722 rs1814814 chr4:120258124 C/G cg24375607 chr4:120327624 NA 0.49 7.84 0.4 6.36e-14 Corneal astigmatism; CRC cis rs8180040 0.726 rs13094672 chr3:47149439 C/T cg02527881 chr3:46936655 PTH1R -0.4 -7.28 -0.37 2.4e-12 Colorectal cancer; CRC trans rs875971 0.660 rs2191268 chr7:66110224 C/T cg13182412 chr17:73776098 H3F3B -0.42 -6.45 -0.34 4.03e-10 Aortic root size; CRC trans rs7923837 0.650 rs10882098 chr10:94444793 C/T cg27121462 chr16:89883253 FANCA -0.39 -6.06 -0.32 3.7e-9 Body mass index;Multiple sclerosis; CRC cis rs3892630 0.588 rs12610342 chr19:33250690 C/T cg22980127 chr19:33182716 NUDT19 0.93 12.6 0.57 5.76e-30 Red blood cell traits; CRC cis rs9611565 0.921 rs5751080 chr22:41736267 A/G cg06634786 chr22:41940651 POLR3H -0.4 -5.67 -0.3 3.19e-8 Vitiligo; CRC cis rs62408225 0.925 rs6925032 chr6:91008027 C/A cg06866423 chr6:90926672 BACH2 0.49 8.03 0.4 1.73e-14 Eosinophil counts;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC trans rs7937682 0.924 rs501089 chr11:111502479 G/T cg18187862 chr3:45730750 SACM1L -0.5 -7.22 -0.37 3.74e-12 Primary sclerosing cholangitis; CRC cis rs172166 0.516 rs2791333 chr6:28111114 A/G cg10876282 chr6:28092338 ZSCAN16 0.4 5.7 0.3 2.62e-8 Cardiac Troponin-T levels; CRC cis rs875971 0.862 rs778736 chr7:65813848 C/T cg11764359 chr7:65958608 NA 0.58 8.58 0.43 3.7e-16 Aortic root size; CRC cis rs1150668 0.830 rs2859365 chr6:28391465 C/T cg21251018 chr6:28226885 NKAPL -0.48 -8.3 -0.42 2.76e-15 Pubertal anthropometrics; CRC cis rs11148252 1.000 rs11148252 chr13:53009048 C/T cg00495681 chr13:53174319 NA 0.55 8.46 0.42 8.83e-16 Lewy body disease; CRC cis rs2898681 0.519 rs76606067 chr4:53728221 G/T cg21521518 chr4:53727714 RASL11B 0.4 5.93 0.31 7.81e-9 Optic nerve measurement (cup area); CRC cis rs2882667 0.898 rs11950819 chr5:138397100 T/C cg04439458 chr5:138467593 SIL1 -0.32 -5.93 -0.31 7.55e-9 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs9303401 0.659 rs12946397 chr17:56769979 C/T cg02118635 chr17:56770003 RAD51C;TEX14 0.79 10.13 0.49 3.5e-21 Cognitive test performance; CRC cis rs1538970 0.962 rs9429077 chr1:45820667 C/A cg05343316 chr1:45956843 TESK2 0.68 9.18 0.45 4.78e-18 Platelet count; CRC cis rs2354432 0.556 rs34602039 chr1:146850972 G/A cg25205988 chr1:146714368 CHD1L -1.21 -10.07 -0.49 5.77e-21 Mitochondrial DNA levels; CRC cis rs2739330 0.796 rs5760106 chr22:24250645 A/C cg10150615 chr22:24372951 LOC391322 0.61 9.13 0.45 7.04e-18 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs4713118 0.513 rs149975 chr6:27986340 G/A cg12273811 chr6:28175739 NA 0.59 8.66 0.43 2.22e-16 Parkinson's disease; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg12760041 chr2:211036890 C2orf67 -0.46 -7.07 -0.36 9.28e-12 Liver disease severity in Alagille syndrome; CRC cis rs1577917 1.000 rs12663690 chr6:86640162 C/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A 0.53 6.98 0.36 1.61e-11 Response to antipsychotic treatment; CRC cis rs9368481 0.761 rs9348746 chr6:26970357 C/G cg07220782 chr6:26987966 LOC100270746;C6orf41 -0.44 -6.22 -0.32 1.49e-9 Autism spectrum disorder or schizophrenia; CRC cis rs9287719 0.967 rs7608498 chr2:10738428 G/A cg00105475 chr2:10696890 NA 0.45 7.3 0.37 2.19e-12 Prostate cancer; CRC cis rs2050392 0.517 rs2771242 chr10:30762973 C/T cg18806716 chr10:30721971 MAP3K8 -0.6 -8.32 -0.42 2.35e-15 Inflammatory bowel disease; CRC trans rs11148252 0.538 rs9526842 chr13:52727723 T/G cg18335740 chr13:41363409 SLC25A15 0.54 8.15 0.41 7.45e-15 Lewy body disease; CRC trans rs4689592 0.587 rs6825954 chr4:7074226 T/C cg07817883 chr1:32538562 TMEM39B -0.63 -7.84 -0.4 6.13e-14 Monocyte percentage of white cells; CRC trans rs4942242 0.663 rs9590779 chr13:44234886 A/G cg27382691 chr15:76552771 ETFA;TYRO3P 0.5 6.24 0.33 1.33e-9 Response to tocilizumab in rheumatoid arthritis; CRC cis rs2370759 1.000 rs11594963 chr10:32625736 G/A cg01819863 chr10:32635814 EPC1 1.1 13.26 0.59 1.87e-32 Sexual dysfunction (female); CRC trans rs4942242 0.967 rs58325557 chr13:44217771 A/G cg19169023 chr15:41853346 TYRO3 0.53 7.9 0.4 4.26e-14 Response to tocilizumab in rheumatoid arthritis; CRC cis rs2243480 1.000 rs4718309 chr7:65627764 G/C cg12463550 chr7:65579703 CRCP -0.71 -6.52 -0.34 2.65e-10 Diabetic kidney disease; CRC cis rs709400 0.627 rs55859054 chr14:103953666 T/A cg12935359 chr14:103987150 CKB -0.51 -8.29 -0.42 2.98e-15 Body mass index; CRC trans rs11148252 0.669 rs4884320 chr13:53006914 T/C cg18335740 chr13:41363409 SLC25A15 0.49 6.99 0.36 1.53e-11 Lewy body disease; CRC trans rs4873772 0.834 rs7842068 chr8:48582964 A/G cg05343739 chr1:154731938 KCNN3 0.36 6.58 0.34 1.83e-10 Lobe attachment (rater-scored or self-reported); CRC cis rs7085104 0.632 rs7097872 chr10:104606636 C/T cg15744005 chr10:104629667 AS3MT -0.35 -7.3 -0.37 2.13e-12 Immature fraction of reticulocytes;Schizophrenia; CRC cis rs6547741 0.775 rs11692692 chr2:27861707 G/A cg27432699 chr2:27873401 GPN1 -0.86 -16.8 -0.68 3.46e-46 Oral cavity cancer; CRC cis rs7246657 1.000 rs12709812 chr19:37794850 A/G cg23950597 chr19:37808831 NA 0.5 5.95 0.31 6.83e-9 Coronary artery calcification; CRC cis rs7909074 0.509 rs2183994 chr10:45389940 T/C cg04218760 chr10:45406644 TMEM72 -0.3 -7.35 -0.38 1.58e-12 Mean corpuscular volume; CRC cis rs7647973 0.710 rs11130208 chr3:49615624 G/T cg03060546 chr3:49711283 APEH 0.66 7.37 0.38 1.41e-12 Menarche (age at onset); CRC cis rs929596 0.556 rs35984508 chr2:234587852 G/A cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.45 -7.11 -0.36 7.49e-12 Total bilirubin levels in HIV-1 infection; CRC cis rs73206853 0.764 rs73205079 chr12:110599953 C/T cg12870014 chr12:110450643 ANKRD13A 0.83 10.77 0.51 2.35e-23 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC cis rs9611565 0.840 rs4822025 chr22:41776646 C/G cg03806693 chr22:41940476 POLR3H -1.07 -13.81 -0.61 1.62e-34 Vitiligo; CRC cis rs6714710 0.627 rs11680883 chr2:98472610 T/C cg26665480 chr2:98280029 ACTR1B 0.55 7.36 0.38 1.51e-12 Posterior cortical atrophy and Alzheimer's disease; CRC cis rs4713118 0.739 rs2893931 chr6:27748010 G/A cg26587870 chr6:27730563 NA -0.45 -6.55 -0.34 2.18e-10 Parkinson's disease; CRC cis rs4629180 0.593 rs6707517 chr2:102089878 C/T cg01388757 chr2:102091195 RFX8 -0.62 -8.77 -0.44 9.74e-17 Chronic rhinosinusitis with nasal polyps; CRC cis rs6500602 0.727 rs2058811 chr16:4575162 C/T cg08645402 chr16:4508243 NA 0.62 11.01 0.52 3.2e-24 Schizophrenia; CRC cis rs4880487 0.505 rs883660 chr10:1206834 A/G cg10055817 chr10:1229050 ADARB2 0.4 6.74 0.35 7.12e-11 Migraine; CRC cis rs11122272 0.735 rs2486735 chr1:231521778 C/T cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.54 -8.14 -0.41 7.99e-15 Hemoglobin concentration; CRC cis rs9788333 0.962 rs61951450 chr13:21886354 G/A cg23743428 chr13:21893420 NA -0.47 -9.09 -0.45 9.81e-18 Thiazide-induced adverse metabolic effects in hypertensive patients; CRC cis rs2204008 0.754 rs11514074 chr12:38401128 C/T cg26384229 chr12:38710491 ALG10B 0.69 9.19 0.45 4.52e-18 Bladder cancer; CRC cis rs1348850 0.958 rs10497501 chr2:178462299 C/G cg02961200 chr2:178257176 LOC100130691;AGPS 0.52 7.53 0.38 4.83e-13 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs832540 1.000 rs252913 chr5:56195846 C/T cg12311346 chr5:56204834 C5orf35 0.41 6.24 0.33 1.33e-9 Coronary artery disease; CRC cis rs2072499 0.695 rs112223391 chr1:156156094 G/A cg25208724 chr1:156163844 SLC25A44 1.0 15.79 0.66 3.31e-42 Testicular germ cell tumor; CRC trans rs4263408 0.934 rs9683743 chr4:39703194 A/C cg16322302 chr3:49157769 USP19 -0.41 -6.21 -0.32 1.59e-9 Plasma amyloid beta peptide concentrations (ABx-40); CRC cis rs10911232 0.507 rs2151669 chr1:183055398 T/G ch.1.3577855R chr1:183094577 LAMC1 0.84 14.59 0.63 1.55e-37 Hypertriglyceridemia; CRC cis rs8060686 0.516 rs8044995 chr16:68189340 G/A cg26727032 chr16:67993705 SLC12A4 -0.58 -8.66 -0.43 2.08e-16 HDL cholesterol;Metabolic syndrome; CRC cis rs6456156 0.774 rs2021999 chr6:167529766 G/C cg05540913 chr6:167530185 CCR6 -0.42 -7.48 -0.38 6.66e-13 Primary biliary cholangitis; CRC cis rs17767392 0.595 rs61174376 chr14:71654869 C/T cg13720639 chr14:72061746 SIPA1L1 -0.47 -6.04 -0.32 4.21e-9 Mitral valve prolapse; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg04028315 chr7:21467710 SP4 0.42 6.33 0.33 8.15e-10 Intelligence (multi-trait analysis); CRC cis rs6547741 0.844 rs55826602 chr2:27863452 A/G cg27432699 chr2:27873401 GPN1 -0.86 -16.82 -0.68 2.95e-46 Oral cavity cancer; CRC cis rs13382862 0.862 rs340595 chr2:20889714 A/G cg07755735 chr2:20870362 GDF7 -0.33 -5.93 -0.31 7.56e-9 Abdominal aortic aneurysm; CRC cis rs4853012 0.838 rs60964317 chr2:74343423 A/T cg05890377 chr2:74357713 NA 0.63 10.77 0.51 2.32e-23 Gestational age at birth (maternal effect); CRC trans rs875971 0.660 rs2191268 chr7:66110224 C/T cg26596863 chr20:5108292 PCNA;CDS2 -0.4 -6.05 -0.32 3.84e-9 Aortic root size; CRC trans rs2303319 0.504 rs62189054 chr2:162624654 C/G cg18122310 chr12:50236657 BCDIN3D -0.73 -6.35 -0.33 7.23e-10 Cognitive function; CRC cis rs9467711 0.606 rs72841536 chr6:26378288 T/A cg12315302 chr6:26189340 HIST1H4D 0.7 5.65 0.3 3.42e-8 Autism spectrum disorder or schizophrenia; CRC cis rs9733 0.791 rs11204693 chr1:150647987 C/T cg17724175 chr1:150552817 MCL1 -0.45 -7.07 -0.36 9.09e-12 Tonsillectomy; CRC cis rs67311347 1.000 rs4973898 chr3:40459532 A/G cg09455208 chr3:40491958 NA -0.41 -8.25 -0.41 3.92e-15 Renal cell carcinoma; CRC cis rs9660992 0.762 rs1668871 chr1:205237137 T/C cg21643547 chr1:205240462 TMCC2 -0.46 -7.65 -0.39 2.19e-13 Mean corpuscular volume;Mean platelet volume; CRC cis rs806215 1.000 rs698406 chr7:127255285 C/G cg25922125 chr7:127225783 GCC1 0.63 6.69 0.35 9.71e-11 Type 2 diabetes; CRC cis rs1448094 0.520 rs12304244 chr12:86272823 C/T cg00310523 chr12:86230176 RASSF9 0.36 5.93 0.31 7.78e-9 Major depressive disorder; CRC trans rs1814175 0.715 rs1722007 chr11:49897319 T/C cg03929089 chr4:120376271 NA -0.94 -17.76 -0.7 5.67e-50 Height; CRC cis rs6089584 0.888 rs2892060 chr20:60617955 G/T cg23463467 chr20:60627584 TAF4 0.33 5.71 0.3 2.53e-8 Body mass index; CRC cis rs7647973 0.961 rs4955430 chr3:49378088 G/A cg20833759 chr3:49053208 WDR6;DALRD3 0.53 7.97 0.4 2.6e-14 Menarche (age at onset); CRC trans rs2727020 0.521 rs2088526 chr11:49531968 G/A cg15704280 chr7:45808275 SEPT13 0.76 10.02 0.48 8.55e-21 Coronary artery disease; CRC cis rs883565 0.654 rs7642737 chr3:39032469 T/C cg01426195 chr3:39028469 NA -0.52 -8.36 -0.42 1.79e-15 Handedness; CRC cis rs2635047 0.875 rs2251948 chr18:44681356 A/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.42 7.01 0.36 1.34e-11 Educational attainment; CRC cis rs7122539 0.646 rs9633985 chr11:66520608 A/T cg24851651 chr11:66362959 CCS 0.43 7.6 0.39 3.16e-13 HIV-1 susceptibility; CRC cis rs514406 0.929 rs555741 chr1:53318851 T/G cg24675658 chr1:53192096 ZYG11B -0.56 -8.49 -0.42 7.39e-16 Monocyte count; CRC cis rs6951245 0.872 rs75493422 chr7:1072890 C/T cg26224354 chr7:1096374 C7orf50;GPR146 -0.9 -11.23 -0.53 5.54e-25 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs7267979 0.816 rs6076358 chr20:25519403 G/T cg24626310 chr20:25276739 ABHD12;PYGB -0.33 -5.79 -0.3 1.68e-8 Liver enzyme levels (alkaline phosphatase); CRC cis rs71403859 0.568 rs12149489 chr16:71813780 G/T cg08717414 chr16:71523259 ZNF19 -0.92 -8.63 -0.43 2.66e-16 Post bronchodilator FEV1; CRC cis rs853679 0.550 rs1233704 chr6:28166923 A/G cg06470822 chr6:28175283 NA -1.02 -15.73 -0.66 5.53e-42 Depression; CRC cis rs7584330 0.554 rs7582964 chr2:238385766 C/T cg14458575 chr2:238380390 NA -0.59 -7.86 -0.4 5.36e-14 Prostate cancer; CRC cis rs798502 0.522 rs7790322 chr7:2830498 C/T cg19717773 chr7:2847554 GNA12 -0.48 -7.67 -0.39 1.94e-13 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Inflammatory bowel disease;Waist circumference adjusted for BMI in non-smokers;Ulcerative colitis;Waist circumference adjusted for body mass index;Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction); CRC cis rs12701220 0.901 rs12701710 chr7:1090396 A/G cg26240231 chr7:1148101 C7orf50 0.38 5.65 0.3 3.46e-8 Bronchopulmonary dysplasia; CRC cis rs67311347 1.000 rs12633431 chr3:40505740 C/T cg24209194 chr3:40518798 ZNF619 -0.42 -6.08 -0.32 3.29e-9 Renal cell carcinoma; CRC cis rs4713118 0.662 rs9357060 chr6:28024486 C/G cg25164649 chr6:28176230 NA 0.66 8.76 0.43 1.08e-16 Parkinson's disease; CRC trans rs4768236 0.808 rs4768224 chr12:40661403 A/T cg00973677 chr7:136553595 CHRM2 0.3 6.23 0.32 1.42e-9 Crohn's disease;Inflammatory bowel disease; CRC cis rs1799949 1.000 rs8176296 chr17:41203591 T/C cg05368731 chr17:41323189 NBR1 0.68 10.3 0.49 9.6e-22 Menopause (age at onset); CRC cis rs1669338 0.588 rs3804783 chr3:3184442 C/T cg16797762 chr3:3221439 CRBN -0.6 -5.7 -0.3 2.64e-8 White matter integrity; CRC cis rs1656402 1.000 rs1190455 chr2:233435153 A/G cg03852847 chr2:233439513 NA -0.44 -7.5 -0.38 6.14e-13 Non-small cell lung cancer (survival); CRC cis rs11864453 0.612 rs12708925 chr16:72122706 A/T cg23815491 chr16:72088622 HP 0.51 7.65 0.39 2.17e-13 Fibrinogen levels; CRC cis rs6665290 0.839 rs6699400 chr1:227190497 A/G cg10327440 chr1:227177885 CDC42BPA -1.04 -23.51 -0.79 2.15e-72 Myeloid white cell count; CRC cis rs6933660 0.745 rs6557138 chr6:151732017 C/T cg14262678 chr6:151773367 RMND1;C6orf211 0.5 8.15 0.41 7.78e-15 Menarche (age at onset); CRC cis rs4713118 0.662 rs9380045 chr6:28025279 A/G cg06470822 chr6:28175283 NA 0.95 13.58 0.6 1.14e-33 Parkinson's disease; CRC cis rs7762018 0.891 rs3088346 chr6:170149793 T/C cg17545662 chr6:170176663 C6orf70 0.57 6.4 0.33 5.21e-10 Thiazide-induced adverse metabolic effects in hypertensive patients; CRC cis rs9322193 0.962 rs11155685 chr6:150102785 A/C cg05861140 chr6:150128134 PCMT1 -0.43 -7.05 -0.36 1.03e-11 Lung cancer; CRC trans rs4276421 0.837 rs7727890 chr5:45478771 G/A cg04793272 chr11:119020941 ABCG4 -0.39 -6.53 -0.34 2.5e-10 P wave duration; CRC cis rs4654899 0.785 rs12070677 chr1:21337322 A/G cg02927042 chr1:21476669 EIF4G3 -0.4 -6.43 -0.33 4.52e-10 Superior frontal gyrus grey matter volume; CRC cis rs6424115 0.737 rs10917430 chr1:24170458 C/T cg15997130 chr1:24165203 NA -0.65 -8.49 -0.42 7.09e-16 Immature fraction of reticulocytes; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg06843320 chr6:27791727 HIST1H4J 0.45 6.33 0.33 8.18e-10 Response to antipsychotic treatment; CRC cis rs4237845 0.562 rs7133278 chr12:58336066 C/A cg02175503 chr12:58329896 NA 0.76 11.84 0.55 3.43e-27 Intelligence (multi-trait analysis); CRC cis rs2408955 0.521 rs10875749 chr12:48531917 T/A cg15465823 chr12:48382534 COL2A1 -0.38 -6.3 -0.33 9.29e-10 Glycated hemoglobin levels; CRC cis rs11122272 0.735 rs2491404 chr1:231512127 C/T cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.53 -7.99 -0.4 2.35e-14 Hemoglobin concentration; CRC cis rs9858542 1.000 rs13085791 chr3:49721798 C/A cg07274523 chr3:49395745 GPX1 0.46 5.93 0.31 7.68e-9 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC trans rs10504390 0.656 rs76624481 chr8:66551779 C/T cg26403416 chr21:43771339 TFF2 0.59 6.13 0.32 2.49e-9 IgG glycosylation; CRC cis rs12142240 0.698 rs72677594 chr1:46824371 A/C cg00530320 chr1:46809349 NSUN4 0.59 8.03 0.41 1.69e-14 Menopause (age at onset); CRC cis rs6543140 0.964 rs6734203 chr2:103080066 G/C cg03938978 chr2:103052716 IL18RAP 0.41 6.53 0.34 2.51e-10 Blood protein levels; CRC cis rs11645898 0.687 rs11075919 chr16:72106906 T/C cg14768367 chr16:72042858 DHODH -0.49 -5.71 -0.3 2.56e-8 Blood protein levels; CRC cis rs7267979 0.816 rs409853 chr20:25506067 T/C cg24626310 chr20:25276739 ABHD12;PYGB 0.33 5.75 0.3 2.01e-8 Liver enzyme levels (alkaline phosphatase); CRC cis rs4888262 0.514 rs8048239 chr16:74578317 A/T cg01733217 chr16:74700730 RFWD3 0.74 11.13 0.52 1.27e-24 Testicular germ cell tumor; CRC trans rs7615952 0.673 rs9821905 chr3:125620850 A/G cg07211511 chr3:129823064 LOC729375 1.08 12.7 0.57 2.48e-30 Blood pressure (smoking interaction); CRC cis rs651907 0.557 rs34181125 chr3:101490278 A/G cg12386194 chr3:101231763 SENP7 0.46 6.73 0.35 7.73e-11 Colorectal cancer; CRC cis rs4713118 0.629 rs203888 chr6:28021589 C/T cg12172441 chr6:28176163 NA 0.55 7.43 0.38 9.48e-13 Parkinson's disease; CRC cis rs7739232 0.920 rs77374381 chr6:53530662 A/G cg15658676 chr6:53530538 KLHL31 -0.76 -5.91 -0.31 8.68e-9 Hip circumference adjusted for BMI; CRC cis rs10461617 0.617 rs1423623 chr5:56065575 A/G cg24531977 chr5:56204891 C5orf35 0.46 6.34 0.33 7.42e-10 Type 2 diabetes; CRC cis rs10751667 0.621 rs10794353 chr11:948740 A/G cg23136738 chr11:925521 AP2A2 -0.4 -6.56 -0.34 2.04e-10 Alzheimer's disease (late onset); CRC cis rs67340775 0.541 rs200975 chr6:27855625 G/T cg02683197 chr6:28174875 NA 0.68 6.72 0.35 8.24e-11 Lung cancer in ever smokers; CRC cis rs9926296 0.712 rs258330 chr16:89729574 T/G cg03605463 chr16:89740564 NA 0.61 9.59 0.47 2.36e-19 Vitiligo; CRC cis rs995000 0.965 rs1168046 chr1:62983693 A/C cg19896129 chr1:63156450 NA -0.44 -6.91 -0.36 2.57e-11 Triglyceride levels; CRC cis rs12908161 0.920 rs35738019 chr15:85280210 T/C cg11189052 chr15:85197271 WDR73 0.57 8.22 0.41 4.83e-15 Schizophrenia; CRC cis rs2739330 0.828 rs5751770 chr22:24252842 A/G cg04234412 chr22:24373322 LOC391322 -0.7 -11.23 -0.53 5.51e-25 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs9393692 0.557 rs62394768 chr6:26326033 C/T cg00631329 chr6:26305371 NA -0.53 -8.79 -0.44 8.19e-17 Educational attainment; CRC cis rs6495122 0.501 rs6495144 chr15:75343438 T/C cg17294928 chr15:75287854 SCAMP5 -0.43 -6.36 -0.33 6.67e-10 Caffeine consumption;Diastolic blood pressure;Coffee consumption; CRC cis rs6964587 0.732 rs12539523 chr7:91710836 G/A cg17063962 chr7:91808500 NA 0.75 12.26 0.56 1.03e-28 Breast cancer; CRC cis rs6831352 0.918 rs13113166 chr4:100050528 A/G cg12011299 chr4:100065546 ADH4 -0.49 -9.27 -0.45 2.61e-18 Alcohol dependence; CRC cis rs35306767 0.953 rs11253520 chr10:975961 C/G cg26597838 chr10:835615 NA -0.54 -7.55 -0.38 4.43e-13 Eosinophil percentage of granulocytes; CRC cis rs10256972 0.552 rs2960830 chr7:1200641 T/C cg16145915 chr7:1198662 ZFAND2A -0.53 -11.4 -0.53 1.39e-25 Longevity;Endometriosis; CRC cis rs981844 0.714 rs6822142 chr4:154683524 C/T cg10279832 chr4:154682576 RNF175 0.38 5.79 0.3 1.65e-8 Response to statins (LDL cholesterol change); CRC cis rs950776 0.518 rs12916999 chr15:78826912 C/T cg06917634 chr15:78832804 PSMA4 0.66 10.42 0.5 3.55e-22 Sudden cardiac arrest; CRC cis rs2996428 0.561 rs2275833 chr1:3745721 C/T cg13057898 chr1:3703894 LRRC47 0.57 7.69 0.39 1.69e-13 Red cell distribution width; CRC cis rs9322193 0.884 rs9688699 chr6:150054816 A/G cg07701084 chr6:150067640 NUP43 0.57 8.27 0.41 3.31e-15 Lung cancer; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg00449941 chr17:26926011 SPAG5 0.42 6.22 0.32 1.5e-9 Intelligence (multi-trait analysis); CRC cis rs7666738 0.791 rs1896155 chr4:99020948 C/A cg05340658 chr4:99064831 C4orf37 0.61 9.51 0.46 4.05e-19 Colonoscopy-negative controls vs population controls; CRC cis rs9811920 0.555 rs68092024 chr3:99691522 C/T cg07805332 chr3:99536008 MIR548G;C3orf26 0.38 5.69 0.3 2.79e-8 Axial length; CRC cis rs1223397 0.651 rs488297 chr6:13300496 C/T cg07912922 chr6:13274314 PHACTR1 0.36 5.61 0.3 4.19e-8 Blood pressure; CRC cis rs2836950 0.545 rs1888489 chr21:40533164 T/C cg11890956 chr21:40555474 PSMG1 -0.62 -9.21 -0.45 3.85e-18 Menarche (age at onset); CRC cis rs7727544 1.000 rs10076701 chr5:131596419 A/G cg09877947 chr5:131593287 PDLIM4 0.4 7.65 0.39 2.28e-13 Blood metabolite levels; CRC cis rs3015497 0.789 rs8003372 chr14:51102351 G/A cg09863266 chr14:51125203 SAV1 -0.33 -6.32 -0.33 8.75e-10 Mean platelet volume; CRC trans rs561341 1.000 rs521919 chr17:30298039 G/T cg20587970 chr11:113659929 NA -1.15 -16.84 -0.68 2.44e-46 Hip circumference adjusted for BMI; CRC cis rs7914558 0.933 rs2066323 chr10:104871361 A/G cg15744005 chr10:104629667 AS3MT -0.34 -7.31 -0.37 2.1e-12 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs7927771 0.690 rs35496532 chr11:47450338 C/T cg18512352 chr11:47633146 NA -0.4 -7.75 -0.39 1.18e-13 Subjective well-being; CRC cis rs9916302 0.904 rs9898773 chr17:37532507 C/G cg00129232 chr17:37814104 STARD3 0.53 7.92 0.4 3.58e-14 Glomerular filtration rate (creatinine); CRC cis rs1580019 0.587 rs34488151 chr7:32548146 A/G cg07520158 chr7:32535189 LSM5;AVL9 0.55 8.08 0.41 1.25e-14 Cognitive ability; CRC cis rs597539 0.652 rs584108 chr11:68630282 A/T cg21963583 chr11:68658836 MRPL21 -0.6 -11.03 -0.52 2.89e-24 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs992157 0.764 rs13020391 chr2:219184436 C/T cg00012203 chr2:219082015 ARPC2 -0.44 -6.14 -0.32 2.34e-9 Colorectal cancer; CRC trans rs2228479 0.867 rs11642451 chr16:89958127 T/C cg21302420 chr1:112162376 RAP1A 0.81 7.43 0.38 9.4e-13 Skin colour saturation; CRC cis rs12477438 0.765 rs4374423 chr2:99662348 G/A cg26064155 chr2:99771622 LIPT1;TSGA10 -0.63 -8.55 -0.43 4.61e-16 Chronic sinus infection; CRC trans rs2303319 0.504 rs12473497 chr2:162433766 T/C cg00039960 chr17:7142925 PHF23 -0.73 -6.0 -0.31 5.26e-9 Cognitive function; CRC cis rs694739 0.595 rs11542299 chr11:64138805 T/C cg23796481 chr11:64053134 BAD;GPR137 0.48 6.75 0.35 6.84e-11 Alopecia areata;Crohn's disease;Psoriasis vulgaris; CRC cis rs514406 0.825 rs3863643 chr1:53224577 C/T cg27535305 chr1:53392650 SCP2 0.38 6.97 0.36 1.77e-11 Monocyte count; CRC cis rs561341 0.714 rs474455 chr17:30312465 A/T cg00745463 chr17:30367425 LRRC37B -0.74 -9.01 -0.44 1.69e-17 Hip circumference adjusted for BMI; CRC cis rs1008375 1.000 rs7661631 chr4:17679751 T/C cg16339924 chr4:17578868 LAP3 -0.54 -7.11 -0.36 7.39e-12 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs4665809 0.556 rs10221814 chr2:26442759 C/T cg22920501 chr2:26401640 FAM59B -0.85 -12.62 -0.57 4.71e-30 Gut microbiome composition (summer); CRC cis rs9368481 0.761 rs9357030 chr6:26985026 G/T cg05192639 chr6:26864778 GUSBL1 -0.34 -5.93 -0.31 7.53e-9 Autism spectrum disorder or schizophrenia; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg02897623 chr16:89626761 RPL13;SNORD68 0.42 6.01 0.31 4.89e-9 Intelligence (multi-trait analysis); CRC cis rs910316 0.967 rs2024653 chr14:75595154 G/A cg11812906 chr14:75593930 NEK9 0.61 9.56 0.47 2.91e-19 Height; CRC cis rs6502050 0.835 rs11077981 chr17:80147243 C/T cg19223190 chr17:80058835 NA 0.39 6.21 0.32 1.62e-9 Life satisfaction; CRC cis rs853679 0.517 rs11552219 chr6:28126834 C/T cg12273811 chr6:28175739 NA 0.73 9.16 0.45 5.8e-18 Depression; CRC cis rs7647973 0.961 rs6778080 chr3:49317338 C/T cg07636037 chr3:49044803 WDR6 -0.57 -6.97 -0.36 1.74e-11 Menarche (age at onset); CRC cis rs3796352 0.881 rs35385050 chr3:52997945 C/A cg06204229 chr3:52865917 ITIH4 0.5 5.7 0.3 2.67e-8 Immune reponse to smallpox (secreted IL-2); CRC cis rs12681288 0.712 rs2600488 chr8:1021266 A/C cg15309053 chr8:964076 NA 0.35 6.09 0.32 3.22e-9 Schizophrenia; CRC cis rs6968419 0.755 rs73452247 chr7:115893897 T/C cg02561103 chr7:115862891 TES -0.43 -6.47 -0.34 3.48e-10 Intraocular pressure; CRC cis rs11971779 0.688 rs8137 chr7:139104461 A/C cg23387468 chr7:139079360 LUC7L2 -0.4 -6.96 -0.36 1.79e-11 Diisocyanate-induced asthma; CRC trans rs8035957 1.000 rs4924273 chr15:38846738 C/G cg06700871 chr2:84686330 SUCLG1 -0.51 -6.02 -0.31 4.6e-9 Type 1 diabetes; CRC cis rs2404602 0.655 rs4886824 chr15:76969256 A/G cg22467129 chr15:76604101 ETFA -0.39 -6.53 -0.34 2.5e-10 Blood metabolite levels; CRC cis rs972578 0.967 rs738391 chr22:43339878 A/G cg01576275 chr22:43409880 NA -0.45 -7.24 -0.37 3.23e-12 Mean platelet volume; CRC cis rs4731207 0.596 rs7786384 chr7:124577270 C/T cg23710748 chr7:124431027 NA -0.39 -6.12 -0.32 2.67e-9 Cutaneous malignant melanoma; CRC cis rs9322193 0.884 rs9689702 chr6:150061856 G/A cg07701084 chr6:150067640 NUP43 0.61 9.12 0.45 7.81e-18 Lung cancer; CRC cis rs2408955 0.504 rs11168441 chr12:48576054 G/A cg00601486 chr12:48723148 H1FNT 0.33 5.98 0.31 5.8e-9 Glycated hemoglobin levels; CRC cis rs514406 0.825 rs497535 chr1:53284677 A/G cg25767906 chr1:53392781 SCP2 0.47 7.49 0.38 6.24e-13 Monocyte count; CRC cis rs2197308 0.623 rs1672426 chr12:38118671 C/T cg26384229 chr12:38710491 ALG10B -0.56 -8.15 -0.41 7.66e-15 Morning vs. evening chronotype; CRC cis rs9326248 0.954 rs521171 chr11:117064693 C/G cg10398005 chr11:117014888 PAFAH1B2 -0.4 -5.72 -0.3 2.41e-8 Blood protein levels; CRC cis rs11997175 0.646 rs10954936 chr8:33686165 C/T ch.8.33884649F chr8:33765107 NA 0.43 6.12 0.32 2.67e-9 Body mass index; CRC cis rs9372498 0.536 rs55697388 chr6:118891544 C/T cg24463073 chr6:118973353 C6orf204 0.52 6.83 0.35 4.1e-11 Diastolic blood pressure; CRC cis rs2415984 0.622 rs61993303 chr14:46949716 G/C cg14871534 chr14:47121158 RPL10L -0.45 -6.42 -0.33 4.84e-10 Number of children ever born; CRC cis rs3889199 1.000 rs12739770 chr1:59655744 A/G cg25881383 chr1:59680599 NA -0.36 -5.84 -0.31 1.23e-8 Pulse pressure; CRC cis rs34638657 0.500 rs7405197 chr16:82169833 C/A cg07918374 chr16:82182319 MPHOSPH6 0.4 5.64 0.3 3.65e-8 Lung adenocarcinoma; CRC cis rs4660306 1.000 rs7534467 chr1:45988691 G/A cg03123370 chr1:45965343 CCDC163P;MMACHC -0.55 -7.81 -0.4 7.94e-14 Homocysteine levels; CRC cis rs10504229 1.000 rs57261109 chr8:58172152 C/T cg05313129 chr8:58192883 C8orf71 -0.47 -6.99 -0.36 1.49e-11 Developmental language disorder (linguistic errors); CRC cis rs11226613 0.547 rs1792762 chr11:104960976 C/T cg04181079 chr11:104896587 CASP1 0.42 5.7 0.3 2.7e-8 Bronchopulmonary dysplasia; CRC cis rs6456156 0.792 rs2039321 chr6:167516299 C/T cg07741184 chr6:167504864 NA 0.48 8.36 0.42 1.84e-15 Primary biliary cholangitis; CRC trans rs194045 0.609 rs252344 chr16:29184882 G/A cg17334114 chr3:133646504 NA 0.47 6.24 0.33 1.34e-9 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs7259376 0.936 rs1865075 chr19:22554854 T/C cg02657401 chr19:22469223 NA -0.33 -7.15 -0.37 5.7e-12 Menopause (age at onset); CRC cis rs709400 0.633 rs1951391 chr14:103898313 T/C cg12935359 chr14:103987150 CKB -0.49 -7.99 -0.4 2.23e-14 Body mass index; CRC cis rs911119 0.818 rs12625182 chr20:23604023 G/T cg16589663 chr20:23618590 CST3 0.45 6.35 0.33 7.19e-10 Chronic kidney disease; CRC cis rs13108904 0.934 rs13115173 chr4:1316824 T/C cg21620606 chr4:1342894 KIAA1530 0.34 5.62 0.3 4.15e-8 Obesity-related traits; CRC cis rs1448094 0.512 rs7953318 chr12:86245929 G/A cg25456477 chr12:86230367 RASSF9 0.34 5.99 0.31 5.54e-9 Major depressive disorder; CRC cis rs7615952 0.688 rs12485622 chr3:125710739 T/C cg05084668 chr3:125655381 ALG1L -0.47 -6.86 -0.35 3.4e-11 Blood pressure (smoking interaction); CRC cis rs9287719 0.967 rs7600587 chr2:10739851 A/G cg00105475 chr2:10696890 NA 0.45 7.3 0.37 2.19e-12 Prostate cancer; CRC cis rs7647973 1.000 rs56127630 chr3:49438036 C/G cg07636037 chr3:49044803 WDR6 -0.65 -7.76 -0.39 1.06e-13 Menarche (age at onset); CRC cis rs2832191 0.636 rs8131283 chr21:30516796 A/G cg24692254 chr21:30365293 RNF160 -0.59 -8.59 -0.43 3.44e-16 Dental caries; CRC cis rs11955398 0.625 rs10805370 chr5:59984244 A/T cg02684056 chr5:59996105 DEPDC1B 0.4 5.85 0.31 1.21e-8 Intelligence (multi-trait analysis); CRC cis rs9549367 0.789 rs2287251 chr13:113889499 A/G cg00898013 chr13:113819073 PROZ -0.46 -6.81 -0.35 4.63e-11 Platelet distribution width; CRC cis rs262150 0.851 rs2730249 chr7:158767628 A/G cg07130601 chr7:158766826 NA -0.4 -5.83 -0.31 1.3e-8 Facial morphology (factor 20); CRC cis rs9916302 0.784 rs34473775 chr17:37396201 G/T cg00129232 chr17:37814104 STARD3 -0.54 -7.98 -0.4 2.4e-14 Glomerular filtration rate (creatinine); CRC cis rs7772486 0.754 rs9386134 chr6:146145508 G/A cg13319975 chr6:146136371 FBXO30 -0.49 -7.19 -0.37 4.47e-12 Lobe attachment (rater-scored or self-reported); CRC cis rs4862750 0.832 rs10007858 chr4:187877492 A/G cg22105103 chr4:187893119 NA 0.64 11.84 0.55 3.53e-27 Lobe attachment (rater-scored or self-reported); CRC cis rs2228479 0.850 rs1800344 chr16:89816367 T/G cg06558623 chr16:89946397 TCF25 1.15 10.8 0.51 1.85e-23 Skin colour saturation; CRC cis rs3849570 0.961 rs7620240 chr3:81762787 G/T cg07356753 chr3:81810745 GBE1 -0.74 -11.08 -0.52 1.87e-24 Waist circumference;Body mass index; CRC cis rs1552244 0.882 rs13089863 chr3:10032259 G/T cg16606324 chr3:10149918 C3orf24 -0.58 -7.2 -0.37 4.02e-12 Alzheimer's disease; CRC cis rs898097 0.625 rs7406464 chr17:80891460 A/G cg03160526 chr17:80928410 B3GNTL1 -0.49 -8.08 -0.41 1.25e-14 Breast cancer; CRC trans rs10983614 1.000 rs7867776 chr9:120072627 A/G cg24201716 chr10:115933917 C10orf118;MIR2110 0.45 6.24 0.33 1.37e-9 Survival in pancreatic cancer; CRC cis rs10256972 0.552 rs2960830 chr7:1200641 T/C cg27094323 chr7:1216898 NA -0.4 -6.61 -0.34 1.52e-10 Longevity;Endometriosis; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg04132851 chr1:85155548 SSX2IP 0.44 6.19 0.32 1.8e-9 Response to antipsychotic treatment; CRC cis rs55675132 0.510 rs12120851 chr1:115262845 T/C cg12756093 chr1:115239321 AMPD1 0.52 6.26 0.33 1.23e-9 Schizophrenia; CRC cis rs801193 0.805 rs12532355 chr7:66070584 C/G cg11764359 chr7:65958608 NA -0.5 -7.63 -0.39 2.49e-13 Aortic root size; CRC cis rs3540 0.960 rs10083661 chr15:91022339 G/A cg04176472 chr15:90893244 GABARAPL3 0.36 6.26 0.33 1.17e-9 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; CRC trans rs877282 0.733 rs7092976 chr10:756358 G/A cg22713356 chr15:30763199 NA 1.19 13.88 0.61 8.17e-35 Uric acid levels; CRC cis rs523522 0.924 rs11065150 chr12:120958875 T/G cg27279351 chr12:120934652 DYNLL1 0.78 11.48 0.53 7.05e-26 High light scatter reticulocyte count; CRC cis rs853679 0.517 rs55747925 chr6:28044337 T/C cg15786705 chr6:28176104 NA 0.73 9.31 0.46 1.85e-18 Depression; CRC cis rs910316 0.763 rs12588981 chr14:75460561 A/G cg03030879 chr14:75389066 RPS6KL1 -0.42 -6.41 -0.33 5.03e-10 Height; CRC cis rs7216064 1.000 rs7224923 chr17:65842265 T/G cg12091567 chr17:66097778 LOC651250 -0.68 -7.87 -0.4 5.31e-14 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CRC cis rs12580194 0.593 rs11171435 chr12:55758053 T/C cg19537932 chr12:55886519 OR6C68 -0.67 -8.84 -0.44 6.1e-17 Cancer; CRC cis rs9549328 0.616 rs35086993 chr13:113617305 G/A cg17524180 chr13:113633600 MCF2L 0.52 9.51 0.46 4.24e-19 Systolic blood pressure; CRC cis rs853679 0.517 rs2275508 chr6:28094731 T/C cg12172441 chr6:28176163 NA 0.6 7.19 0.37 4.46e-12 Depression; CRC cis rs9900062 1.000 rs11871616 chr17:62737602 C/T cg02598441 chr17:62777298 LOC146880 -0.57 -7.69 -0.39 1.69e-13 QT interval; CRC cis rs13108904 0.901 rs2293634 chr4:1291711 T/G cg16405210 chr4:1374714 KIAA1530 -0.46 -6.67 -0.34 1.11e-10 Obesity-related traits; CRC cis rs12908161 0.853 rs12912342 chr15:85248216 T/C cg11189052 chr15:85197271 WDR73 0.53 7.58 0.39 3.57e-13 Schizophrenia; CRC cis rs8078723 0.763 rs4433838 chr17:38143532 C/T cg17344932 chr17:38183730 MED24;SNORD124 0.48 7.89 0.4 4.43e-14 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); CRC cis rs6502050 0.805 rs7503095 chr17:80107354 G/A cg09264619 chr17:80180166 NA -0.34 -5.81 -0.3 1.5e-8 Life satisfaction; CRC cis rs2276314 0.762 rs3826600 chr18:33609053 A/G cg19628046 chr18:33552617 C18orf21 0.49 6.58 0.34 1.81e-10 Endometriosis;Drug-induced torsades de pointes; CRC cis rs35306767 0.855 rs34251037 chr10:867884 C/T cg20503657 chr10:835505 NA 1.23 15.05 0.64 2.68e-39 Eosinophil percentage of granulocytes; CRC trans rs7395662 0.759 rs11529442 chr11:48819986 T/C cg21153622 chr11:89784906 NA 0.44 7.01 0.36 1.34e-11 HDL cholesterol; CRC cis rs798554 0.757 rs960273 chr7:2857876 T/C cg17321639 chr7:2759063 NA -0.51 -6.79 -0.35 5.18e-11 Height; CRC cis rs7086627 0.515 rs7078254 chr10:82212193 C/T cg00277334 chr10:82204260 NA -0.83 -16.58 -0.67 2.53e-45 Post bronchodilator FEV1; CRC cis rs9902453 0.817 rs12941382 chr17:28410124 T/C cg26525008 chr17:28256777 EFCAB5;SSH2 -0.73 -11.95 -0.55 1.37e-27 Coffee consumption (cups per day); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg23888375 chr2:203776317 ALS2CR8;WDR12 0.41 6.31 0.33 9.04e-10 Liver disease severity in Alagille syndrome; CRC cis rs35883536 0.647 rs10875328 chr1:101169328 C/T cg06223162 chr1:101003688 GPR88 -0.35 -5.95 -0.31 7.05e-9 Monocyte count; CRC cis rs123509 0.913 rs121993 chr3:42776601 T/C cg12982090 chr3:42733453 KBTBD5 0.55 7.1 0.36 7.9e-12 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs4964805 1.000 rs12228207 chr12:104196734 T/C cg02344784 chr12:104178138 NT5DC3 0.5 7.0 0.36 1.41e-11 Attention deficit hyperactivity disorder; CRC trans rs1814175 0.817 rs6486044 chr11:49982718 C/T cg11707556 chr5:10655725 ANKRD33B -0.42 -8.01 -0.4 2.02e-14 Height; CRC cis rs3749237 0.595 rs11130192 chr3:49467206 C/G cg02487422 chr3:49467188 NICN1 0.43 6.87 0.35 3.18e-11 Resting heart rate; CRC cis rs3796352 1.000 rs13069006 chr3:52973305 G/C cg07884673 chr3:53033167 SFMBT1 0.76 6.1 0.32 2.92e-9 Immune reponse to smallpox (secreted IL-2); CRC cis rs10751667 0.643 rs10751666 chr11:941933 C/T cg23136738 chr11:925521 AP2A2 -0.42 -6.98 -0.36 1.65e-11 Alzheimer's disease (late onset); CRC cis rs9640161 0.830 rs76741564 chr7:150059529 A/T cg13722127 chr7:150037890 RARRES2 0.39 5.69 0.3 2.86e-8 Blood protein levels;Circulating chemerin levels; CRC cis rs763014 0.932 rs2269559 chr16:682297 T/C cg04497992 chr16:616212 NHLRC4 0.42 6.57 0.34 2e-10 Height; CRC cis rs2386661 0.826 rs4749922 chr10:5680689 A/G cg26603656 chr10:5671107 NA 0.53 8.9 0.44 3.87e-17 Breast cancer; CRC cis rs11190604 1.000 rs12358187 chr10:102284449 C/G cg16342193 chr10:102329863 NA -0.37 -6.0 -0.31 5.28e-9 Palmitoleic acid (16:1n-7) levels; CRC cis rs66887589 0.616 rs1052633 chr4:120215314 A/G cg09307838 chr4:120376055 NA 0.55 8.44 0.42 1e-15 Diastolic blood pressure; CRC cis rs367943 1.000 rs348944 chr5:112822925 C/T cg12552261 chr5:112820674 MCC -0.49 -7.52 -0.38 5.23e-13 Type 2 diabetes; CRC cis rs10256972 0.591 rs6950319 chr7:1161324 A/G cg18402987 chr7:1209562 NA 0.48 6.93 0.36 2.19e-11 Longevity;Endometriosis; CRC cis rs7614311 0.731 rs73130534 chr3:63859813 A/G cg22134162 chr3:63841271 THOC7 -0.55 -5.72 -0.3 2.4e-8 Lung function (FVC);Lung function (FEV1); CRC cis rs947211 0.948 rs863725 chr1:205751196 C/T cg14159672 chr1:205819179 PM20D1 0.42 5.7 0.3 2.65e-8 Parkinson's disease; CRC trans rs9858542 0.953 rs34363169 chr3:49537712 G/A cg21665057 chr3:196295764 WDR53;FBXO45 -0.65 -8.86 -0.44 5.12e-17 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs9329289 0.510 rs10903785 chr10:2550063 C/T cg15501526 chr10:2543763 NA 0.51 9.29 0.46 2.13e-18 Age-related hearing impairment; CRC cis rs17376456 0.569 rs2045020 chr5:93224466 T/C cg09848695 chr5:92956644 FAM172A;MIR2277 -0.51 -5.76 -0.3 1.93e-8 Diabetic retinopathy; CRC cis rs4588572 0.601 rs6867673 chr5:77779125 A/G cg11547950 chr5:77652471 NA -0.54 -7.31 -0.37 2.04e-12 Triglycerides; CRC trans rs7615952 0.546 rs2922171 chr3:125343193 C/T cg02560186 chr11:3602584 NA -0.56 -6.98 -0.36 1.63e-11 Blood pressure (smoking interaction); CRC cis rs2070488 0.965 rs4679060 chr3:38536261 T/C cg01465620 chr3:38496096 LOC100128640;ACVR2B -0.91 -17.15 -0.69 1.51e-47 Electrocardiographic conduction measures; CRC cis rs7618915 0.547 rs6976 chr3:52728804 C/T cg05573699 chr3:52720067 GNL3;PBRM1 -0.45 -6.31 -0.33 9.2e-10 Bipolar disorder; CRC cis rs2737618 0.674 rs2821332 chr1:200085714 A/T cg21825944 chr1:200113062 NR5A2 -0.51 -7.51 -0.38 5.79e-13 Uric acid levels; CRC cis rs12681287 0.640 rs13258126 chr8:87453378 G/T cg27223183 chr8:87520930 FAM82B -0.52 -7.44 -0.38 8.7e-13 Caudate activity during reward; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg02902865 chr1:12679132 DHRS3 0.52 6.83 0.35 4.14e-11 Thyroid stimulating hormone; CRC cis rs875971 0.862 rs11765791 chr7:65936574 A/G cg11764359 chr7:65958608 NA 0.57 8.33 0.42 2.16e-15 Aortic root size; CRC cis rs6502050 0.835 rs6502068 chr17:80112223 C/T cg02741985 chr17:80059408 CCDC57 0.43 7.05 0.36 1.04e-11 Life satisfaction; CRC cis rs8114671 0.562 rs4911161 chr20:33402231 C/T cg24642439 chr20:33292090 TP53INP2 0.37 5.81 0.3 1.51e-8 Height; CRC cis rs6504622 0.818 rs9303532 chr17:45034002 C/T cg16759221 chr17:45003025 GOSR2 0.5 7.55 0.38 4.38e-13 Orofacial clefts; CRC cis rs4509693 0.941 rs7914169 chr10:102495725 A/G cg26596964 chr10:102495354 NA -0.41 -5.65 -0.3 3.4e-8 Alzheimer's disease; CRC cis rs2303745 0.841 rs10409801 chr19:17407415 A/G cg02221750 chr19:17393354 ANKLE1 -0.48 -6.51 -0.34 2.83e-10 Systemic lupus erythematosus; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg04296434 chr20:48769996 TMEM189;TMEM189-UBE2V1 0.44 6.41 0.33 4.9e-10 Intelligence (multi-trait analysis); CRC cis rs17095355 0.786 rs61624875 chr10:111722489 T/C cg00817464 chr10:111662876 XPNPEP1 -0.6 -8.36 -0.42 1.74e-15 Biliary atresia; CRC cis rs2032447 0.933 rs4401650 chr6:26035208 G/A cg27635394 chr6:26043820 HIST1H2BB 0.43 6.35 0.33 7.32e-10 Intelligence (multi-trait analysis); CRC cis rs780096 0.506 rs1647265 chr2:27692261 A/G cg21248554 chr2:27665150 KRTCAP3 -0.33 -7.82 -0.4 7.44e-14 Total body bone mineral density; CRC cis rs1552244 1.000 rs9845756 chr3:10067548 G/C cg02579736 chr3:10068473 FANCD2;CIDECP 0.96 12.65 0.57 3.81e-30 Alzheimer's disease; CRC cis rs870825 0.616 rs4386643 chr4:185624281 A/T cg04058563 chr4:185651563 MLF1IP 0.72 9.38 0.46 1.12e-18 Blood protein levels; CRC trans rs8073060 0.586 rs4796101 chr17:33998593 C/T cg19694781 chr19:47549865 TMEM160 -1.07 -15.14 -0.64 1.2e-39 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; CRC cis rs4780401 0.933 rs12926451 chr16:11819569 A/C cg01061890 chr16:11836724 TXNDC11 0.4 5.61 0.3 4.35e-8 Rheumatoid arthritis; CRC cis rs9747201 0.926 rs35131420 chr17:80103631 T/C cg09264619 chr17:80180166 NA 0.51 7.3 0.37 2.17e-12 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs6582630 0.555 rs2090785 chr12:38424342 G/A cg13010199 chr12:38710504 ALG10B 0.47 6.32 0.33 8.32e-10 Drug-induced liver injury (flucloxacillin); CRC cis rs8103278 0.507 rs8112282 chr19:46265029 C/T cg02376097 chr19:46275166 DMPK 0.36 5.79 0.3 1.66e-8 Coronary artery disease; CRC cis rs2952156 0.920 rs1476278 chr17:37836243 C/T cg11212589 chr17:38028394 ZPBP2 0.33 5.77 0.3 1.8e-8 Asthma; CRC cis rs1223397 0.651 rs2496145 chr6:13312293 C/T cg20827128 chr6:13274284 PHACTR1 -0.37 -5.7 -0.3 2.71e-8 Blood pressure; CRC cis rs736408 0.522 rs11130310 chr3:52674667 C/T cg18099408 chr3:52552593 STAB1 -0.46 -7.82 -0.4 7.16e-14 Bipolar disorder; CRC cis rs7113874 0.610 rs11041924 chr11:8463107 C/T cg20771178 chr11:8615675 STK33 -0.35 -5.78 -0.3 1.71e-8 Body mass index in physically active individuals;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs9303280 0.901 rs2313430 chr17:37929816 T/C cg11212589 chr17:38028394 ZPBP2 -0.44 -8.36 -0.42 1.76e-15 Self-reported allergy; CRC cis rs9443645 0.901 rs4147183 chr6:79557046 C/G cg09184832 chr6:79620586 NA -0.51 -9.72 -0.47 8.19e-20 Intelligence (multi-trait analysis); CRC cis rs9811920 0.809 rs6802817 chr3:99779264 A/G cg07805332 chr3:99536008 MIR548G;C3orf26 0.4 6.17 0.32 1.96e-9 Axial length; CRC cis rs11971779 0.680 rs6467840 chr7:139065401 A/T cg23387468 chr7:139079360 LUC7L2 0.41 7.04 0.36 1.14e-11 Diisocyanate-induced asthma; CRC cis rs10876993 0.928 rs2169988 chr12:58071165 G/A cg15848620 chr12:58087721 OS9 -0.6 -8.33 -0.42 2.17e-15 Celiac disease or Rheumatoid arthritis; CRC cis rs10752881 0.875 rs10752894 chr1:183050610 A/G ch.1.3577855R chr1:183094577 LAMC1 0.82 14.22 0.62 4.28e-36 Colorectal cancer; CRC cis rs57221529 0.766 rs17497684 chr5:558307 T/C cg09021430 chr5:549028 NA -0.72 -8.14 -0.41 8.04e-15 Lung disease severity in cystic fibrosis; CRC cis rs1555895 0.656 rs61831439 chr10:840244 A/G cg10556349 chr10:835070 NA -0.38 -7.2 -0.37 4.23e-12 Survival in rectal cancer; CRC cis rs2455601 0.638 rs3815991 chr11:9007669 A/G cg21881798 chr11:8931708 C11orf17;ST5 0.51 5.82 0.31 1.37e-8 Schizophrenia; CRC cis rs7917772 0.636 rs2253709 chr10:104542745 T/A cg04362960 chr10:104952993 NT5C2 -0.49 -6.34 -0.33 7.39e-10 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC cis rs13256369 0.851 rs11249890 chr8:8565245 G/T cg00074818 chr8:8560427 CLDN23 0.39 7.04 0.36 1.15e-11 Obesity-related traits; CRC cis rs910316 1.000 rs876403 chr14:75602834 A/T cg03030879 chr14:75389066 RPS6KL1 -0.47 -7.45 -0.38 8.29e-13 Height; CRC cis rs9611565 0.694 rs202641 chr22:41833116 C/T cg03806693 chr22:41940476 POLR3H 0.9 11.98 0.55 1.05e-27 Vitiligo; CRC cis rs2576037 0.526 rs658756 chr18:44431832 A/G cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.53 9.05 0.45 1.25e-17 Personality dimensions; CRC trans rs3733585 0.624 rs7376154 chr4:9952587 C/A cg26043149 chr18:55253948 FECH -0.5 -7.71 -0.39 1.51e-13 Cleft plate (environmental tobacco smoke interaction); CRC cis rs17270561 0.525 rs10484432 chr6:26008876 G/A cg17691542 chr6:26056736 HIST1H1C 0.99 12.3 0.56 7.43e-29 Iron status biomarkers; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg06635431 chr1:33283895 YARS;S100PBP 0.42 6.11 0.32 2.76e-9 Intelligence (multi-trait analysis); CRC cis rs2717559 0.542 rs2717586 chr8:143897882 C/T cg24046110 chr8:143859143 LYNX1 0.73 12.98 0.58 2.09e-31 Urinary tract infection frequency; CRC cis rs7224685 0.569 rs12947597 chr17:3999199 A/G cg11204139 chr17:3907470 NA -0.49 -6.2 -0.32 1.68e-9 Type 2 diabetes; CRC cis rs34375054 0.573 rs12581367 chr12:125654641 T/C cg06287003 chr12:125626642 AACS -0.58 -7.05 -0.36 1.04e-11 Post bronchodilator FEV1/FVC ratio; CRC cis rs6951245 1.000 rs74366004 chr7:1088630 A/C cg20603222 chr7:1096387 C7orf50;GPR146 -0.73 -8.49 -0.42 7.07e-16 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs10504229 0.636 rs72649133 chr8:58054681 G/A cg02290350 chr8:58132656 NA -0.61 -6.94 -0.36 2.1e-11 Developmental language disorder (linguistic errors); CRC cis rs11711311 0.955 rs34458493 chr3:113396473 C/T cg15478005 chr3:113465772 ATP6V1A;NAA50 0.43 5.79 0.3 1.68e-8 IgG glycosylation; CRC cis rs7647973 1.000 rs7648995 chr3:49438803 C/T cg07636037 chr3:49044803 WDR6 -0.65 -7.81 -0.4 7.8e-14 Menarche (age at onset); CRC cis rs7666738 0.830 rs13138920 chr4:99020786 A/G cg05340658 chr4:99064831 C4orf37 0.61 9.51 0.46 4.05e-19 Colonoscopy-negative controls vs population controls; CRC cis rs7589342 0.929 rs12053259 chr2:106428720 G/A cg16077055 chr2:106428750 NCK2 0.4 5.77 0.3 1.87e-8 Addiction; CRC cis rs6545883 1.000 rs6742276 chr2:61768745 G/A cg15711740 chr2:61764176 XPO1 -0.51 -7.03 -0.36 1.2e-11 Tuberculosis; CRC cis rs780096 0.506 rs2288155 chr2:27714526 T/C cg12000995 chr2:27665139 KRTCAP3 -0.32 -6.37 -0.33 6.46e-10 Total body bone mineral density; CRC cis rs473651 0.935 rs559579 chr2:239339501 G/C cg18131467 chr2:239335373 ASB1 0.87 14.08 0.61 1.47e-35 Multiple system atrophy; CRC cis rs2735413 0.918 rs36068555 chr16:78077082 G/A cg04733911 chr16:78082701 NA -0.45 -7.5 -0.38 6.09e-13 Systolic blood pressure (alcohol consumption interaction); CRC cis rs7208859 0.623 rs79607958 chr17:28934548 T/G cg19761014 chr17:28927070 LRRC37B2 0.59 5.88 0.31 1.02e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs9910055 0.530 rs11656758 chr17:42301541 A/G cg10896456 chr17:42255109 ASB16;C17orf65 0.34 5.94 0.31 7.16e-9 Total body bone mineral density; CRC cis rs2739330 0.828 rs5751770 chr22:24252842 A/G cg11905131 chr22:24372483 LOC391322 -0.71 -11.35 -0.53 1.97e-25 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs6912958 0.559 rs373646 chr6:88056896 A/G cg04972856 chr6:88032051 C6orf162;GJB7 0.31 5.92 0.31 7.98e-9 Monocyte percentage of white cells; CRC trans rs10021731 0.718 rs1870655 chr4:115412781 C/T cg25927708 chr2:119603813 EN1 -0.33 -6.01 -0.31 4.92e-9 Optic disc area; CRC trans rs116095464 0.558 rs11959126 chr5:283880 T/G cg00938859 chr5:1591904 SDHAP3 0.71 7.58 0.39 3.45e-13 Breast cancer; CRC cis rs7746199 0.668 rs7749305 chr6:27446566 T/C cg26587870 chr6:27730563 NA -0.67 -6.29 -0.33 1.04e-9 Gait speed in old age;Autism spectrum disorder or schizophrenia; CRC cis rs55788414 0.932 rs12102691 chr16:81181460 G/T cg06400318 chr16:81190750 PKD1L2 -0.58 -6.7 -0.35 9.27e-11 Left ventricular obstructive tract defect (maternal effect); CRC cis rs501120 0.584 rs7097076 chr10:44701352 C/A cg09554077 chr10:44749378 NA 0.69 7.87 0.4 5.01e-14 Coronary artery disease;Coronary heart disease; CRC cis rs1062746 0.711 rs8056833 chr16:87378388 G/C cg02258303 chr16:87377426 FBXO31 -0.65 -10.72 -0.51 3.29e-23 Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 2 peripheral neuropathy); CRC cis rs2739330 0.789 rs5760109 chr22:24252938 C/G cg04234412 chr22:24373322 LOC391322 -0.71 -11.37 -0.53 1.8e-25 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs4665809 0.590 rs35532350 chr2:26441605 T/C cg25036284 chr2:26402008 FAM59B -0.61 -7.76 -0.39 1.09e-13 Gut microbiome composition (summer); CRC cis rs6952808 1.000 rs6954521 chr7:1886865 C/A cg22963979 chr7:1858916 MAD1L1 -0.66 -10.09 -0.49 4.87e-21 Bipolar disorder and schizophrenia; CRC trans rs1005277 0.579 rs2505241 chr10:38442421 T/C cg27523141 chr10:43048294 ZNF37B 0.49 7.12 0.37 6.93e-12 Extrinsic epigenetic age acceleration; CRC cis rs597539 0.652 rs660614 chr11:68659488 G/A cg06112835 chr11:68658793 MRPL21 0.47 7.57 0.38 3.88e-13 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs17376456 0.877 rs9314100 chr5:93447394 T/C cg09848695 chr5:92956644 FAM172A;MIR2277 0.65 6.03 0.32 4.38e-9 Diabetic retinopathy; CRC cis rs13217239 0.646 rs12201393 chr6:26975690 C/A cg18867708 chr6:26865862 GUSBL1 0.38 5.82 0.31 1.39e-8 Schizophrenia; CRC cis rs4363385 0.818 rs423692 chr1:153005681 T/G cg25856811 chr1:152973957 SPRR3 -0.25 -6.99 -0.36 1.51e-11 Inflammatory skin disease; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg27118876 chr15:92397541 SLCO3A1 0.39 6.1 0.32 3.05e-9 Liver disease severity in Alagille syndrome; CRC cis rs644799 0.542 rs10831415 chr11:95466159 A/G cg25622487 chr11:95524042 FAM76B;CEP57 0.5 7.02 0.36 1.27e-11 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs1881797 1.000 rs1881796 chr1:247688931 G/A cg11166453 chr1:247681781 NA 0.43 7.11 0.37 7.14e-12 Acute lymphoblastic leukemia (childhood); CRC cis rs72634258 0.945 rs441597 chr1:8080895 A/G cg26816564 chr1:7831052 VAMP3 0.49 5.67 0.3 3.12e-8 Inflammatory bowel disease; CRC cis rs4664308 0.710 rs13001911 chr2:161020703 G/C cg03641300 chr2:160917029 PLA2R1 -0.65 -10.66 -0.51 5.62e-23 Idiopathic membranous nephropathy; CRC cis rs12024301 0.557 rs12033433 chr1:183594279 T/C cg11505048 chr1:183622726 RGL1;APOBEC4 0.76 6.93 0.36 2.16e-11 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs921968 0.643 rs13431399 chr2:219469498 G/C cg02176678 chr2:219576539 TTLL4 -0.58 -9.17 -0.45 5.41e-18 Mean corpuscular hemoglobin concentration; CRC cis rs2019137 0.560 rs4849179 chr2:113985170 C/T cg02675527 chr2:114030824 PAX8;LOC440839 -0.42 -6.36 -0.33 6.79e-10 Lymphocyte counts; CRC cis rs12926788 0.542 rs11862971 chr16:24767574 C/A cg00339695 chr16:24857497 SLC5A11 0.44 9.1 0.45 8.59e-18 Ejection fraction in Tripanosoma cruzi seropositivity; CRC cis rs1348850 0.598 rs12616259 chr2:178503803 C/T cg22681709 chr2:178499509 PDE11A -0.51 -9.5 -0.46 4.5e-19 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs2204008 0.837 rs7974888 chr12:37945215 A/G cg13010199 chr12:38710504 ALG10B 0.45 6.04 0.32 4.08e-9 Bladder cancer; CRC cis rs4853012 0.838 rs60964317 chr2:74343423 A/T cg19729930 chr2:74357872 NA 0.58 9.11 0.45 8.49e-18 Gestational age at birth (maternal effect); CRC cis rs11690935 0.959 rs6759575 chr2:172689068 C/T cg13550731 chr2:172543902 DYNC1I2 -1.08 -18.07 -0.71 3.63e-51 Schizophrenia; CRC cis rs798554 0.660 rs1182175 chr7:2875026 C/T cg19717773 chr7:2847554 GNA12 0.41 7.1 0.36 7.63e-12 Height; CRC cis rs11122272 0.603 rs2998427 chr1:231528112 A/G cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.56 -8.33 -0.42 2.14e-15 Hemoglobin concentration; CRC cis rs2243480 1.000 rs160633 chr7:65528228 T/C cg18252515 chr7:66147081 NA -1.16 -13.46 -0.6 3.35e-33 Diabetic kidney disease; CRC cis rs1577917 1.000 rs12203924 chr6:86776412 A/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.54 -6.64 -0.34 1.29e-10 Response to antipsychotic treatment; CRC cis rs2882667 0.838 rs11958529 chr5:138395068 C/T cg09476006 chr5:138032270 NA 0.44 7.51 0.38 5.68e-13 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs4665809 0.941 rs41285975 chr2:26351144 T/C cg22920501 chr2:26401640 FAM59B -0.52 -7.15 -0.37 5.68e-12 Gut microbiome composition (summer); CRC cis rs9322193 0.884 rs11155675 chr6:150064019 T/C cg13206674 chr6:150067644 NUP43 0.67 9.62 0.47 1.84e-19 Lung cancer; CRC cis rs34172651 0.517 rs11647120 chr16:24819806 A/G cg00339695 chr16:24857497 SLC5A11 0.42 8.63 0.43 2.58e-16 Intelligence (multi-trait analysis); CRC cis rs10919791 0.501 rs4915189 chr1:199916450 C/A cg13229857 chr1:200006247 NR5A2 0.43 6.51 0.34 2.89e-10 Pancreatic cancer; CRC cis rs6502050 0.698 rs67143649 chr17:80117772 C/G cg25804541 chr17:80189381 SLC16A3 -0.31 -5.98 -0.31 5.73e-9 Life satisfaction; CRC cis rs9322193 0.923 rs2297932 chr6:150039361 C/G cg00933542 chr6:150070202 PCMT1 0.31 6.38 0.33 6.16e-10 Lung cancer; CRC cis rs9462027 0.630 rs9469871 chr6:34745007 A/T cg07306190 chr6:34760872 UHRF1BP1 -0.35 -6.23 -0.33 1.4e-9 Systemic lupus erythematosus; CRC cis rs7692995 1.000 rs73098845 chr4:17940718 C/A cg08925142 chr4:18023851 LCORL -0.53 -5.84 -0.31 1.27e-8 Height; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg14967814 chr3:179041370 ZNF639 0.4 6.01 0.31 4.89e-9 Intelligence (multi-trait analysis); CRC trans rs10506458 0.915 rs1009540 chr12:63414872 C/A cg03429785 chr15:59498649 MYO1E;LDHAL6B -1.41 -20.54 -0.75 6.41e-61 Hemostatic factors and hematological phenotypes; CRC cis rs73206853 0.841 rs56130410 chr12:110824112 C/T cg12870014 chr12:110450643 ANKRD13A 0.8 7.68 0.39 1.89e-13 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC cis rs4722166 0.603 rs7801406 chr7:22788274 A/G cg26061582 chr7:22766209 IL6 0.55 8.3 0.42 2.74e-15 Lung cancer; CRC cis rs4780401 0.755 rs7194034 chr16:11770777 A/G cg01061890 chr16:11836724 TXNDC11 -0.43 -5.89 -0.31 9.69e-9 Rheumatoid arthritis; CRC cis rs4727027 0.835 rs6959224 chr7:148784495 A/G cg12479418 chr7:148823350 ZNF425;ZNF398 0.42 5.84 0.31 1.27e-8 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC cis rs9916302 0.808 rs6503515 chr17:37606433 G/T cg00129232 chr17:37814104 STARD3 -0.55 -8.17 -0.41 6.79e-15 Glomerular filtration rate (creatinine); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg00974835 chr14:74960278 NPC2;ISCA2 0.38 6.24 0.33 1.37e-9 Liver disease severity in Alagille syndrome; CRC cis rs13064411 0.518 rs7646188 chr3:113219272 C/T cg18753928 chr3:113234510 CCDC52 -0.48 -7.67 -0.39 2.01e-13 Response to simvastatin treatment (PCSK9 protein level change); CRC cis rs12476592 0.571 rs68183503 chr2:63802888 C/T cg10828910 chr2:63850056 LOC388955 0.49 6.11 0.32 2.79e-9 Childhood ear infection; CRC cis rs11792861 0.926 rs75472294 chr9:111804239 G/A cg05043794 chr9:111880884 C9orf5 -0.35 -6.44 -0.33 4.2e-10 Menarche (age at onset); CRC cis rs832540 0.556 rs4146565 chr5:56093825 T/C cg24531977 chr5:56204891 C5orf35 -0.53 -7.9 -0.4 4.28e-14 Coronary artery disease; CRC cis rs875971 0.522 rs7784623 chr7:65395034 T/G cg02869306 chr7:64672164 INTS4L1 -0.35 -5.89 -0.31 9.64e-9 Aortic root size; CRC cis rs6502050 0.835 rs7406220 chr17:80077850 T/C cg13198984 chr17:80129470 CCDC57 -0.48 -8.58 -0.43 3.8e-16 Life satisfaction; CRC cis rs7605827 0.836 rs1549016 chr2:15616859 G/A cg19274914 chr2:15703543 NA 0.39 5.95 0.31 6.89e-9 Educational attainment (years of education); CRC trans rs9858542 0.953 rs9824092 chr3:49674147 C/G cg21582582 chr3:182698605 DCUN1D1 -0.57 -6.84 -0.35 3.77e-11 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg08102688 chr12:49463918 RHEBL1 0.47 6.56 0.34 2.06e-10 Anxiety disorder; CRC cis rs6502050 0.835 rs34867501 chr17:80121358 T/C cg11859384 chr17:80120422 CCDC57 -0.36 -5.75 -0.3 2.06e-8 Life satisfaction; CRC cis rs644799 1.000 rs560854 chr11:95584905 G/A cg25622487 chr11:95524042 FAM76B;CEP57 0.74 11.5 0.54 5.71e-26 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg17658546 chr4:90032747 TIGD2 0.46 6.47 0.34 3.64e-10 Response to antipsychotic treatment; CRC cis rs4689592 0.503 rs2292461 chr4:7058473 C/T cg06697600 chr4:7070879 GRPEL1 -0.53 -7.2 -0.37 4e-12 Monocyte percentage of white cells; CRC cis rs743757 1.000 rs9835537 chr3:50464335 T/C cg09545109 chr3:50388910 TUSC4;CYB561D2 0.44 6.41 0.33 4.95e-10 Diastolic blood pressure; CRC cis rs6121246 0.529 rs750144 chr20:30179027 C/T cg18721089 chr20:30220636 NA 0.55 8.23 0.41 4.3e-15 Mean corpuscular hemoglobin; CRC cis rs875971 0.522 rs1917563 chr7:65415647 C/T cg18912574 chr7:65842487 NCRNA00174 -0.33 -5.62 -0.3 4.12e-8 Aortic root size; CRC cis rs11098499 0.908 rs28499576 chr4:120386677 G/A cg24375607 chr4:120327624 NA 0.5 7.73 0.39 1.32e-13 Corneal astigmatism; CRC cis rs9309711 0.506 rs9284794 chr2:3492052 G/A cg10845886 chr2:3471009 TTC15 -0.45 -7.17 -0.37 4.89e-12 Neurofibrillary tangles; CRC cis rs4547160 0.888 rs10877953 chr12:63488462 C/T cg26727693 chr12:63544175 AVPR1A 0.46 9.28 0.46 2.32e-18 Morning vs. evening chronotype; CRC cis rs7613875 0.580 rs11709503 chr3:49991167 G/T cg24110177 chr3:50126178 RBM5 -0.52 -7.81 -0.4 7.86e-14 Body mass index; CRC cis rs892961 0.932 rs9916143 chr17:75409282 C/G cg01320579 chr17:75405842 SEPT9 -0.36 -5.76 -0.3 1.88e-8 Airflow obstruction; CRC cis rs10751667 0.666 rs10902247 chr11:953686 G/A cg23136738 chr11:925521 AP2A2 -0.42 -7.05 -0.36 1.03e-11 Alzheimer's disease (late onset); CRC cis rs4604732 0.631 rs1106720 chr1:247624681 T/C cg12754571 chr1:247694271 LOC148824;OR2C3 0.41 5.79 0.3 1.64e-8 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CRC cis rs11122272 0.735 rs2474634 chr1:231487017 T/C cg06096015 chr1:231504339 EGLN1 0.38 5.9 0.31 8.93e-9 Hemoglobin concentration; CRC cis rs17092148 0.945 rs6058115 chr20:33358397 T/G cg08999081 chr20:33150536 PIGU 0.46 5.68 0.3 3.01e-8 Neuroticism; CRC cis rs9443645 0.611 rs10943616 chr6:79823541 G/A cg09184832 chr6:79620586 NA -0.39 -6.66 -0.34 1.18e-10 Intelligence (multi-trait analysis); CRC cis rs881375 1.000 rs10818480 chr9:123643170 T/C cg09419670 chr9:123605666 PSMD5;LOC253039 0.58 8.48 0.42 7.52e-16 Rheumatoid arthritis; CRC cis rs9303401 0.632 rs7502541 chr17:57241019 G/C cg02118635 chr17:56770003 RAD51C;TEX14 0.47 6.93 0.36 2.23e-11 Cognitive test performance; CRC cis rs1552244 0.882 rs17081288 chr3:10042113 A/G cg02579736 chr3:10068473 FANCD2;CIDECP 0.96 12.39 0.56 3.4e-29 Alzheimer's disease; CRC cis rs736408 0.736 rs4687550 chr3:52823430 T/G cg15147215 chr3:52552868 STAB1 -0.56 -8.49 -0.42 7.14e-16 Bipolar disorder; CRC cis rs2243480 0.901 rs778732 chr7:65822360 C/T cg25985355 chr7:65971099 NA -0.56 -6.32 -0.33 8.58e-10 Diabetic kidney disease; CRC cis rs1799949 1.000 rs33994002 chr17:41328818 T/A cg23758822 chr17:41437982 NA 0.8 13.62 0.6 8.51e-34 Menopause (age at onset); CRC cis rs2019137 0.936 rs3828188 chr2:113954247 G/A cg21610815 chr2:113994035 PAX8;LOC654433;LOC440839 -0.45 -6.28 -0.33 1.09e-9 Lymphocyte counts; CRC cis rs6496667 0.779 rs7169182 chr15:91024343 C/G cg04176472 chr15:90893244 GABARAPL3 0.53 7.75 0.39 1.15e-13 Rheumatoid arthritis; CRC cis rs736801 0.569 rs11748193 chr5:131725329 A/T cg11843238 chr5:131593191 PDLIM4 0.33 5.78 0.3 1.72e-8 Breast cancer;Mosquito bite size; CRC trans rs1814175 0.817 rs10769613 chr11:49769692 G/A cg03929089 chr4:120376271 NA -0.94 -17.78 -0.7 4.88e-50 Height; CRC cis rs7705042 0.865 rs449454 chr5:141533062 A/G cg08523384 chr5:141488047 NDFIP1 -0.32 -5.72 -0.3 2.4e-8 Asthma; CRC cis rs2996428 0.667 rs7545274 chr1:3744261 G/T cg13057898 chr1:3703894 LRRC47 0.54 7.06 0.36 9.71e-12 Red cell distribution width; CRC cis rs12540874 1.000 rs12540874 chr7:50664922 A/G cg14593290 chr7:50529359 DDC -0.44 -6.08 -0.32 3.34e-9 Systemic sclerosis; CRC trans rs11252926 0.550 rs10795122 chr10:466830 C/T cg00953403 chr17:74099816 EXOC7 0.49 7.33 0.37 1.75e-12 Psychosis in Alzheimer's disease; CRC cis rs7769051 0.522 rs10457596 chr6:133169974 T/G cg22852734 chr6:133119734 C6orf192 0.89 7.64 0.39 2.44e-13 Type 2 diabetes nephropathy; CRC cis rs9914988 0.673 rs12325788 chr17:27080049 G/A cg20469991 chr17:27169893 C17orf63 -0.48 -6.15 -0.32 2.26e-9 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs77956314 0.515 rs4767473 chr12:117365506 C/T cg02017074 chr12:117425053 FBXW8 0.61 7.6 0.39 3.08e-13 Subcortical brain region volumes;Hippocampal volume; CRC cis rs17270561 0.579 rs10456326 chr6:25919662 G/A cg16482183 chr6:26056742 HIST1H1C 1.02 12.44 0.57 2.13e-29 Iron status biomarkers; CRC trans rs7937682 0.889 rs558736 chr11:111500760 C/G cg18187862 chr3:45730750 SACM1L 0.48 6.86 0.35 3.32e-11 Primary sclerosing cholangitis; CRC cis rs798554 0.797 rs2107964 chr7:2863574 G/A cg19346786 chr7:2764209 NA -0.45 -7.6 -0.39 3.02e-13 Height; CRC cis rs736408 0.509 rs13083798 chr3:52649748 A/G cg18099408 chr3:52552593 STAB1 -0.53 -9.75 -0.47 6.88e-20 Bipolar disorder; CRC cis rs1218582 0.688 rs2135219 chr1:154857217 G/A cg24250549 chr1:154909240 PMVK 0.57 8.31 0.42 2.53e-15 Prostate cancer; CRC cis rs9902453 0.765 rs9890747 chr17:28007442 A/G cg26525008 chr17:28256777 EFCAB5;SSH2 0.72 12.14 0.56 2.78e-28 Coffee consumption (cups per day); CRC cis rs921968 0.541 rs523937 chr2:219437596 G/C cg02176678 chr2:219576539 TTLL4 0.53 8.41 0.42 1.22e-15 Mean corpuscular hemoglobin concentration; CRC cis rs59918340 0.692 rs6983780 chr8:142231944 G/A cg17298326 chr8:142245477 NA -0.38 -5.79 -0.3 1.61e-8 Immature fraction of reticulocytes; CRC cis rs7615952 0.599 rs6438955 chr3:125730333 C/A cg05084668 chr3:125655381 ALG1L -0.52 -8.13 -0.41 9.09e-15 Blood pressure (smoking interaction); CRC cis rs9733 0.566 rs11204675 chr1:150570985 A/C cg17724175 chr1:150552817 MCL1 -0.53 -9.04 -0.45 1.42e-17 Tonsillectomy; CRC cis rs3736485 0.609 rs11638154 chr15:51969416 C/T cg08986416 chr15:51914746 DMXL2 -0.39 -5.66 -0.3 3.3e-8 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs8106542 0.789 rs10420809 chr19:10727014 A/G cg17710535 chr19:10819994 QTRT1 -0.42 -5.93 -0.31 7.51e-9 Platelet distribution width; CRC cis rs1799949 1.000 rs11657835 chr17:41291953 C/G cg05368731 chr17:41323189 NBR1 0.65 9.59 0.47 2.27e-19 Menopause (age at onset); CRC cis rs6502050 0.865 rs74480314 chr17:80117716 C/T cg02741985 chr17:80059408 CCDC57 0.43 7.17 0.37 5.1e-12 Life satisfaction; CRC cis rs801193 0.967 rs3800823 chr7:66147110 C/A cg18876405 chr7:65276391 NA -0.57 -9.75 -0.47 7.01e-20 Aortic root size; CRC cis rs7737355 0.947 rs244739 chr5:130806874 A/C cg06307176 chr5:131281290 NA -0.42 -6.21 -0.32 1.57e-9 Life satisfaction; CRC cis rs757110 0.902 rs2074310 chr11:17421886 T/C cg15432903 chr11:17409602 KCNJ11 0.74 10.59 0.5 9.48e-23 Type 2 diabetes; CRC cis rs736801 0.607 rs11739135 chr5:131733397 C/G cg14196790 chr5:131705035 SLC22A5 0.35 5.61 0.3 4.3e-8 Breast cancer;Mosquito bite size; CRC cis rs478304 0.934 rs610037 chr11:65546857 A/C cg08755490 chr11:65554678 OVOL1 0.4 5.85 0.31 1.16e-8 Acne (severe); CRC cis rs1065656 0.589 rs391543 chr16:1915583 T/G cg14074117 chr16:1909714 C16orf73 -0.35 -6.03 -0.32 4.35e-9 Insulin-like growth factors; CRC trans rs752010 0.619 rs7539238 chr1:42113572 A/C cg02512902 chr17:25799447 KSR1 0.4 6.0 0.31 5.23e-9 Lupus nephritis in systemic lupus erythematosus; CRC cis rs4969178 0.600 rs4969183 chr17:76393372 A/G cg02319466 chr17:76381040 PGS1 0.39 6.18 0.32 1.88e-9 HDL cholesterol levels; CRC cis rs6691722 0.503 rs2274167 chr1:24707296 C/T cg02336364 chr1:24764700 NIPAL3 0.38 6.34 0.33 7.67e-10 Response to interferon beta in multiple sclerosis; CRC cis rs826838 0.967 rs11169169 chr12:39093153 A/C cg26384229 chr12:38710491 ALG10B 0.73 10.2 0.49 2.1e-21 Heart rate; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg23057943 chr5:137877800 ETF1 0.42 6.27 0.33 1.17e-9 Intelligence (multi-trait analysis); CRC cis rs6831352 0.918 rs17218073 chr4:100055739 G/A cg12011299 chr4:100065546 ADH4 -0.49 -9.27 -0.45 2.61e-18 Alcohol dependence; CRC cis rs9309711 0.643 rs4535074 chr2:3481637 A/G cg15506890 chr2:3487001 NA -0.54 -8.79 -0.44 8.53e-17 Neurofibrillary tangles; CRC trans rs9467711 0.606 rs9379873 chr6:26402717 T/C cg06606381 chr12:133084897 FBRSL1 -0.8 -6.11 -0.32 2.85e-9 Autism spectrum disorder or schizophrenia; CRC cis rs4665809 1.000 rs4665820 chr2:26309150 T/C cg22920501 chr2:26401640 FAM59B -0.53 -7.23 -0.37 3.4e-12 Gut microbiome composition (summer); CRC cis rs3540 0.533 rs11633692 chr15:91056043 G/A cg22089800 chr15:90895588 ZNF774 -0.58 -9.57 -0.47 2.68e-19 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; CRC cis rs1707322 1.000 rs10789479 chr1:46352500 T/C cg03146154 chr1:46216737 IPP 0.57 7.84 0.4 6.2e-14 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs7772486 0.686 rs857880 chr6:145971115 T/C cg05347473 chr6:146136440 FBXO30 -0.38 -5.67 -0.3 3.17e-8 Lobe attachment (rater-scored or self-reported); CRC cis rs875971 1.000 rs4717292 chr7:65895598 G/A cg00343986 chr7:65444356 GUSB 0.43 6.29 0.33 1.03e-9 Aortic root size; CRC cis rs875971 0.825 rs1129531 chr7:65619104 C/T cg18252515 chr7:66147081 NA 0.39 5.62 0.3 4.1e-8 Aortic root size; CRC cis rs10504229 0.683 rs56235637 chr8:58106008 T/C cg04204079 chr8:58130323 NA -0.46 -5.79 -0.3 1.67e-8 Developmental language disorder (linguistic errors); CRC cis rs7666738 0.570 rs11097612 chr4:99079772 T/C cg05340658 chr4:99064831 C4orf37 0.49 7.21 0.37 3.95e-12 Colonoscopy-negative controls vs population controls; CRC cis rs4713675 0.584 rs9380375 chr6:33682391 G/A cg14003231 chr6:33640908 ITPR3 0.49 7.97 0.4 2.64e-14 Plateletcrit; CRC trans rs1005277 0.579 rs1780136 chr10:38501453 A/G cg23533926 chr12:111358616 MYL2 -0.56 -8.67 -0.43 1.97e-16 Extrinsic epigenetic age acceleration; CRC cis rs7725052 0.609 rs11954069 chr5:40452233 T/A cg09067459 chr5:40385259 NA -0.4 -6.56 -0.34 2.05e-10 Pediatric autoimmune diseases; CRC cis rs9926296 0.744 rs154657 chr16:89708096 A/G cg03605463 chr16:89740564 NA -0.59 -9.14 -0.45 6.67e-18 Vitiligo; CRC cis rs2952156 0.920 rs2934953 chr17:37832315 T/A cg20243544 chr17:37824526 PNMT 0.55 8.45 0.42 9.24e-16 Asthma; CRC cis rs3768617 0.528 rs4652778 chr1:183097420 C/T ch.1.3577855R chr1:183094577 LAMC1 0.88 15.3 0.64 2.7e-40 Fuchs's corneal dystrophy; CRC cis rs3741151 1.000 rs78433080 chr11:73067565 G/A cg17517138 chr11:73019481 ARHGEF17 1.12 9.65 0.47 1.47e-19 GIP levels in response to oral glucose tolerance test (120 minutes); CRC trans rs11098499 0.874 rs6822498 chr4:120120183 T/C cg25214090 chr10:38739885 LOC399744 0.52 7.73 0.39 1.34e-13 Corneal astigmatism; CRC cis rs227584 0.663 rs3180912 chr17:42259463 A/G cg09913183 chr17:42254507 C17orf65;ASB16 0.49 7.41 0.38 1.06e-12 Bone mineral density (hip);Bone mineral density; CRC cis rs7224685 0.501 rs4790169 chr17:4022665 G/A cg11204139 chr17:3907470 NA -0.76 -13.81 -0.61 1.55e-34 Type 2 diabetes; CRC trans rs7267979 1.000 rs2297496 chr20:25295787 T/C cg17903999 chr18:56338584 MALT1 0.42 6.94 0.36 2.07e-11 Liver enzyme levels (alkaline phosphatase); CRC cis rs1129187 0.967 rs6941212 chr6:42915920 A/G cg27588902 chr6:42928151 GNMT -0.38 -6.85 -0.35 3.69e-11 Alzheimer's disease in APOE e4+ carriers; CRC cis rs2243480 1.000 rs160655 chr7:65533214 T/C cg12463550 chr7:65579703 CRCP 0.67 6.39 0.33 5.56e-10 Diabetic kidney disease; CRC cis rs614226 1.000 rs580016 chr12:120933977 T/C cg27489772 chr12:121021490 NA -0.46 -5.93 -0.31 7.77e-9 Type 1 diabetes nephropathy; CRC cis rs6424115 0.830 rs2502999 chr1:24198321 A/G cg15997130 chr1:24165203 NA 0.72 10.69 0.51 4.31e-23 Immature fraction of reticulocytes; CRC cis rs3849570 0.533 rs6785385 chr3:81989850 A/G cg07356753 chr3:81810745 GBE1 -0.48 -6.4 -0.33 5.35e-10 Waist circumference;Body mass index; CRC cis rs28386778 0.897 rs2584617 chr17:61925298 C/T cg25654072 chr17:61904446 PSMC5;FTSJ3 0.7 10.97 0.52 4.47e-24 Prudent dietary pattern; CRC cis rs77972916 0.611 rs10495899 chr2:43602304 C/G cg06169590 chr2:43455088 ZFP36L2;LOC100129726 -0.5 -6.14 -0.32 2.4e-9 Granulocyte percentage of myeloid white cells; CRC cis rs17362650 0.960 rs12469362 chr2:9618957 T/C cg12832956 chr2:9616023 IAH1 -0.5 -6.13 -0.32 2.55e-9 Alcohol dependence (age at onset); CRC cis rs2971970 0.519 rs6467513 chr7:133687565 T/G cg03336402 chr7:133662267 EXOC4 -0.63 -9.24 -0.45 3.04e-18 Intelligence (multi-trait analysis); CRC cis rs6967414 0.786 rs3757482 chr7:6748927 A/G cg00387323 chr7:6746715 ZNF12 0.58 5.61 0.3 4.4e-8 Hematocrit;Hemoglobin concentration; CRC cis rs7811142 0.779 rs111312383 chr7:99905325 C/T cg00814883 chr7:100076585 TSC22D4 -0.67 -7.99 -0.4 2.32e-14 Platelet count; CRC cis rs2836974 0.644 rs2836986 chr21:40702136 A/C cg11644478 chr21:40555479 PSMG1 -0.62 -9.35 -0.46 1.42e-18 Cognitive function; CRC cis rs3760982 0.585 rs11673490 chr19:44298885 C/A cg11993925 chr19:44307056 LYPD5 0.57 10.3 0.49 9.35e-22 Breast cancer (estrogen-receptor negative);Breast cancer; CRC cis rs9926296 0.605 rs12599180 chr16:89839306 C/T cg03388025 chr16:89894329 SPIRE2 -0.42 -8.35 -0.42 1.91e-15 Vitiligo; CRC cis rs447735 0.565 rs10852626 chr16:89914633 T/G cg27121462 chr16:89883253 FANCA 0.39 5.71 0.3 2.46e-8 Hemoglobin concentration; CRC trans rs360798 0.512 rs2710642 chr2:63149557 G/A cg05376469 chr2:102649931 NA -0.39 -6.12 -0.32 2.59e-9 Coronary artery disease; CRC cis rs10744422 1.000 rs2292135 chr12:123334075 G/A cg25930673 chr12:123319894 HIP1R -0.6 -6.32 -0.33 8.51e-10 Schizophrenia; CRC cis rs1322512 0.917 rs2758781 chr6:153008828 C/T cg03415253 chr6:152958462 SYNE1 0.4 6.04 0.32 4.14e-9 Tonometry; CRC cis rs9291683 0.588 rs2240722 chr4:10020757 A/G cg00071950 chr4:10020882 SLC2A9 0.68 13.11 0.59 7.01e-32 Bone mineral density; CRC cis rs6684514 1.000 rs12024813 chr1:156224529 C/A cg16558208 chr1:156270281 VHLL 0.62 9.7 0.47 9.8e-20 Mean corpuscular hemoglobin concentration;Glycated hemoglobin levels; CRC cis rs514406 0.644 rs1855127 chr1:53199594 A/G cg08859206 chr1:53392774 SCP2 0.41 6.42 0.33 4.9e-10 Monocyte count; CRC cis rs7584330 0.628 rs73098849 chr2:238389739 G/A cg14458575 chr2:238380390 NA 0.71 9.96 0.48 1.38e-20 Prostate cancer; CRC cis rs514406 0.505 rs395169 chr1:53174071 G/A cg08859206 chr1:53392774 SCP2 -0.4 -6.05 -0.32 3.87e-9 Monocyte count; CRC cis rs897984 0.762 rs12931046 chr16:30987144 G/A cg00531865 chr16:30841666 NA 0.47 6.59 0.34 1.75e-10 Dementia with Lewy bodies; CRC cis rs2304069 0.826 rs2244195 chr5:149403528 C/A cg22760475 chr5:149380129 HMGXB3;TIGD6 0.87 10.11 0.49 4.35e-21 HIV-1 control; CRC cis rs9916302 0.821 rs1966915 chr17:37425262 A/C cg00129232 chr17:37814104 STARD3 -0.54 -8.07 -0.41 1.29e-14 Glomerular filtration rate (creatinine); CRC cis rs951366 0.789 rs1775154 chr1:205696615 T/A cg26354017 chr1:205819088 PM20D1 0.74 11.12 0.52 1.29e-24 Menarche (age at onset); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg12439463 chr17:79848761 ANAPC11;THOC4 0.45 6.27 0.33 1.16e-9 Response to antipsychotic treatment; CRC cis rs728616 0.557 rs17107449 chr10:81715696 C/T cg05935833 chr10:81318306 SFTPA2 -0.73 -8.0 -0.4 2.14e-14 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs950169 0.763 rs35372971 chr15:84941795 G/A cg11189052 chr15:85197271 WDR73 0.63 8.81 0.44 7.35e-17 Schizophrenia; CRC cis rs3733585 0.673 rs9994266 chr4:9954450 C/T cg00071950 chr4:10020882 SLC2A9 -0.53 -9.31 -0.46 1.87e-18 Cleft plate (environmental tobacco smoke interaction); CRC cis rs780094 0.564 rs4665978 chr2:27648726 T/C cg02592271 chr2:27665507 KRTCAP3 -0.26 -5.98 -0.31 5.95e-9 Calcium levels;Fasting blood insulin;Metabolic traits;Triglyceride levels;Fasting plasma glucose;Urate levels in overweight individuals;Urate levels in obese individuals;Uric acid levels;Height;Age-related diseases, mortality and associated endophenotypes;Renal underexcretion gout;Fasting blood glucose (BMI interaction);Urate levels;Gondoic acid (20:1n-9) levels;Fasting blood insulin (BMI interaction);Triglycerides;Plasma omega-3 polyunsaturated fatty acid levels (docosapentaenoic acid);Type 2 diabetes;Nonalcoholic fatty liver disease;Hypertriglyceridemia;C-reactive protein;Age-related disease endophenotypes;LDL cholesterol;Metabolic syndrome;Crohn's disease;Alcohol consumption (drinks per week);Homeostasis model assessment of insulin resistance;Alcohol consumption;Red blood cell count;Fasting blood glucose; CRC cis rs10504229 0.815 rs72650877 chr8:58164510 T/C cg20607798 chr8:58055168 NA 0.48 5.87 0.31 1.08e-8 Developmental language disorder (linguistic errors); CRC cis rs7072216 0.763 rs6584204 chr10:100173580 C/G cg26618903 chr10:100175079 PYROXD2 -0.55 -8.99 -0.44 2.03e-17 Metabolite levels; CRC cis rs8103278 0.507 rs7260651 chr19:46260245 G/A cg02376097 chr19:46275166 DMPK 0.37 5.89 0.31 9.66e-9 Coronary artery disease; CRC cis rs4731207 0.698 rs2040926 chr7:124457295 C/G cg23710748 chr7:124431027 NA -0.38 -6.13 -0.32 2.58e-9 Cutaneous malignant melanoma; CRC cis rs4665809 1.000 rs4665809 chr2:26251361 C/T cg22920501 chr2:26401640 FAM59B 0.51 6.84 0.35 3.87e-11 Gut microbiome composition (summer); CRC cis rs9311676 0.632 rs62258126 chr3:58396114 T/C cg06643156 chr3:58380774 PXK 0.41 6.33 0.33 7.82e-10 Systemic lupus erythematosus; CRC cis rs7605378 0.528 rs281787 chr2:200784238 C/T cg17644776 chr2:200775616 C2orf69 -0.5 -7.99 -0.4 2.23e-14 Osteoporosis; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg04865480 chr2:173421027 PDK1 0.38 6.68 0.35 1.01e-10 Liver disease severity in Alagille syndrome; CRC trans rs916888 0.773 rs9896243 chr17:44826056 C/G cg22433210 chr17:43662623 NA 0.86 8.77 0.44 9.94e-17 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs10504229 0.635 rs72649130 chr8:58053810 G/T cg24829409 chr8:58192753 C8orf71 -0.68 -8.25 -0.41 3.95e-15 Developmental language disorder (linguistic errors); CRC cis rs6665290 0.901 rs61834001 chr1:227197411 C/T cg10327440 chr1:227177885 CDC42BPA -1.05 -23.43 -0.79 4.22e-72 Myeloid white cell count; CRC cis rs7777754 0.512 rs3757472 chr7:50537983 A/C cg14593290 chr7:50529359 DDC -0.51 -7.65 -0.39 2.28e-13 Response to zileuton treatment in asthma (FEV1 change interaction); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg23661578 chr6:42981936 MEA1;KLHDC3 0.37 6.08 0.32 3.28e-9 Liver disease severity in Alagille syndrome; CRC cis rs10992471 0.528 rs7022562 chr9:95216340 A/G cg14631576 chr9:95140430 CENPP -0.31 -5.63 -0.3 3.78e-8 Visceral adipose tissue/subcutaneous adipose tissue ratio; CRC cis rs9318086 0.687 rs9507182 chr13:24442365 G/A cg25267304 chr13:24462978 PCOTH;MIPEP 0.61 9.93 0.48 1.74e-20 Myopia (pathological); CRC cis rs10504229 0.683 rs7464038 chr8:58111908 T/C cg02725872 chr8:58115012 NA -0.66 -11.21 -0.53 6.44e-25 Developmental language disorder (linguistic errors); CRC trans rs7730934 1.000 rs11741953 chr5:55267814 T/C cg10323188 chr3:28613979 NA 0.52 6.11 0.32 2.84e-9 Blood protein levels; CRC trans rs6703335 0.870 rs10803142 chr1:243598234 A/G cg24815885 chr19:36486437 SDHAF1 0.43 6.06 0.32 3.73e-9 Schizophrenia;Schizophrenia, schizoaffective disorder or bipolar disorder; CRC cis rs13118159 0.505 rs1250128 chr4:1257311 T/C cg19318889 chr4:1322082 MAEA -0.68 -9.79 -0.47 5.05e-20 Longevity; CRC cis rs9291683 0.632 rs10939669 chr4:10045827 A/G cg11266682 chr4:10021025 SLC2A9 0.53 11.09 0.52 1.76e-24 Bone mineral density; CRC cis rs977987 0.966 rs62060551 chr16:75502312 A/C cg03315344 chr16:75512273 CHST6 0.55 9.3 0.46 1.99e-18 Dupuytren's disease; CRC cis rs12477438 0.520 rs6756650 chr2:99801800 T/C cg14399236 chr2:99771627 LIPT1;TSGA10 0.81 14.32 0.62 1.66e-36 Chronic sinus infection; CRC cis rs10493773 0.609 rs12058974 chr1:86192235 T/A cg17807903 chr1:86174739 ZNHIT6 -0.65 -17.72 -0.7 8.7e-50 Urate levels in overweight individuals; CRC cis rs6460942 0.591 rs4721078 chr7:12334657 T/A cg06484146 chr7:12443880 VWDE -0.64 -6.83 -0.35 4.2e-11 Coronary artery disease; CRC cis rs614226 0.938 rs12857 chr12:120933946 T/G cg27489772 chr12:121021490 NA 0.42 5.87 0.31 1.05e-8 Type 1 diabetes nephropathy; CRC cis rs6754459 0.502 rs34759180 chr2:3707394 C/T cg19052272 chr2:3704530 ALLC -1.04 -12.03 -0.55 7.25e-28 Response to inhaled corticosteroid treatment in asthma (change in FEV1); CRC cis rs113835537 0.529 rs75685325 chr11:66235242 A/G cg22134325 chr11:66188745 NPAS4 0.28 5.65 0.3 3.39e-8 Airway imaging phenotypes; CRC cis rs668210 0.739 rs1151511 chr11:65756283 A/G cg02202077 chr11:65769826 EIF1AD;BANF1 0.48 6.43 0.33 4.57e-10 Cerebrospinal fluid biomarker levels; CRC cis rs950169 1.000 rs1848093 chr15:84755527 G/C cg11189052 chr15:85197271 WDR73 0.6 8.83 0.44 6.13e-17 Schizophrenia; CRC cis rs4713118 0.512 rs2622319 chr6:28120401 G/C cg12273811 chr6:28175739 NA 0.61 8.81 0.44 7.35e-17 Parkinson's disease; CRC cis rs3806843 0.900 rs2262576 chr5:140135536 T/C cg19875535 chr5:140030758 IK -0.53 -8.29 -0.42 2.99e-15 Depressive symptoms (multi-trait analysis); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg08611093 chr12:57856004 GLI1 0.43 6.5 0.34 2.95e-10 Intelligence (multi-trait analysis); CRC cis rs10751667 0.666 rs11246357 chr11:963980 A/C cg06064525 chr11:970664 AP2A2 -0.3 -6.11 -0.32 2.77e-9 Alzheimer's disease (late onset); CRC cis rs2153535 0.546 rs1335640 chr6:8485325 A/C cg21535247 chr6:8435926 SLC35B3 0.5 7.51 0.38 5.54e-13 Motion sickness; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg27652795 chr2:219265373 CTDSP1 0.45 6.21 0.32 1.6e-9 Response to antipsychotic treatment; CRC cis rs6815814 0.861 rs10004195 chr4:38784724 T/A cg06935464 chr4:38784597 TLR10 0.66 8.45 0.42 9.62e-16 Breast cancer; CRC cis rs7666738 0.830 rs28729647 chr4:99059552 T/C cg17366294 chr4:99064904 C4orf37 0.46 7.74 0.39 1.27e-13 Colonoscopy-negative controls vs population controls; CRC cis rs7666738 0.830 rs34892904 chr4:98938097 T/C cg05340658 chr4:99064831 C4orf37 0.6 9.35 0.46 1.41e-18 Colonoscopy-negative controls vs population controls; CRC cis rs6546550 0.900 rs897122 chr2:70140271 C/T cg02498382 chr2:70120550 SNRNP27 -0.56 -9.52 -0.46 3.78e-19 Prevalent atrial fibrillation; CRC cis rs6681460 1.000 rs6680876 chr1:67129482 G/A cg02459107 chr1:67143332 SGIP1 0.47 8.26 0.41 3.48e-15 Presence of antiphospholipid antibodies; CRC cis rs7829975 0.714 rs11784052 chr8:8671962 C/T cg06636001 chr8:8085503 FLJ10661 0.64 10.02 0.48 8.68e-21 Mood instability; CRC cis rs7412746 0.611 rs4970931 chr1:150910727 G/A cg10589385 chr1:150898437 SETDB1 0.27 5.92 0.31 7.89e-9 Melanoma; CRC cis rs4555082 0.874 rs2816611 chr14:105722976 G/C cg13114125 chr14:105738426 BRF1 -0.79 -11.73 -0.54 8.56e-27 Mean platelet volume;Platelet distribution width; CRC trans rs1814175 0.647 rs2903409 chr11:49953612 C/G cg21153622 chr11:89784906 NA -0.42 -6.97 -0.36 1.72e-11 Height; CRC cis rs7727544 0.716 rs2089855 chr5:131573529 A/G cg02033258 chr5:131593261 PDLIM4 0.35 6.69 0.35 9.47e-11 Blood metabolite levels; CRC cis rs282587 0.569 rs1278658 chr13:113386832 G/C cg04656015 chr13:113407548 ATP11A 0.63 7.9 0.4 4.11e-14 Glycated hemoglobin levels; CRC cis rs9916302 0.847 rs7218670 chr17:37500424 G/A cg15445000 chr17:37608096 MED1 -0.44 -9.76 -0.47 6.22e-20 Glomerular filtration rate (creatinine); CRC cis rs2832191 0.716 rs7284006 chr21:30475186 T/A cg08807101 chr21:30365312 RNF160 0.7 11.16 0.52 9.62e-25 Dental caries; CRC cis rs2180341 0.782 rs6569490 chr6:127729615 C/T cg24812749 chr6:127587940 RNF146 0.67 9.02 0.45 1.59e-17 Breast cancer; CRC cis rs1965732 1.000 rs6707320 chr2:3708966 A/G cg00999904 chr2:3704751 ALLC -0.43 -6.16 -0.32 2.09e-9 Response to inhaled corticosteroid treatment in asthma (change in FEV1); CRC cis rs2075371 1.000 rs2544210 chr7:133971535 C/T cg11752832 chr7:134001865 SLC35B4 0.47 7.2 0.37 4.06e-12 Mean platelet volume; CRC cis rs35146811 0.700 rs7788301 chr7:99782753 C/G cg13334819 chr7:99746414 C7orf59 -0.51 -6.72 -0.35 7.79e-11 Coronary artery disease; CRC cis rs9914544 1.000 rs28436199 chr17:18751730 C/T cg26306683 chr17:18585705 ZNF286B 0.5 6.98 0.36 1.62e-11 Educational attainment (years of education); CRC cis rs4665809 1.000 rs6739061 chr2:26256147 C/T cg22920501 chr2:26401640 FAM59B -0.49 -6.83 -0.35 4.12e-11 Gut microbiome composition (summer); CRC cis rs7662987 0.517 rs2602872 chr4:100038996 A/G cg12011299 chr4:100065546 ADH4 0.49 9.38 0.46 1.15e-18 Smoking initiation; CRC cis rs67311347 1.000 rs67680017 chr3:40533164 C/T cg09455208 chr3:40491958 NA 0.43 8.37 0.42 1.72e-15 Renal cell carcinoma; CRC cis rs10883723 0.810 rs10883728 chr10:104269301 A/G cg22532475 chr10:104410764 TRIM8 0.35 6.52 0.34 2.68e-10 Allergic disease (asthma, hay fever or eczema); CRC cis rs9325144 0.532 rs1352121 chr12:39130696 A/G cg26384229 chr12:38710491 ALG10B -0.45 -6.47 -0.34 3.5e-10 Morning vs. evening chronotype; CRC cis rs853679 0.517 rs56364346 chr6:28050762 T/G cg12273811 chr6:28175739 NA 0.71 9.07 0.45 1.08e-17 Depression; CRC cis rs7953508 0.711 rs11107116 chr12:93978504 G/T cg18151635 chr12:93972918 NA -0.72 -9.74 -0.47 7.35e-20 Pubertal anthropometrics; CRC cis rs7772486 0.641 rs960385 chr6:146371074 G/A cg13319975 chr6:146136371 FBXO30 -0.52 -7.21 -0.37 3.78e-12 Lobe attachment (rater-scored or self-reported); CRC cis rs9814567 0.806 rs7626557 chr3:134318213 A/G cg06541857 chr3:134203789 ANAPC13;CEP63 -0.37 -5.73 -0.3 2.3e-8 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs1448094 0.527 rs59445394 chr12:86237843 C/T cg00310523 chr12:86230176 RASSF9 0.36 5.91 0.31 8.75e-9 Major depressive disorder; CRC cis rs1003719 0.715 rs2835657 chr21:38565064 T/C cg10648535 chr21:38446584 PIGP;TTC3 -0.49 -6.89 -0.35 2.93e-11 Eye color traits; CRC cis rs11229555 0.645 rs10896814 chr11:58430699 T/C cg15696309 chr11:58395628 NA -0.72 -7.67 -0.39 1.9e-13 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; CRC cis rs7586879 1.000 rs7608185 chr2:25115432 G/C cg22495460 chr2:25135724 ADCY3 -0.73 -11.97 -0.55 1.19e-27 Body mass index; CRC cis rs7103648 0.695 rs11039290 chr11:47572279 G/A cg20307385 chr11:47447363 PSMC3 0.85 12.42 0.57 2.56e-29 Diastolic blood pressure;Systolic blood pressure; CRC cis rs17711722 0.565 rs73372653 chr7:65442795 A/T cg00343986 chr7:65444356 GUSB 0.46 6.5 0.34 3.03e-10 Calcium levels; CRC cis rs4713118 0.869 rs9283882 chr6:27715258 A/C cg12172441 chr6:28176163 NA 0.53 7.33 0.37 1.85e-12 Parkinson's disease; CRC cis rs10807026 1 rs10807026 chr6:27555519 A/C cg02683197 chr6:28174875 NA -0.43 -5.66 -0.3 3.24e-8 Lung adenocarcinoma; CRC cis rs9287719 0.934 rs6727884 chr2:10757557 C/T cg00105475 chr2:10696890 NA -0.45 -7.18 -0.37 4.77e-12 Prostate cancer; CRC cis rs9409565 0.559 rs11788395 chr9:97251382 T/C cg04523069 chr9:97136363 HIATL1 0.43 5.8 0.3 1.57e-8 Colorectal cancer (alcohol consumption interaction); CRC cis rs4363385 0.553 rs28924721 chr1:152974254 C/T cg25856811 chr1:152973957 SPRR3 -0.22 -5.84 -0.31 1.28e-8 Inflammatory skin disease; CRC cis rs17021463 0.872 rs11097417 chr4:95268071 C/T cg11021082 chr4:95130006 SMARCAD1 -0.47 -7.26 -0.37 2.88e-12 Testicular germ cell tumor; CRC cis rs9311676 0.656 rs6799077 chr3:58404096 C/T cg06643156 chr3:58380774 PXK 0.42 6.38 0.33 5.84e-10 Systemic lupus erythematosus; CRC trans rs11764590 0.715 rs62444907 chr7:2083267 C/T cg11693508 chr17:37793320 STARD3 0.6 6.85 0.35 3.57e-11 Neuroticism; CRC trans rs1005277 0.522 rs289649 chr10:37975384 T/C cg17830980 chr10:43048298 ZNF37B -0.43 -6.61 -0.34 1.6e-10 Extrinsic epigenetic age acceleration; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg09377915 chr6:56295593 NA 0.4 6.11 0.32 2.79e-9 Myopia (pathological); CRC cis rs10426930 0.700 rs7246791 chr19:5013776 T/C cg25246084 chr19:4971487 KDM4B -0.35 -5.94 -0.31 7.17e-9 Monocyte percentage of white cells; CRC cis rs6860806 0.507 rs2631371 chr5:131703691 G/A cg11843238 chr5:131593191 PDLIM4 -0.45 -7.55 -0.38 4.43e-13 Breast cancer; CRC cis rs7772486 0.790 rs7753833 chr6:146161432 C/A cg13319975 chr6:146136371 FBXO30 -0.44 -6.54 -0.34 2.33e-10 Lobe attachment (rater-scored or self-reported); CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg18652121 chr3:179322868 MRPL47;NDUFB5 0.46 6.07 0.32 3.51e-9 Thyroid stimulating hormone; CRC cis rs2637266 0.562 rs35305451 chr10:78408479 A/G cg18941641 chr10:78392320 NA -0.35 -5.83 -0.31 1.3e-8 Pulmonary function; CRC cis rs17685 0.702 rs6960598 chr7:75772991 T/C cg16489192 chr7:75678113 MDH2;STYXL1 -0.36 -5.71 -0.3 2.56e-8 Coffee consumption;Coffee consumption (cups per day); CRC cis rs2075371 0.933 rs432336 chr7:133949064 A/G cg11752832 chr7:134001865 SLC35B4 0.43 6.57 0.34 1.93e-10 Mean platelet volume; CRC cis rs9381040 0.674 rs3747742 chr6:41162518 C/T cg03526776 chr6:41159608 TREML2 -0.41 -7.29 -0.37 2.3e-12 Alzheimer's disease (late onset); CRC cis rs1832871 0.711 rs9459829 chr6:158680799 C/T cg07165851 chr6:158734300 TULP4 0.61 7.72 0.39 1.37e-13 Height; CRC cis rs995000 0.535 rs12239736 chr1:63085997 T/A cg19896129 chr1:63156450 NA 0.42 6.33 0.33 8.1e-10 Triglyceride levels; CRC cis rs3096299 0.658 rs4785679 chr16:89566113 G/T cg08392591 chr16:89556376 ANKRD11 0.43 5.82 0.31 1.43e-8 Multiple myeloma (IgH translocation); CRC cis rs34172651 0.876 rs11074653 chr16:24795959 C/T cg06028605 chr16:24865363 SLC5A11 0.44 7.9 0.4 4.11e-14 Intelligence (multi-trait analysis); CRC cis rs7937682 0.961 rs17113227 chr11:111620491 A/G cg09085632 chr11:111637200 PPP2R1B -1.06 -21.47 -0.76 1.46e-64 Primary sclerosing cholangitis; CRC cis rs10979 1.000 rs9373394 chr6:143890776 A/G cg25407410 chr6:143891975 LOC285740 -0.82 -13.4 -0.59 5.5e-33 Hypospadias; CRC cis rs9916302 0.904 rs11078897 chr17:37415870 C/T cg03013999 chr17:37608204 MED1 0.48 7.57 0.39 3.75e-13 Glomerular filtration rate (creatinine); CRC cis rs4665809 1.000 rs4665306 chr2:26319124 C/T cg22920501 chr2:26401640 FAM59B -0.53 -7.23 -0.37 3.4e-12 Gut microbiome composition (summer); CRC cis rs7772486 0.754 rs9386134 chr6:146145508 G/A cg23711669 chr6:146136114 FBXO30 0.78 13.59 0.6 1.04e-33 Lobe attachment (rater-scored or self-reported); CRC cis rs4665809 0.652 rs10779956 chr2:26405985 A/G cg27170947 chr2:26402098 FAM59B -0.59 -7.45 -0.38 8.42e-13 Gut microbiome composition (summer); CRC cis rs2032447 0.966 rs7756117 chr6:26046565 A/G cg18357526 chr6:26021779 HIST1H4A -0.71 -11.09 -0.52 1.76e-24 Intelligence (multi-trait analysis); CRC trans rs1973993 0.567 rs2800431 chr1:97000998 C/T cg10631902 chr5:14652156 NA 0.5 9.23 0.45 3.35e-18 Weight; CRC cis rs904251 0.772 rs1224127 chr6:37417556 G/A cg25019722 chr6:37503610 NA -0.42 -6.88 -0.35 3.06e-11 Cognitive performance; CRC cis rs6500395 0.963 rs2041921 chr16:48714002 T/C cg04672837 chr16:48644449 N4BP1 -0.44 -6.31 -0.33 9.05e-10 Response to tocilizumab in rheumatoid arthritis; CRC cis rs860295 0.702 rs10908471 chr1:155542942 A/G cg02153340 chr1:155202674 NA -0.58 -6.75 -0.35 6.59e-11 Body mass index; CRC trans rs3857536 0.566 rs208463 chr6:66913962 T/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.64 -8.72 -0.43 1.4e-16 Blood trace element (Cu levels); CRC cis rs2952156 1.000 rs1565923 chr17:37858678 A/G cg20243544 chr17:37824526 PNMT 0.56 8.53 0.43 5.39e-16 Asthma; CRC trans rs11098499 0.866 rs7677068 chr4:120291704 C/T cg25214090 chr10:38739885 LOC399744 0.61 9.66 0.47 1.39e-19 Corneal astigmatism; CRC trans rs208520 0.754 rs851593 chr6:66875783 C/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 1.02 14.21 0.62 4.54e-36 Exhaled nitric oxide output; CRC cis rs2797160 1.000 rs1739374 chr6:126011825 C/T cg05901451 chr6:126070800 HEY2 0.39 6.02 0.32 4.54e-9 Endometrial cancer; CRC trans rs867371 0.519 rs1566559 chr15:82524461 T/C cg04831495 chr15:85060580 GOLGA6L5 -0.39 -6.08 -0.32 3.32e-9 Cognitive ability;Cognitive ability (multi-trait analysis); CRC cis rs7786877 0.680 rs28584500 chr7:100216341 G/A cg16850897 chr7:100343110 ZAN -0.51 -6.23 -0.32 1.41e-9 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs17767392 0.846 rs4899394 chr14:71773497 C/T cg13720639 chr14:72061746 SIPA1L1 -0.45 -6.04 -0.32 4.09e-9 Mitral valve prolapse; CRC cis rs898097 0.578 rs2380173 chr17:80909157 G/T cg15664640 chr17:80829946 TBCD -0.47 -7.83 -0.4 6.67e-14 Breast cancer; CRC cis rs13191362 0.935 rs4273664 chr6:162955494 T/G cg06582575 chr6:163149167 PACRG;PARK2 0.8 9.94 0.48 1.54e-20 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC trans rs10982213 0.830 rs2274163 chr9:117188714 C/T cg23439141 chr13:113951774 LAMP1 0.39 6.15 0.32 2.29e-9 Interleukin-6 levels; CRC cis rs2404602 0.692 rs1471780 chr15:77026526 T/C cg03037974 chr15:76606532 NA 0.69 11.95 0.55 1.36e-27 Blood metabolite levels; CRC cis rs4862750 0.872 rs13110072 chr4:187878524 A/G cg07414643 chr4:187882934 NA 0.39 6.82 0.35 4.47e-11 Lobe attachment (rater-scored or self-reported); CRC cis rs17270561 0.609 rs4711100 chr6:25741954 G/A cg17691542 chr6:26056736 HIST1H1C 0.72 9.24 0.45 3.07e-18 Iron status biomarkers; CRC cis rs9814567 1.000 rs55913793 chr3:134285968 G/T cg06541857 chr3:134203789 ANAPC13;CEP63 -0.4 -5.98 -0.31 5.95e-9 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs6674970 1.000 rs6676190 chr1:151079317 C/T cg11822372 chr1:151115635 SEMA6C 0.53 7.54 0.38 4.48e-13 Childhood ear infection; CRC cis rs898097 0.578 rs8069697 chr17:80908110 T/C cg15664640 chr17:80829946 TBCD 0.47 7.87 0.4 5.31e-14 Breast cancer; CRC cis rs1577917 1.000 rs12665321 chr6:86769289 C/A cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.58 -7.07 -0.36 9.19e-12 Response to antipsychotic treatment; CRC cis rs1865760 0.929 rs12195653 chr6:25958621 A/G cg17691542 chr6:26056736 HIST1H1C 0.56 8.4 0.42 1.34e-15 Height; CRC cis rs921968 0.541 rs485975 chr2:219374250 C/T cg02176678 chr2:219576539 TTLL4 0.55 8.78 0.44 9.33e-17 Mean corpuscular hemoglobin concentration; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg14657818 chr2:8822058 ID2 0.45 6.24 0.33 1.36e-9 Anxiety disorder; CRC cis rs910316 1.000 rs175492 chr14:75545220 A/C cg08847533 chr14:75593920 NEK9 0.85 15.86 0.66 1.74e-42 Height; CRC cis rs4481887 0.962 rs6663952 chr1:248465682 A/G cg00666640 chr1:248458726 OR2T12 0.52 9.14 0.45 6.57e-18 Common traits (Other); CRC cis rs9491140 0.539 rs12210199 chr6:124684045 C/A cg19267163 chr6:125004984 NKAIN2 0.49 6.59 0.34 1.73e-10 Neuroticism; CRC cis rs7618915 0.547 rs4687548 chr3:52666650 A/T cg07507251 chr3:52567010 NT5DC2 0.42 5.98 0.31 5.97e-9 Bipolar disorder; CRC cis rs7666738 0.830 rs11727235 chr4:98946331 T/C cg05340658 chr4:99064831 C4orf37 0.61 9.54 0.47 3.45e-19 Colonoscopy-negative controls vs population controls; CRC trans rs12744310 0.887 rs12728217 chr1:41798269 C/T cg19175123 chr10:103411746 FBXW4 0.44 5.99 0.31 5.61e-9 Cognitive ability (multi-trait analysis);Intelligence;Cognitive ability; CRC cis rs7762018 0.891 rs3749882 chr6:170151766 C/T cg24289452 chr6:170231220 NA -0.56 -6.31 -0.33 9.03e-10 Thiazide-induced adverse metabolic effects in hypertensive patients; CRC trans rs7937682 0.883 rs659529 chr11:111436896 T/A cg18187862 chr3:45730750 SACM1L 0.45 6.38 0.33 6.06e-10 Primary sclerosing cholangitis; CRC cis rs896854 0.654 rs13278601 chr8:95972974 G/C cg23172400 chr8:95962367 TP53INP1 -0.48 -8.14 -0.41 8.01e-15 Type 2 diabetes; CRC cis rs9926296 0.744 rs154656 chr16:89708003 T/A cg01097406 chr16:89675127 NA 0.5 9.05 0.45 1.27e-17 Vitiligo; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg22350171 chr1:228675139 RNF187 0.41 6.86 0.35 3.5e-11 Liver disease severity in Alagille syndrome; CRC trans rs1997103 1.000 rs12718956 chr7:55407763 A/G cg20935933 chr6:143382018 AIG1 0.51 6.65 0.34 1.25e-10 QRS interval (sulfonylurea treatment interaction); CRC cis rs7208859 0.623 rs58908911 chr17:29244558 C/T cg01831904 chr17:28903510 LRRC37B2 -0.57 -5.93 -0.31 7.57e-9 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs5750830 0.649 rs5750813 chr22:39795228 G/C cg24399712 chr22:39784796 NA -0.49 -9.5 -0.46 4.51e-19 Intelligence (multi-trait analysis); CRC cis rs7772486 0.875 rs2748483 chr6:146335560 A/T cg23711669 chr6:146136114 FBXO30 -0.64 -10.8 -0.51 1.78e-23 Lobe attachment (rater-scored or self-reported); CRC cis rs2980439 0.846 rs2980437 chr8:8094763 C/T cg08975724 chr8:8085496 FLJ10661 -0.5 -7.88 -0.4 4.9e-14 Neuroticism; CRC cis rs1953600 1.000 rs2789679 chr10:81907884 A/T cg04850286 chr10:81895943 PLAC9 -0.38 -6.83 -0.35 4.2e-11 Sarcoidosis; CRC cis rs1707322 1.000 rs1768800 chr1:46549188 A/G cg03146154 chr1:46216737 IPP -0.52 -7.18 -0.37 4.54e-12 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs1401999 1.000 rs2176824 chr3:183654029 C/G cg01324343 chr3:183735012 ABCC5 0.82 14.95 0.64 6.37e-39 Anterior chamber depth; CRC cis rs3858526 0.839 rs10466484 chr11:5943696 A/G cg13902645 chr11:5959945 NA -0.6 -8.39 -0.42 1.44e-15 DNA methylation (variation); CRC cis rs853679 0.517 rs9380052 chr6:28064623 A/G cg23161317 chr6:28129485 ZNF389 0.48 5.8 0.3 1.58e-8 Depression; CRC cis rs4692589 0.531 rs12650424 chr4:170975204 T/C cg19918862 chr4:170955249 NA 0.49 6.43 0.33 4.46e-10 Anxiety disorder; CRC cis rs11098499 0.710 rs4145952 chr4:120155806 C/A cg09307838 chr4:120376055 NA 0.57 9.01 0.44 1.73e-17 Corneal astigmatism; CRC cis rs883565 0.569 rs1274972 chr3:39161456 G/A cg01426195 chr3:39028469 NA -0.42 -7.0 -0.36 1.4e-11 Handedness; CRC cis rs2179367 0.959 rs9373592 chr6:149733255 A/T cg16235748 chr6:149772707 ZC3H12D -0.36 -5.76 -0.3 1.94e-8 Dupuytren's disease; CRC cis rs7615952 0.512 rs4234285 chr3:125404477 G/A cg11143507 chr3:125485238 NA -0.57 -7.35 -0.38 1.56e-12 Blood pressure (smoking interaction); CRC cis rs1832871 0.521 rs62437411 chr6:158823211 G/A cg07165851 chr6:158734300 TULP4 0.45 5.91 0.31 8.63e-9 Height; CRC cis rs12497850 0.931 rs6791542 chr3:48787219 A/G cg07636037 chr3:49044803 WDR6 1.01 17.76 0.7 5.64e-50 Parkinson's disease; CRC cis rs6502050 0.835 rs8078795 chr17:80126320 C/T cg25804541 chr17:80189381 SLC16A3 -0.31 -5.95 -0.31 6.89e-9 Life satisfaction; CRC cis rs7618501 0.699 rs1317154 chr3:49910084 T/C cg24110177 chr3:50126178 RBM5 -0.47 -6.87 -0.35 3.2e-11 Intelligence (multi-trait analysis); CRC cis rs1048238 0.605 rs1889785 chr1:16348729 G/A cg22431228 chr1:16359049 CLCNKA -0.42 -8.62 -0.43 2.78e-16 Systolic blood pressure; CRC cis rs28386778 0.897 rs1043127 chr17:61791210 T/G cg23090583 chr17:61904693 PSMC5;FTSJ3 1.03 19.01 0.72 6.89e-55 Prudent dietary pattern; CRC cis rs6089584 0.888 rs6061982 chr20:60620673 C/T cg06108461 chr20:60628389 TAF4 -0.92 -15.85 -0.66 1.98e-42 Body mass index; CRC cis rs72945132 0.882 rs7943547 chr11:70133282 C/A cg14191688 chr11:70257035 CTTN 0.4 5.62 0.3 4.07e-8 Coronary artery disease; CRC cis rs4363385 0.818 rs572821 chr1:153008276 G/A cg25856811 chr1:152973957 SPRR3 -0.25 -6.99 -0.36 1.51e-11 Inflammatory skin disease; CRC cis rs651907 0.535 rs11707250 chr3:101509371 A/T cg12386194 chr3:101231763 SENP7 -0.53 -7.55 -0.38 4.38e-13 Colorectal cancer; CRC cis rs13082711 0.555 rs7627508 chr3:27252495 A/C cg02860705 chr3:27208620 NA 0.69 9.73 0.47 7.59e-20 Systolic blood pressure;Diastolic blood pressure;Blood pressure; CRC cis rs1005277 0.528 rs2057228 chr10:38515766 T/C cg17219203 chr10:38645113 HSD17B7P2 -0.41 -5.92 -0.31 8.11e-9 Extrinsic epigenetic age acceleration; CRC cis rs490234 0.812 rs12553699 chr9:128294526 C/G cg14078157 chr9:128172775 NA -0.4 -6.8 -0.35 5.07e-11 Mean arterial pressure; CRC cis rs9513627 0.573 rs4771336 chr13:100210610 T/G cg15490075 chr13:100150979 NA 0.49 6.17 0.32 2.02e-9 Obesity-related traits; CRC cis rs6743376 0.556 rs3820738 chr2:113819439 A/G cg24553058 chr2:113831203 IL1F10 0.39 6.47 0.34 3.55e-10 Inflammatory biomarkers; CRC cis rs7769051 1.000 rs9493443 chr6:133121349 C/T cg07930552 chr6:133119739 C6orf192 0.63 7.74 0.39 1.24e-13 Type 2 diabetes nephropathy; CRC cis rs6496667 1.000 rs6496666 chr15:90891662 T/C cg04176472 chr15:90893244 GABARAPL3 0.57 8.81 0.44 7.13e-17 Rheumatoid arthritis; CRC cis rs9435341 0.965 rs1762485 chr1:107625056 C/T cg11070056 chr1:107600091 PRMT6 -0.4 -5.74 -0.3 2.1e-8 Facial morphology (factor 21, depth of nasal alae); CRC cis rs6570726 0.791 rs447992 chr6:145817184 C/T cg13319975 chr6:146136371 FBXO30 -0.44 -6.66 -0.34 1.13e-10 Lobe attachment (rater-scored or self-reported); CRC cis rs2252521 0.524 rs719675 chr7:29041931 C/G cg11728747 chr7:29037910 CPVL -0.49 -7.08 -0.36 8.94e-12 Cognitive performance; CRC cis rs769267 1.000 rs12985655 chr19:19442434 G/A cg02546618 chr19:19431379 KIAA0892;SF4 -0.46 -6.46 -0.34 3.85e-10 Tonsillectomy; CRC cis rs11628318 0.660 rs8009475 chr14:103058608 A/G cg12046867 chr14:103022105 NA -0.77 -9.16 -0.45 5.82e-18 Platelet count; CRC cis rs2070488 1.000 rs4147025 chr3:38456531 C/T cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.9 16.19 0.67 9.15e-44 Electrocardiographic conduction measures; CRC cis rs2882667 0.690 rs825677 chr5:138104770 T/C cg09476006 chr5:138032270 NA -0.56 -9.54 -0.47 3.28e-19 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs6840360 1.000 rs2007218 chr4:152643972 A/G cg09659197 chr4:152720779 NA -0.51 -10.91 -0.52 7.18e-24 Intelligence (multi-trait analysis); CRC cis rs6461049 0.734 rs1558465 chr7:2151398 G/C cg08027265 chr7:2291960 NA -0.36 -6.22 -0.32 1.51e-9 Schizophrenia; CRC cis rs2952156 0.959 rs2941504 chr17:37830900 A/G cg20243544 chr17:37824526 PNMT 0.54 8.25 0.41 3.87e-15 Asthma; CRC cis rs1799949 0.965 rs799910 chr17:41279561 G/C cg23758822 chr17:41437982 NA 0.93 18.98 0.72 9.12e-55 Menopause (age at onset); CRC cis rs6088580 0.543 rs4911158 chr20:33239512 T/C cg08999081 chr20:33150536 PIGU -0.36 -5.61 -0.3 4.39e-8 Glomerular filtration rate (creatinine); CRC cis rs9584850 0.540 rs17574536 chr13:99171040 G/A cg20487152 chr13:99095054 FARP1 0.45 5.84 0.31 1.23e-8 Neuroticism; CRC cis rs9837602 0.507 rs793452 chr3:99529523 C/T cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G 0.48 6.4 0.33 5.41e-10 Breast cancer; CRC cis rs7119 0.667 rs907392 chr15:77903393 T/C cg27398640 chr15:77910606 LINGO1 0.41 7.55 0.38 4.25e-13 Type 2 diabetes; CRC cis rs8103278 1.000 rs7258283 chr19:46335511 C/T cg20908204 chr19:46285434 DMPK -0.35 -6.78 -0.35 5.64e-11 Coronary artery disease; CRC cis rs9611565 0.512 rs5996063 chr22:42168767 G/A cg06634786 chr22:41940651 POLR3H 0.68 7.52 0.38 5.14e-13 Vitiligo; CRC cis rs2072499 0.966 rs2842882 chr1:156165342 T/G cg25208724 chr1:156163844 SLC25A44 1.1 26.74 0.83 1.69e-84 Testicular germ cell tumor; CRC cis rs2404602 0.692 rs3816266 chr15:76993835 T/G cg22467129 chr15:76604101 ETFA -0.41 -6.87 -0.35 3.16e-11 Blood metabolite levels; CRC cis rs4843747 0.573 rs7499959 chr16:88110422 C/G cg03395651 chr16:88107091 BANP 0.5 6.75 0.35 6.5500000000000006e-11 Menopause (age at onset); CRC cis rs9648716 1.000 rs7776491 chr7:140605067 C/T cg10747023 chr7:140774559 NA 0.45 5.89 0.31 9.29e-9 Type 2 diabetes; CRC cis rs10504229 0.683 rs7459958 chr8:58111905 G/T cg02290350 chr8:58132656 NA -0.6 -8.3 -0.42 2.8e-15 Developmental language disorder (linguistic errors); CRC cis rs113835537 0.935 rs117131621 chr11:66422334 C/T cg22134325 chr11:66188745 NPAS4 0.41 6.73 0.35 7.51e-11 Airway imaging phenotypes; CRC cis rs3823572 0.542 rs61286514 chr7:133630693 G/A cg03336402 chr7:133662267 EXOC4 0.67 10.32 0.49 8.37e-22 Intelligence (multi-trait analysis); CRC cis rs12476592 0.602 rs262528 chr2:63903367 C/T cg10828910 chr2:63850056 LOC388955 0.51 6.33 0.33 7.99e-10 Childhood ear infection; CRC cis rs2839186 0.934 rs13046494 chr21:47707430 A/C cg02776659 chr21:47717406 C21orf57 -0.34 -5.62 -0.3 4.13e-8 Testicular germ cell tumor; CRC cis rs7666738 0.791 rs60028147 chr4:99046618 G/A cg05340658 chr4:99064831 C4orf37 0.58 8.91 0.44 3.6e-17 Colonoscopy-negative controls vs population controls; CRC cis rs9467711 0.606 rs2393667 chr6:26421345 T/C cg16898833 chr6:26189333 HIST1H4D 0.89 7.28 0.37 2.4e-12 Autism spectrum disorder or schizophrenia; CRC cis rs4689388 0.929 rs1046320 chr4:6304344 C/T cg00701064 chr4:6280414 WFS1 0.66 10.99 0.52 3.79e-24 Type 2 diabetes and other traits;Type 2 diabetes; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg01141252 chr19:45251925 BCL3 0.47 6.56 0.34 2.13e-10 Response to antipsychotic treatment; CRC cis rs8060686 0.858 rs20549 chr16:67969930 A/G cg07125278 chr16:67683757 RLTPR -0.46 -6.01 -0.31 4.91e-9 HDL cholesterol;Metabolic syndrome; CRC cis rs1865760 0.566 rs9467672 chr6:26083904 C/T cg16482183 chr6:26056742 HIST1H1C 0.52 7.5 0.38 6.17e-13 Height; CRC cis rs2120019 0.938 rs35911108 chr15:75322179 G/A cg17294928 chr15:75287854 SCAMP5 -0.77 -11.15 -0.52 1.03e-24 Blood trace element (Zn levels); CRC trans rs2727020 0.575 rs10769587 chr11:49549849 C/G cg11707556 chr5:10655725 ANKRD33B -0.4 -7.5 -0.38 6.16e-13 Coronary artery disease; CRC cis rs2732480 0.577 rs2634691 chr12:48708259 G/T cg21466736 chr12:48725269 NA -0.61 -9.04 -0.45 1.34e-17 Hemoglobin concentration;Red blood cell count;Hematocrit; CRC trans rs11148252 0.766 rs74697307 chr13:52897573 C/T cg18335740 chr13:41363409 SLC25A15 -0.55 -8.39 -0.42 1.48e-15 Lewy body disease; CRC cis rs1448094 0.556 rs11610789 chr12:86169541 A/G cg02569458 chr12:86230093 RASSF9 0.5 8.22 0.41 4.69e-15 Major depressive disorder; CRC cis rs853679 0.517 rs9380062 chr6:28137569 G/A cg21251018 chr6:28226885 NKAPL 0.48 6.17 0.32 2.02e-9 Depression; CRC cis rs10905065 1.000 rs10905065 chr10:5769827 C/T cg11519256 chr10:5708881 ASB13 0.49 7.21 0.37 3.86e-12 Menopause (age at onset); CRC cis rs17270561 0.636 rs9393671 chr6:25789189 G/C cg17691542 chr6:26056736 HIST1H1C -0.52 -7.09 -0.36 8.45e-12 Iron status biomarkers; CRC cis rs4509693 1.000 rs4917908 chr10:102502674 G/C cg23167259 chr10:102495509 NA -0.49 -6.76 -0.35 6.28e-11 Alzheimer's disease; CRC cis rs6921919 0.583 rs11755942 chr6:28369537 A/G cg21251018 chr6:28226885 NKAPL 0.39 5.82 0.31 1.37e-8 Autism spectrum disorder or schizophrenia; CRC cis rs10221833 0.602 rs355889 chr2:165634651 C/T cg03182029 chr2:165697222 COBLL1 0.52 6.09 0.32 3.22e-9 Response to statin therapy; CRC cis rs2243480 1.000 rs3885839 chr7:65290403 G/T cg18252515 chr7:66147081 NA -1.17 -13.23 -0.59 2.48e-32 Diabetic kidney disease; CRC cis rs9902453 0.967 rs7212741 chr17:28322941 G/A cg26525008 chr17:28256777 EFCAB5;SSH2 0.58 8.66 0.43 2.14e-16 Coffee consumption (cups per day); CRC cis rs7412746 0.611 rs10888394 chr1:150749913 C/T cg10589385 chr1:150898437 SETDB1 0.3 6.08 0.32 3.34e-9 Melanoma; CRC cis rs736408 0.774 rs4687551 chr3:52823448 C/T cg18404041 chr3:52824283 ITIH1 0.52 10.73 0.51 3.2e-23 Bipolar disorder; CRC trans rs3780486 0.846 rs7873903 chr9:33142728 G/A cg04842962 chr6:43655489 MRPS18A 1.17 24.31 0.8 1.87e-75 IgG glycosylation; CRC cis rs2836974 0.897 rs2026265 chr21:40595517 G/A cg06238570 chr21:40685208 BRWD1 0.78 10.89 0.51 8.51e-24 Cognitive function; CRC cis rs8044868 0.530 rs9928157 chr16:72117073 T/C cg23815491 chr16:72088622 HP 0.47 6.81 0.35 4.78e-11 Body mass index (change over time) in cancer or chronic obstructive pulmonary disease;Body mass index (change over time) in cancer; CRC cis rs7095944 0.585 rs11245357 chr10:126452042 A/G cg08799069 chr10:126477246 METTL10 -0.44 -6.89 -0.35 2.93e-11 Asthma; CRC cis rs11098499 0.569 rs10023641 chr4:120258410 C/G cg09307838 chr4:120376055 NA 0.6 9.55 0.47 3.16e-19 Corneal astigmatism; CRC cis rs9341808 0.718 rs9352801 chr6:80817468 G/T cg08355045 chr6:80787529 NA 0.43 6.88 0.35 2.95e-11 Sitting height ratio; CRC cis rs2243480 1.000 rs2707844 chr7:66059509 G/A cg25985355 chr7:65971099 NA -0.52 -5.97 -0.31 6.08e-9 Diabetic kidney disease; CRC cis rs1882538 0.569 rs11562037 chr7:133076885 A/G cg10665199 chr7:133106180 EXOC4 0.68 10.78 0.51 2.08e-23 Intelligence (multi-trait analysis); CRC cis rs11650494 0.908 rs77247327 chr17:47411493 T/C cg08112188 chr17:47440006 ZNF652 1.26 11.71 0.54 1.03e-26 Prostate cancer; CRC cis rs8141529 0.732 rs6005872 chr22:29172898 T/G cg02153584 chr22:29168773 CCDC117 0.54 8.16 0.41 7.4e-15 Lymphocyte counts; CRC cis rs5769765 0.862 rs138857 chr22:50199589 C/T cg08270630 chr22:50330655 NA -0.41 -5.98 -0.31 5.85e-9 Schizophrenia; CRC cis rs6502050 0.835 rs67634087 chr17:80118168 C/T cg22110888 chr17:80059540 CCDC57 0.42 6.61 0.34 1.58e-10 Life satisfaction; CRC cis rs1552244 1.000 rs2272123 chr3:10140115 G/A cg00166722 chr3:10149974 C3orf24 0.69 9.36 0.46 1.32e-18 Alzheimer's disease; CRC cis rs7901135 0.962 rs9416746 chr10:60573753 G/T cg23799393 chr10:60588674 BICC1 0.37 5.75 0.3 2.02e-8 Morning vs. evening chronotype; CRC cis rs6582630 0.555 rs34730221 chr12:38405140 C/T cg13010199 chr12:38710504 ALG10B -0.46 -6.63 -0.34 1.38e-10 Drug-induced liver injury (flucloxacillin); CRC cis rs546131 0.928 rs516228 chr11:34838823 C/T cg11058730 chr11:34937778 PDHX;APIP 0.49 7.2 0.37 4.11e-12 Lung disease severity in cystic fibrosis; CRC cis rs9611565 0.512 rs1534932 chr22:42150146 C/T cg06634786 chr22:41940651 POLR3H 0.61 6.56 0.34 2.05e-10 Vitiligo; CRC cis rs9467711 0.606 rs9358930 chr6:26357011 C/T cg14345882 chr6:26364793 BTN3A2 0.64 5.63 0.3 3.85e-8 Autism spectrum disorder or schizophrenia; CRC cis rs4692589 0.556 rs2279267 chr4:170990053 A/G cg19918862 chr4:170955249 NA -0.47 -6.52 -0.34 2.64e-10 Anxiety disorder; CRC cis rs7107770 1.000 rs34140247 chr11:125092360 G/A cg27629782 chr11:125073726 PKNOX2 0.44 5.67 0.3 3.05e-8 Photic sneeze reflex; CRC cis rs57221529 0.709 rs72706611 chr5:561146 C/A cg09021430 chr5:549028 NA -0.72 -8.15 -0.41 7.73e-15 Lung disease severity in cystic fibrosis; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg08365438 chr10:21683093 NA -0.38 -6.0 -0.31 5.18e-9 Liver disease severity in Alagille syndrome; CRC cis rs7487075 0.859 rs956910 chr12:46759788 A/G cg22049899 chr12:47219821 SLC38A4 0.35 6.92 0.36 2.44e-11 Itch intensity from mosquito bite; CRC cis rs75422866 0.717 rs73104143 chr12:48087232 C/A cg14736327 chr12:48174669 SLC48A1 -0.79 -6.01 -0.31 4.92e-9 Pneumonia; CRC cis rs2882667 0.654 rs700626 chr5:138117938 A/G cg09476006 chr5:138032270 NA -0.57 -9.77 -0.47 5.69e-20 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs853679 0.517 rs2281588 chr6:28072602 G/A cg12273811 chr6:28175739 NA 0.74 9.41 0.46 8.58e-19 Depression; CRC cis rs4563143 0.647 rs117946634 chr19:29256822 G/T cg12756686 chr19:29218302 NA 0.6 8.96 0.44 2.38e-17 Methadone dose in opioid dependence; CRC cis rs4713118 0.527 rs36042294 chr6:27720712 C/G cg08798685 chr6:27730294 NA -0.4 -6.02 -0.32 4.56e-9 Parkinson's disease; CRC cis rs6762477 0.748 rs34877766 chr3:50234126 A/G cg05623727 chr3:50126028 RBM5 0.41 6.8 0.35 4.81e-11 Menarche (age at onset); CRC cis rs1971762 0.563 rs3897117 chr12:54077407 T/G cg06632207 chr12:54070931 ATP5G2 0.41 7.03 0.36 1.18e-11 Height; CRC cis rs9322193 0.923 rs7767622 chr6:150002902 T/C cg05861140 chr6:150128134 PCMT1 -0.36 -5.85 -0.31 1.18e-8 Lung cancer; CRC cis rs9388451 0.839 rs4897157 chr6:126102981 A/T cg05901451 chr6:126070800 HEY2 -0.65 -11.17 -0.52 8.86e-25 Brugada syndrome; CRC cis rs2292884 0.505 rs77856818 chr2:238402830 G/A cg08992911 chr2:238395768 MLPH 0.61 6.13 0.32 2.53e-9 Prostate cancer; CRC cis rs9837602 1.000 rs35844878 chr3:99796626 T/C cg07805332 chr3:99536008 MIR548G;C3orf26 -0.47 -6.19 -0.32 1.81e-9 Breast cancer; CRC cis rs77861329 0.748 rs2334961 chr3:52173625 G/C cg08692210 chr3:52188851 WDR51A 0.5 5.89 0.31 9.43e-9 Macrophage inflammatory protein 1b levels; CRC cis rs4862750 0.872 rs6830426 chr4:187897270 T/A cg06074448 chr4:187884817 NA -0.58 -10.81 -0.51 1.71e-23 Lobe attachment (rater-scored or self-reported); CRC cis rs1008375 0.931 rs1860592 chr4:17577028 C/G cg02297831 chr4:17616191 MED28 0.44 5.78 0.3 1.74e-8 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs10197940 0.550 rs77233070 chr2:152416477 G/A cg19508488 chr2:152266495 RIF1 0.54 7.37 0.38 1.41e-12 Lung cancer; CRC cis rs13256369 0.901 rs13251887 chr8:8568678 G/A cg06636001 chr8:8085503 FLJ10661 0.49 6.33 0.33 8.13e-10 Obesity-related traits; CRC cis rs4713118 0.869 rs9283881 chr6:27715255 A/T cg26587870 chr6:27730563 NA -0.43 -6.69 -0.35 9.61e-11 Parkinson's disease; CRC cis rs875971 0.660 rs1860470 chr7:66103694 G/C cg11764359 chr7:65958608 NA -0.54 -8.38 -0.42 1.53e-15 Aortic root size; CRC cis rs1799949 0.965 rs8176193 chr17:41231516 C/T cg05368731 chr17:41323189 NBR1 0.7 10.59 0.5 9.76e-23 Menopause (age at onset); CRC cis rs7264396 0.790 rs6060582 chr20:34313297 A/G cg04508476 chr20:34239394 CPNE1;RBM12 0.66 10.89 0.51 8.71e-24 Total cholesterol levels; CRC cis rs78456975 1.000 rs10205916 chr2:1558451 A/T cg01028140 chr2:1542097 TPO 0.58 6.07 0.32 3.48e-9 Placebo response in major depressive disorder (% change in symptom score); CRC cis rs7224685 0.501 rs781853 chr17:3953083 T/C cg21851534 chr17:3907994 ZZEF1 0.36 6.01 0.31 4.8e-9 Type 2 diabetes; CRC cis rs4604732 0.631 rs75320597 chr1:247626751 T/G cg12758973 chr1:247694275 LOC148824;OR2C3 0.42 6.14 0.32 2.32e-9 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CRC cis rs9611565 0.512 rs964899 chr22:42142386 G/A cg03806693 chr22:41940476 POLR3H 1.03 12.53 0.57 1.06e-29 Vitiligo; CRC cis rs9733 0.650 rs12125672 chr1:150554470 A/T cg17724175 chr1:150552817 MCL1 -0.5 -8.07 -0.41 1.32e-14 Tonsillectomy; CRC cis rs9611565 0.559 rs5758412 chr22:42080803 T/A cg06634786 chr22:41940651 POLR3H 0.61 6.86 0.35 3.38e-11 Vitiligo; CRC cis rs798554 0.610 rs1182209 chr7:2808595 C/T cg13628971 chr7:2884303 GNA12 0.43 6.5 0.34 2.99e-10 Height; CRC trans rs10506458 0.834 rs73125186 chr12:63373400 C/T cg22491629 chr6:157744540 C6orf35 -0.74 -8.33 -0.42 2.15e-15 Hemostatic factors and hematological phenotypes; CRC cis rs9311474 0.539 rs12489828 chr3:52567014 G/T cg08222913 chr3:52553049 STAB1 -0.41 -8.32 -0.42 2.38e-15 Electroencephalogram traits; CRC cis rs921968 0.643 rs711191 chr2:219386084 T/A cg02176678 chr2:219576539 TTLL4 0.48 8.0 0.4 2.1e-14 Mean corpuscular hemoglobin concentration; CRC cis rs8014204 0.604 rs2159906 chr14:75390912 G/T cg08847533 chr14:75593920 NEK9 0.5 7.12 0.37 6.72e-12 Caffeine consumption; CRC cis rs2949837 0.581 rs1542819 chr7:45978059 T/C cg21268650 chr7:45961089 IGFBP3 0.38 6.41 0.33 5.05e-10 Sitting height ratio; CRC cis rs561341 1.000 rs72823789 chr17:30284084 G/A cg00745463 chr17:30367425 LRRC37B -0.89 -9.78 -0.47 5.21e-20 Hip circumference adjusted for BMI; CRC cis rs875971 0.638 rs7793569 chr7:66116633 T/G cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.44 -6.46 -0.34 3.75e-10 Aortic root size; CRC trans rs3780486 0.713 rs3780489 chr9:33129844 G/T cg04842962 chr6:43655489 MRPS18A 1.16 25.92 0.82 1.73e-81 IgG glycosylation; CRC cis rs6141769 0.542 rs28612490 chr20:31297568 G/A cg13636640 chr20:31349939 DNMT3B -0.38 -5.74 -0.3 2.12e-8 Subjective well-being; CRC cis rs73200209 0.912 rs7969182 chr12:116612079 T/C cg01776926 chr12:116560359 MED13L -0.48 -5.84 -0.31 1.27e-8 Total body bone mineral density; CRC cis rs7553864 1.000 rs4551571 chr1:87614244 C/G cg02083836 chr1:87617350 LOC339524 0.37 6.59 0.34 1.76e-10 Smoking behavior; CRC cis rs9858542 0.953 rs7622302 chr3:49547561 T/C cg07274523 chr3:49395745 GPX1 0.47 6.4 0.33 5.33e-10 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs870825 0.616 rs7667449 chr4:185641711 T/C cg04058563 chr4:185651563 MLF1IP 0.74 9.66 0.47 1.33e-19 Blood protein levels; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg07031794 chr2:26568949 SELI;GPR113 0.38 6.59 0.34 1.76e-10 Liver disease severity in Alagille syndrome; CRC cis rs561341 0.941 rs4795664 chr17:30233467 C/T cg00745463 chr17:30367425 LRRC37B -0.73 -8.24 -0.41 4.2e-15 Hip circumference adjusted for BMI; CRC cis rs875971 1.000 rs7789768 chr7:65938980 A/C cg11764359 chr7:65958608 NA 0.62 9.91 0.48 1.96e-20 Aortic root size; CRC cis rs7259376 0.714 rs4358065 chr19:22521132 A/G cg02657401 chr19:22469223 NA -0.38 -8.49 -0.42 7.42e-16 Menopause (age at onset); CRC cis rs7584330 0.554 rs3751109 chr2:238427194 T/C cg08992911 chr2:238395768 MLPH 0.47 5.75 0.3 2.04e-8 Prostate cancer; CRC cis rs6964587 1.000 rs13239875 chr7:91716104 G/A cg17063962 chr7:91808500 NA 0.79 14.22 0.62 4.1e-36 Breast cancer; CRC cis rs11677370 0.574 rs10209122 chr2:3871186 C/A cg17052675 chr2:3827356 NA -0.68 -11.02 -0.52 2.91e-24 Type 2 diabetes; CRC cis rs10504229 0.683 rs2291765 chr8:58142874 C/T cg22535103 chr8:58192502 C8orf71 -0.62 -8.58 -0.43 3.81e-16 Developmental language disorder (linguistic errors); CRC cis rs3749237 0.595 rs4855873 chr3:49459114 A/C cg02487422 chr3:49467188 NICN1 0.42 6.87 0.35 3.19e-11 Resting heart rate; CRC trans rs3743266 0.613 rs2414669 chr15:60708824 A/G cg17512474 chr5:149546335 CDX1 0.22 6.23 0.32 1.43e-9 Menarche (age at onset); CRC cis rs644799 0.610 rs1255179 chr11:95472097 A/G cg03916912 chr11:95522834 CEP57;FAM76B 0.57 8.95 0.44 2.65e-17 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs25422 0.938 rs7356858 chr6:118765814 G/C cg15382696 chr6:118971807 C6orf204 0.6 7.67 0.39 1.9e-13 Renal cell carcinoma; CRC cis rs13082711 1.000 rs35944308 chr3:27536356 G/A cg02860705 chr3:27208620 NA 0.6 7.78 0.39 9.42e-14 Systolic blood pressure;Diastolic blood pressure;Blood pressure; CRC cis rs7208859 0.673 rs450585 chr17:28951039 G/A cg19761014 chr17:28927070 LRRC37B2 0.57 7.0 0.36 1.41e-11 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC trans rs1005277 0.505 rs200910 chr10:38108176 C/T cg17830980 chr10:43048298 ZNF37B -0.4 -6.3 -0.33 9.28e-10 Extrinsic epigenetic age acceleration; CRC cis rs9549328 0.589 rs36164841 chr13:113616579 A/G cg25790453 chr13:113633590 MCF2L 0.43 7.55 0.38 4.25e-13 Systolic blood pressure; CRC cis rs711245 0.573 rs11899523 chr2:36800918 T/C cg09467607 chr2:36825704 FEZ2 0.53 8.3 0.42 2.69e-15 Height; CRC cis rs6543140 0.964 rs2080288 chr2:103022166 G/A cg04239558 chr2:103089729 SLC9A4 0.36 6.16 0.32 2.11e-9 Blood protein levels; CRC cis rs3617 0.625 rs11715347 chr3:52883070 C/T cg05573699 chr3:52720067 GNL3;PBRM1 0.37 5.6 0.3 4.48e-8 Red blood cell count;Autism spectrum disorder or schizophrenia; CRC cis rs59918340 0.728 rs10112337 chr8:142233573 A/G cg17298326 chr8:142245477 NA 0.39 5.88 0.31 1.02e-8 Immature fraction of reticulocytes; CRC trans rs2303319 0.504 rs62189052 chr2:162623869 C/G cg12500891 chr11:57225987 NA -0.65 -6.05 -0.32 3.87e-9 Cognitive function; CRC trans rs747782 0.639 rs17198985 chr11:48183565 T/C cg03929089 chr4:120376271 NA 0.68 6.67 0.35 1.06e-10 Intraocular pressure; CRC cis rs820218 0.926 rs820135 chr17:73674977 T/C cg01973089 chr17:73647209 RECQL5 0.33 6.26 0.33 1.23e-9 Rotator cuff tears; CRC cis rs651907 0.557 rs62284198 chr3:101474699 G/A cg11279151 chr3:101281821 RG9MTD1 -0.48 -6.5 -0.34 3.02e-10 Colorectal cancer; CRC cis rs7959452 0.640 rs1598543 chr12:69688757 G/T cg14784868 chr12:69753453 YEATS4 0.75 11.99 0.55 9.62e-28 Blood protein levels; CRC cis rs2257205 0.667 rs7342862 chr17:56816561 A/G cg25885038 chr17:56607967 SEPT4 -0.53 -5.75 -0.3 2.07e-8 Pancreatic cancer; CRC cis rs4664293 0.585 rs34385495 chr2:160512883 T/C cg08347373 chr2:160653686 CD302 0.39 6.59 0.34 1.71e-10 Monocyte percentage of white cells; CRC trans rs2303319 0.504 rs62188988 chr2:162531068 T/C cg15664909 chr17:685709 GLOD4;RNMTL1 -0.7 -6.31 -0.33 8.85e-10 Cognitive function; CRC cis rs9435341 0.930 rs12408634 chr1:107579540 G/A cg14671364 chr1:107599128 PRMT6 0.6 8.07 0.41 1.33e-14 Facial morphology (factor 21, depth of nasal alae); CRC cis rs977987 0.806 rs34996006 chr16:75479434 A/G cg03315344 chr16:75512273 CHST6 0.57 9.7 0.47 9.94e-20 Dupuytren's disease; CRC trans rs875971 0.545 rs6460298 chr7:65907770 T/C cg02869306 chr7:64672164 INTS4L1 -0.43 -6.22 -0.32 1.48e-9 Aortic root size; CRC cis rs9648716 1.000 rs1267616 chr7:140514131 A/G cg10747023 chr7:140774559 NA 0.46 5.92 0.31 7.94e-9 Type 2 diabetes; CRC cis rs7274811 0.744 rs209677 chr20:32140287 C/T cg03904042 chr20:32255491 NECAB3;C20orf134 0.5 7.26 0.37 2.83e-12 Height; CRC cis rs7772486 0.651 rs1292338 chr6:145967471 A/C cg13319975 chr6:146136371 FBXO30 0.42 6.22 0.32 1.49e-9 Lobe attachment (rater-scored or self-reported); CRC trans rs4698169 0.510 rs675984 chr4:17123821 A/G cg21465176 chr17:80358876 C17orf101 -0.51 -6.97 -0.36 1.72e-11 Temperament (bipolar disorder); CRC cis rs11190604 1.000 rs2495741 chr10:102331795 A/G cg16342193 chr10:102329863 NA -0.33 -5.78 -0.3 1.72e-8 Palmitoleic acid (16:1n-7) levels; CRC cis rs7044106 0.762 rs10739570 chr9:123381222 C/T cg14255062 chr9:123606675 PSMD5;LOC253039 0.44 6.7 0.35 9.12e-11 Hip circumference adjusted for BMI; CRC cis rs7178572 0.568 rs11632966 chr15:77621805 A/C cg22256960 chr15:77711686 NA -0.66 -9.58 -0.47 2.47e-19 Type 2 diabetes; CRC cis rs9322817 0.691 rs2499667 chr6:105319125 G/A cg02098413 chr6:105308735 HACE1 0.43 8.49 0.42 7.27e-16 Thyroid stimulating hormone; CRC cis rs4711336 1.000 rs2296742 chr6:33659793 G/A cg14003231 chr6:33640908 ITPR3 0.46 7.36 0.38 1.5e-12 Height; CRC cis rs11148252 0.538 rs2296348 chr13:52710136 T/G cg12458913 chr13:53173898 NA 0.43 6.37 0.33 6.51e-10 Lewy body disease; CRC trans rs11039798 0.614 rs8188910 chr11:48825740 C/T cg03929089 chr4:120376271 NA 0.63 6.01 0.31 4.92e-9 Axial length; CRC cis rs853679 0.599 rs149990 chr6:27998258 G/A cg15845792 chr6:28175446 NA 0.71 6.59 0.34 1.77e-10 Depression; CRC cis rs11690935 0.632 rs9789538 chr2:172618474 G/C cg13550731 chr2:172543902 DYNC1I2 0.65 9.65 0.47 1.43e-19 Schizophrenia; CRC cis rs11864453 0.614 rs12445586 chr16:72126276 C/T cg23815491 chr16:72088622 HP 0.51 7.69 0.39 1.72e-13 Fibrinogen levels; CRC cis rs11711311 0.822 rs9850256 chr3:113408382 T/C cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.46 -6.17 -0.32 2.02e-9 IgG glycosylation; CRC cis rs6543140 0.964 rs13383602 chr2:103085962 C/T cg03938978 chr2:103052716 IL18RAP 0.41 6.52 0.34 2.71e-10 Blood protein levels; CRC cis rs514406 0.661 rs562641 chr1:53374666 C/T cg27535305 chr1:53392650 SCP2 -0.44 -7.72 -0.39 1.44e-13 Monocyte count; CRC cis rs875971 0.862 rs778724 chr7:65829291 T/C cg00343986 chr7:65444356 GUSB 0.41 5.87 0.31 1.08e-8 Aortic root size; CRC cis rs765787 0.556 rs10851422 chr15:45513738 T/C cg24006582 chr15:45444508 DUOX1 0.53 7.69 0.39 1.76e-13 Uric acid levels; CRC cis rs11123610 0.520 rs66646194 chr2:3720420 G/A cg25251562 chr2:3704773 ALLC -0.49 -6.14 -0.32 2.34e-9 Response to inhaled corticosteroid treatment in asthma (change in FEV1); CRC cis rs12908161 0.959 rs3748376 chr15:85328352 C/T cg17507749 chr15:85114479 UBE2QP1 0.62 8.8 0.44 7.98e-17 Schizophrenia; CRC trans rs7395662 0.591 rs4882093 chr11:48530820 G/A cg00717180 chr2:96193071 NA -0.37 -6.1 -0.32 2.94e-9 HDL cholesterol; CRC cis rs9910055 0.607 rs13726 chr17:42239561 C/T cg16434002 chr17:42200994 HDAC5 -0.48 -6.61 -0.34 1.52e-10 Total body bone mineral density; CRC cis rs941898 0.541 rs1951486 chr14:100607360 C/T cg26002632 chr14:100625216 DEGS2 0.32 5.68 0.3 2.99e-8 White matter hyperintensity burden; CRC cis rs11971779 0.584 rs6962029 chr7:139034719 T/C cg07862535 chr7:139043722 LUC7L2 0.56 7.29 0.37 2.25e-12 Diisocyanate-induced asthma; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg14751914 chr18:46477404 SMAD7 0.4 6.06 0.32 3.82e-9 Liver disease severity in Alagille syndrome; CRC cis rs6121246 0.738 rs6121242 chr20:30410877 T/C cg13852791 chr20:30311386 BCL2L1 0.68 10.87 0.51 1.03e-23 Mean corpuscular hemoglobin; CRC cis rs10789491 0.951 rs35050319 chr1:47103886 C/A cg15501359 chr1:47185051 KIAA0494 -0.7 -7.87 -0.4 5.18e-14 Response to hepatitis C treatment; CRC cis rs6694672 1.000 rs1332669 chr1:197005883 C/T cg13682187 chr1:196946512 CFHR5 0.43 6.89 0.36 2.85e-11 Asthma; CRC cis rs9399137 0.507 rs4451150 chr6:135279063 T/G cg22676075 chr6:135203613 NA 0.61 8.97 0.44 2.29e-17 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; CRC cis rs9925964 0.869 rs749670 chr16:31088625 A/G cg03418659 chr16:31128414 MYST1 0.47 6.74 0.35 7.01e-11 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs1577917 1.000 rs34106666 chr6:86676258 G/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.51 -6.75 -0.35 6.53e-11 Response to antipsychotic treatment; CRC cis rs4930561 0.714 rs6591335 chr11:67976812 T/C cg04465784 chr11:67976953 SUV420H1 -0.3 -6.01 -0.31 4.86e-9 Breast cancer in childhood cancer survivors;IgG glycosylation; CRC cis rs11212617 0.870 rs227078 chr11:108250381 G/A cg01991180 chr11:108092276 ATM;NPAT 0.44 6.62 0.34 1.5e-10 Response to metformin in type 2 diabetes (glycemic); CRC cis rs6701037 0.748 rs11583687 chr1:175132049 A/C cg00321850 chr1:175162397 KIAA0040 0.42 6.82 0.35 4.42e-11 Alcohol dependence; CRC cis rs6964587 1.000 rs57816416 chr7:91736078 A/C cg17063962 chr7:91808500 NA 0.81 14.06 0.61 1.72e-35 Breast cancer; CRC trans rs10504229 0.953 rs6990806 chr8:58183113 G/A cg04077850 chr5:125800366 GRAMD3 0.37 6.27 0.33 1.15e-9 Developmental language disorder (linguistic errors); CRC trans rs17685 0.633 rs3801471 chr7:75696188 T/G cg19862616 chr7:65841803 NCRNA00174 1.0 18.91 0.72 1.68e-54 Coffee consumption;Coffee consumption (cups per day); CRC cis rs7833790 0.660 rs1451995 chr8:82746123 G/C cg27398817 chr8:82754497 SNX16 0.43 5.86 0.31 1.13e-8 Diastolic blood pressure; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg16587794 chr15:69706675 KIF23 0.45 6.95 0.36 1.92e-11 Intelligence (multi-trait analysis); CRC cis rs4665809 1.000 rs4665809 chr2:26251361 C/T cg25036284 chr2:26402008 FAM59B 0.45 5.75 0.3 2.01e-8 Gut microbiome composition (summer); CRC cis rs651907 0.557 rs11712748 chr3:101383562 G/A cg12386194 chr3:101231763 SENP7 0.46 6.68 0.35 1.01e-10 Colorectal cancer; CRC cis rs9325144 0.510 rs7952795 chr12:38720686 C/T cg13010199 chr12:38710504 ALG10B 0.43 6.26 0.33 1.19e-9 Morning vs. evening chronotype; CRC cis rs2549003 0.870 rs10053046 chr5:131821558 A/G cg02551604 chr5:131831745 NA -0.54 -8.34 -0.42 2e-15 Asthma (sex interaction); CRC cis rs9549328 0.564 rs34556022 chr13:113617437 G/A cg08614441 chr13:113633676 MCF2L 0.4 7.06 0.36 9.78e-12 Systolic blood pressure; CRC cis rs853679 0.517 rs1853097 chr6:28058635 A/G cg06470822 chr6:28175283 NA 1.0 13.31 0.59 1.27e-32 Depression; CRC cis rs13118159 0.550 rs28614045 chr4:1374695 C/A cg16405210 chr4:1374714 KIAA1530 -0.93 -15.48 -0.65 5.67e-41 Longevity; CRC cis rs2836633 0.929 rs4514962 chr21:40041753 C/T cg05519781 chr21:40033154 ERG 0.68 13.27 0.59 1.78e-32 Coronary artery disease; CRC cis rs812925 1.000 rs812925 chr2:61680993 C/G cg10580144 chr2:61372316 C2orf74 -0.31 -6.5 -0.34 2.94e-10 Immature fraction of reticulocytes; CRC cis rs672059 1.000 rs480132 chr1:183161779 A/G ch.1.3577855R chr1:183094577 LAMC1 0.5 7.16 0.37 5.19e-12 Hypertriglyceridemia; CRC cis rs6479527 0.806 rs10761309 chr9:96753722 C/T cg14459158 chr9:96720562 NA -0.39 -7.08 -0.36 8.74e-12 Esophageal adenocarcinoma; CRC cis rs8060686 0.641 rs13816 chr16:68055495 G/C cg08314208 chr16:67682810 RLTPR -0.52 -6.06 -0.32 3.73e-9 HDL cholesterol;Metabolic syndrome; CRC cis rs10504229 1.000 rs73609747 chr8:58189104 G/C cg02290350 chr8:58132656 NA -0.42 -5.96 -0.31 6.62e-9 Developmental language disorder (linguistic errors); CRC cis rs5769765 0.913 rs4824111 chr22:50284305 A/G cg02269571 chr22:50332266 NA 0.61 8.23 0.41 4.42e-15 Schizophrenia; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg03558408 chr5:134181967 C5orf24 -0.39 -6.21 -0.32 1.59e-9 Myopia (pathological); CRC cis rs4132509 0.793 rs6694738 chr1:243715210 C/A cg21452805 chr1:244014465 NA 0.56 6.01 0.31 4.82e-9 RR interval (heart rate); CRC cis rs4713118 0.869 rs7776351 chr6:27726731 A/G cg19041857 chr6:27730383 NA 0.41 5.97 0.31 6.27e-9 Parkinson's disease; CRC cis rs877282 0.945 rs10904555 chr10:787740 C/A cg17470449 chr10:769945 NA 0.69 9.03 0.45 1.51e-17 Uric acid levels; CRC cis rs6499255 1.000 rs73579497 chr16:69824150 C/G cg15192750 chr16:69999425 NA 0.56 7.27 0.37 2.67e-12 IgE levels; CRC cis rs6424115 0.830 rs2501425 chr1:24199339 A/C cg10978503 chr1:24200527 CNR2 0.62 11.34 0.53 2.2e-25 Immature fraction of reticulocytes; CRC cis rs597539 0.652 rs592697 chr11:68650064 G/A cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.9 15.68 0.65 8.67e-42 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs12681288 0.862 rs935821 chr8:1022455 G/A cg15309053 chr8:964076 NA 0.41 7.17 0.37 5.09e-12 Schizophrenia; CRC cis rs7119 0.717 rs12910975 chr15:77817487 C/T cg27398640 chr15:77910606 LINGO1 -0.43 -7.47 -0.38 7.13e-13 Type 2 diabetes; CRC cis rs4481887 0.800 rs4278391 chr1:248450495 C/T cg00666640 chr1:248458726 OR2T12 0.55 9.74 0.47 7.45e-20 Common traits (Other); CRC cis rs2239547 0.603 rs17304995 chr3:53070755 A/G cg11645453 chr3:52864694 ITIH4 0.46 7.08 0.36 8.82e-12 Schizophrenia; CRC cis rs174601 0.861 rs174547 chr11:61570783 C/T cg00603274 chr11:61596626 FADS2 0.45 6.67 0.35 1.08e-10 Blood metabolite levels;Red blood cell fatty acid levels;Liver enzyme levels (alkaline phosphatase);Gondoic acid (20:1n-9) levels;Trans fatty acid levels; CRC cis rs56104184 0.775 rs56146968 chr19:49398847 A/G cg21252483 chr19:49399788 TULP2 -0.43 -6.62 -0.34 1.49e-10 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; CRC cis rs8180040 0.966 rs12632132 chr3:47477019 C/T cg02527881 chr3:46936655 PTH1R -0.4 -7.61 -0.39 2.87e-13 Colorectal cancer; CRC cis rs12477438 0.798 rs4622780 chr2:99631760 C/G cg14399236 chr2:99771627 LIPT1;TSGA10 -0.71 -9.93 -0.48 1.71e-20 Chronic sinus infection; CRC cis rs1580019 0.885 rs3801331 chr7:32497039 A/G cg07520158 chr7:32535189 LSM5;AVL9 -0.47 -6.43 -0.33 4.56e-10 Cognitive ability; CRC cis rs897984 0.721 rs2305884 chr16:30970741 G/A cg00531865 chr16:30841666 NA 0.47 6.77 0.35 5.97e-11 Dementia with Lewy bodies; CRC cis rs9733 0.596 rs7549795 chr1:150656873 G/A cg15448220 chr1:150897856 SETDB1 0.45 6.42 0.33 4.85e-10 Tonsillectomy; CRC cis rs9443645 0.901 rs9352683 chr6:79718795 T/G cg05283184 chr6:79620031 NA -0.61 -9.64 -0.47 1.54e-19 Intelligence (multi-trait analysis); CRC cis rs4713118 0.629 rs172165 chr6:28020814 T/G cg21251018 chr6:28226885 NKAPL 0.45 6.51 0.34 2.73e-10 Parkinson's disease; CRC cis rs7044106 0.708 rs10760113 chr9:123474050 T/C cg09586646 chr9:123605570 PSMD5;LOC253039 0.63 9.15 0.45 6.27e-18 Hip circumference adjusted for BMI; CRC cis rs939658 1.000 rs4778935 chr15:79453282 T/C cg17916960 chr15:79447300 NA 0.46 7.5 0.38 5.95e-13 Refractive error; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg00553120 chr7:157129669 DNAJB6 0.46 6.45 0.34 4.1e-10 Anxiety disorder; CRC cis rs2439831 0.850 rs12101756 chr15:44053887 A/G cg02155558 chr15:43621948 ADAL;LCMT2 0.69 7.61 0.39 2.95e-13 Lung cancer in ever smokers; CRC cis rs2243480 0.708 rs781141 chr7:65438553 A/G cg18252515 chr7:66147081 NA -1.06 -12.42 -0.56 2.67e-29 Diabetic kidney disease; CRC cis rs7666738 0.830 rs1115616 chr4:99006603 A/C cg17366294 chr4:99064904 C4orf37 0.43 7.32 0.37 1.94e-12 Colonoscopy-negative controls vs population controls; CRC cis rs35146811 0.520 rs1015538 chr7:99626035 A/G cg13334819 chr7:99746414 C7orf59 0.52 7.6 0.39 3.03e-13 Coronary artery disease; CRC cis rs17401966 0.838 rs35759975 chr1:10474430 A/T cg19773385 chr1:10388646 KIF1B -0.65 -10.44 -0.5 3.23e-22 Hepatocellular carcinoma; CRC cis rs7727544 0.507 rs9791170 chr5:131569627 A/G cg01305625 chr5:131593812 PDLIM4 0.32 5.74 0.3 2.15e-8 Blood metabolite levels; CRC cis rs2933343 1.000 rs1683778 chr3:128644595 A/G cg11901034 chr3:128598214 ACAD9 -0.52 -6.3 -0.33 9.3e-10 IgG glycosylation; CRC cis rs867529 0.600 rs335120 chr2:89072731 A/G cg26627705 chr2:89060884 NA 0.57 7.51 0.38 5.61e-13 Height; CRC cis rs6461049 0.765 rs3800908 chr7:2159437 C/T cg02951883 chr7:2050386 MAD1L1 -0.56 -9.14 -0.45 6.47e-18 Schizophrenia; CRC cis rs17125944 0.686 rs7160582 chr14:53341445 G/T cg00686598 chr14:53173677 PSMC6 0.8 7.05 0.36 1.03e-11 Alzheimer's disease (late onset); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg27431859 chr19:531042 CDC34 0.56 8.07 0.41 1.29e-14 Response to antipsychotic treatment; CRC cis rs8062405 0.755 rs17640009 chr16:28595700 A/G cg05139728 chr16:28306816 SBK1 -0.38 -6.23 -0.32 1.4e-9 Cognitive ability (multi-trait analysis);Cognitive ability; CRC cis rs1832871 0.711 rs6906854 chr6:158695000 C/T cg07165851 chr6:158734300 TULP4 0.6 7.58 0.39 3.46e-13 Height; CRC cis rs1008375 0.932 rs9283698 chr4:17662471 T/C cg16339924 chr4:17578868 LAP3 0.49 6.13 0.32 2.56e-9 Parasitemia in Tripanosoma cruzi seropositivity; CRC trans rs1455244 0.700 rs7229302 chr18:11508904 G/T cg06893537 chr18:47901419 SKA1 0.42 6.39 0.33 5.57e-10 Schizophrenia; CRC cis rs9467711 0.720 rs35627490 chr6:26462104 C/T cg16898833 chr6:26189333 HIST1H4D 1.12 8.21 0.41 5.22e-15 Autism spectrum disorder or schizophrenia; CRC cis rs733175 0.855 rs10016075 chr4:10006663 G/T cg00071950 chr4:10020882 SLC2A9 0.39 5.66 0.3 3.22e-8 Psychosis and Alzheimer's disease; CRC cis rs12980942 0.872 rs7248164 chr19:41807700 G/A cg25627403 chr19:41769009 HNRNPUL1 0.44 5.66 0.3 3.24e-8 Coronary artery disease; CRC cis rs7224737 1.000 rs7219220 chr17:40294280 T/C cg00647820 chr17:40259828 DHX58 -0.46 -6.48 -0.34 3.44e-10 Fibrinogen levels; CRC trans rs2228479 0.717 rs17226274 chr16:89850170 C/T cg24644049 chr4:85504048 CDS1 0.85 7.25 0.37 3.09e-12 Skin colour saturation; CRC cis rs2408955 0.521 rs11168437 chr12:48566156 C/T cg00601486 chr12:48723148 H1FNT 0.35 6.45 0.34 3.93e-10 Glycated hemoglobin levels; CRC cis rs9463078 0.683 rs227847 chr6:44695493 A/G cg25276700 chr6:44698697 NA 0.25 5.95 0.31 6.84e-9 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; CRC cis rs6499255 0.951 rs56282083 chr16:69825728 C/T cg04110750 chr16:69646130 NFAT5 -0.52 -6.92 -0.36 2.3e-11 IgE levels; CRC cis rs9858542 1.000 rs9836291 chr3:49697459 G/A cg03060546 chr3:49711283 APEH -0.54 -7.45 -0.38 8.56e-13 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs6088590 0.965 rs6087619 chr20:33288511 C/G cg24642439 chr20:33292090 TP53INP2 0.61 10.82 0.51 1.55e-23 Coronary artery disease; CRC cis rs58688157 0.705 rs12795572 chr11:590999 G/A cg03909863 chr11:638404 DRD4 -0.53 -7.03 -0.36 1.17e-11 Systemic lupus erythematosus; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg23053741 chr5:72112459 TNPO1 0.37 6.16 0.32 2.09e-9 Liver disease severity in Alagille syndrome; CRC cis rs11764590 0.694 rs4721359 chr7:2104951 A/G cg23422044 chr7:1970798 MAD1L1 -0.42 -5.77 -0.3 1.82e-8 Neuroticism; CRC cis rs3818285 0.504 rs7100154 chr10:111650150 T/C cg00817464 chr10:111662876 XPNPEP1 -0.44 -5.95 -0.31 6.77e-9 Superior crus of antihelix expression; CRC cis rs2033711 0.755 rs4801587 chr19:58936679 C/A cg13877915 chr19:58951672 ZNF132 0.52 8.56 0.43 4.37e-16 Uric acid clearance; CRC cis rs11628318 0.614 rs10132160 chr14:103058023 A/G cg12046867 chr14:103022105 NA -0.78 -9.31 -0.46 1.88e-18 Platelet count; CRC cis rs9635542 0.920 rs759194 chr16:5006249 C/G cg06510647 chr16:5006106 NA -0.63 -6.87 -0.35 3.14e-11 Lung cancer (asbestos exposure interaction);Cancer; CRC cis rs35306767 0.623 rs36062650 chr10:1142571 T/C cg26597838 chr10:835615 NA 0.51 6.85 0.35 3.6e-11 Eosinophil percentage of granulocytes; CRC cis rs4638749 0.501 rs6733637 chr2:108804564 A/G cg25838818 chr2:108905173 SULT1C2 -0.31 -5.78 -0.3 1.7e-8 Blood pressure; CRC cis rs6502050 0.799 rs6502078 chr17:80124364 G/A cg02741985 chr17:80059408 CCDC57 0.43 7.15 0.37 5.59e-12 Life satisfaction; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg17706896 chr19:46406599 MYPOP 0.39 6.04 0.32 4.28e-9 Intelligence (multi-trait analysis); CRC cis rs9322193 0.886 rs9767555 chr6:149968158 T/C cg00933542 chr6:150070202 PCMT1 0.32 6.3 0.33 9.48e-10 Lung cancer; CRC cis rs995000 0.895 rs597076 chr1:62917865 T/A cg19896129 chr1:63156450 NA 0.44 6.78 0.35 5.59e-11 Triglyceride levels; CRC cis rs12134245 0.874 rs35115044 chr1:92021650 A/G cg21854759 chr1:92012499 NA -0.39 -6.03 -0.32 4.45e-9 Breast cancer; CRC cis rs8180040 0.764 rs11708451 chr3:47198826 G/A cg10298567 chr3:47292165 KIF9 -0.36 -5.77 -0.3 1.8e-8 Colorectal cancer; CRC trans rs1899951 1.000 rs2881654 chr3:12396955 G/A cg04083076 chr1:169452126 SLC19A2 -0.48 -6.13 -0.32 2.58e-9 Body mass index; CRC cis rs9311676 0.632 rs62258075 chr3:58359851 G/A cg06643156 chr3:58380774 PXK 0.43 6.73 0.35 7.6e-11 Systemic lupus erythematosus; CRC cis rs929354 0.742 rs6459734 chr7:156935454 A/G cg05182265 chr7:156933206 UBE3C -0.76 -14.38 -0.62 1.04e-36 Body mass index; CRC cis rs4713118 0.513 rs149950 chr6:28033039 T/G cg12172441 chr6:28176163 NA 0.51 7.07 0.36 9.54e-12 Parkinson's disease; CRC cis rs146201400 1 rs146201400 chr1:26645955 G/GA cg00852783 chr1:26633632 UBXN11 0.49 6.84 0.35 3.81e-11 Monocyte percentage of white cells; CRC trans rs10982213 0.830 rs2274163 chr9:117188714 C/T cg23235142 chr7:45066841 CCM2 0.3 6.68 0.35 9.98e-11 Interleukin-6 levels; CRC cis rs2230307 0.536 rs561119 chr1:100603891 G/A cg24955406 chr1:100503596 HIAT1 -0.49 -5.94 -0.31 7.28e-9 Carotid intima media thickness; CRC cis rs2797160 0.684 rs1832937 chr6:125985934 A/G cg05901451 chr6:126070800 HEY2 0.41 6.32 0.33 8.44e-10 Endometrial cancer; CRC cis rs8060686 0.925 rs13336189 chr16:67814152 C/A cg00318322 chr16:67708822 GFOD2 -0.32 -5.81 -0.31 1.47e-8 HDL cholesterol;Metabolic syndrome; CRC cis rs3771570 0.892 rs55751610 chr2:242346057 C/T cg21155796 chr2:242212141 HDLBP 0.65 6.99 0.36 1.58e-11 Prostate cancer; CRC cis rs1568889 1.000 rs12800354 chr11:28047723 T/C cg06544937 chr11:28130018 METT5D1;KIF18A 0.76 9.78 0.47 5.38e-20 Bipolar disorder; CRC cis rs703980 0.565 rs703969 chr10:80953393 C/G cg20744163 chr10:80999841 ZMIZ1 -0.32 -5.74 -0.3 2.11e-8 Type 2 diabetes; CRC cis rs1375194 0.509 rs62150473 chr2:33822320 G/A cg04131969 chr2:33951647 MYADML -0.55 -8.07 -0.41 1.32e-14 Response to antidepressants in depression; CRC cis rs12477438 0.735 rs12474477 chr2:99690408 G/T cg26064155 chr2:99771622 LIPT1;TSGA10 -0.79 -11.22 -0.53 6.09e-25 Chronic sinus infection; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg12034229 chr7:48018855 HUS1 0.41 6.07 0.32 3.52e-9 Response to antipsychotic treatment; CRC cis rs4604732 0.631 rs10925043 chr1:247627001 G/A cg12758973 chr1:247694275 LOC148824;OR2C3 0.42 6.14 0.32 2.32e-9 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CRC cis rs9287719 0.967 rs6706542 chr2:10742491 A/C cg00105475 chr2:10696890 NA 0.45 7.3 0.37 2.19e-12 Prostate cancer; CRC cis rs2976388 1.000 rs2572910 chr8:143770135 C/G cg24046110 chr8:143859143 LYNX1 -0.4 -6.92 -0.36 2.39e-11 Urinary tract infection frequency; CRC cis rs6952808 0.636 rs6964522 chr7:1953523 C/T cg21782813 chr7:2030301 MAD1L1 0.39 7.18 0.37 4.67e-12 Bipolar disorder and schizophrenia; CRC cis rs11098499 0.909 rs11723839 chr4:120299673 G/A cg24375607 chr4:120327624 NA 0.5 7.76 0.39 1.06e-13 Corneal astigmatism; CRC cis rs990171 0.913 rs6543132 chr2:103029410 A/G cg03938978 chr2:103052716 IL18RAP 0.46 5.82 0.31 1.4e-8 Lymphocyte counts; CRC cis rs7945705 0.747 rs1980429 chr11:9010474 C/A cg21881798 chr11:8931708 C11orf17;ST5 -0.66 -11.01 -0.52 3.26e-24 Hemoglobin concentration; CRC cis rs12594515 0.967 rs8039088 chr15:45990178 T/C cg22117107 chr15:45993392 NA -0.44 -9.09 -0.45 9.56e-18 Waist circumference;Weight; CRC cis rs832540 0.656 rs702689 chr5:56177443 G/A cg12311346 chr5:56204834 C5orf35 -0.49 -6.96 -0.36 1.86e-11 Coronary artery disease; CRC cis rs992157 0.732 rs10932771 chr2:219170236 A/T cg00012203 chr2:219082015 ARPC2 0.43 6.68 0.35 1.04e-10 Colorectal cancer; CRC cis rs1044826 0.642 rs295478 chr3:139223135 G/A cg00490450 chr3:139108681 COPB2 0.43 6.43 0.33 4.53e-10 Obesity-related traits; CRC cis rs9905704 0.647 rs9901655 chr17:56987142 G/A cg12560992 chr17:57184187 TRIM37 0.62 9.41 0.46 8.91e-19 Testicular germ cell tumor; CRC cis rs2274273 0.564 rs3783649 chr14:55834410 G/A cg10130446 chr14:55658398 DLGAP5 -0.41 -5.76 -0.3 1.92e-8 Protein biomarker; CRC trans rs1814175 0.529 rs10839396 chr11:49852406 G/T cg03929089 chr4:120376271 NA 0.8 11.23 0.53 5.39e-25 Height; CRC cis rs11625487 0.609 rs74063206 chr14:77981045 C/T cg20045696 chr14:77926864 AHSA1 -0.65 -5.88 -0.31 1.03e-8 Neutrophil percentage of white cells;Sum neutrophil eosinophil counts;Neutrophil count; CRC cis rs2228479 0.867 rs11642451 chr16:89958127 T/C cg06656553 chr16:89960601 TCF25 -0.64 -5.82 -0.31 1.39e-8 Skin colour saturation; CRC cis rs2797160 1.000 rs9321050 chr6:126001568 A/G cg05901451 chr6:126070800 HEY2 -0.41 -6.2 -0.32 1.67e-9 Endometrial cancer; CRC cis rs9814567 0.896 rs6790338 chr3:134208167 G/C cg06541857 chr3:134203789 ANAPC13;CEP63 -0.4 -5.97 -0.31 6.26e-9 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs4363385 0.818 rs4845335 chr1:152993955 G/A cg25856811 chr1:152973957 SPRR3 -0.26 -7.22 -0.37 3.65e-12 Inflammatory skin disease; CRC cis rs11112613 0.648 rs11112635 chr12:106047112 A/G cg03607813 chr12:105948248 NA 0.47 5.73 0.3 2.27e-8 Corrected insulin response;Corrected insulin response adjusted for insulin sensitivity index; CRC cis rs6429082 0.511 rs12748957 chr1:235426133 T/A cg26050004 chr1:235667680 B3GALNT2 0.38 5.64 0.3 3.68e-8 Adiposity; CRC cis rs2290405 0.527 rs4690332 chr4:910520 C/T cg10113582 chr4:905918 GAK 0.45 6.93 0.36 2.17e-11 Systemic sclerosis; CRC cis rs9303401 0.538 rs12603174 chr17:56489279 T/C cg02118635 chr17:56770003 RAD51C;TEX14 0.7 8.6 0.43 3.27e-16 Cognitive test performance; CRC cis rs78663649 0.540 rs7252709 chr19:16721183 T/G cg10248733 chr19:16607483 C19orf44;CALR3 -0.82 -6.13 -0.32 2.56e-9 White blood cell count; CRC cis rs1577917 0.958 rs36035797 chr6:86562880 G/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.51 -6.59 -0.34 1.76e-10 Response to antipsychotic treatment; CRC cis rs4665809 1.000 rs11126364 chr2:26314515 A/G cg22920501 chr2:26401640 FAM59B -0.53 -7.23 -0.37 3.4e-12 Gut microbiome composition (summer); CRC cis rs6912958 0.514 rs1980792 chr6:87889917 A/G cg12350822 chr6:88032061 C6orf162;GJB7 -0.47 -9.62 -0.47 1.8e-19 Monocyte percentage of white cells; CRC cis rs6088580 0.524 rs11167241 chr20:33250835 C/T cg08999081 chr20:33150536 PIGU -0.37 -5.61 -0.3 4.4e-8 Glomerular filtration rate (creatinine); CRC trans rs7944735 0.671 rs1228044 chr11:48011180 A/G cg15704280 chr7:45808275 SEPT13 0.55 7.34 0.38 1.7e-12 Intraocular pressure; CRC cis rs4319547 0.741 rs4758663 chr12:122939483 A/G cg05707623 chr12:122985044 ZCCHC8 -0.56 -7.24 -0.37 3.21e-12 Body mass index; CRC cis rs4660261 0.562 rs3011223 chr1:44318286 T/C cg12908607 chr1:44402522 ARTN -0.52 -9.44 -0.46 7.16e-19 Intelligence (multi-trait analysis); CRC cis rs1008375 1.000 rs114490726 chr4:17680898 T/C cg16339924 chr4:17578868 LAP3 0.5 6.47 0.34 3.62e-10 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs2179367 0.919 rs4897124 chr6:149763209 T/C cg11245181 chr6:149772854 ZC3H12D -0.43 -6.88 -0.35 3e-11 Dupuytren's disease; CRC cis rs17665859 0.669 rs56187424 chr8:447194 A/G cg15469184 chr8:337539 NA -0.5 -5.77 -0.3 1.79e-8 Bilirubin levels; CRC cis rs853679 0.599 rs149943 chr6:28002388 G/A cg03623178 chr6:28175578 NA 0.84 7.95 0.4 2.95e-14 Depression; CRC cis rs7043114 0.525 rs10820969 chr9:95106678 G/C cg14631576 chr9:95140430 CENPP -0.31 -5.9 -0.31 9.24e-9 Height; CRC cis rs2204008 0.592 rs2320501 chr12:38145285 T/G cg26384229 chr12:38710491 ALG10B 0.66 8.85 0.44 5.65e-17 Bladder cancer; CRC cis rs6496667 0.908 rs8040697 chr15:90853427 A/C cg04176472 chr15:90893244 GABARAPL3 0.51 7.2 0.37 4.11e-12 Rheumatoid arthritis; CRC cis rs427394 0.659 rs274678 chr5:6752385 A/G cg15145174 chr5:6755386 POLS 0.45 6.56 0.34 2.09e-10 Menopause (age at onset); CRC cis rs7954584 0.531 rs10840631 chr12:122373729 C/T cg21171335 chr12:122356390 WDR66 0.4 6.13 0.32 2.5e-9 Mean corpuscular volume; CRC trans rs877282 0.898 rs34490091 chr10:765800 A/C cg22713356 chr15:30763199 NA 1.3 15.02 0.64 3.32e-39 Uric acid levels; CRC cis rs1559088 0.948 rs10406916 chr19:33590093 G/A cg27124370 chr19:33622961 WDR88 0.45 6.31 0.33 9.08e-10 Bone ultrasound measurement (broadband ultrasound attenuation); CRC cis rs4423214 0.879 rs4945008 chr11:71221248 A/G cg05163923 chr11:71159392 DHCR7 0.63 8.79 0.44 8.76e-17 Vitamin D levels; CRC cis rs10779751 0.690 rs28729193 chr1:11180151 T/C cg08854313 chr1:11322531 MTOR -0.59 -7.63 -0.39 2.48e-13 Body mass index; CRC trans rs10411161 1.000 rs8106929 chr19:52368467 A/G cg22319618 chr22:45562946 NUP50 -0.51 -6.04 -0.32 4.26e-9 Breast cancer; CRC cis rs7572644 0.640 rs13027666 chr2:28058433 T/C cg27432699 chr2:27873401 GPN1 0.46 6.23 0.32 1.43e-9 Response to carboplatin and paclitaxel in ovarian cancer (Caspase 3/7 EC50); CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg20467896 chr19:6361623 CLPP 0.44 6.12 0.32 2.67e-9 Anxiety disorder; CRC trans rs2228479 0.850 rs2283565 chr16:89827556 G/T cg24644049 chr4:85504048 CDS1 0.86 6.93 0.36 2.29e-11 Skin colour saturation; CRC cis rs7772486 0.720 rs4896837 chr6:146014168 C/T cg05347473 chr6:146136440 FBXO30 -0.4 -6.02 -0.32 4.65e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs270601 0.770 rs932019 chr5:131599370 T/C cg20512303 chr5:131592959 PDLIM4 0.4 7.6 0.39 3.07e-13 Acylcarnitine levels; CRC cis rs11098499 0.863 rs7695620 chr4:120452776 G/A cg24375607 chr4:120327624 NA 0.47 7.05 0.36 1.06e-11 Corneal astigmatism; CRC cis rs7666738 0.830 rs10470893 chr4:99038756 C/T cg17366294 chr4:99064904 C4orf37 0.44 7.5 0.38 6.02e-13 Colonoscopy-negative controls vs population controls; CRC cis rs7671266 0.611 rs10939833 chr4:10309537 A/G cg11266682 chr4:10021025 SLC2A9 -0.37 -5.88 -0.31 1.03e-8 Cardiovascular disease risk factors; CRC cis rs56104184 0.723 rs1058483 chr19:49407660 G/A cg15549821 chr19:49342101 PLEKHA4 -0.53 -5.98 -0.31 5.86e-9 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; CRC cis rs72781680 1.000 rs6751655 chr2:24155478 A/G cg08917208 chr2:24149416 ATAD2B 1.03 10.24 0.49 1.55e-21 Lymphocyte counts; CRC cis rs801193 1.000 rs1553609 chr7:66197139 T/C cg00343986 chr7:65444356 GUSB 0.49 7.26 0.37 2.9e-12 Aortic root size; CRC cis rs896854 0.654 rs4735337 chr8:95973465 T/C cg09323728 chr8:95962352 TP53INP1 -0.45 -7.47 -0.38 7.43e-13 Type 2 diabetes; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg24093429 chr19:12722027 ZNF791;ZNF490 0.42 6.86 0.35 3.47e-11 Liver disease severity in Alagille syndrome; CRC cis rs9611519 1.000 rs2273085 chr22:41615376 C/T cg03806693 chr22:41940476 POLR3H -0.49 -6.38 -0.33 6.12e-10 Neuroticism; CRC cis rs780096 0.525 rs13388159 chr2:27648284 A/T cg17158414 chr2:27665306 KRTCAP3 -0.29 -6.28 -0.33 1.06e-9 Total body bone mineral density; CRC trans rs1455244 0.700 rs7229302 chr18:11508904 G/T cg10079107 chr15:31507907 NA 0.39 5.99 0.31 5.41e-9 Schizophrenia; CRC trans rs45509595 0.841 rs200501 chr6:27788942 C/T cg16898833 chr6:26189333 HIST1H4D 0.72 6.46 0.34 3.84e-10 Breast cancer; CRC cis rs13108904 0.557 rs1250086 chr4:1248051 G/A cg16405210 chr4:1374714 KIAA1530 0.74 10.58 0.5 1.04e-22 Obesity-related traits; CRC cis rs7618915 0.571 rs6762457 chr3:52609157 G/A cg18099408 chr3:52552593 STAB1 -0.44 -7.36 -0.38 1.52e-12 Bipolar disorder; CRC cis rs524281 0.861 rs10750778 chr11:65948648 T/C cg16950941 chr11:66035639 RAB1B -0.6 -7.43 -0.38 9.29e-13 Electroencephalogram traits; CRC cis rs3018066 0.692 rs7698386 chr4:107038946 T/C cg01869342 chr4:106983673 TBCK 0.44 5.82 0.31 1.36e-8 Cancer; CRC cis rs7591163 1.000 rs4973380 chr2:228725402 T/A cg23807890 chr2:228736357 WDR69 -0.48 -6.62 -0.34 1.43e-10 Blood pressure; CRC cis rs1129187 0.686 rs6458313 chr6:42922018 A/G cg27588902 chr6:42928151 GNMT -0.42 -7.41 -0.38 1.05e-12 Alzheimer's disease in APOE e4+ carriers; CRC cis rs1707322 1.000 rs7526369 chr1:46390560 G/C cg03146154 chr1:46216737 IPP 0.5 7.04 0.36 1.12e-11 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs4731207 0.503 rs1481325 chr7:124625753 C/T cg23710748 chr7:124431027 NA -0.39 -6.25 -0.33 1.29e-9 Cutaneous malignant melanoma; CRC cis rs60871478 1.000 rs62432252 chr7:802886 C/G cg13844804 chr7:814759 HEATR2 0.67 8.61 0.43 3.1e-16 Cerebrospinal P-tau181p levels; CRC trans rs7937682 0.883 rs566647 chr11:111466607 A/G cg18187862 chr3:45730750 SACM1L -0.44 -6.23 -0.32 1.45e-9 Primary sclerosing cholangitis; CRC trans rs853679 1.000 rs9986596 chr6:28219661 G/A cg06606381 chr12:133084897 FBRSL1 -0.69 -6.68 -0.35 1.02e-10 Depression; CRC cis rs72945132 0.882 rs67283107 chr11:70221204 C/T cg00319359 chr11:70116639 PPFIA1 0.55 6.04 0.32 4.17e-9 Coronary artery disease; CRC cis rs55788414 0.932 rs2873367 chr16:81184380 T/A cg06400318 chr16:81190750 PKD1L2 -0.59 -6.76 -0.35 6.2e-11 Left ventricular obstructive tract defect (maternal effect); CRC cis rs16852403 0.517 rs316266 chr1:178102481 G/C cg00404053 chr1:178313656 RASAL2 -0.49 -6.58 -0.34 1.87e-10 Childhood ear infection; CRC cis rs6963495 0.818 rs73190166 chr7:105159955 G/A cg13798780 chr7:105162888 PUS7 0.68 8.08 0.41 1.27e-14 Bipolar disorder (body mass index interaction); CRC cis rs875971 0.862 rs10256544 chr7:65675128 A/G cg18876405 chr7:65276391 NA 0.53 8.85 0.44 5.56e-17 Aortic root size; CRC cis rs6502050 0.835 rs9902485 chr17:80093701 C/T cg09264619 chr17:80180166 NA -0.35 -5.86 -0.31 1.1e-8 Life satisfaction; CRC cis rs66887589 0.934 rs7672519 chr4:120544112 C/T cg09307838 chr4:120376055 NA -0.51 -7.79 -0.39 8.79e-14 Diastolic blood pressure; CRC cis rs6662572 0.737 rs10749859 chr1:46314170 C/T cg08644498 chr1:46502608 NA 0.46 7.35 0.38 1.59e-12 Blood protein levels; CRC cis rs4243830 0.579 rs10779794 chr1:6612651 C/G cg22792644 chr1:6614718 TAS1R1;NOL9 -0.81 -9.88 -0.48 2.55e-20 Body mass index; CRC cis rs9309473 1.000 rs7604682 chr2:73788026 G/A cg20560298 chr2:73613845 ALMS1 -0.46 -5.68 -0.3 2.91e-8 Metabolite levels; CRC cis rs1552244 0.935 rs7618815 chr3:10151045 A/G cg10729496 chr3:10149963 C3orf24 0.55 7.1 0.36 7.93e-12 Alzheimer's disease; CRC cis rs80130819 0.688 rs2054902 chr12:48724778 A/C cg21466736 chr12:48725269 NA -0.45 -5.65 -0.3 3.39e-8 Prostate cancer; CRC cis rs7692995 1.000 rs6824748 chr4:17997066 G/A cg08925142 chr4:18023851 LCORL -0.54 -6.03 -0.32 4.31e-9 Height; CRC cis rs910316 0.967 rs11624893 chr14:75660124 A/G cg11812906 chr14:75593930 NEK9 -0.5 -7.46 -0.38 7.81e-13 Height; CRC cis rs4654899 1.000 rs6681064 chr1:21339644 A/G cg02927042 chr1:21476669 EIF4G3 -0.45 -7.39 -0.38 1.26e-12 Superior frontal gyrus grey matter volume; CRC cis rs12410462 1.000 rs12410462 chr1:227667790 A/G cg04117972 chr1:227635322 NA -0.62 -7.0 -0.36 1.47e-11 Major depressive disorder; CRC cis rs2857891 1.000 rs2857891 chr11:6962957 C/T cg12728517 chr11:6947552 ZNF215 0.56 6.1 0.32 3.03e-9 Response to cytadine analogues (cytosine arabinoside); CRC trans rs208520 0.690 rs207107 chr6:66794385 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.08 -15.36 -0.65 1.56e-40 Exhaled nitric oxide output; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg05520353 chr13:113597554 NA 0.4 6.01 0.31 4.93e-9 Intelligence (multi-trait analysis); CRC cis rs10911363 0.592 rs2761581 chr1:183474850 G/C cg09173681 chr1:183549694 NCF2 0.74 10.2 0.49 2.11e-21 Systemic lupus erythematosus; CRC cis rs13256369 1.000 rs873064 chr8:8572380 G/A cg17143192 chr8:8559678 CLDN23 0.46 5.94 0.31 7.35e-9 Obesity-related traits; CRC trans rs13046373 0.905 rs4816372 chr21:32077414 A/T cg20237960 chr7:45926556 IGFBP1 -0.4 -6.3 -0.33 9.67e-10 HDL cholesterol; CRC cis rs477692 0.569 rs871028 chr10:131293478 C/T cg05714579 chr10:131428358 MGMT -0.54 -7.66 -0.39 2.1e-13 Response to temozolomide; CRC cis rs1887596 0.672 rs1831466 chr13:27231212 C/G cg01312412 chr13:27282625 NA 0.43 5.64 0.3 3.76e-8 Facial morphology (factor 3, length of philtrum); CRC cis rs7666738 0.830 rs34870112 chr4:99045815 T/G cg17366294 chr4:99064904 C4orf37 0.45 7.75 0.39 1.16e-13 Colonoscopy-negative controls vs population controls; CRC cis rs7647973 1.000 rs62259933 chr3:49469703 G/A cg20833759 chr3:49053208 WDR6;DALRD3 -0.55 -7.99 -0.4 2.33e-14 Menarche (age at onset); CRC cis rs6921919 0.583 rs35560946 chr6:28395437 C/T cg21251018 chr6:28226885 NKAPL 0.4 6.12 0.32 2.7e-9 Autism spectrum disorder or schizophrenia; CRC cis rs1129187 0.719 rs3805953 chr6:42936900 C/T cg02353165 chr6:42928485 GNMT 0.71 11.6 0.54 2.68e-26 Alzheimer's disease in APOE e4+ carriers; CRC cis rs12325245 0.536 rs35908812 chr16:58587426 T/C cg02549819 chr16:58548995 SETD6 1.16 7.58 0.39 3.52e-13 Schizophrenia; CRC cis rs1046896 0.553 rs8073413 chr17:80836005 G/A cg02711726 chr17:80685570 FN3KRP -0.53 -7.13 -0.37 6.57e-12 Glycated hemoglobin levels; CRC cis rs9858542 0.953 rs7623659 chr3:49414791 C/T cg00383909 chr3:49044727 WDR6 0.43 5.65 0.3 3.45e-8 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs79387448 0.745 rs2310294 chr2:103165706 A/G cg09003973 chr2:102972529 NA 0.73 8.0 0.4 2.09e-14 Gut microbiota (bacterial taxa); CRC cis rs6951245 0.638 rs4720486 chr7:1146764 G/A cg07217954 chr7:1067459 C7orf50 0.48 5.67 0.3 3.15e-8 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs56399783 0.901 rs73047393 chr7:2775879 C/T cg19731401 chr7:2775893 GNA12 0.66 7.15 0.37 5.59e-12 Childhood ear infection; CRC cis rs6570726 0.846 rs4896824 chr6:145927048 C/T cg23711669 chr6:146136114 FBXO30 0.69 11.45 0.53 8.93e-26 Lobe attachment (rater-scored or self-reported); CRC trans rs10983614 1.000 rs7867776 chr9:120072627 A/G cg26917132 chr16:87425759 FBXO31;MAP1LC3B 0.48 6.58 0.34 1.82e-10 Survival in pancreatic cancer; CRC cis rs3749237 0.595 rs4855861 chr3:49525962 G/T cg02487422 chr3:49467188 NICN1 0.43 6.91 0.36 2.5e-11 Resting heart rate; CRC cis rs6968419 0.747 rs58595078 chr7:115881458 A/G cg02561103 chr7:115862891 TES -0.42 -6.35 -0.33 7.09e-10 Intraocular pressure; CRC trans rs6601327 0.641 rs11782886 chr8:9587891 A/G cg06636001 chr8:8085503 FLJ10661 -0.49 -7.17 -0.37 4.91e-12 Multiple myeloma (hyperdiploidy); CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg02667081 chr16:71880439 ATXN1L 0.48 6.28 0.33 1.08e-9 Thyroid stimulating hormone; CRC cis rs66569888 0.583 rs66529457 chr2:106727010 G/A cg16099169 chr2:106886729 NA -0.37 -5.66 -0.3 3.35e-8 Facial morphology (factor 23); CRC cis rs34779708 0.966 rs35777088 chr10:35409048 T/C cg03585969 chr10:35415529 CREM 0.66 8.73 0.43 1.33e-16 Inflammatory bowel disease;Crohn's disease; CRC cis rs4862750 0.872 rs7679956 chr4:187900229 C/T cg03647317 chr4:187891568 NA -0.56 -10.56 -0.5 1.21e-22 Lobe attachment (rater-scored or self-reported); CRC cis rs826838 0.616 rs10880751 chr12:38627485 C/T cg26384229 chr12:38710491 ALG10B 0.54 7.85 0.4 6.03e-14 Heart rate; CRC cis rs7618915 0.547 rs7642198 chr3:52677960 T/C cg10802521 chr3:52805072 NEK4 -0.58 -9.0 -0.44 1.8e-17 Bipolar disorder; CRC cis rs6951245 0.744 rs1133122 chr7:1192572 C/A cg22907277 chr7:1156413 C7orf50 0.76 8.5 0.42 6.61e-16 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs4713118 0.696 rs2394002 chr6:27748015 G/A cg25164649 chr6:28176230 NA 0.59 7.84 0.4 6.16e-14 Parkinson's disease; CRC cis rs1953600 0.870 rs2788295 chr10:81941007 C/G cg04850286 chr10:81895943 PLAC9 0.38 6.74 0.35 7.04e-11 Sarcoidosis; CRC cis rs9926296 0.744 rs164748 chr16:89708292 C/G cg03605463 chr16:89740564 NA 0.58 8.97 0.44 2.34e-17 Vitiligo; CRC cis rs11585357 0.895 rs112208664 chr1:17632010 G/A cg08277548 chr1:17600880 PADI3 -0.84 -11.09 -0.52 1.67e-24 Hair shape; CRC cis rs10788264 0.538 rs1998344 chr10:124030137 A/G cg09507567 chr10:124027408 NA 0.35 7.8 0.4 8.28e-14 Total body bone mineral density; CRC cis rs6089584 0.888 rs6587283 chr20:60613727 A/C cg06108461 chr20:60628389 TAF4 -0.91 -15.56 -0.65 2.7e-41 Body mass index; CRC cis rs4713118 0.784 rs9468219 chr6:27731755 C/A cg02683197 chr6:28174875 NA 0.63 8.19 0.41 5.64e-15 Parkinson's disease; CRC cis rs889398 0.802 rs9940315 chr16:69876164 A/G cg00738113 chr16:70207722 CLEC18C -0.36 -6.21 -0.32 1.6e-9 Body mass index; CRC cis rs35306767 0.623 rs72760943 chr10:1143104 G/A cg26597838 chr10:835615 NA 0.67 7.54 0.38 4.62e-13 Eosinophil percentage of granulocytes; CRC cis rs3825932 0.961 rs11855406 chr15:79234864 C/T cg25744700 chr15:79237217 CTSH -0.39 -6.08 -0.32 3.37e-9 Type 1 diabetes; CRC cis rs853679 0.506 rs1150693 chr6:28174590 T/C cg25164649 chr6:28176230 NA 0.77 10.52 0.5 1.68e-22 Depression; CRC cis rs1150668 0.699 rs1736895 chr6:28219826 G/A cg03623178 chr6:28175578 NA 0.51 7.57 0.39 3.72e-13 Pubertal anthropometrics; CRC cis rs801193 0.569 rs7800620 chr7:66223688 T/C cg18252515 chr7:66147081 NA -0.41 -5.8 -0.3 1.58e-8 Aortic root size; CRC cis rs8014204 1.000 rs4553560 chr14:75334199 T/C cg03030879 chr14:75389066 RPS6KL1 0.55 8.76 0.44 1.03e-16 Caffeine consumption; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg19315081 chr11:10326100 ADM 0.41 5.97 0.31 6.24e-9 Response to antipsychotic treatment; CRC cis rs362272 0.545 rs2239725 chr4:3305739 C/T cg02993699 chr4:3415135 RGS12 -0.38 -6.11 -0.32 2.81e-9 Serum sulfate level; CRC cis rs4731207 0.598 rs2301930 chr7:124465097 A/T cg23710748 chr7:124431027 NA 0.38 6.08 0.32 3.42e-9 Cutaneous malignant melanoma; CRC cis rs782590 0.967 rs62165172 chr2:55736237 A/G cg18811423 chr2:55921094 PNPT1 0.85 15.82 0.66 2.52e-42 Metabolic syndrome; CRC cis rs9287719 0.967 rs10206225 chr2:10758657 A/G cg00105475 chr2:10696890 NA 0.46 7.45 0.38 8.43e-13 Prostate cancer; CRC cis rs9322193 0.923 rs10747276 chr6:150079875 G/A cg00933542 chr6:150070202 PCMT1 0.32 6.68 0.35 9.95e-11 Lung cancer; CRC trans rs5756813 1.000 rs5756813 chr22:38175477 A/C cg19894588 chr14:64061835 NA -0.56 -8.39 -0.42 1.46e-15 Optic cup area;Vertical cup-disc ratio; CRC trans rs8002861 0.905 rs12875052 chr13:44449368 G/C cg17145862 chr1:211918768 LPGAT1 -0.72 -13.13 -0.59 5.74e-32 Leprosy; CRC cis rs1707322 0.686 rs1541131 chr1:46084934 G/A cg03146154 chr1:46216737 IPP -0.66 -9.33 -0.46 1.6e-18 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs16852403 0.619 rs6701497 chr1:178114644 G/C cg00404053 chr1:178313656 RASAL2 0.6 7.56 0.38 4.18e-13 Childhood ear infection; CRC cis rs1953600 0.805 rs2819947 chr10:81947757 T/C cg00277334 chr10:82204260 NA 0.38 6.25 0.33 1.26e-9 Sarcoidosis; CRC cis rs736801 0.740 rs17622378 chr5:131778452 A/G cg07395648 chr5:131743802 NA -0.4 -5.83 -0.31 1.32e-8 Breast cancer;Mosquito bite size; CRC cis rs2882667 0.690 rs700619 chr5:138088749 G/C cg09476006 chr5:138032270 NA -0.57 -9.69 -0.47 1.05e-19 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs10504229 0.906 rs116341227 chr8:58190532 G/C cg02725872 chr8:58115012 NA -0.38 -6.42 -0.33 4.72e-10 Developmental language disorder (linguistic errors); CRC trans rs8073060 0.586 rs8064895 chr17:34001121 T/C cg19694781 chr19:47549865 TMEM160 -1.06 -15.04 -0.64 2.94e-39 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; CRC cis rs863345 0.625 rs10908663 chr1:158492121 C/T cg12129480 chr1:158549410 OR10X1 -0.3 -6.27 -0.33 1.13e-9 Pneumococcal bacteremia; CRC cis rs1577917 0.958 rs66807489 chr6:86440702 T/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.55 -7.34 -0.38 1.66e-12 Response to antipsychotic treatment; CRC cis rs4713118 0.868 rs760587 chr6:27740300 C/A cg25164649 chr6:28176230 NA 0.7 7.93 0.4 3.42e-14 Parkinson's disease; CRC cis rs2842992 0.724 rs9365097 chr6:160211259 G/A cg11366901 chr6:160182831 ACAT2 0.72 10.86 0.51 1.12e-23 Age-related macular degeneration (geographic atrophy); CRC cis rs62064224 0.512 rs9912766 chr17:30712780 A/G cg09324608 chr17:30823087 MYO1D 0.33 5.63 0.3 3.89e-8 Schizophrenia; CRC cis rs2710642 0.861 rs2710644 chr2:63248968 A/C cg17519650 chr2:63277830 OTX1 0.56 7.49 0.38 6.52e-13 LDL cholesterol levels;LDL cholesterol; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg25327839 chr11:73308997 FAM168A -0.4 -6.61 -0.34 1.57e-10 Myopia (pathological); CRC cis rs875971 0.522 rs1701760 chr7:65473688 A/G cg18876405 chr7:65276391 NA 0.66 12.0 0.55 9.24e-28 Aortic root size; CRC cis rs9486719 0.895 rs3798294 chr6:97049587 G/A cg06623918 chr6:96969491 KIAA0776 -0.81 -9.6 -0.47 2.04e-19 Migraine;Coronary artery disease; CRC cis rs9292777 0.897 rs6451493 chr5:40410935 A/C cg09067459 chr5:40385259 NA -0.5 -8.49 -0.42 6.97e-16 Crohn's disease;Multiple sclerosis; CRC cis rs2991971 0.933 rs666720 chr1:46020795 T/C cg15605315 chr1:45957053 TESK2 0.42 6.53 0.34 2.52e-10 High light scatter reticulocyte count; CRC cis rs651907 0.557 rs12629658 chr3:101356535 A/G cg12386194 chr3:101231763 SENP7 0.48 6.89 0.35 2.92e-11 Colorectal cancer; CRC cis rs6700896 0.966 rs4655557 chr1:66080787 T/C cg04111102 chr1:66153794 NA 0.35 6.23 0.32 1.43e-9 C-reactive protein;Mean corpuscular volume;Mean corpuscular hemoglobin; CRC cis rs17065868 0.764 rs7996250 chr13:45029513 A/C cg10246903 chr13:45222710 NA 0.54 5.66 0.3 3.29e-8 Antineutrophil cytoplasmic antibody-associated vasculitis; CRC cis rs4660261 0.526 rs803680 chr1:44364370 G/C cg12908607 chr1:44402522 ARTN -0.53 -9.57 -0.47 2.66e-19 Intelligence (multi-trait analysis); CRC cis rs910187 0.678 rs1046667 chr20:45817255 A/C cg27589058 chr20:45804311 EYA2 -0.4 -7.66 -0.39 2.09e-13 Migraine; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg05038804 chr3:119813689 GSK3B 0.44 6.19 0.32 1.82e-9 Intelligence (multi-trait analysis); CRC cis rs7172677 0.696 rs56262544 chr15:75379471 A/G cg14664628 chr15:75095509 CSK 0.55 6.32 0.33 8.68e-10 Systemic lupus erythematosus and Systemic sclerosis; CRC cis rs8105895 0.867 rs8106762 chr19:22284736 C/T cg02657401 chr19:22469223 NA -0.35 -5.67 -0.3 3.06e-8 Body mass index (change over time); CRC cis rs951366 0.646 rs1772159 chr1:205759195 G/A cg14893161 chr1:205819251 PM20D1 0.98 16.78 0.68 4.33e-46 Menarche (age at onset); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg01423147 chr1:89458345 RBMXL1;CCBL2 0.41 6.5 0.34 3.01e-10 Liver disease severity in Alagille syndrome; CRC cis rs561341 0.609 rs739800 chr17:30190083 T/A cg12193833 chr17:30244370 NA 0.45 6.01 0.31 4.79e-9 Hip circumference adjusted for BMI; CRC cis rs2404602 0.692 rs4360890 chr15:77173295 G/A cg23625390 chr15:77176239 SCAPER 0.46 6.53 0.34 2.56e-10 Blood metabolite levels; CRC cis rs6123683 0.752 rs182784 chr20:55824533 A/G cg13236649 chr20:55835020 BMP7 0.45 7.09 0.36 8.25e-12 Facial morphology (factor 5, width of mouth relative to central midface); CRC cis rs9517313 0.565 rs9556978 chr13:99234648 G/A cg20487152 chr13:99095054 FARP1 -0.48 -6.92 -0.36 2.34e-11 Neuroticism; CRC cis rs2842992 0.747 rs733319 chr6:160221475 A/G cg11366901 chr6:160182831 ACAT2 1.0 14.41 0.62 7.76e-37 Age-related macular degeneration (geographic atrophy); CRC cis rs780096 0.526 rs780106 chr2:27681598 A/C cg22903471 chr2:27725779 GCKR -0.37 -6.06 -0.32 3.65e-9 Total body bone mineral density; CRC cis rs6543140 0.964 rs6543144 chr2:103092575 A/G cg03938978 chr2:103052716 IL18RAP 0.4 6.25 0.33 1.27e-9 Blood protein levels; CRC cis rs4925386 0.840 rs8124907 chr20:60913127 A/G cg06026331 chr20:60912101 LAMA5 0.41 6.18 0.32 1.85e-9 Colorectal cancer;Colorectal cancer (SNP x SNP interaction); CRC cis rs10504229 0.906 rs56130194 chr8:58197061 C/A cg22535103 chr8:58192502 C8orf71 -0.75 -8.71 -0.43 1.46e-16 Developmental language disorder (linguistic errors); CRC cis rs801193 0.613 rs2659900 chr7:66184443 G/C cg18912574 chr7:65842487 NCRNA00174 0.35 5.91 0.31 8.66e-9 Aortic root size; CRC cis rs7172677 0.768 rs72730587 chr15:75358053 A/G cg14664628 chr15:75095509 CSK 0.53 6.46 0.34 3.8e-10 Systemic lupus erythematosus and Systemic sclerosis; CRC cis rs2635047 0.682 rs4534948 chr18:44793419 G/A cg19077165 chr18:44547161 KATNAL2 -0.39 -5.96 -0.31 6.58e-9 Educational attainment; CRC cis rs1023500 0.552 rs133368 chr22:42463689 T/C cg15557168 chr22:42548783 NA -0.37 -6.52 -0.34 2.58e-10 Schizophrenia; CRC cis rs9649213 0.593 rs3823740 chr7:97957104 T/G cg21770322 chr7:97807741 LMTK2 0.52 8.54 0.43 5.11e-16 Prostate cancer (SNP x SNP interaction); CRC cis rs4909189 0.915 rs11773551 chr7:158136146 C/T cg24154853 chr7:158122151 PTPRN2 0.51 7.07 0.36 9.19e-12 Response to amphetamines; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg21877580 chr6:97731105 MIR548H3;C6orf167 0.41 6.0 0.31 5.25e-9 Intelligence (multi-trait analysis); CRC cis rs7954584 0.531 rs10840631 chr12:122373729 C/T cg22618164 chr12:122356400 WDR66 0.37 5.61 0.3 4.23e-8 Mean corpuscular volume; CRC trans rs1814175 0.817 rs7947526 chr11:49983654 T/C cg11707556 chr5:10655725 ANKRD33B -0.42 -7.95 -0.4 2.98e-14 Height; CRC cis rs6951245 0.938 rs11764937 chr7:1092074 C/T cg03188948 chr7:1209495 NA 0.62 6.59 0.34 1.79e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs4819852 0.958 rs9606204 chr22:19976510 C/A cg07821417 chr22:19972146 ARVCF 0.45 6.06 0.32 3.63e-9 Pulse pressure; CRC cis rs4481887 0.927 rs4472779 chr1:248474603 G/A cg00666640 chr1:248458726 OR2T12 0.46 7.9 0.4 4.19e-14 Common traits (Other); CRC cis rs1707322 0.686 rs2991987 chr1:46081422 C/G cg06784218 chr1:46089804 CCDC17 -0.67 -12.26 -0.56 1.03e-28 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs2549003 1.000 rs2070731 chr5:131819798 T/C cg21138405 chr5:131827807 IRF1 0.59 11.66 0.54 1.52e-26 Asthma (sex interaction); CRC cis rs9733 0.650 rs4970923 chr1:150608300 A/G cg18016565 chr1:150552671 MCL1 -0.44 -6.53 -0.34 2.44e-10 Tonsillectomy; CRC cis rs10256972 0.681 rs12702016 chr7:1129392 C/T cg26608667 chr7:1196370 ZFAND2A 0.36 5.63 0.3 3.78e-8 Longevity;Endometriosis; CRC cis rs137699 1.000 rs2049986 chr22:39756854 C/G cg11247378 chr22:39784982 NA 0.35 6.65 0.34 1.21e-10 IgG glycosylation; CRC cis rs875971 0.558 rs4433015 chr7:65639723 A/C cg11764359 chr7:65958608 NA -0.56 -8.75 -0.43 1.13e-16 Aortic root size; CRC cis rs4862750 0.794 rs7672272 chr4:187896774 T/G cg10295955 chr4:187884368 NA -1.06 -28.15 -0.84 1.27e-89 Lobe attachment (rater-scored or self-reported); CRC cis rs3733346 0.529 rs6842493 chr4:914638 T/C cg04824913 chr4:887549 GAK 0.48 6.66 0.34 1.15e-10 Sjögren's syndrome; CRC cis rs921968 0.643 rs613539 chr2:219455967 G/T cg02176678 chr2:219576539 TTLL4 0.49 7.95 0.4 3.08e-14 Mean corpuscular hemoglobin concentration; CRC cis rs3736485 0.903 rs8039835 chr15:51865864 A/G cg08986416 chr15:51914746 DMXL2 -0.45 -6.58 -0.34 1.88e-10 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs3026101 0.671 rs72634032 chr17:5303437 G/A cg25236894 chr17:5323110 RPAIN;NUP88 0.42 6.9 0.36 2.74e-11 Body mass index; CRC cis rs875971 1.000 rs2042133 chr7:65931922 A/G cg12463550 chr7:65579703 CRCP 0.48 6.78 0.35 5.54e-11 Aortic root size; CRC cis rs72848980 0.512 rs56984020 chr10:105386275 C/A cg00126946 chr10:105363258 SH3PXD2A 0.49 6.23 0.32 1.4e-9 White matter hyperintensity burden; CRC cis rs9903692 0.954 rs7224014 chr17:46150861 T/G cg21215337 chr17:46176117 CBX1 0.42 7.79 0.39 8.7e-14 Pulse pressure; CRC cis rs2797160 0.935 rs1739372 chr6:126011325 G/A cg05901451 chr6:126070800 HEY2 0.4 6.2 0.32 1.65e-9 Endometrial cancer; CRC cis rs9910055 0.762 rs6503489 chr17:42246289 G/A cg10896456 chr17:42255109 ASB16;C17orf65 0.44 7.35 0.38 1.6e-12 Total body bone mineral density; CRC cis rs10078 0.571 rs2241597 chr5:480509 A/G cg24955955 chr5:415729 AHRR 0.62 6.27 0.33 1.16e-9 Fat distribution (HIV); CRC cis rs67478160 0.643 rs4906369 chr14:104242458 T/C cg01849466 chr14:104193079 ZFYVE21 -0.5 -9.0 -0.44 1.82e-17 Schizophrenia; CRC trans rs4942242 0.640 rs9533563 chr13:44212127 A/G cg27382691 chr15:76552771 ETFA;TYRO3P -0.49 -6.29 -0.33 1e-9 Response to tocilizumab in rheumatoid arthritis; CRC cis rs7119 0.604 rs2682921 chr15:77865459 C/T cg10437265 chr15:77819839 NA -0.54 -8.97 -0.44 2.24e-17 Type 2 diabetes; CRC cis rs4664308 0.692 rs10497213 chr2:160963603 G/A cg03641300 chr2:160917029 PLA2R1 -0.57 -9.14 -0.45 6.39e-18 Idiopathic membranous nephropathy; CRC cis rs4889855 0.530 rs4477776 chr17:78581765 G/A cg16591659 chr17:78472290 NA -0.4 -6.0 -0.31 5.06e-9 Fractional excretion of uric acid; CRC cis rs2549003 1.000 rs2549003 chr5:131829297 A/G cg02551604 chr5:131831745 NA -0.55 -8.45 -0.42 9.46e-16 Asthma (sex interaction); CRC cis rs7258465 1.000 rs10442 chr19:18545341 A/C cg01065977 chr19:18549689 ISYNA1 -0.41 -6.23 -0.33 1.39e-9 Breast cancer; CRC cis rs11148252 0.846 rs13431 chr13:52987477 G/C cg02158880 chr13:53174818 NA 0.49 7.37 0.38 1.37e-12 Lewy body disease; CRC cis rs6076065 1.000 rs6083105 chr20:23368475 C/A cg11657817 chr20:23433608 CST11 0.36 5.63 0.3 3.78e-8 Facial morphology (factor 15, philtrum width); CRC trans rs7395662 0.504 rs1814158 chr11:48437937 C/T cg03929089 chr4:120376271 NA -0.45 -6.37 -0.33 6.43e-10 HDL cholesterol; CRC cis rs13108904 0.870 rs2291199 chr4:1244267 A/G cg19318889 chr4:1322082 MAEA 0.41 5.94 0.31 7.34e-9 Obesity-related traits; CRC cis rs17767392 0.813 rs8013161 chr14:72021499 G/A cg13720639 chr14:72061746 SIPA1L1 0.5 6.35 0.33 7e-10 Mitral valve prolapse; CRC cis rs9487051 0.768 rs445796 chr6:109520145 T/C cg01475377 chr6:109611718 NA -0.34 -5.86 -0.31 1.12e-8 Reticulocyte fraction of red cells; CRC cis rs3820928 0.967 rs4675113 chr2:227766339 G/A cg11843606 chr2:227700838 RHBDD1 -0.4 -5.74 -0.3 2.11e-8 Pulmonary function; CRC cis rs17376456 0.877 rs13185660 chr5:93336500 G/A cg09848695 chr5:92956644 FAM172A;MIR2277 0.64 5.73 0.3 2.21e-8 Diabetic retinopathy; CRC cis rs7647973 1.000 rs7613491 chr3:49508976 T/C cg07690219 chr3:49449608 TCTA;RHOA 0.53 5.81 0.31 1.46e-8 Menarche (age at onset); CRC cis rs10504229 0.683 rs2101864 chr8:58113226 C/T cg21724239 chr8:58056113 NA 0.5 6.89 0.35 2.89e-11 Developmental language disorder (linguistic errors); CRC cis rs9372498 0.536 rs9489394 chr6:118758234 T/C cg10217327 chr6:118973057 C6orf204 0.51 5.75 0.3 2e-8 Diastolic blood pressure; CRC cis rs4888262 0.545 rs7184754 chr16:74667864 C/T cg01733217 chr16:74700730 RFWD3 0.81 12.32 0.56 6.13e-29 Testicular germ cell tumor; CRC cis rs9393692 0.645 rs6939048 chr6:26327953 G/A cg13736514 chr6:26305472 NA -0.66 -11.64 -0.54 1.81e-26 Educational attainment; CRC cis rs17270561 0.609 rs4132072 chr6:25717843 C/T cg17691542 chr6:26056736 HIST1H1C 0.64 8.21 0.41 5.1e-15 Iron status biomarkers; CRC cis rs13191362 1.000 rs13207671 chr6:162979056 A/G cg23758597 chr6:163146217 PARK2 -0.56 -6.18 -0.32 1.93e-9 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC trans rs6940638 0.956 rs12190473 chr6:27024687 C/T cg06606381 chr12:133084897 FBRSL1 -0.59 -6.46 -0.34 3.79e-10 Intelligence (multi-trait analysis); CRC cis rs736408 0.545 rs6445529 chr3:52662722 T/A cg11645453 chr3:52864694 ITIH4 0.36 6.5 0.34 3.02e-10 Bipolar disorder; CRC cis rs7112925 0.932 rs2282502 chr11:66834252 C/T cg24851651 chr11:66362959 CCS -0.39 -6.76 -0.35 6.16e-11 Height; CRC cis rs4665809 0.556 rs6730311 chr2:26419474 C/T cg25036284 chr2:26402008 FAM59B -0.64 -8.21 -0.41 5.24e-15 Gut microbiome composition (summer); CRC cis rs4743820 0.651 rs10991797 chr9:93930671 A/G cg14446406 chr9:93919335 NA -0.73 -12.98 -0.58 2.17e-31 Ulcerative colitis;Inflammatory bowel disease; CRC cis rs2952156 0.883 rs907089 chr17:37833600 C/T cg07936489 chr17:37558343 FBXL20 -0.41 -5.96 -0.31 6.4e-9 Asthma; CRC cis rs13315871 0.929 rs71311849 chr3:58230809 G/A cg20936604 chr3:58311152 NA -0.64 -6.33 -0.33 8.21e-10 Cholesterol, total; CRC cis rs58688157 0.705 rs36060383 chr11:598723 A/C cg02461776 chr11:598696 PHRF1 0.47 5.96 0.31 6.64e-9 Systemic lupus erythematosus; CRC cis rs9914988 0.778 rs4794837 chr17:27110024 T/C cg16670446 chr17:27188758 MIR451;MIR144 0.55 8.52 0.43 5.75e-16 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs7487075 0.893 rs12317787 chr12:46736729 T/C cg22049899 chr12:47219821 SLC38A4 0.35 6.88 0.35 3.07e-11 Itch intensity from mosquito bite; CRC cis rs4889609 0.834 rs72785520 chr16:31070778 C/T cg02466173 chr16:30829666 NA -0.62 -9.41 -0.46 8.9e-19 Response to metformin (IC50); CRC trans rs1814175 0.616 rs1794139 chr11:49910855 C/T cg15704280 chr7:45808275 SEPT13 -0.94 -16.48 -0.67 6.65e-45 Height; CRC cis rs763121 0.853 rs6001188 chr22:39062194 T/C cg06022373 chr22:39101656 GTPBP1 0.8 12.66 0.57 3.43e-30 Menopause (age at onset); CRC cis rs17401966 0.838 rs12120042 chr1:10345325 A/T cg19773385 chr1:10388646 KIF1B -0.67 -11.09 -0.52 1.66e-24 Hepatocellular carcinoma; CRC cis rs7591163 1.000 rs7574255 chr2:228699884 C/G cg21577049 chr2:228736449 WDR69 0.44 5.9 0.31 8.95e-9 Blood pressure; CRC cis rs10242455 0.571 rs73713594 chr7:99326498 A/G cg18809830 chr7:99032528 PTCD1 -0.96 -7.11 -0.36 7.45e-12 Blood metabolite levels; CRC trans rs1656966 1.000 rs1656966 chr3:186466252 C/T cg20742182 chr15:101629240 NA 0.43 6.49 0.34 3.12e-10 Myopia (pathological); CRC cis rs10504229 0.679 rs6474100 chr8:58031161 G/A cg02725872 chr8:58115012 NA -0.36 -6.18 -0.32 1.91e-9 Developmental language disorder (linguistic errors); CRC cis rs7615952 0.512 rs4646765 chr3:125820707 G/A cg15145296 chr3:125709740 NA -0.57 -6.64 -0.34 1.29e-10 Blood pressure (smoking interaction); CRC cis rs7568458 0.846 rs10179195 chr2:85762761 A/G cg02493740 chr2:85810744 VAMP5 -0.39 -6.16 -0.32 2.11e-9 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg19189012 chr12:56401370 NA 0.4 5.98 0.31 5.9e-9 Intelligence (multi-trait analysis); CRC cis rs747650 0.532 rs7128650 chr11:47047059 A/G cg19486271 chr11:47235900 DDB2 -0.43 -5.79 -0.3 1.64e-8 Acne (severe); CRC cis rs798554 1.000 rs798536 chr7:2766383 G/A cg04166393 chr7:2884313 GNA12 0.49 6.54 0.34 2.3e-10 Height; CRC cis rs1552244 0.872 rs6771931 chr3:10113408 C/G cg13047869 chr3:10149882 C3orf24 0.53 7.31 0.37 2.04e-12 Alzheimer's disease; CRC cis rs4665809 1.000 rs2053367 chr2:26293413 T/C cg25036284 chr2:26402008 FAM59B -0.45 -5.95 -0.31 6.92e-9 Gut microbiome composition (summer); CRC cis rs834811 0.583 rs73168818 chr7:135878903 G/A cg01726295 chr7:135938950 NA 0.34 5.77 0.3 1.82e-8 Post-traumatic stress disorder; CRC cis rs780096 0.506 rs1728922 chr2:27644464 A/C cg17158414 chr2:27665306 KRTCAP3 -0.29 -6.25 -0.33 1.28e-9 Total body bone mineral density; CRC cis rs6604026 1.000 rs6657809 chr1:93293063 G/A cg17283838 chr1:93427260 FAM69A 0.44 5.7 0.3 2.7e-8 Multiple sclerosis; CRC cis rs79839061 0.610 rs78590562 chr4:869715 C/T cg07828340 chr4:882639 GAK 1.12 10.91 0.52 7.06e-24 Intelligence (multi-trait analysis); CRC cis rs13191362 1.000 rs35126854 chr6:163012443 C/T cg23758597 chr6:163146217 PARK2 -0.51 -5.9 -0.31 8.81e-9 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs6088580 0.634 rs6088475 chr20:32964987 T/C cg08999081 chr20:33150536 PIGU -0.62 -11.54 -0.54 4.29e-26 Glomerular filtration rate (creatinine); CRC cis rs7786808 0.536 rs4909210 chr7:158194376 T/C cg01191920 chr7:158217561 PTPRN2 -0.63 -10.16 -0.49 2.82e-21 Obesity-related traits; CRC cis rs12594515 1.000 rs8039622 chr15:45986431 A/G cg22117107 chr15:45993392 NA -0.44 -8.83 -0.44 6.22e-17 Waist circumference;Weight; CRC cis rs600626 0.529 rs10899113 chr11:75468464 T/A cg24262691 chr11:75473276 NA 0.52 7.2 0.37 4.03e-12 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CRC cis rs4746818 0.892 rs12437 chr10:70864065 T/C cg11621586 chr10:70884670 VPS26A 0.59 5.99 0.31 5.45e-9 Left atrial antero-posterior diameter; CRC cis rs1577917 0.958 rs1838955 chr6:86565449 T/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.51 -6.67 -0.35 1.07e-10 Response to antipsychotic treatment; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg25375453 chr3:14219857 LSM3;XPC 0.41 6.45 0.34 4.07e-10 Intelligence (multi-trait analysis); CRC cis rs2274273 0.624 rs7151581 chr14:55788445 A/G cg10130446 chr14:55658398 DLGAP5 0.4 5.65 0.3 3.42e-8 Protein biomarker; CRC cis rs9309473 1.000 rs6745368 chr2:73809974 C/T cg20560298 chr2:73613845 ALMS1 -0.49 -5.87 -0.31 1.06e-8 Metabolite levels; CRC cis rs735539 0.645 rs9550663 chr13:21174053 C/T cg27499820 chr13:21296301 IL17D 0.41 5.82 0.31 1.39e-8 Dental caries; CRC cis rs58904263 1 rs58904263 chr20:30401406 A/AG cg13852791 chr20:30311386 BCL2L1 0.73 12.0 0.55 9.55e-28 Monocyte count; CRC trans rs800082 0.668 rs9821986 chr3:144292701 T/G cg24215973 chr2:240111563 HDAC4 -0.64 -10.19 -0.49 2.22e-21 Smoking behavior; CRC cis rs4285028 0.699 rs2689290 chr3:121585146 C/T cg20356878 chr3:121714668 ILDR1 -0.46 -6.78 -0.35 5.55e-11 Multiple sclerosis; CRC cis rs12682352 0.715 rs332039 chr8:8723651 C/G cg06636001 chr8:8085503 FLJ10661 0.54 7.88 0.4 4.73e-14 Neuroticism; CRC cis rs7618501 1.000 rs2271960 chr3:49878078 A/G cg24308560 chr3:49941425 MST1R -0.44 -6.98 -0.36 1.68e-11 Intelligence (multi-trait analysis); CRC cis rs9916302 0.904 rs2061342 chr17:37405657 T/G cg07936489 chr17:37558343 FBXL20 -0.79 -11.74 -0.54 8.41e-27 Glomerular filtration rate (creatinine); CRC cis rs769267 0.965 rs735273 chr19:19385411 T/C cg20644253 chr19:19431407 KIAA0892;SF4 0.43 5.99 0.31 5.65e-9 Tonsillectomy; CRC cis rs801193 0.660 rs2659897 chr7:66187715 A/G cg00343986 chr7:65444356 GUSB -0.43 -6.21 -0.32 1.58e-9 Aortic root size; CRC cis rs9549367 0.789 rs9549695 chr13:113874814 A/G cg18105134 chr13:113819100 PROZ 0.67 8.96 0.44 2.47e-17 Platelet distribution width; CRC cis rs208520 0.690 rs4386800 chr6:66755242 A/G cg07460842 chr6:66804631 NA 1.04 14.63 0.63 1.08e-37 Exhaled nitric oxide output; CRC cis rs875971 0.861 rs801215 chr7:66011938 A/T cg11764359 chr7:65958608 NA -0.58 -8.65 -0.43 2.27e-16 Aortic root size; CRC cis rs7107174 1.000 rs10899458 chr11:78007451 A/T cg02023728 chr11:77925099 USP35 0.52 7.45 0.38 8.29e-13 Testicular germ cell tumor; CRC cis rs67311347 1.000 rs73078169 chr3:40483798 G/A cg24209194 chr3:40518798 ZNF619 0.42 6.03 0.32 4.34e-9 Renal cell carcinoma; CRC cis rs929354 0.772 rs1182444 chr7:157024510 A/G cg17757837 chr7:157058334 UBE3C -0.75 -12.97 -0.58 2.37e-31 Body mass index; CRC cis rs9462027 0.651 rs34493158 chr6:34753339 T/C cg07306190 chr6:34760872 UHRF1BP1 -0.35 -6.25 -0.33 1.27e-9 Systemic lupus erythematosus; CRC cis rs4601821 0.823 rs4938015 chr11:113264644 C/T cg14159747 chr11:113255604 NA -0.51 -9.89 -0.48 2.32e-20 Alcoholic chronic pancreatitis; CRC cis rs1218582 0.803 rs7531728 chr1:154840516 C/A cg09359103 chr1:154839909 KCNN3 -0.77 -12.95 -0.58 2.86e-31 Prostate cancer; CRC cis rs736408 0.511 rs12637632 chr3:52708073 A/T cg15147215 chr3:52552868 STAB1 -0.63 -10.49 -0.5 2.14e-22 Bipolar disorder; CRC cis rs7811142 0.830 rs6975660 chr7:99975266 A/G cg00814883 chr7:100076585 TSC22D4 -0.68 -8.64 -0.43 2.57e-16 Platelet count; CRC cis rs4481887 0.927 rs4523548 chr1:248472399 G/T cg00666640 chr1:248458726 OR2T12 0.45 7.8 0.4 8.31e-14 Common traits (Other); CRC cis rs1577917 1.000 rs7760207 chr6:86721700 T/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.53 -6.9 -0.36 2.63e-11 Response to antipsychotic treatment; CRC cis rs394563 0.775 rs448420 chr6:149785802 T/C cg03678062 chr6:149772716 ZC3H12D -0.37 -6.42 -0.33 4.69e-10 Dupuytren's disease; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg12672932 chr2:153575114 ARL6IP6;PRPF40A 0.39 6.08 0.32 3.32e-9 Liver disease severity in Alagille syndrome; CRC cis rs4478858 0.735 rs11576603 chr1:31774031 C/T cg07478791 chr1:31886160 SERINC2 -0.4 -5.64 -0.3 3.76e-8 Alcohol dependence; CRC cis rs1799949 1.000 rs12952790 chr17:41299607 A/G cg19454999 chr17:41278357 BRCA1;NBR2 0.55 8.65 0.43 2.28e-16 Menopause (age at onset); CRC cis rs2290159 0.800 rs11711419 chr3:12667784 A/T cg23032965 chr3:12705835 RAF1 0.5 6.4 0.33 5.37e-10 Cholesterol, total; CRC cis rs10411161 0.702 rs6509592 chr19:52393150 G/A cg24794228 chr19:52391166 ZNF577 0.48 5.76 0.3 1.96e-8 Breast cancer; CRC cis rs6674176 0.660 rs6680421 chr1:44408969 A/C cg12908607 chr1:44402522 ARTN 0.61 11.13 0.52 1.27e-24 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Cognitive ability; CRC cis rs4862750 0.872 rs13143414 chr4:187878213 G/A cg07414643 chr4:187882934 NA 0.36 6.39 0.33 5.76e-10 Lobe attachment (rater-scored or self-reported); CRC cis rs7707921 0.881 rs73134747 chr5:81378294 C/T cg07807695 chr5:81608485 ATP6AP1L 0.4 5.74 0.3 2.19e-8 Breast cancer; CRC cis rs763121 0.889 rs4820335 chr22:38935927 C/G cg06544989 chr22:39130855 UNC84B -0.46 -7.23 -0.37 3.37e-12 Menopause (age at onset); CRC cis rs1669338 0.588 rs55959448 chr3:3204000 C/T cg16797762 chr3:3221439 CRBN -0.62 -5.69 -0.3 2.78e-8 White matter integrity; CRC cis rs2032447 0.765 rs1935235 chr6:26067782 C/G cg27635394 chr6:26043820 HIST1H2BB 0.41 5.95 0.31 7.02e-9 Intelligence (multi-trait analysis); CRC cis rs780096 0.526 rs10182937 chr2:27651693 T/C cg21248554 chr2:27665150 KRTCAP3 -0.33 -7.72 -0.39 1.45e-13 Total body bone mineral density; CRC cis rs3812565 0.506 rs8413 chr9:139323311 T/C cg14019695 chr9:139328340 INPP5E 0.44 6.43 0.33 4.48e-10 Granulocyte percentage of myeloid white cells; CRC cis rs6461049 0.765 rs4719431 chr7:2140312 T/C cg14004847 chr7:1930337 MAD1L1 -0.4 -5.68 -0.3 3.02e-8 Schizophrenia; CRC cis rs2000999 0.515 rs2854956 chr16:72115238 A/T cg23815491 chr16:72088622 HP 0.57 8.71 0.43 1.48e-16 Total cholesterol levels;Cholesterol, total;Blood protein levels;LDL cholesterol levels;Haptoglobin levels;LDL cholesterol; CRC cis rs6964587 0.869 rs34791781 chr7:91532720 C/T cg17063962 chr7:91808500 NA -0.74 -12.25 -0.56 1.1e-28 Breast cancer; CRC cis rs6835098 1.000 rs1054497 chr4:174089048 A/T cg08422745 chr4:174089978 GALNT7 0.94 16.26 0.67 5.01e-44 Dementia and core Alzheimer's disease neuropathologic changes; CRC cis rs12956045 0.597 rs11662811 chr18:13855983 C/T cg15534052 chr18:13871104 NA -0.33 -5.98 -0.31 5.7e-9 Response to bronchodilator in chronic obstructive pulmonary disease (change in FEV1); CRC trans rs72991 0.643 rs99673 chr11:121255108 C/T cg27192990 chr6:129479024 LAMA2 -0.37 -5.99 -0.31 5.53e-9 Response to tocilizumab in rheumatoid arthritis; CRC cis rs629535 0.821 rs660144 chr8:70035629 T/C cg26132723 chr8:70041827 NA 0.35 5.68 0.3 3.03e-8 Dupuytren's disease; CRC cis rs798766 1.000 rs798719 chr4:1698183 C/T cg25714306 chr4:1656736 FAM53A -0.34 -6.0 -0.31 5.17e-9 Bladder cancer;Urinary bladder cancer; CRC cis rs11255291 1.000 rs2182652 chr10:7735876 C/T cg00997801 chr10:7671259 ITIH5 -0.41 -5.92 -0.31 8.11e-9 Ovarian reserve; CRC cis rs617791 0.508 rs10791837 chr11:65774596 C/T cg27068330 chr11:65405492 SIPA1 -0.48 -6.65 -0.34 1.23e-10 Breast cancer; CRC cis rs11212617 0.967 rs228588 chr11:108113331 C/G cg12106634 chr11:108092400 ATM;NPAT 0.39 5.72 0.3 2.35e-8 Response to metformin in type 2 diabetes (glycemic); CRC cis rs7811142 1.000 rs4463351 chr7:100078226 G/A cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.92 12.27 0.56 9.74e-29 Platelet count; CRC cis rs561341 1.000 rs117979353 chr17:30272866 A/G cg12193833 chr17:30244370 NA -0.75 -8.72 -0.43 1.4e-16 Hip circumference adjusted for BMI; CRC cis rs7044106 0.791 rs2416799 chr9:123480866 G/T cg14255062 chr9:123606675 PSMD5;LOC253039 0.49 7.43 0.38 9.15e-13 Hip circumference adjusted for BMI; CRC cis rs861020 0.604 rs3766612 chr1:210020013 G/T cg09163369 chr1:210001066 C1orf107 -0.6 -7.84 -0.4 6.19e-14 Orofacial clefts; CRC cis rs1448094 0.802 rs7397730 chr12:86416212 T/C cg02569458 chr12:86230093 RASSF9 0.39 6.52 0.34 2.7e-10 Major depressive disorder; CRC trans rs970548 0.697 rs11239540 chr10:45999209 T/C cg14222797 chr10:16859974 RSU1 -0.67 -6.52 -0.34 2.66e-10 Total cholesterol levels;Cholesterol, total;HDL cholesterol;HDL cholesterol levels; CRC cis rs1950500 0.509 rs12882558 chr14:24819233 G/A cg22990158 chr14:24802150 ADCY4 -0.33 -5.61 -0.3 4.38e-8 Height; CRC cis rs10450586 0.799 rs11029901 chr11:27287108 A/G cg10370305 chr11:27303972 NA 0.37 5.79 0.3 1.68e-8 Total body bone mineral density; CRC cis rs6504622 0.539 rs4968248 chr17:44993128 G/A cg16759221 chr17:45003025 GOSR2 0.54 8.68 0.43 1.9e-16 Orofacial clefts; CRC cis rs947211 0.750 rs5014255 chr1:205753870 C/A cg14893161 chr1:205819251 PM20D1 0.43 6.07 0.32 3.47e-9 Parkinson's disease; CRC cis rs9443645 0.901 rs2050659 chr6:79734369 A/C cg11833968 chr6:79620685 NA -0.36 -6.09 -0.32 3.2e-9 Intelligence (multi-trait analysis); CRC cis rs644799 0.511 rs12791736 chr11:95475399 C/G cg25622487 chr11:95524042 FAM76B;CEP57 0.49 6.7 0.35 9.3e-11 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs12134245 0.742 rs17501381 chr1:92003919 A/G cg25838465 chr1:92012736 NA -0.68 -12.45 -0.57 1.99e-29 Breast cancer; CRC cis rs10782582 0.609 rs1689270 chr1:76390937 A/G cg03433033 chr1:76189801 ACADM -0.42 -6.03 -0.32 4.4e-9 Daytime sleep phenotypes; CRC cis rs8062405 1.000 rs8055138 chr16:28891465 C/T cg16576597 chr16:28551801 NUPR1 0.48 6.83 0.35 4e-11 Cognitive ability (multi-trait analysis);Cognitive ability; CRC cis rs400736 0.894 rs225092 chr1:8036075 G/C cg25007680 chr1:8021821 PARK7 0.54 7.54 0.38 4.53e-13 Response to antidepressants and depression; CRC cis rs10504229 0.679 rs17804870 chr8:58158071 A/G cg11062466 chr8:58055876 NA 0.53 6.17 0.32 1.97e-9 Developmental language disorder (linguistic errors); CRC cis rs10927875 0.557 rs1572381 chr1:16344494 G/A cg24140574 chr1:16342155 HSPB7 0.47 6.7 0.35 8.99e-11 Dilated cardiomyopathy; CRC cis rs7705042 0.865 rs4912623 chr5:141505462 T/A cg07392085 chr5:141489673 NDFIP1 0.46 7.27 0.37 2.59e-12 Asthma; CRC cis rs6860806 0.507 rs272891 chr5:131664394 G/T cg22638593 chr5:131593259 PDLIM4 0.38 6.28 0.33 1.09e-9 Breast cancer; CRC cis rs4743820 0.620 rs55934624 chr9:93917285 T/G cg14446406 chr9:93919335 NA 0.77 13.47 0.6 2.94e-33 Ulcerative colitis;Inflammatory bowel disease; CRC cis rs875971 0.862 rs7798630 chr7:65771479 G/C cg12463550 chr7:65579703 CRCP -0.5 -6.78 -0.35 5.73e-11 Aortic root size; CRC cis rs72615157 0.595 rs112241539 chr7:99847237 C/T cg13153964 chr7:100026424 MEPCE;ZCWPW1 0.83 9.5 0.46 4.66e-19 Lung function (FEV1/FVC); CRC cis rs17331151 0.505 rs79979130 chr3:52551010 C/T cg27565382 chr3:53032988 SFMBT1 0.79 5.8 0.3 1.59e-8 Immune reponse to smallpox (secreted IL-2); CRC cis rs6951245 0.554 rs2070118 chr7:1132505 G/A cg24642844 chr7:1081250 C7orf50 -0.51 -6.56 -0.34 2.06e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs6502050 0.835 rs7503189 chr17:80099486 C/A cg19223190 chr17:80058835 NA 0.4 6.36 0.33 6.88e-10 Life satisfaction; CRC cis rs11148252 0.740 rs7981050 chr13:52755149 C/T cg02158880 chr13:53174818 NA 0.46 6.72 0.35 8.16e-11 Lewy body disease; CRC cis rs1891275 0.515 rs1986941 chr10:93444343 C/T cg07889827 chr10:93443413 NA -0.39 -6.78 -0.35 5.48e-11 Intelligence (multi-trait analysis); CRC cis rs2243480 0.803 rs423187 chr7:65509499 G/C cg12463550 chr7:65579703 CRCP 0.76 6.72 0.35 8.14e-11 Diabetic kidney disease; CRC cis rs7623687 0.892 rs73088122 chr3:49432404 C/T cg19401529 chr3:49056140 DALRD3 0.53 6.05 0.32 3.92e-9 Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease);Coronary artery disease; CRC cis rs7647973 0.771 rs9865051 chr3:49166069 C/T cg20833759 chr3:49053208 WDR6;DALRD3 0.72 10.36 0.5 5.91e-22 Menarche (age at onset); CRC trans rs60843830 1.000 rs3791221 chr2:226933 A/G cg11347411 chr7:150020925 ACTR3C;LRRC61 0.61 9.59 0.47 2.22e-19 Spherical equivalent (joint analysis main effects and education interaction); CRC cis rs4919694 0.615 rs78384860 chr10:105003019 G/T cg04362960 chr10:104952993 NT5C2 1.11 9.31 0.46 1.89e-18 Arsenic metabolism; CRC cis rs7927771 1.000 rs12361031 chr11:47783076 G/A cg18512352 chr11:47633146 NA -0.49 -9.48 -0.46 5.08e-19 Subjective well-being; CRC cis rs7208859 0.623 rs55638872 chr17:29149552 G/C cg19761014 chr17:28927070 LRRC37B2 0.58 5.85 0.31 1.16e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs10504229 0.593 rs12155520 chr8:58014318 C/T cg02725872 chr8:58115012 NA -0.52 -7.24 -0.37 3.13e-12 Developmental language disorder (linguistic errors); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg07210462 chr1:39324918 RRAGC 0.44 6.42 0.33 4.82e-10 Intelligence (multi-trait analysis); CRC cis rs644799 0.511 rs10831420 chr11:95478209 T/C cg25622487 chr11:95524042 FAM76B;CEP57 0.48 6.53 0.34 2.51e-10 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs10883723 0.810 rs7094366 chr10:104274730 C/G cg22532475 chr10:104410764 TRIM8 -0.36 -6.72 -0.35 8.27e-11 Allergic disease (asthma, hay fever or eczema); CRC cis rs6547741 1.000 rs1528402 chr2:27857517 G/A cg27432699 chr2:27873401 GPN1 0.73 13.07 0.58 1.02e-31 Oral cavity cancer; CRC cis rs7618915 0.501 rs1468638 chr3:52748058 T/C cg11645453 chr3:52864694 ITIH4 0.37 6.53 0.34 2.57e-10 Bipolar disorder; CRC cis rs7843479 0.601 rs11135764 chr8:21814004 A/G cg16476235 chr8:21771668 DOK2 0.36 6.19 0.32 1.74e-9 Mean corpuscular volume; CRC cis rs9300255 0.602 rs6488864 chr12:123618362 G/C cg00376283 chr12:123451042 ABCB9 0.6 7.16 0.37 5.35e-12 Neutrophil percentage of white cells; CRC cis rs490234 0.812 rs13286111 chr9:128429951 A/T cg14078157 chr9:128172775 NA -0.36 -5.8 -0.3 1.55e-8 Mean arterial pressure; CRC cis rs2836974 0.897 rs8128102 chr21:40606414 G/A cg11890956 chr21:40555474 PSMG1 1.08 18.38 0.71 1.99e-52 Cognitive function; CRC cis rs1577917 1.000 rs4706254 chr6:86602813 G/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.51 -6.88 -0.35 3.05e-11 Response to antipsychotic treatment; CRC cis rs1348850 0.874 rs6742951 chr2:178340766 G/C cg22681709 chr2:178499509 PDE11A -0.42 -7.39 -0.38 1.25e-12 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs2842992 0.662 rs2273826 chr6:160211421 A/G cg16489826 chr6:160211363 TCP1;MRPL18 0.61 8.99 0.44 1.94e-17 Age-related macular degeneration (geographic atrophy); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg17782706 chr4:184580436 C4orf41;RWDD4A 0.47 6.71 0.35 8.76e-11 Response to antipsychotic treatment; CRC cis rs3087591 0.960 rs4795587 chr17:29587917 A/C cg24425628 chr17:29625626 OMG;NF1 -0.76 -14.03 -0.61 2.19e-35 Hip circumference; CRC cis rs3617 0.573 rs12492391 chr3:52912296 C/A cg10802521 chr3:52805072 NEK4 -0.38 -5.85 -0.31 1.21e-8 Red blood cell count;Autism spectrum disorder or schizophrenia; CRC cis rs2404602 0.530 rs11072614 chr15:76967205 G/A cg23625390 chr15:77176239 SCAPER -0.77 -10.86 -0.51 1.07e-23 Blood metabolite levels; CRC cis rs4838594 0.563 rs3853762 chr10:49678456 G/C cg17291251 chr10:49678358 ARHGAP22 0.46 7.4 0.38 1.15e-12 Daytime sleep phenotypes; CRC cis rs9372498 0.536 rs62424175 chr6:118797381 T/A cg15382696 chr6:118971807 C6orf204 0.57 7.06 0.36 1.02e-11 Diastolic blood pressure; CRC cis rs612683 0.824 rs17454919 chr1:100830370 A/G cg06223162 chr1:101003688 GPR88 0.36 6.46 0.34 3.79e-10 Breast cancer; CRC cis rs881375 0.678 rs7021049 chr9:123683982 G/T cg09419670 chr9:123605666 PSMD5;LOC253039 0.5 8.04 0.41 1.62e-14 Rheumatoid arthritis; CRC cis rs12900413 0.687 rs28752094 chr15:90311645 G/A cg24249390 chr15:90295951 MESP1 -0.58 -9.26 -0.45 2.81e-18 Coronary artery aneurysm in Kawasaki disease; CRC cis rs6089584 0.606 rs7270666 chr20:60577598 C/T cg06108461 chr20:60628389 TAF4 -0.62 -10.68 -0.51 4.55e-23 Body mass index; CRC trans rs9858542 0.953 rs35261698 chr3:49537839 C/G cg21582582 chr3:182698605 DCUN1D1 -0.51 -6.43 -0.33 4.42e-10 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs6700896 0.931 rs1938497 chr1:66100450 G/A cg04111102 chr1:66153794 NA 0.32 5.67 0.3 3.12e-8 C-reactive protein;Mean corpuscular volume;Mean corpuscular hemoglobin; CRC cis rs1448094 0.842 rs12809288 chr12:86455427 C/T cg18827107 chr12:86230957 RASSF9 0.36 5.74 0.3 2.19e-8 Major depressive disorder; CRC trans rs9409565 0.826 rs2769813 chr9:97151194 C/T cg05679027 chr9:99775184 HIATL2 0.43 6.69 0.35 9.42e-11 Colorectal cancer (alcohol consumption interaction); CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg13101865 chr20:3154899 NA 0.45 6.0 0.31 5.19e-9 Thyroid stimulating hormone; CRC cis rs7632954 0.567 rs9813104 chr3:8534493 C/G cg03495237 chr3:8533978 NA 0.34 6.13 0.32 2.54e-9 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs4862750 0.832 rs6419953 chr4:187900509 T/A cg07414643 chr4:187882934 NA 0.39 6.95 0.36 1.94e-11 Lobe attachment (rater-scored or self-reported); CRC cis rs853679 0.517 rs9393893 chr6:28109262 T/C cg21251018 chr6:28226885 NKAPL 0.48 6.17 0.32 2.02e-9 Depression; CRC trans rs13046373 0.905 rs4816372 chr21:32077414 A/T cg02119693 chr2:192161142 MYO1B -0.4 -6.18 -0.32 1.94e-9 HDL cholesterol; CRC cis rs7666738 0.830 rs35915560 chr4:98978649 C/T cg17366294 chr4:99064904 C4orf37 0.44 7.38 0.38 1.28e-12 Colonoscopy-negative controls vs population controls; CRC cis rs6089584 0.850 rs6089634 chr20:60632566 T/C cg23463467 chr20:60627584 TAF4 0.36 6.33 0.33 7.98e-10 Body mass index; CRC cis rs9487051 1.000 rs9400272 chr6:109616762 A/G cg21918786 chr6:109611834 NA -0.38 -6.72 -0.35 8.26e-11 Reticulocyte fraction of red cells; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg19000349 chr2:75061841 HK2 0.43 6.05 0.32 4.04e-9 Response to antipsychotic treatment; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg00523012 chr19:13264324 IER2 0.36 5.99 0.31 5.63e-9 Liver disease severity in Alagille syndrome; CRC cis rs2549003 1.000 rs2549007 chr5:131826875 T/C cg00255919 chr5:131827918 IRF1 -0.59 -11.53 -0.54 4.46e-26 Asthma (sex interaction); CRC cis rs2011503 1.000 rs4808968 chr19:19644402 C/T cg11584989 chr19:19387371 SF4 0.59 6.53 0.34 2.48e-10 Bipolar disorder; CRC cis rs9381040 0.610 rs6940462 chr6:41020223 G/A cg04346459 chr6:41068666 NFYA;LOC221442 -0.41 -6.2 -0.32 1.67e-9 Alzheimer's disease (late onset); CRC cis rs9463078 0.803 rs9463083 chr6:45272062 T/G cg25276700 chr6:44698697 NA -0.28 -6.73 -0.35 7.77e-11 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; CRC cis rs4819052 1.000 rs9984901 chr21:46663952 C/T cg02159808 chr21:46707872 POFUT2;LOC642852 0.63 7.69 0.39 1.7e-13 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs3733585 0.579 rs4235353 chr4:10122934 C/T cg11266682 chr4:10021025 SLC2A9 -0.47 -8.44 -0.42 1.02e-15 Cleft plate (environmental tobacco smoke interaction); CRC cis rs9549367 0.826 rs9549710 chr13:113898064 A/C cg18105134 chr13:113819100 PROZ -0.75 -10.68 -0.51 4.7e-23 Platelet distribution width; CRC cis rs10744422 1.000 rs7294991 chr12:123286780 C/T cg25930673 chr12:123319894 HIP1R -0.57 -5.98 -0.31 5.97e-9 Schizophrenia; CRC cis rs870825 0.616 rs7680639 chr4:185652915 C/T cg04058563 chr4:185651563 MLF1IP -0.69 -8.69 -0.43 1.68e-16 Blood protein levels; CRC cis rs40363 0.645 rs6501177 chr16:3523681 C/T cg21433313 chr16:3507492 NAT15 0.59 8.65 0.43 2.31e-16 Tuberculosis; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg14166846 chr1:220268091 IARS2 0.47 6.3 0.33 9.53e-10 Thyroid stimulating hormone; CRC cis rs834811 0.602 rs17243535 chr7:135886453 T/C cg01726295 chr7:135938950 NA 0.36 6.11 0.32 2.74e-9 Post-traumatic stress disorder; CRC cis rs6952808 0.792 rs12537914 chr7:1948359 C/T cg21782813 chr7:2030301 MAD1L1 0.44 7.41 0.38 1.04e-12 Bipolar disorder and schizophrenia; CRC cis rs6570726 0.905 rs375692 chr6:145840368 A/G cg05347473 chr6:146136440 FBXO30 0.38 5.91 0.31 8.59e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs11098499 0.954 rs4345162 chr4:120312959 G/A cg24375607 chr4:120327624 NA 0.51 7.86 0.4 5.5e-14 Corneal astigmatism; CRC cis rs1799949 1.000 rs8176265 chr17:41213996 C/T cg23758822 chr17:41437982 NA 0.81 13.59 0.6 1.1e-33 Menopause (age at onset); CRC cis rs4713118 0.955 rs9468200 chr6:27683063 T/A cg03623178 chr6:28175578 NA 0.64 8.29 0.42 2.88e-15 Parkinson's disease; CRC trans rs1737890 0.623 rs6057570 chr20:30988098 A/T cg05428433 chr16:3614067 NLRC3 -0.4 -5.96 -0.31 6.54e-9 Chronic obstructive pulmonary disease; CRC cis rs921968 0.607 rs529474 chr2:219463283 C/T cg02176678 chr2:219576539 TTLL4 0.49 7.95 0.4 3.08e-14 Mean corpuscular hemoglobin concentration; CRC cis rs9660180 0.620 rs3817856 chr1:1663831 C/T cg27541892 chr1:1571801 CDK11B -0.6 -8.58 -0.43 3.82e-16 Body mass index; CRC cis rs7833790 0.777 rs7815272 chr8:82691809 T/G cg27398817 chr8:82754497 SNX16 -0.49 -5.85 -0.31 1.17e-8 Diastolic blood pressure; CRC cis rs3820068 0.603 rs41270279 chr1:15988878 A/G cg13390004 chr1:15929781 NA 0.52 7.28 0.37 2.49e-12 Systolic blood pressure; CRC cis rs13191362 0.808 rs13217502 chr6:163231414 C/T cg21926612 chr6:163149169 PACRG;PARK2 0.7 8.93 0.44 3.17e-17 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs2836974 0.897 rs4817996 chr21:40525759 G/C cg11644478 chr21:40555479 PSMG1 0.82 13.39 0.59 6.26e-33 Cognitive function; CRC cis rs875971 0.638 rs801205 chr7:66022144 C/A cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.43 -6.46 -0.34 3.8e-10 Aortic root size; CRC cis rs10486722 0.606 rs1124538 chr7:41778055 C/T cg22138096 chr7:41772439 LOC285954 0.43 5.76 0.3 1.96e-8 Pit-and-Fissure caries; CRC cis rs875971 1.000 rs1144894 chr7:65542894 A/G cg11764359 chr7:65958608 NA -0.6 -9.5 -0.46 4.46e-19 Aortic root size; CRC cis rs6952808 0.692 rs11773316 chr7:2027354 C/T cg02951883 chr7:2050386 MAD1L1 -0.79 -12.97 -0.58 2.43e-31 Bipolar disorder and schizophrenia; CRC cis rs612683 0.524 rs11166456 chr1:100925633 C/T cg06223162 chr1:101003688 GPR88 0.32 5.66 0.3 3.37e-8 Breast cancer; CRC cis rs713587 0.563 rs1529897 chr2:25086827 T/G cg22495460 chr2:25135724 ADCY3 -0.9 -17.66 -0.7 1.51e-49 Body mass index in non-asthmatics; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg18607491 chr14:51706792 TMX1 0.44 7.06 0.36 9.75e-12 Liver disease severity in Alagille syndrome; CRC cis rs2976388 0.609 rs2717603 chr8:143803193 T/C cg20041105 chr8:143859282 LYNX1 0.45 8.09 0.41 1.16e-14 Urinary tract infection frequency; CRC cis rs933688 1.000 rs10073935 chr5:90742188 A/G cg26981201 chr5:90679533 LOC100129716;ARRDC3 1.0 16.26 0.67 4.86e-44 Smoking behavior; CRC cis rs6951245 0.935 rs61753396 chr7:1105372 A/G cg26224354 chr7:1096374 C7orf50;GPR146 -0.94 -12.26 -0.56 9.81e-29 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs7312774 0.618 rs4964513 chr12:107375758 T/C cg16260113 chr12:107380972 MTERFD3 1.09 9.98 0.48 1.12e-20 Severe influenza A (H1N1) infection; CRC cis rs3824867 0.920 rs4282946 chr11:47456202 G/A cg05585544 chr11:47624801 NA -0.4 -6.36 -0.33 6.58e-10 Mean corpuscular hemoglobin; CRC cis rs8180040 0.966 rs17784882 chr3:47544003 C/A cg10298567 chr3:47292165 KIF9 0.39 6.34 0.33 7.54e-10 Colorectal cancer; CRC cis rs9916302 0.706 rs801427 chr17:37436711 A/G cg07936489 chr17:37558343 FBXL20 -0.83 -10.44 -0.5 3.18e-22 Glomerular filtration rate (creatinine); CRC cis rs801193 0.935 rs2659916 chr7:66151352 C/G cg11764359 chr7:65958608 NA 0.54 8.3 0.42 2.72e-15 Aortic root size; CRC cis rs67478160 0.634 rs2295140 chr14:104216293 C/T cg01849466 chr14:104193079 ZFYVE21 -0.55 -10.33 -0.49 7.41e-22 Schizophrenia; CRC cis rs7615952 0.599 rs12496921 chr3:125701948 C/G cg02772935 chr3:125709198 NA -0.49 -5.73 -0.3 2.27e-8 Blood pressure (smoking interaction); CRC cis rs2717559 0.522 rs10956987 chr8:143886613 T/C cg01489032 chr8:143877656 NA 0.36 5.99 0.31 5.46e-9 Urinary tract infection frequency; CRC cis rs250677 0.687 rs168750 chr5:148446756 A/G cg18129178 chr5:148520854 ABLIM3 -0.36 -5.64 -0.3 3.72e-8 Breast cancer; CRC cis rs7811142 0.943 rs10241492 chr7:99994813 A/G cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.61 7.78 0.39 9.58e-14 Platelet count; CRC cis rs4664293 0.642 rs6732598 chr2:160646881 G/A cg08347373 chr2:160653686 CD302 0.51 8.76 0.43 1.08e-16 Monocyte percentage of white cells; CRC cis rs11098499 0.535 rs10005542 chr4:120268302 T/C cg09307838 chr4:120376055 NA 0.62 9.66 0.47 1.37e-19 Corneal astigmatism; CRC cis rs4930103 0.935 rs2071095 chr11:2020627 C/A cg06197492 chr11:2016605 H19 0.41 6.42 0.33 4.72e-10 DNA methylation (parent-of-origin);DNA methylation (variation); CRC cis rs7412746 0.658 rs6669855 chr1:150861229 C/T cg18016565 chr1:150552671 MCL1 0.43 5.94 0.31 7.37e-9 Melanoma; CRC cis rs79839061 0.518 rs11734537 chr4:869174 A/G cg07828340 chr4:882639 GAK 1.13 11.0 0.52 3.68e-24 Intelligence (multi-trait analysis); CRC cis rs791888 1.000 rs791882 chr10:89408258 C/T cg13926569 chr10:89418898 PAPSS2 -0.46 -6.7 -0.35 9.12e-11 Magnesium levels; CRC cis rs17253792 0.822 rs17253723 chr14:56154015 A/G cg01858014 chr14:56050164 KTN1 -0.87 -7.03 -0.36 1.17e-11 Putamen volume; CRC cis rs7647973 1.000 rs74471041 chr3:49542543 T/G cg07636037 chr3:49044803 WDR6 -0.65 -7.65 -0.39 2.18e-13 Menarche (age at onset); CRC cis rs514406 0.708 rs480299 chr1:53320274 G/T cg25767906 chr1:53392781 SCP2 -0.53 -8.35 -0.42 1.86e-15 Monocyte count; CRC trans rs531930 0.587 rs332611 chr6:124713527 C/T cg10053779 chr10:121497344 INPP5F -0.38 -6.24 -0.33 1.36e-9 Celiac disease; CRC trans rs12599106 0.839 rs3853177 chr16:34498532 A/G cg11235426 chr6:292522 DUSP22 -0.54 -7.62 -0.39 2.69e-13 Menopause (age at onset); CRC cis rs7615952 0.641 rs12488180 chr3:125782236 C/T cg18479299 chr3:125709523 NA -0.55 -6.6 -0.34 1.66e-10 Blood pressure (smoking interaction); CRC cis rs6912958 0.535 rs1753153 chr6:88032834 T/G cg12350822 chr6:88032061 C6orf162;GJB7 0.5 10.16 0.49 2.87e-21 Monocyte percentage of white cells; CRC cis rs2976388 0.590 rs3758082 chr8:143824483 A/G cg04969067 chr8:143858791 LYNX1 -0.42 -6.64 -0.34 1.28e-10 Urinary tract infection frequency; CRC trans rs11098499 0.866 rs6857892 chr4:120282696 G/T cg25214090 chr10:38739885 LOC399744 0.61 9.66 0.47 1.39e-19 Corneal astigmatism; CRC cis rs1865760 0.964 rs9379802 chr6:25933898 T/A cg12310025 chr6:25882481 NA -0.41 -5.74 -0.3 2.1e-8 Height; CRC cis rs992157 0.835 rs7585702 chr2:219146607 T/C cg04731861 chr2:219085781 ARPC2 0.33 6.94 0.36 2.07e-11 Colorectal cancer; CRC cis rs9916302 0.784 rs4795361 chr17:37573446 G/A cg00129232 chr17:37814104 STARD3 -0.54 -8.05 -0.41 1.48e-14 Glomerular filtration rate (creatinine); CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg09068198 chr2:65357064 RAB1A 0.56 7.31 0.37 2.07e-12 Thyroid stimulating hormone; CRC trans rs61931739 0.517 rs11052964 chr12:34010996 G/C cg26384229 chr12:38710491 ALG10B 0.54 6.87 0.35 3.15e-11 Morning vs. evening chronotype; CRC cis rs9326248 0.559 rs476399 chr11:116733728 T/C cg10398005 chr11:117014888 PAFAH1B2 -0.37 -5.61 -0.3 4.35e-8 Blood protein levels; CRC trans rs9868809 0.881 rs2310996 chr3:48671834 T/C cg03060546 chr3:49711283 APEH -0.52 -6.01 -0.31 4.84e-9 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; CRC cis rs1862618 0.853 rs832582 chr5:56177743 G/A cg18230493 chr5:56204884 C5orf35 -0.75 -9.27 -0.45 2.61e-18 Initial pursuit acceleration; CRC cis rs2976388 0.578 rs3758081 chr8:143824373 A/G cg24046110 chr8:143859143 LYNX1 -0.44 -6.72 -0.35 8.05e-11 Urinary tract infection frequency; CRC cis rs4332037 0.539 rs55773130 chr7:2070554 T/C cg02825527 chr7:2087843 MAD1L1 -0.46 -5.62 -0.3 4.15e-8 Bipolar disorder; CRC cis rs7927771 0.832 rs10838699 chr11:47386073 T/C cg20307385 chr11:47447363 PSMC3 0.62 9.22 0.45 3.6e-18 Subjective well-being; CRC cis rs9916302 0.904 rs2338800 chr17:37498149 C/G cg00129232 chr17:37814104 STARD3 0.55 8.29 0.42 3.01e-15 Glomerular filtration rate (creatinine); CRC cis rs72634258 0.786 rs6682709 chr1:8173796 A/C cg26816564 chr1:7831052 VAMP3 -0.46 -5.63 -0.3 3.89e-8 Inflammatory bowel disease; CRC cis rs7937682 0.575 rs7107213 chr11:111750430 A/G cg09085632 chr11:111637200 PPP2R1B 0.94 15.49 0.65 4.78e-41 Primary sclerosing cholangitis; CRC cis rs2243480 0.803 rs403089 chr7:65517723 T/C cg25985355 chr7:65971099 NA -0.54 -6.14 -0.32 2.35e-9 Diabetic kidney disease; CRC cis rs4665809 0.938 rs4665822 chr2:26312555 C/G cg26119090 chr2:26468346 HADHA;HADHB -0.62 -7.94 -0.4 3.22e-14 Gut microbiome composition (summer); CRC cis rs3087591 1.000 rs2905795 chr17:29547601 A/G cg24425628 chr17:29625626 OMG;NF1 0.81 15.27 0.64 3.62e-40 Hip circumference; CRC cis rs9381040 0.610 rs6919961 chr6:41020361 T/A cg03644281 chr6:41068752 NFYA;LOC221442 -0.45 -6.42 -0.33 4.82e-10 Alzheimer's disease (late onset); CRC cis rs7412746 0.524 rs58304714 chr1:150831561 T/A cg10589385 chr1:150898437 SETDB1 0.32 6.52 0.34 2.59e-10 Melanoma; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg09071838 chr13:25497213 CENPJ 0.42 6.65 0.34 1.22e-10 Liver disease severity in Alagille syndrome; CRC cis rs79349575 0.811 rs80032154 chr17:47014992 C/A cg22482690 chr17:47019901 SNF8 0.46 7.5 0.38 6.07e-13 Type 2 diabetes; CRC cis rs7959452 0.868 rs10784774 chr12:69737879 C/T cg22834771 chr12:69754056 YEATS4 0.45 6.51 0.34 2.86e-10 Blood protein levels; CRC cis rs8114671 0.562 rs4911163 chr20:33470694 C/T cg07148914 chr20:33460835 GGT7 0.36 6.01 0.31 4.96e-9 Height; CRC cis rs2072510 0.618 rs12302993 chr12:96393261 A/G cg22491680 chr12:96389547 HAL -0.47 -6.45 -0.34 3.88e-10 Metabolite levels (small molecules and protein measures); CRC cis rs9443645 0.901 rs4147183 chr6:79557046 C/G cg05283184 chr6:79620031 NA -0.57 -9.17 -0.45 5.23e-18 Intelligence (multi-trait analysis); CRC cis rs10870270 0.784 rs10430614 chr10:133748640 C/T cg08754478 chr10:133766260 PPP2R2D 0.62 9.12 0.45 7.57e-18 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; CRC cis rs710216 0.843 rs2297972 chr1:43418026 C/T cg03128534 chr1:43423976 SLC2A1 -0.46 -6.17 -0.32 1.97e-9 Red cell distribution width; CRC trans rs7395662 0.553 rs4882155 chr11:48705801 T/C cg03929089 chr4:120376271 NA -0.49 -7.18 -0.37 4.75e-12 HDL cholesterol; CRC cis rs11587400 0.593 rs2336365 chr1:115175415 G/T cg12756093 chr1:115239321 AMPD1 -0.44 -6.12 -0.32 2.7e-9 Autism; CRC cis rs727563 0.569 rs73178647 chr22:41964168 G/A cg06481639 chr22:41940642 POLR3H -0.56 -5.95 -0.31 6.96e-9 Crohn's disease;Inflammatory bowel disease; CRC cis rs6951245 1.000 rs79683221 chr7:1096139 A/G cg04025307 chr7:1156635 C7orf50 0.63 6.74 0.35 7.02e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs3736485 0.844 rs76092251 chr15:51803193 A/G cg08986416 chr15:51914746 DMXL2 -0.49 -7.13 -0.37 6.27e-12 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs8180040 0.593 rs4018905 chr3:47138170 A/G cg27129171 chr3:47204927 SETD2 0.72 11.37 0.53 1.78e-25 Colorectal cancer; CRC cis rs6460942 0.915 rs75158182 chr7:12456059 C/T cg20607287 chr7:12443886 VWDE -0.66 -6.93 -0.36 2.17e-11 Coronary artery disease; CRC cis rs6502050 0.835 rs6502067 chr17:80111205 A/G cg11859384 chr17:80120422 CCDC57 -0.37 -5.85 -0.31 1.16e-8 Life satisfaction; CRC cis rs6860806 0.661 rs4705929 chr5:131584178 G/T cg04518342 chr5:131593106 PDLIM4 0.45 8.39 0.42 1.5e-15 Breast cancer; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg13504215 chr3:30648325 TGFBR2 0.36 5.98 0.31 5.86e-9 Liver disease severity in Alagille syndrome; CRC cis rs3768617 0.966 rs10911253 chr1:183086190 T/C ch.1.3577855R chr1:183094577 LAMC1 0.61 9.28 0.46 2.36e-18 Fuchs's corneal dystrophy; CRC cis rs6952808 0.582 rs11763870 chr7:2027448 T/C cg14004847 chr7:1930337 MAD1L1 0.43 6.15 0.32 2.29e-9 Bipolar disorder and schizophrenia; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg00157855 chr7:35734423 HERPUD2 0.42 6.39 0.33 5.7e-10 Intelligence (multi-trait analysis); CRC trans rs9858542 0.953 rs9837027 chr3:49597013 C/T cg21665057 chr3:196295764 WDR53;FBXO45 -0.68 -9.36 -0.46 1.29e-18 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs2836974 0.897 rs8132568 chr21:40527916 C/T cg06238570 chr21:40685208 BRWD1 0.71 10.11 0.49 4.09e-21 Cognitive function; CRC cis rs5753618 0.561 rs4820963 chr22:31698166 C/T cg07713946 chr22:31675144 LIMK2 -0.39 -5.67 -0.3 3.09e-8 Colorectal cancer; CRC cis rs8177253 0.634 rs6798547 chr3:133448499 G/A cg11941060 chr3:133502564 NA -0.47 -7.64 -0.39 2.35e-13 Iron status biomarkers; CRC cis rs7927592 0.913 rs12285993 chr11:68302538 A/G cg16797656 chr11:68205561 LRP5 0.36 5.75 0.3 2.08e-8 Total body bone mineral density; CRC cis rs2032447 0.933 rs1540275 chr6:26036476 T/C cg03264133 chr6:25882463 NA -0.5 -6.81 -0.35 4.73e-11 Intelligence (multi-trait analysis); CRC cis rs981844 0.767 rs6857738 chr4:154689140 A/C cg10279832 chr4:154682576 RNF175 0.39 5.99 0.31 5.65e-9 Response to statins (LDL cholesterol change); CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg20376421 chr12:56546193 MYL6B 0.41 6.5 0.34 2.99e-10 Obesity-related traits; CRC cis rs929354 1.000 rs1182452 chr7:157053618 G/A cg17757837 chr7:157058334 UBE3C -0.88 -17.12 -0.69 1.98e-47 Body mass index; CRC cis rs919433 0.927 rs1429418 chr2:198158151 G/C cg10820045 chr2:198174542 NA -0.55 -9.37 -0.46 1.24e-18 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC cis rs7811142 0.830 rs7792959 chr7:99972403 C/T cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.02 14.45 0.62 5.37e-37 Platelet count; CRC cis rs17155006 0.664 rs378962 chr7:107739538 A/C cg05962710 chr7:107745446 LAMB4 -0.41 -7.25 -0.37 2.92e-12 Pneumococcal bacteremia; CRC cis rs172166 0.694 rs203877 chr6:28048624 T/C cg21251018 chr6:28226885 NKAPL 0.46 7.14 0.37 6.07e-12 Cardiac Troponin-T levels; CRC cis rs9902453 0.838 rs3110495 chr17:27978455 A/G cg26525008 chr17:28256777 EFCAB5;SSH2 -0.58 -8.97 -0.44 2.32e-17 Coffee consumption (cups per day); CRC cis rs1799949 1.000 rs16942 chr17:41244000 T/C cg05368731 chr17:41323189 NBR1 0.67 10.01 0.48 9.3e-21 Menopause (age at onset); CRC trans rs3118914 1.000 rs3116604 chr13:51114190 A/G cg09222023 chr3:138669322 C3orf72 0.35 5.96 0.31 6.48e-9 Height; CRC trans rs925098 0.577 rs2724470 chr4:17996046 A/G cg02732134 chr10:101732382 DNMBP 0.4 6.16 0.32 2.09e-9 Birth weight;Height; CRC cis rs2991971 0.967 rs7526665 chr1:46005832 G/T cg15605315 chr1:45957053 TESK2 0.43 6.95 0.36 2.01e-11 High light scatter reticulocyte count; CRC cis rs72634258 0.891 rs404381 chr1:8080745 C/T cg00042356 chr1:8021962 PARK7 0.49 6.08 0.32 3.26e-9 Inflammatory bowel disease; CRC cis rs514406 0.505 rs416968 chr1:53183513 A/G cg08859206 chr1:53392774 SCP2 -0.39 -6.17 -0.32 2.02e-9 Monocyte count; CRC cis rs7917772 0.503 rs1409310 chr10:104282265 T/C cg04362960 chr10:104952993 NT5C2 -0.42 -5.9 -0.31 8.92e-9 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC cis rs763014 0.932 rs2384975 chr16:651115 G/T cg09263875 chr16:632152 PIGQ 0.79 13.08 0.58 9.09e-32 Height; CRC cis rs2629540 0.889 rs10901815 chr10:126435598 G/A cg08799069 chr10:126477246 METTL10 -0.62 -8.62 -0.43 2.94e-16 Cocaine dependence; CRC cis rs561341 0.609 rs9906443 chr17:30185565 C/T cg00745463 chr17:30367425 LRRC37B 0.54 6.6 0.34 1.67e-10 Hip circumference adjusted for BMI; CRC cis rs34375054 0.573 rs12579211 chr12:125647752 C/T cg02766259 chr12:125626809 AACS -0.46 -6.35 -0.33 7.1e-10 Post bronchodilator FEV1/FVC ratio; CRC cis rs7224685 0.569 rs7215798 chr17:4007666 C/G cg11204139 chr17:3907470 NA -0.51 -6.42 -0.33 4.76e-10 Type 2 diabetes; CRC cis rs11168351 0.833 rs6580652 chr12:48447105 C/A cg24011408 chr12:48396354 COL2A1 -0.43 -6.31 -0.33 8.95e-10 Bipolar disorder and schizophrenia; CRC cis rs2290159 0.615 rs7610956 chr3:12677158 A/G cg23032965 chr3:12705835 RAF1 0.49 6.12 0.32 2.59e-9 Cholesterol, total; CRC cis rs4253772 0.637 rs6008357 chr22:46652104 T/G cg24881330 chr22:46731750 TRMU 0.57 6.73 0.35 7.54e-11 LDL cholesterol;Cholesterol, total; CRC trans rs1005277 0.579 rs1740747 chr10:38520465 G/A cg17830980 chr10:43048298 ZNF37B -0.57 -9.68 -0.47 1.16e-19 Extrinsic epigenetic age acceleration; CRC cis rs8060686 0.920 rs73591961 chr16:67801309 G/A cg07125278 chr16:67683757 RLTPR -0.63 -6.85 -0.35 3.56e-11 HDL cholesterol;Metabolic syndrome; CRC cis rs10504229 1.000 rs68076606 chr8:58191271 A/G cg22535103 chr8:58192502 C8orf71 -0.82 -12.27 -0.56 9.63e-29 Developmental language disorder (linguistic errors); CRC cis rs11711311 1.000 rs9811746 chr3:113515060 T/G cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.51 -6.98 -0.36 1.65e-11 IgG glycosylation; CRC cis rs875971 1.000 rs3735148 chr7:65971009 T/G cg00343986 chr7:65444356 GUSB 0.44 6.47 0.34 3.56e-10 Aortic root size; CRC cis rs2013441 0.866 rs10438824 chr17:20058510 C/T cg13482628 chr17:19912719 NA 0.4 5.73 0.3 2.28e-8 Obesity-related traits; CRC cis rs12479064 0.724 rs2305352 chr2:100015124 C/G cg14399236 chr2:99771627 LIPT1;TSGA10 -0.63 -7.98 -0.4 2.48e-14 Chronic sinus infection; CRC trans rs16838233 0.925 rs9426354 chr1:29763684 C/T cg12849791 chr3:38078307 NA -0.5 -6.08 -0.32 3.42e-9 Paclitaxel disposition in epithelial ovarian cancer; CRC trans rs2228479 0.717 rs1061647 chr16:89806063 G/C cg24644049 chr4:85504048 CDS1 0.9 7.39 0.38 1.19e-12 Skin colour saturation; CRC cis rs875971 0.862 rs2901152 chr7:65765004 G/A cg18876405 chr7:65276391 NA -0.53 -8.45 -0.42 9.32e-16 Aortic root size; CRC cis rs3617 0.573 rs12638968 chr3:52919447 T/A cg11645453 chr3:52864694 ITIH4 -0.38 -7.27 -0.37 2.7e-12 Red blood cell count;Autism spectrum disorder or schizophrenia; CRC cis rs2066819 1.000 rs41423244 chr12:56693520 A/C cg26714650 chr12:56694279 CS 1.4 11.48 0.53 6.96e-26 Psoriasis vulgaris; CRC cis rs7772486 0.875 rs9322043 chr6:146352690 A/G cg13319975 chr6:146136371 FBXO30 -0.39 -5.85 -0.31 1.16e-8 Lobe attachment (rater-scored or self-reported); CRC cis rs7259376 0.936 rs7259586 chr19:22537862 C/T cg02657401 chr19:22469223 NA -0.33 -7.32 -0.37 1.91e-12 Menopause (age at onset); CRC cis rs9491140 0.539 rs980656 chr6:124690303 A/G cg19267163 chr6:125004984 NKAIN2 0.44 5.93 0.31 7.78e-9 Neuroticism; CRC cis rs6964587 1.000 rs9690778 chr7:91735299 A/G cg17063962 chr7:91808500 NA 0.81 14.06 0.61 1.72e-35 Breast cancer; CRC cis rs1003719 0.762 rs3787780 chr21:38462614 A/G cg10648535 chr21:38446584 PIGP;TTC3 0.52 7.34 0.38 1.64e-12 Eye color traits; CRC cis rs12594515 1.000 rs8032361 chr15:45988553 T/C cg19682013 chr15:45996608 NA 0.32 6.7 0.35 9.09e-11 Waist circumference;Weight; CRC cis rs7809950 0.598 rs2283038 chr7:106835410 C/T cg23024343 chr7:107201750 COG5 -0.74 -10.01 -0.48 9.27e-21 Coronary artery disease; CRC cis rs2658782 0.547 rs3020054 chr11:93055556 C/T cg15737290 chr11:93063684 CCDC67 0.65 10.6 0.5 8.87e-23 Pulmonary function decline; CRC cis rs4975616 0.804 rs462608 chr5:1336626 T/A cg06550200 chr5:1325588 CLPTM1L -0.71 -11.19 -0.52 7.81e-25 Lung cancer; CRC trans rs10983614 1.000 rs7867776 chr9:120072627 A/G cg25405238 chr17:79254455 SLC38A10 0.42 5.99 0.31 5.39e-9 Survival in pancreatic cancer; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg02028540 chr16:67193883 TRADD;FBXL8 0.38 6.18 0.32 1.95e-9 Liver disease severity in Alagille syndrome; CRC cis rs2073300 0.609 rs6137950 chr20:23418722 T/A cg12062639 chr20:23401060 NAPB 0.81 7.48 0.38 6.75e-13 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs13108904 0.875 rs1732099 chr4:1282696 T/C cg24560729 chr4:1342394 KIAA1530 -0.34 -6.23 -0.32 1.43e-9 Obesity-related traits; CRC cis rs6772849 0.930 rs4467479 chr3:128369055 C/G cg08795948 chr3:128337044 NA 0.35 6.2 0.32 1.73e-9 Monocyte percentage of white cells;Monocyte count; CRC cis rs1129187 0.902 rs10948059 chr6:42928461 C/T cg10862848 chr6:42927986 GNMT -0.38 -9.01 -0.44 1.77e-17 Alzheimer's disease in APOE e4+ carriers; CRC cis rs4713118 0.824 rs9468223 chr6:27740666 C/T cg26587870 chr6:27730563 NA -0.46 -6.69 -0.35 9.65e-11 Parkinson's disease; CRC cis rs2398893 0.774 rs3909256 chr9:96889505 C/T cg14459158 chr9:96720562 NA -0.45 -6.38 -0.33 5.9e-10 Waist-hip ratio;Waist-to-hip ratio adjusted for body mass index; CRC cis rs7772486 0.754 rs6922507 chr6:146250155 A/T cg23711669 chr6:146136114 FBXO30 -0.72 -12.62 -0.57 4.76e-30 Lobe attachment (rater-scored or self-reported); CRC cis rs13082711 0.911 rs923940 chr3:27459341 C/G cg02860705 chr3:27208620 NA 0.58 8.3 0.42 2.68e-15 Systolic blood pressure;Diastolic blood pressure;Blood pressure; CRC cis rs950169 0.887 rs220333 chr15:85091133 C/T cg17507749 chr15:85114479 UBE2QP1 0.74 11.28 0.53 3.53e-25 Schizophrenia; CRC cis rs12142240 0.692 rs7529674 chr1:46818508 T/C cg00530320 chr1:46809349 NSUN4 0.58 7.93 0.4 3.43e-14 Menopause (age at onset); CRC cis rs853679 0.538 rs13199081 chr6:28331834 T/C cg21251018 chr6:28226885 NKAPL 0.43 6.15 0.32 2.23e-9 Depression; CRC cis rs6964587 1.000 rs36021614 chr7:91717490 C/G cg17063962 chr7:91808500 NA 0.77 12.78 0.58 1.2e-30 Breast cancer; CRC cis rs9787249 0.957 rs12086750 chr1:40210468 G/C cg24920358 chr1:40204285 PPIE 0.56 8.53 0.43 5.37e-16 Blood protein levels; CRC cis rs2073499 1.000 rs1989839 chr3:50378946 A/G cg09545109 chr3:50388910 TUSC4;CYB561D2 0.59 6.3 0.33 9.68e-10 Schizophrenia; CRC cis rs6500602 0.592 rs4785966 chr16:4518754 C/T cg14951292 chr16:4525986 HMOX2;NMRAL1 -0.54 -7.59 -0.39 3.29e-13 Schizophrenia; CRC cis rs7098414 0.511 rs10749592 chr10:82150891 C/T cg00277334 chr10:82204260 NA -0.45 -7.3 -0.37 2.13e-12 Post bronchodilator FEV1; CRC cis rs6502050 0.698 rs36043222 chr17:80117822 G/T cg13198984 chr17:80129470 CCDC57 0.46 8.24 0.41 4.11e-15 Life satisfaction; CRC cis rs2836974 0.831 rs2836964 chr21:40631006 T/C cg17971929 chr21:40555470 PSMG1 0.83 11.92 0.55 1.73e-27 Cognitive function; CRC trans rs72862334 0.529 rs72863715 chr2:146656925 C/T cg02985445 chr7:97908505 NA 0.39 6.23 0.32 1.45e-9 Coronary artery disease; CRC cis rs7666738 0.830 rs13129503 chr4:98987892 T/C cg05340658 chr4:99064831 C4orf37 0.6 9.41 0.46 8.57e-19 Colonoscopy-negative controls vs population controls; CRC cis rs2204008 0.628 rs10876106 chr12:37990767 A/G cg13010199 chr12:38710504 ALG10B 0.47 6.23 0.32 1.4e-9 Bladder cancer; CRC cis rs17270561 0.636 rs1165216 chr6:25797971 G/A cg17691542 chr6:26056736 HIST1H1C 0.52 7.09 0.36 8.45e-12 Iron status biomarkers; CRC cis rs11785400 1.000 rs4266629 chr8:143736635 A/G cg10596483 chr8:143751796 JRK 0.48 6.76 0.35 6.35e-11 Schizophrenia; CRC cis rs6952808 0.729 rs35797753 chr7:1954914 G/A cg21782813 chr7:2030301 MAD1L1 0.46 7.83 0.4 6.73e-14 Bipolar disorder and schizophrenia; CRC cis rs9314323 0.964 rs3808579 chr8:26250682 C/T cg13160058 chr8:26243215 BNIP3L -0.47 -8.22 -0.41 4.66e-15 Red cell distribution width; CRC cis rs17270561 0.636 rs9393656 chr6:25722059 A/C cg16482183 chr6:26056742 HIST1H1C 0.73 9.45 0.46 6.59e-19 Iron status biomarkers; CRC cis rs1552244 1.000 rs6782602 chr3:10116541 G/T cg16606324 chr3:10149918 C3orf24 0.7 9.66 0.47 1.31e-19 Alzheimer's disease; CRC cis rs4731207 0.698 rs34618371 chr7:124496170 C/T cg23710748 chr7:124431027 NA -0.38 -6.1 -0.32 2.96e-9 Cutaneous malignant melanoma; CRC cis rs12701220 0.655 rs6463317 chr7:1159243 G/A cg02733842 chr7:1102375 C7orf50 -0.61 -8.02 -0.4 1.89e-14 Bronchopulmonary dysplasia; CRC trans rs1908814 0.516 rs58869268 chr8:11797095 G/C cg08975724 chr8:8085496 FLJ10661 0.41 6.16 0.32 2.18e-9 Neuroticism; CRC cis rs10504229 0.728 rs72650858 chr8:58152832 G/A cg05313129 chr8:58192883 C8orf71 -0.47 -6.18 -0.32 1.94e-9 Developmental language disorder (linguistic errors); CRC cis rs6933660 0.800 rs9383900 chr6:151782816 A/C cg14416726 chr6:151773293 C6orf211;RMND1 -0.65 -10.07 -0.49 5.54e-21 Menarche (age at onset); CRC trans rs1814175 0.619 rs10769623 chr11:49865926 C/T cg21153622 chr11:89784906 NA -0.39 -6.17 -0.32 2.04e-9 Height; CRC cis rs1215050 0.791 rs1585088 chr4:98675071 C/A cg05340658 chr4:99064831 C4orf37 -0.47 -7.02 -0.36 1.29e-11 Waist-to-hip ratio adjusted for body mass index; CRC cis rs7208859 0.614 rs216412 chr17:28903394 A/G cg01831904 chr17:28903510 LRRC37B2 0.5 6.2 0.32 1.74e-9 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs9814567 0.806 rs4074522 chr3:134325626 A/G cg06109529 chr3:134205091 CEP63;ANAPC13 0.68 10.07 0.49 5.78e-21 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs3096299 0.719 rs2911262 chr16:89515041 C/T cg08392591 chr16:89556376 ANKRD11 0.41 5.6 0.3 4.44e-8 Multiple myeloma (IgH translocation); CRC cis rs9611519 0.894 rs8136923 chr22:41470522 G/A cg06634786 chr22:41940651 POLR3H -0.44 -5.7 -0.3 2.66e-8 Neuroticism; CRC cis rs4409675 0.576 rs10794507 chr1:28216072 T/C cg11176159 chr1:28213800 NA 0.3 5.86 0.31 1.13e-8 Corneal astigmatism; CRC cis rs6540559 0.611 rs926347 chr1:209965193 T/C cg23283495 chr1:209979779 IRF6 0.48 6.8 0.35 4.82e-11 Cleft lip with or without cleft palate; CRC cis rs6496044 0.568 rs3743321 chr15:86064968 A/G cg17133734 chr15:86042851 AKAP13 0.41 6.78 0.35 5.67e-11 Interstitial lung disease; CRC cis rs9488822 0.636 rs6937104 chr6:116375302 A/G cg18764771 chr6:116381957 FRK 0.26 7.46 0.38 7.62e-13 Cholesterol, total;LDL cholesterol; CRC cis rs9359856 0.510 rs6454775 chr6:90465000 A/T cg13799429 chr6:90582589 CASP8AP2 0.76 10.0 0.48 9.56e-21 Bipolar disorder; CRC cis rs9814567 1.000 rs7427492 chr3:134261654 C/T cg06541857 chr3:134203789 ANAPC13;CEP63 -0.41 -6.27 -0.33 1.16e-9 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs593982 0.925 rs3953806 chr11:65505153 C/T cg08755490 chr11:65554678 OVOL1 -1.08 -12.43 -0.57 2.49e-29 Atopic dermatitis; CRC cis rs394563 0.726 rs6906384 chr6:149664540 G/A cg07828024 chr6:149772892 ZC3H12D 0.49 9.24 0.45 3.25e-18 Dupuytren's disease; CRC cis rs4713118 0.587 rs9393899 chr6:28133528 G/C cg03623178 chr6:28175578 NA 0.98 12.66 0.57 3.31e-30 Parkinson's disease; CRC cis rs7192380 0.893 rs12924052 chr16:69777246 T/C cg00738113 chr16:70207722 CLEC18C 0.34 5.99 0.31 5.61e-9 Sjögren's syndrome; CRC cis rs765787 0.530 rs4775835 chr15:45537553 T/C cg24006582 chr15:45444508 DUOX1 -0.57 -8.63 -0.43 2.62e-16 Uric acid levels; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg12741539 chr12:42719903 PPHLN1;ZCRB1 0.43 6.0 0.31 5.18e-9 Response to antipsychotic treatment; CRC cis rs77633900 0.614 rs157757 chr15:76855927 G/C cg21673338 chr15:77095150 SCAPER -0.71 -6.93 -0.36 2.28e-11 Non-glioblastoma glioma;Glioma; CRC trans rs1973993 0.507 rs2759670 chr1:97002864 A/G cg10631902 chr5:14652156 NA 0.5 9.2 0.45 4.34e-18 Weight; CRC cis rs57221529 0.713 rs12521091 chr5:590710 G/T cg14541582 chr5:601475 NA -0.33 -6.32 -0.33 8.55e-10 Lung disease severity in cystic fibrosis; CRC cis rs4970988 0.501 rs11204713 chr1:150694623 T/A cg15448220 chr1:150897856 SETDB1 0.45 6.4 0.33 5.25e-10 Urate levels; CRC cis rs4889855 0.578 rs7216808 chr17:78484187 A/G cg16591659 chr17:78472290 NA -0.6 -7.46 -0.38 7.96e-13 Fractional excretion of uric acid; CRC cis rs4144743 1.000 rs4541130 chr17:45321037 G/A cg18085866 chr17:45331354 ITGB3 -0.59 -8.02 -0.4 1.86e-14 Body mass index; CRC trans rs7580658 0.614 rs7585198 chr2:127962635 C/T cg11590700 chr3:169381241 MECOM -0.41 -6.11 -0.32 2.75e-9 Protein C levels; CRC cis rs7618915 0.547 rs13085331 chr3:52627486 G/C cg07507251 chr3:52567010 NT5DC2 0.42 5.98 0.31 5.82e-9 Bipolar disorder; CRC cis rs344364 0.529 rs186941 chr16:1930088 T/C cg26897989 chr16:1907736 C16orf73 0.49 5.87 0.31 1.04e-8 Glomerular filtration rate in chronic kidney disease; CRC cis rs704795 0.836 rs1083865 chr2:27620827 A/G cg17158414 chr2:27665306 KRTCAP3 -0.29 -6.23 -0.32 1.45e-9 Menopause (age at onset); CRC cis rs7085104 0.700 rs7096183 chr10:104609466 T/C cg04362960 chr10:104952993 NT5C2 0.59 8.66 0.43 2.22e-16 Immature fraction of reticulocytes;Schizophrenia; CRC trans rs6833159 0.527 rs10939231 chr4:28829372 A/T cg25420398 chr3:133968920 RYK -0.41 -6.05 -0.32 3.97e-9 Underweight status; CRC cis rs6121246 0.529 rs6060171 chr20:30183269 C/T cg13852791 chr20:30311386 BCL2L1 0.59 8.11 0.41 1.01e-14 Mean corpuscular hemoglobin; CRC cis rs4319547 0.915 rs10734924 chr12:123018894 T/G cg23029597 chr12:123009494 RSRC2 -0.65 -8.08 -0.41 1.2e-14 Body mass index; CRC cis rs7610312 0.681 rs6445972 chr3:58321707 C/T cg06643156 chr3:58380774 PXK -0.38 -5.65 -0.3 3.53e-8 Red blood cell count; CRC cis rs2279817 0.863 rs2270976 chr1:18023690 A/G cg21791023 chr1:18019539 ARHGEF10L 0.51 6.16 0.32 2.09e-9 Neuroticism; CRC cis rs1670533 0.615 rs59985183 chr4:1087171 G/T cg27284194 chr4:1044797 NA 0.45 6.09 0.32 3.14e-9 Recombination rate (females); CRC cis rs28386778 0.863 rs2597633 chr17:61872871 T/C cg06601766 chr17:61851465 DDX42;CCDC47 0.44 5.96 0.31 6.5e-9 Prudent dietary pattern; CRC cis rs2228479 0.717 rs1007932 chr16:89838541 C/T cg04013166 chr16:89971882 TCF25 0.6 5.93 0.31 7.53e-9 Skin colour saturation; CRC cis rs17401966 1.000 rs12118323 chr1:10469641 A/G cg19773385 chr1:10388646 KIF1B -0.67 -10.4 -0.5 4.25e-22 Hepatocellular carcinoma; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg06272495 chr22:17652825 NA 0.42 6.34 0.33 7.71e-10 Liver disease severity in Alagille syndrome; CRC cis rs6424115 0.830 rs2502995 chr1:24199290 T/C cg10978503 chr1:24200527 CNR2 0.62 11.3 0.53 3.08e-25 Immature fraction of reticulocytes; CRC cis rs1943345 0.642 rs11233500 chr11:82881407 C/T cg07047830 chr11:82868014 PCF11 -0.44 -6.39 -0.33 5.53e-10 Obesity-related traits; CRC trans rs1814175 0.817 rs4881658 chr11:49941123 G/A cg11707556 chr5:10655725 ANKRD33B -0.43 -7.99 -0.4 2.27e-14 Height; CRC cis rs61008539 0.893 rs11765528 chr7:861952 C/T cg15782153 chr7:917662 C7orf20 0.5 8.03 0.4 1.74e-14 Perceived unattractiveness to mosquitoes; CRC cis rs7258465 1.000 rs271621 chr19:18631332 C/A cg06462663 chr19:18546047 ISYNA1 0.5 7.63 0.39 2.48e-13 Breast cancer; CRC cis rs9902453 0.845 rs2628165 chr17:28121166 A/G cg26525008 chr17:28256777 EFCAB5;SSH2 0.57 8.67 0.43 1.99e-16 Coffee consumption (cups per day); CRC cis rs769267 0.899 rs3934667 chr19:19431423 T/G cg03709012 chr19:19516395 GATAD2A -0.67 -10.33 -0.49 7.67e-22 Tonsillectomy; CRC cis rs6951245 1.000 rs78308415 chr7:1072634 G/A cg08132940 chr7:1081526 C7orf50 -0.54 -5.64 -0.3 3.76e-8 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs372883 0.613 rs1153290 chr21:30687404 G/T cg24692254 chr21:30365293 RNF160 -0.57 -8.7 -0.43 1.57e-16 Pancreatic cancer; CRC cis rs3809566 0.963 rs12148057 chr15:63331509 A/T cg05507819 chr15:63340323 TPM1 0.45 6.83 0.35 4.18e-11 Platelet count; CRC cis rs4844614 1.000 rs6661764 chr1:207808385 C/G cg17822947 chr1:207842917 CR1L 0.33 5.89 0.31 9.49e-9 LDL cholesterol; CRC cis rs3806843 0.735 rs6849 chr5:140086191 G/T cg19875535 chr5:140030758 IK -0.62 -10.38 -0.5 5.13e-22 Depressive symptoms (multi-trait analysis); CRC cis rs4727963 0.765 rs1464877 chr7:122734266 G/A cg03640110 chr7:122635026 TAS2R16 0.35 6.33 0.33 8.19e-10 Adverse response to chemotherapy (neutropenia/leucopenia) (docetaxel); CRC cis rs7811142 0.830 rs705866 chr7:99965285 T/C cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.55 6.66 0.34 1.12e-10 Platelet count; CRC cis rs7208859 0.623 rs11657990 chr17:29124200 C/T cg01831904 chr17:28903510 LRRC37B2 -0.63 -6.49 -0.34 3.2e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs1113500 0.933 rs10785834 chr1:108639101 A/C cg06207961 chr1:108661230 NA 0.39 5.78 0.3 1.72e-8 Growth-regulated protein alpha levels; CRC cis rs11250464 1.000 rs11250464 chr10:1406364 A/G cg26394196 chr10:1453818 ADARB2 -0.31 -5.65 -0.3 3.45e-8 Radiation response; CRC cis rs1639906 0.965 rs1637742 chr7:2236432 G/A cg19897017 chr7:2163380 MAD1L1 0.41 6.23 0.32 1.45e-9 Colonoscopy-negative controls vs population controls; CRC cis rs611744 0.647 rs12675265 chr8:109268805 C/T cg21045802 chr8:109455806 TTC35 0.42 6.63 0.34 1.34e-10 Dupuytren's disease; CRC cis rs10504229 0.683 rs17802743 chr8:58105897 C/T cg02725872 chr8:58115012 NA -0.58 -8.18 -0.41 6.44e-15 Developmental language disorder (linguistic errors); CRC cis rs28386778 0.897 rs2584642 chr17:61942427 T/C cg23090583 chr17:61904693 PSMC5;FTSJ3 1.03 20.22 0.74 1.2e-59 Prudent dietary pattern; CRC cis rs7615952 0.576 rs6780025 chr3:125815624 A/C cg18479299 chr3:125709523 NA -0.56 -6.64 -0.34 1.3e-10 Blood pressure (smoking interaction); CRC cis rs10256972 0.681 rs12702016 chr7:1129392 C/T cg07092213 chr7:1199455 ZFAND2A -0.4 -5.67 -0.3 3.08e-8 Longevity;Endometriosis; CRC cis rs11148252 0.508 rs6561671 chr13:53182314 G/A cg02158880 chr13:53174818 NA 0.59 9.46 0.46 6.12e-19 Lewy body disease; CRC cis rs9291683 0.517 rs11736479 chr4:10017387 G/C cg11266682 chr4:10021025 SLC2A9 0.54 11.57 0.54 3.2e-26 Bone mineral density; CRC cis rs6665290 0.835 rs7549586 chr1:227214566 A/G cg10327440 chr1:227177885 CDC42BPA -0.97 -18.53 -0.71 5.16e-53 Myeloid white cell count; CRC trans rs66573146 1.000 rs67067921 chr4:6984341 A/T cg07817883 chr1:32538562 TMEM39B 1.51 13.37 0.59 7.39e-33 Granulocyte percentage of myeloid white cells; CRC cis rs2032447 0.898 rs807205 chr6:26075035 C/G cg04800585 chr6:26043546 HIST1H2BB 0.52 7.72 0.39 1.37e-13 Intelligence (multi-trait analysis); CRC cis rs611744 0.647 rs628206 chr8:109247873 A/G cg21045802 chr8:109455806 TTC35 0.42 6.68 0.35 1.05e-10 Dupuytren's disease; CRC cis rs11098499 0.866 rs7677068 chr4:120291704 C/T cg09307838 chr4:120376055 NA 0.68 10.53 0.5 1.51e-22 Corneal astigmatism; CRC cis rs881375 1.000 rs10117059 chr9:123653477 G/C cg14255062 chr9:123606675 PSMD5;LOC253039 0.43 6.22 0.32 1.51e-9 Rheumatoid arthritis; CRC cis rs9487051 0.768 rs1766814 chr6:109526696 G/A cg01475377 chr6:109611718 NA -0.33 -5.72 -0.3 2.4e-8 Reticulocyte fraction of red cells; CRC cis rs7772486 0.846 rs9373482 chr6:146363123 A/C cg23711669 chr6:146136114 FBXO30 0.68 11.87 0.55 2.69e-27 Lobe attachment (rater-scored or self-reported); CRC cis rs889312 0.500 rs832580 chr5:56172646 T/C cg12311346 chr5:56204834 C5orf35 -0.46 -6.97 -0.36 1.74e-11 Breast cancer;Breast cancer (early onset); CRC cis rs1448094 0.511 rs58742237 chr12:86166444 C/T cg02569458 chr12:86230093 RASSF9 0.46 7.6 0.39 3.1400000000000003e-13 Major depressive disorder; CRC cis rs1552244 0.935 rs7621551 chr3:10114205 C/T cg18598329 chr3:10140678 FANCD2;C3orf24 -0.87 -11.82 -0.55 4.24e-27 Alzheimer's disease; CRC cis rs7666738 0.830 rs4472144 chr4:98956494 G/A cg05340658 chr4:99064831 C4orf37 0.58 8.95 0.44 2.7e-17 Colonoscopy-negative controls vs population controls; CRC cis rs2692947 0.630 rs1168966 chr2:96798510 G/A cg23100626 chr2:96804247 ASTL 0.27 7.32 0.37 1.93e-12 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; CRC cis rs16852403 0.904 rs6703721 chr1:178037791 C/T cg00404053 chr1:178313656 RASAL2 0.49 6.18 0.32 1.91e-9 Childhood ear infection; CRC cis rs4713118 0.824 rs9468225 chr6:27745719 T/G cg03623178 chr6:28175578 NA 0.72 9.54 0.47 3.37e-19 Parkinson's disease; CRC cis rs9858542 0.953 rs7623659 chr3:49414791 C/T cg03060546 chr3:49711283 APEH -0.48 -6.85 -0.35 3.71e-11 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs10979 1.000 rs9403507 chr6:143887821 C/G cg25407410 chr6:143891975 LOC285740 0.52 7.79 0.39 8.75e-14 Hypospadias; CRC cis rs6121246 0.559 rs6087779 chr20:30370566 T/C cg13852791 chr20:30311386 BCL2L1 0.78 15.32 0.65 2.24e-40 Mean corpuscular hemoglobin; CRC cis rs11711311 1.000 rs9865965 chr3:113450495 C/T cg15478005 chr3:113465772 ATP6V1A;NAA50 0.45 6.15 0.32 2.19e-9 IgG glycosylation; CRC cis rs7944584 0.632 rs7116451 chr11:47322327 G/A cg20307385 chr11:47447363 PSMC3 0.65 8.76 0.43 1.07e-16 Fasting blood glucose;Fasting blood glucose (BMI interaction); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg06837731 chr10:101945906 ERLIN1 0.46 6.74 0.35 7.09e-11 Intelligence (multi-trait analysis); CRC cis rs1062746 0.771 rs10514621 chr16:87369578 G/T cg02258303 chr16:87377426 FBXO31 -0.64 -10.6 -0.5 8.95e-23 Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 2 peripheral neuropathy); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg12738864 chr3:40566248 ZNF621 0.42 6.01 0.31 4.8e-9 Response to antipsychotic treatment; CRC cis rs1691799 0.867 rs1168297 chr12:66735644 T/C cg16791601 chr12:66731901 HELB -0.67 -11.29 -0.53 3.27e-25 White blood cell count (basophil); CRC cis rs28386778 0.897 rs2665832 chr17:61912261 C/T cg06873352 chr17:61820015 STRADA 0.77 14.57 0.63 1.9e-37 Prudent dietary pattern; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg11039072 chr15:35280907 ZNF770 0.45 6.29 0.33 9.98e-10 Response to antipsychotic treatment; CRC trans rs57590327 0.503 rs2372906 chr3:81504673 G/A cg23387109 chr10:94051229 MARCH5;CPEB3 -0.44 -5.97 -0.31 6.24e-9 Extraversion; CRC cis rs4665809 0.589 rs4665842 chr2:26448954 A/G cg22920501 chr2:26401640 FAM59B -0.83 -11.91 -0.55 1.9e-27 Gut microbiome composition (summer); CRC cis rs1691799 0.899 rs1168358 chr12:66748664 A/G cg16791601 chr12:66731901 HELB -0.69 -11.69 -0.54 1.23e-26 White blood cell count (basophil); CRC cis rs951366 0.528 rs1172198 chr1:205662718 C/T cg26354017 chr1:205819088 PM20D1 0.65 9.07 0.45 1.1e-17 Menarche (age at onset); CRC cis rs6735179 0.837 rs6548058 chr2:1775108 T/A cg26137290 chr2:1776737 NA -0.46 -6.1 -0.32 2.98e-9 Response to antipsychotic treatment; CRC trans rs2797160 1.000 rs1739363 chr6:126020980 G/A cg05039488 chr6:79577232 IRAK1BP1 0.5 7.47 0.38 7.24e-13 Endometrial cancer; CRC trans rs8050260 0.500 rs4783650 chr16:68558528 T/C cg04657470 chr2:198365150 HSPE1;HSPD1 -0.55 -6.05 -0.32 3.94e-9 Plateletcrit; CRC cis rs72634258 1.000 rs72634258 chr1:8150638 T/C cg26816564 chr1:7831052 VAMP3 0.6 6.33 0.33 8.17e-10 Inflammatory bowel disease; CRC cis rs9325144 0.534 rs1843887 chr12:38692380 T/C cg26384229 chr12:38710491 ALG10B 0.54 8.16 0.41 7.02e-15 Morning vs. evening chronotype; CRC cis rs853679 0.517 rs1904840 chr6:28108232 C/T cg02683197 chr6:28174875 NA 0.87 10.73 0.51 3.25e-23 Depression; CRC cis rs60871478 0.636 rs4276575 chr7:900035 C/T cg13798912 chr7:905769 UNC84A -0.58 -6.69 -0.35 9.33e-11 Cerebrospinal P-tau181p levels; CRC cis rs75920871 0.528 rs7930264 chr11:116870766 G/A cg20608306 chr11:116969690 SIK3 -0.34 -6.5 -0.34 2.97e-10 Subjective well-being; CRC cis rs4665809 1.000 rs1371553 chr2:26262948 G/A cg04944784 chr2:26401820 FAM59B -0.6 -7.73 -0.39 1.31e-13 Gut microbiome composition (summer); CRC cis rs9649213 1.000 rs9649213 chr7:98021211 A/G cg09267113 chr7:98030324 BAIAP2L1 -0.55 -7.68 -0.39 1.87e-13 Prostate cancer (SNP x SNP interaction); CRC cis rs7586879 0.616 rs10206196 chr2:25137323 T/C cg22495460 chr2:25135724 ADCY3 -0.87 -16.52 -0.67 4.65e-45 Body mass index; CRC cis rs9435341 0.762 rs2878349 chr1:107549245 G/A cg14828511 chr1:107599125 PRMT6 0.45 6.21 0.32 1.58e-9 Facial morphology (factor 21, depth of nasal alae); CRC cis rs9486719 0.948 rs12203657 chr6:96883285 G/A cg06623918 chr6:96969491 KIAA0776 -0.81 -9.51 -0.46 4.17e-19 Migraine;Coronary artery disease; CRC cis rs1862618 0.853 rs252887 chr5:56166188 A/G cg18230493 chr5:56204884 C5orf35 -0.74 -9.2 -0.45 4.23e-18 Initial pursuit acceleration; CRC cis rs853679 0.527 rs213228 chr6:28331252 A/C cg03623178 chr6:28175578 NA 0.42 5.76 0.3 1.95e-8 Depression; CRC cis rs7568458 0.811 rs3755014 chr2:85764006 C/T cg02493740 chr2:85810744 VAMP5 -0.4 -6.28 -0.33 1.09e-9 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); CRC cis rs2380220 0.606 rs4559095 chr6:95994154 A/C cg04719120 chr6:96025338 MANEA 0.52 6.44 0.33 4.13e-10 Behavioural disinhibition (generation interaction); CRC cis rs910316 0.737 rs175048 chr14:75479894 A/T cg11812906 chr14:75593930 NEK9 -0.55 -8.36 -0.42 1.85e-15 Height; CRC trans rs13046373 0.905 rs4816372 chr21:32077414 A/T cg22132876 chr20:62189343 NA -0.37 -6.05 -0.32 3.94e-9 HDL cholesterol; CRC cis rs11122272 0.735 rs2572263 chr1:231509408 C/T cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.54 -8.11 -0.41 1.04e-14 Hemoglobin concentration; CRC cis rs9916302 0.904 rs13341996 chr17:37536862 C/T cg00129232 chr17:37814104 STARD3 0.53 7.92 0.4 3.58e-14 Glomerular filtration rate (creatinine); CRC cis rs832540 0.902 rs194059 chr5:56197416 G/A cg12311346 chr5:56204834 C5orf35 -0.47 -6.92 -0.36 2.3e-11 Coronary artery disease; CRC cis rs9814567 0.896 rs10935123 chr3:134345327 C/G cg06109529 chr3:134205091 CEP63;ANAPC13 -0.67 -9.59 -0.47 2.35e-19 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs1552244 1.000 rs3846177 chr3:10068572 G/T cg10729496 chr3:10149963 C3orf24 0.5 6.71 0.35 8.29e-11 Alzheimer's disease; CRC cis rs4665809 0.590 rs4665837 chr2:26434022 C/A cg08067268 chr2:26466485 HADHB;HADHA -0.68 -8.61 -0.43 2.97e-16 Gut microbiome composition (summer); CRC cis rs919433 0.963 rs4850428 chr2:198169772 G/A cg03934865 chr2:198174659 NA -0.46 -7.25 -0.37 2.93e-12 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC trans rs8124695 0.764 rs61526616 chr20:39012631 G/A cg15699267 chr20:61809557 MIR124-3 -0.54 -6.08 -0.32 3.33e-9 Dupuytren's disease; CRC cis rs2806561 0.929 rs6694445 chr1:23540428 A/G cg19743168 chr1:23544995 NA 0.36 5.61 0.3 4.39e-8 Height; CRC cis rs780096 0.506 rs1647286 chr2:27714517 A/T cg21248554 chr2:27665150 KRTCAP3 -0.36 -8.41 -0.42 1.24e-15 Total body bone mineral density; CRC trans rs11722228 0.549 rs73212863 chr4:10104173 C/T cg26043149 chr18:55253948 FECH 1.12 17.14 0.69 1.66e-47 Gout;Urate levels;Serum uric acid levels; CRC cis rs7618915 0.501 rs2079929 chr3:52765646 C/T cg08222913 chr3:52553049 STAB1 -0.33 -6.12 -0.32 2.72e-9 Bipolar disorder; CRC cis rs736801 0.808 rs2522057 chr5:131801947 C/G cg02033258 chr5:131593261 PDLIM4 0.34 6.08 0.32 3.4e-9 Breast cancer;Mosquito bite size; CRC cis rs6788895 0.661 rs16862837 chr3:150469858 A/C cg09723797 chr3:150481914 SIAH2 -0.65 -5.61 -0.3 4.36e-8 Breast cancer; CRC cis rs9549367 0.826 rs9549713 chr13:113905308 G/T cg00898013 chr13:113819073 PROZ -0.46 -6.47 -0.34 3.56e-10 Platelet distribution width; CRC cis rs7208859 0.573 rs60724269 chr17:29113273 G/T cg13385521 chr17:29058706 SUZ12P 0.74 8.44 0.42 9.97e-16 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs17376456 0.825 rs17314797 chr5:93234845 T/A cg25358565 chr5:93447407 FAM172A 1.06 10.61 0.5 8.48e-23 Diabetic retinopathy; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg20648385 chr11:72525603 ATG16L2 0.36 6.12 0.32 2.67e-9 Liver disease severity in Alagille syndrome; CRC cis rs7615952 0.611 rs7632305 chr3:125634767 C/T cg05084668 chr3:125655381 ALG1L -0.84 -10.45 -0.5 3.01e-22 Blood pressure (smoking interaction); CRC cis rs7666738 0.830 rs4699597 chr4:99019031 G/A cg05340658 chr4:99064831 C4orf37 0.61 9.51 0.46 4.05e-19 Colonoscopy-negative controls vs population controls; CRC cis rs4523957 0.855 rs12601834 chr17:2112431 C/T cg16513277 chr17:2031491 SMG6 -0.52 -8.62 -0.43 2.82e-16 Autism spectrum disorder or schizophrenia;Schizophrenia; CRC cis rs875971 0.545 rs6460281 chr7:65681115 A/C cg05627663 chr7:65219948 SNORA22;CCT6P1 0.64 8.34 0.42 2.12e-15 Aortic root size; CRC cis rs13191362 0.507 rs6936804 chr6:163069424 A/T cg21926612 chr6:163149169 PACRG;PARK2 -0.61 -9.4 -0.46 9.84e-19 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs1448094 0.512 rs12305828 chr12:86249153 C/G cg00310523 chr12:86230176 RASSF9 0.35 5.93 0.31 7.63e-9 Major depressive disorder; CRC trans rs9858542 1.000 rs34762726 chr3:49689210 G/A cg21665057 chr3:196295764 WDR53;FBXO45 -0.67 -8.78 -0.44 9e-17 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs9814567 1.000 rs1814336 chr3:134200823 G/C cg06109529 chr3:134205091 CEP63;ANAPC13 -0.83 -12.67 -0.57 3.13e-30 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs11148252 0.595 rs4884522 chr13:53053768 C/A cg00495681 chr13:53174319 NA 0.84 15.56 0.65 2.72e-41 Lewy body disease; CRC cis rs9372498 0.505 rs62424202 chr6:118851027 T/C cg18833306 chr6:118973337 C6orf204 0.46 5.99 0.31 5.55e-9 Diastolic blood pressure; CRC cis rs853679 0.546 rs200995 chr6:27813694 C/T cg08798685 chr6:27730294 NA 0.62 5.95 0.31 7.04e-9 Depression; CRC cis rs758324 0.947 rs683749 chr5:131283376 C/T cg06307176 chr5:131281290 NA -0.42 -6.22 -0.32 1.54e-9 Alzheimer's disease in APOE e4- carriers; CRC trans rs1814175 0.645 rs28447324 chr11:50046629 C/A cg03929089 chr4:120376271 NA -0.89 -15.95 -0.66 7.68e-43 Height; CRC cis rs634534 0.622 rs501353 chr11:65739549 T/G cg17985854 chr11:65770987 BANF1;EIF1AD 0.42 6.93 0.36 2.19e-11 Sum eosinophil basophil counts;Eosinophil counts; CRC cis rs10979 0.964 rs35205240 chr6:143898676 T/C cg25407410 chr6:143891975 LOC285740 -0.85 -13.66 -0.6 5.96e-34 Hypospadias; CRC trans rs7826238 0.509 rs2948288 chr8:8115304 A/G cg16141378 chr3:129829833 LOC729375 -0.57 -8.84 -0.44 5.73e-17 Systolic blood pressure; CRC cis rs1005277 0.505 rs7099777 chr10:38183569 A/C cg25427524 chr10:38739819 LOC399744 0.74 13.04 0.58 1.23e-31 Extrinsic epigenetic age acceleration; CRC cis rs13108904 0.840 rs13149790 chr4:1262239 A/G cg00684032 chr4:1343700 KIAA1530 0.46 6.86 0.35 3.42e-11 Obesity-related traits; CRC cis rs3733585 0.699 rs6844787 chr4:9959233 A/G cg00071950 chr4:10020882 SLC2A9 -0.54 -9.65 -0.47 1.42e-19 Cleft plate (environmental tobacco smoke interaction); CRC cis rs9914988 0.943 rs4795467 chr17:27180784 C/T cg16670446 chr17:27188758 MIR451;MIR144 0.49 7.03 0.36 1.18e-11 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs8072100 0.745 rs7214410 chr17:45422628 A/G cg08085267 chr17:45401833 C17orf57 -0.69 -11.84 -0.55 3.61e-27 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs300703 0.654 rs435733 chr2:121222 A/G cg21211680 chr2:198530 NA -0.99 -11.71 -0.54 1.01e-26 Blood protein levels; CRC cis rs10751667 0.643 rs6597969 chr11:928843 C/T ch.11.42038R chr11:967971 AP2A2 0.6 10.22 0.49 1.74e-21 Alzheimer's disease (late onset); CRC cis rs8141529 0.748 rs6005936 chr22:29289250 T/C cg02153584 chr22:29168773 CCDC117 0.47 6.73 0.35 7.62e-11 Lymphocyte counts; CRC cis rs6679356 0.789 rs6662198 chr1:67806207 T/C cg24364144 chr1:67875067 SERBP1 0.41 6.19 0.32 1.79e-9 Primary biliary cholangitis; CRC cis rs736408 0.609 rs62255396 chr3:52782839 C/T cg07507251 chr3:52567010 NT5DC2 0.41 5.84 0.31 1.27e-8 Bipolar disorder; CRC cis rs2120019 0.938 rs2289582 chr15:75310394 T/C cg09165964 chr15:75287851 SCAMP5 -0.87 -13.39 -0.59 6.11e-33 Blood trace element (Zn levels); CRC cis rs2625529 0.652 rs8028115 chr15:72339503 C/T cg16672083 chr15:72433130 SENP8 0.46 6.92 0.36 2.3e-11 Red blood cell count; CRC cis rs7264396 0.622 rs3787165 chr20:34228946 T/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.59 -9.72 -0.47 8.68e-20 Total cholesterol levels; CRC cis rs6964587 1.000 rs61244255 chr7:91751662 C/T cg17063962 chr7:91808500 NA 0.81 13.12 0.59 6.39e-32 Breast cancer; CRC cis rs9926296 0.512 rs11076626 chr16:89865103 T/A cg21285383 chr16:89894308 SPIRE2 0.38 6.66 0.34 1.18e-10 Vitiligo; CRC cis rs4727027 0.704 rs10952805 chr7:148907849 G/A cg23583168 chr7:148888333 NA -0.93 -17.31 -0.69 3.63e-48 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC cis rs2836950 0.545 rs2297256 chr21:40558421 C/T cg17971929 chr21:40555470 PSMG1 -0.58 -8.55 -0.43 4.78e-16 Menarche (age at onset); CRC cis rs2836974 0.583 rs2410124 chr21:40704760 C/G cg11644478 chr21:40555479 PSMG1 -0.64 -9.81 -0.48 4.14e-20 Cognitive function; CRC cis rs921968 0.643 rs483172 chr2:219428299 A/G cg02176678 chr2:219576539 TTLL4 0.49 7.88 0.4 4.8e-14 Mean corpuscular hemoglobin concentration; CRC cis rs2404602 0.647 rs920712 chr15:77033934 G/A cg03037974 chr15:76606532 NA -0.54 -8.15 -0.41 7.44e-15 Blood metabolite levels; CRC cis rs644799 0.582 rs1727149 chr11:95497171 C/T cg25478527 chr11:95522999 CEP57;FAM76B -0.48 -7.22 -0.37 3.54e-12 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs8060686 0.920 rs3809630 chr16:67879400 G/A cg04539111 chr16:67997858 SLC12A4 -0.48 -5.88 -0.31 9.82e-9 HDL cholesterol;Metabolic syndrome; CRC cis rs9399137 0.507 rs6923512 chr6:135335268 A/G cg24558204 chr6:135376177 HBS1L -0.62 -9.3 -0.46 2.08e-18 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; CRC cis rs720844 0.684 rs34324924 chr2:149307644 T/A cg09247360 chr2:149335327 NA -0.57 -5.98 -0.31 5.8e-9 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs4819052 1.000 rs2297284 chr21:46705345 G/A cg19498844 chr21:46707878 POFUT2;LOC642852 0.84 11.17 0.52 9.11e-25 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs798554 0.757 rs2533878 chr7:2878707 A/G cg19717773 chr7:2847554 GNA12 0.49 6.98 0.36 1.62e-11 Height; CRC cis rs72634258 0.554 rs12723500 chr1:7857374 G/C cg26816564 chr1:7831052 VAMP3 0.93 10.46 0.5 2.63e-22 Inflammatory bowel disease; CRC cis rs10540 1.000 rs61876326 chr11:467368 A/G cg19913688 chr11:428466 ANO9 -0.72 -7.58 -0.39 3.58e-13 Body mass index; CRC cis rs67311347 0.544 rs9864664 chr3:40336226 T/C cg09455208 chr3:40491958 NA 0.32 6.35 0.33 7.07e-10 Renal cell carcinoma; CRC cis rs754466 0.580 rs11002293 chr10:79537965 C/T cg17075019 chr10:79541650 NA -0.95 -17.88 -0.7 1.91e-50 Liver enzyme levels (gamma-glutamyl transferase); CRC trans rs629535 0.862 rs638412 chr8:70047690 C/T cg21567404 chr3:27674614 NA 0.95 16.08 0.66 2.35e-43 Dupuytren's disease; CRC trans rs11098499 0.909 rs9994810 chr4:120381590 A/G cg25214090 chr10:38739885 LOC399744 0.66 10.56 0.5 1.18e-22 Corneal astigmatism; CRC cis rs10504229 0.728 rs17804666 chr8:58154473 C/T cg05313129 chr8:58192883 C8orf71 -0.47 -6.18 -0.32 1.94e-9 Developmental language disorder (linguistic errors); CRC cis rs651907 0.514 rs12636047 chr3:101434449 T/C cg11279151 chr3:101281821 RG9MTD1 -0.55 -7.56 -0.38 4.16e-13 Colorectal cancer; CRC cis rs17253792 0.915 rs77161327 chr14:56178565 A/G cg01858014 chr14:56050164 KTN1 -0.81 -6.11 -0.32 2.87e-9 Putamen volume; CRC cis rs12545109 0.723 rs2610045 chr8:57413439 A/G cg09654669 chr8:57350985 NA 0.38 5.81 0.31 1.45e-8 Obesity-related traits; CRC cis rs2204008 0.657 rs8186888 chr12:38334260 T/G cg26384229 chr12:38710491 ALG10B 0.55 8.01 0.4 2.06e-14 Bladder cancer; CRC cis rs4862750 0.881 rs6813866 chr4:187872161 T/G cg10295955 chr4:187884368 NA -0.99 -22.21 -0.77 2.03e-67 Lobe attachment (rater-scored or self-reported); CRC cis rs11212617 0.905 rs172927 chr11:108124299 G/A cg14761454 chr11:108092087 ATM;NPAT 0.4 5.89 0.31 9.65e-9 Response to metformin in type 2 diabetes (glycemic); CRC cis rs2303759 0.507 rs35042238 chr19:49872941 C/T cg24324837 chr19:49891574 CCDC155 0.6 6.11 0.32 2.84e-9 Multiple sclerosis; CRC trans rs7726839 0.540 rs72703080 chr5:595238 A/G cg25482853 chr8:67687455 SGK3 1.06 12.12 0.56 3.22e-28 Obesity-related traits; CRC cis rs1223397 0.651 rs202016 chr6:13301043 G/A cg20827128 chr6:13274284 PHACTR1 0.37 5.69 0.3 2.8e-8 Blood pressure; CRC cis rs9648716 0.554 rs10235900 chr7:140601438 G/T cg17554604 chr7:140774522 NA 0.44 5.98 0.31 5.85e-9 Type 2 diabetes; CRC cis rs6831352 0.918 rs2602895 chr4:100045840 C/T cg12011299 chr4:100065546 ADH4 0.5 9.54 0.47 3.24e-19 Alcohol dependence; CRC cis rs887829 0.588 rs4663969 chr2:234655313 C/A cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.51 -7.91 -0.4 3.84e-14 Metabolic traits;Bilirubin levels;Cholelithiasis-related traits in sickle cell anemia;Metabolite levels;Total bilirubin levels in HIV-1 infection;Serum metabolite levels;Blood metabolite levels; CRC trans rs12406019 0.548 rs11579434 chr1:78610022 T/C cg20826526 chr3:156266748 SSR3 -0.41 -6.09 -0.32 3.14e-9 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC trans rs459571 0.876 rs2520095 chr9:136919568 A/G cg15028160 chr19:49622717 PPFIA3;C19orf73 -0.55 -6.94 -0.36 2.05e-11 Platelet distribution width; CRC cis rs12142240 0.698 rs112089006 chr1:46812360 C/T cg00530320 chr1:46809349 NSUN4 0.58 7.8 0.4 8.18e-14 Menopause (age at onset); CRC cis rs7605827 0.930 rs10179754 chr2:15541214 C/T cg19274914 chr2:15703543 NA 0.4 5.94 0.31 7.2e-9 Educational attainment (years of education); CRC cis rs3106136 0.546 rs2664881 chr4:95143484 A/G cg11021082 chr4:95130006 SMARCAD1 -0.59 -9.46 -0.46 6.05e-19 Capecitabine sensitivity; CRC cis rs1950626 0.577 rs35097045 chr14:101454403 G/C cg02351406 chr14:101447389 SNORD114-20;SNORD114-21 0.76 12.31 0.56 6.42e-29 Pelvic organ prolapse (moderate/severe); CRC cis rs2576037 0.526 rs6507714 chr18:44519574 A/G cg07643061 chr18:44555308 TCEB3C;TCEB3CL;KATNAL2 -0.36 -5.96 -0.31 6.34e-9 Personality dimensions; CRC cis rs1532331 0.898 rs4498259 chr5:43165943 A/G cg09164108 chr5:43007320 NA -0.39 -6.09 -0.32 3.16e-9 Menarche (age at onset); CRC cis rs6502050 0.835 rs28481866 chr17:80105160 G/A cg02741985 chr17:80059408 CCDC57 0.43 7.15 0.37 5.66e-12 Life satisfaction; CRC cis rs12477438 0.520 rs6756650 chr2:99801800 T/C cg26064155 chr2:99771622 LIPT1;TSGA10 0.87 15.96 0.66 7.31e-43 Chronic sinus infection; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg08083689 chr4:8442326 ACOX3 0.46 6.31 0.33 9.06e-10 Response to antipsychotic treatment; CRC cis rs4363385 0.818 rs6587719 chr1:152993409 G/C cg25856811 chr1:152973957 SPRR3 -0.24 -6.71 -0.35 8.61e-11 Inflammatory skin disease; CRC cis rs13191362 1.000 rs67487119 chr6:163102657 A/C cg21926612 chr6:163149169 PACRG;PARK2 0.98 12.74 0.57 1.73e-30 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs881375 0.678 rs10760125 chr9:123662590 G/A cg09419670 chr9:123605666 PSMD5;LOC253039 0.51 8.11 0.41 9.95e-15 Rheumatoid arthritis; CRC cis rs10504229 0.683 rs56741275 chr8:58136108 C/G cg22535103 chr8:58192502 C8orf71 -0.7 -9.34 -0.46 1.47e-18 Developmental language disorder (linguistic errors); CRC cis rs6427782 0.542 rs11578938 chr1:199892279 C/T cg07208853 chr1:200005219 NR5A2 0.24 6.08 0.32 3.31e-9 Menarche (age at onset); CRC cis rs7917772 0.503 rs11191326 chr10:104302959 C/T cg22532475 chr10:104410764 TRIM8 -0.36 -6.8 -0.35 5.08e-11 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC cis rs889312 0.500 rs185219 chr5:56136492 A/G cg18230493 chr5:56204884 C5orf35 -0.4 -5.91 -0.31 8.61e-9 Breast cancer;Breast cancer (early onset); CRC cis rs12692738 0.526 rs355841 chr2:165622150 G/A cg03182029 chr2:165697222 COBLL1 0.51 5.98 0.31 5.74e-9 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);Waist-to-hip ratio adjusted for BMI in non-smokers;Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction);Waist-to-hip ratio adjusted for body mass index; CRC cis rs4604732 0.631 rs74154676 chr1:247625894 T/C cg02104434 chr1:247694406 LOC148824;OR2C3 0.6 8.82 0.44 6.67e-17 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CRC cis rs7119 0.651 rs12902898 chr15:77849191 A/G cg27398640 chr15:77910606 LINGO1 -0.37 -6.17 -0.32 2e-9 Type 2 diabetes; CRC cis rs1707322 0.686 rs2050376 chr1:46078630 C/T cg06784218 chr1:46089804 CCDC17 0.66 11.91 0.55 1.98e-27 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs7605827 0.930 rs2058866 chr2:15519992 G/T cg19274914 chr2:15703543 NA 0.39 5.9 0.31 8.92e-9 Educational attainment (years of education); CRC cis rs6460942 0.915 rs72584550 chr7:12304990 G/A cg20607287 chr7:12443886 VWDE -0.47 -6.09 -0.32 3.07e-9 Coronary artery disease; CRC cis rs8060686 0.545 rs55897859 chr16:68286748 G/C cg09835421 chr16:68378352 PRMT7 -0.61 -5.64 -0.3 3.73e-8 HDL cholesterol;Metabolic syndrome; CRC cis rs7945705 0.791 rs4579928 chr11:8815704 A/G cg21881798 chr11:8931708 C11orf17;ST5 0.56 9.15 0.45 6.01e-18 Hemoglobin concentration; CRC cis rs9296404 1 rs9296404 chr6:42925803 T/C cg09436375 chr6:42928200 GNMT -0.35 -6.58 -0.34 1.86e-10 Plasma homocysteine levels (post-methionine load test); CRC cis rs7173389 0.530 rs6495064 chr15:73682867 C/T cg01796676 chr15:73680284 NA -0.53 -8.29 -0.42 2.87e-15 Resting heart rate; CRC cis rs6502050 0.835 rs7502078 chr17:80131879 C/A cg19223190 chr17:80058835 NA 0.38 5.96 0.31 6.45e-9 Life satisfaction; CRC cis rs972578 1.000 rs738379 chr22:43400764 G/T cg01576275 chr22:43409880 NA 0.52 8.55 0.43 4.64e-16 Mean platelet volume; CRC cis rs9399137 0.507 rs6923512 chr6:135335268 A/G cg22676075 chr6:135203613 NA -0.58 -8.76 -0.43 1.04e-16 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; CRC trans rs783540 1.000 rs11637433 chr15:83321336 A/G cg18393722 chr15:85113863 UBE2QP1 0.38 6.29 0.33 9.96e-10 Schizophrenia; CRC cis rs950776 0.518 rs8025429 chr15:78836362 G/A cg06917634 chr15:78832804 PSMA4 -0.67 -10.68 -0.51 4.82e-23 Sudden cardiac arrest; CRC cis rs11030122 0.547 rs10835333 chr11:3957766 A/G cg18678763 chr11:4115507 RRM1 -0.35 -6.01 -0.31 4.98e-9 Mean platelet volume;Platelet distribution width; CRC cis rs7412746 0.658 rs11581757 chr1:150892244 A/G cg10589385 chr1:150898437 SETDB1 0.33 7.09 0.36 8.33e-12 Melanoma; CRC cis rs12586317 0.547 rs2038254 chr14:35462134 C/T cg05294307 chr14:35346193 BAZ1A -0.73 -8.21 -0.41 5.01e-15 Psoriasis; CRC cis rs2303745 0.589 rs751599 chr19:17396549 A/G cg02221750 chr19:17393354 ANKLE1 -0.43 -6.56 -0.34 2.05e-10 Systemic lupus erythematosus; CRC cis rs6502050 0.723 rs11650635 chr17:80083816 T/C cg11859384 chr17:80120422 CCDC57 0.37 5.82 0.31 1.36e-8 Life satisfaction; CRC cis rs1865760 0.865 rs6929805 chr6:25950834 T/A cg17691542 chr6:26056736 HIST1H1C 0.55 8.29 0.42 2.87e-15 Height; CRC cis rs4144743 1.000 rs67080286 chr17:45322248 T/G cg18085866 chr17:45331354 ITGB3 -0.6 -8.31 -0.42 2.58e-15 Body mass index; CRC cis rs1552244 0.554 rs3732965 chr3:10048760 A/C cg00166722 chr3:10149974 C3orf24 0.43 6.36 0.33 6.64e-10 Alzheimer's disease; CRC cis rs6754311 0.731 rs4954490 chr2:136608231 G/A cg15123519 chr2:136567270 LCT 0.34 6.51 0.34 2.85e-10 Mosquito bite size; CRC cis rs56235845 0.694 rs11749830 chr5:176766547 G/A cg06060754 chr5:176797920 RGS14 0.52 8.24 0.41 4.11e-15 Hemoglobin concentration;Hematocrit; CRC cis rs847649 1.000 rs847649 chr7:102556011 C/T cg18108683 chr7:102477205 FBXL13 -0.57 -9.33 -0.46 1.61e-18 Morning vs. evening chronotype; CRC cis rs3820068 0.581 rs16851851 chr1:15929628 C/G cg24675056 chr1:15929824 NA 0.49 6.77 0.35 5.87e-11 Systolic blood pressure; CRC cis rs933688 0.938 rs7720235 chr5:90659329 A/T cg02339078 chr5:90679543 LOC100129716;ARRDC3 0.91 15.18 0.64 8.04e-40 Smoking behavior; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg03115081 chr17:74722049 C17orf95;JMJD6 0.44 6.05 0.32 3.87e-9 Response to antipsychotic treatment; CRC cis rs2836950 0.565 rs2836934 chr21:40564885 A/C cg11890956 chr21:40555474 PSMG1 -0.64 -9.56 -0.47 2.92e-19 Menarche (age at onset); CRC trans rs75804782 0.641 rs72983834 chr2:239319895 G/A cg01134436 chr17:81009848 B3GNTL1 0.77 7.02 0.36 1.24e-11 Morning vs. evening chronotype;Chronotype; CRC cis rs9916302 0.660 rs4795379 chr17:37674683 T/G cg15445000 chr17:37608096 MED1 0.36 6.27 0.33 1.12e-9 Glomerular filtration rate (creatinine); CRC cis rs1129187 0.902 rs6907751 chr6:42944850 C/T cg10862848 chr6:42927986 GNMT -0.39 -9.21 -0.45 3.93e-18 Alzheimer's disease in APOE e4+ carriers; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg01423368 chr11:76155379 C11orf30 0.44 6.17 0.32 2.05e-9 Response to antipsychotic treatment; CRC cis rs1800978 0.925 rs12686004 chr9:107653426 C/T cg14313833 chr9:107666037 ABCA1 -0.59 -5.97 -0.31 6.02e-9 Coronary artery disease; CRC cis rs12791968 1.000 rs12791968 chr11:45001490 C/T cg11846598 chr11:44996168 LOC221122 0.72 13.07 0.58 9.7e-32 Inhibitory control; CRC cis rs4713118 0.738 rs200465 chr6:27757654 T/A cg19041857 chr6:27730383 NA -0.44 -6.06 -0.32 3.8e-9 Parkinson's disease; CRC cis rs11190604 1.000 rs7079136 chr10:102292709 T/C cg16342193 chr10:102329863 NA -0.36 -5.94 -0.31 7.21e-9 Palmitoleic acid (16:1n-7) levels; CRC cis rs7552404 1.000 rs11161511 chr1:76210477 A/G cg22875332 chr1:76189707 ACADM -0.61 -8.02 -0.4 1.93e-14 Blood metabolite levels;Acylcarnitine levels; CRC cis rs10504229 1.000 rs59383954 chr8:58189689 G/A cg02725872 chr8:58115012 NA -0.38 -6.43 -0.33 4.44e-10 Developmental language disorder (linguistic errors); CRC cis rs6496667 0.642 rs62019394 chr15:91060730 C/T cg04176472 chr15:90893244 GABARAPL3 0.55 7.88 0.4 4.85e-14 Rheumatoid arthritis; CRC cis rs7666738 0.830 rs13108871 chr4:98803872 T/C cg17366294 chr4:99064904 C4orf37 0.43 6.92 0.36 2.36e-11 Colonoscopy-negative controls vs population controls; CRC cis rs9911578 1.000 rs7216680 chr17:56988243 G/C cg12560992 chr17:57184187 TRIM37 0.91 16.91 0.68 1.27e-46 Intelligence (multi-trait analysis); CRC cis rs12142240 0.698 rs932816 chr1:46859749 G/A cg14993813 chr1:46806288 NSUN4 -0.48 -6.03 -0.32 4.47e-9 Menopause (age at onset); CRC trans rs11088226 0.645 rs11702343 chr21:33937888 C/A cg09050820 chr6:167586206 TCP10L2 0.83 8.71 0.43 1.51e-16 Gastritis; CRC cis rs6424115 0.830 rs1106 chr1:24200772 C/G cg10978503 chr1:24200527 CNR2 0.61 11.06 0.52 2.22e-24 Immature fraction of reticulocytes; CRC cis rs780096 0.546 rs6547626 chr2:27646770 C/T cg27432699 chr2:27873401 GPN1 -0.5 -7.6 -0.39 3.06e-13 Total body bone mineral density; CRC cis rs2832191 0.740 rs2832168 chr21:30463695 G/A cg24692254 chr21:30365293 RNF160 0.85 15.96 0.66 7.32e-43 Dental caries; CRC cis rs9368481 0.729 rs9379948 chr6:26944783 T/G cg18278486 chr6:26987575 LOC100270746;C6orf41 0.41 6.6 0.34 1.62e-10 Autism spectrum disorder or schizophrenia; CRC cis rs4665809 0.759 rs62128394 chr2:26364026 T/G cg04944784 chr2:26401820 FAM59B 0.78 8.24 0.41 4.03e-15 Gut microbiome composition (summer); CRC cis rs4819052 0.851 rs7281263 chr21:46695606 T/C cg11663144 chr21:46675770 NA -0.85 -14.55 -0.63 2.21e-37 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs9311474 0.581 rs13621 chr3:52558133 T/C cg05573699 chr3:52720067 GNL3;PBRM1 -0.4 -5.83 -0.31 1.32e-8 Electroencephalogram traits; CRC cis rs9372498 0.536 rs62421536 chr6:118727972 G/A cg10217327 chr6:118973057 C6orf204 0.52 5.62 0.3 3.98e-8 Diastolic blood pressure; CRC cis rs10256972 0.552 rs6978842 chr7:1204599 A/C cg03188948 chr7:1209495 NA 0.59 8.99 0.44 1.99e-17 Longevity;Endometriosis; CRC cis rs4713118 0.955 rs9393847 chr6:27687973 G/A cg12172441 chr6:28176163 NA 0.49 6.42 0.33 4.77e-10 Parkinson's disease; CRC cis rs9733 0.596 rs17606613 chr1:150683015 C/T cg18016565 chr1:150552671 MCL1 0.45 6.52 0.34 2.57e-10 Tonsillectomy; CRC trans rs747782 0.582 rs11039571 chr11:48207259 G/A cg15704280 chr7:45808275 SEPT13 0.62 6.18 0.32 1.88e-9 Intraocular pressure; CRC cis rs10256972 0.684 rs2363279 chr7:1096143 A/G cg03188948 chr7:1209495 NA 0.42 6.12 0.32 2.65e-9 Longevity;Endometriosis; CRC cis rs7811142 1.000 rs28490152 chr7:100020982 G/A cg00814883 chr7:100076585 TSC22D4 -0.7 -9.2 -0.45 4.22e-18 Platelet count; CRC cis rs853679 1.000 rs13200462 chr6:28218199 A/C cg15845792 chr6:28175446 NA 0.74 7.08 0.36 8.95e-12 Depression; CRC cis rs4481887 0.927 rs7524700 chr1:248472816 A/G cg13385794 chr1:248469461 NA 0.38 6.65 0.34 1.26e-10 Common traits (Other); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg05176131 chr17:48624481 SPATA20 0.4 6.96 0.36 1.81e-11 Liver disease severity in Alagille syndrome; CRC cis rs898097 0.841 rs55810435 chr17:80836722 G/C cg15369054 chr17:80825471 TBCD 0.52 8.48 0.42 7.48e-16 Breast cancer; CRC cis rs752010 0.841 rs7519983 chr1:42083369 C/T cg06885757 chr1:42089581 HIVEP3 0.36 6.57 0.34 1.91e-10 Lupus nephritis in systemic lupus erythematosus; CRC cis rs916888 0.610 rs199529 chr17:44837217 A/C cg15921436 chr17:44337874 NA 0.68 7.48 0.38 6.83e-13 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC trans rs2727020 0.523 rs4115783 chr11:49556026 G/A cg03929089 chr4:120376271 NA 0.77 10.46 0.5 2.67e-22 Coronary artery disease; CRC cis rs9926296 0.585 rs6500450 chr16:89858024 A/G cg27121462 chr16:89883253 FANCA 0.58 9.22 0.45 3.76e-18 Vitiligo; CRC cis rs4319547 0.774 rs7954006 chr12:123131824 A/C cg23029597 chr12:123009494 RSRC2 0.52 6.94 0.36 2.07e-11 Body mass index; CRC cis rs9928842 0.712 rs8057843 chr16:75221555 T/G cg09066997 chr16:75300724 BCAR1 0.65 6.12 0.32 2.67e-9 Alcoholic chronic pancreatitis; CRC cis rs2153535 0.580 rs9406167 chr6:8502852 T/C cg07606381 chr6:8435919 SLC35B3 0.65 10.55 0.5 1.36e-22 Motion sickness; CRC cis rs9560113 1.000 rs9555806 chr13:112179954 G/A cg10483660 chr13:112241077 NA 0.36 5.81 0.3 1.49e-8 Menarche (age at onset); CRC cis rs2228479 0.850 rs11649162 chr16:89807131 C/A cg06558623 chr16:89946397 TCF25 1.14 10.79 0.51 1.99e-23 Skin colour saturation; CRC cis rs5758511 0.680 rs1033460 chr22:42619308 A/G cg00645731 chr22:42541494 CYP2D7P1 0.66 10.24 0.49 1.53e-21 Birth weight; CRC cis rs10493773 0.609 rs12058974 chr1:86192235 T/A cg23216685 chr1:86174607 ZNHIT6 -0.29 -6.75 -0.35 6.73e-11 Urate levels in overweight individuals; CRC cis rs10463316 0.894 rs10042030 chr5:150768028 T/C cg03212797 chr5:150827313 SLC36A1 -0.49 -7.74 -0.39 1.26e-13 Metabolite levels (Pyroglutamine); CRC cis rs2439831 0.702 rs2788 chr15:44064886 A/G cg02155558 chr15:43621948 ADAL;LCMT2 0.69 7.61 0.39 2.95e-13 Lung cancer in ever smokers; CRC cis rs13108904 0.837 rs4519749 chr4:1280102 A/G cg02018176 chr4:1364513 KIAA1530 0.48 7.94 0.4 3.22e-14 Obesity-related traits; CRC cis rs4363385 0.818 rs2879487 chr1:152985360 C/A cg25856811 chr1:152973957 SPRR3 -0.24 -6.71 -0.35 8.48e-11 Inflammatory skin disease; CRC cis rs2637266 0.538 rs11001852 chr10:78445987 G/C cg18941641 chr10:78392320 NA -0.35 -5.83 -0.31 1.31e-8 Pulmonary function; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg19941230 chr17:63051872 GNA13 0.38 6.14 0.32 2.43e-9 Liver disease severity in Alagille syndrome; CRC cis rs6964587 0.967 rs10953065 chr7:91808915 A/G cg17063962 chr7:91808500 NA -0.76 -12.21 -0.56 1.6e-28 Breast cancer; CRC cis rs490234 0.841 rs7856366 chr9:128442229 A/G cg14078157 chr9:128172775 NA -0.37 -6.17 -0.32 2e-9 Mean arterial pressure; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg02167865 chr10:99078850 FRAT1 0.46 6.46 0.34 3.77e-10 Response to antipsychotic treatment; CRC cis rs7811142 0.720 rs7795656 chr7:99950297 A/T cg00814883 chr7:100076585 TSC22D4 -0.68 -8.63 -0.43 2.68e-16 Platelet count; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg12473036 chr20:62611207 SAMD10;PRPF6 0.49 6.73 0.35 7.42e-11 Thyroid stimulating hormone; CRC cis rs2985684 0.625 rs4900931 chr14:50022793 A/T cg23565292 chr14:50234668 KLHDC2 -0.39 -5.61 -0.3 4.36e-8 Carotid intima media thickness; CRC cis rs3771570 0.901 rs73008106 chr2:242422446 C/T cg21155796 chr2:242212141 HDLBP 0.59 6.73 0.35 7.47e-11 Prostate cancer; CRC cis rs2032447 0.714 rs199739 chr6:25960509 A/C cg26028573 chr6:26043587 HIST1H2BB 0.47 6.83 0.35 4.14e-11 Intelligence (multi-trait analysis); CRC cis rs4713118 0.824 rs9468229 chr6:27750086 G/A cg25164649 chr6:28176230 NA 0.6 7.91 0.4 3.87e-14 Parkinson's disease; CRC cis rs6951245 1.000 rs77760339 chr7:1083927 G/T cg24642844 chr7:1081250 C7orf50 -0.78 -9.34 -0.46 1.44e-18 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs3857067 1.000 rs1588381 chr4:95017558 C/T cg11021082 chr4:95130006 SMARCAD1 -0.4 -6.06 -0.32 3.63e-9 QT interval; CRC cis rs6665290 0.669 rs3768423 chr1:227177293 G/A cg10327440 chr1:227177885 CDC42BPA -0.99 -20.58 -0.75 4.64e-61 Myeloid white cell count; CRC cis rs9733 0.526 rs11204696 chr1:150658721 T/C cg17724175 chr1:150552817 MCL1 0.59 9.61 0.47 2.03e-19 Tonsillectomy; CRC trans rs3780486 0.846 rs10738905 chr9:33123627 A/G cg20290983 chr6:43655470 MRPS18A 1.17 27.15 0.83 5.16e-86 IgG glycosylation; CRC cis rs1865760 0.929 rs9461224 chr6:25936402 G/T cg17691542 chr6:26056736 HIST1H1C 0.49 6.38 0.33 6.04e-10 Height; CRC cis rs9325144 0.647 rs35138700 chr12:38804474 C/T cg26384229 chr12:38710491 ALG10B -0.5 -7.32 -0.37 1.97e-12 Morning vs. evening chronotype; CRC cis rs7527798 0.592 rs11118281 chr1:207832102 C/T cg21110645 chr1:207815933 NA -0.38 -5.79 -0.3 1.68e-8 Erythrocyte sedimentation rate; CRC cis rs2477686 0.526 rs1998759 chr1:2397174 C/T cg11214544 chr1:2391121 NA -0.56 -8.96 -0.44 2.54e-17 Non-obstructive azoospermia; CRC trans rs11165623 0.564 rs7525803 chr1:97000791 T/C cg10631902 chr5:14652156 NA -0.4 -6.83 -0.35 4.13e-11 Hip circumference;Waist circumference; CRC cis rs8013055 0.796 rs4075105 chr14:106000231 C/T cg23356831 chr14:105996513 TMEM121 0.41 6.98 0.36 1.59e-11 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis); CRC cis rs12188164 0.965 rs1056465 chr5:442438 T/A cg16322479 chr5:444228 EXOC3;C5orf55 0.5 8.07 0.41 1.33e-14 Cystic fibrosis severity; CRC cis rs4862750 0.914 rs1991255 chr4:187875340 G/A cg11301795 chr4:187892539 NA -0.84 -18.62 -0.72 2.33e-53 Lobe attachment (rater-scored or self-reported); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg15871991 chr2:10829907 NOL10 0.43 5.99 0.31 5.47e-9 Response to antipsychotic treatment; CRC cis rs738322 0.967 rs4385 chr22:38573229 T/C cg17652424 chr22:38574118 PLA2G6 -0.22 -6.92 -0.36 2.44e-11 Cutaneous nevi; CRC cis rs10783615 0.719 rs1975471 chr12:54336981 A/G cg25382128 chr12:54346509 NA -0.51 -6.57 -0.34 2.01e-10 Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction);Waist-to-hip ratio adjusted for BMI in non-smokers;Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour); CRC cis rs7618915 0.547 rs12496476 chr3:52708737 A/G cg10802521 chr3:52805072 NEK4 -0.58 -8.85 -0.44 5.34e-17 Bipolar disorder; CRC cis rs9611565 0.729 rs12165508 chr22:41819960 T/C cg06634786 chr22:41940651 POLR3H 0.44 5.62 0.3 4.06e-8 Vitiligo; CRC trans rs17641971 0.862 rs341817 chr8:50023600 A/C cg18784943 chr17:79371681 NA 0.39 5.96 0.31 6.47e-9 Blood metabolite levels; CRC cis rs2730245 0.527 rs2527194 chr7:158732959 G/A cg24397884 chr7:158709396 WDR60 -0.98 -11.62 -0.54 2.16e-26 Height; CRC cis rs2579500 0.807 rs11891926 chr2:97339781 A/G cg23100626 chr2:96804247 ASTL -0.23 -5.67 -0.3 3.09e-8 Eosinophil counts;Eosinophil percentage of white cells; CRC cis rs2882667 1.000 rs10515505 chr5:138313146 A/G cg09476006 chr5:138032270 NA 0.46 7.6 0.39 3.04e-13 Age-related hearing impairment (SNP x SNP interaction); CRC trans rs1814175 0.765 rs11493326 chr11:50018063 T/C cg03929089 chr4:120376271 NA -0.93 -17.54 -0.7 4.43e-49 Height; CRC cis rs7635838 0.617 rs346071 chr3:11305584 A/T cg00170343 chr3:11313890 ATG7 -0.59 -9.31 -0.46 1.81e-18 HDL cholesterol; CRC cis rs1023500 0.505 rs134888 chr22:42674281 C/T cg15557168 chr22:42548783 NA -0.36 -6.15 -0.32 2.25e-9 Schizophrenia; CRC cis rs4665809 0.590 rs13016300 chr2:26468365 G/C cg27170947 chr2:26402098 FAM59B 0.59 7.71 0.39 1.53e-13 Gut microbiome composition (summer); CRC cis rs524281 0.773 rs7951079 chr11:65980550 C/T cg14036092 chr11:66035641 RAB1B -0.54 -5.87 -0.31 1.04e-8 Electroencephalogram traits; CRC cis rs7647973 0.626 rs1463728 chr3:49647404 T/A cg13072238 chr3:49761600 GMPPB -0.52 -5.86 -0.31 1.11e-8 Menarche (age at onset); CRC cis rs2952156 0.883 rs12150603 chr17:37834715 G/A cg00129232 chr17:37814104 STARD3 -0.71 -12.79 -0.58 1.07e-30 Asthma; CRC cis rs4234798 0.605 rs4689637 chr4:7211197 A/G cg18431297 chr4:7219810 SORCS2 0.48 7.41 0.38 1.08e-12 Insulin-like growth factors; CRC cis rs9346649 0.654 rs35453512 chr6:168491906 C/G cg02770688 chr6:168491649 NA 0.62 9.16 0.45 5.86e-18 Venous thromboembolism adjusted for sickle cell variant rs77121243-T; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg21036854 chr14:77506705 NA 0.52 7.54 0.38 4.74e-13 Response to antipsychotic treatment; CRC cis rs2153535 0.526 rs1796689 chr6:8536433 A/C cg21535247 chr6:8435926 SLC35B3 0.51 7.79 0.39 9.12e-14 Motion sickness; CRC cis rs7618915 0.501 rs12486554 chr3:52742537 A/T cg18404041 chr3:52824283 ITIH1 -0.4 -8.47 -0.42 8.31e-16 Bipolar disorder; CRC cis rs1539053 0.934 rs1524708 chr1:58102590 T/A cg20292791 chr1:58089357 DAB1 -0.33 -5.79 -0.3 1.69e-8 Plasma omega-6 polyunsaturated fatty acid levels (arachidonic acid); CRC cis rs4601790 0.601 rs4930295 chr11:65390554 C/G cg21033440 chr11:65409861 SIPA1 -0.65 -8.27 -0.41 3.4e-15 Blood pressure (age interaction); CRC cis rs10504229 0.683 rs58883273 chr8:58138275 A/G cg05313129 chr8:58192883 C8orf71 -0.43 -6.11 -0.32 2.74e-9 Developmental language disorder (linguistic errors); CRC cis rs3820068 0.603 rs72647128 chr1:15963908 T/C cg24675056 chr1:15929824 NA 0.51 7.06 0.36 9.73e-12 Systolic blood pressure; CRC cis rs9547692 0.938 rs7333607 chr13:37462010 A/G cg01493522 chr13:37497338 NA -0.52 -7.2 -0.37 4.21e-12 Coronary artery disease; CRC cis rs3617 0.532 rs9836499 chr3:52904524 G/T cg15147215 chr3:52552868 STAB1 0.44 7.4 0.38 1.18e-12 Red blood cell count;Autism spectrum disorder or schizophrenia; CRC cis rs4862750 0.872 rs6852907 chr4:187897094 A/C cg03647317 chr4:187891568 NA -0.53 -9.9 -0.48 2.14e-20 Lobe attachment (rater-scored or self-reported); CRC cis rs7208859 0.623 rs9912440 chr17:29148772 A/G cg13385521 chr17:29058706 SUZ12P 0.75 8.4 0.42 1.35e-15 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs3741151 0.686 rs7123985 chr11:73260463 A/C cg17517138 chr11:73019481 ARHGEF17 0.55 5.62 0.3 4.03e-8 GIP levels in response to oral glucose tolerance test (120 minutes); CRC cis rs6951245 0.872 rs75493422 chr7:1072890 C/T cg07217954 chr7:1067459 C7orf50 0.55 5.68 0.3 3.04e-8 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs9311474 0.629 rs11709284 chr3:52559705 G/A cg11645453 chr3:52864694 ITIH4 0.33 6.22 0.32 1.49e-9 Electroencephalogram traits; CRC cis rs4713118 0.869 rs9295742 chr6:27702832 G/A cg06470822 chr6:28175283 NA 0.71 10.07 0.49 5.85e-21 Parkinson's disease; CRC cis rs2153535 0.606 rs11243253 chr6:8380193 T/C cg07606381 chr6:8435919 SLC35B3 -0.66 -10.47 -0.5 2.5e-22 Motion sickness; CRC cis rs1448094 0.512 rs12309296 chr12:86241566 T/C cg02569458 chr12:86230093 RASSF9 0.42 7.24 0.37 3.17e-12 Major depressive disorder; CRC cis rs2996428 0.561 rs2275827 chr1:3746585 T/G cg13057898 chr1:3703894 LRRC47 0.57 7.69 0.39 1.69e-13 Red cell distribution width; CRC cis rs10242455 0.702 rs58348977 chr7:99188014 G/A cg18809830 chr7:99032528 PTCD1 -1.18 -8.08 -0.41 1.23e-14 Blood metabolite levels; CRC cis rs7493 1.000 rs6968305 chr7:95042529 G/A cg17330251 chr7:94953956 PON1 -0.56 -7.21 -0.37 3.86e-12 Yu-Zhi constitution type in type 2 diabetes; CRC trans rs2727020 0.729 rs1164666 chr11:49295867 C/T cg15704280 chr7:45808275 SEPT13 -0.91 -16.53 -0.67 4e-45 Coronary artery disease; CRC cis rs8072100 0.871 rs7206971 chr17:45425115 A/G cg08085267 chr17:45401833 C17orf57 0.71 12.16 0.56 2.36e-28 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs9302690 0.793 rs16956811 chr16:57444002 G/T cg27017172 chr16:57497170 POLR2C -0.55 -5.9 -0.31 9.25e-9 Blood protein levels; CRC cis rs2235649 0.833 rs55684627 chr16:1848817 G/A cg00935504 chr16:1863053 HAGH 0.31 5.65 0.3 3.39e-8 Blood metabolite levels; CRC trans rs1814175 0.587 rs7937757 chr11:49978342 G/A cg03929089 chr4:120376271 NA -0.91 -16.17 -0.67 1.06e-43 Height; CRC cis rs4713118 0.869 rs6902689 chr6:27709441 C/T cg15845792 chr6:28175446 NA 0.65 8.93 0.44 2.99e-17 Parkinson's disease; CRC trans rs7824557 0.527 rs2572448 chr8:11239352 G/A cg06636001 chr8:8085503 FLJ10661 -0.44 -6.42 -0.33 4.77e-10 Retinal vascular caliber; CRC cis rs7552404 0.924 rs7544117 chr1:76158246 A/G cg10523679 chr1:76189770 ACADM 0.93 14.17 0.62 6.79e-36 Blood metabolite levels;Acylcarnitine levels; CRC cis rs9388451 0.626 rs2875881 chr6:126072853 C/G cg05901451 chr6:126070800 HEY2 -0.54 -9.01 -0.45 1.66e-17 Brugada syndrome; CRC cis rs8078723 0.690 rs56326707 chr17:38130139 C/T cg17467752 chr17:38218738 THRA 0.61 9.47 0.46 5.49e-19 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); CRC cis rs7192750 0.527 rs30433 chr16:72145404 T/C cg14768367 chr16:72042858 DHODH 0.76 6.02 0.32 4.6e-9 LDL cholesterol levels;Total cholesterol levels; CRC cis rs73206853 0.764 rs7953794 chr12:111081197 A/G cg12870014 chr12:110450643 ANKRD13A 0.79 9.98 0.48 1.14e-20 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC cis rs875971 1.000 rs4717292 chr7:65895598 G/A cg11764359 chr7:65958608 NA 0.62 9.91 0.48 1.96e-20 Aortic root size; CRC cis rs9902453 0.933 rs7216487 chr17:28502642 C/A cg26525008 chr17:28256777 EFCAB5;SSH2 0.6 9.43 0.46 7.7e-19 Coffee consumption (cups per day); CRC cis rs4975709 0.589 rs1466606 chr5:1865055 C/T cg06654549 chr5:1875058 NA 0.4 5.92 0.31 7.98e-9 Cardiovascular disease risk factors; CRC cis rs524023 1.000 rs559946 chr11:64358605 T/C cg06522879 chr11:64358276 SLC22A12 0.57 8.95 0.44 2.62e-17 Urate levels in obese individuals; CRC cis rs981621 0.704 rs2867876 chr18:13316130 C/G cg23768505 chr18:13262434 C18orf1 0.37 5.61 0.3 4.2e-8 Survival in pancreatic cancer; CRC cis rs7647973 0.961 rs6778080 chr3:49317338 C/T cg20833759 chr3:49053208 WDR6;DALRD3 -0.51 -7.73 -0.39 1.34e-13 Menarche (age at onset); CRC cis rs3733585 0.699 rs6449159 chr4:9960498 G/A cg00071950 chr4:10020882 SLC2A9 -0.54 -9.65 -0.47 1.42e-19 Cleft plate (environmental tobacco smoke interaction); CRC cis rs6860806 0.603 rs112300250 chr5:131583292 G/A cg02033258 chr5:131593261 PDLIM4 0.4 7.74 0.39 1.26e-13 Breast cancer; CRC cis rs11971779 0.680 rs7799598 chr7:139051833 C/T cg07862535 chr7:139043722 LUC7L2 0.57 7.32 0.37 1.97e-12 Diisocyanate-induced asthma; CRC trans rs853679 0.607 rs13190888 chr6:28285985 G/A cg01620082 chr3:125678407 NA -0.81 -6.31 -0.33 8.98e-10 Depression; CRC cis rs1448094 1.000 rs7305284 chr12:86343786 C/T cg19622623 chr12:86230825 RASSF9 -0.35 -5.62 -0.3 4.12e-8 Major depressive disorder; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg10727759 chr12:50017361 PRPF40B -0.39 -5.96 -0.31 6.43e-9 Myopia (pathological); CRC cis rs9309473 0.718 rs6546829 chr2:73613789 C/G cg20560298 chr2:73613845 ALMS1 -0.56 -7.49 -0.38 6.29e-13 Metabolite levels; CRC cis rs847577 0.630 rs11764933 chr7:97825188 G/A cg00277769 chr7:97922759 BAIAP2L1 -0.41 -6.88 -0.35 2.99e-11 Breast cancer; CRC trans rs12599106 0.792 rs11648801 chr16:34360980 C/T cg11235426 chr6:292522 DUSP22 -0.54 -7.64 -0.39 2.38e-13 Menopause (age at onset); CRC cis rs13082711 0.954 rs35523848 chr3:27552800 A/C cg02860705 chr3:27208620 NA 0.58 7.43 0.38 9.49e-13 Systolic blood pressure;Diastolic blood pressure;Blood pressure; CRC cis rs6502050 0.698 rs36043222 chr17:80117822 G/T cg19223190 chr17:80058835 NA 0.38 6.17 0.32 2e-9 Life satisfaction; CRC cis rs367615 0.704 rs7705399 chr5:108850351 G/C cg17395555 chr5:108820864 NA 0.46 9.25 0.45 2.98e-18 Colorectal cancer (SNP x SNP interaction); CRC cis rs365302 1.000 rs481899 chr6:159651671 T/C cg14500486 chr6:159655392 FNDC1 0.44 6.82 0.35 4.31e-11 Coronary heart disease; CRC cis rs35110281 0.744 rs8131027 chr21:45104908 G/C cg04455712 chr21:45112962 RRP1B 0.4 7.75 0.39 1.14e-13 Mean corpuscular volume; CRC cis rs17767392 0.881 rs8006300 chr14:72050162 C/T cg13720639 chr14:72061746 SIPA1L1 0.5 6.19 0.32 1.8e-9 Mitral valve prolapse; CRC cis rs6951245 0.638 rs4720486 chr7:1146764 G/A cg18297960 chr7:1142765 C7orf50 -0.42 -5.72 -0.3 2.42e-8 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs16924133 0.793 rs11032160 chr11:33162040 C/T cg05567920 chr11:33183001 CSTF3 -0.78 -5.92 -0.31 7.95e-9 Anger; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg02926368 chr1:202310824 UBE2T 0.52 6.61 0.34 1.53e-10 Thyroid stimulating hormone; CRC cis rs1008375 0.931 rs7672369 chr4:17604825 A/G cg16339924 chr4:17578868 LAP3 0.51 6.66 0.34 1.13e-10 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs2991971 1.000 rs622798 chr1:46015271 T/G cg15605315 chr1:45957053 TESK2 0.42 6.68 0.35 1.03e-10 High light scatter reticulocyte count; CRC cis rs11750568 0.935 rs10070609 chr5:178524969 T/C cg10208897 chr5:178548229 ADAMTS2 0.35 5.69 0.3 2.81e-8 Height; CRC cis rs748404 0.650 rs518261 chr15:43573429 A/T cg02155558 chr15:43621948 ADAL;LCMT2 0.45 6.68 0.35 1.03e-10 Lung cancer; CRC cis rs4664293 1.000 rs11676412 chr2:160508071 G/T cg08347373 chr2:160653686 CD302 -0.38 -6.24 -0.33 1.38e-9 Monocyte percentage of white cells; CRC cis rs6545883 0.929 rs2600663 chr2:61540687 A/G cg15711740 chr2:61764176 XPO1 0.45 6.24 0.33 1.37e-9 Tuberculosis; CRC cis rs28386778 0.901 rs2854194 chr17:61952110 T/G cg06873352 chr17:61820015 STRADA 0.77 14.38 0.62 9.97e-37 Prudent dietary pattern; CRC cis rs2857891 0.909 rs17191140 chr11:6944283 G/A cg14883916 chr11:6947541 ZNF215 0.61 6.45 0.34 3.93e-10 Response to cytadine analogues (cytosine arabinoside); CRC cis rs7772486 0.806 rs2253648 chr6:146199296 G/A cg13319975 chr6:146136371 FBXO30 -0.39 -5.88 -0.31 9.9e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs4243830 0.850 rs13513 chr1:6585804 C/T cg05709478 chr1:6581295 PLEKHG5 -0.6 -7.29 -0.37 2.4e-12 Body mass index; CRC cis rs2243480 1.000 rs316321 chr7:65611613 G/A cg12463550 chr7:65579703 CRCP 0.73 6.61 0.34 1.55e-10 Diabetic kidney disease; CRC cis rs10992471 0.756 rs2761681 chr9:95186937 A/G cg14631576 chr9:95140430 CENPP -0.4 -7.4 -0.38 1.13e-12 Visceral adipose tissue/subcutaneous adipose tissue ratio; CRC cis rs2243480 0.803 rs35480979 chr7:65357084 A/G cg18252515 chr7:66147081 NA -1.17 -13.57 -0.6 1.26e-33 Diabetic kidney disease; CRC cis rs7591163 1.000 rs4487084 chr2:228713179 G/A cg22079747 chr2:228736145 WDR69 -0.44 -5.88 -0.31 1.01e-8 Blood pressure; CRC cis rs4728142 0.604 rs7807018 chr7:128640188 A/G cg06630958 chr7:128577819 IRF5 -0.35 -5.67 -0.3 3.11e-8 Inflammatory bowel disease;Systemic lupus erythematosus;Ulcerative colitis; CRC cis rs9549328 0.700 rs2185001 chr13:113616369 G/T cg17524180 chr13:113633600 MCF2L -0.62 -11.32 -0.53 2.59e-25 Systolic blood pressure; CRC cis rs11212617 0.967 rs1583598 chr11:108305989 G/A cg14761454 chr11:108092087 ATM;NPAT 0.39 5.7 0.3 2.71e-8 Response to metformin in type 2 diabetes (glycemic); CRC trans rs9858542 0.953 rs9811982 chr3:49624377 A/C cg21665057 chr3:196295764 WDR53;FBXO45 -0.72 -9.83 -0.48 3.74e-20 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs7255436 0.965 rs7351098 chr19:8451671 G/C cg10174797 chr19:8464628 RAB11B 0.44 7.7 0.39 1.62e-13 HDL cholesterol; CRC cis rs57590327 0.528 rs13086292 chr3:81705368 G/A cg07356753 chr3:81810745 GBE1 -0.65 -8.51 -0.42 6.07e-16 Extraversion; CRC cis rs4665809 0.549 rs72809635 chr2:26411674 G/A cg27170947 chr2:26402098 FAM59B 0.67 8.02 0.4 1.83e-14 Gut microbiome composition (summer); CRC cis rs56307353 0.753 rs34318825 chr19:1961342 T/C cg02376178 chr19:1969988 CSNK1G2 0.59 9.35 0.46 1.4e-18 Coronary artery disease; CRC cis rs4731207 0.596 rs10954051 chr7:124579236 T/C cg23710748 chr7:124431027 NA -0.39 -6.12 -0.32 2.67e-9 Cutaneous malignant melanoma; CRC cis rs17401966 0.838 rs1556916 chr1:10403482 G/A cg19773385 chr1:10388646 KIF1B -0.67 -10.86 -0.51 1.1e-23 Hepatocellular carcinoma; CRC cis rs847649 0.599 rs13232194 chr7:102742554 T/A cg18108683 chr7:102477205 FBXL13 0.54 8.66 0.43 2.08e-16 Morning vs. evening chronotype; CRC cis rs9463078 0.715 rs7738526 chr6:45168417 C/A cg25276700 chr6:44698697 NA -0.24 -5.95 -0.31 7e-9 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; CRC cis rs10857712 0.528 rs2265638 chr10:135217175 A/G cg01444801 chr10:135216882 MTG1 -0.41 -6.11 -0.32 2.8e-9 Systemic lupus erythematosus; CRC cis rs9992667 1.000 rs10032639 chr4:38674728 A/T cg19726192 chr4:38663646 FLJ13197 -0.71 -8.91 -0.44 3.47e-17 Eosinophil percentage of granulocytes; CRC cis rs4665809 0.627 rs35461456 chr2:26482361 C/G cg27170947 chr2:26402098 FAM59B 0.6 7.82 0.4 7.45e-14 Gut microbiome composition (summer); CRC cis rs2404602 0.692 rs7169663 chr15:77192843 A/C cg23625390 chr15:77176239 SCAPER 0.47 6.59 0.34 1.76e-10 Blood metabolite levels; CRC cis rs6860806 0.507 rs635619 chr5:131720265 G/A cg24060327 chr5:131705240 SLC22A5 0.51 7.67 0.39 2.02e-13 Breast cancer; CRC trans rs1941687 0.563 rs9953034 chr18:31335294 A/G cg27147174 chr7:100797783 AP1S1 -0.38 -6.22 -0.32 1.48e-9 Subjective well-being (multi-trait analysis);Subjective well-being; CRC cis rs12451471 0.637 rs12950757 chr17:78096800 T/G cg08347473 chr17:78092826 GAA -0.37 -6.02 -0.32 4.65e-9 Plateletcrit;Mean corpuscular hemoglobin concentration; CRC cis rs4862750 0.872 rs13143414 chr4:187878213 G/A cg06074448 chr4:187884817 NA -0.59 -11.23 -0.53 5.58e-25 Lobe attachment (rater-scored or self-reported); CRC cis rs6684514 1.000 rs12027103 chr1:156244856 G/A cg16558208 chr1:156270281 VHLL 0.59 9.2 0.45 4.08e-18 Mean corpuscular hemoglobin concentration;Glycated hemoglobin levels; CRC cis rs9309473 1.000 rs6753344 chr2:73653138 C/T cg20560298 chr2:73613845 ALMS1 0.46 5.75 0.3 2.07e-8 Metabolite levels; CRC cis rs17826219 0.568 rs9907834 chr17:29154013 G/A cg01831904 chr17:28903510 LRRC37B2 -0.61 -6.43 -0.33 4.58e-10 Body mass index; CRC cis rs881375 0.678 rs10760129 chr9:123700183 T/C cg14255062 chr9:123606675 PSMD5;LOC253039 0.4 6.41 0.33 5.06e-10 Rheumatoid arthritis; CRC cis rs801193 0.569 rs7800620 chr7:66223688 T/C cg18876405 chr7:65276391 NA 0.51 8.25 0.41 3.87e-15 Aortic root size; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg18892560 chr6:18264287 DEK 0.44 6.46 0.34 3.78e-10 Intelligence (multi-trait analysis); CRC cis rs736408 0.609 rs1029871 chr3:52797634 G/C cg05573699 chr3:52720067 GNL3;PBRM1 -0.44 -6.23 -0.33 1.4e-9 Bipolar disorder; CRC cis rs9787249 0.915 rs58589165 chr1:40213670 A/T cg02773041 chr1:40204384 PPIE 0.64 9.5 0.46 4.57e-19 Blood protein levels; CRC trans rs7937682 0.921 rs10789841 chr11:111469582 T/C cg18187862 chr3:45730750 SACM1L -0.55 -7.09 -0.36 8.19e-12 Primary sclerosing cholangitis; CRC cis rs12477438 0.501 rs11688004 chr2:99735052 G/T cg26064155 chr2:99771622 LIPT1;TSGA10 0.78 13.46 0.6 3.33e-33 Chronic sinus infection; CRC cis rs910316 1.000 rs10138183 chr14:75615227 T/C cg11812906 chr14:75593930 NEK9 0.66 10.75 0.51 2.61e-23 Height; CRC cis rs6565180 0.962 rs6565182 chr16:30374381 C/T cg17640201 chr16:30407289 ZNF48 -0.77 -12.21 -0.56 1.51e-28 Tonsillectomy; CRC cis rs4665809 0.590 rs4665840 chr2:26444962 C/T cg22920501 chr2:26401640 FAM59B -0.83 -11.96 -0.55 1.28e-27 Gut microbiome composition (summer); CRC cis rs4819052 0.851 rs7279011 chr21:46655995 G/A cg02159808 chr21:46707872 POFUT2;LOC642852 0.5 6.33 0.33 8.26e-10 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs2797160 0.651 rs6939969 chr6:126034563 C/T cg05901451 chr6:126070800 HEY2 0.5 8.16 0.41 7.17e-15 Endometrial cancer; CRC cis rs11711311 1.000 rs9826808 chr3:113455644 A/G cg15478005 chr3:113465772 ATP6V1A;NAA50 0.45 6.15 0.32 2.19e-9 IgG glycosylation; CRC cis rs754466 0.512 rs67607593 chr10:79649050 A/G cg17075019 chr10:79541650 NA -0.87 -14.56 -0.63 2.09e-37 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs7208859 0.673 rs61223749 chr17:29163747 G/A cg13385521 chr17:29058706 SUZ12P 0.69 8.07 0.41 1.34e-14 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs10883723 0.810 rs6584507 chr10:104254623 G/A cg22532475 chr10:104410764 TRIM8 -0.37 -6.86 -0.35 3.51e-11 Allergic disease (asthma, hay fever or eczema); CRC cis rs1443512 0.773 rs2366146 chr12:54331002 G/A cg17410650 chr12:54324560 NA -0.36 -6.69 -0.35 9.77e-11 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for BMI in non-smokers;Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction);Waist-hip ratio;Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour); CRC cis rs4819052 1.000 rs13052356 chr21:46663588 G/A cg11663144 chr21:46675770 NA -0.8 -11.78 -0.54 5.67e-27 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs7677751 0.806 rs7689569 chr4:55096398 G/A cg17187183 chr4:55093834 PDGFRA 0.52 7.53 0.38 4.99e-13 Corneal astigmatism; CRC cis rs4808199 0.842 rs11085259 chr19:19445856 C/T cg03709012 chr19:19516395 GATAD2A 0.96 11.1 0.52 1.55e-24 Nonalcoholic fatty liver disease; CRC cis rs4713118 0.955 rs9468204 chr6:27688809 C/T cg25164649 chr6:28176230 NA 0.54 7.25 0.37 2.92e-12 Parkinson's disease; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg09732282 chr15:58474918 AQP9 0.46 6.49 0.34 3.08e-10 Thyroid stimulating hormone; CRC cis rs2952156 0.959 rs2952151 chr17:37828496 T/C cg00129232 chr17:37814104 STARD3 -0.68 -11.27 -0.53 3.78e-25 Asthma; CRC cis rs17155006 0.664 rs371024 chr7:107741055 A/G cg05962710 chr7:107745446 LAMB4 -0.43 -7.57 -0.39 3.74e-13 Pneumococcal bacteremia; CRC cis rs6952808 0.717 rs6967442 chr7:1926090 A/G cg20295408 chr7:1910781 MAD1L1 -0.42 -6.5 -0.34 2.93e-10 Bipolar disorder and schizophrenia; CRC cis rs6951245 1.000 rs75016635 chr7:1094121 G/A cg20603222 chr7:1096387 C7orf50;GPR146 -0.73 -8.79 -0.44 8.53e-17 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs2019137 0.560 rs11123172 chr2:113984303 C/T cg01577475 chr2:114033581 PAX8;LOC440839 0.24 6.06 0.32 3.65e-9 Lymphocyte counts; CRC cis rs7666738 0.962 rs1527515 chr4:99025733 C/A cg17366294 chr4:99064904 C4orf37 0.44 6.99 0.36 1.53e-11 Colonoscopy-negative controls vs population controls; CRC cis rs10504073 0.545 rs4406405 chr8:49957261 G/C cg00325661 chr8:49890786 NA 0.59 10.66 0.51 5.37e-23 Blood metabolite ratios; CRC cis rs116095464 0.558 rs10043002 chr5:226753 G/A cg22857025 chr5:266934 NA -1.21 -16.5 -0.67 5.53e-45 Breast cancer; CRC cis rs9649465 0.967 rs6944031 chr7:123299304 T/C cg03229431 chr7:123269106 ASB15 -0.37 -5.62 -0.3 3.99e-8 Migraine; CRC trans rs1455244 0.700 rs7229302 chr18:11508904 G/T cg07220488 chr17:77006061 CANT1 0.4 6.14 0.32 2.34e-9 Schizophrenia; CRC cis rs2718058 0.519 rs2598054 chr7:37884640 C/T cg24998770 chr7:37888106 TXNDC3 0.38 6.13 0.32 2.53e-9 Alzheimer's disease (late onset); CRC cis rs10504229 0.906 rs58251024 chr8:58172259 G/C cg01721255 chr8:58191610 C8orf71 0.49 6.17 0.32 2e-9 Developmental language disorder (linguistic errors); CRC cis rs3768617 0.510 rs12091137 chr1:183075732 A/G ch.1.3577855R chr1:183094577 LAMC1 0.87 15.5 0.65 4.55e-41 Fuchs's corneal dystrophy; CRC cis rs13256369 0.708 rs11249886 chr8:8562021 T/A cg18904891 chr8:8559673 CLDN23 0.53 7.13 0.37 6.34e-12 Obesity-related traits; CRC cis rs9674544 0.646 rs6504594 chr17:47142697 C/A cg10950924 chr17:47092072 IGF2BP1 -0.34 -5.84 -0.31 1.27e-8 Primary tooth development (time to first tooth eruption);Primary tooth development (number of teeth); CRC trans rs34421088 0.576 rs2572436 chr8:11099209 C/T cg06636001 chr8:8085503 FLJ10661 -0.44 -6.04 -0.32 4.2e-9 Neuroticism; CRC cis rs67340775 0.541 rs200979 chr6:27852357 G/A cg19041857 chr6:27730383 NA -0.63 -6.79 -0.35 5.27e-11 Lung cancer in ever smokers; CRC cis rs4750440 0.706 rs10906555 chr10:14016879 G/A cg00551146 chr10:14014579 FRMD4A 0.35 5.71 0.3 2.57e-8 Adiponectin levels; CRC cis rs11098499 0.743 rs11098501 chr4:120252017 T/G cg24375607 chr4:120327624 NA 0.47 7.6 0.39 3.06e-13 Corneal astigmatism; CRC cis rs853679 0.550 rs1233701 chr6:28168726 C/G cg25164649 chr6:28176230 NA -0.8 -11.58 -0.54 2.96e-26 Depression; CRC cis rs826838 1.000 rs10880826 chr12:38672787 G/C cg26384229 chr12:38710491 ALG10B 0.72 10.22 0.49 1.81e-21 Heart rate; CRC cis rs9457247 0.602 rs6456152 chr6:167472062 A/G cg07741184 chr6:167504864 NA 0.44 7.41 0.38 1.11e-12 Crohn's disease; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg09351035 chr11:748060 TALDO1 0.47 6.54 0.34 2.35e-10 Response to antipsychotic treatment; CRC cis rs11098499 0.604 rs10022185 chr4:120571765 C/G cg09307838 chr4:120376055 NA 0.66 9.74 0.47 7.24e-20 Corneal astigmatism; CRC cis rs9311474 0.629 rs7639267 chr3:52568805 G/T cg18591801 chr3:52553433 STAB1 -0.31 -6.06 -0.32 3.82e-9 Electroencephalogram traits; CRC cis rs2075371 0.501 rs1646654 chr7:134027547 G/C cg02659138 chr7:134003124 SLC35B4 0.35 5.7 0.3 2.68e-8 Mean platelet volume; CRC cis rs7781266 0.790 rs17654334 chr7:133083234 C/T cg03336402 chr7:133662267 EXOC4 0.51 5.99 0.31 5.39e-9 Educational attainment (college completion); CRC cis rs28386778 0.897 rs4968663 chr17:61835603 A/T cg25654072 chr17:61904446 PSMC5;FTSJ3 0.71 11.11 0.52 1.42e-24 Prudent dietary pattern; CRC cis rs853679 0.517 rs9380057 chr6:28104634 G/T cg12963246 chr6:28129442 ZNF389 0.49 5.78 0.3 1.73e-8 Depression; CRC cis rs6121246 0.909 rs57726761 chr20:30314046 A/G cg13852791 chr20:30311386 BCL2L1 0.69 11.42 0.53 1.18e-25 Mean corpuscular hemoglobin; CRC cis rs9902453 0.874 rs3936006 chr17:28257660 A/G cg26525008 chr17:28256777 EFCAB5;SSH2 0.7 11.54 0.54 4.38e-26 Coffee consumption (cups per day); CRC cis rs10791097 0.694 rs10894275 chr11:130756251 C/T cg12179176 chr11:130786555 SNX19 0.75 12.44 0.57 2.28e-29 Autism spectrum disorder or schizophrenia;Schizophrenia; CRC trans rs12310956 0.532 rs11494810 chr12:33952881 C/A cg26384229 chr12:38710491 ALG10B 0.48 6.5 0.34 2.93e-10 Morning vs. evening chronotype; CRC cis rs539096 0.500 rs2367804 chr1:44314266 C/T cg13606994 chr1:44402422 ARTN -0.35 -5.93 -0.31 7.75e-9 Intelligence (multi-trait analysis); CRC cis rs4481887 1.000 rs4244183 chr1:248471222 G/A cg13385794 chr1:248469461 NA 0.38 6.73 0.35 7.57e-11 Common traits (Other); CRC cis rs7617773 0.817 rs13094727 chr3:48323489 G/A cg11946769 chr3:48343235 NME6 0.73 9.78 0.47 5.53e-20 Coronary artery disease; CRC cis rs12134245 0.747 rs11164912 chr1:92005191 A/T cg21854759 chr1:92012499 NA -0.53 -8.79 -0.44 8.46e-17 Breast cancer; CRC cis rs79387448 0.638 rs11465698 chr2:103054577 T/C cg09003973 chr2:102972529 NA 0.86 9.21 0.45 3.82e-18 Gut microbiota (bacterial taxa); CRC cis rs713477 0.654 rs11158040 chr14:55914607 T/C cg21836586 chr14:55907198 TBPL2 0.35 6.44 0.33 4.32e-10 Pediatric bone mineral content (femoral neck); CRC cis rs2243480 1.000 rs6974723 chr7:65637939 C/T cg18252515 chr7:66147081 NA 1.23 14.37 0.62 1.07e-36 Diabetic kidney disease; CRC cis rs6502050 0.835 rs8073351 chr17:80127625 A/G cg09264619 chr17:80180166 NA -0.34 -5.76 -0.3 1.93e-8 Life satisfaction; CRC cis rs611744 0.647 rs1609472 chr8:109269232 T/G cg21045802 chr8:109455806 TTC35 0.42 6.63 0.34 1.34e-10 Dupuytren's disease; CRC cis rs7635838 0.859 rs9869423 chr3:11459156 G/T cg00170343 chr3:11313890 ATG7 0.41 6.24 0.33 1.35e-9 HDL cholesterol; CRC cis rs6564851 0.506 rs7186423 chr16:81257161 A/G cg05274606 chr16:81253692 PKD1L2 -0.36 -5.93 -0.31 7.65e-9 Carotenoid and tocopherol levels; CRC trans rs2303319 0.504 rs961421 chr2:162626099 G/C cg09481857 chr22:21368659 P2RX6;MGC16703 -0.64 -6.28 -0.33 1.08e-9 Cognitive function; CRC cis rs10464366 0.746 rs6945402 chr7:39145385 A/T cg15212455 chr7:39170539 POU6F2 0.46 6.05 0.32 3.99e-9 IgG glycosylation; CRC cis rs10924970 0.967 rs2185020 chr1:235440289 A/G cg26050004 chr1:235667680 B3GALNT2 0.4 6.01 0.31 4.84e-9 Asthma; CRC cis rs5769765 0.908 rs9616216 chr22:50318927 T/C cg02269571 chr22:50332266 NA -0.62 -7.82 -0.4 7.32e-14 Schizophrenia; CRC cis rs11997175 0.600 rs6468188 chr8:33639478 T/C ch.8.33884649F chr8:33765107 NA 0.41 6.41 0.33 5e-10 Body mass index; CRC cis rs9914988 0.887 rs12451790 chr17:27112000 C/G cg16670446 chr17:27188758 MIR451;MIR144 0.55 8.52 0.43 5.75e-16 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs501120 1.000 rs915083 chr10:44755406 T/G cg09554077 chr10:44749378 NA 0.89 13.32 0.59 1.14e-32 Coronary artery disease;Coronary heart disease; CRC cis rs6502050 0.799 rs9911129 chr17:80087819 C/T cg09264619 chr17:80180166 NA -0.36 -6.09 -0.32 3.09e-9 Life satisfaction; CRC trans rs3733585 0.648 rs35954357 chr4:9978758 G/C cg26043149 chr18:55253948 FECH 0.49 7.49 0.38 6.49e-13 Cleft plate (environmental tobacco smoke interaction); CRC cis rs7772486 0.875 rs2748490 chr6:146329681 G/T cg23711669 chr6:146136114 FBXO30 0.61 10.2 0.49 2.09e-21 Lobe attachment (rater-scored or self-reported); CRC cis rs7772486 0.743 rs9390344 chr6:146012755 C/G cg13319975 chr6:146136371 FBXO30 0.39 5.73 0.3 2.24e-8 Lobe attachment (rater-scored or self-reported); CRC cis rs3888647 0.561 rs4758617 chr11:2995185 T/A cg08508325 chr11:3079039 CARS -0.41 -7.44 -0.38 8.78e-13 Type 2 diabetes; CRC cis rs2806561 0.514 rs7519093 chr1:23541078 A/T cg24466277 chr1:23519622 HTR1D 0.42 5.81 0.31 1.47e-8 Height; CRC trans rs10504229 1.000 rs60454728 chr8:58173781 G/A cg04077850 chr5:125800366 GRAMD3 0.37 6.27 0.33 1.15e-9 Developmental language disorder (linguistic errors); CRC cis rs72781680 1.000 rs72788280 chr2:24095907 A/G cg08917208 chr2:24149416 ATAD2B 0.89 9.04 0.45 1.4e-17 Lymphocyte counts; CRC trans rs7027930 0.524 rs3812526 chr9:608703 A/G cg27061366 chr19:13044373 FARSA 0.53 6.66 0.34 1.18e-10 Pulmonary function decline; CRC trans rs11088226 0.681 rs9622 chr21:33951068 T/C cg09050820 chr6:167586206 TCP10L2 0.91 9.55 0.47 3.2e-19 Gastritis; CRC trans rs61931739 0.534 rs11053020 chr12:34111092 C/G cg26384229 chr12:38710491 ALG10B 0.53 6.9 0.36 2.71e-11 Morning vs. evening chronotype; CRC trans rs561341 1.000 rs4795670 chr17:30244839 T/C cg20587970 chr11:113659929 NA -0.96 -13.25 -0.59 2.05e-32 Hip circumference adjusted for BMI; CRC cis rs752010 0.806 rs943375 chr1:42092152 A/G cg06885757 chr1:42089581 HIVEP3 0.46 8.17 0.41 6.5e-15 Lupus nephritis in systemic lupus erythematosus; CRC cis rs12134245 0.776 rs12124682 chr1:91995542 A/G cg02896835 chr1:92012615 NA -0.65 -11.74 -0.54 8.01e-27 Breast cancer; CRC cis rs1975974 1.000 rs7224508 chr17:21722352 T/A cg18423549 chr17:21743878 NA -0.61 -8.63 -0.43 2.58e-16 Psoriasis; CRC cis rs559928 0.606 rs11600628 chr11:63976027 C/T cg19465662 chr11:63993652 NUDT22;TRPT1 0.7 6.72 0.35 7.9e-11 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; CRC cis rs887829 0.570 rs13015720 chr2:234600999 G/A cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.45 -7.06 -0.36 9.85e-12 Metabolic traits;Bilirubin levels;Cholelithiasis-related traits in sickle cell anemia;Metabolite levels;Total bilirubin levels in HIV-1 infection;Serum metabolite levels;Blood metabolite levels; CRC cis rs1941023 0.503 rs7944025 chr11:60142538 C/A cg08716584 chr11:60157161 MS4A7 -0.55 -9.03 -0.45 1.5e-17 Congenital heart disease (maternal effect); CRC cis rs2380220 0.720 rs9398251 chr6:95984709 C/T cg15832292 chr6:96025679 MANEA 0.61 6.81 0.35 4.62e-11 Behavioural disinhibition (generation interaction); CRC cis rs10504229 0.906 rs56138544 chr8:58184558 A/C cg24829409 chr8:58192753 C8orf71 -0.68 -11.34 -0.53 2.27e-25 Developmental language disorder (linguistic errors); CRC cis rs9660180 0.967 rs11260623 chr1:1781456 G/T cg17747265 chr1:1875780 NA -0.77 -13.36 -0.59 8.26e-33 Body mass index; CRC cis rs11212617 0.967 rs662578 chr11:108194557 C/T cg12106634 chr11:108092400 ATM;NPAT 0.43 6.37 0.33 6.45e-10 Response to metformin in type 2 diabetes (glycemic); CRC cis rs9611565 0.512 rs2050031 chr22:42152266 A/G cg17554472 chr22:41940697 POLR3H 0.56 5.71 0.3 2.55e-8 Vitiligo; CRC cis rs2070677 0.932 rs2987786 chr10:135365303 C/T cg16964102 chr10:135390573 NA 0.48 6.33 0.33 7.95e-10 Gout; CRC cis rs7769051 0.708 rs9483514 chr6:133228716 G/A cg07930552 chr6:133119739 C6orf192 0.57 6.79 0.35 5.28e-11 Type 2 diabetes nephropathy; CRC cis rs2882667 0.690 rs10515504 chr5:138222994 C/G cg09476006 chr5:138032270 NA -0.53 -9.05 -0.45 1.3e-17 Age-related hearing impairment (SNP x SNP interaction); CRC trans rs7395662 0.525 rs4882060 chr11:48441874 G/C cg03929089 chr4:120376271 NA -0.46 -6.62 -0.34 1.42e-10 HDL cholesterol; CRC cis rs4819052 0.851 rs2838839 chr21:46667858 C/G cg02159808 chr21:46707872 POFUT2;LOC642852 -0.5 -6.47 -0.34 3.55e-10 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs896854 0.654 rs6982393 chr8:95980708 T/C cg16049864 chr8:95962084 TP53INP1 -0.65 -11.91 -0.55 1.94e-27 Type 2 diabetes; CRC cis rs801193 1.000 rs2707854 chr7:66212597 G/A cg11764359 chr7:65958608 NA 0.54 8.25 0.41 3.77e-15 Aortic root size; CRC cis rs12681287 0.640 rs13253296 chr8:87448245 C/T cg27223183 chr8:87520930 FAM82B -0.52 -7.44 -0.38 8.7e-13 Caudate activity during reward; CRC cis rs1862618 0.853 rs832583 chr5:56178217 A/C cg12311346 chr5:56204834 C5orf35 -0.79 -10.04 -0.48 7.48e-21 Initial pursuit acceleration; CRC cis rs17270561 0.666 rs17320090 chr6:25720215 C/G cg17691542 chr6:26056736 HIST1H1C 0.64 8.22 0.41 4.62e-15 Iron status biomarkers; CRC cis rs6089584 0.507 rs6061989 chr20:60627893 C/T cg23463467 chr20:60627584 TAF4 0.44 8.31 0.42 2.47e-15 Body mass index; CRC cis rs7586879 0.681 rs6752483 chr2:25120086 C/T cg22495460 chr2:25135724 ADCY3 -0.87 -17.17 -0.69 1.23e-47 Body mass index; CRC cis rs6694672 0.867 rs4915327 chr1:197079130 T/C cg13682187 chr1:196946512 CFHR5 0.48 7.68 0.39 1.86e-13 Asthma; CRC cis rs2204008 0.744 rs11181635 chr12:38378420 C/T cg13010199 chr12:38710504 ALG10B 0.45 5.76 0.3 1.89e-8 Bladder cancer; CRC cis rs6867032 0.876 rs1552435 chr5:2018378 A/G cg26168224 chr5:2018326 NA 1.1 23.55 0.79 1.51e-72 Gut microbiome composition (winter); CRC cis rs9443645 0.901 rs2174739 chr6:79659170 C/T cg09184832 chr6:79620586 NA 0.5 9.19 0.45 4.44e-18 Intelligence (multi-trait analysis); CRC cis rs12477438 0.798 rs972768 chr2:99682397 G/C cg26064155 chr2:99771622 LIPT1;TSGA10 -0.79 -11.26 -0.53 4.44e-25 Chronic sinus infection; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg19056515 chr10:105361785 SH3PXD2A -0.41 -6.67 -0.35 1.07e-10 Liver disease severity in Alagille syndrome; CRC cis rs611744 0.647 rs689275 chr8:109241822 T/C cg21045802 chr8:109455806 TTC35 0.41 6.61 0.34 1.57e-10 Dupuytren's disease; CRC cis rs9322193 0.962 rs9478848 chr6:150146216 G/T cg13206674 chr6:150067644 NUP43 0.53 7.39 0.38 1.2e-12 Lung cancer; CRC cis rs6089584 0.854 rs2380146 chr20:60632233 C/T cg23463467 chr20:60627584 TAF4 0.35 6.08 0.32 3.4e-9 Body mass index; CRC cis rs9826463 0.757 rs73240318 chr3:142277427 A/G cg20824294 chr3:142316082 PLS1 0.42 6.99 0.36 1.54e-11 QRS duration in Tripanosoma cruzi seropositivity; CRC cis rs7811142 0.830 rs11771936 chr7:99943283 A/G cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.94 12.28 0.56 8.36e-29 Platelet count; CRC cis rs11764590 0.666 rs3996325 chr7:2053747 T/C cg25834613 chr7:1915315 MAD1L1 -0.37 -5.93 -0.31 7.48e-9 Neuroticism; CRC cis rs9894429 0.550 rs6565617 chr17:79612333 G/A cg09655341 chr17:79618100 PDE6G -0.35 -6.07 -0.32 3.5e-9 Eye color traits; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg19926395 chr7:150865207 GBX1 -0.36 -6.47 -0.34 3.47e-10 Myopia (pathological); CRC cis rs738322 0.934 rs133019 chr22:38573035 A/G cg25457927 chr22:38595422 NA -0.38 -7.89 -0.4 4.4e-14 Cutaneous nevi; CRC cis rs1552244 0.935 rs7649243 chr3:10089470 T/A cg02579736 chr3:10068473 FANCD2;CIDECP 1.02 13.77 0.6 2.25e-34 Alzheimer's disease; CRC trans rs11098499 0.754 rs9999724 chr4:120239944 C/T cg25214090 chr10:38739885 LOC399744 0.53 8.41 0.42 1.25e-15 Corneal astigmatism; CRC cis rs10911232 0.507 rs5022057 chr1:182997761 T/C ch.1.3577855R chr1:183094577 LAMC1 0.86 15.15 0.64 1.1e-39 Hypertriglyceridemia; CRC cis rs1223397 0.938 rs17700321 chr6:13280666 G/T cg06879394 chr6:13274151 PHACTR1 0.51 6.24 0.33 1.33e-9 Blood pressure; CRC cis rs4237845 0.611 rs4272820 chr12:58330541 G/A cg02175503 chr12:58329896 NA 0.71 10.86 0.51 1.07e-23 Intelligence (multi-trait analysis); CRC cis rs1816752 0.870 rs8000215 chr13:25009786 A/G cg02811702 chr13:24901961 NA 0.48 6.63 0.34 1.37e-10 Obesity-related traits; CRC cis rs9549367 0.789 rs2287253 chr13:113891075 G/A cg18105134 chr13:113819100 PROZ 0.68 10.29 0.49 1.05e-21 Platelet distribution width; CRC cis rs56176327 0.532 rs9849038 chr3:49771990 A/G cg03060546 chr3:49711283 APEH 0.66 8.29 0.42 3e-15 Intelligence (multi-trait analysis); CRC cis rs11098499 0.588 rs6534149 chr4:120559292 T/G cg24375607 chr4:120327624 NA -0.41 -6.42 -0.33 4.87e-10 Corneal astigmatism; CRC cis rs9937943 1.000 rs9937943 chr16:74499046 C/G cg01733217 chr16:74700730 RFWD3 0.66 7.55 0.38 4.21e-13 Neutrophil percentage of white cells; CRC cis rs736408 0.609 rs13061423 chr3:52790213 T/C cg15147215 chr3:52552868 STAB1 -0.62 -10.16 -0.49 2.85e-21 Bipolar disorder; CRC cis rs7580658 0.963 rs867304 chr2:128078488 G/A cg09760422 chr2:128146352 NA -0.36 -7.06 -0.36 1.01e-11 Protein C levels; CRC cis rs6951245 0.507 rs11976805 chr7:1138716 C/T cg26224354 chr7:1096374 C7orf50;GPR146 -0.53 -7.5 -0.38 5.96e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs12188164 0.965 rs72717438 chr5:448663 C/T cg26850624 chr5:429559 AHRR -0.81 -13.6 -0.6 9.63e-34 Cystic fibrosis severity; CRC cis rs7772486 0.658 rs6570706 chr6:145962922 T/C cg23711669 chr6:146136114 FBXO30 0.65 10.8 0.51 1.79e-23 Lobe attachment (rater-scored or self-reported); CRC cis rs875971 0.545 rs10950027 chr7:65634151 C/T cg02869306 chr7:64672164 INTS4L1 -0.43 -6.36 -0.33 6.91e-10 Aortic root size; CRC cis rs875971 0.825 rs28480509 chr7:66099224 A/G cg18876405 chr7:65276391 NA -0.53 -8.53 -0.43 5.29e-16 Aortic root size; CRC cis rs780094 0.544 rs780110 chr2:27685388 G/A cg21248554 chr2:27665150 KRTCAP3 -0.29 -6.63 -0.34 1.37e-10 Calcium levels;Fasting blood insulin;Metabolic traits;Triglyceride levels;Fasting plasma glucose;Urate levels in overweight individuals;Urate levels in obese individuals;Uric acid levels;Height;Age-related diseases, mortality and associated endophenotypes;Renal underexcretion gout;Fasting blood glucose (BMI interaction);Urate levels;Gondoic acid (20:1n-9) levels;Fasting blood insulin (BMI interaction);Triglycerides;Plasma omega-3 polyunsaturated fatty acid levels (docosapentaenoic acid);Type 2 diabetes;Nonalcoholic fatty liver disease;Hypertriglyceridemia;C-reactive protein;Age-related disease endophenotypes;LDL cholesterol;Metabolic syndrome;Crohn's disease;Alcohol consumption (drinks per week);Homeostasis model assessment of insulin resistance;Alcohol consumption;Red blood cell count;Fasting blood glucose; CRC cis rs2072499 0.750 rs55910626 chr1:156159909 C/G cg25208724 chr1:156163844 SLC25A44 1.01 16.24 0.67 5.64e-44 Testicular germ cell tumor; CRC cis rs7258465 0.965 rs7254249 chr19:18591745 G/A cg06953865 chr19:18549723 ISYNA1 -0.38 -5.81 -0.31 1.45e-8 Breast cancer; CRC cis rs6951245 0.745 rs79788515 chr7:1101079 C/T cg22907277 chr7:1156413 C7orf50 0.72 7.65 0.39 2.24e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs10751667 0.621 rs4075990 chr11:976614 T/C cg06064525 chr11:970664 AP2A2 -0.3 -6.11 -0.32 2.78e-9 Alzheimer's disease (late onset); CRC trans rs11231420 1 rs11231420 chr11:55644734 T/C cg25886479 chr11:50257625 LOC441601 0.38 6.31 0.33 8.8e-10 Pelvic organ prolapse (moderate/severe); CRC trans rs4295623 0.585 rs13259242 chr8:11593033 T/G cg27411982 chr8:10470053 RP1L1 -0.42 -6.62 -0.34 1.48e-10 Morning vs. evening chronotype; CRC cis rs796364 0.755 rs203762 chr2:200905136 C/A cg25936922 chr2:200820526 C2orf60;C2orf47 -0.7 -6.57 -0.34 2.02e-10 Schizophrenia; CRC cis rs769267 0.930 rs1063966 chr19:19616742 G/A cg03709012 chr19:19516395 GATAD2A 0.72 11.21 0.53 6.56e-25 Tonsillectomy; CRC cis rs9611565 0.592 rs4822046 chr22:41987543 G/A cg06634786 chr22:41940651 POLR3H -0.65 -6.95 -0.36 2e-11 Vitiligo; CRC cis rs7071206 0.898 rs28706743 chr10:79394329 T/G cg07817648 chr10:79422355 NA -0.74 -8.98 -0.44 2.08e-17 Bone mineral density; CRC cis rs1003719 0.762 rs8130846 chr21:38480242 G/A cg10648535 chr21:38446584 PIGP;TTC3 0.54 7.56 0.38 4.07e-13 Eye color traits; CRC cis rs10791323 0.569 rs2156680 chr11:133742292 T/G cg06766960 chr11:133703094 NA -0.35 -6.44 -0.33 4.29e-10 Childhood ear infection; CRC cis rs2839186 0.616 rs4819213 chr21:47619300 G/A cg12516959 chr21:47718080 NA 0.33 5.87 0.31 1.06e-8 Testicular germ cell tumor; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg13237906 chr5:149340052 SLC26A2 0.5 7.53 0.38 5.08e-13 Intelligence (multi-trait analysis); CRC cis rs4731207 0.698 rs6973812 chr7:124506750 T/C cg23710748 chr7:124431027 NA -0.38 -6.08 -0.32 3.42e-9 Cutaneous malignant melanoma; CRC cis rs7186908 0.711 rs9923344 chr16:72190653 T/C cg23815491 chr16:72088622 HP 0.64 8.21 0.41 5.02e-15 Liver enzyme levels (alkaline phosphatase); CRC cis rs12745968 0.589 rs4484938 chr1:92955821 T/C cg17283838 chr1:93427260 FAM69A -0.43 -5.98 -0.31 5.73e-9 Bipolar disorder and schizophrenia; CRC trans rs10411161 0.702 rs7247017 chr19:52391769 T/C cg22319618 chr22:45562946 NUP50 -0.58 -6.01 -0.31 4.92e-9 Breast cancer; CRC trans rs2840044 1.000 rs225259 chr17:33958168 A/G cg19694781 chr19:47549865 TMEM160 -0.46 -7.27 -0.37 2.72e-12 Response to radiotherapy in cancer (late toxicity); CRC cis rs3018066 0.836 rs28784652 chr4:107025576 A/G cg01869342 chr4:106983673 TBCK 0.36 5.67 0.3 3.17e-8 Cancer; CRC cis rs477895 0.652 rs72920332 chr11:63947071 G/T cg23719950 chr11:63933701 MACROD1 -0.66 -8.39 -0.42 1.5e-15 Mean platelet volume; CRC cis rs2933343 0.729 rs813732 chr3:128619357 C/T cg11901034 chr3:128598214 ACAD9 -0.55 -7.69 -0.39 1.74e-13 IgG glycosylation; CRC trans rs12517041 1.000 rs10941982 chr5:23298902 A/C ch.8.1293020R chr8:59333349 UBXN2B -0.55 -6.17 -0.32 2.05e-9 Calcium levels; CRC cis rs6952808 0.636 rs73048162 chr7:1949328 T/C cg04267008 chr7:1944627 MAD1L1 -0.64 -9.82 -0.48 4.02e-20 Bipolar disorder and schizophrenia; CRC cis rs34311866 0.808 rs11248059 chr4:960331 C/G cg07828340 chr4:882639 GAK 1.09 10.16 0.49 2.9e-21 Parkinson's disease; CRC cis rs7408868 1.000 rs1548554 chr19:15277938 C/T cg14696996 chr19:15285081 NOTCH3 0.96 9.0 0.44 1.82e-17 Pulse pressure; CRC cis rs9914988 0.725 rs9905510 chr17:27092325 G/A cg12682573 chr17:27188876 MIR451;MIR144 0.58 7.98 0.4 2.43e-14 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs9368481 0.761 rs9357030 chr6:26985026 G/T cg06675483 chr6:26987649 LOC100270746;C6orf41 -0.41 -5.73 -0.3 2.23e-8 Autism spectrum disorder or schizophrenia; CRC cis rs2795502 0.766 rs947549 chr10:43265880 G/C cg20628663 chr10:43360327 NA -0.66 -8.15 -0.41 7.56e-15 Blood protein levels; CRC cis rs73206853 0.688 rs73191809 chr12:110907639 T/A cg12870014 chr12:110450643 ANKRD13A 0.77 7.34 0.38 1.69e-12 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC cis rs1448094 0.511 rs11117023 chr12:86145329 G/A cg18827107 chr12:86230957 RASSF9 0.39 5.96 0.31 6.52e-9 Major depressive disorder; CRC cis rs938554 0.570 rs7696983 chr4:9995829 A/C cg11266682 chr4:10021025 SLC2A9 0.41 6.42 0.33 4.9e-10 Blood metabolite levels; CRC cis rs17401966 1.000 rs11578788 chr1:10422958 A/G cg19773385 chr1:10388646 KIF1B -0.56 -7.55 -0.38 4.46e-13 Hepatocellular carcinoma; CRC trans rs7647973 0.710 rs9869120 chr3:49624065 T/C cg21665057 chr3:196295764 WDR53;FBXO45 -0.67 -6.94 -0.36 2.13e-11 Menarche (age at onset); CRC cis rs6681460 1.000 rs1536115 chr1:67121001 A/T cg02459107 chr1:67143332 SGIP1 0.48 8.19 0.41 5.83e-15 Presence of antiphospholipid antibodies; CRC trans rs801193 0.901 rs4273746 chr7:66301111 C/T cg18876405 chr7:65276391 NA -0.56 -9.36 -0.46 1.3e-18 Aortic root size; CRC cis rs514406 0.621 rs2003250 chr1:53196666 T/C cg24675658 chr1:53192096 ZYG11B 0.68 10.55 0.5 1.36e-22 Monocyte count; CRC trans rs4263408 0.934 rs9683743 chr4:39703194 A/C cg16746620 chr16:89178589 ACSF3 -0.39 -6.08 -0.32 3.31e-9 Plasma amyloid beta peptide concentrations (ABx-40); CRC cis rs28374715 0.662 rs28827035 chr15:41492290 G/A cg18705301 chr15:41695430 NDUFAF1 -0.92 -13.71 -0.6 3.67e-34 Ulcerative colitis; CRC trans rs1814175 0.676 rs11040647 chr11:49935947 A/C cg15704280 chr7:45808275 SEPT13 -0.95 -16.82 -0.68 3.11e-46 Height; CRC cis rs13108904 0.521 rs4974609 chr4:1356924 A/C cg00684032 chr4:1343700 KIAA1530 -0.42 -6.34 -0.33 7.66e-10 Obesity-related traits; CRC cis rs6570726 0.791 rs414600 chr6:145879606 G/A cg23711669 chr6:146136114 FBXO30 0.77 13.46 0.6 3.42e-33 Lobe attachment (rater-scored or self-reported); CRC trans rs17685 0.753 rs10264760 chr7:75749694 A/G cg19862616 chr7:65841803 NCRNA00174 0.98 17.88 0.7 1.96e-50 Coffee consumption;Coffee consumption (cups per day); CRC cis rs2251381 0.750 rs2776250 chr21:30528094 T/G cg24692254 chr21:30365293 RNF160 0.75 12.49 0.57 1.48e-29 Selective IgA deficiency; CRC cis rs8031584 0.918 rs35784593 chr15:31254588 G/A cg08704250 chr15:31115839 NA -0.45 -8.28 -0.42 3.16e-15 Huntington's disease progression; CRC cis rs13108904 0.560 rs11247994 chr4:1343720 G/A cg20092199 chr4:1342459 KIAA1530 0.47 7.65 0.39 2.24e-13 Obesity-related traits; CRC cis rs728616 0.867 rs3088308 chr10:81697868 A/T cg11900509 chr10:81946545 ANXA11 -0.65 -6.71 -0.35 8.77e-11 Chronic obstructive pulmonary disease-related biomarkers; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg00428944 chr8:101963525 YWHAZ 0.39 6.25 0.33 1.25e-9 Liver disease severity in Alagille syndrome; CRC cis rs9462027 0.606 rs4513788 chr6:34694779 C/T cg07306190 chr6:34760872 UHRF1BP1 -0.34 -6.07 -0.32 3.49e-9 Systemic lupus erythematosus; CRC cis rs10504229 0.775 rs56155911 chr8:58163247 C/T cg02290350 chr8:58132656 NA -0.5 -6.18 -0.32 1.95e-9 Developmental language disorder (linguistic errors); CRC cis rs1003719 0.788 rs2835586 chr21:38461326 G/A cg10648535 chr21:38446584 PIGP;TTC3 0.52 7.34 0.38 1.66e-12 Eye color traits; CRC cis rs12044355 0.929 rs11122322 chr1:231843962 G/T cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.43 -6.27 -0.33 1.16e-9 Alzheimer's disease; CRC cis rs5760092 0.755 rs915589 chr22:24261004 C/T cg04234412 chr22:24373322 LOC391322 0.64 7.04 0.36 1.1e-11 Urinary 1,3-butadiene metabolite levels in smokers; CRC cis rs9649213 0.531 rs35216698 chr7:97896175 C/T cg24562669 chr7:97807699 LMTK2 0.48 8.04 0.41 1.69e-14 Prostate cancer (SNP x SNP interaction); CRC cis rs6088580 0.634 rs1205338 chr20:32925625 C/G cg24642439 chr20:33292090 TP53INP2 -0.41 -6.79 -0.35 5.24e-11 Glomerular filtration rate (creatinine); CRC cis rs4319547 0.915 rs11058402 chr12:122981053 A/G cg05707623 chr12:122985044 ZCCHC8 -0.81 -10.15 -0.49 3.13e-21 Body mass index; CRC cis rs6662572 1.000 rs1053941 chr1:46084383 G/T cg08644498 chr1:46502608 NA 0.44 6.38 0.33 6.07e-10 Blood protein levels; CRC cis rs11123610 0.520 rs12996655 chr2:3720900 G/A cg00999904 chr2:3704751 ALLC -0.53 -6.66 -0.34 1.15e-10 Response to inhaled corticosteroid treatment in asthma (change in FEV1); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg23391157 chr5:43313644 HMGCS1 0.43 6.02 0.31 4.73e-9 Response to antipsychotic treatment; CRC trans rs1814175 0.527 rs7128827 chr11:49665644 C/T cg11707556 chr5:10655725 ANKRD33B 0.43 7.06 0.36 9.88e-12 Height; CRC cis rs6951245 1.000 rs113066613 chr7:1094128 T/C cg03188948 chr7:1209495 NA 0.66 6.96 0.36 1.9e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs1059312 0.808 rs10847694 chr12:129292457 C/A cg21616243 chr12:129299702 MGC16384;SLC15A4 -0.75 -13.31 -0.59 1.24e-32 Systemic lupus erythematosus; CRC cis rs7647973 0.710 rs9869120 chr3:49624065 T/C cg13072238 chr3:49761600 GMPPB -0.54 -5.85 -0.31 1.19e-8 Menarche (age at onset); CRC cis rs6860806 0.507 rs2631362 chr5:131707293 A/G cg02033258 chr5:131593261 PDLIM4 -0.37 -6.21 -0.32 1.59e-9 Breast cancer; CRC cis rs7725052 0.609 rs10052696 chr5:40450762 C/T cg09067459 chr5:40385259 NA -0.4 -6.61 -0.34 1.53e-10 Pediatric autoimmune diseases; CRC cis rs2032447 0.966 rs9358901 chr6:26024436 G/T cg03264133 chr6:25882463 NA -0.42 -5.89 -0.31 9.38e-9 Intelligence (multi-trait analysis); CRC cis rs2549003 0.966 rs2706385 chr5:131831766 T/G cg00255919 chr5:131827918 IRF1 -0.61 -12.04 -0.55 6.4e-28 Asthma (sex interaction); CRC cis rs1348850 0.914 rs1374437 chr2:178363423 T/C cg22681709 chr2:178499509 PDE11A -0.4 -7.44 -0.38 9.14e-13 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs2814982 0.543 rs75776386 chr6:34465215 G/A cg14254433 chr6:34482411 PACSIN1 -0.81 -8.65 -0.43 2.28e-16 Cholesterol, total;Total cholesterol levels; CRC cis rs9311676 0.632 rs11130630 chr3:58360800 A/G cg06643156 chr3:58380774 PXK 0.43 6.73 0.35 7.6e-11 Systemic lupus erythematosus; CRC trans rs7819412 0.540 rs11777355 chr8:11044689 A/G cg16141378 chr3:129829833 LOC729375 0.42 6.15 0.32 2.28e-9 Triglycerides; CRC cis rs9467160 1.000 rs9461012 chr6:24441844 A/G cg20631270 chr6:24437470 GPLD1 -0.47 -6.24 -0.33 1.38e-9 Liver enzyme levels; CRC trans rs2727020 0.595 rs10839281 chr11:49483373 A/C cg03929089 chr4:120376271 NA -0.92 -17.24 -0.69 6.51e-48 Coronary artery disease; CRC cis rs2243480 1.000 rs1796228 chr7:66033084 G/A cg25985355 chr7:65971099 NA -0.52 -5.96 -0.31 6.41e-9 Diabetic kidney disease; CRC cis rs870825 0.616 rs10022818 chr4:185619282 A/G cg04058563 chr4:185651563 MLF1IP 0.72 9.47 0.46 5.62e-19 Blood protein levels; CRC cis rs13256369 0.802 rs1060106 chr8:8561452 A/G cg17143192 chr8:8559678 CLDN23 0.5 6.44 0.33 4.22e-10 Obesity-related traits; CRC cis rs6918586 0.658 rs198856 chr6:26102708 G/A cg18357526 chr6:26021779 HIST1H4A -0.49 -7.4 -0.38 1.16e-12 Schizophrenia; CRC cis rs832540 0.898 rs2662024 chr5:56257515 T/C cg18230493 chr5:56204884 C5orf35 0.4 6.07 0.32 3.55e-9 Coronary artery disease; CRC cis rs7927771 1.000 rs7927771 chr11:47781306 A/G cg05585544 chr11:47624801 NA -0.62 -10.82 -0.51 1.47e-23 Subjective well-being; CRC cis rs7618915 0.547 rs2268026 chr3:52778347 T/C cg10802521 chr3:52805072 NEK4 -0.59 -8.98 -0.44 2.07e-17 Bipolar disorder; CRC cis rs9303401 0.659 rs34878689 chr17:56694330 G/A cg02118635 chr17:56770003 RAD51C;TEX14 0.82 9.69 0.47 1.07e-19 Cognitive test performance; CRC cis rs17711722 0.528 rs73138179 chr7:65294482 G/T cg05627663 chr7:65219948 SNORA22;CCT6P1 0.67 10.07 0.49 5.81e-21 Calcium levels; CRC cis rs12220238 1.000 rs111704178 chr10:75957251 G/A cg19889307 chr10:75911429 ADK;AP3M1 0.54 5.61 0.3 4.26e-8 Soluble interleukin-2 receptor subunit alpha; CRC cis rs6088590 1.000 rs11696546 chr20:33452999 C/G cg24642439 chr20:33292090 TP53INP2 0.51 8.78 0.44 9.02e-17 Coronary artery disease; CRC cis rs6908034 0.607 rs114146042 chr6:19807229 G/A cg02682789 chr6:19804855 NA 0.78 6.7 0.35 9.11e-11 Endometriosis;Deep ovarian and/or rectovaginal disease with dense adhesions; CRC cis rs2075371 1.000 rs2244700 chr7:133987374 A/G cg20476274 chr7:133979776 SLC35B4 0.78 13.99 0.61 3.27e-35 Mean platelet volume; CRC cis rs2688608 0.618 rs28718766 chr10:75489844 C/A cg16540259 chr10:75572220 NDST2 0.39 5.96 0.31 6.52e-9 Inflammatory bowel disease; CRC cis rs929354 0.557 rs62491947 chr7:156960813 G/A cg16102536 chr7:156981717 UBE3C 0.39 6.51 0.34 2.81e-10 Body mass index; CRC cis rs9309711 0.643 rs10188449 chr2:3480366 T/C cg15541040 chr2:3486749 NA -0.53 -8.58 -0.43 3.82e-16 Neurofibrillary tangles; CRC cis rs4819052 0.851 rs2236446 chr21:46678985 T/C cg02159808 chr21:46707872 POFUT2;LOC642852 0.51 6.91 0.36 2.51e-11 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs354225 0.586 rs966003 chr2:54884870 C/T cg26097391 chr2:54893211 SPTBN1 0.52 8.84 0.44 6.07e-17 Schizophrenia; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg00742472 chr14:31889912 NA 0.42 6.67 0.35 1.11e-10 Liver disease severity in Alagille syndrome; CRC cis rs875971 0.617 rs810400 chr7:66022889 G/C cg00343986 chr7:65444356 GUSB -0.49 -7.42 -0.38 1e-12 Aortic root size; CRC cis rs1008375 0.686 rs34338142 chr4:17626174 T/A cg02297831 chr4:17616191 MED28 0.46 6.05 0.32 3.9e-9 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs7811142 0.887 rs4074838 chr7:100032665 G/A cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.74 10.11 0.49 4.15e-21 Platelet count; CRC cis rs13108904 0.967 rs11727167 chr4:1285521 A/G cg19318889 chr4:1322082 MAEA 0.4 5.66 0.3 3.25e-8 Obesity-related traits; CRC cis rs757110 0.526 rs757081 chr11:17351683 C/G cg15432903 chr11:17409602 KCNJ11 -0.57 -7.25 -0.37 3.01e-12 Type 2 diabetes; CRC cis rs6502050 0.835 rs7406220 chr17:80077850 T/C cg02741985 chr17:80059408 CCDC57 -0.44 -7.17 -0.37 4.96e-12 Life satisfaction; CRC cis rs3617 0.625 rs7612624 chr3:52893426 T/C cg15147215 chr3:52552868 STAB1 0.53 9.13 0.45 7.14e-18 Red blood cell count;Autism spectrum disorder or schizophrenia; CRC cis rs2070488 0.804 rs1817364 chr3:38474513 T/G cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.79 13.72 0.6 3.52e-34 Electrocardiographic conduction measures; CRC cis rs59104589 0.617 rs16842449 chr2:242354979 C/T cg19488206 chr2:242435732 STK25 0.46 6.31 0.33 8.92e-10 Fibrinogen levels; CRC cis rs7223966 1.000 rs61360320 chr17:61800392 C/T cg23090583 chr17:61904693 PSMC5;FTSJ3 0.5 6.18 0.32 1.89e-9 Hip circumference adjusted for BMI;Body mass index; CRC cis rs7113874 0.589 rs10840051 chr11:8475180 G/C cg17679104 chr11:8615758 STK33 -0.34 -5.67 -0.3 3.06e-8 Body mass index in physically active individuals;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs13118159 0.527 rs1250119 chr4:1261336 G/A cg21620606 chr4:1342894 KIAA1530 -0.39 -6.01 -0.31 5.04e-9 Longevity; CRC cis rs2062225 1.000 rs11685628 chr2:111769226 A/G cg11729679 chr2:111877065 BCL2L11 -0.56 -5.62 -0.3 4.08e-8 Monocyte count; CRC cis rs72772090 0.539 rs17481759 chr5:96114695 A/G cg17330273 chr5:96107758 CAST;ERAP1 -0.69 -6.38 -0.33 5.89e-10 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs11764590 0.724 rs62444917 chr7:2107262 A/C cg14004847 chr7:1930337 MAD1L1 -0.45 -5.8 -0.3 1.55e-8 Neuroticism; CRC cis rs7659604 1.000 rs28640980 chr4:122664284 T/C cg06713675 chr4:122721982 EXOSC9 -0.37 -6.14 -0.32 2.39e-9 Type 2 diabetes; CRC cis rs3736594 0.918 rs12471347 chr2:27981655 G/C cg27432699 chr2:27873401 GPN1 0.57 7.37 0.38 1.37e-12 Fasting blood glucose;Fasting blood glucose (BMI interaction); CRC trans rs10435719 0.902 rs7006538 chr8:11804982 A/G cg06636001 chr8:8085503 FLJ10661 0.5 7.63 0.39 2.61e-13 C-reactive protein levels or triglyceride levels (pleiotropy); CRC cis rs798554 0.757 rs1182171 chr7:2878510 A/G cg17321639 chr7:2759063 NA -0.52 -7.04 -0.36 1.15e-11 Height; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg08109571 chr12:113573586 RASAL1 0.43 6.28 0.33 1.08e-9 Intelligence (multi-trait analysis); CRC cis rs7626444 0.625 rs1104375 chr3:196476043 C/G cg12930392 chr3:196481615 PAK2 0.41 7.29 0.37 2.3e-12 Monocyte count; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg11936145 chr3:142297737 ATR 0.38 6.1 0.32 3.03e-9 Liver disease severity in Alagille syndrome; CRC cis rs453301 0.507 rs2929306 chr8:9084909 C/T cg06636001 chr8:8085503 FLJ10661 -0.56 -8.86 -0.44 5.2e-17 Joint mobility (Beighton score); CRC cis rs7937682 0.883 rs472465 chr11:111468962 C/T cg19812747 chr11:111475976 SIK2 -0.57 -9.72 -0.47 8.51e-20 Primary sclerosing cholangitis; CRC trans rs561341 1.000 rs8077092 chr17:30281992 T/C cg27661571 chr11:113659931 NA -0.78 -9.69 -0.47 1.08e-19 Hip circumference adjusted for BMI; CRC cis rs6835098 1.000 rs6826412 chr4:174109622 C/T cg08422745 chr4:174089978 GALNT7 -0.95 -15.04 -0.64 2.78e-39 Dementia and core Alzheimer's disease neuropathologic changes; CRC cis rs2075371 0.829 rs35897155 chr7:134002711 G/A cg11752832 chr7:134001865 SLC35B4 0.43 6.23 0.32 1.45e-9 Mean platelet volume; CRC cis rs10479542 0.784 rs6896940 chr5:178985994 G/C cg19626725 chr5:178986131 RUFY1 0.38 7.76 0.39 1.06e-13 Lung cancer; CRC cis rs10256972 0.552 rs2960830 chr7:1200641 T/C cg03923535 chr7:1197113 ZFAND2A 0.71 10.63 0.51 7.07e-23 Longevity;Endometriosis; CRC cis rs1799949 1.000 rs2298862 chr17:41176688 T/C cg25072359 chr17:41440525 NA 0.47 6.91 0.36 2.53e-11 Menopause (age at onset); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg11126068 chr11:67195806 RPS6KB2 0.45 6.21 0.32 1.64e-9 Response to antipsychotic treatment; CRC cis rs6952808 0.630 rs10239050 chr7:2158390 A/G cg21782813 chr7:2030301 MAD1L1 0.49 8.62 0.43 2.89e-16 Bipolar disorder and schizophrenia; CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg22776125 chr6:167041314 RPS6KA2 -0.62 -7.81 -0.4 7.73e-14 Diisocyanate-induced asthma; CRC cis rs4969178 0.965 rs12451715 chr17:76397334 A/C cg20026190 chr17:76395443 PGS1 0.4 6.2 0.32 1.73e-9 HDL cholesterol levels; CRC cis rs7712401 0.755 rs10900759 chr5:122105080 T/A cg18764291 chr5:122110994 SNX2 0.37 5.89 0.31 9.33e-9 Mean platelet volume; CRC cis rs4728302 0.838 rs10225454 chr7:133591535 G/C cg10665199 chr7:133106180 EXOC4 0.39 5.84 0.31 1.25e-8 Intelligence;Intelligence (multi-trait analysis); CRC cis rs4588572 0.643 rs6453391 chr5:77755035 T/C cg11547950 chr5:77652471 NA -0.52 -7.03 -0.36 1.16e-11 Triglycerides; CRC cis rs365302 1.000 rs411814 chr6:159644843 G/A cg14500486 chr6:159655392 FNDC1 0.43 6.59 0.34 1.77e-10 Coronary heart disease; CRC cis rs9902453 1.000 rs4328498 chr17:28344276 G/A cg26525008 chr17:28256777 EFCAB5;SSH2 -0.58 -8.65 -0.43 2.31e-16 Coffee consumption (cups per day); CRC cis rs4713118 0.955 rs9393847 chr6:27687973 G/A cg15786705 chr6:28176104 NA 0.51 6.67 0.35 1.06e-10 Parkinson's disease; CRC trans rs5756813 0.688 rs12484134 chr22:38126728 T/C cg19894588 chr14:64061835 NA -0.59 -7.72 -0.39 1.37e-13 Optic cup area;Vertical cup-disc ratio; CRC cis rs2302729 0.860 rs6489375 chr12:2777768 A/G cg19945202 chr12:2788847 CACNA1C -0.39 -5.73 -0.3 2.24e-8 Sleep quality; CRC cis rs28386778 0.863 rs6919 chr17:61909485 A/T cg25654072 chr17:61904446 PSMC5;FTSJ3 -0.66 -10.09 -0.49 4.82e-21 Prudent dietary pattern; CRC cis rs60871478 0.786 rs12532534 chr7:831891 G/A cg13844804 chr7:814759 HEATR2 -0.65 -7.38 -0.38 1.28e-12 Cerebrospinal P-tau181p levels; CRC cis rs4654899 1.000 rs6682368 chr1:21506914 G/A cg02927042 chr1:21476669 EIF4G3 -0.48 -7.58 -0.39 3.62e-13 Superior frontal gyrus grey matter volume; CRC cis rs9660180 1.000 rs9660180 chr1:1723031 G/A cg05132306 chr1:1846340 CALML6 -0.44 -6.78 -0.35 5.63e-11 Body mass index; CRC cis rs713477 0.967 rs6573031 chr14:55913763 C/G cg21836586 chr14:55907198 TBPL2 0.3 5.6 0.3 4.51e-8 Pediatric bone mineral content (femoral neck); CRC cis rs11249608 0.548 rs6880315 chr5:178452502 G/A cg01312482 chr5:178451176 ZNF879 -0.36 -5.97 -0.31 6.04e-9 Pubertal anthropometrics; CRC trans rs1814175 0.645 rs11040702 chr11:50024827 C/T cg03929089 chr4:120376271 NA -0.88 -15.84 -0.66 2.09e-42 Height; CRC cis rs1532331 0.768 rs6884303 chr5:43152799 T/C cg09164108 chr5:43007320 NA 0.38 5.82 0.31 1.43e-8 Menarche (age at onset); CRC cis rs6938 0.596 rs11630918 chr15:75155896 C/T cg18612461 chr15:75251733 NA 0.38 5.86 0.31 1.1e-8 Breast cancer; CRC cis rs6088590 0.502 rs6059861 chr20:33068563 A/T cg24642439 chr20:33292090 TP53INP2 0.37 6.23 0.32 1.43e-9 Coronary artery disease; CRC cis rs739401 0.611 rs2301140 chr11:3022629 C/T cg08508325 chr11:3079039 CARS -0.46 -7.8 -0.4 8.18e-14 Longevity; CRC cis rs3806843 0.576 rs155358 chr5:140297032 A/T cg19875535 chr5:140030758 IK 0.44 6.76 0.35 6.44e-11 Depressive symptoms (multi-trait analysis); CRC cis rs6684514 1.000 rs10908500 chr1:156280671 A/T cg16558208 chr1:156270281 VHLL 0.55 8.61 0.43 2.99e-16 Mean corpuscular hemoglobin concentration;Glycated hemoglobin levels; CRC cis rs4319547 0.656 rs7397299 chr12:122821649 G/T cg05707623 chr12:122985044 ZCCHC8 -0.57 -7.04 -0.36 1.13e-11 Body mass index; CRC cis rs875971 0.862 rs1167408 chr7:65556108 G/A cg11764359 chr7:65958608 NA -0.58 -8.83 -0.44 6.38e-17 Aortic root size; CRC trans rs11098499 0.954 rs6847248 chr4:120225955 A/G cg25214090 chr10:38739885 LOC399744 0.55 7.91 0.4 3.97e-14 Corneal astigmatism; CRC cis rs1552244 0.832 rs115415687 chr3:10195704 C/T cg02579736 chr3:10068473 FANCD2;CIDECP 1.0 11.16 0.52 1.01e-24 Alzheimer's disease; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg03664139 chr6:101329504 ASCC3 0.48 6.19 0.32 1.78e-9 Thyroid stimulating hormone; CRC cis rs6860806 0.507 rs270608 chr5:131648406 C/T cg22638593 chr5:131593259 PDLIM4 0.42 6.78 0.35 5.43e-11 Breast cancer; CRC cis rs8044868 0.530 rs2287998 chr16:72059269 C/T cg23815491 chr16:72088622 HP -0.46 -6.72 -0.35 8.08e-11 Body mass index (change over time) in cancer or chronic obstructive pulmonary disease;Body mass index (change over time) in cancer; CRC cis rs9549328 0.670 rs35992827 chr13:113616752 G/A cg25790453 chr13:113633590 MCF2L 0.41 7.21 0.37 3.79e-12 Systolic blood pressure; CRC cis rs1448094 0.511 rs34656916 chr12:86154658 G/C cg02569458 chr12:86230093 RASSF9 0.51 8.43 0.42 1.13e-15 Major depressive disorder; CRC cis rs2836950 0.501 rs11088470 chr21:40689162 A/G cg17971929 chr21:40555470 PSMG1 -0.52 -7.38 -0.38 1.34e-12 Menarche (age at onset); CRC cis rs597539 0.652 rs673821 chr11:68678718 G/T cg06112835 chr11:68658793 MRPL21 0.47 7.58 0.39 3.45e-13 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs11122272 0.735 rs2486745 chr1:231505717 T/C cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.54 -8.11 -0.41 1.04e-14 Hemoglobin concentration; CRC cis rs6500395 1.000 rs2111243 chr16:48724897 C/T cg04672837 chr16:48644449 N4BP1 -0.45 -6.63 -0.34 1.38e-10 Response to tocilizumab in rheumatoid arthritis; CRC trans rs2727020 0.521 rs7131163 chr11:49574774 C/T cg11707556 chr5:10655725 ANKRD33B -0.48 -7.69 -0.39 1.71e-13 Coronary artery disease; CRC cis rs35146811 0.586 rs6946168 chr7:99598286 C/T cg13334819 chr7:99746414 C7orf59 -0.47 -6.34 -0.33 7.51e-10 Coronary artery disease; CRC cis rs10791323 0.628 rs1893850 chr11:133705356 T/C cg03690763 chr11:133734501 NA -0.34 -5.73 -0.3 2.33e-8 Childhood ear infection; CRC cis rs9747201 1.000 rs12451470 chr17:80177532 G/A cg14673194 chr17:80132900 CCDC57 -0.48 -6.13 -0.32 2.48e-9 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs9303401 1.000 rs9303401 chr17:56847945 C/T cg02118635 chr17:56770003 RAD51C;TEX14 0.55 8.16 0.41 6.95e-15 Cognitive test performance; CRC cis rs2274273 0.967 rs2094102 chr14:55591098 T/C cg23234261 chr14:55582407 NA -0.29 -5.82 -0.31 1.42e-8 Protein biomarker; CRC cis rs11105298 0.891 rs10858854 chr12:89835728 C/A cg08166232 chr12:89918718 WDR51B;GALNT4 -0.58 -7.1 -0.36 7.78e-12 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; CRC cis rs6973256 0.897 rs7776986 chr7:133345635 A/G cg10665199 chr7:133106180 EXOC4 -0.37 -5.89 -0.31 9.51e-9 Intelligence (multi-trait analysis); CRC trans rs2403907 0.758 rs7275695 chr21:16568524 C/T cg00407105 chr4:90231041 NA -0.39 -6.13 -0.32 2.56e-9 Breast cancer; CRC cis rs2197308 0.692 rs67352173 chr12:37906912 A/T cg13010199 chr12:38710504 ALG10B 0.45 5.99 0.31 5.52e-9 Morning vs. evening chronotype; CRC cis rs736408 0.812 rs2071506 chr3:52826276 T/C cg08222913 chr3:52553049 STAB1 -0.34 -5.99 -0.31 5.5e-9 Bipolar disorder; CRC trans rs9291683 0.632 rs13101785 chr4:10042915 T/A cg26043149 chr18:55253948 FECH 0.53 8.17 0.41 6.72e-15 Bone mineral density; CRC cis rs9322193 0.962 rs9689447 chr6:150110486 T/A cg00933542 chr6:150070202 PCMT1 0.28 5.63 0.3 3.86e-8 Lung cancer; CRC trans rs7824557 0.591 rs2736283 chr8:11225910 A/G cg06636001 chr8:8085503 FLJ10661 -0.45 -6.69 -0.35 9.75e-11 Retinal vascular caliber; CRC cis rs9733 0.596 rs11586422 chr1:150679358 C/T cg15448220 chr1:150897856 SETDB1 0.45 6.41 0.33 5.09e-10 Tonsillectomy; CRC cis rs77956314 0.515 rs10850733 chr12:117380961 G/A cg02017074 chr12:117425053 FBXW8 0.63 8.01 0.4 2.05e-14 Subcortical brain region volumes;Hippocampal volume; CRC cis rs7552404 1.000 rs72686191 chr1:76218319 G/T cg10523679 chr1:76189770 ACADM 0.85 11.58 0.54 2.93e-26 Blood metabolite levels;Acylcarnitine levels; CRC cis rs9914988 0.725 rs9905510 chr17:27092325 G/A cg16670446 chr17:27188758 MIR451;MIR144 0.55 8.55 0.43 4.83e-16 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg19855366 chr13:111267979 CARKD 0.4 6.44 0.33 4.21e-10 Obesity-related traits; CRC cis rs561341 0.941 rs7215147 chr17:30266711 G/A cg19193384 chr17:30244184 NA -0.49 -6.73 -0.35 7.42e-11 Hip circumference adjusted for BMI; CRC cis rs6951245 0.744 rs1133122 chr7:1192572 C/A cg26224354 chr7:1096374 C7orf50;GPR146 -0.81 -10.62 -0.51 7.84e-23 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs7666738 0.716 rs9994641 chr4:99101605 C/T cg05340658 chr4:99064831 C4orf37 0.51 7.62 0.39 2.65e-13 Colonoscopy-negative controls vs population controls; CRC cis rs992157 0.560 rs6436048 chr2:219109033 C/T cg04880052 chr2:219191631 PNKD 0.41 6.72 0.35 8e-11 Colorectal cancer; CRC cis rs728616 0.681 rs12412762 chr10:81907470 A/G cg05935833 chr10:81318306 SFTPA2 0.51 5.86 0.31 1.1e-8 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs10504229 1.000 rs75037501 chr8:58170136 T/G cg02725872 chr8:58115012 NA -0.38 -6.43 -0.33 4.44e-10 Developmental language disorder (linguistic errors); CRC cis rs950169 0.580 rs36126054 chr15:85177723 T/G cg11189052 chr15:85197271 WDR73 0.65 9.36 0.46 1.25e-18 Schizophrenia; CRC cis rs3768617 0.510 rs4651140 chr1:183096952 G/T ch.1.3577855R chr1:183094577 LAMC1 0.89 15.86 0.66 1.84e-42 Fuchs's corneal dystrophy; CRC cis rs524281 0.861 rs9645684 chr11:65907964 G/A cg14036092 chr11:66035641 RAB1B -0.46 -5.65 -0.3 3.43e-8 Electroencephalogram traits; CRC cis rs12142240 0.698 rs66847432 chr1:46832013 G/A cg14993813 chr1:46806288 NSUN4 -0.49 -6.26 -0.33 1.21e-9 Menopause (age at onset); CRC cis rs4132509 1.000 rs12403316 chr1:243956903 C/T cg21452805 chr1:244014465 NA 0.54 7.23 0.37 3.35e-12 RR interval (heart rate); CRC cis rs853679 0.567 rs13196606 chr6:28370078 C/T cg21251018 chr6:28226885 NKAPL 0.38 5.69 0.3 2.87e-8 Depression; CRC cis rs853679 0.550 rs34477097 chr6:28197186 C/T cg15786705 chr6:28176104 NA 0.64 8.45 0.42 9.45e-16 Depression; CRC cis rs2836974 0.897 rs2836928 chr21:40543320 C/T cg06238570 chr21:40685208 BRWD1 0.74 10.12 0.49 3.94e-21 Cognitive function; CRC cis rs6502050 0.835 rs3935128 chr17:80113414 T/C cg25804541 chr17:80189381 SLC16A3 -0.31 -5.97 -0.31 6.08e-9 Life satisfaction; CRC cis rs4665809 0.590 rs7582341 chr2:26416301 A/G cg25036284 chr2:26402008 FAM59B -0.6 -7.65 -0.39 2.29e-13 Gut microbiome composition (summer); CRC cis rs12291225 0.546 rs11023199 chr11:14394258 A/G cg05501817 chr11:14380813 RRAS2 -0.48 -6.61 -0.34 1.54e-10 Sense of smell; CRC cis rs9311474 0.508 rs11718420 chr3:52611413 T/C cg10802521 chr3:52805072 NEK4 -0.56 -8.89 -0.44 4e-17 Electroencephalogram traits; CRC cis rs9399135 0.967 rs9389254 chr6:135330709 C/T cg22676075 chr6:135203613 NA 0.41 6.35 0.33 7.03e-10 Red blood cell count; CRC cis rs896854 0.654 rs10104909 chr8:95977973 C/T cg13393036 chr8:95962371 TP53INP1 -0.52 -8.77 -0.44 9.72e-17 Type 2 diabetes; CRC cis rs9470366 0.883 rs9462207 chr6:36627599 T/C cg08179530 chr6:36648295 CDKN1A 0.53 6.32 0.33 8.65e-10 QRS duration; CRC cis rs10540 0.915 rs12419209 chr11:494510 T/C cg03576123 chr11:487126 PTDSS2 -1.04 -10.79 -0.51 1.91e-23 Body mass index; CRC cis rs4674676 1 rs4674676 chr2:223529112 A/G cg25565276 chr2:223520875 FARSB 1.11 13.68 0.6 4.92e-34 Chin dimples; CRC cis rs473651 0.904 rs508274 chr2:239337723 G/A cg08773314 chr2:239334832 ASB1 0.37 8.55 0.43 4.58e-16 Multiple system atrophy; CRC cis rs12580194 0.593 rs12579408 chr12:55764348 G/A cg19537932 chr12:55886519 OR6C68 -0.72 -9.12 -0.45 7.84e-18 Cancer; CRC cis rs10504229 0.683 rs11785258 chr8:58132893 A/G cg05313129 chr8:58192883 C8orf71 -0.43 -6.11 -0.32 2.74e-9 Developmental language disorder (linguistic errors); CRC cis rs1862618 0.641 rs170733 chr5:56249251 A/G cg18230493 chr5:56204884 C5orf35 0.6 8.99 0.44 1.95e-17 Initial pursuit acceleration; CRC trans rs208520 0.690 rs9345764 chr6:66820597 C/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.08 -15.19 -0.64 7.33e-40 Exhaled nitric oxide output; CRC cis rs6088580 0.609 rs6059844 chr20:33036482 A/G cg08999081 chr20:33150536 PIGU 0.58 11.04 0.52 2.47e-24 Glomerular filtration rate (creatinine); CRC cis rs4253772 0.637 rs41279831 chr22:46651623 T/C cg24881330 chr22:46731750 TRMU 0.57 5.7 0.3 2.61e-8 LDL cholesterol;Cholesterol, total; CRC cis rs9302635 0.513 rs12444701 chr16:72155240 C/T cg23815491 chr16:72088622 HP 0.57 7.32 0.37 1.9e-12 Blood protein levels; CRC cis rs9611565 0.608 rs2003816 chr22:42095140 T/G cg03806693 chr22:41940476 POLR3H 0.69 9.64 0.47 1.5700000000000001e-19 Vitiligo; CRC cis rs2204008 0.505 rs11182550 chr12:38570061 A/T cg26384229 chr12:38710491 ALG10B 0.45 6.44 0.33 4.32e-10 Bladder cancer; CRC trans rs2797369 0.713 rs4240592 chr6:101550593 G/A cg26346621 chr12:6873348 NA -0.4 -6.01 -0.31 4.93e-9 Renal function-related traits (eGRFcrea); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg21517261 chr7:38217791 STARD3NL 0.43 6.16 0.32 2.07e-9 Response to antipsychotic treatment; CRC trans rs7647973 0.626 rs2329021 chr3:49679072 G/A cg21665057 chr3:196295764 WDR53;FBXO45 -0.68 -7.46 -0.38 7.88e-13 Menarche (age at onset); CRC cis rs7584330 0.554 rs74003110 chr2:238448188 C/T cg14458575 chr2:238380390 NA 0.5 6.72 0.35 7.9e-11 Prostate cancer; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg09855692 chr3:15643242 HACL1;BTD 0.45 6.28 0.33 1.04e-9 Response to antipsychotic treatment; CRC cis rs7264396 0.563 rs6058312 chr20:34324484 A/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.49 -6.55 -0.34 2.15e-10 Total cholesterol levels; CRC trans rs3942852 0.806 rs11039515 chr11:48119474 A/G cg15704280 chr7:45808275 SEPT13 0.62 8.06 0.41 1.4e-14 Acute lymphoblastic leukemia (childhood); CRC cis rs875971 0.964 rs697969 chr7:65558478 C/A cg18876405 chr7:65276391 NA -0.53 -9.14 -0.45 6.65e-18 Aortic root size; CRC cis rs1448094 0.511 rs11117023 chr12:86145329 G/A cg00310523 chr12:86230176 RASSF9 -0.36 -5.92 -0.31 8.25e-9 Major depressive disorder; CRC cis rs1577917 0.771 rs2842602 chr6:86331887 C/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.69 -9.28 -0.46 2.39e-18 Response to antipsychotic treatment; CRC cis rs7811142 0.943 rs10241492 chr7:99994813 A/G cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.17 16.78 0.68 4.24e-46 Platelet count; CRC cis rs6502050 0.842 rs7211808 chr17:80071244 T/C cg25804541 chr17:80189381 SLC16A3 0.32 6.03 0.32 4.47e-9 Life satisfaction; CRC cis rs2346160 0.836 rs206991 chr6:167699378 A/G cg04673565 chr6:167680447 NA -0.4 -6.73 -0.35 7.34e-11 Parental extreme longevity (95 years and older); CRC cis rs4713118 0.955 rs9368529 chr6:27684631 G/A cg06470822 chr6:28175283 NA 0.67 9.0 0.44 1.8e-17 Parkinson's disease; CRC cis rs66573146 1.000 rs6838042 chr4:6973049 G/T cg00086871 chr4:6988644 TBC1D14 0.92 6.5 0.34 2.99e-10 Granulocyte percentage of myeloid white cells; CRC cis rs2617583 0.599 rs2975226 chr5:1445616 A/T cg07151155 chr5:1473589 LPCAT1 -0.38 -5.83 -0.31 1.36e-8 Breast cancer; CRC cis rs7680126 0.596 rs4698009 chr4:10284993 A/G cg11266682 chr4:10021025 SLC2A9 -0.38 -6.01 -0.31 4.9e-9 Urate levels in lean individuals;Urate levels in overweight individuals;Urate levels in obese individuals; CRC trans rs7726839 0.540 rs3749618 chr5:602650 A/G cg11887960 chr12:57824829 NA 0.59 6.56 0.34 2.12e-10 Obesity-related traits; CRC cis rs11098499 0.821 rs3775852 chr4:120454556 A/G cg09307838 chr4:120376055 NA 0.69 10.34 0.5 6.68e-22 Corneal astigmatism; CRC trans rs2303319 0.504 rs56009150 chr2:162598582 T/C cg21546874 chr1:9294571 H6PD -0.7 -6.03 -0.32 4.44e-9 Cognitive function; CRC cis rs8177253 1.000 rs8177271 chr3:133482230 G/A cg16262614 chr3:133464971 TF 0.35 6.18 0.32 1.88e-9 Iron status biomarkers; CRC cis rs12681288 0.676 rs2701914 chr8:999935 C/T cg15309053 chr8:964076 NA 0.44 7.44 0.38 8.61e-13 Schizophrenia; CRC cis rs4654899 0.833 rs10916919 chr1:21317524 A/G cg02927042 chr1:21476669 EIF4G3 0.52 8.5 0.42 6.66e-16 Superior frontal gyrus grey matter volume; CRC trans rs9747201 1.000 rs62078307 chr17:80090053 G/T cg07393940 chr7:158741817 NA -0.52 -7.45 -0.38 8.41e-13 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs1153858 1.000 rs12594857 chr15:45667178 A/G cg21132104 chr15:45694354 SPATA5L1 0.59 8.51 0.42 6.4e-16 Homoarginine levels; CRC cis rs501916 0.605 rs11632156 chr15:48082099 A/G cg16110827 chr15:48056943 SEMA6D -0.48 -7.28 -0.37 2.53e-12 Inflammatory bowel disease;Ulcerative colitis; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg03249710 chr13:48611439 NUDT15 0.45 5.99 0.31 5.47e-9 Thyroid stimulating hormone; CRC cis rs7927592 0.763 rs7129248 chr11:68263276 A/T cg01657329 chr11:68192670 LRP5 -0.55 -9.01 -0.44 1.71e-17 Total body bone mineral density; CRC cis rs11077815 0.733 rs7219524 chr17:74442440 C/G cg06840243 chr17:74442338 UBE2O -0.42 -6.69 -0.35 9.54e-11 Lymphocyte counts; CRC cis rs11098499 0.754 rs28652763 chr4:120242312 C/T cg09307838 chr4:120376055 NA 0.62 9.71 0.47 9.4e-20 Corneal astigmatism; CRC cis rs1799949 1.000 rs2271574 chr17:41327648 T/C cg05368731 chr17:41323189 NBR1 0.69 10.45 0.5 2.95e-22 Menopause (age at onset); CRC cis rs10504229 0.639 rs35527749 chr8:58128077 G/T cg02290350 chr8:58132656 NA -0.61 -7.12 -0.37 6.7e-12 Developmental language disorder (linguistic errors); CRC trans rs6601327 0.641 rs12155819 chr8:9572679 A/G cg06636001 chr8:8085503 FLJ10661 -0.51 -7.42 -0.38 1.03e-12 Multiple myeloma (hyperdiploidy); CRC cis rs61160187 0.582 rs12652878 chr5:60164776 C/T cg16298547 chr5:60138761 ELOVL7 -0.29 -6.02 -0.32 4.6e-9 Educational attainment (years of education);Educational attainment (college completion); CRC cis rs853679 0.607 rs34950484 chr6:28278688 G/A cg12185399 chr6:27640341 NA 0.83 6.03 0.32 4.38e-9 Depression; CRC cis rs1403694 0.655 rs3806688 chr3:186434819 T/C cg04611788 chr3:186434169 KNG1 -0.61 -9.13 -0.45 7.33e-18 Blood protein levels; CRC cis rs2933343 0.859 rs789245 chr3:128583580 C/A cg11901034 chr3:128598214 ACAD9 -0.52 -6.2 -0.32 1.65e-9 IgG glycosylation; CRC cis rs6951245 0.872 rs77569514 chr7:1085508 G/A cg18402987 chr7:1209562 NA 0.65 6.84 0.35 3.98e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs12540874 0.542 rs3807562 chr7:50566671 G/A cg18232548 chr7:50535776 DDC -0.49 -7.44 -0.38 9.05e-13 Systemic sclerosis; CRC cis rs4862750 0.832 rs6836426 chr4:187897837 T/G cg27532560 chr4:187881888 NA -0.56 -10.38 -0.5 5e-22 Lobe attachment (rater-scored or self-reported); CRC cis rs9715521 0.868 rs6856620 chr4:59820960 A/G cg11281224 chr4:60001000 NA -0.39 -5.78 -0.3 1.69e-8 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs55665837 1.000 rs10832275 chr11:14478224 A/C cg19336497 chr11:14380999 RRAS2 -0.4 -6.75 -0.35 6.85e-11 Vitamin D levels; CRC cis rs7727544 0.901 rs55633655 chr5:131598756 T/G cg14196790 chr5:131705035 SLC22A5 0.32 5.72 0.3 2.37e-8 Blood metabolite levels; CRC cis rs7945705 0.905 rs2568054 chr11:8876029 A/G cg12365402 chr11:9010492 NRIP3 -0.48 -8.11 -0.41 9.99e-15 Hemoglobin concentration; CRC cis rs873946 0.517 rs7071784 chr10:134559980 T/C cg18305652 chr10:134549665 INPP5A 0.51 7.52 0.38 5.12e-13 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CRC cis rs9611565 0.512 rs4820446 chr22:42215684 C/T cg17554472 chr22:41940697 POLR3H -0.6 -6.0 -0.31 5.13e-9 Vitiligo; CRC cis rs10256972 0.681 rs6979076 chr7:1116247 C/T cg23978390 chr7:1156363 C7orf50 -0.47 -6.49 -0.34 3.24e-10 Longevity;Endometriosis; CRC trans rs7011507 1.000 rs74451002 chr8:49191234 C/A cg04544946 chr8:978226 NA 0.43 6.18 0.32 1.92e-9 Inflammatory bowel disease;Ulcerative colitis; CRC cis rs6952808 0.529 rs73038442 chr7:2139457 C/T cg21782813 chr7:2030301 MAD1L1 0.54 9.45 0.46 6.57e-19 Bipolar disorder and schizophrenia; CRC cis rs2281845 0.965 rs3738262 chr1:201083343 A/G cg01987224 chr1:201084466 NA 0.53 9.84 0.48 3.42e-20 Permanent tooth development; CRC cis rs4481887 1.000 rs4579792 chr1:248463742 C/T cg00666640 chr1:248458726 OR2T12 -0.53 -9.39 -0.46 1.07e-18 Common traits (Other); CRC cis rs2516839 0.605 rs12749496 chr1:161021893 G/C cg11578532 chr1:161008127 TSTD1 0.28 5.83 0.31 1.33e-8 Granulocyte percentage of myeloid white cells; CRC trans rs11148252 0.712 rs61957257 chr13:52769702 G/A cg18335740 chr13:41363409 SLC25A15 0.56 8.91 0.44 3.59e-17 Lewy body disease; CRC cis rs2075371 0.965 rs2544216 chr7:133987902 G/A cg02659138 chr7:134003124 SLC35B4 0.37 6.4 0.33 5.45e-10 Mean platelet volume; CRC trans rs208520 0.690 rs1233103 chr6:66855943 T/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.05 -14.78 -0.63 3.02e-38 Exhaled nitric oxide output; CRC cis rs4819052 0.851 rs12626188 chr21:46669258 A/G cg02159808 chr21:46707872 POFUT2;LOC642852 0.47 6.04 0.32 4.19e-9 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs7589728 1.000 rs2363731 chr2:88521793 C/T cg07952391 chr2:88470173 THNSL2 0.66 6.74 0.35 6.94e-11 Plasma clusterin levels; CRC cis rs9393692 0.905 rs9393693 chr6:26277408 C/A cg13736514 chr6:26305472 NA -0.61 -11.46 -0.53 8.56e-26 Educational attainment; CRC cis rs8177179 0.967 rs4994581 chr3:133437563 T/C cg24879335 chr3:133465180 TF 0.44 8.62 0.43 2.9e-16 Iron status biomarkers (transferrin levels); CRC cis rs4474465 0.850 rs11237546 chr11:78266924 T/C cg27205649 chr11:78285834 NARS2 0.5 6.52 0.34 2.67e-10 Alzheimer's disease (survival time); CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg12896751 chr2:97536137 SEMA4C 0.45 6.09 0.32 3.23e-9 Thyroid stimulating hormone; CRC cis rs9894429 0.634 rs11655346 chr17:79572399 A/G cg09655341 chr17:79618100 PDE6G 0.36 6.22 0.32 1.5e-9 Eye color traits; CRC cis rs780096 0.565 rs813592 chr2:27721971 T/C cg12648201 chr2:27665141 KRTCAP3 -0.28 -5.73 -0.3 2.27e-8 Total body bone mineral density; CRC cis rs185694 1.000 rs846495 chr13:30894250 T/C cg04551440 chr13:30881194 KATNAL1 -0.63 -6.5 -0.34 2.97e-10 Antineutrophil cytoplasmic antibody-associated vasculitis; CRC cis rs9311474 0.508 rs4687629 chr3:52615227 G/C cg11645453 chr3:52864694 ITIH4 0.35 6.3 0.33 9.46e-10 Electroencephalogram traits; CRC cis rs514406 0.825 rs7523761 chr1:53250915 T/C cg24675658 chr1:53192096 ZYG11B 0.6 9.48 0.46 5.21e-19 Monocyte count; CRC cis rs12745968 0.589 rs7513775 chr1:93004497 T/C cg17283838 chr1:93427260 FAM69A -0.45 -6.21 -0.32 1.59e-9 Bipolar disorder and schizophrenia; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg07921184 chr16:71880281 ATXN1L 0.48 6.42 0.33 4.68e-10 Anxiety disorder; CRC cis rs2153535 0.580 rs6597337 chr6:8531652 C/T cg21535247 chr6:8435926 SLC35B3 0.49 7.51 0.38 5.8e-13 Motion sickness; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg14221825 chr19:46271408 SIX5 0.48 6.33 0.33 8.13e-10 Anxiety disorder; CRC cis rs7493 0.901 rs2237586 chr7:95051052 G/T cg17330251 chr7:94953956 PON1 -0.6 -7.49 -0.38 6.26e-13 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs13118159 0.714 rs6843025 chr4:1334418 C/G cg15763984 chr4:1342303 KIAA1530 0.48 8.41 0.42 1.3e-15 Longevity; CRC cis rs798554 0.836 rs2260230 chr7:2822986 T/A cg19346786 chr7:2764209 NA -0.44 -7.76 -0.39 1.07e-13 Height; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg11653107 chr12:6832969 COPS7A 0.5 7.1 0.36 7.98e-12 Response to antipsychotic treatment; CRC cis rs2832191 1.000 rs8131214 chr21:30483386 T/G cg08807101 chr21:30365312 RNF160 -0.62 -9.96 -0.48 1.3e-20 Dental caries; CRC cis rs4499344 0.633 rs259239 chr19:33141090 C/T cg08127369 chr19:33164662 ANKRD27 0.39 6.06 0.32 3.8e-9 Mean platelet volume; CRC cis rs6502050 0.835 rs8067138 chr17:80111026 T/C cg13198984 chr17:80129470 CCDC57 0.46 8.16 0.41 6.94e-15 Life satisfaction; CRC cis rs2180341 1.000 rs7453272 chr6:127633959 C/T cg27446573 chr6:127587934 RNF146 -0.94 -12.36 -0.56 4.37e-29 Breast cancer; CRC trans rs6956675 1.000 rs1609527 chr7:62599257 C/T cg01314568 chr7:57830625 NA -0.68 -9.27 -0.46 2.56e-18 Obesity-related traits; CRC cis rs2976388 0.647 rs2244163 chr8:143784500 T/G cg15511327 chr8:143859410 LYNX1 0.4 7.16 0.37 5.19e-12 Urinary tract infection frequency; CRC cis rs28386778 0.829 rs1877317 chr17:61776479 T/C cg00280220 chr17:61926910 NA 0.35 5.72 0.3 2.4e-8 Prudent dietary pattern; CRC cis rs3956705 0.798 rs35443929 chr7:32935434 C/A cg05721444 chr7:32995514 FKBP9 -0.44 -6.39 -0.33 5.58e-10 Red cell distribution width; CRC cis rs67311347 0.955 rs6764102 chr3:40378153 C/G cg09455208 chr3:40491958 NA 0.44 8.84 0.44 5.82e-17 Renal cell carcinoma; CRC cis rs7772486 0.790 rs6924159 chr6:146267873 A/G cg23711669 chr6:146136114 FBXO30 -0.72 -12.62 -0.57 4.76e-30 Lobe attachment (rater-scored or self-reported); CRC cis rs12586317 1.000 rs12586317 chr14:35682172 T/C cg16230307 chr14:35515116 FAM177A1 0.6 6.92 0.36 2.34e-11 Psoriasis; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg03273382 chr1:205782342 SLC41A1 0.47 6.64 0.34 1.3e-10 Response to antipsychotic treatment; CRC trans rs891992 1.000 rs4705045 chr5:147220041 T/G cg19319393 chr1:6321737 GPR153 0.47 5.96 0.31 6.46e-9 Obesity-related traits; CRC cis rs7829975 0.684 rs488904 chr8:8587571 T/G cg06636001 chr8:8085503 FLJ10661 -0.52 -8.13 -0.41 8.87e-15 Mood instability; CRC cis rs28374715 0.532 rs28703570 chr15:41679492 G/A cg18705301 chr15:41695430 NDUFAF1 -1.12 -20.07 -0.74 4.73e-59 Ulcerative colitis; CRC cis rs148734725 1 rs148734725 chr3:49406708 G/A cg03060546 chr3:49711283 APEH -0.48 -6.85 -0.35 3.71e-11 Educational attainment (college completion); CRC cis rs7584330 0.518 rs79618460 chr2:238419959 T/C cg14458575 chr2:238380390 NA 0.86 10.4 0.5 4.31e-22 Prostate cancer; CRC trans rs853679 1.000 rs1778511 chr6:28229411 G/A cg06606381 chr12:133084897 FBRSL1 0.59 5.99 0.31 5.48e-9 Depression; CRC cis rs1552244 0.554 rs34883592 chr3:10046165 C/T cg00166722 chr3:10149974 C3orf24 0.43 6.37 0.33 6.32e-10 Alzheimer's disease; CRC cis rs4141404 0.781 rs4820945 chr22:31549155 T/C cg22777020 chr22:31556080 RNF185 -0.47 -5.65 -0.3 3.54e-8 Paclitaxel-induced neuropathy; CRC cis rs10504229 0.683 rs72649192 chr8:58110490 T/C cg21724239 chr8:58056113 NA 0.73 9.31 0.46 1.83e-18 Developmental language disorder (linguistic errors); CRC cis rs908922 0.676 rs12116609 chr1:152497685 C/T cg09873164 chr1:152488093 CRCT1 0.37 6.13 0.32 2.45e-9 Hair morphology; CRC cis rs611744 0.647 rs2859813 chr8:109263497 G/A cg21045802 chr8:109455806 TTC35 0.42 6.61 0.34 1.51e-10 Dupuytren's disease; CRC trans rs7944735 0.545 rs4752805 chr11:48018355 A/G cg03929089 chr4:120376271 NA 0.51 6.71 0.35 8.42e-11 Intraocular pressure; CRC cis rs9814567 1.000 rs7428326 chr3:134251184 A/G cg06541857 chr3:134203789 ANAPC13;CEP63 -0.4 -6.12 -0.32 2.65e-9 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs2976388 1.000 rs2294010 chr8:143762430 A/G cg04969067 chr8:143858791 LYNX1 -0.35 -5.98 -0.31 5.67e-9 Urinary tract infection frequency; CRC cis rs9311474 0.597 rs13303 chr3:52558008 T/C cg13284614 chr3:52569169 NT5DC2;LOC440957 0.37 6.02 0.31 4.69e-9 Electroencephalogram traits; CRC cis rs910316 1.000 rs10142865 chr14:75555624 G/A cg11812906 chr14:75593930 NEK9 0.64 10.38 0.5 5.13e-22 Height; CRC cis rs2243480 0.803 rs55700941 chr7:65389800 T/A cg12463550 chr7:65579703 CRCP 0.66 6.23 0.32 1.44e-9 Diabetic kidney disease; CRC cis rs4824093 0.535 rs73443931 chr22:50291603 G/A cg22709217 chr22:50311962 ALG12;CRELD2 -0.97 -8.49 -0.42 7.01e-16 Amyotrophic lateral sclerosis (sporadic); CRC cis rs3806843 0.735 rs809635 chr5:140081791 A/G cg19875535 chr5:140030758 IK -0.63 -10.51 -0.5 1.78e-22 Depressive symptoms (multi-trait analysis); CRC cis rs116095464 0.558 rs62347678 chr5:227496 A/G cg22496380 chr5:211416 CCDC127 -0.81 -9.73 -0.47 7.64e-20 Breast cancer; CRC cis rs2153535 0.580 rs7341201 chr6:8470270 T/C cg07606381 chr6:8435919 SLC35B3 0.68 10.9 0.51 8.26e-24 Motion sickness; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg12624087 chr22:32341561 C22orf24;YWHAH 0.52 6.74 0.35 6.92e-11 Thyroid stimulating hormone; CRC cis rs950027 0.620 rs35861938 chr15:45637343 T/C cg21132104 chr15:45694354 SPATA5L1 0.42 6.15 0.32 2.29e-9 Response to fenofibrate (adiponectin levels); CRC cis rs9787249 0.874 rs12094291 chr1:40226046 G/A cg01941586 chr1:40203715 PPIE -0.42 -5.76 -0.3 1.97e-8 Blood protein levels; CRC cis rs6662572 0.737 rs11211211 chr1:46340554 G/T cg03123370 chr1:45965343 CCDC163P;MMACHC -0.46 -5.9 -0.31 8.93e-9 Blood protein levels; CRC cis rs1976403 0.659 rs10799699 chr1:21820961 C/T cg20417195 chr1:21767127 NBPF3 0.44 6.61 0.34 1.56e-10 Liver enzyme levels (alkaline phosphatase); CRC trans rs7395662 0.517 rs10838960 chr11:48584741 A/G cg00717180 chr2:96193071 NA -0.37 -5.99 -0.31 5.48e-9 HDL cholesterol; CRC cis rs17270561 0.583 rs6908713 chr6:25703611 G/A cg16482183 chr6:26056742 HIST1H1C -0.72 -9.17 -0.45 5.43e-18 Iron status biomarkers; CRC cis rs11758351 0.660 rs11753655 chr6:26220109 C/T cg10723962 chr6:26240782 HIST1H4F -0.38 -6.22 -0.32 1.54e-9 Gout;Renal underexcretion gout; CRC cis rs3892630 0.878 rs11878394 chr19:33205844 G/C cg22980127 chr19:33182716 NUDT19 0.9 11.11 0.52 1.48e-24 Red blood cell traits; CRC cis rs7786808 0.707 rs10247026 chr7:158230595 C/T cg09998033 chr7:158218633 PTPRN2 -0.64 -9.03 -0.45 1.47e-17 Obesity-related traits; CRC cis rs7589728 0.563 rs78168096 chr2:88473575 G/A cg14558114 chr2:88469736 THNSL2 0.57 5.67 0.3 3.21e-8 Plasma clusterin levels; CRC cis rs9660992 0.710 rs1172136 chr1:205247097 T/G cg21643547 chr1:205240462 TMCC2 -0.45 -7.25 -0.37 2.98e-12 Mean corpuscular volume;Mean platelet volume; CRC cis rs2576037 0.583 rs9954336 chr18:44465945 A/G cg19077165 chr18:44547161 KATNAL2 -0.66 -11.39 -0.53 1.42e-25 Personality dimensions; CRC cis rs2836974 0.932 rs8129416 chr21:40617145 C/T cg11890956 chr21:40555474 PSMG1 1.09 18.8 0.72 4.57e-54 Cognitive function; CRC cis rs887829 0.641 rs10197460 chr2:234589190 G/T cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.41 -6.21 -0.32 1.62e-9 Metabolic traits;Bilirubin levels;Cholelithiasis-related traits in sickle cell anemia;Metabolite levels;Total bilirubin levels in HIV-1 infection;Serum metabolite levels;Blood metabolite levels; CRC cis rs2404602 0.692 rs7350777 chr15:76985441 G/A cg22467129 chr15:76604101 ETFA -0.41 -6.78 -0.35 5.59e-11 Blood metabolite levels; CRC cis rs4919694 0.808 rs4918001 chr10:105013147 G/T cg04362960 chr10:104952993 NT5C2 -1.03 -9.0 -0.44 1.84e-17 Arsenic metabolism; CRC cis rs28386778 0.897 rs2854214 chr17:61945449 C/G cg06601766 chr17:61851465 DDX42;CCDC47 -0.44 -5.96 -0.31 6.43e-9 Prudent dietary pattern; CRC cis rs1707322 0.717 rs2991988 chr1:46082431 C/A cg06784218 chr1:46089804 CCDC17 -0.66 -12.05 -0.55 5.86e-28 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs644799 0.965 rs499076 chr11:95546341 A/G cg25478527 chr11:95522999 CEP57;FAM76B 0.51 7.69 0.39 1.68e-13 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs9807989 0.811 rs11689730 chr2:102969984 C/A cg03938978 chr2:103052716 IL18RAP 0.37 5.97 0.31 6.2e-9 Asthma; CRC cis rs9916302 0.706 rs12947506 chr17:37707592 A/G cg15445000 chr17:37608096 MED1 0.32 5.7 0.3 2.69e-8 Glomerular filtration rate (creatinine); CRC cis rs7647973 0.580 rs11716334 chr3:49230096 G/A cg20833759 chr3:49053208 WDR6;DALRD3 0.39 6.54 0.34 2.29e-10 Menarche (age at onset); CRC cis rs6840360 0.615 rs12641441 chr4:152607623 A/G cg09659197 chr4:152720779 NA 0.4 7.89 0.4 4.59e-14 Intelligence (multi-trait analysis); CRC cis rs6563842 0.563 rs4575411 chr13:41277794 C/G cg21288729 chr13:41239152 FOXO1 0.43 6.76 0.35 6.47e-11 Eosinophil percentage of granulocytes;Sum eosinophil basophil counts;Eosinophil percentage of white cells; CRC cis rs8077889 0.645 rs1230396 chr17:41843029 A/C cg16892393 chr17:41919603 NA -0.37 -5.88 -0.31 9.96e-9 Triglycerides; CRC cis rs1862618 0.853 rs832582 chr5:56177743 G/A cg24531977 chr5:56204891 C5orf35 -0.84 -10.92 -0.52 6.54e-24 Initial pursuit acceleration; CRC cis rs4665809 0.567 rs6546848 chr2:26444414 G/C cg08067268 chr2:26466485 HADHB;HADHA -0.64 -8.33 -0.42 2.17e-15 Gut microbiome composition (summer); CRC cis rs6840360 0.681 rs9968292 chr4:152297368 T/C cg09659197 chr4:152720779 NA 0.32 6.2 0.32 1.71e-9 Intelligence (multi-trait analysis); CRC cis rs7208859 0.673 rs11657270 chr17:29214387 A/G cg13385521 chr17:29058706 SUZ12P 0.61 6.99 0.36 1.52e-11 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC trans rs61931739 0.534 rs11052983 chr12:34045787 C/A cg26384229 chr12:38710491 ALG10B 0.51 6.96 0.36 1.82e-11 Morning vs. evening chronotype; CRC cis rs8077889 0.703 rs231531 chr17:41946180 A/C cg16892393 chr17:41919603 NA 0.46 6.44 0.33 4.15e-10 Triglycerides; CRC cis rs9914988 0.943 rs9890155 chr17:27125467 A/G cg07195577 chr17:27052828 TLCD1 0.42 6.02 0.32 4.64e-9 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs7954584 0.545 rs12824593 chr12:122374108 G/A cg22618164 chr12:122356400 WDR66 0.37 5.61 0.3 4.23e-8 Mean corpuscular volume; CRC cis rs6831352 0.918 rs28987088 chr4:100059139 T/C cg12011299 chr4:100065546 ADH4 -0.49 -9.27 -0.45 2.61e-18 Alcohol dependence; CRC cis rs9942416 0.660 rs66493518 chr5:74990125 G/C cg19683494 chr5:74908142 NA 0.51 6.36 0.33 6.81e-10 Age-related disease endophenotypes; CRC cis rs6860806 0.507 rs274570 chr5:131713226 C/T cg02033258 chr5:131593261 PDLIM4 -0.37 -6.13 -0.32 2.5e-9 Breast cancer; CRC cis rs7618915 0.571 rs33964154 chr3:52596914 A/G cg08222913 chr3:52553049 STAB1 -0.34 -6.3 -0.33 9.34e-10 Bipolar disorder; CRC cis rs2688482 0.557 rs2550236 chr3:195522321 A/G cg13752114 chr3:195489708 MUC4 0.76 8.73 0.43 1.29e-16 Lung disease severity in cystic fibrosis; CRC cis rs6724607 0.905 rs7603849 chr2:191438741 A/C cg21644426 chr2:191273491 MFSD6 0.48 6.53 0.34 2.46e-10 Pulse pressure; CRC cis rs2836950 0.545 rs4818001 chr21:40575088 T/C cg11644478 chr21:40555479 PSMG1 -0.5 -7.36 -0.38 1.44e-12 Menarche (age at onset); CRC cis rs10256972 0.577 rs6962809 chr7:1208889 A/G cg04025307 chr7:1156635 C7orf50 0.64 10.08 0.49 5.24e-21 Longevity;Endometriosis; CRC cis rs7772486 0.654 rs9376958 chr6:146023040 C/T cg13319975 chr6:146136371 FBXO30 0.42 6.22 0.32 1.48e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs9309711 0.666 rs11127429 chr2:3485224 T/G cg10845886 chr2:3471009 TTC15 -0.4 -6.29 -0.33 1.01e-9 Neurofibrillary tangles; CRC cis rs6563739 0.655 rs9594359 chr13:40223878 C/T cg00026919 chr13:40226031 NA 0.5 6.41 0.33 5.18e-10 Menarche (age at onset); CRC cis rs4862750 0.837 rs1863404 chr4:187874654 T/C cg03647317 chr4:187891568 NA -0.54 -10.13 -0.49 3.48e-21 Lobe attachment (rater-scored or self-reported); CRC trans rs4824093 0.535 rs73443931 chr22:50291603 G/A cg09872104 chr7:134855509 C7orf49 -0.82 -7.2 -0.37 4e-12 Amyotrophic lateral sclerosis (sporadic); CRC trans rs1656966 1.000 rs1656966 chr3:186466252 C/T cg02548780 chr16:22020026 C16orf52 0.42 6.52 0.34 2.65e-10 Myopia (pathological); CRC trans rs12599106 0.770 rs12445057 chr16:34970274 C/G cg15383120 chr6:291909 DUSP22 -0.58 -8.21 -0.41 5.25e-15 Menopause (age at onset); CRC cis rs4713118 0.866 rs2179094 chr6:27741825 T/C cg26587870 chr6:27730563 NA -0.45 -6.68 -0.35 1e-10 Parkinson's disease; CRC cis rs1129187 0.755 rs7760250 chr6:42929839 G/A cg09436375 chr6:42928200 GNMT -0.34 -6.38 -0.33 6e-10 Alzheimer's disease in APOE e4+ carriers; CRC cis rs7044106 0.734 rs10491784 chr9:123432289 A/C cg14255062 chr9:123606675 PSMD5;LOC253039 0.44 6.66 0.34 1.16e-10 Hip circumference adjusted for BMI; CRC cis rs13118159 0.714 rs6843025 chr4:1334418 C/G cg16405210 chr4:1374714 KIAA1530 -0.44 -6.2 -0.32 1.71e-9 Longevity; CRC cis rs9287719 0.904 rs55738250 chr2:10757132 G/A cg00105475 chr2:10696890 NA 0.44 7.14 0.37 6.13e-12 Prostate cancer; CRC cis rs6912958 0.754 rs7762864 chr6:88236213 A/G cg08069147 chr6:88032118 GJB7;C6orf162 -0.57 -8.46 -0.42 9e-16 Monocyte percentage of white cells; CRC cis rs4253772 0.591 rs7286155 chr22:46714735 A/G cg09491104 chr22:46646882 C22orf40 -0.43 -5.84 -0.31 1.28e-8 LDL cholesterol;Cholesterol, total; CRC cis rs12048904 0.619 rs12239082 chr1:101330077 G/T cg00063077 chr1:101360652 SLC30A7;EXTL2 -0.79 -12.08 -0.55 4.76e-28 Multiple sclerosis; CRC cis rs9811920 0.529 rs793442 chr3:99581062 A/T cg07805332 chr3:99536008 MIR548G;C3orf26 0.54 8.22 0.41 4.59e-15 Axial length; CRC cis rs4481887 1.000 rs4244179 chr1:248470984 T/A cg13385794 chr1:248469461 NA 0.37 6.44 0.33 4.21e-10 Common traits (Other); CRC cis rs4727027 0.901 rs11760293 chr7:148811725 A/G cg23583168 chr7:148888333 NA -0.93 -16.04 -0.66 3.49e-43 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC cis rs34172651 0.876 rs7186893 chr16:24806420 G/T cg00339695 chr16:24857497 SLC5A11 0.29 6.54 0.34 2.41e-10 Intelligence (multi-trait analysis); CRC cis rs1223397 0.589 rs364493 chr6:13297020 C/T cg00460589 chr6:13274354 PHACTR1 -0.41 -6.07 -0.32 3.54e-9 Blood pressure; CRC cis rs2836950 0.565 rs2836945 chr21:40596757 C/T cg11890956 chr21:40555474 PSMG1 -0.67 -10.04 -0.48 7.14e-21 Menarche (age at onset); CRC cis rs1506636 1.000 rs676755 chr7:123439082 A/G cg03229431 chr7:123269106 ASB15 -0.69 -10.86 -0.51 1.14e-23 Plateletcrit;Platelet count; CRC cis rs7312933 0.558 rs1669886 chr12:42838240 A/G cg11827402 chr12:42719852 PPHLN1;ZCRB1 -0.66 -9.75 -0.47 6.77e-20 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CRC cis rs7937682 0.889 rs564086 chr11:111501079 C/G cg19812747 chr11:111475976 SIK2 -0.59 -10.07 -0.49 5.83e-21 Primary sclerosing cholangitis; CRC trans rs1945213 0.625 rs7128190 chr11:55858550 A/T cg03929089 chr4:120376271 NA 0.59 6.66 0.34 1.17e-10 Acute lymphoblastic leukemia (childhood); CRC trans rs10028773 0.568 rs6838457 chr4:120267367 A/G cg25214090 chr10:38739885 LOC399744 0.53 8.51 0.42 6.36e-16 Educational attainment; CRC cis rs7917772 0.636 rs2249850 chr10:104512006 A/G cg04362960 chr10:104952993 NT5C2 -0.48 -5.95 -0.31 6.91e-9 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC cis rs13108904 0.905 rs1680074 chr4:1279621 G/A cg19318889 chr4:1322082 MAEA -0.42 -6.47 -0.34 3.53e-10 Obesity-related traits; CRC trans rs4386084 1.000 rs7175764 chr15:50220398 C/T cg02453146 chr1:53068587 GPX7 0.34 6.11 0.32 2.75e-9 Basophil percentage of white cells;Basophil percentage of granulocytes; CRC cis rs2180341 0.920 rs6916990 chr6:127698759 G/A cg24812749 chr6:127587940 RNF146 0.97 13.58 0.6 1.17e-33 Breast cancer; CRC cis rs6088580 0.609 rs945674 chr20:32964247 G/C cg08999081 chr20:33150536 PIGU -0.61 -11.54 -0.54 4.11e-26 Glomerular filtration rate (creatinine); CRC cis rs4900538 0.855 rs72698597 chr14:102868633 C/T cg18135206 chr14:102964638 TECPR2 -0.97 -17.52 -0.69 5.33e-49 Mean corpuscular volume;Mean corpuscular hemoglobin; CRC cis rs7586879 0.687 rs11892869 chr2:25096692 A/T cg22495460 chr2:25135724 ADCY3 -0.85 -16.31 -0.67 3.12e-44 Body mass index; CRC cis rs1552244 0.572 rs113406084 chr3:10170190 T/C cg13047869 chr3:10149882 C3orf24 0.53 6.49 0.34 3.25e-10 Alzheimer's disease; CRC cis rs4253772 0.591 rs9627324 chr22:46656511 A/G cg03482458 chr22:46692211 CN5H6.4;GTSE1 0.52 6.9 0.36 2.65e-11 LDL cholesterol;Cholesterol, total; CRC cis rs1448094 0.512 rs6539924 chr12:86236935 T/C cg19622623 chr12:86230825 RASSF9 -0.42 -6.76 -0.35 6.21e-11 Major depressive disorder; CRC cis rs7493 1.000 rs2299264 chr7:95046708 C/T cg17330251 chr7:94953956 PON1 -0.57 -7.54 -0.38 4.65e-13 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs4604732 0.536 rs12049066 chr1:247642655 C/T cg12758973 chr1:247694275 LOC148824;OR2C3 0.43 6.51 0.34 2.88e-10 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CRC cis rs12497850 0.797 rs61583136 chr3:49189195 C/T cg20833759 chr3:49053208 WDR6;DALRD3 0.45 7.23 0.37 3.48e-12 Parkinson's disease; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg16925090 chr11:101785516 KIAA1377;ANGPTL5 0.47 6.3 0.33 9.66e-10 Thyroid stimulating hormone; CRC cis rs875971 0.798 rs6460304 chr7:65964728 G/A cg18252515 chr7:66147081 NA -0.42 -6.14 -0.32 2.37e-9 Aortic root size; CRC cis rs2062225 1.000 rs6733493 chr2:111773473 C/T cg11729679 chr2:111877065 BCL2L11 0.57 5.67 0.3 3.06e-8 Monocyte count; CRC cis rs7089973 0.584 rs6585300 chr10:116639889 A/C cg23260525 chr10:116636907 FAM160B1 0.39 9.15 0.45 6.36e-18 Bipolar disorder or attention deficit hyperactivity disorder; CRC cis rs2239547 0.522 rs6768844 chr3:53004620 A/G cg10802521 chr3:52805072 NEK4 0.43 5.97 0.31 6.3e-9 Schizophrenia; CRC cis rs780096 0.526 rs704795 chr2:27716494 G/A cg27432699 chr2:27873401 GPN1 -0.52 -7.93 -0.4 3.34e-14 Total body bone mineral density; CRC cis rs9291683 0.595 rs3733585 chr4:10036339 A/G cg00071950 chr4:10020882 SLC2A9 0.67 12.67 0.57 3.24e-30 Bone mineral density; CRC cis rs2075371 0.966 rs1646676 chr7:133999267 G/A cg02659138 chr7:134003124 SLC35B4 0.4 6.94 0.36 2.09e-11 Mean platelet volume; CRC cis rs2310173 0.575 rs4850993 chr2:102622466 G/C cg20856504 chr2:102616538 IL1R2 0.37 5.94 0.31 7.4e-9 Ankylosing spondylitis;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined);Ulcerative colitis; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg19281693 chr22:42666674 NA 0.48 6.86 0.35 3.44e-11 Response to antipsychotic treatment; CRC cis rs2652834 0.808 rs28583444 chr15:63357852 T/G cg05507819 chr15:63340323 TPM1 0.45 5.85 0.31 1.19e-8 HDL cholesterol; CRC cis rs9611565 0.694 rs7285041 chr22:41829149 G/T cg03806693 chr22:41940476 POLR3H 1.12 13.67 0.6 5.31e-34 Vitiligo; CRC cis rs2976388 0.556 rs4736321 chr8:143822194 C/T cg20041105 chr8:143859282 LYNX1 -0.41 -6.48 -0.34 3.38e-10 Urinary tract infection frequency; CRC cis rs9902453 1.000 rs7221743 chr17:28407876 T/G cg26525008 chr17:28256777 EFCAB5;SSH2 -0.59 -8.9 -0.44 3.84e-17 Coffee consumption (cups per day); CRC cis rs3820068 0.603 rs72647118 chr1:15956535 G/T cg13390004 chr1:15929781 NA 0.5 7.08 0.36 8.59e-12 Systolic blood pressure; CRC cis rs539096 0.624 rs603542 chr1:44079411 T/C cg12908607 chr1:44402522 ARTN -0.37 -6.68 -0.35 1.04e-10 Intelligence (multi-trait analysis); CRC cis rs1552172 0.821 rs9286836 chr1:145588536 C/T cg11743829 chr1:145714124 CD160 0.38 5.92 0.31 8.01e-9 Breast cancer; CRC cis rs2730245 0.527 rs2788470 chr7:158649801 G/T cg24397884 chr7:158709396 WDR60 0.87 10.17 0.49 2.62e-21 Height; CRC cis rs763014 1.000 rs763014 chr16:675680 T/C cg02475695 chr16:616220 NHLRC4 0.46 7.46 0.38 8e-13 Height; CRC cis rs1129187 0.755 rs2274514 chr6:42934500 C/T cg26304593 chr6:42947056 PEX6 -0.45 -6.57 -0.34 1.96e-10 Alzheimer's disease in APOE e4+ carriers; CRC cis rs12594515 1.000 rs8031128 chr15:45988528 C/G cg01629716 chr15:45996671 NA 0.41 8.46 0.42 9.03e-16 Waist circumference;Weight; CRC cis rs2243480 1.000 rs36033484 chr7:65390558 T/G cg18252515 chr7:66147081 NA -1.07 -12.34 -0.56 5.05e-29 Diabetic kidney disease; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg04608317 chr7:117824414 NAA38 0.36 6.12 0.32 2.59e-9 Liver disease severity in Alagille syndrome; CRC trans rs1728785 1.000 rs1728764 chr16:68572292 G/C cg04657470 chr2:198365150 HSPE1;HSPD1 0.58 6.97 0.36 1.72e-11 Ulcerative colitis; CRC cis rs13191362 0.935 rs7763118 chr6:162954720 A/G cg21926612 chr6:163149169 PACRG;PARK2 0.79 10.19 0.49 2.17e-21 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs2072499 0.778 rs2247476 chr1:156190280 C/A cg24450063 chr1:156163899 SLC25A44 1.05 16.33 0.67 2.59e-44 Testicular germ cell tumor; CRC cis rs4713118 0.824 rs9468225 chr6:27745719 T/G cg19041857 chr6:27730383 NA -0.45 -6.08 -0.32 3.26e-9 Parkinson's disease; CRC cis rs6834538 0.500 rs17668047 chr4:113422830 T/A cg10021238 chr4:113569128 MIR367;LARP7 -0.37 -5.8 -0.3 1.55e-8 Free thyroxine concentration; CRC cis rs1448094 0.512 rs61930862 chr12:86246567 A/G cg25456477 chr12:86230367 RASSF9 0.34 5.99 0.31 5.54e-9 Major depressive disorder; CRC cis rs950169 0.881 rs34591918 chr15:84950833 C/T cg17507749 chr15:85114479 UBE2QP1 0.74 10.59 0.5 9.91e-23 Schizophrenia; CRC cis rs17095355 1.000 rs12569906 chr10:111706856 A/T cg00817464 chr10:111662876 XPNPEP1 -0.61 -8.21 -0.41 4.95e-15 Biliary atresia; CRC cis rs12898370 0.641 rs11632999 chr15:77436995 T/G cg05673287 chr15:77411982 SGK269 -0.54 -7.09 -0.36 8.02e-12 Risky sexual behaviors (alcohol dependence interaction); CRC trans rs7395662 0.591 rs4882012 chr11:48560597 T/A cg03929089 chr4:120376271 NA -0.46 -6.53 -0.34 2.51e-10 HDL cholesterol; CRC cis rs2732480 0.500 rs2932093 chr12:48648271 G/T cg04545296 chr12:48745243 ZNF641 0.34 5.82 0.31 1.43e-8 Hemoglobin concentration;Red blood cell count;Hematocrit; CRC cis rs11123170 0.543 rs35222158 chr2:113986629 C/T cg11763394 chr2:113992921 PAX8;LOC440839;LOC654433 0.5 5.88 0.31 9.98e-9 Renal function-related traits (BUN); CRC cis rs769267 0.931 rs2965193 chr19:19454828 G/A cg20644253 chr19:19431407 KIAA0892;SF4 -0.41 -5.78 -0.3 1.76e-8 Tonsillectomy; CRC cis rs9322193 0.962 rs9689242 chr6:150109106 T/C cg07701084 chr6:150067640 NUP43 0.47 6.61 0.34 1.51e-10 Lung cancer; CRC cis rs2635047 1.000 rs2277717 chr18:44702718 C/A cg19077165 chr18:44547161 KATNAL2 -0.46 -7.45 -0.38 8.1e-13 Educational attainment; CRC cis rs2180341 0.711 rs4371861 chr6:127568447 G/T cg24812749 chr6:127587940 RNF146 0.53 7.58 0.39 3.62e-13 Breast cancer; CRC cis rs10504229 0.593 rs74760806 chr8:58024785 C/T cg02725872 chr8:58115012 NA -0.44 -6.61 -0.34 1.51e-10 Developmental language disorder (linguistic errors); CRC trans rs7615952 0.546 rs11718647 chr3:125352022 G/A cg02007433 chr3:129722099 NA -0.49 -6.22 -0.32 1.48e-9 Blood pressure (smoking interaction); CRC trans rs925098 0.577 rs2724470 chr4:17996046 A/G cg25937148 chr3:43147320 C3orf39 -0.43 -6.51 -0.34 2.8e-10 Birth weight;Height; CRC cis rs8141529 0.843 rs1065497 chr22:29279991 C/T cg15103426 chr22:29168792 CCDC117 0.45 5.92 0.31 8.28e-9 Lymphocyte counts; CRC cis rs12410462 0.681 rs6682883 chr1:227635598 G/A cg04117972 chr1:227635322 NA 0.86 8.96 0.44 2.39e-17 Major depressive disorder; CRC cis rs9549367 0.789 rs34989271 chr13:113894766 G/A cg00898013 chr13:113819073 PROZ -0.45 -6.37 -0.33 6.36e-10 Platelet distribution width; CRC cis rs28386778 0.933 rs2665801 chr17:61952100 C/T cg23090583 chr17:61904693 PSMC5;FTSJ3 1.02 19.41 0.73 1.76e-56 Prudent dietary pattern; CRC cis rs62064224 0.714 rs11657299 chr17:30634951 G/A cg21839984 chr17:30846986 MYO1D -0.34 -5.89 -0.31 9.69e-9 Schizophrenia; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg25290657 chr19:17186505 HAUS8;MYO9B 0.45 6.24 0.33 1.33e-9 Anxiety disorder; CRC cis rs73200209 0.912 rs61935844 chr12:116617887 A/G cg01776926 chr12:116560359 MED13L -0.48 -5.82 -0.31 1.43e-8 Total body bone mineral density; CRC cis rs1799949 0.965 rs35954893 chr17:41333786 A/G cg05368731 chr17:41323189 NBR1 0.68 10.42 0.5 3.68e-22 Menopause (age at onset); CRC cis rs9467711 0.606 rs9379858 chr6:26367689 T/C cg16898833 chr6:26189333 HIST1H4D 0.76 6.58 0.34 1.88e-10 Autism spectrum disorder or schizophrenia; CRC cis rs34864796 0.547 rs200476 chr6:27768348 A/T cg26587870 chr6:27730563 NA -0.5 -6.88 -0.35 2.96e-11 Lung function (FEV1);Lung function (FEV1/FVC);Lung function (FVC); CRC cis rs892961 0.932 rs67415822 chr17:75412678 A/G cg05865280 chr17:75406074 SEPT9 0.63 14.51 0.62 3.27e-37 Airflow obstruction; CRC cis rs9322193 0.923 rs4421206 chr6:150004027 A/C cg05861140 chr6:150128134 PCMT1 -0.36 -5.86 -0.31 1.15e-8 Lung cancer; CRC cis rs12497850 0.931 rs7431710 chr3:48935583 G/A cg07636037 chr3:49044803 WDR6 1.03 18.4 0.71 1.66e-52 Parkinson's disease; CRC cis rs2032447 0.831 rs9467664 chr6:26021813 A/T cg18357526 chr6:26021779 HIST1H4A 0.79 11.98 0.55 1.1e-27 Intelligence (multi-trait analysis); CRC cis rs57221529 0.766 rs1399381 chr5:589853 G/T cg17948913 chr5:572064 NA 0.55 6.2 0.32 1.71e-9 Lung disease severity in cystic fibrosis; CRC trans rs4873772 0.834 rs6986054 chr8:48574138 C/T cg05343739 chr1:154731938 KCNN3 0.34 6.05 0.32 3.89e-9 Lobe attachment (rater-scored or self-reported); CRC trans rs66887589 0.934 rs4834792 chr4:120555696 T/A cg25214090 chr10:38739885 LOC399744 -0.42 -6.62 -0.34 1.5e-10 Diastolic blood pressure; CRC cis rs7666738 0.791 rs1967978 chr4:98966152 T/C cg05340658 chr4:99064831 C4orf37 0.61 9.45 0.46 6.55e-19 Colonoscopy-negative controls vs population controls; CRC cis rs6933660 0.745 rs9397405 chr6:151736084 G/T cg10883421 chr6:151773342 RMND1;C6orf211 0.71 12.45 0.57 2.06e-29 Menarche (age at onset); CRC trans rs7615952 1.000 rs7616044 chr3:125649354 G/C cg21747405 chr11:67723411 NA -0.43 -6.07 -0.32 3.52e-9 Blood pressure (smoking interaction); CRC cis rs9322193 0.809 rs9479808 chr6:150072464 A/T cg00933542 chr6:150070202 PCMT1 0.32 6.55 0.34 2.23e-10 Lung cancer; CRC trans rs12599106 0.709 rs1501462 chr16:34964515 A/T cg05064044 chr6:292385 DUSP22 -0.73 -10.48 -0.5 2.3e-22 Menopause (age at onset); CRC cis rs7804356 1.000 rs7791513 chr7:26893357 A/C cg03456212 chr7:26904342 SKAP2 -0.49 -5.63 -0.3 3.96e-8 Type 1 diabetes; CRC cis rs68170813 0.559 rs78440378 chr7:106962782 C/A cg02696742 chr7:106810147 HBP1 -0.56 -6.07 -0.32 3.45e-9 Coronary artery disease; CRC cis rs2976388 0.609 rs2164308 chr8:143785659 A/G cg15511327 chr8:143859410 LYNX1 -0.42 -7.36 -0.38 1.45e-12 Urinary tract infection frequency; CRC cis rs7618915 0.547 rs6768697 chr3:52703615 C/T cg18099408 chr3:52552593 STAB1 -0.44 -7.16 -0.37 5.27e-12 Bipolar disorder; CRC cis rs1555322 0.530 rs6060341 chr20:33863633 C/T cg13662093 chr20:33865505 NA -0.48 -6.32 -0.33 8.31e-10 Attention deficit hyperactivity disorder; CRC cis rs853679 0.517 rs4713152 chr6:28137454 G/A cg21251018 chr6:28226885 NKAPL 0.48 6.17 0.32 2.02e-9 Depression; CRC cis rs362272 0.545 rs3135146 chr4:3307638 C/G cg14583973 chr4:3374767 RGS12 -0.27 -5.61 -0.3 4.36e-8 Serum sulfate level; CRC cis rs13191362 1.000 rs35575481 chr6:163007746 T/A cg21926612 chr6:163149169 PACRG;PARK2 0.79 10.93 0.52 6.15e-24 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC trans rs7395662 0.857 rs3902433 chr11:48733324 C/T cg21153622 chr11:89784906 NA 0.46 7.41 0.38 1.06e-12 HDL cholesterol; CRC cis rs12681288 0.676 rs2701923 chr8:994605 A/G cg04851639 chr8:1020857 NA -0.39 -8.17 -0.41 6.76e-15 Schizophrenia; CRC cis rs3106136 0.967 rs17310526 chr4:95222227 G/A cg11021082 chr4:95130006 SMARCAD1 -0.46 -7.09 -0.36 8.28e-12 Capecitabine sensitivity; CRC cis rs9368481 0.594 rs2636425 chr6:26799460 A/G cg12292205 chr6:26970375 C6orf41 0.61 9.82 0.48 3.81e-20 Autism spectrum disorder or schizophrenia; CRC cis rs9399135 0.967 rs2327580 chr6:135364417 A/C cg24558204 chr6:135376177 HBS1L 0.49 7.75 0.39 1.18e-13 Red blood cell count; CRC cis rs9368481 0.547 rs2093303 chr6:26864406 C/T cg18867708 chr6:26865862 GUSBL1 0.42 6.17 0.32 1.99e-9 Autism spectrum disorder or schizophrenia; CRC cis rs3858526 0.514 rs1530973 chr11:5861449 C/T cg26762873 chr11:5879799 OR52E8 -0.47 -7.03 -0.36 1.21e-11 DNA methylation (variation); CRC cis rs4713118 0.662 rs156744 chr6:27967274 G/A cg12273811 chr6:28175739 NA 0.6 8.55 0.43 4.66e-16 Parkinson's disease; CRC cis rs17739794 0.677 rs17739674 chr8:801584 G/T cg20652464 chr8:752313 NA -0.32 -5.76 -0.3 1.94e-8 Clozapine-induced cytotoxicity; CRC cis rs875971 0.540 rs4717275 chr7:65265180 C/T cg02869306 chr7:64672164 INTS4L1 0.34 5.65 0.3 3.42e-8 Aortic root size; CRC cis rs11628318 0.614 rs7154538 chr14:103068112 A/G cg08075719 chr14:103021372 NA -0.63 -7.52 -0.38 5.2e-13 Platelet count; CRC cis rs7568498 0.564 rs9287807 chr2:161915361 T/C cg08807892 chr2:162101083 NA -0.43 -5.67 -0.3 3.16e-8 Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 3 peripheral neuropathy); CRC cis rs1395 0.744 rs11126936 chr2:27483101 A/C cg23587288 chr2:27483067 SLC30A3 0.38 6.4 0.33 5.43e-10 Blood metabolite levels; CRC cis rs7618915 0.501 rs7611731 chr3:52692721 T/C cg05573699 chr3:52720067 GNL3;PBRM1 -0.48 -7.01 -0.36 1.36e-11 Bipolar disorder; CRC cis rs7940866 0.838 rs10750455 chr11:130800330 C/T cg12179176 chr11:130786555 SNX19 0.62 8.9 0.44 3.73e-17 Schizophrenia; CRC cis rs2457480 0.516 rs11598966 chr10:44641416 C/T cg09554077 chr10:44749378 NA 0.47 6.11 0.32 2.88e-9 Coronary artery disease; CRC cis rs367615 0.704 rs11747622 chr5:108844720 G/A cg17395555 chr5:108820864 NA 0.46 9.32 0.46 1.78e-18 Colorectal cancer (SNP x SNP interaction); CRC cis rs58688157 0.705 rs7112149 chr11:595890 G/A cg03909863 chr11:638404 DRD4 -0.53 -7.14 -0.37 6.12e-12 Systemic lupus erythematosus; CRC cis rs951366 0.764 rs823141 chr1:205741426 T/C cg07167872 chr1:205819463 PM20D1 0.78 12.17 0.56 2.2e-28 Menarche (age at onset); CRC cis rs5753618 0.583 rs5753615 chr22:31828027 T/C cg22777020 chr22:31556080 RNF185 0.49 5.91 0.31 8.42e-9 Colorectal cancer; CRC cis rs9611565 0.625 rs73178625 chr22:41928320 G/C cg03806693 chr22:41940476 POLR3H -1.11 -15.16 -0.64 9.65e-40 Vitiligo; CRC cis rs1348850 0.914 rs4893823 chr2:178285811 C/T cg22681709 chr2:178499509 PDE11A 0.39 7.21 0.37 3.9e-12 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs66573146 0.656 rs56094305 chr4:6956086 C/T cg00086871 chr4:6988644 TBC1D14 0.86 8.28 0.42 3.15e-15 Granulocyte percentage of myeloid white cells; CRC cis rs7632954 0.967 rs6791290 chr3:8528727 C/G cg03495237 chr3:8533978 NA 0.35 5.8 0.3 1.56e-8 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC trans rs1005277 0.579 rs2472173 chr10:38374638 G/A cg11292332 chr7:45801988 SEPT13 -0.35 -6.21 -0.32 1.61e-9 Extrinsic epigenetic age acceleration; CRC cis rs9457247 0.565 rs55873403 chr6:167511800 C/T cg07741184 chr6:167504864 NA 0.48 7.95 0.4 3.03e-14 Crohn's disease; CRC trans rs2243480 1.000 rs316307 chr7:65570171 C/T cg10756647 chr7:56101905 PSPH 0.74 7.79 0.39 8.68e-14 Diabetic kidney disease; CRC cis rs4664293 1.000 rs6745766 chr2:160454795 G/A cg08347373 chr2:160653686 CD302 -0.45 -7.31 -0.37 2.02e-12 Monocyte percentage of white cells; CRC cis rs9311474 0.629 rs4282054 chr3:52566065 T/C cg10802521 chr3:52805072 NEK4 -0.42 -6.65 -0.34 1.25e-10 Electroencephalogram traits; CRC trans rs10243593 0.673 rs10272641 chr7:40089932 C/G cg13911576 chr9:84174038 NA 0.37 6.5 0.34 3.05e-10 Lymphocyte counts; CRC cis rs9807989 0.524 rs6543126 chr2:103027104 G/A cg03938978 chr2:103052716 IL18RAP 0.59 10.17 0.49 2.73e-21 Asthma; CRC cis rs798554 0.797 rs798491 chr7:2800521 A/G cg19717773 chr7:2847554 GNA12 -0.47 -6.55 -0.34 2.16e-10 Height; CRC cis rs6952808 0.594 rs3778969 chr7:2139990 A/G cg02951883 chr7:2050386 MAD1L1 0.68 10.63 0.51 6.98e-23 Bipolar disorder and schizophrenia; CRC cis rs763014 1.000 rs2269558 chr16:682250 C/T cg04497992 chr16:616212 NHLRC4 0.42 6.63 0.34 1.36e-10 Height; CRC cis rs60871478 1.000 rs4721124 chr7:823761 T/C cg04727924 chr7:799746 HEATR2 -0.43 -6.42 -0.33 4.89e-10 Cerebrospinal P-tau181p levels; CRC cis rs3540 0.960 rs8030299 chr15:91026459 G/A cg22089800 chr15:90895588 ZNF774 0.48 7.72 0.39 1.39e-13 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg10723024 chr11:62494009 HNRNPUL2 0.45 6.3 0.33 9.66e-10 Response to antipsychotic treatment; CRC cis rs28386778 0.897 rs716880 chr17:61902822 C/G cg07362569 chr17:61921086 SMARCD2 0.38 5.95 0.31 6.87e-9 Prudent dietary pattern; CRC cis rs4713118 0.662 rs464312 chr6:27967591 T/A cg15845792 chr6:28175446 NA 0.8 11.85 0.55 3.12e-27 Parkinson's disease; CRC cis rs933688 1.000 rs1035476 chr5:90745976 C/T cg02339078 chr5:90679543 LOC100129716;ARRDC3 0.9 13.86 0.61 1.03e-34 Smoking behavior; CRC trans rs9956878 0.555 rs8085188 chr18:73544676 A/G cg17152658 chr8:132916406 EFR3A -0.42 -6.83 -0.35 4.13e-11 Obesity-related traits; CRC cis rs11608355 0.515 rs2241204 chr12:109972037 G/A cg05360138 chr12:110035743 NA 0.77 8.63 0.43 2.72e-16 Neuroticism; CRC cis rs1552244 0.938 rs66915020 chr3:10110174 A/G cg18598329 chr3:10140678 FANCD2;C3orf24 -0.87 -12.07 -0.55 5.3e-28 Alzheimer's disease; CRC cis rs6496667 0.657 rs8026265 chr15:90885870 A/G cg04176472 chr15:90893244 GABARAPL3 0.56 6.69 0.35 9.64e-11 Rheumatoid arthritis; CRC cis rs7043114 0.525 rs10820969 chr9:95106678 G/C cg13798575 chr9:95087839 CENPP;NOL8 -0.4 -6.01 -0.31 5e-9 Height; CRC cis rs2153535 0.580 rs1335637 chr6:8465101 A/G cg07606381 chr6:8435919 SLC35B3 0.67 10.7 0.51 4.01e-23 Motion sickness; CRC cis rs2276314 0.857 rs4799408 chr18:33588982 C/T cg19628046 chr18:33552617 C18orf21 -0.49 -7.1 -0.36 7.96e-12 Endometriosis;Drug-induced torsades de pointes; CRC cis rs9368481 0.594 rs7768814 chr6:26892036 C/A cg12292205 chr6:26970375 C6orf41 0.63 9.98 0.48 1.12e-20 Autism spectrum disorder or schizophrenia; CRC cis rs9896933 0.830 rs113051447 chr17:80791806 A/G cg15369054 chr17:80825471 TBCD 0.46 5.78 0.3 1.74e-8 Bone mineral accretion in asthma (oral corticosteroid dose interaction); CRC cis rs9322193 0.884 rs11155679 chr6:150080017 T/C cg05861140 chr6:150128134 PCMT1 -0.42 -6.48 -0.34 3.31e-10 Lung cancer; CRC cis rs7811142 1.000 rs6975514 chr7:100056220 T/C cg00814883 chr7:100076585 TSC22D4 -0.75 -9.44 -0.46 6.97e-19 Platelet count; CRC cis rs9467773 1.000 rs6925703 chr6:26521589 G/A cg09904177 chr6:26538194 HMGN4 0.86 14.68 0.63 7.34e-38 Intelligence (multi-trait analysis); CRC cis rs9905704 0.647 rs10221208 chr17:57047885 T/C cg12560992 chr17:57184187 TRIM37 0.62 9.5 0.46 4.61e-19 Testicular germ cell tumor; CRC cis rs1712517 0.836 rs11191649 chr10:105067037 T/C cg05636881 chr10:105038444 INA 0.43 7.39 0.38 1.19e-12 Migraine; CRC cis rs7945718 0.875 rs9888179 chr11:12782601 G/T cg25843174 chr11:12811716 TEAD1 0.47 9.12 0.45 7.63e-18 Educational attainment (years of education); CRC cis rs6696846 0.777 rs9651228 chr1:205049383 A/G cg00857998 chr1:205179979 DSTYK 0.41 5.77 0.3 1.79e-8 Red blood cell count; CRC cis rs4332037 0.950 rs62442895 chr7:1936938 G/A cg23422044 chr7:1970798 MAD1L1 -0.61 -7.49 -0.38 6.53e-13 Bipolar disorder; CRC cis rs910316 1.000 rs175443 chr14:75601963 C/T cg03030879 chr14:75389066 RPS6KL1 0.47 7.41 0.38 1.1e-12 Height; CRC cis rs6743376 0.556 rs2515402 chr2:113820580 C/A cg09040174 chr2:113837401 NA 0.4 5.84 0.31 1.22e-8 Inflammatory biomarkers; CRC cis rs7849270 0.801 rs10819475 chr9:131930840 G/A cg13538475 chr9:131942899 NA 0.31 5.85 0.31 1.19e-8 Blood metabolite ratios; CRC cis rs6724607 0.905 rs10173771 chr2:191439248 T/C cg10560079 chr2:191398806 TMEM194B 0.48 6.82 0.35 4.34e-11 Pulse pressure; CRC cis rs60843830 1.000 rs56321614 chr2:268191 G/T cg25945732 chr2:264204 ACP1;SH3YL1 0.71 11.67 0.54 1.42e-26 Spherical equivalent (joint analysis main effects and education interaction); CRC cis rs425277 1.000 rs262651 chr1:2091397 A/G cg24578937 chr1:2090814 PRKCZ 0.66 11.75 0.54 7.6e-27 Height; CRC trans rs3733585 0.699 rs6449178 chr4:9968684 A/G cg26043149 chr18:55253948 FECH 0.5 7.7 0.39 1.65e-13 Cleft plate (environmental tobacco smoke interaction); CRC cis rs67340775 0.541 rs200974 chr6:27855845 A/G cg15786705 chr6:28176104 NA 0.56 5.65 0.3 3.39e-8 Lung cancer in ever smokers; CRC cis rs9549328 0.564 rs34556022 chr13:113617437 G/A cg17524180 chr13:113633600 MCF2L 0.52 9.5 0.46 4.44e-19 Systolic blood pressure; CRC cis rs11585357 0.501 rs4262593 chr1:17594263 T/C cg08277548 chr1:17600880 PADI3 -0.63 -7.3 -0.37 2.24e-12 Hair shape; CRC cis rs1005277 0.579 rs1614236 chr10:38502996 C/T cg25517755 chr10:38738941 LOC399744 -0.42 -5.98 -0.31 5.66e-9 Extrinsic epigenetic age acceleration; CRC cis rs10493773 0.502 rs12066742 chr1:86081149 A/G cg17807903 chr1:86174739 ZNHIT6 -0.47 -9.01 -0.44 1.71e-17 Urate levels in overweight individuals; CRC cis rs9916302 0.706 rs8069074 chr17:37685401 C/T cg03013999 chr17:37608204 MED1 -0.44 -5.62 -0.3 4.12e-8 Glomerular filtration rate (creatinine); CRC cis rs9291683 0.507 rs3775940 chr4:10025163 A/T cg00071950 chr4:10020882 SLC2A9 0.61 10.94 0.52 5.58e-24 Bone mineral density; CRC cis rs735539 0.645 rs1052209 chr13:21216850 C/T cg04906043 chr13:21280425 IL17D -0.4 -5.91 -0.31 8.75e-9 Dental caries; CRC cis rs4819052 0.851 rs3673 chr21:46681775 C/T cg02159808 chr21:46707872 POFUT2;LOC642852 0.48 6.51 0.34 2.86e-10 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs854572 0.870 rs757158 chr7:94955528 C/T cg20119798 chr7:94954144 PON1 -0.69 -11.41 -0.53 1.29e-25 Paraoxonase activity; CRC cis rs728616 0.867 rs61860041 chr10:81944331 G/A cg11900509 chr10:81946545 ANXA11 -0.71 -7.16 -0.37 5.2e-12 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs10992471 0.676 rs13286566 chr9:95473178 C/T cg14631576 chr9:95140430 CENPP -0.39 -6.95 -0.36 1.98e-11 Visceral adipose tissue/subcutaneous adipose tissue ratio; CRC trans rs1005277 0.602 rs1780141 chr10:38504299 T/C cg23533926 chr12:111358616 MYL2 -0.56 -8.67 -0.43 1.97e-16 Extrinsic epigenetic age acceleration; CRC cis rs10504229 1.000 rs17805326 chr8:58169533 A/C cg21724239 chr8:58056113 NA 0.4 5.79 0.3 1.66e-8 Developmental language disorder (linguistic errors); CRC cis rs534126 0.736 rs10239488 chr7:142949599 C/G cg04039957 chr7:143013207 CLCN1 0.34 5.68 0.3 2.96e-8 Cancer; CRC cis rs736408 0.545 rs6445529 chr3:52662722 T/A cg08222913 chr3:52553049 STAB1 -0.33 -6.26 -0.33 1.2e-9 Bipolar disorder; CRC cis rs7923609 1.000 rs7910927 chr10:65138910 T/G cg08743896 chr10:65200160 JMJD1C -0.4 -5.74 -0.3 2.14e-8 Educational attainment;Liver enzyme levels (alkaline phosphatase); CRC trans rs9914544 0.762 rs4322727 chr17:18798573 A/T cg04702396 chr17:15466718 FAM18B2 -0.47 -7.25 -0.37 3.07e-12 Educational attainment (years of education); CRC cis rs9311474 0.629 rs13081028 chr3:52555316 G/A cg08222913 chr3:52553049 STAB1 -0.41 -8.22 -0.41 4.91e-15 Electroencephalogram traits; CRC trans rs877282 0.945 rs11253396 chr10:789754 C/T cg22713356 chr15:30763199 NA 1.34 16.68 0.68 1.08e-45 Uric acid levels; CRC cis rs10504229 0.728 rs59266065 chr8:58156236 A/G cg05313129 chr8:58192883 C8orf71 -0.48 -6.25 -0.33 1.29e-9 Developmental language disorder (linguistic errors); CRC cis rs6546324 0.625 rs11900280 chr2:67840401 T/C cg15745817 chr2:67799979 NA -0.57 -9.66 -0.47 1.37e-19 Endometriosis; CRC cis rs2857891 0.909 rs56372435 chr11:6938658 T/C cg26870460 chr11:6947759 ZNF215 0.58 6.05 0.32 3.85e-9 Response to cytadine analogues (cytosine arabinoside); CRC cis rs8014204 0.604 rs2159906 chr14:75390912 G/T cg03030879 chr14:75389066 RPS6KL1 -0.7 -11.88 -0.55 2.59e-27 Caffeine consumption; CRC cis rs7917772 0.503 rs7914389 chr10:104295402 T/C cg11453585 chr10:104263688 ACTR1A;SUFU 0.91 17.49 0.69 6.57e-49 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC cis rs4474465 0.850 rs4944205 chr11:78227790 T/A cg27205649 chr11:78285834 NARS2 0.49 6.1 0.32 2.93e-9 Alzheimer's disease (survival time); CRC cis rs17270561 0.636 rs10946793 chr6:25699999 A/G cg17691542 chr6:26056736 HIST1H1C 0.62 7.59 0.39 3.43e-13 Iron status biomarkers; CRC cis rs736408 0.716 rs2239549 chr3:52823126 C/T cg18099408 chr3:52552593 STAB1 -0.37 -5.7 -0.3 2.63e-8 Bipolar disorder; CRC cis rs1150668 0.796 rs1005125 chr6:28367355 G/A cg21251018 chr6:28226885 NKAPL 0.52 8.87 0.44 4.61e-17 Pubertal anthropometrics; CRC cis rs4974559 0.740 rs11933854 chr4:1315172 G/A cg02980000 chr4:1222292 CTBP1 0.45 5.68 0.3 3.02e-8 Systolic blood pressure; CRC cis rs9549367 0.789 rs9549365 chr13:113907391 C/T cg18105134 chr13:113819100 PROZ 0.73 10.61 0.51 7.85e-23 Platelet distribution width; CRC cis rs6665290 0.904 rs3795449 chr1:227181838 T/G cg10327440 chr1:227177885 CDC42BPA -1.03 -23.09 -0.79 8.18e-71 Myeloid white cell count; CRC cis rs1552244 1.000 rs6442150 chr3:10122575 T/C cg10729496 chr3:10149963 C3orf24 0.55 7.26 0.37 2.73e-12 Alzheimer's disease; CRC cis rs12155623 0.592 rs12682003 chr8:49865454 G/T cg00325661 chr8:49890786 NA 0.4 7.03 0.36 1.19e-11 Sudden cardiac arrest; CRC cis rs473651 0.935 rs472357 chr2:239355454 A/G cg18131467 chr2:239335373 ASB1 -1.02 -23.18 -0.79 3.8e-71 Multiple system atrophy; CRC cis rs7666738 0.830 rs9999200 chr4:99030690 A/C cg05340658 chr4:99064831 C4orf37 0.61 9.42 0.46 8.23e-19 Colonoscopy-negative controls vs population controls; CRC cis rs826838 0.967 rs1719853 chr12:39128515 A/G cg13010199 chr12:38710504 ALG10B -0.41 -5.86 -0.31 1.11e-8 Heart rate; CRC trans rs10802346 0.545 rs4607841 chr1:246373295 T/C cg22732515 chr19:44031385 ETHE1 0.68 10.28 0.49 1.09e-21 Fractional exhaled nitric oxide (childhood); CRC cis rs5769765 0.908 rs9616217 chr22:50318946 C/T cg22709217 chr22:50311962 ALG12;CRELD2 -1.08 -16.4 -0.67 1.29e-44 Schizophrenia; CRC cis rs10504229 0.683 rs79262965 chr8:58129826 G/T cg22535103 chr8:58192502 C8orf71 -0.73 -8.34 -0.42 2.06e-15 Developmental language disorder (linguistic errors); CRC cis rs597539 0.617 rs598353 chr11:68635770 C/A cg06112835 chr11:68658793 MRPL21 0.43 6.88 0.35 3.11e-11 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs995000 0.899 rs11207974 chr1:62949960 T/C cg19896129 chr1:63156450 NA 0.41 6.2 0.32 1.68e-9 Triglyceride levels; CRC cis rs9908102 0.740 rs56131975 chr17:12912870 T/C cg26162695 chr17:12921313 ELAC2 0.43 5.85 0.31 1.17e-8 Schizophrenia; CRC cis rs951366 0.528 rs1172198 chr1:205662718 C/T cg07157834 chr1:205819609 PM20D1 0.73 10.44 0.5 3.2800000000000002e-22 Menarche (age at onset); CRC cis rs11758351 1.000 rs11758351 chr6:26203910 T/G cg22723502 chr6:26240528 HIST1H4F -0.39 -6.16 -0.32 2.1e-9 Gout;Renal underexcretion gout; CRC trans rs2228479 0.850 rs62054611 chr16:89817017 T/C cg24644049 chr4:85504048 CDS1 0.9 7.46 0.38 7.69e-13 Skin colour saturation; CRC cis rs7811142 0.775 rs6946768 chr7:99954393 G/A cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.56 6.91 0.36 2.5e-11 Platelet count; CRC trans rs2303319 0.504 rs62189051 chr2:162622318 G/A cg04551154 chr10:95462393 C10orf4 -0.74 -6.34 -0.33 7.76e-10 Cognitive function; CRC cis rs3790455 0.560 rs1171558 chr1:156452093 G/A cg14087168 chr1:156450669 MEF2D -0.37 -6.03 -0.32 4.45e-9 Migraine; CRC cis rs9916302 0.904 rs9892055 chr17:37510402 C/T cg03013999 chr17:37608204 MED1 -0.47 -7.24 -0.37 3.23e-12 Glomerular filtration rate (creatinine); CRC cis rs2153535 0.580 rs1932285 chr6:8477719 T/G cg21535247 chr6:8435926 SLC35B3 0.5 7.52 0.38 5.18e-13 Motion sickness; CRC cis rs10504229 0.683 rs66730544 chr8:58127280 A/T cg24829409 chr8:58192753 C8orf71 -0.55 -8.03 -0.4 1.71e-14 Developmental language disorder (linguistic errors); CRC cis rs6502050 0.777 rs7406162 chr17:80086386 C/T cg25804541 chr17:80189381 SLC16A3 0.31 5.9 0.31 8.92e-9 Life satisfaction; CRC cis rs515186 1 rs515186 chr6:36397492 T/G cg07856975 chr6:36356162 ETV7 0.4 5.91 0.31 8.7e-9 Mean platelet volume; CRC cis rs921968 0.643 rs497983 chr2:219415189 A/G cg02176678 chr2:219576539 TTLL4 0.49 7.97 0.4 2.72e-14 Mean corpuscular hemoglobin concentration; CRC cis rs9341808 0.558 rs2322635 chr6:80897210 A/G cg08355045 chr6:80787529 NA 0.37 6.27 0.33 1.14e-9 Sitting height ratio; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg21194723 chr11:60681294 TMEM109 0.43 6.2 0.32 1.65e-9 Response to antipsychotic treatment; CRC cis rs10771431 0.597 rs3759275 chr12:9353828 A/T cg22349387 chr12:9600060 DDX12 -0.36 -5.65 -0.3 3.41e-8 Breast size; CRC cis rs6504622 0.875 rs3785888 chr17:45005703 C/T cg16759221 chr17:45003025 GOSR2 0.46 6.88 0.35 3.08e-11 Orofacial clefts; CRC cis rs6951245 0.554 rs11544331 chr7:1131411 C/T cg07217954 chr7:1067459 C7orf50 0.51 6.04 0.32 4.07e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs6500395 0.925 rs12920170 chr16:48701530 A/G cg04672837 chr16:48644449 N4BP1 -0.45 -6.63 -0.34 1.38e-10 Response to tocilizumab in rheumatoid arthritis; CRC cis rs7572644 0.662 rs13402420 chr2:28271435 T/G cg27432699 chr2:27873401 GPN1 -0.4 -5.61 -0.3 4.19e-8 Response to carboplatin and paclitaxel in ovarian cancer (Caspase 3/7 EC50); CRC cis rs2732480 0.557 rs2732454 chr12:48719677 T/C cg24011408 chr12:48396354 COL2A1 0.45 6.21 0.32 1.6e-9 Hemoglobin concentration;Red blood cell count;Hematocrit; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg16140913 chr4:8430389 ACOX3 0.46 6.48 0.34 3.28e-10 Response to antipsychotic treatment; CRC cis rs5769765 1.000 rs1033665 chr22:50252127 A/G cg02269571 chr22:50332266 NA -0.55 -7.82 -0.4 7.41e-14 Schizophrenia; CRC cis rs10504229 0.683 rs11775506 chr8:58133639 G/T cg02290350 chr8:58132656 NA -0.58 -8.21 -0.41 5e-15 Developmental language disorder (linguistic errors); CRC cis rs208520 0.955 rs28684412 chr6:66979430 A/C cg07460842 chr6:66804631 NA 0.91 11.17 0.52 8.75e-25 Exhaled nitric oxide output; CRC cis rs3772130 0.527 rs2141614 chr3:121590173 G/A cg20356878 chr3:121714668 ILDR1 0.57 10.85 0.51 1.23e-23 Cognitive performance; CRC trans rs3931020 0.720 rs927904 chr1:75260328 A/G cg15593716 chr7:29845970 NA 0.4 6.07 0.32 3.5e-9 Resistin levels; CRC cis rs9322193 0.884 rs7450246 chr6:150023653 C/T cg04369109 chr6:150039330 LATS1 -0.42 -5.79 -0.3 1.6e-8 Lung cancer; CRC cis rs354033 1.000 rs58026905 chr7:149224358 G/A cg24335155 chr7:149193227 ZNF746 0.38 5.86 0.31 1.13e-8 Multiple sclerosis; CRC cis rs1728785 1.000 rs1728765 chr16:68589433 G/A cg02972257 chr16:68554789 NA -0.61 -7.61 -0.39 2.89e-13 Ulcerative colitis; CRC cis rs1005277 0.579 rs1780136 chr10:38501453 A/G cg00409905 chr10:38381863 ZNF37A -0.62 -10.29 -0.49 1.03e-21 Extrinsic epigenetic age acceleration; CRC cis rs1150688 1 rs1150688 chr6:28162780 T/C cg15786705 chr6:28176104 NA 0.48 7.16 0.37 5.19e-12 Autism spectrum disorder or schizophrenia; CRC cis rs11226613 0.568 rs1785878 chr11:104963106 A/G cg04181079 chr11:104896587 CASP1 0.41 5.72 0.3 2.33e-8 Bronchopulmonary dysplasia; CRC cis rs898097 0.841 rs11656358 chr17:80853956 G/A cg15369054 chr17:80825471 TBCD 0.54 8.86 0.44 4.93e-17 Breast cancer; CRC cis rs11122272 0.735 rs2790882 chr1:231532783 A/G cg06096015 chr1:231504339 EGLN1 -0.43 -6.29 -0.33 1e-9 Hemoglobin concentration; CRC cis rs7208859 0.623 rs216446 chr17:28933718 T/G cg01831904 chr17:28903510 LRRC37B2 -0.58 -5.94 -0.31 7.45e-9 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs7552404 1.000 rs11163924 chr1:76132070 A/C cg22875332 chr1:76189707 ACADM -0.69 -9.24 -0.45 3.1e-18 Blood metabolite levels;Acylcarnitine levels; CRC trans rs9291683 0.566 rs13115776 chr4:10040189 C/G cg26043149 chr18:55253948 FECH 0.49 7.42 0.38 1.02e-12 Bone mineral density; CRC cis rs2949837 0.581 rs1542819 chr7:45978059 T/C cg10677697 chr7:45961126 IGFBP3 0.36 6.3 0.33 9.38e-10 Sitting height ratio; CRC cis rs6662572 0.737 rs4573476 chr1:46346721 T/A cg08644498 chr1:46502608 NA 0.44 6.66 0.34 1.12e-10 Blood protein levels; CRC cis rs9325144 0.560 rs10506125 chr12:39120287 C/T cg26384229 chr12:38710491 ALG10B 0.52 7.86 0.4 5.63e-14 Morning vs. evening chronotype; CRC cis rs7739232 0.920 rs41273882 chr6:53517228 A/C cg15658676 chr6:53530538 KLHL31 -0.67 -5.66 -0.3 3.32e-8 Hip circumference adjusted for BMI; CRC trans rs916888 0.773 rs199534 chr17:44824213 T/G cg07870213 chr5:140052090 DND1 1.05 11.42 0.53 1.11e-25 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs7091068 0.671 rs514120 chr10:95404400 G/A cg20715218 chr10:95462985 C10orf4 -0.48 -5.66 -0.3 3.38e-8 Urinary tract infection frequency; CRC cis rs9733 0.628 rs7540874 chr1:150702663 A/C cg15448220 chr1:150897856 SETDB1 0.45 6.41 0.33 5.09e-10 Tonsillectomy; CRC trans rs2840044 1.000 rs7212704 chr17:33898897 C/T cg19694781 chr19:47549865 TMEM160 0.44 6.94 0.36 2.1e-11 Response to radiotherapy in cancer (late toxicity); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg08664617 chr1:155036082 EFNA4 0.39 5.98 0.31 5.75e-9 Liver disease severity in Alagille syndrome; CRC cis rs6714710 0.557 rs17490429 chr2:98449024 G/A cg26665480 chr2:98280029 ACTR1B 0.53 7.27 0.37 2.59e-12 Posterior cortical atrophy and Alzheimer's disease; CRC trans rs6703335 0.870 rs10803142 chr1:243598234 A/G cg01220033 chr9:131419100 WDR34 0.47 6.47 0.34 3.56e-10 Schizophrenia;Schizophrenia, schizoaffective disorder or bipolar disorder; CRC cis rs916888 0.610 rs199444 chr17:44818276 T/C cg15921436 chr17:44337874 NA 0.55 7.06 0.36 1.02e-11 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs4474465 0.850 rs10793330 chr11:78269985 T/C cg27205649 chr11:78285834 NARS2 0.48 6.25 0.33 1.28e-9 Alzheimer's disease (survival time); CRC cis rs12887734 0.566 rs3742366 chr14:104198351 T/C cg08213375 chr14:104286397 PPP1R13B 0.47 7.57 0.39 3.71e-13 Schizophrenia;Autism spectrum disorder or schizophrenia; CRC cis rs780096 0.546 rs2293572 chr2:27728777 C/G cg12000995 chr2:27665139 KRTCAP3 0.31 6.36 0.33 6.63e-10 Total body bone mineral density; CRC cis rs637571 0.522 rs28578718 chr11:65748400 C/A cg17985854 chr11:65770987 BANF1;EIF1AD 0.51 8.66 0.43 2.19e-16 Eosinophil percentage of white cells; CRC cis rs3106136 0.681 rs11097422 chr4:95302982 C/G cg11021082 chr4:95130006 SMARCAD1 0.38 5.66 0.3 3.26e-8 Capecitabine sensitivity; CRC cis rs11190604 0.943 rs7900678 chr10:102229016 T/C cg07080220 chr10:102295463 HIF1AN 0.47 5.83 0.31 1.31e-8 Palmitoleic acid (16:1n-7) levels; CRC cis rs2180341 1.000 rs6910763 chr6:127630925 T/C cg27446573 chr6:127587934 RNF146 0.99 14.65 0.63 8.94e-38 Breast cancer; CRC cis rs1448094 0.817 rs10863122 chr12:86346047 T/C cg02569458 chr12:86230093 RASSF9 0.47 7.98 0.4 2.42e-14 Major depressive disorder; CRC cis rs4474465 0.850 rs7936232 chr11:78266602 A/G cg27205649 chr11:78285834 NARS2 0.49 6.23 0.32 1.41e-9 Alzheimer's disease (survival time); CRC trans rs60843830 1.000 rs3791220 chr2:227066 C/T cg11347411 chr7:150020925 ACTR3C;LRRC61 0.6 9.5 0.46 4.4e-19 Spherical equivalent (joint analysis main effects and education interaction); CRC cis rs11690935 0.959 rs12692970 chr2:172594197 T/C cg13550731 chr2:172543902 DYNC1I2 -1.09 -18.51 -0.71 6.24e-53 Schizophrenia; CRC cis rs3806843 1.000 rs10037757 chr5:140197222 G/T cg19875535 chr5:140030758 IK 0.55 8.87 0.44 4.8e-17 Depressive symptoms (multi-trait analysis); CRC cis rs7937682 0.632 rs57414412 chr11:111769431 G/A cg09085632 chr11:111637200 PPP2R1B 0.94 15.0 0.64 4.09e-39 Primary sclerosing cholangitis; CRC trans rs9929218 0.529 rs8059194 chr16:68749663 C/T cg04657470 chr2:198365150 HSPE1;HSPD1 1.05 21.14 0.76 3.01e-63 Colorectal cancer; CRC cis rs116095464 0.558 rs10059907 chr5:205360 G/C cg22496380 chr5:211416 CCDC127 -0.95 -9.31 -0.46 1.84e-18 Breast cancer; CRC trans rs7615952 1.000 rs9289275 chr3:125648659 A/T cg00769240 chr8:12517080 NA -0.54 -6.41 -0.33 5.08e-10 Blood pressure (smoking interaction); CRC cis rs875971 0.862 rs1983372 chr7:65611351 C/T cg00343986 chr7:65444356 GUSB -0.42 -5.98 -0.31 5.92e-9 Aortic root size; CRC cis rs1552244 0.572 rs2054478 chr3:10172211 C/T cg18598329 chr3:10140678 FANCD2;C3orf24 -0.91 -10.7 -0.51 3.85e-23 Alzheimer's disease; CRC cis rs2380220 0.576 rs4368819 chr6:96031109 T/G cg04719120 chr6:96025338 MANEA 0.73 9.18 0.45 4.77e-18 Behavioural disinhibition (generation interaction); CRC cis rs7131987 0.621 rs6487805 chr12:29457550 A/T cg09582351 chr12:29534625 ERGIC2 0.32 6.93 0.36 2.23e-11 QT interval; CRC cis rs8180040 0.966 rs11130128 chr3:47486632 T/C cg02527881 chr3:46936655 PTH1R 0.38 7.06 0.36 9.69e-12 Colorectal cancer; CRC cis rs13191362 1.000 rs34177053 chr6:163007772 T/C cg21926612 chr6:163149169 PACRG;PARK2 0.74 10.83 0.51 1.37e-23 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs7586879 0.828 rs11675013 chr2:25107208 G/A cg04586622 chr2:25135609 ADCY3 -0.58 -9.9 -0.48 2.2e-20 Body mass index; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg12513308 chr16:66586534 CKLF 0.47 6.73 0.35 7.34e-11 Response to antipsychotic treatment; CRC cis rs10504229 0.683 rs7459958 chr8:58111905 G/T cg05313129 chr8:58192883 C8orf71 -0.42 -5.85 -0.31 1.16e-8 Developmental language disorder (linguistic errors); CRC cis rs17376456 0.825 rs66564678 chr5:93165894 C/T cg25358565 chr5:93447407 FAM172A 1.01 9.99 0.48 1.09e-20 Diabetic retinopathy; CRC cis rs17818399 0.620 rs6739397 chr2:46858321 G/C cg26688816 chr2:46740690 ATP6V1E2 -0.43 -6.46 -0.34 3.88e-10 Height; CRC trans rs4942242 0.663 rs34595450 chr13:44221245 A/G cg19169023 chr15:41853346 TYRO3 -0.62 -8.78 -0.44 9.07e-17 Response to tocilizumab in rheumatoid arthritis; CRC cis rs765787 0.530 rs4238376 chr15:45541887 T/C cg24006582 chr15:45444508 DUOX1 -0.57 -8.63 -0.43 2.62e-16 Uric acid levels; CRC cis rs116095464 0.558 rs112343653 chr5:257174 G/A cg22857025 chr5:266934 NA -1.25 -16.78 -0.68 4.42e-46 Breast cancer; CRC cis rs9560113 0.550 rs1163632 chr13:112231530 T/C cg10483660 chr13:112241077 NA -0.64 -12.72 -0.57 2.03e-30 Menarche (age at onset); CRC cis rs9311474 0.659 rs1133415 chr3:52575831 G/A cg18099408 chr3:52552593 STAB1 -0.56 -10.2 -0.49 2.15e-21 Electroencephalogram traits; CRC cis rs644799 0.625 rs1255177 chr11:95471495 A/G cg03916912 chr11:95522834 CEP57;FAM76B 0.56 8.67 0.43 2e-16 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs853679 0.517 rs34716816 chr6:28046169 C/A cg23161317 chr6:28129485 ZNF389 0.52 6.4 0.33 5.21e-10 Depression; CRC cis rs739401 0.611 rs417957 chr11:3046231 A/G cg05729581 chr11:3078854 CARS -0.58 -8.72 -0.43 1.35e-16 Longevity; CRC cis rs6541297 1.000 rs2352723 chr1:230291868 C/T cg20703242 chr1:230279135 GALNT2 -0.48 -6.89 -0.36 2.76e-11 Coronary artery disease; CRC cis rs889312 0.500 rs702691 chr5:56114526 T/G cg24531977 chr5:56204891 C5orf35 -0.45 -6.89 -0.36 2.85e-11 Breast cancer;Breast cancer (early onset); CRC cis rs9818758 0.556 rs9835439 chr3:49220330 G/C cg00383909 chr3:49044727 WDR6 1.02 10.01 0.48 8.9e-21 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; CRC cis rs7508679 1.000 rs7248104 chr19:7224431 A/G cg09779027 chr19:7224513 INSR 1.09 26.12 0.82 3.15e-82 Hypothyroidism; CRC trans rs2303319 0.504 rs56009150 chr2:162598582 T/C cg03124313 chr19:36036028 GAPDHS;TMEM147 -0.67 -6.0 -0.31 5.21e-9 Cognitive function; CRC cis rs1790761 0.692 rs10896179 chr11:67316928 C/A cg00290607 chr11:67383545 NA 0.38 6.3 0.33 9.51e-10 Mean corpuscular volume; CRC cis rs4919694 1.000 rs12268849 chr10:104737682 G/A cg04362960 chr10:104952993 NT5C2 1.12 10.46 0.5 2.65e-22 Arsenic metabolism; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg06458679 chr21:46974866 NA 0.38 6.12 0.32 2.64e-9 Liver disease severity in Alagille syndrome; CRC cis rs11212617 0.934 rs10890834 chr11:108286443 C/T cg12106634 chr11:108092400 ATM;NPAT 0.43 6.51 0.34 2.82e-10 Response to metformin in type 2 diabetes (glycemic); CRC cis rs68170813 0.559 rs6951639 chr7:106817639 A/G cg02696742 chr7:106810147 HBP1 -0.62 -6.81 -0.35 4.67e-11 Coronary artery disease; CRC cis rs936229 0.749 rs6495127 chr15:75194490 C/T cg14664628 chr15:75095509 CSK -0.85 -14.4 -0.62 8.2e-37 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); CRC cis rs9467711 0.606 rs2073531 chr6:26375256 A/G cg14345882 chr6:26364793 BTN3A2 0.64 5.63 0.3 3.85e-8 Autism spectrum disorder or schizophrenia; CRC cis rs896854 0.654 rs10429443 chr8:95971164 A/G cg09323728 chr8:95962352 TP53INP1 -0.45 -7.46 -0.38 7.88e-13 Type 2 diabetes; CRC cis rs9326248 0.539 rs7120565 chr11:117042949 T/C cg10130564 chr11:117069849 TAGLN 0.32 6.05 0.32 4.04e-9 Blood protein levels; CRC cis rs4308124 0.708 rs10178095 chr2:111972516 C/T cg04571233 chr2:111982156 NA -0.56 -8.24 -0.41 4.22e-15 Vitiligo; CRC cis rs9303280 0.901 rs921650 chr17:38069076 G/A cg20243544 chr17:37824526 PNMT -0.43 -6.67 -0.35 1.09e-10 Self-reported allergy; CRC cis rs9287719 0.649 rs10202370 chr2:10727043 T/C cg00105475 chr2:10696890 NA 0.44 7.0 0.36 1.43e-11 Prostate cancer; CRC cis rs4836694 0.574 rs4837476 chr9:132937533 T/C cg13414629 chr9:132935646 FREQ 0.44 6.34 0.33 7.71e-10 Alzheimer's disease (cognitive decline); CRC cis rs10540 0.818 rs12806089 chr11:501468 G/A cg15790184 chr11:494944 RNH1 0.6 6.17 0.32 1.95e-9 Body mass index; CRC cis rs11948739 0.501 rs79115810 chr5:130374516 A/G cg08523029 chr5:130500466 HINT1 -0.45 -5.96 -0.31 6.51e-9 Pediatric bone mineral content (hip); CRC cis rs7493 1.000 rs17876123 chr7:95045307 C/A cg20119798 chr7:94954144 PON1 -0.51 -6.48 -0.34 3.3e-10 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs6502050 0.805 rs9898326 chr17:80119582 C/T cg22110888 chr17:80059540 CCDC57 0.4 6.38 0.33 5.96e-10 Life satisfaction; CRC cis rs533581 0.873 rs579740 chr16:88973937 A/G cg05579598 chr16:88989069 CBFA2T3 -0.4 -8.56 -0.43 4.28e-16 Social autistic-like traits; CRC cis rs2204008 0.840 rs7136347 chr12:38453531 G/A cg26384229 chr12:38710491 ALG10B 0.71 9.5 0.46 4.39e-19 Bladder cancer; CRC trans rs916888 0.610 rs199453 chr17:44800946 C/T cg07870213 chr5:140052090 DND1 0.59 7.61 0.39 2.92e-13 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs282587 0.569 rs9604421 chr13:113410493 C/G cg04656015 chr13:113407548 ATP11A 0.61 7.43 0.38 9.63e-13 Glycated hemoglobin levels; CRC cis rs561341 1.000 rs564714 chr17:30318404 C/T cg12193833 chr17:30244370 NA -0.76 -8.88 -0.44 4.43e-17 Hip circumference adjusted for BMI; CRC trans rs11250098 0.567 rs4326350 chr8:10763655 C/G cg06636001 chr8:8085503 FLJ10661 0.51 7.5 0.38 6e-13 Morning vs. evening chronotype; CRC cis rs1552244 0.832 rs3732968 chr3:10013273 A/G cg10729496 chr3:10149963 C3orf24 0.51 6.57 0.34 1.92e-10 Alzheimer's disease; CRC cis rs1448094 0.791 rs7300340 chr12:86329867 G/T cg25456477 chr12:86230367 RASSF9 0.34 5.74 0.3 2.14e-8 Major depressive disorder; CRC cis rs6502050 0.835 rs4789724 chr17:80150546 G/A cg02741985 chr17:80059408 CCDC57 0.44 7.33 0.37 1.76e-12 Life satisfaction; CRC cis rs2576037 0.583 rs501882 chr18:44411066 A/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.62 10.5 0.5 1.94e-22 Personality dimensions; CRC cis rs6714710 0.603 rs34502870 chr2:98405929 A/G cg26665480 chr2:98280029 ACTR1B 0.52 7.16 0.37 5.23e-12 Posterior cortical atrophy and Alzheimer's disease; CRC cis rs7615952 0.576 rs2276727 chr3:125826243 C/T cg15145296 chr3:125709740 NA -0.56 -6.63 -0.34 1.35e-10 Blood pressure (smoking interaction); CRC cis rs10504229 0.861 rs6990796 chr8:58183097 G/C cg02725872 chr8:58115012 NA -0.38 -6.43 -0.33 4.44e-10 Developmental language disorder (linguistic errors); CRC cis rs12188164 0.714 rs11741954 chr5:421455 G/T cg00976097 chr5:421733 AHRR -0.45 -6.02 -0.31 4.76e-9 Cystic fibrosis severity; CRC cis rs9811920 0.581 rs793468 chr3:99538346 T/C cg07805332 chr3:99536008 MIR548G;C3orf26 0.51 7.63 0.39 2.49e-13 Axial length; CRC cis rs9916302 0.904 rs1966916 chr17:37425238 T/G cg07936489 chr17:37558343 FBXL20 -0.83 -12.83 -0.58 7.83e-31 Glomerular filtration rate (creatinine); CRC cis rs2836974 0.568 rs8130795 chr21:40549983 T/A cg11644478 chr21:40555479 PSMG1 0.68 10.83 0.51 1.39e-23 Cognitive function; CRC cis rs9649213 0.593 rs7781916 chr7:97929738 A/G cg24562669 chr7:97807699 LMTK2 0.42 7.01 0.36 1.36e-11 Prostate cancer (SNP x SNP interaction); CRC cis rs9733 0.650 rs12406712 chr1:150545084 C/A cg18016565 chr1:150552671 MCL1 -0.47 -7.07 -0.36 9.07e-12 Tonsillectomy; CRC cis rs743757 0.878 rs12494849 chr3:50524558 C/G cg08207895 chr3:50388901 TUSC4;CYB561D2 0.43 6.02 0.31 4.78e-9 Diastolic blood pressure; CRC cis rs7216064 1.000 rs7210027 chr17:65977053 C/T cg12091567 chr17:66097778 LOC651250 0.64 8.27 0.41 3.3e-15 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CRC cis rs4243830 0.522 rs11122086 chr1:6601246 T/G cg05709478 chr1:6581295 PLEKHG5 -0.57 -6.68 -0.35 1.04e-10 Body mass index; CRC cis rs17253792 0.822 rs77761669 chr14:56034216 G/A cg01858014 chr14:56050164 KTN1 -0.84 -7.78 -0.39 9.76e-14 Putamen volume; CRC cis rs6570726 0.643 rs9403735 chr6:145936591 C/T cg23711669 chr6:146136114 FBXO30 0.76 12.89 0.58 4.8e-31 Lobe attachment (rater-scored or self-reported); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg14706950 chr10:93169801 HECTD2;LOC100188947 0.39 6.06 0.32 3.67e-9 Liver disease severity in Alagille syndrome; CRC cis rs9611565 0.625 rs9611606 chr22:41931074 A/G cg17554472 chr22:41940697 POLR3H -0.55 -5.93 -0.31 7.73e-9 Vitiligo; CRC cis rs7772486 0.875 rs2777484 chr6:146334162 A/G cg23711669 chr6:146136114 FBXO30 0.67 11.5 0.54 5.71e-26 Lobe attachment (rater-scored or self-reported); CRC cis rs9463078 0.547 rs764397 chr6:44710771 C/A cg25276700 chr6:44698697 NA 0.31 7.79 0.39 8.87e-14 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; CRC cis rs4363385 0.818 rs546666 chr1:153015385 A/G cg25856811 chr1:152973957 SPRR3 -0.27 -7.35 -0.38 1.6e-12 Inflammatory skin disease; CRC cis rs7927771 1.000 rs11039255 chr11:47495746 G/T cg05585544 chr11:47624801 NA -0.6 -10.83 -0.51 1.37e-23 Subjective well-being; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg16483426 chr12:110151678 C12orf34 0.42 5.99 0.31 5.39e-9 Anxiety disorder; CRC cis rs11252926 0.604 rs2050970 chr10:515870 C/T cg16386425 chr10:429943 DIP2C -0.38 -5.73 -0.3 2.3e-8 Psychosis in Alzheimer's disease; CRC trans rs1997103 1.000 rs4947504 chr7:55409428 T/C cg20935933 chr6:143382018 AIG1 0.5 6.42 0.33 4.64e-10 QRS interval (sulfonylurea treatment interaction); CRC cis rs10540 1.000 rs67912009 chr11:495057 G/T cg11503833 chr11:492997 NA 0.54 6.06 0.32 3.66e-9 Body mass index; CRC cis rs9443189 0.570 rs6931578 chr6:76272310 C/T cg01950844 chr6:76311363 SENP6 0.74 9.8 0.48 4.62e-20 Prostate cancer; CRC cis rs300703 0.719 rs400040 chr2:199422 G/T cg21211680 chr2:198530 NA 0.89 11.01 0.52 3.36e-24 Blood protein levels; CRC cis rs4713118 0.866 rs9468217 chr6:27726467 G/A cg12273811 chr6:28175739 NA 0.55 6.74 0.35 6.97e-11 Parkinson's disease; CRC cis rs11628318 0.614 rs72635192 chr14:103128646 C/T cg23461800 chr14:103021989 NA 0.68 7.74 0.39 1.23e-13 Platelet count; CRC cis rs7666738 0.830 rs11729753 chr4:98803267 T/A cg17366294 chr4:99064904 C4orf37 0.4 6.2 0.32 1.68e-9 Colonoscopy-negative controls vs population controls; CRC cis rs13191362 0.872 rs73020362 chr6:163005737 A/C cg21926612 chr6:163149169 PACRG;PARK2 0.8 11.15 0.52 1.08e-24 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs10905065 0.766 rs11598374 chr10:5826986 T/C cg11519256 chr10:5708881 ASB13 -0.44 -6.34 -0.33 7.8e-10 Menopause (age at onset); CRC cis rs11785400 0.793 rs4736367 chr8:143742477 G/A cg24634471 chr8:143751801 JRK 0.48 6.51 0.34 2.81e-10 Schizophrenia; CRC cis rs10751667 0.621 rs11246345 chr11:934924 T/C cg06064525 chr11:970664 AP2A2 -0.34 -6.75 -0.35 6.62e-11 Alzheimer's disease (late onset); CRC cis rs6089584 1.000 rs6089591 chr20:60570548 A/C cg18761221 chr20:60518478 NA 0.39 6.84 0.35 3.81e-11 Body mass index; CRC trans rs11098499 1.000 rs6837898 chr4:120179154 C/T cg25214090 chr10:38739885 LOC399744 0.51 7.86 0.4 5.61e-14 Corneal astigmatism; CRC cis rs1707322 0.928 rs925524 chr1:46496709 A/G cg06784218 chr1:46089804 CCDC17 -0.55 -9.66 -0.47 1.31e-19 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs172166 0.694 rs203877 chr6:28048624 T/C cg10876282 chr6:28092338 ZSCAN16 0.48 6.53 0.34 2.51e-10 Cardiac Troponin-T levels; CRC cis rs13108904 0.870 rs11727987 chr4:1261435 A/G cg02018176 chr4:1364513 KIAA1530 0.45 7.43 0.38 9.58e-13 Obesity-related traits; CRC cis rs6461049 0.765 rs4719432 chr7:2140330 A/G cg02951883 chr7:2050386 MAD1L1 -0.56 -9.05 -0.45 1.24e-17 Schizophrenia; CRC cis rs12701220 0.655 rs10215292 chr7:1135263 A/G cg26240231 chr7:1148101 C7orf50 -0.41 -6.04 -0.32 4.24e-9 Bronchopulmonary dysplasia; CRC cis rs2249694 1.000 rs1952467 chr10:135353499 T/G cg20169779 chr10:135381914 SYCE1 0.54 8.67 0.43 1.93e-16 Obesity-related traits; CRC cis rs28386778 0.687 rs59596917 chr17:61806264 T/A cg06873352 chr17:61820015 STRADA 0.79 14.79 0.63 2.66e-38 Prudent dietary pattern; CRC cis rs1862618 0.671 rs252897 chr5:56223000 G/A cg18230493 chr5:56204884 C5orf35 -0.58 -8.38 -0.42 1.61e-15 Initial pursuit acceleration; CRC cis rs13118159 0.509 rs10023473 chr4:1375285 C/T cg02018176 chr4:1364513 KIAA1530 0.67 11.58 0.54 3.01e-26 Longevity; CRC cis rs12220238 0.915 rs10824074 chr10:75876457 T/A cg19889307 chr10:75911429 ADK;AP3M1 0.61 6.18 0.32 1.87e-9 Soluble interleukin-2 receptor subunit alpha; CRC cis rs10751667 0.580 rs11246363 chr11:971667 T/C cg23136738 chr11:925521 AP2A2 -0.41 -7.0 -0.36 1.47e-11 Alzheimer's disease (late onset); CRC cis rs8141529 0.764 rs5762854 chr22:29246278 T/C cg02153584 chr22:29168773 CCDC117 0.53 7.84 0.4 6.46e-14 Lymphocyte counts; CRC cis rs910187 0.605 rs2281367 chr20:45808960 T/C cg27589058 chr20:45804311 EYA2 -0.4 -7.72 -0.39 1.39e-13 Migraine; CRC cis rs897984 0.762 rs2305880 chr16:30999462 T/C cg00531865 chr16:30841666 NA 0.48 6.9 0.36 2.62e-11 Dementia with Lewy bodies; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg11296937 chr11:64084966 PRDX5;TRMT112 -0.46 -6.63 -0.34 1.36e-10 Myopia (pathological); CRC cis rs6951245 1.000 rs79683221 chr7:1096139 A/G cg20603222 chr7:1096387 C7orf50;GPR146 -0.72 -8.67 -0.43 1.96e-16 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg08501533 chr10:12084975 UPF2 0.46 6.24 0.33 1.32e-9 Anxiety disorder; CRC cis rs11123170 0.640 rs2863240 chr2:113970116 C/T cg21482265 chr2:113992762 PAX8;LOC440839;LOC654433 -0.55 -7.28 -0.37 2.46e-12 Renal function-related traits (BUN); CRC cis rs9818758 0.607 rs71324929 chr3:49044713 C/T cg07636037 chr3:49044803 WDR6 -0.8 -6.18 -0.32 1.88e-9 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; CRC cis rs9311474 0.629 rs11709284 chr3:52559705 G/A cg18099408 chr3:52552593 STAB1 -0.64 -12.66 -0.57 3.39e-30 Electroencephalogram traits; CRC cis rs45544231 0.544 rs9931232 chr16:52572832 A/G cg09051775 chr16:52580266 TOX3 0.38 6.26 0.33 1.22e-9 Restless legs syndrome; CRC trans rs11148252 0.846 rs9379 chr13:53050479 G/A cg18335740 chr13:41363409 SLC25A15 0.54 8.42 0.42 1.14e-15 Lewy body disease; CRC cis rs826838 1.000 rs826888 chr12:39104719 C/G cg26384229 chr12:38710491 ALG10B -0.62 -9.5 -0.46 4.4e-19 Heart rate; CRC cis rs11785693 0.862 rs73183633 chr8:4994543 G/A cg26367366 chr8:4980734 NA 0.8 9.92 0.48 1.77e-20 Neuroticism (multi-trait analysis);Neuroticism; CRC cis rs6496044 0.568 rs11855789 chr15:86066403 G/A cg17133734 chr15:86042851 AKAP13 0.4 6.51 0.34 2.8e-10 Interstitial lung disease; CRC cis rs12477438 0.520 rs4402818 chr2:99717608 A/G cg26064155 chr2:99771622 LIPT1;TSGA10 0.83 14.73 0.63 4.73e-38 Chronic sinus infection; CRC cis rs1577917 0.916 rs4706252 chr6:86555180 G/A cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.51 -6.59 -0.34 1.76e-10 Response to antipsychotic treatment; CRC cis rs9911578 0.935 rs7218105 chr17:57041119 A/G cg12560992 chr17:57184187 TRIM37 0.93 17.28 0.69 4.48e-48 Intelligence (multi-trait analysis); CRC cis rs3790844 0.876 rs3790845 chr1:200006861 C/T cg13229857 chr1:200006247 NR5A2 0.54 7.62 0.39 2.68e-13 Pancreatic cancer; CRC cis rs9611565 0.592 rs12484254 chr22:41962003 T/A cg03806693 chr22:41940476 POLR3H -0.89 -11.17 -0.52 8.84e-25 Vitiligo; CRC cis rs3812762 0.618 rs11042072 chr11:8822032 A/G cg00186954 chr11:8933980 ST5;C11orf17 -0.49 -7.25 -0.37 2.91e-12 Hypospadias; CRC cis rs6952808 1.000 rs10233560 chr7:1885415 T/C cg20295408 chr7:1910781 MAD1L1 -0.41 -5.97 -0.31 6.27e-9 Bipolar disorder and schizophrenia; CRC cis rs6748734 1.000 rs11898716 chr2:241828311 A/G cg07537917 chr2:241836409 C2orf54 -0.22 -6.3 -0.33 9.33e-10 Urinary metabolites; CRC cis rs7487075 0.578 rs10880967 chr12:46812023 T/C cg22049899 chr12:47219821 SLC38A4 0.31 5.67 0.3 3.17e-8 Itch intensity from mosquito bite; CRC cis rs10504229 0.683 rs7827881 chr8:58132137 C/T cg04204079 chr8:58130323 NA -0.45 -5.74 -0.3 2.21e-8 Developmental language disorder (linguistic errors); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg13374225 chr1:10093824 UBE4B 0.42 6.02 0.31 4.65e-9 Response to antipsychotic treatment; CRC cis rs9467711 0.651 rs17587597 chr6:25986451 G/A cg08501292 chr6:25962987 TRIM38 1.08 8.98 0.44 2.12e-17 Autism spectrum disorder or schizophrenia; CRC cis rs2153535 0.541 rs9392222 chr6:8467649 G/A cg07606381 chr6:8435919 SLC35B3 0.67 10.7 0.51 4.01e-23 Motion sickness; CRC cis rs9611565 0.694 rs202641 chr22:41833116 C/T cg06481639 chr22:41940642 POLR3H 0.47 5.78 0.3 1.74e-8 Vitiligo; CRC cis rs68170813 0.559 rs7793594 chr7:106891829 C/T cg02696742 chr7:106810147 HBP1 -0.6 -6.65 -0.34 1.25e-10 Coronary artery disease; CRC cis rs6499255 0.951 rs8052086 chr16:69692468 A/C cg04110750 chr16:69646130 NFAT5 -0.57 -7.82 -0.4 7.23e-14 IgE levels; CRC cis rs13191362 0.872 rs13215538 chr6:163037975 T/C cg14584255 chr6:163149320 PACRG;PARK2 0.4 5.78 0.3 1.77e-8 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs7584330 0.554 rs74832280 chr2:238426625 G/A cg14458575 chr2:238380390 NA 0.46 6.51 0.34 2.8e-10 Prostate cancer; CRC cis rs9611565 0.568 rs5751159 chr22:42175365 G/A cg03806693 chr22:41940476 POLR3H 0.68 9.46 0.46 6.05e-19 Vitiligo; CRC cis rs977987 0.806 rs2903033 chr16:75389606 T/A cg03315344 chr16:75512273 CHST6 0.52 8.74 0.43 1.22e-16 Dupuytren's disease; CRC cis rs1862618 0.613 rs252889 chr5:56227069 C/A cg18230493 chr5:56204884 C5orf35 -0.6 -8.76 -0.43 1.03e-16 Initial pursuit acceleration; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg09423085 chr2:68478351 PPP3R1 0.48 6.15 0.32 2.23e-9 Thyroid stimulating hormone; CRC cis rs2075371 1.000 rs2544211 chr7:133973230 A/G cg11752832 chr7:134001865 SLC35B4 0.48 7.29 0.37 2.34e-12 Mean platelet volume; CRC cis rs597539 0.654 rs655816 chr11:68626405 A/G cg06112835 chr11:68658793 MRPL21 0.45 7.23 0.37 3.31e-12 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs185694 0.947 rs202079 chr13:30879154 C/T cg04551440 chr13:30881194 KATNAL1 -0.66 -6.52 -0.34 2.59e-10 Antineutrophil cytoplasmic antibody-associated vasculitis; CRC cis rs6460942 1.000 rs75564554 chr7:12319362 A/C cg06484146 chr7:12443880 VWDE -0.76 -7.53 -0.38 4.85e-13 Coronary artery disease; CRC cis rs4285028 0.699 rs7637495 chr3:121573850 C/T cg20356878 chr3:121714668 ILDR1 -0.47 -6.74 -0.35 7.17e-11 Multiple sclerosis; CRC cis rs13082711 0.911 rs36101969 chr3:27438181 G/A cg02860705 chr3:27208620 NA 0.62 8.88 0.44 4.31e-17 Systolic blood pressure;Diastolic blood pressure;Blood pressure; CRC cis rs2479724 1.000 rs2254479 chr6:41831143 G/A cg17623882 chr6:41773611 USP49 -0.53 -8.81 -0.44 7.13e-17 Menarche (age at onset); CRC cis rs990171 0.955 rs10197881 chr2:103091715 A/G cg03938978 chr2:103052716 IL18RAP 0.46 5.85 0.31 1.19e-8 Lymphocyte counts; CRC trans rs11343 0.675 rs7359333 chr16:19262344 A/T cg15331096 chr17:29861932 RAB11FIP4 -0.42 -6.16 -0.32 2.16e-9 Parkinson's disease; CRC cis rs7208859 0.623 rs9914499 chr17:29107588 G/A cg13385521 chr17:29058706 SUZ12P 0.73 8.33 0.42 2.14e-15 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs2404602 0.735 rs11638767 chr15:76655938 T/C cg23625390 chr15:77176239 SCAPER -0.84 -13.6 -0.6 1e-33 Blood metabolite levels; CRC cis rs514406 0.755 rs10888754 chr1:53228751 C/G cg27535305 chr1:53392650 SCP2 0.38 7.2 0.37 4.06e-12 Monocyte count; CRC cis rs35146811 0.735 rs2528900 chr7:99805319 A/G cg13334819 chr7:99746414 C7orf59 0.51 6.72 0.35 7.79e-11 Coronary artery disease; CRC cis rs736408 0.509 rs13083798 chr3:52649748 A/G cg10802521 chr3:52805072 NEK4 -0.47 -7.42 -0.38 1.02e-12 Bipolar disorder; CRC cis rs6840360 0.967 rs4696105 chr4:152606702 T/G cg09659197 chr4:152720779 NA 0.51 11.12 0.52 1.29e-24 Intelligence (multi-trait analysis); CRC cis rs7666738 0.791 rs1115615 chr4:99006614 G/A cg05340658 chr4:99064831 C4orf37 0.61 9.49 0.46 4.96e-19 Colonoscopy-negative controls vs population controls; CRC cis rs2398668 0.622 rs62442516 chr7:2306984 C/T cg08027265 chr7:2291960 NA 0.44 7.93 0.4 3.35e-14 Bipolar disorder and schizophrenia; CRC trans rs2303319 0.504 rs62188988 chr2:162531068 T/C cg06218622 chr17:8079772 TMEM107 -0.68 -5.99 -0.31 5.48e-9 Cognitive function; CRC cis rs1322512 0.958 rs12195158 chr6:153006544 T/C cg03415253 chr6:152958462 SYNE1 0.4 6.03 0.32 4.39e-9 Tonometry; CRC cis rs9914988 0.887 rs12948575 chr17:27130520 G/A cg07195577 chr17:27052828 TLCD1 0.42 6.02 0.32 4.64e-9 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs9611519 0.929 rs71327107 chr22:41418229 T/G cg03806693 chr22:41940476 POLR3H -0.52 -6.01 -0.31 4.91e-9 Neuroticism; CRC cis rs1740073 0.624 rs9472179 chr6:43938931 C/T cg14777908 chr6:43939685 NA -0.53 -8.94 -0.44 2.87e-17 Vascular endothelial growth factor levels; CRC cis rs4965006 0.915 rs4965004 chr12:132424700 A/G cg00588090 chr12:132412438 PUS1 0.53 6.58 0.34 1.81e-10 Posterior cortical atrophy and Alzheimer's disease; CRC cis rs853679 0.882 rs4713140 chr6:28097193 C/T cg03623178 chr6:28175578 NA 0.81 6.68 0.35 1.04e-10 Depression; CRC cis rs9322193 0.887 rs3734295 chr6:149915053 C/T cg13206674 chr6:150067644 NUP43 0.66 9.68 0.47 1.12e-19 Lung cancer; CRC cis rs10927875 1.000 rs12138117 chr1:16305279 T/C cg22431228 chr1:16359049 CLCNKA 0.34 5.95 0.31 6.72e-9 Dilated cardiomyopathy; CRC cis rs2228479 0.850 rs62054609 chr16:89816569 C/A cg19635926 chr16:89946313 TCF25 0.66 5.97 0.31 6.1e-9 Skin colour saturation; CRC cis rs9910055 0.762 rs7213436 chr17:42252163 A/G cg09913183 chr17:42254507 C17orf65;ASB16 -0.61 -8.89 -0.44 4.14e-17 Total body bone mineral density; CRC cis rs12188164 1.000 rs56104584 chr5:437542 T/C cg26850624 chr5:429559 AHRR -0.81 -13.83 -0.61 1.3e-34 Cystic fibrosis severity; CRC cis rs9311474 0.967 rs11717383 chr3:52287468 G/T cg18099408 chr3:52552593 STAB1 -0.47 -8.0 -0.4 2.21e-14 Electroencephalogram traits; CRC cis rs7809950 0.954 rs2520245 chr7:107137428 G/C cg23024343 chr7:107201750 COG5 -0.62 -8.72 -0.43 1.41e-16 Coronary artery disease; CRC cis rs1030877 0.515 rs2679895 chr2:105906480 C/G cg02079111 chr2:105885981 TGFBRAP1 0.48 6.73 0.35 7.74e-11 Obesity-related traits; CRC cis rs8062405 1.000 rs28403629 chr16:28854769 A/G cg16576597 chr16:28551801 NUPR1 0.48 6.83 0.35 4.24e-11 Cognitive ability (multi-trait analysis);Cognitive ability; CRC cis rs75804782 0.581 rs13415491 chr2:239319901 C/T cg18131467 chr2:239335373 ASB1 -0.7 -6.06 -0.32 3.71e-9 Morning vs. evening chronotype;Chronotype; CRC cis rs6951245 0.935 rs61753396 chr7:1105372 A/G cg20603222 chr7:1096387 C7orf50;GPR146 -0.73 -8.68 -0.43 1.92e-16 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs11212617 1.000 rs7943165 chr11:108274890 T/C cg01991180 chr11:108092276 ATM;NPAT 0.43 6.39 0.33 5.72e-10 Response to metformin in type 2 diabetes (glycemic); CRC cis rs10540 1.000 rs61876332 chr11:487101 C/T cg03934478 chr11:495069 RNH1 0.67 7.22 0.37 3.66e-12 Body mass index; CRC cis rs875971 1.000 rs2036264 chr7:65799904 G/A cg11764359 chr7:65958608 NA -0.63 -10.06 -0.49 6.04e-21 Aortic root size; CRC cis rs6831352 0.918 rs4699713 chr4:100060513 C/T cg13256891 chr4:100009986 ADH5 -0.66 -8.98 -0.44 2.17e-17 Alcohol dependence; CRC cis rs9660180 0.935 rs9786942 chr1:1759213 A/G cg03396347 chr1:1875803 NA -0.6 -9.11 -0.45 8.23e-18 Body mass index; CRC cis rs12681288 0.862 rs2701898 chr8:1020812 C/T cg15309053 chr8:964076 NA 0.36 6.03 0.32 4.38e-9 Schizophrenia; CRC cis rs9304742 0.924 rs8111196 chr19:53457223 A/G cg09915433 chr19:53449742 NA -0.6 -8.96 -0.44 2.5e-17 Psoriasis; CRC cis rs67311347 0.524 rs11129869 chr3:40259738 G/A cg09455208 chr3:40491958 NA 0.32 6.68 0.35 9.99e-11 Renal cell carcinoma; CRC cis rs9462027 0.606 rs7341253 chr6:34726838 G/A cg07306190 chr6:34760872 UHRF1BP1 -0.35 -6.25 -0.33 1.28e-9 Systemic lupus erythematosus; CRC cis rs9733 0.527 rs11204694 chr1:150653391 G/A cg10589385 chr1:150898437 SETDB1 0.31 6.49 0.34 3.2e-10 Tonsillectomy; CRC cis rs9467711 0.651 rs72834677 chr6:26106604 C/A cg16898833 chr6:26189333 HIST1H4D 0.69 6.06 0.32 3.64e-9 Autism spectrum disorder or schizophrenia; CRC cis rs6951245 1.000 rs74366004 chr7:1088630 A/C cg18402987 chr7:1209562 NA 0.64 6.67 0.35 1.05e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs919433 0.680 rs2565163 chr2:198354414 T/C cg10820045 chr2:198174542 NA 0.39 6.41 0.33 4.9e-10 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC cis rs10847980 0.590 rs12299742 chr12:123323357 T/G cg25930673 chr12:123319894 HIP1R 0.69 5.85 0.31 1.17e-8 Adiponectin levels; CRC cis rs798554 0.796 rs2533884 chr7:2836848 T/G cg19717773 chr7:2847554 GNA12 -0.48 -6.73 -0.35 7.41e-11 Height; CRC cis rs7666738 0.791 rs2081622 chr4:98927369 T/C cg17366294 chr4:99064904 C4orf37 0.43 7.32 0.37 1.95e-12 Colonoscopy-negative controls vs population controls; CRC cis rs889398 0.641 rs9936589 chr16:69884817 C/T cg00738113 chr16:70207722 CLEC18C -0.37 -6.46 -0.34 3.69e-10 Body mass index; CRC cis rs7843479 0.965 rs4636204 chr8:21823206 T/G cg17168535 chr8:21777572 XPO7 0.54 8.73 0.43 1.35e-16 Mean corpuscular volume; CRC cis rs3820068 0.603 rs56032936 chr1:15970953 T/C cg24675056 chr1:15929824 NA 0.53 7.22 0.37 3.68e-12 Systolic blood pressure; CRC cis rs72615157 0.634 rs2272343 chr7:99778285 A/C cg00814883 chr7:100076585 TSC22D4 -0.51 -6.11 -0.32 2.82e-9 Lung function (FEV1/FVC); CRC cis rs6543140 0.964 rs11886793 chr2:103072220 T/G cg03938978 chr2:103052716 IL18RAP 0.41 6.54 0.34 2.37e-10 Blood protein levels; CRC cis rs7618915 0.508 rs12498066 chr3:52627660 G/A cg11645453 chr3:52864694 ITIH4 0.35 6.13 0.32 2.58e-9 Bipolar disorder; CRC cis rs17065868 1.000 rs9533919 chr13:45156951 C/T cg10246903 chr13:45222710 NA 0.53 5.7 0.3 2.64e-8 Antineutrophil cytoplasmic antibody-associated vasculitis; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg07671174 chr3:58224051 ABHD6 0.45 6.25 0.33 1.27e-9 Response to antipsychotic treatment; CRC cis rs10982256 0.774 rs10759711 chr9:117253308 T/G cg13636371 chr9:117264095 DFNB31 0.35 6.69 0.35 9.85e-11 Bipolar disorder; CRC cis rs12497850 0.866 rs6791234 chr3:48996137 A/G cg07636037 chr3:49044803 WDR6 1.02 18.22 0.71 8.99e-52 Parkinson's disease; CRC cis rs4713118 0.699 rs573179 chr6:27849676 C/A cg12273811 chr6:28175739 NA 0.58 7.55 0.38 4.33e-13 Parkinson's disease; CRC cis rs7493 1.000 rs3779492 chr7:95044183 C/T cg21856205 chr7:94953877 PON1 -0.48 -6.28 -0.33 1.1e-9 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs11190604 1.000 rs7073586 chr10:102307671 A/G cg16342193 chr10:102329863 NA -0.34 -5.93 -0.31 7.59e-9 Palmitoleic acid (16:1n-7) levels; CRC cis rs4731207 0.596 rs34555990 chr7:124587844 T/C cg23710748 chr7:124431027 NA -0.38 -6.08 -0.32 3.35e-9 Cutaneous malignant melanoma; CRC cis rs281302 0.621 rs421853 chr15:47744331 C/T cg13159054 chr15:47721715 NA -0.46 -6.84 -0.35 3.95e-11 Educational attainment (years of education);Cognitive ability (multi-trait analysis); CRC cis rs9903692 0.908 rs9807087 chr17:46204138 A/G cg21215337 chr17:46176117 CBX1 -0.42 -7.83 -0.4 6.74e-14 Pulse pressure; CRC cis rs10791097 0.694 rs4436551 chr11:130755739 A/G cg12179176 chr11:130786555 SNX19 -0.75 -12.39 -0.56 3.44e-29 Autism spectrum disorder or schizophrenia;Schizophrenia; CRC cis rs12912251 0.591 rs3104150 chr15:39003585 T/C cg10631289 chr15:39006617 NA -0.49 -5.64 -0.3 3.75e-8 Bipolar disorder;Bipolar disorder or major depressive disorder (combined); CRC cis rs11105298 0.891 rs10858864 chr12:89846230 C/T cg08166232 chr12:89918718 WDR51B;GALNT4 -0.61 -7.74 -0.39 1.27e-13 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; CRC trans rs8002861 0.515 rs9525846 chr13:44390857 A/G cg17145862 chr1:211918768 LPGAT1 -0.6 -10.98 -0.52 4.17e-24 Leprosy; CRC cis rs10411161 0.702 rs10423838 chr19:52387283 C/T cg11269599 chr19:52391304 ZNF577 0.45 5.73 0.3 2.26e-8 Breast cancer; CRC cis rs4711350 0.953 rs942496 chr6:33788055 A/G cg07979401 chr6:33739406 LEMD2 -0.45 -5.61 -0.3 4.36e-8 Schizophrenia; CRC cis rs116095464 0.558 rs10055405 chr5:265666 C/T cg22857025 chr5:266934 NA -1.25 -16.72 -0.68 7.33e-46 Breast cancer; CRC cis rs6977940 0.558 rs11768054 chr7:2888015 T/G cg19731401 chr7:2775893 GNA12 0.6 5.78 0.3 1.78e-8 White matter integrity; CRC cis rs243505 0.632 rs887571 chr7:148505253 G/A cg09806900 chr7:148480153 CUL1 0.49 7.1 0.36 7.9e-12 Inflammatory bowel disease;Crohn's disease; CRC cis rs1799949 0.894 rs36062488 chr17:41337472 C/T cg25072359 chr17:41440525 NA -0.52 -8.3 -0.42 2.79e-15 Menopause (age at onset); CRC cis rs1046896 1.000 rs9909940 chr17:80689036 C/T cg19046167 chr17:80928561 B3GNTL1 0.42 6.51 0.34 2.87e-10 Glycated hemoglobin levels; CRC trans rs9341835 0.584 rs2622286 chr6:64150067 A/T cg13657004 chr13:50234944 EBPL -0.37 -6.38 -0.33 6.03e-10 Schizophrenia; CRC cis rs7811142 1.000 rs1073 chr7:100031612 G/A cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.65 8.3 0.42 2.77e-15 Platelet count; CRC cis rs2976388 1.000 rs2920292 chr8:143765699 A/G cg04969067 chr8:143858791 LYNX1 -0.36 -6.07 -0.32 3.58e-9 Urinary tract infection frequency; CRC cis rs3820068 0.532 rs78917815 chr1:15920821 A/G cg24675056 chr1:15929824 NA 0.47 6.21 0.32 1.56e-9 Systolic blood pressure; CRC cis rs13256369 0.802 rs11249883 chr8:8561537 G/A cg18904891 chr8:8559673 CLDN23 0.52 6.91 0.36 2.51e-11 Obesity-related traits; CRC cis rs67311347 1.000 rs17078511 chr3:40396254 A/G cg24209194 chr3:40518798 ZNF619 0.38 5.73 0.3 2.32e-8 Renal cell carcinoma; CRC cis rs2179367 0.632 rs2143075 chr6:149746643 A/G cg11245181 chr6:149772854 ZC3H12D -0.4 -5.62 -0.3 4.16e-8 Dupuytren's disease; CRC cis rs2882667 0.898 rs12719519 chr5:138375687 G/A cg09476006 chr5:138032270 NA 0.45 7.46 0.38 7.7e-13 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs920590 0.510 rs4922101 chr8:19648895 A/G cg03894339 chr8:19674705 INTS10 0.57 7.38 0.38 1.28e-12 Acute lymphoblastic leukemia (childhood); CRC cis rs9311676 0.656 rs56028017 chr3:58372508 C/T cg06643156 chr3:58380774 PXK 0.42 6.37 0.33 6.33e-10 Systemic lupus erythematosus; CRC cis rs4665809 0.627 rs7562192 chr2:26469457 C/G cg22920501 chr2:26401640 FAM59B 0.85 12.68 0.57 2.93e-30 Gut microbiome composition (summer); CRC cis rs4363385 0.658 rs426147 chr1:153045011 G/C cg25856811 chr1:152973957 SPRR3 -0.24 -6.58 -0.34 1.86e-10 Inflammatory skin disease; CRC cis rs7618915 0.547 rs12486847 chr3:52691112 T/C cg10802521 chr3:52805072 NEK4 -0.58 -8.85 -0.44 5.34e-17 Bipolar disorder; CRC cis rs72781680 0.752 rs72796138 chr2:23926233 C/T cg08917208 chr2:24149416 ATAD2B 0.96 8.95 0.44 2.61e-17 Lymphocyte counts; CRC cis rs2276314 1.000 rs2276314 chr18:33557466 C/T cg19628046 chr18:33552617 C18orf21 -0.53 -7.58 -0.39 3.44e-13 Endometriosis;Drug-induced torsades de pointes; CRC cis rs826838 0.967 rs6580726 chr12:39108623 T/C cg26384229 chr12:38710491 ALG10B -0.62 -9.5 -0.46 4.4e-19 Heart rate; CRC cis rs17345786 1.000 rs3804775 chr3:101306507 C/T cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.55 6.74 0.35 7.06e-11 Colonoscopy-negative controls vs population controls; CRC trans rs1005277 0.577 rs4934906 chr10:38015028 C/T cg27523141 chr10:43048294 ZNF37B 0.42 5.99 0.31 5.54e-9 Extrinsic epigenetic age acceleration; CRC cis rs56114371 0.777 rs200481 chr6:27773832 A/T cg19041857 chr6:27730383 NA -0.67 -6.61 -0.34 1.51e-10 Breast cancer; CRC cis rs1476670 0.710 rs751442 chr1:44509551 A/C cg09470012 chr1:44509516 NA 0.42 6.94 0.36 2.1e-11 Eotaxin levels; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg11317343 chr5:177580912 NHP2 0.48 6.75 0.35 6.53e-11 Response to antipsychotic treatment; CRC cis rs3126085 0.935 rs7531094 chr1:152176850 A/G cg09127314 chr1:152161683 NA 0.54 6.92 0.36 2.32e-11 Atopic dermatitis; CRC cis rs427941 0.632 rs201498 chr7:101756262 G/A cg06246474 chr7:101738831 CUX1 0.44 6.73 0.35 7.61e-11 Plasma omega-3 polyunsaturated fatty acid level (eicosapentaenoic acid); CRC cis rs7119 0.931 rs7176875 chr15:77832675 A/G cg22256960 chr15:77711686 NA 0.41 5.63 0.3 3.88e-8 Type 2 diabetes; CRC cis rs6831352 0.918 rs2851248 chr4:100045974 A/G cg12011299 chr4:100065546 ADH4 0.48 9.05 0.45 1.24e-17 Alcohol dependence; CRC cis rs7772486 0.790 rs9403749 chr6:146162239 A/G cg23711669 chr6:146136114 FBXO30 0.77 13.51 0.6 2.17e-33 Lobe attachment (rater-scored or self-reported); CRC cis rs9467711 0.591 rs60512607 chr6:26054171 T/A cg08501292 chr6:25962987 TRIM38 0.72 7.22 0.37 3.66e-12 Autism spectrum disorder or schizophrenia; CRC cis rs9611565 0.512 rs139572 chr22:42214532 C/T cg06634786 chr22:41940651 POLR3H -0.67 -6.85 -0.35 3.69e-11 Vitiligo; CRC cis rs9916302 0.904 rs35335692 chr17:37710006 A/G cg00129232 chr17:37814104 STARD3 -0.56 -8.33 -0.42 2.16e-15 Glomerular filtration rate (creatinine); CRC cis rs6089584 0.850 rs881993 chr20:60623862 A/G cg23262073 chr20:60523788 NA -0.49 -7.55 -0.38 4.2e-13 Body mass index; CRC cis rs9427116 0.702 rs884618 chr1:154601157 A/G cg17218026 chr1:154582156 ADAR 0.63 10.27 0.49 1.21e-21 Blood protein levels; CRC cis rs28735056 1.000 rs28735056 chr18:77622879 A/G cg20368463 chr18:77673604 PQLC1 -0.51 -7.92 -0.4 3.6e-14 Schizophrenia; CRC cis rs2952156 0.920 rs2517955 chr17:37843681 C/T cg11212589 chr17:38028394 ZPBP2 0.35 6.17 0.32 2e-9 Asthma; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg27367768 chr5:171615456 STK10 -0.38 -5.98 -0.31 5.74e-9 Myopia (pathological); CRC cis rs10504229 0.683 rs73603877 chr8:58108428 C/T cg02290350 chr8:58132656 NA -0.59 -8.03 -0.4 1.7e-14 Developmental language disorder (linguistic errors); CRC cis rs6809651 0.524 rs12638263 chr3:185795855 A/C cg00760338 chr3:185826511 ETV5 -0.66 -8.18 -0.41 6.34e-15 Body mass index in physically active individuals;Glomerular filtration rate (creatinine);Body mass index (joint analysis main effects and physical activity interaction);Body mass index;Body mass index in physically inactive individuals; CRC cis rs3736485 0.934 rs11634999 chr15:51871461 C/T cg08986416 chr15:51914746 DMXL2 -0.46 -6.63 -0.34 1.41e-10 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs67311347 0.544 rs2278930 chr3:40351092 C/T cg09455208 chr3:40491958 NA 0.31 6.19 0.32 1.8e-9 Renal cell carcinoma; CRC cis rs7523050 0.643 rs35860016 chr1:109404639 C/T cg08274380 chr1:109419600 GPSM2 0.86 6.9 0.36 2.74e-11 Fat distribution (HIV); CRC cis rs651907 0.513 rs34963630 chr3:101504817 C/T cg12386194 chr3:101231763 SENP7 0.52 7.42 0.38 1.01e-12 Colorectal cancer; CRC cis rs4481887 1.000 rs10788775 chr1:248471945 C/G cg00666640 chr1:248458726 OR2T12 0.52 9.09 0.45 9.69e-18 Common traits (Other); CRC cis rs6951245 0.572 rs79396168 chr7:1048928 C/T cg26224354 chr7:1096374 C7orf50;GPR146 -0.93 -7.91 -0.4 3.83e-14 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs10878977 0.542 rs58786840 chr12:69799163 C/T cg20891283 chr12:69753455 YEATS4 -0.61 -6.13 -0.32 2.52e-9 Colorectal cancer; CRC cis rs9399135 0.967 rs2327578 chr6:135329969 C/T cg24558204 chr6:135376177 HBS1L 0.51 8.13 0.41 8.55e-15 Red blood cell count; CRC cis rs780096 0.526 rs1260341 chr2:27663215 T/A cg24768116 chr2:27665128 KRTCAP3 -0.36 -8.22 -0.41 4.71e-15 Total body bone mineral density; CRC cis rs2204008 0.720 rs11180923 chr12:38255172 A/T cg26384229 chr12:38710491 ALG10B 0.67 9.01 0.44 1.77e-17 Bladder cancer; CRC cis rs4713118 0.869 rs7773070 chr6:27728827 T/C cg21251018 chr6:28226885 NKAPL 0.39 5.82 0.31 1.42e-8 Parkinson's disease; CRC cis rs4936891 0.577 rs4936885 chr11:123905876 C/A cg22125253 chr11:123886957 OR10G4 -0.33 -5.79 -0.3 1.61e-8 Male fertility; CRC cis rs10751667 0.666 rs12295141 chr11:947065 G/A cg06064525 chr11:970664 AP2A2 -0.31 -6.28 -0.33 1.09e-9 Alzheimer's disease (late onset); CRC cis rs13191362 0.935 rs66962088 chr6:162963891 C/T cg06582575 chr6:163149167 PACRG;PARK2 0.81 10.14 0.49 3.29e-21 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs2836974 0.897 rs2836925 chr21:40532353 T/C cg17971929 chr21:40555470 PSMG1 0.81 11.89 0.55 2.36e-27 Cognitive function; CRC cis rs28386778 0.897 rs4968597 chr17:61805747 G/A cg23090583 chr17:61904693 PSMC5;FTSJ3 1.03 19.61 0.73 2.85e-57 Prudent dietary pattern; CRC cis rs10504229 0.815 rs55855654 chr8:58164299 T/G cg24829409 chr8:58192753 C8orf71 -0.62 -8.25 -0.41 3.81e-15 Developmental language disorder (linguistic errors); CRC cis rs7119 0.689 rs12907630 chr15:77812906 G/T cg10437265 chr15:77819839 NA 0.67 12.42 0.56 2.72e-29 Type 2 diabetes; CRC cis rs2996428 0.667 rs11578070 chr1:3769871 G/C cg17848003 chr1:3704513 LRRC47 0.41 5.95 0.31 6.88e-9 Red cell distribution width; CRC cis rs6938 0.575 rs12902515 chr15:75160998 G/C cg18612461 chr15:75251733 NA 0.37 5.85 0.31 1.21e-8 Breast cancer; CRC cis rs10504229 1.000 rs111915672 chr8:58191665 T/C cg02725872 chr8:58115012 NA -0.37 -6.06 -0.32 3.69e-9 Developmental language disorder (linguistic errors); CRC cis rs9910055 0.659 rs7214540 chr17:42256604 A/G cg13607699 chr17:42295918 UBTF 0.41 5.69 0.3 2.85e-8 Total body bone mineral density; CRC trans rs61931739 0.500 rs7971957 chr12:34477558 C/T cg13010199 chr12:38710504 ALG10B 0.44 6.3 0.33 9.74e-10 Morning vs. evening chronotype; CRC cis rs887829 0.569 rs4124874 chr2:234665659 T/G cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.45 -7.02 -0.36 1.31e-11 Metabolic traits;Bilirubin levels;Cholelithiasis-related traits in sickle cell anemia;Metabolite levels;Total bilirubin levels in HIV-1 infection;Serum metabolite levels;Blood metabolite levels; CRC cis rs875971 0.642 rs35526611 chr7:66094008 C/T cg00343986 chr7:65444356 GUSB -0.51 -7.61 -0.39 2.83e-13 Aortic root size; CRC cis rs4730250 0.711 rs117026964 chr7:107063656 C/A cg02696742 chr7:106810147 HBP1 -0.62 -6.19 -0.32 1.79e-9 Osteoarthritis; CRC cis rs7474896 0.537 rs2505255 chr10:38359642 C/A cg25427524 chr10:38739819 LOC399744 -0.63 -7.76 -0.39 1.1e-13 Obesity (extreme); CRC cis rs4664293 0.625 rs3821300 chr2:160567230 A/G cg08347373 chr2:160653686 CD302 0.4 6.8 0.35 4.91e-11 Monocyte percentage of white cells; CRC trans rs2727020 0.658 rs7111215 chr11:49430552 T/C cg21153622 chr11:89784906 NA -0.37 -6.03 -0.32 4.36e-9 Coronary artery disease; CRC cis rs7385804 0.761 rs507392 chr7:100319936 G/A cg20848291 chr7:100343083 ZAN 0.5 7.58 0.39 3.46e-13 Iron status biomarkers;Mean corpuscular hemoglobin;Hematocrit;Iron status biomarkers (transferrin saturation);Red blood cell count;Iron status biomarkers (iron levels);Mean corpuscular volume;Hematological parameters; CRC cis rs9911578 1.000 rs12947785 chr17:57045160 A/C cg12560992 chr17:57184187 TRIM37 0.93 17.28 0.69 4.48e-48 Intelligence (multi-trait analysis); CRC cis rs4321325 0.733 rs79208542 chr2:127935686 G/C cg11380483 chr2:127933992 NA 0.63 7.7 0.39 1.64e-13 Protein C levels; CRC cis rs1448094 0.556 rs61930626 chr12:86167445 A/G cg00310523 chr12:86230176 RASSF9 0.4 6.52 0.34 2.6200000000000003e-10 Major depressive disorder; CRC cis rs5753037 0.547 rs140134 chr22:30163332 G/A cg01021169 chr22:30184971 ASCC2 -0.38 -5.9 -0.31 9.07e-9 Type 1 diabetes; CRC cis rs362272 0.502 rs2798298 chr4:3036602 G/A cg22930642 chr4:2936657 C4orf10;MFSD10 -0.4 -5.74 -0.3 2.13e-8 Serum sulfate level; CRC cis rs7647973 0.667 rs4241405 chr3:49642027 C/T cg13072238 chr3:49761600 GMPPB -0.52 -5.75 -0.3 2.05e-8 Menarche (age at onset); CRC cis rs4713118 0.629 rs203890 chr6:28022248 T/C cg03623178 chr6:28175578 NA 0.92 13.12 0.59 6.4e-32 Parkinson's disease; CRC cis rs10911251 0.546 rs1547715 chr1:183113952 A/G ch.1.3577855R chr1:183094577 LAMC1 0.83 14.65 0.63 9.3e-38 Colorectal cancer; CRC cis rs11758351 0.660 rs16891455 chr6:26230485 G/A cg08260959 chr6:26240920 HIST1H4F -0.35 -5.66 -0.3 3.34e-8 Gout;Renal underexcretion gout; CRC cis rs2276314 0.857 rs62101376 chr18:33582955 T/C cg05985134 chr18:33552581 C18orf21 0.44 5.9 0.31 9.21e-9 Endometriosis;Drug-induced torsades de pointes; CRC cis rs1355223 0.506 rs1828299 chr11:34870418 T/C cg11058730 chr11:34937778 PDHX;APIP -0.43 -6.08 -0.32 3.26e-9 Systemic lupus erythematosus and Systemic sclerosis; CRC cis rs7677751 0.848 rs7673625 chr4:55088586 C/T cg00691999 chr4:55094011 PDGFRA 0.44 6.27 0.33 1.15e-9 Corneal astigmatism; CRC cis rs10256972 0.552 rs6978842 chr7:1204599 A/C cg16145915 chr7:1198662 ZFAND2A -0.6 -13.71 -0.6 3.82e-34 Longevity;Endometriosis; CRC cis rs459482 1.000 rs464783 chr21:42796480 A/G cg14166395 chr21:42792516 MX1 -0.51 -7.05 -0.36 1.06e-11 IgG glycosylation; CRC cis rs7725052 0.609 rs4957297 chr5:40455074 A/G cg09067459 chr5:40385259 NA 0.38 6.31 0.33 9.04e-10 Pediatric autoimmune diseases; CRC cis rs1865760 0.865 rs9467645 chr6:25955176 G/C cg17691542 chr6:26056736 HIST1H1C 0.55 8.26 0.41 3.65e-15 Height; CRC cis rs6964587 0.967 rs6980247 chr7:91594228 T/A cg17063962 chr7:91808500 NA 0.83 14.92 0.64 7.97e-39 Breast cancer; CRC cis rs6570726 0.791 rs379040 chr6:145889035 T/C cg13319975 chr6:146136371 FBXO30 -0.4 -5.92 -0.31 8.19e-9 Lobe attachment (rater-scored or self-reported); CRC trans rs9650657 0.513 rs7005884 chr8:10796472 A/G cg08975724 chr8:8085496 FLJ10661 -0.4 -6.01 -0.31 5.04e-9 Neuroticism; CRC cis rs2243480 0.901 rs1701759 chr7:65470932 G/T cg12463550 chr7:65579703 CRCP 0.65 6.2 0.32 1.67e-9 Diabetic kidney disease; CRC cis rs2070488 1.000 rs13079757 chr3:38491444 C/T cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.91 16.81 0.68 3.37e-46 Electrocardiographic conduction measures; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg01678049 chr5:149737331 TCOF1 0.49 6.77 0.35 6.06e-11 Response to antipsychotic treatment; CRC cis rs1799949 1.000 rs3092988 chr17:41201702 C/T cg01879757 chr17:41196368 BRCA1 -0.39 -5.82 -0.31 1.38e-8 Menopause (age at onset); CRC cis rs11971779 0.680 rs12154842 chr7:139078484 A/G cg23387468 chr7:139079360 LUC7L2 0.4 6.96 0.36 1.9e-11 Diisocyanate-induced asthma; CRC cis rs7618915 0.547 rs11130313 chr3:52676190 A/C cg05573699 chr3:52720067 GNL3;PBRM1 -0.47 -6.68 -0.35 1.02e-10 Bipolar disorder; CRC cis rs17376456 0.825 rs10036024 chr5:93074804 C/A cg25358565 chr5:93447407 FAM172A 1.01 9.2 0.45 4.24e-18 Diabetic retinopathy; CRC trans rs931812 0.825 rs55818461 chr8:101899229 T/C cg20993868 chr7:22813445 NA 0.53 9.64 0.47 1.56e-19 Attention deficit hyperactivity disorder and conduct disorder; CRC cis rs11574514 1.000 rs8061384 chr16:67911874 T/G cg26727032 chr16:67993705 SLC12A4 -0.62 -6.02 -0.31 4.73e-9 Crohn's disease; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg05910615 chr19:36248877 HSPB6;C19orf55 0.43 6.75 0.35 6.78e-11 Liver disease severity in Alagille syndrome; CRC cis rs7739232 0.920 rs112460412 chr6:53526863 T/C cg15658676 chr6:53530538 KLHL31 -0.76 -5.9 -0.31 8.9e-9 Hip circumference adjusted for BMI; CRC cis rs6860806 0.661 rs6871350 chr5:131580220 A/G cg18301423 chr5:131593218 PDLIM4 0.38 7.01 0.36 1.32e-11 Breast cancer; CRC cis rs7635838 1.000 rs7635838 chr3:11412604 A/G cg00170343 chr3:11313890 ATG7 0.43 6.42 0.33 4.75e-10 HDL cholesterol; CRC cis rs7666738 0.830 rs7678250 chr4:98922109 G/A cg17366294 chr4:99064904 C4orf37 0.43 7.32 0.37 1.95e-12 Colonoscopy-negative controls vs population controls; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg04607442 chr13:21872219 NA 0.49 7.91 0.4 3.85e-14 Liver disease severity in Alagille syndrome; CRC cis rs1862618 0.802 rs42769 chr5:56144152 G/A cg12311346 chr5:56204834 C5orf35 -0.79 -10.48 -0.5 2.21e-22 Initial pursuit acceleration; CRC cis rs812925 0.502 rs13028833 chr2:61644329 C/G cg10580144 chr2:61372316 C2orf74 -0.32 -6.83 -0.35 4.18e-11 Immature fraction of reticulocytes; CRC cis rs4594175 0.926 rs12434681 chr14:51595335 A/G cg23942311 chr14:51606299 NA 0.67 10.66 0.51 5.51e-23 Cancer; CRC cis rs12325245 0.536 rs3169293 chr16:58552959 A/G cg19824325 chr16:58548873 SETD6 0.92 6.21 0.32 1.62e-9 Schizophrenia; CRC cis rs10256972 0.616 rs4585652 chr7:1145396 A/G cg23978390 chr7:1156363 C7orf50 0.54 7.4 0.38 1.14e-12 Longevity;Endometriosis; CRC cis rs3741798 0.614 rs61922044 chr12:12490914 G/A cg08615371 chr12:12503544 MANSC1 1.1 9.78 0.47 5.37e-20 Cerebrospinal fluid biomarker levels; CRC cis rs2290159 1.000 rs2290159 chr3:12628920 G/C cg23032965 chr3:12705835 RAF1 0.45 5.72 0.3 2.35e-8 Cholesterol, total; CRC cis rs10493773 1.000 rs2274738 chr1:86119898 A/G cg17807903 chr1:86174739 ZNHIT6 -0.48 -9.66 -0.47 1.37e-19 Urate levels in overweight individuals; CRC cis rs7927592 0.871 rs55953412 chr11:68328283 C/T cg16797656 chr11:68205561 LRP5 0.36 5.71 0.3 2.51e-8 Total body bone mineral density; CRC cis rs1129187 1.000 rs1129187 chr6:42932200 G/T cg26304593 chr6:42947056 PEX6 -0.41 -5.88 -0.31 1.02e-8 Alzheimer's disease in APOE e4+ carriers; CRC cis rs2427308 0.643 rs477859 chr20:60937597 A/G cg22601191 chr20:60968625 CABLES2 -0.4 -6.56 -0.34 2.1e-10 Colorectal cancer; CRC cis rs57590327 0.555 rs13099615 chr3:81729101 T/A cg07356753 chr3:81810745 GBE1 -0.65 -8.86 -0.44 5.02e-17 Extraversion; CRC cis rs4731207 0.698 rs7811608 chr7:124447848 T/C cg23710748 chr7:124431027 NA 0.38 6.03 0.32 4.49e-9 Cutaneous malignant melanoma; CRC cis rs9399135 0.967 rs11756988 chr6:135347595 A/G cg22676075 chr6:135203613 NA 0.41 6.38 0.33 5.97e-10 Red blood cell count; CRC trans rs2228479 0.717 rs11649210 chr16:89807233 C/G cg24644049 chr4:85504048 CDS1 0.69 6.17 0.32 2.01e-9 Skin colour saturation; CRC cis rs5167 0.505 rs7257468 chr19:45453144 C/T cg13119609 chr19:45449297 APOC2 0.32 6.02 0.32 4.62e-9 Blood protein levels; CRC cis rs4819052 0.851 rs4819039 chr21:46659458 G/A cg02159808 chr21:46707872 POFUT2;LOC642852 0.49 6.41 0.33 5.19e-10 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs4689388 0.853 rs1079214 chr4:6282157 T/C cg14416269 chr4:6271139 WFS1 0.38 6.14 0.32 2.35e-9 Type 2 diabetes and other traits;Type 2 diabetes; CRC cis rs875971 0.660 rs801192 chr7:66031952 C/G cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.43 -6.31 -0.33 9.14e-10 Aortic root size; CRC cis rs58688157 0.705 rs2396545 chr11:601785 T/C cg16486109 chr11:613632 IRF7 0.7 12.0 0.55 8.89e-28 Systemic lupus erythematosus; CRC cis rs6582630 0.593 rs7134006 chr12:38596245 A/C cg26384229 chr12:38710491 ALG10B 0.67 8.98 0.44 2.06e-17 Drug-induced liver injury (flucloxacillin); CRC cis rs3820068 0.705 rs951225 chr1:15826292 G/A cg27534772 chr1:16042836 PLEKHM2 0.41 6.95 0.36 1.99e-11 Systolic blood pressure; CRC cis rs9322817 0.583 rs7770002 chr6:105173445 A/G cg02098413 chr6:105308735 HACE1 0.35 5.77 0.3 1.8e-8 Thyroid stimulating hormone; CRC cis rs10870270 0.913 rs4880326 chr10:133745547 C/A cg17892150 chr10:133769511 PPP2R2D -0.74 -11.21 -0.53 6.17e-25 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; CRC cis rs875971 0.862 rs778724 chr7:65829291 T/C cg12463550 chr7:65579703 CRCP 0.51 7.24 0.37 3.2e-12 Aortic root size; CRC cis rs6502050 0.799 rs7406257 chr17:80089340 G/A cg11859384 chr17:80120422 CCDC57 -0.37 -5.92 -0.31 7.94e-9 Life satisfaction; CRC cis rs1552244 0.938 rs9873794 chr3:10074153 T/G cg18598329 chr3:10140678 FANCD2;C3orf24 -0.89 -12.68 -0.57 2.75e-30 Alzheimer's disease; CRC cis rs9911578 1.000 rs9915935 chr17:56843048 A/G cg05425664 chr17:57184151 TRIM37 -0.5 -7.81 -0.4 7.69e-14 Intelligence (multi-trait analysis); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg18355925 chr4:56212207 SRD5A3 0.44 6.8 0.35 5.03e-11 Liver disease severity in Alagille syndrome; CRC cis rs12908161 1.000 rs12903134 chr15:85337699 T/A cg11189052 chr15:85197271 WDR73 0.57 8.13 0.41 8.8e-15 Schizophrenia; CRC cis rs10540 1.000 rs35898083 chr11:484469 C/T cg03934478 chr11:495069 RNH1 0.67 7.26 0.37 2.84e-12 Body mass index; CRC trans rs10982213 0.830 rs2274163 chr9:117188714 C/T cg01866215 chr16:3150293 NA -0.47 -7.09 -0.36 8.32e-12 Interleukin-6 levels; CRC cis rs9894429 0.752 rs7502883 chr17:79588557 T/C cg21028142 chr17:79581711 NPLOC4 0.33 6.96 0.36 1.81e-11 Eye color traits; CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg03634887 chr16:66730948 CMTM4 -0.52 -6.19 -0.32 1.83e-9 Diisocyanate-induced asthma; CRC trans rs656319 0.580 rs13252589 chr8:10005526 A/G cg06636001 chr8:8085503 FLJ10661 -0.45 -6.72 -0.35 8.26e-11 Myopia (pathological); CRC cis rs4731207 0.596 rs7810120 chr7:124644945 A/G cg23710748 chr7:124431027 NA -0.39 -6.25 -0.33 1.24e-9 Cutaneous malignant melanoma; CRC cis rs7493 1.000 rs17876123 chr7:95045307 C/A cg07404485 chr7:94953653 PON1 -0.47 -6.15 -0.32 2.26e-9 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs17666538 1.000 rs59631161 chr8:587808 G/T cg02524346 chr8:600233 NA -0.93 -8.26 -0.41 3.66e-15 IgG glycosylation; CRC trans rs11098499 0.738 rs28687057 chr4:120280812 A/G cg25214090 chr10:38739885 LOC399744 0.61 9.66 0.47 1.39e-19 Corneal astigmatism; CRC cis rs853679 0.517 rs9380055 chr6:28081629 A/G cg15786705 chr6:28176104 NA 0.76 9.47 0.46 5.57e-19 Depression; CRC cis rs7918232 0.567 rs4749215 chr10:27312005 T/C cg14240646 chr10:27532245 ACBD5 -0.62 -6.93 -0.36 2.21e-11 Breast cancer; CRC trans rs4942242 0.512 rs9533551 chr13:44187120 G/C cg27382691 chr15:76552771 ETFA;TYRO3P -0.53 -6.77 -0.35 6.1e-11 Response to tocilizumab in rheumatoid arthritis; CRC cis rs2836974 0.865 rs7282624 chr21:40667040 C/T cg11890956 chr21:40555474 PSMG1 1.07 17.99 0.7 6.94e-51 Cognitive function; CRC trans rs8002861 0.626 rs9533634 chr13:44397815 T/C cg17145862 chr1:211918768 LPGAT1 -0.47 -7.82 -0.4 7.28e-14 Leprosy; CRC cis rs1707322 0.686 rs2991986 chr1:46081282 A/G cg06784218 chr1:46089804 CCDC17 -0.65 -11.78 -0.54 5.74e-27 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC trans rs10411161 1.000 rs10412080 chr19:52373508 A/C cg22319618 chr22:45562946 NUP50 -0.54 -6.24 -0.33 1.38e-9 Breast cancer; CRC cis rs921968 0.565 rs6723334 chr2:219629303 C/T cg02176678 chr2:219576539 TTLL4 0.38 6.16 0.32 2.15e-9 Mean corpuscular hemoglobin concentration; CRC cis rs60871478 0.636 rs12534606 chr7:895928 A/G cg05535760 chr7:792225 HEATR2 -0.9 -10.09 -0.49 5.02e-21 Cerebrospinal P-tau181p levels; CRC cis rs6570726 0.791 rs9497357 chr6:145912888 G/A cg23711669 chr6:146136114 FBXO30 0.75 12.57 0.57 7.04e-30 Lobe attachment (rater-scored or self-reported); CRC cis rs4713118 0.784 rs9468219 chr6:27731755 C/A cg03623178 chr6:28175578 NA 0.69 9.22 0.45 3.71e-18 Parkinson's disease; CRC cis rs6460942 0.505 rs73290446 chr7:12358133 T/G cg06484146 chr7:12443880 VWDE -0.53 -5.7 -0.3 2.73e-8 Coronary artery disease; CRC trans rs6598955 0.671 rs11247904 chr1:26621804 G/A cg07461501 chr17:79650226 HGS;ARL16 -0.53 -6.15 -0.32 2.31e-9 Obesity-related traits; CRC cis rs13217239 0.646 rs6456767 chr6:27070543 C/T cg12292205 chr6:26970375 C6orf41 -0.54 -8.91 -0.44 3.67e-17 Schizophrenia; CRC cis rs6121246 0.908 rs6089094 chr20:30431771 C/T cg18721089 chr20:30220636 NA -0.34 -5.72 -0.3 2.34e-8 Mean corpuscular hemoglobin; CRC cis rs924607 1.000 rs1697978 chr5:642829 A/G cg09021430 chr5:549028 NA -0.52 -8.55 -0.43 4.82e-16 Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia; CRC cis rs1448094 0.533 rs2169572 chr12:86170370 G/T cg18827107 chr12:86230957 RASSF9 0.37 5.93 0.31 7.66e-9 Major depressive disorder; CRC cis rs8060686 0.641 rs1125332 chr16:68227780 A/G cg08314208 chr16:67682810 RLTPR -0.54 -5.83 -0.31 1.31e-8 HDL cholesterol;Metabolic syndrome; CRC cis rs10791323 0.569 rs329664 chr11:133754975 G/T cg15485101 chr11:133734466 NA 0.45 8.39 0.42 1.41e-15 Childhood ear infection; CRC cis rs2565722 0.622 rs1937483 chr6:161295598 G/A cg03159191 chr6:161285451 NA -0.39 -6.0 -0.31 5.09e-9 Blood protein levels; CRC trans rs10802346 0.514 rs5024440 chr1:246372608 G/C cg22732515 chr19:44031385 ETHE1 0.61 9.07 0.45 1.1e-17 Fractional exhaled nitric oxide (childhood); CRC cis rs9527 0.544 rs11191549 chr10:104846797 C/T cg15744005 chr10:104629667 AS3MT -0.31 -6.01 -0.31 5.03e-9 Arsenic metabolism; CRC cis rs1218582 0.711 rs4845677 chr1:154838050 C/T cg06221963 chr1:154839813 KCNN3 -0.74 -15.0 -0.64 4.06e-39 Prostate cancer; CRC cis rs10504229 0.906 rs7003285 chr8:58173108 A/G cg01721255 chr8:58191610 C8orf71 0.49 6.17 0.32 2e-9 Developmental language disorder (linguistic errors); CRC cis rs117623576 0.941 rs60146023 chr10:32411515 G/A cg03047570 chr10:32398778 NA -0.76 -8.78 -0.44 8.91e-17 Anti-saccade response; CRC cis rs11969893 0.850 rs12664068 chr6:101362098 G/T cg12253828 chr6:101329408 ASCC3 1.03 7.49 0.38 6.51e-13 Economic and political preferences (immigration/crime); CRC cis rs3749237 0.595 rs11130192 chr3:49467206 C/G cg07636037 chr3:49044803 WDR6 0.56 8.09 0.41 1.15e-14 Resting heart rate; CRC cis rs13108904 0.935 rs3755920 chr4:1243617 T/C cg02018176 chr4:1364513 KIAA1530 0.42 6.96 0.36 1.88e-11 Obesity-related traits; CRC cis rs668210 0.793 rs502363 chr11:65775592 C/T cg02202077 chr11:65769826 EIF1AD;BANF1 0.46 6.08 0.32 3.32e-9 Cerebrospinal fluid biomarker levels; CRC cis rs10504229 0.683 rs6984765 chr8:58127124 T/C cg02290350 chr8:58132656 NA -0.58 -8.16 -0.41 7.29e-15 Developmental language disorder (linguistic errors); CRC trans rs2303319 0.504 rs62189005 chr2:162562386 T/C cg18122310 chr12:50236657 BCDIN3D -0.74 -6.19 -0.32 1.81e-9 Cognitive function; CRC cis rs7849270 1.000 rs10988232 chr9:131915348 G/T cg13538475 chr9:131942899 NA -0.3 -5.88 -0.31 1.02e-8 Blood metabolite ratios; CRC cis rs344364 0.511 rs337286 chr16:1965719 C/T cg00046913 chr16:1877150 HAGH;FAHD1 -0.56 -5.66 -0.3 3.29e-8 Glomerular filtration rate in chronic kidney disease; CRC cis rs3892630 0.878 rs6510277 chr19:33183669 C/A cg22980127 chr19:33182716 NUDT19 0.91 10.99 0.52 3.76e-24 Red blood cell traits; CRC cis rs6504622 0.537 rs1662576 chr17:44996245 C/T cg16759221 chr17:45003025 GOSR2 -0.68 -11.04 -0.52 2.62e-24 Orofacial clefts; CRC cis rs9611519 1.000 rs9611510 chr22:41569124 T/C cg06634786 chr22:41940651 POLR3H -0.45 -5.86 -0.31 1.12e-8 Neuroticism; CRC cis rs9381040 0.655 rs9381031 chr6:41044957 A/T cg09580153 chr6:41068724 NFYA;LOC221442 -0.42 -5.94 -0.31 7.32e-9 Alzheimer's disease (late onset); CRC cis rs9611565 0.694 rs5758368 chr22:41862288 C/T cg17554472 chr22:41940697 POLR3H -0.52 -5.79 -0.3 1.65e-8 Vitiligo; CRC cis rs875971 0.522 rs4718285 chr7:65292005 A/G cg11764359 chr7:65958608 NA 0.51 7.86 0.4 5.44e-14 Aortic root size; CRC trans rs10983614 1.000 rs7867776 chr9:120072627 A/G cg10372701 chr3:142546496 PCOLCE2 0.49 6.62 0.34 1.46e-10 Survival in pancreatic cancer; CRC cis rs7727544 0.904 rs7736102 chr5:131604257 G/A cg09877947 chr5:131593287 PDLIM4 0.36 6.79 0.35 5.24e-11 Blood metabolite levels; CRC cis rs6840360 0.809 rs6847303 chr4:152730221 G/A cg09659197 chr4:152720779 NA -0.44 -9.46 -0.46 5.89e-19 Intelligence (multi-trait analysis); CRC cis rs2842992 0.915 rs1967802 chr6:160097791 G/A cg11366901 chr6:160182831 ACAT2 0.89 11.8 0.55 4.91e-27 Age-related macular degeneration (geographic atrophy); CRC cis rs6912958 0.781 rs2300906 chr6:88207155 G/A cg12350822 chr6:88032061 C6orf162;GJB7 -0.36 -6.72 -0.35 8.02e-11 Monocyte percentage of white cells; CRC cis rs6502050 0.712 rs8077079 chr17:80059011 C/T cg22110888 chr17:80059540 CCDC57 -0.44 -6.79 -0.35 5.37e-11 Life satisfaction; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg22493673 chr1:156711108 MRPL24 0.46 6.8 0.35 4.86e-11 Intelligence (multi-trait analysis); CRC trans rs916888 0.610 rs199454 chr17:44800110 G/A cg07870213 chr5:140052090 DND1 -0.58 -7.82 -0.4 7.25e-14 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs6461049 0.766 rs10256077 chr7:2171450 C/T cg04267008 chr7:1944627 MAD1L1 0.44 6.21 0.32 1.58e-9 Schizophrenia; CRC cis rs11155671 0.530 rs7764376 chr6:150210344 A/G cg13206674 chr6:150067644 NUP43 0.49 7.04 0.36 1.13e-11 Testicular germ cell tumor; CRC cis rs4713118 0.662 rs149946 chr6:27970031 A/C cg12273811 chr6:28175739 NA -0.6 -8.43 -0.42 1.08e-15 Parkinson's disease; CRC cis rs6951245 1.000 rs78896566 chr7:1080182 C/G cg20603222 chr7:1096387 C7orf50;GPR146 -0.68 -7.91 -0.4 4e-14 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC trans rs7819412 0.745 rs6601569 chr8:11073578 C/T cg06636001 chr8:8085503 FLJ10661 -0.55 -8.06 -0.41 1.47e-14 Triglycerides; CRC cis rs7216064 1.000 rs62084246 chr17:65867911 G/C cg12091567 chr17:66097778 LOC651250 -0.67 -7.79 -0.39 8.84e-14 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CRC cis rs1023500 0.573 rs1807494 chr22:42474138 C/G cg15557168 chr22:42548783 NA 0.37 6.36 0.33 6.89e-10 Schizophrenia; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg25987185 chr17:18129087 LLGL1 0.38 6.01 0.31 5e-9 Liver disease severity in Alagille syndrome; CRC trans rs2303319 0.504 rs62188988 chr2:162531068 T/C cg13034943 chr12:132379564 ULK1 -0.68 -5.97 -0.31 6.02e-9 Cognitive function; CRC cis rs644799 0.710 rs56384142 chr11:95502075 G/T cg25622487 chr11:95524042 FAM76B;CEP57 0.79 13.03 0.58 1.44e-31 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs7786808 0.707 rs11770299 chr7:158228822 G/A cg15440763 chr7:158190612 PTPRN2 0.41 6.47 0.34 3.46e-10 Obesity-related traits; CRC cis rs1018836 0.851 rs7004287 chr8:91620842 G/C cg16814680 chr8:91681699 NA -0.78 -12.43 -0.57 2.47e-29 Ejection fraction in Tripanosoma cruzi seropositivity; CRC trans rs2727020 0.658 rs10839269 chr11:49385596 A/G cg11707556 chr5:10655725 ANKRD33B -0.38 -7.21 -0.37 3.97e-12 Coronary artery disease; CRC trans rs4711350 1.000 rs751727 chr6:33764158 A/G cg14318858 chr19:50204862 CPT1C -0.37 -6.07 -0.32 3.47e-9 Schizophrenia; CRC cis rs10857712 0.703 rs12253520 chr10:135235321 C/A cg01444801 chr10:135216882 MTG1 -0.55 -7.84 -0.4 6.2e-14 Systemic lupus erythematosus; CRC cis rs2982552 0.775 rs2982562 chr6:152052601 C/T cg22157087 chr6:152012887 ESR1 0.38 5.87 0.31 1.07e-8 Bone properties (heel); CRC cis rs10504229 0.683 rs11775568 chr8:58133762 G/A cg02290350 chr8:58132656 NA -0.59 -7.14 -0.37 6.05e-12 Developmental language disorder (linguistic errors); CRC cis rs9650657 0.504 rs10108347 chr8:11033517 G/C cg27411982 chr8:10470053 RP1L1 -0.35 -5.72 -0.3 2.34e-8 Neuroticism; CRC cis rs10461617 0.617 rs6874733 chr5:56069600 A/G cg20203395 chr5:56204925 C5orf35 -0.51 -6.32 -0.33 8.62e-10 Type 2 diabetes; CRC cis rs9443645 0.509 rs9361459 chr6:79572922 A/G cg09184832 chr6:79620586 NA 0.36 6.0 0.31 5.16e-9 Intelligence (multi-trait analysis); CRC trans rs2832077 0.689 rs2832052 chr21:30130073 G/C cg14791747 chr16:20752902 THUMPD1 0.49 7.21 0.37 3.85e-12 Cognitive test performance; CRC cis rs2050392 0.760 rs10826797 chr10:30690376 A/C cg18806716 chr10:30721971 MAP3K8 -0.66 -9.73 -0.47 7.94e-20 Inflammatory bowel disease; CRC cis rs977987 0.966 rs11643207 chr16:75498793 C/T cg03315344 chr16:75512273 CHST6 0.57 9.69 0.47 1.04e-19 Dupuytren's disease; CRC trans rs7618501 1.000 rs4855862 chr3:49748833 C/T cg21665057 chr3:196295764 WDR53;FBXO45 -0.86 -16.09 -0.66 2.29e-43 Intelligence (multi-trait analysis); CRC cis rs1801251 1.000 rs7578299 chr2:233573469 G/T cg25237894 chr2:233734115 C2orf82 0.53 8.53 0.43 5.46e-16 Coronary artery disease; CRC cis rs314370 0.951 rs13226502 chr7:100506381 C/T cg10426581 chr7:100472382 SRRT 0.63 7.24 0.37 3.24e-12 Resting heart rate; CRC cis rs6502050 0.805 rs7406682 chr17:80084368 C/T cg11859384 chr17:80120422 CCDC57 0.37 5.82 0.31 1.36e-8 Life satisfaction; CRC cis rs7923609 0.902 rs10822182 chr10:65325478 G/A cg08743896 chr10:65200160 JMJD1C -0.41 -5.81 -0.3 1.51e-8 Educational attainment;Liver enzyme levels (alkaline phosphatase); CRC cis rs9311676 0.632 rs6445978 chr3:58379586 T/A cg06643156 chr3:58380774 PXK 0.41 6.33 0.33 7.92e-10 Systemic lupus erythematosus; CRC cis rs10504073 0.647 rs59064792 chr8:50018337 A/C cg00325661 chr8:49890786 NA 0.47 8.43 0.42 1.08e-15 Blood metabolite ratios; CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg02326931 chr13:37572901 ALG5 -0.52 -6.13 -0.32 2.46e-9 Diisocyanate-induced asthma; CRC cis rs2882667 0.690 rs825672 chr5:138095643 A/G cg09476006 chr5:138032270 NA -0.53 -8.98 -0.44 2.14e-17 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs4474465 0.920 rs10899527 chr11:78207394 A/G cg27205649 chr11:78285834 NARS2 0.47 5.79 0.3 1.61e-8 Alzheimer's disease (survival time); CRC trans rs944990 0.595 rs10123378 chr9:96375217 C/T cg22349126 chr12:25348261 LYRM5;CASC1 0.39 6.0 0.31 5.17e-9 Body mass index; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg14509581 chr15:68522181 CLN6 0.39 6.21 0.32 1.63e-9 Liver disease severity in Alagille syndrome; CRC cis rs45509595 0.841 rs401754 chr6:27782538 T/A cg23259851 chr6:27775964 HIST1H2AI;HIST1H2BL 0.71 5.93 0.31 7.74e-9 Breast cancer; CRC cis rs12580194 0.630 rs60586348 chr12:55745151 A/T cg19537932 chr12:55886519 OR6C68 -0.72 -9.1 -0.45 9.11e-18 Cancer; CRC cis rs2991971 0.967 rs12743512 chr1:45954033 A/G cg15605315 chr1:45957053 TESK2 -0.43 -6.83 -0.35 4.13e-11 High light scatter reticulocyte count; CRC cis rs17376456 0.877 rs28418572 chr5:93144161 A/C cg21475434 chr5:93447410 FAM172A 0.71 7.05 0.36 1.09e-11 Diabetic retinopathy; CRC cis rs2576037 0.526 rs6507714 chr18:44519574 A/G cg23996704 chr18:44553084 KATNAL2 -0.31 -5.83 -0.31 1.29e-8 Personality dimensions; CRC cis rs6681460 1.000 rs964574 chr1:67062885 T/C cg02459107 chr1:67143332 SGIP1 0.48 8.21 0.41 5.25e-15 Presence of antiphospholipid antibodies; CRC cis rs780096 0.546 rs715325 chr2:27725572 C/A cg12000995 chr2:27665139 KRTCAP3 -0.31 -6.5 -0.34 2.99e-10 Total body bone mineral density; CRC cis rs9914988 0.887 rs12451790 chr17:27112000 C/G cg12682573 chr17:27188876 MIR451;MIR144 0.58 7.99 0.4 2.37e-14 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs8141797 1.000 rs115965884 chr22:24594662 C/T cg20894457 chr22:24584366 SUSD2 0.66 6.75 0.35 6.71e-11 Amyotrophic lateral sclerosis;Coronary artery disease; CRC cis rs2976388 1.000 rs2976394 chr8:143763622 C/T cg04969067 chr8:143858791 LYNX1 -0.34 -5.82 -0.31 1.38e-8 Urinary tract infection frequency; CRC cis rs4689388 0.926 rs9998835 chr4:6293237 C/G cg00701064 chr4:6280414 WFS1 0.74 12.81 0.58 9.59e-31 Type 2 diabetes and other traits;Type 2 diabetes; CRC cis rs365302 0.904 rs422232 chr6:159649745 A/G cg14500486 chr6:159655392 FNDC1 0.44 6.82 0.35 4.31e-11 Coronary heart disease; CRC trans rs2727020 0.634 rs11040331 chr11:49345726 T/C cg03929089 chr4:120376271 NA -0.65 -8.23 -0.41 4.29e-15 Coronary artery disease; CRC trans rs1493916 0.744 rs7504560 chr18:31312148 A/G cg27147174 chr7:100797783 AP1S1 -0.37 -6.05 -0.32 3.93e-9 Life satisfaction; CRC trans rs2228479 0.867 rs76885005 chr16:89966668 A/G cg24644049 chr4:85504048 CDS1 0.71 6.62 0.34 1.44e-10 Skin colour saturation; CRC cis rs172166 0.561 rs149971 chr6:27982152 G/A cg12273811 chr6:28175739 NA 0.45 6.58 0.34 1.81e-10 Cardiac Troponin-T levels; CRC trans rs7546 0.501 rs12102426 chr16:4922450 T/G cg19252218 chr17:41477271 ARL4D 0.44 6.37 0.33 6.21e-10 Cancer; CRC cis rs801193 1.000 rs1553609 chr7:66197139 T/C cg05627663 chr7:65219948 SNORA22;CCT6P1 0.42 6.12 0.32 2.6e-9 Aortic root size; CRC cis rs12497850 0.931 rs6442130 chr3:48778027 A/G cg20833759 chr3:49053208 WDR6;DALRD3 0.53 9.0 0.44 1.78e-17 Parkinson's disease; CRC cis rs2637266 0.739 rs11001838 chr10:78376351 T/G cg18941641 chr10:78392320 NA -0.37 -6.37 -0.33 6.51e-10 Pulmonary function; CRC cis rs11785693 0.909 rs11784246 chr8:4970497 A/G cg26367366 chr8:4980734 NA 0.76 9.2 0.45 4.29e-18 Neuroticism (multi-trait analysis);Neuroticism; CRC cis rs4665809 0.590 rs13016300 chr2:26468365 G/C cg04944784 chr2:26401820 FAM59B 0.83 10.74 0.51 2.96e-23 Gut microbiome composition (summer); CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg25964984 chr22:30783371 RNF215 -0.4 -6.09 -0.32 3.07e-9 Myopia (pathological); CRC cis rs6866344 0.570 rs4266420 chr5:178137161 C/G cg10224037 chr5:178157518 ZNF354A 0.78 11.62 0.54 2.16e-26 Neutrophil percentage of white cells; CRC trans rs2727020 0.755 rs652655 chr11:49251293 G/A cg03929089 chr4:120376271 NA 0.82 13.85 0.61 1.07e-34 Coronary artery disease; CRC cis rs477692 0.612 rs58103386 chr10:131319958 C/A cg05714579 chr10:131428358 MGMT 0.5 6.99 0.36 1.54e-11 Response to temozolomide; CRC trans rs11098499 0.954 rs2306455 chr4:120421969 G/A cg25214090 chr10:38739885 LOC399744 0.65 10.15 0.49 3.02e-21 Corneal astigmatism; CRC cis rs7786808 0.504 rs10949725 chr7:158196003 C/T cg09998033 chr7:158218633 PTPRN2 0.5 7.05 0.36 1.04e-11 Obesity-related traits; CRC cis rs9611565 0.659 rs17367849 chr22:41923644 G/A cg06481639 chr22:41940642 POLR3H -0.55 -6.33 -0.33 7.89e-10 Vitiligo; CRC cis rs13256369 0.802 rs11249885 chr8:8562008 C/T cg00074818 chr8:8560427 CLDN23 0.32 5.71 0.3 2.55e-8 Obesity-related traits; CRC cis rs6456156 0.792 rs10946215 chr6:167516181 A/G cg07513332 chr6:167530253 CCR6 -0.37 -6.1 -0.32 3.03e-9 Primary biliary cholangitis; CRC cis rs6942756 1.000 rs68076553 chr7:128959632 A/G cg02491457 chr7:128862824 NA -0.73 -9.8 -0.48 4.73e-20 White matter hyperintensity burden; CRC cis rs9611565 0.918 rs12484074 chr22:41752747 G/A cg03806693 chr22:41940476 POLR3H -1.0 -12.82 -0.58 8.38e-31 Vitiligo; CRC trans rs3780486 0.505 rs10813959 chr9:33166234 C/T cg20290983 chr6:43655470 MRPS18A -0.91 -17.02 -0.68 5.07e-47 IgG glycosylation; CRC cis rs7149337 0.836 rs4901087 chr14:51668499 T/C cg23942311 chr14:51606299 NA 0.75 13.98 0.61 3.62e-35 Cancer; CRC cis rs12701220 0.503 rs13222294 chr7:1172969 G/A cg26769984 chr7:1090371 C7orf50 0.47 6.05 0.32 3.87e-9 Bronchopulmonary dysplasia; CRC cis rs4862750 0.794 rs1030382 chr4:187903782 T/G cg10295955 chr4:187884368 NA -1.09 -27.79 -0.84 2.55e-88 Lobe attachment (rater-scored or self-reported); CRC cis rs10504229 0.639 rs11781834 chr8:58133422 C/T cg21724239 chr8:58056113 NA 0.46 6.28 0.33 1.04e-9 Developmental language disorder (linguistic errors); CRC cis rs9900062 0.586 rs12600679 chr17:62687327 T/G cg02097616 chr17:62675921 NA 0.51 7.19 0.37 4.39e-12 QT interval; CRC cis rs524023 1.000 rs11602903 chr11:64358241 A/T cg06522879 chr11:64358276 SLC22A12 -0.59 -9.38 -0.46 1.11e-18 Urate levels in obese individuals; CRC cis rs6951245 1.000 rs76214082 chr7:1102097 T/A cg20603222 chr7:1096387 C7orf50;GPR146 -0.72 -8.66 -0.43 2.19e-16 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs9807989 0.811 rs67088699 chr2:102968751 C/T cg03938978 chr2:103052716 IL18RAP 0.36 5.92 0.31 7.92e-9 Asthma; CRC cis rs9916302 0.904 rs12452880 chr17:37591149 G/C cg03013999 chr17:37608204 MED1 0.47 7.26 0.37 2.88e-12 Glomerular filtration rate (creatinine); CRC cis rs7659604 1.000 rs6816071 chr4:122665185 G/A cg19748678 chr4:122722346 EXOSC9 0.56 8.97 0.44 2.3e-17 Type 2 diabetes; CRC cis rs1448094 0.935 rs4919775 chr12:86339985 T/C cg19622623 chr12:86230825 RASSF9 -0.36 -5.94 -0.31 7.17e-9 Major depressive disorder; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg17705056 chr18:77711560 PQLC1 0.43 7.18 0.37 4.53e-12 Liver disease severity in Alagille syndrome; CRC cis rs12410462 0.681 rs12401677 chr1:227608577 T/C cg04117972 chr1:227635322 NA 0.77 8.03 0.4 1.73e-14 Major depressive disorder; CRC cis rs11098499 0.789 rs10212719 chr4:120254437 T/C cg09307838 chr4:120376055 NA 0.6 9.2 0.45 4.34e-18 Corneal astigmatism; CRC cis rs2645694 0.626 rs2703116 chr4:77824289 C/T cg03477792 chr4:77819574 ANKRD56 -0.42 -6.13 -0.32 2.58e-9 Emphysema distribution in smoking; CRC cis rs9486719 0.948 rs2499817 chr6:96878321 C/T cg06623918 chr6:96969491 KIAA0776 0.81 9.51 0.46 4.17e-19 Migraine;Coronary artery disease; CRC cis rs798554 0.680 rs1713912 chr7:2895784 C/A cg13628971 chr7:2884303 GNA12 0.56 7.83 0.4 6.99e-14 Height; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg10518340 chr6:97731094 MIR548H3;C6orf167 0.52 7.28 0.37 2.44e-12 Anxiety disorder; CRC cis rs4920343 0.645 rs851115 chr1:19070229 T/A cg19637330 chr1:19110922 NA 0.4 6.12 0.32 2.65e-9 Knee osteoarthritis; CRC cis rs1552244 1.000 rs113153120 chr3:10156398 G/A cg13047869 chr3:10149882 C3orf24 0.58 7.85 0.4 5.85e-14 Alzheimer's disease; CRC trans rs9388451 0.839 rs4897155 chr6:126095144 C/A cg05039488 chr6:79577232 IRAK1BP1 -0.55 -8.37 -0.42 1.69e-15 Brugada syndrome; CRC cis rs796364 1.000 rs281763 chr2:200794870 C/T cg12253985 chr2:200820533 C2orf60;C2orf47 0.6 6.61 0.34 1.58e-10 Schizophrenia; CRC cis rs7119 0.717 rs12904348 chr15:77815738 G/C cg27398640 chr15:77910606 LINGO1 -0.44 -7.81 -0.4 7.8e-14 Type 2 diabetes; CRC cis rs853679 0.517 rs9368550 chr6:28051803 T/A cg21251018 chr6:28226885 NKAPL 0.48 6.29 0.33 9.93e-10 Depression; CRC cis rs3751196 0.901 rs79261387 chr12:104161484 T/C cg02344784 chr12:104178138 NT5DC3 0.68 6.76 0.35 6.18e-11 Sense of smell; CRC cis rs10924970 0.967 rs12035746 chr1:235405654 C/T cg26050004 chr1:235667680 B3GALNT2 0.39 5.78 0.3 1.71e-8 Asthma; CRC cis rs6502050 0.835 rs62078306 chr17:80085341 A/G cg19223190 chr17:80058835 NA -0.39 -6.24 -0.33 1.31e-9 Life satisfaction; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg05447486 chr1:112162367 RAP1A 0.42 6.53 0.34 2.42e-10 Liver disease severity in Alagille syndrome; CRC cis rs1448094 0.512 rs12297441 chr12:86233980 C/T cg19622623 chr12:86230825 RASSF9 -0.39 -6.41 -0.33 4.97e-10 Major depressive disorder; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg21909475 chr1:169764459 C1orf156;C1orf112 0.41 6.02 0.31 4.62e-9 Liver disease severity in Alagille syndrome; CRC cis rs3733585 0.699 rs28837683 chr4:9959808 C/T cg00071950 chr4:10020882 SLC2A9 -0.55 -9.92 -0.48 1.83e-20 Cleft plate (environmental tobacco smoke interaction); CRC cis rs1997103 1.000 rs6953509 chr7:55412179 G/A cg17469321 chr7:55412551 NA 0.72 11.16 0.52 9.35e-25 QRS interval (sulfonylurea treatment interaction); CRC cis rs2404602 0.684 rs11072600 chr15:76867915 T/C cg23625390 chr15:77176239 SCAPER -0.86 -14.19 -0.62 5.52e-36 Blood metabolite levels; CRC cis rs2836974 0.568 rs414850 chr21:40543337 A/C cg22974920 chr21:40686053 BRWD1 0.42 5.98 0.31 5.79e-9 Cognitive function; CRC cis rs4243830 0.850 rs3761927 chr1:6601773 T/C cg15205204 chr1:6545172 PLEKHG5 0.38 5.66 0.3 3.22e-8 Body mass index; CRC cis rs6938 0.534 rs7495739 chr15:75185670 C/T cg17294928 chr15:75287854 SCAMP5 -0.51 -7.63 -0.39 2.5e-13 Breast cancer; CRC trans rs2303319 0.504 rs1006428 chr2:162592559 A/C cg20024234 chr21:43431083 ZNF295 -0.66 -5.99 -0.31 5.57e-9 Cognitive function; CRC cis rs6964587 1.000 rs7791138 chr7:91686789 A/G cg17063962 chr7:91808500 NA 0.82 14.61 0.63 1.28e-37 Breast cancer; CRC cis rs7044106 0.762 rs10739570 chr9:123381222 C/T cg09419670 chr9:123605666 PSMD5;LOC253039 0.71 11.77 0.54 6.2e-27 Hip circumference adjusted for BMI; CRC cis rs1218582 0.710 rs4845687 chr1:154878911 A/G cg06221963 chr1:154839813 KCNN3 -0.76 -15.38 -0.65 1.34e-40 Prostate cancer; CRC cis rs2749592 0.550 rs7081464 chr10:37883937 C/T cg25517755 chr10:38738941 LOC399744 0.4 5.81 0.31 1.47e-8 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs28374715 0.681 rs28728213 chr15:41653602 T/A cg18705301 chr15:41695430 NDUFAF1 -0.88 -14.49 -0.62 3.75e-37 Ulcerative colitis; CRC cis rs3785574 0.924 rs2727292 chr17:61893747 A/G cg06873352 chr17:61820015 STRADA 0.49 7.77 0.39 1e-13 Height; CRC cis rs11650494 0.908 rs75092916 chr17:47412578 T/C cg08112188 chr17:47440006 ZNF652 1.26 11.71 0.54 1.03e-26 Prostate cancer; CRC cis rs6426558 0.537 rs6699828 chr1:227274591 T/C cg10327440 chr1:227177885 CDC42BPA 0.44 6.58 0.34 1.83e-10 Neutrophil percentage of white cells; CRC cis rs9309473 0.583 rs11899517 chr2:73573261 A/G cg20560298 chr2:73613845 ALMS1 -0.5 -6.77 -0.35 5.77e-11 Metabolite levels; CRC cis rs954108 0.966 rs9508155 chr13:29372016 C/T cg11788234 chr13:29393811 NA 0.43 7.26 0.37 2.78e-12 Obesity-related traits; CRC cis rs1552244 0.832 rs67145301 chr3:10197314 G/A cg10729496 chr3:10149963 C3orf24 0.62 7.31 0.37 2.04e-12 Alzheimer's disease; CRC cis rs10744422 0.748 rs2292138 chr12:123339712 A/G cg25930673 chr12:123319894 HIP1R -0.61 -6.4 -0.33 5.25e-10 Schizophrenia; CRC cis rs875971 0.965 rs7794930 chr7:65778546 A/C cg11764359 chr7:65958608 NA -0.61 -9.68 -0.47 1.19e-19 Aortic root size; CRC cis rs910187 0.624 rs6066219 chr20:45793967 A/T cg27589058 chr20:45804311 EYA2 -0.36 -6.67 -0.35 1.07e-10 Migraine; CRC cis rs6866344 0.697 rs11742808 chr5:178131658 G/A cg03877680 chr5:178157825 ZNF354A 0.76 10.57 0.5 1.16e-22 Neutrophil percentage of white cells; CRC cis rs9303280 0.806 rs34189114 chr17:38032460 C/T cg11212589 chr17:38028394 ZPBP2 0.43 7.93 0.4 3.36e-14 Self-reported allergy; CRC cis rs2404602 0.735 rs11637490 chr15:76759565 A/G cg03037974 chr15:76606532 NA -0.55 -8.25 -0.41 3.89e-15 Blood metabolite levels; CRC cis rs8180040 0.768 rs11915074 chr3:47309757 A/T cg10298567 chr3:47292165 KIF9 0.41 6.37 0.33 6.28e-10 Colorectal cancer; CRC trans rs57221529 0.766 rs12518859 chr5:587432 C/T cg25482853 chr8:67687455 SGK3 1.25 15.0 0.64 4.06e-39 Lung disease severity in cystic fibrosis; CRC cis rs6772849 0.708 rs12491942 chr3:128421469 C/G cg08795948 chr3:128337044 NA 0.34 5.67 0.3 3.12e-8 Monocyte percentage of white cells;Monocyte count; CRC cis rs9814567 1.000 rs4417907 chr3:134291363 C/T cg06109529 chr3:134205091 CEP63;ANAPC13 -0.82 -12.47 -0.57 1.66e-29 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs7412746 0.658 rs4970986 chr1:150907955 A/G cg18016565 chr1:150552671 MCL1 0.42 6.06 0.32 3.8e-9 Melanoma; CRC cis rs7811142 0.943 rs28578163 chr7:100044754 A/G cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.76 10.89 0.51 8.98e-24 Platelet count; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg05563107 chr19:50528575 VRK3;ZNF473 0.5 6.93 0.36 2.27e-11 Response to antipsychotic treatment; CRC cis rs9322193 0.926 rs9766562 chr6:150109845 C/G cg13206674 chr6:150067644 NUP43 0.57 8.16 0.41 7.21e-15 Lung cancer; CRC trans rs11722228 0.522 rs2241468 chr4:10113905 G/A cg26043149 chr18:55253948 FECH 1.15 17.21 0.69 8.7e-48 Gout;Urate levels;Serum uric acid levels; CRC cis rs1552244 1.000 rs7610821 chr3:10136150 C/T cg18598329 chr3:10140678 FANCD2;C3orf24 -0.91 -13.32 -0.59 1.11e-32 Alzheimer's disease; CRC cis rs12230513 0.732 rs61956331 chr12:55840856 G/A cg19537932 chr12:55886519 OR6C68 -0.73 -9.5 -0.46 4.47e-19 Contrast sensitivity; CRC cis rs9287719 0.649 rs11684537 chr2:10734832 C/T cg00105475 chr2:10696890 NA 0.44 7.02 0.36 1.27e-11 Prostate cancer; CRC cis rs763121 0.853 rs2281020 chr22:39064406 A/G cg06022373 chr22:39101656 GTPBP1 0.8 12.71 0.57 2.19e-30 Menopause (age at onset); CRC cis rs644799 0.965 rs602512 chr11:95561682 G/A cg25478527 chr11:95522999 CEP57;FAM76B 0.53 7.98 0.4 2.44e-14 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs6860806 0.507 rs272882 chr5:131669161 G/T cg27615366 chr5:131592974 PDLIM4 0.32 5.73 0.3 2.22e-8 Breast cancer; CRC cis rs35110281 0.712 rs8133523 chr21:45062403 A/G cg01579765 chr21:45077557 HSF2BP -0.39 -7.63 -0.39 2.56e-13 Mean corpuscular volume; CRC cis rs367943 1.000 rs1057827 chr5:112823768 T/C cg12552261 chr5:112820674 MCC 0.49 7.52 0.38 5.23e-13 Type 2 diabetes; CRC trans rs7178691 0.705 rs2899517 chr15:53892200 A/C cg05337636 chr17:78720537 RPTOR -0.48 -6.32 -0.33 8.48e-10 Fear of severe pain; CRC cis rs4713118 0.513 rs149897 chr6:28006650 A/G cg03623178 chr6:28175578 NA 0.78 11.7 0.54 1.1e-26 Parkinson's disease; CRC cis rs1881797 1.000 rs12063141 chr1:247688343 G/A cg18198730 chr1:247681584 NA 0.59 8.95 0.44 2.62e-17 Acute lymphoblastic leukemia (childhood); CRC cis rs4713118 0.513 rs156734 chr6:28007357 A/C cg02631126 chr6:28058918 ZSCAN12L1 0.24 5.64 0.3 3.61e-8 Parkinson's disease; CRC cis rs939584 1.000 rs7591067 chr2:642846 G/A cg03610516 chr2:642275 NA 0.42 5.88 0.31 9.94e-9 Body mass index; CRC cis rs9905704 0.918 rs304272 chr17:56803028 C/A cg12560992 chr17:57184187 TRIM37 0.53 7.37 0.38 1.41e-12 Testicular germ cell tumor; CRC cis rs637571 0.546 rs11227311 chr11:65585257 C/A cg26695010 chr11:65641043 EFEMP2 0.51 7.61 0.39 3.01e-13 Eosinophil percentage of white cells; CRC cis rs4919694 0.901 rs12264456 chr10:104830634 C/T cg04362960 chr10:104952993 NT5C2 1.11 10.43 0.5 3.33e-22 Arsenic metabolism; CRC cis rs801193 1.000 rs7782320 chr7:66177098 C/T cg11764359 chr7:65958608 NA 0.55 8.56 0.43 4.49e-16 Aortic root size; CRC cis rs7945705 0.774 rs6486060 chr11:9024630 A/G cg12365402 chr11:9010492 NRIP3 0.47 8.08 0.41 1.26e-14 Hemoglobin concentration; CRC cis rs10911363 0.659 rs6669960 chr1:183436577 C/G cg09173681 chr1:183549694 NCF2 -0.76 -10.28 -0.49 1.14e-21 Systemic lupus erythematosus; CRC cis rs9372498 0.536 rs9489395 chr6:118758884 T/C cg22561889 chr6:118971681 C6orf204 0.53 6.87 0.35 3.16e-11 Diastolic blood pressure; CRC cis rs853679 0.517 rs9357063 chr6:28060005 G/A cg18032046 chr6:28092343 ZSCAN16 -0.5 -5.79 -0.3 1.67e-8 Depression; CRC cis rs4285028 0.948 rs2091664 chr3:121684749 T/A cg20356878 chr3:121714668 ILDR1 -0.48 -6.95 -0.36 1.93e-11 Multiple sclerosis; CRC cis rs1552244 1.000 rs28684871 chr3:10072635 C/A cg16606324 chr3:10149918 C3orf24 0.68 9.17 0.45 5.33e-18 Alzheimer's disease; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg02537149 chr1:46769035 LRRC41;UQCRH 0.43 6.33 0.33 8.06e-10 Intelligence (multi-trait analysis); CRC cis rs644799 1.000 rs564675 chr11:95561873 C/T cg03916912 chr11:95522834 CEP57;FAM76B 0.95 18.38 0.71 2.03e-52 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg00763555 chr13:30881437 KATNAL1 0.51 6.59 0.34 1.73e-10 Thyroid stimulating hormone; CRC cis rs17376456 0.825 rs10036024 chr5:93074804 C/A cg21475434 chr5:93447410 FAM172A 0.7 6.47 0.34 3.56e-10 Diabetic retinopathy; CRC cis rs6714710 0.603 rs2044459 chr2:98447004 T/C cg26665480 chr2:98280029 ACTR1B 0.53 7.27 0.37 2.59e-12 Posterior cortical atrophy and Alzheimer's disease; CRC cis rs6546550 0.901 rs6546556 chr2:70139001 A/G cg02498382 chr2:70120550 SNRNP27 -0.56 -9.52 -0.46 3.78e-19 Prevalent atrial fibrillation; CRC cis rs8180040 0.966 rs17476234 chr3:47326298 G/A cg27129171 chr3:47204927 SETD2 -0.66 -10.09 -0.49 5.03e-21 Colorectal cancer; CRC cis rs60843830 0.928 rs2306060 chr2:230912 A/C cg25945732 chr2:264204 ACP1;SH3YL1 0.73 12.16 0.56 2.32e-28 Spherical equivalent (joint analysis main effects and education interaction); CRC cis rs2839186 0.588 rs7280110 chr21:47619039 G/A cg09417038 chr21:47716443 C21orf57 0.38 6.64 0.34 1.3100000000000001e-10 Testicular germ cell tumor; CRC cis rs672059 0.812 rs61418038 chr1:183155717 C/A ch.1.3577855R chr1:183094577 LAMC1 0.51 7.33 0.37 1.79e-12 Hypertriglyceridemia; CRC cis rs6752107 1.000 rs6431654 chr2:234161769 C/T cg07618928 chr2:234183455 ATG16L1;SCARNA5 0.66 11.79 0.55 5.15e-27 Crohn's disease;Inflammatory bowel disease; CRC cis rs10751667 0.961 rs7396670 chr11:929269 A/G cg23136738 chr11:925521 AP2A2 -0.5 -7.92 -0.4 3.57e-14 Alzheimer's disease (late onset); CRC cis rs6502050 0.731 rs9891378 chr17:80116035 T/C cg13198984 chr17:80129470 CCDC57 0.46 8.18 0.41 6.3e-15 Life satisfaction; CRC cis rs1862618 0.620 rs2591967 chr5:56233551 C/G cg24531977 chr5:56204891 C5orf35 0.68 10.33 0.49 7.34e-22 Initial pursuit acceleration; CRC cis rs875971 0.964 rs6945032 chr7:65922486 C/T cg12463550 chr7:65579703 CRCP 0.48 6.78 0.35 5.54e-11 Aortic root size; CRC cis rs7617773 0.643 rs78159520 chr3:48349023 T/C cg11946769 chr3:48343235 NME6 0.73 9.74 0.47 7.29e-20 Coronary artery disease; CRC cis rs863345 0.604 rs1342947 chr1:158459714 G/A cg12129480 chr1:158549410 OR10X1 -0.29 -6.04 -0.32 4.2e-9 Pneumococcal bacteremia; CRC cis rs3204270 0.759 rs62075725 chr17:79611510 A/G cg09655341 chr17:79618100 PDE6G 0.64 7.68 0.39 1.79e-13 Dental caries; CRC cis rs2535633 0.631 rs11915851 chr3:53096047 C/T cg11645453 chr3:52864694 ITIH4 0.42 7.25 0.37 3.09e-12 Body mass index; CRC cis rs6952808 0.929 rs12699483 chr7:1975624 C/G cg21782813 chr7:2030301 MAD1L1 0.47 7.51 0.38 5.73e-13 Bipolar disorder and schizophrenia; CRC cis rs7638909 0.512 rs6799868 chr3:38601556 T/C cg01465620 chr3:38496096 LOC100128640;ACVR2B -0.5 -7.08 -0.36 8.7e-12 Electrocardiographic conduction measures; CRC cis rs9381040 0.610 rs9367094 chr6:41017860 T/C cg09580153 chr6:41068724 NFYA;LOC221442 -0.42 -6.17 -0.32 1.96e-9 Alzheimer's disease (late onset); CRC cis rs7927771 0.965 rs35184771 chr11:47475189 G/T cg18512352 chr11:47633146 NA -0.48 -9.31 -0.46 1.94e-18 Subjective well-being; CRC cis rs1348850 0.526 rs935426 chr2:178369433 T/C cg27490568 chr2:178487706 NA 0.57 7.07 0.36 9.44e-12 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs6840360 0.967 rs10028410 chr4:152606573 T/C cg09659197 chr4:152720779 NA 0.51 11.13 0.52 1.27e-24 Intelligence (multi-trait analysis); CRC trans rs11098499 0.820 rs2389885 chr4:120533931 C/T cg25214090 chr10:38739885 LOC399744 0.65 9.42 0.46 8.15e-19 Corneal astigmatism; CRC trans rs3942852 0.550 rs1113480 chr11:48058313 G/T cg15704280 chr7:45808275 SEPT13 -0.58 -8.03 -0.4 1.75e-14 Acute lymphoblastic leukemia (childhood); CRC cis rs3796619 0.503 rs1466216 chr4:1071907 C/T cg27284194 chr4:1044797 NA -0.59 -10.08 -0.49 5.24e-21 Recombination rate (males); CRC cis rs921968 0.541 rs636723 chr2:219373197 A/G cg02176678 chr2:219576539 TTLL4 0.54 8.69 0.43 1.78e-16 Mean corpuscular hemoglobin concentration; CRC cis rs4900538 0.855 rs12587464 chr14:102886561 G/C cg18135206 chr14:102964638 TECPR2 -0.97 -17.42 -0.69 1.34e-48 Mean corpuscular volume;Mean corpuscular hemoglobin; CRC cis rs208520 0.560 rs2351880 chr6:66863707 G/A cg07460842 chr6:66804631 NA -1.07 -14.84 -0.63 1.64e-38 Exhaled nitric oxide output; CRC cis rs875971 1.000 rs10215948 chr7:65747786 G/A cg12463550 chr7:65579703 CRCP -0.48 -6.86 -0.35 3.42e-11 Aortic root size; CRC cis rs4713118 0.516 rs4713142 chr6:28106347 T/G cg12172441 chr6:28176163 NA 0.62 7.4 0.38 1.17e-12 Parkinson's disease; CRC cis rs7493 0.950 rs7785846 chr7:95033841 C/T cg04155289 chr7:94953770 PON1 -0.6 -7.53 -0.38 4.89e-13 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs4692589 0.581 rs62344679 chr4:170963591 G/A cg19918862 chr4:170955249 NA 0.53 7.01 0.36 1.35e-11 Anxiety disorder; CRC cis rs3812111 0.524 rs12193094 chr6:116540395 C/T cg15226275 chr6:116381976 FRK 0.26 6.1 0.32 3.06e-9 Age-related macular degeneration; CRC trans rs6550704 0.687 rs9865314 chr3:22634337 A/G cg16419706 chr3:141596184 ATP1B3 -0.42 -6.12 -0.32 2.59e-9 Daytime sleep phenotypes; CRC cis rs7617773 0.817 rs9819094 chr3:48319558 C/T cg11946769 chr3:48343235 NME6 0.6 8.07 0.41 1.34e-14 Coronary artery disease; CRC cis rs10782582 0.609 rs1796815 chr1:76396793 T/G cg03433033 chr1:76189801 ACADM -0.41 -5.77 -0.3 1.8e-8 Daytime sleep phenotypes; CRC cis rs6570726 0.846 rs441575 chr6:145849205 A/C cg05347473 chr6:146136440 FBXO30 0.38 6.09 0.32 3.19e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs7769051 0.711 rs9493435 chr6:133088205 A/G cg07930552 chr6:133119739 C6orf192 0.57 6.78 0.35 5.67e-11 Type 2 diabetes nephropathy; CRC cis rs172166 0.543 rs1150691 chr6:28168033 A/G cg15845792 chr6:28175446 NA 0.68 10.11 0.49 4.05e-21 Cardiac Troponin-T levels; CRC cis rs11025559 1.000 rs11025559 chr11:20443875 A/G cg19653624 chr11:20408972 PRMT3 0.61 7.26 0.37 2.75e-12 Pursuit maintenance gain; CRC cis rs9393692 0.557 rs2893820 chr6:26295686 G/A cg13736514 chr6:26305472 NA -0.45 -7.34 -0.38 1.67e-12 Educational attainment; CRC cis rs4665809 0.590 rs4665319 chr2:26424583 A/C cg27170947 chr2:26402098 FAM59B -0.53 -7.15 -0.37 5.7e-12 Gut microbiome composition (summer); CRC cis rs1953600 0.870 rs2573353 chr10:81940917 A/C cg00277334 chr10:82204260 NA -0.36 -5.91 -0.31 8.48e-9 Sarcoidosis; CRC cis rs9522267 0.535 rs2039915 chr13:112238794 C/T cg14352298 chr13:112236639 NA 0.27 6.11 0.32 2.83e-9 Hepatitis; CRC cis rs3845702 0.866 rs3914458 chr2:180862606 A/G cg23417306 chr2:180868811 CWC22 -0.49 -6.72 -0.35 7.82e-11 Schizophrenia; CRC cis rs60780116 1 rs60780116 chr4:185708807 T/C cg01714284 chr4:185714524 ACSL1 -0.55 -5.9 -0.31 9.11e-9 Type 2 diabetes; CRC cis rs801193 0.844 rs2244022 chr7:66202430 A/G cg05627663 chr7:65219948 SNORA22;CCT6P1 0.41 5.93 0.31 7.66e-9 Aortic root size; CRC cis rs2625529 0.652 rs2899776 chr15:72268365 A/T cg16672083 chr15:72433130 SENP8 0.48 7.16 0.37 5.44e-12 Red blood cell count; CRC cis rs1218582 0.774 rs4845679 chr1:154861187 G/T cg03351412 chr1:154909251 PMVK 0.48 7.31 0.37 2.04e-12 Prostate cancer; CRC cis rs6976053 0.935 rs4729620 chr7:100506528 C/A cg10426581 chr7:100472382 SRRT 0.38 5.84 0.31 1.23e-8 Plasminogen activator inhibitor type 1 levels (PAI-1); CRC cis rs13394619 0.935 rs6746291 chr2:11728381 T/C cg07314298 chr2:11723111 GREB1 -0.51 -8.69 -0.43 1.73e-16 Endometriosis; CRC cis rs72781680 0.799 rs2551332 chr2:23988950 T/C cg08917208 chr2:24149416 ATAD2B 0.56 6.45 0.33 4.04e-10 Lymphocyte counts; CRC cis rs826838 0.935 rs1684406 chr12:39127265 A/G cg13010199 chr12:38710504 ALG10B -0.41 -5.84 -0.31 1.27e-8 Heart rate; CRC cis rs875971 0.862 rs10278014 chr7:66051264 C/T cg18252515 chr7:66147081 NA 0.43 6.18 0.32 1.85e-9 Aortic root size; CRC cis rs1018836 0.886 rs12545351 chr8:91636668 C/T cg16814680 chr8:91681699 NA -0.77 -12.37 -0.56 4.04e-29 Ejection fraction in Tripanosoma cruzi seropositivity; CRC cis rs1552244 1.000 rs17032276 chr3:10076975 A/C cg10729496 chr3:10149963 C3orf24 0.55 7.11 0.37 7.07e-12 Alzheimer's disease; CRC cis rs9916302 0.706 rs4332770 chr17:37704712 T/C cg00129232 chr17:37814104 STARD3 -0.59 -7.39 -0.38 1.23e-12 Glomerular filtration rate (creatinine); CRC cis rs3617 0.539 rs11922975 chr3:52936763 C/T cg15147215 chr3:52552868 STAB1 0.45 7.44 0.38 8.85e-13 Red blood cell count;Autism spectrum disorder or schizophrenia; CRC cis rs6545883 0.929 rs2694625 chr2:61616055 G/A cg15711740 chr2:61764176 XPO1 0.46 6.07 0.32 3.59e-9 Tuberculosis; CRC cis rs11758351 0.660 rs75156165 chr6:26235699 C/A cg22723502 chr6:26240528 HIST1H4F -0.37 -5.9 -0.31 9.28e-9 Gout;Renal underexcretion gout; CRC cis rs1129187 1.000 rs1129187 chr6:42932200 G/T cg03790207 chr6:42947109 PEX6 -0.44 -6.14 -0.32 2.43e-9 Alzheimer's disease in APOE e4+ carriers; CRC cis rs7091068 0.518 rs1543580 chr10:95446811 C/T cg20715218 chr10:95462985 C10orf4 0.56 7.54 0.38 4.6e-13 Urinary tract infection frequency; CRC cis rs7224685 0.501 rs781825 chr17:3966064 A/G cg11204139 chr17:3907470 NA 0.74 14.02 0.61 2.4e-35 Type 2 diabetes; CRC cis rs9902453 0.935 rs9909093 chr17:28271207 T/C cg26525008 chr17:28256777 EFCAB5;SSH2 0.7 11.54 0.54 4.14e-26 Coffee consumption (cups per day); CRC cis rs1797081 1.000 rs812426 chr10:16857133 C/G cg23933602 chr10:16859644 RSU1 1.08 22.28 0.78 1.1e-67 Platelet distribution width; CRC cis rs2243480 0.614 rs34032527 chr7:65565141 C/G cg18252515 chr7:66147081 NA -1.14 -13.85 -0.61 1.06e-34 Diabetic kidney disease; CRC cis rs6460942 0.591 rs62448728 chr7:12332915 A/T cg06484146 chr7:12443880 VWDE -0.64 -6.83 -0.35 4.2e-11 Coronary artery disease; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg12012146 chr6:139094629 CCDC28A 0.44 6.17 0.32 2.03e-9 Response to antipsychotic treatment; CRC cis rs58688157 0.705 rs12419720 chr11:598205 C/G cg03909863 chr11:638404 DRD4 -0.53 -7.16 -0.37 5.39e-12 Systemic lupus erythematosus; CRC trans rs9840812 0.953 rs34330586 chr3:135800409 A/T cg17080335 chr12:131030206 NA 0.41 6.25 0.33 1.26e-9 Fibrinogen levels; CRC cis rs9911578 0.967 rs4932693 chr17:57110327 T/C cg05425664 chr17:57184151 TRIM37 0.52 8.22 0.41 4.86e-15 Intelligence (multi-trait analysis); CRC cis rs9311474 0.607 rs4687625 chr3:52563718 C/T cg18404041 chr3:52824283 ITIH1 -0.35 -7.23 -0.37 3.41e-12 Electroencephalogram traits; CRC cis rs7584330 0.666 rs937386 chr2:238364039 C/T cg14458575 chr2:238380390 NA 0.9 16.34 0.67 2.35e-44 Prostate cancer; CRC cis rs7249142 0.562 rs2239370 chr19:19292674 T/C cg26504305 chr19:19281019 LOC729991-MEF2B;MEF2B -0.43 -8.6 -0.43 3.32e-16 IgG glycosylation; CRC cis rs4722166 0.598 rs7804146 chr7:22800929 C/G cg05472934 chr7:22766657 IL6 0.63 10.39 0.5 4.72e-22 Lung cancer; CRC cis rs9549328 0.765 rs1317506 chr13:113631143 C/T cg20742385 chr13:113633654 MCF2L -0.6 -10.46 -0.5 2.62e-22 Systolic blood pressure; CRC cis rs9549260 0.564 rs4943805 chr13:41270080 A/G cg21288729 chr13:41239152 FOXO1 0.42 6.39 0.33 5.65e-10 Red blood cell count; CRC cis rs1387259 0.859 rs2054905 chr12:48687951 A/G cg24011408 chr12:48396354 COL2A1 0.45 6.24 0.33 1.34e-9 Obstructive sleep apnea trait (apnea hypopnea index); CRC cis rs524281 0.861 rs10750779 chr11:65974591 C/G cg16950941 chr11:66035639 RAB1B -0.62 -7.39 -0.38 1.23e-12 Electroencephalogram traits; CRC cis rs897984 0.542 rs750952 chr16:31093954 C/T cg02466173 chr16:30829666 NA -0.59 -9.09 -0.45 9.21e-18 Dementia with Lewy bodies; CRC cis rs6951245 1.000 rs113575110 chr7:1084394 G/A cg18402987 chr7:1209562 NA 0.65 6.84 0.35 3.98e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs68170813 0.562 rs78181351 chr7:106999301 A/G cg02696742 chr7:106810147 HBP1 -0.57 -6.36 -0.33 6.71e-10 Coronary artery disease; CRC cis rs6499255 0.951 rs8045705 chr16:69581672 A/G cg15192750 chr16:69999425 NA 0.56 7.51 0.38 5.69e-13 IgE levels; CRC cis rs7586879 0.551 rs7565460 chr2:25130073 C/T cg22495460 chr2:25135724 ADCY3 -0.87 -17.49 -0.69 6.67e-49 Body mass index; CRC cis rs9457247 0.582 rs9459855 chr6:167466150 G/T cg07741184 chr6:167504864 NA 0.44 7.42 0.38 1.02e-12 Crohn's disease; CRC cis rs12928939 0.815 rs11648483 chr16:71707398 T/C cg08717414 chr16:71523259 ZNF19 -0.46 -5.75 -0.3 2.08e-8 Post bronchodilator FEV1; CRC cis rs1401999 0.668 rs6806313 chr3:183642152 G/C cg05044414 chr3:183734942 ABCC5 0.36 5.94 0.31 7.44e-9 Anterior chamber depth; CRC trans rs10982213 0.830 rs2274163 chr9:117188714 C/T cg06391894 chr10:72142531 LRRC20 0.41 6.06 0.32 3.79e-9 Interleukin-6 levels; CRC cis rs477895 0.713 rs12787852 chr11:63954648 G/A cg04317338 chr11:64019027 PLCB3 0.61 7.41 0.38 1.09e-12 Mean platelet volume; CRC cis rs1707322 0.964 rs10890358 chr1:46319025 T/A cg06784218 chr1:46089804 CCDC17 0.5 8.87 0.44 4.62e-17 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs9549367 0.713 rs2146750 chr13:113822530 A/G cg00898013 chr13:113819073 PROZ 0.53 7.59 0.39 3.26e-13 Platelet distribution width; CRC cis rs3087591 0.639 rs2342053 chr17:29722196 A/G cg24425628 chr17:29625626 OMG;NF1 0.68 12.51 0.57 1.22e-29 Hip circumference; CRC cis rs7647973 0.710 rs6446285 chr3:49626306 G/A cg03060546 chr3:49711283 APEH 0.62 6.36 0.33 6.93e-10 Menarche (age at onset); CRC cis rs2857891 0.817 rs2239730 chr11:6977175 G/C cg04053776 chr11:6947353 ZNF215 0.39 5.71 0.3 2.54e-8 Response to cytadine analogues (cytosine arabinoside); CRC cis rs6963495 0.818 rs73192122 chr7:105171471 G/A cg02135003 chr7:105160482 PUS7 -0.9 -12.08 -0.55 4.87e-28 Bipolar disorder (body mass index interaction); CRC cis rs78456975 0.739 rs28913003 chr2:1519620 A/T cg26248373 chr2:1572462 NA -0.64 -8.09 -0.41 1.16e-14 Placebo response in major depressive disorder (% change in symptom score); CRC cis rs4665809 0.531 rs10199898 chr2:26445485 T/G cg22920501 chr2:26401640 FAM59B -0.83 -11.96 -0.55 1.28e-27 Gut microbiome composition (summer); CRC cis rs1712517 0.771 rs11191654 chr10:105077124 C/A cg05636881 chr10:105038444 INA 0.44 7.78 0.39 9.32e-14 Migraine; CRC cis rs546131 0.928 rs499183 chr11:34836678 A/G cg11058730 chr11:34937778 PDHX;APIP 0.46 6.81 0.35 4.6e-11 Lung disease severity in cystic fibrosis; CRC cis rs9911578 0.935 rs117819974 chr17:57002324 C/T cg05425664 chr17:57184151 TRIM37 -0.49 -7.66 -0.39 2.14e-13 Intelligence (multi-trait analysis); CRC cis rs2120019 0.938 rs3850093 chr15:75318482 A/G cg11632617 chr15:75315747 PPCDC 0.55 6.96 0.36 1.82e-11 Blood trace element (Zn levels); CRC cis rs12497850 0.864 rs7431857 chr3:48900347 G/A cg20833759 chr3:49053208 WDR6;DALRD3 0.53 9.22 0.45 3.73e-18 Parkinson's disease; CRC cis rs9527 0.637 rs7085104 chr10:104628873 A/G cg08772003 chr10:104629869 AS3MT -0.41 -6.89 -0.36 2.86e-11 Arsenic metabolism; CRC cis rs270601 0.770 rs1007602 chr5:131602166 T/C cg20512303 chr5:131592959 PDLIM4 0.4 7.55 0.38 4.36e-13 Acylcarnitine levels; CRC cis rs6496044 0.548 rs7163032 chr15:86072419 T/A cg17133734 chr15:86042851 AKAP13 0.39 6.34 0.33 7.48e-10 Interstitial lung disease; CRC cis rs798766 1.000 rs11729657 chr4:1737585 T/C cg02089348 chr4:1724449 TMEM129;TACC3 -0.4 -5.78 -0.3 1.77e-8 Bladder cancer;Urinary bladder cancer; CRC trans rs3780486 0.846 rs3780490 chr9:33129839 A/G cg20290983 chr6:43655470 MRPS18A 1.16 27.12 0.83 6.77e-86 IgG glycosylation; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg06404838 chr11:117015391 PAFAH1B2 0.46 6.35 0.33 7.33e-10 Response to antipsychotic treatment; CRC cis rs561341 0.710 rs9900031 chr17:30199537 T/C cg00745463 chr17:30367425 LRRC37B 0.6 6.92 0.36 2.42e-11 Hip circumference adjusted for BMI; CRC cis rs10504073 0.669 rs62507253 chr8:50028836 C/T cg00325661 chr8:49890786 NA 0.53 9.51 0.46 4.25e-19 Blood metabolite ratios; CRC cis rs13118159 0.509 rs10023473 chr4:1375285 C/T cg05025164 chr4:1340916 KIAA1530 0.52 7.49 0.38 6.2800000000000005e-13 Longevity; CRC cis rs875971 0.862 rs57866200 chr7:65565392 A/G cg18252515 chr7:66147081 NA 0.4 5.9 0.31 9.26e-9 Aortic root size; CRC trans rs7618501 0.966 rs13085679 chr3:49869631 G/A cg21665057 chr3:196295764 WDR53;FBXO45 0.85 15.28 0.64 3.22e-40 Intelligence (multi-trait analysis); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg18280492 chr10:124913593 BUB3 0.44 6.08 0.32 3.41e-9 Response to antipsychotic treatment; CRC cis rs7537052 0.646 rs6680302 chr1:36653540 C/T cg24686825 chr1:36642396 MAP7D1 -0.61 -8.85 -0.44 5.52e-17 Schizophrenia; CRC cis rs7937682 0.855 rs539553 chr11:111477333 C/T cg19812747 chr11:111475976 SIK2 -0.6 -10.32 -0.49 8.4e-22 Primary sclerosing cholangitis; CRC trans rs61931739 0.500 rs4436630 chr12:34394200 C/T cg13010199 chr12:38710504 ALG10B 0.44 6.33 0.33 8.16e-10 Morning vs. evening chronotype; CRC cis rs3771570 0.901 rs3815262 chr2:242352582 A/T cg21155796 chr2:242212141 HDLBP 0.56 6.8 0.35 4.93e-11 Prostate cancer; CRC cis rs17711722 0.740 rs7809991 chr7:65406218 A/G cg00343986 chr7:65444356 GUSB 0.57 8.64 0.43 2.56e-16 Calcium levels; CRC cis rs1799949 1.000 rs12952790 chr17:41299607 A/G cg01879757 chr17:41196368 BRCA1 -0.44 -6.67 -0.35 1.06e-10 Menopause (age at onset); CRC cis rs644799 1.000 rs473148 chr11:95628606 A/G cg25478527 chr11:95522999 CEP57;FAM76B 0.5 7.39 0.38 1.21e-12 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs72781680 1.000 rs72796351 chr2:24158425 T/C cg08917208 chr2:24149416 ATAD2B 0.93 9.46 0.46 6.18e-19 Lymphocyte counts; CRC trans rs9858542 0.903 rs35999162 chr3:49597230 C/G cg21665057 chr3:196295764 WDR53;FBXO45 -0.66 -8.91 -0.44 3.47e-17 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC trans rs17270561 0.583 rs7765833 chr6:25712433 C/A cg17050643 chr15:85144610 ZSCAN2 0.41 6.04 0.32 4.28e-9 Iron status biomarkers; CRC cis rs875971 0.862 rs801203 chr7:66023012 A/G cg00343986 chr7:65444356 GUSB -0.44 -6.16 -0.32 2.16e-9 Aortic root size; CRC cis rs9372498 0.536 rs62424175 chr6:118797381 T/A cg22561889 chr6:118971681 C6orf204 0.48 6.03 0.32 4.35e-9 Diastolic blood pressure; CRC cis rs7626444 0.625 rs2669637 chr3:196477369 G/A cg12930392 chr3:196481615 PAK2 0.4 7.26 0.37 2.73e-12 Monocyte count; CRC cis rs1878931 0.582 rs27232 chr16:3436782 G/A cg26668626 chr16:3451006 ZNF174;ZNF434 -0.55 -6.65 -0.34 1.24e-10 Body mass index (adult); CRC cis rs11098499 0.754 rs17049949 chr4:120255290 A/G cg24375607 chr4:120327624 NA 0.47 7.45 0.38 8.16e-13 Corneal astigmatism; CRC cis rs9296404 1 rs9296404 chr6:42925803 T/C cg05552183 chr6:42928497 GNMT 0.52 7.93 0.4 3.49e-14 Plasma homocysteine levels (post-methionine load test); CRC cis rs11764590 0.715 rs9639202 chr7:2087315 G/A cg23378565 chr7:2036160 MAD1L1 -0.41 -5.69 -0.3 2.74e-8 Neuroticism; CRC cis rs8078723 0.714 rs3859187 chr17:38150613 C/A cg17344932 chr17:38183730 MED24;SNORD124 0.48 7.98 0.4 2.4e-14 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); CRC cis rs3771570 1.000 rs56363214 chr2:242227157 A/G cg21155796 chr2:242212141 HDLBP 0.64 7.0 0.36 1.48e-11 Prostate cancer; CRC cis rs11997175 0.646 rs66856932 chr8:33700782 A/G ch.8.33884649F chr8:33765107 NA 0.46 6.62 0.34 1.45e-10 Body mass index; CRC cis rs12900413 0.687 rs12908468 chr15:90304236 T/G cg24249390 chr15:90295951 MESP1 -0.56 -8.74 -0.43 1.19e-16 Coronary artery aneurysm in Kawasaki disease; CRC cis rs7119 0.717 rs11634174 chr15:77811232 A/T cg27398640 chr15:77910606 LINGO1 -0.44 -7.9 -0.4 4.22e-14 Type 2 diabetes; CRC cis rs4423214 0.802 rs2276358 chr11:71184498 G/A cg13043300 chr11:71146211 DHCR7 -0.44 -5.98 -0.31 5.98e-9 Vitamin D levels; CRC cis rs7973719 0.865 rs12228393 chr12:7368182 A/G cg07052231 chr12:7363540 PEX5 -0.56 -9.32 -0.46 1.71e-18 IgG glycosylation; CRC cis rs16852403 0.619 rs10047059 chr1:178142196 A/C cg00404053 chr1:178313656 RASAL2 -0.56 -6.88 -0.35 3.11e-11 Childhood ear infection; CRC trans rs2288327 0.643 rs1559908 chr2:179336347 C/T cg14011486 chr1:26737247 LIN28 -0.43 -6.27 -0.33 1.13e-9 Atrial fibrillation; CRC cis rs8062405 1.000 rs62036616 chr16:28826307 A/G cg16576597 chr16:28551801 NUPR1 0.42 5.82 0.31 1.36e-8 Cognitive ability (multi-trait analysis);Cognitive ability; CRC cis rs13118159 0.742 rs7679860 chr4:1333987 C/T cg21620606 chr4:1342894 KIAA1530 0.5 8.56 0.43 4.35e-16 Longevity; CRC cis rs9818758 0.607 rs11552724 chr3:49156473 C/G cg07636037 chr3:49044803 WDR6 -0.75 -6.21 -0.32 1.63e-9 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; CRC trans rs7142881 0.629 rs8018532 chr14:32296156 G/A cg07250515 chr12:56618133 OBFC2B 0.39 5.97 0.31 6.15e-9 Response to iloperidone treatment (QT prolongation); CRC cis rs2739330 0.828 rs2877178 chr22:24251517 C/T cg16132339 chr22:24313637 DDTL;DDT 0.64 10.19 0.49 2.27e-21 Liver enzyme levels (gamma-glutamyl transferase); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg07147234 chr12:56522077 ESYT1 0.47 6.6 0.34 1.68e-10 Response to antipsychotic treatment; CRC cis rs6964587 0.626 rs7807765 chr7:91531974 C/A cg17063962 chr7:91808500 NA -0.58 -9.16 -0.45 5.76e-18 Breast cancer; CRC cis rs7527798 0.592 rs12144801 chr1:207857773 A/G cg09232269 chr1:207846808 CR1L -0.45 -7.33 -0.37 1.84e-12 Erythrocyte sedimentation rate; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg23040205 chr20:23331342 NXT1 0.42 6.0 0.31 5.14e-9 Anxiety disorder; CRC cis rs9914988 0.943 rs4795457 chr17:27087929 C/T cg12682573 chr17:27188876 MIR451;MIR144 0.58 7.78 0.39 9.6e-14 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs17209837 0.607 rs2270187 chr7:87080698 T/C cg00919237 chr7:87102261 ABCB4 -0.53 -7.1 -0.36 7.54e-12 Gallbladder cancer; CRC cis rs6743376 0.556 rs2472188 chr2:113820814 C/G cg24553058 chr2:113831203 IL1F10 0.44 7.18 0.37 4.61e-12 Inflammatory biomarkers; CRC cis rs7914558 0.933 rs12763665 chr10:104653717 G/A cg04362960 chr10:104952993 NT5C2 0.59 8.93 0.44 3.13e-17 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs34779708 0.931 rs12767414 chr10:35390193 C/T cg03585969 chr10:35415529 CREM 0.57 7.76 0.39 1.06e-13 Inflammatory bowel disease;Crohn's disease; CRC cis rs8067545 0.641 rs203458 chr17:19816898 A/C cg04132472 chr17:19861366 AKAP10 0.43 6.72 0.35 7.87e-11 Schizophrenia; CRC cis rs9329289 0.510 rs35854428 chr10:2554280 T/C cg15501526 chr10:2543763 NA 0.48 8.92 0.44 3.38e-17 Age-related hearing impairment; CRC cis rs910316 1.000 rs1047418 chr14:75605792 A/G cg11812906 chr14:75593930 NEK9 0.59 9.31 0.46 1.9e-18 Height; CRC cis rs7737355 0.947 rs9327620 chr5:130996451 A/G cg06307176 chr5:131281290 NA 0.41 5.89 0.31 9.38e-9 Life satisfaction; CRC cis rs1348850 0.872 rs7559521 chr2:178452328 A/G cg22681709 chr2:178499509 PDE11A 0.35 6.47 0.34 3.6e-10 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs992157 0.764 rs4552182 chr2:219184872 G/T cg04880052 chr2:219191631 PNKD 0.4 6.1 0.32 3.01e-9 Colorectal cancer; CRC cis rs2710642 0.821 rs56373728 chr2:63095792 G/A cg17519650 chr2:63277830 OTX1 0.44 6.37 0.33 6.46e-10 LDL cholesterol levels;LDL cholesterol; CRC cis rs7224685 0.608 rs17763551 chr17:3882309 C/T cg11204139 chr17:3907470 NA 0.46 5.75 0.3 2.05e-8 Type 2 diabetes; CRC cis rs891088 0.677 rs17253937 chr19:7184801 C/T cg00428638 chr19:7224713 INSR -0.56 -6.07 -0.32 3.54e-9 Hip circumference adjusted for BMI;Height; CRC cis rs55665837 0.922 rs12287212 chr11:14449861 C/A cg19336497 chr11:14380999 RRAS2 -0.4 -6.83 -0.35 4.13e-11 Vitamin D levels; CRC cis rs6499255 0.951 rs1437135 chr16:69757828 A/G cg15192750 chr16:69999425 NA 0.54 7.1 0.36 7.55e-12 IgE levels; CRC cis rs2836974 0.796 rs77153312 chr21:40695499 G/A cg11644478 chr21:40555479 PSMG1 0.75 10.81 0.51 1.7e-23 Cognitive function; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg12651014 chr10:32735292 CCDC7 -0.45 -6.59 -0.34 1.72e-10 Myopia (pathological); CRC cis rs34779708 0.966 rs17499811 chr10:35456215 G/A cg03585969 chr10:35415529 CREM 0.66 8.75 0.43 1.14e-16 Inflammatory bowel disease;Crohn's disease; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg02755475 chr16:67927351 PSKH1 0.46 6.11 0.32 2.88e-9 Anxiety disorder; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg25403298 chr7:129251373 NRF1 0.46 6.85 0.35 3.53e-11 Intelligence (multi-trait analysis); CRC cis rs1552244 0.882 rs3846168 chr3:9996925 C/T cg02579736 chr3:10068473 FANCD2;CIDECP 0.91 11.88 0.55 2.43e-27 Alzheimer's disease; CRC cis rs4713118 0.869 rs9283883 chr6:27715470 T/A cg15845792 chr6:28175446 NA 0.66 9.05 0.45 1.3e-17 Parkinson's disease; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg00747290 chr2:42721154 KCNG3 0.35 6.54 0.34 2.31e-10 Liver disease severity in Alagille syndrome; CRC cis rs7552404 0.731 rs1770885 chr1:76402212 C/T cg22875332 chr1:76189707 ACADM -0.47 -5.9 -0.31 9.03e-9 Blood metabolite levels;Acylcarnitine levels; CRC cis rs4716602 0.596 rs10949585 chr7:156165258 A/C cg16983916 chr7:156159713 NA -0.38 -6.65 -0.34 1.25e-10 Anti-saccade response; CRC cis rs10504229 0.815 rs17805008 chr8:58160185 G/T cg02725872 chr8:58115012 NA -0.58 -9.07 -0.45 1.07e-17 Developmental language disorder (linguistic errors); CRC cis rs9911578 1.000 rs304299 chr17:56838472 C/G cg05425664 chr17:57184151 TRIM37 -0.48 -7.51 -0.38 5.54e-13 Intelligence (multi-trait analysis); CRC cis rs1707322 1.000 rs10890370 chr1:46389217 C/T cg06784218 chr1:46089804 CCDC17 0.5 8.5 0.42 6.72e-16 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs4664308 0.935 rs4520993 chr2:160937673 G/A cg03641300 chr2:160917029 PLA2R1 -0.73 -11.66 -0.54 1.59e-26 Idiopathic membranous nephropathy; CRC cis rs597583 1.000 rs521609 chr11:117407301 C/T cg27161313 chr11:117392002 DSCAML1 -0.38 -5.62 -0.3 4.05e-8 Putamen volume; CRC cis rs6088580 0.634 rs2184836 chr20:32963369 A/G cg08999081 chr20:33150536 PIGU -0.6 -11.21 -0.53 6.38e-25 Glomerular filtration rate (creatinine); CRC trans rs10983614 1.000 rs7867776 chr9:120072627 A/G cg14094063 chr7:140624470 BRAF 0.6 8.47 0.42 8.13e-16 Survival in pancreatic cancer; CRC cis rs860295 0.702 rs11264375 chr1:155424065 C/T cg02153340 chr1:155202674 NA 0.48 5.95 0.31 7e-9 Body mass index; CRC cis rs2243480 1.000 rs160643 chr7:65558222 C/T cg12463550 chr7:65579703 CRCP 0.55 5.64 0.3 3.62e-8 Diabetic kidney disease; CRC cis rs10256972 0.713 rs10435026 chr7:1065948 A/G cg02869364 chr7:1081709 C7orf50 -0.4 -6.05 -0.32 3.92e-9 Longevity;Endometriosis; CRC trans rs1455244 0.700 rs7229302 chr18:11508904 G/T cg21054179 chr12:49412581 PRKAG1 0.39 6.27 0.33 1.14e-9 Schizophrenia; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg24488506 chr11:65667952 FOSL1 0.4 6.13 0.32 2.55e-9 Liver disease severity in Alagille syndrome; CRC cis rs2976388 0.507 rs13259549 chr8:143838519 T/C cg22687807 chr8:143858763 LYNX1 0.61 10.84 0.51 1.34e-23 Urinary tract infection frequency; CRC cis rs9891119 0.602 rs9895473 chr17:40515722 G/A cg06270615 chr17:40516068 STAT3 -0.34 -7.17 -0.37 4.87e-12 Multiple sclerosis;Crohn's disease; CRC cis rs1799949 0.965 rs1842147 chr17:41435192 C/T cg25072359 chr17:41440525 NA 0.42 6.14 0.32 2.38e-9 Menopause (age at onset); CRC cis rs853679 0.517 rs17711801 chr6:28092307 C/G cg03623178 chr6:28175578 NA 0.96 12.57 0.57 7.23e-30 Depression; CRC cis rs16975963 0.644 rs73033145 chr19:38097313 T/G cg15135657 chr19:38346511 NA -0.46 -6.32 -0.33 8.35e-10 Longevity; CRC cis rs4713118 0.527 rs36042294 chr6:27720712 C/G cg25164649 chr6:28176230 NA 0.54 7.8 0.4 8.18e-14 Parkinson's disease; CRC cis rs9296092 0.517 rs56043172 chr6:33522363 T/G cg13560919 chr6:33536144 NA -0.43 -6.17 -0.32 2.04e-9 Age at smoking initiation in chronic obstructive pulmonary disease; CRC cis rs769267 0.896 rs10405625 chr19:19579046 T/G cg03709012 chr19:19516395 GATAD2A 0.72 11.24 0.53 4.97e-25 Tonsillectomy; CRC cis rs17666538 0.585 rs1669733 chr8:606696 C/T cg07234876 chr8:600039 NA -0.78 -7.07 -0.36 9.24e-12 IgG glycosylation; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg09463466 chr15:77925892 LINGO1 -0.4 -6.09 -0.32 3.16e-9 Myopia (pathological); CRC cis rs763121 1.000 rs763121 chr22:38879940 C/T cg06022373 chr22:39101656 GTPBP1 -0.64 -9.15 -0.45 6.3e-18 Menopause (age at onset); CRC cis rs35110281 0.693 rs11089093 chr21:45121161 C/T cg04455712 chr21:45112962 RRP1B 0.41 7.97 0.4 2.55e-14 Mean corpuscular volume; CRC cis rs9443189 0.570 rs72884926 chr6:76266208 T/C cg01950844 chr6:76311363 SENP6 0.71 9.25 0.45 2.99e-18 Prostate cancer; CRC cis rs477895 0.838 rs12794145 chr11:64006484 C/T cg18375707 chr11:64034959 PLCB3 0.45 6.25 0.33 1.3e-9 Mean platelet volume; CRC cis rs12044355 0.929 rs6693517 chr1:231852444 G/A cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX 0.45 6.06 0.32 3.72e-9 Alzheimer's disease; CRC cis rs6831352 1.000 rs6831352 chr4:100063525 T/C cg13256891 chr4:100009986 ADH5 0.61 8.58 0.43 3.82e-16 Alcohol dependence; CRC cis rs2032447 0.839 rs6901039 chr6:26000885 A/C cg04800585 chr6:26043546 HIST1H2BB 0.54 8.2 0.41 5.37e-15 Intelligence (multi-trait analysis); CRC cis rs780096 0.565 rs813592 chr2:27721971 T/C cg02592271 chr2:27665507 KRTCAP3 -0.25 -5.86 -0.31 1.15e-8 Total body bone mineral density; CRC cis rs3749237 0.595 rs11720264 chr3:49580347 C/T cg07636037 chr3:49044803 WDR6 0.55 8.05 0.41 1.48e-14 Resting heart rate; CRC trans rs1367248 0.943 rs780043 chr2:125007352 C/G cg07402188 chr19:40720005 MAP3K10 -0.45 -6.16 -0.32 2.1e-9 Tonometry; CRC cis rs4665809 0.531 rs12990692 chr2:26464939 C/T cg26119090 chr2:26468346 HADHA;HADHB 1.0 14.65 0.63 8.89e-38 Gut microbiome composition (summer); CRC cis rs7119 0.604 rs2682924 chr15:77863720 C/T cg10437265 chr15:77819839 NA 0.52 8.81 0.44 7.34e-17 Type 2 diabetes; CRC cis rs2836950 0.520 rs8133927 chr21:40689961 G/T cg11890956 chr21:40555474 PSMG1 -0.61 -8.99 -0.44 1.95e-17 Menarche (age at onset); CRC cis rs6460942 0.915 rs17541464 chr7:12462675 A/G cg20607287 chr7:12443886 VWDE -0.59 -7.3 -0.37 2.12e-12 Coronary artery disease; CRC cis rs17270561 0.609 rs7770037 chr6:25760591 G/A cg17691542 chr6:26056736 HIST1H1C 0.64 8.14 0.41 8.02e-15 Iron status biomarkers; CRC cis rs3741404 0.620 rs2236648 chr11:63964657 C/T cg06219103 chr11:63990595 FERMT3 -0.44 -6.92 -0.36 2.36e-11 Platelet count; CRC cis rs9300255 0.602 rs1616181 chr12:123619856 T/A cg00376283 chr12:123451042 ABCB9 0.6 8.15 0.41 7.58e-15 Neutrophil percentage of white cells; CRC trans rs7819412 0.745 rs6601569 chr8:11073578 C/T cg16141378 chr3:129829833 LOC729375 0.43 6.14 0.32 2.43e-9 Triglycerides; CRC cis rs10486722 0.606 rs10951661 chr7:41810755 A/G cg22138096 chr7:41772439 LOC285954 0.45 6.01 0.31 4.95e-9 Pit-and-Fissure caries; CRC cis rs6952808 0.543 rs4719436 chr7:2141239 G/A cg22963979 chr7:1858916 MAD1L1 -0.46 -6.59 -0.34 1.74e-10 Bipolar disorder and schizophrenia; CRC cis rs9322193 0.923 rs12176034 chr6:150121693 C/T cg00933542 chr6:150070202 PCMT1 0.31 5.95 0.31 7.03e-9 Lung cancer; CRC cis rs13108904 0.935 rs6853002 chr4:1295991 C/T cg15763984 chr4:1342303 KIAA1530 0.33 5.67 0.3 3.15e-8 Obesity-related traits; CRC cis rs533581 0.866 rs865102 chr16:88969969 A/G cg09141835 chr16:88988174 CBFA2T3 -0.27 -6.07 -0.32 3.52e-9 Social autistic-like traits; CRC cis rs9649213 0.555 rs6956686 chr7:97997945 T/C cg24562669 chr7:97807699 LMTK2 0.43 7.16 0.37 5.21e-12 Prostate cancer (SNP x SNP interaction); CRC cis rs892961 0.932 rs7223768 chr17:75410521 G/A cg05865280 chr17:75406074 SEPT9 0.62 14.02 0.61 2.42e-35 Airflow obstruction; CRC cis rs144345632 1 rs144345632 chr6:96886894 T/TA cg06623918 chr6:96969491 KIAA0776 -0.81 -9.51 -0.46 4.17e-19 Facial morphology (factor 17, height of vermillion upper lip); CRC cis rs9517320 0.534 rs3858778 chr13:99172249 A/C cg20487152 chr13:99095054 FARP1 0.43 6.37 0.33 6.46e-10 Longevity; CRC cis rs9611565 0.559 rs4822048 chr22:41988225 C/T cg06634786 chr22:41940651 POLR3H -0.62 -6.38 -0.33 6.07e-10 Vitiligo; CRC cis rs9814567 1.000 rs9826496 chr3:134224437 G/C cg06109529 chr3:134205091 CEP63;ANAPC13 -0.81 -12.23 -0.56 1.31e-28 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg15350925 chr8:86132775 C8orf59 0.4 5.98 0.31 5.85e-9 Liver disease severity in Alagille syndrome; CRC cis rs11190604 1.000 rs10883511 chr10:102299407 A/G cg16342193 chr10:102329863 NA -0.35 -5.84 -0.31 1.25e-8 Palmitoleic acid (16:1n-7) levels; CRC cis rs7258465 0.931 rs8107347 chr19:18612748 G/A cg10790698 chr19:18539756 SSBP4 -0.43 -8.4 -0.42 1.37e-15 Breast cancer; CRC cis rs13315871 0.929 rs77178267 chr3:58320657 T/G cg20936604 chr3:58311152 NA -0.76 -7.25 -0.37 2.99e-12 Cholesterol, total; CRC cis rs9486719 1.000 rs3798295 chr6:97052164 C/T cg06623918 chr6:96969491 KIAA0776 -0.82 -9.48 -0.46 5.37e-19 Migraine;Coronary artery disease; CRC cis rs798554 0.524 rs2283784 chr7:2855337 T/C cg04166393 chr7:2884313 GNA12 0.4 6.1 0.32 3.02e-9 Height; CRC cis rs10871290 0.801 rs3851726 chr16:74471644 G/C cg01733217 chr16:74700730 RFWD3 -0.72 -11.58 -0.54 2.94e-26 Breast cancer; CRC cis rs4713118 0.629 rs203888 chr6:28021589 C/T cg06470822 chr6:28175283 NA 0.89 13.43 0.59 4.47e-33 Parkinson's disease; CRC cis rs1712517 0.771 rs10883858 chr10:105127708 G/A cg05636881 chr10:105038444 INA 0.46 8.07 0.41 1.3e-14 Migraine; CRC cis rs35306767 0.761 rs11253537 chr10:1010735 G/A cg20503657 chr10:835505 NA 0.91 10.86 0.51 1.08e-23 Eosinophil percentage of granulocytes; CRC cis rs6831352 0.918 rs7689753 chr4:100055575 A/G cg13256891 chr4:100009986 ADH5 -0.66 -8.89 -0.44 4.04e-17 Alcohol dependence; CRC cis rs8180040 0.726 rs61729713 chr3:47027192 A/G cg02527881 chr3:46936655 PTH1R 0.37 6.76 0.35 6.12e-11 Colorectal cancer; CRC cis rs4555082 0.874 rs760270 chr14:105737785 A/G cg13114125 chr14:105738426 BRF1 -0.8 -11.63 -0.54 2.08e-26 Mean platelet volume;Platelet distribution width; CRC cis rs7917772 0.503 rs6584510 chr10:104299868 T/G cg11453585 chr10:104263688 ACTR1A;SUFU 0.9 16.75 0.68 5.87e-46 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC cis rs2576037 0.623 rs2576042 chr18:44577461 T/C cg19077165 chr18:44547161 KATNAL2 0.65 10.53 0.5 1.52e-22 Personality dimensions; CRC cis rs3733585 0.534 rs7375642 chr4:9955236 A/G cg00071950 chr4:10020882 SLC2A9 -0.55 -9.78 -0.47 5.18e-20 Cleft plate (environmental tobacco smoke interaction); CRC cis rs798554 0.610 rs1182209 chr7:2808595 C/T cg17321639 chr7:2759063 NA -0.38 -5.63 -0.3 3.89e-8 Height; CRC cis rs789859 1.000 rs789860 chr3:194405630 A/T cg21106136 chr3:194405973 FAM43A -0.45 -6.53 -0.34 2.43e-10 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; CRC cis rs10504229 0.775 rs10504228 chr8:58162053 T/G cg02290350 chr8:58132656 NA -0.5 -6.22 -0.32 1.5e-9 Developmental language disorder (linguistic errors); CRC trans rs2303319 0.504 rs62187609 chr2:162431500 C/T cg04269497 chr6:167369491 RNASET2 -0.75 -5.99 -0.31 5.54e-9 Cognitive function; CRC cis rs7408868 0.563 rs10423702 chr19:15300069 T/C cg14696996 chr19:15285081 NOTCH3 0.75 7.81 0.4 7.81e-14 Pulse pressure; CRC cis rs4523957 0.928 rs8065650 chr17:2180823 A/G cg16513277 chr17:2031491 SMG6 0.54 9.02 0.45 1.63e-17 Autism spectrum disorder or schizophrenia;Schizophrenia; CRC cis rs7786808 0.712 rs2335167 chr7:158213948 A/C cg15440763 chr7:158190612 PTPRN2 0.53 8.64 0.43 2.49e-16 Obesity-related traits; CRC cis rs7726839 0.794 rs6883536 chr5:599274 G/A cg09021430 chr5:549028 NA -0.62 -8.36 -0.42 1.76e-15 Obesity-related traits; CRC cis rs4843747 0.749 rs13333619 chr16:88072076 C/T cg17633681 chr16:88106987 BANP 0.81 13.72 0.6 3.35e-34 Menopause (age at onset); CRC cis rs6860806 0.661 rs1588263 chr5:131577158 T/C cg04518342 chr5:131593106 PDLIM4 0.47 8.77 0.44 1.01e-16 Breast cancer; CRC cis rs9488822 0.676 rs4354188 chr6:116327936 T/C cg18764771 chr6:116381957 FRK 0.25 7.0 0.36 1.42e-11 Cholesterol, total;LDL cholesterol; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg14049382 chr22:50781530 SAPS2 0.5 7.07 0.36 9.48e-12 Response to antipsychotic treatment; CRC cis rs2562152 0.786 rs216594 chr16:103009 A/T cg02949481 chr16:131562 MPG 0.58 6.66 0.34 1.18e-10 Glioblastoma; CRC cis rs10971721 0.818 rs10971708 chr9:33803271 T/A cg13495928 chr9:33750294 PRSS3 0.6 5.76 0.3 1.91e-8 Body mass index; CRC cis rs9916302 0.706 rs9891892 chr17:37479856 A/C cg07936489 chr17:37558343 FBXL20 0.9 11.59 0.54 2.74e-26 Glomerular filtration rate (creatinine); CRC cis rs7274811 0.625 rs293722 chr20:31927361 C/T cg21523528 chr20:32077966 CBFA2T2 0.43 6.11 0.32 2.86e-9 Height; CRC cis rs9614461 0.609 rs9614653 chr22:45767391 A/G cg15911859 chr22:45810043 RIBC2;SMC1B -0.62 -6.75 -0.35 6.77e-11 Tonsillectomy; CRC cis rs1348850 0.914 rs10170546 chr2:178248790 C/T cg22681709 chr2:178499509 PDE11A -0.37 -6.88 -0.35 3.03e-11 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs773506 0.655 rs10991796 chr9:93930243 G/T cg14446406 chr9:93919335 NA -0.45 -7.75 -0.39 1.16e-13 Type 2 diabetes nephropathy; CRC cis rs4253772 0.591 rs6008361 chr22:46652372 A/G cg24881330 chr22:46731750 TRMU -0.57 -6.87 -0.35 3.26e-11 LDL cholesterol;Cholesterol, total; CRC cis rs7666738 0.830 rs60411337 chr4:99046617 T/C cg05340658 chr4:99064831 C4orf37 0.6 9.35 0.46 1.37e-18 Colonoscopy-negative controls vs population controls; CRC cis rs6460942 0.915 rs62448598 chr7:12453762 T/C cg20607287 chr7:12443886 VWDE -0.66 -6.93 -0.36 2.17e-11 Coronary artery disease; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg24420395 chr8:29206910 DUSP4 0.48 6.95 0.36 1.91e-11 Response to antipsychotic treatment; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg08891424 chr2:190648631 ORMDL1;PMS1 0.47 6.04 0.32 4.14e-9 Thyroid stimulating hormone; CRC cis rs6534441 0.857 rs9993116 chr4:125459632 G/A cg21609808 chr4:125404261 NA 0.38 5.75 0.3 2.07e-8 Major depressive disorder; CRC cis rs4409675 0.576 rs6691656 chr1:28221130 C/G cg23691781 chr1:28212827 C1orf38 0.33 7.83 0.4 6.58e-14 Corneal astigmatism; CRC cis rs35520189 0.591 rs11696039 chr2:113698078 A/G cg12858261 chr2:113808755 IL1F8 0.51 7.05 0.36 1.04e-11 Obstructive sleep apnea trait (apnea hypopnea index); CRC cis rs9921222 1.000 rs9921222 chr16:375782 A/G cg12437481 chr16:420112 MRPL28 0.56 8.29 0.42 2.91e-15 Bone mineral density (spine);Bone mineral density; CRC cis rs2762353 0.779 rs6905614 chr6:25840485 G/T cg03264133 chr6:25882463 NA -0.45 -6.88 -0.35 3.12e-11 Blood metabolite levels; CRC cis rs2307022 0.586 rs10852441 chr16:68385439 T/A cg02226672 chr16:68398533 SMPD3 0.28 5.62 0.3 4.04e-8 Body mass index; CRC cis rs7713065 0.531 rs2522051 chr5:131797578 C/T cg09877947 chr5:131593287 PDLIM4 0.34 6.07 0.32 3.47e-9 Lung function (FEV1/FVC); CRC cis rs651907 0.557 rs3864012 chr3:101397623 T/C cg11279151 chr3:101281821 RG9MTD1 -0.5 -6.87 -0.35 3.12e-11 Colorectal cancer; CRC cis rs6502050 0.835 rs3935129 chr17:80113381 G/C cg19223190 chr17:80058835 NA 0.4 6.36 0.33 6.88e-10 Life satisfaction; CRC trans rs58688157 0.705 rs12421646 chr11:578844 C/G cg19188899 chr13:112838565 NA -0.41 -6.32 -0.33 8.27e-10 Systemic lupus erythematosus; CRC trans rs7267979 1.000 rs4815421 chr20:25386509 G/A cg17903999 chr18:56338584 MALT1 0.42 6.93 0.36 2.17e-11 Liver enzyme levels (alkaline phosphatase); CRC cis rs868943 0.714 rs13193683 chr6:116356235 A/T cg05304507 chr6:116381966 FRK 0.29 6.35 0.33 7.1e-10 Total cholesterol levels; CRC cis rs7666738 0.830 rs13124127 chr4:98990729 G/A cg17366294 chr4:99064904 C4orf37 0.43 7.15 0.37 5.68e-12 Colonoscopy-negative controls vs population controls; CRC trans rs10863936 0.558 rs7522330 chr1:212234104 A/T cg19386303 chr19:47104863 CALM3 -0.42 -6.19 -0.32 1.76e-9 Height; CRC cis rs6502050 0.835 rs9898697 chr17:80100498 A/G cg19223190 chr17:80058835 NA 0.4 6.33 0.33 7.89e-10 Life satisfaction; CRC cis rs10256972 0.591 rs11766651 chr7:1161646 A/G cg07308232 chr7:1071921 C7orf50 -0.49 -6.69 -0.35 9.86e-11 Longevity;Endometriosis; CRC cis rs72945132 0.556 rs57172967 chr11:70160060 G/A cg00319359 chr11:70116639 PPFIA1 0.68 7.51 0.38 5.61e-13 Coronary artery disease; CRC cis rs11711311 1.000 rs2566970 chr3:113462123 A/G cg06805542 chr3:113465803 ATP6V1A;NAA50 0.53 7.27 0.37 2.56e-12 IgG glycosylation; CRC cis rs25422 0.938 rs9489443 chr6:118886163 T/A cg15382696 chr6:118971807 C6orf204 0.61 7.9 0.4 4.29e-14 Renal cell carcinoma; CRC cis rs6502050 0.799 rs6502089 chr17:80169523 G/A cg13198984 chr17:80129470 CCDC57 0.44 7.63 0.39 2.51e-13 Life satisfaction; CRC cis rs8105895 0.935 rs6511316 chr19:22237629 T/C cg02657401 chr19:22469223 NA -0.34 -5.65 -0.3 3.56e-8 Body mass index (change over time); CRC cis rs1008375 1.000 rs3815413 chr4:17654648 T/C cg16339924 chr4:17578868 LAP3 0.55 7.3 0.37 2.13e-12 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs9467711 0.659 rs35277236 chr6:26562269 G/T cg12315302 chr6:26189340 HIST1H4D 0.99 6.93 0.36 2.22e-11 Autism spectrum disorder or schizophrenia; CRC cis rs6502050 0.799 rs34795957 chr17:80118013 G/A cg11859384 chr17:80120422 CCDC57 -0.37 -5.9 -0.31 8.99e-9 Life satisfaction; CRC cis rs6976053 0.518 rs314353 chr7:100406144 A/G cg20848291 chr7:100343083 ZAN 0.39 5.94 0.31 7.15e-9 Plasminogen activator inhibitor type 1 levels (PAI-1); CRC cis rs501916 0.634 rs1561482 chr15:48069663 G/A cg16110827 chr15:48056943 SEMA6D -0.45 -6.46 -0.34 3.74e-10 Inflammatory bowel disease;Ulcerative colitis; CRC cis rs694739 1.000 rs1783521 chr11:64106291 T/C cg02228329 chr11:64053129 BAD;GPR137 0.6 8.98 0.44 2.12e-17 Alopecia areata;Crohn's disease;Psoriasis vulgaris; CRC cis rs7615952 0.641 rs7632497 chr3:125783086 A/C cg15145296 chr3:125709740 NA -0.57 -6.77 -0.35 5.8200000000000003e-11 Blood pressure (smoking interaction); CRC trans rs10507419 1.000 rs17753659 chr13:35187616 T/G cg02971581 chr1:10895950 NA 0.42 5.98 0.31 5.82e-9 Immunoglobulin light chain (AL) amyloidosis (serum Ig lambda profile);Immunoglobulin light chain (AL) amyloidosis (serum IgG profile); CRC cis rs7584330 0.518 rs7561919 chr2:238435241 A/G cg08992911 chr2:238395768 MLPH 0.61 6.32 0.33 8.66e-10 Prostate cancer; CRC cis rs7927771 0.524 rs1563820 chr11:47833398 A/T cg20307385 chr11:47447363 PSMC3 -0.46 -6.74 -0.35 7.09e-11 Subjective well-being; CRC cis rs1552244 0.882 rs3846168 chr3:9996925 C/T cg16606324 chr3:10149918 C3orf24 0.62 8.26 0.41 3.64e-15 Alzheimer's disease; CRC cis rs13108904 0.934 rs13149952 chr4:1308437 C/G cg05665937 chr4:1216051 CTBP1 0.39 5.64 0.3 3.6e-8 Obesity-related traits; CRC cis rs2882667 0.627 rs1549203 chr5:138468344 A/G cg09476006 chr5:138032270 NA -0.41 -6.65 -0.34 1.23e-10 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs4594175 0.847 rs17252303 chr14:51632246 C/T cg23942311 chr14:51606299 NA 0.61 9.58 0.47 2.45e-19 Cancer; CRC cis rs73206853 0.841 rs55972509 chr12:110992755 T/C cg12870014 chr12:110450643 ANKRD13A 0.72 7.58 0.39 3.64e-13 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC cis rs4601790 0.601 rs12801636 chr11:65391317 C/T cg21033440 chr11:65409861 SIPA1 -0.57 -7.87 -0.4 5.28e-14 Blood pressure (age interaction); CRC cis rs703842 1.000 rs3782130 chr12:58161898 G/C cg04478727 chr12:58166393 METTL1;FAM119B 0.42 5.65 0.3 3.48e-8 Multiple sclerosis; CRC trans rs1814175 0.791 rs11040472 chr11:49703116 C/T cg03929089 chr4:120376271 NA -0.97 -18.83 -0.72 3.58e-54 Height; CRC cis rs11098499 0.954 rs6838814 chr4:120392443 G/A cg09307838 chr4:120376055 NA 0.7 10.84 0.51 1.27e-23 Corneal astigmatism; CRC trans rs2727020 0.755 rs652655 chr11:49251293 G/A cg11707556 chr5:10655725 ANKRD33B 0.35 6.29 0.33 1.04e-9 Coronary artery disease; CRC cis rs10504229 0.596 rs6991216 chr8:58115586 T/C cg04204079 chr8:58130323 NA -0.45 -5.78 -0.3 1.71e-8 Developmental language disorder (linguistic errors); CRC cis rs10193935 0.792 rs13423729 chr2:42492874 C/T cg27598129 chr2:42591480 NA -0.47 -5.82 -0.31 1.39e-8 Colonoscopy-negative controls vs population controls; CRC cis rs34779708 0.966 rs2126984 chr10:35410291 A/G cg03585969 chr10:35415529 CREM 0.58 7.85 0.4 5.9e-14 Inflammatory bowel disease;Crohn's disease; CRC cis rs2032447 0.933 rs1540275 chr6:26036476 T/C cg27635394 chr6:26043820 HIST1H2BB 0.43 6.28 0.33 1.06e-9 Intelligence (multi-trait analysis); CRC cis rs6502050 0.799 rs4789673 chr17:80123218 T/C cg11859384 chr17:80120422 CCDC57 -0.36 -5.75 -0.3 2.06e-8 Life satisfaction; CRC cis rs2836950 0.509 rs11088466 chr21:40580017 T/A cg06238570 chr21:40685208 BRWD1 -0.6 -8.78 -0.44 8.93e-17 Menarche (age at onset); CRC trans rs1005277 0.579 rs2474569 chr10:38383491 C/G cg11292332 chr7:45801988 SEPT13 -0.35 -6.26 -0.33 1.23e-9 Extrinsic epigenetic age acceleration; CRC cis rs1046896 0.739 rs2379358 chr17:80741612 G/A cg19500275 chr17:80737654 TBCD 0.52 7.26 0.37 2.84e-12 Glycated hemoglobin levels; CRC cis rs9976767 0.637 rs2156309 chr21:43824529 G/A cg23042151 chr21:43824109 UBASH3A -0.43 -7.43 -0.38 9.26e-13 Type 1 diabetes; CRC cis rs28386778 0.897 rs2597634 chr17:61878144 G/A cg07362569 chr17:61921086 SMARCD2 0.37 5.7 0.3 2.64e-8 Prudent dietary pattern; CRC cis rs2276314 1.000 rs56050783 chr18:33553791 A/G cg19628046 chr18:33552617 C18orf21 0.47 6.51 0.34 2.73e-10 Endometriosis;Drug-induced torsades de pointes; CRC cis rs10845606 1.000 rs10845607 chr12:12835228 C/T cg04607235 chr12:12878440 APOLD1 -0.54 -5.69 -0.3 2.83e-8 Systemic lupus erythematosus; CRC cis rs9326248 0.603 rs7396061 chr11:116750874 A/C cg20608306 chr11:116969690 SIK3 0.34 7.03 0.36 1.22e-11 Blood protein levels; CRC cis rs4713675 0.565 rs4713659 chr6:33667839 A/G cg14003231 chr6:33640908 ITPR3 0.48 7.95 0.4 3.12e-14 Plateletcrit; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg05432305 chr3:33840003 PDCD6IP 0.44 6.34 0.33 7.4e-10 Intelligence (multi-trait analysis); CRC cis rs2952156 1.000 rs2952156 chr17:37876835 A/G cg11212589 chr17:38028394 ZPBP2 0.34 5.68 0.3 2.94e-8 Asthma; CRC cis rs12431939 0.571 rs7493931 chr14:51736401 T/C cg23942311 chr14:51606299 NA 0.54 7.14 0.37 6.09e-12 Cancer; CRC cis rs8102476 0.846 rs11083450 chr19:38754239 T/C cg14131526 chr19:38747285 PPP1R14A -0.36 -6.36 -0.33 6.8e-10 Prostate cancer;Prostate cancer (SNP x SNP interaction); CRC cis rs7487075 0.619 rs10748448 chr12:46803338 C/T cg22049899 chr12:47219821 SLC38A4 0.31 5.73 0.3 2.22e-8 Itch intensity from mosquito bite; CRC cis rs9467711 0.606 rs35076545 chr6:26603924 C/A cg12315302 chr6:26189340 HIST1H4D 0.99 6.93 0.36 2.22e-11 Autism spectrum disorder or schizophrenia; CRC cis rs6912958 0.559 rs2985039 chr6:88041757 A/G cg12350822 chr6:88032061 C6orf162;GJB7 0.5 10.24 0.49 1.54e-21 Monocyte percentage of white cells; CRC cis rs7945705 0.875 rs10769947 chr11:8758114 A/G cg21881798 chr11:8931708 C11orf17;ST5 0.5 7.4 0.38 1.18e-12 Hemoglobin concentration; CRC trans rs1814175 0.618 rs1851843 chr11:50021846 T/C cg03929089 chr4:120376271 NA -0.88 -15.84 -0.66 2.09e-42 Height; CRC cis rs6598955 0.950 rs6700455 chr1:26545864 T/C cg00852783 chr1:26633632 UBXN11 -0.39 -5.71 -0.3 2.51e-8 Obesity-related traits; CRC cis rs4629710 0.592 rs13205441 chr6:131575069 G/A cg12606694 chr6:131520996 AKAP7 0.58 8.56 0.43 4.46e-16 Multiple myeloma (IgH translocation); CRC cis rs3733585 0.699 rs7677710 chr4:9969517 T/G cg11266682 chr4:10021025 SLC2A9 -0.46 -9.42 -0.46 8.4e-19 Cleft plate (environmental tobacco smoke interaction); CRC cis rs898097 0.607 rs2199111 chr17:80823203 A/G cg19046167 chr17:80928561 B3GNTL1 -0.43 -7.21 -0.37 3.76e-12 Breast cancer; CRC cis rs2730245 0.550 rs2709860 chr7:158651156 A/T cg24397884 chr7:158709396 WDR60 0.83 13.11 0.59 6.83e-32 Height; CRC cis rs7827545 0.960 rs1372661 chr8:135566859 A/G cg17885191 chr8:135476712 NA 0.52 7.03 0.36 1.18e-11 Hypertension (SNP x SNP interaction); CRC cis rs12477438 0.953 rs3851334 chr2:99794704 T/C cg14399236 chr2:99771627 LIPT1;TSGA10 -0.7 -8.54 -0.43 4.91e-16 Chronic sinus infection; CRC cis rs7727544 0.507 rs11741341 chr5:131570218 A/G cg18301423 chr5:131593218 PDLIM4 0.42 7.64 0.39 2.33e-13 Blood metabolite levels; CRC cis rs7259376 0.623 rs59533346 chr19:22484182 C/T cg02657401 chr19:22469223 NA -0.3 -6.56 -0.34 2.07e-10 Menopause (age at onset); CRC cis rs12908161 0.960 rs34452033 chr15:85221993 A/G cg17507749 chr15:85114479 UBE2QP1 0.63 8.91 0.44 3.45e-17 Schizophrenia; CRC trans rs35110281 0.807 rs1598206 chr21:45058776 A/G cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.41 6.62 0.34 1.43e-10 Mean corpuscular volume; CRC cis rs6499255 0.951 rs76407217 chr16:69690355 A/T cg04110750 chr16:69646130 NFAT5 -0.53 -7.43 -0.38 9.15e-13 IgE levels; CRC cis rs873946 0.590 rs12783478 chr10:134550700 A/G cg26818010 chr10:134567672 INPP5A -0.55 -7.72 -0.39 1.36e-13 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CRC cis rs9611565 0.659 rs9611602 chr22:41908405 T/C cg06634786 chr22:41940651 POLR3H -0.66 -7.74 -0.39 1.27e-13 Vitiligo; CRC cis rs1552244 0.572 rs67439440 chr3:10169503 C/T cg10729496 chr3:10149963 C3orf24 0.48 5.63 0.3 3.81e-8 Alzheimer's disease; CRC cis rs9399135 0.967 rs7741515 chr6:135374368 C/G cg22676075 chr6:135203613 NA -0.41 -6.4 -0.33 5.43e-10 Red blood cell count; CRC cis rs909002 0.849 rs10753257 chr1:32086089 G/A cg13919466 chr1:32135498 COL16A1 -0.32 -6.09 -0.32 3.09e-9 Intelligence (multi-trait analysis); CRC cis rs9486719 0.948 rs11152952 chr6:96894303 A/G cg06623918 chr6:96969491 KIAA0776 -0.81 -9.51 -0.46 4.17e-19 Migraine;Coronary artery disease; CRC cis rs1552244 1.000 rs61077902 chr3:10126153 T/G cg10729496 chr3:10149963 C3orf24 0.56 7.51 0.38 5.64e-13 Alzheimer's disease; CRC cis rs7412746 0.611 rs2256355 chr1:150811794 A/G cg17724175 chr1:150552817 MCL1 0.44 6.66 0.34 1.15e-10 Melanoma; CRC cis rs875971 0.928 rs2036263 chr7:65800197 C/T cg18252515 chr7:66147081 NA 0.4 5.79 0.3 1.63e-8 Aortic root size; CRC cis rs35146811 0.586 rs10267212 chr7:99595422 T/C cg13334819 chr7:99746414 C7orf59 -0.46 -6.31 -0.33 9.18e-10 Coronary artery disease; CRC cis rs6860806 0.507 rs272892 chr5:131664349 C/T cg11843238 chr5:131593191 PDLIM4 0.43 7.23 0.37 3.3e-12 Breast cancer; CRC cis rs10504229 0.639 rs72650811 chr8:58115661 G/A cg04204079 chr8:58130323 NA -0.45 -5.78 -0.3 1.71e-8 Developmental language disorder (linguistic errors); CRC cis rs3091242 0.904 rs6661533 chr1:25771715 A/G cg02931644 chr1:25747376 RHCE 0.32 5.68 0.3 2.94e-8 Erythrocyte sedimentation rate; CRC cis rs919433 0.783 rs788014 chr2:198228997 G/A cg10820045 chr2:198174542 NA 0.45 7.79 0.39 8.73e-14 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC cis rs2180341 0.596 rs12215298 chr6:127676833 C/T cg24812749 chr6:127587940 RNF146 0.68 10.11 0.49 4.11e-21 Breast cancer; CRC cis rs6582630 0.519 rs8189561 chr12:38296178 G/A cg26384229 chr12:38710491 ALG10B 0.69 9.74 0.47 7.18e-20 Drug-induced liver injury (flucloxacillin); CRC cis rs12134245 0.874 rs17501937 chr1:92021705 C/T cg02896835 chr1:92012615 NA 0.47 7.47 0.38 7.28e-13 Breast cancer; CRC cis rs769267 1.000 rs3764567 chr19:19440066 C/T cg02546618 chr19:19431379 KIAA0892;SF4 -0.46 -6.19 -0.32 1.79e-9 Tonsillectomy; CRC cis rs13256369 0.901 rs12681298 chr8:8566235 A/G cg17143192 chr8:8559678 CLDN23 -0.55 -7.7 -0.39 1.63e-13 Obesity-related traits; CRC cis rs6701037 1.000 rs6702010 chr1:175123858 C/A cg00321850 chr1:175162397 KIAA0040 -0.36 -5.9 -0.31 8.95e-9 Alcohol dependence; CRC cis rs10924970 0.904 rs10924500 chr1:235351436 T/G cg26050004 chr1:235667680 B3GALNT2 0.39 5.77 0.3 1.88e-8 Asthma; CRC cis rs2836950 0.520 rs8133927 chr21:40689961 G/T cg17971929 chr21:40555470 PSMG1 -0.52 -7.38 -0.38 1.34e-12 Menarche (age at onset); CRC cis rs4509693 1.000 rs4509693 chr10:102501571 C/T cg23167259 chr10:102495509 NA -0.49 -6.76 -0.35 6.28e-11 Alzheimer's disease; CRC cis rs7917772 0.502 rs2296584 chr10:104244323 T/A cg22532475 chr10:104410764 TRIM8 -0.36 -6.5 -0.34 2.95e-10 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC cis rs832540 0.629 rs10940512 chr5:56082094 G/C cg03609598 chr5:56110824 MAP3K1 -0.45 -6.09 -0.32 3.22e-9 Coronary artery disease; CRC cis rs4689388 0.853 rs13103357 chr4:6294544 A/G cg14416269 chr4:6271139 WFS1 0.4 6.59 0.34 1.72e-10 Type 2 diabetes and other traits;Type 2 diabetes; CRC cis rs4713118 0.513 rs149962 chr6:28015918 G/A cg15845792 chr6:28175446 NA 0.77 11.33 0.53 2.33e-25 Parkinson's disease; CRC cis rs9372498 0.536 rs9320660 chr6:118956827 A/T cg07617317 chr6:118971624 C6orf204 0.47 5.69 0.3 2.79e-8 Diastolic blood pressure; CRC cis rs13392177 0.647 rs6718220 chr2:219066518 T/C cg04731861 chr2:219085781 ARPC2 0.33 6.54 0.34 2.37e-10 Pyoderma gangrenosum in inflammatory bowel disease; CRC cis rs2836974 0.897 rs68090597 chr21:40535633 A/G cg11644478 chr21:40555479 PSMG1 0.83 13.85 0.61 1.09e-34 Cognitive function; CRC cis rs4917300 0.549 rs902819 chr8:143098548 C/T cg25363559 chr8:143086065 NA -0.34 -6.49 -0.34 3.22e-10 Amyotrophic lateral sclerosis; CRC cis rs6951245 0.872 rs77434655 chr7:1098405 G/A cg18402987 chr7:1209562 NA 0.67 7.17 0.37 5.02e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs10170846 0.800 rs10194743 chr2:223518151 A/G cg25565276 chr2:223520875 FARSB 0.5 6.74 0.35 7.2e-11 Schizophrenia (inflammation and infection response interaction); CRC cis rs2404602 0.684 rs3910756 chr15:76945369 C/T cg23625390 chr15:77176239 SCAPER -0.77 -10.71 -0.51 3.74e-23 Blood metabolite levels; CRC cis rs796364 0.760 rs2881594 chr2:201026183 T/A cg25936922 chr2:200820526 C2orf60;C2orf47 -0.64 -5.81 -0.31 1.48e-8 Schizophrenia; CRC trans rs959260 0.557 rs12936583 chr17:73304710 A/C cg02778551 chr7:1045947 C7orf50 -0.45 -6.73 -0.35 7.76e-11 Systemic lupus erythematosus; CRC cis rs7772486 0.681 rs9390343 chr6:146010527 A/T cg13319975 chr6:146136371 FBXO30 0.39 5.72 0.3 2.33e-8 Lobe attachment (rater-scored or self-reported); CRC cis rs17065868 0.764 rs9533862 chr13:45034814 G/C cg10246903 chr13:45222710 NA 0.54 5.69 0.3 2.79e-8 Antineutrophil cytoplasmic antibody-associated vasculitis; CRC cis rs9486719 0.857 rs1157316 chr6:96869710 G/A cg06623918 chr6:96969491 KIAA0776 0.83 11.29 0.53 3.31e-25 Migraine;Coronary artery disease; CRC cis rs13191362 1.000 rs73035023 chr6:163000927 C/T cg21926612 chr6:163149169 PACRG;PARK2 0.82 11.39 0.53 1.52e-25 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs2032447 0.714 rs199734 chr6:25940393 G/C cg15691649 chr6:25882328 NA -0.45 -6.01 -0.31 5.04e-9 Intelligence (multi-trait analysis); CRC trans rs1997103 1.000 rs2877284 chr7:55408778 A/G cg20935933 chr6:143382018 AIG1 0.51 6.65 0.34 1.25e-10 QRS interval (sulfonylurea treatment interaction); CRC cis rs7258465 1.000 rs4808133 chr19:18608518 C/A cg06953865 chr19:18549723 ISYNA1 -0.37 -5.65 -0.3 3.56e-8 Breast cancer; CRC cis rs2032447 0.507 rs199748 chr6:25909045 C/G cg04800585 chr6:26043546 HIST1H2BB 0.45 6.13 0.32 2.5e-9 Intelligence (multi-trait analysis); CRC cis rs13161895 1.000 rs34674199 chr5:179473900 G/A cg02702477 chr5:179499311 RNF130 0.55 6.26 0.33 1.18e-9 LDL cholesterol; CRC cis rs1218582 0.628 rs12130132 chr1:154880386 C/T cg12436631 chr1:155007014 DCST1;DCST2 0.36 5.77 0.3 1.82e-8 Prostate cancer; CRC cis rs2692947 0.666 rs7566050 chr2:96626030 T/C cg23100626 chr2:96804247 ASTL 0.26 7.0 0.36 1.47e-11 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; CRC cis rs9640161 0.659 rs7806429 chr7:150013393 A/G cg12556325 chr7:150026731 C7orf29;LRRC61 -0.41 -6.52 -0.34 2.61e-10 Blood protein levels;Circulating chemerin levels; CRC cis rs798554 0.679 rs1614791 chr7:2888057 G/T cg13628971 chr7:2884303 GNA12 0.62 8.57 0.43 4.22e-16 Height; CRC cis rs2777491 0.789 rs316617 chr15:41795900 C/T cg18705301 chr15:41695430 NDUFAF1 0.61 10.15 0.49 3.18e-21 Ulcerative colitis; CRC cis rs10504229 0.683 rs55645894 chr8:58116145 A/G cg21724239 chr8:58056113 NA 0.49 6.81 0.35 4.75e-11 Developmental language disorder (linguistic errors); CRC trans rs3942852 0.568 rs10838800 chr11:48094879 C/T cg15704280 chr7:45808275 SEPT13 -0.69 -9.75 -0.47 6.88e-20 Acute lymphoblastic leukemia (childhood); CRC cis rs2976388 0.507 rs13259549 chr8:143838519 T/C cg04969067 chr8:143858791 LYNX1 0.59 10.09 0.49 4.97e-21 Urinary tract infection frequency; CRC cis rs67311347 1.000 rs11707278 chr3:40487075 A/T cg09455208 chr3:40491958 NA 0.47 9.24 0.45 3.19e-18 Renal cell carcinoma; CRC cis rs11758351 1.000 rs11758351 chr6:26203910 T/G cg10723962 chr6:26240782 HIST1H4F -0.37 -5.76 -0.3 1.94e-8 Gout;Renal underexcretion gout; CRC cis rs780094 0.500 rs4665991 chr2:27766284 G/A cg27432699 chr2:27873401 GPN1 0.46 5.82 0.31 1.43e-8 Calcium levels;Fasting blood insulin;Metabolic traits;Triglyceride levels;Fasting plasma glucose;Urate levels in overweight individuals;Urate levels in obese individuals;Uric acid levels;Height;Age-related diseases, mortality and associated endophenotypes;Renal underexcretion gout;Fasting blood glucose (BMI interaction);Urate levels;Gondoic acid (20:1n-9) levels;Fasting blood insulin (BMI interaction);Triglycerides;Plasma omega-3 polyunsaturated fatty acid levels (docosapentaenoic acid);Type 2 diabetes;Nonalcoholic fatty liver disease;Hypertriglyceridemia;C-reactive protein;Age-related disease endophenotypes;LDL cholesterol;Metabolic syndrome;Crohn's disease;Alcohol consumption (drinks per week);Homeostasis model assessment of insulin resistance;Alcohol consumption;Red blood cell count;Fasting blood glucose; CRC cis rs9916302 0.800 rs9892675 chr17:37549200 C/T cg07936489 chr17:37558343 FBXL20 0.94 13.69 0.6 4.45e-34 Glomerular filtration rate (creatinine); CRC cis rs4363385 0.818 rs3806223 chr1:153002646 T/C cg25856811 chr1:152973957 SPRR3 -0.26 -7.16 -0.37 5.44e-12 Inflammatory skin disease; CRC cis rs1670533 0.932 rs2045067 chr4:1052355 C/T cg27284194 chr4:1044797 NA 0.5 6.2 0.32 1.66e-9 Recombination rate (females); CRC cis rs2019137 0.539 rs4849177 chr2:113982584 T/C cg19083407 chr2:113993142 PAX8;LOC440839;LOC654433 0.58 8.74 0.43 1.2e-16 Lymphocyte counts; CRC cis rs10979 1.000 rs13211390 chr6:143888010 A/T cg25407410 chr6:143891975 LOC285740 -0.8 -13.23 -0.59 2.41e-32 Hypospadias; CRC cis rs736408 0.660 rs2019065 chr3:52809525 C/T cg10802521 chr3:52805072 NEK4 0.53 8.19 0.41 5.77e-15 Bipolar disorder; CRC cis rs6840360 0.550 rs62327267 chr4:152518753 G/T cg09659197 chr4:152720779 NA 0.3 5.62 0.3 4.07e-8 Intelligence (multi-trait analysis); CRC cis rs12142240 0.698 rs6695043 chr1:46844530 A/G cg14993813 chr1:46806288 NSUN4 0.52 6.33 0.33 8e-10 Menopause (age at onset); CRC cis rs3744061 0.776 rs9916811 chr17:74749273 C/T cg13533061 chr17:74712429 JMJD6 0.44 6.92 0.36 2.32e-11 Retinal arteriolar caliber; CRC trans rs2014572 0.901 rs35658377 chr19:57755627 T/G cg02674126 chr19:40336878 FBL 0.43 6.89 0.36 2.84e-11 Hyperactive-impulsive symptoms; CRC cis rs7178572 0.568 rs7176302 chr15:77671216 C/G cg22256960 chr15:77711686 NA -0.64 -9.24 -0.45 3.07e-18 Type 2 diabetes; CRC cis rs7769051 1.000 rs73554431 chr6:133129922 T/G cg07930552 chr6:133119739 C6orf192 0.61 7.3 0.37 2.14e-12 Type 2 diabetes nephropathy; CRC cis rs9427116 1.000 rs9427117 chr1:154632231 C/G cg24304309 chr1:154577895 ADAR 0.37 6.07 0.32 3.61e-9 Blood protein levels; CRC cis rs10992471 0.756 rs7043152 chr9:95138499 A/G cg13798575 chr9:95087839 CENPP;NOL8 -0.48 -6.97 -0.36 1.79e-11 Visceral adipose tissue/subcutaneous adipose tissue ratio; CRC cis rs6762 0.748 rs28735718 chr11:839629 A/G cg15787769 chr11:842744 TSPAN4;POLR2L -0.47 -6.63 -0.34 1.36e-10 Mean platelet volume; CRC cis rs514406 0.584 rs7524702 chr1:53197830 G/A cg27535305 chr1:53392650 SCP2 0.36 6.39 0.33 5.78e-10 Monocyte count; CRC cis rs6761276 0.649 rs3811055 chr2:113831182 A/T cg24553058 chr2:113831203 IL1F10 0.55 8.64 0.43 2.47e-16 Protein quantitative trait loci; CRC cis rs875971 0.660 rs10272357 chr7:66063074 G/A cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.43 -6.32 -0.33 8.42e-10 Aortic root size; CRC cis rs8036030 0.604 rs11856835 chr15:74716174 G/A cg10253484 chr15:75165896 SCAMP2 -0.42 -5.94 -0.31 7.26e-9 Airflow obstruction; CRC cis rs1552244 1.000 rs6768102 chr3:10149380 A/G cg13047869 chr3:10149882 C3orf24 0.56 7.66 0.39 2.11e-13 Alzheimer's disease; CRC trans rs7395662 0.571 rs4882020 chr11:48615658 C/T cg21153622 chr11:89784906 NA -0.52 -8.68 -0.43 1.92e-16 HDL cholesterol; CRC cis rs7072216 0.770 rs1739 chr10:100176339 A/G cg26618903 chr10:100175079 PYROXD2 -0.45 -7.45 -0.38 8.11e-13 Metabolite levels; CRC cis rs763121 0.853 rs2413544 chr22:39059404 A/C cg06544989 chr22:39130855 UNC84B 0.45 6.86 0.35 3.33e-11 Menopause (age at onset); CRC cis rs3764400 0.517 rs7224461 chr17:46203430 C/G cg10706073 chr17:46328419 SKAP1 0.6 6.25 0.33 1.25e-9 Body mass index; CRC cis rs72781680 0.716 rs72788206 chr2:24084989 T/C cg08917208 chr2:24149416 ATAD2B 0.56 6.83 0.35 4.14e-11 Lymphocyte counts; CRC cis rs72945132 0.882 rs56176527 chr11:70162513 A/G cg00319359 chr11:70116639 PPFIA1 0.67 7.46 0.38 7.95e-13 Coronary artery disease; CRC cis rs4743820 0.651 rs16907199 chr9:93923617 A/G cg14446406 chr9:93919335 NA 0.78 14.45 0.62 5.63e-37 Ulcerative colitis;Inflammatory bowel disease; CRC cis rs9911578 0.874 rs302874 chr17:56767996 A/G cg05425664 chr17:57184151 TRIM37 -0.48 -7.64 -0.39 2.46e-13 Intelligence (multi-trait analysis); CRC cis rs17711722 0.653 rs2460421 chr7:65491123 A/T cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.52 -7.54 -0.38 4.58e-13 Calcium levels; CRC cis rs6120849 0.615 rs11167248 chr20:33538721 G/T cg08999081 chr20:33150536 PIGU 0.44 5.71 0.3 2.47e-8 Protein C levels; CRC cis rs7927771 0.832 rs10769258 chr11:47391039 C/T cg18512352 chr11:47633146 NA 0.34 6.56 0.34 2.04e-10 Subjective well-being; CRC cis rs7385804 0.761 rs576236 chr7:100316975 C/T cg20848291 chr7:100343083 ZAN 0.5 7.51 0.38 5.45e-13 Iron status biomarkers;Mean corpuscular hemoglobin;Hematocrit;Iron status biomarkers (transferrin saturation);Red blood cell count;Iron status biomarkers (iron levels);Mean corpuscular volume;Hematological parameters; CRC cis rs9399135 0.967 rs1041481 chr6:135335063 G/A cg24558204 chr6:135376177 HBS1L 0.51 8.12 0.41 9.53e-15 Red blood cell count; CRC cis rs6665290 0.935 rs6670924 chr1:227196048 A/C cg10327440 chr1:227177885 CDC42BPA -1.04 -23.33 -0.79 9.69e-72 Myeloid white cell count; CRC cis rs1832871 0.711 rs9457248 chr6:158681204 C/T cg07165851 chr6:158734300 TULP4 0.61 7.72 0.39 1.37e-13 Height; CRC cis rs3733585 0.699 rs4339211 chr4:9947658 C/T cg11266682 chr4:10021025 SLC2A9 -0.46 -9.29 -0.46 2.19e-18 Cleft plate (environmental tobacco smoke interaction); CRC cis rs1784581 0.651 rs3016568 chr6:162388158 G/A cg17173639 chr6:162384350 PARK2 -0.74 -12.41 -0.56 2.8e-29 Itch intensity from mosquito bite; CRC cis rs853679 0.517 rs9295761 chr6:28147987 A/G cg12172441 chr6:28176163 NA 0.65 7.64 0.39 2.39e-13 Depression; CRC trans rs3780486 0.505 rs7868663 chr9:33141229 A/G cg04842962 chr6:43655489 MRPS18A 0.96 17.29 0.69 4.24e-48 IgG glycosylation; CRC cis rs9398803 0.865 rs9375446 chr6:126835015 G/A cg19875578 chr6:126661172 C6orf173 0.42 5.86 0.31 1.15e-8 Male-pattern baldness; CRC cis rs7605827 0.930 rs2287260 chr2:15624810 T/C cg19274914 chr2:15703543 NA 0.37 5.7 0.3 2.64e-8 Educational attainment (years of education); CRC trans rs12599106 0.709 rs1501462 chr16:34964515 A/T cg11235426 chr6:292522 DUSP22 -0.67 -9.65 -0.47 1.45e-19 Menopause (age at onset); CRC cis rs4604732 1.000 rs4604732 chr1:247623872 C/T cg02104434 chr1:247694406 LOC148824;OR2C3 -0.47 -7.3 -0.37 2.2e-12 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CRC cis rs798554 0.836 rs798502 chr7:2789880 G/T cg19717773 chr7:2847554 GNA12 0.43 6.36 0.33 6.56e-10 Height; CRC cis rs12545109 0.765 rs2438063 chr8:57384360 A/G cg09654669 chr8:57350985 NA 0.41 5.87 0.31 1.08e-8 Obesity-related traits; CRC cis rs8180040 0.620 rs11715121 chr3:47072621 T/A cg02527881 chr3:46936655 PTH1R 0.33 5.66 0.3 3.33e-8 Colorectal cancer; CRC cis rs9796 0.621 rs1659228 chr15:41471978 A/G cg18705301 chr15:41695430 NDUFAF1 -0.42 -6.98 -0.36 1.6e-11 Menopause (age at onset); CRC cis rs1670533 0.818 rs643484 chr4:1085826 A/G cg27284194 chr4:1044797 NA 0.5 6.33 0.33 7.9e-10 Recombination rate (females); CRC cis rs7589728 0.563 rs80324973 chr2:88447264 T/G cg18490616 chr2:88469792 THNSL2 0.61 6.1 0.32 2.9e-9 Plasma clusterin levels; CRC cis rs10751667 0.666 rs6597957 chr11:982294 T/A cg06064525 chr11:970664 AP2A2 -0.34 -6.72 -0.35 7.81e-11 Alzheimer's disease (late onset); CRC cis rs9733 0.596 rs34600506 chr1:150687808 C/G cg10589385 chr1:150898437 SETDB1 0.28 5.96 0.31 6.66e-9 Tonsillectomy; CRC trans rs7647973 0.560 rs77473999 chr3:49777660 T/C cg21659725 chr3:3221576 CRBN 0.61 6.29 0.33 1.03e-9 Menarche (age at onset); CRC cis rs4663969 0.873 rs759174 chr2:234668245 A/C cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.47 -7.4 -0.38 1.15e-12 Total bilirubin levels in HIV-1 infection; CRC cis rs2732480 0.577 rs2732481 chr12:48736985 T/G cg24011408 chr12:48396354 COL2A1 0.47 6.36 0.33 6.59e-10 Hemoglobin concentration;Red blood cell count;Hematocrit; CRC cis rs6662572 0.737 rs6659064 chr1:46346724 G/C cg03123370 chr1:45965343 CCDC163P;MMACHC -0.46 -5.9 -0.31 8.93e-9 Blood protein levels; CRC cis rs6754311 0.678 rs309181 chr2:136614813 C/G cg25344623 chr2:136566232 LCT 0.33 5.98 0.31 5.97e-9 Mosquito bite size; CRC cis rs72781680 0.561 rs72783615 chr2:24296397 C/A cg06627628 chr2:24431161 ITSN2 -0.54 -6.17 -0.32 1.99e-9 Lymphocyte counts; CRC cis rs9487051 0.837 rs1915834 chr6:109597624 C/A cg21918786 chr6:109611834 NA -0.43 -7.85 -0.4 5.81e-14 Reticulocyte fraction of red cells; CRC cis rs1552244 0.872 rs6771931 chr3:10113408 C/G cg08888203 chr3:10149979 C3orf24 0.7 9.84 0.48 3.31e-20 Alzheimer's disease; CRC cis rs10504229 0.683 rs35840293 chr8:58117634 C/T cg02290350 chr8:58132656 NA -0.58 -8.16 -0.41 7.29e-15 Developmental language disorder (linguistic errors); CRC cis rs3785574 0.962 rs2665835 chr17:61903258 C/T cg23090583 chr17:61904693 PSMC5;FTSJ3 0.65 9.26 0.45 2.71e-18 Height; CRC cis rs7726839 0.540 rs4957083 chr5:659343 T/C cg16447950 chr5:562315 NA -0.77 -10.08 -0.49 5.3e-21 Obesity-related traits; CRC cis rs9326248 0.861 rs7931335 chr11:117036805 C/T cg11861562 chr11:117069780 TAGLN 0.33 6.08 0.32 3.34e-9 Blood protein levels; CRC cis rs6860806 0.507 rs273901 chr5:131694360 G/T cg24060327 chr5:131705240 SLC22A5 -0.53 -7.94 -0.4 3.23e-14 Breast cancer; CRC cis rs7552404 0.889 rs380075 chr1:76106961 T/A cg22875332 chr1:76189707 ACADM -0.67 -9.0 -0.44 1.87e-17 Blood metabolite levels;Acylcarnitine levels; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg24060473 chr17:30228954 UTP6 0.43 6.0 0.31 5.06e-9 Anxiety disorder; CRC cis rs4713118 0.539 rs510987 chr6:27847517 G/A cg06470822 chr6:28175283 NA 0.78 11.02 0.52 3.05e-24 Parkinson's disease; CRC cis rs7178572 0.889 rs11857450 chr15:77802791 C/G cg22256960 chr15:77711686 NA 0.62 9.42 0.46 8.43e-19 Type 2 diabetes; CRC trans rs6897795 0.680 rs9329137 chr5:177616370 C/T cg19598605 chr2:70056955 GMCL1 -0.7 -8.62 -0.43 2.92e-16 Plateletcrit; CRC cis rs10540 0.730 rs12789735 chr11:518509 G/A cg08200582 chr11:442649 ANO9 -0.71 -7.3 -0.37 2.19e-12 Body mass index; CRC cis rs6460942 1.000 rs2053382 chr7:12400587 A/G cg06484146 chr7:12443880 VWDE -0.77 -7.56 -0.38 4.16e-13 Coronary artery disease; CRC cis rs6502050 0.787 rs8080682 chr17:80058901 G/A cg22110888 chr17:80059540 CCDC57 -0.45 -7.02 -0.36 1.3e-11 Life satisfaction; CRC cis rs2304069 0.507 rs7728264 chr5:149394954 C/G cg12661370 chr5:149340060 SLC26A2 0.43 6.21 0.32 1.62e-9 HIV-1 control; CRC cis rs11122272 0.735 rs973254 chr1:231521149 T/A cg06096015 chr1:231504339 EGLN1 0.39 5.89 0.31 9.62e-9 Hemoglobin concentration; CRC cis rs762407 0.925 rs4594536 chr21:45164854 C/T cg24875593 chr21:45153009 PDXK -0.42 -6.34 -0.33 7.48e-10 Systolic blood pressure change trajectories; CRC cis rs1552244 0.608 rs6764807 chr3:9998803 T/C cg18598329 chr3:10140678 FANCD2;C3orf24 -0.52 -7.53 -0.38 5.05e-13 Alzheimer's disease; CRC cis rs780096 0.506 rs1647285 chr2:27714511 A/C cg24768116 chr2:27665128 KRTCAP3 -0.38 -8.69 -0.43 1.69e-16 Total body bone mineral density; CRC cis rs898097 0.690 rs12452304 chr17:80811659 G/A cg16060761 chr17:80687452 NA 0.42 6.16 0.32 2.11e-9 Breast cancer; CRC cis rs826838 0.616 rs10880738 chr12:38617762 C/T cg13010199 chr12:38710504 ALG10B -0.42 -6.03 -0.32 4.33e-9 Heart rate; CRC cis rs7119 0.717 rs12904254 chr15:77802585 C/A cg10437265 chr15:77819839 NA 0.66 11.6 0.54 2.63e-26 Type 2 diabetes; CRC cis rs9322193 0.923 rs9322204 chr6:149957183 A/C cg05861140 chr6:150128134 PCMT1 -0.36 -5.97 -0.31 6.27e-9 Lung cancer; CRC cis rs929354 0.742 rs7784442 chr7:156934475 G/C cg16102536 chr7:156981717 UBE3C 0.4 6.69 0.35 9.57e-11 Body mass index; CRC cis rs9308731 0.666 rs4849402 chr2:111873932 G/A cg04202892 chr2:111875749 ACOXL 0.43 6.97 0.36 1.74e-11 Chronic lymphocytic leukemia; CRC cis rs9660180 0.875 rs4648727 chr1:1776269 C/A cg03396347 chr1:1875803 NA 0.52 8.09 0.41 1.17e-14 Body mass index; CRC cis rs7705042 0.865 rs6580225 chr5:141489381 G/C cg08523384 chr5:141488047 NDFIP1 -0.33 -5.86 -0.31 1.14e-8 Asthma; CRC cis rs6714710 0.603 rs2305143 chr2:98413781 C/T cg26665480 chr2:98280029 ACTR1B 0.52 7.18 0.37 4.53e-12 Posterior cortical atrophy and Alzheimer's disease; CRC cis rs10992471 0.756 rs11792342 chr9:95143668 G/A cg13798575 chr9:95087839 CENPP;NOL8 -0.48 -6.97 -0.36 1.79e-11 Visceral adipose tissue/subcutaneous adipose tissue ratio; CRC cis rs9467711 0.606 rs9348726 chr6:26605206 G/A cg16898833 chr6:26189333 HIST1H4D 0.94 7.7 0.39 1.64e-13 Autism spectrum disorder or schizophrenia; CRC cis rs10189230 0.967 rs12990760 chr2:222354725 G/T cg14652038 chr2:222343519 EPHA4 0.52 10.02 0.48 8.14e-21 Urate levels in lean individuals; CRC cis rs3617 0.625 rs2535633 chr3:52859630 C/G cg18099408 chr3:52552593 STAB1 0.35 6.15 0.32 2.28e-9 Red blood cell count;Autism spectrum disorder or schizophrenia; CRC cis rs2463822 0.669 rs72919496 chr11:62052730 T/C cg06239285 chr11:62104954 ASRGL1 -0.88 -8.66 -0.43 2.09e-16 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs2739330 0.828 rs2330635 chr22:24251344 T/C cg11060661 chr22:24314208 DDT;DDTL 0.51 8.53 0.43 5.27e-16 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs736408 0.500 rs2878762 chr3:52919002 T/C cg10802521 chr3:52805072 NEK4 -0.48 -6.82 -0.35 4.5e-11 Bipolar disorder; CRC cis rs3785574 0.962 rs2727332 chr17:61878584 T/A cg06873352 chr17:61820015 STRADA 0.5 8.02 0.4 1.93e-14 Height; CRC cis rs11030122 0.673 rs4910597 chr11:4094923 G/A cg18678763 chr11:4115507 RRM1 -0.54 -8.65 -0.43 2.34e-16 Mean platelet volume;Platelet distribution width; CRC cis rs11971779 0.553 rs36002669 chr7:139113161 T/A cg23387468 chr7:139079360 LUC7L2 0.4 6.72 0.35 7.93e-11 Diisocyanate-induced asthma; CRC cis rs7618915 0.547 rs62255371 chr3:52747321 A/G cg08222913 chr3:52553049 STAB1 -0.34 -6.15 -0.32 2.29e-9 Bipolar disorder; CRC trans rs1997103 1.000 rs2177802 chr7:55410789 G/A cg20935933 chr6:143382018 AIG1 0.51 6.65 0.34 1.25e-10 QRS interval (sulfonylurea treatment interaction); CRC cis rs2718058 0.613 rs2597272 chr7:37759710 C/G cg24998770 chr7:37888106 TXNDC3 -0.36 -5.8 -0.3 1.58e-8 Alzheimer's disease (late onset); CRC cis rs1552244 0.882 rs34779351 chr3:10021801 A/G cg16606324 chr3:10149918 C3orf24 0.61 7.98 0.4 2.47e-14 Alzheimer's disease; CRC cis rs4713118 0.512 rs2622319 chr6:28120401 G/C cg21251018 chr6:28226885 NKAPL 0.46 6.93 0.36 2.19e-11 Parkinson's disease; CRC trans rs4843747 0.671 rs74729706 chr16:88104159 C/T cg26811252 chr16:29126840 RRN3P2 0.65 8.73 0.43 1.31e-16 Menopause (age at onset); CRC cis rs3213961 0.554 rs8256 chr2:33789068 C/G cg04131969 chr2:33951647 MYADML 0.42 5.68 0.3 3.03e-8 Venous thromboembolism adjusted for sickle cell variant rs77121243-T; CRC cis rs780094 0.585 rs3739095 chr2:27556721 C/T cg24768116 chr2:27665128 KRTCAP3 -0.3 -6.68 -0.35 1.02e-10 Calcium levels;Fasting blood insulin;Metabolic traits;Triglyceride levels;Fasting plasma glucose;Urate levels in overweight individuals;Urate levels in obese individuals;Uric acid levels;Height;Age-related diseases, mortality and associated endophenotypes;Renal underexcretion gout;Fasting blood glucose (BMI interaction);Urate levels;Gondoic acid (20:1n-9) levels;Fasting blood insulin (BMI interaction);Triglycerides;Plasma omega-3 polyunsaturated fatty acid levels (docosapentaenoic acid);Type 2 diabetes;Nonalcoholic fatty liver disease;Hypertriglyceridemia;C-reactive protein;Age-related disease endophenotypes;LDL cholesterol;Metabolic syndrome;Crohn's disease;Alcohol consumption (drinks per week);Homeostasis model assessment of insulin resistance;Alcohol consumption;Red blood cell count;Fasting blood glucose; CRC cis rs9467711 0.606 rs2393667 chr6:26421345 T/C cg14345882 chr6:26364793 BTN3A2 0.7 5.75 0.3 2.03e-8 Autism spectrum disorder or schizophrenia; CRC cis rs9311474 0.581 rs4687626 chr3:52569098 G/A cg11645453 chr3:52864694 ITIH4 0.33 5.92 0.31 8.13e-9 Electroencephalogram traits; CRC cis rs7224737 1.000 rs731152 chr17:40279680 G/A cg02228675 chr17:40259724 DHX58 -0.5 -7.01 -0.36 1.38e-11 Fibrinogen levels; CRC cis rs9649465 0.967 rs12537989 chr7:123308195 A/G cg03229431 chr7:123269106 ASB15 -0.37 -5.76 -0.3 1.91e-8 Migraine; CRC cis rs6952808 0.636 rs6964522 chr7:1953523 C/T cg22963979 chr7:1858916 MAD1L1 -0.43 -6.85 -0.35 3.74e-11 Bipolar disorder and schizophrenia; CRC cis rs2277425 0.755 rs2277424 chr13:111522420 A/G cg03757805 chr13:111521981 C13orf29 -0.61 -7.59 -0.39 3.24e-13 Sitting height ratio; CRC cis rs35264875 0.950 rs72928659 chr11:68852358 C/T cg01993067 chr11:68851601 TPCN2 0.56 6.3 0.33 9.54e-10 Blond vs. brown hair color; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg17432135 chr20:43991688 SYS1;SYS1-DBNDD2 0.42 6.08 0.32 3.41e-9 Intelligence (multi-trait analysis); CRC cis rs4711350 0.765 rs756139 chr6:33755541 G/A cg07979401 chr6:33739406 LEMD2 -0.46 -5.98 -0.31 5.7e-9 Schizophrenia; CRC cis rs8072100 0.837 rs8070463 chr17:45768836 A/G cg08085267 chr17:45401833 C17orf57 -0.52 -7.92 -0.4 3.58e-14 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs4237845 0.537 rs2002275 chr12:58283385 A/G cg00677455 chr12:58241039 CTDSP2 0.82 12.05 0.55 6.03e-28 Intelligence (multi-trait analysis); CRC cis rs7927592 0.956 rs7944870 chr11:68309108 C/G cg01657329 chr11:68192670 LRP5 -0.48 -6.81 -0.35 4.71e-11 Total body bone mineral density; CRC cis rs2408955 0.521 rs1476607 chr12:48524804 A/G cg21466736 chr12:48725269 NA 0.51 7.7 0.39 1.61e-13 Glycated hemoglobin levels; CRC cis rs7773004 0.905 rs6932584 chr6:26327081 A/C cg13736514 chr6:26305472 NA -0.36 -6.17 -0.32 1.99e-9 Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for body mass index;Waist circumference adjusted for BMI in non-smokers;Waist circumference adjusted for BMI (adjusted for smoking behaviour); CRC cis rs3764563 1.000 rs2031061 chr19:15721961 T/C cg20725493 chr19:15740067 CYP4F8 -0.71 -6.54 -0.34 2.35e-10 Inflammatory biomarkers; CRC cis rs853679 0.542 rs9380063 chr6:28137853 A/G cg21251018 chr6:28226885 NKAPL 0.48 6.17 0.32 2.02e-9 Depression; CRC trans rs7937682 0.883 rs517982 chr11:111462687 T/C cg18187862 chr3:45730750 SACM1L 0.45 6.39 0.33 5.58e-10 Primary sclerosing cholangitis; CRC cis rs9926296 0.585 rs1800337 chr16:89845194 A/G cg03388025 chr16:89894329 SPIRE2 0.43 8.7 0.43 1.63e-16 Vitiligo; CRC cis rs1215050 0.791 rs6813619 chr4:98830768 C/T cg05340658 chr4:99064831 C4orf37 -0.47 -6.95 -0.36 2.01e-11 Waist-to-hip ratio adjusted for body mass index; CRC cis rs3733585 0.699 rs6844787 chr4:9959233 A/G cg11266682 chr4:10021025 SLC2A9 -0.47 -9.67 -0.47 1.2e-19 Cleft plate (environmental tobacco smoke interaction); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg19157971 chr1:202858393 RABIF 0.44 6.4 0.33 5.23e-10 Intelligence (multi-trait analysis); CRC cis rs875971 0.862 rs13232191 chr7:65986648 A/G cg00343986 chr7:65444356 GUSB 0.44 6.15 0.32 2.21e-9 Aortic root size; CRC cis rs2239547 0.522 rs2336162 chr3:52951519 C/T cg18404041 chr3:52824283 ITIH1 0.34 6.4 0.33 5.43e-10 Schizophrenia; CRC cis rs12900413 0.645 rs28407340 chr15:90311864 C/T cg24249390 chr15:90295951 MESP1 -0.58 -9.36 -0.46 1.28e-18 Coronary artery aneurysm in Kawasaki disease; CRC cis rs2204008 0.594 rs11531211 chr12:37998007 T/G cg13010199 chr12:38710504 ALG10B -0.49 -7.31 -0.37 1.98e-12 Bladder cancer; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg22917237 chr19:18633401 ELL 0.4 5.98 0.31 5.85e-9 Response to antipsychotic treatment; CRC cis rs736801 0.808 rs6866614 chr5:131787137 A/G cg00255919 chr5:131827918 IRF1 0.36 6.08 0.32 3.25e-9 Breast cancer;Mosquito bite size; CRC cis rs1218582 0.774 rs1007170 chr1:154881461 G/A cg03351412 chr1:154909251 PMVK 0.5 7.72 0.39 1.37e-13 Prostate cancer; CRC cis rs6693567 0.565 rs1260408 chr1:150307270 T/G cg04165759 chr1:150448943 RPRD2 0.36 5.84 0.31 1.22e-8 Migraine; CRC cis rs4728302 0.869 rs10255193 chr7:133608911 C/G cg03336402 chr7:133662267 EXOC4 -0.45 -6.54 -0.34 2.33e-10 Intelligence;Intelligence (multi-trait analysis); CRC cis rs595982 0.527 rs55706579 chr19:49382969 G/A cg15549821 chr19:49342101 PLEKHA4 -0.56 -6.26 -0.33 1.21e-9 Red cell distribution width; CRC cis rs2243480 1.000 rs35046236 chr7:65408613 T/C cg12463550 chr7:65579703 CRCP 0.62 5.95 0.31 6.68e-9 Diabetic kidney disease; CRC trans rs747782 0.528 rs11039669 chr11:48328818 C/T cg03929089 chr4:120376271 NA 0.67 6.42 0.33 4.68e-10 Intraocular pressure; CRC cis rs2836950 0.565 rs8134214 chr21:40542367 A/C cg17971929 chr21:40555470 PSMG1 -0.6 -8.77 -0.44 9.91e-17 Menarche (age at onset); CRC cis rs892961 1.000 rs2117924 chr17:75401310 C/T cg05865280 chr17:75406074 SEPT9 0.63 13.98 0.61 3.61e-35 Airflow obstruction; CRC cis rs7584330 0.910 rs880932 chr2:238396963 A/G cg14458575 chr2:238380390 NA 0.73 13.3 0.59 1.32e-32 Prostate cancer; CRC cis rs2404602 0.583 rs11072580 chr15:76540231 G/A cg26408565 chr15:76604113 ETFA -0.38 -5.9 -0.31 9.03e-9 Blood metabolite levels; CRC cis rs10512697 0.892 rs17636193 chr5:3540161 A/G cg19473799 chr5:3511975 NA 0.76 6.03 0.32 4.47e-9 Immune response to smallpox vaccine (IL-6); CRC cis rs4665809 1.000 rs1550381 chr2:26266946 A/G cg22920501 chr2:26401640 FAM59B -0.52 -7.11 -0.36 7.33e-12 Gut microbiome composition (summer); CRC cis rs2839186 0.588 rs7280110 chr21:47619039 G/A cg26721908 chr21:47610096 LSS 0.45 7.39 0.38 1.21e-12 Testicular germ cell tumor; CRC cis rs11190604 1.000 rs10883492 chr10:102206089 G/A cg07080220 chr10:102295463 HIF1AN 0.47 5.79 0.3 1.63e-8 Palmitoleic acid (16:1n-7) levels; CRC cis rs9640161 0.617 rs73170169 chr7:150008036 G/A cg13722127 chr7:150037890 RARRES2 0.49 7.59 0.39 3.25e-13 Blood protein levels;Circulating chemerin levels; CRC trans rs190945449 1 rs190945449 chr6:26828359 C/T cg06606381 chr12:133084897 FBRSL1 -1.01 -7.32 -0.37 1.97e-12 Urinary tract infection frequency; CRC cis rs62458065 0.850 rs62458099 chr7:32472395 C/T cg20159608 chr7:32802032 NA -0.55 -6.56 -0.34 2.11e-10 Metabolite levels (HVA/MHPG ratio); CRC cis rs9368481 0.594 rs2636425 chr6:26799460 A/G cg18278486 chr6:26987575 LOC100270746;C6orf41 0.38 6.02 0.32 4.62e-9 Autism spectrum disorder or schizophrenia; CRC cis rs2457480 0.602 rs17155641 chr10:44708346 A/G cg09554077 chr10:44749378 NA 0.51 6.64 0.34 1.27e-10 Coronary artery disease; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg11344692 chr8:61429175 RAB2A 0.44 6.51 0.34 2.73e-10 Intelligence (multi-trait analysis); CRC cis rs2243480 0.522 rs778717 chr7:65848151 G/C cg18252515 chr7:66147081 NA -1.15 -10.02 -0.48 8.37e-21 Diabetic kidney disease; CRC cis rs6479527 0.904 rs10122334 chr9:96864227 A/G cg14459158 chr9:96720562 NA 0.42 7.24 0.37 3.2e-12 Esophageal adenocarcinoma; CRC cis rs2836974 0.965 rs34578707 chr21:40675167 G/A cg06238570 chr21:40685208 BRWD1 0.75 10.33 0.49 7.45e-22 Cognitive function; CRC cis rs11148252 0.553 rs9536236 chr13:53255012 T/A cg00495681 chr13:53174319 NA 0.96 18.28 0.71 4.95e-52 Lewy body disease; CRC cis rs2404602 0.735 rs4886493 chr15:76679026 A/G cg23625390 chr15:77176239 SCAPER -0.83 -13.1 -0.59 7.4e-32 Blood metabolite levels; CRC cis rs208520 0.754 rs851594 chr6:66876695 A/G cg07460842 chr6:66804631 NA -1.05 -14.47 -0.62 4.53e-37 Exhaled nitric oxide output; CRC cis rs1799949 1.000 rs4793229 chr17:41418334 C/T cg19454999 chr17:41278357 BRCA1;NBR2 -0.52 -8.09 -0.41 1.15e-14 Menopause (age at onset); CRC cis rs3785574 0.582 rs62072238 chr17:61948841 A/T cg23090583 chr17:61904693 PSMC5;FTSJ3 0.6 8.61 0.43 3.05e-16 Height; CRC cis rs7586879 0.593 rs11689546 chr2:25130451 A/G cg04586622 chr2:25135609 ADCY3 -0.55 -10.26 -0.49 1.26e-21 Body mass index; CRC cis rs6502050 0.835 rs7212441 chr17:80080047 T/G cg13198984 chr17:80129470 CCDC57 -0.48 -8.58 -0.43 3.8e-16 Life satisfaction; CRC cis rs7177699 0.557 rs7403728 chr15:79112016 T/G cg15571903 chr15:79123663 NA -0.31 -6.06 -0.32 3.65e-9 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; CRC cis rs35110281 0.744 rs230645 chr21:44918607 A/G cg04455712 chr21:45112962 RRP1B -0.41 -7.67 -0.39 1.92e-13 Mean corpuscular volume; CRC cis rs769267 0.930 rs10402451 chr19:19608537 A/G cg01262667 chr19:19385393 TM6SF2 0.36 5.88 0.31 1e-8 Tonsillectomy; CRC trans rs10982213 0.830 rs2274163 chr9:117188714 C/T cg04080724 chr4:140202327 C4orf49 0.39 6.23 0.32 1.45e-9 Interleukin-6 levels; CRC cis rs548181 0.736 rs497344 chr11:125470524 T/C cg03464685 chr11:125439445 EI24 1.07 11.38 0.53 1.62e-25 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs2806561 0.765 rs1757046 chr1:23511821 T/C cg12483005 chr1:23474871 LUZP1 0.5 7.25 0.37 2.95e-12 Height; CRC cis rs7927771 0.965 rs4752881 chr11:47898535 A/G cg05585544 chr11:47624801 NA -0.61 -10.75 -0.51 2.7e-23 Subjective well-being; CRC trans rs7267979 1.000 rs2500443 chr20:25331442 C/T cg17903999 chr18:56338584 MALT1 0.43 6.98 0.36 1.59e-11 Liver enzyme levels (alkaline phosphatase); CRC cis rs56399783 0.901 rs73051469 chr7:2877811 A/G cg19731401 chr7:2775893 GNA12 0.6 6.32 0.33 8.44e-10 Childhood ear infection; CRC cis rs1801251 1.000 rs283475 chr2:233654381 A/C cg25237894 chr2:233734115 C2orf82 -0.51 -8.42 -0.42 1.15e-15 Coronary artery disease; CRC cis rs34375054 0.660 rs900411 chr12:125612839 C/T cg25124228 chr12:125621409 AACS -0.58 -8.44 -0.42 1.01e-15 Post bronchodilator FEV1/FVC ratio; CRC cis rs4843747 0.671 rs72818576 chr16:88111019 C/G cg17633681 chr16:88106987 BANP 0.85 15.69 0.65 8.33e-42 Menopause (age at onset); CRC cis rs172166 0.694 rs9295760 chr6:28147385 G/A cg10876282 chr6:28092338 ZSCAN16 0.5 6.67 0.35 1.05e-10 Cardiac Troponin-T levels; CRC cis rs7811142 1.000 rs66632384 chr7:100018904 G/A cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.97 13.45 0.6 3.81e-33 Platelet count; CRC cis rs3790645 1.000 rs282175 chr1:26895802 A/G cg23229016 chr1:26872525 RPS6KA1 0.3 7.02 0.36 1.24e-11 Glucose homeostasis traits; CRC cis rs1570884 0.740 rs12146924 chr13:50134358 T/C cg08779649 chr13:50194554 NA 0.31 5.99 0.31 5.41e-9 Sum basophil neutrophil counts;Sum neutrophil eosinophil counts;Neutrophil count;Myeloid white cell count;Granulocyte count; CRC cis rs10504229 0.683 rs72650839 chr8:58130029 C/T cg02290350 chr8:58132656 NA -0.58 -8.16 -0.41 7.29e-15 Developmental language disorder (linguistic errors); CRC cis rs9733 0.596 rs6587518 chr1:150661787 T/C cg15448220 chr1:150897856 SETDB1 0.45 6.45 0.34 3.93e-10 Tonsillectomy; CRC cis rs17376456 0.877 rs35747258 chr5:93310129 C/T cg21475434 chr5:93447410 FAM172A 0.77 7.8 0.4 8.13e-14 Diabetic retinopathy; CRC cis rs6912958 0.582 rs242285 chr6:88070743 G/A cg08069147 chr6:88032118 GJB7;C6orf162 0.74 11.83 0.55 3.96e-27 Monocyte percentage of white cells; CRC trans rs7873102 0.702 rs7028020 chr9:38007747 C/T cg16655837 chr10:32636197 EPC1 -0.4 -6.28 -0.33 1.09e-9 Brain structure; CRC cis rs9311474 0.508 rs11720159 chr3:52617802 T/G cg18099408 chr3:52552593 STAB1 -0.47 -8.06 -0.41 1.42e-14 Electroencephalogram traits; CRC cis rs11229555 0.645 rs4506677 chr11:58213852 T/C cg15696309 chr11:58395628 NA -0.82 -10.31 -0.49 8.59e-22 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; CRC cis rs1707322 0.721 rs56255771 chr1:46224319 C/T cg03146154 chr1:46216737 IPP 0.59 8.6 0.43 3.36e-16 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs8180040 0.966 rs6792461 chr3:47473168 C/T cg27129171 chr3:47204927 SETD2 -0.6 -9.27 -0.45 2.56e-18 Colorectal cancer; CRC cis rs853679 0.517 rs9393895 chr6:28127621 T/C cg21251018 chr6:28226885 NKAPL 0.48 6.28 0.33 1.06e-9 Depression; CRC cis rs1223397 0.938 rs35511719 chr6:13282442 T/C cg07912922 chr6:13274314 PHACTR1 0.53 6.47 0.34 3.49e-10 Blood pressure; CRC cis rs7493 1.000 rs1034809 chr7:95051652 G/A cg17330251 chr7:94953956 PON1 -0.58 -7.48 -0.38 7.01e-13 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs2462686 1.000 rs788765 chr7:45996985 C/G cg15898840 chr7:45960834 IGFBP3 -0.39 -5.96 -0.31 6.48e-9 Major depressive disorder; CRC cis rs7945705 0.837 rs10769981 chr11:9024460 T/C cg21881798 chr11:8931708 C11orf17;ST5 0.62 9.25 0.45 2.91e-18 Hemoglobin concentration; CRC cis rs798554 0.679 rs7784066 chr7:2819727 T/A cg19346786 chr7:2764209 NA -0.4 -7.37 -0.38 1.42e-12 Height; CRC cis rs11098499 0.955 rs1551 chr4:120158500 T/G cg24375607 chr4:120327624 NA 0.43 6.78 0.35 5.71e-11 Corneal astigmatism; CRC cis rs1862618 0.853 rs252909 chr5:56121131 T/C cg22800045 chr5:56110881 MAP3K1 0.56 6.2 0.32 1.69e-9 Initial pursuit acceleration; CRC cis rs1401999 1.000 rs939338 chr3:183704068 A/G cg20387954 chr3:183756860 HTR3D -0.44 -7.58 -0.39 3.59e-13 Anterior chamber depth; CRC cis rs1728785 0.818 rs1728772 chr16:68584526 C/T cg02972257 chr16:68554789 NA -0.58 -7.24 -0.37 3.21e-12 Ulcerative colitis; CRC cis rs9768139 0.935 rs7782393 chr7:158120486 G/A cg24154853 chr7:158122151 PTPRN2 -0.59 -9.91 -0.48 2.03e-20 Calcium levels; CRC cis rs3785574 0.927 rs2854160 chr17:61977248 C/T cg25654072 chr17:61904446 PSMC5;FTSJ3 0.43 5.76 0.3 1.94e-8 Height; CRC cis rs35520189 0.591 rs6723197 chr2:113701598 T/G cg12858261 chr2:113808755 IL1F8 0.49 6.87 0.35 3.29e-11 Obstructive sleep apnea trait (apnea hypopnea index); CRC cis rs6684514 0.961 rs10908503 chr1:156300683 C/T cg16558208 chr1:156270281 VHLL 0.56 8.76 0.43 1.06e-16 Mean corpuscular hemoglobin concentration;Glycated hemoglobin levels; CRC trans rs800082 0.690 rs2575191 chr3:144279228 G/A cg24215973 chr2:240111563 HDAC4 0.57 8.94 0.44 2.81e-17 Smoking behavior; CRC cis rs875971 0.545 rs73152714 chr7:65999628 G/A cg18876405 chr7:65276391 NA 0.44 6.19 0.32 1.82e-9 Aortic root size; CRC cis rs2032447 1.000 rs2032447 chr6:26044369 A/G cg04800585 chr6:26043546 HIST1H2BB 0.53 8.24 0.41 4.14e-15 Intelligence (multi-trait analysis); CRC cis rs34172651 0.917 rs200529 chr16:24758502 T/C cg00339695 chr16:24857497 SLC5A11 -0.28 -6.63 -0.34 1.4e-10 Intelligence (multi-trait analysis); CRC cis rs9649213 0.593 rs36017146 chr7:97974617 C/T cg24562669 chr7:97807699 LMTK2 0.44 7.39 0.38 1.18e-12 Prostate cancer (SNP x SNP interaction); CRC cis rs9925964 0.935 rs12597511 chr16:31145219 C/T cg03418659 chr16:31128414 MYST1 0.55 7.97 0.4 2.7e-14 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs7618915 0.547 rs34610878 chr3:52759169 G/C cg05573699 chr3:52720067 GNL3;PBRM1 -0.47 -6.68 -0.35 1.03e-10 Bipolar disorder; CRC cis rs4660306 0.961 rs4660868 chr1:45986497 A/G cg03123370 chr1:45965343 CCDC163P;MMACHC -0.55 -7.81 -0.4 7.94e-14 Homocysteine levels; CRC cis rs2842992 0.789 rs9355748 chr6:160194882 G/A cg19482086 chr6:160211437 TCP1;MRPL18 0.73 9.66 0.47 1.39e-19 Age-related macular degeneration (geographic atrophy); CRC cis rs10484885 0.878 rs1328018 chr6:90297847 A/G cg13799429 chr6:90582589 CASP8AP2 0.73 7.77 0.39 9.97e-14 QRS interval (sulfonylurea treatment interaction); CRC cis rs10911390 0.744 rs115862617 chr1:183652656 A/T cg11505048 chr1:183622726 RGL1;APOBEC4 0.71 6.24 0.33 1.33e-9 Systemic lupus erythematosus; CRC cis rs7727544 0.716 rs10058655 chr5:131570896 A/T cg02033258 chr5:131593261 PDLIM4 0.36 6.77 0.35 5.75e-11 Blood metabolite levels; CRC cis rs881375 0.967 rs1008382 chr9:123681255 C/G cg09586646 chr9:123605570 PSMD5;LOC253039 0.52 7.18 0.37 4.81e-12 Rheumatoid arthritis; CRC cis rs7666738 0.830 rs969049 chr4:98988857 C/T cg17366294 chr4:99064904 C4orf37 0.43 7.25 0.37 2.91e-12 Colonoscopy-negative controls vs population controls; CRC cis rs6088813 1.000 rs6142376 chr20:33992761 T/A cg14752227 chr20:34000481 UQCC -0.37 -5.74 -0.3 2.12e-8 Height; CRC cis rs863345 0.564 rs11265014 chr1:158503221 T/C cg12129480 chr1:158549410 OR10X1 -0.3 -6.28 -0.33 1.09e-9 Pneumococcal bacteremia; CRC cis rs17376456 0.877 rs12716457 chr5:93397627 T/C cg09848695 chr5:92956644 FAM172A;MIR2277 0.61 5.68 0.3 2.95e-8 Diabetic retinopathy; CRC trans rs2795502 0.882 rs3123754 chr10:43339011 G/A cg06791473 chr12:49259579 RND1 0.61 6.03 0.32 4.5e-9 Blood protein levels; CRC cis rs10883723 0.810 rs7072351 chr10:104265047 C/T cg04362960 chr10:104952993 NT5C2 -0.43 -5.95 -0.31 6.88e-9 Allergic disease (asthma, hay fever or eczema); CRC trans rs3749237 0.964 rs1799845 chr3:49847623 A/G cg21665057 chr3:196295764 WDR53;FBXO45 0.51 6.91 0.36 2.53e-11 Resting heart rate; CRC cis rs11212617 0.967 rs4585 chr11:108239628 G/T cg12106634 chr11:108092400 ATM;NPAT 0.44 6.64 0.34 1.27e-10 Response to metformin in type 2 diabetes (glycemic); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg21790971 chr4:54244117 FIP1L1 0.49 6.97 0.36 1.79e-11 Response to antipsychotic treatment; CRC cis rs6582630 0.502 rs11520276 chr12:38359216 C/T cg13010199 chr12:38710504 ALG10B 0.46 6.27 0.33 1.14e-9 Drug-induced liver injury (flucloxacillin); CRC cis rs28386778 0.797 rs4968664 chr17:61851366 C/G cg23090583 chr17:61904693 PSMC5;FTSJ3 1.04 20.53 0.75 6.95e-61 Prudent dietary pattern; CRC cis rs6502050 0.736 rs11658040 chr17:80059891 C/T cg25804541 chr17:80189381 SLC16A3 0.32 5.99 0.31 5.64e-9 Life satisfaction; CRC cis rs1614887 1 rs1614887 chr6:26393021 A/G cg09904177 chr6:26538194 HMGN4 0.56 7.77 0.39 1.04e-13 Intelligence (multi-trait analysis);Lobe attachment (rater-scored or self-reported); CRC cis rs933688 1.000 rs6867219 chr5:90718008 T/G cg02339078 chr5:90679543 LOC100129716;ARRDC3 0.92 13.87 0.61 9.28e-35 Smoking behavior; CRC cis rs847577 0.651 rs10464490 chr7:97715319 T/G cg00277769 chr7:97922759 BAIAP2L1 -0.4 -6.78 -0.35 5.43e-11 Breast cancer; CRC cis rs9768139 0.708 rs896780 chr7:158113972 C/T cg06219351 chr7:158114137 PTPRN2 -0.58 -9.19 -0.45 4.71e-18 Calcium levels; CRC cis rs2153535 0.580 rs6597322 chr6:8449952 T/G cg07606381 chr6:8435919 SLC35B3 0.68 10.85 0.51 1.22e-23 Motion sickness; CRC cis rs10504073 0.647 rs341807 chr8:50032676 C/T cg00325661 chr8:49890786 NA 0.46 8.23 0.41 4.37e-15 Blood metabolite ratios; CRC cis rs847577 0.748 rs940432 chr7:97716483 G/A cg21770322 chr7:97807741 LMTK2 0.84 18.44 0.71 1.18e-52 Breast cancer; CRC cis rs875971 1.000 rs1144894 chr7:65542894 A/G cg00343986 chr7:65444356 GUSB -0.47 -6.94 -0.36 2.05e-11 Aortic root size; CRC cis rs7107174 1.000 rs731600 chr11:77963133 A/G cg02023728 chr11:77925099 USP35 0.48 8.34 0.42 2.03e-15 Testicular germ cell tumor; CRC cis rs79976124 0.842 rs7760550 chr6:66628788 T/C cg07460842 chr6:66804631 NA 0.72 8.92 0.44 3.26e-17 Type 2 diabetes; CRC cis rs3931020 0.548 rs969435 chr1:75273866 A/G cg00121533 chr1:75199117 CRYZ;TYW3 -0.54 -6.86 -0.35 3.42e-11 Resistin levels; CRC trans rs6598955 0.671 rs12089149 chr1:26638500 C/A cg07461501 chr17:79650226 HGS;ARL16 -0.55 -6.45 -0.34 4.03e-10 Obesity-related traits; CRC cis rs72772090 0.539 rs72775807 chr5:96179761 C/T cg17330273 chr5:96107758 CAST;ERAP1 -0.58 -5.72 -0.3 2.46e-8 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs2795502 0.882 rs2744093 chr10:43339243 A/G cg27426351 chr10:43362370 NA -0.6 -7.12 -0.37 6.96e-12 Blood protein levels; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg01353569 chr7:106810328 HBP1 0.53 7.67 0.39 1.94e-13 Response to antipsychotic treatment; CRC cis rs9381040 0.537 rs9462669 chr6:41013659 C/A cg09580153 chr6:41068724 NFYA;LOC221442 -0.42 -6.1 -0.32 2.98e-9 Alzheimer's disease (late onset); CRC cis rs3820068 0.532 rs72645862 chr1:15920366 A/G cg27534772 chr1:16042836 PLEKHM2 0.53 10.04 0.48 7.27e-21 Systolic blood pressure; CRC trans rs1656966 1.000 rs1656966 chr3:186466252 C/T cg12241367 chr10:13203349 MCM10 0.42 6.21 0.32 1.59e-9 Myopia (pathological); CRC cis rs1983170 1.000 rs12563578 chr1:91993702 T/C cg02896835 chr1:92012615 NA 0.48 6.31 0.33 9.19e-10 Eosinophil percentage of white cells; CRC cis rs4757319 0.532 rs4456244 chr11:15439353 T/C cg03245590 chr11:15329459 NA 0.42 7.27 0.37 2.62e-12 Breast cancer; CRC cis rs7811142 1.000 rs6979335 chr7:100089860 T/C cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.16 16.12 0.66 1.72e-43 Platelet count; CRC cis rs4713118 0.869 rs9348775 chr6:27695329 C/T cg25164649 chr6:28176230 NA 0.57 7.98 0.4 2.44e-14 Parkinson's disease; CRC cis rs2228479 0.850 rs62054609 chr16:89816569 C/A cg06656553 chr16:89960601 TCF25 -0.69 -5.74 -0.3 2.15e-8 Skin colour saturation; CRC cis rs4523957 0.890 rs6503324 chr17:2100512 C/T cg16513277 chr17:2031491 SMG6 -0.52 -8.92 -0.44 3.24e-17 Autism spectrum disorder or schizophrenia;Schizophrenia; CRC cis rs2243480 0.708 rs781141 chr7:65438553 A/G cg12463550 chr7:65579703 CRCP 0.62 5.97 0.31 6.09e-9 Diabetic kidney disease; CRC cis rs6502050 0.835 rs8078087 chr17:80113322 T/G cg11859384 chr17:80120422 CCDC57 -0.37 -5.85 -0.31 1.16e-8 Life satisfaction; CRC cis rs6502050 0.528 rs12942561 chr17:80116639 G/A cg09264619 chr17:80180166 NA -0.34 -5.71 -0.3 2.52e-8 Life satisfaction; CRC cis rs34375054 0.573 rs12831151 chr12:125656263 C/T cg02766259 chr12:125626809 AACS -0.42 -6.16 -0.32 2.13e-9 Post bronchodilator FEV1/FVC ratio; CRC cis rs977987 0.806 rs7204984 chr16:75475520 G/C cg03315344 chr16:75512273 CHST6 0.55 9.35 0.46 1.39e-18 Dupuytren's disease; CRC cis rs3806843 1.000 rs13184940 chr5:140172918 T/C cg19875535 chr5:140030758 IK 0.6 9.84 0.48 3.35e-20 Depressive symptoms (multi-trait analysis); CRC cis rs904251 0.600 rs4714068 chr6:37455642 A/C cg01843034 chr6:37503916 NA -0.34 -6.0 -0.31 5.34e-9 Cognitive performance; CRC cis rs929354 1.000 rs1182381 chr7:157043473 G/A cg17757837 chr7:157058334 UBE3C -0.81 -14.77 -0.63 3.3e-38 Body mass index; CRC cis rs2832191 0.716 rs8132085 chr21:30501389 G/T cg24692254 chr21:30365293 RNF160 -0.81 -14.08 -0.61 1.49e-35 Dental caries; CRC cis rs911555 0.692 rs7140647 chr14:103893465 A/G cg24130564 chr14:104152367 KLC1 0.44 5.91 0.31 8.56e-9 Intelligence (multi-trait analysis); CRC cis rs4728302 0.869 rs12707129 chr7:133593177 A/G cg10665199 chr7:133106180 EXOC4 0.39 5.84 0.31 1.25e-8 Intelligence;Intelligence (multi-trait analysis); CRC cis rs7236492 0.572 rs78124041 chr18:77181489 G/A cg15644404 chr18:77186268 NFATC1 -0.8 -6.6 -0.34 1.62e-10 Inflammatory bowel disease;Crohn's disease; CRC trans rs12517041 0.935 rs10062553 chr5:23294800 G/A ch.8.1293020R chr8:59333349 UBXN2B -0.55 -6.17 -0.32 2.05e-9 Calcium levels; CRC cis rs853679 0.517 rs9368554 chr6:28082711 T/C cg18032046 chr6:28092343 ZSCAN16 -0.52 -6.02 -0.31 4.76e-9 Depression; CRC cis rs9467711 0.790 rs35162296 chr6:26318262 C/T cg08501292 chr6:25962987 TRIM38 0.84 6.06 0.32 3.63e-9 Autism spectrum disorder or schizophrenia; CRC cis rs7113874 0.589 rs2044463 chr11:8463951 G/A cg17679104 chr11:8615758 STK33 -0.34 -5.63 -0.3 3.78e-8 Body mass index in physically active individuals;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs10484885 0.824 rs72921954 chr6:90586656 A/G cg13799429 chr6:90582589 CASP8AP2 -0.74 -7.81 -0.4 7.97e-14 QRS interval (sulfonylurea treatment interaction); CRC cis rs477895 0.713 rs35095324 chr11:63948412 G/A cg18225595 chr11:63971243 STIP1 0.61 8.05 0.41 1.55e-14 Mean platelet volume; CRC trans rs66573146 1.000 rs59683609 chr4:6964910 C/G cg07817883 chr1:32538562 TMEM39B 1.51 13.3 0.59 1.33e-32 Granulocyte percentage of myeloid white cells; CRC cis rs10791323 0.546 rs55801927 chr11:133713094 A/C cg03690763 chr11:133734501 NA -0.34 -5.78 -0.3 1.71e-8 Childhood ear infection; CRC cis rs2108622 0.683 rs56228205 chr19:15981973 A/C cg13772218 chr19:15982569 NA 0.48 6.81 0.35 4.52e-11 Circulating phylloquinone levels;Vitamin E levels;Acenocoumarol maintenance dosage;Response to Vitamin E supplementation;Metabolite levels;Warfarin maintenance dose; CRC cis rs9910055 0.762 rs11080007 chr17:42265442 A/G cg13607699 chr17:42295918 UBTF -0.5 -6.66 -0.34 1.13e-10 Total body bone mineral density; CRC cis rs919433 0.713 rs6719483 chr2:198472886 A/G cg10820045 chr2:198174542 NA 0.42 7.3 0.37 2.12e-12 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC cis rs7208859 0.623 rs59029591 chr17:29235746 A/C cg01831904 chr17:28903510 LRRC37B2 -0.56 -5.83 -0.31 1.35e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC trans rs1005277 0.579 rs1780146 chr10:38517874 C/A cg23533926 chr12:111358616 MYL2 -0.55 -8.38 -0.42 1.6e-15 Extrinsic epigenetic age acceleration; CRC cis rs11677370 0.603 rs10164826 chr2:3849951 G/C cg17052675 chr2:3827356 NA -0.65 -10.65 -0.51 6.06e-23 Type 2 diabetes; CRC cis rs4727027 0.933 rs12704063 chr7:148827909 T/C cg12479418 chr7:148823350 ZNF425;ZNF398 0.44 5.88 0.31 1e-8 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg07902188 chr19:30097207 POP4 0.46 6.48 0.34 3.37e-10 Anxiety disorder; CRC cis rs9911578 0.835 rs1476596 chr17:56485358 C/T cg12560992 chr17:57184187 TRIM37 0.83 14.42 0.62 7.25e-37 Intelligence (multi-trait analysis); CRC trans rs885518 0.852 rs1440992 chr9:21778711 T/C cg14925137 chr3:121554019 IQCB1;EAF2 0.55 6.08 0.32 3.31e-9 Lung adenocarcinoma; CRC cis rs694739 0.964 rs2510066 chr11:64052447 C/T cg23796481 chr11:64053134 BAD;GPR137 0.59 8.73 0.43 1.3e-16 Alopecia areata;Crohn's disease;Psoriasis vulgaris; CRC cis rs1799949 1.000 rs16942 chr17:41244000 T/C cg19454999 chr17:41278357 BRCA1;NBR2 0.56 8.72 0.43 1.37e-16 Menopause (age at onset); CRC cis rs2976388 0.609 rs2244152 chr8:143784885 C/A cg12516270 chr8:143859308 LYNX1 0.44 7.73 0.39 1.34e-13 Urinary tract infection frequency; CRC cis rs10979 0.965 rs9403508 chr6:143887857 G/A cg25407410 chr6:143891975 LOC285740 -0.82 -13.41 -0.59 5.06e-33 Hypospadias; CRC cis rs4819052 0.851 rs1056099 chr21:46678892 G/A cg19498844 chr21:46707878 POFUT2;LOC642852 0.71 10.17 0.49 2.6e-21 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs2179367 0.959 rs2262617 chr6:149759726 C/G cg11245181 chr6:149772854 ZC3H12D -0.42 -6.49 -0.34 3.14e-10 Dupuytren's disease; CRC cis rs9487051 0.676 rs6928622 chr6:109595112 C/T cg12927641 chr6:109611667 NA -0.36 -6.44 -0.33 4.15e-10 Reticulocyte fraction of red cells; CRC trans rs10983614 1.000 rs7867776 chr9:120072627 A/G cg15604682 chr7:102105781 ALKBH4;LRWD1 0.45 6.16 0.32 2.13e-9 Survival in pancreatic cancer; CRC cis rs4713118 0.869 rs6456802 chr6:27698355 A/G cg15786705 chr6:28176104 NA 0.54 7.62 0.39 2.72e-13 Parkinson's disease; CRC cis rs12368653 0.591 rs1038914 chr12:58011066 G/A cg00677455 chr12:58241039 CTDSP2 0.39 5.69 0.3 2.85e-8 Multiple sclerosis; CRC cis rs9302635 0.513 rs8044555 chr16:72152755 T/C cg23815491 chr16:72088622 HP 0.65 8.31 0.42 2.53e-15 Blood protein levels; CRC cis rs10779751 0.770 rs2258621 chr1:11141187 C/G cg08854313 chr1:11322531 MTOR 0.57 7.45 0.38 8.12e-13 Body mass index; CRC cis rs55823223 0.503 rs55699990 chr17:73859186 A/G cg14829360 chr17:73884958 NA -0.43 -6.67 -0.34 1.11e-10 Psoriasis; CRC cis rs2949837 0.581 rs1496499 chr7:45979023 T/G cg15898840 chr7:45960834 IGFBP3 0.46 7.61 0.39 2.93e-13 Sitting height ratio; CRC cis rs6429082 0.818 rs291340 chr1:235674379 C/T cg26050004 chr1:235667680 B3GALNT2 0.58 7.9 0.4 4.31e-14 Adiposity; CRC cis rs67311347 0.955 rs4974068 chr3:40376929 T/C cg09455208 chr3:40491958 NA 0.43 8.68 0.43 1.84e-16 Renal cell carcinoma; CRC cis rs17826219 0.568 rs59858012 chr17:29078582 C/T cg13385521 chr17:29058706 SUZ12P 0.71 7.15 0.37 5.57e-12 Body mass index; CRC cis rs11252926 0.624 rs7085214 chr10:468133 A/G cg18196295 chr10:418757 DIP2C 0.56 8.67 0.43 2.04e-16 Psychosis in Alzheimer's disease; CRC cis rs7811142 1.000 rs11769700 chr7:100090049 T/C cg00814883 chr7:100076585 TSC22D4 -0.74 -9.36 -0.46 1.31e-18 Platelet count; CRC cis rs1799949 1.000 rs3950989 chr17:41237953 G/A cg01879757 chr17:41196368 BRCA1 -0.42 -6.32 -0.33 8.39e-10 Menopause (age at onset); CRC cis rs853679 0.517 rs9393885 chr6:28050009 A/T cg02631126 chr6:28058918 ZSCAN12L1 0.29 5.95 0.31 7.04e-9 Depression; CRC cis rs6951245 0.935 rs113365567 chr7:1108785 T/C cg03188948 chr7:1209495 NA 0.66 6.86 0.35 3.35e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs4862750 0.915 rs6835681 chr4:187903476 A/G cg06074448 chr4:187884817 NA -0.58 -10.57 -0.5 1.11e-22 Lobe attachment (rater-scored or self-reported); CRC cis rs2688482 0.557 rs3103952 chr3:195522690 T/C cg05834845 chr3:195489306 MUC4 0.67 7.24 0.37 3.14e-12 Lung disease severity in cystic fibrosis; CRC cis rs9549367 0.789 rs6577031 chr13:113878182 T/C cg24300038 chr13:113819356 PROZ 0.45 6.08 0.32 3.39e-9 Platelet distribution width; CRC trans rs7618501 0.699 rs1317154 chr3:49910084 T/C cg21665057 chr3:196295764 WDR53;FBXO45 0.66 10.45 0.5 2.91e-22 Intelligence (multi-trait analysis); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg09726240 chr11:70672878 SHANK2 0.27 6.26 0.33 1.17e-9 Liver disease severity in Alagille syndrome; CRC cis rs921968 0.544 rs58827325 chr2:219415166 A/T cg02176678 chr2:219576539 TTLL4 0.53 8.6 0.43 3.29e-16 Mean corpuscular hemoglobin concentration; CRC cis rs4253772 0.591 rs6008365 chr22:46652929 G/A cg24881330 chr22:46731750 TRMU 0.56 6.66 0.34 1.12e-10 LDL cholesterol;Cholesterol, total; CRC cis rs12900413 0.687 rs28653538 chr15:90304964 T/C cg24249390 chr15:90295951 MESP1 -0.56 -8.69 -0.43 1.71e-16 Coronary artery aneurysm in Kawasaki disease; CRC cis rs853679 0.546 rs200989 chr6:27816442 A/G cg03623178 chr6:28175578 NA 0.77 6.63 0.34 1.42e-10 Depression; CRC cis rs838147 0.563 rs281379 chr19:49214274 C/T cg21064579 chr19:49206444 FUT2 0.43 6.93 0.36 2.19e-11 Dietary macronutrient intake; CRC cis rs1949733 0.701 rs2631735 chr4:8476118 A/G cg13073564 chr4:8508604 NA -0.47 -7.05 -0.36 1.03e-11 Response to antineoplastic agents; CRC cis rs7727544 0.716 rs72793283 chr5:131566941 G/A cg09877947 chr5:131593287 PDLIM4 0.36 6.51 0.34 2.82e-10 Blood metabolite levels; CRC cis rs1005277 0.579 rs2505248 chr10:38459097 A/G cg25517755 chr10:38738941 LOC399744 -0.43 -6.12 -0.32 2.64e-9 Extrinsic epigenetic age acceleration; CRC cis rs2154427 0.511 rs7279487 chr21:34001824 T/C cg21871883 chr21:34145043 C21orf49;C21orf66 0.6 7.1 0.36 7.91e-12 Bilirubin levels; CRC cis rs6679356 0.789 rs3790566 chr1:67814440 T/C cg24364144 chr1:67875067 SERBP1 0.43 6.55 0.34 2.17e-10 Primary biliary cholangitis; CRC cis rs4722166 0.630 rs13311155 chr7:22789789 A/C cg05472934 chr7:22766657 IL6 0.77 12.59 0.57 5.91e-30 Lung cancer; CRC cis rs13108904 0.934 rs13134106 chr4:1302902 A/G cg00684032 chr4:1343700 KIAA1530 0.44 6.38 0.33 6.11e-10 Obesity-related traits; CRC cis rs60871478 0.786 rs62432898 chr7:826102 G/A cg13844804 chr7:814759 HEATR2 0.68 8.0 0.4 2.15e-14 Cerebrospinal P-tau181p levels; CRC cis rs9914988 0.887 rs12947735 chr17:27156866 A/T cg07195577 chr17:27052828 TLCD1 0.42 6.07 0.32 3.45e-9 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs13191362 1.000 rs13192894 chr6:163052444 T/A cg23758597 chr6:163146217 PARK2 -0.68 -6.78 -0.35 5.72e-11 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs459571 0.839 rs10993895 chr9:136887726 C/T cg13789015 chr9:136890014 NCRNA00094 -0.43 -5.82 -0.31 1.43e-8 Platelet distribution width; CRC cis rs11122272 0.735 rs2474625 chr1:231519331 A/G cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.54 -8.09 -0.41 1.18e-14 Hemoglobin concentration; CRC cis rs1552244 0.935 rs2272124 chr3:10138189 T/C cg10729496 chr3:10149963 C3orf24 0.49 6.81 0.35 4.72e-11 Alzheimer's disease; CRC cis rs12926788 0.640 rs12924246 chr16:24844629 A/G cg04756594 chr16:24857601 SLC5A11 0.3 6.25 0.33 1.27e-9 Ejection fraction in Tripanosoma cruzi seropositivity; CRC cis rs875971 0.798 rs57739047 chr7:65972566 A/T cg11764359 chr7:65958608 NA 0.61 9.52 0.46 3.78e-19 Aortic root size; CRC cis rs853679 0.517 rs4711165 chr6:28115184 T/G cg25164649 chr6:28176230 NA 0.78 9.66 0.47 1.33e-19 Depression; CRC cis rs10779751 1.000 rs12730522 chr1:11284091 G/A cg08854313 chr1:11322531 MTOR 0.77 12.02 0.55 7.44e-28 Body mass index; CRC cis rs12594515 1.000 rs8032835 chr15:45997897 C/G cg22117107 chr15:45993392 NA -0.43 -8.67 -0.43 2.02e-16 Waist circumference;Weight; CRC cis rs13108904 0.935 rs11247984 chr4:1292811 G/A cg02018176 chr4:1364513 KIAA1530 0.47 7.7 0.39 1.56e-13 Obesity-related traits; CRC cis rs798554 0.642 rs2533871 chr7:2883006 C/G cg04166393 chr7:2884313 GNA12 0.55 7.47 0.38 7.52e-13 Height; CRC cis rs4713118 0.662 rs9468277 chr6:28028390 C/A cg03623178 chr6:28175578 NA 0.92 12.95 0.58 2.82e-31 Parkinson's disease; CRC trans rs4621152 1.000 rs4621152 chr2:217908985 C/T cg03559682 chr11:6439864 APBB1 0.31 6.06 0.32 3.76e-9 Gut microbiota (bacterial taxa); CRC cis rs4862750 0.914 rs1346126 chr4:187876404 T/C cg10295955 chr4:187884368 NA -1.01 -24.02 -0.8 2.33e-74 Lobe attachment (rater-scored or self-reported); CRC cis rs66573146 0.572 rs55740475 chr4:6954092 C/G cg00086871 chr4:6988644 TBC1D14 0.91 8.68 0.43 1.8e-16 Granulocyte percentage of myeloid white cells; CRC cis rs919433 0.889 rs10931782 chr2:198211579 G/A cg10820045 chr2:198174542 NA -0.5 -8.23 -0.41 4.5e-15 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC trans rs2303319 0.504 rs55925603 chr2:162497210 G/A cg23247704 chr1:116518985 SLC22A15 -0.7 -6.04 -0.32 4.14e-9 Cognitive function; CRC trans rs1656966 1.000 rs1656966 chr3:186466252 C/T cg22197824 chr11:65431114 RELA 0.4 6.09 0.32 3.16e-9 Myopia (pathological); CRC cis rs11997175 0.646 rs4463379 chr8:33692719 G/A ch.8.33884649F chr8:33765107 NA 0.46 6.6 0.34 1.68e-10 Body mass index; CRC cis rs13191362 1.000 rs13201023 chr6:162981381 C/G cg06582575 chr6:163149167 PACRG;PARK2 0.82 11.45 0.53 8.87e-26 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs9733 0.596 rs6692960 chr1:150695965 G/A cg18016565 chr1:150552671 MCL1 0.45 6.52 0.34 2.57e-10 Tonsillectomy; CRC cis rs2836974 0.829 rs8128191 chr21:40527311 A/G cg06238570 chr21:40685208 BRWD1 0.71 10.1 0.49 4.5e-21 Cognitive function; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg12588638 chr12:83080208 TMTC2 0.41 6.12 0.32 2.64e-9 Intelligence (multi-trait analysis); CRC cis rs9311474 0.508 rs7614498 chr3:52618941 A/T cg18404041 chr3:52824283 ITIH1 -0.4 -8.45 -0.42 9.48e-16 Electroencephalogram traits; CRC trans rs10838798 0.504 rs11039530 chr11:48145746 C/T cg15704280 chr7:45808275 SEPT13 -0.46 -6.53 -0.34 2.53e-10 Height; CRC cis rs533581 0.866 rs475796 chr16:88970776 C/G cg09141835 chr16:88988174 CBFA2T3 -0.29 -6.17 -0.32 1.95e-9 Social autistic-like traits; CRC cis rs477692 0.569 rs10764886 chr10:131310680 C/T cg05714579 chr10:131428358 MGMT 0.54 7.72 0.39 1.43e-13 Response to temozolomide; CRC cis rs7665939 0.860 rs61745583 chr4:190125993 A/G cg09826759 chr4:190284978 NA -0.65 -5.64 -0.3 3.58e-8 Amyotrophic lateral sclerosis; CRC cis rs4665809 0.590 rs35727620 chr2:26458364 G/A cg26119090 chr2:26468346 HADHA;HADHB 1.06 15.5 0.65 4.69e-41 Gut microbiome composition (summer); CRC cis rs8180040 0.767 rs11920853 chr3:47308183 G/A cg02527881 chr3:46936655 PTH1R 0.36 6.19 0.32 1.75e-9 Colorectal cancer; CRC cis rs524023 0.914 rs7932437 chr11:64373504 T/C cg06522879 chr11:64358276 SLC22A12 -0.54 -8.37 -0.42 1.66e-15 Urate levels in obese individuals; CRC cis rs55871839 0.684 rs6988143 chr8:59810572 C/T cg07426533 chr8:59803705 TOX -0.34 -5.94 -0.31 7.22e-9 Pneumonia; CRC cis rs17253792 0.915 rs28663681 chr14:56178820 A/T cg01858014 chr14:56050164 KTN1 -0.81 -6.11 -0.32 2.87e-9 Putamen volume; CRC cis rs4629710 0.545 rs11154621 chr6:131547341 A/G cg12606694 chr6:131520996 AKAP7 0.54 8.26 0.41 3.59e-15 Multiple myeloma (IgH translocation); CRC cis rs7617480 0.648 rs6796790 chr3:48780317 G/A cg07636037 chr3:49044803 WDR6 0.85 11.43 0.53 1.05e-25 Subjective well-being (multi-trait analysis);Menarche (age at onset); CRC cis rs773506 0.628 rs10820836 chr9:93928329 A/G cg14446406 chr9:93919335 NA -0.44 -7.61 -0.39 2.91e-13 Type 2 diabetes nephropathy; CRC trans rs2303319 0.504 rs12467613 chr2:162603216 G/T cg25193742 chr10:104614220 C10orf32 -0.77 -6.51 -0.34 2.87e-10 Cognitive function; CRC cis rs896854 0.812 rs4582532 chr8:95969257 G/A cg13393036 chr8:95962371 TP53INP1 -0.53 -9.02 -0.45 1.64e-17 Type 2 diabetes; CRC cis rs4132509 1.000 rs73128287 chr1:243952150 T/G cg21452805 chr1:244014465 NA 0.51 6.92 0.36 2.44e-11 RR interval (heart rate); CRC cis rs7809950 0.954 rs12673675 chr7:107113220 T/C cg23024343 chr7:107201750 COG5 -0.61 -8.68 -0.43 1.88e-16 Coronary artery disease; CRC cis rs2046867 0.818 rs6792109 chr3:72867091 C/T cg25664220 chr3:72788482 NA -0.44 -6.43 -0.33 4.44e-10 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; CRC cis rs2404618 0.506 rs12156177 chr8:1493684 C/T cg13402656 chr8:1511478 DLGAP2 -0.53 -8.82 -0.44 6.65e-17 Lung cancer; CRC cis rs17331151 0.541 rs1139106 chr3:52871101 G/A cg06204229 chr3:52865917 ITIH4 0.58 7.97 0.4 2.71e-14 Immune reponse to smallpox (secreted IL-2); CRC cis rs6460942 0.908 rs78374554 chr7:12242285 G/A cg06484146 chr7:12443880 VWDE -0.67 -6.52 -0.34 2.7e-10 Coronary artery disease; CRC cis rs394563 1.000 rs394563 chr6:149797014 T/G cg07828024 chr6:149772892 ZC3H12D -0.47 -8.27 -0.41 3.37e-15 Dupuytren's disease; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg02257712 chr5:150080478 RBM22 0.46 6.4 0.33 5.44e-10 Response to antipsychotic treatment; CRC cis rs2576037 0.901 rs2060416 chr18:44576240 G/C cg19077165 chr18:44547161 KATNAL2 0.48 7.59 0.39 3.41e-13 Personality dimensions; CRC cis rs6460942 0.505 rs73055515 chr7:12328804 A/G cg06484146 chr7:12443880 VWDE -0.63 -6.66 -0.34 1.13e-10 Coronary artery disease; CRC cis rs9796 0.866 rs2928148 chr15:41401550 G/A cg18705301 chr15:41695430 NDUFAF1 0.34 5.64 0.3 3.71e-8 Menopause (age at onset); CRC cis rs7772486 0.720 rs7752286 chr6:146072662 C/T cg13319975 chr6:146136371 FBXO30 0.45 6.6 0.34 1.67e-10 Lobe attachment (rater-scored or self-reported); CRC cis rs1005277 0.577 rs4934906 chr10:38015028 C/T cg25427524 chr10:38739819 LOC399744 -0.7 -12.04 -0.55 6.4e-28 Extrinsic epigenetic age acceleration; CRC cis rs826838 1.000 rs10880963 chr12:38748408 T/C cg13010199 chr12:38710504 ALG10B 0.47 6.08 0.32 3.34e-9 Heart rate; CRC cis rs4242434 0.927 rs2291231 chr8:22463912 C/T cg03733263 chr8:22462867 KIAA1967 1.03 19.54 0.73 5.76e-57 Exploratory eye movement dysfunction in schizophrenia (cognitive search score); CRC cis rs10992471 0.651 rs7043984 chr9:95529408 C/T cg14631576 chr9:95140430 CENPP -0.4 -7.17 -0.37 5.13e-12 Visceral adipose tissue/subcutaneous adipose tissue ratio; CRC cis rs4713118 0.869 rs9283880 chr6:27715243 A/C cg12172441 chr6:28176163 NA 0.53 7.33 0.37 1.85e-12 Parkinson's disease; CRC cis rs7647973 0.731 rs7617480 chr3:49210732 G/T cg20833759 chr3:49053208 WDR6;DALRD3 -0.43 -6.27 -0.33 1.16e-9 Menarche (age at onset); CRC cis rs17767392 0.958 rs7148679 chr14:72160321 T/C cg13720639 chr14:72061746 SIPA1L1 0.57 7.07 0.36 9.31e-12 Mitral valve prolapse; CRC cis rs10876993 0.890 rs1082502 chr12:58035706 C/T cg18357645 chr12:58087776 OS9 0.52 7.07 0.36 9.21e-12 Celiac disease or Rheumatoid arthritis; CRC cis rs4822044 0.617 rs13054514 chr22:42130383 A/G cg03806693 chr22:41940476 POLR3H 0.67 9.34 0.46 1.55e-18 Cannabis dependence symptom count; CRC trans rs7267979 0.932 rs446649 chr20:25467359 A/G cg17903999 chr18:56338584 MALT1 -0.43 -7.47 -0.38 7.29e-13 Liver enzyme levels (alkaline phosphatase); CRC cis rs1256061 0.603 rs960069 chr14:64745002 C/T cg23250157 chr14:64679961 SYNE2 0.38 6.0 0.31 5.27e-9 Hemoglobin concentration;Red blood cell count;Hematocrit; CRC cis rs8180040 0.903 rs11710013 chr3:47296921 T/C cg10298567 chr3:47292165 KIF9 -0.4 -6.63 -0.34 1.41e-10 Colorectal cancer; CRC cis rs11190604 1.000 rs4919470 chr10:102298920 C/T cg16342193 chr10:102329863 NA -0.38 -5.83 -0.31 1.33e-8 Palmitoleic acid (16:1n-7) levels; CRC cis rs59104589 0.521 rs62190414 chr2:242424687 A/G cg19488206 chr2:242435732 STK25 0.46 7.21 0.37 3.79e-12 Fibrinogen levels; CRC trans rs2303319 0.504 rs56009150 chr2:162598582 T/C cg14225146 chr17:72744664 SLC9A3R1 -0.68 -6.08 -0.32 3.32e-9 Cognitive function; CRC cis rs875971 0.545 rs11770063 chr7:65783016 G/A cg11764359 chr7:65958608 NA 0.45 5.73 0.3 2.21e-8 Aortic root size; CRC cis rs4555082 0.681 rs28588570 chr14:105709606 A/T cg13114125 chr14:105738426 BRF1 -0.76 -11.46 -0.53 7.99e-26 Mean platelet volume;Platelet distribution width; CRC cis rs4862750 0.872 rs6811837 chr4:187898162 G/A cg06074448 chr4:187884817 NA -0.59 -10.89 -0.51 8.55e-24 Lobe attachment (rater-scored or self-reported); CRC cis rs3733585 0.648 rs7378305 chr4:9954893 C/T cg00071950 chr4:10020882 SLC2A9 -0.55 -9.75 -0.47 6.96e-20 Cleft plate (environmental tobacco smoke interaction); CRC cis rs3796352 1.000 rs11710707 chr3:52975916 A/G cg07884673 chr3:53033167 SFMBT1 0.76 6.1 0.32 2.92e-9 Immune reponse to smallpox (secreted IL-2); CRC cis rs2239547 0.657 rs12488303 chr3:52862003 G/A cg15147215 chr3:52552868 STAB1 -0.43 -6.09 -0.32 3.12e-9 Schizophrenia; CRC cis rs6921919 0.583 rs16894021 chr6:28345026 C/A cg21251018 chr6:28226885 NKAPL 0.39 6.02 0.31 4.74e-9 Autism spectrum disorder or schizophrenia; CRC cis rs4664308 0.840 rs1870102 chr2:161070582 A/G cg03641300 chr2:160917029 PLA2R1 -0.71 -11.59 -0.54 2.83e-26 Idiopathic membranous nephropathy; CRC cis rs561341 0.663 rs72821936 chr17:30224068 C/G cg13647721 chr17:30228624 UTP6 0.62 8.01 0.4 2.05e-14 Hip circumference adjusted for BMI; CRC cis rs875971 0.862 rs801209 chr7:66019390 G/T cg00343986 chr7:65444356 GUSB -0.44 -6.15 -0.32 2.21e-9 Aortic root size; CRC cis rs9768139 1.000 rs9768139 chr7:158120731 G/A cg24154853 chr7:158122151 PTPRN2 -0.59 -9.85 -0.48 3.13e-20 Calcium levels; CRC trans rs6703335 0.870 rs10803142 chr1:243598234 A/G cg11502736 chr1:179923845 CEP350 0.46 6.54 0.34 2.42e-10 Schizophrenia;Schizophrenia, schizoaffective disorder or bipolar disorder; CRC cis rs4819052 0.851 rs2255774 chr21:46683851 A/T cg19498844 chr21:46707878 POFUT2;LOC642852 0.7 10.27 0.49 1.17e-21 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs4689388 0.926 rs4416547 chr4:6293967 G/A cg25554036 chr4:6271136 WFS1 0.54 8.73 0.43 1.29e-16 Type 2 diabetes and other traits;Type 2 diabetes; CRC cis rs4481887 0.927 rs4244185 chr1:248486913 A/G cg13385794 chr1:248469461 NA 0.4 7.1 0.36 7.96e-12 Common traits (Other); CRC cis rs853679 1.000 rs6905391 chr6:28262686 G/A cg03623178 chr6:28175578 NA 0.69 7.1 0.36 7.91e-12 Depression; CRC cis rs6933660 0.720 rs6936936 chr6:151753395 A/G cg14416726 chr6:151773293 C6orf211;RMND1 -0.62 -9.35 -0.46 1.34e-18 Menarche (age at onset); CRC cis rs4589502 0.800 rs4776855 chr15:67202075 T/C cg09911534 chr15:67153556 NA 0.43 5.84 0.31 1.26e-8 Lung cancer (smoking interaction); CRC cis rs634534 0.591 rs688862 chr11:65733393 A/G cg17985854 chr11:65770987 BANF1;EIF1AD 0.4 6.59 0.34 1.74e-10 Sum eosinophil basophil counts;Eosinophil counts; CRC cis rs4478137 0.931 rs3967762 chr4:164244976 T/C cg06758707 chr4:164254230 NPY1R 0.38 5.87 0.31 1.05e-8 Subjective well-being (multi-trait analysis);Subjective well-being; CRC cis rs7274811 0.625 rs293723 chr20:31927706 A/G cg03904042 chr20:32255491 NECAB3;C20orf134 -0.46 -6.49 -0.34 3.14e-10 Height; CRC cis rs10540 0.730 rs61876338 chr11:493730 A/G cg21784768 chr11:537496 LRRC56 -0.68 -6.51 -0.34 2.8e-10 Body mass index; CRC cis rs780096 0.546 rs4665976 chr2:27640325 A/G cg22903471 chr2:27725779 GCKR -0.36 -5.92 -0.31 7.96e-9 Total body bone mineral density; CRC cis rs709400 0.633 rs10143247 chr14:103920927 G/A cg12935359 chr14:103987150 CKB -0.48 -7.88 -0.4 4.89e-14 Body mass index; CRC cis rs6743376 0.642 rs4145014 chr2:113831185 A/G cg24553058 chr2:113831203 IL1F10 0.7 9.61 0.47 1.89e-19 Inflammatory biomarkers; CRC cis rs10207060 0.771 rs4852124 chr2:240680022 C/T cg07506560 chr2:240697449 NA 0.46 7.46 0.38 7.81e-13 Obesity-related traits; CRC cis rs11167764 1.000 rs6887599 chr5:141484349 G/A cg08523384 chr5:141488047 NDFIP1 -0.51 -8.48 -0.42 7.73e-16 Crohn's disease; CRC cis rs8014204 0.836 rs7150254 chr14:75299101 G/A cg03030879 chr14:75389066 RPS6KL1 -0.49 -7.98 -0.4 2.38e-14 Caffeine consumption; CRC cis rs868036 1.000 rs6494694 chr15:68057142 A/C cg05925327 chr15:68127851 NA 0.3 5.75 0.3 2.03e-8 Restless legs syndrome; CRC cis rs6604026 0.656 rs949915 chr1:93369774 A/G cg17283838 chr1:93427260 FAM69A -0.43 -5.79 -0.3 1.61e-8 Multiple sclerosis; CRC cis rs7739232 0.749 rs79359022 chr6:53527019 T/C cg15658676 chr6:53530538 KLHL31 -0.76 -5.9 -0.31 8.9e-9 Hip circumference adjusted for BMI; CRC cis rs2333194 0.846 rs7159794 chr14:73804443 G/A cg19682024 chr14:74008259 HEATR4;ACOT1 -0.41 -6.25 -0.33 1.29e-9 Bipolar disorder with mood-incongruent psychosis; CRC cis rs2739330 0.828 rs2877178 chr22:24251517 C/T cg04234412 chr22:24373322 LOC391322 -0.72 -11.43 -0.53 1.05e-25 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs1003719 0.788 rs2835577 chr21:38457457 T/C cg10648535 chr21:38446584 PIGP;TTC3 0.51 7.26 0.37 2.74e-12 Eye color traits; CRC cis rs5769765 0.955 rs9616204 chr22:50303530 T/C cg22709217 chr22:50311962 ALG12;CRELD2 -1.01 -16.54 -0.67 3.83e-45 Schizophrenia; CRC cis rs4423214 0.840 rs1792226 chr11:71176574 C/T cg13043300 chr11:71146211 DHCR7 -0.44 -5.91 -0.31 8.58e-9 Vitamin D levels; CRC cis rs1816752 1.000 rs7999554 chr13:25009769 C/A cg02811702 chr13:24901961 NA 0.47 6.49 0.34 3.22e-10 Obesity-related traits; CRC cis rs875971 0.964 rs1643388 chr7:65844562 T/C cg12463550 chr7:65579703 CRCP 0.48 6.96 0.36 1.89e-11 Aortic root size; CRC trans rs12599106 0.709 rs1501462 chr16:34964515 A/T cg01516881 chr6:292596 DUSP22 -0.65 -9.5 -0.46 4.38e-19 Menopause (age at onset); CRC cis rs6502050 0.835 rs8074267 chr17:80158325 A/G cg22110888 chr17:80059540 CCDC57 0.38 6.07 0.32 3.61e-9 Life satisfaction; CRC cis rs7618915 0.547 rs11130315 chr3:52697163 A/G cg10802521 chr3:52805072 NEK4 -0.59 -9.02 -0.45 1.55e-17 Bipolar disorder; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg16202187 chr19:17186497 HAUS8;MYO9B 0.48 6.65 0.34 1.19e-10 Anxiety disorder; CRC cis rs7605827 0.930 rs12692267 chr2:15572834 A/G cg19274914 chr2:15703543 NA -0.38 -5.8 -0.3 1.54e-8 Educational attainment (years of education); CRC cis rs1843834 0.505 rs4674911 chr2:225345254 A/G cg22455342 chr2:225449267 CUL3 0.65 8.55 0.43 4.66e-16 IgE levels in asthmatics (D.p. specific); CRC cis rs2066819 1.000 rs116849218 chr12:56683975 C/T cg26714650 chr12:56694279 CS -1.41 -11.64 -0.54 1.88e-26 Psoriasis vulgaris; CRC cis rs875971 0.792 rs6971752 chr7:65737986 G/A cg18252515 chr7:66147081 NA 0.4 5.77 0.3 1.82e-8 Aortic root size; CRC trans rs8002861 0.664 rs9525873 chr13:44482204 T/C cg17145862 chr1:211918768 LPGAT1 0.61 10.43 0.5 3.31e-22 Leprosy; CRC cis rs17095355 1.000 rs17126883 chr10:111694696 A/G cg00817464 chr10:111662876 XPNPEP1 -0.58 -6.9 -0.36 2.69e-11 Biliary atresia; CRC trans rs11098499 0.954 rs6849171 chr4:120409549 G/A cg25214090 chr10:38739885 LOC399744 0.65 10.49 0.5 2.16e-22 Corneal astigmatism; CRC cis rs12134245 0.527 rs6681073 chr1:92022597 A/C cg25838465 chr1:92012736 NA -0.44 -6.51 -0.34 2.83e-10 Breast cancer; CRC cis rs7089973 0.966 rs61867966 chr10:116584362 T/C cg23260525 chr10:116636907 FAM160B1 0.33 6.52 0.34 2.58e-10 Bipolar disorder or attention deficit hyperactivity disorder; CRC cis rs7937682 0.889 rs541198 chr11:111475340 A/G cg09085632 chr11:111637200 PPP2R1B -0.98 -19.21 -0.73 1.09e-55 Primary sclerosing cholangitis; CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg11668638 chr6:42952412 PPP2R5D -0.54 -6.58 -0.34 1.81e-10 Diisocyanate-induced asthma; CRC cis rs3126085 1.000 rs4845756 chr1:152254919 T/A cg09127314 chr1:152161683 NA 0.45 5.86 0.31 1.14e-8 Atopic dermatitis; CRC trans rs2243480 1.000 rs313813 chr7:65503500 C/T cg10756647 chr7:56101905 PSPH 0.76 7.81 0.4 7.54e-14 Diabetic kidney disease; CRC cis rs2204008 0.748 rs11514352 chr12:38246954 C/T cg13010199 chr12:38710504 ALG10B 0.45 5.75 0.3 2.06e-8 Bladder cancer; CRC cis rs7113874 0.589 rs7101471 chr11:8463622 A/G cg02811074 chr11:8615871 STK33 0.33 5.75 0.3 2.09e-8 Body mass index in physically active individuals;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs16973500 0.711 rs72801789 chr16:71959748 C/T cg00732059 chr16:71740210 PHLPP2 -0.66 -6.76 -0.35 6.35e-11 Response to anti-TNF therapy in rheumatoid arthritis;Attention deficit hyperactivity disorder and conduct disorder; CRC cis rs7208859 0.623 rs11657662 chr17:29076347 A/G cg01831904 chr17:28903510 LRRC37B2 0.65 6.7 0.35 9.21e-11 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs875971 0.545 rs67688847 chr7:65626051 G/A cg02869306 chr7:64672164 INTS4L1 -0.43 -6.18 -0.32 1.86e-9 Aortic root size; CRC cis rs10170846 0.731 rs10180632 chr2:223526384 G/A cg25565276 chr2:223520875 FARSB 0.47 6.31 0.33 8.84e-10 Schizophrenia (inflammation and infection response interaction); CRC cis rs8180040 0.620 rs17784127 chr3:47061700 T/C cg10298567 chr3:47292165 KIF9 0.38 5.86 0.31 1.15e-8 Colorectal cancer; CRC cis rs477692 0.637 rs7098627 chr10:131315866 C/T cg05714579 chr10:131428358 MGMT 0.5 6.99 0.36 1.5e-11 Response to temozolomide; CRC cis rs3096299 0.719 rs2911262 chr16:89515041 C/T cg00750074 chr16:89608354 SPG7 -0.51 -7.76 -0.39 1.09e-13 Multiple myeloma (IgH translocation); CRC cis rs6860806 0.661 rs4705929 chr5:131584178 G/T cg22638593 chr5:131593259 PDLIM4 0.4 7.33 0.37 1.75e-12 Breast cancer; CRC cis rs17376456 0.825 rs34592268 chr5:93232751 G/C cg21475434 chr5:93447410 FAM172A 0.8 8.11 0.41 9.83e-15 Diabetic retinopathy; CRC cis rs2404602 0.647 rs4312276 chr15:77164361 T/C cg23625390 chr15:77176239 SCAPER -0.85 -12.71 -0.57 2.25e-30 Blood metabolite levels; CRC cis rs7618915 0.547 rs7642198 chr3:52677960 T/C cg08222913 chr3:52553049 STAB1 -0.34 -6.14 -0.32 2.4e-9 Bipolar disorder; CRC cis rs4862750 0.914 rs10027250 chr4:187873460 T/C cg03647317 chr4:187891568 NA -0.55 -10.24 -0.49 1.53e-21 Lobe attachment (rater-scored or self-reported); CRC cis rs2739330 0.760 rs5760095 chr22:24247293 A/G cg04234412 chr22:24373322 LOC391322 -0.83 -13.92 -0.61 5.83e-35 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs12295403 1.000 rs12295403 chr11:18689653 G/T cg07538406 chr11:18686895 NA -0.4 -6.09 -0.32 3.2e-9 Ovarian reserve; CRC cis rs13108904 0.846 rs3775100 chr4:1225106 T/C cg21620606 chr4:1342894 KIAA1530 0.38 6.82 0.35 4.26e-11 Obesity-related traits; CRC cis rs5769765 0.908 rs9616213 chr22:50317851 T/G cg22709217 chr22:50311962 ALG12;CRELD2 -1.06 -15.43 -0.65 8.48e-41 Schizophrenia; CRC cis rs9303401 0.614 rs3803752 chr17:56540267 C/T cg10487724 chr17:56770010 TEX14;RAD51C 0.76 8.79 0.44 8.52e-17 Cognitive test performance; CRC cis rs7703744 0.681 rs11957102 chr5:118701899 G/T cg23985447 chr5:118691066 TNFAIP8 0.4 5.64 0.3 3.66e-8 Lobe attachment (rater-scored or self-reported); CRC trans rs2303319 0.504 rs62187612 chr2:162432494 A/G cg12500891 chr11:57225987 NA -0.69 -6.06 -0.32 3.82e-9 Cognitive function; CRC cis rs796364 0.806 rs6435040 chr2:200861161 T/G cg25936922 chr2:200820526 C2orf60;C2orf47 0.68 6.63 0.34 1.34e-10 Schizophrenia; CRC cis rs13108904 0.967 rs4405964 chr4:1278814 A/G cg19318889 chr4:1322082 MAEA 0.4 5.74 0.3 2.13e-8 Obesity-related traits; CRC cis rs7923452 0.507 rs612802 chr10:30756441 G/A cg18806716 chr10:30721971 MAP3K8 -0.58 -8.2 -0.41 5.61e-15 Itch intensity from mosquito bite; CRC cis rs9611565 0.592 rs1811113 chr22:42073134 C/T cg06634786 chr22:41940651 POLR3H 0.61 6.86 0.35 3.38e-11 Vitiligo; CRC cis rs11122272 0.735 rs2749706 chr1:231527170 C/A cg06096015 chr1:231504339 EGLN1 0.4 6.04 0.32 4.26e-9 Hemoglobin concentration; CRC cis rs262150 0.851 rs2730249 chr7:158767628 A/G cg12590608 chr7:158785262 NA -0.48 -9.05 -0.45 1.25e-17 Facial morphology (factor 20); CRC cis rs2153535 0.580 rs1932275 chr6:8442333 T/A cg07606381 chr6:8435919 SLC35B3 0.68 10.86 0.51 1.08e-23 Motion sickness; CRC cis rs62229266 0.771 rs7280136 chr21:37432910 C/G cg12218747 chr21:37451666 NA 0.37 6.45 0.34 4.01e-10 Mitral valve prolapse; CRC cis rs9372498 0.536 rs62421536 chr6:118727972 G/A cg15382696 chr6:118971807 C6orf204 0.56 6.77 0.35 5.81e-11 Diastolic blood pressure; CRC cis rs1728785 0.892 rs1103955 chr16:68588488 T/G cg02972257 chr16:68554789 NA -0.61 -7.61 -0.39 2.89e-13 Ulcerative colitis; CRC cis rs4731207 0.596 rs1481328 chr7:124631026 C/T cg23710748 chr7:124431027 NA 0.4 6.38 0.33 5.97e-10 Cutaneous malignant melanoma; CRC cis rs561341 0.714 rs474455 chr17:30312465 A/T cg12193833 chr17:30244370 NA -0.62 -8.05 -0.41 1.51e-14 Hip circumference adjusted for BMI; CRC cis rs274567 0.501 rs272856 chr5:131687081 G/C cg22638593 chr5:131593259 PDLIM4 0.4 6.4 0.33 5.33e-10 Blood metabolite levels; CRC cis rs1153858 1.000 rs59889118 chr15:45618730 G/A cg10760299 chr15:45669010 GATM 0.53 8.27 0.41 3.35e-15 Homoarginine levels; CRC cis rs2180341 0.782 rs6924274 chr6:127721556 T/A cg24812749 chr6:127587940 RNF146 0.68 9.26 0.45 2.69e-18 Breast cancer; CRC cis rs17767392 0.958 rs35760654 chr14:71983757 C/T cg13720639 chr14:72061746 SIPA1L1 -0.57 -7.26 -0.37 2.77e-12 Mitral valve prolapse; CRC cis rs9486719 1.000 rs12213426 chr6:96896035 T/C cg06623918 chr6:96969491 KIAA0776 -0.81 -9.51 -0.46 4.17e-19 Migraine;Coronary artery disease; CRC cis rs8078723 0.714 rs9915252 chr17:38145088 C/G cg17467752 chr17:38218738 THRA -0.57 -9.05 -0.45 1.27e-17 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); CRC cis rs62244186 0.748 rs6441861 chr3:44652287 A/G cg10263370 chr3:44754102 ZNF502 -0.38 -6.25 -0.33 1.24e-9 Depressive symptoms; CRC cis rs4332037 0.539 rs11763750 chr7:2080114 G/A cg21155852 chr7:2048760 MAD1L1 -0.5 -6.79 -0.35 5.19e-11 Bipolar disorder; CRC trans rs7647973 0.710 rs6446284 chr3:49616997 A/G cg21659725 chr3:3221576 CRBN -0.69 -7.14 -0.37 6.11e-12 Menarche (age at onset); CRC cis rs4654899 0.772 rs12404954 chr1:21074727 A/G cg02927042 chr1:21476669 EIF4G3 -0.46 -7.0 -0.36 1.45e-11 Superior frontal gyrus grey matter volume; CRC cis rs7224314 1.000 rs7221926 chr17:65352181 A/T cg01507342 chr17:65387096 PITPNC1 -0.41 -5.62 -0.3 4.02e-8 Diisocyanate-induced asthma; CRC cis rs9322193 0.962 rs3805753 chr6:150116798 C/T cg07701084 chr6:150067640 NUP43 0.47 6.61 0.34 1.51e-10 Lung cancer; CRC cis rs9372498 0.505 rs9320655 chr6:118830981 T/C cg22561889 chr6:118971681 C6orf204 0.52 6.69 0.35 9.59e-11 Diastolic blood pressure; CRC cis rs13118159 0.899 rs3796613 chr4:1353321 A/T cg23123621 chr4:1343375 KIAA1530 0.35 6.14 0.32 2.4e-9 Longevity; CRC cis rs3764400 0.508 rs74412170 chr17:46117509 C/G cg10706073 chr17:46328419 SKAP1 -0.67 -7.21 -0.37 3.76e-12 Body mass index; CRC cis rs34779708 0.931 rs11596502 chr10:35387187 A/C cg03585969 chr10:35415529 CREM 0.66 8.66 0.43 2.23e-16 Inflammatory bowel disease;Crohn's disease; CRC cis rs13191362 1.000 rs13220181 chr6:163004401 T/A cg23758597 chr6:163146217 PARK2 -0.51 -5.91 -0.31 8.33e-9 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs939574 1.000 rs45488900 chr2:220116509 G/T cg00496455 chr2:220118770 TUBA4A;TUBA4B 0.89 8.96 0.44 2.54e-17 Platelet distribution width; CRC cis rs2760061 0.846 rs3094912 chr1:228209815 T/A cg18477163 chr1:228402036 OBSCN 0.41 6.81 0.35 4.56e-11 Diastolic blood pressure; CRC cis rs3087591 0.853 rs2953003 chr17:29502731 T/C cg24425628 chr17:29625626 OMG;NF1 0.86 16.15 0.66 1.31e-43 Hip circumference; CRC cis rs9467711 0.606 rs9358930 chr6:26357011 C/T cg16898833 chr6:26189333 HIST1H4D 0.75 6.55 0.34 2.26e-10 Autism spectrum disorder or schizophrenia; CRC cis rs1865760 0.613 rs7749342 chr6:25920265 T/C cg17691542 chr6:26056736 HIST1H1C 0.45 6.93 0.36 2.21e-11 Height; CRC cis rs10504229 0.683 rs73603874 chr8:58108340 G/A cg24829409 chr8:58192753 C8orf71 -0.56 -7.95 -0.4 3.02e-14 Developmental language disorder (linguistic errors); CRC cis rs853679 0.517 rs9295759 chr6:28124469 C/T cg12172441 chr6:28176163 NA 0.64 7.53 0.38 5.03e-13 Depression; CRC cis rs9300255 0.602 rs1617434 chr12:123649486 A/G cg00376283 chr12:123451042 ABCB9 0.56 6.94 0.36 2.03e-11 Neutrophil percentage of white cells; CRC cis rs208515 0.518 rs12209790 chr6:66662965 T/C cg07460842 chr6:66804631 NA 0.94 11.82 0.55 4.02e-27 Exhaled nitric oxide levels; CRC cis rs853679 0.517 rs9393897 chr6:28127710 G/T cg12172441 chr6:28176163 NA 0.64 7.53 0.38 5.03e-13 Depression; CRC cis rs2404602 0.692 rs67010831 chr15:76965308 T/G cg03037974 chr15:76606532 NA 0.7 12.45 0.57 2.07e-29 Blood metabolite levels; CRC cis rs1552244 1.000 rs67569278 chr3:10149893 T/C cg16606324 chr3:10149918 C3orf24 0.74 9.83 0.48 3.64e-20 Alzheimer's disease; CRC cis rs6570726 0.764 rs448258 chr6:145869145 C/A cg13319975 chr6:146136371 FBXO30 -0.46 -6.85 -0.35 3.67e-11 Lobe attachment (rater-scored or self-reported); CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg22658884 chr19:14192470 NA 0.49 6.3 0.33 9.48e-10 Thyroid stimulating hormone; CRC cis rs3858526 0.523 rs10769289 chr11:5886607 C/T cg13902645 chr11:5959945 NA -0.68 -10.03 -0.48 7.91e-21 DNA methylation (variation); CRC cis rs10504229 0.683 rs7820559 chr8:58142662 C/T cg05313129 chr8:58192883 C8orf71 -0.44 -6.15 -0.32 2.27e-9 Developmental language disorder (linguistic errors); CRC cis rs7412746 0.658 rs2230061 chr1:150727539 G/A cg17724175 chr1:150552817 MCL1 0.49 7.26 0.37 2.88e-12 Melanoma; CRC cis rs2290159 0.752 rs5746182 chr3:12672550 A/G cg23032965 chr3:12705835 RAF1 0.5 6.38 0.33 5.92e-10 Cholesterol, total; CRC cis rs3858526 0.834 rs10839169 chr11:6003190 C/G cg02574844 chr11:5959923 NA -0.43 -5.65 -0.3 3.48e-8 DNA methylation (variation); CRC cis rs9560113 1.000 rs9555812 chr13:112181535 A/G cg10483660 chr13:112241077 NA 0.36 5.81 0.31 1.46e-8 Menarche (age at onset); CRC cis rs17539620 0.628 rs62432728 chr6:154829511 G/C cg20019720 chr6:154832845 CNKSR3 0.5 8.26 0.41 3.58e-15 Lipoprotein (a) levels; CRC cis rs67311347 0.911 rs6773917 chr3:40469254 G/T cg09455208 chr3:40491958 NA 0.42 8.56 0.43 4.32e-16 Renal cell carcinoma; CRC cis rs8141529 0.509 rs7287124 chr22:29239157 A/G cg02153584 chr22:29168773 CCDC117 0.47 6.55 0.34 2.26e-10 Lymphocyte counts; CRC cis rs12142240 0.698 rs77185326 chr1:46818417 T/C cg14993813 chr1:46806288 NSUN4 -0.48 -6.15 -0.32 2.24e-9 Menopause (age at onset); CRC cis rs6951245 1.000 rs11766526 chr7:1101433 G/A cg24642844 chr7:1081250 C7orf50 -0.76 -9.16 -0.45 5.78e-18 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs929354 0.772 rs2301916 chr7:156974127 G/T cg17757837 chr7:157058334 UBE3C 0.74 12.59 0.57 5.99e-30 Body mass index; CRC cis rs4713118 0.513 rs156738 chr6:28014025 G/C cg25164649 chr6:28176230 NA 0.59 8.37 0.42 1.63e-15 Parkinson's disease; CRC cis rs4409675 0.576 rs10751725 chr1:28216191 A/C cg11176159 chr1:28213800 NA -0.32 -6.33 -0.33 7.82e-10 Corneal astigmatism; CRC cis rs13108904 0.901 rs6826029 chr4:1307689 A/G cg24560729 chr4:1342394 KIAA1530 0.34 6.26 0.33 1.24e-9 Obesity-related traits; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg15637605 chr3:148847786 HPS3 0.47 6.21 0.32 1.59e-9 Thyroid stimulating hormone; CRC trans rs4263408 0.934 rs9683743 chr4:39703194 A/C cg27629583 chr1:151431750 POGZ -0.41 -5.96 -0.31 6.54e-9 Plasma amyloid beta peptide concentrations (ABx-40); CRC cis rs35146811 0.586 rs10267212 chr7:99595422 T/C cg03265037 chr7:99691720 MIR25;MCM7;MIR106B;MIR93 0.44 5.92 0.31 8.17e-9 Coronary artery disease; CRC cis rs6942756 1.000 rs9640854 chr7:128884057 A/T cg02491457 chr7:128862824 NA -0.75 -10.15 -0.49 2.97e-21 White matter hyperintensity burden; CRC cis rs2204008 0.604 rs11172718 chr12:38069819 T/C cg26384229 chr12:38710491 ALG10B 0.67 9.3 0.46 2.04e-18 Bladder cancer; CRC trans rs478304 0.593 rs7120713 chr11:65483374 G/C cg17712092 chr4:129076599 LARP1B -0.44 -6.27 -0.33 1.12e-9 Acne (severe); CRC cis rs875971 1.000 rs2420591 chr7:65912381 T/C cg18876405 chr7:65276391 NA 0.52 8.85 0.44 5.32e-17 Aortic root size; CRC cis rs73001065 0.636 rs56241616 chr19:19506092 C/T cg03709012 chr19:19516395 GATAD2A 0.83 6.98 0.36 1.64e-11 LDL cholesterol; CRC cis rs7236492 0.748 rs11663658 chr18:77197555 T/C cg15644404 chr18:77186268 NFATC1 -0.57 -5.79 -0.3 1.64e-8 Inflammatory bowel disease;Crohn's disease; CRC cis rs8177253 1.000 rs8177248 chr3:133479626 C/T cg11941060 chr3:133502564 NA -0.57 -9.73 -0.47 7.6e-20 Iron status biomarkers; CRC cis rs3741404 0.791 rs7102177 chr11:63909228 T/C cg18225595 chr11:63971243 STIP1 0.65 10.61 0.5 8.49e-23 Platelet count; CRC cis rs9910055 0.530 rs2269905 chr17:42294462 A/G cg19774624 chr17:42201019 HDAC5 -0.39 -5.85 -0.31 1.18e-8 Total body bone mineral density; CRC cis rs2230307 0.536 rs834164 chr1:100603948 A/C cg24955406 chr1:100503596 HIAT1 -0.47 -5.65 -0.3 3.52e-8 Carotid intima media thickness; CRC cis rs9359856 0.564 rs34732313 chr6:90368380 G/A cg13799429 chr6:90582589 CASP8AP2 -0.73 -8.01 -0.4 2.01e-14 Bipolar disorder; CRC trans rs3858526 0.883 rs7481923 chr11:5933342 T/C cg01505111 chr6:125621795 HDDC2 0.38 6.0 0.31 5.25e-9 DNA methylation (variation); CRC cis rs11212617 0.934 rs11212551 chr11:108078693 G/T cg12106634 chr11:108092400 ATM;NPAT 0.42 6.28 0.33 1.08e-9 Response to metformin in type 2 diabetes (glycemic); CRC cis rs1218582 0.710 rs9794000 chr1:154878876 T/A cg24250549 chr1:154909240 PMVK 0.67 11.55 0.54 3.98e-26 Prostate cancer; CRC cis rs853679 0.569 rs9348798 chr6:28143011 G/A cg25164649 chr6:28176230 NA 0.78 9.69 0.47 1.04e-19 Depression; CRC cis rs8180040 0.934 rs12630641 chr3:47534836 G/T cg02527881 chr3:46936655 PTH1R -0.41 -7.83 -0.4 6.87e-14 Colorectal cancer; CRC cis rs7605827 0.930 rs6737962 chr2:15526998 T/G cg19274914 chr2:15703543 NA 0.38 5.63 0.3 3.81e-8 Educational attainment (years of education); CRC trans rs10983614 1.000 rs7867776 chr9:120072627 A/G cg11733294 chr11:118123053 MPZL3 0.44 6.0 0.31 5.11e-9 Survival in pancreatic cancer; CRC cis rs875971 0.571 rs160647 chr7:65554352 C/T cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.61 -7.7 -0.39 1.65e-13 Aortic root size; CRC cis rs7552404 0.920 rs1612097 chr1:76218875 C/T cg03433033 chr1:76189801 ACADM 0.74 11.17 0.52 8.95e-25 Blood metabolite levels;Acylcarnitine levels; CRC cis rs6502050 0.871 rs6502055 chr17:80070868 G/T cg25804541 chr17:80189381 SLC16A3 0.31 5.68 0.3 3e-8 Life satisfaction; CRC cis rs7703744 0.634 rs3797340 chr5:118691737 C/G cg02283238 chr5:118691126 TNFAIP8 0.47 6.47 0.34 3.5e-10 Lobe attachment (rater-scored or self-reported); CRC cis rs4363385 0.747 rs4323653 chr1:152983359 T/G cg25856811 chr1:152973957 SPRR3 -0.25 -6.77 -0.35 5.83e-11 Inflammatory skin disease; CRC trans rs7618501 1.000 rs7618501 chr3:49772647 A/G cg21665057 chr3:196295764 WDR53;FBXO45 -0.86 -15.78 -0.66 3.77e-42 Intelligence (multi-trait analysis); CRC cis rs6840360 0.967 rs6832562 chr4:152602798 A/G cg09659197 chr4:152720779 NA 0.52 11.13 0.52 1.23e-24 Intelligence (multi-trait analysis); CRC cis rs1033849 0.507 rs9507260 chr13:24723932 A/G cg14860438 chr13:24731302 NA 0.36 5.94 0.31 7.16e-9 Cerebrospinal fluid biomarker levels; CRC cis rs9649213 0.574 rs3801251 chr7:98027618 T/C cg21770322 chr7:97807741 LMTK2 0.52 8.49 0.42 7.38e-16 Prostate cancer (SNP x SNP interaction); CRC cis rs9614461 0.609 rs9614653 chr22:45767391 A/G cg23503501 chr22:45809793 SMC1B;RIBC2 -0.64 -6.98 -0.36 1.6e-11 Tonsillectomy; CRC cis rs9291683 0.595 rs11731110 chr4:10037346 T/C cg00071950 chr4:10020882 SLC2A9 0.67 12.66 0.57 3.54e-30 Bone mineral density; CRC cis rs13108904 0.935 rs1620928 chr4:1279124 C/T cg21620606 chr4:1342894 KIAA1530 -0.4 -7.08 -0.36 8.97e-12 Obesity-related traits; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg13123156 chr7:105162878 PUS7 0.44 6.49 0.34 3.08e-10 Response to antipsychotic treatment; CRC cis rs28386778 0.897 rs2665823 chr17:61885917 G/A cg06601766 chr17:61851465 DDX42;CCDC47 0.44 5.94 0.31 7.25e-9 Prudent dietary pattern; CRC cis rs11098499 0.615 rs28551750 chr4:120264901 C/T cg24375607 chr4:120327624 NA 0.48 7.66 0.39 2.1e-13 Corneal astigmatism; CRC cis rs9487051 0.872 rs9487038 chr6:109610152 T/C cg21918786 chr6:109611834 NA -0.44 -8.13 -0.41 8.67e-15 Reticulocyte fraction of red cells; CRC cis rs35110281 0.626 rs162367 chr21:44934857 A/G cg01579765 chr21:45077557 HSF2BP -0.36 -6.72 -0.35 8.23e-11 Mean corpuscular volume; CRC cis rs743757 0.878 rs9867588 chr3:50526880 T/C cg09545109 chr3:50388910 TUSC4;CYB561D2 0.44 5.96 0.31 6.47e-9 Diastolic blood pressure; CRC cis rs13118159 0.573 rs7664763 chr4:1352305 A/G cg20887711 chr4:1340912 KIAA1530 0.75 10.9 0.52 7.74e-24 Longevity; CRC cis rs6557786 0.636 rs17052934 chr8:24840319 A/C cg22562942 chr8:24772309 NEFM -0.29 -6.0 -0.31 5.17e-9 Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 2 peripheral neuropathy); CRC cis rs7916697 0.898 rs1900005 chr10:69998055 A/C cg06988349 chr10:69991859 ATOH7 -0.34 -6.29 -0.33 1.03e-9 Optic disc area; CRC cis rs4713118 0.869 rs6930992 chr6:27712120 A/C cg12172441 chr6:28176163 NA 0.52 7.19 0.37 4.51e-12 Parkinson's disease; CRC cis rs9837602 1.000 rs62285461 chr3:99767642 C/T cg07805332 chr3:99536008 MIR548G;C3orf26 -0.48 -6.33 -0.33 8.13e-10 Breast cancer; CRC trans rs2832077 0.943 rs2832099 chr21:30173460 A/G cg14791747 chr16:20752902 THUMPD1 0.54 7.12 0.37 6.87e-12 Cognitive test performance; CRC cis rs8060686 0.858 rs13334918 chr16:67901343 A/G cg01951491 chr16:67709440 GFOD2 -0.44 -5.85 -0.31 1.17e-8 HDL cholesterol;Metabolic syndrome; CRC cis rs8141529 0.509 rs5762863 chr22:29253335 A/C cg02153584 chr22:29168773 CCDC117 0.52 7.45 0.38 8.13e-13 Lymphocyte counts; CRC cis rs1949733 0.877 rs940133 chr4:8473614 T/C cg13073564 chr4:8508604 NA -0.5 -7.33 -0.37 1.74e-12 Response to antineoplastic agents; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg11087358 chr12:57940980 DCTN2 0.51 6.75 0.35 6.78e-11 Thyroid stimulating hormone; CRC cis rs7258465 1.000 rs2278238 chr19:18576484 T/C cg10790698 chr19:18539756 SSBP4 -0.45 -8.61 -0.43 3.07e-16 Breast cancer; CRC trans rs6544773 0.668 rs341599 chr2:45066716 T/C cg10208897 chr5:178548229 ADAMTS2 0.35 6.06 0.32 3.71e-9 Mosquito bite size; CRC cis rs2952156 0.876 rs2313171 chr17:37833842 T/C cg20243544 chr17:37824526 PNMT 0.55 8.95 0.44 2.66e-17 Asthma; CRC trans rs11039798 0.588 rs1847640 chr11:49004025 C/T cg15704280 chr7:45808275 SEPT13 0.65 6.64 0.34 1.27e-10 Axial length; CRC cis rs10504229 1.000 rs1961778 chr8:58168756 G/A cg21724239 chr8:58056113 NA 0.39 5.83 0.31 1.29e-8 Developmental language disorder (linguistic errors); CRC cis rs6831352 0.877 rs2602890 chr4:100043179 C/T cg12011299 chr4:100065546 ADH4 0.5 9.46 0.46 6e-19 Alcohol dependence; CRC cis rs769267 0.895 rs2315279 chr19:19479936 C/A cg01262667 chr19:19385393 TM6SF2 -0.38 -6.4 -0.33 5.41e-10 Tonsillectomy; CRC cis rs6835098 0.692 rs7657374 chr4:174065756 A/T cg08422745 chr4:174089978 GALNT7 -0.72 -10.66 -0.51 5.48e-23 Dementia and core Alzheimer's disease neuropathologic changes; CRC cis rs4824093 0.610 rs73441745 chr22:50237606 G/A cg22709217 chr22:50311962 ALG12;CRELD2 -1.0 -8.09 -0.41 1.13e-14 Amyotrophic lateral sclerosis (sporadic); CRC cis rs6502050 0.699 rs9901808 chr17:80107814 C/T cg22110888 chr17:80059540 CCDC57 0.4 6.31 0.33 9.13e-10 Life satisfaction; CRC cis rs4478858 0.698 rs10914370 chr1:31854955 T/C cg00250761 chr1:31883323 NA -0.43 -8.28 -0.42 3.22e-15 Alcohol dependence; CRC cis rs8060686 0.641 rs8064114 chr16:68240185 G/A cg26727032 chr16:67993705 SLC12A4 -0.59 -7.81 -0.4 7.61e-14 HDL cholesterol;Metabolic syndrome; CRC cis rs561341 1.000 rs55962687 chr17:30260369 C/T cg00745463 chr17:30367425 LRRC37B -0.92 -10.16 -0.49 2.86e-21 Hip circumference adjusted for BMI; CRC cis rs10256972 0.758 rs2280724 chr7:1064720 A/G cg03188948 chr7:1209495 NA 0.44 6.29 0.33 1.04e-9 Longevity;Endometriosis; CRC cis rs10924970 0.967 rs11585350 chr1:235482739 A/G cg26050004 chr1:235667680 B3GALNT2 0.41 6.14 0.32 2.41e-9 Asthma; CRC cis rs17401966 0.931 rs4240911 chr1:10307453 A/G cg19773385 chr1:10388646 KIF1B -0.64 -9.95 -0.48 1.5e-20 Hepatocellular carcinoma; CRC cis rs4713118 0.513 rs149954 chr6:28035246 G/A cg20615401 chr6:28092323 ZSCAN16 0.47 6.26 0.33 1.22e-9 Parkinson's disease; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg22897130 chr10:89419623 PAPSS2 0.39 6.38 0.33 5.98e-10 Liver disease severity in Alagille syndrome; CRC cis rs12474201 0.569 rs13411633 chr2:46932666 A/G cg06386533 chr2:46925753 SOCS5 0.59 8.89 0.44 4.07e-17 Height; CRC cis rs7589728 0.925 rs78829281 chr2:88502293 T/A cg24977027 chr2:88469347 THNSL2 0.52 5.94 0.31 7.21e-9 Plasma clusterin levels; CRC trans rs66573146 0.572 rs66611116 chr4:6953270 A/G cg07817883 chr1:32538562 TMEM39B 1.13 11.95 0.55 1.43e-27 Granulocyte percentage of myeloid white cells; CRC cis rs1218582 0.772 rs4845693 chr1:154911257 A/G cg06221963 chr1:154839813 KCNN3 0.77 15.06 0.64 2.42e-39 Prostate cancer; CRC cis rs6815814 0.851 rs11466617 chr4:38780471 T/C cg06935464 chr4:38784597 TLR10 0.59 5.94 0.31 7.25e-9 Breast cancer; CRC cis rs4973397 0.519 rs1669083 chr2:232196564 A/G cg13347044 chr2:232276743 NA -0.4 -6.18 -0.32 1.86e-9 Anti-saccade response; CRC cis rs6860806 0.661 rs334902 chr5:131586559 C/G cg18758796 chr5:131593413 PDLIM4 0.45 8.14 0.41 8.41e-15 Breast cancer; CRC cis rs3768617 0.510 rs12061219 chr1:183101471 G/A ch.1.3577855R chr1:183094577 LAMC1 0.89 15.86 0.66 1.84e-42 Fuchs's corneal dystrophy; CRC cis rs34375054 0.526 rs117431213 chr12:125675271 C/G cg25124228 chr12:125621409 AACS -0.57 -8.09 -0.41 1.14e-14 Post bronchodilator FEV1/FVC ratio; CRC cis rs875971 0.545 rs35459055 chr7:65944386 G/A cg03233332 chr7:66118400 NA -0.43 -6.0 -0.31 5.27e-9 Aortic root size; CRC cis rs6460942 1.000 rs7792759 chr7:12311715 A/G cg06484146 chr7:12443880 VWDE 0.75 7.28 0.37 2.48e-12 Coronary artery disease; CRC cis rs7666738 0.830 rs115712871 chr4:98954535 A/T cg05340658 chr4:99064831 C4orf37 0.61 9.54 0.47 3.45e-19 Colonoscopy-negative controls vs population controls; CRC cis rs11148252 0.595 rs4885117 chr13:53153027 T/C cg20354231 chr13:53171401 NA -0.44 -7.19 -0.37 4.48e-12 Lewy body disease; CRC cis rs2032447 0.736 rs115810 chr6:25975883 G/C cg04800585 chr6:26043546 HIST1H2BB 0.61 8.97 0.44 2.38e-17 Intelligence (multi-trait analysis); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg16385431 chr13:115079815 ZNF828 0.4 6.1 0.32 2.91e-9 Response to antipsychotic treatment; CRC cis rs6060717 0.610 rs6058393 chr20:34608664 A/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.4 -5.98 -0.31 5.81e-9 Hip circumference adjusted for BMI; CRC cis rs7959452 0.557 rs7980883 chr12:69778914 C/T cg20891283 chr12:69753455 YEATS4 0.91 17.31 0.69 3.38e-48 Blood protein levels; CRC trans rs8002861 0.754 rs7330760 chr13:44403088 A/T cg12856521 chr11:46389249 DGKZ -0.5 -8.2 -0.41 5.3e-15 Leprosy; CRC cis rs9929218 0.551 rs3785135 chr16:68728976 A/C cg01251360 chr16:68772225 CDH1 0.23 5.66 0.3 3.27e-8 Colorectal cancer; CRC cis rs2013441 1.000 rs2243732 chr17:20088589 C/G cg13482628 chr17:19912719 NA -0.4 -6.07 -0.32 3.43e-9 Obesity-related traits; CRC cis rs12477438 0.501 rs1133977 chr2:99741984 G/T cg26064155 chr2:99771622 LIPT1;TSGA10 -0.79 -13.66 -0.6 6e-34 Chronic sinus infection; CRC cis rs2617583 0.967 rs2652509 chr5:1448247 A/G cg07151155 chr5:1473589 LPCAT1 -0.39 -6.07 -0.32 3.58e-9 Breast cancer; CRC cis rs6665290 0.904 rs3768425 chr1:227178127 A/G cg10327440 chr1:227177885 CDC42BPA -1.04 -23.9 -0.8 7.05e-74 Myeloid white cell count; CRC cis rs2576037 0.583 rs9947131 chr18:44534769 G/T cg23996704 chr18:44553084 KATNAL2 -0.4 -8.01 -0.4 2e-14 Personality dimensions; CRC cis rs736408 0.540 rs4687637 chr3:52634092 C/T cg05573699 chr3:52720067 GNL3;PBRM1 -0.45 -6.47 -0.34 3.47e-10 Bipolar disorder; CRC trans rs7618501 0.699 rs2681781 chr3:49898273 A/G cg21659725 chr3:3221576 CRBN 0.68 10.66 0.51 5.61e-23 Intelligence (multi-trait analysis); CRC cis rs9733 0.596 rs72702570 chr1:150688196 C/T cg17724175 chr1:150552817 MCL1 0.57 9.12 0.45 7.76e-18 Tonsillectomy; CRC cis rs4654899 1.000 rs12133780 chr1:21270808 G/A cg02927042 chr1:21476669 EIF4G3 -0.48 -7.61 -0.39 2.87e-13 Superior frontal gyrus grey matter volume; CRC cis rs440932 0.565 rs19334 chr8:9009906 C/T cg06636001 chr8:8085503 FLJ10661 0.46 6.66 0.34 1.15e-10 High light scatter reticulocyte percentage of red cells; CRC cis rs10504229 0.593 rs17192845 chr8:58053339 C/T cg11062466 chr8:58055876 NA 0.59 7.22 0.37 3.7e-12 Developmental language disorder (linguistic errors); CRC cis rs6685188 0.920 rs6593964 chr1:205662337 G/T cg11965913 chr1:205819406 PM20D1 0.44 6.25 0.33 1.24e-9 White blood cell count (basophil);Basophil percentage of white cells; CRC cis rs1018836 0.923 rs10956749 chr8:91621573 G/A cg16814680 chr8:91681699 NA -0.77 -12.18 -0.56 1.96e-28 Ejection fraction in Tripanosoma cruzi seropositivity; CRC cis rs12973672 0.904 rs10424619 chr19:35768237 A/T cg12095397 chr19:35769544 USF2 0.47 6.04 0.32 4.1e-9 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs4727027 0.870 rs1534196 chr7:148790591 G/A cg12479418 chr7:148823350 ZNF425;ZNF398 0.45 6.0 0.31 5.08e-9 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC cis rs35146811 0.961 rs35991721 chr7:99728790 G/T cg13334819 chr7:99746414 C7orf59 -0.62 -8.08 -0.41 1.21e-14 Coronary artery disease; CRC cis rs1046896 0.586 rs9897951 chr17:80810662 T/C cg08200770 chr17:80723486 TBCD -0.49 -7.55 -0.38 4.43e-13 Glycated hemoglobin levels; CRC cis rs28386778 0.897 rs2727287 chr17:61904728 G/A cg23090583 chr17:61904693 PSMC5;FTSJ3 1.05 20.86 0.75 3.76e-62 Prudent dietary pattern; CRC cis rs4243830 0.571 rs60256927 chr1:6614747 G/A cg22792644 chr1:6614718 TAS1R1;NOL9 0.93 10.93 0.52 6.07e-24 Body mass index; CRC cis rs644799 0.710 rs564480 chr11:95561741 C/T cg25478527 chr11:95522999 CEP57;FAM76B 0.49 7.71 0.39 1.54e-13 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs864537 0.590 rs1214596 chr1:167427170 A/T cg09179987 chr1:167433047 CD247 -0.5 -7.4 -0.38 1.18e-12 Celiac disease or Rheumatoid arthritis;Celiac disease; CRC cis rs55882075 0.537 rs62406698 chr5:179110429 C/T cg14593053 chr5:179126677 CANX 0.51 7.52 0.38 5.25e-13 Monocyte percentage of white cells; CRC cis rs7333181 1.000 rs34631808 chr13:112236047 C/T cg27543320 chr13:112200689 NA 0.5 6.45 0.33 4.03e-10 Menopause (age at onset); CRC cis rs7737355 0.836 rs10900800 chr5:130914946 G/A cg25547332 chr5:131281432 NA 0.38 5.92 0.31 8.09e-9 Life satisfaction; CRC trans rs13221576 0.569 rs17166217 chr7:94011254 C/T cg25582398 chr5:1217743 SLC6A19 -0.55 -6.19 -0.32 1.81e-9 Intelligence; CRC trans rs11343 0.675 rs7359333 chr16:19262344 A/T cg22709453 chr3:122786502 PDIA5 -0.45 -5.97 -0.31 6.11e-9 Parkinson's disease; CRC cis rs10504229 0.815 rs16921955 chr8:58164553 C/T cg24829409 chr8:58192753 C8orf71 -0.59 -9.92 -0.48 1.87e-20 Developmental language disorder (linguistic errors); CRC cis rs853679 0.517 rs35227624 chr6:28132726 A/G cg15845792 chr6:28175446 NA 1.04 13.89 0.61 7.67e-35 Depression; CRC trans rs2303319 0.504 rs35304298 chr2:162617185 G/T cg10498984 chr16:28874827 SH2B1 -0.73 -6.28 -0.33 1.04e-9 Cognitive function; CRC cis rs1200821 0.529 rs2475206 chr10:37802532 A/G cg25427524 chr10:38739819 LOC399744 0.61 9.85 0.48 3.12e-20 Hemostatic factors and hematological phenotypes; CRC cis rs875971 0.522 rs6960048 chr7:65408039 A/G cg00343986 chr7:65444356 GUSB 0.56 8.62 0.43 2.92e-16 Aortic root size; CRC cis rs7274811 0.652 rs291686 chr20:32010851 T/C cg07470512 chr20:32255052 NECAB3;C20orf134 0.44 6.0 0.31 5.27e-9 Height; CRC cis rs12048904 0.619 rs10875346 chr1:101328083 T/C cg15686842 chr1:101360669 SLC30A7;EXTL2 0.6 8.11 0.41 9.79e-15 Multiple sclerosis; CRC cis rs933688 1.000 rs12655973 chr5:90736537 A/G cg02339078 chr5:90679543 LOC100129716;ARRDC3 0.91 14.91 0.63 9.29e-39 Smoking behavior; CRC cis rs7107174 0.901 rs2450137 chr11:77925233 C/G cg02023728 chr11:77925099 USP35 0.54 8.54 0.43 5e-16 Testicular germ cell tumor; CRC cis rs9303280 0.806 rs11078927 chr17:38064405 C/T cg11212589 chr17:38028394 ZPBP2 0.41 7.38 0.38 1.27e-12 Self-reported allergy; CRC cis rs172166 0.694 rs188105 chr6:28071393 C/T cg06470822 chr6:28175283 NA 0.82 12.25 0.56 1.14e-28 Cardiac Troponin-T levels; CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg08204369 chr17:73150733 HN1 -0.54 -6.53 -0.34 2.52e-10 Diisocyanate-induced asthma; CRC cis rs11190604 0.767 rs77838250 chr10:102180090 T/G cg16342193 chr10:102329863 NA -0.36 -5.86 -0.31 1.14e-8 Palmitoleic acid (16:1n-7) levels; CRC cis rs12497850 1.000 rs12497850 chr3:48748989 G/T cg20833759 chr3:49053208 WDR6;DALRD3 0.45 7.64 0.39 2.39e-13 Parkinson's disease; CRC cis rs4237845 0.537 rs12426201 chr12:58259752 C/T cg00677455 chr12:58241039 CTDSP2 0.82 12.07 0.55 5.08e-28 Intelligence (multi-trait analysis); CRC cis rs2456568 0.548 rs6483281 chr11:93661840 G/C cg26875233 chr11:93583750 C11orf90 -0.36 -6.9 -0.36 2.65e-11 Response to serotonin reuptake inhibitors in major depressive disorder; CRC cis rs2857891 0.650 rs2857928 chr11:6989721 C/G cg04053776 chr11:6947353 ZNF215 -0.41 -6.42 -0.33 4.82e-10 Response to cytadine analogues (cytosine arabinoside); CRC cis rs9916302 0.707 rs11078903 chr17:37631924 G/A cg03013999 chr17:37608204 MED1 0.44 6.63 0.34 1.35e-10 Glomerular filtration rate (creatinine); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg13887370 chr12:56224128 DNAJC14 0.44 6.25 0.33 1.25e-9 Intelligence (multi-trait analysis); CRC cis rs919433 0.926 rs12618567 chr2:198148191 A/T cg10820045 chr2:198174542 NA -0.53 -9.16 -0.45 5.52e-18 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg26859862 chr16:30389551 SEPT1 0.39 6.41 0.33 4.99e-10 Liver disease severity in Alagille syndrome; CRC cis rs4253772 0.530 rs9627387 chr22:46684678 A/G cg09491104 chr22:46646882 C22orf40 -0.37 -5.79 -0.3 1.62e-8 LDL cholesterol;Cholesterol, total; CRC cis rs6502050 0.835 rs28481866 chr17:80105160 G/A cg09264619 chr17:80180166 NA -0.34 -5.81 -0.3 1.5e-8 Life satisfaction; CRC trans rs1005277 0.579 rs2474586 chr10:38418882 T/C cg11292332 chr7:45801988 SEPT13 -0.35 -6.22 -0.32 1.47e-9 Extrinsic epigenetic age acceleration; CRC cis rs59043219 1 rs59043219 chr1:209970610 G/A cg22442454 chr1:209979470 IRF6 0.5 7.79 0.39 8.64e-14 Crohn's disease;Inflammatory bowel disease;Alzheimer's disease (APOE e4 interaction); CRC cis rs9914988 0.832 rs11650788 chr17:27174523 T/A cg20469991 chr17:27169893 C17orf63 -0.5 -5.94 -0.31 7.09e-9 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs77216612 0.877 rs72656645 chr12:12881055 A/G cg04607235 chr12:12878440 APOLD1 -1.03 -14.06 -0.61 1.76e-35 Lymphocyte counts; CRC cis rs798554 0.679 rs1639036 chr7:2885089 G/A cg19717773 chr7:2847554 GNA12 -0.39 -5.61 -0.3 4.24e-8 Height; CRC cis rs561341 0.505 rs28708703 chr17:30386845 C/G cg00745463 chr17:30367425 LRRC37B -0.69 -8.43 -0.42 1.08e-15 Hip circumference adjusted for BMI; CRC trans rs6762477 0.715 rs12631337 chr3:50198537 A/G cg21659725 chr3:3221576 CRBN -0.41 -6.12 -0.32 2.67e-9 Menarche (age at onset); CRC cis rs2204008 0.902 rs11520218 chr12:38223227 G/A cg13010199 chr12:38710504 ALG10B 0.45 5.73 0.3 2.23e-8 Bladder cancer; CRC cis rs1697139 0.583 rs1428475 chr5:66543954 G/T cg11553311 chr5:66541588 NA 0.58 9.84 0.48 3.36e-20 Breast cancer; CRC cis rs6484504 0.576 rs158146 chr11:31210433 G/A cg14844989 chr11:31128820 NA -0.34 -6.22 -0.32 1.54e-9 Red blood cell count; CRC cis rs2050392 0.517 rs603072 chr10:30755778 C/T cg25182066 chr10:30743637 MAP3K8 0.52 7.25 0.37 2.93e-12 Inflammatory bowel disease; CRC cis rs2836974 0.568 rs442972 chr21:40534757 C/T cg06238570 chr21:40685208 BRWD1 -0.79 -12.84 -0.58 7.27e-31 Cognitive function; CRC cis rs995000 0.868 rs11208007 chr1:63176083 A/T cg19896129 chr1:63156450 NA 0.4 5.78 0.3 1.72e-8 Triglyceride levels; CRC cis rs6502050 0.805 rs6502057 chr17:80082060 A/G cg25804541 chr17:80189381 SLC16A3 0.31 5.86 0.31 1.13e-8 Life satisfaction; CRC cis rs11864453 0.647 rs3764314 chr16:72127078 T/C cg23815491 chr16:72088622 HP 0.51 7.65 0.39 2.3e-13 Fibrinogen levels; CRC cis rs8141529 0.509 rs5762863 chr22:29253335 A/C cg15103426 chr22:29168792 CCDC117 0.55 7.58 0.39 3.44e-13 Lymphocyte counts; CRC trans rs1455244 0.665 rs9303735 chr18:11505086 C/T cg06024642 chr17:4510776 SMTNL2 -0.32 -6.09 -0.32 3.11e-9 Schizophrenia; CRC cis rs1008375 1.000 rs6811887 chr4:17640858 C/T cg02297831 chr4:17616191 MED28 0.46 6.15 0.32 2.19e-9 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs9828933 0.752 rs73117082 chr3:63947565 A/G cg16258503 chr3:63850278 ATXN7;THOC7 -0.81 -8.3 -0.42 2.65e-15 Type 2 diabetes; CRC cis rs798554 0.797 rs1182183 chr7:2873136 C/T cg19346786 chr7:2764209 NA -0.42 -7.4 -0.38 1.11e-12 Height; CRC cis rs1997103 1.000 rs4948012 chr7:55412578 A/C cg17469321 chr7:55412551 NA 0.74 11.73 0.54 8.65e-27 QRS interval (sulfonylurea treatment interaction); CRC cis rs2032447 0.772 rs199754 chr6:25992309 A/G cg12588279 chr6:26043732 HIST1H2BB 0.5 7.13 0.37 6.55e-12 Intelligence (multi-trait analysis); CRC cis rs2230307 0.536 rs564938 chr1:100592901 T/C cg24955406 chr1:100503596 HIAT1 -0.56 -6.7 -0.35 9.25e-11 Carotid intima media thickness; CRC cis rs9872999 1 rs9872999 chr3:133457514 C/T cg24879335 chr3:133465180 TF 0.49 9.7 0.47 9.74e-20 Iron status biomarkers; CRC cis rs780096 0.526 rs704791 chr2:27657167 T/C cg17158414 chr2:27665306 KRTCAP3 -0.31 -6.75 -0.35 6.85e-11 Total body bone mineral density; CRC cis rs6500602 0.647 rs1641868 chr16:4594503 G/C cg14951292 chr16:4525986 HMOX2;NMRAL1 0.52 7.87 0.4 5.12e-14 Schizophrenia; CRC cis rs1348850 0.554 rs1374438 chr2:178376684 A/G cg27490568 chr2:178487706 NA 0.57 7.07 0.36 9.44e-12 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs910316 0.673 rs2012627 chr14:75443103 C/T cg08847533 chr14:75593920 NEK9 0.84 14.57 0.63 1.88e-37 Height; CRC cis rs4665809 0.590 rs6749046 chr2:26429451 C/G cg27170947 chr2:26402098 FAM59B 0.6 7.84 0.4 6.24e-14 Gut microbiome composition (summer); CRC cis rs57590327 0.503 rs6764261 chr3:81620370 T/G cg07356753 chr3:81810745 GBE1 -0.54 -7.12 -0.37 6.94e-12 Extraversion; CRC cis rs9788682 1.000 rs61204066 chr15:78815298 G/A cg06917634 chr15:78832804 PSMA4 -0.48 -5.84 -0.31 1.25e-8 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; CRC cis rs501120 1.000 rs670056 chr10:44753375 C/T cg09554077 chr10:44749378 NA 0.89 13.32 0.59 1.14e-32 Coronary artery disease;Coronary heart disease; CRC cis rs4237845 0.844 rs4628718 chr12:58301600 A/C cg00677455 chr12:58241039 CTDSP2 0.6 8.4 0.42 1.4e-15 Intelligence (multi-trait analysis); CRC cis rs11758351 0.778 rs41266801 chr6:26197493 C/A cg22723502 chr6:26240528 HIST1H4F -0.38 -5.85 -0.31 1.18e-8 Gout;Renal underexcretion gout; CRC cis rs7615952 0.576 rs4646759 chr3:125822946 G/C cg04553112 chr3:125709451 NA -0.53 -6.1 -0.32 3.02e-9 Blood pressure (smoking interaction); CRC cis rs780096 0.506 rs1647265 chr2:27692261 A/G cg17158414 chr2:27665306 KRTCAP3 -0.3 -6.68 -0.35 9.98e-11 Total body bone mineral density; CRC cis rs4713118 0.662 rs149946 chr6:27970031 A/C cg12172441 chr6:28176163 NA -0.56 -7.48 -0.38 6.83e-13 Parkinson's disease; CRC cis rs10463316 0.894 rs7729438 chr5:150762197 G/A cg03212797 chr5:150827313 SLC36A1 -0.5 -7.78 -0.39 9.41e-14 Metabolite levels (Pyroglutamine); CRC cis rs694739 0.726 rs516124 chr11:64128423 G/T cg23796481 chr11:64053134 BAD;GPR137 0.47 6.85 0.35 3.65e-11 Alopecia areata;Crohn's disease;Psoriasis vulgaris; CRC trans rs10242455 0.702 rs73397499 chr7:99039627 T/C cg09045935 chr12:6379348 NA 1.14 8.99 0.44 1.99e-17 Blood metabolite levels; CRC trans rs1992950 1.000 rs10497836 chr2:200288718 C/T cg07934068 chr4:80883595 ANTXR2 0.43 6.61 0.34 1.58e-10 Ulcerative colitis; CRC cis rs875971 1.000 rs811880 chr7:65818646 T/C cg18876405 chr7:65276391 NA 0.53 9.12 0.45 7.62e-18 Aortic root size; CRC cis rs7208859 0.673 rs11656845 chr17:29206164 G/T cg14008862 chr17:28927542 LRRC37B2 0.55 5.73 0.3 2.22e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs853679 0.517 rs3757187 chr6:28107654 T/C cg03623178 chr6:28175578 NA 0.96 12.57 0.57 7.23e-30 Depression; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg08935602 chr16:2509817 C16orf59 0.51 6.53 0.34 2.44e-10 Thyroid stimulating hormone; CRC cis rs7255436 0.830 rs4350678 chr19:8447366 A/G cg16745616 chr19:8428856 ANGPTL4 -0.45 -7.04 -0.36 1.11e-11 HDL cholesterol; CRC cis rs73206853 0.563 rs7301623 chr12:111170903 T/C cg12870014 chr12:110450643 ANKRD13A 0.75 8.89 0.44 4.07e-17 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC cis rs713477 1.000 rs713477 chr14:55904426 C/A cg13175173 chr14:55914753 NA -0.45 -8.23 -0.41 4.53e-15 Pediatric bone mineral content (femoral neck); CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg12680326 chr20:2821316 VPS16;FAM113A -0.39 -6.34 -0.33 7.54e-10 Myopia (pathological); CRC cis rs2361718 0.603 rs12951255 chr17:78085597 A/G cg14949292 chr17:78079608 GAA -0.39 -6.12 -0.32 2.72e-9 Yeast infection; CRC cis rs10504229 0.636 rs72649133 chr8:58054681 G/A cg11062466 chr8:58055876 NA 0.59 7.23 0.37 3.38e-12 Developmental language disorder (linguistic errors); CRC trans rs12495832 0.778 rs79309301 chr3:147940024 T/A cg10221266 chr7:153579447 NA 0.59 6.34 0.33 7.77e-10 Chin dimples; CRC cis rs305851 0.875 rs9296304 chr6:39746879 A/G cg02386599 chr6:39769542 DAAM2 0.39 6.15 0.32 2.2e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs55871839 0.708 rs4738733 chr8:59813760 T/C cg07426533 chr8:59803705 TOX -0.34 -5.94 -0.31 7.22e-9 Pneumonia; CRC cis rs17001868 0.568 rs9611315 chr22:40736900 A/T cg07138101 chr22:40742427 ADSL 0.59 7.84 0.4 6.24e-14 Mammographic density (dense area); CRC cis rs1862618 0.853 rs1833896 chr5:56097669 C/A cg24531977 chr5:56204891 C5orf35 -0.77 -10.3 -0.49 9.5e-22 Initial pursuit acceleration; CRC cis rs6952808 1.000 rs6952808 chr7:1886535 C/G cg20295408 chr7:1910781 MAD1L1 -0.44 -6.39 -0.33 5.56e-10 Bipolar disorder and schizophrenia; CRC trans rs7395662 0.591 rs7483212 chr11:48607182 T/A cg03929089 chr4:120376271 NA -0.46 -6.42 -0.33 4.85e-10 HDL cholesterol; CRC cis rs3106136 0.967 rs13132963 chr4:95219780 A/G cg11021082 chr4:95130006 SMARCAD1 -0.46 -7.15 -0.37 5.64e-12 Capecitabine sensitivity; CRC cis rs1552244 0.572 rs59132826 chr3:10169725 G/A cg00166722 chr3:10149974 C3orf24 0.66 7.71 0.39 1.49e-13 Alzheimer's disease; CRC cis rs6499255 0.951 rs12232410 chr16:69736851 G/A cg00738113 chr16:70207722 CLEC18C -0.37 -5.77 -0.3 1.79e-8 IgE levels; CRC cis rs7147624 1.000 rs10135969 chr14:65982345 C/T cg03016385 chr14:66212404 NA -1.06 -10.9 -0.52 7.66e-24 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs5769765 0.908 rs9616390 chr22:50314289 G/C cg04121214 chr22:50244548 NA 0.41 5.8 0.3 1.54e-8 Schizophrenia; CRC cis rs7945705 0.902 rs10769979 chr11:9010659 C/T cg12365402 chr11:9010492 NRIP3 0.54 9.11 0.45 7.96e-18 Hemoglobin concentration; CRC trans rs11581859 0.950 rs7552573 chr1:99374181 A/C cg12183875 chr3:169587454 LRRC31 0.28 6.46 0.34 3.78e-10 Response to cognitive-behavioural therapy in anxiety disorder; CRC cis rs2032447 0.670 rs198820 chr6:26124243 G/A cg03517284 chr6:25882590 NA 0.41 5.64 0.3 3.6e-8 Intelligence (multi-trait analysis); CRC cis rs7945705 0.747 rs2653605 chr11:8993309 C/G cg21881798 chr11:8931708 C11orf17;ST5 -0.62 -10.74 -0.51 2.91e-23 Hemoglobin concentration; CRC cis rs3862030 0.720 rs7081110 chr10:104231651 A/G cg11453585 chr10:104263688 ACTR1A;SUFU -0.76 -13.31 -0.59 1.26e-32 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for body mass index; CRC cis rs7617773 0.780 rs4511916 chr3:48350366 G/A cg11946769 chr3:48343235 NME6 0.73 9.79 0.47 4.96e-20 Coronary artery disease; CRC cis rs9903692 0.954 rs9899461 chr17:46129353 A/G cg21215337 chr17:46176117 CBX1 -0.44 -7.97 -0.4 2.61e-14 Pulse pressure; CRC cis rs9311474 0.508 rs4687629 chr3:52615227 G/C cg05573699 chr3:52720067 GNL3;PBRM1 -0.47 -6.96 -0.36 1.9e-11 Electroencephalogram traits; CRC cis rs28386778 0.897 rs7221853 chr17:61859836 A/G cg22520471 chr17:61851767 DDX42;CCDC47 0.75 11.69 0.54 1.26e-26 Prudent dietary pattern; CRC cis rs8060686 0.641 rs76501820 chr16:68114582 G/A cg08314208 chr16:67682810 RLTPR -0.62 -6.61 -0.34 1.55e-10 HDL cholesterol;Metabolic syndrome; CRC cis rs6700896 0.931 rs7531867 chr1:66107546 A/G cg04111102 chr1:66153794 NA -0.32 -5.73 -0.3 2.3e-8 C-reactive protein;Mean corpuscular volume;Mean corpuscular hemoglobin; CRC cis rs2991971 1.000 rs518365 chr1:46010652 A/G cg24296786 chr1:45957014 TESK2 0.52 7.66 0.39 2.05e-13 High light scatter reticulocyte count; CRC cis rs77633900 0.614 rs2439993 chr15:76861532 G/A cg21673338 chr15:77095150 SCAPER -0.75 -7.64 -0.39 2.44e-13 Non-glioblastoma glioma;Glioma; CRC cis rs1707322 1.000 rs785480 chr1:46492164 C/G cg06784218 chr1:46089804 CCDC17 0.53 9.33 0.46 1.55e-18 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs7945705 0.935 rs2653567 chr11:8889630 T/C cg14711859 chr11:8959438 ASCL3 0.45 7.52 0.38 5.34e-13 Hemoglobin concentration; CRC cis rs10256972 0.516 rs12702081 chr7:1141528 T/C cg16145915 chr7:1198662 ZFAND2A -0.39 -7.57 -0.39 3.71e-13 Longevity;Endometriosis; CRC trans rs916888 0.773 rs199448 chr17:44809001 A/G cg07870213 chr5:140052090 DND1 1.01 11.55 0.54 3.95e-26 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs4750440 0.671 rs10796149 chr10:14025859 C/T cg00551146 chr10:14014579 FRMD4A 0.37 5.98 0.31 5.68e-9 Adiponectin levels; CRC cis rs12545109 0.800 rs1467126 chr8:57418452 C/T cg09654669 chr8:57350985 NA -0.45 -7.22 -0.37 3.69e-12 Obesity-related traits; CRC trans rs11098499 0.954 rs9998585 chr4:120396802 T/A cg25214090 chr10:38739885 LOC399744 0.65 10.37 0.5 5.42e-22 Corneal astigmatism; CRC cis rs1862618 0.525 rs2662021 chr5:56261691 C/T cg24531977 chr5:56204891 C5orf35 0.88 12.53 0.57 1.04e-29 Initial pursuit acceleration; CRC cis rs2840044 0.534 rs321596 chr17:33885736 C/T cg05299278 chr17:33885742 SLFN14 -0.52 -8.6 -0.43 3.42e-16 Response to radiotherapy in cancer (late toxicity); CRC cis rs2732480 0.500 rs1552550 chr12:48643351 C/A cg04545296 chr12:48745243 ZNF641 0.33 5.79 0.3 1.69e-8 Hemoglobin concentration;Red blood cell count;Hematocrit; CRC cis rs6860806 0.507 rs582490 chr5:131710095 G/A cg24060327 chr5:131705240 SLC22A5 0.54 8.01 0.4 2e-14 Breast cancer; CRC cis rs9322193 0.884 rs10872647 chr6:150079823 T/C cg07701084 chr6:150067640 NUP43 0.54 7.44 0.38 8.71e-13 Lung cancer; CRC cis rs9911578 0.835 rs9303398 chr17:56484257 T/C cg12560992 chr17:57184187 TRIM37 -0.84 -14.51 -0.62 3.33e-37 Intelligence (multi-trait analysis); CRC cis rs2070677 0.736 rs4498943 chr10:135422505 A/T cg16964102 chr10:135390573 NA -0.43 -5.73 -0.3 2.24e-8 Gout; CRC cis rs6460942 1.000 rs77010200 chr7:12290724 G/A cg20607287 chr7:12443886 VWDE -0.6 -6.07 -0.32 3.59e-9 Coronary artery disease; CRC cis rs651907 0.514 rs12636047 chr3:101434449 T/C cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.6 8.08 0.41 1.21e-14 Colorectal cancer; CRC cis rs9462846 0.887 rs2395938 chr6:42850659 C/A cg21280719 chr6:42927975 GNMT -0.3 -5.71 -0.3 2.52e-8 Blood protein levels; CRC cis rs10504229 0.593 rs12155520 chr8:58014318 C/T cg24829409 chr8:58192753 C8orf71 -0.54 -6.59 -0.34 1.75e-10 Developmental language disorder (linguistic errors); CRC cis rs11948739 0.576 rs11242051 chr5:130261276 G/A cg08523029 chr5:130500466 HINT1 0.49 6.25 0.33 1.25e-9 Pediatric bone mineral content (hip); CRC cis rs1008375 0.966 rs6837664 chr4:17697835 G/C cg16339924 chr4:17578868 LAP3 0.49 6.64 0.34 1.33e-10 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs11212617 0.869 rs4754299 chr11:108025214 C/T cg14761454 chr11:108092087 ATM;NPAT 0.39 5.83 0.31 1.3e-8 Response to metformin in type 2 diabetes (glycemic); CRC cis rs9467711 0.591 rs35335639 chr6:26038681 C/G cg08501292 chr6:25962987 TRIM38 0.84 8.08 0.41 1.25e-14 Autism spectrum disorder or schizophrenia; CRC cis rs9467773 0.935 rs11752946 chr6:26560364 C/A cg09904177 chr6:26538194 HMGN4 0.72 11.15 0.52 1.03e-24 Intelligence (multi-trait analysis); CRC cis rs7615952 0.534 rs1503072 chr3:125754691 C/T cg18479299 chr3:125709523 NA -0.54 -6.28 -0.33 1.04e-9 Blood pressure (smoking interaction); CRC cis rs4561483 0.549 rs6498251 chr16:11952290 A/G cg08843971 chr16:11963173 GSPT1 0.49 7.62 0.39 2.7e-13 Testicular germ cell tumor; CRC cis rs12135062 0.851 rs2651926 chr1:3101820 C/T cg21609526 chr1:3105151 PRDM16 -0.54 -9.32 -0.46 1.71e-18 Migraine; CRC cis rs6500602 0.929 rs6500603 chr16:4497537 G/C cg08645402 chr16:4508243 NA 0.57 9.44 0.46 7.1e-19 Schizophrenia; CRC cis rs6061231 0.837 rs6121558 chr20:60961365 A/G cg22601191 chr20:60968625 CABLES2 0.55 9.16 0.45 5.88e-18 Colorectal cancer; CRC cis rs2274273 0.967 rs8009670 chr14:55583477 G/A cg23234261 chr14:55582407 NA -0.3 -5.87 -0.31 1.07e-8 Protein biomarker; CRC cis rs950169 0.919 rs17300292 chr15:84762568 G/C cg17507749 chr15:85114479 UBE2QP1 0.77 11.96 0.55 1.27e-27 Schizophrenia; CRC trans rs2303319 0.504 rs62188988 chr2:162531068 T/C cg10498984 chr16:28874827 SH2B1 -0.71 -6.11 -0.32 2.86e-9 Cognitive function; CRC cis rs483180 0.855 rs562038 chr1:120254545 G/C cg19096424 chr1:120255104 PHGDH 0.57 7.58 0.39 3.45e-13 Macular telangiectasia type 2; CRC cis rs4919694 0.908 rs11191523 chr10:104792400 A/G cg04362960 chr10:104952993 NT5C2 1.17 10.78 0.51 2.08e-23 Arsenic metabolism; CRC cis rs73206853 0.764 rs3026468 chr12:110758081 T/A cg12870014 chr12:110450643 ANKRD13A 0.8 7.76 0.39 1.1e-13 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC cis rs4713118 0.629 rs149899 chr6:28019979 C/T cg02683197 chr6:28174875 NA 0.73 9.78 0.47 5.29e-20 Parkinson's disease; CRC cis rs1862618 0.853 rs863840 chr5:56128999 C/G cg18230493 chr5:56204884 C5orf35 -0.69 -8.95 -0.44 2.73e-17 Initial pursuit acceleration; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg03367560 chr6:126307401 TRMT11 0.43 6.3 0.33 9.57e-10 Intelligence (multi-trait analysis); CRC cis rs8105895 0.935 rs28635943 chr19:22268712 G/T cg02657401 chr19:22469223 NA -0.34 -5.83 -0.31 1.33e-8 Body mass index (change over time); CRC cis rs7107174 1.000 rs2511178 chr11:77923220 C/T cg02023728 chr11:77925099 USP35 0.52 7.8 0.4 8.25e-14 Testicular germ cell tumor; CRC cis rs6840360 0.615 rs9996320 chr4:152610587 T/G cg09659197 chr4:152720779 NA 0.42 8.5 0.42 6.86e-16 Intelligence (multi-trait analysis); CRC cis rs79349575 0.783 rs4793991 chr17:47001801 A/G cg22482690 chr17:47019901 SNF8 0.48 8.03 0.41 1.7e-14 Type 2 diabetes; CRC cis rs3096299 0.566 rs4129126 chr16:89561475 A/C cg05320533 chr16:89541815 ANKRD11 -0.43 -5.95 -0.31 6.98e-9 Multiple myeloma (IgH translocation); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg05793409 chr1:35658810 SFPQ 0.53 7.74 0.39 1.21e-13 Response to antipsychotic treatment; CRC cis rs7959452 0.590 rs11177644 chr12:69785748 A/G cg20891283 chr12:69753455 YEATS4 0.89 16.16 0.67 1.17e-43 Blood protein levels; CRC cis rs7666738 0.861 rs28829607 chr4:98964325 G/C cg05340658 chr4:99064831 C4orf37 0.61 9.45 0.46 6.55e-19 Colonoscopy-negative controls vs population controls; CRC cis rs2227564 0.649 rs2243610 chr10:75601653 A/T cg00564723 chr10:75632066 CAMK2G -0.37 -8.83 -0.44 6.36e-17 Crohn's disease;Inflammatory bowel disease; CRC trans rs7618501 0.633 rs9861216 chr3:50059339 A/G cg21665057 chr3:196295764 WDR53;FBXO45 -0.58 -9.25 -0.45 2.97e-18 Intelligence (multi-trait analysis); CRC cis rs425277 0.585 rs364677 chr1:2071765 A/G cg24578937 chr1:2090814 PRKCZ -0.38 -6.94 -0.36 2.14e-11 Height; CRC cis rs3736594 0.959 rs10209020 chr2:27980944 C/T cg27432699 chr2:27873401 GPN1 -0.61 -8.33 -0.42 2.2e-15 Fasting blood glucose;Fasting blood glucose (BMI interaction); CRC cis rs4319547 0.695 rs11836188 chr12:122865507 T/C cg23029597 chr12:123009494 RSRC2 0.61 7.46 0.38 7.81e-13 Body mass index; CRC cis rs6586163 0.843 rs7069061 chr10:90754909 A/G cg03111039 chr10:90751583 FAS;ACTA2 -0.5 -7.33 -0.37 1.74e-12 Chronic lymphocytic leukemia; CRC cis rs7258465 1.000 rs28572537 chr19:18552208 C/T cg06462663 chr19:18546047 ISYNA1 0.47 6.9 0.36 2.67e-11 Breast cancer; CRC cis rs35306767 0.714 rs7072554 chr10:1090988 C/T cg20503657 chr10:835505 NA 0.62 8.4 0.42 1.34e-15 Eosinophil percentage of granulocytes; CRC cis rs6860806 0.507 rs270606 chr5:131650867 A/G cg02033258 chr5:131593261 PDLIM4 0.4 6.7 0.35 8.97e-11 Breast cancer; CRC cis rs9303401 0.659 rs34170300 chr17:56789905 G/C cg10487724 chr17:56770010 TEX14;RAD51C 0.79 10.0 0.48 1.01e-20 Cognitive test performance; CRC cis rs4919694 1.000 rs12242000 chr10:104702413 A/C cg04362960 chr10:104952993 NT5C2 1.11 10.4 0.5 4.45e-22 Arsenic metabolism; CRC cis rs9911578 0.692 rs411988 chr17:56709034 G/A cg05425664 chr17:57184151 TRIM37 -0.41 -6.27 -0.33 1.17e-9 Intelligence (multi-trait analysis); CRC cis rs4665809 1.000 rs7599132 chr2:26279810 A/T cg22920501 chr2:26401640 FAM59B 0.55 7.69 0.39 1.73e-13 Gut microbiome composition (summer); CRC cis rs9733 0.526 rs11204696 chr1:150658721 T/C cg18016565 chr1:150552671 MCL1 0.47 6.82 0.35 4.33e-11 Tonsillectomy; CRC cis rs4713118 0.512 rs2622319 chr6:28120401 G/C cg02683197 chr6:28174875 NA 0.7 9.74 0.47 7.45e-20 Parkinson's disease; CRC cis rs853679 0.517 rs4713135 chr6:28039586 G/A cg23161317 chr6:28129485 ZNF389 0.53 6.52 0.34 2.57e-10 Depression; CRC cis rs208520 0.802 rs208496 chr6:66930786 G/C cg07460842 chr6:66804631 NA -0.95 -12.39 -0.56 3.37e-29 Exhaled nitric oxide output; CRC cis rs796364 0.951 rs769952 chr2:200734368 C/T cg12253985 chr2:200820533 C2orf60;C2orf47 0.59 6.54 0.34 2.31e-10 Schizophrenia; CRC cis rs9399137 0.561 rs11753985 chr6:135280438 C/T cg22676075 chr6:135203613 NA 0.6 8.93 0.44 2.99e-17 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; CRC cis rs3106136 0.527 rs2632410 chr4:95149507 A/T cg11021082 chr4:95130006 SMARCAD1 -0.6 -9.51 -0.46 4.16e-19 Capecitabine sensitivity; CRC cis rs7737355 0.947 rs6883034 chr5:130920415 T/C cg06307176 chr5:131281290 NA 0.5 7.05 0.36 1.04e-11 Life satisfaction; CRC cis rs1577917 0.771 rs2484355 chr6:86394403 C/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.67 -9.3 -0.46 2.05e-18 Response to antipsychotic treatment; CRC trans rs2303319 0.504 rs62187612 chr2:162432494 A/G cg10498984 chr16:28874827 SH2B1 -0.73 -5.97 -0.31 6.13e-9 Cognitive function; CRC cis rs1799949 0.501 rs2343819 chr17:41409653 T/G cg19454999 chr17:41278357 BRCA1;NBR2 0.52 8.15 0.41 7.64e-15 Menopause (age at onset); CRC cis rs11122272 0.735 rs2486733 chr1:231531465 C/T cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.58 -8.72 -0.43 1.37e-16 Hemoglobin concentration; CRC cis rs10504229 0.610 rs6999661 chr8:58127391 C/G cg02725872 chr8:58115012 NA -0.64 -11.55 -0.54 3.85e-26 Developmental language disorder (linguistic errors); CRC cis rs11677416 1.000 rs6542090 chr2:113524795 T/C cg06156847 chr2:113672199 IL1F7 -0.4 -6.03 -0.32 4.38e-9 Response to antipsychotic treatment in schizophrenia (working memory); CRC cis rs9322193 0.923 rs9371199 chr6:150138662 A/T cg13206674 chr6:150067644 NUP43 0.67 9.25 0.45 2.84e-18 Lung cancer; CRC cis rs7412746 0.658 rs12067685 chr1:150952917 T/C cg15448220 chr1:150897856 SETDB1 0.55 7.83 0.4 6.6e-14 Melanoma; CRC cis rs10540 1.000 rs35874808 chr11:506442 G/T cg15790184 chr11:494944 RNH1 0.61 6.27 0.33 1.14e-9 Body mass index; CRC cis rs2739330 0.828 rs2877178 chr22:24251517 C/T cg11905131 chr22:24372483 LOC391322 -0.72 -11.41 -0.53 1.24e-25 Liver enzyme levels (gamma-glutamyl transferase); CRC trans rs877282 0.945 rs11599043 chr10:777972 C/T cg22713356 chr15:30763199 NA 1.19 14.94 0.64 6.8e-39 Uric acid levels; CRC cis rs4927850 0.752 rs7618864 chr3:195749561 G/A cg01181863 chr3:195395398 SDHAP2 -0.67 -9.9 -0.48 2.19e-20 Pancreatic cancer; CRC cis rs34779708 0.868 rs2384352 chr10:35492832 A/G cg03585969 chr10:35415529 CREM 0.49 6.37 0.33 6.2e-10 Inflammatory bowel disease;Crohn's disease; CRC cis rs589448 0.535 rs12423794 chr12:69713018 G/A cg14784868 chr12:69753453 YEATS4 0.77 12.35 0.56 4.71e-29 Cerebrospinal fluid biomarker levels; CRC cis rs6662572 0.737 rs72677550 chr1:46589276 G/C cg08644498 chr1:46502608 NA 0.42 6.56 0.34 2.15e-10 Blood protein levels; CRC cis rs1799949 1.000 rs11657053 chr17:41191129 G/T cg23758822 chr17:41437982 NA 0.8 13.18 0.59 3.91e-32 Menopause (age at onset); CRC cis rs4713118 0.786 rs200503 chr6:27785882 A/G cg20933634 chr6:27740509 NA 0.62 8.21 0.41 5.17e-15 Parkinson's disease; CRC cis rs4332037 0.539 rs55993248 chr7:2071132 A/G cg21155852 chr7:2048760 MAD1L1 -0.5 -6.8 -0.35 5.02e-11 Bipolar disorder; CRC trans rs11098499 0.874 rs10022508 chr4:120115228 A/G cg25214090 chr10:38739885 LOC399744 0.52 7.71 0.39 1.48e-13 Corneal astigmatism; CRC cis rs9549260 0.564 rs4941990 chr13:41299857 A/C cg21288729 chr13:41239152 FOXO1 0.42 6.58 0.34 1.82e-10 Red blood cell count; CRC cis rs270601 0.690 rs162904 chr5:131595784 C/T cg18301423 chr5:131593218 PDLIM4 -0.43 -7.44 -0.38 8.67e-13 Acylcarnitine levels; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg11717700 chr4:154387421 KIAA0922 0.46 6.51 0.34 2.85e-10 Anxiety disorder; CRC cis rs4253772 0.530 rs6008616 chr22:46707954 A/G cg03482458 chr22:46692211 CN5H6.4;GTSE1 0.5 6.15 0.32 2.26e-9 LDL cholesterol;Cholesterol, total; CRC cis rs11122272 0.735 rs1076804 chr1:231498460 T/C cg06096015 chr1:231504339 EGLN1 0.39 6.0 0.31 5.32e-9 Hemoglobin concentration; CRC trans rs59888335 1.000 rs60381750 chr3:80752104 G/T cg10129408 chr6:10421001 TFAP2A 0.38 6.02 0.31 4.57e-9 Schizophrenia; CRC cis rs754466 1.000 rs754466 chr10:79680434 A/T cg17075019 chr10:79541650 NA -0.7 -9.73 -0.47 8.09e-20 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs9733 0.570 rs951281 chr1:150691122 A/C cg18016565 chr1:150552671 MCL1 0.45 6.52 0.34 2.57e-10 Tonsillectomy; CRC cis rs2070488 1.000 rs4147024 chr3:38456664 C/T cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.9 16.19 0.67 9.15e-44 Electrocardiographic conduction measures; CRC cis rs1801251 1.000 rs13003675 chr2:233584109 C/T cg25237894 chr2:233734115 C2orf82 0.54 8.72 0.43 1.35e-16 Coronary artery disease; CRC cis rs9311474 0.581 rs13621 chr3:52558133 T/C cg07507251 chr3:52567010 NT5DC2 0.47 7.27 0.37 2.68e-12 Electroencephalogram traits; CRC cis rs7552404 0.655 rs1146646 chr1:76265500 G/A cg10523679 chr1:76189770 ACADM 0.69 9.48 0.46 5.35e-19 Blood metabolite levels;Acylcarnitine levels; CRC cis rs78456975 1.000 rs6712176 chr2:1556393 C/T cg01028140 chr2:1542097 TPO -0.55 -5.74 -0.3 2.15e-8 Placebo response in major depressive disorder (% change in symptom score); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg24589564 chr2:27357686 PREB 0.44 6.37 0.33 6.19e-10 Intelligence (multi-trait analysis); CRC trans rs7613875 0.580 rs11709503 chr3:49991167 G/T cg21665057 chr3:196295764 WDR53;FBXO45 0.43 6.25 0.33 1.28e-9 Body mass index; CRC cis rs72781680 0.716 rs2712056 chr2:23959131 C/T cg08917208 chr2:24149416 ATAD2B 0.57 6.49 0.34 3.13e-10 Lymphocyte counts; CRC cis rs172166 0.611 rs203883 chr6:28078356 A/G cg03623178 chr6:28175578 NA 0.79 11.41 0.53 1.22e-25 Cardiac Troponin-T levels; CRC cis rs1448094 0.511 rs10863079 chr12:86152700 T/A cg06740227 chr12:86229804 RASSF9 -0.38 -5.78 -0.3 1.74e-8 Major depressive disorder; CRC cis rs17433780 0.897 rs12120863 chr1:89501522 T/C cg09516651 chr1:89888402 LOC400759 0.48 7.34 0.38 1.68e-12 Carotid intima media thickness; CRC cis rs10901296 0.660 rs2855197 chr9:133764406 A/G cg01000188 chr9:133769184 QRFP 0.62 7.82 0.4 7.42e-14 Bilirubin levels; CRC cis rs763121 0.853 rs6001204 chr22:39100239 T/C cg06022373 chr22:39101656 GTPBP1 0.82 13.67 0.6 5.5e-34 Menopause (age at onset); CRC cis rs1552244 0.810 rs6809572 chr3:10100145 G/A cg18598329 chr3:10140678 FANCD2;C3orf24 -0.87 -11.82 -0.55 4.24e-27 Alzheimer's disease; CRC cis rs3749237 0.595 rs11130199 chr3:49538799 T/C cg07636037 chr3:49044803 WDR6 0.54 8.03 0.4 1.74e-14 Resting heart rate; CRC cis rs2223471 0.967 rs3765306 chr6:50712784 C/T cg03432817 chr6:50765336 NA -0.41 -6.65 -0.34 1.26e-10 Subcutaneous adipose tissue; CRC cis rs10504229 0.906 rs61638902 chr8:58193511 A/C cg22535103 chr8:58192502 C8orf71 -0.69 -10.76 -0.51 2.48e-23 Developmental language disorder (linguistic errors); CRC cis rs11203032 0.831 rs11203018 chr10:90948783 T/C cg16672925 chr10:90967113 CH25H 0.46 5.79 0.3 1.66e-8 Heart failure; CRC cis rs9611565 0.694 rs9607816 chr22:41950897 G/A cg06481639 chr22:41940642 POLR3H -0.52 -6.12 -0.32 2.65e-9 Vitiligo; CRC cis rs2976388 1.000 rs2978982 chr8:143763490 T/C cg24046110 chr8:143859143 LYNX1 -0.37 -6.43 -0.33 4.57e-10 Urinary tract infection frequency; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg26433777 chr5:178157346 ZNF354A 0.38 6.06 0.32 3.66e-9 Liver disease severity in Alagille syndrome; CRC cis rs1949733 1.000 rs6447875 chr4:8503206 T/C cg13073564 chr4:8508604 NA -0.5 -7.46 -0.38 7.74e-13 Response to antineoplastic agents; CRC trans rs2727020 0.658 rs4980440 chr11:49386017 C/T cg11707556 chr5:10655725 ANKRD33B -0.38 -7.18 -0.37 4.69e-12 Coronary artery disease; CRC cis rs6543140 0.964 rs6543144 chr2:103092575 A/G cg09003973 chr2:102972529 NA 0.42 5.84 0.31 1.23e-8 Blood protein levels; CRC cis rs941408 0.515 rs4624312 chr19:2774460 T/C cg06609049 chr19:2785107 THOP1 1.04 17.34 0.69 2.58e-48 Total cholesterol levels; CRC cis rs6964587 0.967 rs10231350 chr7:91808499 G/T cg17063962 chr7:91808500 NA 0.87 15.24 0.64 4.63e-40 Breast cancer; CRC cis rs7615952 0.599 rs12496921 chr3:125701948 C/G cg05084668 chr3:125655381 ALG1L -0.46 -6.55 -0.34 2.18e-10 Blood pressure (smoking interaction); CRC cis rs1218582 0.682 rs12144978 chr1:154850445 G/A cg12436631 chr1:155007014 DCST1;DCST2 0.37 5.94 0.31 7.25e-9 Prostate cancer; CRC cis rs1448094 0.556 rs11614513 chr12:86167756 G/C cg25456477 chr12:86230367 RASSF9 0.4 6.71 0.35 8.75e-11 Major depressive disorder; CRC cis rs17253792 0.732 rs79014965 chr14:56117551 T/G cg01858014 chr14:56050164 KTN1 -0.87 -7.23 -0.37 3.31e-12 Putamen volume; CRC cis rs7584330 0.554 rs77380873 chr2:238426551 C/T cg14458575 chr2:238380390 NA 0.8 9.9 0.48 2.09e-20 Prostate cancer; CRC cis rs2932538 0.961 rs12126494 chr1:113228623 G/A cg22162597 chr1:113214053 CAPZA1 0.64 8.54 0.43 5.21e-16 Systolic blood pressure;Diastolic blood pressure;Hypertension;Blood pressure; CRC cis rs6964587 0.869 rs10278155 chr7:91532456 T/G cg17063962 chr7:91808500 NA -0.74 -12.39 -0.56 3.53e-29 Breast cancer; CRC cis rs6693567 0.565 rs698913 chr1:150299145 G/A cg15654264 chr1:150340011 RPRD2 0.37 5.81 0.31 1.46e-8 Migraine; CRC cis rs9875589 0.509 rs9824910 chr3:14040136 C/T cg14375111 chr3:14165186 TMEM43;CHCHD4 0.4 5.85 0.31 1.16e-8 Ovarian reserve; CRC trans rs2303319 0.504 rs56965753 chr2:162597251 A/G cg18122310 chr12:50236657 BCDIN3D -0.73 -6.35 -0.33 7.23e-10 Cognitive function; CRC trans rs8073060 0.586 rs225305 chr17:33921160 C/T cg19694781 chr19:47549865 TMEM160 -0.98 -13.52 -0.6 1.94e-33 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; CRC cis rs2882667 0.931 rs10038799 chr5:138362283 C/T cg09476006 chr5:138032270 NA 0.44 7.42 0.38 1.01e-12 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs6570726 0.846 rs7762536 chr6:145923145 T/C cg23711669 chr6:146136114 FBXO30 0.68 11.48 0.53 7.22e-26 Lobe attachment (rater-scored or self-reported); CRC cis rs449789 0.524 rs2879852 chr6:159748036 C/T cg14500486 chr6:159655392 FNDC1 -0.46 -7.0 -0.36 1.41e-11 Pulse pressure; CRC cis rs208520 0.909 rs55813840 chr6:67012508 A/C cg07460842 chr6:66804631 NA 0.84 9.91 0.48 1.91e-20 Exhaled nitric oxide output; CRC cis rs3823572 0.542 rs62470438 chr7:133625504 A/G cg03336402 chr7:133662267 EXOC4 0.67 10.05 0.48 6.82e-21 Intelligence (multi-trait analysis); CRC cis rs216303 0.570 rs216321 chr12:6143984 T/C cg19878637 chr12:6148451 VWF -0.64 -6.96 -0.36 1.87e-11 Low vWF levels; CRC cis rs2288073 0.896 rs13404513 chr2:24410780 G/A cg06627628 chr2:24431161 ITSN2 -0.72 -9.69 -0.47 1.09e-19 Venous thromboembolism (SNP x SNP interaction); CRC cis rs9486719 1.000 rs12190508 chr6:96898269 T/C cg06623918 chr6:96969491 KIAA0776 -0.81 -9.47 -0.46 5.55e-19 Migraine;Coronary artery disease; CRC cis rs3785574 0.962 rs2665840 chr17:61873307 C/T cg25654072 chr17:61904446 PSMC5;FTSJ3 -0.43 -6.04 -0.32 4.14e-9 Height; CRC cis rs8180040 0.764 rs4082155 chr3:47125385 G/A cg27129171 chr3:47204927 SETD2 0.69 11.19 0.53 7.51e-25 Colorectal cancer; CRC cis rs7412746 0.658 rs59988025 chr1:150940358 C/T cg10589385 chr1:150898437 SETDB1 0.33 6.98 0.36 1.68e-11 Melanoma; CRC cis rs12926788 0.546 rs200531 chr16:24756172 G/A cg06505273 chr16:24850292 NA -0.52 -6.73 -0.35 7.64e-11 Ejection fraction in Tripanosoma cruzi seropositivity; CRC cis rs1707322 1.000 rs10789485 chr1:46407308 C/T cg06784218 chr1:46089804 CCDC17 0.59 10.62 0.51 7.68e-23 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs11577318 0.853 rs3795684 chr1:26632781 C/T cg00852783 chr1:26633632 UBXN11 0.49 6.96 0.36 1.9e-11 Granulocyte percentage of myeloid white cells; CRC cis rs875971 0.862 rs1875057 chr7:65731855 A/G cg11764359 chr7:65958608 NA -0.58 -8.61 -0.43 3.09e-16 Aortic root size; CRC cis rs7666738 0.761 rs1456210 chr4:98645932 T/G cg05340658 chr4:99064831 C4orf37 0.56 8.45 0.42 9.58e-16 Colonoscopy-negative controls vs population controls; CRC cis rs9372498 0.536 rs9489407 chr6:118792337 A/T cg15382696 chr6:118971807 C6orf204 -0.59 -7.77 -0.39 1.02e-13 Diastolic blood pressure; CRC cis rs881375 0.631 rs10739577 chr9:123668854 C/T cg09419670 chr9:123605666 PSMD5;LOC253039 0.51 8.11 0.41 9.95e-15 Rheumatoid arthritis; CRC cis rs12898370 0.641 rs11632999 chr15:77436995 T/G cg10437265 chr15:77819839 NA 0.55 7.55 0.38 4.35e-13 Risky sexual behaviors (alcohol dependence interaction); CRC cis rs7829975 0.871 rs777709 chr8:8583872 T/C cg06636001 chr8:8085503 FLJ10661 -0.58 -9.26 -0.45 2.8e-18 Mood instability; CRC cis rs9309473 0.607 rs10196402 chr2:73572081 A/C cg20560298 chr2:73613845 ALMS1 -0.5 -6.64 -0.34 1.3e-10 Metabolite levels; CRC cis rs4665809 0.590 rs1122972 chr2:26418788 A/C cg27170947 chr2:26402098 FAM59B -0.59 -7.62 -0.39 2.79e-13 Gut microbiome composition (summer); CRC trans rs7726839 0.540 rs11739847 chr5:609661 G/A cg25482853 chr8:67687455 SGK3 1.1 12.9 0.58 4.37e-31 Obesity-related traits; CRC cis rs2730245 1.000 rs2527199 chr7:158737113 G/A cg24397884 chr7:158709396 WDR60 -0.95 -16.37 -0.67 1.74e-44 Height; CRC cis rs9649213 0.593 rs1132971 chr7:97921533 A/G cg24562669 chr7:97807699 LMTK2 0.45 7.54 0.38 4.56e-13 Prostate cancer (SNP x SNP interaction); CRC cis rs12908161 1.000 rs12905057 chr15:85210765 A/G cg11189052 chr15:85197271 WDR73 0.62 8.86 0.44 5.29e-17 Schizophrenia; CRC cis rs7605827 0.930 rs3792578 chr2:15534642 G/A cg19274914 chr2:15703543 NA 0.39 5.87 0.31 1.06e-8 Educational attainment (years of education); CRC cis rs3820068 0.581 rs12385690 chr1:15932932 A/T cg13390004 chr1:15929781 NA 0.5 7.08 0.36 8.51e-12 Systolic blood pressure; CRC cis rs1797081 1.000 rs2603807 chr10:16872797 A/G cg23933602 chr10:16859644 RSU1 1.05 20.5 0.75 9.74e-61 Platelet distribution width; CRC trans rs10504229 0.953 rs75585481 chr8:58192202 T/C cg04077850 chr5:125800366 GRAMD3 0.37 6.27 0.33 1.15e-9 Developmental language disorder (linguistic errors); CRC cis rs4862750 0.872 rs7671914 chr4:187878165 A/G cg07414643 chr4:187882934 NA 0.43 7.61 0.39 2.84e-13 Lobe attachment (rater-scored or self-reported); CRC cis rs4665809 1.000 rs6729080 chr2:26301282 G/A cg25036284 chr2:26402008 FAM59B -0.46 -6.03 -0.32 4.3e-9 Gut microbiome composition (summer); CRC cis rs11719291 0.504 rs71324924 chr3:48865444 G/A cg07636037 chr3:49044803 WDR6 -0.82 -6.75 -0.35 6.8e-11 Cognitive function; CRC trans rs11039798 1.000 rs115429994 chr11:48761183 C/G cg03929089 chr4:120376271 NA 0.63 6.06 0.32 3.73e-9 Axial length; CRC cis rs2286885 1.000 rs10733677 chr9:129242209 A/G cg15282417 chr9:129245246 FAM125B 0.44 7.86 0.4 5.69e-14 Intraocular pressure; CRC cis rs1552244 0.832 rs73024591 chr3:10203194 A/T cg16606324 chr3:10149918 C3orf24 0.61 6.83 0.35 4.15e-11 Alzheimer's disease; CRC cis rs6570726 0.935 rs380883 chr6:145822992 A/G cg23711669 chr6:146136114 FBXO30 0.68 11.65 0.54 1.7e-26 Lobe attachment (rater-scored or self-reported); CRC cis rs911555 0.723 rs6575982 chr14:103862681 G/A cg24130564 chr14:104152367 KLC1 0.42 5.67 0.3 3.08e-8 Intelligence (multi-trait analysis); CRC cis rs1559088 0.522 rs7254912 chr19:33554151 A/G cg27124370 chr19:33622961 WDR88 0.47 7.06 0.36 1.02e-11 Bone ultrasound measurement (broadband ultrasound attenuation); CRC cis rs6495122 0.501 rs12904227 chr15:75387048 A/C cg09165964 chr15:75287851 SCAMP5 -0.5 -7.75 -0.39 1.16e-13 Caffeine consumption;Diastolic blood pressure;Coffee consumption; CRC cis rs763014 0.966 rs12935215 chr16:670605 T/C cg18653534 chr16:772142 FAM173A -0.37 -5.9 -0.31 9.18e-9 Height; CRC cis rs2806561 0.929 rs10917357 chr1:23535161 C/T cg19743168 chr1:23544995 NA 0.39 6.06 0.32 3.77e-9 Height; CRC cis rs2070488 1.000 rs36006749 chr3:38443312 T/C cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.87 15.88 0.66 1.56e-42 Electrocardiographic conduction measures; CRC cis rs6694672 0.717 rs10801588 chr1:197062923 T/C cg13682187 chr1:196946512 CFHR5 0.43 6.97 0.36 1.74e-11 Asthma; CRC cis rs17376456 0.825 rs66564678 chr5:93165894 C/T cg21475434 chr5:93447410 FAM172A 0.71 7.03 0.36 1.2e-11 Diabetic retinopathy; CRC cis rs12692738 0.526 rs355869 chr2:165631397 C/T cg03182029 chr2:165697222 COBLL1 0.5 5.86 0.31 1.11e-8 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);Waist-to-hip ratio adjusted for BMI in non-smokers;Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction);Waist-to-hip ratio adjusted for body mass index; CRC cis rs7635838 0.892 rs3942925 chr3:11442921 T/C cg00170343 chr3:11313890 ATG7 0.42 6.4 0.33 5.47e-10 HDL cholesterol; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg06505121 chr5:1038489 NKD2 0.39 6.12 0.32 2.66e-9 Liver disease severity in Alagille syndrome; CRC trans rs2303319 0.504 rs62187612 chr2:162432494 A/G cg09481857 chr22:21368659 P2RX6;MGC16703 -0.66 -6.16 -0.32 2.08e-9 Cognitive function; CRC cis rs694739 1.000 rs694739 chr11:64097233 A/G cg23796481 chr11:64053134 BAD;GPR137 0.57 8.51 0.42 6.03e-16 Alopecia areata;Crohn's disease;Psoriasis vulgaris; CRC cis rs10791097 1.000 rs10791098 chr11:130718711 T/G cg12179176 chr11:130786555 SNX19 0.57 8.87 0.44 4.72e-17 Autism spectrum disorder or schizophrenia;Schizophrenia; CRC cis rs561341 0.609 rs7214626 chr17:30190989 G/A cg00745463 chr17:30367425 LRRC37B 0.54 6.64 0.34 1.34e-10 Hip circumference adjusted for BMI; CRC cis rs2565722 0.665 rs9347466 chr6:161297926 A/T cg03159191 chr6:161285451 NA -0.46 -6.4 -0.33 5.47e-10 Blood protein levels; CRC cis rs7927592 0.830 rs10896339 chr11:68302846 G/C cg16797656 chr11:68205561 LRP5 0.39 6.49 0.34 3.21e-10 Total body bone mineral density; CRC cis rs1570884 0.536 rs1359541 chr13:50158939 A/G cg03651054 chr13:50194643 NA 0.33 6.81 0.35 4.71e-11 Sum basophil neutrophil counts;Sum neutrophil eosinophil counts;Neutrophil count;Myeloid white cell count;Granulocyte count; CRC cis rs877282 0.945 rs34367686 chr10:791868 G/C cg17470449 chr10:769945 NA 0.68 9.03 0.45 1.48e-17 Uric acid levels; CRC cis rs9837602 0.935 rs9810235 chr3:99736538 C/T cg07805332 chr3:99536008 MIR548G;C3orf26 -0.49 -6.37 -0.33 6.39e-10 Breast cancer; CRC cis rs7811142 0.943 rs67483801 chr7:100031758 G/T cg00814883 chr7:100076585 TSC22D4 -0.7 -9.25 -0.45 2.94e-18 Platelet count; CRC cis rs2032447 0.765 rs6942072 chr6:26014987 A/G cg03517284 chr6:25882590 NA -0.5 -6.97 -0.36 1.7e-11 Intelligence (multi-trait analysis); CRC trans rs3733585 0.699 rs17245723 chr4:9962218 A/T cg26043149 chr18:55253948 FECH -0.5 -7.62 -0.39 2.66e-13 Cleft plate (environmental tobacco smoke interaction); CRC cis rs11212617 1.000 rs10431060 chr11:108288228 A/C cg01991180 chr11:108092276 ATM;NPAT 0.4 5.8 0.3 1.59e-8 Response to metformin in type 2 diabetes (glycemic); CRC cis rs4629710 0.592 rs11759793 chr6:131546384 G/A cg12606694 chr6:131520996 AKAP7 0.56 8.36 0.42 1.85e-15 Multiple myeloma (IgH translocation); CRC cis rs7428 0.527 rs7608892 chr2:85542718 G/A cg24342717 chr2:85555507 TGOLN2 -0.79 -13.39 -0.59 6.41e-33 Ear protrusion; CRC cis rs1008375 1.000 rs4642241 chr4:17617111 T/C cg04450456 chr4:17643702 FAM184B 0.41 6.58 0.34 1.9e-10 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs6834538 0.520 rs34916940 chr4:113421609 C/T cg10021238 chr4:113569128 MIR367;LARP7 -0.37 -5.8 -0.3 1.55e-8 Free thyroxine concentration; CRC cis rs3785574 0.962 rs58131426 chr17:61854375 T/C cg22520471 chr17:61851767 DDX42;CCDC47 0.46 6.44 0.33 4.14e-10 Height; CRC cis rs4713118 0.615 rs57252182 chr6:27720249 C/A cg26587870 chr6:27730563 NA -0.36 -5.61 -0.3 4.28e-8 Parkinson's disease; CRC cis rs7945705 0.875 rs2568065 chr11:8889648 C/T cg14711859 chr11:8959438 ASCL3 0.44 7.28 0.37 2.42e-12 Hemoglobin concentration; CRC cis rs7216064 1.000 rs3206817 chr17:65892834 A/G cg12091567 chr17:66097778 LOC651250 -0.6 -6.95 -0.36 1.97e-11 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CRC cis rs1008375 1.000 rs2159583 chr4:17658838 T/C cg02297831 chr4:17616191 MED28 0.44 5.79 0.3 1.62e-8 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs79387448 0.745 rs79107058 chr2:103164257 C/A cg09003973 chr2:102972529 NA 0.73 8.01 0.4 1.97e-14 Gut microbiota (bacterial taxa); CRC cis rs11190604 1.000 rs2298075 chr10:102247408 C/A cg07080220 chr10:102295463 HIF1AN 0.49 5.91 0.31 8.45e-9 Palmitoleic acid (16:1n-7) levels; CRC cis rs6502050 0.835 rs4789732 chr17:80131382 A/G cg19223190 chr17:80058835 NA 0.38 6.02 0.32 4.64e-9 Life satisfaction; CRC cis rs8103278 0.507 rs2041975 chr19:46238555 T/C cg02376097 chr19:46275166 DMPK 0.4 6.24 0.33 1.37e-9 Coronary artery disease; CRC trans rs1005277 0.579 rs2474569 chr10:38383491 C/G cg27523141 chr10:43048294 ZNF37B 0.5 7.23 0.37 3.41e-12 Extrinsic epigenetic age acceleration; CRC cis rs7224685 0.569 rs8065660 chr17:4000858 A/G cg09695851 chr17:3907499 NA 0.5 6.36 0.33 6.84e-10 Type 2 diabetes; CRC cis rs7927771 0.864 rs3781625 chr11:47443080 T/C cg20307385 chr11:47447363 PSMC3 -0.62 -9.08 -0.45 1.01e-17 Subjective well-being; CRC cis rs3768617 0.811 rs10911200 chr1:182998377 T/C ch.1.3577855R chr1:183094577 LAMC1 0.6 8.83 0.44 6.46e-17 Fuchs's corneal dystrophy; CRC trans rs7618501 0.573 rs7634917 chr3:50049299 T/G cg21665057 chr3:196295764 WDR53;FBXO45 -0.62 -9.82 -0.48 3.98e-20 Intelligence (multi-trait analysis); CRC cis rs2075371 0.966 rs1646676 chr7:133999267 G/A cg20476274 chr7:133979776 SLC35B4 0.78 13.73 0.6 3.15e-34 Mean platelet volume; CRC cis rs394563 0.591 rs237028 chr6:149718650 C/T cg07828024 chr6:149772892 ZC3H12D -0.48 -9.03 -0.45 1.43e-17 Dupuytren's disease; CRC cis rs68170813 0.559 rs2107319 chr7:106863744 T/C cg23293999 chr7:106826042 HBP1 -0.48 -5.72 -0.3 2.36e-8 Coronary artery disease; CRC cis rs875971 1.000 rs2036264 chr7:65799904 G/A cg18876405 chr7:65276391 NA -0.52 -8.84 -0.44 6.02e-17 Aortic root size; CRC cis rs7666738 0.530 rs2865992 chr4:99067181 A/T cg05340658 chr4:99064831 C4orf37 0.49 7.5 0.38 5.92e-13 Colonoscopy-negative controls vs population controls; CRC cis rs9649213 0.593 rs55825602 chr7:98013039 T/C cg00277769 chr7:97922759 BAIAP2L1 -0.58 -9.89 -0.48 2.26e-20 Prostate cancer (SNP x SNP interaction); CRC cis rs1355223 0.525 rs7129533 chr11:34872292 T/C cg11058730 chr11:34937778 PDHX;APIP -0.43 -6.08 -0.32 3.26e-9 Systemic lupus erythematosus and Systemic sclerosis; CRC cis rs4076764 0.801 rs6675964 chr1:163375960 A/G cg06092702 chr1:163392909 NA -0.52 -8.18 -0.41 6.32e-15 Motion sickness; CRC cis rs1023500 0.551 rs133379 chr22:42468535 A/G cg15557168 chr22:42548783 NA -0.36 -5.92 -0.31 8.2e-9 Schizophrenia; CRC cis rs727479 0.543 rs1143704 chr15:51510702 T/A cg19946085 chr15:51559439 CYP19A1 -0.31 -6.3 -0.33 9.53e-10 Estradiol levels; CRC cis rs864537 0.618 rs2995089 chr1:167431193 G/A cg09179987 chr1:167433047 CD247 0.52 7.68 0.39 1.89e-13 Celiac disease or Rheumatoid arthritis;Celiac disease; CRC cis rs2274273 0.686 rs68083077 chr14:55574428 G/A cg10130446 chr14:55658398 DLGAP5 -0.44 -5.8 -0.3 1.55e-8 Protein biomarker; CRC trans rs2727020 0.729 rs7924782 chr11:49267249 A/G cg03929089 chr4:120376271 NA -0.81 -13.1 -0.59 7.6e-32 Coronary artery disease; CRC cis rs6951245 0.515 rs78461900 chr7:1007033 C/A cg26224354 chr7:1096374 C7orf50;GPR146 -0.83 -7.36 -0.38 1.44e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs4820294 0.669 rs732857 chr22:38060850 C/T cg21798802 chr22:38057573 PDXP 0.36 6.08 0.32 3.3e-9 Fat distribution (HIV); CRC cis rs4566357 0.615 rs10177528 chr2:227913706 G/A cg11843606 chr2:227700838 RHBDD1 -0.44 -6.84 -0.35 3.84e-11 Coronary artery disease; CRC cis rs634534 0.561 rs655744 chr11:65776585 G/T cg17985854 chr11:65770987 BANF1;EIF1AD -0.55 -9.22 -0.45 3.78e-18 Sum eosinophil basophil counts;Eosinophil counts; CRC cis rs765787 0.530 rs11636395 chr15:45535684 G/C cg24006582 chr15:45444508 DUOX1 -0.55 -8.58 -0.43 3.85e-16 Uric acid levels; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg02839273 chr15:85525387 PDE8A 0.43 6.25 0.33 1.27e-9 Intelligence (multi-trait analysis); CRC cis rs9611565 0.659 rs4822035 chr22:41935912 A/G cg03806693 chr22:41940476 POLR3H 1.11 14.57 0.63 1.81e-37 Vitiligo; CRC trans rs35110281 0.744 rs162398 chr21:44949285 T/C cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.42 6.77 0.35 5.78e-11 Mean corpuscular volume; CRC cis rs1005277 0.579 rs2505197 chr10:38393310 T/C cg17219203 chr10:38645113 HSD17B7P2 -0.41 -5.76 -0.3 1.9e-8 Extrinsic epigenetic age acceleration; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg09898070 chr2:48009866 MSH6 0.44 7.19 0.37 4.31e-12 Liver disease severity in Alagille syndrome; CRC cis rs9814567 0.686 rs1404289 chr3:134358109 C/G cg06109529 chr3:134205091 CEP63;ANAPC13 0.62 8.85 0.44 5.56e-17 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs78456975 0.739 rs11896906 chr2:1519550 A/G cg12573674 chr2:1569213 NA -0.63 -7.44 -0.38 9.13e-13 Placebo response in major depressive disorder (% change in symptom score); CRC cis rs727505 1.000 rs67585224 chr7:124537476 A/C cg23710748 chr7:124431027 NA -0.83 -14.62 -0.63 1.16e-37 Lewy body disease; CRC cis rs6740322 0.948 rs6722694 chr2:43569798 C/G cg06169590 chr2:43455088 ZFP36L2;LOC100129726 -0.59 -7.47 -0.38 7.2e-13 Coronary artery disease; CRC cis rs9906944 0.933 rs35051752 chr17:47089908 G/A cg09029085 chr17:47094198 IGF2BP1 0.3 5.65 0.3 3.53e-8 Intelligence (multi-trait analysis);Body fat percentage; CRC cis rs11122272 0.735 rs2437150 chr1:231488524 A/G cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX 0.54 8.35 0.42 1.89e-15 Hemoglobin concentration; CRC cis rs13118159 0.934 rs4974608 chr4:1356780 C/T cg02018176 chr4:1364513 KIAA1530 0.37 6.18 0.32 1.89e-9 Longevity; CRC cis rs4843747 0.671 rs4072871 chr16:88106614 C/T cg17633681 chr16:88106987 BANP 0.88 16.38 0.67 1.6e-44 Menopause (age at onset); CRC cis rs8072100 0.846 rs4264433 chr17:45737275 A/T cg08085267 chr17:45401833 C17orf57 0.66 10.92 0.52 6.78e-24 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs2019137 0.967 rs895412 chr2:113973964 T/C cg11763394 chr2:113992921 PAX8;LOC440839;LOC654433 -0.5 -7.18 -0.37 4.68e-12 Lymphocyte counts; CRC cis rs1707322 0.686 rs3014235 chr1:46091512 A/G cg03146154 chr1:46216737 IPP -0.66 -9.35 -0.46 1.44e-18 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs11976180 0.517 rs6949375 chr7:143773851 T/G cg16347377 chr7:143956670 OR2A7 -0.51 -5.93 -0.31 7.48e-9 Obesity-related traits; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg07775675 chr17:74379922 SPHK1 0.44 6.33 0.33 8.19e-10 Response to antipsychotic treatment; CRC cis rs9527 0.590 rs7912517 chr10:104905529 G/A cg15744005 chr10:104629667 AS3MT -0.3 -5.89 -0.31 9.3e-9 Arsenic metabolism; CRC cis rs7927771 0.560 rs4752858 chr11:47685829 C/T cg20307385 chr11:47447363 PSMC3 -0.48 -7.24 -0.37 3.13e-12 Subjective well-being; CRC cis rs6952808 0.823 rs10950448 chr7:1966492 G/C cg22963979 chr7:1858916 MAD1L1 -0.54 -7.68 -0.39 1.78e-13 Bipolar disorder and schizophrenia; CRC cis rs9325144 0.560 rs7304568 chr12:38632408 G/A cg26384229 chr12:38710491 ALG10B -0.49 -7.21 -0.37 3.91e-12 Morning vs. evening chronotype; CRC cis rs10504229 0.683 rs2101864 chr8:58113226 C/T cg05313129 chr8:58192883 C8orf71 -0.42 -5.85 -0.31 1.16e-8 Developmental language disorder (linguistic errors); CRC trans rs8002861 0.935 rs7318147 chr13:44445153 C/G cg17145862 chr1:211918768 LPGAT1 -0.61 -11.34 -0.53 2.15e-25 Leprosy; CRC cis rs4713118 0.621 rs9368548 chr6:28034737 A/G cg15786705 chr6:28176104 NA 0.72 9.34 0.46 1.52e-18 Parkinson's disease; CRC cis rs929596 0.606 rs10178992 chr2:234657877 T/A cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.63 -9.31 -0.46 1.83e-18 Total bilirubin levels in HIV-1 infection; CRC cis rs6964587 0.839 rs10808086 chr7:91447515 T/C cg17063962 chr7:91808500 NA 0.68 10.84 0.51 1.28e-23 Breast cancer; CRC cis rs9522267 0.535 rs7323631 chr13:112232269 A/G cg14352298 chr13:112236639 NA 0.3 6.71 0.35 8.5e-11 Hepatitis; CRC cis rs1448094 0.511 rs10746353 chr12:86150146 A/T cg19622623 chr12:86230825 RASSF9 0.4 6.15 0.32 2.22e-9 Major depressive disorder; CRC trans rs7395662 0.929 rs8186263 chr11:48737935 A/T cg21153622 chr11:89784906 NA -0.48 -7.77 -0.39 1.03e-13 HDL cholesterol; CRC cis rs13191362 0.938 rs35395472 chr6:163008493 G/A cg23758597 chr6:163146217 PARK2 -0.55 -6.12 -0.32 2.7e-9 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs4665809 0.877 rs34536218 chr2:26287376 T/A cg25036284 chr2:26402008 FAM59B 0.53 6.16 0.32 2.1e-9 Gut microbiome composition (summer); CRC cis rs3749237 0.595 rs2878298 chr3:49406080 T/C cg03060546 chr3:49711283 APEH 0.6 10.25 0.49 1.36e-21 Resting heart rate; CRC cis rs2842992 1.000 rs2842992 chr6:160071159 G/A cg16489826 chr6:160211363 TCP1;MRPL18 0.48 6.39 0.33 5.61e-10 Age-related macular degeneration (geographic atrophy); CRC cis rs9916302 0.904 rs7223331 chr17:37482930 A/G cg07936489 chr17:37558343 FBXL20 0.8 12.3 0.56 7.23e-29 Glomerular filtration rate (creatinine); CRC cis rs6519955 0.796 rs4072455 chr22:46422938 T/C cg05468064 chr22:46423449 NA 0.49 9.24 0.45 3.24e-18 Dupuytren's disease; CRC cis rs3823572 0.542 rs28654576 chr7:133624445 A/G cg03336402 chr7:133662267 EXOC4 0.67 10.27 0.49 1.25e-21 Intelligence (multi-trait analysis); CRC cis rs7618915 0.547 rs11130315 chr3:52697163 A/G cg18099408 chr3:52552593 STAB1 -0.44 -7.22 -0.37 3.66e-12 Bipolar disorder; CRC cis rs951366 0.789 rs823121 chr1:205724302 A/G cg23034840 chr1:205782522 SLC41A1 -0.47 -6.5 -0.34 2.97e-10 Menarche (age at onset); CRC cis rs2257205 0.667 rs16943200 chr17:56829611 A/G cg25885038 chr17:56607967 SEPT4 -0.53 -5.75 -0.3 2.07e-8 Pancreatic cancer; CRC cis rs4975616 0.804 rs459961 chr5:1337106 T/A cg26373071 chr5:1325741 CLPTM1L 0.55 10.13 0.49 3.47e-21 Lung cancer; CRC cis rs780096 0.526 rs1406295 chr2:27689700 A/G cg12000995 chr2:27665139 KRTCAP3 -0.32 -6.67 -0.35 1.1e-10 Total body bone mineral density; CRC trans rs6601327 0.540 rs6982148 chr8:9581070 G/C cg06636001 chr8:8085503 FLJ10661 -0.51 -7.44 -0.38 8.57e-13 Multiple myeloma (hyperdiploidy); CRC cis rs7932354 0.583 rs6485692 chr11:46804583 G/C cg19486271 chr11:47235900 DDB2 -0.43 -6.51 -0.34 2.78e-10 Bone mineral density (hip);Bone mineral density; CRC cis rs929596 0.785 rs6747843 chr2:234664354 G/A cg02227331 chr2:234663937 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 0.42 5.79 0.3 1.64e-8 Total bilirubin levels in HIV-1 infection; CRC cis rs611744 0.529 rs13282825 chr8:109263237 T/C cg21045802 chr8:109455806 TTC35 0.42 6.63 0.34 1.41e-10 Dupuytren's disease; CRC cis rs2197308 0.765 rs11182992 chr12:37935572 G/C cg26384229 chr12:38710491 ALG10B 0.68 8.97 0.44 2.37e-17 Morning vs. evening chronotype; CRC cis rs7680126 0.633 rs11729318 chr4:10336919 G/C cg11266682 chr4:10021025 SLC2A9 -0.39 -6.0 -0.31 5.27e-9 Urate levels in lean individuals;Urate levels in overweight individuals;Urate levels in obese individuals; CRC cis rs7412746 0.658 rs2864869 chr1:150734655 G/A cg10589385 chr1:150898437 SETDB1 0.31 6.34 0.33 7.79e-10 Melanoma; CRC cis rs7772486 0.790 rs7753092 chr6:146248863 C/T cg13319975 chr6:146136371 FBXO30 0.43 6.54 0.34 2.4e-10 Lobe attachment (rater-scored or self-reported); CRC cis rs4713118 0.666 rs2893930 chr6:27738806 T/C cg06470822 chr6:28175283 NA 0.84 9.56 0.47 2.85e-19 Parkinson's disease; CRC cis rs7731657 0.537 rs12332151 chr5:130344771 T/C cg08523029 chr5:130500466 HINT1 -0.45 -5.77 -0.3 1.85e-8 Fasting plasma glucose; CRC cis rs6724607 1.000 rs13410230 chr2:191446252 A/G cg10560079 chr2:191398806 TMEM194B 0.45 6.41 0.33 5.01e-10 Pulse pressure; CRC cis rs10979 1.000 rs34960207 chr6:143886398 C/T cg25407410 chr6:143891975 LOC285740 -0.81 -13.21 -0.59 2.85e-32 Hypospadias; CRC cis rs2404602 0.692 rs2120108 chr15:76869929 G/T cg22467129 chr15:76604101 ETFA 0.41 6.65 0.34 1.22e-10 Blood metabolite levels; CRC cis rs7586879 0.639 rs2033656 chr2:25100902 C/G cg04586622 chr2:25135609 ADCY3 -0.55 -10.18 -0.49 2.48e-21 Body mass index; CRC cis rs9303280 0.901 rs12936231 chr17:38029120 C/G cg00129232 chr17:37814104 STARD3 -0.44 -6.86 -0.35 3.37e-11 Self-reported allergy; CRC cis rs10870270 1.000 rs7898755 chr10:133777122 G/A cg08754478 chr10:133766260 PPP2R2D -0.66 -9.21 -0.45 3.96e-18 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; CRC cis rs2302190 0.769 rs7218778 chr17:56664248 T/G cg12560992 chr17:57184187 TRIM37 0.53 6.17 0.32 1.98e-9 Vitamin D levels; CRC cis rs1003719 0.742 rs8129231 chr21:38501034 A/G cg10648535 chr21:38446584 PIGP;TTC3 -0.48 -6.7 -0.35 8.99e-11 Eye color traits; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg11783451 chr7:23637068 CCDC126 0.48 6.83 0.35 4.05e-11 Response to antipsychotic treatment; CRC cis rs2576037 0.526 rs4258717 chr18:44456954 T/C cg07643061 chr18:44555308 TCEB3C;TCEB3CL;KATNAL2 -0.32 -5.64 -0.3 3.67e-8 Personality dimensions; CRC cis rs6570726 0.689 rs411785 chr6:145888398 G/A cg13319975 chr6:146136371 FBXO30 -0.43 -6.31 -0.33 9.09e-10 Lobe attachment (rater-scored or self-reported); CRC trans rs7824557 0.564 rs6601584 chr8:11232343 C/G cg06636001 chr8:8085503 FLJ10661 -0.49 -7.48 -0.38 6.75e-13 Retinal vascular caliber; CRC cis rs7786877 0.680 rs28584500 chr7:100216341 G/A cg20848291 chr7:100343083 ZAN -0.52 -6.41 -0.33 4.98e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC trans rs35110281 0.805 rs2838330 chr21:45023876 T/A cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.45 7.33 0.37 1.75e-12 Mean corpuscular volume; CRC cis rs57590327 0.508 rs13093082 chr3:81949958 C/T cg07356753 chr3:81810745 GBE1 -0.59 -8.01 -0.4 2e-14 Extraversion; CRC cis rs7833790 1.000 rs7833384 chr8:82730915 T/C cg17211192 chr8:82754475 SNX16 -0.54 -6.82 -0.35 4.25e-11 Diastolic blood pressure; CRC cis rs798554 0.731 rs2283779 chr7:2815140 G/A cg04166393 chr7:2884313 GNA12 0.4 5.82 0.31 1.38e-8 Height; CRC cis rs514406 0.929 rs557920 chr1:53338757 C/A cg08859206 chr1:53392774 SCP2 -0.47 -7.25 -0.37 2.92e-12 Monocyte count; CRC cis rs2276314 0.947 rs4799831 chr18:33554775 A/G cg05985134 chr18:33552581 C18orf21 0.45 6.18 0.32 1.87e-9 Endometriosis;Drug-induced torsades de pointes; CRC cis rs7618915 0.501 rs1468638 chr3:52748058 T/C cg15147215 chr3:52552868 STAB1 -0.63 -10.57 -0.5 1.14e-22 Bipolar disorder; CRC cis rs9487051 0.676 rs6928622 chr6:109595112 C/T cg01475377 chr6:109611718 NA -0.37 -6.58 -0.34 1.85e-10 Reticulocyte fraction of red cells; CRC trans rs1814175 0.791 rs1722011 chr11:49899340 G/C cg11707556 chr5:10655725 ANKRD33B -0.44 -8.31 -0.42 2.53e-15 Height; CRC cis rs2019137 0.936 rs12620738 chr2:113963739 C/T cg11763394 chr2:113992921 PAX8;LOC440839;LOC654433 -0.51 -7.23 -0.37 3.32e-12 Lymphocyte counts; CRC cis rs826838 1.000 rs11514441 chr12:38775190 C/T cg13010199 chr12:38710504 ALG10B 0.46 6.02 0.32 4.65e-9 Heart rate; CRC cis rs875971 0.660 rs10281080 chr7:66042441 T/C cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.43 -6.32 -0.33 8.44e-10 Aortic root size; CRC cis rs12701220 0.655 rs7784403 chr7:1153077 G/A cg00990874 chr7:1149470 C7orf50 -0.66 -8.61 -0.43 3.04e-16 Bronchopulmonary dysplasia; CRC cis rs3736485 0.966 rs7182977 chr15:51854130 C/G cg08986416 chr15:51914746 DMXL2 -0.45 -6.56 -0.34 2.12e-10 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs9660992 1.000 rs9660992 chr1:205249450 A/G cg21643547 chr1:205240462 TMCC2 -0.42 -7.06 -0.36 1e-11 Mean corpuscular volume;Mean platelet volume; CRC trans rs2211560 0.507 rs605320 chr1:61284339 A/G cg21640187 chr6:4282172 NA 0.3 5.98 0.31 5.8e-9 Facial morphology (factor 12, vertical position of sublabial sulcus relative to central midface); CRC cis rs6964587 1.000 rs55745934 chr7:91670998 T/C cg17063962 chr7:91808500 NA 0.76 12.3 0.56 7.53e-29 Breast cancer; CRC cis rs7827545 1.000 rs4909481 chr8:135564555 A/G cg17885191 chr8:135476712 NA 0.54 7.41 0.38 1.06e-12 Hypertension (SNP x SNP interaction); CRC cis rs1552244 0.688 rs7645137 chr3:10020549 A/AT cg16606324 chr3:10149918 C3orf24 0.63 8.19 0.41 5.81e-15 Alzheimer's disease; CRC cis rs754466 0.510 rs10824579 chr10:79590685 C/T cg26805224 chr10:79626177 DLG5 -0.45 -6.89 -0.36 2.84e-11 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs11098499 0.604 rs17051352 chr4:120581427 G/A cg24375607 chr4:120327624 NA 0.5 7.49 0.38 6.34e-13 Corneal astigmatism; CRC cis rs9325144 0.560 rs7971313 chr12:38653413 A/G cg26384229 chr12:38710491 ALG10B -0.49 -7.3 -0.37 2.2e-12 Morning vs. evening chronotype; CRC cis rs3741404 0.560 rs2875748 chr11:63915537 G/A cg15107132 chr11:63991130 FERMT3 0.45 7.51 0.38 5.7e-13 Platelet count; CRC cis rs4481887 0.927 rs4581306 chr1:248476158 C/A cg00666640 chr1:248458726 OR2T12 0.45 7.8 0.4 8.31e-14 Common traits (Other); CRC cis rs11864453 0.826 rs6499559 chr16:72132064 G/C cg23815491 chr16:72088622 HP 0.53 8.11 0.41 1.04e-14 Fibrinogen levels; CRC cis rs864537 0.646 rs2995091 chr1:167434277 T/C cg22356347 chr1:167427500 CD247 -0.4 -6.04 -0.32 4.19e-9 Celiac disease or Rheumatoid arthritis;Celiac disease; CRC cis rs6662572 0.686 rs113117837 chr1:46278158 G/A cg03123370 chr1:45965343 CCDC163P;MMACHC 0.47 6.0 0.31 5.08e-9 Blood protein levels; CRC cis rs7680126 0.633 rs4697743 chr4:10294833 A/G cg00071950 chr4:10020882 SLC2A9 -0.45 -5.87 -0.31 1.05e-8 Urate levels in lean individuals;Urate levels in overweight individuals;Urate levels in obese individuals; CRC cis rs6867032 0.958 rs9312970 chr5:2002415 C/A cg26168224 chr5:2018326 NA -0.85 -13.74 -0.6 2.97e-34 Gut microbiome composition (winter); CRC cis rs35110281 0.744 rs162395 chr21:44945759 T/C cg01579765 chr21:45077557 HSF2BP -0.37 -6.79 -0.35 5.12e-11 Mean corpuscular volume; CRC cis rs7615952 0.641 rs12487875 chr3:125787224 C/A cg15145296 chr3:125709740 NA -0.58 -6.91 -0.36 2.57e-11 Blood pressure (smoking interaction); CRC cis rs7605827 0.930 rs11692624 chr2:15499127 C/T cg19274914 chr2:15703543 NA 0.38 5.73 0.3 2.28e-8 Educational attainment (years of education); CRC trans rs11581859 0.950 rs72730327 chr1:99392984 C/T cg12183875 chr3:169587454 LRRC31 0.28 6.35 0.33 7.33e-10 Response to cognitive-behavioural therapy in anxiety disorder; CRC cis rs763121 0.853 rs35565791 chr22:39063011 C/A cg06544989 chr22:39130855 UNC84B 0.46 7.11 0.37 7.19e-12 Menopause (age at onset); CRC cis rs57221529 0.766 rs72703064 chr5:587825 T/C cg14541582 chr5:601475 NA -0.37 -7.17 -0.37 5.13e-12 Lung disease severity in cystic fibrosis; CRC cis rs6860806 0.661 rs334902 chr5:131586559 C/G cg09877947 chr5:131593287 PDLIM4 0.47 8.69 0.43 1.75e-16 Breast cancer; CRC cis rs12928939 0.723 rs28667298 chr16:71855134 T/G cg03805757 chr16:71968109 PKD1L3 -0.53 -7.07 -0.36 9.19e-12 Post bronchodilator FEV1; CRC cis rs7043114 0.525 rs4744136 chr9:95275024 A/G cg13798575 chr9:95087839 CENPP;NOL8 0.39 5.74 0.3 2.19e-8 Height; CRC cis rs1005277 0.579 rs2474595 chr10:38426782 C/G cg00409905 chr10:38381863 ZNF37A 0.67 10.97 0.52 4.5e-24 Extrinsic epigenetic age acceleration; CRC cis rs7043114 0.525 rs2025388 chr9:95128740 T/C cg13798575 chr9:95087839 CENPP;NOL8 -0.4 -5.98 -0.31 5.7e-9 Height; CRC cis rs4363385 0.667 rs73014331 chr1:152964533 A/G cg25856811 chr1:152973957 SPRR3 -0.27 -7.37 -0.38 1.35e-12 Inflammatory skin disease; CRC cis rs12900413 0.603 rs2351493 chr15:90299536 A/G cg24249390 chr15:90295951 MESP1 -0.57 -8.8 -0.44 8.08e-17 Coronary artery aneurysm in Kawasaki disease; CRC cis rs2243480 1.000 rs437889 chr7:65509234 G/A cg12463550 chr7:65579703 CRCP 0.75 6.81 0.35 4.7e-11 Diabetic kidney disease; CRC cis rs853679 0.517 rs36078605 chr6:28078032 A/C cg02683197 chr6:28174875 NA 0.85 10.37 0.5 5.51e-22 Depression; CRC cis rs7615952 0.576 rs6780025 chr3:125815624 A/C cg04553112 chr3:125709451 NA -0.54 -6.17 -0.32 1.97e-9 Blood pressure (smoking interaction); CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg00764560 chr22:42016991 XRCC6;PPPDE2 0.48 6.71 0.35 8.73e-11 Anxiety disorder; CRC cis rs4563143 0.663 rs5025682 chr19:29238670 A/C cg03161606 chr19:29218774 NA 0.61 7.97 0.4 2.63e-14 Methadone dose in opioid dependence; CRC cis rs1018836 0.663 rs12674903 chr8:91475774 T/C cg16814680 chr8:91681699 NA -0.65 -10.05 -0.48 6.77e-21 Ejection fraction in Tripanosoma cruzi seropositivity; CRC trans rs2055729 0.710 rs112406488 chr8:9736362 T/C cg08975724 chr8:8085496 FLJ10661 0.5 6.23 0.32 1.46e-9 Multiple myeloma (hyperdiploidy); CRC cis rs79387448 0.808 rs77518775 chr2:103237642 T/C cg00507830 chr2:103233733 NA 0.74 8.15 0.41 7.96e-15 Gut microbiota (bacterial taxa); CRC cis rs3818285 0.504 rs4917547 chr10:111652285 T/C cg00817464 chr10:111662876 XPNPEP1 -0.44 -5.93 -0.31 7.72e-9 Superior crus of antihelix expression; CRC cis rs734999 0.505 rs4445406 chr1:2539400 T/C cg20673091 chr1:2541236 MMEL1 0.37 6.01 0.31 4.94e-9 Ulcerative colitis; CRC cis rs1878931 0.520 rs2015640 chr16:3465018 G/C cg26668626 chr16:3451006 ZNF174;ZNF434 -0.58 -6.87 -0.35 3.14e-11 Body mass index (adult); CRC cis rs748404 0.723 rs573169 chr15:43550581 C/T cg02155558 chr15:43621948 ADAL;LCMT2 0.41 6.23 0.32 1.4e-9 Lung cancer; CRC cis rs9768139 0.611 rs12698211 chr7:158119623 G/A cg23298862 chr7:158159286 PTPRN2 0.38 5.98 0.31 5.8e-9 Calcium levels; CRC cis rs79349575 0.721 rs3744608 chr17:46993233 C/G cg22482690 chr17:47019901 SNF8 0.48 8.01 0.4 2.05e-14 Type 2 diabetes; CRC cis rs1395 0.778 rs34618115 chr2:27418289 G/A cg14242246 chr2:27434262 C2orf28;SLC5A6 0.4 7.38 0.38 1.32e-12 Blood metabolite levels; CRC cis rs7666738 0.822 rs13110418 chr4:99046963 G/A cg05340658 chr4:99064831 C4orf37 0.6 9.35 0.46 1.4e-18 Colonoscopy-negative controls vs population controls; CRC cis rs736801 0.740 rs12515180 chr5:131785684 C/T cg02033258 chr5:131593261 PDLIM4 0.32 5.66 0.3 3.31e-8 Breast cancer;Mosquito bite size; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg11129343 chr17:27717641 TAOK1 0.46 6.47 0.34 3.6e-10 Response to antipsychotic treatment; CRC cis rs8105895 0.935 rs4510150 chr19:22239669 A/G cg02657401 chr19:22469223 NA -0.34 -5.65 -0.3 3.56e-8 Body mass index (change over time); CRC cis rs7591163 1.000 rs4300818 chr2:228713255 G/T cg14329157 chr2:228736135 WDR69 -0.47 -6.53 -0.34 2.48e-10 Blood pressure; CRC cis rs2228479 0.867 rs57940434 chr16:89975496 G/A cg19635926 chr16:89946313 TCF25 0.53 5.72 0.3 2.42e-8 Skin colour saturation; CRC cis rs6938 0.597 rs11856413 chr15:75199892 A/G cg18612461 chr15:75251733 NA 0.38 5.82 0.31 1.38e-8 Breast cancer; CRC cis rs747650 0.699 rs4237547 chr11:47236405 C/G cg03339077 chr11:47165057 C11orf49 0.46 6.72 0.35 7.93e-11 Acne (severe); CRC cis rs7847628 0.551 rs10818476 chr9:123572038 A/G cg09419670 chr9:123605666 PSMD5;LOC253039 0.97 21.05 0.76 6.79e-63 Birth weight; CRC cis rs6502050 0.723 rs8077209 chr17:80163221 A/G cg02741985 chr17:80059408 CCDC57 0.44 7.28 0.37 2.55e-12 Life satisfaction; CRC cis rs7493 0.901 rs11764079 chr7:95026229 A/G cg21856205 chr7:94953877 PON1 0.44 6.55 0.34 2.2e-10 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs7659604 0.521 rs4833235 chr4:122695136 C/A cg19748678 chr4:122722346 EXOSC9 -0.44 -6.02 -0.31 4.71e-9 Type 2 diabetes; CRC cis rs597539 0.652 rs488363 chr11:68658298 C/G cg06112835 chr11:68658793 MRPL21 0.47 7.57 0.38 3.88e-13 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs9902453 1.000 rs9906340 chr17:28398977 A/G cg26525008 chr17:28256777 EFCAB5;SSH2 -0.58 -8.85 -0.44 5.38e-17 Coffee consumption (cups per day); CRC cis rs9325144 0.560 rs10785562 chr12:38637419 A/C cg26384229 chr12:38710491 ALG10B -0.56 -8.27 -0.41 3.32e-15 Morning vs. evening chronotype; CRC trans rs7937682 0.883 rs472465 chr11:111468962 C/T cg18187862 chr3:45730750 SACM1L 0.43 6.14 0.32 2.38e-9 Primary sclerosing cholangitis; CRC cis rs6089584 0.888 rs6061979 chr20:60617141 C/G cg23262073 chr20:60523788 NA -0.46 -7.24 -0.37 3.23e-12 Body mass index; CRC cis rs28386778 0.897 rs8077013 chr17:61850392 C/T cg06873352 chr17:61820015 STRADA 0.79 14.96 0.64 5.82e-39 Prudent dietary pattern; CRC cis rs77633900 0.614 rs1905694 chr15:76951772 T/C cg21673338 chr15:77095150 SCAPER -0.72 -6.98 -0.36 1.68e-11 Non-glioblastoma glioma;Glioma; CRC cis rs9443645 0.901 rs6937465 chr6:79570345 G/T cg11833968 chr6:79620685 NA -0.35 -6.15 -0.32 2.23e-9 Intelligence (multi-trait analysis); CRC cis rs10504229 1.000 rs73607874 chr8:58173433 G/C cg05313129 chr8:58192883 C8orf71 -0.47 -6.99 -0.36 1.49e-11 Developmental language disorder (linguistic errors); CRC cis rs2882667 0.931 rs11955952 chr5:138329119 A/G cg04439458 chr5:138467593 SIL1 -0.32 -5.89 -0.31 9.6e-9 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs735396 0.770 rs1169315 chr12:121443753 T/G cg02403541 chr12:121454288 C12orf43 0.48 7.18 0.37 4.78e-12 N-glycan levels; CRC cis rs910316 1.000 rs10140851 chr14:75512612 G/A cg11812906 chr14:75593930 NEK9 0.63 9.96 0.48 1.39e-20 Height; CRC cis rs853679 0.542 rs9380063 chr6:28137853 A/G cg23161317 chr6:28129485 ZNF389 0.53 6.43 0.33 4.52e-10 Depression; CRC cis rs853679 0.517 rs35227624 chr6:28132726 A/G cg12963246 chr6:28129442 ZNF389 0.49 5.7 0.3 2.71e-8 Depression; CRC cis rs1218582 0.774 rs12036859 chr1:154859940 A/C cg16680214 chr1:154839983 KCNN3 0.51 9.71 0.47 8.9e-20 Prostate cancer; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg07156182 chr3:122513738 DIRC2;HSPBAP1 0.45 6.9 0.36 2.65e-11 Liver disease severity in Alagille syndrome; CRC cis rs6496044 0.568 rs2344436 chr15:86074906 C/T cg17133734 chr15:86042851 AKAP13 0.4 6.49 0.34 3.21e-10 Interstitial lung disease; CRC cis rs7043114 0.525 rs7869742 chr9:95256174 A/G cg14631576 chr9:95140430 CENPP -0.31 -5.72 -0.3 2.44e-8 Height; CRC cis rs28386778 0.897 rs1062790 chr17:61896455 A/G cg07362569 chr17:61921086 SMARCD2 0.38 5.95 0.31 6.87e-9 Prudent dietary pattern; CRC cis rs769267 0.930 rs10422819 chr19:19643028 C/A cg03709012 chr19:19516395 GATAD2A 0.72 11.12 0.52 1.33e-24 Tonsillectomy; CRC cis rs1113500 0.933 rs10881500 chr1:108638895 C/T cg06207961 chr1:108661230 NA 0.39 5.8 0.3 1.55e-8 Growth-regulated protein alpha levels; CRC cis rs10504229 0.645 rs6995814 chr8:58114159 C/T cg21724239 chr8:58056113 NA 0.49 6.77 0.35 5.94e-11 Developmental language disorder (linguistic errors); CRC cis rs8016982 0.698 rs8021385 chr14:81704682 G/A cg01989461 chr14:81687754 GTF2A1 0.55 8.68 0.43 1.84e-16 Schizophrenia; CRC cis rs1891275 0.515 rs1592051 chr10:93542186 A/G cg07889827 chr10:93443413 NA 0.41 6.74 0.35 7.08e-11 Intelligence (multi-trait analysis); CRC cis rs7258465 1.000 rs10442 chr19:18545341 A/C cg06462663 chr19:18546047 ISYNA1 0.5 7.39 0.38 1.26e-12 Breast cancer; CRC trans rs34421088 0.560 rs2618434 chr8:11398865 A/G cg16141378 chr3:129829833 LOC729375 0.47 6.99 0.36 1.57e-11 Neuroticism; CRC cis rs7552404 1.000 rs7513559 chr1:76173744 A/G cg10523679 chr1:76189770 ACADM 0.82 11.24 0.53 4.86e-25 Blood metabolite levels;Acylcarnitine levels; CRC cis rs7618915 0.501 rs3733045 chr3:52643307 A/G cg15147215 chr3:52552868 STAB1 -0.63 -10.67 -0.51 5.2e-23 Bipolar disorder; CRC cis rs561341 1.000 rs8077092 chr17:30281992 T/C cg12193833 chr17:30244370 NA -0.63 -7.96 -0.4 2.79e-14 Hip circumference adjusted for BMI; CRC cis rs1577917 1.000 rs1415753 chr6:86753074 C/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.54 -6.64 -0.34 1.29e-10 Response to antipsychotic treatment; CRC cis rs10504229 0.639 rs72650811 chr8:58115661 G/A cg02725872 chr8:58115012 NA -0.64 -11.55 -0.54 3.85e-26 Developmental language disorder (linguistic errors); CRC cis rs875971 0.965 rs7794930 chr7:65778546 A/C cg12463550 chr7:65579703 CRCP -0.5 -7.12 -0.37 6.71e-12 Aortic root size; CRC cis rs9926296 0.624 rs1110331 chr16:89774396 A/G cg04287289 chr16:89883240 FANCA -0.39 -6.3 -0.33 9.57e-10 Vitiligo; CRC cis rs9649213 0.593 rs6975156 chr7:97925534 T/C cg00277769 chr7:97922759 BAIAP2L1 -0.61 -10.68 -0.51 4.72e-23 Prostate cancer (SNP x SNP interaction); CRC cis rs644799 0.965 rs602512 chr11:95561682 G/A cg25622487 chr11:95524042 FAM76B;CEP57 0.76 11.89 0.55 2.38e-27 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs7949030 0.626 rs11231145 chr11:62328854 G/A cg22862634 chr11:62369728 EML3;MTA2 0.58 10.31 0.49 8.7e-22 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; CRC trans rs2228479 0.557 rs11648881 chr16:89862434 T/C cg24644049 chr4:85504048 CDS1 0.82 6.87 0.35 3.16e-11 Skin colour saturation; CRC cis rs13191362 1.000 rs35723993 chr6:163008197 C/T cg06582575 chr6:163149167 PACRG;PARK2 0.75 10.24 0.49 1.58e-21 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs10751667 0.666 rs4074231 chr11:978219 G/C ch.11.42038R chr11:967971 AP2A2 0.58 9.98 0.48 1.16e-20 Alzheimer's disease (late onset); CRC cis rs41271951 0.512 rs114222784 chr1:151084781 C/T cg11822372 chr1:151115635 SEMA6C -0.71 -5.72 -0.3 2.34e-8 Blood protein levels; CRC cis rs4638749 0.677 rs12712017 chr2:108843556 C/T cg25838818 chr2:108905173 SULT1C2 -0.34 -5.72 -0.3 2.33e-8 Blood pressure; CRC cis rs9322193 0.923 rs12176034 chr6:150121693 C/T cg07701084 chr6:150067640 NUP43 0.56 7.54 0.38 4.61e-13 Lung cancer; CRC cis rs6089584 0.927 rs1886007 chr20:60581049 G/A cg13770153 chr20:60521292 NA -0.53 -8.78 -0.44 9e-17 Body mass index; CRC trans rs3733585 0.588 rs6449154 chr4:9956404 C/T cg26043149 chr18:55253948 FECH -0.5 -7.65 -0.39 2.23e-13 Cleft plate (environmental tobacco smoke interaction); CRC cis rs752092 0.894 rs8036083 chr15:101767822 T/G cg19997662 chr15:101784653 CHSY1 -0.53 -8.34 -0.42 2.04e-15 Corneal structure; CRC cis rs2072510 0.569 rs7306086 chr12:96390502 T/C cg15438951 chr12:96389694 HAL -0.49 -5.92 -0.31 7.95e-9 Metabolite levels (small molecules and protein measures); CRC cis rs3540 0.960 rs8030390 chr15:90943471 C/T cg22089800 chr15:90895588 ZNF774 0.5 7.69 0.39 1.74e-13 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; CRC cis rs9814567 0.896 rs4435682 chr3:134344182 C/T cg06109529 chr3:134205091 CEP63;ANAPC13 0.68 9.79 0.48 4.84e-20 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs10504073 0.647 rs1511359 chr8:50006448 T/A cg00325661 chr8:49890786 NA 0.53 9.48 0.46 5.15e-19 Blood metabolite ratios; CRC cis rs7762018 0.607 rs79897010 chr6:170042874 C/G cg19338460 chr6:170058176 WDR27 -1.25 -10.26 -0.49 1.27e-21 Thiazide-induced adverse metabolic effects in hypertensive patients; CRC trans rs12699921 0.632 rs2723545 chr7:17859691 C/A cg15753394 chr6:17282781 RBM24 -0.36 -6.01 -0.31 5.04e-9 Fibrinogen levels; CRC cis rs896854 0.654 rs10429443 chr8:95971164 A/G cg23172400 chr8:95962367 TP53INP1 -0.48 -8.19 -0.41 5.98e-15 Type 2 diabetes; CRC cis rs4363385 0.747 rs3737867 chr1:152976474 A/C cg25856811 chr1:152973957 SPRR3 -0.26 -7.14 -0.37 5.88e-12 Inflammatory skin disease; CRC cis rs10504229 1.000 rs67630725 chr8:58185580 G/A cg22535103 chr8:58192502 C8orf71 -0.82 -12.27 -0.56 9.63e-29 Developmental language disorder (linguistic errors); CRC cis rs6456156 0.846 rs9364891 chr6:167516319 C/T cg07741184 chr6:167504864 NA -0.34 -5.94 -0.31 7.32e-9 Primary biliary cholangitis; CRC cis rs10743315 0.778 rs9805106 chr12:19372357 A/G cg02471346 chr12:19282374 PLEKHA5 -0.63 -8.0 -0.4 2.18e-14 Gut microbiota (bacterial taxa); CRC cis rs1451375 0.617 rs10271341 chr7:50591583 A/C cg18232548 chr7:50535776 DDC 0.45 5.97 0.31 6.32e-9 Malaria; CRC cis rs601339 1.000 rs645491 chr12:123181661 T/C cg25190513 chr12:123201362 GPR109B -0.49 -6.21 -0.32 1.57e-9 Adiponectin levels; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg11283154 chr5:55008216 SLC38A9 0.38 6.18 0.32 1.89e-9 Liver disease severity in Alagille syndrome; CRC cis rs17270561 0.666 rs4712976 chr6:25842203 C/T cg17691542 chr6:26056736 HIST1H1C 0.69 9.19 0.45 4.71e-18 Iron status biomarkers; CRC cis rs951366 0.528 rs1172198 chr1:205662718 C/T cg11965913 chr1:205819406 PM20D1 0.75 11.11 0.52 1.49e-24 Menarche (age at onset); CRC cis rs8060686 0.920 rs73591976 chr16:67811590 C/A cg04539111 chr16:67997858 SLC12A4 -0.51 -5.91 -0.31 8.72e-9 HDL cholesterol;Metabolic syndrome; CRC cis rs727505 1.000 rs28523990 chr7:124436139 C/T cg23710748 chr7:124431027 NA -0.81 -13.95 -0.61 4.47e-35 Lewy body disease; CRC cis rs7586879 0.639 rs6713978 chr2:25120851 T/C cg04586622 chr2:25135609 ADCY3 -0.55 -10.2 -0.49 2.06e-21 Body mass index; CRC cis rs72634258 0.945 rs225120 chr1:8046378 C/T cg00042356 chr1:8021962 PARK7 0.63 7.23 0.37 3.39e-12 Inflammatory bowel disease; CRC trans rs2832077 0.527 rs2705690 chr21:30239245 T/A cg14791747 chr16:20752902 THUMPD1 -0.65 -10.19 -0.49 2.24e-21 Cognitive test performance; CRC cis rs78077440 0.866 rs78412068 chr5:40332809 T/G cg09067459 chr5:40385259 NA -0.54 -5.83 -0.31 1.3e-8 Multiple sclerosis; CRC cis rs5753618 0.561 rs5753521 chr22:31638027 T/C cg22777020 chr22:31556080 RNF185 -0.52 -6.04 -0.32 4.23e-9 Colorectal cancer; CRC cis rs7615952 0.599 rs6766327 chr3:125723677 C/G cg18479299 chr3:125709523 NA -0.55 -6.53 -0.34 2.54e-10 Blood pressure (smoking interaction); CRC cis rs2836974 0.568 rs4816620 chr21:40613786 A/G cg11644478 chr21:40555479 PSMG1 -0.71 -11.71 -0.54 1.06e-26 Cognitive function; CRC cis rs9649213 0.555 rs12667634 chr7:97965442 A/G cg21770322 chr7:97807741 LMTK2 0.52 8.47 0.42 8e-16 Prostate cancer (SNP x SNP interaction); CRC cis rs11031096 0.678 rs10767872 chr11:4184239 T/G cg18678763 chr11:4115507 RRM1 -0.35 -5.67 -0.3 3.05e-8 Mean corpuscular volume;Mean corpuscular hemoglobin; CRC cis rs875971 0.545 rs10950025 chr7:65623933 G/A cg18876405 chr7:65276391 NA 0.44 6.12 0.32 2.67e-9 Aortic root size; CRC cis rs35110281 0.693 rs2838345 chr21:45092715 C/T cg21573476 chr21:45109991 RRP1B -0.37 -5.78 -0.3 1.73e-8 Mean corpuscular volume; CRC cis rs5769707 0.839 rs73176988 chr22:49989649 G/T cg20744362 chr22:50050164 C22orf34 0.3 6.01 0.31 4.83e-9 Monocyte count;Monocyte percentage of white cells; CRC cis rs4862750 0.914 rs1863405 chr4:187874528 G/T cg03452623 chr4:187889614 NA 0.89 20.76 0.75 9.08e-62 Lobe attachment (rater-scored or self-reported); CRC cis rs6835098 0.961 rs28709762 chr4:174099149 T/C cg08422745 chr4:174089978 GALNT7 -0.95 -15.0 -0.64 4.17e-39 Dementia and core Alzheimer's disease neuropathologic changes; CRC cis rs13108904 0.875 rs1732099 chr4:1282696 T/C cg16405210 chr4:1374714 KIAA1530 0.44 6.5 0.34 2.91e-10 Obesity-related traits; CRC cis rs9611565 0.681 rs6002372 chr22:41801299 A/T cg06481639 chr22:41940642 POLR3H 0.52 5.82 0.31 1.4e-8 Vitiligo; CRC cis rs12024301 0.557 rs74720994 chr1:183607214 T/C cg11505048 chr1:183622726 RGL1;APOBEC4 0.77 6.73 0.35 7.45e-11 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs4927850 0.957 rs4927851 chr3:195751853 A/G cg00031303 chr3:195681400 NA 0.51 7.34 0.38 1.67e-12 Pancreatic cancer; CRC cis rs10540 0.908 rs1044707 chr11:491334 G/T cg08200582 chr11:442649 ANO9 0.7 7.4 0.38 1.16e-12 Body mass index; CRC cis rs2495707 0.624 rs2489006 chr10:102419893 G/A cg08729031 chr10:102416179 NA -0.41 -7.16 -0.37 5.21e-12 Body mass index; CRC cis rs10028773 0.506 rs12374346 chr4:120281705 G/A cg09307838 chr4:120376055 NA 0.68 10.53 0.5 1.51e-22 Educational attainment; CRC cis rs908922 0.676 rs4845441 chr1:152485421 C/T cg09873164 chr1:152488093 CRCT1 0.34 5.67 0.3 3.17e-8 Hair morphology; CRC cis rs34375054 0.525 rs7133864 chr12:125606180 C/T cg06987292 chr12:125626746 AACS -0.36 -6.23 -0.33 1.4e-9 Post bronchodilator FEV1/FVC ratio; CRC cis rs11711311 1.000 rs7622515 chr3:113472538 G/A cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.5 -6.89 -0.36 2.88e-11 IgG glycosylation; CRC cis rs7542091 0.635 rs985431 chr1:210043948 A/T cg22029157 chr1:209979665 IRF6 0.47 7.4 0.38 1.11e-12 Monobrow; CRC cis rs736408 0.660 rs2019065 chr3:52809525 C/T cg08222913 chr3:52553049 STAB1 0.36 6.82 0.35 4.36e-11 Bipolar disorder; CRC cis rs2976388 0.556 rs4736300 chr8:143829269 C/T cg24046110 chr8:143859143 LYNX1 -0.43 -6.67 -0.35 1.06e-10 Urinary tract infection frequency; CRC cis rs7223966 1.000 rs2874121 chr17:61731024 C/T cg05941027 chr17:61774174 LIMD2 0.36 6.57 0.34 2e-10 Hip circumference adjusted for BMI;Body mass index; CRC cis rs6582630 0.555 rs11182193 chr12:38474090 C/G cg13010199 chr12:38710504 ALG10B 0.49 6.58 0.34 1.87e-10 Drug-induced liver injury (flucloxacillin); CRC cis rs6061231 0.837 rs6121558 chr20:60961365 A/G cg24112000 chr20:60950667 NA -0.56 -8.52 -0.43 5.7e-16 Colorectal cancer; CRC cis rs875971 0.545 rs1796226 chr7:66087710 C/T cg03233332 chr7:66118400 NA -0.45 -6.3 -0.33 9.52e-10 Aortic root size; CRC cis rs17270561 0.723 rs12192635 chr6:25880907 A/T cg17691542 chr6:26056736 HIST1H1C 0.77 10.11 0.49 4.05e-21 Iron status biomarkers; CRC cis rs274567 0.599 rs11242110 chr5:131743777 A/C cg07395648 chr5:131743802 NA 0.57 9.23 0.45 3.48e-18 Blood metabolite levels; CRC cis rs2304069 0.601 rs216143 chr5:149444147 A/G cg22760475 chr5:149380129 HMGXB3;TIGD6 0.6 6.72 0.35 7.84e-11 HIV-1 control; CRC cis rs9527 0.614 rs2153774 chr10:104881035 T/C cg04362960 chr10:104952993 NT5C2 0.6 8.31 0.42 2.6e-15 Arsenic metabolism; CRC cis rs7811142 1.000 rs74460138 chr7:100027339 C/G cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.15 17.3 0.69 3.94e-48 Platelet count; CRC trans rs116095464 0.558 rs61689490 chr5:224904 T/C cg00938859 chr5:1591904 SDHAP3 0.7 7.63 0.39 2.58e-13 Breast cancer; CRC cis rs3823572 0.564 rs2953619 chr7:133669649 C/G cg03336402 chr7:133662267 EXOC4 -0.69 -10.56 -0.5 1.19e-22 Intelligence (multi-trait analysis); CRC cis rs7843479 0.965 rs878872 chr8:21834567 A/G cg17168535 chr8:21777572 XPO7 0.57 9.3 0.46 1.99e-18 Mean corpuscular volume; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg02914497 chr6:37787052 ZFAND3 0.48 6.34 0.33 7.66e-10 Anxiety disorder; CRC cis rs11212617 0.934 rs609557 chr11:108084513 G/T cg01991180 chr11:108092276 ATM;NPAT 0.41 6.27 0.33 1.11e-9 Response to metformin in type 2 diabetes (glycemic); CRC trans rs11874381 1.000 rs35337492 chr18:47210824 G/A cg03239335 chr2:3418641 TTC15 -0.41 -5.97 -0.31 6.24e-9 C-reactive protein levels or HDL-cholesterol levels (pleiotropy); CRC cis rs9513593 1.000 rs7325957 chr13:99965155 C/T cg21788972 chr13:99853209 UBAC2 -0.42 -5.61 -0.3 4.38e-8 Psoriasis; CRC cis rs11190604 1.000 rs74650218 chr10:102293830 C/T cg16342193 chr10:102329863 NA -0.36 -5.94 -0.31 7.21e-9 Palmitoleic acid (16:1n-7) levels; CRC cis rs7659604 0.521 rs13130789 chr4:122690166 G/A cg19748678 chr4:122722346 EXOSC9 -0.43 -5.95 -0.31 7e-9 Type 2 diabetes; CRC cis rs977987 0.806 rs35552529 chr16:75405879 G/C cg03315344 chr16:75512273 CHST6 0.53 8.85 0.44 5.63e-17 Dupuytren's disease; CRC cis rs898097 0.578 rs8069697 chr17:80908110 T/C cg03160526 chr17:80928410 B3GNTL1 0.5 8.3 0.42 2.64e-15 Breast cancer; CRC cis rs4665809 0.878 rs4143538 chr2:26290178 A/C cg04944784 chr2:26401820 FAM59B -0.65 -8.03 -0.4 1.74e-14 Gut microbiome composition (summer); CRC cis rs10504229 0.683 rs56408763 chr8:58137276 G/A cg21724239 chr8:58056113 NA 0.49 6.81 0.35 4.75e-11 Developmental language disorder (linguistic errors); CRC cis rs3858526 0.883 rs10769333 chr11:5939685 A/T cg05234568 chr11:5960015 NA -0.54 -7.38 -0.38 1.3e-12 DNA methylation (variation); CRC cis rs7618915 0.547 rs62255371 chr3:52747321 A/G cg10802521 chr3:52805072 NEK4 -0.59 -8.98 -0.44 2.07e-17 Bipolar disorder; CRC cis rs7666738 0.830 rs1896154 chr4:99021161 T/C cg05340658 chr4:99064831 C4orf37 0.61 9.51 0.46 4.05e-19 Colonoscopy-negative controls vs population controls; CRC cis rs1997103 1.000 rs6593238 chr7:55411048 A/G cg17469321 chr7:55412551 NA 0.72 11.28 0.53 3.48e-25 QRS interval (sulfonylurea treatment interaction); CRC cis rs524281 0.731 rs3814744 chr11:65809763 C/T cg16950941 chr11:66035639 RAB1B -0.52 -5.77 -0.3 1.81e-8 Electroencephalogram traits; CRC cis rs9902453 0.868 rs8066602 chr17:28523085 T/C cg26525008 chr17:28256777 EFCAB5;SSH2 0.67 10.84 0.51 1.24e-23 Coffee consumption (cups per day); CRC cis rs796364 1.000 rs281762 chr2:200799201 C/G cg23649088 chr2:200775458 C2orf69 0.55 5.95 0.31 6.71e-9 Schizophrenia; CRC cis rs11098499 0.954 rs17046116 chr4:120387259 G/A cg24375607 chr4:120327624 NA 0.5 7.72 0.39 1.4e-13 Corneal astigmatism; CRC cis rs7914558 0.966 rs10748836 chr10:104693917 G/A cg15744005 chr10:104629667 AS3MT -0.35 -7.54 -0.38 4.73e-13 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg22146484 chr8:57123862 CHCHD7;PLAG1 0.46 6.1 0.32 3.03e-9 Thyroid stimulating hormone; CRC cis rs7605827 0.930 rs7605077 chr2:15546240 C/A cg19274914 chr2:15703543 NA 0.4 5.94 0.31 7.2e-9 Educational attainment (years of education); CRC cis rs72781680 0.898 rs10490752 chr2:24025132 C/T cg08917208 chr2:24149416 ATAD2B 0.86 8.58 0.43 3.88e-16 Lymphocyte counts; CRC cis rs7208859 0.573 rs73267829 chr17:29003939 G/A cg01831904 chr17:28903510 LRRC37B2 -0.62 -6.23 -0.32 1.45e-9 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC trans rs2303319 0.504 rs56009150 chr2:162598582 T/C cg22677401 chr17:46026860 NA -0.68 -6.15 -0.32 2.24e-9 Cognitive function; CRC cis rs10504229 0.775 rs17805026 chr8:58160637 A/C cg02290350 chr8:58132656 NA -0.51 -6.39 -0.33 5.68e-10 Developmental language disorder (linguistic errors); CRC cis rs13191362 0.872 rs35443919 chr6:163055804 C/T cg14584255 chr6:163149320 PACRG;PARK2 0.43 6.06 0.32 3.82e-9 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC trans rs3780486 0.505 rs10217267 chr9:33146528 T/C cg04842962 chr6:43655489 MRPS18A 0.91 15.44 0.65 7.91e-41 IgG glycosylation; CRC cis rs875971 0.545 rs10950025 chr7:65623933 G/A cg11764359 chr7:65958608 NA 0.47 5.9 0.31 9.21e-9 Aortic root size; CRC cis rs7584330 0.554 rs62186170 chr2:238425883 C/T cg08992911 chr2:238395768 MLPH 0.47 5.76 0.3 1.89e-8 Prostate cancer; CRC cis rs6484504 0.652 rs485265 chr11:31407788 G/A cg14844989 chr11:31128820 NA 0.33 5.86 0.31 1.14e-8 Red blood cell count; CRC cis rs1499614 1.000 rs2659903 chr7:66180931 G/A cg18252515 chr7:66147081 NA -1.24 -14.58 -0.63 1.79e-37 Gout; CRC cis rs1448094 0.533 rs10863078 chr12:86152672 C/T cg18827107 chr12:86230957 RASSF9 0.39 5.98 0.31 5.76e-9 Major depressive disorder; CRC cis rs7208859 0.573 rs7223803 chr17:29077193 A/G cg01831904 chr17:28903510 LRRC37B2 -0.62 -6.41 -0.33 5.05e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC trans rs2727020 0.556 rs2866365 chr11:49390731 A/G cg11707556 chr5:10655725 ANKRD33B -0.47 -7.37 -0.38 1.41e-12 Coronary artery disease; CRC cis rs10504229 1.000 rs6989060 chr8:58178989 T/G cg02725872 chr8:58115012 NA -0.38 -6.43 -0.33 4.44e-10 Developmental language disorder (linguistic errors); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg03490839 chr16:73082051 ZFHX3 0.4 6.29 0.33 1.02e-9 Liver disease severity in Alagille syndrome; CRC cis rs4332037 0.713 rs56093134 chr7:1973970 C/T cg02421172 chr7:1938701 MAD1L1 0.48 6.46 0.34 3.82e-10 Bipolar disorder; CRC cis rs4285028 0.948 rs34158925 chr3:121678465 C/A cg20356878 chr3:121714668 ILDR1 -0.48 -6.95 -0.36 1.93e-11 Multiple sclerosis; CRC cis rs7666738 0.830 rs6532715 chr4:99016792 G/A cg05340658 chr4:99064831 C4orf37 0.61 9.48 0.46 5.18e-19 Colonoscopy-negative controls vs population controls; CRC cis rs2294693 0.891 rs9381024 chr6:40984262 A/C cg14769373 chr6:40998127 UNC5CL 0.47 5.87 0.31 1.07e-8 Gastric cancer;Non-cardia gastric cancer; CRC cis rs55871839 0.708 rs13261666 chr8:59814666 G/T cg07426533 chr8:59803705 TOX -0.34 -5.94 -0.31 7.16e-9 Pneumonia; CRC cis rs2857891 0.697 rs1004754 chr11:6946248 T/C cg02416716 chr11:6948024 ZNF215 0.58 5.93 0.31 7.58e-9 Response to cytadine analogues (cytosine arabinoside); CRC cis rs7103648 0.669 rs11039332 chr11:47695840 G/A cg20307385 chr11:47447363 PSMC3 0.77 10.83 0.51 1.37e-23 Diastolic blood pressure;Systolic blood pressure; CRC cis rs7914558 0.966 rs2065977 chr10:104729415 C/T cg04362960 chr10:104952993 NT5C2 0.62 9.39 0.46 1.02e-18 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs7224610 0.932 rs10852974 chr17:53372566 G/C cg02383154 chr17:53343283 HLF -0.34 -5.62 -0.3 4.04e-8 Urate levels; CRC cis rs7809950 0.817 rs34325395 chr7:107113808 C/G cg23024343 chr7:107201750 COG5 -0.75 -10.04 -0.48 7.14e-21 Coronary artery disease; CRC cis rs78456975 0.628 rs13426896 chr2:1554768 C/T cg01028140 chr2:1542097 TPO -0.58 -6.2 -0.32 1.65e-9 Placebo response in major depressive disorder (% change in symptom score); CRC cis rs909002 1.000 rs909002 chr1:32139635 C/T cg13919466 chr1:32135498 COL16A1 -0.4 -7.77 -0.39 1.03e-13 Intelligence (multi-trait analysis); CRC cis rs9611565 0.512 rs2899347 chr22:42158204 T/C cg06481639 chr22:41940642 POLR3H 0.52 5.6 0.3 4.46e-8 Vitiligo; CRC cis rs6838801 1.000 rs7694630 chr4:77556983 C/T cg17476223 chr4:77663285 SHROOM3 0.42 5.74 0.3 2.19e-8 Cleft lip with or without cleft palate; CRC cis rs6860806 0.507 rs270601 chr5:131656997 T/C cg22638593 chr5:131593259 PDLIM4 0.39 6.36 0.33 6.76e-10 Breast cancer; CRC cis rs728616 0.867 rs61859763 chr10:81671615 A/T cg11900509 chr10:81946545 ANXA11 -0.64 -6.52 -0.34 2.63e-10 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs10504229 0.639 rs55687236 chr8:58105856 C/T cg21724239 chr8:58056113 NA 0.81 9.85 0.48 3.21e-20 Developmental language disorder (linguistic errors); CRC cis rs853679 0.517 rs9368550 chr6:28051803 T/A cg02683197 chr6:28174875 NA 0.81 9.98 0.48 1.15e-20 Depression; CRC cis rs9443645 0.527 rs7756996 chr6:79509367 A/C cg05283184 chr6:79620031 NA -0.44 -6.41 -0.33 5e-10 Intelligence (multi-trait analysis); CRC cis rs4713118 0.616 rs9348789 chr6:28025486 C/T cg12172441 chr6:28176163 NA 0.55 6.96 0.36 1.83e-11 Parkinson's disease; CRC cis rs1862618 0.671 rs28397234 chr5:56248428 T/G cg18230493 chr5:56204884 C5orf35 0.59 8.82 0.44 7.05e-17 Initial pursuit acceleration; CRC cis rs10979 0.928 rs9496676 chr6:143895610 A/G cg25407410 chr6:143891975 LOC285740 -0.83 -13.64 -0.6 7.14e-34 Hypospadias; CRC cis rs738322 0.935 rs75387 chr22:38572057 C/T cg25457927 chr22:38595422 NA -0.36 -7.55 -0.38 4.45e-13 Cutaneous nevi; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg13789711 chr9:139743225 PHPT1 0.44 6.15 0.32 2.19e-9 Response to antipsychotic treatment; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg05966498 chr5:10761293 DAP -0.45 -6.71 -0.35 8.57e-11 Myopia (pathological); CRC cis rs7364180 0.582 rs139568 chr22:42210985 C/T cg03806693 chr22:41940476 POLR3H 0.55 8.01 0.4 1.98e-14 Alzheimer's disease biomarkers; CRC trans rs6561151 0.957 rs7995004 chr13:44478820 C/T cg12856521 chr11:46389249 DGKZ 0.63 9.38 0.46 1.1e-18 Crohn's disease; CRC cis rs1046896 0.561 rs8076476 chr17:80861017 A/C cg03160526 chr17:80928410 B3GNTL1 0.57 7.68 0.39 1.79e-13 Glycated hemoglobin levels; CRC cis rs736408 0.500 rs2878762 chr3:52919002 T/C cg11645453 chr3:52864694 ITIH4 0.46 8.06 0.41 1.44e-14 Bipolar disorder; CRC cis rs2404602 1.000 rs2404741 chr15:76851735 C/T cg22467129 chr15:76604101 ETFA -0.44 -7.51 -0.38 5.61e-13 Blood metabolite levels; CRC cis rs6604026 0.630 rs56193705 chr1:93455887 C/G cg17283838 chr1:93427260 FAM69A 0.46 5.97 0.31 6.21e-9 Multiple sclerosis; CRC cis rs7584330 0.657 rs7599658 chr2:238352898 A/C cg11271282 chr2:238384023 NA -0.46 -5.79 -0.3 1.63e-8 Prostate cancer; CRC cis rs910316 1.000 rs12889309 chr14:75593902 C/T cg11812906 chr14:75593930 NEK9 0.64 10.21 0.49 1.95e-21 Height; CRC cis rs6541297 1.000 rs7543050 chr1:230278291 C/G cg05784532 chr1:230284198 GALNT2 0.45 6.21 0.32 1.57e-9 Coronary artery disease; CRC cis rs7899719 1.000 rs10458641 chr10:77406954 C/T cg24369728 chr10:77472158 NA 0.4 6.65 0.34 1.2e-10 Exploratory eye movement dysfunction in schizophrenia (total eye scanning length); CRC cis rs7113874 0.531 rs7934396 chr11:8615632 C/G cg20771178 chr11:8615675 STK33 0.35 5.79 0.3 1.67e-8 Body mass index in physically active individuals;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs9399135 0.967 rs7773126 chr6:135318390 A/G cg24558204 chr6:135376177 HBS1L 0.49 7.55 0.38 4.23e-13 Red blood cell count; CRC trans rs2303319 0.504 rs62188988 chr2:162531068 T/C cg05722611 chr22:51001334 C22orf41 -0.65 -6.01 -0.31 4.97e-9 Cognitive function; CRC cis rs4253772 0.513 rs9615345 chr22:46713631 C/T cg09491104 chr22:46646882 C22orf40 -0.42 -6.21 -0.32 1.62e-9 LDL cholesterol;Cholesterol, total; CRC cis rs4819052 0.851 rs34101026 chr21:46662200 C/T cg02159808 chr21:46707872 POFUT2;LOC642852 0.49 6.42 0.33 4.89e-10 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs7914558 0.966 rs12766205 chr10:104893568 A/G cg15744005 chr10:104629667 AS3MT -0.34 -7.27 -0.37 2.57e-12 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs644799 0.562 rs1254989 chr11:95508121 A/G cg03916912 chr11:95522834 CEP57;FAM76B 0.74 12.04 0.55 6.53e-28 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs2658782 0.654 rs2248531 chr11:93255363 G/T cg15737290 chr11:93063684 CCDC67 0.51 7.74 0.39 1.24e-13 Pulmonary function decline; CRC cis rs4689592 0.587 rs3822269 chr4:7069901 T/C cg26116260 chr4:7069785 GRPEL1 1.0 15.15 0.64 1.09e-39 Monocyte percentage of white cells; CRC cis rs875971 0.862 rs1083554 chr7:65852341 T/C cg18876405 chr7:65276391 NA 0.54 8.69 0.43 1.77e-16 Aortic root size; CRC cis rs2932538 0.885 rs3762335 chr1:113100548 C/T cg22162597 chr1:113214053 CAPZA1 0.7 10.13 0.49 3.68e-21 Systolic blood pressure;Diastolic blood pressure;Hypertension;Blood pressure; CRC cis rs1448094 0.534 rs974818 chr12:86144307 T/C cg06740227 chr12:86229804 RASSF9 -0.37 -5.65 -0.3 3.47e-8 Major depressive disorder; CRC cis rs6500395 1.000 rs1872655 chr16:48670883 A/C cg04672837 chr16:48644449 N4BP1 0.45 6.73 0.35 7.64e-11 Response to tocilizumab in rheumatoid arthritis; CRC cis rs7107174 1.000 rs11237469 chr11:78072875 A/T cg02023728 chr11:77925099 USP35 0.48 7.29 0.37 2.35e-12 Testicular germ cell tumor; CRC cis rs4919694 0.901 rs10509763 chr10:104776391 G/A cg04362960 chr10:104952993 NT5C2 1.17 10.93 0.52 6.24e-24 Arsenic metabolism; CRC cis rs524023 1.000 rs505802 chr11:64357072 T/C cg14139581 chr11:64358342 SLC22A12 0.38 6.08 0.32 3.35e-9 Urate levels in obese individuals; CRC cis rs10883723 0.773 rs715439 chr10:104257809 A/C cg04362960 chr10:104952993 NT5C2 -0.43 -6.11 -0.32 2.8e-9 Allergic disease (asthma, hay fever or eczema); CRC cis rs6089584 0.606 rs2296082 chr20:60573983 A/G cg23463467 chr20:60627584 TAF4 0.39 7.87 0.4 5.19e-14 Body mass index; CRC cis rs2011503 1.000 rs2060275 chr19:19536208 G/C cg11584989 chr19:19387371 SF4 0.55 6.2 0.32 1.69e-9 Bipolar disorder; CRC cis rs3858526 0.959 rs10838795 chr11:5920721 A/G cg13902645 chr11:5959945 NA 0.6 8.47 0.42 8.01e-16 DNA methylation (variation); CRC cis rs10504229 0.683 rs77548248 chr8:58117542 G/A cg21724239 chr8:58056113 NA 0.52 7.13 0.37 6.58e-12 Developmental language disorder (linguistic errors); CRC cis rs4604732 0.685 rs4925673 chr1:247636800 T/C cg02104434 chr1:247694406 LOC148824;OR2C3 0.41 6.77 0.35 5.75e-11 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CRC cis rs6496667 0.779 rs8033897 chr15:90947842 T/G cg04176472 chr15:90893244 GABARAPL3 0.61 7.96 0.4 2.9e-14 Rheumatoid arthritis; CRC cis rs11098499 0.644 rs3986377 chr4:120260270 G/A cg09307838 chr4:120376055 NA 0.6 9.53 0.47 3.52e-19 Corneal astigmatism; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg23377693 chr6:43597122 MAD2L1BP;GTPBP2 0.5 6.42 0.33 4.71e-10 Thyroid stimulating hormone; CRC cis rs929354 0.742 rs7785227 chr7:156999297 C/T cg05182265 chr7:156933206 UBE3C -0.76 -14.52 -0.62 3.01e-37 Body mass index; CRC cis rs6694672 0.867 rs2786114 chr1:197302717 T/C cg13682187 chr1:196946512 CFHR5 0.45 5.96 0.31 6.61e-9 Asthma; CRC cis rs634534 0.622 rs531612 chr11:65705432 C/T cg26695010 chr11:65641043 EFEMP2 0.38 5.68 0.3 2.99e-8 Sum eosinophil basophil counts;Eosinophil counts; CRC cis rs12422267 0.536 rs11831679 chr12:132609960 C/T cg09764611 chr12:132620959 NA -0.59 -8.26 -0.41 3.7e-15 Plasma amyloid beta peptide concentrations (ABx-40); CRC cis rs6860806 0.531 rs272887 chr5:131665713 A/G cg12564285 chr5:131593104 PDLIM4 0.44 7.32 0.37 1.92e-12 Breast cancer; CRC cis rs3617 0.539 rs4687689 chr3:52948674 A/C cg15147215 chr3:52552868 STAB1 0.5 8.75 0.43 1.14e-16 Red blood cell count;Autism spectrum disorder or schizophrenia; CRC cis rs13108904 0.967 rs900029 chr4:1279145 C/T cg00684032 chr4:1343700 KIAA1530 0.48 6.99 0.36 1.58e-11 Obesity-related traits; CRC cis rs4713118 0.512 rs2622319 chr6:28120401 G/C cg12172441 chr6:28176163 NA 0.54 7.32 0.37 1.87e-12 Parkinson's disease; CRC cis rs9325144 0.555 rs6582576 chr12:38701230 C/T cg26384229 chr12:38710491 ALG10B -0.52 -7.85 -0.4 5.95e-14 Morning vs. evening chronotype; CRC trans rs11227306 0.934 rs11227313 chr11:65588938 C/T cg17712092 chr4:129076599 LARP1B 0.51 6.77 0.35 5.8200000000000003e-11 DNA methylation (variation); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg16782848 chr15:83479213 WHAMM 0.41 7.09 0.36 8.34e-12 Liver disease severity in Alagille syndrome; CRC cis rs9311676 0.632 rs11705721 chr3:58400414 T/C cg06643156 chr3:58380774 PXK 0.42 6.38 0.33 5.84e-10 Systemic lupus erythematosus; CRC cis rs34779708 0.931 rs11010101 chr10:35411045 T/A cg03585969 chr10:35415529 CREM 0.59 7.89 0.4 4.67e-14 Inflammatory bowel disease;Crohn's disease; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg18440893 chr6:16760537 ATXN1 -0.4 -6.13 -0.32 2.47e-9 Myopia (pathological); CRC cis rs870825 0.616 rs28666955 chr4:185631338 A/G cg04058563 chr4:185651563 MLF1IP 0.72 9.2 0.45 4.18e-18 Blood protein levels; CRC trans rs10838798 0.523 rs4752907 chr11:48170581 G/A cg15704280 chr7:45808275 SEPT13 -0.49 -6.84 -0.35 3.84e-11 Height; CRC cis rs611744 0.647 rs631775 chr8:109252746 T/C cg21045802 chr8:109455806 TTC35 0.4 6.29 0.33 1.04e-9 Dupuytren's disease; CRC cis rs10979 0.597 rs9321927 chr6:143913295 A/G cg25407410 chr6:143891975 LOC285740 0.66 8.67 0.43 2.01e-16 Hypospadias; CRC cis rs951366 0.789 rs823130 chr1:205714372 C/T cg17178900 chr1:205818956 PM20D1 0.68 9.86 0.48 2.89e-20 Menarche (age at onset); CRC cis rs929354 0.772 rs6969244 chr7:157004012 A/G cg05182265 chr7:156933206 UBE3C -0.76 -14.45 -0.62 5.56e-37 Body mass index; CRC cis rs7827545 1.000 rs6992097 chr8:135565844 G/A cg07299736 chr8:135490787 ZFAT -0.37 -6.2 -0.32 1.73e-9 Hypertension (SNP x SNP interaction); CRC cis rs7617773 1.000 rs6771889 chr3:48194326 C/T cg11946769 chr3:48343235 NME6 -0.51 -6.85 -0.35 3.73e-11 Coronary artery disease; CRC cis rs910316 1.000 rs11623413 chr14:75588824 C/T cg11812906 chr14:75593930 NEK9 -0.64 -10.23 -0.49 1.7e-21 Height; CRC cis rs4862750 0.758 rs2375915 chr4:187896255 A/C cg07414643 chr4:187882934 NA 0.37 6.44 0.33 4.15e-10 Lobe attachment (rater-scored or self-reported); CRC cis rs12541335 0.639 rs11135995 chr8:22200148 C/T cg02463440 chr8:22132932 PIWIL2 -0.48 -8.26 -0.41 3.66e-15 Hypertriglyceridemia; CRC cis rs12451471 0.529 rs2278620 chr17:78083565 G/A cg20811857 chr17:78079795 GAA -0.46 -6.69 -0.35 9.75e-11 Plateletcrit;Mean corpuscular hemoglobin concentration; CRC cis rs7552404 0.731 rs10873788 chr1:76367857 A/C cg22875332 chr1:76189707 ACADM 0.6 7.59 0.39 3.33e-13 Blood metabolite levels;Acylcarnitine levels; CRC cis rs919433 0.648 rs6434933 chr2:198426960 G/A cg10820045 chr2:198174542 NA 0.4 6.81 0.35 4.64e-11 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC cis rs208520 0.690 rs2144081 chr6:66824972 G/A cg07460842 chr6:66804631 NA -1.09 -15.06 -0.64 2.3e-39 Exhaled nitric oxide output; CRC cis rs8060686 0.545 rs9922165 chr16:68181177 C/A cg26727032 chr16:67993705 SLC12A4 -0.56 -7.48 -0.38 6.93e-13 HDL cholesterol;Metabolic syndrome; CRC cis rs6502050 0.865 rs8079388 chr17:80162798 C/A cg13198984 chr17:80129470 CCDC57 0.47 8.46 0.42 8.84e-16 Life satisfaction; CRC cis rs4660261 0.545 rs803682 chr1:44362623 G/A cg13606994 chr1:44402422 ARTN -0.34 -5.76 -0.3 1.96e-8 Intelligence (multi-trait analysis); CRC cis rs4737010 0.959 rs4737009 chr8:41630405 A/G cg17182837 chr8:41585554 ANK1 -0.48 -6.58 -0.34 1.87e-10 Lymphocyte counts;High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Reticulocyte count;Reticulocyte fraction of red cells;Mean corpuscular volume;Immature fraction of reticulocytes;Mean corpuscular hemoglobin concentration; CRC cis rs826838 0.616 rs2200605 chr12:38624088 G/A cg26384229 chr12:38710491 ALG10B 0.43 6.25 0.33 1.26e-9 Heart rate; CRC cis rs8180040 0.966 rs4858868 chr3:47455086 G/A cg27129171 chr3:47204927 SETD2 0.52 8.07 0.41 1.35e-14 Colorectal cancer; CRC cis rs7589728 0.514 rs12465706 chr2:88467459 C/A cg24977027 chr2:88469347 THNSL2 0.63 7.75 0.39 1.14e-13 Plasma clusterin levels; CRC trans rs9929218 0.581 rs4783676 chr16:68801077 A/C cg04657470 chr2:198365150 HSPE1;HSPD1 0.91 16.19 0.67 8.83e-44 Colorectal cancer; CRC cis rs798554 1.000 rs798536 chr7:2766383 G/A cg17321639 chr7:2759063 NA -0.51 -6.79 -0.35 5.35e-11 Height; CRC cis rs8180040 0.932 rs12489046 chr3:47527683 T/G cg27129171 chr3:47204927 SETD2 0.52 8.08 0.41 1.27e-14 Colorectal cancer; CRC cis rs34375054 0.624 rs12826658 chr12:125680237 A/G cg25124228 chr12:125621409 AACS -0.53 -6.92 -0.36 2.35e-11 Post bronchodilator FEV1/FVC ratio; CRC cis rs7552404 0.961 rs211710 chr1:76109038 G/A cg03433033 chr1:76189801 ACADM -0.81 -11.04 -0.52 2.48e-24 Blood metabolite levels;Acylcarnitine levels; CRC cis rs4481887 1.000 rs4244176 chr1:248468231 G/A cg13385794 chr1:248469461 NA 0.38 6.8 0.35 5.07e-11 Common traits (Other); CRC cis rs1256061 0.669 rs1256065 chr14:64698932 G/T cg23250157 chr14:64679961 SYNE2 0.44 6.76 0.35 6.15e-11 Hemoglobin concentration;Red blood cell count;Hematocrit; CRC cis rs2228479 0.850 rs45524643 chr16:89815824 G/A cg06656553 chr16:89960601 TCF25 -0.69 -5.74 -0.3 2.15e-8 Skin colour saturation; CRC cis rs4819052 0.851 rs2877020 chr21:46658742 C/T cg02159808 chr21:46707872 POFUT2;LOC642852 0.49 6.41 0.33 5.19e-10 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs1005277 0.540 rs1814077 chr10:37992018 G/C cg00409905 chr10:38381863 ZNF37A -0.63 -10.3 -0.49 9.61e-22 Extrinsic epigenetic age acceleration; CRC cis rs2739330 0.760 rs5760095 chr22:24247293 A/G cg24846343 chr22:24311635 DDTL 0.72 11.55 0.54 3.87e-26 Liver enzyme levels (gamma-glutamyl transferase); CRC trans rs11098499 0.955 rs1551 chr4:120158500 T/G cg25214090 chr10:38739885 LOC399744 0.52 8.1 0.41 1.05e-14 Corneal astigmatism; CRC cis rs611744 0.625 rs11779824 chr8:109278689 G/A cg18478394 chr8:109455254 TTC35 0.38 5.8 0.3 1.55e-8 Dupuytren's disease; CRC cis rs9733 0.519 rs2184833 chr1:150675483 C/T cg15448220 chr1:150897856 SETDB1 0.48 6.87 0.35 3.21e-11 Tonsillectomy; CRC cis rs2239547 0.562 rs6794389 chr3:53096394 A/G cg18404041 chr3:52824283 ITIH1 -0.34 -6.05 -0.32 3.95e-9 Schizophrenia; CRC cis rs1577917 1.000 rs6923148 chr6:86767786 A/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A 0.54 7.23 0.37 3.44e-12 Response to antipsychotic treatment; CRC cis rs1887596 0.705 rs1087258 chr13:27200006 T/C cg01312412 chr13:27282625 NA 0.43 5.81 0.31 1.44e-8 Facial morphology (factor 3, length of philtrum); CRC cis rs9868809 0.505 rs11708786 chr3:48752654 C/T cg07636037 chr3:49044803 WDR6 -0.63 -6.42 -0.33 4.8e-10 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; CRC cis rs972578 0.837 rs2073199 chr22:43275250 G/A cg01576275 chr22:43409880 NA -0.41 -6.48 -0.34 3.44e-10 Mean platelet volume; CRC cis rs12144094 0.766 rs74984954 chr1:120234068 G/A cg20995928 chr1:120229863 NA 0.49 6.98 0.36 1.59e-11 Height; CRC cis rs7618915 0.547 rs6762813 chr3:52726695 C/T cg18404041 chr3:52824283 ITIH1 -0.44 -8.97 -0.44 2.31e-17 Bipolar disorder; CRC cis rs4689388 0.926 rs11725494 chr4:6293855 C/T cg25554036 chr4:6271136 WFS1 0.51 8.22 0.41 4.66e-15 Type 2 diabetes and other traits;Type 2 diabetes; CRC cis rs10504229 0.683 rs6980540 chr8:58127022 A/G cg21724239 chr8:58056113 NA 0.49 6.77 0.35 5.94e-11 Developmental language disorder (linguistic errors); CRC cis rs7786877 0.500 rs2272572 chr7:100285888 C/T cg20848291 chr7:100343083 ZAN -0.65 -9.72 -0.47 8.32e-20 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs11226613 0.547 rs3913640 chr11:104988630 T/A cg04181079 chr11:104896587 CASP1 0.41 5.62 0.3 4.17e-8 Bronchopulmonary dysplasia; CRC cis rs1552244 0.882 rs66559400 chr3:10012551 G/A cg13047869 chr3:10149882 C3orf24 0.51 6.97 0.36 1.74e-11 Alzheimer's disease; CRC cis rs9487051 0.676 rs6913093 chr6:109636205 T/C cg01475377 chr6:109611718 NA -0.37 -6.41 -0.33 5.16e-10 Reticulocyte fraction of red cells; CRC cis rs9487051 0.676 rs1829694 chr6:109593860 G/T cg12927641 chr6:109611667 NA -0.36 -6.44 -0.33 4.15e-10 Reticulocyte fraction of red cells; CRC cis rs17125944 0.505 rs2295827 chr14:53174981 C/T cg00686598 chr14:53173677 PSMC6 1.24 11.54 0.54 4.15e-26 Alzheimer's disease (late onset); CRC cis rs11155671 0.530 rs9383577 chr6:150207195 C/T cg07701084 chr6:150067640 NUP43 0.49 7.17 0.37 4.95e-12 Testicular germ cell tumor; CRC cis rs12325245 0.536 rs35432891 chr16:58561966 G/A cg02549819 chr16:58548995 SETD6 1.13 7.37 0.38 1.43e-12 Schizophrenia; CRC cis rs12477438 0.520 rs4402818 chr2:99717608 A/G cg14399236 chr2:99771627 LIPT1;TSGA10 0.78 13.66 0.6 5.74e-34 Chronic sinus infection; CRC cis rs1519814 1.000 rs12678023 chr8:121123494 G/A cg22335954 chr8:121166405 COL14A1 -0.49 -6.1 -0.32 3.06e-9 Breast cancer; CRC cis rs7916697 0.520 rs10762201 chr10:70040111 A/G cg06988349 chr10:69991859 ATOH7 -0.36 -6.31 -0.33 8.93e-10 Optic disc area; CRC cis rs6952808 1.000 rs4449693 chr7:1884630 G/C cg22963979 chr7:1858916 MAD1L1 -0.65 -10.01 -0.48 9.17e-21 Bipolar disorder and schizophrenia; CRC cis rs1550582 1.000 rs754234 chr8:135512875 A/G cg17885191 chr8:135476712 NA 0.72 8.27 0.41 3.42e-15 Educational attainment; CRC cis rs10256972 0.552 rs2960837 chr7:1203957 A/G cg23708337 chr7:1209742 NA 0.51 7.97 0.4 2.57e-14 Longevity;Endometriosis; CRC cis rs6502050 0.835 rs62080004 chr17:80079079 C/T cg22110888 chr17:80059540 CCDC57 -0.41 -6.38 -0.33 6.13e-10 Life satisfaction; CRC cis rs56399783 0.901 rs79932907 chr7:2827901 C/G cg23627948 chr7:2760692 NA 0.47 5.64 0.3 3.75e-8 Childhood ear infection; CRC cis rs1862618 0.802 rs986049 chr5:56110233 G/A cg20203395 chr5:56204925 C5orf35 -0.69 -8.24 -0.41 4.08e-15 Initial pursuit acceleration; CRC cis rs10883723 0.738 rs715438 chr10:104258303 C/T cg04362960 chr10:104952993 NT5C2 -0.41 -5.72 -0.3 2.37e-8 Allergic disease (asthma, hay fever or eczema); CRC cis rs11098499 0.955 rs35916640 chr4:120155852 T/C cg09307838 chr4:120376055 NA 0.63 9.72 0.47 8.33e-20 Corneal astigmatism; CRC cis rs34779708 0.966 rs7913615 chr10:35422957 T/G cg03585969 chr10:35415529 CREM 0.61 8.15 0.41 7.69e-15 Inflammatory bowel disease;Crohn's disease; CRC cis rs3096299 0.685 rs3803682 chr16:89544636 C/T cg01788221 chr16:89496183 ANKRD11 -0.4 -6.02 -0.31 4.66e-9 Multiple myeloma (IgH translocation); CRC cis rs4332037 0.707 rs4721096 chr7:1877311 T/C cg25834613 chr7:1915315 MAD1L1 0.41 6.03 0.32 4.38e-9 Bipolar disorder; CRC cis rs2745967 0.755 rs2724368 chr1:208072697 G/A cg09788693 chr1:208063733 CD34 0.42 6.43 0.33 4.41e-10 Resting heart rate; CRC cis rs9322193 0.923 rs10782314 chr6:150056663 C/T cg05861140 chr6:150128134 PCMT1 -0.4 -6.37 -0.33 6.41e-10 Lung cancer; CRC cis rs7615952 0.599 rs2279821 chr3:125734308 G/A cg02807482 chr3:125708958 NA -0.46 -5.76 -0.3 1.95e-8 Blood pressure (smoking interaction); CRC cis rs7937682 0.562 rs10891276 chr11:111370415 A/C cg09085632 chr11:111637200 PPP2R1B -0.59 -8.81 -0.44 7.5e-17 Primary sclerosing cholangitis; CRC cis rs11212617 1.000 rs600931 chr11:108117335 C/T cg14761454 chr11:108092087 ATM;NPAT 0.43 6.34 0.33 7.78e-10 Response to metformin in type 2 diabetes (glycemic); CRC cis rs514406 0.861 rs503015 chr1:53254456 T/C cg24675658 chr1:53192096 ZYG11B 0.56 8.16 0.41 6.94e-15 Monocyte count; CRC cis rs10905065 0.861 rs10752069 chr10:5752403 A/G cg11519256 chr10:5708881 ASB13 0.53 7.7 0.39 1.63e-13 Menopause (age at onset); CRC cis rs2576037 0.544 rs629097 chr18:44378097 T/C cg19077165 chr18:44547161 KATNAL2 -0.58 -9.64 -0.47 1.61e-19 Personality dimensions; CRC cis rs2070677 0.935 rs2864985 chr10:135348757 C/G cg16964102 chr10:135390573 NA -0.48 -6.54 -0.34 2.41e-10 Gout; CRC cis rs11122272 0.735 rs2572251 chr1:231514243 C/T cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.54 -8.11 -0.41 1.04e-14 Hemoglobin concentration; CRC cis rs35264875 0.808 rs921675 chr11:68869034 A/G cg03469862 chr11:68924853 NA -0.37 -5.71 -0.3 2.51e-8 Blond vs. brown hair color; CRC cis rs9372498 0.505 rs9320655 chr6:118830981 T/C cg07617317 chr6:118971624 C6orf204 0.5 6.25 0.33 1.25e-9 Diastolic blood pressure; CRC cis rs3091242 0.728 rs706845 chr1:25730713 G/A cg23205692 chr1:25664452 TMEM50A 0.41 5.79 0.3 1.68e-8 Erythrocyte sedimentation rate; CRC cis rs6952808 0.792 rs4421257 chr7:1955152 T/C cg00106254 chr7:1943704 MAD1L1 -0.44 -6.74 -0.35 6.94e-11 Bipolar disorder and schizophrenia; CRC cis rs9303401 0.659 rs12948133 chr17:56673602 T/C cg02118635 chr17:56770003 RAD51C;TEX14 0.78 9.61 0.47 1.92e-19 Cognitive test performance; CRC trans rs2228479 0.850 rs17233567 chr16:89813821 G/A cg21302420 chr1:112162376 RAP1A 0.72 6.01 0.31 5.05e-9 Skin colour saturation; CRC cis rs9522267 0.535 rs914037 chr13:112235308 A/G cg14352298 chr13:112236639 NA 0.29 6.74 0.35 7.32e-11 Hepatitis; CRC cis rs6028335 0.674 rs68173814 chr20:37621180 A/G cg16355469 chr20:37678765 NA 0.46 5.62 0.3 4.01e-8 Alcohol and nicotine co-dependence; CRC cis rs2976388 1.000 rs2920295 chr8:143764937 A/G cg22687807 chr8:143858763 LYNX1 -0.39 -6.8 -0.35 5e-11 Urinary tract infection frequency; CRC cis rs11148252 0.564 rs2296350 chr13:52710044 T/C cg02158880 chr13:53174818 NA 0.39 5.6 0.3 4.51e-8 Lewy body disease; CRC cis rs1559088 0.600 rs10421769 chr19:33605312 T/C cg27124370 chr19:33622961 WDR88 0.47 6.79 0.35 5.13e-11 Bone ultrasound measurement (broadband ultrasound attenuation); CRC cis rs11122272 0.735 rs2790885 chr1:231529925 C/T cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.58 -8.75 -0.43 1.1e-16 Hemoglobin concentration; CRC trans rs6703335 0.870 rs10803142 chr1:243598234 A/G cg16669491 chr19:19314215 NR2C2AP 0.45 6.36 0.33 6.74e-10 Schizophrenia;Schizophrenia, schizoaffective disorder or bipolar disorder; CRC cis rs2274273 0.870 rs4597235 chr14:55851987 A/G cg23234261 chr14:55582407 NA -0.29 -5.65 -0.3 3.54e-8 Protein biomarker; CRC cis rs970548 1.000 rs10900224 chr10:46024534 C/T cg15590007 chr10:45870220 ALOX5 0.5 6.43 0.33 4.5e-10 Total cholesterol levels;Cholesterol, total;HDL cholesterol;HDL cholesterol levels; CRC cis rs9549367 0.865 rs3861721 chr13:113906308 C/T cg00898013 chr13:113819073 PROZ -0.46 -6.47 -0.34 3.56e-10 Platelet distribution width; CRC cis rs9467711 0.722 rs35825164 chr6:26117404 T/C cg16898833 chr6:26189333 HIST1H4D 0.67 5.91 0.31 8.41e-9 Autism spectrum disorder or schizophrenia; CRC cis rs8180040 0.726 rs7625070 chr3:47095518 A/G cg27129171 chr3:47204927 SETD2 0.77 13.18 0.59 3.72e-32 Colorectal cancer; CRC cis rs9443645 0.869 rs9361467 chr6:79621098 A/G cg05283184 chr6:79620031 NA -0.57 -9.15 -0.45 6.22e-18 Intelligence (multi-trait analysis); CRC cis rs6964587 1.000 rs3753109 chr7:91630001 G/C cg17063962 chr7:91808500 NA 0.8 14.23 0.62 3.95e-36 Breast cancer; CRC cis rs2398893 0.889 rs7872984 chr9:96782447 T/C cg14459158 chr9:96720562 NA 0.41 6.81 0.35 4.57e-11 Waist-hip ratio;Waist-to-hip ratio adjusted for body mass index; CRC cis rs2795502 1.000 rs2795508 chr10:43353555 G/T cg20628663 chr10:43360327 NA 0.6 9.62 0.47 1.81e-19 Blood protein levels; CRC cis rs1401999 0.690 rs6773408 chr3:183716609 G/T cg05044414 chr3:183734942 ABCC5 0.4 7.02 0.36 1.3e-11 Anterior chamber depth; CRC cis rs2708977 0.966 rs749027 chr2:97203137 A/C cg01950434 chr2:97203154 ARID5A -0.49 -7.17 -0.37 4.98e-12 Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes; CRC cis rs898097 0.805 rs60233158 chr17:80896612 A/G cg16060761 chr17:80687452 NA -0.47 -6.8 -0.35 4.99e-11 Breast cancer; CRC cis rs9943753 0.525 rs7952909 chr12:109808573 A/T cg19025524 chr12:109796872 NA 0.54 8.47 0.42 8.49e-16 HDL cholesterol; CRC cis rs4654899 0.965 rs7525620 chr1:21458392 G/A cg02927042 chr1:21476669 EIF4G3 -0.47 -7.58 -0.39 3.67e-13 Superior frontal gyrus grey matter volume; CRC cis rs1552244 0.882 rs6443276 chr3:10008905 C/A cg02579736 chr3:10068473 FANCD2;CIDECP 0.92 11.97 0.55 1.17e-27 Alzheimer's disease; CRC cis rs2735413 0.875 rs12924402 chr16:78083477 C/G cg04733911 chr16:78082701 NA -0.46 -7.58 -0.39 3.54e-13 Systolic blood pressure (alcohol consumption interaction); CRC cis rs2732480 0.577 rs2732457 chr12:48758379 A/G cg04545296 chr12:48745243 ZNF641 -0.36 -6.16 -0.32 2.15e-9 Hemoglobin concentration;Red blood cell count;Hematocrit; CRC cis rs6783573 0.683 rs3806702 chr3:46617502 T/C cg27371741 chr3:46619158 LRRC2;TDGF1 -0.44 -5.94 -0.31 7.2e-9 Cerebrospinal fluid biomarker levels; CRC cis rs7412746 0.658 rs17660092 chr1:150797748 T/C cg17724175 chr1:150552817 MCL1 0.49 7.25 0.37 2.95e-12 Melanoma; CRC cis rs10256972 0.552 rs2960831 chr7:1201192 A/T cg03923535 chr7:1197113 ZFAND2A 0.71 10.63 0.51 7.07e-23 Longevity;Endometriosis; CRC cis rs243505 0.898 rs243535 chr7:148410123 A/C cg09806900 chr7:148480153 CUL1 -0.43 -6.01 -0.31 4.84e-9 Inflammatory bowel disease;Crohn's disease; CRC cis rs847577 0.609 rs11768309 chr7:97773812 G/T cg00277769 chr7:97922759 BAIAP2L1 -0.39 -6.51 -0.34 2.74e-10 Breast cancer; CRC cis rs875971 0.862 rs6958294 chr7:65794796 C/A cg18252515 chr7:66147081 NA 0.42 5.96 0.31 6.5e-9 Aortic root size; CRC cis rs12745968 0.532 rs4970704 chr1:92971702 T/A cg17283838 chr1:93427260 FAM69A -0.48 -6.52 -0.34 2.72e-10 Bipolar disorder and schizophrenia; CRC cis rs7666738 0.830 rs4699580 chr4:98930673 T/C cg17366294 chr4:99064904 C4orf37 0.43 7.32 0.37 1.95e-12 Colonoscopy-negative controls vs population controls; CRC cis rs9549367 0.707 rs9549353 chr13:113843427 G/A cg18105134 chr13:113819100 PROZ -0.86 -12.44 -0.57 2.22e-29 Platelet distribution width; CRC cis rs12142240 0.698 rs17357759 chr1:46832534 A/G cg00530320 chr1:46809349 NSUN4 0.55 7.4 0.38 1.18e-12 Menopause (age at onset); CRC trans rs11098499 0.691 rs17009144 chr4:120270795 C/T cg25214090 chr10:38739885 LOC399744 -0.54 -8.62 -0.43 2.86e-16 Corneal astigmatism; CRC cis rs4689592 0.554 rs66925245 chr4:7071999 C/T cg06697600 chr4:7070879 GRPEL1 0.55 7.27 0.37 2.63e-12 Monocyte percentage of white cells; CRC cis rs34526934 0.608 rs7591820 chr2:177028144 G/T cg14324370 chr2:177042789 NA -0.69 -9.35 -0.46 1.34e-18 Obstructive sleep apnea trait (apnea hypopnea index); CRC trans rs9329221 0.537 rs13264586 chr8:9979385 T/C cg06636001 chr8:8085503 FLJ10661 0.47 6.89 0.36 2.92e-11 Neuroticism; CRC cis rs10752881 1.000 rs10752883 chr1:182980963 G/A ch.1.3577855R chr1:183094577 LAMC1 0.87 15.17 0.64 9.03e-40 Colorectal cancer; CRC cis rs6938 0.534 rs8025447 chr15:75192222 T/G cg17294928 chr15:75287854 SCAMP5 0.52 8.06 0.41 1.43e-14 Breast cancer; CRC cis rs4731207 0.698 rs12154816 chr7:124478299 G/A cg23710748 chr7:124431027 NA 0.38 6.08 0.32 3.42e-9 Cutaneous malignant melanoma; CRC cis rs68170813 0.559 rs6964966 chr7:106933099 C/G cg02696742 chr7:106810147 HBP1 -0.6 -6.65 -0.34 1.25e-10 Coronary artery disease; CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg14036097 chr4:190862158 FRG1 0.36 6.02 0.31 4.63e-9 Obesity-related traits; CRC cis rs10751667 0.600 rs10902264 chr11:1003523 G/A ch.11.42038R chr11:967971 AP2A2 0.58 9.15 0.45 6.28e-18 Alzheimer's disease (late onset); CRC cis rs6694672 1.000 rs9427660 chr1:196946420 T/A cg13682187 chr1:196946512 CFHR5 -0.5 -7.97 -0.4 2.59e-14 Asthma; CRC cis rs7843479 0.601 rs11781959 chr8:21841863 C/G cg16476235 chr8:21771668 DOK2 0.38 6.53 0.34 2.48e-10 Mean corpuscular volume; CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg09071838 chr13:25497213 CENPJ 0.42 6.72 0.35 8.1e-11 Obesity-related traits; CRC cis rs12477438 0.798 rs9679602 chr2:99577827 C/T cg26064155 chr2:99771622 LIPT1;TSGA10 0.74 10.36 0.5 5.72e-22 Chronic sinus infection; CRC cis rs4555082 0.718 rs28513571 chr14:105709592 C/A cg13114125 chr14:105738426 BRF1 -0.77 -11.43 -0.53 1.1e-25 Mean platelet volume;Platelet distribution width; CRC trans rs875971 0.660 rs2191268 chr7:66110224 C/T cg19195327 chr1:6479725 HES2 -0.41 -6.81 -0.35 4.62e-11 Aortic root size; CRC cis rs6866344 0.697 rs11749438 chr5:178131245 C/T cg10224037 chr5:178157518 ZNF354A 0.78 11.11 0.52 1.48e-24 Neutrophil percentage of white cells; CRC cis rs2635047 0.569 rs9958817 chr18:44786481 G/A cg19077165 chr18:44547161 KATNAL2 -0.39 -6.11 -0.32 2.77e-9 Educational attainment; CRC cis rs8062405 1.000 rs56358680 chr16:28843118 A/G cg08761264 chr16:28874980 SH2B1 -0.42 -5.63 -0.3 3.83e-8 Cognitive ability (multi-trait analysis);Cognitive ability; CRC cis rs1799949 1.000 rs8176265 chr17:41213996 C/T cg05368731 chr17:41323189 NBR1 0.65 9.53 0.47 3.61e-19 Menopause (age at onset); CRC cis rs1003719 0.788 rs7275582 chr21:38451130 C/T cg10648535 chr21:38446584 PIGP;TTC3 0.53 7.43 0.38 9.57e-13 Eye color traits; CRC cis rs12541635 1.000 rs4734897 chr8:107075518 G/A cg10147462 chr8:107024639 NA -0.38 -6.41 -0.33 5.1e-10 Age of smoking initiation; CRC cis rs7044106 0.762 rs4837790 chr9:123446325 C/T cg09586646 chr9:123605570 PSMD5;LOC253039 0.6 8.81 0.44 7.43e-17 Hip circumference adjusted for BMI; CRC cis rs875971 0.929 rs6970860 chr7:65976634 A/G cg18876405 chr7:65276391 NA 0.51 8.78 0.44 9.39e-17 Aortic root size; CRC cis rs10242455 0.702 rs28460612 chr7:98993205 C/G cg18809830 chr7:99032528 PTCD1 -1.11 -7.93 -0.4 3.46e-14 Blood metabolite levels; CRC cis rs10751667 0.666 rs6597967 chr11:950583 G/T cg06064525 chr11:970664 AP2A2 -0.33 -6.76 -0.35 6.25e-11 Alzheimer's disease (late onset); CRC cis rs1018836 0.923 rs7837230 chr8:91574281 C/T cg16814680 chr8:91681699 NA -0.73 -11.65 -0.54 1.69e-26 Ejection fraction in Tripanosoma cruzi seropositivity; CRC cis rs2991971 0.810 rs6657237 chr1:45920108 A/T cg15605315 chr1:45957053 TESK2 -0.38 -5.94 -0.31 7.19e-9 High light scatter reticulocyte count; CRC cis rs9443645 0.808 rs2050661 chr6:79661125 T/C cg11833968 chr6:79620685 NA -0.36 -6.16 -0.32 2.15e-9 Intelligence (multi-trait analysis); CRC cis rs4604732 0.631 rs11490199 chr1:247625737 A/G cg12758973 chr1:247694275 LOC148824;OR2C3 0.42 6.14 0.32 2.32e-9 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CRC cis rs7208859 0.673 rs216420 chr17:28938508 C/T cg26176469 chr17:28951361 LRRC37B2 0.56 6.11 0.32 2.81e-9 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs7605827 0.866 rs9710889 chr2:15533779 G/A cg19274914 chr2:15703543 NA 0.39 5.87 0.31 1.09e-8 Educational attainment (years of education); CRC cis rs9733 0.596 rs12089989 chr1:150715782 G/A cg17724175 chr1:150552817 MCL1 0.51 7.93 0.4 3.37e-14 Tonsillectomy; CRC cis rs10256972 0.616 rs4585652 chr7:1145396 A/G cg07308232 chr7:1071921 C7orf50 -0.46 -6.1 -0.32 2.98e-9 Longevity;Endometriosis; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg22416137 chr6:52930106 FBXO9 0.46 6.03 0.32 4.46e-9 Anxiety disorder; CRC cis rs2882667 0.898 rs11952020 chr5:138395156 A/T cg09476006 chr5:138032270 NA 0.45 7.67 0.39 1.99e-13 Age-related hearing impairment (SNP x SNP interaction); CRC trans rs17685 0.753 rs1637044 chr7:75703744 T/C cg19862616 chr7:65841803 NCRNA00174 0.99 18.51 0.71 6.2e-53 Coffee consumption;Coffee consumption (cups per day); CRC cis rs11229555 0.574 rs11603800 chr11:58202085 A/G cg15696309 chr11:58395628 NA -0.82 -10.31 -0.49 8.59e-22 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg00370926 chr17:7835519 TRAPPC1;CNTROB 0.41 7.02 0.36 1.3e-11 Liver disease severity in Alagille syndrome; CRC trans rs8073060 0.586 rs225296 chr17:33924847 C/G cg19694781 chr19:47549865 TMEM160 -1.03 -14.7 -0.63 6.17e-38 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; CRC cis rs7666738 0.830 rs7679299 chr4:99057620 C/A cg05340658 chr4:99064831 C4orf37 0.6 9.25 0.45 2.97e-18 Colonoscopy-negative controls vs population controls; CRC cis rs1728785 0.901 rs698711 chr16:68561955 C/T cg02972257 chr16:68554789 NA -0.59 -7.34 -0.38 1.71e-12 Ulcerative colitis; CRC cis rs6500602 0.702 rs4786511 chr16:4571645 C/T cg14951292 chr16:4525986 HMOX2;NMRAL1 0.58 8.83 0.44 6.16e-17 Schizophrenia; CRC cis rs1218582 0.711 rs4845677 chr1:154838050 C/T cg03351412 chr1:154909251 PMVK 0.48 7.64 0.39 2.38e-13 Prostate cancer; CRC cis rs4665809 0.938 rs4665822 chr2:26312555 C/G cg22920501 chr2:26401640 FAM59B -0.53 -7.16 -0.37 5.17e-12 Gut microbiome composition (summer); CRC cis rs6952808 0.723 rs11766575 chr7:2005747 T/C cg02951883 chr7:2050386 MAD1L1 -0.75 -11.91 -0.55 1.91e-27 Bipolar disorder and schizophrenia; CRC cis rs12760731 0.623 rs12045201 chr1:178399218 A/G cg00404053 chr1:178313656 RASAL2 0.69 8.27 0.41 3.3e-15 Obesity-related traits; CRC cis rs67311347 0.956 rs6771527 chr3:40506548 T/C cg09455208 chr3:40491958 NA -0.48 -9.49 -0.46 4.92e-19 Renal cell carcinoma; CRC cis rs9894429 0.621 rs9747119 chr17:79607017 A/G cg13777783 chr17:79615861 NA -0.31 -5.73 -0.3 2.27e-8 Eye color traits; CRC cis rs2153535 0.584 rs9502721 chr6:8541379 G/A cg21535247 chr6:8435926 SLC35B3 0.5 7.62 0.39 2.72e-13 Motion sickness; CRC cis rs1448094 0.511 rs17345299 chr12:86166005 C/G cg18827107 chr12:86230957 RASSF9 -0.39 -5.99 -0.31 5.37e-9 Major depressive disorder; CRC cis rs3741151 0.686 rs7935948 chr11:73219118 A/G cg17517138 chr11:73019481 ARHGEF17 -0.55 -6.18 -0.32 1.86e-9 GIP levels in response to oral glucose tolerance test (120 minutes); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg14196303 chr9:6757347 KDM4C 0.45 6.27 0.33 1.12e-9 Response to antipsychotic treatment; CRC cis rs12580194 0.593 rs56677471 chr12:55749967 T/A cg19537932 chr12:55886519 OR6C68 -0.69 -8.95 -0.44 2.63e-17 Cancer; CRC trans rs75246769 0.706 rs76040643 chr7:145679110 A/C cg14916917 chr5:81574294 RPS23 0.91 6.28 0.33 1.09e-9 Facial morphology (factor 10, width of nasal floor); CRC cis rs68170813 0.559 rs78267892 chr7:106823734 C/T cg02696742 chr7:106810147 HBP1 -0.64 -7.2 -0.37 4.19e-12 Coronary artery disease; CRC trans rs11098499 0.691 rs10028773 chr4:120265259 C/G cg25214090 chr10:38739885 LOC399744 -0.51 -8.1 -0.41 1.11e-14 Corneal astigmatism; CRC cis rs2050392 0.767 rs10763787 chr10:30700753 G/A cg18806716 chr10:30721971 MAP3K8 0.68 9.94 0.48 1.57e-20 Inflammatory bowel disease; CRC trans rs10411161 0.810 rs77458785 chr19:52384295 T/G cg22319618 chr22:45562946 NUP50 -0.69 -6.01 -0.31 4.9e-9 Breast cancer; CRC cis rs6060960 0.502 rs6057968 chr20:30082779 A/T cg13852791 chr20:30311386 BCL2L1 0.54 7.81 0.4 7.96e-14 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; CRC cis rs877282 0.898 rs11253344 chr10:765162 C/T cg06581033 chr10:766294 NA -0.53 -5.88 -0.31 1.01e-8 Uric acid levels; CRC cis rs1552244 0.515 rs67626468 chr3:10161518 C/A cg18598329 chr3:10140678 FANCD2;C3orf24 -0.91 -10.85 -0.51 1.16e-23 Alzheimer's disease; CRC cis rs6570726 0.791 rs13202312 chr6:145913093 T/G cg05347473 chr6:146136440 FBXO30 0.39 5.89 0.31 9.49e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs9291683 0.588 rs35099040 chr4:10018839 T/C cg00071950 chr4:10020882 SLC2A9 0.68 13.12 0.59 6.59e-32 Bone mineral density; CRC cis rs9399135 1.000 rs11754265 chr6:135356216 C/G cg24558204 chr6:135376177 HBS1L 0.49 7.63 0.39 2.5e-13 Red blood cell count; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg15790941 chr4:39640517 C4orf34 0.37 6.08 0.32 3.34e-9 Liver disease severity in Alagille syndrome; CRC trans rs11098499 0.954 rs878373 chr4:120237484 A/T cg25214090 chr10:38739885 LOC399744 0.61 9.36 0.46 1.3e-18 Corneal astigmatism; CRC cis rs28386778 0.830 rs7209321 chr17:61855668 A/C cg22520471 chr17:61851767 DDX42;CCDC47 0.75 11.4 0.53 1.38e-25 Prudent dietary pattern; CRC cis rs524281 0.773 rs2155198 chr11:66014300 C/T cg16950941 chr11:66035639 RAB1B -0.7 -8.04 -0.41 1.67e-14 Electroencephalogram traits; CRC cis rs6952808 0.929 rs11761270 chr7:1923695 C/T cg02951883 chr7:2050386 MAD1L1 -0.73 -12.01 -0.55 8.3e-28 Bipolar disorder and schizophrenia; CRC cis rs3733585 0.631 rs7699671 chr4:10125874 C/T cg00071950 chr4:10020882 SLC2A9 -0.53 -8.66 -0.43 2.18e-16 Cleft plate (environmental tobacco smoke interaction); CRC cis rs3751196 0.901 rs12422418 chr12:104202160 C/T cg02344784 chr12:104178138 NT5DC3 0.69 7.05 0.36 1.06e-11 Sense of smell; CRC cis rs2836974 0.568 rs371625 chr21:40535271 A/G cg11644478 chr21:40555479 PSMG1 -0.72 -12.17 -0.56 2.17e-28 Cognitive function; CRC cis rs4819052 0.851 rs13052312 chr21:46662359 T/C cg11663144 chr21:46675770 NA -0.83 -14.01 -0.61 2.7900000000000003e-35 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs3820068 0.532 rs78917815 chr1:15920821 A/G cg13390004 chr1:15929781 NA 0.49 6.79 0.35 5.28e-11 Systolic blood pressure; CRC cis rs853679 0.550 rs6901017 chr6:28152583 T/C cg15845792 chr6:28175446 NA 1.02 14.65 0.63 8.95e-38 Depression; CRC cis rs7618501 0.966 rs9882639 chr3:49799475 A/C cg24308560 chr3:49941425 MST1R -0.47 -7.44 -0.38 9e-13 Intelligence (multi-trait analysis); CRC cis rs3018066 0.867 rs13121614 chr4:107166246 G/A cg01869342 chr4:106983673 TBCK -0.36 -5.66 -0.3 3.37e-8 Cancer; CRC cis rs7811142 0.830 rs7792959 chr7:99972403 C/T cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.75 10.58 0.5 1.02e-22 Platelet count; CRC cis rs17270561 0.609 rs12203927 chr6:25732690 A/G cg16482183 chr6:26056742 HIST1H1C 0.83 10.58 0.5 1.07e-22 Iron status biomarkers; CRC cis rs1552244 0.554 rs7638846 chr3:10048601 A/G cg16606324 chr3:10149918 C3orf24 0.49 7.24 0.37 3.24e-12 Alzheimer's disease; CRC cis rs7085104 0.700 rs743572 chr10:104597152 A/G cg04362960 chr10:104952993 NT5C2 0.6 8.88 0.44 4.54e-17 Immature fraction of reticulocytes;Schizophrenia; CRC trans rs4650994 1.000 rs17361251 chr1:178520577 C/A cg05059571 chr16:84539110 KIAA1609 -0.48 -7.3 -0.37 2.17e-12 HDL cholesterol levels;HDL cholesterol; CRC cis rs11098499 0.739 rs7441137 chr4:120133221 G/T cg09307838 chr4:120376055 NA -0.53 -8.27 -0.41 3.39e-15 Corneal astigmatism; CRC cis rs5758659 0.714 rs133373 chr22:42465788 G/A cg04733989 chr22:42467013 NAGA 0.41 5.74 0.3 2.15e-8 Cognitive function; CRC cis rs56114371 0.568 rs200468 chr6:27757855 C/G cg06470822 chr6:28175283 NA 0.59 6.9 0.36 2.61e-11 Breast cancer; CRC cis rs72627123 0.867 rs61522544 chr14:74481953 G/A cg12022184 chr14:74485813 ENTPD5;C14orf45 0.72 6.19 0.32 1.8e-9 Morning vs. evening chronotype; CRC cis rs6840360 0.642 rs1443088 chr4:152450126 G/A cg09659197 chr4:152720779 NA 0.33 6.49 0.34 3.21e-10 Intelligence (multi-trait analysis); CRC cis rs2976388 1.000 rs1045531 chr8:143763547 C/A cg24046110 chr8:143859143 LYNX1 -0.37 -6.32 -0.33 8.7e-10 Urinary tract infection frequency; CRC cis rs1008375 1.000 rs12507142 chr4:17656103 A/G cg04450456 chr4:17643702 FAM184B 0.35 5.63 0.3 3.86e-8 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs9916302 0.904 rs585961 chr17:37444036 G/A cg07936489 chr17:37558343 FBXL20 0.84 13.19 0.59 3.46e-32 Glomerular filtration rate (creatinine); CRC cis rs185694 1.000 rs846498 chr13:30900541 A/G cg07600127 chr13:30881527 KATNAL1 -0.57 -6.05 -0.32 4.01e-9 Antineutrophil cytoplasmic antibody-associated vasculitis; CRC cis rs875971 0.638 rs10249404 chr7:66046724 G/A cg25985355 chr7:65971099 NA 0.32 5.71 0.3 2.54e-8 Aortic root size; CRC cis rs4692589 0.606 rs13127322 chr4:170935169 C/T cg19918862 chr4:170955249 NA 0.53 7.06 0.36 9.78e-12 Anxiety disorder; CRC cis rs853679 0.517 rs3757185 chr6:28107776 T/A cg15786705 chr6:28176104 NA 0.77 9.75 0.47 6.92e-20 Depression; CRC cis rs5769707 0.521 rs6009810 chr22:50059540 A/G cg20744362 chr22:50050164 C22orf34 0.35 6.4 0.33 5.29e-10 Monocyte count;Monocyte percentage of white cells; CRC cis rs4076764 0.801 rs4571944 chr1:163367975 T/C cg24596788 chr1:163392923 NA -0.63 -10.34 -0.5 6.76e-22 Motion sickness; CRC cis rs3806843 0.576 rs246017 chr5:140335060 C/T cg19875535 chr5:140030758 IK 0.4 6.12 0.32 2.64e-9 Depressive symptoms (multi-trait analysis); CRC cis rs7927592 0.763 rs10896327 chr11:68235275 G/C cg16797656 chr11:68205561 LRP5 0.51 9.63 0.47 1.66e-19 Total body bone mineral density; CRC cis rs9649465 0.561 rs2429620 chr7:123430012 A/G cg03229431 chr7:123269106 ASB15 0.5 7.96 0.4 2.75e-14 Migraine; CRC cis rs12701220 0.894 rs12701406 chr7:1050283 G/A cg26769984 chr7:1090371 C7orf50 0.68 8.97 0.44 2.32e-17 Bronchopulmonary dysplasia; CRC cis rs896854 0.654 rs2011566 chr8:95971921 G/A cg16049864 chr8:95962084 TP53INP1 -0.64 -11.8 -0.55 5e-27 Type 2 diabetes; CRC cis rs6582630 0.537 rs1949611 chr12:38373092 C/T cg13010199 chr12:38710504 ALG10B -0.48 -7.02 -0.36 1.27e-11 Drug-induced liver injury (flucloxacillin); CRC trans rs2303319 0.504 rs55841284 chr2:162560011 A/G cg18122310 chr12:50236657 BCDIN3D -0.74 -6.45 -0.34 4.07e-10 Cognitive function; CRC cis rs4936891 0.557 rs470242 chr11:123909342 G/A cg22125253 chr11:123886957 OR10G4 -0.34 -6.03 -0.32 4.33e-9 Male fertility; CRC cis rs6964587 1.000 rs3753107 chr7:91629151 C/T cg17063962 chr7:91808500 NA -0.82 -14.76 -0.63 3.49e-38 Breast cancer; CRC cis rs6582630 0.537 rs3942440 chr12:38459672 A/G cg26384229 chr12:38710491 ALG10B 0.72 10.09 0.49 4.78e-21 Drug-induced liver injury (flucloxacillin); CRC cis rs4713118 0.587 rs61471148 chr6:28037032 T/A cg12172441 chr6:28176163 NA 0.57 7.0 0.36 1.49e-11 Parkinson's disease; CRC cis rs6831352 0.918 rs13140423 chr4:100050400 T/C cg13256891 chr4:100009986 ADH5 -0.66 -8.89 -0.44 4.04e-17 Alcohol dependence; CRC cis rs7626444 0.625 rs843540 chr3:196475313 C/A cg12930392 chr3:196481615 PAK2 0.4 7.26 0.37 2.74e-12 Monocyte count; CRC cis rs503341 0.756 rs11231591 chr11:63587986 G/T cg04362095 chr11:63592001 C11orf84 -0.55 -8.9 -0.44 3.96e-17 Pulse pressure; CRC cis rs7786808 0.741 rs62479982 chr7:158227546 A/G cg09998033 chr7:158218633 PTPRN2 -0.62 -8.86 -0.44 5.28e-17 Obesity-related traits; CRC cis rs11971779 0.680 rs6467846 chr7:139079385 G/T cg07862535 chr7:139043722 LUC7L2 0.57 7.35 0.38 1.61e-12 Diisocyanate-induced asthma; CRC cis rs9916302 0.904 rs1077715 chr17:37683548 A/T cg15445000 chr17:37608096 MED1 0.41 8.84 0.44 5.95e-17 Glomerular filtration rate (creatinine); CRC cis rs875971 1.000 rs6958484 chr7:65599446 G/A cg11764359 chr7:65958608 NA -0.59 -9.45 -0.46 6.41e-19 Aortic root size; CRC cis rs7666738 0.830 rs11935588 chr4:98979862 A/G cg05340658 chr4:99064831 C4orf37 -0.59 -8.97 -0.44 2.36e-17 Colonoscopy-negative controls vs population controls; CRC cis rs17376456 0.569 rs2045019 chr5:93201971 C/T cg09848695 chr5:92956644 FAM172A;MIR2277 -0.53 -6.13 -0.32 2.56e-9 Diabetic retinopathy; CRC cis rs1552244 0.882 rs34779351 chr3:10021801 A/G cg10729496 chr3:10149963 C3orf24 0.48 6.25 0.33 1.25e-9 Alzheimer's disease; CRC cis rs3768617 0.966 rs6669796 chr1:183082825 G/C ch.1.3577855R chr1:183094577 LAMC1 0.61 9.31 0.46 1.89e-18 Fuchs's corneal dystrophy; CRC cis rs1707322 0.686 rs3014236 chr1:46091305 T/C cg06784218 chr1:46089804 CCDC17 -0.67 -12.22 -0.56 1.45e-28 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs597539 0.652 rs559032 chr11:68710847 G/T cg06112835 chr11:68658793 MRPL21 0.43 6.86 0.35 3.48e-11 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs4689388 0.890 rs11732208 chr4:6292716 G/C cg25554036 chr4:6271136 WFS1 0.54 8.78 0.44 9.02e-17 Type 2 diabetes and other traits;Type 2 diabetes; CRC cis rs875971 0.862 rs10274883 chr7:66116091 C/T cg18252515 chr7:66147081 NA 0.44 6.2 0.32 1.72e-9 Aortic root size; CRC cis rs10479542 0.784 rs6896940 chr5:178985994 G/C cg09060608 chr5:178986726 RUFY1 0.55 9.84 0.48 3.27e-20 Lung cancer; CRC cis rs796364 0.951 rs12620298 chr2:201047184 C/T cg25936922 chr2:200820526 C2orf60;C2orf47 -0.63 -6.73 -0.35 7.56e-11 Schizophrenia; CRC cis rs9389248 0.690 rs6939543 chr6:135255143 A/G cg22676075 chr6:135203613 NA -0.64 -9.98 -0.48 1.12e-20 High light scatter reticulocyte percentage of red cells; CRC cis rs7847628 0.587 rs4837796 chr9:123610288 A/G cg09419670 chr9:123605666 PSMD5;LOC253039 -0.97 -21.04 -0.76 7.01e-63 Birth weight; CRC cis rs4969178 1.000 rs7212201 chr17:76393896 C/A cg05887092 chr17:76393375 PGS1 0.56 10.33 0.5 7.26e-22 HDL cholesterol levels; CRC cis rs4819052 0.765 rs2838827 chr21:46656146 C/T cg11663144 chr21:46675770 NA -0.81 -13.4 -0.59 5.66e-33 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs1799949 0.965 rs4793233 chr17:41435437 G/C cg23758822 chr17:41437982 NA 0.8 13.49 0.6 2.61e-33 Menopause (age at onset); CRC cis rs9487051 0.837 rs932223 chr6:109586656 A/G cg21918786 chr6:109611834 NA -0.41 -7.43 -0.38 9.59e-13 Reticulocyte fraction of red cells; CRC cis rs2204008 0.683 rs12370288 chr12:38127740 G/A cg26384229 chr12:38710491 ALG10B 0.7 9.32 0.46 1.79e-18 Bladder cancer; CRC cis rs4919694 1.000 rs77318450 chr10:104733098 A/G cg04362960 chr10:104952993 NT5C2 1.24 10.84 0.51 1.26e-23 Arsenic metabolism; CRC trans rs9467711 0.720 rs35627490 chr6:26462104 C/T cg06606381 chr12:133084897 FBRSL1 -1.1 -7.57 -0.39 3.74e-13 Autism spectrum disorder or schizophrenia; CRC cis rs7202877 0.706 rs247434 chr16:75445304 G/A cg03315344 chr16:75512273 CHST6 -0.51 -5.9 -0.31 9.27e-9 Type 2 diabetes;Type 1 diabetes; CRC cis rs8141529 0.732 rs2269577 chr22:29196757 G/C cg02153584 chr22:29168773 CCDC117 0.53 8.02 0.4 1.81e-14 Lymphocyte counts; CRC cis rs11758351 0.660 rs113205297 chr6:26210808 A/C cg08260959 chr6:26240920 HIST1H4F -0.37 -6.03 -0.32 4.35e-9 Gout;Renal underexcretion gout; CRC cis rs172166 0.694 rs203876 chr6:28046673 T/C cg20615401 chr6:28092323 ZSCAN16 0.46 6.09 0.32 3.24e-9 Cardiac Troponin-T levels; CRC cis rs1552244 0.882 rs9312044 chr3:10037481 T/C cg02579736 chr3:10068473 FANCD2;CIDECP 0.86 11.45 0.53 8.88e-26 Alzheimer's disease; CRC cis rs56104184 0.725 rs1466896 chr19:49385253 C/G cg21252483 chr19:49399788 TULP2 -0.42 -6.3 -0.33 9.8e-10 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; CRC cis rs3812762 0.871 rs3862352 chr11:8818020 C/T cg00186954 chr11:8933980 ST5;C11orf17 -0.4 -6.38 -0.33 6.03e-10 Hypospadias; CRC cis rs864537 0.676 rs1773560 chr1:167421763 A/G cg09179987 chr1:167433047 CD247 0.47 7.45 0.38 8.41e-13 Celiac disease or Rheumatoid arthritis;Celiac disease; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg14014525 chr17:42148052 G6PC3 0.49 6.28 0.33 1.05e-9 Thyroid stimulating hormone; CRC cis rs501120 0.636 rs3123689 chr10:44773121 G/A cg09554077 chr10:44749378 NA 0.78 11.91 0.55 1.96e-27 Coronary artery disease;Coronary heart disease; CRC cis rs10504229 0.639 rs67996345 chr8:58117127 A/G cg24829409 chr8:58192753 C8orf71 -0.55 -8.03 -0.4 1.71e-14 Developmental language disorder (linguistic errors); CRC cis rs9911578 0.835 rs58647683 chr17:56483194 T/C cg05425664 chr17:57184151 TRIM37 0.44 6.7 0.35 9.02e-11 Intelligence (multi-trait analysis); CRC cis rs72781680 0.898 rs72796154 chr2:23933839 G/A cg08917208 chr2:24149416 ATAD2B 0.97 8.98 0.44 2.1e-17 Lymphocyte counts; CRC trans rs2303319 0.504 rs62189054 chr2:162624654 C/G cg22988483 chr14:93581567 ITPK1 -0.66 -6.08 -0.32 3.32e-9 Cognitive function; CRC cis rs9915657 0.660 rs2241170 chr17:70070989 G/C cg09344028 chr17:70110421 NA 0.49 7.33 0.37 1.75e-12 Thyroid hormone levels; CRC cis rs3820068 0.603 rs72647128 chr1:15963908 T/C cg27534772 chr1:16042836 PLEKHM2 0.55 10.93 0.52 6.22e-24 Systolic blood pressure; CRC cis rs1865760 0.713 rs6928951 chr6:25995554 C/T cg17691542 chr6:26056736 HIST1H1C 0.54 8.39 0.42 1.45e-15 Height; CRC cis rs2032447 0.714 rs129129 chr6:25961029 A/G cg26028573 chr6:26043587 HIST1H2BB 0.43 6.48 0.34 3.28e-10 Intelligence (multi-trait analysis); CRC cis rs11677370 0.603 rs1454242 chr2:3848532 G/A cg17052675 chr2:3827356 NA -0.65 -10.66 -0.51 5.47e-23 Type 2 diabetes; CRC cis rs9283706 0.594 rs7735834 chr5:66337444 A/G cg11590213 chr5:66331682 MAST4 -0.41 -5.84 -0.31 1.28e-8 Coronary artery disease; CRC cis rs9905704 0.918 rs11650343 chr17:56919549 G/A cg12560992 chr17:57184187 TRIM37 0.53 7.27 0.37 2.57e-12 Testicular germ cell tumor; CRC cis rs9527 0.551 rs28606370 chr10:104670832 C/A cg15744005 chr10:104629667 AS3MT -0.38 -7.78 -0.39 9.62e-14 Arsenic metabolism; CRC trans rs11088226 0.681 rs11700671 chr21:33938621 T/A cg09050820 chr6:167586206 TCP10L2 0.81 8.55 0.43 4.61e-16 Gastritis; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg07788451 chr12:58146524 CDK4 0.48 6.27 0.33 1.13e-9 Thyroid stimulating hormone; CRC cis rs4148883 0.689 rs1800760 chr4:100065626 A/T cg12011299 chr4:100065546 ADH4 0.52 11.47 0.53 7.56e-26 Alcohol dependence; CRC cis rs6502050 0.835 rs8065565 chr17:80115399 A/G cg25804541 chr17:80189381 SLC16A3 -0.3 -5.88 -0.31 9.83e-9 Life satisfaction; CRC cis rs13191362 1.000 rs13209728 chr6:162997533 A/C cg23758597 chr6:163146217 PARK2 -0.51 -5.91 -0.31 8.56e-9 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs524281 0.861 rs9645684 chr11:65907964 G/A cg16950941 chr11:66035639 RAB1B -0.61 -7.5 -0.38 5.99e-13 Electroencephalogram traits; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg01410469 chr8:82692895 NA 0.5 6.37 0.33 6.4e-10 Thyroid stimulating hormone; CRC cis rs1020064 0.945 rs1030878 chr2:105910598 T/G cg02079111 chr2:105885981 TGFBRAP1 0.5 7.08 0.36 9.03e-12 AIDS; CRC cis rs870825 0.549 rs28542773 chr4:185617935 A/G cg04058563 chr4:185651563 MLF1IP 0.72 9.38 0.46 1.12e-18 Blood protein levels; CRC cis rs992157 0.764 rs2015863 chr2:219185161 C/T cg00012203 chr2:219082015 ARPC2 -0.43 -6.05 -0.32 3.9e-9 Colorectal cancer; CRC cis rs4803468 1.000 rs878083 chr19:41897688 G/A cg09537434 chr19:41945824 ATP5SL -0.92 -18.05 -0.71 4.24e-51 Height; CRC cis rs6541297 1.000 rs6686054 chr1:230282853 C/T cg05784532 chr1:230284198 GALNT2 0.42 5.86 0.31 1.15e-8 Coronary artery disease; CRC trans rs11343 0.675 rs7359333 chr16:19262344 A/T cg03534058 chr9:99381359 CDC14B -0.46 -6.1 -0.32 2.95e-9 Parkinson's disease; CRC cis rs2070488 1.000 rs7373805 chr3:38455439 C/T cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.9 16.19 0.67 9.15e-44 Electrocardiographic conduction measures; CRC trans rs62295889 0.602 rs62295919 chr4:12537080 G/A cg03490839 chr16:73082051 ZFHX3 0.58 6.06 0.32 3.82e-9 Obesity-related traits; CRC cis rs593982 0.843 rs552312 chr11:65477349 C/T cg08755490 chr11:65554678 OVOL1 0.93 10.03 0.48 7.54e-21 Atopic dermatitis; CRC trans rs3942852 0.806 rs10769317 chr11:48150712 T/C cg03929089 chr4:120376271 NA -0.56 -7.15 -0.37 5.78e-12 Acute lymphoblastic leukemia (childhood); CRC cis rs2836633 0.894 rs55955614 chr21:40037330 T/G cg05519781 chr21:40033154 ERG 0.69 13.77 0.6 2.19e-34 Coronary artery disease; CRC cis rs17270561 0.609 rs7450798 chr6:25719280 T/A cg17691542 chr6:26056736 HIST1H1C 0.64 8.17 0.41 6.93e-15 Iron status biomarkers; CRC cis rs6547741 0.844 rs55826602 chr2:27863452 A/G cg22903471 chr2:27725779 GCKR -0.34 -5.63 -0.3 3.91e-8 Oral cavity cancer; CRC cis rs72781680 0.898 rs7569424 chr2:24036222 A/G cg08917208 chr2:24149416 ATAD2B 0.9 9.13 0.45 6.96e-18 Lymphocyte counts; CRC cis rs185694 1.000 rs202098 chr13:30896774 G/T cg07600127 chr13:30881527 KATNAL1 -0.57 -6.14 -0.32 2.38e-9 Antineutrophil cytoplasmic antibody-associated vasculitis; CRC cis rs7412746 0.658 rs11204723 chr1:150731618 T/C cg18016565 chr1:150552671 MCL1 0.44 6.06 0.32 3.76e-9 Melanoma; CRC cis rs9549367 0.713 rs56002882 chr13:113830694 T/C cg00898013 chr13:113819073 PROZ -0.58 -8.22 -0.41 4.71e-15 Platelet distribution width; CRC cis rs7677751 0.747 rs1800809 chr4:55093914 A/G cg00691999 chr4:55094011 PDGFRA 0.42 5.98 0.31 5.66e-9 Corneal astigmatism; CRC cis rs9463078 0.739 rs1041333 chr6:44945206 A/T cg25276700 chr6:44698697 NA -0.29 -7.14 -0.37 6.17e-12 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; CRC cis rs4074493 1.000 rs4074493 chr1:231172281 C/T cg22172038 chr1:231176991 FAM89A 0.35 6.11 0.32 2.88e-9 Carotid plaque burden (smoking interaction); CRC cis rs7927771 0.756 rs10742803 chr11:47439938 A/G cg20135002 chr11:47629003 NA 0.34 5.72 0.3 2.37e-8 Subjective well-being; CRC trans rs3743266 0.613 rs2414669 chr15:60708824 A/G cg25483003 chr9:139948856 ENTPD2 0.31 6.07 0.32 3.61e-9 Menarche (age at onset); CRC cis rs2295359 1.000 rs4655684 chr1:67611772 A/G cg03340356 chr1:67600835 NA -0.25 -5.88 -0.31 1e-8 Psoriasis; CRC cis rs853679 0.517 rs9368554 chr6:28082711 T/C cg12172441 chr6:28176163 NA 0.62 7.27 0.37 2.56e-12 Depression; CRC cis rs25645 0.502 rs8065126 chr17:38099035 C/T cg24910161 chr17:38119198 GSDMA 0.35 5.72 0.3 2.44e-8 Myeloid white cell count; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg00287370 chr1:234736092 NA 0.41 6.45 0.34 3.89e-10 Intelligence (multi-trait analysis); CRC cis rs9462846 0.691 rs9462853 chr6:42910666 T/C cg10862848 chr6:42927986 GNMT -0.29 -6.05 -0.32 3.92e-9 Blood protein levels; CRC trans rs2727020 0.576 rs1917321 chr11:49377760 A/C cg03929089 chr4:120376271 NA -0.65 -10.1 -0.49 4.44e-21 Coronary artery disease; CRC cis rs6582630 0.615 rs3914894 chr12:38480280 C/T cg13010199 chr12:38710504 ALG10B -0.41 -5.92 -0.31 8.25e-9 Drug-induced liver injury (flucloxacillin); CRC cis rs4713118 0.621 rs4713133 chr6:28034041 T/C cg12963246 chr6:28129442 ZNF389 0.47 5.77 0.3 1.84e-8 Parkinson's disease; CRC cis rs6952808 0.609 rs10274300 chr7:1950405 C/G cg21782813 chr7:2030301 MAD1L1 0.4 7.39 0.38 1.23e-12 Bipolar disorder and schizophrenia; CRC trans rs875971 0.660 rs2191268 chr7:66110224 C/T cg12831148 chr6:146136093 FBXO30 -0.39 -6.01 -0.31 5.04e-9 Aortic root size; CRC cis rs2228479 0.702 rs2074903 chr16:89811663 T/C cg06558623 chr16:89946397 TCF25 1.15 10.8 0.51 1.85e-23 Skin colour saturation; CRC cis rs2952156 1.000 rs2934967 chr17:37870378 G/A cg11212589 chr17:38028394 ZPBP2 0.35 5.89 0.31 9.44e-9 Asthma; CRC cis rs1005277 0.579 rs1740732 chr10:38491385 C/T cg00409905 chr10:38381863 ZNF37A -0.63 -10.39 -0.5 4.67e-22 Extrinsic epigenetic age acceleration; CRC cis rs9916302 0.904 rs10432031 chr17:37397852 G/A cg15445000 chr17:37608096 MED1 0.39 8.36 0.42 1.74e-15 Glomerular filtration rate (creatinine); CRC cis rs7615952 0.576 rs4646763 chr3:125822129 G/A cg04553112 chr3:125709451 NA -0.53 -6.1 -0.32 3.02e-9 Blood pressure (smoking interaction); CRC cis rs2303745 0.589 rs7246262 chr19:17392483 C/G cg04248312 chr19:17393744 ANKLE1 -0.93 -14.26 -0.62 2.98e-36 Systemic lupus erythematosus; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg26187342 chr17:65713858 NOL11 0.41 6.52 0.34 2.66e-10 Liver disease severity in Alagille syndrome; CRC cis rs611744 0.529 rs13282825 chr8:109263237 T/C cg18478394 chr8:109455254 TTC35 0.38 5.82 0.31 1.41e-8 Dupuytren's disease; CRC cis rs8058578 0.945 rs885107 chr16:30672719 T/C cg02466173 chr16:30829666 NA -0.66 -9.77 -0.47 5.83e-20 Multiple myeloma; CRC cis rs6952808 0.929 rs4721217 chr7:1973579 C/T cg02951883 chr7:2050386 MAD1L1 -0.71 -10.67 -0.51 5.11e-23 Bipolar disorder and schizophrenia; CRC cis rs3771570 1.000 rs55634485 chr2:242268994 T/C cg21155796 chr2:242212141 HDLBP 0.64 6.97 0.36 1.72e-11 Prostate cancer; CRC cis rs2019137 0.936 rs2241978 chr2:113954006 A/G cg19083407 chr2:113993142 PAX8;LOC440839;LOC654433 -0.47 -6.56 -0.34 2.04e-10 Lymphocyte counts; CRC cis rs6743376 0.556 rs1530553 chr2:113818171 G/A cg09040174 chr2:113837401 NA 0.44 6.44 0.33 4.3e-10 Inflammatory biomarkers; CRC cis rs629535 0.911 rs490165 chr8:70014976 A/G cg26132723 chr8:70041827 NA -0.35 -5.95 -0.31 6.99e-9 Dupuytren's disease; CRC cis rs9322193 0.923 rs9322200 chr6:149951214 G/A cg13206674 chr6:150067644 NUP43 0.64 9.66 0.47 1.32e-19 Lung cancer; CRC cis rs12282928 1.000 rs7949513 chr11:48329713 T/C cg20307385 chr11:47447363 PSMC3 0.48 5.9 0.31 9.15e-9 Migraine - clinic-based; CRC cis rs10927875 0.691 rs1048302 chr1:16340879 T/G cg21385522 chr1:16154831 NA 0.62 7.8 0.4 8.04e-14 Dilated cardiomyopathy; CRC cis rs7762018 0.607 rs75521584 chr6:170051595 T/C cg19338460 chr6:170058176 WDR27 -1.22 -10.16 -0.49 2.95e-21 Thiazide-induced adverse metabolic effects in hypertensive patients; CRC cis rs10097731 0.901 rs10464890 chr8:82042727 A/G cg25230327 chr8:82042993 NA -0.92 -13.67 -0.6 5.31e-34 Serum total protein level; CRC cis rs17023223 0.537 rs12086549 chr1:119614337 A/T cg05756136 chr1:119680316 WARS2 0.52 6.95 0.36 1.98e-11 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for BMI in active individuals; CRC cis rs6076065 0.692 rs6083111 chr20:23374667 A/G cg11657817 chr20:23433608 CST11 0.44 6.63 0.34 1.41e-10 Facial morphology (factor 15, philtrum width); CRC cis rs6426558 0.537 rs2492630 chr1:227286931 A/G cg10327440 chr1:227177885 CDC42BPA 0.45 6.8 0.35 5.03e-11 Neutrophil percentage of white cells; CRC cis rs4819052 0.851 rs1056099 chr21:46678892 G/A cg11663144 chr21:46675770 NA -0.7 -11.31 -0.53 2.85e-25 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs7552404 0.590 rs1565717 chr1:76320441 T/C cg10523679 chr1:76189770 ACADM -0.68 -8.97 -0.44 2.29e-17 Blood metabolite levels;Acylcarnitine levels; CRC cis rs7843479 0.601 rs7220 chr8:21863290 G/A cg17168535 chr8:21777572 XPO7 0.59 9.66 0.47 1.32e-19 Mean corpuscular volume; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg06586915 chr7:65958596 NA 0.49 6.17 0.32 1.97e-9 Thyroid stimulating hormone; CRC cis rs4713118 0.662 rs149948 chr6:27974817 C/G cg03623178 chr6:28175578 NA 0.83 12.42 0.56 2.64e-29 Parkinson's disease; CRC cis rs10751667 0.643 rs7394524 chr11:933865 T/C ch.11.42038R chr11:967971 AP2A2 0.6 10.26 0.49 1.35e-21 Alzheimer's disease (late onset); CRC cis rs2976388 0.590 rs3736011 chr8:143817789 G/A cg05569086 chr8:143859399 LYNX1 -0.4 -6.51 -0.34 2.81e-10 Urinary tract infection frequency; CRC cis rs4363385 0.510 rs6689510 chr1:153048039 G/A cg25856811 chr1:152973957 SPRR3 -0.21 -5.69 -0.3 2.74e-8 Inflammatory skin disease; CRC cis rs6502050 0.777 rs4625783 chr17:80086395 T/C cg09264619 chr17:80180166 NA 0.36 6.07 0.32 3.45e-9 Life satisfaction; CRC cis rs7107174 1.000 rs729354 chr11:77962453 T/A cg02023728 chr11:77925099 USP35 0.48 7.51 0.38 5.64e-13 Testicular germ cell tumor; CRC cis rs10504229 0.683 rs11785260 chr8:58132906 A/G cg24829409 chr8:58192753 C8orf71 -0.55 -8.03 -0.4 1.71e-14 Developmental language disorder (linguistic errors); CRC cis rs9911578 1.000 rs304296 chr17:56834229 G/T cg12560992 chr17:57184187 TRIM37 0.91 16.74 0.68 5.96e-46 Intelligence (multi-trait analysis); CRC cis rs7918232 0.882 rs788237 chr10:27457932 C/T cg14442939 chr10:27389572 ANKRD26 -0.82 -9.05 -0.45 1.31e-17 Breast cancer; CRC cis rs13191362 1.000 rs35103567 chr6:163183400 G/A cg21926612 chr6:163149169 PACRG;PARK2 0.95 12.47 0.57 1.67e-29 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs554111 0.963 rs601329 chr1:21044161 A/G cg08890418 chr1:21044141 KIF17 0.33 5.98 0.31 5.89e-9 Facial morphology (factor 17, height of vermillion upper lip); CRC trans rs12599106 0.792 rs12597352 chr16:34638507 A/T cg07332563 chr6:291687 DUSP22 -0.48 -6.86 -0.35 3.46e-11 Menopause (age at onset); CRC cis rs9611565 0.559 rs9611619 chr22:41986714 C/T cg03806693 chr22:41940476 POLR3H -1.04 -11.6 -0.54 2.54e-26 Vitiligo; CRC cis rs4253772 0.530 rs6008774 chr22:46755298 C/G cg03482458 chr22:46692211 CN5H6.4;GTSE1 0.54 7.14 0.37 5.87e-12 LDL cholesterol;Cholesterol, total; CRC cis rs2153535 0.504 rs4493781 chr6:8473941 G/C cg07606381 chr6:8435919 SLC35B3 0.68 10.85 0.51 1.17e-23 Motion sickness; CRC cis rs12476592 0.571 rs166384 chr2:63863630 G/T cg10828910 chr2:63850056 LOC388955 0.49 6.04 0.32 4.23e-9 Childhood ear infection; CRC cis rs17270561 0.609 rs9358886 chr6:25758253 T/A cg17691542 chr6:26056736 HIST1H1C 0.74 9.37 0.46 1.23e-18 Iron status biomarkers; CRC trans rs7615952 0.546 rs2979306 chr3:125312130 C/A cg02007433 chr3:129722099 NA -0.52 -6.53 -0.34 2.44e-10 Blood pressure (smoking interaction); CRC cis rs2952156 0.920 rs732084 chr17:37834357 A/C cg11212589 chr17:38028394 ZPBP2 0.34 6.1 0.32 2.96e-9 Asthma; CRC cis rs7618915 0.571 rs33964154 chr3:52596914 A/G cg15147215 chr3:52552868 STAB1 -0.63 -10.52 -0.5 1.72e-22 Bipolar disorder; CRC cis rs1448094 0.511 rs61930037 chr12:86154503 G/A cg18827107 chr12:86230957 RASSF9 -0.41 -6.18 -0.32 1.89e-9 Major depressive disorder; CRC cis rs172166 0.516 rs1225715 chr6:28113373 C/T cg03623178 chr6:28175578 NA -0.61 -9.17 -0.45 5.2e-18 Cardiac Troponin-T levels; CRC cis rs2516839 0.517 rs1556257 chr1:161051134 A/G cg11161846 chr1:160990452 F11R -0.4 -6.01 -0.31 5.04e-9 Granulocyte percentage of myeloid white cells; CRC cis rs9381040 0.701 rs4711658 chr6:41162891 C/T cg04346459 chr6:41068666 NFYA;LOC221442 0.42 6.55 0.34 2.19e-10 Alzheimer's disease (late onset); CRC cis rs9469578 0.901 rs16869459 chr6:33714908 G/A cg18708504 chr6:33715942 IP6K3 0.65 7.39 0.38 1.25e-12 Phosphorus levels; CRC cis rs853679 0.517 rs56364346 chr6:28050762 T/G cg25164649 chr6:28176230 NA 0.73 9.18 0.45 4.85e-18 Depression; CRC cis rs9443189 0.570 rs775075 chr6:76380035 A/C cg01950844 chr6:76311363 SENP6 -0.74 -9.84 -0.48 3.35e-20 Prostate cancer; CRC cis rs13031619 0.650 rs6542617 chr2:3694932 C/T cg19052272 chr2:3704530 ALLC 0.47 6.48 0.34 3.41e-10 Response to inhaled corticosteroid treatment in asthma (change in FEV1); CRC cis rs2949837 0.581 rs2965074 chr7:45983129 G/T cg15898840 chr7:45960834 IGFBP3 0.46 7.68 0.39 1.8e-13 Sitting height ratio; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg14080001 chr15:75940555 SNX33 0.41 6.09 0.32 3.13e-9 Response to antipsychotic treatment; CRC cis rs1799949 0.965 rs4793204 chr17:41279298 A/G cg23758822 chr17:41437982 NA 0.79 13.46 0.6 3.47e-33 Menopause (age at onset); CRC cis rs11148252 0.819 rs7336679 chr13:53043333 G/A cg00495681 chr13:53174319 NA 0.58 8.64 0.43 2.5e-16 Lewy body disease; CRC cis rs9287719 0.810 rs7601748 chr2:10785446 A/G cg00105475 chr2:10696890 NA 0.43 6.83 0.35 4.05e-11 Prostate cancer; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg00331096 chr20:22564947 FOXA2 0.48 6.97 0.36 1.75e-11 Response to antipsychotic treatment; CRC cis rs13108904 0.935 rs13148614 chr4:1248357 G/C cg16405210 chr4:1374714 KIAA1530 -0.48 -6.88 -0.35 3.08e-11 Obesity-related traits; CRC cis rs7113874 0.524 rs10769921 chr11:8621143 G/A cg02811074 chr11:8615871 STK33 0.33 5.88 0.31 9.85e-9 Body mass index in physically active individuals;Body mass index (joint analysis main effects and physical activity interaction); CRC trans rs7474896 0.537 rs2749588 chr10:38269457 C/G cg05175333 chr18:18692284 ROCK1 0.47 6.06 0.32 3.77e-9 Obesity (extreme); CRC cis rs9487051 0.735 rs455839 chr6:109524221 G/A cg21918786 chr6:109611834 NA -0.33 -5.61 -0.3 4.38e-8 Reticulocyte fraction of red cells; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg22152050 chr18:60987904 BCL2 0.41 6.97 0.36 1.76e-11 Liver disease severity in Alagille syndrome; CRC cis rs9549260 0.785 rs10507484 chr13:41218134 T/C cg21288729 chr13:41239152 FOXO1 0.49 7.69 0.39 1.67e-13 Red blood cell count; CRC cis rs3093024 0.935 rs10946216 chr6:167538897 T/C cg07741184 chr6:167504864 NA -0.4 -7.12 -0.37 6.85e-12 Rheumatoid arthritis; CRC cis rs709400 0.663 rs11628213 chr14:103952453 A/C cg12935359 chr14:103987150 CKB -0.53 -8.22 -0.41 4.75e-15 Body mass index; CRC cis rs6570726 0.791 rs435671 chr6:145881215 A/G cg23711669 chr6:146136114 FBXO30 0.77 13.41 0.59 5.08e-33 Lobe attachment (rater-scored or self-reported); CRC cis rs116248771 0.549 rs9825140 chr3:158435374 C/T cg16708174 chr3:158430962 RARRES1 0.45 6.05 0.32 4.04e-9 diarrhoeal disease at age 2; CRC cis rs9611565 0.659 rs4822036 chr22:41936019 A/G cg03806693 chr22:41940476 POLR3H -1.11 -14.99 -0.64 4.38e-39 Vitiligo; CRC cis rs9486715 0.867 rs9384585 chr6:96875664 C/T cg18709589 chr6:96969512 KIAA0776 0.47 7.01 0.36 1.34e-11 Headache; CRC cis rs875971 0.895 rs4718349 chr7:65909011 C/G cg00343986 chr7:65444356 GUSB 0.43 6.29 0.33 1.03e-9 Aortic root size; CRC trans rs2840044 1.000 rs225304 chr17:33921857 G/T cg19694781 chr19:47549865 TMEM160 -0.44 -7.01 -0.36 1.36e-11 Response to radiotherapy in cancer (late toxicity); CRC cis rs4713118 0.662 rs149947 chr6:27972433 A/T cg03623178 chr6:28175578 NA 0.87 12.9 0.58 4.23e-31 Parkinson's disease; CRC cis rs9325144 0.555 rs7960411 chr12:38703019 A/G cg13010199 chr12:38710504 ALG10B -0.43 -6.18 -0.32 1.88e-9 Morning vs. evening chronotype; CRC trans rs61931739 0.500 rs11053198 chr12:34444013 G/C cg26384229 chr12:38710491 ALG10B 0.62 9.11 0.45 8.27e-18 Morning vs. evening chronotype; CRC cis rs6685188 0.920 rs10751444 chr1:205662144 A/G cg14893161 chr1:205819251 PM20D1 -0.44 -6.24 -0.33 1.35e-9 White blood cell count (basophil);Basophil percentage of white cells; CRC cis rs7772486 0.720 rs6931553 chr6:146112348 T/C cg23711669 chr6:146136114 FBXO30 -0.77 -13.39 -0.59 6.18e-33 Lobe attachment (rater-scored or self-reported); CRC cis rs7666738 0.512 rs6532704 chr4:98777562 C/T cg05340658 chr4:99064831 C4orf37 0.47 6.96 0.36 1.84e-11 Colonoscopy-negative controls vs population controls; CRC cis rs6951245 0.872 rs11768486 chr7:1101290 C/A cg20603222 chr7:1096387 C7orf50;GPR146 -0.72 -8.66 -0.43 2.19e-16 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs274567 0.602 rs272853 chr5:131688561 A/G cg20512303 chr5:131592959 PDLIM4 0.38 6.71 0.35 8.6e-11 Blood metabolite levels; CRC trans rs7395662 0.819 rs1473579 chr11:48901553 A/G cg21153622 chr11:89784906 NA -0.48 -7.6 -0.39 3.06e-13 HDL cholesterol; CRC cis rs6539267 0.741 rs2279759 chr12:106694988 T/C cg00173435 chr12:106696525 TCP11L2 0.54 7.25 0.37 3.03e-12 Tourette syndrome; CRC cis rs769267 1.000 rs1009136 chr19:19440428 A/G cg20644253 chr19:19431407 KIAA0892;SF4 -0.41 -5.71 -0.3 2.55e-8 Tonsillectomy; CRC trans rs2303319 0.504 rs1006427 chr2:162592328 T/C cg27342122 chr8:133787442 PHF20L1 -0.72 -6.12 -0.32 2.68e-9 Cognitive function; CRC cis rs11190604 0.767 rs11190533 chr10:102190792 T/C cg07080220 chr10:102295463 HIF1AN 0.5 6.35 0.33 7.2e-10 Palmitoleic acid (16:1n-7) levels; CRC cis rs3820068 0.603 rs6695903 chr1:15985940 C/T cg27534772 chr1:16042836 PLEKHM2 0.5 9.67 0.47 1.21e-19 Systolic blood pressure; CRC cis rs2732480 0.500 rs12828309 chr12:48641160 C/T cg04545296 chr12:48745243 ZNF641 0.32 5.61 0.3 4.4e-8 Hemoglobin concentration;Red blood cell count;Hematocrit; CRC cis rs2797160 0.967 rs2226158 chr6:125995467 C/T cg05901451 chr6:126070800 HEY2 -0.44 -6.85 -0.35 3.63e-11 Endometrial cancer; CRC cis rs1707322 1.000 rs7519181 chr1:46387829 G/C cg06784218 chr1:46089804 CCDC17 0.51 8.98 0.44 2.07e-17 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs6429082 0.818 rs696248 chr1:235668511 C/A cg26050004 chr1:235667680 B3GALNT2 0.57 7.66 0.39 2.11e-13 Adiposity; CRC cis rs763121 0.744 rs5757140 chr22:38957013 T/C cg06544989 chr22:39130855 UNC84B 0.42 6.15 0.32 2.24e-9 Menopause (age at onset); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg15044954 chr7:89874365 C7orf63 0.5 7.45 0.38 8.1e-13 Response to antipsychotic treatment; CRC cis rs4665809 0.590 rs7582341 chr2:26416301 A/G cg27170947 chr2:26402098 FAM59B -0.59 -7.62 -0.39 2.79e-13 Gut microbiome composition (summer); CRC cis rs11098499 0.754 rs11732087 chr4:120239831 A/G cg09307838 chr4:120376055 NA 0.62 9.75 0.47 6.92e-20 Corneal astigmatism; CRC cis rs9811920 0.609 rs704583 chr3:99643693 A/G cg07805332 chr3:99536008 MIR548G;C3orf26 -0.51 -7.68 -0.39 1.84e-13 Axial length; CRC cis rs6762 0.642 rs28692469 chr11:839675 T/C cg16425592 chr11:842748 TSPAN4;POLR2L -0.56 -8.23 -0.41 4.32e-15 Mean platelet volume; CRC cis rs9469578 1.000 rs9469581 chr6:33715904 C/A cg18708504 chr6:33715942 IP6K3 0.65 7.5 0.38 5.93e-13 Phosphorus levels; CRC cis rs6951245 0.529 rs76001997 chr7:1152615 C/T cg18402987 chr7:1209562 NA 0.55 6.71 0.35 8.4e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs172166 0.694 rs1631552 chr6:28089699 C/A cg12273811 chr6:28175739 NA 0.61 8.97 0.44 2.27e-17 Cardiac Troponin-T levels; CRC cis rs950169 0.526 rs698620 chr15:85177208 G/A cg12501888 chr15:85177176 SCAND2 -0.48 -8.2 -0.41 5.43e-15 Schizophrenia; CRC cis rs17001868 0.568 rs9611316 chr22:40737027 A/G cg07138101 chr22:40742427 ADSL 0.59 7.84 0.4 6.24e-14 Mammographic density (dense area); CRC cis rs7618915 0.524 rs12488461 chr3:52698417 T/C cg15147215 chr3:52552868 STAB1 -0.62 -10.31 -0.49 8.76e-22 Bipolar disorder; CRC cis rs9611565 0.694 rs79011 chr22:41866938 A/G cg06634786 chr22:41940651 POLR3H 0.59 7.18 0.37 4.59e-12 Vitiligo; CRC cis rs9329221 0.905 rs17765901 chr8:10249480 G/T cg27411982 chr8:10470053 RP1L1 -0.36 -5.87 -0.31 1.05e-8 Neuroticism; CRC cis rs10504229 0.775 rs55825382 chr8:58157605 G/A cg24829409 chr8:58192753 C8orf71 -0.59 -7.95 -0.4 3.01e-14 Developmental language disorder (linguistic errors); CRC cis rs10791323 0.569 rs11223609 chr11:133741766 C/T cg15485101 chr11:133734466 NA 0.43 8.1 0.41 1.06e-14 Childhood ear infection; CRC cis rs1838105 0.640 rs12603447 chr17:45146237 A/G cg16759221 chr17:45003025 GOSR2 -0.6 -9.23 -0.45 3.32e-18 Nonsyndromic cleft lip with cleft palate; CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg05808815 chr1:54666250 CYB5RL;MRPL37 0.39 6.3 0.33 9.52e-10 Obesity-related traits; CRC cis rs1801251 1.000 rs13008942 chr2:233594875 G/A cg25237894 chr2:233734115 C2orf82 0.54 8.77 0.44 9.91e-17 Coronary artery disease; CRC cis rs16867321 0.694 rs721301 chr2:181387265 A/G cg23363182 chr2:181467187 NA 0.55 8.0 0.4 2.15e-14 Obesity; CRC cis rs7300001 0.667 rs7302441 chr12:110506468 T/C cg12870014 chr12:110450643 ANKRD13A 0.94 9.82 0.48 3.97e-20 Headache; CRC cis rs7534824 0.625 rs61780281 chr1:101324152 A/G cg16556008 chr1:101360663 SLC30A7;EXTL2 0.59 5.61 0.3 4.38e-8 Refractive astigmatism; CRC cis rs9487051 0.768 rs458740 chr6:109525527 C/T cg01475377 chr6:109611718 NA -0.34 -5.98 -0.31 5.7e-9 Reticulocyte fraction of red cells; CRC cis rs2072499 0.966 rs1137703 chr1:156184458 T/C cg06970220 chr1:156163860 SLC25A44 0.52 7.56 0.38 4.01e-13 Testicular germ cell tumor; CRC cis rs2885135 1.000 rs12066711 chr1:13906820 C/T cg04886857 chr1:13914270 PDPN -0.36 -6.36 -0.33 6.72e-10 Response to cytadine analogues (cytosine arabinoside); CRC cis rs11229555 0.574 rs12272310 chr11:58186462 A/C cg15696309 chr11:58395628 NA -0.81 -10.31 -0.49 8.83e-22 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; CRC cis rs13118159 0.801 rs7664474 chr4:1329116 T/A cg16405210 chr4:1374714 KIAA1530 -0.43 -5.86 -0.31 1.13e-8 Longevity; CRC cis rs3106136 0.967 rs282449 chr4:95141228 G/A cg11021082 chr4:95130006 SMARCAD1 -0.46 -7.18 -0.37 4.6e-12 Capecitabine sensitivity; CRC trans rs12188164 0.686 rs72711367 chr5:418494 A/G cg15371732 chr17:78194151 SLC26A11;SGSH 0.45 6.28 0.33 1.09e-9 Cystic fibrosis severity; CRC cis rs1580019 0.961 rs766657 chr7:32499510 A/G cg06627557 chr7:32535165 LSM5;AVL9 0.73 11.39 0.53 1.42e-25 Cognitive ability; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg00736819 chr19:3871003 NA 0.37 6.13 0.32 2.51e-9 Liver disease severity in Alagille syndrome; CRC cis rs4665809 0.877 rs34536218 chr2:26287376 T/A cg26119090 chr2:26468346 HADHA;HADHB 0.63 7.14 0.37 5.9e-12 Gut microbiome composition (summer); CRC cis rs79349575 0.783 rs59270107 chr17:47026185 A/T cg22482690 chr17:47019901 SNF8 0.5 8.26 0.41 3.58e-15 Type 2 diabetes; CRC cis rs4689388 0.926 rs10012946 chr4:6293350 C/T cg25554036 chr4:6271136 WFS1 -0.57 -8.94 -0.44 2.92e-17 Type 2 diabetes and other traits;Type 2 diabetes; CRC cis rs12024301 0.557 rs114460405 chr1:183653703 G/A cg11505048 chr1:183622726 RGL1;APOBEC4 0.71 6.24 0.33 1.33e-9 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs9435341 0.965 rs55909997 chr1:107581039 G/A cg14671364 chr1:107599128 PRMT6 0.6 8.05 0.41 1.49e-14 Facial morphology (factor 21, depth of nasal alae); CRC cis rs7927592 0.956 rs2510384 chr11:68391837 C/A cg01657329 chr11:68192670 LRP5 -0.44 -6.11 -0.32 2.89e-9 Total body bone mineral density; CRC cis rs561341 0.769 rs7217004 chr17:30178092 A/G cg19193384 chr17:30244184 NA 0.53 5.95 0.31 6.73e-9 Hip circumference adjusted for BMI; CRC cis rs1707322 0.963 rs1768815 chr1:46528603 G/A cg06784218 chr1:46089804 CCDC17 -0.54 -9.36 -0.46 1.25e-18 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs9303280 0.901 rs7216389 chr17:38069949 C/T cg20243544 chr17:37824526 PNMT -0.43 -6.67 -0.35 1.09e-10 Self-reported allergy; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg24861683 chr3:37284451 GOLGA4 0.37 5.99 0.31 5.59e-9 Liver disease severity in Alagille syndrome; CRC cis rs10504229 0.593 rs75047131 chr8:58001320 A/G cg22535103 chr8:58192502 C8orf71 -0.63 -6.84 -0.35 3.92e-11 Developmental language disorder (linguistic errors); CRC cis rs1862618 0.641 rs252893 chr5:56224714 T/C cg12311346 chr5:56204834 C5orf35 -0.66 -9.84 -0.48 3.35e-20 Initial pursuit acceleration; CRC cis rs2836974 0.932 rs56306759 chr21:40608106 G/A cg17971929 chr21:40555470 PSMG1 0.82 11.69 0.54 1.24e-26 Cognitive function; CRC cis rs6840360 1.000 rs6535810 chr4:152592953 C/T cg09659197 chr4:152720779 NA 0.52 11.23 0.53 5.49e-25 Intelligence (multi-trait analysis); CRC cis rs9435341 0.965 rs1762485 chr1:107625056 C/T cg09367891 chr1:107599246 PRMT6 -0.68 -10.16 -0.49 2.83e-21 Facial morphology (factor 21, depth of nasal alae); CRC cis rs9926296 0.712 rs2437957 chr16:89715648 G/A cg03605463 chr16:89740564 NA 0.58 8.85 0.44 5.32e-17 Vitiligo; CRC trans rs6762477 0.748 rs34877766 chr3:50234126 A/G cg21665057 chr3:196295764 WDR53;FBXO45 0.44 6.62 0.34 1.45e-10 Menarche (age at onset); CRC cis rs3091242 0.933 rs61775174 chr1:25787313 G/A cg27572855 chr1:25598939 RHD -0.37 -6.38 -0.33 6.13e-10 Erythrocyte sedimentation rate; CRC cis rs7584330 0.910 rs72620830 chr2:238396985 C/T cg16989719 chr2:238392110 NA -0.42 -7.65 -0.39 2.27e-13 Prostate cancer; CRC trans rs11098499 0.779 rs80242894 chr4:120375752 G/A cg25214090 chr10:38739885 LOC399744 0.65 10.41 0.5 3.84e-22 Corneal astigmatism; CRC cis rs79390637 1 rs79390637 chr11:47456867 C/A cg05585544 chr11:47624801 NA -0.4 -6.36 -0.33 6.58e-10 Intraocular pressure; CRC cis rs55665837 0.961 rs60622588 chr11:14456998 T/C cg19336497 chr11:14380999 RRAS2 -0.39 -6.64 -0.34 1.3100000000000001e-10 Vitamin D levels; CRC cis rs9916302 0.752 rs11078895 chr17:37401051 A/G cg15445000 chr17:37608096 MED1 0.32 5.68 0.3 2.96e-8 Glomerular filtration rate (creatinine); CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg10954261 chr6:11094075 LOC221710 0.47 6.35 0.33 7.02e-10 Anxiety disorder; CRC cis rs72634258 0.842 rs6577463 chr1:8169485 T/G cg00042356 chr1:8021962 PARK7 -0.56 -6.3 -0.33 9.64e-10 Inflammatory bowel disease; CRC trans rs7618501 0.572 rs4688756 chr3:50040194 T/A cg21582582 chr3:182698605 DCUN1D1 0.42 6.12 0.32 2.73e-9 Intelligence (multi-trait analysis); CRC cis rs4141404 0.818 rs6518737 chr22:31582662 A/G cg22777020 chr22:31556080 RNF185 -0.45 -5.9 -0.31 8.94e-9 Paclitaxel-induced neuropathy; CRC cis rs3733585 0.699 rs6449172 chr4:9966036 A/T cg00071950 chr4:10020882 SLC2A9 -0.54 -9.68 -0.47 1.13e-19 Cleft plate (environmental tobacco smoke interaction); CRC cis rs477895 0.653 rs34113693 chr11:63900123 G/T cg19465662 chr11:63993652 NUDT22;TRPT1 0.73 8.97 0.44 2.22e-17 Mean platelet volume; CRC cis rs908922 0.676 rs2181172 chr1:152491794 A/G cg09873164 chr1:152488093 CRCT1 0.37 6.26 0.33 1.18e-9 Hair morphology; CRC cis rs6911131 0.554 rs11155304 chr6:143903156 A/G cg25407410 chr6:143891975 LOC285740 0.7 5.77 0.3 1.82e-8 Response to paliperidone in schizophrenia (positive Marder score); CRC cis rs889398 0.641 rs9936723 chr16:69884854 G/A cg00738113 chr16:70207722 CLEC18C -0.37 -6.46 -0.34 3.69e-10 Body mass index; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg21201435 chr9:108210605 FSD1L 0.4 6.18 0.32 1.86e-9 Response to antipsychotic treatment; CRC cis rs6831352 0.918 rs13143133 chr4:100054970 A/G cg13256891 chr4:100009986 ADH5 -0.66 -8.89 -0.44 4.04e-17 Alcohol dependence; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg00040446 chr1:40367965 MYCL1 0.39 6.22 0.32 1.52e-9 Liver disease severity in Alagille syndrome; CRC cis rs4466137 0.830 rs6886442 chr5:82973210 A/C cg16102102 chr5:83017553 HAPLN1 0.43 6.55 0.34 2.18e-10 Prostate cancer; CRC cis rs1127311 0.905 rs6699729 chr1:154582896 A/T cg17218026 chr1:154582156 ADAR 0.69 12.32 0.56 5.96e-29 C-reactive protein levels or triglyceride levels (pleiotropy); CRC cis rs9733 0.596 rs1336898 chr1:150665050 G/A cg10589385 chr1:150898437 SETDB1 0.28 5.98 0.31 5.86e-9 Tonsillectomy; CRC cis rs2073300 0.609 rs6137910 chr20:23346515 C/G cg12062639 chr20:23401060 NAPB 0.75 6.76 0.35 6.32e-11 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs7312933 0.703 rs10459290 chr12:42613290 T/G cg11827402 chr12:42719852 PPHLN1;ZCRB1 0.63 8.87 0.44 4.8e-17 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CRC cis rs9311474 0.607 rs28661185 chr3:52567188 G/T cg11645453 chr3:52864694 ITIH4 0.33 5.9 0.31 9.04e-9 Electroencephalogram traits; CRC cis rs11098499 0.697 rs6832410 chr4:120296800 A/G cg09307838 chr4:120376055 NA 0.71 10.93 0.52 6.41e-24 Corneal astigmatism; CRC cis rs11758351 1.000 rs112751982 chr6:26191958 C/T cg22723502 chr6:26240528 HIST1H4F -0.38 -5.83 -0.31 1.35e-8 Gout;Renal underexcretion gout; CRC trans rs57221529 0.766 rs12522140 chr5:587261 C/A cg25482853 chr8:67687455 SGK3 1.24 14.83 0.63 1.93e-38 Lung disease severity in cystic fibrosis; CRC cis rs9372498 0.536 rs9320656 chr6:118894468 A/G cg18833306 chr6:118973337 C6orf204 -0.44 -5.89 -0.31 9.35e-9 Diastolic blood pressure; CRC cis rs897984 0.645 rs58726213 chr16:31044683 A/G cg02466173 chr16:30829666 NA -0.65 -9.91 -0.48 1.91e-20 Dementia with Lewy bodies; CRC cis rs10155981 0.510 rs75613086 chr7:22584526 A/C cg05062323 chr7:22590069 NA -0.61 -5.72 -0.3 2.42e-8 Bilirubin levels; CRC cis rs977987 0.835 rs1010630 chr16:75328591 G/T cg03315344 chr16:75512273 CHST6 0.51 8.76 0.44 1.02e-16 Dupuytren's disease; CRC cis rs2228479 0.867 rs62052185 chr16:89969254 C/T cg06558623 chr16:89946397 TCF25 1.07 11.48 0.53 7.25e-26 Skin colour saturation; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg22249281 chr19:41082756 SHKBP1 0.41 5.99 0.31 5.49e-9 Intelligence (multi-trait analysis); CRC cis rs4499344 0.730 rs259285 chr19:33164697 T/C cg08127369 chr19:33164662 ANKRD27 0.39 6.01 0.31 5.02e-9 Mean platelet volume; CRC cis rs1044826 0.642 rs9859864 chr3:139091219 G/T cg15131784 chr3:139108705 COPB2 -0.42 -6.04 -0.32 4.28e-9 Obesity-related traits; CRC cis rs875971 0.862 rs35034167 chr7:65580166 C/G cg18252515 chr7:66147081 NA 0.39 5.74 0.3 2.14e-8 Aortic root size; CRC cis rs1552244 0.510 rs13075308 chr3:10034925 G/C cg18598329 chr3:10140678 FANCD2;C3orf24 -0.81 -10.69 -0.51 4.35e-23 Alzheimer's disease; CRC cis rs2549003 1.000 rs10068129 chr5:131821246 A/G cg00255919 chr5:131827918 IRF1 -0.58 -11.58 -0.54 3.13e-26 Asthma (sex interaction); CRC cis rs7584330 0.554 rs10178682 chr2:238433818 T/G cg14458575 chr2:238380390 NA 0.53 7.01 0.36 1.36e-11 Prostate cancer; CRC cis rs4665809 0.590 rs7586047 chr2:26447335 A/G cg04944784 chr2:26401820 FAM59B -0.83 -10.74 -0.51 2.96e-23 Gut microbiome composition (summer); CRC cis rs10504229 0.683 rs55714371 chr8:58131846 T/G cg04204079 chr8:58130323 NA -0.45 -5.78 -0.3 1.71e-8 Developmental language disorder (linguistic errors); CRC cis rs3812049 0.532 rs251390 chr5:127538346 G/A cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.66 8.02 0.4 1.92e-14 Lymphocyte counts;Red cell distribution width; CRC cis rs921968 0.541 rs593888 chr2:219427597 A/G cg02176678 chr2:219576539 TTLL4 0.53 8.47 0.42 8.56e-16 Mean corpuscular hemoglobin concentration; CRC cis rs4819052 0.851 rs35871601 chr21:46675214 C/T cg11663144 chr21:46675770 NA -0.86 -14.97 -0.64 5.18e-39 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs939658 0.875 rs2177057 chr15:79441441 G/C cg17916960 chr15:79447300 NA -0.44 -7.1 -0.36 7.68e-12 Refractive error; CRC trans rs9929218 0.508 rs6499194 chr16:68744100 T/C cg04657470 chr2:198365150 HSPE1;HSPD1 1.04 20.51 0.75 8.58e-61 Colorectal cancer; CRC cis rs28655083 0.529 rs682081 chr16:77103050 T/C cg01753188 chr16:77233325 SYCE1L;MON1B 0.48 6.89 0.36 2.84e-11 Lobe attachment (rater-scored or self-reported); CRC cis rs6694672 0.867 rs6679189 chr1:197100556 C/A cg13682187 chr1:196946512 CFHR5 0.43 6.97 0.36 1.69e-11 Asthma; CRC cis rs13118159 0.509 rs1882098 chr4:1352431 T/C cg19318889 chr4:1322082 MAEA 0.7 10.43 0.5 3.53e-22 Longevity; CRC cis rs3924048 0.559 rs6541039 chr1:12626261 T/C cg00291366 chr1:12616550 NA 0.55 9.72 0.47 8.52e-20 Optic cup area; CRC cis rs7811142 1.000 rs7783550 chr7:99987805 A/G cg00814883 chr7:100076585 TSC22D4 0.73 9.51 0.46 4.07e-19 Platelet count; CRC trans rs66759488 0.739 rs10851451 chr15:47608991 A/G cg01583514 chr19:3730768 TJP3 -0.42 -6.03 -0.32 4.39e-9 Lung cancer; CRC cis rs311392 0.554 rs395449 chr8:55100391 A/G cg06042504 chr8:55087323 NA -0.37 -5.78 -0.3 1.71e-8 Pelvic organ prolapse (moderate/severe); CRC cis rs6461049 0.765 rs10224497 chr7:2149967 A/G cg04267008 chr7:1944627 MAD1L1 -0.48 -6.89 -0.36 2.77e-11 Schizophrenia; CRC cis rs2576037 0.501 rs7227700 chr18:44537102 T/G cg24750912 chr18:44543259 TCEB3CL;KATNAL2 0.32 6.27 0.33 1.14e-9 Personality dimensions; CRC trans rs1814175 0.817 rs7481230 chr11:49772235 G/A cg21153622 chr11:89784906 NA -0.38 -6.11 -0.32 2.75e-9 Height; CRC cis rs2288073 0.965 rs10173949 chr2:24410256 A/C cg06627628 chr2:24431161 ITSN2 -0.72 -9.69 -0.47 1.09e-19 Venous thromboembolism (SNP x SNP interaction); CRC cis rs7737355 0.947 rs4705894 chr5:131079288 A/G cg06307176 chr5:131281290 NA 0.4 5.92 0.31 8.21e-9 Life satisfaction; CRC trans rs12478296 0.581 rs4973645 chr2:242993577 T/C cg18288967 chr1:45987694 PRDX1 0.66 6.83 0.35 4.21e-11 Obesity-related traits; CRC cis rs2637266 0.519 rs7072009 chr10:78301652 G/A cg18941641 chr10:78392320 NA -0.36 -6.01 -0.31 4.86e-9 Pulmonary function; CRC trans rs1346081 0.786 rs1425645 chr4:68028175 C/T cg01664833 chr10:134351118 INPP5A 0.5 6.22 0.32 1.54e-9 Intelligence (multi-trait analysis); CRC trans rs747782 0.528 rs7937670 chr11:48313216 C/T cg02254774 chr11:50257496 LOC441601 0.57 6.03 0.32 4.33e-9 Intraocular pressure; CRC cis rs4332037 0.539 rs57148375 chr7:2025001 G/C cg21155852 chr7:2048760 MAD1L1 -0.53 -7.19 -0.37 4.38e-12 Bipolar disorder; CRC cis rs1799949 1.000 rs11653460 chr17:41331306 C/T cg23758822 chr17:41437982 NA 0.82 13.92 0.61 5.82e-35 Menopause (age at onset); CRC cis rs55665837 0.524 rs2882128 chr11:14414634 A/C cg19336497 chr11:14380999 RRAS2 -0.46 -7.92 -0.4 3.72e-14 Vitamin D levels; CRC cis rs1005277 0.579 rs2505248 chr10:38459097 A/G cg25427524 chr10:38739819 LOC399744 -0.76 -13.29 -0.59 1.46e-32 Extrinsic epigenetic age acceleration; CRC cis rs6840360 0.642 rs28666858 chr4:152416382 T/C cg09659197 chr4:152720779 NA 0.33 6.52 0.34 2.64e-10 Intelligence (multi-trait analysis); CRC cis rs2303745 0.589 rs1465576 chr19:17398487 G/A cg02221750 chr19:17393354 ANKLE1 -0.44 -6.61 -0.34 1.56e-10 Systemic lupus erythematosus; CRC cis rs3796619 1.000 rs1466215 chr4:1072220 C/T cg27284194 chr4:1044797 NA 0.42 6.42 0.33 4.85e-10 Recombination rate (males); CRC cis rs7660520 0.557 rs76004373 chr4:183731011 C/G cg12524338 chr4:183729343 NA 0.52 5.82 0.31 1.37e-8 Pediatric autoimmune diseases; CRC trans rs10077885 0.869 rs2974516 chr5:114448597 A/G cg05316309 chr22:43011028 POLDIP3;RNU12 0.37 6.03 0.32 4.4e-9 Diastolic blood pressure;Systolic blood pressure; CRC cis rs9911578 0.967 rs7222789 chr17:56819853 C/G cg12560992 chr17:57184187 TRIM37 0.9 16.62 0.68 1.87e-45 Intelligence (multi-trait analysis); CRC cis rs921968 0.565 rs35358516 chr2:219625723 A/C cg02176678 chr2:219576539 TTLL4 -0.39 -6.32 -0.33 8.67e-10 Mean corpuscular hemoglobin concentration; CRC cis rs3617 0.625 rs2240917 chr3:52851137 T/C cg18099408 chr3:52552593 STAB1 -0.35 -6.01 -0.31 4.81e-9 Red blood cell count;Autism spectrum disorder or schizophrenia; CRC cis rs910316 1.000 rs10138183 chr14:75615227 T/C cg08847533 chr14:75593920 NEK9 0.94 18.11 0.71 2.52e-51 Height; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg14634336 chr6:111804804 REV3L 0.57 7.7 0.39 1.5700000000000001e-13 Thyroid stimulating hormone; CRC cis rs9926296 0.572 rs2079671 chr16:89884981 T/C cg04287289 chr16:89883240 FANCA 0.6 9.68 0.47 1.17e-19 Vitiligo; CRC cis rs6604026 0.922 rs12750269 chr1:93311661 T/C cg22128645 chr1:93425802 FAM69A -0.39 -5.72 -0.3 2.36e-8 Multiple sclerosis; CRC cis rs7904368 0.806 rs7899853 chr10:16857603 A/T cg14835575 chr10:16859367 RSU1 0.45 6.1 0.32 2.99e-9 Ratio of the peak velocity of the mitral E-Wave divided by the peak velocity of the mitral A-wave.; CRC cis rs10080237 0.564 rs2490224 chr6:80809833 G/A cg08355045 chr6:80787529 NA 0.4 6.82 0.35 4.41e-11 Waist circumference adjusted for body mass index;Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction);Waist circumference adjusted for BMI in active individuals; CRC cis rs7640424 0.620 rs34910554 chr3:107816733 C/T cg09227934 chr3:107805635 CD47 -0.48 -6.07 -0.32 3.48e-9 Body mass index; CRC cis rs6952808 0.723 rs11765550 chr7:2027324 G/A cg04267008 chr7:1944627 MAD1L1 -0.79 -11.47 -0.53 7.55e-26 Bipolar disorder and schizophrenia; CRC cis rs1941023 0.606 rs7926219 chr11:60180335 C/T cg08716584 chr11:60157161 MS4A7 -0.47 -7.72 -0.39 1.41e-13 Congenital heart disease (maternal effect); CRC cis rs832540 0.552 rs252924 chr5:56205643 A/G cg12311346 chr5:56204834 C5orf35 -0.58 -8.79 -0.44 8.46e-17 Coronary artery disease; CRC cis rs57590327 0.583 rs13062245 chr3:81833718 G/T cg07356753 chr3:81810745 GBE1 -0.65 -8.89 -0.44 4.25e-17 Extraversion; CRC cis rs6912958 0.874 rs9294381 chr6:88152681 A/T cg08069147 chr6:88032118 GJB7;C6orf162 -0.62 -9.51 -0.46 4.29e-19 Monocyte percentage of white cells; CRC cis rs651907 0.557 rs35850993 chr3:101437433 A/G cg12386194 chr3:101231763 SENP7 0.48 7.04 0.36 1.12e-11 Colorectal cancer; CRC cis rs7618915 0.501 rs6617 chr3:52740182 C/G cg10802521 chr3:52805072 NEK4 -0.57 -9.0 -0.44 1.8e-17 Bipolar disorder; CRC cis rs13191362 1.000 rs73016459 chr6:163066323 C/A cg23758597 chr6:163146217 PARK2 -0.65 -6.58 -0.34 1.91e-10 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs703842 0.642 rs10876994 chr12:58064737 A/C cg00677455 chr12:58241039 CTDSP2 0.56 6.77 0.35 5.8200000000000003e-11 Multiple sclerosis; CRC trans rs11098499 0.779 rs28495013 chr4:120375831 A/C cg25214090 chr10:38739885 LOC399744 0.66 10.47 0.5 2.41e-22 Corneal astigmatism; CRC cis rs9532580 0.710 rs9577090 chr13:41225228 G/T cg21288729 chr13:41239152 FOXO1 0.48 7.48 0.38 6.95e-13 Mean corpuscular hemoglobin; CRC cis rs7605827 0.930 rs10929372 chr2:15662434 A/G cg19274914 chr2:15703543 NA 0.38 5.89 0.31 9.64e-9 Educational attainment (years of education); CRC cis rs9388451 0.513 rs1268069 chr6:126039994 A/C cg05901451 chr6:126070800 HEY2 -0.59 -9.73 -0.47 7.77e-20 Brugada syndrome; CRC cis rs7412746 0.611 rs2271076 chr1:150916657 C/T cg15448220 chr1:150897856 SETDB1 0.46 6.84 0.35 3.98e-11 Melanoma; CRC cis rs9462846 0.691 rs67059212 chr6:42913269 T/G cg21280719 chr6:42927975 GNMT -0.32 -6.23 -0.32 1.41e-9 Blood protein levels; CRC cis rs1018836 0.637 rs7843684 chr8:91470035 G/C cg16814680 chr8:91681699 NA -0.53 -8.26 -0.41 3.72e-15 Ejection fraction in Tripanosoma cruzi seropositivity; CRC cis rs832540 0.564 rs33329 chr5:56145068 T/C cg18230493 chr5:56204884 C5orf35 -0.4 -5.67 -0.3 3.14e-8 Coronary artery disease; CRC cis rs2732480 0.557 rs2732441 chr12:48723324 C/G cg04545296 chr12:48745243 ZNF641 0.36 6.15 0.32 2.19e-9 Hemoglobin concentration;Red blood cell count;Hematocrit; CRC cis rs9329289 0.632 rs2452187 chr10:2551147 C/G cg05625103 chr10:2543513 NA 0.49 7.65 0.39 2.31e-13 Age-related hearing impairment; CRC cis rs9814567 1.000 rs6804770 chr3:134230234 A/T cg06109529 chr3:134205091 CEP63;ANAPC13 -0.81 -12.26 -0.56 1e-28 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs736408 0.546 rs3733046 chr3:52621627 C/T cg10802521 chr3:52805072 NEK4 -0.58 -9.09 -0.45 9.53e-18 Bipolar disorder; CRC cis rs4853036 0.904 rs2278934 chr2:70121197 T/C cg02498382 chr2:70120550 SNRNP27 -0.43 -6.57 -0.34 1.92e-10 Colorectal or endometrial cancer; CRC cis rs78456975 0.699 rs17091772 chr2:1519679 A/C cg12573674 chr2:1569213 NA -0.65 -7.6 -0.39 3.13e-13 Placebo response in major depressive disorder (% change in symptom score); CRC cis rs7662987 0.517 rs1311617 chr4:100012425 T/G cg12011299 chr4:100065546 ADH4 0.49 9.16 0.45 5.61e-18 Smoking initiation; CRC cis rs67478160 0.634 rs2295140 chr14:104216293 C/T cg08213375 chr14:104286397 PPP1R13B 0.57 11.88 0.55 2.46e-27 Schizophrenia; CRC trans rs7613875 0.620 rs11721204 chr3:49982765 C/T cg21659725 chr3:3221576 CRBN 0.47 6.67 0.35 1.06e-10 Body mass index; CRC cis rs2839186 0.872 rs2250213 chr21:47674275 G/A cg11766577 chr21:47581405 C21orf56 -0.39 -5.98 -0.31 5.89e-9 Testicular germ cell tumor; CRC cis rs1570884 0.516 rs2094108 chr13:50171550 G/A cg03651054 chr13:50194643 NA 0.35 7.07 0.36 9.24e-12 Sum basophil neutrophil counts;Sum neutrophil eosinophil counts;Neutrophil count;Myeloid white cell count;Granulocyte count; CRC trans rs57590327 0.503 rs6776737 chr3:81513729 T/C cg23387109 chr10:94051229 MARCH5;CPEB3 -0.44 -6.0 -0.31 5.25e-9 Extraversion; CRC cis rs10504229 1.000 rs59549824 chr8:58186205 A/C cg24829409 chr8:58192753 C8orf71 -0.68 -11.29 -0.53 3.39e-25 Developmental language disorder (linguistic errors); CRC cis rs7259376 0.936 rs17391718 chr19:22554154 A/G cg02657401 chr19:22469223 NA -0.32 -7.02 -0.36 1.3e-11 Menopause (age at onset); CRC trans rs9858542 0.953 rs11715915 chr3:49455330 A/G cg21659725 chr3:3221576 CRBN 0.59 7.94 0.4 3.23e-14 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs8077889 0.672 rs15359 chr17:41843979 C/G cg26893861 chr17:41843967 DUSP3 -1.21 -25.8 -0.82 5.04e-81 Triglycerides; CRC cis rs4481887 0.927 rs4517383 chr1:248426484 C/T cg00666640 chr1:248458726 OR2T12 0.56 9.78 0.47 5.29e-20 Common traits (Other); CRC cis rs4665809 0.567 rs6546848 chr2:26444414 G/C cg04944784 chr2:26401820 FAM59B -0.87 -11.85 -0.55 3.24e-27 Gut microbiome composition (summer); CRC cis rs4478858 0.735 rs7526095 chr1:31797581 C/T cg00250761 chr1:31883323 NA -0.44 -8.5 -0.42 6.71e-16 Alcohol dependence; CRC cis rs6963495 0.818 rs9769403 chr7:105163091 G/A cg02135003 chr7:105160482 PUS7 -0.9 -12.2 -0.56 1.71e-28 Bipolar disorder (body mass index interaction); CRC cis rs1223397 0.938 rs35549743 chr6:13294354 C/T cg00460589 chr6:13274354 PHACTR1 0.5 5.98 0.31 5.93e-9 Blood pressure; CRC cis rs2153535 0.580 rs915351 chr6:8442793 C/T cg21535247 chr6:8435926 SLC35B3 0.48 7.24 0.37 3.19e-12 Motion sickness; CRC trans rs10802346 0.545 rs4478780 chr1:246372241 T/C cg22732515 chr19:44031385 ETHE1 0.61 9.07 0.45 1.1e-17 Fractional exhaled nitric oxide (childhood); CRC cis rs8180040 1.000 rs807931 chr3:47389317 C/T cg10298567 chr3:47292165 KIF9 -0.41 -6.85 -0.35 3.66e-11 Colorectal cancer; CRC cis rs2455601 0.882 rs11042118 chr11:8928791 T/A cg09997546 chr11:8931473 C11orf17;ST5 -0.51 -6.72 -0.35 8.25e-11 Schizophrenia; CRC cis rs2075371 0.830 rs2077671 chr7:133951204 C/T cg11752832 chr7:134001865 SLC35B4 0.44 6.72 0.35 8.13e-11 Mean platelet volume; CRC cis rs11764590 0.715 rs55810445 chr7:2103739 C/T cg23422044 chr7:1970798 MAD1L1 -0.51 -6.04 -0.32 4.23e-9 Neuroticism; CRC cis rs477895 0.838 rs12794145 chr11:64006484 C/T cg19465662 chr11:63993652 NUDT22;TRPT1 0.77 9.12 0.45 7.78e-18 Mean platelet volume; CRC cis rs7666738 0.570 rs1921415 chr4:99093804 C/T cg05340658 chr4:99064831 C4orf37 0.49 7.17 0.37 5.06e-12 Colonoscopy-negative controls vs population controls; CRC cis rs2302190 0.882 rs8073754 chr17:56618030 C/T cg25885038 chr17:56607967 SEPT4 -0.52 -7.88 -0.4 4.84e-14 Vitamin D levels; CRC cis rs2836974 0.602 rs2037925 chr21:40699931 C/T cg17971929 chr21:40555470 PSMG1 -0.65 -9.81 -0.48 4.18e-20 Cognitive function; CRC cis rs1150668 0.796 rs1005125 chr6:28367355 G/A cg03623178 chr6:28175578 NA 0.59 8.64 0.43 2.4e-16 Pubertal anthropometrics; CRC cis rs6502050 0.835 rs11658335 chr17:80084821 C/T cg19223190 chr17:80058835 NA -0.39 -6.24 -0.33 1.31e-9 Life satisfaction; CRC cis rs3806843 0.576 rs155360 chr5:140309016 C/T cg19875535 chr5:140030758 IK 0.43 6.61 0.34 1.54e-10 Depressive symptoms (multi-trait analysis); CRC cis rs9467711 0.559 rs13208916 chr6:26601940 G/A cg12315302 chr6:26189340 HIST1H4D 0.74 5.82 0.31 1.38e-8 Autism spectrum disorder or schizophrenia; CRC cis rs875971 0.862 rs778702 chr7:65864835 G/A cg12463550 chr7:65579703 CRCP 0.49 6.89 0.36 2.88e-11 Aortic root size; CRC trans rs10227393 0.614 rs10239379 chr7:144970348 C/T cg00620628 chr2:238165917 NA 0.48 6.05 0.32 3.93e-9 Coffee consumption; CRC cis rs7086627 0.515 rs11202957 chr10:82209592 A/G cg00277334 chr10:82204260 NA -0.84 -16.95 -0.68 9.58e-47 Post bronchodilator FEV1; CRC cis rs7074356 0.831 rs12764048 chr10:82148963 A/G cg11900509 chr10:81946545 ANXA11 -0.56 -6.26 -0.33 1.23e-9 Borderline personality disorder; CRC cis rs11764590 0.950 rs11514731 chr7:2051503 C/G cg24505167 chr7:1915268 MAD1L1 -0.44 -5.98 -0.31 5.89e-9 Neuroticism; CRC cis rs4253772 0.591 rs73886791 chr22:46687212 A/G cg09491104 chr22:46646882 C22orf40 -0.4 -6.27 -0.33 1.12e-9 LDL cholesterol;Cholesterol, total; CRC cis rs7811142 1.000 rs2406253 chr7:100077273 A/G cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.16 17.05 0.68 3.64e-47 Platelet count; CRC cis rs9491140 0.539 rs12529386 chr6:124678200 A/G cg19267163 chr6:125004984 NKAIN2 0.47 6.39 0.33 5.71e-10 Neuroticism; CRC trans rs800082 0.668 rs7643301 chr3:144293612 G/A cg24215973 chr2:240111563 HDAC4 -0.64 -10.19 -0.49 2.22e-21 Smoking behavior; CRC cis rs7651039 0.641 rs6773682 chr3:15676426 G/A cg16303742 chr3:15540471 COLQ 0.44 6.68 0.35 1.04e-10 Coronary heart disease; CRC cis rs11785693 0.862 rs62491168 chr8:4982290 A/T cg26367366 chr8:4980734 NA 0.8 9.58 0.47 2.49e-19 Neuroticism (multi-trait analysis);Neuroticism; CRC trans rs916888 0.821 rs199507 chr17:44858855 A/G cg10053473 chr17:62856997 LRRC37A3 0.71 8.39 0.42 1.42e-15 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs6933660 0.646 rs9383899 chr6:151781022 G/C cg17179660 chr6:151773299 C6orf211;RMND1 -0.41 -6.19 -0.32 1.76e-9 Menarche (age at onset); CRC cis rs11190604 1.000 rs11190578 chr10:102238953 C/T cg16342193 chr10:102329863 NA -0.36 -5.87 -0.31 1.05e-8 Palmitoleic acid (16:1n-7) levels; CRC cis rs6951245 0.872 rs75493422 chr7:1072890 C/T cg03188948 chr7:1209495 NA 0.64 6.55 0.34 2.2e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs6938 0.618 rs12911254 chr15:75166335 G/A cg14664628 chr15:75095509 CSK -0.58 -9.03 -0.45 1.48e-17 Breast cancer; CRC cis rs2075371 1.000 rs8134 chr7:133974519 A/G cg20476274 chr7:133979776 SLC35B4 0.81 14.98 0.64 4.65e-39 Mean platelet volume; CRC cis rs1008375 1.000 rs3733579 chr4:17694943 A/G cg16339924 chr4:17578868 LAP3 0.49 6.58 0.34 1.89e-10 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs6087990 0.735 rs2424907 chr20:31359819 C/T cg13636640 chr20:31349939 DNMT3B 0.77 14.73 0.63 4.64e-38 Ulcerative colitis; CRC trans rs7142881 0.715 rs34977423 chr14:32127868 G/A cg07250515 chr12:56618133 OBFC2B 0.39 6.19 0.32 1.84e-9 Response to iloperidone treatment (QT prolongation); CRC cis rs2075371 0.501 rs1646654 chr7:134027547 G/C cg11752832 chr7:134001865 SLC35B4 0.43 6.27 0.33 1.16e-9 Mean platelet volume; CRC cis rs798554 0.797 rs798493 chr7:2798731 A/G cg14895029 chr7:2775587 GNA12 -0.48 -7.03 -0.36 1.17e-11 Height; CRC cis rs1153858 1.000 rs4271549 chr15:45652730 G/A cg21132104 chr15:45694354 SPATA5L1 0.6 8.9 0.44 3.91e-17 Homoarginine levels; CRC cis rs11123610 0.520 rs35482526 chr2:3720707 C/G cg19052272 chr2:3704530 ALLC -0.67 -7.84 -0.4 6.27e-14 Response to inhaled corticosteroid treatment in asthma (change in FEV1); CRC cis rs17023223 0.537 rs10923756 chr1:119674648 A/T cg05756136 chr1:119680316 WARS2 -0.54 -7.27 -0.37 2.68e-12 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for BMI in active individuals; CRC cis rs2228479 0.850 rs17233567 chr16:89813821 G/A cg06558623 chr16:89946397 TCF25 1.15 10.8 0.51 1.85e-23 Skin colour saturation; CRC cis rs1799949 0.929 rs799905 chr17:41277187 G/C cg23758822 chr17:41437982 NA 0.93 18.45 0.71 1.11e-52 Menopause (age at onset); CRC cis rs2832191 0.716 rs1984012 chr21:30392472 T/C cg08807101 chr21:30365312 RNF160 0.72 11.56 0.54 3.73e-26 Dental caries; CRC cis rs12745968 0.589 rs7530780 chr1:93130268 C/T cg17283838 chr1:93427260 FAM69A -0.46 -6.17 -0.32 1.96e-9 Bipolar disorder and schizophrenia; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg25101061 chr5:176739547 MXD3 0.41 6.41 0.33 5.1e-10 Liver disease severity in Alagille syndrome; CRC cis rs1448094 1.000 rs1448094 chr12:86343135 G/T cg19622623 chr12:86230825 RASSF9 -0.35 -5.68 -0.3 3.01e-8 Major depressive disorder; CRC cis rs875971 0.862 rs778680 chr7:65840414 G/A cg00343986 chr7:65444356 GUSB 0.41 5.87 0.31 1.09e-8 Aortic root size; CRC cis rs394563 0.601 rs367133 chr6:149797720 T/G cg11245181 chr6:149772854 ZC3H12D -0.43 -6.87 -0.35 3.24e-11 Dupuytren's disease; CRC cis rs11098499 0.863 rs28718422 chr4:120466304 C/A cg24375607 chr4:120327624 NA 0.48 7.45 0.38 8.51e-13 Corneal astigmatism; CRC cis rs10504229 0.683 rs2318143 chr8:58114660 C/T cg24829409 chr8:58192753 C8orf71 -0.54 -7.88 -0.4 4.9e-14 Developmental language disorder (linguistic errors); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg08313788 chr9:115095520 ROD1 0.52 7.22 0.37 3.56e-12 Response to antipsychotic treatment; CRC cis rs8099014 0.861 rs4940705 chr18:56120155 G/A cg12907477 chr18:56117327 MIR122 0.44 5.68 0.3 2.92e-8 Platelet count; CRC cis rs11792861 0.926 rs72607169 chr9:111832471 A/T cg05043794 chr9:111880884 C9orf5 -0.37 -6.62 -0.34 1.43e-10 Menarche (age at onset); CRC cis rs3785574 0.962 rs2584632 chr17:61880641 G/A cg11494091 chr17:61959527 GH2 0.38 5.95 0.31 6.73e-9 Height; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg00385063 chr21:34852302 TMEM50B 0.41 6.55 0.34 2.21e-10 Liver disease severity in Alagille syndrome; CRC cis rs3091242 0.933 rs61775174 chr1:25787313 G/A cg20684491 chr1:25596433 NA -0.43 -7.34 -0.38 1.69e-12 Erythrocyte sedimentation rate; CRC cis rs6701037 0.566 rs10489326 chr1:175134677 A/G cg14847009 chr1:175162515 KIAA0040 0.3 6.66 0.34 1.18e-10 Alcohol dependence; CRC cis rs910316 0.763 rs735452 chr14:75497984 A/G cg03030879 chr14:75389066 RPS6KL1 0.43 6.46 0.34 3.71e-10 Height; CRC cis rs881375 0.934 rs1468671 chr9:123657502 C/G cg09419670 chr9:123605666 PSMD5;LOC253039 0.56 8.14 0.41 8.37e-15 Rheumatoid arthritis; CRC cis rs875971 0.862 rs12698521 chr7:65939489 T/C cg00343986 chr7:65444356 GUSB 0.43 6.29 0.33 1.03e-9 Aortic root size; CRC cis rs394563 0.967 rs447025 chr6:149799128 A/C cg16235748 chr6:149772707 ZC3H12D -0.37 -6.51 -0.34 2.84e-10 Dupuytren's disease; CRC cis rs7224685 0.569 rs2123841 chr17:4022557 G/C cg11204139 chr17:3907470 NA 0.49 6.24 0.33 1.33e-9 Type 2 diabetes; CRC cis rs2239547 0.603 rs9870898 chr3:53092375 A/G cg18404041 chr3:52824283 ITIH1 -0.33 -5.77 -0.3 1.83e-8 Schizophrenia; CRC cis rs7949030 0.591 rs11231156 chr11:62366454 G/A cg13298116 chr11:62369859 EML3;MTA2 0.61 10.71 0.51 3.81e-23 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg15225105 chr11:64808343 SAC3D1 0.44 6.17 0.32 1.96e-9 Response to antipsychotic treatment; CRC cis rs7833790 0.660 rs10091077 chr8:82705464 A/G cg17211192 chr8:82754475 SNX16 -0.45 -6.08 -0.32 3.29e-9 Diastolic blood pressure; CRC cis rs853679 0.517 rs56364346 chr6:28050762 T/G cg15786705 chr6:28176104 NA 0.74 9.47 0.46 5.74e-19 Depression; CRC cis rs1153858 1.000 rs11070457 chr15:45686943 A/C cg21132104 chr15:45694354 SPATA5L1 0.6 8.45 0.42 9.72e-16 Homoarginine levels; CRC cis rs1448094 0.512 rs6539925 chr12:86244358 A/G cg18827107 chr12:86230957 RASSF9 -0.45 -7.42 -0.38 9.97e-13 Major depressive disorder; CRC cis rs11123170 0.543 rs4849180 chr2:113985186 C/G cg21550016 chr2:113992930 PAX8;LOC440839;LOC654433 0.52 6.13 0.32 2.52e-9 Renal function-related traits (BUN); CRC cis rs6541297 0.941 rs6690424 chr1:230278892 C/T cg20703242 chr1:230279135 GALNT2 0.51 8.0 0.4 2.21e-14 Coronary artery disease; CRC cis rs9322193 0.923 rs9688517 chr6:150061791 T/C cg13206674 chr6:150067644 NUP43 0.68 10.3 0.49 9.71e-22 Lung cancer; CRC cis rs9902453 0.934 rs8079028 chr17:28484234 G/T cg26525008 chr17:28256777 EFCAB5;SSH2 0.68 11.07 0.52 2.07e-24 Coffee consumption (cups per day); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg23187205 chr6:109416245 SESN1;C6orf182 0.49 7.03 0.36 1.18e-11 Response to antipsychotic treatment; CRC cis rs1448094 0.512 rs6539929 chr12:86244932 T/C cg19622623 chr12:86230825 RASSF9 -0.42 -6.78 -0.35 5.42e-11 Major depressive disorder; CRC cis rs67478160 0.619 rs3742365 chr14:104198251 A/G cg08213375 chr14:104286397 PPP1R13B 0.58 11.62 0.54 2.11e-26 Schizophrenia; CRC cis rs6460942 0.915 rs62448599 chr7:12453764 C/T cg06484146 chr7:12443880 VWDE -0.78 -8.1 -0.41 1.11e-14 Coronary artery disease; CRC cis rs4689592 0.622 rs2276968 chr4:7070118 T/G cg06697600 chr4:7070879 GRPEL1 -0.57 -7.92 -0.4 3.73e-14 Monocyte percentage of white cells; CRC cis rs7666738 0.830 rs6818045 chr4:99049374 G/A cg05340658 chr4:99064831 C4orf37 0.6 9.35 0.46 1.4e-18 Colonoscopy-negative controls vs population controls; CRC cis rs4819052 1.000 rs733739 chr21:46666210 A/G cg19498844 chr21:46707878 POFUT2;LOC642852 0.84 11.22 0.53 5.79e-25 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg27649522 chr12:12877729 APOLD1 0.48 6.91 0.36 2.51e-11 Response to antipsychotic treatment; CRC cis rs7647973 0.731 rs7617480 chr3:49210732 G/T cg07636037 chr3:49044803 WDR6 -0.57 -6.83 -0.35 4.15e-11 Menarche (age at onset); CRC cis rs12586317 0.620 rs10145433 chr14:35583333 G/A cg05294307 chr14:35346193 BAZ1A -0.59 -6.72 -0.35 7.87e-11 Psoriasis; CRC cis rs769267 0.931 rs2965193 chr19:19454828 G/A cg01262667 chr19:19385393 TM6SF2 -0.37 -6.13 -0.32 2.48e-9 Tonsillectomy; CRC trans rs7647973 0.710 rs1491983 chr3:49639803 G/T cg21659725 chr3:3221576 CRBN -0.66 -7.14 -0.37 5.85e-12 Menarche (age at onset); CRC cis rs4713118 0.615 rs9295747 chr6:27736993 G/T cg15845792 chr6:28175446 NA -0.6 -8.43 -0.42 1.06e-15 Parkinson's disease; CRC cis rs4730250 0.707 rs4730222 chr7:106810293 G/C cg02696742 chr7:106810147 HBP1 -0.65 -6.91 -0.36 2.45e-11 Osteoarthritis; CRC cis rs7772486 0.632 rs9386128 chr6:146049053 G/A cg13319975 chr6:146136371 FBXO30 0.43 6.51 0.34 2.88e-10 Lobe attachment (rater-scored or self-reported); CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg23615959 chr11:3818253 NUP98;PGAP2 -0.52 -6.24 -0.33 1.31e-9 Diisocyanate-induced asthma; CRC cis rs8180040 0.654 rs9837343 chr3:47177388 C/T cg02527881 chr3:46936655 PTH1R -0.34 -5.98 -0.31 5.85e-9 Colorectal cancer; CRC cis rs6066835 0.867 rs11698214 chr20:47359603 G/A cg18078177 chr20:47281410 PREX1 0.6 5.73 0.3 2.25e-8 Multiple myeloma; CRC cis rs832540 0.512 rs33320 chr5:56206529 C/T cg18230493 chr5:56204884 C5orf35 -0.46 -6.67 -0.34 1.1e-10 Coronary artery disease; CRC cis rs1983891 0.826 rs4714476 chr6:41513740 T/C cg20194872 chr6:41519635 FOXP4 0.39 5.65 0.3 3.42e-8 Prostate cancer; CRC cis rs61524473 1 rs61524473 chr15:45646283 T/C cg14582100 chr15:45693742 SPATA5L1 0.28 5.91 0.31 8.44e-9 Metabolite levels (small molecules and protein measures); CRC cis rs7208859 0.673 rs11654914 chr17:29229424 C/G cg13385521 chr17:29058706 SUZ12P 0.65 7.62 0.39 2.68e-13 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC trans rs58106596 0.848 rs2241742 chr2:232574807 C/G cg01370599 chr3:116745421 NA 0.72 8.67 0.43 1.94e-16 White blood cell count;Lymphocyte counts; CRC cis rs6502050 0.835 rs12450189 chr17:80095128 A/C cg11859384 chr17:80120422 CCDC57 -0.37 -5.85 -0.31 1.16e-8 Life satisfaction; CRC cis rs12220238 1.000 rs7081350 chr10:75990328 A/G cg19889307 chr10:75911429 ADK;AP3M1 0.56 5.77 0.3 1.84e-8 Soluble interleukin-2 receptor subunit alpha; CRC cis rs9309711 0.643 rs10188449 chr2:3480366 T/C cg10845886 chr2:3471009 TTC15 -0.39 -6.22 -0.32 1.55e-9 Neurofibrillary tangles; CRC cis rs11098499 0.697 rs35280960 chr4:120257059 G/A cg09307838 chr4:120376055 NA 0.6 8.82 0.44 6.68e-17 Corneal astigmatism; CRC cis rs7113874 0.569 rs10769916 chr11:8598214 G/A cg02811074 chr11:8615871 STK33 -0.35 -6.05 -0.32 3.97e-9 Body mass index in physically active individuals;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs79387448 0.745 rs17027421 chr2:103159882 A/G cg00507830 chr2:103233733 NA 0.51 5.61 0.3 4.25e-8 Gut microbiota (bacterial taxa); CRC cis rs10461617 0.617 rs79742142 chr5:56104377 A/G cg22800045 chr5:56110881 MAP3K1 0.57 6.19 0.32 1.83e-9 Type 2 diabetes; CRC cis rs7591163 1.000 rs2056566 chr2:228713241 G/A cg20647610 chr2:228736258 WDR69 -0.5 -6.76 -0.35 6.37e-11 Blood pressure; CRC cis rs8077889 0.917 rs72836553 chr17:41909851 A/G cg25876840 chr17:41920477 NA 0.62 8.55 0.43 4.6e-16 Triglycerides; CRC cis rs1018836 0.651 rs2339175 chr8:91565805 A/T cg16814680 chr8:91681699 NA -0.73 -11.33 -0.53 2.34e-25 Ejection fraction in Tripanosoma cruzi seropositivity; CRC cis rs9443189 0.762 rs1321162 chr6:76456347 C/T cg01950844 chr6:76311363 SENP6 0.67 9.36 0.46 1.29e-18 Prostate cancer; CRC cis rs6500602 0.673 rs4786513 chr16:4576423 T/C cg08645402 chr16:4508243 NA 0.59 9.29 0.46 2.2e-18 Schizophrenia; CRC cis rs9911578 0.835 rs2301867 chr17:56480074 T/A cg05425664 chr17:57184151 TRIM37 0.45 6.92 0.36 2.35e-11 Intelligence (multi-trait analysis); CRC cis rs2019137 0.868 rs6755639 chr2:113981810 A/G cg11763394 chr2:113992921 PAX8;LOC440839;LOC654433 0.49 7.12 0.37 6.73e-12 Lymphocyte counts; CRC cis rs8180040 0.764 rs12630534 chr3:47001043 T/C cg27129171 chr3:47204927 SETD2 0.65 10.41 0.5 4.08e-22 Colorectal cancer; CRC cis rs739401 0.595 rs2237903 chr11:2967901 C/T cg08508325 chr11:3079039 CARS -0.45 -7.93 -0.4 3.38e-14 Longevity; CRC cis rs1997103 1.000 rs4947503 chr7:55409427 G/T cg17469321 chr7:55412551 NA 0.72 11.16 0.52 9.79e-25 QRS interval (sulfonylurea treatment interaction); CRC cis rs1218582 0.741 rs11264283 chr1:154869552 A/G cg16680214 chr1:154839983 KCNN3 -0.46 -9.04 -0.45 1.36e-17 Prostate cancer; CRC cis rs1799949 1.000 rs4793197 chr17:41231902 C/T cg25072359 chr17:41440525 NA 0.45 6.67 0.34 1.11e-10 Menopause (age at onset); CRC cis rs10540 0.730 rs12789735 chr11:518509 G/A cg21784768 chr11:537496 LRRC56 -0.7 -6.64 -0.34 1.32e-10 Body mass index; CRC cis rs7953508 0.506 rs10777530 chr12:93961110 C/T cg18151635 chr12:93972918 NA -0.78 -11.51 -0.54 5.62e-26 Pubertal anthropometrics; CRC cis rs394563 0.591 rs805026 chr6:149728254 G/C cg07828024 chr6:149772892 ZC3H12D -0.48 -9.05 -0.45 1.26e-17 Dupuytren's disease; CRC trans rs9467711 0.606 rs9393718 chr6:26407482 G/A cg06606381 chr12:133084897 FBRSL1 -0.85 -6.52 -0.34 2.6200000000000003e-10 Autism spectrum disorder or schizophrenia; CRC cis rs9393692 0.537 rs2393594 chr6:26316289 G/C cg00631329 chr6:26305371 NA -0.52 -8.72 -0.43 1.42e-16 Educational attainment; CRC cis rs6952808 0.608 rs6461049 chr7:2017445 C/T cg21782813 chr7:2030301 MAD1L1 -0.46 -8.55 -0.43 4.61e-16 Bipolar disorder and schizophrenia; CRC cis rs826838 0.616 rs1601746 chr12:38626195 G/T cg26384229 chr12:38710491 ALG10B -0.44 -6.44 -0.33 4.24e-10 Heart rate; CRC trans rs2890652 0.702 rs17777246 chr2:142967890 G/A cg00809969 chr7:27181067 HOXA5 -0.67 -6.08 -0.32 3.24e-9 Body mass index; CRC cis rs6502050 0.712 rs8077079 chr17:80059011 C/T cg19223190 chr17:80058835 NA -0.48 -7.72 -0.39 1.39e-13 Life satisfaction; CRC cis rs6662572 0.737 rs4660333 chr1:46462059 T/C cg03123370 chr1:45965343 CCDC163P;MMACHC -0.44 -5.69 -0.3 2.86e-8 Blood protein levels; CRC cis rs9322193 0.962 rs9689269 chr6:150112997 G/A cg13206674 chr6:150067644 NUP43 0.57 8.14 0.41 8.29e-15 Lung cancer; CRC cis rs709400 0.628 rs4906321 chr14:103878882 C/T cg12935359 chr14:103987150 CKB -0.43 -6.76 -0.35 6.42e-11 Body mass index; CRC cis rs10540 1.000 rs12794284 chr11:477623 C/T cg11503833 chr11:492997 NA 0.55 5.74 0.3 2.12e-8 Body mass index; CRC cis rs2760061 0.659 rs708107 chr1:228189495 C/T cg18477163 chr1:228402036 OBSCN 0.41 6.69 0.35 9.37e-11 Diastolic blood pressure; CRC cis rs1760803 0.754 rs6657214 chr1:154206538 C/T cg26808167 chr1:154192205 UBAP2L;C1orf43 -0.37 -6.35 -0.33 7.04e-10 Nicotine dependence; CRC cis rs1580019 0.587 rs7804457 chr7:32557981 A/G cg06627557 chr7:32535165 LSM5;AVL9 0.96 18.4 0.71 1.71e-52 Cognitive ability; CRC cis rs6743376 0.556 rs2441375 chr2:113817268 T/C cg24553058 chr2:113831203 IL1F10 0.43 6.97 0.36 1.78e-11 Inflammatory biomarkers; CRC cis rs977987 0.806 rs12444589 chr16:75454404 A/T cg03315344 chr16:75512273 CHST6 -0.54 -9.08 -0.45 1.01e-17 Dupuytren's disease; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg15239874 chr12:121148841 UNC119B 0.43 6.24 0.33 1.37e-9 Response to antipsychotic treatment; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg01830644 chr10:12110754 DHTKD1 0.43 6.08 0.32 3.42e-9 Response to antipsychotic treatment; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg18071532 chr12:48357234 TMEM106C 0.4 6.75 0.35 6.66e-11 Liver disease severity in Alagille syndrome; CRC cis rs35306767 0.761 rs12359796 chr10:1021479 G/C cg26597838 chr10:835615 NA 0.95 10.6 0.5 8.78e-23 Eosinophil percentage of granulocytes; CRC cis rs10256972 0.552 rs7805591 chr7:1210745 A/G cg23708337 chr7:1209742 NA 0.51 7.75 0.39 1.14e-13 Longevity;Endometriosis; CRC cis rs3008870 1.000 rs2815357 chr1:67491854 T/C cg08660285 chr1:67390436 MIER1;WDR78 1.02 14.74 0.63 4.05e-38 Lymphocyte percentage of white cells; CRC cis rs6951245 1.000 rs74347384 chr7:1072440 G/A cg04025307 chr7:1156635 C7orf50 0.63 6.63 0.34 1.41e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs4481887 0.741 rs4360554 chr1:248553206 C/T cg26353448 chr1:248524236 OR2T4 -0.3 -5.81 -0.31 1.45e-8 Common traits (Other); CRC cis rs6546324 0.625 rs2861698 chr2:67854808 A/G cg15745817 chr2:67799979 NA -0.57 -9.66 -0.47 1.37e-19 Endometriosis; CRC cis rs910316 0.934 rs4903278 chr14:75535019 C/A cg08847533 chr14:75593920 NEK9 0.94 18.4 0.71 1.68e-52 Height; CRC cis rs12682352 0.579 rs7006589 chr8:8668486 A/G cg08975724 chr8:8085496 FLJ10661 0.37 5.62 0.3 4.14e-8 Neuroticism; CRC cis rs524281 0.773 rs10896105 chr11:66002260 A/G cg16950941 chr11:66035639 RAB1B -0.7 -8.04 -0.41 1.67e-14 Electroencephalogram traits; CRC cis rs4665809 0.589 rs4665841 chr2:26448950 G/A cg25036284 chr2:26402008 FAM59B -0.64 -8.5 -0.42 6.51e-16 Gut microbiome composition (summer); CRC cis rs7312933 0.966 rs7977365 chr12:42513127 G/A cg11827402 chr12:42719852 PPHLN1;ZCRB1 0.58 7.45 0.38 8.07e-13 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CRC cis rs6088580 0.634 rs6088512 chr20:33095891 G/A cg08999081 chr20:33150536 PIGU 0.64 11.5 0.54 6.02e-26 Glomerular filtration rate (creatinine); CRC cis rs947211 0.846 rs823155 chr1:205762946 T/C cg24503407 chr1:205819492 PM20D1 0.45 6.4 0.33 5.38e-10 Parkinson's disease; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg07151637 chr22:32149913 DEPDC5 0.37 6.47 0.34 3.6e-10 Liver disease severity in Alagille syndrome; CRC cis rs477895 0.653 rs34113693 chr11:63900123 G/T cg18225595 chr11:63971243 STIP1 0.57 7.54 0.38 4.59e-13 Mean platelet volume; CRC cis rs7089973 0.872 rs7909657 chr10:116629096 C/G cg23260525 chr10:116636907 FAM160B1 0.31 6.75 0.35 6.66e-11 Bipolar disorder or attention deficit hyperactivity disorder; CRC cis rs2019137 1.000 rs2019137 chr2:113973632 G/A cg21610815 chr2:113994035 PAX8;LOC654433;LOC440839 -0.46 -6.45 -0.34 4.02e-10 Lymphocyte counts; CRC cis rs6598955 0.671 rs17163749 chr1:26568165 A/G cg04990556 chr1:26633338 UBXN11 0.57 6.2 0.32 1.69e-9 Obesity-related traits; CRC cis rs10504229 1.000 rs58371676 chr8:58189382 G/A cg01721255 chr8:58191610 C8orf71 0.49 6.17 0.32 2e-9 Developmental language disorder (linguistic errors); CRC cis rs6976053 1.000 rs6976053 chr7:100512119 C/T cg10426581 chr7:100472382 SRRT 0.37 5.69 0.3 2.78e-8 Plasminogen activator inhibitor type 1 levels (PAI-1); CRC cis rs3018066 0.666 rs77934361 chr4:106980535 T/C cg01869342 chr4:106983673 TBCK 0.48 6.26 0.33 1.21e-9 Cancer; CRC cis rs72717009 0.825 rs7515174 chr1:161476949 C/G cg10431340 chr1:161279108 MPZ -0.52 -6.96 -0.36 1.84e-11 Rheumatoid arthritis; CRC cis rs9303401 0.538 rs3785493 chr17:56472119 G/T cg10487724 chr17:56770010 TEX14;RAD51C -0.66 -7.89 -0.4 4.4e-14 Cognitive test performance; CRC cis rs9733 0.503 rs7556451 chr1:150913142 A/G cg15448220 chr1:150897856 SETDB1 0.46 6.84 0.35 3.98e-11 Tonsillectomy; CRC cis rs7618501 0.521 rs952594 chr3:49908023 G/A cg24308560 chr3:49941425 MST1R -0.45 -6.86 -0.35 3.4e-11 Intelligence (multi-trait analysis); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg25019564 chr18:9475492 RALBP1 0.45 6.78 0.35 5.58e-11 Intelligence (multi-trait analysis); CRC cis rs1018836 0.828 rs9297871 chr8:91572731 G/A cg16814680 chr8:91681699 NA -0.63 -9.84 -0.48 3.47e-20 Ejection fraction in Tripanosoma cruzi seropositivity; CRC cis rs11122272 0.735 rs2486734 chr1:231531392 A/G cg06096015 chr1:231504339 EGLN1 0.41 6.19 0.32 1.8e-9 Hemoglobin concentration; CRC cis rs1882538 0.504 rs6951416 chr7:133092278 A/G cg10665199 chr7:133106180 EXOC4 0.55 8.28 0.42 3.21e-15 Intelligence (multi-trait analysis); CRC cis rs13118159 0.550 rs13123016 chr4:1340889 T/C cg16405210 chr4:1374714 KIAA1530 -0.9 -13.46 -0.6 3.44e-33 Longevity; CRC cis rs7615952 1.000 rs7615952 chr3:125649403 A/C cg05084668 chr3:125655381 ALG1L 0.62 9.63 0.47 1.65e-19 Blood pressure (smoking interaction); CRC cis rs1552244 0.882 rs13063098 chr3:10009919 G/A cg02579736 chr3:10068473 FANCD2;CIDECP 0.96 12.46 0.57 1.84e-29 Alzheimer's disease; CRC cis rs908922 0.676 rs7547628 chr1:152527738 T/C cg23254163 chr1:152506842 NA 0.44 8.89 0.44 4.08e-17 Hair morphology; CRC cis rs7043114 0.525 rs10761161 chr9:95262342 C/G cg14631576 chr9:95140430 CENPP -0.32 -6.01 -0.31 4.9e-9 Height; CRC cis rs8014671 0.597 rs1044527 chr14:70833819 C/G cg21512124 chr14:70655805 SLC8A3 -0.31 -6.0 -0.31 5.31e-9 Prostate cancer; CRC cis rs4713118 0.588 rs200994 chr6:27813813 A/C cg02683197 chr6:28174875 NA -0.68 -8.7 -0.43 1.63e-16 Parkinson's disease; CRC cis rs1692580 0.870 rs262680 chr1:2167149 C/T cg24578937 chr1:2090814 PRKCZ 0.38 7.0 0.36 1.49e-11 Coronary artery disease; CRC cis rs9399135 1.000 rs4895435 chr6:135293463 C/A cg22676075 chr6:135203613 NA 0.41 6.18 0.32 1.91e-9 Red blood cell count; CRC cis rs3820928 1.000 rs2163041 chr2:227772480 T/C cg11843606 chr2:227700838 RHBDD1 -0.41 -5.91 -0.31 8.42e-9 Pulmonary function; CRC cis rs1552244 1.000 rs113771705 chr3:10075983 T/C cg13047869 chr3:10149882 C3orf24 0.57 7.76 0.39 1.1e-13 Alzheimer's disease; CRC cis rs12477438 0.501 rs34272114 chr2:99737443 A/C cg14399236 chr2:99771627 LIPT1;TSGA10 0.73 12.08 0.55 4.6e-28 Chronic sinus infection; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg27109030 chr19:2702898 GNG7 0.4 7.08 0.36 8.88e-12 Liver disease severity in Alagille syndrome; CRC cis rs9467711 0.651 rs16891264 chr6:26072445 C/T cg08501292 chr6:25962987 TRIM38 -0.87 -8.19 -0.41 6e-15 Autism spectrum disorder or schizophrenia; CRC cis rs1451375 0.583 rs11575320 chr7:50605298 A/G cg14593290 chr7:50529359 DDC -0.63 -8.67 -0.43 2.05e-16 Malaria; CRC cis rs4713118 0.955 rs9368528 chr6:27683798 G/A cg02683197 chr6:28174875 NA 0.57 7.53 0.38 5.05e-13 Parkinson's disease; CRC cis rs1322512 0.959 rs2623954 chr6:152966001 G/A cg03415253 chr6:152958462 SYNE1 -0.44 -6.77 -0.35 5.99e-11 Tonometry; CRC cis rs1577917 0.958 rs2875456 chr6:86602284 G/A cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.53 -6.57 -0.34 1.96e-10 Response to antipsychotic treatment; CRC cis rs12477438 0.520 rs4588238 chr2:99749350 T/C cg14399236 chr2:99771627 LIPT1;TSGA10 0.81 14.17 0.62 6.37e-36 Chronic sinus infection; CRC cis rs56114371 0.530 rs9357045 chr6:27688927 G/A cg12273811 chr6:28175739 NA 0.47 5.73 0.3 2.25e-8 Breast cancer; CRC cis rs8018808 0.935 rs8018513 chr14:77928288 T/C cg20045696 chr14:77926864 AHSA1 0.36 5.65 0.3 3.54e-8 Myeloid white cell count; CRC cis rs801193 1.000 rs7782320 chr7:66177098 C/T cg18876405 chr7:65276391 NA 0.6 10.49 0.5 2.19e-22 Aortic root size; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg19704520 chr7:100291891 NA 0.4 6.09 0.32 3.08e-9 Intelligence (multi-trait analysis); CRC cis rs2415984 0.622 rs1761025 chr14:46930439 T/C cg14871534 chr14:47121158 RPL10L 0.42 6.0 0.31 5.14e-9 Number of children ever born; CRC cis rs4731207 0.596 rs1871775 chr7:124674652 G/T cg23710748 chr7:124431027 NA -0.4 -6.23 -0.33 1.39e-9 Cutaneous malignant melanoma; CRC cis rs9914988 0.887 rs11652710 chr17:27145075 C/T cg12682573 chr17:27188876 MIR451;MIR144 0.57 7.99 0.4 2.37e-14 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC trans rs2834485 1.000 rs2834484 chr21:35816941 G/T cg07474852 chr4:123073612 NA -0.54 -8.17 -0.41 6.54e-15 Cancer; CRC cis rs12530845 0.673 rs73725437 chr7:135327853 G/A cg23117316 chr7:135346802 PL-5283 -0.45 -5.82 -0.31 1.38e-8 Red blood cell traits; CRC cis rs1065656 0.571 rs2745170 chr16:1835231 G/T cg08610935 chr16:1836813 NUBP2 0.62 9.54 0.47 3.35e-19 Insulin-like growth factors; CRC cis rs9381040 0.655 rs2268194 chr6:41024447 T/C cg09580153 chr6:41068724 NFYA;LOC221442 -0.42 -6.12 -0.32 2.71e-9 Alzheimer's disease (late onset); CRC cis rs28386778 0.897 rs2665832 chr17:61912261 C/T cg07362569 chr17:61921086 SMARCD2 0.39 6.02 0.32 4.54e-9 Prudent dietary pattern; CRC cis rs2404602 0.647 rs2404604 chr15:76991105 A/G cg03037974 chr15:76606532 NA -0.5 -7.28 -0.37 2.45e-12 Blood metabolite levels; CRC cis rs2976388 0.609 rs2257796 chr8:143808667 T/C cg04969067 chr8:143858791 LYNX1 0.46 7.64 0.39 2.35e-13 Urinary tract infection frequency; CRC cis rs1728785 1.000 rs7202306 chr16:68587684 G/A cg02972257 chr16:68554789 NA -0.61 -7.64 -0.39 2.46e-13 Ulcerative colitis; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg12435494 chr20:61493322 TCFL5 0.42 5.97 0.31 6.06e-9 Anxiety disorder; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg05147077 chr5:36606601 SLC1A3 0.43 6.28 0.33 1.05e-9 Intelligence (multi-trait analysis); CRC cis rs11711311 1.000 rs3773682 chr3:113520576 T/C cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.52 -7.07 -0.36 9.26e-12 IgG glycosylation; CRC cis rs7618915 0.547 rs34173654 chr3:52634605 T/C cg10802521 chr3:52805072 NEK4 -0.59 -8.96 -0.44 2.47e-17 Bipolar disorder; CRC cis rs875971 0.862 rs1167399 chr7:65561877 G/A cg18252515 chr7:66147081 NA 0.4 5.9 0.31 9.26e-9 Aortic root size; CRC cis rs6499255 0.904 rs60010276 chr16:69674805 C/T cg04110750 chr16:69646130 NFAT5 -0.53 -7.27 -0.37 2.62e-12 IgE levels; CRC cis rs1707322 0.827 rs10890347 chr1:46242332 A/T cg06784218 chr1:46089804 CCDC17 -0.62 -10.33 -0.49 7.34e-22 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs7772486 0.875 rs2814871 chr6:146312274 G/T cg23711669 chr6:146136114 FBXO30 0.61 10.1 0.49 4.69e-21 Lobe attachment (rater-scored or self-reported); CRC cis rs7618915 0.533 rs35107891 chr3:52613656 G/C cg10802521 chr3:52805072 NEK4 -0.58 -9.01 -0.44 1.68e-17 Bipolar disorder; CRC cis rs992157 0.798 rs4996257 chr2:219162836 C/T cg00012203 chr2:219082015 ARPC2 0.44 6.84 0.35 3.89e-11 Colorectal cancer; CRC cis rs4862750 0.872 rs6830426 chr4:187897270 T/A cg10295955 chr4:187884368 NA -1.06 -28.15 -0.84 1.27e-89 Lobe attachment (rater-scored or self-reported); CRC cis rs7847628 0.550 rs12343516 chr9:123603469 A/C cg09419670 chr9:123605666 PSMD5;LOC253039 0.91 19.03 0.72 5.59e-55 Birth weight; CRC cis rs7924005 0.787 rs10905876 chr10:6174601 C/T cg17191567 chr10:6178319 NA 0.39 5.95 0.31 6.93e-9 Soluble interleukin-2 receptor subunit alpha; CRC cis rs2576037 0.583 rs11660085 chr18:44529603 A/G cg07416455 chr18:44543612 TCEB3CL;KATNAL2 0.59 8.74 0.43 1.19e-16 Personality dimensions; CRC cis rs4737010 0.644 rs506763 chr8:41612487 C/T cg17182837 chr8:41585554 ANK1 0.52 7.49 0.38 6.57e-13 Lymphocyte counts;High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Reticulocyte count;Reticulocyte fraction of red cells;Mean corpuscular volume;Immature fraction of reticulocytes;Mean corpuscular hemoglobin concentration; CRC cis rs2408955 0.522 rs7139330 chr12:48483484 A/C cg15465823 chr12:48382534 COL2A1 -0.37 -6.14 -0.32 2.41e-9 Glycated hemoglobin levels; CRC cis rs1609391 0.561 rs9289523 chr3:136635589 C/G cg15507776 chr3:136538369 TMEM22 0.36 6.6 0.34 1.68e-10 Neuroticism; CRC cis rs11677416 1.000 rs6542094 chr2:113528625 A/G cg27083787 chr2:113543245 IL1A 0.44 6.35 0.33 7.26e-10 Response to antipsychotic treatment in schizophrenia (working memory); CRC cis rs9443645 0.901 rs2050659 chr6:79734369 A/C cg05283184 chr6:79620031 NA -0.62 -9.74 -0.47 7.35e-20 Intelligence (multi-trait analysis); CRC cis rs6121246 0.909 rs6060960 chr20:30394517 G/T cg13852791 chr20:30311386 BCL2L1 -0.67 -10.91 -0.52 7.09e-24 Mean corpuscular hemoglobin; CRC cis rs4689388 0.890 rs6838400 chr4:6295427 C/G cg00701064 chr4:6280414 WFS1 0.75 13.24 0.59 2.21e-32 Type 2 diabetes and other traits;Type 2 diabetes; CRC trans rs11098499 0.866 rs6824111 chr4:120285968 T/A cg25214090 chr10:38739885 LOC399744 0.61 9.66 0.47 1.39e-19 Corneal astigmatism; CRC trans rs629535 0.773 rs569064 chr8:70065967 A/G cg21567404 chr3:27674614 NA 0.92 15.29 0.64 2.9e-40 Dupuytren's disease; CRC cis rs7666738 0.753 rs34164013 chr4:98976333 A/G cg05340658 chr4:99064831 C4orf37 0.6 9.35 0.46 1.41e-18 Colonoscopy-negative controls vs population controls; CRC cis rs79839061 0.518 rs3755961 chr4:895059 A/G cg07828340 chr4:882639 GAK 1.17 11.46 0.53 8.2e-26 Intelligence (multi-trait analysis); CRC cis rs769267 1.000 rs2074090 chr19:19449686 G/T cg20644253 chr19:19431407 KIAA0892;SF4 -0.41 -5.73 -0.3 2.23e-8 Tonsillectomy; CRC cis rs1862618 0.853 rs252919 chr5:56124111 T/C cg03609598 chr5:56110824 MAP3K1 -0.83 -10.44 -0.5 3.21e-22 Initial pursuit acceleration; CRC cis rs7584330 0.554 rs7582964 chr2:238385766 C/T cg08992911 chr2:238395768 MLPH -0.53 -5.92 -0.31 8.31e-9 Prostate cancer; CRC cis rs7091068 0.802 rs10786121 chr10:95419796 G/A cg20715218 chr10:95462985 C10orf4 0.5 5.95 0.31 6.85e-9 Urinary tract infection frequency; CRC cis rs12519773 0.597 rs4342312 chr5:92477890 C/A cg18783429 chr5:92414398 NA 0.3 6.4 0.33 5.2400000000000005e-10 Migraine; CRC cis rs2239547 0.618 rs4687663 chr3:52870618 T/A cg11645453 chr3:52864694 ITIH4 0.61 10.87 0.51 1e-23 Schizophrenia; CRC cis rs7254114 0.578 rs6511727 chr19:11315817 G/T cg02815516 chr19:11306319 KANK2 -0.36 -6.42 -0.33 4.79e-10 Immature fraction of reticulocytes; CRC cis rs1552244 0.882 rs13099507 chr3:10031603 G/A cg08888203 chr3:10149979 C3orf24 0.59 7.3 0.37 2.17e-12 Alzheimer's disease; CRC cis rs10191773 0.589 rs6761440 chr2:112959193 G/A cg23609528 chr2:113191194 RGPD5;RGPD8 0.65 5.65 0.3 3.53e-8 Yeast infection; CRC cis rs10779751 0.666 rs77270747 chr1:11214584 A/C cg08854313 chr1:11322531 MTOR -0.71 -10.01 -0.48 8.94e-21 Body mass index; CRC cis rs8070740 0.838 rs35491297 chr17:5327481 T/G cg25236894 chr17:5323110 RPAIN;NUP88 0.47 6.86 0.35 3.46e-11 Menopause (age at onset); CRC cis rs853679 0.517 rs9368550 chr6:28051803 T/A cg12273811 chr6:28175739 NA 0.71 9.07 0.45 1.08e-17 Depression; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg26666886 chr16:89558024 ANKRD11 0.44 6.22 0.32 1.5e-9 Thyroid stimulating hormone; CRC cis rs4319547 0.695 rs10773152 chr12:122910180 T/C cg05707623 chr12:122985044 ZCCHC8 -0.73 -9.07 -0.45 1.07e-17 Body mass index; CRC cis rs7666738 0.830 rs13119913 chr4:98977983 G/T cg05340658 chr4:99064831 C4orf37 0.57 8.76 0.43 1.05e-16 Colonoscopy-negative controls vs population controls; CRC cis rs6502050 0.835 rs35192339 chr17:80119106 G/A cg22110888 chr17:80059540 CCDC57 0.4 6.38 0.33 5.96e-10 Life satisfaction; CRC cis rs7949030 0.596 rs71490394 chr11:62370155 G/A cg22862634 chr11:62369728 EML3;MTA2 0.57 9.94 0.48 1.54e-20 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; CRC cis rs9858542 1.000 rs13316695 chr3:49684917 C/G cg00383909 chr3:49044727 WDR6 0.47 5.89 0.31 9.58e-9 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs524281 0.692 rs2452681 chr11:65814842 G/A cg16950941 chr11:66035639 RAB1B 0.54 7.51 0.38 5.57e-13 Electroencephalogram traits; CRC cis rs7772486 0.686 rs2142983 chr6:146069701 G/C cg23711669 chr6:146136114 FBXO30 -0.67 -11.06 -0.52 2.19e-24 Lobe attachment (rater-scored or self-reported); CRC cis rs1799949 0.931 rs34410138 chr17:41279770 A/G cg05368731 chr17:41323189 NBR1 0.69 10.5 0.5 1.89e-22 Menopause (age at onset); CRC cis rs3741404 0.791 rs11603192 chr11:63927695 A/G cg19465662 chr11:63993652 NUDT22;TRPT1 0.84 13.88 0.61 8.5e-35 Platelet count; CRC cis rs9942416 0.517 rs116509898 chr5:74994361 C/T cg19683494 chr5:74908142 NA 0.5 6.28 0.33 1.06e-9 Age-related disease endophenotypes; CRC cis rs6662572 0.737 rs6665193 chr1:46347910 G/A cg08644498 chr1:46502608 NA -0.45 -7.07 -0.36 9.42e-12 Blood protein levels; CRC cis rs4665809 0.590 rs10197494 chr2:26445550 A/G cg04944784 chr2:26401820 FAM59B -0.83 -10.74 -0.51 2.96e-23 Gut microbiome composition (summer); CRC cis rs3736485 0.844 rs7181470 chr15:51800882 T/C cg08986416 chr15:51914746 DMXL2 -0.47 -6.82 -0.35 4.28e-11 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs6840360 0.539 rs1443087 chr4:152450095 C/A cg09659197 chr4:152720779 NA 0.33 6.49 0.34 3.21e-10 Intelligence (multi-trait analysis); CRC cis rs13392177 0.660 rs62185964 chr2:219073745 A/G cg00012203 chr2:219082015 ARPC2 -0.49 -7.2 -0.37 4.24e-12 Pyoderma gangrenosum in inflammatory bowel disease; CRC cis rs823143 0.570 rs823084 chr1:205798313 G/T cg14893161 chr1:205819251 PM20D1 0.66 10.57 0.5 1.15e-22 Monocyte percentage of white cells; CRC cis rs11122272 0.701 rs2883799 chr1:231531166 C/G cg06096015 chr1:231504339 EGLN1 0.41 6.18 0.32 1.91e-9 Hemoglobin concentration; CRC cis rs5758511 0.773 rs9680671 chr22:42351477 T/C cg00645731 chr22:42541494 CYP2D7P1 0.43 6.51 0.34 2.74e-10 Birth weight; CRC cis rs4713118 0.539 rs200988 chr6:27819353 A/C cg12172441 chr6:28176163 NA 0.5 6.73 0.35 7.42e-11 Parkinson's disease; CRC cis rs3764400 0.567 rs9890691 chr17:46192936 G/T cg10706073 chr17:46328419 SKAP1 0.58 6.57 0.34 1.99e-10 Body mass index; CRC trans rs7615952 0.512 rs2922175 chr3:125361360 T/C cg16558177 chr4:4109446 NA -0.62 -8.74 -0.43 1.23e-16 Blood pressure (smoking interaction); CRC cis rs7666738 0.830 rs6831588 chr4:98977356 T/G cg17366294 chr4:99064904 C4orf37 0.44 7.44 0.38 8.98e-13 Colonoscopy-negative controls vs population controls; CRC cis rs11958404 0.932 rs6865373 chr5:157436728 A/G cg05962755 chr5:157440814 NA 1.01 12.88 0.58 5.12e-31 IgG glycosylation; CRC cis rs11031096 0.711 rs17283923 chr11:4173841 C/T cg18678763 chr11:4115507 RRM1 -0.36 -5.84 -0.31 1.23e-8 Mean corpuscular volume;Mean corpuscular hemoglobin; CRC cis rs61160187 0.582 rs4647150 chr5:60170605 T/C cg16298547 chr5:60138761 ELOVL7 -0.29 -6.02 -0.32 4.6e-9 Educational attainment (years of education);Educational attainment (college completion); CRC cis rs11711311 1.000 rs9848993 chr3:113497914 T/G cg15478005 chr3:113465772 ATP6V1A;NAA50 0.43 5.94 0.31 7.06e-9 IgG glycosylation; CRC cis rs2637266 0.521 rs4587671 chr10:78398879 A/G cg18941641 chr10:78392320 NA -0.35 -6.05 -0.32 4.03e-9 Pulmonary function; CRC cis rs12458462 0.892 rs2242174 chr18:77458037 T/C cg11879182 chr18:77439856 CTDP1 0.71 11.16 0.52 9.64e-25 Monocyte count; CRC cis rs765787 0.530 rs11854294 chr15:45527996 A/G cg24006582 chr15:45444508 DUOX1 -0.57 -8.61 -0.43 3.11e-16 Uric acid levels; CRC cis rs8072100 0.764 rs2644349 chr17:45641743 G/A cg08085267 chr17:45401833 C17orf57 0.63 10.09 0.49 4.8e-21 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs10927875 0.557 rs1572381 chr1:16344494 G/A cg22431228 chr1:16359049 CLCNKA -0.38 -6.87 -0.35 3.13e-11 Dilated cardiomyopathy; CRC cis rs294883 0.739 rs4144224 chr6:159732620 G/A cg14500486 chr6:159655392 FNDC1 -0.36 -6.16 -0.32 2.11e-9 Coronary artery disease; CRC cis rs3761218 1.000 rs4815603 chr20:3772527 A/T cg25011176 chr20:3776985 CDC25B -0.45 -5.99 -0.31 5.43e-9 Bipolar disorder; CRC cis rs751728 1.000 rs4713684 chr6:33766488 T/C cg25922239 chr6:33757077 LEMD2 0.59 9.05 0.45 1.27e-17 Crohn's disease; CRC cis rs4689388 0.926 rs4234730 chr4:6296343 A/G cg00701064 chr4:6280414 WFS1 0.78 13.64 0.6 7.23e-34 Type 2 diabetes and other traits;Type 2 diabetes; CRC cis rs2440129 0.632 rs2292353 chr17:6903537 C/T cg05657792 chr17:6899758 ALOX12 0.48 8.91 0.44 3.59e-17 Tonsillectomy; CRC trans rs17685 0.672 rs55807301 chr7:75807401 C/A cg19862616 chr7:65841803 NCRNA00174 0.98 16.95 0.68 9.33e-47 Coffee consumption;Coffee consumption (cups per day); CRC cis rs6502050 0.799 rs4789674 chr17:80123200 G/A cg09264619 chr17:80180166 NA -0.35 -5.93 -0.31 7.79e-9 Life satisfaction; CRC cis rs1552244 0.572 rs73117481 chr3:10160132 C/T cg08888203 chr3:10149979 C3orf24 0.71 8.57 0.43 4.18e-16 Alzheimer's disease; CRC trans rs875971 0.660 rs2191268 chr7:66110224 C/T cg06367102 chr7:1192688 ZFAND2A 0.36 5.97 0.31 6.11e-9 Aortic root size; CRC cis rs9818758 0.607 rs67831908 chr3:49313513 T/G cg00383909 chr3:49044727 WDR6 1.1 10.48 0.5 2.33e-22 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; CRC cis rs9584850 0.718 rs6491427 chr13:99113166 A/G cg20487152 chr13:99095054 FARP1 0.43 6.23 0.32 1.41e-9 Neuroticism; CRC cis rs2739330 0.828 rs4820572 chr22:24250355 T/C cg11905131 chr22:24372483 LOC391322 -0.76 -12.11 -0.56 3.64e-28 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs950776 0.518 rs12900783 chr15:78815523 G/A cg06917634 chr15:78832804 PSMA4 0.67 10.7 0.51 3.86e-23 Sudden cardiac arrest; CRC cis rs9322193 0.923 rs12174035 chr6:150084447 A/T cg13206674 chr6:150067644 NUP43 0.51 7.3 0.37 2.16e-12 Lung cancer; CRC cis rs55675132 0.510 rs72687890 chr1:115296524 A/G cg12756093 chr1:115239321 AMPD1 0.52 6.24 0.33 1.34e-9 Schizophrenia; CRC cis rs2739330 0.760 rs1002286 chr22:24257337 A/G cg10819733 chr22:24237672 NA 0.35 6.16 0.32 2.13e-9 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs6088580 0.634 rs6058041 chr20:33018008 A/G cg24642439 chr20:33292090 TP53INP2 0.38 6.31 0.33 9.14e-10 Glomerular filtration rate (creatinine); CRC cis rs9549367 0.789 rs8001506 chr13:113867153 A/C cg18105134 chr13:113819100 PROZ -0.72 -11.11 -0.52 1.41e-24 Platelet distribution width; CRC cis rs2976388 0.590 rs10087426 chr8:143814554 G/A cg22687807 chr8:143858763 LYNX1 -0.46 -7.58 -0.39 3.57e-13 Urinary tract infection frequency; CRC cis rs1552244 0.554 rs3732965 chr3:10048760 A/C cg16606324 chr3:10149918 C3orf24 0.47 7.01 0.36 1.38e-11 Alzheimer's disease; CRC cis rs6860806 0.507 rs2631371 chr5:131703691 G/A cg02033258 chr5:131593261 PDLIM4 -0.39 -6.58 -0.34 1.81e-10 Breast cancer; CRC cis rs2404602 0.716 rs17460201 chr15:76673627 C/T cg23625390 chr15:77176239 SCAPER -0.49 -7.18 -0.37 4.6e-12 Blood metabolite levels; CRC trans rs4824093 0.544 rs73443957 chr22:50305515 T/C cg09872104 chr7:134855509 C7orf49 -0.72 -7.04 -0.36 1.1e-11 Amyotrophic lateral sclerosis (sporadic); CRC cis rs4253772 0.591 rs6008538 chr22:46685963 G/A cg09491104 chr22:46646882 C22orf40 -0.4 -6.4 -0.33 5.3e-10 LDL cholesterol;Cholesterol, total; CRC cis rs7917772 0.582 rs7922780 chr10:104401203 G/A cg11453585 chr10:104263688 ACTR1A;SUFU -0.76 -11.87 -0.55 2.69e-27 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC trans rs1814175 0.935 rs10839329 chr11:49694206 G/A cg21153622 chr11:89784906 NA -0.39 -6.1 -0.32 2.98e-9 Height; CRC cis rs9435341 0.965 rs1335053 chr1:107622823 C/T cg14671364 chr1:107599128 PRMT6 -0.58 -7.9 -0.4 4.18e-14 Facial morphology (factor 21, depth of nasal alae); CRC cis rs7089973 0.872 rs7072356 chr10:116634651 T/C cg23260525 chr10:116636907 FAM160B1 0.32 6.78 0.35 5.43e-11 Bipolar disorder or attention deficit hyperactivity disorder; CRC cis rs875971 0.862 rs11769079 chr7:65842128 G/A cg18876405 chr7:65276391 NA 0.51 8.56 0.43 4.3e-16 Aortic root size; CRC cis rs6840360 0.554 rs61308159 chr4:152728941 G/A cg09659197 chr4:152720779 NA -0.42 -8.5 -0.42 6.53e-16 Intelligence (multi-trait analysis); CRC cis rs644799 0.930 rs2186782 chr11:95649543 G/A cg25622487 chr11:95524042 FAM76B;CEP57 0.72 10.67 0.51 5.07e-23 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs11112613 0.713 rs12580741 chr12:105941328 A/G cg03607813 chr12:105948248 NA -0.76 -10.02 -0.48 8.16e-21 Corrected insulin response;Corrected insulin response adjusted for insulin sensitivity index; CRC cis rs7613875 0.580 rs6808044 chr3:50136165 A/G cg24308560 chr3:49941425 MST1R 0.41 6.19 0.32 1.75e-9 Body mass index; CRC cis rs7647973 0.925 rs6446257 chr3:49253492 A/G cg20833759 chr3:49053208 WDR6;DALRD3 -0.55 -8.27 -0.41 3.36e-15 Menarche (age at onset); CRC cis rs5769707 0.521 rs6009807 chr22:50058922 A/G cg20744362 chr22:50050164 C22orf34 0.32 5.82 0.31 1.38e-8 Monocyte count;Monocyte percentage of white cells; CRC cis rs6141769 0.518 rs28565102 chr20:31285458 T/G cg13636640 chr20:31349939 DNMT3B -0.39 -5.87 -0.31 1.06e-8 Subjective well-being; CRC cis rs8177253 0.665 rs10935074 chr3:133441692 T/G cg24879335 chr3:133465180 TF 0.31 5.88 0.31 9.95e-9 Iron status biomarkers; CRC cis rs1577917 0.883 rs1415749 chr6:86779084 G/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A 0.46 6.05 0.32 3.98e-9 Response to antipsychotic treatment; CRC cis rs9788333 0.695 rs12871086 chr13:21890224 A/T cg06138931 chr13:21896616 NA 0.56 9.29 0.46 2.24e-18 Thiazide-induced adverse metabolic effects in hypertensive patients; CRC cis rs5751901 0.929 rs2330805 chr22:24998619 A/G cg08808123 chr22:24999002 GGT1 -0.4 -5.99 -0.31 5.47e-9 Protein quantitative trait loci; CRC cis rs853679 0.517 rs9380060 chr6:28132603 G/A cg12963246 chr6:28129442 ZNF389 0.49 5.7 0.3 2.71e-8 Depression; CRC cis rs3931020 0.508 rs28568334 chr1:75199299 C/G cg10128416 chr1:75198403 TYW3;CRYZ 0.47 6.37 0.33 6.34e-10 Resistin levels; CRC cis rs2108622 0.727 rs7253873 chr19:15980900 A/G cg13772218 chr19:15982569 NA 0.48 6.73 0.35 7.45e-11 Circulating phylloquinone levels;Vitamin E levels;Acenocoumarol maintenance dosage;Response to Vitamin E supplementation;Metabolite levels;Warfarin maintenance dose; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg20721121 chr10:64565336 ADO 0.45 6.3 0.33 9.5e-10 Anxiety disorder; CRC cis rs28374715 0.578 rs7169543 chr15:41620405 T/C cg18705301 chr15:41695430 NDUFAF1 -1.09 -18.8 -0.72 4.4e-54 Ulcerative colitis; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg22567473 chr15:63902661 HERC1 0.44 5.96 0.31 6.49e-9 Thyroid stimulating hormone; CRC trans rs1973993 0.903 rs2038646 chr1:96940371 C/G cg10631902 chr5:14652156 NA 0.47 8.39 0.42 1.46e-15 Weight; CRC cis rs9649213 0.555 rs7785612 chr7:97933867 T/A cg00277769 chr7:97922759 BAIAP2L1 -0.57 -9.78 -0.47 5.54e-20 Prostate cancer (SNP x SNP interaction); CRC cis rs9902453 0.934 rs4427857 chr17:28457989 A/G cg26525008 chr17:28256777 EFCAB5;SSH2 0.68 11.1 0.52 1.55e-24 Coffee consumption (cups per day); CRC cis rs2290416 0.892 rs62522165 chr8:144675379 C/T cg08017634 chr8:144659831 NAPRT1 0.66 5.81 0.3 1.5e-8 Attention deficit hyperactivity disorder; CRC cis rs6772849 0.930 rs68090762 chr3:128343907 C/T cg08795948 chr3:128337044 NA 0.35 5.97 0.31 6.23e-9 Monocyte percentage of white cells;Monocyte count; CRC cis rs4332037 0.826 rs4721188 chr7:1953615 G/A cg02421172 chr7:1938701 MAD1L1 -0.47 -6.68 -0.35 9.93e-11 Bipolar disorder; CRC cis rs742115 0.563 rs2281063 chr6:11298263 T/C cg25250968 chr6:11318770 NEDD9 -0.39 -7.61 -0.39 2.83e-13 Coronary artery disease; CRC cis rs6951245 0.935 rs78573577 chr7:1089087 C/A cg24642844 chr7:1081250 C7orf50 -0.79 -9.35 -0.46 1.4e-18 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs9372498 0.536 rs62421539 chr6:118730559 C/A cg18833306 chr6:118973337 C6orf204 0.44 5.71 0.3 2.59e-8 Diastolic blood pressure; CRC cis rs2014572 0.901 rs35658377 chr19:57755627 T/G cg24459738 chr19:57751996 ZNF805 -0.52 -8.14 -0.41 8.01e-15 Hyperactive-impulsive symptoms; CRC cis rs2153535 0.580 rs1115079 chr6:8449615 G/C cg21535247 chr6:8435926 SLC35B3 0.5 7.5 0.38 6.06e-13 Motion sickness; CRC cis rs10028773 0.700 rs7690338 chr4:120256468 C/G cg24375607 chr4:120327624 NA 0.47 7.45 0.38 8.16e-13 Educational attainment; CRC cis rs6604026 0.630 rs2263247 chr1:93364067 T/C cg17283838 chr1:93427260 FAM69A -0.45 -5.87 -0.31 1.07e-8 Multiple sclerosis; CRC cis rs7487075 0.619 rs7311504 chr12:46830776 G/A cg22049899 chr12:47219821 SLC38A4 0.32 5.89 0.31 9.68e-9 Itch intensity from mosquito bite; CRC cis rs11212617 0.905 rs672964 chr11:108125471 C/G cg01991180 chr11:108092276 ATM;NPAT 0.39 5.65 0.3 3.46e-8 Response to metformin in type 2 diabetes (glycemic); CRC cis rs1799949 1.000 rs72829113 chr17:41181835 C/T cg01879757 chr17:41196368 BRCA1 -0.41 -6.06 -0.32 3.7e-9 Menopause (age at onset); CRC cis rs9322193 0.923 rs12174716 chr6:149965623 C/T cg07701084 chr6:150067640 NUP43 0.54 7.98 0.4 2.52e-14 Lung cancer; CRC trans rs1005277 0.579 rs2474586 chr10:38418882 T/C cg17830980 chr10:43048298 ZNF37B -0.59 -9.84 -0.48 3.38e-20 Extrinsic epigenetic age acceleration; CRC cis rs1035144 0.506 rs7150858 chr14:81280425 T/C cg06600135 chr14:81408086 NA -0.41 -6.09 -0.32 3.17e-9 Male sexual orientation; CRC cis rs9372498 0.536 rs72969531 chr6:118729974 C/A cg18833306 chr6:118973337 C6orf204 0.44 5.71 0.3 2.59e-8 Diastolic blood pressure; CRC cis rs4731207 0.565 rs1904972 chr7:124669687 T/C cg23710748 chr7:124431027 NA -0.39 -6.15 -0.32 2.22e-9 Cutaneous malignant melanoma; CRC cis rs1865760 0.566 rs9348706 chr6:26065481 G/C cg17691542 chr6:26056736 HIST1H1C 0.56 8.53 0.43 5.25e-16 Height; CRC cis rs12541635 1.000 rs1366965 chr8:107085224 T/A cg10147462 chr8:107024639 NA -0.39 -6.48 -0.34 3.36e-10 Age of smoking initiation; CRC cis rs950169 0.544 rs2036949 chr15:85163605 T/C cg11189052 chr15:85197271 WDR73 0.64 9.31 0.46 1.88e-18 Schizophrenia; CRC cis rs6121246 0.529 rs6058152 chr20:30178107 G/A cg18721089 chr20:30220636 NA -0.53 -7.92 -0.4 3.76e-14 Mean corpuscular hemoglobin; CRC cis rs10504229 0.683 rs56058640 chr8:58128862 C/T cg02290350 chr8:58132656 NA -0.58 -8.16 -0.41 7.29e-15 Developmental language disorder (linguistic errors); CRC cis rs10905065 0.931 rs6602240 chr10:5816751 C/A cg11519256 chr10:5708881 ASB13 -0.42 -5.89 -0.31 9.37e-9 Menopause (age at onset); CRC cis rs5753618 0.583 rs2899164 chr22:31790289 G/A cg07713946 chr22:31675144 LIMK2 0.42 6.24 0.33 1.35e-9 Colorectal cancer; CRC cis rs3540 0.597 rs1978149 chr15:91036976 A/G cg22089800 chr15:90895588 ZNF774 0.56 9.2 0.45 4.12e-18 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; CRC cis rs1163251 0.837 rs592762 chr1:120247355 A/G cg19096424 chr1:120255104 PHGDH 0.41 5.84 0.31 1.29e-8 Blood metabolite levels; CRC cis rs6968419 0.674 rs1918912 chr7:115906373 C/T cg02561103 chr7:115862891 TES -0.42 -6.32 -0.33 8.33e-10 Intraocular pressure; CRC cis rs28386778 0.742 rs3020617 chr17:61947303 A/G cg22520471 chr17:61851767 DDX42;CCDC47 0.71 10.69 0.51 4.37e-23 Prudent dietary pattern; CRC cis rs7772486 0.790 rs2265918 chr6:146219164 A/G cg23711669 chr6:146136114 FBXO30 0.71 12.63 0.57 4.28e-30 Lobe attachment (rater-scored or self-reported); CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg06491456 chr7:7606812 MIOS -0.34 -5.96 -0.31 6.34e-9 Myopia (pathological); CRC cis rs394563 0.591 rs237019 chr6:149727064 G/A cg07828024 chr6:149772892 ZC3H12D -0.49 -9.09 -0.45 9.28e-18 Dupuytren's disease; CRC cis rs7208859 0.673 rs9907197 chr17:29018263 C/T cg01831904 chr17:28903510 LRRC37B2 -0.53 -5.94 -0.31 7.38e-9 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs2070488 0.965 rs3762788 chr3:38493852 C/A cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.91 17.03 0.68 4.35e-47 Electrocardiographic conduction measures; CRC cis rs1322512 1.000 rs2800632 chr6:153008632 C/A cg03415253 chr6:152958462 SYNE1 0.39 6.01 0.31 4.94e-9 Tonometry; CRC cis rs911119 0.913 rs6048922 chr20:23578116 G/C cg16589663 chr20:23618590 CST3 0.41 5.71 0.3 2.51e-8 Chronic kidney disease; CRC cis rs17253792 0.822 rs112238223 chr14:56056144 C/A cg01858014 chr14:56050164 KTN1 -0.85 -6.73 -0.35 7.73e-11 Putamen volume; CRC cis rs2777491 1.000 rs7167729 chr15:41721042 G/A cg18705301 chr15:41695430 NDUFAF1 -0.74 -12.68 -0.57 2.79e-30 Ulcerative colitis; CRC cis rs910187 0.596 rs12329631 chr20:45794427 C/T cg27589058 chr20:45804311 EYA2 -0.37 -6.6 -0.34 1.6e-10 Migraine; CRC cis rs6942756 1.000 rs56026912 chr7:128913937 A/G cg02491457 chr7:128862824 NA -0.75 -10.32 -0.49 8.13e-22 White matter hyperintensity burden; CRC cis rs8072100 0.817 rs6505049 chr17:45675781 G/A cg08085267 chr17:45401833 C17orf57 0.58 9.06 0.45 1.22e-17 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs11997175 0.624 rs4355732 chr8:33676920 A/C ch.8.33884649F chr8:33765107 NA 0.44 6.26 0.33 1.23e-9 Body mass index; CRC cis rs2404602 0.684 rs8037847 chr15:76856551 C/T cg03037974 chr15:76606532 NA -0.51 -7.66 -0.39 2.13e-13 Blood metabolite levels; CRC cis rs10155981 0.510 rs78815495 chr7:22584529 C/T cg05062323 chr7:22590069 NA -0.63 -6.73 -0.35 7.7e-11 Bilirubin levels; CRC cis rs2637266 0.538 rs11001803 chr10:78269701 A/G cg18941641 chr10:78392320 NA -0.35 -5.82 -0.31 1.43e-8 Pulmonary function; CRC cis rs2011503 0.883 rs17216041 chr19:19366643 C/T cg11584989 chr19:19387371 SF4 0.52 6.17 0.32 1.98e-9 Bipolar disorder; CRC trans rs916888 0.610 rs142167 chr17:44795234 C/T cg01341218 chr17:43662625 NA -0.61 -7.48 -0.38 6.7e-13 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs2710642 0.927 rs6705798 chr2:63259881 C/T cg17519650 chr2:63277830 OTX1 0.5 6.78 0.35 5.42e-11 LDL cholesterol levels;LDL cholesterol; CRC cis rs765787 0.530 rs1706835 chr15:45517884 G/A cg24006582 chr15:45444508 DUOX1 -0.57 -8.65 -0.43 2.39e-16 Uric acid levels; CRC trans rs61931739 0.500 rs11053280 chr12:34559297 G/T cg26384229 chr12:38710491 ALG10B 0.67 8.74 0.43 1.21e-16 Morning vs. evening chronotype; CRC cis rs2730245 0.550 rs2709860 chr7:158651156 A/T cg01943577 chr7:158741284 NA -0.4 -5.82 -0.31 1.42e-8 Height; CRC cis rs1046896 0.514 rs9894705 chr17:80823758 A/C cg17346650 chr17:80929145 B3GNTL1 -0.48 -7.27 -0.37 2.62e-12 Glycated hemoglobin levels; CRC cis rs847577 0.609 rs6465657 chr7:97816327 C/T cg21770322 chr7:97807741 LMTK2 0.87 19.51 0.73 6.95e-57 Breast cancer; CRC cis rs7954584 0.813 rs12827200 chr12:122451278 G/A cg21171335 chr12:122356390 WDR66 0.39 5.8 0.3 1.52e-8 Mean corpuscular volume; CRC cis rs780096 0.526 rs1260342 chr2:27663416 G/T cg22903471 chr2:27725779 GCKR -0.37 -6.05 -0.32 4.04e-9 Total body bone mineral density; CRC cis rs7552404 0.960 rs12134854 chr1:76137606 A/G cg10523679 chr1:76189770 ACADM 0.78 10.95 0.52 5.45e-24 Blood metabolite levels;Acylcarnitine levels; CRC cis rs561341 0.783 rs512698 chr17:30292507 G/T cg12193833 chr17:30244370 NA -0.74 -8.72 -0.43 1.45e-16 Hip circumference adjusted for BMI; CRC cis rs4663969 0.839 rs7572563 chr2:234617236 G/A cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.43 -6.57 -0.34 1.98e-10 Total bilirubin levels in HIV-1 infection; CRC cis rs4689388 0.926 rs9998835 chr4:6293237 C/G cg14416269 chr4:6271139 WFS1 0.39 6.43 0.33 4.56e-10 Type 2 diabetes and other traits;Type 2 diabetes; CRC cis rs10751667 0.666 rs10794354 chr11:954615 A/T cg23136738 chr11:925521 AP2A2 -0.42 -7.05 -0.36 1.03e-11 Alzheimer's disease (late onset); CRC cis rs9837602 1.000 rs9833888 chr3:99723580 G/T cg07805332 chr3:99536008 MIR548G;C3orf26 -0.48 -6.34 -0.33 7.79e-10 Breast cancer; CRC trans rs61931739 0.500 rs10844848 chr12:34409705 A/C cg26384229 chr12:38710491 ALG10B 0.66 8.87 0.44 4.62e-17 Morning vs. evening chronotype; CRC cis rs9527 0.544 rs11191549 chr10:104846797 C/T cg04362960 chr10:104952993 NT5C2 0.59 8.17 0.41 6.62e-15 Arsenic metabolism; CRC cis rs561341 1.000 rs693116 chr17:30246124 C/T cg23018236 chr17:30244563 NA -0.66 -7.89 -0.4 4.54e-14 Hip circumference adjusted for BMI; CRC cis rs6908034 0.607 rs34109983 chr6:19808042 G/A cg02682789 chr6:19804855 NA 0.78 6.83 0.35 4.16e-11 Endometriosis;Deep ovarian and/or rectovaginal disease with dense adhesions; CRC cis rs6088590 0.687 rs6088580 chr20:33285053 G/C cg24642439 chr20:33292090 TP53INP2 0.46 8.04 0.41 1.68e-14 Coronary artery disease; CRC cis rs10924970 0.967 rs12739707 chr1:235466564 C/G cg26050004 chr1:235667680 B3GALNT2 0.42 6.23 0.32 1.45e-9 Asthma; CRC cis rs9814567 1.000 rs11706117 chr3:134212526 T/C cg06541857 chr3:134203789 ANAPC13;CEP63 -0.39 -5.65 -0.3 3.56e-8 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs7412746 0.658 rs6656535 chr1:150940357 G/T cg18016565 chr1:150552671 MCL1 0.44 6.17 0.32 2.03e-9 Melanoma; CRC cis rs12908161 1.000 rs12911736 chr15:85240008 A/G cg11189052 chr15:85197271 WDR73 0.63 9.07 0.45 1.07e-17 Schizophrenia; CRC trans rs9914544 0.545 rs2892015 chr17:18786849 C/T cg21372672 chr17:16614065 CCDC144A -0.39 -6.18 -0.32 1.93e-9 Educational attainment (years of education); CRC cis rs4880487 0.888 rs67456501 chr10:1252400 G/A cg03183215 chr10:1252341 ADARB2 -0.3 -6.37 -0.33 6.38e-10 Migraine; CRC cis rs870825 0.616 rs1401358 chr4:185640057 C/T cg04058563 chr4:185651563 MLF1IP 0.71 9.33 0.46 1.56e-18 Blood protein levels; CRC cis rs1448094 0.967 rs2405789 chr12:86320466 C/T cg02569458 chr12:86230093 RASSF9 -0.36 -6.29 -0.33 1.03e-9 Major depressive disorder; CRC cis rs9549367 0.756 rs2302756 chr13:113900197 G/A cg18105134 chr13:113819100 PROZ 0.68 10.07 0.49 5.66e-21 Platelet distribution width; CRC cis rs28386778 0.863 rs3826341 chr17:61819222 C/A cg23090583 chr17:61904693 PSMC5;FTSJ3 1.03 19.94 0.74 1.46e-58 Prudent dietary pattern; CRC cis rs41005 1.000 rs12692349 chr2:8114312 G/A cg03155496 chr2:8117019 LOC339788 -0.39 -6.88 -0.35 3.12e-11 Response to anti-TNF therapy in rheumatoid arthritis; CRC cis rs733592 0.965 rs1978161 chr12:48467721 A/G cg21466736 chr12:48725269 NA 0.47 7.3 0.37 2.11e-12 Plateletcrit; CRC cis rs11098499 0.874 rs6851169 chr4:120117510 T/C cg09307838 chr4:120376055 NA 0.61 8.95 0.44 2.69e-17 Corneal astigmatism; CRC trans rs2727020 0.796 rs7131672 chr11:49274421 A/C cg15704280 chr7:45808275 SEPT13 0.62 8.16 0.41 7.21e-15 Coronary artery disease; CRC cis rs9372253 1.000 rs9384740 chr6:110716207 G/A cg01119278 chr6:110721349 DDO -0.37 -6.06 -0.32 3.63e-9 Platelet distribution width; CRC cis rs7119 0.700 rs2867311 chr15:77902191 A/C cg27398640 chr15:77910606 LINGO1 0.46 8.61 0.43 3.14e-16 Type 2 diabetes; CRC trans rs2055729 0.710 rs114038384 chr8:9737519 T/A cg08975724 chr8:8085496 FLJ10661 0.5 6.23 0.32 1.46e-9 Multiple myeloma (hyperdiploidy); CRC cis rs3931020 0.508 rs11485298 chr1:75217752 C/T cg10128416 chr1:75198403 TYW3;CRYZ 0.48 6.68 0.35 1e-10 Resistin levels; CRC cis rs3008870 0.920 rs975452 chr1:67480190 A/T cg08660285 chr1:67390436 MIER1;WDR78 1.04 15.42 0.65 9.52e-41 Lymphocyte percentage of white cells; CRC cis rs9894429 0.646 rs7406825 chr17:79619188 C/T cg21028142 chr17:79581711 NPLOC4 0.34 7.02 0.36 1.25e-11 Eye color traits; CRC cis rs9916302 0.904 rs4794813 chr17:37670994 A/T cg07936489 chr17:37558343 FBXL20 -0.81 -12.36 -0.56 4.32e-29 Glomerular filtration rate (creatinine); CRC cis rs9527 0.568 rs1926036 chr10:104883812 C/T cg04362960 chr10:104952993 NT5C2 0.6 8.31 0.42 2.6e-15 Arsenic metabolism; CRC cis rs704795 0.805 rs1728926 chr2:27612937 A/G cg12000995 chr2:27665139 KRTCAP3 -0.3 -6.18 -0.32 1.88e-9 Menopause (age at onset); CRC trans rs7730934 1.000 rs6450357 chr5:55269996 T/C cg10323188 chr3:28613979 NA 0.51 5.97 0.31 6.05e-9 Blood protein levels; CRC cis rs11148252 0.595 rs4884522 chr13:53053768 C/A cg02158880 chr13:53174818 NA 0.55 8.78 0.44 9e-17 Lewy body disease; CRC cis rs7487075 0.786 rs4768694 chr12:46677658 T/A cg22049899 chr12:47219821 SLC38A4 0.32 6.11 0.32 2.84e-9 Itch intensity from mosquito bite; CRC cis rs11098499 0.909 rs7659501 chr4:120371552 G/T cg24375607 chr4:120327624 NA 0.51 7.98 0.4 2.49e-14 Corneal astigmatism; CRC trans rs561341 1.000 rs56903735 chr17:30254393 T/A cg20587970 chr11:113659929 NA -1.14 -16.86 -0.68 2.12e-46 Hip circumference adjusted for BMI; CRC cis rs1997103 0.954 rs6593222 chr7:55372932 A/C cg17469321 chr7:55412551 NA 0.72 11.04 0.52 2.6e-24 QRS interval (sulfonylurea treatment interaction); CRC trans rs12478296 0.685 rs6705935 chr2:242995110 C/T cg18288967 chr1:45987694 PRDX1 0.68 7.26 0.37 2.87e-12 Obesity-related traits; CRC cis rs11098499 0.874 rs9995277 chr4:120108603 G/A cg09307838 chr4:120376055 NA 0.61 8.87 0.44 4.6e-17 Corneal astigmatism; CRC cis rs2120019 0.935 rs34913788 chr15:75372617 A/C cg17294928 chr15:75287854 SCAMP5 -0.73 -10.91 -0.52 7.25e-24 Blood trace element (Zn levels); CRC cis rs7737355 0.947 rs10463887 chr5:130776854 C/G cg06307176 chr5:131281290 NA -0.42 -6.24 -0.33 1.32e-9 Life satisfaction; CRC cis rs853679 0.517 rs9368557 chr6:28131537 T/C cg18032046 chr6:28092343 ZSCAN16 -0.51 -5.93 -0.31 7.47e-9 Depression; CRC cis rs11203032 0.831 rs4511206 chr10:90968759 C/T cg16672925 chr10:90967113 CH25H 0.47 6.0 0.31 5.19e-9 Heart failure; CRC cis rs9322193 0.887 rs3777949 chr6:149917157 G/A cg05861140 chr6:150128134 PCMT1 -0.38 -6.19 -0.32 1.76e-9 Lung cancer; CRC cis rs7107174 1.000 rs2510040 chr11:77944548 T/A cg02023728 chr11:77925099 USP35 0.55 8.31 0.42 2.48e-15 Testicular germ cell tumor; CRC cis rs2760061 0.603 rs697761 chr1:228192397 G/A cg02753203 chr1:228287806 NA 0.87 12.74 0.57 1.71e-30 Diastolic blood pressure; CRC trans rs13046373 0.905 rs4816372 chr21:32077414 A/T cg03856714 chr2:96658020 NA -0.43 -6.4 -0.33 5.32e-10 HDL cholesterol; CRC trans rs6703335 0.870 rs10803142 chr1:243598234 A/G cg07754938 chr3:48885314 PRKAR2A 0.42 5.97 0.31 6.01e-9 Schizophrenia;Schizophrenia, schizoaffective disorder or bipolar disorder; CRC cis rs7591163 1.000 rs7591163 chr2:228715375 C/T cg01216370 chr2:228736459 WDR69 -0.45 -5.72 -0.3 2.36e-8 Blood pressure; CRC cis rs1552244 0.882 rs3846168 chr3:9996925 C/T cg10729496 chr3:10149963 C3orf24 0.48 6.31 0.33 9.01e-10 Alzheimer's disease; CRC cis rs11112613 0.818 rs73184099 chr12:106018143 A/G cg03607813 chr12:105948248 NA 0.62 6.61 0.34 1.55e-10 Corrected insulin response;Corrected insulin response adjusted for insulin sensitivity index; CRC cis rs394563 0.559 rs13219868 chr6:149686518 T/G cg07828024 chr6:149772892 ZC3H12D 0.48 9.03 0.45 1.5e-17 Dupuytren's disease; CRC cis rs7586879 0.796 rs916484 chr2:25082588 A/C cg22495460 chr2:25135724 ADCY3 -0.81 -13.57 -0.6 1.24e-33 Body mass index; CRC cis rs12472274 0.817 rs12621791 chr2:239104061 G/A cg17459225 chr2:239074497 NA 0.84 14.03 0.61 2.31e-35 Phospholipid levels (plasma); CRC cis rs62244186 1.000 rs62244186 chr3:44739783 G/A cg15687855 chr3:44754131 ZNF502 -0.36 -6.09 -0.32 3.16e-9 Depressive symptoms; CRC cis rs12594515 1.000 rs12911309 chr15:45985719 G/C cg01629716 chr15:45996671 NA 0.4 8.25 0.41 3.97e-15 Waist circumference;Weight; CRC cis rs2084637 0.931 rs1450796 chr11:122395018 T/A cg21585512 chr11:122030076 LOC399959 -0.41 -7.49 -0.38 6.44e-13 Stroke; CRC cis rs7613875 0.600 rs2624848 chr3:50165101 T/C cg24110177 chr3:50126178 RBM5 0.6 9.12 0.45 7.8e-18 Body mass index; CRC cis rs1005277 0.579 rs2504143 chr10:38383706 C/T cg25517755 chr10:38738941 LOC399744 -0.44 -6.37 -0.33 6.29e-10 Extrinsic epigenetic age acceleration; CRC cis rs6545883 0.501 rs935860 chr2:61406561 G/C cg10580144 chr2:61372316 C2orf74 0.33 7.5 0.38 6.18e-13 Tuberculosis; CRC cis rs2228479 0.850 rs2286393 chr16:89809548 C/A cg19635926 chr16:89946313 TCF25 0.67 6.1 0.32 2.97e-9 Skin colour saturation; CRC cis rs7119 0.717 rs11629652 chr15:77779951 C/A cg17802220 chr15:77601643 NA -0.46 -6.68 -0.35 1.01e-10 Type 2 diabetes; CRC cis rs926938 0.618 rs3121506 chr1:115363207 T/G cg12756093 chr1:115239321 AMPD1 0.57 8.39 0.42 1.48e-15 Autism; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg13415434 chr3:49044522 P4HTM;WDR6 0.52 6.88 0.35 3.11e-11 Thyroid stimulating hormone; CRC cis rs9398803 0.865 rs1578060 chr6:126712247 G/C cg19875578 chr6:126661172 C6orf173 0.41 5.63 0.3 3.95e-8 Male-pattern baldness; CRC trans rs7618501 0.573 rs2624824 chr3:50088266 T/C cg21659725 chr3:3221576 CRBN -0.53 -8.28 -0.42 3.03e-15 Intelligence (multi-trait analysis); CRC cis rs7617773 0.743 rs11715876 chr3:48377922 G/A cg11946769 chr3:48343235 NME6 0.74 9.91 0.48 2.03e-20 Coronary artery disease; CRC cis rs78456975 1.000 rs13431491 chr2:1553808 T/A cg26248373 chr2:1572462 NA -0.67 -7.24 -0.37 3.16e-12 Placebo response in major depressive disorder (% change in symptom score); CRC cis rs6665290 0.836 rs12593 chr1:227172290 A/G cg10327440 chr1:227177885 CDC42BPA 1.03 21.64 0.77 3.44e-65 Myeloid white cell count; CRC cis rs12995491 0.731 rs13019346 chr2:88509321 A/G cg04511125 chr2:88470314 THNSL2 -0.4 -5.94 -0.31 7.19e-9 Response to metformin (IC50); CRC cis rs4689388 0.889 rs4629534 chr4:6294124 G/T cg25554036 chr4:6271136 WFS1 0.53 8.71 0.43 1.54e-16 Type 2 diabetes and other traits;Type 2 diabetes; CRC trans rs9409565 0.826 rs9409546 chr9:97209066 T/C cg05679027 chr9:99775184 HIATL2 -0.41 -6.15 -0.32 2.24e-9 Colorectal cancer (alcohol consumption interaction); CRC cis rs9649465 1.000 rs2896334 chr7:123367705 A/C cg03229431 chr7:123269106 ASB15 -0.36 -5.61 -0.3 4.22e-8 Migraine; CRC cis rs6831352 0.840 rs35073321 chr4:100053276 G/A cg13256891 chr4:100009986 ADH5 -0.66 -8.89 -0.44 4.04e-17 Alcohol dependence; CRC cis rs6879260 1.000 rs7706951 chr5:179733407 C/T cg13944838 chr5:179740914 GFPT2 -0.66 -10.29 -0.49 1.01e-21 Height; CRC cis rs425277 1.000 rs421992 chr1:2077260 C/T cg24578937 chr1:2090814 PRKCZ 0.66 11.81 0.55 4.44e-27 Height; CRC cis rs6976053 0.868 rs10953305 chr7:100492568 G/A cg10426581 chr7:100472382 SRRT 0.38 5.8 0.3 1.57e-8 Plasminogen activator inhibitor type 1 levels (PAI-1); CRC cis rs9787249 1.000 rs9787249 chr1:40212878 G/A cg01941586 chr1:40203715 PPIE -0.44 -6.11 -0.32 2.75e-9 Blood protein levels; CRC cis rs9467711 0.606 rs2072806 chr6:26385093 C/G cg16898833 chr6:26189333 HIST1H4D 0.97 7.93 0.4 3.43e-14 Autism spectrum disorder or schizophrenia; CRC cis rs6903823 0.508 rs1778484 chr6:28240798 A/G cg21251018 chr6:28226885 NKAPL 0.55 9.34 0.46 1.51e-18 Pulmonary function; CRC cis rs911555 0.755 rs4143998 chr14:103955247 T/C cg24130564 chr14:104152367 KLC1 -0.41 -5.72 -0.3 2.43e-8 Intelligence (multi-trait analysis); CRC cis rs79349575 0.783 rs2088139 chr17:47000110 C/T cg00947319 chr17:47005597 UBE2Z -0.34 -5.87 -0.31 1.06e-8 Type 2 diabetes; CRC cis rs4423214 0.840 rs1790328 chr11:71148038 G/A cg13043300 chr11:71146211 DHCR7 -0.44 -6.01 -0.31 4.82e-9 Vitamin D levels; CRC cis rs78456975 0.941 rs13423300 chr2:1553809 C/A cg26248373 chr2:1572462 NA -0.67 -7.24 -0.37 3.16e-12 Placebo response in major depressive disorder (% change in symptom score); CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg14094681 chr14:78174204 C14orf156;ALKBH1 0.46 6.37 0.33 6.26e-10 Anxiety disorder; CRC cis rs990171 1.000 rs2270297 chr2:102992675 T/C cg03938978 chr2:103052716 IL18RAP 0.46 5.82 0.31 1.37e-8 Lymphocyte counts; CRC cis rs9462027 0.628 rs7742652 chr6:34667075 G/A cg07306190 chr6:34760872 UHRF1BP1 0.35 6.28 0.33 1.1e-9 Systemic lupus erythematosus; CRC cis rs73206853 0.614 rs12322130 chr12:110512408 C/T cg12870014 chr12:110450643 ANKRD13A 0.79 7.17 0.37 5.14e-12 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC cis rs2576037 0.623 rs2571000 chr18:44580347 G/A cg19077165 chr18:44547161 KATNAL2 0.65 10.18 0.49 2.49e-21 Personality dimensions; CRC trans rs9329221 0.678 rs560638 chr8:9882767 A/G cg16141378 chr3:129829833 LOC729375 0.42 6.26 0.33 1.19e-9 Neuroticism; CRC cis rs875971 0.619 rs10278371 chr7:66051540 C/A cg11764359 chr7:65958608 NA -0.56 -8.69 -0.43 1.68e-16 Aortic root size; CRC cis rs796364 0.806 rs10931887 chr2:200968905 G/A cg25936922 chr2:200820526 C2orf60;C2orf47 -0.66 -6.17 -0.32 2.02e-9 Schizophrenia; CRC trans rs35110281 0.744 rs230645 chr21:44918607 A/G cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO -0.39 -6.11 -0.32 2.81e-9 Mean corpuscular volume; CRC cis rs3806843 0.778 rs2531346 chr5:140126139 T/G cg19875535 chr5:140030758 IK -0.53 -8.35 -0.42 1.94e-15 Depressive symptoms (multi-trait analysis); CRC cis rs9311474 0.607 rs4687625 chr3:52563718 C/T cg18099408 chr3:52552593 STAB1 -0.52 -9.02 -0.45 1.57e-17 Electroencephalogram traits; CRC cis rs4660261 0.526 rs2485996 chr1:44354661 C/T cg12908607 chr1:44402522 ARTN -0.52 -9.52 -0.46 3.94e-19 Intelligence (multi-trait analysis); CRC cis rs7613875 0.600 rs2247510 chr3:50126215 A/C cg24110177 chr3:50126178 RBM5 -0.61 -9.5 -0.46 4.62e-19 Body mass index; CRC cis rs1891275 0.515 rs6583784 chr10:93491576 A/G cg07889827 chr10:93443413 NA 0.4 6.77 0.35 6.03e-11 Intelligence (multi-trait analysis); CRC cis rs12216125 0.549 rs9358905 chr6:26077839 T/A cg18357526 chr6:26021779 HIST1H4A 0.43 6.08 0.32 3.27e-9 Iron status biomarkers; CRC cis rs853679 0.517 rs4713145 chr6:28106827 T/C cg12273811 chr6:28175739 NA 0.73 9.36 0.46 1.34e-18 Depression; CRC cis rs6604026 0.656 rs2811598 chr1:93336933 A/G cg17283838 chr1:93427260 FAM69A -0.43 -5.6 -0.3 4.52e-8 Multiple sclerosis; CRC cis rs57677839 1 rs57677839 chr11:17028189 G/A cg03198203 chr11:17034484 PLEKHA7 -0.27 -6.59 -0.34 1.76e-10 Coronary artery disease; CRC cis rs523522 0.962 rs10849757 chr12:120964014 G/A cg27279351 chr12:120934652 DYNLL1 0.78 11.48 0.53 7.05e-26 High light scatter reticulocyte count; CRC cis rs10782582 0.593 rs115291524 chr1:76141811 A/G cg03433033 chr1:76189801 ACADM -0.43 -6.16 -0.32 2.1e-9 Daytime sleep phenotypes; CRC cis rs908922 0.676 rs549044 chr1:152514332 C/T cg09873164 chr1:152488093 CRCT1 0.38 6.33 0.33 7.97e-10 Hair morphology; CRC trans rs60843830 1.000 rs3791224 chr2:221981 C/T cg11347411 chr7:150020925 ACTR3C;LRRC61 0.59 9.06 0.45 1.18e-17 Spherical equivalent (joint analysis main effects and education interaction); CRC cis rs727505 1.000 rs68007199 chr7:124491307 T/C cg23710748 chr7:124431027 NA -0.85 -15.05 -0.64 2.48e-39 Lewy body disease; CRC cis rs73206853 0.841 rs73191825 chr12:110942205 T/C cg12870014 chr12:110450643 ANKRD13A 0.77 7.44 0.38 8.61e-13 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC cis rs1448094 0.740 rs4919774 chr12:86337560 G/T cg25456477 chr12:86230367 RASSF9 0.33 5.69 0.3 2.82e-8 Major depressive disorder; CRC trans rs11098499 1.000 rs6849889 chr4:120186348 A/C cg25214090 chr10:38739885 LOC399744 0.52 8.05 0.41 1.51e-14 Corneal astigmatism; CRC cis rs10540 1.000 rs12421457 chr11:505780 T/C cg03934478 chr11:495069 RNH1 0.69 7.77 0.39 9.92e-14 Body mass index; CRC cis rs896854 0.967 rs13257021 chr8:95965695 A/G cg13393036 chr8:95962371 TP53INP1 -0.55 -9.3 -0.46 2.08e-18 Type 2 diabetes; CRC cis rs1552244 0.816 rs13059144 chr3:10010197 A/C cg13047869 chr3:10149882 C3orf24 0.52 7.03 0.36 1.19e-11 Alzheimer's disease; CRC cis rs1707322 1.000 rs1768818 chr1:46514286 G/C cg06784218 chr1:46089804 CCDC17 -0.55 -9.74 -0.47 7.37e-20 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs394563 0.591 rs237035 chr6:149710848 C/T cg11245181 chr6:149772854 ZC3H12D -0.54 -9.41 -0.46 8.76e-19 Dupuytren's disease; CRC cis rs2749592 0.513 rs9417249 chr10:37837155 C/T cg00409905 chr10:38381863 ZNF37A 0.52 8.0 0.4 2.16e-14 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs1552244 0.938 rs9873794 chr3:10074153 T/G cg02579736 chr3:10068473 FANCD2;CIDECP 0.95 12.92 0.58 3.72e-31 Alzheimer's disease; CRC cis rs6840360 0.642 rs7676493 chr4:152426765 C/T cg09659197 chr4:152720779 NA 0.33 6.66 0.34 1.14e-10 Intelligence (multi-trait analysis); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg12504957 chr12:69202060 MDM2 0.43 6.12 0.32 2.73e-9 Intelligence (multi-trait analysis); CRC cis rs11785400 0.793 rs11543967 chr8:143739435 A/G cg10596483 chr8:143751796 JRK -0.42 -5.67 -0.3 3.1e-8 Schizophrenia; CRC trans rs8141529 0.507 rs5762936 chr22:29381377 A/G cg23715435 chr6:26027513 HIST1H4B 0.57 6.36 0.33 6.94e-10 Lymphocyte counts; CRC cis rs10782582 0.609 rs11588643 chr1:76255613 A/G cg03433033 chr1:76189801 ACADM -0.4 -5.78 -0.3 1.73e-8 Daytime sleep phenotypes; CRC cis rs6912958 0.535 rs1753153 chr6:88032834 T/G cg04972856 chr6:88032051 C6orf162;GJB7 0.33 6.08 0.32 3.35e-9 Monocyte percentage of white cells; CRC cis rs4664308 0.618 rs4665139 chr2:160890692 G/T cg03641300 chr2:160917029 PLA2R1 -0.55 -8.38 -0.42 1.55e-15 Idiopathic membranous nephropathy; CRC cis rs1044826 0.642 rs6799312 chr3:139211932 C/T cg00490450 chr3:139108681 COPB2 0.45 6.69 0.35 9.56e-11 Obesity-related traits; CRC trans rs4263408 0.934 rs9683743 chr4:39703194 A/C cg01575614 chr17:40169693 DNAJC7;NKIRAS2 -0.42 -6.13 -0.32 2.58e-9 Plasma amyloid beta peptide concentrations (ABx-40); CRC cis rs9325144 0.723 rs10161183 chr12:39182087 T/C cg26384229 chr12:38710491 ALG10B -0.44 -5.84 -0.31 1.27e-8 Morning vs. evening chronotype; CRC cis rs6570726 0.818 rs398812 chr6:145817271 T/C cg23711669 chr6:146136114 FBXO30 0.68 12.09 0.55 4.38e-28 Lobe attachment (rater-scored or self-reported); CRC cis rs72772090 0.539 rs10515247 chr5:96111726 G/A cg17330273 chr5:96107758 CAST;ERAP1 -0.65 -5.93 -0.31 7.5e-9 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs9487051 0.714 rs13209277 chr6:109624963 T/A cg21918786 chr6:109611834 NA -0.38 -6.87 -0.35 3.25e-11 Reticulocyte fraction of red cells; CRC cis rs72717009 0.825 rs7539468 chr1:161477066 G/A cg23840854 chr1:161414152 NA -0.67 -8.14 -0.41 8.07e-15 Rheumatoid arthritis; CRC cis rs7274811 0.779 rs13039908 chr20:32052070 G/A cg07470512 chr20:32255052 NECAB3;C20orf134 -0.43 -5.75 -0.3 2e-8 Height; CRC cis rs6584202 0.589 rs10883094 chr10:100188106 C/T cg26618903 chr10:100175079 PYROXD2 -0.43 -6.54 -0.34 2.34e-10 Obesity-related traits; CRC cis rs3540 0.512 rs17263706 chr15:91078803 G/T cg22089800 chr15:90895588 ZNF774 0.58 9.64 0.47 1.51e-19 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; CRC cis rs801193 0.967 rs2707841 chr7:66157020 A/G cg05627663 chr7:65219948 SNORA22;CCT6P1 0.42 6.13 0.32 2.46e-9 Aortic root size; CRC cis rs8072100 0.713 rs2292346 chr17:45455473 G/A cg25173405 chr17:45401733 C17orf57 -0.44 -6.56 -0.34 2.1e-10 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs950169 1.000 rs12915234 chr15:84758301 G/A cg03959625 chr15:84868606 LOC388152 0.41 6.07 0.32 3.55e-9 Schizophrenia; CRC cis rs4713118 0.513 rs156739 chr6:28013410 C/A cg10876282 chr6:28092338 ZSCAN16 0.49 6.62 0.34 1.5e-10 Parkinson's disease; CRC trans rs1126478 0.650 rs11130091 chr3:46504531 G/C cg23913400 chr17:73717552 ITGB4 0.47 6.05 0.32 3.89e-9 Blood protein levels; CRC cis rs736408 0.716 rs2300149 chr3:52822921 C/T cg05573699 chr3:52720067 GNL3;PBRM1 -0.46 -6.37 -0.33 6.19e-10 Bipolar disorder; CRC cis rs11105298 0.891 rs10858851 chr12:89830870 C/T cg00757033 chr12:89920650 WDR51B 0.35 5.81 0.31 1.46e-8 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; CRC cis rs12534701 1.000 rs12534701 chr7:154680910 A/C cg24255201 chr7:154684926 DPP6 -0.58 -8.46 -0.42 8.97e-16 Colorectal cancer (diet interaction); CRC cis rs3996993 0.809 rs2894802 chr6:52656169 T/G cg20803780 chr6:52668592 GSTA1 -0.38 -7.17 -0.37 5.05e-12 Hemoglobin concentration; CRC cis rs7312933 0.558 rs11181483 chr12:42798384 G/C cg19980929 chr12:42632907 YAF2 0.42 6.24 0.33 1.37e-9 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CRC cis rs12477438 0.501 rs12992218 chr2:99753834 G/A cg26064155 chr2:99771622 LIPT1;TSGA10 0.88 16.2 0.67 8.61e-44 Chronic sinus infection; CRC cis rs9296092 0.521 rs6929165 chr6:33515958 T/G cg13560919 chr6:33536144 NA -0.41 -5.79 -0.3 1.68e-8 Age at smoking initiation in chronic obstructive pulmonary disease; CRC cis rs9399135 0.967 rs9389256 chr6:135331254 A/C cg24558204 chr6:135376177 HBS1L 0.52 8.15 0.41 7.88e-15 Red blood cell count; CRC cis rs3091242 0.935 rs3093632 chr1:25684012 C/T cg20684491 chr1:25596433 NA 0.43 7.79 0.39 8.55e-14 Erythrocyte sedimentation rate; CRC cis rs7119 0.651 rs12904823 chr15:77837662 G/A cg27398640 chr15:77910606 LINGO1 -0.42 -7.14 -0.37 5.93e-12 Type 2 diabetes; CRC cis rs11792861 0.816 rs3763643 chr9:111695607 T/C cg05043794 chr9:111880884 C9orf5 -0.33 -5.77 -0.3 1.82e-8 Menarche (age at onset); CRC cis rs1728785 0.901 rs1170437 chr16:68607943 C/T cg02972257 chr16:68554789 NA -0.6 -7.28 -0.37 2.46e-12 Ulcerative colitis; CRC cis rs2735413 0.914 rs2707604 chr16:78054853 A/G cg04733911 chr16:78082701 NA -0.35 -5.69 -0.3 2.76e-8 Systolic blood pressure (alcohol consumption interaction); CRC cis rs250677 0.687 rs250672 chr5:148446110 A/G cg18129178 chr5:148520854 ABLIM3 -0.36 -5.64 -0.3 3.72e-8 Breast cancer; CRC cis rs2204008 0.515 rs11495471 chr12:38027178 G/A cg26384229 chr12:38710491 ALG10B 0.68 9.03 0.45 1.48e-17 Bladder cancer; CRC cis rs1707322 1.000 rs12403666 chr1:46431621 G/A cg06784218 chr1:46089804 CCDC17 0.51 9.02 0.45 1.55e-17 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs6496667 1.000 rs6496665 chr15:90891615 G/A cg04176472 chr15:90893244 GABARAPL3 0.55 8.43 0.42 1.09e-15 Rheumatoid arthritis; CRC cis rs6952808 1.000 rs4601204 chr7:1890925 C/T cg04267008 chr7:1944627 MAD1L1 -0.77 -11.02 -0.52 2.97e-24 Bipolar disorder and schizophrenia; CRC cis rs3820068 0.581 rs3940061 chr1:15941276 C/T cg24675056 chr1:15929824 NA 0.49 6.78 0.35 5.69e-11 Systolic blood pressure; CRC cis rs7843479 1.000 rs1032094 chr8:21820479 A/T cg17168535 chr8:21777572 XPO7 0.55 8.85 0.44 5.51e-17 Mean corpuscular volume; CRC cis rs644799 0.965 rs3789960 chr11:95509037 C/G cg25478527 chr11:95522999 CEP57;FAM76B 0.52 7.75 0.39 1.15e-13 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs7192380 0.893 rs1469908 chr16:69764412 C/T cg00738113 chr16:70207722 CLEC18C 0.33 5.77 0.3 1.79e-8 Sjögren's syndrome; CRC cis rs1559088 0.895 rs7246562 chr19:33546088 T/G cg27124370 chr19:33622961 WDR88 0.41 5.68 0.3 2.94e-8 Bone ultrasound measurement (broadband ultrasound attenuation); CRC cis rs7618501 1.000 rs3811696 chr3:49761605 C/T cg24308560 chr3:49941425 MST1R 0.45 7.16 0.37 5.47e-12 Intelligence (multi-trait analysis); CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg18097281 chr15:40545145 PAK6;C15orf56 0.44 5.99 0.31 5.55e-9 Anxiety disorder; CRC cis rs2952156 0.883 rs2941505 chr17:37832704 A/G cg11212589 chr17:38028394 ZPBP2 0.35 6.25 0.33 1.24e-9 Asthma; CRC cis rs4713118 0.621 rs4713134 chr6:28034121 T/C cg06470822 chr6:28175283 NA 0.94 12.8 0.58 1.0500000000000001e-30 Parkinson's disease; CRC cis rs2842992 0.724 rs9347340 chr6:160188891 C/T cg11366901 chr6:160182831 ACAT2 -0.74 -11.12 -0.52 1.33e-24 Age-related macular degeneration (geographic atrophy); CRC cis rs2898681 0.521 rs115874483 chr4:53728272 G/A cg26260408 chr4:53727979 RASL11B 0.41 5.92 0.31 8.2e-9 Optic nerve measurement (cup area); CRC trans rs3960554 0.529 rs7793844 chr7:75883147 C/T cg19862616 chr7:65841803 NCRNA00174 0.48 6.79 0.35 5.11e-11 Eotaxin levels; CRC cis rs9443645 0.775 rs9359359 chr6:79700980 T/C cg09184832 chr6:79620586 NA -0.49 -8.72 -0.43 1.36e-16 Intelligence (multi-trait analysis); CRC cis rs17345786 0.511 rs12639028 chr3:101346033 G/C cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.66 8.81 0.44 7.07e-17 Colonoscopy-negative controls vs population controls; CRC cis rs2304069 0.954 rs1469691 chr5:149386716 G/A cg22760475 chr5:149380129 HMGXB3;TIGD6 0.89 10.1 0.49 4.65e-21 HIV-1 control; CRC cis rs3892630 0.824 rs35654350 chr19:33223766 T/C cg22980127 chr19:33182716 NUDT19 0.91 10.87 0.51 9.82e-24 Red blood cell traits; CRC cis rs897984 0.542 rs3751855 chr16:31091209 T/C cg00531865 chr16:30841666 NA -0.42 -6.09 -0.32 3.15e-9 Dementia with Lewy bodies; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg02073511 chr16:3550924 CLUAP1 -0.4 -6.21 -0.32 1.64e-9 Myopia (pathological); CRC trans rs360798 0.512 rs34104251 chr2:62995183 A/G cg05376469 chr2:102649931 NA 0.39 6.3 0.33 9.63e-10 Coronary artery disease; CRC cis rs10504229 1.000 rs17805656 chr8:58180318 T/C cg01721255 chr8:58191610 C8orf71 0.49 6.17 0.32 2e-9 Developmental language disorder (linguistic errors); CRC cis rs7520050 0.645 rs1768809 chr1:46502836 A/C cg06784218 chr1:46089804 CCDC17 -0.35 -6.47 -0.34 3.5e-10 Red blood cell count;Reticulocyte count; CRC trans rs113835537 0.627 rs4630309 chr11:66333072 A/C cg05679836 chr12:57472765 TMEM194A 0.58 6.01 0.31 5.05e-9 Airway imaging phenotypes; CRC cis rs1799949 1.000 rs11649954 chr17:41420035 A/G cg01879757 chr17:41196368 BRCA1 -0.43 -6.63 -0.34 1.39e-10 Menopause (age at onset); CRC cis rs6585424 1.000 rs61860045 chr10:81947397 C/T cg05935833 chr10:81318306 SFTPA2 -0.47 -5.64 -0.3 3.6e-8 Chronic obstructive pulmonary disease-related biomarkers; CRC trans rs12599106 0.660 rs12919333 chr16:34991336 C/T cg21548813 chr6:291882 DUSP22 -0.68 -9.72 -0.47 8.49e-20 Menopause (age at onset); CRC cis rs1048238 0.846 rs945422 chr1:16345619 T/C cg10494257 chr1:16342123 HSPB7 0.41 5.74 0.3 2.16e-8 Systolic blood pressure; CRC cis rs2380220 0.541 rs72928277 chr6:96079745 G/T cg15832292 chr6:96025679 MANEA -0.6 -6.35 -0.33 7.11e-10 Behavioural disinhibition (generation interaction); CRC cis rs7666738 0.830 rs60411337 chr4:99046617 T/C cg17366294 chr4:99064904 C4orf37 0.45 7.71 0.39 1.47e-13 Colonoscopy-negative controls vs population controls; CRC cis rs3812049 0.737 rs1993878 chr5:127476971 C/A cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.71 8.9 0.44 3.81e-17 Lymphocyte counts;Red cell distribution width; CRC cis rs17345786 0.861 rs11711808 chr3:101235101 T/C cg12386194 chr3:101231763 SENP7 0.56 7.29 0.37 2.27e-12 Colonoscopy-negative controls vs population controls; CRC cis rs17092148 0.887 rs2378199 chr20:33186480 T/C cg08999081 chr20:33150536 PIGU 0.51 6.41 0.33 5.13e-10 Neuroticism; CRC cis rs13108904 0.934 rs13125338 chr4:1278435 A/C cg16405210 chr4:1374714 KIAA1530 -0.46 -6.34 -0.33 7.54e-10 Obesity-related traits; CRC cis rs34172651 0.517 rs2303083 chr16:24835168 G/A cg06028605 chr16:24865363 SLC5A11 0.53 7.72 0.39 1.43e-13 Intelligence (multi-trait analysis); CRC cis rs7208859 0.623 rs73269913 chr17:29092183 T/C cg13385521 chr17:29058706 SUZ12P 0.74 8.45 0.42 9.82e-16 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs763121 0.925 rs1056661 chr22:39080245 A/G cg06022373 chr22:39101656 GTPBP1 0.73 12.14 0.56 2.76e-28 Menopause (age at onset); CRC cis rs9902453 0.967 rs4493117 chr17:28489770 G/A cg26525008 chr17:28256777 EFCAB5;SSH2 0.68 11.09 0.52 1.78e-24 Coffee consumption (cups per day); CRC cis rs3785574 1.000 rs3785574 chr17:61763185 T/C cg23090583 chr17:61904693 PSMC5;FTSJ3 0.59 8.08 0.41 1.23e-14 Height; CRC cis rs1256061 0.646 rs1152588 chr14:64688175 G/C cg23250157 chr14:64679961 SYNE2 0.44 6.93 0.36 2.28e-11 Hemoglobin concentration;Red blood cell count;Hematocrit; CRC trans rs2727020 0.553 rs7479975 chr11:49581964 C/G cg15704280 chr7:45808275 SEPT13 -0.96 -17.97 -0.7 9.06e-51 Coronary artery disease; CRC cis rs9462027 0.675 rs9296132 chr6:34777531 T/G cg07306190 chr6:34760872 UHRF1BP1 -0.34 -5.93 -0.31 7.48e-9 Systemic lupus erythematosus; CRC cis rs1580019 0.922 rs1376289 chr7:32486980 C/G cg07520158 chr7:32535189 LSM5;AVL9 -0.48 -6.36 -0.33 6.9e-10 Cognitive ability; CRC cis rs4689592 0.513 rs2358718 chr4:7068743 A/C cg26116260 chr4:7069785 GRPEL1 -0.97 -14.57 -0.63 1.9e-37 Monocyte percentage of white cells; CRC cis rs2153535 0.580 rs6421949 chr6:8531769 G/A cg07606381 chr6:8435919 SLC35B3 0.66 10.8 0.51 1.79e-23 Motion sickness; CRC cis rs6968419 0.755 rs4730719 chr7:115895010 A/C cg02561103 chr7:115862891 TES 0.44 6.66 0.34 1.18e-10 Intraocular pressure; CRC cis rs270601 0.710 rs371709 chr5:131583240 A/G cg11843238 chr5:131593191 PDLIM4 0.52 9.21 0.45 4.05e-18 Acylcarnitine levels; CRC cis rs2760061 0.819 rs964941 chr1:228193857 G/A cg18477163 chr1:228402036 OBSCN 0.44 7.4 0.38 1.12e-12 Diastolic blood pressure; CRC cis rs10751667 0.666 rs7105477 chr11:964271 C/G cg23136738 chr11:925521 AP2A2 -0.42 -6.92 -0.36 2.4e-11 Alzheimer's disease (late onset); CRC cis rs7811142 1.000 rs60478351 chr7:100089017 C/T cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.08 15.21 0.64 6.34e-40 Platelet count; CRC cis rs847649 0.767 rs11972261 chr7:102641244 T/G cg18108683 chr7:102477205 FBXL13 0.56 8.97 0.44 2.3e-17 Morning vs. evening chronotype; CRC cis rs2576037 0.542 rs4630643 chr18:44508142 G/A cg19077165 chr18:44547161 KATNAL2 -0.68 -11.01 -0.52 3.15e-24 Personality dimensions; CRC cis rs116095464 0.558 rs60251075 chr5:245292 T/C cg22857025 chr5:266934 NA -1.25 -16.72 -0.68 7.27e-46 Breast cancer; CRC cis rs9914988 1.000 rs9916866 chr17:27183155 C/G cg12682573 chr17:27188876 MIR451;MIR144 -0.6 -8.79 -0.44 8.51e-17 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs1451375 0.617 rs2329371 chr7:50615440 G/A cg18232548 chr7:50535776 DDC 0.47 6.15 0.32 2.2e-9 Malaria; CRC cis rs2735413 0.875 rs12923229 chr16:78080302 C/A cg04733911 chr16:78082701 NA -0.44 -7.37 -0.38 1.38e-12 Systolic blood pressure (alcohol consumption interaction); CRC cis rs6500395 0.963 rs961951 chr16:48716720 A/G cg04672837 chr16:48644449 N4BP1 -0.45 -6.7 -0.35 9.21e-11 Response to tocilizumab in rheumatoid arthritis; CRC trans rs11039798 1.000 rs7928243 chr11:48589192 A/T cg15704280 chr7:45808275 SEPT13 0.64 6.27 0.33 1.16e-9 Axial length; CRC trans rs10982213 0.830 rs2274163 chr9:117188714 C/T cg23943013 chr5:79551904 SERINC5 0.38 5.99 0.31 5.61e-9 Interleukin-6 levels; CRC cis rs2070488 0.775 rs6599211 chr3:38558830 A/G cg01465620 chr3:38496096 LOC100128640;ACVR2B -0.74 -12.44 -0.57 2.29e-29 Electrocardiographic conduction measures; CRC cis rs2075671 0.903 rs11979818 chr7:100293639 A/G cg20848291 chr7:100343083 ZAN 0.69 10.25 0.49 1.36e-21 Other erythrocyte phenotypes; CRC cis rs7811142 1.000 rs7803454 chr7:99991548 C/T cg00814883 chr7:100076585 TSC22D4 -0.78 -9.37 -0.46 1.15e-18 Platelet count; CRC cis rs9467603 1.000 rs9467609 chr6:25809751 A/G cg16898833 chr6:26189333 HIST1H4D 0.77 6.45 0.33 4.07e-10 Intelligence (multi-trait analysis); CRC cis rs1046896 1.000 rs1046896 chr17:80685533 A/G cg16060761 chr17:80687452 NA 0.54 8.34 0.42 2.06e-15 Glycated hemoglobin levels; CRC cis rs2120019 0.935 rs8042409 chr15:75350433 G/A cg17294928 chr15:75287854 SCAMP5 -0.77 -11.22 -0.53 5.99e-25 Blood trace element (Zn levels); CRC cis rs11249608 0.744 rs4701025 chr5:178444474 G/A cg01312482 chr5:178451176 ZNF879 0.36 6.27 0.33 1.16e-9 Pubertal anthropometrics; CRC cis rs13256369 0.708 rs10903310 chr8:8589687 A/C cg06636001 chr8:8085503 FLJ10661 -0.44 -5.65 -0.3 3.48e-8 Obesity-related traits; CRC cis rs4972806 0.668 rs2072588 chr2:177042930 G/C cg10305451 chr2:177043427 NA 0.72 11.31 0.53 2.76e-25 IgG glycosylation; CRC cis rs17253792 0.822 rs77741349 chr14:56097462 C/T cg01858014 chr14:56050164 KTN1 -0.87 -7.23 -0.37 3.34e-12 Putamen volume; CRC cis rs924607 1.000 rs4045344 chr5:595870 G/T cg09021430 chr5:549028 NA 0.53 9.0 0.44 1.82e-17 Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia; CRC cis rs10464366 0.544 rs6952466 chr7:39155032 A/T cg21665744 chr7:39171113 POU6F2 0.45 6.13 0.32 2.54e-9 IgG glycosylation; CRC cis rs11148252 0.967 rs11620062 chr13:52994026 T/G cg12458913 chr13:53173898 NA 0.55 8.69 0.43 1.69e-16 Lewy body disease; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg15344021 chr17:2240169 TSR1;SGSM2 0.51 6.71 0.35 8.43e-11 Thyroid stimulating hormone; CRC cis rs7617773 0.963 rs12493256 chr3:48176747 C/T cg11946769 chr3:48343235 NME6 -0.45 -6.29 -0.33 9.93e-10 Coronary artery disease; CRC cis rs7618915 0.547 rs3774365 chr3:52642487 T/C cg11645453 chr3:52864694 ITIH4 0.35 6.09 0.32 3.17e-9 Bipolar disorder; CRC cis rs720844 0.748 rs10928407 chr2:149329961 C/G cg09247360 chr2:149335327 NA -0.56 -5.86 -0.31 1.09e-8 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs11229555 0.645 rs4347409 chr11:58176252 C/T cg15696309 chr11:58395628 NA 0.8 10.3 0.49 9.25e-22 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg20566420 chr12:122327043 PSMD9 0.51 6.62 0.34 1.42e-10 Thyroid stimulating hormone; CRC cis rs611744 0.625 rs11991891 chr8:109294858 G/A cg18478394 chr8:109455254 TTC35 0.41 6.18 0.32 1.88e-9 Dupuytren's disease; CRC cis rs9329221 0.527 rs7833781 chr8:10333477 A/G cg27411982 chr8:10470053 RP1L1 0.39 6.16 0.32 2.09e-9 Neuroticism; CRC cis rs2346177 0.580 rs7565770 chr2:46683683 A/C cg02822958 chr2:46747628 ATP6V1E2 0.43 6.96 0.36 1.85e-11 HDL cholesterol; CRC cis rs7178572 0.633 rs4886876 chr15:77838491 C/T cg22256960 chr15:77711686 NA -0.64 -9.26 -0.45 2.65e-18 Type 2 diabetes; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg04361527 chr1:154909836 PMVK 0.43 6.1 0.32 3.05e-9 Intelligence (multi-trait analysis); CRC cis rs853679 0.542 rs6934769 chr6:28090931 A/G cg02683197 chr6:28174875 NA 0.85 10.52 0.5 1.71e-22 Depression; CRC trans rs58688157 0.705 rs7928902 chr11:609068 G/A cg19188899 chr13:112838565 NA -0.43 -6.75 -0.35 6.79e-11 Systemic lupus erythematosus; CRC cis rs7618915 0.547 rs34017441 chr3:52742413 T/C cg11645453 chr3:52864694 ITIH4 0.34 5.9 0.31 9.11e-9 Bipolar disorder; CRC cis rs11864453 0.713 rs9926156 chr16:72142895 G/C cg01557791 chr16:72042693 DHODH -0.44 -6.15 -0.32 2.28e-9 Fibrinogen levels; CRC cis rs2816062 0.813 rs2816040 chr1:18889536 C/T cg18795169 chr1:18902165 NA 0.9 18.72 0.72 9.17e-54 Urate levels in lean individuals; CRC cis rs10992471 0.603 rs1980848 chr9:95248571 A/G cg14631576 chr9:95140430 CENPP 0.41 7.22 0.37 3.55e-12 Visceral adipose tissue/subcutaneous adipose tissue ratio; CRC trans rs66887589 0.807 rs9799664 chr4:120326678 C/T cg25214090 chr10:38739885 LOC399744 0.42 6.56 0.34 2.03e-10 Diastolic blood pressure; CRC cis rs561341 0.941 rs8066558 chr17:30272879 G/T cg00745463 chr17:30367425 LRRC37B -0.7 -8.48 -0.42 7.49e-16 Hip circumference adjusted for BMI; CRC cis rs1800469 1.000 rs2317130 chr19:41861674 C/T cg09537434 chr19:41945824 ATP5SL -0.49 -6.33 -0.33 8.03e-10 Colorectal cancer; CRC cis rs7493 1.000 rs3779492 chr7:95044183 C/T cg19678392 chr7:94953810 PON1 -0.56 -7.06 -0.36 9.89e-12 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs67981189 0.529 rs2810097 chr14:71434114 C/T cg15910301 chr14:71632612 NA -0.29 -5.68 -0.3 2.89e-8 Schizophrenia; CRC cis rs7618915 0.571 rs6798246 chr3:52599922 G/A cg15147215 chr3:52552868 STAB1 -0.63 -10.56 -0.5 1.22e-22 Bipolar disorder; CRC cis rs9910055 0.762 rs2526021 chr17:42213347 G/A cg09913183 chr17:42254507 C17orf65;ASB16 0.58 8.45 0.42 9.38e-16 Total body bone mineral density; CRC cis rs1552244 0.882 rs56332224 chr3:10037321 G/A cg08888203 chr3:10149979 C3orf24 0.65 8.74 0.43 1.2e-16 Alzheimer's disease; CRC cis rs1448094 0.817 rs7973694 chr12:86335589 A/G cg25456477 chr12:86230367 RASSF9 0.35 5.97 0.31 6.11e-9 Major depressive disorder; CRC cis rs7829975 0.871 rs572307 chr8:8578811 T/C cg08975724 chr8:8085496 FLJ10661 -0.44 -6.77 -0.35 6.04e-11 Mood instability; CRC cis rs2242116 0.592 rs6442039 chr3:46960797 C/G cg27129171 chr3:47204927 SETD2 0.55 6.73 0.35 7.57e-11 Birth weight; CRC cis rs4332037 0.539 rs11762636 chr7:2061111 C/A cg25834613 chr7:1915315 MAD1L1 -0.41 -5.89 -0.31 9.69e-9 Bipolar disorder; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg00597366 chr16:46917883 GPT2 0.48 6.71 0.35 8.74e-11 Response to antipsychotic treatment; CRC cis rs763121 0.853 rs1065201 chr22:39069510 T/C cg06022373 chr22:39101656 GTPBP1 0.8 12.62 0.57 4.84e-30 Menopause (age at onset); CRC cis rs34172651 0.606 rs7194189 chr16:24703484 G/T cg06028605 chr16:24865363 SLC5A11 -0.42 -6.53 -0.34 2.43e-10 Intelligence (multi-trait analysis); CRC trans rs7859245 1.000 rs7859245 chr9:138490597 A/G cg05843800 chr3:4508875 SUMF1 -0.39 -6.13 -0.32 2.56e-9 Response to paliperidone in schizophrenia (negative Marder score); CRC trans rs6956675 0.534 rs7780975 chr7:62652443 G/A cg01314568 chr7:57830625 NA -0.43 -6.31 -0.33 9.04e-10 Obesity-related traits; CRC cis rs76878669 0.561 rs7115577 chr11:66172258 G/T cg24851651 chr11:66362959 CCS 0.38 6.43 0.33 4.56e-10 Educational attainment (years of education); CRC cis rs4665630 0.522 rs114382704 chr2:23951810 G/T cg07265300 chr2:24346000 PFN4;LOC375190 0.78 5.91 0.31 8.42e-9 Hypertension; CRC cis rs919433 1.000 rs1560277 chr2:198187903 C/T cg10820045 chr2:198174542 NA 0.46 7.83 0.4 6.65e-14 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC cis rs245880 0.740 rs245902 chr7:29194919 T/A cg17163760 chr7:29186267 CPVL -0.39 -6.88 -0.35 3.05e-11 Warfarin maintenance dose; CRC cis rs2739330 0.760 rs1002286 chr22:24257337 A/G cg24846343 chr22:24311635 DDTL -0.74 -12.79 -0.58 1.07e-30 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs910316 1.000 rs7303 chr14:75520065 T/C cg03030879 chr14:75389066 RPS6KL1 -0.46 -7.14 -0.37 6.14e-12 Height; CRC cis rs3771570 0.901 rs869943 chr2:242431585 C/G cg21155796 chr2:242212141 HDLBP 0.63 6.8 0.35 5.04e-11 Prostate cancer; CRC cis rs1044826 0.642 rs186103 chr3:139211942 C/A cg00490450 chr3:139108681 COPB2 0.44 6.52 0.34 2.64e-10 Obesity-related traits; CRC cis rs6484504 0.600 rs942272 chr11:31364368 C/T cg14844989 chr11:31128820 NA 0.35 6.07 0.32 3.58e-9 Red blood cell count; CRC cis rs7103648 0.808 rs7103835 chr11:47461693 G/A cg20307385 chr11:47447363 PSMC3 0.88 13.01 0.58 1.73e-31 Diastolic blood pressure;Systolic blood pressure; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg07251136 chr5:95158433 GLRX 0.45 6.29 0.33 1.03e-9 Response to antipsychotic treatment; CRC cis rs6547741 1.000 rs76784350 chr2:27764278 A/G cg27432699 chr2:27873401 GPN1 0.76 13.35 0.59 9.06e-33 Oral cavity cancer; CRC cis rs2732480 0.577 rs2732448 chr12:48730600 T/C cg24011408 chr12:48396354 COL2A1 0.45 6.1 0.32 3.01e-9 Hemoglobin concentration;Red blood cell count;Hematocrit; CRC cis rs4862750 0.872 rs9997374 chr4:187877549 T/A cg06074448 chr4:187884817 NA -0.59 -10.97 -0.52 4.48e-24 Lobe attachment (rater-scored or self-reported); CRC trans rs9388451 0.839 rs9401845 chr6:126104118 A/G cg05039488 chr6:79577232 IRAK1BP1 -0.55 -8.28 -0.42 3.05e-15 Brugada syndrome; CRC cis rs7191439 0.858 rs8050715 chr16:88780923 C/G cg27087555 chr16:88793112 FAM38A -1.33 -12.9 -0.58 4.5e-31 Plateletcrit; CRC cis rs6840360 0.530 rs12645029 chr4:152650032 T/C cg09659197 chr4:152720779 NA 0.35 6.18 0.32 1.91e-9 Intelligence (multi-trait analysis); CRC cis rs769267 0.930 rs4808964 chr19:19603692 A/C cg02546618 chr19:19431379 KIAA0892;SF4 -0.43 -5.92 -0.31 7.92e-9 Tonsillectomy; CRC cis rs2180341 1.000 rs2057223 chr6:127637374 T/C cg27446573 chr6:127587934 RNF146 0.98 14.41 0.62 7.96e-37 Breast cancer; CRC cis rs3785574 0.962 rs56295011 chr17:61850359 A/G cg11494091 chr17:61959527 GH2 0.38 5.93 0.31 7.85e-9 Height; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg19940975 chr18:32820997 ZNF397 0.41 6.88 0.35 3.05e-11 Liver disease severity in Alagille syndrome; CRC cis rs6502050 0.835 rs67634087 chr17:80118168 C/T cg19223190 chr17:80058835 NA 0.41 6.52 0.34 2.58e-10 Life satisfaction; CRC cis rs1862618 0.573 rs1550821 chr5:56242323 C/T cg03609598 chr5:56110824 MAP3K1 0.74 8.84 0.44 5.96e-17 Initial pursuit acceleration; CRC cis rs12936587 0.748 rs11871738 chr17:17525243 A/G cg09796270 chr17:17721594 SREBF1 -0.41 -5.96 -0.31 6.44e-9 Hip circumference;Coronary artery disease or large artery stroke;Coronary heart disease;Coronary artery disease; CRC cis rs2836974 0.899 rs34433511 chr21:40618883 A/C cg11890956 chr21:40555474 PSMG1 1.11 19.13 0.73 2.31e-55 Cognitive function; CRC cis rs1865760 1.000 rs9393675 chr6:25930116 G/A cg17691542 chr6:26056736 HIST1H1C 0.55 7.98 0.4 2.49e-14 Height; CRC cis rs9611565 0.532 rs202627 chr22:41847367 A/T cg06481639 chr22:41940642 POLR3H 0.47 5.82 0.31 1.42e-8 Vitiligo; CRC cis rs950169 0.922 rs4842939 chr15:84827966 C/T cg11189052 chr15:85197271 WDR73 -0.57 -7.77 -0.39 9.98e-14 Schizophrenia; CRC cis rs4253772 0.637 rs9627402 chr22:46702586 C/T cg24881330 chr22:46731750 TRMU 0.59 6.4 0.33 5.3e-10 LDL cholesterol;Cholesterol, total; CRC trans rs561341 1.000 rs501312 chr17:30329066 A/G cg20587970 chr11:113659929 NA -1.42 -20.26 -0.75 8.39e-60 Hip circumference adjusted for BMI; CRC cis rs2067615 0.579 rs1811458 chr12:107203683 G/A cg13491945 chr12:107078410 RFX4 0.36 6.11 0.32 2.77e-9 Heart rate; CRC cis rs7552404 0.961 rs17587071 chr1:76225083 A/C cg03433033 chr1:76189801 ACADM 0.81 11.14 0.52 1.09e-24 Blood metabolite levels;Acylcarnitine levels; CRC trans rs7618501 1.000 rs11130219 chr3:49752427 C/T cg21665057 chr3:196295764 WDR53;FBXO45 -0.86 -16.05 -0.66 3.08e-43 Intelligence (multi-trait analysis); CRC cis rs2832191 0.791 rs2832197 chr21:30497790 T/C cg24692254 chr21:30365293 RNF160 -0.67 -11.39 -0.53 1.41e-25 Dental caries; CRC cis rs6860806 0.507 rs183898 chr5:131716902 C/G cg22638593 chr5:131593259 PDLIM4 -0.39 -6.37 -0.33 6.43e-10 Breast cancer; CRC cis rs4713118 0.662 rs4713120 chr6:27721835 C/A cg03623178 chr6:28175578 NA 0.59 8.47 0.42 8.46e-16 Parkinson's disease; CRC cis rs1448094 0.512 rs7313278 chr12:86250263 C/T cg02569458 chr12:86230093 RASSF9 0.43 7.41 0.38 1.06e-12 Major depressive disorder; CRC cis rs909002 0.800 rs3134718 chr1:32089839 C/T cg01639898 chr1:32083012 HCRTR1 0.3 6.13 0.32 2.49e-9 Intelligence (multi-trait analysis); CRC cis rs6500602 0.673 rs1861652 chr16:4505331 C/T cg08645402 chr16:4508243 NA 0.57 9.16 0.45 5.83e-18 Schizophrenia; CRC cis rs9322193 1.000 rs9377229 chr6:149928791 C/T cg05861140 chr6:150128134 PCMT1 -0.42 -6.85 -0.35 3.63e-11 Lung cancer; CRC cis rs6964587 0.967 rs7783414 chr7:91785957 C/T cg17063962 chr7:91808500 NA 0.86 15.4 0.65 1.17e-40 Breast cancer; CRC cis rs10242455 0.557 rs77997620 chr7:99070415 G/T cg18809830 chr7:99032528 PTCD1 -1.18 -8.59 -0.43 3.66e-16 Blood metabolite levels; CRC cis rs9457247 0.602 rs10484530 chr6:167461562 C/T cg07741184 chr6:167504864 NA 0.44 7.46 0.38 7.96e-13 Crohn's disease; CRC cis rs4713118 0.824 rs7759217 chr6:27730463 A/G cg12273811 chr6:28175739 NA 0.5 6.72 0.35 8.08e-11 Parkinson's disease; CRC cis rs763014 0.932 rs2384972 chr16:674424 G/A cg00802000 chr16:706648 WDR90 -0.44 -6.34 -0.33 7.61e-10 Height; CRC cis rs7727544 0.716 rs72793283 chr5:131566941 G/A cg12564285 chr5:131593104 PDLIM4 0.4 7.52 0.38 5.2e-13 Blood metabolite levels; CRC cis rs9322193 0.923 rs9800806 chr6:150061486 G/T cg00933542 chr6:150070202 PCMT1 0.34 7.04 0.36 1.12e-11 Lung cancer; CRC cis rs7666738 0.830 rs13124904 chr4:98856973 T/C cg17366294 chr4:99064904 C4orf37 0.41 6.67 0.35 1.08e-10 Colonoscopy-negative controls vs population controls; CRC trans rs66573146 1.000 rs6838250 chr4:6973184 C/G cg07817883 chr1:32538562 TMEM39B 1.5 13.63 0.6 7.37e-34 Granulocyte percentage of myeloid white cells; CRC cis rs6598955 0.724 rs4659420 chr1:26614333 G/A cg04990556 chr1:26633338 UBXN11 -0.77 -12.88 -0.58 5.23e-31 Obesity-related traits; CRC cis rs11155671 0.530 rs6939761 chr6:150210994 T/C cg07701084 chr6:150067640 NUP43 0.49 7.2 0.37 4.04e-12 Testicular germ cell tumor; CRC trans rs57221529 0.766 rs12519763 chr5:559145 C/T cg11887960 chr12:57824829 NA 0.58 6.44 0.33 4.17e-10 Lung disease severity in cystic fibrosis; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg03811519 chr9:134001305 NUP214 0.48 6.83 0.35 4.19e-11 Response to antipsychotic treatment; CRC cis rs8060686 0.668 rs12448991 chr16:68218894 T/A cg26727032 chr16:67993705 SLC12A4 -0.56 -6.51 -0.34 2.75e-10 HDL cholesterol;Metabolic syndrome; CRC cis rs769267 0.965 rs2074550 chr19:19387743 A/C cg20644253 chr19:19431407 KIAA0892;SF4 0.43 5.91 0.31 8.39e-9 Tonsillectomy; CRC cis rs1163251 0.902 rs639761 chr1:120217558 G/A cg19096424 chr1:120255104 PHGDH 0.46 6.65 0.34 1.2e-10 Blood metabolite levels; CRC cis rs6570726 0.875 rs12524077 chr6:145866333 G/C cg05347473 chr6:146136440 FBXO30 0.38 6.1 0.32 3.02e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs10782582 0.593 rs11589276 chr1:76105545 G/A cg10523679 chr1:76189770 ACADM -0.41 -5.83 -0.31 1.3e-8 Daytime sleep phenotypes; CRC trans rs2303319 0.504 rs12470590 chr2:162493102 A/G cg16721101 chr20:25176146 ENTPD6 -0.7 -6.09 -0.32 3.23e-9 Cognitive function; CRC cis rs853679 0.517 rs2273564 chr6:28057594 A/T cg12172441 chr6:28176163 NA 0.62 7.38 0.38 1.28e-12 Depression; CRC cis rs7945705 0.818 rs2742537 chr11:8908389 G/A cg00186954 chr11:8933980 ST5;C11orf17 -0.49 -8.33 -0.42 2.22e-15 Hemoglobin concentration; CRC cis rs1153858 1.000 rs4775909 chr15:45643042 T/C cg14582100 chr15:45693742 SPATA5L1 0.28 5.85 0.31 1.19e-8 Homoarginine levels; CRC cis rs4253311 0.520 rs10000459 chr4:187124459 A/C cg24794857 chr4:187113578 CYP4V2 0.4 5.95 0.31 6.98e-9 Plasma renin activity levels;Circulating chromogranin peptide levels;Blood metabolite levels; CRC cis rs9362426 0.708 rs4707367 chr6:88101188 A/C cg08069147 chr6:88032118 GJB7;C6orf162 -0.48 -6.3 -0.33 9.75e-10 Depressive episodes in bipolar disorder; CRC cis rs3760982 1.000 rs11665924 chr19:44286982 G/A cg21496419 chr19:44306685 LYPD5 0.35 6.5 0.34 3.02e-10 Breast cancer (estrogen-receptor negative);Breast cancer; CRC cis rs506338 0.517 rs490192 chr11:64471369 C/T cg06522879 chr11:64358276 SLC22A12 0.41 5.89 0.31 9.6e-9 Body mass index;Urate levels; CRC cis rs7727544 0.716 rs4705928 chr5:131578637 A/G cg04518342 chr5:131593106 PDLIM4 -0.36 -6.48 -0.34 3.43e-10 Blood metabolite levels; CRC cis rs1552244 1.000 rs7622966 chr3:10139833 C/T cg02579736 chr3:10068473 FANCD2;CIDECP 0.92 12.66 0.57 3.43e-30 Alzheimer's disease; CRC cis rs1129187 0.755 rs3293 chr6:42938377 G/T cg26304593 chr6:42947056 PEX6 -0.45 -6.56 -0.34 2.09e-10 Alzheimer's disease in APOE e4+ carriers; CRC trans rs4263408 0.934 rs9683743 chr4:39703194 A/C cg09252805 chr1:22778600 ZBTB40 -0.4 -6.03 -0.32 4.29e-9 Plasma amyloid beta peptide concentrations (ABx-40); CRC cis rs4588572 0.570 rs6453389 chr5:77727003 T/G cg11446398 chr5:77624930 NA 0.41 5.93 0.31 7.48e-9 Triglycerides; CRC trans rs1814175 0.791 rs11040513 chr11:49778153 G/C cg21153622 chr11:89784906 NA -0.37 -5.98 -0.31 5.8e-9 Height; CRC cis rs3096299 0.559 rs9931073 chr16:89568513 G/C cg00750074 chr16:89608354 SPG7 -0.47 -7.11 -0.36 7.4e-12 Multiple myeloma (IgH translocation); CRC cis rs60871478 0.588 rs56205589 chr7:910419 G/A cg13844804 chr7:814759 HEATR2 -0.53 -5.61 -0.3 4.37e-8 Cerebrospinal P-tau181p levels; CRC cis rs4332037 0.615 rs62435127 chr7:1884937 A/G cg13880726 chr7:1868755 MAD1L1 -0.43 -5.71 -0.3 2.52e-8 Bipolar disorder; CRC cis rs78456975 0.506 rs10167704 chr2:1571037 G/C cg26248373 chr2:1572462 NA -0.85 -12.51 -0.57 1.18e-29 Placebo response in major depressive disorder (% change in symptom score); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg15576692 chr20:18548019 LOC388789 0.36 6.15 0.32 2.28e-9 Liver disease severity in Alagille syndrome; CRC cis rs3733585 0.673 rs9994266 chr4:9954450 C/T cg11266682 chr4:10021025 SLC2A9 -0.45 -9.07 -0.45 1.08e-17 Cleft plate (environmental tobacco smoke interaction); CRC cis rs929354 0.742 rs1182396 chr7:157031831 A/C cg17757837 chr7:157058334 UBE3C -0.76 -13.15 -0.59 4.88e-32 Body mass index; CRC trans rs7580658 0.614 rs7585198 chr2:127962635 C/T cg00167275 chr10:88854588 FAM35A;GLUD1 -0.41 -6.0 -0.31 5.22e-9 Protein C levels; CRC cis rs4713118 0.629 rs149899 chr6:28019979 C/T cg18032046 chr6:28092343 ZSCAN16 -0.47 -6.07 -0.32 3.49e-9 Parkinson's disease; CRC cis rs9896933 0.775 rs615630 chr17:80730527 T/C cg20578329 chr17:80767326 TBCD 0.84 9.59 0.47 2.33e-19 Bone mineral accretion in asthma (oral corticosteroid dose interaction); CRC cis rs4713118 0.824 rs9366702 chr6:27734470 T/C cg15845792 chr6:28175446 NA 0.67 8.78 0.44 8.82e-17 Parkinson's disease; CRC cis rs6732160 0.588 rs2043100 chr2:73374096 T/C cg01422370 chr2:73384389 NA 0.37 5.78 0.3 1.74e-8 Intelligence (multi-trait analysis); CRC cis rs59043219 1 rs59043219 chr1:209970610 G/A cg22029157 chr1:209979665 IRF6 0.79 14.69 0.63 6.18e-38 Crohn's disease;Inflammatory bowel disease;Alzheimer's disease (APOE e4 interaction); CRC trans rs17685 0.753 rs6953665 chr7:75769049 C/T cg19862616 chr7:65841803 NCRNA00174 0.99 18.11 0.71 2.51e-51 Coffee consumption;Coffee consumption (cups per day); CRC cis rs875971 0.895 rs7782806 chr7:65657897 C/T cg18252515 chr7:66147081 NA 0.39 5.6 0.3 4.46e-8 Aortic root size; CRC trans rs617791 0.530 rs7934543 chr11:65752508 G/T cg17712092 chr4:129076599 LARP1B -0.47 -6.7 -0.35 9.13e-11 Breast cancer; CRC cis rs9814567 1.000 rs4334685 chr3:134304335 T/G cg06109529 chr3:134205091 CEP63;ANAPC13 -0.8 -11.7 -0.54 1.13e-26 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs10751667 0.666 rs6597957 chr11:982294 T/A ch.11.42038R chr11:967971 AP2A2 0.6 10.27 0.49 1.21e-21 Alzheimer's disease (late onset); CRC cis rs10504229 0.871 rs10504227 chr8:58162005 G/A cg05313129 chr8:58192883 C8orf71 -0.45 -7.05 -0.36 1.06e-11 Developmental language disorder (linguistic errors); CRC cis rs3617 0.572 rs2245538 chr3:52852060 T/C cg15147215 chr3:52552868 STAB1 -0.53 -9.27 -0.46 2.51e-18 Red blood cell count;Autism spectrum disorder or schizophrenia; CRC cis rs1707322 0.656 rs2991981 chr1:46057144 A/G cg06784218 chr1:46089804 CCDC17 -0.65 -11.93 -0.55 1.7e-27 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs7412746 0.658 rs11582281 chr1:150826831 T/C cg18016565 chr1:150552671 MCL1 0.45 6.16 0.32 2.07e-9 Melanoma; CRC cis rs79976124 0.797 rs77895756 chr6:66626782 C/T cg07460842 chr6:66804631 NA 0.76 9.45 0.46 6.58e-19 Type 2 diabetes; CRC cis rs2075371 0.933 rs1868785 chr7:133945855 G/C cg20476274 chr7:133979776 SLC35B4 0.74 12.81 0.58 9.33e-31 Mean platelet volume; CRC cis rs28829049 0.597 rs2066002 chr1:19504300 G/A cg13387374 chr1:19411106 UBR4 0.39 5.67 0.3 3.19e-8 QRS duration in Tripanosoma cruzi seropositivity; CRC cis rs1046896 1.000 rs1046875 chr17:80685426 A/G cg17346650 chr17:80929145 B3GNTL1 -0.36 -5.98 -0.31 5.84e-9 Glycated hemoglobin levels; CRC cis rs12950390 0.853 rs12451815 chr17:45855956 A/G cg24803719 chr17:45855879 NA -0.29 -6.31 -0.33 8.78e-10 IgG glycosylation; CRC cis rs9296092 0.538 rs35381461 chr6:33519751 T/C cg13560919 chr6:33536144 NA -0.44 -6.2 -0.32 1.71e-9 Age at smoking initiation in chronic obstructive pulmonary disease; CRC cis rs9914988 0.673 rs12325788 chr17:27080049 G/A cg16670446 chr17:27188758 MIR451;MIR144 0.6 10.58 0.5 1.07e-22 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs1867631 0.585 rs11208940 chr1:67127242 A/G cg02459107 chr1:67143332 SGIP1 -0.37 -6.54 -0.34 2.34e-10 Menopause (age at onset); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg03705947 chr1:68152081 GADD45A 0.48 6.96 0.36 1.84e-11 Response to antipsychotic treatment; CRC trans rs6545883 0.965 rs6734830 chr2:61731112 G/A cg11704114 chr12:21509398 SLCO1A2 -0.32 -6.03 -0.32 4.46e-9 Tuberculosis; CRC cis rs8105895 0.935 rs1560717 chr19:22292247 A/G cg02657401 chr19:22469223 NA -0.39 -5.82 -0.31 1.37e-8 Body mass index (change over time); CRC cis rs4975709 0.610 rs1531994 chr5:1859297 T/C cg11168104 chr5:1857477 NA -0.36 -6.15 -0.32 2.23e-9 Cardiovascular disease risk factors; CRC cis rs2841277 0.708 rs28600075 chr14:105408315 T/C cg14403583 chr14:105418241 AHNAK2 -0.33 -6.04 -0.32 4.21e-9 Rheumatoid arthritis; CRC cis rs1799949 1.000 rs12944458 chr17:41180772 C/T cg01879757 chr17:41196368 BRCA1 -0.41 -6.06 -0.32 3.7e-9 Menopause (age at onset); CRC trans rs2727020 0.729 rs1164666 chr11:49295867 C/T cg21153622 chr11:89784906 NA -0.44 -7.13 -0.37 6.61e-12 Coronary artery disease; CRC cis rs7215564 0.818 rs7214465 chr17:78566792 G/A cg09596252 chr17:78655493 RPTOR 0.67 6.21 0.32 1.58e-9 Myopia (pathological); CRC cis rs7640424 0.628 rs7628325 chr3:107816314 G/A cg09227934 chr3:107805635 CD47 -0.48 -6.06 -0.32 3.83e-9 Body mass index; CRC cis rs4665809 1.000 rs6546768 chr2:26328800 A/G cg27170947 chr2:26402098 FAM59B -0.45 -5.97 -0.31 6.09e-9 Gut microbiome composition (summer); CRC cis rs10504229 0.728 rs17804720 chr8:58154565 T/C cg05313129 chr8:58192883 C8orf71 -0.47 -6.18 -0.32 1.94e-9 Developmental language disorder (linguistic errors); CRC cis rs9911578 1.000 rs9892795 chr17:57023054 G/C cg12560992 chr17:57184187 TRIM37 0.93 17.28 0.69 4.48e-48 Intelligence (multi-trait analysis); CRC cis rs28386778 0.897 rs2665833 chr17:61906846 T/C cg07362569 chr17:61921086 SMARCD2 0.38 5.87 0.31 1.05e-8 Prudent dietary pattern; CRC cis rs2019137 0.936 rs2241978 chr2:113954006 A/G cg11763394 chr2:113992921 PAX8;LOC440839;LOC654433 -0.5 -7.2 -0.37 4.22e-12 Lymphocyte counts; CRC cis rs7429990 0.965 rs35199727 chr3:47946708 T/C cg11946769 chr3:48343235 NME6 0.49 6.19 0.32 1.8e-9 Educational attainment (years of education); CRC cis rs9534288 0.699 rs1409432 chr13:46668302 C/T cg15192986 chr13:46630673 CPB2 -0.65 -8.96 -0.44 2.38e-17 Blood protein levels; CRC trans rs1997103 0.863 rs2140916 chr7:55403154 A/C cg20935933 chr6:143382018 AIG1 0.52 6.72 0.35 7.8e-11 QRS interval (sulfonylurea treatment interaction); CRC cis rs3736485 0.816 rs882386 chr15:51882273 C/T cg08986416 chr15:51914746 DMXL2 -0.49 -6.8 -0.35 4.88e-11 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs9322193 0.926 rs9285525 chr6:150122389 C/G cg05861140 chr6:150128134 PCMT1 -0.43 -7.05 -0.36 1.03e-11 Lung cancer; CRC cis rs7613875 0.580 rs11709503 chr3:49991167 G/T cg05623727 chr3:50126028 RBM5 0.61 10.68 0.51 4.53e-23 Body mass index; CRC cis rs7811142 0.887 rs111972532 chr7:100069088 T/C cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.19 16.88 0.68 1.7e-46 Platelet count; CRC cis rs116095464 0.614 rs4371799 chr5:268192 C/A cg22496380 chr5:211416 CCDC127 -0.86 -10.22 -0.49 1.74e-21 Breast cancer; CRC cis rs651907 0.557 rs36002990 chr3:101437862 G/A cg12386194 chr3:101231763 SENP7 0.5 7.37 0.38 1.42e-12 Colorectal cancer; CRC cis rs1003719 0.788 rs2835574 chr21:38455324 C/A cg10648535 chr21:38446584 PIGP;TTC3 0.51 7.26 0.37 2.78e-12 Eye color traits; CRC cis rs6062302 0.522 rs6090476 chr20:62248001 G/A cg09650180 chr20:62225654 GMEB2 -0.51 -6.75 -0.35 6.74e-11 Glioblastoma; CRC cis rs2204008 0.837 rs11495548 chr12:38076756 C/T cg13010199 chr12:38710504 ALG10B 0.45 5.73 0.3 2.22e-8 Bladder cancer; CRC cis rs4074493 0.963 rs4074492 chr1:231172439 G/A cg22172038 chr1:231176991 FAM89A 0.34 5.89 0.31 9.48e-9 Carotid plaque burden (smoking interaction); CRC cis rs9291683 0.588 rs12506364 chr4:10023448 C/T cg11266682 chr4:10021025 SLC2A9 0.53 11.38 0.53 1.58e-25 Bone mineral density; CRC cis rs826838 1.000 rs826889 chr12:39101076 G/A cg26384229 chr12:38710491 ALG10B -0.62 -9.5 -0.46 4.4e-19 Heart rate; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg14925012 chr15:60771315 NARG2 0.46 6.19 0.32 1.74e-9 Anxiety disorder; CRC cis rs6594535 0.663 rs10062378 chr5:111040064 A/G cg06838283 chr5:111090142 C5orf13 0.41 5.65 0.3 3.43e-8 Chickenpox; CRC cis rs367943 1.000 rs348954 chr5:112821716 A/G cg12552261 chr5:112820674 MCC -0.49 -7.67 -0.39 1.9e-13 Type 2 diabetes; CRC cis rs172166 0.561 rs149976 chr6:27987776 C/T cg15786705 chr6:28176104 NA -0.47 -6.96 -0.36 1.88e-11 Cardiac Troponin-T levels; CRC cis rs2839186 0.770 rs2280956 chr21:47642323 C/G cg11766577 chr21:47581405 C21orf56 0.51 8.35 0.42 1.94e-15 Testicular germ cell tumor; CRC cis rs1728785 0.901 rs821169 chr16:68630184 C/T cg02972257 chr16:68554789 NA -0.55 -6.78 -0.35 5.45e-11 Ulcerative colitis; CRC cis rs9302635 0.550 rs35959677 chr16:72200801 G/T cg23815491 chr16:72088622 HP 0.58 7.21 0.37 3.95e-12 Blood protein levels; CRC cis rs1801251 0.893 rs11687128 chr2:233608901 T/C cg25237894 chr2:233734115 C2orf82 0.54 8.77 0.44 9.91e-17 Coronary artery disease; CRC cis rs6459804 1.000 rs58278053 chr7:157512934 A/T cg05585630 chr7:157510462 PTPRN2 -0.41 -6.38 -0.33 6.04e-10 Bipolar disorder and schizophrenia; CRC trans rs7618501 1.000 rs9872864 chr3:49792023 A/G cg21582582 chr3:182698605 DCUN1D1 -0.56 -8.08 -0.41 1.22e-14 Intelligence (multi-trait analysis); CRC cis rs11252926 0.563 rs58840923 chr10:578484 T/TGA cg09445902 chr10:555545 DIP2C 0.82 6.5 0.34 2.91e-10 Psychosis in Alzheimer's disease; CRC cis rs17826219 0.636 rs7221463 chr17:29080551 A/C cg01831904 chr17:28903510 LRRC37B2 -0.63 -6.49 -0.34 3.16e-10 Body mass index; CRC cis rs7618915 0.547 rs6976 chr3:52728804 C/T cg11645453 chr3:52864694 ITIH4 0.37 6.39 0.33 5.65e-10 Bipolar disorder; CRC cis rs9399137 0.507 rs6940878 chr6:135366309 G/A cg22676075 chr6:135203613 NA 0.59 8.82 0.44 6.74e-17 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; CRC cis rs801193 1.000 rs3800812 chr7:66223461 T/C cg18876405 chr7:65276391 NA 0.6 10.69 0.51 4.26e-23 Aortic root size; CRC cis rs11711311 0.955 rs9881563 chr3:113414031 C/T cg15478005 chr3:113465772 ATP6V1A;NAA50 -0.47 -6.73 -0.35 7.39e-11 IgG glycosylation; CRC cis rs9814567 1.000 rs6787371 chr3:134254991 A/G cg06109529 chr3:134205091 CEP63;ANAPC13 -0.8 -12.05 -0.55 5.8e-28 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs62064224 0.714 rs4794915 chr17:30634363 A/G cg25809561 chr17:30822961 MYO1D -0.52 -9.35 -0.46 1.39e-18 Schizophrenia; CRC cis rs77633900 0.772 rs16968196 chr15:76682238 C/T cg21673338 chr15:77095150 SCAPER -0.67 -5.62 -0.3 4.15e-8 Non-glioblastoma glioma;Glioma; CRC cis rs7786808 0.579 rs4045391 chr7:158181826 T/C cg09998033 chr7:158218633 PTPRN2 -0.54 -7.25 -0.37 3e-12 Obesity-related traits; CRC cis rs708547 0.874 rs1614251 chr4:57891386 C/T cg25525207 chr4:57843836 C4orf14;POLR2B -0.48 -5.92 -0.31 8.21e-9 Response to bleomycin (chromatid breaks); CRC cis rs425277 0.583 rs4648807 chr1:2040898 A/G cg12639453 chr1:2035780 PRKCZ -0.38 -7.39 -0.38 1.21e-12 Height; CRC cis rs372883 0.506 rs2832300 chr21:30749315 A/G cg08807101 chr21:30365312 RNF160 0.48 7.2 0.37 4.15e-12 Pancreatic cancer; CRC cis rs60871478 0.898 rs4720929 chr7:808009 T/C cg04727924 chr7:799746 HEATR2 -0.45 -6.79 -0.35 5.27e-11 Cerebrospinal P-tau181p levels; CRC cis rs7552404 0.690 rs7549863 chr1:76327923 T/C cg10523679 chr1:76189770 ACADM -0.65 -8.5 -0.42 6.68e-16 Blood metabolite levels;Acylcarnitine levels; CRC cis rs8105895 0.935 rs7259971 chr19:22237319 C/G cg02657401 chr19:22469223 NA -0.34 -5.65 -0.3 3.56e-8 Body mass index (change over time); CRC trans rs453301 0.571 rs330048 chr8:9087278 A/C cg08975724 chr8:8085496 FLJ10661 -0.43 -6.64 -0.34 1.3100000000000001e-10 Joint mobility (Beighton score); CRC cis rs11190604 1.000 rs35106985 chr10:102307542 T/C cg07080220 chr10:102295463 HIF1AN 0.47 5.66 0.3 3.31e-8 Palmitoleic acid (16:1n-7) levels; CRC cis rs9648716 1.000 rs6950946 chr7:140572545 T/C cg10747023 chr7:140774559 NA 0.45 5.82 0.31 1.36e-8 Type 2 diabetes; CRC cis rs2982552 0.901 rs2982561 chr6:152052652 C/T cg22157087 chr6:152012887 ESR1 0.41 6.31 0.33 9e-10 Bone properties (heel); CRC cis rs11098499 0.754 rs1849457 chr4:120254355 A/G cg09307838 chr4:120376055 NA 0.6 9.08 0.45 1.05e-17 Corneal astigmatism; CRC cis rs12220238 1.000 rs11000931 chr10:75984800 A/C cg19889307 chr10:75911429 ADK;AP3M1 -0.53 -5.63 -0.3 3.88e-8 Soluble interleukin-2 receptor subunit alpha; CRC trans rs7937682 0.889 rs1789355 chr11:111499718 T/C cg18187862 chr3:45730750 SACM1L 0.47 6.77 0.35 6.1e-11 Primary sclerosing cholangitis; CRC cis rs72781680 1.000 rs75046532 chr2:24167267 A/G cg08917208 chr2:24149416 ATAD2B 0.91 9.24 0.45 3.06e-18 Lymphocyte counts; CRC cis rs7312933 0.618 rs7954523 chr12:42681508 A/G cg19980929 chr12:42632907 YAF2 0.45 6.76 0.35 6.2e-11 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CRC cis rs1552244 0.882 rs6443279 chr3:10053599 C/A cg08888203 chr3:10149979 C3orf24 0.65 8.61 0.43 3.07e-16 Alzheimer's disease; CRC cis rs2243480 1.000 rs4718334 chr7:65789454 G/A cg18252515 chr7:66147081 NA 1.25 14.62 0.63 1.19e-37 Diabetic kidney disease; CRC cis rs4478858 0.735 rs11583123 chr1:31751772 T/C cg00250761 chr1:31883323 NA -0.44 -8.59 -0.43 3.52e-16 Alcohol dependence; CRC cis rs894734 0.567 rs7138907 chr12:54324576 C/T cg17410650 chr12:54324560 NA -0.43 -8.18 -0.41 6.25e-15 Adverse response to chemotherapy (neutropenia/leucopenia) (all antimetabolite drugs); CRC cis rs6088580 0.634 rs6087579 chr20:32985155 A/G cg08999081 chr20:33150536 PIGU -0.63 -11.85 -0.55 3.29e-27 Glomerular filtration rate (creatinine); CRC cis rs7246760 1.000 rs67844335 chr19:9898039 G/A cg16876255 chr19:9731953 ZNF561 0.69 5.69 0.3 2.79e-8 Pursuit maintenance gain; CRC cis rs2933343 0.951 rs789217 chr3:128593201 C/T cg11901034 chr3:128598214 ACAD9 -0.53 -6.38 -0.33 5.95e-10 IgG glycosylation; CRC cis rs11098699 0.821 rs4833890 chr4:124217864 G/C cg09941581 chr4:124220074 SPATA5 0.43 6.37 0.33 6.51e-10 Mosquito bite size; CRC cis rs734999 0.545 rs6666788 chr1:2567500 A/G cg18854424 chr1:2615690 NA -0.46 -8.96 -0.44 2.43e-17 Ulcerative colitis; CRC cis rs561341 0.941 rs7215147 chr17:30266711 G/A cg23018236 chr17:30244563 NA -0.47 -6.57 -0.34 1.92e-10 Hip circumference adjusted for BMI; CRC cis rs172166 0.637 rs1225597 chr6:28162087 C/T cg23161317 chr6:28129485 ZNF389 0.47 6.84 0.35 3.86e-11 Cardiac Troponin-T levels; CRC cis rs4862750 0.957 rs1030381 chr4:187903568 G/C cg27532560 chr4:187881888 NA -0.57 -10.23 -0.49 1.61e-21 Lobe attachment (rater-scored or self-reported); CRC cis rs10924970 0.687 rs12737933 chr1:235363908 C/T cg09010748 chr1:235293032 TOMM20 0.43 6.08 0.32 3.31e-9 Asthma; CRC cis rs2243480 1.000 rs316330 chr7:65605372 C/A cg18252515 chr7:66147081 NA -1.25 -14.78 -0.63 2.8e-38 Diabetic kidney disease; CRC cis rs4713118 0.629 rs149899 chr6:28019979 C/T cg25164649 chr6:28176230 NA 0.64 8.67 0.43 1.95e-16 Parkinson's disease; CRC trans rs7615952 0.512 rs34651730 chr3:125358640 T/C cg02007433 chr3:129722099 NA -0.61 -9.23 -0.45 3.33e-18 Blood pressure (smoking interaction); CRC cis rs11628318 0.570 rs4906231 chr14:103062227 T/C cg12046867 chr14:103022105 NA -0.77 -9.19 -0.45 4.41e-18 Platelet count; CRC cis rs10504229 0.683 rs2318147 chr8:58114931 C/T cg24829409 chr8:58192753 C8orf71 -0.62 -7.85 -0.4 6.06e-14 Developmental language disorder (linguistic errors); CRC cis rs6502050 0.835 rs7405738 chr17:80084227 A/G cg11859384 chr17:80120422 CCDC57 0.37 5.82 0.31 1.36e-8 Life satisfaction; CRC cis rs9467711 0.606 rs9379873 chr6:26402717 T/C cg16898833 chr6:26189333 HIST1H4D 0.92 7.53 0.38 4.85e-13 Autism spectrum disorder or schizophrenia; CRC cis rs62458065 0.640 rs28587905 chr7:32533054 C/T cg20159608 chr7:32802032 NA -0.59 -6.96 -0.36 1.87e-11 Metabolite levels (HVA/MHPG ratio); CRC cis rs2180341 0.521 rs12203812 chr6:127617816 A/T cg27446573 chr6:127587934 RNF146 0.45 6.31 0.33 8.85e-10 Breast cancer; CRC cis rs2576037 0.583 rs11660085 chr18:44529603 A/G cg19077165 chr18:44547161 KATNAL2 0.65 10.58 0.5 1.01e-22 Personality dimensions; CRC cis rs2032447 0.670 rs198834 chr6:26114372 G/A cg03517284 chr6:25882590 NA 0.44 6.07 0.32 3.45e-9 Intelligence (multi-trait analysis); CRC cis rs1552244 1.000 rs7652935 chr3:10151138 T/C cg16606324 chr3:10149918 C3orf24 0.73 9.63 0.47 1.7e-19 Alzheimer's disease; CRC cis rs9911578 1.000 rs9907499 chr17:56949044 A/G cg05425664 chr17:57184151 TRIM37 -0.49 -7.77 -0.39 9.89e-14 Intelligence (multi-trait analysis); CRC cis rs7899719 1.000 rs11001458 chr10:77431050 G/T cg24369728 chr10:77472158 NA 0.42 5.63 0.3 3.81e-8 Exploratory eye movement dysfunction in schizophrenia (total eye scanning length); CRC cis rs10140922 0.966 rs10083387 chr14:35823669 G/A cg07166546 chr14:35805898 NA -0.3 -5.97 -0.31 6.25e-9 Hip circumference adjusted for BMI; CRC cis rs7249698 1 rs7249698 chr19:17210615 G/A cg19418318 chr19:17219073 MYO9B 0.42 7.53 0.38 4.93e-13 Breast cancer; CRC trans rs2303319 0.504 rs62187658 chr2:162488095 A/C cg18122310 chr12:50236657 BCDIN3D -0.75 -6.09 -0.32 3.1e-9 Cognitive function; CRC cis rs57024841 0.500 rs6560652 chr9:139830940 C/T cg00693599 chr9:139836323 FBXW5 -0.37 -5.88 -0.31 1.01e-8 Beta-trace protein levels; CRC cis rs9359856 0.564 rs76069351 chr6:90425043 C/T cg13799429 chr6:90582589 CASP8AP2 -0.74 -7.44 -0.38 8.78e-13 Bipolar disorder; CRC cis rs1186222 0.967 rs1018945 chr7:75255748 C/G cg05145297 chr7:75264568 HIP1 0.52 9.1 0.45 9.05e-18 Basophil percentage of granulocytes;White blood cell count (basophil);Basophil percentage of white cells; CRC cis rs703842 0.585 rs10877022 chr12:58223937 A/G cg00677455 chr12:58241039 CTDSP2 0.84 12.69 0.57 2.67e-30 Multiple sclerosis; CRC cis rs4665809 1.000 rs6546727 chr2:26275282 C/T cg27170947 chr2:26402098 FAM59B -0.45 -5.94 -0.31 7.16e-9 Gut microbiome composition (summer); CRC cis rs941873 0.772 rs7920127 chr10:81122914 T/C cg09469691 chr10:81107165 PPIF 0.53 8.27 0.41 3.38e-15 Height; CRC cis rs2011503 0.941 rs2010506 chr19:19387356 C/T cg11584989 chr19:19387371 SF4 0.59 6.67 0.34 1.12e-10 Bipolar disorder; CRC cis rs9308731 0.644 rs4627572 chr2:111873378 T/C cg04202892 chr2:111875749 ACOXL 0.43 6.96 0.36 1.8e-11 Chronic lymphocytic leukemia; CRC cis rs7552404 0.731 rs6699682 chr1:76340123 A/G cg03433033 chr1:76189801 ACADM -0.64 -8.07 -0.41 1.29e-14 Blood metabolite levels;Acylcarnitine levels; CRC cis rs35146811 0.844 rs59261051 chr7:99650429 C/T cg13334819 chr7:99746414 C7orf59 -0.53 -6.81 -0.35 4.59e-11 Coronary artery disease; CRC cis rs2559856 1.000 rs2559860 chr12:102087636 C/T cg12924262 chr12:102091054 CHPT1 0.55 8.28 0.42 3.12e-15 Blood protein levels; CRC cis rs7772486 0.846 rs6908063 chr6:146403618 T/C cg23711669 chr6:146136114 FBXO30 0.62 10.7 0.51 3.84e-23 Lobe attachment (rater-scored or self-reported); CRC cis rs367943 1.000 rs367943 chr5:112809728 C/T cg12552261 chr5:112820674 MCC 0.5 7.33 0.37 1.78e-12 Type 2 diabetes; CRC cis rs62408225 0.894 rs17585295 chr6:90944831 C/T cg06866423 chr6:90926672 BACH2 0.45 7.32 0.37 1.88e-12 Eosinophil counts;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC cis rs12760731 0.565 rs34676994 chr1:178054513 A/T cg00404053 chr1:178313656 RASAL2 1.09 10.85 0.51 1.24e-23 Obesity-related traits; CRC cis rs1957429 0.614 rs7144637 chr14:65349709 A/G cg23373153 chr14:65346875 NA -0.65 -5.89 -0.31 9.49e-9 Pediatric areal bone mineral density (radius); CRC cis rs9916302 0.808 rs12948906 chr17:37644854 C/T cg07936489 chr17:37558343 FBXL20 -0.79 -11.82 -0.55 4.03e-27 Glomerular filtration rate (creatinine); CRC cis rs1790761 0.967 rs1638588 chr11:67199706 C/A cg17375396 chr11:67202808 RPS6KB2 0.33 5.65 0.3 3.48e-8 Mean corpuscular volume; CRC cis rs826838 1.000 rs826888 chr12:39104719 C/G cg13010199 chr12:38710504 ALG10B -0.4 -5.9 -0.31 8.82e-9 Heart rate; CRC cis rs877282 0.842 rs35872126 chr10:764545 G/A cg06581033 chr10:766294 NA -0.53 -5.88 -0.31 1.01e-8 Uric acid levels; CRC cis rs11212617 0.967 rs228592 chr11:108123189 C/A cg14761454 chr11:108092087 ATM;NPAT 0.43 6.46 0.34 3.76e-10 Response to metformin in type 2 diabetes (glycemic); CRC cis rs8180040 0.739 rs12488225 chr3:47235107 G/A cg27129171 chr3:47204927 SETD2 0.76 13.05 0.58 1.23e-31 Colorectal cancer; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg19824362 chr12:95467522 NR2C1 0.41 6.13 0.32 2.51e-9 Intelligence (multi-trait analysis); CRC cis rs7618501 1.000 rs1491986 chr3:49739086 C/T cg24308560 chr3:49941425 MST1R 0.45 7.07 0.36 9.36e-12 Intelligence (multi-trait analysis); CRC trans rs7618501 0.602 rs2013208 chr3:50129399 C/T cg21665057 chr3:196295764 WDR53;FBXO45 -0.52 -8.06 -0.41 1.43e-14 Intelligence (multi-trait analysis); CRC cis rs6543140 0.964 rs2080288 chr2:103022166 G/A cg03938978 chr2:103052716 IL18RAP 0.45 7.04 0.36 1.14e-11 Blood protein levels; CRC cis rs2836974 0.739 rs12482181 chr21:40548852 A/G cg06238570 chr21:40685208 BRWD1 0.78 10.69 0.51 4.36e-23 Cognitive function; CRC trans rs2470578 0.716 rs2733514 chr3:17323931 A/G cg24296761 chr19:42408458 ARHGEF1 -0.27 -6.03 -0.32 4.49e-9 Schizophrenia; CRC cis rs1878931 0.624 rs37810 chr16:3451881 C/T cg02880119 chr16:3481970 NA 0.42 5.93 0.31 7.49e-9 Body mass index (adult); CRC cis rs6545883 0.929 rs778154 chr2:61646631 T/C cg15711740 chr2:61764176 XPO1 0.47 6.09 0.32 3.23e-9 Tuberculosis; CRC cis rs72945132 0.882 rs12289915 chr11:70131956 G/C cg00319359 chr11:70116639 PPFIA1 0.67 7.4 0.38 1.13e-12 Coronary artery disease; CRC cis rs8141529 0.748 rs715531 chr22:29282679 A/G cg02153584 chr22:29168773 CCDC117 0.47 6.89 0.36 2.86e-11 Lymphocyte counts; CRC cis rs6933660 0.646 rs3816778 chr6:151773353 G/C cg14416726 chr6:151773293 C6orf211;RMND1 -0.77 -12.76 -0.58 1.49e-30 Menarche (age at onset); CRC cis rs5753618 0.539 rs1034588 chr22:31616301 A/G cg22777020 chr22:31556080 RNF185 -0.5 -5.68 -0.3 2.99e-8 Colorectal cancer; CRC cis rs853679 0.546 rs175597 chr6:27810626 T/C cg26587870 chr6:27730563 NA -0.59 -5.91 -0.31 8.72e-9 Depression; CRC cis rs9929218 1.000 rs9928847 chr16:68797893 C/T cg02972257 chr16:68554789 NA 0.44 5.67 0.3 3.13e-8 Colorectal cancer; CRC cis rs6502050 0.835 rs7221544 chr17:80087337 C/T cg25804541 chr17:80189381 SLC16A3 0.32 6.12 0.32 2.72e-9 Life satisfaction; CRC cis rs7223966 1.000 rs8067431 chr17:61817048 T/C cg23090583 chr17:61904693 PSMC5;FTSJ3 0.53 6.37 0.33 6.55e-10 Hip circumference adjusted for BMI;Body mass index; CRC cis rs9322193 0.923 rs9688861 chr6:149959060 G/T cg00933542 chr6:150070202 PCMT1 0.29 6.05 0.32 3.94e-9 Lung cancer; CRC cis rs4588572 0.643 rs1019739 chr5:77770241 G/C cg11547950 chr5:77652471 NA -0.53 -7.27 -0.37 2.66e-12 Triglycerides; CRC cis rs898097 0.578 rs2380173 chr17:80909157 G/T cg15369054 chr17:80825471 TBCD 0.34 5.63 0.3 3.8e-8 Breast cancer; CRC cis rs10504229 0.683 rs11781690 chr8:58132931 C/G cg05313129 chr8:58192883 C8orf71 -0.43 -6.11 -0.32 2.74e-9 Developmental language disorder (linguistic errors); CRC cis rs9467711 0.606 rs9379857 chr6:26367654 G/C cg16898833 chr6:26189333 HIST1H4D 0.76 6.58 0.34 1.88e-10 Autism spectrum disorder or schizophrenia; CRC cis rs7618501 0.521 rs55692411 chr3:49911155 G/A cg05623727 chr3:50126028 RBM5 0.58 9.82 0.48 4.07e-20 Intelligence (multi-trait analysis); CRC cis rs6502050 0.835 rs4789732 chr17:80131382 A/G cg09264619 chr17:80180166 NA -0.34 -5.76 -0.3 1.93e-8 Life satisfaction; CRC cis rs754466 0.510 rs55893027 chr10:79588209 C/T cg26805224 chr10:79626177 DLG5 -0.43 -6.41 -0.33 5.12e-10 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs7542091 0.813 rs2049999 chr1:210031331 A/G cg21951975 chr1:209979733 IRF6 0.35 5.94 0.31 7.11e-9 Monobrow; CRC cis rs60871478 0.588 rs6952577 chr7:872100 C/T cg05535760 chr7:792225 HEATR2 0.85 9.76 0.47 6.29e-20 Cerebrospinal P-tau181p levels; CRC cis rs2075671 0.903 rs4727459 chr7:100276821 T/C cg00334542 chr7:100209784 MOSPD3 -0.52 -6.63 -0.34 1.38e-10 Other erythrocyte phenotypes; CRC cis rs9660180 1.000 rs9660180 chr1:1723031 G/A cg23982607 chr1:1823379 GNB1 -0.88 -16.18 -0.67 9.76e-44 Body mass index; CRC cis rs853679 0.713 rs200991 chr6:27815494 A/C cg06470822 chr6:28175283 NA -0.66 -7.29 -0.37 2.33e-12 Depression; CRC trans rs7937682 1.000 rs10789843 chr11:111576158 C/T cg18187862 chr3:45730750 SACM1L -0.53 -7.42 -0.38 9.77e-13 Primary sclerosing cholangitis; CRC cis rs995000 0.931 rs1748200 chr1:63046039 T/C cg19896129 chr1:63156450 NA -0.43 -6.71 -0.35 8.47e-11 Triglyceride levels; CRC cis rs11992186 0.505 rs7845203 chr8:8145440 A/G cg06636001 chr8:8085503 FLJ10661 0.57 8.87 0.44 4.87e-17 Neuroticism; CRC cis rs798554 0.724 rs798498 chr7:2795882 T/G cg17321639 chr7:2759063 NA -0.44 -6.13 -0.32 2.56e-9 Height; CRC cis rs868943 0.743 rs10457303 chr6:116413841 C/T cg05304507 chr6:116381966 FRK 0.28 6.3 0.33 9.64e-10 Total cholesterol levels; CRC cis rs898097 0.625 rs2125479 chr17:80890262 A/G cg19046167 chr17:80928561 B3GNTL1 -0.41 -6.49 -0.34 3.1e-10 Breast cancer; CRC cis rs2677744 0.626 rs3743452 chr15:91497515 C/T cg23684204 chr15:91497937 RCCD1 -0.47 -7.37 -0.38 1.41e-12 Attention deficit hyperactivity disorder; CRC cis rs1799949 1.000 rs8074136 chr17:41342313 A/C cg23758822 chr17:41437982 NA 0.79 13.44 0.6 3.95e-33 Menopause (age at onset); CRC trans rs6472235 0.837 rs12114319 chr8:66930916 C/G cg07884673 chr3:53033167 SFMBT1 -0.45 -6.03 -0.32 4.47e-9 Myopia (pathological);Plateletcrit; CRC cis rs35306767 0.761 rs12359796 chr10:1021479 G/C cg20503657 chr10:835505 NA 0.94 10.71 0.51 3.53e-23 Eosinophil percentage of granulocytes; CRC cis rs10504229 0.728 rs55812114 chr8:58157453 C/T cg02725872 chr8:58115012 NA -0.59 -9.18 -0.45 4.97e-18 Developmental language disorder (linguistic errors); CRC cis rs6951245 1.000 rs74652290 chr7:1090109 G/A cg20603222 chr7:1096387 C7orf50;GPR146 -0.67 -8.02 -0.4 1.87e-14 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs11608355 0.515 rs61941591 chr12:109919965 A/C cg05360138 chr12:110035743 NA 0.78 8.76 0.43 1.07e-16 Neuroticism; CRC trans rs561341 1.000 rs564714 chr17:30318404 C/T cg27661571 chr11:113659931 NA -0.96 -11.16 -0.52 1e-24 Hip circumference adjusted for BMI; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg15876000 chr3:49067026 IMPDH2 0.45 6.27 0.33 1.15e-9 Response to antipsychotic treatment; CRC cis rs7618501 0.633 rs6771546 chr3:49968572 T/C cg24110177 chr3:50126178 RBM5 -0.49 -7.59 -0.39 3.29e-13 Intelligence (multi-trait analysis); CRC cis rs10256972 0.786 rs3735686 chr7:1062527 G/A cg07308232 chr7:1071921 C7orf50 -0.44 -6.06 -0.32 3.74e-9 Longevity;Endometriosis; CRC cis rs11098499 0.691 rs28396837 chr4:120271541 G/A cg24375607 chr4:120327624 NA 0.45 7.28 0.37 2.53e-12 Corneal astigmatism; CRC cis rs4969178 0.600 rs4969184 chr17:76393413 G/A cg05887092 chr17:76393375 PGS1 0.65 13.2 0.59 3.14e-32 HDL cholesterol levels; CRC cis rs870825 0.655 rs1527870 chr4:185616631 T/C cg04058563 chr4:185651563 MLF1IP 0.72 9.2 0.45 4.12e-18 Blood protein levels; CRC cis rs2456568 0.802 rs1108910 chr11:93629677 C/T cg26875233 chr11:93583750 C11orf90 0.34 6.67 0.34 1.11e-10 Response to serotonin reuptake inhibitors in major depressive disorder; CRC cis rs9682041 0.696 rs35177863 chr3:170090006 A/G cg11886554 chr3:170076028 SKIL 0.69 8.18 0.41 6.39e-15 Glomerular filtration rate in non diabetics (creatinine);Glomerular filtration rate (creatinine); CRC cis rs875971 0.964 rs778723 chr7:65829497 T/C cg11764359 chr7:65958608 NA 0.61 9.95 0.48 1.41e-20 Aortic root size; CRC cis rs7772486 0.654 rs6906402 chr6:146089307 C/G cg23711669 chr6:146136114 FBXO30 -0.78 -13.21 -0.59 3e-32 Lobe attachment (rater-scored or self-reported); CRC cis rs416603 0.967 rs11640138 chr16:11362729 A/G cg00044050 chr16:11439710 C16orf75 0.55 8.02 0.4 1.81e-14 Type 1 diabetes; CRC cis rs79387448 0.745 rs17027496 chr2:103178223 T/A cg00507830 chr2:103233733 NA 0.57 6.25 0.33 1.31e-9 Gut microbiota (bacterial taxa); CRC cis rs3862030 0.668 rs12781718 chr10:104227433 G/A cg11453585 chr10:104263688 ACTR1A;SUFU -0.77 -13.41 -0.59 5.15e-33 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for body mass index; CRC cis rs7927771 0.839 rs7124681 chr11:47529947 C/A cg05585544 chr11:47624801 NA -0.46 -8.25 -0.41 3.79e-15 Subjective well-being; CRC cis rs9611565 0.659 rs12484694 chr22:41919330 A/G cg17554472 chr22:41940697 POLR3H -0.54 -5.74 -0.3 2.21e-8 Vitiligo; CRC cis rs2760061 0.598 rs658238 chr1:228121291 A/G cg18477163 chr1:228402036 OBSCN -0.34 -5.69 -0.3 2.87e-8 Diastolic blood pressure; CRC cis rs1799949 0.965 rs34616041 chr17:41188786 G/A cg25072359 chr17:41440525 NA 0.45 6.55 0.34 2.16e-10 Menopause (age at onset); CRC cis rs7772486 0.790 rs9386141 chr6:146268623 T/A cg23711669 chr6:146136114 FBXO30 -0.65 -11.14 -0.52 1.1e-24 Lobe attachment (rater-scored or self-reported); CRC trans rs7395662 0.658 rs2865610 chr11:48772617 T/C cg21153622 chr11:89784906 NA -0.48 -7.68 -0.39 1.83e-13 HDL cholesterol; CRC cis rs9322193 0.962 rs3805753 chr6:150116798 C/T cg05861140 chr6:150128134 PCMT1 -0.43 -7.05 -0.36 1.03e-11 Lung cancer; CRC cis rs826838 0.586 rs10785554 chr12:38628749 T/A cg26384229 chr12:38710491 ALG10B 0.43 6.19 0.32 1.83e-9 Heart rate; CRC cis rs6748734 0.625 rs4563218 chr2:241820035 G/A cg16358738 chr2:241808595 AGXT -0.41 -7.26 -0.37 2.8e-12 Urinary metabolites; CRC cis rs3767633 0.925 rs10753666 chr1:161861147 C/G cg09175582 chr1:161736000 ATF6 0.7 6.29 0.33 1.03e-9 IgG glycosylation; CRC trans rs7618501 1.000 rs3749241 chr3:49744392 A/G cg21665057 chr3:196295764 WDR53;FBXO45 -0.85 -15.78 -0.66 3.69e-42 Intelligence (multi-trait analysis); CRC trans rs7011507 0.945 rs13282865 chr8:49206289 T/G cg04544946 chr8:978226 NA 0.46 6.09 0.32 3.1e-9 Inflammatory bowel disease;Ulcerative colitis; CRC cis rs7086803 1.000 rs7090269 chr10:114504533 A/G cg03281572 chr10:114502318 VTI1A -0.72 -6.04 -0.32 4.09e-9 Lung cancer; CRC cis rs916888 0.610 rs199453 chr17:44800946 C/T cg01570182 chr17:44337453 NA 0.72 9.1 0.45 8.71e-18 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs7772486 0.875 rs9373483 chr6:146364194 A/G cg23711669 chr6:146136114 FBXO30 0.68 11.85 0.55 3.22e-27 Lobe attachment (rater-scored or self-reported); CRC cis rs6963495 0.818 rs55922564 chr7:105155890 G/A cg13798780 chr7:105162888 PUS7 0.68 8.08 0.41 1.27e-14 Bipolar disorder (body mass index interaction); CRC cis rs7172677 0.501 rs8041446 chr15:75394517 C/T cg14664628 chr15:75095509 CSK 0.44 6.13 0.32 2.5e-9 Systemic lupus erythematosus and Systemic sclerosis; CRC cis rs2153535 0.580 rs2184586 chr6:8474182 A/G cg21535247 chr6:8435926 SLC35B3 0.5 7.53 0.38 4.89e-13 Motion sickness; CRC cis rs7020830 0.931 rs13295115 chr9:37157964 T/G cg14294708 chr9:37120828 ZCCHC7 1.18 24.24 0.8 3.36e-75 Schizophrenia; CRC trans rs7615952 0.512 rs4679430 chr3:125357893 T/C cg02007433 chr3:129722099 NA -0.61 -9.23 -0.45 3.33e-18 Blood pressure (smoking interaction); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg05481085 chr12:109549869 NA 0.43 6.56 0.34 2.06e-10 Intelligence (multi-trait analysis); CRC cis rs11628318 0.614 rs7155804 chr14:103114945 A/G cg23071808 chr14:103021642 NA 0.63 6.95 0.36 1.97e-11 Platelet count; CRC cis rs9443645 0.901 rs1572585 chr6:79690576 C/T cg09184832 chr6:79620586 NA -0.52 -9.45 -0.46 6.65e-19 Intelligence (multi-trait analysis); CRC cis rs2396545 0.634 rs35788385 chr11:570094 G/A cg09218773 chr11:619014 MUPCDH -0.42 -5.87 -0.31 1.05e-8 Systemic lupus erythematosus and Systemic sclerosis; CRC trans rs7615952 0.512 rs11921452 chr3:125359750 A/G cg00769240 chr8:12517080 NA -0.74 -10.23 -0.49 1.64e-21 Blood pressure (smoking interaction); CRC cis rs965469 0.545 rs6051846 chr20:3403824 A/G cg25506879 chr20:3388711 C20orf194 0.38 6.5 0.34 3.04e-10 IFN-related cytopenia; CRC cis rs947211 0.750 rs5014255 chr1:205753870 C/A cg26354017 chr1:205819088 PM20D1 0.41 5.72 0.3 2.37e-8 Parkinson's disease; CRC cis rs853679 0.517 rs3173443 chr6:28137027 T/G cg15845792 chr6:28175446 NA 1.04 13.89 0.61 7.67e-35 Depression; CRC cis rs6570726 1.000 rs441477 chr6:145848243 C/T cg13319975 chr6:146136371 FBXO30 -0.37 -5.66 -0.3 3.29e-8 Lobe attachment (rater-scored or self-reported); CRC trans rs12517041 1.000 rs7720974 chr5:23300191 T/C ch.8.1293020R chr8:59333349 UBXN2B -0.56 -6.2 -0.32 1.74e-9 Calcium levels; CRC trans rs11098499 0.908 rs11098527 chr4:120399906 A/G cg25214090 chr10:38739885 LOC399744 0.65 10.35 0.5 6.49e-22 Corneal astigmatism; CRC cis rs7618915 0.547 rs3755806 chr3:52643685 C/T cg18099408 chr3:52552593 STAB1 0.46 7.67 0.39 2.01e-13 Bipolar disorder; CRC cis rs1862618 0.671 rs2591970 chr5:56232595 T/C cg20203395 chr5:56204925 C5orf35 0.58 7.88 0.4 4.87e-14 Initial pursuit acceleration; CRC cis rs727505 1.000 rs59294613 chr7:124554267 C/A cg23710748 chr7:124431027 NA -0.68 -12.21 -0.56 1.59e-28 Lewy body disease; CRC cis rs763121 0.853 rs2413545 chr22:39092524 C/T cg06544989 chr22:39130855 UNC84B 0.45 6.52 0.34 2.64e-10 Menopause (age at onset); CRC cis rs9435341 0.965 rs1335053 chr1:107622823 C/T cg11070056 chr1:107600091 PRMT6 -0.39 -5.62 -0.3 4.03e-8 Facial morphology (factor 21, depth of nasal alae); CRC cis rs11098499 0.691 rs17009144 chr4:120270795 C/T cg24375607 chr4:120327624 NA -0.44 -7.06 -0.36 9.73e-12 Corneal astigmatism; CRC cis rs1403694 0.695 rs13095338 chr3:186435583 T/C cg04611788 chr3:186434169 KNG1 -0.61 -9.1 -0.45 8.64e-18 Blood protein levels; CRC cis rs910187 0.678 rs6124967 chr20:45813624 T/C cg27589058 chr20:45804311 EYA2 -0.38 -7.3 -0.37 2.12e-12 Migraine; CRC cis rs1223397 0.651 rs3001966 chr6:13312684 C/T cg20827128 chr6:13274284 PHACTR1 0.38 5.81 0.3 1.5e-8 Blood pressure; CRC cis rs10504229 1.000 rs117231141 chr8:58185465 A/G cg02725872 chr8:58115012 NA -0.38 -6.43 -0.33 4.44e-10 Developmental language disorder (linguistic errors); CRC cis rs2717559 0.522 rs10956987 chr8:143886613 T/C cg22687807 chr8:143858763 LYNX1 -0.75 -13.97 -0.61 3.8e-35 Urinary tract infection frequency; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg05565475 chr9:136223383 SURF2;SURF1 0.43 5.98 0.31 5.81e-9 Anxiety disorder; CRC trans rs3942852 0.568 rs4412719 chr11:48101660 T/A cg03929089 chr4:120376271 NA -0.59 -8.18 -0.41 6.07e-15 Acute lymphoblastic leukemia (childhood); CRC cis rs2481665 0.772 rs6668600 chr1:62536683 C/G cg18591186 chr1:62594603 INADL 0.53 7.3 0.37 2.25e-12 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs12142240 0.698 rs6696777 chr1:46810970 A/G cg14993813 chr1:46806288 NSUN4 -0.49 -6.26 -0.33 1.2e-9 Menopause (age at onset); CRC cis rs10504229 1.000 rs57186557 chr8:58177277 A/G cg02725872 chr8:58115012 NA -0.38 -6.43 -0.33 4.44e-10 Developmental language disorder (linguistic errors); CRC cis rs7666738 0.830 rs10856936 chr4:99011319 T/C cg05340658 chr4:99064831 C4orf37 0.59 9.04 0.45 1.36e-17 Colonoscopy-negative controls vs population controls; CRC cis rs853679 0.527 rs853683 chr6:28295039 A/G cg06470822 chr6:28175283 NA 0.48 6.58 0.34 1.84e-10 Depression; CRC cis rs7584330 0.666 rs1574530 chr2:238395708 A/T cg16989719 chr2:238392110 NA -0.43 -6.38 -0.33 6.02e-10 Prostate cancer; CRC trans rs2727020 0.587 rs1164658 chr11:49298551 C/A cg11707556 chr5:10655725 ANKRD33B 0.34 6.28 0.33 1.08e-9 Coronary artery disease; CRC cis rs7258465 1.000 rs7252707 chr19:18612257 G/A cg10790698 chr19:18539756 SSBP4 -0.41 -7.76 -0.39 1.06e-13 Breast cancer; CRC cis rs2735413 0.813 rs11644471 chr16:78077237 A/T cg04733911 chr16:78082701 NA -0.45 -7.5 -0.38 6.09e-13 Systolic blood pressure (alcohol consumption interaction); CRC cis rs6502050 0.799 rs9911129 chr17:80087819 C/T cg19223190 chr17:80058835 NA 0.39 6.16 0.32 2.12e-9 Life satisfaction; CRC cis rs7772486 0.790 rs9497424 chr6:146225271 C/A cg13319975 chr6:146136371 FBXO30 0.39 5.85 0.31 1.18e-8 Lobe attachment (rater-scored or self-reported); CRC cis rs7072216 0.881 rs1079179 chr10:100149346 T/C cg26618903 chr10:100175079 PYROXD2 -0.37 -6.2 -0.32 1.72e-9 Metabolite levels; CRC cis rs2976388 0.647 rs2082801 chr8:143786461 A/G cg12516270 chr8:143859308 LYNX1 0.41 7.31 0.37 2.04e-12 Urinary tract infection frequency; CRC trans rs360798 0.512 rs2710637 chr2:63173450 G/A cg05376469 chr2:102649931 NA -0.4 -6.44 -0.33 4.22e-10 Coronary artery disease; CRC cis rs7618915 0.547 rs62253733 chr3:52653414 A/G cg11645453 chr3:52864694 ITIH4 0.36 6.39 0.33 5.61e-10 Bipolar disorder; CRC cis rs6502050 0.835 rs62078305 chr17:80085326 G/A cg09264619 chr17:80180166 NA 0.36 6.08 0.32 3.4e-9 Life satisfaction; CRC cis rs2404602 0.647 rs12904149 chr15:77043652 A/C cg23625390 chr15:77176239 SCAPER -0.84 -12.98 -0.58 2.2e-31 Blood metabolite levels; CRC cis rs10504229 0.775 rs10504228 chr8:58162053 T/G cg24829409 chr8:58192753 C8orf71 -0.6 -8.05 -0.41 1.53e-14 Developmental language disorder (linguistic errors); CRC cis rs1697139 0.583 rs11739587 chr5:66540481 A/C cg16691251 chr5:66510806 NA -0.42 -7.59 -0.39 3.3e-13 Breast cancer; CRC cis rs17826219 0.706 rs73271850 chr17:29142140 A/G cg13385521 chr17:29058706 SUZ12P 0.73 8.39 0.42 1.43e-15 Body mass index; CRC cis rs2816062 0.786 rs2745316 chr1:18896830 G/A cg18795169 chr1:18902165 NA -0.91 -18.84 -0.72 3.08e-54 Urate levels in lean individuals; CRC cis rs3849570 0.643 rs6548779 chr3:81968512 A/G cg07356753 chr3:81810745 GBE1 -0.46 -6.16 -0.32 2.16e-9 Waist circumference;Body mass index; CRC cis rs524281 0.773 rs2155031 chr11:66030927 C/T cg14036092 chr11:66035641 RAB1B -0.55 -6.04 -0.32 4.16e-9 Electroencephalogram traits; CRC cis rs9908102 0.740 rs2286336 chr17:12915941 C/T cg26162695 chr17:12921313 ELAC2 -0.44 -5.95 -0.31 7.04e-9 Schizophrenia; CRC cis rs897984 0.683 rs729482 chr16:31016970 T/C cg00531865 chr16:30841666 NA -0.43 -5.85 -0.31 1.16e-8 Dementia with Lewy bodies; CRC cis rs8141797 0.818 rs762271 chr22:24448082 T/C cg20894457 chr22:24584366 SUSD2 -0.65 -6.71 -0.35 8.4e-11 Amyotrophic lateral sclerosis;Coronary artery disease; CRC cis rs7772486 0.790 rs2256998 chr6:146207657 A/C cg23711669 chr6:146136114 FBXO30 0.71 12.52 0.57 1.15e-29 Lobe attachment (rater-scored or self-reported); CRC cis rs9309413 0.679 rs13393517 chr2:68556100 G/A cg21581504 chr2:68545960 CNRIP1 0.32 6.18 0.32 1.86e-9 Metabolite levels; CRC cis rs769267 1.000 rs8103197 chr19:19443466 C/T cg03709012 chr19:19516395 GATAD2A -0.67 -10.3 -0.49 9.29e-22 Tonsillectomy; CRC cis rs2032447 0.520 rs198818 chr6:26125711 A/C cg18357526 chr6:26021779 HIST1H4A -0.69 -10.24 -0.49 1.49e-21 Intelligence (multi-trait analysis); CRC cis rs56235845 0.694 rs6860069 chr5:176755841 C/T cg17509989 chr5:176798049 RGS14 0.63 10.46 0.5 2.78e-22 Hemoglobin concentration;Hematocrit; CRC cis rs9322193 0.886 rs9767555 chr6:149968158 T/C cg05861140 chr6:150128134 PCMT1 -0.38 -5.75 -0.3 2.03e-8 Lung cancer; CRC cis rs10504229 0.683 rs59528137 chr8:58138565 C/T cg20607798 chr8:58055168 NA 0.54 6.2 0.32 1.68e-9 Developmental language disorder (linguistic errors); CRC cis rs708547 0.874 rs1713978 chr4:57875879 G/A cg25525207 chr4:57843836 C4orf14;POLR2B -0.47 -5.82 -0.31 1.42e-8 Response to bleomycin (chromatid breaks); CRC cis rs10504229 0.595 rs77615399 chr8:58117394 C/G cg02290350 chr8:58132656 NA -0.58 -8.16 -0.41 7.29e-15 Developmental language disorder (linguistic errors); CRC cis rs3008870 1.000 rs3008894 chr1:67377739 A/G cg08660285 chr1:67390436 MIER1;WDR78 1.04 15.36 0.65 1.54e-40 Lymphocyte percentage of white cells; CRC cis rs11608355 0.545 rs11066782 chr12:109910552 C/T cg05360138 chr12:110035743 NA 0.78 8.75 0.43 1.15e-16 Neuroticism; CRC cis rs9462027 0.561 rs2814972 chr6:34566975 T/C cg07306190 chr6:34760872 UHRF1BP1 -0.34 -5.9 -0.31 9.03e-9 Systemic lupus erythematosus; CRC cis rs765787 0.530 rs11636367 chr15:45535862 A/G cg24006582 chr15:45444508 DUOX1 -0.57 -8.76 -0.43 1.08e-16 Uric acid levels; CRC cis rs968567 0.638 rs7943728 chr11:61547068 G/A cg23760165 chr11:61595485 FADS2 -0.47 -6.25 -0.33 1.25e-9 Blood metabolite levels;Rheumatoid arthritis;Vitiligo;Glycerophospholipid levels; CRC cis rs7772486 0.806 rs4243478 chr6:146284560 A/G cg23711669 chr6:146136114 FBXO30 -0.64 -10.63 -0.51 6.98e-23 Lobe attachment (rater-scored or self-reported); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg14997559 chr19:40950494 SERTAD3 0.43 6.27 0.33 1.11e-9 Intelligence (multi-trait analysis); CRC cis rs3733585 0.699 rs62294331 chr4:9959889 A/G cg00071950 chr4:10020882 SLC2A9 -0.54 -9.65 -0.47 1.42e-19 Cleft plate (environmental tobacco smoke interaction); CRC cis rs6951245 1.000 rs28528096 chr7:1070912 G/C cg26224354 chr7:1096374 C7orf50;GPR146 -0.88 -11.08 -0.52 1.89e-24 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs2179367 0.959 rs652807 chr6:149737495 A/G cg07828024 chr6:149772892 ZC3H12D 0.36 6.02 0.32 4.6e-9 Dupuytren's disease; CRC cis rs2462686 1.000 rs2462686 chr7:45982460 A/G cg15898840 chr7:45960834 IGFBP3 -0.38 -5.72 -0.3 2.34e-8 Major depressive disorder; CRC cis rs2179367 0.959 rs9322178 chr6:149693267 G/C cg11245181 chr6:149772854 ZC3H12D -0.42 -6.47 -0.34 3.48e-10 Dupuytren's disease; CRC cis rs9522267 0.535 rs7329118 chr13:112232693 C/T cg14352298 chr13:112236639 NA 0.3 6.71 0.35 8.5e-11 Hepatitis; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg03228222 chr19:18747721 KLHL26 0.38 6.07 0.32 3.59e-9 Liver disease severity in Alagille syndrome; CRC cis rs9300255 0.830 rs28413626 chr12:123861452 G/A cg00376283 chr12:123451042 ABCB9 -0.49 -6.36 -0.33 6.68e-10 Neutrophil percentage of white cells; CRC cis rs7726839 0.526 rs11960159 chr5:568685 C/T cg09021430 chr5:549028 NA -0.82 -10.78 -0.51 2.12e-23 Obesity-related traits; CRC cis rs11229555 0.645 rs12272911 chr11:58183839 G/C cg15696309 chr11:58395628 NA -0.81 -10.31 -0.49 8.83e-22 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; CRC cis rs11105298 0.891 rs10777184 chr12:89919568 C/T cg00757033 chr12:89920650 WDR51B 0.37 6.0 0.31 5.15e-9 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; CRC cis rs3771570 0.901 rs55764424 chr2:242407467 C/T cg21155796 chr2:242212141 HDLBP 0.59 6.65 0.34 1.24e-10 Prostate cancer; CRC cis rs1448094 0.809 rs11117103 chr12:86314431 C/T cg02569458 chr12:86230093 RASSF9 0.35 5.9 0.31 9.26e-9 Major depressive disorder; CRC cis rs172166 0.561 rs149976 chr6:27987776 C/T cg12273811 chr6:28175739 NA -0.44 -6.53 -0.34 2.46e-10 Cardiac Troponin-T levels; CRC cis rs67478160 0.595 rs12879501 chr14:104272634 G/T cg01849466 chr14:104193079 ZFYVE21 -0.46 -8.11 -0.41 1.01e-14 Schizophrenia; CRC cis rs1881797 0.527 rs78398999 chr1:247686970 G/A cg21399703 chr1:247681439 NA 0.49 5.7 0.3 2.61e-8 Acute lymphoblastic leukemia (childhood); CRC cis rs599083 0.530 rs2508834 chr11:68175354 C/T cg16797656 chr11:68205561 LRP5 -0.37 -6.09 -0.32 3.17e-9 Bone mineral density (spine); CRC cis rs2976388 0.566 rs2585141 chr8:143806343 G/A cg24046110 chr8:143859143 LYNX1 -0.46 -7.51 -0.38 5.72e-13 Urinary tract infection frequency; CRC cis rs447 1.000 rs6978184 chr7:83778360 C/T cg22846510 chr7:83753280 SEMA3A -0.56 -7.01 -0.36 1.34e-11 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs4423214 0.879 rs1792281 chr11:71135496 G/A cg05163923 chr11:71159392 DHCR7 -0.62 -7.55 -0.38 4.19e-13 Vitamin D levels; CRC cis rs3857067 1.000 rs6532463 chr4:95027048 G/T cg11021082 chr4:95130006 SMARCAD1 -0.41 -6.22 -0.32 1.55e-9 QT interval; CRC trans rs6601327 0.575 rs6994574 chr8:9578255 G/A cg06636001 chr8:8085503 FLJ10661 -0.51 -7.4 -0.38 1.15e-12 Multiple myeloma (hyperdiploidy); CRC cis rs919433 0.963 rs10166569 chr2:198183439 G/A cg03934865 chr2:198174659 NA -0.43 -6.81 -0.35 4.66e-11 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC cis rs4713118 0.516 rs7739216 chr6:28079946 G/T cg15845792 chr6:28175446 NA 1.0 13.06 0.58 1.11e-31 Parkinson's disease; CRC cis rs7618501 0.573 rs2624824 chr3:50088266 T/C cg24308560 chr3:49941425 MST1R 0.5 8.2 0.41 5.41e-15 Intelligence (multi-trait analysis); CRC cis rs801193 0.805 rs12532355 chr7:66070584 C/G cg18876405 chr7:65276391 NA -0.6 -10.65 -0.51 5.75e-23 Aortic root size; CRC cis rs7772486 0.686 rs7739735 chr6:146123536 G/A cg13319975 chr6:146136371 FBXO30 -0.42 -6.32 -0.33 8.58e-10 Lobe attachment (rater-scored or self-reported); CRC cis rs9322193 0.962 rs4869730 chr6:150129323 A/G cg05861140 chr6:150128134 PCMT1 -0.41 -6.55 -0.34 2.28e-10 Lung cancer; CRC cis rs2739330 0.828 rs5760108 chr22:24252668 G/T cg11060661 chr22:24314208 DDT;DDTL 0.49 8.4 0.42 1.31e-15 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs4363385 0.818 rs419721 chr1:153006902 C/T cg25856811 chr1:152973957 SPRR3 -0.25 -6.99 -0.36 1.51e-11 Inflammatory skin disease; CRC cis rs17253792 0.822 rs75995456 chr14:56073194 A/G cg24579896 chr14:56047964 C14orf33;KTN1 0.71 5.69 0.3 2.81e-8 Putamen volume; CRC cis rs7264396 0.563 rs2425088 chr20:34303902 C/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.48 -6.67 -0.35 1.06e-10 Total cholesterol levels; CRC cis rs9381040 0.610 rs2268191 chr6:41027653 G/C cg09580153 chr6:41068724 NFYA;LOC221442 -0.42 -6.15 -0.32 2.19e-9 Alzheimer's disease (late onset); CRC cis rs1552244 0.882 rs7636817 chr3:10014876 G/T cg10729496 chr3:10149963 C3orf24 0.48 6.22 0.32 1.54e-9 Alzheimer's disease; CRC cis rs9733 0.744 rs12568757 chr1:150729793 C/T cg18016565 chr1:150552671 MCL1 -0.39 -5.69 -0.3 2.75e-8 Tonsillectomy; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg17169982 chr17:80787973 TBCD;ZNF750 0.42 6.58 0.34 1.83e-10 Liver disease severity in Alagille syndrome; CRC cis rs6723226 1.000 rs6723226 chr2:32849207 C/T cg02381751 chr2:32503542 YIPF4 0.49 6.86 0.35 3.38e-11 Intelligence (multi-trait analysis); CRC cis rs10876993 0.855 rs1689585 chr12:58080140 A/G cg18357645 chr12:58087776 OS9 -0.61 -8.66 -0.43 2.22e-16 Celiac disease or Rheumatoid arthritis; CRC cis rs9583531 0.600 rs7330080 chr13:111367115 C/T cg24331049 chr13:111365604 ING1 0.53 7.32 0.37 1.9e-12 Coronary artery disease; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg11651961 chr2:54197711 PSME4 0.41 6.12 0.32 2.65e-9 Intelligence (multi-trait analysis); CRC cis rs6951245 0.882 rs10256720 chr7:1210825 C/G cg22907277 chr7:1156413 C7orf50 0.76 8.42 0.42 1.17e-15 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs1448094 0.817 rs7973694 chr12:86335589 A/G cg02569458 chr12:86230093 RASSF9 0.46 7.78 0.39 9.25e-14 Major depressive disorder; CRC cis rs11645898 0.872 rs72791121 chr16:72225294 C/T cg14768367 chr16:72042858 DHODH -0.59 -6.69 -0.35 9.7e-11 Blood protein levels; CRC trans rs875971 0.660 rs2191268 chr7:66110224 C/T cg19310740 chr8:103424477 UBR5 -0.41 -6.4 -0.33 5.31e-10 Aortic root size; CRC cis rs73200209 0.744 rs17498872 chr12:116669888 A/T cg01776926 chr12:116560359 MED13L -0.58 -6.5 -0.34 3.06e-10 Total body bone mineral density; CRC cis rs5769707 0.609 rs2007024 chr22:49988815 C/T cg20744362 chr22:50050164 C22orf34 0.31 5.74 0.3 2.12e-8 Monocyte count;Monocyte percentage of white cells; CRC trans rs561341 0.882 rs2521594 chr17:30302087 C/T cg20587970 chr11:113659929 NA -1.39 -19.56 -0.73 4.54e-57 Hip circumference adjusted for BMI; CRC cis rs1799949 1.000 rs2271574 chr17:41327648 T/C cg25072359 chr17:41440525 NA 0.46 6.91 0.36 2.52e-11 Menopause (age at onset); CRC trans rs11031096 0.666 rs1662173 chr11:4127649 C/G cg22978087 chr8:24814126 NEFL 0.32 5.98 0.31 5.73e-9 Mean corpuscular volume;Mean corpuscular hemoglobin; CRC cis rs9517320 0.534 rs4772090 chr13:99150674 T/C cg20487152 chr13:99095054 FARP1 -0.43 -6.3 -0.33 9.37e-10 Longevity; CRC cis rs883565 0.502 rs7427462 chr3:38963275 G/A cg01426195 chr3:39028469 NA 0.42 7.07 0.36 9.39e-12 Handedness; CRC cis rs7089973 0.872 rs34683721 chr10:116619849 G/A cg23260525 chr10:116636907 FAM160B1 0.31 6.75 0.35 6.66e-11 Bipolar disorder or attention deficit hyperactivity disorder; CRC cis rs2115630 1.000 rs2879828 chr15:85361977 G/T cg11189052 chr15:85197271 WDR73 -0.56 -9.17 -0.45 5.13e-18 P wave terminal force; CRC trans rs4650994 0.544 rs4075631 chr1:178506594 C/A cg05059571 chr16:84539110 KIAA1609 -0.6 -8.19 -0.41 5.95e-15 HDL cholesterol levels;HDL cholesterol; CRC cis rs7666738 0.800 rs13107586 chr4:99028788 G/C cg05340658 chr4:99064831 C4orf37 0.61 9.42 0.46 8.23e-19 Colonoscopy-negative controls vs population controls; CRC trans rs9329221 0.592 rs7832708 chr8:10190040 C/T cg16141378 chr3:129829833 LOC729375 -0.46 -6.94 -0.36 2.15e-11 Neuroticism; CRC trans rs7824557 0.583 rs2736306 chr8:11239762 A/T cg08975724 chr8:8085496 FLJ10661 0.42 6.08 0.32 3.25e-9 Retinal vascular caliber; CRC cis rs9517320 1.000 rs7994160 chr13:99132749 C/A cg20487152 chr13:99095054 FARP1 0.37 6.14 0.32 2.33e-9 Longevity; CRC cis rs62209 0.530 rs17444979 chr10:10994159 C/T cg26901096 chr10:10994189 LOC254312 0.43 5.89 0.31 9.79e-9 Alzheimer's disease (late onset); CRC trans rs10207628 1.000 rs1530047 chr2:127848936 A/C cg22628694 chr19:58663362 ZNF329 0.57 6.02 0.31 4.78e-9 Psychosis and Alzheimer's disease; CRC cis rs4523957 0.614 rs1563966 chr17:2095954 A/G cg16513277 chr17:2031491 SMG6 0.51 8.76 0.43 1.07e-16 Autism spectrum disorder or schizophrenia;Schizophrenia; CRC cis rs747650 0.504 rs10769225 chr11:46982481 G/A cg19486271 chr11:47235900 DDB2 -0.44 -5.84 -0.31 1.24e-8 Acne (severe); CRC trans rs11800820 0.595 rs35558093 chr1:246711077 A/G cg26885821 chr6:124125002 NKAIN2 0.37 6.04 0.32 4.26e-9 Obesity-related traits; CRC cis rs501120 1.000 rs503859 chr10:44753560 G/C cg09554077 chr10:44749378 NA 0.89 13.32 0.59 1.14e-32 Coronary artery disease;Coronary heart disease; CRC cis rs2721195 0.654 rs4610795 chr8:145881333 C/T cg10700019 chr8:145984882 NA 0.33 6.53 0.34 2.52e-10 Age at first birth; CRC cis rs9292777 0.901 rs6896969 chr5:40424426 A/C cg09067459 chr5:40385259 NA 0.53 9.25 0.45 3.02e-18 Crohn's disease;Multiple sclerosis; CRC cis rs7412746 0.634 rs12409208 chr1:150860055 A/G cg10589385 chr1:150898437 SETDB1 0.33 6.95 0.36 1.92e-11 Melanoma; CRC cis rs7647973 1.000 rs11710434 chr3:49346130 T/C cg07636037 chr3:49044803 WDR6 0.61 7.34 0.38 1.65e-12 Menarche (age at onset); CRC cis rs73001065 0.636 rs73002960 chr19:19582992 C/T cg03709012 chr19:19516395 GATAD2A 0.8 6.21 0.32 1.62e-9 LDL cholesterol; CRC cis rs7909074 0.865 rs10900123 chr10:45376574 C/T cg05187965 chr10:45406764 TMEM72 -0.36 -8.57 -0.43 4.21e-16 Mean corpuscular volume; CRC cis rs3617 0.573 rs62253582 chr3:52928333 G/A cg18099408 chr3:52552593 STAB1 0.36 6.14 0.32 2.43e-9 Red blood cell count;Autism spectrum disorder or schizophrenia; CRC cis rs4728302 0.869 rs10155909 chr7:133593036 A/G cg03336402 chr7:133662267 EXOC4 -0.45 -6.56 -0.34 2.04e-10 Intelligence;Intelligence (multi-trait analysis); CRC cis rs9399137 0.507 rs4896129 chr6:135349845 C/T cg24558204 chr6:135376177 HBS1L 0.63 9.58 0.47 2.4e-19 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; CRC cis rs3772130 0.923 rs3805127 chr3:121556751 G/A cg20356878 chr3:121714668 ILDR1 0.53 8.28 0.42 3.06e-15 Cognitive performance; CRC cis rs4665809 0.567 rs6711402 chr2:26430983 A/G cg27170947 chr2:26402098 FAM59B -0.68 -8.39 -0.42 1.41e-15 Gut microbiome composition (summer); CRC cis rs7208859 0.623 rs55811708 chr17:29104731 G/T cg13385521 chr17:29058706 SUZ12P 0.74 8.45 0.42 9.84e-16 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs981844 0.740 rs6841173 chr4:154682563 A/G cg10279832 chr4:154682576 RNF175 0.38 5.81 0.3 1.51e-8 Response to statins (LDL cholesterol change); CRC cis rs2882667 0.964 rs12719517 chr5:138305502 C/T cg09476006 chr5:138032270 NA 0.47 7.44 0.38 9.02e-13 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs9814567 0.964 rs6776203 chr3:134234345 C/T cg06541857 chr3:134203789 ANAPC13;CEP63 -0.4 -6.05 -0.32 4.03e-9 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs7208859 0.725 rs9891656 chr17:29243355 A/T cg13385521 chr17:29058706 SUZ12P 0.52 6.99 0.36 1.5e-11 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs2535633 0.631 rs2245424 chr3:53003021 G/C cg11645453 chr3:52864694 ITIH4 -0.44 -8.6 -0.43 3.19e-16 Body mass index; CRC cis rs1862618 0.756 rs13356762 chr5:56110992 G/T cg20203395 chr5:56204925 C5orf35 -0.7 -8.28 -0.42 3.23e-15 Initial pursuit acceleration; CRC cis rs6558530 0.692 rs7818406 chr8:1701250 C/T cg19131313 chr8:1704013 NA -0.48 -5.74 -0.3 2.17e-8 Systolic blood pressure; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg07876271 chr5:5422799 KIAA0947 0.46 6.21 0.32 1.63e-9 Anxiety disorder; CRC cis rs12980942 0.872 rs2053086 chr19:41799475 C/T cg25627403 chr19:41769009 HNRNPUL1 -0.54 -6.12 -0.32 2.59e-9 Coronary artery disease; CRC cis rs294883 0.821 rs9365035 chr6:159703722 C/T cg14500486 chr6:159655392 FNDC1 -0.35 -5.73 -0.3 2.23e-8 Coronary artery disease; CRC cis rs933688 0.938 rs7705465 chr5:90680949 G/A cg26981201 chr5:90679533 LOC100129716;ARRDC3 1.02 15.59 0.65 1.97e-41 Smoking behavior; CRC cis rs6756513 0.501 rs7581977 chr2:70174054 C/T cg02498382 chr2:70120550 SNRNP27 0.49 8.14 0.41 8.52e-15 Breast cancer;Platelet count; CRC trans rs9545047 0.716 rs9530920 chr13:79997389 C/T cg07061582 chr15:90234082 PEX11A;WDR93 0.41 5.98 0.31 5.82e-9 Schizophrenia; CRC cis rs561341 0.941 rs8081016 chr17:30331751 A/G cg00745463 chr17:30367425 LRRC37B -0.88 -9.63 -0.47 1.7e-19 Hip circumference adjusted for BMI; CRC cis rs7208859 0.623 rs9890862 chr17:29125450 C/A cg13385521 chr17:29058706 SUZ12P 0.74 8.44 0.42 9.97e-16 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs13064411 0.696 rs7624994 chr3:113228009 T/C cg18753928 chr3:113234510 CCDC52 -0.7 -10.74 -0.51 2.89e-23 Response to simvastatin treatment (PCSK9 protein level change); CRC cis rs3126085 0.935 rs4845751 chr1:152208997 T/C cg09127314 chr1:152161683 NA 0.47 6.04 0.32 4.25e-9 Atopic dermatitis; CRC cis rs28386778 0.863 rs6504178 chr17:61812733 A/G cg06601766 chr17:61851465 DDX42;CCDC47 -0.44 -5.96 -0.31 6.39e-9 Prudent dietary pattern; CRC cis rs10504229 0.683 rs11786074 chr8:58133532 A/G cg02725872 chr8:58115012 NA -0.64 -11.55 -0.54 3.85e-26 Developmental language disorder (linguistic errors); CRC cis rs2816062 0.813 rs2816051 chr1:18895460 A/G cg18795169 chr1:18902165 NA -0.92 -19.57 -0.73 4.36e-57 Urate levels in lean individuals; CRC cis rs7726839 0.540 rs4957083 chr5:659343 T/C cg09021430 chr5:549028 NA -0.73 -8.23 -0.41 4.37e-15 Obesity-related traits; CRC cis rs2204008 0.683 rs11522927 chr12:38137537 C/T cg13010199 chr12:38710504 ALG10B 0.48 6.07 0.32 3.58e-9 Bladder cancer; CRC cis rs11650494 0.710 rs61427980 chr17:47473580 A/G cg08112188 chr17:47440006 ZNF652 0.69 6.28 0.33 1.05e-9 Prostate cancer; CRC cis rs6088580 0.634 rs6141465 chr20:32967314 T/C cg24642439 chr20:33292090 TP53INP2 -0.38 -6.44 -0.33 4.15e-10 Glomerular filtration rate (creatinine); CRC cis rs4713118 0.621 rs4713132 chr6:28034035 A/G cg21251018 chr6:28226885 NKAPL 0.47 6.38 0.33 6.15e-10 Parkinson's disease; CRC cis rs2976388 0.590 rs10087426 chr8:143814554 G/A cg24046110 chr8:143859143 LYNX1 -0.43 -6.99 -0.36 1.51e-11 Urinary tract infection frequency; CRC cis rs7591163 0.959 rs2396497 chr2:228724139 T/C cg20647610 chr2:228736258 WDR69 -0.47 -6.46 -0.34 3.72e-10 Blood pressure; CRC cis rs9487051 0.676 rs13210693 chr6:109598964 A/G cg01475377 chr6:109611718 NA 0.36 6.2 0.32 1.74e-9 Reticulocyte fraction of red cells; CRC cis rs6964587 0.967 rs28399886 chr7:91638451 A/G cg17063962 chr7:91808500 NA 0.8 14.24 0.62 3.57e-36 Breast cancer; CRC cis rs7552404 0.731 rs11161845 chr1:76367559 T/C cg10523679 chr1:76189770 ACADM 0.73 8.75 0.43 1.11e-16 Blood metabolite levels;Acylcarnitine levels; CRC cis rs1801251 1.000 rs2044449 chr2:233718808 G/A cg25237894 chr2:233734115 C2orf82 -0.54 -8.76 -0.43 1.04e-16 Coronary artery disease; CRC trans rs2303319 0.504 rs62189041 chr2:162599506 T/C cg23247704 chr1:116518985 SLC22A15 -0.72 -6.14 -0.32 2.42e-9 Cognitive function; CRC cis rs561341 1.000 rs1681718 chr17:30296445 G/A cg00745463 chr17:30367425 LRRC37B -0.9 -9.89 -0.48 2.27e-20 Hip circumference adjusted for BMI; CRC trans rs4965598 0.957 rs12901204 chr15:100756407 A/G cg05653646 chr5:139173162 NA -0.47 -6.17 -0.32 2e-9 Height; CRC trans rs2303319 0.504 rs62188988 chr2:162531068 T/C cg04269497 chr6:167369491 RNASET2 -0.71 -5.99 -0.31 5.49e-9 Cognitive function; CRC cis rs2836974 0.965 rs2836965 chr21:40633631 C/G cg11644478 chr21:40555479 PSMG1 -0.79 -11.78 -0.54 5.82e-27 Cognitive function; CRC cis rs13118159 0.573 rs7664763 chr4:1352305 A/G cg05025164 chr4:1340916 KIAA1530 0.62 8.97 0.44 2.37e-17 Longevity; CRC cis rs459193 1.000 rs458741 chr5:55807837 T/C cg00049729 chr5:55776345 NA 0.39 5.83 0.31 1.31e-8 Coronary artery disease;Type 2 diabetes;Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);Waist-to-hip ratio adjusted for BMI in non-smokers;Waist-to-hip ratio adjusted for BMI (smoking interaction);Waist-to-hip ratio adjusted for body mass index;Waist-hip ratio;Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction); CRC cis rs7659604 0.676 rs6534323 chr4:122695888 G/A cg20573242 chr4:122745356 CCNA2 0.49 7.12 0.37 6.64e-12 Type 2 diabetes; CRC cis rs62064224 0.509 rs2302276 chr17:30791503 C/T cg09324608 chr17:30823087 MYO1D 0.34 5.86 0.31 1.14e-8 Schizophrenia; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg20272604 chr1:231004631 C1orf198 0.39 6.28 0.33 1.06e-9 Liver disease severity in Alagille syndrome; CRC cis rs6831352 1.000 rs1126671 chr4:100048414 T/C cg13256891 chr4:100009986 ADH5 0.61 8.71 0.43 1.48e-16 Alcohol dependence; CRC cis rs28386778 0.897 rs894413 chr17:61916347 A/G cg07362569 chr17:61921086 SMARCD2 0.38 5.83 0.31 1.3e-8 Prudent dietary pattern; CRC cis rs10504229 0.728 rs77197419 chr8:58150879 C/A cg02290350 chr8:58132656 NA -0.51 -6.57 -0.34 1.98e-10 Developmental language disorder (linguistic errors); CRC cis rs9479482 0.967 rs9479478 chr6:150354608 T/G cg25797454 chr6:150327115 RAET1K 0.35 6.09 0.32 3.22e-9 Alopecia areata; CRC cis rs798554 0.723 rs798518 chr7:2777825 A/G cg17321639 chr7:2759063 NA -0.42 -5.85 -0.31 1.17e-8 Height; CRC cis rs6502050 0.805 rs4356529 chr17:80157797 A/G cg19223190 chr17:80058835 NA -0.4 -6.41 -0.33 5.14e-10 Life satisfaction; CRC cis rs832540 0.931 rs1466008 chr5:56213406 G/C cg24531977 chr5:56204891 C5orf35 -0.48 -7.43 -0.38 9.71e-13 Coronary artery disease; CRC cis rs4073416 0.508 rs2898818 chr14:65972584 G/C cg03016385 chr14:66212404 NA -0.42 -5.93 -0.31 7.71e-9 N-glycan levels; CRC cis rs28386778 1.000 rs3020613 chr17:61955983 A/G cg22520471 chr17:61851767 DDX42;CCDC47 0.72 11.21 0.53 6.19e-25 Prudent dietary pattern; CRC cis rs1355223 0.583 rs2116085 chr11:34884001 C/A cg24088639 chr11:34937564 PDHX;APIP -0.6 -8.64 -0.43 2.47e-16 Systemic lupus erythematosus and Systemic sclerosis; CRC cis rs9341808 0.667 rs2322632 chr6:80845608 G/A cg08355045 chr6:80787529 NA 0.33 5.77 0.3 1.85e-8 Sitting height ratio; CRC cis rs6088590 1.000 rs6087625 chr20:33342477 A/G cg24642439 chr20:33292090 TP53INP2 -0.57 -10.55 -0.5 1.32e-22 Coronary artery disease; CRC cis rs7937682 0.883 rs490492 chr11:111465150 C/T cg09085632 chr11:111637200 PPP2R1B -0.94 -17.74 -0.7 7.01e-50 Primary sclerosing cholangitis; CRC cis rs6752107 1.000 rs6752107 chr2:234161448 C/T cg07618928 chr2:234183455 ATG16L1;SCARNA5 0.64 11.08 0.52 1.9e-24 Crohn's disease;Inflammatory bowel disease; CRC cis rs13108904 0.870 rs4974542 chr4:1250908 A/G cg23123621 chr4:1343375 KIAA1530 0.32 5.64 0.3 3.65e-8 Obesity-related traits; CRC cis rs4076764 1.000 rs7525643 chr1:163426283 G/A cg06092702 chr1:163392909 NA -0.57 -8.89 -0.44 3.97e-17 Motion sickness; CRC cis rs6912958 0.781 rs4707376 chr6:88270947 A/G cg12350822 chr6:88032061 C6orf162;GJB7 -0.34 -6.32 -0.33 8.54e-10 Monocyte percentage of white cells; CRC cis rs3003334 1 rs3003334 chr1:24199869 G/A cg10978503 chr1:24200527 CNR2 0.62 11.26 0.53 4.43e-25 Eosinophil percentage of white cells;Eosinophil percentage of granulocytes; CRC cis rs1862618 0.853 rs252910 chr5:56192983 G/A cg12311346 chr5:56204834 C5orf35 -0.83 -10.33 -0.49 7.46e-22 Initial pursuit acceleration; CRC cis rs12711979 0.765 rs13030772 chr2:3821280 T/C cg17052675 chr2:3827356 NA -0.57 -10.83 -0.51 1.38e-23 Itch intensity from mosquito bite adjusted by bite size; CRC cis rs35306767 0.623 rs72760941 chr10:1141244 A/G cg20503657 chr10:835505 NA 0.7 8.24 0.41 4.05e-15 Eosinophil percentage of granulocytes; CRC cis rs12711979 0.509 rs10181286 chr2:3824567 G/A cg17052675 chr2:3827356 NA -0.86 -21.11 -0.76 3.77e-63 Itch intensity from mosquito bite adjusted by bite size; CRC cis rs4481887 0.502 rs4916108 chr1:248360633 G/A cg00666640 chr1:248458726 OR2T12 0.44 7.07 0.36 9.39e-12 Common traits (Other); CRC cis rs8060686 0.641 rs3785109 chr16:68118311 G/A cg26727032 chr16:67993705 SLC12A4 -0.58 -6.69 -0.35 9.85e-11 HDL cholesterol;Metabolic syndrome; CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg01117833 chr14:94547303 DDX24;IFI27L1 0.39 6.1 0.32 2.92e-9 Obesity-related traits; CRC cis rs12594515 1.000 rs8038320 chr15:45990267 G/C cg01629716 chr15:45996671 NA 0.41 8.46 0.42 9.03e-16 Waist circumference;Weight; CRC cis rs9430161 0.579 rs10864486 chr1:11040979 A/G cg02454025 chr1:11042201 C1orf127 0.9 14.34 0.62 1.46e-36 Ewing sarcoma; CRC cis rs523522 0.962 rs10849754 chr12:120940418 A/C cg12219531 chr12:120966889 COQ5 0.69 9.28 0.46 2.36e-18 High light scatter reticulocyte count; CRC cis rs67478160 0.619 rs12437066 chr14:104236844 A/C cg01849466 chr14:104193079 ZFYVE21 -0.56 -10.47 -0.5 2.58e-22 Schizophrenia; CRC cis rs6831352 0.879 rs29001208 chr4:100052539 A/C cg12011299 chr4:100065546 ADH4 -0.48 -8.85 -0.44 5.64e-17 Alcohol dependence; CRC cis rs1448094 0.512 rs6539933 chr12:86247611 T/C cg19622623 chr12:86230825 RASSF9 -0.41 -6.74 -0.35 7.23e-11 Major depressive disorder; CRC trans rs2797369 0.882 rs2764271 chr6:101651617 A/T cg26346621 chr12:6873348 NA -0.4 -6.26 -0.33 1.2e-9 Renal function-related traits (eGRFcrea); CRC cis rs9322193 0.962 rs9505974 chr6:150100430 C/T cg04369109 chr6:150039330 LATS1 -0.43 -6.01 -0.31 4.85e-9 Lung cancer; CRC cis rs6500395 0.926 rs1039342 chr16:48577498 G/A cg04672837 chr16:48644449 N4BP1 0.45 6.6 0.34 1.63e-10 Response to tocilizumab in rheumatoid arthritis; CRC cis rs1801251 0.778 rs2675967 chr2:233736133 C/G cg25237894 chr2:233734115 C2orf82 -0.63 -10.58 -0.5 1e-22 Coronary artery disease; CRC cis rs3806843 0.966 rs2563267 chr5:140136913 C/T cg19875535 chr5:140030758 IK -0.59 -9.67 -0.47 1.2e-19 Depressive symptoms (multi-trait analysis); CRC cis rs2404602 0.692 rs10444858 chr15:76962504 T/C cg03037974 chr15:76606532 NA 0.7 12.57 0.57 7.07e-30 Blood metabolite levels; CRC cis rs7605827 0.897 rs10432400 chr2:15667324 T/C cg19274914 chr2:15703543 NA 0.37 5.7 0.3 2.62e-8 Educational attainment (years of education); CRC cis rs2439831 0.850 rs8023458 chr15:44080939 C/T cg02155558 chr15:43621948 ADAL;LCMT2 0.66 7.08 0.36 8.77e-12 Lung cancer in ever smokers; CRC cis rs62229266 0.804 rs2255858 chr21:37412752 T/C cg08632701 chr21:37451849 NA -0.45 -7.07 -0.36 9.09e-12 Mitral valve prolapse; CRC trans rs875971 0.660 rs2191268 chr7:66110224 C/T cg25199208 chr2:109402912 CCDC138 -0.4 -6.46 -0.34 3.79e-10 Aortic root size; CRC cis rs713477 0.967 rs10483642 chr14:55920460 A/G cg13175173 chr14:55914753 NA 0.45 8.5 0.42 6.71e-16 Pediatric bone mineral content (femoral neck); CRC trans rs2727020 0.729 rs1917325 chr11:49370004 G/A cg21153622 chr11:89784906 NA -0.41 -6.83 -0.35 4.16e-11 Coronary artery disease; CRC trans rs1455244 0.700 rs7229302 chr18:11508904 G/T cg23120805 chr2:43453872 LOC100129726;ZFP36L2 0.42 6.72 0.35 8.04e-11 Schizophrenia; CRC cis rs736408 0.648 rs3774355 chr3:52817778 G/A cg11645453 chr3:52864694 ITIH4 0.39 6.64 0.34 1.26e-10 Bipolar disorder; CRC cis rs7647973 0.710 rs6446285 chr3:49626306 G/A cg13072238 chr3:49761600 GMPPB -0.57 -5.81 -0.31 1.46e-8 Menarche (age at onset); CRC cis rs2952156 0.920 rs1018246 chr17:37835240 C/T cg11212589 chr17:38028394 ZPBP2 0.34 6.05 0.32 3.94e-9 Asthma; CRC cis rs7772486 0.875 rs2814863 chr6:146347299 C/T cg23711669 chr6:146136114 FBXO30 -0.67 -11.75 -0.54 7.55e-27 Lobe attachment (rater-scored or self-reported); CRC cis rs2228479 0.850 rs17226966 chr16:89825338 A/G cg06558623 chr16:89946397 TCF25 1.13 10.45 0.5 2.85e-22 Skin colour saturation; CRC trans rs61931739 0.517 rs2636073 chr12:34063049 C/T cg26384229 chr12:38710491 ALG10B 0.51 7.01 0.36 1.36e-11 Morning vs. evening chronotype; CRC cis rs2276314 0.802 rs9963714 chr18:33592056 T/C cg19628046 chr18:33552617 C18orf21 0.55 7.15 0.37 5.71e-12 Endometriosis;Drug-induced torsades de pointes; CRC cis rs6840360 0.571 rs17275577 chr4:152519899 G/A cg09659197 chr4:152720779 NA 0.31 5.69 0.3 2.77e-8 Intelligence (multi-trait analysis); CRC cis rs2204008 0.570 rs1315664 chr12:38138274 A/G cg26384229 chr12:38710491 ALG10B -0.55 -8.21 -0.41 5.21e-15 Bladder cancer; CRC cis rs7703744 0.681 rs11957102 chr5:118701899 G/T cg23917399 chr5:118691751 TNFAIP8 0.42 5.72 0.3 2.46e-8 Lobe attachment (rater-scored or self-reported); CRC cis rs1799949 1.000 rs8176242 chr17:41217874 C/T cg23758822 chr17:41437982 NA 0.81 13.52 0.6 2.04e-33 Menopause (age at onset); CRC cis rs12142240 0.698 rs67142569 chr1:46828460 C/T cg00530320 chr1:46809349 NSUN4 0.59 8.11 0.41 1.02e-14 Menopause (age at onset); CRC cis rs9926296 0.585 rs8045232 chr16:89857548 A/G cg03388025 chr16:89894329 SPIRE2 0.41 8.08 0.41 1.28e-14 Vitiligo; CRC cis rs11098499 0.615 rs28551750 chr4:120264901 C/T cg09307838 chr4:120376055 NA 0.61 9.54 0.47 3.35e-19 Corneal astigmatism; CRC cis rs12143943 0.966 rs11240762 chr1:204566999 C/T cg17419461 chr1:204415978 PIK3C2B 0.37 5.75 0.3 2e-8 Cognitive performance; CRC cis rs9894429 0.646 rs8080391 chr17:79566319 A/T cg21984481 chr17:79567631 NPLOC4 0.57 10.79 0.51 2.01e-23 Eye color traits; CRC cis rs853679 0.517 rs4713146 chr6:28111536 A/T cg23161317 chr6:28129485 ZNF389 0.53 6.43 0.33 4.52e-10 Depression; CRC cis rs6860806 0.507 rs272854 chr5:131688017 C/T cg24060327 chr5:131705240 SLC22A5 -0.54 -8.05 -0.41 1.56e-14 Breast cancer; CRC cis rs6479527 0.840 rs2094927 chr9:96765386 C/A cg14459158 chr9:96720562 NA 0.41 7.4 0.38 1.16e-12 Esophageal adenocarcinoma; CRC cis rs644799 0.623 rs17207890 chr11:95490754 C/T cg03916912 chr11:95522834 CEP57;FAM76B 0.75 11.38 0.53 1.56e-25 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs7586879 0.616 rs13410999 chr2:25097939 T/C cg04586622 chr2:25135609 ADCY3 -0.56 -10.45 -0.5 2.87e-22 Body mass index; CRC cis rs4927850 1.000 rs7630875 chr3:195753766 A/G cg01181863 chr3:195395398 SDHAP2 -0.56 -7.88 -0.4 4.97e-14 Pancreatic cancer; CRC cis rs10504229 0.683 rs55807014 chr8:58131801 T/C cg24829409 chr8:58192753 C8orf71 -0.55 -8.03 -0.4 1.71e-14 Developmental language disorder (linguistic errors); CRC cis rs9457247 0.967 rs424185 chr6:167410907 C/T cg23791538 chr6:167370224 RNASET2 -0.39 -6.08 -0.32 3.37e-9 Crohn's disease; CRC cis rs270601 0.913 rs273916 chr5:131659830 C/A cg27615366 chr5:131592974 PDLIM4 0.34 5.88 0.31 1e-8 Acylcarnitine levels; CRC cis rs7613875 0.578 rs2526749 chr3:50076734 A/G cg24110177 chr3:50126178 RBM5 0.58 9.13 0.45 6.99e-18 Body mass index; CRC cis rs79349575 0.783 rs62075818 chr17:46982327 T/A cg22482690 chr17:47019901 SNF8 0.49 8.2 0.41 5.33e-15 Type 2 diabetes; CRC cis rs826838 0.616 rs4418873 chr12:38625473 C/A cg26384229 chr12:38710491 ALG10B 0.43 6.25 0.33 1.26e-9 Heart rate; CRC cis rs1018836 0.828 rs12548806 chr8:91564256 C/T cg16814680 chr8:91681699 NA -0.64 -9.86 -0.48 2.84e-20 Ejection fraction in Tripanosoma cruzi seropositivity; CRC cis rs3812762 0.826 rs2292045 chr11:8806709 G/T cg21881798 chr11:8931708 C11orf17;ST5 -0.41 -6.01 -0.31 4.84e-9 Hypospadias; CRC cis rs7940866 0.801 rs10894296 chr11:130840433 T/G cg12179176 chr11:130786555 SNX19 0.61 8.72 0.43 1.42e-16 Schizophrenia; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg23437166 chr4:13486582 RAB28 0.49 6.36 0.33 6.74e-10 Thyroid stimulating hormone; CRC cis rs6582630 0.555 rs10748382 chr12:38504529 C/T cg13010199 chr12:38710504 ALG10B 0.48 6.36 0.33 6.84e-10 Drug-induced liver injury (flucloxacillin); CRC cis rs7208859 0.623 rs28433704 chr17:29084285 G/C cg13385521 chr17:29058706 SUZ12P 0.73 8.33 0.42 2.14e-15 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs10504229 0.593 rs2317990 chr8:58024168 G/T cg02290350 chr8:58132656 NA -0.46 -5.84 -0.31 1.24e-8 Developmental language disorder (linguistic errors); CRC cis rs769267 0.566 rs9304962 chr19:19679992 G/C cg03709012 chr19:19516395 GATAD2A -0.54 -7.25 -0.37 2.92e-12 Tonsillectomy; CRC cis rs7927592 0.956 rs6591341 chr11:68335478 C/T cg01657329 chr11:68192670 LRP5 -0.52 -8.11 -0.41 1.03e-14 Total body bone mineral density; CRC cis rs9783347 0.961 rs4150526 chr11:18343209 G/A cg15585147 chr11:18324498 HPS5 0.45 6.34 0.33 7.44e-10 Pancreatic cancer; CRC cis rs7223966 0.921 rs3020612 chr17:61960878 C/T cg23090583 chr17:61904693 PSMC5;FTSJ3 0.46 5.74 0.3 2.17e-8 Hip circumference adjusted for BMI;Body mass index; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg07369507 chr6:28304287 ZNF323 0.45 6.96 0.36 1.85e-11 Liver disease severity in Alagille syndrome; CRC cis rs7172677 0.768 rs2304901 chr15:75340722 G/A cg14664628 chr15:75095509 CSK 0.55 6.5 0.34 3.05e-10 Systemic lupus erythematosus and Systemic sclerosis; CRC trans rs2727020 0.521 rs937430 chr11:49542457 A/G cg15704280 chr7:45808275 SEPT13 0.77 10.37 0.5 5.34e-22 Coronary artery disease; CRC cis rs11123170 0.640 rs2863240 chr2:113970116 C/T cg11763394 chr2:113992921 PAX8;LOC440839;LOC654433 -0.56 -7.52 -0.38 5.11e-13 Renal function-related traits (BUN); CRC cis rs9611519 0.894 rs9611486 chr22:41458784 C/G cg03806693 chr22:41940476 POLR3H -0.58 -7.36 -0.38 1.49e-12 Neuroticism; CRC cis rs6502050 0.835 rs12950475 chr17:80118924 T/C cg25804541 chr17:80189381 SLC16A3 -0.31 -5.95 -0.31 6.84e-9 Life satisfaction; CRC cis rs10927875 0.518 rs732286 chr1:16344360 A/G cg24140574 chr1:16342155 HSPB7 0.47 6.62 0.34 1.44e-10 Dilated cardiomyopathy; CRC cis rs11212617 0.935 rs11212543 chr11:108054922 G/A cg01991180 chr11:108092276 ATM;NPAT 0.41 6.01 0.31 4.79e-9 Response to metformin in type 2 diabetes (glycemic); CRC cis rs2249625 0.564 rs2463734 chr6:72882558 C/T cg18830697 chr6:72922368 RIMS1 -0.39 -7.87 -0.4 5.03e-14 Acute urticaria and angioedema (non-steroidal anti-inflammatory drug-induced); CRC cis rs4481887 0.790 rs4382760 chr1:248422343 A/C cg00666640 chr1:248458726 OR2T12 -0.49 -8.33 -0.42 2.22e-15 Common traits (Other); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg04200765 chr15:73925532 NPTN 0.44 6.33 0.33 8.07e-10 Intelligence (multi-trait analysis); CRC cis rs2204008 0.688 rs12824232 chr12:38175901 G/A cg13010199 chr12:38710504 ALG10B 0.45 5.74 0.3 2.1e-8 Bladder cancer; CRC cis rs2836974 0.899 rs2836957 chr21:40623134 T/C cg11890956 chr21:40555474 PSMG1 1.11 19.23 0.73 9.17e-56 Cognitive function; CRC cis rs12681288 0.823 rs2701908 chr8:1003250 T/C cg15309053 chr8:964076 NA 0.37 6.55 0.34 2.18e-10 Schizophrenia; CRC cis rs62458065 1.000 rs6462363 chr7:32464759 T/G cg20159608 chr7:32802032 NA -0.49 -6.2 -0.32 1.68e-9 Metabolite levels (HVA/MHPG ratio); CRC cis rs7605378 0.528 rs281767 chr2:200823281 C/A cg23649088 chr2:200775458 C2orf69 0.7 11.18 0.52 8.35e-25 Osteoporosis; CRC cis rs12477438 0.520 rs11689265 chr2:99799267 A/G cg26064155 chr2:99771622 LIPT1;TSGA10 0.89 16.27 0.67 4.32e-44 Chronic sinus infection; CRC cis rs2777491 0.507 rs11854081 chr15:41646398 C/T cg18705301 chr15:41695430 NDUFAF1 -1.11 -19.47 -0.73 1.07e-56 Ulcerative colitis; CRC cis rs7904368 0.806 rs45495501 chr10:16861476 G/A cg14835575 chr10:16859367 RSU1 0.47 6.3 0.33 9.61e-10 Ratio of the peak velocity of the mitral E-Wave divided by the peak velocity of the mitral A-wave.; CRC cis rs7613875 0.600 rs2624826 chr3:50155468 T/G cg24110177 chr3:50126178 RBM5 0.55 8.32 0.42 2.45e-15 Body mass index; CRC cis rs6066835 0.764 rs6066843 chr20:47372817 C/G cg18078177 chr20:47281410 PREX1 0.69 5.92 0.31 8.29e-9 Multiple myeloma; CRC cis rs1127311 0.846 rs61811388 chr1:154581231 G/C cg17218026 chr1:154582156 ADAR 0.67 11.32 0.53 2.64e-25 C-reactive protein levels or triglyceride levels (pleiotropy); CRC cis rs910187 0.678 rs6124965 chr20:45812957 T/G cg27589058 chr20:45804311 EYA2 -0.38 -7.3 -0.37 2.12e-12 Migraine; CRC cis rs9612 1.000 rs16976747 chr19:44238152 G/A cg08581076 chr19:44259116 C19orf61 0.53 6.62 0.34 1.42e-10 Exhaled nitric oxide output; CRC cis rs7607369 0.626 rs4672892 chr2:219278630 A/G cg02176678 chr2:219576539 TTLL4 -0.6 -8.81 -0.44 7.21e-17 Red blood cell count;Amyotrophic lateral sclerosis; CRC cis rs853679 0.517 rs9380056 chr6:28104476 C/T cg21251018 chr6:28226885 NKAPL 0.48 6.33 0.33 7.86e-10 Depression; CRC cis rs832540 0.629 rs3309 chr5:56092779 A/T cg20203395 chr5:56204925 C5orf35 0.42 5.86 0.31 1.11e-8 Coronary artery disease; CRC cis rs4713118 0.513 rs200971 chr6:27858904 C/T cg25164649 chr6:28176230 NA 0.57 7.84 0.4 6.42e-14 Parkinson's disease; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg02340915 chr12:121904480 KDM2B 0.43 6.88 0.35 3.05e-11 Liver disease severity in Alagille syndrome; CRC cis rs9430161 0.644 rs34365965 chr1:11034442 G/A cg27631724 chr1:11040367 C1orf127 0.32 6.39 0.33 5.73e-10 Ewing sarcoma; CRC cis rs9916302 0.706 rs6503504 chr17:37514412 A/G cg07936489 chr17:37558343 FBXL20 0.91 11.42 0.53 1.15e-25 Glomerular filtration rate (creatinine); CRC cis rs7680126 0.633 rs11728093 chr4:10296407 A/C cg00071950 chr4:10020882 SLC2A9 -0.52 -6.68 -0.35 1.01e-10 Urate levels in lean individuals;Urate levels in overweight individuals;Urate levels in obese individuals; CRC cis rs7998202 0.667 rs665813 chr13:113355765 A/G cg02820901 chr13:113351484 ATP11A 0.61 6.65 0.34 1.2e-10 Glycated hemoglobin levels; CRC cis rs35520189 0.556 rs11893071 chr2:113708790 T/A cg12858261 chr2:113808755 IL1F8 0.47 6.3 0.33 9.67e-10 Obstructive sleep apnea trait (apnea hypopnea index); CRC cis rs1190596 0.567 rs36060205 chr14:102719697 G/C cg04767283 chr14:102695768 RAGE -0.44 -5.64 -0.3 3.75e-8 Behavioural disinhibition (generation interaction); CRC cis rs853679 0.517 rs2281588 chr6:28072602 G/A cg06470822 chr6:28175283 NA 1.0 13.31 0.59 1.27e-32 Depression; CRC cis rs3820068 0.626 rs61103742 chr1:15909153 A/C cg13390004 chr1:15929781 NA 0.45 5.95 0.31 6.93e-9 Systolic blood pressure; CRC cis rs9903692 0.954 rs1860866 chr17:46201031 C/T cg21215337 chr17:46176117 CBX1 -0.43 -7.94 -0.4 3.33e-14 Pulse pressure; CRC cis rs9389248 0.737 rs56358308 chr6:135306980 A/T cg22676075 chr6:135203613 NA 0.59 8.92 0.44 3.38e-17 High light scatter reticulocyte percentage of red cells; CRC cis rs7615952 0.599 rs2270986 chr3:125701099 T/C cg02807482 chr3:125708958 NA -0.46 -5.9 -0.31 9.13e-9 Blood pressure (smoking interaction); CRC cis rs4561483 0.801 rs33619 chr16:12008941 T/G cg08843971 chr16:11963173 GSPT1 -0.63 -9.75 -0.47 6.74e-20 Testicular germ cell tumor; CRC cis rs8038465 0.622 rs60696711 chr15:73873005 C/A cg15420318 chr15:73925796 NPTN 0.44 7.04 0.36 1.1e-11 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs853679 0.517 rs9393897 chr6:28127710 G/T cg12273811 chr6:28175739 NA 0.73 9.16 0.45 5.8e-18 Depression; CRC cis rs9733 0.519 rs7529194 chr1:150622620 A/T cg18016565 chr1:150552671 MCL1 0.43 6.42 0.33 4.9e-10 Tonsillectomy; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg26203883 chr20:36156320 BLCAP 0.37 6.25 0.33 1.31e-9 Liver disease severity in Alagille syndrome; CRC cis rs8180040 0.966 rs6792488 chr3:47503349 C/T cg10298567 chr3:47292165 KIF9 0.37 6.03 0.32 4.37e-9 Colorectal cancer; CRC cis rs2976388 0.590 rs3758082 chr8:143824483 A/G cg05569086 chr8:143859399 LYNX1 -0.39 -6.43 -0.33 4.54e-10 Urinary tract infection frequency; CRC trans rs9650657 0.615 rs11996727 chr8:10691489 C/T cg06636001 chr8:8085503 FLJ10661 -0.4 -5.97 -0.31 6.23e-9 Neuroticism; CRC cis rs11674184 0.525 rs4669755 chr2:11748585 A/C cg07314298 chr2:11723111 GREB1 0.38 6.08 0.32 3.29e-9 Endometriosis; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg18756060 chr2:27294719 LOC100128731 0.41 6.11 0.32 2.87e-9 Response to antipsychotic treatment; CRC cis rs11190604 1.000 rs2295772 chr10:102265183 G/A cg16342193 chr10:102329863 NA -0.36 -6.05 -0.32 3.85e-9 Palmitoleic acid (16:1n-7) levels; CRC cis rs7618915 0.547 rs13085895 chr3:52678270 G/C cg11645453 chr3:52864694 ITIH4 0.36 6.25 0.33 1.29e-9 Bipolar disorder; CRC cis rs2625529 0.526 rs7179942 chr15:72563074 C/G cg16672083 chr15:72433130 SENP8 0.45 6.87 0.35 3.25e-11 Red blood cell count; CRC cis rs8103278 0.507 rs4802275 chr19:46260375 C/T cg02376097 chr19:46275166 DMPK 0.38 5.98 0.31 5.66e-9 Coronary artery disease; CRC cis rs875971 0.862 rs778734 chr7:65814849 C/G cg00343986 chr7:65444356 GUSB 0.4 5.66 0.3 3.31e-8 Aortic root size; CRC cis rs9910055 0.573 rs228768 chr17:42191893 A/C cg09913183 chr17:42254507 C17orf65;ASB16 0.47 6.54 0.34 2.31e-10 Total body bone mineral density; CRC cis rs7586879 0.828 rs1077641 chr2:25123665 G/A cg04586622 chr2:25135609 ADCY3 -0.56 -9.47 -0.46 5.84e-19 Body mass index; CRC cis rs769267 0.965 rs4808938 chr19:19401218 G/A cg03709012 chr19:19516395 GATAD2A 0.71 10.97 0.52 4.39e-24 Tonsillectomy; CRC trans rs4942242 0.602 rs61960076 chr13:44217784 T/C cg19169023 chr15:41853346 TYRO3 -0.58 -8.11 -0.41 1.03e-14 Response to tocilizumab in rheumatoid arthritis; CRC cis rs317689 0.513 rs317678 chr12:69692166 C/G cg20891283 chr12:69753455 YEATS4 0.69 10.96 0.52 4.89e-24 Response to diuretic therapy; CRC trans rs208520 1.000 rs12199876 chr6:66989469 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.89 10.9 0.52 8.03e-24 Exhaled nitric oxide output; CRC cis rs1448094 0.791 rs10863110 chr12:86328523 T/C cg18827107 chr12:86230957 RASSF9 -0.42 -6.62 -0.34 1.48e-10 Major depressive disorder; CRC cis rs7246657 1.000 rs7247672 chr19:37743928 A/G cg23950597 chr19:37808831 NA -0.54 -6.25 -0.33 1.3e-9 Coronary artery calcification; CRC cis rs6582630 0.555 rs1969362 chr12:38514843 C/T cg26384229 chr12:38710491 ALG10B 0.69 9.76 0.47 6.14e-20 Drug-induced liver injury (flucloxacillin); CRC cis rs2976388 1.000 rs10216533 chr8:143763690 G/A cg20041105 chr8:143859282 LYNX1 -0.32 -5.71 -0.3 2.59e-8 Urinary tract infection frequency; CRC cis rs3749237 0.636 rs1568662 chr3:49521263 A/G cg03060546 chr3:49711283 APEH 0.69 11.95 0.55 1.36e-27 Resting heart rate; CRC cis rs7666738 0.791 rs7678564 chr4:99057341 A/G cg17366294 chr4:99064904 C4orf37 0.45 7.68 0.39 1.83e-13 Colonoscopy-negative controls vs population controls; CRC cis rs34638657 0.500 rs1056675 chr16:82181934 T/C cg07918374 chr16:82182319 MPHOSPH6 0.41 5.66 0.3 3.29e-8 Lung adenocarcinoma; CRC cis rs6570726 0.791 rs414600 chr6:145879606 G/A cg05347473 chr6:146136440 FBXO30 0.4 6.07 0.32 3.45e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs12612619 0.732 rs11681562 chr2:27250603 A/G cg00617064 chr2:27272375 NA -0.35 -5.9 -0.31 9.04e-9 Venous thromboembolism adjusted for sickle cell variant rs77121243-T; CRC cis rs28386778 0.897 rs9912557 chr17:61784963 C/A cg25654072 chr17:61904446 PSMC5;FTSJ3 0.73 11.24 0.53 5.23e-25 Prudent dietary pattern; CRC cis rs13118159 0.550 rs13123016 chr4:1340889 T/C cg05025164 chr4:1340916 KIAA1530 0.6 8.39 0.42 1.49e-15 Longevity; CRC cis rs9513627 0.573 rs4771336 chr13:100210610 T/G cg09676794 chr13:100310162 CLYBL 0.44 6.03 0.32 4.42e-9 Obesity-related traits; CRC cis rs11764590 0.671 rs56226325 chr7:2078981 C/T cg02825527 chr7:2087843 MAD1L1 -0.48 -5.7 -0.3 2.68e-8 Neuroticism; CRC cis rs1577917 0.958 rs2225754 chr6:86449698 G/A cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.64 -8.08 -0.41 1.27e-14 Response to antipsychotic treatment; CRC cis rs1218582 0.772 rs10796934 chr1:154849479 C/G cg03351412 chr1:154909251 PMVK 0.53 8.53 0.43 5.59e-16 Prostate cancer; CRC cis rs7827545 1.000 rs1372660 chr8:135566788 C/G cg07299736 chr8:135490787 ZFAT -0.38 -6.42 -0.33 4.65e-10 Hypertension (SNP x SNP interaction); CRC cis rs172166 0.637 rs1225597 chr6:28162087 C/T cg17949981 chr6:28129498 ZNF389 0.4 5.6 0.3 4.43e-8 Cardiac Troponin-T levels; CRC cis rs9534288 0.797 rs718530 chr13:46563653 T/C cg15192986 chr13:46630673 CPB2 -0.68 -9.8 -0.48 4.54e-20 Blood protein levels; CRC cis rs4665809 0.887 rs28699126 chr2:26357294 C/T cg27170947 chr2:26402098 FAM59B -0.46 -6.22 -0.32 1.51e-9 Gut microbiome composition (summer); CRC trans rs1590305 0.786 rs73180681 chr13:38059979 C/T cg03965764 chr11:45248109 NA -0.59 -6.08 -0.32 3.35e-9 Hip geometry; CRC trans rs13046373 0.905 rs4816372 chr21:32077414 A/T cg03822858 chr10:4066499 NA -0.4 -6.12 -0.32 2.68e-9 HDL cholesterol; CRC cis rs10504229 1.000 rs68112919 chr8:58188247 G/A cg24829409 chr8:58192753 C8orf71 -0.68 -11.25 -0.53 4.62e-25 Developmental language disorder (linguistic errors); CRC cis rs8072100 1.000 rs3809868 chr17:45750596 G/A cg25173405 chr17:45401733 C17orf57 0.47 7.2 0.37 4.04e-12 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs1971762 0.545 rs11170632 chr12:54047935 C/T cg06632207 chr12:54070931 ATP5G2 -0.49 -8.55 -0.43 4.55e-16 Height; CRC cis rs826838 0.935 rs1160162 chr12:38959795 G/A cg13010199 chr12:38710504 ALG10B 0.44 5.67 0.3 3.13e-8 Heart rate; CRC cis rs1448094 0.511 rs61930582 chr12:86157387 T/C cg06740227 chr12:86229804 RASSF9 0.38 5.7 0.3 2.73e-8 Major depressive disorder; CRC cis rs11711311 0.866 rs13313893 chr3:113400856 A/G cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.5 -6.59 -0.34 1.8e-10 IgG glycosylation; CRC cis rs7605827 0.893 rs6734024 chr2:15718180 A/G cg19274914 chr2:15703543 NA 0.39 5.85 0.31 1.2e-8 Educational attainment (years of education); CRC cis rs2160860 0.773 rs7003411 chr8:39800461 A/G cg11363097 chr8:39792086 IDO2 -0.45 -7.66 -0.39 2.12e-13 Blood metabolite levels; CRC cis rs801193 0.904 rs4718403 chr7:66242729 C/G cg18876405 chr7:65276391 NA 0.59 10.46 0.5 2.73e-22 Aortic root size; CRC cis rs754466 0.958 rs11002341 chr10:79701363 A/C cg17075019 chr10:79541650 NA -0.73 -10.27 -0.49 1.17e-21 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs3126085 0.877 rs1552992 chr1:152171625 C/G cg09127314 chr1:152161683 NA 0.53 6.87 0.35 3.25e-11 Atopic dermatitis; CRC cis rs2836974 0.965 rs34578707 chr21:40675167 G/A cg11644478 chr21:40555479 PSMG1 0.68 9.63 0.47 1.65e-19 Cognitive function; CRC cis rs3806843 1.000 rs12055222 chr5:140165568 T/C cg16607685 chr5:140181889 PCDHA2;PCDHA1;PCDHA3 -0.27 -6.25 -0.33 1.25e-9 Depressive symptoms (multi-trait analysis); CRC cis rs73200209 0.912 rs57703342 chr12:116677337 C/G cg01776926 chr12:116560359 MED13L -0.48 -5.91 -0.31 8.58e-9 Total body bone mineral density; CRC cis rs2576037 0.544 rs629097 chr18:44378097 T/C cg23996704 chr18:44553084 KATNAL2 -0.31 -6.17 -0.32 2.05e-9 Personality dimensions; CRC cis rs1865760 0.566 rs9366634 chr6:26072396 C/G cg16482183 chr6:26056742 HIST1H1C 0.53 7.71 0.39 1.54e-13 Height; CRC cis rs1499614 1.000 rs2141924 chr7:66186246 C/T cg25985355 chr7:65971099 NA -0.52 -5.91 -0.31 8.41e-9 Gout; CRC cis rs3617 0.573 rs62253583 chr3:52928334 G/A cg15147215 chr3:52552868 STAB1 0.5 8.61 0.43 3.13e-16 Red blood cell count;Autism spectrum disorder or schizophrenia; CRC cis rs4789693 0.938 rs12952655 chr17:80421139 C/T cg04308225 chr17:80449738 NA -0.54 -7.39 -0.38 1.25e-12 Glucocorticoid-induced osteonecrosis; CRC cis rs17270561 1.000 rs12211184 chr6:25823774 G/A cg16482183 chr6:26056742 HIST1H1C 0.93 10.45 0.5 2.97e-22 Iron status biomarkers; CRC cis rs9814567 1.000 rs6765505 chr3:134208132 A/G cg06541857 chr3:134203789 ANAPC13;CEP63 -0.41 -6.2 -0.32 1.67e-9 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs4332037 0.722 rs4719332 chr7:1914681 G/A cg24505167 chr7:1915268 MAD1L1 -0.48 -7.31 -0.37 2.08e-12 Bipolar disorder; CRC cis rs28386778 0.897 rs2584608 chr17:61936710 A/G cg25654072 chr17:61904446 PSMC5;FTSJ3 0.67 10.01 0.48 8.89e-21 Prudent dietary pattern; CRC cis rs2239547 0.603 rs6805298 chr3:53096552 A/G cg18404041 chr3:52824283 ITIH1 0.35 6.48 0.34 3.37e-10 Schizophrenia; CRC cis rs990171 1.000 rs7603250 chr2:103068834 T/A cg03938978 chr2:103052716 IL18RAP 0.46 5.89 0.31 9.7e-9 Lymphocyte counts; CRC cis rs67311347 1.000 rs73078162 chr3:40477109 G/A cg24209194 chr3:40518798 ZNF619 0.42 5.9 0.31 9.18e-9 Renal cell carcinoma; CRC cis rs875971 0.545 rs73376401 chr7:65639828 G/A cg18876405 chr7:65276391 NA 0.45 6.39 0.33 5.64e-10 Aortic root size; CRC cis rs6835098 0.962 rs10014010 chr4:174083230 C/T cg08422745 chr4:174089978 GALNT7 -0.94 -15.72 -0.65 6.47e-42 Dementia and core Alzheimer's disease neuropathologic changes; CRC cis rs514406 0.793 rs12402415 chr1:53218539 G/T cg08859206 chr1:53392774 SCP2 0.41 6.63 0.34 1.36e-10 Monocyte count; CRC cis rs12477438 0.765 rs2309520 chr2:99570477 C/G cg14399236 chr2:99771627 LIPT1;TSGA10 0.59 8.2 0.41 5.42e-15 Chronic sinus infection; CRC cis rs747650 0.504 rs7938169 chr11:46971539 T/C cg19486271 chr11:47235900 DDB2 -0.43 -6.52 -0.34 2.72e-10 Acne (severe); CRC cis rs7998202 0.667 rs99126 chr13:113359336 C/G cg02820901 chr13:113351484 ATP11A -0.58 -6.35 -0.33 7.24e-10 Glycated hemoglobin levels; CRC trans rs875971 0.545 rs75840613 chr7:65841386 G/A cg02869306 chr7:64672164 INTS4L1 -0.44 -6.37 -0.33 6.44e-10 Aortic root size; CRC cis rs847649 0.732 rs56269620 chr7:102489456 A/G cg18108683 chr7:102477205 FBXL13 -0.65 -11.31 -0.53 2.76e-25 Morning vs. evening chronotype; CRC trans rs3733585 0.673 rs4312757 chr4:9956145 T/A cg26043149 chr18:55253948 FECH -0.5 -7.65 -0.39 2.23e-13 Cleft plate (environmental tobacco smoke interaction); CRC cis rs7605827 0.893 rs7589238 chr2:15606409 C/A cg19274914 chr2:15703543 NA 0.39 5.9 0.31 8.83e-9 Educational attainment (years of education); CRC trans rs4618210 0.722 rs1806555 chr3:17016794 G/T cg21880720 chr19:2163652 DOT1L 0.48 6.03 0.32 4.51e-9 Myocardial infarction; CRC trans rs916888 0.610 rs199530 chr17:44836653 C/T cg07870213 chr5:140052090 DND1 -0.61 -8.14 -0.41 8.48e-15 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs12134245 0.776 rs6688261 chr1:91987034 C/T cg13639937 chr1:92012655 NA -0.36 -6.11 -0.32 2.84e-9 Breast cancer; CRC cis rs9916302 0.706 rs8069074 chr17:37685401 C/T cg00129232 chr17:37814104 STARD3 0.55 6.75 0.35 6.89e-11 Glomerular filtration rate (creatinine); CRC cis rs57590327 0.503 rs7426937 chr3:81881360 T/C cg07356753 chr3:81810745 GBE1 -0.57 -7.67 -0.39 1.93e-13 Extraversion; CRC trans rs1360141 0.964 rs4745112 chr9:74292618 T/C cg07994661 chr4:153856847 NA 0.32 6.02 0.31 4.72e-9 Acute graft versus host disease in bone marrow transplantation (recipient effect); CRC cis rs1153858 1.000 rs4774578 chr15:45646051 G/A cg10760299 chr15:45669010 GATM 0.49 7.79 0.39 8.71e-14 Homoarginine levels; CRC cis rs11764590 0.543 rs55893771 chr7:2096255 C/T cg23422044 chr7:1970798 MAD1L1 -0.47 -5.61 -0.3 4.19e-8 Neuroticism; CRC cis rs10924970 0.967 rs12027832 chr1:235385934 A/G cg26050004 chr1:235667680 B3GALNT2 0.39 5.81 0.3 1.49e-8 Asthma; CRC cis rs2832191 0.716 rs1543652 chr21:30448000 G/C cg08807101 chr21:30365312 RNF160 0.71 11.53 0.54 4.48e-26 Dental caries; CRC cis rs4713118 0.513 rs149954 chr6:28035246 G/A cg10876282 chr6:28092338 ZSCAN16 0.47 6.44 0.33 4.36e-10 Parkinson's disease; CRC cis rs2404602 0.692 rs7169663 chr15:77192843 A/C cg03037974 chr15:76606532 NA 0.69 11.51 0.54 5.25e-26 Blood metabolite levels; CRC cis rs10463316 0.894 rs10476980 chr5:150764157 A/G cg03212797 chr5:150827313 SLC36A1 -0.5 -7.78 -0.39 9.23e-14 Metabolite levels (Pyroglutamine); CRC cis rs10927875 1.000 rs10927875 chr1:16299312 A/G cg22431228 chr1:16359049 CLCNKA -0.34 -6.17 -0.32 2.02e-9 Dilated cardiomyopathy; CRC cis rs9549328 0.800 rs9549326 chr13:113630453 C/T cg17524180 chr13:113633600 MCF2L -0.68 -12.77 -0.58 1.32e-30 Systolic blood pressure; CRC cis rs10504229 0.679 rs17800895 chr8:58050085 A/G cg24829409 chr8:58192753 C8orf71 -0.57 -7.13 -0.37 6.48e-12 Developmental language disorder (linguistic errors); CRC cis rs947211 1.000 rs823144 chr1:205744546 C/A cg14159672 chr1:205819179 PM20D1 0.42 5.68 0.3 2.89e-8 Parkinson's disease; CRC cis rs2732480 0.500 rs2732461 chr12:48692802 C/A cg24011408 chr12:48396354 COL2A1 0.45 6.18 0.32 1.92e-9 Hemoglobin concentration;Red blood cell count;Hematocrit; CRC cis rs4474465 0.850 rs10899551 chr11:78256998 A/C cg27205649 chr11:78285834 NARS2 -0.51 -6.68 -0.35 9.93e-11 Alzheimer's disease (survival time); CRC cis rs699 0.698 rs1326888 chr1:230863160 A/G cg07502417 chr1:230849801 AGT 0.28 5.7 0.3 2.71e-8 Coronary artery disease; CRC trans rs853679 0.760 rs9393910 chr6:28208192 C/G cg06606381 chr12:133084897 FBRSL1 -0.65 -6.7 -0.35 8.99e-11 Depression; CRC cis rs8060686 0.641 rs9932251 chr16:68131732 G/A cg08314208 chr16:67682810 RLTPR -0.49 -5.88 -0.31 1.01e-8 HDL cholesterol;Metabolic syndrome; CRC cis rs889312 0.500 rs252920 chr5:56148741 C/A cg12311346 chr5:56204834 C5orf35 -0.46 -6.98 -0.36 1.61e-11 Breast cancer;Breast cancer (early onset); CRC cis rs17767294 0.612 rs9461424 chr6:27919401 G/A cg15845792 chr6:28175446 NA 0.8 8.27 0.41 3.3e-15 Parkinson's disease; CRC cis rs4713118 0.662 rs9468278 chr6:28028482 C/T cg06470822 chr6:28175283 NA 0.95 13.56 0.6 1.43e-33 Parkinson's disease; CRC cis rs8180040 0.934 rs62260710 chr3:47564462 C/G cg27129171 chr3:47204927 SETD2 -0.62 -9.57 -0.47 2.57e-19 Colorectal cancer; CRC cis rs6502050 0.835 rs7502078 chr17:80131879 C/A cg13198984 chr17:80129470 CCDC57 0.45 7.82 0.4 7.07e-14 Life satisfaction; CRC cis rs9914988 0.943 rs11658884 chr17:27132742 A/G cg07195577 chr17:27052828 TLCD1 -0.42 -6.02 -0.31 4.78e-9 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs1003719 0.646 rs2032063 chr21:38576657 A/T cg10648535 chr21:38446584 PIGP;TTC3 -0.45 -6.23 -0.32 1.41e-9 Eye color traits; CRC cis rs116095464 0.558 rs55664502 chr5:270485 T/C cg22857025 chr5:266934 NA -1.18 -16.33 -0.67 2.61e-44 Breast cancer; CRC cis rs7208859 0.562 rs8078897 chr17:29106257 T/G cg01831904 chr17:28903510 LRRC37B2 -0.63 -6.53 -0.34 2.51e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs7811142 1.000 rs11766752 chr7:100073292 A/G cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.62 8.09 0.41 1.19e-14 Platelet count; CRC cis rs10504229 0.683 rs57866073 chr8:58139138 A/G cg02725872 chr8:58115012 NA -0.65 -10.98 -0.52 4.23e-24 Developmental language disorder (linguistic errors); CRC cis rs78456975 0.607 rs72776258 chr2:1530732 C/G cg01028140 chr2:1542097 TPO -0.6 -6.03 -0.32 4.39e-9 Placebo response in major depressive disorder (% change in symptom score); CRC cis rs2976388 0.556 rs10956985 chr8:143818750 C/A cg22687807 chr8:143858763 LYNX1 -0.45 -6.95 -0.36 1.95e-11 Urinary tract infection frequency; CRC cis rs9786986 0.665 rs10925942 chr1:235699585 C/T cg08848088 chr1:235714526 GNG4 0.56 6.51 0.34 2.84e-10 Body mass index; CRC cis rs2735413 0.918 rs4888731 chr16:78080418 A/G cg04733911 chr16:78082701 NA -0.44 -7.14 -0.37 5.83e-12 Systolic blood pressure (alcohol consumption interaction); CRC cis rs6484504 0.625 rs796341 chr11:31414151 G/A cg14844989 chr11:31128820 NA 0.33 5.83 0.31 1.33e-8 Red blood cell count; CRC cis rs6088580 0.570 rs6058057 chr20:33065283 G/A cg08999081 chr20:33150536 PIGU 0.61 11.44 0.53 9.47e-26 Glomerular filtration rate (creatinine); CRC cis rs10504229 0.683 rs58883273 chr8:58138275 A/G cg21724239 chr8:58056113 NA 0.49 6.81 0.35 4.75e-11 Developmental language disorder (linguistic errors); CRC trans rs703108 0.731 rs7898954 chr10:22323646 A/G cg23350446 chr6:170893182 PDCD2 -0.52 -6.06 -0.32 3.67e-9 Monocyte percentage of white cells; CRC cis rs10504229 0.679 rs17801003 chr8:58050930 A/G cg24829409 chr8:58192753 C8orf71 -0.57 -7.13 -0.37 6.48e-12 Developmental language disorder (linguistic errors); CRC cis rs7615952 0.932 rs3811679 chr3:125648283 A/G cg05084668 chr3:125655381 ALG1L -0.61 -9.2 -0.45 4.25e-18 Blood pressure (smoking interaction); CRC cis rs7937682 0.924 rs501089 chr11:111502479 G/T cg09085632 chr11:111637200 PPP2R1B 0.95 17.72 0.7 8.59e-50 Primary sclerosing cholangitis; CRC cis rs2637266 0.549 rs10824433 chr10:78412843 T/C cg18941641 chr10:78392320 NA -0.36 -5.95 -0.31 6.96e-9 Pulmonary function; CRC trans rs7618501 1.000 rs3811696 chr3:49761605 C/T cg21582582 chr3:182698605 DCUN1D1 -0.56 -8.26 -0.41 3.59e-15 Intelligence (multi-trait analysis); CRC trans rs4130344 0.935 rs11100197 chr4:159685743 C/T cg01113538 chr6:53658866 LRRC1 -0.4 -5.99 -0.31 5.56e-9 Intelligence (multi-trait analysis); CRC cis rs7107174 0.688 rs2063724 chr11:78133077 T/C cg02023728 chr11:77925099 USP35 0.36 6.01 0.31 4.89e-9 Testicular germ cell tumor; CRC cis rs801193 0.904 rs4718403 chr7:66242729 C/G cg00343986 chr7:65444356 GUSB 0.49 7.34 0.38 1.64e-12 Aortic root size; CRC cis rs1707322 0.686 rs2991977 chr1:46053683 G/A cg03146154 chr1:46216737 IPP -0.67 -9.64 -0.47 1.6e-19 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs10504229 0.683 rs58438731 chr8:58134790 C/T cg24829409 chr8:58192753 C8orf71 -0.55 -8.03 -0.4 1.71e-14 Developmental language disorder (linguistic errors); CRC cis rs7618915 0.571 rs17264436 chr3:52610651 T/A cg05573699 chr3:52720067 GNL3;PBRM1 -0.44 -6.23 -0.32 1.44e-9 Bipolar disorder; CRC cis rs7953249 0.656 rs1732391 chr12:121392341 C/T cg02403541 chr12:121454288 C12orf43 -0.45 -6.45 -0.34 3.96e-10 Invasive epithelial ovarian cancer;High-grade serous ovarian cancer;Chronic obstructive pulmonary disease-related biomarkers;N-glycan levels;Serous invasive ovarian cancer;Epithelial ovarian cancer; CRC cis rs9916302 0.904 rs2061342 chr17:37405657 T/G cg00129232 chr17:37814104 STARD3 -0.55 -8.07 -0.41 1.31e-14 Glomerular filtration rate (creatinine); CRC cis rs1862618 0.853 rs6450409 chr5:56101399 A/G cg24531977 chr5:56204891 C5orf35 -0.77 -10.29 -0.49 1.02e-21 Initial pursuit acceleration; CRC cis rs7666738 0.830 rs13148363 chr4:98847498 T/C cg17366294 chr4:99064904 C4orf37 0.4 6.48 0.34 3.34e-10 Colonoscopy-negative controls vs population controls; CRC cis rs77633900 0.772 rs2957607 chr15:76686527 A/G cg21673338 chr15:77095150 SCAPER 0.69 6.23 0.32 1.41e-9 Non-glioblastoma glioma;Glioma; CRC trans rs6703335 0.870 rs10803142 chr1:243598234 A/G cg02579316 chr6:126278500 HINT3 0.45 6.33 0.33 8.19e-10 Schizophrenia;Schizophrenia, schizoaffective disorder or bipolar disorder; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg11068520 chr14:50234443 KLHDC2 0.45 6.26 0.33 1.2e-9 Response to antipsychotic treatment; CRC cis rs11105298 0.891 rs1008764 chr12:89887649 T/C cg00757033 chr12:89920650 WDR51B 0.38 6.42 0.33 4.87e-10 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; CRC cis rs9916302 0.706 rs4332770 chr17:37704712 T/C cg07936489 chr17:37558343 FBXL20 -0.92 -11.97 -0.55 1.18e-27 Glomerular filtration rate (creatinine); CRC cis rs11650494 0.831 rs11650886 chr17:47449193 G/A cg08112188 chr17:47440006 ZNF652 1.19 11.18 0.52 8.1e-25 Prostate cancer; CRC trans rs2228479 0.850 rs17227263 chr16:89810598 G/A cg24644049 chr4:85504048 CDS1 0.9 7.41 0.38 1.05e-12 Skin colour saturation; CRC cis rs1451375 0.657 rs12665904 chr7:50635399 A/G cg18232548 chr7:50535776 DDC 0.43 6.14 0.32 2.44e-9 Malaria; CRC cis rs6570726 0.755 rs2092296 chr6:145893684 A/C cg05347473 chr6:146136440 FBXO30 0.38 5.85 0.31 1.18e-8 Lobe attachment (rater-scored or self-reported); CRC cis rs9287719 0.601 rs10178751 chr2:10734203 T/C cg00105475 chr2:10696890 NA 0.44 7.0 0.36 1.43e-11 Prostate cancer; CRC cis rs34172651 0.517 rs2287783 chr16:24831727 C/T cg00339695 chr16:24857497 SLC5A11 0.42 8.64 0.43 2.56e-16 Intelligence (multi-trait analysis); CRC cis rs798554 0.797 rs2107964 chr7:2863574 G/A cg04166393 chr7:2884313 GNA12 0.57 7.6 0.39 3.06e-13 Height; CRC cis rs4481887 0.861 rs10788776 chr1:248479177 T/C cg00666640 chr1:248458726 OR2T12 0.47 8.03 0.4 1.78e-14 Common traits (Other); CRC cis rs694739 0.628 rs475032 chr11:64140737 G/C cg23796481 chr11:64053134 BAD;GPR137 -0.47 -6.95 -0.36 1.97e-11 Alopecia areata;Crohn's disease;Psoriasis vulgaris; CRC cis rs4332037 0.615 rs62435134 chr7:1895463 T/G cg24505167 chr7:1915268 MAD1L1 -0.4 -5.66 -0.3 3.3e-8 Bipolar disorder; CRC cis rs847577 0.722 rs1013886 chr7:97709861 A/G cg00277769 chr7:97922759 BAIAP2L1 0.41 6.99 0.36 1.58e-11 Breast cancer; CRC cis rs863345 0.967 rs10908683 chr1:158522770 C/G cg12129480 chr1:158549410 OR10X1 -0.26 -5.68 -0.3 2.93e-8 Pneumococcal bacteremia; CRC cis rs782590 0.967 rs782592 chr2:55843875 T/A cg18811423 chr2:55921094 PNPT1 0.7 10.65 0.51 6.12e-23 Metabolic syndrome; CRC cis rs1799949 1.000 rs8176318 chr17:41197274 G/T cg05368731 chr17:41323189 NBR1 0.57 8.34 0.42 2.09e-15 Menopause (age at onset); CRC cis rs2836974 0.863 rs12483216 chr21:40539614 T/C cg17971929 chr21:40555470 PSMG1 0.81 11.93 0.55 1.61e-27 Cognitive function; CRC cis rs9914988 0.887 rs62066838 chr17:27184533 C/T cg12682573 chr17:27188876 MIR451;MIR144 -0.6 -8.81 -0.44 7.1e-17 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs9611565 0.694 rs202617 chr22:41822793 C/T cg06634786 chr22:41940651 POLR3H 0.69 7.85 0.4 5.88e-14 Vitiligo; CRC cis rs4294134 1.000 rs10234309 chr7:135311167 G/A cg20392616 chr7:135392013 SLC13A4 -0.5 -5.87 -0.31 1.08e-8 Paget's disease; CRC cis rs4713118 0.513 rs200971 chr6:27858904 C/T cg21251018 chr6:28226885 NKAPL 0.53 8.11 0.41 1.03e-14 Parkinson's disease; CRC cis rs1552244 0.882 rs17081288 chr3:10042113 A/G cg16606324 chr3:10149918 C3orf24 0.64 8.31 0.42 2.59e-15 Alzheimer's disease; CRC cis rs7917772 0.636 rs2249845 chr10:104512095 A/G cg11453585 chr10:104263688 ACTR1A;SUFU -0.69 -10.16 -0.49 2.95e-21 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC trans rs11039798 0.588 rs12278284 chr11:48612063 G/C cg03929089 chr4:120376271 NA 0.66 7.23 0.37 3.32e-12 Axial length; CRC cis rs1129187 0.755 rs28868299 chr6:42921221 T/G cg05552183 chr6:42928497 GNMT 0.52 7.84 0.4 6.21e-14 Alzheimer's disease in APOE e4+ carriers; CRC cis rs9660180 1.000 rs3737628 chr1:1722932 C/T cg17747265 chr1:1875780 NA -0.74 -13.0 -0.58 1.76e-31 Body mass index; CRC cis rs782590 0.967 rs11125581 chr2:55796527 C/G cg18811423 chr2:55921094 PNPT1 0.81 15.0 0.64 4.08e-39 Metabolic syndrome; CRC cis rs4970988 0.640 rs7524734 chr1:150655686 C/T cg10589385 chr1:150898437 SETDB1 0.28 5.98 0.31 5.86e-9 Urate levels; CRC cis rs2033908 0.619 rs10765994 chr11:12850819 A/G cg25843174 chr11:12811716 TEAD1 0.43 7.61 0.39 2.97e-13 Sitting height ratio; CRC cis rs9303401 0.614 rs12947982 chr17:57140301 A/G cg02118635 chr17:56770003 RAD51C;TEX14 0.69 8.62 0.43 2.88e-16 Cognitive test performance; CRC cis rs6952808 0.531 rs3779003 chr7:2184902 C/T cg21782813 chr7:2030301 MAD1L1 0.48 8.36 0.42 1.86e-15 Bipolar disorder and schizophrenia; CRC cis rs2019137 0.560 rs10206269 chr2:113990393 C/A cg01577475 chr2:114033581 PAX8;LOC440839 -0.26 -6.48 -0.34 3.4e-10 Lymphocyte counts; CRC cis rs9443645 0.869 rs4706080 chr6:79760997 C/T cg05283184 chr6:79620031 NA -0.61 -9.85 -0.48 3.19e-20 Intelligence (multi-trait analysis); CRC cis rs4927850 0.723 rs7630825 chr3:195753740 T/C cg00031303 chr3:195681400 NA 0.51 7.53 0.38 5.05e-13 Pancreatic cancer; CRC cis rs2243480 1.000 rs313798 chr7:65493031 A/G cg18252515 chr7:66147081 NA -1.14 -12.55 -0.57 8.91e-30 Diabetic kidney disease; CRC cis rs1018836 0.859 rs10808614 chr8:91569677 C/G cg16814680 chr8:91681699 NA -0.63 -9.81 -0.48 4.18e-20 Ejection fraction in Tripanosoma cruzi seropositivity; CRC cis rs4665809 1.000 rs2384322 chr2:26291146 C/G cg25036284 chr2:26402008 FAM59B -0.46 -5.78 -0.3 1.72e-8 Gut microbiome composition (summer); CRC cis rs1005277 0.579 rs2474599 chr10:38438939 A/G cg25517755 chr10:38738941 LOC399744 -0.42 -6.12 -0.32 2.69e-9 Extrinsic epigenetic age acceleration; CRC cis rs9649213 0.614 rs62479858 chr7:97924226 C/T cg09267113 chr7:98030324 BAIAP2L1 -0.95 -11.87 -0.55 2.67e-27 Prostate cancer (SNP x SNP interaction); CRC cis rs12681287 0.547 rs7459877 chr8:87505660 G/A cg27223183 chr8:87520930 FAM82B -0.52 -7.33 -0.37 1.81e-12 Caudate activity during reward; CRC cis rs67478160 0.643 rs12891175 chr14:104274166 T/C cg08213375 chr14:104286397 PPP1R13B 0.62 12.96 0.58 2.67e-31 Schizophrenia; CRC cis rs4713118 0.581 rs200504 chr6:27785820 T/C cg03623178 chr6:28175578 NA 0.58 6.37 0.33 6.5e-10 Parkinson's disease; CRC cis rs7615952 0.641 rs7632497 chr3:125783086 A/C cg06494592 chr3:125709126 NA -0.56 -6.74 -0.35 7.2e-11 Blood pressure (smoking interaction); CRC cis rs12143943 0.866 rs4252726 chr1:204513402 G/A cg17419461 chr1:204415978 PIK3C2B 0.4 6.18 0.32 1.87e-9 Cognitive performance; CRC cis rs216303 1.000 rs216302 chr12:6158022 G/A cg19878637 chr12:6148451 VWF -0.54 -6.0 -0.31 5.32e-9 Low vWF levels; CRC cis rs10197940 0.789 rs2444256 chr2:152280365 C/T cg19508488 chr2:152266495 RIF1 0.53 8.14 0.41 8.21e-15 Lung cancer; CRC cis rs11190604 0.666 rs7084768 chr10:102200497 T/C cg07080220 chr10:102295463 HIF1AN -0.49 -6.3 -0.33 9.34e-10 Palmitoleic acid (16:1n-7) levels; CRC cis rs9916302 0.904 rs13341996 chr17:37536862 C/T cg07936489 chr17:37558343 FBXL20 0.81 12.46 0.57 1.95e-29 Glomerular filtration rate (creatinine); CRC cis rs11622475 1.000 rs8021692 chr14:104428576 C/G cg12183467 chr14:104352244 NA -0.5 -6.96 -0.36 1.83e-11 Bipolar disorder; CRC cis rs4332037 0.664 rs73046334 chr7:1887037 T/C cg23422044 chr7:1970798 MAD1L1 -0.49 -6.34 -0.33 7.67e-10 Bipolar disorder; CRC cis rs2898681 0.614 rs962416 chr4:53695657 G/T cg00338735 chr4:53728038 RASL11B -0.44 -6.78 -0.35 5.45e-11 Optic nerve measurement (cup area); CRC cis rs9322193 0.923 rs10782316 chr6:150073891 A/C cg13206674 chr6:150067644 NUP43 0.68 10.28 0.49 1.08e-21 Lung cancer; CRC cis rs17092148 0.943 rs4911160 chr20:33349940 G/A cg08999081 chr20:33150536 PIGU 0.46 5.68 0.3 3.01e-8 Neuroticism; CRC cis rs7613875 0.620 rs3774734 chr3:50108792 C/A cg24110177 chr3:50126178 RBM5 0.54 8.02 0.4 1.9e-14 Body mass index; CRC cis rs6893300 0.524 rs62404348 chr5:179146026 G/A cg14593053 chr5:179126677 CANX 0.49 7.69 0.39 1.73e-13 Resting heart rate; CRC trans rs453301 0.571 rs2929305 chr8:9085217 G/A cg16141378 chr3:129829833 LOC729375 0.4 6.12 0.32 2.63e-9 Joint mobility (Beighton score); CRC cis rs10512697 0.655 rs34560950 chr5:3512343 G/A cg19473799 chr5:3511975 NA -0.83 -6.34 -0.33 7.66e-10 Immune response to smallpox vaccine (IL-6); CRC cis rs7524258 0.835 rs2412150 chr1:7303343 A/C cg07173049 chr1:7289937 CAMTA1 0.61 9.81 0.48 4.13e-20 Tourette's syndrome or obsessive-compulsive disorder; CRC cis rs10504229 0.679 rs11781858 chr8:58038406 C/T cg08219700 chr8:58056026 NA 0.53 6.09 0.32 3.21e-9 Developmental language disorder (linguistic errors); CRC cis rs9304742 0.888 rs8111514 chr19:53457246 G/A cg09915433 chr19:53449742 NA -0.6 -8.96 -0.44 2.5e-17 Psoriasis; CRC cis rs2243480 1.000 rs1553174 chr7:65731194 T/C cg18252515 chr7:66147081 NA 1.27 14.66 0.63 8.59e-38 Diabetic kidney disease; CRC cis rs5753618 0.561 rs2283879 chr22:31638448 G/A cg07713946 chr22:31675144 LIMK2 -0.39 -5.6 -0.3 4.42e-8 Colorectal cancer; CRC cis rs7940866 0.774 rs12420126 chr11:130834811 C/T cg12179176 chr11:130786555 SNX19 0.59 8.61 0.43 3.06e-16 Schizophrenia; CRC cis rs4713118 0.866 rs2179094 chr6:27741825 T/C cg19041857 chr6:27730383 NA -0.45 -6.13 -0.32 2.58e-9 Parkinson's disease; CRC trans rs7615952 0.546 rs2979306 chr3:125312130 C/A cg00769240 chr8:12517080 NA -0.61 -6.99 -0.36 1.55e-11 Blood pressure (smoking interaction); CRC cis rs2404602 0.692 rs1838048 chr15:76931679 A/G cg23625390 chr15:77176239 SCAPER 0.48 6.92 0.36 2.34e-11 Blood metabolite levels; CRC cis rs1401999 0.934 rs1132776 chr3:183696402 A/G cg01324343 chr3:183735012 ABCC5 0.75 13.52 0.6 1.98e-33 Anterior chamber depth; CRC trans rs9929218 0.731 rs72785179 chr16:68767912 C/T cg04657470 chr2:198365150 HSPE1;HSPD1 -0.96 -14.45 -0.62 5.67e-37 Colorectal cancer; CRC cis rs853679 0.546 rs13214023 chr6:28332141 A/G cg26958806 chr6:27640298 NA -0.84 -6.15 -0.32 2.3e-9 Depression; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg02258066 chr2:65357768 RAB1A 0.4 6.06 0.32 3.67e-9 Liver disease severity in Alagille syndrome; CRC cis rs1348850 0.567 rs4144276 chr2:178523420 T/C cg22681709 chr2:178499509 PDE11A -0.43 -7.97 -0.4 2.59e-14 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC trans rs1814175 0.765 rs1722003 chr11:49895896 G/A cg03929089 chr4:120376271 NA -0.98 -19.31 -0.73 4.27e-56 Height; CRC cis rs7399018 0.643 rs6580810 chr12:51610478 C/T cg25754956 chr12:51612065 POU6F1 0.83 11.36 0.53 1.87e-25 Cisplatin-induced ototoxicity; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg19969113 chr12:118810441 TAOK3 0.41 6.27 0.33 1.13e-9 Liver disease severity in Alagille syndrome; CRC cis rs769267 0.930 rs2304098 chr19:19646272 T/C cg01262667 chr19:19385393 TM6SF2 0.36 5.86 0.31 1.12e-8 Tonsillectomy; CRC cis rs854765 0.927 rs12943914 chr17:17980671 A/G cg24612305 chr17:17875800 TOM1L2;LRRC48 0.6 9.08 0.45 1.03e-17 Total body bone mineral density; CRC trans rs2303319 0.504 rs62189047 chr2:162613314 T/A cg18122310 chr12:50236657 BCDIN3D -0.73 -6.35 -0.33 7.23e-10 Cognitive function; CRC cis rs12291225 0.546 rs11023199 chr11:14394258 A/G cg19336497 chr11:14380999 RRAS2 -0.54 -9.47 -0.46 5.62e-19 Sense of smell; CRC cis rs875971 0.862 rs6958294 chr7:65794796 C/A cg12463550 chr7:65579703 CRCP -0.49 -6.59 -0.34 1.75e-10 Aortic root size; CRC cis rs7584330 0.518 rs7585975 chr2:238439089 G/A cg14458575 chr2:238380390 NA 0.74 9.33 0.46 1.63e-18 Prostate cancer; CRC cis rs1949733 1.000 rs2631740 chr4:8484106 C/A cg11789530 chr4:8429930 ACOX3 -0.83 -12.67 -0.57 3.01e-30 Response to antineoplastic agents; CRC cis rs17152411 0.895 rs61872118 chr10:126583450 C/T cg07906193 chr10:126599966 NA 0.54 6.0 0.31 5.1e-9 Height; CRC cis rs3026445 0.887 rs4766497 chr12:110950376 T/C cg12870014 chr12:110450643 ANKRD13A -0.39 -6.04 -0.32 4.18e-9 QT interval; CRC cis rs6429082 0.689 rs10802803 chr1:235709610 A/G cg26050004 chr1:235667680 B3GALNT2 -0.47 -5.78 -0.3 1.73e-8 Adiposity; CRC trans rs7395662 0.963 rs7119550 chr11:48927654 C/T cg21153622 chr11:89784906 NA -0.49 -7.78 -0.39 9.36e-14 HDL cholesterol; CRC cis rs9457247 0.663 rs2237277 chr6:167442107 G/A cg07741184 chr6:167504864 NA 0.35 6.32 0.33 8.58e-10 Crohn's disease; CRC cis rs7274811 0.681 rs210074 chr20:31949756 A/T cg07470512 chr20:32255052 NECAB3;C20orf134 0.42 5.74 0.3 2.15e-8 Height; CRC cis rs531930 0.959 rs506292 chr6:124735082 T/C cg05308643 chr6:124982296 NKAIN2 -0.43 -5.7 -0.3 2.62e-8 Celiac disease; CRC cis rs2565722 0.665 rs2465854 chr6:161310910 A/G cg03159191 chr6:161285451 NA 0.45 6.36 0.33 6.92e-10 Blood protein levels; CRC cis rs4509693 0.891 rs10748797 chr10:102502173 A/C cg23167259 chr10:102495509 NA -0.49 -6.76 -0.35 6.28e-11 Alzheimer's disease; CRC cis rs916888 0.610 rs142167 chr17:44795234 C/T cg01570182 chr17:44337453 NA -0.75 -9.22 -0.45 3.69e-18 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg23838375 chr17:72732946 RAB37 0.4 6.66 0.34 1.13e-10 Liver disease severity in Alagille syndrome; CRC cis rs6502050 0.842 rs8080305 chr17:80074516 A/C cg13198984 chr17:80129470 CCDC57 -0.48 -8.55 -0.43 4.76e-16 Life satisfaction; CRC cis rs780096 0.506 rs1728922 chr2:27644464 A/C cg21248554 chr2:27665150 KRTCAP3 -0.32 -7.39 -0.38 1.22e-12 Total body bone mineral density; CRC cis rs6460942 0.732 rs73677575 chr7:12286532 A/G cg06484146 chr7:12443880 VWDE -0.63 -6.52 -0.34 2.61e-10 Coronary artery disease; CRC cis rs7772486 0.875 rs2814873 chr6:146308932 T/C cg23711669 chr6:146136114 FBXO30 0.69 11.68 0.54 1.28e-26 Lobe attachment (rater-scored or self-reported); CRC cis rs875971 0.862 rs11760844 chr7:65739883 C/G cg11764359 chr7:65958608 NA -0.6 -9.24 -0.45 3.1e-18 Aortic root size; CRC cis rs898097 0.841 rs9896263 chr17:80902741 A/G cg15369054 chr17:80825471 TBCD -0.51 -8.37 -0.42 1.69e-15 Breast cancer; CRC cis rs832540 0.864 rs252908 chr5:56120686 T/C cg03609598 chr5:56110824 MAP3K1 -0.44 -6.23 -0.32 1.42e-9 Coronary artery disease; CRC cis rs4713118 0.513 rs149944 chr6:28002818 C/T cg23161317 chr6:28129485 ZNF389 0.44 6.47 0.34 3.48e-10 Parkinson's disease; CRC cis rs1348850 0.651 rs4893935 chr2:178240601 C/G cg02961200 chr2:178257176 LOC100130691;AGPS 0.47 6.69 0.35 9.84e-11 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC trans rs7615952 0.512 rs4679430 chr3:125357893 T/C cg02560186 chr11:3602584 NA -0.63 -9.54 -0.47 3.23e-19 Blood pressure (smoking interaction); CRC cis rs1729951 0.575 rs835641 chr3:136703474 G/T cg21827317 chr3:136751795 NA 0.36 5.87 0.31 1.05e-8 Neuroticism; CRC cis rs728616 0.867 rs1983776 chr10:81663695 C/T cg11900509 chr10:81946545 ANXA11 -0.62 -6.31 -0.33 8.96e-10 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs9926296 0.572 rs2376878 chr16:89885161 G/A cg03605463 chr16:89740564 NA -0.4 -6.04 -0.32 4.09e-9 Vitiligo; CRC cis rs4664293 0.647 rs7580816 chr2:160475881 G/A cg08347373 chr2:160653686 CD302 -0.39 -6.63 -0.34 1.4e-10 Monocyte percentage of white cells; CRC cis rs801193 0.569 rs13226966 chr7:66233623 A/G cg11764359 chr7:65958608 NA 0.58 8.77 0.44 1e-16 Aortic root size; CRC cis rs929354 0.772 rs10228145 chr7:157007337 A/G cg16102536 chr7:156981717 UBE3C 0.42 7.14 0.37 5.87e-12 Body mass index; CRC cis rs875971 0.545 rs73376394 chr7:65637681 C/T cg05627663 chr7:65219948 SNORA22;CCT6P1 0.55 7.3 0.37 2.22e-12 Aortic root size; CRC cis rs2645694 0.626 rs2703151 chr4:77834095 A/G cg06046430 chr4:77819534 ANKRD56 0.41 5.71 0.3 2.5e-8 Emphysema distribution in smoking; CRC cis rs425277 0.958 rs626479 chr1:2110260 A/G cg24578937 chr1:2090814 PRKCZ -0.67 -11.79 -0.55 5.29e-27 Height; CRC cis rs72627123 0.867 rs74395411 chr14:74478584 T/C cg12022184 chr14:74485813 ENTPD5;C14orf45 0.72 6.19 0.32 1.8e-9 Morning vs. evening chronotype; CRC cis rs7827545 1.000 rs9644456 chr8:135568656 G/T cg13086574 chr8:135490821 ZFAT -0.36 -6.27 -0.33 1.16e-9 Hypertension (SNP x SNP interaction); CRC cis rs7119 1.000 rs7119 chr15:77777632 C/T cg05673287 chr15:77411982 SGK269 -0.37 -6.22 -0.32 1.48e-9 Type 2 diabetes; CRC cis rs7811142 1.000 rs113738841 chr7:100081306 C/T cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.6 7.7 0.39 1.62e-13 Platelet count; CRC cis rs4891159 0.790 rs11150953 chr18:74145491 G/A cg24786174 chr18:74118243 ZNF516 -0.86 -14.6 -0.63 1.44e-37 Longevity; CRC cis rs734999 0.505 rs10910107 chr1:2539181 C/T cg20673091 chr1:2541236 MMEL1 0.36 5.9 0.31 8.92e-9 Ulcerative colitis; CRC cis rs2204008 0.748 rs11180579 chr12:38237830 A/G cg26384229 chr12:38710491 ALG10B 0.7 9.31 0.46 1.88e-18 Bladder cancer; CRC cis rs10512697 0.772 rs34227872 chr5:3523512 G/T cg19473799 chr5:3511975 NA -0.83 -6.35 -0.33 7e-10 Immune response to smallpox vaccine (IL-6); CRC cis rs2115536 0.730 rs4573897 chr15:80187225 G/A cg00225070 chr15:80189496 MTHFS 0.41 6.22 0.32 1.54e-9 Eosinophil counts;Eosinophil percentage of white cells;Sum eosinophil basophil counts;Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; CRC cis rs7618915 0.501 rs9917834 chr3:52634619 A/C cg18099408 chr3:52552593 STAB1 -0.48 -8.1 -0.41 1.06e-14 Bipolar disorder; CRC trans rs7618501 0.966 rs13063621 chr3:49821625 T/C cg21659725 chr3:3221576 CRBN 0.9 17.3 0.69 3.92e-48 Intelligence (multi-trait analysis); CRC cis rs6964587 1.000 rs12540055 chr7:91707921 A/G cg17063962 chr7:91808500 NA 0.74 12.94 0.58 2.97e-31 Breast cancer; CRC cis rs1008375 0.932 rs6844593 chr4:17659039 T/C cg16339924 chr4:17578868 LAP3 0.52 6.58 0.34 1.9e-10 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs4253772 0.591 rs6007726 chr22:46650858 A/C cg03482458 chr22:46692211 CN5H6.4;GTSE1 0.46 6.09 0.32 3.1e-9 LDL cholesterol;Cholesterol, total; CRC cis rs11098499 0.775 rs10029303 chr4:120286755 T/A cg09307838 chr4:120376055 NA 0.68 10.53 0.5 1.51e-22 Corneal astigmatism; CRC cis rs11971779 0.715 rs7779390 chr7:139112953 C/T cg07862535 chr7:139043722 LUC7L2 0.57 7.35 0.38 1.61e-12 Diisocyanate-induced asthma; CRC cis rs6499255 0.951 rs16958970 chr16:69627793 G/A cg04110750 chr16:69646130 NFAT5 -0.57 -7.72 -0.39 1.45e-13 IgE levels; CRC cis rs9491140 0.514 rs11154227 chr6:124681816 G/A cg19267163 chr6:125004984 NKAIN2 0.46 5.97 0.31 6.31e-9 Neuroticism; CRC cis rs3736485 0.966 rs11634039 chr15:51895575 C/T cg08986416 chr15:51914746 DMXL2 -0.47 -6.7 -0.35 9e-11 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC trans rs2303319 0.504 rs62189048 chr2:162613494 G/C cg13490827 chr1:46269305 MAST2 -0.69 -6.0 -0.31 5.24e-9 Cognitive function; CRC cis rs769267 0.930 rs2315022 chr19:19413381 A/G cg20644253 chr19:19431407 KIAA0892;SF4 0.42 5.77 0.3 1.85e-8 Tonsillectomy; CRC cis rs6933660 0.683 rs6916340 chr6:151779064 T/C cg14416726 chr6:151773293 C6orf211;RMND1 -0.77 -12.83 -0.58 8.13e-31 Menarche (age at onset); CRC cis rs4713118 0.523 rs2179096 chr6:27665920 C/T cg15845792 chr6:28175446 NA 0.6 8.68 0.43 1.8e-16 Parkinson's disease; CRC cis rs11098499 0.954 rs10518331 chr4:120323595 C/T cg09307838 chr4:120376055 NA 0.72 11.14 0.52 1.1e-24 Corneal astigmatism; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg14451452 chr21:33104301 SFRS15 0.46 6.25 0.33 1.29e-9 Anxiety disorder; CRC cis rs56399783 0.901 rs73049380 chr7:2832845 C/T cg19731401 chr7:2775893 GNA12 0.58 6.16 0.32 2.11e-9 Childhood ear infection; CRC cis rs2880765 0.835 rs4280192 chr15:86043020 G/A cg17133734 chr15:86042851 AKAP13 0.42 6.76 0.35 6.22e-11 Coronary artery disease; CRC cis rs4713118 0.868 rs35069907 chr6:27746692 T/C cg20933634 chr6:27740509 NA 0.59 6.91 0.36 2.55e-11 Parkinson's disease; CRC cis rs6912958 0.631 rs9450704 chr6:88182704 G/C cg08069147 chr6:88032118 GJB7;C6orf162 -0.56 -8.33 -0.42 2.29e-15 Monocyte percentage of white cells; CRC cis rs853679 0.713 rs200991 chr6:27815494 A/C cg15845792 chr6:28175446 NA -0.58 -6.29 -0.33 9.99e-10 Depression; CRC cis rs875971 1.000 rs6958277 chr7:65979349 A/G cg12463550 chr7:65579703 CRCP 0.47 6.76 0.35 6.2e-11 Aortic root size; CRC cis rs6912958 1.000 rs6937823 chr6:88160386 G/C cg12350822 chr6:88032061 C6orf162;GJB7 -0.41 -7.85 -0.4 5.73e-14 Monocyte percentage of white cells; CRC cis rs6860806 0.631 rs7736284 chr5:131588151 T/C cg02033258 chr5:131593261 PDLIM4 0.41 7.89 0.4 4.37e-14 Breast cancer; CRC cis rs9814567 1.000 rs9819532 chr3:134288644 G/C cg06541857 chr3:134203789 ANAPC13;CEP63 -0.4 -5.98 -0.31 5.95e-9 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs9322193 0.923 rs1112729 chr6:150087627 C/A cg05861140 chr6:150128134 PCMT1 -0.44 -7.18 -0.37 4.53e-12 Lung cancer; CRC cis rs12142240 0.660 rs72886903 chr1:46813860 C/T cg00530320 chr1:46809349 NSUN4 0.58 7.81 0.4 7.54e-14 Menopause (age at onset); CRC trans rs12310956 0.532 rs10506119 chr12:33963684 A/G cg26384229 chr12:38710491 ALG10B 0.52 6.57 0.34 1.99e-10 Morning vs. evening chronotype; CRC cis rs4713118 0.621 rs10484403 chr6:28033523 A/G cg15786705 chr6:28176104 NA 0.73 9.43 0.46 7.63e-19 Parkinson's disease; CRC cis rs7119 0.651 rs12904208 chr15:77845911 C/T cg10437265 chr15:77819839 NA 0.59 9.99 0.48 1.03e-20 Type 2 diabetes; CRC cis rs853679 0.517 rs9380056 chr6:28104476 C/T cg12172441 chr6:28176163 NA 0.62 7.4 0.38 1.17e-12 Depression; CRC cis rs1448094 0.512 rs4362214 chr12:86245145 C/T cg00310523 chr12:86230176 RASSF9 0.33 5.62 0.3 3.97e-8 Major depressive disorder; CRC cis rs3768617 0.811 rs12738377 chr1:183031256 C/T ch.1.3577855R chr1:183094577 LAMC1 0.62 9.12 0.45 7.61e-18 Fuchs's corneal dystrophy; CRC cis rs317689 0.690 rs317656 chr12:69681101 T/A cg20891283 chr12:69753455 YEATS4 0.45 5.97 0.31 6.11e-9 Response to diuretic therapy; CRC cis rs4975709 0.569 rs1684965 chr5:1865248 A/G cg06654549 chr5:1875058 NA 0.43 6.32 0.33 8.74e-10 Cardiovascular disease risk factors; CRC cis rs4065321 0.522 rs3744245 chr17:38146542 C/G cg17467752 chr17:38218738 THRA -0.5 -7.23 -0.37 3.39e-12 White blood cell count (basophil);White blood cell count; CRC cis rs2062225 1.000 rs6731964 chr2:111762043 T/C cg11729679 chr2:111877065 BCL2L11 -0.56 -5.62 -0.3 4.08e-8 Monocyte count; CRC trans rs656319 0.638 rs670044 chr8:9892529 G/T cg06636001 chr8:8085503 FLJ10661 0.47 6.73 0.35 7.59e-11 Myopia (pathological); CRC cis rs7274811 0.681 rs293733 chr20:31975976 C/T cg03904042 chr20:32255491 NECAB3;C20orf134 0.41 5.78 0.3 1.75e-8 Height; CRC cis rs4654899 0.758 rs3820326 chr1:21277141 G/A cg02927042 chr1:21476669 EIF4G3 -0.39 -6.18 -0.32 1.93e-9 Superior frontal gyrus grey matter volume; CRC cis rs826838 1.000 rs826851 chr12:39112639 A/G cg13010199 chr12:38710504 ALG10B -0.41 -5.93 -0.31 7.47e-9 Heart rate; CRC cis rs1448094 0.872 rs7311150 chr12:86435989 A/T cg02569458 chr12:86230093 RASSF9 0.39 6.51 0.34 2.8e-10 Major depressive disorder; CRC cis rs8177253 0.665 rs9869535 chr3:133451581 G/A cg11941060 chr3:133502564 NA -0.47 -7.65 -0.39 2.28e-13 Iron status biomarkers; CRC cis rs6951245 1.000 rs113575110 chr7:1084394 G/A cg03188948 chr7:1209495 NA 0.64 6.59 0.34 1.72e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs6540559 1.000 rs17015259 chr1:209982923 G/A cg22029157 chr1:209979665 IRF6 0.63 9.58 0.47 2.53e-19 Cleft lip with or without cleft palate; CRC cis rs1005277 0.505 rs10827836 chr10:38215441 A/G cg00409905 chr10:38381863 ZNF37A 0.63 10.21 0.49 1.91e-21 Extrinsic epigenetic age acceleration; CRC cis rs10791323 0.569 rs10750553 chr11:133740251 T/C cg15485101 chr11:133734466 NA 0.43 8.1 0.41 1.06e-14 Childhood ear infection; CRC cis rs4073582 1.000 rs524859 chr11:66041079 G/A cg16950941 chr11:66035639 RAB1B 0.7 10.39 0.5 4.59e-22 Gout; CRC cis rs8105895 0.935 rs62110993 chr19:22268260 G/A cg02657401 chr19:22469223 NA -0.37 -5.73 -0.3 2.32e-8 Body mass index (change over time); CRC trans rs262150 0.819 rs6956589 chr7:158769301 C/T cg21167628 chr1:45308625 PTCH2 -0.38 -6.46 -0.34 3.86e-10 Facial morphology (factor 20); CRC cis rs372883 0.613 rs1153274 chr21:30660026 T/C cg08807101 chr21:30365312 RNF160 -0.56 -7.76 -0.39 1.07e-13 Pancreatic cancer; CRC cis rs2153535 0.505 rs9405395 chr6:8468622 T/A cg21535247 chr6:8435926 SLC35B3 0.5 7.56 0.38 3.95e-13 Motion sickness; CRC cis rs10540 1.000 rs61876332 chr11:487101 C/T cg19913688 chr11:428466 ANO9 -0.73 -7.41 -0.38 1.08e-12 Body mass index; CRC cis rs58141407 1 rs58141407 chr8:21791772 C/T cg25597362 chr8:21767310 DOK2 -0.58 -6.48 -0.34 3.32e-10 Red blood cell count;Mean corpuscular volume; CRC cis rs9372498 0.536 rs17424234 chr6:118808521 A/G cg24463073 chr6:118973353 C6orf204 0.54 7.01 0.36 1.36e-11 Diastolic blood pressure; CRC trans rs1814175 0.817 rs10128730 chr11:50023369 G/T cg03929089 chr4:120376271 NA -0.95 -19.14 -0.73 2.04e-55 Height; CRC cis rs25645 0.502 rs7223318 chr17:38108553 G/C cg24910161 chr17:38119198 GSDMA -0.36 -5.95 -0.31 6.8e-9 Myeloid white cell count; CRC cis rs5769765 0.646 rs9627789 chr22:50300562 A/G cg02269571 chr22:50332266 NA -0.59 -7.98 -0.4 2.47e-14 Schizophrenia; CRC cis rs4555082 0.957 rs2816628 chr14:105736134 T/G cg13114125 chr14:105738426 BRF1 -0.71 -11.0 -0.52 3.53e-24 Mean platelet volume;Platelet distribution width; CRC cis rs12621445 1 rs12621445 chr2:24154964 C/T cg08917208 chr2:24149416 ATAD2B 1.03 10.1 0.49 4.66e-21 Immature fraction of reticulocytes; CRC cis rs9858542 0.953 rs67216675 chr3:49493151 G/T cg03060546 chr3:49711283 APEH -0.46 -6.49 -0.34 3.17e-10 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs4665809 0.878 rs4665826 chr2:26367503 A/T cg04944784 chr2:26401820 FAM59B 0.72 8.71 0.43 1.53e-16 Gut microbiome composition (summer); CRC cis rs7615952 0.932 rs11922218 chr3:125631289 C/T cg05084668 chr3:125655381 ALG1L -0.57 -8.12 -0.41 9.14e-15 Blood pressure (smoking interaction); CRC cis rs17666538 0.792 rs7820788 chr8:601846 C/T cg23958373 chr8:599963 NA 0.94 8.96 0.44 2.43e-17 IgG glycosylation; CRC cis rs28386778 0.863 rs2597633 chr17:61872871 T/C cg07362569 chr17:61921086 SMARCD2 0.39 5.99 0.31 5.59e-9 Prudent dietary pattern; CRC cis rs28386778 0.830 rs67905415 chr17:61841236 G/A cg11494091 chr17:61959527 GH2 0.6 10.2 0.49 2.13e-21 Prudent dietary pattern; CRC cis rs11212617 1.000 rs227094 chr11:108233800 C/A cg14761454 chr11:108092087 ATM;NPAT 0.45 6.72 0.35 8.02e-11 Response to metformin in type 2 diabetes (glycemic); CRC cis rs4481887 0.830 rs6686474 chr1:248477116 A/C cg00666640 chr1:248458726 OR2T12 0.49 8.27 0.41 3.45e-15 Common traits (Other); CRC cis rs4664293 0.833 rs10170336 chr2:160589343 T/C cg08347373 chr2:160653686 CD302 -0.35 -5.61 -0.3 4.36e-8 Monocyte percentage of white cells; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg17308151 chr11:8703888 RPL27A 0.47 6.75 0.35 6.68e-11 Response to antipsychotic treatment; CRC cis rs4664293 0.967 rs12611922 chr2:160462749 T/G cg08347373 chr2:160653686 CD302 -0.45 -7.31 -0.37 2.02e-12 Monocyte percentage of white cells; CRC trans rs6940638 0.956 rs36048693 chr6:27032711 T/G cg15845792 chr6:28175446 NA 0.65 7.33 0.37 1.85e-12 Intelligence (multi-trait analysis); CRC cis rs73206853 0.563 rs4073472 chr12:111176494 A/G cg12870014 chr12:110450643 ANKRD13A 0.78 8.38 0.42 1.51e-15 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC cis rs2153535 0.580 rs1932282 chr6:8477330 G/A cg21535247 chr6:8435926 SLC35B3 0.5 7.53 0.38 4.89e-13 Motion sickness; CRC cis rs10911232 0.507 rs12037623 chr1:183000148 G/A ch.1.3577855R chr1:183094577 LAMC1 0.86 15.15 0.64 1.1e-39 Hypertriglyceridemia; CRC cis rs3749237 0.595 rs1464568 chr3:49458266 G/A cg02487422 chr3:49467188 NICN1 0.44 7.08 0.36 8.6e-12 Resting heart rate; CRC cis rs9303280 0.806 rs12941333 chr17:38040534 C/T cg11212589 chr17:38028394 ZPBP2 0.43 7.95 0.4 2.96e-14 Self-reported allergy; CRC cis rs9517320 1.000 rs9517320 chr13:99126303 G/T cg07423050 chr13:99094983 FARP1 -0.42 -6.77 -0.35 5.77e-11 Longevity; CRC cis rs1799949 1.000 rs11653069 chr17:41283377 C/T cg19454999 chr17:41278357 BRCA1;NBR2 0.55 8.63 0.43 2.68e-16 Menopause (age at onset); CRC cis rs1707322 1.000 rs4660336 chr1:46487976 T/C cg03146154 chr1:46216737 IPP -0.49 -6.94 -0.36 2.09e-11 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs11585357 0.895 rs877552 chr1:17631236 C/T cg08277548 chr1:17600880 PADI3 -0.83 -11.07 -0.52 2.05e-24 Hair shape; CRC cis rs9916302 0.808 rs12948906 chr17:37644854 C/T cg03013999 chr17:37608204 MED1 0.45 6.82 0.35 4.26e-11 Glomerular filtration rate (creatinine); CRC trans rs629535 0.814 rs558511 chr8:70069908 C/A cg21567404 chr3:27674614 NA 0.93 15.32 0.65 2.37e-40 Dupuytren's disease; CRC trans rs12599106 0.770 rs12445057 chr16:34970274 C/G cg20062050 chr1:227730881 NA 0.36 6.01 0.31 4.79e-9 Menopause (age at onset); CRC cis rs2233152 0.572 rs10403040 chr19:41296046 A/T cg21869046 chr19:41225005 ITPKC -0.34 -5.63 -0.3 3.94e-8 Kawasaki disease; CRC cis rs8062405 1.000 rs4451951 chr16:28836205 T/C cg08761264 chr16:28874980 SH2B1 -0.42 -5.69 -0.3 2.81e-8 Cognitive ability (multi-trait analysis);Cognitive ability; CRC cis rs7223966 1.000 rs12325866 chr17:61755974 G/A cg05941027 chr17:61774174 LIMD2 0.37 6.71 0.35 8.59e-11 Hip circumference adjusted for BMI;Body mass index; CRC cis rs6496667 0.779 rs16944509 chr15:91032003 G/A cg04176472 chr15:90893244 GABARAPL3 0.63 8.25 0.41 3.84e-15 Rheumatoid arthritis; CRC trans rs10269006 0.634 rs6465431 chr7:94374906 T/C cg05903386 chr2:217555456 IGFBP5 -0.38 -6.34 -0.33 7.38e-10 Breast cancer; CRC cis rs2386661 0.516 rs61832676 chr10:5646337 G/A cg02449762 chr10:5661741 NA -0.33 -5.68 -0.3 2.96e-8 Breast cancer; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg25789201 chr7:72395803 POM121 0.44 6.18 0.32 1.87e-9 Response to antipsychotic treatment; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G ch.2.148072779R chr2:148356309 NA 0.43 6.28 0.33 1.04e-9 Liver disease severity in Alagille syndrome; CRC cis rs11098499 0.954 rs4577559 chr4:120404043 T/G cg09307838 chr4:120376055 NA 0.7 10.94 0.52 5.84e-24 Corneal astigmatism; CRC cis rs2455601 0.507 rs7948452 chr11:8877704 T/C cg21881798 chr11:8931708 C11orf17;ST5 -0.46 -5.92 -0.31 8.27e-9 Schizophrenia; CRC cis rs3996993 0.809 rs4715332 chr6:52669185 C/A cg20803780 chr6:52668592 GSTA1 -0.38 -7.11 -0.36 7.41e-12 Hemoglobin concentration; CRC cis rs10857712 0.950 rs10857711 chr10:135224059 G/A cg01444801 chr10:135216882 MTG1 -0.57 -8.07 -0.41 1.33e-14 Systemic lupus erythematosus; CRC cis rs875971 0.929 rs12535036 chr7:65964063 G/T cg18876405 chr7:65276391 NA 0.51 8.78 0.44 9.39e-17 Aortic root size; CRC cis rs2302190 0.769 rs7215531 chr17:56493374 A/T cg12560992 chr17:57184187 TRIM37 0.49 5.8 0.3 1.54e-8 Vitamin D levels; CRC cis rs9443645 0.507 rs1475046 chr6:79461801 G/A cg09184832 chr6:79620586 NA -0.33 -6.37 -0.33 6.29e-10 Intelligence (multi-trait analysis); CRC cis rs8060686 0.516 rs255052 chr16:68024995 C/T cg26727032 chr16:67993705 SLC12A4 -0.55 -6.45 -0.34 3.98e-10 HDL cholesterol;Metabolic syndrome; CRC cis rs2836974 0.931 rs2735306 chr21:40713134 A/G cg17971929 chr21:40555470 PSMG1 -0.75 -10.44 -0.5 3.03e-22 Cognitive function; CRC cis rs4713118 0.513 rs1225591 chr6:28148752 G/A cg15786705 chr6:28176104 NA 0.64 9.21 0.45 3.94e-18 Parkinson's disease; CRC trans rs2303319 0.504 rs62189051 chr2:162622318 G/A cg10272801 chr16:14013773 ERCC4 -0.68 -6.07 -0.32 3.49e-9 Cognitive function; CRC cis rs9733 0.596 rs12085275 chr1:150650265 T/C cg17724175 chr1:150552817 MCL1 0.58 9.4 0.46 9.25e-19 Tonsillectomy; CRC cis rs2050392 0.517 rs7096279 chr10:30759608 C/T cg25182066 chr10:30743637 MAP3K8 -0.61 -8.65 -0.43 2.34e-16 Inflammatory bowel disease; CRC cis rs1799949 1.000 rs4793197 chr17:41231902 C/T cg05368731 chr17:41323189 NBR1 0.68 10.0 0.48 9.99e-21 Menopause (age at onset); CRC cis rs7666738 0.830 rs35939134 chr4:98980311 A/G cg17366294 chr4:99064904 C4orf37 0.43 7.33 0.37 1.76e-12 Colonoscopy-negative controls vs population controls; CRC cis rs9868809 0.772 rs12107252 chr3:48691316 T/C cg07636037 chr3:49044803 WDR6 -0.66 -7.08 -0.36 8.65e-12 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; CRC cis rs72781680 0.611 rs7596060 chr2:24334361 A/G cg20701182 chr2:24300061 SF3B14 -0.59 -7.02 -0.36 1.25e-11 Lymphocyte counts; CRC cis rs6840360 0.533 rs13139327 chr4:152728590 A/C cg09659197 chr4:152720779 NA 0.42 8.57 0.43 4.15e-16 Intelligence (multi-trait analysis); CRC cis rs708547 0.874 rs1630798 chr4:57883558 T/C cg25525207 chr4:57843836 C4orf14;POLR2B -0.46 -5.74 -0.3 2.13e-8 Response to bleomycin (chromatid breaks); CRC cis rs17209837 0.607 rs2071645 chr7:87105276 G/C cg00919237 chr7:87102261 ABCB4 -0.5 -6.53 -0.34 2.57e-10 Gallbladder cancer; CRC cis rs1964356 0.967 rs17701675 chr8:8850633 A/G cg06636001 chr8:8085503 FLJ10661 -0.52 -7.83 -0.4 6.67e-14 Mean corpuscular volume; CRC cis rs7811142 1.000 rs67471932 chr7:100009985 C/G cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.15 17.19 0.69 1.08e-47 Platelet count; CRC cis rs10540 1.000 rs35874808 chr11:506442 G/T cg03934478 chr11:495069 RNH1 0.7 7.81 0.4 7.99e-14 Body mass index; CRC cis rs2976388 0.647 rs2572906 chr8:143798269 G/A cg15511327 chr8:143859410 LYNX1 0.4 7.3 0.37 2.13e-12 Urinary tract infection frequency; CRC cis rs780096 0.525 rs13388159 chr2:27648284 A/T cg12000995 chr2:27665139 KRTCAP3 -0.3 -6.19 -0.32 1.77e-9 Total body bone mineral density; CRC cis rs4689388 0.926 rs10010131 chr4:6292915 A/G cg00701064 chr4:6280414 WFS1 0.74 12.91 0.58 4.03e-31 Type 2 diabetes and other traits;Type 2 diabetes; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg27078813 chr10:43633258 CSGALNACT2 0.46 6.57 0.34 2.01e-10 Response to antipsychotic treatment; CRC cis rs3814231 0.531 rs17090904 chr10:115476138 C/T cg24846397 chr10:115438155 CASP7 -0.34 -5.67 -0.3 3.17e-8 Vitiligo; CRC trans rs2727020 0.729 rs1164666 chr11:49295867 C/T cg03929089 chr4:120376271 NA -0.85 -14.71 -0.63 5.4e-38 Coronary artery disease; CRC cis rs812925 0.519 rs2463099 chr2:61618311 T/C cg10580144 chr2:61372316 C2orf74 -0.32 -6.99 -0.36 1.57e-11 Immature fraction of reticulocytes; CRC trans rs6011368 0.630 rs1570520 chr20:62910954 A/G cg13869341 chr1:15865 WASH5P 0.41 6.3 0.33 9.65e-10 Clozapine-induced cytotoxicity; CRC cis rs769267 1.000 rs2074090 chr19:19449686 G/T cg02546618 chr19:19431379 KIAA0892;SF4 -0.46 -6.45 -0.34 3.92e-10 Tonsillectomy; CRC trans rs10099002 0.643 rs12679657 chr8:5157061 A/G cg04650094 chr6:41006974 UNC5CL 0.36 6.06 0.32 3.81e-9 Epstein-Barr virus copy number in lymphoblastoid cell lines; CRC cis rs881375 0.967 rs2109895 chr9:123677827 C/T cg14255062 chr9:123606675 PSMD5;LOC253039 0.42 6.11 0.32 2.86e-9 Rheumatoid arthritis; CRC trans rs12478296 0.901 rs7420176 chr2:243005277 G/A cg06834434 chr14:75079333 LTBP2 0.56 7.1 0.36 7.83e-12 Obesity-related traits; CRC cis rs7927771 0.864 rs755554 chr11:47432034 G/C cg18512352 chr11:47633146 NA 0.35 6.8 0.35 4.95e-11 Subjective well-being; CRC cis rs798554 0.959 rs798557 chr7:2758982 G/A cg19346786 chr7:2764209 NA -0.41 -7.19 -0.37 4.29e-12 Height; CRC cis rs6570726 0.935 rs400968 chr6:145819718 A/G cg23711669 chr6:146136114 FBXO30 0.69 11.94 0.55 1.55e-27 Lobe attachment (rater-scored or self-reported); CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg03160445 chr3:100120349 LNP1;TOMM70A 0.53 6.82 0.35 4.36e-11 Thyroid stimulating hormone; CRC cis rs7085104 0.591 rs4919683 chr10:104585125 G/T cg15744005 chr10:104629667 AS3MT -0.35 -7.19 -0.37 4.37e-12 Immature fraction of reticulocytes;Schizophrenia; CRC cis rs75804782 0.641 rs72987328 chr2:239360097 C/T cg18131467 chr2:239335373 ASB1 -0.68 -5.89 -0.31 9.58e-9 Morning vs. evening chronotype;Chronotype; CRC cis rs6908034 0.607 rs75060331 chr6:19812956 C/T cg02682789 chr6:19804855 NA 0.81 6.48 0.34 3.35e-10 Endometriosis;Deep ovarian and/or rectovaginal disease with dense adhesions; CRC cis rs4604732 0.631 rs74154672 chr1:247625625 C/G cg02104434 chr1:247694406 LOC148824;OR2C3 0.6 8.82 0.44 6.67e-17 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CRC cis rs2213920 0.749 rs10121366 chr9:118244022 T/C cg13918206 chr9:118159781 DEC1 0.56 5.7 0.3 2.67e-8 Docetaxel-induced peripheral neuropathy in metastatic castrate-resistant prostate cancer; CRC cis rs7692995 1.000 rs6811842 chr4:18009798 T/A cg08925142 chr4:18023851 LCORL -0.53 -5.89 -0.31 9.52e-9 Height; CRC cis rs6903823 0.508 rs1233660 chr6:28260249 T/A cg03623178 chr6:28175578 NA 0.41 5.63 0.3 3.91e-8 Pulmonary function; CRC cis rs9354308 0.899 rs2802058 chr6:66550787 T/G cg07460842 chr6:66804631 NA 0.46 5.69 0.3 2.79e-8 Metabolite levels; CRC trans rs2303319 0.504 rs62187655 chr2:162487440 C/G cg16721101 chr20:25176146 ENTPD6 -0.7 -6.08 -0.32 3.35e-9 Cognitive function; CRC cis rs4423214 1.000 rs12797951 chr11:71143266 G/T cg05163923 chr11:71159392 DHCR7 -0.66 -9.54 -0.47 3.28e-19 Vitamin D levels; CRC cis rs2635047 0.638 rs2635054 chr18:44653028 C/T cg19077165 chr18:44547161 KATNAL2 0.42 6.32 0.33 8.61e-10 Educational attainment; CRC cis rs6540556 0.954 rs6685077 chr1:209933331 A/G cg23920097 chr1:209922102 NA -0.52 -6.59 -0.34 1.72e-10 Red blood cell count; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg03738979 chr19:11145704 SMARCA4 -0.39 -6.12 -0.32 2.67e-9 Intelligence (multi-trait analysis); CRC cis rs6951245 0.786 rs77943789 chr7:1140158 C/T cg03188948 chr7:1209495 NA 0.61 6.64 0.34 1.28e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs929354 1.000 rs1182384 chr7:157040642 A/G cg17757837 chr7:157058334 UBE3C -0.81 -14.77 -0.63 3.3e-38 Body mass index; CRC cis rs60871478 0.541 rs56964970 chr7:910791 G/C cg13844804 chr7:814759 HEATR2 -0.53 -5.61 -0.3 4.37e-8 Cerebrospinal P-tau181p levels; CRC cis rs4604732 0.631 rs12080860 chr1:247623053 A/G cg12754571 chr1:247694271 LOC148824;OR2C3 0.43 5.83 0.31 1.29e-8 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CRC cis rs7224685 0.501 rs4790169 chr17:4022665 G/A cg09597638 chr17:3907349 NA -0.66 -11.6 -0.54 2.65e-26 Type 2 diabetes; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg08052428 chr9:135996421 RALGDS 0.49 7.05 0.36 1.06e-11 Response to antipsychotic treatment; CRC cis rs2011503 0.882 rs56144632 chr19:19368310 G/A cg11584989 chr19:19387371 SF4 0.6 6.77 0.35 5.87e-11 Bipolar disorder; CRC cis rs3126085 0.877 rs3126055 chr1:152266364 G/A cg09127314 chr1:152161683 NA -0.45 -5.75 -0.3 2.05e-8 Atopic dermatitis; CRC trans rs1642645 0.831 rs7529102 chr1:42493322 T/C cg16926213 chr1:1841314 NA -0.43 -6.17 -0.32 1.96e-9 Left ventricular obstructive tract defect (maternal effect); CRC cis rs9818758 0.607 rs9837625 chr3:49215966 C/T cg00383909 chr3:49044727 WDR6 1.07 10.44 0.5 3.1e-22 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; CRC cis rs10504229 0.679 rs10504217 chr8:58037522 A/G cg22535103 chr8:58192502 C8orf71 -0.44 -5.8 -0.3 1.55e-8 Developmental language disorder (linguistic errors); CRC cis rs12519773 0.517 rs17360811 chr5:92492349 G/A cg18783429 chr5:92414398 NA 0.27 5.78 0.3 1.78e-8 Migraine; CRC cis rs12142240 0.698 rs56063031 chr1:46825433 C/T cg00530320 chr1:46809349 NSUN4 0.59 8.03 0.41 1.69e-14 Menopause (age at onset); CRC trans rs12940923 1.000 rs11079343 chr17:56369007 T/C cg16900910 chr15:72789182 ARIH1 0.52 5.97 0.31 6.15e-9 Circulating myeloperoxidase levels (plasma); CRC cis rs11030122 0.632 rs714380 chr11:4059653 A/T cg18678763 chr11:4115507 RRM1 -0.52 -8.57 -0.43 3.95e-16 Mean platelet volume;Platelet distribution width; CRC cis rs1799949 0.965 rs35521261 chr17:41313612 A/G cg19454999 chr17:41278357 BRCA1;NBR2 0.55 8.68 0.43 1.89e-16 Menopause (age at onset); CRC cis rs1552244 1.000 rs12152515 chr3:10143976 C/T cg00166722 chr3:10149974 C3orf24 0.62 8.7 0.43 1.66e-16 Alzheimer's disease; CRC cis rs7618915 0.547 rs7642198 chr3:52677960 T/C cg15147215 chr3:52552868 STAB1 -0.62 -10.24 -0.49 1.48e-21 Bipolar disorder; CRC cis rs11123170 0.543 rs12472361 chr2:113980645 C/G cg21550016 chr2:113992930 PAX8;LOC440839;LOC654433 0.52 6.08 0.32 3.35e-9 Renal function-related traits (BUN); CRC cis rs7927771 0.698 rs34467936 chr11:47915299 A/G cg20307385 chr11:47447363 PSMC3 -0.49 -6.52 -0.34 2.64e-10 Subjective well-being; CRC cis rs6951245 0.580 rs77101766 chr7:1122438 A/G cg21664854 chr7:1097933 C7orf50;GPR146 0.6 7.39 0.38 1.26e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC trans rs59964204 1.000 rs59964204 chr7:36939322 G/A cg10440835 chr17:78484142 NA 0.52 6.03 0.32 4.49e-9 Plasma androstenedione levels in resected early stage-receptor positive breast cancer; CRC cis rs2760061 0.819 rs708111 chr1:228191365 G/A cg18477163 chr1:228402036 OBSCN 0.42 7.01 0.36 1.32e-11 Diastolic blood pressure; CRC cis rs67311347 0.956 rs6771527 chr3:40506548 T/C cg24209194 chr3:40518798 ZNF619 -0.42 -6.08 -0.32 3.29e-9 Renal cell carcinoma; CRC cis rs2842992 0.789 rs4276525 chr6:160193612 G/A cg11366901 chr6:160182831 ACAT2 0.96 14.11 0.61 1.11e-35 Age-related macular degeneration (geographic atrophy); CRC cis rs7224685 0.569 rs8065660 chr17:4000858 A/G cg05562828 chr17:3906858 NA 0.49 6.48 0.34 3.32e-10 Type 2 diabetes; CRC cis rs10504229 0.683 rs56192850 chr8:58135356 A/G cg05313129 chr8:58192883 C8orf71 -0.43 -6.11 -0.32 2.74e-9 Developmental language disorder (linguistic errors); CRC cis rs9287719 0.601 rs1861299 chr2:10763757 C/G cg00105475 chr2:10696890 NA 0.46 7.12 0.37 6.69e-12 Prostate cancer; CRC cis rs734999 0.588 rs6668149 chr1:2558308 A/C cg20673091 chr1:2541236 MMEL1 -0.37 -5.9 -0.31 9.25e-9 Ulcerative colitis; CRC trans rs10983614 1.000 rs7867776 chr9:120072627 A/G cg13093793 chr14:35099518 SNX6 0.46 6.57 0.34 2.01e-10 Survival in pancreatic cancer; CRC cis rs7618501 1.000 rs9859153 chr3:49807085 G/T cg24308560 chr3:49941425 MST1R -0.47 -7.44 -0.38 8.95e-13 Intelligence (multi-trait analysis); CRC trans rs12432203 1.000 rs78769565 chr14:51726384 A/T cg14592830 chr9:122318704 NA 0.61 6.28 0.33 1.08e-9 Cancer; CRC cis rs2455601 1.000 rs72632952 chr11:8917976 T/C cg09997546 chr11:8931473 C11orf17;ST5 -0.52 -6.87 -0.35 3.26e-11 Schizophrenia; CRC cis rs6951245 1.000 rs77868187 chr7:1093968 A/C cg20603222 chr7:1096387 C7orf50;GPR146 -0.73 -8.79 -0.44 8.53e-17 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs7216064 1.000 rs2046323 chr17:65849927 T/G cg12091567 chr17:66097778 LOC651250 -0.68 -7.87 -0.4 5.31e-14 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CRC cis rs3096299 0.658 rs34590044 chr16:89543157 A/C cg00750074 chr16:89608354 SPG7 -0.47 -7.27 -0.37 2.71e-12 Multiple myeloma (IgH translocation); CRC cis rs10504229 0.683 rs1495865 chr8:58141160 T/G cg04204079 chr8:58130323 NA -0.45 -5.78 -0.3 1.71e-8 Developmental language disorder (linguistic errors); CRC cis rs270601 0.955 rs273911 chr5:131661526 C/G cg02033258 chr5:131593261 PDLIM4 0.38 6.51 0.34 2.79e-10 Acylcarnitine levels; CRC cis rs4237845 0.611 rs7136981 chr12:58342677 A/G cg02175503 chr12:58329896 NA 0.77 12.22 0.56 1.39e-28 Intelligence (multi-trait analysis); CRC cis rs1577917 1.000 rs12216203 chr6:86675301 G/A cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.53 -6.61 -0.34 1.53e-10 Response to antipsychotic treatment; CRC cis rs73206853 0.841 rs11829321 chr12:110864593 C/G cg12870014 chr12:110450643 ANKRD13A 0.76 8.18 0.41 6.33e-15 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg26496372 chr5:37379396 WDR70 0.49 6.21 0.32 1.59e-9 Thyroid stimulating hormone; CRC cis rs8072100 0.840 rs2136751 chr17:45456093 A/G cg08085267 chr17:45401833 C17orf57 -0.67 -11.16 -0.52 9.58e-25 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs977987 0.933 rs4888431 chr16:75500699 G/T cg03315344 chr16:75512273 CHST6 0.55 9.3 0.46 1.99e-18 Dupuytren's disease; CRC cis rs1005277 0.505 rs1208689 chr10:38097775 C/G cg00409905 chr10:38381863 ZNF37A -0.62 -10.34 -0.5 6.78e-22 Extrinsic epigenetic age acceleration; CRC cis rs704795 0.867 rs7566052 chr2:27628635 A/G cg12648201 chr2:27665141 KRTCAP3 -0.3 -5.94 -0.31 7.33e-9 Menopause (age at onset); CRC cis rs6938 0.618 rs1133323 chr15:75212225 C/T cg09165964 chr15:75287851 SCAMP5 0.56 8.61 0.43 3.02e-16 Breast cancer; CRC cis rs8060686 0.858 rs2008173 chr16:67856240 A/G cg07125278 chr16:67683757 RLTPR -0.47 -6.53 -0.34 2.42e-10 HDL cholesterol;Metabolic syndrome; CRC cis rs9467711 0.606 rs4634439 chr6:26598004 C/T cg16898833 chr6:26189333 HIST1H4D -0.83 -7.24 -0.37 3.25e-12 Autism spectrum disorder or schizophrenia; CRC cis rs7731657 0.537 rs973901 chr5:130362623 G/T cg08523029 chr5:130500466 HINT1 -0.45 -5.96 -0.31 6.37e-9 Fasting plasma glucose; CRC cis rs2227564 0.620 rs3911887 chr10:75548026 A/G cg16540259 chr10:75572220 NDST2 0.51 7.86 0.4 5.61e-14 Crohn's disease;Inflammatory bowel disease; CRC cis rs1707322 0.685 rs28617418 chr1:46189526 T/A cg06784218 chr1:46089804 CCDC17 0.66 12.27 0.56 9.04e-29 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs35110281 0.805 rs4818855 chr21:45038951 C/T cg01579765 chr21:45077557 HSF2BP -0.32 -6.13 -0.32 2.47e-9 Mean corpuscular volume; CRC cis rs853679 0.517 rs4711165 chr6:28115184 T/G cg15845792 chr6:28175446 NA 1.04 13.89 0.61 7.67e-35 Depression; CRC cis rs7043114 0.525 rs7853859 chr9:95151377 A/G cg13798575 chr9:95087839 CENPP;NOL8 -0.4 -5.95 -0.31 6.87e-9 Height; CRC cis rs17162190 0.698 rs2290588 chr1:26797508 C/T cg17456097 chr1:26900765 RPS6KA1 0.47 6.62 0.34 1.5e-10 Mean corpuscular volume; CRC cis rs1788820 0.917 rs1788785 chr18:21142340 T/C cg14672496 chr18:21087552 C18orf8 0.52 9.02 0.45 1.56e-17 Body mass index; CRC cis rs7737355 0.755 rs1151481 chr5:130926374 A/C cg25547332 chr5:131281432 NA 0.39 5.93 0.31 7.53e-9 Life satisfaction; CRC cis rs11190604 1.000 rs4917901 chr10:102201773 A/C cg16342193 chr10:102329863 NA -0.37 -6.17 -0.32 2.02e-9 Palmitoleic acid (16:1n-7) levels; CRC cis rs8062405 0.965 rs56040780 chr16:28861881 C/T cg08761264 chr16:28874980 SH2B1 -0.44 -5.84 -0.31 1.27e-8 Cognitive ability (multi-trait analysis);Cognitive ability; CRC cis rs9902453 0.845 rs62068583 chr17:28001482 C/T cg26525008 chr17:28256777 EFCAB5;SSH2 0.6 8.94 0.44 2.95e-17 Coffee consumption (cups per day); CRC cis rs2396545 0.680 rs35467761 chr11:571568 A/G cg09218773 chr11:619014 MUPCDH -0.4 -5.72 -0.3 2.41e-8 Systemic lupus erythematosus and Systemic sclerosis; CRC cis rs853679 0.517 rs1853097 chr6:28058635 A/G cg25164649 chr6:28176230 NA 0.75 9.36 0.46 1.32e-18 Depression; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg12528394 chr19:59056208 TRIM28 0.44 6.01 0.31 5.05e-9 Anxiety disorder; CRC cis rs9733 0.628 rs72700895 chr1:150626029 C/T cg15448220 chr1:150897856 SETDB1 0.45 6.43 0.33 4.42e-10 Tonsillectomy; CRC cis rs35520189 0.523 rs66591921 chr2:113707577 G/A cg12858261 chr2:113808755 IL1F8 0.46 5.89 0.31 9.77e-9 Obstructive sleep apnea trait (apnea hypopnea index); CRC cis rs9311474 0.508 rs3796353 chr3:52593230 C/T cg05573699 chr3:52720067 GNL3;PBRM1 -0.44 -6.45 -0.33 4.06e-10 Electroencephalogram traits; CRC cis rs3008870 1.000 rs1925412 chr1:67405057 G/A cg08660285 chr1:67390436 MIER1;WDR78 1.01 14.78 0.63 2.99e-38 Lymphocyte percentage of white cells; CRC cis rs7249142 0.573 rs2238668 chr19:19282597 A/G cg12558012 chr19:19281197 LOC729991-MEF2B;MEF2B 0.59 9.36 0.46 1.27e-18 IgG glycosylation; CRC cis rs1152591 0.811 rs1255984 chr14:64654431 C/T cg23250157 chr14:64679961 SYNE2 -0.49 -7.56 -0.38 4.04e-13 Atrial fibrillation; CRC cis rs17376456 0.825 rs17372057 chr5:93071916 C/A cg21475434 chr5:93447410 FAM172A 0.67 6.71 0.35 8.51e-11 Diabetic retinopathy; CRC cis rs4889855 0.505 rs8077626 chr17:78600552 G/C cg16591659 chr17:78472290 NA -0.43 -6.23 -0.33 1.39e-9 Fractional excretion of uric acid; CRC cis rs1448094 0.765 rs4919773 chr12:86337559 C/T cg02569458 chr12:86230093 RASSF9 0.46 7.79 0.39 8.84e-14 Major depressive disorder; CRC cis rs798554 1.000 rs798545 chr7:2762386 C/T cg21192091 chr7:2758800 NA -0.35 -5.76 -0.3 1.97e-8 Height; CRC cis rs2404602 0.716 rs67204011 chr15:76846555 C/T cg22467129 chr15:76604101 ETFA -0.39 -6.43 -0.33 4.59e-10 Blood metabolite levels; CRC cis rs10771511 1 rs10771511 chr12:29437217 T/C cg09582351 chr12:29534625 ERGIC2 -0.29 -6.26 -0.33 1.21e-9 Platelet distribution width; CRC cis rs79839061 0.610 rs11732965 chr4:869359 C/A cg14530993 chr4:882597 GAK 0.82 7.8 0.4 8.21e-14 Intelligence (multi-trait analysis); CRC cis rs9303280 0.806 rs12232497 chr17:38040119 T/C cg20243544 chr17:37824526 PNMT 0.37 5.68 0.3 2.9e-8 Self-reported allergy; CRC cis rs1552244 0.572 rs67227131 chr3:10172744 G/A cg18598329 chr3:10140678 FANCD2;C3orf24 -0.86 -8.92 -0.44 3.29e-17 Alzheimer's disease; CRC cis rs68170813 0.559 rs6947675 chr7:106817184 T/C cg02696742 chr7:106810147 HBP1 -0.64 -7.29 -0.37 2.38e-12 Coronary artery disease; CRC cis rs9322193 0.847 rs9505972 chr6:150096391 A/C cg07701084 chr6:150067640 NUP43 0.58 7.94 0.4 3.29e-14 Lung cancer; CRC cis rs929354 0.772 rs3802126 chr7:156970281 G/A cg16102536 chr7:156981717 UBE3C 0.4 6.69 0.35 9.57e-11 Body mass index; CRC trans rs4650994 0.524 rs2761465 chr1:178579404 G/T cg05059571 chr16:84539110 KIAA1609 0.62 8.45 0.42 9.86e-16 HDL cholesterol levels;HDL cholesterol; CRC cis rs7589728 0.563 rs78685993 chr2:88447026 T/C cg18490616 chr2:88469792 THNSL2 0.61 6.1 0.32 2.9e-9 Plasma clusterin levels; CRC cis rs9287719 0.901 rs55861579 chr2:10763340 T/A cg00105475 chr2:10696890 NA 0.46 7.42 0.38 1.02e-12 Prostate cancer; CRC cis rs1950626 0.833 rs35151884 chr14:101394196 A/G cg02351406 chr14:101447389 SNORD114-20;SNORD114-21 0.95 15.88 0.66 1.56e-42 Pelvic organ prolapse (moderate/severe); CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg06604058 chr11:63448992 RTN3 0.44 7.28 0.37 2.55e-12 Obesity-related traits; CRC cis rs9916302 0.571 rs28799952 chr17:37533056 C/T cg07936489 chr17:37558343 FBXL20 0.92 11.73 0.54 9.09e-27 Glomerular filtration rate (creatinine); CRC cis rs7666738 0.830 rs17558193 chr4:99049593 A/G cg17366294 chr4:99064904 C4orf37 0.45 7.75 0.39 1.16e-13 Colonoscopy-negative controls vs population controls; CRC cis rs9486715 0.867 rs211159 chr6:97023026 G/A cg06623918 chr6:96969491 KIAA0776 -0.97 -17.63 -0.7 1.84e-49 Headache; CRC cis rs1401999 0.966 rs2037379 chr3:183650330 T/C cg05044414 chr3:183734942 ABCC5 0.48 8.18 0.41 6.13e-15 Anterior chamber depth; CRC trans rs747782 0.527 rs3741410 chr11:48168664 A/C cg03929089 chr4:120376271 NA 0.58 6.1 0.32 2.91e-9 Intraocular pressure; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg22024508 chr19:16771032 TMEM38A;C19orf42 0.48 6.13 0.32 2.56e-9 Thyroid stimulating hormone; CRC cis rs10504229 0.954 rs114134184 chr8:58181969 G/A cg24829409 chr8:58192753 C8orf71 -0.68 -11.34 -0.53 2.27e-25 Developmental language disorder (linguistic errors); CRC cis rs1107366 0.750 rs9825571 chr3:125900161 A/G cg20988073 chr3:125900093 ALDH1L1 -0.44 -7.44 -0.38 8.65e-13 Metabolite levels; CRC cis rs72945132 0.607 rs67767222 chr11:70121610 T/A cg00319359 chr11:70116639 PPFIA1 0.68 7.5 0.38 6.05e-13 Coronary artery disease; CRC cis rs798554 0.759 rs1182189 chr7:2869522 G/A cg17321639 chr7:2759063 NA -0.51 -6.68 -0.35 1.02e-10 Height; CRC cis rs847577 0.722 rs7790736 chr7:97713039 G/A cg00277769 chr7:97922759 BAIAP2L1 -0.42 -7.04 -0.36 1.1e-11 Breast cancer; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg21959036 chr4:129733057 PHF17 0.44 7.73 0.39 1.31e-13 Liver disease severity in Alagille syndrome; CRC cis rs8058578 0.943 rs7197770 chr16:30715908 T/C cg00531865 chr16:30841666 NA -0.45 -6.13 -0.32 2.58e-9 Multiple myeloma; CRC cis rs4242434 0.698 rs10104039 chr8:22538384 A/G cg03733263 chr8:22462867 KIAA1967 -0.73 -11.52 -0.54 5.11e-26 Exploratory eye movement dysfunction in schizophrenia (cognitive search score); CRC cis rs12791968 1.000 rs1552300 chr11:45002594 G/A cg11846598 chr11:44996168 LOC221122 -0.71 -12.37 -0.56 4.08e-29 Inhibitory control; CRC cis rs13161895 1.000 rs34603792 chr5:179459287 A/G cg02702477 chr5:179499311 RNF130 0.54 6.22 0.32 1.5e-9 LDL cholesterol; CRC cis rs2404602 0.692 rs59088060 chr15:76859974 T/C cg03037974 chr15:76606532 NA 0.66 11.44 0.53 9.38e-26 Blood metabolite levels; CRC cis rs1862618 0.573 rs832532 chr5:56221938 T/C cg18230493 chr5:56204884 C5orf35 -0.87 -11.75 -0.54 7.38e-27 Initial pursuit acceleration; CRC cis rs2832191 1.000 rs2832191 chr21:30489300 A/C cg24692254 chr21:30365293 RNF160 -0.64 -10.99 -0.52 3.89e-24 Dental caries; CRC cis rs860295 0.812 rs3820594 chr1:155829511 C/T cg02153340 chr1:155202674 NA -0.5 -5.98 -0.31 5.7e-9 Body mass index; CRC cis rs72634258 0.945 rs12735338 chr1:8078569 T/C cg26816564 chr1:7831052 VAMP3 0.54 6.07 0.32 3.6e-9 Inflammatory bowel disease; CRC cis rs9649465 1.000 rs1006764 chr7:123337873 C/T cg03229431 chr7:123269106 ASB15 -0.36 -5.64 -0.3 3.7e-8 Migraine; CRC cis rs2070677 0.935 rs11101869 chr10:135400631 C/T cg16964102 chr10:135390573 NA 0.53 7.44 0.38 8.95e-13 Gout; CRC cis rs7674212 0.539 rs2866635 chr4:104121576 G/A cg16532752 chr4:104119610 CENPE -0.41 -5.81 -0.31 1.45e-8 Type 2 diabetes; CRC cis rs4975709 0.589 rs1466606 chr5:1865055 C/T cg15595755 chr5:1867978 NA 0.39 6.42 0.33 4.66e-10 Cardiovascular disease risk factors; CRC cis rs1165668 0.785 rs1165681 chr12:104325111 A/G cg21863207 chr12:104234989 NT5DC3 -0.43 -6.5 -0.34 2.97e-10 Coronary heart disease (SNP X SNP interaction); CRC cis rs7927592 0.913 rs7127948 chr11:68363062 G/A cg16797656 chr11:68205561 LRP5 0.36 5.73 0.3 2.27e-8 Total body bone mineral density; CRC trans rs6472235 0.837 rs10104877 chr8:66932244 C/T cg07884673 chr3:53033167 SFMBT1 -0.45 -6.03 -0.32 4.47e-9 Myopia (pathological);Plateletcrit; CRC trans rs7267979 1.000 rs6115159 chr20:25350944 T/C cg17903999 chr18:56338584 MALT1 0.42 6.94 0.36 2.03e-11 Liver enzyme levels (alkaline phosphatase); CRC trans rs6686842 0.864 rs6662279 chr1:41553561 T/C cg19787969 chr8:9763211 NA 0.29 6.13 0.32 2.57e-9 Height; CRC cis rs9303280 0.517 rs12939566 chr17:38038390 A/T cg00129232 chr17:37814104 STARD3 -0.43 -6.91 -0.36 2.47e-11 Self-reported allergy; CRC cis rs172166 0.694 rs188105 chr6:28071393 C/T cg15845792 chr6:28175446 NA 0.79 11.71 0.54 1.05e-26 Cardiac Troponin-T levels; CRC cis rs992157 0.798 rs12053514 chr2:219167965 C/T cg04880052 chr2:219191631 PNKD -0.44 -6.93 -0.36 2.27e-11 Colorectal cancer; CRC cis rs801193 0.569 rs2659892 chr7:66200305 A/G cg11764359 chr7:65958608 NA 0.59 8.85 0.44 5.43e-17 Aortic root size; CRC cis rs514406 0.679 rs11585495 chr1:53244331 T/C cg24675658 chr1:53192096 ZYG11B 0.79 12.27 0.56 9.13e-29 Monocyte count; CRC cis rs55794721 0.509 rs6699113 chr1:25777743 C/T cg27572855 chr1:25598939 RHD 0.37 6.58 0.34 1.86e-10 Plateletcrit;Mean corpuscular volume; CRC cis rs6502050 0.835 rs6502069 chr17:80112599 G/T cg22110888 chr17:80059540 CCDC57 0.4 6.44 0.33 4.17e-10 Life satisfaction; CRC cis rs2439831 0.702 rs2467402 chr15:44024490 A/C cg15269541 chr15:43626905 ADAL 0.45 5.72 0.3 2.35e-8 Lung cancer in ever smokers; CRC cis rs10479542 0.583 rs4131080 chr5:179044292 G/A cg22764044 chr5:178986830 RUFY1 0.41 6.6 0.34 1.61e-10 Lung cancer; CRC trans rs1728785 0.901 rs1631910 chr16:68603335 G/A cg04657470 chr2:198365150 HSPE1;HSPD1 0.59 7.14 0.37 6.11e-12 Ulcerative colitis; CRC cis rs12497850 0.797 rs61583136 chr3:49189195 C/T cg07636037 chr3:49044803 WDR6 0.97 15.64 0.65 1.34e-41 Parkinson's disease; CRC cis rs854572 0.870 rs757158 chr7:94955528 C/T cg17330251 chr7:94953956 PON1 -0.77 -13.1 -0.59 7.42e-32 Paraoxonase activity; CRC cis rs965469 0.779 rs6051785 chr20:3339199 C/T cg25506879 chr20:3388711 C20orf194 -0.37 -5.68 -0.3 2.92e-8 IFN-related cytopenia; CRC cis rs911555 0.755 rs4906329 chr14:103942669 A/G cg12935359 chr14:103987150 CKB 0.56 8.91 0.44 3.55e-17 Intelligence (multi-trait analysis); CRC cis rs10504229 1.000 rs60231757 chr8:58169937 T/C cg22535103 chr8:58192502 C8orf71 -0.82 -12.27 -0.56 9.63e-29 Developmental language disorder (linguistic errors); CRC cis rs9399137 0.507 rs35571217 chr6:135290355 T/C cg24558204 chr6:135376177 HBS1L 0.6 8.9 0.44 3.88e-17 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; CRC cis rs1150668 0.768 rs1233713 chr6:28198281 A/G cg21251018 chr6:28226885 NKAPL 0.57 10.16 0.49 2.8e-21 Pubertal anthropometrics; CRC cis rs3733585 0.699 rs7683283 chr4:9969974 T/C cg00071950 chr4:10020882 SLC2A9 -0.54 -9.65 -0.47 1.47e-19 Cleft plate (environmental tobacco smoke interaction); CRC trans rs2797160 1.000 rs6904992 chr6:126016003 G/A cg05039488 chr6:79577232 IRAK1BP1 0.51 7.59 0.39 3.37e-13 Endometrial cancer; CRC cis rs2688608 0.592 rs7909802 chr10:75484186 G/C cg16540259 chr10:75572220 NDST2 0.38 5.98 0.31 5.91e-9 Inflammatory bowel disease; CRC cis rs1552244 0.572 rs58862481 chr3:10164308 G/A cg00166722 chr3:10149974 C3orf24 0.69 8.15 0.41 7.57e-15 Alzheimer's disease; CRC cis rs897984 0.647 rs7203999 chr16:31017554 T/C cg00531865 chr16:30841666 NA 0.44 6.21 0.32 1.59e-9 Dementia with Lewy bodies; CRC cis rs1552244 0.572 rs73117481 chr3:10160132 C/T cg16606324 chr3:10149918 C3orf24 0.66 7.74 0.39 1.19e-13 Alzheimer's disease; CRC cis rs7546094 1.000 rs6669096 chr1:113132361 T/C cg22162597 chr1:113214053 CAPZA1 0.43 6.08 0.32 3.3e-9 Platelet distribution width; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg26383936 chr5:39075183 RICTOR -0.4 -5.98 -0.31 5.8e-9 Myopia (pathological); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg20891225 chr3:57994481 FLNB 0.36 6.26 0.33 1.21e-9 Intelligence (multi-trait analysis); CRC cis rs951366 0.789 rs864783 chr1:205711974 T/C cg07157834 chr1:205819609 PM20D1 0.77 11.53 0.54 4.59e-26 Menarche (age at onset); CRC trans rs6500957 0.920 rs17648524 chr16:7459683 C/G cg12474759 chr6:26027625 HIST1H4B 0.42 6.04 0.32 4.23e-9 Spherical equivalent (joint analysis main effects and education interaction); CRC cis rs2249694 1.000 rs4363513 chr10:135355534 A/G cg20169779 chr10:135381914 SYCE1 0.59 9.5 0.46 4.48e-19 Obesity-related traits; CRC cis rs11864453 0.680 rs8047377 chr16:72148339 T/C cg01557791 chr16:72042693 DHODH -0.43 -6.18 -0.32 1.95e-9 Fibrinogen levels; CRC cis rs5167 0.504 rs3760628 chr19:45457225 G/A cg13119609 chr19:45449297 APOC2 0.31 5.9 0.31 9.2e-9 Blood protein levels; CRC cis rs78707713 0.512 rs12772559 chr10:71184356 C/G cg12610070 chr10:71211762 TSPAN15 -0.41 -7.31 -0.37 1.99e-12 Venous thromboembolism; CRC cis rs7666738 0.830 rs10011009 chr4:98981749 G/A cg17366294 chr4:99064904 C4orf37 0.43 7.21 0.37 3.91e-12 Colonoscopy-negative controls vs population controls; CRC cis rs10256972 0.786 rs3735686 chr7:1062527 G/A cg03923535 chr7:1197113 ZFAND2A 0.46 6.41 0.33 4.93e-10 Longevity;Endometriosis; CRC cis rs9733 0.519 rs11807450 chr1:150677719 C/T cg17724175 chr1:150552817 MCL1 0.61 9.75 0.47 6.69e-20 Tonsillectomy; CRC cis rs1451375 0.698 rs11238226 chr7:50645827 A/G cg14593290 chr7:50529359 DDC 0.52 7.25 0.37 2.92e-12 Malaria; CRC cis rs897984 0.806 rs10782002 chr16:30946506 A/G cg00531865 chr16:30841666 NA 0.49 6.83 0.35 4.03e-11 Dementia with Lewy bodies; CRC trans rs7618501 1.000 rs11716575 chr3:49744890 A/G cg21659725 chr3:3221576 CRBN -0.91 -17.91 -0.7 1.52e-50 Intelligence (multi-trait analysis); CRC cis rs12135062 1.000 rs12135062 chr1:3103312 A/C cg00254258 chr1:3105189 PRDM16 0.54 9.37 0.46 1.16e-18 Migraine; CRC cis rs8077889 0.917 rs4793037 chr17:41914826 C/T cg26893861 chr17:41843967 DUSP3 0.92 12.02 0.55 7.64e-28 Triglycerides; CRC cis rs40363 0.723 rs8060367 chr16:3537919 C/A cg22508957 chr16:3507546 NAT15 -0.78 -8.36 -0.42 1.76e-15 Tuberculosis; CRC cis rs3790844 1.000 rs3790844 chr1:200007432 A/G cg07208853 chr1:200005219 NR5A2 0.34 8.12 0.41 9.78e-15 Pancreatic cancer; CRC cis rs394563 0.967 rs369643 chr6:149799798 A/G cg16235748 chr6:149772707 ZC3H12D -0.37 -6.51 -0.34 2.8e-10 Dupuytren's disease; CRC cis rs7224685 0.501 rs4790168 chr17:4022457 T/C cg10724054 chr17:3904396 NA 0.47 7.5 0.38 5.95e-13 Type 2 diabetes; CRC cis rs11098499 0.954 rs10006877 chr4:120242793 C/T cg09307838 chr4:120376055 NA 0.7 10.62 0.51 7.68e-23 Corneal astigmatism; CRC cis rs798554 0.704 rs798513 chr7:2782493 C/T cg19717773 chr7:2847554 GNA12 -0.4 -6.6 -0.34 1.68e-10 Height; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg14230166 chr19:1020974 C19orf6 0.49 6.8 0.35 5.02e-11 Anxiety disorder; CRC cis rs2230307 0.505 rs641458 chr1:100578672 G/C cg24955406 chr1:100503596 HIAT1 -0.56 -6.7 -0.35 9.25e-11 Carotid intima media thickness; CRC cis rs10208940 0.920 rs7571506 chr2:68836317 C/A cg12452813 chr2:68675892 NA 0.48 6.02 0.31 4.69e-9 Urate levels in lean individuals; CRC cis rs2153535 0.562 rs6901765 chr6:8455436 A/T cg21535247 chr6:8435926 SLC35B3 0.5 7.5 0.38 5.81e-13 Motion sickness; CRC cis rs929354 1.000 rs8101 chr7:157061474 A/G cg17757837 chr7:157058334 UBE3C -0.79 -14.37 -0.62 1.16e-36 Body mass index; CRC cis rs77861329 0.925 rs72964042 chr3:52088485 A/C cg08692210 chr3:52188851 WDR51A 0.87 8.39 0.42 1.5e-15 Macrophage inflammatory protein 1b levels; CRC trans rs7937682 0.855 rs7934922 chr11:111500026 T/C cg18187862 chr3:45730750 SACM1L 0.48 6.82 0.35 4.3e-11 Primary sclerosing cholangitis; CRC cis rs7208859 0.623 rs9897728 chr17:29108804 A/G cg01831904 chr17:28903510 LRRC37B2 -0.63 -6.45 -0.33 4.07e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs35306767 0.714 rs12762955 chr10:1078782 A/C cg26597838 chr10:835615 NA 0.67 9.02 0.45 1.65e-17 Eosinophil percentage of granulocytes; CRC cis rs7618915 0.571 rs6762457 chr3:52609157 G/A cg10802521 chr3:52805072 NEK4 -0.59 -9.16 -0.45 5.88e-18 Bipolar disorder; CRC cis rs11105298 0.891 rs11105319 chr12:89927177 G/A cg00757033 chr12:89920650 WDR51B 0.37 6.1 0.32 2.98e-9 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; CRC cis rs58688157 0.705 rs12795572 chr11:590999 G/A cg02461776 chr11:598696 PHRF1 0.46 5.75 0.3 2.05e-8 Systemic lupus erythematosus; CRC cis rs13108904 0.901 rs7695691 chr4:1304632 A/G cg21620606 chr4:1342894 KIAA1530 0.33 5.74 0.3 2.14e-8 Obesity-related traits; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg14799209 chr7:106809543 HBP1 0.39 6.72 0.35 7.96e-11 Liver disease severity in Alagille syndrome; CRC cis rs3741404 0.895 rs2429455 chr11:63995302 C/G cg18225595 chr11:63971243 STIP1 0.58 9.74 0.47 7.16e-20 Platelet count; CRC cis rs34779708 0.966 rs4934539 chr10:35472199 A/G cg03585969 chr10:35415529 CREM 0.55 7.44 0.38 8.91e-13 Inflammatory bowel disease;Crohn's disease; CRC cis rs282587 0.502 rs416018 chr13:113396488 G/A cg04656015 chr13:113407548 ATP11A 0.63 7.8 0.4 8.04e-14 Glycated hemoglobin levels; CRC trans rs10838798 0.523 rs2019093 chr11:48196553 G/A cg03929089 chr4:120376271 NA -0.48 -6.76 -0.35 6.44e-11 Height; CRC cis rs1552244 1.000 rs6414438 chr3:10073824 G/C cg08888203 chr3:10149979 C3orf24 0.68 9.55 0.47 3.06e-19 Alzheimer's disease; CRC cis rs7811142 1.000 rs67471932 chr7:100009985 C/G cg00814883 chr7:100076585 TSC22D4 -0.73 -9.37 -0.46 1.17e-18 Platelet count; CRC cis rs2971970 0.519 rs28566817 chr7:133628668 A/G cg03336402 chr7:133662267 EXOC4 0.63 9.64 0.47 1.5700000000000001e-19 Intelligence (multi-trait analysis); CRC cis rs8078723 0.802 rs9303283 chr17:38192633 A/G cg17467752 chr17:38218738 THRA 0.86 15.04 0.64 2.85e-39 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); CRC cis rs2839186 0.632 rs17176110 chr21:47706535 C/A cg20399509 chr21:47717575 C21orf57 -0.39 -6.5 -0.34 2.93e-10 Testicular germ cell tumor; CRC cis rs7666738 0.830 rs4345191 chr4:98945408 A/G cg05340658 chr4:99064831 C4orf37 0.61 9.54 0.47 3.45e-19 Colonoscopy-negative controls vs population controls; CRC cis rs4481887 0.893 rs7538645 chr1:248478137 C/T cg13385794 chr1:248469461 NA 0.38 6.67 0.35 1.09e-10 Common traits (Other); CRC cis rs1559088 0.842 rs12977993 chr19:33580453 T/A cg27124370 chr19:33622961 WDR88 0.45 6.19 0.32 1.74e-9 Bone ultrasound measurement (broadband ultrasound attenuation); CRC cis rs6951245 0.554 rs58210047 chr7:1149381 G/A cg20603222 chr7:1096387 C7orf50;GPR146 -0.46 -5.9 -0.31 8.79e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs1728785 1.000 rs889561 chr16:68605741 G/A cg02972257 chr16:68554789 NA -0.66 -7.89 -0.4 4.55e-14 Ulcerative colitis; CRC cis rs2949837 0.581 rs2960434 chr7:45972977 A/G cg21268650 chr7:45961089 IGFBP3 0.36 6.12 0.32 2.66e-9 Sitting height ratio; CRC cis rs7937682 0.663 rs7116280 chr11:111659111 T/C cg09085632 chr11:111637200 PPP2R1B 0.97 15.36 0.65 1.65e-40 Primary sclerosing cholangitis; CRC cis rs734999 0.611 rs10797431 chr1:2501222 G/T cg18854424 chr1:2615690 NA 0.36 6.72 0.35 8.1e-11 Ulcerative colitis; CRC cis rs11711311 0.747 rs9882193 chr3:113349451 C/T cg06805542 chr3:113465803 ATP6V1A;NAA50 0.49 6.82 0.35 4.33e-11 IgG glycosylation; CRC cis rs763121 0.853 rs3761454 chr22:39066820 C/T cg06022373 chr22:39101656 GTPBP1 0.79 12.7 0.57 2.49e-30 Menopause (age at onset); CRC cis rs875971 0.545 rs2707851 chr7:66089165 C/T cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.58 -7.44 -0.38 8.95e-13 Aortic root size; CRC cis rs9322193 1.000 rs9377229 chr6:149928791 C/T cg13206674 chr6:150067644 NUP43 0.58 8.37 0.42 1.7e-15 Lung cancer; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg24835014 chr4:76911891 SDAD1 0.45 6.21 0.32 1.62e-9 Anxiety disorder; CRC cis rs7618501 0.602 rs2245365 chr3:50097319 C/A cg24308560 chr3:49941425 MST1R 0.51 8.25 0.41 3.73e-15 Intelligence (multi-trait analysis); CRC cis rs873946 0.586 rs12782567 chr10:134576709 C/G cg27286337 chr10:134555280 INPP5A -0.77 -9.37 -0.46 1.2e-18 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CRC cis rs11122272 0.735 rs2808597 chr1:231532351 T/C cg06096015 chr1:231504339 EGLN1 0.41 6.04 0.32 4.05e-9 Hemoglobin concentration; CRC cis rs9616064 0.853 rs7284865 chr22:46996529 C/T cg05621596 chr22:47072043 GRAMD4 -0.53 -8.07 -0.41 1.3e-14 Urate levels in obese individuals; CRC cis rs7666738 0.830 rs13147195 chr4:98893334 G/T cg05340658 chr4:99064831 C4orf37 0.57 8.55 0.43 4.87e-16 Colonoscopy-negative controls vs population controls; CRC cis rs593982 1.000 rs470360 chr11:65500530 T/C cg08755490 chr11:65554678 OVOL1 1.2 18.64 0.72 2.04e-53 Atopic dermatitis; CRC trans rs61931739 0.517 rs7486246 chr12:34526419 T/G cg13010199 chr12:38710504 ALG10B 0.45 6.52 0.34 2.6e-10 Morning vs. evening chronotype; CRC cis rs7044106 0.791 rs10985000 chr9:123484115 A/G cg09419670 chr9:123605666 PSMD5;LOC253039 0.73 11.99 0.55 9.92e-28 Hip circumference adjusted for BMI; CRC cis rs13064411 0.696 rs6798938 chr3:113218206 C/T cg10517650 chr3:113235015 CCDC52 -0.41 -7.26 -0.37 2.82e-12 Response to simvastatin treatment (PCSK9 protein level change); CRC trans rs9858542 0.953 rs9818590 chr3:49525096 A/G cg21665057 chr3:196295764 WDR53;FBXO45 -0.66 -9.1 -0.45 8.6e-18 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs1707322 1.000 rs4660331 chr1:46458783 A/C cg03146154 chr1:46216737 IPP 0.51 7.16 0.37 5.18e-12 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs10191773 0.535 rs11685514 chr2:113100014 C/T cg24977338 chr2:113188963 RGPD8;RGPD5 -0.63 -5.93 -0.31 7.51e-9 Yeast infection; CRC cis rs7659604 1.000 rs28640980 chr4:122664284 T/C cg20573242 chr4:122745356 CCNA2 0.42 6.24 0.33 1.33e-9 Type 2 diabetes; CRC cis rs9914988 0.943 rs9890155 chr17:27125467 A/G cg16670446 chr17:27188758 MIR451;MIR144 0.55 8.52 0.43 5.75e-16 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs10504229 0.775 rs10504228 chr8:58162053 T/G cg02725872 chr8:58115012 NA -0.59 -9.12 -0.45 7.51e-18 Developmental language disorder (linguistic errors); CRC cis rs28386778 0.897 rs7221853 chr17:61859836 A/G cg06601766 chr17:61851465 DDX42;CCDC47 0.46 6.22 0.32 1.51e-9 Prudent dietary pattern; CRC cis rs9303401 0.659 rs35928756 chr17:56702652 C/T cg10487724 chr17:56770010 TEX14;RAD51C 0.78 9.69 0.47 1.07e-19 Cognitive test performance; CRC cis rs460214 0.528 rs6517474 chr21:40023133 G/A cg21578987 chr21:40029669 ERG 0.39 5.67 0.3 3.18e-8 Response to cognitive-behavioural therapy in anxiety disorder; CRC trans rs875971 0.545 rs73142245 chr7:65691649 A/G cg02869306 chr7:64672164 INTS4L1 -0.42 -6.12 -0.32 2.59e-9 Aortic root size; CRC trans rs929596 0.561 rs7564935 chr2:234645186 G/T cg14520829 chr3:18390388 SATB1 0.42 5.98 0.31 5.76e-9 Total bilirubin levels in HIV-1 infection; CRC cis rs642858 0.956 rs646747 chr6:140280368 T/C cg27524944 chr6:140295369 NA 0.34 5.63 0.3 3.83e-8 Type 2 diabetes; CRC cis rs8072100 0.701 rs8078309 chr17:45774072 T/C cg08550205 chr17:45786854 TBKBP1 -0.35 -5.62 -0.3 3.98e-8 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs4423214 0.879 rs1630498 chr11:71150785 A/C cg13043300 chr11:71146211 DHCR7 -0.46 -6.35 -0.33 7.16e-10 Vitamin D levels; CRC cis rs904251 0.561 rs4714070 chr6:37473198 C/T cg25019722 chr6:37503610 NA -0.38 -6.59 -0.34 1.75e-10 Cognitive performance; CRC cis rs11098499 0.954 rs11722872 chr4:120233030 G/C cg24375607 chr4:120327624 NA 0.48 7.3 0.37 2.17e-12 Corneal astigmatism; CRC trans rs7618501 1.000 rs11130218 chr3:49752372 C/T cg21665057 chr3:196295764 WDR53;FBXO45 -0.86 -15.76 -0.66 4.38e-42 Intelligence (multi-trait analysis); CRC cis rs9393692 0.645 rs766407 chr6:26319534 T/C cg00631329 chr6:26305371 NA -0.72 -12.86 -0.58 6.04e-31 Educational attainment; CRC cis rs1552244 1.000 rs6442146 chr3:10073544 C/T cg02579736 chr3:10068473 FANCD2;CIDECP 0.97 13.11 0.59 7.1e-32 Alzheimer's disease; CRC cis rs4555082 0.874 rs2816606 chr14:105716034 C/T cg18132624 chr14:105716052 BTBD6;BRF1 -0.53 -8.73 -0.43 1.29e-16 Mean platelet volume;Platelet distribution width; CRC trans rs6550704 0.687 rs9865314 chr3:22634337 A/G cg15097968 chr15:63449935 RPS27L -0.46 -7.0 -0.36 1.44e-11 Daytime sleep phenotypes; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg07208322 chr5:177027175 B4GALT7 0.39 6.32 0.33 8.45e-10 Liver disease severity in Alagille syndrome; CRC cis rs6696846 0.765 rs4394715 chr1:205108393 T/G cg03948781 chr1:205179583 DSTYK 0.41 5.91 0.31 8.43e-9 Red blood cell count; CRC cis rs9486715 0.838 rs9320127 chr6:96865358 G/A cg18709589 chr6:96969512 KIAA0776 0.47 6.89 0.35 2.9100000000000002e-11 Headache; CRC cis rs28374715 0.681 rs8037574 chr15:41630770 T/C cg18705301 chr15:41695430 NDUFAF1 -0.85 -14.29 -0.62 2.21e-36 Ulcerative colitis; CRC cis rs453301 0.686 rs10217044 chr8:8894752 A/G cg06636001 chr8:8085503 FLJ10661 -0.47 -7.13 -0.37 6.42e-12 Joint mobility (Beighton score); CRC cis rs9649213 0.593 rs1468338 chr7:97951118 T/C cg21770322 chr7:97807741 LMTK2 0.51 8.29 0.42 2.89e-15 Prostate cancer (SNP x SNP interaction); CRC cis rs7772486 0.790 rs2247429 chr6:146217769 T/C cg13319975 chr6:146136371 FBXO30 -0.43 -6.53 -0.34 2.56e-10 Lobe attachment (rater-scored or self-reported); CRC cis rs2342406 0.825 rs6704663 chr2:45140616 A/G cg23424933 chr2:45157613 NA 0.44 6.06 0.32 3.77e-9 Myopia; CRC trans rs1864729 1.000 rs2635161 chr8:98282907 A/C cg08679828 chr8:102218111 ZNF706 0.63 8.05 0.41 1.51e-14 Estradiol plasma levels (breast cancer); CRC trans rs11088226 0.681 rs4547609 chr21:33953542 G/A cg09050820 chr6:167586206 TCP10L2 0.87 8.86 0.44 4.97e-17 Gastritis; CRC cis rs6502050 0.835 rs56232956 chr17:80078929 C/T cg09264619 chr17:80180166 NA 0.37 6.13 0.32 2.47e-9 Life satisfaction; CRC cis rs6701037 0.681 rs1894709 chr1:175132371 G/T cg17845761 chr1:175162550 KIAA0040 -0.27 -5.68 -0.3 2.9e-8 Alcohol dependence; CRC cis rs17213078 0.510 rs17032713 chr2:106886839 T/C cg23109721 chr2:106886537 NA -0.46 -7.18 -0.37 4.82e-12 Facial morphology (factor 23); CRC cis rs75804782 0.581 rs3191996 chr2:239344412 A/G cg18131467 chr2:239335373 ASB1 0.68 6.18 0.32 1.95e-9 Morning vs. evening chronotype;Chronotype; CRC cis rs4731207 0.698 rs1468377 chr7:124458599 A/G cg23710748 chr7:124431027 NA 0.38 6.08 0.32 3.42e-9 Cutaneous malignant melanoma; CRC cis rs9911578 0.967 rs6503883 chr17:56917543 C/T cg12560992 chr17:57184187 TRIM37 0.92 16.91 0.68 1.29e-46 Intelligence (multi-trait analysis); CRC cis rs597539 0.690 rs647661 chr11:68625875 T/C cg06028808 chr11:68637592 NA 0.42 6.69 0.35 9.51e-11 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC trans rs877282 0.797 rs7079164 chr10:756363 A/G cg22713356 chr15:30763199 NA 1.19 13.88 0.61 8.17e-35 Uric acid levels; CRC cis rs4665809 1.000 rs4665823 chr2:26312723 A/G cg25036284 chr2:26402008 FAM59B -0.46 -6.06 -0.32 3.77e-9 Gut microbiome composition (summer); CRC cis rs6121246 0.567 rs2811 chr20:30194248 A/G cg13852791 chr20:30311386 BCL2L1 0.6 8.21 0.41 5.04e-15 Mean corpuscular hemoglobin; CRC cis rs2115630 0.645 rs6496284 chr15:85178270 A/G cg17507749 chr15:85114479 UBE2QP1 -0.41 -6.13 -0.32 2.52e-9 P wave terminal force; CRC cis rs9814567 1.000 rs13090969 chr3:134307257 C/A cg06109529 chr3:134205091 CEP63;ANAPC13 0.83 12.18 0.56 1.98e-28 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC trans rs7267979 0.789 rs4815400 chr20:25292560 T/C cg17903999 chr18:56338584 MALT1 0.43 6.92 0.36 2.38e-11 Liver enzyme levels (alkaline phosphatase); CRC cis rs1186222 0.501 rs4731227 chr7:75263700 C/T cg05145297 chr7:75264568 HIP1 0.68 12.21 0.56 1.63e-28 Basophil percentage of granulocytes;White blood cell count (basophil);Basophil percentage of white cells; CRC cis rs6952808 0.609 rs10227517 chr7:1950292 A/T cg04267008 chr7:1944627 MAD1L1 -0.62 -9.63 -0.47 1.69e-19 Bipolar disorder and schizophrenia; CRC cis rs611744 0.647 rs7015240 chr8:109262204 G/A cg21045802 chr8:109455806 TTC35 0.41 6.54 0.34 2.38e-10 Dupuytren's disease; CRC cis rs11190604 0.767 rs872290 chr10:102198879 G/A cg16342193 chr10:102329863 NA -0.34 -5.67 -0.3 3.16e-8 Palmitoleic acid (16:1n-7) levels; CRC cis rs59918340 0.728 rs10112337 chr8:142233573 A/G cg03316587 chr8:142245164 NA 0.42 6.28 0.33 1.09e-9 Immature fraction of reticulocytes; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg23330034 chr19:41770021 HNRNPUL1 0.48 6.87 0.35 3.18e-11 Response to antipsychotic treatment; CRC cis rs12142240 0.698 rs17361936 chr1:46862893 C/T cg14993813 chr1:46806288 NSUN4 -0.48 -6.03 -0.32 4.47e-9 Menopause (age at onset); CRC cis rs1552244 0.572 rs66514627 chr3:10166632 A/C cg16606324 chr3:10149918 C3orf24 0.66 7.74 0.39 1.19e-13 Alzheimer's disease; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg05422897 chr2:113403145 SLC20A1 0.51 6.52 0.34 2.7e-10 Thyroid stimulating hormone; CRC cis rs10751667 0.643 rs7396951 chr11:927355 G/A cg01483505 chr11:975446 AP2A2 0.43 6.87 0.35 3.26e-11 Alzheimer's disease (late onset); CRC cis rs2692947 0.832 rs2692954 chr2:96683378 T/G cg23100626 chr2:96804247 ASTL 0.27 7.2 0.37 4.21e-12 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; CRC trans rs2303319 0.504 rs56965753 chr2:162597251 A/G cg23919916 chr10:103825097 HPS6 -0.69 -6.01 -0.31 4.8e-9 Cognitive function; CRC cis rs6988636 1.000 rs13260798 chr8:124190192 G/A cg27053337 chr8:124217698 FAM83A 0.43 6.59 0.34 1.74e-10 Urinary uromodulin levels; CRC cis rs3824867 0.920 rs7108143 chr11:47453722 T/G cg05585544 chr11:47624801 NA 0.41 6.32 0.33 8.5e-10 Mean corpuscular hemoglobin; CRC cis rs1552244 1.000 rs111392584 chr3:10075991 A/G cg13047869 chr3:10149882 C3orf24 0.57 7.76 0.39 1.1e-13 Alzheimer's disease; CRC trans rs8141529 0.507 rs5762936 chr22:29381377 A/G cg08377800 chr16:31885014 ZNF267 0.62 6.6 0.34 1.65e-10 Lymphocyte counts; CRC trans rs12599106 0.770 rs12445057 chr16:34970274 C/G cg01171360 chr6:293285 DUSP22 -0.55 -7.86 -0.4 5.56e-14 Menopause (age at onset); CRC cis rs10504229 1.000 rs66886949 chr8:58187613 A/G cg05313129 chr8:58192883 C8orf71 -0.47 -6.99 -0.36 1.49e-11 Developmental language disorder (linguistic errors); CRC cis rs35110281 0.713 rs1378079 chr21:45011187 A/G cg04455712 chr21:45112962 RRP1B 0.41 7.97 0.4 2.71e-14 Mean corpuscular volume; CRC cis rs364477 0.811 rs279882 chr9:984779 G/T cg13952963 chr9:998547 NA 0.47 5.63 0.3 3.96e-8 Major depressive disorder; CRC cis rs7208859 0.623 rs11656844 chr17:29060597 G/T cg13385521 chr17:29058706 SUZ12P 0.7 7.87 0.4 5.18e-14 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs2228479 0.850 rs12597299 chr16:89822364 C/A cg19635926 chr16:89946313 TCF25 0.63 5.68 0.3 3.01e-8 Skin colour saturation; CRC cis rs6563739 0.655 rs1028671 chr13:40220011 A/G cg00026919 chr13:40226031 NA -0.44 -5.61 -0.3 4.36e-8 Menarche (age at onset); CRC cis rs644148 0.676 rs2571114 chr19:44997579 A/G cg15540054 chr19:45004280 ZNF180 -0.42 -5.77 -0.3 1.79e-8 Personality dimensions; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg07681156 chr19:56154921 ZNF581 0.46 7.39 0.38 1.24e-12 Liver disease severity in Alagille syndrome; CRC cis rs10504229 0.683 rs56741275 chr8:58136108 C/G cg21724239 chr8:58056113 NA 0.49 6.81 0.35 4.75e-11 Developmental language disorder (linguistic errors); CRC cis rs9517320 1.000 rs9584857 chr13:99128572 T/C cg20487152 chr13:99095054 FARP1 0.35 5.82 0.31 1.42e-8 Longevity; CRC cis rs9527 0.615 rs2152915 chr10:104691732 A/T cg15744005 chr10:104629667 AS3MT -0.31 -6.23 -0.32 1.41e-9 Arsenic metabolism; CRC cis rs751728 1.000 rs751728 chr6:33764033 C/T cg25922239 chr6:33757077 LEMD2 0.62 9.8 0.48 4.56e-20 Crohn's disease; CRC cis rs225245 0.791 rs6505492 chr17:34026597 C/T cg05299278 chr17:33885742 SLFN14 0.51 8.22 0.41 4.9e-15 Reticulocyte count;Reticulocyte fraction of red cells;High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells; CRC cis rs896854 0.738 rs527234 chr8:95963798 C/G cg13393036 chr8:95962371 TP53INP1 0.43 6.66 0.34 1.16e-10 Type 2 diabetes; CRC cis rs7208859 0.623 rs3794796 chr17:29130880 G/C cg13385521 chr17:29058706 SUZ12P 0.76 8.63 0.43 2.74e-16 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC trans rs10242455 0.850 rs57367781 chr7:99116819 G/A cg09045935 chr12:6379348 NA 1.14 8.78 0.44 9.15e-17 Blood metabolite levels; CRC trans rs561341 1.000 rs1557731 chr17:30321567 T/G cg27661571 chr11:113659931 NA -0.7 -8.75 -0.43 1.15e-16 Hip circumference adjusted for BMI; CRC cis rs644799 0.710 rs10831433 chr11:95519787 C/T cg25622487 chr11:95524042 FAM76B;CEP57 0.81 13.52 0.6 2.07e-33 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs798554 0.836 rs798526 chr7:2775542 G/C cg19346786 chr7:2764209 NA -0.41 -7.27 -0.37 2.71e-12 Height; CRC cis rs79349575 0.783 rs318095 chr17:46974734 T/C cg22482690 chr17:47019901 SNF8 0.48 8.09 0.41 1.2e-14 Type 2 diabetes; CRC cis rs6088580 0.634 rs6059897 chr20:33113224 A/G cg24642439 chr20:33292090 TP53INP2 0.4 6.6 0.34 1.61e-10 Glomerular filtration rate (creatinine); CRC cis rs703842 1.000 rs6581155 chr12:58178162 A/G cg00677455 chr12:58241039 CTDSP2 0.69 10.01 0.48 9.07e-21 Multiple sclerosis; CRC trans rs1814175 0.645 rs7952104 chr11:49964180 C/T cg03929089 chr4:120376271 NA -0.91 -15.76 -0.66 4.29e-42 Height; CRC cis rs2404602 0.716 rs4886813 chr15:76838221 C/T cg03037974 chr15:76606532 NA -0.64 -11.0 -0.52 3.65e-24 Blood metabolite levels; CRC cis rs1129187 0.837 rs3763236 chr6:42902508 C/T cg09436375 chr6:42928200 GNMT 0.31 5.8 0.3 1.52e-8 Alzheimer's disease in APOE e4+ carriers; CRC cis rs1552244 1.000 rs7622966 chr3:10139833 C/T cg13047869 chr3:10149882 C3orf24 0.51 7.34 0.37 1.72e-12 Alzheimer's disease; CRC cis rs7173389 0.530 rs6495063 chr15:73682708 G/T cg01796676 chr15:73680284 NA 0.55 8.56 0.43 4.48e-16 Resting heart rate; CRC cis rs1008375 1.000 rs2058338 chr4:17678600 A/G cg16339924 chr4:17578868 LAP3 -0.53 -6.89 -0.35 2.93e-11 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs12188164 0.965 rs56146525 chr5:442571 A/C cg17553881 chr5:443987 EXOC3;C5orf55 -0.37 -7.62 -0.39 2.82e-13 Cystic fibrosis severity; CRC cis rs950169 0.526 rs698620 chr15:85177208 G/A cg11189052 chr15:85197271 WDR73 -0.69 -11.93 -0.55 1.61e-27 Schizophrenia; CRC cis rs55692411 0.537 rs35012435 chr3:50031840 C/T cg05623727 chr3:50126028 RBM5 0.53 6.92 0.36 2.37e-11 Intelligence (multi-trait analysis); CRC trans rs9291683 0.620 rs717615 chr4:10104670 C/T cg26043149 chr18:55253948 FECH 0.51 8.03 0.4 1.75e-14 Bone mineral density; CRC cis rs6662572 0.737 rs6429590 chr1:46457250 T/C cg03123370 chr1:45965343 CCDC163P;MMACHC 0.45 5.63 0.3 3.8e-8 Blood protein levels; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg06424594 chr17:37824825 PNMT 0.45 6.07 0.32 3.56e-9 Anxiety disorder; CRC cis rs921968 0.509 rs7571743 chr2:219352572 C/T cg02176678 chr2:219576539 TTLL4 0.54 8.69 0.43 1.78e-16 Mean corpuscular hemoglobin concentration; CRC cis rs9443645 0.527 rs9359360 chr6:79702796 C/T cg09184832 chr6:79620586 NA -0.43 -7.3 -0.37 2.2e-12 Intelligence (multi-trait analysis); CRC cis rs13191362 0.507 rs6907151 chr6:163200701 T/A cg06582575 chr6:163149167 PACRG;PARK2 0.53 8.07 0.41 1.37e-14 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs12477438 0.508 rs2516832 chr2:99771268 G/C cg14399236 chr2:99771627 LIPT1;TSGA10 0.82 14.44 0.62 5.96e-37 Chronic sinus infection; CRC cis rs7923609 1.000 rs1935 chr10:64927823 C/G cg08743896 chr10:65200160 JMJD1C -0.4 -5.75 -0.3 2.06e-8 Educational attainment;Liver enzyme levels (alkaline phosphatase); CRC cis rs2991971 0.934 rs11211129 chr1:45983080 C/T cg15605315 chr1:45957053 TESK2 0.42 6.74 0.35 7.19e-11 High light scatter reticulocyte count; CRC cis rs13108904 0.967 rs13149715 chr4:1278255 C/A cg19318889 chr4:1322082 MAEA 0.4 5.74 0.3 2.13e-8 Obesity-related traits; CRC cis rs9768139 0.708 rs921615 chr7:158117935 A/G cg06219351 chr7:158114137 PTPRN2 -0.55 -8.34 -0.42 2.11e-15 Calcium levels; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg01430082 chr1:26438394 PDIK1L 0.46 6.05 0.32 4.01e-9 Anxiety disorder; CRC cis rs7615952 0.576 rs4646748 chr3:125826329 G/A cg15145296 chr3:125709740 NA -0.56 -6.65 -0.34 1.21e-10 Blood pressure (smoking interaction); CRC trans rs4263408 0.934 rs9683743 chr4:39703194 A/C cg14094063 chr7:140624470 BRAF -0.44 -6.68 -0.35 1.04e-10 Plasma amyloid beta peptide concentrations (ABx-40); CRC cis rs10883723 0.810 rs13287 chr10:104240438 A/G cg11453585 chr10:104263688 ACTR1A;SUFU 0.91 16.63 0.68 1.7e-45 Allergic disease (asthma, hay fever or eczema); CRC cis rs12477438 0.834 rs6757019 chr2:99676936 T/A cg14399236 chr2:99771627 LIPT1;TSGA10 -0.74 -10.37 -0.5 5.51e-22 Chronic sinus infection; CRC cis rs877282 0.853 rs11595510 chr10:756757 C/G cg17470449 chr10:769945 NA 0.6 7.95 0.4 2.97e-14 Uric acid levels; CRC cis rs7447593 0.626 rs3812036 chr5:176813404 C/T cg06060754 chr5:176797920 RGS14 0.64 9.13 0.45 7.07e-18 Urinary electrolytes (magnesium/calcium ratio); CRC cis rs2637266 0.561 rs7090852 chr10:78499053 A/G cg18941641 chr10:78392320 NA -0.35 -5.99 -0.31 5.4e-9 Pulmonary function; CRC cis rs8072100 0.935 rs4793978 chr17:45698175 G/A cg08085267 chr17:45401833 C17orf57 0.61 9.66 0.47 1.36e-19 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs2415984 0.558 rs10220566 chr14:46965511 A/T cg14871534 chr14:47121158 RPL10L -0.43 -6.23 -0.32 1.44e-9 Number of children ever born; CRC cis rs6815814 0.808 rs11721824 chr4:38767749 G/A cg06935464 chr4:38784597 TLR10 0.57 5.66 0.3 3.25e-8 Breast cancer; CRC cis rs6860806 0.507 rs183898 chr5:131716902 C/G cg18758796 chr5:131593413 PDLIM4 -0.41 -6.59 -0.34 1.77e-10 Breast cancer; CRC cis rs9910055 0.529 rs2523161 chr17:42179405 C/T cg10896456 chr17:42255109 ASB16;C17orf65 -0.42 -6.6 -0.34 1.6e-10 Total body bone mineral density; CRC cis rs6545883 0.929 rs6707830 chr2:61749472 G/A cg15711740 chr2:61764176 XPO1 -0.49 -6.74 -0.35 6.9e-11 Tuberculosis; CRC cis rs9611565 0.921 rs4822021 chr22:41726053 G/A cg06481639 chr22:41940642 POLR3H -0.44 -5.66 -0.3 3.22e-8 Vitiligo; CRC cis rs13315871 0.932 rs35741271 chr3:58323091 A/G cg20936604 chr3:58311152 NA -0.76 -7.27 -0.37 2.69e-12 Cholesterol, total; CRC cis rs12134245 0.874 rs34842487 chr1:92021611 C/T cg21854759 chr1:92012499 NA -0.39 -6.03 -0.32 4.45e-9 Breast cancer; CRC cis rs11764590 0.950 rs55683212 chr7:2078855 G/C cg02421172 chr7:1938701 MAD1L1 0.42 5.66 0.3 3.27e-8 Neuroticism; CRC cis rs6558530 0.932 rs6558531 chr8:1707566 A/G cg19131313 chr8:1704013 NA -0.44 -5.77 -0.3 1.81e-8 Systolic blood pressure; CRC cis rs9911578 0.935 rs12948039 chr17:57045184 C/T cg05425664 chr17:57184151 TRIM37 -0.44 -6.93 -0.36 2.24e-11 Intelligence (multi-trait analysis); CRC cis rs6761276 1.000 rs6761276 chr2:113832312 C/T cg09040174 chr2:113837401 NA -0.64 -10.51 -0.5 1.78e-22 Protein quantitative trait loci; CRC cis rs9372498 0.536 rs17424234 chr6:118808521 A/G cg15382696 chr6:118971807 C6orf204 0.56 6.96 0.36 1.84e-11 Diastolic blood pressure; CRC cis rs9303401 0.592 rs66583824 chr17:56639853 C/T cg10487724 chr17:56770010 TEX14;RAD51C 0.78 9.59 0.47 2.24e-19 Cognitive test performance; CRC trans rs11098499 0.954 rs3733520 chr4:120423480 C/G cg25214090 chr10:38739885 LOC399744 0.64 10.13 0.49 3.61e-21 Corneal astigmatism; CRC trans rs2303319 0.504 rs56274002 chr2:162536715 A/T cg18122310 chr12:50236657 BCDIN3D -0.74 -6.19 -0.32 1.81e-9 Cognitive function; CRC cis rs1178968 0.591 rs10440929 chr7:72786770 A/C cg25889504 chr7:72793014 NA 0.52 5.9 0.31 9.14e-9 Triglyceride levels; CRC cis rs737337 0.623 rs3810308 chr19:11333596 T/C cg00586551 chr19:11347513 LOC55908;DOCK6 0.79 8.85 0.44 5.52e-17 HDL cholesterol;HDL cholesterol levels; CRC cis rs9549328 0.800 rs9549617 chr13:113628070 C/A cg20742385 chr13:113633654 MCF2L -0.72 -12.59 -0.57 6.32e-30 Systolic blood pressure; CRC cis rs6761276 0.899 rs11677088 chr2:113835603 A/G cg09040174 chr2:113837401 NA 0.65 10.31 0.49 9.07e-22 Protein quantitative trait loci; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg07237882 chr5:137090689 HNRNPA0 0.4 6.41 0.33 5.07e-10 Liver disease severity in Alagille syndrome; CRC cis rs1568889 1.000 rs61236373 chr11:28212720 C/G cg06544937 chr11:28130018 METT5D1;KIF18A 0.8 11.58 0.54 3.17e-26 Bipolar disorder; CRC cis rs10256972 0.732 rs1574108 chr7:1105805 T/C cg03923535 chr7:1197113 ZFAND2A 0.58 8.19 0.41 5.69e-15 Longevity;Endometriosis; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg15012766 chr1:41832369 NA 0.41 6.07 0.32 3.62e-9 Anxiety disorder; CRC trans rs2727020 0.521 rs7101761 chr11:49598178 G/A cg15704280 chr7:45808275 SEPT13 -0.75 -9.82 -0.48 4.04e-20 Coronary artery disease; CRC cis rs4319547 1.000 rs7309390 chr12:123110422 A/G cg05707623 chr12:122985044 ZCCHC8 -0.7 -8.74 -0.43 1.26e-16 Body mass index; CRC cis rs7208859 0.623 rs9914499 chr17:29107588 G/A cg01831904 chr17:28903510 LRRC37B2 -0.63 -6.53 -0.34 2.51e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs6684514 1.000 rs12023704 chr1:156294149 C/A cg16558208 chr1:156270281 VHLL 0.58 9.0 0.44 1.9e-17 Mean corpuscular hemoglobin concentration;Glycated hemoglobin levels; CRC cis rs12681288 0.645 rs2600509 chr8:989022 C/G cg08648136 chr8:956695 NA -0.33 -6.27 -0.33 1.13e-9 Schizophrenia; CRC cis rs736408 0.540 rs4687637 chr3:52634092 C/T cg08222913 chr3:52553049 STAB1 -0.34 -6.35 -0.33 7.12e-10 Bipolar disorder; CRC cis rs6545883 0.791 rs4672445 chr2:61655008 T/C cg15711740 chr2:61764176 XPO1 0.46 6.1 0.32 3.03e-9 Tuberculosis; CRC trans rs6539288 0.803 rs10778517 chr12:107341664 G/T cg01546243 chr14:61748019 TMEM30B -0.41 -6.03 -0.32 4.35e-9 Total body bone mineral density; CRC trans rs11165623 0.602 rs6677110 chr1:97018734 A/C cg10631902 chr5:14652156 NA -0.36 -6.21 -0.32 1.57e-9 Hip circumference;Waist circumference; CRC cis rs7264396 0.563 rs2425071 chr20:34292961 A/C cg04508476 chr20:34239394 CPNE1;RBM12 0.53 7.33 0.37 1.83e-12 Total cholesterol levels; CRC trans rs9369640 0.674 rs1332845 chr6:12892456 C/T cg05562828 chr17:3906858 NA 0.41 5.99 0.31 5.57e-9 Coronary artery disease; CRC cis rs11212617 0.935 rs609655 chr11:108204253 A/G cg01991180 chr11:108092276 ATM;NPAT -0.4 -5.65 -0.3 3.47e-8 Response to metformin in type 2 diabetes (glycemic); CRC cis rs938554 0.571 rs12509955 chr4:10024303 C/T cg11266682 chr4:10021025 SLC2A9 -0.42 -6.92 -0.36 2.37e-11 Blood metabolite levels; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg17774305 chr12:50505649 C12orf62 0.49 6.89 0.36 2.79e-11 Response to antipsychotic treatment; CRC cis rs938554 0.578 rs7663032 chr4:9993838 C/T cg00071950 chr4:10020882 SLC2A9 0.46 7.13 0.37 6.6e-12 Blood metabolite levels; CRC cis rs853679 0.517 rs7755442 chr6:28039015 T/C cg25164649 chr6:28176230 NA 0.73 9.16 0.45 5.49e-18 Depression; CRC cis rs155076 0.711 rs4770129 chr13:21882059 T/G cg25811766 chr13:21894605 NA 0.57 6.77 0.35 5.88e-11 White matter hyperintensity burden; CRC cis rs501120 0.925 rs1632484 chr10:44773984 C/T cg09554077 chr10:44749378 NA 0.74 10.86 0.51 1.12e-23 Coronary artery disease;Coronary heart disease; CRC cis rs875971 0.862 rs11760844 chr7:65739883 C/G cg00343986 chr7:65444356 GUSB -0.4 -5.62 -0.3 4.07e-8 Aortic root size; CRC cis rs17784882 0.521 rs11713693 chr3:47074906 T/C cg27129171 chr3:47204927 SETD2 -0.65 -9.73 -0.47 8.11e-20 QT interval; CRC cis rs2836974 0.931 rs2735306 chr21:40713134 A/G cg11644478 chr21:40555479 PSMG1 -0.74 -10.93 -0.52 6.33e-24 Cognitive function; CRC cis rs2735413 0.918 rs7197254 chr16:78063353 C/G cg04733911 chr16:78082701 NA -0.36 -5.94 -0.31 7.41e-9 Systolic blood pressure (alcohol consumption interaction); CRC cis rs7811142 1.000 rs73405353 chr7:100091215 G/A cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.06 14.21 0.62 4.58e-36 Platelet count; CRC cis rs9911578 1.000 rs12602346 chr17:56901713 T/C cg05425664 chr17:57184151 TRIM37 -0.49 -7.72 -0.39 1.45e-13 Intelligence (multi-trait analysis); CRC trans rs208520 0.545 rs10944874 chr6:66752080 C/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.08 -20.27 -0.75 7.32e-60 Exhaled nitric oxide output; CRC trans rs61931739 0.500 rs10844829 chr12:34304916 G/T cg26384229 chr12:38710491 ALG10B 0.53 6.75 0.35 6.88e-11 Morning vs. evening chronotype; CRC cis rs1448094 0.533 rs2169572 chr12:86170370 G/T cg02569458 chr12:86230093 RASSF9 -0.46 -7.96 -0.4 2.79e-14 Major depressive disorder; CRC cis rs3862030 0.500 rs11191327 chr10:104303883 T/C cg04362960 chr10:104952993 NT5C2 -0.4 -5.7 -0.3 2.6e-8 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for body mass index; CRC trans rs6561151 0.957 rs1373904 chr13:44475398 A/G cg17145862 chr1:211918768 LPGAT1 0.49 7.04 0.36 1.15e-11 Crohn's disease; CRC cis rs911555 0.755 rs8014013 chr14:103937372 A/G cg24130564 chr14:104152367 KLC1 0.45 5.9 0.31 8.88e-9 Intelligence (multi-trait analysis); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg23868848 chr8:128806661 PVT1 0.4 6.97 0.36 1.69e-11 Liver disease severity in Alagille syndrome; CRC cis rs9491140 0.539 rs10872285 chr6:124689145 C/T cg05308643 chr6:124982296 NKAIN2 0.54 7.19 0.37 4.46e-12 Neuroticism; CRC cis rs3091242 0.967 rs1053438 chr1:25687901 T/C cg27572855 chr1:25598939 RHD -0.36 -6.36 -0.33 6.85e-10 Erythrocyte sedimentation rate; CRC cis rs1957429 0.901 rs1957434 chr14:65349909 C/T cg23373153 chr14:65346875 NA 0.79 8.25 0.41 3.9e-15 Pediatric areal bone mineral density (radius); CRC cis rs9612 1.000 rs2277745 chr19:44259077 C/T cg08581076 chr19:44259116 C19orf61 0.53 6.77 0.35 5.94e-11 Exhaled nitric oxide output; CRC cis rs7246657 0.943 rs28402338 chr19:37833923 G/A cg23950597 chr19:37808831 NA -0.54 -6.5 -0.34 2.93e-10 Coronary artery calcification; CRC cis rs2742540 0.503 rs7106539 chr11:8897533 T/G cg21881798 chr11:8931708 C11orf17;ST5 -0.43 -6.64 -0.34 1.29e-10 Hematocrit; CRC cis rs2303759 0.918 rs8107548 chr19:49870643 T/C cg22307029 chr19:49891270 CCDC155 0.7 9.93 0.48 1.69e-20 Multiple sclerosis; CRC cis rs947211 0.898 rs1775146 chr1:205756168 A/G cg14893161 chr1:205819251 PM20D1 0.42 5.62 0.3 4.06e-8 Parkinson's disease; CRC cis rs4727027 0.933 rs6961605 chr7:148870108 G/A cg23583168 chr7:148888333 NA -0.93 -16.46 -0.67 7.62e-45 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg00605358 chr12:89747739 DUSP6 -0.55 -6.67 -0.35 1.07e-10 Diisocyanate-induced asthma; CRC cis rs7208859 0.623 rs55938328 chr17:29117010 T/C cg13385521 chr17:29058706 SUZ12P 0.73 8.38 0.42 1.53e-15 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs17253792 0.822 rs77420254 chr14:56069646 C/T cg24579896 chr14:56047964 C14orf33;KTN1 0.71 5.69 0.3 2.81e-8 Putamen volume; CRC trans rs1814175 0.817 rs11040651 chr11:49938395 G/A cg03929089 chr4:120376271 NA -0.94 -17.84 -0.7 2.9e-50 Height; CRC cis rs9314323 0.964 rs2304300 chr8:26249018 G/A cg13160058 chr8:26243215 BNIP3L -0.47 -8.2 -0.41 5.49e-15 Red cell distribution width; CRC cis rs992157 0.764 rs2891076 chr2:219184398 C/T cg04880052 chr2:219191631 PNKD 0.4 6.08 0.32 3.32e-9 Colorectal cancer; CRC cis rs1448094 0.512 rs12297441 chr12:86233980 C/T cg18827107 chr12:86230957 RASSF9 -0.46 -7.64 -0.39 2.4e-13 Major depressive disorder; CRC trans rs1455244 0.700 rs7229302 chr18:11508904 G/T cg08642325 chr8:26149300 PPP2R2A 0.4 5.99 0.31 5.58e-9 Schizophrenia; CRC cis rs9355610 0.892 rs2247314 chr6:167370230 T/C cg23791538 chr6:167370224 RNASET2 0.51 8.04 0.41 1.64e-14 Graves' disease; CRC cis rs9487051 0.676 rs1608041 chr6:109595903 G/A cg12927641 chr6:109611667 NA -0.36 -6.44 -0.33 4.15e-10 Reticulocyte fraction of red cells; CRC cis rs300703 0.542 rs300691 chr2:180171 C/A cg21211680 chr2:198530 NA -0.75 -9.3 -0.46 1.96e-18 Blood protein levels; CRC cis rs58804349 0.685 rs9422448 chr10:43288816 A/G cg08461752 chr10:43522343 NA -0.78 -6.03 -0.32 4.48e-9 Pediatric bone mineral content (radius); CRC cis rs10463316 1.000 rs10463316 chr5:150746034 A/G cg03212797 chr5:150827313 SLC36A1 -0.41 -6.1 -0.32 2.96e-9 Metabolite levels (Pyroglutamine); CRC cis rs3812049 0.784 rs2250127 chr5:127388844 G/A cg25462716 chr5:127418816 SLC12A2;FLJ33630 -0.8 -9.53 -0.47 3.51e-19 Lymphocyte counts;Red cell distribution width; CRC cis rs3820068 0.581 rs72645895 chr1:15931709 G/A cg27534772 chr1:16042836 PLEKHM2 0.54 10.46 0.5 2.7e-22 Systolic blood pressure; CRC cis rs7666738 0.830 rs2015828 chr4:98984594 A/G cg17366294 chr4:99064904 C4orf37 0.43 7.29 0.37 2.37e-12 Colonoscopy-negative controls vs population controls; CRC cis rs17767392 1.000 rs7156460 chr14:71855334 A/T cg13720639 chr14:72061746 SIPA1L1 -0.54 -6.89 -0.35 2.93e-11 Mitral valve prolapse; CRC cis rs877282 0.947 rs7904978 chr10:768078 C/T cg17470449 chr10:769945 NA 0.65 8.4 0.42 1.31e-15 Uric acid levels; CRC cis rs7487075 0.619 rs6582658 chr12:46856095 G/A cg22049899 chr12:47219821 SLC38A4 0.31 5.73 0.3 2.22e-8 Itch intensity from mosquito bite; CRC cis rs10504229 0.679 rs72649115 chr8:58037631 T/G cg21724239 chr8:58056113 NA 0.73 8.87 0.44 4.88e-17 Developmental language disorder (linguistic errors); CRC cis rs11971779 0.555 rs6950143 chr7:139054418 C/T cg23387468 chr7:139079360 LUC7L2 0.41 7.04 0.36 1.14e-11 Diisocyanate-induced asthma; CRC cis rs6456156 0.586 rs2017338 chr6:167471714 G/A cg07741184 chr6:167504864 NA 0.39 6.85 0.35 3.66e-11 Primary biliary cholangitis; CRC cis rs7666738 0.830 rs4443295 chr4:99044935 G/A cg05340658 chr4:99064831 C4orf37 0.58 8.91 0.44 3.58e-17 Colonoscopy-negative controls vs population controls; CRC cis rs9814567 1.000 rs9869981 chr3:134248801 C/T cg06109529 chr3:134205091 CEP63;ANAPC13 -0.81 -12.19 -0.56 1.92e-28 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC trans rs11098499 0.644 rs10009566 chr4:120558608 A/G cg25214090 chr10:38739885 LOC399744 0.53 8.41 0.42 1.24e-15 Corneal astigmatism; CRC cis rs59698941 0.550 rs11739194 chr5:132201230 T/C cg14825688 chr5:132208181 LEAP2 -0.41 -6.5 -0.34 3.02e-10 Apolipoprotein A-IV levels; CRC cis rs3812762 0.912 rs10769954 chr11:8783713 A/G cg00186954 chr11:8933980 ST5;C11orf17 0.38 6.2 0.32 1.74e-9 Hypospadias; CRC cis rs2730245 0.527 rs2730237 chr7:158706166 A/G cg24397884 chr7:158709396 WDR60 0.77 9.7 0.47 1.02e-19 Height; CRC cis rs3812762 0.833 rs35670750 chr11:8782444 T/C cg00186954 chr11:8933980 ST5;C11orf17 -0.41 -6.52 -0.34 2.68e-10 Hypospadias; CRC cis rs274567 0.501 rs2631368 chr5:131705297 T/G cg11843238 chr5:131593191 PDLIM4 -0.44 -7.72 -0.39 1.41e-13 Blood metabolite levels; CRC cis rs2327429 0.767 rs12190287 chr6:134214525 C/G cg06643013 chr6:134217242 NA -0.43 -7.79 -0.39 8.55e-14 Coronary artery disease; CRC cis rs972578 1.000 rs2038062 chr22:43397966 A/G cg01576275 chr22:43409880 NA -0.49 -7.46 -0.38 7.9e-13 Mean platelet volume; CRC cis rs7113874 0.589 rs10769908 chr11:8484089 A/G cg17679104 chr11:8615758 STK33 0.35 5.83 0.31 1.36e-8 Body mass index in physically active individuals;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs5753618 0.561 rs5753609 chr22:31819212 A/G cg02404636 chr22:31891804 SFI1 0.43 5.8 0.3 1.56e-8 Colorectal cancer; CRC cis rs1348850 0.958 rs11689550 chr2:178456298 A/G cg02961200 chr2:178257176 LOC100130691;AGPS 0.5 7.14 0.37 6.17e-12 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs10751667 0.857 rs7481221 chr11:966813 G/C cg23136738 chr11:925521 AP2A2 -0.42 -7.09 -0.36 8.19e-12 Alzheimer's disease (late onset); CRC cis rs8072100 0.934 rs9905583 chr17:45741016 C/T cg25173405 chr17:45401733 C17orf57 -0.48 -7.44 -0.38 9.08e-13 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs10504229 0.683 rs7816733 chr8:58129855 G/A cg02290350 chr8:58132656 NA -0.58 -8.16 -0.41 7.29e-15 Developmental language disorder (linguistic errors); CRC cis rs7927771 0.864 rs2293577 chr11:47437202 C/T cg20135002 chr11:47629003 NA 0.35 5.75 0.3 2.06e-8 Subjective well-being; CRC cis rs6964587 0.967 rs6974827 chr7:91772945 C/T cg17063962 chr7:91808500 NA 0.84 14.85 0.63 1.52e-38 Breast cancer; CRC cis rs8032158 0.927 rs7179116 chr15:56174827 A/G cg02198044 chr15:56286336 NEDD4 -0.4 -6.32 -0.33 8.27e-10 Keloid; CRC cis rs72781680 0.611 rs2111884 chr2:24289472 A/T cg06627628 chr2:24431161 ITSN2 -0.52 -5.98 -0.31 5.88e-9 Lymphocyte counts; CRC cis rs863345 0.548 rs1032352 chr1:158493154 C/T cg12129480 chr1:158549410 OR10X1 -0.29 -5.95 -0.31 7e-9 Pneumococcal bacteremia; CRC cis rs769267 0.895 rs2916069 chr19:19520358 A/G cg02546618 chr19:19431379 KIAA0892;SF4 0.45 6.31 0.33 9.14e-10 Tonsillectomy; CRC cis rs4919694 0.667 rs75890466 chr10:105076383 C/T cg04362960 chr10:104952993 NT5C2 0.85 7.93 0.4 3.35e-14 Arsenic metabolism; CRC cis rs12630931 1.000 rs11712388 chr3:31975160 C/A cg21375017 chr3:31988082 OSBPL10 0.44 6.14 0.32 2.44e-9 Periodontal disease-related phenotypes; CRC cis rs2204008 0.837 rs7308714 chr12:38274307 T/C cg26384229 chr12:38710491 ALG10B 0.67 9.01 0.44 1.77e-17 Bladder cancer; CRC cis rs870825 0.655 rs28555435 chr4:185647300 C/A cg04058563 chr4:185651563 MLF1IP 0.72 9.3 0.46 2.04e-18 Blood protein levels; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg27054308 chr14:20922865 APEX1;OSGEP 0.54 7.23 0.37 3.34e-12 Thyroid stimulating hormone; CRC cis rs6088590 0.523 rs6058084 chr20:33183804 C/T cg24642439 chr20:33292090 TP53INP2 0.4 6.79 0.35 5.17e-11 Coronary artery disease; CRC cis rs6938 0.618 rs11857695 chr15:75165751 G/T cg14664628 chr15:75095509 CSK -0.65 -10.45 -0.5 2.87e-22 Breast cancer; CRC cis rs10256972 0.706 rs4285396 chr7:1123738 A/G cg09177884 chr7:1199841 ZFAND2A -0.4 -5.75 -0.3 2.01e-8 Longevity;Endometriosis; CRC cis rs1843834 0.539 rs1494109 chr2:225441833 G/A cg22509189 chr2:225307070 NA -0.4 -5.94 -0.31 7.33e-9 IgE levels in asthmatics (D.p. specific); CRC cis rs11723261 0.582 rs6599293 chr4:133027 A/G cg12746427 chr4:53362 ZNF718;ZNF595 0.48 6.49 0.34 3.15e-10 Immune response to smallpox vaccine (IL-6); CRC cis rs798554 0.836 rs2260230 chr7:2822986 T/A cg17321639 chr7:2759063 NA -0.51 -6.77 -0.35 6.01e-11 Height; CRC cis rs35883536 0.566 rs4908086 chr1:101088124 C/T cg14515779 chr1:101123966 NA -0.36 -6.37 -0.33 6.26e-10 Monocyte count; CRC cis rs7918232 0.782 rs7910168 chr10:27465296 G/A cg14442939 chr10:27389572 ANKRD26 0.82 9.11 0.45 8.01e-18 Breast cancer; CRC cis rs1580019 0.587 rs6972365 chr7:32548931 T/A cg06627557 chr7:32535165 LSM5;AVL9 0.97 18.91 0.72 1.7e-54 Cognitive ability; CRC cis rs12760731 0.623 rs10913551 chr1:178410131 T/G cg00404053 chr1:178313656 RASAL2 0.75 9.35 0.46 1.4e-18 Obesity-related traits; CRC trans rs4332037 1.000 rs4332037 chr7:1950809 C/T cg11693508 chr17:37793320 STARD3 0.61 7.54 0.38 4.51e-13 Bipolar disorder; CRC cis rs1707322 1.000 rs34444543 chr1:46358862 G/A cg06784218 chr1:46089804 CCDC17 0.52 8.94 0.44 2.93e-17 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC trans rs11250098 0.600 rs4240671 chr8:10767748 A/G cg06636001 chr8:8085503 FLJ10661 0.5 7.5 0.38 6.02e-13 Morning vs. evening chronotype; CRC cis rs6570726 0.557 rs403956 chr6:145829956 T/C cg13319975 chr6:146136371 FBXO30 -0.62 -9.08 -0.45 1.02e-17 Lobe attachment (rater-scored or self-reported); CRC cis rs66887589 0.592 rs11731571 chr4:120221185 G/A cg09307838 chr4:120376055 NA 0.59 9.04 0.45 1.33e-17 Diastolic blood pressure; CRC cis rs7937682 0.575 rs7124696 chr11:111747297 A/G cg09085632 chr11:111637200 PPP2R1B 0.94 15.75 0.66 4.87e-42 Primary sclerosing cholangitis; CRC cis rs780096 0.565 rs13022659 chr2:27743630 C/T cg24768116 chr2:27665128 KRTCAP3 -0.33 -7.15 -0.37 5.67e-12 Total body bone mineral density; CRC cis rs4563143 0.663 rs73025068 chr19:29238998 G/A cg03161606 chr19:29218774 NA 0.6 7.91 0.4 4.01e-14 Methadone dose in opioid dependence; CRC trans rs2228479 0.850 rs62052711 chr16:89855100 C/A cg24644049 chr4:85504048 CDS1 0.93 7.58 0.39 3.6e-13 Skin colour saturation; CRC cis rs10504229 1.000 rs66886949 chr8:58187613 A/G cg02725872 chr8:58115012 NA -0.38 -6.43 -0.33 4.44e-10 Developmental language disorder (linguistic errors); CRC cis rs2836974 0.568 rs11910906 chr21:40685662 T/C cg06238570 chr21:40685208 BRWD1 -0.87 -13.89 -0.61 7.95e-35 Cognitive function; CRC cis rs6500395 0.962 rs989070 chr16:48602243 G/A cg04672837 chr16:48644449 N4BP1 0.42 5.99 0.31 5.43e-9 Response to tocilizumab in rheumatoid arthritis; CRC trans rs12406019 0.510 rs12126464 chr1:78608215 T/C cg20826526 chr3:156266748 SSR3 -0.4 -6.05 -0.32 3.87e-9 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs13256369 1.000 rs883648 chr8:8569521 A/G cg17143192 chr8:8559678 CLDN23 0.49 6.3 0.33 9.54e-10 Obesity-related traits; CRC cis rs13191362 1.000 rs67747005 chr6:163150845 G/A cg14584255 chr6:163149320 PACRG;PARK2 0.39 6.21 0.32 1.61e-9 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs10911232 0.507 rs3935384 chr1:183028970 C/T ch.1.3577855R chr1:183094577 LAMC1 0.82 14.05 0.61 1.92e-35 Hypertriglyceridemia; CRC cis rs11676348 0.846 rs3890158 chr2:218990292 G/A cg00012203 chr2:219082015 ARPC2 -0.44 -6.45 -0.33 4.11e-10 Ulcerative colitis; CRC cis rs9527 0.590 rs10883830 chr10:104851285 G/A cg15744005 chr10:104629667 AS3MT -0.31 -6.18 -0.32 1.91e-9 Arsenic metabolism; CRC cis rs12477438 0.798 rs1453561 chr2:99613924 C/T cg26064155 chr2:99771622 LIPT1;TSGA10 -0.73 -10.18 -0.49 2.4e-21 Chronic sinus infection; CRC cis rs7927771 0.864 rs4752999 chr11:47428565 C/T cg18512352 chr11:47633146 NA -0.43 -8.32 -0.42 2.44e-15 Subjective well-being; CRC cis rs912057 0.965 rs1294415 chr6:6740633 G/A cg06612196 chr6:6737390 NA 0.55 8.63 0.43 2.67e-16 Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction); CRC cis rs17095355 1.000 rs3862006 chr10:111750764 A/G cg00817464 chr10:111662876 XPNPEP1 0.6 7.89 0.4 4.52e-14 Biliary atresia; CRC cis rs12612619 0.690 rs6754371 chr2:27315064 G/A cg00617064 chr2:27272375 NA -0.37 -5.98 -0.31 5.88e-9 Venous thromboembolism adjusted for sickle cell variant rs77121243-T; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg04586407 chr16:31008574 STX1B 0.43 6.15 0.32 2.21e-9 Response to antipsychotic treatment; CRC cis rs6499255 1.000 rs11644838 chr16:69812705 G/C cg00738113 chr16:70207722 CLEC18C -0.43 -6.12 -0.32 2.62e-9 IgE levels; CRC cis rs826838 0.967 rs11183577 chr12:38781887 A/G cg13010199 chr12:38710504 ALG10B 0.46 6.02 0.31 4.7e-9 Heart rate; CRC cis rs274567 0.501 rs272855 chr5:131687175 C/T cg09877947 chr5:131593287 PDLIM4 0.44 6.9 0.36 2.74e-11 Blood metabolite levels; CRC cis rs12230513 0.732 rs60450959 chr12:55861373 A/T cg19537932 chr12:55886519 OR6C68 -0.73 -9.4 -0.46 9.2e-19 Contrast sensitivity; CRC cis rs8180040 0.845 rs295441 chr3:47333295 T/A cg27129171 chr3:47204927 SETD2 0.57 8.88 0.44 4.4e-17 Colorectal cancer; CRC cis rs2816062 0.813 rs2816050 chr1:18894432 A/G cg18795169 chr1:18902165 NA -0.92 -19.3 -0.73 4.73e-56 Urate levels in lean individuals; CRC cis rs9303401 0.632 rs7502541 chr17:57241019 G/C cg10487724 chr17:56770010 TEX14;RAD51C 0.42 5.92 0.31 7.94e-9 Cognitive test performance; CRC cis rs7811142 1.000 rs7794485 chr7:100068936 T/C cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.16 15.92 0.66 9.96e-43 Platelet count; CRC cis rs4409675 0.597 rs1467464 chr1:28211650 T/C cg11176159 chr1:28213800 NA 0.29 5.6 0.3 4.44e-8 Corneal astigmatism; CRC cis rs12900413 0.687 rs13343248 chr15:90311226 A/T cg24249390 chr15:90295951 MESP1 -0.58 -9.3 -0.46 1.95e-18 Coronary artery aneurysm in Kawasaki disease; CRC cis rs2204008 0.545 rs1663283 chr12:38132039 G/A cg13010199 chr12:38710504 ALG10B -0.41 -5.99 -0.31 5.54e-9 Bladder cancer; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg12849807 chr6:90348187 LYRM2 0.43 6.89 0.36 2.93e-11 Liver disease severity in Alagille syndrome; CRC trans rs7937682 0.889 rs516263 chr11:111484719 A/C cg18187862 chr3:45730750 SACM1L 0.45 6.55 0.34 2.23e-10 Primary sclerosing cholangitis; CRC cis rs9902453 0.933 rs9303628 chr17:28527228 T/C cg26525008 chr17:28256777 EFCAB5;SSH2 0.67 10.85 0.51 1.23e-23 Coffee consumption (cups per day); CRC cis rs10540 0.570 rs8176330 chr11:535798 G/A cg03934478 chr11:495069 RNH1 0.67 7.36 0.38 1.45e-12 Body mass index; CRC cis rs4253772 0.530 rs9615961 chr22:46754993 T/C cg24881330 chr22:46731750 TRMU 0.67 6.12 0.32 2.64e-9 LDL cholesterol;Cholesterol, total; CRC cis rs11098499 0.697 rs10016448 chr4:120298845 A/G cg09307838 chr4:120376055 NA 0.71 10.93 0.52 6.41e-24 Corneal astigmatism; CRC cis rs738322 0.555 rs731821 chr22:38559448 C/A cg03162506 chr22:38580953 NA 0.27 5.76 0.3 1.93e-8 Cutaneous nevi; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg09646206 chr20:17949260 C20orf72;SNX5 0.47 6.55 0.34 2.17e-10 Anxiety disorder; CRC cis rs2516839 0.652 rs2774276 chr1:161011716 G/C cg11161846 chr1:160990452 F11R -0.49 -7.36 -0.38 1.48e-12 Granulocyte percentage of myeloid white cells; CRC cis rs10206020 0.885 rs13388254 chr2:1577209 A/G cg26248373 chr2:1572462 NA -0.83 -12.33 -0.56 5.69e-29 IgG glycosylation; CRC cis rs10992471 0.603 rs13301537 chr9:95229047 A/G cg14631576 chr9:95140430 CENPP -0.41 -7.35 -0.38 1.61e-12 Visceral adipose tissue/subcutaneous adipose tissue ratio; CRC cis rs6496667 1.000 rs8026533 chr15:90893228 A/C cg04176472 chr15:90893244 GABARAPL3 0.53 8.12 0.41 9.57e-15 Rheumatoid arthritis; CRC cis rs34375054 0.573 rs12811438 chr12:125653490 C/T cg06287003 chr12:125626642 AACS -0.6 -6.77 -0.35 5.79e-11 Post bronchodilator FEV1/FVC ratio; CRC cis rs4713118 0.662 rs9393881 chr6:28023751 C/G cg18032046 chr6:28092343 ZSCAN16 -0.46 -5.67 -0.3 3.18e-8 Parkinson's disease; CRC cis rs561341 0.714 rs473535 chr17:30312365 A/G cg19193384 chr17:30244184 NA -0.64 -7.44 -0.38 8.6e-13 Hip circumference adjusted for BMI; CRC cis rs4804416 1.000 rs4804414 chr19:7223785 C/T cg00428638 chr19:7224713 INSR 0.59 9.71 0.47 8.9e-20 Thyroid hormone levels;Hypothyroidism; CRC cis rs7552404 0.691 rs61770550 chr1:76366966 C/T cg10523679 chr1:76189770 ACADM 0.73 8.73 0.43 1.3e-16 Blood metabolite levels;Acylcarnitine levels; CRC cis rs6504622 0.557 rs7213526 chr17:45011157 T/C cg16759221 chr17:45003025 GOSR2 0.58 9.41 0.46 9.07e-19 Orofacial clefts; CRC cis rs853679 0.513 rs13437444 chr6:28070998 C/T cg12273811 chr6:28175739 NA 0.64 6.54 0.34 2.41e-10 Depression; CRC cis rs3785574 0.962 rs2584628 chr17:61894578 T/C cg06873352 chr17:61820015 STRADA 0.51 8.13 0.41 8.54e-15 Height; CRC cis rs713477 0.654 rs4901569 chr14:55912880 C/T cg13175173 chr14:55914753 NA -0.44 -7.75 -0.39 1.13e-13 Pediatric bone mineral content (femoral neck); CRC cis rs7677751 0.806 rs7679903 chr4:55097373 T/C cg13615338 chr4:55094005 PDGFRA 0.4 5.8 0.3 1.57e-8 Corneal astigmatism; CRC cis rs1552244 0.810 rs35711405 chr3:10116939 C/T cg10729496 chr3:10149963 C3orf24 0.55 7.26 0.37 2.73e-12 Alzheimer's disease; CRC cis rs12597458 0.763 rs7195958 chr16:72036577 A/G cg23815491 chr16:72088622 HP -0.5 -7.92 -0.4 3.77e-14 Prostate cancer; CRC trans rs12599106 0.754 rs11640596 chr16:34347277 T/C cg01516881 chr6:292596 DUSP22 -0.55 -7.88 -0.4 4.8e-14 Menopause (age at onset); CRC cis rs1862618 0.853 rs252898 chr5:56188931 T/C cg12311346 chr5:56204834 C5orf35 -0.83 -10.44 -0.5 3.04e-22 Initial pursuit acceleration; CRC cis rs7927771 0.524 rs7107792 chr11:47669249 A/C cg20307385 chr11:47447363 PSMC3 0.47 6.92 0.36 2.34e-11 Subjective well-being; CRC cis rs344364 0.511 rs2982446 chr16:1947153 C/T cg09830162 chr16:1889614 FAHD1;C16orf73 -0.76 -9.14 -0.45 6.71e-18 Glomerular filtration rate in chronic kidney disease; CRC cis rs3858526 0.628 rs1840177 chr11:5944627 T/G cg05234568 chr11:5960015 NA 0.67 10.82 0.51 1.5e-23 DNA methylation (variation); CRC cis rs2882667 0.690 rs10043478 chr5:138188711 C/G cg09476006 chr5:138032270 NA 0.54 9.36 0.46 1.28e-18 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs9393692 0.557 rs62394764 chr6:26305503 T/C cg00631329 chr6:26305371 NA -0.53 -8.8 -0.44 8.16e-17 Educational attainment; CRC cis rs12545109 0.876 rs1992120 chr8:57337112 G/A cg09654669 chr8:57350985 NA -0.45 -6.01 -0.31 5.02e-9 Obesity-related traits; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg06442790 chr1:89458396 RBMXL1;CCBL2 0.41 6.43 0.33 4.46e-10 Liver disease severity in Alagille syndrome; CRC cis rs501120 0.657 rs114070077 chr10:44742911 A/G cg09554077 chr10:44749378 NA 0.83 10.78 0.51 2.11e-23 Coronary artery disease;Coronary heart disease; CRC cis rs7666738 0.830 rs9998582 chr4:98938949 T/C cg05340658 chr4:99064831 C4orf37 0.6 9.35 0.46 1.41e-18 Colonoscopy-negative controls vs population controls; CRC cis rs17401966 0.838 rs61775887 chr1:10284733 T/C cg19773385 chr1:10388646 KIF1B -0.63 -9.71 -0.47 8.91e-20 Hepatocellular carcinoma; CRC cis rs2281845 0.533 rs112365857 chr1:201097222 G/C cg22815214 chr1:201083145 CACNA1S 0.54 6.74 0.35 6.9e-11 Permanent tooth development; CRC cis rs4363385 0.782 rs394859 chr1:153025704 T/C cg25856811 chr1:152973957 SPRR3 -0.27 -7.5 -0.38 5.87e-13 Inflammatory skin disease; CRC cis rs4474465 1.000 rs7935292 chr11:78169885 C/G cg27205649 chr11:78285834 NARS2 -0.48 -5.94 -0.31 7.15e-9 Alzheimer's disease (survival time); CRC cis rs853679 0.517 rs9380047 chr6:28037893 G/T cg06470822 chr6:28175283 NA 0.98 13.08 0.59 8.77e-32 Depression; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg15428304 chr15:63481580 RAB8B 0.42 6.4 0.33 5.23e-10 Intelligence (multi-trait analysis); CRC cis rs7605827 0.930 rs10929374 chr2:15676884 T/A cg19274914 chr2:15703543 NA 0.37 5.61 0.3 4.2e-8 Educational attainment (years of education); CRC cis rs875971 1.000 rs9986696 chr7:65704576 C/A cg18912574 chr7:65842487 NCRNA00174 -0.38 -6.5 -0.34 3e-10 Aortic root size; CRC cis rs738322 0.726 rs5750561 chr22:38595260 A/T cg25457927 chr22:38595422 NA 0.53 11.8 0.55 4.99e-27 Cutaneous nevi; CRC cis rs1862618 0.641 rs252893 chr5:56224714 T/C cg18230493 chr5:56204884 C5orf35 -0.59 -8.66 -0.43 2.09e-16 Initial pursuit acceleration; CRC cis rs763014 0.966 rs4984677 chr16:671682 A/G cg00908189 chr16:619842 PIGQ 0.68 11.18 0.52 8.4e-25 Height; CRC cis rs6502050 0.835 rs11077971 chr17:80090629 A/G cg02741985 chr17:80059408 CCDC57 0.43 7.16 0.37 5.22e-12 Life satisfaction; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg14509921 chr1:184357113 C1orf21 0.46 6.01 0.31 4.93e-9 Thyroid stimulating hormone; CRC trans rs4785204 1.000 rs8064107 chr16:50094323 T/C cg07960154 chr17:37760198 NEUROD2 -0.66 -6.13 -0.32 2.52e-9 Esophageal cancer (squamous cell); CRC cis rs7927771 0.793 rs12803525 chr11:47413475 G/A cg05585544 chr11:47624801 NA -0.55 -9.73 -0.47 8.12e-20 Subjective well-being; CRC cis rs225245 0.531 rs321609 chr17:33880676 G/T cg05299278 chr17:33885742 SLFN14 0.41 5.76 0.3 1.91e-8 Reticulocyte count;Reticulocyte fraction of red cells;High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells; CRC trans rs1005277 0.579 rs2504140 chr10:38387579 T/G cg17830980 chr10:43048298 ZNF37B -0.6 -9.96 -0.48 1.3e-20 Extrinsic epigenetic age acceleration; CRC cis rs4073416 0.542 rs7144345 chr14:66111841 G/C cg03016385 chr14:66212404 NA -0.45 -6.2 -0.32 1.67e-9 N-glycan levels; CRC cis rs9486719 0.857 rs4265039 chr6:96878929 T/C cg06623918 chr6:96969491 KIAA0776 0.85 12.67 0.57 3.16e-30 Migraine;Coronary artery disease; CRC cis rs4629180 0.675 rs6742474 chr2:102091075 G/A cg04415270 chr2:102091202 RFX8 -0.35 -5.95 -0.31 6.79e-9 Chronic rhinosinusitis with nasal polyps; CRC cis rs3743266 0.507 rs34092508 chr15:60722979 C/T cg21667061 chr15:60772094 NARG2 0.37 5.64 0.3 3.68e-8 Menarche (age at onset); CRC cis rs875971 0.862 rs1695820 chr7:65844563 G/A cg18252515 chr7:66147081 NA -0.41 -5.94 -0.31 7.15e-9 Aortic root size; CRC cis rs17001868 0.568 rs9611312 chr22:40734790 T/C cg07138101 chr22:40742427 ADSL 0.59 7.84 0.4 6.24e-14 Mammographic density (dense area); CRC cis rs11622475 1.000 rs1187448 chr14:104406627 C/T cg20488157 chr14:104394430 TDRD9 0.64 9.54 0.47 3.44e-19 Bipolar disorder; CRC cis rs6938 0.534 rs12904897 chr15:75217686 A/G cg21523564 chr15:75251491 NA 0.37 5.66 0.3 3.22e-8 Breast cancer; CRC cis rs1580019 0.961 rs1580021 chr7:32497702 T/G cg06627557 chr7:32535165 LSM5;AVL9 0.71 11.2 0.53 6.71e-25 Cognitive ability; CRC cis rs514406 0.621 rs2003250 chr1:53196666 T/C cg27535305 chr1:53392650 SCP2 0.36 6.42 0.33 4.77e-10 Monocyte count; CRC cis rs763121 0.853 rs5750671 chr22:39094619 A/C cg06544989 chr22:39130855 UNC84B 0.49 7.78 0.39 9.51e-14 Menopause (age at onset); CRC cis rs501120 0.584 rs11511598 chr10:44716036 C/T cg09554077 chr10:44749378 NA 0.65 7.29 0.37 2.37e-12 Coronary artery disease;Coronary heart disease; CRC cis rs7119 0.717 rs11636529 chr15:77816220 T/C cg10437265 chr15:77819839 NA 0.69 12.74 0.57 1.76e-30 Type 2 diabetes; CRC cis rs2282802 0.635 rs270162 chr5:139539090 A/G cg26211634 chr5:139558579 C5orf32 -0.37 -6.38 -0.33 6e-10 Intelligence (multi-trait analysis); CRC cis rs972578 1.000 rs738378 chr22:43398962 A/G cg01576275 chr22:43409880 NA 0.47 7.32 0.37 1.9e-12 Mean platelet volume; CRC cis rs3540 0.533 rs937793 chr15:91053583 A/G cg22089800 chr15:90895588 ZNF774 -0.61 -10.23 -0.49 1.66e-21 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; CRC cis rs1005277 0.579 rs2504140 chr10:38387579 T/G cg25427524 chr10:38739819 LOC399744 -0.77 -13.64 -0.6 6.85e-34 Extrinsic epigenetic age acceleration; CRC cis rs2239547 0.522 rs6771610 chr3:53026104 T/C cg11645453 chr3:52864694 ITIH4 0.54 9.39 0.46 1.01e-18 Schizophrenia; CRC cis rs2976388 0.578 rs3758081 chr8:143824373 A/G cg10596483 chr8:143751796 JRK -0.49 -6.68 -0.35 9.98e-11 Urinary tract infection frequency; CRC cis rs651907 0.557 rs13069443 chr3:101373305 C/T cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.62 8.41 0.42 1.3e-15 Colorectal cancer; CRC cis rs1005277 0.579 rs2474587 chr10:38420666 C/T cg25427524 chr10:38739819 LOC399744 -0.75 -13.3 -0.59 1.39e-32 Extrinsic epigenetic age acceleration; CRC cis rs2624839 0.704 rs1046956 chr3:50222926 T/A cg24110177 chr3:50126178 RBM5 0.42 5.78 0.3 1.7e-8 Intelligence (multi-trait analysis); CRC cis rs9916302 0.768 rs11078900 chr17:37614641 C/T cg07936489 chr17:37558343 FBXL20 -0.79 -11.81 -0.55 4.59e-27 Glomerular filtration rate (creatinine); CRC cis rs694739 1.000 rs499425 chr11:64105929 A/G cg02228329 chr11:64053129 BAD;GPR137 -0.6 -8.86 -0.44 4.97e-17 Alopecia areata;Crohn's disease;Psoriasis vulgaris; CRC cis rs2732480 0.577 rs2634693 chr12:48706498 C/T cg24011408 chr12:48396354 COL2A1 0.46 6.28 0.33 1.1e-9 Hemoglobin concentration;Red blood cell count;Hematocrit; CRC cis rs11098499 0.780 rs7692994 chr4:120427489 C/A cg24375607 chr4:120327624 NA 0.46 6.99 0.36 1.52e-11 Corneal astigmatism; CRC cis rs10504229 0.593 rs116916898 chr8:57984958 G/A cg21724239 chr8:58056113 NA 0.79 8.62 0.43 2.91e-16 Developmental language disorder (linguistic errors); CRC trans rs58106596 0.950 rs11695646 chr2:232584807 C/T cg01370599 chr3:116745421 NA -0.46 -6.33 -0.33 8.15e-10 White blood cell count;Lymphocyte counts; CRC cis rs3617 0.625 rs56019197 chr3:52874753 T/C cg11645453 chr3:52864694 ITIH4 -0.46 -9.23 -0.45 3.41e-18 Red blood cell count;Autism spectrum disorder or schizophrenia; CRC cis rs765787 0.530 rs4775819 chr15:45525966 C/T cg24006582 chr15:45444508 DUOX1 -0.56 -8.46 -0.42 8.63e-16 Uric acid levels; CRC cis rs1577917 1.000 rs1337850 chr6:86729103 G/A cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.52 -6.53 -0.34 2.57e-10 Response to antipsychotic treatment; CRC cis rs1552244 1.000 rs17032268 chr3:10067972 C/T cg18598329 chr3:10140678 FANCD2;C3orf24 -0.88 -12.22 -0.56 1.48e-28 Alzheimer's disease; CRC cis rs8067545 0.611 rs1992561 chr17:20219119 G/A cg13482628 chr17:19912719 NA -0.48 -7.37 -0.38 1.4e-12 Schizophrenia; CRC cis rs7811142 0.562 rs7786844 chr7:99934008 T/G cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.11 16.47 0.67 6.96e-45 Platelet count; CRC cis rs853679 0.567 rs6905380 chr6:28374902 A/G cg21251018 chr6:28226885 NKAPL 0.42 6.08 0.32 3.25e-9 Depression; CRC trans rs629535 0.767 rs72654073 chr8:70081231 G/A cg21567404 chr3:27674614 NA -0.93 -14.86 -0.63 1.48e-38 Dupuytren's disease; CRC cis rs12291225 0.585 rs34171876 chr11:14353957 G/C cg19336497 chr11:14380999 RRAS2 -0.52 -8.96 -0.44 2.5e-17 Sense of smell; CRC cis rs9443645 0.901 rs9359354 chr6:79590385 A/G cg09184832 chr6:79620586 NA -0.52 -9.73 -0.47 7.62e-20 Intelligence (multi-trait analysis); CRC cis rs6951245 0.572 rs79489623 chr7:1045632 C/T cg21664854 chr7:1097933 C7orf50;GPR146 0.77 5.99 0.31 5.63e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC trans rs7647973 0.554 rs13096480 chr3:49658084 A/G cg21665057 chr3:196295764 WDR53;FBXO45 -0.67 -7.37 -0.38 1.43e-12 Menarche (age at onset); CRC cis rs910316 1.000 rs11623413 chr14:75588824 C/T cg08847533 chr14:75593920 NEK9 -0.93 -17.8 -0.7 4.12e-50 Height; CRC cis rs4268898 0.636 rs72787383 chr2:24583861 G/A cg06627628 chr2:24431161 ITSN2 -0.82 -11.03 -0.52 2.81e-24 Asthma; CRC cis rs10489202 0.513 rs4657731 chr1:168081255 C/T cg24449463 chr1:168025552 DCAF6 -0.51 -7.15 -0.37 5.61e-12 Schizophrenia; CRC cis rs360798 0.512 rs7562149 chr2:63008414 A/G cg17519650 chr2:63277830 OTX1 -0.42 -5.98 -0.31 5.91e-9 Coronary artery disease; CRC cis rs9747201 1.000 rs12451470 chr17:80177532 G/A cg09264619 chr17:80180166 NA -0.5 -7.08 -0.36 8.53e-12 Peripheral arterial disease (traffic-related air pollution interaction); CRC trans rs6951245 0.935 rs76525951 chr7:1096013 C/T cg13565492 chr6:43139072 SRF -0.71 -7.38 -0.38 1.32e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg00910907 chr19:4124188 MAP2K2 0.44 5.97 0.31 6.09e-9 Anxiety disorder; CRC cis rs2710642 0.821 rs2710639 chr2:63138963 C/T cg17519650 chr2:63277830 OTX1 0.45 6.21 0.32 1.59e-9 LDL cholesterol levels;LDL cholesterol; CRC cis rs514406 0.505 rs269287 chr1:53168842 T/C cg08859206 chr1:53392774 SCP2 -0.39 -6.05 -0.32 3.83e-9 Monocyte count; CRC cis rs3996993 0.809 rs12529579 chr6:52686079 T/C cg20803780 chr6:52668592 GSTA1 0.35 6.32 0.33 8.38e-10 Hemoglobin concentration; CRC cis rs775227 1.000 rs41271355 chr3:113004155 G/A cg18753928 chr3:113234510 CCDC52 -0.49 -6.16 -0.32 2.09e-9 Dental caries; CRC cis rs477895 0.653 rs11602181 chr11:63896591 C/G cg23719950 chr11:63933701 MACROD1 -0.65 -8.41 -0.42 1.24e-15 Mean platelet volume; CRC cis rs853679 0.546 rs483143 chr6:27846744 G/C cg06470822 chr6:28175283 NA 0.69 5.82 0.31 1.37e-8 Depression; CRC cis rs1267303 0.682 rs1886117 chr1:46964909 T/A cg08533674 chr1:46993347 NA 0.43 6.13 0.32 2.53e-9 Monobrow; CRC cis rs311392 0.967 rs4463399 chr8:55089449 T/C cg06042504 chr8:55087323 NA -0.44 -6.82 -0.35 4.35e-11 Pelvic organ prolapse (moderate/severe); CRC cis rs4665630 0.522 rs114880940 chr2:23930352 G/A cg08063864 chr2:24346004 PFN4;LOC375190 0.95 7.28 0.37 2.44e-12 Hypertension; CRC cis rs1799949 1.000 rs11658754 chr17:41292739 G/A cg19454999 chr17:41278357 BRCA1;NBR2 0.55 8.65 0.43 2.28e-16 Menopause (age at onset); CRC trans rs9329221 0.509 rs3088186 chr8:10226355 C/T cg06636001 chr8:8085503 FLJ10661 0.49 6.72 0.35 7.9e-11 Neuroticism; CRC cis rs7208859 0.623 rs9893422 chr17:29111715 A/G cg13385521 chr17:29058706 SUZ12P 0.73 8.4 0.42 1.39e-15 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs7811142 1.000 rs6979335 chr7:100089860 T/C cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.72 9.46 0.46 6.3e-19 Platelet count; CRC cis rs78545713 0.536 rs78653353 chr6:26208917 A/G cg01420254 chr6:26195488 NA 0.69 6.13 0.32 2.45e-9 Iron status biomarkers (total iron binding capacity); CRC cis rs11764590 0.724 rs55789728 chr7:2107649 A/G cg14004847 chr7:1930337 MAD1L1 -0.46 -5.91 -0.31 8.45e-9 Neuroticism; CRC cis rs9894429 0.621 rs9747119 chr17:79607017 A/G cg18240062 chr17:79603768 NPLOC4 0.47 7.35 0.38 1.59e-12 Eye color traits; CRC cis rs3924048 0.559 rs6541038 chr1:12626210 G/T cg00291366 chr1:12616550 NA 0.53 9.53 0.47 3.57e-19 Optic cup area; CRC cis rs12477438 0.765 rs6737257 chr2:99683330 G/A cg14399236 chr2:99771627 LIPT1;TSGA10 -0.6 -8.19 -0.41 6.03e-15 Chronic sinus infection; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg08826281 chr19:49655176 HRC 0.44 7.14 0.37 6.05e-12 Liver disease severity in Alagille syndrome; CRC trans rs6469488 1.000 rs2063497 chr8:114900979 A/G cg16821992 chr8:116679935 TRPS1 -0.48 -6.01 -0.31 4.96e-9 Bronchodilator response in asthma (inhaled corticosteroid treatment interaction); CRC cis rs28386778 0.897 rs9913323 chr17:61851485 C/A cg25654072 chr17:61904446 PSMC5;FTSJ3 0.71 11.06 0.52 2.21e-24 Prudent dietary pattern; CRC cis rs883565 0.569 rs784515 chr3:39163848 C/T cg01426195 chr3:39028469 NA 0.42 6.97 0.36 1.69e-11 Handedness; CRC cis rs1862618 0.853 rs33322 chr5:56175226 A/G cg12311346 chr5:56204834 C5orf35 -0.79 -10.04 -0.48 7.48e-21 Initial pursuit acceleration; CRC cis rs12913538 0.862 rs4774441 chr15:62887791 C/T cg09983546 chr15:62884068 NA 0.55 8.67 0.43 2.03e-16 Sleep depth; CRC cis rs1267303 0.642 rs7542296 chr1:46998009 A/G cg25110126 chr1:46999211 NA 0.57 9.11 0.45 8.45e-18 Monobrow; CRC cis rs939584 1.000 rs1320338 chr2:649347 T/G cg03610516 chr2:642275 NA -0.42 -5.85 -0.31 1.2e-8 Body mass index; CRC cis rs36093844 0.851 rs10898417 chr11:85547503 C/T cg25872744 chr11:85566296 CCDC83 0.38 5.8 0.3 1.55e-8 IgG response to Plasmodium falciparum antigens (GLURP, MSP2 FC27, MSP2 3D7); CRC cis rs995000 0.868 rs10889360 chr1:63173918 C/T cg19896129 chr1:63156450 NA 0.38 5.62 0.3 4.17e-8 Triglyceride levels; CRC cis rs7666738 0.830 rs1365458 chr4:98950961 C/T cg05340658 chr4:99064831 C4orf37 0.63 10.07 0.49 5.81e-21 Colonoscopy-negative controls vs population controls; CRC cis rs7671266 0.559 rs7681212 chr4:10358964 C/G cg00071950 chr4:10020882 SLC2A9 0.46 6.19 0.32 1.84e-9 Cardiovascular disease risk factors; CRC trans rs2303319 0.504 rs62189043 chr2:162608466 A/T cg22988483 chr14:93581567 ITPK1 -0.66 -6.07 -0.32 3.52e-9 Cognitive function; CRC cis rs7666738 0.830 rs13149404 chr4:99070236 A/G cg05340658 chr4:99064831 C4orf37 0.6 9.32 0.46 1.72e-18 Colonoscopy-negative controls vs population controls; CRC trans rs1669338 1.000 rs1669338 chr3:3199635 A/C cg13491731 chr14:76594783 NA -0.43 -6.51 -0.34 2.87e-10 White matter integrity; CRC cis rs898097 0.585 rs9892342 chr17:80893029 C/T cg10494973 chr17:80897199 TBCD -0.38 -5.99 -0.31 5.45e-9 Breast cancer; CRC cis rs9660992 0.573 rs4400674 chr1:205218425 A/C cg00857998 chr1:205179979 DSTYK -0.45 -5.94 -0.31 7.38e-9 Mean corpuscular volume;Mean platelet volume; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg12334424 chr7:100034074 C7orf47 0.38 6.17 0.32 2.01e-9 Liver disease severity in Alagille syndrome; CRC trans rs6494488 0.500 rs16948170 chr15:64967654 C/T cg07470598 chr14:107239068 NA 0.52 6.21 0.32 1.56e-9 Coronary artery disease; CRC cis rs832540 0.966 rs252923 chr5:56205662 T/G cg20203395 chr5:56204925 C5orf35 -0.43 -6.1 -0.32 2.91e-9 Coronary artery disease; CRC cis rs6952808 1.000 rs12540579 chr7:1882227 C/A cg00106254 chr7:1943704 MAD1L1 -0.42 -6.17 -0.32 2.02e-9 Bipolar disorder and schizophrenia; CRC cis rs35110281 0.659 rs11702544 chr21:45091861 C/T cg01579765 chr21:45077557 HSF2BP -0.35 -6.68 -0.35 1.03e-10 Mean corpuscular volume; CRC cis rs17125944 0.505 rs77137752 chr14:53230496 G/T cg00686598 chr14:53173677 PSMC6 1.17 10.88 0.51 9.5e-24 Alzheimer's disease (late onset); CRC cis rs6831352 0.819 rs13832 chr4:99993075 C/A cg12011299 chr4:100065546 ADH4 0.47 9.53 0.47 3.67e-19 Alcohol dependence; CRC cis rs11212617 1.000 rs186595 chr11:108251211 C/A cg14761454 chr11:108092087 ATM;NPAT 0.44 6.77 0.35 5.98e-11 Response to metformin in type 2 diabetes (glycemic); CRC cis rs6952808 0.656 rs11764212 chr7:2067593 C/A cg00106254 chr7:1943704 MAD1L1 -0.5 -7.05 -0.36 1.07e-11 Bipolar disorder and schizophrenia; CRC cis rs10504229 0.635 rs72649130 chr8:58053810 G/T cg21724239 chr8:58056113 NA 0.79 9.65 0.47 1.4e-19 Developmental language disorder (linguistic errors); CRC cis rs6951245 1.000 rs77702926 chr7:1088838 G/A cg26224354 chr7:1096374 C7orf50;GPR146 -0.94 -11.87 -0.55 2.79e-27 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs524281 0.773 rs2298468 chr11:66042962 G/A cg14036092 chr11:66035641 RAB1B -0.55 -6.04 -0.32 4.16e-9 Electroencephalogram traits; CRC cis rs7085104 0.572 rs284856 chr10:104574329 A/T cg23093090 chr10:104574429 C10orf26 0.4 6.65 0.34 1.25e-10 Immature fraction of reticulocytes;Schizophrenia; CRC trans rs459571 1.000 rs459571 chr9:136912626 C/T cg09836344 chr4:1243392 C4orf42;CTBP1 -0.84 -11.54 -0.54 4.39e-26 Platelet distribution width; CRC cis rs2842992 0.872 rs9456440 chr6:160074463 G/T cg19482086 chr6:160211437 TCP1;MRPL18 0.68 8.45 0.42 9.44e-16 Age-related macular degeneration (geographic atrophy); CRC cis rs514406 0.683 rs6588440 chr1:53209587 C/T cg27535305 chr1:53392650 SCP2 0.36 6.48 0.34 3.27e-10 Monocyte count; CRC cis rs10911363 0.592 rs2702180 chr1:183517971 T/C cg09173681 chr1:183549694 NCF2 0.76 10.93 0.52 6.24e-24 Systemic lupus erythematosus; CRC cis rs6815814 0.768 rs2013740 chr4:38891737 A/G cg06935464 chr4:38784597 TLR10 0.59 7.08 0.36 8.58e-12 Breast cancer; CRC cis rs12887734 0.546 rs4906376 chr14:104272165 A/C cg08213375 chr14:104286397 PPP1R13B 0.54 8.28 0.42 3.24e-15 Schizophrenia;Autism spectrum disorder or schizophrenia; CRC cis rs1065852 0.526 rs2097561 chr22:42389431 T/C cg00645731 chr22:42541494 CYP2D7P1 0.4 6.86 0.35 3.42e-11 Response to serotonin reuptake inhibitors in major depressive disorder (plasma drug and metabolite levels); CRC cis rs3820068 0.705 rs2145396 chr1:15875184 A/G cg27534772 chr1:16042836 PLEKHM2 0.42 6.93 0.36 2.27e-11 Systolic blood pressure; CRC trans rs10982213 0.830 rs2274163 chr9:117188714 C/T cg13884470 chr9:86595151 HNRNPK;RMI1 0.36 6.04 0.32 4.22e-9 Interleukin-6 levels; CRC cis rs365302 1.000 rs444708 chr6:159644830 C/T cg14500486 chr6:159655392 FNDC1 0.43 6.59 0.34 1.77e-10 Coronary heart disease; CRC cis rs449789 0.681 rs12529478 chr6:159704722 T/C cg14500486 chr6:159655392 FNDC1 -0.48 -7.4 -0.38 1.13e-12 Pulse pressure; CRC cis rs9733 0.519 rs1336899 chr1:150678910 T/C cg18016565 chr1:150552671 MCL1 0.46 6.62 0.34 1.45e-10 Tonsillectomy; CRC cis rs10504229 1.000 rs67630725 chr8:58185580 G/A cg05313129 chr8:58192883 C8orf71 -0.47 -6.99 -0.36 1.49e-11 Developmental language disorder (linguistic errors); CRC cis rs12135062 0.851 rs2651925 chr1:3101863 C/G cg21609526 chr1:3105151 PRDM16 0.52 8.8 0.44 7.74e-17 Migraine; CRC cis rs9733 0.526 rs11204698 chr1:150659545 G/A cg10589385 chr1:150898437 SETDB1 0.29 6.2 0.32 1.7e-9 Tonsillectomy; CRC cis rs4076764 0.958 rs6688997 chr1:163411562 G/A cg06092702 chr1:163392909 NA -0.61 -9.56 -0.47 2.83e-19 Motion sickness; CRC cis rs12291225 0.535 rs10832248 chr11:14413087 G/A cg19336497 chr11:14380999 RRAS2 -0.48 -8.29 -0.42 2.83e-15 Sense of smell; CRC trans rs7819412 0.807 rs4840542 chr8:10944809 G/T cg16141378 chr3:129829833 LOC729375 0.42 6.11 0.32 2.81e-9 Triglycerides; CRC cis rs2404602 0.716 rs8025134 chr15:76781729 C/T cg23625390 chr15:77176239 SCAPER 0.51 7.47 0.38 7.42e-13 Blood metabolite levels; CRC cis rs10504229 1.000 rs77857677 chr8:58170131 G/A cg02725872 chr8:58115012 NA -0.38 -6.43 -0.33 4.44e-10 Developmental language disorder (linguistic errors); CRC trans rs875971 0.545 rs4718335 chr7:65804606 C/T cg02869306 chr7:64672164 INTS4L1 -0.44 -6.45 -0.34 3.9e-10 Aortic root size; CRC cis rs1862618 0.853 rs43184 chr5:56141777 G/C cg20203395 chr5:56204925 C5orf35 -0.72 -8.56 -0.43 4.54e-16 Initial pursuit acceleration; CRC trans rs1997103 0.954 rs9649780 chr7:55411741 A/C cg20935933 chr6:143382018 AIG1 0.51 6.63 0.34 1.35e-10 QRS interval (sulfonylurea treatment interaction); CRC cis rs447735 0.565 rs10852626 chr16:89914633 T/G cg03605463 chr16:89740564 NA -0.4 -5.69 -0.3 2.85e-8 Hemoglobin concentration; CRC cis rs2742417 1.000 rs2742368 chr3:45752293 C/A cg04837898 chr3:45731254 SACM1L -0.36 -5.92 -0.31 7.95e-9 Response to anti-depressant treatment in major depressive disorder; CRC cis rs11098499 0.863 rs3736115 chr4:120488703 A/G cg09307838 chr4:120376055 NA -0.67 -10.06 -0.48 6.42e-21 Corneal astigmatism; CRC trans rs73162807 0.793 rs6802762 chr3:146443921 T/C cg26896787 chr1:228603707 TRIM17 -0.59 -5.99 -0.31 5.61e-9 Platelet-derived growth factor BB levels; CRC cis rs9916302 0.706 rs4795375 chr17:37662932 T/C cg15445000 chr17:37608096 MED1 0.36 6.28 0.33 1.08e-9 Glomerular filtration rate (creatinine); CRC cis rs28386778 0.966 rs2854206 chr17:61947203 G/A cg25654072 chr17:61904446 PSMC5;FTSJ3 0.71 11.01 0.52 3.17e-24 Prudent dietary pattern; CRC trans rs7690467 0.720 rs13111735 chr4:133395764 C/A cg19296258 chr17:78878799 RPTOR -0.47 -6.3 -0.33 9.32e-10 Eating disorders; CRC cis rs4713675 0.505 rs753890 chr6:33652880 G/A cg14003231 chr6:33640908 ITPR3 0.53 8.52 0.43 5.81e-16 Plateletcrit; CRC cis rs977987 0.931 rs1424013 chr16:75495986 T/C cg03315344 chr16:75512273 CHST6 0.6 10.17 0.49 2.69e-21 Dupuytren's disease; CRC cis rs853679 0.517 rs9393884 chr6:28046789 A/G cg23161317 chr6:28129485 ZNF389 0.52 6.47 0.34 3.66e-10 Depression; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg22029345 chr4:6711623 MRFAP1L1 0.44 6.37 0.33 6.22e-10 Anxiety disorder; CRC trans rs941408 0.515 rs4624312 chr19:2774460 T/C cg22153745 chr1:153894579 GATAD2B -0.56 -7.33 -0.37 1.77e-12 Total cholesterol levels; CRC cis rs11645898 0.935 rs11640722 chr16:72172300 C/T cg14768367 chr16:72042858 DHODH -0.6 -6.7 -0.35 8.97e-11 Blood protein levels; CRC cis rs58688157 0.705 rs12795572 chr11:590999 G/A cg07212818 chr11:638076 DRD4 -0.46 -5.93 -0.31 7.71e-9 Systemic lupus erythematosus; CRC trans rs7395662 0.591 rs10838968 chr11:48595046 A/G cg15704280 chr7:45808275 SEPT13 -0.49 -6.9 -0.36 2.71e-11 HDL cholesterol; CRC cis rs7635838 0.617 rs346084 chr3:11281159 C/T cg00170343 chr3:11313890 ATG7 0.57 8.9 0.44 3.76e-17 HDL cholesterol; CRC cis rs10256972 0.552 rs2960831 chr7:1201192 A/T cg26608667 chr7:1196370 ZFAND2A 0.42 6.85 0.35 3.54e-11 Longevity;Endometriosis; CRC cis rs12586317 0.586 rs74243590 chr14:35513246 G/A cg05294307 chr14:35346193 BAZ1A -0.71 -7.63 -0.39 2.62e-13 Psoriasis; CRC trans rs7267979 0.966 rs2500433 chr20:25296335 A/G cg17903999 chr18:56338584 MALT1 0.43 6.86 0.35 3.43e-11 Liver enzyme levels (alkaline phosphatase); CRC cis rs9611519 0.780 rs2284079 chr22:41658632 C/T cg06634786 chr22:41940651 POLR3H -0.45 -6.11 -0.32 2.84e-9 Neuroticism; CRC cis rs977987 0.836 rs11646044 chr16:75312548 G/T cg03315344 chr16:75512273 CHST6 0.53 8.81 0.44 7.31e-17 Dupuytren's disease; CRC cis rs2739330 0.731 rs2000468 chr22:24241611 G/T cg09033563 chr22:24373618 LOC391322 -0.42 -5.99 -0.31 5.37e-9 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs10924970 0.967 rs10754588 chr1:235438205 C/T cg26050004 chr1:235667680 B3GALNT2 0.4 6.01 0.31 4.84e-9 Asthma; CRC cis rs6032067 0.929 rs6032044 chr20:43819416 C/A cg10761708 chr20:43804764 PI3 0.5 5.65 0.3 3.49e-8 Blood protein levels; CRC cis rs17376456 0.825 rs17314825 chr5:93234937 A/G cg25358565 chr5:93447407 FAM172A 0.99 10.35 0.5 6.39e-22 Diabetic retinopathy; CRC cis rs4285028 0.948 rs73855480 chr3:121676646 A/G cg11130432 chr3:121712080 ILDR1 -0.52 -6.75 -0.35 6.81e-11 Multiple sclerosis; CRC cis rs9942416 0.601 rs40059 chr5:74964582 A/G cg00601450 chr5:74908170 NA -0.41 -6.03 -0.32 4.31e-9 Age-related disease endophenotypes; CRC cis rs2180341 0.883 rs7760748 chr6:127690062 C/T cg24812749 chr6:127587940 RNF146 0.92 13.17 0.59 4.28e-32 Breast cancer; CRC trans rs9858542 0.953 rs9862080 chr3:49674458 A/G cg21665057 chr3:196295764 WDR53;FBXO45 -0.71 -9.36 -0.46 1.27e-18 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs7618501 1.000 rs11130219 chr3:49752427 C/T cg24308560 chr3:49941425 MST1R 0.45 7.16 0.37 5.47e-12 Intelligence (multi-trait analysis); CRC cis rs4731207 0.596 rs10270055 chr7:124649406 T/G cg23710748 chr7:124431027 NA -0.39 -6.25 -0.33 1.27e-9 Cutaneous malignant melanoma; CRC cis rs10256972 0.521 rs7811577 chr7:1102829 C/G cg22907277 chr7:1156413 C7orf50 0.42 6.25 0.33 1.31e-9 Longevity;Endometriosis; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg14858152 chr1:109289596 STXBP3 0.42 6.06 0.32 3.75e-9 Response to antipsychotic treatment; CRC cis rs6754311 0.593 rs10186843 chr2:136586958 C/A cg15123519 chr2:136567270 LCT 0.33 6.42 0.33 4.79e-10 Mosquito bite size; CRC cis rs1799949 1.000 rs16940 chr17:41245237 A/G cg23758822 chr17:41437982 NA 0.81 13.38 0.59 6.69e-33 Menopause (age at onset); CRC cis rs8177253 1.000 rs8177247 chr3:133479499 T/G cg08048268 chr3:133502702 NA -0.36 -6.91 -0.36 2.59e-11 Iron status biomarkers; CRC cis rs11031096 0.727 rs7932702 chr11:4124372 C/T cg18678763 chr11:4115507 RRM1 -0.51 -8.51 -0.42 6.25e-16 Mean corpuscular volume;Mean corpuscular hemoglobin; CRC cis rs798554 0.757 rs2644312 chr7:2841164 G/A cg17321639 chr7:2759063 NA -0.51 -6.83 -0.35 4.2e-11 Height; CRC cis rs4969178 0.965 rs11077364 chr17:76400337 C/A cg05887092 chr17:76393375 PGS1 0.56 10.01 0.48 9.4e-21 HDL cholesterol levels; CRC cis rs28386778 0.897 rs716880 chr17:61902822 C/G cg23090583 chr17:61904693 PSMC5;FTSJ3 1.05 20.68 0.75 1.83e-61 Prudent dietary pattern; CRC cis rs17253792 0.822 rs10136155 chr14:56049129 G/A cg01858014 chr14:56050164 KTN1 -0.93 -8.37 -0.42 1.65e-15 Putamen volume; CRC cis rs7584330 0.504 rs61213635 chr2:238428132 A/G cg14458575 chr2:238380390 NA 0.44 6.1 0.32 2.96e-9 Prostate cancer; CRC cis rs7804356 0.954 rs3801815 chr7:26881292 T/C cg03456212 chr7:26904342 SKAP2 -0.49 -5.62 -0.3 4.1e-8 Type 1 diabetes; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg13917004 chr19:42462874 RABAC1 0.47 6.8 0.35 5.05e-11 Response to antipsychotic treatment; CRC trans rs7395662 0.591 rs7483212 chr11:48607182 T/A cg15704280 chr7:45808275 SEPT13 -0.48 -6.72 -0.35 7.92e-11 HDL cholesterol; CRC cis rs875971 0.522 rs2949690 chr7:65483242 C/T cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.51 -7.46 -0.38 7.91e-13 Aortic root size; CRC cis rs2180341 0.960 rs6913424 chr6:127707010 A/C cg24812749 chr6:127587940 RNF146 0.96 13.38 0.59 6.9e-33 Breast cancer; CRC cis rs2398893 0.960 rs11788176 chr9:96829243 C/T cg14459158 chr9:96720562 NA 0.49 7.96 0.4 2.81e-14 Waist-hip ratio;Waist-to-hip ratio adjusted for body mass index; CRC cis rs9916302 0.706 rs7208252 chr17:37584368 A/G cg07936489 chr17:37558343 FBXL20 -0.93 -11.84 -0.55 3.62e-27 Glomerular filtration rate (creatinine); CRC cis rs60871478 0.588 rs56205589 chr7:910419 G/A cg13798912 chr7:905769 UNC84A -0.64 -7.05 -0.36 1.09e-11 Cerebrospinal P-tau181p levels; CRC cis rs769267 1.000 rs7246748 chr19:19433105 C/T cg20644253 chr19:19431407 KIAA0892;SF4 -0.41 -5.74 -0.3 2.19e-8 Tonsillectomy; CRC cis rs6570726 0.935 rs406343 chr6:145874388 A/G cg23711669 chr6:146136114 FBXO30 0.7 12.36 0.56 4.27e-29 Lobe attachment (rater-scored or self-reported); CRC trans rs2303319 0.504 rs1567420 chr2:162475601 C/T cg14875682 chr5:52083620 ITGA1;PELO 0.73 5.98 0.31 5.89e-9 Cognitive function; CRC cis rs10946940 1.000 rs10946940 chr6:27560587 A/G cg25164649 chr6:28176230 NA -0.4 -5.69 -0.3 2.78e-8 Systemic lupus erythematosus; CRC cis rs9911578 0.967 rs302843 chr17:56727986 C/T cg12560992 chr17:57184187 TRIM37 0.91 16.63 0.68 1.66e-45 Intelligence (multi-trait analysis); CRC cis rs8067545 0.611 rs2703775 chr17:20134466 A/G cg13482628 chr17:19912719 NA -0.46 -7.35 -0.38 1.55e-12 Schizophrenia; CRC cis rs6763159 0.566 rs2121794 chr3:59644233 A/G cg07069742 chr3:59644285 NA 0.48 9.61 0.47 1.99e-19 Conotruncal heart defects; CRC cis rs4713118 0.784 rs9468219 chr6:27731755 C/A cg25164649 chr6:28176230 NA 0.6 8.01 0.4 1.95e-14 Parkinson's disease; CRC cis rs12144044 0.701 rs2999159 chr1:113230758 A/G cg22162597 chr1:113214053 CAPZA1 -0.63 -7.56 -0.38 3.97e-13 Glomerular filtration rate (creatinine); CRC cis rs7113874 0.569 rs7104646 chr11:8558841 G/T cg20771178 chr11:8615675 STK33 -0.35 -5.81 -0.3 1.5e-8 Body mass index in physically active individuals;Body mass index (joint analysis main effects and physical activity interaction); CRC trans rs6956675 0.831 rs10268923 chr7:62652624 C/G cg01314568 chr7:57830625 NA -0.63 -8.98 -0.44 2.13e-17 Obesity-related traits; CRC trans rs9929218 0.508 rs1559366 chr16:68799611 A/G cg04657470 chr2:198365150 HSPE1;HSPD1 0.91 16.19 0.67 8.83e-44 Colorectal cancer; CRC cis rs972578 0.967 rs2038059 chr22:43334398 T/G cg01576275 chr22:43409880 NA -0.41 -6.36 -0.33 6.77e-10 Mean platelet volume; CRC cis rs11628318 0.614 rs7155883 chr14:103123404 A/C cg23071808 chr14:103021642 NA 0.63 7.04 0.36 1.14e-11 Platelet count; CRC cis rs6546550 0.901 rs4852375 chr2:70125988 C/G cg02498382 chr2:70120550 SNRNP27 -0.55 -9.37 -0.46 1.23e-18 Prevalent atrial fibrillation; CRC cis rs28386778 0.897 rs2597634 chr17:61878144 G/A cg06873352 chr17:61820015 STRADA 0.8 15.3 0.64 2.82e-40 Prudent dietary pattern; CRC cis rs56283067 0.847 rs10948156 chr6:44689459 G/A cg18551225 chr6:44695536 NA -0.41 -5.96 -0.31 6.36e-9 Total body bone mineral density; CRC cis rs2739330 0.760 rs5751761 chr22:24243736 A/G cg10819733 chr22:24237672 NA 0.34 5.8 0.3 1.53e-8 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs243505 0.762 rs1019218 chr7:148488964 C/T cg09806900 chr7:148480153 CUL1 0.52 7.56 0.38 3.94e-13 Inflammatory bowel disease;Crohn's disease; CRC cis rs2072510 0.593 rs2247304 chr12:96424665 T/C cg15438951 chr12:96389694 HAL -0.5 -6.25 -0.33 1.29e-9 Metabolite levels (small molecules and protein measures); CRC cis rs6570726 0.577 rs9497315 chr6:145791967 C/T cg05347473 chr6:146136440 FBXO30 -0.47 -6.77 -0.35 5.77e-11 Lobe attachment (rater-scored or self-reported); CRC cis rs950169 1.000 rs79318564 chr15:84786150 G/A cg17507749 chr15:85114479 UBE2QP1 0.76 11.75 0.54 7.34e-27 Schizophrenia; CRC trans rs7615952 0.512 rs2979351 chr3:125363599 C/T cg03844506 chr4:4109441 NA -0.51 -7.53 -0.38 5.02e-13 Blood pressure (smoking interaction); CRC cis rs9443645 0.505 rs9359364 chr6:79795992 G/A cg05283184 chr6:79620031 NA -0.43 -6.05 -0.32 3.95e-9 Intelligence (multi-trait analysis); CRC cis rs4363385 0.818 rs529077 chr1:153012149 T/C cg25856811 chr1:152973957 SPRR3 -0.25 -6.99 -0.36 1.51e-11 Inflammatory skin disease; CRC cis rs4713118 0.513 rs149878 chr6:27878738 T/G cg15786705 chr6:28176104 NA 0.64 9.31 0.46 1.89e-18 Parkinson's disease; CRC cis rs3749237 1.000 rs2307021 chr3:49765483 C/G cg03060546 chr3:49711283 APEH 0.56 8.33 0.42 2.26e-15 Resting heart rate; CRC cis rs875971 0.965 rs697968 chr7:65535033 G/A cg11764359 chr7:65958608 NA -0.6 -9.5 -0.46 4.46e-19 Aortic root size; CRC cis rs11212617 0.967 rs396552 chr11:108221483 G/C cg12106634 chr11:108092400 ATM;NPAT 0.39 5.67 0.3 3.21e-8 Response to metformin in type 2 diabetes (glycemic); CRC cis rs6570726 0.791 rs6902404 chr6:145905254 G/A cg13319975 chr6:146136371 FBXO30 -0.4 -5.84 -0.31 1.25e-8 Lobe attachment (rater-scored or self-reported); CRC cis rs7843479 0.601 rs11135764 chr8:21814004 A/G cg17168535 chr8:21777572 XPO7 0.6 10.14 0.49 3.34e-21 Mean corpuscular volume; CRC cis rs4563143 0.675 rs56293553 chr19:29270455 A/G cg03161606 chr19:29218774 NA 0.53 6.7 0.35 8.96e-11 Methadone dose in opioid dependence; CRC cis rs11098499 0.644 rs10050092 chr4:120532085 T/C cg09307838 chr4:120376055 NA 0.6 9.1 0.45 9.16e-18 Corneal astigmatism; CRC cis rs7618915 0.547 rs6768697 chr3:52703615 C/T cg11645453 chr3:52864694 ITIH4 0.37 6.41 0.33 4.91e-10 Bipolar disorder; CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg24351916 chr3:39452635 SNORA62;RPSA -0.41 -6.39 -0.33 5.53e-10 Obesity-related traits; CRC cis rs459571 1.000 rs459571 chr9:136912626 C/T cg13789015 chr9:136890014 NCRNA00094 0.44 5.7 0.3 2.66e-8 Platelet distribution width; CRC cis rs709400 0.663 rs28444993 chr14:103930564 T/C cg12935359 chr14:103987150 CKB -0.5 -8.08 -0.41 1.26e-14 Body mass index; CRC cis rs6543140 0.890 rs61122764 chr2:102999520 A/G cg04239558 chr2:103089729 SLC9A4 0.36 6.07 0.32 3.47e-9 Blood protein levels; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg06097357 chr14:35591625 PPP2R3C;KIAA0391 0.44 6.13 0.32 2.47e-9 Response to antipsychotic treatment; CRC cis rs13108904 0.875 rs10024013 chr4:1280792 C/T cg20887711 chr4:1340912 KIAA1530 -0.48 -7.04 -0.36 1.1e-11 Obesity-related traits; CRC cis rs2839186 0.588 rs2839140 chr21:47616080 G/A cg13126279 chr21:47581558 C21orf56 0.38 6.1 0.32 2.93e-9 Testicular germ cell tumor; CRC cis rs875971 0.545 rs11767262 chr7:65767224 T/A cg18876405 chr7:65276391 NA 0.45 6.39 0.33 5.75e-10 Aortic root size; CRC cis rs1971762 0.527 rs9737721 chr12:54074696 A/T cg06632207 chr12:54070931 ATP5G2 0.44 7.45 0.38 8.3e-13 Height; CRC cis rs9611519 0.828 rs4822008 chr22:41539206 C/G cg03806693 chr22:41940476 POLR3H -0.58 -7.21 -0.37 3.95e-12 Neuroticism; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg17470637 chr19:8478017 MARCH2 0.38 6.14 0.32 2.42e-9 Liver disease severity in Alagille syndrome; CRC cis rs6748734 0.779 rs6437371 chr2:241797424 G/C cg16358738 chr2:241808595 AGXT -0.4 -6.25 -0.33 1.24e-9 Urinary metabolites; CRC cis rs7215564 0.908 rs34969384 chr17:78678716 A/G cg09596252 chr17:78655493 RPTOR 0.56 6.15 0.32 2.26e-9 Myopia (pathological); CRC cis rs2228479 0.867 rs11642451 chr16:89958127 T/C cg12064134 chr16:90016061 DEF8 -0.62 -5.62 -0.3 4.11e-8 Skin colour saturation; CRC cis rs736408 0.609 rs2268025 chr3:52795224 A/T cg10802521 chr3:52805072 NEK4 -0.59 -8.96 -0.44 2.54e-17 Bipolar disorder; CRC cis rs4253772 0.688 rs113928699 chr22:46649344 G/A cg24881330 chr22:46731750 TRMU 0.57 5.65 0.3 3.51e-8 LDL cholesterol;Cholesterol, total; CRC cis rs992157 0.798 rs12053514 chr2:219167965 C/T cg13835894 chr2:219148914 PNKD;TMBIM1 -0.34 -6.4 -0.33 5.45e-10 Colorectal cancer; CRC trans rs3733585 0.725 rs10939636 chr4:9972640 T/G cg26043149 chr18:55253948 FECH -0.49 -7.42 -0.38 1.02e-12 Cleft plate (environmental tobacco smoke interaction); CRC cis rs8067545 0.611 rs2158472 chr17:20171524 C/T cg13482628 chr17:19912719 NA -0.48 -7.62 -0.39 2.73e-13 Schizophrenia; CRC trans rs7615952 0.800 rs11915699 chr3:125632684 A/G cg07211511 chr3:129823064 LOC729375 -1.12 -17.62 -0.7 2.02e-49 Blood pressure (smoking interaction); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg25508545 chr19:49467065 FTL 0.45 6.85 0.35 3.65e-11 Response to antipsychotic treatment; CRC cis rs11098499 0.954 rs3733523 chr4:120423719 C/T cg24375607 chr4:120327624 NA 0.48 7.36 0.38 1.5e-12 Corneal astigmatism; CRC cis rs2576037 0.526 rs10853544 chr18:44474194 T/C cg19077165 chr18:44547161 KATNAL2 -0.61 -10.3 -0.49 9.51e-22 Personality dimensions; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg13797228 chr3:126076243 KLF15 0.47 6.68 0.35 9.96e-11 Anxiety disorder; CRC cis rs3858526 0.834 rs10839166 chr11:6002464 T/C cg13902645 chr11:5959945 NA -0.52 -6.81 -0.35 4.78e-11 DNA methylation (variation); CRC cis rs6066835 0.867 rs6090900 chr20:47364120 C/A cg18078177 chr20:47281410 PREX1 0.62 5.72 0.3 2.35e-8 Multiple myeloma; CRC cis rs7223966 0.921 rs3020612 chr17:61960878 C/T cg23903597 chr17:61704154 MAP3K3 -0.44 -6.05 -0.32 3.99e-9 Hip circumference adjusted for BMI;Body mass index; CRC cis rs7312774 0.618 rs2888892 chr12:107328071 C/T cg16260113 chr12:107380972 MTERFD3 0.82 7.93 0.4 3.37e-14 Severe influenza A (H1N1) infection; CRC cis rs7914558 1.000 rs4917996 chr10:104925829 A/C cg04362960 chr10:104952993 NT5C2 0.59 8.71 0.43 1.46e-16 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs853679 0.517 rs9380057 chr6:28104634 G/T cg02631126 chr6:28058918 ZSCAN12L1 0.29 5.89 0.31 9.41e-9 Depression; CRC cis rs10078 0.571 rs890977 chr5:476910 T/C cg24955955 chr5:415729 AHRR 0.67 6.33 0.33 8.04e-10 Fat distribution (HIV); CRC cis rs71403859 0.502 rs75986475 chr16:71464058 C/G cg08717414 chr16:71523259 ZNF19 -0.83 -8.17 -0.41 6.61e-15 Post bronchodilator FEV1; CRC cis rs2573652 0.723 rs4577068 chr15:100515959 T/A cg09918751 chr15:100517450 ADAMTS17 -0.38 -5.78 -0.3 1.72e-8 Height; CRC cis rs12926788 0.689 rs1862450 chr16:24856775 A/G cg00339695 chr16:24857497 SLC5A11 -0.33 -6.16 -0.32 2.12e-9 Ejection fraction in Tripanosoma cruzi seropositivity; CRC cis rs8060686 0.641 rs7201742 chr16:68099821 T/G cg26727032 chr16:67993705 SLC12A4 -0.6 -8.16 -0.41 7.42e-15 HDL cholesterol;Metabolic syndrome; CRC cis rs4803480 0.766 rs115449590 chr19:42088883 T/C cg08478046 chr19:42093086 CEACAM21 -0.31 -6.08 -0.32 3.27e-9 Schizophrenia; CRC cis rs7647973 0.925 rs11130183 chr3:49228946 A/G cg07690219 chr3:49449608 TCTA;RHOA -0.51 -5.96 -0.31 6.32e-9 Menarche (age at onset); CRC cis rs2302190 1.000 rs7207286 chr17:56514458 A/C cg12560992 chr17:57184187 TRIM37 -0.52 -6.59 -0.34 1.74e-10 Vitamin D levels; CRC cis rs66573146 1.000 rs28729690 chr4:6962061 C/T cg26116260 chr4:7069785 GRPEL1 -0.8 -6.51 -0.34 2.86e-10 Granulocyte percentage of myeloid white cells; CRC cis rs7589728 1.000 rs2363731 chr2:88521793 C/T cg04511125 chr2:88470314 THNSL2 0.73 7.5 0.38 5.96e-13 Plasma clusterin levels; CRC cis rs916888 0.773 rs1378358 chr17:44787312 C/T cg01570182 chr17:44337453 NA 1.26 14.05 0.61 1.96e-35 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs4927850 0.709 rs6783079 chr3:195652708 T/C cg01181863 chr3:195395398 SDHAP2 -0.77 -9.94 -0.48 1.53e-20 Pancreatic cancer; CRC cis rs11252926 0.797 rs61837235 chr10:489363 G/A cg18196295 chr10:418757 DIP2C -0.57 -7.91 -0.4 3.83e-14 Psychosis in Alzheimer's disease; CRC cis rs7666738 0.830 rs13125432 chr4:98961253 G/A cg17366294 chr4:99064904 C4orf37 0.43 7.36 0.38 1.49e-12 Colonoscopy-negative controls vs population controls; CRC cis rs7632954 0.596 rs9837823 chr3:8514282 C/G cg03495237 chr3:8533978 NA 0.34 6.32 0.33 8.42e-10 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs6570726 0.846 rs7762536 chr6:145923145 T/C cg13319975 chr6:146136371 FBXO30 -0.42 -6.29 -0.33 1.01e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs12908161 1.000 rs12910012 chr15:85298662 T/C cg11189052 chr15:85197271 WDR73 0.58 8.43 0.42 1.1e-15 Schizophrenia; CRC cis rs863345 0.604 rs1578762 chr1:158497440 G/A cg12129480 chr1:158549410 OR10X1 -0.29 -5.95 -0.31 6.94e-9 Pneumococcal bacteremia; CRC cis rs4929949 0.902 rs61875898 chr11:8627224 C/A cg17679104 chr11:8615758 STK33 0.35 5.69 0.3 2.82e-8 Body mass index; CRC cis rs2153535 0.584 rs62395678 chr6:8371689 C/T cg21535247 chr6:8435926 SLC35B3 -0.41 -6.0 -0.31 5.22e-9 Motion sickness; CRC cis rs514406 0.644 rs4926928 chr1:53210163 G/T cg25767906 chr1:53392781 SCP2 -0.43 -6.73 -0.35 7.35e-11 Monocyte count; CRC cis rs11585357 0.501 rs72646775 chr1:17592121 T/C cg08277548 chr1:17600880 PADI3 -0.67 -7.66 -0.39 2.12e-13 Hair shape; CRC cis rs62064224 0.614 rs8065246 chr17:30682274 T/C cg09324608 chr17:30823087 MYO1D 0.33 5.71 0.3 2.52e-8 Schizophrenia; CRC cis rs896854 0.654 rs28591375 chr8:95973637 C/G cg16049864 chr8:95962084 TP53INP1 -0.65 -11.8 -0.55 5.04e-27 Type 2 diabetes; CRC cis rs6120849 0.754 rs3818253 chr20:33596876 C/T cg24642439 chr20:33292090 TP53INP2 0.43 5.74 0.3 2.13e-8 Protein C levels; CRC cis rs34375054 0.526 rs7302475 chr12:125677886 T/C cg05341575 chr12:125625032 AACS -0.38 -5.88 -0.31 1.01e-8 Post bronchodilator FEV1/FVC ratio; CRC cis rs7772486 0.686 rs9376956 chr6:145949844 T/C cg13319975 chr6:146136371 FBXO30 -0.43 -6.37 -0.33 6.39e-10 Lobe attachment (rater-scored or self-reported); CRC cis rs9311474 0.539 rs12489828 chr3:52567014 G/T cg17372223 chr3:52568218 NT5DC2 0.4 6.29 0.33 1.02e-9 Electroencephalogram traits; CRC cis rs2281845 0.826 rs4915215 chr1:201077212 C/T cg17810781 chr1:201082982 CACNA1S -0.42 -7.02 -0.36 1.28e-11 Permanent tooth development; CRC cis rs908922 0.676 rs945788 chr1:152512762 A/G cg23254163 chr1:152506842 NA 0.44 8.48 0.42 7.52e-16 Hair morphology; CRC cis rs2072499 0.966 rs11587860 chr1:156156951 G/C cg06970220 chr1:156163860 SLC25A44 0.48 6.86 0.35 3.39e-11 Testicular germ cell tumor; CRC cis rs9733 0.596 rs7529998 chr1:150662531 C/T cg10589385 chr1:150898437 SETDB1 0.28 5.98 0.31 5.86e-9 Tonsillectomy; CRC cis rs9491140 0.539 rs10457447 chr6:124698568 A/C cg05308643 chr6:124982296 NKAIN2 -0.58 -6.94 -0.36 2.06e-11 Neuroticism; CRC cis rs9372498 0.536 rs13437605 chr6:118899014 C/T cg10217327 chr6:118973057 C6orf204 0.52 5.89 0.31 9.38e-9 Diastolic blood pressure; CRC cis rs868943 0.743 rs13192924 chr6:116352332 T/C cg26893134 chr6:116381904 FRK 0.27 6.46 0.34 3.67e-10 Total cholesterol levels; CRC cis rs1971762 0.527 rs1247957 chr12:53961493 G/T cg06632207 chr12:54070931 ATP5G2 -0.49 -8.35 -0.42 1.95e-15 Height; CRC cis rs7772486 0.686 rs9497395 chr6:146013592 A/G cg05347473 chr6:146136440 FBXO30 -0.39 -5.85 -0.31 1.17e-8 Lobe attachment (rater-scored or self-reported); CRC cis rs7781266 0.895 rs17167170 chr7:133302345 A/G cg03336402 chr7:133662267 EXOC4 0.49 5.98 0.31 5.75e-9 Educational attainment (college completion); CRC cis rs6952808 0.500 rs3778996 chr7:2177190 G/A cg02951883 chr7:2050386 MAD1L1 -0.6 -8.89 -0.44 3.98e-17 Bipolar disorder and schizophrenia; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg05075067 chr2:28113413 BRE;RBKS;LOC100302650 0.4 6.45 0.34 4.05e-10 Liver disease severity in Alagille syndrome; CRC cis rs7927771 0.524 rs2290851 chr11:47753370 C/T cg20307385 chr11:47447363 PSMC3 -0.45 -6.45 -0.33 4.05e-10 Subjective well-being; CRC cis rs7605827 0.930 rs12995845 chr2:15520539 C/T cg19274914 chr2:15703543 NA 0.4 5.94 0.31 7.08e-9 Educational attainment (years of education); CRC cis rs524281 0.861 rs9736673 chr11:65924024 T/A cg14036092 chr11:66035641 RAB1B -0.46 -5.87 -0.31 1.09e-8 Electroencephalogram traits; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg00400334 chr2:85981962 ATOH8 0.46 6.62 0.34 1.48e-10 Response to antipsychotic treatment; CRC cis rs11758351 1.000 rs11755210 chr6:26202768 C/T cg01420254 chr6:26195488 NA 0.84 8.64 0.43 2.44e-16 Gout;Renal underexcretion gout; CRC cis rs35306767 0.903 rs34847097 chr10:902252 A/T cg20503657 chr10:835505 NA 0.86 10.95 0.52 5.46e-24 Eosinophil percentage of granulocytes; CRC cis rs1448094 0.512 rs6539924 chr12:86236935 T/C cg00310523 chr12:86230176 RASSF9 0.34 5.63 0.3 3.78e-8 Major depressive disorder; CRC cis rs6570726 0.755 rs2103633 chr6:145894021 C/T cg13319975 chr6:146136371 FBXO30 -0.42 -6.22 -0.32 1.53e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs117623576 0.680 rs72777120 chr10:32367608 A/G cg03047570 chr10:32398778 NA -0.62 -6.92 -0.36 2.39e-11 Anti-saccade response; CRC cis rs11758351 1.000 rs11754744 chr6:26202605 G/A cg22723502 chr6:26240528 HIST1H4F -0.39 -5.89 -0.31 9.33e-9 Gout;Renal underexcretion gout; CRC cis rs9488822 0.676 rs12154016 chr6:116355188 C/T cg05304507 chr6:116381966 FRK 0.3 8.15 0.41 7.84e-15 Cholesterol, total;LDL cholesterol; CRC cis rs10791097 0.667 rs4937585 chr11:130741940 A/G cg12179176 chr11:130786555 SNX19 0.75 12.66 0.57 3.28e-30 Autism spectrum disorder or schizophrenia;Schizophrenia; CRC cis rs826838 0.935 rs4583043 chr12:38645147 T/G cg26384229 chr12:38710491 ALG10B 0.69 9.69 0.47 1.11e-19 Heart rate; CRC cis rs9659323 0.730 rs10923720 chr1:119541879 T/C cg26570165 chr1:119541833 NA -0.43 -7.17 -0.37 4.93e-12 Body mass index; CRC cis rs919433 1.000 rs112572902 chr2:198175179 G/C cg10820045 chr2:198174542 NA -0.57 -11.62 -0.54 2.2e-26 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC cis rs4964805 0.954 rs11111786 chr12:104189057 T/C cg02344784 chr12:104178138 NT5DC3 0.56 8.51 0.42 6.45e-16 Attention deficit hyperactivity disorder; CRC cis rs11625487 0.957 rs28820314 chr14:77963272 A/C cg20045696 chr14:77926864 AHSA1 -0.55 -6.68 -0.35 1.01e-10 Neutrophil percentage of white cells;Sum neutrophil eosinophil counts;Neutrophil count; CRC cis rs10128264 0.934 rs1250589 chr10:80980304 C/G cg18737081 chr10:80999807 ZMIZ1 -0.37 -6.52 -0.34 2.67e-10 Response to methotrexate in juvenile idiopathic arthritis; CRC cis rs7107174 1.000 rs2512544 chr11:77986371 A/T cg02023728 chr11:77925099 USP35 0.53 7.85 0.4 5.9e-14 Testicular germ cell tumor; CRC cis rs9393777 0.513 rs9379905 chr6:26630990 G/A cg12292205 chr6:26970375 C6orf41 -0.6 -6.75 -0.35 6.71e-11 Intelligence (multi-trait analysis); CRC cis rs75920871 0.588 rs7101763 chr11:116941985 G/T cg01368799 chr11:117014884 PAFAH1B2 -0.43 -5.9 -0.31 8.99e-9 Subjective well-being; CRC cis rs12024301 0.557 rs74832909 chr1:183646077 G/A cg11505048 chr1:183622726 RGL1;APOBEC4 0.73 6.43 0.33 4.43e-10 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs7945705 0.902 rs7930026 chr11:9013639 T/C cg14711859 chr11:8959438 ASCL3 -0.45 -7.16 -0.37 5.31e-12 Hemoglobin concentration; CRC cis rs7940866 0.804 rs10894287 chr11:130808483 C/T cg12179176 chr11:130786555 SNX19 0.65 9.64 0.47 1.52e-19 Schizophrenia; CRC trans rs2303319 0.504 rs62189043 chr2:162608466 A/T cg14875682 chr5:52083620 ITGA1;PELO -0.73 -6.16 -0.32 2.11e-9 Cognitive function; CRC cis rs17532515 0.628 rs1494808 chr4:141483735 A/C cg09181644 chr4:141490428 UCP1 0.32 5.78 0.3 1.71e-8 Select biomarker traits; CRC cis rs3785574 0.927 rs2854160 chr17:61977248 C/T cg06601766 chr17:61851465 DDX42;CCDC47 0.58 7.95 0.4 2.93e-14 Height; CRC cis rs7746199 0.668 rs7749305 chr6:27446566 T/C cg03623178 chr6:28175578 NA 0.75 5.99 0.31 5.52e-9 Gait speed in old age;Autism spectrum disorder or schizophrenia; CRC cis rs9467711 0.538 rs7750960 chr6:25887217 A/C cg08501292 chr6:25962987 TRIM38 0.98 9.07 0.45 1.09e-17 Autism spectrum disorder or schizophrenia; CRC trans rs587242 1.000 rs12757248 chr1:96898294 G/A cg10631902 chr5:14652156 NA 0.44 6.84 0.35 3.84e-11 Body mass index (joint analysis main effects and physical activity interaction);Body mass index in physically inactive individuals;Body mass index; CRC trans rs11039798 0.588 rs666165 chr11:48457439 C/T cg03929089 chr4:120376271 NA -0.62 -6.65 -0.34 1.19e-10 Axial length; CRC cis rs34375054 0.624 rs12826658 chr12:125680237 A/G cg06287003 chr12:125626642 AACS -0.58 -7.66 -0.39 2.09e-13 Post bronchodilator FEV1/FVC ratio; CRC cis rs12497850 0.931 rs4974080 chr3:49030828 A/C cg07636037 chr3:49044803 WDR6 1.02 18.23 0.71 8.01e-52 Parkinson's disease; CRC cis rs7493 0.950 rs7785846 chr7:95033841 C/T cg19678392 chr7:94953810 PON1 -0.57 -7.19 -0.37 4.31e-12 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs4588572 0.643 rs10044028 chr5:77794750 C/T cg11547950 chr5:77652471 NA 0.53 7.38 0.38 1.33e-12 Triglycerides; CRC cis rs2204008 0.583 rs12820907 chr12:37990931 T/C cg13010199 chr12:38710504 ALG10B 0.47 6.23 0.32 1.4e-9 Bladder cancer; CRC cis rs13108904 0.875 rs10024013 chr4:1280792 C/T cg16405210 chr4:1374714 KIAA1530 0.43 6.24 0.33 1.33e-9 Obesity-related traits; CRC cis rs10504229 0.595 rs76447299 chr8:58117395 A/G cg02725872 chr8:58115012 NA -0.64 -11.55 -0.54 3.85e-26 Developmental language disorder (linguistic errors); CRC cis rs8077889 0.956 rs55768269 chr17:41888997 C/T cg26893861 chr17:41843967 DUSP3 0.95 12.22 0.56 1.43e-28 Triglycerides; CRC cis rs4665809 0.793 rs6546715 chr2:26261520 G/A cg22920501 chr2:26401640 FAM59B -0.49 -6.83 -0.35 4.12e-11 Gut microbiome composition (summer); CRC cis rs7493 0.950 rs17166868 chr7:95033416 C/T cg04871131 chr7:94954202 PON1 -0.46 -5.61 -0.3 4.23e-8 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs904251 0.861 rs2776877 chr6:37487135 G/A cg25019722 chr6:37503610 NA -0.5 -9.29 -0.46 2.17e-18 Cognitive performance; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg10668512 chr15:42565522 GANC;TMEM87A 0.47 6.74 0.35 7.14e-11 Response to antipsychotic treatment; CRC cis rs875971 0.862 rs10950043 chr7:65988610 T/C cg18252515 chr7:66147081 NA -0.43 -6.21 -0.32 1.61e-9 Aortic root size; CRC cis rs9814567 0.865 rs9834981 chr3:134282279 T/G cg06109529 chr3:134205091 CEP63;ANAPC13 -0.82 -12.48 -0.57 1.53e-29 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs908922 0.676 rs7547628 chr1:152527738 T/C cg09873164 chr1:152488093 CRCT1 0.35 5.9 0.31 9e-9 Hair morphology; CRC cis rs10751667 0.643 rs7396046 chr11:937176 T/C cg23136738 chr11:925521 AP2A2 -0.42 -6.98 -0.36 1.65e-11 Alzheimer's disease (late onset); CRC cis rs1881396 0.947 rs77350364 chr2:27866139 A/G cg27432699 chr2:27873401 GPN1 0.63 8.08 0.41 1.28e-14 Nonalcoholic fatty liver disease; CRC cis rs7618915 0.547 rs4687548 chr3:52666650 A/T cg08222913 chr3:52553049 STAB1 -0.34 -6.21 -0.32 1.63e-9 Bipolar disorder; CRC cis rs208515 0.556 rs1872309 chr6:66660432 A/C cg07460842 chr6:66804631 NA 0.73 9.2 0.45 4.12e-18 Exhaled nitric oxide levels; CRC cis rs4969178 0.896 rs11077361 chr17:76397128 A/G cg20026190 chr17:76395443 PGS1 0.4 6.17 0.32 2.06e-9 HDL cholesterol levels; CRC cis rs11148252 0.875 rs9568728 chr13:52946593 C/T cg02158880 chr13:53174818 NA 0.42 6.41 0.33 5.11e-10 Lewy body disease; CRC cis rs459193 0.912 rs27984 chr5:55802419 C/T cg00049729 chr5:55776345 NA 0.39 5.8 0.3 1.58e-8 Coronary artery disease;Type 2 diabetes;Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);Waist-to-hip ratio adjusted for BMI in non-smokers;Waist-to-hip ratio adjusted for BMI (smoking interaction);Waist-to-hip ratio adjusted for body mass index;Waist-hip ratio;Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction); CRC cis rs10256972 0.869 rs4720158 chr7:1040325 A/G cg07930192 chr7:1003750 NA 0.4 6.15 0.32 2.21e-9 Longevity;Endometriosis; CRC cis rs2153535 0.580 rs2327064 chr6:8454052 C/T cg07606381 chr6:8435919 SLC35B3 0.68 10.96 0.52 5.09e-24 Motion sickness; CRC cis rs10751667 0.666 rs10902242 chr11:949700 G/A ch.11.42038R chr11:967971 AP2A2 0.57 9.77 0.47 5.76e-20 Alzheimer's disease (late onset); CRC cis rs7769051 0.808 rs1467404 chr6:133090141 A/G cg22852734 chr6:133119734 C6orf192 -0.91 -10.93 -0.52 6.17e-24 Type 2 diabetes nephropathy; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg01497487 chr22:38141814 TRIOBP 0.51 7.37 0.38 1.39e-12 Response to antipsychotic treatment; CRC cis rs4938330 0.552 rs3882895 chr11:117090545 T/C cg01368799 chr11:117014884 PAFAH1B2 -0.47 -6.06 -0.32 3.66e-9 Blood protein levels; CRC cis rs4474465 1.000 rs7943815 chr11:78173160 A/G cg27205649 chr11:78285834 NARS2 -0.47 -5.95 -0.31 6.95e-9 Alzheimer's disease (survival time); CRC cis rs853679 0.517 rs9368557 chr6:28131537 T/C cg12273811 chr6:28175739 NA 0.73 9.16 0.45 5.8e-18 Depression; CRC cis rs2463822 0.925 rs12292586 chr11:62156312 C/T cg06239285 chr11:62104954 ASRGL1 -1.0 -10.87 -0.51 1.01e-23 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs4654899 0.865 rs7532667 chr1:21438239 A/G cg02927042 chr1:21476669 EIF4G3 -0.53 -8.22 -0.41 4.73e-15 Superior frontal gyrus grey matter volume; CRC cis rs1005277 0.579 rs1740735 chr10:38497777 A/C cg17219203 chr10:38645113 HSD17B7P2 -0.42 -5.95 -0.31 6.98e-9 Extrinsic epigenetic age acceleration; CRC cis rs12348691 0.503 rs7046645 chr9:100617375 T/C cg13688889 chr9:100608707 NA -0.47 -6.05 -0.32 3.87e-9 Alopecia areata; CRC cis rs9733 0.596 rs6661872 chr1:150628357 C/G cg18016565 chr1:150552671 MCL1 0.46 6.74 0.35 6.91e-11 Tonsillectomy; CRC cis rs910316 0.935 rs2268620 chr14:75640403 G/A cg03030879 chr14:75389066 RPS6KL1 0.47 7.21 0.37 3.97e-12 Height; CRC cis rs9733 0.536 rs10888385 chr1:150574302 T/C cg13175981 chr1:150552382 MCL1 0.41 5.84 0.31 1.22e-8 Tonsillectomy; CRC cis rs951366 0.617 rs9438393 chr1:205782718 A/G cg26354017 chr1:205819088 PM20D1 0.92 15.75 0.66 4.68e-42 Menarche (age at onset); CRC trans rs2243480 1.000 rs313814 chr7:65503293 C/A cg10756647 chr7:56101905 PSPH 0.75 7.66 0.39 2.05e-13 Diabetic kidney disease; CRC cis rs644799 1.000 rs487609 chr11:95588102 T/G cg25478527 chr11:95522999 CEP57;FAM76B 0.53 8.0 0.4 2.12e-14 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs9467773 0.572 rs62394558 chr6:26604650 G/A cg09904177 chr6:26538194 HMGN4 0.59 8.37 0.42 1.63e-15 Intelligence (multi-trait analysis); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg26464524 chr7:99699573 MCM7;AP4M1 0.36 5.96 0.31 6.53e-9 Liver disease severity in Alagille syndrome; CRC cis rs763014 0.966 rs4984904 chr16:680809 C/G cg04497992 chr16:616212 NHLRC4 0.41 6.38 0.33 5.92e-10 Height; CRC cis rs13108904 0.870 rs12499546 chr4:1255194 C/T cg16405210 chr4:1374714 KIAA1530 -0.43 -6.1 -0.32 2.91e-9 Obesity-related traits; CRC cis rs739401 0.572 rs12276060 chr11:3015572 A/T cg08508325 chr11:3079039 CARS -0.5 -9.23 -0.45 3.38e-18 Longevity; CRC cis rs4819852 0.958 rs756653 chr22:19976845 G/A cg07821417 chr22:19972146 ARVCF 0.45 6.06 0.32 3.63e-9 Pulse pressure; CRC cis rs597539 0.652 rs622082 chr11:68703959 A/G cg21963583 chr11:68658836 MRPL21 0.58 10.42 0.5 3.71e-22 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs9527 0.571 rs10786715 chr10:104620735 G/C cg15744005 chr10:104629667 AS3MT -0.37 -7.59 -0.39 3.24e-13 Arsenic metabolism; CRC trans rs35110281 0.720 rs162393 chr21:44942692 G/A cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.5 8.23 0.41 4.48e-15 Mean corpuscular volume; CRC cis rs4925325 1.000 rs4925325 chr20:60514224 G/A cg06108461 chr20:60628389 TAF4 0.54 6.97 0.36 1.69e-11 Obesity-related traits; CRC trans rs2470578 0.716 rs2733514 chr3:17323931 A/G cg02092906 chr6:83903419 PGM3;RWDD2A -0.45 -6.54 -0.34 2.4e-10 Schizophrenia; CRC cis rs1862618 0.573 rs185220 chr5:56205357 A/G cg12311346 chr5:56204834 C5orf35 -0.95 -13.06 -0.58 1.12e-31 Initial pursuit acceleration; CRC cis rs4713118 0.662 rs9468278 chr6:28028482 C/T cg03623178 chr6:28175578 NA 0.92 12.95 0.58 2.82e-31 Parkinson's disease; CRC cis rs798554 0.721 rs2527680 chr7:2892361 C/T cg17321639 chr7:2759063 NA -0.5 -6.43 -0.33 4.53e-10 Height; CRC cis rs1448094 0.791 rs11117122 chr12:86337749 A/C cg00310523 chr12:86230176 RASSF9 0.44 7.36 0.38 1.5e-12 Major depressive disorder; CRC cis rs7113874 0.569 rs10769924 chr11:8623193 C/A cg20771178 chr11:8615675 STK33 0.35 5.76 0.3 1.92e-8 Body mass index in physically active individuals;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs4665809 1.000 rs11678157 chr2:26321526 T/C cg22920501 chr2:26401640 FAM59B -0.5 -6.99 -0.36 1.5e-11 Gut microbiome composition (summer); CRC cis rs2842992 0.789 rs3818300 chr6:160201677 G/A cg19482086 chr6:160211437 TCP1;MRPL18 0.73 9.6 0.47 2.11e-19 Age-related macular degeneration (geographic atrophy); CRC cis rs11148252 0.904 rs7321964 chr13:53040822 A/G cg12458913 chr13:53173898 NA 0.59 9.19 0.45 4.7e-18 Lewy body disease; CRC cis rs4665809 1.000 rs10048683 chr2:26320519 C/T cg26119090 chr2:26468346 HADHA;HADHB -0.61 -7.88 -0.4 4.9e-14 Gut microbiome composition (summer); CRC cis rs1005277 0.579 rs2474584 chr10:38416389 C/T cg25517755 chr10:38738941 LOC399744 -0.43 -6.25 -0.33 1.27e-9 Extrinsic epigenetic age acceleration; CRC trans rs2303319 0.504 rs62187609 chr2:162431500 C/T cg01422129 chr2:677375 TMEM18 -0.74 -6.01 -0.31 4.85e-9 Cognitive function; CRC cis rs270601 0.710 rs4705852 chr5:131602807 A/G cg04518342 chr5:131593106 PDLIM4 0.52 9.68 0.47 1.19e-19 Acylcarnitine levels; CRC cis rs4919694 1.000 rs74749600 chr10:104732996 T/C cg04362960 chr10:104952993 NT5C2 1.27 11.19 0.53 7.38e-25 Arsenic metabolism; CRC cis rs7412746 0.658 rs11204723 chr1:150731618 T/C cg17724175 chr1:150552817 MCL1 0.49 7.3 0.37 2.19e-12 Melanoma; CRC cis rs875971 0.862 rs908915 chr7:65614651 G/T cg12463550 chr7:65579703 CRCP -0.53 -7.49 -0.38 6.34e-13 Aortic root size; CRC cis rs2019137 0.936 rs2241978 chr2:113954006 A/G cg21610815 chr2:113994035 PAX8;LOC654433;LOC440839 -0.45 -6.42 -0.33 4.82e-10 Lymphocyte counts; CRC cis rs2836974 0.666 rs12626405 chr21:40663121 G/T cg17971929 chr21:40555470 PSMG1 -0.7 -10.78 -0.51 2.1e-23 Cognitive function; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg15114107 chr1:228328228 GUK1 0.38 6.14 0.32 2.42e-9 Liver disease severity in Alagille syndrome; CRC cis rs6570726 0.935 rs425731 chr6:145834151 A/G cg23711669 chr6:146136114 FBXO30 0.68 12.16 0.56 2.33e-28 Lobe attachment (rater-scored or self-reported); CRC cis rs7677751 0.806 rs17084051 chr4:55087581 C/A cg17187183 chr4:55093834 PDGFRA 0.53 7.68 0.39 1.82e-13 Corneal astigmatism; CRC trans rs11098499 0.863 rs3775854 chr4:120471971 C/T cg25214090 chr10:38739885 LOC399744 0.66 10.48 0.5 2.24e-22 Corneal astigmatism; CRC cis rs1348850 0.914 rs11893448 chr2:178280013 T/C cg22681709 chr2:178499509 PDE11A -0.4 -7.55 -0.38 4.25e-13 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs4862750 0.914 rs9995391 chr4:187873749 A/T cg11301795 chr4:187892539 NA 0.81 17.1 0.69 2.47e-47 Lobe attachment (rater-scored or self-reported); CRC cis rs2842992 0.915 rs2758350 chr6:160118056 A/G cg11366901 chr6:160182831 ACAT2 0.88 11.79 0.55 5.15e-27 Age-related macular degeneration (geographic atrophy); CRC cis rs8062405 1.000 rs62036622 chr16:28837203 T/G cg16576597 chr16:28551801 NUPR1 0.42 5.72 0.3 2.45e-8 Cognitive ability (multi-trait analysis);Cognitive ability; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg11637544 chr11:66886765 KDM2A 0.42 6.03 0.32 4.51e-9 Response to antipsychotic treatment; CRC cis rs35883536 0.647 rs7524322 chr1:101047730 C/G cg06223162 chr1:101003688 GPR88 0.34 6.14 0.32 2.44e-9 Monocyte count; CRC trans rs4332037 0.722 rs28705934 chr7:1916116 T/A cg11693508 chr17:37793320 STARD3 0.57 7.08 0.36 8.78e-12 Bipolar disorder; CRC cis rs2153535 0.580 rs9405390 chr6:8466209 T/G cg07606381 chr6:8435919 SLC35B3 0.68 10.9 0.51 8.26e-24 Motion sickness; CRC cis rs6741819 1.000 rs10495549 chr2:7142367 C/T cg27144453 chr2:7172511 RNF144A -0.42 -6.15 -0.32 2.26e-9 Response to antipsychotic treatment; CRC cis rs9457247 1.000 rs364283 chr6:167383750 C/T cg23791538 chr6:167370224 RNASET2 -0.38 -5.95 -0.31 6.86e-9 Crohn's disease; CRC cis rs7666738 0.830 rs11944855 chr4:99068258 G/A cg17366294 chr4:99064904 C4orf37 0.43 7.32 0.37 1.87e-12 Colonoscopy-negative controls vs population controls; CRC cis rs7474896 0.515 rs675628 chr10:38305331 C/G cg25427524 chr10:38739819 LOC399744 0.64 7.84 0.4 6.18e-14 Obesity (extreme); CRC trans rs11098499 0.863 rs9884402 chr4:120489982 A/G cg25214090 chr10:38739885 LOC399744 0.66 10.34 0.5 6.8e-22 Corneal astigmatism; CRC cis rs13064447 0.845 rs11128610 chr3:12761123 G/T cg07775309 chr3:12595852 NA 0.36 5.78 0.3 1.74e-8 Major depression and alcohol dependence; CRC cis rs10242455 0.702 rs73713531 chr7:99222379 C/T cg18809830 chr7:99032528 PTCD1 -1.05 -7.42 -0.38 1.01e-12 Blood metabolite levels; CRC cis rs10504229 0.683 rs56196593 chr8:58141898 G/A cg02725872 chr8:58115012 NA -0.65 -11.62 -0.54 2.2e-26 Developmental language disorder (linguistic errors); CRC trans rs262150 0.851 rs2527224 chr7:158769198 G/A cg21167628 chr1:45308625 PTCH2 -0.38 -6.46 -0.34 3.71e-10 Facial morphology (factor 20); CRC cis rs709400 0.633 rs8013101 chr14:103951772 G/C cg12935359 chr14:103987150 CKB -0.51 -8.2 -0.41 5.32e-15 Body mass index; CRC trans rs2727020 0.587 rs1164658 chr11:49298551 C/A cg15704280 chr7:45808275 SEPT13 0.88 15.75 0.66 4.75e-42 Coronary artery disease; CRC trans rs3808502 0.503 rs2061830 chr8:11397457 C/G cg06636001 chr8:8085503 FLJ10661 0.51 7.54 0.38 4.61e-13 Neuroticism; CRC cis rs9303401 0.659 rs17822807 chr17:56687190 A/C cg10487724 chr17:56770010 TEX14;RAD51C 0.79 9.24 0.45 3.2e-18 Cognitive test performance; CRC cis rs9640161 0.750 rs11538922 chr7:150035183 C/T cg12556325 chr7:150026731 C7orf29;LRRC61 -0.5 -7.34 -0.38 1.71e-12 Blood protein levels;Circulating chemerin levels; CRC cis rs644799 1.000 rs544119 chr11:95538624 G/A cg25622487 chr11:95524042 FAM76B;CEP57 0.76 11.87 0.55 2.62e-27 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs9814567 0.806 rs4955526 chr3:134317337 A/G cg06541857 chr3:134203789 ANAPC13;CEP63 -0.37 -5.84 -0.31 1.27e-8 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs28386778 0.799 rs2665836 chr17:61898135 C/A cg06601766 chr17:61851465 DDX42;CCDC47 0.45 6.14 0.32 2.32e-9 Prudent dietary pattern; CRC cis rs4731207 0.562 rs6975534 chr7:124686461 G/T cg23710748 chr7:124431027 NA -0.39 -6.22 -0.32 1.54e-9 Cutaneous malignant melanoma; CRC cis rs4713118 0.662 rs149969 chr6:27977737 A/G cg03623178 chr6:28175578 NA 0.88 13.28 0.59 1.66e-32 Parkinson's disease; CRC cis rs3015497 0.653 rs2356456 chr14:51093216 A/T cg09863266 chr14:51125203 SAV1 -0.29 -5.63 -0.3 3.9e-8 Mean platelet volume; CRC cis rs2933343 0.729 rs1680794 chr3:128620390 A/G cg11901034 chr3:128598214 ACAD9 -0.56 -8.11 -0.41 1.01e-14 IgG glycosylation; CRC cis rs12484776 0.786 rs6001794 chr22:40529415 A/C cg21771250 chr22:40406049 FAM83F -0.32 -5.83 -0.31 1.35e-8 Uterine fibroids; CRC cis rs9549367 0.713 rs11620600 chr13:113829090 G/A cg18105134 chr13:113819100 PROZ -0.86 -12.81 -0.58 9.07e-31 Platelet distribution width; CRC cis rs2439831 0.557 rs13329084 chr15:44151063 A/G cg02155558 chr15:43621948 ADAL;LCMT2 -0.72 -6.67 -0.35 1.09e-10 Lung cancer in ever smokers; CRC cis rs4925386 0.840 rs8124907 chr20:60913127 A/G cg15193198 chr20:60906057 LAMA5 -0.42 -6.37 -0.33 6.49e-10 Colorectal cancer;Colorectal cancer (SNP x SNP interaction); CRC cis rs9323205 0.765 rs2999387 chr14:51652986 C/G cg23942311 chr14:51606299 NA -0.63 -9.94 -0.48 1.55e-20 Cancer; CRC cis rs7223966 1.000 rs8077265 chr17:61732727 A/G cg23903597 chr17:61704154 MAP3K3 -0.42 -5.75 -0.3 2.07e-8 Hip circumference adjusted for BMI;Body mass index; CRC cis rs1045714 0.836 rs56246161 chr7:2644679 G/A cg24848437 chr7:2645542 IQCE 0.55 5.88 0.31 1.01e-8 Urate levels in lean individuals; CRC cis rs3806843 0.932 rs2563269 chr5:140136468 G/T cg19875535 chr5:140030758 IK -0.58 -9.51 -0.46 4.12e-19 Depressive symptoms (multi-trait analysis); CRC cis rs4665809 1.000 rs2384322 chr2:26291146 C/G cg04944784 chr2:26401820 FAM59B -0.64 -7.9 -0.4 4.09e-14 Gut microbiome composition (summer); CRC cis rs12701220 0.725 rs13242971 chr7:1055515 C/T cg26769984 chr7:1090371 C7orf50 0.71 9.45 0.46 6.4e-19 Bronchopulmonary dysplasia; CRC cis rs970548 0.954 rs11239536 chr10:45978598 T/A cg15590007 chr10:45870220 ALOX5 0.47 5.92 0.31 8.09e-9 Total cholesterol levels;Cholesterol, total;HDL cholesterol;HDL cholesterol levels; CRC trans rs7976838 0.614 rs12578499 chr12:60257018 G/A cg16974014 chr22:22007515 MIR130B 0.51 6.06 0.32 3.67e-9 Response to zileuton treatment in asthma (FEV1 change interaction); CRC cis rs4494114 1.000 rs4491033 chr1:39352083 A/C cg25970120 chr1:39325951 RRAGC -0.45 -6.28 -0.33 1.08e-9 Blood protein levels; CRC cis rs11098499 0.754 rs2036856 chr4:120249288 G/A cg09307838 chr4:120376055 NA 0.62 9.66 0.47 1.37e-19 Corneal astigmatism; CRC cis rs9549367 0.789 rs912012 chr13:113886152 G/A cg18105134 chr13:113819100 PROZ -0.73 -10.94 -0.52 5.91e-24 Platelet distribution width; CRC cis rs2227564 0.794 rs2688607 chr10:75663736 C/T cg00564723 chr10:75632066 CAMK2G 0.3 7.01 0.36 1.35e-11 Crohn's disease;Inflammatory bowel disease; CRC cis rs4713118 0.629 rs172165 chr6:28020814 T/G cg23161317 chr6:28129485 ZNF389 0.43 5.71 0.3 2.46e-8 Parkinson's disease; CRC cis rs1800682 0.528 rs3903454 chr10:90743434 A/T cg13456138 chr10:90753195 FAS 0.4 5.64 0.3 3.71e-8 Chronic lymphocytic leukemia; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg21676273 chr3:45635931 LIMD1 0.42 6.0 0.31 5.24e-9 Response to antipsychotic treatment; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg16143176 chr8:61591199 CHD7 0.37 6.29 0.33 1e-9 Liver disease severity in Alagille syndrome; CRC trans rs2243480 1.000 rs13235972 chr7:65883605 C/T cg10756647 chr7:56101905 PSPH 0.78 8.01 0.4 1.97e-14 Diabetic kidney disease; CRC cis rs733592 0.524 rs10875727 chr12:48426143 T/C cg24011408 chr12:48396354 COL2A1 -0.43 -6.34 -0.33 7.41e-10 Plateletcrit; CRC cis rs9303280 0.901 rs9901146 chr17:38043343 G/A cg20243544 chr17:37824526 PNMT 0.44 6.82 0.35 4.33e-11 Self-reported allergy; CRC cis rs2832191 0.791 rs57721945 chr21:30498744 T/C cg24692254 chr21:30365293 RNF160 -0.67 -11.39 -0.53 1.41e-25 Dental caries; CRC trans rs3942852 0.955 rs6485809 chr11:48112468 C/T cg15704280 chr7:45808275 SEPT13 -0.64 -7.29 -0.37 2.3e-12 Acute lymphoblastic leukemia (childhood); CRC cis rs2933343 0.729 rs789231 chr3:128602847 A/G cg25356066 chr3:128598488 ACAD9 0.39 5.66 0.3 3.22e-8 IgG glycosylation; CRC cis rs2404602 0.647 rs11632765 chr15:76974261 A/T cg03037974 chr15:76606532 NA 0.55 8.73 0.43 1.3e-16 Blood metabolite levels; CRC cis rs294883 0.858 rs9364509 chr6:159703212 G/A cg14500486 chr6:159655392 FNDC1 -0.35 -5.75 -0.3 2.09e-8 Coronary artery disease; CRC cis rs875971 0.862 rs10250544 chr7:65766561 A/G cg11764359 chr7:65958608 NA -0.59 -8.72 -0.43 1.38e-16 Aortic root size; CRC cis rs3008870 0.755 rs2815355 chr1:67485034 A/G cg08660285 chr1:67390436 MIER1;WDR78 0.55 7.79 0.39 8.87e-14 Lymphocyte percentage of white cells; CRC cis rs13191362 1.000 rs34655790 chr6:163202739 G/A cg23758597 chr6:163146217 PARK2 -0.66 -6.79 -0.35 5.28e-11 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs7208859 0.573 rs216443 chr17:28931871 A/G cg13385521 chr17:29058706 SUZ12P 0.55 6.09 0.32 3.23e-9 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs7811142 0.830 rs6955367 chr7:99961194 A/G cg07160278 chr7:100027354 MEPCE;ZCWPW1 0.96 13.84 0.61 1.21e-34 Platelet count; CRC cis rs853679 0.517 rs9393890 chr6:28063855 C/T cg15845792 chr6:28175446 NA 0.99 13.1 0.59 7.48e-32 Depression; CRC cis rs4862750 0.914 rs11943333 chr4:187872455 A/G cg06074448 chr4:187884817 NA -0.56 -10.14 -0.49 3.23e-21 Lobe attachment (rater-scored or self-reported); CRC cis rs7772486 0.754 rs2064185 chr6:146066814 G/A cg23711669 chr6:146136114 FBXO30 -0.75 -12.77 -0.58 1.37e-30 Lobe attachment (rater-scored or self-reported); CRC trans rs6601327 0.634 rs12679956 chr8:9584849 G/A cg06636001 chr8:8085503 FLJ10661 -0.5 -7.3 -0.37 2.13e-12 Multiple myeloma (hyperdiploidy); CRC cis rs8114671 0.562 rs6120757 chr20:33488771 C/T cg07148914 chr20:33460835 GGT7 0.38 6.17 0.32 1.98e-9 Height; CRC cis rs2404602 0.503 rs284909 chr15:76736628 C/T cg23625390 chr15:77176239 SCAPER 0.58 9.04 0.45 1.38e-17 Blood metabolite levels; CRC cis rs7937682 0.632 rs10891297 chr11:111770150 C/T cg19812747 chr11:111475976 SIK2 0.44 6.33 0.33 7.9e-10 Primary sclerosing cholangitis; CRC cis rs1218582 0.772 rs1976559 chr1:154879788 A/T cg06221963 chr1:154839813 KCNN3 -0.76 -15.38 -0.65 1.34e-40 Prostate cancer; CRC cis rs243505 1.000 rs243510 chr7:148432534 A/G cg09806900 chr7:148480153 CUL1 -0.44 -6.05 -0.32 3.92e-9 Inflammatory bowel disease;Crohn's disease; CRC cis rs2739330 0.828 rs2330635 chr22:24251344 T/C cg23131131 chr22:24373011 LOC391322 -0.67 -10.24 -0.49 1.54e-21 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs7638909 0.901 rs9845438 chr3:38600456 A/C cg01465620 chr3:38496096 LOC100128640;ACVR2B -0.46 -5.66 -0.3 3.26e-8 Electrocardiographic conduction measures; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg25653011 chr17:38296442 CASC3 0.43 6.38 0.33 6e-10 Intelligence (multi-trait analysis); CRC cis rs12368653 0.666 rs799265 chr12:58112189 A/G cg00677455 chr12:58241039 CTDSP2 -0.43 -6.17 -0.32 2.02e-9 Multiple sclerosis; CRC cis rs7539542 0.556 rs2275734 chr1:202887295 C/T cg19681188 chr1:202830198 LOC148709 0.43 6.35 0.33 6.97e-10 Mean platelet volume; CRC cis rs362272 0.525 rs910568 chr4:3307373 A/G cg02993699 chr4:3415135 RGS12 -0.38 -6.21 -0.32 1.59e-9 Serum sulfate level; CRC cis rs881375 1.000 rs7037140 chr9:123656327 T/C cg09586646 chr9:123605570 PSMD5;LOC253039 0.53 7.16 0.37 5.25e-12 Rheumatoid arthritis; CRC trans rs11635191 0.636 rs4887125 chr15:74559478 C/G cg06477056 chr5:175110609 HRH2 0.34 6.2 0.32 1.68e-9 Diisocyanate-induced asthma; CRC trans rs6598955 0.671 rs59143843 chr1:26641595 G/T cg07461501 chr17:79650226 HGS;ARL16 -0.55 -6.49 -0.34 3.14e-10 Obesity-related traits; CRC cis rs8077889 0.869 rs11713 chr17:41845824 A/G cg16892393 chr17:41919603 NA -0.4 -5.72 -0.3 2.42e-8 Triglycerides; CRC cis rs2739330 0.828 rs5760107 chr22:24252597 T/C cg24846343 chr22:24311635 DDTL 0.82 14.42 0.62 7.03e-37 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs9372498 0.536 rs62424198 chr6:118827247 A/G cg10217327 chr6:118973057 C6orf204 0.51 5.87 0.31 1.04e-8 Diastolic blood pressure; CRC cis rs651907 0.535 rs17347156 chr3:101504674 G/A cg12386194 chr3:101231763 SENP7 0.51 7.34 0.38 1.71e-12 Colorectal cancer; CRC cis rs478304 0.654 rs6591185 chr11:65455742 A/G cg27068330 chr11:65405492 SIPA1 -0.66 -9.82 -0.48 4.02e-20 Acne (severe); CRC trans rs800082 0.501 rs9878902 chr3:144220319 A/T cg24215973 chr2:240111563 HDAC4 0.49 7.51 0.38 5.45e-13 Smoking behavior; CRC cis rs59698941 0.527 rs7719428 chr5:132180919 C/G cg14825688 chr5:132208181 LEAP2 0.4 6.62 0.34 1.48e-10 Apolipoprotein A-IV levels; CRC trans rs13046373 0.905 rs4816372 chr21:32077414 A/T cg05692643 chr21:43223990 PRDM15 -0.39 -6.14 -0.32 2.35e-9 HDL cholesterol; CRC cis rs35264875 0.950 rs72928659 chr11:68852358 C/T cg15234197 chr11:68924956 NA 0.44 6.1 0.32 2.9e-9 Blond vs. brown hair color; CRC cis rs6502050 0.835 rs7212441 chr17:80080047 T/G cg11859384 chr17:80120422 CCDC57 0.37 5.77 0.3 1.85e-8 Life satisfaction; CRC cis rs2228479 0.702 rs62052710 chr16:89854893 C/T cg06558623 chr16:89946397 TCF25 1.15 10.53 0.5 1.51e-22 Skin colour saturation; CRC cis rs9902453 0.679 rs2054847 chr17:28532013 G/A cg26525008 chr17:28256777 EFCAB5;SSH2 0.54 7.96 0.4 2.79e-14 Coffee consumption (cups per day); CRC cis rs501120 0.584 rs58129751 chr10:44706720 G/A cg09554077 chr10:44749378 NA 0.67 7.44 0.38 8.88e-13 Coronary artery disease;Coronary heart disease; CRC trans rs2413583 0.591 rs79605405 chr22:39696638 C/A cg09612413 chr10:12085555 UPF2 -0.56 -6.21 -0.32 1.58e-9 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; CRC cis rs478304 0.627 rs11227254 chr11:65454000 A/G cg27068330 chr11:65405492 SIPA1 -0.66 -9.8 -0.48 4.69e-20 Acne (severe); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg16109953 chr14:24701739 GMPR2;NEDD8 0.45 6.36 0.33 6.61e-10 Response to antipsychotic treatment; CRC cis rs72781680 0.821 rs113014365 chr2:24159903 C/T cg08917208 chr2:24149416 ATAD2B 0.56 6.76 0.35 6.37e-11 Lymphocyte counts; CRC cis rs4665809 1.000 rs750450 chr2:26324631 A/G cg22920501 chr2:26401640 FAM59B -0.5 -6.61 -0.34 1.56e-10 Gut microbiome composition (summer); CRC cis rs7932354 0.528 rs11039112 chr11:47174296 C/T cg19486271 chr11:47235900 DDB2 0.45 6.66 0.34 1.13e-10 Bone mineral density (hip);Bone mineral density; CRC cis rs1065852 0.526 rs9607869 chr22:42418110 T/A cg00645731 chr22:42541494 CYP2D7P1 0.4 6.84 0.35 3.84e-11 Response to serotonin reuptake inhibitors in major depressive disorder (plasma drug and metabolite levels); CRC cis rs881375 0.678 rs9886724 chr9:123665019 A/G cg14255062 chr9:123606675 PSMD5;LOC253039 0.39 6.08 0.32 3.26e-9 Rheumatoid arthritis; CRC trans rs4714291 0.832 rs761798 chr6:40087514 C/T cg02267698 chr19:7991119 CTXN1 0.49 6.63 0.34 1.41e-10 Strep throat; CRC cis rs11098499 0.954 rs6849561 chr4:120409694 C/G cg09307838 chr4:120376055 NA -0.7 -10.45 -0.5 2.96e-22 Corneal astigmatism; CRC cis rs9527 0.569 rs78193706 chr10:104780564 T/C cg15744005 chr10:104629667 AS3MT -0.3 -5.96 -0.31 6.63e-9 Arsenic metabolism; CRC cis rs12497850 1.000 rs4858828 chr3:48724811 C/T cg20833759 chr3:49053208 WDR6;DALRD3 0.42 7.3 0.37 2.23e-12 Parkinson's disease; CRC cis rs6543140 0.964 rs6543142 chr2:103082006 T/C cg03938978 chr2:103052716 IL18RAP 0.41 6.53 0.34 2.51e-10 Blood protein levels; CRC cis rs7512552 0.839 rs17596326 chr1:150433819 A/G cg15654264 chr1:150340011 RPRD2 0.58 8.22 0.41 4.63e-15 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); CRC cis rs225245 0.791 rs720774 chr17:34017453 T/G cg05299278 chr17:33885742 SLFN14 0.5 8.19 0.41 5.74e-15 Reticulocyte count;Reticulocyte fraction of red cells;High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells; CRC cis rs9660180 0.836 rs72634845 chr1:1704899 G/A cg17747265 chr1:1875780 NA -0.73 -12.44 -0.57 2.19e-29 Body mass index; CRC cis rs2573652 0.755 rs6598286 chr15:100515985 G/T cg00587665 chr15:100533223 ADAMTS17 -0.5 -8.74 -0.43 1.25e-16 Height; CRC cis rs9916302 0.706 rs7503377 chr17:37708841 A/G cg15445000 chr17:37608096 MED1 0.33 5.67 0.3 3.09e-8 Glomerular filtration rate (creatinine); CRC cis rs9532580 0.778 rs61963319 chr13:41244220 A/T cg21288729 chr13:41239152 FOXO1 0.5 7.6 0.39 3.04e-13 Mean corpuscular hemoglobin; CRC cis rs1499614 0.831 rs3800822 chr7:66147149 A/G cg18252515 chr7:66147081 NA 1.25 14.86 0.63 1.38e-38 Gout; CRC cis rs4713118 0.513 rs149989 chr6:27998184 T/A cg02631126 chr6:28058918 ZSCAN12L1 0.24 5.73 0.3 2.23e-8 Parkinson's disease; CRC cis rs7680126 0.597 rs78917351 chr4:10208063 A/C cg00071950 chr4:10020882 SLC2A9 -0.46 -5.97 -0.31 6.02e-9 Urate levels in lean individuals;Urate levels in overweight individuals;Urate levels in obese individuals; CRC trans rs1656966 1.000 rs1656966 chr3:186466252 C/T cg10983056 chr13:113344077 ATP11A 0.4 5.96 0.31 6.44e-9 Myopia (pathological); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg22538323 chr7:27702700 HIBADH 0.49 6.89 0.36 2.8e-11 Response to antipsychotic treatment; CRC trans rs6952808 0.582 rs11763870 chr7:2027448 T/C cg04565464 chr8:145669602 NFKBIL2 -0.43 -6.66 -0.34 1.17e-10 Bipolar disorder and schizophrenia; CRC cis rs4285028 0.747 rs11923248 chr3:121566498 G/T cg11130432 chr3:121712080 ILDR1 -0.49 -5.68 -0.3 3.01e-8 Multiple sclerosis; CRC trans rs75804782 0.935 rs61332075 chr2:239316560 G/C cg01134436 chr17:81009848 B3GNTL1 0.73 6.56 0.34 2.03e-10 Morning vs. evening chronotype;Chronotype; CRC cis rs6909279 0.933 rs9479072 chr6:151890789 C/T cg10883421 chr6:151773342 RMND1;C6orf211 -0.37 -5.62 -0.3 3.98e-8 Bone mineral density; CRC trans rs10155879 0.505 rs12704265 chr7:86142678 A/G cg02567788 chr10:71992279 PPA1 0.58 6.26 0.33 1.2e-9 Interleukin-4 levels; CRC trans rs6076960 0.684 rs6054058 chr20:6262187 T/C cg17788362 chr6:86352627 SYNCRIP 0.56 7.89 0.4 4.52e-14 Smooth-surface caries; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg16956456 chr5:172483378 C5orf41 0.53 7.07 0.36 9.3e-12 Thyroid stimulating hormone; CRC cis rs10504229 0.683 rs16921829 chr8:58110950 A/G cg21724239 chr8:58056113 NA 0.5 6.79 0.35 5.25e-11 Developmental language disorder (linguistic errors); CRC cis rs8073060 0.519 rs8065286 chr17:33864479 A/G cg08516792 chr17:33866067 SLFN12L -0.36 -5.96 -0.31 6.52e-9 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; CRC cis rs2842992 0.830 rs2842974 chr6:160159034 C/T cg19482086 chr6:160211437 TCP1;MRPL18 0.71 9.31 0.46 1.86e-18 Age-related macular degeneration (geographic atrophy); CRC cis rs7412746 0.658 rs72704685 chr1:150897687 C/G cg17724175 chr1:150552817 MCL1 0.44 6.71 0.35 8.35e-11 Melanoma; CRC cis rs35110281 0.807 rs2838328 chr21:45023234 G/C cg01579765 chr21:45077557 HSF2BP -0.35 -6.73 -0.35 7.76e-11 Mean corpuscular volume; CRC cis rs8044995 0.517 rs61593058 chr16:68384496 T/C cg05110241 chr16:68378359 PRMT7 -0.62 -7.62 -0.39 2.65e-13 Schizophrenia; CRC cis rs2072499 0.750 rs7534339 chr1:156156219 A/G cg25208724 chr1:156163844 SLC25A44 1.03 16.29 0.67 3.78e-44 Testicular germ cell tumor; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg00767560 chr19:19887256 LOC284440 0.47 6.1 0.32 3.04e-9 Thyroid stimulating hormone; CRC cis rs7909074 1.000 rs4481983 chr10:45400428 G/T cg04218760 chr10:45406644 TMEM72 -0.35 -9.76 -0.47 6.27e-20 Mean corpuscular volume; CRC cis rs4689388 0.889 rs13101355 chr4:6293446 T/C cg14416269 chr4:6271139 WFS1 0.4 6.62 0.34 1.43e-10 Type 2 diabetes and other traits;Type 2 diabetes; CRC trans rs11466653 1.000 rs10029775 chr4:38777875 C/T cg11403706 chr22:49042600 FAM19A5 0.62 6.11 0.32 2.76e-9 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs8180040 0.966 rs11705957 chr3:47443262 T/G cg10298567 chr3:47292165 KIF9 0.38 6.11 0.32 2.74e-9 Colorectal cancer; CRC trans rs853679 0.546 rs493161 chr6:27850714 A/T cg06606381 chr12:133084897 FBRSL1 -0.81 -6.89 -0.36 2.92e-11 Depression; CRC cis rs11606709 1 rs11606709 chr11:46730522 A/G cg19486271 chr11:47235900 DDB2 -0.48 -7.48 -0.38 6.72e-13 Total body bone mineral density; CRC cis rs4822044 0.560 rs7284839 chr22:42010902 C/T cg06481639 chr22:41940642 POLR3H 0.52 5.63 0.3 3.81e-8 Cannabis dependence symptom count; CRC cis rs7772486 0.846 rs1854901 chr6:146325685 T/C cg23711669 chr6:146136114 FBXO30 0.61 10.3 0.49 9.23e-22 Lobe attachment (rater-scored or self-reported); CRC cis rs6976053 0.765 rs12705099 chr7:100518458 C/T cg10426581 chr7:100472382 SRRT 0.37 5.74 0.3 2.1e-8 Plasminogen activator inhibitor type 1 levels (PAI-1); CRC cis rs6693567 0.565 rs1694379 chr1:150292417 C/A cg15654264 chr1:150340011 RPRD2 0.4 5.8 0.3 1.54e-8 Migraine; CRC cis rs909002 0.720 rs4949459 chr1:32142354 G/T cg13919466 chr1:32135498 COL16A1 -0.33 -6.3 -0.33 9.53e-10 Intelligence (multi-trait analysis); CRC cis rs7224685 0.569 rs2123841 chr17:4022557 G/C cg09695851 chr17:3907499 NA 0.48 6.04 0.32 4.12e-9 Type 2 diabetes; CRC cis rs806795 0.605 rs809871 chr6:26256526 C/G cg00631329 chr6:26305371 NA 0.53 8.96 0.44 2.45e-17 Mosquito bite size; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg24859228 chr10:12391835 CAMK1D 0.49 6.36 0.33 6.65e-10 Thyroid stimulating hormone; CRC cis rs13191362 0.935 rs35049401 chr6:162968464 T/G cg21926612 chr6:163149169 PACRG;PARK2 0.85 10.74 0.51 3e-23 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs116095464 0.850 rs10055295 chr5:243749 G/A cg22857025 chr5:266934 NA -1.25 -16.72 -0.68 7.27e-46 Breast cancer; CRC cis rs782590 0.935 rs782568 chr2:55881538 T/C cg18811423 chr2:55921094 PNPT1 0.82 15.47 0.65 5.89e-41 Metabolic syndrome; CRC cis rs2839186 0.559 rs2277826 chr21:47639492 C/G cg13126279 chr21:47581558 C21orf56 0.4 6.02 0.31 4.7e-9 Testicular germ cell tumor; CRC cis rs2032447 0.901 rs2213284 chr6:26031868 G/A cg04800585 chr6:26043546 HIST1H2BB 0.57 8.37 0.42 1.65e-15 Intelligence (multi-trait analysis); CRC cis rs10504229 0.683 rs73603877 chr8:58108428 C/T cg22535103 chr8:58192502 C8orf71 -0.68 -8.76 -0.43 1.08e-16 Developmental language disorder (linguistic errors); CRC cis rs853679 0.550 rs1233707 chr6:28172953 G/A cg03623178 chr6:28175578 NA 0.99 14.94 0.64 6.72e-39 Depression; CRC cis rs9660992 0.547 rs748012 chr1:205216573 C/T cg21643547 chr1:205240462 TMCC2 -0.35 -5.63 -0.3 3.94e-8 Mean corpuscular volume;Mean platelet volume; CRC cis rs7408868 1.000 rs2074617 chr19:15276055 C/G cg14696996 chr19:15285081 NOTCH3 0.97 8.99 0.44 1.99e-17 Pulse pressure; CRC cis rs4660306 1.000 rs4660306 chr1:45978675 C/T cg03123370 chr1:45965343 CCDC163P;MMACHC 0.55 7.92 0.4 3.76e-14 Homocysteine levels; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg22382455 chr15:42787814 SNAP23 0.39 6.26 0.33 1.19e-9 Liver disease severity in Alagille syndrome; CRC cis rs10504229 0.815 rs16921955 chr8:58164553 C/T cg05313129 chr8:58192883 C8orf71 -0.45 -7.13 -0.37 6.27e-12 Developmental language disorder (linguistic errors); CRC cis rs4665809 0.590 rs2303892 chr2:26461733 C/G cg08067268 chr2:26466485 HADHB;HADHA 0.66 8.38 0.42 1.54e-15 Gut microbiome composition (summer); CRC cis rs11758351 0.660 rs11753655 chr6:26220109 C/T cg22723502 chr6:26240528 HIST1H4F -0.35 -5.82 -0.31 1.4e-8 Gout;Renal underexcretion gout; CRC cis rs6545883 0.894 rs1186703 chr2:61672965 A/C cg15711740 chr2:61764176 XPO1 -0.44 -5.8 -0.3 1.6e-8 Tuberculosis; CRC cis rs7312933 0.737 rs10880261 chr12:42573822 T/C cg11827402 chr12:42719852 PPHLN1;ZCRB1 0.65 9.03 0.45 1.51e-17 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CRC trans rs2727020 0.553 rs3862350 chr11:49595912 A/C cg03929089 chr4:120376271 NA -0.91 -16.26 -0.67 4.89e-44 Coronary artery disease; CRC cis rs2243480 1.000 rs35283677 chr7:65359233 C/T cg12463550 chr7:65579703 CRCP 0.71 6.53 0.34 2.52e-10 Diabetic kidney disease; CRC cis rs8177253 0.665 rs11921527 chr3:133441167 G/A cg11941060 chr3:133502564 NA -0.44 -7.22 -0.37 3.63e-12 Iron status biomarkers; CRC cis rs11585357 0.501 rs17458002 chr1:17591524 A/G cg08277548 chr1:17600880 PADI3 -0.63 -7.3 -0.37 2.16e-12 Hair shape; CRC cis rs7493 0.950 rs7785705 chr7:95033803 A/T cg21856205 chr7:94953877 PON1 -0.52 -6.67 -0.35 1.06e-10 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs10791323 0.559 rs10750549 chr11:133730820 A/G cg06766960 chr11:133703094 NA -0.38 -6.28 -0.33 1.1e-9 Childhood ear infection; CRC cis rs9872999 1 rs9872999 chr3:133457514 C/T cg17775713 chr3:133465469 TF 0.37 6.78 0.35 5.61e-11 Iron status biomarkers; CRC cis rs9894429 0.738 rs8077038 chr17:79577127 T/G cg21984481 chr17:79567631 NPLOC4 0.58 11.19 0.53 7.42e-25 Eye color traits; CRC trans rs459571 0.876 rs2520095 chr9:136919568 A/G cg09836344 chr4:1243392 C4orf42;CTBP1 -0.81 -11.47 -0.53 7.28e-26 Platelet distribution width; CRC cis rs736801 0.607 rs11746555 chr5:131727033 G/A cg21138405 chr5:131827807 IRF1 -0.35 -6.01 -0.31 5.06e-9 Breast cancer;Mosquito bite size; CRC cis rs939584 1.000 rs13401686 chr2:650519 A/G cg03610516 chr2:642275 NA -0.42 -5.84 -0.31 1.24e-8 Body mass index; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg18880390 chr1:175162128 KIAA0040 0.46 6.0 0.31 5.28e-9 Thyroid stimulating hormone; CRC cis rs34375054 0.526 rs2343638 chr12:125677122 G/C cg06287003 chr12:125626642 AACS -0.51 -7.05 -0.36 1.05e-11 Post bronchodilator FEV1/FVC ratio; CRC cis rs9467711 0.675 rs58825580 chr6:26365679 T/G cg16898833 chr6:26189333 HIST1H4D 0.69 6.42 0.33 4.82e-10 Autism spectrum disorder or schizophrenia; CRC trans rs2303319 0.504 rs16845945 chr2:162480684 C/T cg18122310 chr12:50236657 BCDIN3D -0.73 -6.11 -0.32 2.89e-9 Cognitive function; CRC cis rs1005277 0.505 rs10827835 chr10:38150709 G/A cg25517755 chr10:38738941 LOC399744 0.45 6.59 0.34 1.77e-10 Extrinsic epigenetic age acceleration; CRC cis rs7487075 0.820 rs7958774 chr12:46724668 A/G cg22049899 chr12:47219821 SLC38A4 0.34 6.18 0.32 1.91e-9 Itch intensity from mosquito bite; CRC cis rs854572 1.000 rs854572 chr7:94954696 C/G cg05342682 chr7:94953680 PON1 -0.57 -9.37 -0.46 1.21e-18 Paraoxonase activity; CRC cis rs2302190 0.882 rs9903050 chr17:56636908 T/C cg25885038 chr17:56607967 SEPT4 -0.51 -7.72 -0.39 1.44e-13 Vitamin D levels; CRC cis rs2535633 0.631 rs2710314 chr3:52969128 T/C cg07507251 chr3:52567010 NT5DC2 -0.37 -5.62 -0.3 4.09e-8 Body mass index; CRC cis rs1580019 0.885 rs4460269 chr7:32496445 T/C cg06627557 chr7:32535165 LSM5;AVL9 0.71 11.2 0.53 6.71e-25 Cognitive ability; CRC cis rs853679 0.882 rs9380069 chr6:28203300 A/G cg03623178 chr6:28175578 NA 0.7 5.94 0.31 7.06e-9 Depression; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg04246357 chr6:158589294 SERAC1;GTF2H5 -0.41 -6.44 -0.33 4.31e-10 Myopia (pathological); CRC cis rs6570726 0.526 rs9376934 chr6:145738702 A/G cg23711669 chr6:146136114 FBXO30 0.48 7.82 0.4 7.05e-14 Lobe attachment (rater-scored or self-reported); CRC cis rs6088580 0.634 rs11700221 chr20:32940320 T/C cg08999081 chr20:33150536 PIGU -0.65 -12.01 -0.55 8.26e-28 Glomerular filtration rate (creatinine); CRC cis rs10504229 1.000 rs66796009 chr8:58174529 G/A cg22535103 chr8:58192502 C8orf71 -0.82 -12.32 -0.56 5.95e-29 Developmental language disorder (linguistic errors); CRC cis rs2398893 0.924 rs7047684 chr9:96792790 C/T cg14459158 chr9:96720562 NA 0.39 6.49 0.34 3.18e-10 Waist-hip ratio;Waist-to-hip ratio adjusted for body mass index; CRC cis rs7786808 0.705 rs1377373 chr7:158215549 A/C cg17401720 chr7:158221031 PTPRN2 -0.38 -6.41 -0.33 5.06e-10 Obesity-related traits; CRC cis rs9372498 0.536 rs9481821 chr6:118846022 A/C cg15382696 chr6:118971807 C6orf204 0.6 7.89 0.4 4.57e-14 Diastolic blood pressure; CRC cis rs10911232 0.507 rs10911231 chr1:183051745 T/A ch.1.3577855R chr1:183094577 LAMC1 0.82 14.22 0.62 4.28e-36 Hypertriglyceridemia; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg06434972 chr7:44122219 POLM 0.45 6.33 0.33 7.87e-10 Response to antipsychotic treatment; CRC cis rs875971 0.545 rs316316 chr7:65614257 C/T cg18876405 chr7:65276391 NA -0.44 -6.17 -0.32 2.05e-9 Aortic root size; CRC cis rs9296736 0.890 rs9637973 chr6:53903152 C/T cg04374786 chr6:53939321 C6orf142 0.47 7.43 0.38 9.5e-13 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs7847628 0.587 rs4837796 chr9:123610288 A/G cg09586646 chr9:123605570 PSMD5;LOC253039 -0.84 -14.86 -0.63 1.41e-38 Birth weight; CRC cis rs1552244 1.000 rs6807846 chr3:10134491 G/T cg16606324 chr3:10149918 C3orf24 0.69 9.58 0.47 2.45e-19 Alzheimer's disease; CRC trans rs877282 1.000 rs11253367 chr10:773389 G/A cg22713356 chr15:30763199 NA 1.14 14.82 0.63 2.06e-38 Uric acid levels; CRC cis rs2153535 0.505 rs1737583 chr6:8536812 G/A cg07606381 chr6:8435919 SLC35B3 0.68 11.17 0.52 9.04e-25 Motion sickness; CRC cis rs2243480 1.000 rs781150 chr7:65480973 C/T cg18252515 chr7:66147081 NA -1.14 -12.55 -0.57 8.83e-30 Diabetic kidney disease; CRC trans rs3213758 0.588 rs78389273 chr16:53563813 G/C cg18584265 chr19:15219983 SYDE1 0.65 6.47 0.34 3.59e-10 Vitiligo (non-segmental); CRC cis rs12291225 0.545 rs11023187 chr11:14345559 T/G cg05501817 chr11:14380813 RRAS2 -0.47 -6.5 -0.34 2.97e-10 Sense of smell; CRC cis rs6504950 0.720 rs9914836 chr17:52997875 C/G cg26251398 chr17:52985966 TOM1L1 0.4 5.77 0.3 1.87e-8 Breast cancer; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg25608973 chr2:21022431 C2orf43 0.44 6.32 0.33 8.46e-10 Intelligence (multi-trait analysis); CRC cis rs9611565 0.512 rs964898 chr22:42142306 C/T cg06481639 chr22:41940642 POLR3H -0.53 -6.03 -0.32 4.34e-9 Vitiligo; CRC cis rs2066819 1.000 rs17118409 chr12:56630764 G/A cg26714650 chr12:56694279 CS -1.42 -11.61 -0.54 2.3e-26 Psoriasis vulgaris; CRC cis rs4731207 0.662 rs6466950 chr7:124453074 G/C cg23710748 chr7:124431027 NA 0.38 6.08 0.32 3.42e-9 Cutaneous malignant melanoma; CRC cis rs4285028 0.699 rs1574115 chr3:121469225 T/C cg11130432 chr3:121712080 ILDR1 -0.51 -6.06 -0.32 3.75e-9 Multiple sclerosis; CRC cis rs8180040 0.966 rs6790763 chr3:47572585 C/A cg27129171 chr3:47204927 SETD2 0.53 8.15 0.41 7.69e-15 Colorectal cancer; CRC cis rs910316 0.737 rs424120 chr14:75482828 G/T cg11812906 chr14:75593930 NEK9 -0.57 -8.6 -0.43 3.23e-16 Height; CRC trans rs61931739 0.534 rs11053014 chr12:34103519 G/A cg26384229 chr12:38710491 ALG10B 0.54 6.95 0.36 1.99e-11 Morning vs. evening chronotype; CRC cis rs9487051 1.000 rs11757567 chr6:109614713 G/A cg01475377 chr6:109611718 NA -0.45 -7.98 -0.4 2.39e-14 Reticulocyte fraction of red cells; CRC trans rs9630182 0.561 rs10832038 chr11:13472254 G/C cg13741668 chr9:85679694 NA 0.38 6.19 0.32 1.79e-9 Bone mineral density; CRC trans rs11343 0.675 rs7359333 chr16:19262344 A/T cg06314568 chr15:52043507 LYSMD2;TMOD2 -0.45 -6.97 -0.36 1.73e-11 Parkinson's disease; CRC cis rs2070997 0.702 rs2227985 chr9:133755528 A/G cg01000188 chr9:133769184 QRFP 0.56 5.65 0.3 3.5e-8 Response to amphetamines; CRC cis rs9467603 1.000 rs9467609 chr6:25809751 A/G cg08501292 chr6:25962987 TRIM38 1.08 9.37 0.46 1.19e-18 Intelligence (multi-trait analysis); CRC cis rs3091242 0.933 rs34006994 chr1:25780668 C/T cg23205692 chr1:25664452 TMEM50A -0.4 -5.67 -0.3 3.13e-8 Erythrocyte sedimentation rate; CRC trans rs7800418 0.723 rs56156003 chr7:26590737 G/T cg14387656 chr2:233470847 EFHD1 0.47 6.43 0.33 4.6e-10 Cognitive function; CRC cis rs2836974 0.602 rs2037925 chr21:40699931 C/T cg06238570 chr21:40685208 BRWD1 -0.79 -12.49 -0.57 1.48e-29 Cognitive function; CRC trans rs8108034 1.000 rs39587 chr19:39806997 C/T cg07404363 chr5:112197029 SRP19 -0.58 -6.36 -0.33 6.92e-10 Lung adenocarcinoma; CRC trans rs7618501 1.000 rs7372725 chr3:49790544 C/A cg21582582 chr3:182698605 DCUN1D1 -0.56 -8.08 -0.41 1.22e-14 Intelligence (multi-trait analysis); CRC cis rs62064224 0.589 rs2344976 chr17:30685935 T/C cg18200150 chr17:30822561 MYO1D 0.45 8.74 0.43 1.24e-16 Schizophrenia; CRC cis rs7527798 0.592 rs11118359 chr1:207858546 T/C cg09232269 chr1:207846808 CR1L -0.45 -7.32 -0.37 1.88e-12 Erythrocyte sedimentation rate; CRC cis rs7177699 0.581 rs7165081 chr15:79123396 C/G cg15571903 chr15:79123663 NA 0.34 6.92 0.36 2.4e-11 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; CRC cis rs1065656 0.553 rs344360 chr16:1839221 T/C cg09830162 chr16:1889614 FAHD1;C16orf73 0.57 6.97 0.36 1.79e-11 Insulin-like growth factors; CRC cis rs4665809 0.590 rs2033317 chr2:26477650 G/A cg25036284 chr2:26402008 FAM59B 0.64 8.53 0.43 5.5e-16 Gut microbiome composition (summer); CRC cis rs4862750 0.837 rs1863404 chr4:187874654 T/C cg06074448 chr4:187884817 NA -0.58 -10.91 -0.52 7.21e-24 Lobe attachment (rater-scored or self-reported); CRC cis rs6502050 0.835 rs8071737 chr17:80117537 T/C cg11859384 chr17:80120422 CCDC57 -0.37 -5.98 -0.31 5.86e-9 Life satisfaction; CRC cis rs1124376 1.000 rs11712709 chr3:20139777 G/C cg05072819 chr3:20081367 KAT2B 0.54 6.27 0.33 1.15e-9 Bipolar disorder and schizophrenia; CRC cis rs2243480 1.000 rs1499613 chr7:65730860 G/A cg12463550 chr7:65579703 CRCP -0.68 -6.07 -0.32 3.43e-9 Diabetic kidney disease; CRC cis rs9788721 0.806 rs4887056 chr15:78734585 A/G cg18825076 chr15:78729989 IREB2 -0.47 -7.22 -0.37 3.69e-12 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio;Emphysema imaging phenotypes;Emphysema distribution in smoking;Local histogram emphysema pattern;Post bronchodilator FEV1/FVC ratio in COPD; CRC trans rs875971 0.660 rs2191268 chr7:66110224 C/T cg07931783 chr6:49431133 CENPQ;MUT -0.4 -6.32 -0.33 8.58e-10 Aortic root size; CRC cis rs3772130 0.926 rs13072767 chr3:121504098 A/G cg20356878 chr3:121714668 ILDR1 0.51 8.03 0.4 1.74e-14 Cognitive performance; CRC cis rs7945705 1.000 rs7937298 chr11:8867509 G/C cg12365402 chr11:9010492 NRIP3 0.46 7.21 0.37 3.79e-12 Hemoglobin concentration; CRC cis rs7412746 0.646 rs10399947 chr1:150861960 G/A cg15448220 chr1:150897856 SETDB1 0.49 7.22 0.37 3.65e-12 Melanoma; CRC cis rs7255436 0.965 rs12981318 chr19:8451430 G/A cg16745616 chr19:8428856 ANGPTL4 -0.45 -7.04 -0.36 1.16e-11 HDL cholesterol; CRC cis rs7618501 0.633 rs4688690 chr3:50022292 G/A cg05623727 chr3:50126028 RBM5 0.46 7.69 0.39 1.76e-13 Intelligence (multi-trait analysis); CRC cis rs11123170 0.640 rs2863240 chr2:113970116 C/T cg21550016 chr2:113992930 PAX8;LOC440839;LOC654433 -0.59 -7.91 -0.4 3.83e-14 Renal function-related traits (BUN); CRC cis rs6545883 0.525 rs1729662 chr2:61391305 G/A cg10580144 chr2:61372316 C2orf74 0.28 5.75 0.3 2.07e-8 Tuberculosis; CRC trans rs7395662 0.818 rs34486360 chr11:48782472 G/T cg21153622 chr11:89784906 NA -0.48 -7.7 -0.39 1.5700000000000001e-13 HDL cholesterol; CRC cis rs7666738 0.830 rs7672901 chr4:98938781 C/T cg17366294 chr4:99064904 C4orf37 0.43 7.35 0.38 1.63e-12 Colonoscopy-negative controls vs population controls; CRC cis rs7119 0.717 rs8033654 chr15:77825250 T/C cg10437265 chr15:77819839 NA 0.69 12.51 0.57 1.24e-29 Type 2 diabetes; CRC trans rs877282 1.000 rs11253362 chr10:770979 G/T cg22713356 chr15:30763199 NA 1.33 16.72 0.68 7.48e-46 Uric acid levels; CRC cis rs6662572 0.906 rs11582058 chr1:46245423 A/G cg03123370 chr1:45965343 CCDC163P;MMACHC -0.47 -6.02 -0.32 4.61e-9 Blood protein levels; CRC cis rs7793239 0.550 rs10246191 chr7:130029811 G/A cg03229158 chr7:130009420 NA 0.4 5.65 0.3 3.39e-8 Antipsychotic drug-induced QTc interval change in schizophrenia; CRC cis rs1018836 0.828 rs10091275 chr8:91559751 A/G cg16814680 chr8:91681699 NA -0.61 -9.38 -0.46 1.15e-18 Ejection fraction in Tripanosoma cruzi seropositivity; CRC cis rs6684514 1.000 rs12041164 chr1:156279811 G/A cg16558208 chr1:156270281 VHLL 0.56 8.8 0.44 7.83e-17 Mean corpuscular hemoglobin concentration;Glycated hemoglobin levels; CRC trans rs10411161 0.702 rs7251689 chr19:52389117 A/T cg22319618 chr22:45562946 NUP50 -0.65 -7.24 -0.37 3.26e-12 Breast cancer; CRC cis rs4900538 0.855 rs762105 chr14:102830175 A/G cg18135206 chr14:102964638 TECPR2 -0.98 -17.76 -0.7 5.6e-50 Mean corpuscular volume;Mean corpuscular hemoglobin; CRC cis rs2274273 0.806 rs7146752 chr14:55738907 A/G cg23234261 chr14:55582407 NA -0.29 -5.74 -0.3 2.19e-8 Protein biomarker; CRC cis rs1728785 0.786 rs1728770 chr16:68564124 G/C cg02972257 chr16:68554789 NA -0.62 -7.08 -0.36 8.68e-12 Ulcerative colitis; CRC cis rs6570726 0.935 rs452552 chr6:145820781 G/A cg23711669 chr6:146136114 FBXO30 0.68 12.16 0.56 2.33e-28 Lobe attachment (rater-scored or self-reported); CRC cis rs6460942 0.915 rs62447639 chr7:12486803 T/C cg06484146 chr7:12443880 VWDE -0.77 -7.99 -0.4 2.25e-14 Coronary artery disease; CRC cis rs2304069 0.565 rs13183261 chr5:149421847 T/G cg12661370 chr5:149340060 SLC26A2 0.42 6.09 0.32 3.21e-9 HIV-1 control; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg12909559 chr1:100435310 SLC35A3 0.37 6.12 0.32 2.68e-9 Liver disease severity in Alagille syndrome; CRC cis rs13256369 0.802 rs11249884 chr8:8561552 C/T cg00074818 chr8:8560427 CLDN23 -0.4 -7.19 -0.37 4.38e-12 Obesity-related traits; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg16326998 chr7:5553266 FBXL18 0.45 7.42 0.38 1.03e-12 Liver disease severity in Alagille syndrome; CRC cis rs11098499 0.909 rs79026312 chr4:120440677 C/A cg24375607 chr4:120327624 NA 0.47 7.13 0.37 6.55e-12 Corneal astigmatism; CRC cis rs7493 1.000 rs12026 chr7:95041016 G/C cg04155289 chr7:94953770 PON1 -0.6 -7.44 -0.38 8.8e-13 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs2952156 0.920 rs2517951 chr17:37853097 C/T cg11212589 chr17:38028394 ZPBP2 0.37 6.42 0.33 4.74e-10 Asthma; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg18500192 chr3:19189930 KCNH8 0.4 6.64 0.34 1.28e-10 Liver disease severity in Alagille syndrome; CRC cis rs6860806 0.507 rs274570 chr5:131713226 C/T cg18301423 chr5:131593218 PDLIM4 -0.38 -6.27 -0.33 1.14e-9 Breast cancer; CRC cis rs3812049 0.784 rs6889311 chr5:127431285 A/G cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.73 8.99 0.44 2.03e-17 Lymphocyte counts;Red cell distribution width; CRC cis rs1843834 0.611 rs1058360 chr2:225449242 A/T cg22455342 chr2:225449267 CUL3 0.7 9.41 0.46 8.92e-19 IgE levels in asthmatics (D.p. specific); CRC cis rs921968 0.565 rs3770220 chr2:219619550 C/T cg02176678 chr2:219576539 TTLL4 -0.39 -6.31 -0.33 8.83e-10 Mean corpuscular hemoglobin concentration; CRC cis rs2462686 1.000 rs2462686 chr7:45982460 A/G cg23193639 chr7:45961078 IGFBP3 -0.37 -5.72 -0.3 2.38e-8 Major depressive disorder; CRC cis rs1044826 0.692 rs188420 chr3:139233865 G/A cg00490450 chr3:139108681 COPB2 -0.43 -6.49 -0.34 3.11e-10 Obesity-related traits; CRC trans rs7615952 0.866 rs11922276 chr3:125631326 G/T cg16558177 chr4:4109446 NA -0.49 -5.99 -0.31 5.37e-9 Blood pressure (smoking interaction); CRC cis rs7113874 0.524 rs9734055 chr11:8577236 C/A cg17679104 chr11:8615758 STK33 -0.35 -5.86 -0.31 1.14e-8 Body mass index in physically active individuals;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs1568889 0.838 rs11030230 chr11:28174631 A/G cg06544937 chr11:28130018 METT5D1;KIF18A 0.92 15.3 0.64 2.69e-40 Bipolar disorder; CRC cis rs79387448 0.745 rs57942521 chr2:103139849 A/G cg09003973 chr2:102972529 NA 0.73 7.79 0.39 8.69e-14 Gut microbiota (bacterial taxa); CRC cis rs9467711 0.516 rs1324088 chr6:25841122 C/T cg08501292 chr6:25962987 TRIM38 0.61 6.75 0.35 6.68e-11 Autism spectrum disorder or schizophrenia; CRC cis rs8177253 1.000 rs8177252 chr3:133480174 C/A cg16262614 chr3:133464971 TF 0.32 5.78 0.3 1.76e-8 Iron status biomarkers; CRC cis rs6860806 0.507 rs272854 chr5:131688017 C/T cg27615366 chr5:131592974 PDLIM4 0.33 5.81 0.31 1.48e-8 Breast cancer; CRC cis rs6546324 0.514 rs2861639 chr2:67779919 G/C cg15745817 chr2:67799979 NA -0.5 -8.12 -0.41 9.7e-15 Endometriosis; CRC cis rs2204008 0.777 rs11179774 chr12:38219559 A/C cg13010199 chr12:38710504 ALG10B 0.44 5.62 0.3 4.1e-8 Bladder cancer; CRC cis rs7552404 1.000 rs6593585 chr1:76140273 G/A cg03433033 chr1:76189801 ACADM 0.81 11.29 0.53 3.35e-25 Blood metabolite levels;Acylcarnitine levels; CRC cis rs6461049 0.519 rs3778992 chr7:2175313 C/G cg19897017 chr7:2163380 MAD1L1 0.39 6.19 0.32 1.78e-9 Schizophrenia; CRC cis rs45509595 0.822 rs200484 chr6:27775674 A/G cg03623178 chr6:28175578 NA 0.77 6.63 0.34 1.42e-10 Breast cancer; CRC cis rs7772486 0.686 rs857880 chr6:145971115 T/C cg23711669 chr6:146136114 FBXO30 -0.73 -12.42 -0.57 2.6e-29 Lobe attachment (rater-scored or self-reported); CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg09476286 chr2:26101366 ASXL2 0.47 6.45 0.34 4e-10 Anxiety disorder; CRC cis rs798554 1.000 rs798544 chr7:2763102 A/G cg04166393 chr7:2884313 GNA12 -0.47 -6.48 -0.34 3.31e-10 Height; CRC cis rs6960043 0.818 rs12699673 chr7:15049604 T/C cg19272540 chr7:15055459 NA 0.24 6.5 0.34 2.91e-10 Type 2 diabetes; CRC cis rs17125944 0.572 rs79312783 chr14:53250296 A/T cg00686598 chr14:53173677 PSMC6 1.17 10.76 0.51 2.43e-23 Alzheimer's disease (late onset); CRC cis rs860295 0.702 rs11264383 chr1:155545346 C/T cg02153340 chr1:155202674 NA -0.58 -6.75 -0.35 6.59e-11 Body mass index; CRC cis rs9291683 0.588 rs17246745 chr4:9994583 T/C cg11266682 chr4:10021025 SLC2A9 0.53 11.33 0.53 2.47e-25 Bone mineral density; CRC cis rs7677751 0.806 rs7682912 chr4:55085620 T/G cg00691999 chr4:55094011 PDGFRA 0.41 5.82 0.31 1.4e-8 Corneal astigmatism; CRC cis rs523522 0.923 rs3916065 chr12:120934624 A/C cg27279351 chr12:120934652 DYNLL1 0.79 11.6 0.54 2.58e-26 High light scatter reticulocyte count; CRC cis rs6540556 0.682 rs667681 chr1:209914449 A/G cg23920097 chr1:209922102 NA 0.51 5.84 0.31 1.22e-8 Red blood cell count; CRC cis rs172166 0.694 rs1631552 chr6:28089699 C/A cg02683197 chr6:28174875 NA 0.68 9.57 0.47 2.73e-19 Cardiac Troponin-T levels; CRC cis rs853679 0.517 rs36078605 chr6:28078032 A/C cg12172441 chr6:28176163 NA 0.61 7.18 0.37 4.72e-12 Depression; CRC cis rs12745968 0.620 rs6666831 chr1:93222797 C/A cg17283838 chr1:93427260 FAM69A -0.47 -6.43 -0.33 4.48e-10 Bipolar disorder and schizophrenia; CRC cis rs798502 0.541 rs2644307 chr7:2832973 G/A cg19346786 chr7:2764209 NA -0.32 -6.05 -0.32 3.87e-9 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Inflammatory bowel disease;Waist circumference adjusted for BMI in non-smokers;Ulcerative colitis;Waist circumference adjusted for body mass index;Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction); CRC cis rs6964587 1.000 rs13224513 chr7:91601465 G/A cg17063962 chr7:91808500 NA 0.81 14.19 0.62 5.71e-36 Breast cancer; CRC trans rs12478296 1.000 rs56136197 chr2:243043877 T/C cg18288967 chr1:45987694 PRDX1 0.68 7.43 0.38 9.51e-13 Obesity-related traits; CRC cis rs1801251 1.000 rs7587309 chr2:233705702 G/T cg25237894 chr2:233734115 C2orf82 -0.54 -8.77 -0.44 9.92e-17 Coronary artery disease; CRC cis rs6831352 0.734 rs2602856 chr4:100029145 C/A cg12011299 chr4:100065546 ADH4 0.49 10.27 0.49 1.19e-21 Alcohol dependence; CRC cis rs3825932 0.961 rs10400881 chr15:79234384 G/C cg25744700 chr15:79237217 CTSH 0.4 6.09 0.32 3.08e-9 Type 1 diabetes; CRC trans rs1945213 0.659 rs2086558 chr11:55844453 T/G cg03929089 chr4:120376271 NA 0.56 6.35 0.33 7.04e-10 Acute lymphoblastic leukemia (childhood); CRC cis rs6500395 0.775 rs13331298 chr16:48661489 G/A cg04672837 chr16:48644449 N4BP1 0.42 6.3 0.33 9.56e-10 Response to tocilizumab in rheumatoid arthritis; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg14433847 chr20:34329491 RBM39 0.42 6.28 0.33 1.09e-9 Liver disease severity in Alagille syndrome; CRC cis rs7927592 0.763 rs10896326 chr11:68234571 T/C cg16797656 chr11:68205561 LRP5 0.51 9.63 0.47 1.66e-19 Total body bone mineral density; CRC cis rs7605378 1.000 rs769958 chr2:200695901 G/A cg17644776 chr2:200775616 C2orf69 0.41 5.82 0.31 1.39e-8 Osteoporosis; CRC trans rs75246769 0.929 rs2030631 chr7:145504942 C/T cg14916917 chr5:81574294 RPS23 -0.82 -6.09 -0.32 3.24e-9 Facial morphology (factor 10, width of nasal floor); CRC cis rs1580019 0.961 rs958217 chr7:32493417 A/G cg07520158 chr7:32535189 LSM5;AVL9 0.45 6.46 0.34 3.7e-10 Cognitive ability; CRC cis rs7680126 0.644 rs4697703 chr4:10107431 A/G cg11266682 chr4:10021025 SLC2A9 -0.45 -6.81 -0.35 4.57e-11 Urate levels in lean individuals;Urate levels in overweight individuals;Urate levels in obese individuals; CRC cis rs4474465 0.833 rs10899540 chr11:78245549 T/A cg02023728 chr11:77925099 USP35 -0.37 -6.28 -0.33 1.09e-9 Alzheimer's disease (survival time); CRC cis rs4466137 0.830 rs6886695 chr5:82994293 T/A cg12199221 chr5:83017078 HAPLN1 -0.38 -5.85 -0.31 1.2e-8 Prostate cancer; CRC trans rs12310956 0.532 rs11052930 chr12:33964824 A/G cg26384229 chr12:38710491 ALG10B 0.51 6.46 0.34 3.87e-10 Morning vs. evening chronotype; CRC cis rs10504229 0.593 rs75047131 chr8:58001320 A/G cg02725872 chr8:58115012 NA -0.52 -7.31 -0.37 2.06e-12 Developmental language disorder (linguistic errors); CRC cis rs12472274 0.536 rs12619455 chr2:239080149 A/C cg17459225 chr2:239074497 NA 0.7 8.49 0.42 7.45e-16 Phospholipid levels (plasma); CRC cis rs2200578 1.000 rs72961173 chr2:99886868 G/A cg26064155 chr2:99771622 LIPT1;TSGA10 0.56 6.44 0.33 4.14e-10 IgG glycosylation; CRC trans rs13046373 0.905 rs4816372 chr21:32077414 A/T cg06764565 chr10:75910434 ADK;AP3M1 -0.44 -6.29 -0.33 9.98e-10 HDL cholesterol; CRC cis rs1707322 0.721 rs4559551 chr1:46167533 T/C cg03146154 chr1:46216737 IPP 0.68 9.91 0.48 1.95e-20 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs477895 0.713 rs882146 chr11:63976699 G/A cg05016508 chr11:63871570 FLRT1;MACROD1 0.55 6.87 0.35 3.16e-11 Mean platelet volume; CRC cis rs7618915 0.547 rs4130905 chr3:52709831 A/T cg18099408 chr3:52552593 STAB1 -0.44 -7.16 -0.37 5.27e-12 Bipolar disorder; CRC cis rs6964587 1.000 rs10228334 chr7:91713972 C/T cg17063962 chr7:91808500 NA 0.79 14.22 0.62 4.1e-36 Breast cancer; CRC trans rs2243480 0.908 rs313822 chr7:65573939 G/A cg10756647 chr7:56101905 PSPH 0.73 7.68 0.39 1.79e-13 Diabetic kidney disease; CRC cis rs1448094 0.511 rs10506923 chr12:86152595 C/T cg00310523 chr12:86230176 RASSF9 -0.38 -6.09 -0.32 3.19e-9 Major depressive disorder; CRC cis rs3996993 0.780 rs2290758 chr6:52662153 G/A cg20803780 chr6:52668592 GSTA1 -0.39 -7.21 -0.37 3.86e-12 Hemoglobin concentration; CRC trans rs2228479 0.850 rs1800344 chr16:89816367 T/G cg21302420 chr1:112162376 RAP1A 0.72 6.01 0.31 5.05e-9 Skin colour saturation; CRC cis rs9733 0.596 rs72700897 chr1:150626038 C/G cg15448220 chr1:150897856 SETDB1 0.45 6.43 0.33 4.42e-10 Tonsillectomy; CRC cis rs9372498 0.536 rs9489433 chr6:118867006 G/A cg01339444 chr6:118972232 C6orf204 0.53 6.03 0.32 4.29e-9 Diastolic blood pressure; CRC trans rs2303319 0.504 rs57464189 chr2:162419312 G/A cg09481857 chr22:21368659 P2RX6;MGC16703 -0.64 -6.1 -0.32 3.04e-9 Cognitive function; CRC cis rs9549367 0.713 rs9577211 chr13:113830718 G/C cg18105134 chr13:113819100 PROZ -0.87 -13.31 -0.59 1.27e-32 Platelet distribution width; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg17287814 chr8:26149013 PPP2R2A 0.44 6.41 0.33 5.17e-10 Response to antipsychotic treatment; CRC cis rs9807989 0.507 rs1592458 chr2:103031749 A/T cg03938978 chr2:103052716 IL18RAP 0.59 10.13 0.49 3.5e-21 Asthma; CRC cis rs2153535 0.505 rs1737583 chr6:8536812 G/A cg21535247 chr6:8435926 SLC35B3 0.51 7.88 0.4 4.82e-14 Motion sickness; CRC cis rs9649213 0.574 rs34717219 chr7:97962271 A/C cg00277769 chr7:97922759 BAIAP2L1 -0.6 -10.46 -0.5 2.77e-22 Prostate cancer (SNP x SNP interaction); CRC cis rs12760731 0.720 rs10753178 chr1:178401000 A/T cg00404053 chr1:178313656 RASAL2 0.87 10.32 0.49 7.87e-22 Obesity-related traits; CRC cis rs6740322 0.895 rs6744746 chr2:43555805 A/C cg06169590 chr2:43455088 ZFP36L2;LOC100129726 0.58 7.18 0.37 4.54e-12 Coronary artery disease; CRC cis rs4713118 0.662 rs149961 chr6:28015569 A/C cg03623178 chr6:28175578 NA 0.88 12.63 0.57 4.53e-30 Parkinson's disease; CRC cis rs2576037 0.583 rs530205 chr18:44385150 C/T cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.55 -8.33 -0.42 2.24e-15 Personality dimensions; CRC cis rs8180040 0.966 rs57346147 chr3:47410564 C/G cg10298567 chr3:47292165 KIF9 0.38 6.06 0.32 3.71e-9 Colorectal cancer; CRC cis rs769267 0.965 rs2074550 chr19:19387743 A/C cg03709012 chr19:19516395 GATAD2A 0.71 10.91 0.52 7.13e-24 Tonsillectomy; CRC cis rs10256972 0.706 rs12701969 chr7:1121849 A/G cg04025307 chr7:1156635 C7orf50 0.7 10.75 0.51 2.57e-23 Longevity;Endometriosis; CRC cis rs1707322 0.928 rs61785614 chr1:46446047 A/G cg06784218 chr1:46089804 CCDC17 0.51 8.96 0.44 2.39e-17 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC trans rs8123881 0.733 rs7268466 chr20:15810676 C/T cg23506944 chr17:28257236 EFCAB5;SSH2 0.62 6.99 0.36 1.49e-11 Body mass index; CRC cis rs727479 0.502 rs4775932 chr15:51498539 A/G cg19946085 chr15:51559439 CYP19A1 -0.29 -5.86 -0.31 1.15e-8 Estradiol levels; CRC cis rs2760061 0.819 rs708112 chr1:228192452 G/A cg02753203 chr1:228287806 NA 0.68 10.44 0.5 3.19e-22 Diastolic blood pressure; CRC cis rs7259376 0.645 rs7245650 chr19:22483695 A/G cg02657401 chr19:22469223 NA -0.3 -6.88 -0.35 3.09e-11 Menopause (age at onset); CRC cis rs9300255 0.544 rs1790123 chr12:123659542 C/T cg00376283 chr12:123451042 ABCB9 0.52 6.31 0.33 8.81e-10 Neutrophil percentage of white cells; CRC cis rs561341 0.714 rs474455 chr17:30312465 A/T cg23018236 chr17:30244563 NA -0.58 -7.79 -0.39 9.07e-14 Hip circumference adjusted for BMI; CRC cis rs10256972 0.567 rs7782651 chr7:1159895 T/G cg18765753 chr7:1198926 ZFAND2A -0.39 -6.6 -0.34 1.65e-10 Longevity;Endometriosis; CRC cis rs9908102 0.740 rs8078394 chr17:12910602 C/T cg26162695 chr17:12921313 ELAC2 0.43 5.85 0.31 1.17e-8 Schizophrenia; CRC trans rs8123881 0.733 rs7268466 chr20:15810676 C/T cg20444381 chr8:109456000 TTC35 0.61 6.64 0.34 1.3100000000000001e-10 Body mass index; CRC cis rs6460942 0.778 rs74993124 chr7:12462917 A/G cg06484146 chr7:12443880 VWDE -0.69 -8.6 -0.43 3.24e-16 Coronary artery disease; CRC cis rs8062405 0.964 rs78613234 chr16:28839425 T/C cg16576597 chr16:28551801 NUPR1 0.48 6.89 0.35 2.93e-11 Cognitive ability (multi-trait analysis);Cognitive ability; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg15356674 chr10:79471309 NA 0.42 6.2 0.32 1.69e-9 Response to antipsychotic treatment; CRC cis rs7737355 0.738 rs3776001 chr5:130957992 T/A cg25547332 chr5:131281432 NA 0.37 5.8 0.3 1.53e-8 Life satisfaction; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg25259117 chr17:49337500 MBTD1;UTP18 0.39 6.21 0.32 1.58e-9 Liver disease severity in Alagille syndrome; CRC trans rs7937682 0.961 rs11828343 chr11:111491322 A/G cg18187862 chr3:45730750 SACM1L -0.51 -6.93 -0.36 2.18e-11 Primary sclerosing cholangitis; CRC cis rs965469 0.895 rs6037595 chr20:3401128 T/G cg25506879 chr20:3388711 C20orf194 -0.4 -6.2 -0.32 1.69e-9 IFN-related cytopenia; CRC cis rs317865 0.737 rs55949632 chr4:16207072 T/C cg04764131 chr4:16228633 TAPT1;FLJ39653 0.64 5.77 0.3 1.88e-8 Kidney disease (early stage) in type 1 diabetes; CRC cis rs8072100 0.640 rs3851808 chr17:45425144 C/T cg25173405 chr17:45401733 C17orf57 -0.47 -7.24 -0.37 3.22e-12 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs6456156 0.967 rs150108 chr6:167513153 C/T cg07513332 chr6:167530253 CCR6 0.39 6.89 0.35 2.92e-11 Primary biliary cholangitis; CRC trans rs7615952 0.546 rs2922194 chr3:125332263 G/A cg07211511 chr3:129823064 LOC729375 -0.62 -7.01 -0.36 1.33e-11 Blood pressure (smoking interaction); CRC cis rs7917772 0.636 rs4919676 chr10:104524352 C/T cg04362960 chr10:104952993 NT5C2 0.46 6.18 0.32 1.85e-9 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC cis rs11792861 0.855 rs72607165 chr9:111814498 C/T cg05043794 chr9:111880884 C9orf5 -0.37 -6.57 -0.34 2e-10 Menarche (age at onset); CRC cis rs2075371 0.933 rs1833475 chr7:133958263 C/T cg02659138 chr7:134003124 SLC35B4 0.36 6.24 0.33 1.33e-9 Mean platelet volume; CRC cis rs883565 0.502 rs11129810 chr3:38946064 C/T cg01426195 chr3:39028469 NA -0.37 -6.23 -0.32 1.42e-9 Handedness; CRC cis rs9467773 0.549 rs9467805 chr6:26583366 C/T cg09904177 chr6:26538194 HMGN4 0.72 11.32 0.53 2.6e-25 Intelligence (multi-trait analysis); CRC cis rs6424115 0.708 rs13551 chr1:24180962 T/C cg08896387 chr1:24191740 FUCA1 0.52 6.93 0.36 2.17e-11 Immature fraction of reticulocytes; CRC cis rs1223397 1.000 rs1223402 chr6:13271640 G/A cg07912922 chr6:13274314 PHACTR1 0.5 6.12 0.32 2.68e-9 Blood pressure; CRC cis rs9916302 0.706 rs8182252 chr17:37727950 T/C cg03013999 chr17:37608204 MED1 -0.43 -5.78 -0.3 1.71e-8 Glomerular filtration rate (creatinine); CRC cis rs79839061 0.666 rs62297063 chr4:869708 G/A cg07828340 chr4:882639 GAK 1.12 10.91 0.52 7.06e-24 Intelligence (multi-trait analysis); CRC cis rs6500602 0.673 rs4786512 chr16:4573040 A/G cg14951292 chr16:4525986 HMOX2;NMRAL1 0.61 8.52 0.43 5.79e-16 Schizophrenia; CRC cis rs10754283 0.967 rs10801757 chr1:90103080 A/G cg21401794 chr1:90099060 LRRC8C 0.39 5.79 0.3 1.65e-8 Amyotrophic lateral sclerosis (sporadic); CRC cis rs7591163 1.000 rs4487084 chr2:228713179 G/A cg00063174 chr2:228736253 WDR69 -0.51 -6.86 -0.35 3.49e-11 Blood pressure; CRC cis rs9300255 0.722 rs12304248 chr12:123810425 C/T cg00376283 chr12:123451042 ABCB9 -0.55 -7.22 -0.37 3.54e-12 Neutrophil percentage of white cells; CRC cis rs2836974 0.627 rs8127986 chr21:40687211 A/T cg22974920 chr21:40686053 BRWD1 -0.41 -5.64 -0.3 3.64e-8 Cognitive function; CRC cis rs858239 0.899 rs2268745 chr7:23317600 G/A cg00469287 chr7:23338798 C7orf30 0.48 6.1 0.32 2.98e-9 Cerebrospinal fluid biomarker levels; CRC cis rs9467773 1.000 rs4713008 chr6:26538268 T/C cg09904177 chr6:26538194 HMGN4 0.86 14.87 0.63 1.27e-38 Intelligence (multi-trait analysis); CRC cis rs60871478 0.945 rs62432254 chr7:804175 C/T cg04727924 chr7:799746 HEATR2 -0.45 -6.77 -0.35 6e-11 Cerebrospinal P-tau181p levels; CRC trans rs1728785 0.901 rs11865339 chr16:68565296 C/T cg04657470 chr2:198365150 HSPE1;HSPD1 0.57 6.78 0.35 5.72e-11 Ulcerative colitis; CRC cis rs7945705 0.967 rs10769973 chr11:8928615 C/G cg14711859 chr11:8959438 ASCL3 -0.5 -7.97 -0.4 2.58e-14 Hemoglobin concentration; CRC cis rs826838 1.000 rs860400 chr12:39081279 A/G cg13010199 chr12:38710504 ALG10B -0.43 -6.21 -0.32 1.57e-9 Heart rate; CRC cis rs904251 0.861 rs1757183 chr6:37484790 C/T cg25019722 chr6:37503610 NA 0.46 8.34 0.42 2.09e-15 Cognitive performance; CRC cis rs155076 1.000 rs261432 chr13:21865915 G/C cg25811766 chr13:21894605 NA -0.56 -6.13 -0.32 2.56e-9 White matter hyperintensity burden; CRC cis rs3785574 0.962 rs2665842 chr17:61878535 G/A cg06873352 chr17:61820015 STRADA 0.5 8.13 0.41 8.85e-15 Height; CRC cis rs908922 0.676 rs7550769 chr1:152531213 G/A cg23254163 chr1:152506842 NA 0.45 9.15 0.45 6.31e-18 Hair morphology; CRC cis rs7666738 0.887 rs34509663 chr4:98982531 C/T cg17366294 chr4:99064904 C4orf37 0.45 7.31 0.37 2.08e-12 Colonoscopy-negative controls vs population controls; CRC cis rs9649213 0.574 rs7802560 chr7:97903806 A/G cg24562669 chr7:97807699 LMTK2 -0.42 -7.32 -0.37 1.9e-12 Prostate cancer (SNP x SNP interaction); CRC cis rs6998277 1.000 rs4734648 chr8:103635994 G/A cg10187029 chr8:103597600 NA 0.91 12.29 0.56 8.03e-29 Migraine; CRC cis rs12908161 0.959 rs1051168 chr15:85200520 G/T cg11189052 chr15:85197271 WDR73 0.64 9.04 0.45 1.39e-17 Schizophrenia; CRC trans rs7937682 0.855 rs7109592 chr11:111533105 C/A cg18187862 chr3:45730750 SACM1L 0.46 6.74 0.35 7.28e-11 Primary sclerosing cholangitis; CRC cis rs2227564 0.620 rs4746148 chr10:75534488 C/T cg00564723 chr10:75632066 CAMK2G -0.31 -7.45 -0.38 8.41e-13 Crohn's disease;Inflammatory bowel disease; CRC cis rs2243480 1.000 rs186378 chr7:65582058 A/C cg12463550 chr7:65579703 CRCP 0.66 6.15 0.32 2.28e-9 Diabetic kidney disease; CRC cis rs10256972 0.732 rs1574108 chr7:1105805 T/C cg07308232 chr7:1071921 C7orf50 -0.48 -6.59 -0.34 1.72e-10 Longevity;Endometriosis; CRC cis rs2836950 0.545 rs4818001 chr21:40575088 T/C cg06238570 chr21:40685208 BRWD1 -0.63 -9.18 -0.45 4.94e-18 Menarche (age at onset); CRC cis rs853679 0.546 rs493161 chr6:27850714 A/T cg19041857 chr6:27730383 NA -0.76 -7.08 -0.36 8.75e-12 Depression; CRC cis rs7666738 0.830 rs34135615 chr4:99001325 C/T cg05340658 chr4:99064831 C4orf37 0.61 9.54 0.47 3.44e-19 Colonoscopy-negative controls vs population controls; CRC trans rs6076960 0.684 rs3844461 chr20:6253115 G/A cg17788362 chr6:86352627 SYNCRIP 0.54 7.53 0.38 5.06e-13 Smooth-surface caries; CRC cis rs6961069 0.777 rs2366855 chr7:80253455 A/T cg04458919 chr7:80252533 CD36 -0.33 -5.82 -0.31 1.37e-8 Platelet count; CRC cis rs736801 0.569 rs12517950 chr5:131731326 A/G cg07395648 chr5:131743802 NA -0.4 -5.96 -0.31 6.33e-9 Breast cancer;Mosquito bite size; CRC cis rs10883723 0.810 rs61873733 chr10:104251458 G/A cg11453585 chr10:104263688 ACTR1A;SUFU 0.92 17.47 0.69 8.01e-49 Allergic disease (asthma, hay fever or eczema); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg05307908 chr4:37687729 RELL1 0.43 6.0 0.31 5.16e-9 Response to antipsychotic treatment; CRC trans rs7267979 0.932 rs928121 chr20:25534818 A/G cg17903999 chr18:56338584 MALT1 -0.43 -7.18 -0.37 4.65e-12 Liver enzyme levels (alkaline phosphatase); CRC cis rs2836950 0.509 rs4816618 chr21:40599529 G/A cg06238570 chr21:40685208 BRWD1 -0.6 -8.72 -0.43 1.42e-16 Menarche (age at onset); CRC cis rs6062302 0.522 rs4809312 chr20:62234240 C/T cg06363034 chr20:62225388 GMEB2 -0.44 -6.56 -0.34 2.15e-10 Glioblastoma; CRC cis rs9916302 0.861 rs752314 chr17:37410700 C/T cg03013999 chr17:37608204 MED1 0.48 7.57 0.39 3.75e-13 Glomerular filtration rate (creatinine); CRC trans rs9858542 0.953 rs67216675 chr3:49493151 G/T cg21582582 chr3:182698605 DCUN1D1 -0.51 -6.45 -0.34 4.03e-10 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs7589728 0.620 rs76687350 chr2:88473832 G/A cg14558114 chr2:88469736 THNSL2 0.57 5.67 0.3 3.21e-8 Plasma clusterin levels; CRC cis rs6570726 0.846 rs371186 chr6:145886971 T/C cg23711669 chr6:146136114 FBXO30 0.67 11.33 0.53 2.35e-25 Lobe attachment (rater-scored or self-reported); CRC cis rs10504229 0.683 rs55714371 chr8:58131846 T/G cg22535103 chr8:58192502 C8orf71 -0.7 -9.34 -0.46 1.47e-18 Developmental language disorder (linguistic errors); CRC cis rs12580194 1.000 rs12582022 chr12:55694360 A/G cg19537932 chr12:55886519 OR6C68 -0.53 -6.69 -0.35 9.76e-11 Cancer; CRC cis rs1448094 0.511 rs10863079 chr12:86152700 T/A cg19622623 chr12:86230825 RASSF9 0.38 5.81 0.31 1.46e-8 Major depressive disorder; CRC cis rs11098499 0.865 rs4001305 chr4:120359236 G/T cg09307838 chr4:120376055 NA 0.72 11.08 0.52 1.91e-24 Corneal astigmatism; CRC cis rs1816752 0.905 rs8002215 chr13:24990367 A/G cg02811702 chr13:24901961 NA 0.41 5.74 0.3 2.13e-8 Obesity-related traits; CRC cis rs6908034 0.505 rs77880623 chr6:19819454 T/C cg02682789 chr6:19804855 NA 0.83 6.67 0.35 1.08e-10 Endometriosis;Deep ovarian and/or rectovaginal disease with dense adhesions; CRC cis rs72781680 0.800 rs56398785 chr2:24091515 T/A cg08917208 chr2:24149416 ATAD2B 1.04 10.12 0.49 3.79e-21 Lymphocyte counts; CRC cis rs909002 0.800 rs3753613 chr1:32082000 C/T cg13919466 chr1:32135498 COL16A1 0.31 5.88 0.31 1e-8 Intelligence (multi-trait analysis); CRC cis rs10504229 1.000 rs60231757 chr8:58169937 T/C cg05313129 chr8:58192883 C8orf71 -0.47 -6.99 -0.36 1.49e-11 Developmental language disorder (linguistic errors); CRC trans rs9929218 0.954 rs9925923 chr16:68819614 C/T cg04657470 chr2:198365150 HSPE1;HSPD1 -0.81 -11.68 -0.54 1.29e-26 Colorectal cancer; CRC cis rs13108904 0.967 rs12502916 chr4:1276349 G/A cg02018176 chr4:1364513 KIAA1530 -0.49 -8.32 -0.42 2.42e-15 Obesity-related traits; CRC cis rs4604732 0.527 rs79329288 chr1:247626513 T/C cg02104434 chr1:247694406 LOC148824;OR2C3 0.6 8.82 0.44 6.67e-17 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CRC cis rs10504229 0.639 rs2318146 chr8:58114873 T/G cg21724239 chr8:58056113 NA 0.49 6.77 0.35 5.94e-11 Developmental language disorder (linguistic errors); CRC cis rs8105895 0.935 rs1560717 chr19:22292247 A/G cg02912127 chr19:22235281 ZNF257 -0.43 -5.86 -0.31 1.15e-8 Body mass index (change over time); CRC cis rs3806843 0.676 rs753280 chr5:140024042 C/T cg19875535 chr5:140030758 IK 0.63 10.99 0.52 3.71e-24 Depressive symptoms (multi-trait analysis); CRC cis rs9942416 0.592 rs10462521 chr5:74985867 T/C cg00601450 chr5:74908170 NA 0.42 5.81 0.31 1.46e-8 Age-related disease endophenotypes; CRC cis rs763014 1.000 rs7205409 chr16:642610 A/G cg04497992 chr16:616212 NHLRC4 0.4 6.54 0.34 2.29e-10 Height; CRC cis rs2882667 0.690 rs288022 chr5:138224275 A/C cg09476006 chr5:138032270 NA 0.57 10.13 0.49 3.47e-21 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs11608355 0.597 rs12579285 chr12:109832712 T/C cg19025524 chr12:109796872 NA -0.57 -9.38 -0.46 1.09e-18 Neuroticism; CRC cis rs2985684 0.846 rs11157693 chr14:50048426 T/C cg04989706 chr14:50066350 PPIL5 -0.62 -8.8 -0.44 8.02e-17 Carotid intima media thickness; CRC cis rs4332037 0.539 rs55988458 chr7:2059761 G/A cg23378565 chr7:2036160 MAD1L1 -0.43 -6.09 -0.32 3.16e-9 Bipolar disorder; CRC cis rs875971 0.862 rs2460432 chr7:65554385 C/T cg00343986 chr7:65444356 GUSB -0.44 -6.3 -0.33 9.42e-10 Aortic root size; CRC cis rs6426558 0.559 rs2813947 chr1:227459413 G/T cg10327440 chr1:227177885 CDC42BPA 0.43 6.37 0.33 6.42e-10 Neutrophil percentage of white cells; CRC cis rs11212617 0.875 rs10789659 chr11:108255828 C/T cg01991180 chr11:108092276 ATM;NPAT 0.44 6.37 0.33 6.42e-10 Response to metformin in type 2 diabetes (glycemic); CRC cis rs4285028 0.747 rs7648343 chr3:121426195 G/A cg20356878 chr3:121714668 ILDR1 -0.48 -6.4 -0.33 5.39e-10 Multiple sclerosis; CRC cis rs6496667 0.817 rs74528922 chr15:90921009 T/C cg04176472 chr15:90893244 GABARAPL3 0.6 7.88 0.4 4.77e-14 Rheumatoid arthritis; CRC cis rs6570726 0.791 rs6570694 chr6:145911204 C/G cg23711669 chr6:146136114 FBXO30 0.68 11.28 0.53 3.51e-25 Lobe attachment (rater-scored or self-reported); CRC cis rs6502050 0.731 rs76421195 chr17:80109326 T/C cg02741985 chr17:80059408 CCDC57 0.43 7.15 0.37 5.66e-12 Life satisfaction; CRC cis rs908922 0.651 rs548252 chr1:152489742 A/G cg23254163 chr1:152506842 NA -0.5 -10.05 -0.48 6.73e-21 Hair morphology; CRC cis rs59918340 0.764 rs10101692 chr8:142230823 C/T cg17298326 chr8:142245477 NA -0.38 -5.7 -0.3 2.63e-8 Immature fraction of reticulocytes; CRC cis rs2303759 0.918 rs8107548 chr19:49870643 T/C cg22590775 chr19:49891494 CCDC155 0.66 9.34 0.46 1.55e-18 Multiple sclerosis; CRC cis rs6952808 0.543 rs4719436 chr7:2141239 G/A cg21782813 chr7:2030301 MAD1L1 0.54 9.51 0.46 4.07e-19 Bipolar disorder and schizophrenia; CRC cis rs798554 1.000 rs798550 chr7:2760609 A/G cg14895029 chr7:2775587 GNA12 -0.39 -5.97 -0.31 6.27e-9 Height; CRC cis rs7945718 0.967 rs11022490 chr11:12773526 C/G cg25843174 chr11:12811716 TEAD1 -0.49 -9.2 -0.45 4.28e-18 Educational attainment (years of education); CRC trans rs916888 0.773 rs199448 chr17:44809001 A/G cg23590916 chr17:43697445 MGC57346 0.7 7.16 0.37 5.21e-12 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC trans rs61931739 0.817 rs1705754 chr12:34145569 A/G cg26384229 chr12:38710491 ALG10B 0.44 6.25 0.33 1.29e-9 Morning vs. evening chronotype; CRC cis rs12913538 0.552 rs8037466 chr15:62910862 C/T cg09983546 chr15:62884068 NA -0.48 -7.5 -0.38 6.17e-13 Sleep depth; CRC cis rs11123170 0.640 rs1015754 chr2:113967990 T/C cg19083407 chr2:113993142 PAX8;LOC440839;LOC654433 -0.52 -6.93 -0.36 2.23e-11 Renal function-related traits (BUN); CRC cis rs6502050 0.731 rs9892653 chr17:80100191 G/T cg19223190 chr17:80058835 NA 0.4 6.36 0.33 6.88e-10 Life satisfaction; CRC cis rs12541635 0.677 rs1006480 chr8:106975524 T/C cg10147462 chr8:107024639 NA 0.55 9.3 0.46 2.01e-18 Age of smoking initiation; CRC cis rs7617480 0.648 rs9284885 chr3:48883100 A/C cg07636037 chr3:49044803 WDR6 0.86 11.72 0.54 9.64e-27 Subjective well-being (multi-trait analysis);Menarche (age at onset); CRC cis rs919433 1.000 rs2889363 chr2:198163699 A/G cg20885578 chr2:198174922 NA -0.36 -6.44 -0.33 4.3e-10 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC cis rs875971 0.522 rs10807697 chr7:65416170 A/G cg02869306 chr7:64672164 INTS4L1 -0.36 -5.92 -0.31 8.28e-9 Aortic root size; CRC cis rs11098499 0.604 rs12642411 chr4:120580525 T/C cg09307838 chr4:120376055 NA 0.67 9.94 0.48 1.6e-20 Corneal astigmatism; CRC cis rs7208859 0.623 rs9911784 chr17:29124580 A/C cg01831904 chr17:28903510 LRRC37B2 -0.62 -6.41 -0.33 5.13e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs4664293 0.669 rs357021 chr2:160489083 G/C cg08347373 chr2:160653686 CD302 -0.39 -6.74 -0.35 7.15e-11 Monocyte percentage of white cells; CRC trans rs3733585 0.699 rs7663097 chr4:9966791 T/C cg26043149 chr18:55253948 FECH -0.49 -7.42 -0.38 9.82e-13 Cleft plate (environmental tobacco smoke interaction); CRC trans rs7618501 1.000 rs2234391 chr3:49842625 A/G cg21659725 chr3:3221576 CRBN 0.85 16.04 0.66 3.66e-43 Intelligence (multi-trait analysis); CRC cis rs4713118 0.527 rs36042294 chr6:27720712 C/G cg06470822 chr6:28175283 NA 0.64 9.21 0.45 3.97e-18 Parkinson's disease; CRC cis rs7727544 0.716 rs10058655 chr5:131570896 A/T cg18301423 chr5:131593218 PDLIM4 0.3 5.64 0.3 3.66e-8 Blood metabolite levels; CRC cis rs6952808 0.929 rs12532128 chr7:1925454 T/C cg04267008 chr7:1944627 MAD1L1 -0.82 -12.6 -0.57 5.62e-30 Bipolar disorder and schizophrenia; CRC cis rs1127311 0.905 rs6702449 chr1:154583210 A/C cg24304309 chr1:154577895 ADAR 0.36 6.0 0.31 5.3e-9 C-reactive protein levels or triglyceride levels (pleiotropy); CRC cis rs875971 1.000 rs6958277 chr7:65979349 A/G cg18876405 chr7:65276391 NA 0.51 8.81 0.44 7.27e-17 Aortic root size; CRC cis rs710216 0.843 rs3768043 chr1:43419354 C/A cg03128534 chr1:43423976 SLC2A1 -0.46 -6.08 -0.32 3.29e-9 Red cell distribution width; CRC cis rs6815814 0.950 rs5743563 chr4:38806019 A/G cg06935464 chr4:38784597 TLR10 0.57 5.97 0.31 6.19e-9 Breast cancer; CRC cis rs1799949 1.000 rs8176145 chr17:41249094 A/G cg23758822 chr17:41437982 NA 0.8 13.43 0.59 4.46e-33 Menopause (age at onset); CRC cis rs6424115 1.000 rs7519554 chr1:24154566 T/A cg10978503 chr1:24200527 CNR2 -0.5 -8.86 -0.44 5.28e-17 Immature fraction of reticulocytes; CRC trans rs877282 0.755 rs11253399 chr10:790030 T/A cg22713356 chr15:30763199 NA 1.02 12.56 0.57 8.29e-30 Uric acid levels; CRC cis rs12701220 0.655 rs6463317 chr7:1159243 G/A cg06145435 chr7:1022769 CYP2W1 0.35 5.78 0.3 1.78e-8 Bronchopulmonary dysplasia; CRC cis rs9311474 0.508 rs7625743 chr3:52606366 C/G cg10802521 chr3:52805072 NEK4 -0.58 -9.23 -0.45 3.45e-18 Electroencephalogram traits; CRC cis rs427941 0.703 rs201449 chr7:101739054 A/G cg06246474 chr7:101738831 CUX1 0.44 6.88 0.35 3.02e-11 Plasma omega-3 polyunsaturated fatty acid level (eicosapentaenoic acid); CRC cis rs875971 0.862 rs3893216 chr7:65790707 G/C cg00343986 chr7:65444356 GUSB -0.45 -6.17 -0.32 1.99e-9 Aortic root size; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg08247611 chr16:71928811 KIAA0174 0.53 6.83 0.35 4.11e-11 Thyroid stimulating hormone; CRC trans rs7395662 0.963 rs2089209 chr11:48987120 C/T cg21153622 chr11:89784906 NA -0.49 -7.73 -0.39 1.31e-13 HDL cholesterol; CRC cis rs9549328 0.670 rs3011475 chr13:113616866 T/C cg20742385 chr13:113633654 MCF2L 0.55 9.32 0.46 1.7e-18 Systolic blood pressure; CRC cis rs7827545 1.000 rs9644456 chr8:135568656 G/T cg07299736 chr8:135490787 ZFAT -0.37 -6.31 -0.33 8.98e-10 Hypertension (SNP x SNP interaction); CRC cis rs853679 0.517 rs9380049 chr6:28048535 A/G cg18032046 chr6:28092343 ZSCAN16 -0.5 -5.89 -0.31 9.74e-9 Depression; CRC cis rs10752881 0.740 rs1889307 chr1:183049389 T/A ch.1.3577855R chr1:183094577 LAMC1 0.78 12.79 0.58 1.07e-30 Colorectal cancer; CRC cis rs2075371 0.966 rs2244690 chr7:133987039 A/G cg20476274 chr7:133979776 SLC35B4 0.8 14.55 0.63 2.29e-37 Mean platelet volume; CRC cis rs13144136 0.687 rs13143538 chr4:10656897 T/C cg10242279 chr4:10666415 CLNK -0.37 -6.38 -0.33 6.04e-10 Resistance to antihypertensive treatment in hypertension; CRC cis rs801193 0.660 rs974239 chr7:66213491 G/A cg00343986 chr7:65444356 GUSB 0.44 6.21 0.32 1.63e-9 Aortic root size; CRC cis rs2760061 0.583 rs1636195 chr1:228211589 T/C cg02753203 chr1:228287806 NA 0.98 14.73 0.63 4.43e-38 Diastolic blood pressure; CRC cis rs6499255 1.000 rs73579458 chr16:69804764 G/C cg15192750 chr16:69999425 NA 0.6 7.74 0.39 1.24e-13 IgE levels; CRC cis rs7937682 0.814 rs1784788 chr11:111486136 T/G cg19812747 chr11:111475976 SIK2 -0.59 -10.1 -0.49 4.38e-21 Primary sclerosing cholangitis; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg21611187 chr4:38321009 NA 0.39 6.11 0.32 2.89e-9 Intelligence (multi-trait analysis); CRC cis rs1799949 1.000 rs11655505 chr17:41278377 G/A cg23758822 chr17:41437982 NA 0.79 13.46 0.6 3.47e-33 Menopause (age at onset); CRC cis rs9443645 0.901 rs9443622 chr6:79582790 C/T cg05283184 chr6:79620031 NA -0.57 -9.21 -0.45 3.98e-18 Intelligence (multi-trait analysis); CRC cis rs7927592 0.913 rs12363722 chr11:68236291 A/C cg01657329 chr11:68192670 LRP5 -0.45 -6.32 -0.33 8.46e-10 Total body bone mineral density; CRC cis rs736408 0.562 rs2072390 chr3:52780509 A/T cg10802521 chr3:52805072 NEK4 -0.57 -8.79 -0.44 8.68e-17 Bipolar disorder; CRC cis rs72781680 0.716 rs2551334 chr2:24000396 G/A cg08917208 chr2:24149416 ATAD2B 0.56 6.58 0.34 1.87e-10 Lymphocyte counts; CRC cis rs12900413 0.687 rs12911196 chr15:90310734 G/C cg24249390 chr15:90295951 MESP1 -0.59 -9.32 -0.46 1.75e-18 Coronary artery aneurysm in Kawasaki disease; CRC cis rs1580019 0.961 rs4255041 chr7:32496383 A/G cg06627557 chr7:32535165 LSM5;AVL9 0.71 11.2 0.53 6.71e-25 Cognitive ability; CRC cis rs2425143 1.000 rs733609 chr20:34393074 A/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.49 -5.81 -0.3 1.51e-8 Blood protein levels; CRC cis rs1552244 0.554 rs34391585 chr3:9999208 G/C cg00166722 chr3:10149974 C3orf24 0.42 6.26 0.33 1.22e-9 Alzheimer's disease; CRC trans rs8073060 0.545 rs3859282 chr17:34006111 T/C cg19694781 chr19:47549865 TMEM160 -1.07 -14.34 -0.62 1.5e-36 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; CRC cis rs796364 0.951 rs59695400 chr2:201021325 C/T cg25936922 chr2:200820526 C2orf60;C2orf47 -0.64 -6.96 -0.36 1.87e-11 Schizophrenia; CRC cis rs1046896 0.731 rs9906115 chr17:80791469 G/A cg03160526 chr17:80928410 B3GNTL1 0.58 7.61 0.39 3.01e-13 Glycated hemoglobin levels; CRC trans rs7726839 0.540 rs28364691 chr5:664084 G/A cg11887960 chr12:57824829 NA 0.66 7.1 0.36 7.76e-12 Obesity-related traits; CRC cis rs698833 0.892 rs1067363 chr2:44658401 G/T cg04920474 chr2:44395004 PPM1B 0.39 5.75 0.3 2.05e-8 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; CRC cis rs6951245 0.678 rs28600085 chr7:1169636 C/T cg04025307 chr7:1156635 C7orf50 0.68 7.81 0.4 7.56e-14 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs12999616 0.817 rs35530168 chr2:98328477 C/G cg26665480 chr2:98280029 ACTR1B 0.52 6.43 0.33 4.6e-10 Colorectal cancer; CRC cis rs1577917 1.000 rs12215037 chr6:86727631 A/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.56 -6.99 -0.36 1.51e-11 Response to antipsychotic treatment; CRC cis rs66887589 0.934 rs6817317 chr4:120542827 A/G cg09307838 chr4:120376055 NA -0.51 -7.79 -0.39 8.79e-14 Diastolic blood pressure; CRC cis rs2576037 0.796 rs2571033 chr18:44578552 C/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 -0.46 -7.3 -0.37 2.14e-12 Personality dimensions; CRC trans rs61931739 0.500 rs73103774 chr12:34482279 C/T cg26384229 chr12:38710491 ALG10B 0.67 8.78 0.44 9.23e-17 Morning vs. evening chronotype; CRC cis rs2880765 0.566 rs12911430 chr15:86011264 A/T cg10818794 chr15:86012489 AKAP13 -0.49 -7.72 -0.39 1.44e-13 Coronary artery disease; CRC cis rs12760731 0.720 rs10913542 chr1:178348568 A/G cg00404053 chr1:178313656 RASAL2 0.71 9.0 0.44 1.79e-17 Obesity-related traits; CRC cis rs7223966 1.000 rs8066719 chr17:61825764 C/T cg05941027 chr17:61774174 LIMD2 0.37 6.56 0.34 2.11e-10 Hip circumference adjusted for BMI;Body mass index; CRC cis rs4601821 0.895 rs2282511 chr11:113244177 A/C cg14159747 chr11:113255604 NA 0.49 8.92 0.44 3.41e-17 Alcoholic chronic pancreatitis; CRC cis rs12431939 1.000 rs55851845 chr14:51645583 A/T cg23942311 chr14:51606299 NA -0.54 -6.1 -0.32 3.02e-9 Cancer; CRC cis rs9908102 0.740 rs7216235 chr17:12900383 C/T cg26162695 chr17:12921313 ELAC2 -0.43 -5.8 -0.3 1.55e-8 Schizophrenia; CRC cis rs1580019 0.520 rs6945238 chr7:32646096 C/T cg07520158 chr7:32535189 LSM5;AVL9 -0.45 -6.0 -0.31 5.12e-9 Cognitive ability; CRC cis rs7707921 0.767 rs226202 chr5:81571669 C/T cg07807695 chr5:81608485 ATP6AP1L -0.49 -7.79 -0.39 8.67e-14 Breast cancer; CRC cis rs2992756 0.663 rs3007733 chr1:18800911 C/T cg14356550 chr1:18808102 KLHDC7A -0.41 -5.83 -0.31 1.3e-8 Breast cancer; CRC cis rs7072216 0.763 rs2274244 chr10:100175218 A/G cg26618903 chr10:100175079 PYROXD2 -0.55 -8.99 -0.44 2.03e-17 Metabolite levels; CRC cis rs2073300 0.609 rs74809795 chr20:23372383 A/C cg12062639 chr20:23401060 NAPB 0.74 6.78 0.35 5.43e-11 Peripheral arterial disease (traffic-related air pollution interaction); CRC trans rs10982213 0.830 rs2274163 chr9:117188714 C/T cg10764405 chr11:67888285 CHKA 0.41 6.21 0.32 1.56e-9 Interleukin-6 levels; CRC cis rs12476592 0.602 rs262483 chr2:63877246 G/C cg10828910 chr2:63850056 LOC388955 0.49 6.15 0.32 2.31e-9 Childhood ear infection; CRC cis rs8180040 0.764 rs11716539 chr3:47186503 G/T cg02527881 chr3:46936655 PTH1R -0.37 -6.94 -0.36 2.05e-11 Colorectal cancer; CRC cis rs7129556 0.954 rs10899387 chr11:77276188 C/T cg12586386 chr11:77299805 AQP11 0.41 5.74 0.3 2.19e-8 Weight loss (gastric bypass surgery); CRC cis rs17666538 0.539 rs1703925 chr8:608279 A/G cg07685180 chr8:600429 NA 0.74 7.12 0.37 6.78e-12 IgG glycosylation; CRC trans rs1005277 0.540 rs4934907 chr10:38015230 A/C cg17830980 chr10:43048298 ZNF37B -0.4 -6.24 -0.33 1.38e-9 Extrinsic epigenetic age acceleration; CRC cis rs1451375 0.550 rs10239830 chr7:50603829 A/G cg14593290 chr7:50529359 DDC 0.63 8.33 0.42 2.24e-15 Malaria; CRC cis rs12477438 1.000 rs11897712 chr2:99735697 G/A cg26064155 chr2:99771622 LIPT1;TSGA10 -0.74 -9.08 -0.45 1.05e-17 Chronic sinus infection; CRC cis rs919433 0.963 rs1429417 chr2:198158171 T/G cg03934865 chr2:198174659 NA -0.45 -8.05 -0.41 1.54e-14 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC cis rs1707322 0.964 rs785483 chr1:46559171 T/C cg03146154 chr1:46216737 IPP -0.52 -7.18 -0.37 4.54e-12 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs4713118 0.869 rs6930992 chr6:27712120 A/C cg20933634 chr6:27740509 NA 0.58 8.5 0.42 6.74e-16 Parkinson's disease; CRC cis rs9527 0.637 rs12219247 chr10:104613361 A/G cg04362960 chr10:104952993 NT5C2 0.59 8.15 0.41 7.56e-15 Arsenic metabolism; CRC cis rs9322193 0.962 rs4816 chr6:150114745 G/A cg05861140 chr6:150128134 PCMT1 -0.43 -7.05 -0.36 1.03e-11 Lung cancer; CRC cis rs6860806 0.507 rs272872 chr5:131675864 C/T cg18301423 chr5:131593218 PDLIM4 -0.36 -6.18 -0.32 1.91e-9 Breast cancer; CRC cis rs2735413 0.875 rs8045975 chr16:78090187 C/G cg04733911 chr16:78082701 NA 0.43 7.1 0.36 7.71e-12 Systolic blood pressure (alcohol consumption interaction); CRC trans rs2303319 0.504 rs2175142 chr2:162450124 T/C cg14875682 chr5:52083620 ITGA1;PELO -0.72 -5.97 -0.31 6.06e-9 Cognitive function; CRC cis rs77106637 0.932 rs74439784 chr11:72649396 A/T cg03713592 chr11:72463424 ARAP1 0.73 7.37 0.38 1.39e-12 Type 2 diabetes; CRC cis rs7586673 0.866 rs747003 chr2:161916409 C/T cg22496339 chr2:162101262 NA -0.49 -6.77 -0.35 5.96e-11 Intelligence (multi-trait analysis); CRC cis rs7481584 0.624 rs412149 chr11:3069943 G/A cg25174290 chr11:3078921 CARS -0.43 -5.92 -0.31 8.14e-9 Calcium levels; CRC trans rs6561151 0.681 rs4942249 chr13:44426804 C/A cg12856521 chr11:46389249 DGKZ 0.73 10.56 0.5 1.21e-22 Crohn's disease; CRC cis rs9902453 0.817 rs3115089 chr17:28031881 C/T cg26525008 chr17:28256777 EFCAB5;SSH2 0.62 9.53 0.47 3.47e-19 Coffee consumption (cups per day); CRC cis rs1223397 0.651 rs3001966 chr6:13312684 C/T cg07912922 chr6:13274314 PHACTR1 0.38 6.0 0.31 5.21e-9 Blood pressure; CRC cis rs1904096 0.506 rs12511433 chr4:95162425 G/A cg11021082 chr4:95130006 SMARCAD1 -0.53 -8.17 -0.41 6.63e-15 Type 2 diabetes; CRC cis rs12692738 0.526 rs355870 chr2:165631433 C/T cg03182029 chr2:165697222 COBLL1 0.5 5.87 0.31 1.09e-8 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);Waist-to-hip ratio adjusted for BMI in non-smokers;Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction);Waist-to-hip ratio adjusted for body mass index; CRC cis rs4523957 0.890 rs2281727 chr17:2117945 A/G cg16513277 chr17:2031491 SMG6 -0.54 -8.86 -0.44 5.29e-17 Autism spectrum disorder or schizophrenia;Schizophrenia; CRC trans rs1814175 0.645 rs28549248 chr11:50042740 C/T cg15704280 chr7:45808275 SEPT13 -0.93 -17.08 -0.69 2.88e-47 Height; CRC cis rs9660992 0.512 rs12142402 chr1:205128215 A/T cg00857998 chr1:205179979 DSTYK 0.48 6.58 0.34 1.86e-10 Mean corpuscular volume;Mean platelet volume; CRC cis rs2732480 0.500 rs2732461 chr12:48692802 C/A cg04545296 chr12:48745243 ZNF641 0.33 5.68 0.3 2.94e-8 Hemoglobin concentration;Red blood cell count;Hematocrit; CRC cis rs7584330 0.826 rs7604315 chr2:238381729 C/G cg16989719 chr2:238392110 NA -0.46 -8.56 -0.43 4.27e-16 Prostate cancer; CRC cis rs6496667 0.865 rs62019275 chr15:90874834 C/T cg04176472 chr15:90893244 GABARAPL3 0.67 7.76 0.39 1.09e-13 Rheumatoid arthritis; CRC cis rs801193 0.569 rs10950050 chr7:66239588 A/C cg12463550 chr7:65579703 CRCP 0.44 6.11 0.32 2.85e-9 Aortic root size; CRC cis rs9903692 0.954 rs1010228 chr17:46200348 A/C cg21215337 chr17:46176117 CBX1 -0.43 -7.95 -0.4 3.09e-14 Pulse pressure; CRC cis rs10504229 0.636 rs77753517 chr8:58115897 C/T cg05313129 chr8:58192883 C8orf71 -0.43 -6.11 -0.32 2.74e-9 Developmental language disorder (linguistic errors); CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg22947959 chr10:75670903 PLAU;C10orf55 0.43 6.02 0.31 4.73e-9 Anxiety disorder; CRC cis rs1580019 0.922 rs59938271 chr7:32484844 T/C cg06627557 chr7:32535165 LSM5;AVL9 0.83 12.55 0.57 8.97e-30 Cognitive ability; CRC cis rs11212617 0.875 rs10789659 chr11:108255828 C/T cg12106634 chr11:108092400 ATM;NPAT 0.41 5.96 0.31 6.59e-9 Response to metformin in type 2 diabetes (glycemic); CRC cis rs1005277 0.579 rs2505241 chr10:38442421 T/C cg25427524 chr10:38739819 LOC399744 -0.76 -13.42 -0.59 4.71e-33 Extrinsic epigenetic age acceleration; CRC cis rs752010 0.619 rs7539238 chr1:42113572 A/C cg06885757 chr1:42089581 HIVEP3 0.39 6.25 0.33 1.24e-9 Lupus nephritis in systemic lupus erythematosus; CRC cis rs7552404 1.000 rs12123977 chr1:76209754 A/G cg03433033 chr1:76189801 ACADM -0.75 -10.09 -0.49 4.8e-21 Blood metabolite levels;Acylcarnitine levels; CRC cis rs7149337 0.805 rs71422017 chr14:51612417 A/T cg23942311 chr14:51606299 NA 0.83 17.41 0.69 1.4e-48 Cancer; CRC cis rs35306767 0.953 rs11253521 chr10:976416 G/C cg26597838 chr10:835615 NA 0.77 9.79 0.48 4.92e-20 Eosinophil percentage of granulocytes; CRC cis rs919433 0.963 rs6738836 chr2:198182432 A/G cg10820045 chr2:198174542 NA -0.53 -9.12 -0.45 7.78e-18 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC cis rs2019137 0.560 rs6707386 chr2:113981022 G/A cg21550016 chr2:113992930 PAX8;LOC440839;LOC654433 0.69 10.4 0.5 4.2e-22 Lymphocyte counts; CRC cis rs10751667 0.961 rs6597971 chr11:928598 T/A cg23136738 chr11:925521 AP2A2 -0.5 -7.92 -0.4 3.57e-14 Alzheimer's disease (late onset); CRC trans rs875971 0.660 rs2191268 chr7:66110224 C/T cg06559547 chr6:86387318 SNHG5;SNORD50B;SNORD50A -0.43 -6.89 -0.36 2.88e-11 Aortic root size; CRC cis rs2075371 0.933 rs1421481 chr7:133964380 A/C cg02659138 chr7:134003124 SLC35B4 0.35 6.12 0.32 2.7e-9 Mean platelet volume; CRC cis rs1018836 0.770 rs13266461 chr8:91652817 T/C cg16814680 chr8:91681699 NA -0.88 -15.14 -0.64 1.2e-39 Ejection fraction in Tripanosoma cruzi seropositivity; CRC cis rs6061231 1.000 rs11908473 chr20:60957770 C/G cg24112000 chr20:60950667 NA -0.62 -10.25 -0.49 1.38e-21 Colorectal cancer; CRC cis rs853679 0.517 rs1340004 chr6:28103691 C/T cg25164649 chr6:28176230 NA 0.78 9.81 0.48 4.4e-20 Depression; CRC cis rs2032447 0.802 rs199755 chr6:25990367 G/A cg12588279 chr6:26043732 HIST1H2BB 0.48 6.9 0.36 2.76e-11 Intelligence (multi-trait analysis); CRC cis rs919433 0.927 rs1429412 chr2:198190894 A/G cg10820045 chr2:198174542 NA -0.52 -8.79 -0.44 8.27e-17 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC cis rs4718428 0.705 rs2901311 chr7:66415069 T/C cg18252515 chr7:66147081 NA -0.52 -7.18 -0.37 4.73e-12 Corneal structure; CRC cis rs9311474 0.607 rs4475032 chr3:52560021 C/T cg07507251 chr3:52567010 NT5DC2 0.48 7.29 0.37 2.34e-12 Electroencephalogram traits; CRC cis rs172166 0.694 rs203893 chr6:28062066 C/A cg12172441 chr6:28176163 NA 0.54 7.35 0.38 1.62e-12 Cardiac Troponin-T levels; CRC cis rs7607369 0.637 rs17462630 chr2:219286541 C/G cg02176678 chr2:219576539 TTLL4 -0.6 -8.71 -0.43 1.52e-16 Red blood cell count;Amyotrophic lateral sclerosis; CRC cis rs4727027 0.933 rs12540094 chr7:148847178 A/G cg23583168 chr7:148888333 NA 0.87 14.74 0.63 4.22e-38 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC cis rs6963495 0.818 rs116457537 chr7:105152072 A/G cg02135003 chr7:105160482 PUS7 -0.9 -12.16 -0.56 2.37e-28 Bipolar disorder (body mass index interaction); CRC cis rs3751196 0.908 rs7295408 chr12:104212599 T/C cg02344784 chr12:104178138 NT5DC3 0.69 8.05 0.41 1.53e-14 Sense of smell; CRC trans rs11098499 0.818 rs55825515 chr4:120486402 A/G cg25214090 chr10:38739885 LOC399744 0.66 10.32 0.49 7.82e-22 Corneal astigmatism; CRC cis rs62064224 0.714 rs4794915 chr17:30634363 A/G cg18200150 chr17:30822561 MYO1D -0.47 -9.44 -0.46 7.04e-19 Schizophrenia; CRC cis rs989128 0.642 rs8077316 chr17:48626389 C/T cg24438145 chr17:48624694 SPATA20 0.52 7.41 0.38 1.04e-12 Type 2 diabetes; CRC cis rs1865760 0.566 rs9358904 chr6:26068566 C/T cg16482183 chr6:26056742 HIST1H1C 0.54 8.04 0.41 1.61e-14 Height; CRC cis rs4563143 0.675 rs73029049 chr19:29275534 C/A cg03161606 chr19:29218774 NA 0.53 6.68 0.35 1.04e-10 Methadone dose in opioid dependence; CRC cis rs9430161 0.579 rs11121667 chr1:11038476 C/T cg27631724 chr1:11040367 C1orf127 0.36 7.57 0.38 3.89e-13 Ewing sarcoma; CRC cis rs875971 0.965 rs9969301 chr7:65781655 G/A cg11764359 chr7:65958608 NA -0.62 -10.01 -0.48 9.08e-21 Aortic root size; CRC cis rs9359856 0.517 rs17506515 chr6:90507332 G/A cg13799429 chr6:90582589 CASP8AP2 -0.73 -8.2 -0.41 5.3e-15 Bipolar disorder; CRC cis rs637571 0.726 rs669371 chr11:65674153 G/T cg04055107 chr11:65626734 MUS81;CFL1 -0.43 -6.08 -0.32 3.25e-9 Eosinophil percentage of white cells; CRC cis rs7264396 0.887 rs2236165 chr20:34096725 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.37 -6.22 -0.32 1.47e-9 Total cholesterol levels; CRC cis rs9818758 0.607 rs9850917 chr3:49286983 A/G cg07636037 chr3:49044803 WDR6 -0.7 -6.14 -0.32 2.36e-9 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; CRC cis rs9372498 0.536 rs62424198 chr6:118827247 A/G cg22561889 chr6:118971681 C6orf204 0.51 6.55 0.34 2.19e-10 Diastolic blood pressure; CRC cis rs9640161 0.783 rs1132261 chr7:150059987 G/A cg13722127 chr7:150037890 RARRES2 0.39 5.73 0.3 2.21e-8 Blood protein levels;Circulating chemerin levels; CRC cis rs7647973 0.626 rs4855849 chr3:49653378 A/G cg03060546 chr3:49711283 APEH 0.68 8.22 0.41 4.71e-15 Menarche (age at onset); CRC cis rs6502050 0.835 rs4789737 chr17:80123269 G/A cg11859384 chr17:80120422 CCDC57 -0.36 -5.75 -0.3 2.06e-8 Life satisfaction; CRC cis rs832540 0.669 rs173764 chr5:56198920 C/T cg03609598 chr5:56110824 MAP3K1 -0.57 -7.83 -0.4 6.6e-14 Coronary artery disease; CRC cis rs9354308 0.933 rs2814131 chr6:66562051 T/A cg07460842 chr6:66804631 NA 0.47 5.9 0.31 9.09e-9 Metabolite levels; CRC cis rs9549328 0.670 rs3011475 chr13:113616866 T/C cg08614441 chr13:113633676 MCF2L 0.4 7.0 0.36 1.45e-11 Systolic blood pressure; CRC cis rs4713118 0.662 rs9380045 chr6:28025279 A/G cg15786705 chr6:28176104 NA 0.69 9.22 0.45 3.64e-18 Parkinson's disease; CRC cis rs2836950 0.501 rs62223052 chr21:40708702 A/C cg17971929 chr21:40555470 PSMG1 -0.5 -6.88 -0.35 3.01e-11 Menarche (age at onset); CRC cis rs7119 0.931 rs62009087 chr15:77833064 C/T cg27398640 chr15:77910606 LINGO1 -0.4 -7.01 -0.36 1.37e-11 Type 2 diabetes; CRC cis rs7552404 0.731 rs61770552 chr1:76373050 T/C cg03433033 chr1:76189801 ACADM 0.72 8.73 0.43 1.35e-16 Blood metabolite levels;Acylcarnitine levels; CRC cis rs9443645 0.611 rs10943616 chr6:79823541 G/A cg05283184 chr6:79620031 NA -0.4 -5.78 -0.3 1.76e-8 Intelligence (multi-trait analysis); CRC cis rs9916302 0.851 rs11078906 chr17:37662767 C/T cg07936489 chr17:37558343 FBXL20 -0.79 -11.94 -0.55 1.5e-27 Glomerular filtration rate (creatinine); CRC cis rs9910055 0.531 rs6503490 chr17:42246656 A/G cg09913183 chr17:42254507 C17orf65;ASB16 0.63 9.87 0.48 2.65e-20 Total body bone mineral density; CRC cis rs10760279 0.584 rs10760280 chr9:126112812 A/G cg14503395 chr9:126128745 CRB2 0.38 6.18 0.32 1.85e-9 Body mass index; CRC cis rs12477438 0.520 rs34766932 chr2:99737273 G/A cg26064155 chr2:99771622 LIPT1;TSGA10 0.83 14.79 0.63 2.57e-38 Chronic sinus infection; CRC cis rs2836950 0.545 rs8132143 chr21:40584258 A/T cg06238570 chr21:40685208 BRWD1 -0.62 -9.08 -0.45 1.05e-17 Menarche (age at onset); CRC cis rs9393692 0.905 rs9393694 chr6:26279296 T/C cg13736514 chr6:26305472 NA -0.61 -11.46 -0.53 8.56e-26 Educational attainment; CRC cis rs55986470 0.670 rs56313033 chr2:239346202 C/T cg18131467 chr2:239335373 ASB1 -0.71 -6.28 -0.33 1.06e-9 Chronotype; CRC cis rs356992 0.874 rs168565 chr2:60744331 A/G cg08426369 chr2:60753602 BCL11A 0.53 7.31 0.37 2.09e-12 Educational attainment (years of education); CRC cis rs116095464 0.558 rs55833259 chr5:286728 G/A cg22496380 chr5:211416 CCDC127 -0.98 -9.75 -0.47 6.54e-20 Breast cancer; CRC cis rs12477438 0.765 rs62154861 chr2:99590235 T/C cg14399236 chr2:99771627 LIPT1;TSGA10 -0.71 -9.93 -0.48 1.71e-20 Chronic sinus infection; CRC cis rs7147624 1.000 rs4902408 chr14:66111901 A/T cg03016385 chr14:66212404 NA -1.04 -10.96 -0.52 4.87e-24 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs12024301 0.557 rs12044922 chr1:183613088 A/C cg11505048 chr1:183622726 RGL1;APOBEC4 0.81 7.0 0.36 1.42e-11 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs9372498 0.505 rs62424202 chr6:118851027 T/C cg01339444 chr6:118972232 C6orf204 0.53 5.98 0.31 5.71e-9 Diastolic blood pressure; CRC cis rs9916302 0.904 rs634365 chr17:37436966 C/T cg07936489 chr17:37558343 FBXL20 -0.8 -12.59 -0.57 6.27e-30 Glomerular filtration rate (creatinine); CRC cis rs1524976 1.000 rs2037670 chr3:65488142 C/A cg16238336 chr3:65465873 MAGI1 -0.53 -6.81 -0.35 4.72e-11 PR interval; CRC cis rs9372498 0.536 rs72952733 chr6:118834452 A/G cg18833306 chr6:118973337 C6orf204 0.44 5.73 0.3 2.26e-8 Diastolic blood pressure; CRC cis rs9488822 0.676 rs7774952 chr6:116380909 A/G cg15226275 chr6:116381976 FRK 0.29 8.23 0.41 4.46e-15 Cholesterol, total;LDL cholesterol; CRC cis rs4660214 0.694 rs16866216 chr1:39674588 A/G cg11070191 chr1:39582205 MACF1 0.37 5.89 0.31 9.61e-9 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs992157 0.717 rs3817266 chr2:219142594 C/T cg04880052 chr2:219191631 PNKD -0.44 -6.98 -0.36 1.66e-11 Colorectal cancer; CRC cis rs12477438 0.765 rs6737257 chr2:99683330 G/A cg26064155 chr2:99771622 LIPT1;TSGA10 -0.63 -8.55 -0.43 4.61e-16 Chronic sinus infection; CRC trans rs61931739 0.500 rs7971957 chr12:34477558 C/T cg26384229 chr12:38710491 ALG10B 0.61 8.97 0.44 2.25e-17 Morning vs. evening chronotype; CRC cis rs7586879 0.639 rs2033653 chr2:25103446 C/T cg22495460 chr2:25135724 ADCY3 0.84 16.12 0.66 1.65e-43 Body mass index; CRC cis rs1129187 0.686 rs6458313 chr6:42922018 A/G cg09436375 chr6:42928200 GNMT -0.34 -6.25 -0.33 1.29e-9 Alzheimer's disease in APOE e4+ carriers; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg25593040 chr2:118572325 DDX18 0.47 6.21 0.32 1.56e-9 Thyroid stimulating hormone; CRC cis rs9896933 0.830 rs607544 chr17:80768760 C/G cg15664640 chr17:80829946 TBCD -0.59 -6.84 -0.35 3.76e-11 Bone mineral accretion in asthma (oral corticosteroid dose interaction); CRC cis rs59574136 1 rs59574136 chr7:2036460 T/C cg02951883 chr7:2050386 MAD1L1 -0.77 -12.7 -0.57 2.37e-30 Autism spectrum disorder or schizophrenia; CRC cis rs13191362 1.000 rs55822577 chr6:163069710 G/A cg06582575 chr6:163149167 PACRG;PARK2 0.93 11.9 0.55 2.04e-27 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs892961 0.932 rs35657663 chr17:75412482 T/C cg05865280 chr17:75406074 SEPT9 0.63 14.51 0.62 3.27e-37 Airflow obstruction; CRC cis rs55823223 0.564 rs936396 chr17:73846829 C/G cg10935138 chr17:73851978 WBP2 0.55 6.91 0.36 2.49e-11 Psoriasis; CRC cis rs7274811 0.681 rs291674 chr20:31954890 C/G cg03904042 chr20:32255491 NECAB3;C20orf134 0.44 6.19 0.32 1.77e-9 Height; CRC cis rs1862618 0.853 rs9283717 chr5:56078659 G/A cg18230493 chr5:56204884 C5orf35 -0.77 -9.72 -0.47 8.65e-20 Initial pursuit acceleration; CRC cis rs798554 0.683 rs1636264 chr7:2864586 G/T cg19717773 chr7:2847554 GNA12 -0.44 -6.65 -0.34 1.23e-10 Height; CRC cis rs13108904 0.535 rs1250101 chr4:1236111 G/A cg19318889 chr4:1322082 MAEA -0.63 -8.69 -0.43 1.79e-16 Obesity-related traits; CRC cis rs9303401 0.625 rs10515159 chr17:56802693 G/C cg02118635 chr17:56770003 RAD51C;TEX14 0.79 10.13 0.49 3.5e-21 Cognitive test performance; CRC cis rs72781680 1.000 rs72796337 chr2:24142957 G/A cg08917208 chr2:24149416 ATAD2B 0.91 9.24 0.45 3.06e-18 Lymphocyte counts; CRC cis rs796364 1.000 rs281785 chr2:200749566 A/G cg23649088 chr2:200775458 C2orf69 0.53 5.75 0.3 2.01e-8 Schizophrenia; CRC cis rs9443645 0.901 rs9448588 chr6:79590061 T/G cg09184832 chr6:79620586 NA -0.5 -9.44 -0.46 7.24e-19 Intelligence (multi-trait analysis); CRC cis rs6952808 0.723 rs60432611 chr7:2029629 G/C cg02951883 chr7:2050386 MAD1L1 -0.78 -12.8 -0.58 1.04e-30 Bipolar disorder and schizophrenia; CRC cis rs11628318 0.660 rs12887323 chr14:103083322 T/C cg08075719 chr14:103021372 NA -0.68 -7.94 -0.4 3.23e-14 Platelet count; CRC cis rs11764590 0.715 rs11760737 chr7:2104055 T/C cg23422044 chr7:1970798 MAD1L1 -0.5 -5.84 -0.31 1.24e-8 Neuroticism; CRC cis rs9649465 0.934 rs718781 chr7:123313573 T/C cg03229431 chr7:123269106 ASB15 -0.37 -5.71 -0.3 2.54e-8 Migraine; CRC cis rs11677416 1.000 rs3783514 chr2:113547425 A/G cg27083787 chr2:113543245 IL1A 0.44 6.07 0.32 3.43e-9 Response to antipsychotic treatment in schizophrenia (working memory); CRC cis rs780096 0.526 rs2911713 chr2:27640980 G/A cg24768116 chr2:27665128 KRTCAP3 -0.34 -7.76 -0.39 1.08e-13 Total body bone mineral density; CRC cis rs11625487 0.957 rs10145540 chr14:77957354 C/T cg20045696 chr14:77926864 AHSA1 -0.55 -7.11 -0.37 7.05e-12 Neutrophil percentage of white cells;Sum neutrophil eosinophil counts;Neutrophil count; CRC cis rs9393777 0.920 rs13195040 chr6:27413924 C/T cg15845792 chr6:28175446 NA -0.85 -5.72 -0.3 2.36e-8 Intelligence (multi-trait analysis); CRC cis rs60154123 0.505 rs76426571 chr1:210041634 C/T cg22029157 chr1:209979665 IRF6 0.61 6.76 0.35 6.47e-11 Coronary artery disease; CRC cis rs2204008 0.744 rs11182316 chr12:38499552 G/A cg13010199 chr12:38710504 ALG10B 0.46 5.88 0.31 9.81e-9 Bladder cancer; CRC cis rs1799949 1.000 rs12944458 chr17:41180772 C/T cg19454999 chr17:41278357 BRCA1;NBR2 0.53 7.99 0.4 2.31e-14 Menopause (age at onset); CRC cis rs12431939 0.598 rs12437085 chr14:51728941 G/T cg23942311 chr14:51606299 NA 0.51 6.77 0.35 6.02e-11 Cancer; CRC cis rs9393692 0.620 rs9393697 chr6:26293841 C/T cg13736514 chr6:26305472 NA -0.46 -7.6 -0.39 3.21e-13 Educational attainment; CRC cis rs10426930 0.607 rs2613768 chr19:5074637 G/A cg18473234 chr19:5097819 KDM4B -0.54 -6.77 -0.35 6.02e-11 Monocyte percentage of white cells; CRC trans rs10506458 1.000 rs10506458 chr12:63445092 G/A cg22491629 chr6:157744540 C6orf35 -0.72 -8.72 -0.43 1.4e-16 Hemostatic factors and hematological phenotypes; CRC cis rs62064224 0.589 rs9889607 chr17:30785585 A/C cg12855166 chr17:30846586 MYO1D 0.34 5.65 0.3 3.41e-8 Schizophrenia; CRC cis rs11229555 0.609 rs11229451 chr11:58201687 T/C cg15696309 chr11:58395628 NA -0.82 -10.31 -0.49 8.59e-22 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; CRC cis rs6952808 0.771 rs10244946 chr7:1921068 A/G cg14004847 chr7:1930337 MAD1L1 0.46 6.67 0.35 1.05e-10 Bipolar disorder and schizophrenia; CRC cis rs947211 0.846 rs823155 chr1:205762946 T/C cg07157834 chr1:205819609 PM20D1 0.45 6.5 0.34 2.96e-10 Parkinson's disease; CRC cis rs4332037 0.539 rs56305291 chr7:2048706 A/G cg21155852 chr7:2048760 MAD1L1 -0.53 -7.08 -0.36 8.98e-12 Bipolar disorder; CRC cis rs9359856 0.510 rs6937789 chr6:90468775 C/G cg13799429 chr6:90582589 CASP8AP2 0.76 9.94 0.48 1.56e-20 Bipolar disorder; CRC cis rs9549367 0.789 rs12584981 chr13:113881185 T/C cg00898013 chr13:113819073 PROZ -0.46 -6.75 -0.35 6.67e-11 Platelet distribution width; CRC trans rs7267979 0.932 rs431579 chr20:25470056 T/C cg17903999 chr18:56338584 MALT1 -0.4 -6.82 -0.35 4.4e-11 Liver enzyme levels (alkaline phosphatase); CRC cis rs916888 0.773 rs9896243 chr17:44826056 C/G cg01570182 chr17:44337453 NA 1.18 13.33 0.59 1.03e-32 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs6141769 0.518 rs2377665 chr20:31309054 T/C cg13636640 chr20:31349939 DNMT3B -0.38 -5.84 -0.31 1.22e-8 Subjective well-being; CRC cis rs28655083 0.828 rs7190227 chr16:77119568 T/C cg01753188 chr16:77233325 SYCE1L;MON1B 0.58 8.31 0.42 2.63e-15 Lobe attachment (rater-scored or self-reported); CRC cis rs17162190 0.698 rs4970514 chr1:26846195 C/T cg17456097 chr1:26900765 RPS6KA1 0.42 6.13 0.32 2.54e-9 Mean corpuscular volume; CRC cis rs10504073 0.647 rs10105794 chr8:50012793 G/C cg00325661 chr8:49890786 NA 0.42 7.51 0.38 5.6e-13 Blood metabolite ratios; CRC cis rs634534 0.561 rs14157 chr11:65769780 T/G cg26695010 chr11:65641043 EFEMP2 -0.39 -5.97 -0.31 6.06e-9 Sum eosinophil basophil counts;Eosinophil counts; CRC cis rs10504229 0.728 rs17216187 chr8:58158778 G/T cg11062466 chr8:58055876 NA 0.45 6.01 0.31 4.87e-9 Developmental language disorder (linguistic errors); CRC cis rs11971779 0.616 rs6965143 chr7:139026608 C/G cg23387468 chr7:139079360 LUC7L2 0.4 7.13 0.37 6.58e-12 Diisocyanate-induced asthma; CRC cis rs2239547 0.603 rs71301807 chr3:53085475 C/G cg11645453 chr3:52864694 ITIH4 0.49 8.0 0.4 2.12e-14 Schizophrenia; CRC cis rs9341808 0.622 rs684283 chr6:80967317 T/G cg08355045 chr6:80787529 NA -0.36 -5.93 -0.31 7.8e-9 Sitting height ratio; CRC trans rs66573146 1.000 rs56178503 chr4:6961748 C/T cg07817883 chr1:32538562 TMEM39B 1.45 13.05 0.58 1.22e-31 Granulocyte percentage of myeloid white cells; CRC cis rs490234 0.651 rs13291556 chr9:128240922 T/C cg14078157 chr9:128172775 NA -0.37 -5.99 -0.31 5.43e-9 Mean arterial pressure; CRC cis rs9372498 0.536 rs62663261 chr6:118900553 T/C cg15382696 chr6:118971807 C6orf204 0.58 7.38 0.38 1.29e-12 Diastolic blood pressure; CRC cis rs3820068 0.603 rs7531396 chr1:15969870 G/C cg13390004 chr1:15929781 NA 0.53 7.41 0.38 1.07e-12 Systolic blood pressure; CRC cis rs6061231 0.793 rs6061512 chr20:60976929 G/A cg24112000 chr20:60950667 NA -0.6 -9.29 -0.46 2.12e-18 Colorectal cancer; CRC cis rs7591163 0.883 rs11891398 chr2:228723357 C/T cg14646075 chr2:228736089 WDR69 -0.42 -5.8 -0.3 1.52e-8 Blood pressure; CRC cis rs7617773 0.780 rs6782166 chr3:48351683 A/G cg11946769 chr3:48343235 NME6 0.73 9.79 0.47 4.96e-20 Coronary artery disease; CRC cis rs2235649 0.663 rs6600167 chr16:1848912 A/G cg00935504 chr16:1863053 HAGH 0.31 5.62 0.3 4.07e-8 Blood metabolite levels; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg08366132 chr1:27191899 NA 0.46 6.46 0.34 3.88e-10 Response to antipsychotic treatment; CRC cis rs875971 0.928 rs6970357 chr7:65968878 T/C cg11764359 chr7:65958608 NA 0.63 10.25 0.49 1.39e-21 Aortic root size; CRC trans rs12517041 1.000 rs10057246 chr5:23294721 T/C ch.8.1293020R chr8:59333349 UBXN2B -0.55 -6.17 -0.32 2.05e-9 Calcium levels; CRC cis rs7618915 0.501 rs13060048 chr3:52598608 G/A cg08222913 chr3:52553049 STAB1 -0.34 -6.45 -0.34 4e-10 Bipolar disorder; CRC cis rs1223397 0.651 rs2458312 chr6:13309989 G/A cg07912922 chr6:13274314 PHACTR1 0.39 6.08 0.32 3.39e-9 Blood pressure; CRC cis rs10504229 0.683 rs59679713 chr8:58134370 G/C cg21724239 chr8:58056113 NA 0.49 6.86 0.35 3.39e-11 Developmental language disorder (linguistic errors); CRC cis rs7527798 0.544 rs11118354 chr1:207856868 A/G cg09232269 chr1:207846808 CR1L -0.45 -7.33 -0.37 1.84e-12 Erythrocyte sedimentation rate; CRC cis rs13108904 0.870 rs13132584 chr4:1251504 G/T cg21620606 chr4:1342894 KIAA1530 0.4 6.94 0.36 2.06e-11 Obesity-related traits; CRC cis rs6951245 1.000 rs78185801 chr7:1096367 G/A cg18402987 chr7:1209562 NA 0.67 7.15 0.37 5.54e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs4713118 0.662 rs9468277 chr6:28028390 C/A cg15786705 chr6:28176104 NA 0.69 9.22 0.45 3.53e-18 Parkinson's disease; CRC cis rs939658 1.000 rs17175798 chr15:79463960 A/G cg17916960 chr15:79447300 NA 0.44 7.24 0.37 3.14e-12 Refractive error; CRC trans rs7579899 0.927 rs2121266 chr2:46535924 A/C cg02204578 chr7:132766399 CHCHD3 0.42 5.99 0.31 5.37e-9 Renal cell carcinoma; CRC cis rs17767392 0.958 rs1981588 chr14:72039689 G/A cg13720639 chr14:72061746 SIPA1L1 0.56 6.88 0.35 2.96e-11 Mitral valve prolapse; CRC cis rs875971 0.965 rs697968 chr7:65535033 G/A cg18876405 chr7:65276391 NA -0.52 -8.8 -0.44 7.65e-17 Aortic root size; CRC cis rs13256369 0.901 rs12681327 chr8:8566414 G/T cg17143192 chr8:8559678 CLDN23 0.49 6.19 0.32 1.77e-9 Obesity-related traits; CRC cis rs2991971 0.933 rs12568144 chr1:45965307 G/A cg15605315 chr1:45957053 TESK2 0.41 6.6 0.34 1.65e-10 High light scatter reticulocyte count; CRC cis rs910316 0.737 rs108621 chr14:75480637 T/C cg11812906 chr14:75593930 NEK9 -0.55 -8.43 -0.42 1.11e-15 Height; CRC cis rs877282 1.000 rs877281 chr10:771557 T/G cg06581033 chr10:766294 NA -0.5 -5.76 -0.3 1.93e-8 Uric acid levels; CRC cis rs6502050 0.777 rs11077969 chr17:80085633 A/G cg22110888 chr17:80059540 CCDC57 -0.41 -6.39 -0.33 5.58e-10 Life satisfaction; CRC cis rs1348850 0.526 rs10803912 chr2:178407176 A/C cg27490568 chr2:178487706 NA -0.63 -7.66 -0.39 2.11e-13 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs8180040 1.000 rs4858888 chr3:47405305 C/T cg27129171 chr3:47204927 SETD2 -0.67 -10.62 -0.51 7.37e-23 Colorectal cancer; CRC cis rs3617 0.503 rs9866243 chr3:52915219 C/T cg15147215 chr3:52552868 STAB1 0.48 8.21 0.41 5.2e-15 Red blood cell count;Autism spectrum disorder or schizophrenia; CRC cis rs10504229 0.639 rs67996345 chr8:58117127 A/G cg02290350 chr8:58132656 NA -0.58 -8.16 -0.41 7.29e-15 Developmental language disorder (linguistic errors); CRC cis rs769267 0.895 rs2315279 chr19:19479936 C/A cg03709012 chr19:19516395 GATAD2A -0.72 -11.27 -0.53 3.81e-25 Tonsillectomy; CRC cis rs2050392 0.517 rs2489847 chr10:30743673 G/A cg25182066 chr10:30743637 MAP3K8 -0.62 -8.81 -0.44 7.22e-17 Inflammatory bowel disease; CRC cis rs9435341 0.896 rs1730850 chr1:107597988 C/T cg14671364 chr1:107599128 PRMT6 -0.62 -8.45 -0.42 9.23e-16 Facial morphology (factor 21, depth of nasal alae); CRC trans rs916888 0.821 rs199525 chr17:44847834 T/G cg10053473 chr17:62856997 LRRC37A3 -0.82 -8.74 -0.43 1.18e-16 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs7191439 0.583 rs9935872 chr16:88788477 A/G cg27087555 chr16:88793112 FAM38A -1.4 -14.49 -0.62 3.87e-37 Plateletcrit; CRC trans rs10504229 1.000 rs17217033 chr8:58180061 G/T cg04077850 chr5:125800366 GRAMD3 0.37 6.27 0.33 1.15e-9 Developmental language disorder (linguistic errors); CRC cis rs1552244 0.938 rs7652951 chr3:10063763 A/C cg13047869 chr3:10149882 C3orf24 0.51 7.07 0.36 9.31e-12 Alzheimer's disease; CRC cis rs4862750 0.872 rs6821507 chr4:187876829 G/T cg10295955 chr4:187884368 NA 1.01 24.82 0.81 2.18e-77 Lobe attachment (rater-scored or self-reported); CRC cis rs7959452 0.557 rs7980883 chr12:69778914 C/T cg22834771 chr12:69754056 YEATS4 -0.54 -8.1 -0.41 1.07e-14 Blood protein levels; CRC cis rs7119 0.717 rs12915548 chr15:77818042 A/G cg27398640 chr15:77910606 LINGO1 -0.43 -7.47 -0.38 7.13e-13 Type 2 diabetes; CRC cis rs654950 0.806 rs1535505 chr1:42026152 A/G cg06885757 chr1:42089581 HIVEP3 0.44 6.9 0.36 2.64e-11 Airway imaging phenotypes; CRC trans rs1814175 0.616 rs847641 chr11:49919261 T/C cg15704280 chr7:45808275 SEPT13 -0.95 -16.83 -0.68 2.82e-46 Height; CRC cis rs6120849 0.663 rs6119548 chr20:33552612 A/G cg24642439 chr20:33292090 TP53INP2 0.47 6.22 0.32 1.48e-9 Protein C levels; CRC cis rs995000 0.839 rs1168026 chr1:62970996 T/C cg19896129 chr1:63156450 NA -0.39 -6.08 -0.32 3.29e-9 Triglyceride levels; CRC cis rs9584850 0.708 rs4411372 chr13:99130423 T/C cg07423050 chr13:99094983 FARP1 0.45 6.17 0.32 2.04e-9 Neuroticism; CRC cis rs6460942 0.915 rs62448593 chr7:12436845 G/C cg06484146 chr7:12443880 VWDE -0.81 -8.52 -0.43 5.76e-16 Coronary artery disease; CRC cis rs4319547 0.695 rs11836188 chr12:122865507 T/C cg05707623 chr12:122985044 ZCCHC8 0.76 9.18 0.45 5.09e-18 Body mass index; CRC cis rs2836950 0.501 rs2836980 chr21:40687618 G/T cg17971929 chr21:40555470 PSMG1 -0.52 -7.38 -0.38 1.34e-12 Menarche (age at onset); CRC cis rs798554 0.797 rs798491 chr7:2800521 A/G cg17321639 chr7:2759063 NA -0.5 -6.42 -0.33 4.71e-10 Height; CRC cis rs6495367 1.000 rs1007365 chr15:79379492 T/G cg17916960 chr15:79447300 NA 0.37 6.17 0.32 1.95e-9 Spherical equivalent (joint analysis main effects and education interaction); CRC trans rs1455244 0.700 rs7229302 chr18:11508904 G/T cg01893439 chr7:148581376 EZH2 0.42 6.38 0.33 6.16e-10 Schizophrenia; CRC cis rs968567 0.559 rs174544 chr11:61567753 C/A cg06781209 chr11:61594997 FADS2 -0.42 -5.99 -0.31 5.58e-9 Blood metabolite levels;Rheumatoid arthritis;Vitiligo;Glycerophospholipid levels; CRC cis rs2836974 0.932 rs2836955 chr21:40619887 G/A cg11890956 chr21:40555474 PSMG1 1.03 16.5 0.67 5.26e-45 Cognitive function; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg15342139 chr6:170124938 PHF10 0.42 7.13 0.37 6.47e-12 Liver disease severity in Alagille syndrome; CRC cis rs4665809 0.590 rs5001914 chr2:26415429 A/G cg25036284 chr2:26402008 FAM59B -0.61 -7.7 -0.39 1.63e-13 Gut microbiome composition (summer); CRC cis rs9311474 0.629 rs4282054 chr3:52566065 T/C cg18591801 chr3:52553433 STAB1 -0.32 -6.17 -0.32 1.98e-9 Electroencephalogram traits; CRC cis rs28493229 0.708 rs10408065 chr19:41161096 T/C cg21869046 chr19:41225005 ITPKC 0.41 6.15 0.32 2.26e-9 Kawasaki disease; CRC cis rs6502050 0.830 rs7219036 chr17:80161119 T/C cg19223190 chr17:80058835 NA 0.41 6.62 0.34 1.49e-10 Life satisfaction; CRC cis rs9894429 1.000 rs7209180 chr17:79581519 C/A cg21028142 chr17:79581711 NPLOC4 0.39 8.62 0.43 2.89e-16 Eye color traits; CRC trans rs7873102 0.702 rs7028020 chr9:38007747 C/T cg07564175 chr17:8024546 HES7 -0.41 -5.99 -0.31 5.47e-9 Brain structure; CRC cis rs7635838 0.785 rs2594972 chr3:11397417 A/G cg00170343 chr3:11313890 ATG7 0.45 6.71 0.35 8.43e-11 HDL cholesterol; CRC cis rs2228479 0.702 rs17177891 chr16:89799950 C/T cg06656553 chr16:89960601 TCF25 -0.68 -5.66 -0.3 3.31e-8 Skin colour saturation; CRC cis rs1008375 1.000 rs4698635 chr4:17630242 C/A cg02297831 chr4:17616191 MED28 0.44 5.91 0.31 8.59e-9 Parasitemia in Tripanosoma cruzi seropositivity; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg02073511 chr16:3550924 CLUAP1 0.42 7.02 0.36 1.24e-11 Liver disease severity in Alagille syndrome; CRC cis rs2979489 0.699 rs17554116 chr8:30419334 C/T cg26383811 chr8:30366931 RBPMS -0.69 -9.84 -0.48 3.3e-20 Mean corpuscular hemoglobin;Plateletcrit;Neutrophil count;Granulocyte count;Sum basophil neutrophil counts;Mean corpuscular volume;Myeloid white cell count;Sum neutrophil eosinophil counts; CRC cis rs2050392 0.767 rs10763786 chr10:30693567 G/C cg25182066 chr10:30743637 MAP3K8 0.45 6.01 0.31 4.96e-9 Inflammatory bowel disease; CRC cis rs6951245 0.554 rs78999139 chr7:1138525 G/A cg26224354 chr7:1096374 C7orf50;GPR146 -0.6 -8.17 -0.41 6.67e-15 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC trans rs1005277 0.579 rs2023351 chr10:38378814 A/G cg27523141 chr10:43048294 ZNF37B 0.5 7.34 0.38 1.73e-12 Extrinsic epigenetic age acceleration; CRC cis rs7216064 0.684 rs7406031 chr17:66021753 C/T cg12091567 chr17:66097778 LOC651250 0.9 13.39 0.59 6.2e-33 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CRC cis rs7927771 0.864 rs55927797 chr11:47446292 A/T cg05585544 chr11:47624801 NA -0.52 -9.41 -0.46 8.6e-19 Subjective well-being; CRC cis rs9303280 0.836 rs11557467 chr17:38028634 G/T cg11212589 chr17:38028394 ZPBP2 0.48 9.02 0.45 1.62e-17 Self-reported allergy; CRC cis rs12048904 0.541 rs1571046 chr1:101299216 T/C cg16556008 chr1:101360663 SLC30A7;EXTL2 0.84 12.99 0.58 1.92e-31 Multiple sclerosis; CRC cis rs4713675 0.565 rs9348924 chr6:33705436 A/G cg14003231 chr6:33640908 ITPR3 0.43 7.08 0.36 8.96e-12 Plateletcrit; CRC cis rs13108904 0.875 rs10024013 chr4:1280792 C/T cg23123621 chr4:1343375 KIAA1530 -0.34 -6.2 -0.32 1.68e-9 Obesity-related traits; CRC cis rs9796 0.870 rs2925346 chr15:41315695 G/A cg18705301 chr15:41695430 NDUFAF1 0.34 5.67 0.3 3.19e-8 Menopause (age at onset); CRC cis rs4803480 0.507 rs10420992 chr19:42064462 T/A cg08478046 chr19:42093086 CEACAM21 -0.29 -6.17 -0.32 2.06e-9 Schizophrenia; CRC cis rs6963495 0.818 rs73190200 chr7:105165856 T/C cg13798780 chr7:105162888 PUS7 0.69 8.2 0.41 5.36e-15 Bipolar disorder (body mass index interaction); CRC cis rs951366 0.789 rs823130 chr1:205714372 C/T cg07157834 chr1:205819609 PM20D1 0.77 11.6 0.54 2.55e-26 Menarche (age at onset); CRC cis rs11098499 0.863 rs1480939 chr4:120456927 T/C cg24375607 chr4:120327624 NA 0.48 7.25 0.37 3.03e-12 Corneal astigmatism; CRC cis rs9811920 0.570 rs1021102 chr3:99603780 T/A cg07805332 chr3:99536008 MIR548G;C3orf26 -0.51 -7.68 -0.39 1.84e-13 Axial length; CRC cis rs3126085 0.673 rs3126089 chr1:152306187 T/A cg09127314 chr1:152161683 NA -0.45 -5.61 -0.3 4.29e-8 Atopic dermatitis; CRC cis rs6951245 0.832 rs79808627 chr7:1092519 C/G cg20603222 chr7:1096387 C7orf50;GPR146 -0.64 -8.57 -0.43 4.19e-16 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs6582630 0.638 rs10880620 chr12:38517467 A/G cg26384229 chr12:38710491 ALG10B -0.54 -7.75 -0.39 1.19e-13 Drug-induced liver injury (flucloxacillin); CRC cis rs11628318 0.853 rs28444760 chr14:103041148 A/G cg23071808 chr14:103021642 NA -0.7 -9.22 -0.45 3.53e-18 Platelet count; CRC cis rs853679 0.517 rs16893666 chr6:28054707 C/T cg15786705 chr6:28176104 NA -0.75 -9.6 -0.47 2.16e-19 Depression; CRC cis rs1032355 0.722 rs13139650 chr4:100513580 G/C cg05468953 chr4:100565104 NA 0.41 5.72 0.3 2.44e-8 Celiac disease; CRC cis rs6951245 1.000 rs11767527 chr7:1097394 T/C cg04025307 chr7:1156635 C7orf50 0.64 6.81 0.35 4.53e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs4561483 0.583 rs9925010 chr16:11956668 A/G cg08843971 chr16:11963173 GSPT1 0.52 7.76 0.39 1.1e-13 Testicular germ cell tumor; CRC cis rs17711722 0.727 rs35850374 chr7:65357776 A/G cg18876405 chr7:65276391 NA 0.65 11.91 0.55 1.97e-27 Calcium levels; CRC cis rs951366 0.789 rs823094 chr1:205689807 G/T cg23034840 chr1:205782522 SLC41A1 -0.46 -6.59 -0.34 1.8e-10 Menarche (age at onset); CRC cis rs6840360 0.593 rs10013612 chr4:152693622 A/G cg09659197 chr4:152720779 NA 0.41 8.5 0.42 6.5e-16 Intelligence (multi-trait analysis); CRC cis rs8141797 0.818 rs1985047 chr22:24580381 G/C cg20894457 chr22:24584366 SUSD2 0.65 7.8 0.4 8.27e-14 Amyotrophic lateral sclerosis;Coronary artery disease; CRC cis rs1867631 0.585 rs11208922 chr1:67080226 T/C cg02459107 chr1:67143332 SGIP1 0.34 6.18 0.32 1.95e-9 Menopause (age at onset); CRC cis rs6484504 0.576 rs11031323 chr11:31245413 T/G cg14844989 chr11:31128820 NA -0.34 -5.97 -0.31 5.99e-9 Red blood cell count; CRC cis rs2242116 0.932 rs7646906 chr3:46949379 G/A cg27129171 chr3:47204927 SETD2 0.51 7.38 0.38 1.34e-12 Birth weight; CRC cis rs4594175 0.926 rs12101170 chr14:51611902 T/C cg23942311 chr14:51606299 NA 0.65 10.48 0.5 2.33e-22 Cancer; CRC cis rs9611565 0.649 rs6002480 chr22:42176917 A/T cg03806693 chr22:41940476 POLR3H -0.67 -9.28 -0.46 2.26e-18 Vitiligo; CRC cis rs854765 0.505 rs4924832 chr17:17897739 A/G cg07919128 chr17:18022025 MYO15A -0.41 -6.81 -0.35 4.6e-11 Total body bone mineral density; CRC cis rs2839186 0.656 rs8128380 chr21:47665693 C/T cg00815214 chr21:47717953 NA -0.35 -6.04 -0.32 4.19e-9 Testicular germ cell tumor; CRC cis rs807029 0.544 rs55646950 chr10:102760996 C/T cg04662943 chr10:102668895 NA 0.61 7.13 0.37 6.44e-12 Ejection fraction in Tripanosoma cruzi seropositivity; CRC cis rs3741404 0.620 rs882147 chr11:63976689 T/A cg06243084 chr11:63990629 FERMT3 -0.39 -5.95 -0.31 6.76e-9 Platelet count; CRC cis rs72781680 0.799 rs2712084 chr2:24003051 A/G cg08917208 chr2:24149416 ATAD2B 0.56 6.56 0.34 2.06e-10 Lymphocyte counts; CRC cis rs6963495 0.745 rs73190179 chr7:105162812 C/A cg13798780 chr7:105162888 PUS7 0.68 8.08 0.41 1.27e-14 Bipolar disorder (body mass index interaction); CRC cis rs4332037 0.707 rs56070303 chr7:1891015 C/T cg23422044 chr7:1970798 MAD1L1 -0.49 -6.36 -0.33 6.81e-10 Bipolar disorder; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg02551244 chr2:23608357 KLHL29 0.44 6.2 0.32 1.72e-9 Response to antipsychotic treatment; CRC cis rs7927771 0.864 rs4752838 chr11:47466006 G/A cg05585544 chr11:47624801 NA -0.54 -9.69 -0.47 1.08e-19 Subjective well-being; CRC trans rs1814175 0.708 rs10839464 chr11:49981386 T/C cg11707556 chr5:10655725 ANKRD33B -0.52 -10.05 -0.48 6.61e-21 Height; CRC cis rs2576037 0.796 rs2571033 chr18:44578552 C/T cg19077165 chr18:44547161 KATNAL2 0.43 6.71 0.35 8.7e-11 Personality dimensions; CRC cis rs28386778 0.863 rs11649912 chr17:61797515 T/A cg07362569 chr17:61921086 SMARCD2 0.36 5.61 0.3 4.36e-8 Prudent dietary pattern; CRC cis rs853679 0.598 rs9380054 chr6:28067537 G/A cg18032046 chr6:28092343 ZSCAN16 -0.5 -5.89 -0.31 9.34e-9 Depression; CRC cis rs7591163 1.000 rs7591163 chr2:228715375 C/T cg00063174 chr2:228736253 WDR69 -0.51 -6.9 -0.36 2.6e-11 Blood pressure; CRC cis rs3791556 1.000 rs2411429 chr2:240113928 A/G cg03281426 chr2:240109471 HDAC4 0.63 6.86 0.35 3.4e-11 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs10911232 0.507 rs6668980 chr1:183018857 T/C ch.1.3577855R chr1:183094577 LAMC1 0.83 14.62 0.63 1.22e-37 Hypertriglyceridemia; CRC cis rs7208859 0.623 rs56378576 chr17:29010120 C/T cg01831904 chr17:28903510 LRRC37B2 -0.64 -6.28 -0.33 1.06e-9 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs904251 0.772 rs1224127 chr6:37417556 G/A cg01843034 chr6:37503916 NA -0.35 -5.67 -0.3 3.2e-8 Cognitive performance; CRC cis rs7727544 0.642 rs7705189 chr5:131623358 C/T cg14196790 chr5:131705035 SLC22A5 -0.34 -5.8 -0.3 1.52e-8 Blood metabolite levels; CRC cis rs3106136 0.967 rs17310266 chr4:95177051 T/C cg11021082 chr4:95130006 SMARCAD1 -0.46 -7.14 -0.37 5.97e-12 Capecitabine sensitivity; CRC cis rs3096299 0.719 rs2911265 chr16:89511328 G/A cg00750074 chr16:89608354 SPG7 -0.49 -7.44 -0.38 9.09e-13 Multiple myeloma (IgH translocation); CRC cis rs6120849 0.754 rs6088691 chr20:33633758 C/T cg08999081 chr20:33150536 PIGU 0.44 5.73 0.3 2.23e-8 Protein C levels; CRC cis rs12477438 0.520 rs13023744 chr2:99738224 C/T cg14399236 chr2:99771627 LIPT1;TSGA10 0.83 14.67 0.63 7.94e-38 Chronic sinus infection; CRC cis rs747650 0.798 rs11039086 chr11:47116033 G/C cg19486271 chr11:47235900 DDB2 -0.47 -7.12 -0.37 6.91e-12 Acne (severe); CRC cis rs9976767 1.000 rs34544259 chr21:43834854 A/G cg23042151 chr21:43824109 UBASH3A -0.33 -5.66 -0.3 3.3e-8 Type 1 diabetes; CRC cis rs6952808 0.689 rs12668156 chr7:2019875 G/A cg21782813 chr7:2030301 MAD1L1 0.54 9.24 0.45 3.14e-18 Bipolar disorder and schizophrenia; CRC cis rs9522267 0.535 rs6492373 chr13:112238627 T/C cg10483660 chr13:112241077 NA 0.5 9.77 0.47 5.89e-20 Hepatitis; CRC cis rs4563143 0.675 rs73029049 chr19:29275534 C/A cg12667521 chr19:29218732 NA 0.5 7.54 0.38 4.49e-13 Methadone dose in opioid dependence; CRC cis rs73206853 0.841 rs55951950 chr12:110800254 A/T cg12870014 chr12:110450643 ANKRD13A 0.8 7.68 0.39 1.89e-13 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC cis rs10256972 0.552 rs2960837 chr7:1203957 A/G cg07308232 chr7:1071921 C7orf50 -0.42 -5.64 -0.3 3.69e-8 Longevity;Endometriosis; CRC cis rs3750082 0.815 rs6964458 chr7:32935224 G/T cg05721444 chr7:32995514 FKBP9 0.49 7.45 0.38 8.12e-13 Glomerular filtration rate (creatinine); CRC cis rs7113874 0.569 rs10769924 chr11:8623193 C/A cg17679104 chr11:8615758 STK33 0.38 6.4 0.33 5.35e-10 Body mass index in physically active individuals;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs1178968 1.000 rs1178968 chr7:72767451 T/C cg25889504 chr7:72793014 NA 0.55 6.21 0.32 1.64e-9 Triglyceride levels; CRC cis rs9322193 0.884 rs933055 chr6:150130837 A/G cg07701084 chr6:150067640 NUP43 0.48 6.7 0.35 8.9e-11 Lung cancer; CRC cis rs2839186 0.508 rs6518278 chr21:47640571 A/G cg00815214 chr21:47717953 NA 0.38 6.26 0.33 1.22e-9 Testicular germ cell tumor; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G ch.7.38331565R chr7:38365040 NA 0.38 6.04 0.32 4.08e-9 Liver disease severity in Alagille syndrome; CRC cis rs78456975 1.000 rs11899027 chr2:1560414 G/C cg26248373 chr2:1572462 NA -0.66 -7.2 -0.37 4.09e-12 Placebo response in major depressive disorder (% change in symptom score); CRC cis rs1499614 1.000 rs60326618 chr7:66166358 G/A cg12463550 chr7:65579703 CRCP 0.64 5.79 0.3 1.66e-8 Gout; CRC cis rs2976388 1.000 rs1045574 chr8:143763958 C/T cg24046110 chr8:143859143 LYNX1 -0.38 -6.63 -0.34 1.36e-10 Urinary tract infection frequency; CRC cis rs4713118 0.539 rs200988 chr6:27819353 A/C cg03623178 chr6:28175578 NA 0.73 10.52 0.5 1.7e-22 Parkinson's disease; CRC cis rs1080500 1.000 rs1080500 chr3:53175017 C/T cg15147215 chr3:52552868 STAB1 -0.51 -7.49 -0.38 6.37e-13 Autism spectrum disorder or schizophrenia; CRC cis rs910316 0.967 rs7146523 chr14:75659880 T/C cg03030879 chr14:75389066 RPS6KL1 0.44 6.77 0.35 6.05e-11 Height; CRC cis rs1223397 1.000 rs1232392 chr6:13272671 C/G cg00460589 chr6:13274354 PHACTR1 0.48 5.92 0.31 8.21e-9 Blood pressure; CRC cis rs8105895 0.935 rs28857211 chr19:22243104 T/C cg02657401 chr19:22469223 NA -0.34 -5.65 -0.3 3.56e-8 Body mass index (change over time); CRC cis rs367943 0.933 rs451453 chr5:112808970 G/C cg12552261 chr5:112820674 MCC -0.5 -7.78 -0.39 9.28e-14 Type 2 diabetes; CRC cis rs78456975 0.527 rs10184112 chr2:1571112 A/G cg26248373 chr2:1572462 NA -0.85 -12.51 -0.57 1.18e-29 Placebo response in major depressive disorder (% change in symptom score); CRC cis rs7618915 0.547 rs11130317 chr3:52731483 C/T cg18404041 chr3:52824283 ITIH1 -0.42 -8.58 -0.43 3.74e-16 Bipolar disorder; CRC cis rs17376456 0.825 rs28705226 chr5:93233135 T/C cg25358565 chr5:93447407 FAM172A 1.05 10.88 0.51 9.17e-24 Diabetic retinopathy; CRC cis rs11958404 0.860 rs72818136 chr5:157462866 C/T cg05962755 chr5:157440814 NA 0.99 12.74 0.57 1.74e-30 IgG glycosylation; CRC cis rs10746514 0.833 rs10864720 chr1:232271232 C/T cg09506761 chr1:232265262 NA -0.46 -6.54 -0.34 2.33e-10 Response to statin therapy; CRC cis rs13191362 1.000 rs36007635 chr6:163009335 G/A cg06582575 chr6:163149167 PACRG;PARK2 0.75 10.24 0.49 1.58e-21 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs2075371 1.000 rs2058976 chr7:133981379 G/T cg02659138 chr7:134003124 SLC35B4 0.37 6.31 0.33 9.06e-10 Mean platelet volume; CRC cis rs1153858 1.000 rs4627277 chr15:45652768 C/A cg14582100 chr15:45693742 SPATA5L1 0.29 6.14 0.32 2.41e-9 Homoarginine levels; CRC cis rs11155671 0.530 rs7763849 chr6:150206380 C/T cg07701084 chr6:150067640 NUP43 0.47 6.82 0.35 4.27e-11 Testicular germ cell tumor; CRC cis rs7274811 0.744 rs2071056 chr20:32265513 A/G cg07470512 chr20:32255052 NECAB3;C20orf134 -0.44 -5.81 -0.31 1.48e-8 Height; CRC cis rs7639513 0.767 rs9861472 chr3:12707776 A/T cg23032965 chr3:12705835 RAF1 -0.65 -9.98 -0.48 1.11e-20 Itch intensity from mosquito bite; CRC cis rs972578 1.000 rs1546861 chr22:43355167 G/A cg01576275 chr22:43409880 NA -0.45 -7.31 -0.37 1.99e-12 Mean platelet volume; CRC cis rs3204270 0.500 rs62077175 chr17:79649568 G/T cg09655341 chr17:79618100 PDE6G 0.56 6.72 0.35 8.17e-11 Dental caries; CRC cis rs10131894 0.611 rs174994 chr14:75434102 A/G cg11812906 chr14:75593930 NEK9 -0.48 -7.2 -0.37 4.15e-12 Coronary artery disease; CRC cis rs34779708 0.966 rs11592567 chr10:35409369 C/T cg03585969 chr10:35415529 CREM 0.66 8.73 0.43 1.33e-16 Inflammatory bowel disease;Crohn's disease; CRC cis rs45509595 0.841 rs2747054 chr6:27783359 A/G cg19041857 chr6:27730383 NA -0.72 -6.75 -0.35 6.7e-11 Breast cancer; CRC cis rs9649213 0.574 rs34830366 chr7:97899535 G/T cg00277769 chr7:97922759 BAIAP2L1 -0.61 -10.54 -0.5 1.4e-22 Prostate cancer (SNP x SNP interaction); CRC cis rs12681288 0.823 rs2701906 chr8:1003316 T/C cg15309053 chr8:964076 NA 0.34 6.01 0.31 4.95e-9 Schizophrenia; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg15470672 chr1:24104458 C1orf128 0.4 5.96 0.31 6.45e-9 Intelligence (multi-trait analysis); CRC cis rs7726839 0.561 rs56410216 chr5:583216 C/A cg14541582 chr5:601475 NA -0.32 -6.65 -0.34 1.22e-10 Obesity-related traits; CRC cis rs9292777 0.897 rs6865484 chr5:40391104 C/T cg09067459 chr5:40385259 NA 0.55 9.76 0.47 6.15e-20 Crohn's disease;Multiple sclerosis; CRC cis rs2882667 0.898 rs6890272 chr5:138371116 G/A cg04439458 chr5:138467593 SIL1 -0.33 -5.99 -0.31 5.58e-9 Age-related hearing impairment (SNP x SNP interaction); CRC trans rs11088226 0.801 rs2833886 chr21:33923872 C/A cg09050820 chr6:167586206 TCP10L2 0.67 8.51 0.42 6.11e-16 Gastritis; CRC cis rs1799949 1.000 rs8176120 chr17:41261233 C/T cg23758822 chr17:41437982 NA 0.79 13.38 0.59 6.65e-33 Menopause (age at onset); CRC trans rs11105468 0.922 rs11105443 chr12:90260446 A/T cg23572944 chr11:60720130 SLC15A3 0.45 6.39 0.33 5.79e-10 Febrile seizures;Febrile seizures (MMR vaccine-related);Febrile seizures (MMR vaccine-unrelated); CRC cis rs2624839 0.602 rs2526390 chr3:50192760 C/T cg05623727 chr3:50126028 RBM5 0.45 6.85 0.35 3.68e-11 Intelligence (multi-trait analysis); CRC cis rs10504229 0.636 rs117439064 chr8:58055279 A/G cg08219700 chr8:58056026 NA 0.53 6.08 0.32 3.31e-9 Developmental language disorder (linguistic errors); CRC cis rs6952808 0.893 rs35487994 chr7:1920171 G/A cg04267008 chr7:1944627 MAD1L1 -0.88 -13.8 -0.61 1.63e-34 Bipolar disorder and schizophrenia; CRC cis rs447 0.806 rs929335 chr7:83744488 C/G cg22846510 chr7:83753280 SEMA3A -0.42 -5.76 -0.3 1.95e-8 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs10504229 0.906 rs58251024 chr8:58172259 G/C cg22535103 chr8:58192502 C8orf71 -0.82 -12.27 -0.56 9.63e-29 Developmental language disorder (linguistic errors); CRC cis rs7705042 0.828 rs10875596 chr5:141495715 T/C cg08523384 chr5:141488047 NDFIP1 -0.34 -5.9 -0.31 9e-9 Asthma; CRC cis rs12477438 0.520 rs4850897 chr2:99768419 A/G cg26064155 chr2:99771622 LIPT1;TSGA10 0.77 12.95 0.58 2.85e-31 Chronic sinus infection; CRC cis rs853679 0.882 rs2743555 chr6:28241081 G/A cg03623178 chr6:28175578 NA 0.73 7.35 0.38 1.57e-12 Depression; CRC cis rs344364 0.511 rs2982455 chr16:1950498 T/G cg03013636 chr16:1946785 NA 0.58 7.09 0.36 8.32e-12 Glomerular filtration rate in chronic kidney disease; CRC cis rs7677751 0.806 rs7698425 chr4:55090656 C/T cg13615338 chr4:55094005 PDGFRA 0.42 6.14 0.32 2.32e-9 Corneal astigmatism; CRC cis rs561341 0.739 rs9906455 chr17:30215669 G/A cg12193833 chr17:30244370 NA 0.44 6.13 0.32 2.59e-9 Hip circumference adjusted for BMI; CRC cis rs9399135 0.660 rs4646868 chr6:135271946 A/G cg22676075 chr6:135203613 NA 0.5 7.67 0.39 1.96e-13 Red blood cell count; CRC cis rs897984 0.759 rs13708 chr16:31000809 G/A cg00531865 chr16:30841666 NA 0.48 6.91 0.36 2.6e-11 Dementia with Lewy bodies; CRC cis rs364477 0.811 rs279895 chr9:967981 C/G cg13952963 chr9:998547 NA -0.57 -6.14 -0.32 2.44e-9 Major depressive disorder; CRC trans rs2243480 0.901 rs58207111 chr7:65486723 C/T cg10756647 chr7:56101905 PSPH 0.77 8.22 0.41 4.72e-15 Diabetic kidney disease; CRC cis rs2832191 0.791 rs28633762 chr21:30500070 C/T cg08807101 chr21:30365312 RNF160 -0.62 -9.68 -0.47 1.16e-19 Dental caries; CRC cis rs826838 1.000 rs6582619 chr12:38729904 A/G cg26384229 chr12:38710491 ALG10B 0.76 10.6 0.5 8.75e-23 Heart rate; CRC trans rs2321882 0.834 rs17682907 chr13:59460631 T/G cg04268950 chr11:130298854 ADAMTS8 -0.45 -5.99 -0.31 5.64e-9 Body mass index; CRC cis rs9916302 0.605 rs12938099 chr17:37612910 T/G cg07936489 chr17:37558343 FBXL20 -0.93 -11.89 -0.55 2.38e-27 Glomerular filtration rate (creatinine); CRC cis rs7703744 0.681 rs17145294 chr5:118701433 G/T cg23985447 chr5:118691066 TNFAIP8 0.44 6.27 0.33 1.15e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs7208859 0.673 rs11658435 chr17:29228561 A/G cg14008862 chr17:28927542 LRRC37B2 0.55 5.75 0.3 2.04e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs8078723 0.701 rs2305482 chr17:38140927 A/C cg17467752 chr17:38218738 THRA -0.55 -8.65 -0.43 2.25e-16 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); CRC cis rs763121 0.853 rs5750633 chr22:38993467 A/G cg06544989 chr22:39130855 UNC84B 0.46 7.43 0.38 9.6e-13 Menopause (age at onset); CRC cis rs58688157 0.705 rs7122021 chr11:595810 A/G cg02461776 chr11:598696 PHRF1 0.46 5.86 0.31 1.14e-8 Systemic lupus erythematosus; CRC cis rs9916302 0.706 rs9908131 chr17:37520449 T/C cg07936489 chr17:37558343 FBXL20 0.91 11.67 0.54 1.4e-26 Glomerular filtration rate (creatinine); CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg07991241 chr10:33269695 NA -0.51 -6.11 -0.32 2.76e-9 Diisocyanate-induced asthma; CRC cis rs951366 0.789 rs823121 chr1:205724302 A/G cg07167872 chr1:205819463 PM20D1 -0.76 -11.59 -0.54 2.74e-26 Menarche (age at onset); CRC cis rs13256369 0.755 rs12550057 chr8:8562268 G/A cg06671706 chr8:8559999 CLDN23 0.62 9.15 0.45 6.16e-18 Obesity-related traits; CRC cis rs10848704 0.637 rs11062351 chr12:2881763 C/T cg19995117 chr12:2880862 NA 0.43 7.79 0.39 8.58e-14 Quantitative traits; CRC cis rs4474465 0.915 rs10899512 chr11:78171338 G/A cg27205649 chr11:78285834 NARS2 -0.45 -5.67 -0.3 3.08e-8 Alzheimer's disease (survival time); CRC cis rs875971 1.000 rs2087647 chr7:65593188 C/A cg18912574 chr7:65842487 NCRNA00174 -0.36 -6.2 -0.32 1.7e-9 Aortic root size; CRC trans rs9291683 0.620 rs11722946 chr4:10125990 A/G cg26043149 chr18:55253948 FECH -0.57 -8.83 -0.44 6.35e-17 Bone mineral density; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg01442104 chr4:159690352 FNIP2 0.44 6.36 0.33 6.93e-10 Intelligence (multi-trait analysis); CRC cis rs7666738 0.724 rs28451676 chr4:98966990 C/T cg05340658 chr4:99064831 C4orf37 0.61 9.45 0.46 6.55e-19 Colonoscopy-negative controls vs population controls; CRC cis rs13191362 1.000 rs13200329 chr6:163004418 G/A cg23758597 chr6:163146217 PARK2 -0.51 -5.91 -0.31 8.33e-9 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs10256972 0.591 rs6950319 chr7:1161324 A/G cg07092213 chr7:1199455 ZFAND2A -0.44 -6.18 -0.32 1.91e-9 Longevity;Endometriosis; CRC cis rs875971 0.862 rs2901152 chr7:65765004 G/A cg18252515 chr7:66147081 NA 0.4 5.63 0.3 3.84e-8 Aortic root size; CRC trans rs459571 0.959 rs2810491 chr9:136923331 C/T cg09836344 chr4:1243392 C4orf42;CTBP1 0.8 11.68 0.54 1.28e-26 Platelet distribution width; CRC cis rs7666738 0.830 rs13134216 chr4:98919765 C/T cg05340658 chr4:99064831 C4orf37 0.59 9.2 0.45 4.15e-18 Colonoscopy-negative controls vs population controls; CRC cis rs7542091 1.000 rs7542091 chr1:210031948 G/C cg21951975 chr1:209979733 IRF6 0.36 6.13 0.32 2.51e-9 Monobrow; CRC cis rs875971 0.505 rs1723275 chr7:65504633 G/C cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.51 -7.64 -0.39 2.44e-13 Aortic root size; CRC cis rs968567 0.705 rs174572 chr11:61598288 C/T cg21709803 chr11:61594965 FADS2 -0.41 -5.67 -0.3 3.15e-8 Blood metabolite levels;Rheumatoid arthritis;Vitiligo;Glycerophospholipid levels; CRC cis rs11971779 0.616 rs10278377 chr7:139103071 G/A cg23387468 chr7:139079360 LUC7L2 0.41 7.05 0.36 1.04e-11 Diisocyanate-induced asthma; CRC cis rs853679 1.000 rs13200462 chr6:28218199 A/C cg15786705 chr6:28176104 NA 0.63 6.13 0.32 2.5e-9 Depression; CRC cis rs7208859 0.725 rs6505215 chr17:29189903 C/A cg13385521 chr17:29058706 SUZ12P 0.55 7.36 0.38 1.53e-12 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs7914558 0.966 rs1591915 chr10:104646849 C/T cg15744005 chr10:104629667 AS3MT -0.33 -7.2 -0.37 4.04e-12 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC trans rs4263408 0.934 rs9683743 chr4:39703194 A/C cg07754938 chr3:48885314 PRKAR2A -0.42 -6.27 -0.33 1.13e-9 Plasma amyloid beta peptide concentrations (ABx-40); CRC trans rs10842750 1.000 rs10842750 chr12:26690565 G/T cg11867950 chr14:31890052 NA 0.52 6.04 0.32 4.19e-9 Kashin-Beck disease; CRC cis rs4481887 0.893 rs1339992 chr1:248509182 G/A cg13385794 chr1:248469461 NA 0.34 6.37 0.33 6.32e-10 Common traits (Other); CRC cis rs12024301 0.557 rs75223998 chr1:183690598 G/T cg11505048 chr1:183622726 RGL1;APOBEC4 0.72 5.63 0.3 3.8e-8 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs1957429 0.901 rs1957432 chr14:65352796 A/G cg23373153 chr14:65346875 NA 0.67 7.25 0.37 2.97e-12 Pediatric areal bone mineral density (radius); CRC cis rs72781680 0.898 rs72782117 chr2:24026921 G/A cg08917208 chr2:24149416 ATAD2B 0.99 9.55 0.47 3.07e-19 Lymphocyte counts; CRC cis rs9462846 1.000 rs2092555 chr6:42863842 C/G cg21280719 chr6:42927975 GNMT -0.31 -5.86 -0.31 1.11e-8 Blood protein levels; CRC cis rs860295 0.702 rs11264387 chr1:155563152 G/T cg02153340 chr1:155202674 NA -0.52 -6.37 -0.33 6.36e-10 Body mass index; CRC cis rs1129187 0.755 rs3818554 chr6:42934620 C/T cg02359409 chr6:42947317 PEX6 -0.67 -11.09 -0.52 1.72e-24 Alzheimer's disease in APOE e4+ carriers; CRC cis rs9747201 0.862 rs11651738 chr17:80178691 A/T cg23141183 chr17:80185318 SLC16A3 0.4 5.62 0.3 4.11e-8 Peripheral arterial disease (traffic-related air pollution interaction); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg16504641 chr6:137143711 PEX7 0.39 6.45 0.34 3.94e-10 Liver disease severity in Alagille syndrome; CRC cis rs1448094 0.842 rs7978562 chr12:86451478 A/G cg02569458 chr12:86230093 RASSF9 0.43 7.31 0.37 2.01e-12 Major depressive disorder; CRC cis rs10540 1.000 rs12418639 chr11:473300 A/C cg03352830 chr11:487213 PTDSS2 -0.63 -7.23 -0.37 3.43e-12 Body mass index; CRC cis rs11711311 0.955 rs9823423 chr3:113419741 A/G cg15478005 chr3:113465772 ATP6V1A;NAA50 0.45 6.1 0.32 2.96e-9 IgG glycosylation; CRC cis rs4713118 0.662 rs149948 chr6:27974817 C/G cg20933634 chr6:27740509 NA 0.43 5.94 0.31 7.3e-9 Parkinson's disease; CRC cis rs425277 0.585 rs2222217 chr1:2063164 G/A cg12639453 chr1:2035780 PRKCZ -0.38 -7.04 -0.36 1.12e-11 Height; CRC cis rs344364 0.602 rs12719796 chr16:1921197 A/G cg09830162 chr16:1889614 FAHD1;C16orf73 0.55 8.31 0.42 2.51e-15 Glomerular filtration rate in chronic kidney disease; CRC cis rs1023500 0.551 rs133371 chr22:42465574 G/A cg25452165 chr22:42524984 CYP2D6 0.39 5.92 0.31 7.9e-9 Schizophrenia; CRC cis rs1552244 1.000 rs76041173 chr3:10078695 G/T cg02579736 chr3:10068473 FANCD2;CIDECP 1.04 13.99 0.61 3.18e-35 Alzheimer's disease; CRC cis rs78456975 0.607 rs73909625 chr2:1541934 A/G cg12573674 chr2:1569213 NA -0.72 -7.28 -0.37 2.42e-12 Placebo response in major depressive disorder (% change in symptom score); CRC cis rs10078 0.571 rs2241597 chr5:480509 A/G cg07599136 chr5:415885 AHRR 0.66 6.87 0.35 3.25e-11 Fat distribution (HIV); CRC cis rs1656402 1.000 rs2077930 chr2:233425867 G/A cg03852847 chr2:233439513 NA 0.45 7.66 0.39 2.12e-13 Non-small cell lung cancer (survival); CRC cis rs9616064 0.506 rs6008944 chr22:47060976 C/T cg05621596 chr22:47072043 GRAMD4 -0.69 -12.11 -0.56 3.58e-28 Urate levels in obese individuals; CRC cis rs3008870 0.920 rs12132532 chr1:67457015 G/T cg08660285 chr1:67390436 MIER1;WDR78 -1.02 -14.64 -0.63 1.01e-37 Lymphocyte percentage of white cells; CRC cis rs3617 0.625 rs2240915 chr3:52859526 T/A cg07507251 chr3:52567010 NT5DC2 0.4 6.22 0.32 1.53e-9 Red blood cell count;Autism spectrum disorder or schizophrenia; CRC cis rs2456568 0.802 rs11020586 chr11:93638547 G/A cg26875233 chr11:93583750 C11orf90 -0.31 -6.03 -0.32 4.38e-9 Response to serotonin reuptake inhibitors in major depressive disorder; CRC trans rs925098 0.577 rs2724470 chr4:17996046 A/G cg05047319 chr11:86748661 TMEM135 -0.43 -6.14 -0.32 2.37e-9 Birth weight;Height; CRC cis rs9303401 0.659 rs7223708 chr17:56896398 A/G cg02118635 chr17:56770003 RAD51C;TEX14 0.77 9.98 0.48 1.15e-20 Cognitive test performance; CRC trans rs11098499 0.954 rs66506550 chr4:120371445 T/A cg25214090 chr10:38739885 LOC399744 0.66 10.47 0.5 2.41e-22 Corneal astigmatism; CRC cis rs910187 0.597 rs2073172 chr20:45809176 A/G cg27589058 chr20:45804311 EYA2 -0.39 -7.52 -0.38 5.3e-13 Migraine; CRC cis rs2486288 0.539 rs2433601 chr15:45716425 T/C cg10760299 chr15:45669010 GATM 0.36 5.65 0.3 3.52e-8 Glomerular filtration rate; CRC cis rs45509595 0.841 rs200501 chr6:27788942 C/T cg15845792 chr6:28175446 NA 0.72 6.15 0.32 2.24e-9 Breast cancer; CRC cis rs13392177 0.684 rs62185965 chr2:219073779 T/C cg00012203 chr2:219082015 ARPC2 -0.49 -7.2 -0.37 4.24e-12 Pyoderma gangrenosum in inflammatory bowel disease; CRC cis rs801193 1.000 rs17566701 chr7:66193183 T/C cg00343986 chr7:65444356 GUSB 0.43 6.2 0.32 1.7e-9 Aortic root size; CRC cis rs2404602 0.692 rs35999717 chr15:77193367 G/C cg03037974 chr15:76606532 NA 0.69 11.52 0.54 5.16e-26 Blood metabolite levels; CRC cis rs4713118 0.662 rs149947 chr6:27972433 A/T cg25164649 chr6:28176230 NA 0.66 9.28 0.46 2.36e-18 Parkinson's disease; CRC cis rs11948739 0.537 rs12518203 chr5:130233745 G/A cg08523029 chr5:130500466 HINT1 -0.47 -6.05 -0.32 3.95e-9 Pediatric bone mineral content (hip); CRC cis rs8044868 0.586 rs7199261 chr16:72082788 A/G cg06172871 chr16:72088244 HP 0.44 6.45 0.33 4.08e-10 Body mass index (change over time) in cancer or chronic obstructive pulmonary disease;Body mass index (change over time) in cancer; CRC cis rs11155671 0.530 rs9371544 chr6:150217360 A/G cg05036130 chr6:150231994 NA 0.28 5.8 0.3 1.53e-8 Testicular germ cell tumor; CRC cis rs881375 0.631 rs2416808 chr9:123706283 G/A cg14255062 chr9:123606675 PSMD5;LOC253039 0.39 6.15 0.32 2.27e-9 Rheumatoid arthritis; CRC cis rs7542091 1.000 rs7542091 chr1:210031948 G/C cg23283495 chr1:209979779 IRF6 0.33 5.97 0.31 6.29e-9 Monobrow; CRC cis rs344364 0.602 rs8044343 chr16:1881145 G/C cg14074117 chr16:1909714 C16orf73 0.36 6.17 0.32 1.98e-9 Glomerular filtration rate in chronic kidney disease; CRC cis rs9915657 0.660 rs12602039 chr17:70089384 A/G cg09344028 chr17:70110421 NA 0.49 7.19 0.37 4.28e-12 Thyroid hormone levels; CRC cis rs9560113 0.508 rs2774425 chr13:112235077 A/G cg10483660 chr13:112241077 NA -0.62 -12.38 -0.56 3.76e-29 Menarche (age at onset); CRC cis rs10504229 0.906 rs66480865 chr8:58187100 C/T cg22535103 chr8:58192502 C8orf71 -0.82 -12.27 -0.56 9.63e-29 Developmental language disorder (linguistic errors); CRC cis rs10751667 0.961 rs7395303 chr11:986221 T/A cg01483505 chr11:975446 AP2A2 0.4 6.1 0.32 2.93e-9 Alzheimer's disease (late onset); CRC cis rs7617773 0.817 rs11130162 chr3:48297611 A/G cg11946769 chr3:48343235 NME6 0.55 7.92 0.4 3.73e-14 Coronary artery disease; CRC cis rs9303280 0.806 rs9907088 chr17:38035116 G/A cg00129232 chr17:37814104 STARD3 -0.43 -6.91 -0.36 2.47e-11 Self-reported allergy; CRC cis rs720844 0.684 rs35154707 chr2:149310951 C/T cg09247360 chr2:149335327 NA -0.56 -5.75 -0.3 2.04e-8 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs1915146 0.967 rs7086481 chr10:126844523 A/T cg23000734 chr10:126850823 CTBP2 -0.64 -10.1 -0.49 4.7e-21 Menarche (age at onset); CRC cis rs2243480 1.000 rs313799 chr7:65494330 A/G cg25985355 chr7:65971099 NA -0.49 -5.65 -0.3 3.51e-8 Diabetic kidney disease; CRC cis rs1322512 0.959 rs1744375 chr6:152944464 C/T cg03415253 chr6:152958462 SYNE1 -0.41 -6.38 -0.33 6.06e-10 Tonometry; CRC cis rs8180040 0.654 rs6791062 chr3:47174343 T/A cg10298567 chr3:47292165 KIF9 -0.38 -6.04 -0.32 4.24e-9 Colorectal cancer; CRC cis rs9372498 0.536 rs9489433 chr6:118867006 G/A cg15382696 chr6:118971807 C6orf204 0.61 7.88 0.4 4.86e-14 Diastolic blood pressure; CRC cis rs7208859 0.623 rs1054397 chr17:29110196 T/C cg01831904 chr17:28903510 LRRC37B2 -0.62 -6.41 -0.33 4.92e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs2882667 0.652 rs700622 chr5:138098551 T/C cg09476006 chr5:138032270 NA -0.56 -9.6 -0.47 2.19e-19 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs7586879 0.639 rs2384058 chr2:25100328 A/G cg04586622 chr2:25135609 ADCY3 -0.55 -10.17 -0.49 2.65e-21 Body mass index; CRC cis rs6540559 0.673 rs926346 chr1:209962204 A/T cg22029157 chr1:209979665 IRF6 0.73 9.51 0.46 4.32e-19 Cleft lip with or without cleft palate; CRC trans rs916888 0.687 rs199456 chr17:44797919 C/T cg22968622 chr17:43663579 NA 1.43 18.91 0.72 1.66e-54 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs7615952 0.733 rs13314847 chr3:125644788 C/T cg05084668 chr3:125655381 ALG1L -0.61 -9.32 -0.46 1.8e-18 Blood pressure (smoking interaction); CRC cis rs12282928 1.000 rs10838840 chr11:48258010 C/A cg20307385 chr11:47447363 PSMC3 0.48 5.91 0.31 8.43e-9 Migraine - clinic-based; CRC cis rs7224685 0.871 rs8081968 chr17:3984117 C/T cg09695851 chr17:3907499 NA 0.54 8.69 0.43 1.8e-16 Type 2 diabetes; CRC cis rs909002 0.962 rs10798883 chr1:32140305 C/T cg13919466 chr1:32135498 COL16A1 -0.4 -7.61 -0.39 2.94e-13 Intelligence (multi-trait analysis); CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg18715716 chr3:52489445 TNNC1;NISCH 0.42 6.0 0.31 5.17e-9 Anxiety disorder; CRC cis rs12900413 0.687 rs10152954 chr15:90307442 T/C cg24249390 chr15:90295951 MESP1 -0.58 -9.15 -0.45 6.26e-18 Coronary artery aneurysm in Kawasaki disease; CRC cis rs73206853 0.764 rs56273026 chr12:110901691 A/C cg12870014 chr12:110450643 ANKRD13A 0.84 9.77 0.47 5.83e-20 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC cis rs951366 0.789 rs1775154 chr1:205696615 T/A cg11965913 chr1:205819406 PM20D1 0.83 13.36 0.59 8.29e-33 Menarche (age at onset); CRC trans rs474558 0.597 rs577834 chr10:99699045 C/T cg05303249 chr11:66036138 RAB1B -0.58 -8.6 -0.43 3.2e-16 Nonsyndromic cleft lip with cleft palate; CRC cis rs7727544 0.716 rs4705928 chr5:131578637 A/G cg09877947 chr5:131593287 PDLIM4 -0.36 -6.38 -0.33 6.11e-10 Blood metabolite levels; CRC cis rs7618915 0.798 rs353547 chr3:52268866 A/G cg18099408 chr3:52552593 STAB1 0.44 6.83 0.35 4.17e-11 Bipolar disorder; CRC trans rs2303319 0.504 rs62189055 chr2:162625749 C/A cg13490827 chr1:46269305 MAST2 -0.69 -6.05 -0.32 4.03e-9 Cognitive function; CRC cis rs11212617 0.837 rs10890822 chr11:108027060 C/A cg12106634 chr11:108092400 ATM;NPAT 0.44 6.56 0.34 2.13e-10 Response to metformin in type 2 diabetes (glycemic); CRC cis rs9905704 0.918 rs12947196 chr17:56902444 G/A cg12560992 chr17:57184187 TRIM37 0.53 7.33 0.37 1.78e-12 Testicular germ cell tumor; CRC cis rs2153535 0.580 rs4451187 chr6:8473910 C/T cg21535247 chr6:8435926 SLC35B3 0.51 7.71 0.39 1.54e-13 Motion sickness; CRC cis rs4727027 0.625 rs75129390 chr7:148846775 T/A cg12479418 chr7:148823350 ZNF425;ZNF398 0.43 5.64 0.3 3.68e-8 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC cis rs1580019 0.665 rs34147895 chr7:32531796 G/C cg14728415 chr7:32535168 LSM5;AVL9 0.45 6.27 0.33 1.14e-9 Cognitive ability; CRC trans rs2303319 0.504 rs56026147 chr2:162614089 T/C cg22627826 chr19:1240265 ATP5D -0.72 -6.24 -0.33 1.32e-9 Cognitive function; CRC cis rs965469 1.000 rs6051753 chr20:3315513 G/A cg25506879 chr20:3388711 C20orf194 -0.39 -5.64 -0.3 3.62e-8 IFN-related cytopenia; CRC trans rs3733585 0.699 rs4621431 chr4:9947590 C/T cg26043149 chr18:55253948 FECH -0.48 -7.0 -0.36 1.43e-11 Cleft plate (environmental tobacco smoke interaction); CRC cis rs6912958 0.781 rs6454632 chr6:88231824 A/C cg12350822 chr6:88032061 C6orf162;GJB7 -0.35 -6.67 -0.34 1.12e-10 Monocyte percentage of white cells; CRC cis rs2033908 0.588 rs1899068 chr11:12872156 A/T cg25843174 chr11:12811716 TEAD1 0.37 6.5 0.34 2.99e-10 Sitting height ratio; CRC cis rs7107770 0.739 rs4936995 chr11:125081694 G/T cg27629782 chr11:125073726 PKNOX2 0.53 7.91 0.4 4.07e-14 Photic sneeze reflex; CRC trans rs1814175 0.781 rs11040681 chr11:49981654 G/T cg21153622 chr11:89784906 NA -0.37 -6.03 -0.32 4.33e-9 Height; CRC cis rs9467773 1.000 rs2224380 chr6:26553943 G/A cg09904177 chr6:26538194 HMGN4 0.85 14.85 0.63 1.61e-38 Intelligence (multi-trait analysis); CRC cis rs3751196 0.808 rs59716163 chr12:104207414 C/T cg02344784 chr12:104178138 NT5DC3 0.71 7.21 0.37 3.94e-12 Sense of smell; CRC cis rs911555 0.755 rs35233301 chr14:103885291 A/G cg24130564 chr14:104152367 KLC1 0.44 5.81 0.31 1.44e-8 Intelligence (multi-trait analysis); CRC trans rs1005277 0.522 rs289645 chr10:37943642 T/C cg17830980 chr10:43048298 ZNF37B -0.39 -6.07 -0.32 3.48e-9 Extrinsic epigenetic age acceleration; CRC cis rs362296 0.511 rs2857861 chr4:3323767 C/T cg08741688 chr4:3415352 RGS12 -0.35 -5.67 -0.3 3.14e-8 Parental longevity (mother's age at death); CRC cis rs1681630 0.545 rs1228001 chr11:47986994 A/T cg05585544 chr11:47624801 NA -0.42 -7.24 -0.37 3.13e-12 Height; CRC cis rs9346649 0.616 rs1873337 chr6:168492160 T/G cg02770688 chr6:168491649 NA 0.61 8.97 0.44 2.24e-17 Venous thromboembolism adjusted for sickle cell variant rs77121243-T; CRC cis rs7772486 0.875 rs9403768 chr6:146406458 A/C cg13319975 chr6:146136371 FBXO30 -0.39 -6.01 -0.31 4.94e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs447735 0.587 rs7188458 chr16:89726484 A/G cg03605463 chr16:89740564 NA 0.45 7.28 0.37 2.51e-12 Hemoglobin concentration; CRC cis rs9039 1.000 rs11862745 chr16:9218887 C/T cg08831531 chr16:9218945 NA 0.63 8.88 0.44 4.4e-17 Menopause (age at onset); CRC cis rs2228479 0.850 rs17226512 chr16:89839976 T/C cg06558623 chr16:89946397 TCF25 1.13 10.76 0.51 2.47e-23 Skin colour saturation; CRC cis rs9894429 0.608 rs7406219 chr17:79609410 G/T cg21028142 chr17:79581711 NPLOC4 0.34 7.1 0.36 7.88e-12 Eye color traits; CRC cis rs4730250 0.595 rs7789500 chr7:106915723 A/C cg23293999 chr7:106826042 HBP1 -0.54 -5.71 -0.3 2.52e-8 Osteoarthritis; CRC cis rs17376456 0.877 rs10062711 chr5:93348659 G/A cg21475434 chr5:93447410 FAM172A 0.79 7.91 0.4 4.03e-14 Diabetic retinopathy; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg07631383 chr7:131012765 MKLN1 0.45 6.52 0.34 2.69e-10 Intelligence (multi-trait analysis); CRC cis rs2797160 1.000 rs6933302 chr6:126016951 T/C cg05901451 chr6:126070800 HEY2 0.39 6.06 0.32 3.66e-9 Endometrial cancer; CRC cis rs7811142 0.830 rs6945952 chr7:99981775 A/G cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.11 16.03 0.66 3.87e-43 Platelet count; CRC trans rs11039798 0.623 rs635632 chr11:48399532 T/C cg15704280 chr7:45808275 SEPT13 -0.66 -6.94 -0.36 2.15e-11 Axial length; CRC cis rs4819052 0.851 rs4819038 chr21:46659393 C/T cg19498844 chr21:46707878 POFUT2;LOC642852 0.77 10.99 0.52 3.97e-24 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs7258465 1.000 rs10427083 chr19:18550276 C/A cg10790698 chr19:18539756 SSBP4 -0.46 -8.72 -0.43 1.44e-16 Breast cancer; CRC cis rs4727027 0.870 rs1105261 chr7:148794442 T/G cg12479418 chr7:148823350 ZNF425;ZNF398 0.44 5.96 0.31 6.56e-9 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg19935506 chr2:242626874 DTYMK 0.43 6.05 0.32 3.94e-9 Response to antipsychotic treatment; CRC cis rs4889855 0.614 rs9892081 chr17:78484484 A/C cg16591659 chr17:78472290 NA 0.47 6.17 0.32 2.02e-9 Fractional excretion of uric acid; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg04582424 chr1:203764710 ZC3H11A -0.47 -6.68 -0.35 1.03e-10 Myopia (pathological); CRC cis rs6963495 0.818 rs117845382 chr7:105152040 T/C cg13798780 chr7:105162888 PUS7 0.67 7.93 0.4 3.42e-14 Bipolar disorder (body mass index interaction); CRC cis rs57590327 0.528 rs2229519 chr3:81698130 T/C cg07356753 chr3:81810745 GBE1 -0.65 -8.55 -0.43 4.85e-16 Extraversion; CRC cis rs28386778 0.897 rs4968662 chr17:61834537 A/G cg07362569 chr17:61921086 SMARCD2 0.37 5.73 0.3 2.27e-8 Prudent dietary pattern; CRC cis rs11098499 0.863 rs1480936 chr4:120462861 C/T cg09307838 chr4:120376055 NA 0.67 10.34 0.5 6.89e-22 Corneal astigmatism; CRC cis rs67311347 1.000 rs6762251 chr3:40531136 A/G cg09455208 chr3:40491958 NA -0.41 -8.0 -0.4 2.2e-14 Renal cell carcinoma; CRC cis rs9314323 0.798 rs2019239 chr8:26217354 G/A cg13160058 chr8:26243215 BNIP3L -0.46 -7.82 -0.4 7.06e-14 Red cell distribution width; CRC cis rs55788414 1.000 rs34242559 chr16:81180138 T/C cg06400318 chr16:81190750 PKD1L2 -0.68 -6.38 -0.33 5.87e-10 Left ventricular obstructive tract defect (maternal effect); CRC cis rs853679 0.517 rs9357066 chr6:28129831 T/C cg15845792 chr6:28175446 NA 1.04 13.89 0.61 7.67e-35 Depression; CRC cis rs7113874 0.589 rs10840056 chr11:8498064 A/C cg02811074 chr11:8615871 STK33 0.36 6.15 0.32 2.24e-9 Body mass index in physically active individuals;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs910316 0.967 rs2010678 chr14:75567178 C/T cg11812906 chr14:75593930 NEK9 0.64 10.38 0.5 4.88e-22 Height; CRC cis rs12458462 0.892 rs3786228 chr18:77464170 C/T cg11879182 chr18:77439856 CTDP1 -0.73 -11.4 -0.53 1.34e-25 Monocyte count; CRC cis rs7208859 0.623 rs77544470 chr17:28934550 C/A cg01831904 chr17:28903510 LRRC37B2 -0.61 -6.09 -0.32 3.13e-9 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs7666738 0.716 rs28792413 chr4:99083707 G/A cg05340658 chr4:99064831 C4orf37 0.51 7.61 0.39 2.83e-13 Colonoscopy-negative controls vs population controls; CRC cis rs10992471 0.597 rs11789163 chr9:95234973 T/C cg13798575 chr9:95087839 CENPP;NOL8 -0.4 -5.87 -0.31 1.07e-8 Visceral adipose tissue/subcutaneous adipose tissue ratio; CRC cis rs7772486 0.719 rs702307 chr6:145993454 C/G cg05347473 chr6:146136440 FBXO30 -0.4 -5.97 -0.31 6.26e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs6963495 0.818 rs116845562 chr7:105217038 T/C cg13798780 chr7:105162888 PUS7 0.64 7.39 0.38 1.2e-12 Bipolar disorder (body mass index interaction); CRC trans rs1455244 0.700 rs7229302 chr18:11508904 G/T cg12698737 chr15:69110455 ANP32A 0.46 6.93 0.36 2.28e-11 Schizophrenia; CRC cis rs2346177 0.542 rs718849 chr2:46698116 G/A cg02822958 chr2:46747628 ATP6V1E2 0.4 5.74 0.3 2.19e-8 HDL cholesterol; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg08245420 chr5:139726438 HBEGF 0.5 7.3 0.37 2.23e-12 Response to antipsychotic treatment; CRC cis rs172166 0.769 rs149965 chr6:28018689 T/A cg25164649 chr6:28176230 NA 0.59 8.31 0.42 2.63e-15 Cardiac Troponin-T levels; CRC cis rs13118159 0.872 rs4974604 chr4:1345798 T/C cg15763984 chr4:1342303 KIAA1530 0.35 5.99 0.31 5.49e-9 Longevity; CRC trans rs61931739 0.517 rs7313663 chr12:34417058 T/C cg26384229 chr12:38710491 ALG10B 0.6 8.89 0.44 4.13e-17 Morning vs. evening chronotype; CRC cis rs7914558 0.966 rs2065977 chr10:104729415 C/T cg15744005 chr10:104629667 AS3MT -0.34 -7.4 -0.38 1.12e-12 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs9915657 0.595 rs10438697 chr17:70055734 A/G cg09344028 chr17:70110421 NA -0.49 -7.47 -0.38 7.23e-13 Thyroid hormone levels; CRC cis rs10028773 0.556 rs4473640 chr4:120260437 G/A cg09307838 chr4:120376055 NA 0.6 9.53 0.47 3.52e-19 Educational attainment; CRC trans rs7395662 0.534 rs12418219 chr11:48988091 G/T cg00717180 chr2:96193071 NA -0.39 -6.33 -0.33 8.02e-10 HDL cholesterol; CRC cis rs1784581 0.761 rs7741581 chr6:162435250 C/T cg17173639 chr6:162384350 PARK2 0.67 11.03 0.52 2.84e-24 Itch intensity from mosquito bite; CRC cis rs3096299 0.933 rs3114848 chr16:89452771 G/A cg01788221 chr16:89496183 ANKRD11 -0.41 -6.26 -0.33 1.17e-9 Multiple myeloma (IgH translocation); CRC cis rs798554 0.797 rs798494 chr7:2798294 C/A cg19346786 chr7:2764209 NA -0.39 -6.79 -0.35 5.31e-11 Height; CRC cis rs9814567 1.000 rs6439487 chr3:134260860 G/A cg06109529 chr3:134205091 CEP63;ANAPC13 -0.81 -12.19 -0.56 1.92e-28 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs9308731 0.644 rs7593638 chr2:111876941 A/C cg04202892 chr2:111875749 ACOXL 0.47 7.76 0.39 1.05e-13 Chronic lymphocytic leukemia; CRC cis rs3806843 1.000 rs13184940 chr5:140172918 T/C cg16607685 chr5:140181889 PCDHA2;PCDHA1;PCDHA3 -0.26 -5.97 -0.31 6.06e-9 Depressive symptoms (multi-trait analysis); CRC trans rs7395662 1.000 rs12419576 chr11:48581644 T/C cg21153622 chr11:89784906 NA -0.46 -7.31 -0.37 2.06e-12 HDL cholesterol; CRC cis rs6502050 0.842 rs9894129 chr17:80075700 A/G cg25804541 chr17:80189381 SLC16A3 0.32 6.13 0.32 2.51e-9 Life satisfaction; CRC cis rs7461897 0.511 rs1383916 chr8:26825245 A/G cg06816054 chr8:27695695 PBK -0.57 -5.8 -0.3 1.58e-8 Epilepsy and lamotrigine-induced maculopapular eruptions; CRC cis rs9649213 0.593 rs10808107 chr7:97951671 T/C cg00277769 chr7:97922759 BAIAP2L1 -0.61 -10.63 -0.51 6.86e-23 Prostate cancer (SNP x SNP interaction); CRC cis rs76878669 0.561 rs2279861 chr11:66133336 A/G cg24851651 chr11:66362959 CCS -0.38 -6.71 -0.35 8.65e-11 Educational attainment (years of education); CRC cis rs250677 0.687 rs250678 chr5:148434830 C/T cg18129178 chr5:148520854 ABLIM3 -0.36 -5.67 -0.3 3.2e-8 Breast cancer; CRC cis rs4780401 0.609 rs11639945 chr16:11824056 T/G cg01061890 chr16:11836724 TXNDC11 -0.55 -7.9 -0.4 4.17e-14 Rheumatoid arthritis; CRC cis rs2952156 0.959 rs2941503 chr17:37828745 A/G cg20243544 chr17:37824526 PNMT 0.57 8.88 0.44 4.54e-17 Asthma; CRC cis rs12200560 0.505 rs927271 chr6:97075910 T/G cg06623918 chr6:96969491 KIAA0776 0.49 7.29 0.37 2.39e-12 Coronary heart disease; CRC cis rs2976388 0.647 rs2585136 chr8:143812141 A/G cg15511327 chr8:143859410 LYNX1 0.41 7.21 0.37 3.96e-12 Urinary tract infection frequency; CRC cis rs10927875 0.619 rs7537101 chr1:16150384 T/C cg21385522 chr1:16154831 NA -0.8 -13.46 -0.6 3.46e-33 Dilated cardiomyopathy; CRC cis rs9393777 0.920 rs13191227 chr6:27390115 G/C cg26958806 chr6:27640298 NA 0.93 6.09 0.32 3.08e-9 Intelligence (multi-trait analysis); CRC cis rs4481887 0.861 rs4644528 chr1:248472508 T/A cg13385794 chr1:248469461 NA 0.38 6.75 0.35 6.84e-11 Common traits (Other); CRC cis rs4664308 0.870 rs1870104 chr2:161032285 A/G cg03641300 chr2:160917029 PLA2R1 -0.72 -12.09 -0.55 4.33e-28 Idiopathic membranous nephropathy; CRC cis rs17376456 0.877 rs10057814 chr5:93399092 C/G cg21475434 chr5:93447410 FAM172A 0.74 7.9 0.4 4.3e-14 Diabetic retinopathy; CRC cis rs225245 0.817 rs225273 chr17:33970935 A/T cg05299278 chr17:33885742 SLFN14 0.48 7.94 0.4 3.13e-14 Reticulocyte count;Reticulocyte fraction of red cells;High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells; CRC cis rs853679 0.517 rs55747925 chr6:28044337 T/C cg03623178 chr6:28175578 NA 0.93 12.26 0.56 9.88e-29 Depression; CRC cis rs1475911 1.000 rs34421316 chr21:43513989 C/T cg19766460 chr21:43528205 UMODL1;C21orf128 0.63 7.25 0.37 2.97e-12 IgG glycosylation; CRC cis rs35110281 0.511 rs2298562 chr21:45085236 A/G cg01579765 chr21:45077557 HSF2BP -0.36 -6.93 -0.36 2.26e-11 Mean corpuscular volume; CRC cis rs9443645 0.901 rs1890229 chr6:79695029 C/T cg11833968 chr6:79620685 NA -0.36 -6.09 -0.32 3.08e-9 Intelligence (multi-trait analysis); CRC cis rs10504229 0.815 rs55855654 chr8:58164299 T/G cg21724239 chr8:58056113 NA 0.65 8.48 0.42 7.95e-16 Developmental language disorder (linguistic errors); CRC cis rs67478160 0.643 rs6575999 chr14:104250609 C/G cg08213375 chr14:104286397 PPP1R13B 0.64 13.18 0.59 3.93e-32 Schizophrenia; CRC cis rs9611565 0.512 rs2899347 chr22:42158204 T/C cg06634786 chr22:41940651 POLR3H 0.65 7.08 0.36 8.93e-12 Vitiligo; CRC cis rs3785574 0.962 rs35448669 chr17:61938923 G/A cg22520471 chr17:61851767 DDX42;CCDC47 0.43 5.92 0.31 8.08e-9 Height; CRC cis rs2370759 1.000 rs79578760 chr10:32611264 C/A cg01819863 chr10:32635814 EPC1 1.1 12.91 0.58 3.82e-31 Sexual dysfunction (female); CRC cis rs9926296 0.572 rs2376878 chr16:89885161 G/A cg04287289 chr16:89883240 FANCA 0.65 11.08 0.52 1.83e-24 Vitiligo; CRC cis rs1005277 0.579 rs1740745 chr10:38520056 T/C cg25517755 chr10:38738941 LOC399744 -0.41 -5.92 -0.31 8.23e-9 Extrinsic epigenetic age acceleration; CRC cis rs7487075 0.820 rs7134855 chr12:46711310 A/G cg22049899 chr12:47219821 SLC38A4 0.34 6.54 0.34 2.31e-10 Itch intensity from mosquito bite; CRC cis rs17376456 0.877 rs10064520 chr5:93427358 T/C cg25358565 chr5:93447407 FAM172A 1.02 10.38 0.5 4.9e-22 Diabetic retinopathy; CRC trans rs6544773 0.668 rs2673280 chr2:45065353 G/A cg10208897 chr5:178548229 ADAMTS2 0.35 6.12 0.32 2.59e-9 Mosquito bite size; CRC cis rs7618915 0.570 rs4687633 chr3:52630548 G/A cg15147215 chr3:52552868 STAB1 -0.61 -10.13 -0.49 3.53e-21 Bipolar disorder; CRC cis rs514406 0.929 rs562178 chr1:53319562 T/C cg24675658 chr1:53192096 ZYG11B -0.54 -8.21 -0.41 5.22e-15 Monocyte count; CRC cis rs7524258 0.900 rs12035586 chr1:7273020 C/T cg07173049 chr1:7289937 CAMTA1 -0.51 -8.21 -0.41 5.26e-15 Tourette's syndrome or obsessive-compulsive disorder; CRC trans rs2303319 0.504 rs62188147 chr2:162286552 G/T cg04145477 chr6:107077629 RTN4IP1;QRSL1 -0.84 -6.46 -0.34 3.79e-10 Cognitive function; CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg26515694 chr19:21949968 ZNF100 0.34 6.43 0.33 4.6e-10 Obesity-related traits; CRC cis rs853679 0.550 rs1150689 chr6:28165099 T/C cg06470822 chr6:28175283 NA 1.01 15.38 0.65 1.29e-40 Depression; CRC cis rs10504229 1.000 rs56168206 chr8:58184485 G/A cg02290350 chr8:58132656 NA -0.42 -5.96 -0.31 6.62e-9 Developmental language disorder (linguistic errors); CRC cis rs6831352 0.744 rs2602847 chr4:100025963 T/C cg13256891 chr4:100009986 ADH5 0.63 8.56 0.43 4.54e-16 Alcohol dependence; CRC trans rs7829975 0.514 rs2976929 chr8:8258712 T/C cg16141378 chr3:129829833 LOC729375 -0.52 -7.68 -0.39 1.8e-13 Mood instability; CRC cis rs7945705 0.747 rs2742480 chr11:8993130 A/G cg12365402 chr11:9010492 NRIP3 -0.61 -11.48 -0.53 7.05e-26 Hemoglobin concentration; CRC cis rs854765 0.547 rs4584886 chr17:17896205 C/T cg09796270 chr17:17721594 SREBF1 0.46 7.97 0.4 2.58e-14 Total body bone mineral density; CRC cis rs9611565 0.527 rs73178638 chr22:41942904 T/C cg06634786 chr22:41940651 POLR3H -0.71 -8.16 -0.41 7.27e-15 Vitiligo; CRC cis rs17067123 0.614 rs7340789 chr4:180052417 C/T cg26610307 chr4:180072759 NA -0.54 -6.5 -0.34 3.01e-10 Response to hepatitis C treatment; CRC trans rs8123881 0.733 rs7268466 chr20:15810676 C/T cg16471585 chr12:118199103 KSR2 -0.59 -6.86 -0.35 3.34e-11 Body mass index; CRC cis rs6502050 0.736 rs11658040 chr17:80059891 C/T cg22110888 chr17:80059540 CCDC57 -0.45 -6.96 -0.36 1.9e-11 Life satisfaction; CRC cis rs10760158 0.832 rs3810942 chr9:124044995 C/T cg14417974 chr9:124058376 GSN -0.34 -5.83 -0.31 1.32e-8 Pulse pressure; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg23831110 chr14:102785987 ZNF839 0.39 6.14 0.32 2.43e-9 Liver disease severity in Alagille syndrome; CRC cis rs6500602 0.701 rs8129 chr16:4562351 A/G cg13763550 chr16:4524223 NMRAL1;HMOX2 0.47 6.26 0.33 1.23e-9 Schizophrenia; CRC cis rs10504229 0.728 rs72650853 chr8:58151473 G/A cg22535103 chr8:58192502 C8orf71 -0.68 -8.37 -0.42 1.72e-15 Developmental language disorder (linguistic errors); CRC cis rs6502050 0.835 rs11077981 chr17:80147243 C/T cg22110888 chr17:80059540 CCDC57 0.4 6.24 0.33 1.33e-9 Life satisfaction; CRC cis rs17433780 0.964 rs12121223 chr1:89481583 C/T cg09516651 chr1:89888402 LOC400759 0.49 7.19 0.37 4.26e-12 Carotid intima media thickness; CRC cis rs10504229 0.679 rs111843870 chr8:58126798 A/G cg24829409 chr8:58192753 C8orf71 -0.55 -8.03 -0.4 1.71e-14 Developmental language disorder (linguistic errors); CRC cis rs1552244 0.882 rs17050672 chr3:10025463 G/A cg00166722 chr3:10149974 C3orf24 0.61 7.53 0.38 4.98e-13 Alzheimer's disease; CRC trans rs11098499 0.954 rs10024844 chr4:120311528 A/G cg25214090 chr10:38739885 LOC399744 0.62 9.74 0.47 7.35e-20 Corneal astigmatism; CRC cis rs3796352 1.000 rs13072395 chr3:52980573 T/C cg06204229 chr3:52865917 ITIH4 0.52 5.86 0.31 1.13e-8 Immune reponse to smallpox (secreted IL-2); CRC cis rs2386661 0.826 rs7092383 chr10:5671101 A/C cg26603656 chr10:5671107 NA 0.55 9.1 0.45 8.84e-18 Breast cancer; CRC cis rs11122272 0.735 rs2437149 chr1:231490105 C/T cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.5 -7.37 -0.38 1.43e-12 Hemoglobin concentration; CRC cis rs6764363 0.527 rs12496555 chr3:278154 A/G cg02057681 chr3:285234 CHL1 0.42 7.11 0.37 7.08e-12 Sudden cardiac arrest; CRC cis rs7208859 0.673 rs73263776 chr17:29211331 G/C cg01831904 chr17:28903510 LRRC37B2 -0.54 -5.65 -0.3 3.39e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg03372779 chr16:2069785 NPW 0.34 6.37 0.33 6.25e-10 Liver disease severity in Alagille syndrome; CRC trans rs951252 0.504 rs11734405 chr4:146081096 C/T cg19429466 chr4:87515395 PTPN13 0.44 6.4 0.33 5.23e-10 Hip circumference; CRC cis rs6952808 0.893 rs35487994 chr7:1920171 G/A cg20295408 chr7:1910781 MAD1L1 -0.45 -6.32 -0.33 8.34e-10 Bipolar disorder and schizophrenia; CRC cis rs11098499 0.542 rs7677836 chr4:120310638 T/A cg09307838 chr4:120376055 NA 0.71 10.93 0.52 6.41e-24 Corneal astigmatism; CRC cis rs10504229 0.683 rs6980850 chr8:58127204 A/G cg04204079 chr8:58130323 NA -0.45 -5.78 -0.3 1.71e-8 Developmental language disorder (linguistic errors); CRC cis rs2354432 0.505 rs7551766 chr1:146858964 A/G cg25205988 chr1:146714368 CHD1L -1.25 -10.18 -0.49 2.44e-21 Mitochondrial DNA levels; CRC trans rs66573146 0.831 rs68111914 chr4:6986677 C/T cg07817883 chr1:32538562 TMEM39B 1.32 12.64 0.57 3.95e-30 Granulocyte percentage of myeloid white cells; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg13674574 chr14:64971270 ZBTB25;ZBTB1 0.38 5.97 0.31 6.21e-9 Intelligence (multi-trait analysis); CRC trans rs11581859 0.950 rs72730322 chr1:99384244 T/C cg12183875 chr3:169587454 LRRC31 0.28 6.36 0.33 6.89e-10 Response to cognitive-behavioural therapy in anxiety disorder; CRC cis rs561341 1.000 rs72825740 chr17:30338356 A/G cg19193384 chr17:30244184 NA -0.65 -7.54 -0.38 4.67e-13 Hip circumference adjusted for BMI; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg15441325 chr3:106959341 LOC344595;LOC100302640 0.42 6.0 0.31 5.2e-9 Response to antipsychotic treatment; CRC cis rs11585357 0.895 rs72646797 chr1:17613838 C/G cg08277548 chr1:17600880 PADI3 -0.89 -11.28 -0.53 3.61e-25 Hair shape; CRC cis rs1862618 0.756 rs13356762 chr5:56110992 G/T cg03609598 chr5:56110824 MAP3K1 -0.83 -10.04 -0.48 7.11e-21 Initial pursuit acceleration; CRC cis rs7811142 0.830 rs77861211 chr7:99962096 T/C cg00814883 chr7:100076585 TSC22D4 -0.7 -8.85 -0.44 5.49e-17 Platelet count; CRC cis rs2398893 0.924 rs7855830 chr9:96798659 A/G cg14459158 chr9:96720562 NA 0.4 6.62 0.34 1.42e-10 Waist-hip ratio;Waist-to-hip ratio adjusted for body mass index; CRC cis rs6087990 0.899 rs998382 chr20:31384136 C/T cg13636640 chr20:31349939 DNMT3B -0.82 -17.2 -0.69 9.78e-48 Ulcerative colitis; CRC cis rs2354432 0.607 rs12404113 chr1:146750343 C/A cg25205988 chr1:146714368 CHD1L -1.13 -9.56 -0.47 2.83e-19 Mitochondrial DNA levels; CRC cis rs13108904 0.840 rs3915420 chr4:1260337 T/C cg02018176 chr4:1364513 KIAA1530 0.45 7.42 0.38 1.01e-12 Obesity-related traits; CRC cis rs13256369 0.865 rs13282523 chr8:8577293 C/G cg06636001 chr8:8085503 FLJ10661 0.48 6.43 0.33 4.48e-10 Obesity-related traits; CRC cis rs10540 0.908 rs12792111 chr11:520921 G/C cg21784768 chr11:537496 LRRC56 -0.7 -6.64 -0.34 1.32e-10 Body mass index; CRC cis rs904251 0.797 rs1776460 chr6:37485484 A/G cg25019722 chr6:37503610 NA -0.48 -8.87 -0.44 4.78e-17 Cognitive performance; CRC cis rs10924970 0.687 rs61836127 chr1:235363740 T/G cg09010748 chr1:235293032 TOMM20 -0.43 -5.91 -0.31 8.38e-9 Asthma; CRC cis rs728616 0.867 rs17606361 chr10:81845411 G/C cg05935833 chr10:81318306 SFTPA2 -0.61 -6.95 -0.36 1.97e-11 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs875971 0.862 rs6947339 chr7:65888470 T/C cg18252515 chr7:66147081 NA -0.42 -6.0 -0.31 5.21e-9 Aortic root size; CRC cis rs4727027 0.899 rs6944096 chr7:148870026 A/G cg23583168 chr7:148888333 NA -0.98 -18.29 -0.71 4.52e-52 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC cis rs35883536 0.647 rs11166485 chr1:101048805 G/C cg06223162 chr1:101003688 GPR88 -0.34 -6.1 -0.32 2.96e-9 Monocyte count; CRC cis rs9847710 0.683 rs2581818 chr3:53071652 C/A cg18099408 chr3:52552593 STAB1 0.39 5.83 0.31 1.3e-8 Ulcerative colitis; CRC cis rs7909074 1.000 rs10751361 chr10:45398186 C/A cg05187965 chr10:45406764 TMEM72 -0.36 -8.21 -0.41 5.12e-15 Mean corpuscular volume; CRC cis rs6502050 0.835 rs35857672 chr17:80078303 G/A cg02741985 chr17:80059408 CCDC57 -0.44 -7.2 -0.37 4.13e-12 Life satisfaction; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg11471666 chr12:53400335 EIF4B 0.45 6.48 0.34 3.39e-10 Response to antipsychotic treatment; CRC trans rs1997103 0.954 rs6593236 chr7:55410992 C/T cg20935933 chr6:143382018 AIG1 0.55 7.05 0.36 1.04e-11 QRS interval (sulfonylurea treatment interaction); CRC cis rs9372498 0.536 rs9489452 chr6:118910868 G/C cg07617317 chr6:118971624 C6orf204 0.49 6.16 0.32 2.17e-9 Diastolic blood pressure; CRC cis rs7959452 0.684 rs11177615 chr12:69754189 G/A cg20891283 chr12:69753455 YEATS4 0.88 16.0 0.66 5e-43 Blood protein levels; CRC cis rs17666538 0.585 rs336444 chr8:633123 C/G cg23958373 chr8:599963 NA -0.65 -7.06 -0.36 1.01e-11 IgG glycosylation; CRC cis rs9660180 0.935 rs9786942 chr1:1759213 A/G cg23982607 chr1:1823379 GNB1 -0.88 -15.57 -0.65 2.54e-41 Body mass index; CRC cis rs12023718 0.588 rs16853133 chr1:178602237 C/G cg00404053 chr1:178313656 RASAL2 -0.63 -7.84 -0.4 6.21e-14 Obesity-related traits; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg08125682 chr16:11038455 CLEC16A 0.46 7.78 0.39 9.76e-14 Liver disease severity in Alagille syndrome; CRC cis rs35883536 1.000 rs1932351 chr1:101142049 C/T cg14515779 chr1:101123966 NA -0.43 -8.31 -0.42 2.46e-15 Monocyte count; CRC cis rs4363385 0.693 rs1933384 chr1:152959488 A/T cg25856811 chr1:152973957 SPRR3 -0.26 -7.29 -0.37 2.3e-12 Inflammatory skin disease; CRC cis rs13315871 0.929 rs1554124 chr3:58268968 C/G cg20936604 chr3:58311152 NA -0.64 -5.97 -0.31 6.1e-9 Cholesterol, total; CRC cis rs995000 0.965 rs11207982 chr1:63007182 C/T cg19896129 chr1:63156450 NA 0.4 5.83 0.31 1.29e-8 Triglyceride levels; CRC cis rs6961069 0.806 rs10499859 chr7:80258810 A/G cg04458919 chr7:80252533 CD36 0.35 6.05 0.32 3.95e-9 Platelet count; CRC cis rs295140 0.507 rs13019821 chr2:201106815 C/G cg23649088 chr2:200775458 C2orf69 -0.4 -5.75 -0.3 2e-8 QT interval; CRC trans rs925098 0.577 rs2724470 chr4:17996046 A/G cg03909902 chr12:108154529 PRDM4 -0.44 -6.56 -0.34 2.1e-10 Birth weight;Height; CRC cis rs6880778 0.505 rs6891041 chr5:40406238 G/A cg09067459 chr5:40385259 NA 0.46 7.69 0.39 1.71e-13 Inflammatory bowel disease; CRC cis rs6960043 1.000 rs6972333 chr7:15051643 G/A cg19272540 chr7:15055459 NA -0.22 -5.75 -0.3 2.03e-8 Type 2 diabetes; CRC cis rs1552244 0.515 rs111560858 chr3:10166845 G/A cg16606324 chr3:10149918 C3orf24 0.66 7.72 0.39 1.45e-13 Alzheimer's disease; CRC cis rs477692 0.905 rs508360 chr10:131424969 A/G cg26102564 chr10:131424627 MGMT 0.39 5.68 0.3 2.91e-8 Response to temozolomide; CRC cis rs3733585 0.673 rs7377578 chr4:9952775 T/C cg00071950 chr4:10020882 SLC2A9 -0.55 -9.74 -0.47 7.09e-20 Cleft plate (environmental tobacco smoke interaction); CRC cis rs2019137 0.560 rs10206269 chr2:113990393 C/A cg09704166 chr2:114031854 PAX8;LOC440839 -0.38 -7.08 -0.36 9.03e-12 Lymphocyte counts; CRC cis rs2019137 0.868 rs3748916 chr2:113984033 C/T cg21482265 chr2:113992762 PAX8;LOC440839;LOC654433 -0.47 -6.69 -0.35 9.51e-11 Lymphocyte counts; CRC cis rs758324 0.812 rs667437 chr5:131275509 C/T cg25547332 chr5:131281432 NA -0.36 -5.72 -0.3 2.46e-8 Alzheimer's disease in APOE e4- carriers; CRC cis rs3008870 0.959 rs3008852 chr1:67383416 G/A cg08660285 chr1:67390436 MIER1;WDR78 1.04 16.07 0.66 2.57e-43 Lymphocyte percentage of white cells; CRC cis rs6502050 0.805 rs9898326 chr17:80119582 C/T cg09264619 chr17:80180166 NA -0.35 -5.93 -0.31 7.47e-9 Life satisfaction; CRC cis rs910316 0.935 rs175076 chr14:75505486 A/G cg08847533 chr14:75593920 NEK9 -0.91 -17.23 -0.69 7.38e-48 Height; CRC trans rs7580658 0.614 rs7585198 chr2:127962635 C/T cg20503117 chr3:5164013 ARL8B -0.46 -6.21 -0.32 1.56e-9 Protein C levels; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg27306034 chr1:155224863 FAM189B 0.4 6.53 0.34 2.49e-10 Liver disease severity in Alagille syndrome; CRC cis rs10504229 0.683 rs11786523 chr8:58131319 G/C cg04204079 chr8:58130323 NA -0.45 -5.78 -0.3 1.71e-8 Developmental language disorder (linguistic errors); CRC cis rs4332037 0.539 rs56180486 chr7:2050747 C/T cg25834613 chr7:1915315 MAD1L1 -0.45 -6.29 -0.33 1.02e-9 Bipolar disorder; CRC cis rs7943191 0.805 rs12226821 chr11:62369018 C/G cg13298116 chr11:62369859 EML3;MTA2 0.56 8.98 0.44 2.11e-17 Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction); CRC trans rs1814175 0.650 rs6486000 chr11:49659090 T/A cg15704280 chr7:45808275 SEPT13 -0.87 -14.25 -0.62 3.16e-36 Height; CRC cis rs12620999 0.941 rs2875690 chr2:237977737 G/A cg23555395 chr2:238036564 NA 0.52 8.12 0.41 9.17e-15 Systemic lupus erythematosus; CRC cis rs17532515 0.628 rs3113196 chr4:141477273 T/C cg09181644 chr4:141490428 UCP1 0.33 5.98 0.31 5.91e-9 Select biomarker traits; CRC cis rs9649213 0.593 rs36017146 chr7:97974617 C/T cg21770322 chr7:97807741 LMTK2 0.52 8.58 0.43 3.88e-16 Prostate cancer (SNP x SNP interaction); CRC cis rs775227 0.528 rs775231 chr3:113027214 A/C cg18753928 chr3:113234510 CCDC52 0.51 7.11 0.36 7.46e-12 Dental caries; CRC cis rs231513 1.000 rs231519 chr17:41961051 C/T cg26893861 chr17:41843967 DUSP3 0.68 6.81 0.35 4.57e-11 Cognitive function; CRC cis rs9322193 0.962 rs9322218 chr6:150103319 A/G cg07701084 chr6:150067640 NUP43 0.47 6.72 0.35 8.19e-11 Lung cancer; CRC cis rs10751667 0.621 rs4075990 chr11:976614 T/C ch.11.42038R chr11:967971 AP2A2 0.58 9.98 0.48 1.16e-20 Alzheimer's disease (late onset); CRC cis rs17345786 0.798 rs9817043 chr3:101281852 A/G cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.47 5.78 0.3 1.78e-8 Colonoscopy-negative controls vs population controls; CRC cis rs2050392 0.517 rs302423 chr10:30772513 A/G cg25182066 chr10:30743637 MAP3K8 -0.59 -8.29 -0.42 2.99e-15 Inflammatory bowel disease; CRC trans rs7395662 1.000 rs4882015 chr11:48565573 A/T cg21153622 chr11:89784906 NA -0.47 -7.58 -0.39 3.59e-13 HDL cholesterol; CRC cis rs763121 0.853 rs5757166 chr22:38995385 G/T cg06022373 chr22:39101656 GTPBP1 0.8 13.35 0.59 8.92e-33 Menopause (age at onset); CRC cis rs6964587 0.692 rs418 chr7:91583334 C/T cg17063962 chr7:91808500 NA -0.62 -9.94 -0.48 1.59e-20 Breast cancer; CRC cis rs908922 0.676 rs11205033 chr1:152527966 C/A cg09873164 chr1:152488093 CRCT1 0.4 6.73 0.35 7.52e-11 Hair morphology; CRC cis rs1008375 0.898 rs9998130 chr4:17593905 A/G cg16339924 chr4:17578868 LAP3 0.69 8.87 0.44 4.59e-17 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs2115630 0.967 rs12595786 chr15:85336670 T/C cg12501888 chr15:85177176 SCAND2 -0.35 -5.8 -0.3 1.57e-8 P wave terminal force; CRC cis rs72945132 0.660 rs7121703 chr11:70140296 C/T cg00319359 chr11:70116639 PPFIA1 0.68 7.51 0.38 5.61e-13 Coronary artery disease; CRC cis rs4332037 0.575 rs55952733 chr7:2070680 G/A cg25834613 chr7:1915315 MAD1L1 -0.41 -5.82 -0.31 1.38e-8 Bipolar disorder; CRC cis rs9463078 0.605 rs3799984 chr6:44893640 C/G cg25276700 chr6:44698697 NA 0.24 5.88 0.31 1.03e-8 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; CRC cis rs34779708 0.931 rs4934704 chr10:35332164 C/T cg03585969 chr10:35415529 CREM 0.57 7.65 0.39 2.26e-13 Inflammatory bowel disease;Crohn's disease; CRC trans rs2303319 0.504 rs62188960 chr2:162492578 A/C cg07195197 chr16:1662150 IFT140 -0.7 -5.98 -0.31 5.91e-9 Cognitive function; CRC trans rs1814175 0.754 rs10219245 chr11:49645052 C/T cg15704280 chr7:45808275 SEPT13 -0.98 -19.1 -0.73 2.9e-55 Height; CRC cis rs2153535 0.580 rs5001324 chr6:8451604 A/T cg21535247 chr6:8435926 SLC35B3 0.5 7.45 0.38 8.15e-13 Motion sickness; CRC cis rs449789 0.857 rs4708817 chr6:159720640 A/G cg14500486 chr6:159655392 FNDC1 -0.48 -7.42 -0.38 1.03e-12 Pulse pressure; CRC cis rs9462027 0.606 rs2744941 chr6:34646917 A/G cg07306190 chr6:34760872 UHRF1BP1 -0.35 -6.32 -0.33 8.5e-10 Systemic lupus erythematosus; CRC cis rs6693567 0.565 rs834225 chr1:150300727 T/C cg04165759 chr1:150448943 RPRD2 0.34 5.62 0.3 4.11e-8 Migraine; CRC cis rs57994353 0.759 rs35873563 chr9:139324029 C/T cg13611204 chr9:139324423 INPP5E -0.45 -6.3 -0.33 9.48e-10 Eosinophil counts;Cutaneous squamous cell carcinoma; CRC cis rs2882667 0.929 rs34846849 chr5:138360578 T/C cg09476006 chr5:138032270 NA 0.48 7.59 0.39 3.22e-13 Age-related hearing impairment (SNP x SNP interaction); CRC trans rs9467711 0.720 rs9348716 chr6:26375658 G/A cg06606381 chr12:133084897 FBRSL1 -0.75 -5.99 -0.31 5.61e-9 Autism spectrum disorder or schizophrenia; CRC cis rs9969804 0.875 rs10992395 chr9:95433844 T/C cg14631576 chr9:95140430 CENPP -0.31 -5.73 -0.3 2.3e-8 Height; CRC trans rs7301826 0.627 rs7315707 chr12:131272819 A/G cg19959974 chr12:75905392 KRR1 0.49 6.25 0.33 1.28e-9 Plasma plasminogen activator levels; CRC cis rs75422866 0.867 rs73104152 chr12:48092874 A/C cg14736327 chr12:48174669 SLC48A1 -0.79 -6.01 -0.31 4.92e-9 Pneumonia; CRC cis rs853679 0.517 rs4713141 chr6:28101678 G/C cg12172441 chr6:28176163 NA 0.62 7.4 0.38 1.17e-12 Depression; CRC cis rs2204008 0.555 rs7310307 chr12:38107497 G/T cg13010199 chr12:38710504 ALG10B 0.46 5.64 0.3 3.66e-8 Bladder cancer; CRC cis rs367943 1.000 rs348955 chr5:112821643 C/T cg12552261 chr5:112820674 MCC -0.49 -7.67 -0.39 1.9e-13 Type 2 diabetes; CRC cis rs2235649 0.746 rs113666107 chr16:1848642 C/A cg00935504 chr16:1863053 HAGH 0.31 5.65 0.3 3.39e-8 Blood metabolite levels; CRC cis rs7769051 1.000 rs3813347 chr6:133119778 G/A cg22852734 chr6:133119734 C6orf192 1.06 12.98 0.58 2.17e-31 Type 2 diabetes nephropathy; CRC cis rs853679 0.517 rs9380055 chr6:28081629 A/G cg03623178 chr6:28175578 NA 0.95 12.17 0.56 2.13e-28 Depression; CRC cis rs11122272 0.667 rs2244992 chr1:231537220 T/C cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.57 -8.6 -0.43 3.21e-16 Hemoglobin concentration; CRC cis rs9814567 0.752 rs1880378 chr3:134330709 T/C cg06109529 chr3:134205091 CEP63;ANAPC13 -0.67 -9.58 -0.47 2.53e-19 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs7904368 0.806 rs1130684 chr10:16859335 C/G cg14835575 chr10:16859367 RSU1 0.53 7.33 0.37 1.82e-12 Ratio of the peak velocity of the mitral E-Wave divided by the peak velocity of the mitral A-wave.; CRC cis rs17445774 1.000 rs17445774 chr2:200859249 A/G cg23649088 chr2:200775458 C2orf69 -0.52 -7.23 -0.37 3.43e-12 LDL cholesterol to HDL cholesterol ratio; CRC cis rs9733 0.596 rs2065900 chr1:150652202 A/G cg10589385 chr1:150898437 SETDB1 0.28 5.98 0.31 5.86e-9 Tonsillectomy; CRC cis rs6951245 1.000 rs2363286 chr7:1091625 A/G cg03188948 chr7:1209495 NA 0.62 6.67 0.35 1.06e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs9660180 0.967 rs6603803 chr1:1812688 A/G cg17747265 chr1:1875780 NA -0.76 -13.38 -0.59 6.95e-33 Body mass index; CRC cis rs8180040 1.000 rs807936 chr3:47322496 C/T cg27129171 chr3:47204927 SETD2 0.57 8.88 0.44 4.4e-17 Colorectal cancer; CRC cis rs274567 0.501 rs581968 chr5:131710202 G/A cg02033258 chr5:131593261 PDLIM4 -0.38 -6.39 -0.33 5.55e-10 Blood metabolite levels; CRC cis rs9828933 0.752 rs13434089 chr3:63948566 C/T cg16258503 chr3:63850278 ATXN7;THOC7 0.76 7.99 0.4 2.31e-14 Type 2 diabetes; CRC cis rs2530545 0.512 rs10265324 chr7:34611746 C/T cg14401837 chr7:34697493 NPSR1 0.37 5.75 0.3 2.04e-8 IgG glycosylation; CRC cis rs7412746 0.658 rs72704682 chr1:150897677 A/T cg15448220 chr1:150897856 SETDB1 0.56 8.23 0.41 4.4e-15 Melanoma; CRC cis rs2204008 0.837 rs11514225 chr12:38076270 G/A cg13010199 chr12:38710504 ALG10B 0.45 5.64 0.3 3.67e-8 Bladder cancer; CRC cis rs7666738 0.830 rs9998682 chr4:98939009 T/C cg17366294 chr4:99064904 C4orf37 0.43 7.32 0.37 1.95e-12 Colonoscopy-negative controls vs population controls; CRC cis rs78456975 1.000 rs10189336 chr2:1558015 G/A cg26248373 chr2:1572462 NA -0.65 -7.02 -0.36 1.24e-11 Placebo response in major depressive disorder (% change in symptom score); CRC cis rs4728302 0.869 rs7792905 chr7:133595602 G/T cg10665199 chr7:133106180 EXOC4 0.38 5.79 0.3 1.66e-8 Intelligence;Intelligence (multi-trait analysis); CRC cis rs7917772 0.503 rs11191347 chr10:104351617 C/T cg04362960 chr10:104952993 NT5C2 -0.42 -5.77 -0.3 1.8e-8 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC trans rs11874712 0.965 rs11661945 chr18:43672194 T/A cg05477517 chr6:164531576 NA 0.41 6.1 0.32 2.9e-9 Migraine - clinic-based; CRC cis rs611744 0.647 rs631775 chr8:109252746 T/C cg18478394 chr8:109455254 TTC35 0.37 5.65 0.3 3.42e-8 Dupuytren's disease; CRC cis rs10463316 0.817 rs7708940 chr5:150789051 A/G cg03212797 chr5:150827313 SLC36A1 -0.44 -6.74 -0.35 7.27e-11 Metabolite levels (Pyroglutamine); CRC cis rs875971 1.000 rs1167612 chr7:65567976 C/A cg11764359 chr7:65958608 NA -0.6 -9.73 -0.47 7.88e-20 Aortic root size; CRC cis rs9402673 0.558 rs9688342 chr6:135323026 A/T cg24558204 chr6:135376177 HBS1L 0.51 8.13 0.41 9e-15 Reticulocyte count;High light scatter reticulocyte count; CRC cis rs10504229 0.906 rs73607868 chr8:58172482 T/C cg22535103 chr8:58192502 C8orf71 -0.82 -12.27 -0.56 9.63e-29 Developmental language disorder (linguistic errors); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg20739912 chr4:3294241 NA 0.43 6.52 0.34 2.6200000000000003e-10 Liver disease severity in Alagille syndrome; CRC cis rs4731207 0.596 rs1026839 chr7:124672599 C/T cg23710748 chr7:124431027 NA 0.37 5.85 0.31 1.19e-8 Cutaneous malignant melanoma; CRC cis rs6662572 0.671 rs12047120 chr1:46478496 A/G cg03123370 chr1:45965343 CCDC163P;MMACHC -0.46 -5.96 -0.31 6.45e-9 Blood protein levels; CRC cis rs77861329 1.000 rs893056 chr3:52109564 G/A cg08692210 chr3:52188851 WDR51A 0.85 7.76 0.39 1.08e-13 Macrophage inflammatory protein 1b levels; CRC cis rs2576037 0.583 rs12386118 chr18:44540376 C/G cg19077165 chr18:44547161 KATNAL2 -0.66 -10.92 -0.52 6.98e-24 Personality dimensions; CRC trans rs10504229 1.000 rs115548028 chr8:58170672 T/C cg04077850 chr5:125800366 GRAMD3 0.37 6.27 0.33 1.15e-9 Developmental language disorder (linguistic errors); CRC trans rs1728785 1.000 rs4783657 chr16:68586322 G/T cg04657470 chr2:198365150 HSPE1;HSPD1 0.59 7.14 0.37 6.21e-12 Ulcerative colitis; CRC cis rs9926296 0.533 rs10852623 chr16:89865242 T/C cg27121462 chr16:89883253 FANCA 0.59 9.7 0.47 1.02e-19 Vitiligo; CRC cis rs875971 0.825 rs28480509 chr7:66099224 A/G cg12463550 chr7:65579703 CRCP -0.46 -6.12 -0.32 2.73e-9 Aortic root size; CRC cis rs832540 0.898 rs2662024 chr5:56257515 T/C cg20203395 chr5:56204925 C5orf35 0.4 5.77 0.3 1.87e-8 Coronary artery disease; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg23036426 chr1:10093530 UBE4B 0.46 6.74 0.35 7.31e-11 Response to antipsychotic treatment; CRC cis rs826838 0.967 rs1719858 chr12:39124505 C/T cg26384229 chr12:38710491 ALG10B -0.62 -9.34 -0.46 1.5e-18 Heart rate; CRC cis rs11971779 0.553 rs36002669 chr7:139113161 T/A cg07862535 chr7:139043722 LUC7L2 0.59 7.48 0.38 6.62e-13 Diisocyanate-induced asthma; CRC cis rs1023500 0.573 rs4822088 chr22:42470589 G/C cg11915388 chr22:42470451 FAM109B -0.43 -6.51 -0.34 2.85e-10 Schizophrenia; CRC trans rs9467711 1.000 rs34569761 chr6:26334306 A/G cg15845792 chr6:28175446 NA 0.68 6.59 0.34 1.7e-10 Autism spectrum disorder or schizophrenia; CRC cis rs7584330 0.740 rs13426236 chr2:238447940 A/G cg16989719 chr2:238392110 NA -0.38 -6.98 -0.36 1.59e-11 Prostate cancer; CRC cis rs798554 0.796 rs2158694 chr7:2863443 T/G cg19346786 chr7:2764209 NA -0.41 -7.03 -0.36 1.23e-11 Height; CRC cis rs10771431 0.597 rs3759274 chr12:9353875 T/C cg08997352 chr12:9597637 DDX12 -0.45 -6.69 -0.35 9.48e-11 Breast size; CRC cis rs1862618 0.853 rs252919 chr5:56124111 T/C cg20203395 chr5:56204925 C5orf35 -0.69 -8.36 -0.42 1.79e-15 Initial pursuit acceleration; CRC cis rs6952809 0.532 rs6956223 chr7:2431331 T/C cg23289794 chr7:2394357 EIF3B -0.79 -9.67 -0.47 1.22e-19 Multiple sclerosis; CRC cis rs2243480 1.000 rs1499614 chr7:65730798 A/T cg18252515 chr7:66147081 NA -1.22 -14.06 -0.61 1.66e-35 Diabetic kidney disease; CRC cis rs2204008 0.837 rs2892296 chr12:37969785 C/T cg13010199 chr12:38710504 ALG10B -0.48 -7.17 -0.37 5.01e-12 Bladder cancer; CRC cis rs1348850 0.793 rs13027299 chr2:178455501 T/G cg02961200 chr2:178257176 LOC100130691;AGPS 0.48 6.68 0.35 1.05e-10 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs10089 0.552 rs59430737 chr5:127557568 C/T cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.64 7.65 0.39 2.31e-13 Ileal carcinoids; CRC cis rs2204008 0.599 rs2320526 chr12:38220405 T/A cg26384229 chr12:38710491 ALG10B 0.64 8.86 0.44 5.07e-17 Bladder cancer; CRC cis rs4132509 1.000 rs2290754 chr1:243806268 A/C cg21452805 chr1:244014465 NA 0.5 6.9 0.36 2.66e-11 RR interval (heart rate); CRC cis rs910316 1.000 rs175436 chr14:75608683 C/G cg11812906 chr14:75593930 NEK9 -0.63 -9.98 -0.48 1.12e-20 Height; CRC cis rs208520 0.690 rs4618506 chr6:66756889 A/C cg07460842 chr6:66804631 NA -0.98 -13.66 -0.6 5.72e-34 Exhaled nitric oxide output; CRC trans rs6703335 0.870 rs10803142 chr1:243598234 A/G cg01490821 chr2:170684022 UBR3 0.44 6.09 0.32 3.19e-9 Schizophrenia;Schizophrenia, schizoaffective disorder or bipolar disorder; CRC cis rs2013441 1.000 rs9905493 chr17:20188581 C/G cg13482628 chr17:19912719 NA -0.41 -6.28 -0.33 1.07e-9 Obesity-related traits; CRC cis rs4665809 0.590 rs66477033 chr2:26472497 T/C cg22920501 chr2:26401640 FAM59B 0.85 12.21 0.56 1.54e-28 Gut microbiome composition (summer); CRC cis rs2816062 0.721 rs2816047 chr1:18893728 A/C cg18795169 chr1:18902165 NA -0.92 -19.27 -0.73 6.24e-56 Urate levels in lean individuals; CRC trans rs2303319 0.504 rs35304298 chr2:162617185 G/T cg13490827 chr1:46269305 MAST2 -0.68 -5.99 -0.31 5.44e-9 Cognitive function; CRC cis rs17253792 0.545 rs35294669 chr14:56017438 T/A cg01858014 chr14:56050164 KTN1 -0.86 -6.64 -0.34 1.27e-10 Putamen volume; CRC cis rs6502050 0.835 rs7503111 chr17:80101587 A/T cg11859384 chr17:80120422 CCDC57 -0.37 -5.85 -0.31 1.16e-8 Life satisfaction; CRC cis rs910316 1.000 rs11845639 chr14:75570293 C/T cg08847533 chr14:75593920 NEK9 0.91 17.12 0.69 2e-47 Height; CRC cis rs12042938 0.600 rs823161 chr1:231775017 G/A cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX 0.5 6.94 0.36 2.05e-11 Neuranatomic and neurocognitive phenotypes; CRC cis rs8032158 0.702 rs1042477 chr15:56121886 C/A cg02198044 chr15:56286336 NEDD4 -0.36 -5.73 -0.3 2.33e-8 Keloid; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg22541143 chr4:84377292 HELQ;MRPS18C 0.39 6.27 0.33 1.16e-9 Liver disease severity in Alagille syndrome; CRC cis rs9788333 0.695 rs12871086 chr13:21890224 A/T cg21970626 chr13:21893289 NA -0.44 -8.42 -0.42 1.16e-15 Thiazide-induced adverse metabolic effects in hypertensive patients; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg24341800 chr11:107992076 ACAT1 0.49 6.31 0.33 8.81e-10 Thyroid stimulating hormone; CRC cis rs2274471 0.634 rs913594 chr9:5063199 C/T cg03390472 chr9:5043263 JAK2 -0.55 -6.82 -0.35 4.42e-11 Crohn's disease; CRC cis rs6089584 0.962 rs6142913 chr20:60566950 A/G cg18761221 chr20:60518478 NA 0.44 7.46 0.38 7.77e-13 Body mass index; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg16245844 chr12:1800488 ADIPOR2 0.33 6.2 0.32 1.7e-9 Liver disease severity in Alagille syndrome; CRC cis rs6540559 0.611 rs17015226 chr1:209970096 C/G cg25204440 chr1:209979598 IRF6 0.47 5.71 0.3 2.49e-8 Cleft lip with or without cleft palate; CRC cis rs35883536 0.647 rs2647325 chr1:101040195 T/C cg06223162 chr1:101003688 GPR88 0.34 6.31 0.33 8.82e-10 Monocyte count; CRC cis rs35110281 0.811 rs2838337 chr21:45072621 A/C cg04455712 chr21:45112962 RRP1B 0.42 8.09 0.41 1.15e-14 Mean corpuscular volume; CRC cis rs12824058 0.678 rs11614163 chr12:130814621 C/G cg24838063 chr12:130822603 PIWIL1 0.57 9.31 0.46 1.83e-18 Menopause (age at onset); CRC cis rs6952808 0.689 rs58227534 chr7:2046328 A/G cg22963979 chr7:1858916 MAD1L1 -0.52 -7.62 -0.39 2.82e-13 Bipolar disorder and schizophrenia; CRC cis rs28386778 0.897 rs1877318 chr17:61819960 G/A cg06601766 chr17:61851465 DDX42;CCDC47 0.44 5.97 0.31 6.13e-9 Prudent dietary pattern; CRC cis rs2836974 0.897 rs68090597 chr21:40535633 A/G cg06238570 chr21:40685208 BRWD1 0.7 10.07 0.49 5.84e-21 Cognitive function; CRC cis rs4862750 0.872 rs1991254 chr4:187875375 T/G cg07414643 chr4:187882934 NA 0.39 6.59 0.34 1.71e-10 Lobe attachment (rater-scored or self-reported); CRC cis rs35520189 0.591 rs12464758 chr2:113703281 T/C cg12858261 chr2:113808755 IL1F8 0.49 6.87 0.35 3.29e-11 Obstructive sleep apnea trait (apnea hypopnea index); CRC cis rs10191773 0.589 rs72831636 chr2:112948248 G/A cg24977338 chr2:113188963 RGPD8;RGPD5 -0.66 -5.75 -0.3 2.07e-8 Yeast infection; CRC cis rs951366 0.789 rs1772148 chr1:205704580 A/T cg23034840 chr1:205782522 SLC41A1 0.47 6.43 0.33 4.37e-10 Menarche (age at onset); CRC cis rs780096 0.587 rs6743819 chr2:27567407 G/T cg27432699 chr2:27873401 GPN1 -0.48 -7.35 -0.38 1.61e-12 Total body bone mineral density; CRC cis rs1799949 0.965 rs9646413 chr17:41426157 A/G cg19454999 chr17:41278357 BRCA1;NBR2 0.38 5.72 0.3 2.37e-8 Menopause (age at onset); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg01497487 chr22:38141814 TRIOBP 0.43 6.34 0.33 7.48e-10 Intelligence (multi-trait analysis); CRC cis rs10089 1.000 rs17764954 chr5:127514436 A/T cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.67 8.63 0.43 2.6e-16 Ileal carcinoids; CRC cis rs1707322 1.000 rs7538978 chr1:46505054 C/T cg03146154 chr1:46216737 IPP -0.49 -6.83 -0.35 4.07e-11 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs9311474 0.508 rs11720159 chr3:52617802 T/G cg18404041 chr3:52824283 ITIH1 -0.4 -8.37 -0.42 1.66e-15 Electroencephalogram traits; CRC cis rs6540559 0.673 rs6698154 chr1:210007777 A/G cg21951975 chr1:209979733 IRF6 0.46 5.6 0.3 4.48e-8 Cleft lip with or without cleft palate; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg05397609 chr1:67896184 SERBP1 0.44 6.36 0.33 6.92e-10 Intelligence (multi-trait analysis); CRC cis rs7089973 0.932 rs17794346 chr10:116643095 C/T cg23260525 chr10:116636907 FAM160B1 -0.32 -6.05 -0.32 3.86e-9 Bipolar disorder or attention deficit hyperactivity disorder; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg23155395 chr7:128045684 IMPDH1 0.38 6.45 0.34 4.02e-10 Liver disease severity in Alagille syndrome; CRC trans rs1814175 0.616 rs847641 chr11:49919261 T/C cg11707556 chr5:10655725 ANKRD33B -0.52 -9.91 -0.48 1.94e-20 Height; CRC cis rs28386778 1.000 rs2665851 chr17:61957023 T/C cg06873352 chr17:61820015 STRADA 0.75 14.1 0.61 1.17e-35 Prudent dietary pattern; CRC cis rs7666738 0.716 rs7656233 chr4:99079237 G/A cg17366294 chr4:99064904 C4orf37 0.35 5.77 0.3 1.82e-8 Colonoscopy-negative controls vs population controls; CRC cis rs4819052 0.851 rs8131143 chr21:46671646 C/G cg02159808 chr21:46707872 POFUT2;LOC642852 -0.5 -6.55 -0.34 2.16e-10 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs7811142 1.000 rs11769700 chr7:100090049 T/C cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.74 9.96 0.48 1.4e-20 Platelet count; CRC cis rs7412746 0.586 rs2864882 chr1:150883037 C/T cg10589385 chr1:150898437 SETDB1 0.28 6.07 0.32 3.43e-9 Melanoma; CRC cis rs2976388 0.609 rs2717605 chr8:143801015 T/G cg12516270 chr8:143859308 LYNX1 0.4 7.08 0.36 9.03e-12 Urinary tract infection frequency; CRC cis rs78456975 0.527 rs11885279 chr2:1560633 T/C cg26248373 chr2:1572462 NA -0.8 -10.96 -0.52 4.81e-24 Placebo response in major depressive disorder (% change in symptom score); CRC cis rs208520 1.000 rs28773210 chr6:66993566 C/T cg07460842 chr6:66804631 NA 0.92 11.19 0.53 7.51e-25 Exhaled nitric oxide output; CRC cis rs933688 0.938 rs6869048 chr5:90664322 G/C cg26981201 chr5:90679533 LOC100129716;ARRDC3 1.02 17.89 0.7 1.85e-50 Smoking behavior; CRC cis rs1448094 0.512 rs7137596 chr12:86239884 C/G cg19622623 chr12:86230825 RASSF9 -0.41 -6.73 -0.35 7.69e-11 Major depressive disorder; CRC cis rs3026445 0.672 rs10774603 chr12:111155947 C/T cg12870014 chr12:110450643 ANKRD13A 0.39 5.93 0.31 7.76e-9 QT interval; CRC cis rs1799949 1.000 rs12950607 chr17:41299928 G/C cg23758822 chr17:41437982 NA 0.79 13.45 0.6 3.6e-33 Menopause (age at onset); CRC cis rs6540556 0.723 rs12090931 chr1:209889601 A/G cg05527609 chr1:210001259 C1orf107 -0.56 -5.88 -0.31 1.01e-8 Red blood cell count; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg25955816 chr1:228612876 HIST3H3 -0.38 -5.98 -0.31 5.81e-9 Liver disease severity in Alagille syndrome; CRC cis rs10504229 0.683 rs11786523 chr8:58131319 G/C cg24829409 chr8:58192753 C8orf71 -0.55 -8.03 -0.4 1.71e-14 Developmental language disorder (linguistic errors); CRC cis rs4713118 0.588 rs200994 chr6:27813813 A/C cg08798685 chr6:27730294 NA 0.46 6.22 0.32 1.55e-9 Parkinson's disease; CRC cis rs9372498 0.536 rs62422228 chr6:118957276 T/C cg15382696 chr6:118971807 C6orf204 0.6 7.53 0.38 5.03e-13 Diastolic blood pressure; CRC cis rs2404602 0.647 rs11072610 chr15:76930805 C/A cg03037974 chr15:76606532 NA -0.51 -7.2 -0.37 4.17e-12 Blood metabolite levels; CRC cis rs1707322 0.721 rs4609469 chr1:46117185 C/T cg03146154 chr1:46216737 IPP 0.67 9.74 0.47 7.45e-20 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC trans rs916888 0.821 rs70600 chr17:44860021 C/T cg01341218 chr17:43662625 NA 0.88 9.66 0.47 1.31e-19 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg09820084 chr6:18387507 RNF144B -0.52 -6.37 -0.33 6.26e-10 Diisocyanate-induced asthma; CRC trans rs9951602 0.541 rs56882694 chr18:76647010 C/T cg02800362 chr5:177631904 HNRNPAB 0.69 9.88 0.48 2.49e-20 Obesity-related traits; CRC cis rs11677416 1.000 rs1516789 chr2:113531024 C/T cg27083787 chr2:113543245 IL1A 0.47 6.74 0.35 6.99e-11 Response to antipsychotic treatment in schizophrenia (working memory); CRC cis rs2836974 0.545 rs8128901 chr21:40710419 G/A cg11890956 chr21:40555474 PSMG1 0.68 9.91 0.48 2.04e-20 Cognitive function; CRC cis rs10256972 0.706 rs4285396 chr7:1123738 A/G cg16145915 chr7:1198662 ZFAND2A -0.41 -7.93 -0.4 3.51e-14 Longevity;Endometriosis; CRC cis rs7044106 0.791 rs10984995 chr9:123479210 C/T cg09419670 chr9:123605666 PSMD5;LOC253039 0.72 11.71 0.54 1.02e-26 Hip circumference adjusted for BMI; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg25146111 chr4:40059615 N4BP2;LOC344967 0.45 6.23 0.32 1.43e-9 Response to antipsychotic treatment; CRC cis rs898097 0.625 rs898095 chr17:80890638 T/C cg03160526 chr17:80928410 B3GNTL1 0.49 8.01 0.4 1.99e-14 Breast cancer; CRC cis rs561341 1.000 rs521919 chr17:30298039 G/T cg12193833 chr17:30244370 NA -0.63 -8.19 -0.41 5.67e-15 Hip circumference adjusted for BMI; CRC cis rs6860806 0.507 rs272872 chr5:131675864 C/T cg18758796 chr5:131593413 PDLIM4 -0.37 -6.1 -0.32 2.92e-9 Breast cancer; CRC cis rs6952808 0.862 rs4721135 chr7:1912222 A/G cg21782813 chr7:2030301 MAD1L1 0.38 6.76 0.35 6.19e-11 Bipolar disorder and schizophrenia; CRC cis rs561341 0.882 rs28649357 chr17:30367190 A/G cg23018236 chr17:30244563 NA -0.49 -6.4 -0.33 5.22e-10 Hip circumference adjusted for BMI; CRC cis rs2836974 0.666 rs4624474 chr21:40686327 T/C cg11644478 chr21:40555479 PSMG1 -0.63 -9.69 -0.47 1.11e-19 Cognitive function; CRC cis rs561341 0.714 rs473535 chr17:30312365 A/G cg12193833 chr17:30244370 NA -0.75 -8.74 -0.43 1.23e-16 Hip circumference adjusted for BMI; CRC cis rs5769765 0.862 rs56377703 chr22:50306940 C/T cg22709217 chr22:50311962 ALG12;CRELD2 -1.08 -17.68 -0.7 1.22e-49 Schizophrenia; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg19219560 chr2:88926950 EIF2AK3 0.5 6.96 0.36 1.83e-11 Response to antipsychotic treatment; CRC cis rs3736485 0.808 rs28813458 chr15:51947023 A/G cg08986416 chr15:51914746 DMXL2 -0.44 -6.24 -0.33 1.36e-9 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs951366 0.789 rs823130 chr1:205714372 C/T cg14159672 chr1:205819179 PM20D1 0.73 10.56 0.5 1.23e-22 Menarche (age at onset); CRC cis rs11625487 0.609 rs74063377 chr14:77951431 C/G cg20045696 chr14:77926864 AHSA1 -0.71 -6.78 -0.35 5.51e-11 Neutrophil percentage of white cells;Sum neutrophil eosinophil counts;Neutrophil count; CRC cis rs4731207 0.698 rs6966415 chr7:124531469 G/A cg23710748 chr7:124431027 NA -0.38 -6.06 -0.32 3.65e-9 Cutaneous malignant melanoma; CRC cis rs7552404 0.765 rs211717 chr1:76106969 G/A cg22875332 chr1:76189707 ACADM -0.67 -9.0 -0.44 1.87e-17 Blood metabolite levels;Acylcarnitine levels; CRC cis rs225245 0.755 rs6505491 chr17:34026335 A/G cg05299278 chr17:33885742 SLFN14 0.5 8.12 0.41 9.57e-15 Reticulocyte count;Reticulocyte fraction of red cells;High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells; CRC cis rs2814982 0.605 rs80254589 chr6:34478514 C/T cg14254433 chr6:34482411 PACSIN1 -0.84 -8.54 -0.43 5.1e-16 Cholesterol, total;Total cholesterol levels; CRC trans rs6956675 1.000 rs10280052 chr7:62600311 C/T cg01314568 chr7:57830625 NA -0.69 -9.4 -0.46 9.55e-19 Obesity-related traits; CRC cis rs17345786 1.000 rs17345786 chr3:101318318 A/C cg11279151 chr3:101281821 RG9MTD1 0.71 8.98 0.44 2.2e-17 Colonoscopy-negative controls vs population controls; CRC cis rs875971 0.545 rs316323 chr7:65610989 C/T cg11764359 chr7:65958608 NA -0.47 -6.01 -0.31 4.95e-9 Aortic root size; CRC cis rs995000 0.895 rs1472257 chr1:63042126 A/G cg19896129 chr1:63156450 NA -0.43 -6.7 -0.35 8.85e-11 Triglyceride levels; CRC cis rs736408 0.505 rs2083180 chr3:52668119 G/T cg18404041 chr3:52824283 ITIH1 -0.41 -8.66 -0.43 2.23e-16 Bipolar disorder; CRC cis rs12134245 0.776 rs12124682 chr1:91995542 A/G cg25838465 chr1:92012736 NA -0.68 -12.57 -0.57 7.32e-30 Breast cancer; CRC cis rs79839061 0.518 rs11734537 chr4:869174 A/G cg14530993 chr4:882597 GAK 0.82 7.83 0.4 6.7e-14 Intelligence (multi-trait analysis); CRC cis rs875971 0.862 rs1083554 chr7:65852341 T/C cg12463550 chr7:65579703 CRCP 0.48 6.52 0.34 2.72e-10 Aortic root size; CRC cis rs6429082 0.518 rs1812350 chr1:235659920 C/A cg26050004 chr1:235667680 B3GALNT2 0.78 13.37 0.59 7.09e-33 Adiposity; CRC cis rs947211 0.950 rs885224 chr1:205753097 A/G cg26354017 chr1:205819088 PM20D1 0.43 5.98 0.31 5.93e-9 Parkinson's disease; CRC cis rs17023223 0.537 rs12064033 chr1:119709558 G/A cg05756136 chr1:119680316 WARS2 -0.52 -7.14 -0.37 6e-12 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for BMI in active individuals; CRC cis rs35146811 0.735 rs11764176 chr7:99786964 G/T cg00553149 chr7:99775558 STAG3;GPC2 0.24 5.9 0.31 8.81e-9 Coronary artery disease; CRC cis rs554111 0.891 rs531044 chr1:21057011 T/C cg08890418 chr1:21044141 KIF17 0.32 6.05 0.32 3.88e-9 Facial morphology (factor 17, height of vermillion upper lip); CRC cis rs875971 0.502 rs2465121 chr7:65621004 A/G cg03233332 chr7:66118400 NA 0.43 5.78 0.3 1.71e-8 Aortic root size; CRC cis rs12190007 0.573 rs3006218 chr6:169868769 G/A cg15038512 chr6:170123185 PHF10 -0.37 -5.76 -0.3 1.9e-8 Obesity-related traits; CRC cis rs10979 0.571 rs7764231 chr6:143919151 C/G cg25407410 chr6:143891975 LOC285740 -0.6 -7.48 -0.38 6.93e-13 Hypospadias; CRC cis rs4332037 0.539 rs1533827 chr7:2074290 A/G cg02421172 chr7:1938701 MAD1L1 -0.42 -5.82 -0.31 1.38e-8 Bipolar disorder; CRC cis rs929354 0.553 rs34498858 chr7:156931337 T/C cg16102536 chr7:156981717 UBE3C 0.4 6.73 0.35 7.36e-11 Body mass index; CRC cis rs4665809 0.525 rs10865402 chr2:26535383 A/G cg04944784 chr2:26401820 FAM59B -0.48 -5.96 -0.31 6.65e-9 Gut microbiome composition (summer); CRC cis rs10540 0.730 rs34690033 chr11:492677 G/C cg19913688 chr11:428466 ANO9 -0.69 -7.15 -0.37 5.67e-12 Body mass index; CRC cis rs1552244 1.000 rs6772315 chr3:10113644 G/A cg00166722 chr3:10149974 C3orf24 0.7 9.4 0.46 9.47e-19 Alzheimer's disease; CRC cis rs11098499 0.863 rs1552095 chr4:120460306 A/G cg09307838 chr4:120376055 NA 0.7 10.28 0.49 1.1e-21 Corneal astigmatism; CRC cis rs9296404 1 rs9296404 chr6:42925803 T/C cg02353165 chr6:42928485 GNMT 0.72 12.11 0.56 3.75e-28 Plasma homocysteine levels (post-methionine load test); CRC cis rs10752881 1.000 rs10911185 chr1:182971747 G/C ch.1.3577855R chr1:183094577 LAMC1 0.87 15.2 0.64 6.75e-40 Colorectal cancer; CRC cis rs9309711 0.506 rs9284794 chr2:3492052 G/A cg15541040 chr2:3486749 NA -0.51 -7.93 -0.4 3.55e-14 Neurofibrillary tangles; CRC cis rs11190604 1.000 rs7084810 chr10:102297546 A/G cg07080220 chr10:102295463 HIF1AN 0.47 5.66 0.3 3.31e-8 Palmitoleic acid (16:1n-7) levels; CRC cis rs9902453 0.967 rs61014003 chr17:28485233 A/G cg26525008 chr17:28256777 EFCAB5;SSH2 0.55 8.3 0.42 2.78e-15 Coffee consumption (cups per day); CRC cis rs3889199 0.887 rs7522429 chr1:59661437 G/T cg25881383 chr1:59680599 NA -0.39 -6.23 -0.32 1.41e-9 Pulse pressure; CRC cis rs7811142 0.830 rs11769057 chr7:99964661 A/G cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.11 15.96 0.66 7.52e-43 Platelet count; CRC cis rs72634258 0.838 rs10489450 chr1:8079301 C/T cg00042356 chr1:8021962 PARK7 0.67 7.42 0.38 9.91e-13 Inflammatory bowel disease; CRC cis rs853679 0.517 rs9348796 chr6:28126202 A/G cg23161317 chr6:28129485 ZNF389 0.53 6.43 0.33 4.52e-10 Depression; CRC cis rs12451471 0.637 rs12452616 chr17:78090081 A/G cg20811857 chr17:78079795 GAA 0.45 6.69 0.35 9.42e-11 Plateletcrit;Mean corpuscular hemoglobin concentration; CRC cis rs1552244 1.000 rs7631678 chr3:10078816 T/G cg13047869 chr3:10149882 C3orf24 0.57 7.76 0.39 1.1e-13 Alzheimer's disease; CRC cis rs4722166 0.704 rs4321884 chr7:22741459 A/T cg26061582 chr7:22766209 IL6 0.38 5.83 0.31 1.35e-8 Lung cancer; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg11614195 chr16:2265446 PGP 0.43 6.14 0.32 2.41e-9 Response to antipsychotic treatment; CRC cis rs77861329 1.000 rs352151 chr3:52210272 C/G cg08692210 chr3:52188851 WDR51A 0.84 7.86 0.4 5.6e-14 Macrophage inflammatory protein 1b levels; CRC cis rs2745967 0.765 rs2785647 chr1:208079715 G/A cg09788693 chr1:208063733 CD34 0.42 6.42 0.33 4.67e-10 Resting heart rate; CRC cis rs1941023 0.503 rs11230288 chr11:60128968 G/A cg08716584 chr11:60157161 MS4A7 -0.51 -8.51 -0.42 6.14e-16 Congenital heart disease (maternal effect); CRC cis rs13108904 0.870 rs2291199 chr4:1244267 A/G cg05665937 chr4:1216051 CTBP1 0.39 5.78 0.3 1.7e-8 Obesity-related traits; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg11608447 chr9:38620746 ANKRD18A;C9orf122 0.38 6.3 0.33 9.48e-10 Liver disease severity in Alagille syndrome; CRC cis rs6570726 0.905 rs421032 chr6:145827771 A/G cg05347473 chr6:146136440 FBXO30 0.36 5.7 0.3 2.73e-8 Lobe attachment (rater-scored or self-reported); CRC cis rs3617 0.573 rs3821873 chr3:52913006 C/T cg18099408 chr3:52552593 STAB1 0.33 5.67 0.3 3.2e-8 Red blood cell count;Autism spectrum disorder or schizophrenia; CRC cis rs875971 0.895 rs12698520 chr7:65918707 C/A cg11764359 chr7:65958608 NA 0.62 9.92 0.48 1.87e-20 Aortic root size; CRC cis rs896854 0.714 rs6471503 chr8:95990283 G/A cg23172400 chr8:95962367 TP53INP1 -0.47 -7.94 -0.4 3.28e-14 Type 2 diabetes; CRC cis rs10791323 0.582 rs2723613 chr11:133706696 G/A cg00579200 chr11:133705235 NA -0.4 -5.75 -0.3 2e-8 Childhood ear infection; CRC cis rs951366 0.789 rs823094 chr1:205689807 G/T cg14893161 chr1:205819251 PM20D1 -0.8 -13.35 -0.59 8.38e-33 Menarche (age at onset); CRC cis rs9549367 0.713 rs56002882 chr13:113830694 T/C cg18105134 chr13:113819100 PROZ -0.85 -12.36 -0.56 4.43e-29 Platelet distribution width; CRC cis rs9467773 0.595 rs3846845 chr6:26444915 G/A cg09904177 chr6:26538194 HMGN4 -0.45 -6.28 -0.33 1.07e-9 Intelligence (multi-trait analysis); CRC cis rs10479542 0.752 rs12658664 chr5:178986987 C/T cg26516362 chr5:178986906 RUFY1 0.37 6.61 0.34 1.56e-10 Lung cancer; CRC cis rs9326248 0.559 rs484646 chr11:116732856 A/G cg26566898 chr11:117069891 TAGLN 0.29 6.09 0.32 3.1e-9 Blood protein levels; CRC cis rs12887734 0.524 rs12588797 chr14:104300020 C/T cg01849466 chr14:104193079 ZFYVE21 0.44 6.9 0.36 2.61e-11 Schizophrenia;Autism spectrum disorder or schizophrenia; CRC cis rs4713118 0.587 rs61471148 chr6:28037032 T/A cg12273811 chr6:28175739 NA 0.63 8.07 0.41 1.35e-14 Parkinson's disease; CRC cis rs9398803 0.965 rs9388489 chr6:126698719 C/T cg19875578 chr6:126661172 C6orf173 -0.42 -5.71 -0.3 2.56e-8 Male-pattern baldness; CRC cis rs4718428 0.705 rs4718424 chr7:66376095 G/A cg18252515 chr7:66147081 NA -0.54 -7.63 -0.39 2.58e-13 Corneal structure; CRC cis rs17253792 0.822 rs77197405 chr14:56159662 T/A cg01858014 chr14:56050164 KTN1 -0.88 -7.08 -0.36 8.77e-12 Putamen volume; CRC cis rs7613875 0.620 rs7624030 chr3:50071279 A/C cg24110177 chr3:50126178 RBM5 0.53 7.93 0.4 3.51e-14 Body mass index; CRC cis rs7635838 0.892 rs9814907 chr3:11438645 G/A cg00170343 chr3:11313890 ATG7 0.41 6.28 0.33 1.08e-9 HDL cholesterol; CRC cis rs3812762 0.912 rs11042058 chr11:8763815 A/T cg21881798 chr11:8931708 C11orf17;ST5 -0.42 -6.02 -0.32 4.62e-9 Hypospadias; CRC cis rs2276314 0.947 rs3898595 chr18:33565885 T/A cg05985134 chr18:33552581 C18orf21 0.46 6.41 0.33 5.06e-10 Endometriosis;Drug-induced torsades de pointes; CRC cis rs6500395 1.000 rs9931737 chr16:48623539 C/T cg04672837 chr16:48644449 N4BP1 0.45 6.75 0.35 6.7e-11 Response to tocilizumab in rheumatoid arthritis; CRC cis rs28386778 0.799 rs2727322 chr17:61921706 G/A cg25654072 chr17:61904446 PSMC5;FTSJ3 0.7 10.94 0.52 5.62e-24 Prudent dietary pattern; CRC trans rs916888 0.821 rs70602 chr17:44859715 T/C cg23590916 chr17:43697445 MGC57346 -0.57 -6.14 -0.32 2.32e-9 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs2933343 0.700 rs876754 chr3:128627753 T/C cg11901034 chr3:128598214 ACAD9 -0.56 -8.11 -0.41 1.01e-14 IgG glycosylation; CRC cis rs679087 1.000 rs439639 chr12:29917641 A/C cg14258853 chr12:29935411 TMTC1 -0.45 -7.61 -0.39 2.87e-13 Schizophrenia; CRC cis rs10911363 0.615 rs12024309 chr1:183419981 A/G cg09173681 chr1:183549694 NCF2 -0.75 -10.31 -0.49 9.05e-22 Systemic lupus erythematosus; CRC cis rs3760982 0.813 rs8111664 chr19:44295092 G/A cg12072164 chr19:44306565 LYPD5 -0.45 -7.15 -0.37 5.71e-12 Breast cancer (estrogen-receptor negative);Breast cancer; CRC cis rs7412746 0.658 rs8444 chr1:150938571 G/A cg10589385 chr1:150898437 SETDB1 0.32 6.82 0.35 4.3e-11 Melanoma; CRC cis rs7216064 1.000 rs12451707 chr17:65871598 G/A cg12091567 chr17:66097778 LOC651250 -0.67 -7.74 -0.39 1.24e-13 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CRC cis rs6735179 0.565 rs733376 chr2:1751958 C/A cg19300414 chr2:1746591 PXDN 0.46 7.85 0.4 6.01e-14 Response to antipsychotic treatment; CRC cis rs7312933 0.510 rs10880223 chr12:42413443 G/A cg01256987 chr12:42539512 GXYLT1 -0.57 -9.96 -0.48 1.37e-20 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CRC cis rs6866344 0.570 rs56236920 chr5:178144617 C/T cg03877680 chr5:178157825 ZNF354A 0.79 11.38 0.53 1.57e-25 Neutrophil percentage of white cells; CRC cis rs780096 0.526 rs2010087 chr2:27637235 C/T cg17158414 chr2:27665306 KRTCAP3 -0.29 -6.23 -0.32 1.45e-9 Total body bone mineral density; CRC trans rs2303319 0.504 rs56009150 chr2:162598582 T/C cg14875682 chr5:52083620 ITGA1;PELO -0.76 -6.4 -0.33 5.35e-10 Cognitive function; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg00578828 chr5:131826934 IRF1 0.48 6.61 0.34 1.52e-10 Response to antipsychotic treatment; CRC trans rs11098499 0.954 rs1480931 chr4:120395809 G/T cg25214090 chr10:38739885 LOC399744 0.62 9.95 0.48 1.44e-20 Corneal astigmatism; CRC trans rs637571 0.726 rs689274 chr11:65665988 A/G cg17712092 chr4:129076599 LARP1B -0.74 -12.54 -0.57 9.67e-30 Eosinophil percentage of white cells; CRC cis rs9359856 0.636 rs9294440 chr6:90308666 C/G cg13799429 chr6:90582589 CASP8AP2 0.59 7.88 0.4 4.77e-14 Bipolar disorder; CRC cis rs8072100 1.000 rs8072100 chr17:45674687 A/T cg25173405 chr17:45401733 C17orf57 0.47 7.28 0.37 2.51e-12 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs172166 0.611 rs203883 chr6:28078356 A/G cg10876282 chr6:28092338 ZSCAN16 0.5 6.6 0.34 1.61e-10 Cardiac Troponin-T levels; CRC cis rs4285028 0.848 rs4118376 chr3:121636450 G/A cg11130432 chr3:121712080 ILDR1 -0.5 -6.18 -0.32 1.89e-9 Multiple sclerosis; CRC cis rs3087591 0.960 rs9807077 chr17:29634457 A/G cg24425628 chr17:29625626 OMG;NF1 -0.89 -16.85 -0.68 2.31e-46 Hip circumference; CRC cis rs3749237 0.595 rs35701831 chr3:49515000 A/C cg07636037 chr3:49044803 WDR6 0.54 7.79 0.39 9.09e-14 Resting heart rate; CRC cis rs9649213 0.593 rs6465675 chr7:97982103 C/T cg21770322 chr7:97807741 LMTK2 -0.53 -8.67 -0.43 2.07e-16 Prostate cancer (SNP x SNP interaction); CRC cis rs2019137 0.539 rs11123170 chr2:113978940 C/G cg19083407 chr2:113993142 PAX8;LOC440839;LOC654433 0.61 8.94 0.44 2.96e-17 Lymphocyte counts; CRC cis rs7937682 0.562 rs10891276 chr11:111370415 A/C cg19812747 chr11:111475976 SIK2 -0.46 -7.39 -0.38 1.25e-12 Primary sclerosing cholangitis; CRC cis rs1971762 0.523 rs3852562 chr12:54085750 T/C cg06632207 chr12:54070931 ATP5G2 0.39 6.71 0.35 8.61e-11 Height; CRC cis rs9372498 0.505 rs4416700 chr6:118975461 G/C cg15382696 chr6:118971807 C6orf204 0.59 7.18 0.37 4.64e-12 Diastolic blood pressure; CRC cis rs7572733 0.592 rs4389332 chr2:198477620 G/T cg10820045 chr2:198174542 NA 0.35 6.38 0.33 6.12e-10 Dermatomyositis; CRC cis rs58804349 0.581 rs12221397 chr10:43239833 A/G cg15903213 chr10:43522190 NA 0.72 5.77 0.3 1.85e-8 Pediatric bone mineral content (radius); CRC cis rs1552244 1.000 rs6791810 chr3:10124444 A/G cg16606324 chr3:10149918 C3orf24 -0.71 -9.72 -0.47 8.6e-20 Alzheimer's disease; CRC cis rs9814567 1.000 rs3846055 chr3:134203973 T/A cg06109529 chr3:134205091 CEP63;ANAPC13 -0.82 -12.51 -0.57 1.2e-29 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs5758511 0.773 rs12167978 chr22:42346475 G/A cg00645731 chr22:42541494 CYP2D7P1 0.47 7.02 0.36 1.3e-11 Birth weight; CRC cis rs9487051 0.676 rs6568566 chr6:109596792 G/A cg21918786 chr6:109611834 NA -0.41 -7.17 -0.37 4.84e-12 Reticulocyte fraction of red cells; CRC cis rs2842992 0.830 rs2495279 chr6:160138796 C/T cg19482086 chr6:160211437 TCP1;MRPL18 0.7 8.85 0.44 5.32e-17 Age-related macular degeneration (geographic atrophy); CRC cis rs12497850 0.797 rs61583136 chr3:49189195 C/T cg03060546 chr3:49711283 APEH 0.4 5.61 0.3 4.38e-8 Parkinson's disease; CRC cis rs2579519 0.547 rs11683523 chr2:96544855 T/C cg23100626 chr2:96804247 ASTL 0.27 7.1 0.36 7.79e-12 Diastolic blood pressure; CRC trans rs6550704 0.687 rs9865314 chr3:22634337 A/G cg25369027 chr8:103666178 KLF10 -0.43 -6.29 -0.33 1.03e-9 Daytime sleep phenotypes; CRC cis rs10450586 0.932 rs10450562 chr11:27310006 A/G cg10370305 chr11:27303972 NA 0.35 5.7 0.3 2.68e-8 Total body bone mineral density; CRC cis rs597539 0.690 rs635529 chr11:68626294 C/T cg06028808 chr11:68637592 NA 0.38 5.81 0.31 1.47e-8 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs3126085 0.935 rs3126094 chr1:152308243 T/C cg09127314 chr1:152161683 NA -0.49 -6.35 -0.33 7.27e-10 Atopic dermatitis; CRC cis rs2243480 1.000 rs4718309 chr7:65627764 G/C cg18252515 chr7:66147081 NA 1.23 14.38 0.62 9.77e-37 Diabetic kidney disease; CRC cis rs67311347 1.000 rs13073003 chr3:40504326 C/T cg24209194 chr3:40518798 ZNF619 -0.43 -6.48 -0.34 3.43e-10 Renal cell carcinoma; CRC cis rs11764590 0.715 rs55770986 chr7:2087823 T/C cg23378565 chr7:2036160 MAD1L1 -0.4 -5.67 -0.3 3.18e-8 Neuroticism; CRC cis rs1524976 1.000 rs11719771 chr3:65481987 G/T cg16238336 chr3:65465873 MAGI1 -0.52 -7.16 -0.37 5.43e-12 PR interval; CRC cis rs11650494 0.831 rs8065389 chr17:47456064 G/T cg08112188 chr17:47440006 ZNF652 -0.98 -10.19 -0.49 2.32e-21 Prostate cancer; CRC cis rs10504229 0.861 rs59873610 chr8:58172290 T/A cg02725872 chr8:58115012 NA -0.38 -6.48 -0.34 3.41e-10 Developmental language disorder (linguistic errors); CRC cis rs7914558 1.000 rs11191542 chr10:104824324 T/A cg04362960 chr10:104952993 NT5C2 0.6 9.12 0.45 7.86e-18 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg25858261 chr10:12085058 UPF2 0.49 7.45 0.38 8.56e-13 Intelligence (multi-trait analysis); CRC cis rs10504229 0.953 rs66815941 chr8:58187306 C/T cg24829409 chr8:58192753 C8orf71 -0.68 -11.34 -0.53 2.27e-25 Developmental language disorder (linguistic errors); CRC cis rs8141529 0.664 rs5762861 chr22:29250505 T/G cg15103426 chr22:29168792 CCDC117 0.49 6.34 0.33 7.65e-10 Lymphocyte counts; CRC cis rs7932354 0.502 rs10769244 chr11:47182368 A/G cg03339077 chr11:47165057 C11orf49 -0.48 -6.56 -0.34 2.09e-10 Bone mineral density (hip);Bone mineral density; CRC cis rs7587476 0.906 rs17487792 chr2:215643500 A/G cg04004882 chr2:215674386 BARD1 -0.56 -6.84 -0.35 3.91e-11 Neuroblastoma; CRC cis rs4594175 0.962 rs72688734 chr14:51634618 T/C cg23942311 chr14:51606299 NA 0.6 9.29 0.46 2.24e-18 Cancer; CRC cis rs734999 0.549 rs2764845 chr1:2528999 G/T cg18854424 chr1:2615690 NA -0.5 -9.85 -0.48 3.03e-20 Ulcerative colitis; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg02371369 chr7:102074135 ORAI2 0.44 6.81 0.35 4.52e-11 Liver disease severity in Alagille syndrome; CRC cis rs728616 0.867 rs723191 chr10:81707920 A/G cg05935833 chr10:81318306 SFTPA2 -0.7 -7.74 -0.39 1.27e-13 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs6546324 0.625 rs2861644 chr2:67799964 A/G cg15745817 chr2:67799979 NA -0.55 -9.71 -0.47 9.4e-20 Endometriosis; CRC cis rs875971 1.000 rs6957199 chr7:65978519 T/C cg11764359 chr7:65958608 NA 0.63 10.26 0.49 1.34e-21 Aortic root size; CRC cis rs1552244 1.000 rs9849434 chr3:10133710 A/G cg13047869 chr3:10149882 C3orf24 -0.52 -7.42 -0.38 9.96e-13 Alzheimer's disease; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg10120645 chr8:125486635 RNF139 0.42 6.78 0.35 5.69e-11 Liver disease severity in Alagille syndrome; CRC cis rs1355223 0.545 rs7106831 chr11:34879542 T/C cg11058730 chr11:34937778 PDHX;APIP -0.43 -5.99 -0.31 5.37e-9 Systemic lupus erythematosus and Systemic sclerosis; CRC trans rs10504229 1.000 rs112272435 chr8:58170371 A/G cg04077850 chr5:125800366 GRAMD3 0.37 6.27 0.33 1.15e-9 Developmental language disorder (linguistic errors); CRC trans rs60843830 1.000 rs6709534 chr2:217334 G/C cg11347411 chr7:150020925 ACTR3C;LRRC61 0.59 8.93 0.44 3.18e-17 Spherical equivalent (joint analysis main effects and education interaction); CRC cis rs4563143 0.704 rs16961809 chr19:29226299 C/T cg14983838 chr19:29218262 NA 0.55 8.54 0.43 5.13e-16 Methadone dose in opioid dependence; CRC cis rs751728 0.664 rs943478 chr6:33750940 T/A cg25922239 chr6:33757077 LEMD2 0.47 6.99 0.36 1.58e-11 Crohn's disease; CRC cis rs853679 0.769 rs17720293 chr6:28214698 C/T cg26958806 chr6:27640298 NA 0.78 5.91 0.31 8.63e-9 Depression; CRC cis rs11864453 0.826 rs9941087 chr16:72118324 G/A cg01557791 chr16:72042693 DHODH -0.52 -7.32 -0.37 1.89e-12 Fibrinogen levels; CRC cis rs9534288 0.797 rs7331069 chr13:46564609 A/T cg15192986 chr13:46630673 CPB2 0.65 9.41 0.46 9.1e-19 Blood protein levels; CRC trans rs2303319 0.504 rs1006427 chr2:162592328 T/C cg09481857 chr22:21368659 P2RX6;MGC16703 -0.65 -6.31 -0.33 9.13e-10 Cognitive function; CRC cis rs9322193 0.923 rs4870509 chr6:150023348 C/G cg05861140 chr6:150128134 PCMT1 -0.38 -5.96 -0.31 6.52e-9 Lung cancer; CRC cis rs5769765 0.908 rs138866 chr22:50205903 A/G cg02269571 chr22:50332266 NA 0.47 6.52 0.34 2.63e-10 Schizophrenia; CRC cis rs375066 0.623 rs7259647 chr19:44353383 T/C cg19542119 chr19:44331823 ZNF283 0.4 5.61 0.3 4.24e-8 Breast cancer; CRC cis rs11758351 0.587 rs16891466 chr6:26235737 G/A cg22723502 chr6:26240528 HIST1H4F -0.37 -5.9 -0.31 9.28e-9 Gout;Renal underexcretion gout; CRC cis rs950169 1.000 rs11638394 chr15:84778928 G/A cg17507749 chr15:85114479 UBE2QP1 0.77 11.97 0.55 1.2100000000000001e-27 Schizophrenia; CRC trans rs801193 1.000 rs3800812 chr7:66223461 T/C cg05627663 chr7:65219948 SNORA22;CCT6P1 0.41 6.05 0.32 4.01e-9 Aortic root size; CRC cis rs9322817 0.691 rs2499663 chr6:105300570 A/G cg02098413 chr6:105308735 HACE1 -0.41 -7.96 -0.4 2.88e-14 Thyroid stimulating hormone; CRC cis rs7914558 0.902 rs7092200 chr10:104844872 T/C cg15744005 chr10:104629667 AS3MT -0.31 -6.48 -0.34 3.31e-10 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs75920871 0.588 rs1815789 chr11:116834953 T/C cg01368799 chr11:117014884 PAFAH1B2 -0.42 -5.93 -0.31 7.55e-9 Subjective well-being; CRC cis rs8105895 0.935 rs7252023 chr19:22245646 C/G cg02657401 chr19:22469223 NA -0.34 -5.65 -0.3 3.56e-8 Body mass index (change over time); CRC cis rs6940638 0.688 rs9379960 chr6:27121325 A/C cg12292205 chr6:26970375 C6orf41 -0.48 -6.7 -0.35 9.22e-11 Intelligence (multi-trait analysis); CRC cis rs75557865 1 rs75557865 chr3:121652141 G/A cg20356878 chr3:121714668 ILDR1 0.64 12.88 0.58 5.26e-31 Allergic disease (asthma, hay fever or eczema); CRC cis rs2836974 0.568 rs442972 chr21:40534757 C/T cg22974920 chr21:40686053 BRWD1 -0.43 -6.12 -0.32 2.63e-9 Cognitive function; CRC trans rs3733585 0.673 rs7376948 chr4:9954708 G/A cg26043149 chr18:55253948 FECH -0.51 -7.78 -0.39 9.59e-14 Cleft plate (environmental tobacco smoke interaction); CRC cis rs892961 0.932 rs747481 chr17:75412143 A/G cg05865280 chr17:75406074 SEPT9 0.62 14.39 0.62 9.05e-37 Airflow obstruction; CRC cis rs9847710 1.000 rs4687697 chr3:53090490 C/T cg04503182 chr3:53078218 SFMBT1 -0.45 -7.18 -0.37 4.53e-12 Ulcerative colitis; CRC cis rs17711722 0.522 rs6957759 chr7:65271785 A/G cg00343986 chr7:65444356 GUSB 0.49 7.01 0.36 1.32e-11 Calcium levels; CRC cis rs4332037 0.707 rs62435130 chr7:1890002 C/T cg25834613 chr7:1915315 MAD1L1 -0.4 -6.21 -0.32 1.56e-9 Bipolar disorder; CRC cis rs873946 0.504 rs3829132 chr10:134579044 A/C cg06453172 chr10:134556979 INPP5A -0.58 -7.32 -0.37 1.91e-12 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CRC cis rs801193 0.569 rs6978178 chr7:66123084 G/A cg12463550 chr7:65579703 CRCP -0.46 -6.14 -0.32 2.4e-9 Aortic root size; CRC cis rs1555322 0.505 rs591590 chr20:33866028 A/G cg07134254 chr20:33865797 NA -0.44 -5.7 -0.3 2.71e-8 Attention deficit hyperactivity disorder; CRC cis rs9287719 0.601 rs759401 chr2:10709922 G/A cg00105475 chr2:10696890 NA 0.48 7.39 0.38 1.23e-12 Prostate cancer; CRC cis rs651907 0.535 rs4342086 chr3:101503765 G/A cg12386194 chr3:101231763 SENP7 0.53 7.75 0.39 1.15e-13 Colorectal cancer; CRC trans rs9956878 0.555 rs8085188 chr18:73544676 A/G cg14577476 chr17:49337432 MBTD1;UTP18 -0.36 -6.06 -0.32 3.75e-9 Obesity-related traits; CRC cis rs6912958 0.728 rs7773906 chr6:88251869 T/A cg08069147 chr6:88032118 GJB7;C6orf162 -0.56 -8.43 -0.42 1.12e-15 Monocyte percentage of white cells; CRC trans rs459571 0.959 rs455381 chr9:136905577 C/A cg09836344 chr4:1243392 C4orf42;CTBP1 -0.81 -11.14 -0.52 1.17e-24 Platelet distribution width; CRC cis rs9611565 0.592 rs5751139 chr22:42099981 G/C cg06634786 chr22:41940651 POLR3H 0.63 7.17 0.37 4.99e-12 Vitiligo; CRC cis rs853679 0.517 rs9468298 chr6:28122345 A/G cg02631126 chr6:28058918 ZSCAN12L1 0.29 5.91 0.31 8.38e-9 Depression; CRC cis rs6598955 0.724 rs12068388 chr1:26621596 G/A cg04990556 chr1:26633338 UBXN11 -0.79 -13.0 -0.58 1.84e-31 Obesity-related traits; CRC cis rs910316 1.000 rs7156328 chr14:75532941 T/C cg08847533 chr14:75593920 NEK9 0.92 17.18 0.69 1.15e-47 Height; CRC cis rs4665809 1.000 rs6720314 chr2:26334852 G/A cg27170947 chr2:26402098 FAM59B -0.46 -5.89 -0.31 9.71e-9 Gut microbiome composition (summer); CRC cis rs68170813 0.559 rs6971675 chr7:106833797 G/A cg02696742 chr7:106810147 HBP1 -0.61 -6.78 -0.35 5.75e-11 Coronary artery disease; CRC cis rs847577 0.588 rs6946915 chr7:97711340 C/G cg00277769 chr7:97922759 BAIAP2L1 -0.42 -7.18 -0.37 4.71e-12 Breast cancer; CRC cis rs3749237 0.595 rs3870337 chr3:49557095 G/T cg02487422 chr3:49467188 NICN1 0.42 6.79 0.35 5.35e-11 Resting heart rate; CRC cis rs6461049 0.800 rs1860831 chr7:2160931 T/C cg22963979 chr7:1858916 MAD1L1 -0.39 -5.89 -0.31 9.37e-9 Schizophrenia; CRC cis rs55665837 1.000 rs2305306 chr11:14534999 T/A cg19336497 chr11:14380999 RRAS2 -0.39 -6.46 -0.34 3.79e-10 Vitamin D levels; CRC cis rs2637266 0.514 rs11001862 chr10:78474147 A/G cg18941641 chr10:78392320 NA 0.34 6.0 0.31 5.3300000000000004e-09 Pulmonary function; CRC cis rs4665809 0.590 rs7588328 chr2:26469788 G/A cg27170947 chr2:26402098 FAM59B 0.6 7.82 0.4 7.45e-14 Gut microbiome composition (summer); CRC cis rs6964587 1.000 rs10228800 chr7:91610111 T/G cg17063962 chr7:91808500 NA 0.8 14.26 0.62 3.07e-36 Breast cancer; CRC cis rs72772090 0.539 rs11747148 chr5:96112863 C/T cg17330273 chr5:96107758 CAST;ERAP1 -0.66 -6.04 -0.32 4.12e-9 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC trans rs6860806 0.507 rs169256 chr5:131688533 A/G cg19540316 chr13:113622750 MCF2L 0.47 6.12 0.32 2.7e-9 Breast cancer; CRC cis rs758324 0.947 rs2404778 chr5:131172886 T/C cg06307176 chr5:131281290 NA 0.43 6.52 0.34 2.59e-10 Alzheimer's disease in APOE e4- carriers; CRC cis rs7829975 0.714 rs12544992 chr8:8661681 C/G cg06636001 chr8:8085503 FLJ10661 0.64 10.15 0.49 2.99e-21 Mood instability; CRC cis rs9322193 0.923 rs57938011 chr6:149964105 T/A cg13206674 chr6:150067644 NUP43 0.67 9.63 0.47 1.65e-19 Lung cancer; CRC cis rs4731207 0.596 rs10276834 chr7:124607549 A/T cg23710748 chr7:124431027 NA -0.38 -6.08 -0.32 3.35e-9 Cutaneous malignant melanoma; CRC cis rs2749592 0.531 rs994804 chr10:37900140 A/C cg25427524 chr10:38739819 LOC399744 0.66 10.99 0.52 4e-24 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs875971 1.000 rs1968225 chr7:65874773 T/C cg18912574 chr7:65842487 NCRNA00174 0.36 6.18 0.32 1.88e-9 Aortic root size; CRC cis rs6960043 0.818 rs10807778 chr7:15054190 C/G cg19272540 chr7:15055459 NA 0.24 6.67 0.35 1.06e-10 Type 2 diabetes; CRC cis rs9560113 0.509 rs4773390 chr13:112208904 G/A cg10483660 chr13:112241077 NA 0.56 10.13 0.49 3.61e-21 Menarche (age at onset); CRC cis rs7786808 0.653 rs7810861 chr7:158212633 G/A cg01191920 chr7:158217561 PTPRN2 -0.66 -10.52 -0.5 1.67e-22 Obesity-related traits; CRC cis rs7605827 0.897 rs7564514 chr2:15654808 G/A cg19274914 chr2:15703543 NA 0.4 6.0 0.31 5.16e-9 Educational attainment (years of education); CRC cis rs1799949 1.000 rs4793215 chr17:41318932 G/A cg23758822 chr17:41437982 NA 0.81 13.32 0.59 1.11e-32 Menopause (age at onset); CRC trans rs7395662 0.500 rs10838984 chr11:48640485 C/T cg15704280 chr7:45808275 SEPT13 -0.5 -7.17 -0.37 5.11e-12 HDL cholesterol; CRC cis rs847649 0.621 rs2222539 chr7:102674786 G/A cg18108683 chr7:102477205 FBXL13 0.54 8.48 0.42 7.88e-16 Morning vs. evening chronotype; CRC cis rs7107174 1.000 rs7939352 chr11:78003151 G/A cg02023728 chr11:77925099 USP35 0.49 8.56 0.43 4.3e-16 Testicular germ cell tumor; CRC cis rs11785400 0.793 rs4587307 chr8:143738529 G/A cg24634471 chr8:143751801 JRK 0.48 6.52 0.34 2.63e-10 Schizophrenia; CRC cis rs1816752 0.683 rs7330532 chr13:25017591 C/T cg02811702 chr13:24901961 NA 0.48 6.6 0.34 1.68e-10 Obesity-related traits; CRC trans rs3942852 0.568 rs10838800 chr11:48094879 C/T cg03929089 chr4:120376271 NA -0.6 -8.4 -0.42 1.38e-15 Acute lymphoblastic leukemia (childhood); CRC cis rs4253772 0.591 rs6007747 chr22:46657261 A/G cg03482458 chr22:46692211 CN5H6.4;GTSE1 0.55 7.3 0.37 2.18e-12 LDL cholesterol;Cholesterol, total; CRC cis rs3741404 0.560 rs12362602 chr11:63908660 G/A cg18225595 chr11:63971243 STIP1 -0.47 -7.61 -0.39 2.87e-13 Platelet count; CRC trans rs77926410 0.929 rs12826560 chr12:10532965 T/C cg23926866 chr1:1058658 NA 0.52 6.11 0.32 2.78e-9 Mean corpuscular volume; CRC cis rs780096 0.526 rs1647276 chr2:27688601 C/T cg22903471 chr2:27725779 GCKR -0.37 -6.06 -0.32 3.65e-9 Total body bone mineral density; CRC cis rs11098499 0.754 rs7689729 chr4:120256192 A/G cg09307838 chr4:120376055 NA 0.62 9.63 0.47 1.68e-19 Corneal astigmatism; CRC cis rs7542091 0.704 rs7550330 chr1:210044587 G/A cg22029157 chr1:209979665 IRF6 0.47 7.4 0.38 1.11e-12 Monobrow; CRC cis rs1018836 0.892 rs7819519 chr8:91565504 C/T cg16814680 chr8:91681699 NA -0.59 -9.11 -0.45 8.37e-18 Ejection fraction in Tripanosoma cruzi seropositivity; CRC cis rs3806843 1.000 rs11167600 chr5:140174865 G/C cg16607685 chr5:140181889 PCDHA2;PCDHA1;PCDHA3 -0.27 -6.27 -0.33 1.14e-9 Depressive symptoms (multi-trait analysis); CRC trans rs10504229 1.000 rs17216648 chr8:58169429 C/T cg04077850 chr5:125800366 GRAMD3 0.38 6.44 0.33 4.14e-10 Developmental language disorder (linguistic errors); CRC cis rs1862618 0.525 rs2662021 chr5:56261691 C/T cg20203395 chr5:56204925 C5orf35 0.69 8.31 0.42 2.5e-15 Initial pursuit acceleration; CRC cis rs910316 1.000 rs4903281 chr14:75554361 G/C cg08847533 chr14:75593920 NEK9 0.93 17.79 0.7 4.27e-50 Height; CRC cis rs950169 0.580 rs62021208 chr15:85196244 G/A cg17507749 chr15:85114479 UBE2QP1 0.64 9.16 0.45 5.61e-18 Schizophrenia; CRC trans rs916888 0.647 rs199523 chr17:44848517 C/A cg22433210 chr17:43662623 NA -0.58 -7.08 -0.36 8.55e-12 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs875971 0.964 rs778723 chr7:65829497 T/C cg00343986 chr7:65444356 GUSB 0.43 6.3 0.33 9.66e-10 Aortic root size; CRC cis rs7493 1.000 rs6961773 chr7:95037718 T/G cg21856205 chr7:94953877 PON1 -0.51 -6.66 -0.34 1.16e-10 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs1008375 0.966 rs10489036 chr4:17697687 A/G cg04450456 chr4:17643702 FAM184B 0.36 5.65 0.3 3.44e-8 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs7208859 0.524 rs73988172 chr17:29086332 A/C cg13385521 chr17:29058706 SUZ12P 0.7 8.15 0.41 7.6e-15 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs736408 0.609 rs13095332 chr3:52787242 C/T cg18099408 chr3:52552593 STAB1 -0.44 -7.21 -0.37 3.86e-12 Bipolar disorder; CRC cis rs7216064 0.648 rs61676547 chr17:65892507 G/C cg12091567 chr17:66097778 LOC651250 -0.59 -7.24 -0.37 3.15e-12 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CRC cis rs2836974 0.932 rs2234543 chr21:40572072 G/A cg06238570 chr21:40685208 BRWD1 0.78 10.7 0.51 3.88e-23 Cognitive function; CRC cis rs1580019 0.587 rs34488151 chr7:32548146 A/G cg06627557 chr7:32535165 LSM5;AVL9 0.97 18.91 0.72 1.7e-54 Cognitive ability; CRC cis rs453301 0.653 rs1562211 chr8:8902424 A/G cg06636001 chr8:8085503 FLJ10661 -0.48 -7.44 -0.38 9.1e-13 Joint mobility (Beighton score); CRC cis rs2019137 0.936 rs3828188 chr2:113954247 G/A cg21482265 chr2:113992762 PAX8;LOC440839;LOC654433 -0.46 -6.57 -0.34 1.94e-10 Lymphocyte counts; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg01855760 chr4:68567075 LOC550112;UBA6 0.51 7.3 0.37 2.23e-12 Response to antipsychotic treatment; CRC cis rs910316 0.967 rs2268619 chr14:75640354 C/G cg11812906 chr14:75593930 NEK9 -0.63 -9.24 -0.45 3.08e-18 Height; CRC cis rs10504229 0.679 rs11783444 chr8:58131267 A/G cg04204079 chr8:58130323 NA -0.45 -5.78 -0.3 1.71e-8 Developmental language disorder (linguistic errors); CRC cis rs644799 0.540 rs10831419 chr11:95478037 A/G cg25622487 chr11:95524042 FAM76B;CEP57 0.48 6.53 0.34 2.51e-10 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs9902453 0.765 rs2447935 chr17:28057524 A/G cg26525008 chr17:28256777 EFCAB5;SSH2 -0.71 -11.98 -0.55 1.12e-27 Coffee consumption (cups per day); CRC cis rs4889855 0.530 rs78012645 chr17:78550939 C/T cg16591659 chr17:78472290 NA 0.41 5.97 0.31 6.24e-9 Fractional excretion of uric acid; CRC cis rs929596 0.785 rs17864701 chr2:234652717 C/T cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.75 -11.07 -0.52 1.96e-24 Total bilirubin levels in HIV-1 infection; CRC cis rs6570726 0.620 rs12201226 chr6:145913419 A/T cg23711669 chr6:146136114 FBXO30 0.63 9.23 0.45 3.27e-18 Lobe attachment (rater-scored or self-reported); CRC cis rs13191362 1.000 rs34594856 chr6:163051845 C/T cg14584255 chr6:163149320 PACRG;PARK2 0.43 6.17 0.32 1.96e-9 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs11098499 0.687 rs71610270 chr4:120287436 A/G cg09307838 chr4:120376055 NA 0.67 10.24 0.49 1.52e-21 Corneal astigmatism; CRC cis rs769267 0.899 rs67720221 chr19:19440864 C/T cg01262667 chr19:19385393 TM6SF2 -0.37 -6.05 -0.32 3.87e-9 Tonsillectomy; CRC trans rs7395662 0.500 rs1304199 chr11:48699032 A/G cg21153622 chr11:89784906 NA -0.52 -8.85 -0.44 5.58e-17 HDL cholesterol; CRC trans rs1814175 0.817 rs10839351 chr11:49758153 C/T cg11707556 chr5:10655725 ANKRD33B -0.41 -7.6 -0.39 3.03e-13 Height; CRC cis rs7949030 1.000 rs7949030 chr11:62394881 A/G cg22862634 chr11:62369728 EML3;MTA2 0.48 8.23 0.41 4.5e-15 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; CRC cis rs1256061 0.624 rs944047 chr14:64700292 C/T cg23250157 chr14:64679961 SYNE2 0.46 7.13 0.37 6.4e-12 Hemoglobin concentration;Red blood cell count;Hematocrit; CRC trans rs7618501 1.000 rs2234391 chr3:49842625 A/G cg21665057 chr3:196295764 WDR53;FBXO45 0.82 15.05 0.64 2.65e-39 Intelligence (multi-trait analysis); CRC cis rs7312933 0.558 rs1796394 chr12:42826359 G/A cg19980929 chr12:42632907 YAF2 -0.41 -6.25 -0.33 1.27e-9 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CRC cis rs172166 0.611 rs203883 chr6:28078356 A/G cg21251018 chr6:28226885 NKAPL 0.47 7.07 0.36 9.43e-12 Cardiac Troponin-T levels; CRC cis rs7937682 0.889 rs1789359 chr11:111475995 T/A cg09085632 chr11:111637200 PPP2R1B -0.98 -19.21 -0.73 1.09e-55 Primary sclerosing cholangitis; CRC cis rs1046896 0.519 rs9900369 chr17:80829807 G/A cg08200770 chr17:80723486 TBCD -0.5 -7.65 -0.39 2.3e-13 Glycated hemoglobin levels; CRC cis rs12995491 0.731 rs17435433 chr2:88509616 A/G cg04511125 chr2:88470314 THNSL2 -0.4 -5.77 -0.3 1.79e-8 Response to metformin (IC50); CRC trans rs3858526 0.916 rs11039551 chr11:5930773 C/T cg01505111 chr6:125621795 HDDC2 0.4 6.42 0.33 4.73e-10 DNA methylation (variation); CRC cis rs877282 0.741 rs35865720 chr10:753022 G/A cg17470449 chr10:769945 NA 0.6 7.76 0.39 1.06e-13 Uric acid levels; CRC cis rs9894429 0.550 rs6565617 chr17:79612333 G/A cg21984481 chr17:79567631 NPLOC4 -0.44 -7.57 -0.39 3.77e-13 Eye color traits; CRC cis rs6540556 0.723 rs1000282 chr1:209894785 T/C cg05527609 chr1:210001259 C1orf107 -0.57 -6.21 -0.32 1.59e-9 Red blood cell count; CRC cis rs6912958 0.781 rs9450752 chr6:88300013 A/G cg12350822 chr6:88032061 C6orf162;GJB7 -0.34 -6.37 -0.33 6.44e-10 Monocyte percentage of white cells; CRC cis rs1223397 0.651 rs2439535 chr6:13305822 C/T cg20827128 chr6:13274284 PHACTR1 0.4 6.01 0.31 4.87e-9 Blood pressure; CRC cis rs6860806 0.661 rs2171247 chr5:131580234 G/T cg12564285 chr5:131593104 PDLIM4 0.47 9.02 0.45 1.65e-17 Breast cancer; CRC cis rs270601 0.837 rs367805 chr5:131701279 T/C cg09877947 chr5:131593287 PDLIM4 0.43 7.06 0.36 9.99e-12 Acylcarnitine levels; CRC trans rs916888 0.773 rs199534 chr17:44824213 T/G cg10053473 chr17:62856997 LRRC37A3 -0.84 -8.92 -0.44 3.35e-17 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs9341808 0.667 rs7745301 chr6:80922561 G/T cg08355045 chr6:80787529 NA 0.33 5.69 0.3 2.83e-8 Sitting height ratio; CRC trans rs875971 0.660 rs2191268 chr7:66110224 C/T cg22783262 chr22:45098346 PRR5-ARHGAP8;PRR5 -0.4 -6.31 -0.33 8.96e-10 Aortic root size; CRC cis rs2976388 0.669 rs2976391 chr8:143762724 C/A cg04969067 chr8:143858791 LYNX1 0.36 6.01 0.31 4.85e-9 Urinary tract infection frequency; CRC trans rs9813712 0.597 rs10934931 chr3:129980208 C/T cg23942268 chr17:6347992 FAM64A -0.42 -6.13 -0.32 2.5e-9 Response to amphetamines; CRC cis rs1218582 0.741 rs11264281 chr1:154867221 A/G cg03351412 chr1:154909251 PMVK 0.51 7.69 0.39 1.76e-13 Prostate cancer; CRC cis rs7487075 0.786 rs7316127 chr12:46674249 A/C cg22049899 chr12:47219821 SLC38A4 0.32 5.83 0.31 1.33e-8 Itch intensity from mosquito bite; CRC cis rs2120019 1.000 rs12324912 chr15:75361006 G/A cg09165964 chr15:75287851 SCAMP5 -0.82 -13.01 -0.58 1.66e-31 Blood trace element (Zn levels); CRC cis rs9443189 0.570 rs9343316 chr6:76411800 G/A cg01950844 chr6:76311363 SENP6 0.74 9.84 0.48 3.35e-20 Prostate cancer; CRC cis rs11671005 0.695 rs8106061 chr19:58917990 G/C cg26874164 chr19:58962979 ZNF324B 0.8 11.88 0.55 2.56e-27 Mean platelet volume; CRC cis rs6952808 0.692 rs11765549 chr7:2027311 G/T cg02951883 chr7:2050386 MAD1L1 -0.79 -12.78 -0.58 1.23e-30 Bipolar disorder and schizophrenia; CRC cis rs990171 0.954 rs6543137 chr2:103065908 T/G cg03938978 chr2:103052716 IL18RAP 0.46 5.89 0.31 9.32e-9 Lymphocyte counts; CRC cis rs9322193 0.736 rs3805750 chr6:150112201 G/A cg13206674 chr6:150067644 NUP43 0.57 8.16 0.41 7.39e-15 Lung cancer; CRC cis rs4144743 0.938 rs35069360 chr17:45321270 C/T cg18085866 chr17:45331354 ITGB3 -0.59 -8.02 -0.4 1.86e-14 Body mass index; CRC cis rs4332037 0.707 rs73046323 chr7:1882795 G/A cg21155852 chr7:2048760 MAD1L1 -0.42 -6.01 -0.31 4.8e-9 Bipolar disorder; CRC cis rs9611565 0.625 rs12483991 chr22:41935285 A/G cg06634786 chr22:41940651 POLR3H -0.6 -7.51 -0.38 5.76e-13 Vitiligo; CRC cis rs9929218 1.000 rs13330350 chr16:68800849 C/T cg02972257 chr16:68554789 NA 0.44 5.61 0.3 4.28e-8 Colorectal cancer; CRC cis rs599083 0.530 rs491347 chr11:68169688 G/A cg16797656 chr11:68205561 LRP5 -0.39 -6.23 -0.32 1.46e-9 Bone mineral density (spine); CRC cis rs644148 0.785 rs118112019 chr19:44965091 T/G cg15540054 chr19:45004280 ZNF180 0.51 6.71 0.35 8.58e-11 Personality dimensions; CRC cis rs317689 0.513 rs529268 chr12:69687051 G/A cg14784868 chr12:69753453 YEATS4 0.64 9.82 0.48 3.9e-20 Response to diuretic therapy; CRC cis rs1261795 1.000 rs1261795 chr14:21505628 C/T cg04957377 chr14:21507259 NA -0.31 -5.73 -0.3 2.23e-8 Pediatric bone mineral content (radius); CRC cis rs17001868 0.568 rs3788579 chr22:40742989 T/C cg07138101 chr22:40742427 ADSL 0.59 7.8 0.4 8.21e-14 Mammographic density (dense area); CRC cis rs7212590 1.000 rs7212590 chr17:57885709 C/T cg10252138 chr17:58120427 NA -0.54 -5.73 -0.3 2.32e-8 Granulocyte percentage of myeloid white cells;Monocyte count;Monocyte percentage of white cells; CRC trans rs6951245 1.000 rs76214082 chr7:1102097 T/A cg13565492 chr6:43139072 SRF -0.72 -7.44 -0.38 8.63e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs7727544 0.571 rs12521097 chr5:131575338 G/A cg11843238 chr5:131593191 PDLIM4 0.33 6.31 0.33 9.26e-10 Blood metabolite levels; CRC cis rs2836974 0.605 rs2836971 chr21:40652040 A/C cg11890956 chr21:40555474 PSMG1 -0.91 -15.92 -0.66 1.01e-42 Cognitive function; CRC cis rs9611565 0.802 rs2234058 chr22:41777883 G/A cg06634786 chr22:41940651 POLR3H -0.68 -7.81 -0.4 7.69e-14 Vitiligo; CRC cis rs2630709 0.562 rs3102959 chr2:8461625 C/G cg12167548 chr2:8464763 NA 0.33 6.25 0.33 1.26e-9 Monocyte percentage of white cells; CRC cis rs8180040 1.000 rs295461 chr3:47368010 T/C cg02527881 chr3:46936655 PTH1R -0.4 -7.66 -0.39 2.09e-13 Colorectal cancer; CRC cis rs6662572 0.737 rs74523130 chr1:46599619 C/T cg08644498 chr1:46502608 NA 0.44 6.99 0.36 1.57e-11 Blood protein levels; CRC trans rs10504229 0.906 rs6990615 chr8:58182956 G/A cg04077850 chr5:125800366 GRAMD3 0.37 6.27 0.33 1.15e-9 Developmental language disorder (linguistic errors); CRC cis rs6502050 0.835 rs62080004 chr17:80079079 C/T cg13198984 chr17:80129470 CCDC57 -0.48 -8.58 -0.43 3.8e-16 Life satisfaction; CRC cis rs6502050 0.805 rs4789721 chr17:80157453 T/C cg22110888 chr17:80059540 CCDC57 0.38 6.01 0.31 5.06e-9 Life satisfaction; CRC cis rs7917772 0.503 rs11191326 chr10:104302959 C/T cg04362960 chr10:104952993 NT5C2 -0.41 -5.79 -0.3 1.62e-8 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC cis rs1728785 0.901 rs1645974 chr16:68564774 C/G cg02972257 chr16:68554789 NA -0.58 -7.08 -0.36 9.03e-12 Ulcerative colitis; CRC trans rs17150703 0.630 rs12545481 chr8:9747377 G/A cg06636001 chr8:8085503 FLJ10661 0.53 6.49 0.34 3.2e-10 Obesity (early onset extreme); CRC cis rs3741404 0.620 rs882147 chr11:63976689 T/A cg06219103 chr11:63990595 FERMT3 -0.44 -6.88 -0.35 3.12e-11 Platelet count; CRC cis rs6674176 0.593 rs3791120 chr1:44431715 T/C cg13606994 chr1:44402422 ARTN -0.34 -5.76 -0.3 1.94e-8 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Cognitive ability; CRC cis rs11628318 0.614 rs7145737 chr14:103121784 T/A cg23461800 chr14:103021989 NA 0.69 7.84 0.4 6.5e-14 Platelet count; CRC trans rs12599106 0.660 rs12919333 chr16:34991336 C/T cg01171360 chr6:293285 DUSP22 -0.55 -7.83 -0.4 6.84e-14 Menopause (age at onset); CRC cis rs174601 0.582 rs108499 chr11:61547237 C/T cg00603274 chr11:61596626 FADS2 -0.45 -6.49 -0.34 3.21e-10 Blood metabolite levels;Red blood cell fatty acid levels;Liver enzyme levels (alkaline phosphatase);Gondoic acid (20:1n-9) levels;Trans fatty acid levels; CRC cis rs1348850 0.632 rs12467363 chr2:178502512 C/T cg22681709 chr2:178499509 PDE11A -0.51 -9.47 -0.46 5.55e-19 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs6754311 0.773 rs309179 chr2:136613780 G/A cg25344623 chr2:136566232 LCT 0.33 5.98 0.31 5.97e-9 Mosquito bite size; CRC cis rs7726839 0.540 rs57306627 chr5:597643 T/C cg09021430 chr5:549028 NA -0.7 -8.17 -0.41 6.68e-15 Obesity-related traits; CRC cis rs1364705 1.000 rs13262685 chr8:120226145 A/G cg27215916 chr8:120218354 NA -0.39 -5.9 -0.31 8.85e-9 Hippocampal atrophy; CRC cis rs4237845 0.837 rs7971877 chr12:58287630 T/G cg00677455 chr12:58241039 CTDSP2 0.55 8.08 0.41 1.24e-14 Intelligence (multi-trait analysis); CRC cis rs992157 0.835 rs12987180 chr2:219144089 G/A cg04731861 chr2:219085781 ARPC2 0.33 6.95 0.36 2.01e-11 Colorectal cancer; CRC cis rs4509693 0.943 rs6584395 chr10:102498008 G/C cg23167259 chr10:102495509 NA -0.47 -6.35 -0.33 6.97e-10 Alzheimer's disease; CRC cis rs10782582 0.586 rs112368938 chr1:76336339 C/T cg10523679 chr1:76189770 ACADM -0.4 -5.63 -0.3 3.86e-8 Daytime sleep phenotypes; CRC cis rs6502050 0.835 rs8077926 chr17:80117315 C/A cg09264619 chr17:80180166 NA -0.35 -5.98 -0.31 5.97e-9 Life satisfaction; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg08767708 chr16:73082503 ZFHX3 0.39 6.0 0.31 5.2e-9 Intelligence (multi-trait analysis); CRC cis rs5750830 0.546 rs4821891 chr22:39785381 C/T cg05872129 chr22:39784769 NA -0.62 -12.06 -0.55 5.36e-28 Intelligence (multi-trait analysis); CRC cis rs12681288 0.523 rs6983944 chr8:955147 A/G cg04851639 chr8:1020857 NA -0.29 -5.9 -0.31 9.03e-9 Schizophrenia; CRC cis rs4604732 0.631 rs34443739 chr1:247626913 A/G cg12758973 chr1:247694275 LOC148824;OR2C3 0.42 6.21 0.32 1.63e-9 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CRC cis rs10857712 0.754 rs2297032 chr10:135234580 C/T cg01444801 chr10:135216882 MTG1 -0.55 -7.82 -0.4 7.4e-14 Systemic lupus erythematosus; CRC cis rs9549328 0.589 rs34144481 chr13:113617322 T/G cg25790453 chr13:113633590 MCF2L 0.44 7.56 0.38 3.94e-13 Systolic blood pressure; CRC trans rs11039798 0.588 rs12294395 chr11:48476860 C/T cg15704280 chr7:45808275 SEPT13 0.64 6.48 0.34 3.44e-10 Axial length; CRC cis rs4713118 0.868 rs9468220 chr6:27732976 A/G cg20933634 chr6:27740509 NA -0.63 -7.29 -0.37 2.29e-12 Parkinson's disease; CRC cis rs2012796 0.872 rs59397507 chr14:81821334 A/G cg02996355 chr14:81879375 NA 0.55 8.12 0.41 9.36e-15 Night sleep phenotypes; CRC cis rs6860806 0.507 rs272882 chr5:131669161 G/T cg22638593 chr5:131593259 PDLIM4 0.38 6.24 0.33 1.33e-9 Breast cancer; CRC cis rs4713118 0.513 rs156734 chr6:28007357 A/C cg23161317 chr6:28129485 ZNF389 0.45 6.51 0.34 2.82e-10 Parkinson's disease; CRC cis rs9733 0.650 rs6698495 chr1:150564476 T/C cg18016565 chr1:150552671 MCL1 -0.47 -7.01 -0.36 1.35e-11 Tonsillectomy; CRC cis rs950169 0.922 rs4842946 chr15:84942331 G/A cg11189052 chr15:85197271 WDR73 0.63 8.8 0.44 7.65e-17 Schizophrenia; CRC cis rs6460942 0.841 rs62448597 chr7:12449110 G/C cg06484146 chr7:12443880 VWDE -0.8 -8.59 -0.43 3.55e-16 Coronary artery disease; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg05592363 chr5:78908495 PAPD4 0.39 6.06 0.32 3.72e-9 Liver disease severity in Alagille syndrome; CRC cis rs2243480 1.000 rs1873494 chr7:65649899 T/C cg18252515 chr7:66147081 NA 1.23 14.37 0.62 1.07e-36 Diabetic kidney disease; CRC cis rs9486719 1.000 rs2472889 chr6:96866803 T/G cg06623918 chr6:96969491 KIAA0776 0.81 9.48 0.46 5.18e-19 Migraine;Coronary artery disease; CRC cis rs9462027 0.628 rs2744957 chr6:34618516 T/C cg07306190 chr6:34760872 UHRF1BP1 -0.35 -6.31 -0.33 9.16e-10 Systemic lupus erythematosus; CRC cis rs174601 0.721 rs174530 chr11:61546592 A/G cg00603274 chr11:61596626 FADS2 -0.41 -6.14 -0.32 2.43e-9 Blood metabolite levels;Red blood cell fatty acid levels;Liver enzyme levels (alkaline phosphatase);Gondoic acid (20:1n-9) levels;Trans fatty acid levels; CRC cis rs6502050 0.799 rs4789680 chr17:80100547 C/A cg25804541 chr17:80189381 SLC16A3 -0.31 -5.97 -0.31 6.08e-9 Life satisfaction; CRC cis rs8180040 0.967 rs4858856 chr3:47565424 G/A cg27129171 chr3:47204927 SETD2 0.51 7.96 0.4 2.89e-14 Colorectal cancer; CRC cis rs10795061 0.576 rs10904074 chr10:3710962 G/A cg22632523 chr10:3711048 NA 0.6 7.53 0.38 5.03e-13 Subjective well-being; CRC cis rs6831352 0.838 rs2851250 chr4:100044113 G/C cg13256891 chr4:100009986 ADH5 0.65 8.7 0.43 1.65e-16 Alcohol dependence; CRC cis rs9611565 0.879 rs2235845 chr22:41729294 T/G cg06634786 chr22:41940651 POLR3H -0.41 -5.61 -0.3 4.25e-8 Vitiligo; CRC trans rs9291683 0.588 rs6844329 chr4:10018544 T/C cg26043149 chr18:55253948 FECH 0.51 7.91 0.4 3.95e-14 Bone mineral density; CRC cis rs1552244 0.882 rs3755783 chr3:10029289 A/G cg16606324 chr3:10149918 C3orf24 0.56 6.82 0.35 4.44e-11 Alzheimer's disease; CRC cis rs208520 0.837 rs208489 chr6:66927584 G/A cg07460842 chr6:66804631 NA -0.95 -12.37 -0.56 4.11e-29 Exhaled nitric oxide output; CRC trans rs6951245 0.638 rs4720486 chr7:1146764 G/A cg13565492 chr6:43139072 SRF -0.84 -10.53 -0.5 1.61e-22 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs6831352 0.877 rs2602890 chr4:100043179 C/T cg13256891 chr4:100009986 ADH5 0.67 9.15 0.45 6.18e-18 Alcohol dependence; CRC cis rs727505 0.866 rs66852389 chr7:124724348 T/A cg23710748 chr7:124431027 NA -0.72 -12.33 -0.56 5.81e-29 Lewy body disease; CRC cis rs6951245 0.554 rs75075857 chr7:1140298 C/T cg21664854 chr7:1097933 C7orf50;GPR146 0.58 7.34 0.38 1.66e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs4631830 0.747 rs745180 chr10:51504493 A/C cg20129853 chr10:51489980 NA 0.36 5.94 0.31 7.16e-9 Prostate-specific antigen levels; CRC cis rs904251 0.525 rs12200378 chr6:37425304 A/G cg25019722 chr6:37503610 NA -0.38 -6.73 -0.35 7.65e-11 Cognitive performance; CRC cis rs10991814 0.920 rs7852934 chr9:94112399 T/C cg14446406 chr9:93919335 NA 0.59 6.66 0.34 1.13e-10 Neutrophil percentage of granulocytes; CRC cis rs6951245 0.706 rs28522260 chr7:1183964 C/A cg26224354 chr7:1096374 C7orf50;GPR146 -0.82 -10.69 -0.51 4.23e-23 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs78456975 1.000 rs13431491 chr2:1553808 T/A cg01028140 chr2:1542097 TPO -0.55 -5.7 -0.3 2.72e-8 Placebo response in major depressive disorder (% change in symptom score); CRC cis rs116095464 0.558 rs10055354 chr5:243794 G/A cg22857025 chr5:266934 NA -1.25 -16.72 -0.68 7.27e-46 Breast cancer; CRC cis rs1005277 0.579 rs2505257 chr10:38372664 A/G cg00409905 chr10:38381863 ZNF37A -0.67 -11.04 -0.52 2.56e-24 Extrinsic epigenetic age acceleration; CRC trans rs6703335 0.870 rs10803142 chr1:243598234 A/G cg26851410 chr19:2785307 THOP1 0.43 6.05 0.32 4.04e-9 Schizophrenia;Schizophrenia, schizoaffective disorder or bipolar disorder; CRC cis rs477895 0.653 rs11601577 chr11:63928574 C/T cg04317338 chr11:64019027 PLCB3 0.58 7.18 0.37 4.57e-12 Mean platelet volume; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg12593303 chr2:54785406 SPTBN1 0.46 6.53 0.34 2.42e-10 Response to antipsychotic treatment; CRC cis rs2745967 0.715 rs2796254 chr1:208069137 G/A cg09788693 chr1:208063733 CD34 0.45 6.78 0.35 5.44e-11 Resting heart rate; CRC trans rs1973993 0.691 rs1989141 chr1:96898520 C/T cg10631902 chr5:14652156 NA 0.62 12.35 0.56 4.76e-29 Weight; CRC cis rs970548 1.000 rs12257549 chr10:46029631 C/T cg15590007 chr10:45870220 ALOX5 0.47 5.91 0.31 8.38e-9 Total cholesterol levels;Cholesterol, total;HDL cholesterol;HDL cholesterol levels; CRC cis rs9467773 0.595 rs13207371 chr6:26591074 G/A cg09904177 chr6:26538194 HMGN4 0.63 9.23 0.45 3.31e-18 Intelligence (multi-trait analysis); CRC cis rs4766646 0.619 rs7304559 chr12:110289501 T/G cg01252219 chr12:110302105 GLTP 0.4 6.08 0.32 3.38e-9 Metabolite levels (MHPG); CRC cis rs736408 0.608 rs4687657 chr3:52852538 G/T cg15147215 chr3:52552868 STAB1 -0.42 -5.94 -0.31 7.43e-9 Bipolar disorder; CRC cis rs4713118 0.911 rs9461406 chr6:27719764 C/T cg02683197 chr6:28174875 NA -0.62 -7.45 -0.38 8.28e-13 Parkinson's disease; CRC cis rs12024301 0.557 rs12048127 chr1:183610804 A/G cg11505048 chr1:183622726 RGL1;APOBEC4 0.81 7.0 0.36 1.42e-11 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs10870270 1.000 rs4880250 chr10:133773919 G/A cg17892150 chr10:133769511 PPP2R2D -0.74 -10.97 -0.52 4.45e-24 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; CRC trans rs2303319 0.504 rs62189047 chr2:162613314 T/A cg03774468 chr3:140950104 ACPL2 -0.65 -6.07 -0.32 3.61e-9 Cognitive function; CRC cis rs524281 0.861 rs7943911 chr11:65943054 G/A cg16950941 chr11:66035639 RAB1B -0.6 -7.43 -0.38 9.29e-13 Electroencephalogram traits; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg03114442 chr13:52378179 DHRS12 0.45 6.15 0.32 2.19e-9 Anxiety disorder; CRC cis rs7512552 0.839 rs1260421 chr1:150357780 G/A cg15654264 chr1:150340011 RPRD2 0.6 8.44 0.42 1.02e-15 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); CRC cis rs1997103 1.000 rs9642578 chr7:55400320 A/G cg17469321 chr7:55412551 NA 0.7 10.9 0.52 8.12e-24 QRS interval (sulfonylurea treatment interaction); CRC trans rs7726839 0.540 rs57306627 chr5:597643 T/C cg25482853 chr8:67687455 SGK3 1.06 12.52 0.57 1.15e-29 Obesity-related traits; CRC cis rs4642101 0.694 rs12631514 chr3:12838293 G/C cg24848339 chr3:12840334 CAND2 0.31 5.8 0.3 1.6e-8 QRS complex (12-leadsum); CRC cis rs992157 0.835 rs4674283 chr2:219144254 G/A cg00012203 chr2:219082015 ARPC2 -0.47 -7.16 -0.37 5.15e-12 Colorectal cancer; CRC cis rs2692947 0.711 rs34639392 chr2:96508976 T/C cg23100626 chr2:96804247 ASTL 0.27 7.07 0.36 9.2e-12 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; CRC cis rs25645 0.502 rs7207600 chr17:38091660 G/A cg26162295 chr17:38119207 GSDMA -0.35 -5.91 -0.31 8.71e-9 Myeloid white cell count; CRC cis rs9522267 0.535 rs9522301 chr13:112236726 A/T cg10483660 chr13:112241077 NA -0.47 -8.92 -0.44 3.28e-17 Hepatitis; CRC cis rs62432291 0.681 rs431205 chr6:159662499 A/G cg14500486 chr6:159655392 FNDC1 -0.76 -10.24 -0.49 1.53e-21 Joint mobility (Beighton score); CRC trans rs1814175 0.645 rs1721997 chr11:49916653 T/C cg15704280 chr7:45808275 SEPT13 -0.95 -16.82 -0.68 3.11e-46 Height; CRC cis rs7771547 0.519 rs2057351 chr6:36361682 G/A cg04289385 chr6:36355825 ETV7 0.45 5.65 0.3 3.56e-8 Platelet distribution width; CRC cis rs7826238 0.566 rs2945886 chr8:8148270 C/G cg06636001 chr8:8085503 FLJ10661 0.66 10.45 0.5 2.82e-22 Systolic blood pressure; CRC cis rs3617 0.573 rs62253583 chr3:52928334 G/A cg11645453 chr3:52864694 ITIH4 -0.42 -8.07 -0.41 1.32e-14 Red blood cell count;Autism spectrum disorder or schizophrenia; CRC cis rs35264875 0.851 rs72930621 chr11:68866745 C/T cg03469862 chr11:68924853 NA 0.46 6.14 0.32 2.33e-9 Blond vs. brown hair color; CRC cis rs11758351 0.660 rs11753131 chr6:26219384 G/A cg08260959 chr6:26240920 HIST1H4F -0.35 -5.6 -0.3 4.44e-8 Gout;Renal underexcretion gout; CRC cis rs7178572 0.568 rs8030074 chr15:77654232 C/T cg22256960 chr15:77711686 NA -0.64 -9.4 -0.46 9.62e-19 Type 2 diabetes; CRC trans rs208520 0.507 rs7755710 chr6:66783355 G/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.14 -24.6 -0.8 1.51e-76 Exhaled nitric oxide output; CRC cis rs9311474 0.508 rs11720159 chr3:52617802 T/G cg05573699 chr3:52720067 GNL3;PBRM1 -0.47 -6.91 -0.36 2.47e-11 Electroencephalogram traits; CRC cis rs539096 0.501 rs713191 chr1:44314553 A/G cg13606994 chr1:44402422 ARTN -0.33 -5.61 -0.3 4.2e-8 Intelligence (multi-trait analysis); CRC cis rs6545883 0.524 rs7561697 chr2:61519165 G/C cg10580144 chr2:61372316 C2orf74 -0.35 -7.69 -0.39 1.73e-13 Tuberculosis; CRC trans rs2840044 1.000 rs1671656 chr17:33939661 C/T cg19694781 chr19:47549865 TMEM160 -0.45 -7.09 -0.36 8.13e-12 Response to radiotherapy in cancer (late toxicity); CRC cis rs597539 0.652 rs553875 chr11:68695144 T/G cg06112835 chr11:68658793 MRPL21 0.43 6.76 0.35 6.23e-11 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs1552244 1.000 rs68067759 chr3:10150535 T/C cg08888203 chr3:10149979 C3orf24 0.71 9.72 0.47 8.73e-20 Alzheimer's disease; CRC trans rs7267979 1.000 rs2257432 chr20:25271086 T/C cg17903999 chr18:56338584 MALT1 -0.41 -6.92 -0.36 2.32e-11 Liver enzyme levels (alkaline phosphatase); CRC trans rs1814175 0.712 rs9665784 chr11:50030617 C/T cg11707556 chr5:10655725 ANKRD33B -0.43 -8.37 -0.42 1.72e-15 Height; CRC cis rs875971 0.964 rs6945032 chr7:65922486 C/T cg18876405 chr7:65276391 NA 0.52 8.85 0.44 5.32e-17 Aortic root size; CRC cis rs1707322 0.721 rs12049027 chr1:46118184 A/T cg03146154 chr1:46216737 IPP 0.67 9.74 0.47 7.45e-20 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs4566357 0.615 rs12618793 chr2:227909552 T/C cg11843606 chr2:227700838 RHBDD1 -0.44 -6.79 -0.35 5.09e-11 Coronary artery disease; CRC cis rs2032447 0.869 rs2230655 chr6:26033506 A/G cg26028573 chr6:26043587 HIST1H2BB -0.51 -7.58 -0.39 3.52e-13 Intelligence (multi-trait analysis); CRC cis rs67311347 1.000 rs1047855 chr3:40468896 A/G cg09455208 chr3:40491958 NA -0.52 -9.81 -0.48 4.19e-20 Renal cell carcinoma; CRC trans rs12639288 0.962 rs12638639 chr3:167660757 C/T cg02570054 chr12:49717017 TROAP -0.54 -6.19 -0.32 1.77e-9 Hirschsprung disease; CRC cis rs17401966 1.000 rs12402052 chr1:10318652 C/G cg19773385 chr1:10388646 KIF1B -0.58 -8.04 -0.41 1.58e-14 Hepatocellular carcinoma; CRC trans rs7615952 0.576 rs2276727 chr3:125826243 C/T cg07211511 chr3:129823064 LOC729375 -0.66 -8.87 -0.44 4.61e-17 Blood pressure (smoking interaction); CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg14272175 chr3:58318960 PXK -0.42 -6.22 -0.32 1.53e-9 Myopia (pathological); CRC cis rs644799 0.601 rs7902 chr11:95565288 A/G cg25478527 chr11:95522999 CEP57;FAM76B 0.41 6.2 0.32 1.74e-9 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs6582630 0.502 rs1607867 chr12:38385463 C/T cg13010199 chr12:38710504 ALG10B 0.47 6.3 0.33 9.3e-10 Drug-induced liver injury (flucloxacillin); CRC cis rs7772486 0.597 rs2485631 chr6:146190077 G/C cg13319975 chr6:146136371 FBXO30 -0.64 -9.23 -0.45 3.5e-18 Lobe attachment (rater-scored or self-reported); CRC cis rs9322817 0.691 rs9391249 chr6:105343433 T/A cg02098413 chr6:105308735 HACE1 0.46 9.14 0.45 6.64e-18 Thyroid stimulating hormone; CRC cis rs62408225 1.000 rs62408233 chr6:90976609 G/A cg06866423 chr6:90926672 BACH2 0.5 8.15 0.41 7.56e-15 Eosinophil counts;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC cis rs1728785 0.901 rs698715 chr16:68560896 A/G cg02972257 chr16:68554789 NA -0.62 -7.08 -0.36 8.68e-12 Ulcerative colitis; CRC cis rs17818399 0.653 rs34050156 chr2:46777646 A/G cg26688816 chr2:46740690 ATP6V1E2 -0.46 -5.97 -0.31 6.01e-9 Height; CRC trans rs8123881 0.733 rs7268466 chr20:15810676 C/T cg20011051 chr10:105881722 C10orf78 0.61 6.42 0.33 4.67e-10 Body mass index; CRC cis rs7726839 0.574 rs12517345 chr5:628294 G/A cg14541582 chr5:601475 NA -0.36 -7.3 -0.37 2.21e-12 Obesity-related traits; CRC cis rs17152411 0.895 rs7080475 chr10:126585767 A/G cg07906193 chr10:126599966 NA 0.56 6.33 0.33 7.97e-10 Height; CRC cis rs7666738 1.000 rs13124102 chr4:98990696 G/A cg03676636 chr4:99064102 C4orf37 0.23 6.32 0.33 8.37e-10 Colonoscopy-negative controls vs population controls; CRC cis rs9649465 0.561 rs600420 chr7:123408050 G/A cg03229431 chr7:123269106 ASB15 0.57 9.29 0.46 2.21e-18 Migraine; CRC cis rs995000 0.899 rs10889356 chr1:63155349 G/A cg19896129 chr1:63156450 NA 0.41 5.96 0.31 6.67e-9 Triglyceride levels; CRC trans rs3780486 1.000 rs10813957 chr9:33153527 G/T cg20290983 chr6:43655470 MRPS18A 1.04 17.05 0.68 3.79e-47 IgG glycosylation; CRC cis rs7412746 0.658 rs7526489 chr1:150726238 C/T cg10589385 chr1:150898437 SETDB1 0.32 6.51 0.34 2.73e-10 Melanoma; CRC cis rs4731207 0.596 rs12113770 chr7:124589740 G/A cg23710748 chr7:124431027 NA -0.38 -6.08 -0.32 3.35e-9 Cutaneous malignant melanoma; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg21790971 chr4:54244117 FIP1L1 0.56 7.38 0.38 1.34e-12 Thyroid stimulating hormone; CRC cis rs6582630 0.537 rs1949611 chr12:38373092 C/T cg26384229 chr12:38710491 ALG10B -0.65 -9.86 -0.48 2.87e-20 Drug-induced liver injury (flucloxacillin); CRC cis rs4073582 0.595 rs708472 chr11:65930990 A/G cg16950941 chr11:66035639 RAB1B 0.71 12.29 0.56 8.27e-29 Gout; CRC cis rs847577 0.569 rs7804318 chr7:97796635 A/G cg24562669 chr7:97807699 LMTK2 -0.77 -16.88 -0.68 1.72e-46 Breast cancer; CRC cis rs6835098 0.962 rs4377567 chr4:174083590 C/G cg08422745 chr4:174089978 GALNT7 0.94 15.83 0.66 2.25e-42 Dementia and core Alzheimer's disease neuropathologic changes; CRC cis rs6582630 0.502 rs11182760 chr12:38606273 A/T cg13010199 chr12:38710504 ALG10B 0.45 5.7 0.3 2.72e-8 Drug-induced liver injury (flucloxacillin); CRC cis rs172166 0.561 rs149971 chr6:27982152 G/A cg15845792 chr6:28175446 NA 0.63 9.35 0.46 1.43e-18 Cardiac Troponin-T levels; CRC cis rs13096480 0.583 rs17598137 chr3:49891362 G/T cg00706505 chr3:49142215 QARS 0.41 5.91 0.31 8.76e-9 Intelligence (multi-trait analysis); CRC cis rs9420 0.925 rs78587207 chr11:57654991 T/G cg23127183 chr11:57508653 C11orf31 -0.52 -6.83 -0.35 4.17e-11 Schizophrenia; CRC cis rs4509693 0.722 rs10883536 chr10:102489331 A/C cg23167259 chr10:102495509 NA -0.43 -5.68 -0.3 3.02e-8 Alzheimer's disease; CRC cis rs601339 1.000 rs525215 chr12:123179771 G/A cg25190513 chr12:123201362 GPR109B -0.49 -6.27 -0.33 1.11e-9 Adiponectin levels; CRC trans rs875971 0.660 rs2191268 chr7:66110224 C/T cg25937854 chr12:120150414 CIT 0.35 5.96 0.31 6.53e-9 Aortic root size; CRC cis rs8060686 0.920 rs3809630 chr16:67879400 G/A cg19582491 chr16:67682965 RLTPR -0.56 -6.8 -0.35 4.8e-11 HDL cholesterol;Metabolic syndrome; CRC cis rs12545109 0.879 rs2670015 chr8:57376607 T/A cg09654669 chr8:57350985 NA -0.44 -5.86 -0.31 1.12e-8 Obesity-related traits; CRC cis rs9908102 0.740 rs4792311 chr17:12915009 A/G cg26162695 chr17:12921313 ELAC2 -0.45 -6.04 -0.32 4.25e-9 Schizophrenia; CRC cis rs9325144 0.555 rs1825806 chr12:38692547 G/A cg13010199 chr12:38710504 ALG10B 0.44 6.31 0.33 8.89e-10 Morning vs. evening chronotype; CRC cis rs10986311 0.775 rs1984001 chr9:127137801 T/C cg14243010 chr9:127117328 LOC100129034;PSMB7 0.43 6.45 0.33 4.07e-10 Vitiligo; CRC cis rs801193 0.569 rs2659892 chr7:66200305 A/G cg00343986 chr7:65444356 GUSB 0.44 6.15 0.32 2.21e-9 Aortic root size; CRC cis rs597539 0.652 rs579136 chr11:68637476 C/G cg06112835 chr11:68658793 MRPL21 0.43 6.88 0.35 3.11e-11 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs55665837 1.000 rs12288873 chr11:14450465 C/T cg19336497 chr11:14380999 RRAS2 -0.39 -6.64 -0.34 1.3100000000000001e-10 Vitamin D levels; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg11617147 chr7:105517689 ATXN7L1 0.38 6.01 0.31 4.87e-9 Response to antipsychotic treatment; CRC cis rs7666738 0.830 rs2865980 chr4:99027422 T/G cg05340658 chr4:99064831 C4orf37 0.6 9.26 0.45 2.78e-18 Colonoscopy-negative controls vs population controls; CRC cis rs1552244 1.000 rs12374115 chr3:10134766 A/G cg10729496 chr3:10149963 C3orf24 -0.51 -6.74 -0.35 7.29e-11 Alzheimer's disease; CRC cis rs2281845 0.965 rs3738262 chr1:201083343 A/G cg24849736 chr1:201084428 NA 0.65 12.36 0.56 4.37e-29 Permanent tooth development; CRC cis rs7512552 0.839 rs1260405 chr1:150304781 A/G cg15654264 chr1:150340011 RPRD2 0.58 8.3 0.42 2.8e-15 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); CRC cis rs6088580 0.634 rs1890002 chr20:32919219 A/G cg24642439 chr20:33292090 TP53INP2 -0.41 -6.89 -0.36 2.79e-11 Glomerular filtration rate (creatinine); CRC cis rs12692738 0.526 rs355857 chr2:165629214 A/G cg03182029 chr2:165697222 COBLL1 0.5 5.86 0.31 1.11e-8 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);Waist-to-hip ratio adjusted for BMI in non-smokers;Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction);Waist-to-hip ratio adjusted for body mass index; CRC cis rs7927771 0.524 rs10838774 chr11:47856114 A/G cg20307385 chr11:47447363 PSMC3 0.46 6.58 0.34 1.91e-10 Subjective well-being; CRC cis rs780096 0.546 rs6547626 chr2:27646770 C/T cg12000995 chr2:27665139 KRTCAP3 -0.31 -6.48 -0.34 3.31e-10 Total body bone mineral density; CRC cis rs7584330 0.740 rs11896232 chr2:238438124 T/C cg16989719 chr2:238392110 NA -0.38 -7.57 -0.38 3.88e-13 Prostate cancer; CRC trans rs11098499 0.954 rs10017543 chr4:120321420 G/A cg25214090 chr10:38739885 LOC399744 0.65 10.3 0.49 9.79e-22 Corneal astigmatism; CRC cis rs12760731 0.920 rs61109337 chr1:178484674 A/G cg00404053 chr1:178313656 RASAL2 0.72 8.02 0.4 1.89e-14 Obesity-related traits; CRC cis rs1519814 1.000 rs7000609 chr8:121106264 C/T cg22335954 chr8:121166405 COL14A1 0.57 7.19 0.37 4.26e-12 Breast cancer; CRC cis rs35883536 1.000 rs2491822 chr1:101115839 T/C cg14515779 chr1:101123966 NA 0.38 7.03 0.36 1.21e-11 Monocyte count; CRC cis rs9969804 0.747 rs7021624 chr9:95531220 C/G cg14631576 chr9:95140430 CENPP -0.31 -5.73 -0.3 2.23e-8 Height; CRC cis rs6121246 0.865 rs6058421 chr20:30295013 G/C cg13852791 chr20:30311386 BCL2L1 0.69 11.08 0.52 1.79e-24 Mean corpuscular hemoglobin; CRC cis rs9322193 0.923 rs9688517 chr6:150061791 T/C cg00933542 chr6:150070202 PCMT1 0.34 6.97 0.36 1.74e-11 Lung cancer; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg00415263 chr7:26331488 SNX10 0.43 5.97 0.31 6.27e-9 Anxiety disorder; CRC cis rs17376456 0.932 rs3940842 chr5:93534858 C/A cg25358565 chr5:93447407 FAM172A 1.07 9.87 0.48 2.78e-20 Diabetic retinopathy; CRC cis rs11785400 1.000 rs4484678 chr8:143730796 A/G cg24634471 chr8:143751801 JRK 0.53 7.55 0.38 4.26e-13 Schizophrenia; CRC cis rs4853012 0.838 rs60705299 chr2:74345370 C/G cg20891558 chr2:74357851 NA 0.59 9.45 0.46 6.64e-19 Gestational age at birth (maternal effect); CRC cis rs10946940 0.965 rs6910838 chr6:27515519 A/C cg15845792 chr6:28175446 NA -0.47 -6.39 -0.33 5.73e-10 Systemic lupus erythematosus; CRC trans rs875971 0.660 rs2191268 chr7:66110224 C/T cg00323100 chr4:40059856 N4BP2;LOC344967 -0.43 -6.74 -0.35 7.3e-11 Aortic root size; CRC cis rs7666738 0.830 rs6532701 chr4:98745134 C/T cg17366294 chr4:99064904 C4orf37 0.43 7.06 0.36 9.75e-12 Colonoscopy-negative controls vs population controls; CRC cis rs12602172 1 rs12602172 chr17:38163567 G/A cg17467752 chr17:38218738 THRA 0.73 12.0 0.55 9.38e-28 Neutrophil percentage of white cells;Granulocyte percentage of myeloid white cells; CRC cis rs1163251 0.837 rs595283 chr1:120247887 C/G cg19096424 chr1:120255104 PHGDH -0.4 -5.64 -0.3 3.72e-8 Blood metabolite levels; CRC cis rs6747952 0.899 rs2121404 chr2:239083826 A/G cg07480446 chr2:239069576 NA -0.37 -6.98 -0.36 1.68e-11 Mean corpuscular hemoglobin concentration; CRC cis rs17270561 0.723 rs12213243 chr6:25890108 C/T cg17691542 chr6:26056736 HIST1H1C 0.78 10.04 0.48 7.01e-21 Iron status biomarkers; CRC cis rs644799 0.648 rs1016031 chr11:95473365 C/T cg25622487 chr11:95524042 FAM76B;CEP57 -0.45 -6.26 -0.33 1.18e-9 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs977987 0.843 rs8056080 chr16:75410798 C/A cg03315344 chr16:75512273 CHST6 0.5 8.55 0.43 4.83e-16 Dupuytren's disease; CRC cis rs10484885 0.824 rs11967579 chr6:90540008 G/T cg13799429 chr6:90582589 CASP8AP2 -0.73 -7.93 -0.4 3.52e-14 QRS interval (sulfonylurea treatment interaction); CRC cis rs28386778 0.933 rs2665804 chr17:61951836 G/T cg06873352 chr17:61820015 STRADA 0.75 14.04 0.61 2.11e-35 Prudent dietary pattern; CRC cis rs2239547 0.657 rs13072536 chr3:52861211 A/T cg18404041 chr3:52824283 ITIH1 -0.41 -7.65 -0.39 2.25e-13 Schizophrenia; CRC cis rs597539 0.690 rs608810 chr11:68624118 G/C cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.85 13.64 0.6 6.82e-34 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs56235845 0.964 rs4075958 chr5:176784512 A/G cg05207973 chr5:176823642 SLC34A1 -0.49 -7.48 -0.38 6.86e-13 Hemoglobin concentration;Hematocrit; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg06102777 chr11:63382095 PLA2G16 -0.41 -6.39 -0.33 5.55e-10 Liver disease severity in Alagille syndrome; CRC cis rs6570726 0.693 rs450921 chr6:145864260 C/T cg05347473 chr6:146136440 FBXO30 0.39 5.95 0.31 6.94e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs12497850 0.931 rs10780033 chr3:48891275 T/C cg07636037 chr3:49044803 WDR6 1.04 18.72 0.72 9.87e-54 Parkinson's disease; CRC cis rs853679 0.824 rs1321505 chr6:28052823 A/C cg15845792 chr6:28175446 NA 0.77 6.27 0.33 1.12e-9 Depression; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg17362109 chr3:194981274 C3orf21 0.46 6.16 0.32 2.11e-9 Thyroid stimulating hormone; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg05526438 chr5:174350112 NA -0.39 -6.48 -0.34 3.27e-10 Liver disease severity in Alagille syndrome; CRC cis rs1448094 0.511 rs61930579 chr12:86157044 G/A cg00310523 chr12:86230176 RASSF9 0.41 6.62 0.34 1.5e-10 Major depressive disorder; CRC cis rs6088813 1.000 rs2248393 chr20:33926103 C/G cg14752227 chr20:34000481 UQCC 0.37 5.82 0.31 1.42e-8 Height; CRC cis rs3087591 0.708 rs2854311 chr17:29671327 C/T cg24425628 chr17:29625626 OMG;NF1 0.68 12.62 0.57 4.88e-30 Hip circumference; CRC cis rs9322193 0.923 rs9800686 chr6:149955600 A/C cg13206674 chr6:150067644 NUP43 0.66 9.53 0.47 3.49e-19 Lung cancer; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg07639963 chr12:77157760 ZDHHC17 0.39 5.99 0.31 5.64e-9 Liver disease severity in Alagille syndrome; CRC cis rs9902453 0.808 rs1986555 chr17:28014448 T/A cg26525008 chr17:28256777 EFCAB5;SSH2 0.6 8.99 0.44 1.98e-17 Coffee consumption (cups per day); CRC cis rs13191362 0.507 rs2803051 chr6:163034979 G/A cg21926612 chr6:163149169 PACRG;PARK2 -0.61 -9.64 -0.47 1.56e-19 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs7618915 0.547 rs11130311 chr3:52675005 T/C cg11645453 chr3:52864694 ITIH4 0.36 6.25 0.33 1.29e-9 Bipolar disorder; CRC cis rs4718428 0.705 rs62465692 chr7:66295745 T/C cg18252515 chr7:66147081 NA -0.54 -7.48 -0.38 6.94e-13 Corneal structure; CRC cis rs6662572 0.737 rs4434876 chr1:46270129 T/C cg08644498 chr1:46502608 NA -0.44 -7.0 -0.36 1.44e-11 Blood protein levels; CRC cis rs425277 0.585 rs2222217 chr1:2063164 G/A cg21194808 chr1:2205498 SKI -0.39 -5.66 -0.3 3.3e-8 Height; CRC cis rs6860806 0.507 rs270606 chr5:131650867 A/G cg07395648 chr5:131743802 NA -0.42 -5.78 -0.3 1.72e-8 Breast cancer; CRC trans rs1005277 0.579 rs1614236 chr10:38502996 C/T cg27523141 chr10:43048294 ZNF37B 0.45 6.47 0.34 3.65e-10 Extrinsic epigenetic age acceleration; CRC cis rs561341 0.831 rs11658469 chr17:30206426 T/C cg19193384 chr17:30244184 NA 0.46 5.7 0.3 2.62e-8 Hip circumference adjusted for BMI; CRC cis rs877282 0.898 rs11253346 chr10:765313 A/G cg17470449 chr10:769945 NA 0.64 8.08 0.41 1.28e-14 Uric acid levels; CRC cis rs7772486 0.875 rs9399572 chr6:146362945 T/G cg05347473 chr6:146136440 FBXO30 0.37 5.89 0.31 9.38e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs4713118 0.662 rs9468271 chr6:28024570 A/G cg15786705 chr6:28176104 NA 0.7 9.41 0.46 9.04e-19 Parkinson's disease; CRC cis rs17125944 0.686 rs77650471 chr14:53364307 C/T cg00686598 chr14:53173677 PSMC6 0.87 7.47 0.38 7.52e-13 Alzheimer's disease (late onset); CRC cis rs10504229 0.593 rs77607045 chr8:58010464 T/C cg08219700 chr8:58056026 NA 0.55 6.5 0.34 2.99e-10 Developmental language disorder (linguistic errors); CRC cis rs7107770 1.000 rs4935912 chr11:125090279 T/G cg27629782 chr11:125073726 PKNOX2 0.47 5.86 0.31 1.11e-8 Photic sneeze reflex; CRC cis rs45509595 0.841 rs401754 chr6:27782538 T/A cg15845792 chr6:28175446 NA 0.72 6.15 0.32 2.24e-9 Breast cancer; CRC cis rs644799 0.965 rs545342 chr11:95545369 T/C cg25622487 chr11:95524042 FAM76B;CEP57 0.76 11.87 0.55 2.62e-27 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs57221529 0.608 rs11749927 chr5:668842 C/T cg09021430 chr5:549028 NA -0.53 -6.46 -0.34 3.74e-10 Lung disease severity in cystic fibrosis; CRC cis rs5750830 0.597 rs4821889 chr22:39777254 T/C cg05872129 chr22:39784769 NA -0.61 -11.48 -0.53 6.9e-26 Intelligence (multi-trait analysis); CRC trans rs7937682 0.889 rs564086 chr11:111501079 C/G cg18187862 chr3:45730750 SACM1L 0.48 6.88 0.35 3.06e-11 Primary sclerosing cholangitis; CRC cis rs910316 1.000 rs12889309 chr14:75593902 C/T cg08847533 chr14:75593920 NEK9 0.95 18.41 0.71 1.56e-52 Height; CRC cis rs9399135 0.967 rs4895434 chr6:135293365 G/A cg24558204 chr6:135376177 HBS1L 0.47 7.2 0.37 4e-12 Red blood cell count; CRC cis rs9326248 1.000 rs10790175 chr11:117034729 A/G cg11861562 chr11:117069780 TAGLN 0.39 8.99 0.44 2e-17 Blood protein levels; CRC cis rs7904985 1.000 rs7904985 chr10:88116479 A/G cg07322936 chr10:88137208 NA 0.46 6.11 0.32 2.84e-9 Barrett's esophagus; CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg25750404 chr12:6579648 VAMP1 -0.58 -7.15 -0.37 5.5e-12 Diisocyanate-induced asthma; CRC cis rs4819052 0.765 rs2838854 chr21:46680364 A/G cg02159808 chr21:46707872 POFUT2;LOC642852 0.53 7.01 0.36 1.39e-11 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs4664293 1.000 rs13014418 chr2:160483685 T/G cg08347373 chr2:160653686 CD302 -0.44 -7.25 -0.37 2.97e-12 Monocyte percentage of white cells; CRC trans rs1346081 0.786 rs1425645 chr4:68028175 C/T cg12069248 chr11:65628378 MUS81 0.5 5.96 0.31 6.53e-9 Intelligence (multi-trait analysis); CRC cis rs9916302 0.904 rs6503519 chr17:37706578 A/G cg00129232 chr17:37814104 STARD3 -0.56 -8.43 -0.42 1.06e-15 Glomerular filtration rate (creatinine); CRC cis rs227584 0.663 rs3180912 chr17:42259463 A/G cg16434002 chr17:42200994 HDAC5 -0.43 -6.25 -0.33 1.28e-9 Bone mineral density (hip);Bone mineral density; CRC cis rs12745968 0.653 rs4847301 chr1:93200924 A/G cg17283838 chr1:93427260 FAM69A -0.44 -5.99 -0.31 5.4e-9 Bipolar disorder and schizophrenia; CRC cis rs11971779 0.616 rs11771715 chr7:139027496 T/C cg23387468 chr7:139079360 LUC7L2 0.4 7.13 0.37 6.58e-12 Diisocyanate-induced asthma; CRC cis rs863345 0.604 rs6664542 chr1:158462431 G/T cg12129480 chr1:158549410 OR10X1 -0.29 -6.04 -0.32 4.2e-9 Pneumococcal bacteremia; CRC cis rs9443645 0.901 rs9343843 chr6:79585625 C/T cg11833968 chr6:79620685 NA -0.37 -6.47 -0.34 3.53e-10 Intelligence (multi-trait analysis); CRC cis rs4746818 0.892 rs2394505 chr10:70871598 A/G cg11621586 chr10:70884670 VPS26A -0.61 -6.48 -0.34 3.38e-10 Left atrial antero-posterior diameter; CRC cis rs17376456 0.877 rs10060462 chr5:93455073 C/T cg21475434 chr5:93447410 FAM172A 0.75 7.65 0.39 2.18e-13 Diabetic retinopathy; CRC cis rs597539 0.690 rs608810 chr11:68624118 G/C cg21963583 chr11:68658836 MRPL21 0.6 10.36 0.5 6.12e-22 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs12497850 0.866 rs6791234 chr3:48996137 A/G cg20833759 chr3:49053208 WDR6;DALRD3 0.53 9.26 0.45 2.62e-18 Parkinson's disease; CRC cis rs9322193 0.887 rs3734295 chr6:149915053 C/T cg00933542 chr6:150070202 PCMT1 0.33 6.65 0.34 1.21e-10 Lung cancer; CRC cis rs2075371 1.000 rs7486 chr7:133975183 A/G cg02659138 chr7:134003124 SLC35B4 0.36 6.22 0.32 1.5e-9 Mean platelet volume; CRC cis rs910316 0.967 rs10246 chr14:75544470 T/A cg08847533 chr14:75593920 NEK9 0.93 17.81 0.7 3.75e-50 Height; CRC cis rs1799949 0.965 rs9897425 chr17:41430179 C/G cg23758822 chr17:41437982 NA 0.84 15.48 0.65 5.52e-41 Menopause (age at onset); CRC cis rs2243480 1.000 rs316331 chr7:65604622 A/G cg18252515 chr7:66147081 NA 1.18 13.92 0.61 5.82e-35 Diabetic kidney disease; CRC cis rs57024841 0.562 rs2071006 chr9:139839904 G/T cg00693599 chr9:139836323 FBXW5 -0.45 -7.43 -0.38 9.29e-13 Beta-trace protein levels; CRC cis rs4713118 0.869 rs9393851 chr6:27699581 A/T cg21251018 chr6:28226885 NKAPL 0.38 5.71 0.3 2.5e-8 Parkinson's disease; CRC cis rs9987353 0.522 rs2929466 chr8:9063899 G/T cg06636001 chr8:8085503 FLJ10661 -0.43 -6.58 -0.34 1.91e-10 Recombination measurement; CRC cis rs270601 0.770 rs1007602 chr5:131602166 T/C cg27615366 chr5:131592974 PDLIM4 0.34 6.46 0.34 3.73e-10 Acylcarnitine levels; CRC cis rs6540559 0.673 rs17015224 chr1:209968918 G/A cg25204440 chr1:209979598 IRF6 0.49 5.92 0.31 8.1e-9 Cleft lip with or without cleft palate; CRC cis rs9291683 0.588 rs11732054 chr4:9999877 C/T cg11266682 chr4:10021025 SLC2A9 0.54 11.45 0.53 8.7e-26 Bone mineral density; CRC cis rs11785400 1.000 rs4736342 chr8:143735190 A/G cg10596483 chr8:143751796 JRK 0.46 6.38 0.33 6.11e-10 Schizophrenia; CRC cis rs12130219 0.500 rs4845737 chr1:152177539 G/A cg26879891 chr1:152191343 HRNR -0.31 -5.89 -0.31 9.8e-9 Inflammatory skin disease; CRC cis rs8180040 1.000 rs807931 chr3:47389317 C/T cg27129171 chr3:47204927 SETD2 0.64 10.52 0.5 1.65e-22 Colorectal cancer; CRC cis rs2880765 0.835 rs4344688 chr15:86043007 A/C cg17133734 chr15:86042851 AKAP13 0.42 6.76 0.35 6.22e-11 Coronary artery disease; CRC cis rs300703 0.542 rs415660 chr2:189972 C/T cg21211680 chr2:198530 NA 0.72 9.17 0.45 5.35e-18 Blood protein levels; CRC cis rs3858526 0.883 rs10769320 chr11:5932831 G/C cg02574844 chr11:5959923 NA -0.4 -5.61 -0.3 4.38e-8 DNA methylation (variation); CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg13789711 chr9:139743225 PHPT1 -0.52 -6.24 -0.33 1.33e-9 Diisocyanate-induced asthma; CRC cis rs7666738 0.761 rs28758886 chr4:99059704 C/T cg05340658 chr4:99064831 C4orf37 0.6 9.25 0.45 2.97e-18 Colonoscopy-negative controls vs population controls; CRC cis rs67311347 1.000 rs9829800 chr3:40443927 T/C cg24209194 chr3:40518798 ZNF619 0.42 6.35 0.33 7.22e-10 Renal cell carcinoma; CRC cis rs7811142 0.830 rs11765869 chr7:99964789 T/G cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.71 9.12 0.45 7.72e-18 Platelet count; CRC cis rs6931421 1.000 rs6931421 chr6:80880138 A/C cg08355045 chr6:80787529 NA 0.47 7.49 0.38 6.5e-13 Sitting height ratio; CRC cis rs2952156 0.883 rs8077172 chr17:37834977 G/T cg00129232 chr17:37814104 STARD3 -0.68 -12.01 -0.55 8.36e-28 Asthma; CRC cis rs10504229 0.654 rs903705 chr8:58128185 T/A cg22535103 chr8:58192502 C8orf71 -0.7 -9.34 -0.46 1.47e-18 Developmental language disorder (linguistic errors); CRC cis rs4731207 0.596 rs12535807 chr7:124591433 A/T cg23710748 chr7:124431027 NA -0.38 -6.12 -0.32 2.61e-9 Cutaneous malignant melanoma; CRC cis rs57221529 0.766 rs12521051 chr5:560440 A/G cg17948913 chr5:572064 NA -0.54 -6.28 -0.33 1.06e-9 Lung disease severity in cystic fibrosis; CRC cis rs2032447 0.670 rs198815 chr6:26127271 A/G cg18357526 chr6:26021779 HIST1H4A -0.7 -10.35 -0.5 6.42e-22 Intelligence (multi-trait analysis); CRC cis rs6840360 1.000 rs751014 chr4:152601902 G/A cg09659197 chr4:152720779 NA 0.52 11.13 0.52 1.23e-24 Intelligence (multi-trait analysis); CRC trans rs12495832 0.778 rs80192600 chr3:147910628 G/T cg10221266 chr7:153579447 NA 0.56 6.13 0.32 2.54e-9 Chin dimples; CRC cis rs2239547 0.562 rs2581810 chr3:52960859 C/T cg18404041 chr3:52824283 ITIH1 0.33 6.51 0.34 2.86e-10 Schizophrenia; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg15926737 chr12:57853737 GLI1 0.5 6.58 0.34 1.88e-10 Thyroid stimulating hormone; CRC cis rs4713118 0.868 rs760587 chr6:27740300 C/A cg12172441 chr6:28176163 NA 0.6 6.59 0.34 1.71e-10 Parkinson's disease; CRC cis rs875971 0.543 rs801191 chr7:66032955 G/A cg00343986 chr7:65444356 GUSB -0.47 -6.99 -0.36 1.52e-11 Aortic root size; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg23606286 chr1:145470592 ANKRD34A;POLR3GL -0.41 -5.99 -0.31 5.39e-9 Myopia (pathological); CRC cis rs7937682 0.924 rs499750 chr11:111513645 T/G cg09085632 chr11:111637200 PPP2R1B -1.02 -20.11 -0.74 3.17e-59 Primary sclerosing cholangitis; CRC cis rs13118159 0.778 rs12640984 chr4:1338834 G/A cg21620606 chr4:1342894 KIAA1530 0.4 6.97 0.36 1.74e-11 Longevity; CRC cis rs2530545 0.619 rs6975964 chr7:34662452 T/G cg14401837 chr7:34697493 NPSR1 0.42 6.27 0.33 1.14e-9 IgG glycosylation; CRC cis rs6790105 1 rs6790105 chr3:49393409 C/T cg07636037 chr3:49044803 WDR6 0.66 8.14 0.41 8.02e-15 Childhood ear infection; CRC cis rs6964587 0.900 rs6972027 chr7:91781380 T/C cg17063962 chr7:91808500 NA 0.85 15.11 0.64 1.46e-39 Breast cancer; CRC trans rs3749237 0.964 rs62260719 chr3:49852419 G/A cg21665057 chr3:196295764 WDR53;FBXO45 0.55 7.69 0.39 1.76e-13 Resting heart rate; CRC trans rs1814175 0.765 rs1721990 chr11:49912154 G/C cg15704280 chr7:45808275 SEPT13 -1.01 -19.95 -0.74 1.32e-58 Height; CRC cis rs11229555 0.609 rs12273635 chr11:58186327 T/C cg15696309 chr11:58395628 NA -0.81 -10.31 -0.49 8.83e-22 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; CRC cis rs9814567 1.000 rs1814336 chr3:134200823 G/C cg06541857 chr3:134203789 ANAPC13;CEP63 -0.42 -6.31 -0.33 8.79e-10 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs910316 0.763 rs4556 chr14:75476071 G/C cg08847533 chr14:75593920 NEK9 0.87 15.21 0.64 6.01e-40 Height; CRC cis rs2692947 0.696 rs1724121 chr2:96808549 T/C cg23100626 chr2:96804247 ASTL 0.28 7.62 0.39 2.78e-13 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; CRC cis rs4731207 0.596 rs2170351 chr7:124642197 A/G cg23710748 chr7:124431027 NA -0.43 -6.86 -0.35 3.42e-11 Cutaneous malignant melanoma; CRC cis rs9467773 0.506 rs9393709 chr6:26365147 C/T cg14345882 chr6:26364793 BTN3A2 0.43 6.65 0.34 1.19e-10 Intelligence (multi-trait analysis); CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg14778235 chr10:102589102 PAX2 -0.37 -6.33 -0.33 8.12e-10 Myopia (pathological); CRC cis rs6952808 0.756 rs4719311 chr7:1881813 C/T cg02951883 chr7:2050386 MAD1L1 -0.62 -10.0 -0.48 9.97e-21 Bipolar disorder and schizophrenia; CRC cis rs72615157 0.664 rs6953580 chr7:99825275 A/G cg07160278 chr7:100027354 MEPCE;ZCWPW1 0.63 7.49 0.38 6.42e-13 Lung function (FEV1/FVC); CRC cis rs910316 0.737 rs175499 chr14:75535927 G/A cg08847533 chr14:75593920 NEK9 -0.86 -14.97 -0.64 5.54e-39 Height; CRC cis rs6502050 0.835 rs6502069 chr17:80112599 G/T cg09264619 chr17:80180166 NA -0.34 -5.81 -0.3 1.5e-8 Life satisfaction; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg15985338 chr7:6048868 PMS2;AIMP2 0.49 8.14 0.41 8.24e-15 Liver disease severity in Alagille syndrome; CRC cis rs3806843 1.000 rs7701755 chr5:140182101 G/T cg16607685 chr5:140181889 PCDHA2;PCDHA1;PCDHA3 -0.27 -6.27 -0.33 1.13e-9 Depressive symptoms (multi-trait analysis); CRC cis rs9372498 0.536 rs17080302 chr6:118854037 A/G cg22561889 chr6:118971681 C6orf204 0.51 6.65 0.34 1.26e-10 Diastolic blood pressure; CRC cis rs10743315 0.778 rs1586843 chr12:19354550 T/C cg02471346 chr12:19282374 PLEKHA5 -0.62 -7.89 -0.4 4.41e-14 Gut microbiota (bacterial taxa); CRC cis rs12701220 0.894 rs12701406 chr7:1050283 G/A cg00990874 chr7:1149470 C7orf50 -0.58 -6.77 -0.35 5.81e-11 Bronchopulmonary dysplasia; CRC cis rs1005277 0.579 rs2474568 chr10:38383147 A/T cg00409905 chr10:38381863 ZNF37A -0.67 -11.22 -0.53 6.01e-25 Extrinsic epigenetic age acceleration; CRC cis rs4665809 0.589 rs4665842 chr2:26448954 A/G cg08067268 chr2:26466485 HADHB;HADHA -0.66 -8.42 -0.42 1.18e-15 Gut microbiome composition (summer); CRC cis rs7927771 0.839 rs59360790 chr11:47669175 T/C cg05585544 chr11:47624801 NA -0.44 -7.8 -0.39 8.54e-14 Subjective well-being; CRC cis rs3733585 0.673 rs9994937 chr4:9964799 G/T cg00071950 chr4:10020882 SLC2A9 -0.55 -9.79 -0.47 5.05e-20 Cleft plate (environmental tobacco smoke interaction); CRC cis rs10911232 0.507 rs4652764 chr1:182994115 C/T ch.1.3577855R chr1:183094577 LAMC1 0.85 14.42 0.62 7.21e-37 Hypertriglyceridemia; CRC cis rs561341 0.883 rs4450460 chr17:30201309 C/T cg19193384 chr17:30244184 NA 0.47 5.72 0.3 2.36e-8 Hip circumference adjusted for BMI; CRC cis rs763014 0.932 rs2384975 chr16:651115 G/T cg04497992 chr16:616212 NHLRC4 0.45 7.32 0.37 1.95e-12 Height; CRC cis rs881375 0.631 rs10739577 chr9:123668854 C/T cg14255062 chr9:123606675 PSMD5;LOC253039 0.39 6.08 0.32 3.26e-9 Rheumatoid arthritis; CRC cis rs909674 0.818 rs5757678 chr22:39843409 A/G cg05872129 chr22:39784769 NA 0.49 9.2 0.45 4.13e-18 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; CRC cis rs7914558 0.901 rs35525740 chr10:104941112 A/T cg15744005 chr10:104629667 AS3MT -0.34 -7.32 -0.37 1.94e-12 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs6831352 0.879 rs67311928 chr4:100048999 A/G cg13256891 chr4:100009986 ADH5 -0.66 -8.89 -0.44 4.04e-17 Alcohol dependence; CRC cis rs2932538 0.922 rs12136781 chr1:113090655 C/T cg22162597 chr1:113214053 CAPZA1 0.7 9.9 0.48 2.18e-20 Systolic blood pressure;Diastolic blood pressure;Hypertension;Blood pressure; CRC cis rs17767392 0.781 rs8015644 chr14:71842729 C/T cg13720639 chr14:72061746 SIPA1L1 -0.44 -5.81 -0.31 1.47e-8 Mitral valve prolapse; CRC cis rs4073582 0.595 rs2508657 chr11:66043898 G/A cg16950941 chr11:66035639 RAB1B 0.71 12.11 0.56 3.52e-28 Gout; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg15011721 chr7:56032604 GBAS 0.45 6.55 0.34 2.26e-10 Anxiety disorder; CRC cis rs2516839 0.652 rs2774276 chr1:161011716 G/C cg11578532 chr1:161008127 TSTD1 0.32 6.65 0.34 1.25e-10 Granulocyte percentage of myeloid white cells; CRC cis rs4588572 0.601 rs10942855 chr5:77737529 G/A cg11547950 chr5:77652471 NA -0.52 -7.01 -0.36 1.32e-11 Triglycerides; CRC cis rs1218582 0.741 rs883718 chr1:154846274 C/T cg06221963 chr1:154839813 KCNN3 -0.81 -17.34 -0.69 2.64e-48 Prostate cancer; CRC cis rs6686643 1.000 rs959617 chr1:165616881 C/G cg19407955 chr1:165599744 MGST3 -0.43 -5.63 -0.3 3.94e-8 Total ventricular volume; CRC trans rs804280 0.509 rs13276433 chr8:11783036 A/G cg08975724 chr8:8085496 FLJ10661 0.4 6.31 0.33 9.25e-10 Myopia (pathological); CRC cis rs7666738 0.830 rs28622458 chr4:98916651 A/G cg17366294 chr4:99064904 C4orf37 0.41 6.73 0.35 7.45e-11 Colonoscopy-negative controls vs population controls; CRC cis rs6121246 0.529 rs6060174 chr20:30183538 G/A cg18721089 chr20:30220636 NA -0.52 -7.93 -0.4 3.54e-14 Mean corpuscular hemoglobin; CRC cis rs9611519 0.929 rs4821991 chr22:41440683 T/C cg03806693 chr22:41940476 POLR3H -0.58 -7.45 -0.38 8.28e-13 Neuroticism; CRC cis rs62064224 0.509 rs2302276 chr17:30791503 C/T cg21839984 chr17:30846986 MYO1D -0.33 -5.61 -0.3 4.33e-8 Schizophrenia; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg11255154 chr2:191879104 STAT1 0.38 6.1 0.32 3.02e-9 Liver disease severity in Alagille syndrome; CRC cis rs116095464 0.558 rs59284383 chr5:284525 C/G cg22857025 chr5:266934 NA -1.24 -16.52 -0.67 4.4e-45 Breast cancer; CRC cis rs10779751 0.770 rs11121691 chr1:11181327 C/T cg08854313 chr1:11322531 MTOR -0.57 -7.36 -0.38 1.46e-12 Body mass index; CRC trans rs804280 1.000 rs804281 chr8:11611865 A/G cg06636001 chr8:8085503 FLJ10661 0.46 6.6 0.34 1.69e-10 Myopia (pathological); CRC cis rs11098499 0.954 rs6849171 chr4:120409549 G/A cg24375607 chr4:120327624 NA 0.49 7.65 0.39 2.17e-13 Corneal astigmatism; CRC cis rs1499614 0.831 rs3800822 chr7:66147149 A/G cg12463550 chr7:65579703 CRCP -0.65 -5.91 -0.31 8.34e-9 Gout; CRC cis rs10504229 1.000 rs56168206 chr8:58184485 G/A cg01721255 chr8:58191610 C8orf71 0.49 6.17 0.32 2e-9 Developmental language disorder (linguistic errors); CRC cis rs300703 0.748 rs4484059 chr2:286812 G/A cg21211680 chr2:198530 NA 0.96 8.28 0.42 3.22e-15 Blood protein levels; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg20150887 chr17:43210745 PLCD3;ACBD4 0.44 6.62 0.34 1.42e-10 Response to antipsychotic treatment; CRC cis rs13108904 0.901 rs7695691 chr4:1304632 A/G cg02018176 chr4:1364513 KIAA1530 0.38 6.3 0.33 9.3e-10 Obesity-related traits; CRC cis rs3126085 0.935 rs1390485 chr1:152182168 C/T cg09127314 chr1:152161683 NA -0.46 -5.66 -0.3 3.27e-8 Atopic dermatitis; CRC cis rs4975616 0.804 rs457130 chr5:1336178 A/T cg26373071 chr5:1325741 CLPTM1L 0.47 8.45 0.42 9.75e-16 Lung cancer; CRC cis rs763014 0.966 rs4247097 chr16:654224 G/A cg02475695 chr16:616220 NHLRC4 0.48 8.0 0.4 2.18e-14 Height; CRC cis rs7552404 1.000 rs28602663 chr1:76235355 C/T cg03433033 chr1:76189801 ACADM 0.77 10.47 0.5 2.55e-22 Blood metabolite levels;Acylcarnitine levels; CRC cis rs79976124 0.797 rs79522358 chr6:66641140 C/G cg07460842 chr6:66804631 NA 0.75 9.38 0.46 1.07e-18 Type 2 diabetes; CRC cis rs17253792 0.822 rs79873916 chr14:56172631 G/C cg01858014 chr14:56050164 KTN1 -0.92 -7.3 -0.37 2.14e-12 Putamen volume; CRC cis rs6952808 0.723 rs4721287 chr7:2028663 A/C cg00106254 chr7:1943704 MAD1L1 -0.56 -8.2 -0.41 5.62e-15 Bipolar disorder and schizophrenia; CRC cis rs3796352 1.000 rs61172708 chr3:52996052 T/G cg07884673 chr3:53033167 SFMBT1 0.7 6.15 0.32 2.23e-9 Immune reponse to smallpox (secreted IL-2); CRC cis rs7072216 0.763 rs7910014 chr10:100172110 C/T cg26618903 chr10:100175079 PYROXD2 -0.55 -8.99 -0.44 2.03e-17 Metabolite levels; CRC cis rs9362426 0.708 rs4707365 chr6:88100912 A/G cg08069147 chr6:88032118 GJB7;C6orf162 0.48 6.42 0.33 4.87e-10 Depressive episodes in bipolar disorder; CRC trans rs75804782 0.580 rs72987332 chr2:239362529 G/T cg01134436 chr17:81009848 B3GNTL1 0.7 6.42 0.33 4.8e-10 Morning vs. evening chronotype;Chronotype; CRC cis rs734999 0.572 rs3748816 chr1:2526746 A/G cg18854424 chr1:2615690 NA 0.5 9.88 0.48 2.55e-20 Ulcerative colitis; CRC cis rs6938 0.534 rs12904897 chr15:75217686 A/G cg14664628 chr15:75095509 CSK -0.65 -10.39 -0.5 4.53e-22 Breast cancer; CRC cis rs7586879 0.639 rs13407913 chr2:25097644 A/G cg22495460 chr2:25135724 ADCY3 -0.85 -16.31 -0.67 3.12e-44 Body mass index; CRC cis rs853679 0.517 rs9295759 chr6:28124469 C/T cg12963246 chr6:28129442 ZNF389 0.49 5.7 0.3 2.71e-8 Depression; CRC cis rs9837602 0.592 rs1606481 chr3:99427552 A/G cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G -0.46 -5.76 -0.3 1.96e-8 Breast cancer; CRC cis rs7605827 0.930 rs1015835 chr2:15625768 T/C cg19274914 chr2:15703543 NA 0.39 5.95 0.31 6.89e-9 Educational attainment (years of education); CRC trans rs2727020 0.894 rs2866361 chr11:49372481 A/G cg15704280 chr7:45808275 SEPT13 -0.75 -9.95 -0.48 1.45e-20 Coronary artery disease; CRC cis rs2408955 0.522 rs4760612 chr12:48421856 C/T cg00601486 chr12:48723148 H1FNT -0.33 -6.25 -0.33 1.26e-9 Glycated hemoglobin levels; CRC cis rs10504229 0.906 rs7842855 chr8:58167718 G/C cg02290350 chr8:58132656 NA -0.44 -6.96 -0.36 1.82e-11 Developmental language disorder (linguistic errors); CRC trans rs35110281 0.774 rs1003280 chr21:44997322 A/G cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.44 7.18 0.37 4.82e-12 Mean corpuscular volume; CRC cis rs362272 0.505 rs13104157 chr4:3366950 T/C cg08741688 chr4:3415352 RGS12 -0.41 -5.82 -0.31 1.41e-8 Serum sulfate level; CRC trans rs2055729 0.677 rs6990268 chr8:9741171 G/A cg06636001 chr8:8085503 FLJ10661 -0.53 -6.77 -0.35 5.78e-11 Multiple myeloma (hyperdiploidy); CRC cis rs853679 0.517 rs9368552 chr6:28068426 A/G cg21251018 chr6:28226885 NKAPL 0.48 6.26 0.33 1.17e-9 Depression; CRC cis rs1799949 0.550 rs2343818 chr17:41409774 G/A cg05368731 chr17:41323189 NBR1 0.64 9.34 0.46 1.51e-18 Menopause (age at onset); CRC cis rs6598955 0.756 rs10902723 chr1:26568542 T/C cg00852783 chr1:26633632 UBXN11 0.44 7.1 0.36 7.52e-12 Obesity-related traits; CRC trans rs951252 0.504 rs11734405 chr4:146081096 C/T cg13731338 chr3:128145454 NA 0.44 5.98 0.31 5.71e-9 Hip circumference; CRC cis rs7666738 0.822 rs6815312 chr4:99058220 T/C cg05340658 chr4:99064831 C4orf37 0.6 9.25 0.45 2.97e-18 Colonoscopy-negative controls vs population controls; CRC cis rs8064299 1.000 rs8064299 chr17:72762646 C/A cg21922841 chr17:72744131 SLC9A3R1 0.28 5.84 0.31 1.28e-8 Monocyte count; CRC cis rs1707322 1.000 rs7553924 chr1:46352624 T/C cg06784218 chr1:46089804 CCDC17 0.52 9.12 0.45 7.89e-18 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs2213920 0.679 rs6415820 chr9:118231832 A/C cg13918206 chr9:118159781 DEC1 0.64 6.07 0.32 3.49e-9 Docetaxel-induced peripheral neuropathy in metastatic castrate-resistant prostate cancer; CRC cis rs8180040 0.701 rs13066214 chr3:47033937 C/T cg10298567 chr3:47292165 KIF9 -0.37 -6.04 -0.32 4.2e-9 Colorectal cancer; CRC cis rs751837 0.591 rs10138056 chr14:103424854 A/G cg10087771 chr14:103399429 CDC42BPB 0.67 6.58 0.34 1.83e-10 Large B-cell lymphoma; CRC cis rs881375 0.967 rs10435844 chr9:123668199 G/T cg14255062 chr9:123606675 PSMD5;LOC253039 0.42 6.06 0.32 3.7e-9 Rheumatoid arthritis; CRC cis rs4664293 0.625 rs13006088 chr2:160509426 A/G cg08347373 chr2:160653686 CD302 0.39 6.68 0.35 1.03e-10 Monocyte percentage of white cells; CRC cis rs950169 0.580 rs62021208 chr15:85196244 G/A cg11189052 chr15:85197271 WDR73 0.66 9.6 0.47 2.09e-19 Schizophrenia; CRC cis rs9491140 0.539 rs11154228 chr6:124686042 A/G cg19267163 chr6:125004984 NKAIN2 0.45 6.1 0.32 2.95e-9 Neuroticism; CRC cis rs10028773 0.515 rs9994488 chr4:120587781 C/T cg10183150 chr4:120222239 C4orf3 -0.33 -5.99 -0.31 5.44e-9 Educational attainment; CRC cis rs1865760 0.516 rs9393683 chr6:26066198 A/G cg17691542 chr6:26056736 HIST1H1C 0.55 8.44 0.42 1.06e-15 Height; CRC cis rs10504229 1.000 rs17805332 chr8:58169798 A/G cg24829409 chr8:58192753 C8orf71 -0.68 -11.53 -0.54 4.56e-26 Developmental language disorder (linguistic errors); CRC trans rs12432203 1.000 rs3507 chr14:51730548 G/C cg14592830 chr9:122318704 NA 0.59 6.12 0.32 2.62e-9 Cancer; CRC cis rs4727963 0.755 rs1525471 chr7:122733962 C/T cg03640110 chr7:122635026 TAS2R16 0.35 6.36 0.33 6.9e-10 Adverse response to chemotherapy (neutropenia/leucopenia) (docetaxel); CRC cis rs2153535 0.580 rs6597326 chr6:8482019 A/C cg21535247 chr6:8435926 SLC35B3 0.5 7.54 0.38 4.72e-13 Motion sickness; CRC cis rs4665809 1.000 rs6749855 chr2:26255263 A/G cg04944784 chr2:26401820 FAM59B -0.58 -7.29 -0.37 2.28e-12 Gut microbiome composition (summer); CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg16139199 chr18:19180362 ESCO1 -0.48 -5.97 -0.31 5.99e-9 Diisocyanate-induced asthma; CRC cis rs796364 0.951 rs281776 chr2:200834282 T/G cg12253985 chr2:200820533 C2orf60;C2orf47 0.59 6.41 0.33 4.93e-10 Schizophrenia; CRC cis rs78456975 0.506 rs13402886 chr2:1575348 G/A cg26248373 chr2:1572462 NA -0.8 -11.74 -0.54 8.41e-27 Placebo response in major depressive disorder (% change in symptom score); CRC cis rs4713118 0.540 rs469227 chr6:27970705 A/C cg20933634 chr6:27740509 NA 0.42 5.85 0.31 1.21e-8 Parkinson's disease; CRC cis rs11212617 0.967 rs4585 chr11:108239628 G/T cg01991180 chr11:108092276 ATM;NPAT 0.44 6.62 0.34 1.5e-10 Response to metformin in type 2 diabetes (glycemic); CRC cis rs7552404 0.960 rs61797339 chr1:76189946 G/T cg22875332 chr1:76189707 ACADM 0.7 9.54 0.47 3.31e-19 Blood metabolite levels;Acylcarnitine levels; CRC cis rs7618915 0.571 rs12487445 chr3:52618319 A/C cg10802521 chr3:52805072 NEK4 -0.58 -8.92 -0.44 3.34e-17 Bipolar disorder; CRC cis rs10504229 0.683 rs7827014 chr8:58132230 G/A cg22535103 chr8:58192502 C8orf71 -0.7 -9.34 -0.46 1.47e-18 Developmental language disorder (linguistic errors); CRC trans rs208520 0.731 rs12206488 chr6:66999917 G/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.93 10.73 0.51 3.03e-23 Exhaled nitric oxide output; CRC cis rs8014204 0.869 rs2070599 chr14:75361177 C/G cg03030879 chr14:75389066 RPS6KL1 0.51 8.19 0.41 5.79e-15 Caffeine consumption; CRC trans rs57221529 0.825 rs7443550 chr5:578404 G/T cg25482853 chr8:67687455 SGK3 1.25 14.99 0.64 4.45e-39 Lung disease severity in cystic fibrosis; CRC cis rs597539 0.652 rs627731 chr11:68698663 A/C cg06112835 chr11:68658793 MRPL21 0.43 6.8 0.35 4.95e-11 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs950169 0.544 rs62021193 chr15:85170583 C/G cg17507749 chr15:85114479 UBE2QP1 0.63 9.08 0.45 9.95e-18 Schizophrenia; CRC cis rs12497850 0.931 rs28642807 chr3:48926816 A/G cg07636037 chr3:49044803 WDR6 1.02 17.98 0.7 7.89e-51 Parkinson's disease; CRC cis rs5750830 0.594 rs1010170 chr22:39778327 C/T cg24399712 chr22:39784796 NA 0.51 8.95 0.44 2.57e-17 Intelligence (multi-trait analysis); CRC trans rs11098499 0.863 rs2291185 chr4:120434833 C/A cg25214090 chr10:38739885 LOC399744 0.62 9.71 0.47 9.26e-20 Corneal astigmatism; CRC cis rs3126085 0.935 rs4845431 chr1:152227977 A/G cg09127314 chr1:152161683 NA 0.5 6.41 0.33 5.03e-10 Atopic dermatitis; CRC trans rs35851103 0.600 rs4841662 chr8:11843758 A/G cg06636001 chr8:8085503 FLJ10661 -0.56 -8.24 -0.41 4.11e-15 Neuroticism; CRC cis rs172166 0.694 rs203877 chr6:28048624 T/C cg02683197 chr6:28174875 NA 0.64 8.9 0.44 3.89e-17 Cardiac Troponin-T levels; CRC trans rs703108 0.731 rs7898954 chr10:22323646 A/G cg26611836 chr5:126112609 LMNB1 -0.55 -6.48 -0.34 3.43e-10 Monocyte percentage of white cells; CRC cis rs10982256 0.766 rs1535959 chr9:117248479 G/A cg13636371 chr9:117264095 DFNB31 0.42 7.97 0.4 2.55e-14 Bipolar disorder; CRC cis rs61008539 0.853 rs10950611 chr7:861094 G/T cg00475322 chr7:917719 C7orf20 0.43 7.66 0.39 2.05e-13 Perceived unattractiveness to mosquitoes; CRC cis rs2014572 0.967 rs8100154 chr19:57765432 A/G cg24459738 chr19:57751996 ZNF805 -0.57 -9.05 -0.45 1.25e-17 Hyperactive-impulsive symptoms; CRC cis rs2075371 0.829 rs9641970 chr7:134004887 C/A cg02659138 chr7:134003124 SLC35B4 0.42 7.24 0.37 3.1e-12 Mean platelet volume; CRC cis rs2811415 0.597 rs9824536 chr3:127763956 C/A cg13719885 chr3:127795394 NA -0.37 -5.72 -0.3 2.37e-8 Lung function (FEV1/FVC); CRC cis rs7301826 0.651 rs7971046 chr12:131286807 G/A cg11011512 chr12:131303247 STX2 0.38 5.7 0.3 2.73e-8 Plasma plasminogen activator levels; CRC cis rs6964587 0.836 rs757040 chr7:91552016 A/G cg17063962 chr7:91808500 NA -0.72 -10.81 -0.51 1.71e-23 Breast cancer; CRC cis rs870825 0.616 rs10428373 chr4:185639002 A/G cg21366198 chr4:185655624 MLF1IP -0.59 -6.6 -0.34 1.6e-10 Blood protein levels; CRC cis rs11255291 1.000 rs10905218 chr10:7733898 C/T cg00997801 chr10:7671259 ITIH5 0.42 6.13 0.32 2.51e-9 Ovarian reserve; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg25846339 chr11:85359022 TMEM126A 0.5 7.17 0.37 4.97e-12 Response to antipsychotic treatment; CRC cis rs1697139 0.935 rs1625369 chr5:66513022 C/T cg16691251 chr5:66510806 NA 0.58 11.56 0.54 3.73e-26 Breast cancer; CRC cis rs2762353 0.574 rs34067542 chr6:25728210 T/A cg03517284 chr6:25882590 NA 0.76 10.78 0.51 2.12e-23 Blood metabolite levels; CRC trans rs2727020 0.617 rs1917311 chr11:49422665 C/T cg03929089 chr4:120376271 NA -0.87 -15.95 -0.66 8.1e-43 Coronary artery disease; CRC cis rs9616064 0.506 rs2542038 chr22:47059282 C/T cg05621596 chr22:47072043 GRAMD4 -0.69 -12.07 -0.55 5.12e-28 Urate levels in obese individuals; CRC cis rs12926788 0.546 rs200537 chr16:24747787 G/C cg00339695 chr16:24857497 SLC5A11 -0.43 -9.02 -0.45 1.62e-17 Ejection fraction in Tripanosoma cruzi seropositivity; CRC cis rs6456156 0.819 rs7765739 chr6:167518472 C/T cg07741184 chr6:167504864 NA 0.47 8.09 0.41 1.17e-14 Primary biliary cholangitis; CRC cis rs910316 0.692 rs7156586 chr14:75506230 A/T cg08847533 chr14:75593920 NEK9 0.8 12.28 0.56 8.31e-29 Height; CRC cis rs9875589 0.628 rs62234602 chr3:14002170 A/G cg19554555 chr3:13937349 NA 0.45 6.15 0.32 2.27e-9 Ovarian reserve; CRC cis rs2228479 0.850 rs11639788 chr16:89807543 G/A cg06558623 chr16:89946397 TCF25 1.14 10.79 0.51 1.99e-23 Skin colour saturation; CRC trans rs3806843 0.868 rs2563281 chr5:140131219 T/A cg06840491 chr10:48416966 GDF2 -0.35 -6.04 -0.32 4.16e-9 Depressive symptoms (multi-trait analysis); CRC cis rs8180040 0.726 rs2385867 chr3:47059323 C/T cg02527881 chr3:46936655 PTH1R -0.38 -7.0 -0.36 1.48e-11 Colorectal cancer; CRC cis rs40363 0.723 rs8060367 chr16:3537919 C/A cg21433313 chr16:3507492 NAT15 -0.65 -6.45 -0.34 4.01e-10 Tuberculosis; CRC cis rs1448094 0.511 rs11610371 chr12:86163487 A/G cg02569458 chr12:86230093 RASSF9 0.46 7.46 0.38 7.83e-13 Major depressive disorder; CRC cis rs9894429 1.000 rs7406003 chr17:79597597 C/T cg21984481 chr17:79567631 NPLOC4 -0.53 -9.8 -0.48 4.71e-20 Eye color traits; CRC cis rs2944755 0.919 rs2944754 chr8:141574350 A/G cg07466463 chr8:141574207 EIF2C2 -0.4 -5.82 -0.31 1.38e-8 Thiazide-induced adverse metabolic effects in hypertensive patients; CRC cis rs7429990 0.864 rs7629850 chr3:47857082 T/C cg11946769 chr3:48343235 NME6 -0.46 -5.83 -0.31 1.29e-8 Educational attainment (years of education); CRC cis rs2836974 0.897 rs12481860 chr21:40537836 T/A cg17971929 chr21:40555470 PSMG1 0.81 11.93 0.55 1.61e-27 Cognitive function; CRC cis rs8077889 0.645 rs1230396 chr17:41843029 A/C cg25876840 chr17:41920477 NA -0.46 -7.27 -0.37 2.63e-12 Triglycerides; CRC cis rs9322193 0.923 rs1934534 chr6:150033032 A/G cg05861140 chr6:150128134 PCMT1 -0.38 -6.24 -0.33 1.33e-9 Lung cancer; CRC cis rs905456 0.716 rs6804368 chr3:30753573 A/G cg06106510 chr3:30762233 NA 0.33 6.05 0.32 3.87e-9 Positive affect; CRC cis rs2243480 1.000 rs160637 chr7:65584318 C/T cg25985355 chr7:65971099 NA -0.49 -5.73 -0.3 2.27e-8 Diabetic kidney disease; CRC cis rs6502050 0.835 rs9900128 chr17:80087920 A/T cg11859384 chr17:80120422 CCDC57 -0.37 -5.92 -0.31 7.94e-9 Life satisfaction; CRC cis rs7811142 0.830 rs6955367 chr7:99961194 A/G cg00814883 chr7:100076585 TSC22D4 -0.68 -8.97 -0.44 2.27e-17 Platelet count; CRC cis rs11122272 0.735 rs2808601 chr1:231536571 A/G cg06096015 chr1:231504339 EGLN1 0.4 6.04 0.32 4.19e-9 Hemoglobin concentration; CRC cis rs4819052 0.851 rs4819044 chr21:46660118 G/A cg11663144 chr21:46675770 NA -0.8 -13.38 -0.59 6.77e-33 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg13028789 chr6:34856920 ANKS1A;TAF11 0.37 6.16 0.32 2.07e-9 Liver disease severity in Alagille syndrome; CRC cis rs6582630 0.502 rs4559747 chr12:38436235 G/A cg13010199 chr12:38710504 ALG10B 0.46 6.27 0.33 1.16e-9 Drug-induced liver injury (flucloxacillin); CRC cis rs2180341 1.000 rs3798853 chr6:127636823 C/T cg27446573 chr6:127587934 RNF146 -0.96 -13.93 -0.61 5.22e-35 Breast cancer; CRC cis rs977987 0.806 rs56343285 chr16:75409797 A/G cg03315344 chr16:75512273 CHST6 0.53 8.85 0.44 5.48e-17 Dupuytren's disease; CRC cis rs4713118 0.869 rs6914924 chr6:27711530 C/T cg15845792 chr6:28175446 NA 0.65 9.11 0.45 7.98e-18 Parkinson's disease; CRC cis rs7617480 0.648 rs4974083 chr3:49000626 A/G cg07636037 chr3:49044803 WDR6 0.87 10.61 0.5 8.32e-23 Subjective well-being (multi-trait analysis);Menarche (age at onset); CRC cis rs9372498 0.536 rs62422229 chr6:118959288 T/C cg15382696 chr6:118971807 C6orf204 0.59 7.53 0.38 4.79e-13 Diastolic blood pressure; CRC cis rs3772130 0.583 rs11710169 chr3:121426655 A/G cg20356878 chr3:121714668 ILDR1 0.56 10.13 0.49 3.62e-21 Cognitive performance; CRC cis rs9611519 0.894 rs9623320 chr22:41478482 G/A cg06634786 chr22:41940651 POLR3H -0.44 -5.69 -0.3 2.81e-8 Neuroticism; CRC cis rs11997175 0.766 rs7387133 chr8:33727045 C/G cg04338863 chr8:33670619 NA -0.36 -5.79 -0.3 1.63e-8 Body mass index; CRC cis rs2243480 1.000 rs465359 chr7:65558164 C/T cg25985355 chr7:65971099 NA -0.47 -5.65 -0.3 3.54e-8 Diabetic kidney disease; CRC cis rs801193 1.000 rs2286684 chr7:66129830 G/T cg00343986 chr7:65444356 GUSB -0.49 -7.23 -0.37 3.38e-12 Aortic root size; CRC cis rs853679 0.517 rs3757185 chr6:28107776 T/A cg12273811 chr6:28175739 NA 0.73 9.36 0.46 1.34e-18 Depression; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg02970425 chr20:48552805 RNF114 0.45 6.07 0.32 3.45e-9 Thyroid stimulating hormone; CRC cis rs34891900 0.507 rs2008085 chr22:18204316 T/G cg19898043 chr22:18121309 BCL2L13 0.53 8.44 0.42 9.98e-16 Sum neutrophil eosinophil counts; CRC cis rs1707322 0.758 rs10789474 chr1:46250040 G/T cg06784218 chr1:46089804 CCDC17 0.6 11.05 0.52 2.37e-24 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs7258465 0.931 rs76195 chr19:18629830 A/G cg10790698 chr19:18539756 SSBP4 -0.45 -8.53 -0.43 5.39e-16 Breast cancer; CRC cis rs66573146 0.572 rs66819208 chr4:6946128 A/G cg26116260 chr4:7069785 GRPEL1 -0.59 -5.65 -0.3 3.54e-8 Granulocyte percentage of myeloid white cells; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg22943607 chr19:4400723 SH3GL1 0.42 6.37 0.33 6.51e-10 Liver disease severity in Alagille syndrome; CRC cis rs514406 0.505 rs425520 chr1:53179805 C/G cg24675658 chr1:53192096 ZYG11B -0.67 -10.06 -0.48 6.41e-21 Monocyte count; CRC cis rs10256972 0.641 rs12702017 chr7:1129413 C/T cg07092213 chr7:1199455 ZFAND2A -0.41 -5.86 -0.31 1.15e-8 Longevity;Endometriosis; CRC cis rs10504229 1.000 rs55787104 chr8:58178519 C/T cg01721255 chr8:58191610 C8orf71 0.49 6.08 0.32 3.34e-9 Developmental language disorder (linguistic errors); CRC cis rs35110281 0.807 rs2838328 chr21:45023234 G/C cg04455712 chr21:45112962 RRP1B 0.39 7.52 0.38 5.28e-13 Mean corpuscular volume; CRC cis rs17767392 0.846 rs61991200 chr14:71762569 A/G cg13720639 chr14:72061746 SIPA1L1 -0.45 -6.06 -0.32 3.68e-9 Mitral valve prolapse; CRC cis rs10504229 0.728 rs17804720 chr8:58154565 T/C cg02725872 chr8:58115012 NA -0.57 -9.07 -0.45 1.09e-17 Developmental language disorder (linguistic errors); CRC cis rs853679 1.000 rs735765 chr6:28170297 G/A cg15786705 chr6:28176104 NA 0.75 7.4 0.38 1.13e-12 Depression; CRC trans rs60843830 1.000 rs56167434 chr2:282137 G/C cg11347411 chr7:150020925 ACTR3C;LRRC61 0.62 9.69 0.47 1.1e-19 Spherical equivalent (joint analysis main effects and education interaction); CRC cis rs2717559 0.683 rs2717611 chr8:143879927 C/T cg20041105 chr8:143859282 LYNX1 -0.5 -9.12 -0.45 7.8e-18 Urinary tract infection frequency; CRC cis rs13118159 0.742 rs34947293 chr4:1335034 T/C cg15763984 chr4:1342303 KIAA1530 0.48 8.41 0.42 1.3e-15 Longevity; CRC cis rs2882667 0.690 rs274118 chr5:138064887 A/G cg09476006 chr5:138032270 NA 0.58 10.42 0.5 3.74e-22 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs4713118 0.826 rs2893929 chr6:27738732 A/T cg25164649 chr6:28176230 NA 0.7 7.91 0.4 3.86e-14 Parkinson's disease; CRC cis rs932541 1.000 rs6105612 chr20:16458404 T/G cg17003395 chr20:16555519 KIF16B 0.42 5.8 0.3 1.58e-8 Intelligence; CRC cis rs1552244 1.000 rs7628448 chr3:10146828 G/A cg08888203 chr3:10149979 C3orf24 0.7 9.26 0.45 2.78e-18 Alzheimer's disease; CRC cis rs1552244 0.882 rs17050660 chr3:10001772 A/G cg02579736 chr3:10068473 FANCD2;CIDECP -0.92 -11.98 -0.55 1.09e-27 Alzheimer's disease; CRC cis rs2933343 0.700 rs789233 chr3:128603150 G/T cg11901034 chr3:128598214 ACAD9 -0.55 -8.18 -0.41 6.37e-15 IgG glycosylation; CRC cis rs832540 0.864 rs252908 chr5:56120686 T/C cg20203395 chr5:56204925 C5orf35 -0.41 -5.77 -0.3 1.84e-8 Coronary artery disease; CRC cis rs2380220 0.541 rs9285413 chr6:96023439 G/A cg07718321 chr6:96025334 MANEA 0.58 7.42 0.38 9.96e-13 Behavioural disinhibition (generation interaction); CRC cis rs972578 0.967 rs6002985 chr22:43333427 C/T cg01576275 chr22:43409880 NA -0.42 -6.77 -0.35 6.07e-11 Mean platelet volume; CRC cis rs11098499 0.818 rs12498599 chr4:120468503 C/T cg09307838 chr4:120376055 NA 0.67 10.3 0.49 9.15e-22 Corneal astigmatism; CRC cis rs294883 0.789 rs397344 chr6:159694590 C/T cg14500486 chr6:159655392 FNDC1 -0.36 -5.85 -0.31 1.16e-8 Coronary artery disease; CRC cis rs875971 0.862 rs3926380 chr7:66080645 G/T cg18252515 chr7:66147081 NA 0.43 6.14 0.32 2.35e-9 Aortic root size; CRC cis rs7044106 0.791 rs10985009 chr9:123493039 C/T cg09586646 chr9:123605570 PSMD5;LOC253039 -0.72 -10.98 -0.52 4.02e-24 Hip circumference adjusted for BMI; CRC trans rs8073060 0.505 rs225270 chr17:33968871 A/T cg19694781 chr19:47549865 TMEM160 -1.05 -14.7 -0.63 5.76e-38 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; CRC cis rs2976388 0.525 rs2016749 chr8:143836118 G/A cg12516270 chr8:143859308 LYNX1 -0.58 -10.34 -0.5 7.1e-22 Urinary tract infection frequency; CRC cis rs9814567 0.712 rs9838467 chr3:134332222 C/A cg06109529 chr3:134205091 CEP63;ANAPC13 -0.67 -9.58 -0.47 2.53e-19 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs763014 0.932 rs2384975 chr16:651115 G/T cg08989290 chr16:615782 NHLRC4 0.48 9.51 0.46 4.15e-19 Height; CRC trans rs2727020 0.553 rs7479975 chr11:49581964 C/G cg03929089 chr4:120376271 NA -0.93 -17.34 -0.69 2.58e-48 Coronary artery disease; CRC cis rs9733 0.596 rs7538493 chr1:150655421 T/C cg18016565 chr1:150552671 MCL1 0.46 6.74 0.35 6.91e-11 Tonsillectomy; CRC cis rs7647973 0.580 rs12629759 chr3:49237394 T/C cg03060546 chr3:49711283 APEH 0.46 6.74 0.35 7.3e-11 Menarche (age at onset); CRC cis rs13315871 1.000 rs71311864 chr3:58372324 C/T cg20936604 chr3:58311152 NA -0.73 -6.69 -0.35 9.48e-11 Cholesterol, total; CRC cis rs2204008 0.713 rs11173567 chr12:38089375 T/C cg26384229 chr12:38710491 ALG10B 0.63 8.58 0.43 3.93e-16 Bladder cancer; CRC cis rs10883723 0.810 rs1884929 chr10:104275418 C/T cg22532475 chr10:104410764 TRIM8 -0.36 -6.79 -0.35 5.39e-11 Allergic disease (asthma, hay fever or eczema); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg10367214 chr6:139094545 CCDC28A 0.39 6.25 0.33 1.3e-9 Liver disease severity in Alagille syndrome; CRC cis rs754466 0.580 rs2579176 chr10:79529350 A/G cg26805224 chr10:79626177 DLG5 -0.49 -7.26 -0.37 2.86e-12 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs2243480 0.808 rs12698508 chr7:65411958 A/T cg18252515 chr7:66147081 NA -1.08 -12.32 -0.56 5.94e-29 Diabetic kidney disease; CRC cis rs6502050 0.805 rs9898326 chr17:80119582 C/T cg11859384 chr17:80120422 CCDC57 -0.36 -5.75 -0.3 2.06e-8 Life satisfaction; CRC cis rs916888 0.821 rs199514 chr17:44856881 G/A cg01570182 chr17:44337453 NA -1.05 -12.2 -0.56 1.69e-28 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs172166 0.694 rs203884 chr6:28077374 G/T cg25164649 chr6:28176230 NA 0.61 8.67 0.43 1.95e-16 Cardiac Troponin-T levels; CRC cis rs8077889 0.917 rs4793038 chr17:41916761 A/T cg25876840 chr17:41920477 NA 0.48 7.37 0.38 1.41e-12 Triglycerides; CRC cis rs796364 0.760 rs2202922 chr2:200882610 C/T cg25936922 chr2:200820526 C2orf60;C2orf47 0.68 6.64 0.34 1.33e-10 Schizophrenia; CRC cis rs10751667 0.643 rs7395592 chr11:934094 C/G cg06064525 chr11:970664 AP2A2 -0.35 -6.91 -0.36 2.51e-11 Alzheimer's disease (late onset); CRC cis rs10504229 1.000 rs73609762 chr8:58192695 A/G cg05313129 chr8:58192883 C8orf71 -0.47 -6.99 -0.36 1.49e-11 Developmental language disorder (linguistic errors); CRC cis rs1403694 0.966 rs1656910 chr3:186438993 A/C cg04611788 chr3:186434169 KNG1 -0.45 -6.95 -0.36 1.93e-11 Blood protein levels; CRC cis rs3091242 0.933 rs10903129 chr1:25768937 A/G cg20684491 chr1:25596433 NA 0.41 7.24 0.37 3.23e-12 Erythrocyte sedimentation rate; CRC cis rs35306767 0.761 rs11253538 chr10:1011166 C/T cg26597838 chr10:835615 NA 0.94 11.01 0.52 3.17e-24 Eosinophil percentage of granulocytes; CRC cis rs908922 0.676 rs528427 chr1:152511507 G/C cg09873164 chr1:152488093 CRCT1 0.38 6.4 0.33 5.37e-10 Hair morphology; CRC trans rs10090774 0.965 rs10106750 chr8:142004909 A/G cg14360659 chr9:137029702 RNU6ATAC 0.45 5.96 0.31 6.33e-9 Acute graft versus host disease in bone marrow transplantation (recipient effect); CRC cis rs853679 0.723 rs9366718 chr6:28205502 A/T cg25164649 chr6:28176230 NA 0.56 5.8 0.3 1.53e-8 Depression; CRC cis rs7772486 0.720 rs6901888 chr6:146023144 A/G cg05347473 chr6:146136440 FBXO30 -0.38 -5.67 -0.3 3.1e-8 Lobe attachment (rater-scored or self-reported); CRC cis rs9399135 0.967 rs59329760 chr6:135342437 G/A cg24558204 chr6:135376177 HBS1L 0.5 8.05 0.41 1.58e-14 Red blood cell count; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg01939414 chr2:103353548 MFSD9 0.49 6.39 0.33 5.54e-10 Thyroid stimulating hormone; CRC cis rs1799949 1.000 rs72829113 chr17:41181835 C/T cg23758822 chr17:41437982 NA 0.8 13.18 0.59 3.91e-32 Menopause (age at onset); CRC trans rs2303319 0.504 rs961421 chr2:162626099 G/C cg22922770 chr7:98923339 ARPC1A -0.67 -5.99 -0.31 5.55e-9 Cognitive function; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg15289517 chr15:65809633 DPP8 0.42 6.42 0.33 4.71e-10 Intelligence (multi-trait analysis); CRC cis rs478304 0.654 rs7934036 chr11:65451020 G/T cg27068330 chr11:65405492 SIPA1 -0.65 -9.88 -0.48 2.44e-20 Acne (severe); CRC cis rs951366 0.559 rs823101 chr1:205667006 T/C cg14159672 chr1:205819179 PM20D1 0.66 9.05 0.45 1.26e-17 Menarche (age at onset); CRC cis rs4862750 0.794 rs7692427 chr4:187901727 G/A cg10295955 chr4:187884368 NA -1.06 -28.72 -0.85 1.21e-91 Lobe attachment (rater-scored or self-reported); CRC cis rs79349575 0.721 rs1008834 chr17:46968008 G/C cg22482690 chr17:47019901 SNF8 0.48 8.18 0.41 6.13e-15 Type 2 diabetes; CRC cis rs61774743 0.557 rs4359027 chr1:41848296 G/A cg08144172 chr1:41849203 NA 0.36 5.9 0.31 9.01e-9 Intelligence (multi-trait analysis); CRC cis rs7044106 0.762 rs7044226 chr9:123466328 G/C cg09586646 chr9:123605570 PSMD5;LOC253039 0.65 9.32 0.46 1.72e-18 Hip circumference adjusted for BMI; CRC cis rs6938 0.618 rs12911254 chr15:75166335 G/A cg05627522 chr15:75251581 NA 0.38 5.93 0.31 7.87e-9 Breast cancer; CRC cis rs2996428 0.561 rs72640913 chr1:3747023 C/G cg17848003 chr1:3704513 LRRC47 0.41 6.06 0.32 3.79e-9 Red cell distribution width; CRC cis rs4862750 0.624 rs34414639 chr4:187873417 C/A cg03452623 chr4:187889614 NA -0.88 -19.34 -0.73 3.42e-56 Lobe attachment (rater-scored or self-reported); CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg21767207 chr19:36236454 PSENEN;U2AF1L4 0.45 7.42 0.38 9.83e-13 Obesity-related traits; CRC cis rs17681684 0.565 rs12150182 chr17:9764757 C/T cg26853458 chr17:9805074 RCVRN 0.53 9.35 0.46 1.41e-18 GIP levels in response to oral glucose tolerance test (fasting); CRC cis rs727479 0.502 rs1065779 chr15:51504811 A/C cg19946085 chr15:51559439 CYP19A1 -0.29 -5.92 -0.31 8.01e-9 Estradiol levels; CRC cis rs10986311 0.775 rs7857897 chr9:127118550 G/A cg14243010 chr9:127117328 LOC100129034;PSMB7 0.4 6.01 0.31 4.97e-9 Vitiligo; CRC cis rs67311347 1.000 rs7642906 chr3:40492633 G/A cg24209194 chr3:40518798 ZNF619 -0.45 -7.02 -0.36 1.3e-11 Renal cell carcinoma; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg26529371 chr19:12911983 PRDX2 0.35 6.16 0.32 2.18e-9 Intelligence (multi-trait analysis); CRC cis rs9368481 1.000 rs9368481 chr6:26961761 C/T cg18867708 chr6:26865862 GUSBL1 -0.42 -5.89 -0.31 9.8e-9 Autism spectrum disorder or schizophrenia; CRC cis rs9549367 0.789 rs2287248 chr13:113889226 T/C cg00898013 chr13:113819073 PROZ -0.46 -6.81 -0.35 4.63e-11 Platelet distribution width; CRC cis rs79387448 0.638 rs6741230 chr2:103069631 C/T cg09003973 chr2:102972529 NA 0.73 7.66 0.39 2.12e-13 Gut microbiota (bacterial taxa); CRC cis rs17270561 0.636 rs6456694 chr6:25712894 C/T cg16482183 chr6:26056742 HIST1H1C 0.72 9.14 0.45 6.37e-18 Iron status biomarkers; CRC cis rs2882667 0.690 rs288016 chr5:138194988 C/T cg09476006 chr5:138032270 NA -0.53 -9.41 -0.46 9.2e-19 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs11098499 0.865 rs2389809 chr4:120377399 T/C cg09307838 chr4:120376055 NA 0.71 11.02 0.52 3.08e-24 Corneal astigmatism; CRC cis rs4665809 0.590 rs2289019 chr2:26420809 G/C cg27170947 chr2:26402098 FAM59B -0.59 -7.62 -0.39 2.79e-13 Gut microbiome composition (summer); CRC cis rs853679 0.517 rs9393887 chr6:28059020 G/A cg18032046 chr6:28092343 ZSCAN16 -0.48 -5.66 -0.3 3.28e-8 Depression; CRC trans rs561341 1.000 rs521919 chr17:30298039 G/T cg27661571 chr11:113659931 NA -0.71 -8.85 -0.44 5.32e-17 Hip circumference adjusted for BMI; CRC cis rs28386778 0.799 rs2955234 chr17:61983601 A/C cg23090583 chr17:61904693 PSMC5;FTSJ3 -0.87 -14.59 -0.63 1.61e-37 Prudent dietary pattern; CRC cis rs34311866 0.808 rs748483 chr4:952409 A/G cg07828340 chr4:882639 GAK 1.08 10.08 0.49 5.16e-21 Parkinson's disease; CRC cis rs1971762 0.509 rs10783592 chr12:54037430 G/A cg06632207 chr12:54070931 ATP5G2 0.46 7.87 0.4 5.09e-14 Height; CRC cis rs7584330 0.744 rs10929235 chr2:238380272 A/G cg14458575 chr2:238380390 NA 0.9 16.34 0.67 2.4e-44 Prostate cancer; CRC cis rs708547 0.836 rs1625691 chr4:57845740 T/C cg25525207 chr4:57843836 C4orf14;POLR2B -0.58 -8.19 -0.41 5.93e-15 Response to bleomycin (chromatid breaks); CRC cis rs9905704 0.918 rs12952362 chr17:56900870 A/G cg12560992 chr17:57184187 TRIM37 0.53 7.33 0.37 1.78e-12 Testicular germ cell tumor; CRC cis rs523522 0.962 rs4767912 chr12:120981202 A/G cg12219531 chr12:120966889 COQ5 0.69 9.3 0.46 2.03e-18 High light scatter reticulocyte count; CRC cis rs6570726 0.875 rs373313 chr6:145857791 T/C cg05347473 chr6:146136440 FBXO30 0.39 6.14 0.32 2.42e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs13072153 0.793 rs9841477 chr3:123157477 A/C cg04138502 chr3:123167522 ADCY5 0.33 5.91 0.31 8.76e-9 Chronic kidney disease; CRC cis rs9611519 0.964 rs2092563 chr22:41592677 G/A cg06634786 chr22:41940651 POLR3H -0.46 -5.89 -0.31 9.41e-9 Neuroticism; CRC cis rs17539620 0.628 rs62432730 chr6:154830717 G/A cg20019720 chr6:154832845 CNKSR3 0.49 7.78 0.39 9.31e-14 Lipoprotein (a) levels; CRC cis rs7666738 0.791 rs13146909 chr4:98934198 C/T cg17366294 chr4:99064904 C4orf37 0.43 7.32 0.37 1.95e-12 Colonoscopy-negative controls vs population controls; CRC cis rs6499255 0.857 rs16959035 chr16:69707645 C/A cg15192750 chr16:69999425 NA 0.52 7.16 0.37 5.32e-12 IgE levels; CRC cis rs3101457 0.515 rs4658629 chr1:244516754 G/T cg09033006 chr1:244517177 C1orf100 -0.46 -6.56 -0.34 2.07e-10 Smoking behavior; CRC cis rs875971 0.862 rs35378740 chr7:65987712 C/A cg11764359 chr7:65958608 NA 0.59 8.81 0.44 7.57e-17 Aortic root size; CRC cis rs35306767 0.855 rs11253499 chr10:944090 A/C cg20503657 chr10:835505 NA 0.97 12.03 0.55 7.14e-28 Eosinophil percentage of granulocytes; CRC cis rs908922 0.676 rs478926 chr1:152511533 G/T cg23254163 chr1:152506842 NA 0.45 8.85 0.44 5.3e-17 Hair morphology; CRC cis rs6988985 0.728 rs5299 chr8:143955471 T/C cg10324643 chr8:143916377 GML 0.35 5.8 0.3 1.53e-8 Plasma androstenedione levels in resected early stage-receptor positive breast cancer; CRC cis rs2270875 0.736 rs79099489 chr8:132886358 T/G cg24184792 chr8:132919238 EFR3A -0.75 -6.9 -0.36 2.69e-11 Response to cholinesterase inhibitors in Alzheimer's disease; CRC cis rs13191362 0.938 rs13208970 chr6:163006368 G/T cg23758597 chr6:163146217 PARK2 -0.51 -5.91 -0.31 8.33e-9 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs1401999 1.000 rs939336 chr3:183685534 A/G cg01324343 chr3:183735012 ABCC5 0.79 14.28 0.62 2.55e-36 Anterior chamber depth; CRC cis rs3771570 1.000 rs7557535 chr2:242206555 T/C cg21155796 chr2:242212141 HDLBP 0.64 7.02 0.36 1.25e-11 Prostate cancer; CRC cis rs3771570 1.000 rs12619369 chr2:242282957 A/T cg21155796 chr2:242212141 HDLBP 0.58 6.66 0.34 1.18e-10 Prostate cancer; CRC cis rs9910055 0.762 rs11080007 chr17:42265442 A/G cg10896456 chr17:42255109 ASB16;C17orf65 -0.44 -7.05 -0.36 1.06e-11 Total body bone mineral density; CRC trans rs2727020 0.729 rs1164666 chr11:49295867 C/T cg11707556 chr5:10655725 ANKRD33B -0.36 -6.62 -0.34 1.49e-10 Coronary artery disease; CRC cis rs1865760 0.566 rs1539183 chr6:26075051 G/C cg18357526 chr6:26021779 HIST1H4A 0.43 6.08 0.32 3.26e-9 Height; CRC cis rs4332037 0.802 rs73048106 chr7:1929019 G/T cg23422044 chr7:1970798 MAD1L1 -0.63 -7.8 -0.39 8.4e-14 Bipolar disorder; CRC cis rs7274811 0.681 rs293733 chr20:31975976 C/T cg07470512 chr20:32255052 NECAB3;C20orf134 0.43 5.76 0.3 1.93e-8 Height; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg16221875 chr6:21588597 NA 0.45 6.02 0.31 4.73e-9 Thyroid stimulating hormone; CRC cis rs3820928 0.605 rs7560867 chr2:227780945 C/A cg11843606 chr2:227700838 RHBDD1 -0.47 -7.28 -0.37 2.42e-12 Pulmonary function; CRC cis rs6499255 1.000 rs73579458 chr16:69804764 G/C cg04110750 chr16:69646130 NFAT5 -0.52 -6.79 -0.35 5.3e-11 IgE levels; CRC cis rs7044106 0.762 rs1158554 chr9:123400898 G/A cg09419670 chr9:123605666 PSMD5;LOC253039 0.71 11.78 0.54 5.85e-27 Hip circumference adjusted for BMI; CRC cis rs6500602 0.679 rs736685 chr16:4508606 T/C cg08645402 chr16:4508243 NA 0.61 10.91 0.52 7.19e-24 Schizophrenia; CRC cis rs597539 0.617 rs598353 chr11:68635770 C/A cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.89 15.85 0.66 1.89e-42 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs10504229 0.728 rs59266065 chr8:58156236 A/G cg02725872 chr8:58115012 NA -0.59 -9.17 -0.45 5.24e-18 Developmental language disorder (linguistic errors); CRC cis rs9467160 0.834 rs17247566 chr6:24450404 A/C cg20631270 chr6:24437470 GPLD1 -0.48 -6.51 -0.34 2.76e-10 Liver enzyme levels; CRC trans rs1499614 1.000 rs1638731 chr7:66144679 C/T cg10756647 chr7:56101905 PSPH 0.78 8.17 0.41 6.58e-15 Gout; CRC cis rs10504073 0.584 rs4873304 chr8:49922733 G/A cg00325661 chr8:49890786 NA 0.64 11.52 0.54 5.1e-26 Blood metabolite ratios; CRC cis rs1451375 0.712 rs11974297 chr7:50618260 A/G cg18232548 chr7:50535776 DDC 0.51 7.92 0.4 3.71e-14 Malaria; CRC cis rs7493 1.000 rs1034809 chr7:95051652 G/A cg20119798 chr7:94954144 PON1 -0.51 -6.46 -0.34 3.7e-10 Yu-Zhi constitution type in type 2 diabetes; CRC trans rs2303319 0.504 rs62188990 chr2:162540635 G/A cg14875682 chr5:52083620 ITGA1;PELO -0.72 -6.0 -0.31 5.31e-9 Cognitive function; CRC cis rs7552404 0.731 rs2029683 chr1:76341643 T/G cg22875332 chr1:76189707 ACADM -0.59 -7.4 -0.38 1.15e-12 Blood metabolite levels;Acylcarnitine levels; CRC cis rs2737618 0.651 rs2816976 chr1:200081021 A/T cg21825944 chr1:200113062 NR5A2 -0.49 -7.18 -0.37 4.67e-12 Uric acid levels; CRC cis rs2243480 1.000 rs427044 chr7:65508545 G/A cg18252515 chr7:66147081 NA -1.17 -13.07 -0.58 9.77e-32 Diabetic kidney disease; CRC cis rs3741151 0.773 rs73544710 chr11:73162273 A/G cg17517138 chr11:73019481 ARHGEF17 1.04 8.44 0.42 1.01e-15 GIP levels in response to oral glucose tolerance test (120 minutes); CRC cis rs7107174 1.000 rs55825352 chr11:78034424 C/T cg02023728 chr11:77925099 USP35 0.49 7.41 0.38 1.09e-12 Testicular germ cell tumor; CRC cis rs6502050 0.835 rs28640920 chr17:80105151 A/T cg13198984 chr17:80129470 CCDC57 0.46 8.16 0.41 6.94e-15 Life satisfaction; CRC cis rs832540 0.898 rs252890 chr5:56226410 T/C cg18230493 chr5:56204884 C5orf35 -0.4 -5.91 -0.31 8.54e-9 Coronary artery disease; CRC cis rs7824557 0.564 rs2736293 chr8:11234613 T/A cg08071915 chr8:12219732 FAM66A 0.32 5.81 0.31 1.45e-8 Retinal vascular caliber; CRC cis rs7666738 0.830 rs28878289 chr4:98855181 C/T cg05340658 chr4:99064831 C4orf37 0.56 8.33 0.42 2.21e-15 Colonoscopy-negative controls vs population controls; CRC cis rs873946 0.648 rs12767283 chr10:134557094 C/G cg26818010 chr10:134567672 INPP5A -0.68 -8.5 -0.42 6.71e-16 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CRC cis rs12725198 0.507 rs41393951 chr1:16053493 C/T cg27534772 chr1:16042836 PLEKHM2 0.33 6.12 0.32 2.62e-9 Cardiac Troponin-T levels; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg26514337 chr18:57026503 LMAN1 0.37 6.01 0.31 4.83e-9 Liver disease severity in Alagille syndrome; CRC cis rs1046896 0.594 rs4075209 chr17:80800027 G/T cg02711726 chr17:80685570 FN3KRP -0.56 -7.46 -0.38 7.53e-13 Glycated hemoglobin levels; CRC cis rs6087990 0.735 rs2424906 chr20:31359109 A/G cg13636640 chr20:31349939 DNMT3B 0.79 15.35 0.65 1.81e-40 Ulcerative colitis; CRC cis rs868036 1.000 rs1471460 chr15:68089299 G/A cg05925327 chr15:68127851 NA -0.31 -6.01 -0.31 4.84e-9 Restless legs syndrome; CRC cis rs6712932 0.925 rs10210149 chr2:105839324 C/T cg22878388 chr2:105853796 NA -0.34 -6.57 -0.34 1.94e-10 Type 2 diabetes; CRC cis rs17270561 0.666 rs4711099 chr6:25741809 C/G cg17691542 chr6:26056736 HIST1H1C 0.72 9.24 0.45 3.07e-18 Iron status biomarkers; CRC cis rs4481887 1.000 rs4360555 chr1:248468591 G/T cg00666640 chr1:248458726 OR2T12 0.52 9.16 0.45 5.86e-18 Common traits (Other); CRC cis rs6951245 0.554 rs11544331 chr7:1131411 C/T cg24642844 chr7:1081250 C7orf50 -0.5 -6.44 -0.33 4.16e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs875971 0.564 rs313804 chr7:65514622 A/G cg12463550 chr7:65579703 CRCP 0.45 6.33 0.33 8.01e-10 Aortic root size; CRC cis rs2228479 0.867 rs57492102 chr16:89975572 A/G cg19635926 chr16:89946313 TCF25 0.53 5.72 0.3 2.42e-8 Skin colour saturation; CRC cis rs3820068 0.603 rs72647118 chr1:15956535 G/T cg24675056 chr1:15929824 NA 0.51 7.04 0.36 1.15e-11 Systolic blood pressure; CRC cis rs6570726 0.764 rs376257 chr6:145862949 G/A cg23711669 chr6:146136114 FBXO30 0.76 13.16 0.59 4.67e-32 Lobe attachment (rater-scored or self-reported); CRC cis rs4242434 0.927 rs3735901 chr8:22462374 T/C cg03733263 chr8:22462867 KIAA1967 1.04 20.05 0.74 5.27e-59 Exploratory eye movement dysfunction in schizophrenia (cognitive search score); CRC cis rs12995491 0.763 rs1914735 chr2:88511953 A/T cg14558114 chr2:88469736 THNSL2 -0.43 -6.25 -0.33 1.28e-9 Response to metformin (IC50); CRC cis rs7647973 0.580 rs7652746 chr3:49262307 C/T cg03060546 chr3:49711283 APEH -0.45 -6.64 -0.34 1.27e-10 Menarche (age at onset); CRC cis rs9549367 0.789 rs7338235 chr13:113888687 T/C cg00898013 chr13:113819073 PROZ -0.45 -6.63 -0.34 1.37e-10 Platelet distribution width; CRC cis rs727563 0.636 rs2413653 chr22:42106996 T/C cg06481639 chr22:41940642 POLR3H 0.53 6.06 0.32 3.66e-9 Crohn's disease;Inflammatory bowel disease; CRC cis rs3733585 0.673 rs4407505 chr4:9953367 T/G cg11266682 chr4:10021025 SLC2A9 -0.47 -9.62 -0.47 1.76e-19 Cleft plate (environmental tobacco smoke interaction); CRC cis rs12477438 0.798 rs6759354 chr2:99632195 A/G cg26064155 chr2:99771622 LIPT1;TSGA10 -0.79 -11.26 -0.53 4.29e-25 Chronic sinus infection; CRC cis rs7412746 0.634 rs12409208 chr1:150860055 A/G cg18016565 chr1:150552671 MCL1 0.41 5.75 0.3 2.01e-8 Melanoma; CRC cis rs977987 0.931 rs11641430 chr16:75495276 T/C cg03315344 chr16:75512273 CHST6 0.6 10.18 0.49 2.41e-21 Dupuytren's disease; CRC cis rs9640161 0.750 rs11538922 chr7:150035183 C/T cg13722127 chr7:150037890 RARRES2 0.47 7.23 0.37 3.44e-12 Blood protein levels;Circulating chemerin levels; CRC cis rs7772486 0.790 rs9399571 chr6:146282061 A/G cg13319975 chr6:146136371 FBXO30 0.4 6.02 0.31 4.7e-9 Lobe attachment (rater-scored or self-reported); CRC trans rs7165102 1.000 rs7163482 chr15:65739683 C/T cg22383888 chr3:27764816 EOMES -0.28 -5.99 -0.31 5.61e-9 Mean corpuscular hemoglobin; CRC cis rs6831352 0.959 rs6532796 chr4:100042242 C/T cg12011299 chr4:100065546 ADH4 -0.56 -11.65 -0.54 1.74e-26 Alcohol dependence; CRC cis rs13256369 0.760 rs7839473 chr8:8575836 C/T cg17143192 chr8:8559678 CLDN23 0.48 6.45 0.33 4.09e-10 Obesity-related traits; CRC cis rs526821 0.595 rs551665 chr11:55343268 G/A cg04317927 chr11:55418816 OR4S2 0.39 6.66 0.34 1.15e-10 Pediatric bone mineral density (spine); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg05707844 chr2:37383994 EIF2AK2 0.43 7.06 0.36 9.77e-12 Liver disease severity in Alagille syndrome; CRC trans rs2235573 0.551 rs139891 chr22:38387914 G/T cg19894588 chr14:64061835 NA 0.49 7.24 0.37 3.23e-12 Glioblastoma;Glioma; CRC cis rs6951245 1.000 rs78185558 chr7:1090183 G/C cg21664854 chr7:1097933 C7orf50;GPR146 0.73 8.53 0.43 5.52e-16 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs12594515 1.000 rs12906442 chr15:45985254 C/A cg06207120 chr15:45996521 NA 0.32 7.66 0.39 2.09e-13 Waist circumference;Weight; CRC cis rs2839186 0.564 rs4819215 chr21:47623573 G/A cg11766577 chr21:47581405 C21orf56 -0.41 -6.58 -0.34 1.89e-10 Testicular germ cell tumor; CRC cis rs453301 0.686 rs28482034 chr8:8869664 G/A cg06636001 chr8:8085503 FLJ10661 -0.5 -7.41 -0.38 1.06e-12 Joint mobility (Beighton score); CRC cis rs7617773 0.780 rs13079728 chr3:48339360 A/G cg11946769 chr3:48343235 NME6 0.76 10.24 0.49 1.55e-21 Coronary artery disease; CRC cis rs1046896 0.553 rs56775875 chr17:80831291 G/T cg19500275 chr17:80737654 TBCD 0.53 7.19 0.37 4.32e-12 Glycated hemoglobin levels; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg01539630 chr17:20946013 USP22 0.47 6.6 0.34 1.62e-10 Response to antipsychotic treatment; CRC cis rs501120 0.810 rs622472 chr10:44749211 A/C cg09554077 chr10:44749378 NA 0.91 13.53 0.6 1.87e-33 Coronary artery disease;Coronary heart disease; CRC cis rs6951245 0.706 rs28685743 chr7:1197736 C/T cg22907277 chr7:1156413 C7orf50 0.7 7.72 0.39 1.41e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs4665809 0.549 rs62130460 chr2:26472718 T/C cg27170947 chr2:26402098 FAM59B 0.66 8.08 0.41 1.24e-14 Gut microbiome composition (summer); CRC cis rs3126085 0.935 rs12726613 chr1:152185500 C/G cg09127314 chr1:152161683 NA -0.48 -5.91 -0.31 8.37e-9 Atopic dermatitis; CRC cis rs9682041 0.932 rs9841852 chr3:170067049 C/G cg11886554 chr3:170076028 SKIL 0.76 8.3 0.42 2.71e-15 Glomerular filtration rate in non diabetics (creatinine);Glomerular filtration rate (creatinine); CRC cis rs3096299 0.658 rs4785679 chr16:89566113 G/T cg00750074 chr16:89608354 SPG7 -0.52 -7.98 -0.4 2.51e-14 Multiple myeloma (IgH translocation); CRC cis rs1348850 0.567 rs2222711 chr2:178534110 G/T cg02961200 chr2:178257176 LOC100130691;AGPS 0.53 7.21 0.37 3.94e-12 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs2274273 0.588 rs58296156 chr14:55828327 C/T cg10130446 chr14:55658398 DLGAP5 -0.43 -6.03 -0.32 4.3e-9 Protein biomarker; CRC cis rs1448094 0.654 rs7133797 chr12:86294184 G/C cg18827107 chr12:86230957 RASSF9 -0.47 -7.52 -0.38 5.28e-13 Major depressive disorder; CRC trans rs7395662 0.963 rs4882094 chr11:48532460 T/C cg21153622 chr11:89784906 NA -0.45 -7.11 -0.36 7.19e-12 HDL cholesterol; CRC cis rs10870270 0.956 rs11146325 chr10:133767529 A/G cg17892150 chr10:133769511 PPP2R2D -0.75 -11.08 -0.52 1.78e-24 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; CRC cis rs17253792 0.545 rs71412688 chr14:56021539 A/G cg01858014 chr14:56050164 KTN1 -0.86 -6.65 -0.34 1.24e-10 Putamen volume; CRC cis rs1448094 0.512 rs1900701 chr12:86236231 T/C cg18827107 chr12:86230957 RASSF9 -0.46 -7.7 -0.39 1.63e-13 Major depressive disorder; CRC cis rs5750830 0.594 rs9611169 chr22:39783027 C/T cg24399712 chr22:39784796 NA -0.46 -8.95 -0.44 2.57e-17 Intelligence (multi-trait analysis); CRC cis rs12497850 0.864 rs4513485 chr3:49139966 G/A cg20833759 chr3:49053208 WDR6;DALRD3 0.44 7.21 0.37 3.91e-12 Parkinson's disease; CRC trans rs459571 0.792 rs55923934 chr9:136888233 C/G cg15028160 chr19:49622717 PPFIA3;C19orf73 -0.58 -7.32 -0.37 1.87e-12 Platelet distribution width; CRC cis rs1555322 0.530 rs2425047 chr20:33871675 G/T cg08210727 chr20:33865349 NA -0.43 -5.96 -0.31 6.57e-9 Attention deficit hyperactivity disorder; CRC cis rs4713118 0.513 rs149975 chr6:27986340 G/A cg03623178 chr6:28175578 NA 0.79 11.75 0.54 7.49e-27 Parkinson's disease; CRC trans rs10982213 0.830 rs2274163 chr9:117188714 C/T cg24515799 chr6:149867235 PPIL4 0.38 6.06 0.32 3.67e-9 Interleukin-6 levels; CRC cis rs2239547 0.618 rs2071041 chr3:52864693 T/G cg15147215 chr3:52552868 STAB1 -0.46 -7.03 -0.36 1.21e-11 Schizophrenia; CRC cis rs7786808 0.525 rs10253961 chr7:158194858 G/A cg15440763 chr7:158190612 PTPRN2 -0.4 -6.51 -0.34 2.76e-10 Obesity-related traits; CRC cis rs66887589 1.000 rs66887589 chr4:120509279 T/C cg09307838 chr4:120376055 NA -0.52 -7.84 -0.4 6.45e-14 Diastolic blood pressure; CRC cis rs11166629 1.000 rs4909332 chr8:135646340 T/C cg27224718 chr8:135614730 ZFAT 0.52 7.65 0.39 2.3e-13 Smoking quantity; CRC cis rs2019137 0.560 rs7421852 chr2:113990261 G/A cg07594247 chr2:113993304 PAX8;LOC440839;LOC654433 0.51 7.72 0.39 1.44e-13 Lymphocyte counts; CRC cis rs17767392 0.836 rs35415083 chr14:72009196 C/T cg13720639 chr14:72061746 SIPA1L1 -0.57 -7.3 -0.37 2.25e-12 Mitral valve prolapse; CRC cis rs2050392 1.000 rs2265185 chr10:30691777 A/C cg18806716 chr10:30721971 MAP3K8 -0.46 -6.78 -0.35 5.5e-11 Inflammatory bowel disease; CRC cis rs28386778 0.933 rs2665801 chr17:61952100 C/T cg06601766 chr17:61851465 DDX42;CCDC47 0.46 6.21 0.32 1.58e-9 Prudent dietary pattern; CRC cis rs6479527 0.840 rs1360429 chr9:96762314 C/T cg14459158 chr9:96720562 NA 0.41 7.57 0.39 3.86e-13 Esophageal adenocarcinoma; CRC cis rs57221529 0.766 rs72706610 chr5:561111 G/A cg09021430 chr5:549028 NA -0.73 -8.21 -0.41 5.2e-15 Lung disease severity in cystic fibrosis; CRC cis rs1799949 1.000 rs3950989 chr17:41237953 G/A cg23758822 chr17:41437982 NA 0.81 13.6 0.6 9.97e-34 Menopause (age at onset); CRC cis rs10760158 0.769 rs7870797 chr9:124060422 G/A cg14417974 chr9:124058376 GSN -0.34 -5.72 -0.3 2.41e-8 Pulse pressure; CRC cis rs6500395 0.962 rs9941275 chr16:48573428 A/G cg04672837 chr16:48644449 N4BP1 0.45 6.58 0.34 1.8e-10 Response to tocilizumab in rheumatoid arthritis; CRC cis rs7412746 0.658 rs10305704 chr1:150804429 A/C cg15448220 chr1:150897856 SETDB1 0.57 8.15 0.41 7.63e-15 Melanoma; CRC cis rs7215564 0.908 rs35363308 chr17:78687190 A/T cg09596252 chr17:78655493 RPTOR 0.56 6.15 0.32 2.22e-9 Myopia (pathological); CRC cis rs7769051 1.000 rs9493454 chr6:133144629 G/T cg22852734 chr6:133119734 C6orf192 -0.81 -9.24 -0.45 3.18e-18 Type 2 diabetes nephropathy; CRC cis rs743757 1.000 rs2282754 chr3:50436827 T/C cg08207895 chr3:50388901 TUSC4;CYB561D2 0.43 6.23 0.32 1.44e-9 Diastolic blood pressure; CRC cis rs4481887 0.927 rs4279879 chr1:248486475 A/G cg00666640 chr1:248458726 OR2T12 0.49 8.29 0.42 3.01e-15 Common traits (Other); CRC cis rs6461049 0.800 rs3778977 chr7:2159746 C/T cg04267008 chr7:1944627 MAD1L1 -0.52 -7.31 -0.37 2.06e-12 Schizophrenia; CRC cis rs8180040 0.900 rs10865946 chr3:47425060 T/G cg10298567 chr3:47292165 KIF9 -0.35 -5.83 -0.31 1.33e-8 Colorectal cancer; CRC cis rs7940866 0.903 rs11222411 chr11:130838682 A/G cg12179176 chr11:130786555 SNX19 0.56 8.25 0.41 3.76e-15 Schizophrenia; CRC cis rs929354 0.772 rs6459741 chr7:157014553 G/T cg16102536 chr7:156981717 UBE3C 0.4 6.79 0.35 5.41e-11 Body mass index; CRC cis rs7552404 0.921 rs10873685 chr1:76218818 A/C cg03433033 chr1:76189801 ACADM 0.82 11.36 0.53 1.91e-25 Blood metabolite levels;Acylcarnitine levels; CRC cis rs56235845 0.964 rs11746443 chr5:176798306 G/A cg16006841 chr5:176797999 RGS14 0.76 11.93 0.55 1.71e-27 Hemoglobin concentration;Hematocrit; CRC cis rs8099014 0.906 rs4940693 chr18:56101171 T/G cg12907477 chr18:56117327 MIR122 0.47 5.88 0.31 1.01e-8 Platelet count; CRC cis rs7312933 0.558 rs2178753 chr12:42732804 T/C cg19980929 chr12:42632907 YAF2 -0.38 -5.66 -0.3 3.24e-8 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CRC cis rs7215564 0.908 rs35434628 chr17:78714760 C/T cg09596252 chr17:78655493 RPTOR 0.53 5.62 0.3 3.98e-8 Myopia (pathological); CRC trans rs1455244 0.700 rs7229302 chr18:11508904 G/T cg01496648 chr16:67880937 CENPT;NUTF2 0.39 6.25 0.33 1.3e-9 Schizophrenia; CRC cis rs1577917 0.958 rs1447160 chr6:86546123 G/A cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.51 -6.67 -0.35 1.07e-10 Response to antipsychotic treatment; CRC cis rs896854 1.000 rs896854 chr8:95960511 T/C cg16049864 chr8:95962084 TP53INP1 -0.67 -12.39 -0.56 3.32e-29 Type 2 diabetes; CRC cis rs1552244 1.000 rs28684871 chr3:10072635 C/A cg13047869 chr3:10149882 C3orf24 0.5 6.88 0.35 3.1e-11 Alzheimer's disease; CRC trans rs3960554 0.808 rs9801125 chr7:75792451 C/T cg19862616 chr7:65841803 NCRNA00174 0.73 8.5 0.42 6.78e-16 Eotaxin levels; CRC cis rs7666738 0.791 rs7684521 chr4:99071219 A/G cg05340658 chr4:99064831 C4orf37 0.6 9.34 0.46 1.52e-18 Colonoscopy-negative controls vs population controls; CRC cis rs5753618 0.561 rs4603880 chr22:31744721 T/C cg07713946 chr22:31675144 LIMK2 0.39 5.69 0.3 2.75e-8 Colorectal cancer; CRC cis rs1005277 0.541 rs1740741 chr10:38515334 C/T cg00409905 chr10:38381863 ZNF37A -0.62 -10.29 -0.49 1.04e-21 Extrinsic epigenetic age acceleration; CRC cis rs7584330 0.518 rs74003103 chr2:238446699 G/A cg14458575 chr2:238380390 NA 0.69 8.61 0.43 3.04e-16 Prostate cancer; CRC cis rs3760982 1.000 rs60184524 chr19:44294215 A/G cg12072164 chr19:44306565 LYPD5 0.41 6.47 0.34 3.58e-10 Breast cancer (estrogen-receptor negative);Breast cancer; CRC cis rs6088580 0.634 rs6088488 chr20:32992631 T/C cg24642439 chr20:33292090 TP53INP2 -0.38 -6.41 -0.33 5.08e-10 Glomerular filtration rate (creatinine); CRC cis rs56399783 0.614 rs11765492 chr7:2771642 G/A cg19731401 chr7:2775893 GNA12 0.63 6.64 0.34 1.3100000000000001e-10 Childhood ear infection; CRC cis rs597539 0.690 rs11228383 chr11:68623228 T/G cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.85 13.59 0.6 1.05e-33 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs7618915 0.501 rs11130308 chr3:52639257 G/C cg08222913 chr3:52553049 STAB1 -0.34 -6.35 -0.33 7.03e-10 Bipolar disorder; CRC cis rs6088590 0.901 rs6087631 chr20:33403509 T/C cg08999081 chr20:33150536 PIGU 0.52 8.85 0.44 5.57e-17 Coronary artery disease; CRC cis rs7647973 0.626 rs9829155 chr3:49817450 T/C cg13072238 chr3:49761600 GMPPB 0.48 5.63 0.3 3.86e-8 Menarche (age at onset); CRC cis rs17023223 0.537 rs6677107 chr1:119708765 C/T cg05756136 chr1:119680316 WARS2 -0.52 -7.14 -0.37 6e-12 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for BMI in active individuals; CRC cis rs34779708 0.931 rs4934709 chr10:35339324 A/C cg03585969 chr10:35415529 CREM -0.64 -8.69 -0.43 1.68e-16 Inflammatory bowel disease;Crohn's disease; CRC cis rs2762353 0.574 rs34067542 chr6:25728210 T/A cg15691649 chr6:25882328 NA 0.49 6.41 0.33 5.05e-10 Blood metabolite levels; CRC cis rs2011503 0.882 rs72999030 chr19:19364240 A/T cg11584989 chr19:19387371 SF4 0.48 5.99 0.31 5.51e-9 Bipolar disorder; CRC cis rs62432291 0.764 rs436743 chr6:159655102 A/G cg14500486 chr6:159655392 FNDC1 -0.76 -10.4 -0.5 4.17e-22 Joint mobility (Beighton score); CRC cis rs2032447 0.802 rs199755 chr6:25990367 G/A cg03264133 chr6:25882463 NA -0.54 -7.44 -0.38 8.91e-13 Intelligence (multi-trait analysis); CRC cis rs1538970 1.000 rs17395553 chr1:45864761 C/T cg05343316 chr1:45956843 TESK2 0.71 9.83 0.48 3.72e-20 Platelet count; CRC cis rs13427251 0.903 rs6746402 chr2:100150443 G/A cg26064155 chr2:99771622 LIPT1;TSGA10 -0.5 -7.17 -0.37 5.01e-12 Chronic sinus infection; CRC cis rs7586673 1.000 rs7586673 chr2:161923520 C/A cg22496339 chr2:162101262 NA 0.56 7.91 0.4 3.98e-14 Intelligence (multi-trait analysis); CRC cis rs7208859 0.623 rs73267858 chr17:29059737 A/G cg13385521 chr17:29058706 SUZ12P 0.7 7.85 0.4 5.96e-14 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg18002896 chr8:144465845 RHPN1 0.44 7.31 0.37 2.1e-12 Liver disease severity in Alagille syndrome; CRC cis rs2535633 0.631 rs2581827 chr3:52966558 C/T cg11645453 chr3:52864694 ITIH4 -0.4 -7.44 -0.38 8.7e-13 Body mass index; CRC trans rs10838798 0.504 rs1483123 chr11:48326773 G/A cg15704280 chr7:45808275 SEPT13 -0.48 -6.88 -0.35 3.05e-11 Height; CRC cis rs300703 0.576 rs3791216 chr2:237142 C/A cg21211680 chr2:198530 NA 0.98 8.49 0.42 7.39e-16 Blood protein levels; CRC cis rs737337 0.623 rs17699089 chr19:11343795 A/G cg00586551 chr19:11347513 LOC55908;DOCK6 0.82 9.38 0.46 1.13e-18 HDL cholesterol;HDL cholesterol levels; CRC cis rs2276314 0.857 rs28435069 chr18:33628475 A/G cg05985134 chr18:33552581 C18orf21 0.5 7.04 0.36 1.14e-11 Endometriosis;Drug-induced torsades de pointes; CRC cis rs2576037 0.899 rs2060417 chr18:44576486 C/A cg24750912 chr18:44543259 TCEB3CL;KATNAL2 -0.29 -5.61 -0.3 4.23e-8 Personality dimensions; CRC cis rs644799 0.710 rs56384142 chr11:95502075 G/T cg03916912 chr11:95522834 CEP57;FAM76B 0.86 15.59 0.65 2.1e-41 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs6540556 0.769 rs6679405 chr1:209926468 A/C cg23920097 chr1:209922102 NA -0.52 -6.48 -0.34 3.27e-10 Red blood cell count; CRC cis rs561341 1.000 rs72823787 chr17:30283809 A/T cg12193833 chr17:30244370 NA -0.75 -8.72 -0.43 1.4e-16 Hip circumference adjusted for BMI; CRC cis rs12681288 0.676 rs1562921 chr8:1021986 G/T cg15309053 chr8:964076 NA 0.42 7.06 0.36 1.02e-11 Schizophrenia; CRC cis rs3096299 0.685 rs4785568 chr16:89553707 A/G cg00750074 chr16:89608354 SPG7 -0.44 -6.62 -0.34 1.47e-10 Multiple myeloma (IgH translocation); CRC cis rs7618501 0.633 rs4688690 chr3:50022292 G/A cg24110177 chr3:50126178 RBM5 -0.47 -7.02 -0.36 1.26e-11 Intelligence (multi-trait analysis); CRC cis rs2075371 0.897 rs1643102 chr7:133999983 T/A cg20476274 chr7:133979776 SLC35B4 0.79 14.13 0.61 9.31e-36 Mean platelet volume; CRC cis rs155076 0.711 rs4770129 chr13:21882059 T/G cg21970626 chr13:21893289 NA -0.44 -6.59 -0.34 1.8e-10 White matter hyperintensity burden; CRC cis rs736408 0.609 rs13061423 chr3:52790213 T/C cg11645453 chr3:52864694 ITIH4 0.35 6.11 0.32 2.81e-9 Bipolar disorder; CRC cis rs4665809 0.652 rs6728090 chr2:26524726 C/T cg22920501 chr2:26401640 FAM59B -0.59 -8.46 -0.42 9.2e-16 Gut microbiome composition (summer); CRC cis rs9467773 0.595 rs9366657 chr6:26434914 C/G cg09904177 chr6:26538194 HMGN4 0.42 5.88 0.31 9.88e-9 Intelligence (multi-trait analysis); CRC cis rs12931792 0.712 rs56399904 chr16:30166183 C/T cg17640201 chr16:30407289 ZNF48 0.41 5.87 0.31 1.09e-8 Tonsillectomy; CRC cis rs172166 0.515 rs2622320 chr6:28115336 T/A cg12172441 chr6:28176163 NA 0.45 6.55 0.34 2.16e-10 Cardiac Troponin-T levels; CRC cis rs67478160 0.643 rs12878868 chr14:104233725 G/A cg01849466 chr14:104193079 ZFYVE21 -0.5 -9.0 -0.44 1.84e-17 Schizophrenia; CRC cis rs1395 0.778 rs6709602 chr2:27405497 C/T cg14242246 chr2:27434262 C2orf28;SLC5A6 0.41 7.44 0.38 9e-13 Blood metabolite levels; CRC cis rs561341 1.000 rs501957 chr17:30314504 C/T cg12193833 chr17:30244370 NA -0.72 -8.54 -0.43 5.04e-16 Hip circumference adjusted for BMI; CRC cis rs7216064 0.953 rs4791300 chr17:65930772 A/G cg12091567 chr17:66097778 LOC651250 -0.63 -8.05 -0.41 1.55e-14 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CRC cis rs2404602 1.000 rs6495206 chr15:76870963 C/T cg22467129 chr15:76604101 ETFA -0.38 -6.39 -0.33 5.62e-10 Blood metabolite levels; CRC cis rs9486715 0.867 rs4839842 chr6:96955387 A/T cg06623918 chr6:96969491 KIAA0776 1.02 20.45 0.75 1.42e-60 Headache; CRC cis rs4666002 0.956 rs10169065 chr2:27778560 A/G cg27432699 chr2:27873401 GPN1 0.45 5.87 0.31 1.05e-8 Phospholipid levels (plasma); CRC cis rs7552404 1.000 rs4646961 chr1:76217169 G/A cg10523679 chr1:76189770 ACADM 0.86 11.82 0.55 3.99e-27 Blood metabolite levels;Acylcarnitine levels; CRC cis rs9399135 0.967 rs6910530 chr6:135332770 C/T cg24558204 chr6:135376177 HBS1L 0.52 8.21 0.41 4.97e-15 Red blood cell count; CRC cis rs10262624 0.528 rs722294 chr7:23746585 A/C cg20363699 chr7:23626180 CLK2P 0.35 6.26 0.33 1.17e-9 Schizophrenia; CRC cis rs10504229 0.645 rs6995814 chr8:58114159 C/T cg02290350 chr8:58132656 NA -0.58 -8.24 -0.41 4.09e-15 Developmental language disorder (linguistic errors); CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg16471084 chr6:11537861 TMEM170B -0.4 -6.46 -0.34 3.77e-10 Myopia (pathological); CRC cis rs1448094 0.511 rs56291271 chr12:86162287 G/A cg18827107 chr12:86230957 RASSF9 -0.37 -5.73 -0.3 2.23e-8 Major depressive disorder; CRC cis rs2249625 0.523 rs1969530 chr6:72861276 A/C cg18830697 chr6:72922368 RIMS1 -0.31 -6.19 -0.32 1.8e-9 Acute urticaria and angioedema (non-steroidal anti-inflammatory drug-induced); CRC cis rs10504229 0.683 rs6980850 chr8:58127204 A/G cg02725872 chr8:58115012 NA -0.64 -11.55 -0.54 3.85e-26 Developmental language disorder (linguistic errors); CRC cis rs365302 0.767 rs413952 chr6:159612661 A/G cg14500486 chr6:159655392 FNDC1 0.59 8.57 0.43 4.21e-16 Coronary heart disease; CRC cis rs4804416 1.000 rs4804416 chr19:7223848 G/T cg00428638 chr19:7224713 INSR -0.6 -9.89 -0.48 2.35e-20 Thyroid hormone levels;Hypothyroidism; CRC cis rs6502050 0.871 rs6502055 chr17:80070868 G/T cg22110888 chr17:80059540 CCDC57 -0.42 -6.43 -0.33 4.51e-10 Life satisfaction; CRC cis rs9527 0.590 rs10786741 chr10:104939182 G/A cg15744005 chr10:104629667 AS3MT -0.32 -6.21 -0.32 1.56e-9 Arsenic metabolism; CRC cis rs769267 0.965 rs2315281 chr19:19480099 G/A cg03709012 chr19:19516395 GATAD2A -0.73 -11.35 -0.53 1.97e-25 Tonsillectomy; CRC cis rs1881797 1.000 rs10925062 chr1:247658978 G/C cg18198730 chr1:247681584 NA 0.57 8.44 0.42 1.03e-15 Acute lymphoblastic leukemia (childhood); CRC cis rs12541635 0.966 rs55729609 chr8:107056034 A/C cg10147462 chr8:107024639 NA 0.47 7.82 0.4 7.24e-14 Age of smoking initiation; CRC cis rs6918586 0.636 rs198857 chr6:26102417 G/C cg18357526 chr6:26021779 HIST1H4A -0.49 -7.4 -0.38 1.16e-12 Schizophrenia; CRC cis rs853679 0.517 rs9366715 chr6:28064633 A/G cg12172441 chr6:28176163 NA 0.62 7.33 0.37 1.76e-12 Depression; CRC cis rs394563 0.591 rs237018 chr6:149743930 A/G cg11245181 chr6:149772854 ZC3H12D -0.55 -9.85 -0.48 3.24e-20 Dupuytren's disease; CRC cis rs501120 0.810 rs683297 chr10:44746140 A/G cg09554077 chr10:44749378 NA 0.9 13.3 0.59 1.4e-32 Coronary artery disease;Coronary heart disease; CRC cis rs1552244 0.832 rs73024591 chr3:10203194 A/T cg13047869 chr3:10149882 C3orf24 0.52 6.13 0.32 2.48e-9 Alzheimer's disease; CRC cis rs12410462 0.792 rs994666 chr1:227651454 C/T cg23173402 chr1:227635558 NA -0.6 -7.01 -0.36 1.35e-11 Major depressive disorder; CRC cis rs1528435 1.000 rs11690655 chr2:181519434 C/T cg23363182 chr2:181467187 NA -0.35 -5.69 -0.3 2.82e-8 Body mass index; CRC cis rs9462027 0.628 rs2814945 chr6:34647978 G/A cg07306190 chr6:34760872 UHRF1BP1 -0.35 -6.32 -0.33 8.5e-10 Systemic lupus erythematosus; CRC cis rs2032447 0.901 rs1540276 chr6:26028819 T/G cg03517284 chr6:25882590 NA -0.51 -6.9 -0.36 2.62e-11 Intelligence (multi-trait analysis); CRC cis rs2153535 0.580 rs9328483 chr6:8521295 A/G cg21535247 chr6:8435926 SLC35B3 0.47 7.33 0.37 1.83e-12 Motion sickness; CRC cis rs751728 1.000 rs9380378 chr6:33765479 T/C cg25922239 chr6:33757077 LEMD2 0.6 9.3 0.46 1.99e-18 Crohn's disease; CRC cis rs9891119 0.576 rs8069645 chr17:40494902 C/T cg06270615 chr17:40516068 STAT3 0.34 7.03 0.36 1.24e-11 Multiple sclerosis;Crohn's disease; CRC cis rs9467711 0.606 rs9358935 chr6:26369587 A/G cg14345882 chr6:26364793 BTN3A2 0.65 5.74 0.3 2.17e-8 Autism spectrum disorder or schizophrenia; CRC cis rs763014 1.000 rs2269558 chr16:682250 C/T cg04562611 chr16:615315 C16orf11 0.36 6.0 0.31 5.3300000000000004e-09 Height; CRC cis rs6424115 0.830 rs3003333 chr1:24194014 A/T cg15997130 chr1:24165203 NA -0.73 -11.4 -0.53 1.4e-25 Immature fraction of reticulocytes; CRC cis rs1552244 0.935 rs4441636 chr3:10083876 G/A cg10729496 chr3:10149963 C3orf24 0.54 6.98 0.36 1.65e-11 Alzheimer's disease; CRC cis rs4654899 0.643 rs651538 chr1:21097866 A/G cg02927042 chr1:21476669 EIF4G3 -0.37 -5.84 -0.31 1.29e-8 Superior frontal gyrus grey matter volume; CRC cis rs9322193 0.926 rs9285525 chr6:150122389 C/G cg07701084 chr6:150067640 NUP43 0.47 6.61 0.34 1.51e-10 Lung cancer; CRC cis rs148387471 1 rs148387471 chr3:127057551 ATAG/A cg27326032 chr3:127006922 NA -0.55 -7.28 -0.37 2.48e-12 Interleukin-10 levels;Interleukin-13 levels; CRC cis rs7208859 0.673 rs78799101 chr17:29215160 A/T cg01831904 chr17:28903510 LRRC37B2 -0.54 -5.73 -0.3 2.25e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs3736485 0.966 rs11070854 chr15:51808365 A/G cg08986416 chr15:51914746 DMXL2 -0.45 -6.3 -0.33 9.47e-10 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs9326248 1.000 rs585849 chr11:117069061 A/G cg15534755 chr11:117069859 TAGLN 0.35 6.65 0.34 1.22e-10 Blood protein levels; CRC cis rs2658782 0.756 rs3019205 chr11:93109553 A/G cg15737290 chr11:93063684 CCDC67 0.48 6.94 0.36 2.06e-11 Pulmonary function decline; CRC cis rs2439831 0.850 rs28696802 chr15:44140395 T/C cg02155558 chr15:43621948 ADAL;LCMT2 0.65 7.16 0.37 5.44e-12 Lung cancer in ever smokers; CRC cis rs6880778 0.505 rs10473189 chr5:40402692 G/C cg09067459 chr5:40385259 NA 0.46 7.9 0.4 4.18e-14 Inflammatory bowel disease; CRC cis rs1223397 1.000 rs1232392 chr6:13272671 C/G cg21538684 chr6:13274180 PHACTR1 0.47 5.82 0.31 1.41e-8 Blood pressure; CRC cis rs79387448 0.626 rs80277428 chr2:103080056 G/A cg00507830 chr2:103233733 NA 0.67 6.35 0.33 7.17e-10 Gut microbiota (bacterial taxa); CRC cis rs9733 0.596 rs2867304 chr1:150630995 G/A cg10589385 chr1:150898437 SETDB1 0.28 5.98 0.31 5.86e-9 Tonsillectomy; CRC cis rs3771570 0.901 rs4675969 chr2:242217627 C/T cg21155796 chr2:242212141 HDLBP 0.57 6.74 0.35 6.92e-11 Prostate cancer; CRC cis rs11098499 0.954 rs12499324 chr4:120393786 C/T cg24375607 chr4:120327624 NA 0.49 7.51 0.38 5.68e-13 Corneal astigmatism; CRC cis rs1528435 1.000 rs2887185 chr2:181528597 C/A cg23363182 chr2:181467187 NA -0.35 -5.67 -0.3 3.14e-8 Body mass index; CRC cis rs6504622 0.818 rs9912794 chr17:45034441 C/T cg16759221 chr17:45003025 GOSR2 -0.49 -7.4 -0.38 1.13e-12 Orofacial clefts; CRC cis rs13191362 0.507 rs2510207 chr6:163086592 T/C cg06582575 chr6:163149167 PACRG;PARK2 -0.55 -8.31 -0.42 2.52e-15 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs1218582 0.596 rs906595 chr1:154822907 C/T cg06221963 chr1:154839813 KCNN3 -0.56 -9.08 -0.45 1.06e-17 Prostate cancer; CRC cis rs910316 0.967 rs12147532 chr14:75651858 T/G cg03030879 chr14:75389066 RPS6KL1 0.43 6.45 0.34 4e-10 Height; CRC cis rs7512552 0.809 rs2794679 chr1:150324857 G/A cg15654264 chr1:150340011 RPRD2 0.59 8.59 0.43 3.42e-16 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); CRC cis rs2742417 0.603 rs7631818 chr3:45775931 A/T cg04837898 chr3:45731254 SACM1L -0.48 -7.69 -0.39 1.74e-13 Response to anti-depressant treatment in major depressive disorder; CRC cis rs425277 0.585 rs364677 chr1:2071765 A/G cg04315214 chr1:2043799 PRKCZ 0.38 6.7 0.35 9.25e-11 Height; CRC trans rs7829975 0.711 rs4841051 chr8:8685646 C/T cg16141378 chr3:129829833 LOC729375 0.39 6.11 0.32 2.89e-9 Mood instability; CRC cis rs6570726 0.935 rs386344 chr6:145855622 A/G cg05347473 chr6:146136440 FBXO30 0.38 6.08 0.32 3.4e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs651907 0.557 rs11924013 chr3:101366698 G/A cg11279151 chr3:101281821 RG9MTD1 -0.51 -7.02 -0.36 1.29e-11 Colorectal cancer; CRC cis rs2739330 0.760 rs5760095 chr22:24247293 A/G cg15242686 chr22:24348715 GSTTP1 0.45 6.73 0.35 7.47e-11 Liver enzyme levels (gamma-glutamyl transferase); CRC trans rs2303319 0.504 rs56965753 chr2:162597251 A/G cg25193742 chr10:104614220 C10orf32 -0.77 -6.51 -0.34 2.87e-10 Cognitive function; CRC cis rs2180341 0.883 rs6904630 chr6:127696869 A/G cg27446573 chr6:127587934 RNF146 0.98 13.85 0.61 1.08e-34 Breast cancer; CRC cis rs7552404 1.000 rs9662166 chr1:76235906 C/A cg22875332 chr1:76189707 ACADM 0.64 8.63 0.43 2.58e-16 Blood metabolite levels;Acylcarnitine levels; CRC cis rs9486715 1.000 rs11153082 chr6:97059666 A/G cg18709589 chr6:96969512 KIAA0776 -0.55 -8.07 -0.41 1.34e-14 Headache; CRC cis rs1023500 0.505 rs134886 chr22:42673856 C/T cg15557168 chr22:42548783 NA 0.39 6.7 0.35 8.79e-11 Schizophrenia; CRC cis rs875971 0.830 rs778711 chr7:65851657 G/A cg11764359 chr7:65958608 NA 0.57 8.44 0.42 1.01e-15 Aortic root size; CRC cis rs2836974 0.897 rs8132419 chr21:40527827 C/T cg11890956 chr21:40555474 PSMG1 1.1 21.14 0.76 3.07e-63 Cognitive function; CRC cis rs875971 0.540 rs35510581 chr7:65578777 G/A cg18876405 chr7:65276391 NA -0.61 -10.92 -0.52 6.78e-24 Aortic root size; CRC trans rs2727020 0.658 rs4980431 chr11:49350071 G/T cg03929089 chr4:120376271 NA -0.82 -14.56 -0.63 2e-37 Coronary artery disease; CRC cis rs2549003 1.000 rs2548997 chr5:131835395 C/T cg21138405 chr5:131827807 IRF1 -0.58 -11.35 -0.53 2.12e-25 Asthma (sex interaction); CRC cis rs6460942 0.630 rs17670901 chr7:12386622 G/A cg20607287 chr7:12443886 VWDE -0.58 -6.16 -0.32 2.07e-9 Coronary artery disease; CRC cis rs3806843 1.000 rs10037757 chr5:140197222 G/T cg16607685 chr5:140181889 PCDHA2;PCDHA1;PCDHA3 -0.26 -6.01 -0.31 4.84e-9 Depressive symptoms (multi-trait analysis); CRC cis rs910316 0.810 rs77939209 chr14:75670070 A/G cg08847533 chr14:75593920 NEK9 -0.82 -13.66 -0.6 6.03e-34 Height; CRC cis rs6500602 0.627 rs4786494 chr16:4506232 G/A cg08645402 chr16:4508243 NA 0.59 9.14 0.45 6.67e-18 Schizophrenia; CRC cis rs4332037 0.539 rs1533827 chr7:2074290 A/G cg13880726 chr7:1868755 MAD1L1 0.45 5.76 0.3 1.89e-8 Bipolar disorder; CRC cis rs7617773 0.817 rs936426 chr3:48215253 C/T cg11946769 chr3:48343235 NME6 0.63 8.76 0.43 1.05e-16 Coronary artery disease; CRC cis rs801193 0.548 rs2109297 chr7:66122384 G/A cg18876405 chr7:65276391 NA -0.5 -8.05 -0.41 1.5e-14 Aortic root size; CRC cis rs427941 0.655 rs201472 chr7:101744428 C/T cg06246474 chr7:101738831 CUX1 0.44 6.7 0.35 8.96e-11 Plasma omega-3 polyunsaturated fatty acid level (eicosapentaenoic acid); CRC cis rs2243480 1.000 rs422164 chr7:65586605 C/G cg12463550 chr7:65579703 CRCP 0.68 6.34 0.33 7.74e-10 Diabetic kidney disease; CRC cis rs7917772 0.503 rs2031602 chr10:104307955 G/C cg22532475 chr10:104410764 TRIM8 -0.37 -6.95 -0.36 1.99e-11 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC cis rs10751667 0.643 rs10902257 chr11:973577 T/C cg23136738 chr11:925521 AP2A2 -0.42 -7.09 -0.36 8.01e-12 Alzheimer's disease (late onset); CRC cis rs780096 0.526 rs780107 chr2:27684734 A/G cg24768116 chr2:27665128 KRTCAP3 -0.36 -8.12 -0.41 9.76e-15 Total body bone mineral density; CRC cis rs6540559 1.000 rs7522250 chr1:209962539 T/C cg25204440 chr1:209979598 IRF6 0.48 6.32 0.33 8.69e-10 Cleft lip with or without cleft palate; CRC cis rs9322193 0.847 rs4870054 chr6:150169538 C/T cg13206674 chr6:150067644 NUP43 0.68 9.66 0.47 1.36e-19 Lung cancer; CRC cis rs2243480 1.000 rs6958289 chr7:65657111 T/G cg12463550 chr7:65579703 CRCP -0.73 -6.56 -0.34 2.1e-10 Diabetic kidney disease; CRC cis rs2976388 0.578 rs13254358 chr8:143823876 G/A cg12516270 chr8:143859308 LYNX1 -0.4 -6.23 -0.32 1.46e-9 Urinary tract infection frequency; CRC cis rs4824093 0.610 rs9627798 chr22:50317857 G/A cg22709217 chr22:50311962 ALG12;CRELD2 -0.94 -8.7 -0.43 1.57e-16 Amyotrophic lateral sclerosis (sporadic); CRC cis rs7605827 0.930 rs6749063 chr2:15565278 T/G cg19274914 chr2:15703543 NA 0.39 5.96 0.31 6.62e-9 Educational attainment (years of education); CRC cis rs6076065 0.748 rs4142246 chr20:23388975 A/G cg11657817 chr20:23433608 CST11 0.51 8.68 0.43 1.88e-16 Facial morphology (factor 15, philtrum width); CRC trans rs2303319 0.504 rs66761688 chr2:162578911 T/C cg18122310 chr12:50236657 BCDIN3D -0.73 -6.13 -0.32 2.5e-9 Cognitive function; CRC trans rs2303319 0.504 rs56100249 chr2:162415157 T/C cg12500891 chr11:57225987 NA -0.67 -5.99 -0.31 5.59e-9 Cognitive function; CRC cis rs9322193 0.639 rs4869756 chr6:150207496 G/A cg07701084 chr6:150067640 NUP43 0.47 5.78 0.3 1.73e-8 Lung cancer; CRC cis rs2839186 0.559 rs2277826 chr21:47639492 C/G cg09417038 chr21:47716443 C21orf57 0.38 6.26 0.33 1.17e-9 Testicular germ cell tumor; CRC cis rs9457247 0.765 rs6904946 chr6:167433948 C/T cg07741184 chr6:167504864 NA -0.38 -6.72 -0.35 8.08e-11 Crohn's disease; CRC cis rs6479527 0.840 rs1331218 chr9:96766421 T/C cg14459158 chr9:96720562 NA 0.38 6.99 0.36 1.51e-11 Esophageal adenocarcinoma; CRC cis rs8077889 0.956 rs58242860 chr17:41847300 T/C cg16892393 chr17:41919603 NA 0.39 5.9 0.31 8.88e-9 Triglycerides; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg00043095 chr2:223289277 SGPP2 0.39 6.35 0.33 7.14e-10 Liver disease severity in Alagille syndrome; CRC cis rs12188164 0.620 rs56070387 chr5:482531 A/T cg21625146 chr5:486483 SLC9A3 -0.47 -5.72 -0.3 2.35e-8 Cystic fibrosis severity; CRC cis rs2832191 0.636 rs8131283 chr21:30516796 A/G cg08807101 chr21:30365312 RNF160 -0.53 -7.31 -0.37 2.02e-12 Dental caries; CRC cis rs2976388 0.609 rs2376491 chr8:143790934 G/A cg05569086 chr8:143859399 LYNX1 0.37 6.59 0.34 1.76e-10 Urinary tract infection frequency; CRC trans rs3942852 0.806 rs4752893 chr11:48118604 C/T cg15704280 chr7:45808275 SEPT13 -0.61 -7.87 -0.4 5.35e-14 Acute lymphoblastic leukemia (childhood); CRC cis rs17490626 0.533 rs12771890 chr10:71189483 T/A cg12610070 chr10:71211762 TSPAN15 -0.42 -7.28 -0.37 2.52e-12 Thrombosis; CRC trans rs10202249 0.716 rs75322913 chr2:154081080 G/A cg25823578 chr14:52781312 PTGER2 -0.56 -6.0 -0.31 5.2e-9 Conotruncal heart defects (inherited effects); CRC trans rs8108034 1.000 rs39587 chr19:39806997 C/T cg12564526 chr7:66767603 PMS2L4;STAG3L4 -0.55 -6.03 -0.32 4.29e-9 Lung adenocarcinoma; CRC cis rs910316 0.575 rs12889133 chr14:75465089 C/T cg11812906 chr14:75593930 NEK9 0.51 6.96 0.36 1.84e-11 Height; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg05881034 chr3:42623675 SEC22C -0.42 -6.22 -0.32 1.48e-9 Myopia (pathological); CRC cis rs7615952 0.688 rs12485622 chr3:125710739 T/C cg15145296 chr3:125709740 NA -0.56 -6.79 -0.35 5.37e-11 Blood pressure (smoking interaction); CRC cis rs2836754 1.000 rs11701117 chr21:40292512 C/T cg16734191 chr21:40194848 ETS2 -0.32 -5.65 -0.3 3.53e-8 Crohn's disease;Body mass index; CRC trans rs587242 1.000 rs661573 chr1:96891371 G/A cg10631902 chr5:14652156 NA 0.45 7.06 0.36 1.02e-11 Body mass index (joint analysis main effects and physical activity interaction);Body mass index in physically inactive individuals;Body mass index; CRC cis rs1448094 0.549 rs12308898 chr12:86233678 G/A cg18827107 chr12:86230957 RASSF9 -0.49 -8.01 -0.4 1.98e-14 Major depressive disorder; CRC cis rs9902453 1.000 rs12600993 chr17:28291222 T/A cg26525008 chr17:28256777 EFCAB5;SSH2 0.58 8.83 0.44 6.44e-17 Coffee consumption (cups per day); CRC cis rs2243480 1.000 rs73150014 chr7:65450919 A/C cg18252515 chr7:66147081 NA -1.05 -12.05 -0.55 6.18e-28 Diabetic kidney disease; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg24166786 chr3:124775112 HEG1 0.43 6.26 0.33 1.17e-9 Intelligence (multi-trait analysis); CRC cis rs7914558 1.000 rs7896547 chr10:104866958 A/G cg04362960 chr10:104952993 NT5C2 0.59 8.89 0.44 3.96e-17 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs4919694 0.536 rs12414777 chr10:104697781 C/T cg04362960 chr10:104952993 NT5C2 0.73 8.69 0.43 1.8e-16 Arsenic metabolism; CRC cis rs4727027 0.754 rs11764892 chr7:148858916 G/A cg23583168 chr7:148888333 NA -0.8 -12.02 -0.55 7.5e-28 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC cis rs6460942 0.591 rs62448733 chr7:12350526 C/T cg20607287 chr7:12443886 VWDE -0.54 -6.05 -0.32 3.89e-9 Coronary artery disease; CRC cis rs875971 0.638 rs6460305 chr7:66060408 G/A cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.43 -6.32 -0.33 8.42e-10 Aortic root size; CRC cis rs10479542 0.784 rs6896940 chr5:178985994 G/C cg21226059 chr5:178986404 RUFY1 0.41 7.48 0.38 7.04e-13 Lung cancer; CRC cis rs6450176 0.597 rs1541682 chr5:53304401 C/T cg22592108 chr5:53304441 ARL15 0.53 6.24 0.33 1.32e-9 HDL cholesterol levels;HDL cholesterol;Adiponectin levels; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg11056435 chr2:69969221 ANXA4 0.45 6.12 0.32 2.59e-9 Response to antipsychotic treatment; CRC cis rs1153858 1.000 rs1346268 chr15:45673029 T/C cg10760299 chr15:45669010 GATM 0.5 7.82 0.4 7.18e-14 Homoarginine levels; CRC cis rs4665809 0.590 rs3806515 chr2:26466975 C/T cg26119090 chr2:26468346 HADHA;HADHB 1.06 15.5 0.65 4.69e-41 Gut microbiome composition (summer); CRC cis rs8060686 0.841 rs56374641 chr16:67908713 G/T cg04539111 chr16:67997858 SLC12A4 -0.48 -5.68 -0.3 2.92e-8 HDL cholesterol;Metabolic syndrome; CRC cis rs4588572 0.643 rs1560195 chr5:77701913 A/G cg11446398 chr5:77624930 NA -0.48 -6.72 -0.35 7.94e-11 Triglycerides; CRC cis rs2153535 0.580 rs2327053 chr6:8443127 A/G cg21535247 chr6:8435926 SLC35B3 0.49 7.33 0.37 1.83e-12 Motion sickness; CRC cis rs7772486 0.754 rs702323 chr6:146008274 A/G cg23711669 chr6:146136114 FBXO30 -0.63 -10.23 -0.49 1.67e-21 Lobe attachment (rater-scored or self-reported); CRC cis rs4713118 0.586 rs6905522 chr6:28086479 A/C cg15786705 chr6:28176104 NA 0.76 9.47 0.46 5.57e-19 Parkinson's disease; CRC cis rs2404602 0.692 rs4641709 chr15:77047736 C/T cg03037974 chr15:76606532 NA -0.66 -11.16 -0.52 9.99e-25 Blood metabolite levels; CRC cis rs3540 0.512 rs8033595 chr15:91083353 G/A cg22089800 chr15:90895588 ZNF774 -0.59 -9.88 -0.48 2.53e-20 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; CRC cis rs8062405 0.723 rs4788079 chr16:28559363 C/A cg05139728 chr16:28306816 SBK1 -0.37 -5.99 -0.31 5.4e-9 Cognitive ability (multi-trait analysis);Cognitive ability; CRC cis rs7591163 0.959 rs10933217 chr2:228716226 T/C cg20647610 chr2:228736258 WDR69 -0.5 -6.8 -0.35 4.83e-11 Blood pressure; CRC trans rs11098499 0.691 rs10010355 chr4:120261043 A/G cg25214090 chr10:38739885 LOC399744 0.55 9.02 0.45 1.61e-17 Corneal astigmatism; CRC cis rs9487051 1.000 rs9374080 chr6:109616420 C/T cg21918786 chr6:109611834 NA 0.38 6.64 0.34 1.29e-10 Reticulocyte fraction of red cells; CRC cis rs2153535 0.580 rs1577466 chr6:8444192 T/C cg07606381 chr6:8435919 SLC35B3 0.67 10.68 0.51 4.61e-23 Motion sickness; CRC cis rs9311676 0.632 rs11130631 chr3:58366128 G/C cg06643156 chr3:58380774 PXK 0.42 6.55 0.34 2.17e-10 Systemic lupus erythematosus; CRC trans rs11581859 0.950 rs10489918 chr1:99389462 A/T cg12183875 chr3:169587454 LRRC31 0.28 6.33 0.33 7.89e-10 Response to cognitive-behavioural therapy in anxiety disorder; CRC cis rs1046896 1.000 rs1046875 chr17:80685426 A/G cg08200770 chr17:80723486 TBCD 0.42 7.15 0.37 5.63e-12 Glycated hemoglobin levels; CRC cis rs17433780 0.928 rs12127787 chr1:89458761 T/C cg09516651 chr1:89888402 LOC400759 0.46 6.78 0.35 5.55e-11 Carotid intima media thickness; CRC cis rs4880487 0.853 rs883490 chr10:1249567 G/C cg03183215 chr10:1252341 ADARB2 -0.3 -6.35 -0.33 7.02e-10 Migraine; CRC cis rs9916302 0.904 rs7501488 chr17:37576417 T/G cg15445000 chr17:37608096 MED1 0.43 9.48 0.46 5.3e-19 Glomerular filtration rate (creatinine); CRC cis rs7474896 0.616 rs2474561 chr10:38373544 C/T cg25427524 chr10:38739819 LOC399744 -0.52 -6.16 -0.32 2.13e-9 Obesity (extreme); CRC cis rs7927771 1.000 rs34910028 chr11:47758449 T/C cg18512352 chr11:47633146 NA -0.5 -9.54 -0.47 3.37e-19 Subjective well-being; CRC cis rs11148252 0.846 rs9379 chr13:53050479 G/A cg12458913 chr13:53173898 NA 0.56 8.7 0.43 1.66e-16 Lewy body disease; CRC cis rs2637266 0.538 rs11001860 chr10:78473388 G/T cg18941641 chr10:78392320 NA -0.35 -5.88 -0.31 9.86e-9 Pulmonary function; CRC cis rs6484504 0.576 rs208093 chr11:31184400 C/T cg14844989 chr11:31128820 NA 0.33 5.94 0.31 7.08e-9 Red blood cell count; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg14559409 chr10:65930703 NA -0.43 -6.92 -0.36 2.32e-11 Liver disease severity in Alagille syndrome; CRC cis rs7762018 1.000 rs7747645 chr6:170070291 G/C cg19338460 chr6:170058176 WDR27 -0.76 -8.3 -0.42 2.78e-15 Thiazide-induced adverse metabolic effects in hypertensive patients; CRC trans rs10802346 0.545 rs10802345 chr1:246372834 C/T cg13514129 chr1:39547527 MACF1 0.57 8.6 0.43 3.25e-16 Fractional exhaled nitric oxide (childhood); CRC cis rs7927592 0.913 rs10047412 chr11:68232912 T/C cg01657329 chr11:68192670 LRP5 -0.46 -6.59 -0.34 1.72e-10 Total body bone mineral density; CRC cis rs67340775 0.541 rs200965 chr6:27866384 G/A cg03623178 chr6:28175578 NA 0.92 9.6 0.47 2.07e-19 Lung cancer in ever smokers; CRC trans rs1997103 1.000 rs6966183 chr7:55407546 A/C cg20935933 chr6:143382018 AIG1 0.51 6.65 0.34 1.25e-10 QRS interval (sulfonylurea treatment interaction); CRC cis rs875971 0.964 rs12668936 chr7:65914404 C/T cg18876405 chr7:65276391 NA 0.52 8.79 0.44 8.22e-17 Aortic root size; CRC cis rs28386778 0.897 rs894408 chr17:61896814 C/T cg22520471 chr17:61851767 DDX42;CCDC47 0.75 11.75 0.54 7.35e-27 Prudent dietary pattern; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg23120805 chr2:43453872 LOC100129726;ZFP36L2 0.39 6.0 0.31 5.16e-9 Intelligence (multi-trait analysis); CRC cis rs7666738 0.962 rs13147921 chr4:99069296 C/G cg05340658 chr4:99064831 C4orf37 0.52 7.24 0.37 3.23e-12 Colonoscopy-negative controls vs population controls; CRC cis rs2032447 0.714 rs199726 chr6:25953360 G/A cg12310025 chr6:25882481 NA -0.55 -7.94 -0.4 3.2e-14 Intelligence (multi-trait analysis); CRC cis rs4662945 0.504 rs35568023 chr2:130251812 A/T cg05903289 chr2:130345205 NA -0.36 -6.97 -0.36 1.79e-11 Response to cytidine analogues (gemcitabine); CRC trans rs9956878 0.555 rs8085188 chr18:73544676 A/G cg05935360 chr19:11639865 ECSIT -0.41 -6.59 -0.34 1.79e-10 Obesity-related traits; CRC cis rs926938 0.584 rs869990 chr1:115379614 A/G cg12756093 chr1:115239321 AMPD1 -0.58 -8.51 -0.42 6.34e-16 Autism; CRC cis rs79387448 0.745 rs17027430 chr2:103163237 T/C cg00507830 chr2:103233733 NA 0.51 5.61 0.3 4.25e-8 Gut microbiota (bacterial taxa); CRC cis rs4862750 0.837 rs1863404 chr4:187874654 T/C cg10295955 chr4:187884368 NA -0.98 -23.09 -0.79 8.68e-71 Lobe attachment (rater-scored or self-reported); CRC cis rs11628318 0.614 rs7143783 chr14:103128751 A/G cg23461800 chr14:103021989 NA 0.68 7.74 0.39 1.23e-13 Platelet count; CRC trans rs61931739 0.500 rs12809868 chr12:34464905 C/T cg26384229 chr12:38710491 ALG10B 0.67 8.79 0.44 8.19e-17 Morning vs. evening chronotype; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg12356431 chr5:177591266 NA 0.48 6.79 0.35 5.22e-11 Response to antipsychotic treatment; CRC trans rs11088226 0.846 rs2154501 chr21:33926451 G/A cg09050820 chr6:167586206 TCP10L2 0.68 8.62 0.43 2.96e-16 Gastritis; CRC cis rs6545883 0.868 rs6748003 chr2:61806700 T/G cg15711740 chr2:61764176 XPO1 -0.53 -7.24 -0.37 3.26e-12 Tuberculosis; CRC cis rs1448094 0.511 rs17279240 chr12:86162550 A/T cg00310523 chr12:86230176 RASSF9 0.36 5.91 0.31 8.34e-9 Major depressive disorder; CRC trans rs3857536 0.505 rs208459 chr6:66911055 C/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.64 -8.73 -0.43 1.3e-16 Blood trace element (Cu levels); CRC trans rs3749237 1.000 rs11710675 chr3:49751900 C/A cg21659725 chr3:3221576 CRBN 0.58 8.5 0.42 6.71e-16 Resting heart rate; CRC cis rs8099014 0.731 rs4261624 chr18:56101290 T/A cg19312305 chr18:56117016 MIR122 -0.43 -5.96 -0.31 6.55e-9 Platelet count; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg27544288 chr4:103940923 NHEDC1 0.37 6.18 0.32 1.93e-9 Liver disease severity in Alagille syndrome; CRC cis rs13118159 0.550 rs2878607 chr4:1353310 G/C cg16405210 chr4:1374714 KIAA1530 -0.91 -14.36 -0.62 1.19e-36 Longevity; CRC cis rs6495122 0.501 rs7163636 chr15:75346760 C/T cg18612461 chr15:75251733 NA 0.36 5.61 0.3 4.31e-8 Caffeine consumption;Diastolic blood pressure;Coffee consumption; CRC cis rs317865 0.737 rs73234642 chr4:16186730 G/C cg04764131 chr4:16228633 TAPT1;FLJ39653 0.63 5.72 0.3 2.4e-8 Kidney disease (early stage) in type 1 diabetes; CRC cis rs7177699 0.557 rs8027833 chr15:79112837 T/C cg15571903 chr15:79123663 NA 0.31 6.14 0.32 2.31e-9 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; CRC cis rs514406 0.679 rs11585495 chr1:53244331 T/C cg27535305 chr1:53392650 SCP2 0.47 8.53 0.43 5.33e-16 Monocyte count; CRC cis rs911119 0.908 rs6048949 chr20:23603199 C/T cg16589663 chr20:23618590 CST3 0.45 6.32 0.33 8.44e-10 Chronic kidney disease; CRC cis rs853679 0.760 rs967005 chr6:28210688 C/T cg25164649 chr6:28176230 NA 0.55 5.75 0.3 2e-8 Depression; CRC cis rs870825 0.929 rs55880126 chr4:185591237 T/G cg07424746 chr4:185654737 MLF1IP -0.63 -5.98 -0.31 5.66e-9 Blood protein levels; CRC trans rs10983614 1.000 rs7867776 chr9:120072627 A/G cg21803754 chr20:60718392 PSMA7;SS18L1 0.43 6.01 0.31 4.97e-9 Survival in pancreatic cancer; CRC cis rs6951245 0.572 rs80133931 chr7:1027286 C/T cg20603222 chr7:1096387 C7orf50;GPR146 -0.74 -5.99 -0.31 5.42e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs1129187 0.755 rs9462855 chr6:42925936 G/C cg02359409 chr6:42947317 PEX6 -0.69 -11.35 -0.53 2.01e-25 Alzheimer's disease in APOE e4+ carriers; CRC cis rs2839186 0.900 rs2839196 chr21:47708037 G/A cg26721908 chr21:47610096 LSS -0.4 -6.04 -0.32 4.26e-9 Testicular germ cell tumor; CRC cis rs7618501 0.633 rs6792892 chr3:49995518 T/C cg05623727 chr3:50126028 RBM5 0.46 7.58 0.39 3.49e-13 Intelligence (multi-trait analysis); CRC cis rs7937682 0.593 rs1944121 chr11:111347223 T/C cg09085632 chr11:111637200 PPP2R1B 0.43 5.85 0.31 1.22e-8 Primary sclerosing cholangitis; CRC cis rs3812565 0.506 rs4259518 chr9:139322503 T/C cg14019695 chr9:139328340 INPP5E 0.44 6.39 0.33 5.62e-10 Granulocyte percentage of myeloid white cells; CRC cis rs524281 0.684 rs7946447 chr11:65864338 T/C cg14036092 chr11:66035641 RAB1B -0.45 -5.74 -0.3 2.14e-8 Electroencephalogram traits; CRC cis rs11191205 0.686 rs11191070 chr10:103396862 C/T cg15320455 chr10:103880129 LDB1 0.56 6.19 0.32 1.77e-9 Intelligence (multi-trait analysis); CRC cis rs490234 0.783 rs10119855 chr9:128271123 A/T cg14078157 chr9:128172775 NA -0.4 -6.74 -0.35 7.28e-11 Mean arterial pressure; CRC cis rs3733585 0.781 rs6449183 chr4:9970691 C/A cg11266682 chr4:10021025 SLC2A9 -0.47 -9.58 -0.47 2.55e-19 Cleft plate (environmental tobacco smoke interaction); CRC cis rs995000 0.931 rs10789117 chr1:63072265 A/C cg19896129 chr1:63156450 NA 0.43 6.75 0.35 6.54e-11 Triglyceride levels; CRC cis rs73001065 0.901 rs8107974 chr19:19388500 A/T cg03709012 chr19:19516395 GATAD2A 0.81 5.9 0.31 8.83e-9 LDL cholesterol; CRC cis rs801193 0.569 rs35070132 chr7:66238083 C/T cg00343986 chr7:65444356 GUSB 0.41 5.67 0.3 3.15e-8 Aortic root size; CRC cis rs6933660 0.646 rs3816778 chr6:151773353 G/C cg14262678 chr6:151773367 RMND1;C6orf211 0.59 10.05 0.48 6.89e-21 Menarche (age at onset); CRC cis rs6502050 0.697 rs8078634 chr17:80126208 C/T cg19223190 chr17:80058835 NA 0.42 6.52 0.34 2.69e-10 Life satisfaction; CRC cis rs9381040 0.674 rs4711657 chr6:41162715 G/A cg03644281 chr6:41068752 NFYA;LOC221442 -0.5 -6.93 -0.36 2.22e-11 Alzheimer's disease (late onset); CRC trans rs12643440 0.585 rs601517 chr4:17167630 T/C cg16738984 chr19:14519121 CD97 0.2 5.98 0.31 5.8e-9 Metabolite levels (Pyroglutamine); CRC cis rs514406 0.679 rs12563825 chr1:53238324 G/T cg24675658 chr1:53192096 ZYG11B 0.77 11.99 0.55 1.01e-27 Monocyte count; CRC cis rs1129187 0.755 rs9462855 chr6:42925936 G/C cg21280719 chr6:42927975 GNMT -0.46 -10.37 -0.5 5.51e-22 Alzheimer's disease in APOE e4+ carriers; CRC cis rs2811415 0.597 rs3733158 chr3:127787157 A/G cg13719885 chr3:127795394 NA -0.39 -5.95 -0.31 6.69e-9 Lung function (FEV1/FVC); CRC cis rs4957048 0.577 rs56294732 chr5:568144 T/C cg16447950 chr5:562315 NA -0.85 -13.07 -0.58 1.01e-31 Ulcerative colitis; CRC cis rs10450586 0.932 rs10767630 chr11:27314069 A/T cg10370305 chr11:27303972 NA 0.35 5.69 0.3 2.76e-8 Total body bone mineral density; CRC trans rs6550704 0.687 rs9865314 chr3:22634337 A/G cg18845289 chr12:121124611 MLEC -0.41 -6.22 -0.32 1.53e-9 Daytime sleep phenotypes; CRC cis rs561341 1.000 rs7216102 chr17:30259450 A/G cg23018236 chr17:30244563 NA -0.47 -6.65 -0.34 1.23e-10 Hip circumference adjusted for BMI; CRC cis rs1862618 0.573 rs2034245 chr5:56243685 T/C cg12311346 chr5:56204834 C5orf35 0.9 12.69 0.57 2.51e-30 Initial pursuit acceleration; CRC cis rs919433 0.857 rs36071109 chr2:198183191 C/A cg10820045 chr2:198174542 NA -0.56 -9.94 -0.48 1.61e-20 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC cis rs10463316 0.862 rs7720582 chr5:150776502 C/T cg03212797 chr5:150827313 SLC36A1 0.48 7.66 0.39 2.08e-13 Metabolite levels (Pyroglutamine); CRC cis rs2658782 1.000 rs2658781 chr11:93166368 C/T cg21115391 chr11:93143810 CCDC67 0.39 5.81 0.3 1.5e-8 Pulmonary function decline; CRC cis rs78456975 0.739 rs72776248 chr2:1521314 A/G cg12573674 chr2:1569213 NA -0.64 -6.89 -0.36 2.81e-11 Placebo response in major depressive disorder (% change in symptom score); CRC cis rs2979489 0.891 rs17627965 chr8:30354376 C/T cg26383811 chr8:30366931 RBPMS 0.64 9.15 0.45 6.21e-18 Mean corpuscular hemoglobin;Plateletcrit;Neutrophil count;Granulocyte count;Sum basophil neutrophil counts;Mean corpuscular volume;Myeloid white cell count;Sum neutrophil eosinophil counts; CRC cis rs66887589 0.934 rs41464847 chr4:120532401 A/G cg09307838 chr4:120376055 NA -0.51 -7.87 -0.4 5.06e-14 Diastolic blood pressure; CRC cis rs12753569 0.934 rs6676370 chr1:76490185 G/T cg00791851 chr1:76518896 NA -0.4 -7.14 -0.37 5.94e-12 Personality dimensions; CRC cis rs10504229 0.906 rs114810777 chr8:58185298 A/G cg22535103 chr8:58192502 C8orf71 -0.81 -12.18 -0.56 1.96e-28 Developmental language disorder (linguistic errors); CRC cis rs9322193 0.962 rs6899661 chr6:150139229 T/C cg13206674 chr6:150067644 NUP43 0.58 8.17 0.41 6.79e-15 Lung cancer; CRC cis rs10504229 1.000 rs67705655 chr8:58177688 G/A cg02725872 chr8:58115012 NA -0.38 -6.43 -0.33 4.44e-10 Developmental language disorder (linguistic errors); CRC cis rs6088580 0.634 rs6059860 chr20:33063830 A/C cg08999081 chr20:33150536 PIGU 0.61 11.44 0.53 9.47e-26 Glomerular filtration rate (creatinine); CRC cis rs35110281 0.686 rs162399 chr21:44950020 G/A cg04455712 chr21:45112962 RRP1B 0.42 8.19 0.41 5.67e-15 Mean corpuscular volume; CRC cis rs2836633 0.929 rs58120977 chr21:40037346 C/T cg12884169 chr21:40033163 ERG 0.43 10.05 0.48 6.76e-21 Coronary artery disease; CRC trans rs116095464 0.558 rs10076655 chr5:239464 G/C cg00938859 chr5:1591904 SDHAP3 0.74 7.92 0.4 3.68e-14 Breast cancer; CRC cis rs1577917 0.958 rs7747897 chr6:86647349 A/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.52 -6.78 -0.35 5.63e-11 Response to antipsychotic treatment; CRC cis rs875971 1.000 rs55962648 chr7:65625751 C/G cg18876405 chr7:65276391 NA -0.53 -9.23 -0.45 3.49e-18 Aortic root size; CRC cis rs9487051 0.714 rs7774377 chr6:109602443 G/A cg12927641 chr6:109611667 NA -0.39 -6.88 -0.35 3.11e-11 Reticulocyte fraction of red cells; CRC cis rs3824867 0.920 rs3740685 chr11:47468791 C/T cg20307385 chr11:47447363 PSMC3 0.44 5.62 0.3 4.14e-8 Mean corpuscular hemoglobin; CRC cis rs2011503 1.000 rs11669730 chr19:19648713 G/A cg11584989 chr19:19387371 SF4 0.58 6.47 0.34 3.47e-10 Bipolar disorder; CRC cis rs8060686 0.545 rs12596883 chr16:68172416 A/T cg26727032 chr16:67993705 SLC12A4 -0.57 -6.1 -0.32 3.03e-9 HDL cholesterol;Metabolic syndrome; CRC cis rs898097 0.812 rs56274787 chr17:80862682 C/T cg15369054 chr17:80825471 TBCD 0.52 8.44 0.42 9.99e-16 Breast cancer; CRC cis rs6500602 0.627 rs6500610 chr16:4529613 A/G cg06139259 chr16:4526053 HMOX2;NMRAL1 0.55 7.22 0.37 3.72e-12 Schizophrenia; CRC cis rs6860806 0.631 rs4705931 chr5:131588345 T/C cg04518342 chr5:131593106 PDLIM4 0.48 8.81 0.44 7.59e-17 Breast cancer; CRC cis rs3858526 0.959 rs61876223 chr11:5943393 G/A cg02574844 chr11:5959923 NA -0.46 -6.45 -0.33 4.02e-10 DNA methylation (variation); CRC cis rs7666738 0.830 rs11941844 chr4:99042722 A/T cg17366294 chr4:99064904 C4orf37 0.45 7.73 0.39 1.34e-13 Colonoscopy-negative controls vs population controls; CRC cis rs763121 0.889 rs2267390 chr22:38889657 C/T cg06544989 chr22:39130855 UNC84B 0.43 6.43 0.33 4.49e-10 Menopause (age at onset); CRC cis rs7223966 1.000 rs72848797 chr17:61934664 G/A cg23090583 chr17:61904693 PSMC5;FTSJ3 0.6 7.31 0.37 2.04e-12 Hip circumference adjusted for BMI;Body mass index; CRC trans rs7027930 0.524 rs6477035 chr9:618490 G/T cg27061366 chr19:13044373 FARSA 0.53 6.48 0.34 3.25e-10 Pulmonary function decline; CRC cis rs9733 0.596 rs11582840 chr1:150688487 A/G cg10589385 chr1:150898437 SETDB1 0.28 5.96 0.31 6.66e-9 Tonsillectomy; CRC cis rs1577917 0.958 rs6900436 chr6:86506288 T/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.51 -6.67 -0.35 1.06e-10 Response to antipsychotic treatment; CRC cis rs4787491 0.729 rs3814878 chr16:30041966 A/G cg08188419 chr16:30022634 DOC2A 0.38 5.66 0.3 3.34e-8 Body mass index;BMI (adjusted for smoking behaviour);BMI in non-smokers;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs4953076 0.573 rs7602070 chr2:44388614 G/A cg04920474 chr2:44395004 PPM1B 0.55 7.42 0.38 1.03e-12 Height; CRC cis rs7584330 0.740 rs13418586 chr2:238445593 A/G cg14458575 chr2:238380390 NA 0.43 7.62 0.39 2.82e-13 Prostate cancer; CRC cis rs3760982 1.000 rs10421887 chr19:44294849 C/T cg21496419 chr19:44306685 LYPD5 -0.34 -6.38 -0.33 6.09e-10 Breast cancer (estrogen-receptor negative);Breast cancer; CRC cis rs801193 0.844 rs7779971 chr7:66161790 T/C cg18876405 chr7:65276391 NA 0.61 10.76 0.51 2.53e-23 Aortic root size; CRC cis rs11229555 1.000 rs12799215 chr11:58405674 C/T cg15696309 chr11:58395628 NA -0.96 -13.63 -0.6 7.41e-34 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; CRC trans rs6952808 0.717 rs10950422 chr7:1926577 T/C cg04565464 chr8:145669602 NFKBIL2 0.39 6.12 0.32 2.73e-9 Bipolar disorder and schizophrenia; CRC trans rs10982213 0.830 rs2274163 chr9:117188714 C/T cg21956150 chr19:1438388 RPS15 0.41 6.27 0.33 1.1e-9 Interleukin-6 levels; CRC cis rs2153535 0.580 rs1855769 chr6:8473095 A/G cg21535247 chr6:8435926 SLC35B3 0.49 7.45 0.38 8.13e-13 Motion sickness; CRC cis rs758324 0.947 rs13154286 chr5:131160189 A/G cg25547332 chr5:131281432 NA 0.39 5.73 0.3 2.25e-8 Alzheimer's disease in APOE e4- carriers; CRC cis rs11025559 0.773 rs10833334 chr11:20498640 T/C cg19653624 chr11:20408972 PRMT3 -0.68 -7.97 -0.4 2.55e-14 Pursuit maintenance gain; CRC cis rs9443645 0.901 rs9361451 chr6:79555055 T/C cg09184832 chr6:79620586 NA -0.51 -9.72 -0.47 8.19e-20 Intelligence (multi-trait analysis); CRC cis rs4664293 0.867 rs6432558 chr2:160601908 G/A cg08347373 chr2:160653686 CD302 -0.47 -7.43 -0.38 9.32e-13 Monocyte percentage of white cells; CRC trans rs11098499 0.863 rs34308924 chr4:120481431 T/C cg25214090 chr10:38739885 LOC399744 0.66 10.41 0.5 4.04e-22 Corneal astigmatism; CRC cis rs9491140 0.539 rs11154230 chr6:124686156 A/G cg05308643 chr6:124982296 NKAIN2 0.47 6.59 0.34 1.7e-10 Neuroticism; CRC cis rs7224685 0.501 rs2676276 chr17:3919981 C/T cg21851534 chr17:3907994 ZZEF1 -0.37 -6.72 -0.35 7.78e-11 Type 2 diabetes; CRC cis rs11758351 0.518 rs78871852 chr6:26221566 A/T cg08260959 chr6:26240920 HIST1H4F -0.35 -5.66 -0.3 3.38e-8 Gout;Renal underexcretion gout; CRC cis rs9322193 0.923 rs2342857 chr6:150130673 G/A cg00933542 chr6:150070202 PCMT1 0.28 5.68 0.3 2.98e-8 Lung cancer; CRC cis rs875971 0.755 rs76288834 chr7:66069802 G/A cg12463550 chr7:65579703 CRCP -0.48 -6.39 -0.33 5.55e-10 Aortic root size; CRC cis rs10504229 0.906 rs112793785 chr8:58190537 T/C cg22535103 chr8:58192502 C8orf71 -0.81 -12.2 -0.56 1.72e-28 Developmental language disorder (linguistic errors); CRC cis rs6540559 0.673 rs114467813 chr1:210017785 G/A cg22029157 chr1:209979665 IRF6 0.66 7.25 0.37 2.97e-12 Cleft lip with or without cleft palate; CRC cis rs2274273 0.805 rs10131926 chr14:55713246 T/C cg23234261 chr14:55582407 NA -0.29 -5.73 -0.3 2.24e-8 Protein biomarker; CRC cis rs6662572 1.000 rs72688469 chr1:46118393 T/A cg03123370 chr1:45965343 CCDC163P;MMACHC 0.49 5.74 0.3 2.18e-8 Blood protein levels; CRC cis rs1153858 1.000 rs56850226 chr15:45633118 T/C cg14582100 chr15:45693742 SPATA5L1 0.29 5.94 0.31 7.29e-9 Homoarginine levels; CRC cis rs9902453 0.791 rs6505141 chr17:27998187 T/A cg26525008 chr17:28256777 EFCAB5;SSH2 0.72 12.14 0.56 2.94e-28 Coffee consumption (cups per day); CRC cis rs6860806 0.507 rs272878 chr5:131671769 C/T cg18758796 chr5:131593413 PDLIM4 -0.42 -6.95 -0.36 1.91e-11 Breast cancer; CRC cis rs79387448 0.745 rs78136548 chr2:103103740 T/G cg00507830 chr2:103233733 NA 0.67 6.48 0.34 3.4e-10 Gut microbiota (bacterial taxa); CRC cis rs9303401 0.614 rs34941454 chr17:57102742 T/G cg02118635 chr17:56770003 RAD51C;TEX14 0.69 8.77 0.44 9.61e-17 Cognitive test performance; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg12598163 chr13:111806585 ARHGEF7 0.43 6.46 0.34 3.66e-10 Liver disease severity in Alagille syndrome; CRC cis rs1552244 0.816 rs13076197 chr3:10019773 T/C cg10729496 chr3:10149963 C3orf24 0.48 6.25 0.33 1.25e-9 Alzheimer's disease; CRC cis rs2019137 0.936 rs731834 chr2:113957198 A/C cg19083407 chr2:113993142 PAX8;LOC440839;LOC654433 -0.46 -6.45 -0.34 4e-10 Lymphocyte counts; CRC cis rs11997175 0.624 rs4733460 chr8:33675169 T/C cg04338863 chr8:33670619 NA 0.46 7.29 0.37 2.31e-12 Body mass index; CRC cis rs11098499 0.644 rs2389880 chr4:120559870 T/A cg09307838 chr4:120376055 NA 0.62 9.5 0.46 4.49e-19 Corneal astigmatism; CRC trans rs9858213 1 rs9858213 chr3:49731861 G/T cg21665057 chr3:196295764 WDR53;FBXO45 -0.68 -8.72 -0.43 1.42e-16 Educational attainment; CRC cis rs17666538 0.585 rs1669733 chr8:606696 C/T cg23958373 chr8:599963 NA -0.83 -7.76 -0.39 1.11e-13 IgG glycosylation; CRC cis rs8180040 0.764 rs4683324 chr3:47251284 T/C cg27129171 chr3:47204927 SETD2 0.75 12.83 0.58 7.79e-31 Colorectal cancer; CRC cis rs12044355 0.927 rs11585959 chr1:231833718 C/T cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.47 -6.55 -0.34 2.28e-10 Alzheimer's disease; CRC cis rs6076065 0.630 rs2424559 chr20:23430519 A/G cg11657817 chr20:23433608 CST11 0.53 8.92 0.44 3.24e-17 Facial morphology (factor 15, philtrum width); CRC cis rs7615952 0.599 rs67566088 chr3:125768973 C/A cg15145296 chr3:125709740 NA -0.58 -6.83 -0.35 4.22e-11 Blood pressure (smoking interaction); CRC cis rs7914558 1.000 rs2275271 chr10:104814162 T/C cg15744005 chr10:104629667 AS3MT -0.33 -7.06 -0.36 9.89e-12 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC trans rs1814175 0.746 rs10839429 chr11:49906845 G/A cg03929089 chr4:120376271 NA -0.98 -19.27 -0.73 6.62e-56 Height; CRC cis rs3849570 0.695 rs6804587 chr3:81873423 T/C cg07356753 chr3:81810745 GBE1 -0.6 -8.08 -0.41 1.22e-14 Waist circumference;Body mass index; CRC cis rs7618915 0.570 rs13068293 chr3:52672167 C/A cg15147215 chr3:52552868 STAB1 -0.62 -10.24 -0.49 1.48e-21 Bipolar disorder; CRC cis rs17023223 0.537 rs61319010 chr1:119743011 T/A cg05756136 chr1:119680316 WARS2 -0.53 -7.15 -0.37 5.56e-12 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for BMI in active individuals; CRC cis rs3858526 0.523 rs10838750 chr11:5886246 C/T cg02574844 chr11:5959923 NA 0.52 7.65 0.39 2.24e-13 DNA methylation (variation); CRC cis rs1552244 0.882 rs112621205 chr3:10017916 G/A cg13047869 chr3:10149882 C3orf24 0.51 6.91 0.36 2.54e-11 Alzheimer's disease; CRC cis rs9467711 0.591 rs67296946 chr6:26048559 T/G cg19084075 chr6:26124329 HIST1H2AC;HIST1H2BC 0.65 6.1 0.32 2.93e-9 Autism spectrum disorder or schizophrenia; CRC cis rs10504229 0.683 rs61364624 chr8:58134339 T/A cg04204079 chr8:58130323 NA -0.45 -5.78 -0.3 1.71e-8 Developmental language disorder (linguistic errors); CRC cis rs16867321 0.951 rs1901749 chr2:181350633 G/A cg23363182 chr2:181467187 NA -0.53 -6.26 -0.33 1.18e-9 Obesity; CRC trans rs8002861 0.664 rs895266 chr13:44461179 T/C cg12856521 chr11:46389249 DGKZ 0.43 6.67 0.35 1.11e-10 Leprosy; CRC trans rs951252 0.504 rs11734405 chr4:146081096 C/T cg14653225 chr1:228003938 PRSS38 -0.42 -6.03 -0.32 4.41e-9 Hip circumference; CRC cis rs4901869 0.966 rs9972208 chr14:59336116 C/T cg02291164 chr14:59296302 NA 0.34 6.26 0.33 1.22e-9 Panic disorder; CRC cis rs7773004 0.875 rs9393700 chr6:26309380 G/A cg00631329 chr6:26305371 NA -0.41 -6.93 -0.36 2.19e-11 Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for body mass index;Waist circumference adjusted for BMI in non-smokers;Waist circumference adjusted for BMI (adjusted for smoking behaviour); CRC cis rs6582630 0.513 rs1596446 chr12:38282160 C/T cg26384229 chr12:38710491 ALG10B -0.64 -9.23 -0.45 3.34e-18 Drug-induced liver injury (flucloxacillin); CRC cis rs2522056 1.000 rs2522056 chr5:131801726 C/T cg24060327 chr5:131705240 SLC22A5 0.39 5.65 0.3 3.52e-8 Lymphocyte counts;Fibrinogen; CRC cis rs9522267 0.535 rs9522303 chr13:112237301 T/C cg14352298 chr13:112236639 NA 0.29 6.59 0.34 1.74e-10 Hepatitis; CRC cis rs9399135 0.967 rs4895439 chr6:135318854 A/T cg24558204 chr6:135376177 HBS1L 0.51 8.11 0.41 1.01e-14 Red blood cell count; CRC cis rs12431939 1.000 rs4567626 chr14:51647640 A/T cg23942311 chr14:51606299 NA 0.48 5.67 0.3 3.16e-8 Cancer; CRC cis rs40363 0.645 rs250631 chr16:3523215 G/C cg00484396 chr16:3507460 NAT15 0.53 7.72 0.39 1.43e-13 Tuberculosis; CRC cis rs7937682 0.924 rs12791699 chr11:111505880 T/C cg19812747 chr11:111475976 SIK2 -0.59 -10.07 -0.49 5.54e-21 Primary sclerosing cholangitis; CRC cis rs9393692 0.620 rs9379844 chr6:26291527 A/G cg13736514 chr6:26305472 NA 0.46 7.46 0.38 7.95e-13 Educational attainment; CRC cis rs1971762 0.563 rs10219725 chr12:54080865 T/G cg06632207 chr12:54070931 ATP5G2 0.4 6.91 0.36 2.6e-11 Height; CRC cis rs9894429 1.000 rs12948099 chr17:79600799 C/G cg18240062 chr17:79603768 NPLOC4 0.54 9.2 0.45 4.28e-18 Eye color traits; CRC cis rs13191362 1.000 rs71567659 chr6:163001736 G/A cg23758597 chr6:163146217 PARK2 -0.55 -6.12 -0.32 2.61e-9 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs875971 1.000 rs6958484 chr7:65599446 G/A cg12463550 chr7:65579703 CRCP -0.47 -6.74 -0.35 7.05e-11 Aortic root size; CRC cis rs3772130 0.962 rs35679661 chr3:121484763 G/A cg20356878 chr3:121714668 ILDR1 0.52 8.11 0.41 1e-14 Cognitive performance; CRC cis rs78456975 0.506 rs13384333 chr2:1555531 A/C cg26248373 chr2:1572462 NA -0.74 -10.3 -0.49 9.68e-22 Placebo response in major depressive disorder (% change in symptom score); CRC cis rs10046574 0.519 rs10250947 chr7:135211017 T/G cg27474649 chr7:135195673 CNOT4 0.6 5.88 0.31 1.01e-8 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs7917772 0.582 rs4285804 chr10:104386309 T/A cg11453585 chr10:104263688 ACTR1A;SUFU -0.79 -13.59 -0.6 1.03e-33 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC cis rs7632954 1.000 rs9312021 chr3:8526809 T/A cg03495237 chr3:8533978 NA 0.33 5.86 0.31 1.12e-8 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs9291683 0.509 rs998676 chr4:9948564 T/C cg11266682 chr4:10021025 SLC2A9 -0.51 -10.3 -0.49 9.26e-22 Bone mineral density; CRC cis rs2404602 0.735 rs2454454 chr15:76823647 A/G cg23625390 chr15:77176239 SCAPER -0.76 -12.32 -0.56 6.4e-29 Blood metabolite levels; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg21638108 chr19:19431283 KIAA0892;SF4 0.43 7.2 0.37 4.01e-12 Liver disease severity in Alagille syndrome; CRC cis rs6860806 0.695 rs11952099 chr5:131576772 A/G cg18301423 chr5:131593218 PDLIM4 0.38 7.09 0.36 8.19e-12 Breast cancer; CRC cis rs4713118 0.738 rs200465 chr6:27757654 T/A cg12172441 chr6:28176163 NA 0.54 6.97 0.36 1.74e-11 Parkinson's disease; CRC cis rs11382616 1 rs11382616 chr14:103081465 G/GC cg12046867 chr14:103022105 NA -0.41 -5.61 -0.3 4.27e-8 Plateletcrit;Platelet count; CRC cis rs3096299 0.719 rs2965817 chr16:89513234 C/T cg02187348 chr16:89574699 SPG7 0.38 5.7 0.3 2.61e-8 Multiple myeloma (IgH translocation); CRC cis rs668210 0.793 rs677350 chr11:65761967 G/A cg02202077 chr11:65769826 EIF1AD;BANF1 0.47 6.31 0.33 8.99e-10 Cerebrospinal fluid biomarker levels; CRC cis rs1862618 0.853 rs2548664 chr5:56133555 G/A cg03609598 chr5:56110824 MAP3K1 -0.81 -10.01 -0.48 8.99e-21 Initial pursuit acceleration; CRC cis rs67340775 0.541 rs200964 chr6:27866943 G/C cg06470822 chr6:28175283 NA 0.87 9.01 0.44 1.74e-17 Lung cancer in ever smokers; CRC cis rs11148252 0.875 rs4885953 chr13:52976491 G/A cg00495681 chr13:53174319 NA 0.51 7.7 0.39 1.5700000000000001e-13 Lewy body disease; CRC cis rs870825 0.616 rs10025167 chr4:185649551 A/C cg04058563 chr4:185651563 MLF1IP 0.72 9.3 0.46 2.04e-18 Blood protein levels; CRC cis rs7843479 0.506 rs7818430 chr8:21798429 C/T cg17168535 chr8:21777572 XPO7 0.65 11.06 0.52 2.14e-24 Mean corpuscular volume; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg14415379 chr5:118324374 DTWD2 0.45 6.73 0.35 7.48e-11 Intelligence (multi-trait analysis); CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg01370623 chr17:35849806 DUSP14 0.49 6.3 0.33 9.52e-10 Anxiety disorder; CRC cis rs9942416 0.660 rs17563863 chr5:74998334 G/A cg00601450 chr5:74908170 NA 0.4 5.64 0.3 3.71e-8 Age-related disease endophenotypes; CRC cis rs1799949 0.965 rs11657883 chr17:41330024 T/C cg05368731 chr17:41323189 NBR1 0.65 9.54 0.47 3.3e-19 Menopause (age at onset); CRC cis rs13191362 0.935 rs34141091 chr6:162953893 T/A cg06582575 chr6:163149167 PACRG;PARK2 0.79 9.71 0.47 9.3e-20 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs523522 0.962 rs7136951 chr12:120941927 C/T cg27279351 chr12:120934652 DYNLL1 0.75 11.24 0.53 5.11e-25 High light scatter reticulocyte count; CRC cis rs72945132 0.882 rs17425511 chr11:70183737 C/G cg14191688 chr11:70257035 CTTN 0.45 5.84 0.31 1.26e-8 Coronary artery disease; CRC cis rs12477438 0.765 rs7591794 chr2:99567514 T/C cg26064155 chr2:99771622 LIPT1;TSGA10 -0.63 -8.82 -0.44 6.69e-17 Chronic sinus infection; CRC cis rs6693567 0.565 rs3754217 chr1:150480373 G/T cg15654264 chr1:150340011 RPRD2 0.4 5.73 0.3 2.3e-8 Migraine; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg22985182 chr3:156273085 SSR3 0.45 6.21 0.32 1.64e-9 Response to antipsychotic treatment; CRC trans rs2303319 0.504 rs1006428 chr2:162592559 A/C cg09481857 chr22:21368659 P2RX6;MGC16703 -0.65 -6.31 -0.33 9.13e-10 Cognitive function; CRC cis rs62158211 1.000 rs1807282 chr2:114110036 A/T cg17784749 chr2:114082611 LOC440839 0.56 6.58 0.34 1.9e-10 Sleep duration (oversleepers vs undersleepers);Sleep traits (multi-trait analysis);Sleep duration; CRC cis rs1401999 0.690 rs1402001 chr3:183642751 A/G cg01324343 chr3:183735012 ABCC5 0.6 9.47 0.46 5.48e-19 Anterior chamber depth; CRC trans rs2840044 1.000 rs225295 chr17:33925755 A/G cg19694781 chr19:47549865 TMEM160 -0.44 -7.0 -0.36 1.44e-11 Response to radiotherapy in cancer (late toxicity); CRC cis rs7635838 0.617 rs346075 chr3:11294027 T/G cg00170343 chr3:11313890 ATG7 0.57 8.95 0.44 2.68e-17 HDL cholesterol; CRC cis rs12908161 1.000 rs12908161 chr15:85207825 A/G cg17507749 chr15:85114479 UBE2QP1 0.61 8.57 0.43 4.09e-16 Schizophrenia; CRC cis rs7647973 1.000 rs11130189 chr3:49347357 C/A cg20833759 chr3:49053208 WDR6;DALRD3 0.53 7.94 0.4 3.32e-14 Menarche (age at onset); CRC cis rs6938 0.618 rs11857695 chr15:75165751 G/T cg17294928 chr15:75287854 SCAMP5 0.5 7.69 0.39 1.75e-13 Breast cancer; CRC cis rs853679 0.517 rs9393888 chr6:28059217 G/C cg02631126 chr6:28058918 ZSCAN12L1 0.3 6.09 0.32 3.18e-9 Depression; CRC cis rs7312774 0.881 rs12320167 chr12:107310167 G/A cg16260113 chr12:107380972 MTERFD3 0.74 7.49 0.38 6.31e-13 Severe influenza A (H1N1) infection; CRC cis rs9326248 0.520 rs236919 chr11:117095361 A/G cg20608306 chr11:116969690 SIK3 0.29 5.84 0.31 1.24e-8 Blood protein levels; CRC cis rs4665809 0.549 rs72809635 chr2:26411674 G/A cg08067268 chr2:26466485 HADHB;HADHA 0.64 7.41 0.38 1.05e-12 Gut microbiome composition (summer); CRC cis rs2456568 0.548 rs7117597 chr11:93655091 A/G cg26875233 chr11:93583750 C11orf90 -0.36 -7.02 -0.36 1.27e-11 Response to serotonin reuptake inhibitors in major depressive disorder; CRC cis rs6504950 0.705 rs9899545 chr17:52986845 T/C cg26251398 chr17:52985966 TOM1L1 0.41 6.06 0.32 3.66e-9 Breast cancer; CRC cis rs17092148 0.731 rs35507767 chr20:33361364 A/T cg08999081 chr20:33150536 PIGU 0.46 5.66 0.3 3.22e-8 Neuroticism; CRC cis rs6665290 0.901 rs11580229 chr1:227210820 G/A cg10327440 chr1:227177885 CDC42BPA -0.92 -17.71 -0.7 9.15e-50 Myeloid white cell count; CRC cis rs8067545 0.641 rs119672 chr17:19818601 A/G cg04132472 chr17:19861366 AKAP10 0.42 6.47 0.34 3.56e-10 Schizophrenia; CRC cis rs7647973 0.587 rs10452032 chr3:49680973 G/A cg13072238 chr3:49761600 GMPPB -0.52 -5.92 -0.31 8.06e-9 Menarche (age at onset); CRC cis rs2120019 1.000 rs35577967 chr15:75354621 G/A cg09165964 chr15:75287851 SCAMP5 -0.84 -12.74 -0.57 1.68e-30 Blood trace element (Zn levels); CRC cis rs10504229 0.683 rs6980850 chr8:58127204 A/G cg05313129 chr8:58192883 C8orf71 -0.43 -6.11 -0.32 2.74e-9 Developmental language disorder (linguistic errors); CRC cis rs875971 0.862 rs801195 chr7:66026115 A/G cg18876405 chr7:65276391 NA -0.52 -8.35 -0.42 1.91e-15 Aortic root size; CRC cis rs2011503 1.000 rs2965181 chr19:19512317 C/T cg11584989 chr19:19387371 SF4 0.56 6.26 0.33 1.2e-9 Bipolar disorder; CRC cis rs17253792 0.822 rs10147688 chr14:56054642 T/C cg24579896 chr14:56047964 C14orf33;KTN1 0.67 5.7 0.3 2.61e-8 Putamen volume; CRC cis rs6456156 0.846 rs7749827 chr6:167515624 C/T cg07513332 chr6:167530253 CCR6 -0.41 -7.13 -0.37 6.45e-12 Primary biliary cholangitis; CRC cis rs2346177 0.513 rs1530625 chr2:46658067 C/T cg02822958 chr2:46747628 ATP6V1E2 0.38 5.81 0.31 1.46e-8 HDL cholesterol; CRC trans rs7615952 0.512 rs4234285 chr3:125404477 G/A cg02007433 chr3:129722099 NA -0.61 -9.27 -0.46 2.51e-18 Blood pressure (smoking interaction); CRC cis rs2243480 1.000 rs6958420 chr7:65751171 A/G cg18252515 chr7:66147081 NA 1.27 14.66 0.63 8.59e-38 Diabetic kidney disease; CRC cis rs5771225 0.563 rs738334 chr22:50688235 T/C cg16473166 chr22:50639996 SELO 0.51 6.26 0.33 1.2e-9 Late-onset Alzheimer's disease; CRC cis rs6570726 0.935 rs380433 chr6:145859601 A/T cg05347473 chr6:146136440 FBXO30 0.38 6.05 0.32 4e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs7618915 0.547 rs2289250 chr3:52682946 A/C cg18099408 chr3:52552593 STAB1 0.46 7.64 0.39 2.44e-13 Bipolar disorder; CRC cis rs523522 0.962 rs3893104 chr12:120903936 G/A cg27279351 chr12:120934652 DYNLL1 0.79 11.41 0.53 1.2e-25 High light scatter reticulocyte count; CRC cis rs9926296 0.643 rs12596429 chr16:89841374 T/C cg04287289 chr16:89883240 FANCA 0.57 9.06 0.45 1.16e-17 Vitiligo; CRC cis rs2735413 0.918 rs4888728 chr16:78077199 C/G cg04733911 chr16:78082701 NA -0.45 -7.5 -0.38 6.09e-13 Systolic blood pressure (alcohol consumption interaction); CRC cis rs10782582 0.593 rs11578480 chr1:76208989 T/G cg03433033 chr1:76189801 ACADM -0.46 -6.72 -0.35 8e-11 Daytime sleep phenotypes; CRC cis rs1568889 1.000 rs66857704 chr11:28212346 A/G cg06544937 chr11:28130018 METT5D1;KIF18A 0.79 10.97 0.52 4.4e-24 Bipolar disorder; CRC cis rs2617583 0.967 rs2550946 chr5:1450513 A/G cg07151155 chr5:1473589 LPCAT1 -0.42 -6.49 -0.34 3.19e-10 Breast cancer; CRC cis rs2239547 0.618 rs1573815 chr3:52870132 A/G cg15147215 chr3:52552868 STAB1 0.46 6.56 0.34 2.11e-10 Schizophrenia; CRC cis rs861020 0.630 rs657861 chr1:210006884 C/G cg09163369 chr1:210001066 C1orf107 0.41 5.75 0.3 2.01e-8 Orofacial clefts; CRC cis rs6942756 1.000 rs6467235 chr7:128939150 A/G cg02491457 chr7:128862824 NA 0.7 10.16 0.49 2.78e-21 White matter hyperintensity burden; CRC cis rs9325144 0.560 rs12424821 chr12:38649951 C/T cg13010199 chr12:38710504 ALG10B -0.42 -6.12 -0.32 2.7e-9 Morning vs. evening chronotype; CRC cis rs950169 0.649 rs12905952 chr15:84691261 G/A cg11189052 chr15:85197271 WDR73 0.58 7.58 0.39 3.65e-13 Schizophrenia; CRC cis rs2302777 0.507 rs9889711 chr17:38108292 A/T cg17344932 chr17:38183730 MED24;SNORD124 -0.56 -8.92 -0.44 3.24e-17 Multiple myeloma (hyperdiploidy); CRC cis rs832540 0.656 rs2408597 chr5:56098632 G/A cg12311346 chr5:56204834 C5orf35 -0.49 -7.34 -0.38 1.64e-12 Coronary artery disease; CRC cis rs1129187 0.967 rs11752813 chr6:42928017 C/G cg02359409 chr6:42947317 PEX6 -0.57 -8.83 -0.44 6.16e-17 Alzheimer's disease in APOE e4+ carriers; CRC trans rs2303319 0.504 rs62189047 chr2:162613314 T/A cg23919916 chr10:103825097 HPS6 -0.69 -6.01 -0.31 4.8e-9 Cognitive function; CRC cis rs6502050 0.835 rs6502079 chr17:80124454 T/A cg22110888 chr17:80059540 CCDC57 0.4 6.38 0.33 5.96e-10 Life satisfaction; CRC cis rs9926296 0.656 rs11861084 chr16:89875710 G/T cg04287289 chr16:89883240 FANCA -0.6 -9.7 -0.47 9.91e-20 Vitiligo; CRC cis rs1862618 0.525 rs832403 chr5:56265992 G/T cg20203395 chr5:56204925 C5orf35 0.7 8.17 0.41 6.8e-15 Initial pursuit acceleration; CRC cis rs9443645 0.901 rs1538235 chr6:79689450 C/T cg09184832 chr6:79620586 NA -0.51 -9.38 -0.46 1.1e-18 Intelligence (multi-trait analysis); CRC cis rs2836974 0.681 rs8128827 chr21:40710547 C/T cg11644478 chr21:40555479 PSMG1 0.74 10.49 0.5 2.2e-22 Cognitive function; CRC cis rs6912958 0.781 rs4334949 chr6:88290150 G/A cg12350822 chr6:88032061 C6orf162;GJB7 -0.33 -6.25 -0.33 1.28e-9 Monocyte percentage of white cells; CRC cis rs4862750 0.872 rs6553029 chr4:187876470 G/T cg27532560 chr4:187881888 NA 0.53 9.47 0.46 5.86e-19 Lobe attachment (rater-scored or self-reported); CRC trans rs9693857 0.520 rs7830572 chr8:9356802 T/G cg06636001 chr8:8085503 FLJ10661 0.47 6.3 0.33 9.52e-10 Systolic blood pressure; CRC cis rs12620999 0.941 rs62183344 chr2:237979165 T/C cg23555395 chr2:238036564 NA 0.54 8.34 0.42 2.03e-15 Systemic lupus erythematosus; CRC cis rs6938 0.514 rs56338926 chr15:75259335 C/A cg21523564 chr15:75251491 NA 0.4 5.83 0.31 1.34e-8 Breast cancer; CRC cis rs9658691 0.646 rs7079111 chr10:90750982 T/G cg03111039 chr10:90751583 FAS;ACTA2 0.77 5.87 0.31 1.04e-8 Mosquito bite size; CRC cis rs7647973 1.000 rs892974 chr3:49398514 C/A cg07636037 chr3:49044803 WDR6 0.62 7.22 0.37 3.55e-12 Menarche (age at onset); CRC cis rs9768139 1.000 rs9768139 chr7:158120731 G/A cg23298862 chr7:158159286 PTPRN2 -0.48 -7.9 -0.4 4.22e-14 Calcium levels; CRC cis rs10504229 0.683 rs79262965 chr8:58129826 G/T cg11062466 chr8:58055876 NA 0.54 6.82 0.35 4.35e-11 Developmental language disorder (linguistic errors); CRC cis rs4803480 0.529 rs4803481 chr19:42066556 A/G cg08478046 chr19:42093086 CEACAM21 -0.28 -5.92 -0.31 7.88e-9 Schizophrenia; CRC cis rs76878669 0.561 rs7107191 chr11:66140397 G/A cg24851651 chr11:66362959 CCS -0.39 -6.77 -0.35 5.93e-11 Educational attainment (years of education); CRC cis rs10197940 0.624 rs10497082 chr2:152355258 T/C cg06191203 chr2:152266755 RIF1 -0.72 -10.35 -0.5 6.44e-22 Lung cancer; CRC cis rs6502050 0.871 rs11870632 chr17:80075406 T/C cg09264619 chr17:80180166 NA 0.36 5.92 0.31 8.27e-9 Life satisfaction; CRC cis rs853679 0.517 rs35227624 chr6:28132726 A/G cg15786705 chr6:28176104 NA 0.78 9.83 0.48 3.57e-20 Depression; CRC cis rs7224685 0.501 rs1377806 chr17:4019966 A/G cg09597638 chr17:3907349 NA 0.63 11.22 0.53 5.9e-25 Type 2 diabetes; CRC cis rs6502050 0.787 rs8080682 chr17:80058901 G/A cg13939156 chr17:80058883 NA 0.37 5.86 0.31 1.1e-8 Life satisfaction; CRC cis rs9311474 0.629 rs4282054 chr3:52566065 T/C cg05573699 chr3:52720067 GNL3;PBRM1 -0.44 -6.69 -0.35 9.4e-11 Electroencephalogram traits; CRC cis rs10924970 0.967 rs10495362 chr1:235390396 T/C cg26050004 chr1:235667680 B3GALNT2 0.39 5.79 0.3 1.64e-8 Asthma; CRC cis rs3733585 0.781 rs13103690 chr4:9972778 T/G cg11266682 chr4:10021025 SLC2A9 -0.48 -9.75 -0.47 6.69e-20 Cleft plate (environmental tobacco smoke interaction); CRC cis rs7927592 0.701 rs12226585 chr11:68257861 A/T cg16797656 chr11:68205561 LRP5 -0.47 -8.56 -0.43 4.51e-16 Total body bone mineral density; CRC cis rs7044106 0.762 rs4142158 chr9:123410819 C/T cg09419670 chr9:123605666 PSMD5;LOC253039 0.7 10.73 0.51 3.25e-23 Hip circumference adjusted for BMI; CRC cis rs3862030 0.694 rs41306870 chr10:104229785 C/T cg11453585 chr10:104263688 ACTR1A;SUFU -0.76 -13.31 -0.59 1.26e-32 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for body mass index; CRC cis rs62064224 0.791 rs2344977 chr17:30720573 C/G cg18200150 chr17:30822561 MYO1D 0.66 13.03 0.58 1.46e-31 Schizophrenia; CRC cis rs7615952 0.599 rs1875683 chr3:125732481 C/G cg04553112 chr3:125709451 NA -0.52 -5.97 -0.31 6.27e-9 Blood pressure (smoking interaction); CRC cis rs216303 1.000 rs216304 chr12:6159537 A/G cg19878637 chr12:6148451 VWF -0.55 -6.06 -0.32 3.73e-9 Low vWF levels; CRC cis rs3099143 1.000 rs1114717 chr15:77086078 A/G cg21673338 chr15:77095150 SCAPER 0.69 7.17 0.37 4.83e-12 Recalcitrant atopic dermatitis; CRC cis rs1799949 1.000 rs11653069 chr17:41283377 C/T cg25072359 chr17:41440525 NA 0.46 6.93 0.36 2.19e-11 Menopause (age at onset); CRC trans rs9840812 0.953 rs61791721 chr3:135804550 T/A cg17080335 chr12:131030206 NA 0.41 6.25 0.33 1.27e-9 Fibrinogen levels; CRC trans rs10982213 0.830 rs2274163 chr9:117188714 C/T cg27434351 chr11:14521491 COPB1 0.4 6.32 0.33 8.52e-10 Interleukin-6 levels; CRC cis rs9814567 1.000 rs10804632 chr3:134294501 T/A cg06109529 chr3:134205091 CEP63;ANAPC13 -0.8 -11.7 -0.54 1.13e-26 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs1580019 0.922 rs766658 chr7:32499391 C/T cg07520158 chr7:32535189 LSM5;AVL9 0.46 6.52 0.34 2.6e-10 Cognitive ability; CRC cis rs2072499 0.750 rs55910626 chr1:156159909 C/G cg24450063 chr1:156163899 SLC25A44 1.08 16.91 0.68 1.36e-46 Testicular germ cell tumor; CRC cis rs6540559 0.673 rs17015224 chr1:209968918 G/A cg22029157 chr1:209979665 IRF6 0.73 9.52 0.46 4e-19 Cleft lip with or without cleft palate; CRC cis rs2836974 0.739 rs12482181 chr21:40548852 A/G cg11644478 chr21:40555479 PSMG1 0.82 12.6 0.57 5.59e-30 Cognitive function; CRC cis rs1552244 0.554 rs2272122 chr3:10047975 C/G cg13047869 chr3:10149882 C3orf24 0.4 6.05 0.32 3.83e-9 Alzheimer's disease; CRC cis rs7811142 0.775 rs6946768 chr7:99954393 G/A cg00814883 chr7:100076585 TSC22D4 -0.72 -8.71 -0.43 1.48e-16 Platelet count; CRC cis rs3996993 0.809 rs6458879 chr6:52688783 G/C cg20803780 chr6:52668592 GSTA1 -0.39 -7.27 -0.37 2.62e-12 Hemoglobin concentration; CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg01750847 chr16:30007184 HIRIP3;INO80E 0.42 7.13 0.37 6.57e-12 Obesity-related traits; CRC cis rs898097 0.691 rs7222745 chr17:80907253 C/T cg03160526 chr17:80928410 B3GNTL1 -0.52 -8.68 -0.43 1.9e-16 Breast cancer; CRC cis rs9914988 1.000 rs9895443 chr17:27182944 A/G cg12682573 chr17:27188876 MIR451;MIR144 0.6 8.78 0.44 9.43e-17 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg21871583 chr3:15374148 SH3BP5 0.3 6.25 0.33 1.31e-9 Obesity-related traits; CRC cis rs6499129 1.000 rs8047159 chr16:67453634 T/A cg26727032 chr16:67993705 SLC12A4 -0.57 -6.73 -0.35 7.7e-11 Waist-to-hip ratio adjusted for body mass index; CRC trans rs11343 0.675 rs7359333 chr16:19262344 A/T cg08942682 chr3:197409980 KIAA0226 -0.47 -6.12 -0.32 2.71e-9 Parkinson's disease; CRC cis rs250677 1.000 rs250676 chr5:148425518 A/T cg23229984 chr5:148520753 ABLIM3 0.48 6.81 0.35 4.71e-11 Breast cancer; CRC trans rs7615952 1.000 rs7616044 chr3:125649354 G/C cg07211511 chr3:129823064 LOC729375 -1.07 -18.29 -0.71 4.77e-52 Blood pressure (smoking interaction); CRC cis rs9948 0.655 rs57582887 chr2:97406354 A/C cg20312557 chr2:97357134 FER1L5 -0.6 -5.61 -0.3 4.38e-8 Erectile dysfunction and prostate cancer treatment; CRC cis rs72634258 0.945 rs7517357 chr1:8025275 C/T cg26816564 chr1:7831052 VAMP3 0.56 6.04 0.32 4.12e-9 Inflammatory bowel disease; CRC cis rs7937682 0.921 rs4616071 chr11:111440865 C/G cg19812747 chr11:111475976 SIK2 0.52 7.58 0.39 3.46e-13 Primary sclerosing cholangitis; CRC cis rs6076065 0.723 rs2275787 chr20:23338486 A/G cg11657817 chr20:23433608 CST11 0.46 6.81 0.35 4.7e-11 Facial morphology (factor 15, philtrum width); CRC trans rs1455244 0.700 rs7229302 chr18:11508904 G/T cg17133724 chr18:22932450 ZNF521 0.38 6.12 0.32 2.63e-9 Schizophrenia; CRC cis rs79149102 0.579 rs3910748 chr15:75318652 A/G cg09165964 chr15:75287851 SCAMP5 -0.65 -6.18 -0.32 1.88e-9 Lung cancer; CRC cis rs8078723 0.677 rs8073254 chr17:38149350 C/G cg17344932 chr17:38183730 MED24;SNORD124 0.48 7.98 0.4 2.38e-14 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); CRC cis rs4466137 0.794 rs6869296 chr5:83007333 C/G cg16102102 chr5:83017553 HAPLN1 0.47 7.33 0.37 1.85e-12 Prostate cancer; CRC cis rs12681287 0.547 rs6471360 chr8:87513469 C/T cg27223183 chr8:87520930 FAM82B 0.5 7.12 0.37 6.81e-12 Caudate activity during reward; CRC cis rs2456568 0.778 rs2456563 chr11:93678675 C/T cg26875233 chr11:93583750 C11orf90 -0.31 -5.97 -0.31 6.19e-9 Response to serotonin reuptake inhibitors in major depressive disorder; CRC cis rs4713118 0.586 rs9468290 chr6:28087674 C/T cg18032046 chr6:28092343 ZSCAN16 -0.52 -6.02 -0.31 4.76e-9 Parkinson's disease; CRC cis rs12188164 0.686 rs72711367 chr5:418494 A/G cg26850624 chr5:429559 AHRR -0.76 -12.23 -0.56 1.32e-28 Cystic fibrosis severity; CRC cis rs8177253 0.798 rs9871148 chr3:133507509 T/C cg08048268 chr3:133502702 NA -0.43 -7.9 -0.4 4.32e-14 Iron status biomarkers; CRC cis rs2882667 0.690 rs167009 chr5:138200457 G/C cg09476006 chr5:138032270 NA -0.54 -8.92 -0.44 3.21e-17 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs7487075 0.820 rs12816413 chr12:46723289 T/C cg22049899 chr12:47219821 SLC38A4 0.33 6.34 0.33 7.36e-10 Itch intensity from mosquito bite; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg02842104 chr19:12251201 ZNF20 0.36 6.27 0.33 1.16e-9 Liver disease severity in Alagille syndrome; CRC cis rs478304 0.654 rs7115734 chr11:65458964 G/A cg05805236 chr11:65401703 PCNXL3 -0.41 -6.61 -0.34 1.59e-10 Acne (severe); CRC cis rs1552244 0.816 rs56387520 chr3:10042782 C/T cg18598329 chr3:10140678 FANCD2;C3orf24 -0.81 -10.69 -0.51 4.35e-23 Alzheimer's disease; CRC cis rs10504229 0.679 rs17800895 chr8:58050085 A/G cg02725872 chr8:58115012 NA -0.51 -7.09 -0.36 8.18e-12 Developmental language disorder (linguistic errors); CRC cis rs11190604 1.000 rs11190555 chr10:102209160 A/G cg16342193 chr10:102329863 NA -0.35 -5.83 -0.31 1.29e-8 Palmitoleic acid (16:1n-7) levels; CRC cis rs1218582 0.772 rs4845682 chr1:154877105 T/C cg24250549 chr1:154909240 PMVK 0.65 11.29 0.53 3.2e-25 Prostate cancer; CRC cis rs7811142 1.000 rs67163493 chr7:100023838 C/T cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.63 8.16 0.41 7.42e-15 Platelet count; CRC cis rs947211 0.950 rs885224 chr1:205753097 A/G cg24503407 chr1:205819492 PM20D1 0.46 6.35 0.33 7.26e-10 Parkinson's disease; CRC cis rs4660306 1.000 rs7522705 chr1:45992300 C/G cg03123370 chr1:45965343 CCDC163P;MMACHC 0.53 7.62 0.39 2.79e-13 Homocysteine levels; CRC cis rs7618915 0.547 rs34215106 chr3:52659124 T/C cg10802521 chr3:52805072 NEK4 -0.58 -8.98 -0.44 2.11e-17 Bipolar disorder; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg13265914 chr8:21999630 REEP4 0.41 6.17 0.32 1.97e-9 Intelligence (multi-trait analysis); CRC cis rs3733585 0.673 rs4235347 chr4:9951956 C/T cg00071950 chr4:10020882 SLC2A9 -0.55 -9.74 -0.47 7.09e-20 Cleft plate (environmental tobacco smoke interaction); CRC cis rs11734570 0.581 rs55958238 chr4:38604331 A/G cg18361445 chr4:38666374 KLF3;FLJ13197 0.62 7.96 0.4 2.73e-14 Inflammatory bowel disease;Crohn's disease; CRC cis rs11229555 0.645 rs35735990 chr11:58187371 G/A cg15696309 chr11:58395628 NA -0.82 -10.31 -0.49 8.59e-22 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; CRC trans rs2303319 0.504 rs62189051 chr2:162622318 G/A cg11326919 chr17:43324904 LOC100133991 -0.64 -5.99 -0.31 5.65e-9 Cognitive function; CRC trans rs1814175 0.615 rs10839378 chr11:49806943 C/T cg03929089 chr4:120376271 NA -0.9 -15.42 -0.65 9.69e-41 Height; CRC cis rs7811142 1.000 rs68116612 chr7:100006493 G/A cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.62 8.38 0.42 1.56e-15 Platelet count; CRC cis rs9368481 0.645 rs10456350 chr6:26975581 A/C cg18278486 chr6:26987575 LOC100270746;C6orf41 0.43 6.87 0.35 3.16e-11 Autism spectrum disorder or schizophrenia; CRC cis rs60871478 0.636 rs12532761 chr7:905229 C/T cg13798912 chr7:905769 UNC84A -0.64 -6.87 -0.35 3.27e-11 Cerebrospinal P-tau181p levels; CRC cis rs694739 1.000 rs646153 chr11:64089588 C/T cg02228329 chr11:64053129 BAD;GPR137 0.61 8.92 0.44 3.38e-17 Alopecia areata;Crohn's disease;Psoriasis vulgaris; CRC cis rs4253772 0.591 rs6007740 chr22:46654323 A/G cg24881330 chr22:46731750 TRMU -0.6 -7.0 -0.36 1.43e-11 LDL cholesterol;Cholesterol, total; CRC cis rs72634258 0.796 rs10746475 chr1:8168261 T/A cg26816564 chr1:7831052 VAMP3 -0.51 -6.15 -0.32 2.29e-9 Inflammatory bowel disease; CRC cis rs2274273 0.588 rs9919932 chr14:55814080 A/G cg10130446 chr14:55658398 DLGAP5 -0.42 -5.82 -0.31 1.4e-8 Protein biomarker; CRC cis rs28386778 0.897 rs2584627 chr17:61901439 T/C cg07362569 chr17:61921086 SMARCD2 0.37 5.66 0.3 3.23e-8 Prudent dietary pattern; CRC cis rs8105895 0.935 rs4257328 chr19:22240090 G/A cg02657401 chr19:22469223 NA -0.34 -5.65 -0.3 3.56e-8 Body mass index (change over time); CRC cis rs4665809 1.000 rs6720314 chr2:26334852 G/A cg04944784 chr2:26401820 FAM59B -0.66 -8.14 -0.41 8.04e-15 Gut microbiome composition (summer); CRC cis rs2243480 1.000 rs2707844 chr7:66059509 G/A cg12463550 chr7:65579703 CRCP 0.66 6.0 0.31 5.22e-9 Diabetic kidney disease; CRC cis rs3858526 0.917 rs9284148 chr11:5973185 G/C cg13902645 chr11:5959945 NA -0.64 -8.34 -0.42 2.01e-15 DNA methylation (variation); CRC cis rs4285028 0.948 rs34696871 chr3:121671880 T/G cg20356878 chr3:121714668 ILDR1 -0.48 -7.04 -0.36 1.12e-11 Multiple sclerosis; CRC cis rs2070677 0.736 rs12261564 chr10:135354594 C/T cg20169779 chr10:135381914 SYCE1 -0.69 -8.46 -0.42 9.21e-16 Gout; CRC trans rs1814175 0.645 rs847635 chr11:49923323 G/A cg11707556 chr5:10655725 ANKRD33B -0.52 -9.95 -0.48 1.49e-20 Height; CRC cis rs4917300 0.626 rs1388796 chr8:143096437 A/G cg25363559 chr8:143086065 NA -0.34 -6.35 -0.33 6.98e-10 Amyotrophic lateral sclerosis; CRC cis rs4638749 1.000 rs2219078 chr2:108875198 C/T cg25838818 chr2:108905173 SULT1C2 -0.37 -5.93 -0.31 7.68e-9 Blood pressure; CRC cis rs7618501 0.501 rs35275715 chr3:49959148 A/G cg24308560 chr3:49941425 MST1R -0.45 -7.06 -0.36 9.94e-12 Intelligence (multi-trait analysis); CRC cis rs8062405 0.929 rs11150609 chr16:28870596 A/G cg08761264 chr16:28874980 SH2B1 -0.44 -5.84 -0.31 1.27e-8 Cognitive ability (multi-trait analysis);Cognitive ability; CRC cis rs354225 0.584 rs7591231 chr2:54829596 C/G cg26097391 chr2:54893211 SPTBN1 0.41 6.11 0.32 2.8e-9 Schizophrenia; CRC cis rs9916302 0.768 rs11078900 chr17:37614641 C/T cg00129232 chr17:37814104 STARD3 -0.54 -8.06 -0.41 1.42e-14 Glomerular filtration rate (creatinine); CRC cis rs644799 0.525 rs3016206 chr11:95536724 T/C cg03916912 chr11:95522834 CEP57;FAM76B 0.85 15.83 0.66 2.4e-42 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs7617480 0.549 rs9879978 chr3:48846600 T/G cg20833759 chr3:49053208 WDR6;DALRD3 0.75 11.72 0.54 9.63e-27 Subjective well-being (multi-trait analysis);Menarche (age at onset); CRC cis rs514406 0.861 rs35517489 chr1:53304062 G/C cg27535305 chr1:53392650 SCP2 -0.37 -6.75 -0.35 6.77e-11 Monocyte count; CRC cis rs7044106 0.734 rs1981020 chr9:123388464 C/T cg09586646 chr9:123605570 PSMD5;LOC253039 0.63 9.51 0.46 4.25e-19 Hip circumference adjusted for BMI; CRC cis rs7615952 0.546 rs2979306 chr3:125312130 C/A cg11143507 chr3:125485238 NA -0.51 -5.61 -0.3 4.4e-8 Blood pressure (smoking interaction); CRC cis rs2115630 0.967 rs8028490 chr15:85277888 G/A cg09876464 chr15:85330779 ZNF592 0.45 7.61 0.39 2.9e-13 P wave terminal force; CRC cis rs12024301 0.557 rs7542316 chr1:183595222 A/G cg11505048 chr1:183622726 RGL1;APOBEC4 0.76 6.93 0.36 2.16e-11 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs1218582 0.804 rs869506 chr1:154859581 A/C cg16680214 chr1:154839983 KCNN3 -0.48 -9.49 -0.46 4.73e-19 Prostate cancer; CRC cis rs4750440 0.585 rs7072791 chr10:14028195 A/C cg00551146 chr10:14014579 FRMD4A 0.46 7.4 0.38 1.15e-12 Adiponectin levels; CRC trans rs7395662 0.553 rs11040122 chr11:48901038 A/G cg21153622 chr11:89784906 NA 0.46 7.18 0.37 4.56e-12 HDL cholesterol; CRC cis rs9787249 0.957 rs1046988 chr1:40219065 A/G cg02773041 chr1:40204384 PPIE -0.62 -9.27 -0.46 2.52e-18 Blood protein levels; CRC cis rs4243830 1.000 rs58415361 chr1:6592377 A/G cg22792644 chr1:6614718 TAS1R1;NOL9 0.75 7.1 0.36 7.91e-12 Body mass index; CRC cis rs6500395 0.962 rs9921737 chr16:48589873 G/T cg04672837 chr16:48644449 N4BP1 0.42 5.99 0.31 5.43e-9 Response to tocilizumab in rheumatoid arthritis; CRC cis rs1865760 0.568 rs2032450 chr6:25993114 C/G cg16482183 chr6:26056742 HIST1H1C 0.51 7.48 0.38 6.71e-13 Height; CRC cis rs12586317 0.582 rs731906 chr14:35604543 C/T cg16230307 chr14:35515116 FAM177A1 0.83 9.31 0.46 1.89e-18 Psoriasis; CRC trans rs10983614 1.000 rs7867776 chr9:120072627 A/G cg09144709 chr1:116915824 ATP1A1 0.45 6.23 0.32 1.47e-9 Survival in pancreatic cancer; CRC cis rs7216064 1.000 rs2365468 chr17:65841318 C/T cg12091567 chr17:66097778 LOC651250 -0.63 -7.77 -0.39 1.01e-13 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CRC cis rs11785693 0.862 rs62491196 chr8:4995690 C/T cg26367366 chr8:4980734 NA 0.79 9.53 0.47 3.55e-19 Neuroticism (multi-trait analysis);Neuroticism; CRC cis rs2735413 0.918 rs12918959 chr16:78081719 T/C cg04733911 chr16:78082701 NA -0.44 -7.37 -0.38 1.38e-12 Systolic blood pressure (alcohol consumption interaction); CRC cis rs9467711 0.651 rs13206443 chr6:26119245 C/T cg08501292 chr6:25962987 TRIM38 0.91 8.23 0.41 4.35e-15 Autism spectrum disorder or schizophrenia; CRC cis rs172166 0.694 rs1225716 chr6:28113746 A/C cg21251018 chr6:28226885 NKAPL 0.46 6.93 0.36 2.19e-11 Cardiac Troponin-T levels; CRC cis rs12144094 0.882 rs11577560 chr1:120229865 A/G cg20995928 chr1:120229863 NA 0.45 6.48 0.34 3.34e-10 Height; CRC cis rs7586879 0.828 rs7597157 chr2:25089166 C/T cg04586622 chr2:25135609 ADCY3 -0.55 -9.32 -0.46 1.68e-18 Body mass index; CRC cis rs6540559 0.673 rs11803382 chr1:209986426 G/A cg22029157 chr1:209979665 IRF6 0.72 9.5 0.46 4.34e-19 Cleft lip with or without cleft palate; CRC cis rs7615952 0.599 rs7652883 chr3:125707977 T/G cg04553112 chr3:125709451 NA -0.49 -5.74 -0.3 2.2e-8 Blood pressure (smoking interaction); CRC cis rs11958404 0.932 rs56204919 chr5:157431084 C/T cg05962755 chr5:157440814 NA 1.01 12.88 0.58 5.12e-31 IgG glycosylation; CRC cis rs6121246 0.559 rs6121243 chr20:30415094 C/G cg13852791 chr20:30311386 BCL2L1 0.77 15.46 0.65 6.37e-41 Mean corpuscular hemoglobin; CRC cis rs1153858 1.000 rs16942000 chr15:45633003 C/T cg21132104 chr15:45694354 SPATA5L1 0.57 8.46 0.42 8.9e-16 Homoarginine levels; CRC cis rs1957429 0.808 rs4899150 chr14:65344400 A/G cg23373153 chr14:65346875 NA 0.9 7.84 0.4 6.13e-14 Pediatric areal bone mineral density (radius); CRC cis rs2072499 0.750 rs72708291 chr1:156177285 A/T cg24450063 chr1:156163899 SLC25A44 1.04 16.67 0.68 1.18e-45 Testicular germ cell tumor; CRC cis rs1552244 0.515 rs67342818 chr3:10166406 G/A cg00166722 chr3:10149974 C3orf24 0.65 7.7 0.39 1.56e-13 Alzheimer's disease; CRC cis rs6062302 0.522 rs2282157 chr20:62227180 C/G cg16989086 chr20:62203971 PRIC285 0.47 6.03 0.32 4.52e-9 Glioblastoma; CRC cis rs12477438 1.000 rs1922624 chr2:99909958 A/G cg14399236 chr2:99771627 LIPT1;TSGA10 -0.72 -9.02 -0.45 1.64e-17 Chronic sinus infection; CRC cis rs228769 0.543 rs170634 chr17:42175821 C/A cg10896456 chr17:42255109 ASB16;C17orf65 -0.42 -6.76 -0.35 6.45e-11 Bone mineral density (hip);Bone mineral density (spine); CRC cis rs9910055 0.502 rs1684662 chr17:42180822 T/A cg09913183 chr17:42254507 C17orf65;ASB16 -0.5 -6.81 -0.35 4.53e-11 Total body bone mineral density; CRC cis rs4880487 0.888 rs7074199 chr10:1251022 C/T cg03183215 chr10:1252341 ADARB2 -0.3 -6.31 -0.33 8.86e-10 Migraine; CRC trans rs11098499 0.562 rs13101722 chr4:120555975 C/A cg25214090 chr10:38739885 LOC399744 -0.52 -8.31 -0.42 2.49e-15 Corneal astigmatism; CRC trans rs9929218 1.000 rs9936621 chr16:68798682 A/G cg04657470 chr2:198365150 HSPE1;HSPD1 -0.84 -11.95 -0.55 1.42e-27 Colorectal cancer; CRC cis rs200986 1 rs200986 chr6:27824766 G/C cg15786705 chr6:28176104 NA 0.55 7.73 0.39 1.28e-13 Autism spectrum disorder or schizophrenia; CRC cis rs72781680 0.611 rs7596820 chr2:24335036 G/C cg20701182 chr2:24300061 SF3B14 0.61 7.43 0.38 9.64e-13 Lymphocyte counts; CRC cis rs7615952 0.599 rs7631268 chr3:125755664 T/A cg15145296 chr3:125709740 NA -0.57 -6.5 -0.34 2.98e-10 Blood pressure (smoking interaction); CRC cis rs17152411 1.000 rs12573033 chr10:126607803 T/G cg07906193 chr10:126599966 NA 0.57 6.43 0.33 4.38e-10 Height; CRC cis rs6582630 0.555 rs10880607 chr12:38508184 A/G cg26384229 chr12:38710491 ALG10B 0.71 9.54 0.47 3.27e-19 Drug-induced liver injury (flucloxacillin); CRC cis rs10486722 0.607 rs1003291 chr7:41750087 G/A cg22138096 chr7:41772439 LOC285954 0.69 8.18 0.41 6.32e-15 Pit-and-Fissure caries; CRC cis rs9309711 0.666 rs6767 chr2:3483205 C/T cg08493051 chr2:3487164 NA -0.39 -5.71 -0.3 2.53e-8 Neurofibrillary tangles; CRC trans rs116095464 0.558 rs10067021 chr5:221490 C/T cg00938859 chr5:1591904 SDHAP3 0.68 7.39 0.38 1.24e-12 Breast cancer; CRC cis rs12928939 0.518 rs12445564 chr16:71943309 C/T cg03805757 chr16:71968109 PKD1L3 -0.59 -7.81 -0.4 7.82e-14 Post bronchodilator FEV1; CRC cis rs916888 0.647 rs199449 chr17:44808902 G/A cg15921436 chr17:44337874 NA 0.53 6.83 0.35 4.04e-11 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs6963495 0.818 rs73192145 chr7:105203628 A/C cg13798780 chr7:105162888 PUS7 0.64 7.32 0.37 1.91e-12 Bipolar disorder (body mass index interaction); CRC cis rs2243480 1.000 rs419603 chr7:65597341 C/T cg12463550 chr7:65579703 CRCP 0.69 6.4 0.33 5.42e-10 Diabetic kidney disease; CRC cis rs1395 0.744 rs57881048 chr2:27474165 T/C cg23587288 chr2:27483067 SLC30A3 -0.4 -6.74 -0.35 7.29e-11 Blood metabolite levels; CRC cis rs7493 0.901 rs17879517 chr7:95030646 T/C cg07404485 chr7:94953653 PON1 -0.44 -5.83 -0.31 1.3e-8 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs7811142 0.830 rs6945952 chr7:99981775 A/G cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.73 10.01 0.48 9.43e-21 Platelet count; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg01705458 chr11:27384997 CCDC34 0.46 5.98 0.31 5.83e-9 Anxiety disorder; CRC cis rs400736 0.894 rs226253 chr1:8027706 T/C cg25007680 chr1:8021821 PARK7 0.56 7.6 0.39 3.13e-13 Response to antidepressants and depression; CRC cis rs9291683 0.551 rs2240720 chr4:10020480 C/T cg00071950 chr4:10020882 SLC2A9 0.68 13.34 0.59 9.15e-33 Bone mineral density; CRC cis rs1018836 0.828 rs1858673 chr8:91551526 C/A cg16814680 chr8:91681699 NA -0.61 -9.39 -0.46 1.06e-18 Ejection fraction in Tripanosoma cruzi seropositivity; CRC cis rs7707921 0.881 rs2629744 chr5:81381997 A/T cg07807695 chr5:81608485 ATP6AP1L 0.41 6.06 0.32 3.75e-9 Breast cancer; CRC cis rs2070997 0.702 rs11792273 chr9:133754032 A/G cg01000188 chr9:133769184 QRFP 0.56 5.9 0.31 9.07e-9 Response to amphetamines; CRC cis rs28386778 0.830 rs67905415 chr17:61841236 G/A cg22520471 chr17:61851767 DDX42;CCDC47 0.74 11.62 0.54 2.25e-26 Prudent dietary pattern; CRC cis rs728616 0.867 rs723193 chr10:81708155 G/T cg11900509 chr10:81946545 ANXA11 -0.63 -6.43 -0.33 4.58e-10 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs4147929 0.553 rs4147936 chr19:1065197 G/C cg26576206 chr19:1064938 ABCA7 0.42 5.96 0.31 6.6e-9 Alzheimer's disease (late onset); CRC cis rs1799949 1.000 rs915945 chr17:41179864 C/T cg19454999 chr17:41278357 BRCA1;NBR2 0.52 7.85 0.4 6.07e-14 Menopause (age at onset); CRC cis rs10504229 0.683 rs16921807 chr8:58105967 C/T cg22535103 chr8:58192502 C8orf71 -0.69 -8.8 -0.44 7.79e-17 Developmental language disorder (linguistic errors); CRC cis rs1881797 1.000 rs12061460 chr1:247686787 G/A cg18198730 chr1:247681584 NA 0.54 8.43 0.42 1.08e-15 Acute lymphoblastic leukemia (childhood); CRC cis rs9515201 0.627 rs952359 chr13:111026734 G/A cg06243866 chr13:111019493 COL4A2 -0.39 -5.99 -0.31 5.6e-9 White matter hyperintensity burden; CRC cis rs28386778 0.897 rs2665797 chr17:61922485 C/G cg11494091 chr17:61959527 GH2 -0.59 -10.15 -0.49 3.12e-21 Prudent dietary pattern; CRC cis rs12541635 0.677 rs13439705 chr8:106967268 T/C cg10147462 chr8:107024639 NA 0.57 9.42 0.46 8e-19 Age of smoking initiation; CRC cis rs7666738 0.753 rs11932536 chr4:98930105 A/G cg05340658 chr4:99064831 C4orf37 0.6 9.35 0.46 1.41e-18 Colonoscopy-negative controls vs population controls; CRC cis rs9527 0.590 rs10509764 chr10:104776475 G/A cg15744005 chr10:104629667 AS3MT -0.3 -5.95 -0.31 6.96e-9 Arsenic metabolism; CRC cis rs6743226 0.870 rs4675966 chr2:242244342 T/C cg10021735 chr2:242295487 FARP2 0.46 6.57 0.34 1.94e-10 Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI in non-smokers; CRC trans rs10506458 0.915 rs60094497 chr12:63394838 T/G cg03429785 chr15:59498649 MYO1E;LDHAL6B -1.45 -21.36 -0.76 3.94e-64 Hemostatic factors and hematological phenotypes; CRC cis rs3806843 0.548 rs246052 chr5:140326413 G/A cg19875535 chr5:140030758 IK 0.39 6.02 0.31 4.67e-9 Depressive symptoms (multi-trait analysis); CRC trans rs7618501 0.902 rs7645061 chr3:49868842 C/T cg21582582 chr3:182698605 DCUN1D1 0.54 7.98 0.4 2.43e-14 Intelligence (multi-trait analysis); CRC cis rs995000 0.931 rs1168044 chr1:62977558 A/C cg19896129 chr1:63156450 NA -0.44 -6.86 -0.35 3.42e-11 Triglyceride levels; CRC cis rs4727027 0.651 rs12704068 chr7:148856153 T/C cg23583168 chr7:148888333 NA -0.8 -12.19 -0.56 1.91e-28 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC cis rs13108904 0.518 rs4974602 chr4:1342391 C/T cg23123621 chr4:1343375 KIAA1530 0.38 6.07 0.32 3.46e-9 Obesity-related traits; CRC trans rs2228479 0.850 rs2238527 chr16:89840708 C/A cg21302420 chr1:112162376 RAP1A 0.72 5.96 0.31 6.33e-9 Skin colour saturation; CRC cis rs875971 0.862 rs9791712 chr7:66105163 C/G cg18876405 chr7:65276391 NA -0.53 -8.5 -0.42 6.79e-16 Aortic root size; CRC cis rs8060686 0.925 rs9928531 chr16:67833171 T/C cg00318322 chr16:67708822 GFOD2 -0.32 -5.96 -0.31 6.51e-9 HDL cholesterol;Metabolic syndrome; CRC cis rs1862618 0.713 rs832549 chr5:56183542 C/T cg12311346 chr5:56204834 C5orf35 -0.79 -10.04 -0.48 7.48e-21 Initial pursuit acceleration; CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg02056921 chr1:901892 PLEKHN1 -0.51 -6.46 -0.34 3.82e-10 Diisocyanate-induced asthma; CRC cis rs12530845 0.673 rs73721607 chr7:135335822 C/T cg23117316 chr7:135346802 PL-5283 -0.45 -5.82 -0.31 1.38e-8 Red blood cell traits; CRC trans rs9929218 0.581 rs7203337 chr16:68774800 C/G cg04657470 chr2:198365150 HSPE1;HSPD1 0.96 17.88 0.7 1.95e-50 Colorectal cancer; CRC cis rs2243480 1.000 rs56291018 chr7:65390339 G/A cg18252515 chr7:66147081 NA -1.07 -12.34 -0.56 5.05e-29 Diabetic kidney disease; CRC cis rs9486715 0.809 rs9486467 chr6:96971803 C/T cg06623918 chr6:96969491 KIAA0776 1.03 20.96 0.76 1.52e-62 Headache; CRC cis rs936229 0.798 rs1869959 chr15:75147332 A/C cg10253484 chr15:75165896 SCAMP2 -0.42 -6.44 -0.33 4.25e-10 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); CRC cis rs7635838 0.718 rs2594973 chr3:11395821 C/G cg00170343 chr3:11313890 ATG7 0.46 7.07 0.36 9.57e-12 HDL cholesterol; CRC cis rs7177699 0.557 rs55870734 chr15:79117917 A/T cg15571903 chr15:79123663 NA -0.31 -6.08 -0.32 3.34e-9 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; CRC cis rs10791097 0.592 rs4936122 chr11:130734264 A/C cg12179176 chr11:130786555 SNX19 0.75 12.28 0.56 8.63e-29 Autism spectrum disorder or schizophrenia;Schizophrenia; CRC cis rs6712932 0.925 rs10210149 chr2:105839324 C/T cg20265528 chr2:105853269 NA -0.34 -5.74 -0.3 2.1e-8 Type 2 diabetes; CRC cis rs6952808 0.691 rs2398709 chr7:2112548 C/T cg21782813 chr7:2030301 MAD1L1 0.53 8.88 0.44 4.29e-17 Bipolar disorder and schizophrenia; CRC trans rs9561329 0.800 rs12865188 chr13:94034234 G/A cg23072629 chr2:239195537 PER2 0.32 6.01 0.31 5.03e-9 Neuroticism (age interaction); CRC cis rs9322193 0.923 rs9800614 chr6:149965740 G/A cg07701084 chr6:150067640 NUP43 0.56 8.15 0.41 7.9e-15 Lung cancer; CRC cis rs6502050 0.769 rs11658272 chr17:80084596 C/T cg11859384 chr17:80120422 CCDC57 0.37 5.82 0.31 1.36e-8 Life satisfaction; CRC cis rs12190007 0.547 rs2981945 chr6:169819839 G/A cg15038512 chr6:170123185 PHF10 -0.37 -5.73 -0.3 2.28e-8 Obesity-related traits; CRC cis rs709400 0.859 rs7154948 chr14:104022944 C/T cg01849466 chr14:104193079 ZFYVE21 0.41 6.44 0.33 4.16e-10 Body mass index; CRC cis rs10504229 0.512 rs117968470 chr8:58014651 C/G cg02725872 chr8:58115012 NA -0.52 -7.24 -0.37 3.13e-12 Developmental language disorder (linguistic errors); CRC cis rs9304742 0.646 rs10408610 chr19:53463913 G/A cg09915433 chr19:53449742 NA -0.51 -7.33 -0.37 1.76e-12 Psoriasis; CRC cis rs9467711 0.591 rs13220488 chr6:25896907 A/G cg19084075 chr6:26124329 HIST1H2AC;HIST1H2BC 0.75 5.78 0.3 1.72e-8 Autism spectrum disorder or schizophrenia; CRC cis rs4563143 0.675 rs55976444 chr19:29265214 G/C cg14983838 chr19:29218262 NA 0.46 6.76 0.35 6.47e-11 Methadone dose in opioid dependence; CRC cis rs9303280 0.806 rs4795400 chr17:38067020 C/T cg17467752 chr17:38218738 THRA -0.38 -5.63 -0.3 3.87e-8 Self-reported allergy; CRC trans rs6952808 0.771 rs10950415 chr7:1914477 A/G cg04565464 chr8:145669602 NFKBIL2 0.41 6.38 0.33 6.08e-10 Bipolar disorder and schizophrenia; CRC cis rs1707322 0.752 rs12027622 chr1:46130252 A/C cg03146154 chr1:46216737 IPP 0.66 9.65 0.47 1.44e-19 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC trans rs72956618 0.715 rs72933222 chr2:207319653 C/T cg13699355 chr2:468179 NA -0.63 -6.07 -0.32 3.43e-9 Tonsillectomy; CRC cis rs2549003 1.000 rs7734334 chr5:131815004 C/A cg21138405 chr5:131827807 IRF1 0.57 11.37 0.53 1.67e-25 Asthma (sex interaction); CRC cis rs1707322 0.721 rs28817701 chr1:46186050 C/T cg06784218 chr1:46089804 CCDC17 0.66 12.27 0.56 9.04e-29 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs35306767 0.714 rs67696450 chr10:1090684 C/T cg26597838 chr10:835615 NA 0.82 9.46 0.46 6.06e-19 Eosinophil percentage of granulocytes; CRC cis rs8180040 0.764 rs11708451 chr3:47198826 G/A cg02527881 chr3:46936655 PTH1R -0.4 -7.44 -0.38 8.8e-13 Colorectal cancer; CRC cis rs8062405 1.000 rs62036624 chr16:28839930 G/T cg08761264 chr16:28874980 SH2B1 -0.42 -5.63 -0.3 3.83e-8 Cognitive ability (multi-trait analysis);Cognitive ability; CRC cis rs1707322 0.717 rs2275086 chr1:46085879 C/G cg03146154 chr1:46216737 IPP -0.66 -9.39 -0.46 1.07e-18 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs72781680 1.000 rs72781667 chr2:24225667 A/G cg08917208 chr2:24149416 ATAD2B 0.89 8.73 0.43 1.32e-16 Lymphocyte counts; CRC cis rs1223397 0.651 rs449727 chr6:13296310 A/G cg07912922 chr6:13274314 PHACTR1 0.37 5.72 0.3 2.4e-8 Blood pressure; CRC cis rs28386778 0.897 rs4968598 chr17:61835579 T/C cg06873352 chr17:61820015 STRADA 0.76 14.29 0.62 2.25e-36 Prudent dietary pattern; CRC cis rs6940638 0.531 rs12211984 chr6:26986054 G/C cg05192639 chr6:26864778 GUSBL1 0.31 6.01 0.31 5.05e-9 Intelligence (multi-trait analysis); CRC cis rs4332037 0.802 rs73048106 chr7:1929019 G/T cg21155852 chr7:2048760 MAD1L1 -0.51 -6.9 -0.36 2.76e-11 Bipolar disorder; CRC cis rs3820068 0.581 rs72645874 chr1:15926238 C/G cg27534772 chr1:16042836 PLEKHM2 0.54 10.49 0.5 2.13e-22 Systolic blood pressure; CRC cis rs6681460 0.966 rs4655506 chr1:67150811 C/T cg02459107 chr1:67143332 SGIP1 0.41 7.19 0.37 4.5e-12 Presence of antiphospholipid antibodies; CRC cis rs1552244 0.688 rs7645137 chr3:10020549 A/AT cg08888203 chr3:10149979 C3orf24 0.64 8.56 0.43 4.5e-16 Alzheimer's disease; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg16196087 chr6:146135442 FBXO30 0.38 5.97 0.31 6.21e-9 Intelligence (multi-trait analysis); CRC cis rs4908768 0.501 rs1922983 chr1:8531326 A/G cg20416874 chr1:8611966 RERE -0.42 -5.84 -0.31 1.22e-8 Neuroticism (multi-trait analysis);Subjective well-being (multi-trait analysis); CRC cis rs7618915 0.547 rs4687548 chr3:52666650 A/T cg05573699 chr3:52720067 GNL3;PBRM1 -0.46 -6.52 -0.34 2.59e-10 Bipolar disorder; CRC cis rs7786877 0.680 rs28584500 chr7:100216341 G/A cg00334542 chr7:100209784 MOSPD3 -0.69 -7.91 -0.4 4e-14 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs72615157 0.606 rs941288 chr7:99776808 G/A cg13153964 chr7:100026424 MEPCE;ZCWPW1 0.76 9.03 0.45 1.49e-17 Lung function (FEV1/FVC); CRC cis rs4819052 0.851 rs914214 chr21:46697820 G/T cg02159808 chr21:46707872 POFUT2;LOC642852 0.51 6.71 0.35 8.75e-11 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC trans rs7027930 0.520 rs10975385 chr9:607178 C/G cg01026373 chr5:141071769 NA 0.5 5.97 0.31 6.2e-9 Pulmonary function decline; CRC cis rs2075371 0.863 rs1646638 chr7:134008706 T/C cg20476274 chr7:133979776 SLC35B4 0.71 12.13 0.56 3.08e-28 Mean platelet volume; CRC cis rs9611565 0.512 rs139566 chr22:42199277 A/G cg17554472 chr22:41940697 POLR3H -0.57 -5.82 -0.31 1.37e-8 Vitiligo; CRC trans rs2243480 1.000 rs387676 chr7:65598220 C/T cg10756647 chr7:56101905 PSPH 0.74 7.74 0.39 1.23e-13 Diabetic kidney disease; CRC cis rs4285028 0.747 rs12634032 chr3:121524575 G/A cg11130432 chr3:121712080 ILDR1 -0.54 -6.31 -0.33 9.1e-10 Multiple sclerosis; CRC cis rs2075371 1.000 rs2075373 chr7:133984683 A/C cg02659138 chr7:134003124 SLC35B4 0.4 6.96 0.36 1.84e-11 Mean platelet volume; CRC trans rs10982213 0.830 rs2274163 chr9:117188714 C/T cg04577441 chr4:100870687 LOC256880;H2AFZ -0.41 -6.13 -0.32 2.55e-9 Interleukin-6 levels; CRC cis rs709400 0.628 rs6575983 chr14:103869849 C/G cg12935359 chr14:103987150 CKB -0.48 -7.85 -0.4 5.87e-14 Body mass index; CRC cis rs67478160 0.619 rs28698555 chr14:104316486 C/A cg08213375 chr14:104286397 PPP1R13B -0.64 -13.25 -0.59 2.01e-32 Schizophrenia; CRC cis rs2179367 0.959 rs4895788 chr6:149748091 G/A cg11245181 chr6:149772854 ZC3H12D -0.38 -5.79 -0.3 1.68e-8 Dupuytren's disease; CRC cis rs1707322 1.000 rs11211219 chr1:46359478 G/C cg03146154 chr1:46216737 IPP 0.51 7.16 0.37 5.35e-12 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs7131987 0.845 rs2042511 chr12:29408780 C/T cg09582351 chr12:29534625 ERGIC2 -0.32 -6.82 -0.35 4.48e-11 QT interval; CRC cis rs1801251 1.000 rs991873 chr2:233711046 A/G cg25237894 chr2:233734115 C2orf82 -0.54 -8.79 -0.44 8.63e-17 Coronary artery disease; CRC trans rs2727020 0.857 rs1917324 chr11:49371759 G/C cg03929089 chr4:120376271 NA -0.72 -9.64 -0.47 1.55e-19 Coronary artery disease; CRC cis rs2239547 0.563 rs6445547 chr3:52908577 T/C cg18404041 chr3:52824283 ITIH1 -0.36 -6.68 -0.35 9.91e-11 Schizophrenia; CRC cis rs832540 0.593 rs96844 chr5:56196604 G/A cg24531977 chr5:56204891 C5orf35 -0.53 -7.87 -0.4 5.12e-14 Coronary artery disease; CRC cis rs7493 0.901 rs11764079 chr7:95026229 A/G cg04155289 chr7:94953770 PON1 0.52 7.54 0.38 4.49e-13 Yu-Zhi constitution type in type 2 diabetes; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg16473141 chr14:24641501 REC8 0.2 6.01 0.31 5.05e-9 Liver disease severity in Alagille syndrome; CRC cis rs2302190 0.882 rs11650105 chr17:56588072 C/T cg12560992 chr17:57184187 TRIM37 0.52 6.14 0.32 2.37e-9 Vitamin D levels; CRC cis rs9467711 0.591 rs6903228 chr6:25903047 A/G cg08501292 chr6:25962987 TRIM38 0.99 9.48 0.46 5.43e-19 Autism spectrum disorder or schizophrenia; CRC cis rs5750830 0.594 rs9611169 chr22:39783027 C/T cg25956985 chr22:39795188 MAP3K7IP1 -0.41 -5.86 -0.31 1.12e-8 Intelligence (multi-trait analysis); CRC cis rs1018836 0.884 rs2073640 chr8:91594853 A/G cg16814680 chr8:91681699 NA -0.72 -11.42 -0.53 1.12e-25 Ejection fraction in Tripanosoma cruzi seropositivity; CRC trans rs7395662 0.548 rs4882000 chr11:48546496 A/G cg21153622 chr11:89784906 NA -0.51 -8.55 -0.43 4.71e-16 HDL cholesterol; CRC cis rs11997175 0.646 rs2006792 chr8:33694423 G/A ch.8.33884649F chr8:33765107 NA 0.46 6.68 0.35 1.01e-10 Body mass index; CRC trans rs11098499 0.863 rs2170276 chr4:120485824 A/C cg25214090 chr10:38739885 LOC399744 0.66 10.41 0.5 4.04e-22 Corneal astigmatism; CRC cis rs1552244 1.000 rs56394721 chr3:10150795 A/G cg10729496 chr3:10149963 C3orf24 0.55 7.14 0.37 6.2e-12 Alzheimer's disease; CRC cis rs9341808 0.539 rs2490253 chr6:80895870 T/C cg08355045 chr6:80787529 NA 0.34 5.79 0.3 1.6e-8 Sitting height ratio; CRC cis rs4665809 0.680 rs3955310 chr2:26290828 T/G cg26119090 chr2:26468346 HADHA;HADHB -0.61 -7.8 -0.4 8.23e-14 Gut microbiome composition (summer); CRC trans rs2553218 0.690 rs8032415 chr15:54851945 A/G cg24806503 chr7:135194850 CNOT4 0.45 6.13 0.32 2.49e-9 Immune response to smallpox vaccine (IL-6); CRC trans rs8123881 0.733 rs7268466 chr20:15810676 C/T cg14695609 chr3:45430048 LARS2 0.56 6.07 0.32 3.51e-9 Body mass index; CRC cis rs73200209 0.912 rs11612304 chr12:116517704 C/T cg01776926 chr12:116560359 MED13L 0.49 6.1 0.32 2.95e-9 Total body bone mineral density; CRC cis rs9837602 0.507 rs1059905 chr3:99516879 A/T cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G -0.44 -6.19 -0.32 1.84e-9 Breast cancer; CRC cis rs7927771 0.524 rs7943464 chr11:47886639 T/A cg20307385 chr11:47447363 PSMC3 0.45 6.64 0.34 1.33e-10 Subjective well-being; CRC cis rs3768617 0.510 rs10797835 chr1:183072908 T/C ch.1.3577855R chr1:183094577 LAMC1 0.87 15.32 0.65 2.39e-40 Fuchs's corneal dystrophy; CRC cis rs1355223 0.583 rs1549789 chr11:34867947 G/A cg11058730 chr11:34937778 PDHX;APIP 0.73 11.82 0.55 4.03e-27 Systemic lupus erythematosus and Systemic sclerosis; CRC trans rs2228479 0.717 rs2270460 chr16:89972416 C/A cg24644049 chr4:85504048 CDS1 0.75 7.48 0.38 6.78e-13 Skin colour saturation; CRC cis rs7527798 0.545 rs6696228 chr1:207846830 G/A cg09232269 chr1:207846808 CR1L -0.5 -7.76 -0.39 1.05e-13 Erythrocyte sedimentation rate; CRC cis rs34172651 0.917 rs8049667 chr16:24773524 G/A cg06028605 chr16:24865363 SLC5A11 0.45 8.34 0.42 2.09e-15 Intelligence (multi-trait analysis); CRC cis rs9322193 0.923 rs56397000 chr6:150060483 C/T cg00933542 chr6:150070202 PCMT1 0.32 6.57 0.34 1.94e-10 Lung cancer; CRC cis rs16867321 0.694 rs4666853 chr2:181439671 C/T cg23363182 chr2:181467187 NA 0.6 9.22 0.45 3.63e-18 Obesity; CRC cis rs2535633 0.631 rs6799185 chr3:53101580 C/T cg15147215 chr3:52552868 STAB1 -0.45 -7.39 -0.38 1.22e-12 Body mass index; CRC cis rs1552244 0.626 rs2886396 chr3:10037670 C/T cg13047869 chr3:10149882 C3orf24 0.51 6.97 0.36 1.74e-11 Alzheimer's disease; CRC cis rs910316 0.737 rs175072 chr14:75502827 T/C cg03030879 chr14:75389066 RPS6KL1 0.45 7.16 0.37 5.36e-12 Height; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg06833562 chr1:86174060 ZNHIT6 0.49 6.89 0.36 2.76e-11 Response to antipsychotic treatment; CRC cis rs1552244 0.510 rs13075308 chr3:10034925 G/C cg16606324 chr3:10149918 C3orf24 0.62 8.08 0.41 1.25e-14 Alzheimer's disease; CRC cis rs7827545 1.000 rs1372659 chr8:135566779 T/A cg17885191 chr8:135476712 NA 0.52 7.03 0.36 1.18e-11 Hypertension (SNP x SNP interaction); CRC cis rs875971 1.000 rs55962648 chr7:65625751 C/G cg18912574 chr7:65842487 NCRNA00174 -0.37 -6.5 -0.34 3e-10 Aortic root size; CRC cis rs798554 1.000 rs798540 chr7:2764130 G/A cg19717773 chr7:2847554 GNA12 -0.41 -5.82 -0.31 1.43e-8 Height; CRC cis rs13191362 1.000 rs34653853 chr6:163114362 C/T cg06582575 chr6:163149167 PACRG;PARK2 0.93 11.8 0.55 4.74e-27 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs736408 0.812 rs4687654 chr3:52827566 G/A cg11645453 chr3:52864694 ITIH4 0.42 7.05 0.36 1.06e-11 Bipolar disorder; CRC cis rs4964805 0.626 rs4964827 chr12:104177081 G/T cg02344784 chr12:104178138 NT5DC3 0.54 7.99 0.4 2.36e-14 Attention deficit hyperactivity disorder; CRC cis rs9837602 1.000 rs7616988 chr3:99701134 G/A cg07805332 chr3:99536008 MIR548G;C3orf26 0.5 6.71 0.35 8.37e-11 Breast cancer; CRC cis rs9733 0.596 rs11204687 chr1:150629880 C/A cg10589385 chr1:150898437 SETDB1 0.28 5.98 0.31 5.86e-9 Tonsillectomy; CRC cis rs3857536 0.611 rs7748258 chr6:66932840 A/G cg07460842 chr6:66804631 NA -0.42 -5.7 -0.3 2.64e-8 Blood trace element (Cu levels); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg14576681 chr2:42588304 COX7A2L 0.45 6.38 0.33 6.17e-10 Response to antipsychotic treatment; CRC cis rs7312774 0.618 rs4964195 chr12:107392778 T/C cg16260113 chr12:107380972 MTERFD3 0.88 7.19 0.37 4.35e-12 Severe influenza A (H1N1) infection; CRC cis rs9894429 0.738 rs8077038 chr17:79577127 T/G cg21028142 chr17:79581711 NPLOC4 -0.33 -6.96 -0.36 1.81e-11 Eye color traits; CRC cis rs875971 1.000 rs6956179 chr7:65806659 C/T cg18876405 chr7:65276391 NA -0.54 -9.5 -0.46 4.61e-19 Aortic root size; CRC trans rs9291683 0.552 rs10939655 chr4:10014642 A/T cg26043149 chr18:55253948 FECH 0.51 7.92 0.4 3.73e-14 Bone mineral density; CRC trans rs2303319 0.504 rs62189052 chr2:162623869 C/G cg20024234 chr21:43431083 ZNF295 -0.66 -5.96 -0.31 6.5e-9 Cognitive function; CRC cis rs1003719 0.788 rs9977602 chr21:38450650 G/T cg10648535 chr21:38446584 PIGP;TTC3 0.53 7.53 0.38 4.9e-13 Eye color traits; CRC cis rs798554 1.000 rs798540 chr7:2764130 G/A cg04166393 chr7:2884313 GNA12 0.51 6.89 0.35 2.92e-11 Height; CRC cis rs66887589 0.837 rs6534135 chr4:120406302 A/G cg09307838 chr4:120376055 NA 0.55 8.48 0.42 7.78e-16 Diastolic blood pressure; CRC cis rs7811142 1.000 rs7809801 chr7:100072031 T/C cg00814883 chr7:100076585 TSC22D4 -0.74 -9.58 -0.47 2.55e-19 Platelet count; CRC cis rs9399135 0.967 rs1023179 chr6:135343829 T/A cg22676075 chr6:135203613 NA 0.4 6.25 0.33 1.27e-9 Red blood cell count; CRC cis rs875971 0.545 rs1547529 chr7:65723846 T/C cg03233332 chr7:66118400 NA -0.45 -6.3 -0.33 9.52e-10 Aortic root size; CRC trans rs925098 0.577 rs2724470 chr4:17996046 A/G cg25858983 chr17:42295711 UBTF -0.41 -6.31 -0.33 8.87e-10 Birth weight;Height; CRC cis rs3026445 0.742 rs2339524 chr12:111116655 T/C cg12870014 chr12:110450643 ANKRD13A 0.39 5.91 0.31 8.74e-9 QT interval; CRC cis rs9916302 0.821 rs1966915 chr17:37425262 A/C cg15445000 chr17:37608096 MED1 0.42 9.24 0.45 3.16e-18 Glomerular filtration rate (creatinine); CRC cis rs10504229 1.000 rs17217033 chr8:58180061 G/T cg24829409 chr8:58192753 C8orf71 -0.68 -11.34 -0.53 2.27e-25 Developmental language disorder (linguistic errors); CRC cis rs7666738 0.830 rs6831219 chr4:98993576 C/A cg05340658 chr4:99064831 C4orf37 0.61 9.54 0.47 3.44e-19 Colonoscopy-negative controls vs population controls; CRC cis rs6951245 1.000 rs80031817 chr7:1096793 T/C cg24642844 chr7:1081250 C7orf50 -0.78 -9.44 -0.46 7.23e-19 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs2576037 0.796 rs2571032 chr18:44578250 T/A cg20875182 chr18:44561130 TCEB3B;KATNAL2 -0.46 -7.3 -0.37 2.14e-12 Personality dimensions; CRC trans rs1728785 1.000 rs1069288 chr16:68585285 C/G cg04657470 chr2:198365150 HSPE1;HSPD1 0.57 6.92 0.36 2.41e-11 Ulcerative colitis; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg16136385 chr11:46848389 CKAP5 0.41 6.79 0.35 5.34e-11 Liver disease severity in Alagille syndrome; CRC cis rs1005224 0.963 rs12887886 chr14:76167846 C/T cg25116370 chr14:76127843 TTLL5;C14orf1 -0.38 -5.8 -0.3 1.56e-8 Large artery stroke; CRC trans rs771998 0.820 rs61914027 chr12:52343231 C/A cg04286455 chr5:77803462 LHFPL2 -0.44 -6.13 -0.32 2.52e-9 Post bronchodilator FEV1/FVC ratio; CRC cis rs10779751 1.000 rs2016559 chr1:11269917 G/T cg08854313 chr1:11322531 MTOR 0.63 9.03 0.45 1.44e-17 Body mass index; CRC cis rs7527798 0.592 rs2025372 chr1:207829653 T/G cg09232269 chr1:207846808 CR1L -0.45 -7.31 -0.37 2.02e-12 Erythrocyte sedimentation rate; CRC cis rs4662945 0.525 rs28819474 chr2:130264623 T/C cg05962382 chr2:130345044 NA -0.44 -7.73 -0.39 1.28e-13 Response to cytidine analogues (gemcitabine); CRC cis rs7677751 0.806 rs4864857 chr4:55089814 T/C cg13615338 chr4:55094005 PDGFRA 0.41 5.9 0.31 8.93e-9 Corneal astigmatism; CRC cis rs9905704 0.647 rs8077332 chr17:57105223 A/G cg12560992 chr17:57184187 TRIM37 0.65 9.95 0.48 1.4e-20 Testicular germ cell tumor; CRC cis rs34172651 0.917 rs200538 chr16:24735736 C/T cg06028605 chr16:24865363 SLC5A11 -0.39 -7.47 -0.38 7.51e-13 Intelligence (multi-trait analysis); CRC cis rs216303 0.642 rs216324 chr12:6145225 A/G cg19878637 chr12:6148451 VWF -0.64 -6.83 -0.35 4.23e-11 Low vWF levels; CRC cis rs6500602 0.647 rs4786519 chr16:4584406 C/T cg14951292 chr16:4525986 HMOX2;NMRAL1 0.57 8.57 0.43 4.07e-16 Schizophrenia; CRC cis rs883565 0.771 rs1053516 chr3:39137883 G/A cg01426195 chr3:39028469 NA -0.52 -7.98 -0.4 2.52e-14 Handedness; CRC cis rs738322 0.935 rs133014 chr22:38571087 T/G cg25457927 chr22:38595422 NA -0.35 -7.4 -0.38 1.13e-12 Cutaneous nevi; CRC cis rs3126085 0.935 rs4845733 chr1:152162568 T/C cg09127314 chr1:152161683 NA 0.48 6.02 0.31 4.66e-9 Atopic dermatitis; CRC cis rs67478160 0.634 rs2368558 chr14:104230518 A/G cg08213375 chr14:104286397 PPP1R13B 0.59 12.05 0.55 5.96e-28 Schizophrenia; CRC trans rs916888 0.610 rs199444 chr17:44818276 T/C cg22968622 chr17:43663579 NA 0.92 12.7 0.57 2.35e-30 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs2204008 0.597 rs4002591 chr12:38133841 A/G cg13010199 chr12:38710504 ALG10B 0.45 5.77 0.3 1.83e-8 Bladder cancer; CRC cis rs73058052 0.569 rs10417980 chr19:50101713 T/C cg15963326 chr19:50037085 RCN3 -0.37 -5.96 -0.31 6.58e-9 Fibrinogen levels; CRC cis rs2953174 0.507 rs2953172 chr2:241525316 C/T cg07929629 chr2:241523174 NA 0.65 9.1 0.45 8.73e-18 Bipolar disorder; CRC trans rs1814175 0.817 rs10839397 chr11:49857074 C/T cg21153622 chr11:89784906 NA -0.38 -6.2 -0.32 1.74e-9 Height; CRC trans rs2727020 0.521 rs7930855 chr11:49521660 C/T cg11707556 chr5:10655725 ANKRD33B 0.47 7.59 0.39 3.34e-13 Coronary artery disease; CRC cis rs951366 0.528 rs1172198 chr1:205662718 C/T cg07167872 chr1:205819463 PM20D1 0.72 10.33 0.49 7.45e-22 Menarche (age at onset); CRC cis rs4727027 0.866 rs7778766 chr7:148806729 A/G cg12479418 chr7:148823350 ZNF425;ZNF398 0.45 5.99 0.31 5.44e-9 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC cis rs863345 0.526 rs857723 chr1:158604000 C/T cg12129480 chr1:158549410 OR10X1 -0.3 -6.33 -0.33 7.99e-10 Pneumococcal bacteremia; CRC cis rs7312933 0.531 rs2406674 chr12:42720150 T/C cg11827402 chr12:42719852 PPHLN1;ZCRB1 -0.63 -9.23 -0.45 3.51e-18 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CRC cis rs3768617 0.811 rs4396114 chr1:183007441 C/T ch.1.3577855R chr1:183094577 LAMC1 0.6 8.88 0.44 4.51e-17 Fuchs's corneal dystrophy; CRC cis rs909002 0.849 rs6425777 chr1:32105447 G/C cg13919466 chr1:32135498 COL16A1 -0.31 -6.09 -0.32 3.2e-9 Intelligence (multi-trait analysis); CRC trans rs61931739 0.517 rs12367881 chr12:34175508 T/C cg26384229 chr12:38710491 ALG10B 0.55 7.0 0.36 1.44e-11 Morning vs. evening chronotype; CRC cis rs1348850 0.632 rs12467363 chr2:178502512 C/T cg02961200 chr2:178257176 LOC100130691;AGPS 0.62 8.77 0.44 9.58e-17 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs2404602 0.740 rs34924128 chr15:76965169 T/G cg23625390 chr15:77176239 SCAPER 0.49 7.22 0.37 3.68e-12 Blood metabolite levels; CRC cis rs1552244 1.000 rs3895942 chr3:10108745 G/C cg13047869 chr3:10149882 C3orf24 0.54 7.5 0.38 6.09e-13 Alzheimer's disease; CRC trans rs7618501 0.633 rs2526748 chr3:50080439 A/G cg21659725 chr3:3221576 CRBN -0.54 -8.5 -0.42 6.55e-16 Intelligence (multi-trait analysis); CRC cis rs10504229 1.000 rs77857677 chr8:58170131 G/A cg22535103 chr8:58192502 C8orf71 -0.82 -12.27 -0.56 9.63e-29 Developmental language disorder (linguistic errors); CRC cis rs7849270 0.959 rs10739742 chr9:131921668 A/G cg13538475 chr9:131942899 NA -0.34 -6.7 -0.35 9.2e-11 Blood metabolite ratios; CRC cis rs10193935 1.000 rs57883795 chr2:42387926 C/T cg27598129 chr2:42591480 NA -0.71 -7.07 -0.36 9.48e-12 Colonoscopy-negative controls vs population controls; CRC cis rs172166 0.694 rs536704 chr6:28092603 T/G cg21251018 chr6:28226885 NKAPL 0.46 7.07 0.36 9.6e-12 Cardiac Troponin-T levels; CRC cis rs6076065 0.748 rs999068 chr20:23376483 G/A cg11657817 chr20:23433608 CST11 0.55 9.46 0.46 6.06e-19 Facial morphology (factor 15, philtrum width); CRC cis rs7246657 0.943 rs10409204 chr19:37917692 G/A cg23950597 chr19:37808831 NA -0.53 -6.4 -0.33 5.48e-10 Coronary artery calcification; CRC cis rs6121246 0.909 rs6089058 chr20:30326338 T/G cg18721089 chr20:30220636 NA -0.36 -5.86 -0.31 1.12e-8 Mean corpuscular hemoglobin; CRC trans rs3733585 0.699 rs4408959 chr4:9948868 C/T cg26043149 chr18:55253948 FECH -0.47 -7.02 -0.36 1.26e-11 Cleft plate (environmental tobacco smoke interaction); CRC cis rs1348850 0.914 rs10194648 chr2:178337031 G/A cg02961200 chr2:178257176 LOC100130691;AGPS 0.63 9.13 0.45 7.15e-18 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs644799 0.664 rs603625 chr11:95554283 G/A cg25622487 chr11:95524042 FAM76B;CEP57 0.79 13.51 0.6 2.23e-33 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs854572 0.600 rs705382 chr7:94955221 C/G cg20119798 chr7:94954144 PON1 -0.65 -10.98 -0.52 4.2e-24 Paraoxonase activity; CRC cis rs3785574 0.925 rs2727340 chr17:61970224 T/A cg06601766 chr17:61851465 DDX42;CCDC47 0.6 8.33 0.42 2.17e-15 Height; CRC cis rs7809950 0.861 rs10264412 chr7:107183877 G/A cg23024343 chr7:107201750 COG5 -0.75 -10.2 -0.49 2.08e-21 Coronary artery disease; CRC cis rs1552244 0.572 rs6785976 chr3:10168647 A/G cg00166722 chr3:10149974 C3orf24 0.64 7.57 0.39 3.79e-13 Alzheimer's disease; CRC cis rs2976388 0.556 rs4736300 chr8:143829269 C/T cg05569086 chr8:143859399 LYNX1 -0.4 -6.3 -0.33 9.28e-10 Urinary tract infection frequency; CRC trans rs2270927 0.510 rs6453214 chr5:75584423 A/G cg13563193 chr19:33072644 PDCD5 0.7 6.2 0.32 1.66e-9 Mean corpuscular volume; CRC cis rs1670533 0.932 rs935968 chr4:1063187 G/T cg27284194 chr4:1044797 NA 0.45 5.91 0.31 8.47e-9 Recombination rate (females); CRC cis rs7772486 0.875 rs2474353 chr6:146323883 G/A cg13319975 chr6:146136371 FBXO30 -0.38 -5.67 -0.3 3.14e-8 Lobe attachment (rater-scored or self-reported); CRC cis rs73206853 0.841 rs7961345 chr12:111081598 C/T cg12870014 chr12:110450643 ANKRD13A 0.76 7.16 0.37 5.14e-12 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC cis rs7727544 0.716 rs4705926 chr5:131561758 C/T cg14196790 chr5:131705035 SLC22A5 0.36 6.22 0.32 1.48e-9 Blood metabolite levels; CRC cis rs7647973 1.000 rs2312462 chr3:49601255 A/G cg07636037 chr3:49044803 WDR6 0.67 8.27 0.41 3.3e-15 Menarche (age at onset); CRC cis rs9868809 0.649 rs17256786 chr3:48604016 C/G cg01304814 chr3:48885189 PRKAR2A 0.9 5.9 0.31 9.14e-9 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; CRC cis rs6502050 0.835 rs6502068 chr17:80112223 C/T cg11859384 chr17:80120422 CCDC57 -0.37 -5.82 -0.31 1.4e-8 Life satisfaction; CRC cis rs13108904 0.870 rs13132584 chr4:1251504 G/T cg02018176 chr4:1364513 KIAA1530 0.45 7.56 0.38 4.03e-13 Obesity-related traits; CRC cis rs6066835 0.572 rs6066804 chr20:47262322 G/A cg18078177 chr20:47281410 PREX1 0.79 6.15 0.32 2.26e-9 Multiple myeloma; CRC cis rs11608355 0.515 rs61941631 chr12:109935475 C/T cg05360138 chr12:110035743 NA 0.76 8.5 0.42 6.78e-16 Neuroticism; CRC cis rs8067545 0.611 rs11653630 chr17:20189046 C/T cg13482628 chr17:19912719 NA -0.49 -7.79 -0.39 8.79e-14 Schizophrenia; CRC cis rs6570726 0.791 rs9403730 chr6:145907233 C/T cg23711669 chr6:146136114 FBXO30 0.68 11.35 0.53 2.09e-25 Lobe attachment (rater-scored or self-reported); CRC cis rs802075 0.967 rs360562 chr6:49658441 G/T cg20364632 chr6:49636226 NA -0.37 -5.97 -0.31 6.3e-9 Bone mineral density (hip) and age at menarche; CRC trans rs6703335 0.870 rs10803142 chr1:243598234 A/G cg14094063 chr7:140624470 BRAF 0.43 6.23 0.32 1.46e-9 Schizophrenia;Schizophrenia, schizoaffective disorder or bipolar disorder; CRC cis rs17152411 0.895 rs11245419 chr10:126586392 A/T cg07906193 chr10:126599966 NA 0.56 6.33 0.33 7.97e-10 Height; CRC cis rs12908161 0.959 rs1051168 chr15:85200520 G/T cg17507749 chr15:85114479 UBE2QP1 0.62 8.58 0.43 3.89e-16 Schizophrenia; CRC cis rs1008375 0.800 rs10008598 chr4:17607323 T/C cg16339924 chr4:17578868 LAP3 0.5 6.58 0.34 1.87e-10 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs2386661 0.522 rs11258033 chr10:5644372 C/T cg26603656 chr10:5671107 NA -0.36 -6.25 -0.33 1.25e-9 Breast cancer; CRC cis rs6502050 0.835 rs9674648 chr17:80096756 A/G cg13198984 chr17:80129470 CCDC57 0.46 8.24 0.41 4.06e-15 Life satisfaction; CRC trans rs875971 0.660 rs2191268 chr7:66110224 C/T cg22090150 chr17:4098227 ANKFY1 0.4 6.46 0.34 3.84e-10 Aortic root size; CRC cis rs13118159 0.778 rs12640984 chr4:1338834 G/A cg16405210 chr4:1374714 KIAA1530 -0.41 -5.83 -0.31 1.31e-8 Longevity; CRC cis rs9487051 0.652 rs13210424 chr6:109598737 G/A cg01475377 chr6:109611718 NA -0.37 -6.55 -0.34 2.18e-10 Reticulocyte fraction of red cells; CRC trans rs684232 0.644 rs2543781 chr17:602469 C/G cg22807402 chr17:73269154 SLC25A19 -0.34 -6.0 -0.31 5.23e-9 Prostate cancer; CRC cis rs270601 0.690 rs162904 chr5:131595784 C/T cg09877947 chr5:131593287 PDLIM4 -0.52 -8.94 -0.44 2.87e-17 Acylcarnitine levels; CRC cis rs514406 0.861 rs11206026 chr1:53281708 G/A cg24675658 chr1:53192096 ZYG11B -0.57 -8.28 -0.42 3.06e-15 Monocyte count; CRC cis rs12477438 0.798 rs6704766 chr2:99642818 T/C cg26064155 chr2:99771622 LIPT1;TSGA10 -0.79 -11.26 -0.53 4.29e-25 Chronic sinus infection; CRC cis rs7246657 0.943 rs10417844 chr19:37837587 C/T cg23950597 chr19:37808831 NA -0.47 -5.76 -0.3 1.94e-8 Coronary artery calcification; CRC cis rs3741151 0.773 rs74881062 chr11:73245769 G/A cg17517138 chr11:73019481 ARHGEF17 0.95 7.78 0.39 9.74e-14 GIP levels in response to oral glucose tolerance test (120 minutes); CRC trans rs9929218 0.551 rs2274239 chr16:68725783 G/A cg04657470 chr2:198365150 HSPE1;HSPD1 1.13 26.14 0.82 2.79e-82 Colorectal cancer; CRC cis rs9372498 0.536 rs9489428 chr6:118852935 T/C cg24463073 chr6:118973353 C6orf204 0.52 6.97 0.36 1.69e-11 Diastolic blood pressure; CRC cis rs490234 0.812 rs17259739 chr9:128456639 C/T cg14078157 chr9:128172775 NA 0.36 5.69 0.3 2.86e-8 Mean arterial pressure; CRC cis rs936229 0.871 rs2290574 chr15:75135447 T/C cg14664628 chr15:75095509 CSK -0.97 -17.82 -0.7 3.28e-50 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); CRC cis rs910316 0.967 rs35446981 chr14:75637351 A/T cg03030879 chr14:75389066 RPS6KL1 0.44 6.67 0.35 1.08e-10 Height; CRC cis rs28374715 0.578 rs72739630 chr15:41631064 G/A cg18705301 chr15:41695430 NDUFAF1 -1.12 -18.2 -0.71 1.05e-51 Ulcerative colitis; CRC cis rs763014 0.966 rs15564 chr16:677854 G/T cg09263875 chr16:632152 PIGQ 0.78 12.84 0.58 7.15e-31 Height; CRC trans rs4853036 0.672 rs34764641 chr2:70024823 G/T cg14633329 chr9:139640053 LCN6 -0.34 -6.02 -0.31 4.72e-9 Colorectal or endometrial cancer; CRC cis rs1165668 0.785 rs2070908 chr12:104324182 C/G cg21863207 chr12:104234989 NT5DC3 -0.5 -7.58 -0.39 3.53e-13 Coronary heart disease (SNP X SNP interaction); CRC cis rs172166 0.637 rs1225595 chr6:28151340 A/T cg25164649 chr6:28176230 NA 0.69 10.25 0.49 1.39e-21 Cardiac Troponin-T levels; CRC cis rs3008870 0.958 rs12131222 chr1:67438535 A/T cg08660285 chr1:67390436 MIER1;WDR78 -1.04 -15.24 -0.64 4.66e-40 Lymphocyte percentage of white cells; CRC cis rs9399135 0.967 rs4451151 chr6:135310546 C/T cg22676075 chr6:135203613 NA 0.43 6.73 0.35 7.43e-11 Red blood cell count; CRC cis rs2576037 0.526 rs658756 chr18:44431832 A/G cg19077165 chr18:44547161 KATNAL2 -0.56 -9.44 -0.46 7.34e-19 Personality dimensions; CRC cis rs7927771 0.507 rs7111606 chr11:47787538 G/A cg20307385 chr11:47447363 PSMC3 0.45 6.57 0.34 1.92e-10 Subjective well-being; CRC cis rs769267 1.000 rs8103197 chr19:19443466 C/T cg20644253 chr19:19431407 KIAA0892;SF4 -0.41 -5.69 -0.3 2.78e-8 Tonsillectomy; CRC cis rs4665809 0.877 rs35224700 chr2:26298037 T/C cg26119090 chr2:26468346 HADHA;HADHB 0.64 7.35 0.38 1.6e-12 Gut microbiome composition (summer); CRC cis rs1949733 1.000 rs2631745 chr4:8490530 T/C cg13073564 chr4:8508604 NA 0.5 7.7 0.39 1.5700000000000001e-13 Response to antineoplastic agents; CRC cis rs9457247 0.765 rs9457252 chr6:167433925 A/G cg07741184 chr6:167504864 NA -0.38 -6.6 -0.34 1.67e-10 Crohn's disease; CRC trans rs4332037 0.624 rs11764337 chr7:1892309 A/G cg11693508 chr17:37793320 STARD3 -0.64 -8.43 -0.42 1.08e-15 Bipolar disorder; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg05877740 chr15:64673601 KIAA0101 0.43 6.15 0.32 2.31e-9 Intelligence (multi-trait analysis); CRC cis rs1552244 0.872 rs6792951 chr3:10119603 C/A cg16606324 chr3:10149918 C3orf24 0.7 9.72 0.47 8.71e-20 Alzheimer's disease; CRC trans rs1459104 0.571 rs10459012 chr11:55091574 C/A cg15704280 chr7:45808275 SEPT13 0.56 6.63 0.34 1.38e-10 Body mass index; CRC cis rs1153858 1.000 rs4395020 chr15:45652889 A/C cg10760299 chr15:45669010 GATM 0.5 7.99 0.4 2.28e-14 Homoarginine levels; CRC cis rs11098499 0.743 rs11098501 chr4:120252017 T/G cg09307838 chr4:120376055 NA 0.61 9.59 0.47 2.22e-19 Corneal astigmatism; CRC cis rs9768139 0.903 rs28503558 chr7:158119568 C/T cg06219351 chr7:158114137 PTPRN2 0.43 6.56 0.34 2.12e-10 Calcium levels; CRC cis rs1728785 1.000 rs1749791 chr16:68572347 C/T cg02972257 chr16:68554789 NA -0.58 -7.15 -0.37 5.78e-12 Ulcerative colitis; CRC cis rs780096 0.546 rs4665976 chr2:27640325 A/G cg12648201 chr2:27665141 KRTCAP3 -0.29 -5.84 -0.31 1.23e-8 Total body bone mineral density; CRC cis rs4144743 1.000 rs10438781 chr17:45323819 A/G cg18085866 chr17:45331354 ITGB3 -0.59 -8.11 -0.41 1.02e-14 Body mass index; CRC cis rs7666738 0.753 rs10029372 chr4:98859002 T/C cg05340658 chr4:99064831 C4orf37 0.57 8.45 0.42 9.23e-16 Colonoscopy-negative controls vs population controls; CRC cis rs875971 1.000 rs1540651 chr7:65650121 C/T cg11764359 chr7:65958608 NA -0.62 -9.99 -0.48 1.04e-20 Aortic root size; CRC trans rs3733585 0.673 rs4455410 chr4:9953297 C/T cg26043149 chr18:55253948 FECH 0.49 7.37 0.38 1.35e-12 Cleft plate (environmental tobacco smoke interaction); CRC cis rs9811920 0.809 rs4928150 chr3:99685991 A/C cg07805332 chr3:99536008 MIR548G;C3orf26 -0.37 -5.73 -0.3 2.22e-8 Axial length; CRC cis rs6840360 0.615 rs72728179 chr4:152477877 A/G cg09659197 chr4:152720779 NA 0.31 5.64 0.3 3.6e-8 Intelligence (multi-trait analysis); CRC cis rs1552244 0.882 rs56332224 chr3:10037321 G/A cg13047869 chr3:10149882 C3orf24 0.52 7.1 0.36 7.53e-12 Alzheimer's disease; CRC cis rs2731664 0.792 rs335420 chr5:176898619 C/T cg23176889 chr5:176863531 GRK6 0.73 16.05 0.66 3.26e-43 Intelligence (multi-trait analysis); CRC cis rs13064411 0.696 rs6766615 chr3:113219342 T/C cg18753928 chr3:113234510 CCDC52 -0.69 -10.86 -0.51 1.08e-23 Response to simvastatin treatment (PCSK9 protein level change); CRC cis rs17253792 0.915 rs78089630 chr14:56178584 G/C cg01858014 chr14:56050164 KTN1 -0.79 -6.09 -0.32 3.09e-9 Putamen volume; CRC cis rs921968 0.541 rs6720403 chr2:219294258 A/C cg02176678 chr2:219576539 TTLL4 -0.55 -8.68 -0.43 1.81e-16 Mean corpuscular hemoglobin concentration; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg08226295 chr22:31892562 SFI1 0.39 6.47 0.34 3.57e-10 Liver disease severity in Alagille syndrome; CRC cis rs2072499 0.778 rs2247476 chr1:156190280 C/A cg25208724 chr1:156163844 SLC25A44 0.96 14.96 0.64 5.92e-39 Testicular germ cell tumor; CRC cis rs28386778 0.865 rs2727276 chr17:61929709 G/A cg22520471 chr17:61851767 DDX42;CCDC47 0.73 11.34 0.53 2.15e-25 Prudent dietary pattern; CRC cis rs73200209 0.744 rs61937387 chr12:116707971 A/T cg01776926 chr12:116560359 MED13L -0.62 -7.31 -0.37 2.11e-12 Total body bone mineral density; CRC cis rs3806843 0.750 rs2563285 chr5:140126137 T/C cg16607685 chr5:140181889 PCDHA2;PCDHA1;PCDHA3 0.27 6.28 0.33 1.1e-9 Depressive symptoms (multi-trait analysis); CRC cis rs561341 1.000 rs542132 chr17:30307193 A/T cg23018236 chr17:30244563 NA -0.67 -8.03 -0.4 1.72e-14 Hip circumference adjusted for BMI; CRC cis rs1552244 0.572 rs58862481 chr3:10164308 G/A cg16606324 chr3:10149918 C3orf24 0.69 8.08 0.41 1.2e-14 Alzheimer's disease; CRC cis rs17826219 0.706 rs8075107 chr17:29106649 C/A cg13385521 chr17:29058706 SUZ12P 0.73 8.4 0.42 1.39e-15 Body mass index; CRC cis rs7258465 1.000 rs34746918 chr19:18539744 C/T cg10790698 chr19:18539756 SSBP4 -0.47 -8.7 -0.43 1.6e-16 Breast cancer; CRC cis rs775227 0.574 rs16860849 chr3:113049993 C/T cg18753928 chr3:113234510 CCDC52 0.54 6.71 0.35 8.48e-11 Dental caries; CRC trans rs6545883 0.929 rs7561229 chr2:61737990 A/T cg11704114 chr12:21509398 SLCO1A2 -0.33 -6.22 -0.32 1.52e-9 Tuberculosis; CRC trans rs113835537 0.627 rs4630309 chr11:66333072 A/C cg26761047 chr1:15944228 DDI2 0.6 6.38 0.33 5.91e-10 Airway imaging phenotypes; CRC cis rs9372498 0.536 rs9320656 chr6:118894468 A/G cg07617317 chr6:118971624 C6orf204 -0.49 -6.16 -0.32 2.08e-9 Diastolic blood pressure; CRC cis rs798554 0.679 rs2533870 chr7:2885274 C/G cg19717773 chr7:2847554 GNA12 0.42 5.91 0.31 8.67e-9 Height; CRC cis rs7917772 0.503 rs7914389 chr10:104295402 T/C cg04362960 chr10:104952993 NT5C2 -0.41 -5.79 -0.3 1.62e-8 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC cis rs6840360 0.617 rs2724563 chr4:152349959 G/C cg09659197 chr4:152720779 NA 0.34 6.66 0.34 1.14e-10 Intelligence (multi-trait analysis); CRC cis rs739401 0.611 rs2071104 chr11:3036933 G/T cg05729581 chr11:3078854 CARS -0.59 -8.87 -0.44 4.75e-17 Longevity; CRC trans rs7937682 0.889 rs1789361 chr11:111485334 T/C cg18187862 chr3:45730750 SACM1L 0.47 6.78 0.35 5.68e-11 Primary sclerosing cholangitis; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg15974272 chr11:2466598 KCNQ1 0.44 6.03 0.32 4.35e-9 Anxiety disorder; CRC cis rs4728302 1.000 rs4728302 chr7:133630463 C/T cg10665199 chr7:133106180 EXOC4 -0.39 -6.1 -0.32 2.9e-9 Intelligence;Intelligence (multi-trait analysis); CRC cis rs9583531 0.527 rs2391866 chr13:111363294 A/T cg24331049 chr13:111365604 ING1 0.57 7.82 0.4 7.12e-14 Coronary artery disease; CRC cis rs910316 0.789 rs175457 chr14:75584507 C/T cg11812906 chr14:75593930 NEK9 -0.54 -8.31 -0.42 2.53e-15 Height; CRC cis rs13082711 0.911 rs34878935 chr3:27466123 A/C cg02860705 chr3:27208620 NA 0.62 8.76 0.43 1.04e-16 Systolic blood pressure;Diastolic blood pressure;Blood pressure; CRC cis rs10504229 0.683 rs59528137 chr8:58138565 C/T cg02725872 chr8:58115012 NA -0.58 -8.11 -0.41 1.03e-14 Developmental language disorder (linguistic errors); CRC cis rs12048904 0.505 rs6577209 chr1:101255080 A/C cg15686842 chr1:101360669 SLC30A7;EXTL2 0.5 6.74 0.35 7.06e-11 Multiple sclerosis; CRC trans rs7618501 0.933 rs3811695 chr3:49761613 C/T cg21582582 chr3:182698605 DCUN1D1 -0.54 -7.93 -0.4 3.37e-14 Intelligence (multi-trait analysis); CRC cis rs864537 0.584 rs7523907 chr1:167427247 A/G cg09179987 chr1:167433047 CD247 0.44 6.94 0.36 2.07e-11 Celiac disease or Rheumatoid arthritis;Celiac disease; CRC cis rs208520 0.507 rs3903670 chr6:66812183 T/C cg07460842 chr6:66804631 NA -1.2 -25.61 -0.82 2.42e-80 Exhaled nitric oxide output; CRC cis rs9467773 0.620 rs2504592 chr6:26640951 C/G cg09904177 chr6:26538194 HMGN4 0.72 11.32 0.53 2.68e-25 Intelligence (multi-trait analysis); CRC cis rs1153858 1.000 rs4775937 chr15:45678614 C/A cg10760299 chr15:45669010 GATM 0.5 7.73 0.39 1.29e-13 Homoarginine levels; CRC cis rs4731207 0.564 rs7794565 chr7:124648968 A/C cg23710748 chr7:124431027 NA -0.39 -6.25 -0.33 1.24e-9 Cutaneous malignant melanoma; CRC cis rs375066 0.623 rs7247863 chr19:44354518 A/G cg19542119 chr19:44331823 ZNF283 0.4 5.61 0.3 4.24e-8 Breast cancer; CRC cis rs364477 0.904 rs382037 chr9:957521 G/C cg13952963 chr9:998547 NA 0.54 5.85 0.31 1.21e-8 Major depressive disorder; CRC cis rs6867032 1.000 rs4413568 chr5:2016894 A/G cg26168224 chr5:2018326 NA 1.1 24.03 0.8 2.18e-74 Gut microbiome composition (winter); CRC cis rs2404602 0.583 rs2469542 chr15:76557476 A/G cg26408565 chr15:76604113 ETFA 0.37 5.85 0.31 1.2e-8 Blood metabolite levels; CRC cis rs514406 0.505 rs269293 chr1:53187767 A/C cg24675658 chr1:53192096 ZYG11B -0.67 -10.16 -0.49 2.85e-21 Monocyte count; CRC cis rs7534824 0.625 rs7545402 chr1:101321076 C/T cg16556008 chr1:101360663 SLC30A7;EXTL2 0.58 5.61 0.3 4.27e-8 Refractive astigmatism; CRC cis rs1882538 0.506 rs7805858 chr7:133126589 G/T cg10665199 chr7:133106180 EXOC4 0.57 8.62 0.43 2.87e-16 Intelligence (multi-trait analysis); CRC cis rs1552244 1.000 rs12152515 chr3:10143976 C/T cg18598329 chr3:10140678 FANCD2;C3orf24 -0.88 -12.91 -0.58 3.94e-31 Alzheimer's disease; CRC trans rs7618501 0.633 rs7621026 chr3:49975334 A/G cg21659725 chr3:3221576 CRBN 0.54 8.45 0.42 9.28e-16 Intelligence (multi-trait analysis); CRC cis rs12995491 0.731 rs17435439 chr2:88511391 A/G cg07952391 chr2:88470173 THNSL2 -0.41 -6.03 -0.32 4.44e-9 Response to metformin (IC50); CRC cis rs7677751 0.767 rs6846502 chr4:55062090 T/C cg00691999 chr4:55094011 PDGFRA 0.41 5.73 0.3 2.31e-8 Corneal astigmatism; CRC cis rs6860806 0.507 rs156322 chr5:131653925 C/T cg02033258 chr5:131593261 PDLIM4 0.36 5.88 0.31 1.03e-8 Breast cancer; CRC cis rs9811920 0.732 rs7613864 chr3:99602470 T/C cg07805332 chr3:99536008 MIR548G;C3orf26 -0.39 -6.08 -0.32 3.35e-9 Axial length; CRC cis rs17401966 0.558 rs12128374 chr1:10426417 G/A cg19773385 chr1:10388646 KIF1B -0.47 -7.47 -0.38 7.07e-13 Hepatocellular carcinoma; CRC cis rs362272 0.505 rs10155132 chr4:3369500 A/G cg01612440 chr4:3296283 NA 0.41 5.93 0.31 7.57e-9 Serum sulfate level; CRC cis rs9534288 0.699 rs9567621 chr13:46665814 A/G cg15192986 chr13:46630673 CPB2 -0.6 -8.28 -0.42 3.12e-15 Blood protein levels; CRC cis rs1150668 0.796 rs9468372 chr6:28379361 T/A cg15845792 chr6:28175446 NA 0.48 6.99 0.36 1.56e-11 Pubertal anthropometrics; CRC cis rs4076764 0.958 rs6688181 chr1:163384193 C/T cg24596788 chr1:163392923 NA 0.62 9.93 0.48 1.66e-20 Motion sickness; CRC cis rs34779708 0.733 rs7914468 chr10:35548071 G/A cg03585969 chr10:35415529 CREM 0.52 6.79 0.35 5.37e-11 Inflammatory bowel disease;Crohn's disease; CRC cis rs6951245 0.935 rs61910751 chr7:1097895 A/G cg26224354 chr7:1096374 C7orf50;GPR146 -0.93 -12.05 -0.55 5.9e-28 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs9435341 0.965 rs1730862 chr1:107614003 G/A cg14828511 chr1:107599125 PRMT6 -0.54 -7.45 -0.38 8.11e-13 Facial morphology (factor 21, depth of nasal alae); CRC cis rs12701220 0.894 rs34712249 chr7:1036634 C/T cg02733842 chr7:1102375 C7orf50 -0.84 -10.25 -0.49 1.39e-21 Bronchopulmonary dysplasia; CRC cis rs116095464 0.558 rs62344345 chr5:257420 C/T cg22496380 chr5:211416 CCDC127 -0.91 -10.45 -0.5 2.88e-22 Breast cancer; CRC cis rs3785574 0.962 rs13030 chr17:61908556 C/T cg23090583 chr17:61904693 PSMC5;FTSJ3 0.65 9.26 0.45 2.71e-18 Height; CRC cis rs2274273 0.624 rs8014477 chr14:55841477 A/G cg10130446 chr14:55658398 DLGAP5 0.42 6.09 0.32 3.14e-9 Protein biomarker; CRC cis rs9329289 0.926 rs10903784 chr10:2541943 G/T cg15501526 chr10:2543763 NA -0.76 -15.86 -0.66 1.84e-42 Age-related hearing impairment; CRC cis rs727505 1.000 rs56313563 chr7:124507003 G/A cg23710748 chr7:124431027 NA -0.8 -14.18 -0.62 6.24e-36 Lewy body disease; CRC cis rs6951245 0.935 rs76525951 chr7:1096013 C/T cg03188948 chr7:1209495 NA 0.66 6.94 0.36 2.04e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs13191362 1.000 rs67646369 chr6:163003233 T/C cg23758597 chr6:163146217 PARK2 -0.55 -6.12 -0.32 2.61e-9 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs12048904 0.533 rs1590580 chr1:101292668 A/G cg15686842 chr1:101360669 SLC30A7;EXTL2 0.54 6.94 0.36 2.06e-11 Multiple sclerosis; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg20623943 chr1:47799834 CMPK1 0.42 6.01 0.31 4.81e-9 Intelligence (multi-trait analysis); CRC cis rs897984 0.806 rs1458202 chr16:30953202 A/G cg00531865 chr16:30841666 NA -0.5 -7.15 -0.37 5.68e-12 Dementia with Lewy bodies; CRC cis rs2749592 0.531 rs10764134 chr10:37856660 T/C cg25427524 chr10:38739819 LOC399744 0.67 11.1 0.52 1.53e-24 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs12230513 0.732 rs61956327 chr12:55828708 C/T cg19537932 chr12:55886519 OR6C68 -0.75 -9.64 -0.47 1.53e-19 Contrast sensitivity; CRC cis rs2839186 0.559 rs2277826 chr21:47639492 C/G cg26721908 chr21:47610096 LSS 0.4 6.03 0.32 4.3e-9 Testicular germ cell tumor; CRC cis rs992157 0.798 rs10206064 chr2:219157959 T/C cg13835894 chr2:219148914 PNKD;TMBIM1 0.33 6.31 0.33 8.82e-10 Colorectal cancer; CRC cis rs7772486 0.790 rs6917482 chr6:146243581 C/T cg13319975 chr6:146136371 FBXO30 0.41 6.15 0.32 2.25e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs62244186 0.711 rs6778410 chr3:44743993 C/T cg11003573 chr3:44754125 ZNF502 -0.37 -6.39 -0.33 5.6e-10 Depressive symptoms; CRC cis rs7811142 1.000 rs73405353 chr7:100091215 G/A cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.72 9.46 0.46 6.3e-19 Platelet count; CRC cis rs7666738 0.680 rs34267968 chr4:99002574 A/T cg05340658 chr4:99064831 C4orf37 0.61 9.54 0.47 3.44e-19 Colonoscopy-negative controls vs population controls; CRC cis rs561341 0.883 rs1034627 chr17:30219569 C/T cg00745463 chr17:30367425 LRRC37B -0.55 -6.57 -0.34 1.98e-10 Hip circumference adjusted for BMI; CRC cis rs9372498 0.536 rs72969531 chr6:118729974 C/A cg22561889 chr6:118971681 C6orf204 0.53 6.92 0.36 2.43e-11 Diastolic blood pressure; CRC cis rs921968 0.613 rs1427445 chr2:219555573 C/A cg02176678 chr2:219576539 TTLL4 -0.46 -7.28 -0.37 2.47e-12 Mean corpuscular hemoglobin concentration; CRC cis rs4713118 0.662 rs149961 chr6:28015569 A/C cg02683197 chr6:28174875 NA 0.73 9.71 0.47 9.11e-20 Parkinson's disease; CRC cis rs17376456 0.825 rs10075217 chr5:93176774 C/G cg09848695 chr5:92956644 FAM172A;MIR2277 0.68 6.32 0.33 8.34e-10 Diabetic retinopathy; CRC cis rs4547160 0.821 rs7955356 chr12:63485687 A/G cg26727693 chr12:63544175 AVPR1A -0.41 -7.69 -0.39 1.73e-13 Morning vs. evening chronotype; CRC cis rs2153535 0.580 rs9406159 chr6:8464859 C/G cg07606381 chr6:8435919 SLC35B3 0.66 10.62 0.51 7.3e-23 Motion sickness; CRC cis rs6662572 0.737 rs4557909 chr1:46316949 T/C cg03123370 chr1:45965343 CCDC163P;MMACHC -0.46 -5.9 -0.31 8.93e-9 Blood protein levels; CRC cis rs1707322 1.000 rs1768801 chr1:46549137 C/G cg03146154 chr1:46216737 IPP -0.52 -7.18 -0.37 4.54e-12 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC trans rs10983614 1.000 rs7867776 chr9:120072627 A/G cg01074347 chr1:93427451 FAM69A 0.44 6.03 0.32 4.51e-9 Survival in pancreatic cancer; CRC trans rs2303319 0.504 rs12474470 chr2:162535336 T/C cg03757145 chr4:76555832 CDKL2 -0.66 -5.97 -0.31 5.99e-9 Cognitive function; CRC cis rs2932538 0.922 rs6690169 chr1:113114974 A/G cg22162597 chr1:113214053 CAPZA1 0.71 10.25 0.49 1.43e-21 Systolic blood pressure;Diastolic blood pressure;Hypertension;Blood pressure; CRC cis rs8072100 0.905 rs8077106 chr17:45653291 T/G cg25173405 chr17:45401733 C17orf57 0.46 7.23 0.37 3.49e-12 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs9311474 0.652 rs614288 chr3:52220203 T/C cg08222913 chr3:52553049 STAB1 -0.31 -5.93 -0.31 7.54e-9 Electroencephalogram traits; CRC cis rs11212617 0.840 rs172894 chr11:108262090 C/A cg01991180 chr11:108092276 ATM;NPAT 0.41 5.97 0.31 6.31e-9 Response to metformin in type 2 diabetes (glycemic); CRC cis rs7618915 0.531 rs77146033 chr3:52701501 G/T cg08222913 chr3:52553049 STAB1 -0.35 -6.4 -0.33 5.43e-10 Bipolar disorder; CRC cis rs7647973 0.961 rs11130187 chr3:49307872 T/C cg07636037 chr3:49044803 WDR6 0.61 7.52 0.38 5.28e-13 Menarche (age at onset); CRC cis rs3617 0.625 rs2071042 chr3:52864584 A/G cg18099408 chr3:52552593 STAB1 -0.35 -6.1 -0.32 2.91e-9 Red blood cell count;Autism spectrum disorder or schizophrenia; CRC cis rs17209837 0.607 rs2888611 chr7:87103670 C/G cg00919237 chr7:87102261 ABCB4 0.54 7.19 0.37 4.4e-12 Gallbladder cancer; CRC cis rs17376456 0.569 rs10476520 chr5:93058290 A/C cg21475434 chr5:93447410 FAM172A 0.49 5.9 0.31 8.91e-9 Diabetic retinopathy; CRC cis rs7726839 0.574 rs72705014 chr5:619815 C/G cg09021430 chr5:549028 NA -0.73 -8.35 -0.42 1.94e-15 Obesity-related traits; CRC cis rs2479724 0.875 rs2253961 chr6:41827011 A/G cg17623882 chr6:41773611 USP49 -0.52 -8.63 -0.43 2.67e-16 Menarche (age at onset); CRC cis rs11971779 0.941 rs1127424 chr7:139107660 A/G cg07862535 chr7:139043722 LUC7L2 1.05 12.63 0.57 4.57e-30 Diisocyanate-induced asthma; CRC cis rs6484504 0.576 rs2756191 chr11:31135882 A/T cg14844989 chr11:31128820 NA 0.33 5.77 0.3 1.87e-8 Red blood cell count; CRC cis rs8031584 1.000 rs1474380 chr15:31269235 T/C cg14829155 chr15:31115871 NA -0.49 -8.13 -0.41 8.67e-15 Huntington's disease progression; CRC cis rs6741819 0.911 rs11898648 chr2:7136926 C/A cg27144453 chr2:7172511 RNF144A -0.41 -5.99 -0.31 5.49e-9 Response to antipsychotic treatment; CRC cis rs9486719 0.857 rs11751075 chr6:97065751 G/A cg18709589 chr6:96969512 KIAA0776 -0.49 -6.13 -0.32 2.55e-9 Migraine;Coronary artery disease; CRC cis rs10504229 0.769 rs17215649 chr8:58152791 A/G cg08219700 chr8:58056026 NA 0.45 5.74 0.3 2.11e-8 Developmental language disorder (linguistic errors); CRC trans rs2797160 1.000 rs4895798 chr6:126000162 A/G cg05039488 chr6:79577232 IRAK1BP1 -0.5 -7.55 -0.38 4.4e-13 Endometrial cancer; CRC cis rs2976388 0.533 rs12543368 chr8:143819450 T/C cg12516270 chr8:143859308 LYNX1 -0.4 -6.22 -0.32 1.54e-9 Urinary tract infection frequency; CRC cis rs7618915 0.571 rs1961959 chr3:52585760 G/C cg15147215 chr3:52552868 STAB1 -0.63 -10.62 -0.51 7.64e-23 Bipolar disorder; CRC trans rs6601327 0.641 rs6601350 chr8:9573956 C/G cg16141378 chr3:129829833 LOC729375 0.42 6.04 0.32 4.25e-9 Multiple myeloma (hyperdiploidy); CRC cis rs6088580 0.634 rs1205345 chr20:32914699 A/G cg08999081 chr20:33150536 PIGU -0.62 -11.41 -0.53 1.24e-25 Glomerular filtration rate (creatinine); CRC cis rs6674176 0.660 rs11210936 chr1:44391438 A/T cg15962314 chr1:44399869 ARTN 0.31 6.11 0.32 2.83e-9 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Cognitive ability; CRC cis rs7213347 0.707 rs2038677 chr17:2178092 C/G cg15816464 chr17:2026533 SMG6 0.37 6.16 0.32 2.12e-9 Total body bone mineral density; CRC cis rs875971 1.000 rs875971 chr7:65617595 A/G cg18876405 chr7:65276391 NA -0.5 -8.67 -0.43 1.99e-16 Aortic root size; CRC cis rs13315871 0.929 rs13075746 chr3:58293867 G/A cg20936604 chr3:58311152 NA -0.74 -6.94 -0.36 2.05e-11 Cholesterol, total; CRC cis rs3091242 0.967 rs665372 chr1:25719235 A/C cg20684491 chr1:25596433 NA 0.43 7.48 0.38 6.65e-13 Erythrocyte sedimentation rate; CRC trans rs12495832 0.749 rs79597840 chr3:147926901 C/T cg10221266 chr7:153579447 NA 0.57 6.37 0.33 6.44e-10 Chin dimples; CRC trans rs561341 0.883 rs2074102 chr17:30228884 G/A cg20587970 chr11:113659929 NA -1.03 -12.4 -0.56 3.16e-29 Hip circumference adjusted for BMI; CRC cis rs2075371 0.933 rs432336 chr7:133949064 A/G cg20476274 chr7:133979776 SLC35B4 0.78 14.14 0.61 8.77e-36 Mean platelet volume; CRC cis rs9487051 0.698 rs35757653 chr6:109644599 A/C cg01475377 chr6:109611718 NA -0.38 -5.79 -0.3 1.61e-8 Reticulocyte fraction of red cells; CRC cis rs477895 0.838 rs1058735 chr11:64000410 C/G cg19465662 chr11:63993652 NUDT22;TRPT1 0.76 9.27 0.45 2.57e-18 Mean platelet volume; CRC trans rs8005745 0.505 rs710047 chr14:62118819 C/G cg19223106 chr19:58898630 RPS5 -0.45 -6.32 -0.33 8.56e-10 Select biomarker traits; CRC cis rs10256972 0.621 rs2363285 chr7:1091644 C/T cg22907277 chr7:1156413 C7orf50 0.38 5.7 0.3 2.62e-8 Longevity;Endometriosis; CRC cis rs883565 0.569 rs784514 chr3:39164622 A/G cg01426195 chr3:39028469 NA 0.42 6.99 0.36 1.56e-11 Handedness; CRC cis rs34172651 0.517 rs189919 chr16:24737741 G/A cg02428538 chr16:24856791 SLC5A11 0.62 7.16 0.37 5.24e-12 Intelligence (multi-trait analysis); CRC cis rs4819052 1.000 rs2838830 chr21:46664227 T/G cg19498844 chr21:46707878 POFUT2;LOC642852 0.85 11.38 0.53 1.62e-25 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC trans rs314253 1.000 rs314253 chr17:7091650 A/G cg23681664 chr3:9746637 CPNE9 -0.31 -5.99 -0.31 5.61e-9 LDL cholesterol levels;Cholesterol, total;LDL cholesterol;Liver enzyme levels (alkaline phosphatase); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg06382698 chr2:54015232 LOC100302652;ERLEC1;ASB3 0.43 6.06 0.32 3.81e-9 Response to antipsychotic treatment; CRC cis rs9463078 0.587 rs1150806 chr6:44897787 C/T cg25276700 chr6:44698697 NA -0.25 -6.06 -0.32 3.75e-9 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; CRC trans rs10983614 1.000 rs7867776 chr9:120072627 A/G cg07754938 chr3:48885314 PRKAR2A 0.45 6.18 0.32 1.92e-9 Survival in pancreatic cancer; CRC cis rs6088813 1.000 rs6142370 chr20:33973378 G/A cg14752227 chr20:34000481 UQCC -0.36 -5.62 -0.3 3.99e-8 Height; CRC cis rs4713118 0.662 rs9468274 chr6:28026077 G/T cg12172441 chr6:28176163 NA 0.55 6.96 0.36 1.83e-11 Parkinson's disease; CRC cis rs1005277 0.579 rs2472175 chr10:38382901 T/G cg00409905 chr10:38381863 ZNF37A -0.68 -11.31 -0.53 2.89e-25 Extrinsic epigenetic age acceleration; CRC cis rs875971 0.862 rs7783779 chr7:65796626 A/G cg12463550 chr7:65579703 CRCP -0.5 -6.75 -0.35 6.65e-11 Aortic root size; CRC cis rs7914558 1.000 rs1890184 chr10:104748459 A/C cg15744005 chr10:104629667 AS3MT -0.34 -7.23 -0.37 3.38e-12 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs2457480 0.543 rs1905150 chr10:44713311 G/A cg09554077 chr10:44749378 NA 0.51 6.75 0.35 6.54e-11 Coronary artery disease; CRC cis rs9326248 0.727 rs4938347 chr11:117021759 T/A cg26566898 chr11:117069891 TAGLN 0.38 6.88 0.35 2.96e-11 Blood protein levels; CRC cis rs6764363 0.527 rs7648248 chr3:275692 A/G cg02057681 chr3:285234 CHL1 0.4 6.68 0.35 1.01e-10 Sudden cardiac arrest; CRC cis rs4819052 0.819 rs34818688 chr21:46672416 C/T cg11663144 chr21:46675770 NA -0.85 -15.03 -0.64 3.12e-39 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC trans rs61931739 0.500 rs7137392 chr12:34447074 T/C cg13010199 chr12:38710504 ALG10B 0.46 6.52 0.34 2.6200000000000003e-10 Morning vs. evening chronotype; CRC trans rs587242 1.000 rs12744194 chr1:96898486 T/G cg10631902 chr5:14652156 NA 0.44 6.84 0.35 3.84e-11 Body mass index (joint analysis main effects and physical activity interaction);Body mass index in physically inactive individuals;Body mass index; CRC trans rs3749237 1.000 rs11717256 chr3:49868520 C/T cg21665057 chr3:196295764 WDR53;FBXO45 0.55 7.9 0.4 4.14e-14 Resting heart rate; CRC cis rs2108225 1.000 rs2108226 chr7:107453279 A/C cg18560240 chr7:107437656 SLC26A3 -0.6 -9.43 -0.46 7.76e-19 Ulcerative colitis; CRC cis rs2228479 0.850 rs62054601 chr16:89811751 C/G cg06656553 chr16:89960601 TCF25 -0.69 -5.74 -0.3 2.15e-8 Skin colour saturation; CRC cis rs7618915 0.547 rs6762813 chr3:52726695 C/T cg15147215 chr3:52552868 STAB1 -0.63 -10.38 -0.5 4.99e-22 Bipolar disorder; CRC cis rs10971721 1.000 rs10971721 chr9:33827694 C/T cg13495928 chr9:33750294 PRSS3 0.55 5.86 0.31 1.14e-8 Body mass index; CRC cis rs7618501 1.000 rs4855862 chr3:49748833 C/T cg24308560 chr3:49941425 MST1R 0.45 7.07 0.36 9.39e-12 Intelligence (multi-trait analysis); CRC cis rs9303280 0.837 rs907092 chr17:37922259 A/G cg20243544 chr17:37824526 PNMT -0.38 -5.92 -0.31 8.24e-9 Self-reported allergy; CRC cis rs9467711 0.606 rs2073527 chr6:26374978 T/C cg14345882 chr6:26364793 BTN3A2 0.64 5.63 0.3 3.85e-8 Autism spectrum disorder or schizophrenia; CRC trans rs6546324 0.625 rs6730286 chr2:67848054 C/T cg00907274 chr3:27498161 SLC4A7 -0.49 -6.26 -0.33 1.21e-9 Endometriosis; CRC cis rs9910055 0.529 rs575798 chr17:42181796 A/C cg10896456 chr17:42255109 ASB16;C17orf65 -0.37 -5.68 -0.3 2.94e-8 Total body bone mineral density; CRC cis rs425277 1.000 rs196128 chr1:2078444 T/G cg24578937 chr1:2090814 PRKCZ 0.66 11.79 0.54 5.46e-27 Height; CRC cis rs7208859 0.623 rs216423 chr17:28942109 G/C cg26176469 chr17:28951361 LRRC37B2 0.53 5.85 0.31 1.2e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs9308731 0.623 rs2241841 chr2:111879467 G/A cg04202892 chr2:111875749 ACOXL 0.43 6.91 0.36 2.51e-11 Chronic lymphocytic leukemia; CRC cis rs950027 0.620 rs1617634 chr15:45615578 A/G cg21132104 chr15:45694354 SPATA5L1 0.4 5.63 0.3 3.9e-8 Response to fenofibrate (adiponectin levels); CRC cis rs78456975 0.739 rs13405352 chr2:1518726 C/T cg12573674 chr2:1569213 NA -0.65 -7.36 -0.38 1.5e-12 Placebo response in major depressive disorder (% change in symptom score); CRC cis rs12594515 1.000 rs8025258 chr15:45987554 C/A cg01629716 chr15:45996671 NA 0.41 8.46 0.42 9.03e-16 Waist circumference;Weight; CRC cis rs9399137 0.507 rs11757723 chr6:135291293 C/T cg22676075 chr6:135203613 NA 0.58 8.73 0.43 1.3e-16 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; CRC cis rs2882667 0.964 rs12055237 chr5:138307306 A/G cg09476006 chr5:138032270 NA 0.49 8.18 0.41 6.47e-15 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs9549367 0.789 rs2287247 chr13:113889212 A/G cg18105134 chr13:113819100 PROZ -0.72 -11.03 -0.52 2.81e-24 Platelet distribution width; CRC cis rs9916302 0.851 rs11078906 chr17:37662767 C/T cg03013999 chr17:37608204 MED1 0.45 6.87 0.35 3.22e-11 Glomerular filtration rate (creatinine); CRC cis rs453301 0.571 rs2929305 chr8:9085217 G/A cg08975724 chr8:8085496 FLJ10661 -0.38 -5.91 -0.31 8.39e-9 Joint mobility (Beighton score); CRC cis rs57994353 0.760 rs4413892 chr9:139330158 G/A cg14119001 chr9:139324193 INPP5E -0.47 -6.71 -0.35 8.56e-11 Eosinophil counts;Cutaneous squamous cell carcinoma; CRC cis rs1788820 0.917 rs1788826 chr18:21154024 G/A cg14672496 chr18:21087552 C18orf8 0.51 8.95 0.44 2.6e-17 Body mass index; CRC cis rs4478858 0.684 rs7528066 chr1:31749092 C/G cg00250761 chr1:31883323 NA -0.44 -8.59 -0.43 3.52e-16 Alcohol dependence; CRC cis rs11711311 0.911 rs13321446 chr3:113522544 T/C cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.56 -7.56 -0.38 4.06e-13 IgG glycosylation; CRC cis rs13217239 0.646 rs12201393 chr6:26975690 C/A cg05192639 chr6:26864778 GUSBL1 0.31 6.01 0.31 5.05e-9 Schizophrenia; CRC cis rs931127 0.502 rs1466462 chr11:65419364 C/G cg27068330 chr11:65405492 SIPA1 0.65 10.15 0.49 3.18e-21 Systemic lupus erythematosus; CRC cis rs853679 0.517 rs9380057 chr6:28104634 G/T cg02683197 chr6:28174875 NA 0.85 10.52 0.5 1.71e-22 Depression; CRC trans rs61931739 0.500 rs11053198 chr12:34444013 G/C cg13010199 chr12:38710504 ALG10B 0.46 6.52 0.34 2.6200000000000003e-10 Morning vs. evening chronotype; CRC cis rs1448094 0.511 rs10779207 chr12:86152913 A/G cg06740227 chr12:86229804 RASSF9 -0.38 -5.78 -0.3 1.74e-8 Major depressive disorder; CRC cis rs7605827 0.930 rs11694458 chr2:15530469 C/G cg19274914 chr2:15703543 NA 0.39 5.88 0.31 9.87e-9 Educational attainment (years of education); CRC cis rs7811142 0.830 rs78256546 chr7:99952970 A/G cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.73 10.04 0.48 7.2e-21 Platelet count; CRC cis rs5769707 0.967 rs763127 chr22:50006078 C/T cg10356904 chr22:49881777 NA -0.32 -6.0 -0.31 5.27e-9 Monocyte count;Monocyte percentage of white cells; CRC cis rs9326248 1.000 rs664082 chr11:117071070 C/G cg11861562 chr11:117069780 TAGLN 0.42 9.34 0.46 1.53e-18 Blood protein levels; CRC cis rs4713118 0.615 rs9295747 chr6:27736993 G/T cg03623178 chr6:28175578 NA -0.6 -8.34 -0.42 2.12e-15 Parkinson's disease; CRC cis rs3768617 0.811 rs12043805 chr1:183008150 T/A ch.1.3577855R chr1:183094577 LAMC1 0.61 9.01 0.45 1.67e-17 Fuchs's corneal dystrophy; CRC cis rs10227331 0.934 rs2302447 chr7:157295985 A/T cg04156418 chr7:157293606 NA 0.34 6.0 0.31 5.29e-9 Inattentive symptoms; CRC cis rs881375 0.678 rs10985102 chr9:123707497 G/A cg14255062 chr9:123606675 PSMD5;LOC253039 0.37 5.97 0.31 6.28e-9 Rheumatoid arthritis; CRC cis rs4819052 0.851 rs2838837 chr21:46665988 C/T cg11663144 chr21:46675770 NA -0.83 -14.08 -0.61 1.46e-35 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs1862618 0.853 rs863840 chr5:56128999 C/G cg22800045 chr5:56110881 MAP3K1 0.55 6.05 0.32 3.94e-9 Initial pursuit acceleration; CRC cis rs736408 0.812 rs4687654 chr3:52827566 G/A cg15147215 chr3:52552868 STAB1 -0.54 -8.01 -0.4 2.07e-14 Bipolar disorder; CRC cis rs2635047 1.000 rs2684818 chr18:44712965 C/T cg19077165 chr18:44547161 KATNAL2 -0.48 -7.76 -0.39 1.06e-13 Educational attainment; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg06988368 chr1:147142773 ACP6 0.4 6.86 0.35 3.39e-11 Liver disease severity in Alagille syndrome; CRC cis rs3845702 1.000 rs9989852 chr2:180839707 G/A cg23417306 chr2:180868811 CWC22 -0.45 -6.09 -0.32 3.1e-9 Schizophrenia; CRC cis rs12044355 0.927 rs61835384 chr1:231833422 T/C cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX 0.49 6.74 0.35 7.06e-11 Alzheimer's disease; CRC cis rs7762018 1.000 rs1127489 chr6:170107702 C/T cg17545662 chr6:170176663 C6orf70 0.52 5.79 0.3 1.63e-8 Thiazide-induced adverse metabolic effects in hypertensive patients; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg26259546 chr3:57113458 ARHGEF3 0.44 6.57 0.34 1.94e-10 Intelligence (multi-trait analysis); CRC cis rs2204008 0.774 rs8189620 chr12:38241621 A/G cg26384229 chr12:38710491 ALG10B 0.69 9.22 0.45 3.69e-18 Bladder cancer; CRC cis rs4253772 0.530 rs6008623 chr22:46710024 G/A cg03482458 chr22:46692211 CN5H6.4;GTSE1 0.5 5.8 0.3 1.57e-8 LDL cholesterol;Cholesterol, total; CRC cis rs6952808 0.895 rs12669518 chr7:1921429 G/C cg02951883 chr7:2050386 MAD1L1 -0.68 -11.45 -0.53 9.17e-26 Bipolar disorder and schizophrenia; CRC cis rs3091242 0.933 rs35497030 chr1:25783066 A/G cg27572855 chr1:25598939 RHD -0.35 -5.99 -0.31 5.49e-9 Erythrocyte sedimentation rate; CRC cis rs3785574 0.962 rs2247435 chr17:61892862 G/A cg06873352 chr17:61820015 STRADA 0.49 7.77 0.39 1e-13 Height; CRC cis rs3096299 0.606 rs4785674 chr16:89536613 A/G cg05320533 chr16:89541815 ANKRD11 -0.44 -6.24 -0.33 1.32e-9 Multiple myeloma (IgH translocation); CRC cis rs4665809 0.590 rs1560865 chr2:26452197 C/A cg25036284 chr2:26402008 FAM59B -0.65 -8.57 -0.43 4.22e-16 Gut microbiome composition (summer); CRC cis rs67311347 1.000 rs9835219 chr3:40424093 C/T cg09455208 chr3:40491958 NA 0.44 8.9 0.44 3.72e-17 Renal cell carcinoma; CRC cis rs4664293 0.647 rs6711049 chr2:160441145 G/C cg08347373 chr2:160653686 CD302 -0.38 -6.48 -0.34 3.42e-10 Monocyte percentage of white cells; CRC cis rs7811142 0.779 rs77370288 chr7:99947897 A/T cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.63 8.02 0.4 1.82e-14 Platelet count; CRC cis rs9487051 0.872 rs9386789 chr6:109603218 A/G cg21918786 chr6:109611834 NA -0.43 -7.78 -0.39 9.32e-14 Reticulocyte fraction of red cells; CRC cis rs7224737 1.000 rs9889640 chr17:40293497 C/T cg02228675 chr17:40259724 DHX58 -0.48 -6.8 -0.35 5.05e-11 Fibrinogen levels; CRC cis rs7666738 0.830 rs1896154 chr4:99021161 T/C cg17366294 chr4:99064904 C4orf37 0.43 7.29 0.37 2.28e-12 Colonoscopy-negative controls vs population controls; CRC cis rs7572644 0.723 rs7578052 chr2:28318879 G/A cg27432699 chr2:27873401 GPN1 0.41 5.67 0.3 3.07e-8 Response to carboplatin and paclitaxel in ovarian cancer (Caspase 3/7 EC50); CRC cis rs6088580 0.634 rs6087577 chr20:32955423 C/T cg24642439 chr20:33292090 TP53INP2 0.37 6.21 0.32 1.58e-9 Glomerular filtration rate (creatinine); CRC cis rs1448094 0.511 rs17280643 chr12:86210154 C/T cg02569458 chr12:86230093 RASSF9 -0.44 -7.63 -0.39 2.52e-13 Major depressive disorder; CRC cis rs9322193 0.884 rs10872648 chr6:150079835 A/G cg13206674 chr6:150067644 NUP43 0.66 9.38 0.46 1.12e-18 Lung cancer; CRC cis rs62408225 1.000 rs55881869 chr6:90968025 C/A cg06866423 chr6:90926672 BACH2 0.47 7.8 0.4 8.11e-14 Eosinophil counts;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC cis rs6762 0.719 rs1130698 chr11:838542 C/T cg07691484 chr11:842764 TSPAN4;POLR2L -0.56 -8.0 -0.4 2.14e-14 Mean platelet volume; CRC cis rs4665809 0.938 rs35844686 chr2:26304949 A/G cg04944784 chr2:26401820 FAM59B 0.68 7.79 0.39 8.9e-14 Gut microbiome composition (summer); CRC cis rs4713118 0.513 rs156734 chr6:28007357 A/C cg21251018 chr6:28226885 NKAPL 0.48 7.52 0.38 5.31e-13 Parkinson's disease; CRC cis rs9858542 0.953 rs6766131 chr3:49538932 T/C cg07274523 chr3:49395745 GPX1 0.46 6.23 0.32 1.43e-9 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg04567173 chr4:25379221 ANAPC4 -0.43 -6.57 -0.34 1.97e-10 Myopia (pathological); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg04575144 chr19:4067379 ZBTB7A 0.49 8.17 0.41 6.76e-15 Liver disease severity in Alagille syndrome; CRC trans rs6601327 0.898 rs1458942 chr8:9406602 C/T cg16141378 chr3:129829833 LOC729375 0.44 6.21 0.32 1.62e-9 Multiple myeloma (hyperdiploidy); CRC cis rs9903692 0.505 rs208009 chr17:46229691 C/T cg10706073 chr17:46328419 SKAP1 0.59 6.36 0.33 6.7e-10 Pulse pressure; CRC cis rs6860806 0.695 rs11952099 chr5:131576772 A/G cg09877947 chr5:131593287 PDLIM4 0.47 8.93 0.44 3.07e-17 Breast cancer; CRC cis rs9811920 0.609 rs793447 chr3:99598278 A/G cg07805332 chr3:99536008 MIR548G;C3orf26 -0.51 -7.68 -0.39 1.84e-13 Axial length; CRC cis rs7208859 0.623 rs56325146 chr17:29151024 T/C cg13385521 chr17:29058706 SUZ12P 0.67 7.76 0.39 1.06e-13 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs262150 0.567 rs2527177 chr7:158804737 T/C cg12590608 chr7:158785262 NA 0.32 5.61 0.3 4.22e-8 Facial morphology (factor 20); CRC cis rs10504229 1.000 rs73607863 chr8:58170178 A/G cg02290350 chr8:58132656 NA -0.42 -5.96 -0.31 6.62e-9 Developmental language disorder (linguistic errors); CRC cis rs11212617 0.901 rs10789656 chr11:108024336 T/C cg14761454 chr11:108092087 ATM;NPAT 0.42 6.07 0.32 3.58e-9 Response to metformin in type 2 diabetes (glycemic); CRC cis rs13082711 0.911 rs6777272 chr3:27488310 T/G cg02860705 chr3:27208620 NA 0.63 8.89 0.44 4.23e-17 Systolic blood pressure;Diastolic blood pressure;Blood pressure; CRC cis rs3768617 0.510 rs3768621 chr1:183090057 C/T ch.1.3577855R chr1:183094577 LAMC1 0.89 15.86 0.66 1.84e-42 Fuchs's corneal dystrophy; CRC cis rs2243480 1.000 rs35735127 chr7:65300423 G/T cg12463550 chr7:65579703 CRCP 0.67 6.15 0.32 2.2e-9 Diabetic kidney disease; CRC cis rs919433 0.680 rs2605039 chr2:198362851 C/A cg10820045 chr2:198174542 NA 0.39 6.51 0.34 2.74e-10 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC cis rs172166 0.652 rs476167 chr6:28065888 T/C cg06470822 chr6:28175283 NA 0.82 12.25 0.56 1.14e-28 Cardiac Troponin-T levels; CRC cis rs7666738 0.861 rs10018654 chr4:99002226 A/G cg05340658 chr4:99064831 C4orf37 0.61 9.54 0.47 3.44e-19 Colonoscopy-negative controls vs population controls; CRC cis rs6502050 0.835 rs8077772 chr17:80117220 A/G cg25804541 chr17:80189381 SLC16A3 0.32 6.29 0.33 1.03e-9 Life satisfaction; CRC cis rs6500395 0.925 rs9933148 chr16:48672099 C/T cg04672837 chr16:48644449 N4BP1 0.45 6.71 0.35 8.38e-11 Response to tocilizumab in rheumatoid arthritis; CRC cis rs911555 0.723 rs56227024 chr14:103861706 A/G cg12935359 chr14:103987150 CKB 0.52 8.39 0.42 1.46e-15 Intelligence (multi-trait analysis); CRC cis rs6456156 1.000 rs9457274 chr6:167520865 G/T cg07741184 chr6:167504864 NA 0.36 6.37 0.33 6.36e-10 Primary biliary cholangitis; CRC trans rs11165623 0.564 rs6593611 chr1:97001996 T/C cg10631902 chr5:14652156 NA -0.39 -6.62 -0.34 1.42e-10 Hip circumference;Waist circumference; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg09133562 chr1:20126395 TMCO4 0.37 6.13 0.32 2.58e-9 Liver disease severity in Alagille syndrome; CRC cis rs8114671 0.562 rs959829 chr20:33346047 T/C cg07148914 chr20:33460835 GGT7 -0.4 -6.18 -0.32 1.89e-9 Height; CRC cis rs2153535 0.580 rs6921964 chr6:8446395 A/G cg07606381 chr6:8435919 SLC35B3 0.68 10.98 0.52 4.2e-24 Motion sickness; CRC cis rs1799949 0.965 rs8176198 chr17:41230537 A/T cg23758822 chr17:41437982 NA 0.83 14.87 0.63 1.25e-38 Menopause (age at onset); CRC cis rs6502050 0.835 rs12950475 chr17:80118924 T/C cg02741985 chr17:80059408 CCDC57 0.43 7.15 0.37 5.59e-12 Life satisfaction; CRC cis rs10870270 0.957 rs3753008 chr10:133785129 A/C cg17892150 chr10:133769511 PPP2R2D -0.76 -11.62 -0.54 2.12e-26 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; CRC cis rs875971 0.929 rs12535036 chr7:65964063 G/T cg00343986 chr7:65444356 GUSB 0.44 6.47 0.34 3.56e-10 Aortic root size; CRC cis rs7089973 0.872 rs12773943 chr10:116631184 G/A cg03647239 chr10:116582469 FAM160B1 0.41 5.62 0.3 4.06e-8 Bipolar disorder or attention deficit hyperactivity disorder; CRC cis rs6502050 0.605 rs35158616 chr17:80094480 A/G cg25804541 chr17:80189381 SLC16A3 -0.3 -5.72 -0.3 2.36e-8 Life satisfaction; CRC cis rs735396 1.000 rs2259816 chr12:121435587 A/C cg02403541 chr12:121454288 C12orf43 -0.43 -6.53 -0.34 2.52e-10 N-glycan levels; CRC cis rs478304 0.654 rs11601509 chr11:65456864 T/C cg27068330 chr11:65405492 SIPA1 -0.66 -9.82 -0.48 4.02e-20 Acne (severe); CRC cis rs9894429 0.646 rs6565612 chr17:79602820 C/T cg21984481 chr17:79567631 NPLOC4 0.44 7.82 0.4 7.35e-14 Eye color traits; CRC cis rs6570726 0.935 rs454370 chr6:145846729 T/G cg23711669 chr6:146136114 FBXO30 0.68 12.3 0.56 7.07e-29 Lobe attachment (rater-scored or self-reported); CRC cis rs10905065 0.931 rs10795510 chr10:5758827 G/A cg11519256 chr10:5708881 ASB13 0.43 6.12 0.32 2.67e-9 Menopause (age at onset); CRC cis rs16975963 0.644 rs73031322 chr19:38040879 C/A cg15135657 chr19:38346511 NA -0.45 -6.25 -0.33 1.25e-9 Longevity; CRC cis rs10504229 0.683 rs16921843 chr8:58113338 T/C cg24829409 chr8:58192753 C8orf71 -0.54 -7.88 -0.4 4.9e-14 Developmental language disorder (linguistic errors); CRC cis rs3892630 0.818 rs80137870 chr19:33182750 C/T cg22980127 chr19:33182716 NUDT19 0.91 11.12 0.52 1.3e-24 Red blood cell traits; CRC cis rs7605827 0.930 rs4668911 chr2:15610650 A/C cg19274914 chr2:15703543 NA 0.39 5.9 0.31 8.83e-9 Educational attainment (years of education); CRC cis rs10911232 0.507 rs4652769 chr1:183009196 T/C ch.1.3577855R chr1:183094577 LAMC1 0.85 14.9 0.63 1.01e-38 Hypertriglyceridemia; CRC cis rs780094 0.544 rs780108 chr2:27684957 T/C cg17158414 chr2:27665306 KRTCAP3 -0.28 -6.06 -0.32 3.64e-9 Calcium levels;Fasting blood insulin;Metabolic traits;Triglyceride levels;Fasting plasma glucose;Urate levels in overweight individuals;Urate levels in obese individuals;Uric acid levels;Height;Age-related diseases, mortality and associated endophenotypes;Renal underexcretion gout;Fasting blood glucose (BMI interaction);Urate levels;Gondoic acid (20:1n-9) levels;Fasting blood insulin (BMI interaction);Triglycerides;Plasma omega-3 polyunsaturated fatty acid levels (docosapentaenoic acid);Type 2 diabetes;Nonalcoholic fatty liver disease;Hypertriglyceridemia;C-reactive protein;Age-related disease endophenotypes;LDL cholesterol;Metabolic syndrome;Crohn's disease;Alcohol consumption (drinks per week);Homeostasis model assessment of insulin resistance;Alcohol consumption;Red blood cell count;Fasting blood glucose; CRC trans rs57221529 0.709 rs72703034 chr5:577101 C/T cg25482853 chr8:67687455 SGK3 1.25 14.99 0.64 4.45e-39 Lung disease severity in cystic fibrosis; CRC cis rs6700896 0.932 rs6678033 chr1:66077624 G/A cg04111102 chr1:66153794 NA 0.35 6.26 0.33 1.22e-9 C-reactive protein;Mean corpuscular volume;Mean corpuscular hemoglobin; CRC trans rs3733585 0.699 rs7658170 chr4:9966593 C/T cg26043149 chr18:55253948 FECH 0.46 6.92 0.36 2.34e-11 Cleft plate (environmental tobacco smoke interaction); CRC cis rs7091068 0.721 rs618951 chr10:95404967 A/G cg20715218 chr10:95462985 C10orf4 -0.47 -5.66 -0.3 3.29e-8 Urinary tract infection frequency; CRC cis rs208520 1.000 rs12191598 chr6:66983962 T/C cg07460842 chr6:66804631 NA 0.91 11.17 0.52 8.75e-25 Exhaled nitric oxide output; CRC cis rs17125944 0.615 rs12589020 chr14:53312002 C/T cg00686598 chr14:53173677 PSMC6 0.76 6.6 0.34 1.62e-10 Alzheimer's disease (late onset); CRC trans rs853679 0.882 rs4713139 chr6:28092685 C/T cg06606381 chr12:133084897 FBRSL1 -0.92 -7.56 -0.38 4e-13 Depression; CRC cis rs9467711 0.591 rs9461219 chr6:25836927 C/G cg08501292 chr6:25962987 TRIM38 -1.11 -9.86 -0.48 2.84e-20 Autism spectrum disorder or schizophrenia; CRC cis rs11971779 0.715 rs6943973 chr7:139029893 G/C cg23387468 chr7:139079360 LUC7L2 0.41 7.05 0.36 1.03e-11 Diisocyanate-induced asthma; CRC cis rs7829975 0.807 rs519019 chr8:8595104 A/T cg06636001 chr8:8085503 FLJ10661 -0.6 -9.44 -0.46 7.2e-19 Mood instability; CRC cis rs282587 0.569 rs409896 chr13:113400338 G/T cg04656015 chr13:113407548 ATP11A 0.62 7.65 0.39 2.27e-13 Glycated hemoglobin levels; CRC cis rs2073300 0.609 rs1936011 chr20:23341912 G/C cg12062639 chr20:23401060 NAPB 0.68 6.06 0.32 3.73e-9 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs4713118 0.513 rs149951 chr6:28033087 T/C cg10876282 chr6:28092338 ZSCAN16 0.47 6.43 0.33 4.62e-10 Parkinson's disease; CRC cis rs7666738 0.830 rs10031190 chr4:98908683 C/A cg05340658 chr4:99064831 C4orf37 0.56 8.42 0.42 1.21e-15 Colonoscopy-negative controls vs population controls; CRC cis rs9341808 0.935 rs9448894 chr6:80837253 G/T cg08355045 chr6:80787529 NA 0.37 6.15 0.32 2.21e-9 Sitting height ratio; CRC cis rs2046867 0.862 rs62252362 chr3:72855218 A/G cg25664220 chr3:72788482 NA -0.42 -6.45 -0.33 4.03e-10 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg02269272 chr17:17991219 DRG2 0.43 6.03 0.32 4.33e-9 Response to antipsychotic treatment; CRC cis rs10504229 0.679 rs4737454 chr8:58033965 A/T cg02725872 chr8:58115012 NA -0.37 -6.55 -0.34 2.16e-10 Developmental language disorder (linguistic errors); CRC cis rs7613875 0.620 rs13079006 chr3:49996924 G/T cg05623727 chr3:50126028 RBM5 0.61 10.64 0.51 6.26e-23 Body mass index; CRC cis rs736408 0.522 rs11130310 chr3:52674667 C/T cg18404041 chr3:52824283 ITIH1 -0.41 -8.48 -0.42 7.92e-16 Bipolar disorder; CRC cis rs4654899 1.000 rs6426660 chr1:21361640 A/G cg02927042 chr1:21476669 EIF4G3 -0.46 -7.37 -0.38 1.43e-12 Superior frontal gyrus grey matter volume; CRC cis rs6424115 0.830 rs6672157 chr1:24198840 C/G cg10978503 chr1:24200527 CNR2 0.61 11.23 0.53 5.62e-25 Immature fraction of reticulocytes; CRC cis rs10097731 0.901 rs10464932 chr8:82042901 T/G cg25230327 chr8:82042993 NA -0.93 -13.69 -0.6 4.32e-34 Serum total protein level; CRC trans rs12744310 0.887 rs35690915 chr1:41797999 T/C cg19175123 chr10:103411746 FBXW4 0.44 6.01 0.31 4.87e-9 Cognitive ability (multi-trait analysis);Intelligence;Cognitive ability; CRC cis rs6952808 0.501 rs4721429 chr7:2171704 T/C cg08027265 chr7:2291960 NA -0.36 -5.78 -0.3 1.77e-8 Bipolar disorder and schizophrenia; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg07509094 chr11:60674167 PRPF19 0.48 6.75 0.35 6.66e-11 Response to antipsychotic treatment; CRC cis rs60843830 1.000 rs11553746 chr2:272203 C/T cg00108164 chr2:264199 ACP1;SH3YL1 0.62 9.67 0.47 1.25e-19 Spherical equivalent (joint analysis main effects and education interaction); CRC cis rs3796619 1.000 rs4974638 chr4:1099201 G/A cg27284194 chr4:1044797 NA 0.43 6.6 0.34 1.65e-10 Recombination rate (males); CRC cis rs6061231 1.000 rs67941642 chr20:60958108 C/T cg24112000 chr20:60950667 NA -0.64 -10.55 -0.5 1.31e-22 Colorectal cancer; CRC cis rs798554 0.959 rs798558 chr7:2758935 T/G cg04166393 chr7:2884313 GNA12 0.45 6.13 0.32 2.56e-9 Height; CRC cis rs9303401 0.614 rs34683543 chr17:56520036 C/A cg10487724 chr17:56770010 TEX14;RAD51C 0.74 9.3 0.46 1.96e-18 Cognitive test performance; CRC cis rs7703744 0.597 rs73237297 chr5:118691121 G/T cg17471836 chr5:118691007 TNFAIP8 0.42 6.02 0.32 4.61e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs4129767 0.647 rs1976703 chr17:76401328 C/T cg02319466 chr17:76381040 PGS1 0.36 5.63 0.3 3.82e-8 HDL cholesterol; CRC cis rs861020 0.630 rs9308411 chr1:210005713 C/T cg05527609 chr1:210001259 C1orf107 0.72 10.02 0.48 8.66e-21 Orofacial clefts; CRC cis rs274567 0.501 rs272856 chr5:131687081 G/C cg18301423 chr5:131593218 PDLIM4 0.38 6.24 0.33 1.32e-9 Blood metabolite levels; CRC cis rs561341 1.000 rs757009 chr17:30243937 A/G cg12193833 chr17:30244370 NA -0.57 -7.67 -0.39 1.94e-13 Hip circumference adjusted for BMI; CRC cis rs7072216 0.763 rs10883092 chr10:100167276 A/C cg26618903 chr10:100175079 PYROXD2 -0.53 -8.78 -0.44 9.08e-17 Metabolite levels; CRC cis rs7666738 0.830 rs7662218 chr4:98983126 T/G cg05340658 chr4:99064831 C4orf37 0.61 9.56 0.47 2.93e-19 Colonoscopy-negative controls vs population controls; CRC cis rs929354 0.772 rs3802120 chr7:156977794 C/T cg17757837 chr7:157058334 UBE3C 0.74 12.57 0.57 7.46e-30 Body mass index; CRC cis rs2842992 0.789 rs7765490 chr6:160204326 C/T cg11366901 chr6:160182831 ACAT2 0.97 14.88 0.63 1.16e-38 Age-related macular degeneration (geographic atrophy); CRC cis rs1559088 0.749 rs10405757 chr19:33616526 C/A cg27124370 chr19:33622961 WDR88 0.42 5.81 0.31 1.45e-8 Bone ultrasound measurement (broadband ultrasound attenuation); CRC trans rs2303319 0.504 rs62188988 chr2:162531068 T/C cg01422129 chr2:677375 TMEM18 -0.7 -6.09 -0.32 3.21e-9 Cognitive function; CRC cis rs294883 0.827 rs1875815 chr6:159720280 C/T cg14500486 chr6:159655392 FNDC1 -0.34 -5.65 -0.3 3.54e-8 Coronary artery disease; CRC cis rs6570726 0.755 rs2103633 chr6:145894021 C/T cg23711669 chr6:146136114 FBXO30 0.69 11.52 0.54 4.94e-26 Lobe attachment (rater-scored or self-reported); CRC cis rs7618915 0.547 rs2286800 chr3:52778051 C/T cg18404041 chr3:52824283 ITIH1 -0.43 -8.89 -0.44 4.01e-17 Bipolar disorder; CRC cis rs9549260 0.755 rs1413482 chr13:41218451 C/T cg21288729 chr13:41239152 FOXO1 0.49 7.68 0.39 1.82e-13 Red blood cell count; CRC cis rs2898681 0.581 rs731073 chr4:53680090 A/G cg00338735 chr4:53728038 RASL11B 0.39 5.92 0.31 8.08e-9 Optic nerve measurement (cup area); CRC cis rs7666738 0.830 rs6834014 chr4:98951431 G/A cg17366294 chr4:99064904 C4orf37 0.43 7.34 0.38 1.69e-12 Colonoscopy-negative controls vs population controls; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg03539474 chr2:172751088 SLC25A12 0.44 6.36 0.33 6.86e-10 Response to antipsychotic treatment; CRC cis rs853679 0.546 rs200995 chr6:27813694 C/T cg23259851 chr6:27775964 HIST1H2AI;HIST1H2BL -0.69 -5.85 -0.31 1.21e-8 Depression; CRC cis rs56307353 0.652 rs4807191 chr19:1990309 C/T cg02376178 chr19:1969988 CSNK1G2 -0.59 -9.48 -0.46 5.38e-19 Coronary artery disease; CRC cis rs9311676 0.609 rs55845662 chr3:58424899 A/C cg06643156 chr3:58380774 PXK 0.43 6.53 0.34 2.5e-10 Systemic lupus erythematosus; CRC cis rs1153858 1.000 rs2056493 chr15:45648272 A/G cg21132104 chr15:45694354 SPATA5L1 0.59 8.71 0.43 1.54e-16 Homoarginine levels; CRC cis rs9549367 0.789 rs9549716 chr13:113908478 G/A cg18105134 chr13:113819100 PROZ -0.75 -11.01 -0.52 3.14e-24 Platelet distribution width; CRC cis rs7089973 0.584 rs4752255 chr10:116576790 C/T cg23260525 chr10:116636907 FAM160B1 0.35 8.09 0.41 1.15e-14 Bipolar disorder or attention deficit hyperactivity disorder; CRC cis rs13082711 0.595 rs13075389 chr3:27339586 C/T cg02860705 chr3:27208620 NA 0.81 10.61 0.51 7.87e-23 Systolic blood pressure;Diastolic blood pressure;Blood pressure; CRC trans rs9956878 0.555 rs8085188 chr18:73544676 A/G cg20045888 chr4:151000084 DCLK2 -0.35 -6.01 -0.31 4.87e-9 Obesity-related traits; CRC cis rs2760061 0.583 rs1636195 chr1:228211589 T/C cg01200585 chr1:228362443 C1orf69 0.46 5.92 0.31 7.99e-9 Diastolic blood pressure; CRC cis rs13082711 0.516 rs13084067 chr3:27358935 A/T cg02860705 chr3:27208620 NA 0.69 9.39 0.46 1.02e-18 Systolic blood pressure;Diastolic blood pressure;Blood pressure; CRC trans rs7615952 0.512 rs11929125 chr3:125359443 G/A cg02560186 chr11:3602584 NA -0.63 -9.54 -0.47 3.23e-19 Blood pressure (smoking interaction); CRC cis rs6714710 0.603 rs11678591 chr2:98541001 T/C cg26665480 chr2:98280029 ACTR1B 0.53 7.41 0.38 1.08e-12 Posterior cortical atrophy and Alzheimer's disease; CRC cis rs5757676 0.858 rs6001585 chr22:39812986 G/T cg24399712 chr22:39784796 NA -0.39 -6.3 -0.33 9.32e-10 IgG glycosylation; CRC cis rs7616330 0.836 rs17008114 chr3:71045000 A/C cg01511742 chr3:71112437 FOXP1 -0.51 -6.19 -0.32 1.79e-9 QT interval; CRC cis rs6500395 1.000 rs12599744 chr16:48716729 G/A cg04672837 chr16:48644449 N4BP1 -0.45 -6.7 -0.35 9.21e-11 Response to tocilizumab in rheumatoid arthritis; CRC cis rs12142240 0.698 rs1053627 chr1:46827728 A/C cg14993813 chr1:46806288 NSUN4 -0.49 -6.22 -0.32 1.55e-9 Menopause (age at onset); CRC cis rs9549328 0.589 rs36164841 chr13:113616579 A/G cg08614441 chr13:113633676 MCF2L 0.4 6.97 0.36 1.69e-11 Systolic blood pressure; CRC cis rs2204008 0.774 rs8186954 chr12:38318566 C/A cg26384229 chr12:38710491 ALG10B 0.67 9.53 0.47 3.52e-19 Bladder cancer; CRC cis rs6952808 0.798 rs28970524 chr7:1927484 C/T cg14004847 chr7:1930337 MAD1L1 -0.43 -5.73 -0.3 2.25e-8 Bipolar disorder and schizophrenia; CRC cis rs6502050 0.835 rs6502059 chr17:80082886 T/C cg09264619 chr17:80180166 NA 0.36 6.08 0.32 3.4e-9 Life satisfaction; CRC cis rs939584 0.935 rs12993295 chr2:632808 G/T cg03610516 chr2:642275 NA 0.42 5.65 0.3 3.49e-8 Body mass index; CRC trans rs3780486 1.000 rs3780480 chr9:33163486 G/T cg04842962 chr6:43655489 MRPS18A 1.0 15.36 0.65 1.61e-40 IgG glycosylation; CRC trans rs1005277 0.579 rs2021649 chr10:38392122 C/T cg11292332 chr7:45801988 SEPT13 -0.36 -6.29 -0.33 9.88e-10 Extrinsic epigenetic age acceleration; CRC cis rs10256972 0.621 rs2363285 chr7:1091644 C/T cg16145915 chr7:1198662 ZFAND2A -0.31 -6.37 -0.33 6.24e-10 Longevity;Endometriosis; CRC cis rs939584 1.000 rs2867115 chr2:651382 T/C cg03610516 chr2:642275 NA -0.43 -5.94 -0.31 7.33e-9 Body mass index; CRC cis rs7927592 1.000 rs7927592 chr11:68369960 G/A cg16797656 chr11:68205561 LRP5 0.38 5.97 0.31 6.29e-9 Total body bone mineral density; CRC cis rs7552404 1.000 rs9662166 chr1:76235906 C/A cg10523679 chr1:76189770 ACADM 0.82 11.35 0.53 2.12e-25 Blood metabolite levels;Acylcarnitine levels; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg14385122 chr9:71320671 PIP5K1B -0.41 -6.2 -0.32 1.72e-9 Myopia (pathological); CRC cis rs11030122 0.661 rs10767811 chr11:4066398 G/A cg18678763 chr11:4115507 RRM1 -0.49 -7.89 -0.4 4.65e-14 Mean platelet volume;Platelet distribution width; CRC trans rs853679 0.599 rs156743 chr6:27967089 T/C cg06606381 chr12:133084897 FBRSL1 -0.8 -7.52 -0.38 5.2e-13 Depression; CRC cis rs10911251 0.528 rs10911255 chr1:183088868 G/C ch.1.3577855R chr1:183094577 LAMC1 0.89 15.86 0.66 1.84e-42 Colorectal cancer; CRC cis rs473651 0.777 rs550890 chr2:239332555 G/A cg18131467 chr2:239335373 ASB1 0.78 12.32 0.56 6.28e-29 Multiple system atrophy; CRC cis rs2274471 0.645 rs10974955 chr9:5090641 G/A cg03390472 chr9:5043263 JAK2 -0.6 -7.05 -0.36 1.07e-11 Crohn's disease; CRC cis rs1552244 1.000 rs6804473 chr3:10060425 C/T cg18598329 chr3:10140678 FANCD2;C3orf24 -0.88 -12.15 -0.56 2.53e-28 Alzheimer's disease; CRC trans rs3733585 0.699 rs6449171 chr4:9965998 C/T cg26043149 chr18:55253948 FECH 0.49 7.45 0.38 8.21e-13 Cleft plate (environmental tobacco smoke interaction); CRC cis rs208520 0.779 rs208451 chr6:66906155 G/A cg07460842 chr6:66804631 NA -0.92 -11.51 -0.54 5.56e-26 Exhaled nitric oxide output; CRC cis rs3099143 1.000 rs3102712 chr15:77058926 G/A cg21673338 chr15:77095150 SCAPER -0.73 -7.17 -0.37 5.04e-12 Recalcitrant atopic dermatitis; CRC cis rs17270561 0.609 rs4145217 chr6:25743997 T/C cg16482183 chr6:26056742 HIST1H1C 0.83 10.69 0.51 4.46e-23 Iron status biomarkers; CRC cis rs875971 0.862 rs709596 chr7:65825913 A/G cg18876405 chr7:65276391 NA 0.51 8.69 0.43 1.76e-16 Aortic root size; CRC cis rs6860806 0.661 rs4705927 chr5:131578608 C/G cg20512303 chr5:131592959 PDLIM4 0.34 6.63 0.34 1.41e-10 Breast cancer; CRC cis rs929354 0.772 rs933344 chr7:157011265 A/T cg17757837 chr7:157058334 UBE3C 0.74 12.62 0.57 4.92e-30 Body mass index; CRC cis rs5750830 0.595 rs4821892 chr22:39795683 G/C cg25459000 chr22:39777742 SYNGR1 -0.32 -5.67 -0.3 3.14e-8 Intelligence (multi-trait analysis); CRC cis rs853679 0.517 rs12174753 chr6:28042465 C/G cg12172441 chr6:28176163 NA 0.59 7.01 0.36 1.36e-11 Depression; CRC cis rs2836974 0.966 rs7283420 chr21:40666865 T/C cg11644478 chr21:40555479 PSMG1 0.69 9.77 0.47 5.67e-20 Cognitive function; CRC cis rs67311347 1.000 rs73078158 chr3:40472567 G/C cg09455208 chr3:40491958 NA 0.49 9.63 0.47 1.66e-19 Renal cell carcinoma; CRC cis rs3741151 0.687 rs724111 chr11:73238645 G/A cg17517138 chr11:73019481 ARHGEF17 0.98 8.0 0.4 2.12e-14 GIP levels in response to oral glucose tolerance test (120 minutes); CRC cis rs9309473 1.000 rs7576245 chr2:73829678 C/T cg20560298 chr2:73613845 ALMS1 -0.46 -5.68 -0.3 2.96e-8 Metabolite levels; CRC cis rs10504229 0.683 rs10504221 chr8:58140256 A/G cg24829409 chr8:58192753 C8orf71 -0.55 -8.03 -0.4 1.71e-14 Developmental language disorder (linguistic errors); CRC cis rs10504229 0.906 rs56130194 chr8:58197061 C/A cg21724239 chr8:58056113 NA 0.59 7.25 0.37 2.94e-12 Developmental language disorder (linguistic errors); CRC cis rs2032447 0.714 rs2051540 chr6:25947197 T/C cg12310025 chr6:25882481 NA -0.61 -8.82 -0.44 6.77e-17 Intelligence (multi-trait analysis); CRC cis rs514406 0.929 rs562178 chr1:53319562 T/C cg27535305 chr1:53392650 SCP2 -0.37 -6.91 -0.36 2.52e-11 Monocyte count; CRC cis rs728616 0.764 rs75385771 chr10:81692779 T/C cg11900509 chr10:81946545 ANXA11 -0.65 -6.71 -0.35 8.77e-11 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs763014 1.000 rs2269558 chr16:682250 C/T cg03804128 chr16:635623 NA 0.3 6.86 0.35 3.45e-11 Height; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg02208506 chr17:4634804 MED11 0.46 6.52 0.34 2.6200000000000003e-10 Response to antipsychotic treatment; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg05573837 chr3:42696434 ZBTB47 0.36 6.17 0.32 2.06e-9 Liver disease severity in Alagille syndrome; CRC cis rs34779708 0.931 rs12776390 chr10:35391535 T/G cg03585969 chr10:35415529 CREM 0.6 7.95 0.4 3.06e-14 Inflammatory bowel disease;Crohn's disease; CRC cis rs8177253 0.634 rs6798547 chr3:133448499 G/A cg01448562 chr3:133502909 NA -0.39 -6.26 -0.33 1.2e-9 Iron status biomarkers; CRC cis rs11148252 0.875 rs4885953 chr13:52976491 G/A cg12458913 chr13:53173898 NA 0.49 7.71 0.39 1.5e-13 Lewy body disease; CRC cis rs72634258 0.945 rs7522911 chr1:8097145 C/T cg00042356 chr1:8021962 PARK7 0.65 6.74 0.35 6.94e-11 Inflammatory bowel disease; CRC cis rs11764590 0.950 rs11514731 chr7:2051503 C/G cg21155852 chr7:2048760 MAD1L1 -0.52 -6.87 -0.35 3.24e-11 Neuroticism; CRC cis rs11785400 0.793 rs1056012 chr8:143740167 A/G cg10596483 chr8:143751796 JRK 0.44 5.88 0.31 9.91e-9 Schizophrenia; CRC cis rs57590327 0.503 rs13066091 chr3:81589912 T/C cg07356753 chr3:81810745 GBE1 -0.53 -6.97 -0.36 1.76e-11 Extraversion; CRC cis rs13256369 0.951 rs13259955 chr8:8565885 C/G cg18904891 chr8:8559673 CLDN23 0.55 7.42 0.38 9.97e-13 Obesity-related traits; CRC cis rs2456568 0.531 rs7105060 chr11:93661268 C/A cg26875233 chr11:93583750 C11orf90 -0.36 -6.9 -0.36 2.65e-11 Response to serotonin reuptake inhibitors in major depressive disorder; CRC cis rs939658 0.776 rs4778925 chr15:79443791 C/T cg17916960 chr15:79447300 NA -0.44 -7.08 -0.36 8.5e-12 Refractive error; CRC cis rs2276314 0.857 rs9960670 chr18:33577712 A/G cg19628046 chr18:33552617 C18orf21 0.55 7.15 0.37 5.81e-12 Endometriosis;Drug-induced torsades de pointes; CRC cis rs185694 0.947 rs169331 chr13:30878695 G/T cg04551440 chr13:30881194 KATNAL1 -0.64 -6.31 -0.33 9.21e-10 Antineutrophil cytoplasmic antibody-associated vasculitis; CRC cis rs4555082 0.915 rs2816632 chr14:105741355 C/T cg18132624 chr14:105716052 BTBD6;BRF1 0.34 5.86 0.31 1.14e-8 Mean platelet volume;Platelet distribution width; CRC trans rs877282 0.842 rs12357963 chr10:757562 C/T cg22713356 chr15:30763199 NA 1.24 14.62 0.63 1.19e-37 Uric acid levels; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg18149653 chr12:53267995 NA 0.43 6.23 0.32 1.45e-9 Intelligence (multi-trait analysis); CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg01839850 chr22:38240395 ANKRD54;MIR658 0.47 6.01 0.31 4.82e-9 Thyroid stimulating hormone; CRC cis rs10992471 0.603 rs1121978 chr9:95140351 T/G cg14631576 chr9:95140430 CENPP -0.4 -7.15 -0.37 5.48e-12 Visceral adipose tissue/subcutaneous adipose tissue ratio; CRC cis rs6963495 0.818 rs73190163 chr7:105157294 G/T cg02135003 chr7:105160482 PUS7 -0.9 -12.2 -0.56 1.71e-28 Bipolar disorder (body mass index interaction); CRC cis rs11203032 0.831 rs11203027 chr10:90956290 T/A cg16672925 chr10:90967113 CH25H 0.45 5.74 0.3 2.17e-8 Heart failure; CRC cis rs9467773 0.572 rs13213953 chr6:26594534 T/A cg09904177 chr6:26538194 HMGN4 0.6 8.55 0.43 4.76e-16 Intelligence (multi-trait analysis); CRC cis rs7927592 0.913 rs11228293 chr11:68384646 T/C cg01657329 chr11:68192670 LRP5 -0.46 -6.61 -0.34 1.51e-10 Total body bone mineral density; CRC cis rs9372498 0.536 rs9489450 chr6:118904385 G/A cg10217327 chr6:118973057 C6orf204 0.53 5.94 0.31 7.14e-9 Diastolic blood pressure; CRC cis rs4319547 0.626 rs12423420 chr12:122938466 G/A cg23029597 chr12:123009494 RSRC2 -0.47 -6.24 -0.33 1.38e-9 Body mass index; CRC cis rs6460942 0.915 rs62447641 chr7:12488764 G/A cg20607287 chr7:12443886 VWDE -0.66 -6.91 -0.36 2.56e-11 Coronary artery disease; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg03112782 chr1:37979729 MEAF6 0.47 6.31 0.33 9.14e-10 Thyroid stimulating hormone; CRC cis rs9463078 0.547 rs116177834 chr6:44738548 C/A cg25276700 chr6:44698697 NA 0.31 7.79 0.39 8.81e-14 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; CRC cis rs10256972 0.504 rs2949178 chr7:1209925 T/C cg18402987 chr7:1209562 NA 0.61 9.69 0.47 1.03e-19 Longevity;Endometriosis; CRC cis rs853679 0.882 rs9393908 chr6:28190830 T/A cg06470822 chr6:28175283 NA 0.86 6.93 0.36 2.27e-11 Depression; CRC cis rs6543140 0.964 rs11886793 chr2:103072220 T/G cg09003973 chr2:102972529 NA 0.41 5.83 0.31 1.33e-8 Blood protein levels; CRC cis rs2243480 0.908 rs2460431 chr7:65622846 A/G cg18252515 chr7:66147081 NA 1.23 14.38 0.62 9.77e-37 Diabetic kidney disease; CRC cis rs3008870 1.000 rs35365746 chr1:67438900 G/A cg08660285 chr1:67390436 MIER1;WDR78 -1.02 -14.92 -0.64 8.28e-39 Lymphocyte percentage of white cells; CRC cis rs2032447 0.869 rs199752 chr6:26012875 C/T cg26028573 chr6:26043587 HIST1H2BB 0.5 7.26 0.37 2.83e-12 Intelligence (multi-trait analysis); CRC cis rs4713118 0.515 rs9368549 chr6:28050047 T/A cg02683197 chr6:28174875 NA 0.8 10.0 0.48 9.7e-21 Parkinson's disease; CRC cis rs1005277 0.522 rs289650 chr10:37975505 G/T cg25517755 chr10:38738941 LOC399744 -0.43 -6.32 -0.33 8.7e-10 Extrinsic epigenetic age acceleration; CRC cis rs12188164 1.000 rs56104584 chr5:437542 T/C cg16322479 chr5:444228 EXOC3;C5orf55 0.48 7.84 0.4 6.19e-14 Cystic fibrosis severity; CRC cis rs8180040 0.932 rs1531875 chr3:47452786 G/A cg27129171 chr3:47204927 SETD2 0.52 8.07 0.41 1.35e-14 Colorectal cancer; CRC cis rs875971 0.767 rs61348003 chr7:66005934 C/T cg18876405 chr7:65276391 NA 0.52 8.32 0.42 2.41e-15 Aortic root size; CRC cis rs753778 0.963 rs3739234 chr8:142229178 G/A cg18755752 chr8:142205143 DENND3 -0.41 -5.79 -0.3 1.62e-8 Reticulocyte fraction of red cells;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; CRC cis rs4268898 0.722 rs7564420 chr2:24414002 C/T cg06627628 chr2:24431161 ITSN2 -0.5 -7.28 -0.37 2.55e-12 Asthma; CRC cis rs62229266 0.682 rs2835224 chr21:37370030 A/T cg08632701 chr21:37451849 NA -0.37 -5.61 -0.3 4.39e-8 Mitral valve prolapse; CRC cis rs6582630 0.533 rs4103689 chr12:38702980 A/C cg26384229 chr12:38710491 ALG10B 0.58 8.55 0.43 4.67e-16 Drug-induced liver injury (flucloxacillin); CRC trans rs9858213 1 rs9858213 chr3:49731861 G/T cg21582582 chr3:182698605 DCUN1D1 -0.54 -6.46 -0.34 3.77e-10 Educational attainment; CRC trans rs7395662 0.571 rs12421145 chr11:48624725 C/A cg03929089 chr4:120376271 NA -0.46 -6.52 -0.34 2.68e-10 HDL cholesterol; CRC cis rs10504229 0.817 rs114173899 chr8:58170640 G/T cg24829409 chr8:58192753 C8orf71 -0.68 -11.23 -0.53 5.45e-25 Developmental language disorder (linguistic errors); CRC cis rs597539 0.690 rs11228383 chr11:68623228 T/G cg04772025 chr11:68637568 NA 0.53 8.05 0.41 1.56e-14 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs9400239 0.584 rs1268177 chr6:109017322 A/G cg11073813 chr6:109029018 NA -0.38 -5.84 -0.31 1.23e-8 Waist circumference;Body mass index;BMI (adjusted for smoking behaviour); CRC cis rs8014671 0.597 rs1044527 chr14:70833819 C/G cg23609571 chr14:70655845 SLC8A3 -0.31 -6.24 -0.33 1.35e-9 Prostate cancer; CRC cis rs4268898 0.527 rs72789910 chr2:24388609 T/G cg06627628 chr2:24431161 ITSN2 -0.83 -11.2 -0.53 6.87e-25 Asthma; CRC cis rs6964587 0.692 rs4729025 chr7:91847504 C/T cg17063962 chr7:91808500 NA 0.64 10.38 0.5 5e-22 Breast cancer; CRC cis rs992157 0.735 rs13388024 chr2:219097773 A/G cg00012203 chr2:219082015 ARPC2 0.62 10.4 0.5 4.35e-22 Colorectal cancer; CRC trans rs16846053 0.792 rs72875528 chr2:162533523 C/T cg12500891 chr11:57225987 NA -0.67 -6.03 -0.32 4.51e-9 Blood osmolality (transformed sodium); CRC cis rs4975616 0.686 rs37011 chr5:1348798 A/T cg26373071 chr5:1325741 CLPTM1L 0.45 7.92 0.4 3.65e-14 Lung cancer; CRC cis rs7512552 0.803 rs2454286 chr1:150355538 G/A cg15654264 chr1:150340011 RPRD2 0.59 8.63 0.43 2.64e-16 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); CRC cis rs6460942 0.908 rs73677570 chr7:12280329 T/C cg06484146 chr7:12443880 VWDE -0.62 -6.5 -0.34 2.96e-10 Coronary artery disease; CRC cis rs10791323 0.604 rs2250025 chr11:133710914 G/A cg00579200 chr11:133705235 NA -0.39 -5.65 -0.3 3.48e-8 Childhood ear infection; CRC cis rs116095464 0.558 rs2162870 chr5:228129 G/A cg22496380 chr5:211416 CCDC127 -0.86 -10.04 -0.48 7.52e-21 Breast cancer; CRC cis rs10751667 0.666 rs10902255 chr11:967268 T/C ch.11.42038R chr11:967971 AP2A2 0.58 9.98 0.48 1.16e-20 Alzheimer's disease (late onset); CRC cis rs7618915 0.501 rs3755798 chr3:52741160 G/A cg18404041 chr3:52824283 ITIH1 -0.4 -8.38 -0.42 1.55e-15 Bipolar disorder; CRC trans rs7395662 0.500 rs1304199 chr11:48699032 A/G cg03929089 chr4:120376271 NA -0.48 -7.03 -0.36 1.19e-11 HDL cholesterol; CRC cis rs4076764 1.000 rs6683181 chr1:163417077 C/T cg06092702 chr1:163392909 NA -0.58 -9.22 -0.45 3.52e-18 Motion sickness; CRC cis rs6969780 1.000 rs739734 chr7:27159405 C/T cg26364809 chr7:27145159 NA -0.74 -6.62 -0.34 1.49e-10 Diastolic blood pressure;Blood pressure traits (multi-trait analysis);Systolic blood pressure;Hypertension; CRC trans rs1814175 0.817 rs12287396 chr11:49819798 G/C cg15704280 chr7:45808275 SEPT13 -0.99 -19.52 -0.73 6.34e-57 Height; CRC cis rs2860975 0.936 rs7904000 chr10:96767858 A/T cg09036531 chr10:96991505 NA -0.47 -6.33 -0.33 7.93e-10 Immune response to smallpox vaccine (IL-6); CRC cis rs875971 0.520 rs160645 chr7:65556307 A/G cg02869306 chr7:64672164 INTS4L1 0.44 6.33 0.33 7.85e-10 Aortic root size; CRC cis rs3733585 0.781 rs6449183 chr4:9970691 C/A cg00071950 chr4:10020882 SLC2A9 -0.6 -10.89 -0.51 8.39e-24 Cleft plate (environmental tobacco smoke interaction); CRC cis rs9549328 0.643 rs4907567 chr13:113617533 C/T cg24588162 chr13:113633484 MCF2L 0.36 6.52 0.34 2.68e-10 Systolic blood pressure; CRC cis rs2279817 1.000 rs2354290 chr1:18019861 A/G cg21791023 chr1:18019539 ARHGEF10L 0.47 6.05 0.32 3.85e-9 Neuroticism; CRC cis rs9522267 0.535 rs56330641 chr13:112233538 C/T cg26182253 chr13:112236782 NA 0.31 6.29 0.33 9.96e-10 Hepatitis; CRC cis rs1577917 0.771 rs7452605 chr6:86240951 A/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A 0.66 8.73 0.43 1.33e-16 Response to antipsychotic treatment; CRC cis rs2075371 1.000 rs2075372 chr7:133984432 C/T cg20476274 chr7:133979776 SLC35B4 0.82 15.11 0.64 1.57e-39 Mean platelet volume; CRC cis rs11098499 0.691 rs10028773 chr4:120265259 C/G cg09307838 chr4:120376055 NA -0.59 -9.13 -0.45 7.21e-18 Corneal astigmatism; CRC cis rs12042938 1.000 rs4366301 chr1:231806286 C/G cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.5 -6.97 -0.36 1.79e-11 Neuranatomic and neurocognitive phenotypes; CRC cis rs6684514 1.000 rs2241106 chr1:156218910 C/G cg16558208 chr1:156270281 VHLL 0.62 9.72 0.47 8.72e-20 Mean corpuscular hemoglobin concentration;Glycated hemoglobin levels; CRC cis rs769267 0.965 rs2965188 chr19:19522557 G/A cg03709012 chr19:19516395 GATAD2A 0.72 11.2 0.53 6.93e-25 Tonsillectomy; CRC cis rs12912251 0.591 rs2643216 chr15:39003809 C/G cg10631289 chr15:39006617 NA -0.46 -5.78 -0.3 1.72e-8 Bipolar disorder;Bipolar disorder or major depressive disorder (combined); CRC cis rs1691799 0.867 rs1168309 chr12:66726439 A/G cg16791601 chr12:66731901 HELB 0.71 12.22 0.56 1.39e-28 White blood cell count (basophil); CRC cis rs7833790 0.676 rs7834555 chr8:82697625 A/G cg17211192 chr8:82754475 SNX16 -0.46 -6.21 -0.32 1.61e-9 Diastolic blood pressure; CRC cis rs1005277 0.579 rs2505196 chr10:38393563 G/A cg25427524 chr10:38739819 LOC399744 -0.77 -13.64 -0.6 6.85e-34 Extrinsic epigenetic age acceleration; CRC cis rs6502050 0.842 rs9894129 chr17:80075700 A/G cg13198984 chr17:80129470 CCDC57 -0.48 -8.57 -0.43 3.99e-16 Life satisfaction; CRC cis rs1401999 1.000 rs1533684 chr3:183635815 A/G cg05044414 chr3:183734942 ABCC5 0.47 8.0 0.4 2.11e-14 Anterior chamber depth; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg01074628 chr11:74204917 LIPT2 0.55 7.85 0.4 5.96e-14 Response to antipsychotic treatment; CRC cis rs2814982 0.514 rs73405691 chr6:34468767 A/G cg17674042 chr6:34482479 PACSIN1 -0.74 -8.65 -0.43 2.35e-16 Cholesterol, total;Total cholesterol levels; CRC cis rs3733585 0.699 rs6449159 chr4:9960498 G/A cg11266682 chr4:10021025 SLC2A9 -0.47 -9.67 -0.47 1.2e-19 Cleft plate (environmental tobacco smoke interaction); CRC cis rs10256972 0.516 rs12702081 chr7:1141528 T/C cg23978390 chr7:1156363 C7orf50 0.58 8.15 0.41 7.87e-15 Longevity;Endometriosis; CRC cis rs11212617 0.967 rs227061 chr11:108205329 A/G cg12106634 chr11:108092400 ATM;NPAT 0.43 6.34 0.33 7.77e-10 Response to metformin in type 2 diabetes (glycemic); CRC cis rs9399137 0.507 rs4896118 chr6:135276065 A/G cg22676075 chr6:135203613 NA -0.61 -9.2 -0.45 4.2e-18 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; CRC cis rs7607369 0.580 rs7568196 chr2:219652373 G/A cg02176678 chr2:219576539 TTLL4 -0.56 -8.7 -0.43 1.63e-16 Red blood cell count;Amyotrophic lateral sclerosis; CRC cis rs6681460 0.932 rs2483705 chr1:67191180 C/G cg02459107 chr1:67143332 SGIP1 -0.36 -6.31 -0.33 8.91e-10 Presence of antiphospholipid antibodies; CRC cis rs67311347 1.000 rs2276868 chr3:40498845 C/T cg09455208 chr3:40491958 NA -0.42 -8.87 -0.44 4.8e-17 Renal cell carcinoma; CRC cis rs2502731 0.539 rs3003615 chr9:130997892 C/T cg09976142 chr9:130955436 CIZ1 0.4 6.67 0.35 1.09e-10 Attention deficit hyperactivity disorder; CRC cis rs854765 0.929 rs854766 chr17:18012775 A/G cg16928487 chr17:17741425 SREBF1 -0.54 -9.52 -0.46 3.93e-19 Total body bone mineral density; CRC cis rs10504229 1.000 rs56350499 chr8:58178139 C/T cg24829409 chr8:58192753 C8orf71 -0.68 -11.34 -0.53 2.27e-25 Developmental language disorder (linguistic errors); CRC cis rs9858542 0.953 rs6446264 chr3:49417243 C/A cg07274523 chr3:49395745 GPX1 0.46 6.23 0.32 1.46e-9 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs932287 0.540 rs4910442 chr11:9044337 T/C cg21881798 chr11:8931708 C11orf17;ST5 0.59 8.67 0.43 1.94e-16 Colonoscopy-negative controls vs population controls; CRC cis rs2066819 1.000 rs11171803 chr12:56718422 T/C cg26714650 chr12:56694279 CS -1.39 -11.42 -0.53 1.14e-25 Psoriasis vulgaris; CRC cis rs7169223 0.653 rs3971703 chr15:79092481 G/C cg22753661 chr15:79092743 ADAMTS7 -0.46 -5.64 -0.3 3.64e-8 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; CRC cis rs7246657 0.943 rs10405407 chr19:37839164 C/T cg23950597 chr19:37808831 NA -0.47 -5.76 -0.3 1.94e-8 Coronary artery calcification; CRC cis rs6088813 1.000 rs4911492 chr20:33951799 G/A cg14752227 chr20:34000481 UQCC -0.37 -5.71 -0.3 2.49e-8 Height; CRC cis rs727479 0.502 rs28757202 chr15:51503881 T/A cg19946085 chr15:51559439 CYP19A1 -0.29 -5.83 -0.31 1.35e-8 Estradiol levels; CRC cis rs7618915 0.571 rs34115864 chr3:52612178 A/G cg05573699 chr3:52720067 GNL3;PBRM1 -0.44 -6.23 -0.32 1.44e-9 Bipolar disorder; CRC cis rs7223966 1.000 rs11542436 chr17:61778689 A/C cg23090583 chr17:61904693 PSMC5;FTSJ3 0.46 5.83 0.31 1.3e-8 Hip circumference adjusted for BMI;Body mass index; CRC cis rs2380220 0.606 rs4571572 chr6:96004823 T/C cg07718321 chr6:96025334 MANEA 0.43 5.65 0.3 3.4e-8 Behavioural disinhibition (generation interaction); CRC cis rs79387448 0.592 rs76362690 chr2:102951477 A/G cg09003973 chr2:102972529 NA 0.96 9.87 0.48 2.62e-20 Gut microbiota (bacterial taxa); CRC cis rs7786808 0.608 rs9692003 chr7:158204696 G/A cg15440763 chr7:158190612 PTPRN2 -0.41 -6.71 -0.35 8.4e-11 Obesity-related traits; CRC cis rs9929218 1.000 rs12446575 chr16:68791644 C/G cg02972257 chr16:68554789 NA 0.45 5.62 0.3 4.03e-8 Colorectal cancer; CRC cis rs7940866 0.770 rs10791104 chr11:130814893 A/T cg12179176 chr11:130786555 SNX19 0.65 9.36 0.46 1.26e-18 Schizophrenia; CRC cis rs7584330 0.554 rs76519914 chr2:238429818 G/A cg14458575 chr2:238380390 NA 0.57 7.47 0.38 7.48e-13 Prostate cancer; CRC trans rs10982213 0.830 rs2274163 chr9:117188714 C/T cg04314247 chr1:95286125 SLC44A3 0.37 6.24 0.33 1.37e-9 Interleukin-6 levels; CRC cis rs853679 0.550 rs1233701 chr6:28168726 C/G cg03623178 chr6:28175578 NA -1.01 -15.66 -0.65 1.09e-41 Depression; CRC cis rs6460942 0.915 rs2192842 chr7:12315752 C/G cg06484146 chr7:12443880 VWDE -0.6 -8.03 -0.4 1.76e-14 Coronary artery disease; CRC cis rs11190604 1.000 rs10883504 chr10:102280687 G/A cg07080220 chr10:102295463 HIF1AN 0.47 5.71 0.3 2.51e-8 Palmitoleic acid (16:1n-7) levels; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg05013783 chr12:56652058 ANKRD52 0.52 6.78 0.35 5.58e-11 Thyroid stimulating hormone; CRC cis rs3736485 0.966 rs12440990 chr15:51902259 G/A cg08986416 chr15:51914746 DMXL2 -0.46 -6.44 -0.33 4.36e-10 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs1552244 1.000 rs111392584 chr3:10075991 A/G cg16606324 chr3:10149918 C3orf24 0.73 9.77 0.47 5.73e-20 Alzheimer's disease; CRC trans rs12478296 0.786 rs72620862 chr2:243044787 T/C cg18288967 chr1:45987694 PRDX1 0.68 7.43 0.38 9.51e-13 Obesity-related traits; CRC trans rs11989744 0.500 rs7826966 chr8:23569106 G/T cg03492747 chr16:86543808 FOXF1 -0.58 -10.43 -0.5 3.2800000000000002e-22 Waist-hip ratio; CRC cis rs6502050 0.835 rs7502548 chr17:80087569 T/C cg13198984 chr17:80129470 CCDC57 -0.48 -8.58 -0.43 3.86e-16 Life satisfaction; CRC cis rs868943 0.714 rs4415182 chr6:116382811 G/A cg26893134 chr6:116381904 FRK 0.27 6.49 0.34 3.09e-10 Total cholesterol levels; CRC cis rs6502050 0.799 rs6416859 chr17:80111442 G/C cg09264619 chr17:80180166 NA -0.34 -5.81 -0.3 1.5e-8 Life satisfaction; CRC cis rs7917772 0.636 rs7894154 chr10:104524647 G/A cg04362960 chr10:104952993 NT5C2 0.46 6.18 0.32 1.85e-9 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC trans rs1005277 0.577 rs4934906 chr10:38015028 C/T cg23533926 chr12:111358616 MYL2 -0.41 -6.03 -0.32 4.45e-9 Extrinsic epigenetic age acceleration; CRC cis rs4713118 0.513 rs149942 chr6:28001610 T/C cg12172441 chr6:28176163 NA 0.52 7.34 0.38 1.64e-12 Parkinson's disease; CRC cis rs798554 0.959 rs798556 chr7:2759002 C/A cg04166393 chr7:2884313 GNA12 0.45 6.06 0.32 3.65e-9 Height; CRC cis rs9837602 1.000 rs13069311 chr3:99801628 A/C cg07805332 chr3:99536008 MIR548G;C3orf26 -0.47 -6.19 -0.32 1.74e-9 Breast cancer; CRC cis rs13108904 0.870 rs4493483 chr4:1279916 G/A cg21620606 chr4:1342894 KIAA1530 0.36 5.89 0.31 9.62e-9 Obesity-related traits; CRC trans rs61931739 0.534 rs11052979 chr12:34035774 G/T cg26384229 chr12:38710491 ALG10B 0.53 6.76 0.35 6.43e-11 Morning vs. evening chronotype; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg16933224 chr11:63604740 NA 0.41 6.01 0.31 5.06e-9 Response to antipsychotic treatment; CRC cis rs6694672 0.681 rs7554995 chr1:197148761 T/C cg13682187 chr1:196946512 CFHR5 0.5 7.53 0.38 4.98e-13 Asthma; CRC cis rs4555082 0.794 rs2735827 chr14:105710600 T/A cg06808227 chr14:105710500 BRF1 -0.62 -9.11 -0.45 7.99e-18 Mean platelet volume;Platelet distribution width; CRC cis rs561341 0.882 rs2521594 chr17:30302087 C/T cg00745463 chr17:30367425 LRRC37B -0.86 -9.47 -0.46 5.45e-19 Hip circumference adjusted for BMI; CRC cis rs6977940 0.512 rs6461600 chr7:2816537 C/T cg19731401 chr7:2775893 GNA12 0.48 5.91 0.31 8.52e-9 White matter integrity; CRC cis rs6952808 0.825 rs34296663 chr7:1935245 C/T cg04267008 chr7:1944627 MAD1L1 -0.83 -12.76 -0.58 1.38e-30 Bipolar disorder and schizophrenia; CRC cis rs7772486 0.875 rs2474353 chr6:146323883 G/A cg23711669 chr6:146136114 FBXO30 0.67 11.34 0.53 2.15e-25 Lobe attachment (rater-scored or self-reported); CRC cis rs12760731 0.920 rs12096233 chr1:178482882 A/G cg00404053 chr1:178313656 RASAL2 0.54 6.43 0.33 4.37e-10 Obesity-related traits; CRC cis rs9491140 0.539 rs10457447 chr6:124698568 A/C cg19267163 chr6:125004984 NKAIN2 -0.58 -6.91 -0.36 2.56e-11 Neuroticism; CRC cis rs9814567 1.000 rs4974483 chr3:134219001 A/G cg06541857 chr3:134203789 ANAPC13;CEP63 -0.38 -5.76 -0.3 1.95e-8 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs6952808 1.000 rs12540579 chr7:1882227 C/A cg02951883 chr7:2050386 MAD1L1 -0.68 -10.84 -0.51 1.27e-23 Bipolar disorder and schizophrenia; CRC cis rs4664293 0.647 rs357030 chr2:160493026 A/G cg08347373 chr2:160653686 CD302 -0.39 -6.68 -0.35 1.03e-10 Monocyte percentage of white cells; CRC cis rs6534441 0.727 rs6534444 chr4:125425867 A/G cg21609808 chr4:125404261 NA -0.41 -5.99 -0.31 5.44e-9 Major depressive disorder; CRC cis rs921968 0.541 rs7601872 chr2:219319885 C/G cg02176678 chr2:219576539 TTLL4 -0.57 -9.1 -0.45 8.86e-18 Mean corpuscular hemoglobin concentration; CRC cis rs720844 0.535 rs12997473 chr2:149284887 A/G cg09247360 chr2:149335327 NA -0.57 -5.85 -0.31 1.18e-8 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs4728302 0.869 rs6954712 chr7:133618853 G/A cg10665199 chr7:133106180 EXOC4 0.39 5.84 0.31 1.24e-8 Intelligence;Intelligence (multi-trait analysis); CRC cis rs7635838 0.892 rs9310383 chr3:11491305 A/G cg00170343 chr3:11313890 ATG7 -0.4 -6.1 -0.32 3.04e-9 HDL cholesterol; CRC cis rs67311347 1.000 rs73080137 chr3:40516412 A/G cg09455208 chr3:40491958 NA 0.47 9.44 0.46 7.24e-19 Renal cell carcinoma; CRC cis rs9910055 0.529 rs170637 chr17:42186868 C/T cg10896456 chr17:42255109 ASB16;C17orf65 -0.42 -6.58 -0.34 1.88e-10 Total body bone mineral density; CRC cis rs3820068 0.581 rs34453754 chr1:15993208 G/C cg24675056 chr1:15929824 NA 0.52 6.93 0.36 2.16e-11 Systolic blood pressure; CRC cis rs736408 0.688 rs2239551 chr3:52818579 A/G cg11645453 chr3:52864694 ITIH4 -0.38 -6.49 -0.34 3.24e-10 Bipolar disorder; CRC cis rs2213920 0.619 rs7857548 chr9:118199365 C/T cg13918206 chr9:118159781 DEC1 0.62 5.96 0.31 6.67e-9 Docetaxel-induced peripheral neuropathy in metastatic castrate-resistant prostate cancer; CRC cis rs12545109 0.800 rs1837617 chr8:57417592 C/T cg09654669 chr8:57350985 NA -0.41 -6.0 -0.31 5.28e-9 Obesity-related traits; CRC cis rs2408955 0.521 rs1476607 chr12:48524804 A/G cg15465823 chr12:48382534 COL2A1 -0.38 -6.14 -0.32 2.39e-9 Glycated hemoglobin levels; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg01213128 chr5:138629571 MATR3 -0.39 -6.18 -0.32 1.86e-9 Myopia (pathological); CRC cis rs9534288 0.699 rs1409433 chr13:46655501 T/C cg15192986 chr13:46630673 CPB2 -0.68 -8.69 -0.43 1.69e-16 Blood protein levels; CRC cis rs7772486 0.692 rs2265915 chr6:146194332 A/T cg13319975 chr6:146136371 FBXO30 -0.48 -7.27 -0.37 2.69e-12 Lobe attachment (rater-scored or self-reported); CRC cis rs11098499 0.754 rs7672778 chr4:120248585 A/G cg24375607 chr4:120327624 NA 0.48 7.61 0.39 2.87e-13 Corneal astigmatism; CRC cis rs9372498 0.536 rs9489407 chr6:118792337 A/T cg10217327 chr6:118973057 C6orf204 -0.49 -5.62 -0.3 4.07e-8 Diastolic blood pressure; CRC cis rs1862618 0.671 rs72644088 chr5:56241019 G/A cg18230493 chr5:56204884 C5orf35 0.58 8.63 0.43 2.72e-16 Initial pursuit acceleration; CRC cis rs1799949 0.965 rs4793230 chr17:41427403 A/C cg05368731 chr17:41323189 NBR1 0.59 8.73 0.43 1.29e-16 Menopause (age at onset); CRC cis rs10504229 0.728 rs72650858 chr8:58152832 G/A cg11062466 chr8:58055876 NA 0.45 6.11 0.32 2.74e-9 Developmental language disorder (linguistic errors); CRC cis rs9847710 0.967 rs2581824 chr3:53022408 A/C cg04503182 chr3:53078218 SFMBT1 -0.42 -6.35 -0.33 7.11e-10 Ulcerative colitis; CRC cis rs3741404 0.791 rs2282491 chr11:63918373 T/C cg05016508 chr11:63871570 FLRT1;MACROD1 0.43 6.48 0.34 3.31e-10 Platelet count; CRC cis rs7259376 0.902 rs11669179 chr19:22604729 C/G cg02657401 chr19:22469223 NA 0.3 6.54 0.34 2.3e-10 Menopause (age at onset); CRC cis rs1997103 1.000 rs4947504 chr7:55409428 T/C cg17469321 chr7:55412551 NA 0.72 11.1 0.52 1.6e-24 QRS interval (sulfonylurea treatment interaction); CRC trans rs9747201 0.926 rs7222764 chr17:80062698 G/A cg07393940 chr7:158741817 NA -0.52 -7.46 -0.38 7.77e-13 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs4700695 0.719 rs27080 chr5:65442271 A/G cg21114390 chr5:65439923 SFRS12 -0.64 -8.53 -0.43 5.25e-16 Facial morphology (factor 19); CRC cis rs55665837 0.559 rs11023209 chr11:14422600 T/C cg19336497 chr11:14380999 RRAS2 -0.44 -7.54 -0.38 4.75e-13 Vitamin D levels; CRC cis rs10504229 0.728 rs72650855 chr8:58152570 A/G cg02725872 chr8:58115012 NA -0.57 -9.07 -0.45 1.09e-17 Developmental language disorder (linguistic errors); CRC cis rs4713118 0.955 rs9380010 chr6:27683572 A/G cg12172441 chr6:28176163 NA 0.47 6.19 0.32 1.75e-9 Parkinson's disease; CRC cis rs2153535 0.580 rs1577472 chr6:8486215 G/A cg21535247 chr6:8435926 SLC35B3 0.49 7.38 0.38 1.3e-12 Motion sickness; CRC trans rs11039798 0.925 rs10769373 chr11:48531980 T/A cg03929089 chr4:120376271 NA 0.63 6.04 0.32 4.15e-9 Axial length; CRC cis rs4664293 0.867 rs7606046 chr2:160576158 A/G cg08347373 chr2:160653686 CD302 -0.46 -7.32 -0.37 1.95e-12 Monocyte percentage of white cells; CRC cis rs17711722 0.727 rs35850374 chr7:65357776 A/G cg18912574 chr7:65842487 NCRNA00174 0.33 5.66 0.3 3.37e-8 Calcium levels; CRC cis rs1707322 0.752 rs4586014 chr1:46150443 A/G cg06784218 chr1:46089804 CCDC17 0.65 12.22 0.56 1.4e-28 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs9303401 0.614 rs2333409 chr17:57139134 G/A cg10487724 chr17:56770010 TEX14;RAD51C 0.67 8.25 0.41 3.8e-15 Cognitive test performance; CRC cis rs4938330 0.608 rs2238006 chr11:117087792 A/C cg01368799 chr11:117014884 PAFAH1B2 -0.48 -6.14 -0.32 2.33e-9 Blood protein levels; CRC trans rs16984718 1.000 rs16984718 chr2:18509254 C/T cg08952239 chr16:85952285 IRF8 0.59 6.69 0.35 9.9e-11 Urate levels in obese individuals; CRC cis rs3760982 0.585 rs1386502 chr19:44293356 T/C cg12072164 chr19:44306565 LYPD5 0.36 5.68 0.3 3.04e-8 Breast cancer (estrogen-receptor negative);Breast cancer; CRC cis rs992157 0.835 rs2045434 chr2:219144498 A/G cg13835894 chr2:219148914 PNKD;TMBIM1 -0.35 -6.81 -0.35 4.66e-11 Colorectal cancer; CRC cis rs1062746 0.520 rs17770965 chr16:87328597 G/A cg02258303 chr16:87377426 FBXO31 -0.51 -7.32 -0.37 1.93e-12 Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 2 peripheral neuropathy); CRC cis rs6001027 0.540 rs1005529 chr22:38541266 T/C cg25457927 chr22:38595422 NA -0.3 -6.25 -0.33 1.24e-9 Melanoma; CRC cis rs853679 0.513 rs13437444 chr6:28070998 C/T cg03623178 chr6:28175578 NA 0.92 9.49 0.46 4.91e-19 Depression; CRC cis rs73206853 0.764 rs67828368 chr12:110546298 C/T cg12870014 chr12:110450643 ANKRD13A 0.79 9.26 0.45 2.68e-18 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg22822919 chr1:10270658 KIF1B 0.45 6.38 0.33 5.85e-10 Anxiety disorder; CRC cis rs801193 1.000 rs62466794 chr7:66191579 G/A cg11764359 chr7:65958608 NA 0.54 8.35 0.42 1.86e-15 Aortic root size; CRC trans rs1005277 0.563 rs2505215 chr10:38481273 A/G cg11292332 chr7:45801988 SEPT13 -0.38 -6.83 -0.35 4.14e-11 Extrinsic epigenetic age acceleration; CRC cis rs12477438 0.501 rs11692336 chr2:99740606 T/C cg14399236 chr2:99771627 LIPT1;TSGA10 0.73 12.08 0.55 4.6e-28 Chronic sinus infection; CRC cis rs4713118 0.621 rs9368548 chr6:28034737 A/G cg02683197 chr6:28174875 NA 0.72 8.8 0.44 7.84e-17 Parkinson's disease; CRC cis rs9303401 0.659 rs35539277 chr17:56853833 G/A cg02118635 chr17:56770003 RAD51C;TEX14 0.8 9.76 0.47 6.12e-20 Cognitive test performance; CRC cis rs279910 0.862 rs279899 chr9:965006 A/T cg13952963 chr9:998547 NA -0.37 -5.7 -0.3 2.68e-8 Exploratory eye movement dysfunction in schizophrenia (responsive search score); CRC cis rs1862618 0.853 rs1423621 chr5:56101035 G/T cg18230493 chr5:56204884 C5orf35 -0.71 -9.1 -0.45 8.93e-18 Initial pursuit acceleration; CRC cis rs4243830 0.850 rs12029123 chr1:6607142 C/T cg22792644 chr1:6614718 TAS1R1;NOL9 0.94 11.41 0.53 1.27e-25 Body mass index; CRC cis rs6426558 0.537 rs10799381 chr1:227239746 G/T cg10327440 chr1:227177885 CDC42BPA 0.46 6.82 0.35 4.48e-11 Neutrophil percentage of white cells; CRC trans rs2797160 0.967 rs2226158 chr6:125995467 C/T cg05039488 chr6:79577232 IRAK1BP1 -0.46 -6.72 -0.35 7.96e-11 Endometrial cancer; CRC cis rs9443645 0.810 rs9443637 chr6:79714708 C/T cg05283184 chr6:79620031 NA -0.55 -8.5 -0.42 6.61e-16 Intelligence (multi-trait analysis); CRC cis rs6840360 1.000 rs9995704 chr4:152619069 C/A cg09659197 chr4:152720779 NA 0.52 11.32 0.53 2.59e-25 Intelligence (multi-trait analysis); CRC cis rs9921222 0.521 rs78867928 chr16:368986 C/T cg26944245 chr16:421049 TMEM8A;MRPL28 0.44 5.76 0.3 1.94e-8 Bone mineral density (spine);Bone mineral density; CRC cis rs6952808 0.929 rs12699483 chr7:1975624 C/G cg02951883 chr7:2050386 MAD1L1 -0.71 -10.76 -0.51 2.51e-23 Bipolar disorder and schizophrenia; CRC cis rs9660992 0.736 rs55673946 chr1:205250475 T/C cg21643547 chr1:205240462 TMCC2 -0.47 -8.03 -0.4 1.79e-14 Mean corpuscular volume;Mean platelet volume; CRC cis rs7113874 0.589 rs10769908 chr11:8484089 A/G cg20771178 chr11:8615675 STK33 0.35 5.7 0.3 2.71e-8 Body mass index in physically active individuals;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs8062405 0.755 rs62034350 chr16:28562256 A/G cg05139728 chr16:28306816 SBK1 -0.37 -5.99 -0.31 5.4e-9 Cognitive ability (multi-trait analysis);Cognitive ability; CRC cis rs875971 0.638 rs6460305 chr7:66060408 G/A cg11764359 chr7:65958608 NA -0.55 -8.65 -0.43 2.34e-16 Aortic root size; CRC cis rs1005277 0.579 rs2505196 chr10:38393563 G/A cg00409905 chr10:38381863 ZNF37A -0.68 -11.32 -0.53 2.64e-25 Extrinsic epigenetic age acceleration; CRC trans rs2303319 0.504 rs961421 chr2:162626099 G/C cg23919916 chr10:103825097 HPS6 -0.69 -5.99 -0.31 5.54e-9 Cognitive function; CRC cis rs10504229 0.679 rs56040464 chr8:58131603 G/A cg05313129 chr8:58192883 C8orf71 -0.43 -6.11 -0.32 2.74e-9 Developmental language disorder (linguistic errors); CRC cis rs853679 0.517 rs4713150 chr6:28136212 G/A cg12273811 chr6:28175739 NA 0.73 9.13 0.45 7.14e-18 Depression; CRC cis rs1552244 1.000 rs35220123 chr3:10083169 C/T cg18598329 chr3:10140678 FANCD2;C3orf24 -0.89 -11.87 -0.55 2.69e-27 Alzheimer's disease; CRC cis rs4332037 0.510 rs58673065 chr7:1885600 A/G cg25834613 chr7:1915315 MAD1L1 -0.37 -6.34 -0.33 7.44e-10 Bipolar disorder; CRC cis rs1552172 0.881 rs1471634 chr1:145702115 A/G cg11743829 chr1:145714124 CD160 0.41 6.29 0.33 1.04e-9 Breast cancer; CRC cis rs896854 0.818 rs896855 chr8:95959808 A/G cg09323728 chr8:95962352 TP53INP1 -0.42 -6.95 -0.36 1.96e-11 Type 2 diabetes; CRC cis rs56307353 0.513 rs2041120 chr19:1961474 C/T cg02376178 chr19:1969988 CSNK1G2 0.73 12.21 0.56 1.53e-28 Coronary artery disease; CRC cis rs6952808 0.689 rs2008263 chr7:2048335 A/G cg21782813 chr7:2030301 MAD1L1 0.53 9.36 0.46 1.3e-18 Bipolar disorder and schizophrenia; CRC cis rs6952808 0.792 rs2056478 chr7:1953897 C/T cg04267008 chr7:1944627 MAD1L1 -0.84 -12.71 -0.57 2.2e-30 Bipolar disorder and schizophrenia; CRC cis rs4664293 0.647 rs1425042 chr2:160440515 G/A cg08347373 chr2:160653686 CD302 -0.38 -6.48 -0.34 3.42e-10 Monocyte percentage of white cells; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg23069444 chr2:85839322 C2orf68 -0.42 -6.5 -0.34 3.06e-10 Liver disease severity in Alagille syndrome; CRC cis rs9487051 0.714 rs6927569 chr6:109621494 T/C cg12927641 chr6:109611667 NA -0.36 -6.41 -0.33 5.13e-10 Reticulocyte fraction of red cells; CRC cis rs7786877 0.723 rs11764045 chr7:100212754 C/T cg16850897 chr7:100343110 ZAN -0.54 -6.62 -0.34 1.44e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs1577917 1.000 rs12192992 chr6:86609915 A/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.52 -6.47 -0.34 3.52e-10 Response to antipsychotic treatment; CRC cis rs10504229 1.000 rs76944716 chr8:58191643 T/C cg01721255 chr8:58191610 C8orf71 0.5 6.06 0.32 3.65e-9 Developmental language disorder (linguistic errors); CRC cis rs9768139 0.935 rs6953748 chr7:158121184 G/A cg06219351 chr7:158114137 PTPRN2 0.44 6.56 0.34 2.03e-10 Calcium levels; CRC cis rs853679 0.517 rs9380060 chr6:28132603 G/A cg12172441 chr6:28176163 NA 0.64 7.53 0.38 5.03e-13 Depression; CRC cis rs728616 0.867 rs34870056 chr10:81948055 G/A cg11900509 chr10:81946545 ANXA11 -0.67 -6.83 -0.35 4.06e-11 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs875971 0.545 rs12673308 chr7:65631361 C/A cg02869306 chr7:64672164 INTS4L1 -0.43 -6.18 -0.32 1.86e-9 Aortic root size; CRC cis rs12681287 0.517 rs34367154 chr8:87508749 A/T cg27223183 chr8:87520930 FAM82B -0.52 -7.37 -0.38 1.38e-12 Caudate activity during reward; CRC cis rs9916302 0.904 rs2168785 chr17:37407135 C/T cg07936489 chr17:37558343 FBXL20 -0.81 -12.45 -0.57 2.04e-29 Glomerular filtration rate (creatinine); CRC cis rs7954584 0.531 rs11043271 chr12:122394921 A/C cg21171335 chr12:122356390 WDR66 0.41 6.23 0.32 1.4e-9 Mean corpuscular volume; CRC cis rs9467711 0.591 rs3734523 chr6:25925987 G/A cg08501292 chr6:25962987 TRIM38 0.95 9.32 0.46 1.72e-18 Autism spectrum disorder or schizophrenia; CRC cis rs9733 0.650 rs11204680 chr1:150587140 T/G cg17724175 chr1:150552817 MCL1 -0.51 -8.08 -0.41 1.27e-14 Tonsillectomy; CRC cis rs763121 0.776 rs4820346 chr22:39125074 C/G cg06022373 chr22:39101656 GTPBP1 -0.73 -11.04 -0.52 2.67e-24 Menopause (age at onset); CRC cis rs11098499 0.863 rs3775845 chr4:120432447 T/C cg24375607 chr4:120327624 NA 0.47 7.17 0.37 5.06e-12 Corneal astigmatism; CRC cis rs3087591 1.000 rs2905884 chr17:29512476 A/G cg24425628 chr17:29625626 OMG;NF1 0.85 16.17 0.67 1.04e-43 Hip circumference; CRC cis rs9556958 0.588 rs9556964 chr13:99159306 T/C cg15168958 chr13:99100528 FARP1 0.37 5.64 0.3 3.73e-8 Educational attainment (years of education); CRC trans rs2303319 0.504 rs12470743 chr2:162611202 G/A cg22677401 chr17:46026860 NA -0.67 -6.07 -0.32 3.57e-9 Cognitive function; CRC cis rs7666738 0.830 rs10014284 chr4:98681951 G/C cg17366294 chr4:99064904 C4orf37 0.35 5.7 0.3 2.66e-8 Colonoscopy-negative controls vs population controls; CRC cis rs1005277 0.579 rs2474563 chr10:38375938 T/C cg25517755 chr10:38738941 LOC399744 -0.44 -6.42 -0.33 4.86e-10 Extrinsic epigenetic age acceleration; CRC cis rs7224685 0.501 rs4790171 chr17:4022899 T/C cg10724054 chr17:3904396 NA 0.47 7.6 0.39 3.05e-13 Type 2 diabetes; CRC cis rs6922632 1.000 rs6922632 chr6:24107093 C/A cg26194775 chr6:24126114 NRSN1 -0.62 -7.07 -0.36 9.42e-12 Information processing speed; CRC cis rs9354308 0.933 rs2802062 chr6:66561973 C/G cg07460842 chr6:66804631 NA 0.47 5.9 0.31 9.09e-9 Metabolite levels; CRC cis rs7635838 0.859 rs6784883 chr3:11444453 G/A cg00170343 chr3:11313890 ATG7 0.42 6.35 0.33 7.36e-10 HDL cholesterol; CRC cis rs28386778 0.897 rs2665796 chr17:61923716 G/C cg23090583 chr17:61904693 PSMC5;FTSJ3 1.03 20.18 0.74 1.67e-59 Prudent dietary pattern; CRC cis rs713587 0.967 rs6752378 chr2:25150116 C/A cg22495460 chr2:25135724 ADCY3 -0.8 -14.66 -0.63 8.74e-38 Body mass index in non-asthmatics; CRC cis rs1348850 0.554 rs11679519 chr2:178432110 C/T cg27490568 chr2:178487706 NA 0.5 6.35 0.33 7.17e-10 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs11166629 1.000 rs894349 chr8:135638055 T/C cg27224718 chr8:135614730 ZFAT 0.51 7.6 0.39 3.18e-13 Smoking quantity; CRC cis rs9486719 1.000 rs12530462 chr6:97053514 C/T cg06623918 chr6:96969491 KIAA0776 -0.81 -9.59 -0.47 2.24e-19 Migraine;Coronary artery disease; CRC cis rs62064224 0.589 rs756785 chr17:30812845 T/C cg09324608 chr17:30823087 MYO1D 0.34 5.93 0.31 7.52e-9 Schizophrenia; CRC cis rs9902453 0.933 rs60694493 chr17:28473256 A/G cg26525008 chr17:28256777 EFCAB5;SSH2 0.55 8.37 0.42 1.7e-15 Coffee consumption (cups per day); CRC cis rs7618501 0.722 rs9853458 chr3:49783211 A/C cg24308560 chr3:49941425 MST1R 0.45 7.01 0.36 1.32e-11 Intelligence (multi-trait analysis); CRC cis rs2617583 0.530 rs1478435 chr5:1454612 T/C cg07148919 chr5:1466943 LPCAT1 -0.46 -5.93 -0.31 7.79e-9 Breast cancer; CRC cis rs9443645 0.509 rs12176511 chr6:79565721 G/A cg05283184 chr6:79620031 NA 0.45 6.59 0.34 1.75e-10 Intelligence (multi-trait analysis); CRC cis rs17376456 0.569 rs17083377 chr5:93164870 C/G cg09848695 chr5:92956644 FAM172A;MIR2277 0.49 5.85 0.31 1.2e-8 Diabetic retinopathy; CRC cis rs12024301 0.557 rs79534455 chr1:183623626 G/A cg11505048 chr1:183622726 RGL1;APOBEC4 0.78 6.91 0.36 2.49e-11 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs28386778 0.897 rs57108948 chr17:61802378 T/C cg06873352 chr17:61820015 STRADA 0.79 14.79 0.63 2.66e-38 Prudent dietary pattern; CRC trans rs1864585 0.520 rs73208782 chr8:10677555 G/A cg26278703 chr11:58910052 FAM111A 0.56 6.47 0.34 3.51e-10 Neutrophil percentage of white cells;Lymphocyte percentage of white cells; CRC cis rs11098499 0.863 rs12498539 chr4:120468370 C/T cg24375607 chr4:120327624 NA 0.48 7.49 0.38 6.38e-13 Corneal astigmatism; CRC cis rs9814567 0.806 rs7648616 chr3:134318074 C/T cg06109529 chr3:134205091 CEP63;ANAPC13 -0.68 -10.11 -0.49 4.15e-21 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs6598955 0.543 rs57564009 chr1:26557618 A/T cg04990556 chr1:26633338 UBXN11 0.85 10.44 0.5 3.2e-22 Obesity-related traits; CRC cis rs6502050 0.871 rs8080366 chr17:80067298 A/G cg13198984 chr17:80129470 CCDC57 -0.47 -7.99 -0.4 2.37e-14 Life satisfaction; CRC cis rs9916302 0.904 rs4795359 chr17:37573146 C/T cg07936489 chr17:37558343 FBXL20 -0.83 -13.1 -0.59 7.34e-32 Glomerular filtration rate (creatinine); CRC cis rs9905704 0.846 rs304262 chr17:56814456 A/G cg12560992 chr17:57184187 TRIM37 0.55 7.95 0.4 3e-14 Testicular germ cell tumor; CRC trans rs7618501 1.000 rs4855867 chr3:49745822 C/T cg21582582 chr3:182698605 DCUN1D1 -0.56 -8.25 -0.41 3.82e-15 Intelligence (multi-trait analysis); CRC cis rs9925964 0.900 rs9934438 chr16:31104878 G/A cg03418659 chr16:31128414 MYST1 0.47 6.75 0.35 6.72e-11 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs12791968 1.000 rs1552301 chr11:45002551 A/G cg11846598 chr11:44996168 LOC221122 -0.71 -12.42 -0.57 2.59e-29 Inhibitory control; CRC cis rs9457247 1.000 rs2149091 chr6:167372786 C/T cg23791538 chr6:167370224 RNASET2 0.39 6.1 0.32 2.93e-9 Crohn's disease; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg02709261 chr1:179051893 TOR3A 0.45 6.13 0.32 2.5e-9 Response to antipsychotic treatment; CRC cis rs747650 0.504 rs10838652 chr11:47077837 C/T cg19486271 chr11:47235900 DDB2 -0.44 -5.86 -0.31 1.11e-8 Acne (severe); CRC cis rs8060686 0.858 rs7199443 chr16:67841129 T/G cg07125278 chr16:67683757 RLTPR -0.46 -6.22 -0.32 1.51e-9 HDL cholesterol;Metabolic syndrome; CRC cis rs965469 0.895 rs6037592 chr20:3392950 T/G cg25506879 chr20:3388711 C20orf194 -0.42 -6.3 -0.33 9.7e-10 IFN-related cytopenia; CRC cis rs7412746 0.658 rs4970988 chr1:150950062 A/G cg15448220 chr1:150897856 SETDB1 -0.52 -7.34 -0.38 1.65e-12 Melanoma; CRC cis rs7731657 0.537 rs10073388 chr5:130188080 C/T cg08523029 chr5:130500466 HINT1 -0.45 -5.92 -0.31 8.17e-9 Fasting plasma glucose; CRC trans rs7267979 0.816 rs404775 chr20:25481117 A/G cg17903999 chr18:56338584 MALT1 -0.4 -6.54 -0.34 2.3e-10 Liver enzyme levels (alkaline phosphatase); CRC cis rs853679 0.517 rs9393893 chr6:28109262 T/C cg18032046 chr6:28092343 ZSCAN16 -0.51 -5.93 -0.31 7.47e-9 Depression; CRC cis rs4400599 0.618 rs10908751 chr1:154187305 C/T cg26808167 chr1:154192205 UBAP2L;C1orf43 -0.37 -5.65 -0.3 3.48e-8 Platelet distribution width; CRC cis rs6586163 0.934 rs7897395 chr10:90754607 T/C cg03111039 chr10:90751583 FAS;ACTA2 -0.5 -7.33 -0.37 1.74e-12 Chronic lymphocytic leukemia; CRC cis rs9325144 0.600 rs12227663 chr12:38734922 C/T cg26384229 chr12:38710491 ALG10B -0.56 -8.28 -0.42 3.19e-15 Morning vs. evening chronotype; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg15604425 chr10:103825102 HPS6 0.42 6.16 0.32 2.16e-9 Intelligence (multi-trait analysis); CRC cis rs6456156 0.565 rs12529959 chr6:167469292 T/C cg07741184 chr6:167504864 NA 0.39 6.85 0.35 3.66e-11 Primary biliary cholangitis; CRC cis rs12024301 0.557 rs16861254 chr1:183592275 T/C cg11505048 chr1:183622726 RGL1;APOBEC4 0.76 6.93 0.36 2.16e-11 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs1832871 0.711 rs9459918 chr6:158703604 A/C cg07165851 chr6:158734300 TULP4 0.61 7.67 0.39 1.92e-13 Height; CRC cis rs873946 0.586 rs57431984 chr10:134567697 C/T cg26818010 chr10:134567672 INPP5A -0.71 -9.2 -0.45 4.39e-18 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CRC cis rs6496667 0.865 rs62019305 chr15:90887765 A/T cg04176472 chr15:90893244 GABARAPL3 0.58 6.84 0.35 3.94e-11 Rheumatoid arthritis; CRC cis rs4237845 0.537 rs12426201 chr12:58259752 C/T cg02175503 chr12:58329896 NA 0.46 5.67 0.3 3.09e-8 Intelligence (multi-trait analysis); CRC cis rs9309711 0.666 rs11127429 chr2:3485224 T/G cg15506890 chr2:3487001 NA -0.53 -8.58 -0.43 3.92e-16 Neurofibrillary tangles; CRC cis rs7178572 0.625 rs12904553 chr15:77845959 G/A cg22256960 chr15:77711686 NA -0.54 -8.24 -0.41 4.17e-15 Type 2 diabetes; CRC trans rs1455244 0.700 rs7229302 chr18:11508904 G/T cg19626500 chr19:17445531 ANO8 0.37 5.99 0.31 5.47e-9 Schizophrenia; CRC cis rs17270561 0.609 rs9356986 chr6:25739119 T/C cg16482183 chr6:26056742 HIST1H1C 0.83 10.58 0.5 1.07e-22 Iron status biomarkers; CRC cis rs9372498 0.536 rs9489399 chr6:118767147 C/A cg24463073 chr6:118973353 C6orf204 0.51 6.81 0.35 4.71e-11 Diastolic blood pressure; CRC cis rs3796352 0.764 rs34872575 chr3:52986277 G/A cg06204229 chr3:52865917 ITIH4 0.5 5.7 0.3 2.67e-8 Immune reponse to smallpox (secreted IL-2); CRC cis rs4862750 0.872 rs7672831 chr4:187898882 C/T cg06074448 chr4:187884817 NA -0.59 -11.26 -0.53 4.41e-25 Lobe attachment (rater-scored or self-reported); CRC cis rs10751667 0.666 rs10794347 chr11:939863 G/A cg01483505 chr11:975446 AP2A2 0.44 7.24 0.37 3.16e-12 Alzheimer's disease (late onset); CRC cis rs6502050 0.731 rs35156322 chr17:80096323 T/C cg09264619 chr17:80180166 NA -0.34 -5.81 -0.3 1.5e-8 Life satisfaction; CRC cis rs427941 0.703 rs201453 chr7:101739788 T/C cg06246474 chr7:101738831 CUX1 0.46 7.23 0.37 3.35e-12 Plasma omega-3 polyunsaturated fatty acid level (eicosapentaenoic acid); CRC trans rs1814175 0.534 rs1983448 chr11:49933856 C/A cg15704280 chr7:45808275 SEPT13 -0.95 -16.42 -0.67 1.09e-44 Height; CRC cis rs10971721 0.731 rs10971750 chr9:33869781 T/C cg13495928 chr9:33750294 PRSS3 0.56 5.95 0.31 6.96e-9 Body mass index; CRC cis rs7617773 0.817 rs936427 chr3:48301074 A/G cg11946769 chr3:48343235 NME6 -0.71 -9.21 -0.45 3.82e-18 Coronary artery disease; CRC cis rs1129187 0.967 rs3805951 chr6:42937176 C/A cg03790207 chr6:42947109 PEX6 -0.44 -6.18 -0.32 1.92e-9 Alzheimer's disease in APOE e4+ carriers; CRC trans rs57221529 0.766 rs72706606 chr5:558609 T/C cg11887960 chr12:57824829 NA 0.58 6.44 0.33 4.17e-10 Lung disease severity in cystic fibrosis; CRC cis rs6582630 0.638 rs12425379 chr12:38523705 G/A cg26384229 chr12:38710491 ALG10B -0.52 -7.59 -0.39 3.38e-13 Drug-induced liver injury (flucloxacillin); CRC cis rs67981189 0.529 rs17093738 chr14:71586648 C/T cg15910301 chr14:71632612 NA 0.3 6.0 0.31 5.24e-9 Schizophrenia; CRC cis rs2281845 0.791 rs1325313 chr1:201076167 C/T cg22815214 chr1:201083145 CACNA1S 0.58 9.36 0.46 1.28e-18 Permanent tooth development; CRC cis rs7666738 0.830 rs17027225 chr4:99028564 C/T cg17366294 chr4:99064904 C4orf37 0.44 7.48 0.38 6.96e-13 Colonoscopy-negative controls vs population controls; CRC cis rs10876993 0.680 rs2277322 chr12:58009202 T/C cg15848620 chr12:58087721 OS9 0.6 8.14 0.41 8.12e-15 Celiac disease or Rheumatoid arthritis; CRC cis rs3823572 0.564 rs2953624 chr7:133659125 C/G cg03336402 chr7:133662267 EXOC4 -0.69 -10.79 -0.51 1.99e-23 Intelligence (multi-trait analysis); CRC cis rs10504229 1.000 rs67105789 chr8:58192002 G/T cg02725872 chr8:58115012 NA -0.38 -6.43 -0.33 4.44e-10 Developmental language disorder (linguistic errors); CRC cis rs8077889 0.917 rs72836545 chr17:41892602 A/G cg25876840 chr17:41920477 NA 0.6 8.38 0.42 1.56e-15 Triglycerides; CRC trans rs1814175 0.935 rs28586931 chr11:49693872 G/A cg11707556 chr5:10655725 ANKRD33B -0.43 -8.02 -0.4 1.85e-14 Height; CRC cis rs72781680 0.716 rs78332127 chr2:24150163 C/G cg08917208 chr2:24149416 ATAD2B 0.55 6.68 0.35 1.03e-10 Lymphocyte counts; CRC cis rs7927771 0.864 rs755553 chr11:47432303 G/A cg05585544 chr11:47624801 NA 0.47 8.48 0.42 7.86e-16 Subjective well-being; CRC cis rs9487051 1.000 rs9386796 chr6:109618704 C/T cg21918786 chr6:109611834 NA -0.38 -6.47 -0.34 3.52e-10 Reticulocyte fraction of red cells; CRC cis rs28386778 0.830 rs2584625 chr17:61903445 G/C cg22520471 chr17:61851767 DDX42;CCDC47 0.76 11.71 0.54 1.01e-26 Prudent dietary pattern; CRC cis rs7487075 0.786 rs4768696 chr12:46726376 G/A cg22049899 chr12:47219821 SLC38A4 0.33 6.19 0.32 1.83e-9 Itch intensity from mosquito bite; CRC cis rs7216064 1.000 rs7223813 chr17:65945840 A/G cg12091567 chr17:66097778 LOC651250 -0.62 -7.31 -0.37 2e-12 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CRC cis rs7829975 0.846 rs6601724 chr8:8544872 C/T cg08975724 chr8:8085496 FLJ10661 -0.37 -5.85 -0.31 1.19e-8 Mood instability; CRC trans rs61931739 0.517 rs10772139 chr12:34186178 A/T cg26384229 chr12:38710491 ALG10B 0.54 6.88 0.35 2.99e-11 Morning vs. evening chronotype; CRC cis rs10464366 0.957 rs6979210 chr7:39104119 C/G cg15212455 chr7:39170539 POU6F2 0.45 5.69 0.3 2.82e-8 IgG glycosylation; CRC cis rs911119 0.913 rs6036465 chr20:23588003 G/T cg16589663 chr20:23618590 CST3 0.42 6.17 0.32 1.95e-9 Chronic kidney disease; CRC cis rs9549328 0.642 rs2993343 chr13:113616844 C/G cg24588162 chr13:113633484 MCF2L 0.36 6.36 0.33 6.63e-10 Systolic blood pressure; CRC cis rs6724607 0.875 rs9630991 chr2:191432139 G/A cg27211696 chr2:191398769 TMEM194B 0.4 5.94 0.31 7.25e-9 Pulse pressure; CRC cis rs873946 0.586 rs12782567 chr10:134576709 C/G cg18305652 chr10:134549665 INPP5A -0.45 -5.69 -0.3 2.75e-8 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CRC cis rs910316 0.737 rs175077 chr14:75506875 G/A cg03030879 chr14:75389066 RPS6KL1 0.41 6.18 0.32 1.84e-9 Height; CRC cis rs9926296 0.581 rs6500457 chr16:89898764 C/G cg27121462 chr16:89883253 FANCA -0.43 -6.52 -0.34 2.65e-10 Vitiligo; CRC cis rs763121 0.819 rs5757237 chr22:39073835 G/C cg06544989 chr22:39130855 UNC84B 0.46 7.04 0.36 1.09e-11 Menopause (age at onset); CRC cis rs13191362 0.935 rs67889271 chr6:163045753 T/G cg06582575 chr6:163149167 PACRG;PARK2 0.91 11.12 0.52 1.33e-24 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs7727544 0.507 rs10051679 chr5:131570931 T/A cg18301423 chr5:131593218 PDLIM4 0.42 7.63 0.39 2.62e-13 Blood metabolite levels; CRC cis rs644799 0.623 rs17207890 chr11:95490754 C/T cg25622487 chr11:95524042 FAM76B;CEP57 0.56 7.67 0.39 1.97e-13 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs11098499 0.562 rs58583086 chr4:120556362 A/G cg09307838 chr4:120376055 NA -0.58 -9.1 -0.45 8.74e-18 Corneal astigmatism; CRC cis rs34779708 0.931 rs34087268 chr10:35346724 T/G cg03585969 chr10:35415529 CREM 0.67 8.91 0.44 3.47e-17 Inflammatory bowel disease;Crohn's disease; CRC cis rs3091242 0.967 rs1053438 chr1:25687901 T/C cg23205692 chr1:25664452 TMEM50A -0.39 -5.66 -0.3 3.39e-8 Erythrocyte sedimentation rate; CRC cis rs427941 0.632 rs201509 chr7:101765002 C/T cg06246474 chr7:101738831 CUX1 0.45 6.86 0.35 3.36e-11 Plasma omega-3 polyunsaturated fatty acid level (eicosapentaenoic acid); CRC cis rs10751667 0.621 rs7396107 chr11:970029 C/T ch.11.42038R chr11:967971 AP2A2 0.58 9.98 0.48 1.16e-20 Alzheimer's disease (late onset); CRC cis rs7394190 0.748 rs11000773 chr10:75534115 G/T cg07699608 chr10:75541558 CHCHD1 0.61 6.37 0.33 6.53e-10 Incident atrial fibrillation; CRC cis rs902774 0.530 rs11834907 chr12:53350985 C/T cg16329197 chr12:53359506 NA -1.05 -10.08 -0.49 5.41e-21 Prostate cancer; CRC cis rs13108904 0.901 rs12509700 chr4:1296321 A/G cg02018176 chr4:1364513 KIAA1530 0.38 6.46 0.34 3.68e-10 Obesity-related traits; CRC cis rs7618501 0.633 rs9866695 chr3:50069452 G/T cg05623727 chr3:50126028 RBM5 -0.45 -7.57 -0.39 3.74e-13 Intelligence (multi-trait analysis); CRC cis rs780096 0.587 rs10205219 chr2:27568565 T/C cg27432699 chr2:27873401 GPN1 -0.48 -7.34 -0.38 1.7e-12 Total body bone mineral density; CRC cis rs6662572 0.737 rs10890357 chr1:46318054 T/G cg03123370 chr1:45965343 CCDC163P;MMACHC -0.46 -5.9 -0.31 8.93e-9 Blood protein levels; CRC cis rs8077889 0.917 rs8081646 chr17:41893360 T/C cg25876840 chr17:41920477 NA 0.53 7.65 0.39 2.23e-13 Triglycerides; CRC cis rs780096 0.526 rs780112 chr2:27665361 C/G cg12648201 chr2:27665141 KRTCAP3 -0.32 -6.33 -0.33 8.21e-10 Total body bone mineral density; CRC cis rs910316 0.967 rs119076 chr14:75572419 G/T cg03030879 chr14:75389066 RPS6KL1 0.43 6.8 0.35 4.94e-11 Height; CRC cis rs2836974 0.965 rs8131126 chr21:40655754 A/G cg17971929 chr21:40555470 PSMG1 0.74 10.15 0.49 3.2e-21 Cognitive function; CRC cis rs6893807 1.000 rs2304608 chr5:87962298 C/A cg09002922 chr5:87956389 LOC645323 -0.44 -6.2 -0.32 1.72e-9 Body mass index; CRC cis rs3768617 0.565 rs2027080 chr1:183074415 C/T ch.1.3577855R chr1:183094577 LAMC1 0.89 15.72 0.65 6.5e-42 Fuchs's corneal dystrophy; CRC cis rs7605827 0.930 rs6431704 chr2:15592061 G/T cg19274914 chr2:15703543 NA 0.4 6.04 0.32 4.18e-9 Educational attainment (years of education); CRC cis rs4713118 0.699 rs200978 chr6:27853168 C/G cg02683197 chr6:28174875 NA 0.72 9.05 0.45 1.31e-17 Parkinson's disease; CRC cis rs28386778 0.897 rs2859619 chr17:61917686 T/C cg23090583 chr17:61904693 PSMC5;FTSJ3 1.05 20.14 0.74 2.41e-59 Prudent dietary pattern; CRC cis rs1799949 1.000 rs8176212 chr17:41226601 G/C cg25072359 chr17:41440525 NA 0.46 6.93 0.36 2.19e-11 Menopause (age at onset); CRC cis rs7726839 0.507 rs72703100 chr5:614291 C/T cg09021430 chr5:549028 NA -0.73 -8.35 -0.42 1.94e-15 Obesity-related traits; CRC cis rs514406 0.893 rs1242330 chr1:53396842 T/G cg27535305 chr1:53392650 SCP2 -0.4 -7.17 -0.37 4.9e-12 Monocyte count; CRC cis rs7927771 0.832 rs55677087 chr11:47397714 C/G cg05585544 chr11:47624801 NA -0.53 -9.38 -0.46 1.15e-18 Subjective well-being; CRC cis rs992157 0.698 rs6746089 chr2:219170377 A/G cg13835894 chr2:219148914 PNKD;TMBIM1 0.32 6.17 0.32 1.98e-9 Colorectal cancer; CRC cis rs736801 0.808 rs2706396 chr5:131796809 A/C cg02033258 chr5:131593261 PDLIM4 -0.34 -6.12 -0.32 2.59e-9 Breast cancer;Mosquito bite size; CRC cis rs1712517 0.844 rs4918003 chr10:105044157 C/T cg05636881 chr10:105038444 INA 0.47 8.09 0.41 1.16e-14 Migraine; CRC trans rs16846053 0.786 rs72873645 chr2:162495047 G/A cg06896663 chr8:82754093 SNX16 -0.68 -6.1 -0.32 3.01e-9 Blood osmolality (transformed sodium); CRC cis rs796364 0.865 rs769948 chr2:200728475 C/A cg25936922 chr2:200820526 C2orf60;C2orf47 0.7 7.82 0.4 7.23e-14 Schizophrenia; CRC trans rs2470578 0.716 rs2733514 chr3:17323931 A/G cg01086389 chr3:150321178 SELT -0.42 -6.09 -0.32 3.24e-9 Schizophrenia; CRC cis rs9420 0.884 rs644883 chr11:57663522 C/G cg23127183 chr11:57508653 C11orf31 0.47 6.41 0.33 5.04e-10 Schizophrenia; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg21989094 chr19:39421295 MRPS12;SARS2 0.43 6.25 0.33 1.27e-9 Response to antipsychotic treatment; CRC cis rs172166 0.694 rs2791332 chr6:28108788 C/T cg15845792 chr6:28175446 NA 0.79 11.65 0.54 1.66e-26 Cardiac Troponin-T levels; CRC cis rs9747201 0.962 rs6502062 chr17:80086177 T/G cg09264619 chr17:80180166 NA 0.52 7.54 0.38 4.48e-13 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs2204008 0.692 rs11613378 chr12:38213138 T/A cg26384229 chr12:38710491 ALG10B 0.69 9.26 0.45 2.81e-18 Bladder cancer; CRC cis rs7264396 0.563 rs17092980 chr20:34289005 T/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.49 -6.97 -0.36 1.7e-11 Total cholesterol levels; CRC cis rs6570726 0.818 rs9399555 chr6:145877554 T/C cg13319975 chr6:146136371 FBXO30 -0.43 -6.39 -0.33 5.79e-10 Lobe attachment (rater-scored or self-reported); CRC cis rs1018836 0.828 rs4734250 chr8:91591239 C/G cg16814680 chr8:91681699 NA 0.64 10.34 0.5 7.07e-22 Ejection fraction in Tripanosoma cruzi seropositivity; CRC trans rs1814175 0.817 rs11040651 chr11:49938395 G/A cg15704280 chr7:45808275 SEPT13 -0.97 -18.78 -0.72 5.61e-54 Height; CRC cis rs6502050 0.805 rs7406682 chr17:80084368 C/T cg13198984 chr17:80129470 CCDC57 -0.48 -8.56 -0.43 4.49e-16 Life satisfaction; CRC cis rs7927771 0.832 rs896816 chr11:47394338 T/C cg18512352 chr11:47633146 NA 0.34 6.55 0.34 2.28e-10 Subjective well-being; CRC cis rs7772486 0.875 rs6938972 chr6:146410608 G/A cg13319975 chr6:146136371 FBXO30 -0.4 -6.1 -0.32 2.94e-9 Lobe attachment (rater-scored or self-reported); CRC trans rs1997103 1.000 rs4948011 chr7:55403859 A/G cg20935933 chr6:143382018 AIG1 0.45 6.12 0.32 2.65e-9 QRS interval (sulfonylurea treatment interaction); CRC trans rs13046373 0.905 rs4816372 chr21:32077414 A/T cg03244796 chr16:84163961 HSDL1 -0.38 -6.17 -0.32 1.96e-9 HDL cholesterol; CRC cis rs854765 0.547 rs4368210 chr17:17896090 A/G cg04398451 chr17:18023971 MYO15A 0.64 11.67 0.54 1.42e-26 Total body bone mineral density; CRC cis rs644148 0.738 rs2686767 chr19:44995037 G/C cg15540054 chr19:45004280 ZNF180 -0.41 -5.74 -0.3 2.14e-8 Personality dimensions; CRC cis rs1572438 0.896 rs9405366 chr6:858296 A/C cg21062780 chr6:887772 NA -0.49 -7.19 -0.37 4.52e-12 Aging; CRC cis rs6456156 0.846 rs9364891 chr6:167516319 C/T cg07513332 chr6:167530253 CCR6 -0.41 -7.35 -0.38 1.62e-12 Primary biliary cholangitis; CRC cis rs12497850 0.931 rs9311430 chr3:48845251 C/T cg07636037 chr3:49044803 WDR6 1.04 18.72 0.72 9.87e-54 Parkinson's disease; CRC cis rs904251 0.504 rs9380677 chr6:37480366 A/G cg25019722 chr6:37503610 NA -0.43 -7.8 -0.39 8.48e-14 Cognitive performance; CRC cis rs2033711 0.840 rs3764533 chr19:58929194 A/G cg13877915 chr19:58951672 ZNF132 0.44 7.08 0.36 8.92e-12 Uric acid clearance; CRC cis rs9522267 0.535 rs2039915 chr13:112238794 C/T cg26182253 chr13:112236782 NA 0.31 6.24 0.33 1.33e-9 Hepatitis; CRC cis rs6540559 0.673 rs17015218 chr1:209967915 A/G cg22029157 chr1:209979665 IRF6 0.73 9.59 0.47 2.2e-19 Cleft lip with or without cleft palate; CRC cis rs10504229 0.775 rs17216236 chr8:58159352 G/A cg02290350 chr8:58132656 NA -0.51 -6.4 -0.33 5.49e-10 Developmental language disorder (linguistic errors); CRC cis rs2932538 0.922 rs6673930 chr1:113104887 A/G cg22162597 chr1:113214053 CAPZA1 0.72 10.34 0.5 6.91e-22 Systolic blood pressure;Diastolic blood pressure;Hypertension;Blood pressure; CRC cis rs7772486 0.790 rs9403756 chr6:146257761 C/G cg13319975 chr6:146136371 FBXO30 0.43 6.59 0.34 1.71e-10 Lobe attachment (rater-scored or self-reported); CRC cis rs2880765 0.835 rs7169429 chr15:86036648 C/T cg17133734 chr15:86042851 AKAP13 0.41 6.47 0.34 3.54e-10 Coronary artery disease; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg13393204 chr11:86748738 TMEM135 0.41 6.7 0.35 9.3e-11 Liver disease severity in Alagille syndrome; CRC cis rs7258465 1.000 rs2278238 chr19:18576484 T/C cg06953865 chr19:18549723 ISYNA1 -0.38 -5.8 -0.3 1.55e-8 Breast cancer; CRC cis rs172166 0.611 rs203882 chr6:28078502 G/A cg26587870 chr6:27730563 NA -0.39 -5.86 -0.31 1.13e-8 Cardiac Troponin-T levels; CRC cis rs7385804 0.761 rs568733 chr7:100311662 G/T cg16850897 chr7:100343110 ZAN 0.44 6.67 0.35 1.07e-10 Iron status biomarkers;Mean corpuscular hemoglobin;Hematocrit;Iron status biomarkers (transferrin saturation);Red blood cell count;Iron status biomarkers (iron levels);Mean corpuscular volume;Hematological parameters; CRC cis rs34375054 0.738 rs10846834 chr12:125625570 A/G cg06287003 chr12:125626642 AACS -0.52 -8.0 -0.4 2.15e-14 Post bronchodilator FEV1/FVC ratio; CRC cis rs9905704 0.647 rs6503892 chr17:57067086 G/A cg12560992 chr17:57184187 TRIM37 0.65 9.87 0.48 2.78e-20 Testicular germ cell tumor; CRC cis rs12023718 0.545 rs12024886 chr1:178547662 T/G cg00404053 chr1:178313656 RASAL2 0.63 7.1 0.36 7.76e-12 Obesity-related traits; CRC cis rs17767294 0.612 rs9461424 chr6:27919401 G/A cg25164649 chr6:28176230 NA 0.66 6.78 0.35 5.46e-11 Parkinson's disease; CRC cis rs7274811 0.744 rs209677 chr20:32140287 C/T cg14921437 chr20:32255988 NECAB3;C20orf134 0.45 6.38 0.33 5.87e-10 Height; CRC cis rs10883723 0.810 rs7917525 chr10:104246755 C/G cg04362960 chr10:104952993 NT5C2 -0.43 -6.02 -0.32 4.58e-9 Allergic disease (asthma, hay fever or eczema); CRC cis rs3091242 0.933 rs4649084 chr1:25752617 A/G cg20684491 chr1:25596433 NA 0.42 7.35 0.38 1.53e-12 Erythrocyte sedimentation rate; CRC cis rs10504229 1.000 rs67243305 chr8:58174958 G/A cg24829409 chr8:58192753 C8orf71 -0.68 -11.31 -0.53 2.83e-25 Developmental language disorder (linguistic errors); CRC cis rs34779708 0.966 rs4934732 chr10:35431684 T/C cg03585969 chr10:35415529 CREM 0.55 7.41 0.38 1.08e-12 Inflammatory bowel disease;Crohn's disease; CRC cis rs7312933 0.703 rs10459290 chr12:42613290 T/G cg19980929 chr12:42632907 YAF2 0.43 6.35 0.33 7.26e-10 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CRC trans rs1656966 1.000 rs1656966 chr3:186466252 C/T cg21099776 chr17:17739742 SREBF1 0.42 6.39 0.33 5.55e-10 Myopia (pathological); CRC cis rs1506636 0.927 rs11983604 chr7:123329754 T/G cg03229431 chr7:123269106 ASB15 -0.73 -11.6 -0.54 2.55e-26 Plateletcrit;Platelet count; CRC cis rs1980080 1.000 rs1980080 chr3:124911841 C/T cg01464473 chr3:124912499 SLC12A8 0.36 5.84 0.31 1.25e-8 Tonsillectomy; CRC cis rs7909074 1.000 rs7079573 chr10:45400406 G/A cg05187965 chr10:45406764 TMEM72 -0.36 -8.27 -0.41 3.42e-15 Mean corpuscular volume; CRC cis rs7613875 0.600 rs1138536 chr3:50153356 C/T cg24110177 chr3:50126178 RBM5 -0.57 -8.5 -0.42 6.93e-16 Body mass index; CRC cis rs68170813 0.523 rs79607134 chr7:107033619 A/T cg02696742 chr7:106810147 HBP1 -0.53 -5.9 -0.31 8.94e-9 Coronary artery disease; CRC trans rs2806561 1.000 rs654585 chr1:23514714 T/C cg20251008 chr1:161136045 PPOX 0.41 5.98 0.31 5.71e-9 Height; CRC cis rs2075371 0.933 rs2244548 chr7:133986234 A/G cg11752832 chr7:134001865 SLC35B4 0.5 7.71 0.39 1.54e-13 Mean platelet volume; CRC cis rs4808199 0.948 rs12982276 chr19:19459800 T/C cg03709012 chr19:19516395 GATAD2A 0.94 11.94 0.55 1.5e-27 Nonalcoholic fatty liver disease; CRC cis rs2281845 0.826 rs4915484 chr1:201076917 C/G cg22815214 chr1:201083145 CACNA1S 0.57 9.52 0.46 3.97e-19 Permanent tooth development; CRC cis rs9487051 0.872 rs9386790 chr6:109608460 G/T cg12927641 chr6:109611667 NA 0.36 6.48 0.34 3.37e-10 Reticulocyte fraction of red cells; CRC trans rs6015450 1.000 rs77506764 chr20:57751948 A/G cg22122715 chr13:96086023 CLDN10 -0.55 -6.07 -0.32 3.48e-9 Diastolic blood pressure;Systolic blood pressure;Hypertension;Blood pressure; CRC cis rs6860806 0.507 rs270601 chr5:131656997 T/C cg20512303 chr5:131592959 PDLIM4 0.41 7.11 0.37 7.12e-12 Breast cancer; CRC cis rs3736594 0.513 rs62141278 chr2:27768381 C/T cg27432699 chr2:27873401 GPN1 0.66 8.5 0.42 6.56e-16 Fasting blood glucose;Fasting blood glucose (BMI interaction); CRC cis rs13064411 0.696 rs7613546 chr3:113228019 G/A cg10517650 chr3:113235015 CCDC52 -0.42 -7.31 -0.37 2.02e-12 Response to simvastatin treatment (PCSK9 protein level change); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg13714271 chr9:33076774 SMU1 0.44 6.44 0.33 4.24e-10 Intelligence (multi-trait analysis); CRC trans rs2014572 0.967 rs10418480 chr19:57755055 C/T cg02674126 chr19:40336878 FBL 0.42 6.67 0.35 1.09e-10 Hyperactive-impulsive symptoms; CRC cis rs7615952 0.641 rs61048217 chr3:125807905 G/T cg18479299 chr3:125709523 NA -0.56 -6.6 -0.34 1.6e-10 Blood pressure (smoking interaction); CRC cis rs4692589 0.965 rs733672 chr4:170950243 C/A cg19918862 chr4:170955249 NA 0.4 6.36 0.33 6.94e-10 Anxiety disorder; CRC cis rs6952808 0.965 rs4719318 chr7:1887930 G/A cg02951883 chr7:2050386 MAD1L1 -0.66 -10.61 -0.5 8.31e-23 Bipolar disorder and schizophrenia; CRC cis rs12594515 0.600 rs12903858 chr15:45972166 A/G cg06207120 chr15:45996521 NA 0.25 5.82 0.31 1.43e-8 Waist circumference;Weight; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg27022615 chr11:70049105 FADD 0.45 6.57 0.34 1.99e-10 Response to antipsychotic treatment; CRC cis rs35110281 0.805 rs4818843 chr21:45006607 C/T cg04455712 chr21:45112962 RRP1B 0.4 7.75 0.39 1.14e-13 Mean corpuscular volume; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg04370476 chr3:49761188 GMPPB -0.39 -5.96 -0.31 6.51e-9 Myopia (pathological); CRC cis rs1451375 0.642 rs6963996 chr7:50559300 T/C cg18232548 chr7:50535776 DDC -0.43 -5.67 -0.3 3.11e-8 Malaria; CRC cis rs1552244 1.000 rs6442147 chr3:10078247 A/G cg18598329 chr3:10140678 FANCD2;C3orf24 -0.88 -12.6 -0.57 5.62e-30 Alzheimer's disease; CRC cis rs1797081 0.901 rs703059 chr10:16876402 G/A cg23933602 chr10:16859644 RSU1 1.06 20.05 0.74 5.59e-59 Platelet distribution width; CRC cis rs1008375 0.902 rs6844984 chr4:17651304 C/G cg04450456 chr4:17643702 FAM184B 0.36 5.86 0.31 1.11e-8 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs875971 0.767 rs61348003 chr7:66005934 C/T cg00343986 chr7:65444356 GUSB 0.45 6.23 0.32 1.42e-9 Aortic root size; CRC cis rs1865760 0.928 rs9295673 chr6:25912094 T/G cg17691542 chr6:26056736 HIST1H1C 0.55 8.25 0.41 3.99e-15 Height; CRC trans rs941408 0.515 rs7253128 chr19:2776982 C/T cg19676328 chr12:49525230 TUBA1B -0.47 -6.28 -0.33 1.08e-9 Total cholesterol levels; CRC trans rs7976838 0.908 rs12811364 chr12:60128317 A/G cg16974014 chr22:22007515 MIR130B 0.49 6.03 0.32 4.41e-9 Response to zileuton treatment in asthma (FEV1 change interaction); CRC cis rs10752881 1.000 rs10737235 chr1:182971816 T/C ch.1.3577855R chr1:183094577 LAMC1 0.87 15.2 0.64 6.75e-40 Colorectal cancer; CRC cis rs4862750 0.914 rs6553028 chr4:187876046 T/C cg07414643 chr4:187882934 NA 0.38 6.59 0.34 1.7e-10 Lobe attachment (rater-scored or self-reported); CRC trans rs62103177 0.810 rs62103175 chr18:77622467 C/T cg05926928 chr17:57297772 GDPD1 1.05 10.24 0.49 1.55e-21 Opioid sensitivity; CRC cis rs17401966 1.000 rs12136376 chr1:10296452 C/T cg19773385 chr1:10388646 KIF1B -0.56 -7.86 -0.4 5.59e-14 Hepatocellular carcinoma; CRC cis rs3087591 0.922 rs2953013 chr17:29496343 A/C cg24425628 chr17:29625626 OMG;NF1 -0.79 -13.36 -0.59 8.1e-33 Hip circumference; CRC cis rs3733585 0.699 rs28610447 chr4:9971517 T/C cg11266682 chr4:10021025 SLC2A9 -0.46 -9.17 -0.45 5.48e-18 Cleft plate (environmental tobacco smoke interaction); CRC cis rs35995292 0.534 rs2392604 chr7:38918012 C/T cg19327137 chr7:38886074 VPS41 0.67 11.43 0.53 1.07e-25 Subjective well-being (multi-trait analysis); CRC cis rs13191362 1.000 rs66789102 chr6:163104432 T/C cg14584255 chr6:163149320 PACRG;PARK2 0.44 6.4 0.33 5.31e-10 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg20483112 chr1:11954174 NA 0.46 6.07 0.32 3.58e-9 Thyroid stimulating hormone; CRC cis rs79976124 0.719 rs34488909 chr6:66637850 T/C cg07460842 chr6:66804631 NA 0.7 8.78 0.44 9.05e-17 Type 2 diabetes; CRC cis rs7618915 0.570 rs11714088 chr3:52758942 A/C cg15147215 chr3:52552868 STAB1 -0.61 -10.07 -0.49 5.69e-21 Bipolar disorder; CRC cis rs600806 0.888 rs3768497 chr1:109866230 T/C cg23032129 chr1:109941072 SORT1 -0.27 -5.8 -0.3 1.59e-8 Intelligence (multi-trait analysis); CRC cis rs6674970 1.000 rs7546304 chr1:151114484 C/G cg03258749 chr1:151040405 MLLT11 -0.48 -7.37 -0.38 1.43e-12 Childhood ear infection; CRC cis rs2836974 0.568 rs4816620 chr21:40613786 A/G cg22974920 chr21:40686053 BRWD1 -0.43 -5.96 -0.31 6.4e-9 Cognitive function; CRC cis rs2439831 0.850 rs3825783 chr15:44102309 A/G cg02155558 chr15:43621948 ADAL;LCMT2 0.73 7.67 0.39 2.01e-13 Lung cancer in ever smokers; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg02841941 chr3:152552615 P2RY1 0.44 6.28 0.33 1.05e-9 Response to antipsychotic treatment; CRC cis rs314370 0.904 rs13244629 chr7:100509253 A/C cg10426581 chr7:100472382 SRRT 0.61 6.9 0.36 2.67e-11 Resting heart rate; CRC cis rs9640161 0.750 rs11769348 chr7:150026753 C/T cg12556325 chr7:150026731 C7orf29;LRRC61 0.47 7.21 0.37 3.83e-12 Blood protein levels;Circulating chemerin levels; CRC cis rs6541297 1.000 rs6541297 chr1:230283506 G/A cg20703242 chr1:230279135 GALNT2 0.53 8.23 0.41 4.47e-15 Coronary artery disease; CRC cis rs60871478 0.541 rs56964970 chr7:910791 G/C cg13798912 chr7:905769 UNC84A -0.64 -7.05 -0.36 1.09e-11 Cerebrospinal P-tau181p levels; CRC cis rs7591163 1.000 rs1039665 chr2:228717392 A/G cg14646075 chr2:228736089 WDR69 -0.46 -6.17 -0.32 1.99e-9 Blood pressure; CRC cis rs17767392 0.718 rs61989206 chr14:71686049 A/T cg13720639 chr14:72061746 SIPA1L1 -0.52 -6.72 -0.35 7.83e-11 Mitral valve prolapse; CRC cis rs8062405 1.000 rs7205323 chr16:28865892 C/T cg08761264 chr16:28874980 SH2B1 -0.44 -5.84 -0.31 1.27e-8 Cognitive ability (multi-trait analysis);Cognitive ability; CRC trans rs66887589 0.967 rs59516282 chr4:120502016 G/A cg25214090 chr10:38739885 LOC399744 -0.43 -6.58 -0.34 1.82e-10 Diastolic blood pressure; CRC cis rs7412746 0.621 rs72704656 chr1:150828307 A/G cg15448220 chr1:150897856 SETDB1 0.52 7.28 0.37 2.54e-12 Melanoma; CRC cis rs931127 0.658 rs12787843 chr11:65477306 A/C cg27068330 chr11:65405492 SIPA1 -0.44 -5.97 -0.31 6.06e-9 Systemic lupus erythematosus; CRC cis rs7605827 0.930 rs11900088 chr2:15613994 T/C cg19274914 chr2:15703543 NA 0.39 5.9 0.31 8.83e-9 Educational attainment (years of education); CRC cis rs10256972 0.552 rs2960831 chr7:1201192 A/T cg22907277 chr7:1156413 C7orf50 0.64 9.7 0.47 1e-19 Longevity;Endometriosis; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg18570997 chr7:129710291 KLHDC10 0.48 6.97 0.36 1.73e-11 Response to antipsychotic treatment; CRC cis rs17345786 0.798 rs1609159 chr3:101275902 A/C cg11279151 chr3:101281821 RG9MTD1 -0.69 -9.35 -0.46 1.4e-18 Colonoscopy-negative controls vs population controls; CRC cis rs1059312 0.778 rs4760594 chr12:129296865 T/A cg23521905 chr12:129298690 SLC15A4;MGC16384 0.38 6.52 0.34 2.64e-10 Systemic lupus erythematosus; CRC cis rs911119 0.913 rs4815222 chr20:23576964 A/G cg16589663 chr20:23618590 CST3 -0.44 -6.19 -0.32 1.77e-9 Chronic kidney disease; CRC cis rs995000 0.783 rs6686331 chr1:63182135 C/T cg19896129 chr1:63156450 NA -0.42 -6.47 -0.34 3.55e-10 Triglyceride levels; CRC trans rs7618501 0.932 rs4855850 chr3:49761571 G/A cg21665057 chr3:196295764 WDR53;FBXO45 -0.86 -16.05 -0.66 3.08e-43 Intelligence (multi-trait analysis); CRC cis rs6426558 0.537 rs2813969 chr1:227404082 T/C cg10327440 chr1:227177885 CDC42BPA 0.44 6.62 0.34 1.43e-10 Neutrophil percentage of white cells; CRC cis rs3741151 0.773 rs17244596 chr11:73179236 A/G cg17517138 chr11:73019481 ARHGEF17 1.04 8.44 0.42 1.01e-15 GIP levels in response to oral glucose tolerance test (120 minutes); CRC cis rs28493229 0.748 rs10426415 chr19:41183590 A/G cg21869046 chr19:41225005 ITPKC 0.41 6.22 0.32 1.51e-9 Kawasaki disease; CRC cis rs10911232 0.507 rs6664995 chr1:183017345 T/C ch.1.3577855R chr1:183094577 LAMC1 0.83 14.57 0.63 1.8e-37 Hypertriglyceridemia; CRC cis rs62408225 0.962 rs6899623 chr6:90986559 A/G cg06866423 chr6:90926672 BACH2 0.48 7.94 0.4 3.28e-14 Eosinophil counts;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC cis rs185694 0.947 rs595451 chr13:30896848 T/C cg04551440 chr13:30881194 KATNAL1 -0.6 -6.22 -0.32 1.54e-9 Antineutrophil cytoplasmic antibody-associated vasculitis; CRC cis rs6502050 0.835 rs8067138 chr17:80111026 T/C cg25804541 chr17:80189381 SLC16A3 -0.31 -5.97 -0.31 6.08e-9 Life satisfaction; CRC cis rs9322193 0.962 rs10452626 chr6:150088617 T/C cg13206674 chr6:150067644 NUP43 0.57 8.19 0.41 5.85e-15 Lung cancer; CRC cis rs6912958 0.559 rs376633 chr6:88042785 T/C cg08069147 chr6:88032118 GJB7;C6orf162 0.71 11.56 0.54 3.5e-26 Monocyte percentage of white cells; CRC cis rs7666738 0.830 rs36028444 chr4:98968635 G/T cg05340658 chr4:99064831 C4orf37 0.6 9.45 0.46 6.71e-19 Colonoscopy-negative controls vs population controls; CRC cis rs4692589 1.000 rs12643956 chr4:170932819 A/C cg19918862 chr4:170955249 NA 0.38 6.23 0.32 1.43e-9 Anxiety disorder; CRC cis rs4664293 0.647 rs1425040 chr2:160428423 G/A cg08347373 chr2:160653686 CD302 -0.38 -6.41 -0.33 4.95e-10 Monocyte percentage of white cells; CRC cis rs12134245 0.776 rs625525 chr1:91997593 C/T cg21854759 chr1:92012499 NA -0.59 -10.04 -0.48 7.21e-21 Breast cancer; CRC cis rs10479542 0.544 rs7706275 chr5:178990305 A/G cg14820908 chr5:178986412 RUFY1 0.38 5.87 0.31 1.08e-8 Lung cancer; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg25447549 chr5:150603693 CCDC69 0.47 6.07 0.32 3.62e-9 Thyroid stimulating hormone; CRC cis rs13064411 0.735 rs7636128 chr3:113133701 A/T cg18753928 chr3:113234510 CCDC52 -0.51 -7.3 -0.37 2.16e-12 Response to simvastatin treatment (PCSK9 protein level change); CRC cis rs1865760 0.566 rs4529296 chr6:26083135 C/G cg18357526 chr6:26021779 HIST1H4A 0.43 6.09 0.32 3.08e-9 Height; CRC cis rs4065321 0.522 rs11078930 chr17:38141955 C/T cg17467752 chr17:38218738 THRA -0.49 -7.14 -0.37 5.88e-12 White blood cell count (basophil);White blood cell count; CRC cis rs57466243 1 rs57466243 chr17:27059666 T/A cg16670446 chr17:27188758 MIR451;MIR144 -0.39 -7.06 -0.36 1.02e-11 Reticulocyte count; CRC cis rs10927875 0.662 rs698893 chr1:16302982 C/T cg24140574 chr1:16342155 HSPB7 0.44 6.53 0.34 2.47e-10 Dilated cardiomyopathy; CRC cis rs362272 0.524 rs13150241 chr4:3367281 A/G cg11522145 chr4:3412961 RGS12 -0.41 -6.27 -0.33 1.16e-9 Serum sulfate level; CRC cis rs490234 0.783 rs4838278 chr9:128403509 T/C cg14078157 chr9:128172775 NA -0.4 -6.8 -0.35 4.94e-11 Mean arterial pressure; CRC cis rs4713118 0.547 rs2116981 chr6:28067951 T/G cg21251018 chr6:28226885 NKAPL 0.48 6.26 0.33 1.17e-9 Parkinson's disease; CRC cis rs11997175 0.524 rs12164218 chr8:33669658 G/C cg04338863 chr8:33670619 NA 0.46 7.02 0.36 1.3e-11 Body mass index; CRC cis rs2124969 0.562 rs4665164 chr2:161070078 T/G cg03641300 chr2:160917029 PLA2R1 -0.59 -9.41 -0.46 8.85e-19 Waist circumference adjusted for body mass index; CRC cis rs7487075 0.859 rs2307061 chr12:46758494 A/G cg22049899 chr12:47219821 SLC38A4 0.31 5.72 0.3 2.37e-8 Itch intensity from mosquito bite; CRC cis rs9341808 0.718 rs6910201 chr6:80904938 G/C cg08355045 chr6:80787529 NA 0.43 6.94 0.36 2.08e-11 Sitting height ratio; CRC cis rs9303280 0.806 rs35736272 chr17:38032680 T/C cg00129232 chr17:37814104 STARD3 -0.47 -7.6 -0.39 3.03e-13 Self-reported allergy; CRC cis rs2839186 0.814 rs12482209 chr21:47664275 C/G cg13012494 chr21:47604986 C21orf56 -0.42 -6.61 -0.34 1.58e-10 Testicular germ cell tumor; CRC cis rs9381040 0.610 rs4140580 chr6:41041742 C/T cg03644281 chr6:41068752 NFYA;LOC221442 -0.43 -6.01 -0.31 4.86e-9 Alzheimer's disease (late onset); CRC cis rs17376456 0.825 rs34967135 chr5:93221785 G/A cg09848695 chr5:92956644 FAM172A;MIR2277 0.67 6.0 0.31 5.29e-9 Diabetic retinopathy; CRC cis rs2011503 0.941 rs112253053 chr19:19425145 T/A cg11584989 chr19:19387371 SF4 0.56 6.4 0.33 5.2e-10 Bipolar disorder; CRC cis rs6684514 1.000 rs10752615 chr1:156248609 T/C cg16558208 chr1:156270281 VHLL 0.59 9.2 0.45 4.08e-18 Mean corpuscular hemoglobin concentration;Glycated hemoglobin levels; CRC cis rs4523957 0.928 rs403553 chr17:2191260 C/T cg16513277 chr17:2031491 SMG6 0.51 8.72 0.43 1.35e-16 Autism spectrum disorder or schizophrenia;Schizophrenia; CRC trans rs61931739 0.500 rs7303318 chr12:34467789 T/C cg13010199 chr12:38710504 ALG10B 0.46 6.5 0.34 2.92e-10 Morning vs. evening chronotype; CRC cis rs4665809 1.000 rs3910272 chr2:26287842 T/A cg04944784 chr2:26401820 FAM59B -0.65 -8.02 -0.4 1.93e-14 Gut microbiome composition (summer); CRC cis rs10504229 0.953 rs66509078 chr8:58174734 G/C cg02725872 chr8:58115012 NA -0.38 -6.43 -0.33 4.44e-10 Developmental language disorder (linguistic errors); CRC cis rs7937682 0.855 rs7934922 chr11:111500026 T/C cg19812747 chr11:111475976 SIK2 -0.58 -9.76 -0.47 6.21e-20 Primary sclerosing cholangitis; CRC cis rs4713118 0.869 rs2056925 chr6:27690905 A/G cg19041857 chr6:27730383 NA -0.43 -6.25 -0.33 1.27e-9 Parkinson's disease; CRC cis rs344364 0.511 rs2982446 chr16:1947153 C/T cg03013636 chr16:1946785 NA 0.59 7.18 0.37 4.64e-12 Glomerular filtration rate in chronic kidney disease; CRC cis rs72781680 0.800 rs72790306 chr2:24111311 T/G cg08917208 chr2:24149416 ATAD2B 1.02 9.74 0.47 7.31e-20 Lymphocyte counts; CRC cis rs10128264 0.902 rs1250582 chr10:80973447 G/T cg20744163 chr10:80999841 ZMIZ1 -0.39 -6.73 -0.35 7.78e-11 Response to methotrexate in juvenile idiopathic arthritis; CRC cis rs11098499 0.865 rs11098513 chr4:120316075 A/G cg09307838 chr4:120376055 NA 0.71 10.93 0.52 6.14e-24 Corneal astigmatism; CRC cis rs7591163 1.000 rs2056566 chr2:228713241 G/A cg01216370 chr2:228736459 WDR69 -0.45 -5.7 -0.3 2.68e-8 Blood pressure; CRC cis rs71403859 0.502 rs71403847 chr16:71468226 T/C cg08717414 chr16:71523259 ZNF19 -0.95 -9.26 -0.45 2.72e-18 Post bronchodilator FEV1; CRC trans rs916888 0.773 rs199451 chr17:44801784 G/A cg13957321 chr17:43675089 NA 0.49 6.14 0.32 2.32e-9 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs10888329 0.744 rs7533755 chr1:248359891 A/G cg00666640 chr1:248458726 OR2T12 0.44 7.07 0.36 9.39e-12 Autism spectrum disorder; CRC cis rs208520 0.661 rs1100950 chr6:66827285 A/C cg07460842 chr6:66804631 NA -1.1 -15.01 -0.64 3.68e-39 Exhaled nitric oxide output; CRC cis rs6502050 0.835 rs12600852 chr17:80104593 G/A cg19223190 chr17:80058835 NA 0.4 6.36 0.33 6.88e-10 Life satisfaction; CRC cis rs3736594 0.513 rs6704596 chr2:27796927 A/G cg27432699 chr2:27873401 GPN1 0.64 8.52 0.43 5.74e-16 Fasting blood glucose;Fasting blood glucose (BMI interaction); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg16035638 chr15:66797798 RPL4;ZWILCH 0.41 6.05 0.32 3.86e-9 Intelligence (multi-trait analysis); CRC cis rs2635047 0.615 rs2684833 chr18:44719428 C/G cg19077165 chr18:44547161 KATNAL2 0.43 6.35 0.33 7.24e-10 Educational attainment; CRC cis rs40363 0.645 rs250630 chr16:3524242 C/T cg00484396 chr16:3507460 NAT15 0.53 7.92 0.4 3.8e-14 Tuberculosis; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg04946603 chr15:41221376 DLL4 0.43 6.95 0.36 2.02e-11 Liver disease severity in Alagille syndrome; CRC cis rs870825 0.616 rs6833858 chr4:185639961 C/T cg04058563 chr4:185651563 MLF1IP 0.79 10.35 0.5 6.5600000000000005e-22 Blood protein levels; CRC cis rs9549367 0.826 rs1885688 chr13:113894236 G/T cg00898013 chr13:113819073 PROZ -0.43 -6.29 -0.33 1.01e-9 Platelet distribution width; CRC cis rs7319311 1.000 rs7320755 chr13:111031092 C/G cg05272587 chr13:111038400 COL4A2 -0.39 -6.15 -0.32 2.26e-9 Bipolar disorder and schizophrenia; CRC cis rs2270875 1.000 rs75457232 chr8:132926435 A/G cg24184792 chr8:132919238 EFR3A -0.69 -6.74 -0.35 7.27e-11 Response to cholinesterase inhibitors in Alzheimer's disease; CRC cis rs77956314 0.515 rs12299065 chr12:117442304 A/G cg02017074 chr12:117425053 FBXW8 0.65 8.4 0.42 1.38e-15 Subcortical brain region volumes;Hippocampal volume; CRC cis rs9302065 0.681 rs9524903 chr13:95963565 A/G cg24476569 chr13:95954382 ABCC4 -0.4 -5.94 -0.31 7.06e-9 Blood metabolite levels; CRC cis rs2108622 0.727 rs12609900 chr19:15982414 G/A cg13772218 chr19:15982569 NA 0.49 6.97 0.36 1.75e-11 Circulating phylloquinone levels;Vitamin E levels;Acenocoumarol maintenance dosage;Response to Vitamin E supplementation;Metabolite levels;Warfarin maintenance dose; CRC cis rs7945718 0.621 rs7931934 chr11:12679245 T/G cg25843174 chr11:12811716 TEAD1 0.41 7.71 0.39 1.49e-13 Educational attainment (years of education); CRC cis rs6831352 0.879 rs29001212 chr4:100051877 T/C cg13256891 chr4:100009986 ADH5 -0.65 -8.86 -0.44 5.21e-17 Alcohol dependence; CRC cis rs7647973 0.925 rs6769821 chr3:49244657 G/A cg07636037 chr3:49044803 WDR6 0.62 6.99 0.36 1.58e-11 Menarche (age at onset); CRC cis rs9323205 0.861 rs55763867 chr14:51608567 G/A cg23942311 chr14:51606299 NA -0.57 -7.19 -0.37 4.43e-12 Cancer; CRC cis rs7811142 1.000 rs2406253 chr7:100077273 A/G cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.73 9.87 0.48 2.71e-20 Platelet count; CRC cis rs704795 0.805 rs1728926 chr2:27612937 A/G cg24768116 chr2:27665128 KRTCAP3 -0.35 -7.85 -0.4 6.05e-14 Menopause (age at onset); CRC cis rs6860806 0.507 rs272872 chr5:131675864 C/T cg02033258 chr5:131593261 PDLIM4 -0.35 -6.03 -0.32 4.29e-9 Breast cancer; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg10894806 chr6:6724955 NA 0.43 5.97 0.31 6.11e-9 Response to antipsychotic treatment; CRC cis rs3785888 0.569 rs11655668 chr17:45007632 A/G cg16759221 chr17:45003025 GOSR2 0.61 9.08 0.45 1.02e-17 Cleft lip with or without cleft palate; CRC cis rs8177253 1.000 rs8177253 chr3:133480192 A/G cg01448562 chr3:133502909 NA 0.55 9.46 0.46 6.31e-19 Iron status biomarkers; CRC cis rs6445967 1.000 rs35495842 chr3:58310250 T/C cg23715586 chr3:58305044 RPP14 0.37 6.01 0.31 4.82e-9 Platelet count; CRC cis rs1451375 1.000 rs10247443 chr7:50620586 G/A cg18232548 chr7:50535776 DDC 0.48 6.79 0.35 5.35e-11 Malaria; CRC cis rs3806843 0.735 rs2563306 chr5:140070017 C/T cg19875535 chr5:140030758 IK -0.63 -10.37 -0.5 5.57e-22 Depressive symptoms (multi-trait analysis); CRC cis rs2408955 0.521 rs10875749 chr12:48531917 T/A cg00601486 chr12:48723148 H1FNT -0.35 -6.82 -0.35 4.3e-11 Glycated hemoglobin levels; CRC cis rs72634258 0.945 rs397349 chr1:8074872 A/C cg00042356 chr1:8021962 PARK7 0.54 6.87 0.35 3.13e-11 Inflammatory bowel disease; CRC cis rs4148883 0.675 rs10000357 chr4:100099942 G/C cg13256891 chr4:100009986 ADH5 0.42 6.09 0.32 3.07e-9 Alcohol dependence; CRC cis rs1218582 0.510 rs2878411 chr1:154823545 C/T cg06221963 chr1:154839813 KCNN3 -0.56 -9.08 -0.45 1.06e-17 Prostate cancer; CRC cis rs3785574 0.962 rs57553639 chr17:61848499 C/T cg11494091 chr17:61959527 GH2 0.38 5.93 0.31 7.85e-9 Height; CRC cis rs4363385 0.747 rs7529110 chr1:152966247 A/C cg25856811 chr1:152973957 SPRR3 -0.26 -7.3 -0.37 2.23e-12 Inflammatory skin disease; CRC cis rs875971 0.830 rs427575 chr7:65519219 A/G cg11764359 chr7:65958608 NA 0.57 8.95 0.44 2.73e-17 Aortic root size; CRC cis rs1865760 0.566 rs9358902 chr6:26058570 C/G cg18357526 chr6:26021779 HIST1H4A 0.41 5.82 0.31 1.43e-8 Height; CRC cis rs9296736 1.000 rs7450517 chr6:53902843 G/A cg04374786 chr6:53939321 C6orf142 0.46 7.41 0.38 1.04e-12 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs13191362 0.872 rs13215538 chr6:163037975 T/C cg06582575 chr6:163149167 PACRG;PARK2 0.9 11.33 0.53 2.42e-25 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs9916302 0.706 rs667239 chr17:37442241 A/G cg07936489 chr17:37558343 FBXL20 0.92 12.37 0.56 4.2e-29 Glomerular filtration rate (creatinine); CRC cis rs8005677 0.926 rs34344888 chr14:23387585 A/G cg01529538 chr14:23388837 RBM23 0.4 6.18 0.32 1.86e-9 Cognitive ability (multi-trait analysis); CRC cis rs6547741 0.935 rs4665384 chr2:27848397 A/G cg27432699 chr2:27873401 GPN1 0.79 14.23 0.62 3.74e-36 Oral cavity cancer; CRC trans rs561341 0.941 rs4795664 chr17:30233467 C/T cg20587970 chr11:113659929 NA -1.03 -12.7 -0.57 2.48e-30 Hip circumference adjusted for BMI; CRC cis rs34779708 0.931 rs2244100 chr10:35323636 G/A cg03585969 chr10:35415529 CREM -0.57 -7.68 -0.39 1.87e-13 Inflammatory bowel disease;Crohn's disease; CRC cis rs6960043 0.714 rs4719430 chr7:15047280 C/G cg19272540 chr7:15055459 NA -0.22 -5.97 -0.31 6.17e-9 Type 2 diabetes; CRC cis rs2573652 0.722 rs11858932 chr15:100542763 G/A cg00587665 chr15:100533223 ADAMTS17 -0.35 -6.14 -0.32 2.4e-9 Height; CRC cis rs765787 0.530 rs4238377 chr15:45541981 A/G cg24006582 chr15:45444508 DUOX1 -0.57 -8.63 -0.43 2.62e-16 Uric acid levels; CRC cis rs11098499 0.863 rs17050695 chr4:120489527 G/T cg24375607 chr4:120327624 NA 0.49 7.68 0.39 1.85e-13 Corneal astigmatism; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg07698384 chr15:25684465 UBE3A 0.49 6.23 0.32 1.41e-9 Thyroid stimulating hormone; CRC cis rs58688157 0.883 rs7936397 chr11:577534 G/A cg09218773 chr11:619014 MUPCDH -0.36 -5.64 -0.3 3.62e-8 Systemic lupus erythematosus; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg13655938 chr17:40540819 STAT3 0.46 6.48 0.34 3.4e-10 Response to antipsychotic treatment; CRC cis rs11711311 1.000 rs62268168 chr3:113489447 A/T cg15478005 chr3:113465772 ATP6V1A;NAA50 0.42 5.75 0.3 2.08e-8 IgG glycosylation; CRC cis rs1580019 0.510 rs4723162 chr7:32543804 C/A cg06627557 chr7:32535165 LSM5;AVL9 0.97 18.93 0.72 1.44e-54 Cognitive ability; CRC cis rs8180040 0.701 rs7617689 chr3:46996442 C/T cg02527881 chr3:46936655 PTH1R 0.4 7.32 0.37 1.89e-12 Colorectal cancer; CRC cis rs425277 1.000 rs425277 chr1:2069172 C/T cg24578937 chr1:2090814 PRKCZ 0.67 11.73 0.54 8.47e-27 Height; CRC cis rs8067545 1.000 rs56142708 chr17:19934963 A/C cg13482628 chr17:19912719 NA 0.52 8.11 0.41 9.88e-15 Schizophrenia; CRC cis rs1552244 1.000 rs17032295 chr3:10086680 C/T cg16606324 chr3:10149918 C3orf24 0.7 9.76 0.47 6.23e-20 Alzheimer's disease; CRC cis rs6662572 0.737 rs56047133 chr1:46517228 C/T cg03123370 chr1:45965343 CCDC163P;MMACHC 0.46 5.98 0.31 5.76e-9 Blood protein levels; CRC cis rs2153535 0.562 rs6901765 chr6:8455436 A/T cg07606381 chr6:8435919 SLC35B3 0.68 10.91 0.52 7.29e-24 Motion sickness; CRC cis rs853679 0.517 rs9393894 chr6:28112562 A/G cg12172441 chr6:28176163 NA 0.64 7.53 0.38 5.03e-13 Depression; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg15923342 chr7:130353794 COPG2;TSGA13 0.42 6.53 0.34 2.56e-10 Intelligence (multi-trait analysis); CRC cis rs11168351 1.000 rs11168351 chr12:48403765 C/T cg21466736 chr12:48725269 NA -0.52 -8.02 -0.4 1.9e-14 Bipolar disorder and schizophrenia; CRC cis rs13118159 0.778 rs12650998 chr4:1338832 T/C cg16405210 chr4:1374714 KIAA1530 -0.4 -5.67 -0.3 3.1e-8 Longevity; CRC cis rs9381040 0.610 rs4140579 chr6:41041752 G/A cg04346459 chr6:41068666 NFYA;LOC221442 -0.4 -5.82 -0.31 1.43e-8 Alzheimer's disease (late onset); CRC cis rs875971 0.862 rs6959268 chr7:65812966 G/A cg18876405 chr7:65276391 NA -0.52 -8.56 -0.43 4.45e-16 Aortic root size; CRC cis rs7959452 0.535 rs10784771 chr12:69621264 A/G cg14784868 chr12:69753453 YEATS4 0.74 11.83 0.55 3.79e-27 Blood protein levels; CRC cis rs853679 0.607 rs34661125 chr6:28281894 G/A cg12185399 chr6:27640341 NA 0.83 6.03 0.32 4.38e-9 Depression; CRC cis rs10751667 0.643 rs10794343 chr11:925493 C/T ch.11.42038R chr11:967971 AP2A2 0.61 10.35 0.5 6.31e-22 Alzheimer's disease (late onset); CRC cis rs7772486 0.790 rs2247206 chr6:146216184 C/T cg13319975 chr6:146136371 FBXO30 -0.38 -5.84 -0.31 1.29e-8 Lobe attachment (rater-scored or self-reported); CRC cis rs881375 0.967 rs2416805 chr9:123676482 T/C cg09419670 chr9:123605666 PSMD5;LOC253039 0.59 8.7 0.43 1.6e-16 Rheumatoid arthritis; CRC cis rs13108904 0.870 rs4974543 chr4:1251222 A/G cg05665937 chr4:1216051 CTBP1 0.43 6.44 0.33 4.34e-10 Obesity-related traits; CRC cis rs9875589 0.509 rs2733548 chr3:14094478 C/T cg14375111 chr3:14165186 TMEM43;CHCHD4 0.41 6.01 0.31 5.04e-9 Ovarian reserve; CRC cis rs5769765 0.908 rs9627800 chr22:50319351 T/C cg02269571 chr22:50332266 NA -0.62 -7.82 -0.4 7.32e-14 Schizophrenia; CRC cis rs9837602 1.000 rs10212525 chr3:99713377 T/C cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G 0.48 5.74 0.3 2.13e-8 Breast cancer; CRC cis rs1018836 0.923 rs62526886 chr8:91627676 G/A cg16814680 chr8:91681699 NA -0.77 -12.18 -0.56 1.96e-28 Ejection fraction in Tripanosoma cruzi seropositivity; CRC cis rs2415984 0.579 rs1389608 chr14:46957777 C/A cg14871534 chr14:47121158 RPL10L -0.42 -5.92 -0.31 8.18e-9 Number of children ever born; CRC cis rs7917772 0.510 rs2001389 chr10:104375258 G/A cg11453585 chr10:104263688 ACTR1A;SUFU 0.81 14.95 0.64 6.44e-39 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC cis rs7618915 0.524 rs12488461 chr3:52698417 T/C cg18099408 chr3:52552593 STAB1 -0.44 -7.16 -0.37 5.27e-12 Bipolar disorder; CRC cis rs2721195 1.000 rs11542372 chr8:145677089 G/A cg11211951 chr8:145729740 GPT -0.37 -6.45 -0.33 4.05e-10 Age at first birth; CRC cis rs936229 0.656 rs2290572 chr15:75130573 A/G cg09165964 chr15:75287851 SCAMP5 0.43 6.81 0.35 4.58e-11 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); CRC cis rs7927771 0.524 rs10838760 chr11:47786414 A/G cg20307385 chr11:47447363 PSMC3 0.45 6.57 0.34 1.92e-10 Subjective well-being; CRC trans rs916888 0.821 rs199509 chr17:44858728 G/A cg22433210 chr17:43662623 NA -0.82 -9.07 -0.45 1.11e-17 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs73206853 0.841 rs73191836 chr12:110966177 G/T cg12870014 chr12:110450643 ANKRD13A 0.77 7.44 0.38 8.61e-13 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC cis rs1832871 0.672 rs62437399 chr6:158784251 C/A cg07165851 chr6:158734300 TULP4 0.62 7.8 0.39 8.5e-14 Height; CRC cis rs853679 0.517 rs6932109 chr6:28078303 A/G cg15786705 chr6:28176104 NA -0.73 -9.56 -0.47 2.89e-19 Depression; CRC cis rs7901135 0.962 rs7067550 chr10:60562236 C/T cg23799393 chr10:60588674 BICC1 -0.37 -5.76 -0.3 1.97e-8 Morning vs. evening chronotype; CRC cis rs7618915 0.524 rs35249778 chr3:52661640 G/C cg18099408 chr3:52552593 STAB1 -0.43 -7.13 -0.37 6.6e-12 Bipolar disorder; CRC cis rs644799 1.000 rs509720 chr11:95562771 T/C cg25622487 chr11:95524042 FAM76B;CEP57 0.76 11.99 0.55 9.59e-28 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs713587 0.607 rs6725517 chr2:25129473 A/G cg04586622 chr2:25135609 ADCY3 -0.57 -10.75 -0.51 2.75e-23 Body mass index in non-asthmatics; CRC cis rs2404602 0.608 rs17361504 chr15:76601871 A/G cg23625390 chr15:77176239 SCAPER 0.39 5.81 0.31 1.47e-8 Blood metabolite levels; CRC cis rs10751667 0.643 rs7394436 chr11:970373 G/C ch.11.42038R chr11:967971 AP2A2 0.58 9.98 0.48 1.16e-20 Alzheimer's disease (late onset); CRC trans rs79464052 0.677 rs77605361 chr5:140954026 A/G cg05255351 chr5:1503979 LPCAT1 -0.55 -6.91 -0.36 2.58e-11 Diffuse large B cell lymphoma; CRC cis rs4499344 0.576 rs259280 chr19:33161452 C/T cg08127369 chr19:33164662 ANKRD27 0.39 5.95 0.31 6.81e-9 Mean platelet volume; CRC cis rs7666738 0.830 rs10034619 chr4:98970067 G/C cg05340658 chr4:99064831 C4orf37 0.57 8.76 0.43 1.05e-16 Colonoscopy-negative controls vs population controls; CRC cis rs9914544 0.762 rs4322727 chr17:18798573 A/T cg26306683 chr17:18585705 ZNF286B -0.4 -5.94 -0.31 7.32e-9 Educational attainment (years of education); CRC cis rs9399137 0.529 rs7739722 chr6:135282225 T/C cg24558204 chr6:135376177 HBS1L 0.58 8.54 0.43 4.96e-16 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; CRC cis rs2239547 0.603 rs59989280 chr3:53098875 T/C cg15147215 chr3:52552868 STAB1 -0.42 -5.84 -0.31 1.25e-8 Schizophrenia; CRC cis rs853679 0.542 rs6934769 chr6:28090931 A/G cg03623178 chr6:28175578 NA 0.96 12.57 0.57 7.23e-30 Depression; CRC cis rs875971 1.000 rs937495 chr7:65779798 A/G cg18912574 chr7:65842487 NCRNA00174 -0.36 -6.12 -0.32 2.68e-9 Aortic root size; CRC cis rs780096 0.526 rs1647266 chr2:27693485 T/C cg21248554 chr2:27665150 KRTCAP3 -0.33 -7.82 -0.4 7.44e-14 Total body bone mineral density; CRC cis rs7677751 0.806 rs4864860 chr4:55090021 T/C cg13615338 chr4:55094005 PDGFRA 0.42 6.19 0.32 1.81e-9 Corneal astigmatism; CRC cis rs35146811 0.771 rs6465762 chr7:99620554 G/A cg03265037 chr7:99691720 MIR25;MCM7;MIR106B;MIR93 0.43 5.61 0.3 4.41e-8 Coronary artery disease; CRC cis rs8060686 0.641 rs59708959 chr16:68123916 A/T cg26727032 chr16:67993705 SLC12A4 -0.59 -7.19 -0.37 4.52e-12 HDL cholesterol;Metabolic syndrome; CRC cis rs7618915 0.501 rs11130308 chr3:52639257 G/C cg18404041 chr3:52824283 ITIH1 -0.41 -8.59 -0.43 3.47e-16 Bipolar disorder; CRC cis rs11190604 1.000 rs10883509 chr10:102296461 C/T cg16342193 chr10:102329863 NA -0.36 -5.98 -0.31 5.74e-9 Palmitoleic acid (16:1n-7) levels; CRC cis rs561341 0.883 rs2074102 chr17:30228884 G/A cg19193384 chr17:30244184 NA -0.58 -7.01 -0.36 1.33e-11 Hip circumference adjusted for BMI; CRC cis rs3126085 0.935 rs7550106 chr1:152197202 C/T cg09127314 chr1:152161683 NA -0.45 -5.94 -0.31 7.08e-9 Atopic dermatitis; CRC cis rs7626444 0.625 rs7648479 chr3:196477213 G/C cg12930392 chr3:196481615 PAK2 0.39 7.06 0.36 9.86e-12 Monocyte count; CRC cis rs6546324 0.625 rs2861686 chr2:67838051 A/T cg15745817 chr2:67799979 NA -0.55 -9.6 -0.47 2.17e-19 Endometriosis; CRC cis rs728616 0.867 rs116994688 chr10:81738137 G/C cg11900509 chr10:81946545 ANXA11 -0.68 -6.82 -0.35 4.39e-11 Chronic obstructive pulmonary disease-related biomarkers; CRC trans rs4332037 0.615 rs62435127 chr7:1884937 A/G cg11693508 chr17:37793320 STARD3 0.64 8.22 0.41 4.72e-15 Bipolar disorder; CRC cis rs10979 0.964 rs9496682 chr6:143898805 A/G cg25407410 chr6:143891975 LOC285740 -0.85 -13.99 -0.61 3.18e-35 Hypospadias; CRC cis rs11628318 0.713 rs4900543 chr14:103029024 T/C cg23461800 chr14:103021989 NA -0.75 -9.93 -0.48 1.71e-20 Platelet count; CRC cis rs11212617 1.000 rs227092 chr11:108236783 G/T cg12106634 chr11:108092400 ATM;NPAT 0.44 6.48 0.34 3.33e-10 Response to metformin in type 2 diabetes (glycemic); CRC cis rs28386778 0.830 rs2597637 chr17:61875066 T/G cg25654072 chr17:61904446 PSMC5;FTSJ3 0.74 11.5 0.54 6.02e-26 Prudent dietary pattern; CRC cis rs12594515 1.000 rs8032361 chr15:45988553 T/C cg01629716 chr15:45996671 NA 0.41 8.46 0.42 9.03e-16 Waist circumference;Weight; CRC cis rs7772486 0.701 rs11155438 chr6:145950112 C/G cg05347473 chr6:146136440 FBXO30 0.39 5.91 0.31 8.53e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs9322193 0.962 rs9689447 chr6:150110486 T/A cg05861140 chr6:150128134 PCMT1 -0.43 -7.05 -0.36 1.03e-11 Lung cancer; CRC cis rs17767392 0.957 rs36057816 chr14:71760546 A/T cg13720639 chr14:72061746 SIPA1L1 -0.53 -6.81 -0.35 4.7e-11 Mitral valve prolapse; CRC trans rs2243480 1.000 rs58669269 chr7:65951953 T/C cg10756647 chr7:56101905 PSPH 0.74 7.52 0.38 5.22e-13 Diabetic kidney disease; CRC cis rs524281 0.861 rs6591208 chr11:65949689 A/C cg16950941 chr11:66035639 RAB1B -0.6 -7.43 -0.38 9.29e-13 Electroencephalogram traits; CRC cis rs1129187 0.902 rs10948059 chr6:42928461 C/T cg05552183 chr6:42928497 GNMT 0.69 11.58 0.54 3e-26 Alzheimer's disease in APOE e4+ carriers; CRC cis rs12431939 0.779 rs3007081 chr14:51645492 G/A cg23942311 chr14:51606299 NA 0.49 6.81 0.35 4.68e-11 Cancer; CRC cis rs6032067 0.929 rs17333381 chr20:43804919 C/T cg10761708 chr20:43804764 PI3 0.5 5.8 0.3 1.54e-8 Blood protein levels; CRC trans rs6550704 0.687 rs9865314 chr3:22634337 A/G cg05951993 chr19:49496864 GYS1;RUVBL2 -0.41 -6.18 -0.32 1.85e-9 Daytime sleep phenotypes; CRC cis rs7224685 0.501 rs4790169 chr17:4022665 G/A cg10724054 chr17:3904396 NA 0.47 7.57 0.39 3.75e-13 Type 2 diabetes; CRC cis rs6952808 0.656 rs73048919 chr7:2103637 C/A cg04267008 chr7:1944627 MAD1L1 -0.72 -9.86 -0.48 2.93e-20 Bipolar disorder and schizophrenia; CRC cis rs1005277 0.579 rs2474587 chr10:38420666 C/T cg25517755 chr10:38738941 LOC399744 -0.42 -6.06 -0.32 3.79e-9 Extrinsic epigenetic age acceleration; CRC cis rs847577 0.609 rs6465658 chr7:97816638 C/G cg21770322 chr7:97807741 LMTK2 0.87 19.45 0.73 1.29e-56 Breast cancer; CRC cis rs2985684 0.948 rs12886130 chr14:50082753 T/C cg04989706 chr14:50066350 PPIL5 -0.6 -8.25 -0.41 3.95e-15 Carotid intima media thickness; CRC cis rs4665809 0.887 rs2384324 chr2:26354239 A/G cg25036284 chr2:26402008 FAM59B -0.47 -5.86 -0.31 1.15e-8 Gut microbiome composition (summer); CRC cis rs4237845 0.611 rs4760347 chr12:58346868 T/C cg00677455 chr12:58241039 CTDSP2 0.4 5.67 0.3 3.08e-8 Intelligence (multi-trait analysis); CRC cis rs7539542 0.556 rs6692075 chr1:202881302 C/T cg19681188 chr1:202830198 LOC148709 0.45 6.54 0.34 2.37e-10 Mean platelet volume; CRC cis rs7412746 0.658 rs11589458 chr1:150792616 A/G cg17724175 chr1:150552817 MCL1 0.5 7.46 0.38 7.75e-13 Melanoma; CRC cis rs7811142 1.000 rs11559117 chr7:100076614 A/G cg00814883 chr7:100076585 TSC22D4 -0.74 -9.4 -0.46 9.54e-19 Platelet count; CRC cis rs6951245 1.000 rs78185558 chr7:1090183 G/C cg26224354 chr7:1096374 C7orf50;GPR146 -0.81 -10.53 -0.5 1.59e-22 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs8078723 1.000 rs2227336 chr17:38174855 T/G cg17344932 chr17:38183730 MED24;SNORD124 -0.46 -7.19 -0.37 4.47e-12 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); CRC cis rs8031584 0.736 rs11635775 chr15:31160640 A/G cg08704250 chr15:31115839 NA -0.57 -9.59 -0.47 2.24e-19 Huntington's disease progression; CRC cis rs888194 0.677 rs10850139 chr12:109875934 A/C cg19025524 chr12:109796872 NA -0.4 -5.81 -0.3 1.5e-8 Neuroticism; CRC cis rs10504229 0.639 rs2291764 chr8:58142943 A/C cg11062466 chr8:58055876 NA 0.57 6.99 0.36 1.57e-11 Developmental language disorder (linguistic errors); CRC cis rs9326248 0.574 rs1263173 chr11:116681008 C/T cg11861562 chr11:117069780 TAGLN 0.27 6.16 0.32 2.08e-9 Blood protein levels; CRC trans rs7395662 0.591 rs11039766 chr11:48488715 T/C cg00717180 chr2:96193071 NA -0.39 -6.4 -0.33 5.23e-10 HDL cholesterol; CRC cis rs2032447 0.869 rs2230655 chr6:26033506 A/G cg18357526 chr6:26021779 HIST1H4A -0.81 -12.54 -0.57 9.37e-30 Intelligence (multi-trait analysis); CRC cis rs9733 0.596 rs2275236 chr1:150669952 A/G cg10589385 chr1:150898437 SETDB1 -0.29 -6.05 -0.32 3.84e-9 Tonsillectomy; CRC cis rs11608355 0.545 rs2302707 chr12:109893797 G/A cg05360138 chr12:110035743 NA 0.77 8.7 0.43 1.65e-16 Neuroticism; CRC cis rs6088813 1.000 rs6088816 chr20:33982435 G/A cg14752227 chr20:34000481 UQCC -0.37 -5.74 -0.3 2.12e-8 Height; CRC cis rs11605275 1.000 rs74809393 chr11:20031520 C/A cg14835545 chr11:20032148 NAV2 -0.83 -5.64 -0.3 3.57e-8 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs789859 1.000 rs789862 chr3:194404522 C/T cg02072170 chr3:194406190 FAM43A -0.44 -7.61 -0.39 2.85e-13 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; CRC cis rs6504249 0.893 rs2521827 chr17:62692728 T/G cg02598441 chr17:62777298 LOC146880 -0.52 -6.71 -0.35 8.51e-11 Joint mobility (Beighton score); CRC cis rs10464366 1.000 rs10464366 chr7:39121500 A/T cg18850127 chr7:39170497 POU6F2 -0.47 -5.93 -0.31 7.81e-9 IgG glycosylation; CRC cis rs10992471 0.603 rs10992349 chr9:95233887 T/C cg14631576 chr9:95140430 CENPP -0.41 -7.35 -0.38 1.61e-12 Visceral adipose tissue/subcutaneous adipose tissue ratio; CRC cis rs597539 0.652 rs10792001 chr11:68637737 G/C cg06028808 chr11:68637592 NA 0.41 6.67 0.35 1.07e-10 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC trans rs9329221 1.000 rs9329221 chr8:10240202 G/T cg16141378 chr3:129829833 LOC729375 -0.42 -6.38 -0.33 6.18e-10 Neuroticism; CRC cis rs6964587 1.000 rs7797834 chr7:91743150 C/T cg17063962 chr7:91808500 NA -0.81 -14.37 -0.62 1.09e-36 Breast cancer; CRC cis rs6502050 0.723 rs11650633 chr17:80083807 T/C cg02741985 chr17:80059408 CCDC57 -0.44 -7.35 -0.38 1.59e-12 Life satisfaction; CRC cis rs28386778 0.933 rs2665801 chr17:61952100 C/T cg06873352 chr17:61820015 STRADA 0.77 14.38 0.62 9.97e-37 Prudent dietary pattern; CRC cis rs3617 0.652 rs7630552 chr3:52891570 G/C cg07507251 chr3:52567010 NT5DC2 -0.41 -6.32 -0.33 8.5e-10 Red blood cell count;Autism spectrum disorder or schizophrenia; CRC cis rs6582630 0.537 rs2204006 chr12:38407098 A/G cg26384229 chr12:38710491 ALG10B 0.69 9.74 0.47 7.27e-20 Drug-induced liver injury (flucloxacillin); CRC cis rs9527 0.545 rs35756290 chr10:104585572 G/A cg15744005 chr10:104629667 AS3MT -0.35 -6.32 -0.33 8.74e-10 Arsenic metabolism; CRC cis rs10504229 0.679 rs56040464 chr8:58131603 G/A cg22535103 chr8:58192502 C8orf71 -0.7 -9.34 -0.46 1.47e-18 Developmental language disorder (linguistic errors); CRC cis rs7618915 0.501 rs3755798 chr3:52741160 G/A cg11645453 chr3:52864694 ITIH4 0.36 6.48 0.34 3.26e-10 Bipolar disorder; CRC cis rs853679 0.550 rs34477097 chr6:28197186 C/T cg02683197 chr6:28174875 NA 0.71 9.08 0.45 1.06e-17 Depression; CRC cis rs9322193 0.923 rs4354168 chr6:150017778 C/T cg00933542 chr6:150070202 PCMT1 0.3 6.26 0.33 1.17e-9 Lung cancer; CRC cis rs1878931 0.582 rs9937267 chr16:3421073 C/T cg26668626 chr16:3451006 ZNF174;ZNF434 0.57 7.08 0.36 8.83e-12 Body mass index (adult); CRC cis rs2836974 0.897 rs11911112 chr21:40528346 A/C cg17971929 chr21:40555470 PSMG1 0.83 12.88 0.58 5.05e-31 Cognitive function; CRC cis rs1003719 0.613 rs9978998 chr21:38535848 T/C cg10648535 chr21:38446584 PIGP;TTC3 -0.48 -6.67 -0.35 1.08e-10 Eye color traits; CRC cis rs2239547 0.603 rs6789219 chr3:53098938 C/G cg15147215 chr3:52552868 STAB1 -0.42 -5.84 -0.31 1.25e-8 Schizophrenia; CRC cis rs8072100 0.840 rs9900360 chr17:45491979 C/T cg08085267 chr17:45401833 C17orf57 -0.66 -10.75 -0.51 2.65e-23 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs10504229 1.000 rs116444534 chr8:58181915 A/G cg01721255 chr8:58191610 C8orf71 0.46 5.92 0.31 8.21e-9 Developmental language disorder (linguistic errors); CRC cis rs1552244 0.882 rs3755783 chr3:10029289 A/G cg10729496 chr3:10149963 C3orf24 0.5 6.13 0.32 2.53e-9 Alzheimer's disease; CRC cis rs9818758 0.607 rs13087930 chr3:48961726 A/G cg07636037 chr3:49044803 WDR6 -0.83 -6.8 -0.35 4.84e-11 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg03695666 chr19:38210224 ZNF607 0.36 5.98 0.31 5.71e-9 Obesity-related traits; CRC trans rs2727020 0.658 rs7120136 chr11:49384358 A/C cg03929089 chr4:120376271 NA -0.88 -16.15 -0.66 1.27e-43 Coronary artery disease; CRC cis rs10489202 0.657 rs3767478 chr1:168069626 G/A cg24449463 chr1:168025552 DCAF6 -0.52 -7.2 -0.37 4.18e-12 Schizophrenia; CRC trans rs2228479 1.000 rs62052186 chr16:89969567 A/T cg21302420 chr1:112162376 RAP1A 0.78 6.95 0.36 2.02e-11 Skin colour saturation; CRC cis rs4819052 0.807 rs7283915 chr21:46671288 T/C cg19498844 chr21:46707878 POFUT2;LOC642852 0.73 10.63 0.51 7.1e-23 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs644799 0.965 rs687529 chr11:95545587 T/A cg25622487 chr11:95524042 FAM76B;CEP57 0.76 11.87 0.55 2.62e-27 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs4819052 0.851 rs2838828 chr21:46663423 A/G cg19498844 chr21:46707878 POFUT2;LOC642852 0.77 11.18 0.52 8.01e-25 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs7613875 0.620 rs13079006 chr3:49996924 G/T cg24308560 chr3:49941425 MST1R -0.42 -6.51 -0.34 2.78e-10 Body mass index; CRC cis rs11148252 0.740 rs7983971 chr13:52790700 C/T cg00495681 chr13:53174319 NA 0.56 8.08 0.41 1.22e-14 Lewy body disease; CRC cis rs11148252 0.514 rs9526843 chr13:52730056 C/T cg02158880 chr13:53174818 NA 0.39 5.62 0.3 4.11e-8 Lewy body disease; CRC cis rs611744 0.647 rs2594358 chr8:109256018 A/G cg21045802 chr8:109455806 TTC35 0.4 6.29 0.33 9.87e-10 Dupuytren's disease; CRC cis rs372883 0.648 rs2832296 chr21:30741454 C/T cg08807101 chr21:30365312 RNF160 -0.55 -7.73 -0.39 1.35e-13 Pancreatic cancer; CRC cis rs28386778 0.863 rs3760256 chr17:61821161 A/G cg25654072 chr17:61904446 PSMC5;FTSJ3 0.71 11.13 0.52 1.23e-24 Prudent dietary pattern; CRC cis rs8067545 0.616 rs203465 chr17:19810720 T/G cg04132472 chr17:19861366 AKAP10 0.45 7.15 0.37 5.54e-12 Schizophrenia; CRC cis rs910316 0.523 rs4026175 chr14:75502240 C/A cg11812906 chr14:75593930 NEK9 0.5 7.04 0.36 1.1e-11 Height; CRC cis rs861020 1.000 rs622832 chr1:209974232 A/C cg05527609 chr1:210001259 C1orf107 0.87 11.27 0.53 3.91e-25 Orofacial clefts; CRC cis rs7216064 0.861 rs12449312 chr17:65829358 A/C cg12091567 chr17:66097778 LOC651250 -0.66 -7.97 -0.4 2.6e-14 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CRC trans rs4942242 0.640 rs9533571 chr13:44230136 C/T cg19169023 chr15:41853346 TYRO3 -0.58 -8.78 -0.44 8.85e-17 Response to tocilizumab in rheumatoid arthritis; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg06742493 chr19:13056745 RAD23A -0.4 -6.04 -0.32 4.13e-9 Myopia (pathological); CRC cis rs73206853 0.841 rs17619763 chr12:110645829 C/T cg12870014 chr12:110450643 ANKRD13A 0.79 7.76 0.39 1.06e-13 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC cis rs9611565 0.503 rs5996062 chr22:42167464 C/G cg06481639 chr22:41940642 POLR3H 0.56 6.19 0.32 1.75e-9 Vitiligo; CRC cis rs11585357 0.895 rs72633812 chr1:17623140 T/C cg08277548 chr1:17600880 PADI3 -0.91 -11.62 -0.54 2.12e-26 Hair shape; CRC cis rs4665809 1.000 rs4665308 chr2:26330514 C/A cg22920501 chr2:26401640 FAM59B -0.52 -7.15 -0.37 5.68e-12 Gut microbiome composition (summer); CRC cis rs10504229 0.728 rs1495867 chr8:58155500 G/T cg22535103 chr8:58192502 C8orf71 -0.68 -8.37 -0.42 1.72e-15 Developmental language disorder (linguistic errors); CRC cis rs1865760 0.625 rs9393681 chr6:26008260 A/G cg16482183 chr6:26056742 HIST1H1C 0.52 7.74 0.39 1.22e-13 Height; CRC cis rs561341 1.000 rs117979353 chr17:30272866 A/G cg00745463 chr17:30367425 LRRC37B -0.89 -9.78 -0.47 5.21e-20 Hip circumference adjusted for BMI; CRC cis rs951366 1.000 rs4951261 chr1:205717823 A/C cg17178900 chr1:205818956 PM20D1 -0.39 -5.62 -0.3 4.1e-8 Menarche (age at onset); CRC cis rs10191773 0.589 rs72831638 chr2:112949212 C/G cg04979063 chr2:113191202 RGPD5;RGPD8 0.65 5.74 0.3 2.15e-8 Yeast infection; CRC cis rs853679 0.517 rs9368552 chr6:28068426 A/G cg12273811 chr6:28175739 NA 0.73 9.31 0.46 1.82e-18 Depression; CRC cis rs1451375 0.756 rs11761683 chr7:50542879 C/T cg18232548 chr7:50535776 DDC -0.57 -8.21 -0.41 4.99e-15 Malaria; CRC cis rs1552244 0.572 rs3894321 chr3:10168892 A/C cg00166722 chr3:10149974 C3orf24 0.67 7.94 0.4 3.17e-14 Alzheimer's disease; CRC trans rs9784649 1.000 rs55924805 chr5:24999756 C/T cg08600765 chr20:34638493 LOC647979 -0.58 -6.58 -0.34 1.86e-10 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs1401999 1.000 rs2872249 chr3:183636273 T/A cg01324343 chr3:183735012 ABCC5 0.81 14.76 0.63 3.54e-38 Anterior chamber depth; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg10353612 chr8:33330866 FUT10 0.39 5.98 0.31 5.9e-9 Intelligence (multi-trait analysis); CRC trans rs2303319 0.504 rs12469302 chr2:162433831 G/T cg12500891 chr11:57225987 NA -0.67 -5.98 -0.31 5.67e-9 Cognitive function; CRC cis rs400736 0.602 rs4573544 chr1:8165247 C/T cg25007680 chr1:8021821 PARK7 -0.5 -6.69 -0.35 9.35e-11 Response to antidepressants and depression; CRC trans rs4942242 1.000 rs1105856 chr13:44227067 G/T cg26741380 chr15:41871084 TYRO3 0.41 6.07 0.32 3.51e-9 Response to tocilizumab in rheumatoid arthritis; CRC cis rs2836974 0.836 rs8129355 chr21:40579869 A/G cg11890956 chr21:40555474 PSMG1 1.09 18.58 0.72 3.25e-53 Cognitive function; CRC cis rs4713118 0.786 rs200503 chr6:27785882 A/G cg03623178 chr6:28175578 NA 0.73 9.19 0.45 4.45e-18 Parkinson's disease; CRC cis rs7552404 1.000 rs4949875 chr1:76173080 G/A cg03433033 chr1:76189801 ACADM 0.81 11.17 0.52 8.58e-25 Blood metabolite levels;Acylcarnitine levels; CRC cis rs9398803 0.865 rs4422634 chr6:126806676 A/G cg19875578 chr6:126661172 C6orf173 0.43 5.92 0.31 7.92e-9 Male-pattern baldness; CRC cis rs4555082 0.957 rs2816629 chr14:105737261 G/A cg10792982 chr14:105748885 BRF1 0.36 6.21 0.32 1.61e-9 Mean platelet volume;Platelet distribution width; CRC cis rs763121 0.853 rs2267393 chr22:39101619 G/C cg06544989 chr22:39130855 UNC84B 0.48 7.6 0.39 3.18e-13 Menopause (age at onset); CRC cis rs1538970 0.924 rs6657284 chr1:45879088 T/C cg05343316 chr1:45956843 TESK2 0.76 10.12 0.49 3.8e-21 Platelet count; CRC cis rs1799949 0.965 rs34633610 chr17:41419385 A/G cg19454999 chr17:41278357 BRCA1;NBR2 0.53 8.06 0.41 1.47e-14 Menopause (age at onset); CRC cis rs11098499 0.657 rs9996569 chr4:120299004 G/C cg09307838 chr4:120376055 NA 0.71 10.93 0.52 6.41e-24 Corneal astigmatism; CRC cis rs7312933 0.533 rs17551006 chr12:42848738 G/C cg19980929 chr12:42632907 YAF2 0.4 6.11 0.32 2.82e-9 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CRC cis rs7618915 0.547 rs11177 chr3:52721305 G/A cg18404041 chr3:52824283 ITIH1 -0.44 -9.02 -0.45 1.62e-17 Bipolar disorder; CRC cis rs5750830 0.649 rs4384886 chr22:39793766 C/T cg25956985 chr22:39795188 MAP3K7IP1 -0.42 -6.2 -0.32 1.69e-9 Intelligence (multi-trait analysis); CRC cis rs870825 0.616 rs2141257 chr4:185609463 C/T cg04058563 chr4:185651563 MLF1IP -0.76 -8.44 -0.42 1.01e-15 Blood protein levels; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg03674076 chr20:524243 CSNK2A1 0.38 5.96 0.31 6.41e-9 Liver disease severity in Alagille syndrome; CRC cis rs972578 0.967 rs5759082 chr22:43401079 C/T cg01576275 chr22:43409880 NA -0.48 -7.85 -0.4 5.83e-14 Mean platelet volume; CRC cis rs11677416 1.000 rs1878321 chr2:113544434 A/G cg27083787 chr2:113543245 IL1A 0.42 5.86 0.31 1.12e-8 Response to antipsychotic treatment in schizophrenia (working memory); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg23249942 chr5:109027037 MAN2A1 0.42 6.02 0.31 4.78e-9 Response to antipsychotic treatment; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg26646878 chr17:900222 TIMM22 0.47 7.18 0.37 4.64e-12 Intelligence (multi-trait analysis); CRC cis rs7843479 0.601 rs10109521 chr8:21829948 G/A cg17168535 chr8:21777572 XPO7 0.59 9.76 0.47 6.44e-20 Mean corpuscular volume; CRC cis rs172166 0.637 rs1071893 chr6:28167635 G/C cg15845792 chr6:28175446 NA 0.86 13.56 0.6 1.46e-33 Cardiac Troponin-T levels; CRC trans rs6601450 0.579 rs11775625 chr8:10272439 C/T cg06636001 chr8:8085503 FLJ10661 0.41 6.44 0.33 4.13e-10 Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC cis rs853679 0.517 rs9368552 chr6:28068426 A/G cg12172441 chr6:28176163 NA 0.62 7.33 0.37 1.76e-12 Depression; CRC cis rs6997458 0.742 rs13269441 chr8:86330635 G/C cg21346043 chr8:86351067 CA3 -0.27 -5.89 -0.31 9.69e-9 Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; CRC cis rs9467711 0.606 rs9379855 chr6:26364930 C/T cg14345882 chr6:26364793 BTN3A2 -0.68 -5.89 -0.31 9.3e-9 Autism spectrum disorder or schizophrenia; CRC cis rs9549328 0.642 rs2993343 chr13:113616844 C/G cg25790453 chr13:113633590 MCF2L 0.44 7.51 0.38 5.45e-13 Systolic blood pressure; CRC cis rs4731207 0.564 rs10954057 chr7:124613938 T/G cg23710748 chr7:124431027 NA -0.39 -6.25 -0.33 1.29e-9 Cutaneous malignant melanoma; CRC cis rs9549328 0.731 rs7983602 chr13:113620482 A/G cg20742385 chr13:113633654 MCF2L -0.66 -11.58 -0.54 3.06e-26 Systolic blood pressure; CRC cis rs2836950 0.565 rs2836926 chr21:40536790 G/A cg11644478 chr21:40555479 PSMG1 -0.5 -7.64 -0.39 2.46e-13 Menarche (age at onset); CRC cis rs2370759 1.000 rs16933177 chr10:32565705 G/A cg01819863 chr10:32635814 EPC1 1.08 12.39 0.56 3.42e-29 Sexual dysfunction (female); CRC cis rs9796 0.624 rs9920619 chr15:41318845 A/G cg18705301 chr15:41695430 NDUFAF1 -0.37 -6.1 -0.32 2.96e-9 Menopause (age at onset); CRC cis rs7524258 0.900 rs7544004 chr1:7314529 A/C cg07173049 chr1:7289937 CAMTA1 0.45 7.5 0.38 6.1e-13 Tourette's syndrome or obsessive-compulsive disorder; CRC cis rs4689388 0.926 rs11725494 chr4:6293855 C/T cg00701064 chr4:6280414 WFS1 0.76 13.44 0.6 3.97e-33 Type 2 diabetes and other traits;Type 2 diabetes; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg19545348 chr1:211434133 RCOR3 0.47 6.6 0.34 1.62e-10 Response to antipsychotic treatment; CRC cis rs12142240 0.698 rs6697123 chr1:46811310 A/C cg00530320 chr1:46809349 NSUN4 0.58 7.8 0.4 8.18e-14 Menopause (age at onset); CRC cis rs782590 0.935 rs2627779 chr2:55892356 A/G cg18811423 chr2:55921094 PNPT1 0.8 14.56 0.63 2.12e-37 Metabolic syndrome; CRC cis rs9400239 0.622 rs1159806 chr6:109006838 A/T cg11073813 chr6:109029018 NA -0.39 -6.11 -0.32 2.75e-9 Waist circumference;Body mass index;BMI (adjusted for smoking behaviour); CRC cis rs3008870 1.000 rs2815351 chr1:67477980 A/G cg08660285 chr1:67390436 MIER1;WDR78 1.01 13.44 0.6 3.86e-33 Lymphocyte percentage of white cells; CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg06836181 chr2:64995545 NA -0.56 -6.91 -0.36 2.54e-11 Diisocyanate-induced asthma; CRC cis rs1832871 0.672 rs6899322 chr6:158753669 G/T cg07165851 chr6:158734300 TULP4 0.62 7.81 0.4 7.6e-14 Height; CRC cis rs62432291 0.681 rs2932987 chr6:159655673 C/G cg14500486 chr6:159655392 FNDC1 0.79 10.65 0.51 5.77e-23 Joint mobility (Beighton score); CRC cis rs2635047 1.000 rs2635049 chr18:44687303 C/T cg23996704 chr18:44553084 KATNAL2 0.28 5.85 0.31 1.21e-8 Educational attainment; CRC cis rs7811142 1.000 rs74460138 chr7:100027339 C/G cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.74 10.2 0.49 2.05e-21 Platelet count; CRC cis rs10504229 0.683 rs11775506 chr8:58133639 G/T cg04204079 chr8:58130323 NA -0.45 -5.75 -0.3 2.06e-8 Developmental language disorder (linguistic errors); CRC cis rs1707322 0.638 rs1416706 chr1:46602844 G/A cg06784218 chr1:46089804 CCDC17 -0.5 -8.04 -0.41 1.63e-14 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg18158177 chr1:39492193 NDUFS5 0.44 6.28 0.33 1.05e-9 Response to antipsychotic treatment; CRC cis rs875971 0.522 rs2949690 chr7:65483242 C/T cg18876405 chr7:65276391 NA -0.67 -12.17 -0.56 2.24e-28 Aortic root size; CRC trans rs10838798 0.504 rs10838852 chr11:48286256 C/T cg21153622 chr11:89784906 NA -0.5 -8.3 -0.42 2.65e-15 Height; CRC cis rs3889199 1.000 rs34370185 chr1:59656909 G/T cg25881383 chr1:59680599 NA -0.37 -5.9 -0.31 9e-9 Pulse pressure; CRC cis rs896854 0.517 rs9643353 chr8:95957063 A/G cg16049864 chr8:95962084 TP53INP1 0.45 7.28 0.37 2.48e-12 Type 2 diabetes; CRC cis rs9372498 0.536 rs9489394 chr6:118758234 T/C cg18833306 chr6:118973337 C6orf204 0.44 5.74 0.3 2.12e-8 Diastolic blood pressure; CRC cis rs9818941 1.000 rs9845687 chr3:157682536 T/C cg08654915 chr3:157813417 NA -0.32 -5.92 -0.31 8.11e-9 Height; CRC cis rs2012796 0.957 rs7151434 chr14:81819468 A/G cg02996355 chr14:81879375 NA 0.49 7.27 0.37 2.6e-12 Night sleep phenotypes; CRC cis rs7666738 0.830 rs10049627 chr4:99025272 A/C cg05340658 chr4:99064831 C4orf37 0.61 9.42 0.46 8.23e-19 Colonoscopy-negative controls vs population controls; CRC cis rs28386778 0.797 rs4968664 chr17:61851366 C/G cg06873352 chr17:61820015 STRADA 0.76 14.31 0.62 1.87e-36 Prudent dietary pattern; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg23233605 chr9:130548199 CDK9 0.45 6.95 0.36 2e-11 Liver disease severity in Alagille syndrome; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg04215179 chr7:23719682 C7orf46 -0.4 -5.97 -0.31 6.11e-9 Myopia (pathological); CRC cis rs6502050 0.842 rs7218075 chr17:80076808 C/G cg09264619 chr17:80180166 NA 0.36 5.92 0.31 8.22e-9 Life satisfaction; CRC cis rs801193 0.660 rs1962050 chr7:66240008 C/T cg18912574 chr7:65842487 NCRNA00174 -0.36 -6.01 -0.31 4.96e-9 Aortic root size; CRC cis rs10905065 0.930 rs10795485 chr10:5755047 T/C cg11519256 chr10:5708881 ASB13 0.43 6.13 0.32 2.53e-9 Menopause (age at onset); CRC cis rs4253772 0.550 rs12165597 chr22:46705584 A/G cg03482458 chr22:46692211 CN5H6.4;GTSE1 0.5 6.15 0.32 2.26e-9 LDL cholesterol;Cholesterol, total; CRC cis rs9322193 0.847 rs9383844 chr6:150037404 T/C cg00933542 chr6:150070202 PCMT1 0.31 6.48 0.34 3.35e-10 Lung cancer; CRC cis rs9649213 0.593 rs3779194 chr7:98010277 A/G cg21770322 chr7:97807741 LMTK2 0.52 8.58 0.43 3.78e-16 Prostate cancer (SNP x SNP interaction); CRC cis rs12477438 0.798 rs6705821 chr2:99602832 T/C cg14399236 chr2:99771627 LIPT1;TSGA10 -0.74 -10.37 -0.5 5.51e-22 Chronic sinus infection; CRC cis rs62244186 0.566 rs55852922 chr3:44826188 A/G cg11003573 chr3:44754125 ZNF502 -0.33 -5.64 -0.3 3.7e-8 Depressive symptoms; CRC cis rs7215564 0.908 rs59254087 chr17:78665278 A/C cg09596252 chr17:78655493 RPTOR 0.55 6.13 0.32 2.57e-9 Myopia (pathological); CRC cis rs1545257 0.537 rs2702089 chr2:24643291 A/G cg06627628 chr2:24431161 ITSN2 0.45 6.55 0.34 2.2e-10 Sjögren's syndrome; CRC cis rs7727544 1.000 rs7727544 chr5:131590534 C/T cg20512303 chr5:131592959 PDLIM4 0.3 5.79 0.3 1.68e-8 Blood metabolite levels; CRC cis rs12476592 0.571 rs1446565 chr2:63731575 T/C cg10828910 chr2:63850056 LOC388955 0.49 6.08 0.32 3.33e-9 Childhood ear infection; CRC cis rs1941023 0.584 rs2241921 chr11:60164302 C/T cg08716584 chr11:60157161 MS4A7 -0.56 -9.52 -0.46 3.75e-19 Congenital heart disease (maternal effect); CRC cis rs875971 0.545 rs73378304 chr7:65640747 G/A cg05627663 chr7:65219948 SNORA22;CCT6P1 0.56 7.63 0.39 2.63e-13 Aortic root size; CRC cis rs1728785 1.000 rs1615609 chr16:68596401 C/A cg02972257 chr16:68554789 NA -0.6 -7.54 -0.38 4.71e-13 Ulcerative colitis; CRC trans rs1864585 0.520 rs9650659 chr8:10667765 G/T cg26278703 chr11:58910052 FAM111A 0.51 6.07 0.32 3.55e-9 Neutrophil percentage of white cells;Lymphocyte percentage of white cells; CRC trans rs7267979 0.903 rs6115101 chr20:25229564 C/A cg17903999 chr18:56338584 MALT1 -0.4 -6.39 -0.33 5.79e-10 Liver enzyme levels (alkaline phosphatase); CRC cis rs704795 0.902 rs11887784 chr2:27679919 A/G cg12000995 chr2:27665139 KRTCAP3 -0.32 -6.43 -0.33 4.49e-10 Menopause (age at onset); CRC cis rs10504229 0.683 rs7820559 chr8:58142662 C/T cg02725872 chr8:58115012 NA -0.64 -11.4 -0.53 1.31e-25 Developmental language disorder (linguistic errors); CRC cis rs2811415 0.597 rs2033445 chr3:127730507 A/G cg13719885 chr3:127795394 NA -0.39 -5.93 -0.31 7.85e-9 Lung function (FEV1/FVC); CRC cis rs7618915 0.571 rs67539070 chr3:52711974 T/C cg10802521 chr3:52805072 NEK4 -0.59 -9.02 -0.45 1.55e-17 Bipolar disorder; CRC cis rs950776 0.518 rs4887063 chr15:78839715 C/T cg06917634 chr15:78832804 PSMA4 -0.63 -10.46 -0.5 2.67e-22 Sudden cardiac arrest; CRC cis rs908922 0.676 rs486283 chr1:152525957 A/G cg09873164 chr1:152488093 CRCT1 0.36 6.13 0.32 2.48e-9 Hair morphology; CRC cis rs1799949 0.930 rs56729776 chr17:41422131 C/T cg25072359 chr17:41440525 NA 0.45 6.61 0.34 1.53e-10 Menopause (age at onset); CRC cis rs2072499 0.966 rs2853641 chr1:156181770 A/G cg25208724 chr1:156163844 SLC25A44 1.06 24.4 0.8 8.27e-76 Testicular germ cell tumor; CRC cis rs2257205 0.667 rs9889631 chr17:56630359 G/T cg25885038 chr17:56607967 SEPT4 -0.56 -6.21 -0.32 1.55e-9 Pancreatic cancer; CRC cis rs1728785 1.000 rs1645928 chr16:68590610 G/T cg02972257 chr16:68554789 NA -0.65 -7.67 -0.39 1.91e-13 Ulcerative colitis; CRC trans rs2470578 0.716 rs2733514 chr3:17323931 A/G cg05802477 chr12:132629385 DDX51;NOC4L -0.41 -6.03 -0.32 4.34e-9 Schizophrenia; CRC cis rs1348850 0.514 rs4893974 chr2:178497026 A/G cg22681709 chr2:178499509 PDE11A -0.36 -5.62 -0.3 4.09e-8 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs13382862 0.895 rs2289082 chr2:20881958 A/T cg09074113 chr2:20870087 GDF7 0.31 6.16 0.32 2.09e-9 Abdominal aortic aneurysm; CRC cis rs776905 0.598 rs6042 chr13:113770068 C/T cg09069900 chr13:113776964 F10 -0.44 -6.98 -0.36 1.63e-11 Blood protein levels; CRC cis rs3126085 1.000 rs11485508 chr1:152253167 T/G cg09127314 chr1:152161683 NA 0.45 5.86 0.31 1.14e-8 Atopic dermatitis; CRC cis rs4692589 0.802 rs1480542 chr4:170953614 C/T cg19918862 chr4:170955249 NA 0.5 7.94 0.4 3.33e-14 Anxiety disorder; CRC trans rs11098499 0.566 rs7664440 chr4:120578540 A/G cg25214090 chr10:38739885 LOC399744 0.57 8.66 0.43 2.13e-16 Corneal astigmatism; CRC cis rs2304069 0.545 rs6866616 chr5:149415401 A/G cg22760475 chr5:149380129 HMGXB3;TIGD6 0.45 6.51 0.34 2.82e-10 HIV-1 control; CRC cis rs7618915 0.508 rs11717043 chr3:52656092 A/T cg05573699 chr3:52720067 GNL3;PBRM1 -0.46 -6.59 -0.34 1.76e-10 Bipolar disorder; CRC cis rs11764590 0.585 rs11772463 chr7:2078132 A/C cg25834613 chr7:1915315 MAD1L1 -0.46 -6.46 -0.34 3.67e-10 Neuroticism; CRC cis rs3823572 0.564 rs2953626 chr7:133657458 A/G cg03336402 chr7:133662267 EXOC4 -0.67 -10.31 -0.49 8.51e-22 Intelligence (multi-trait analysis); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg11636699 chr19:13044490 FARSA 0.39 6.24 0.33 1.34e-9 Liver disease severity in Alagille syndrome; CRC trans rs35110281 0.626 rs162368 chr21:44934767 G/A cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.41 6.47 0.34 3.54e-10 Mean corpuscular volume; CRC trans rs561341 1.000 rs561341 chr17:30316385 T/G cg20587970 chr11:113659929 NA -1.43 -20.51 -0.75 8.67e-61 Hip circumference adjusted for BMI; CRC cis rs282587 0.502 rs375741 chr13:113397794 G/C cg04656015 chr13:113407548 ATP11A 0.64 8.02 0.4 1.83e-14 Glycated hemoglobin levels; CRC cis rs9650315 0.778 rs36063247 chr8:57154653 C/T cg23139584 chr8:56987506 RPS20;SNORD54 0.56 6.13 0.32 2.57e-9 Height; CRC cis rs8180040 0.701 rs1079276 chr3:47045739 C/G cg27129171 chr3:47204927 SETD2 0.69 11.01 0.52 3.31e-24 Colorectal cancer; CRC cis rs9487051 0.700 rs7773815 chr6:109602343 A/C cg12927641 chr6:109611667 NA -0.38 -6.75 -0.35 6.72e-11 Reticulocyte fraction of red cells; CRC cis rs1552244 1.000 rs67569278 chr3:10149893 T/C cg08888203 chr3:10149979 C3orf24 0.71 9.52 0.46 3.86e-19 Alzheimer's disease; CRC cis rs6752107 1.000 rs12994971 chr2:234178453 C/T cg07618928 chr2:234183455 ATG16L1;SCARNA5 0.64 11.05 0.52 2.31e-24 Crohn's disease;Inflammatory bowel disease; CRC cis rs2836974 0.583 rs2776306 chr21:40713754 A/G cg11890956 chr21:40555474 PSMG1 0.68 10.27 0.49 1.24e-21 Cognitive function; CRC cis rs703980 1.000 rs703976 chr10:80945964 C/G cg20744163 chr10:80999841 ZMIZ1 0.31 5.76 0.3 1.94e-8 Type 2 diabetes; CRC cis rs4722166 0.568 rs1880241 chr7:22759469 A/G cg05472934 chr7:22766657 IL6 0.46 7.18 0.37 4.8e-12 Lung cancer; CRC cis rs728616 0.764 rs61859016 chr10:81852500 C/A cg05935833 chr10:81318306 SFTPA2 -0.61 -6.95 -0.36 1.97e-11 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs9942416 0.660 rs60423072 chr5:75006113 T/A cg00601450 chr5:74908170 NA 0.36 5.66 0.3 3.33e-8 Age-related disease endophenotypes; CRC cis rs6951245 0.554 rs79367977 chr7:1152657 G/A cg24642844 chr7:1081250 C7orf50 -0.47 -6.08 -0.32 3.36e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs9611565 0.592 rs5996037 chr22:41965292 A/G cg06634786 chr22:41940651 POLR3H -0.53 -6.19 -0.32 1.74e-9 Vitiligo; CRC cis rs362272 0.524 rs3129334 chr4:3368526 T/C cg16416165 chr4:3325029 RGS12 0.4 5.76 0.3 1.89e-8 Serum sulfate level; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg11287903 chr10:115613834 DCLRE1A;NHLRC2 0.46 6.0 0.31 5.18e-9 Thyroid stimulating hormone; CRC cis rs9611565 0.512 rs5758450 chr22:42141640 G/A cg17554472 chr22:41940697 POLR3H 0.55 5.66 0.3 3.31e-8 Vitiligo; CRC cis rs12760731 0.720 rs10913545 chr1:178360201 G/A cg00404053 chr1:178313656 RASAL2 0.96 10.0 0.48 9.77e-21 Obesity-related traits; CRC cis rs10883723 0.810 rs11191304 chr10:104255284 C/T cg04362960 chr10:104952993 NT5C2 -0.43 -6.1 -0.32 2.92e-9 Allergic disease (asthma, hay fever or eczema); CRC cis rs73200209 0.744 rs73200226 chr12:116637861 G/A cg01776926 chr12:116560359 MED13L -0.61 -7.0 -0.36 1.41e-11 Total body bone mineral density; CRC cis rs2440129 0.611 rs1126667 chr17:6902760 C/T cg02493798 chr17:6899577 ALOX12 -0.59 -11.16 -0.52 9.97e-25 Tonsillectomy; CRC cis rs11148252 0.500 rs342768 chr13:53208882 C/T cg02158880 chr13:53174818 NA 0.59 9.4 0.46 9.33e-19 Lewy body disease; CRC trans rs2189609 0.521 rs2526066 chr16:74037837 A/C cg18834200 chr2:172017416 TLK1 -0.44 -5.96 -0.31 6.35e-9 Energy expenditure (24h); CRC cis rs11030122 0.702 rs1349583 chr11:3972236 G/A cg18678763 chr11:4115507 RRM1 -0.48 -8.11 -0.41 1.01e-14 Mean platelet volume;Platelet distribution width; CRC cis rs73206853 0.764 rs61117387 chr12:110867725 C/A cg12870014 chr12:110450643 ANKRD13A 0.82 9.83 0.48 3.73e-20 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC cis rs6543140 0.964 rs6761350 chr2:103030776 A/G cg04239558 chr2:103089729 SLC9A4 0.37 6.39 0.33 5.69e-10 Blood protein levels; CRC cis rs7197653 0.748 rs58542611 chr16:68350219 C/T cg05110241 chr16:68378359 PRMT7 -0.71 -7.27 -0.37 2.64e-12 Magnesium levels; CRC cis rs875971 1.000 rs6460296 chr7:65895139 C/T cg18912574 chr7:65842487 NCRNA00174 0.36 6.1 0.32 2.97e-9 Aortic root size; CRC trans rs208520 0.690 rs3846808 chr6:66818604 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.05 -14.71 -0.63 5.39e-38 Exhaled nitric oxide output; CRC cis rs1524976 0.843 rs11711704 chr3:65444814 T/C cg16238336 chr3:65465873 MAGI1 -0.48 -6.92 -0.36 2.42e-11 PR interval; CRC cis rs9372498 0.505 rs72956993 chr6:118949708 A/T cg15382696 chr6:118971807 C6orf204 0.6 7.57 0.39 3.76e-13 Diastolic blood pressure; CRC cis rs9611565 0.546 rs5758430 chr22:42109844 G/T cg03806693 chr22:41940476 POLR3H 1.0 12.85 0.58 6.4e-31 Vitiligo; CRC cis rs1538970 0.781 rs12049503 chr1:46021556 G/T cg05343316 chr1:45956843 TESK2 0.76 9.94 0.48 1.61e-20 Platelet count; CRC cis rs6952808 0.723 rs4721295 chr7:2036669 G/T cg04267008 chr7:1944627 MAD1L1 0.76 11.29 0.53 3.22e-25 Bipolar disorder and schizophrenia; CRC cis rs826838 0.933 rs980573 chr12:39127811 T/C cg26384229 chr12:38710491 ALG10B -0.64 -9.67 -0.47 1.21e-19 Heart rate; CRC cis rs514406 0.547 rs377808 chr1:53190359 T/G cg08859206 chr1:53392774 SCP2 -0.42 -6.41 -0.33 5.03e-10 Monocyte count; CRC cis rs1570884 0.516 rs7334387 chr13:50172133 T/A cg02321871 chr13:50159138 RCBTB1 -0.43 -6.16 -0.32 2.18e-9 Sum basophil neutrophil counts;Sum neutrophil eosinophil counts;Neutrophil count;Myeloid white cell count;Granulocyte count; CRC cis rs736408 0.716 rs2239550 chr3:52822509 G/C cg05573699 chr3:52720067 GNL3;PBRM1 -0.46 -6.42 -0.33 4.72e-10 Bipolar disorder; CRC trans rs9395066 0.545 rs10456119 chr6:44889045 C/T cg04786201 chr1:17185605 NA 0.28 6.06 0.32 3.78e-9 Height; CRC cis rs9435341 0.965 rs12401598 chr1:107580533 C/A cg09367891 chr1:107599246 PRMT6 0.69 10.0 0.48 9.69e-21 Facial morphology (factor 21, depth of nasal alae); CRC cis rs8177253 1.000 rs8177253 chr3:133480192 A/G cg11941060 chr3:133502564 NA 0.6 10.54 0.5 1.43e-22 Iron status biomarkers; CRC cis rs9309711 0.544 rs9752130 chr2:3488502 A/G cg08493051 chr2:3487164 NA -0.43 -6.19 -0.32 1.75e-9 Neurofibrillary tangles; CRC cis rs1046896 0.520 rs8074086 chr17:80818460 A/C cg16060761 chr17:80687452 NA -0.45 -5.85 -0.31 1.17e-8 Glycated hemoglobin levels; CRC cis rs9443645 0.901 rs4147183 chr6:79557046 C/G cg11833968 chr6:79620685 NA -0.36 -6.36 -0.33 6.62e-10 Intelligence (multi-trait analysis); CRC cis rs2836974 0.831 rs34592564 chr21:40516288 G/C cg07074390 chr21:40555500 PSMG1 -0.43 -5.63 -0.3 3.95e-8 Cognitive function; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg17434043 chr11:2907123 CDKN1C 0.53 7.5 0.38 5.84e-13 Response to antipsychotic treatment; CRC cis rs6988985 0.703 rs7016594 chr8:143950352 G/A cg10324643 chr8:143916377 GML 0.35 5.7 0.3 2.69e-8 Plasma androstenedione levels in resected early stage-receptor positive breast cancer; CRC cis rs939574 0.512 rs55908154 chr2:220145960 G/C cg00496455 chr2:220118770 TUBA4A;TUBA4B 0.54 6.2 0.32 1.67e-9 Platelet distribution width; CRC cis rs274567 0.501 rs272856 chr5:131687081 G/C cg02033258 chr5:131593261 PDLIM4 0.39 6.37 0.33 6.32e-10 Blood metabolite levels; CRC cis rs910187 0.631 rs2228 chr20:45809941 G/A cg27589058 chr20:45804311 EYA2 -0.41 -7.74 -0.39 1.24e-13 Migraine; CRC cis rs9467711 0.591 rs13214280 chr6:26008620 C/T cg08501292 chr6:25962987 TRIM38 0.85 7.53 0.38 4.89e-13 Autism spectrum disorder or schizophrenia; CRC cis rs501120 0.564 rs1509931 chr10:44682080 C/T cg09554077 chr10:44749378 NA 0.55 7.67 0.39 1.95e-13 Coronary artery disease;Coronary heart disease; CRC cis rs67311347 0.544 rs13098483 chr3:40342743 G/C cg09455208 chr3:40491958 NA 0.32 6.43 0.33 4.38e-10 Renal cell carcinoma; CRC cis rs2811415 0.597 rs9813812 chr3:127791936 G/T cg13719885 chr3:127795394 NA -0.39 -5.96 -0.31 6.34e-9 Lung function (FEV1/FVC); CRC cis rs2836633 0.895 rs2836598 chr21:40024758 C/G cg12884169 chr21:40033163 ERG 0.43 10.1 0.49 4.56e-21 Coronary artery disease; CRC cis rs4731207 0.596 rs11767737 chr7:124637905 A/G cg23710748 chr7:124431027 NA -0.39 -6.27 -0.33 1.15e-9 Cutaneous malignant melanoma; CRC trans rs1005277 0.505 rs10827836 chr10:38215441 A/G cg23533926 chr12:111358616 MYL2 0.44 6.43 0.33 4.44e-10 Extrinsic epigenetic age acceleration; CRC cis rs6460942 0.915 rs17444141 chr7:12460971 T/G cg20607287 chr7:12443886 VWDE -0.66 -6.93 -0.36 2.17e-11 Coronary artery disease; CRC cis rs2346177 0.542 rs718849 chr2:46698116 G/A cg26688816 chr2:46740690 ATP6V1E2 -0.63 -9.56 -0.47 2.78e-19 HDL cholesterol; CRC cis rs910187 0.641 rs3186647 chr20:45817067 T/C cg27589058 chr20:45804311 EYA2 -0.4 -7.51 -0.38 5.45e-13 Migraine; CRC cis rs7843479 0.601 rs2002941 chr8:21834366 A/C cg16476235 chr8:21771668 DOK2 0.4 6.85 0.35 3.55e-11 Mean corpuscular volume; CRC cis rs4336470 0.547 rs9499924 chr6:105142638 C/G cg02098413 chr6:105308735 HACE1 -0.43 -8.38 -0.42 1.53e-15 Neuroblastoma; CRC trans rs2303319 0.504 rs62188988 chr2:162531068 T/C cg22407090 chr2:61765448 XPO1 -0.67 -6.02 -0.31 4.75e-9 Cognitive function; CRC cis rs9372498 0.536 rs9489433 chr6:118867006 G/A cg24463073 chr6:118973353 C6orf204 0.52 6.91 0.36 2.52e-11 Diastolic blood pressure; CRC trans rs4843747 0.671 rs28671027 chr16:88116323 G/A cg26811252 chr16:29126840 RRN3P2 0.67 9.25 0.45 2.88e-18 Menopause (age at onset); CRC cis rs7301016 0.846 rs11174576 chr12:63026436 C/T cg11441379 chr12:63026424 NA 0.53 5.76 0.3 1.97e-8 IgG glycosylation; CRC cis rs7264396 0.561 rs6142474 chr20:34574914 A/G cg04508476 chr20:34239394 CPNE1;RBM12 0.57 7.96 0.4 2.82e-14 Total cholesterol levels; CRC cis rs3772130 0.923 rs4298081 chr3:121526037 T/G cg20356878 chr3:121714668 ILDR1 0.51 8.05 0.41 1.5e-14 Cognitive performance; CRC cis rs1568889 1.000 rs11603799 chr11:28196488 T/A cg06544937 chr11:28130018 METT5D1;KIF18A 0.8 11.58 0.54 3.17e-26 Bipolar disorder; CRC cis rs4728302 0.869 rs2042455 chr7:133580545 A/G cg10665199 chr7:133106180 EXOC4 0.42 6.32 0.33 8.64e-10 Intelligence;Intelligence (multi-trait analysis); CRC trans rs57221529 0.709 rs72706611 chr5:561146 C/A cg11887960 chr12:57824829 NA 0.58 6.42 0.33 4.87e-10 Lung disease severity in cystic fibrosis; CRC trans rs459571 0.959 rs416390 chr9:136908549 C/G cg09836344 chr4:1243392 C4orf42;CTBP1 0.82 11.59 0.54 2.78e-26 Platelet distribution width; CRC cis rs9322193 0.962 rs4870048 chr6:150155460 A/G cg07701084 chr6:150067640 NUP43 0.44 6.22 0.32 1.5e-9 Lung cancer; CRC trans rs8002861 0.664 rs4941474 chr13:44450289 C/T cg17145862 chr1:211918768 LPGAT1 0.57 9.73 0.47 8.02e-20 Leprosy; CRC trans rs1005277 0.579 rs2474574 chr10:38387295 C/T cg11292332 chr7:45801988 SEPT13 -0.35 -6.26 -0.33 1.18e-9 Extrinsic epigenetic age acceleration; CRC cis rs35740288 0.539 rs4843101 chr15:86339661 G/T cg20737812 chr15:86336631 KLHL25 -0.47 -7.19 -0.37 4.5e-12 Eosinophil percentage of white cells;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes; CRC cis rs7119 0.635 rs59745219 chr15:77884130 A/G cg10437265 chr15:77819839 NA -0.44 -7.82 -0.4 7.44e-14 Type 2 diabetes; CRC cis rs7131987 0.675 rs1436322 chr12:29554805 A/G cg09582351 chr12:29534625 ERGIC2 0.31 6.6 0.34 1.67e-10 QT interval; CRC cis rs910316 1.000 rs4903284 chr14:75592483 G/C cg08847533 chr14:75593920 NEK9 0.93 17.52 0.69 5.2e-49 Height; CRC cis rs7918232 0.505 rs788221 chr10:27442247 G/C cg14442939 chr10:27389572 ANKRD26 -0.96 -9.67 -0.47 1.23e-19 Breast cancer; CRC cis rs2153535 0.580 rs1328862 chr6:8526681 A/T cg21535247 chr6:8435926 SLC35B3 0.49 7.51 0.38 5.8e-13 Motion sickness; CRC cis rs9487051 1.000 rs9487052 chr6:109617086 C/T cg21918786 chr6:109611834 NA -0.38 -6.57 -0.34 1.95e-10 Reticulocyte fraction of red cells; CRC cis rs7927771 1.000 rs7120333 chr11:47817441 C/T cg05585544 chr11:47624801 NA -0.61 -10.84 -0.51 1.25e-23 Subjective well-being; CRC cis rs57221529 0.766 rs28563961 chr5:554498 C/G cg17948913 chr5:572064 NA 0.56 6.36 0.33 6.88e-10 Lung disease severity in cystic fibrosis; CRC cis rs9488822 0.676 rs12154016 chr6:116355188 C/T cg15226275 chr6:116381976 FRK 0.29 8.35 0.42 1.87e-15 Cholesterol, total;LDL cholesterol; CRC cis rs1153858 1.000 rs7167900 chr15:45639471 A/G cg10760299 chr15:45669010 GATM 0.5 7.97 0.4 2.72e-14 Homoarginine levels; CRC cis rs933688 1.000 rs6867091 chr5:90734333 C/G cg02339078 chr5:90679543 LOC100129716;ARRDC3 0.85 14.81 0.63 2.14e-38 Smoking behavior; CRC cis rs1552244 1.000 rs9879080 chr3:10084224 C/T cg08888203 chr3:10149979 C3orf24 0.7 10.01 0.48 8.99e-21 Alzheimer's disease; CRC cis rs79149102 0.579 rs74023935 chr15:75359184 T/C cg17294928 chr15:75287854 SCAMP5 -0.62 -5.95 -0.31 7.02e-9 Lung cancer; CRC cis rs10979 1.000 rs9376761 chr6:143887165 G/A cg25407410 chr6:143891975 LOC285740 -0.8 -12.92 -0.58 3.63e-31 Hypospadias; CRC trans rs1005277 0.579 rs2472174 chr10:38375382 A/G cg27523141 chr10:43048294 ZNF37B 0.5 7.33 0.37 1.83e-12 Extrinsic epigenetic age acceleration; CRC cis rs916888 0.821 rs70602 chr17:44859715 T/C cg01570182 chr17:44337453 NA -1.07 -12.8 -0.58 9.93e-31 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs2739330 0.796 rs1006771 chr22:24314006 G/T cg24846343 chr22:24311635 DDTL 0.66 10.65 0.51 5.86e-23 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs8180040 0.932 rs62248599 chr3:47516728 G/A cg27129171 chr3:47204927 SETD2 -0.6 -9.27 -0.45 2.59e-18 Colorectal cancer; CRC cis rs747650 0.926 rs11039119 chr11:47201924 G/A cg03339077 chr11:47165057 C11orf49 -0.45 -6.16 -0.32 2.18e-9 Acne (severe); CRC cis rs2408955 0.521 rs11168437 chr12:48566156 C/T cg15465823 chr12:48382534 COL2A1 0.38 6.14 0.32 2.4e-9 Glycated hemoglobin levels; CRC cis rs73206853 0.841 rs3759382 chr12:110889483 G/A cg12870014 chr12:110450643 ANKRD13A 0.75 8.21 0.41 5.25e-15 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC cis rs2204008 0.687 rs2320523 chr12:38251397 T/C cg13010199 chr12:38710504 ALG10B 0.45 5.95 0.31 6.72e-9 Bladder cancer; CRC cis rs28386778 0.897 rs1062788 chr17:61896127 C/G cg11494091 chr17:61959527 GH2 0.6 10.1 0.49 4.51e-21 Prudent dietary pattern; CRC cis rs7618915 0.501 rs767418 chr3:52767427 C/T cg08222913 chr3:52553049 STAB1 -0.33 -6.12 -0.32 2.72e-9 Bipolar disorder; CRC cis rs2280630 0.529 rs4342048 chr3:39012943 A/G cg01426195 chr3:39028469 NA -0.42 -6.99 -0.36 1.57e-11 Verbal declarative memory; CRC cis rs847577 0.609 rs34320230 chr7:97785500 C/T cg24562669 chr7:97807699 LMTK2 0.79 17.53 0.69 4.71e-49 Breast cancer; CRC cis rs921968 0.613 rs2303565 chr2:219545309 T/C cg02176678 chr2:219576539 TTLL4 -0.46 -7.28 -0.37 2.48e-12 Mean corpuscular hemoglobin concentration; CRC cis rs10791323 0.536 rs4937842 chr11:133734542 C/G cg15485101 chr11:133734466 NA -0.49 -8.77 -0.44 1.01e-16 Childhood ear infection; CRC cis rs3820068 0.705 rs4646072 chr1:15827711 G/A cg27534772 chr1:16042836 PLEKHM2 0.41 6.95 0.36 1.99e-11 Systolic blood pressure; CRC cis rs9649213 0.574 rs6979373 chr7:97961844 T/C cg21770322 chr7:97807741 LMTK2 0.51 8.33 0.42 2.26e-15 Prostate cancer (SNP x SNP interaction); CRC cis rs4980532 1 rs4980532 chr11:63680719 C/T cg04850017 chr11:63683019 RCOR2 0.33 5.89 0.31 9.53e-9 Pulse pressure; CRC cis rs853679 0.517 rs4713141 chr6:28101678 G/C cg06470822 chr6:28175283 NA 1.0 13.33 0.59 1.06e-32 Depression; CRC cis rs7487075 0.619 rs9669404 chr12:46798963 A/G cg22049899 chr12:47219821 SLC38A4 -0.31 -5.77 -0.3 1.85e-8 Itch intensity from mosquito bite; CRC cis rs2115630 1.000 rs56074163 chr15:85351332 C/T cg12501888 chr15:85177176 SCAND2 -0.35 -5.64 -0.3 3.67e-8 P wave terminal force; CRC trans rs2727020 0.521 rs937430 chr11:49542457 A/G cg03929089 chr4:120376271 NA 0.77 10.39 0.5 4.63e-22 Coronary artery disease; CRC cis rs7666738 0.830 rs11727653 chr4:99001774 T/C cg17366294 chr4:99064904 C4orf37 0.44 7.39 0.38 1.19e-12 Colonoscopy-negative controls vs population controls; CRC cis rs4253772 0.637 rs6008357 chr22:46652104 T/G cg09491104 chr22:46646882 C22orf40 -0.49 -7.63 -0.39 2.51e-13 LDL cholesterol;Cholesterol, total; CRC cis rs896854 0.624 rs9297949 chr8:95969445 A/C cg09323728 chr8:95962352 TP53INP1 -0.45 -7.56 -0.38 3.98e-13 Type 2 diabetes; CRC trans rs7395662 0.963 rs7951432 chr11:48591280 T/A cg21153622 chr11:89784906 NA -0.46 -7.33 -0.37 1.85e-12 HDL cholesterol; CRC cis rs12594515 0.600 rs12903858 chr15:45972166 A/G cg01629716 chr15:45996671 NA 0.34 6.75 0.35 6.68e-11 Waist circumference;Weight; CRC cis rs1552244 1.000 rs35198334 chr3:10104553 G/C cg02579736 chr3:10068473 FANCD2;CIDECP 1.04 13.74 0.6 3e-34 Alzheimer's disease; CRC cis rs863345 0.604 rs10797011 chr1:158465371 T/C cg12129480 chr1:158549410 OR10X1 -0.3 -6.29 -0.33 9.9e-10 Pneumococcal bacteremia; CRC cis rs72781680 0.611 rs36052574 chr2:24306587 A/C cg20701182 chr2:24300061 SF3B14 0.65 7.52 0.38 5.13e-13 Lymphocyte counts; CRC trans rs13046373 0.905 rs4816372 chr21:32077414 A/T cg13139730 chr1:161576322 HSPA7 -0.38 -6.17 -0.32 1.99e-9 HDL cholesterol; CRC cis rs4563143 0.663 rs73025068 chr19:29238998 G/A cg04546413 chr19:29218101 NA 0.41 6.41 0.33 5.01e-10 Methadone dose in opioid dependence; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg14417830 chr9:137977929 OLFM1 0.41 6.17 0.32 2.02e-9 Response to antipsychotic treatment; CRC cis rs2932538 0.922 rs112363416 chr1:113107543 T/C cg22162597 chr1:113214053 CAPZA1 0.7 9.85 0.48 3.1e-20 Systolic blood pressure;Diastolic blood pressure;Hypertension;Blood pressure; CRC cis rs798554 0.679 rs2533877 chr7:2882421 G/A cg04166393 chr7:2884313 GNA12 0.56 7.49 0.38 6.51e-13 Height; CRC cis rs1465370 0.692 rs2402996 chr7:130017003 C/T cg03229158 chr7:130009420 NA 0.44 6.26 0.33 1.23e-9 Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction);Waist circumference adjusted for BMI in active individuals;Waist circumference adjusted for body mass index; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg15174977 chr3:52931857 TMEM110 0.4 6.52 0.34 2.57e-10 Liver disease severity in Alagille syndrome; CRC cis rs514406 0.683 rs10157120 chr1:53210888 A/G cg08859206 chr1:53392774 SCP2 -0.41 -6.46 -0.34 3.85e-10 Monocyte count; CRC cis rs798554 0.660 rs2644275 chr7:2854010 G/A cg13628971 chr7:2884303 GNA12 0.41 6.25 0.33 1.28e-9 Height; CRC cis rs2404602 0.716 rs12441247 chr15:76812316 T/C cg00316803 chr15:76480434 C15orf27 -0.36 -5.83 -0.31 1.3e-8 Blood metabolite levels; CRC cis rs995000 0.895 rs11208001 chr1:63130431 C/T cg19896129 chr1:63156450 NA 0.4 6.03 0.32 4.52e-9 Triglyceride levels; CRC trans rs10802346 0.545 rs2362253 chr1:246371676 G/A cg22732515 chr19:44031385 ETHE1 0.69 10.35 0.5 6.57e-22 Fractional exhaled nitric oxide (childhood); CRC trans rs3942852 0.955 rs7117386 chr11:48125371 G/A cg15704280 chr7:45808275 SEPT13 -0.57 -7.12 -0.37 6.66e-12 Acute lymphoblastic leukemia (childhood); CRC cis rs7618915 0.547 rs6768697 chr3:52703615 C/T cg07507251 chr3:52567010 NT5DC2 0.46 6.6 0.34 1.68e-10 Bipolar disorder; CRC trans rs13046373 0.905 rs4816372 chr21:32077414 A/T cg21565078 chr2:241069202 MYEOV2 -0.36 -6.09 -0.32 3.09e-9 HDL cholesterol; CRC cis rs910316 0.737 rs175043 chr14:75471803 G/A cg11812906 chr14:75593930 NEK9 -0.6 -8.98 -0.44 2.11e-17 Height; CRC cis rs1670533 1.000 rs10031302 chr4:1059664 G/A cg27284194 chr4:1044797 NA 0.5 6.31 0.33 8.84e-10 Recombination rate (females); CRC cis rs2243480 0.803 rs423187 chr7:65509499 G/C cg18252515 chr7:66147081 NA -1.23 -13.49 -0.6 2.59e-33 Diabetic kidney disease; CRC cis rs2070677 0.866 rs2492664 chr10:135387240 G/T cg20169779 chr10:135381914 SYCE1 -0.95 -14.96 -0.64 5.93e-39 Gout; CRC cis rs4664293 0.613 rs9784044 chr2:160622365 C/T cg08347373 chr2:160653686 CD302 -0.47 -7.43 -0.38 9.32e-13 Monocyte percentage of white cells; CRC cis rs4665809 1.000 rs10202478 chr2:26276049 T/C cg25036284 chr2:26402008 FAM59B -0.47 -6.23 -0.32 1.45e-9 Gut microbiome composition (summer); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg17938371 chr2:85555240 TGOLN2 0.39 5.96 0.31 6.38e-9 Intelligence (multi-trait analysis); CRC cis rs6570726 0.764 rs4263604 chr6:145916697 A/G cg23711669 chr6:146136114 FBXO30 0.75 12.55 0.57 8.33e-30 Lobe attachment (rater-scored or self-reported); CRC cis rs6570726 0.791 rs6918814 chr6:145906028 G/A cg05347473 chr6:146136440 FBXO30 0.36 5.63 0.3 3.88e-8 Lobe attachment (rater-scored or self-reported); CRC cis rs56146971 0.763 rs77450079 chr14:91863924 A/C cg16433844 chr14:91963127 SMEK1 -0.56 -5.84 -0.31 1.28e-8 Alzheimer disease and age of onset; CRC cis rs9443645 0.868 rs9443643 chr6:79798838 A/G cg11833968 chr6:79620685 NA -0.36 -6.11 -0.32 2.88e-9 Intelligence (multi-trait analysis); CRC cis rs7552404 0.696 rs67487205 chr1:76373756 T/C cg22875332 chr1:76189707 ACADM 0.63 7.72 0.39 1.45e-13 Blood metabolite levels;Acylcarnitine levels; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg20149998 chr11:73587608 CHCHD8;PAAF1 0.44 6.35 0.33 7.3e-10 Response to antipsychotic treatment; CRC trans rs951252 0.504 rs11734405 chr4:146081096 C/T cg09377915 chr6:56295593 NA -0.44 -6.19 -0.32 1.81e-9 Hip circumference; CRC cis rs17376456 0.825 rs28412976 chr5:93248377 T/C cg09848695 chr5:92956644 FAM172A;MIR2277 0.7 5.91 0.31 8.62e-9 Diabetic retinopathy; CRC cis rs2067615 0.507 rs10746064 chr12:107086245 G/T cg13491945 chr12:107078410 RFX4 0.37 6.29 0.33 9.86e-10 Heart rate; CRC cis rs12024301 0.557 rs12041570 chr1:183612890 T/C cg11505048 chr1:183622726 RGL1;APOBEC4 0.81 7.14 0.37 5.93e-12 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs4665809 0.590 rs962217 chr2:26438276 T/C cg26119090 chr2:26468346 HADHA;HADHB -1.05 -15.11 -0.64 1.5e-39 Gut microbiome composition (summer); CRC cis rs9372498 0.572 rs10484289 chr6:118827836 T/C cg15382696 chr6:118971807 C6orf204 0.57 7.49 0.38 6.32e-13 Diastolic blood pressure; CRC cis rs7223966 0.960 rs2854222 chr17:61939015 C/T cg23090583 chr17:61904693 PSMC5;FTSJ3 0.48 6.14 0.32 2.41e-9 Hip circumference adjusted for BMI;Body mass index; CRC cis rs9322193 0.884 rs11155669 chr6:149954637 T/C cg13206674 chr6:150067644 NUP43 0.65 9.76 0.47 6.33e-20 Lung cancer; CRC cis rs1865760 0.713 rs9461229 chr6:25992279 G/T cg16482183 chr6:26056742 HIST1H1C 0.51 7.67 0.39 2.02e-13 Height; CRC cis rs6502050 0.805 rs6502061 chr17:80086158 C/T cg02741985 chr17:80059408 CCDC57 -0.44 -7.18 -0.37 4.75e-12 Life satisfaction; CRC cis rs7635838 0.620 rs1666988 chr3:11284950 A/G cg00170343 chr3:11313890 ATG7 0.55 8.22 0.41 4.68e-15 HDL cholesterol; CRC cis rs7412746 0.611 rs10888398 chr1:150886782 A/G cg17724175 chr1:150552817 MCL1 -0.4 -6.15 -0.32 2.26e-9 Melanoma; CRC cis rs12477438 0.765 rs62156363 chr2:99693324 G/A cg14399236 chr2:99771627 LIPT1;TSGA10 -0.6 -8.19 -0.41 6.03e-15 Chronic sinus infection; CRC cis rs13217239 0.646 rs10946891 chr6:26973215 T/C cg18867708 chr6:26865862 GUSBL1 0.38 5.82 0.31 1.39e-8 Schizophrenia; CRC cis rs6540556 0.954 rs10489342 chr1:209935778 A/G cg23920097 chr1:209922102 NA -0.52 -6.59 -0.34 1.72e-10 Red blood cell count; CRC cis rs7591163 1.000 rs4973380 chr2:228725402 T/A cg22079747 chr2:228736145 WDR69 -0.42 -5.76 -0.3 1.9e-8 Blood pressure; CRC cis rs6121246 0.559 rs6060716 chr20:30274847 C/G cg13852791 chr20:30311386 BCL2L1 0.73 14.1 0.61 1.22e-35 Mean corpuscular hemoglobin; CRC cis rs2735413 0.709 rs8051521 chr16:78088156 G/C cg04733911 chr16:78082701 NA 0.43 6.86 0.35 3.46e-11 Systolic blood pressure (alcohol consumption interaction); CRC cis rs6541297 1.000 rs4846838 chr1:230281618 G/A cg20703242 chr1:230279135 GALNT2 0.49 6.55 0.34 2.17e-10 Coronary artery disease; CRC cis rs73198271 0.562 rs11774860 chr8:8651879 C/T cg01851573 chr8:8652454 MFHAS1 0.54 6.75 0.35 6.71e-11 Bone ultrasound measurement (broadband ultrasound attenuation); CRC trans rs6703335 0.870 rs10803142 chr1:243598234 A/G cg01745510 chr12:12870119 CDKN1B 0.45 6.2 0.32 1.74e-9 Schizophrenia;Schizophrenia, schizoaffective disorder or bipolar disorder; CRC cis rs6831352 0.918 rs29001195 chr4:100054244 G/T cg13256891 chr4:100009986 ADH5 -0.66 -8.89 -0.44 4.04e-17 Alcohol dependence; CRC cis rs17401966 0.540 rs10864452 chr1:10395683 G/T cg19773385 chr1:10388646 KIF1B -0.49 -7.71 -0.39 1.54e-13 Hepatocellular carcinoma; CRC cis rs6963495 0.818 rs6977748 chr7:105167462 T/G cg02135003 chr7:105160482 PUS7 -0.91 -12.14 -0.56 2.73e-28 Bipolar disorder (body mass index interaction); CRC cis rs8180040 0.874 rs11130123 chr3:47285912 A/G cg10298567 chr3:47292165 KIF9 -0.4 -6.52 -0.34 2.66e-10 Colorectal cancer; CRC cis rs769267 0.930 rs7254927 chr19:19404786 C/G cg03709012 chr19:19516395 GATAD2A 0.71 10.97 0.52 4.39e-24 Tonsillectomy; CRC cis rs2456568 0.867 rs1827931 chr11:93663170 T/C cg26875233 chr11:93583750 C11orf90 -0.33 -6.5 -0.34 2.96e-10 Response to serotonin reuptake inhibitors in major depressive disorder; CRC cis rs10751667 0.666 rs7103585 chr11:971166 T/C ch.11.42038R chr11:967971 AP2A2 0.58 9.98 0.48 1.16e-20 Alzheimer's disease (late onset); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg18934136 chr17:55927456 MRPS23 0.38 5.97 0.31 6.1e-9 Liver disease severity in Alagille syndrome; CRC cis rs7727544 0.716 rs72793283 chr5:131566941 G/A cg02033258 chr5:131593261 PDLIM4 0.35 6.61 0.34 1.54e-10 Blood metabolite levels; CRC cis rs9303401 0.921 rs34102441 chr17:56877414 A/G cg02118635 chr17:56770003 RAD51C;TEX14 0.55 8.16 0.41 6.95e-15 Cognitive test performance; CRC cis rs12474201 0.832 rs6738426 chr2:46986416 A/G cg06386533 chr2:46925753 SOCS5 0.76 12.31 0.56 6.57e-29 Height; CRC cis rs2739330 0.796 rs5760106 chr22:24250645 A/C cg04234412 chr22:24373322 LOC391322 0.71 11.07 0.52 2.09e-24 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs4713118 0.869 rs9468214 chr6:27713299 G/C cg20933634 chr6:27740509 NA 0.58 8.39 0.42 1.42e-15 Parkinson's disease; CRC cis rs7605827 0.930 rs13029846 chr2:15674686 T/C cg19274914 chr2:15703543 NA 0.37 5.7 0.3 2.62e-8 Educational attainment (years of education); CRC cis rs798554 0.607 rs1182151 chr7:2909225 C/G cg19346786 chr7:2764209 NA -0.34 -5.7 -0.3 2.61e-8 Height; CRC cis rs4319547 0.695 rs4758662 chr12:122924778 G/A cg05707623 chr12:122985044 ZCCHC8 -0.73 -9.2 -0.45 4.31e-18 Body mass index; CRC cis rs7493 0.950 rs17879277 chr7:95030632 A/C cg19678392 chr7:94953810 PON1 -0.59 -7.3 -0.37 2.22e-12 Yu-Zhi constitution type in type 2 diabetes; CRC trans rs2303319 0.504 rs12467625 chr2:162603387 C/A cg03774468 chr3:140950104 ACPL2 -0.65 -6.07 -0.32 3.61e-9 Cognitive function; CRC cis rs8180040 0.647 rs57756484 chr3:47239333 A/G cg10298567 chr3:47292165 KIF9 0.4 6.28 0.33 1.08e-9 Colorectal cancer; CRC cis rs780096 0.506 rs780100 chr2:27652153 G/T cg02592271 chr2:27665507 KRTCAP3 -0.28 -6.39 -0.33 5.62e-10 Total body bone mineral density; CRC cis rs1843834 0.838 rs6436506 chr2:225558242 T/C cg22455342 chr2:225449267 CUL3 0.42 5.63 0.3 3.78e-8 IgE levels in asthmatics (D.p. specific); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg06624832 chr17:72772340 TMEM104;NAT9 0.47 6.64 0.34 1.29e-10 Intelligence (multi-trait analysis); CRC cis rs2011503 1.000 rs4808205 chr19:19645493 T/G cg11584989 chr19:19387371 SF4 0.59 6.53 0.34 2.48e-10 Bipolar disorder; CRC cis rs1862618 0.853 rs832554 chr5:56115036 A/G cg18230493 chr5:56204884 C5orf35 -0.71 -9.22 -0.45 3.64e-18 Initial pursuit acceleration; CRC cis rs1448094 0.511 rs10779207 chr12:86152913 A/G cg25456477 chr12:86230367 RASSF9 -0.39 -6.54 -0.34 2.36e-10 Major depressive disorder; CRC cis rs172166 0.515 rs2622320 chr6:28115336 T/A cg12273811 chr6:28175739 NA 0.46 6.94 0.36 2.04e-11 Cardiac Troponin-T levels; CRC cis rs873946 0.648 rs12767283 chr10:134557094 C/G cg27286337 chr10:134555280 INPP5A 0.84 10.25 0.49 1.42e-21 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CRC cis rs4242434 0.699 rs878053 chr8:22483849 T/C cg03733263 chr8:22462867 KIAA1967 0.89 15.79 0.66 3.4e-42 Exploratory eye movement dysfunction in schizophrenia (cognitive search score); CRC trans rs1005277 0.563 rs2800550 chr10:38482929 T/C cg17830980 chr10:43048298 ZNF37B -0.6 -9.93 -0.48 1.76e-20 Extrinsic epigenetic age acceleration; CRC cis rs2404602 0.647 rs118129828 chr15:77015200 T/C cg23625390 chr15:77176239 SCAPER -0.87 -14.35 -0.62 1.39e-36 Blood metabolite levels; CRC cis rs10911363 0.550 rs10911353 chr1:183489203 G/A cg09173681 chr1:183549694 NCF2 0.75 10.37 0.5 5.35e-22 Systemic lupus erythematosus; CRC cis rs875971 0.862 rs10263690 chr7:65766453 G/C cg18876405 chr7:65276391 NA -0.53 -8.45 -0.42 9.32e-16 Aortic root size; CRC cis rs4243830 0.850 rs1114661 chr1:6596871 G/A cg22792644 chr1:6614718 TAS1R1;NOL9 -0.79 -9.58 -0.47 2.52e-19 Body mass index; CRC cis rs727505 1.000 rs10265763 chr7:124451514 G/A cg23710748 chr7:124431027 NA -0.81 -14.48 -0.62 4.19e-37 Lewy body disease; CRC cis rs13256369 0.951 rs13260947 chr8:8565883 A/G cg00074818 chr8:8560427 CLDN23 0.38 6.93 0.36 2.2e-11 Obesity-related traits; CRC cis rs853679 0.760 rs967005 chr6:28210688 C/T cg06470822 chr6:28175283 NA 0.76 8.05 0.41 1.49e-14 Depression; CRC cis rs6684514 1.000 rs6800 chr1:156262653 A/C cg16558208 chr1:156270281 VHLL 0.58 9.04 0.45 1.34e-17 Mean corpuscular hemoglobin concentration;Glycated hemoglobin levels; CRC cis rs3789045 0.866 rs11584700 chr1:204576983 C/T cg17419461 chr1:204415978 PIK3C2B 0.53 7.59 0.39 3.29e-13 Educational attainment (college completion); CRC cis rs6952809 0.504 rs1978169 chr7:2434522 G/A cg23289794 chr7:2394357 EIF3B -0.69 -8.59 -0.43 3.43e-16 Multiple sclerosis; CRC cis rs2242663 0.705 rs551708 chr11:66486143 T/C cg24851651 chr11:66362959 CCS -0.44 -7.38 -0.38 1.31e-12 Bipolar disorder; CRC cis rs4604732 0.578 rs79203328 chr1:247626581 C/G cg02104434 chr1:247694406 LOC148824;OR2C3 0.6 8.82 0.44 6.67e-17 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CRC cis rs2115630 0.645 rs1107179 chr15:85198362 A/C cg09876464 chr15:85330779 ZNF592 -0.38 -6.27 -0.33 1.14e-9 P wave terminal force; CRC cis rs12586317 0.514 rs74590021 chr14:35490113 T/G cg16230307 chr14:35515116 FAM177A1 0.89 10.49 0.5 2.13e-22 Psoriasis; CRC cis rs950169 0.960 rs35159785 chr15:84804014 G/A cg03959625 chr15:84868606 LOC388152 0.4 5.78 0.3 1.74e-8 Schizophrenia; CRC cis rs66573146 0.656 rs111560662 chr4:6952766 C/T cg26116260 chr4:7069785 GRPEL1 -0.69 -5.93 -0.31 7.61e-9 Granulocyte percentage of myeloid white cells; CRC cis rs9398803 0.835 rs9321065 chr6:126744087 G/A cg19875578 chr6:126661172 C6orf173 0.42 5.94 0.31 7.42e-9 Male-pattern baldness; CRC cis rs6938 0.662 rs12487 chr15:75136694 A/G cg09165964 chr15:75287851 SCAMP5 0.58 9.01 0.44 1.78e-17 Breast cancer; CRC cis rs3733585 0.673 rs7672947 chr4:9961368 G/C cg11266682 chr4:10021025 SLC2A9 -0.47 -9.47 -0.46 5.59e-19 Cleft plate (environmental tobacco smoke interaction); CRC trans rs7615952 0.512 rs34651730 chr3:125358640 T/C cg16558177 chr4:4109446 NA -0.62 -8.74 -0.43 1.23e-16 Blood pressure (smoking interaction); CRC cis rs853679 0.546 rs483143 chr6:27846744 G/C cg03623178 chr6:28175578 NA 0.78 6.8 0.35 4.91e-11 Depression; CRC cis rs68170813 0.523 rs7781947 chr7:106902219 A/G cg02696742 chr7:106810147 HBP1 -0.6 -6.65 -0.34 1.25e-10 Coronary artery disease; CRC cis rs4148883 0.603 rs1893883 chr4:100124716 C/G cg12011299 chr4:100065546 ADH4 0.4 8.61 0.43 3.14e-16 Alcohol dependence; CRC cis rs9486719 0.843 rs3849198 chr6:97036539 C/A cg06623918 chr6:96969491 KIAA0776 -0.81 -9.44 -0.46 7.3e-19 Migraine;Coronary artery disease; CRC cis rs35110281 0.720 rs162400 chr21:44950305 A/C cg04455712 chr21:45112962 RRP1B 0.42 8.19 0.41 5.86e-15 Mean corpuscular volume; CRC trans rs11673344 0.528 rs579452 chr19:37410838 C/T cg18947437 chr10:1231002 ADARB2 -0.36 -6.39 -0.33 5.73e-10 Obesity-related traits; CRC cis rs2991971 0.903 rs2991973 chr1:46020632 G/A cg15605315 chr1:45957053 TESK2 0.41 6.29 0.33 1.01e-9 High light scatter reticulocyte count; CRC cis rs4713118 0.539 rs510987 chr6:27847517 G/A cg10876282 chr6:28092338 ZSCAN16 0.45 5.86 0.31 1.14e-8 Parkinson's disease; CRC cis rs2404602 0.692 rs1867197 chr15:76910031 A/G cg03037974 chr15:76606532 NA -0.51 -8.31 -0.42 2.59e-15 Blood metabolite levels; CRC cis rs523522 0.962 rs670568 chr12:121021206 C/T cg12219531 chr12:120966889 COQ5 0.69 9.12 0.45 7.92e-18 High light scatter reticulocyte count; CRC cis rs2645694 0.626 rs2703126 chr4:77819842 T/C cg18351406 chr4:77819688 ANKRD56 0.5 7.53 0.38 5e-13 Emphysema distribution in smoking; CRC cis rs1953600 0.870 rs2788296 chr10:81937889 G/A cg00277334 chr10:82204260 NA 0.37 5.93 0.31 7.57e-9 Sarcoidosis; CRC trans rs62103177 0.713 rs62103186 chr18:77627574 G/C cg05926928 chr17:57297772 GDPD1 1.06 9.97 0.48 1.21e-20 Opioid sensitivity; CRC cis rs9381040 0.655 rs9394756 chr6:41016183 A/G cg03644281 chr6:41068752 NFYA;LOC221442 -0.46 -6.62 -0.34 1.44e-10 Alzheimer's disease (late onset); CRC cis rs28829049 0.597 rs72651403 chr1:19519887 G/C cg13387374 chr1:19411106 UBR4 0.41 5.96 0.31 6.53e-9 QRS duration in Tripanosoma cruzi seropositivity; CRC cis rs796364 1.000 rs769949 chr2:200729558 A/G cg12253985 chr2:200820533 C2orf60;C2orf47 0.59 6.54 0.34 2.31e-10 Schizophrenia; CRC cis rs853679 0.550 rs1150692 chr6:28173957 A/G cg15845792 chr6:28175446 NA 0.95 13.88 0.61 8.57e-35 Depression; CRC cis rs10450586 0.899 rs11029916 chr11:27311695 T/C cg10370305 chr11:27303972 NA 0.35 5.7 0.3 2.68e-8 Total body bone mineral density; CRC cis rs7829975 0.501 rs2980769 chr8:8320291 G/A cg06636001 chr8:8085503 FLJ10661 0.62 9.64 0.47 1.58e-19 Mood instability; CRC cis rs2120019 1.000 rs35577967 chr15:75354621 G/A cg17294928 chr15:75287854 SCAMP5 -0.79 -11.37 -0.53 1.68e-25 Blood trace element (Zn levels); CRC cis rs2839186 0.656 rs8128380 chr21:47665693 C/T cg20399509 chr21:47717575 C21orf57 -0.38 -6.38 -0.33 5.93e-10 Testicular germ cell tumor; CRC cis rs13217239 0.646 rs4403259 chr6:26997617 C/T cg18867708 chr6:26865862 GUSBL1 0.37 5.75 0.3 2.09e-8 Schizophrenia; CRC cis rs3087591 0.879 rs59015798 chr17:29580882 G/A cg24425628 chr17:29625626 OMG;NF1 -0.8 -13.52 -0.6 1.95e-33 Hip circumference; CRC cis rs9517313 0.770 rs9517301 chr13:99095088 A/G cg20487152 chr13:99095054 FARP1 -0.49 -8.17 -0.41 6.49e-15 Neuroticism; CRC cis rs9494145 0.680 rs4895441 chr6:135426573 C/T cg22676075 chr6:135203613 NA -0.55 -7.0 -0.36 1.46e-11 Mean platelet volume;Platelet count;Fetal hemoglobin levels in sickle cell anemia;Red blood cell traits; CRC cis rs3087591 0.960 rs2952976 chr17:29486152 G/A cg24425628 chr17:29625626 OMG;NF1 0.83 15.37 0.65 1.41e-40 Hip circumference; CRC cis rs62458065 0.850 rs62458066 chr7:32464484 C/T cg20159608 chr7:32802032 NA -0.54 -6.51 -0.34 2.8e-10 Metabolite levels (HVA/MHPG ratio); CRC cis rs7843479 0.601 rs2306645 chr8:21845428 C/T cg16476235 chr8:21771668 DOK2 -0.37 -6.11 -0.32 2.87e-9 Mean corpuscular volume; CRC cis rs938554 0.571 rs4144 chr4:10016322 T/C cg11266682 chr4:10021025 SLC2A9 0.43 7.13 0.37 6.31e-12 Blood metabolite levels; CRC cis rs3849570 0.883 rs28435942 chr3:81679692 C/T cg07356753 chr3:81810745 GBE1 -0.7 -9.76 -0.47 6.09e-20 Waist circumference;Body mass index; CRC cis rs4808199 0.948 rs11085261 chr19:19462606 G/A cg03709012 chr19:19516395 GATAD2A 0.88 10.79 0.51 1.93e-23 Nonalcoholic fatty liver disease; CRC cis rs4363385 0.747 rs4568784 chr1:152972694 G/A cg25856811 chr1:152973957 SPRR3 -0.25 -6.77 -0.35 5.97e-11 Inflammatory skin disease; CRC cis rs875971 0.545 rs13311962 chr7:66068129 C/T cg03233332 chr7:66118400 NA 0.45 6.21 0.32 1.64e-9 Aortic root size; CRC cis rs10206020 0.842 rs7609325 chr2:1574718 G/A cg12573674 chr2:1569213 NA -0.78 -10.48 -0.5 2.37e-22 IgG glycosylation; CRC cis rs6951245 1.000 rs118059236 chr7:1073202 A/C cg26224354 chr7:1096374 C7orf50;GPR146 -0.88 -11.08 -0.52 1.89e-24 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs9393692 0.905 rs4412192 chr6:26290377 A/G cg13736514 chr6:26305472 NA 0.59 10.84 0.51 1.3e-23 Educational attainment; CRC cis rs208520 0.690 rs12202913 chr6:66734198 C/T cg07460842 chr6:66804631 NA 1.06 14.74 0.63 4.07e-38 Exhaled nitric oxide output; CRC cis rs2032447 0.670 rs198834 chr6:26114372 G/A cg18357526 chr6:26021779 HIST1H4A -0.7 -10.42 -0.5 3.8e-22 Intelligence (multi-trait analysis); CRC cis rs6502050 0.835 rs3935129 chr17:80113381 G/C cg25804541 chr17:80189381 SLC16A3 -0.31 -5.97 -0.31 6.08e-9 Life satisfaction; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg02132458 chr4:57333267 SRP72 0.5 6.38 0.33 5.88e-10 Thyroid stimulating hormone; CRC cis rs9926296 0.605 rs1800287 chr16:89858525 C/G cg03388025 chr16:89894329 SPIRE2 0.43 8.56 0.43 4.25e-16 Vitiligo; CRC trans rs561341 0.505 rs548298 chr17:30297494 C/A cg20587970 chr11:113659929 NA -1.18 -17.22 -0.69 7.98e-48 Hip circumference adjusted for BMI; CRC cis rs2380220 0.872 rs4546494 chr6:95990626 A/C cg04719120 chr6:96025338 MANEA 0.58 6.62 0.34 1.48e-10 Behavioural disinhibition (generation interaction); CRC cis rs1707322 0.752 rs11211145 chr1:46108491 A/C cg03146154 chr1:46216737 IPP 0.67 9.37 0.46 1.21e-18 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs6681460 0.576 rs7355221 chr1:66986301 G/C cg02459107 chr1:67143332 SGIP1 0.38 5.87 0.31 1.09e-8 Presence of antiphospholipid antibodies; CRC cis rs1983891 0.955 rs2025645 chr6:41519654 A/G cg20194872 chr6:41519635 FOXP4 0.4 5.86 0.31 1.14e-8 Prostate cancer; CRC cis rs11122272 0.735 rs2808591 chr1:231523421 G/A cg06096015 chr1:231504339 EGLN1 0.4 5.98 0.31 5.78e-9 Hemoglobin concentration; CRC trans rs6472235 0.837 rs28605672 chr8:66929194 A/G cg07884673 chr3:53033167 SFMBT1 -0.45 -6.03 -0.32 4.47e-9 Myopia (pathological);Plateletcrit; CRC cis rs4713118 0.621 rs10484403 chr6:28033523 A/G cg25164649 chr6:28176230 NA 0.71 9.0 0.44 1.9e-17 Parkinson's disease; CRC cis rs10242455 0.571 rs73713595 chr7:99326659 G/A cg18809830 chr7:99032528 PTCD1 -0.96 -7.11 -0.36 7.45e-12 Blood metabolite levels; CRC cis rs11098499 0.754 rs12510269 chr4:120241646 A/G cg24375607 chr4:120327624 NA 0.48 7.61 0.39 2.87e-13 Corneal astigmatism; CRC cis rs7208859 0.725 rs7210904 chr17:29170205 G/A cg14008862 chr17:28927542 LRRC37B2 0.5 6.1 0.32 3.05e-9 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs861020 0.527 rs614662 chr1:209962419 C/T cg05527609 chr1:210001259 C1orf107 0.42 5.79 0.3 1.68e-8 Orofacial clefts; CRC cis rs35110281 0.591 rs162390 chr21:44936826 C/T cg04455712 chr21:45112962 RRP1B 0.4 7.58 0.39 3.51e-13 Mean corpuscular volume; CRC cis rs9527 0.590 rs10883818 chr10:104759586 A/G cg15744005 chr10:104629667 AS3MT -0.3 -5.96 -0.31 6.61e-9 Arsenic metabolism; CRC cis rs9372498 0.706 rs9489396 chr6:118761703 A/C cg22561889 chr6:118971681 C6orf204 0.53 6.87 0.35 3.16e-11 Diastolic blood pressure; CRC cis rs2457480 0.778 rs1704217 chr10:44729307 T/C cg09554077 chr10:44749378 NA 0.65 7.32 0.37 1.9e-12 Coronary artery disease; CRC cis rs6570726 0.846 rs6570698 chr6:145918635 C/G cg23711669 chr6:146136114 FBXO30 0.67 11.09 0.52 1.7e-24 Lobe attachment (rater-scored or self-reported); CRC cis rs853679 0.517 rs9380059 chr6:28132358 A/C cg02683197 chr6:28174875 NA 0.87 10.73 0.51 3.25e-23 Depression; CRC cis rs853679 0.517 rs4713146 chr6:28111536 A/T cg21251018 chr6:28226885 NKAPL 0.48 6.17 0.32 2.02e-9 Depression; CRC cis rs853679 1.000 rs68141011 chr6:28217797 G/T cg03623178 chr6:28175578 NA 0.73 6.88 0.35 3.12e-11 Depression; CRC cis rs6860806 0.507 rs272868 chr5:131680751 C/G cg18758796 chr5:131593413 PDLIM4 0.39 6.32 0.33 8.39e-10 Breast cancer; CRC cis rs2075371 0.501 rs1646654 chr7:134027547 G/C cg20476274 chr7:133979776 SLC35B4 0.6 9.18 0.45 4.8e-18 Mean platelet volume; CRC cis rs12893668 0.703 rs8017993 chr14:104047734 A/G cg08213375 chr14:104286397 PPP1R13B 0.35 5.61 0.3 4.38e-8 Reticulocyte count; CRC cis rs875971 1.000 rs2420820 chr7:66091907 T/C cg00343986 chr7:65444356 GUSB -0.46 -6.49 -0.34 3.14e-10 Aortic root size; CRC cis rs2243480 1.000 rs313803 chr7:65514731 G/A cg25985355 chr7:65971099 NA -0.54 -6.14 -0.32 2.35e-9 Diabetic kidney disease; CRC cis rs743757 1.000 rs2236957 chr3:50440426 A/G cg09545109 chr3:50388910 TUSC4;CYB561D2 0.43 6.32 0.33 8.56e-10 Diastolic blood pressure; CRC cis rs477692 0.870 rs475250 chr10:131412558 C/G cg05714579 chr10:131428358 MGMT 0.61 8.77 0.44 9.49e-17 Response to temozolomide; CRC cis rs28386778 0.897 rs4638645 chr17:61828349 T/C cg06873352 chr17:61820015 STRADA 0.79 14.96 0.64 5.82e-39 Prudent dietary pattern; CRC cis rs4853012 0.838 rs60705299 chr2:74345370 C/G cg05890377 chr2:74357713 NA 0.57 9.32 0.46 1.68e-18 Gestational age at birth (maternal effect); CRC cis rs17001868 0.568 rs470113 chr22:40729614 A/G cg07138101 chr22:40742427 ADSL 0.54 6.68 0.35 1.04e-10 Mammographic density (dense area); CRC cis rs6089584 0.925 rs35683654 chr20:60625401 G/T cg13770153 chr20:60521292 NA 0.71 10.55 0.5 1.32e-22 Body mass index; CRC cis rs1448094 0.511 rs17279338 chr12:86162874 G/A cg18827107 chr12:86230957 RASSF9 -0.37 -5.73 -0.3 2.23e-8 Major depressive disorder; CRC cis rs9311474 0.652 rs411457 chr3:52228150 A/T cg18099408 chr3:52552593 STAB1 0.35 5.85 0.31 1.17e-8 Electroencephalogram traits; CRC cis rs4363385 0.617 rs5010885 chr1:152973141 C/T cg25856811 chr1:152973957 SPRR3 -0.25 -6.77 -0.35 5.85e-11 Inflammatory skin disease; CRC cis rs45509595 0.749 rs401763 chr6:27782528 T/C cg03623178 chr6:28175578 NA 0.78 6.64 0.34 1.27e-10 Breast cancer; CRC cis rs2795502 0.506 rs11819501 chr10:43465544 C/T cg20628663 chr10:43360327 NA 0.6 7.25 0.37 2.95e-12 Blood protein levels; CRC cis rs58688157 0.660 rs7117022 chr11:583787 T/C cg09218773 chr11:619014 MUPCDH -0.4 -5.8 -0.3 1.53e-8 Systemic lupus erythematosus; CRC cis rs7615952 0.599 rs6438953 chr3:125724951 T/C cg06494592 chr3:125709126 NA -0.52 -6.86 -0.35 3.36e-11 Blood pressure (smoking interaction); CRC cis rs881375 0.967 rs758959 chr9:123676699 C/T cg14255062 chr9:123606675 PSMD5;LOC253039 0.42 6.1 0.32 3e-9 Rheumatoid arthritis; CRC cis rs1150668 0.796 rs213236 chr6:28324397 T/C cg06470822 chr6:28175283 NA 0.54 8.0 0.4 2.1e-14 Pubertal anthropometrics; CRC cis rs950169 1.000 rs12916348 chr15:84765527 C/T cg03959625 chr15:84868606 LOC388152 0.42 6.33 0.33 8.21e-10 Schizophrenia; CRC cis rs4282054 0.631 rs13081155 chr3:52732429 A/G cg18099408 chr3:52552593 STAB1 -0.53 -9.39 -0.46 1.06e-18 Cognitive function; CRC cis rs2797160 1.000 rs926853 chr6:126021435 A/T cg05901451 chr6:126070800 HEY2 0.4 6.13 0.32 2.47e-9 Endometrial cancer; CRC cis rs6460942 0.908 rs6978367 chr7:12232347 A/G cg06484146 chr7:12443880 VWDE -0.58 -6.05 -0.32 4.03e-9 Coronary artery disease; CRC cis rs9443645 0.869 rs9361489 chr6:79816785 T/C cg11833968 chr6:79620685 NA -0.36 -6.16 -0.32 2.15e-9 Intelligence (multi-trait analysis); CRC cis rs6543140 0.964 rs4851592 chr2:103087641 C/T cg03938978 chr2:103052716 IL18RAP 0.41 6.58 0.34 1.85e-10 Blood protein levels; CRC cis rs477895 0.653 rs11606544 chr11:63896901 C/T cg18225595 chr11:63971243 STIP1 0.56 7.28 0.37 2.51e-12 Mean platelet volume; CRC cis rs7605827 0.930 rs10929376 chr2:15692856 A/T cg19274914 chr2:15703543 NA 0.39 5.82 0.31 1.4e-8 Educational attainment (years of education); CRC cis rs911119 0.955 rs61035931 chr20:23595714 A/G cg16589663 chr20:23618590 CST3 0.44 6.16 0.32 2.12e-9 Chronic kidney disease; CRC cis rs4819052 0.885 rs28576202 chr21:46674684 G/A cg19498844 chr21:46707878 POFUT2;LOC642852 0.78 11.28 0.53 3.77e-25 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs7914558 0.933 rs1538204 chr10:104733893 T/A cg04362960 chr10:104952993 NT5C2 0.62 9.39 0.46 1.02e-18 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs7949030 0.626 rs72927213 chr11:62351198 G/C cg22862634 chr11:62369728 EML3;MTA2 0.59 10.23 0.49 1.71e-21 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; CRC cis rs936229 0.813 rs8033381 chr15:75080685 G/A cg14664628 chr15:75095509 CSK -1.02 -19.9 -0.74 2.09e-58 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg07364046 chr12:93861583 MRPL42 0.45 6.78 0.35 5.55e-11 Intelligence (multi-trait analysis); CRC cis rs3820068 0.603 rs35509554 chr1:15993514 C/T cg27534772 chr1:16042836 PLEKHM2 0.51 9.3 0.46 1.96e-18 Systolic blood pressure; CRC cis rs12024301 0.557 rs12036825 chr1:183594432 A/G cg11505048 chr1:183622726 RGL1;APOBEC4 0.76 6.93 0.36 2.16e-11 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs999943 0.846 rs9357162 chr6:33613344 G/A cg14003231 chr6:33640908 ITPR3 0.93 16.41 0.67 1.29e-44 Obesity (extreme); CRC cis rs7666738 0.830 rs11725477 chr4:98803266 G/T cg17366294 chr4:99064904 C4orf37 0.4 6.2 0.32 1.68e-9 Colonoscopy-negative controls vs population controls; CRC cis rs28386778 0.805 rs9911714 chr17:61828952 G/A cg06873352 chr17:61820015 STRADA 0.79 14.94 0.64 6.66e-39 Prudent dietary pattern; CRC cis rs7493 1.000 rs12026 chr7:95041016 G/C cg17330251 chr7:94953956 PON1 -0.56 -7.22 -0.37 3.52e-12 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs73001065 0.636 rs8182472 chr19:19539891 A/G cg03709012 chr19:19516395 GATAD2A 0.75 6.32 0.33 8.49e-10 LDL cholesterol; CRC cis rs11971779 0.680 rs7799598 chr7:139051833 C/T cg23387468 chr7:139079360 LUC7L2 0.41 7.09 0.36 7.99e-12 Diisocyanate-induced asthma; CRC cis rs1448094 0.842 rs10863155 chr12:86446416 T/C cg18827107 chr12:86230957 RASSF9 0.36 5.61 0.3 4.25e-8 Major depressive disorder; CRC cis rs1223397 0.651 rs453877 chr6:13297463 G/T cg20827128 chr6:13274284 PHACTR1 0.37 5.61 0.3 4.39e-8 Blood pressure; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg14511745 chr11:47573874 CUGBP1 0.47 6.68 0.35 9.92e-11 Response to antipsychotic treatment; CRC cis rs7249142 0.549 rs12975253 chr19:19279745 A/C cg26504305 chr19:19281019 LOC729991-MEF2B;MEF2B -0.43 -8.77 -0.44 1.01e-16 IgG glycosylation; CRC cis rs10464366 0.746 rs6945547 chr7:39145389 C/G cg15212455 chr7:39170539 POU6F2 0.43 5.69 0.3 2.82e-8 IgG glycosylation; CRC cis rs9311474 0.508 rs3796353 chr3:52593230 C/T cg10802521 chr3:52805072 NEK4 -0.56 -8.91 -0.44 3.55e-17 Electroencephalogram traits; CRC cis rs832540 0.931 rs2662040 chr5:56246610 A/G cg18230493 chr5:56204884 C5orf35 0.42 6.31 0.33 8.96e-10 Coronary artery disease; CRC cis rs6582630 0.519 rs2387812 chr12:38381480 A/G cg26384229 chr12:38710491 ALG10B 0.68 9.75 0.47 6.92e-20 Drug-induced liver injury (flucloxacillin); CRC cis rs910316 1.000 rs11159117 chr14:75584867 C/T cg08847533 chr14:75593920 NEK9 0.93 18.06 0.71 3.89e-51 Height; CRC cis rs2281845 0.507 rs10800760 chr1:201100439 G/A cg22815214 chr1:201083145 CACNA1S 0.51 6.39 0.33 5.64e-10 Permanent tooth development; CRC cis rs6988636 1.000 rs4377946 chr8:124185887 T/C cg27053337 chr8:124217698 FAM83A 0.45 6.84 0.35 3.77e-11 Urinary uromodulin levels; CRC cis rs11608355 0.545 rs11066737 chr12:109904792 A/G cg05360138 chr12:110035743 NA -0.77 -8.37 -0.42 1.63e-15 Neuroticism; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg09003876 chr18:33552519 C18orf21 0.41 6.04 0.32 4.27e-9 Response to antipsychotic treatment; CRC cis rs9875589 0.509 rs1844107 chr3:14065319 C/G cg14375111 chr3:14165186 TMEM43;CHCHD4 0.41 6.13 0.32 2.46e-9 Ovarian reserve; CRC cis rs10464366 0.519 rs6974609 chr7:39219149 C/T cg21665744 chr7:39171113 POU6F2 0.45 5.89 0.31 9.32e-9 IgG glycosylation; CRC cis rs7605827 0.930 rs6431695 chr2:15539816 T/C cg19274914 chr2:15703543 NA 0.4 5.97 0.31 6.2e-9 Educational attainment (years of education); CRC cis rs6554196 0.895 rs7665611 chr4:55518878 C/A cg18836493 chr4:55524333 KIT -0.34 -5.65 -0.3 3.56e-8 Monocyte count; CRC cis rs801193 1.000 rs3857688 chr7:66127806 G/A cg00343986 chr7:65444356 GUSB -0.49 -7.23 -0.37 3.38e-12 Aortic root size; CRC cis rs873946 0.648 rs1548281 chr10:134552982 C/T cg06453172 chr10:134556979 INPP5A -0.71 -8.61 -0.43 3.04e-16 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CRC cis rs13064411 0.518 rs7637618 chr3:113176122 G/A cg18753928 chr3:113234510 CCDC52 -0.5 -7.96 -0.4 2.79e-14 Response to simvastatin treatment (PCSK9 protein level change); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg17915139 chr4:74904765 CXCL3 0.43 6.09 0.32 3.22e-9 Response to antipsychotic treatment; CRC cis rs514406 0.505 rs431459 chr1:53183230 T/G cg25767906 chr1:53392781 SCP2 -0.38 -5.86 -0.31 1.13e-8 Monocyte count; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg14511273 chr3:128746334 CCDC48 0.43 6.75 0.35 6.62e-11 Liver disease severity in Alagille syndrome; CRC cis rs7224737 1.000 rs35184688 chr17:40272406 G/C cg00647820 chr17:40259828 DHX58 -0.46 -6.49 -0.34 3.15e-10 Fibrinogen levels; CRC cis rs10791323 0.604 rs2851116 chr11:133705759 G/A cg15485101 chr11:133734466 NA 0.41 6.84 0.35 3.96e-11 Childhood ear infection; CRC cis rs13108904 0.935 rs2293633 chr4:1291640 T/C cg05665937 chr4:1216051 CTBP1 0.38 5.82 0.31 1.39e-8 Obesity-related traits; CRC cis rs17376456 0.877 rs12153788 chr5:93405437 A/G cg25358565 chr5:93447407 FAM172A 1.02 10.4 0.5 4.25e-22 Diabetic retinopathy; CRC cis rs4731207 0.596 rs6945951 chr7:124667200 T/C cg23710748 chr7:124431027 NA -0.38 -6.06 -0.32 3.73e-9 Cutaneous malignant melanoma; CRC cis rs3741404 0.665 rs12418535 chr11:63910980 A/G cg06219103 chr11:63990595 FERMT3 -0.38 -5.73 -0.3 2.29e-8 Platelet count; CRC cis rs7412746 0.634 rs4451553 chr1:150937329 C/T cg17724175 chr1:150552817 MCL1 0.46 6.86 0.35 3.43e-11 Melanoma; CRC cis rs883565 0.543 rs784488 chr3:39173135 C/G cg01426195 chr3:39028469 NA 0.42 7.0 0.36 1.48e-11 Handedness; CRC trans rs1547374 0.694 rs225349 chr21:43776890 C/T cg09521743 chr10:75415752 SYNPO2L 0.42 6.7 0.35 8.91e-11 Pancreatic cancer; CRC cis rs9322193 0.962 rs4816 chr6:150114745 G/A cg13206674 chr6:150067644 NUP43 0.57 8.14 0.41 8.29e-15 Lung cancer; CRC cis rs3749237 0.595 rs1568661 chr3:49520958 A/G cg03060546 chr3:49711283 APEH 0.62 10.43 0.5 3.41e-22 Resting heart rate; CRC cis rs2404602 0.552 rs11072613 chr15:76961526 A/C cg23625390 chr15:77176239 SCAPER -0.73 -9.89 -0.48 2.3e-20 Blood metabolite levels; CRC cis rs2115630 1.000 rs10220733 chr15:85280864 G/A cg11189052 chr15:85197271 WDR73 -0.61 -9.85 -0.48 3.17e-20 P wave terminal force; CRC trans rs79243044 0.786 rs16932549 chr11:5560909 C/T cg09032863 chr1:44412568 IPO13 -0.45 -6.03 -0.32 4.36e-9 QRS duration in Tripanosoma cruzi seropositivity; CRC cis rs7917772 0.636 rs7088981 chr10:104520423 T/C cg22532475 chr10:104410764 TRIM8 0.33 5.71 0.3 2.53e-8 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC cis rs9611565 0.729 rs9611570 chr22:41782721 G/T cg03806693 chr22:41940476 POLR3H -1.05 -13.43 -0.6 4.21e-33 Vitiligo; CRC cis rs9325144 0.723 rs1586373 chr12:39181582 G/A cg26384229 chr12:38710491 ALG10B -0.43 -5.76 -0.3 1.97e-8 Morning vs. evening chronotype; CRC cis rs881375 1.000 rs10818480 chr9:123643170 T/C cg09586646 chr9:123605570 PSMD5;LOC253039 0.5 6.83 0.35 4.22e-11 Rheumatoid arthritis; CRC cis rs2404602 1.000 rs2404740 chr15:76852143 C/T cg23625390 chr15:77176239 SCAPER 0.65 10.31 0.49 8.72e-22 Blood metabolite levels; CRC cis rs763121 0.853 rs5757200 chr22:39043491 T/G cg06544989 chr22:39130855 UNC84B 0.44 6.84 0.35 3.76e-11 Menopause (age at onset); CRC cis rs35110281 0.592 rs6417729 chr21:44967202 A/C cg01579765 chr21:45077557 HSF2BP -0.35 -6.48 -0.34 3.32e-10 Mean corpuscular volume; CRC cis rs11212617 0.870 rs227078 chr11:108250381 G/A cg12106634 chr11:108092400 ATM;NPAT 0.44 6.64 0.34 1.27e-10 Response to metformin in type 2 diabetes (glycemic); CRC cis rs28386778 0.897 rs2137144 chr17:61805607 G/A cg06873352 chr17:61820015 STRADA 0.74 13.7 0.6 4.05e-34 Prudent dietary pattern; CRC cis rs12477438 0.520 rs13012481 chr2:99754290 C/A cg14399236 chr2:99771627 LIPT1;TSGA10 0.84 14.99 0.64 4.43e-39 Chronic sinus infection; CRC trans rs7937682 0.924 rs10891286 chr11:111532691 C/G cg18187862 chr3:45730750 SACM1L 0.46 6.74 0.35 7.28e-11 Primary sclerosing cholangitis; CRC cis rs926938 0.618 rs6693491 chr1:115371061 A/G cg12756093 chr1:115239321 AMPD1 -0.58 -8.49 -0.42 7.15e-16 Autism; CRC cis rs4563143 0.675 rs56293553 chr19:29270455 A/G cg12756686 chr19:29218302 NA 0.61 9.12 0.45 7.57e-18 Methadone dose in opioid dependence; CRC cis rs7618915 0.501 rs12635140 chr3:52738165 C/T cg18099408 chr3:52552593 STAB1 0.45 7.57 0.38 3.89e-13 Bipolar disorder; CRC cis rs4908768 0.539 rs6670508 chr1:8647917 G/C cg20416874 chr1:8611966 RERE -0.41 -5.65 -0.3 3.44e-8 Neuroticism (multi-trait analysis);Subjective well-being (multi-trait analysis); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg23646337 chr19:42817556 TMEM145 0.41 6.86 0.35 3.46e-11 Liver disease severity in Alagille syndrome; CRC cis rs9660180 0.846 rs10907195 chr1:1713348 C/T cg03396347 chr1:1875803 NA 0.51 7.82 0.4 7.07e-14 Body mass index; CRC cis rs9916302 0.861 rs11078896 chr17:37415544 C/T cg03013999 chr17:37608204 MED1 0.48 7.5 0.38 5.93e-13 Glomerular filtration rate (creatinine); CRC cis rs2227564 0.620 rs11000787 chr10:75584383 T/C cg00564723 chr10:75632066 CAMK2G -0.32 -7.86 -0.4 5.42e-14 Crohn's disease;Inflammatory bowel disease; CRC trans rs6956675 0.915 rs7780762 chr7:62654263 T/C cg01314568 chr7:57830625 NA -0.62 -8.88 -0.44 4.41e-17 Obesity-related traits; CRC cis rs9322193 0.962 rs3763162 chr6:150140810 A/G cg05861140 chr6:150128134 PCMT1 0.46 7.43 0.38 9.38e-13 Lung cancer; CRC cis rs9486719 1.000 rs11153067 chr6:97039421 A/T cg18709589 chr6:96969512 KIAA0776 0.49 5.66 0.3 3.3e-8 Migraine;Coronary artery disease; CRC cis rs6963495 0.818 rs73192105 chr7:105167945 T/C cg02135003 chr7:105160482 PUS7 -0.9 -12.1 -0.56 3.88e-28 Bipolar disorder (body mass index interaction); CRC cis rs2708977 0.933 rs2708976 chr2:97184532 C/G cg01950434 chr2:97203154 ARID5A -0.46 -6.87 -0.35 3.28e-11 Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes; CRC cis rs9359856 0.564 rs56396054 chr6:90360406 C/T cg13799429 chr6:90582589 CASP8AP2 -0.74 -7.94 -0.4 3.18e-14 Bipolar disorder; CRC cis rs17270561 0.609 rs4131670 chr6:25738619 T/C cg17691542 chr6:26056736 HIST1H1C 0.73 9.26 0.45 2.71e-18 Iron status biomarkers; CRC cis rs45509595 0.841 rs2747054 chr6:27783359 A/G cg15845792 chr6:28175446 NA 0.72 6.15 0.32 2.24e-9 Breast cancer; CRC cis rs7247513 0.930 rs35275129 chr19:12716493 G/A cg01871581 chr19:12707946 ZNF490 -0.84 -15.47 -0.65 6.1e-41 Bipolar disorder; CRC cis rs10504229 0.683 rs72650847 chr8:58136825 C/T cg21724239 chr8:58056113 NA 0.74 9.13 0.45 7.35e-18 Developmental language disorder (linguistic errors); CRC cis rs896854 1.000 rs7003387 chr8:95961979 C/G cg16049864 chr8:95962084 TP53INP1 -0.67 -12.39 -0.56 3.32e-29 Type 2 diabetes; CRC trans rs9291683 0.668 rs2241474 chr4:10086015 T/C cg26043149 chr18:55253948 FECH 0.58 9.15 0.45 6e-18 Bone mineral density; CRC cis rs11252926 0.550 rs11252134 chr10:442599 G/A cg18196295 chr10:418757 DIP2C 0.49 7.64 0.39 2.37e-13 Psychosis in Alzheimer's disease; CRC cis rs1401999 1.000 rs7632670 chr3:183713877 A/G cg01324343 chr3:183735012 ABCC5 0.82 15.09 0.64 1.86e-39 Anterior chamber depth; CRC cis rs911555 0.755 rs9671414 chr14:103967299 C/T cg12935359 chr14:103987150 CKB 0.58 9.14 0.45 6.67e-18 Intelligence (multi-trait analysis); CRC cis rs2836950 0.565 rs8131132 chr21:40538256 T/C cg11644478 chr21:40555479 PSMG1 -0.51 -7.75 -0.39 1.16e-13 Menarche (age at onset); CRC cis rs2075371 0.734 rs13225086 chr7:134011411 C/T cg02659138 chr7:134003124 SLC35B4 0.39 6.62 0.34 1.42e-10 Mean platelet volume; CRC cis rs7208859 0.725 rs9915802 chr17:29173058 T/C cg13385521 chr17:29058706 SUZ12P 0.55 7.36 0.38 1.53e-12 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs72781680 0.611 rs4149373 chr2:24300023 C/T cg20701182 chr2:24300061 SF3B14 0.62 7.39 0.38 1.26e-12 Lymphocyte counts; CRC cis rs2072499 1.000 rs2253809 chr1:156172125 T/C cg24450063 chr1:156163899 SLC25A44 1.13 27.34 0.83 1.06e-86 Testicular germ cell tumor; CRC cis rs35883536 1.000 rs1855798 chr1:101114191 T/C cg14515779 chr1:101123966 NA -0.41 -7.87 -0.4 5.11e-14 Monocyte count; CRC cis rs6502050 0.871 rs8066970 chr17:80076051 T/C cg25804541 chr17:80189381 SLC16A3 0.32 6.24 0.33 1.33e-9 Life satisfaction; CRC cis rs4268898 0.662 rs55661701 chr2:24400769 A/C cg06627628 chr2:24431161 ITSN2 -0.86 -11.71 -0.54 1.02e-26 Asthma; CRC cis rs2228479 0.702 rs11076621 chr16:89837927 A/G cg06656553 chr16:89960601 TCF25 -0.7 -5.97 -0.31 6.14e-9 Skin colour saturation; CRC cis rs7811142 0.830 rs73401451 chr7:99981895 T/C cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.15 16.66 0.68 1.34e-45 Platelet count; CRC cis rs6570726 0.935 rs425731 chr6:145834151 A/G cg05347473 chr6:146136440 FBXO30 0.37 6.0 0.31 5.27e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs9611565 0.512 rs715498 chr22:42148467 G/A cg17554472 chr22:41940697 POLR3H 0.56 5.74 0.3 2.21e-8 Vitiligo; CRC cis rs7705042 0.865 rs6863411 chr5:141513204 A/T cg07392085 chr5:141489673 NDFIP1 0.44 7.12 0.37 6.83e-12 Asthma; CRC trans rs9393777 0.920 rs41269265 chr6:27425349 T/C cg06606381 chr12:133084897 FBRSL1 -1.11 -7.58 -0.39 3.5e-13 Intelligence (multi-trait analysis); CRC cis rs9311676 0.656 rs11130638 chr3:58405947 A/G cg06643156 chr3:58380774 PXK 0.42 6.38 0.33 5.84e-10 Systemic lupus erythematosus; CRC cis rs4563143 0.663 rs5025682 chr19:29238670 A/C cg04546413 chr19:29218101 NA 0.42 6.43 0.33 4.55e-10 Methadone dose in opioid dependence; CRC cis rs270601 0.661 rs10036208 chr5:131571323 T/C cg27615366 chr5:131592974 PDLIM4 0.35 6.19 0.32 1.81e-9 Acylcarnitine levels; CRC cis rs2153535 0.580 rs1034273 chr6:8468145 A/G cg07606381 chr6:8435919 SLC35B3 0.67 10.7 0.51 4.01e-23 Motion sickness; CRC cis rs4474465 0.790 rs7481910 chr11:78264202 G/C cg27205649 chr11:78285834 NARS2 0.51 6.52 0.34 2.65e-10 Alzheimer's disease (survival time); CRC cis rs8060686 0.858 rs7187289 chr16:67967878 A/C cg26727032 chr16:67993705 SLC12A4 -0.71 -10.76 -0.51 2.38e-23 HDL cholesterol;Metabolic syndrome; CRC cis rs910316 1.000 rs8003506 chr14:75586288 A/C cg11812906 chr14:75593930 NEK9 -0.65 -10.0 -0.48 9.64e-21 Height; CRC cis rs28386778 0.669 rs12603821 chr17:62006432 G/A cg22520471 chr17:61851767 DDX42;CCDC47 -0.56 -8.16 -0.41 7.26e-15 Prudent dietary pattern; CRC cis rs523522 0.892 rs4767916 chr12:121024032 T/C cg27279351 chr12:120934652 DYNLL1 0.74 10.54 0.5 1.46e-22 High light scatter reticulocyte count; CRC trans rs7142881 0.604 rs12887004 chr14:32286490 C/T cg07250515 chr12:56618133 OBFC2B -0.39 -5.98 -0.31 5.67e-9 Response to iloperidone treatment (QT prolongation); CRC cis rs4689592 0.513 rs4689586 chr4:7067413 A/G cg19539972 chr4:7069911 GRPEL1 0.75 9.66 0.47 1.37e-19 Monocyte percentage of white cells; CRC cis rs8060686 0.641 rs2285910 chr16:68104422 T/C cg26727032 chr16:67993705 SLC12A4 -0.57 -6.92 -0.36 2.43e-11 HDL cholesterol;Metabolic syndrome; CRC trans rs7615952 0.932 rs11922218 chr3:125631289 C/T cg07211511 chr3:129823064 LOC729375 -1.1 -17.5 -0.69 5.96e-49 Blood pressure (smoking interaction); CRC cis rs10760158 0.832 rs10513365 chr9:124020925 C/T cg14417974 chr9:124058376 GSN -0.34 -5.68 -0.3 2.96e-8 Pulse pressure; CRC trans rs17641971 0.899 rs341804 chr8:49991553 G/C cg18784943 chr17:79371681 NA 0.41 6.18 0.32 1.87e-9 Blood metabolite levels; CRC cis rs7552404 0.883 rs2185436 chr1:76203783 A/G cg10523679 chr1:76189770 ACADM 0.94 14.24 0.62 3.57e-36 Blood metabolite levels;Acylcarnitine levels; CRC cis rs4780401 0.967 rs11075012 chr16:11831030 T/C cg01061890 chr16:11836724 TXNDC11 -0.43 -5.75 -0.3 2.05e-8 Rheumatoid arthritis; CRC cis rs6088590 0.523 rs6059913 chr20:33143288 G/A cg08999081 chr20:33150536 PIGU 0.63 12.05 0.55 5.97e-28 Coronary artery disease; CRC cis rs11122272 0.735 rs2808603 chr1:231537738 T/C cg06096015 chr1:231504339 EGLN1 0.42 6.22 0.32 1.48e-9 Hemoglobin concentration; CRC cis rs7412746 0.622 rs72704654 chr1:150826410 G/A cg15448220 chr1:150897856 SETDB1 0.55 7.74 0.39 1.22e-13 Melanoma; CRC cis rs2019137 0.560 rs7578633 chr2:113978650 C/T cg17445212 chr2:113993313 PAX8;LOC440839;LOC654433 0.48 7.22 0.37 3.66e-12 Lymphocyte counts; CRC cis rs7267979 0.816 rs6138593 chr20:25504492 A/G cg24626310 chr20:25276739 ABHD12;PYGB 0.32 5.65 0.3 3.44e-8 Liver enzyme levels (alkaline phosphatase); CRC cis rs704795 0.836 rs1083865 chr2:27620827 A/G cg27432699 chr2:27873401 GPN1 -0.51 -7.71 -0.39 1.49e-13 Menopause (age at onset); CRC cis rs7264396 0.790 rs3787168 chr20:34233278 T/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.62 -10.4 -0.5 4.29e-22 Total cholesterol levels; CRC cis rs1912483 0.505 rs11079772 chr17:45393739 A/C cg08085267 chr17:45401833 C17orf57 0.71 11.07 0.52 1.97e-24 Coronary artery disease; CRC cis rs1555895 0.680 rs11253448 chr10:841115 T/C cg10556349 chr10:835070 NA -0.37 -6.97 -0.36 1.75e-11 Survival in rectal cancer; CRC cis rs11608355 0.846 rs61934479 chr12:109855111 A/G cg19025524 chr12:109796872 NA -0.45 -5.96 -0.31 6.61e-9 Neuroticism; CRC trans rs2303319 0.504 rs58622044 chr2:162596287 A/G cg18122310 chr12:50236657 BCDIN3D -0.73 -6.29 -0.33 1.02e-9 Cognitive function; CRC cis rs7959452 0.640 rs10878957 chr12:69699638 G/C cg20891283 chr12:69753455 YEATS4 0.79 13.19 0.59 3.55e-32 Blood protein levels; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg12638871 chr3:127842906 RUVBL1 0.44 6.56 0.34 2.11e-10 Intelligence (multi-trait analysis); CRC cis rs7089973 0.604 rs1359079 chr10:116582502 A/G cg23260525 chr10:116636907 FAM160B1 0.35 8.06 0.41 1.45e-14 Bipolar disorder or attention deficit hyperactivity disorder; CRC cis rs7811142 1.000 rs67040465 chr7:100083078 G/A cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.56 6.94 0.36 2.13e-11 Platelet count; CRC cis rs11628318 0.614 rs7143783 chr14:103128751 A/G cg12046867 chr14:103022105 NA 0.76 8.98 0.44 2.2e-17 Platelet count; CRC cis rs2408955 0.568 rs12099462 chr12:48503104 T/C cg21466736 chr12:48725269 NA 0.48 7.34 0.38 1.64e-12 Glycated hemoglobin levels; CRC trans rs887912 0.722 rs980183 chr2:59311536 A/G cg11150664 chr10:94351507 KIF11 -0.5 -6.07 -0.32 3.62e-9 Hip circumference;Body mass index;Obesity; CRC trans rs916888 0.647 rs199524 chr17:44848438 G/T cg01341218 chr17:43662625 NA -0.56 -6.95 -0.36 1.93e-11 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs10128264 0.902 rs942797 chr10:80986432 C/T cg20744163 chr10:80999841 ZMIZ1 -0.42 -7.24 -0.37 3.27e-12 Response to methotrexate in juvenile idiopathic arthritis; CRC cis rs6743376 0.642 rs4145014 chr2:113831185 A/G cg12858261 chr2:113808755 IL1F8 0.47 5.84 0.31 1.22e-8 Inflammatory biomarkers; CRC cis rs78456975 0.527 rs7590743 chr2:1575048 A/G cg26248373 chr2:1572462 NA -0.83 -12.38 -0.56 3.62e-29 Placebo response in major depressive disorder (% change in symptom score); CRC cis rs314370 0.951 rs12666989 chr7:100486754 G/C cg10426581 chr7:100472382 SRRT 0.62 7.06 0.36 9.92e-12 Resting heart rate; CRC cis rs9894429 0.634 rs9709130 chr17:79583948 C/T cg13777783 chr17:79615861 NA -0.3 -5.61 -0.3 4.26e-8 Eye color traits; CRC cis rs6951245 1.000 rs1881123 chr7:1084706 C/T cg07217954 chr7:1067459 C7orf50 0.55 5.61 0.3 4.23e-8 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs28493229 0.708 rs10408310 chr19:41161190 T/C cg21869046 chr19:41225005 ITPKC 0.41 6.15 0.32 2.26e-9 Kawasaki disease; CRC trans rs6472235 0.837 rs11995702 chr8:66926423 A/G cg07884673 chr3:53033167 SFMBT1 -0.46 -6.25 -0.33 1.27e-9 Myopia (pathological);Plateletcrit; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg05046026 chr11:61559981 C11orf10;FEN1;MIR611 0.39 6.45 0.34 3.95e-10 Liver disease severity in Alagille syndrome; CRC cis rs6502050 0.835 rs9904520 chr17:80100117 T/C cg25804541 chr17:80189381 SLC16A3 -0.31 -5.97 -0.31 6.08e-9 Life satisfaction; CRC cis rs10256972 0.567 rs2960835 chr7:1202963 A/G cg07308232 chr7:1071921 C7orf50 -0.46 -6.28 -0.33 1.07e-9 Longevity;Endometriosis; CRC cis rs9916302 0.904 rs8079560 chr17:37497661 C/T cg03013999 chr17:37608204 MED1 -0.48 -7.44 -0.38 8.74e-13 Glomerular filtration rate (creatinine); CRC cis rs4713118 0.869 rs9461405 chr6:27719375 G/T cg19041857 chr6:27730383 NA -0.43 -6.24 -0.33 1.33e-9 Parkinson's disease; CRC cis rs10484885 0.878 rs72921959 chr6:90591326 C/G cg13799429 chr6:90582589 CASP8AP2 -0.73 -7.7 -0.39 1.63e-13 QRS interval (sulfonylurea treatment interaction); CRC cis rs2895526 0.540 rs12412190 chr10:12714721 A/G cg00115178 chr10:12648176 CAMK1D -0.39 -6.27 -0.33 1.16e-9 Headache; CRC cis rs9818758 0.607 rs35060561 chr3:49255503 T/C cg00383909 chr3:49044727 WDR6 1.07 10.52 0.5 1.69e-22 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; CRC cis rs6860806 0.507 rs2631362 chr5:131707293 A/G cg20512303 chr5:131592959 PDLIM4 -0.37 -6.29 -0.33 1.02e-9 Breast cancer; CRC cis rs765787 0.530 rs11634794 chr15:45534492 A/C cg24006582 chr15:45444508 DUOX1 -0.54 -8.33 -0.42 2.16e-15 Uric acid levels; CRC cis rs10752881 0.809 rs3738829 chr1:183113862 C/T ch.1.3577855R chr1:183094577 LAMC1 0.83 14.65 0.63 9.3e-38 Colorectal cancer; CRC cis rs11650494 0.908 rs117853079 chr17:47421593 G/C cg08112188 chr17:47440006 ZNF652 1.26 11.71 0.54 1.03e-26 Prostate cancer; CRC cis rs12497850 0.864 rs4521268 chr3:49137904 G/T cg20833759 chr3:49053208 WDR6;DALRD3 0.5 8.11 0.41 9.97e-15 Parkinson's disease; CRC trans rs2243480 1.000 rs35396113 chr7:65495461 C/T cg10756647 chr7:56101905 PSPH 0.75 7.83 0.4 6.82e-14 Diabetic kidney disease; CRC cis rs6570726 0.935 rs419847 chr6:145827278 A/G cg23711669 chr6:146136114 FBXO30 0.68 12.04 0.55 6.41e-28 Lobe attachment (rater-scored or self-reported); CRC trans rs9858542 0.953 rs11713474 chr3:49611457 A/G cg21665057 chr3:196295764 WDR53;FBXO45 -0.72 -9.83 -0.48 3.74e-20 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC trans rs1814175 0.781 rs28681334 chr11:50051177 C/T cg15704280 chr7:45808275 SEPT13 -0.97 -19.11 -0.73 2.72e-55 Height; CRC cis rs1707322 0.752 rs28719889 chr1:46202283 C/T cg03146154 chr1:46216737 IPP 0.68 9.86 0.48 2.94e-20 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs2204008 0.714 rs11520135 chr12:38114863 C/T cg26384229 chr12:38710491 ALG10B 0.69 9.0 0.44 1.88e-17 Bladder cancer; CRC cis rs9818758 0.607 rs34823813 chr3:49749976 G/A cg01304814 chr3:48885189 PRKAR2A 0.82 6.18 0.32 1.94e-9 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; CRC cis rs10206020 0.885 rs13411553 chr2:1574018 A/G cg26248373 chr2:1572462 NA -0.82 -12.56 -0.57 7.9e-30 IgG glycosylation; CRC cis rs60843830 0.661 rs11674325 chr2:105517 C/T cg00108164 chr2:264199 ACP1;SH3YL1 0.41 5.72 0.3 2.4e-8 Spherical equivalent (joint analysis main effects and education interaction); CRC cis rs6838801 0.857 rs903044 chr4:77578750 A/G cg17476223 chr4:77663285 SHROOM3 0.42 5.67 0.3 3.14e-8 Cleft lip with or without cleft palate; CRC cis rs12701220 0.689 rs6973645 chr7:1112246 C/T cg02733842 chr7:1102375 C7orf50 -0.91 -11.53 -0.54 4.78e-26 Bronchopulmonary dysplasia; CRC trans rs925098 0.577 rs2724470 chr4:17996046 A/G cg06009330 chr2:70485380 PCYOX1 -0.42 -6.34 -0.33 7.76e-10 Birth weight;Height; CRC cis rs4713118 0.824 rs9468223 chr6:27740666 C/T cg12172441 chr6:28176163 NA 0.56 7.24 0.37 3.11e-12 Parkinson's disease; CRC cis rs644799 1.000 rs557079 chr11:95530125 C/G cg25622487 chr11:95524042 FAM76B;CEP57 0.76 11.83 0.55 3.79e-27 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs4713118 0.824 rs13211701 chr6:27750079 T/C cg02683197 chr6:28174875 NA 0.66 8.59 0.43 3.46e-16 Parkinson's disease; CRC cis rs7044106 0.762 rs3904197 chr9:123480378 C/T cg09586646 chr9:123605570 PSMD5;LOC253039 0.62 9.2 0.45 4.38e-18 Hip circumference adjusted for BMI; CRC cis rs7223966 1.000 rs8067064 chr17:61825984 A/C cg05941027 chr17:61774174 LIMD2 0.37 6.56 0.34 2.11e-10 Hip circumference adjusted for BMI;Body mass index; CRC cis rs9796 0.870 rs2412572 chr15:41264426 G/C cg18705301 chr15:41695430 NDUFAF1 0.34 5.71 0.3 2.54e-8 Menopause (age at onset); CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg27284088 chr4:84031130 PLAC8 0.47 6.23 0.32 1.4e-9 Thyroid stimulating hormone; CRC cis rs3857536 0.785 rs1935895 chr6:66936606 T/G cg07460842 chr6:66804631 NA -0.43 -5.81 -0.3 1.48e-8 Blood trace element (Cu levels); CRC cis rs11628318 0.614 rs7154538 chr14:103068112 A/G cg12046867 chr14:103022105 NA -0.73 -8.78 -0.44 9.15e-17 Platelet count; CRC cis rs9381040 1.000 rs2093395 chr6:41155026 C/G cg04346459 chr6:41068666 NFYA;LOC221442 0.42 5.91 0.31 8.4e-9 Alzheimer's disease (late onset); CRC cis rs3849570 0.533 rs6809793 chr3:81990089 C/T cg07356753 chr3:81810745 GBE1 -0.48 -6.4 -0.33 5.35e-10 Waist circumference;Body mass index; CRC trans rs61931739 0.534 rs2087128 chr12:34000173 T/C cg26384229 chr12:38710491 ALG10B 0.46 6.2 0.32 1.68e-9 Morning vs. evening chronotype; CRC cis rs863345 0.604 rs4313395 chr1:158505135 C/T cg12129480 chr1:158549410 OR10X1 -0.3 -6.27 -0.33 1.12e-9 Pneumococcal bacteremia; CRC cis rs7412746 0.658 rs2275235 chr1:150730279 A/G cg18016565 chr1:150552671 MCL1 0.44 6.06 0.32 3.76e-9 Melanoma; CRC cis rs6951245 0.554 rs58210047 chr7:1149381 G/A cg24642844 chr7:1081250 C7orf50 -0.51 -6.51 -0.34 2.82e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs11122272 0.735 rs2739509 chr1:231526765 C/T cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.55 -8.18 -0.41 6.23e-15 Hemoglobin concentration; CRC cis rs9311676 0.656 rs6775710 chr3:58336201 A/G cg06643156 chr3:58380774 PXK -0.44 -6.66 -0.34 1.15e-10 Systemic lupus erythematosus; CRC cis rs10484885 0.818 rs117562849 chr6:90249804 A/G cg13799429 chr6:90582589 CASP8AP2 -0.69 -6.98 -0.36 1.62e-11 QRS interval (sulfonylurea treatment interaction); CRC cis rs28386778 0.704 rs1051688 chr17:62006433 G/C cg06873352 chr17:61820015 STRADA -0.54 -8.98 -0.44 2.2e-17 Prudent dietary pattern; CRC cis rs10979 1.000 rs12215667 chr6:143893213 T/C cg25407410 chr6:143891975 LOC285740 -0.83 -13.72 -0.6 3.57e-34 Hypospadias; CRC cis rs7605827 0.930 rs6716384 chr2:15608210 A/G cg19274914 chr2:15703543 NA 0.39 5.9 0.31 8.83e-9 Educational attainment (years of education); CRC cis rs4713118 0.824 rs9468229 chr6:27750086 G/A cg12172441 chr6:28176163 NA 0.54 7.07 0.36 9.53e-12 Parkinson's disease; CRC cis rs9807989 0.811 rs11688568 chr2:102969949 C/T cg03938978 chr2:103052716 IL18RAP 0.37 5.97 0.31 6.2e-9 Asthma; CRC cis rs2980439 0.846 rs2980437 chr8:8094763 C/T cg14979609 chr8:8086686 FLJ10661 0.37 6.05 0.32 4.03e-9 Neuroticism; CRC cis rs769267 0.965 rs12977937 chr19:19429975 C/G cg02546618 chr19:19431379 KIAA0892;SF4 0.48 6.67 0.34 1.12e-10 Tonsillectomy; CRC cis rs10751667 0.666 rs7934963 chr11:957220 C/T cg01483505 chr11:975446 AP2A2 0.42 6.88 0.35 3.01e-11 Alzheimer's disease (late onset); CRC cis rs9976767 0.792 rs883869 chr21:43844840 T/C cg23042151 chr21:43824109 UBASH3A -0.36 -6.33 -0.33 7.88e-10 Type 1 diabetes; CRC cis rs7901135 1.000 rs7902062 chr10:60586473 C/T cg23799393 chr10:60588674 BICC1 0.36 5.66 0.3 3.33e-8 Morning vs. evening chronotype; CRC cis rs10504229 0.775 rs10504228 chr8:58162053 T/G cg20607798 chr8:58055168 NA 0.47 5.77 0.3 1.81e-8 Developmental language disorder (linguistic errors); CRC cis rs7589728 0.563 rs79892776 chr2:88470593 G/A cg18490616 chr2:88469792 THNSL2 0.58 5.84 0.31 1.28e-8 Plasma clusterin levels; CRC cis rs2032447 0.736 rs115810 chr6:25975883 G/C cg18357526 chr6:26021779 HIST1H4A 0.79 11.82 0.55 4.23e-27 Intelligence (multi-trait analysis); CRC cis rs11098499 0.754 rs1814813 chr4:120258207 G/T cg09307838 chr4:120376055 NA -0.65 -9.97 -0.48 1.23e-20 Corneal astigmatism; CRC cis rs12135062 0.851 rs2651925 chr1:3101863 C/G cg00254258 chr1:3105189 PRDM16 0.53 9.1 0.45 9.11e-18 Migraine; CRC cis rs3617 0.539 rs9825369 chr3:52953311 T/C cg15147215 chr3:52552868 STAB1 0.45 7.5 0.38 6.06e-13 Red blood cell count;Autism spectrum disorder or schizophrenia; CRC cis rs2243480 1.000 rs160633 chr7:65528228 T/C cg12463550 chr7:65579703 CRCP 0.7 6.61 0.34 1.59e-10 Diabetic kidney disease; CRC cis rs2976388 0.590 rs3758082 chr8:143824483 A/G cg24046110 chr8:143859143 LYNX1 -0.43 -6.91 -0.36 2.48e-11 Urinary tract infection frequency; CRC cis rs12523822 0.957 rs1402572 chr6:154965837 A/G cg20019720 chr6:154832845 CNKSR3 0.27 5.77 0.3 1.85e-8 Diabetic kidney disease; CRC cis rs9491140 0.539 rs12529386 chr6:124678200 A/G cg05308643 chr6:124982296 NKAIN2 0.49 6.91 0.36 2.54e-11 Neuroticism; CRC cis rs7692995 1.000 rs7671110 chr4:17874089 C/T cg08925142 chr4:18023851 LCORL -0.53 -5.85 -0.31 1.16e-8 Height; CRC cis rs7178572 1.000 rs8034133 chr15:77763712 C/G cg22256960 chr15:77711686 NA -0.7 -10.84 -0.51 1.34e-23 Type 2 diabetes; CRC cis rs1153858 0.887 rs7171163 chr15:45636395 A/C cg14582100 chr15:45693742 SPATA5L1 0.27 5.77 0.3 1.8e-8 Homoarginine levels; CRC cis rs1865760 0.865 rs9467651 chr6:25958257 C/G cg16482183 chr6:26056742 HIST1H1C 0.54 7.99 0.4 2.27e-14 Height; CRC cis rs1218582 0.772 rs6699043 chr1:154913021 T/C cg16680214 chr1:154839983 KCNN3 -0.45 -8.77 -0.44 9.88e-17 Prostate cancer; CRC cis rs11148252 0.766 rs74697307 chr13:52897573 C/T cg02158880 chr13:53174818 NA -0.44 -6.41 -0.33 5.12e-10 Lewy body disease; CRC trans rs916888 0.821 rs70600 chr17:44860021 C/T cg23590916 chr17:43697445 MGC57346 0.59 6.2 0.32 1.73e-9 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs12142240 0.698 rs7525309 chr1:46809025 G/T cg00530320 chr1:46809349 NSUN4 0.58 7.98 0.4 2.46e-14 Menopause (age at onset); CRC trans rs11661542 0.967 rs11082043 chr18:20222985 C/G cg21945992 chr3:48956913 ARIH2;C3orf71 -0.44 -6.45 -0.34 4.11e-10 Intracranial aneurysm; CRC cis rs5750830 0.649 rs4337572 chr22:39800704 C/G cg25956985 chr22:39795188 MAP3K7IP1 -0.42 -6.17 -0.32 1.98e-9 Intelligence (multi-trait analysis); CRC cis rs929596 1.000 rs929596 chr2:234674476 A/G cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.74 -10.73 -0.51 3.09e-23 Total bilirubin levels in HIV-1 infection; CRC cis rs7538876 1.000 rs2526829 chr1:17728231 A/G cg07965774 chr1:17746286 RCC2 0.3 5.74 0.3 2.14e-8 Basal cell carcinoma; CRC cis rs769267 0.965 rs4808200 chr19:19554803 C/T cg02546618 chr19:19431379 KIAA0892;SF4 0.45 6.01 0.31 4.94e-9 Tonsillectomy; CRC cis rs13108904 0.967 rs4974582 chr4:1279687 C/T cg05665937 chr4:1216051 CTBP1 0.4 5.75 0.3 1.99e-8 Obesity-related traits; CRC trans rs2303319 0.504 rs62188988 chr2:162531068 T/C cg07195197 chr16:1662150 IFT140 -0.71 -6.29 -0.33 9.86e-10 Cognitive function; CRC cis rs6500602 0.702 rs6500605 chr16:4502410 C/T cg14951292 chr16:4525986 HMOX2;NMRAL1 0.6 9.4 0.46 9.31e-19 Schizophrenia; CRC trans rs2797160 0.935 rs60515555 chr6:126000638 T/G cg05039488 chr6:79577232 IRAK1BP1 -0.5 -7.55 -0.38 4.4e-13 Endometrial cancer; CRC cis rs17234274 0.644 rs10833972 chr11:23219904 C/A cg05245346 chr11:23248277 NA 0.35 5.75 0.3 2.03e-8 Cancer; CRC cis rs7712401 0.791 rs10063253 chr5:122128711 T/C cg18764291 chr5:122110994 SNX2 0.41 6.63 0.34 1.37e-10 Mean platelet volume; CRC cis rs13082711 0.911 rs35904501 chr3:27443317 T/C cg02860705 chr3:27208620 NA 0.61 8.67 0.43 2e-16 Systolic blood pressure;Diastolic blood pressure;Blood pressure; CRC cis rs6662572 1.000 rs56251392 chr1:46210829 C/T cg08644498 chr1:46502608 NA 0.45 6.31 0.33 8.91e-10 Blood protein levels; CRC cis rs370915 1.000 rs370915 chr4:187818256 C/G cg19519643 chr4:187840862 NA -0.44 -6.62 -0.34 1.42e-10 Gout; CRC cis rs2976388 0.590 rs13254346 chr8:143823863 G/C cg24046110 chr8:143859143 LYNX1 -0.43 -6.91 -0.36 2.48e-11 Urinary tract infection frequency; CRC cis rs9322193 0.962 rs9689242 chr6:150109106 T/C cg13206674 chr6:150067644 NUP43 0.57 8.14 0.41 8.29e-15 Lung cancer; CRC cis rs951366 0.617 rs823080 chr1:205789282 G/A cg14159672 chr1:205819179 PM20D1 0.94 15.63 0.65 1.48e-41 Menarche (age at onset); CRC cis rs7827545 0.960 rs1372661 chr8:135566859 A/G cg07299736 chr8:135490787 ZFAT -0.38 -6.42 -0.33 4.65e-10 Hypertension (SNP x SNP interaction); CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg05370860 chr19:10514434 MIR1181;CDC37 0.45 6.11 0.32 2.87e-9 Anxiety disorder; CRC cis rs651907 0.557 rs7645391 chr3:101361506 C/G cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.64 8.59 0.43 3.52e-16 Colorectal cancer; CRC cis rs7412746 0.658 rs12405726 chr1:150956128 G/A cg18016565 chr1:150552671 MCL1 0.45 6.28 0.33 1.06e-9 Melanoma; CRC cis rs2836974 0.897 rs2836929 chr21:40543811 T/C cg11644478 chr21:40555479 PSMG1 0.82 12.67 0.57 3.15e-30 Cognitive function; CRC trans rs1814175 0.616 rs10839388 chr11:49842603 C/T cg11707556 chr5:10655725 ANKRD33B -0.5 -9.44 -0.46 7.26e-19 Height; CRC cis rs7949030 0.591 rs35156678 chr11:62369881 G/A cg11742103 chr11:62369870 EML3;MTA2 0.62 11.71 0.54 1e-26 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; CRC cis rs10504229 0.679 rs7813252 chr8:58136389 C/G cg24829409 chr8:58192753 C8orf71 -0.54 -7.91 -0.4 3.85e-14 Developmental language disorder (linguistic errors); CRC cis rs172166 0.637 rs1071893 chr6:28167635 G/C cg03623178 chr6:28175578 NA 0.86 13.64 0.6 7.14e-34 Cardiac Troponin-T levels; CRC cis rs9733 0.596 rs72702552 chr1:150677462 G/A cg10589385 chr1:150898437 SETDB1 0.3 6.24 0.33 1.34e-9 Tonsillectomy; CRC cis rs4819052 0.851 rs2838844 chr21:46670733 A/C cg19498844 chr21:46707878 POFUT2;LOC642852 0.74 10.69 0.51 4.32e-23 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs11155671 0.530 rs9371542 chr6:150213085 A/T cg07701084 chr6:150067640 NUP43 0.54 7.65 0.39 2.24e-13 Testicular germ cell tumor; CRC trans rs11098499 0.738 rs28408407 chr4:120376030 C/G cg25214090 chr10:38739885 LOC399744 0.65 10.42 0.5 3.58e-22 Corneal astigmatism; CRC cis rs2463822 1.000 rs951677 chr11:62107249 G/C cg06239285 chr11:62104954 ASRGL1 1.06 11.6 0.54 2.58e-26 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs1395 0.744 rs7600932 chr2:27474869 G/A cg23587288 chr2:27483067 SLC30A3 -0.4 -6.74 -0.35 7.29e-11 Blood metabolite levels; CRC cis rs1499614 0.901 rs2178742 chr7:66197799 G/A cg25985355 chr7:65971099 NA -0.51 -5.8 -0.3 1.54e-8 Gout; CRC cis rs68170813 0.605 rs75659533 chr7:107134987 A/G cg02696742 chr7:106810147 HBP1 -0.59 -6.2 -0.32 1.69e-9 Coronary artery disease; CRC cis rs3768617 0.811 rs12144261 chr1:183014148 A/G ch.1.3577855R chr1:183094577 LAMC1 0.6 8.88 0.44 4.51e-17 Fuchs's corneal dystrophy; CRC cis rs9303401 0.614 rs56284918 chr17:57178838 A/G cg10487724 chr17:56770010 TEX14;RAD51C 0.69 8.54 0.43 5.13e-16 Cognitive test performance; CRC cis rs17270561 0.609 rs7450798 chr6:25719280 T/A cg16482183 chr6:26056742 HIST1H1C 0.74 9.49 0.46 5.01e-19 Iron status biomarkers; CRC cis rs7677751 0.806 rs7673984 chr4:55088761 C/T cg17187183 chr4:55093834 PDGFRA 0.54 7.6 0.39 3.13e-13 Corneal astigmatism; CRC cis rs4253772 0.550 rs9615951 chr22:46728056 C/A cg03482458 chr22:46692211 CN5H6.4;GTSE1 0.48 5.71 0.3 2.49e-8 LDL cholesterol;Cholesterol, total; CRC cis rs73200209 0.744 rs61939700 chr12:116570921 T/C cg01776926 chr12:116560359 MED13L -0.57 -6.35 -0.33 7.32e-10 Total body bone mineral density; CRC cis rs1904096 0.506 rs7439869 chr4:95173779 T/C cg11021082 chr4:95130006 SMARCAD1 -0.5 -7.32 -0.37 1.92e-12 Type 2 diabetes; CRC cis rs447 0.806 rs2527037 chr7:83716429 C/T cg22846510 chr7:83753280 SEMA3A -0.54 -6.59 -0.34 1.76e-10 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs9486719 1.000 rs10872018 chr6:97026429 G/A cg18709589 chr6:96969512 KIAA0776 -0.52 -5.85 -0.31 1.21e-8 Migraine;Coronary artery disease; CRC cis rs11608355 0.545 rs7969313 chr12:109907303 A/G cg05360138 chr12:110035743 NA 0.77 8.61 0.43 3.16e-16 Neuroticism; CRC cis rs916888 0.821 rs199504 chr17:44861003 C/T cg01570182 chr17:44337453 NA -1.08 -12.8 -0.58 1.02e-30 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC trans rs2727020 0.731 rs10450572 chr11:49281073 T/C cg11707556 chr5:10655725 ANKRD33B 0.35 6.41 0.33 5.17e-10 Coronary artery disease; CRC cis rs1005277 0.541 rs2505193 chr10:38394638 G/C cg25517755 chr10:38738941 LOC399744 -0.44 -6.44 -0.33 4.23e-10 Extrinsic epigenetic age acceleration; CRC cis rs7772486 0.846 rs7755440 chr6:146375906 T/C cg23711669 chr6:146136114 FBXO30 0.69 12.05 0.55 5.97e-28 Lobe attachment (rater-scored or self-reported); CRC cis rs6496667 0.865 rs7163130 chr15:90883937 C/G cg04176472 chr15:90893244 GABARAPL3 0.56 6.49 0.34 3.13e-10 Rheumatoid arthritis; CRC cis rs6831352 0.589 rs1133483 chr4:100023923 G/C cg12011299 chr4:100065546 ADH4 0.63 15.69 0.65 8.52e-42 Alcohol dependence; CRC cis rs6541297 0.887 rs4846906 chr1:230284257 C/A cg20703242 chr1:230279135 GALNT2 0.51 6.78 0.35 5.59e-11 Coronary artery disease; CRC cis rs7191700 0.674 rs12597893 chr16:11426331 A/G cg00044050 chr16:11439710 C16orf75 0.55 8.19 0.41 6.03e-15 Multiple sclerosis; CRC cis rs34779708 0.931 rs4934731 chr10:35431636 T/C cg03585969 chr10:35415529 CREM 0.56 7.55 0.38 4.32e-13 Inflammatory bowel disease;Crohn's disease; CRC cis rs6460942 0.915 rs6945067 chr7:12444731 A/C cg06484146 chr7:12443880 VWDE -0.8 -8.59 -0.43 3.55e-16 Coronary artery disease; CRC cis rs2932538 0.922 rs12406906 chr1:113117900 G/T cg22162597 chr1:113214053 CAPZA1 -0.71 -10.11 -0.49 4.23e-21 Systolic blood pressure;Diastolic blood pressure;Hypertension;Blood pressure; CRC cis rs17270561 0.779 rs12210620 chr6:25884785 T/C cg16482183 chr6:26056742 HIST1H1C 0.88 11.31 0.53 2.93e-25 Iron status biomarkers; CRC cis rs728616 0.558 rs2880599 chr10:82164435 A/G cg05935833 chr10:81318306 SFTPA2 -0.58 -6.97 -0.36 1.74e-11 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs1799949 0.827 rs74252763 chr17:41402020 C/T cg19454999 chr17:41278357 BRCA1;NBR2 0.53 8.17 0.41 6.94e-15 Menopause (age at onset); CRC cis rs7630877 0.719 rs73057366 chr3:179672470 C/G cg18765712 chr3:179670323 PEX5L 0.5 7.18 0.37 4.82e-12 Type 2 diabetes; CRC cis rs9916302 0.904 rs8077104 chr17:37530510 A/G cg15445000 chr17:37608096 MED1 -0.44 -9.91 -0.48 1.93e-20 Glomerular filtration rate (creatinine); CRC cis rs7408868 0.764 rs12610803 chr19:15260682 A/C cg14696996 chr19:15285081 NOTCH3 1.0 9.03 0.45 1.47e-17 Pulse pressure; CRC cis rs57221529 0.766 rs12521988 chr5:556421 C/T cg09021430 chr5:549028 NA -0.72 -8.17 -0.41 6.5e-15 Lung disease severity in cystic fibrosis; CRC trans rs12699921 0.632 rs2723572 chr7:17888587 T/C cg02066331 chr6:17282778 RBM24 -0.35 -6.12 -0.32 2.65e-9 Fibrinogen levels; CRC cis rs3785574 0.962 rs4968660 chr17:61792221 G/A cg11494091 chr17:61959527 GH2 0.37 5.71 0.3 2.47e-8 Height; CRC cis rs9311474 0.607 rs13076398 chr3:52573096 G/A cg18404041 chr3:52824283 ITIH1 -0.36 -7.33 -0.37 1.77e-12 Electroencephalogram traits; CRC cis rs6854137 0.967 rs10033898 chr4:169734457 A/G cg20607169 chr4:169750834 PALLD -0.44 -7.02 -0.36 1.28e-11 Vein graft stenosis in coronary artery bypass grafting; CRC cis rs2242116 0.796 rs4683296 chr3:46973820 G/C cg27129171 chr3:47204927 SETD2 -0.63 -9.14 -0.45 6.63e-18 Birth weight; CRC cis rs12681288 0.712 rs2600488 chr8:1021266 A/C cg04851639 chr8:1020857 NA -0.35 -7.25 -0.37 2.95e-12 Schizophrenia; CRC cis rs365302 1.000 rs509648 chr6:159650978 A/G cg14500486 chr6:159655392 FNDC1 0.43 6.61 0.34 1.55e-10 Coronary heart disease; CRC cis rs6693567 0.545 rs1260391 chr1:150373077 T/C cg15654264 chr1:150340011 RPRD2 0.43 6.49 0.34 3.17e-10 Migraine; CRC cis rs13108904 0.934 rs13115173 chr4:1316824 T/C cg16405210 chr4:1374714 KIAA1530 -0.42 -5.74 -0.3 2.17e-8 Obesity-related traits; CRC cis rs8058578 1.000 rs8058578 chr16:30726248 C/T cg02466173 chr16:30829666 NA -0.81 -12.75 -0.58 1.54e-30 Multiple myeloma; CRC cis rs68170813 0.559 rs3801958 chr7:106961139 C/T cg02696742 chr7:106810147 HBP1 -0.59 -6.5 -0.34 2.89e-10 Coronary artery disease; CRC cis rs6662572 0.737 rs6674105 chr1:46301379 G/T cg08644498 chr1:46502608 NA -0.44 -6.97 -0.36 1.74e-11 Blood protein levels; CRC cis rs10489525 0.528 rs360604 chr1:115390019 G/A cg12756093 chr1:115239321 AMPD1 0.52 6.8 0.35 5.06e-11 Autism; CRC cis rs1799949 1.000 rs1399323 chr17:41332330 T/C cg19454999 chr17:41278357 BRCA1;NBR2 0.55 8.66 0.43 2.12e-16 Menopause (age at onset); CRC cis rs9435341 0.860 rs12406721 chr1:107563243 G/T cg14671364 chr1:107599128 PRMT6 0.51 6.78 0.35 5.5e-11 Facial morphology (factor 21, depth of nasal alae); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg22199361 chr20:5081567 C20orf30 0.41 6.27 0.33 1.16e-9 Liver disease severity in Alagille syndrome; CRC cis rs7926971 0.598 rs4288736 chr11:12652968 A/G cg25843174 chr11:12811716 TEAD1 0.32 5.62 0.3 4e-8 Height; CRC cis rs6867032 1.000 rs4975796 chr5:2015520 A/T cg26168224 chr5:2018326 NA -1.02 -18.1 -0.71 2.59e-51 Gut microbiome composition (winter); CRC cis rs1008375 0.966 rs6813375 chr4:17649499 T/G cg04450456 chr4:17643702 FAM184B 0.37 5.88 0.31 9.91e-9 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs1218582 0.772 rs10796935 chr1:154891363 G/T cg09359103 chr1:154839909 KCNN3 -0.71 -12.61 -0.57 5.17e-30 Prostate cancer; CRC cis rs6534441 0.824 rs6856045 chr4:125457662 T/C cg21609808 chr4:125404261 NA 0.38 5.75 0.3 2.07e-8 Major depressive disorder; CRC cis rs6496667 0.779 rs6496670 chr15:90949480 A/G cg04176472 chr15:90893244 GABARAPL3 0.61 7.82 0.4 7.34e-14 Rheumatoid arthritis; CRC cis rs3008870 0.755 rs2065002 chr1:67487119 A/C cg08660285 chr1:67390436 MIER1;WDR78 -0.51 -7.04 -0.36 1.09e-11 Lymphocyte percentage of white cells; CRC cis rs78456975 0.506 rs10167704 chr2:1571037 G/C cg12573674 chr2:1569213 NA -0.82 -10.94 -0.52 5.91e-24 Placebo response in major depressive disorder (% change in symptom score); CRC cis rs4665809 0.941 rs6735145 chr2:26270302 T/C cg25036284 chr2:26402008 FAM59B -0.46 -6.02 -0.32 4.57e-9 Gut microbiome composition (summer); CRC cis rs7927771 0.931 rs12361256 chr11:47910823 A/C cg20307385 chr11:47447363 PSMC3 -0.46 -6.33 -0.33 8.18e-10 Subjective well-being; CRC cis rs1577917 0.727 rs9444361 chr6:86400900 C/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A 0.69 9.22 0.45 3.61e-18 Response to antipsychotic treatment; CRC cis rs3741404 0.620 rs2236647 chr11:63964605 A/G cg06243084 chr11:63990629 FERMT3 0.45 7.14 0.37 5.98e-12 Platelet count; CRC cis rs6570726 0.935 rs407721 chr6:145871354 A/C cg23711669 chr6:146136114 FBXO30 0.71 12.45 0.57 2.02e-29 Lobe attachment (rater-scored or self-reported); CRC cis rs4285028 0.948 rs1920291 chr3:121672440 C/T cg11130432 chr3:121712080 ILDR1 -0.52 -6.75 -0.35 6.81e-11 Multiple sclerosis; CRC cis rs9549367 0.773 rs9549717 chr13:113908826 A/G cg18105134 chr13:113819100 PROZ -0.75 -10.98 -0.52 4.09e-24 Platelet distribution width; CRC cis rs7772486 0.875 rs2814869 chr6:146315509 G/A cg23711669 chr6:146136114 FBXO30 0.67 11.4 0.53 1.37e-25 Lobe attachment (rater-scored or self-reported); CRC cis rs9435341 0.896 rs1730850 chr1:107597988 C/T cg09367891 chr1:107599246 PRMT6 -0.7 -10.47 -0.5 2.41e-22 Facial morphology (factor 21, depth of nasal alae); CRC cis rs7809950 1.000 rs2894475 chr7:107262558 A/T cg23024343 chr7:107201750 COG5 -0.58 -8.61 -0.43 3.1e-16 Coronary artery disease; CRC cis rs654950 0.806 rs1815257 chr1:42041479 A/C cg06885757 chr1:42089581 HIVEP3 -0.51 -8.79 -0.44 8.17e-17 Airway imaging phenotypes; CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg00300090 chr3:4345167 SETMAR 0.38 6.06 0.32 3.64e-9 Obesity-related traits; CRC cis rs1799949 1.000 rs33920795 chr17:41329010 A/G cg05368731 chr17:41323189 NBR1 0.69 10.45 0.5 2.95e-22 Menopause (age at onset); CRC cis rs16973500 0.808 rs112452788 chr16:71911198 C/T cg00732059 chr16:71740210 PHLPP2 -0.67 -6.89 -0.36 2.86e-11 Response to anti-TNF therapy in rheumatoid arthritis;Attention deficit hyperactivity disorder and conduct disorder; CRC cis rs6460942 1.000 rs73053527 chr7:12313008 C/A cg20607287 chr7:12443886 VWDE -0.65 -6.43 -0.33 4.41e-10 Coronary artery disease; CRC cis rs1113500 0.933 rs11185261 chr1:108638703 G/A cg06207961 chr1:108661230 NA 0.39 5.75 0.3 2e-8 Growth-regulated protein alpha levels; CRC cis rs4604732 0.631 rs74154676 chr1:247625894 T/C cg12754571 chr1:247694271 LOC148824;OR2C3 0.41 5.78 0.3 1.74e-8 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CRC cis rs3785574 0.927 rs2854160 chr17:61977248 C/T cg23090583 chr17:61904693 PSMC5;FTSJ3 0.64 8.91 0.44 3.67e-17 Height; CRC cis rs898097 0.578 rs9906163 chr17:80908174 T/C cg15369054 chr17:80825471 TBCD -0.36 -6.02 -0.31 4.68e-9 Breast cancer; CRC cis rs9359856 0.564 rs17292768 chr6:90379311 T/C cg13799429 chr6:90582589 CASP8AP2 -0.72 -7.64 -0.39 2.4e-13 Bipolar disorder; CRC cis rs6834538 0.558 rs13120366 chr4:113394085 T/C cg10021238 chr4:113569128 MIR367;LARP7 -0.38 -5.79 -0.3 1.67e-8 Free thyroxine concentration; CRC cis rs10540 1.000 rs117339389 chr11:505025 T/A cg15790184 chr11:494944 RNH1 0.62 6.26 0.33 1.22e-9 Body mass index; CRC cis rs10504229 0.906 rs111838497 chr8:58185620 A/C cg05313129 chr8:58192883 C8orf71 -0.47 -6.99 -0.36 1.49e-11 Developmental language disorder (linguistic errors); CRC cis rs34864796 0.547 rs200476 chr6:27768348 A/T cg15786705 chr6:28176104 NA 0.48 5.72 0.3 2.44e-8 Lung function (FEV1);Lung function (FEV1/FVC);Lung function (FVC); CRC cis rs7809950 1.000 rs12667527 chr7:107086969 T/C cg23024343 chr7:107201750 COG5 -0.62 -8.79 -0.44 8.72e-17 Coronary artery disease; CRC cis rs4713118 0.568 rs9468213 chr6:27706180 G/A cg25164649 chr6:28176230 NA 0.52 7.41 0.38 1.07e-12 Parkinson's disease; CRC cis rs6121246 0.609 rs6060627 chr20:30262159 C/T cg13852791 chr20:30311386 BCL2L1 0.71 13.94 0.61 4.92e-35 Mean corpuscular hemoglobin; CRC cis rs7107174 1.000 rs11601161 chr11:78073280 A/G cg02023728 chr11:77925099 USP35 0.48 7.29 0.37 2.35e-12 Testicular germ cell tumor; CRC cis rs1799949 1.000 rs11653231 chr17:41331460 G/A cg23758822 chr17:41437982 NA 0.79 13.57 0.6 1.3e-33 Menopause (age at onset); CRC cis rs7659604 1.000 rs35224452 chr4:122664677 C/T cg06713675 chr4:122721982 EXOSC9 -0.38 -6.25 -0.33 1.24e-9 Type 2 diabetes; CRC cis rs7202877 0.610 rs3784936 chr16:75337583 C/G cg03315344 chr16:75512273 CHST6 0.51 5.85 0.31 1.18e-8 Type 2 diabetes;Type 1 diabetes; CRC cis rs11608355 0.545 rs6606721 chr12:109891999 G/A cg05360138 chr12:110035743 NA 0.77 8.7 0.43 1.65e-16 Neuroticism; CRC cis rs2842992 0.789 rs7765490 chr6:160204326 C/T cg19482086 chr6:160211437 TCP1;MRPL18 0.71 9.46 0.46 6.23e-19 Age-related macular degeneration (geographic atrophy); CRC cis rs1552244 0.935 rs66493421 chr3:10092569 G/A cg13047869 chr3:10149882 C3orf24 0.52 6.27 0.33 1.15e-9 Alzheimer's disease; CRC cis rs2949837 0.581 rs2960437 chr7:45977352 G/A cg04727332 chr7:45960243 IGFBP3 0.36 5.63 0.3 3.77e-8 Sitting height ratio; CRC cis rs600231 0.542 rs34527830 chr11:65240863 G/A cg17120908 chr11:65337727 SSSCA1 -0.68 -7.56 -0.38 4.09e-13 Bone mineral density; CRC cis rs6968419 0.755 rs6967695 chr7:115896049 G/A cg02561103 chr7:115862891 TES -0.43 -6.47 -0.34 3.48e-10 Intraocular pressure; CRC cis rs7666738 0.753 rs6826709 chr4:98714553 C/G cg05340658 chr4:99064831 C4orf37 0.57 8.56 0.43 4.33e-16 Colonoscopy-negative controls vs population controls; CRC cis rs765787 0.530 rs4331289 chr15:45515338 C/T cg24006582 chr15:45444508 DUOX1 -0.57 -8.73 -0.43 1.27e-16 Uric acid levels; CRC cis rs35306767 0.903 rs12250937 chr10:900209 C/T cg20503657 chr10:835505 NA 0.86 10.95 0.52 5.46e-24 Eosinophil percentage of granulocytes; CRC cis rs9326248 1.000 rs3736120 chr11:117032125 G/T cg10398005 chr11:117014888 PAFAH1B2 -0.39 -5.65 -0.3 3.49e-8 Blood protein levels; CRC cis rs12451471 0.620 rs11150846 chr17:78098520 C/T cg20811857 chr17:78079795 GAA -0.45 -6.52 -0.34 2.58e-10 Plateletcrit;Mean corpuscular hemoglobin concentration; CRC cis rs780096 0.526 rs1406295 chr2:27689700 A/G cg12648201 chr2:27665141 KRTCAP3 -0.31 -6.28 -0.33 1.05e-9 Total body bone mineral density; CRC cis rs72634501 0.716 rs67637163 chr1:39576621 T/G cg18385671 chr1:39797026 MACF1 -0.42 -5.82 -0.31 1.41e-8 HDL cholesterol; CRC cis rs6424115 0.545 rs11576333 chr1:24065770 C/T cg10978503 chr1:24200527 CNR2 -0.42 -6.13 -0.32 2.45e-9 Immature fraction of reticulocytes; CRC cis rs514406 0.861 rs554760 chr1:53266749 G/A cg27535305 chr1:53392650 SCP2 0.39 7.01 0.36 1.34e-11 Monocyte count; CRC cis rs7811142 1.000 rs7783550 chr7:99987805 A/G cg13153964 chr7:100026424 MEPCE;ZCWPW1 -1.12 -16.79 -0.68 3.95e-46 Platelet count; CRC cis rs10504229 0.683 rs1495865 chr8:58141160 T/G cg02290350 chr8:58132656 NA -0.58 -8.16 -0.41 7.29e-15 Developmental language disorder (linguistic errors); CRC cis rs10504229 0.906 rs7003276 chr8:58173089 A/T cg22535103 chr8:58192502 C8orf71 -0.79 -12.09 -0.55 4.31e-28 Developmental language disorder (linguistic errors); CRC cis rs7618915 0.547 rs13065019 chr3:52685244 T/C cg15147215 chr3:52552868 STAB1 -0.62 -10.28 -0.49 1.13e-21 Bipolar disorder; CRC cis rs9311474 0.508 rs11718420 chr3:52611413 T/C cg05573699 chr3:52720067 GNL3;PBRM1 -0.44 -6.45 -0.34 3.94e-10 Electroencephalogram traits; CRC cis rs4713118 0.581 rs200504 chr6:27785820 T/C cg06470822 chr6:28175283 NA 0.62 6.93 0.36 2.28e-11 Parkinson's disease; CRC cis rs66573146 0.831 rs11546450 chr4:7032180 G/A cg00086871 chr4:6988644 TBC1D14 0.9 7.36 0.38 1.46e-12 Granulocyte percentage of myeloid white cells; CRC cis rs6500395 1.000 rs12919520 chr16:48705760 G/C cg04672837 chr16:48644449 N4BP1 -0.45 -6.63 -0.34 1.38e-10 Response to tocilizumab in rheumatoid arthritis; CRC cis rs2070488 0.775 rs6794397 chr3:38559307 A/G cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.75 12.61 0.57 5.3e-30 Electrocardiographic conduction measures; CRC cis rs72634258 0.554 rs34020118 chr1:7895015 C/T cg26816564 chr1:7831052 VAMP3 0.94 9.94 0.48 1.61e-20 Inflammatory bowel disease; CRC cis rs7119 0.717 rs12910951 chr15:77806797 A/G cg27398640 chr15:77910606 LINGO1 -0.45 -7.78 -0.39 9.51e-14 Type 2 diabetes; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg18013306 chr15:68521911 CLN6 0.45 6.11 0.32 2.77e-9 Anxiety disorder; CRC cis rs11971779 0.688 rs8137 chr7:139104461 A/C cg07862535 chr7:139043722 LUC7L2 -0.57 -7.38 -0.38 1.29e-12 Diisocyanate-induced asthma; CRC cis rs6963495 0.818 rs73190184 chr7:105163736 C/T cg13798780 chr7:105162888 PUS7 0.68 8.08 0.41 1.27e-14 Bipolar disorder (body mass index interaction); CRC cis rs10751667 0.643 rs7942693 chr11:957832 G/A cg01483505 chr11:975446 AP2A2 0.45 7.58 0.39 3.59e-13 Alzheimer's disease (late onset); CRC cis rs1552244 1.000 rs6789156 chr3:10124120 C/T cg13047869 chr3:10149882 C3orf24 0.54 7.43 0.38 9.22e-13 Alzheimer's disease; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg02630704 chr19:13260775 IER2;STX10 0.43 5.97 0.31 5.99e-9 Response to antipsychotic treatment; CRC cis rs1862618 0.853 rs252902 chr5:56116085 A/G cg03609598 chr5:56110824 MAP3K1 -0.83 -10.43 -0.5 3.29e-22 Initial pursuit acceleration; CRC cis rs747650 0.504 rs6485726 chr11:47082122 C/A cg19486271 chr11:47235900 DDB2 -0.44 -5.86 -0.31 1.11e-8 Acne (severe); CRC cis rs2011503 1.000 rs56280531 chr19:19585788 A/C cg11584989 chr19:19387371 SF4 0.55 6.17 0.32 1.96e-9 Bipolar disorder; CRC cis rs6545883 0.894 rs12615783 chr2:61440947 T/C cg15711740 chr2:61764176 XPO1 0.43 5.74 0.3 2.2e-8 Tuberculosis; CRC cis rs798554 0.686 rs7777484 chr7:2814271 A/G cg17321639 chr7:2759063 NA -0.4 -5.79 -0.3 1.62e-8 Height; CRC cis rs56011263 0.687 rs11734460 chr4:705074 C/T cg14024328 chr4:719362 PCGF3 -0.55 -7.73 -0.39 1.32e-13 White blood cell count; CRC cis rs7474896 0.559 rs1212108 chr10:38094322 A/C cg25427524 chr10:38739819 LOC399744 -0.65 -7.95 -0.4 2.98e-14 Obesity (extreme); CRC cis rs972578 1.000 rs1071961 chr22:43349699 C/A cg01576275 chr22:43409880 NA -0.45 -7.24 -0.37 3.23e-12 Mean platelet volume; CRC trans rs7937682 1.000 rs11608122 chr11:111535105 C/T cg18187862 chr3:45730750 SACM1L -0.54 -7.61 -0.39 2.88e-13 Primary sclerosing cholangitis; CRC cis rs13108904 0.535 rs1250101 chr4:1236111 G/A cg23123621 chr4:1343375 KIAA1530 -0.36 -5.69 -0.3 2.86e-8 Obesity-related traits; CRC cis rs3020333 0.875 rs2941742 chr6:152012988 A/G cg22157087 chr6:152012887 ESR1 0.54 8.18 0.41 6.06e-15 Total body bone mineral density; CRC cis rs7487075 0.578 rs11183486 chr12:46837704 A/C cg22049899 chr12:47219821 SLC38A4 0.32 5.83 0.31 1.34e-8 Itch intensity from mosquito bite; CRC cis rs2857891 0.909 rs56261447 chr11:6939382 A/C cg17084751 chr11:6953558 ZNF215 -0.51 -5.81 -0.31 1.47e-8 Response to cytadine analogues (cytosine arabinoside); CRC cis rs11123610 0.520 rs12996655 chr2:3720900 G/A cg19052272 chr2:3704530 ALLC -0.62 -7.6 -0.39 3.05e-13 Response to inhaled corticosteroid treatment in asthma (change in FEV1); CRC cis rs12541335 0.639 rs7834182 chr8:22163112 G/A cg18135555 chr8:22132992 PIWIL2 0.41 8.1 0.41 1.08e-14 Hypertriglyceridemia; CRC cis rs2276314 0.857 rs62101402 chr18:33629435 A/G cg19628046 chr18:33552617 C18orf21 0.51 7.08 0.36 8.52e-12 Endometriosis;Drug-induced torsades de pointes; CRC cis rs9322193 0.884 rs10782312 chr6:149943805 G/T cg05861140 chr6:150128134 PCMT1 -0.36 -5.92 -0.31 8.26e-9 Lung cancer; CRC cis rs7639513 0.767 rs7617041 chr3:12709167 A/G cg23032965 chr3:12705835 RAF1 0.64 9.84 0.48 3.37e-20 Itch intensity from mosquito bite; CRC cis rs28386778 0.897 rs2727326 chr17:61923016 G/A cg07362569 chr17:61921086 SMARCD2 0.37 5.71 0.3 2.47e-8 Prudent dietary pattern; CRC cis rs3820068 0.581 rs16851841 chr1:15922713 A/G cg24675056 chr1:15929824 NA 0.48 6.52 0.34 2.66e-10 Systolic blood pressure; CRC cis rs13082711 0.911 rs2131205 chr3:27428501 A/G cg02860705 chr3:27208620 NA 0.59 8.44 0.42 1.04e-15 Systolic blood pressure;Diastolic blood pressure;Blood pressure; CRC cis rs10504229 0.683 rs17194792 chr8:58107195 A/C cg02725872 chr8:58115012 NA -0.59 -7.96 -0.4 2.85e-14 Developmental language disorder (linguistic errors); CRC cis rs9783347 0.961 rs12293544 chr11:18348581 T/C cg15585147 chr11:18324498 HPS5 0.45 6.34 0.33 7.44e-10 Pancreatic cancer; CRC cis rs8180040 0.726 rs2061197 chr3:47001350 C/T cg10298567 chr3:47292165 KIF9 0.38 5.79 0.3 1.61e-8 Colorectal cancer; CRC cis rs13064411 0.735 rs7631138 chr3:113231925 A/T cg10517650 chr3:113235015 CCDC52 -0.41 -7.26 -0.37 2.81e-12 Response to simvastatin treatment (PCSK9 protein level change); CRC cis rs941873 0.868 rs7332 chr10:81114060 G/A cg08514558 chr10:81106712 PPIF 0.36 5.79 0.3 1.65e-8 Height; CRC cis rs11997175 0.624 rs4355732 chr8:33676920 A/C cg04338863 chr8:33670619 NA 0.44 7.06 0.36 9.65e-12 Body mass index; CRC cis rs1799949 1.000 rs67060599 chr17:41255102 A/G cg05368731 chr17:41323189 NBR1 0.67 9.8 0.48 4.77e-20 Menopause (age at onset); CRC cis rs1519814 0.876 rs10955954 chr8:121108052 A/G cg22335954 chr8:121166405 COL14A1 -0.49 -6.07 -0.32 3.59e-9 Breast cancer; CRC cis rs9733 0.596 rs7412396 chr1:150666797 C/T cg15448220 chr1:150897856 SETDB1 0.41 5.97 0.31 6.2e-9 Tonsillectomy; CRC cis rs10504229 0.728 rs72650853 chr8:58151473 G/A cg24829409 chr8:58192753 C8orf71 -0.58 -7.96 -0.4 2.86e-14 Developmental language disorder (linguistic errors); CRC trans rs1979967 0.524 rs1979965 chr15:79658995 G/A cg14802097 chr12:42970349 PRICKLE1 0.52 6.06 0.32 3.66e-9 Interleukin-18 levels; CRC cis rs736408 0.609 rs13082208 chr3:52781539 T/G cg11645453 chr3:52864694 ITIH4 0.36 6.24 0.33 1.31e-9 Bipolar disorder; CRC cis rs12137294 0.866 rs1172153 chr1:205220661 T/C cg24159697 chr1:205181237 DSTYK -0.34 -6.08 -0.32 3.39e-9 Red cell distribution width; CRC cis rs1448094 0.511 rs10735486 chr12:86154352 T/A cg02569458 chr12:86230093 RASSF9 -0.47 -7.98 -0.4 2.49e-14 Major depressive disorder; CRC cis rs1865760 0.566 rs9295688 chr6:26084217 G/A cg16482183 chr6:26056742 HIST1H1C 0.52 7.5 0.38 6.17e-13 Height; CRC cis rs6570726 0.791 rs378937 chr6:145834745 C/T cg13319975 chr6:146136371 FBXO30 -0.46 -7.0 -0.36 1.42e-11 Lobe attachment (rater-scored or self-reported); CRC cis rs10504229 0.683 rs58883273 chr8:58138275 A/G cg24829409 chr8:58192753 C8orf71 -0.55 -8.03 -0.4 1.71e-14 Developmental language disorder (linguistic errors); CRC cis rs7827545 1.000 rs7008158 chr8:135565982 T/C cg07299736 chr8:135490787 ZFAT -0.37 -6.2 -0.32 1.73e-9 Hypertension (SNP x SNP interaction); CRC cis rs9649213 0.593 rs6944262 chr7:97985415 T/G cg24562669 chr7:97807699 LMTK2 0.44 7.29 0.37 2.29e-12 Prostate cancer (SNP x SNP interaction); CRC cis rs4964805 0.865 rs35371470 chr12:104203720 C/G cg02344784 chr12:104178138 NT5DC3 0.47 6.46 0.34 3.68e-10 Attention deficit hyperactivity disorder; CRC trans rs7937682 0.924 rs495460 chr11:111504777 G/A cg18187862 chr3:45730750 SACM1L 0.48 6.88 0.35 3.04e-11 Primary sclerosing cholangitis; CRC cis rs11758351 0.517 rs79958315 chr6:26221826 C/T cg21425842 chr6:26240939 HIST1H4F -0.34 -5.68 -0.3 2.98e-8 Gout;Renal underexcretion gout; CRC cis rs10504229 1.000 rs59797486 chr8:58174435 T/C cg24829409 chr8:58192753 C8orf71 -0.64 -10.9 -0.51 8.17e-24 Developmental language disorder (linguistic errors); CRC cis rs2658782 0.654 rs2248524 chr11:93255715 G/A cg15737290 chr11:93063684 CCDC67 0.51 7.77 0.39 1.04e-13 Pulmonary function decline; CRC cis rs17767392 0.881 rs12881957 chr14:71909854 C/T cg13720639 chr14:72061746 SIPA1L1 -0.55 -7.08 -0.36 9.04e-12 Mitral valve prolapse; CRC cis rs7493 1.000 rs12155103 chr7:95037131 G/A cg21856205 chr7:94953877 PON1 -0.49 -6.44 -0.33 4.12e-10 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs7119 0.700 rs2867311 chr15:77902191 A/C cg10437265 chr15:77819839 NA -0.47 -8.34 -0.42 2.01e-15 Type 2 diabetes; CRC cis rs79839061 0.610 rs11726280 chr4:864077 C/T cg07828340 chr4:882639 GAK 1.13 10.9 0.52 7.71e-24 Intelligence (multi-trait analysis); CRC cis rs10504229 1.000 rs56344560 chr8:58180626 C/G cg22535103 chr8:58192502 C8orf71 -0.79 -11.86 -0.55 2.96e-27 Developmental language disorder (linguistic errors); CRC cis rs6502050 0.723 rs8077209 chr17:80163221 A/G cg13939156 chr17:80058883 NA -0.4 -6.49 -0.34 3.1e-10 Life satisfaction; CRC cis rs4713118 0.539 rs200951 chr6:27835930 A/G cg03623178 chr6:28175578 NA 0.74 10.55 0.5 1.28e-22 Parkinson's disease; CRC cis rs3741404 0.560 rs2875748 chr11:63915537 G/A cg19465662 chr11:63993652 NUDT22;TRPT1 -0.67 -10.41 -0.5 3.88e-22 Platelet count; CRC cis rs8141797 0.901 rs4820581 chr22:24480503 G/A cg20894457 chr22:24584366 SUSD2 -0.61 -7.56 -0.38 4.14e-13 Amyotrophic lateral sclerosis;Coronary artery disease; CRC trans rs7395662 0.547 rs10769442 chr11:48765027 C/T cg21153622 chr11:89784906 NA -0.48 -7.79 -0.39 8.59e-14 HDL cholesterol; CRC cis rs28386778 0.863 rs9897229 chr17:61782325 T/C cg11494091 chr17:61959527 GH2 0.65 10.86 0.51 1.07e-23 Prudent dietary pattern; CRC cis rs644799 1.000 rs627568 chr11:95569253 A/C cg25622487 chr11:95524042 FAM76B;CEP57 0.77 12.04 0.55 6.36e-28 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs477895 1.000 rs7938380 chr11:64034866 G/A cg04317338 chr11:64019027 PLCB3 0.61 6.44 0.33 4.22e-10 Mean platelet volume; CRC cis rs1538970 1.000 rs2492840 chr1:45849792 C/A cg05343316 chr1:45956843 TESK2 0.61 8.45 0.42 9.8e-16 Platelet count; CRC cis rs1799949 0.965 rs8176198 chr17:41230537 A/T cg25072359 chr17:41440525 NA 0.5 7.78 0.39 9.69e-14 Menopause (age at onset); CRC cis rs9322193 0.962 rs9322219 chr6:150103399 C/T cg04369109 chr6:150039330 LATS1 -0.43 -6.01 -0.31 4.85e-9 Lung cancer; CRC cis rs4654899 0.627 rs667071 chr1:21045726 T/C cg02927042 chr1:21476669 EIF4G3 -0.45 -6.78 -0.35 5.71e-11 Superior frontal gyrus grey matter volume; CRC cis rs17711722 0.565 rs73372653 chr7:65442795 A/T cg02869306 chr7:64672164 INTS4L1 -0.46 -7.87 -0.4 5.22e-14 Calcium levels; CRC trans rs2303319 0.504 rs62189052 chr2:162623869 C/G cg18122310 chr12:50236657 BCDIN3D -0.73 -6.35 -0.33 7.23e-10 Cognitive function; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg24714709 chr7:95064397 PON2 0.39 6.77 0.35 5.78e-11 Liver disease severity in Alagille syndrome; CRC cis rs2120019 1.000 rs12910644 chr15:75358388 A/G cg09165964 chr15:75287851 SCAMP5 -0.84 -13.16 -0.59 4.39e-32 Blood trace element (Zn levels); CRC cis rs1153858 1.000 rs56850226 chr15:45633118 T/C cg21132104 chr15:45694354 SPATA5L1 0.59 8.62 0.43 2.92e-16 Homoarginine levels; CRC cis rs6860806 1.000 rs6860806 chr5:131640536 C/T cg09877947 chr5:131593287 PDLIM4 -0.36 -6.6 -0.34 1.66e-10 Breast cancer; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg02951021 chr12:120934296 DYNLL1 0.41 6.45 0.34 3.9e-10 Liver disease severity in Alagille syndrome; CRC cis rs11098499 0.618 rs6858383 chr4:120296772 T/C cg09307838 chr4:120376055 NA 0.71 10.93 0.52 6.41e-24 Corneal astigmatism; CRC cis rs3617 0.573 rs2336667 chr3:52916363 C/T cg18099408 chr3:52552593 STAB1 0.33 5.68 0.3 2.99e-8 Red blood cell count;Autism spectrum disorder or schizophrenia; CRC cis rs870825 0.616 rs7667409 chr4:185650941 C/T cg04058563 chr4:185651563 MLF1IP -0.73 -9.4 -0.46 9.52e-19 Blood protein levels; CRC trans rs2228479 0.850 rs62054611 chr16:89817017 T/C cg21302420 chr1:112162376 RAP1A 0.72 6.01 0.31 5.05e-9 Skin colour saturation; CRC cis rs4654899 0.733 rs6698440 chr1:21258712 C/T cg02927042 chr1:21476669 EIF4G3 -0.42 -6.52 -0.34 2.6e-10 Superior frontal gyrus grey matter volume; CRC cis rs8177253 1.000 rs8177272 chr3:133482870 C/T cg08048268 chr3:133502702 NA -0.37 -6.98 -0.36 1.64e-11 Iron status biomarkers; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg01636747 chr16:28957148 NA 0.46 6.74 0.35 6.92e-11 Liver disease severity in Alagille syndrome; CRC cis rs9486715 0.830 rs2255552 chr6:96999643 A/G cg06623918 chr6:96969491 KIAA0776 -0.99 -18.89 -0.72 2.08e-54 Headache; CRC cis rs597539 0.690 rs608810 chr11:68624118 G/C cg06112835 chr11:68658793 MRPL21 0.45 7.03 0.36 1.22e-11 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs6912958 0.535 rs242283 chr6:88030931 C/T cg12350822 chr6:88032061 C6orf162;GJB7 0.48 9.71 0.47 9.27e-20 Monocyte percentage of white cells; CRC cis rs9368481 0.645 rs10456350 chr6:26975581 A/C cg05192639 chr6:26864778 GUSBL1 0.33 6.08 0.32 3.28e-9 Autism spectrum disorder or schizophrenia; CRC cis rs1552244 0.554 rs4488814 chr3:10002400 C/T cg08888203 chr3:10149979 C3orf24 -0.5 -7.69 -0.39 1.69e-13 Alzheimer's disease; CRC cis rs1348850 0.914 rs3902850 chr2:178315899 G/A cg02961200 chr2:178257176 LOC100130691;AGPS 0.63 9.29 0.46 2.16e-18 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs8180040 0.800 rs11920354 chr3:47262246 C/A cg10298567 chr3:47292165 KIF9 0.41 6.53 0.34 2.53e-10 Colorectal cancer; CRC cis rs3804749 0.966 rs3792366 chr3:122839876 G/A cg26084141 chr3:122786895 PDIA5 0.23 6.04 0.32 4.11e-9 Plateletcrit;Mean platelet volume;Platelet count;Platelet distribution width; CRC trans rs75804782 0.520 rs34058921 chr2:239318665 C/T cg01134436 chr17:81009848 B3GNTL1 0.77 7.07 0.36 9.16e-12 Morning vs. evening chronotype;Chronotype; CRC cis rs853679 0.517 rs9348797 chr6:28137533 G/C cg21251018 chr6:28226885 NKAPL 0.48 6.17 0.32 2.02e-9 Depression; CRC cis rs9611565 0.659 rs56319767 chr22:41933837 G/A cg03806693 chr22:41940476 POLR3H -1.12 -14.83 -0.63 1.91e-38 Vitiligo; CRC cis rs7044106 0.762 rs1158553 chr9:123400974 C/G cg14255062 chr9:123606675 PSMD5;LOC253039 0.44 6.36 0.33 6.77e-10 Hip circumference adjusted for BMI; CRC cis rs2180341 0.961 rs7775493 chr6:127615000 C/A cg24812749 chr6:127587940 RNF146 0.94 13.67 0.6 5.36e-34 Breast cancer; CRC cis rs3820068 0.603 rs6429769 chr1:15968610 C/G cg24675056 chr1:15929824 NA 0.5 6.96 0.36 1.83e-11 Systolic blood pressure; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg05323904 chr16:691677 FAM195A 0.42 6.05 0.32 3.98e-9 Response to antipsychotic treatment; CRC cis rs853679 0.517 rs36078605 chr6:28078032 A/C cg06470822 chr6:28175283 NA 0.99 12.76 0.58 1.4e-30 Depression; CRC cis rs7215564 0.908 rs2316062 chr17:78663558 C/T cg09596252 chr17:78655493 RPTOR 0.56 6.11 0.32 2.76e-9 Myopia (pathological); CRC cis rs2842992 0.747 rs9365095 chr6:160192928 T/G cg19482086 chr6:160211437 TCP1;MRPL18 0.73 9.66 0.47 1.39e-19 Age-related macular degeneration (geographic atrophy); CRC cis rs3736594 0.513 rs62131882 chr2:27765480 T/C cg27432699 chr2:27873401 GPN1 0.67 8.52 0.43 5.67e-16 Fasting blood glucose;Fasting blood glucose (BMI interaction); CRC cis rs7772486 0.806 rs7740785 chr6:146171299 C/A cg13319975 chr6:146136371 FBXO30 -0.39 -5.85 -0.31 1.18e-8 Lobe attachment (rater-scored or self-reported); CRC cis rs2576037 0.901 rs2060416 chr18:44576240 G/C cg07416455 chr18:44543612 TCEB3CL;KATNAL2 0.41 6.04 0.32 4.22e-9 Personality dimensions; CRC cis rs4713118 0.516 rs7739216 chr6:28079946 G/T cg06470822 chr6:28175283 NA 1.0 13.03 0.58 1.36e-31 Parkinson's disease; CRC cis rs9916302 0.904 rs602688 chr17:37439496 C/T cg00129232 chr17:37814104 STARD3 -0.49 -7.01 -0.36 1.36e-11 Glomerular filtration rate (creatinine); CRC cis rs870825 0.616 rs877276 chr4:185621249 C/T cg04058563 chr4:185651563 MLF1IP 0.72 9.38 0.46 1.12e-18 Blood protein levels; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg21097640 chr13:28195548 POLR1D;LNX2 0.48 6.12 0.32 2.61e-9 Thyroid stimulating hormone; CRC trans rs6006893 0.935 rs8139558 chr22:45251169 C/T cg18016826 chr5:176560001 NSD1 -0.44 -5.96 -0.31 6.45e-9 Binge eating behaviour in bipolar disorder; CRC cis rs4731207 0.596 rs1871773 chr7:124674939 A/G cg23710748 chr7:124431027 NA -0.39 -6.23 -0.32 1.44e-9 Cutaneous malignant melanoma; CRC cis rs4862750 0.914 rs9998558 chr4:187874691 A/G cg07414643 chr4:187882934 NA 0.37 6.45 0.34 3.89e-10 Lobe attachment (rater-scored or self-reported); CRC cis rs67311347 0.956 rs9822870 chr3:40514890 A/C cg24209194 chr3:40518798 ZNF619 -0.43 -6.42 -0.33 4.89e-10 Renal cell carcinoma; CRC cis rs172166 0.694 rs2791332 chr6:28108788 C/T cg03623178 chr6:28175578 NA 0.79 11.53 0.54 4.47e-26 Cardiac Troponin-T levels; CRC cis rs2629540 0.847 rs12763093 chr10:126395688 C/G cg08799069 chr10:126477246 METTL10 -0.61 -7.89 -0.4 4.52e-14 Cocaine dependence; CRC cis rs6582630 0.638 rs10880620 chr12:38517467 A/G cg13010199 chr12:38710504 ALG10B -0.44 -6.23 -0.33 1.39e-9 Drug-induced liver injury (flucloxacillin); CRC cis rs7618915 0.547 rs11130323 chr3:52770277 T/C cg07507251 chr3:52567010 NT5DC2 0.4 5.65 0.3 3.52e-8 Bipolar disorder; CRC cis rs1267303 0.675 rs1745370 chr1:46982863 C/G cg25110126 chr1:46999211 NA -0.58 -8.52 -0.43 5.71e-16 Monobrow; CRC cis rs7224685 0.539 rs2054039 chr17:4014538 C/A cg11204139 chr17:3907470 NA 0.64 11.14 0.52 1.11e-24 Type 2 diabetes; CRC cis rs1267303 0.642 rs116078607 chr1:46999238 G/A cg08533674 chr1:46993347 NA -0.8 -10.42 -0.5 3.71e-22 Monobrow; CRC cis rs7107174 0.901 rs10899493 chr11:78117534 T/C cg12700464 chr11:78128424 GAB2 -0.51 -6.16 -0.32 2.1e-9 Testicular germ cell tumor; CRC cis rs12142240 0.698 rs6703669 chr1:46862555 C/T cg00530320 chr1:46809349 NSUN4 0.59 8.07 0.41 1.35e-14 Menopause (age at onset); CRC cis rs7429990 0.965 rs5016900 chr3:47822877 G/C cg11946769 chr3:48343235 NME6 0.56 6.34 0.33 7.8e-10 Educational attainment (years of education); CRC cis rs2292884 0.505 rs78063959 chr2:238428961 G/A cg14458575 chr2:238380390 NA 0.6 7.78 0.39 9.56e-14 Prostate cancer; CRC trans rs1814175 0.645 rs28441045 chr11:50048971 C/T cg11707556 chr5:10655725 ANKRD33B -0.5 -9.83 -0.48 3.72e-20 Height; CRC cis rs10504229 0.683 rs7000349 chr8:58114569 C/A cg22535103 chr8:58192502 C8orf71 -0.69 -9.23 -0.45 3.37e-18 Developmental language disorder (linguistic errors); CRC trans rs1814175 0.645 rs7928714 chr11:49887622 G/A cg15704280 chr7:45808275 SEPT13 -0.93 -16.5 -0.67 5.24e-45 Height; CRC trans rs8002861 0.727 rs9533652 chr13:44419532 A/G cg12856521 chr11:46389249 DGKZ -0.5 -8.27 -0.41 3.37e-15 Leprosy; CRC cis rs2836974 0.644 rs2836982 chr21:40689171 C/A cg17971929 chr21:40555470 PSMG1 -0.62 -9.05 -0.45 1.32e-17 Cognitive function; CRC cis rs7940866 0.740 rs7131121 chr11:130806424 A/G cg12179176 chr11:130786555 SNX19 0.64 9.23 0.45 3.35e-18 Schizophrenia; CRC cis rs1008375 0.933 rs7689101 chr4:17694034 G/A cg16339924 chr4:17578868 LAP3 0.47 6.4 0.33 5.38e-10 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs11711311 0.955 rs10934241 chr3:113394705 G/A cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.54 -6.97 -0.36 1.73e-11 IgG glycosylation; CRC cis rs1863824 0.625 rs10887598 chr10:88166160 T/A cg07322936 chr10:88137208 NA -0.62 -8.55 -0.43 4.57e-16 Schizophrenia; CRC cis rs6424115 1.000 rs12031592 chr1:24127864 A/C cg09473613 chr1:24152604 HMGCL 0.34 5.76 0.3 1.92e-8 Immature fraction of reticulocytes; CRC cis rs7666738 0.830 rs4492007 chr4:98959848 A/T cg05340658 chr4:99064831 C4orf37 0.61 9.54 0.47 3.45e-19 Colonoscopy-negative controls vs population controls; CRC cis rs208515 0.592 rs10944862 chr6:66674215 C/T cg07460842 chr6:66804631 NA 0.94 11.85 0.55 3.1e-27 Exhaled nitric oxide levels; CRC cis rs2067615 0.542 rs4346064 chr12:107081599 C/A cg13491945 chr12:107078410 RFX4 0.35 6.14 0.32 2.36e-9 Heart rate; CRC cis rs7937682 0.575 rs7930208 chr11:111741463 T/C cg19812747 chr11:111475976 SIK2 0.43 6.29 0.33 1.03e-9 Primary sclerosing cholangitis; CRC cis rs9649213 0.593 rs2394854 chr7:98027306 A/G cg00277769 chr7:97922759 BAIAP2L1 -0.57 -9.8 -0.48 4.49e-20 Prostate cancer (SNP x SNP interaction); CRC cis rs7945705 0.692 rs11042149 chr11:9010737 T/C cg14711859 chr11:8959438 ASCL3 0.35 6.01 0.31 4.93e-9 Hemoglobin concentration; CRC cis rs929354 1.000 rs1182391 chr7:157038368 T/C cg05182265 chr7:156933206 UBE3C 0.68 12.23 0.56 1.36e-28 Body mass index; CRC cis rs11098499 0.909 rs28793658 chr4:120307214 A/C cg24375607 chr4:120327624 NA 0.51 7.88 0.4 4.76e-14 Corneal astigmatism; CRC cis rs7914558 1.000 rs11191542 chr10:104824324 T/A cg15744005 chr10:104629667 AS3MT -0.33 -6.98 -0.36 1.64e-11 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs9914988 0.887 rs11650282 chr17:27090741 C/G cg02049041 chr17:27085579 C17orf63 0.44 5.61 0.3 4.31e-8 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs6988636 1.000 rs16898088 chr8:124190501 G/A cg27053337 chr8:124217698 FAM83A 0.43 6.59 0.34 1.74e-10 Urinary uromodulin levels; CRC cis rs9486715 0.867 rs9384602 chr6:96919561 G/A cg06623918 chr6:96969491 KIAA0776 1.01 19.93 0.74 1.64e-58 Headache; CRC trans rs1814175 0.702 rs4881644 chr11:49786367 C/T cg21153622 chr11:89784906 NA -0.37 -5.99 -0.31 5.42e-9 Height; CRC cis rs7927592 0.626 rs11228279 chr11:68309680 C/T cg01657329 chr11:68192670 LRP5 0.55 9.13 0.45 7.21e-18 Total body bone mineral density; CRC cis rs17767392 1.000 rs61991250 chr14:71869684 G/C cg13720639 chr14:72061746 SIPA1L1 -0.55 -6.95 -0.36 1.96e-11 Mitral valve prolapse; CRC cis rs972578 0.967 rs8138930 chr22:43336728 C/T cg01576275 chr22:43409880 NA -0.46 -7.47 -0.38 7.46e-13 Mean platelet volume; CRC cis rs9611565 0.512 rs139560 chr22:42194962 A/G cg06481639 chr22:41940642 POLR3H -0.59 -6.59 -0.34 1.73e-10 Vitiligo; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg22335246 chr12:120763591 PLA2G1B 0.48 7.22 0.37 3.62e-12 Response to antipsychotic treatment; CRC cis rs9900062 0.586 rs2676307 chr17:62690713 C/G cg02598441 chr17:62777298 LOC146880 -0.53 -6.82 -0.35 4.45e-11 QT interval; CRC cis rs863345 0.604 rs10908660 chr1:158466189 G/A cg12129480 chr1:158549410 OR10X1 -0.3 -6.35 -0.33 7.19e-10 Pneumococcal bacteremia; CRC cis rs2576037 0.583 rs11660085 chr18:44529603 A/G cg07643061 chr18:44555308 TCEB3C;TCEB3CL;KATNAL2 0.35 5.84 0.31 1.22e-8 Personality dimensions; CRC cis rs2019137 0.936 rs3828188 chr2:113954247 G/A cg11763394 chr2:113992921 PAX8;LOC440839;LOC654433 -0.49 -7.08 -0.36 9.03e-12 Lymphocyte counts; CRC cis rs863345 0.564 rs7540999 chr1:158504570 G/A cg12129480 chr1:158549410 OR10X1 -0.3 -6.27 -0.33 1.12e-9 Pneumococcal bacteremia; CRC cis rs2455601 1.000 rs56336128 chr11:8908299 G/A cg09997546 chr11:8931473 C11orf17;ST5 -0.51 -6.13 -0.32 2.45e-9 Schizophrenia; CRC cis rs11971779 0.616 rs6974907 chr7:139068729 G/C cg07862535 chr7:139043722 LUC7L2 0.57 7.35 0.38 1.61e-12 Diisocyanate-induced asthma; CRC cis rs9303280 0.806 rs10852935 chr17:38031674 C/T cg11212589 chr17:38028394 ZPBP2 0.42 7.79 0.39 8.57e-14 Self-reported allergy; CRC cis rs11864453 0.826 rs12325142 chr16:72138112 G/T cg23815491 chr16:72088622 HP 0.53 8.11 0.41 1.04e-14 Fibrinogen levels; CRC cis rs7827545 1.000 rs6578232 chr8:135565690 G/A cg13086574 chr8:135490821 ZFAT -0.36 -6.08 -0.32 3.34e-9 Hypertension (SNP x SNP interaction); CRC cis rs9393692 1.000 rs9393692 chr6:26276650 A/G cg00631329 chr6:26305371 NA -0.69 -12.72 -0.57 2.07e-30 Educational attainment; CRC cis rs875971 0.862 rs10950043 chr7:65988610 T/C cg12463550 chr7:65579703 CRCP 0.47 6.45 0.33 4.03e-10 Aortic root size; CRC cis rs10504229 0.683 rs56204590 chr8:58131642 T/G cg02290350 chr8:58132656 NA -0.58 -8.16 -0.41 7.29e-15 Developmental language disorder (linguistic errors); CRC cis rs2976388 0.609 rs2585144 chr8:143800269 A/T cg24046110 chr8:143859143 LYNX1 0.48 8.34 0.42 2.11e-15 Urinary tract infection frequency; CRC cis rs6693567 0.565 rs11205371 chr1:150398510 A/G cg15654264 chr1:150340011 RPRD2 0.43 6.46 0.34 3.76e-10 Migraine; CRC cis rs1387259 0.929 rs11168460 chr12:48597365 A/G cg04545296 chr12:48745243 ZNF641 0.33 5.86 0.31 1.1e-8 Obstructive sleep apnea trait (apnea hypopnea index); CRC cis rs4853012 0.838 rs4452177 chr2:74345206 A/G cg20891558 chr2:74357851 NA 0.6 9.54 0.47 3.41e-19 Gestational age at birth (maternal effect); CRC cis rs3858526 0.584 rs10769271 chr11:5860572 T/C cg02574844 chr11:5959923 NA -0.49 -6.97 -0.36 1.7e-11 DNA methylation (variation); CRC cis rs9487051 0.714 rs7744284 chr6:109616218 C/T cg12927641 chr6:109611667 NA -0.38 -6.66 -0.34 1.18e-10 Reticulocyte fraction of red cells; CRC cis rs4148883 0.737 rs13148577 chr4:100060836 G/A cg13256891 chr4:100009986 ADH5 0.46 6.7 0.35 9.16e-11 Alcohol dependence; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg08677755 chr19:7604888 PNPLA6 -0.45 -6.96 -0.36 1.81e-11 Liver disease severity in Alagille syndrome; CRC cis rs3806843 1.000 rs3806845 chr5:140180737 C/T cg19875535 chr5:140030758 IK 0.62 10.16 0.49 2.9e-21 Depressive symptoms (multi-trait analysis); CRC cis rs3858526 0.959 rs10838797 chr11:5920977 A/G cg02574844 chr11:5959923 NA -0.45 -6.32 -0.33 8.47e-10 DNA methylation (variation); CRC cis rs9361491 0.657 rs9341742 chr6:79440229 C/T cg05283184 chr6:79620031 NA -0.37 -5.69 -0.3 2.84e-8 Intelligence (multi-trait analysis); CRC cis rs2882667 0.690 rs185956 chr5:138230263 A/G cg09476006 chr5:138032270 NA 0.55 9.14 0.45 6.76e-18 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs9467711 0.606 rs12174639 chr6:26373121 G/A cg14345882 chr6:26364793 BTN3A2 0.65 5.74 0.3 2.14e-8 Autism spectrum disorder or schizophrenia; CRC cis rs2742540 0.503 rs2653556 chr11:8906636 C/G cg00186954 chr11:8933980 ST5;C11orf17 -0.64 -11.56 -0.54 3.64e-26 Hematocrit; CRC cis rs5750830 0.621 rs743838 chr22:39824707 T/G cg25956985 chr22:39795188 MAP3K7IP1 -0.46 -6.28 -0.33 1.05e-9 Intelligence (multi-trait analysis); CRC cis rs9891119 0.965 rs3816769 chr17:40498273 C/T cg06270615 chr17:40516068 STAT3 0.28 6.04 0.32 4.24e-9 Multiple sclerosis;Crohn's disease; CRC cis rs6921919 0.697 rs12180820 chr6:28316478 A/G cg03623178 chr6:28175578 NA -0.43 -5.86 -0.31 1.14e-8 Autism spectrum disorder or schizophrenia; CRC cis rs6599388 0.803 rs11248057 chr4:906131 C/G cg20814179 chr4:940893 TMEM175 -0.42 -6.88 -0.35 3.05e-11 Parkinson's disease; CRC cis rs6762477 0.748 rs9831967 chr3:50217234 C/T cg24110177 chr3:50126178 RBM5 0.46 6.98 0.36 1.63e-11 Menarche (age at onset); CRC trans rs1005277 0.540 rs116205409 chr10:38478970 G/A cg11292332 chr7:45801988 SEPT13 -0.38 -6.83 -0.35 4.14e-11 Extrinsic epigenetic age acceleration; CRC cis rs748404 0.631 rs2467745 chr15:43722742 A/G cg02155558 chr15:43621948 ADAL;LCMT2 0.53 7.88 0.4 4.67e-14 Lung cancer; CRC trans rs4332037 0.538 rs6951956 chr7:1934131 C/T cg11693508 chr17:37793320 STARD3 0.53 6.81 0.35 4.74e-11 Bipolar disorder; CRC cis rs1707322 1.000 rs10890353 chr1:46298383 G/T cg06784218 chr1:46089804 CCDC17 0.52 9.15 0.45 5.92e-18 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs208520 0.507 rs9453585 chr6:66796668 C/T cg07460842 chr6:66804631 NA -1.15 -24.54 -0.8 2.57e-76 Exhaled nitric oxide output; CRC cis rs812925 0.859 rs778138 chr2:61687214 A/C cg10580144 chr2:61372316 C2orf74 0.3 6.07 0.32 3.49e-9 Immature fraction of reticulocytes; CRC trans rs10983614 1.000 rs7867776 chr9:120072627 A/G cg08275802 chr7:155137875 NA 0.45 6.06 0.32 3.78e-9 Survival in pancreatic cancer; CRC cis rs7259376 0.902 rs10408428 chr19:22578023 G/T cg02657401 chr19:22469223 NA 0.31 6.79 0.35 5.21e-11 Menopause (age at onset); CRC cis rs561341 0.714 rs55925849 chr17:30253085 C/T cg00745463 chr17:30367425 LRRC37B -0.88 -9.65 -0.47 1.4e-19 Hip circumference adjusted for BMI; CRC cis rs9325144 0.647 rs1386018 chr12:39104360 C/T cg26384229 chr12:38710491 ALG10B -0.52 -7.34 -0.37 1.74e-12 Morning vs. evening chronotype; CRC trans rs561341 0.714 rs547473 chr17:30297560 T/G cg20587970 chr11:113659929 NA -1.18 -17.22 -0.69 7.98e-48 Hip circumference adjusted for BMI; CRC cis rs9479482 1.000 rs11155696 chr6:150357283 G/A cg25797454 chr6:150327115 RAET1K 0.38 6.51 0.34 2.8e-10 Alopecia areata; CRC cis rs9837602 0.507 rs793453 chr3:99529095 A/C cg07805332 chr3:99536008 MIR548G;C3orf26 0.54 8.27 0.41 3.46e-15 Breast cancer; CRC cis rs17227506 0.704 rs6530649 chr8:13448112 A/G cg03566418 chr8:13424080 C8orf48 -0.34 -5.86 -0.31 1.14e-8 Nonsyndromic cleft lip with cleft palate; CRC cis rs7605827 0.930 rs11679632 chr2:15605659 G/A cg19274914 chr2:15703543 NA 0.39 5.9 0.31 8.83e-9 Educational attainment (years of education); CRC cis rs477895 0.629 rs7130030 chr11:63933733 T/G cg18225595 chr11:63971243 STIP1 0.59 7.82 0.4 7.02e-14 Mean platelet volume; CRC cis rs4929949 0.809 rs1900273 chr11:8483335 G/A cg20771178 chr11:8615675 STK33 -0.34 -5.67 -0.3 3.07e-8 Body mass index; CRC cis rs6951245 1.000 rs79683221 chr7:1096139 A/G cg24642844 chr7:1081250 C7orf50 -0.78 -9.44 -0.46 7.23e-19 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC trans rs9329221 0.683 rs814359 chr8:9883132 T/G cg16141378 chr3:129829833 LOC729375 0.42 6.21 0.32 1.62e-9 Neuroticism; CRC cis rs7223966 1.000 rs6504168 chr17:61697469 G/T cg05941027 chr17:61774174 LIMD2 0.37 6.56 0.34 2.06e-10 Hip circumference adjusted for BMI;Body mass index; CRC cis rs7493 0.755 rs34774523 chr7:94962142 G/A cg21856205 chr7:94953877 PON1 -0.46 -6.11 -0.32 2.75e-9 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs9322193 0.926 rs2342860 chr6:150098777 T/C cg00933542 chr6:150070202 PCMT1 0.28 5.63 0.3 3.86e-8 Lung cancer; CRC trans rs7944735 0.507 rs7114598 chr11:48101766 C/T cg03929089 chr4:120376271 NA 0.58 7.49 0.38 6.27e-13 Intraocular pressure; CRC trans rs4785204 1.000 rs9932240 chr16:50094227 T/C cg07960154 chr17:37760198 NEUROD2 -0.66 -6.13 -0.32 2.52e-9 Esophageal cancer (squamous cell); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg26657230 chr5:94891026 TTC37;ARSK 0.39 6.18 0.32 1.87e-9 Liver disease severity in Alagille syndrome; CRC trans rs7618501 1.000 rs1049256 chr3:49763338 T/C cg21659725 chr3:3221576 CRBN -0.9 -17.34 -0.69 2.66e-48 Intelligence (multi-trait analysis); CRC cis rs7412746 0.658 rs2272214 chr1:150931462 C/T cg15448220 chr1:150897856 SETDB1 0.56 8.27 0.41 3.41e-15 Melanoma; CRC cis rs208520 0.690 rs207107 chr6:66794385 T/C cg07460842 chr6:66804631 NA -1.09 -15.38 -0.65 1.37e-40 Exhaled nitric oxide output; CRC cis rs6502050 0.835 rs8073645 chr17:80110957 C/T cg02741985 chr17:80059408 CCDC57 0.43 7.15 0.37 5.66e-12 Life satisfaction; CRC cis rs72717009 0.825 rs7529425 chr1:161479599 G/A cg23840854 chr1:161414152 NA -0.66 -7.95 -0.4 3.11e-14 Rheumatoid arthritis; CRC trans rs10504229 1.000 rs57261109 chr8:58172152 C/T cg04077850 chr5:125800366 GRAMD3 0.37 6.27 0.33 1.15e-9 Developmental language disorder (linguistic errors); CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg09920427 chr19:12777674 MORG1;MAN2B1 0.53 6.94 0.36 2.07e-11 Thyroid stimulating hormone; CRC cis rs968567 1.000 rs968567 chr11:61595564 C/T cg00603274 chr11:61596626 FADS2 -0.8 -9.26 -0.45 2.76e-18 Blood metabolite levels;Rheumatoid arthritis;Vitiligo;Glycerophospholipid levels; CRC trans rs11148252 0.840 rs3886077 chr13:52949053 C/A cg18335740 chr13:41363409 SLC25A15 0.53 8.27 0.41 3.33e-15 Lewy body disease; CRC cis rs1559088 0.948 rs12608825 chr19:33581219 C/T cg27124370 chr19:33622961 WDR88 -0.43 -5.9 -0.31 9.27e-9 Bone ultrasound measurement (broadband ultrasound attenuation); CRC cis rs9549328 0.670 rs2873372 chr13:113613383 A/G cg17524180 chr13:113633600 MCF2L -0.56 -10.22 -0.49 1.72e-21 Systolic blood pressure; CRC cis rs12541635 0.966 rs11786829 chr8:107023752 C/G cg10147462 chr8:107024639 NA 0.46 7.78 0.39 9.16e-14 Age of smoking initiation; CRC cis rs1005277 0.505 rs7917943 chr10:38195811 T/A cg00409905 chr10:38381863 ZNF37A 0.63 10.29 0.49 1.04e-21 Extrinsic epigenetic age acceleration; CRC cis rs208520 0.690 rs864314 chr6:66814830 G/A cg07460842 chr6:66804631 NA -1.2 -25.61 -0.82 2.42e-80 Exhaled nitric oxide output; CRC cis rs9462846 1.000 rs9471942 chr6:42861532 C/T cg21280719 chr6:42927975 GNMT -0.33 -5.86 -0.31 1.11e-8 Blood protein levels; CRC cis rs9372498 0.536 rs62422189 chr6:118907053 C/T cg22561889 chr6:118971681 C6orf204 0.48 5.92 0.31 8.1e-9 Diastolic blood pressure; CRC cis rs2777491 1.000 rs316609 chr15:41743828 T/A cg18705301 chr15:41695430 NDUFAF1 -0.74 -12.73 -0.57 1.87e-30 Ulcerative colitis; CRC cis rs1448094 0.511 rs61930582 chr12:86157387 T/C cg00310523 chr12:86230176 RASSF9 0.41 6.62 0.34 1.5e-10 Major depressive disorder; CRC cis rs651907 0.557 rs12629954 chr3:101360623 C/A cg12386194 chr3:101231763 SENP7 0.48 6.75 0.35 6.6e-11 Colorectal cancer; CRC cis rs10504229 0.775 rs56155911 chr8:58163247 C/T cg24829409 chr8:58192753 C8orf71 -0.61 -8.09 -0.41 1.13e-14 Developmental language disorder (linguistic errors); CRC cis rs597539 0.654 rs619727 chr11:68627535 A/G cg06028808 chr11:68637592 NA 0.42 6.81 0.35 4.66e-11 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs72945132 0.882 rs72947012 chr11:70149472 G/A cg14191688 chr11:70257035 CTTN 0.47 6.03 0.32 4.39e-9 Coronary artery disease; CRC trans rs116095464 0.558 rs10079760 chr5:230778 A/G cg00938859 chr5:1591904 SDHAP3 0.66 7.46 0.38 7.83e-13 Breast cancer; CRC cis rs11209185 0.509 rs9436357 chr1:68452488 C/T cg22082780 chr1:68452167 NA 0.49 7.78 0.39 9.2e-14 Itch intensity from mosquito bite adjusted by bite size; CRC cis rs7552404 0.727 rs5745427 chr1:76332637 C/A cg05598546 chr1:76251766 SNORD45C;RABGGTB -0.52 -5.93 -0.31 7.72e-9 Blood metabolite levels;Acylcarnitine levels; CRC trans rs747782 0.527 rs75915859 chr11:48232931 C/T cg03929089 chr4:120376271 NA 0.69 6.76 0.35 6.37e-11 Intraocular pressure; CRC cis rs2880765 0.835 rs7169632 chr15:86044667 T/G cg17133734 chr15:86042851 AKAP13 0.42 6.68 0.35 1.05e-10 Coronary artery disease; CRC cis rs6951245 1.000 rs74785791 chr7:1088494 T/C cg22907277 chr7:1156413 C7orf50 0.71 7.23 0.37 3.34e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC trans rs12744310 0.830 rs12045184 chr1:41799611 G/A cg19175123 chr10:103411746 FBXW4 0.47 6.23 0.32 1.45e-9 Cognitive ability (multi-trait analysis);Intelligence;Cognitive ability; CRC cis rs5758511 0.731 rs58302269 chr22:42351309 G/A cg00645731 chr22:42541494 CYP2D7P1 0.47 6.97 0.36 1.71e-11 Birth weight; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg04579211 chr15:41221939 DLL4 0.46 6.06 0.32 3.71e-9 Thyroid stimulating hormone; CRC cis rs9914988 0.943 rs67327562 chr17:27108828 G/A cg16670446 chr17:27188758 MIR451;MIR144 0.55 8.56 0.43 4.49e-16 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs2462686 1.000 rs1525828 chr7:46002078 T/A cg15898840 chr7:45960834 IGFBP3 -0.39 -5.86 -0.31 1.11e-8 Major depressive disorder; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg25883402 chr1:173837173 SNORD76;SNORD74;SNORD75;GAS5;ZBTB37 0.47 6.69 0.35 9.7e-11 Response to antipsychotic treatment; CRC cis rs28386778 0.897 rs4968663 chr17:61835603 A/T cg11494091 chr17:61959527 GH2 0.6 10.28 0.49 1.13e-21 Prudent dietary pattern; CRC cis rs6088580 0.524 rs6088560 chr20:33228549 T/C cg08999081 chr20:33150536 PIGU -0.37 -5.61 -0.3 4.22e-8 Glomerular filtration rate (creatinine); CRC cis rs6011002 0.745 rs6011068 chr20:62364885 T/A cg01176363 chr20:62369445 LIME1 -0.72 -5.67 -0.3 3.14e-8 Dental caries; CRC cis rs4713118 0.513 rs156739 chr6:28013410 C/A cg23161317 chr6:28129485 ZNF389 0.44 6.35 0.33 7.18e-10 Parkinson's disease; CRC cis rs61656020 1 rs61656020 chr16:1882221 C/G cg09830162 chr16:1889614 FAHD1;C16orf73 -0.84 -11.08 -0.52 1.83e-24 Ankle injury; CRC cis rs6121246 0.697 rs6120970 chr20:30232452 C/T cg18721089 chr20:30220636 NA -0.42 -6.79 -0.35 5.27e-11 Mean corpuscular hemoglobin; CRC cis rs9326248 0.813 rs7115562 chr11:117020470 A/G cg26566898 chr11:117069891 TAGLN 0.39 6.89 0.36 2.85e-11 Blood protein levels; CRC cis rs9314323 0.524 rs7816609 chr8:26202482 A/C cg13160058 chr8:26243215 BNIP3L -0.48 -7.56 -0.38 4.13e-13 Red cell distribution width; CRC cis rs7647973 0.925 rs6808036 chr3:49236439 T/G cg07690219 chr3:49449608 TCTA;RHOA -0.51 -5.96 -0.31 6.32e-9 Menarche (age at onset); CRC cis rs1707322 0.721 rs28442079 chr1:46172001 A/G cg03146154 chr1:46216737 IPP 0.67 9.82 0.48 3.95e-20 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs4654899 1.000 rs3767248 chr1:21276854 A/G cg02927042 chr1:21476669 EIF4G3 -0.48 -7.77 -0.39 1e-13 Superior frontal gyrus grey matter volume; CRC cis rs7113874 0.524 rs10840092 chr11:8624915 A/G cg17679104 chr11:8615758 STK33 0.33 5.65 0.3 3.44e-8 Body mass index in physically active individuals;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs8114671 0.562 rs7263157 chr20:33459127 G/A cg07148914 chr20:33460835 GGT7 0.41 6.71 0.35 8.73e-11 Height; CRC cis rs4285028 0.747 rs9808981 chr3:121429561 G/A cg20356878 chr3:121714668 ILDR1 -0.42 -6.01 -0.31 5.02e-9 Multiple sclerosis; CRC cis rs875971 0.767 rs1695815 chr7:65831344 A/G cg11764359 chr7:65958608 NA 0.61 9.95 0.48 1.41e-20 Aortic root size; CRC cis rs12477438 0.765 rs1453564 chr2:99564428 C/T cg14399236 chr2:99771627 LIPT1;TSGA10 -0.61 -8.33 -0.42 2.26e-15 Chronic sinus infection; CRC cis rs365302 1.000 rs294920 chr6:159622802 C/T cg14500486 chr6:159655392 FNDC1 0.46 7.14 0.37 5.84e-12 Coronary heart disease; CRC cis rs4332037 0.510 rs11762803 chr7:1886805 A/G cg25834613 chr7:1915315 MAD1L1 -0.37 -6.37 -0.33 6.19e-10 Bipolar disorder; CRC cis rs11212617 0.875 rs10789659 chr11:108255828 C/T cg14761454 chr11:108092087 ATM;NPAT 0.41 6.01 0.31 4.91e-9 Response to metformin in type 2 diabetes (glycemic); CRC cis rs7949030 0.591 rs35156678 chr11:62369881 G/A cg13298116 chr11:62369859 EML3;MTA2 0.61 10.71 0.51 3.81e-23 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; CRC cis rs4728142 0.625 rs4731533 chr7:128602142 A/G cg06630958 chr7:128577819 IRF5 -0.34 -5.63 -0.3 3.93e-8 Inflammatory bowel disease;Systemic lupus erythematosus;Ulcerative colitis; CRC cis rs10504229 0.683 rs7463453 chr8:58112053 A/G cg24829409 chr8:58192753 C8orf71 -0.55 -7.9 -0.4 4.11e-14 Developmental language disorder (linguistic errors); CRC cis rs6500602 0.963 rs7201012 chr16:4480682 C/G cg08645402 chr16:4508243 NA 0.58 9.17 0.45 5.36e-18 Schizophrenia; CRC cis rs1403694 0.695 rs5029970 chr3:186434491 T/C cg04611788 chr3:186434169 KNG1 -0.61 -9.13 -0.45 7.33e-18 Blood protein levels; CRC cis rs9443645 0.527 rs12194642 chr6:79538791 G/A cg09184832 chr6:79620586 NA -0.44 -7.58 -0.39 3.52e-13 Intelligence (multi-trait analysis); CRC cis rs3096299 0.685 rs4785571 chr16:89565169 A/G cg01788221 chr16:89496183 ANKRD11 -0.38 -5.67 -0.3 3.06e-8 Multiple myeloma (IgH translocation); CRC cis rs2836950 0.565 rs4816617 chr21:40540690 T/C cg11890956 chr21:40555474 PSMG1 -0.65 -9.86 -0.48 2.93e-20 Menarche (age at onset); CRC cis rs6502050 0.777 rs7406162 chr17:80086386 C/T cg02741985 chr17:80059408 CCDC57 -0.44 -7.15 -0.37 5.59e-12 Life satisfaction; CRC cis rs72781680 0.898 rs56216411 chr2:23934533 G/A cg08917208 chr2:24149416 ATAD2B 0.97 8.98 0.44 2.1e-17 Lymphocyte counts; CRC cis rs9549260 0.564 rs9577110 chr13:41271878 T/G cg21288729 chr13:41239152 FOXO1 0.44 6.87 0.35 3.17e-11 Red blood cell count; CRC cis rs9311474 0.508 rs2878628 chr3:52584715 C/T cg18404041 chr3:52824283 ITIH1 0.41 8.56 0.43 4.3e-16 Electroencephalogram traits; CRC cis rs9341808 0.718 rs3828754 chr6:80900640 C/G cg08355045 chr6:80787529 NA 0.43 6.94 0.36 2.08e-11 Sitting height ratio; CRC cis rs5750830 0.649 rs5757663 chr22:39821319 T/C cg25956985 chr22:39795188 MAP3K7IP1 -0.47 -6.58 -0.34 1.86e-10 Intelligence (multi-trait analysis); CRC cis rs832540 0.866 rs832579 chr5:56164943 A/G cg24531977 chr5:56204891 C5orf35 -0.45 -6.7 -0.35 9.2e-11 Coronary artery disease; CRC cis rs7412746 0.524 rs58304714 chr1:150831561 T/A cg17724175 chr1:150552817 MCL1 0.49 7.28 0.37 2.54e-12 Melanoma; CRC cis rs7264396 0.747 rs6058291 chr20:34247769 G/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.61 -10.31 -0.49 8.99e-22 Total cholesterol levels; CRC cis rs9902453 0.817 rs1038089 chr17:28178724 A/T cg26525008 chr17:28256777 EFCAB5;SSH2 0.57 8.66 0.43 2.22e-16 Coffee consumption (cups per day); CRC cis rs10504229 0.683 rs72650839 chr8:58130029 C/T cg04204079 chr8:58130323 NA -0.45 -5.78 -0.3 1.71e-8 Developmental language disorder (linguistic errors); CRC cis rs2204008 0.665 rs11495668 chr12:38221018 C/T cg26384229 chr12:38710491 ALG10B 0.68 9.03 0.45 1.49e-17 Bladder cancer; CRC cis rs9303280 0.743 rs12946510 chr17:37912377 C/T cg00129232 chr17:37814104 STARD3 -0.48 -7.49 -0.38 6.37e-13 Self-reported allergy; CRC cis rs10888329 0.744 rs6587431 chr1:248354978 T/C cg00666640 chr1:248458726 OR2T12 0.43 7.05 0.36 1.05e-11 Autism spectrum disorder; CRC trans rs1005277 0.541 rs2505193 chr10:38394638 G/C cg23533926 chr12:111358616 MYL2 -0.52 -7.82 -0.4 7.43e-14 Extrinsic epigenetic age acceleration; CRC cis rs524023 1.000 rs3825018 chr11:64358809 G/A cg14139581 chr11:64358342 SLC22A12 -0.39 -6.19 -0.32 1.81e-9 Urate levels in obese individuals; CRC cis rs7618915 0.571 rs11130307 chr3:52607682 G/A cg18099408 chr3:52552593 STAB1 -0.45 -7.39 -0.38 1.23e-12 Bipolar disorder; CRC cis rs9733 0.525 rs11584184 chr1:150695689 A/T cg17724175 chr1:150552817 MCL1 0.57 9.12 0.45 7.76e-18 Tonsillectomy; CRC cis rs10791323 0.575 rs4489760 chr11:133732265 A/T cg15485101 chr11:133734466 NA 0.46 8.4 0.42 1.36e-15 Childhood ear infection; CRC cis rs9467711 0.606 rs28362606 chr6:26365586 T/C cg14345882 chr6:26364793 BTN3A2 0.66 5.77 0.3 1.8e-8 Autism spectrum disorder or schizophrenia; CRC cis rs9325144 0.600 rs7312522 chr12:38730423 A/G cg26384229 chr12:38710491 ALG10B 0.54 8.06 0.41 1.45e-14 Morning vs. evening chronotype; CRC cis rs10782582 0.593 rs4646960 chr1:76211103 C/A cg10523679 chr1:76189770 ACADM -0.43 -6.08 -0.32 3.39e-9 Daytime sleep phenotypes; CRC cis rs9322193 0.923 rs35967444 chr6:149996724 G/A cg13206674 chr6:150067644 NUP43 0.64 9.6 0.47 2.18e-19 Lung cancer; CRC cis rs2404602 0.647 rs11629727 chr15:77009038 G/C cg03037974 chr15:76606532 NA -0.48 -6.89 -0.36 2.8e-11 Blood metabolite levels; CRC cis rs17711722 0.701 rs781145 chr7:65440370 A/C cg05627663 chr7:65219948 SNORA22;CCT6P1 0.48 7.18 0.37 4.65e-12 Calcium levels; CRC cis rs561341 1.000 rs117979353 chr17:30272866 A/G cg19193384 chr17:30244184 NA -0.65 -7.5 -0.38 6.06e-13 Hip circumference adjusted for BMI; CRC cis rs73206853 0.563 rs7960761 chr12:111164415 T/C cg12870014 chr12:110450643 ANKRD13A 0.76 7.9 0.4 4.34e-14 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC cis rs7567389 0.600 rs72845979 chr2:128095754 C/A cg09760422 chr2:128146352 NA 0.34 5.61 0.3 4.2e-8 Self-rated health; CRC trans rs2303319 0.504 rs62189047 chr2:162613314 T/A cg13490827 chr1:46269305 MAST2 -0.69 -6.0 -0.31 5.24e-9 Cognitive function; CRC trans rs6788895 0.661 rs1533711 chr3:150469996 C/T cg02509730 chr13:100310205 CLYBL 0.6 6.07 0.32 3.46e-9 Breast cancer; CRC cis rs1347297 0.666 rs4019558 chr2:179270883 A/T cg03991736 chr2:179345203 MIR548N;PLEKHA3 -0.41 -5.81 -0.31 1.44e-8 Alzheimer disease and age of onset; CRC cis rs875971 0.660 rs801190 chr7:66033033 C/T cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.43 -6.31 -0.33 9.14e-10 Aortic root size; CRC cis rs7666738 0.791 rs11730069 chr4:98945772 A/G cg17366294 chr4:99064904 C4orf37 0.43 7.34 0.38 1.69e-12 Colonoscopy-negative controls vs population controls; CRC trans rs1814175 0.817 rs7932683 chr11:49983640 G/A cg15704280 chr7:45808275 SEPT13 -1.02 -20.61 -0.75 3.5e-61 Height; CRC trans rs8002861 0.665 rs2065926 chr13:44422371 A/G cg12856521 chr11:46389249 DGKZ -0.49 -8.23 -0.41 4.46e-15 Leprosy; CRC cis rs34172651 0.917 rs2059134 chr16:24816492 C/T cg06028605 chr16:24865363 SLC5A11 -0.44 -8.12 -0.41 9.42e-15 Intelligence (multi-trait analysis); CRC cis rs796364 1.000 rs1658807 chr2:200767512 C/T cg25936922 chr2:200820526 C2orf60;C2orf47 0.7 7.69 0.39 1.67e-13 Schizophrenia; CRC trans rs9956878 0.555 rs8085188 chr18:73544676 A/G cg11012683 chr17:4402158 SPNS2 -0.38 -6.0 -0.31 5.32e-9 Obesity-related traits; CRC cis rs2256039 1.000 rs2245879 chr9:86789653 A/C cg14555996 chr9:86785905 NA -0.39 -5.68 -0.3 2.96e-8 Multiple system atrophy; CRC trans rs2303319 0.504 rs58622044 chr2:162596287 A/G cg11326919 chr17:43324904 LOC100133991 -0.65 -6.03 -0.32 4.51e-9 Cognitive function; CRC cis rs722599 0.748 rs61978948 chr14:75363369 G/A cg08847533 chr14:75593920 NEK9 -0.43 -5.75 -0.3 2.09e-8 IgG glycosylation; CRC trans rs8002861 0.905 rs12874590 chr13:44433363 C/T cg12856521 chr11:46389249 DGKZ -0.4 -6.57 -0.34 1.94e-10 Leprosy; CRC cis rs6963495 0.546 rs2697020 chr7:105150046 C/T cg02135003 chr7:105160482 PUS7 -0.53 -8.34 -0.42 2.05e-15 Bipolar disorder (body mass index interaction); CRC cis rs16975963 0.644 rs73033139 chr19:38091685 A/C cg15135657 chr19:38346511 NA -0.46 -6.3 -0.33 9.32e-10 Longevity; CRC cis rs10464366 0.517 rs13231075 chr7:39174806 G/T cg20302533 chr7:39170763 POU6F2 0.41 5.66 0.3 3.38e-8 IgG glycosylation; CRC cis rs7727544 0.904 rs58835386 chr5:131600559 A/G cg20512303 chr5:131592959 PDLIM4 0.29 5.61 0.3 4.2e-8 Blood metabolite levels; CRC cis rs5750830 0.649 rs5757657 chr22:39798429 G/T cg25956985 chr22:39795188 MAP3K7IP1 -0.43 -6.44 -0.33 4.22e-10 Intelligence (multi-trait analysis); CRC cis rs2573652 1.000 rs2581343 chr15:100514418 C/G cg00587665 chr15:100533223 ADAMTS17 -0.4 -6.84 -0.35 3.91e-11 Height; CRC cis rs79387448 0.745 rs2310294 chr2:103165706 A/G cg00507830 chr2:103233733 NA 0.53 5.83 0.31 1.33e-8 Gut microbiota (bacterial taxa); CRC cis rs2576037 0.623 rs2571000 chr18:44580347 G/A cg20875182 chr18:44561130 TCEB3B;KATNAL2 -0.62 -9.89 -0.48 2.25e-20 Personality dimensions; CRC cis rs6460942 0.643 rs80264734 chr7:12233800 T/A cg06484146 chr7:12443880 VWDE -0.58 -6.08 -0.32 3.36e-9 Coronary artery disease; CRC cis rs7429990 0.965 rs4599334 chr3:48066400 A/C cg11946769 chr3:48343235 NME6 -0.47 -6.03 -0.32 4.4e-9 Educational attainment (years of education); CRC cis rs11168351 0.517 rs10875754 chr12:48557922 G/C cg21466736 chr12:48725269 NA -0.45 -6.98 -0.36 1.67e-11 Bipolar disorder and schizophrenia; CRC cis rs75804782 0.641 rs72987327 chr2:239359833 T/G cg18131467 chr2:239335373 ASB1 -0.72 -6.21 -0.32 1.62e-9 Morning vs. evening chronotype;Chronotype; CRC cis rs477692 0.699 rs578932 chr10:131370724 C/A cg05714579 chr10:131428358 MGMT 0.49 6.82 0.35 4.49e-11 Response to temozolomide; CRC cis rs561341 0.714 rs547473 chr17:30297560 T/G cg12193833 chr17:30244370 NA -0.62 -7.94 -0.4 3.33e-14 Hip circumference adjusted for BMI; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg04320405 chr7:131012679 MKLN1 0.5 7.06 0.36 1.01e-11 Anxiety disorder; CRC cis rs2380220 0.720 rs9398251 chr6:95984709 C/T cg04719120 chr6:96025338 MANEA 0.55 6.61 0.34 1.52e-10 Behavioural disinhibition (generation interaction); CRC cis rs1799949 0.965 rs12947782 chr17:41279882 A/G cg25072359 chr17:41440525 NA 0.46 6.93 0.36 2.19e-11 Menopause (age at onset); CRC cis rs7493 1.000 rs2068604 chr7:95041542 G/T cg19678392 chr7:94953810 PON1 -0.57 -7.07 -0.36 9.34e-12 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs2658782 0.547 rs3020052 chr11:93055184 C/G cg15737290 chr11:93063684 CCDC67 0.66 10.45 0.5 2.97e-22 Pulmonary function decline; CRC cis rs1865760 1.000 rs1865760 chr6:25916979 C/T cg17691542 chr6:26056736 HIST1H1C 0.56 8.47 0.42 8.18e-16 Height; CRC trans rs1499614 1.000 rs2141924 chr7:66186246 C/T cg10756647 chr7:56101905 PSPH 0.76 7.93 0.4 3.53e-14 Gout; CRC cis rs116095464 0.558 rs56081398 chr5:247318 C/T cg22496380 chr5:211416 CCDC127 -1.0 -10.06 -0.48 6.41e-21 Breast cancer; CRC cis rs1878931 0.624 rs27235 chr16:3439138 G/C cg02880119 chr16:3481970 NA 0.43 5.98 0.31 5.8e-9 Body mass index (adult); CRC cis rs3026101 0.671 rs57085931 chr17:5305370 T/C cg25236894 chr17:5323110 RPAIN;NUP88 0.42 6.9 0.36 2.74e-11 Body mass index; CRC cis rs801193 0.844 rs2244022 chr7:66202430 A/G cg11764359 chr7:65958608 NA 0.52 8.03 0.4 1.75e-14 Aortic root size; CRC cis rs7811142 1.000 rs7783159 chr7:100017454 C/T cg00814883 chr7:100076585 TSC22D4 -0.78 -9.6 -0.47 2.1e-19 Platelet count; CRC trans rs11098499 0.604 rs12642411 chr4:120580525 T/C cg25214090 chr10:38739885 LOC399744 0.61 9.25 0.45 2.86e-18 Corneal astigmatism; CRC cis rs6504663 1.000 rs6504661 chr17:48580126 A/T cg00901687 chr17:48585270 MYCBPAP -0.49 -7.09 -0.36 8.3e-12 Visceral fat; CRC trans rs10242455 0.571 rs117370443 chr7:98975258 T/C cg09045935 chr12:6379348 NA 0.88 6.87 0.35 3.29e-11 Blood metabolite levels; CRC trans rs16846053 0.786 rs62187647 chr2:162446018 C/T cg12500891 chr11:57225987 NA -0.67 -6.03 -0.32 4.51e-9 Blood osmolality (transformed sodium); CRC cis rs10782582 0.609 rs11161848 chr1:76367722 A/G cg03433033 chr1:76189801 ACADM -0.43 -6.14 -0.32 2.38e-9 Daytime sleep phenotypes; CRC cis rs10504229 0.683 rs113492050 chr8:58130046 A/G cg21724239 chr8:58056113 NA 0.49 6.81 0.35 4.75e-11 Developmental language disorder (linguistic errors); CRC cis rs7945705 0.967 rs7123861 chr11:8892323 G/A cg21881798 chr11:8931708 C11orf17;ST5 0.67 10.38 0.5 5.13e-22 Hemoglobin concentration; CRC trans rs867371 0.502 rs2047679 chr15:82531881 T/C cg04831495 chr15:85060580 GOLGA6L5 -0.39 -6.14 -0.32 2.34e-9 Cognitive ability;Cognitive ability (multi-trait analysis); CRC cis rs738321 0.757 rs2235345 chr22:38518177 C/T cg25457927 chr22:38595422 NA -0.33 -6.36 -0.33 6.73e-10 Breast cancer; CRC cis rs11792861 0.890 rs57387569 chr9:111920392 T/C cg05043794 chr9:111880884 C9orf5 -0.34 -6.22 -0.32 1.48e-9 Menarche (age at onset); CRC trans rs2303319 0.504 rs58622044 chr2:162596287 A/G cg22988483 chr14:93581567 ITPK1 -0.66 -6.05 -0.32 4.02e-9 Cognitive function; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg27520502 chr17:26684562 POLDIP2;TMEM199 0.41 6.32 0.33 8.52e-10 Liver disease severity in Alagille syndrome; CRC cis rs7208859 0.623 rs383436 chr17:28959179 A/G cg01831904 chr17:28903510 LRRC37B2 -0.61 -6.11 -0.32 2.86e-9 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs9322193 0.926 rs3805751 chr6:150112329 G/A cg13206674 chr6:150067644 NUP43 0.56 7.97 0.4 2.71e-14 Lung cancer; CRC cis rs7447593 0.666 rs10866705 chr5:176801131 G/T cg05207973 chr5:176823642 SLC34A1 -0.36 -5.95 -0.31 6.74e-9 Urinary electrolytes (magnesium/calcium ratio); CRC cis rs853679 0.517 rs17711801 chr6:28092307 C/G cg25164649 chr6:28176230 NA 0.76 9.53 0.46 3.71e-19 Depression; CRC cis rs4766646 0.600 rs3782893 chr12:110293678 G/C cg01252219 chr12:110302105 GLTP 0.42 6.44 0.33 4.21e-10 Metabolite levels (MHPG); CRC cis rs4713118 0.662 rs9393881 chr6:28023751 C/G cg03623178 chr6:28175578 NA 0.88 12.21 0.56 1.5e-28 Parkinson's disease; CRC trans rs3794271 0.706 rs9971816 chr12:20826911 C/T cg23196781 chr12:27117782 FGFR1OP2 0.42 6.21 0.32 1.64e-9 Response to TNF-alpha inhibitors in rheumatoid arthritis; CRC cis rs4722166 0.630 rs4722168 chr7:22779002 G/A cg26061582 chr7:22766209 IL6 0.55 8.35 0.42 1.92e-15 Lung cancer; CRC cis rs7666738 0.927 rs4699328 chr4:99055890 C/T cg17366294 chr4:99064904 C4orf37 0.39 6.67 0.35 1.06e-10 Colonoscopy-negative controls vs population controls; CRC cis rs9372498 0.572 rs62422190 chr6:118909235 A/G cg15382696 chr6:118971807 C6orf204 0.59 7.46 0.38 7.96e-13 Diastolic blood pressure; CRC cis rs6582630 0.502 rs11504451 chr12:38425294 G/A cg26384229 chr12:38710491 ALG10B 0.65 8.92 0.44 3.37e-17 Drug-induced liver injury (flucloxacillin); CRC trans rs12599106 0.754 rs11640596 chr16:34347277 T/C cg03395511 chr6:291903 DUSP22 -0.51 -6.92 -0.36 2.41e-11 Menopause (age at onset); CRC cis rs881375 0.933 rs7028641 chr9:123691141 G/C cg00246817 chr9:123691163 NA -0.43 -5.61 -0.3 4.37e-8 Rheumatoid arthritis; CRC trans rs2055729 0.677 rs592420 chr8:9760420 A/G cg06636001 chr8:8085503 FLJ10661 0.55 6.96 0.36 1.87e-11 Multiple myeloma (hyperdiploidy); CRC cis rs2976388 1.000 rs2572910 chr8:143770135 C/G cg20041105 chr8:143859282 LYNX1 -0.35 -6.05 -0.32 4.01e-9 Urinary tract infection frequency; CRC cis rs4285028 0.847 rs1986712 chr3:121710986 A/G cg20356878 chr3:121714668 ILDR1 -0.51 -7.17 -0.37 4.83e-12 Multiple sclerosis; CRC cis rs10540 1.000 rs79440439 chr11:478147 A/C cg19913688 chr11:428466 ANO9 -0.73 -6.95 -0.36 2e-11 Body mass index; CRC cis rs1941023 0.503 rs12798266 chr11:60118851 G/A cg08716584 chr11:60157161 MS4A7 -0.49 -8.21 -0.41 5.06e-15 Congenital heart disease (maternal effect); CRC cis rs2243480 1.000 rs4718269 chr7:65200778 C/G cg12463550 chr7:65579703 CRCP -0.67 -6.38 -0.33 6.06e-10 Diabetic kidney disease; CRC cis rs853679 0.517 rs9393901 chr6:28136797 A/G cg18032046 chr6:28092343 ZSCAN16 -0.51 -5.93 -0.31 7.47e-9 Depression; CRC cis rs10979 1.000 rs9376762 chr6:143887248 G/A cg25407410 chr6:143891975 LOC285740 -0.83 -13.54 -0.6 1.73e-33 Hypospadias; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg02096396 chr2:26395556 FAM59B 0.37 6.05 0.32 3.87e-9 Liver disease severity in Alagille syndrome; CRC cis rs877282 1.000 rs71494928 chr10:769134 A/G cg06581033 chr10:766294 NA -0.51 -5.78 -0.3 1.7e-8 Uric acid levels; CRC cis rs9649213 0.593 rs6465677 chr7:98003552 C/T cg00277769 chr7:97922759 BAIAP2L1 -0.6 -10.37 -0.5 5.45e-22 Prostate cancer (SNP x SNP interaction); CRC cis rs8180040 0.903 rs2276854 chr3:47276968 C/T cg10298567 chr3:47292165 KIF9 -0.41 -6.67 -0.35 1.06e-10 Colorectal cancer; CRC cis rs9309711 0.621 rs11127428 chr2:3471146 T/C cg15541040 chr2:3486749 NA -0.51 -8.15 -0.41 7.77e-15 Neurofibrillary tangles; CRC trans rs7580658 0.614 rs7585198 chr2:127962635 C/T cg09730361 chr9:20622599 MLLT3 -0.44 -5.97 -0.31 6.3e-9 Protein C levels; CRC cis rs6545883 0.811 rs778753 chr2:61780200 T/A cg15711740 chr2:61764176 XPO1 -0.41 -5.74 -0.3 2.21e-8 Tuberculosis; CRC cis rs4819052 0.851 rs13052344 chr21:46676101 C/T cg11663144 chr21:46675770 NA -0.83 -14.25 -0.62 3.35e-36 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs6570726 0.935 rs384519 chr6:145846017 C/A cg05347473 chr6:146136440 FBXO30 0.38 6.13 0.32 2.5e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs7618915 0.547 rs11130311 chr3:52675005 T/C cg18099408 chr3:52552593 STAB1 -0.43 -7.08 -0.36 8.86e-12 Bipolar disorder; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg13985271 chr9:97140681 HIATL1 -0.44 -7.3 -0.37 2.12e-12 Liver disease severity in Alagille syndrome; CRC cis rs1790761 0.559 rs10896190 chr11:67406123 T/C cg24690094 chr11:67383802 NA 0.38 6.56 0.34 2.07e-10 Mean corpuscular volume; CRC cis rs55823223 0.564 rs1463485 chr17:73851791 C/G cg14829360 chr17:73884958 NA -0.44 -7.05 -0.36 1.03e-11 Psoriasis; CRC cis rs4804416 1.000 rs4804416 chr19:7223848 G/T cg09779027 chr19:7224513 INSR -0.65 -10.97 -0.52 4.48e-24 Thyroid hormone levels;Hypothyroidism; CRC cis rs10791323 0.569 rs2282601 chr11:133712594 C/G cg06766960 chr11:133703094 NA -0.34 -5.72 -0.3 2.34e-8 Childhood ear infection; CRC cis rs1707322 0.752 rs11211145 chr1:46108491 A/C cg06784218 chr1:46089804 CCDC17 0.65 11.79 0.54 5.42e-27 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs11212617 0.840 rs172894 chr11:108262090 C/A cg12106634 chr11:108092400 ATM;NPAT 0.39 5.69 0.3 2.88e-8 Response to metformin in type 2 diabetes (glycemic); CRC trans rs9393777 0.841 rs13207082 chr6:27251379 A/G cg06606381 chr12:133084897 FBRSL1 -1.19 -8.02 -0.4 1.94e-14 Intelligence (multi-trait analysis); CRC cis rs3733585 0.673 rs7434391 chr4:9967682 C/G cg11266682 chr4:10021025 SLC2A9 -0.47 -9.55 -0.47 3.01e-19 Cleft plate (environmental tobacco smoke interaction); CRC cis rs13191362 1.000 rs13207239 chr6:163008772 A/C cg23758597 chr6:163146217 PARK2 -0.54 -6.02 -0.31 4.72e-9 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs13315871 0.790 rs28502788 chr3:58296208 A/T cg20936604 chr3:58311152 NA -0.73 -7.56 -0.38 4.03e-13 Cholesterol, total; CRC cis rs739401 0.595 rs402806 chr11:3066432 A/G cg25174290 chr11:3078921 CARS 0.49 7.35 0.38 1.56e-12 Longevity; CRC cis rs9768139 0.733 rs12698208 chr7:158117575 C/T cg23298862 chr7:158159286 PTPRN2 0.41 6.39 0.33 5.71e-10 Calcium levels; CRC cis rs6951245 0.572 rs112072378 chr7:1039400 C/T cg24642844 chr7:1081250 C7orf50 -0.93 -7.82 -0.4 7.24e-14 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs6598955 0.543 rs60676610 chr1:26543421 G/C cg04990556 chr1:26633338 UBXN11 0.84 9.89 0.48 2.27e-20 Obesity-related traits; CRC cis rs881375 0.967 rs10435844 chr9:123668199 G/T cg09586646 chr9:123605570 PSMD5;LOC253039 0.53 7.17 0.37 5.01e-12 Rheumatoid arthritis; CRC cis rs4728142 0.604 rs12155080 chr7:128658739 C/G cg06630958 chr7:128577819 IRF5 -0.36 -5.86 -0.31 1.1e-8 Inflammatory bowel disease;Systemic lupus erythematosus;Ulcerative colitis; CRC cis rs6502050 0.769 rs8068708 chr17:80120424 T/C cg02741985 chr17:80059408 CCDC57 0.43 7.16 0.37 5.47e-12 Life satisfaction; CRC cis rs2573652 1.000 rs2727196 chr15:100513529 C/T cg00587665 chr15:100533223 ADAMTS17 -0.35 -6.01 -0.31 4.93e-9 Height; CRC cis rs9811920 0.732 rs793446 chr3:99578114 A/T cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G -0.41 -5.75 -0.3 2.02e-8 Axial length; CRC cis rs870825 0.520 rs10022842 chr4:185649459 A/G cg04058563 chr4:185651563 MLF1IP 0.72 9.3 0.46 2.04e-18 Blood protein levels; CRC cis rs6433857 0.594 rs11680811 chr2:181519898 A/G cg23363182 chr2:181467187 NA -0.47 -7.31 -0.37 2.03e-12 Body mass index; CRC cis rs910316 0.699 rs175039 chr14:75468950 G/C cg08847533 chr14:75593920 NEK9 -0.85 -14.36 -0.62 1.21e-36 Height; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg12737363 chr1:183604674 ARPC5;RGL1 0.5 6.44 0.33 4.14e-10 Thyroid stimulating hormone; CRC cis rs4665809 0.887 rs2384324 chr2:26354239 A/G cg22920501 chr2:26401640 FAM59B -0.6 -7.87 -0.4 5.32e-14 Gut microbiome composition (summer); CRC cis rs9341808 0.754 rs10806185 chr6:80954511 G/A cg08355045 chr6:80787529 NA 0.42 6.81 0.35 4.67e-11 Sitting height ratio; CRC trans rs6951245 0.572 rs79396675 chr7:1055047 C/T cg13565492 chr6:43139072 SRF -0.85 -6.23 -0.32 1.42e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs1005277 0.505 rs200936 chr10:38134935 T/C cg25517755 chr10:38738941 LOC399744 -0.45 -6.62 -0.34 1.47e-10 Extrinsic epigenetic age acceleration; CRC cis rs4889855 0.614 rs7208670 chr17:78494220 T/G cg16591659 chr17:78472290 NA -0.61 -7.47 -0.38 7.19e-13 Fractional excretion of uric acid; CRC cis rs2019137 0.560 rs4849179 chr2:113985170 C/T cg09704166 chr2:114031854 PAX8;LOC440839 -0.35 -6.67 -0.35 1.08e-10 Lymphocyte counts; CRC cis rs1152591 0.543 rs1152590 chr14:64681193 C/T cg21174375 chr14:64681225 SYNE2 0.39 6.3 0.33 9.65e-10 Atrial fibrillation; CRC trans rs3733585 0.775 rs13124007 chr4:10043931 G/C cg26043149 chr18:55253948 FECH 0.51 7.63 0.39 2.62e-13 Cleft plate (environmental tobacco smoke interaction); CRC cis rs4268898 0.662 rs2891380 chr2:24525830 G/A cg06627628 chr2:24431161 ITSN2 -0.83 -11.62 -0.54 2.25e-26 Asthma; CRC cis rs6502050 0.799 rs34448080 chr17:80121275 A/G cg22110888 chr17:80059540 CCDC57 0.4 6.38 0.33 5.96e-10 Life satisfaction; CRC cis rs897984 0.542 rs11865038 chr16:31095171 C/T cg00531865 chr16:30841666 NA -0.42 -6.09 -0.32 3.15e-9 Dementia with Lewy bodies; CRC cis rs738322 0.555 rs6001029 chr22:38555193 C/A cg25457927 chr22:38595422 NA -0.36 -7.43 -0.38 9.66e-13 Cutaneous nevi; CRC cis rs2032447 0.839 rs199751 chr6:26015583 T/C cg03517284 chr6:25882590 NA -0.54 -7.39 -0.38 1.19e-12 Intelligence (multi-trait analysis); CRC cis rs2404602 0.646 rs3764245 chr15:77223176 G/C cg22467129 chr15:76604101 ETFA -0.4 -6.0 -0.31 5.13e-9 Blood metabolite levels; CRC cis rs734999 0.549 rs2764840 chr1:2529437 C/T cg18854424 chr1:2615690 NA -0.5 -9.85 -0.48 3.03e-20 Ulcerative colitis; CRC cis rs78456975 1.000 rs6744743 chr2:1558161 C/T cg01028140 chr2:1542097 TPO 0.54 5.67 0.3 3.12e-8 Placebo response in major depressive disorder (% change in symptom score); CRC cis rs10197940 0.578 rs2432957 chr2:152287897 A/C cg06191203 chr2:152266755 RIF1 -0.43 -6.1 -0.32 3.04e-9 Lung cancer; CRC cis rs763014 0.966 rs4984903 chr16:680695 A/G cg07343612 chr16:622815 PIGQ -0.79 -13.19 -0.59 3.47e-32 Height; CRC cis rs2457480 0.850 rs61855743 chr10:44681729 A/G cg09554077 chr10:44749378 NA 0.68 7.34 0.38 1.65e-12 Coronary artery disease; CRC cis rs972578 1.000 rs4822242 chr22:43375439 G/A cg01576275 chr22:43409880 NA -0.48 -7.65 -0.39 2.25e-13 Mean platelet volume; CRC cis rs9311474 0.597 rs6778735 chr3:52565100 T/C cg08222913 chr3:52553049 STAB1 -0.42 -8.62 -0.43 2.95e-16 Electroencephalogram traits; CRC cis rs12545109 0.800 rs1553969 chr8:57420187 A/G cg09654669 chr8:57350985 NA -0.45 -7.22 -0.37 3.74e-12 Obesity-related traits; CRC cis rs11098499 0.908 rs28559989 chr4:120386627 C/T cg09307838 chr4:120376055 NA 0.71 10.92 0.52 6.75e-24 Corneal astigmatism; CRC cis rs7666738 0.680 rs11097613 chr4:99079991 G/T cg17366294 chr4:99064904 C4orf37 0.39 6.45 0.34 3.91e-10 Colonoscopy-negative controls vs population controls; CRC cis rs1552244 0.816 rs56387520 chr3:10042782 C/T cg02579736 chr3:10068473 FANCD2;CIDECP 0.93 12.04 0.55 6.69e-28 Alzheimer's disease; CRC cis rs7209700 0.574 rs3851806 chr17:45350919 G/C cg18085866 chr17:45331354 ITGB3 -0.52 -6.47 -0.34 3.49e-10 IgG glycosylation; CRC cis rs951366 1.000 rs4951261 chr1:205717823 A/C cg24503407 chr1:205819492 PM20D1 -0.43 -6.09 -0.32 3.19e-9 Menarche (age at onset); CRC cis rs12760731 0.582 rs74967269 chr1:178571703 T/C cg00404053 chr1:178313656 RASAL2 0.65 7.01 0.36 1.36e-11 Obesity-related traits; CRC cis rs1218582 0.772 rs4845690 chr1:154886817 C/T cg03351412 chr1:154909251 PMVK -0.55 -8.94 -0.44 2.85e-17 Prostate cancer; CRC cis rs6089584 0.927 rs2281734 chr20:60582401 C/A cg23262073 chr20:60523788 NA -0.41 -6.84 -0.35 3.92e-11 Body mass index; CRC cis rs72772090 0.539 rs11748795 chr5:96168056 G/T cg17330273 chr5:96107758 CAST;ERAP1 -0.6 -5.88 -0.31 1.01e-8 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs10911232 0.507 rs10911234 chr1:183053001 A/C ch.1.3577855R chr1:183094577 LAMC1 0.84 14.59 0.63 1.55e-37 Hypertriglyceridemia; CRC cis rs270601 0.770 rs932019 chr5:131599370 T/C cg24060327 chr5:131705240 SLC22A5 -0.39 -6.03 -0.32 4.47e-9 Acylcarnitine levels; CRC cis rs9487051 0.734 rs56214745 chr6:109536748 G/T cg21918786 chr6:109611834 NA -0.35 -5.92 -0.31 8e-9 Reticulocyte fraction of red cells; CRC cis rs3857067 0.806 rs12513267 chr4:95109545 C/T cg11021082 chr4:95130006 SMARCAD1 -0.5 -7.8 -0.4 8.18e-14 QT interval; CRC cis rs3768617 0.510 rs2093985 chr1:183094322 C/T ch.1.3577855R chr1:183094577 LAMC1 0.9 15.97 0.66 6.5e-43 Fuchs's corneal dystrophy; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg19741500 chr1:27930843 AHDC1 0.4 5.99 0.31 5.52e-9 Intelligence (multi-trait analysis); CRC cis rs9534288 0.797 rs7982998 chr13:46601535 C/T cg15192986 chr13:46630673 CPB2 -0.67 -9.81 -0.48 4.16e-20 Blood protein levels; CRC trans rs875971 0.660 rs2191268 chr7:66110224 C/T cg26803216 chr1:193029757 TROVE2;UCHL5 -0.4 -6.43 -0.33 4.45e-10 Aortic root size; CRC cis rs6541297 0.941 rs6665258 chr1:230279058 G/A cg05784532 chr1:230284198 GALNT2 0.44 6.19 0.32 1.75e-9 Coronary artery disease; CRC cis rs311392 1.000 rs311392 chr8:55084782 A/G cg06042504 chr8:55087323 NA -0.42 -6.72 -0.35 8.23e-11 Pelvic organ prolapse (moderate/severe); CRC trans rs10242455 0.702 rs75156180 chr7:98964100 G/A cg09045935 chr12:6379348 NA 0.89 6.64 0.34 1.32e-10 Blood metabolite levels; CRC cis rs4929949 0.809 rs1900273 chr11:8483335 G/A cg02811074 chr11:8615871 STK33 -0.36 -6.15 -0.32 2.24e-9 Body mass index; CRC cis rs561341 0.941 rs2470236 chr17:30304940 G/C cg19193384 chr17:30244184 NA -0.53 -6.67 -0.35 1.06e-10 Hip circumference adjusted for BMI; CRC cis rs7493 0.901 rs17879517 chr7:95030646 T/C cg04155289 chr7:94953770 PON1 -0.58 -7.18 -0.37 4.59e-12 Yu-Zhi constitution type in type 2 diabetes; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg20713816 chr5:89705801 CETN3 0.41 6.99 0.36 1.51e-11 Liver disease severity in Alagille syndrome; CRC cis rs7605827 0.930 rs59135666 chr2:15592448 G/A cg19274914 chr2:15703543 NA 0.39 5.9 0.31 9.14e-9 Educational attainment (years of education); CRC cis rs597539 0.652 rs654071 chr11:68653432 A/C cg06112835 chr11:68658793 MRPL21 0.47 7.57 0.38 3.88e-13 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs2859741 0.967 rs522481 chr1:37488337 C/T cg09363841 chr1:37513479 NA -0.62 -11.56 -0.54 3.75e-26 Forced expiratory volume in 1 second (environmental tobacco smoke interaction); CRC trans rs1814175 0.817 rs10839318 chr11:49657511 G/C cg03929089 chr4:120376271 NA -0.94 -17.71 -0.7 8.92e-50 Height; CRC cis rs1035144 0.524 rs8009260 chr14:81408591 G/T cg06600135 chr14:81408086 NA 0.56 8.79 0.44 8.47e-17 Male sexual orientation; CRC cis rs3733346 0.553 rs6813110 chr4:942660 C/T cg04824913 chr4:887549 GAK 0.42 6.03 0.32 4.37e-9 Sjögren's syndrome; CRC cis rs1862618 0.853 rs10461617 chr5:56104308 A/G cg18230493 chr5:56204884 C5orf35 -0.73 -9.38 -0.46 1.15e-18 Initial pursuit acceleration; CRC cis rs7927592 0.717 rs7126451 chr11:68257386 A/G cg01657329 chr11:68192670 LRP5 0.5 8.18 0.41 6.38e-15 Total body bone mineral density; CRC cis rs614226 0.938 rs7963543 chr12:120923948 C/A cg27489772 chr12:121021490 NA 0.48 6.81 0.35 4.64e-11 Type 1 diabetes nephropathy; CRC cis rs904251 0.647 rs2776908 chr6:37434857 T/C cg01843034 chr6:37503916 NA -0.4 -5.84 -0.31 1.27e-8 Cognitive performance; CRC cis rs7091068 0.566 rs7909925 chr10:95507170 A/G cg20715218 chr10:95462985 C10orf4 0.53 5.65 0.3 3.53e-8 Urinary tract infection frequency; CRC cis rs6424115 1.000 rs34477640 chr1:24154067 T/C cg24699146 chr1:24152579 HMGCL -0.32 -5.69 -0.3 2.83e-8 Immature fraction of reticulocytes; CRC cis rs1971762 0.521 rs5009146 chr12:54089297 A/C cg06632207 chr12:54070931 ATP5G2 0.42 7.08 0.36 8.82e-12 Height; CRC cis rs73206853 0.841 rs28480627 chr12:110834659 T/C cg12870014 chr12:110450643 ANKRD13A 0.85 10.16 0.49 2.87e-21 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC trans rs6500957 0.920 rs17648524 chr16:7459683 C/G cg14178696 chr11:47291038 MADD 0.42 6.15 0.32 2.31e-9 Spherical equivalent (joint analysis main effects and education interaction); CRC cis rs2404602 0.692 rs55676827 chr15:76961716 C/T cg23625390 chr15:77176239 SCAPER 0.49 7.22 0.37 3.68e-12 Blood metabolite levels; CRC cis rs1448094 0.511 rs17345975 chr12:86202318 T/A cg25456477 chr12:86230367 RASSF9 0.35 6.13 0.32 2.47e-9 Major depressive disorder; CRC cis rs875971 0.862 rs778686 chr7:65835910 C/T cg00343986 chr7:65444356 GUSB 0.4 5.62 0.3 4.16e-8 Aortic root size; CRC cis rs6951245 0.744 rs10265758 chr7:1172518 C/T cg18402987 chr7:1209562 NA 0.65 7.59 0.39 3.23e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg12582905 chr11:310771 NA 0.4 6.41 0.33 5.19e-10 Liver disease severity in Alagille syndrome; CRC cis rs2842992 0.830 rs2758312 chr6:160153452 G/A cg16489826 chr6:160211363 TCP1;MRPL18 0.5 6.25 0.33 1.28e-9 Age-related macular degeneration (geographic atrophy); CRC cis rs73206853 0.841 rs16940885 chr12:110971666 A/G cg12870014 chr12:110450643 ANKRD13A -0.7 -7.91 -0.4 3.93e-14 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC cis rs12802200 0.561 rs7937217 chr11:571967 T/C cg09218773 chr11:619014 MUPCDH -0.36 -5.79 -0.3 1.64e-8 Systemic lupus erythematosus; CRC cis rs17253792 0.822 rs75288952 chr14:56034010 C/T cg01858014 chr14:56050164 KTN1 -0.87 -6.89 -0.36 2.87e-11 Putamen volume; CRC cis rs17253792 0.822 rs74609892 chr14:56053002 G/A cg01858014 chr14:56050164 KTN1 -0.88 -7.07 -0.36 9.07e-12 Putamen volume; CRC cis rs8180040 0.690 rs7640397 chr3:46989828 C/T cg02527881 chr3:46936655 PTH1R -0.43 -8.07 -0.41 1.37e-14 Colorectal cancer; CRC cis rs17818399 0.888 rs2346419 chr2:46845069 G/C cg06386533 chr2:46925753 SOCS5 0.41 5.62 0.3 4.13e-8 Height; CRC trans rs10983614 1.000 rs7867776 chr9:120072627 A/G cg15313956 chr14:91744445 CCDC88C 0.45 6.09 0.32 3.13e-9 Survival in pancreatic cancer; CRC cis rs6665290 0.935 rs12403236 chr1:227196502 C/G cg10327440 chr1:227177885 CDC42BPA -1.05 -24.32 -0.8 1.66e-75 Myeloid white cell count; CRC cis rs883565 0.569 rs6599273 chr3:38998552 T/G cg01426195 chr3:39028469 NA -0.42 -6.97 -0.36 1.74e-11 Handedness; CRC cis rs10924970 0.649 rs11590729 chr1:235422177 T/G cg09010748 chr1:235293032 TOMM20 -0.41 -5.66 -0.3 3.37e-8 Asthma; CRC cis rs4975616 0.869 rs467095 chr5:1336221 T/C cg06550200 chr5:1325588 CLPTM1L -0.7 -11.02 -0.52 3.12e-24 Lung cancer; CRC cis rs9368481 0.761 rs9348746 chr6:26970357 C/G cg10547057 chr6:26987810 LOC100270746;C6orf41 -0.44 -6.25 -0.33 1.25e-9 Autism spectrum disorder or schizophrenia; CRC cis rs4665809 1.000 rs4665820 chr2:26309150 T/C cg04944784 chr2:26401820 FAM59B -0.6 -7.77 -0.39 1.01e-13 Gut microbiome composition (summer); CRC trans rs17607347 0.697 rs7204260 chr16:72384689 A/G cg27230510 chr3:50404023 CACNA2D2 -0.54 -6.09 -0.32 3.08e-9 Intelligence (multi-trait analysis); CRC trans rs7618501 1.000 rs7374277 chr3:49784777 T/C cg21582582 chr3:182698605 DCUN1D1 -0.57 -8.4 -0.42 1.38e-15 Intelligence (multi-trait analysis); CRC cis rs1577917 0.959 rs16876540 chr6:86612519 G/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.58 -7.17 -0.37 5.12e-12 Response to antipsychotic treatment; CRC trans rs10982213 0.830 rs2274163 chr9:117188714 C/T cg12595990 chr12:49351331 ARF3 0.4 6.23 0.32 1.4e-9 Interleukin-6 levels; CRC cis rs3018066 0.748 rs7678847 chr4:106987426 A/G cg01869342 chr4:106983673 TBCK 0.44 6.71 0.35 8.61e-11 Cancer; CRC cis rs7615952 0.641 rs6805074 chr3:125772274 T/A cg04553112 chr3:125709451 NA -0.51 -5.89 -0.31 9.55e-9 Blood pressure (smoking interaction); CRC cis rs7085104 0.660 rs7902804 chr10:104585405 A/T cg23093090 chr10:104574429 C10orf26 -0.43 -6.82 -0.35 4.43e-11 Immature fraction of reticulocytes;Schizophrenia; CRC cis rs12142240 0.731 rs6658556 chr1:46844180 A/C cg14993813 chr1:46806288 NSUN4 -0.5 -6.2 -0.32 1.74e-9 Menopause (age at onset); CRC cis rs7605827 0.930 rs2287264 chr2:15637592 C/G cg19274914 chr2:15703543 NA 0.4 6.05 0.32 4e-9 Educational attainment (years of education); CRC cis rs4665809 0.627 rs13014338 chr2:26463024 C/T cg26119090 chr2:26468346 HADHA;HADHB 1.06 15.5 0.65 4.69e-41 Gut microbiome composition (summer); CRC cis rs13108904 0.935 rs3755920 chr4:1243617 T/C cg24560729 chr4:1342394 KIAA1530 0.32 5.76 0.3 1.88e-8 Obesity-related traits; CRC cis rs7224685 0.501 rs781842 chr17:3958955 C/T cg09597638 chr17:3907349 NA 0.64 11.73 0.54 8.96e-27 Type 2 diabetes; CRC cis rs10504229 1.000 rs73607874 chr8:58173433 G/C cg24829409 chr8:58192753 C8orf71 -0.68 -11.34 -0.53 2.27e-25 Developmental language disorder (linguistic errors); CRC cis rs1278769 0.735 rs9577395 chr13:113534984 C/G cg00823993 chr13:113535758 ATP11A 0.66 8.75 0.43 1.14e-16 Interstitial lung disease; CRC cis rs11958404 0.929 rs72816533 chr5:157413352 G/T cg05962755 chr5:157440814 NA 0.89 11.91 0.55 1.94e-27 IgG glycosylation; CRC cis rs11716531 0.574 rs62256311 chr3:27271505 G/A cg02860705 chr3:27208620 NA 0.74 9.92 0.48 1.8899999999999998e-20 Diastolic blood pressure; CRC cis rs9291683 0.526 rs7695555 chr4:10001656 T/C cg11266682 chr4:10021025 SLC2A9 0.43 8.63 0.43 2.71e-16 Bone mineral density; CRC trans rs7580658 0.614 rs7585198 chr2:127962635 C/T cg03361557 chr19:19774500 ATP13A1 -0.41 -6.02 -0.31 4.68e-9 Protein C levels; CRC cis rs9467160 1.000 rs9461011 chr6:24440351 C/T cg20631270 chr6:24437470 GPLD1 -0.45 -5.98 -0.31 5.85e-9 Liver enzyme levels; CRC cis rs9649213 0.593 rs6973775 chr7:98004685 G/A cg21770322 chr7:97807741 LMTK2 0.52 8.48 0.42 7.87e-16 Prostate cancer (SNP x SNP interaction); CRC cis rs4665809 0.531 rs12990692 chr2:26464939 C/T cg04944784 chr2:26401820 FAM59B 0.87 11.85 0.55 3.24e-27 Gut microbiome composition (summer); CRC cis rs4664293 0.867 rs16822556 chr2:160600903 A/G cg08347373 chr2:160653686 CD302 -0.47 -7.43 -0.38 9.32e-13 Monocyte percentage of white cells; CRC cis rs13315871 0.790 rs13066409 chr3:58428444 A/G cg20936604 chr3:58311152 NA -0.72 -6.94 -0.36 2.09e-11 Cholesterol, total; CRC trans rs7618501 0.633 rs6771546 chr3:49968572 T/C cg21665057 chr3:196295764 WDR53;FBXO45 0.57 8.97 0.44 2.37e-17 Intelligence (multi-trait analysis); CRC trans rs2797160 1.000 rs983543 chr6:126005767 G/A cg05039488 chr6:79577232 IRAK1BP1 -0.49 -7.32 -0.37 1.91e-12 Endometrial cancer; CRC cis rs1215050 0.791 rs700738 chr4:98907909 C/A cg05340658 chr4:99064831 C4orf37 -0.47 -6.94 -0.36 2.06e-11 Waist-to-hip ratio adjusted for body mass index; CRC trans rs10842750 1.000 rs10842750 chr12:26690565 G/T cg08774802 chr16:691652 FAM195A 0.48 6.0 0.31 5.27e-9 Kashin-Beck disease; CRC cis rs9733 0.596 rs12086630 chr1:150650955 T/C cg18016565 chr1:150552671 MCL1 0.46 6.74 0.35 6.91e-11 Tonsillectomy; CRC cis rs2933343 0.729 rs1683780 chr3:128640239 C/T cg11901034 chr3:128598214 ACAD9 -0.56 -7.81 -0.4 7.72e-14 IgG glycosylation; CRC trans rs8002861 0.905 rs12875768 chr13:44428305 C/T cg17145862 chr1:211918768 LPGAT1 -0.72 -13.22 -0.59 2.74e-32 Leprosy; CRC cis rs2625529 0.652 rs2957728 chr15:72236432 G/T cg16672083 chr15:72433130 SENP8 0.47 7.01 0.36 1.39e-11 Red blood cell count; CRC trans rs11825064 0.520 rs2226891 chr11:134486796 T/G cg00033773 chr19:12779366 MORG1;C19orf56 0.45 6.2 0.32 1.69e-9 Seasonality; CRC cis rs13108904 0.901 rs7695691 chr4:1304632 A/G cg24560729 chr4:1342394 KIAA1530 0.32 5.62 0.3 4.15e-8 Obesity-related traits; CRC cis rs644799 0.965 rs549695 chr11:95617788 T/C cg03916912 chr11:95522834 CEP57;FAM76B 0.95 17.59 0.7 2.82e-49 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs3820068 0.603 rs59558854 chr1:15971399 T/G cg24675056 chr1:15929824 NA 0.53 7.22 0.37 3.68e-12 Systolic blood pressure; CRC trans rs877282 1.000 rs71494928 chr10:769134 A/G cg22713356 chr15:30763199 NA 1.32 16.33 0.67 2.65e-44 Uric acid levels; CRC cis rs9311474 0.502 rs4687624 chr3:52563572 C/T cg10802521 chr3:52805072 NEK4 -0.52 -8.08 -0.41 1.22e-14 Electroencephalogram traits; CRC cis rs832540 0.519 rs10039338 chr5:56260363 C/T cg24531977 chr5:56204891 C5orf35 0.51 8.32 0.42 2.31e-15 Coronary artery disease; CRC cis rs10504229 0.679 rs17804870 chr8:58158071 A/G cg08219700 chr8:58056026 NA 0.54 5.89 0.31 9.62e-9 Developmental language disorder (linguistic errors); CRC cis rs7618501 0.633 rs4688689 chr3:50035542 C/T cg05623727 chr3:50126028 RBM5 0.47 7.63 0.39 2.51e-13 Intelligence (multi-trait analysis); CRC cis rs875971 0.660 rs10215132 chr7:66054406 C/A cg11764359 chr7:65958608 NA -0.55 -8.66 -0.43 2.21e-16 Aortic root size; CRC cis rs7771547 0.573 rs546353 chr6:36398597 C/A cg07856975 chr6:36356162 ETV7 0.4 5.76 0.3 1.91e-8 Platelet distribution width; CRC cis rs2262909 0.962 rs439574 chr19:22232024 A/C cg11619707 chr19:22235551 ZNF257 -0.29 -5.86 -0.31 1.13e-8 Chagas cardiomyopathy in Tripanosoma cruzi seropositivity; CRC cis rs7107174 0.901 rs866901 chr11:77926309 C/T cg02023728 chr11:77925099 USP35 0.51 7.31 0.37 2.03e-12 Testicular germ cell tumor; CRC cis rs853679 0.517 rs9380052 chr6:28064623 A/G cg25164649 chr6:28176230 NA 0.75 9.29 0.46 2.13e-18 Depression; CRC cis rs425277 1.000 rs262670 chr1:2082458 C/T cg24578937 chr1:2090814 PRKCZ 0.66 11.73 0.54 8.84e-27 Height; CRC cis rs889398 0.617 rs11648348 chr16:69890722 G/A cg00738113 chr16:70207722 CLEC18C -0.35 -6.21 -0.32 1.58e-9 Body mass index; CRC cis rs12142240 0.698 rs17357628 chr1:46808462 A/G cg14993813 chr1:46806288 NSUN4 -0.49 -6.22 -0.32 1.5e-9 Menopause (age at onset); CRC cis rs524281 0.861 rs10791858 chr11:65978396 A/G cg14541915 chr11:65894463 PACS1 0.34 5.65 0.3 3.39e-8 Electroencephalogram traits; CRC cis rs7586879 0.828 rs1865688 chr2:25108245 C/G cg22495460 chr2:25135724 ADCY3 -0.88 -15.31 -0.64 2.55e-40 Body mass index; CRC cis rs7119 0.717 rs11630916 chr15:77821331 G/A cg27398640 chr15:77910606 LINGO1 -0.46 -8.02 -0.4 1.85e-14 Type 2 diabetes; CRC cis rs6502050 0.835 rs66932937 chr17:80116803 G/A cg19223190 chr17:80058835 NA 0.39 6.25 0.33 1.27e-9 Life satisfaction; CRC cis rs6502050 0.835 rs3924780 chr17:80112978 G/A cg09264619 chr17:80180166 NA -0.34 -5.81 -0.3 1.5e-8 Life satisfaction; CRC cis rs5769707 0.632 rs135877 chr22:50014002 A/G cg20744362 chr22:50050164 C22orf34 0.35 6.38 0.33 5.86e-10 Monocyte count;Monocyte percentage of white cells; CRC cis rs4665809 0.590 rs4665315 chr2:26416036 T/G cg04944784 chr2:26401820 FAM59B -0.82 -10.57 -0.5 1.14e-22 Gut microbiome composition (summer); CRC cis rs9467711 0.584 rs34391493 chr6:26022648 A/C cg08501292 chr6:25962987 TRIM38 0.79 7.3 0.37 2.19e-12 Autism spectrum disorder or schizophrenia; CRC cis rs2882667 0.931 rs1433009 chr5:138333784 G/A cg09476006 chr5:138032270 NA 0.42 6.8 0.35 4.96e-11 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs780096 0.526 rs13472 chr2:27600239 G/A cg27432699 chr2:27873401 GPN1 -0.61 -9.14 -0.45 6.74e-18 Total body bone mineral density; CRC cis rs875971 0.660 rs10281080 chr7:66042441 T/C cg18876405 chr7:65276391 NA -0.61 -11.09 -0.52 1.75e-24 Aortic root size; CRC cis rs172166 0.694 rs1631552 chr6:28089699 C/A cg17949981 chr6:28129498 ZNF389 0.41 5.63 0.3 3.84e-8 Cardiac Troponin-T levels; CRC cis rs7917772 0.636 rs7069489 chr10:104525371 A/G cg11453585 chr10:104263688 ACTR1A;SUFU 0.69 10.3 0.49 9.27e-22 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC cis rs7811142 0.830 rs75636500 chr7:99947657 C/G cg00814883 chr7:100076585 TSC22D4 -0.72 -8.55 -0.43 4.79e-16 Platelet count; CRC cis rs2742540 0.524 rs2653562 chr11:8918160 A/T cg12365402 chr11:9010492 NRIP3 -0.37 -6.08 -0.32 3.33e-9 Hematocrit; CRC trans rs1814175 0.791 rs7395713 chr11:49877887 A/G cg15704280 chr7:45808275 SEPT13 -1.01 -20.25 -0.74 8.67e-60 Height; CRC cis rs736801 0.808 rs2706396 chr5:131796809 A/C cg21138405 chr5:131827807 IRF1 0.35 6.04 0.32 4.13e-9 Breast cancer;Mosquito bite size; CRC cis rs6540559 1.000 rs2235373 chr1:209963803 G/A cg23283495 chr1:209979779 IRF6 0.47 7.15 0.37 5.7e-12 Cleft lip with or without cleft palate; CRC cis rs7223966 0.921 rs7225092 chr17:61864005 G/T cg23090583 chr17:61904693 PSMC5;FTSJ3 0.51 6.25 0.33 1.29e-9 Hip circumference adjusted for BMI;Body mass index; CRC trans rs3780486 0.846 rs10738905 chr9:33123627 A/G cg04842962 chr6:43655489 MRPS18A 1.16 25.88 0.82 2.46e-81 IgG glycosylation; CRC cis rs282587 0.569 rs7987086 chr13:113409889 G/A cg04656015 chr13:113407548 ATP11A 0.63 8.09 0.41 1.12e-14 Glycated hemoglobin levels; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg12859234 chr8:38089495 DDHD2 0.43 6.11 0.32 2.8e-9 Response to antipsychotic treatment; CRC cis rs9733 0.569 rs11588404 chr1:150688529 C/A cg10589385 chr1:150898437 SETDB1 0.28 5.96 0.31 6.66e-9 Tonsillectomy; CRC cis rs9287719 0.901 rs13034017 chr2:10739592 C/T cg00105475 chr2:10696890 NA 0.45 7.3 0.37 2.19e-12 Prostate cancer; CRC cis rs877282 0.583 rs11253441 chr10:828288 C/T cg17470449 chr10:769945 NA -0.59 -8.16 -0.41 7.24e-15 Uric acid levels; CRC cis rs10871290 0.881 rs11649338 chr16:74471420 C/T cg01733217 chr16:74700730 RFWD3 -0.68 -11.13 -0.52 1.19e-24 Breast cancer; CRC trans rs444386 1.000 rs444386 chr10:90528178 A/G cg05650238 chr5:55215955 NA -0.32 -6.14 -0.32 2.33e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs9325144 0.555 rs7301258 chr12:38706942 C/T cg26384229 chr12:38710491 ALG10B 0.52 7.88 0.4 4.92e-14 Morning vs. evening chronotype; CRC cis rs9649213 0.555 rs12667634 chr7:97965442 A/G cg00277769 chr7:97922759 BAIAP2L1 -0.59 -10.31 -0.49 9.12e-22 Prostate cancer (SNP x SNP interaction); CRC cis rs11098499 0.954 rs10518328 chr4:120401779 G/A cg09307838 chr4:120376055 NA 0.7 10.86 0.51 1.08e-23 Corneal astigmatism; CRC cis rs17065868 0.764 rs61949801 chr13:45040176 T/A cg10246903 chr13:45222710 NA 0.54 5.69 0.3 2.79e-8 Antineutrophil cytoplasmic antibody-associated vasculitis; CRC cis rs13191362 1.000 rs34773528 chr6:163088796 G/C cg14584255 chr6:163149320 PACRG;PARK2 0.44 6.29 0.33 1.02e-9 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs951366 0.668 rs823154 chr1:205762406 C/T cg11965913 chr1:205819406 PM20D1 0.93 16.28 0.67 3.89e-44 Menarche (age at onset); CRC cis rs2742417 0.624 rs2742394 chr3:45757591 C/T cg04837898 chr3:45731254 SACM1L -0.49 -7.9 -0.4 4.31e-14 Response to anti-depressant treatment in major depressive disorder; CRC cis rs6860806 0.507 rs272883 chr5:131668698 A/G cg09877947 chr5:131593287 PDLIM4 0.43 7.14 0.37 5.93e-12 Breast cancer; CRC cis rs9311676 0.632 rs4228 chr3:58413669 G/T cg06643156 chr3:58380774 PXK 0.42 6.45 0.33 4.08e-10 Systemic lupus erythematosus; CRC cis rs990171 1.000 rs11123931 chr2:103085660 A/G cg03938978 chr2:103052716 IL18RAP 0.47 5.93 0.31 7.82e-9 Lymphocyte counts; CRC cis rs16975963 0.639 rs112997435 chr19:38204631 C/T cg15135657 chr19:38346511 NA -0.46 -6.33 -0.33 7.91e-10 Longevity; CRC cis rs9399137 0.507 rs11154791 chr6:135379148 A/G cg24558204 chr6:135376177 HBS1L 0.62 9.14 0.45 6.73e-18 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; CRC cis rs7769051 0.711 rs9493435 chr6:133088205 A/G cg22852734 chr6:133119734 C6orf192 0.88 10.36 0.5 6.12e-22 Type 2 diabetes nephropathy; CRC cis rs853679 0.517 rs17711801 chr6:28092307 C/G cg15786705 chr6:28176104 NA 0.77 9.75 0.47 6.92e-20 Depression; CRC cis rs7618915 0.547 rs34017441 chr3:52742413 T/C cg15147215 chr3:52552868 STAB1 -0.62 -10.15 -0.49 2.99e-21 Bipolar disorder; CRC cis rs708547 0.647 rs1718839 chr4:57827206 A/G cg25525207 chr4:57843836 C4orf14;POLR2B -0.46 -6.51 -0.34 2.88e-10 Response to bleomycin (chromatid breaks); CRC cis rs2811415 0.597 rs2276867 chr3:127786675 T/G cg13719885 chr3:127795394 NA -0.39 -5.95 -0.31 6.69e-9 Lung function (FEV1/FVC); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg12504415 chr17:74722752 JMJD6;C17orf95 0.41 7.07 0.36 9.06e-12 Liver disease severity in Alagille syndrome; CRC cis rs10746514 0.833 rs2026302 chr1:232264047 A/G cg09506761 chr1:232265262 NA -0.47 -6.82 -0.35 4.48e-11 Response to statin therapy; CRC cis rs514406 0.895 rs1925673 chr1:53326984 T/G cg08859206 chr1:53392774 SCP2 -0.45 -7.04 -0.36 1.16e-11 Monocyte count; CRC cis rs72945132 0.619 rs61887436 chr11:70243337 C/T cg14191688 chr11:70257035 CTTN 0.67 8.71 0.43 1.49e-16 Coronary artery disease; CRC cis rs6456156 0.792 rs9366089 chr6:167512896 A/G cg07741184 chr6:167504864 NA 0.51 8.53 0.43 5.36e-16 Primary biliary cholangitis; CRC cis rs9420 0.961 rs499188 chr11:57434122 C/A cg23127183 chr11:57508653 C11orf31 -0.55 -7.77 -0.39 1e-13 Schizophrenia; CRC cis rs2576037 0.526 rs605487 chr18:44444778 G/C cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.55 9.36 0.46 1.25e-18 Personality dimensions; CRC cis rs10751667 0.621 rs10794348 chr11:939941 G/A cg23136738 chr11:925521 AP2A2 -0.41 -6.74 -0.35 7.27e-11 Alzheimer's disease (late onset); CRC cis rs989128 0.600 rs916978 chr17:48630452 T/C cg24438145 chr17:48624694 SPATA20 0.43 6.22 0.32 1.53e-9 Type 2 diabetes; CRC cis rs2070632 0.708 rs2248690 chr3:186330088 A/T cg25162301 chr3:186330055 AHSG -0.4 -5.75 -0.3 2.05e-8 Blood protein levels; CRC cis rs910316 1.000 rs11623413 chr14:75588824 C/T cg03030879 chr14:75389066 RPS6KL1 0.44 6.79 0.35 5.22e-11 Height; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg06254406 chr13:103450982 BIVM;KDELC1 0.46 6.39 0.33 5.65e-10 Response to antipsychotic treatment; CRC trans rs7726839 0.540 rs61580655 chr5:597564 A/G cg25482853 chr8:67687455 SGK3 1.06 12.52 0.57 1.15e-29 Obesity-related traits; CRC cis rs10540 1.000 rs61876326 chr11:467368 A/G cg15790184 chr11:494944 RNH1 0.59 6.1 0.32 2.95e-9 Body mass index; CRC cis rs72945132 0.678 rs35733235 chr11:70235595 C/T cg00319359 chr11:70116639 PPFIA1 0.56 5.68 0.3 2.97e-8 Coronary artery disease; CRC cis rs11628318 0.614 rs7149667 chr14:103129441 G/A cg12046867 chr14:103022105 NA 0.76 8.9 0.44 3.85e-17 Platelet count; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg09592155 chr17:8029700 NA 0.39 6.35 0.33 6.96e-10 Liver disease severity in Alagille syndrome; CRC cis rs1801251 1.000 rs13004406 chr2:233584557 A/T cg25237894 chr2:233734115 C2orf82 -0.53 -8.93 -0.44 3.08e-17 Coronary artery disease; CRC cis rs1448094 0.512 rs6539924 chr12:86236935 T/C cg25456477 chr12:86230367 RASSF9 0.32 5.6 0.3 4.42e-8 Major depressive disorder; CRC cis rs40363 1.000 rs1635393 chr16:3520493 C/T cg21433313 chr16:3507492 NAT15 0.77 8.71 0.43 1.47e-16 Tuberculosis; CRC cis rs28829049 0.597 rs2296107 chr1:19476649 C/G cg22333259 chr1:19394757 NA 0.36 5.66 0.3 3.34e-8 QRS duration in Tripanosoma cruzi seropositivity; CRC trans rs2303319 0.504 rs12467625 chr2:162603387 C/A cg27342122 chr8:133787442 PHF20L1 -0.72 -6.12 -0.32 2.68e-9 Cognitive function; CRC cis rs6964587 0.758 rs7798233 chr7:91500083 G/A cg17063962 chr7:91808500 NA -0.56 -6.77 -0.35 5.95e-11 Breast cancer; CRC cis rs6860806 0.507 rs270606 chr5:131650867 A/G cg20512303 chr5:131592959 PDLIM4 0.42 7.22 0.37 3.69e-12 Breast cancer; CRC trans rs7395662 0.724 rs10400308 chr11:48891246 G/T cg21153622 chr11:89784906 NA -0.48 -7.68 -0.39 1.79e-13 HDL cholesterol; CRC cis rs250677 0.617 rs166106 chr5:148447061 T/C cg23229984 chr5:148520753 ABLIM3 0.56 7.48 0.38 6.91e-13 Breast cancer; CRC cis rs728616 0.764 rs12413678 chr10:81687099 G/A cg05935833 chr10:81318306 SFTPA2 -0.7 -8.86 -0.44 5.1e-17 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs875971 0.789 rs10260426 chr7:65736042 G/T cg18252515 chr7:66147081 NA 0.4 5.71 0.3 2.52e-8 Aortic root size; CRC cis rs7264396 0.667 rs224368 chr20:34070380 A/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.38 -6.09 -0.32 3.2e-9 Total cholesterol levels; CRC cis rs9372498 0.536 rs10484286 chr6:118956447 T/C cg15382696 chr6:118971807 C6orf204 0.56 6.86 0.35 3.34e-11 Diastolic blood pressure; CRC cis rs3858526 0.523 rs10742818 chr11:5882535 T/C cg26762873 chr11:5879799 OR52E8 -0.5 -7.52 -0.38 5.2e-13 DNA methylation (variation); CRC trans rs1455244 0.700 rs7229302 chr18:11508904 G/T cg22800477 chr1:10853793 CASZ1 0.44 6.66 0.34 1.13e-10 Schizophrenia; CRC cis rs11758351 0.587 rs16891466 chr6:26235737 G/A cg08260959 chr6:26240920 HIST1H4F -0.35 -5.63 -0.3 3.78e-8 Gout;Renal underexcretion gout; CRC cis rs1215050 0.765 rs6852699 chr4:98767505 T/C cg05340658 chr4:99064831 C4orf37 0.46 6.75 0.35 6.5500000000000006e-11 Waist-to-hip ratio adjusted for body mass index; CRC cis rs539514 0.612 rs1830760 chr13:76296625 G/A cg04757411 chr13:76259545 LMO7 -0.37 -6.29 -0.33 1.01e-9 Type 1 diabetes; CRC cis rs597539 0.617 rs686348 chr11:68636996 A/G cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.89 15.85 0.66 1.89e-42 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs1124376 0.935 rs9855900 chr3:20147172 C/T cg05072819 chr3:20081367 KAT2B 0.49 5.92 0.31 8.07e-9 Bipolar disorder and schizophrenia; CRC cis rs314370 0.818 rs13245899 chr7:100497131 A/G cg11635098 chr7:100497156 NA -0.54 -6.81 -0.35 4.58e-11 Resting heart rate; CRC cis rs9372498 0.536 rs62424195 chr6:118812108 T/A cg01339444 chr6:118972232 C6orf204 0.52 5.92 0.31 8.31e-9 Diastolic blood pressure; CRC cis rs7833986 1.000 rs34404111 chr8:57099190 T/C cg23139584 chr8:56987506 RPS20;SNORD54 0.62 7.69 0.39 1.77e-13 Height; CRC cis rs9921222 0.585 rs7195617 chr16:376781 A/G cg10349874 chr16:420996 TMEM8A;MRPL28 0.52 7.08 0.36 8.61e-12 Bone mineral density (spine);Bone mineral density; CRC cis rs7725052 0.609 rs4495224 chr5:40477515 C/A cg09067459 chr5:40385259 NA 0.4 6.68 0.35 9.91e-11 Pediatric autoimmune diseases; CRC trans rs2727020 0.658 rs4980442 chr11:49445016 G/T cg11707556 chr5:10655725 ANKRD33B -0.39 -7.31 -0.37 2.08e-12 Coronary artery disease; CRC cis rs2398893 0.883 rs34169833 chr9:96840611 G/A cg14459158 chr9:96720562 NA 0.44 7.25 0.37 2.93e-12 Waist-hip ratio;Waist-to-hip ratio adjusted for body mass index; CRC cis rs1552244 1.000 rs76041173 chr3:10078695 G/T cg08888203 chr3:10149979 C3orf24 0.73 10.0 0.48 9.76e-21 Alzheimer's disease; CRC trans rs7591064 0.505 rs6545089 chr2:49198934 C/A cg05049280 chr1:110155535 GNAT2 0.41 6.02 0.31 4.78e-9 Radiation response; CRC cis rs877282 0.945 rs10904554 chr10:786768 T/C cg17470449 chr10:769945 NA 0.66 8.59 0.43 3.44e-16 Uric acid levels; CRC cis rs72627509 0.857 rs781658 chr4:57779567 G/A cg26694713 chr4:57773883 REST 0.46 5.68 0.3 3e-8 Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); CRC cis rs875971 0.862 rs6460279 chr7:65662761 T/C cg18252515 chr7:66147081 NA 0.41 5.72 0.3 2.34e-8 Aortic root size; CRC trans rs1997103 0.954 rs2177809 chr7:55378125 T/C cg20935933 chr6:143382018 AIG1 0.53 6.76 0.35 6.45e-11 QRS interval (sulfonylurea treatment interaction); CRC cis rs6570726 0.935 rs397418 chr6:145842362 C/T cg23711669 chr6:146136114 FBXO30 0.69 12.31 0.56 6.55e-29 Lobe attachment (rater-scored or self-reported); CRC cis rs13191362 0.935 rs66923841 chr6:163177317 C/T cg23758597 chr6:163146217 PARK2 -0.69 -7.08 -0.36 8.87e-12 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC trans rs1005277 0.522 rs289648 chr10:37971837 T/C cg17830980 chr10:43048298 ZNF37B -0.45 -7.01 -0.36 1.37e-11 Extrinsic epigenetic age acceleration; CRC cis rs2243480 0.831 rs57294491 chr7:65684901 T/A cg18252515 chr7:66147081 NA 1.25 14.52 0.63 2.87e-37 Diabetic kidney disease; CRC cis rs2243480 1.000 rs431076 chr7:65600320 A/C cg12463550 chr7:65579703 CRCP 0.7 6.48 0.34 3.32e-10 Diabetic kidney disease; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg09909671 chr11:13689641 FAR1 -0.38 -6.01 -0.31 5.05e-9 Myopia (pathological); CRC cis rs9814567 0.896 rs4245907 chr3:134347876 C/G cg06109529 chr3:134205091 CEP63;ANAPC13 -0.67 -9.59 -0.47 2.35e-19 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg07425090 chr6:86353447 SYNCRIP 0.46 6.32 0.33 8.41e-10 Anxiety disorder; CRC cis rs13108904 0.935 rs4246685 chr4:1279727 T/C cg16405210 chr4:1374714 KIAA1530 -0.44 -6.05 -0.32 3.92e-9 Obesity-related traits; CRC cis rs9611565 0.559 rs8139993 chr22:41995335 T/C cg03806693 chr22:41940476 POLR3H -0.72 -9.39 -0.46 1.07e-18 Vitiligo; CRC cis rs802075 1.000 rs802072 chr6:49656000 G/A cg20364632 chr6:49636226 NA -0.36 -5.88 -0.31 9.95e-9 Bone mineral density (hip) and age at menarche; CRC cis rs910187 0.678 rs6122563 chr20:45813885 C/T cg27589058 chr20:45804311 EYA2 -0.39 -7.39 -0.38 1.21e-12 Migraine; CRC cis rs7647973 0.961 rs11130187 chr3:49307872 T/C cg20833759 chr3:49053208 WDR6;DALRD3 0.53 8.06 0.41 1.42e-14 Menarche (age at onset); CRC cis rs853679 0.546 rs483143 chr6:27846744 G/C cg19041857 chr6:27730383 NA -0.76 -7.29 -0.37 2.34e-12 Depression; CRC cis rs2565722 0.825 rs1247537 chr6:161251788 T/C cg03159191 chr6:161285451 NA -0.48 -5.83 -0.31 1.35e-8 Blood protein levels; CRC cis rs9287719 0.578 rs13425171 chr2:10731966 C/G cg00105475 chr2:10696890 NA 0.46 7.17 0.37 5.09e-12 Prostate cancer; CRC cis rs7208859 0.673 rs75142521 chr17:29240537 G/A cg13385521 chr17:29058706 SUZ12P 0.65 7.74 0.39 1.27e-13 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs3823572 0.564 rs10272270 chr7:133636174 A/T cg03336402 chr7:133662267 EXOC4 0.68 10.53 0.5 1.5e-22 Intelligence (multi-trait analysis); CRC cis rs4243830 0.737 rs4908909 chr1:6599041 C/T cg05709478 chr1:6581295 PLEKHG5 -0.5 -5.69 -0.3 2.83e-8 Body mass index; CRC cis rs1799949 0.965 rs33961729 chr17:41287924 C/A cg19454999 chr17:41278357 BRCA1;NBR2 0.54 8.28 0.42 3.06e-15 Menopause (age at onset); CRC cis rs9388451 0.874 rs3734634 chr6:126111800 G/A cg05901451 chr6:126070800 HEY2 -0.66 -11.52 -0.54 4.89e-26 Brugada syndrome; CRC cis rs6570726 1.000 rs6570699 chr6:145920732 G/A cg23711669 chr6:146136114 FBXO30 0.69 11.17 0.52 8.91e-25 Lobe attachment (rater-scored or self-reported); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg18115022 chr15:65822705 PTPLAD1 0.4 6.14 0.32 2.44e-9 Liver disease severity in Alagille syndrome; CRC cis rs9916302 0.861 rs593480 chr17:37453780 A/C cg00129232 chr17:37814104 STARD3 0.55 8.19 0.41 5.68e-15 Glomerular filtration rate (creatinine); CRC cis rs427941 0.659 rs2529373 chr7:101739618 A/G cg06246474 chr7:101738831 CUX1 0.46 7.23 0.37 3.35e-12 Plasma omega-3 polyunsaturated fatty acid level (eicosapentaenoic acid); CRC cis rs7666738 0.753 rs17483788 chr4:98985623 G/A cg05340658 chr4:99064831 C4orf37 0.6 9.41 0.46 8.57e-19 Colonoscopy-negative controls vs population controls; CRC cis rs11191270 0.554 rs11191274 chr10:104140350 G/A cg15320455 chr10:103880129 LDB1 0.87 7.27 0.37 2.7e-12 Intelligence (multi-trait analysis); CRC cis rs644799 0.540 rs10831419 chr11:95478037 A/G cg03916912 chr11:95522834 CEP57;FAM76B 0.66 9.92 0.48 1.81e-20 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC trans rs4332037 0.906 rs6461009 chr7:1952139 T/C cg11693508 chr17:37793320 STARD3 -0.6 -7.42 -0.38 1.03e-12 Bipolar disorder; CRC cis rs2576037 0.899 rs2246877 chr18:44577005 A/G cg24750912 chr18:44543259 TCEB3CL;KATNAL2 -0.32 -6.07 -0.32 3.58e-9 Personality dimensions; CRC cis rs13191362 1.000 rs13202339 chr6:163081812 G/A cg21926612 chr6:163149169 PACRG;PARK2 0.97 12.62 0.57 4.78e-30 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs3741151 0.892 rs2027763 chr11:73035799 A/G cg17517138 chr11:73019481 ARHGEF17 0.64 6.64 0.34 1.26e-10 GIP levels in response to oral glucose tolerance test (120 minutes); CRC cis rs9322193 0.567 rs7747457 chr6:150213502 T/A cg13206674 chr6:150067644 NUP43 0.52 7.12 0.37 6.64e-12 Lung cancer; CRC cis rs12024301 0.557 rs16861400 chr1:183619781 A/G cg11505048 chr1:183622726 RGL1;APOBEC4 0.81 7.0 0.36 1.42e-11 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs1218582 0.710 rs4845685 chr1:154878300 C/A cg03351412 chr1:154909251 PMVK 0.54 8.68 0.43 1.92e-16 Prostate cancer; CRC cis rs59918340 0.548 rs10102728 chr8:142205964 G/A cg18755752 chr8:142205143 DENND3 -0.52 -8.03 -0.4 1.8e-14 Immature fraction of reticulocytes; CRC cis rs28386778 0.863 rs9207 chr17:61823899 C/T cg06873352 chr17:61820015 STRADA 0.76 14.29 0.62 2.31e-36 Prudent dietary pattern; CRC cis rs2404602 0.611 rs2404734 chr15:76936165 T/C cg23625390 chr15:77176239 SCAPER -0.86 -13.26 -0.59 1.86e-32 Blood metabolite levels; CRC cis rs4481887 0.927 rs11204637 chr1:248492581 G/A cg00666640 chr1:248458726 OR2T12 0.48 8.08 0.41 1.24e-14 Common traits (Other); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G ch.2.1420302F chr2:62093097 NA -0.39 -6.0 -0.31 5.26e-9 Liver disease severity in Alagille syndrome; CRC cis rs6879260 1.000 rs729568 chr5:179732350 C/T cg13944838 chr5:179740914 GFPT2 0.69 10.89 0.51 8.69e-24 Height; CRC cis rs10504229 0.683 rs7460059 chr8:58111561 C/T cg05313129 chr8:58192883 C8orf71 -0.42 -5.85 -0.31 1.16e-8 Developmental language disorder (linguistic errors); CRC cis rs1862618 0.802 rs832560 chr5:56124423 T/A cg20203395 chr5:56204925 C5orf35 -0.66 -8.08 -0.41 1.25e-14 Initial pursuit acceleration; CRC cis rs9486719 0.901 rs760619 chr6:96857431 A/G cg06623918 chr6:96969491 KIAA0776 0.8 9.03 0.45 1.53e-17 Migraine;Coronary artery disease; CRC cis rs7677751 0.767 rs6554158 chr4:55066077 G/A cg13615338 chr4:55094005 PDGFRA 0.4 5.77 0.3 1.79e-8 Corneal astigmatism; CRC cis rs9296092 0.500 rs35150558 chr6:33519612 T/A cg13560919 chr6:33536144 NA -0.44 -6.21 -0.32 1.61e-9 Age at smoking initiation in chronic obstructive pulmonary disease; CRC cis rs59104589 0.617 rs3771561 chr2:242353704 A/G cg19488206 chr2:242435732 STK25 -0.44 -6.48 -0.34 3.36e-10 Fibrinogen levels; CRC cis rs4132509 1.000 rs10927043 chr1:243762208 C/T cg21452805 chr1:244014465 NA 0.46 6.09 0.32 3.14e-9 RR interval (heart rate); CRC cis rs6460942 1.000 rs6460938 chr7:12406808 T/G cg06484146 chr7:12443880 VWDE -0.74 -7.67 -0.39 1.91e-13 Coronary artery disease; CRC cis rs208520 0.802 rs208499 chr6:66932146 C/T cg07460842 chr6:66804631 NA -0.95 -12.38 -0.56 3.81e-29 Exhaled nitric oxide output; CRC cis rs6163 0.588 rs10786706 chr10:104500659 C/T cg11453585 chr10:104263688 ACTR1A;SUFU -0.49 -7.61 -0.39 2.98e-13 Waist circumference;Hip circumference; CRC cis rs651907 0.535 rs35810977 chr3:101531380 G/A cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.6 7.88 0.4 4.9e-14 Colorectal cancer; CRC cis rs600806 0.850 rs10858095 chr1:109962642 G/C cg23032129 chr1:109941072 SORT1 -0.29 -6.01 -0.31 4.82e-9 Intelligence (multi-trait analysis); CRC cis rs3785574 0.925 rs2727340 chr17:61970224 T/A cg06873352 chr17:61820015 STRADA 0.46 7.1 0.36 7.91e-12 Height; CRC cis rs459571 0.715 rs401826 chr9:136890591 C/T cg13789015 chr9:136890014 NCRNA00094 0.44 5.76 0.3 1.91e-8 Platelet distribution width; CRC cis rs720844 0.608 rs7564206 chr2:149333686 G/A cg09247360 chr2:149335327 NA 0.47 6.28 0.33 1.05e-9 Peripheral arterial disease (traffic-related air pollution interaction); CRC trans rs13402330 0.730 rs72828098 chr2:103394261 A/C cg02746748 chr4:906741 GAK -0.28 -6.1 -0.32 2.93e-9 Thiazide-induced adverse metabolic effects in hypertensive patients; CRC trans rs7615952 0.543 rs4645102 chr3:125424441 A/G cg00769240 chr8:12517080 NA -0.74 -10.37 -0.5 5.27e-22 Blood pressure (smoking interaction); CRC cis rs17345786 0.906 rs59359251 chr3:101146362 A/C cg11279151 chr3:101281821 RG9MTD1 -0.67 -8.41 -0.42 1.27e-15 Colonoscopy-negative controls vs population controls; CRC trans rs6561151 0.681 rs61959998 chr13:44462501 A/T cg12856521 chr11:46389249 DGKZ 0.75 10.39 0.5 4.5e-22 Crohn's disease; CRC cis rs1971762 0.583 rs11170648 chr12:54089660 C/T cg06632207 chr12:54070931 ATP5G2 0.39 6.72 0.35 8.1e-11 Height; CRC cis rs875971 0.545 rs73146609 chr7:65767464 A/G cg03233332 chr7:66118400 NA -0.42 -5.83 -0.31 1.3e-8 Aortic root size; CRC cis rs6952808 0.825 rs12669937 chr7:1939765 C/T cg02951883 chr7:2050386 MAD1L1 -0.68 -10.82 -0.51 1.56e-23 Bipolar disorder and schizophrenia; CRC cis rs8062405 0.690 rs7187604 chr16:28565953 A/G cg16576597 chr16:28551801 NUPR1 0.56 8.26 0.41 3.52e-15 Cognitive ability (multi-trait analysis);Cognitive ability; CRC trans rs875971 0.660 rs2191268 chr7:66110224 C/T cg00922727 chr6:109415123 C6orf182;SESN1 -0.39 -6.08 -0.32 3.34e-9 Aortic root size; CRC cis rs6951245 0.554 rs2070118 chr7:1132505 G/A cg20603222 chr7:1096387 C7orf50;GPR146 -0.46 -5.99 -0.31 5.44e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs9914988 0.943 rs7224870 chr17:27102620 A/G cg20469991 chr17:27169893 C17orf63 -0.48 -6.06 -0.32 3.76e-9 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs3741404 0.672 rs4980524 chr11:63959259 A/C cg14078730 chr11:63896557 MACROD1 0.34 5.63 0.3 3.87e-8 Platelet count; CRC cis rs6694672 0.764 rs672928 chr1:197198558 T/C cg13682187 chr1:196946512 CFHR5 0.49 6.92 0.36 2.31e-11 Asthma; CRC cis rs8031584 0.958 rs35256769 chr15:31237776 G/A cg08109568 chr15:31115862 NA -0.51 -8.36 -0.42 1.77e-15 Huntington's disease progression; CRC cis rs4975616 0.869 rs452384 chr5:1330840 T/C cg26373071 chr5:1325741 CLPTM1L 0.55 10.06 0.49 6.09e-21 Lung cancer; CRC cis rs801193 1.000 rs10274773 chr7:66133578 G/A cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.44 -6.46 -0.34 3.86e-10 Aortic root size; CRC cis rs35110281 0.600 rs11089092 chr21:45120994 A/C cg01579765 chr21:45077557 HSF2BP -0.33 -6.16 -0.32 2.09e-9 Mean corpuscular volume; CRC cis rs6424115 0.679 rs2294495 chr1:24075876 C/T cg08896387 chr1:24191740 FUCA1 0.47 5.98 0.31 5.91e-9 Immature fraction of reticulocytes; CRC cis rs478304 0.651 rs11227279 chr11:65495211 G/A cg27068330 chr11:65405492 SIPA1 -0.67 -10.22 -0.49 1.81e-21 Acne (severe); CRC cis rs477692 0.905 rs508360 chr10:131424969 A/G cg05714579 chr10:131428358 MGMT 0.61 8.82 0.44 6.62e-17 Response to temozolomide; CRC cis rs735539 0.718 rs7985552 chr13:21280738 A/T cg04906043 chr13:21280425 IL17D 0.43 6.4 0.33 5.33e-10 Dental caries; CRC cis rs2179367 0.959 rs9390677 chr6:149710497 T/C cg07828024 chr6:149772892 ZC3H12D -0.38 -6.01 -0.31 5.01e-9 Dupuytren's disease; CRC cis rs10504229 0.728 rs17216187 chr8:58158778 G/T cg02725872 chr8:58115012 NA -0.59 -9.18 -0.45 4.97e-18 Developmental language disorder (linguistic errors); CRC cis rs7107770 1.000 rs1025812 chr11:125088182 C/G cg27629782 chr11:125073726 PKNOX2 0.49 6.01 0.31 4.83e-9 Photic sneeze reflex; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg26894311 chr10:104153930 NFKB2 0.38 6.39 0.33 5.82e-10 Liver disease severity in Alagille syndrome; CRC cis rs853679 0.585 rs201000 chr6:27809159 C/T cg03623178 chr6:28175578 NA 0.58 6.39 0.33 5.64e-10 Depression; CRC cis rs2239547 0.521 rs9682464 chr3:52888485 C/T cg11645453 chr3:52864694 ITIH4 0.59 10.42 0.5 3.82e-22 Schizophrenia; CRC cis rs17443541 0.507 rs7594660 chr2:200468594 A/G cg03741458 chr2:200468445 NA -0.36 -5.77 -0.3 1.82e-8 Intelligence (multi-trait analysis); CRC cis rs73110464 0.505 rs2638503 chr12:53307369 C/G cg06553033 chr12:53270239 NA 0.41 5.61 0.3 4.23e-8 Cancer (pleiotropy); CRC cis rs10870270 0.956 rs7894 chr10:133769482 G/C cg08754478 chr10:133766260 PPP2R2D -0.66 -9.29 -0.46 2.22e-18 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; CRC cis rs4862750 0.872 rs9998172 chr4:187898773 T/C cg07414643 chr4:187882934 NA 0.38 6.68 0.35 9.92e-11 Lobe attachment (rater-scored or self-reported); CRC cis rs7617773 0.780 rs7653152 chr3:48362097 G/C cg11946769 chr3:48343235 NME6 0.73 9.79 0.47 4.97e-20 Coronary artery disease; CRC cis rs6499129 0.558 rs7191281 chr16:67655133 T/C cg26727032 chr16:67993705 SLC12A4 -0.6 -7.41 -0.38 1.04e-12 Waist-to-hip ratio adjusted for body mass index; CRC cis rs10504229 0.683 rs11781690 chr8:58132931 C/G cg02290350 chr8:58132656 NA -0.58 -8.16 -0.41 7.29e-15 Developmental language disorder (linguistic errors); CRC cis rs7312933 0.558 rs55702525 chr12:42814309 T/C cg19980929 chr12:42632907 YAF2 -0.41 -6.26 -0.33 1.22e-9 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CRC cis rs10256972 0.567 rs2949185 chr7:1209013 A/G cg09177884 chr7:1199841 ZFAND2A -0.51 -7.48 -0.38 7.04e-13 Longevity;Endometriosis; CRC cis rs2530545 0.531 rs59560152 chr7:34613107 C/T cg14401837 chr7:34697493 NPSR1 0.43 6.26 0.33 1.19e-9 IgG glycosylation; CRC cis rs35110281 0.715 rs2838353 chr21:45119228 C/T cg04455712 chr21:45112962 RRP1B 0.4 7.68 0.39 1.85e-13 Mean corpuscular volume; CRC cis rs6543140 0.929 rs6742530 chr2:103082280 G/A cg04239558 chr2:103089729 SLC9A4 0.37 6.59 0.34 1.72e-10 Blood protein levels; CRC cis rs6952808 1.000 rs6952808 chr7:1886535 C/G cg04267008 chr7:1944627 MAD1L1 -0.65 -9.53 -0.46 3.71e-19 Bipolar disorder and schizophrenia; CRC cis rs2404602 0.716 rs2404737 chr15:76872217 T/G cg22467129 chr15:76604101 ETFA -0.39 -6.46 -0.34 3.66e-10 Blood metabolite levels; CRC cis rs9894429 0.789 rs7219915 chr17:79591813 C/T cg18240062 chr17:79603768 NPLOC4 0.67 11.92 0.55 1.86e-27 Eye color traits; CRC cis rs3741404 0.609 rs666497 chr11:63869821 G/C cg19465662 chr11:63993652 NUDT22;TRPT1 0.6 9.34 0.46 1.5e-18 Platelet count; CRC cis rs6460942 0.915 rs6460907 chr7:12304449 G/A cg20607287 chr7:12443886 VWDE -0.44 -5.85 -0.31 1.2e-8 Coronary artery disease; CRC cis rs1448094 0.512 rs1584368 chr12:86245117 A/C cg02569458 chr12:86230093 RASSF9 0.41 7.02 0.36 1.27e-11 Major depressive disorder; CRC cis rs6499255 0.951 rs12596823 chr16:69634757 A/C cg00738113 chr16:70207722 CLEC18C -0.39 -5.66 -0.3 3.28e-8 IgE levels; CRC cis rs10274279 0.660 rs2021743 chr7:157381899 T/C cg26886268 chr7:157387156 PTPRN2 -0.44 -5.99 -0.31 5.6e-9 Myopia (pathological); CRC cis rs6484504 0.600 rs366758 chr11:31222499 A/C cg14844989 chr11:31128820 NA -0.34 -6.04 -0.32 4.26e-9 Red blood cell count; CRC cis rs62064224 0.714 rs11653974 chr17:30635002 T/C cg12855166 chr17:30846586 MYO1D -0.39 -6.57 -0.34 1.92e-10 Schizophrenia; CRC cis rs4132509 0.895 rs7556516 chr1:243782009 G/A cg21452805 chr1:244014465 NA 0.48 6.54 0.34 2.3e-10 RR interval (heart rate); CRC cis rs2479724 0.846 rs2254805 chr6:41846110 T/G cg17623882 chr6:41773611 USP49 -0.52 -8.67 -0.43 2.01e-16 Menarche (age at onset); CRC cis rs514406 0.929 rs555741 chr1:53318851 T/G cg27535305 chr1:53392650 SCP2 -0.37 -6.75 -0.35 6.5500000000000006e-11 Monocyte count; CRC cis rs2834256 0.625 rs2834248 chr21:35056766 G/A cg14850771 chr21:34775459 IFNGR2 -0.42 -6.17 -0.32 1.96e-9 Red cell distribution width; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg01029575 chr19:54641418 CNOT3 0.52 7.36 0.38 1.5e-12 Response to antipsychotic treatment; CRC cis rs12295403 0.964 rs34364314 chr11:18691674 G/A cg07538406 chr11:18686895 NA -0.42 -6.3 -0.33 9.66e-10 Ovarian reserve; CRC cis rs870825 0.616 rs55674580 chr4:185626605 C/G cg04058563 chr4:185651563 MLF1IP 0.72 9.38 0.46 1.12e-18 Blood protein levels; CRC cis rs7584330 0.554 rs4420668 chr2:238444793 G/A cg14458575 chr2:238380390 NA 0.52 7.25 0.37 2.95e-12 Prostate cancer; CRC cis rs2019137 0.560 rs7421852 chr2:113990261 G/A cg23564664 chr2:113997917 PAX8;LOC654433;LOC440839 -0.36 -5.83 -0.31 1.32e-8 Lymphocyte counts; CRC cis rs4819052 0.851 rs2236445 chr21:46678453 T/C cg19498844 chr21:46707878 POFUT2;LOC642852 0.75 10.73 0.51 3.22e-23 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs7833986 1.000 rs34230678 chr8:57083117 T/C cg23139584 chr8:56987506 RPS20;SNORD54 0.61 7.68 0.39 1.81e-13 Height; CRC cis rs4713118 0.662 rs9468276 chr6:28027688 A/C cg06470822 chr6:28175283 NA 0.95 13.56 0.6 1.43e-33 Parkinson's disease; CRC cis rs6748734 1.000 rs11898716 chr2:241828311 A/G cg16358738 chr2:241808595 AGXT -0.39 -5.82 -0.31 1.38e-8 Urinary metabolites; CRC cis rs7727544 0.901 rs55633655 chr5:131598756 T/G cg20512303 chr5:131592959 PDLIM4 0.29 5.72 0.3 2.43e-8 Blood metabolite levels; CRC cis rs9322193 0.926 rs9766562 chr6:150109845 C/G cg05861140 chr6:150128134 PCMT1 -0.43 -6.91 -0.36 2.53e-11 Lung cancer; CRC cis rs1957429 0.808 rs8009510 chr14:65351338 T/G cg23373153 chr14:65346875 NA 0.79 8.2 0.41 5.6e-15 Pediatric areal bone mineral density (radius); CRC cis rs7917772 0.636 rs4418737 chr10:104525123 A/G cg22532475 chr10:104410764 TRIM8 0.33 5.62 0.3 4e-8 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC cis rs71403859 0.502 rs34015581 chr16:71508229 T/A cg08717414 chr16:71523259 ZNF19 -0.82 -8.9 -0.44 3.83e-17 Post bronchodilator FEV1; CRC cis rs9787249 0.874 rs7520588 chr1:40214525 T/A cg02773041 chr1:40204384 PPIE 0.64 9.5 0.46 4.57e-19 Blood protein levels; CRC cis rs6867032 1.000 rs7729761 chr5:2015783 G/T cg26168224 chr5:2018326 NA 1.0 18.51 0.71 6.11e-53 Gut microbiome composition (winter); CRC cis rs7937682 1.000 rs11213973 chr11:111538903 A/T cg09085632 chr11:111637200 PPP2R1B -1.0 -20.26 -0.75 8.32e-60 Primary sclerosing cholangitis; CRC cis rs59104589 0.617 rs3771550 chr2:242302811 A/G cg19488206 chr2:242435732 STK25 0.43 6.38 0.33 5.86e-10 Fibrinogen levels; CRC trans rs916888 0.821 rs415430 chr17:44859144 C/T cg01341218 chr17:43662625 NA -0.83 -9.39 -0.46 1.03e-18 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs6076065 0.723 rs4815199 chr20:23347169 G/A cg11657817 chr20:23433608 CST11 0.43 6.34 0.33 7.66e-10 Facial morphology (factor 15, philtrum width); CRC cis rs66887589 0.837 rs7661498 chr4:120408108 T/C cg09307838 chr4:120376055 NA 0.55 8.48 0.42 7.81e-16 Diastolic blood pressure; CRC cis rs2303745 0.589 rs7246262 chr19:17392483 C/G cg27101125 chr19:17392770 ANKLE1 -0.32 -5.69 -0.3 2.81e-8 Systemic lupus erythematosus; CRC cis rs7916697 0.520 rs12246624 chr10:70036562 C/T cg06988349 chr10:69991859 ATOH7 0.39 6.79 0.35 5.21e-11 Optic disc area; CRC cis rs9399135 0.933 rs4559100 chr6:135324085 T/C cg22676075 chr6:135203613 NA 0.42 6.51 0.34 2.78e-10 Red blood cell count; CRC cis rs4919694 1.000 rs79254677 chr10:104691567 A/G cg04362960 chr10:104952993 NT5C2 1.09 10.21 0.49 1.97e-21 Arsenic metabolism; CRC cis rs2179367 0.887 rs2789488 chr6:149725290 A/G cg11245181 chr6:149772854 ZC3H12D 0.37 5.95 0.31 7.03e-9 Dupuytren's disease; CRC cis rs1862618 0.853 rs2113079 chr5:56157951 A/G cg12311346 chr5:56204834 C5orf35 -0.76 -10.0 -0.48 9.92e-21 Initial pursuit acceleration; CRC cis rs10504229 1.000 rs58371676 chr8:58189382 G/A cg05313129 chr8:58192883 C8orf71 -0.47 -6.99 -0.36 1.49e-11 Developmental language disorder (linguistic errors); CRC cis rs853679 0.628 rs9368560 chr6:28159960 T/C cg06470822 chr6:28175283 NA 0.99 14.14 0.61 8.85e-36 Depression; CRC trans rs2727020 0.688 rs2734002 chr11:49234162 A/G cg15704280 chr7:45808275 SEPT13 0.82 13.79 0.61 1.91e-34 Coronary artery disease; CRC trans rs561341 1.000 rs508192 chr17:30315147 C/T cg20587970 chr11:113659929 NA 1.32 16.93 0.68 1.11e-46 Hip circumference adjusted for BMI; CRC cis rs514406 0.560 rs1889033 chr1:53211887 A/G cg25767906 chr1:53392781 SCP2 0.42 6.67 0.35 1.09e-10 Monocyte count; CRC cis rs9372498 0.505 rs72956993 chr6:118949708 A/T cg01339444 chr6:118972232 C6orf204 0.54 6.01 0.31 4.89e-9 Diastolic blood pressure; CRC cis rs904251 0.797 rs2776878 chr6:37487273 G/A cg25019722 chr6:37503610 NA -0.49 -8.91 -0.44 3.44e-17 Cognitive performance; CRC cis rs7827545 1.000 rs6578235 chr8:135568022 C/T cg13086574 chr8:135490821 ZFAT -0.37 -6.32 -0.33 8.52e-10 Hypertension (SNP x SNP interaction); CRC cis rs4820294 1.000 rs713835 chr22:38064650 C/T cg21798802 chr22:38057573 PDXP 0.47 7.7 0.39 1.63e-13 Fat distribution (HIV); CRC cis rs10504229 1.000 rs67236942 chr8:58176525 T/C cg22535103 chr8:58192502 C8orf71 -0.82 -12.27 -0.56 9.63e-29 Developmental language disorder (linguistic errors); CRC cis rs8072100 1.000 rs4794016 chr17:45725931 T/A cg25173405 chr17:45401733 C17orf57 0.46 7.09 0.36 8.09e-12 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs17253792 0.822 rs75049893 chr14:56089158 A/G cg01858014 chr14:56050164 KTN1 -0.87 -7.23 -0.37 3.34e-12 Putamen volume; CRC cis rs6000550 0.954 rs13055107 chr22:37469821 G/A cg12253469 chr22:37420454 MPST 0.51 5.76 0.3 1.88e-8 Mean corpuscular volume;Mean corpuscular hemoglobin;Red cell distribution width; CRC cis rs875971 0.825 rs1860472 chr7:66082723 T/C cg00343986 chr7:65444356 GUSB -0.46 -6.27 -0.33 1.16e-9 Aortic root size; CRC cis rs10504229 0.683 rs58438731 chr8:58134790 C/T cg04204079 chr8:58130323 NA -0.45 -5.78 -0.3 1.71e-8 Developmental language disorder (linguistic errors); CRC cis rs887829 0.588 rs6715325 chr2:234635241 A/G cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.47 -7.48 -0.38 7.02e-13 Metabolic traits;Bilirubin levels;Cholelithiasis-related traits in sickle cell anemia;Metabolite levels;Total bilirubin levels in HIV-1 infection;Serum metabolite levels;Blood metabolite levels; CRC cis rs7605827 0.930 rs11681344 chr2:15711885 C/A cg19274914 chr2:15703543 NA 0.37 5.78 0.3 1.73e-8 Educational attainment (years of education); CRC cis rs2404602 0.679 rs12899871 chr15:76757347 T/C cg22467129 chr15:76604101 ETFA -0.45 -7.71 -0.39 1.46e-13 Blood metabolite levels; CRC cis rs6964587 0.839 rs13229273 chr7:91444472 G/A cg17063962 chr7:91808500 NA 0.66 10.56 0.5 1.21e-22 Breast cancer; CRC cis rs2228479 0.850 rs17227263 chr16:89810598 G/A cg06558623 chr16:89946397 TCF25 1.14 10.79 0.51 1.99e-23 Skin colour saturation; CRC cis rs2839186 0.564 rs4819215 chr21:47623573 G/A cg09417038 chr21:47716443 C21orf57 -0.35 -6.0 -0.31 5.17e-9 Testicular germ cell tumor; CRC cis rs4332037 0.539 rs11762636 chr7:2061111 C/A cg21155852 chr7:2048760 MAD1L1 -0.5 -6.69 -0.35 9.34e-11 Bipolar disorder; CRC cis rs2075371 0.835 rs1646724 chr7:134001875 T/G cg11752832 chr7:134001865 SLC35B4 0.5 7.72 0.39 1.41e-13 Mean platelet volume; CRC cis rs9303280 0.836 rs11557467 chr17:38028634 G/T cg20243544 chr17:37824526 PNMT 0.43 6.63 0.34 1.41e-10 Self-reported allergy; CRC trans rs2303319 0.504 rs62189052 chr2:162623869 C/G cg27342122 chr8:133787442 PHF20L1 -0.72 -6.09 -0.32 3.2e-9 Cognitive function; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg14881459 chr19:797693 PTBP1 0.44 6.13 0.32 2.54e-9 Anxiety disorder; CRC cis rs9479482 0.967 rs34006533 chr6:150350574 C/A cg25797454 chr6:150327115 RAET1K 0.38 6.42 0.33 4.77e-10 Alopecia areata; CRC cis rs769267 0.930 rs4808959 chr19:19572108 T/G cg02546618 chr19:19431379 KIAA0892;SF4 0.46 6.27 0.33 1.14e-9 Tonsillectomy; CRC cis rs9527 0.590 rs1926029 chr10:104855670 C/T cg15744005 chr10:104629667 AS3MT -0.32 -6.32 -0.33 8.34e-10 Arsenic metabolism; CRC cis rs6534441 0.824 rs6856467 chr4:125457781 T/C cg21609808 chr4:125404261 NA 0.38 5.75 0.3 2.07e-8 Major depressive disorder; CRC cis rs4363385 0.668 rs1933386 chr1:152959265 T/A cg25856811 chr1:152973957 SPRR3 -0.26 -7.23 -0.37 3.47e-12 Inflammatory skin disease; CRC cis rs3008870 1.000 rs2985817 chr1:67398607 G/C cg08660285 chr1:67390436 MIER1;WDR78 1.02 15.1 0.64 1.64e-39 Lymphocyte percentage of white cells; CRC cis rs6496667 0.821 rs7182338 chr15:90879810 C/T cg04176472 chr15:90893244 GABARAPL3 0.58 6.66 0.34 1.15e-10 Rheumatoid arthritis; CRC cis rs7617773 0.780 rs34749846 chr3:48347168 T/G cg11946769 chr3:48343235 NME6 0.73 9.71 0.47 9.45e-20 Coronary artery disease; CRC cis rs10876993 0.890 rs1585781 chr12:58056701 T/G cg18357645 chr12:58087776 OS9 0.59 8.27 0.41 3.44e-15 Celiac disease or Rheumatoid arthritis; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg13929263 chr20:36156140 BLCAP 0.43 6.21 0.32 1.62e-9 Anxiety disorder; CRC cis rs1218582 0.682 rs12144978 chr1:154850445 G/A cg09359103 chr1:154839909 KCNN3 -0.77 -12.56 -0.57 7.86e-30 Prostate cancer; CRC cis rs9925964 0.900 rs56813533 chr16:31070481 A/T cg02466173 chr16:30829666 NA 0.43 5.91 0.31 8.74e-9 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs1044826 0.642 rs2118981 chr3:139178853 A/G cg00490450 chr3:139108681 COPB2 0.44 6.61 0.34 1.51e-10 Obesity-related traits; CRC cis rs2996428 0.667 rs11578581 chr1:3770642 G/A cg17848003 chr1:3704513 LRRC47 0.39 5.72 0.3 2.45e-8 Red cell distribution width; CRC cis rs311392 0.833 rs6473917 chr8:55090430 A/G cg06042504 chr8:55087323 NA -0.43 -6.86 -0.35 3.43e-11 Pelvic organ prolapse (moderate/severe); CRC cis rs9326248 0.861 rs4938353 chr11:117046197 G/A cg11861562 chr11:117069780 TAGLN 0.34 6.41 0.33 4.94e-10 Blood protein levels; CRC cis rs2836950 0.520 rs11911087 chr21:40665192 G/A cg06238570 chr21:40685208 BRWD1 -0.6 -8.68 -0.43 1.8e-16 Menarche (age at onset); CRC cis rs600626 0.578 rs10793126 chr11:75453982 C/T cg24262691 chr11:75473276 NA -0.49 -6.65 -0.34 1.25e-10 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CRC cis rs7762018 0.891 rs3088346 chr6:170149793 T/C cg19338460 chr6:170058176 WDR27 -0.71 -7.8 -0.4 8.04e-14 Thiazide-induced adverse metabolic effects in hypertensive patients; CRC cis rs2153535 0.601 rs1737581 chr6:8539138 A/G cg21535247 chr6:8435926 SLC35B3 0.51 7.75 0.39 1.12e-13 Motion sickness; CRC cis rs2404602 0.669 rs12441484 chr15:77109875 G/A cg23625390 chr15:77176239 SCAPER 0.47 6.86 0.35 3.43e-11 Blood metabolite levels; CRC cis rs6951245 0.935 rs113365567 chr7:1108785 T/C cg24642844 chr7:1081250 C7orf50 -0.77 -9.3 -0.46 1.98e-18 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs12586317 0.620 rs12437439 chr14:35585669 C/A cg16230307 chr14:35515116 FAM177A1 0.84 9.71 0.47 8.84e-20 Psoriasis; CRC cis rs9322193 0.847 rs4870054 chr6:150169538 C/T cg07701084 chr6:150067640 NUP43 0.53 7.2 0.37 4.21e-12 Lung cancer; CRC cis rs73206853 0.764 rs28580853 chr12:110826209 C/G cg12870014 chr12:110450643 ANKRD13A 0.63 8.1 0.41 1.06e-14 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC cis rs72781680 0.611 rs55905755 chr2:24330264 T/C cg20701182 chr2:24300061 SF3B14 0.66 7.69 0.39 1.68e-13 Lymphocyte counts; CRC cis rs17209837 0.667 rs45605032 chr7:87090301 C/T cg00919237 chr7:87102261 ABCB4 -0.49 -6.03 -0.32 4.4e-9 Gallbladder cancer; CRC cis rs6121246 0.909 rs6119651 chr20:30259246 G/T cg13852791 chr20:30311386 BCL2L1 0.69 11.57 0.54 3.26e-26 Mean corpuscular hemoglobin; CRC cis rs10504229 0.683 rs73603877 chr8:58108428 C/T cg02725872 chr8:58115012 NA -0.66 -11.36 -0.53 1.84e-25 Developmental language disorder (linguistic errors); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg13700589 chr9:15511220 PSIP1 0.38 6.48 0.34 3.35e-10 Liver disease severity in Alagille syndrome; CRC cis rs2073300 0.609 rs12625164 chr20:23354269 T/C cg12062639 chr20:23401060 NAPB 0.71 6.7 0.35 9.01e-11 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs12142240 0.698 rs3991877 chr1:46853749 C/A cg14993813 chr1:46806288 NSUN4 -0.48 -6.03 -0.32 4.47e-9 Menopause (age at onset); CRC cis rs9443645 0.901 rs2174742 chr6:79610101 G/T cg09184832 chr6:79620586 NA -0.48 -8.96 -0.44 2.53e-17 Intelligence (multi-trait analysis); CRC cis rs60871478 0.838 rs7789321 chr7:800977 A/G cg13798912 chr7:905769 UNC84A 0.56 6.28 0.33 1.1e-9 Cerebrospinal P-tau181p levels; CRC cis rs881375 0.967 rs1860823 chr9:123659304 T/C cg09586646 chr9:123605570 PSMD5;LOC253039 0.53 7.18 0.37 4.57e-12 Rheumatoid arthritis; CRC cis rs853679 0.517 rs9380058 chr6:28127444 T/C cg03623178 chr6:28175578 NA 0.97 12.38 0.56 3.55e-29 Depression; CRC cis rs6963495 0.769 rs73192134 chr7:105189338 T/C cg02135003 chr7:105160482 PUS7 -0.94 -12.71 -0.57 2.14e-30 Bipolar disorder (body mass index interaction); CRC cis rs12477438 0.765 rs7591794 chr2:99567514 T/C cg14399236 chr2:99771627 LIPT1;TSGA10 -0.6 -8.35 -0.42 1.87e-15 Chronic sinus infection; CRC cis rs17270561 0.609 rs9393655 chr6:25711338 A/G cg17691542 chr6:26056736 HIST1H1C 0.64 8.24 0.41 4.16e-15 Iron status biomarkers; CRC cis rs6499129 0.764 rs16957291 chr16:67326102 T/A cg26727032 chr16:67993705 SLC12A4 -0.53 -6.33 -0.33 7.81e-10 Waist-to-hip ratio adjusted for body mass index; CRC cis rs28386778 0.897 rs2584615 chr17:61927774 T/C cg25654072 chr17:61904446 PSMC5;FTSJ3 0.69 10.71 0.51 3.81e-23 Prudent dietary pattern; CRC cis rs12048904 0.964 rs3188491 chr1:101338482 A/G cg00063077 chr1:101360652 SLC30A7;EXTL2 0.51 7.5 0.38 5.9e-13 Multiple sclerosis; CRC cis rs2302190 0.882 rs2270098 chr17:56572081 C/T cg25885038 chr17:56607967 SEPT4 -0.51 -7.65 -0.39 2.21e-13 Vitamin D levels; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg10999867 chr6:114292751 HDAC2 0.45 6.47 0.34 3.61e-10 Response to antipsychotic treatment; CRC cis rs727505 0.607 rs10464674 chr7:124791551 A/G cg23710748 chr7:124431027 NA -0.64 -10.26 -0.49 1.34e-21 Lewy body disease; CRC cis rs6546550 0.933 rs6546555 chr2:70135760 A/G cg02498382 chr2:70120550 SNRNP27 -0.56 -9.49 -0.46 4.98e-19 Prevalent atrial fibrillation; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg14497348 chr9:6757781 KDM4C 0.41 6.05 0.32 4.01e-9 Intelligence (multi-trait analysis); CRC cis rs11105298 0.891 rs1054807 chr12:89913419 C/T cg00757033 chr12:89920650 WDR51B 0.37 6.08 0.32 3.37e-9 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; CRC trans rs9929218 0.954 rs34097984 chr16:68824148 T/G cg04657470 chr2:198365150 HSPE1;HSPD1 -0.77 -11.19 -0.53 7.43e-25 Colorectal cancer; CRC cis rs270601 0.955 rs273911 chr5:131661526 C/G cg04518342 chr5:131593106 PDLIM4 0.43 7.03 0.36 1.17e-11 Acylcarnitine levels; CRC cis rs9549260 0.564 rs4943808 chr13:41293950 C/T cg21288729 chr13:41239152 FOXO1 0.42 6.58 0.34 1.82e-10 Red blood cell count; CRC cis rs6860806 0.507 rs274570 chr5:131713226 C/T cg22638593 chr5:131593259 PDLIM4 -0.38 -6.16 -0.32 2.13e-9 Breast cancer; CRC cis rs28386778 0.897 rs2584617 chr17:61925298 C/T cg06873352 chr17:61820015 STRADA 0.75 14.17 0.62 6.74e-36 Prudent dietary pattern; CRC trans rs13418717 0.793 rs3795874 chr2:127656383 A/G cg05987030 chr3:137834655 DZIP1L -0.74 -6.21 -0.32 1.58e-9 Heart failure; CRC cis rs75422866 0.510 rs73104197 chr12:48111056 T/G cg14736327 chr12:48174669 SLC48A1 -0.73 -5.76 -0.3 1.94e-8 Pneumonia; CRC cis rs736801 0.740 rs17622378 chr5:131778452 A/G cg02033258 chr5:131593261 PDLIM4 0.32 5.65 0.3 3.47e-8 Breast cancer;Mosquito bite size; CRC cis rs9399135 0.507 rs2072825 chr6:135253451 A/G cg22676075 chr6:135203613 NA -0.65 -10.08 -0.49 5.16e-21 Red blood cell count; CRC cis rs916888 0.773 rs199448 chr17:44809001 A/G cg15921436 chr17:44337874 NA 0.79 8.61 0.43 3.12e-16 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs1552244 0.935 rs7649243 chr3:10089470 T/A cg13047869 chr3:10149882 C3orf24 0.57 7.8 0.4 8.27e-14 Alzheimer's disease; CRC cis rs7580658 0.963 rs9789510 chr2:128137012 G/A cg09760422 chr2:128146352 NA -0.36 -7.02 -0.36 1.25e-11 Protein C levels; CRC cis rs2836974 0.897 rs7280375 chr21:40552408 C/T cg11644478 chr21:40555479 PSMG1 -0.82 -12.74 -0.57 1.68e-30 Cognitive function; CRC cis rs4665809 1.000 rs6546767 chr2:26328746 A/G cg27170947 chr2:26402098 FAM59B -0.45 -5.97 -0.31 6.09e-9 Gut microbiome composition (summer); CRC cis rs7107174 1.000 rs7116698 chr11:77995191 T/C cg02023728 chr11:77925099 USP35 0.55 8.37 0.42 1.72e-15 Testicular germ cell tumor; CRC cis rs2576037 0.583 rs11660085 chr18:44529603 A/G cg23996704 chr18:44553084 KATNAL2 0.39 7.67 0.39 1.93e-13 Personality dimensions; CRC cis rs2976388 0.590 rs11785290 chr8:143814849 A/G cg12516270 chr8:143859308 LYNX1 -0.4 -6.69 -0.35 9.56e-11 Urinary tract infection frequency; CRC cis rs853679 0.517 rs9380065 chr6:28144751 A/G cg12273811 chr6:28175739 NA 0.72 9.03 0.45 1.47e-17 Depression; CRC cis rs372883 0.530 rs2832302 chr21:30749793 G/T cg24692254 chr21:30365293 RNF160 -0.52 -8.35 -0.42 1.97e-15 Pancreatic cancer; CRC cis rs7607369 0.714 rs55900247 chr2:219618708 T/C cg02176678 chr2:219576539 TTLL4 -0.57 -9.0 -0.44 1.87e-17 Red blood cell count;Amyotrophic lateral sclerosis; CRC cis rs887829 0.569 rs4294999 chr2:234635467 A/G cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.51 -8.26 -0.41 3.49e-15 Metabolic traits;Bilirubin levels;Cholelithiasis-related traits in sickle cell anemia;Metabolite levels;Total bilirubin levels in HIV-1 infection;Serum metabolite levels;Blood metabolite levels; CRC cis rs6570726 0.935 rs369214 chr6:145856709 G/A cg23711669 chr6:146136114 FBXO30 0.7 12.46 0.57 1.81e-29 Lobe attachment (rater-scored or self-reported); CRC cis rs4253772 0.530 rs113258957 chr22:46663678 G/C cg24881330 chr22:46731750 TRMU 0.64 5.87 0.31 1.06e-8 LDL cholesterol;Cholesterol, total; CRC cis rs875971 0.964 rs778721 chr7:65845397 C/G cg11764359 chr7:65958608 NA 0.61 9.95 0.48 1.41e-20 Aortic root size; CRC cis rs6088813 1.000 rs6088821 chr20:33987576 G/A cg14752227 chr20:34000481 UQCC -0.37 -5.72 -0.3 2.33e-8 Height; CRC cis rs4713118 0.824 rs13211701 chr6:27750079 T/C cg06470822 chr6:28175283 NA 0.74 10.0 0.48 9.56e-21 Parkinson's disease; CRC cis rs2735413 0.875 rs4888736 chr16:78083784 T/C cg04733911 chr16:78082701 NA -0.45 -7.54 -0.38 4.5e-13 Systolic blood pressure (alcohol consumption interaction); CRC cis rs4563143 0.675 rs73029042 chr19:29267979 A/T cg12756686 chr19:29218302 NA 0.6 8.99 0.44 2.04e-17 Methadone dose in opioid dependence; CRC cis rs4713118 0.540 rs469227 chr6:27970705 A/C cg25164649 chr6:28176230 NA 0.62 8.82 0.44 6.67e-17 Parkinson's disease; CRC cis rs898097 0.841 rs12453162 chr17:80859971 C/T cg15369054 chr17:80825471 TBCD 0.53 8.57 0.43 4.22e-16 Breast cancer; CRC cis rs7072216 0.843 rs4400721 chr10:100147097 C/T cg26618903 chr10:100175079 PYROXD2 -0.39 -6.27 -0.33 1.11e-9 Metabolite levels; CRC cis rs1023500 0.552 rs133368 chr22:42463689 T/C cg25452165 chr22:42524984 CYP2D6 0.42 6.42 0.33 4.89e-10 Schizophrenia; CRC cis rs9326248 1.000 rs3736120 chr11:117032125 G/T cg10130564 chr11:117069849 TAGLN 0.37 7.0 0.36 1.46e-11 Blood protein levels; CRC cis rs17253792 1.000 rs28616134 chr14:56178802 G/A cg01858014 chr14:56050164 KTN1 -0.79 -6.09 -0.32 3.09e-9 Putamen volume; CRC cis rs12630931 1.000 rs11719084 chr3:31972165 T/G cg21375017 chr3:31988082 OSBPL10 0.43 5.9 0.31 8.82e-9 Periodontal disease-related phenotypes; CRC cis rs7772486 0.558 rs7753273 chr6:146066039 C/T cg13319975 chr6:146136371 FBXO30 0.63 9.11 0.45 8.18e-18 Lobe attachment (rater-scored or self-reported); CRC cis rs7945705 0.520 rs1984791 chr11:9035027 C/T cg12365402 chr11:9010492 NRIP3 0.45 6.83 0.35 4.23e-11 Hemoglobin concentration; CRC cis rs4268898 0.662 rs9917315 chr2:24431501 C/A cg06627628 chr2:24431161 ITSN2 -0.85 -11.58 -0.54 3.01e-26 Asthma; CRC cis rs6582630 0.502 rs11520234 chr12:38255005 G/A cg13010199 chr12:38710504 ALG10B 0.45 5.75 0.3 2.07e-8 Drug-induced liver injury (flucloxacillin); CRC cis rs9368481 0.761 rs4713062 chr6:26948195 A/G cg12292205 chr6:26970375 C6orf41 -0.66 -10.65 -0.51 5.88e-23 Autism spectrum disorder or schizophrenia; CRC cis rs853679 0.546 rs200948 chr6:27835272 T/C cg15845792 chr6:28175446 NA 0.73 6.16 0.32 2.08e-9 Depression; CRC trans rs1814175 0.715 rs1722007 chr11:49897319 T/C cg15704280 chr7:45808275 SEPT13 -0.97 -18.62 -0.72 2.27e-53 Height; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg06620269 chr17:2952258 NA 0.44 6.85 0.35 3.67e-11 Intelligence (multi-trait analysis); CRC cis rs1401999 0.966 rs2313216 chr3:183637251 C/T cg05044414 chr3:183734942 ABCC5 0.45 7.9 0.4 4.33e-14 Anterior chamber depth; CRC cis rs6951245 1.000 rs2363286 chr7:1091625 A/G cg07217954 chr7:1067459 C7orf50 0.52 5.61 0.3 4.3e-8 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg14938410 chr1:150521562 ADAMTSL4 0.47 6.13 0.32 2.47e-9 Thyroid stimulating hormone; CRC cis rs2404602 0.692 rs2117369 chr15:76748861 A/T cg23625390 chr15:77176239 SCAPER 0.49 7.24 0.37 3.12e-12 Blood metabolite levels; CRC cis rs4713118 0.513 rs149959 chr6:28013854 T/C cg18032046 chr6:28092343 ZSCAN16 -0.43 -5.79 -0.3 1.61e-8 Parkinson's disease; CRC cis rs9847710 0.566 rs2564951 chr3:53060449 C/T cg15147215 chr3:52552868 STAB1 0.45 5.88 0.31 1.03e-8 Ulcerative colitis; CRC cis rs9556958 0.635 rs4529985 chr13:99167120 G/C cg20750642 chr13:99100586 FARP1 0.4 6.03 0.32 4.44e-9 Educational attainment (years of education); CRC cis rs7666738 0.791 rs7377018 chr4:99034962 C/T cg17366294 chr4:99064904 C4orf37 0.44 7.47 0.38 7.18e-13 Colonoscopy-negative controls vs population controls; CRC cis rs910316 0.737 rs175084 chr14:75519175 C/T cg11812906 chr14:75593930 NEK9 -0.59 -9.14 -0.45 6.43e-18 Height; CRC cis rs13191362 1.000 rs34773528 chr6:163088796 G/C cg21926612 chr6:163149169 PACRG;PARK2 0.97 12.48 0.57 1.63e-29 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs290268 0.874 rs290997 chr9:93559351 G/A cg02608019 chr9:93564028 SYK 0.45 7.07 0.36 9.36e-12 Platelet count; CRC cis rs9311474 0.507 rs4687644 chr3:52746541 T/G cg08222913 chr3:52553049 STAB1 -0.33 -6.12 -0.32 2.64e-9 Electroencephalogram traits; CRC cis rs9768139 0.935 rs7809076 chr7:158118438 C/T cg25566285 chr7:158114605 PTPRN2 -0.59 -10.17 -0.49 2.56e-21 Calcium levels; CRC cis rs34526934 0.608 rs7606110 chr2:177028551 T/C cg25347419 chr2:177043501 NA -0.48 -6.39 -0.33 5.66e-10 Obstructive sleep apnea trait (apnea hypopnea index); CRC cis rs9309473 1.000 rs10179134 chr2:73637519 A/G cg20560298 chr2:73613845 ALMS1 -0.47 -5.85 -0.31 1.21e-8 Metabolite levels; CRC cis rs727563 0.635 rs5758444 chr22:42133921 T/A cg03806693 chr22:41940476 POLR3H 0.99 12.34 0.56 5.14e-29 Crohn's disease;Inflammatory bowel disease; CRC cis rs7613875 0.578 rs2624822 chr3:50107219 T/C cg05623727 chr3:50126028 RBM5 -0.57 -9.85 -0.48 3.07e-20 Body mass index; CRC cis rs6963495 0.818 rs117845382 chr7:105152040 T/C cg02135003 chr7:105160482 PUS7 -0.9 -12.16 -0.56 2.37e-28 Bipolar disorder (body mass index interaction); CRC cis rs9309711 0.621 rs11127428 chr2:3471146 T/C cg15506890 chr2:3487001 NA -0.52 -8.27 -0.41 3.35e-15 Neurofibrillary tangles; CRC cis rs3026101 0.671 rs1806239 chr17:5295528 T/C cg25236894 chr17:5323110 RPAIN;NUP88 0.42 6.84 0.35 3.98e-11 Body mass index; CRC cis rs1656402 1.000 rs1729246 chr2:233426816 T/G cg03852847 chr2:233439513 NA 0.45 7.73 0.39 1.34e-13 Non-small cell lung cancer (survival); CRC cis rs1395 0.634 rs72817542 chr2:27526681 C/G cg14242246 chr2:27434262 C2orf28;SLC5A6 0.36 5.79 0.3 1.64e-8 Blood metabolite levels; CRC cis rs3087591 1.000 rs6505234 chr17:29688299 G/A cg24425628 chr17:29625626 OMG;NF1 -0.86 -16.65 -0.68 1.37e-45 Hip circumference; CRC cis rs2811415 0.597 rs9821500 chr3:127734929 T/C cg13719885 chr3:127795394 NA -0.41 -6.14 -0.32 2.36e-9 Lung function (FEV1/FVC); CRC cis rs2549003 0.811 rs10072700 chr5:131816903 A/C cg00255919 chr5:131827918 IRF1 0.53 8.28 0.42 3.06e-15 Asthma (sex interaction); CRC cis rs738322 0.533 rs2284064 chr22:38547395 A/C cg03162506 chr22:38580953 NA 0.28 6.05 0.32 4.02e-9 Cutaneous nevi; CRC cis rs7666738 0.830 rs2865949 chr4:99039967 A/G cg17366294 chr4:99064904 C4orf37 0.44 7.5 0.38 6.02e-13 Colonoscopy-negative controls vs population controls; CRC cis rs13191362 0.935 rs34035978 chr6:163165336 G/C cg06582575 chr6:163149167 PACRG;PARK2 0.79 10.72 0.51 3.49e-23 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs9311474 0.508 rs17052256 chr3:52593119 A/G cg15147215 chr3:52552868 STAB1 -0.65 -11.31 -0.53 2.75e-25 Electroencephalogram traits; CRC cis rs9470366 0.509 rs4714001 chr6:36638175 G/A cg08179530 chr6:36648295 CDKN1A -0.6 -9.16 -0.45 5.58e-18 QRS duration; CRC cis rs7949030 0.596 rs11231137 chr11:62315699 G/A cg13298116 chr11:62369859 EML3;MTA2 0.6 9.46 0.46 6.09e-19 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; CRC cis rs7833986 0.501 rs2976012 chr8:56974343 T/C cg23139584 chr8:56987506 RPS20;SNORD54 0.91 12.57 0.57 7.49e-30 Height; CRC cis rs6541297 0.887 rs4846906 chr1:230284257 C/A cg05784532 chr1:230284198 GALNT2 0.56 6.89 0.35 2.9100000000000002e-11 Coronary artery disease; CRC cis rs34779708 0.966 rs12769575 chr10:35435927 A/T cg03585969 chr10:35415529 CREM 0.66 8.68 0.43 1.88e-16 Inflammatory bowel disease;Crohn's disease; CRC trans rs116095464 0.614 rs56299325 chr5:220594 C/T cg00938859 chr5:1591904 SDHAP3 0.68 7.39 0.38 1.24e-12 Breast cancer; CRC cis rs1129187 0.755 rs3818554 chr6:42934620 C/T cg27588902 chr6:42928151 GNMT -0.4 -7.37 -0.38 1.4e-12 Alzheimer's disease in APOE e4+ carriers; CRC cis rs62229266 0.557 rs4817760 chr21:37395301 T/C cg12218747 chr21:37451666 NA -0.41 -6.51 -0.34 2.78e-10 Mitral valve prolapse; CRC cis rs1008375 0.932 rs1008894 chr4:17704667 C/T cg04450456 chr4:17643702 FAM184B -0.38 -5.77 -0.3 1.79e-8 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs6546537 0.714 rs17036759 chr2:69767029 C/T cg10773587 chr2:69614142 GFPT1 -0.49 -6.3 -0.33 9.3e-10 Serum thyroid-stimulating hormone levels; CRC cis rs9435341 0.965 rs55924375 chr1:107566690 C/A cg14671364 chr1:107599128 PRMT6 0.52 7.12 0.37 6.62e-12 Facial morphology (factor 21, depth of nasal alae); CRC cis rs6570726 0.791 rs1509213 chr6:145783360 G/A cg13319975 chr6:146136371 FBXO30 0.47 7.15 0.37 5.57e-12 Lobe attachment (rater-scored or self-reported); CRC cis rs6951245 0.554 rs10270249 chr7:1151886 G/T cg24642844 chr7:1081250 C7orf50 -0.47 -6.16 -0.32 2.07e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs55726902 1.000 rs55726902 chr12:48196982 G/A cg14736327 chr12:48174669 SLC48A1 -0.58 -7.29 -0.37 2.39e-12 Allergic disease (asthma, hay fever or eczema); CRC cis rs9322193 0.962 rs2065664 chr6:150083621 A/G cg05861140 chr6:150128134 PCMT1 -0.42 -7.06 -0.36 1.02e-11 Lung cancer; CRC cis rs9837602 0.529 rs1087198 chr3:99524381 C/T cg07805332 chr3:99536008 MIR548G;C3orf26 0.52 7.75 0.39 1.12e-13 Breast cancer; CRC trans rs2324229 0.797 rs1180237 chr6:83943928 A/C cg03637622 chr5:179334771 TBC1D9B -0.43 -6.08 -0.32 3.39e-9 Platelet-derived growth factor BB levels; CRC cis rs11997175 0.583 rs12680811 chr8:33778426 A/C cg04338863 chr8:33670619 NA 0.42 6.34 0.33 7.39e-10 Body mass index; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg11589374 chr3:126398357 NA 0.53 6.93 0.36 2.26e-11 Thyroid stimulating hormone; CRC cis rs7258465 1.000 rs10409483 chr19:18590223 C/G cg06462663 chr19:18546047 ISYNA1 0.48 7.36 0.38 1.47e-12 Breast cancer; CRC cis rs1448094 0.838 rs11834294 chr12:86311958 C/T cg19622623 chr12:86230825 RASSF9 -0.4 -6.43 -0.33 4.53e-10 Major depressive disorder; CRC cis rs911119 0.955 rs6048930 chr20:23592492 T/C cg16589663 chr20:23618590 CST3 0.45 6.3 0.33 9.76e-10 Chronic kidney disease; CRC cis rs1499614 1.000 rs1267817 chr7:66110040 G/T cg12463550 chr7:65579703 CRCP 0.64 5.75 0.3 2e-8 Gout; CRC cis rs13191362 0.810 rs28360533 chr6:162996742 A/G cg23758597 chr6:163146217 PARK2 -0.56 -6.17 -0.32 1.98e-9 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs58688157 0.880 rs12272314 chr11:590648 A/G cg05309505 chr11:612837 IRF7 0.37 5.73 0.3 2.22e-8 Systemic lupus erythematosus; CRC cis rs853679 0.550 rs1150692 chr6:28173957 A/G cg12963246 chr6:28129442 ZNF389 0.44 5.64 0.3 3.66e-8 Depression; CRC cis rs10128264 0.902 rs1250582 chr10:80973447 G/T cg18737081 chr10:80999807 ZMIZ1 -0.33 -5.76 -0.3 1.94e-8 Response to methotrexate in juvenile idiopathic arthritis; CRC cis rs501120 0.584 rs11238923 chr10:44701232 A/T cg09554077 chr10:44749378 NA 0.69 7.87 0.4 5.01e-14 Coronary artery disease;Coronary heart disease; CRC cis rs9826463 0.582 rs11714528 chr3:142133218 C/T cg20824294 chr3:142316082 PLS1 0.38 6.03 0.32 4.36e-9 QRS duration in Tripanosoma cruzi seropositivity; CRC cis rs7224737 1.000 rs731152 chr17:40279680 G/A cg00647820 chr17:40259828 DHX58 -0.46 -6.59 -0.34 1.78e-10 Fibrinogen levels; CRC cis rs9318086 0.624 rs9510909 chr13:24436760 C/T cg25267304 chr13:24462978 PCOTH;MIPEP 0.62 10.07 0.49 5.54e-21 Myopia (pathological); CRC cis rs7937682 0.889 rs521155 chr11:111492563 G/A cg19812747 chr11:111475976 SIK2 -0.59 -10.14 -0.49 3.31e-21 Primary sclerosing cholangitis; CRC cis rs7917772 0.619 rs2801050 chr10:104509393 T/A cg22532475 chr10:104410764 TRIM8 -0.38 -6.26 -0.33 1.22e-9 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC trans rs3794271 0.706 rs9971816 chr12:20826911 C/T cg08336687 chr16:907744 LMF1 0.47 6.45 0.34 4.09e-10 Response to TNF-alpha inhibitors in rheumatoid arthritis; CRC trans rs2228479 0.850 rs11645916 chr16:89835234 G/A cg24644049 chr4:85504048 CDS1 0.87 7.12 0.37 7.01e-12 Skin colour saturation; CRC cis rs2066819 1.000 rs808919 chr12:56647911 C/G cg26734620 chr12:56694298 CS -0.61 -5.71 -0.3 2.52e-8 Psoriasis vulgaris; CRC cis rs6502050 0.731 rs76421195 chr17:80109326 T/C cg25804541 chr17:80189381 SLC16A3 -0.31 -5.97 -0.31 6.08e-9 Life satisfaction; CRC cis rs79057730 0.527 rs35316052 chr7:802954 C/T cg06242242 chr7:766104 PRKAR1B;HEATR2 0.66 6.33 0.33 8.06e-10 Initial pursuit acceleration; CRC cis rs344364 0.511 rs62040571 chr16:1948514 C/G cg00046913 chr16:1877150 HAGH;FAHD1 -0.58 -6.06 -0.32 3.66e-9 Glomerular filtration rate in chronic kidney disease; CRC cis rs863345 0.604 rs60104403 chr1:158500847 G/A cg12129480 chr1:158549410 OR10X1 -0.3 -6.21 -0.32 1.61e-9 Pneumococcal bacteremia; CRC cis rs9858542 0.953 rs11710037 chr3:49675334 C/G cg07274523 chr3:49395745 GPX1 0.47 6.07 0.32 3.48e-9 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs7833790 0.929 rs28464834 chr8:82797356 A/T cg27398817 chr8:82754497 SNX16 0.51 5.95 0.31 7e-9 Diastolic blood pressure; CRC cis rs10870270 1.000 rs7078692 chr10:133775370 T/A cg08754478 chr10:133766260 PPP2R2D -0.66 -9.21 -0.45 3.96e-18 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; CRC cis rs7618915 0.547 rs2289250 chr3:52682946 A/C cg08222913 chr3:52553049 STAB1 0.36 6.6 0.34 1.64e-10 Bipolar disorder; CRC trans rs1147246 0.714 rs323852 chr12:125877998 A/G cg23470196 chr14:102695671 RAGE 0.41 5.98 0.31 5.73e-9 Amyotrophic lateral sclerosis (sporadic); CRC cis rs11212617 0.967 rs6589017 chr11:108308504 A/G cg14761454 chr11:108092087 ATM;NPAT 0.39 5.66 0.3 3.24e-8 Response to metformin in type 2 diabetes (glycemic); CRC cis rs11098499 0.863 rs13140391 chr4:120503437 A/G cg24375607 chr4:120327624 NA 0.49 7.32 0.37 1.86e-12 Corneal astigmatism; CRC trans rs17685 0.743 rs10277259 chr7:75802674 A/C cg19862616 chr7:65841803 NCRNA00174 0.98 17.05 0.68 3.66e-47 Coffee consumption;Coffee consumption (cups per day); CRC cis rs13064411 0.696 rs7622740 chr3:113206771 G/A cg10517650 chr3:113235015 CCDC52 -0.4 -6.95 -0.36 1.94e-11 Response to simvastatin treatment (PCSK9 protein level change); CRC cis rs2204008 0.774 rs7304438 chr12:38361146 T/G cg13010199 chr12:38710504 ALG10B 0.47 6.3 0.33 9.77e-10 Bladder cancer; CRC trans rs2270927 0.510 rs67771044 chr5:75577819 A/G cg13563193 chr19:33072644 PDCD5 0.68 6.06 0.32 3.71e-9 Mean corpuscular volume; CRC cis rs1865760 0.593 rs3903852 chr6:25915147 G/T cg03517284 chr6:25882590 NA -0.45 -6.66 -0.34 1.15e-10 Height; CRC trans rs57221529 0.709 rs111352378 chr5:577079 G/A cg11887960 chr12:57824829 NA 0.62 6.76 0.35 6.26e-11 Lung disease severity in cystic fibrosis; CRC cis rs4888262 0.508 rs12598701 chr16:74539904 G/A cg01733217 chr16:74700730 RFWD3 0.75 11.29 0.53 3.42e-25 Testicular germ cell tumor; CRC cis rs375066 0.623 rs1909 chr19:44355517 C/T cg19542119 chr19:44331823 ZNF283 0.4 5.61 0.3 4.24e-8 Breast cancer; CRC cis rs8180040 0.726 rs4078466 chr3:47126543 C/T cg02527881 chr3:46936655 PTH1R -0.37 -6.89 -0.36 2.81e-11 Colorectal cancer; CRC cis rs9491140 0.539 rs11154230 chr6:124686156 A/G cg19267163 chr6:125004984 NKAIN2 0.44 6.01 0.31 4.88e-9 Neuroticism; CRC cis rs2735413 0.846 rs12923290 chr16:78079956 A/G cg04733911 chr16:78082701 NA -0.44 -7.37 -0.38 1.38e-12 Systolic blood pressure (alcohol consumption interaction); CRC cis rs929596 0.564 rs2602364 chr2:234524229 G/A cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.45 -6.1 -0.32 3.04e-9 Total bilirubin levels in HIV-1 infection; CRC cis rs13256369 0.802 rs11249884 chr8:8561552 C/T cg18904891 chr8:8559673 CLDN23 -0.51 -6.87 -0.35 3.27e-11 Obesity-related traits; CRC cis rs617791 0.508 rs2276132 chr11:65770545 G/A cg09783858 chr11:65769428 EIF1AD;BANF1 0.5 7.62 0.39 2.73e-13 Breast cancer; CRC cis rs7680126 0.596 rs10489070 chr4:10276352 C/G cg11266682 chr4:10021025 SLC2A9 -0.42 -6.5 -0.34 2.91e-10 Urate levels in lean individuals;Urate levels in overweight individuals;Urate levels in obese individuals; CRC cis rs13082711 1.000 rs34234262 chr3:27539188 G/A cg02860705 chr3:27208620 NA 0.58 7.53 0.38 4.97e-13 Systolic blood pressure;Diastolic blood pressure;Blood pressure; CRC cis rs1784581 0.588 rs7765624 chr6:162427462 C/A cg17173639 chr6:162384350 PARK2 0.6 9.3 0.46 2.06e-18 Itch intensity from mosquito bite; CRC cis rs919433 0.750 rs788012 chr2:198229856 A/T cg10820045 chr2:198174542 NA 0.45 7.78 0.39 9.61e-14 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC cis rs6502050 0.835 rs8065981 chr17:80091393 G/T cg09264619 chr17:80180166 NA -0.36 -6.04 -0.32 4.23e-9 Life satisfaction; CRC cis rs9322193 0.923 rs10782314 chr6:150056663 C/T cg07701084 chr6:150067640 NUP43 0.56 7.99 0.4 2.33e-14 Lung cancer; CRC cis rs12368653 0.693 rs2640610 chr12:58037435 T/A cg00700412 chr12:58011837 NA 0.4 6.29 0.33 9.87e-10 Multiple sclerosis; CRC cis rs2281845 0.929 rs6413915 chr1:201091041 A/C cg08885800 chr1:201084119 NA -0.47 -8.94 -0.44 2.87e-17 Permanent tooth development; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg23753457 chr11:69455870 CCND1 0.47 6.71 0.35 8.38e-11 Response to antipsychotic treatment; CRC cis rs763121 0.853 rs6001185 chr22:39052155 G/A cg06544989 chr22:39130855 UNC84B 0.45 6.86 0.35 3.39e-11 Menopause (age at onset); CRC trans rs1005277 0.579 rs2504143 chr10:38383706 C/T cg27523141 chr10:43048294 ZNF37B 0.49 7.18 0.37 4.61e-12 Extrinsic epigenetic age acceleration; CRC cis rs35883536 0.631 rs2783704 chr1:101040652 T/A cg06223162 chr1:101003688 GPR88 0.34 6.32 0.33 8.46e-10 Monocyte count; CRC cis rs1348850 0.872 rs4893959 chr2:178400204 G/A cg22681709 chr2:178499509 PDE11A -0.41 -7.48 -0.38 6.87e-13 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg25356086 chr21:33764900 C21orf119;URB1 0.5 7.24 0.37 3.29e-12 Response to antipsychotic treatment; CRC cis rs6951245 1.000 rs79617366 chr7:1111958 G/C cg18402987 chr7:1209562 NA 0.67 7.18 0.37 4.7e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs10504229 1.000 rs55787104 chr8:58178519 C/T cg22535103 chr8:58192502 C8orf71 -0.82 -12.28 -0.56 8.4e-29 Developmental language disorder (linguistic errors); CRC cis rs2842992 0.673 rs6930904 chr6:160217433 T/A cg11366901 chr6:160182831 ACAT2 0.92 13.23 0.59 2.5e-32 Age-related macular degeneration (geographic atrophy); CRC cis rs853679 0.574 rs1233705 chr6:28166447 C/G cg23161317 chr6:28129485 ZNF389 0.46 6.02 0.31 4.79e-9 Depression; CRC trans rs2797160 1.000 rs2211419 chr6:125995533 C/T cg05039488 chr6:79577232 IRAK1BP1 0.49 7.31 0.37 1.99e-12 Endometrial cancer; CRC trans rs71007656 1 rs71007656 chr10:37970845 CGGCTG/C cg27523141 chr10:43048294 ZNF37B 0.43 5.98 0.31 5.71e-9 Extrinsic epigenetic age acceleration; CRC trans rs7267979 1.000 rs2482931 chr20:25334445 G/A cg17903999 chr18:56338584 MALT1 0.42 6.79 0.35 5.11e-11 Liver enzyme levels (alkaline phosphatase); CRC cis rs7589728 0.514 rs74426843 chr2:88459388 C/T cg18490616 chr2:88469792 THNSL2 0.61 6.1 0.32 2.9e-9 Plasma clusterin levels; CRC cis rs3733585 0.638 rs6449155 chr4:9956547 T/G cg00071950 chr4:10020882 SLC2A9 -0.55 -9.75 -0.47 6.56e-20 Cleft plate (environmental tobacco smoke interaction); CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg06467769 chr19:37808668 NA -0.4 -6.11 -0.32 2.78e-9 Myopia (pathological); CRC cis rs315934 0.739 rs315920 chr2:113873018 A/G cg24553058 chr2:113831203 IL1F10 0.49 6.06 0.32 3.72e-9 Dysmenorrheic pain; CRC cis rs7914558 1.000 rs7077097 chr10:104945463 G/A cg15744005 chr10:104629667 AS3MT -0.33 -6.94 -0.36 2.04e-11 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs6582630 0.594 rs7308707 chr12:38450428 G/C cg26384229 chr12:38710491 ALG10B -0.54 -7.74 -0.39 1.25e-13 Drug-induced liver injury (flucloxacillin); CRC cis rs6500395 1.000 rs1477134 chr16:48706973 G/A cg04672837 chr16:48644449 N4BP1 -0.45 -6.63 -0.34 1.38e-10 Response to tocilizumab in rheumatoid arthritis; CRC trans rs7615952 0.512 rs2979336 chr3:125357470 G/A cg02007433 chr3:129722099 NA -0.61 -9.15 -0.45 6.13e-18 Blood pressure (smoking interaction); CRC cis rs1215050 0.791 rs684210 chr4:98678740 G/C cg05340658 chr4:99064831 C4orf37 0.47 7.01 0.36 1.4e-11 Waist-to-hip ratio adjusted for body mass index; CRC cis rs9292777 0.933 rs9292771 chr5:40434652 A/T cg09067459 chr5:40385259 NA 0.51 8.87 0.44 4.77e-17 Crohn's disease;Multiple sclerosis; CRC cis rs7727544 0.507 rs9791170 chr5:131569627 A/G cg12564285 chr5:131593104 PDLIM4 0.53 10.05 0.48 6.61e-21 Blood metabolite levels; CRC cis rs4243830 0.850 rs2063806 chr1:6610382 C/T cg05709478 chr1:6581295 PLEKHG5 -0.57 -6.81 -0.35 4.6e-11 Body mass index; CRC trans rs1814175 0.645 rs1608632 chr11:49967148 C/T cg15704280 chr7:45808275 SEPT13 -0.94 -16.56 -0.67 3.26e-45 Height; CRC cis rs10927875 0.632 rs1122068 chr1:16127480 G/C cg21385522 chr1:16154831 NA -1.07 -17.38 -0.69 1.88e-48 Dilated cardiomyopathy; CRC cis rs12701220 0.948 rs10275712 chr7:1082918 G/A cg00990874 chr7:1149470 C7orf50 -0.5 -5.91 -0.31 8.76e-9 Bronchopulmonary dysplasia; CRC cis rs72627123 0.749 rs10149956 chr14:74649106 A/G cg12022184 chr14:74485813 ENTPD5;C14orf45 -0.71 -5.61 -0.3 4.32e-8 Morning vs. evening chronotype; CRC cis rs2243480 0.901 rs2900904 chr7:65204264 C/G cg12463550 chr7:65579703 CRCP 0.67 6.13 0.32 2.58e-9 Diabetic kidney disease; CRC cis rs7223966 1.000 rs7214312 chr17:61870863 A/G cg23090583 chr17:61904693 PSMC5;FTSJ3 0.52 6.29 0.33 1e-9 Hip circumference adjusted for BMI;Body mass index; CRC cis rs7772486 0.686 rs857882 chr6:145969716 T/G cg23711669 chr6:146136114 FBXO30 -0.73 -12.39 -0.56 3.43e-29 Lobe attachment (rater-scored or self-reported); CRC cis rs4731207 0.596 rs3903522 chr7:124668142 G/A cg23710748 chr7:124431027 NA -0.39 -6.19 -0.32 1.82e-9 Cutaneous malignant melanoma; CRC cis rs13038095 1 rs13038095 chr20:46425576 A/C cg21798815 chr20:46414765 SULF2 -0.62 -6.23 -0.32 1.45e-9 Atrial fibrillation; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg22617550 chr15:89974231 NA 0.44 6.12 0.32 2.72e-9 Response to antipsychotic treatment; CRC cis rs8072100 0.512 rs9674670 chr17:45386157 G/A cg25173405 chr17:45401733 C17orf57 -0.59 -9.79 -0.47 4.97e-20 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs7904368 0.754 rs12246217 chr10:16853349 G/C cg23933602 chr10:16859644 RSU1 0.56 6.25 0.33 1.25e-9 Ratio of the peak velocity of the mitral E-Wave divided by the peak velocity of the mitral A-wave.; CRC cis rs1843834 0.931 rs10170573 chr2:225552916 A/G cg22455342 chr2:225449267 CUL3 0.48 6.38 0.33 6.04e-10 IgE levels in asthmatics (D.p. specific); CRC cis rs806215 1.000 rs806214 chr7:127237003 C/T cg25922125 chr7:127225783 GCC1 -0.68 -7.26 -0.37 2.85e-12 Type 2 diabetes; CRC cis rs10782582 0.593 rs6675212 chr1:76230829 C/A cg03433033 chr1:76189801 ACADM -0.45 -6.5 -0.34 3.03e-10 Daytime sleep phenotypes; CRC cis rs9287719 0.935 rs6751075 chr2:10723546 C/G cg00105475 chr2:10696890 NA 0.45 7.26 0.37 2.75e-12 Prostate cancer; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg07282944 chr12:48499338 SENP1;PFKM 0.46 6.36 0.33 6.56e-10 Response to antipsychotic treatment; CRC cis rs4363385 0.818 rs532743 chr1:153011758 T/G cg25856811 chr1:152973957 SPRR3 -0.25 -7.0 -0.36 1.49e-11 Inflammatory skin disease; CRC cis rs394563 0.726 rs6942381 chr6:149662991 G/C cg17885791 chr6:149771845 ZC3H12D 0.32 5.77 0.3 1.88e-8 Dupuytren's disease; CRC cis rs6570726 0.875 rs1883407 chr6:145823432 T/C cg23711669 chr6:146136114 FBXO30 0.69 12.05 0.55 6.08e-28 Lobe attachment (rater-scored or self-reported); CRC cis rs2032447 0.966 rs9358901 chr6:26024436 G/T cg26028573 chr6:26043587 HIST1H2BB 0.47 7.22 0.37 3.59e-12 Intelligence (multi-trait analysis); CRC cis rs875971 0.502 rs2465121 chr7:65621004 A/G cg18876405 chr7:65276391 NA -0.46 -6.27 -0.33 1.13e-9 Aortic root size; CRC cis rs3093024 0.967 rs1571878 chr6:167540842 C/T cg07513332 chr6:167530253 CCR6 -0.32 -5.6 -0.3 4.41e-8 Rheumatoid arthritis; CRC cis rs6693567 0.565 rs832621 chr1:150392909 G/C cg15654264 chr1:150340011 RPRD2 0.39 5.98 0.31 5.74e-9 Migraine; CRC cis rs2346177 0.554 rs34854267 chr2:46708542 T/C cg26688816 chr2:46740690 ATP6V1E2 -0.62 -9.43 -0.46 7.61e-19 HDL cholesterol; CRC cis rs4853012 0.838 rs4452177 chr2:74345206 A/G cg01017244 chr2:74357527 NA 0.68 9.48 0.46 5.09e-19 Gestational age at birth (maternal effect); CRC cis rs3118233 1 rs3118233 chr16:68733646 G/C cg02972257 chr16:68554789 NA 0.45 5.68 0.3 2.95e-8 Red cell distribution width; CRC cis rs9399137 0.507 rs13064 chr6:135287533 A/G cg24558204 chr6:135376177 HBS1L 0.59 8.63 0.43 2.6e-16 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; CRC trans rs2243480 1.000 rs73150014 chr7:65450919 A/C cg10756647 chr7:56101905 PSPH 0.69 7.49 0.38 6.37e-13 Diabetic kidney disease; CRC trans rs9354308 0.840 rs17508021 chr6:66569748 G/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.48 6.06 0.32 3.69e-9 Metabolite levels; CRC cis rs1862618 0.671 rs2591968 chr5:56233541 A/G cg12311346 chr5:56204834 C5orf35 -0.69 -10.31 -0.49 8.63e-22 Initial pursuit acceleration; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg13659026 chr2:85788631 GGCX 0.39 6.3 0.33 9.57e-10 Intelligence (multi-trait analysis); CRC cis rs13108904 0.935 rs13148614 chr4:1248357 G/C cg21620606 chr4:1342894 KIAA1530 0.37 6.4 0.33 5.42e-10 Obesity-related traits; CRC trans rs4332037 0.508 rs60238952 chr7:1914350 A/G cg11693508 chr17:37793320 STARD3 0.62 8.39 0.42 1.48e-15 Bipolar disorder; CRC trans rs12940923 1.000 rs34770605 chr17:56376206 C/T cg16900910 chr15:72789182 ARIH1 0.53 6.04 0.32 4.19e-9 Circulating myeloperoxidase levels (plasma); CRC cis rs116095464 0.510 rs7714944 chr5:231765 C/T cg22496380 chr5:211416 CCDC127 -0.85 -9.74 -0.47 7.39e-20 Breast cancer; CRC cis rs7671266 0.668 rs6834055 chr4:10158511 A/T cg00071950 chr4:10020882 SLC2A9 -0.49 -6.25 -0.33 1.25e-9 Cardiovascular disease risk factors; CRC cis rs7811142 0.943 rs111493473 chr7:100049742 A/G cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.77 10.99 0.52 3.91e-24 Platelet count; CRC cis rs7412746 0.658 rs11582281 chr1:150826831 T/C cg17724175 chr1:150552817 MCL1 0.49 7.14 0.37 5.93e-12 Melanoma; CRC cis rs9648716 1.000 rs986050 chr7:140490928 C/A cg10747023 chr7:140774559 NA 0.44 5.67 0.3 3.1e-8 Type 2 diabetes; CRC cis rs478304 0.654 rs11601509 chr11:65456864 T/C cg05805236 chr11:65401703 PCNXL3 -0.41 -6.57 -0.34 1.93e-10 Acne (severe); CRC cis rs6764363 0.587 rs7646675 chr3:276273 C/T cg02057681 chr3:285234 CHL1 0.43 7.19 0.37 4.31e-12 Sudden cardiac arrest; CRC trans rs1005277 0.579 rs2749612 chr10:38488610 G/A cg11292332 chr7:45801988 SEPT13 -0.38 -6.86 -0.35 3.49e-11 Extrinsic epigenetic age acceleration; CRC cis rs72634258 0.842 rs4908727 chr1:8163122 C/T cg00042356 chr1:8021962 PARK7 0.52 5.94 0.31 7.41e-9 Inflammatory bowel disease; CRC cis rs853679 0.517 rs9380060 chr6:28132603 G/A cg25164649 chr6:28176230 NA 0.78 9.66 0.47 1.33e-19 Depression; CRC cis rs6840360 0.615 rs12641438 chr4:152607586 A/G cg09659197 chr4:152720779 NA 0.4 7.97 0.4 2.62e-14 Intelligence (multi-trait analysis); CRC cis rs637571 0.510 rs12575663 chr11:65574535 G/A cg04055107 chr11:65626734 MUS81;CFL1 -0.42 -6.01 -0.31 4.95e-9 Eosinophil percentage of white cells; CRC cis rs7762018 1.000 rs6941766 chr6:170131653 A/G cg24289452 chr6:170231220 NA -0.59 -6.6 -0.34 1.63e-10 Thiazide-induced adverse metabolic effects in hypertensive patients; CRC cis rs9911578 1.000 rs8079774 chr17:56908188 A/G cg12560992 chr17:57184187 TRIM37 0.91 16.64 0.68 1.56e-45 Intelligence (multi-trait analysis); CRC cis rs1707322 0.964 rs7512395 chr1:46361177 G/A cg06784218 chr1:46089804 CCDC17 0.59 10.59 0.5 9.48e-23 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs3126085 1.000 rs3126095 chr1:152309683 G/A cg09127314 chr1:152161683 NA -0.45 -5.61 -0.3 4.29e-8 Atopic dermatitis; CRC cis rs6499255 0.951 rs10500551 chr16:69666970 C/T cg04110750 chr16:69646130 NFAT5 -0.52 -7.11 -0.36 7.26e-12 IgE levels; CRC cis rs262150 0.788 rs2657408 chr7:158782275 A/G cg19418458 chr7:158789849 NA -0.49 -8.47 -0.42 8.44e-16 Facial morphology (factor 20); CRC trans rs1997103 1.000 rs6977292 chr7:55396335 T/C cg20935933 chr6:143382018 AIG1 0.53 6.78 0.35 5.42e-11 QRS interval (sulfonylurea treatment interaction); CRC cis rs35110281 0.687 rs4819284 chr21:45084548 C/T cg04455712 chr21:45112962 RRP1B 0.38 7.35 0.38 1.57e-12 Mean corpuscular volume; CRC cis rs9902453 0.967 rs61240589 chr17:28449035 G/T cg26525008 chr17:28256777 EFCAB5;SSH2 0.55 8.37 0.42 1.7e-15 Coffee consumption (cups per day); CRC cis rs561341 1.000 rs7214017 chr17:30332220 T/C cg19193384 chr17:30244184 NA -0.53 -6.65 -0.34 1.19e-10 Hip circumference adjusted for BMI; CRC cis rs425277 0.585 rs3107156 chr1:2060630 T/C cg04315214 chr1:2043799 PRKCZ 0.54 9.37 0.46 1.16e-18 Height; CRC cis rs13315871 1.000 rs71311865 chr3:58372423 G/A cg20936604 chr3:58311152 NA -0.73 -6.69 -0.35 9.48e-11 Cholesterol, total; CRC cis rs7412746 0.611 rs752376 chr1:150941381 C/T cg15448220 chr1:150897856 SETDB1 0.47 6.88 0.35 3.09e-11 Melanoma; CRC cis rs1519814 0.740 rs4348544 chr8:121044090 T/C cg22335954 chr8:121166405 COL14A1 -0.51 -5.78 -0.3 1.72e-8 Breast cancer; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg26957012 chr11:65305575 SCYL1 -0.35 -5.96 -0.31 6.52e-9 Liver disease severity in Alagille syndrome; CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg06110578 chr6:43597079 MAD2L1BP;GTPBP2 -0.55 -6.46 -0.34 3.82e-10 Diisocyanate-induced asthma; CRC cis rs763014 0.932 rs2269559 chr16:682297 T/C cg07343612 chr16:622815 PIGQ -0.79 -12.9 -0.58 4.41e-31 Height; CRC cis rs758324 0.812 rs13174462 chr5:131217988 A/G cg25547332 chr5:131281432 NA 0.35 5.61 0.3 4.4e-8 Alzheimer's disease in APOE e4- carriers; CRC cis rs938554 0.513 rs4529048 chr4:9997112 G/T cg00071950 chr4:10020882 SLC2A9 0.43 6.85 0.35 3.59e-11 Blood metabolite levels; CRC cis rs7584330 0.780 rs7582828 chr2:238378476 A/C cg16989719 chr2:238392110 NA 0.46 9.28 0.46 2.4e-18 Prostate cancer; CRC cis rs7580658 0.963 rs12052483 chr2:128136820 T/G cg09760422 chr2:128146352 NA -0.36 -6.9 -0.36 2.6e-11 Protein C levels; CRC cis rs10140922 0.931 rs4982262 chr14:35822193 C/T cg07166546 chr14:35805898 NA -0.3 -5.89 -0.31 9.79e-9 Hip circumference adjusted for BMI; CRC cis rs4689388 0.853 rs4293850 chr4:6292020 A/C cg14416269 chr4:6271139 WFS1 0.36 5.92 0.31 8.06e-9 Type 2 diabetes and other traits;Type 2 diabetes; CRC trans rs1814175 0.817 rs1319547 chr11:49916705 C/T cg21153622 chr11:89784906 NA -0.38 -6.05 -0.32 3.99e-9 Height; CRC cis rs897984 0.568 rs4889653 chr16:30895713 C/T cg02466173 chr16:30829666 NA 0.7 9.16 0.45 5.53e-18 Dementia with Lewy bodies; CRC cis rs1448094 0.512 rs61930862 chr12:86246567 A/G cg19622623 chr12:86230825 RASSF9 -0.41 -6.76 -0.35 6.45e-11 Major depressive disorder; CRC cis rs2952156 0.920 rs2934953 chr17:37832315 T/A cg11212589 chr17:38028394 ZPBP2 0.33 5.63 0.3 3.8e-8 Asthma; CRC cis rs7216064 1.000 rs2052187 chr17:65834737 T/C cg12091567 chr17:66097778 LOC651250 -0.63 -7.9 -0.4 4.33e-14 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CRC cis rs6502050 0.734 rs9674631 chr17:80096525 A/G cg09264619 chr17:80180166 NA -0.35 -5.8 -0.3 1.59e-8 Life satisfaction; CRC cis rs1862618 0.853 rs1559282 chr5:56099375 T/A cg18230493 chr5:56204884 C5orf35 -0.7 -9.11 -0.45 8.53e-18 Initial pursuit acceleration; CRC cis rs9309473 0.583 rs35885918 chr2:73612234 T/C cg20560298 chr2:73613845 ALMS1 -0.53 -7.53 -0.38 4.94e-13 Metabolite levels; CRC cis rs6424115 1.000 rs2179395 chr1:24148365 T/C cg10978503 chr1:24200527 CNR2 0.51 8.82 0.44 6.58e-17 Immature fraction of reticulocytes; CRC cis rs6582630 0.502 rs11181230 chr12:38300085 A/G cg26384229 chr12:38710491 ALG10B 0.69 9.74 0.47 7.18e-20 Drug-induced liver injury (flucloxacillin); CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg07970400 chr15:40650285 DISP2 0.37 6.02 0.31 4.65e-9 Obesity-related traits; CRC cis rs6424115 0.830 rs4649124 chr1:24201357 A/G cg10978503 chr1:24200527 CNR2 0.61 11.06 0.52 2.22e-24 Immature fraction of reticulocytes; CRC cis rs208520 0.770 rs2153941 chr6:66885521 A/T cg07460842 chr6:66804631 NA -0.93 -12.55 -0.57 8.48e-30 Exhaled nitric oxide output; CRC cis rs6502050 0.835 rs3935128 chr17:80113414 T/C cg19223190 chr17:80058835 NA 0.4 6.36 0.33 6.88e-10 Life satisfaction; CRC cis rs1707322 1.000 rs785484 chr1:46574015 T/C cg03146154 chr1:46216737 IPP -0.6 -8.01 -0.4 2.03e-14 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs9902453 0.900 rs56195309 chr17:28453753 G/A cg26525008 chr17:28256777 EFCAB5;SSH2 0.56 8.48 0.42 7.52e-16 Coffee consumption (cups per day); CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg09284707 chr11:107799080 RAB39 -0.33 -6.17 -0.32 1.96e-9 Myopia (pathological); CRC cis rs13256369 1.000 rs883648 chr8:8569521 A/G cg06671706 chr8:8559999 CLDN23 0.62 9.28 0.46 2.37e-18 Obesity-related traits; CRC cis rs4700695 1.000 rs4700695 chr5:65411710 G/T cg21114390 chr5:65439923 SFRS12 -0.62 -6.67 -0.35 1.05e-10 Facial morphology (factor 19); CRC cis rs3793683 0.520 rs12769959 chr10:134579026 A/C cg18305652 chr10:134549665 INPP5A 0.52 7.15 0.37 5.58e-12 Migraine; CRC cis rs78456975 1.000 rs4073861 chr2:1563611 G/A cg01028140 chr2:1542097 TPO -0.56 -5.79 -0.3 1.65e-8 Placebo response in major depressive disorder (% change in symptom score); CRC cis rs2153535 0.580 rs915352 chr6:8442766 G/A cg07606381 chr6:8435919 SLC35B3 0.68 10.86 0.51 1.08e-23 Motion sickness; CRC cis rs6448317 0.954 rs7666033 chr4:24925272 A/G cg21108841 chr4:24914750 CCDC149 -0.43 -5.63 -0.3 3.85e-8 Heschl's gyrus morphology; CRC cis rs798554 0.679 rs2644300 chr7:2883071 G/A cg13628971 chr7:2884303 GNA12 0.58 8.13 0.41 8.73e-15 Height; CRC cis rs2153535 0.584 rs62395677 chr6:8371589 G/A cg21535247 chr6:8435926 SLC35B3 -0.41 -6.0 -0.31 5.22e-9 Motion sickness; CRC cis rs6860806 0.661 rs2136188 chr5:131577514 A/G cg09877947 chr5:131593287 PDLIM4 -0.47 -8.88 -0.44 4.27e-17 Breast cancer; CRC cis rs6901250 0.851 rs168128 chr6:117166865 A/G cg12892004 chr6:117198278 RFX6 -0.43 -6.67 -0.35 1.07e-10 C-reactive protein levels; CRC cis rs9297145 0.565 rs6952161 chr7:98733337 A/G cg05967295 chr7:98741636 SMURF1 0.63 9.91 0.48 2.03e-20 Crohn's disease;Inflammatory bowel disease;Ulcerative colitis; CRC cis rs2457480 0.866 rs10160170 chr10:44692843 A/G cg09554077 chr10:44749378 NA 0.48 5.8 0.3 1.54e-8 Coronary artery disease; CRC cis rs7647973 0.961 rs4955430 chr3:49378088 G/A cg07636037 chr3:49044803 WDR6 0.59 7.08 0.36 8.54e-12 Menarche (age at onset); CRC cis rs6740322 0.895 rs6710656 chr2:43566941 C/T cg06169590 chr2:43455088 ZFP36L2;LOC100129726 -0.64 -7.78 -0.39 9.48e-14 Coronary artery disease; CRC cis rs6964587 1.000 rs58965837 chr7:91585258 T/A cg17063962 chr7:91808500 NA 0.8 13.98 0.61 3.38e-35 Breast cancer; CRC cis rs2952156 0.920 rs907090 chr17:37833632 T/C cg11212589 chr17:38028394 ZPBP2 0.35 6.15 0.32 2.26e-9 Asthma; CRC cis rs11098499 0.863 rs6853998 chr4:120475860 C/A cg24375607 chr4:120327624 NA 0.48 7.24 0.37 3.2e-12 Corneal astigmatism; CRC cis rs2204008 0.694 rs1672436 chr12:38132547 G/T cg26384229 chr12:38710491 ALG10B -0.55 -8.21 -0.41 5.21e-15 Bladder cancer; CRC trans rs9693857 0.520 rs13267391 chr8:9356714 C/T cg06636001 chr8:8085503 FLJ10661 0.47 6.25 0.33 1.27e-9 Systolic blood pressure; CRC trans rs4653663 0.599 rs4653665 chr1:225941904 T/G cg08367804 chr16:3639160 BTBD12 -0.34 -5.97 -0.31 6.02e-9 Neuroticism; CRC cis rs10782582 0.609 rs78776851 chr1:76424845 T/C cg10523679 chr1:76189770 ACADM -0.43 -6.01 -0.31 4.97e-9 Daytime sleep phenotypes; CRC cis rs3789045 1.000 rs11588857 chr1:204587047 G/A cg17419461 chr1:204415978 PIK3C2B -0.49 -6.94 -0.36 2.05e-11 Educational attainment (college completion); CRC cis rs10927875 0.541 rs1048245 chr1:16341354 T/G cg22431228 chr1:16359049 CLCNKA -0.37 -6.64 -0.34 1.29e-10 Dilated cardiomyopathy; CRC cis rs1904096 0.506 rs6823404 chr4:95197520 C/T cg11021082 chr4:95130006 SMARCAD1 -0.58 -9.24 -0.45 3.14e-18 Type 2 diabetes; CRC cis rs9517320 0.967 rs2274056 chr13:99134839 G/C cg07423050 chr13:99094983 FARP1 0.38 6.04 0.32 4.19e-9 Longevity; CRC cis rs995000 0.965 rs12116574 chr1:63037837 C/T cg19896129 chr1:63156450 NA 0.39 5.72 0.3 2.39e-8 Triglyceride levels; CRC cis rs6479527 0.773 rs10739967 chr9:96757117 A/G cg14459158 chr9:96720562 NA 0.41 7.41 0.38 1.09e-12 Esophageal adenocarcinoma; CRC trans rs11039798 0.925 rs7482967 chr11:48613527 T/A cg03929089 chr4:120376271 NA 0.63 6.33 0.33 8.23e-10 Axial length; CRC cis rs8031584 0.678 rs4779497 chr15:31151365 T/A cg08704250 chr15:31115839 NA -0.56 -9.86 -0.48 2.86e-20 Huntington's disease progression; CRC cis rs11608355 0.545 rs33997929 chr12:109912064 C/T cg05360138 chr12:110035743 NA 0.78 8.76 0.43 1.07e-16 Neuroticism; CRC cis rs6951245 0.872 rs75398423 chr7:1098414 T/G cg24642844 chr7:1081250 C7orf50 -0.76 -9.16 -0.45 5.78e-18 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs427941 0.703 rs201446 chr7:101738323 C/G cg06246474 chr7:101738831 CUX1 0.46 7.16 0.37 5.46e-12 Plasma omega-3 polyunsaturated fatty acid level (eicosapentaenoic acid); CRC cis rs2404602 0.735 rs11857327 chr15:76764263 G/C cg23625390 chr15:77176239 SCAPER -0.84 -12.73 -0.57 1.79e-30 Blood metabolite levels; CRC trans rs2303319 0.504 rs12467625 chr2:162603387 C/A cg12500891 chr11:57225987 NA -0.65 -6.06 -0.32 3.77e-9 Cognitive function; CRC cis rs3768617 0.591 rs9787073 chr1:182974328 T/C ch.1.3577855R chr1:183094577 LAMC1 0.69 10.55 0.5 1.28e-22 Fuchs's corneal dystrophy; CRC trans rs10242455 0.702 rs73713580 chr7:99241610 C/T cg09045935 chr12:6379348 NA 0.92 6.84 0.35 3.8e-11 Blood metabolite levels; CRC cis rs6499255 0.951 rs56316408 chr16:69658776 A/G cg04110750 chr16:69646130 NFAT5 -0.56 -7.62 -0.39 2.73e-13 IgE levels; CRC cis rs2230307 0.656 rs644835 chr1:100543962 A/G cg24955406 chr1:100503596 HIAT1 0.59 6.09 0.32 3.11e-9 Carotid intima media thickness; CRC cis rs2204008 0.744 rs2222344 chr12:38406832 T/G cg13010199 chr12:38710504 ALG10B 0.47 6.4 0.33 5.43e-10 Bladder cancer; CRC cis rs72717009 0.825 rs7552317 chr1:161479438 C/T cg15358701 chr1:161410459 NA -0.6 -6.44 -0.33 4.35e-10 Rheumatoid arthritis; CRC cis rs3733585 0.699 rs7663079 chr4:9966771 T/C cg11266682 chr4:10021025 SLC2A9 -0.46 -9.35 -0.46 1.35e-18 Cleft plate (environmental tobacco smoke interaction); CRC cis rs17270561 0.609 rs9358876 chr6:25738956 A/G cg16482183 chr6:26056742 HIST1H1C 0.83 10.58 0.5 1.07e-22 Iron status biomarkers; CRC trans rs10411161 0.702 rs7251929 chr19:52389258 C/T cg22319618 chr22:45562946 NUP50 -0.62 -6.51 -0.34 2.78e-10 Breast cancer; CRC cis rs28386778 0.897 rs2665831 chr17:61912392 C/T cg06601766 chr17:61851465 DDX42;CCDC47 0.45 6.02 0.31 4.75e-9 Prudent dietary pattern; CRC cis rs7172809 0.643 rs61483316 chr15:77834147 C/T cg10437265 chr15:77819839 NA -0.37 -5.99 -0.31 5.45e-9 Glucose homeostasis traits; CRC cis rs1552244 0.515 rs67626468 chr3:10161518 C/A cg13047869 chr3:10149882 C3orf24 0.53 6.47 0.34 3.57e-10 Alzheimer's disease; CRC cis rs4319547 0.585 rs10846792 chr12:122882374 T/C cg23029597 chr12:123009494 RSRC2 -0.56 -6.93 -0.36 2.21e-11 Body mass index; CRC trans rs7267979 0.899 rs2179459 chr20:25456141 C/A cg17903999 chr18:56338584 MALT1 -0.4 -6.55 -0.34 2.22e-10 Liver enzyme levels (alkaline phosphatase); CRC trans rs853679 0.546 rs175597 chr6:27810626 T/C cg06606381 chr12:133084897 FBRSL1 -0.76 -6.57 -0.34 1.91e-10 Depression; CRC cis rs9733 0.818 rs12130363 chr1:150688596 T/C cg17724175 chr1:150552817 MCL1 -0.46 -7.28 -0.37 2.55e-12 Tonsillectomy; CRC cis rs2108622 0.727 rs62107764 chr19:15982658 A/G cg13772218 chr19:15982569 NA 0.49 7.01 0.36 1.39e-11 Circulating phylloquinone levels;Vitamin E levels;Acenocoumarol maintenance dosage;Response to Vitamin E supplementation;Metabolite levels;Warfarin maintenance dose; CRC cis rs1395 0.744 rs11126935 chr2:27476740 G/T cg14242246 chr2:27434262 C2orf28;SLC5A6 0.32 6.21 0.32 1.55e-9 Blood metabolite levels; CRC cis rs13256369 0.950 rs12548792 chr8:8568031 T/C cg06671706 chr8:8559999 CLDN23 0.61 8.92 0.44 3.25e-17 Obesity-related traits; CRC cis rs7666738 0.830 rs13144771 chr4:99026935 G/C cg17366294 chr4:99064904 C4orf37 0.44 7.48 0.38 6.96e-13 Colonoscopy-negative controls vs population controls; CRC cis rs11148252 0.740 rs9596648 chr13:52934569 A/T cg00495681 chr13:53174319 NA -0.56 -8.23 -0.41 4.54e-15 Lewy body disease; CRC cis rs6502050 0.835 rs10163483 chr17:80110396 C/A cg09264619 chr17:80180166 NA -0.34 -5.81 -0.3 1.5e-8 Life satisfaction; CRC cis rs1865760 0.602 rs2157050 chr6:26020431 C/T cg17691542 chr6:26056736 HIST1H1C 0.56 8.7 0.43 1.63e-16 Height; CRC cis rs769267 1.000 rs2074090 chr19:19449686 G/T cg03709012 chr19:19516395 GATAD2A -0.67 -10.29 -0.49 1.03e-21 Tonsillectomy; CRC cis rs9660992 0.674 rs72745221 chr1:205262337 G/A cg21643547 chr1:205240462 TMCC2 -0.44 -7.06 -0.36 1.01e-11 Mean corpuscular volume;Mean platelet volume; CRC cis rs6662572 0.703 rs6689417 chr1:46388008 C/T cg03123370 chr1:45965343 CCDC163P;MMACHC -0.45 -5.76 -0.3 1.98e-8 Blood protein levels; CRC cis rs896854 0.715 rs12548874 chr8:95935164 A/C cg13393036 chr8:95962371 TP53INP1 0.52 8.59 0.43 3.45e-16 Type 2 diabetes; CRC cis rs892961 0.899 rs7222532 chr17:75413302 G/C cg05865280 chr17:75406074 SEPT9 0.63 14.51 0.62 3.27e-37 Airflow obstruction; CRC cis rs9910055 0.683 rs7220138 chr17:42254011 C/G cg09913183 chr17:42254507 C17orf65;ASB16 0.65 10.18 0.49 2.4e-21 Total body bone mineral density; CRC cis rs7666738 0.830 rs11097606 chr4:99011486 C/T cg05340658 chr4:99064831 C4orf37 0.62 9.63 0.47 1.71e-19 Colonoscopy-negative controls vs population controls; CRC cis rs2239547 0.522 rs9831409 chr3:52985711 A/T cg11645453 chr3:52864694 ITIH4 -0.51 -9.67 -0.47 1.21e-19 Schizophrenia; CRC trans rs629535 0.699 rs539956 chr8:70033647 G/A cg21567404 chr3:27674614 NA 0.95 16.08 0.66 2.35e-43 Dupuytren's disease; CRC cis rs9549328 0.614 rs35872678 chr13:113617231 A/T cg20742385 chr13:113633654 MCF2L 0.56 9.52 0.46 3.92e-19 Systolic blood pressure; CRC cis rs10256972 0.967 rs1881122 chr7:1040946 A/T cg03923535 chr7:1197113 ZFAND2A 0.41 5.65 0.3 3.53e-8 Longevity;Endometriosis; CRC trans rs9329221 0.650 rs657913 chr8:9882575 G/T cg16141378 chr3:129829833 LOC729375 0.42 6.24 0.33 1.35e-9 Neuroticism; CRC cis rs1005277 0.579 rs2472175 chr10:38382901 T/G cg25427524 chr10:38739819 LOC399744 -0.77 -13.64 -0.6 6.68e-34 Extrinsic epigenetic age acceleration; CRC cis rs7772486 0.805 rs4896831 chr6:145959481 T/C cg23711669 chr6:146136114 FBXO30 0.66 11.0 0.52 3.6e-24 Lobe attachment (rater-scored or self-reported); CRC cis rs6963495 0.745 rs2392749 chr7:105182605 A/G cg02135003 chr7:105160482 PUS7 -0.67 -10.2 -0.49 2.07e-21 Bipolar disorder (body mass index interaction); CRC cis rs3018066 0.867 rs6852388 chr4:107011960 G/T cg01869342 chr4:106983673 TBCK 0.37 5.69 0.3 2.79e-8 Cancer; CRC cis rs2882667 0.690 rs288014 chr5:138195793 A/G cg09476006 chr5:138032270 NA -0.55 -9.83 -0.48 3.65e-20 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs853679 0.882 rs9468300 chr6:28126840 C/T cg03623178 chr6:28175578 NA 0.83 6.72 0.35 7.91e-11 Depression; CRC cis rs10911232 0.507 rs7547953 chr1:183031641 T/G ch.1.3577855R chr1:183094577 LAMC1 0.83 14.36 0.62 1.26e-36 Hypertriglyceridemia; CRC trans rs66573146 1.000 rs6838042 chr4:6973049 G/T cg07817883 chr1:32538562 TMEM39B 1.56 13.2 0.59 3.14e-32 Granulocyte percentage of myeloid white cells; CRC cis rs7503807 0.515 rs869190 chr17:78668593 G/T cg00549398 chr17:78725201 RPTOR 0.43 5.7 0.3 2.62e-8 Obesity; CRC cis rs2075371 0.933 rs1868785 chr7:133945855 G/C cg11752832 chr7:134001865 SLC35B4 0.42 6.35 0.33 6.97e-10 Mean platelet volume; CRC cis rs7705042 0.828 rs249677 chr5:141539339 C/A cg07392085 chr5:141489673 NDFIP1 0.43 6.75 0.35 6.75e-11 Asthma; CRC cis rs6912958 0.703 rs9353483 chr6:88097180 G/A cg04972856 chr6:88032051 C6orf162;GJB7 0.33 6.19 0.32 1.79e-9 Monocyte percentage of white cells; CRC cis rs7712401 0.755 rs6595407 chr5:122100398 C/T cg18764291 chr5:122110994 SNX2 0.41 6.46 0.34 3.7e-10 Mean platelet volume; CRC cis rs2067615 0.579 rs66716938 chr12:107196825 T/C cg13491945 chr12:107078410 RFX4 0.34 5.92 0.31 7.9e-9 Heart rate; CRC cis rs9303280 0.806 rs11870965 chr17:38030205 T/A cg20243544 chr17:37824526 PNMT 0.37 5.69 0.3 2.82e-8 Self-reported allergy; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg06056004 chr5:44809616 MRPS30 0.43 6.15 0.32 2.19e-9 Response to antipsychotic treatment; CRC cis rs798554 0.757 rs1182188 chr7:2869985 T/C cg19717773 chr7:2847554 GNA12 -0.47 -6.81 -0.35 4.68e-11 Height; CRC cis rs713587 0.967 rs6749422 chr2:25150011 C/G cg22495460 chr2:25135724 ADCY3 -0.78 -14.01 -0.61 2.67e-35 Body mass index in non-asthmatics; CRC cis rs10242455 0.571 rs41279866 chr7:99315276 C/T cg18809830 chr7:99032528 PTCD1 -1.05 -7.59 -0.39 3.23e-13 Blood metabolite levels; CRC cis rs7089973 0.604 rs7897937 chr10:116591318 A/G cg23260525 chr10:116636907 FAM160B1 0.35 8.07 0.41 1.34e-14 Bipolar disorder or attention deficit hyperactivity disorder; CRC trans rs7267979 0.932 rs1985737 chr20:25591468 T/A cg17903999 chr18:56338584 MALT1 -0.41 -6.81 -0.35 4.65e-11 Liver enzyme levels (alkaline phosphatase); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg00004979 chr12:111885466 SH2B3 -0.38 -6.17 -0.32 2.01e-9 Liver disease severity in Alagille syndrome; CRC cis rs6479527 0.840 rs987511 chr9:96757868 C/T cg14459158 chr9:96720562 NA 0.42 7.62 0.39 2.69e-13 Esophageal adenocarcinoma; CRC cis rs11212617 0.967 rs11605442 chr11:108077857 G/A cg01991180 chr11:108092276 ATM;NPAT 0.44 6.62 0.34 1.44e-10 Response to metformin in type 2 diabetes (glycemic); CRC cis rs1215050 0.791 rs13114823 chr4:98671119 G/A cg05340658 chr4:99064831 C4orf37 -0.46 -6.96 -0.36 1.89e-11 Waist-to-hip ratio adjusted for body mass index; CRC cis rs6582630 0.519 rs10880194 chr12:38302836 G/A cg13010199 chr12:38710504 ALG10B 0.47 6.29 0.33 1.01e-9 Drug-induced liver injury (flucloxacillin); CRC cis rs1707322 0.896 rs785518 chr1:46568422 A/T cg03146154 chr1:46216737 IPP -0.52 -7.18 -0.37 4.54e-12 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs6942756 0.876 rs2303303 chr7:129019736 G/A cg02491457 chr7:128862824 NA -0.61 -8.29 -0.42 2.95e-15 White matter hyperintensity burden; CRC cis rs6724607 1.000 rs6434402 chr2:191469322 C/T cg10560079 chr2:191398806 TMEM194B -0.49 -7.07 -0.36 9.19e-12 Pulse pressure; CRC trans rs1814175 0.817 rs6486046 chr11:49997017 T/C cg15704280 chr7:45808275 SEPT13 -0.96 -18.4 -0.71 1.8e-52 Height; CRC cis rs1178968 0.901 rs1178958 chr7:72777384 G/A cg25889504 chr7:72793014 NA 0.54 6.12 0.32 2.63e-9 Triglyceride levels; CRC cis rs736801 0.740 rs17622378 chr5:131778452 A/G cg00255919 chr5:131827918 IRF1 -0.35 -6.04 -0.32 4.22e-9 Breast cancer;Mosquito bite size; CRC cis rs868943 0.714 rs13216178 chr6:116392629 T/G cg15226275 chr6:116381976 FRK 0.3 7.25 0.37 3e-12 Total cholesterol levels; CRC cis rs4629180 0.675 rs6742474 chr2:102091075 G/A cg01388757 chr2:102091195 RFX8 -0.35 -5.81 -0.3 1.5e-8 Chronic rhinosinusitis with nasal polyps; CRC cis rs7762018 0.505 rs79843499 chr6:170068420 A/G cg19338460 chr6:170058176 WDR27 -1.21 -11.41 -0.53 1.29e-25 Thiazide-induced adverse metabolic effects in hypertensive patients; CRC trans rs7829975 0.714 rs60315134 chr8:8670599 A/G cg16141378 chr3:129829833 LOC729375 -0.42 -6.17 -0.32 2.04e-9 Mood instability; CRC cis rs78456975 0.622 rs11896517 chr2:1518112 A/G cg12573674 chr2:1569213 NA -0.65 -7.65 -0.39 2.24e-13 Placebo response in major depressive disorder (% change in symptom score); CRC cis rs938554 0.612 rs13113918 chr4:9998493 A/G cg11266682 chr4:10021025 SLC2A9 0.4 6.45 0.34 3.98e-10 Blood metabolite levels; CRC cis rs12594515 1.000 rs6493176 chr15:45990026 A/G cg19682013 chr15:45996608 NA 0.32 6.7 0.35 9.09e-11 Waist circumference;Weight; CRC trans rs6550704 0.687 rs9865314 chr3:22634337 A/G cg12439463 chr17:79848761 ANAPC11;THOC4 -0.41 -6.05 -0.32 4.05e-9 Daytime sleep phenotypes; CRC cis rs1862618 0.853 rs252922 chr5:56136343 G/T cg12311346 chr5:56204834 C5orf35 -0.79 -10.49 -0.5 2.05e-22 Initial pursuit acceleration; CRC cis rs1005277 0.602 rs1780141 chr10:38504299 T/C cg25517755 chr10:38738941 LOC399744 -0.4 -5.91 -0.31 8.75e-9 Extrinsic epigenetic age acceleration; CRC cis rs704795 0.902 rs11887784 chr2:27679919 A/G cg02592271 chr2:27665507 KRTCAP3 -0.27 -6.04 -0.32 4.06e-9 Menopause (age at onset); CRC cis rs12791968 0.659 rs12808379 chr11:45009273 C/G cg11846598 chr11:44996168 LOC221122 -0.6 -9.02 -0.45 1.57e-17 Inhibitory control; CRC cis rs7605827 0.930 rs4668903 chr2:15530051 C/G cg19274914 chr2:15703543 NA 0.39 5.88 0.31 9.87e-9 Educational attainment (years of education); CRC cis rs12500482 0.509 rs1203784 chr4:2427108 T/C cg26605046 chr4:2439731 NA -0.42 -6.49 -0.34 3.18e-10 Cognitive function; CRC cis rs40363 0.857 rs55989968 chr16:3530658 C/G cg21433313 chr16:3507492 NAT15 0.76 8.49 0.42 7.17e-16 Tuberculosis; CRC cis rs7615952 0.576 rs12497295 chr3:125818650 G/A cg06494592 chr3:125709126 NA -0.57 -6.78 -0.35 5.71e-11 Blood pressure (smoking interaction); CRC cis rs317689 0.718 rs160827 chr12:69770147 G/A cg14784868 chr12:69753453 YEATS4 0.57 7.0 0.36 1.43e-11 Response to diuretic therapy; CRC cis rs7786808 0.505 rs67537656 chr7:158192646 C/T cg17401720 chr7:158221031 PTPRN2 -0.41 -6.7 -0.35 9.01e-11 Obesity-related traits; CRC cis rs6061231 0.624 rs8668 chr20:60964064 C/T cg22633769 chr20:60982531 CABLES2 -0.46 -6.93 -0.36 2.18e-11 Colorectal cancer; CRC cis rs3796352 1.000 rs35507120 chr3:53053924 C/T cg06204229 chr3:52865917 ITIH4 0.49 5.68 0.3 2.95e-8 Immune reponse to smallpox (secreted IL-2); CRC cis rs12134245 0.776 rs12124682 chr1:91995542 A/G cg21854759 chr1:92012499 NA -0.53 -8.76 -0.43 1.05e-16 Breast cancer; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg17270843 chr10:99079074 FRAT1 -0.33 -6.48 -0.34 3.28e-10 Myopia (pathological); CRC cis rs6570726 0.935 rs406343 chr6:145874388 A/G cg05347473 chr6:146136440 FBXO30 0.39 6.14 0.32 2.31e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs76878669 0.561 rs1892940 chr11:66111251 A/G cg18002602 chr11:66138449 SLC29A2 -0.27 -5.9 -0.31 9.13e-9 Educational attainment (years of education); CRC cis rs7666738 1.000 rs1426673 chr4:98924024 G/A cg03676636 chr4:99064102 C4orf37 0.22 6.19 0.32 1.83e-9 Colonoscopy-negative controls vs population controls; CRC cis rs4237845 0.611 rs9971722 chr12:58308383 G/T cg02175503 chr12:58329896 NA 0.78 12.36 0.56 4.24e-29 Intelligence (multi-trait analysis); CRC cis rs1799949 0.965 rs11656945 chr17:41330265 A/G cg25072359 chr17:41440525 NA 0.43 6.36 0.33 6.77e-10 Menopause (age at onset); CRC cis rs7312933 0.585 rs7969814 chr12:42669657 C/G cg19980929 chr12:42632907 YAF2 0.45 6.87 0.35 3.17e-11 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CRC cis rs6545883 0.929 rs2592352 chr2:61665336 C/T cg15711740 chr2:61764176 XPO1 -0.45 -6.02 -0.31 4.77e-9 Tuberculosis; CRC trans rs7647973 0.710 rs7629322 chr3:49621994 C/T cg21665057 chr3:196295764 WDR53;FBXO45 -0.71 -7.9 -0.4 4.16e-14 Menarche (age at onset); CRC cis rs17095355 1.000 rs12263915 chr10:111744664 G/C cg00817464 chr10:111662876 XPNPEP1 -0.63 -8.57 -0.43 3.99e-16 Biliary atresia; CRC cis rs6598955 0.671 rs11247905 chr1:26627907 G/C cg04990556 chr1:26633338 UBXN11 0.52 5.68 0.3 3.04e-8 Obesity-related traits; CRC cis rs2521295 1.000 rs2521295 chr11:2348860 T/A cg09785033 chr11:2336066 TSPAN32 -0.53 -6.24 -0.33 1.36e-9 Monocyte count; CRC cis rs8180040 0.701 rs11130111 chr3:47009805 C/T cg27129171 chr3:47204927 SETD2 0.65 10.29 0.49 1.04e-21 Colorectal cancer; CRC cis rs7772486 0.658 rs4895683 chr6:146113654 T/A cg23711669 chr6:146136114 FBXO30 -0.69 -11.58 -0.54 3.12e-26 Lobe attachment (rater-scored or self-reported); CRC trans rs875971 0.545 rs73142233 chr7:65686280 T/A cg02869306 chr7:64672164 INTS4L1 -0.42 -6.12 -0.32 2.59e-9 Aortic root size; CRC trans rs2727020 0.563 rs10769582 chr11:49474040 T/C cg11707556 chr5:10655725 ANKRD33B -0.39 -7.43 -0.38 9.74e-13 Coronary artery disease; CRC trans rs6951245 1.000 rs28528096 chr7:1070912 G/C cg13565492 chr6:43139072 SRF -0.71 -7.31 -0.37 2.04e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs427941 0.632 rs201507 chr7:101764141 T/C cg06246474 chr7:101738831 CUX1 0.44 6.81 0.35 4.77e-11 Plasma omega-3 polyunsaturated fatty acid level (eicosapentaenoic acid); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg18069125 chr20:45439836 NA -0.3 -5.98 -0.31 5.74e-9 Liver disease severity in Alagille syndrome; CRC cis rs6582630 0.519 rs11182021 chr12:38443709 A/T cg13010199 chr12:38710504 ALG10B -0.46 -6.63 -0.34 1.37e-10 Drug-induced liver injury (flucloxacillin); CRC cis rs6123683 0.752 rs6070035 chr20:55825693 A/G cg13236649 chr20:55835020 BMP7 0.43 6.78 0.35 5.64e-11 Facial morphology (factor 5, width of mouth relative to central midface); CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg08635118 chr7:6144369 USP42 0.45 6.14 0.32 2.39e-9 Anxiety disorder; CRC cis rs11031096 0.727 rs7940013 chr11:4138304 C/T cg18678763 chr11:4115507 RRM1 -0.42 -7.17 -0.37 4.91e-12 Mean corpuscular volume;Mean corpuscular hemoglobin; CRC cis rs2479724 0.870 rs6902650 chr6:41764080 G/A cg17623882 chr6:41773611 USP49 0.55 9.13 0.45 7.17e-18 Menarche (age at onset); CRC cis rs10256972 0.591 rs11766651 chr7:1161646 A/G cg03923535 chr7:1197113 ZFAND2A 0.68 9.98 0.48 1.2e-20 Longevity;Endometriosis; CRC cis rs7552404 1.000 rs28602663 chr1:76235355 C/T cg10523679 chr1:76189770 ACADM 0.82 11.35 0.53 2.12e-25 Blood metabolite levels;Acylcarnitine levels; CRC cis rs9902453 0.765 rs2259857 chr17:28097780 C/T cg26525008 chr17:28256777 EFCAB5;SSH2 -0.73 -12.18 -0.56 1.98e-28 Coffee consumption (cups per day); CRC cis rs775227 0.574 rs60279293 chr3:113096087 T/G cg18753928 chr3:113234510 CCDC52 -0.55 -6.71 -0.35 8.75e-11 Dental caries; CRC cis rs6964587 1.000 rs6970277 chr7:91680655 T/C cg17063962 chr7:91808500 NA 0.77 12.28 0.56 8.8e-29 Breast cancer; CRC cis rs478304 0.934 rs12801731 chr11:65549606 T/C cg08755490 chr11:65554678 OVOL1 0.4 5.79 0.3 1.66e-8 Acne (severe); CRC cis rs1401999 1.000 rs1401999 chr3:183678342 C/G cg05044414 chr3:183734942 ABCC5 0.48 8.34 0.42 2.1e-15 Anterior chamber depth; CRC cis rs13108904 0.539 rs13145722 chr4:1338422 T/A cg15763984 chr4:1342303 KIAA1530 0.44 6.9 0.36 2.74e-11 Obesity-related traits; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg00067102 chr1:241803367 OPN3 0.44 6.39 0.33 5.6e-10 Intelligence (multi-trait analysis); CRC cis rs7607369 0.648 rs7559490 chr2:219656867 A/T cg02176678 chr2:219576539 TTLL4 -0.56 -8.96 -0.44 2.44e-17 Red blood cell count;Amyotrophic lateral sclerosis; CRC cis rs4663866 1.000 rs6734408 chr2:239137481 A/C cg16914508 chr2:239161102 PER2 0.73 7.85 0.4 5.82e-14 Irritable bowel syndrome; CRC cis rs7089973 0.836 rs1966384 chr10:116627910 G/T cg23260525 chr10:116636907 FAM160B1 0.32 6.85 0.35 3.73e-11 Bipolar disorder or attention deficit hyperactivity disorder; CRC cis rs17209837 0.646 rs4148818 chr7:87083738 T/C cg00919237 chr7:87102261 ABCB4 -0.54 -7.18 -0.37 4.66e-12 Gallbladder cancer; CRC trans rs2727020 0.595 rs7924311 chr11:49507573 G/A cg15704280 chr7:45808275 SEPT13 -0.95 -18.41 -0.71 1.64e-52 Coronary artery disease; CRC cis rs6502050 0.835 rs3088177 chr17:80111724 A/G cg25804541 chr17:80189381 SLC16A3 -0.3 -5.83 -0.31 1.36e-8 Life satisfaction; CRC cis rs6694672 1.000 rs1759009 chr1:197026672 C/T cg13682187 chr1:196946512 CFHR5 -0.46 -7.78 -0.39 9.67e-14 Asthma; CRC cis rs2380220 0.872 rs7750757 chr6:95997118 A/G cg15832292 chr6:96025679 MANEA 0.59 6.08 0.32 3.41e-9 Behavioural disinhibition (generation interaction); CRC cis rs2354432 0.607 rs9661159 chr1:146757923 G/A cg25205988 chr1:146714368 CHD1L -1.23 -9.95 -0.48 1.45e-20 Mitochondrial DNA levels; CRC cis rs1475911 1.000 rs55645900 chr21:43515728 G/T cg19766460 chr21:43528205 UMODL1;C21orf128 0.64 7.3 0.37 2.2e-12 IgG glycosylation; CRC cis rs951366 0.789 rs823130 chr1:205714372 C/T cg24503407 chr1:205819492 PM20D1 0.82 12.47 0.57 1.73e-29 Menarche (age at onset); CRC cis rs10504229 1.000 rs66731170 chr8:58187895 C/G cg05313129 chr8:58192883 C8orf71 -0.47 -6.99 -0.36 1.49e-11 Developmental language disorder (linguistic errors); CRC cis rs9914988 0.725 rs9905510 chr17:27092325 G/A cg20469991 chr17:27169893 C17orf63 -0.6 -7.26 -0.37 2.76e-12 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs4474465 0.646 rs10751297 chr11:78278567 C/T cg27205649 chr11:78285834 NARS2 0.53 6.88 0.35 3.02e-11 Alzheimer's disease (survival time); CRC cis rs2732480 0.500 rs2450989 chr12:48653408 A/G cg24011408 chr12:48396354 COL2A1 -0.45 -6.33 -0.33 8.01e-10 Hemoglobin concentration;Red blood cell count;Hematocrit; CRC cis rs3751196 0.901 rs12422615 chr12:104184884 A/G cg02344784 chr12:104178138 NT5DC3 0.68 7.26 0.37 2.79e-12 Sense of smell; CRC cis rs644799 1.000 rs534497 chr11:95562868 C/G cg25478527 chr11:95522999 CEP57;FAM76B 0.52 7.86 0.4 5.6e-14 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs875971 0.545 rs1909508 chr7:65766353 G/T cg18876405 chr7:65276391 NA 0.44 6.18 0.32 1.89e-9 Aortic root size; CRC cis rs16975963 0.843 rs73041045 chr19:38296026 C/T cg15135657 chr19:38346511 NA -0.44 -5.94 -0.31 7.12e-9 Longevity; CRC cis rs651907 0.535 rs11714444 chr3:101513682 G/A cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.59 7.86 0.4 5.42e-14 Colorectal cancer; CRC trans rs1814175 0.867 rs7926002 chr11:49616018 A/G cg11707556 chr5:10655725 ANKRD33B -0.42 -7.83 -0.4 6.87e-14 Height; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg06510711 chr12:123849672 NA 0.48 6.05 0.32 3.96e-9 Thyroid stimulating hormone; CRC trans rs951252 0.504 rs11734405 chr4:146081096 C/T cg06930513 chr13:20623578 ZMYM2 0.47 6.22 0.32 1.52e-9 Hip circumference; CRC cis rs7412746 0.611 rs2280627 chr1:150935872 A/G cg15448220 chr1:150897856 SETDB1 0.48 7.02 0.36 1.3e-11 Melanoma; CRC cis rs7772486 0.875 rs10457794 chr6:146415608 A/G cg23711669 chr6:146136114 FBXO30 0.66 11.56 0.54 3.54e-26 Lobe attachment (rater-scored or self-reported); CRC cis rs10463316 0.894 rs12652733 chr5:150753999 G/A cg03212797 chr5:150827313 SLC36A1 -0.5 -7.92 -0.4 3.7e-14 Metabolite levels (Pyroglutamine); CRC cis rs3106136 0.814 rs6839224 chr4:95279214 A/C cg11021082 chr4:95130006 SMARCAD1 0.36 5.63 0.3 3.84e-8 Capecitabine sensitivity; CRC cis rs514406 0.861 rs554760 chr1:53266749 G/A cg25767906 chr1:53392781 SCP2 0.47 7.49 0.38 6.24e-13 Monocyte count; CRC cis rs7917772 0.636 rs2486757 chr10:104535145 C/T cg22532475 chr10:104410764 TRIM8 -0.34 -5.82 -0.31 1.43e-8 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC cis rs7727544 0.709 rs272852 chr5:131688767 G/A cg24060327 chr5:131705240 SLC22A5 -0.4 -6.48 -0.34 3.36e-10 Blood metabolite levels; CRC trans rs10983614 1.000 rs7867776 chr9:120072627 A/G cg11381792 chr21:45432451 TRAPPC10 0.49 6.94 0.36 2.08e-11 Survival in pancreatic cancer; CRC cis rs9326248 0.817 rs6589598 chr11:117002403 A/G cg26566898 chr11:117069891 TAGLN 0.42 8.1 0.41 1.05e-14 Blood protein levels; CRC cis rs947211 1.000 rs947211 chr1:205752665 A/G cg07167872 chr1:205819463 PM20D1 0.41 5.78 0.3 1.74e-8 Parkinson's disease; CRC cis rs8060686 0.641 rs76419201 chr16:68153553 G/A cg08314208 chr16:67682810 RLTPR -0.58 -6.23 -0.32 1.47e-9 HDL cholesterol;Metabolic syndrome; CRC cis rs4713118 0.869 rs9461405 chr6:27719375 G/T cg20933634 chr6:27740509 NA 0.57 8.5 0.42 6.56e-16 Parkinson's disease; CRC cis rs116979167 0.514 rs1706915 chr7:105196437 A/G cg02135003 chr7:105160482 PUS7 -0.52 -8.07 -0.41 1.32e-14 Bipolar disorder (body mass index interaction); CRC cis rs644799 1.000 rs680134 chr11:95559517 T/C cg25478527 chr11:95522999 CEP57;FAM76B 0.52 7.86 0.4 5.55e-14 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs72829446 0.530 rs9646411 chr17:7398909 A/G cg07168214 chr17:7380112 ZBTB4 0.39 5.91 0.31 8.66e-9 Androgen levels; CRC cis rs9969804 1.000 rs9969804 chr9:95429120 A/C cg14631576 chr9:95140430 CENPP -0.31 -5.74 -0.3 2.18e-8 Height; CRC cis rs17767392 0.813 rs11848785 chr14:72057355 G/A cg13720639 chr14:72061746 SIPA1L1 0.5 6.34 0.33 7.64e-10 Mitral valve prolapse; CRC cis rs875971 0.862 rs57866200 chr7:65565392 A/G cg12463550 chr7:65579703 CRCP -0.53 -7.55 -0.38 4.32e-13 Aortic root size; CRC cis rs863345 0.604 rs1873511 chr1:158461366 C/T cg12129480 chr1:158549410 OR10X1 -0.29 -6.04 -0.32 4.2e-9 Pneumococcal bacteremia; CRC trans rs6601450 0.522 rs7837979 chr8:10198534 C/T cg06636001 chr8:8085503 FLJ10661 0.46 7.07 0.36 9.38e-12 Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC cis rs11098499 0.738 rs10026493 chr4:120384194 C/G cg24375607 chr4:120327624 NA 0.5 7.72 0.39 1.4e-13 Corneal astigmatism; CRC cis rs7726839 0.507 rs60068988 chr5:597668 T/C cg09021430 chr5:549028 NA -0.72 -8.29 -0.42 2.99e-15 Obesity-related traits; CRC trans rs9630182 0.540 rs11022834 chr11:13479364 T/C cg13741668 chr9:85679694 NA 0.37 5.97 0.31 6.12e-9 Bone mineral density; CRC cis rs9311474 0.713 rs352165 chr3:52242902 A/G cg08222913 chr3:52553049 STAB1 -0.38 -7.12 -0.37 6.74e-12 Electroencephalogram traits; CRC cis rs6714710 0.603 rs7583868 chr2:98588372 C/A cg26665480 chr2:98280029 ACTR1B 0.53 7.34 0.38 1.68e-12 Posterior cortical atrophy and Alzheimer's disease; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg15604425 chr10:103825102 HPS6 0.49 6.98 0.36 1.62e-11 Response to antipsychotic treatment; CRC cis rs7044106 0.537 rs10739573 chr9:123489818 A/G cg14255062 chr9:123606675 PSMD5;LOC253039 0.45 5.86 0.31 1.1e-8 Hip circumference adjusted for BMI; CRC cis rs9527 0.615 rs7096452 chr10:104736563 G/A cg15744005 chr10:104629667 AS3MT -0.3 -6.1 -0.32 2.93e-9 Arsenic metabolism; CRC trans rs7647973 0.626 rs1996664 chr3:49878395 A/G cg21665057 chr3:196295764 WDR53;FBXO45 0.64 7.04 0.36 1.15e-11 Menarche (age at onset); CRC cis rs7191439 0.728 rs8043637 chr16:88781125 T/C cg27087555 chr16:88793112 FAM38A -1.36 -13.12 -0.59 6.59e-32 Plateletcrit; CRC cis rs10791323 0.517 rs1120245 chr11:133745290 A/G cg15485101 chr11:133734466 NA 0.39 7.16 0.37 5.37e-12 Childhood ear infection; CRC cis rs875971 0.658 rs432667 chr7:65514633 A/G cg18912574 chr7:65842487 NCRNA00174 0.38 6.49 0.34 3.1e-10 Aortic root size; CRC cis rs6714710 0.603 rs34373359 chr2:98442202 G/A cg26665480 chr2:98280029 ACTR1B 0.53 7.27 0.37 2.59e-12 Posterior cortical atrophy and Alzheimer's disease; CRC cis rs3804749 0.966 rs920900 chr3:122845671 C/G cg26084141 chr3:122786895 PDIA5 -0.22 -5.77 -0.3 1.81e-8 Plateletcrit;Mean platelet volume;Platelet count;Platelet distribution width; CRC cis rs2346177 1.000 rs12619985 chr2:46641627 T/C cg26688816 chr2:46740690 ATP6V1E2 -0.51 -7.94 -0.4 3.3e-14 HDL cholesterol; CRC cis rs559928 0.593 rs112275221 chr11:63936994 C/T cg19465662 chr11:63993652 NUDT22;TRPT1 0.68 6.38 0.33 6.16e-10 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; CRC cis rs3020333 0.755 rs851996 chr6:152016803 C/T cg22157087 chr6:152012887 ESR1 0.5 7.58 0.39 3.54e-13 Total body bone mineral density; CRC cis rs6860806 0.507 rs270601 chr5:131656997 T/C cg18301423 chr5:131593218 PDLIM4 0.39 6.42 0.33 4.87e-10 Breast cancer; CRC cis rs2985684 0.894 rs10147029 chr14:50020232 G/T cg04989706 chr14:50066350 PPIL5 0.57 8.23 0.41 4.44e-15 Carotid intima media thickness; CRC cis rs7666738 0.830 rs7657490 chr4:99043973 C/T cg05340658 chr4:99064831 C4orf37 0.6 9.35 0.46 1.36e-18 Colonoscopy-negative controls vs population controls; CRC trans rs5756813 0.661 rs5995500 chr22:38204640 A/G cg19894588 chr14:64061835 NA -0.62 -8.41 -0.42 1.3e-15 Optic cup area;Vertical cup-disc ratio; CRC cis rs7762018 1.000 rs7747645 chr6:170070291 G/C cg24289452 chr6:170231220 NA -0.57 -6.21 -0.32 1.6e-9 Thiazide-induced adverse metabolic effects in hypertensive patients; CRC cis rs2836974 0.863 rs1065242 chr21:40567716 C/G cg11890956 chr21:40555474 PSMG1 1.09 18.67 0.72 1.44e-53 Cognitive function; CRC cis rs7659604 1.000 rs6814995 chr4:122664963 A/T cg06713675 chr4:122721982 EXOSC9 0.4 6.48 0.34 3.27e-10 Type 2 diabetes; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg16076804 chr14:45366412 C14orf28 0.44 6.23 0.32 1.42e-9 Response to antipsychotic treatment; CRC cis rs1198872 0.558 rs10929699 chr2:10918209 C/T cg15705551 chr2:10952987 PDIA6 0.43 5.9 0.31 9.09e-9 Cardiac Troponin-T levels; CRC cis rs1552244 1.000 rs67569278 chr3:10149893 T/C cg10729496 chr3:10149963 C3orf24 0.54 6.87 0.35 3.26e-11 Alzheimer's disease; CRC cis rs6831352 0.879 rs56295995 chr4:100060899 C/T cg12011299 chr4:100065546 ADH4 -0.5 -9.53 -0.47 3.62e-19 Alcohol dependence; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg08187779 chr8:102217898 ZNF706 -0.41 -6.39 -0.33 5.62e-10 Myopia (pathological); CRC cis rs4604732 0.631 rs74154672 chr1:247625625 C/G cg12758973 chr1:247694275 LOC148824;OR2C3 0.42 6.14 0.32 2.32e-9 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CRC trans rs9858542 0.953 rs6446264 chr3:49417243 C/A cg21582582 chr3:182698605 DCUN1D1 -0.52 -6.66 -0.34 1.12e-10 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC trans rs208520 0.954 rs12190073 chr6:66983740 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.88 10.79 0.51 1.94e-23 Exhaled nitric oxide output; CRC cis rs8177253 0.606 rs6787177 chr3:133450720 C/T cg24879335 chr3:133465180 TF 0.37 6.92 0.36 2.42e-11 Iron status biomarkers; CRC cis rs9467711 0.606 rs13190739 chr6:26587373 G/T cg12315302 chr6:26189340 HIST1H4D 0.99 6.93 0.36 2.22e-11 Autism spectrum disorder or schizophrenia; CRC cis rs4654899 1.000 rs72865329 chr1:21517567 G/A cg02927042 chr1:21476669 EIF4G3 -0.47 -7.43 -0.38 9.2e-13 Superior frontal gyrus grey matter volume; CRC cis rs116095464 0.558 rs7356535 chr5:284117 G/T cg22857025 chr5:266934 NA -1.16 -12.06 -0.55 5.57e-28 Breast cancer; CRC cis rs10791097 0.667 rs1893019 chr11:130756664 C/G cg12179176 chr11:130786555 SNX19 0.75 12.45 0.57 2e-29 Autism spectrum disorder or schizophrenia;Schizophrenia; CRC cis rs67478160 0.619 rs2368560 chr14:104273311 C/T cg08213375 chr14:104286397 PPP1R13B 0.64 13.22 0.59 2.82e-32 Schizophrenia; CRC cis rs35110281 0.837 rs7279958 chr21:45016016 C/A cg01579765 chr21:45077557 HSF2BP -0.37 -7.18 -0.37 4.65e-12 Mean corpuscular volume; CRC cis rs9916302 0.904 rs801420 chr17:37466103 C/G cg00129232 chr17:37814104 STARD3 0.55 8.26 0.41 3.49e-15 Glomerular filtration rate (creatinine); CRC cis rs7614311 0.636 rs73130576 chr3:63890875 T/C cg22134162 chr3:63841271 THOC7 -0.58 -5.86 -0.31 1.11e-8 Lung function (FVC);Lung function (FEV1); CRC cis rs4285028 0.948 rs12493408 chr3:121692119 C/A cg11130432 chr3:121712080 ILDR1 -0.52 -6.76 -0.35 6.37e-11 Multiple sclerosis; CRC cis rs4713118 0.869 rs6922574 chr6:27693003 A/T cg03623178 chr6:28175578 NA 0.65 8.93 0.44 3.16e-17 Parkinson's disease; CRC cis rs7119 0.717 rs34981488 chr15:77723403 T/G cg05673287 chr15:77411982 SGK269 -0.56 -8.61 -0.43 3.13e-16 Type 2 diabetes; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg15635336 chr19:4182521 SIRT6;ANKRD24 0.4 6.18 0.32 1.86e-9 Liver disease severity in Alagille syndrome; CRC cis rs7191439 0.790 rs2306046 chr16:88781419 A/G cg27087555 chr16:88793112 FAM38A -1.36 -13.12 -0.59 6.59e-32 Plateletcrit; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg01083650 chr1:202858430 RABIF 0.5 6.88 0.35 3.05e-11 Response to antipsychotic treatment; CRC trans rs804280 0.509 rs13268030 chr8:11783073 C/T cg06636001 chr8:8085503 FLJ10661 0.47 7.22 0.37 3.57e-12 Myopia (pathological); CRC trans rs875971 0.660 rs2191268 chr7:66110224 C/T cg02442412 chr4:83720054 SCD5 -0.4 -6.46 -0.34 3.88e-10 Aortic root size; CRC cis rs1577917 1.000 rs12199784 chr6:86726808 C/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.53 -6.9 -0.36 2.63e-11 Response to antipsychotic treatment; CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg10729317 chr20:2821390 FAM113A;VPS16 0.4 6.49 0.34 3.11e-10 Obesity-related traits; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg03031933 chr8:145598519 ADCK5 0.42 7.38 0.38 1.33e-12 Liver disease severity in Alagille syndrome; CRC cis rs40363 0.645 rs1690446 chr16:3519009 T/C cg22508957 chr16:3507546 NAT15 0.65 9.92 0.48 1.82e-20 Tuberculosis; CRC cis rs4713118 0.662 rs156744 chr6:27967274 G/A cg15786705 chr6:28176104 NA 0.68 9.73 0.47 8.1e-20 Parkinson's disease; CRC cis rs8062405 0.755 rs17707300 chr16:28593347 A/G cg05139728 chr16:28306816 SBK1 -0.37 -5.93 -0.31 7.65e-9 Cognitive ability (multi-trait analysis);Cognitive ability; CRC cis rs10256972 0.521 rs7457418 chr7:1110255 C/T cg18402987 chr7:1209562 NA 0.42 6.25 0.33 1.29e-9 Longevity;Endometriosis; CRC cis rs11645898 0.765 rs112439757 chr16:72168337 C/T cg14768367 chr16:72042858 DHODH -0.52 -6.1 -0.32 3.03e-9 Blood protein levels; CRC cis rs881375 0.967 rs1860824 chr9:123659339 G/T cg14255062 chr9:123606675 PSMD5;LOC253039 0.42 6.06 0.32 3.63e-9 Rheumatoid arthritis; CRC cis rs1153858 1.000 rs7164602 chr15:45671325 A/G cg10760299 chr15:45669010 GATM 0.5 7.82 0.4 7.18e-14 Homoarginine levels; CRC cis rs56114371 0.530 rs169262 chr6:27770890 C/T cg12172441 chr6:28176163 NA 0.48 5.69 0.3 2.81e-8 Breast cancer; CRC cis rs9296092 0.560 rs9469506 chr6:33527897 A/G cg13560919 chr6:33536144 NA -0.44 -6.28 -0.33 1.09e-9 Age at smoking initiation in chronic obstructive pulmonary disease; CRC cis rs11608355 0.515 rs1045263 chr12:109974191 A/G cg05360138 chr12:110035743 NA 0.75 8.52 0.43 5.81e-16 Neuroticism; CRC cis rs853679 0.699 rs9468318 chr6:28209531 T/A cg25164649 chr6:28176230 NA 0.55 5.75 0.3 2e-8 Depression; CRC cis rs7215564 0.908 rs7501497 chr17:78660738 T/C cg09596252 chr17:78655493 RPTOR 0.54 5.73 0.3 2.25e-8 Myopia (pathological); CRC cis rs10751667 0.666 rs7936830 chr11:959686 A/G cg06064525 chr11:970664 AP2A2 -0.3 -6.21 -0.32 1.58e-9 Alzheimer's disease (late onset); CRC cis rs8177179 0.967 rs10935085 chr3:133459735 C/T cg24879335 chr3:133465180 TF 0.49 9.55 0.47 3.16e-19 Iron status biomarkers (transferrin levels); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg23288521 chr20:37075451 SNORA39;SNHG11 0.45 6.56 0.34 2.06e-10 Response to antipsychotic treatment; CRC cis rs7833790 0.777 rs6473301 chr8:82691340 A/G cg27398817 chr8:82754497 SNX16 -0.48 -5.81 -0.31 1.47e-8 Diastolic blood pressure; CRC cis rs4363385 0.647 rs56158137 chr1:152994380 A/T cg25856811 chr1:152973957 SPRR3 -0.22 -6.01 -0.31 4.96e-9 Inflammatory skin disease; CRC cis rs17767294 0.611 rs66487884 chr6:28202912 C/G cg02683197 chr6:28174875 NA 0.86 8.08 0.41 1.22e-14 Parkinson's disease; CRC cis rs9611565 0.559 rs7290991 chr22:41964361 C/G cg06634786 chr22:41940651 POLR3H -0.51 -5.92 -0.31 8.16e-9 Vitiligo; CRC cis rs2228479 0.850 rs12597296 chr16:89822331 C/T cg06558623 chr16:89946397 TCF25 1.13 10.45 0.5 2.85e-22 Skin colour saturation; CRC cis rs908922 0.676 rs6674451 chr1:152531054 C/T cg09873164 chr1:152488093 CRCT1 0.36 6.16 0.32 2.14e-9 Hair morphology; CRC cis rs367615 0.506 rs2963013 chr5:108775811 C/T cg17395555 chr5:108820864 NA -0.42 -8.13 -0.41 8.87e-15 Colorectal cancer (SNP x SNP interaction); CRC cis rs9921222 0.500 rs8046256 chr16:393948 C/T cg12437481 chr16:420112 MRPL28 -0.84 -11.06 -0.52 2.14e-24 Bone mineral density (spine);Bone mineral density; CRC trans rs11654801 0.812 rs9972887 chr17:20876472 A/G cg23759823 chr7:139672531 TBXAS1 -0.42 -6.35 -0.33 7.07e-10 Mosquito bite size; CRC cis rs35520189 0.591 rs34027384 chr2:113698094 G/A cg12858261 chr2:113808755 IL1F8 0.46 6.1 0.32 3.05e-9 Obstructive sleep apnea trait (apnea hypopnea index); CRC cis rs896854 0.654 rs13278601 chr8:95972974 G/C cg16049864 chr8:95962084 TP53INP1 -0.64 -11.81 -0.55 4.47e-27 Type 2 diabetes; CRC cis rs7119 0.717 rs12901100 chr15:77815558 T/A cg27398640 chr15:77910606 LINGO1 -0.44 -7.53 -0.38 4.81e-13 Type 2 diabetes; CRC cis rs11120822 0.787 rs11120829 chr1:7123793 A/C cg20434152 chr1:7120926 CAMTA1 -0.4 -7.15 -0.37 5.79e-12 Stearic acid (18:0) levels; CRC cis rs9287719 0.601 rs10177062 chr2:10713698 C/T cg00105475 chr2:10696890 NA 0.48 7.3 0.37 2.23e-12 Prostate cancer; CRC cis rs9322193 0.923 rs9800736 chr6:149982417 A/G cg00933542 chr6:150070202 PCMT1 0.32 6.57 0.34 1.93e-10 Lung cancer; CRC cis rs10504229 0.639 rs67002486 chr8:58117218 A/G cg21724239 chr8:58056113 NA 0.49 6.81 0.35 4.75e-11 Developmental language disorder (linguistic errors); CRC cis rs4237845 0.637 rs7299249 chr12:58343710 C/T cg00677455 chr12:58241039 CTDSP2 0.4 5.67 0.3 3.08e-8 Intelligence (multi-trait analysis); CRC cis rs9457247 1.000 rs385113 chr6:167403971 A/G cg23791538 chr6:167370224 RNASET2 -0.38 -5.94 -0.31 7.32e-9 Crohn's disease; CRC cis rs10540 1.000 rs61876342 chr11:496193 T/G cg03934478 chr11:495069 RNH1 0.69 7.73 0.39 1.28e-13 Body mass index; CRC cis rs1401999 1.000 rs2872249 chr3:183636273 T/A cg20387954 chr3:183756860 HTR3D 0.44 7.37 0.38 1.43e-12 Anterior chamber depth; CRC cis rs853679 0.517 rs9468292 chr6:28095355 G/A cg21251018 chr6:28226885 NKAPL 0.48 6.33 0.33 7.86e-10 Depression; CRC cis rs172166 0.561 rs149974 chr6:27985096 T/C cg12273811 chr6:28175739 NA 0.45 6.71 0.35 8.28e-11 Cardiac Troponin-T levels; CRC cis rs11971779 0.938 rs11981688 chr7:139088895 A/G cg07862535 chr7:139043722 LUC7L2 0.93 11.47 0.53 7.55e-26 Diisocyanate-induced asthma; CRC cis rs2032447 0.765 rs1935235 chr6:26067782 C/G cg04800585 chr6:26043546 HIST1H2BB 0.51 7.44 0.38 8.99e-13 Intelligence (multi-trait analysis); CRC cis rs4474465 1.000 rs11237511 chr11:78173606 C/T cg27205649 chr11:78285834 NARS2 -0.47 -5.95 -0.31 6.95e-9 Alzheimer's disease (survival time); CRC cis rs9925964 0.933 rs9923231 chr16:31107689 C/T cg03418659 chr16:31128414 MYST1 0.47 6.75 0.35 6.72e-11 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs11785693 0.862 rs6994323 chr8:4996786 T/A cg26367366 chr8:4980734 NA 0.79 9.53 0.47 3.55e-19 Neuroticism (multi-trait analysis);Neuroticism; CRC cis rs1448094 0.512 rs1349063 chr12:86264237 C/T cg25456477 chr12:86230367 RASSF9 0.32 5.61 0.3 4.38e-8 Major depressive disorder; CRC cis rs4132509 0.696 rs12023642 chr1:243767826 T/G cg21452805 chr1:244014465 NA 0.56 6.26 0.33 1.22e-9 RR interval (heart rate); CRC cis rs2249694 1.000 rs2480258 chr10:135352100 T/C cg20169779 chr10:135381914 SYCE1 0.54 8.67 0.43 1.93e-16 Obesity-related traits; CRC cis rs2842992 0.747 rs1547093 chr6:160205991 C/A cg19482086 chr6:160211437 TCP1;MRPL18 0.71 9.41 0.46 8.86e-19 Age-related macular degeneration (geographic atrophy); CRC cis rs950169 0.881 rs62029596 chr15:84955434 A/G cg17507749 chr15:85114479 UBE2QP1 0.74 10.59 0.5 9.91e-23 Schizophrenia; CRC cis rs11958404 0.858 rs72818142 chr5:157474934 C/T cg05962755 chr5:157440814 NA 1.0 12.65 0.57 3.79e-30 IgG glycosylation; CRC cis rs6502050 0.835 rs8078795 chr17:80126320 C/T cg02741985 chr17:80059408 CCDC57 0.44 7.3 0.37 2.15e-12 Life satisfaction; CRC cis rs11122272 0.735 rs2749711 chr1:231537543 G/A cg06096015 chr1:231504339 EGLN1 0.4 6.01 0.31 4.81e-9 Hemoglobin concentration; CRC cis rs1018836 0.923 rs12545726 chr8:91532087 T/A cg16814680 chr8:91681699 NA -0.7 -11.14 -0.52 1.15e-24 Ejection fraction in Tripanosoma cruzi seropositivity; CRC cis rs1656402 1.000 rs1656399 chr2:233427803 C/T cg03852847 chr2:233439513 NA 0.43 7.47 0.38 7.25e-13 Non-small cell lung cancer (survival); CRC cis rs9910055 0.529 rs228765 chr17:42186422 C/T cg13607699 chr17:42295918 UBTF -0.46 -6.07 -0.32 3.57e-9 Total body bone mineral density; CRC cis rs10193935 0.792 rs222472 chr2:42662911 C/T cg27598129 chr2:42591480 NA -0.62 -7.66 -0.39 2.12e-13 Colonoscopy-negative controls vs population controls; CRC cis rs10504229 1.000 rs17805332 chr8:58169798 A/G cg02290350 chr8:58132656 NA -0.42 -6.06 -0.32 3.67e-9 Developmental language disorder (linguistic errors); CRC trans rs7937682 0.575 rs1940391 chr11:111776891 G/A cg18187862 chr3:45730750 SACM1L -0.43 -5.99 -0.31 5.56e-9 Primary sclerosing cholangitis; CRC trans rs2303319 0.504 rs56371522 chr2:162491109 G/A cg06896663 chr8:82754093 SNX16 -0.69 -5.98 -0.31 5.75e-9 Cognitive function; CRC cis rs8067545 0.611 rs2703803 chr17:20107069 G/T cg13482628 chr17:19912719 NA -0.46 -7.29 -0.37 2.28e-12 Schizophrenia; CRC cis rs10504073 0.584 rs11786103 chr8:49904077 A/G cg00325661 chr8:49890786 NA 0.61 11.02 0.52 2.99e-24 Blood metabolite ratios; CRC trans rs2243480 1.000 rs34974928 chr7:65364006 T/C cg10756647 chr7:56101905 PSPH 0.73 7.85 0.4 5.73e-14 Diabetic kidney disease; CRC cis rs9322193 0.923 rs9322207 chr6:149978321 G/A cg07701084 chr6:150067640 NUP43 0.55 8.11 0.41 1.01e-14 Lung cancer; CRC cis rs13108904 0.967 rs12642396 chr4:1293055 C/A cg00684032 chr4:1343700 KIAA1530 0.47 6.78 0.35 5.74e-11 Obesity-related traits; CRC cis rs2952156 1.000 rs2952156 chr17:37876835 A/G cg00129232 chr17:37814104 STARD3 -0.66 -10.68 -0.51 4.75e-23 Asthma; CRC cis rs11212617 0.967 rs227040 chr11:108223391 T/C cg12106634 chr11:108092400 ATM;NPAT 0.43 6.41 0.33 5.07e-10 Response to metformin in type 2 diabetes (glycemic); CRC cis rs2880765 0.546 rs11637726 chr15:86059271 C/T cg10818794 chr15:86012489 AKAP13 0.42 6.11 0.32 2.88e-9 Coronary artery disease; CRC cis rs9462027 0.606 rs9462024 chr6:34772793 G/A cg07306190 chr6:34760872 UHRF1BP1 -0.34 -6.04 -0.32 4.26e-9 Systemic lupus erythematosus; CRC cis rs7246657 0.882 rs10412043 chr19:37826626 A/C cg23950597 chr19:37808831 NA -0.47 -5.76 -0.3 1.94e-8 Coronary artery calcification; CRC cis rs1799949 1.000 rs4792981 chr17:41308274 A/G cg25072359 chr17:41440525 NA 0.46 6.96 0.36 1.91e-11 Menopause (age at onset); CRC cis rs7312933 0.618 rs6582390 chr12:42634586 C/T cg11827402 chr12:42719852 PPHLN1;ZCRB1 0.65 9.08 0.45 1.02e-17 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CRC cis rs6088580 0.634 rs6088498 chr20:33020446 A/G cg24642439 chr20:33292090 TP53INP2 0.36 6.03 0.32 4.48e-9 Glomerular filtration rate (creatinine); CRC cis rs875971 0.660 rs1860468 chr7:66107252 T/C cg18876405 chr7:65276391 NA -0.63 -11.27 -0.53 3.95e-25 Aortic root size; CRC cis rs2836974 0.897 rs1984022 chr21:40596085 G/A cg17971929 chr21:40555470 PSMG1 0.82 11.69 0.54 1.24e-26 Cognitive function; CRC cis rs2070488 0.965 rs7640050 chr3:38525864 A/C cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.93 17.24 0.69 6.55e-48 Electrocardiographic conduction measures; CRC cis rs17711722 0.523 rs313812 chr7:65505043 T/C cg00343986 chr7:65444356 GUSB -0.47 -6.89 -0.36 2.79e-11 Calcium levels; CRC trans rs1814175 0.669 rs11040455 chr11:49669829 G/C cg15704280 chr7:45808275 SEPT13 -0.71 -11.4 -0.53 1.3e-25 Height; CRC trans rs885518 0.852 rs7040432 chr9:21776159 T/C cg14925137 chr3:121554019 IQCB1;EAF2 0.54 5.99 0.31 5.37e-9 Lung adenocarcinoma; CRC cis rs10924970 1.000 rs4660145 chr1:235350207 T/C cg26050004 chr1:235667680 B3GALNT2 0.39 5.76 0.3 1.92e-8 Asthma; CRC cis rs7044106 0.708 rs920745 chr9:123429943 T/C cg14255062 chr9:123606675 PSMD5;LOC253039 0.44 6.63 0.34 1.35e-10 Hip circumference adjusted for BMI; CRC cis rs11122272 0.677 rs2808615 chr1:231550171 G/A cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX 0.64 9.93 0.48 1.74e-20 Hemoglobin concentration; CRC cis rs9341808 0.644 rs59371711 chr6:80942027 G/T cg08355045 chr6:80787529 NA -0.36 -6.05 -0.32 4.01e-9 Sitting height ratio; CRC cis rs6496667 0.865 rs7178854 chr15:90884634 G/A cg04176472 chr15:90893244 GABARAPL3 0.59 6.6 0.34 1.6e-10 Rheumatoid arthritis; CRC cis rs6933660 0.745 rs6557138 chr6:151732017 C/T cg14416726 chr6:151773293 C6orf211;RMND1 -0.58 -8.85 -0.44 5.66e-17 Menarche (age at onset); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg17411103 chr17:65241599 HELZ 0.4 6.52 0.34 2.61e-10 Liver disease severity in Alagille syndrome; CRC cis rs1005277 0.528 rs2057228 chr10:38515766 T/C cg25517755 chr10:38738941 LOC399744 -0.41 -5.92 -0.31 8.23e-9 Extrinsic epigenetic age acceleration; CRC cis rs2046867 0.818 rs7637138 chr3:72910886 A/G cg25664220 chr3:72788482 NA -0.45 -6.23 -0.32 1.46e-9 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; CRC trans rs2303319 0.504 rs62189047 chr2:162613314 T/A cg12500891 chr11:57225987 NA -0.65 -6.06 -0.32 3.77e-9 Cognitive function; CRC cis rs2933343 0.679 rs789229 chr3:128602526 C/T cg11901034 chr3:128598214 ACAD9 -0.55 -7.74 -0.39 1.2e-13 IgG glycosylation; CRC cis rs2019137 1.000 rs2019137 chr2:113973632 G/A cg21482265 chr2:113992762 PAX8;LOC440839;LOC654433 -0.47 -6.67 -0.35 1.07e-10 Lymphocyte counts; CRC cis rs12188164 0.686 rs72711370 chr5:421057 A/C cg26850624 chr5:429559 AHRR -0.77 -12.45 -0.57 1.99e-29 Cystic fibrosis severity; CRC cis rs1153858 1.000 rs4775911 chr15:45649787 G/T cg14582100 chr15:45693742 SPATA5L1 -0.29 -5.87 -0.31 1.05e-8 Homoarginine levels; CRC cis rs7617480 0.648 rs14018 chr3:48784270 G/A cg07636037 chr3:49044803 WDR6 0.86 9.51 0.46 4.18e-19 Subjective well-being (multi-trait analysis);Menarche (age at onset); CRC cis rs4917300 0.626 rs28375965 chr8:143103882 A/G cg25363559 chr8:143086065 NA -0.32 -6.14 -0.32 2.42e-9 Amyotrophic lateral sclerosis; CRC cis rs2228479 0.867 rs76885005 chr16:89966668 A/G cg19635926 chr16:89946313 TCF25 0.67 7.06 0.36 9.96e-12 Skin colour saturation; CRC cis rs11148252 0.574 rs7139495 chr13:53283318 A/G cg00495681 chr13:53174319 NA 0.84 15.41 0.65 1.01e-40 Lewy body disease; CRC cis rs3808502 0.605 rs11784572 chr8:11174484 C/G cg08265495 chr8:11212668 TDH -0.34 -5.78 -0.3 1.77e-8 Neuroticism; CRC cis rs7762018 1.000 rs4509126 chr6:170068058 A/G cg24289452 chr6:170231220 NA -0.57 -6.21 -0.32 1.6e-9 Thiazide-induced adverse metabolic effects in hypertensive patients; CRC cis rs28386778 0.863 rs6919 chr17:61909485 A/T cg11494091 chr17:61959527 GH2 -0.6 -10.23 -0.49 1.61e-21 Prudent dietary pattern; CRC cis rs12701220 0.894 rs8591 chr7:1036799 C/T cg00990874 chr7:1149470 C7orf50 -0.56 -6.87 -0.35 3.24e-11 Bronchopulmonary dysplasia; CRC cis rs9359856 0.510 rs17293240 chr6:90396370 C/T cg13799429 chr6:90582589 CASP8AP2 0.76 9.95 0.48 1.4e-20 Bipolar disorder; CRC cis rs1348850 0.768 rs57681892 chr2:178357645 G/C cg02961200 chr2:178257176 LOC100130691;AGPS 0.64 9.3 0.46 2.01e-18 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs6963495 0.818 rs114865717 chr7:105158526 C/T cg13798780 chr7:105162888 PUS7 0.68 8.08 0.41 1.27e-14 Bipolar disorder (body mass index interaction); CRC trans rs12478296 1.000 rs66466023 chr2:243046151 T/G cg18288967 chr1:45987694 PRDX1 0.68 7.43 0.38 9.51e-13 Obesity-related traits; CRC cis rs7216064 0.589 rs8072723 chr17:66056970 T/A cg12091567 chr17:66097778 LOC651250 0.91 13.53 0.6 1.84e-33 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CRC cis rs11212617 0.967 rs172895 chr11:108265876 C/G cg12106634 chr11:108092400 ATM;NPAT 0.43 6.4 0.33 5.26e-10 Response to metformin in type 2 diabetes (glycemic); CRC cis rs6570726 0.738 rs6917199 chr6:145918320 G/A cg13319975 chr6:146136371 FBXO30 -0.45 -6.65 -0.34 1.26e-10 Lobe attachment (rater-scored or self-reported); CRC cis rs11098499 0.691 rs10028773 chr4:120265259 C/G cg24375607 chr4:120327624 NA -0.47 -7.51 -0.38 5.45e-13 Corneal astigmatism; CRC trans rs853679 0.546 rs493161 chr6:27850714 A/T cg12315302 chr6:26189340 HIST1H4D 0.71 6.06 0.32 3.81e-9 Depression; CRC trans rs561341 1.000 rs530209 chr17:30315287 A/G cg27661571 chr11:113659931 NA -0.95 -11.14 -0.52 1.11e-24 Hip circumference adjusted for BMI; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg06798479 chr14:102553207 HSP90AA1 0.44 6.04 0.32 4.21e-9 Anxiety disorder; CRC cis rs2304069 0.526 rs6863283 chr5:149402448 C/A cg12661370 chr5:149340060 SLC26A2 0.44 6.47 0.34 3.64e-10 HIV-1 control; CRC cis rs758324 0.853 rs6882899 chr5:131172467 G/C cg25547332 chr5:131281432 NA 0.38 5.64 0.3 3.67e-8 Alzheimer's disease in APOE e4- carriers; CRC cis rs9916302 0.904 rs9898773 chr17:37532507 C/G cg07936489 chr17:37558343 FBXL20 0.81 12.46 0.57 1.95e-29 Glomerular filtration rate (creatinine); CRC cis rs7772486 0.521 rs9485017 chr6:146023326 C/T cg23711669 chr6:146136114 FBXO30 0.49 7.31 0.37 2.11e-12 Lobe attachment (rater-scored or self-reported); CRC cis rs4731207 0.698 rs11979724 chr7:124451045 G/T cg23710748 chr7:124431027 NA 0.38 6.08 0.32 3.28e-9 Cutaneous malignant melanoma; CRC cis rs9916302 0.904 rs4795355 chr17:37427382 C/T cg07936489 chr17:37558343 FBXL20 -0.79 -11.81 -0.55 4.41e-27 Glomerular filtration rate (creatinine); CRC cis rs1218582 0.741 rs10908446 chr1:154869559 G/A cg16680214 chr1:154839983 KCNN3 -0.46 -9.04 -0.45 1.36e-17 Prostate cancer; CRC cis rs17376456 0.825 rs10057130 chr5:93282557 C/T cg09848695 chr5:92956644 FAM172A;MIR2277 0.67 5.78 0.3 1.76e-8 Diabetic retinopathy; CRC cis rs3812049 0.784 rs3749748 chr5:127350549 C/T cg25462716 chr5:127418816 SLC12A2;FLJ33630 -0.75 -8.9 -0.44 3.82e-17 Lymphocyte counts;Red cell distribution width; CRC cis rs7811142 1.000 rs73161762 chr7:100014846 C/T cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.19 16.82 0.68 3.07e-46 Platelet count; CRC trans rs7615952 0.932 rs13086087 chr3:125646281 A/C cg02007433 chr3:129722099 NA -0.45 -6.14 -0.32 2.35e-9 Blood pressure (smoking interaction); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg02848331 chr11:134094369 NCAPD3;VPS26B 0.46 6.41 0.33 5.05e-10 Response to antipsychotic treatment; CRC cis rs367615 0.731 rs58241713 chr5:108853664 G/A cg17395555 chr5:108820864 NA 0.31 6.04 0.32 4.13e-9 Colorectal cancer (SNP x SNP interaction); CRC cis rs17095355 1.000 rs56273398 chr10:111708183 C/T cg00817464 chr10:111662876 XPNPEP1 -0.59 -7.28 -0.37 2.53e-12 Biliary atresia; CRC cis rs9894429 0.683 rs112612275 chr17:79552604 C/A cg21028142 chr17:79581711 NPLOC4 -0.34 -7.23 -0.37 3.45e-12 Eye color traits; CRC trans rs61931739 0.500 rs7311302 chr12:34557211 T/C cg26384229 chr12:38710491 ALG10B 0.6 8.84 0.44 5.75e-17 Morning vs. evening chronotype; CRC cis rs995000 0.868 rs10889357 chr1:63160282 C/T cg19896129 chr1:63156450 NA 0.4 5.92 0.31 8.23e-9 Triglyceride levels; CRC cis rs9549367 0.774 rs9549696 chr13:113875062 C/T cg18105134 chr13:113819100 PROZ -0.7 -10.44 -0.5 3.04e-22 Platelet distribution width; CRC cis rs3768617 0.510 rs2333621 chr1:183090751 A/G ch.1.3577855R chr1:183094577 LAMC1 0.89 15.86 0.66 1.84e-42 Fuchs's corneal dystrophy; CRC cis rs7786808 0.782 rs7787923 chr7:158227312 A/G cg17401720 chr7:158221031 PTPRN2 0.5 8.99 0.44 1.99e-17 Obesity-related traits; CRC cis rs709400 0.633 rs3783395 chr14:103895020 T/C cg12935359 chr14:103987150 CKB -0.49 -8.02 -0.4 1.91e-14 Body mass index; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg12208283 chr19:19303500 LOC729991-MEF2B;RFXANK;LOC729991 0.45 6.52 0.34 2.68e-10 Intelligence (multi-trait analysis); CRC cis rs11645898 0.872 rs34832584 chr16:72162966 G/T cg14768367 chr16:72042858 DHODH -0.59 -6.58 -0.34 1.84e-10 Blood protein levels; CRC cis rs10782582 0.593 rs11801414 chr1:76124517 G/A cg03433033 chr1:76189801 ACADM -0.42 -6.1 -0.32 2.94e-9 Daytime sleep phenotypes; CRC cis rs9322193 0.923 rs10872650 chr6:150082095 A/G cg13206674 chr6:150067644 NUP43 0.69 10.31 0.49 8.56e-22 Lung cancer; CRC cis rs595982 0.559 rs17206700 chr19:49361255 A/G cg21252483 chr19:49399788 TULP2 -0.39 -6.39 -0.33 5.8e-10 Red cell distribution width; CRC cis rs7811142 0.830 rs28495773 chr7:99943583 A/T cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.18 15.71 0.65 6.77e-42 Platelet count; CRC cis rs9522267 0.535 rs9515451 chr13:112234382 A/G cg14352298 chr13:112236639 NA 0.29 6.67 0.35 1.06e-10 Hepatitis; CRC cis rs7312933 0.865 rs1920687 chr12:42398275 T/C cg11827402 chr12:42719852 PPHLN1;ZCRB1 0.6 7.75 0.39 1.18e-13 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CRC trans rs9329221 0.710 rs11779205 chr8:10260100 C/T cg06636001 chr8:8085503 FLJ10661 0.52 7.7 0.39 1.63e-13 Neuroticism; CRC trans rs1005277 0.579 rs2472178 chr10:38384750 T/C cg23533926 chr12:111358616 MYL2 -0.53 -8.19 -0.41 5.94e-15 Extrinsic epigenetic age acceleration; CRC cis rs1129187 0.755 rs9471988 chr6:42944773 T/C cg05552183 chr6:42928497 GNMT 0.53 8.06 0.41 1.4e-14 Alzheimer's disease in APOE e4+ carriers; CRC cis rs1552244 0.752 rs9867091 chr3:10043429 T/C cg00166722 chr3:10149974 C3orf24 0.58 7.87 0.4 5.06e-14 Alzheimer's disease; CRC cis rs9747201 0.889 rs4789784 chr17:80179213 G/A cg23141183 chr17:80185318 SLC16A3 0.41 5.67 0.3 3.1e-8 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs7085104 0.700 rs10883785 chr10:104603588 A/G cg08772003 chr10:104629869 AS3MT -0.35 -6.12 -0.32 2.71e-9 Immature fraction of reticulocytes;Schizophrenia; CRC cis rs6963495 0.818 rs1721498 chr7:105178819 A/C cg02135003 chr7:105160482 PUS7 0.68 10.23 0.49 1.59e-21 Bipolar disorder (body mass index interaction); CRC trans rs7647973 0.626 rs1996663 chr3:49878264 C/G cg21659725 chr3:3221576 CRBN 0.63 7.15 0.37 5.68e-12 Menarche (age at onset); CRC cis rs17711722 0.727 rs35850374 chr7:65357776 A/G cg02869306 chr7:64672164 INTS4L1 -0.35 -5.86 -0.31 1.1e-8 Calcium levels; CRC cis rs2404602 0.716 rs7169394 chr15:76913274 G/A cg23625390 chr15:77176239 SCAPER 0.48 7.04 0.36 1.14e-11 Blood metabolite levels; CRC cis rs1062746 0.544 rs17770933 chr16:87325729 C/T cg02258303 chr16:87377426 FBXO31 -0.51 -7.32 -0.37 1.95e-12 Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 2 peripheral neuropathy); CRC cis rs17490626 0.568 rs12413523 chr10:71211664 C/G cg12610070 chr10:71211762 TSPAN15 -0.42 -7.59 -0.39 3.32e-13 Thrombosis; CRC cis rs6860806 0.661 rs4705927 chr5:131578608 C/G cg18301423 chr5:131593218 PDLIM4 0.38 7.21 0.37 3.98e-12 Breast cancer; CRC cis rs6540556 0.954 rs643118 chr1:209934841 C/T cg23920097 chr1:209922102 NA -0.51 -6.39 -0.33 5.54e-10 Red blood cell count; CRC cis rs78077440 1.000 rs75239587 chr5:40330302 G/A cg09067459 chr5:40385259 NA -0.54 -5.69 -0.3 2.87e-8 Multiple sclerosis; CRC cis rs4555082 0.834 rs2735816 chr14:105721603 C/G cg18132624 chr14:105716052 BTBD6;BRF1 0.45 7.35 0.38 1.56e-12 Mean platelet volume;Platelet distribution width; CRC cis rs477895 0.713 rs3802933 chr11:63988102 C/T cg01518246 chr11:63870912 FLRT1;MACROD1 0.44 5.86 0.31 1.1e-8 Mean platelet volume; CRC cis rs67478160 0.643 rs11847468 chr14:104220295 G/A cg08213375 chr14:104286397 PPP1R13B 0.65 13.76 0.6 2.47e-34 Schizophrenia; CRC cis rs7072216 0.763 rs733346 chr10:100164325 A/C cg26618903 chr10:100175079 PYROXD2 -0.52 -8.73 -0.43 1.28e-16 Metabolite levels; CRC cis rs7412746 0.658 rs4537557 chr1:150734436 A/G cg17724175 chr1:150552817 MCL1 0.49 7.3 0.37 2.19e-12 Melanoma; CRC cis rs4481887 0.893 rs10888349 chr1:248448625 T/C cg00666640 chr1:248458726 OR2T12 0.55 9.8 0.48 4.77e-20 Common traits (Other); CRC cis rs7635838 0.684 rs2606762 chr3:11343889 G/C cg00170343 chr3:11313890 ATG7 0.48 7.47 0.38 7.15e-13 HDL cholesterol; CRC cis rs4660306 1.000 rs2993259 chr1:46001550 T/C cg03123370 chr1:45965343 CCDC163P;MMACHC -0.55 -7.72 -0.39 1.37e-13 Homocysteine levels; CRC cis rs9325144 0.505 rs826893 chr12:39100536 A/G cg26384229 chr12:38710491 ALG10B -0.57 -8.44 -0.42 9.92e-16 Morning vs. evening chronotype; CRC cis rs7772486 0.754 rs9497419 chr6:146142609 T/C cg23711669 chr6:146136114 FBXO30 0.67 11.15 0.52 1.02e-24 Lobe attachment (rater-scored or self-reported); CRC cis rs7605827 0.930 rs2111455 chr2:15549882 C/T cg19274914 chr2:15703543 NA 0.38 5.66 0.3 3.31e-8 Educational attainment (years of education); CRC cis rs1348850 0.789 rs2197611 chr2:178369036 G/C cg22681709 chr2:178499509 PDE11A -0.37 -6.72 -0.35 8.07e-11 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs12200560 0.505 rs4839848 chr6:97076577 G/A cg06623918 chr6:96969491 KIAA0776 0.52 7.77 0.39 1.02e-13 Coronary heart disease; CRC cis rs28386778 0.897 rs1062790 chr17:61896455 A/G cg06601766 chr17:61851465 DDX42;CCDC47 0.44 5.96 0.31 6.33e-9 Prudent dietary pattern; CRC cis rs7618915 0.547 rs11130314 chr3:52697082 T/C cg10802521 chr3:52805072 NEK4 -0.59 -9.02 -0.45 1.55e-17 Bipolar disorder; CRC cis rs425277 0.606 rs262669 chr1:2082489 A/G cg24578937 chr1:2090814 PRKCZ -0.44 -7.98 -0.4 2.45e-14 Height; CRC cis rs7772486 0.754 rs857881 chr6:145970793 C/A cg13319975 chr6:146136371 FBXO30 0.48 7.02 0.36 1.27e-11 Lobe attachment (rater-scored or self-reported); CRC cis rs10504229 0.683 rs16921843 chr8:58113338 T/C cg21724239 chr8:58056113 NA 0.49 6.77 0.35 5.94e-11 Developmental language disorder (linguistic errors); CRC cis rs1129187 0.935 rs4987173 chr6:42931224 G/A cg03790207 chr6:42947109 PEX6 -0.45 -6.34 -0.33 7.6e-10 Alzheimer's disease in APOE e4+ carriers; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg18104674 chr18:60190218 ZCCHC2 0.49 6.58 0.34 1.88e-10 Anxiety disorder; CRC cis rs12956009 0.583 rs16952069 chr18:44904220 T/A cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.41 6.03 0.32 4.46e-9 Educational attainment (years of education); CRC cis rs875971 0.862 rs709609 chr7:65560561 A/G cg11764359 chr7:65958608 NA -0.58 -8.83 -0.44 6.38e-17 Aortic root size; CRC cis rs13336428 0.730 rs3946124 chr16:1525779 A/G cg04976154 chr16:1532411 NA 0.43 8.26 0.41 3.52e-15 Bone mineral density; CRC cis rs11676348 0.935 rs13007992 chr2:218964051 G/T cg00012203 chr2:219082015 ARPC2 -0.38 -5.77 -0.3 1.84e-8 Ulcerative colitis; CRC cis rs748404 0.631 rs4296223 chr15:43645246 T/C cg02155558 chr15:43621948 ADAL;LCMT2 0.54 7.89 0.4 4.53e-14 Lung cancer; CRC cis rs7208859 0.623 rs56163556 chr17:29101868 G/C cg01831904 chr17:28903510 LRRC37B2 -0.63 -6.45 -0.33 4.07e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs72634258 0.519 rs35267144 chr1:7934258 G/A cg26816564 chr1:7831052 VAMP3 0.72 8.4 0.42 1.38e-15 Inflammatory bowel disease; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg15564972 chr6:79787561 PHIP 0.47 6.37 0.33 6.5e-10 Anxiety disorder; CRC cis rs2075371 1.000 rs2075372 chr7:133984432 C/T cg02659138 chr7:134003124 SLC35B4 0.37 6.41 0.33 5.15e-10 Mean platelet volume; CRC cis rs2797160 0.967 rs2797162 chr6:126011381 G/T cg05901451 chr6:126070800 HEY2 0.4 6.2 0.32 1.65e-9 Endometrial cancer; CRC cis rs4481887 0.504 rs11204611 chr1:248364697 T/C cg00666640 chr1:248458726 OR2T12 0.44 7.07 0.36 9.39e-12 Common traits (Other); CRC cis rs2354432 0.556 rs66501488 chr1:146853992 T/C cg25205988 chr1:146714368 CHD1L -1.26 -10.23 -0.49 1.62e-21 Mitochondrial DNA levels; CRC trans rs9329221 0.868 rs7831557 chr8:10280228 C/T cg06636001 chr8:8085503 FLJ10661 -0.62 -9.81 -0.48 4.27e-20 Neuroticism; CRC cis rs78456975 0.607 rs73909625 chr2:1541934 A/G cg01028140 chr2:1542097 TPO -0.57 -5.85 -0.31 1.21e-8 Placebo response in major depressive disorder (% change in symptom score); CRC cis rs7833986 0.501 rs72653962 chr8:56997505 G/A cg23139584 chr8:56987506 RPS20;SNORD54 0.91 12.39 0.56 3.52e-29 Height; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg09655822 chr6:146136083 FBXO30 0.39 6.41 0.33 4.93e-10 Liver disease severity in Alagille syndrome; CRC cis rs875971 0.545 rs2420456 chr7:65745606 T/G cg11764359 chr7:65958608 NA 0.45 5.75 0.3 1.99e-8 Aortic root size; CRC cis rs13064411 0.735 rs6438157 chr3:113207316 G/T cg10517650 chr3:113235015 CCDC52 -0.41 -7.18 -0.37 4.55e-12 Response to simvastatin treatment (PCSK9 protein level change); CRC cis rs7811142 1.000 rs60257855 chr7:100026780 G/C cg21679810 chr7:100027352 MEPCE;ZCWPW1 1.0 13.69 0.6 4.38e-34 Platelet count; CRC trans rs13046373 0.905 rs4816372 chr21:32077414 A/T cg23641560 chr2:182755044 SSFA2 -0.37 -6.21 -0.32 1.62e-9 HDL cholesterol; CRC cis rs7772486 0.754 rs2328707 chr6:146053498 G/A cg05347473 chr6:146136440 FBXO30 -0.38 -5.81 -0.3 1.51e-8 Lobe attachment (rater-scored or self-reported); CRC cis rs2302190 0.882 rs7221205 chr17:56485799 G/A cg25885038 chr17:56607967 SEPT4 -0.41 -6.54 -0.34 2.3e-10 Vitamin D levels; CRC cis rs4285028 0.699 rs1920298 chr3:121597888 T/C cg20356878 chr3:121714668 ILDR1 -0.48 -6.67 -0.35 1.1e-10 Multiple sclerosis; CRC cis rs7044106 0.791 rs10985001 chr9:123484232 G/A cg14255062 chr9:123606675 PSMD5;LOC253039 0.47 7.08 0.36 8.96e-12 Hip circumference adjusted for BMI; CRC cis rs853679 0.517 rs17711801 chr6:28092307 C/G cg12172441 chr6:28176163 NA 0.62 7.4 0.38 1.17e-12 Depression; CRC cis rs6938 0.662 rs12487 chr15:75136694 A/G cg14664628 chr15:75095509 CSK -0.64 -9.99 -0.48 1.11e-20 Breast cancer; CRC cis rs6964587 1.000 rs2285333 chr7:91667692 T/G cg17063962 chr7:91808500 NA 0.8 14.15 0.62 7.64e-36 Breast cancer; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg20630943 chr20:44563219 PCIF1 0.45 6.14 0.32 2.4e-9 Response to antipsychotic treatment; CRC cis rs11148252 0.740 rs7983971 chr13:52790700 C/T cg12458913 chr13:53173898 NA 0.5 7.38 0.38 1.29e-12 Lewy body disease; CRC cis rs13108904 0.901 rs7668661 chr4:1300172 A/G cg21620606 chr4:1342894 KIAA1530 0.4 7.19 0.37 4.37e-12 Obesity-related traits; CRC cis rs2929278 0.638 rs2016840 chr15:44211868 A/G cg02155558 chr15:43621948 ADAL;LCMT2 -0.44 -6.15 -0.32 2.21e-9 Schizophrenia; CRC cis rs10242455 0.702 rs59240302 chr7:99072991 C/G cg18809830 chr7:99032528 PTCD1 -1.18 -8.59 -0.43 3.66e-16 Blood metabolite levels; CRC cis rs13108904 0.870 rs4974578 chr4:1266072 A/G cg02018176 chr4:1364513 KIAA1530 0.45 7.34 0.38 1.64e-12 Obesity-related traits; CRC cis rs4561483 0.583 rs17236573 chr16:11994655 G/C cg08843971 chr16:11963173 GSPT1 0.5 7.45 0.38 8.14e-13 Testicular germ cell tumor; CRC cis rs1878931 0.555 rs27228 chr16:3431933 C/T cg26668626 chr16:3451006 ZNF174;ZNF434 -0.59 -6.68 -0.35 1.02e-10 Body mass index (adult); CRC cis rs7618915 0.547 rs2268026 chr3:52778347 T/C cg05573699 chr3:52720067 GNL3;PBRM1 -0.47 -6.68 -0.35 1.03e-10 Bipolar disorder; CRC cis rs875971 0.862 rs6945775 chr7:65968974 G/A cg18876405 chr7:65276391 NA 0.5 8.29 0.42 2.85e-15 Aortic root size; CRC cis rs9868809 0.772 rs2286651 chr3:48694147 G/A cg00383909 chr3:49044727 WDR6 0.88 8.83 0.44 6.14e-17 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; CRC cis rs2336384 1.000 rs6672267 chr1:12054911 A/G cg13216073 chr1:12042593 MFN2 0.5 7.24 0.37 3.29e-12 Platelet count; CRC cis rs10504229 0.679 rs17193048 chr8:58055392 G/A cg22535103 chr8:58192502 C8orf71 -0.75 -8.32 -0.42 2.37e-15 Developmental language disorder (linguistic errors); CRC cis rs3741151 1.000 rs75004180 chr11:73024739 A/G cg17517138 chr11:73019481 ARHGEF17 1.11 9.94 0.48 1.58e-20 GIP levels in response to oral glucose tolerance test (120 minutes); CRC cis rs7647973 1.000 rs11719762 chr3:49409002 G/C cg07690219 chr3:49449608 TCTA;RHOA -0.52 -6.18 -0.32 1.9e-9 Menarche (age at onset); CRC cis rs2836950 0.565 rs2150413 chr21:40614878 C/T cg11890956 chr21:40555474 PSMG1 -0.63 -9.2 -0.45 4.32e-18 Menarche (age at onset); CRC cis rs12477438 0.765 rs10193039 chr2:99692373 A/T cg26064155 chr2:99771622 LIPT1;TSGA10 -0.67 -9.21 -0.45 3.99e-18 Chronic sinus infection; CRC cis rs6700896 0.966 rs4655729 chr1:66082471 A/G cg04111102 chr1:66153794 NA 0.35 6.21 0.32 1.56e-9 C-reactive protein;Mean corpuscular volume;Mean corpuscular hemoglobin; CRC cis rs9814567 1.000 rs1498718 chr3:134205920 A/G cg06541857 chr3:134203789 ANAPC13;CEP63 -0.38 -5.72 -0.3 2.36e-8 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs4862750 0.832 rs10007858 chr4:187877492 A/G cg27532560 chr4:187881888 NA -0.55 -10.08 -0.49 5.4e-21 Lobe attachment (rater-scored or self-reported); CRC cis rs4713675 0.546 rs3818521 chr6:33657246 C/T cg14003231 chr6:33640908 ITPR3 0.55 8.75 0.43 1.16e-16 Plateletcrit; CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg14059817 chr7:64466808 NA 0.38 6.02 0.31 4.54e-9 Obesity-related traits; CRC cis rs10504229 0.728 rs17804624 chr8:58154216 T/C cg11062466 chr8:58055876 NA 0.45 6.11 0.32 2.74e-9 Developmental language disorder (linguistic errors); CRC cis rs7937682 0.889 rs1789361 chr11:111485334 T/C cg19812747 chr11:111475976 SIK2 -0.57 -9.75 -0.47 7e-20 Primary sclerosing cholangitis; CRC cis rs10791097 0.694 rs7940027 chr11:130745591 A/G cg12179176 chr11:130786555 SNX19 0.75 12.66 0.57 3.46e-30 Autism spectrum disorder or schizophrenia;Schizophrenia; CRC cis rs6499255 1.000 rs6499253 chr16:69802672 C/T cg04110750 chr16:69646130 NFAT5 -0.52 -7.0 -0.36 1.46e-11 IgE levels; CRC cis rs4654899 0.601 rs6668094 chr1:21464387 C/T cg02927042 chr1:21476669 EIF4G3 0.37 5.96 0.31 6.48e-9 Superior frontal gyrus grey matter volume; CRC cis rs796364 1.000 rs281759 chr2:200787719 T/C cg23649088 chr2:200775458 C2orf69 0.55 6.01 0.31 4.94e-9 Schizophrenia; CRC cis rs12477438 0.765 rs4851183 chr2:99629149 G/T cg26064155 chr2:99771622 LIPT1;TSGA10 -0.62 -8.53 -0.43 5.31e-16 Chronic sinus infection; CRC cis rs7223966 1.000 rs2874121 chr17:61731024 C/T cg23090583 chr17:61904693 PSMC5;FTSJ3 0.49 6.11 0.32 2.75e-9 Hip circumference adjusted for BMI;Body mass index; CRC cis rs4481887 0.535 rs7512756 chr1:248362179 T/C cg00666640 chr1:248458726 OR2T12 0.44 7.07 0.36 9.39e-12 Common traits (Other); CRC cis rs3823572 0.542 rs62470445 chr7:133630961 T/C cg03336402 chr7:133662267 EXOC4 0.67 10.32 0.49 8.37e-22 Intelligence (multi-trait analysis); CRC trans rs3001167 0.609 rs10921619 chr1:194561967 C/T cg22004422 chr13:113740730 MCF2L -0.61 -6.19 -0.32 1.78e-9 Obesity-related traits; CRC cis rs2304069 0.913 rs3812009 chr5:149380159 G/C cg22760475 chr5:149380129 HMGXB3;TIGD6 0.89 10.12 0.49 3.87e-21 HIV-1 control; CRC cis rs16975963 0.793 rs73034946 chr19:38460493 T/C cg15135657 chr19:38346511 NA -0.44 -5.8 -0.3 1.52e-8 Longevity; CRC trans rs7937682 0.924 rs7938360 chr11:111539875 A/G cg18187862 chr3:45730750 SACM1L 0.45 6.61 0.34 1.59e-10 Primary sclerosing cholangitis; CRC cis rs4713118 0.629 rs203890 chr6:28022248 T/C cg18032046 chr6:28092343 ZSCAN16 -0.5 -6.38 -0.33 5.91e-10 Parkinson's disease; CRC cis rs11098499 0.954 rs7681544 chr4:120411255 T/C cg09307838 chr4:120376055 NA 0.7 10.94 0.52 5.58e-24 Corneal astigmatism; CRC cis rs7605827 0.897 rs6753675 chr2:15539706 C/T cg19274914 chr2:15703543 NA 0.4 5.94 0.31 7.2e-9 Educational attainment (years of education); CRC cis rs11758351 0.660 rs75156165 chr6:26235699 C/A cg08260959 chr6:26240920 HIST1H4F -0.35 -5.63 -0.3 3.78e-8 Gout;Renal underexcretion gout; CRC trans rs877282 1.000 rs12763443 chr10:771941 G/A cg22713356 chr15:30763199 NA 1.28 16.09 0.66 2.14e-43 Uric acid levels; CRC cis rs7618915 0.501 rs1866268 chr3:52719398 C/A cg15147215 chr3:52552868 STAB1 -0.65 -11.13 -0.52 1.19e-24 Bipolar disorder; CRC cis rs514406 0.679 rs499239 chr1:53310594 A/G cg27535305 chr1:53392650 SCP2 -0.43 -7.67 -0.39 2.02e-13 Monocyte count; CRC cis rs6973256 0.862 rs11762935 chr7:133327950 G/T cg10665199 chr7:133106180 EXOC4 -0.37 -5.69 -0.3 2.77e-8 Intelligence (multi-trait analysis); CRC cis rs12681287 0.640 rs7846090 chr8:87467724 A/T cg27223183 chr8:87520930 FAM82B -0.52 -7.47 -0.38 7.07e-13 Caudate activity during reward; CRC cis rs61996546 0.622 rs11637029 chr15:26836107 T/A cg15066197 chr15:26874202 GABRB3 -0.4 -5.83 -0.31 1.32e-8 Response to methotrexate in juvenile idiopathic arthritis; CRC cis rs950169 0.887 rs62029593 chr15:84955180 A/G cg17507749 chr15:85114479 UBE2QP1 0.74 10.59 0.5 9.91e-23 Schizophrenia; CRC cis rs9467603 0.547 rs4632883 chr6:25424191 A/G cg16898833 chr6:26189333 HIST1H4D -0.76 -5.81 -0.3 1.5e-8 Intelligence (multi-trait analysis); CRC cis rs4319547 1.000 rs7309390 chr12:123110422 A/G cg23029597 chr12:123009494 RSRC2 -0.63 -8.06 -0.41 1.42e-14 Body mass index; CRC cis rs7119 0.679 rs34075648 chr15:77847802 G/C cg27398640 chr15:77910606 LINGO1 -0.41 -6.83 -0.35 4.04e-11 Type 2 diabetes; CRC cis rs10504229 0.728 rs17215753 chr8:58153764 A/G cg02725872 chr8:58115012 NA -0.57 -9.07 -0.45 1.09e-17 Developmental language disorder (linguistic errors); CRC cis rs6429082 0.523 rs704718 chr1:235666159 A/T cg26050004 chr1:235667680 B3GALNT2 0.76 13.06 0.58 1.11e-31 Adiposity; CRC cis rs4727963 0.792 rs10953968 chr7:122716333 G/A cg03640110 chr7:122635026 TAS2R16 0.35 6.33 0.33 8.22e-10 Adverse response to chemotherapy (neutropenia/leucopenia) (docetaxel); CRC cis rs17376456 1.000 rs6867042 chr5:93555761 C/T cg25358565 chr5:93447407 FAM172A 1.05 9.72 0.47 8.7e-20 Diabetic retinopathy; CRC cis rs6120849 0.615 rs11167248 chr20:33538721 G/T cg24642439 chr20:33292090 TP53INP2 0.47 6.26 0.33 1.23e-9 Protein C levels; CRC cis rs9811920 0.529 rs793442 chr3:99581062 A/T cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G -0.46 -6.05 -0.32 3.86e-9 Axial length; CRC cis rs7772486 0.790 rs1832362 chr6:146179955 C/T cg05347473 chr6:146136440 FBXO30 0.36 5.61 0.3 4.32e-8 Lobe attachment (rater-scored or self-reported); CRC cis rs911555 0.692 rs7146215 chr14:103915908 A/G cg12935359 chr14:103987150 CKB 0.56 9.04 0.45 1.42e-17 Intelligence (multi-trait analysis); CRC cis rs9322193 0.884 rs1125 chr6:149979416 G/A cg00933542 chr6:150070202 PCMT1 0.3 5.76 0.3 1.94e-8 Lung cancer; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg00009970 chr18:48723811 MEX3C 0.41 6.55 0.34 2.22e-10 Liver disease severity in Alagille syndrome; CRC cis rs7618915 0.501 rs10865974 chr3:52718280 A/C cg18404041 chr3:52824283 ITIH1 0.4 8.52 0.43 5.87e-16 Bipolar disorder; CRC cis rs4689388 0.853 rs6446479 chr4:6291737 G/C cg14416269 chr4:6271139 WFS1 0.38 6.05 0.32 4.02e-9 Type 2 diabetes and other traits;Type 2 diabetes; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg12986726 chr20:48806920 CEBPB 0.42 5.99 0.31 5.63e-9 Response to antipsychotic treatment; CRC cis rs34375054 0.738 rs10773145 chr12:125625603 C/T cg06287003 chr12:125626642 AACS 0.49 7.52 0.38 5.28e-13 Post bronchodilator FEV1/FVC ratio; CRC cis rs6543140 0.964 rs918000 chr2:103067862 C/T cg03938978 chr2:103052716 IL18RAP 0.42 6.7 0.35 8.81e-11 Blood protein levels; CRC cis rs7827545 1.000 rs7832857 chr8:135565477 A/G cg17885191 chr8:135476712 NA 0.54 7.41 0.38 1.06e-12 Hypertension (SNP x SNP interaction); CRC cis rs4713118 0.824 rs9468225 chr6:27745719 T/G cg25164649 chr6:28176230 NA 0.62 8.16 0.41 7.1e-15 Parkinson's disease; CRC cis rs11585357 0.843 rs12095095 chr1:17625832 C/G cg08277548 chr1:17600880 PADI3 -0.71 -9.99 -0.48 1.07e-20 Hair shape; CRC cis rs11577318 0.853 rs4526602 chr1:26648034 C/T cg04990556 chr1:26633338 UBXN11 -0.47 -5.78 -0.3 1.75e-8 Granulocyte percentage of myeloid white cells; CRC cis rs6424115 0.965 rs2502986 chr1:24135292 G/T cg09473613 chr1:24152604 HMGCL 0.34 5.94 0.31 7.35e-9 Immature fraction of reticulocytes; CRC cis rs6570726 0.935 rs425717 chr6:145838620 A/T cg23711669 chr6:146136114 FBXO30 0.68 12.16 0.56 2.33e-28 Lobe attachment (rater-scored or self-reported); CRC cis rs763121 0.819 rs5757133 chr22:38947835 A/G cg06544989 chr22:39130855 UNC84B -0.41 -6.48 -0.34 3.42e-10 Menopause (age at onset); CRC cis rs4664293 0.867 rs13389662 chr2:160586437 A/G cg08347373 chr2:160653686 CD302 -0.47 -7.43 -0.38 9.32e-13 Monocyte percentage of white cells; CRC cis rs2153535 0.580 rs7747306 chr6:8453663 C/G cg07606381 chr6:8435919 SLC35B3 -0.65 -10.44 -0.5 3.11e-22 Motion sickness; CRC cis rs7591163 1.000 rs6744308 chr2:228711816 T/G cg23807890 chr2:228736357 WDR69 -0.51 -6.99 -0.36 1.56e-11 Blood pressure; CRC cis rs35306767 0.903 rs10508208 chr10:910983 C/T cg26597838 chr10:835615 NA 0.97 11.71 0.54 1.05e-26 Eosinophil percentage of granulocytes; CRC cis rs1799949 1.000 rs8176289 chr17:41206056 T/C cg19454999 chr17:41278357 BRCA1;NBR2 0.54 8.53 0.43 5.37e-16 Menopause (age at onset); CRC cis rs12188164 0.965 rs41282625 chr5:475626 C/G cg17553881 chr5:443987 EXOC3;C5orf55 -0.37 -7.68 -0.39 1.79e-13 Cystic fibrosis severity; CRC cis rs1862618 0.853 rs252916 chr5:56121788 G/C cg22800045 chr5:56110881 MAP3K1 0.53 5.94 0.31 7.35e-9 Initial pursuit acceleration; CRC cis rs4148883 0.689 rs1869458 chr4:100024728 C/G cg12011299 chr4:100065546 ADH4 0.54 11.93 0.55 1.64e-27 Alcohol dependence; CRC trans rs66573146 1.000 rs56074877 chr4:6990374 C/T cg07817883 chr1:32538562 TMEM39B 1.24 11.59 0.54 2.8e-26 Granulocyte percentage of myeloid white cells; CRC cis rs62458065 0.713 rs3801329 chr7:32496956 A/C cg20159608 chr7:32802032 NA -0.6 -7.29 -0.37 2.3e-12 Metabolite levels (HVA/MHPG ratio); CRC cis rs7091068 0.536 rs6583901 chr10:95409998 C/T cg20715218 chr10:95462985 C10orf4 -0.45 -5.9 -0.31 8.92e-9 Urinary tract infection frequency; CRC cis rs4594175 0.926 rs116372620 chr14:51599682 T/C cg23942311 chr14:51606299 NA 0.67 11.22 0.53 5.87e-25 Cancer; CRC cis rs4713118 0.615 rs57252182 chr6:27720249 C/A cg15786705 chr6:28176104 NA 0.49 7.01 0.36 1.36e-11 Parkinson's disease; CRC cis rs17767294 0.611 rs66487884 chr6:28202912 C/G cg25164649 chr6:28176230 NA 0.67 6.36 0.33 6.84e-10 Parkinson's disease; CRC trans rs7615952 0.546 rs2979306 chr3:125312130 C/A cg02560186 chr11:3602584 NA -0.58 -7.36 -0.38 1.52e-12 Blood pressure (smoking interaction); CRC cis rs4665809 0.590 rs35746418 chr2:26455002 C/G cg25036284 chr2:26402008 FAM59B 0.61 7.76 0.39 1.09e-13 Gut microbiome composition (summer); CRC cis rs6774721 1.000 rs6774721 chr3:49381898 G/A cg19401529 chr3:49056140 DALRD3 0.51 5.72 0.3 2.36e-8 Intelligence (multi-trait analysis); CRC cis rs11098499 0.909 rs1809406 chr4:120377122 G/A cg24375607 chr4:120327624 NA 0.5 7.73 0.39 1.3e-13 Corneal astigmatism; CRC trans rs12310956 0.532 rs10844707 chr12:33936089 T/C cg26384229 chr12:38710491 ALG10B 0.53 6.68 0.35 9.98e-11 Morning vs. evening chronotype; CRC cis rs11711311 1.000 rs7633832 chr3:113472292 T/C cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.51 -6.91 -0.36 2.49e-11 IgG glycosylation; CRC cis rs9911578 1.000 rs7223955 chr17:56917053 C/A cg05425664 chr17:57184151 TRIM37 -0.49 -7.72 -0.39 1.45e-13 Intelligence (multi-trait analysis); CRC cis rs7666738 1.000 rs2865983 chr4:99033352 C/T cg05340658 chr4:99064831 C4orf37 0.54 7.73 0.39 1.32e-13 Colonoscopy-negative controls vs population controls; CRC trans rs9825823 0.617 rs2083264 chr3:61074229 A/G cg22834172 chr17:37774349 NA 0.43 5.99 0.31 5.61e-9 Depressive symptom measurement or major depressive disorder; CRC trans rs800082 0.668 rs9856190 chr3:144288547 G/C cg24215973 chr2:240111563 HDAC4 -0.65 -10.25 -0.49 1.46e-21 Smoking behavior; CRC trans rs61931739 0.500 rs11053260 chr12:34530215 T/G cg13010199 chr12:38710504 ALG10B 0.45 6.52 0.34 2.65e-10 Morning vs. evening chronotype; CRC cis rs929354 0.742 rs10251112 chr7:156963524 A/G cg16102536 chr7:156981717 UBE3C 0.39 6.62 0.34 1.45e-10 Body mass index; CRC trans rs875971 0.660 rs2191268 chr7:66110224 C/T cg22007326 chr12:124069649 TMED2 -0.42 -6.6 -0.34 1.62e-10 Aortic root size; CRC cis rs1375194 0.606 rs2044644 chr2:33817559 A/G cg04131969 chr2:33951647 MYADML -0.51 -7.69 -0.39 1.75e-13 Response to antidepressants in depression; CRC cis rs2688608 0.620 rs7076525 chr10:75512797 C/T cg16540259 chr10:75572220 NDST2 0.38 5.78 0.3 1.73e-8 Inflammatory bowel disease; CRC cis rs12760731 0.720 rs12048834 chr1:178353998 A/G cg00404053 chr1:178313656 RASAL2 1.13 11.35 0.53 2.06e-25 Obesity-related traits; CRC cis rs7412746 0.658 rs12090215 chr1:150893660 C/A cg15448220 chr1:150897856 SETDB1 0.56 8.17 0.41 6.67e-15 Melanoma; CRC trans rs1814175 0.745 rs7483456 chr11:49774613 C/T cg21153622 chr11:89784906 NA -0.37 -5.98 -0.31 5.8e-9 Height; CRC cis rs6582630 0.519 rs4406888 chr12:38293312 A/C cg26384229 chr12:38710491 ALG10B 0.69 9.79 0.47 5.01e-20 Drug-induced liver injury (flucloxacillin); CRC cis rs1519814 1.000 rs1519814 chr8:121115024 T/G cg22335954 chr8:121166405 COL14A1 -0.55 -6.23 -0.32 1.45e-9 Breast cancer; CRC cis rs116095464 0.558 rs9687898 chr5:253952 A/G cg22857025 chr5:266934 NA -1.25 -16.78 -0.68 4.42e-46 Breast cancer; CRC cis rs12148488 0.966 rs1867149 chr15:75339993 C/T cg14664628 chr15:75095509 CSK 0.45 6.51 0.34 2.89e-10 Caffeine consumption; CRC cis rs7493 1.000 rs2299265 chr7:95048870 C/G cg07404485 chr7:94953653 PON1 -0.47 -6.15 -0.32 2.26e-9 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs6502050 0.842 rs7211808 chr17:80071244 T/C cg19223190 chr17:80058835 NA -0.45 -7.07 -0.36 9.57e-12 Life satisfaction; CRC cis rs7246967 0.673 rs62120125 chr19:22955099 T/A cg08271804 chr19:22816896 ZNF492 0.38 5.85 0.31 1.2e-8 Bronchopulmonary dysplasia; CRC cis rs7937682 0.889 rs1789361 chr11:111485334 T/C cg09085632 chr11:111637200 PPP2R1B -1.0 -19.99 -0.74 9.26e-59 Primary sclerosing cholangitis; CRC cis rs7552404 1.000 rs4949875 chr1:76173080 G/A cg22875332 chr1:76189707 ACADM 0.69 9.31 0.46 1.87e-18 Blood metabolite levels;Acylcarnitine levels; CRC cis rs3741151 0.773 rs11820577 chr11:73261424 C/G cg17517138 chr11:73019481 ARHGEF17 0.83 7.15 0.37 5.59e-12 GIP levels in response to oral glucose tolerance test (120 minutes); CRC cis rs11098499 0.955 rs56386062 chr4:120155135 T/C cg24375607 chr4:120327624 NA 0.44 6.86 0.35 3.46e-11 Corneal astigmatism; CRC trans rs1005277 0.579 rs1740745 chr10:38520056 T/C cg27523141 chr10:43048294 ZNF37B 0.47 6.9 0.36 2.69e-11 Extrinsic epigenetic age acceleration; CRC cis rs875971 0.660 rs10263935 chr7:66096028 A/G cg18876405 chr7:65276391 NA 0.6 10.8 0.51 1.77e-23 Aortic root size; CRC cis rs11997175 0.545 rs5005657 chr8:33668913 C/G ch.8.33884649F chr8:33765107 NA 0.39 5.76 0.3 1.9e-8 Body mass index; CRC cis rs4253772 0.513 rs6008700 chr22:46722560 C/T cg09491104 chr22:46646882 C22orf40 -0.4 -6.1 -0.32 3.04e-9 LDL cholesterol;Cholesterol, total; CRC cis rs3996993 0.809 rs2894805 chr6:52680600 C/T cg20803780 chr6:52668592 GSTA1 -0.36 -6.82 -0.35 4.3e-11 Hemoglobin concentration; CRC cis rs8078723 1.000 rs59925331 chr17:38169273 C/G cg17344932 chr17:38183730 MED24;SNORD124 -0.45 -7.01 -0.36 1.37e-11 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); CRC cis rs7927592 0.956 rs7116899 chr11:68385535 G/T cg16797656 chr11:68205561 LRP5 0.35 5.66 0.3 3.25e-8 Total body bone mineral density; CRC cis rs73206853 0.841 rs4131852 chr12:110812657 C/G cg12870014 chr12:110450643 ANKRD13A 0.75 8.17 0.41 6.62e-15 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC cis rs9359856 0.510 rs4053618 chr6:90459454 G/A cg13799429 chr6:90582589 CASP8AP2 0.77 10.0 0.48 1.01e-20 Bipolar disorder; CRC trans rs12478296 0.681 rs6598999 chr2:242994405 C/A cg06834434 chr14:75079333 LTBP2 0.55 7.19 0.37 4.5e-12 Obesity-related traits; CRC trans rs11098499 0.954 rs6838814 chr4:120392443 G/A cg25214090 chr10:38739885 LOC399744 0.66 10.65 0.51 6.15e-23 Corneal astigmatism; CRC cis rs9858542 1.000 rs9882740 chr3:49702484 T/C cg07274523 chr3:49395745 GPX1 0.48 6.21 0.32 1.57e-9 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs12913538 1.000 rs11071676 chr15:62889661 C/T cg09983546 chr15:62884068 NA -0.6 -9.72 -0.47 8.82e-20 Sleep depth; CRC trans rs9650657 0.615 rs11986935 chr8:10691549 T/A cg06636001 chr8:8085503 FLJ10661 -0.41 -6.18 -0.32 1.9e-9 Neuroticism; CRC cis rs17253792 0.822 rs7150841 chr14:56088986 T/C cg01858014 chr14:56050164 KTN1 -0.87 -7.23 -0.37 3.34e-12 Putamen volume; CRC cis rs832540 0.931 rs33319 chr5:56206675 C/A cg12311346 chr5:56204834 C5orf35 -0.52 -8.02 -0.4 1.82e-14 Coronary artery disease; CRC cis rs2836974 0.666 rs11910705 chr21:40685604 C/T cg06238570 chr21:40685208 BRWD1 -0.87 -14.13 -0.61 9.49e-36 Cognitive function; CRC cis rs7811142 1.000 rs11766752 chr7:100073292 A/G cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.05 14.87 0.63 1.3e-38 Platelet count; CRC cis rs1799949 1.000 rs8074136 chr17:41342313 A/C cg25072359 chr17:41440525 NA 0.45 6.87 0.35 3.13e-11 Menopause (age at onset); CRC cis rs739401 1.000 rs739401 chr11:3036324 C/T cg05729581 chr11:3078854 CARS 0.42 6.09 0.32 3.08e-9 Longevity; CRC cis rs4713118 0.739 rs2893931 chr6:27748010 G/A cg02683197 chr6:28174875 NA 0.66 8.59 0.43 3.46e-16 Parkinson's disease; CRC cis rs6700896 0.931 rs2211651 chr1:66156021 G/T cg04111102 chr1:66153794 NA 0.34 5.87 0.31 1.04e-8 C-reactive protein;Mean corpuscular volume;Mean corpuscular hemoglobin; CRC cis rs1712517 0.566 rs1163073 chr10:105022934 C/T cg04362960 chr10:104952993 NT5C2 0.48 6.43 0.33 4.45e-10 Migraine; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg18036873 chr19:10362545 MRPL4 0.43 6.18 0.32 1.86e-9 Intelligence (multi-trait analysis); CRC cis rs5750830 0.649 rs5757657 chr22:39798429 G/T cg05872129 chr22:39784769 NA -0.63 -12.59 -0.57 6.21e-30 Intelligence (multi-trait analysis); CRC cis rs9894429 0.646 rs8080391 chr17:79566319 A/T cg18240062 chr17:79603768 NPLOC4 -0.66 -11.83 -0.55 3.91e-27 Eye color traits; CRC trans rs9858542 0.903 rs11921590 chr3:49644193 T/C cg21665057 chr3:196295764 WDR53;FBXO45 -0.72 -9.38 -0.46 1.12e-18 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs1577917 0.958 rs3900313 chr6:86537154 A/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.49 -6.58 -0.34 1.82e-10 Response to antipsychotic treatment; CRC cis rs10071761 0.513 rs4957278 chr5:40361820 T/G cg09067459 chr5:40385259 NA -0.53 -7.11 -0.37 7.18e-12 Selective IgA deficiency; CRC cis rs2274273 0.624 rs72717738 chr14:55842761 C/G cg10130446 chr14:55658398 DLGAP5 -0.44 -6.15 -0.32 2.25e-9 Protein biomarker; CRC cis rs758324 0.947 rs6861174 chr5:131156129 A/G cg06307176 chr5:131281290 NA 0.42 6.18 0.32 1.92e-9 Alzheimer's disease in APOE e4- carriers; CRC cis rs13064411 0.518 rs2399480 chr3:113228599 T/C cg18753928 chr3:113234510 CCDC52 -0.53 -8.13 -0.41 8.8e-15 Response to simvastatin treatment (PCSK9 protein level change); CRC cis rs10450586 0.897 rs28416407 chr11:27308244 G/T cg10370305 chr11:27303972 NA 0.36 5.8 0.3 1.53e-8 Total body bone mineral density; CRC cis rs1223397 0.651 rs2458311 chr6:13310012 T/C cg20827128 chr6:13274284 PHACTR1 0.38 5.8 0.3 1.52e-8 Blood pressure; CRC cis rs1448094 0.617 rs1502800 chr12:86476255 A/G cg02569458 chr12:86230093 RASSF9 0.39 6.58 0.34 1.81e-10 Major depressive disorder; CRC cis rs6754311 0.731 rs13404551 chr2:136721995 T/C cg15123519 chr2:136567270 LCT -0.29 -5.63 -0.3 3.96e-8 Mosquito bite size; CRC cis rs6502050 0.835 rs66531647 chr17:80089022 G/T cg22110888 chr17:80059540 CCDC57 0.4 6.34 0.33 7.4e-10 Life satisfaction; CRC cis rs6908034 0.505 rs76391302 chr6:19819116 G/A cg02682789 chr6:19804855 NA 0.83 6.67 0.35 1.08e-10 Endometriosis;Deep ovarian and/or rectovaginal disease with dense adhesions; CRC cis rs10504229 0.683 rs62621195 chr8:58133964 G/A cg02725872 chr8:58115012 NA -0.64 -11.55 -0.54 3.85e-26 Developmental language disorder (linguistic errors); CRC cis rs9443189 0.855 rs1321161 chr6:76454182 G/A cg01950844 chr6:76311363 SENP6 -0.66 -8.89 -0.44 4.24e-17 Prostate cancer; CRC cis rs459193 1.000 rs256904 chr5:55810305 A/T cg26646659 chr5:55776364 NA 0.45 5.81 0.3 1.5e-8 Coronary artery disease;Type 2 diabetes;Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);Waist-to-hip ratio adjusted for BMI in non-smokers;Waist-to-hip ratio adjusted for BMI (smoking interaction);Waist-to-hip ratio adjusted for body mass index;Waist-hip ratio;Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg06887260 chr4:48271826 TEC 0.39 5.96 0.31 6.56e-9 Intelligence (multi-trait analysis); CRC cis rs9916302 0.904 rs34363096 chr17:37594294 G/A cg03013999 chr17:37608204 MED1 0.47 7.28 0.37 2.48e-12 Glomerular filtration rate (creatinine); CRC cis rs1983170 0.736 rs745731 chr1:92011467 G/T cg02896835 chr1:92012615 NA 0.54 6.65 0.34 1.25e-10 Eosinophil percentage of white cells; CRC cis rs4731207 0.689 rs2054585 chr7:124552447 T/C cg23710748 chr7:124431027 NA -0.37 -6.0 -0.31 5.3300000000000004e-09 Cutaneous malignant melanoma; CRC cis rs9486719 1.000 rs2273622 chr6:97058567 A/G cg06623918 chr6:96969491 KIAA0776 -0.81 -9.5 -0.46 4.35e-19 Migraine;Coronary artery disease; CRC trans rs7088591 0.558 rs57392412 chr10:59818661 T/C cg21239940 chr8:68870412 PREX2 0.54 6.01 0.31 4.93e-9 Blood pressure; CRC cis rs9457247 0.935 rs427824 chr6:167403918 T/G cg23791538 chr6:167370224 RNASET2 -0.37 -5.76 -0.3 1.95e-8 Crohn's disease; CRC cis rs79149102 0.579 rs7342591 chr15:75306863 C/T cg17294928 chr15:75287854 SCAMP5 0.55 5.76 0.3 1.95e-8 Lung cancer; CRC cis rs4132509 0.793 rs10803161 chr1:243990770 T/C cg21452805 chr1:244014465 NA 0.54 7.3 0.37 2.12e-12 RR interval (heart rate); CRC cis rs10493773 0.630 rs3753790 chr1:86174772 T/C cg00734567 chr1:86172782 ZNHIT6 -0.49 -7.41 -0.38 1.08e-12 Urate levels in overweight individuals; CRC cis rs539514 0.690 rs585233 chr13:76317973 A/G cg04757411 chr13:76259545 LMO7 0.35 5.9 0.31 9.19e-9 Type 1 diabetes; CRC cis rs7586879 0.828 rs10195271 chr2:25108650 A/C cg22495460 chr2:25135724 ADCY3 0.88 15.28 0.64 3.27e-40 Body mass index; CRC trans rs7395662 0.889 rs11039754 chr11:48475213 C/G cg21153622 chr11:89784906 NA -0.51 -8.08 -0.41 1.22e-14 HDL cholesterol; CRC cis rs6762 0.692 rs5030778 chr11:836008 T/C cg16425592 chr11:842748 TSPAN4;POLR2L -0.55 -8.15 -0.41 7.81e-15 Mean platelet volume; CRC cis rs6938 0.618 rs11633472 chr15:75184084 T/G cg05627522 chr15:75251581 NA 0.41 6.27 0.33 1.16e-9 Breast cancer; CRC cis rs270601 0.913 rs273916 chr5:131659830 C/A cg24060327 chr5:131705240 SLC22A5 -0.52 -7.66 -0.39 2.15e-13 Acylcarnitine levels; CRC cis rs1799949 0.965 rs8067269 chr17:41235799 C/T cg19454999 chr17:41278357 BRCA1;NBR2 0.4 6.05 0.32 3.9e-9 Menopause (age at onset); CRC cis rs9611565 0.694 rs202622 chr22:41825342 T/G cg06481639 chr22:41940642 POLR3H 0.53 5.78 0.3 1.72e-8 Vitiligo; CRC cis rs10242455 0.702 rs73401510 chr7:99065812 A/C cg18809830 chr7:99032528 PTCD1 -1.06 -7.83 -0.4 6.73e-14 Blood metabolite levels; CRC cis rs7173389 1.000 rs8039168 chr15:73664723 A/T cg01796676 chr15:73680284 NA 0.51 6.76 0.35 6.43e-11 Resting heart rate; CRC cis rs6448317 0.954 rs13116026 chr4:24922242 T/A cg21108841 chr4:24914750 CCDC149 -0.46 -6.06 -0.32 3.72e-9 Heschl's gyrus morphology; CRC cis rs10924970 1.000 rs7339935 chr1:235337761 T/C cg26050004 chr1:235667680 B3GALNT2 0.39 5.83 0.31 1.35e-8 Asthma; CRC cis rs9916302 0.851 rs4794810 chr17:37603774 T/C cg15445000 chr17:37608096 MED1 0.4 8.69 0.43 1.71e-16 Glomerular filtration rate (creatinine); CRC cis rs11719291 0.833 rs73080361 chr3:48832146 G/A cg00383909 chr3:49044727 WDR6 1.36 11.12 0.52 1.35e-24 Cognitive function; CRC cis rs2692947 0.644 rs1030864 chr2:96822373 A/G cg23100626 chr2:96804247 ASTL 0.3 7.97 0.4 2.62e-14 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; CRC cis rs17641971 0.684 rs4873094 chr8:49989578 G/T cg00325661 chr8:49890786 NA 0.37 6.22 0.32 1.51e-9 Blood metabolite levels; CRC cis rs77106637 0.789 rs76550717 chr11:72428172 A/G cg03713592 chr11:72463424 ARAP1 1.05 10.38 0.5 5.07e-22 Type 2 diabetes; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg11087747 chr19:41107377 LTBP4 0.43 6.06 0.32 3.67e-9 Response to antipsychotic treatment; CRC cis rs10779751 0.734 rs1148485 chr1:11148759 G/A cg08854313 chr1:11322531 MTOR 0.57 7.35 0.38 1.58e-12 Body mass index; CRC cis rs6951245 0.938 rs117729148 chr7:1108531 G/A cg26224354 chr7:1096374 C7orf50;GPR146 -0.94 -12.26 -0.56 9.81e-29 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs10504073 0.527 rs118032023 chr8:49926296 A/T cg00325661 chr8:49890786 NA 0.6 10.84 0.51 1.3e-23 Blood metabolite ratios; CRC cis rs1448094 0.817 rs7973694 chr12:86335589 A/G cg18827107 chr12:86230957 RASSF9 -0.42 -6.64 -0.34 1.28e-10 Major depressive disorder; CRC cis rs6424115 0.800 rs6665733 chr1:24200158 T/C cg15997130 chr1:24165203 NA 0.72 10.57 0.5 1.09e-22 Immature fraction of reticulocytes; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg11487532 chr11:44586968 CD82 0.42 6.64 0.34 1.27e-10 Liver disease severity in Alagille syndrome; CRC cis rs1475911 0.656 rs9980065 chr21:43528072 G/A cg19766460 chr21:43528205 UMODL1;C21orf128 1.25 18.05 0.71 4.12e-51 IgG glycosylation; CRC cis rs921968 0.541 rs6717433 chr2:219375711 G/C cg02176678 chr2:219576539 TTLL4 -0.61 -9.72 -0.47 8.32e-20 Mean corpuscular hemoglobin concentration; CRC cis rs754466 0.580 rs11002293 chr10:79537965 C/T cg26805224 chr10:79626177 DLG5 -0.49 -7.21 -0.37 3.91e-12 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs736408 0.609 rs13082960 chr3:52785168 A/C cg18099408 chr3:52552593 STAB1 -0.44 -7.16 -0.37 5.34e-12 Bipolar disorder; CRC cis rs1178968 1.000 rs2237285 chr7:72760213 C/T cg25889504 chr7:72793014 NA 0.53 5.93 0.31 7.73e-9 Triglyceride levels; CRC cis rs9649213 0.593 rs6970990 chr7:97925382 T/G cg21770322 chr7:97807741 LMTK2 0.52 8.47 0.42 8.1e-16 Prostate cancer (SNP x SNP interaction); CRC cis rs853679 0.546 rs483143 chr6:27846744 G/C cg26587870 chr6:27730563 NA -0.63 -6.39 -0.33 5.69e-10 Depression; CRC cis rs1552244 0.882 rs13088350 chr3:10044626 T/C cg10729496 chr3:10149963 C3orf24 0.49 6.34 0.33 7.69e-10 Alzheimer's disease; CRC trans rs2303319 0.504 rs12467625 chr2:162603387 C/A cg14875682 chr5:52083620 ITGA1;PELO -0.73 -6.16 -0.32 2.11e-9 Cognitive function; CRC cis rs2249694 0.520 rs7096203 chr10:135324505 A/C cg20169779 chr10:135381914 SYCE1 -0.54 -7.33 -0.37 1.76e-12 Obesity-related traits; CRC cis rs1005277 0.579 rs2505257 chr10:38372664 A/G cg25427524 chr10:38739819 LOC399744 -0.77 -13.55 -0.6 1.52e-33 Extrinsic epigenetic age acceleration; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg26072759 chr17:75277365 SEPT9 0.44 6.39 0.33 5.6e-10 Anxiety disorder; CRC cis rs5769707 0.967 rs9616327 chr22:50010891 G/A cg05373962 chr22:49881684 NA -0.39 -7.53 -0.38 4.97e-13 Monocyte count;Monocyte percentage of white cells; CRC cis rs6496044 0.568 rs7176291 chr15:86067398 T/C cg17133734 chr15:86042851 AKAP13 0.4 6.51 0.34 2.8e-10 Interstitial lung disease; CRC cis rs13256369 1.000 rs4841017 chr8:8577093 A/G cg00074818 chr8:8560427 CLDN23 0.34 6.43 0.33 4.44e-10 Obesity-related traits; CRC cis rs57994353 0.865 rs13290734 chr9:139330701 G/A cg14119001 chr9:139324193 INPP5E -0.48 -6.73 -0.35 7.46e-11 Eosinophil counts;Cutaneous squamous cell carcinoma; CRC cis rs4969178 0.930 rs12601079 chr17:76400329 G/A cg05887092 chr17:76393375 PGS1 0.56 10.03 0.48 7.75e-21 HDL cholesterol levels; CRC cis rs1008375 1.000 rs3815414 chr4:17606659 A/G cg04450456 chr4:17643702 FAM184B -0.37 -6.0 -0.31 5.34e-9 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs7618501 0.633 rs2526748 chr3:50080439 A/G cg05623727 chr3:50126028 RBM5 -0.43 -7.3 -0.37 2.18e-12 Intelligence (multi-trait analysis); CRC cis rs1153858 1.000 rs1820518 chr15:45694579 C/T cg10760299 chr15:45669010 GATM 0.51 7.78 0.39 9.59e-14 Homoarginine levels; CRC cis rs5753618 0.583 rs8141150 chr22:31800336 C/T cg22777020 chr22:31556080 RNF185 0.5 5.99 0.31 5.4e-9 Colorectal cancer; CRC cis rs4481887 0.927 rs7519334 chr1:248472076 C/T cg00666640 chr1:248458726 OR2T12 0.45 7.73 0.39 1.29e-13 Common traits (Other); CRC cis rs6933660 0.800 rs6931104 chr6:151786177 C/T cg14416726 chr6:151773293 C6orf211;RMND1 -0.64 -9.96 -0.48 1.32e-20 Menarche (age at onset); CRC cis rs6842047 1.000 rs6842047 chr4:187133576 A/C cg09526685 chr4:187126073 CYP4V2 0.46 6.52 0.34 2.72e-10 Blood protein levels; CRC cis rs4713118 0.662 rs9468271 chr6:28024570 A/G cg15845792 chr6:28175446 NA 0.95 13.85 0.61 1.07e-34 Parkinson's disease; CRC cis rs9914988 0.832 rs4795462 chr17:27130991 C/T cg12682573 chr17:27188876 MIR451;MIR144 0.58 7.99 0.4 2.37e-14 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs4780401 0.703 rs12921129 chr16:11769176 C/T cg01061890 chr16:11836724 TXNDC11 -0.44 -6.1 -0.32 2.95e-9 Rheumatoid arthritis; CRC cis rs11098499 0.820 rs28578366 chr4:120536905 A/G cg09307838 chr4:120376055 NA -0.69 -10.39 -0.5 4.75e-22 Corneal astigmatism; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg27343303 chr11:34380546 NA 0.42 6.15 0.32 2.28e-9 Response to antipsychotic treatment; CRC cis rs13343954 0.518 rs7252086 chr19:33534929 T/C cg27124370 chr19:33622961 WDR88 0.47 7.25 0.37 3.08e-12 Colorectal cancer; CRC trans rs16846053 0.792 rs55893794 chr2:162418751 G/A cg18122310 chr12:50236657 BCDIN3D -0.72 -6.04 -0.32 4.15e-9 Blood osmolality (transformed sodium); CRC cis rs4253311 0.520 rs7687818 chr4:187122060 A/G cg24794857 chr4:187113578 CYP4V2 0.4 5.99 0.31 5.5e-9 Plasma renin activity levels;Circulating chromogranin peptide levels;Blood metabolite levels; CRC cis rs2153535 0.580 rs7341206 chr6:8470489 T/G cg07606381 chr6:8435919 SLC35B3 0.68 10.9 0.51 8.26e-24 Motion sickness; CRC trans rs1997103 1.000 rs6958664 chr7:55404958 T/G cg20935933 chr6:143382018 AIG1 0.51 6.64 0.34 1.3e-10 QRS interval (sulfonylurea treatment interaction); CRC cis rs6570726 0.791 rs374478 chr6:145840022 C/T cg23711669 chr6:146136114 FBXO30 0.74 12.97 0.58 2.27e-31 Lobe attachment (rater-scored or self-reported); CRC cis rs4862750 0.914 rs10027250 chr4:187873460 T/C cg11301795 chr4:187892539 NA -0.83 -17.83 -0.7 3.17e-50 Lobe attachment (rater-scored or self-reported); CRC cis rs9902453 0.791 rs57719820 chr17:28335088 A/C cg26525008 chr17:28256777 EFCAB5;SSH2 -0.59 -8.79 -0.44 8.24e-17 Coffee consumption (cups per day); CRC cis rs77633900 0.772 rs2957612 chr15:76703688 C/T cg21673338 chr15:77095150 SCAPER -0.66 -5.62 -0.3 4.15e-8 Non-glioblastoma glioma;Glioma; CRC cis rs7618915 0.547 rs68021750 chr3:52624769 G/A cg05573699 chr3:52720067 GNL3;PBRM1 -0.46 -6.62 -0.34 1.44e-10 Bipolar disorder; CRC cis rs270601 0.909 rs2569265 chr5:131704519 T/C cg12564285 chr5:131593104 PDLIM4 -0.45 -7.6 -0.39 3.07e-13 Acylcarnitine levels; CRC cis rs1552244 0.554 rs6762397 chr3:10007840 C/T cg13047869 chr3:10149882 C3orf24 0.36 5.63 0.3 3.86e-8 Alzheimer's disease; CRC cis rs2732480 0.500 rs2450991 chr12:48651621 A/G cg21466736 chr12:48725269 NA -0.53 -7.99 -0.4 2.23e-14 Hemoglobin concentration;Red blood cell count;Hematocrit; CRC cis rs427943 0.750 rs6518214 chr21:46601699 A/C cg19498844 chr21:46707878 POFUT2;LOC642852 0.45 5.97 0.31 6.28e-9 Body mass index; CRC cis rs12999616 0.696 rs56035334 chr2:98329047 T/G cg26665480 chr2:98280029 ACTR1B 0.52 6.43 0.33 4.6e-10 Colorectal cancer; CRC cis rs6502050 0.805 rs7503095 chr17:80107354 G/A cg25804541 chr17:80189381 SLC16A3 -0.31 -5.97 -0.31 6.08e-9 Life satisfaction; CRC cis rs9534288 0.830 rs2404963 chr13:46632836 C/T cg15192986 chr13:46630673 CPB2 -0.78 -10.96 -0.52 5.02e-24 Blood protein levels; CRC cis rs7809950 0.678 rs2395869 chr7:106940098 C/A cg23024343 chr7:107201750 COG5 -0.64 -8.79 -0.44 8.75e-17 Coronary artery disease; CRC cis rs7251806 1 rs7251806 chr19:16499569 C/T cg10248733 chr19:16607483 C19orf44;CALR3 0.54 6.28 0.33 1.06e-9 Lymphocyte counts; CRC cis rs1048238 0.846 rs945417 chr1:16344625 C/G cg24140574 chr1:16342155 HSPB7 0.43 6.29 0.33 9.87e-10 Systolic blood pressure; CRC cis rs514406 0.679 rs545719 chr1:53304922 T/C cg24675658 chr1:53192096 ZYG11B -0.7 -10.52 -0.5 1.61e-22 Monocyte count; CRC cis rs4308124 0.708 rs6716091 chr2:111991133 C/T cg04571233 chr2:111982156 NA -0.54 -8.16 -0.41 7.04e-15 Vitiligo; CRC cis rs8105895 0.935 rs7253053 chr19:22245685 T/C cg02657401 chr19:22469223 NA -0.34 -5.65 -0.3 3.56e-8 Body mass index (change over time); CRC cis rs7215564 0.908 rs34143200 chr17:78673008 G/A cg09596252 chr17:78655493 RPTOR 0.55 6.09 0.32 3.09e-9 Myopia (pathological); CRC cis rs6754311 0.731 rs748841 chr2:136558157 C/T cg25344623 chr2:136566232 LCT 0.31 5.67 0.3 3.05e-8 Mosquito bite size; CRC cis rs55637647 0.515 rs7206699 chr16:88523815 A/G cg26899496 chr16:88551223 ZFPM1 -0.37 -5.84 -0.31 1.28e-8 Testicular germ cell tumor; CRC cis rs1215050 0.765 rs588851 chr4:98678247 C/T cg05340658 chr4:99064831 C4orf37 0.47 7.01 0.36 1.4e-11 Waist-to-hip ratio adjusted for body mass index; CRC cis rs6772849 0.805 rs13325747 chr3:128336023 G/A cg08795948 chr3:128337044 NA 0.34 6.03 0.32 4.38e-9 Monocyte percentage of white cells;Monocyte count; CRC cis rs10078 0.559 rs2672725 chr5:434981 G/C cg24955955 chr5:415729 AHRR 0.62 6.37 0.33 6.46e-10 Fat distribution (HIV); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg09740319 chr1:231004641 C1orf198 0.48 6.72 0.35 7.81e-11 Response to antipsychotic treatment; CRC cis rs2836974 0.836 rs8129355 chr21:40579869 A/G cg06238570 chr21:40685208 BRWD1 0.78 10.77 0.51 2.25e-23 Cognitive function; CRC cis rs4862750 0.872 rs10027252 chr4:187873462 T/G cg10295955 chr4:187884368 NA -1.0 -21.78 -0.77 9.59e-66 Lobe attachment (rater-scored or self-reported); CRC cis rs6860806 0.661 rs2136188 chr5:131577514 A/G cg27615366 chr5:131592974 PDLIM4 -0.29 -5.61 -0.3 4.21e-8 Breast cancer; CRC trans rs1814175 0.817 rs1319547 chr11:49916705 C/T cg15704280 chr7:45808275 SEPT13 -0.97 -18.78 -0.72 5.61e-54 Height; CRC cis rs9292777 0.720 rs60823023 chr5:40425810 T/C cg09067459 chr5:40385259 NA -0.55 -8.93 -0.44 3.12e-17 Crohn's disease;Multiple sclerosis; CRC cis rs1552244 0.938 rs7625049 chr3:10115619 C/T cg02579736 chr3:10068473 FANCD2;CIDECP 0.97 13.13 0.59 6.13e-32 Alzheimer's disease; CRC cis rs763121 0.776 rs5757177 chr22:39007174 A/C cg06544989 chr22:39130855 UNC84B 0.45 7.04 0.36 1.12e-11 Menopause (age at onset); CRC cis rs6582630 0.555 rs11182148 chr12:38464883 A/C cg13010199 chr12:38710504 ALG10B 0.48 6.51 0.34 2.82e-10 Drug-induced liver injury (flucloxacillin); CRC cis rs7827545 1.000 rs7463007 chr8:135567143 C/T cg07299736 chr8:135490787 ZFAT -0.37 -6.48 -0.34 3.41e-10 Hypertension (SNP x SNP interaction); CRC cis rs1971762 0.563 rs4759285 chr12:54079513 G/T cg06632207 chr12:54070931 ATP5G2 0.42 7.27 0.37 2.64e-12 Height; CRC cis rs10504229 1.000 rs58053450 chr8:58173348 T/C cg24829409 chr8:58192753 C8orf71 -0.68 -11.34 -0.53 2.27e-25 Developmental language disorder (linguistic errors); CRC cis rs758324 0.947 rs10478989 chr5:131116055 A/G cg06307176 chr5:131281290 NA 0.43 6.38 0.33 6.19e-10 Alzheimer's disease in APOE e4- carriers; CRC trans rs2303319 0.504 rs12470590 chr2:162493102 A/G cg22988483 chr14:93581567 ITPK1 -0.67 -6.04 -0.32 4.16e-9 Cognitive function; CRC cis rs798554 0.757 rs1182176 chr7:2874601 A/G cg04166393 chr7:2884313 GNA12 0.46 6.4 0.33 5.27e-10 Height; CRC cis rs11155671 0.530 rs9322228 chr6:150209309 C/G cg07701084 chr6:150067640 NUP43 0.49 7.2 0.37 4.19e-12 Testicular germ cell tumor; CRC cis rs6062302 0.522 rs13043255 chr20:62218916 C/G cg16989086 chr20:62203971 PRIC285 0.47 5.99 0.31 5.44e-9 Glioblastoma; CRC cis rs7772486 0.754 rs9390358 chr6:146145678 C/T cg23711669 chr6:146136114 FBXO30 0.73 12.61 0.57 5.06e-30 Lobe attachment (rater-scored or self-reported); CRC cis rs8077889 1.000 rs113919636 chr17:41877740 A/C cg16892393 chr17:41919603 NA 0.5 7.23 0.37 3.48e-12 Triglycerides; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg25762580 chr7:108210082 THAP5;DNAJB9 0.48 6.63 0.34 1.36e-10 Response to antipsychotic treatment; CRC trans rs2727020 0.681 rs1976901 chr11:49378697 T/C cg11707556 chr5:10655725 ANKRD33B -0.36 -6.61 -0.34 1.58e-10 Coronary artery disease; CRC cis rs4478858 0.735 rs6685728 chr1:31802550 T/C cg00250761 chr1:31883323 NA -0.44 -8.5 -0.42 6.71e-16 Alcohol dependence; CRC cis rs4443100 0.670 rs13056137 chr22:23407261 C/A cg14186256 chr22:23484241 RTDR1 0.46 5.87 0.31 1.07e-8 Serum parathyroid hormone levels; CRC trans rs6703335 0.870 rs10803142 chr1:243598234 A/G cg04467838 chr17:27071119 TRAF4 0.49 6.88 0.35 3.03e-11 Schizophrenia;Schizophrenia, schizoaffective disorder or bipolar disorder; CRC cis rs798554 0.757 rs1182187 chr7:2870454 T/G cg14895029 chr7:2775587 GNA12 -0.41 -6.01 -0.31 5.03e-9 Height; CRC cis rs1707322 0.721 rs11211166 chr1:46157942 G/A cg03146154 chr1:46216737 IPP 0.67 9.82 0.48 3.93e-20 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs6141769 0.542 rs28730896 chr20:31295844 A/G cg13636640 chr20:31349939 DNMT3B -0.39 -5.83 -0.31 1.34e-8 Subjective well-being; CRC cis rs2032447 0.798 rs807214 chr6:26061769 G/C cg12588279 chr6:26043732 HIST1H2BB 0.43 6.23 0.32 1.42e-9 Intelligence (multi-trait analysis); CRC cis rs7647973 0.516 rs4499638 chr3:49202782 C/G cg20833759 chr3:49053208 WDR6;DALRD3 0.41 6.67 0.35 1.1e-10 Menarche (age at onset); CRC cis rs9894429 0.809 rs9889642 chr17:79591762 T/C cg13777783 chr17:79615861 NA -0.3 -5.71 -0.3 2.57e-8 Eye color traits; CRC cis rs1223397 0.938 rs3817742 chr6:13279552 T/C cg20827128 chr6:13274284 PHACTR1 0.53 6.41 0.33 4.94e-10 Blood pressure; CRC cis rs9640161 0.673 rs11773351 chr7:150030963 T/C cg13722127 chr7:150037890 RARRES2 0.47 7.07 0.36 9.06e-12 Blood protein levels;Circulating chemerin levels; CRC cis rs6087990 0.584 rs6058897 chr20:31398105 G/T cg11800794 chr20:31407338 MAPRE1 -0.35 -6.05 -0.32 3.93e-9 Ulcerative colitis; CRC cis rs1153858 1.000 rs9783731 chr15:45642884 C/T cg21132104 chr15:45694354 SPATA5L1 -0.58 -8.47 -0.42 8.06e-16 Homoarginine levels; CRC cis rs7591163 1.000 rs7591163 chr2:228715375 C/T cg20647610 chr2:228736258 WDR69 -0.5 -6.8 -0.35 4.83e-11 Blood pressure; CRC cis rs6762 0.692 rs5030778 chr11:836008 T/C cg11173246 chr11:841376 TSPAN4;POLR2L -0.34 -5.65 -0.3 3.5e-8 Mean platelet volume; CRC trans rs7819412 0.540 rs2409726 chr8:11043138 T/C cg06636001 chr8:8085503 FLJ10661 -0.45 -6.45 -0.34 4.02e-10 Triglycerides; CRC cis rs10504229 0.683 rs77548248 chr8:58117542 G/A cg04204079 chr8:58130323 NA -0.45 -5.74 -0.3 2.18e-8 Developmental language disorder (linguistic errors); CRC cis rs747650 0.504 rs10838644 chr11:47035761 G/A cg19486271 chr11:47235900 DDB2 -0.44 -5.88 -0.31 1.03e-8 Acne (severe); CRC cis rs951366 0.589 rs823099 chr1:205669322 C/A cg14893161 chr1:205819251 PM20D1 0.82 12.19 0.56 1.86e-28 Menarche (age at onset); CRC cis rs6714710 0.535 rs13006932 chr2:98370698 T/A cg26665480 chr2:98280029 ACTR1B 0.52 7.08 0.36 8.8e-12 Posterior cortical atrophy and Alzheimer's disease; CRC cis rs798554 0.655 rs798492 chr7:2799184 C/T cg04166393 chr7:2884313 GNA12 -0.38 -5.72 -0.3 2.36e-8 Height; CRC cis rs7811142 1.000 rs4463351 chr7:100078226 G/A cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.16 17.05 0.68 3.64e-47 Platelet count; CRC cis rs61897795 0.657 rs174589 chr11:61615803 C/G cg06781209 chr11:61594997 FADS2 0.47 5.95 0.31 6.75e-9 Neutrophil count;Sum basophil neutrophil counts; CRC cis rs9311676 0.656 rs11130632 chr3:58369324 C/T cg06643156 chr3:58380774 PXK 0.41 6.26 0.33 1.18e-9 Systemic lupus erythematosus; CRC cis rs1018836 0.923 rs9643308 chr8:91625399 A/C cg16814680 chr8:91681699 NA -0.75 -11.86 -0.55 3e-27 Ejection fraction in Tripanosoma cruzi seropositivity; CRC cis rs4727027 0.933 rs917122 chr7:148848257 T/C cg12479418 chr7:148823350 ZNF425;ZNF398 0.44 6.0 0.31 5.16e-9 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC cis rs853679 0.517 rs4713148 chr6:28115921 G/A cg23161317 chr6:28129485 ZNF389 0.53 6.43 0.33 4.52e-10 Depression; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg16196758 chr18:47901430 SKA1 0.45 6.16 0.32 2.11e-9 Anxiety disorder; CRC cis rs35146811 0.771 rs1060544 chr7:99613476 C/T cg03265037 chr7:99691720 MIR25;MCM7;MIR106B;MIR93 0.43 5.68 0.3 3.04e-8 Coronary artery disease; CRC trans rs7615952 0.546 rs111812401 chr3:125361495 G/A cg02007433 chr3:129722099 NA -0.5 -6.22 -0.32 1.48e-9 Blood pressure (smoking interaction); CRC cis rs6834538 0.538 rs13145085 chr4:113414871 A/C cg10021238 chr4:113569128 MIR367;LARP7 -0.37 -5.76 -0.3 1.92e-8 Free thyroxine concentration; CRC cis rs9322193 0.962 rs1413655 chr6:150142951 A/G cg05861140 chr6:150128134 PCMT1 -0.43 -6.86 -0.35 3.37e-11 Lung cancer; CRC cis rs1707322 0.963 rs4508055 chr1:46257731 A/T cg06784218 chr1:46089804 CCDC17 0.59 10.38 0.5 4.93e-22 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs6951245 1.000 rs77083167 chr7:1071823 C/T cg21664854 chr7:1097933 C7orf50;GPR146 0.79 8.92 0.44 3.39e-17 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs2120019 0.938 rs2120020 chr15:75316845 T/C cg11632617 chr15:75315747 PPCDC -0.56 -7.74 -0.39 1.23e-13 Blood trace element (Zn levels); CRC cis rs853679 0.517 rs9468298 chr6:28122345 A/G cg15786705 chr6:28176104 NA 0.78 9.83 0.48 3.57e-20 Depression; CRC cis rs72627509 0.767 rs6853156 chr4:57774843 C/T cg26694713 chr4:57773883 REST 0.47 5.77 0.3 1.83e-8 Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); CRC cis rs4654899 0.865 rs12131353 chr1:21321163 C/G cg02927042 chr1:21476669 EIF4G3 -0.52 -8.32 -0.42 2.33e-15 Superior frontal gyrus grey matter volume; CRC cis rs2115630 0.645 rs6496284 chr15:85178270 A/G cg12501888 chr15:85177176 SCAND2 -0.46 -7.7 -0.39 1.65e-13 P wave terminal force; CRC cis rs853679 0.517 rs9380061 chr6:28132803 T/C cg02631126 chr6:28058918 ZSCAN12L1 0.29 5.91 0.31 8.38e-9 Depression; CRC cis rs11212617 0.967 rs227086 chr11:108244251 A/T cg01991180 chr11:108092276 ATM;NPAT 0.43 6.34 0.33 7.4e-10 Response to metformin in type 2 diabetes (glycemic); CRC cis rs950169 1.000 rs12902672 chr15:84716986 G/A cg17507749 chr15:85114479 UBE2QP1 0.78 12.03 0.55 6.93e-28 Schizophrenia; CRC cis rs875971 0.522 rs1880556 chr7:65432544 T/C cg11764359 chr7:65958608 NA 0.51 7.85 0.4 6e-14 Aortic root size; CRC cis rs262150 0.851 rs2527224 chr7:158769198 G/A cg12590608 chr7:158785262 NA 0.5 9.24 0.45 3.12e-18 Facial morphology (factor 20); CRC cis rs4253772 0.591 rs6007795 chr22:46686792 C/G cg09491104 chr22:46646882 C22orf40 -0.4 -6.27 -0.33 1.12e-9 LDL cholesterol;Cholesterol, total; CRC cis rs6088580 0.619 rs1205335 chr20:32927507 C/T cg08999081 chr20:33150536 PIGU -0.64 -12.06 -0.55 5.47e-28 Glomerular filtration rate (creatinine); CRC cis rs4804416 1.000 rs4804414 chr19:7223785 C/T cg09779027 chr19:7224513 INSR 0.65 10.9 0.52 7.79e-24 Thyroid hormone levels;Hypothyroidism; CRC cis rs7762018 0.769 rs74838157 chr6:170077323 G/A cg24289452 chr6:170231220 NA -0.67 -6.64 -0.34 1.32e-10 Thiazide-induced adverse metabolic effects in hypertensive patients; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg13063040 chr8:145669623 NFKBIL2 -0.43 -6.35 -0.33 7.3e-10 Myopia (pathological); CRC cis rs3126085 0.935 rs10788824 chr1:152161694 A/G cg09127314 chr1:152161683 NA 0.46 5.63 0.3 3.79e-8 Atopic dermatitis; CRC cis rs651907 0.557 rs7645391 chr3:101361506 C/G cg11279151 chr3:101281821 RG9MTD1 -0.57 -7.75 -0.39 1.12e-13 Colorectal cancer; CRC cis rs2019137 0.936 rs3811059 chr2:113962071 C/T cg21550016 chr2:113992930 PAX8;LOC440839;LOC654433 -0.52 -7.47 -0.38 7.46e-13 Lymphocyte counts; CRC cis rs9807989 0.507 rs6543133 chr2:103040177 A/T cg03938978 chr2:103052716 IL18RAP 0.58 9.91 0.48 1.95e-20 Asthma; CRC cis rs9914988 0.887 rs4795463 chr17:27146389 G/C cg07195577 chr17:27052828 TLCD1 0.41 5.92 0.31 7.89e-9 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs26868 0.690 rs26835 chr16:2237549 C/T cg02248941 chr16:2239361 CASKIN1 0.8 16.6 0.68 2.13e-45 Height; CRC cis rs4862750 0.794 rs7672272 chr4:187896774 T/G cg03647317 chr4:187891568 NA -0.53 -9.9 -0.48 2.14e-20 Lobe attachment (rater-scored or self-reported); CRC cis rs1448094 0.511 rs17279261 chr12:86162714 C/T cg02569458 chr12:86230093 RASSF9 0.51 8.39 0.42 1.44e-15 Major depressive disorder; CRC cis rs7666738 0.830 rs7696715 chr4:98938486 T/C cg05340658 chr4:99064831 C4orf37 0.6 9.35 0.46 1.41e-18 Colonoscopy-negative controls vs population controls; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg27281285 chr12:120315368 CIT 0.52 6.7 0.35 8.84e-11 Thyroid stimulating hormone; CRC cis rs1448094 0.842 rs7301280 chr12:86455752 G/T cg18827107 chr12:86230957 RASSF9 0.36 5.7 0.3 2.65e-8 Major depressive disorder; CRC trans rs662064 0.852 rs617728 chr1:10566522 C/T cg20645065 chr1:21836138 ALPL -0.42 -6.27 -0.33 1.15e-9 Asthma; CRC cis rs7666738 0.830 rs1025204 chr4:99023441 G/A cg17366294 chr4:99064904 C4orf37 0.44 7.39 0.38 1.25e-12 Colonoscopy-negative controls vs population controls; CRC cis rs13082711 0.595 rs4973761 chr3:27358620 T/C cg02860705 chr3:27208620 NA 0.81 10.59 0.5 9.87e-23 Systolic blood pressure;Diastolic blood pressure;Blood pressure; CRC cis rs28386778 0.897 rs1982400 chr17:61793818 T/C cg06873352 chr17:61820015 STRADA 0.75 13.85 0.61 1.08e-34 Prudent dietary pattern; CRC cis rs4853036 0.904 rs62152020 chr2:70147664 C/T cg02498382 chr2:70120550 SNRNP27 -0.41 -5.84 -0.31 1.27e-8 Colorectal or endometrial cancer; CRC cis rs2762353 0.526 rs12215823 chr6:25726074 G/C cg17691542 chr6:26056736 HIST1H1C 0.4 5.7 0.3 2.72e-8 Blood metabolite levels; CRC cis rs6860806 0.695 rs11952099 chr5:131576772 A/G cg20512303 chr5:131592959 PDLIM4 0.37 7.22 0.37 3.61e-12 Breast cancer; CRC cis rs2735413 0.881 rs12927515 chr16:78080141 T/G cg04733911 chr16:78082701 NA -0.45 -7.44 -0.38 8.84e-13 Systolic blood pressure (alcohol consumption interaction); CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg02002494 chr3:119013045 CDGAP 0.52 6.82 0.35 4.47e-11 Thyroid stimulating hormone; CRC cis rs853679 0.607 rs33932084 chr6:28268824 A/G cg03623178 chr6:28175578 NA 0.83 5.76 0.3 1.93e-8 Depression; CRC cis rs7552404 1.000 rs4949876 chr1:76173377 C/T cg22875332 chr1:76189707 ACADM 0.69 9.24 0.45 3.2e-18 Blood metabolite levels;Acylcarnitine levels; CRC cis rs853679 0.517 rs4711165 chr6:28115184 T/G cg23161317 chr6:28129485 ZNF389 0.53 6.43 0.33 4.52e-10 Depression; CRC cis rs1506636 0.720 rs2456552 chr7:123441400 A/G cg03229431 chr7:123269106 ASB15 0.5 8.09 0.41 1.2e-14 Plateletcrit;Platelet count; CRC trans rs7873102 0.702 rs7028020 chr9:38007747 C/T cg22924838 chr2:200715629 NA -0.41 -6.23 -0.32 1.45e-9 Brain structure; CRC cis rs172166 0.694 rs536704 chr6:28092603 T/G cg26587870 chr6:27730563 NA -0.37 -5.69 -0.3 2.87e-8 Cardiac Troponin-T levels; CRC cis rs736408 0.812 rs4687654 chr3:52827566 G/A cg10802521 chr3:52805072 NEK4 -0.48 -6.63 -0.34 1.37e-10 Bipolar disorder; CRC cis rs2227564 0.620 rs11000787 chr10:75584383 T/C cg16540259 chr10:75572220 NDST2 0.5 7.6 0.39 3.15e-13 Crohn's disease;Inflammatory bowel disease; CRC cis rs514406 0.893 rs499195 chr1:53344907 C/T cg25767906 chr1:53392781 SCP2 -0.49 -7.99 -0.4 2.23e-14 Monocyte count; CRC cis rs7811142 0.830 rs705866 chr7:99965285 T/C cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.1 14.45 0.62 5.43e-37 Platelet count; CRC cis rs9443645 0.901 rs12193319 chr6:79583437 C/A cg05283184 chr6:79620031 NA -0.58 -9.37 -0.46 1.21e-18 Intelligence (multi-trait analysis); CRC cis rs7147624 0.882 rs7141367 chr14:65938641 C/T cg03016385 chr14:66212404 NA -1.06 -10.96 -0.52 4.88e-24 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs11677416 1.000 rs1304037 chr2:113532236 C/T cg27083787 chr2:113543245 IL1A -0.44 -6.31 -0.33 9.06e-10 Response to antipsychotic treatment in schizophrenia (working memory); CRC cis rs1153858 1.000 rs56669689 chr15:45637729 A/C cg21132104 chr15:45694354 SPATA5L1 0.58 8.6 0.43 3.24e-16 Homoarginine levels; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg08322149 chr10:46222875 FAM21C 0.5 7.11 0.36 7.07e-12 Response to antipsychotic treatment; CRC cis rs875971 1.000 rs6460295 chr7:65882728 T/C cg12463550 chr7:65579703 CRCP 0.48 6.96 0.36 1.89e-11 Aortic root size; CRC cis rs3736485 0.868 rs60060794 chr15:51937181 A/G cg08986416 chr15:51914746 DMXL2 -0.47 -6.55 -0.34 2.16e-10 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs7927771 1.000 rs34910028 chr11:47758449 T/C cg05585544 chr11:47624801 NA -0.62 -10.84 -0.51 1.26e-23 Subjective well-being; CRC cis rs11792861 0.591 rs7044275 chr9:111717138 T/C cg14432460 chr9:111696404 IKBKAP;C9orf6 0.51 7.29 0.37 2.32e-12 Menarche (age at onset); CRC cis rs6502050 0.835 rs67634087 chr17:80118168 C/T cg13198984 chr17:80129470 CCDC57 0.48 8.31 0.42 2.62e-15 Life satisfaction; CRC cis rs17270561 0.609 rs4711097 chr6:25732314 C/T cg16482183 chr6:26056742 HIST1H1C 0.83 10.62 0.51 7.43e-23 Iron status biomarkers; CRC cis rs1799949 1.000 rs8176120 chr17:41261233 C/T cg19454999 chr17:41278357 BRCA1;NBR2 0.56 8.89 0.44 4.26e-17 Menopause (age at onset); CRC cis rs1065852 0.526 rs9623490 chr22:42398266 G/C cg22189786 chr22:42395067 WBP2NL 0.44 6.44 0.33 4.33e-10 Response to serotonin reuptake inhibitors in major depressive disorder (plasma drug and metabolite levels); CRC cis rs1670533 1.000 rs2290408 chr4:1067267 A/C cg27284194 chr4:1044797 NA -0.47 -5.98 -0.31 5.94e-9 Recombination rate (females); CRC cis rs597539 0.652 rs478647 chr11:68700424 C/T cg06112835 chr11:68658793 MRPL21 0.42 6.71 0.35 8.28e-11 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs9486719 1.000 rs3798296 chr6:97052286 G/A cg18709589 chr6:96969512 KIAA0776 -0.51 -5.85 -0.31 1.21e-8 Migraine;Coronary artery disease; CRC cis rs2840044 1.000 rs2840044 chr17:33892068 A/G cg05299278 chr17:33885742 SLFN14 -0.39 -5.96 -0.31 6.64e-9 Response to radiotherapy in cancer (late toxicity); CRC cis rs6543140 0.964 rs4851578 chr2:103028951 T/G cg04239558 chr2:103089729 SLC9A4 0.37 6.4 0.33 5.27e-10 Blood protein levels; CRC cis rs9309711 0.689 rs4535075 chr2:3481716 T/C cg15541040 chr2:3486749 NA -0.52 -8.37 -0.42 1.68e-15 Neurofibrillary tangles; CRC cis rs4713118 0.955 rs9380012 chr6:27684654 A/G cg20933634 chr6:27740509 NA 0.57 8.08 0.41 1.24e-14 Parkinson's disease; CRC cis rs3772130 0.923 rs13090798 chr3:121482768 C/A cg20356878 chr3:121714668 ILDR1 0.51 7.9 0.4 4.1e-14 Cognitive performance; CRC cis rs6460942 0.749 rs74834695 chr7:12464779 G/A cg20607287 chr7:12443886 VWDE -0.66 -6.93 -0.36 2.17e-11 Coronary artery disease; CRC cis rs11212617 0.967 rs3781868 chr11:108059569 T/G cg14761454 chr11:108092087 ATM;NPAT 0.43 6.54 0.34 2.31e-10 Response to metformin in type 2 diabetes (glycemic); CRC cis rs4820294 1.000 rs739139 chr22:38067011 C/G cg21798802 chr22:38057573 PDXP 0.47 7.69 0.39 1.71e-13 Fat distribution (HIV); CRC trans rs1814175 0.817 rs7950856 chr11:49976394 C/T cg21153622 chr11:89784906 NA -0.37 -5.97 -0.31 6.05e-9 Height; CRC cis rs10504229 0.593 rs4738567 chr8:57997033 A/C cg02725872 chr8:58115012 NA -0.43 -6.63 -0.34 1.38e-10 Developmental language disorder (linguistic errors); CRC cis rs4862750 0.758 rs2375915 chr4:187896255 A/C cg11301795 chr4:187892539 NA -0.86 -19.72 -0.74 1.09e-57 Lobe attachment (rater-scored or self-reported); CRC cis rs13191362 0.935 rs66923841 chr6:163177317 C/T cg21926612 chr6:163149169 PACRG;PARK2 0.95 12.4 0.56 3.15e-29 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg13083004 chr1:23809994 ASAP3 0.35 6.11 0.32 2.81e-9 Liver disease severity in Alagille syndrome; CRC trans rs877282 0.898 rs10904546 chr10:757222 A/G cg22713356 chr15:30763199 NA 1.24 14.62 0.63 1.19e-37 Uric acid levels; CRC cis rs938554 0.513 rs10939650 chr4:9998440 C/T cg11266682 chr4:10021025 SLC2A9 0.35 6.23 0.32 1.41e-9 Blood metabolite levels; CRC cis rs10751667 0.666 rs10902255 chr11:967268 T/C cg01483505 chr11:975446 AP2A2 0.46 7.66 0.39 2.11e-13 Alzheimer's disease (late onset); CRC cis rs7091068 0.671 rs620890 chr10:95405424 G/A cg20715218 chr10:95462985 C10orf4 -0.47 -5.65 -0.3 3.4e-8 Urinary tract infection frequency; CRC trans rs9956878 0.555 rs8085188 chr18:73544676 A/G cg17695382 chr2:61697821 USP34 -0.38 -5.98 -0.31 5.68e-9 Obesity-related traits; CRC cis rs2976388 0.609 rs2717602 chr8:143805683 G/A cg05569086 chr8:143859399 LYNX1 0.38 6.54 0.34 2.4e-10 Urinary tract infection frequency; CRC cis rs77861329 0.748 rs6786592 chr3:52196241 T/C cg08692210 chr3:52188851 WDR51A 0.5 5.92 0.31 7.91e-9 Macrophage inflammatory protein 1b levels; CRC cis rs1055129 0.584 rs9895947 chr17:73908566 A/C cg14829360 chr17:73884958 NA -0.34 -5.75 -0.3 2.09e-8 White matter hyperintensity burden; CRC cis rs2836950 0.502 rs12627205 chr21:40630027 C/T cg11644478 chr21:40555479 PSMG1 -0.46 -6.79 -0.35 5.33e-11 Menarche (age at onset); CRC cis rs4713118 0.869 rs6914924 chr6:27711530 C/T cg02683197 chr6:28174875 NA 0.63 8.62 0.43 2.81e-16 Parkinson's disease; CRC cis rs12188164 0.965 rs41282625 chr5:475626 C/G cg26850624 chr5:429559 AHRR -0.78 -12.96 -0.58 2.68e-31 Cystic fibrosis severity; CRC cis rs3859192 0.561 rs12453343 chr17:38181176 C/A cg17467752 chr17:38218738 THRA -0.51 -7.48 -0.38 7.02e-13 White blood cell count; CRC cis rs709400 0.859 rs7693 chr14:104023704 C/T cg12935359 chr14:103987150 CKB -0.38 -5.97 -0.31 6.15e-9 Body mass index; CRC cis rs4561483 0.801 rs8061189 chr16:11951749 C/G cg08843971 chr16:11963173 GSPT1 0.62 9.76 0.47 6.12e-20 Testicular germ cell tumor; CRC trans rs6580649 0.883 rs7967762 chr12:48420214 C/T cg09545894 chr13:24008532 SACS 0.45 6.15 0.32 2.2e-9 Lung cancer; CRC cis rs9311474 0.935 rs7622851 chr3:52333671 C/G cg08222913 chr3:52553049 STAB1 -0.37 -7.02 -0.36 1.28e-11 Electroencephalogram traits; CRC cis rs2455601 1.000 rs56336128 chr11:8908299 G/A cg21881798 chr11:8931708 C11orf17;ST5 -0.55 -5.61 -0.3 4.41e-8 Schizophrenia; CRC cis rs7833986 0.501 rs2668007 chr8:56944111 C/T cg23139584 chr8:56987506 RPS20;SNORD54 0.78 9.58 0.47 2.56e-19 Height; CRC trans rs9784649 0.771 rs72755810 chr5:25039139 A/C cg08600765 chr20:34638493 LOC647979 -0.64 -8.52 -0.43 6.02e-16 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs9549367 0.789 rs12584008 chr13:113881228 C/T cg18105134 chr13:113819100 PROZ -0.73 -10.87 -0.51 1.05e-23 Platelet distribution width; CRC cis rs4481887 0.927 rs4453080 chr1:248474671 T/C cg13385794 chr1:248469461 NA 0.38 6.75 0.35 6.84e-11 Common traits (Other); CRC cis rs17162190 0.590 rs10902748 chr1:26817825 G/A cg17456097 chr1:26900765 RPS6KA1 0.44 6.08 0.32 3.39e-9 Mean corpuscular volume; CRC cis rs902774 0.585 rs7399070 chr12:53355678 G/T cg16329197 chr12:53359506 NA -1.05 -10.12 -0.49 3.94e-21 Prostate cancer; CRC cis rs9858542 0.953 rs9862080 chr3:49674458 A/G cg03060546 chr3:49711283 APEH -0.5 -6.65 -0.34 1.23e-10 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs968567 1.000 rs968567 chr11:61595564 C/T cg19610905 chr11:61596333 FADS2 -0.59 -7.12 -0.37 6.65e-12 Blood metabolite levels;Rheumatoid arthritis;Vitiligo;Glycerophospholipid levels; CRC cis rs3743266 0.507 rs56261931 chr15:60731618 C/T cg21667061 chr15:60772094 NARG2 0.38 6.11 0.32 2.78e-9 Menarche (age at onset); CRC cis rs13191362 1.000 rs35754151 chr6:163074867 A/G cg06582575 chr6:163149167 PACRG;PARK2 0.93 11.9 0.55 2.04e-27 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC trans rs1814175 0.817 rs12295885 chr11:50036762 T/G cg11707556 chr5:10655725 ANKRD33B -0.42 -8.03 -0.4 1.75e-14 Height; CRC cis rs4975709 0.589 rs1684967 chr5:1863055 G/C cg11168104 chr5:1857477 NA -0.36 -6.2 -0.32 1.66e-9 Cardiovascular disease risk factors; CRC cis rs9517313 0.897 rs4772087 chr13:99115041 A/G cg07423050 chr13:99094983 FARP1 0.61 9.4 0.46 9.66e-19 Neuroticism; CRC cis rs10540 1.000 rs61876323 chr11:462855 G/A cg03934478 chr11:495069 RNH1 0.66 7.41 0.38 1.1e-12 Body mass index; CRC cis rs11190604 1.000 rs2495745 chr10:102329075 A/G cg16342193 chr10:102329863 NA -0.33 -5.63 -0.3 3.84e-8 Palmitoleic acid (16:1n-7) levels; CRC cis rs11098499 1.000 rs6849889 chr4:120186348 A/C cg09307838 chr4:120376055 NA 0.62 9.59 0.47 2.2e-19 Corneal astigmatism; CRC cis rs6694672 0.717 rs2151135 chr1:197106604 C/T cg13682187 chr1:196946512 CFHR5 0.43 6.87 0.35 3.26e-11 Asthma; CRC cis rs2019137 0.539 rs6755040 chr2:113981137 T/C cg23564664 chr2:113997917 PAX8;LOC654433;LOC440839 -0.37 -6.16 -0.32 2.08e-9 Lymphocyte counts; CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg26770385 chr8:125486821 RNF139 0.38 6.07 0.32 3.44e-9 Obesity-related traits; CRC cis rs6912958 0.500 rs9342104 chr6:87798512 A/G cg04972856 chr6:88032051 C6orf162;GJB7 -0.32 -5.68 -0.3 2.91e-8 Monocyte percentage of white cells; CRC cis rs853679 0.550 rs9295762 chr6:28155418 C/T cg06470822 chr6:28175283 NA -0.98 -14.46 -0.62 5.05e-37 Depression; CRC cis rs4862750 0.874 rs6553027 chr4:187875777 T/C cg06074448 chr4:187884817 NA -0.59 -10.85 -0.51 1.2e-23 Lobe attachment (rater-scored or self-reported); CRC cis rs2576037 0.901 rs2576036 chr18:44587102 G/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.51 8.86 0.44 5.07e-17 Personality dimensions; CRC cis rs200986 1 rs200986 chr6:27824766 G/C cg06470822 chr6:28175283 NA 0.76 10.98 0.52 4.06e-24 Autism spectrum disorder or schizophrenia; CRC trans rs7937682 0.883 rs512669 chr11:111467893 G/A cg18187862 chr3:45730750 SACM1L 0.45 6.4 0.33 5.43e-10 Primary sclerosing cholangitis; CRC cis rs832540 0.629 rs6888317 chr5:56093307 A/G cg12311346 chr5:56204834 C5orf35 0.5 7.51 0.38 5.77e-13 Coronary artery disease; CRC cis rs4819052 0.851 rs13048789 chr21:46660714 A/G cg19498844 chr21:46707878 POFUT2;LOC642852 0.77 10.99 0.52 3.97e-24 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs72634258 0.554 rs68024107 chr1:7914066 G/C cg26816564 chr1:7831052 VAMP3 0.72 8.53 0.43 5.61e-16 Inflammatory bowel disease; CRC cis rs11971779 0.616 rs7784192 chr7:139039649 T/C cg23387468 chr7:139079360 LUC7L2 0.41 7.04 0.36 1.14e-11 Diisocyanate-induced asthma; CRC cis rs10504229 1.000 rs61998259 chr8:58192290 T/C cg02725872 chr8:58115012 NA -0.38 -6.43 -0.33 4.44e-10 Developmental language disorder (linguistic errors); CRC cis rs7615952 0.546 rs2976733 chr3:125414138 T/C cg11143507 chr3:125485238 NA -0.57 -7.37 -0.38 1.37e-12 Blood pressure (smoking interaction); CRC cis rs2836754 1.000 rs2836753 chr21:40291187 A/G cg02119577 chr21:40195074 ETS2 -0.36 -6.19 -0.32 1.82e-9 Crohn's disease;Body mass index; CRC cis rs637571 0.676 rs1151523 chr11:65665200 C/T cg26695010 chr11:65641043 EFEMP2 0.45 6.88 0.35 3.07e-11 Eosinophil percentage of white cells; CRC cis rs2749592 0.550 rs10764135 chr10:37866845 C/T cg25427524 chr10:38739819 LOC399744 0.67 11.1 0.52 1.53e-24 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs28386778 0.897 rs1062790 chr17:61896455 A/G cg25654072 chr17:61904446 PSMC5;FTSJ3 0.72 11.25 0.53 4.67e-25 Prudent dietary pattern; CRC cis rs73206853 0.563 rs1107652 chr12:111176213 A/G cg12870014 chr12:110450643 ANKRD13A 0.78 9.7 0.47 9.64e-20 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC cis rs7224685 0.501 rs2676276 chr17:3919981 C/T cg10724054 chr17:3904396 NA 0.45 7.88 0.4 4.76e-14 Type 2 diabetes; CRC cis rs7091068 0.518 rs4144097 chr10:95432480 A/C cg20715218 chr10:95462985 C10orf4 0.53 7.22 0.37 3.56e-12 Urinary tract infection frequency; CRC cis rs6502050 0.635 rs11867440 chr17:80147185 A/T cg02741985 chr17:80059408 CCDC57 0.44 7.18 0.37 4.6e-12 Life satisfaction; CRC cis rs2836974 0.897 rs11911112 chr21:40528346 A/C cg06238570 chr21:40685208 BRWD1 0.71 10.11 0.49 4.09e-21 Cognitive function; CRC cis rs8105895 0.935 rs10407250 chr19:22238151 G/A cg02657401 chr19:22469223 NA -0.34 -5.65 -0.3 3.56e-8 Body mass index (change over time); CRC cis rs10504229 1.000 rs56350499 chr8:58178139 C/T cg01721255 chr8:58191610 C8orf71 0.49 6.17 0.32 2e-9 Developmental language disorder (linguistic errors); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg23822915 chr6:84569161 CYB5R4 0.45 6.43 0.33 4.42e-10 Intelligence (multi-trait analysis); CRC cis rs9911578 1.000 rs654778 chr17:56736473 A/C cg12560992 chr17:57184187 TRIM37 0.9 16.62 0.68 1.89e-45 Intelligence (multi-trait analysis); CRC trans rs204595 0.965 rs10281881 chr7:20897865 A/C cg02372745 chr13:50365574 KPNA3 -0.47 -6.19 -0.32 1.75e-9 Depressive symptoms (stressful life events interaction); CRC cis rs4713118 0.588 rs200994 chr6:27813813 A/C cg19041857 chr6:27730383 NA 0.43 5.65 0.3 3.43e-8 Parkinson's disease; CRC trans rs7613875 0.654 rs3774751 chr3:50209053 G/T cg21659725 chr3:3221576 CRBN -0.52 -7.99 -0.4 2.28e-14 Body mass index; CRC cis rs12142240 0.660 rs72886903 chr1:46813860 C/T cg14993813 chr1:46806288 NSUN4 -0.5 -6.42 -0.33 4.75e-10 Menopause (age at onset); CRC cis rs7178572 0.633 rs11854328 chr15:77840129 A/G cg22256960 chr15:77711686 NA -0.64 -9.26 -0.45 2.71e-18 Type 2 diabetes; CRC cis rs62432291 0.681 rs417719 chr6:159658042 C/T cg14500486 chr6:159655392 FNDC1 -0.75 -10.12 -0.49 3.83e-21 Joint mobility (Beighton score); CRC cis rs7618915 0.547 rs12487591 chr3:52642936 A/T cg18404041 chr3:52824283 ITIH1 -0.38 -7.9 -0.4 4.21e-14 Bipolar disorder; CRC cis rs546131 0.928 rs553789 chr11:34827579 G/A cg11058730 chr11:34937778 PDHX;APIP 0.49 7.19 0.37 4.41e-12 Lung disease severity in cystic fibrosis; CRC cis rs4713118 0.868 rs2893928 chr6:27738430 C/A cg15786705 chr6:28176104 NA 0.64 7.06 0.36 9.77e-12 Parkinson's disease; CRC cis rs9733 0.596 rs1136808 chr1:150702717 G/C cg18016565 chr1:150552671 MCL1 0.45 6.52 0.34 2.57e-10 Tonsillectomy; CRC cis rs7945705 0.747 rs2653605 chr11:8993309 C/G cg14711859 chr11:8959438 ASCL3 0.38 6.66 0.34 1.18e-10 Hemoglobin concentration; CRC cis rs2032447 0.832 rs6922788 chr6:26052291 C/T cg18357526 chr6:26021779 HIST1H4A 0.73 11.16 0.52 9.56e-25 Intelligence (multi-trait analysis); CRC cis rs2760061 0.624 rs10442629 chr1:228191070 T/A cg02753203 chr1:228287806 NA 0.8 11.87 0.55 2.76e-27 Diastolic blood pressure; CRC cis rs2011503 1.000 rs2916070 chr19:19524105 C/T cg11584989 chr19:19387371 SF4 0.56 6.52 0.34 2.67e-10 Bipolar disorder; CRC cis rs6942756 0.713 rs692597 chr7:129132554 T/G cg02491457 chr7:128862824 NA -0.51 -6.72 -0.35 7.97e-11 White matter hyperintensity burden; CRC cis rs4654899 0.931 rs10753506 chr1:21141022 A/G cg02927042 chr1:21476669 EIF4G3 0.47 7.53 0.38 5.02e-13 Superior frontal gyrus grey matter volume; CRC cis rs4713675 0.565 rs6904816 chr6:33676156 G/A cg14003231 chr6:33640908 ITPR3 0.51 8.28 0.42 3.03e-15 Plateletcrit; CRC cis rs3751196 0.808 rs78823917 chr12:104219073 T/C cg02344784 chr12:104178138 NT5DC3 0.71 7.27 0.37 2.63e-12 Sense of smell; CRC cis rs1059312 0.808 rs10847693 chr12:129292006 G/A cg09035930 chr12:129282057 SLC15A4 0.52 8.87 0.44 4.61e-17 Systemic lupus erythematosus; CRC cis rs992157 0.717 rs3817266 chr2:219142594 C/T cg00012203 chr2:219082015 ARPC2 -0.47 -7.16 -0.37 5.15e-12 Colorectal cancer; CRC cis rs62244186 0.520 rs2372828 chr3:44784949 A/G cg11003573 chr3:44754125 ZNF502 0.34 6.09 0.32 3.15e-9 Depressive symptoms; CRC cis rs7914558 0.933 rs1538204 chr10:104733893 T/A cg15744005 chr10:104629667 AS3MT -0.34 -7.4 -0.38 1.12e-12 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs1552244 0.608 rs7615408 chr3:10000186 A/G cg13047869 chr3:10149882 C3orf24 0.37 5.82 0.31 1.39e-8 Alzheimer's disease; CRC cis rs16852403 0.501 rs2862318 chr1:178180127 C/T cg00404053 chr1:178313656 RASAL2 0.5 6.59 0.34 1.74e-10 Childhood ear infection; CRC cis rs501120 0.657 rs589655 chr10:44745315 C/G cg09554077 chr10:44749378 NA 0.73 8.0 0.4 2.15e-14 Coronary artery disease;Coronary heart disease; CRC cis rs1059312 1.000 rs9738216 chr12:129281788 C/T cg04043695 chr12:129287642 SLC15A4 0.37 5.64 0.3 3.66e-8 Systemic lupus erythematosus; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg22195704 chr2:25016199 CENPO;C2orf79 0.39 6.02 0.31 4.61e-9 Intelligence (multi-trait analysis); CRC cis rs28386778 0.805 rs9911714 chr17:61828952 G/A cg11494091 chr17:61959527 GH2 0.63 10.69 0.51 4.21e-23 Prudent dietary pattern; CRC cis rs6540559 1.000 rs6659367 chr1:209982408 G/T cg22029157 chr1:209979665 IRF6 0.63 9.58 0.47 2.53e-19 Cleft lip with or without cleft palate; CRC cis rs6952808 0.582 rs871925 chr7:2047875 G/A cg22963979 chr7:1858916 MAD1L1 0.44 6.85 0.35 3.57e-11 Bipolar disorder and schizophrenia; CRC trans rs916888 0.821 rs199504 chr17:44861003 C/T cg10053473 chr17:62856997 LRRC37A3 0.72 8.47 0.42 8.11e-16 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs7591163 1.000 rs6436741 chr2:228714598 G/A cg14646075 chr2:228736089 WDR69 -0.45 -6.14 -0.32 2.43e-9 Blood pressure; CRC trans rs2303319 0.504 rs62189041 chr2:162599506 T/C cg10498984 chr16:28874827 SH2B1 -0.73 -6.3 -0.33 9.75e-10 Cognitive function; CRC cis rs9292777 0.897 rs11742570 chr5:40410584 C/T cg09067459 chr5:40385259 NA -0.52 -9.06 -0.45 1.23e-17 Crohn's disease;Multiple sclerosis; CRC cis rs7945705 0.902 rs7930026 chr11:9013639 T/C cg21881798 chr11:8931708 C11orf17;ST5 0.63 9.44 0.46 7.31e-19 Hemoglobin concentration; CRC cis rs12497850 0.805 rs11130176 chr3:48844077 A/G cg20833759 chr3:49053208 WDR6;DALRD3 0.53 9.22 0.45 3.73e-18 Parkinson's disease; CRC trans rs2303319 0.504 rs72877343 chr2:162607487 A/C cg22627826 chr19:1240265 ATP5D -0.72 -6.24 -0.33 1.32e-9 Cognitive function; CRC cis rs1878931 0.624 rs37810 chr16:3451881 C/T cg26668626 chr16:3451006 ZNF174;ZNF434 -0.57 -7.09 -0.36 8.22e-12 Body mass index (adult); CRC cis rs2032447 0.901 rs1540276 chr6:26028819 T/G cg12310025 chr6:25882481 NA -0.52 -7.19 -0.37 4.5e-12 Intelligence (multi-trait analysis); CRC cis rs11214589 0.774 rs877137 chr11:113256330 C/T cg14159747 chr11:113255604 NA 0.62 12.79 0.58 1.15e-30 Neuroticism; CRC cis rs1218582 0.682 rs12144978 chr1:154850445 G/A cg16680214 chr1:154839983 KCNN3 -0.54 -10.03 -0.48 7.66e-21 Prostate cancer; CRC cis rs7945705 0.967 rs1569408 chr11:8909732 G/A cg00186954 chr11:8933980 ST5;C11orf17 0.46 7.18 0.37 4.76e-12 Hemoglobin concentration; CRC cis rs6502050 0.761 rs12150321 chr17:80061558 T/C cg13198984 chr17:80129470 CCDC57 -0.39 -6.63 -0.34 1.41e-10 Life satisfaction; CRC cis rs561341 0.740 rs11080174 chr17:30208521 C/A cg13647721 chr17:30228624 UTP6 -0.62 -7.38 -0.38 1.26e-12 Hip circumference adjusted for BMI; CRC cis rs4819052 0.851 rs1006779 chr21:46670752 A/G cg02159808 chr21:46707872 POFUT2;LOC642852 0.46 6.13 0.32 2.58e-9 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs6502050 0.835 rs56232956 chr17:80078929 C/T cg13198984 chr17:80129470 CCDC57 -0.48 -8.58 -0.43 3.8e-16 Life satisfaction; CRC cis rs4474465 0.688 rs10793336 chr11:78281867 A/G cg27205649 chr11:78285834 NARS2 0.51 6.53 0.34 2.44e-10 Alzheimer's disease (survival time); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg27221266 chr10:96122679 NOC3L 0.45 6.3 0.33 9.6e-10 Response to antipsychotic treatment; CRC cis rs2275731 0.506 rs11254015 chr10:16522078 A/G cg04254609 chr10:16479192 PTER 0.43 5.82 0.31 1.37e-8 Bone fracture in osteoporosis; CRC cis rs11758351 0.660 rs77130538 chr6:26210723 T/C cg22723502 chr6:26240528 HIST1H4F -0.37 -6.09 -0.32 3.11e-9 Gout;Renal underexcretion gout; CRC cis rs12042938 0.600 rs1094656 chr1:231773675 T/C cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX 0.48 6.67 0.35 1.06e-10 Neuranatomic and neurocognitive phenotypes; CRC cis rs875971 0.862 rs3893216 chr7:65790707 G/C cg18252515 chr7:66147081 NA 0.42 5.96 0.31 6.5e-9 Aortic root size; CRC cis rs72781680 0.799 rs17508218 chr2:23976536 C/T cg08917208 chr2:24149416 ATAD2B 0.86 8.45 0.42 9.69e-16 Lymphocyte counts; CRC cis rs490234 0.812 rs13288963 chr9:128295198 G/A cg14078157 chr9:128172775 NA -0.39 -6.66 -0.34 1.18e-10 Mean arterial pressure; CRC cis rs10971721 0.822 rs10971758 chr9:33876069 T/G cg13495928 chr9:33750294 PRSS3 0.56 5.95 0.31 6.96e-9 Body mass index; CRC cis rs2836974 0.897 rs35391055 chr21:40525516 G/A cg11644478 chr21:40555479 PSMG1 0.82 13.39 0.59 6.26e-33 Cognitive function; CRC cis rs6860806 0.507 rs270606 chr5:131650867 A/G cg22638593 chr5:131593259 PDLIM4 0.41 6.6 0.34 1.67e-10 Breast cancer; CRC cis rs8192917 0.573 rs66505306 chr14:25078610 G/C cg01932691 chr14:25045625 CTSG -0.58 -5.72 -0.3 2.36e-8 Vitiligo; CRC cis rs2239547 0.522 rs9311485 chr3:52987645 T/G cg11645453 chr3:52864694 ITIH4 -0.53 -9.98 -0.48 1.17e-20 Schizophrenia; CRC cis rs3733585 0.699 rs7663097 chr4:9966791 T/C cg11266682 chr4:10021025 SLC2A9 -0.46 -9.35 -0.46 1.35e-18 Cleft plate (environmental tobacco smoke interaction); CRC trans rs12699921 0.632 rs2691613 chr7:17883981 G/A cg02066331 chr6:17282778 RBM24 -0.35 -6.08 -0.32 3.38e-9 Fibrinogen levels; CRC trans rs6956675 0.874 rs10266439 chr7:62647022 G/T cg01314568 chr7:57830625 NA -0.61 -8.84 -0.44 6.05e-17 Obesity-related traits; CRC cis rs8180040 1.000 rs807931 chr3:47389317 C/T cg02527881 chr3:46936655 PTH1R -0.38 -7.25 -0.37 3.05e-12 Colorectal cancer; CRC cis rs270601 0.633 rs733300 chr5:131572243 A/G cg11843238 chr5:131593191 PDLIM4 0.53 9.55 0.47 3e-19 Acylcarnitine levels; CRC cis rs763121 0.853 rs926299 chr22:39095698 C/G cg06022373 chr22:39101656 GTPBP1 0.81 13.33 0.59 1.05e-32 Menopause (age at onset); CRC cis rs6580649 0.943 rs1990029 chr12:48407987 C/T cg05342945 chr12:48394962 COL2A1 -0.43 -5.62 -0.3 4.14e-8 Lung cancer; CRC cis rs4073582 0.595 rs801736 chr11:65928430 A/T cg16950941 chr11:66035639 RAB1B 0.7 12.08 0.55 4.69e-28 Gout; CRC cis rs6963495 0.606 rs6969426 chr7:105147150 G/A cg02135003 chr7:105160482 PUS7 -0.89 -12.26 -0.56 9.87e-29 Bipolar disorder (body mass index interaction); CRC cis rs12893668 0.572 rs4900590 chr14:104146421 C/T cg01849466 chr14:104193079 ZFYVE21 -0.41 -6.06 -0.32 3.65e-9 Reticulocyte count; CRC cis rs10078 0.559 rs2671891 chr5:456386 A/G cg24955955 chr5:415729 AHRR 0.66 6.47 0.34 3.6e-10 Fat distribution (HIV); CRC cis rs10944 0.598 rs650304 chr5:78275892 G/A cg13121490 chr5:78280331 ARSB -0.46 -6.75 -0.35 6.56e-11 Blood and toenail selenium levels; CRC trans rs916888 0.687 rs199456 chr17:44797919 C/T cg23590916 chr17:43697445 MGC57346 0.71 7.23 0.37 3.48e-12 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs10504229 1.000 rs66796009 chr8:58174529 G/A cg24829409 chr8:58192753 C8orf71 -0.68 -11.38 -0.53 1.63e-25 Developmental language disorder (linguistic errors); CRC cis rs4888262 0.545 rs7342732 chr16:74698716 A/C cg01733217 chr16:74700730 RFWD3 0.81 12.57 0.57 7.2e-30 Testicular germ cell tumor; CRC cis rs763014 0.966 rs4984903 chr16:680695 A/G cg09263875 chr16:632152 PIGQ 0.79 12.62 0.57 4.62e-30 Height; CRC cis rs9467711 0.651 rs1045537 chr6:26096748 G/C cg19084075 chr6:26124329 HIST1H2AC;HIST1H2BC 0.62 5.77 0.3 1.84e-8 Autism spectrum disorder or schizophrenia; CRC cis rs1707322 1.000 rs1707317 chr1:46510642 C/T cg06784218 chr1:46089804 CCDC17 -0.6 -10.56 -0.5 1.25e-22 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs600626 0.588 rs10899112 chr11:75458518 T/C cg24262691 chr11:75473276 NA 0.5 7.27 0.37 2.71e-12 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CRC cis rs8067354 0.645 rs2645467 chr17:57854783 C/T cg13753209 chr17:57696993 CLTC 0.45 5.79 0.3 1.61e-8 Hemoglobin concentration; CRC cis rs9747201 0.889 rs4789784 chr17:80179213 G/A cg14673194 chr17:80132900 CCDC57 -0.47 -5.9 -0.31 9.26e-9 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs3751196 0.901 rs1550207 chr12:104210068 A/T cg02344784 chr12:104178138 NT5DC3 0.7 7.21 0.37 3.92e-12 Sense of smell; CRC cis rs9926296 0.572 rs8047581 chr16:89884502 C/T cg03388025 chr16:89894329 SPIRE2 0.3 5.8 0.3 1.55e-8 Vitiligo; CRC cis rs870825 0.929 rs871253 chr4:185589234 G/A cg07424746 chr4:185654737 MLF1IP -0.59 -5.7 -0.3 2.61e-8 Blood protein levels; CRC trans rs4942242 0.663 rs7985489 chr13:44206148 T/C cg19169023 chr15:41853346 TYRO3 0.58 8.03 0.4 1.72e-14 Response to tocilizumab in rheumatoid arthritis; CRC cis rs2404602 0.735 rs1607017 chr15:76726465 G/T cg23625390 chr15:77176239 SCAPER -0.83 -12.43 -0.57 2.4e-29 Blood metabolite levels; CRC cis rs7589728 0.844 rs2363010 chr2:88496399 G/C cg24977027 chr2:88469347 THNSL2 0.58 6.54 0.34 2.29e-10 Plasma clusterin levels; CRC cis rs7113874 0.589 rs2044463 chr11:8463951 G/A cg02811074 chr11:8615871 STK33 -0.35 -5.87 -0.31 1.05e-8 Body mass index in physically active individuals;Body mass index (joint analysis main effects and physical activity interaction); CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg05210937 chr4:185655043 MLF1IP 0.44 5.99 0.31 5.41e-9 Anxiety disorder; CRC cis rs10504229 0.683 rs72649188 chr8:58108829 A/G cg02290350 chr8:58132656 NA -0.59 -8.03 -0.4 1.7e-14 Developmental language disorder (linguistic errors); CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg25992645 chr11:65244888 NA 0.47 6.4 0.33 5.22e-10 Anxiety disorder; CRC cis rs6951245 0.872 rs77569514 chr7:1085508 G/A cg20603222 chr7:1096387 C7orf50;GPR146 -0.69 -8.02 -0.4 1.87e-14 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg10717722 chr10:124134020 PLEKHA1 0.42 6.69 0.35 9.67e-11 Liver disease severity in Alagille syndrome; CRC cis rs3892630 0.619 rs61062732 chr19:33304717 T/C cg22980127 chr19:33182716 NUDT19 0.89 12.48 0.57 1.64e-29 Red blood cell traits; CRC cis rs736408 0.562 rs2072390 chr3:52780509 A/T cg18404041 chr3:52824283 ITIH1 -0.4 -8.34 -0.42 2.09e-15 Bipolar disorder; CRC cis rs12188164 0.620 rs56070387 chr5:482531 A/T cg16322479 chr5:444228 EXOC3;C5orf55 0.53 7.55 0.38 4.18e-13 Cystic fibrosis severity; CRC cis rs1552244 0.554 rs2272118 chr3:10049287 T/C cg16606324 chr3:10149918 C3orf24 0.48 7.03 0.36 1.19e-11 Alzheimer's disease; CRC cis rs6831352 0.879 rs36034266 chr4:100061388 T/C cg12011299 chr4:100065546 ADH4 -0.5 -9.53 -0.47 3.48e-19 Alcohol dependence; CRC cis rs2898681 0.519 rs73814886 chr4:53733251 C/T cg00791764 chr4:53727839 RASL11B 0.5 6.68 0.35 1.03e-10 Optic nerve measurement (cup area); CRC trans rs7267979 0.932 rs6132848 chr20:25561645 C/T cg17903999 chr18:56338584 MALT1 -0.43 -7.01 -0.36 1.39e-11 Liver enzyme levels (alkaline phosphatase); CRC trans rs2303319 0.504 rs62189048 chr2:162613494 G/C cg22627826 chr19:1240265 ATP5D -0.72 -6.24 -0.33 1.32e-9 Cognitive function; CRC cis rs10256972 0.591 rs6950319 chr7:1161324 A/G cg23978390 chr7:1156363 C7orf50 0.62 8.71 0.43 1.5e-16 Longevity;Endometriosis; CRC cis rs10504229 0.683 rs61241336 chr8:58106585 A/G cg04204079 chr8:58130323 NA -0.46 -5.79 -0.3 1.67e-8 Developmental language disorder (linguistic errors); CRC cis rs2949837 0.581 rs2960437 chr7:45977352 G/A cg04796162 chr7:45961102 IGFBP3 0.39 6.76 0.35 6.38e-11 Sitting height ratio; CRC cis rs6952808 0.929 rs11761270 chr7:1923695 C/T cg14004847 chr7:1930337 MAD1L1 -0.42 -5.64 -0.3 3.61e-8 Bipolar disorder and schizophrenia; CRC cis rs796364 0.901 rs4673762 chr2:201065171 C/G cg12253985 chr2:200820533 C2orf60;C2orf47 0.57 6.29 0.33 1.03e-9 Schizophrenia; CRC cis rs11212617 0.967 rs227058 chr11:108265213 T/C cg01991180 chr11:108092276 ATM;NPAT 0.44 6.46 0.34 3.73e-10 Response to metformin in type 2 diabetes (glycemic); CRC cis rs17253792 0.822 rs77420254 chr14:56069646 C/T cg01858014 chr14:56050164 KTN1 -0.87 -7.23 -0.37 3.34e-12 Putamen volume; CRC cis rs2836950 0.520 rs59916147 chr21:40634702 T/G cg11644478 chr21:40555479 PSMG1 -0.5 -7.38 -0.38 1.28e-12 Menarche (age at onset); CRC cis rs372883 0.600 rs1153277 chr21:30666867 A/T cg24692254 chr21:30365293 RNF160 -0.65 -9.83 -0.48 3.69e-20 Pancreatic cancer; CRC cis rs7618915 0.571 rs17264436 chr3:52610651 T/A cg18099408 chr3:52552593 STAB1 -0.45 -7.39 -0.38 1.22e-12 Bipolar disorder; CRC cis rs6424115 0.830 rs2502992 chr1:24201919 T/C cg15997130 chr1:24165203 NA 0.73 10.74 0.51 2.79e-23 Immature fraction of reticulocytes; CRC cis rs8180040 0.620 rs6768722 chr3:47079112 G/A cg10298567 chr3:47292165 KIF9 -0.38 -5.96 -0.31 6.55e-9 Colorectal cancer; CRC cis rs9733 0.596 rs72700897 chr1:150626038 C/G cg10589385 chr1:150898437 SETDB1 0.28 5.98 0.31 5.86e-9 Tonsillectomy; CRC cis rs9325144 0.600 rs10785615 chr12:38733627 G/C cg26384229 chr12:38710491 ALG10B 0.56 8.4 0.42 1.38e-15 Morning vs. evening chronotype; CRC trans rs1997103 0.911 rs6945663 chr7:55407011 C/G cg20935933 chr6:143382018 AIG1 0.51 6.65 0.34 1.25e-10 QRS interval (sulfonylurea treatment interaction); CRC cis rs1552244 0.554 rs3732964 chr3:10048839 C/G cg16606324 chr3:10149918 C3orf24 0.48 7.03 0.36 1.19e-11 Alzheimer's disease; CRC cis rs1395 0.744 rs62130714 chr2:27532870 A/G cg14242246 chr2:27434262 C2orf28;SLC5A6 0.35 5.77 0.3 1.84e-8 Blood metabolite levels; CRC cis rs7762018 0.556 rs78233989 chr6:170102041 C/G cg24289452 chr6:170231220 NA -0.83 -7.15 -0.37 5.79e-12 Thiazide-induced adverse metabolic effects in hypertensive patients; CRC cis rs861020 0.604 rs3766612 chr1:210020013 G/T cg05527609 chr1:210001259 C1orf107 -0.96 -12.08 -0.55 4.82e-28 Orofacial clefts; CRC cis rs6545883 0.965 rs6718887 chr2:61727215 G/A cg15711740 chr2:61764176 XPO1 -0.49 -6.86 -0.35 3.51e-11 Tuberculosis; CRC cis rs561341 1.000 rs8069199 chr17:30281845 A/G cg19193384 chr17:30244184 NA -0.53 -6.66 -0.34 1.15e-10 Hip circumference adjusted for BMI; CRC cis rs2304069 0.954 rs2340462 chr5:149415219 G/A cg22760475 chr5:149380129 HMGXB3;TIGD6 0.65 8.21 0.41 5.02e-15 HIV-1 control; CRC cis rs1707322 0.721 rs10890344 chr1:46166090 C/T cg03146154 chr1:46216737 IPP 0.67 9.82 0.48 3.95e-20 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs4481887 0.741 rs28589987 chr1:248564785 T/C cg00666640 chr1:248458726 OR2T12 0.39 6.89 0.36 2.83e-11 Common traits (Other); CRC cis rs17767392 1.000 rs34528013 chr14:71767848 T/C cg13720639 chr14:72061746 SIPA1L1 -0.53 -6.81 -0.35 4.7e-11 Mitral valve prolapse; CRC cis rs926938 0.527 rs7526844 chr1:115543759 T/C cg12756093 chr1:115239321 AMPD1 0.47 6.77 0.35 5.81e-11 Autism; CRC cis rs561341 0.824 rs1978115 chr17:30220776 A/C cg12193833 chr17:30244370 NA -0.62 -7.49 -0.38 6.39e-13 Hip circumference adjusted for BMI; CRC cis rs9733 0.688 rs12725667 chr1:150766070 A/T cg17724175 chr1:150552817 MCL1 -0.38 -5.77 -0.3 1.8e-8 Tonsillectomy; CRC cis rs3771570 0.892 rs62186433 chr2:242257835 A/G cg21155796 chr2:242212141 HDLBP 0.62 6.65 0.34 1.25e-10 Prostate cancer; CRC cis rs11123610 0.520 rs35482526 chr2:3720707 C/G cg25251562 chr2:3704773 ALLC -0.56 -6.72 -0.35 7.81e-11 Response to inhaled corticosteroid treatment in asthma (change in FEV1); CRC cis rs11098499 0.731 rs6846966 chr4:120293208 A/G cg24375607 chr4:120327624 NA 0.49 7.71 0.39 1.49e-13 Corneal astigmatism; CRC cis rs7172677 1.000 rs72730601 chr15:75421720 A/T cg14664628 chr15:75095509 CSK 0.48 5.69 0.3 2.86e-8 Systemic lupus erythematosus and Systemic sclerosis; CRC cis rs2762353 0.595 rs12207270 chr6:25751721 A/G cg03517284 chr6:25882590 NA -0.73 -10.45 -0.5 2.88e-22 Blood metabolite levels; CRC cis rs8077889 1.000 rs59044152 chr17:41888747 A/G cg16892393 chr17:41919603 NA 0.55 7.73 0.39 1.36e-13 Triglycerides; CRC cis rs2839186 0.967 rs4819222 chr21:47707778 G/A cg09417038 chr21:47716443 C21orf57 -0.43 -7.05 -0.36 1.03e-11 Testicular germ cell tumor; CRC cis rs3106136 0.527 rs2865345 chr4:95156565 A/G cg11021082 chr4:95130006 SMARCAD1 -0.58 -9.18 -0.45 4.75e-18 Capecitabine sensitivity; CRC cis rs672059 0.966 rs492228 chr1:183156476 T/C ch.1.3577855R chr1:183094577 LAMC1 0.49 7.13 0.37 6.54e-12 Hypertriglyceridemia; CRC cis rs1218582 0.710 rs4845685 chr1:154878300 C/A cg09359103 chr1:154839909 KCNN3 -0.71 -12.5 -0.57 1.33e-29 Prostate cancer; CRC cis rs1005277 0.540 rs116205409 chr10:38478970 G/A cg25427524 chr10:38739819 LOC399744 -0.77 -13.75 -0.6 2.69e-34 Extrinsic epigenetic age acceleration; CRC cis rs9303280 0.806 rs36038753 chr17:38035370 G/T cg00129232 chr17:37814104 STARD3 -0.43 -6.91 -0.36 2.47e-11 Self-reported allergy; CRC cis rs4908760 0.931 rs1463049 chr1:8597108 A/T cg20416874 chr1:8611966 RERE -0.45 -6.43 -0.33 4.39e-10 Vitiligo; CRC cis rs11077998 0.935 rs9893826 chr17:80511128 C/T cg10255544 chr17:80519551 FOXK2 0.37 5.72 0.3 2.39e-8 Reticulocyte fraction of red cells; CRC cis rs4757319 0.553 rs10766252 chr11:15443714 A/C cg03245590 chr11:15329459 NA 0.51 8.91 0.44 3.61e-17 Breast cancer; CRC cis rs12580194 0.593 rs7959124 chr12:55726957 A/G cg19537932 chr12:55886519 OR6C68 -0.69 -8.71 -0.43 1.49e-16 Cancer; CRC cis rs9368481 0.729 rs9379950 chr6:26961548 T/C cg05192639 chr6:26864778 GUSBL1 -0.37 -6.5 -0.34 3.05e-10 Autism spectrum disorder or schizophrenia; CRC cis rs8008758 1.000 rs8008758 chr14:101690045 A/C cg26224664 chr14:101693935 NA 0.37 5.84 0.31 1.28e-8 Body mass index (alcohol intake interaction); CRC cis rs2658782 0.547 rs3020064 chr11:93060851 A/G cg15737290 chr11:93063684 CCDC67 0.68 10.81 0.51 1.67e-23 Pulmonary function decline; CRC cis rs10504229 1.000 rs6989060 chr8:58178989 T/G cg05313129 chr8:58192883 C8orf71 -0.47 -6.99 -0.36 1.49e-11 Developmental language disorder (linguistic errors); CRC cis rs155076 0.711 rs4770131 chr13:21897468 A/G cg23743428 chr13:21893420 NA -0.42 -6.49 -0.34 3.08e-10 White matter hyperintensity burden; CRC cis rs6754311 0.731 rs7579771 chr2:136580260 T/A cg15123519 chr2:136567270 LCT -0.35 -6.88 -0.35 3.01e-11 Mosquito bite size; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg26084319 chr14:21905280 CHD8 0.52 7.57 0.39 3.76e-13 Response to antipsychotic treatment; CRC cis rs826838 1.000 rs11183469 chr12:38752311 G/A cg13010199 chr12:38710504 ALG10B 0.46 6.02 0.32 4.65e-9 Heart rate; CRC cis rs12893668 0.697 rs67899457 chr14:104060066 A/T cg08213375 chr14:104286397 PPP1R13B 0.35 5.82 0.31 1.4e-8 Reticulocyte count; CRC cis rs12612619 0.732 rs1078809 chr2:27288915 C/T cg00617064 chr2:27272375 NA -0.38 -6.29 -0.33 9.83e-10 Venous thromboembolism adjusted for sickle cell variant rs77121243-T; CRC cis rs10504229 0.683 rs56204590 chr8:58131642 T/G cg05313129 chr8:58192883 C8orf71 -0.43 -6.11 -0.32 2.74e-9 Developmental language disorder (linguistic errors); CRC trans rs6951245 1.000 rs74347384 chr7:1072440 G/A cg13565492 chr6:43139072 SRF -0.71 -7.31 -0.37 2.04e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs9992667 0.911 rs12332031 chr4:38653502 C/T cg19726192 chr4:38663646 FLJ13197 -0.71 -8.93 -0.44 3.18e-17 Eosinophil percentage of granulocytes; CRC cis rs5750830 0.649 rs5750815 chr22:39798449 T/C cg25459000 chr22:39777742 SYNGR1 -0.33 -5.74 -0.3 2.17e-8 Intelligence (multi-trait analysis); CRC cis rs3096299 0.967 rs28644774 chr16:89472181 G/C cg01788221 chr16:89496183 ANKRD11 -0.45 -6.95 -0.36 1.99e-11 Multiple myeloma (IgH translocation); CRC cis rs1403694 0.515 rs1648699 chr3:186449890 G/C cg04611788 chr3:186434169 KNG1 -0.57 -8.32 -0.42 2.41e-15 Blood protein levels; CRC cis rs3820068 0.705 rs2042369 chr1:15843244 A/G cg27534772 chr1:16042836 PLEKHM2 -0.44 -7.53 -0.38 4.8e-13 Systolic blood pressure; CRC cis rs2976388 0.609 rs2717601 chr8:143807924 T/C cg12516270 chr8:143859308 LYNX1 0.44 7.7 0.39 1.5700000000000001e-13 Urinary tract infection frequency; CRC cis rs7937682 0.632 rs11608193 chr11:111732215 T/C cg09085632 chr11:111637200 PPP2R1B 0.95 15.19 0.64 7.34e-40 Primary sclerosing cholangitis; CRC cis rs1448094 0.556 rs11610627 chr12:86167752 C/T cg02569458 chr12:86230093 RASSF9 0.48 8.02 0.4 1.9e-14 Major depressive disorder; CRC trans rs208520 0.690 rs6929762 chr6:66709277 C/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 1.04 14.83 0.63 1.82e-38 Exhaled nitric oxide output; CRC cis rs17376456 0.569 rs896729 chr5:93222178 A/G cg21475434 chr5:93447410 FAM172A -0.48 -5.79 -0.3 1.66e-8 Diabetic retinopathy; CRC cis rs12908161 1.000 rs12905057 chr15:85210765 A/G cg17507749 chr15:85114479 UBE2QP1 0.64 9.03 0.45 1.49e-17 Schizophrenia; CRC cis rs9488822 0.636 rs12201275 chr6:116314563 C/G cg05304507 chr6:116381966 FRK 0.3 8.08 0.41 1.23e-14 Cholesterol, total;LDL cholesterol; CRC cis rs2932538 0.961 rs3013441 chr1:113192605 C/T cg22162597 chr1:113214053 CAPZA1 -0.67 -9.32 -0.46 1.78e-18 Systolic blood pressure;Diastolic blood pressure;Hypertension;Blood pressure; CRC cis rs798554 0.634 rs6978692 chr7:2857411 C/T cg04166393 chr7:2884313 GNA12 0.37 5.69 0.3 2.77e-8 Height; CRC cis rs72781680 0.898 rs72782113 chr2:24024952 G/C cg08917208 chr2:24149416 ATAD2B 0.86 8.58 0.43 3.88e-16 Lymphocyte counts; CRC cis rs6541297 1.000 rs6658942 chr1:230287517 A/C cg20703242 chr1:230279135 GALNT2 0.51 7.89 0.4 4.51e-14 Coronary artery disease; CRC cis rs2836950 0.545 rs2836952 chr21:40616651 G/C cg11890956 chr21:40555474 PSMG1 -0.65 -9.72 -0.47 8.36e-20 Menarche (age at onset); CRC cis rs3733585 0.654 rs4447863 chr4:9938969 T/C cg00071950 chr4:10020882 SLC2A9 -0.63 -11.37 -0.53 1.68e-25 Cleft plate (environmental tobacco smoke interaction); CRC cis rs597539 0.652 rs686390 chr11:68656077 T/C cg04772025 chr11:68637568 NA 0.49 7.21 0.37 3.81e-12 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs1023500 0.505 rs134874 chr22:42661144 A/G cg15557168 chr22:42548783 NA -0.35 -5.93 -0.31 7.59e-9 Schizophrenia; CRC cis rs58688157 0.705 rs12419618 chr11:611531 G/A cg03909863 chr11:638404 DRD4 -0.51 -6.73 -0.35 7.46e-11 Systemic lupus erythematosus; CRC cis rs10504229 0.683 rs11775568 chr8:58133762 G/A cg11062466 chr8:58055876 NA 0.54 6.82 0.35 4.35e-11 Developmental language disorder (linguistic errors); CRC cis rs9926296 0.585 rs1800337 chr16:89845194 A/G cg04287289 chr16:89883240 FANCA 0.83 15.06 0.64 2.31e-39 Vitiligo; CRC cis rs4665809 0.590 rs7260 chr2:26413917 C/T cg26119090 chr2:26468346 HADHA;HADHB -0.96 -13.7 -0.6 4.19e-34 Gut microbiome composition (summer); CRC cis rs7927592 0.913 rs6591344 chr11:68360873 G/A cg16797656 chr11:68205561 LRP5 0.36 5.73 0.3 2.27e-8 Total body bone mineral density; CRC cis rs7590720 1.000 rs4674058 chr2:216909368 A/G cg12620499 chr2:216877984 MREG 0.83 13.12 0.59 6.25e-32 Alcohol dependence; CRC cis rs2046867 0.908 rs62251639 chr3:72801214 G/A cg25664220 chr3:72788482 NA -0.46 -6.39 -0.33 5.8e-10 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; CRC cis rs9858542 1.000 rs2172252 chr3:49678307 A/T cg07274523 chr3:49395745 GPX1 0.48 6.17 0.32 2.05e-9 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs10760158 0.800 rs3747850 chr9:124064928 G/T cg14417974 chr9:124058376 GSN -0.35 -5.74 -0.3 2.18e-8 Pulse pressure; CRC cis rs9381040 0.701 rs4711658 chr6:41162891 C/T cg09580153 chr6:41068724 NFYA;LOC221442 0.42 6.31 0.33 9.18e-10 Alzheimer's disease (late onset); CRC cis rs3806843 0.966 rs11953833 chr5:140155123 T/A cg19875535 chr5:140030758 IK 0.55 8.69 0.43 1.7e-16 Depressive symptoms (multi-trait analysis); CRC cis rs4555082 0.718 rs75139030 chr14:105710853 A/AG cg06808227 chr14:105710500 BRF1 -0.6 -8.58 -0.43 3.77e-16 Mean platelet volume;Platelet distribution width; CRC cis rs4862750 0.832 rs6836426 chr4:187897837 T/G cg11301795 chr4:187892539 NA -0.86 -19.72 -0.74 1.08e-57 Lobe attachment (rater-scored or self-reported); CRC cis rs6840360 0.681 rs4519779 chr4:152301185 G/A cg09659197 chr4:152720779 NA 0.32 6.24 0.33 1.38e-9 Intelligence (multi-trait analysis); CRC cis rs3804749 1.000 rs3804749 chr3:122833003 A/G cg26084141 chr3:122786895 PDIA5 -0.25 -6.88 -0.35 3.1e-11 Plateletcrit;Mean platelet volume;Platelet count;Platelet distribution width; CRC cis rs2290159 0.800 rs6766666 chr3:12690855 A/C cg23032965 chr3:12705835 RAF1 -0.53 -6.59 -0.34 1.76e-10 Cholesterol, total; CRC cis rs2832191 0.692 rs2776240 chr21:30310639 C/T cg08807101 chr21:30365312 RNF160 0.68 10.64 0.51 6.64e-23 Dental caries; CRC cis rs9322193 0.884 rs9480009 chr6:150079638 A/G cg05861140 chr6:150128134 PCMT1 -0.39 -6.26 -0.33 1.21e-9 Lung cancer; CRC cis rs2227564 0.700 rs2688613 chr10:75653045 C/T cg00564723 chr10:75632066 CAMK2G -0.29 -6.68 -0.35 1e-10 Crohn's disease;Inflammatory bowel disease; CRC cis rs9322817 0.691 rs2499658 chr6:105291412 A/G cg02098413 chr6:105308735 HACE1 0.44 8.72 0.43 1.42e-16 Thyroid stimulating hormone; CRC cis rs4713118 0.869 rs2056925 chr6:27690905 A/G cg15845792 chr6:28175446 NA 0.63 8.61 0.43 3.13e-16 Parkinson's disease; CRC cis rs6667605 0.506 rs10797440 chr1:2541269 A/G cg20673091 chr1:2541236 MMEL1 0.36 5.81 0.31 1.48e-8 Inflammatory bowel disease;Ulcerative colitis; CRC cis rs1150688 1 rs1150688 chr6:28162780 T/C cg12273811 chr6:28175739 NA 0.45 6.81 0.35 4.63e-11 Autism spectrum disorder or schizophrenia; CRC cis rs7591163 1.000 rs6738964 chr2:228739135 G/T cg00063174 chr2:228736253 WDR69 -0.52 -7.04 -0.36 1.12e-11 Blood pressure; CRC cis rs12497850 0.931 rs4974085 chr3:48924900 C/T cg20833759 chr3:49053208 WDR6;DALRD3 0.55 9.52 0.46 3.8e-19 Parkinson's disease; CRC cis rs2179367 0.959 rs480034 chr6:149735430 C/T cg11245181 chr6:149772854 ZC3H12D 0.42 6.24 0.33 1.38e-9 Dupuytren's disease; CRC cis rs7224737 1.000 rs2285657 chr17:40272594 C/A cg00647820 chr17:40259828 DHX58 -0.46 -6.5 -0.34 2.97e-10 Fibrinogen levels; CRC cis rs10883723 0.773 rs1326193 chr10:104271674 G/T cg11453585 chr10:104263688 ACTR1A;SUFU 0.9 16.49 0.67 6.2e-45 Allergic disease (asthma, hay fever or eczema); CRC trans rs9858542 0.953 rs4625 chr3:49572140 A/G cg21659725 chr3:3221576 CRBN -0.69 -9.61 -0.47 2.03e-19 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs758324 0.947 rs4705838 chr5:131150593 G/T cg06307176 chr5:131281290 NA 0.43 6.38 0.33 5.98e-10 Alzheimer's disease in APOE e4- carriers; CRC cis rs7662987 0.517 rs1453873 chr4:100022571 T/C cg13256891 chr4:100009986 ADH5 0.63 8.56 0.43 4.54e-16 Smoking initiation; CRC cis rs62408225 0.963 rs55885254 chr6:90976234 T/C cg06866423 chr6:90926672 BACH2 0.5 8.15 0.41 7.56e-15 Eosinophil counts;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC cis rs11190604 1.000 rs10883501 chr10:102238326 A/G cg07080220 chr10:102295463 HIF1AN 0.48 5.79 0.3 1.61e-8 Palmitoleic acid (16:1n-7) levels; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg10901841 chr8:145149865 CYC1 0.41 6.02 0.31 4.62e-9 Anxiety disorder; CRC cis rs832540 0.629 rs6888317 chr5:56093307 A/G cg20203395 chr5:56204925 C5orf35 0.47 6.57 0.34 1.97e-10 Coronary artery disease; CRC cis rs7833986 0.501 rs72653959 chr8:56996516 A/G cg23139584 chr8:56987506 RPS20;SNORD54 0.91 12.39 0.56 3.52e-29 Height; CRC cis rs853679 0.517 rs4713148 chr6:28115921 G/A cg02631126 chr6:28058918 ZSCAN12L1 0.29 5.91 0.31 8.38e-9 Depression; CRC cis rs10504229 0.906 rs7003276 chr8:58173089 A/T cg01721255 chr8:58191610 C8orf71 0.47 6.02 0.31 4.74e-9 Developmental language disorder (linguistic errors); CRC cis rs10486722 0.575 rs7777373 chr7:41804661 T/C cg22138096 chr7:41772439 LOC285954 0.54 6.53 0.34 2.54e-10 Pit-and-Fissure caries; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg18789337 chr6:114180353 MARCKS 0.52 7.0 0.36 1.41e-11 Thyroid stimulating hormone; CRC cis rs2976388 0.565 rs2572905 chr8:143797104 C/T cg05569086 chr8:143859399 LYNX1 0.37 6.58 0.34 1.81e-10 Urinary tract infection frequency; CRC cis rs11969893 0.737 rs1854483 chr6:101378117 G/A cg12253828 chr6:101329408 ASCC3 0.83 6.89 0.35 2.89e-11 Economic and political preferences (immigration/crime); CRC cis rs12477438 0.798 rs2309524 chr2:99659510 A/T cg14399236 chr2:99771627 LIPT1;TSGA10 -0.71 -9.96 -0.48 1.31e-20 Chronic sinus infection; CRC cis rs875971 0.767 rs12668005 chr7:65909021 T/C cg12463550 chr7:65579703 CRCP 0.47 6.3 0.33 9.77e-10 Aortic root size; CRC cis rs4803468 0.967 rs4802116 chr19:41905540 C/T cg09537434 chr19:41945824 ATP5SL -0.93 -18.33 -0.71 3.41e-52 Height; CRC cis rs796364 0.951 rs13029537 chr2:200998950 T/C cg25936922 chr2:200820526 C2orf60;C2orf47 -0.72 -7.76 -0.39 1.1e-13 Schizophrenia; CRC cis rs9322193 0.923 rs9371486 chr6:150153226 T/C cg13206674 chr6:150067644 NUP43 0.69 9.63 0.47 1.62e-19 Lung cancer; CRC cis rs17711722 0.585 rs6942660 chr7:65302406 C/T cg11764359 chr7:65958608 NA 0.52 7.99 0.4 2.34e-14 Calcium levels; CRC cis rs9611565 0.921 rs2235846 chr22:41741042 G/C cg03806693 chr22:41940476 POLR3H -0.66 -9.62 -0.47 1.75e-19 Vitiligo; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg20591167 chr15:99602178 NA 0.42 6.0 0.31 5.13e-9 Response to antipsychotic treatment; CRC cis rs11098499 0.909 rs9759478 chr4:120367998 G/A cg24375607 chr4:120327624 NA 0.53 8.18 0.41 6.27e-15 Corneal astigmatism; CRC cis rs11971779 0.618 rs3778931 chr7:139102490 A/G cg23387468 chr7:139079360 LUC7L2 0.41 7.05 0.36 1.04e-11 Diisocyanate-induced asthma; CRC trans rs10506458 0.915 rs998505 chr12:63400018 C/T cg22491629 chr6:157744540 C6orf35 -0.77 -9.18 -0.45 4.96e-18 Hemostatic factors and hematological phenotypes; CRC cis rs35146811 0.586 rs1076237 chr7:99585441 A/C cg13334819 chr7:99746414 C7orf59 -0.44 -6.0 -0.31 5.32e-9 Coronary artery disease; CRC trans rs8123881 0.733 rs7268466 chr20:15810676 C/T cg02683314 chr19:4182606 SIRT6;ANKRD24 0.53 6.36 0.33 6.59e-10 Body mass index; CRC cis rs6756513 0.520 rs7569566 chr2:70174030 T/C cg02498382 chr2:70120550 SNRNP27 -0.48 -7.9 -0.4 4.32e-14 Breast cancer;Platelet count; CRC cis rs11098499 0.644 rs17517414 chr4:120262101 G/C cg24375607 chr4:120327624 NA 0.47 7.72 0.39 1.42e-13 Corneal astigmatism; CRC cis rs7223966 1.000 rs6504182 chr17:61823672 T/C cg23090583 chr17:61904693 PSMC5;FTSJ3 0.45 5.8 0.3 1.58e-8 Hip circumference adjusted for BMI;Body mass index; CRC cis rs11098499 1.000 rs11098500 chr4:120219239 T/A cg09307838 chr4:120376055 NA 0.65 9.89 0.48 2.29e-20 Corneal astigmatism; CRC cis rs9894429 1.000 rs7503679 chr17:79583843 G/C cg21984481 chr17:79567631 NPLOC4 -0.53 -9.8 -0.48 4.52e-20 Eye color traits; CRC cis rs875971 0.862 rs1167390 chr7:65575893 G/A cg00343986 chr7:65444356 GUSB -0.41 -5.85 -0.31 1.2e-8 Aortic root size; CRC cis rs2976388 0.609 rs2585148 chr8:143796193 C/G cg22687807 chr8:143858763 LYNX1 0.49 8.93 0.44 3.15e-17 Urinary tract infection frequency; CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg19970200 chr7:47621223 NA -0.48 -6.19 -0.32 1.82e-9 Diisocyanate-induced asthma; CRC cis rs9649213 0.593 rs34776142 chr7:97899873 C/T cg21770322 chr7:97807741 LMTK2 0.57 9.43 0.46 7.59e-19 Prostate cancer (SNP x SNP interaction); CRC cis rs3008870 0.677 rs2815354 chr1:67483642 A/T cg08660285 chr1:67390436 MIER1;WDR78 1.02 12.54 0.57 9.57e-30 Lymphocyte percentage of white cells; CRC cis rs2882667 0.931 rs13153618 chr5:138352776 C/A cg09476006 chr5:138032270 NA 0.42 6.91 0.36 2.54e-11 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs11098499 0.866 rs13125526 chr4:120288019 G/A cg24375607 chr4:120327624 NA 0.48 7.48 0.38 6.72e-13 Corneal astigmatism; CRC cis rs853679 0.517 rs4713143 chr6:28106759 A/C cg15845792 chr6:28175446 NA 1.01 13.54 0.6 1.59e-33 Depression; CRC trans rs2797369 0.583 rs7740295 chr6:101549059 T/G cg26346621 chr12:6873348 NA -0.4 -6.01 -0.31 4.93e-9 Renal function-related traits (eGRFcrea); CRC cis rs7542091 0.669 rs11119357 chr1:210042382 C/T cg05527609 chr1:210001259 C1orf107 -0.43 -5.64 -0.3 3.64e-8 Monobrow; CRC cis rs4711350 0.765 rs1318691 chr6:33761884 G/A cg07979401 chr6:33739406 LEMD2 -0.46 -5.99 -0.31 5.37e-9 Schizophrenia; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg26733140 chr11:63993641 NUDT22;TRPT1 0.37 6.91 0.36 2.44e-11 Liver disease severity in Alagille syndrome; CRC cis rs992157 0.767 rs2014615 chr2:219171191 A/G cg00012203 chr2:219082015 ARPC2 0.44 6.63 0.34 1.39e-10 Colorectal cancer; CRC cis rs12477438 0.798 rs6740035 chr2:99576578 C/A cg14399236 chr2:99771627 LIPT1;TSGA10 -0.7 -9.74 -0.47 7.45e-20 Chronic sinus infection; CRC cis rs68170813 0.559 rs7981 chr7:106843133 G/C cg02696742 chr7:106810147 HBP1 -0.6 -6.64 -0.34 1.27e-10 Coronary artery disease; CRC cis rs8031584 0.958 rs34294266 chr15:31246840 A/G cg14829155 chr15:31115871 NA -0.5 -8.03 -0.4 1.8e-14 Huntington's disease progression; CRC cis rs9660992 0.573 rs12125276 chr1:205199440 C/T cg03948781 chr1:205179583 DSTYK 0.41 5.62 0.3 4.02e-8 Mean corpuscular volume;Mean platelet volume; CRC cis rs250677 0.687 rs250664 chr5:148453823 C/T cg18129178 chr5:148520854 ABLIM3 -0.36 -5.61 -0.3 4.38e-8 Breast cancer; CRC cis rs12200560 0.505 rs984520 chr6:97076454 A/G cg06623918 chr6:96969491 KIAA0776 -0.48 -7.12 -0.37 6.74e-12 Coronary heart disease; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg19016253 chr10:101945959 ERLIN1 0.46 6.01 0.31 4.8e-9 Thyroid stimulating hormone; CRC cis rs12477438 0.765 rs10181344 chr2:99692829 C/T cg14399236 chr2:99771627 LIPT1;TSGA10 -0.6 -8.19 -0.41 6.03e-15 Chronic sinus infection; CRC cis rs798554 0.797 rs798486 chr7:2803037 A/G cg19717773 chr7:2847554 GNA12 -0.44 -6.2 -0.32 1.65e-9 Height; CRC cis rs2688608 0.617 rs6480709 chr10:75479125 T/C cg16540259 chr10:75572220 NDST2 0.39 5.88 0.31 9.93e-9 Inflammatory bowel disease; CRC cis rs1448094 0.967 rs7974794 chr12:86323280 A/G cg02569458 chr12:86230093 RASSF9 0.37 6.47 0.34 3.47e-10 Major depressive disorder; CRC cis rs7572644 0.640 rs11127125 chr2:28023120 T/C cg27432699 chr2:27873401 GPN1 0.45 5.66 0.3 3.27e-8 Response to carboplatin and paclitaxel in ovarian cancer (Caspase 3/7 EC50); CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg08190410 chr16:67217759 KIAA0895L 0.46 6.44 0.33 4.32e-10 Anxiety disorder; CRC cis rs765787 0.530 rs1648287 chr15:45516956 T/C cg24006582 chr15:45444508 DUOX1 -0.53 -8.36 -0.42 1.78e-15 Uric acid levels; CRC cis rs66887589 0.592 rs28580295 chr4:120278873 C/T cg09307838 chr4:120376055 NA 0.6 9.33 0.46 1.67e-18 Diastolic blood pressure; CRC cis rs7666738 0.791 rs6833691 chr4:98951508 A/G cg05340658 chr4:99064831 C4orf37 0.61 9.54 0.47 3.45e-19 Colonoscopy-negative controls vs population controls; CRC cis rs10905065 0.895 rs1567706 chr10:5853767 T/C cg11519256 chr10:5708881 ASB13 -0.44 -6.29 -0.33 9.83e-10 Menopause (age at onset); CRC trans rs2303319 0.504 rs12467279 chr2:162544744 A/G cg18122310 chr12:50236657 BCDIN3D -0.73 -6.13 -0.32 2.58e-9 Cognitive function; CRC cis rs1008375 0.966 rs6839660 chr4:17667987 C/T cg16339924 chr4:17578868 LAP3 0.48 6.24 0.33 1.34e-9 Parasitemia in Tripanosoma cruzi seropositivity; CRC trans rs1455244 0.700 rs7229302 chr18:11508904 G/T cg24583646 chr2:75937918 C2orf3 0.39 6.07 0.32 3.54e-9 Schizophrenia; CRC trans rs9291683 0.546 rs4575994 chr4:9997979 G/A cg26043149 chr18:55253948 FECH 0.51 7.79 0.39 8.57e-14 Bone mineral density; CRC cis rs9359856 0.956 rs6933010 chr6:90299879 G/C cg13799429 chr6:90582589 CASP8AP2 0.47 6.61 0.34 1.55e-10 Bipolar disorder; CRC cis rs1552244 0.882 rs2030564 chr3:10039044 A/G cg08888203 chr3:10149979 C3orf24 0.63 8.37 0.42 1.67e-15 Alzheimer's disease; CRC trans rs1728785 1.000 rs1170445 chr16:68573064 G/T cg04657470 chr2:198365150 HSPE1;HSPD1 0.58 6.97 0.36 1.72e-11 Ulcerative colitis; CRC cis rs9910055 0.529 rs183462 chr17:42183376 G/C cg19774624 chr17:42201019 HDAC5 0.5 6.79 0.35 5.11e-11 Total body bone mineral density; CRC cis rs6502050 0.761 rs7225637 chr17:80059758 A/G cg02741985 chr17:80059408 CCDC57 0.42 6.66 0.34 1.12e-10 Life satisfaction; CRC cis rs9462846 1.000 rs2395941 chr6:42867821 G/A cg02353165 chr6:42928485 GNMT 0.55 7.0 0.36 1.44e-11 Blood protein levels; CRC cis rs7487075 0.786 rs2242355 chr12:46662485 C/G cg22049899 chr12:47219821 SLC38A4 0.29 5.63 0.3 3.88e-8 Itch intensity from mosquito bite; CRC cis rs6502050 0.764 rs35713597 chr17:80119016 C/G cg09264619 chr17:80180166 NA -0.35 -5.93 -0.31 7.47e-9 Life satisfaction; CRC cis rs7412746 0.611 rs10888398 chr1:150886782 A/G cg15448220 chr1:150897856 SETDB1 -0.46 -6.75 -0.35 6.5e-11 Melanoma; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg07811750 chr17:4890503 CAMTA2 0.41 6.56 0.34 2.05e-10 Liver disease severity in Alagille syndrome; CRC trans rs9409565 0.826 rs4744338 chr9:97158965 C/T cg05679027 chr9:99775184 HIATL2 0.43 6.65 0.34 1.24e-10 Colorectal cancer (alcohol consumption interaction); CRC cis rs861020 0.606 rs695140 chr1:210005061 G/A cg09163369 chr1:210001066 C1orf107 0.4 5.75 0.3 2.08e-8 Orofacial clefts; CRC cis rs2576037 0.796 rs2247221 chr18:44580082 C/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 -0.45 -7.15 -0.37 5.68e-12 Personality dimensions; CRC cis rs7727544 0.716 rs4705928 chr5:131578637 A/G cg14196790 chr5:131705035 SLC22A5 -0.33 -5.72 -0.3 2.38e-8 Blood metabolite levels; CRC cis rs995000 0.868 rs9787156 chr1:63179212 G/A cg19896129 chr1:63156450 NA -0.43 -6.51 -0.34 2.88e-10 Triglyceride levels; CRC cis rs3768617 0.510 rs20557 chr1:183093875 T/C ch.1.3577855R chr1:183094577 LAMC1 0.89 15.86 0.66 1.84e-42 Fuchs's corneal dystrophy; CRC cis rs477692 1.000 rs522891 chr10:131430916 T/C cg05714579 chr10:131428358 MGMT -0.55 -8.05 -0.41 1.55e-14 Response to temozolomide; CRC cis rs4481887 0.927 rs4381224 chr1:248456826 A/T cg13385794 chr1:248469461 NA 0.38 6.57 0.34 1.94e-10 Common traits (Other); CRC cis rs8060686 0.858 rs8057986 chr16:67893879 A/G cg01951491 chr16:67709440 GFOD2 -0.43 -5.76 -0.3 1.92e-8 HDL cholesterol;Metabolic syndrome; CRC cis rs7811142 1.000 rs67471932 chr7:100009985 C/G cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.18 17.67 0.7 1.31e-49 Platelet count; CRC cis rs1059312 1.000 rs2291350 chr12:129283711 G/A cg09035930 chr12:129282057 SLC15A4 0.53 8.95 0.44 2.57e-17 Systemic lupus erythematosus; CRC cis rs2019216 1.000 rs2019216 chr17:21909650 C/T cg05591447 chr17:21909280 FLJ36000 -0.36 -7.23 -0.37 3.32e-12 Pelvic organ prolapse; CRC cis rs7829975 0.714 rs7823757 chr8:8670177 T/A cg06636001 chr8:8085503 FLJ10661 0.65 10.17 0.49 2.53e-21 Mood instability; CRC cis rs9341808 0.667 rs3805913 chr6:80927322 A/G cg08355045 chr6:80787529 NA 0.37 6.33 0.33 8.12e-10 Sitting height ratio; CRC cis rs6952808 0.594 rs3778964 chr7:2138109 C/T cg22963979 chr7:1858916 MAD1L1 -0.46 -6.63 -0.34 1.36e-10 Bipolar disorder and schizophrenia; CRC cis rs1018836 0.608 rs10094978 chr8:91509054 C/T cg16814680 chr8:91681699 NA -0.57 -8.52 -0.43 5.82e-16 Ejection fraction in Tripanosoma cruzi seropositivity; CRC trans rs11252926 0.931 rs12358336 chr10:566981 A/T cg00953403 chr17:74099816 EXOC7 -0.44 -6.0 -0.31 5.28e-9 Psychosis in Alzheimer's disease; CRC cis rs67478160 0.619 rs28698555 chr14:104316486 C/A cg01849466 chr14:104193079 ZFYVE21 0.47 8.09 0.41 1.14e-14 Schizophrenia; CRC cis rs6890695 1 rs6890695 chr5:130888424 C/G cg06307176 chr5:131281290 NA 0.45 6.51 0.34 2.74e-10 Alzheimer's disease in APOE e4- carriers; CRC cis rs7772486 0.875 rs6570738 chr6:146412695 G/A cg23711669 chr6:146136114 FBXO30 0.6 10.27 0.49 1.18e-21 Lobe attachment (rater-scored or self-reported); CRC cis rs72945132 0.882 rs72947078 chr11:70197542 G/T cg00319359 chr11:70116639 PPFIA1 0.65 6.49 0.34 3.12e-10 Coronary artery disease; CRC cis rs11792861 0.816 rs7021366 chr9:111727670 C/G cg05043794 chr9:111880884 C9orf5 -0.32 -5.67 -0.3 3.14e-8 Menarche (age at onset); CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg05127367 chr3:113234065 CCDC52 0.46 6.31 0.33 8.97e-10 Anxiety disorder; CRC cis rs35362007 0.530 rs17835086 chr14:96012465 A/G cg02940042 chr14:96000874 GLRX5;SNHG10;SCARNA13 0.64 5.75 0.3 2.08e-8 Mean corpuscular volume;Mean corpuscular hemoglobin; CRC cis rs9399137 0.507 rs7745289 chr6:135380327 A/G cg24558204 chr6:135376177 HBS1L 0.6 8.93 0.44 3.13e-17 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; CRC cis rs7917772 0.629 rs1475646 chr10:104522564 G/T cg11453585 chr10:104263688 ACTR1A;SUFU -0.69 -10.28 -0.49 1.15e-21 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC cis rs2806561 1.000 rs1757044 chr1:23515631 T/C cg19743168 chr1:23544995 NA 0.37 5.77 0.3 1.8e-8 Height; CRC cis rs7945705 0.902 rs7930026 chr11:9013639 T/C cg12365402 chr11:9010492 NRIP3 0.52 8.48 0.42 7.59e-16 Hemoglobin concentration; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg12676444 chr3:25825192 NGLY1 0.38 6.12 0.32 2.73e-9 Liver disease severity in Alagille syndrome; CRC cis rs6502050 0.529 rs35585236 chr17:80116641 T/C cg25804541 chr17:80189381 SLC16A3 -0.31 -6.06 -0.32 3.74e-9 Life satisfaction; CRC cis rs11148252 0.774 rs9596649 chr13:52934610 A/G cg12458913 chr13:53173898 NA -0.54 -8.51 -0.42 6.3e-16 Lewy body disease; CRC cis rs7618915 0.547 rs2590846 chr3:52692359 C/G cg08222913 chr3:52553049 STAB1 -0.34 -6.16 -0.32 2.14e-9 Bipolar disorder; CRC cis rs4970988 0.501 rs11204713 chr1:150694623 T/A cg10589385 chr1:150898437 SETDB1 0.28 5.82 0.31 1.38e-8 Urate levels; CRC cis rs56104184 0.723 rs73063515 chr19:49407715 C/T cg21252483 chr19:49399788 TULP2 -0.43 -6.8 -0.35 5.03e-11 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; CRC cis rs2408955 0.522 rs973398 chr12:48491048 A/G cg15465823 chr12:48382534 COL2A1 -0.37 -6.14 -0.32 2.41e-9 Glycated hemoglobin levels; CRC cis rs10971721 0.822 rs12377078 chr9:33934821 A/C cg13495928 chr9:33750294 PRSS3 -0.55 -5.67 -0.3 3.05e-8 Body mass index; CRC cis rs10751667 0.666 rs4072741 chr11:976565 T/C cg01483505 chr11:975446 AP2A2 0.46 7.66 0.39 2.08e-13 Alzheimer's disease (late onset); CRC cis rs2380220 0.541 rs72928273 chr6:96079360 C/T cg23517279 chr6:96025343 MANEA -0.56 -6.2 -0.32 1.64e-9 Behavioural disinhibition (generation interaction); CRC cis rs4853036 0.951 rs10496175 chr2:70153848 A/G cg02498382 chr2:70120550 SNRNP27 -0.42 -5.95 -0.31 6.82e-9 Colorectal or endometrial cancer; CRC cis rs6951245 0.872 rs76713558 chr7:1095866 A/G cg04025307 chr7:1156635 C7orf50 0.63 6.74 0.35 7.02e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs9902453 0.935 rs7220151 chr17:28334710 G/A cg26525008 chr17:28256777 EFCAB5;SSH2 -0.59 -8.78 -0.44 8.99e-17 Coffee consumption (cups per day); CRC cis rs7615952 0.599 rs66532274 chr3:125731845 G/A cg04553112 chr3:125709451 NA -0.47 -6.02 -0.32 4.63e-9 Blood pressure (smoking interaction); CRC cis rs595982 0.527 rs73061659 chr19:49373556 G/A cg15549821 chr19:49342101 PLEKHA4 -0.57 -6.51 -0.34 2.83e-10 Red cell distribution width; CRC cis rs10489202 0.632 rs149912 chr1:167957803 A/T cg24449463 chr1:168025552 DCAF6 -0.61 -9.09 -0.45 9.79e-18 Schizophrenia; CRC cis rs34375054 0.558 rs12578774 chr12:125681761 A/G cg05341575 chr12:125625032 AACS 0.37 5.78 0.3 1.7e-8 Post bronchodilator FEV1/FVC ratio; CRC cis rs1788820 0.717 rs1788823 chr18:21114917 A/G cg14672496 chr18:21087552 C18orf8 0.44 7.46 0.38 8e-13 Body mass index; CRC cis rs3824867 0.804 rs12419342 chr11:47468545 C/T cg05585544 chr11:47624801 NA -0.39 -6.06 -0.32 3.69e-9 Mean corpuscular hemoglobin; CRC cis rs9302635 0.513 rs8061282 chr16:72155938 C/T cg23815491 chr16:72088622 HP 0.57 7.32 0.37 1.9e-12 Blood protein levels; CRC cis rs7659604 0.605 rs1396080 chr4:122740454 T/G cg19748678 chr4:122722346 EXOSC9 0.59 9.39 0.46 1.04e-18 Type 2 diabetes; CRC cis rs7927771 1.000 rs12787330 chr11:47812311 C/T cg20307385 chr11:47447363 PSMC3 -0.49 -6.56 -0.34 2.04e-10 Subjective well-being; CRC cis rs2239547 0.522 rs9865094 chr3:52985319 G/C cg18404041 chr3:52824283 ITIH1 0.33 6.6 0.34 1.66e-10 Schizophrenia; CRC cis rs1552244 1.000 rs9845756 chr3:10067548 G/C cg10729496 chr3:10149963 C3orf24 0.5 6.64 0.34 1.28e-10 Alzheimer's disease; CRC cis rs11655198 1 rs11655198 chr17:38026169 C/T cg20243544 chr17:37824526 PNMT 0.42 6.6 0.34 1.69e-10 Asthma; CRC cis rs780096 0.546 rs2911712 chr2:27626945 A/T cg02592271 chr2:27665507 KRTCAP3 -0.27 -6.23 -0.32 1.44e-9 Total body bone mineral density; CRC cis rs3741404 0.609 rs666497 chr11:63869821 G/C cg05016508 chr11:63871570 FLRT1;MACROD1 0.53 8.88 0.44 4.37e-17 Platelet count; CRC cis rs9491140 0.539 rs11154224 chr6:124678535 G/A cg22366943 chr6:124882293 NKAIN2 0.56 8.52 0.43 5.69e-16 Neuroticism; CRC cis rs4713118 0.739 rs2893931 chr6:27748010 G/A cg12172441 chr6:28176163 NA 0.54 7.07 0.36 9.53e-12 Parkinson's disease; CRC cis rs9303401 0.580 rs12603808 chr17:56578508 T/G cg02118635 chr17:56770003 RAD51C;TEX14 0.81 9.44 0.46 6.98e-19 Cognitive test performance; CRC trans rs561341 1.000 rs530715 chr17:30320544 T/G cg27661571 chr11:113659931 NA -0.76 -9.53 -0.47 3.57e-19 Hip circumference adjusted for BMI; CRC cis rs765787 0.530 rs12323957 chr15:45490773 C/T cg24006582 chr15:45444508 DUOX1 0.55 7.92 0.4 3.81e-14 Uric acid levels; CRC cis rs6502050 0.835 rs4789676 chr17:80123078 C/T cg22110888 chr17:80059540 CCDC57 0.4 6.38 0.33 5.96e-10 Life satisfaction; CRC cis rs938554 0.542 rs7678287 chr4:10000501 A/G cg00071950 chr4:10020882 SLC2A9 0.48 6.66 0.34 1.13e-10 Blood metabolite levels; CRC cis rs739401 0.619 rs10766480 chr11:2961325 G/A cg08508325 chr11:3079039 CARS -0.41 -7.15 -0.37 5.52e-12 Longevity; CRC cis rs9341808 0.621 rs2322627 chr6:80806341 T/A cg08355045 chr6:80787529 NA 0.45 7.3 0.37 2.2e-12 Sitting height ratio; CRC cis rs801193 0.660 rs1962050 chr7:66240008 C/T cg11764359 chr7:65958608 NA -0.58 -9.0 -0.44 1.87e-17 Aortic root size; CRC cis rs832540 0.801 rs7731700 chr5:56111927 C/T cg20203395 chr5:56204925 C5orf35 -0.42 -5.73 -0.3 2.27e-8 Coronary artery disease; CRC cis rs9633740 1.000 rs7097656 chr10:82250831 T/C cg00277334 chr10:82204260 NA -0.52 -5.68 -0.3 2.98e-8 Post bronchodilator FEV1; CRC trans rs7613875 0.600 rs1138536 chr3:50153356 C/T cg21665057 chr3:196295764 WDR53;FBXO45 0.45 6.45 0.34 4.04e-10 Body mass index; CRC cis rs9325144 0.555 rs7955128 chr12:38684121 A/T cg26384229 chr12:38710491 ALG10B 0.56 8.12 0.41 9.72e-15 Morning vs. evening chronotype; CRC cis rs7113874 0.531 rs7934396 chr11:8615632 C/G cg02811074 chr11:8615871 STK33 0.35 6.05 0.32 3.93e-9 Body mass index in physically active individuals;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs2576037 0.526 rs3892820 chr18:44479558 A/G cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.67 -11.01 -0.52 3.19e-24 Personality dimensions; CRC cis rs1005277 0.603 rs1998062 chr10:38457652 G/C cg25517755 chr10:38738941 LOC399744 -0.43 -6.3 -0.33 9.65e-10 Extrinsic epigenetic age acceleration; CRC cis rs6570726 0.967 rs9403707 chr6:145800010 A/G cg23711669 chr6:146136114 FBXO30 0.68 11.89 0.55 2.24e-27 Lobe attachment (rater-scored or self-reported); CRC cis rs3820068 0.581 rs72645879 chr1:15928199 A/G cg13390004 chr1:15929781 NA 0.51 7.2 0.37 4.22e-12 Systolic blood pressure; CRC cis rs727505 0.866 rs3214004 chr7:124720929 T/C cg23710748 chr7:124431027 NA -0.72 -12.33 -0.56 5.81e-29 Lewy body disease; CRC cis rs875971 1.000 rs1544549 chr7:66090663 T/A cg00343986 chr7:65444356 GUSB -0.45 -6.49 -0.34 3.19e-10 Aortic root size; CRC cis rs4285028 0.948 rs7651226 chr3:121670802 G/T cg11130432 chr3:121712080 ILDR1 -0.52 -6.75 -0.35 6.81e-11 Multiple sclerosis; CRC cis rs734999 0.545 rs28568531 chr1:2555640 T/A cg18854424 chr1:2615690 NA 0.4 7.69 0.39 1.72e-13 Ulcerative colitis; CRC cis rs10504229 0.679 rs11783444 chr8:58131267 A/G cg24829409 chr8:58192753 C8orf71 -0.55 -8.03 -0.4 1.71e-14 Developmental language disorder (linguistic errors); CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg02698600 chr1:201450009 NA -0.39 -6.0 -0.31 5.1e-9 Myopia (pathological); CRC cis rs6952808 1.000 rs4719319 chr7:1888094 G/A cg20295408 chr7:1910781 MAD1L1 -0.45 -6.25 -0.33 1.31e-9 Bipolar disorder and schizophrenia; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg27479418 chr10:126107594 OAT 0.37 6.1 0.32 3.05e-9 Liver disease severity in Alagille syndrome; CRC cis rs1448094 0.512 rs7970842 chr12:86243258 C/T cg25456477 chr12:86230367 RASSF9 0.33 5.69 0.3 2.81e-8 Major depressive disorder; CRC cis rs2839186 0.771 rs2280959 chr21:47641996 C/G cg13126279 chr21:47581558 C21orf56 -0.52 -8.51 -0.42 6.27e-16 Testicular germ cell tumor; CRC cis rs10504229 0.683 rs1495865 chr8:58141160 T/G cg24829409 chr8:58192753 C8orf71 -0.55 -8.03 -0.4 1.71e-14 Developmental language disorder (linguistic errors); CRC trans rs916888 0.821 rs199507 chr17:44858855 A/G cg23590916 chr17:43697445 MGC57346 -0.57 -6.14 -0.32 2.32e-9 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs896854 0.625 rs13281709 chr8:95972819 T/A cg09323728 chr8:95962352 TP53INP1 -0.45 -7.45 -0.38 8.06e-13 Type 2 diabetes; CRC cis rs2842992 0.830 rs2842974 chr6:160159034 C/T cg11366901 chr6:160182831 ACAT2 0.96 13.99 0.61 3.33e-35 Age-related macular degeneration (geographic atrophy); CRC cis rs9399135 0.904 rs4895438 chr6:135317665 G/T cg22676075 chr6:135203613 NA 0.41 6.35 0.33 7.3e-10 Red blood cell count; CRC cis rs739401 0.611 rs10833048 chr11:3020040 A/G cg05729581 chr11:3078854 CARS -0.58 -8.61 -0.43 3.09e-16 Longevity; CRC cis rs7493 1.000 rs3735586 chr7:95035582 A/T cg07404485 chr7:94953653 PON1 -0.45 -6.04 -0.32 4.16e-9 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs1552244 0.832 rs61056817 chr3:10027641 C/T cg02579736 chr3:10068473 FANCD2;CIDECP 0.9 10.58 0.5 1.07e-22 Alzheimer's disease; CRC cis rs1448094 0.512 rs11832992 chr12:86240790 T/C cg00310523 chr12:86230176 RASSF9 0.34 5.79 0.3 1.67e-8 Major depressive disorder; CRC cis rs7255436 0.965 rs7351098 chr19:8451671 G/C cg16745616 chr19:8428856 ANGPTL4 -0.45 -7.04 -0.36 1.16e-11 HDL cholesterol; CRC cis rs919433 0.680 rs2565161 chr2:198285554 C/G cg10820045 chr2:198174542 NA 0.39 6.41 0.33 4.94e-10 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC trans rs9329221 0.698 rs12547997 chr8:10260837 A/G cg08975724 chr8:8085496 FLJ10661 0.38 5.98 0.31 5.97e-9 Neuroticism; CRC cis rs9549260 0.755 rs2151785 chr13:41243660 G/A cg21288729 chr13:41239152 FOXO1 0.5 7.76 0.39 1.08e-13 Red blood cell count; CRC cis rs4684776 0.676 rs1809049 chr3:11302884 C/T cg00170343 chr3:11313890 ATG7 -0.47 -5.62 -0.3 4.08e-8 Small vessel stroke; CRC cis rs9462846 0.853 rs7741547 chr6:42873813 A/G cg21280719 chr6:42927975 GNMT -0.33 -6.43 -0.33 4.47e-10 Blood protein levels; CRC cis rs514406 0.505 rs374849 chr1:53185631 G/A cg25767906 chr1:53392781 SCP2 -0.38 -5.93 -0.31 7.8e-9 Monocyte count; CRC cis rs1862618 0.853 rs252915 chr5:56121754 C/T cg24531977 chr5:56204891 C5orf35 0.75 10.35 0.5 6.58e-22 Initial pursuit acceleration; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg27252137 chr12:124155579 TCTN2 0.42 6.01 0.31 4.82e-9 Intelligence (multi-trait analysis); CRC cis rs9400271 0.632 rs9374071 chr6:109588681 T/C cg01475377 chr6:109611718 NA -0.35 -6.09 -0.32 3.18e-9 Sum neutrophil eosinophil counts;Sum basophil neutrophil counts;White blood cell count;Neutrophil count;Myeloid white cell count;Granulocyte count; CRC cis rs2204008 0.870 rs12369578 chr12:38444227 C/T cg13010199 chr12:38710504 ALG10B 0.47 6.09 0.32 3.16e-9 Bladder cancer; CRC cis rs1348850 0.567 rs880899 chr2:178532416 A/G cg22681709 chr2:178499509 PDE11A -0.44 -8.12 -0.41 9.51e-15 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs11227306 0.934 rs11227313 chr11:65588938 C/T cg26695010 chr11:65641043 EFEMP2 -0.48 -6.45 -0.33 4.04e-10 DNA methylation (variation); CRC cis rs7917772 0.628 rs4604806 chr10:104373904 G/A cg11453585 chr10:104263688 ACTR1A;SUFU 0.82 15.13 0.64 1.23e-39 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC cis rs9902453 0.845 rs72823935 chr17:28008595 C/T cg26525008 chr17:28256777 EFCAB5;SSH2 0.6 9.03 0.45 1.46e-17 Coffee consumption (cups per day); CRC cis rs11792861 0.926 rs7855282 chr9:111802614 T/A cg05043794 chr9:111880884 C9orf5 -0.35 -6.43 -0.33 4.4e-10 Menarche (age at onset); CRC cis rs7246657 0.882 rs8112610 chr19:37928730 C/A cg23950597 chr19:37808831 NA -0.49 -6.09 -0.32 3.18e-9 Coronary artery calcification; CRC cis rs9486719 1.000 rs11153023 chr6:96968525 C/T cg06623918 chr6:96969491 KIAA0776 -0.8 -9.14 -0.45 6.38e-18 Migraine;Coronary artery disease; CRC cis rs7274811 0.711 rs657040 chr20:32001292 A/G cg07470512 chr20:32255052 NECAB3;C20orf134 0.43 5.89 0.31 9.59e-9 Height; CRC cis rs12024301 0.557 rs9286849 chr1:183655210 C/T cg11505048 chr1:183622726 RGL1;APOBEC4 0.62 5.61 0.3 4.28e-8 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs709400 0.894 rs10143293 chr14:104063014 G/A cg08213375 chr14:104286397 PPP1R13B -0.35 -5.75 -0.3 1.99e-8 Body mass index; CRC cis rs72627123 0.867 rs57685514 chr14:74487592 A/G cg12022184 chr14:74485813 ENTPD5;C14orf45 0.71 5.81 0.3 1.5e-8 Morning vs. evening chronotype; CRC cis rs921968 0.678 rs660432 chr2:219432127 C/T cg02176678 chr2:219576539 TTLL4 0.48 7.88 0.4 4.94e-14 Mean corpuscular hemoglobin concentration; CRC cis rs4409675 0.576 rs2078328 chr1:28224976 A/G cg23691781 chr1:28212827 C1orf38 0.31 7.14 0.37 5.87e-12 Corneal astigmatism; CRC cis rs3736485 0.934 rs12442803 chr15:51898754 C/G cg08986416 chr15:51914746 DMXL2 -0.45 -6.5 -0.34 3.02e-10 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg24516711 chr2:242576858 ATG4B;THAP4 0.47 6.63 0.34 1.4e-10 Anxiety disorder; CRC trans rs2553218 0.690 rs8032415 chr15:54851945 A/G cg20310071 chr8:77912528 PXMP3 0.45 5.99 0.31 5.43e-9 Immune response to smallpox vaccine (IL-6); CRC cis rs9326248 0.861 rs4938352 chr11:117027481 G/A cg11861562 chr11:117069780 TAGLN 0.34 6.26 0.33 1.19e-9 Blood protein levels; CRC cis rs9733 0.503 rs7556451 chr1:150913142 A/G cg10589385 chr1:150898437 SETDB1 0.27 5.92 0.31 7.89e-9 Tonsillectomy; CRC cis rs7760949 0.889 rs9475787 chr6:13926102 G/C cg27413430 chr6:13925136 RNF182 0.33 5.75 0.3 2.03e-8 Mean corpuscular hemoglobin concentration; CRC cis rs360798 0.532 rs1553832 chr2:63013515 C/G cg17519650 chr2:63277830 OTX1 -0.44 -6.2 -0.32 1.68e-9 Coronary artery disease; CRC cis rs1008375 1.000 rs3846357 chr4:17635887 A/T cg04450456 chr4:17643702 FAM184B 0.41 6.69 0.35 9.77e-11 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs6938 0.618 rs12911254 chr15:75166335 G/A cg09165964 chr15:75287851 SCAMP5 0.55 8.76 0.43 1.08e-16 Breast cancer; CRC trans rs7647973 0.593 rs59684465 chr3:49874246 C/T cg21665057 chr3:196295764 WDR53;FBXO45 0.64 7.11 0.36 7.11e-12 Menarche (age at onset); CRC cis rs853679 0.517 rs35512245 chr6:28079953 T/C cg21251018 chr6:28226885 NKAPL 0.48 6.22 0.32 1.48e-9 Depression; CRC cis rs2811415 0.597 rs9861755 chr3:127739721 A/G cg13719885 chr3:127795394 NA -0.37 -5.72 -0.3 2.37e-8 Lung function (FEV1/FVC); CRC cis rs6502050 0.835 rs8067138 chr17:80111026 T/C cg02741985 chr17:80059408 CCDC57 0.43 7.15 0.37 5.66e-12 Life satisfaction; CRC cis rs10256972 0.684 rs4724039 chr7:1111633 A/G cg16145915 chr7:1198662 ZFAND2A -0.3 -5.84 -0.31 1.25e-8 Longevity;Endometriosis; CRC cis rs7591163 1.000 rs6738964 chr2:228739135 G/T cg14646075 chr2:228736089 WDR69 -0.47 -6.42 -0.33 4.82e-10 Blood pressure; CRC cis rs1403694 0.695 rs1050274 chr3:186435370 G/A cg04611788 chr3:186434169 KNG1 -0.61 -9.13 -0.45 7.33e-18 Blood protein levels; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg02664216 chr12:19592651 AEBP2 0.52 6.91 0.36 2.53e-11 Thyroid stimulating hormone; CRC cis rs2732480 0.500 rs12828309 chr12:48641160 C/T cg21466736 chr12:48725269 NA -0.53 -7.95 -0.4 3.09e-14 Hemoglobin concentration;Red blood cell count;Hematocrit; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg24796471 chr19:6737389 GPR108 0.46 6.96 0.36 1.8e-11 Intelligence (multi-trait analysis); CRC cis rs6502050 0.799 rs11491185 chr17:80151101 C/T cg09264619 chr17:80180166 NA -0.37 -6.17 -0.32 2.04e-9 Life satisfaction; CRC trans rs10506458 0.834 rs12426860 chr12:63387948 C/T cg22491629 chr6:157744540 C6orf35 -0.73 -8.33 -0.42 2.18e-15 Hemostatic factors and hematological phenotypes; CRC cis rs12701220 0.894 rs12539012 chr7:1052133 G/A cg00990874 chr7:1149470 C7orf50 -0.58 -6.75 -0.35 6.74e-11 Bronchopulmonary dysplasia; CRC cis rs4689388 0.853 rs11729672 chr4:6293838 A/G cg25554036 chr4:6271136 WFS1 0.54 8.73 0.43 1.29e-16 Type 2 diabetes and other traits;Type 2 diabetes; CRC cis rs7666738 0.830 rs4492007 chr4:98959848 A/T cg17366294 chr4:99064904 C4orf37 0.43 7.34 0.38 1.69e-12 Colonoscopy-negative controls vs population controls; CRC cis rs8031584 0.958 rs1043742 chr15:31232581 A/C cg14829155 chr15:31115871 NA -0.48 -7.81 -0.4 7.54e-14 Huntington's disease progression; CRC cis rs6076065 0.723 rs2281429 chr20:23399544 A/T cg11657817 chr20:23433608 CST11 0.4 6.21 0.32 1.6e-9 Facial morphology (factor 15, philtrum width); CRC cis rs9486719 1.000 rs2472890 chr6:96867646 C/T cg06623918 chr6:96969491 KIAA0776 0.81 9.48 0.46 5.18e-19 Migraine;Coronary artery disease; CRC cis rs10883723 0.810 rs12162 chr10:104240498 A/G cg11453585 chr10:104263688 ACTR1A;SUFU 0.68 9.3 0.46 1.95e-18 Allergic disease (asthma, hay fever or eczema); CRC cis rs2836950 0.520 rs8130240 chr21:40538108 G/A cg11644478 chr21:40555479 PSMG1 -0.52 -7.97 -0.4 2.67e-14 Menarche (age at onset); CRC cis rs12144094 0.882 rs1853048 chr1:120240114 C/A cg20995928 chr1:120229863 NA 0.48 6.9 0.36 2.74e-11 Height; CRC cis rs1799949 1.000 rs4793194 chr17:41218333 G/A cg05368731 chr17:41323189 NBR1 0.68 10.14 0.49 3.26e-21 Menopause (age at onset); CRC cis rs4731207 0.698 rs10272583 chr7:124509451 T/C cg23710748 chr7:124431027 NA -0.38 -6.08 -0.32 3.42e-9 Cutaneous malignant melanoma; CRC cis rs7072216 0.655 rs3830025 chr10:100176104 A/G cg26618903 chr10:100175079 PYROXD2 -0.52 -8.24 -0.41 4.22e-15 Metabolite levels; CRC trans rs2303319 0.504 rs62187609 chr2:162431500 C/T cg22677401 chr17:46026860 NA -0.7 -6.05 -0.32 3.89e-9 Cognitive function; CRC cis rs9768139 0.901 rs56113702 chr7:158117938 C/T cg06219351 chr7:158114137 PTPRN2 0.44 6.64 0.34 1.29e-10 Calcium levels; CRC cis rs926938 0.618 rs360587 chr1:115467553 A/G cg12756093 chr1:115239321 AMPD1 0.57 8.69 0.43 1.74e-16 Autism; CRC trans rs875971 0.660 rs2191268 chr7:66110224 C/T cg20505218 chr17:80009845 GPS1;RFNG -0.41 -6.24 -0.33 1.34e-9 Aortic root size; CRC cis rs4474465 1.000 rs11604969 chr11:78179293 C/T cg27205649 chr11:78285834 NARS2 0.48 5.85 0.31 1.2e-8 Alzheimer's disease (survival time); CRC cis rs10504229 0.728 rs72650867 chr8:58154912 C/T cg02290350 chr8:58132656 NA -0.51 -6.57 -0.34 1.98e-10 Developmental language disorder (linguistic errors); CRC cis rs1799949 1.000 rs12936816 chr17:41301709 C/T cg23758822 chr17:41437982 NA 0.79 13.45 0.6 3.6e-33 Menopause (age at onset); CRC cis rs1799949 1.000 rs33946455 chr17:41321846 C/T cg23758822 chr17:41437982 NA 0.8 13.61 0.6 9.07e-34 Menopause (age at onset); CRC cis rs7605378 1.000 rs769954 chr2:200692159 C/G cg23649088 chr2:200775458 C2orf69 -0.56 -7.9 -0.4 4.36e-14 Osteoporosis; CRC trans rs10982213 0.830 rs2274163 chr9:117188714 C/T cg17684478 chr11:118842230 FOXR1 0.43 6.82 0.35 4.26e-11 Interleukin-6 levels; CRC cis rs6691722 0.503 rs2274168 chr1:24707211 G/T cg02336364 chr1:24764700 NIPAL3 0.38 6.34 0.33 7.53e-10 Response to interferon beta in multiple sclerosis; CRC cis rs6479527 0.875 rs7033898 chr9:96804235 T/C cg14459158 chr9:96720562 NA 0.39 6.95 0.36 1.96e-11 Esophageal adenocarcinoma; CRC cis rs9811920 0.695 rs1287284 chr3:99516962 C/A cg07805332 chr3:99536008 MIR548G;C3orf26 0.4 6.21 0.32 1.63e-9 Axial length; CRC cis rs6952808 0.792 rs2056481 chr7:1955435 A/G cg20295408 chr7:1910781 MAD1L1 -0.43 -5.97 -0.31 6.12e-9 Bipolar disorder and schizophrenia; CRC cis rs8072100 0.581 rs4267364 chr17:45781264 A/G cg08085267 chr17:45401833 C17orf57 -0.39 -5.74 -0.3 2.17e-8 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs10504229 0.906 rs114627636 chr8:58173732 C/T cg22535103 chr8:58192502 C8orf71 -0.83 -8.92 -0.44 3.31e-17 Developmental language disorder (linguistic errors); CRC cis rs875971 0.964 rs11765965 chr7:65842221 A/G cg11764359 chr7:65958608 NA 0.61 9.95 0.48 1.41e-20 Aortic root size; CRC cis rs7772486 0.654 rs6928007 chr6:146074941 G/A cg23711669 chr6:146136114 FBXO30 -0.65 -10.71 -0.51 3.75e-23 Lobe attachment (rater-scored or self-reported); CRC cis rs10504229 0.683 rs11784908 chr8:58131472 T/C cg04204079 chr8:58130323 NA -0.45 -5.78 -0.3 1.71e-8 Developmental language disorder (linguistic errors); CRC cis rs11229555 0.609 rs7928676 chr11:58188022 C/T cg15696309 chr11:58395628 NA -0.82 -10.31 -0.49 8.59e-22 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; CRC cis rs2032447 0.670 rs198848 chr6:26106325 A/G cg18357526 chr6:26021779 HIST1H4A 0.68 10.25 0.49 1.45e-21 Intelligence (multi-trait analysis); CRC cis rs67311347 1.000 rs962847 chr3:40495156 A/G cg09455208 chr3:40491958 NA -0.43 -8.69 -0.43 1.74e-16 Renal cell carcinoma; CRC cis rs7833790 0.929 rs28464834 chr8:82797356 A/T cg17211192 chr8:82754475 SNX16 0.55 6.62 0.34 1.49e-10 Diastolic blood pressure; CRC cis rs929354 0.742 rs1182396 chr7:157031831 A/C cg16102536 chr7:156981717 UBE3C -0.41 -6.85 -0.35 3.58e-11 Body mass index; CRC cis rs7914558 1.000 rs10883837 chr10:104896486 G/A cg04362960 chr10:104952993 NT5C2 0.59 8.75 0.43 1.14e-16 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg02933969 chr8:12612811 LONRF1 0.47 6.46 0.34 3.83e-10 Anxiety disorder; CRC trans rs615632 0.530 rs10092464 chr8:9804185 C/G cg06636001 chr8:8085503 FLJ10661 -0.5 -6.78 -0.35 5.43e-11 Neuroticism; CRC cis rs644148 0.730 rs2686766 chr19:44991595 T/G cg15540054 chr19:45004280 ZNF180 -0.54 -6.77 -0.35 6e-11 Personality dimensions; CRC trans rs61931739 0.500 rs7312938 chr12:34378708 C/T cg26384229 chr12:38710491 ALG10B 0.67 8.94 0.44 2.93e-17 Morning vs. evening chronotype; CRC cis rs13191362 0.938 rs35760705 chr6:163020637 G/A cg23758597 chr6:163146217 PARK2 -0.52 -6.08 -0.32 3.36e-9 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs6662572 0.703 rs56278140 chr1:46357544 G/A cg03123370 chr1:45965343 CCDC163P;MMACHC 0.45 5.71 0.3 2.46e-8 Blood protein levels; CRC cis rs2050392 0.517 rs687036 chr10:30761249 G/A cg18806716 chr10:30721971 MAP3K8 -0.57 -8.08 -0.41 1.23e-14 Inflammatory bowel disease; CRC cis rs9747201 0.962 rs6502062 chr17:80086177 T/G cg14673194 chr17:80132900 CCDC57 0.48 6.27 0.33 1.13e-9 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs71403859 0.730 rs12923781 chr16:71653464 G/A cg08717414 chr16:71523259 ZNF19 -1.03 -9.73 -0.47 8.1e-20 Post bronchodilator FEV1; CRC cis rs4731207 0.596 rs6954614 chr7:124629794 G/A cg23710748 chr7:124431027 NA -0.4 -6.33 -0.33 7.94e-10 Cutaneous malignant melanoma; CRC cis rs6502050 0.777 rs4625783 chr17:80086395 T/C cg02741985 chr17:80059408 CCDC57 -0.44 -7.15 -0.37 5.59e-12 Life satisfaction; CRC cis rs9549367 0.713 rs3024747 chr13:113821787 C/G cg24300038 chr13:113819356 PROZ -0.47 -6.03 -0.32 4.5e-9 Platelet distribution width; CRC cis rs10504073 0.605 rs62507176 chr8:49930321 G/A cg00325661 chr8:49890786 NA 0.64 11.52 0.54 5.1e-26 Blood metabolite ratios; CRC cis rs72634258 0.945 rs2294889 chr1:8075934 A/G cg26816564 chr1:7831052 VAMP3 0.51 5.78 0.3 1.74e-8 Inflammatory bowel disease; CRC cis rs933688 1.000 rs1035476 chr5:90745976 C/T cg26981201 chr5:90679533 LOC100129716;ARRDC3 0.99 15.14 0.64 1.16e-39 Smoking behavior; CRC cis rs8180040 0.620 rs11707736 chr3:47069504 G/T cg27129171 chr3:47204927 SETD2 -0.73 -11.56 -0.54 3.63e-26 Colorectal cancer; CRC cis rs2735413 0.709 rs9938043 chr16:78091426 A/G cg04733911 chr16:78082701 NA -0.41 -6.55 -0.34 2.19e-10 Systolic blood pressure (alcohol consumption interaction); CRC cis rs3806843 0.933 rs2240696 chr5:140168070 A/G cg16607685 chr5:140181889 PCDHA2;PCDHA1;PCDHA3 -0.26 -5.92 -0.31 8.09e-9 Depressive symptoms (multi-trait analysis); CRC cis rs9814567 1.000 rs1874883 chr3:134205071 G/T cg06541857 chr3:134203789 ANAPC13;CEP63 -0.42 -6.45 -0.34 3.97e-10 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs9992667 0.955 rs66709517 chr4:38649393 A/G cg19726192 chr4:38663646 FLJ13197 -0.69 -8.69 -0.43 1.72e-16 Eosinophil percentage of granulocytes; CRC cis rs9649213 0.593 rs12704983 chr7:97927045 G/A cg21770322 chr7:97807741 LMTK2 0.51 8.46 0.42 9.08e-16 Prostate cancer (SNP x SNP interaction); CRC cis rs6570726 0.791 rs443628 chr6:145883484 T/C cg05347473 chr6:146136440 FBXO30 0.4 6.06 0.32 3.7e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs7923609 0.967 rs10740134 chr10:65315433 T/C cg08743896 chr10:65200160 JMJD1C -0.4 -5.72 -0.3 2.42e-8 Educational attainment;Liver enzyme levels (alkaline phosphatase); CRC cis rs4076764 0.535 rs4409627 chr1:163382050 A/G cg06092702 chr1:163392909 NA 0.39 6.02 0.31 4.66e-9 Motion sickness; CRC cis rs10089 1.000 rs4836366 chr5:127482494 A/T cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.75 10.55 0.5 1.3e-22 Ileal carcinoids; CRC cis rs250677 0.687 rs36048 chr5:148441713 G/C cg23229984 chr5:148520753 ABLIM3 0.49 6.8 0.35 4.85e-11 Breast cancer; CRC cis rs13118159 0.778 rs12650998 chr4:1338832 T/C cg21620606 chr4:1342894 KIAA1530 0.4 7.19 0.37 4.39e-12 Longevity; CRC cis rs881375 0.678 rs7031752 chr9:123663482 G/T cg14255062 chr9:123606675 PSMD5;LOC253039 0.4 6.3 0.33 9.81e-10 Rheumatoid arthritis; CRC cis rs6840360 1.000 rs4696291 chr4:152631637 G/A cg09659197 chr4:152720779 NA 0.52 11.25 0.53 4.71e-25 Intelligence (multi-trait analysis); CRC cis rs11098499 0.954 rs10518331 chr4:120323595 C/T cg24375607 chr4:120327624 NA 0.51 7.98 0.4 2.49e-14 Corneal astigmatism; CRC cis rs11155671 0.530 rs7756850 chr6:150212596 G/C cg13206674 chr6:150067644 NUP43 0.5 6.93 0.36 2.24e-11 Testicular germ cell tumor; CRC cis rs2228479 0.702 rs11076621 chr16:89837927 A/G cg19635926 chr16:89946313 TCF25 0.62 5.73 0.3 2.3e-8 Skin colour saturation; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg08047338 chr2:75873982 MRPL19 0.48 6.72 0.35 8.06e-11 Response to antipsychotic treatment; CRC cis rs763121 0.853 rs5750668 chr22:39079964 T/C cg06022373 chr22:39101656 GTPBP1 0.79 12.37 0.56 4.15e-29 Menopause (age at onset); CRC cis rs7635838 0.892 rs9310381 chr3:11458466 A/G cg00170343 chr3:11313890 ATG7 0.41 6.26 0.33 1.22e-9 HDL cholesterol; CRC cis rs9783347 0.857 rs2124374 chr11:18313911 A/C cg15585147 chr11:18324498 HPS5 0.43 5.98 0.31 5.75e-9 Pancreatic cancer; CRC cis rs9409565 0.821 rs7858082 chr9:97063929 T/A cg04523069 chr9:97136363 HIATL1 -0.41 -6.22 -0.32 1.53e-9 Colorectal cancer (alcohol consumption interaction); CRC cis rs4363385 0.747 rs4845509 chr1:152981900 T/G cg25856811 chr1:152973957 SPRR3 -0.25 -6.85 -0.35 3.56e-11 Inflammatory skin disease; CRC cis rs763121 1.000 rs138457 chr22:38898051 T/C cg06022373 chr22:39101656 GTPBP1 -0.76 -12.53 -0.57 1.07e-29 Menopause (age at onset); CRC trans rs35110281 0.811 rs2838339 chr21:45075750 A/G cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO -0.52 -8.88 -0.44 4.34e-17 Mean corpuscular volume; CRC cis rs1218582 0.710 rs4845685 chr1:154878300 C/A cg16680214 chr1:154839983 KCNN3 -0.45 -8.95 -0.44 2.64e-17 Prostate cancer; CRC cis rs10504229 0.679 rs7813252 chr8:58136389 C/G cg05313129 chr8:58192883 C8orf71 -0.43 -6.15 -0.32 2.25e-9 Developmental language disorder (linguistic errors); CRC trans rs6066835 0.702 rs6066807 chr20:47267144 C/T cg21109867 chr19:55897418 RPL28 -0.74 -6.05 -0.32 3.88e-9 Multiple myeloma; CRC cis rs9911578 0.967 rs9907940 chr17:56663842 A/G cg12560992 chr17:57184187 TRIM37 0.92 17.06 0.69 3.31e-47 Intelligence (multi-trait analysis); CRC cis rs9916302 0.904 rs11078897 chr17:37415870 C/T cg15445000 chr17:37608096 MED1 0.41 9.08 0.45 1.06e-17 Glomerular filtration rate (creatinine); CRC cis rs2072499 0.750 rs2241109 chr1:156173082 C/T cg24450063 chr1:156163899 SLC25A44 1.07 17.09 0.69 2.6e-47 Testicular germ cell tumor; CRC cis rs4664293 0.647 rs4665082 chr2:160429966 T/G cg08347373 chr2:160653686 CD302 -0.38 -6.43 -0.33 4.52e-10 Monocyte percentage of white cells; CRC cis rs4253772 0.530 rs6008623 chr22:46710024 G/A cg24881330 chr22:46731750 TRMU 0.59 6.09 0.32 3.08e-9 LDL cholesterol;Cholesterol, total; CRC cis rs12545109 0.765 rs1960726 chr8:57411733 T/C cg09654669 chr8:57350985 NA -0.46 -7.45 -0.38 8.25e-13 Obesity-related traits; CRC cis rs7586879 0.638 rs13035244 chr2:25134009 T/C cg04586622 chr2:25135609 ADCY3 -0.55 -10.09 -0.49 4.8e-21 Body mass index; CRC cis rs12413816 0.818 rs35567671 chr10:13769722 C/A cg16485048 chr10:13749193 FRMD4A 0.51 7.77 0.39 1e-13 Red cell distribution width; CRC cis rs1559088 1.000 rs1974783 chr19:33551507 C/G cg27124370 chr19:33622961 WDR88 0.41 5.71 0.3 2.49e-8 Bone ultrasound measurement (broadband ultrasound attenuation); CRC cis rs9894429 0.646 rs12948797 chr17:79617384 G/A cg21984481 chr17:79567631 NPLOC4 -0.44 -7.35 -0.38 1.61e-12 Eye color traits; CRC cis rs2929278 0.589 rs11638972 chr15:44074691 C/G cg02155558 chr15:43621948 ADAL;LCMT2 -0.48 -6.84 -0.35 3.79e-11 Schizophrenia; CRC cis rs1059312 1.000 rs7135987 chr12:129280117 G/A cg21616243 chr12:129299702 MGC16384;SLC15A4 -0.64 -10.55 -0.5 1.3e-22 Systemic lupus erythematosus; CRC cis rs2721195 0.874 rs2721173 chr8:145744429 C/T cg15857475 chr8:145742913 RECQL4;LRRC14 0.76 13.64 0.6 7.09e-34 Age at first birth; CRC cis rs4727027 0.635 rs12111923 chr7:148885877 G/A cg12479418 chr7:148823350 ZNF425;ZNF398 0.51 6.76 0.35 6.45e-11 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC trans rs7613875 0.580 rs3774745 chr3:50204745 C/T cg21659725 chr3:3221576 CRBN -0.49 -7.69 -0.39 1.71e-13 Body mass index; CRC cis rs6540559 0.546 rs735693 chr1:210033988 A/C cg21951975 chr1:209979733 IRF6 0.46 5.87 0.31 1.08e-8 Cleft lip with or without cleft palate; CRC cis rs7666738 0.606 rs4577589 chr4:99087858 A/G cg05340658 chr4:99064831 C4orf37 0.49 7.21 0.37 3.95e-12 Colonoscopy-negative controls vs population controls; CRC cis rs738322 0.555 rs2284063 chr22:38544298 C/T cg25457927 chr22:38595422 NA 0.38 7.81 0.4 7.75e-14 Cutaneous nevi; CRC cis rs12048904 0.964 rs3188491 chr1:101338482 A/G cg16556008 chr1:101360663 SLC30A7;EXTL2 0.62 9.32 0.46 1.74e-18 Multiple sclerosis; CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg10757027 chr7:150783788 AGAP3 0.33 6.01 0.31 4.91e-9 Obesity-related traits; CRC cis rs60871478 0.730 rs62432226 chr7:792973 T/C cg13798912 chr7:905769 UNC84A 0.52 5.92 0.31 8.23e-9 Cerebrospinal P-tau181p levels; CRC trans rs1642645 0.831 rs6698877 chr1:42500436 T/C cg16926213 chr1:1841314 NA -0.44 -6.15 -0.32 2.22e-9 Left ventricular obstructive tract defect (maternal effect); CRC cis rs501120 0.657 rs649192 chr10:44741179 G/C cg09554077 chr10:44749378 NA 0.83 10.78 0.51 2.11e-23 Coronary artery disease;Coronary heart disease; CRC cis rs1448094 0.967 rs10863109 chr12:86328415 A/G cg02569458 chr12:86230093 RASSF9 0.37 6.47 0.34 3.47e-10 Major depressive disorder; CRC cis rs875971 0.638 rs7793569 chr7:66116633 T/G cg00343986 chr7:65444356 GUSB -0.49 -7.23 -0.37 3.38e-12 Aortic root size; CRC cis rs1152591 0.524 rs1255991 chr14:64661642 G/A cg21174375 chr14:64681225 SYNE2 0.39 6.41 0.33 5.04e-10 Atrial fibrillation; CRC cis rs2239547 0.657 rs4687554 chr3:52864135 T/C cg15147215 chr3:52552868 STAB1 -0.44 -6.15 -0.32 2.23e-9 Schizophrenia; CRC cis rs4443100 0.792 rs9612223 chr22:23389142 T/G cg14186256 chr22:23484241 RTDR1 0.47 5.76 0.3 1.97e-8 Serum parathyroid hormone levels; CRC trans rs79976124 0.879 rs17511467 chr6:66627293 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.76 9.54 0.47 3.31e-19 Type 2 diabetes; CRC trans rs7267979 0.932 rs433352 chr20:25467992 C/T cg17903999 chr18:56338584 MALT1 0.39 6.5 0.34 2.96e-10 Liver enzyme levels (alkaline phosphatase); CRC cis rs9393692 0.905 rs34916901 chr6:26286149 G/T cg00631329 chr6:26305371 NA -0.7 -13.84 -0.61 1.22e-34 Educational attainment; CRC cis rs1348850 0.632 rs1405718 chr2:178499809 C/T cg22681709 chr2:178499509 PDE11A -0.49 -9.23 -0.45 3.5e-18 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg23335946 chr1:185125966 C1orf25;C1orf26 0.47 6.11 0.32 2.85e-9 Thyroid stimulating hormone; CRC cis rs13191362 0.935 rs34009353 chr6:163007668 T/G cg21926612 chr6:163149169 PACRG;PARK2 0.74 10.83 0.51 1.37e-23 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC trans rs7976838 0.908 rs17122978 chr12:60167835 A/C cg16974014 chr22:22007515 MIR130B -0.48 -5.99 -0.31 5.38e-9 Response to zileuton treatment in asthma (FEV1 change interaction); CRC cis rs873946 0.586 rs61862838 chr10:134572282 C/T cg18305652 chr10:134549665 INPP5A 0.47 6.05 0.32 3.89e-9 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CRC cis rs6499255 0.904 rs2161631 chr16:69556948 C/A cg04110750 chr16:69646130 NFAT5 -0.49 -6.79 -0.35 5.34e-11 IgE levels; CRC cis rs875971 0.545 rs10950029 chr7:65634321 A/C cg02869306 chr7:64672164 INTS4L1 -0.41 -6.11 -0.32 2.78e-9 Aortic root size; CRC cis rs13108904 0.875 rs10024013 chr4:1280792 C/T cg21620606 chr4:1342894 KIAA1530 -0.41 -7.3 -0.37 2.25e-12 Obesity-related traits; CRC cis rs11190604 1.000 rs2495743 chr10:102329739 G/C cg16342193 chr10:102329863 NA -0.39 -6.3 -0.33 9.56e-10 Palmitoleic acid (16:1n-7) levels; CRC cis rs66887589 0.660 rs4833613 chr4:120150156 A/C cg09307838 chr4:120376055 NA -0.47 -7.35 -0.38 1.62e-12 Diastolic blood pressure; CRC cis rs1552244 1.000 rs6442147 chr3:10078247 A/G cg10729496 chr3:10149963 C3orf24 0.49 6.63 0.34 1.39e-10 Alzheimer's disease; CRC cis rs6582630 0.555 rs7969922 chr12:38529491 C/T cg13010199 chr12:38710504 ALG10B 0.49 6.57 0.34 1.95e-10 Drug-induced liver injury (flucloxacillin); CRC cis rs2404602 0.735 rs4886798 chr15:76673226 A/G cg03037974 chr15:76606532 NA 0.51 7.55 0.38 4.39e-13 Blood metabolite levels; CRC cis rs1552244 1.000 rs6442148 chr3:10078289 G/C cg16606324 chr3:10149918 C3orf24 0.7 9.79 0.48 4.82e-20 Alzheimer's disease; CRC cis rs2032447 0.802 rs198853 chr6:26104096 T/C cg03264133 chr6:25882463 NA 0.45 6.06 0.32 3.79e-9 Intelligence (multi-trait analysis); CRC cis rs7914558 0.966 rs7085598 chr10:104650128 T/C cg15744005 chr10:104629667 AS3MT -0.33 -7.19 -0.37 4.36e-12 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs4332037 0.539 rs56305291 chr7:2048706 A/G cg23422044 chr7:1970798 MAD1L1 -0.59 -7.1 -0.36 7.9e-12 Bipolar disorder; CRC cis rs13191362 1.000 rs13200329 chr6:163004418 G/A cg21926612 chr6:163149169 PACRG;PARK2 0.76 11.15 0.52 1.03e-24 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs1003719 0.788 rs2835595 chr21:38466203 G/T cg10648535 chr21:38446584 PIGP;TTC3 0.52 7.41 0.38 1.07e-12 Eye color traits; CRC cis rs6912958 0.516 rs242278 chr6:88047059 C/T cg08069147 chr6:88032118 GJB7;C6orf162 0.68 11.12 0.52 1.29e-24 Monocyte percentage of white cells; CRC cis rs172166 0.611 rs203883 chr6:28078356 A/G cg17949981 chr6:28129498 ZNF389 0.41 5.62 0.3 4.15e-8 Cardiac Troponin-T levels; CRC cis rs910316 0.737 rs175048 chr14:75479894 A/T cg03030879 chr14:75389066 RPS6KL1 0.44 6.75 0.35 6.78e-11 Height; CRC cis rs910316 1.000 rs12879542 chr14:75507525 C/T cg08847533 chr14:75593920 NEK9 0.95 18.15 0.71 1.66e-51 Height; CRC cis rs6951245 1.000 rs11768761 chr7:1069807 A/G cg22907277 chr7:1156413 C7orf50 0.71 7.39 0.38 1.26e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs524281 0.861 rs12226649 chr11:65842047 T/C cg16950941 chr11:66035639 RAB1B -0.58 -7.13 -0.37 6.39e-12 Electroencephalogram traits; CRC cis rs9311676 0.609 rs6770113 chr3:58379297 C/A cg06643156 chr3:58380774 PXK 0.41 6.33 0.33 7.82e-10 Systemic lupus erythematosus; CRC cis rs9420 0.961 rs1647405 chr11:57477889 C/T cg23127183 chr11:57508653 C11orf31 -0.53 -7.34 -0.38 1.67e-12 Schizophrenia; CRC trans rs1814175 0.692 rs1851873 chr11:49937767 A/G cg21153622 chr11:89784906 NA -0.43 -7.01 -0.36 1.39e-11 Height; CRC cis rs3996993 0.646 rs1051775 chr6:52658962 T/C cg20803780 chr6:52668592 GSTA1 0.36 6.48 0.34 3.43e-10 Hemoglobin concentration; CRC cis rs8180040 0.966 rs878659 chr3:47500662 G/A cg27129171 chr3:47204927 SETD2 0.52 8.15 0.41 7.64e-15 Colorectal cancer; CRC cis rs881375 0.967 rs7046108 chr9:123660339 A/G cg09586646 chr9:123605570 PSMD5;LOC253039 -0.51 -6.93 -0.36 2.2e-11 Rheumatoid arthritis; CRC cis rs769267 0.965 rs2965198 chr19:19473030 A/G cg01262667 chr19:19385393 TM6SF2 -0.37 -5.96 -0.31 6.34e-9 Tonsillectomy; CRC cis rs9303280 0.901 rs12950743 chr17:38049233 T/C cg00129232 chr17:37814104 STARD3 -0.46 -7.08 -0.36 8.59e-12 Self-reported allergy; CRC cis rs9611565 0.605 rs202638 chr22:41855458 A/G cg06634786 chr22:41940651 POLR3H 0.52 6.58 0.34 1.86e-10 Vitiligo; CRC cis rs898097 0.812 rs7406011 chr17:80829980 C/T cg03160526 chr17:80928410 B3GNTL1 -0.42 -6.09 -0.32 3.08e-9 Breast cancer; CRC cis rs1008375 1.000 rs10939747 chr4:17691166 C/A cg16339924 chr4:17578868 LAP3 0.46 6.11 0.32 2.88e-9 Parasitemia in Tripanosoma cruzi seropositivity; CRC trans rs1941687 0.505 rs9956918 chr18:31315878 C/G cg27147174 chr7:100797783 AP1S1 0.35 5.98 0.31 5.93e-9 Subjective well-being (multi-trait analysis);Subjective well-being; CRC cis rs28386778 0.897 rs2236736 chr17:61938248 G/T cg22520471 chr17:61851767 DDX42;CCDC47 0.73 11.49 0.54 6.58e-26 Prudent dietary pattern; CRC cis rs9911578 1.000 rs2567905 chr17:56782297 T/C cg12560992 chr17:57184187 TRIM37 0.9 16.39 0.67 1.5e-44 Intelligence (multi-trait analysis); CRC cis rs10504229 0.609 rs56289889 chr8:58116276 G/C cg02725872 chr8:58115012 NA -0.64 -11.55 -0.54 3.85e-26 Developmental language disorder (linguistic errors); CRC cis rs9611565 0.570 rs12159188 chr22:42121125 A/T cg03806693 chr22:41940476 POLR3H 0.77 10.47 0.5 2.56e-22 Vitiligo; CRC cis rs6545883 0.894 rs6709441 chr2:61436930 A/T cg15711740 chr2:61764176 XPO1 0.43 5.69 0.3 2.8e-8 Tuberculosis; CRC cis rs12545109 0.800 rs2670055 chr8:57421575 T/C cg09654669 chr8:57350985 NA -0.45 -7.22 -0.37 3.68e-12 Obesity-related traits; CRC cis rs9649465 0.935 rs3815458 chr7:123304323 A/T cg03229431 chr7:123269106 ASB15 -0.37 -5.71 -0.3 2.56e-8 Migraine; CRC cis rs17711722 0.585 rs6942660 chr7:65302406 C/T cg05627663 chr7:65219948 SNORA22;CCT6P1 0.49 7.37 0.38 1.41e-12 Calcium levels; CRC cis rs9640161 0.789 rs6964110 chr7:150041836 A/C cg13722127 chr7:150037890 RARRES2 0.37 5.96 0.31 6.41e-9 Blood protein levels;Circulating chemerin levels; CRC cis rs8031584 0.781 rs4779498 chr15:31177476 C/T cg14829155 chr15:31115871 NA -0.55 -8.56 -0.43 4.38e-16 Huntington's disease progression; CRC cis rs6545883 0.899 rs12473030 chr2:61720497 T/A cg15711740 chr2:61764176 XPO1 -0.5 -6.89 -0.36 2.85e-11 Tuberculosis; CRC cis rs2032447 0.670 rs71557318 chr6:26118570 T/C cg03264133 chr6:25882463 NA 0.42 5.69 0.3 2.83e-8 Intelligence (multi-trait analysis); CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg11078198 chr14:21572134 ZNF219 0.52 6.89 0.36 2.85e-11 Thyroid stimulating hormone; CRC cis rs1950626 0.750 rs72700530 chr14:101429459 G/C cg02351406 chr14:101447389 SNORD114-20;SNORD114-21 0.95 15.47 0.65 6.02e-41 Pelvic organ prolapse (moderate/severe); CRC cis rs7625357 0.964 rs10513679 chr3:169353184 C/T cg04414509 chr3:169351419 MECOM 0.61 8.27 0.41 3.29e-15 Childhood and early adolescence aggressive behavior; CRC cis rs10504229 0.635 rs72649130 chr8:58053810 G/T cg02290350 chr8:58132656 NA -0.61 -6.94 -0.36 2.1e-11 Developmental language disorder (linguistic errors); CRC cis rs9612 1.000 rs9612 chr19:44235517 A/G cg08581076 chr19:44259116 C19orf61 0.55 6.79 0.35 5.32e-11 Exhaled nitric oxide output; CRC cis rs2953174 0.529 rs3997219 chr2:241541619 T/C cg07929629 chr2:241523174 NA 0.64 8.52 0.43 5.72e-16 Bipolar disorder; CRC cis rs2645694 0.626 rs12502590 chr4:77823642 G/A cg18351406 chr4:77819688 ANKRD56 0.51 7.87 0.4 5.31e-14 Emphysema distribution in smoking; CRC cis rs2333194 0.869 rs177368 chr14:73761247 T/C cg19682024 chr14:74008259 HEATR4;ACOT1 -0.43 -6.46 -0.34 3.74e-10 Bipolar disorder with mood-incongruent psychosis; CRC trans rs1412337 1.000 rs1412337 chr1:168618641 C/T cg03540912 chr16:71792711 SNORD71;AP1G1 0.5 6.11 0.32 2.86e-9 Morbidity-free survival; CRC cis rs2075371 0.932 rs11766132 chr7:133993062 T/C cg02659138 chr7:134003124 SLC35B4 0.39 6.67 0.35 1.09e-10 Mean platelet volume; CRC cis rs7412746 0.658 rs6657388 chr1:150748786 A/G cg15448220 chr1:150897856 SETDB1 0.54 7.59 0.39 3.39e-13 Melanoma; CRC trans rs4332037 0.539 rs56180486 chr7:2050747 C/T cg11693508 chr17:37793320 STARD3 0.64 7.33 0.37 1.75e-12 Bipolar disorder; CRC cis rs3820068 0.532 rs78917815 chr1:15920821 A/G cg27534772 chr1:16042836 PLEKHM2 0.53 10.07 0.49 5.87e-21 Systolic blood pressure; CRC cis rs853679 0.517 rs7755442 chr6:28039015 T/C cg18032046 chr6:28092343 ZSCAN16 -0.49 -5.83 -0.31 1.31e-8 Depression; CRC cis rs367615 0.679 rs11241021 chr5:108812090 T/G cg17395555 chr5:108820864 NA 0.45 8.92 0.44 3.35e-17 Colorectal cancer (SNP x SNP interaction); CRC trans rs208515 0.525 rs10944868 chr6:66687508 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.9 11.4 0.53 1.3e-25 Exhaled nitric oxide levels; CRC cis rs2011503 1.000 rs75525243 chr19:19638218 G/A cg11584989 chr19:19387371 SF4 0.58 6.48 0.34 3.27e-10 Bipolar disorder; CRC cis rs7412746 0.658 rs4537557 chr1:150734436 A/G cg18016565 chr1:150552671 MCL1 0.44 6.06 0.32 3.76e-9 Melanoma; CRC trans rs2303319 0.504 rs1449641 chr2:162619567 T/C cg23919916 chr10:103825097 HPS6 -0.69 -5.99 -0.31 5.54e-9 Cognitive function; CRC cis rs12188164 0.543 rs2672722 chr5:453567 G/A cg26850624 chr5:429559 AHRR 0.52 8.8 0.44 7.95e-17 Cystic fibrosis severity; CRC cis rs6674176 0.628 rs2301993 chr1:44426025 G/A cg13606994 chr1:44402422 ARTN -0.33 -5.67 -0.3 3.07e-8 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Cognitive ability; CRC trans rs61931739 0.534 rs11053075 chr12:34207009 A/G cg26384229 chr12:38710491 ALG10B -0.54 -6.87 -0.35 3.29e-11 Morning vs. evening chronotype; CRC cis rs9488822 0.676 rs13210143 chr6:116389636 G/A cg05304507 chr6:116381966 FRK 0.29 7.97 0.4 2.57e-14 Cholesterol, total;LDL cholesterol; CRC cis rs6088580 0.634 rs3736762 chr20:33037336 C/T cg24642439 chr20:33292090 TP53INP2 0.36 6.17 0.32 2.06e-9 Glomerular filtration rate (creatinine); CRC cis rs738322 1.000 rs4381 chr22:38570791 T/C cg17652424 chr22:38574118 PLA2G6 -0.22 -6.73 -0.35 7.71e-11 Cutaneous nevi; CRC cis rs11039216 1 rs11039216 chr11:47406592 C/T cg20307385 chr11:47447363 PSMC3 0.75 12.39 0.56 3.37e-29 Neuroticism; CRC cis rs11212617 1.000 rs228590 chr11:108096141 A/G cg01991180 chr11:108092276 ATM;NPAT 0.43 6.26 0.33 1.19e-9 Response to metformin in type 2 diabetes (glycemic); CRC cis rs9399137 0.507 rs4895437 chr6:135317354 G/A cg22676075 chr6:135203613 NA 0.59 9.01 0.45 1.66e-17 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; CRC cis rs9291683 0.554 rs7668175 chr4:10125782 T/C cg11266682 chr4:10021025 SLC2A9 -0.44 -8.69 -0.43 1.73e-16 Bone mineral density; CRC cis rs4478858 0.611 rs7527645 chr1:31763787 T/C cg00250761 chr1:31883323 NA -0.43 -8.37 -0.42 1.68e-15 Alcohol dependence; CRC cis rs6570726 0.791 rs11155426 chr6:145817130 T/C cg05347473 chr6:146136440 FBXO30 0.4 6.12 0.32 2.64e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs847577 0.722 rs7790120 chr7:97712831 C/A cg24562669 chr7:97807699 LMTK2 0.76 16.79 0.68 4e-46 Breast cancer; CRC cis rs921968 0.541 rs4674314 chr2:219423520 A/G cg02176678 chr2:219576539 TTLL4 -0.55 -8.77 -0.44 9.84e-17 Mean corpuscular hemoglobin concentration; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg03217408 chr17:72919480 OTOP2;USH1G 0.5 7.01 0.36 1.38e-11 Response to antipsychotic treatment; CRC cis rs9296092 0.560 rs7765263 chr6:33525559 A/G cg13560919 chr6:33536144 NA -0.44 -6.28 -0.33 1.09e-9 Age at smoking initiation in chronic obstructive pulmonary disease; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg09022552 chr16:28962119 NFATC2IP 0.43 6.17 0.32 2.06e-9 Intelligence (multi-trait analysis); CRC cis rs6840360 0.571 rs875667 chr4:152525477 G/A cg09659197 chr4:152720779 NA 0.31 5.66 0.3 3.35e-8 Intelligence (multi-trait analysis); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg08855568 chr3:61547104 PTPRG 0.38 5.97 0.31 5.99e-9 Liver disease severity in Alagille syndrome; CRC cis rs6938 0.575 rs12909335 chr15:75214789 T/G cg18612461 chr15:75251733 NA 0.4 6.12 0.32 2.68e-9 Breast cancer; CRC trans rs61931739 0.500 rs11615231 chr12:34413330 T/C cg26384229 chr12:38710491 ALG10B 0.66 8.81 0.44 7.3e-17 Morning vs. evening chronotype; CRC cis rs3087591 0.960 rs2952991 chr17:29526742 T/C cg24425628 chr17:29625626 OMG;NF1 0.85 16.25 0.67 5.09e-44 Hip circumference; CRC cis rs7552404 0.690 rs11161620 chr1:76255228 A/G cg22875332 chr1:76189707 ACADM -0.56 -7.3 -0.37 2.14e-12 Blood metabolite levels;Acylcarnitine levels; CRC cis rs10504229 0.683 rs7459925 chr8:58111771 G/A cg02290350 chr8:58132656 NA -0.6 -8.3 -0.42 2.8e-15 Developmental language disorder (linguistic errors); CRC trans rs7829975 0.806 rs2428 chr8:8641145 C/T cg16141378 chr3:129829833 LOC729375 -0.41 -6.38 -0.33 6.14e-10 Mood instability; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg01737828 chr15:75230659 COX5A 0.46 6.37 0.33 6.45e-10 Response to antipsychotic treatment; CRC cis rs9457247 0.765 rs4710171 chr6:167430186 A/G cg07741184 chr6:167504864 NA 0.39 6.72 0.35 7.78e-11 Crohn's disease; CRC cis rs2070677 1.000 rs2515641 chr10:135351362 T/C cg20169779 chr10:135381914 SYCE1 0.79 11.39 0.53 1.42e-25 Gout; CRC cis rs1862618 0.525 rs2662016 chr5:56269047 A/G cg24531977 chr5:56204891 C5orf35 0.86 12.26 0.56 9.86e-29 Initial pursuit acceleration; CRC cis rs1008375 1.000 rs1006722 chr4:17618713 A/G cg04450456 chr4:17643702 FAM184B -0.36 -5.66 -0.3 3.24e-8 Parasitemia in Tripanosoma cruzi seropositivity; CRC trans rs7395662 0.548 rs4882000 chr11:48546496 A/G cg03929089 chr4:120376271 NA -0.46 -6.52 -0.34 2.57e-10 HDL cholesterol; CRC cis rs6933660 0.665 rs6921042 chr6:151732385 T/C cg14262678 chr6:151773367 RMND1;C6orf211 0.5 8.15 0.41 7.78e-15 Menarche (age at onset); CRC cis rs6502050 0.835 rs12600852 chr17:80104593 G/A cg09264619 chr17:80180166 NA -0.34 -5.81 -0.3 1.5e-8 Life satisfaction; CRC cis rs7493 0.901 rs17879517 chr7:95030646 T/C cg01874867 chr7:94954059 PON1 -0.48 -6.02 -0.32 4.57e-9 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs67478160 0.644 rs7159810 chr14:104294117 T/G cg01849466 chr14:104193079 ZFYVE21 -0.48 -8.29 -0.42 2.99e-15 Schizophrenia; CRC trans rs208520 0.955 rs12202599 chr6:67001573 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.8 9.78 0.47 5.36e-20 Exhaled nitric oxide output; CRC cis rs637571 0.510 rs10896052 chr11:65579600 C/A cg04055107 chr11:65626734 MUS81;CFL1 -0.42 -5.88 -0.31 1.02e-8 Eosinophil percentage of white cells; CRC cis rs936229 0.651 rs12908814 chr15:75132490 C/G cg14664628 chr15:75095509 CSK -0.7 -11.86 -0.55 3.01e-27 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); CRC cis rs9916302 0.851 rs2338795 chr17:37399364 T/G cg07936489 chr17:37558343 FBXL20 -0.83 -12.88 -0.58 4.96e-31 Glomerular filtration rate (creatinine); CRC cis rs7772486 0.846 rs866473 chr6:146353414 A/C cg05347473 chr6:146136440 FBXO30 0.36 5.74 0.3 2.1e-8 Lobe attachment (rater-scored or self-reported); CRC trans rs2303319 0.504 rs62189054 chr2:162624654 C/G cg25193742 chr10:104614220 C10orf32 -0.76 -6.46 -0.34 3.66e-10 Cognitive function; CRC cis rs317689 0.690 rs607797 chr12:69646010 T/C cg20891283 chr12:69753455 YEATS4 0.48 6.09 0.32 3.21e-9 Response to diuretic therapy; CRC cis rs6912958 0.754 rs1051131 chr6:88221546 A/G cg12350822 chr6:88032061 C6orf162;GJB7 -0.34 -6.41 -0.33 5.06e-10 Monocyte percentage of white cells; CRC trans rs1814175 0.817 rs11518158 chr11:49985633 G/T cg21153622 chr11:89784906 NA -0.37 -6.03 -0.32 4.33e-9 Height; CRC cis rs35306767 0.761 rs11253540 chr10:1011958 C/T cg20503657 chr10:835505 NA -0.88 -10.64 -0.51 6.45e-23 Eosinophil percentage of granulocytes; CRC cis rs3889199 0.924 rs7543389 chr1:59680536 A/G cg25881383 chr1:59680599 NA -0.38 -6.35 -0.33 7.07e-10 Pulse pressure; CRC cis rs394563 0.591 rs237026 chr6:149720681 G/A cg11245181 chr6:149772854 ZC3H12D -0.6 -10.66 -0.51 5.65e-23 Dupuytren's disease; CRC trans rs61931739 0.534 rs2667447 chr12:34133468 C/A cg26384229 chr12:38710491 ALG10B 0.5 7.02 0.36 1.3e-11 Morning vs. evening chronotype; CRC cis rs7666738 0.830 rs6846229 chr4:99016546 C/T cg17366294 chr4:99064904 C4orf37 0.43 7.28 0.37 2.52e-12 Colonoscopy-negative controls vs population controls; CRC cis rs977987 0.843 rs12928036 chr16:75483132 G/A cg03315344 chr16:75512273 CHST6 0.53 9.08 0.45 1e-17 Dupuytren's disease; CRC cis rs10751667 0.666 rs7123912 chr11:963936 T/C cg23136738 chr11:925521 AP2A2 -0.42 -7.09 -0.36 8.19e-12 Alzheimer's disease (late onset); CRC cis rs72615157 0.664 rs6953580 chr7:99825275 A/G cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.46 5.89 0.31 9.33e-9 Lung function (FEV1/FVC); CRC cis rs6700896 0.931 rs4655582 chr1:66153363 C/G cg04111102 chr1:66153794 NA 0.35 6.07 0.32 3.47e-9 C-reactive protein;Mean corpuscular volume;Mean corpuscular hemoglobin; CRC cis rs7666738 0.924 rs62318940 chr4:99064768 C/T cg05340658 chr4:99064831 C4orf37 0.5 6.99 0.36 1.53e-11 Colonoscopy-negative controls vs population controls; CRC cis rs1003719 0.788 rs3787782 chr21:38462909 T/C cg10648535 chr21:38446584 PIGP;TTC3 0.52 7.36 0.38 1.48e-12 Eye color traits; CRC cis rs12594515 0.506 rs74199860 chr15:45989190 C/T cg22117107 chr15:45993392 NA -0.45 -9.33 -0.46 1.67e-18 Waist circumference;Weight; CRC cis rs4820539 0.966 rs2283803 chr22:23454881 G/A cg14186256 chr22:23484241 RTDR1 0.87 16.79 0.68 3.95e-46 Bone mineral density; CRC cis rs6582630 0.621 rs10880656 chr12:38571220 A/C cg26384229 chr12:38710491 ALG10B -0.53 -7.62 -0.39 2.71e-13 Drug-induced liver injury (flucloxacillin); CRC cis rs972578 0.967 rs2038058 chr22:43334295 C/G cg01576275 chr22:43409880 NA -0.43 -6.78 -0.35 5.59e-11 Mean platelet volume; CRC cis rs7937682 0.575 rs10789851 chr11:111750955 G/C cg09085632 chr11:111637200 PPP2R1B 0.95 15.95 0.66 8.21e-43 Primary sclerosing cholangitis; CRC cis rs12024301 0.557 rs12036830 chr1:183601471 G/T cg11505048 chr1:183622726 RGL1;APOBEC4 0.75 6.81 0.35 4.6e-11 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs12477438 1.000 rs12053372 chr2:99810055 C/T cg14399236 chr2:99771627 LIPT1;TSGA10 -0.69 -8.21 -0.41 4.98e-15 Chronic sinus infection; CRC cis rs9322193 0.961 rs9027 chr6:149916057 T/A cg13206674 chr6:150067644 NUP43 0.56 8.05 0.41 1.51e-14 Lung cancer; CRC cis rs4728302 0.838 rs10264922 chr7:133598975 A/G cg10665199 chr7:133106180 EXOC4 0.38 5.77 0.3 1.8e-8 Intelligence;Intelligence (multi-trait analysis); CRC cis rs8114671 0.585 rs2236271 chr20:33523840 G/T cg07148914 chr20:33460835 GGT7 -0.42 -6.85 -0.35 3.6e-11 Height; CRC trans rs11039798 0.588 rs7483361 chr11:48593786 G/A cg03929089 chr4:120376271 NA 0.66 7.21 0.37 3.85e-12 Axial length; CRC cis rs294883 0.858 rs9355709 chr6:159700754 G/A cg14500486 chr6:159655392 FNDC1 -0.35 -5.75 -0.3 2.09e-8 Coronary artery disease; CRC cis rs3015497 0.646 rs871643 chr14:51107452 T/C cg26011998 chr14:51135199 SAV1 -0.44 -5.67 -0.3 3.08e-8 Mean platelet volume; CRC cis rs4862750 0.872 rs7671914 chr4:187878165 A/G cg03647317 chr4:187891568 NA -0.52 -9.56 -0.47 2.93e-19 Lobe attachment (rater-scored or self-reported); CRC cis rs4363385 0.818 rs3806222 chr1:153002606 C/T cg25856811 chr1:152973957 SPRR3 -0.26 -7.16 -0.37 5.44e-12 Inflammatory skin disease; CRC trans rs12478296 0.786 rs13409307 chr2:242995499 G/C cg18288967 chr1:45987694 PRDX1 0.68 7.73 0.39 1.3e-13 Obesity-related traits; CRC cis rs9916302 0.904 rs587343 chr17:37440603 C/T cg07936489 chr17:37558343 FBXL20 0.8 11.86 0.55 3.02e-27 Glomerular filtration rate (creatinine); CRC cis rs13064411 0.696 rs1386336 chr3:113144153 C/T cg10517650 chr3:113235015 CCDC52 -0.37 -5.89 -0.31 9.37e-9 Response to simvastatin treatment (PCSK9 protein level change); CRC cis rs9896933 0.775 rs615630 chr17:80730527 T/C cg15664640 chr17:80829946 TBCD 0.59 6.16 0.32 2.1e-9 Bone mineral accretion in asthma (oral corticosteroid dose interaction); CRC cis rs6681460 0.966 rs10749763 chr1:67062126 G/A cg02459107 chr1:67143332 SGIP1 0.47 7.87 0.4 5.24e-14 Presence of antiphospholipid antibodies; CRC cis rs7618915 0.501 rs9917834 chr3:52634619 A/C cg08222913 chr3:52553049 STAB1 -0.34 -6.35 -0.33 7.09e-10 Bipolar disorder; CRC cis rs10876993 0.928 rs10877008 chr12:58103592 A/G cg18357645 chr12:58087776 OS9 0.58 8.03 0.4 1.74e-14 Celiac disease or Rheumatoid arthritis; CRC cis rs853679 0.569 rs9348798 chr6:28143011 G/A cg15845792 chr6:28175446 NA 1.04 13.81 0.61 1.6e-34 Depression; CRC cis rs4481887 1.000 rs6671789 chr1:248482931 G/A cg00666640 chr1:248458726 OR2T12 0.55 9.62 0.47 1.79e-19 Common traits (Other); CRC cis rs858239 0.899 rs2268747 chr7:23313462 A/G cg00469287 chr7:23338798 C7orf30 0.48 6.1 0.32 2.97e-9 Cerebrospinal fluid biomarker levels; CRC trans rs2243480 1.000 rs35421653 chr7:65363429 C/A cg10756647 chr7:56101905 PSPH 0.69 7.25 0.37 3e-12 Diabetic kidney disease; CRC cis rs1003719 0.646 rs9985082 chr21:38501021 A/G cg10648535 chr21:38446584 PIGP;TTC3 -0.48 -6.7 -0.35 8.99e-11 Eye color traits; CRC cis rs7772486 0.790 rs4075694 chr6:146251108 G/C cg23711669 chr6:146136114 FBXO30 -0.72 -12.62 -0.57 4.76e-30 Lobe attachment (rater-scored or self-reported); CRC cis rs11098499 0.542 rs10440343 chr4:120309787 G/C cg09307838 chr4:120376055 NA 0.71 10.93 0.52 6.41e-24 Corneal astigmatism; CRC cis rs6933660 0.800 rs6930557 chr6:151755806 G/A cg14262678 chr6:151773367 RMND1;C6orf211 0.53 8.73 0.43 1.31e-16 Menarche (age at onset); CRC cis rs9658691 0.920 rs55803311 chr10:90753135 G/A cg03111039 chr10:90751583 FAS;ACTA2 -0.92 -6.67 -0.34 1.12e-10 Mosquito bite size; CRC cis rs1150668 0.796 rs213236 chr6:28324397 T/C cg15845792 chr6:28175446 NA 0.52 7.77 0.39 1.02e-13 Pubertal anthropometrics; CRC cis rs2658782 1.000 rs2608216 chr11:93149172 G/A cg21115391 chr11:93143810 CCDC67 -0.4 -5.91 -0.31 8.77e-9 Pulmonary function decline; CRC cis rs35110281 0.607 rs4819212 chr21:44977455 G/A cg04455712 chr21:45112962 RRP1B 0.39 7.27 0.37 2.62e-12 Mean corpuscular volume; CRC cis rs763121 0.853 rs5750649 chr22:39036769 T/C cg06022373 chr22:39101656 GTPBP1 0.81 13.71 0.6 3.61e-34 Menopause (age at onset); CRC trans rs72991 0.561 rs75755602 chr11:121231729 T/C cg27192990 chr6:129479024 LAMA2 -0.43 -6.14 -0.32 2.42e-9 Response to tocilizumab in rheumatoid arthritis; CRC cis rs1018836 0.770 rs12543806 chr8:91664011 C/T cg16814680 chr8:91681699 NA -0.91 -15.9 -0.66 1.19e-42 Ejection fraction in Tripanosoma cruzi seropositivity; CRC cis rs3809863 0.602 rs6504833 chr17:45396087 A/G cg08085267 chr17:45401833 C17orf57 -0.8 -13.42 -0.59 4.56e-33 Glaucoma (primary open-angle); CRC trans rs8073060 0.586 rs72829933 chr17:34056406 C/T cg19694781 chr19:47549865 TMEM160 1.08 13.25 0.59 2.06e-32 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; CRC cis rs4718428 0.705 rs12698547 chr7:66278258 T/C cg18252515 chr7:66147081 NA -0.55 -7.7 -0.39 1.58e-13 Corneal structure; CRC cis rs13256369 1.000 rs10095733 chr8:8574646 A/G cg17143192 chr8:8559678 CLDN23 0.47 6.29 0.33 9.96e-10 Obesity-related traits; CRC cis rs62064224 0.593 rs916663 chr17:30835833 A/C cg12855166 chr17:30846586 MYO1D 0.58 9.4 0.46 9.74e-19 Schizophrenia; CRC cis rs2860975 0.875 rs2211272 chr10:96765905 G/A cg09036531 chr10:96991505 NA -0.42 -5.79 -0.3 1.65e-8 Immune response to smallpox vaccine (IL-6); CRC cis rs2243480 1.000 rs7456042 chr7:65299778 T/C cg18252515 chr7:66147081 NA -1.17 -13.55 -0.6 1.59e-33 Diabetic kidney disease; CRC cis rs8103278 0.507 rs7260651 chr19:46260245 G/A cg14061069 chr19:46274453 DMPK 0.68 12.53 0.57 1.02e-29 Coronary artery disease; CRC cis rs3768617 0.811 rs10911233 chr1:183052585 G/A ch.1.3577855R chr1:183094577 LAMC1 0.64 9.45 0.46 6.58e-19 Fuchs's corneal dystrophy; CRC cis rs1862618 0.853 rs33325 chr5:56142547 G/C cg24531977 chr5:56204891 C5orf35 -0.8 -10.85 -0.51 1.17e-23 Initial pursuit acceleration; CRC cis rs909341 0.649 rs4809320 chr20:62282439 G/A cg16989086 chr20:62203971 PRIC285 -0.53 -6.7 -0.35 8.79e-11 Atopic dermatitis; CRC cis rs7762018 0.891 rs4716343 chr6:170143817 C/G cg24289452 chr6:170231220 NA -0.54 -6.01 -0.31 5.05e-9 Thiazide-induced adverse metabolic effects in hypertensive patients; CRC cis rs9826463 0.527 rs112722008 chr3:142053561 A/G cg20824294 chr3:142316082 PLS1 0.35 5.67 0.3 3.1e-8 QRS duration in Tripanosoma cruzi seropositivity; CRC cis rs7737355 0.947 rs31584 chr5:130993124 A/G cg06307176 chr5:131281290 NA 0.41 5.89 0.31 9.38e-9 Life satisfaction; CRC cis rs6952808 1.000 rs4721121 chr7:1892565 A/G cg02951883 chr7:2050386 MAD1L1 -0.68 -11.05 -0.52 2.44e-24 Bipolar disorder and schizophrenia; CRC cis rs1348850 0.608 rs2364845 chr2:178226240 T/C cg22681709 chr2:178499509 PDE11A -0.32 -5.97 -0.31 6.14e-9 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs1153858 1.000 rs7179743 chr15:45638331 G/C cg21132104 chr15:45694354 SPATA5L1 0.58 8.6 0.43 3.24e-16 Homoarginine levels; CRC cis rs738322 0.742 rs4821767 chr22:38614129 G/T cg25457927 chr22:38595422 NA 0.41 8.48 0.42 7.97e-16 Cutaneous nevi; CRC cis rs9403521 1.000 rs12528456 chr6:144003706 A/G cg18240653 chr6:144019428 PHACTR2 -0.55 -6.21 -0.32 1.62e-9 Obesity-related traits; CRC cis rs67311347 1.000 rs7648952 chr3:40457038 C/T cg24209194 chr3:40518798 ZNF619 -0.43 -6.57 -0.34 1.97e-10 Renal cell carcinoma; CRC cis rs11971779 0.638 rs77668044 chr7:139111085 T/A cg07862535 chr7:139043722 LUC7L2 0.86 9.52 0.46 3.92e-19 Diisocyanate-induced asthma; CRC cis rs8180040 0.726 rs7628747 chr3:47001990 A/T cg02527881 chr3:46936655 PTH1R -0.43 -7.91 -0.4 3.93e-14 Colorectal cancer; CRC cis rs7659604 0.537 rs6823818 chr4:122731699 G/C cg19748678 chr4:122722346 EXOSC9 0.65 10.16 0.49 2.75e-21 Type 2 diabetes; CRC cis rs7937682 0.562 rs527847 chr11:111369132 A/C cg09085632 chr11:111637200 PPP2R1B 0.64 9.47 0.46 5.67e-19 Primary sclerosing cholangitis; CRC cis rs6598955 0.724 rs884533 chr1:26585657 G/T cg00852783 chr1:26633632 UBXN11 0.43 7.07 0.36 9.24e-12 Obesity-related traits; CRC cis rs9733 0.566 rs112967224 chr1:150677263 G/A cg17724175 chr1:150552817 MCL1 0.6 9.66 0.47 1.39e-19 Tonsillectomy; CRC trans rs2243480 1.000 rs383402 chr7:65586653 A/C cg10756647 chr7:56101905 PSPH -0.65 -6.84 -0.35 3.76e-11 Diabetic kidney disease; CRC cis rs9914988 0.887 rs28873200 chr17:27149512 A/G cg07195577 chr17:27052828 TLCD1 0.41 5.92 0.31 7.89e-9 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs72627509 0.680 rs66790703 chr4:57773908 G/A cg26694713 chr4:57773883 REST 0.47 5.82 0.31 1.4e-8 Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); CRC cis rs4555082 0.915 rs2816632 chr14:105741355 C/T cg06808227 chr14:105710500 BRF1 0.58 9.13 0.45 6.85e-18 Mean platelet volume;Platelet distribution width; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg25026715 chr17:26989248 SUPT6H;SDF2 -0.4 -6.48 -0.34 3.29e-10 Myopia (pathological); CRC trans rs800082 0.516 rs2889043 chr3:144231238 C/T cg24215973 chr2:240111563 HDAC4 0.46 6.44 0.33 4.18e-10 Smoking behavior; CRC cis rs10504229 1.000 rs112272435 chr8:58170371 A/G cg02290350 chr8:58132656 NA -0.42 -5.96 -0.31 6.62e-9 Developmental language disorder (linguistic errors); CRC cis rs9457247 0.663 rs9459835 chr6:167417551 G/T cg07741184 chr6:167504864 NA 0.37 6.38 0.33 5.86e-10 Crohn's disease; CRC cis rs10924970 0.934 rs56681442 chr1:235466800 G/A cg26050004 chr1:235667680 B3GALNT2 0.4 6.0 0.31 5.32e-9 Asthma; CRC trans rs11847697 1.000 rs28591603 chr14:30477520 G/A cg01202639 chr12:100898608 NR1H4 0.51 6.64 0.34 1.29e-10 Body mass index; CRC cis rs1005277 0.579 rs2505194 chr10:38393881 C/T cg03665457 chr10:38645376 HSD17B7P2 -0.4 -5.61 -0.3 4.34e-8 Extrinsic epigenetic age acceleration; CRC cis rs898097 0.578 rs6502021 chr17:80907728 T/C cg03160526 chr17:80928410 B3GNTL1 0.5 8.17 0.41 6.73e-15 Breast cancer; CRC cis rs8060686 0.920 rs12448923 chr16:67839128 C/T cg04539111 chr16:67997858 SLC12A4 -0.48 -5.77 -0.3 1.78e-8 HDL cholesterol;Metabolic syndrome; CRC cis rs9322193 0.923 rs2342765 chr6:150180009 C/G cg05861140 chr6:150128134 PCMT1 -0.44 -7.4 -0.38 1.15e-12 Lung cancer; CRC cis rs9549328 0.643 rs4907567 chr13:113617533 C/T cg08614441 chr13:113633676 MCF2L 0.4 7.06 0.36 9.78e-12 Systolic blood pressure; CRC trans rs2727020 0.729 rs4980439 chr11:49342246 G/C cg21153622 chr11:89784906 NA -0.42 -7.1 -0.36 7.57e-12 Coronary artery disease; CRC cis rs6940638 0.688 rs6921388 chr6:27080205 A/G cg12292205 chr6:26970375 C6orf41 -0.47 -6.56 -0.34 2.13e-10 Intelligence (multi-trait analysis); CRC cis rs798554 0.704 rs798503 chr7:2789704 G/A cg19717773 chr7:2847554 GNA12 -0.39 -6.59 -0.34 1.75e-10 Height; CRC cis rs10751667 0.666 rs7394992 chr11:980690 G/C cg06064525 chr11:970664 AP2A2 -0.3 -6.01 -0.31 5.06e-9 Alzheimer's disease (late onset); CRC cis rs2243480 1.000 rs1723269 chr7:65472786 C/G cg18252515 chr7:66147081 NA -1.09 -12.55 -0.57 8.52e-30 Diabetic kidney disease; CRC cis rs7811142 1.000 rs11773661 chr7:100073069 G/C cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.62 7.8 0.4 8.12e-14 Platelet count; CRC cis rs6502050 0.835 rs8065037 chr17:80158966 T/G cg02741985 chr17:80059408 CCDC57 0.42 6.99 0.36 1.51e-11 Life satisfaction; CRC cis rs7493 0.755 rs17166861 chr7:95020602 G/C cg21856205 chr7:94953877 PON1 -0.47 -5.99 -0.31 5.45e-9 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs8072100 0.656 rs2610367 chr17:45569815 A/G cg08085267 chr17:45401833 C17orf57 -0.59 -9.21 -0.45 4.05e-18 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs7809950 1.000 rs2237677 chr7:107202502 A/C cg23024343 chr7:107201750 COG5 -0.61 -8.53 -0.43 5.4e-16 Coronary artery disease; CRC cis rs11971779 0.680 rs6960876 chr7:139112176 C/T cg23387468 chr7:139079360 LUC7L2 -0.4 -6.98 -0.36 1.63e-11 Diisocyanate-induced asthma; CRC cis rs1707322 0.752 rs61784798 chr1:46173481 C/T cg06784218 chr1:46089804 CCDC17 0.65 12.15 0.56 2.54e-28 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs9916302 0.706 rs9944459 chr17:37484185 T/C cg07936489 chr17:37558343 FBXL20 0.9 11.59 0.54 2.74e-26 Glomerular filtration rate (creatinine); CRC cis rs9906695 0.950 rs17652343 chr17:32572855 A/G cg12698626 chr17:32581466 CCL2 0.42 5.89 0.31 9.46e-9 Monocyte percentage of white cells; CRC cis rs9649213 0.574 rs7802560 chr7:97903806 A/G cg08684580 chr7:98029266 BAIAP2L1 0.3 5.6 0.3 4.51e-8 Prostate cancer (SNP x SNP interaction); CRC trans rs79976124 0.797 rs78317899 chr6:66652896 C/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.75 9.52 0.46 3.87e-19 Type 2 diabetes; CRC cis rs4730250 0.707 rs80095766 chr7:106901394 G/T cg02696742 chr7:106810147 HBP1 -0.53 -6.06 -0.32 3.83e-9 Osteoarthritis; CRC cis rs7617773 0.817 rs11720622 chr3:48246679 G/A cg11946769 chr3:48343235 NME6 0.55 7.88 0.4 4.9e-14 Coronary artery disease; CRC cis rs2692947 0.770 rs62153678 chr2:96558346 C/T cg23100626 chr2:96804247 ASTL 0.27 7.13 0.37 6.6e-12 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; CRC cis rs977987 0.836 rs7199062 chr16:75474827 G/A cg03315344 chr16:75512273 CHST6 0.53 9.1 0.45 9.1e-18 Dupuytren's disease; CRC cis rs7647973 0.769 rs7434187 chr3:49032967 C/T cg20833759 chr3:49053208 WDR6;DALRD3 0.75 11.45 0.53 9.19e-26 Menarche (age at onset); CRC trans rs7618501 1.000 rs4855862 chr3:49748833 C/T cg21659725 chr3:3221576 CRBN -0.91 -17.91 -0.7 1.52e-50 Intelligence (multi-trait analysis); CRC cis rs7113874 0.569 rs10160805 chr11:8600393 C/T cg02811074 chr11:8615871 STK33 0.35 6.06 0.32 3.76e-9 Body mass index in physically active individuals;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs17270561 0.943 rs4478398 chr6:25694684 T/C cg16482183 chr6:26056742 HIST1H1C 0.75 8.29 0.42 2.94e-15 Iron status biomarkers; CRC trans rs9858542 0.953 rs6779524 chr3:49450449 C/T cg21665057 chr3:196295764 WDR53;FBXO45 -0.64 -8.76 -0.43 1.06e-16 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs9311474 0.629 rs13081028 chr3:52555316 G/A cg11645453 chr3:52864694 ITIH4 0.35 6.52 0.34 2.63e-10 Electroencephalogram traits; CRC cis rs1707322 0.752 rs11211171 chr1:46168642 A/G cg06784218 chr1:46089804 CCDC17 0.65 12.15 0.56 2.54e-28 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs4400599 0.642 rs4364874 chr1:154167788 C/A cg26808167 chr1:154192205 UBAP2L;C1orf43 -0.38 -5.82 -0.31 1.37e-8 Platelet distribution width; CRC cis rs7618501 0.602 rs2624853 chr3:50128893 A/G cg24110177 chr3:50126178 RBM5 0.52 8.22 0.41 4.72e-15 Intelligence (multi-trait analysis); CRC cis rs7100689 0.542 rs7096715 chr10:82195949 T/C cg00277334 chr10:82204260 NA -0.65 -10.5 -0.5 1.91e-22 Post bronchodilator FEV1; CRC cis rs6570726 0.846 rs7773939 chr6:145927384 C/T cg23711669 chr6:146136114 FBXO30 -0.67 -11.14 -0.52 1.18e-24 Lobe attachment (rater-scored or self-reported); CRC cis rs806215 0.813 rs806175 chr7:127289435 A/G cg25922125 chr7:127225783 GCC1 0.53 6.26 0.33 1.17e-9 Type 2 diabetes; CRC cis rs13315871 1.000 rs11713214 chr3:58445991 C/T cg20936604 chr3:58311152 NA -0.73 -7.25 -0.37 3.06e-12 Cholesterol, total; CRC cis rs9868809 0.772 rs2286651 chr3:48694147 G/A cg07636037 chr3:49044803 WDR6 -0.64 -5.92 -0.31 8.27e-9 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; CRC cis rs4481887 0.893 rs10888355 chr1:248457180 G/A cg00666640 chr1:248458726 OR2T12 0.52 9.31 0.46 1.85e-18 Common traits (Other); CRC trans rs1728785 1.000 rs7196104 chr16:68579746 C/A cg04657470 chr2:198365150 HSPE1;HSPD1 0.58 7.07 0.36 9.08e-12 Ulcerative colitis; CRC cis rs832540 0.864 rs832576 chr5:56163255 C/A cg03609598 chr5:56110824 MAP3K1 -0.42 -5.83 -0.31 1.35e-8 Coronary artery disease; CRC cis rs561341 0.941 rs4525554 chr17:30312819 T/C cg19193384 chr17:30244184 NA -0.65 -7.49 -0.38 6.27e-13 Hip circumference adjusted for BMI; CRC trans rs637571 0.546 rs11227311 chr11:65585257 C/A cg17712092 chr4:129076599 LARP1B -0.61 -9.29 -0.46 2.25e-18 Eosinophil percentage of white cells; CRC trans rs79464052 0.571 rs76945386 chr5:140969091 T/C cg05255351 chr5:1503979 LPCAT1 -0.45 -6.07 -0.32 3.6e-9 Diffuse large B cell lymphoma; CRC cis rs12580194 0.957 rs73118932 chr12:55706631 C/T cg19537932 chr12:55886519 OR6C68 -0.52 -5.97 -0.31 5.99e-9 Cancer; CRC cis rs8078723 1.000 rs4795418 chr17:38164851 T/C cg17467752 chr17:38218738 THRA 0.73 12.0 0.55 9.38e-28 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); CRC trans rs6550704 0.687 rs9865314 chr3:22634337 A/G cg04500099 chr12:95610991 FGD6;VEZT -0.43 -6.2 -0.32 1.67e-9 Daytime sleep phenotypes; CRC cis rs936229 0.861 rs3935077 chr15:75120211 C/G cg14664628 chr15:75095509 CSK -1.01 -19.14 -0.73 2.1e-55 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); CRC trans rs8073060 0.533 rs178736 chr17:33928158 G/T cg19694781 chr19:47549865 TMEM160 -1.03 -14.37 -0.62 1.16e-36 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; CRC trans rs75828804 1.000 rs76558985 chr16:77577513 A/G cg19423196 chr10:82049429 MAT1A 0.54 6.26 0.33 1.17e-9 Intraocular pressure; CRC cis rs2361718 0.967 rs2361719 chr17:78103403 A/G cg27427491 chr17:78079615 GAA 0.4 6.56 0.34 2.11e-10 Yeast infection; CRC cis rs9467773 0.587 rs9467722 chr6:26352566 T/C cg09904177 chr6:26538194 HMGN4 -0.45 -6.35 -0.33 7.03e-10 Intelligence (multi-trait analysis); CRC cis rs6740322 0.895 rs10166994 chr2:43557977 G/C cg06169590 chr2:43455088 ZFP36L2;LOC100129726 -0.67 -8.19 -0.41 5.83e-15 Coronary artery disease; CRC cis rs9914988 0.943 rs9898892 chr17:27150750 T/C cg12682573 chr17:27188876 MIR451;MIR144 0.57 7.99 0.4 2.37e-14 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs832540 0.931 rs2591960 chr5:56238811 A/T cg18230493 chr5:56204884 C5orf35 0.47 6.91 0.36 2.53e-11 Coronary artery disease; CRC cis rs4713118 0.513 rs149950 chr6:28033039 T/G cg18032046 chr6:28092343 ZSCAN16 -0.42 -5.75 -0.3 2.06e-8 Parkinson's disease; CRC cis rs4700695 0.719 rs36922 chr5:65464856 C/T cg21114390 chr5:65439923 SFRS12 -0.65 -8.61 -0.43 3.14e-16 Facial morphology (factor 19); CRC cis rs3026101 0.671 rs3026136 chr17:5310308 G/C cg25236894 chr17:5323110 RPAIN;NUP88 0.42 6.9 0.36 2.74e-11 Body mass index; CRC cis rs9325144 0.555 rs1843867 chr12:38703855 A/G cg13010199 chr12:38710504 ALG10B -0.41 -6.0 -0.31 5.07e-9 Morning vs. evening chronotype; CRC cis rs6964587 1.000 rs2282970 chr7:91584281 A/G cg17063962 chr7:91808500 NA 0.82 14.51 0.62 3.19e-37 Breast cancer; CRC cis rs9527 0.590 rs7089680 chr10:104802071 C/T cg04362960 chr10:104952993 NT5C2 -0.59 -8.29 -0.42 2.94e-15 Arsenic metabolism; CRC cis rs2249694 0.803 rs3020501 chr10:135381592 C/G cg16964102 chr10:135390573 NA -0.42 -6.88 -0.35 3.08e-11 Obesity-related traits; CRC cis rs2230307 0.536 rs700533 chr1:100483822 A/G cg24955406 chr1:100503596 HIAT1 0.59 7.01 0.36 1.34e-11 Carotid intima media thickness; CRC cis rs826838 0.678 rs11182781 chr12:38610178 C/T cg13010199 chr12:38710504 ALG10B 0.45 5.7 0.3 2.72e-8 Heart rate; CRC cis rs17666538 0.792 rs7820788 chr8:601846 C/T cg07685180 chr8:600429 NA 0.87 8.68 0.43 1.92e-16 IgG glycosylation; CRC cis rs6952808 0.692 rs60755037 chr7:2030104 G/A cg21782813 chr7:2030301 MAD1L1 0.54 9.44 0.46 7.29e-19 Bipolar disorder and schizophrenia; CRC cis rs57221529 0.766 rs72706608 chr5:559203 C/T cg17948913 chr5:572064 NA 0.55 6.33 0.33 7.93e-10 Lung disease severity in cystic fibrosis; CRC cis rs61160187 0.556 rs62367862 chr5:60268961 C/A cg16298547 chr5:60138761 ELOVL7 -0.26 -5.61 -0.3 4.39e-8 Educational attainment (years of education);Educational attainment (college completion); CRC cis rs989128 0.600 rs739924 chr17:48631607 T/C cg24438145 chr17:48624694 SPATA20 0.44 6.26 0.33 1.2e-9 Type 2 diabetes; CRC cis rs600806 0.888 rs4603158 chr1:109879549 C/T cg23032129 chr1:109941072 SORT1 -0.28 -6.03 -0.32 4.28e-9 Intelligence (multi-trait analysis); CRC cis rs4689388 0.926 rs11725500 chr4:6293919 C/G cg25554036 chr4:6271136 WFS1 0.55 8.98 0.44 2.16e-17 Type 2 diabetes and other traits;Type 2 diabetes; CRC cis rs3785574 0.962 rs2727332 chr17:61878584 T/A cg11494091 chr17:61959527 GH2 0.38 5.94 0.31 7.44e-9 Height; CRC cis rs7666738 0.830 rs13137808 chr4:99047095 T/C cg05340658 chr4:99064831 C4orf37 0.6 9.35 0.46 1.4e-18 Colonoscopy-negative controls vs population controls; CRC cis rs9368481 0.761 rs9348746 chr6:26970357 C/G cg18278486 chr6:26987575 LOC100270746;C6orf41 -0.52 -8.32 -0.42 2.4e-15 Autism spectrum disorder or schizophrenia; CRC cis rs17666538 0.585 rs4735812 chr8:607766 C/G cg26554054 chr8:600488 NA 0.61 5.82 0.31 1.37e-8 IgG glycosylation; CRC cis rs3768716 0.500 rs777329 chr2:215742595 A/G cg04004882 chr2:215674386 BARD1 -0.61 -8.31 -0.42 2.62e-15 Neuroblastoma; CRC cis rs2836974 0.613 rs2245455 chr21:40548087 A/T cg17971929 chr21:40555470 PSMG1 -0.66 -9.97 -0.48 1.29e-20 Cognitive function; CRC cis rs758324 0.947 rs1875177 chr5:131202625 T/C cg06307176 chr5:131281290 NA 0.43 6.35 0.33 7.21e-10 Alzheimer's disease in APOE e4- carriers; CRC trans rs951252 0.504 rs11734405 chr4:146081096 C/T cg05989625 chr8:145661381 NFKBIL2 -0.45 -6.11 -0.32 2.81e-9 Hip circumference; CRC cis rs11212617 1.000 rs228594 chr11:108104525 A/G cg12106634 chr11:108092400 ATM;NPAT 0.4 5.82 0.31 1.43e-8 Response to metformin in type 2 diabetes (glycemic); CRC cis rs7647973 0.588 rs9883000 chr3:49667691 A/G cg03060546 chr3:49711283 APEH 0.7 8.41 0.42 1.22e-15 Menarche (age at onset); CRC cis rs938554 0.513 rs3775948 chr4:9995182 G/C cg00071950 chr4:10020882 SLC2A9 0.44 6.83 0.35 4.16e-11 Blood metabolite levels; CRC cis rs3785574 0.962 rs2584621 chr17:61912436 G/A cg23090583 chr17:61904693 PSMC5;FTSJ3 0.64 9.11 0.45 8.1e-18 Height; CRC cis rs56399783 0.901 rs6967664 chr7:2816384 A/G cg19731401 chr7:2775893 GNA12 0.68 7.37 0.38 1.36e-12 Childhood ear infection; CRC cis rs4625783 0.583 rs11077974 chr17:80095193 A/G cg22110888 chr17:80059540 CCDC57 0.4 6.44 0.33 4.17e-10 Blood metabolite levels; CRC cis rs9322193 0.884 rs9371201 chr6:150145001 C/T cg07701084 chr6:150067640 NUP43 0.57 7.74 0.39 1.2e-13 Lung cancer; CRC cis rs6582630 0.576 rs2387837 chr12:38403164 G/T cg26384229 chr12:38710491 ALG10B -0.52 -7.54 -0.38 4.69e-13 Drug-induced liver injury (flucloxacillin); CRC cis rs4713118 0.662 rs149947 chr6:27972433 A/T cg06470822 chr6:28175283 NA 0.9 13.45 0.6 3.52e-33 Parkinson's disease; CRC trans rs9825823 0.617 rs2083264 chr3:61074229 A/G cg00106211 chr6:36514552 STK38 0.43 6.11 0.32 2.78e-9 Depressive symptom measurement or major depressive disorder; CRC cis rs1320333 0.772 rs17786120 chr2:700580 A/T cg00500140 chr2:691012 NA 0.56 6.22 0.32 1.54e-9 Obesity-related traits; CRC cis rs6942756 1.000 rs66864889 chr7:128952560 G/A cg02491457 chr7:128862824 NA -0.75 -10.32 -0.49 8.04e-22 White matter hyperintensity burden; CRC cis rs698833 0.501 rs35347977 chr2:44506921 C/T cg04920474 chr2:44395004 PPM1B 0.4 6.1 0.32 3.02e-9 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; CRC cis rs8141529 0.702 rs132536 chr22:29302906 A/G cg15103426 chr22:29168792 CCDC117 -0.52 -7.37 -0.38 1.38e-12 Lymphocyte counts; CRC cis rs11628318 0.802 rs6575926 chr14:103050183 G/A cg23071808 chr14:103021642 NA -0.67 -8.63 -0.43 2.64e-16 Platelet count; CRC cis rs7635838 0.819 rs904474 chr3:11524648 C/G cg00170343 chr3:11313890 ATG7 0.43 6.49 0.34 3.24e-10 HDL cholesterol; CRC cis rs4665809 0.887 rs4665825 chr2:26333100 A/G cg25036284 chr2:26402008 FAM59B -0.46 -6.08 -0.32 3.26e-9 Gut microbiome composition (summer); CRC cis rs7666738 0.830 rs35685312 chr4:98858521 G/A cg05340658 chr4:99064831 C4orf37 0.56 8.33 0.42 2.21e-15 Colonoscopy-negative controls vs population controls; CRC cis rs6502050 0.805 rs6502061 chr17:80086158 C/T cg09264619 chr17:80180166 NA 0.38 6.44 0.33 4.28e-10 Life satisfaction; CRC cis rs12477438 0.798 rs7570657 chr2:99654281 G/C cg26064155 chr2:99771622 LIPT1;TSGA10 -0.63 -8.61 -0.43 3.15e-16 Chronic sinus infection; CRC cis rs875971 0.658 rs432667 chr7:65514633 A/G cg11764359 chr7:65958608 NA 0.57 9.01 0.44 1.75e-17 Aortic root size; CRC cis rs1656402 0.954 rs1190454 chr2:233435325 G/T cg03852847 chr2:233439513 NA -0.44 -7.5 -0.38 6.14e-13 Non-small cell lung cancer (survival); CRC cis rs4604732 0.527 rs77361748 chr1:247626475 C/T cg02104434 chr1:247694406 LOC148824;OR2C3 0.6 8.82 0.44 6.67e-17 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CRC cis rs10992471 0.603 rs10114912 chr9:95307863 C/A cg14631576 chr9:95140430 CENPP -0.38 -6.59 -0.34 1.75e-10 Visceral adipose tissue/subcutaneous adipose tissue ratio; CRC cis rs875971 0.545 rs2173571 chr7:65770379 G/A cg03233332 chr7:66118400 NA -0.42 -5.83 -0.31 1.3e-8 Aortic root size; CRC cis rs7213347 0.780 rs170041 chr17:2170216 C/T cg15816464 chr17:2026533 SMG6 -0.38 -6.31 -0.33 9.21e-10 Total body bone mineral density; CRC trans rs1973993 0.745 rs6593606 chr1:96968005 C/T cg10631902 chr5:14652156 NA -0.4 -6.76 -0.35 6.18e-11 Weight; CRC cis rs9814567 0.762 rs13093893 chr3:134292131 C/T cg06109529 chr3:134205091 CEP63;ANAPC13 0.7 8.78 0.44 9.1e-17 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs1552244 0.882 rs3732967 chr3:10015437 T/C cg00166722 chr3:10149974 C3orf24 0.61 7.92 0.4 3.81e-14 Alzheimer's disease; CRC cis rs4819052 0.851 rs7275468 chr21:46656499 C/A cg11663144 chr21:46675770 NA -0.7 -11.4 -0.53 1.31e-25 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs2243480 1.000 rs35058610 chr7:65390925 G/A cg12463550 chr7:65579703 CRCP 0.63 6.03 0.32 4.46e-9 Diabetic kidney disease; CRC cis rs6495122 0.644 rs62029217 chr15:75261899 C/T cg17294928 chr15:75287854 SCAMP5 0.49 7.1 0.36 7.66e-12 Caffeine consumption;Diastolic blood pressure;Coffee consumption; CRC cis rs780096 0.526 rs809058 chr2:27616790 T/C cg02592271 chr2:27665507 KRTCAP3 -0.26 -5.98 -0.31 5.86e-9 Total body bone mineral density; CRC cis rs7107174 0.901 rs4945275 chr11:78119822 G/A cg12700464 chr11:78128424 GAB2 -0.51 -6.39 -0.33 5.66e-10 Testicular germ cell tumor; CRC cis rs2019137 1.000 rs2019137 chr2:113973632 G/A cg21550016 chr2:113992930 PAX8;LOC440839;LOC654433 -0.52 -7.44 -0.38 9.02e-13 Lymphocyte counts; CRC cis rs4689388 0.890 rs6446481 chr4:6295583 C/A cg25554036 chr4:6271136 WFS1 0.53 8.43 0.42 1.13e-15 Type 2 diabetes and other traits;Type 2 diabetes; CRC cis rs2228479 0.850 rs11076619 chr16:89831243 C/A cg06558623 chr16:89946397 TCF25 1.12 10.45 0.5 2.84e-22 Skin colour saturation; CRC cis rs11711311 0.712 rs3773684 chr3:113334488 A/T cg06805542 chr3:113465803 ATP6V1A;NAA50 0.46 6.22 0.32 1.53e-9 IgG glycosylation; CRC cis rs5769765 0.908 rs9616370 chr22:50306316 A/G cg04121214 chr22:50244548 NA -0.39 -5.7 -0.3 2.74e-8 Schizophrenia; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg25971440 chr7:108166545 PNPLA8 0.49 6.89 0.36 2.92e-11 Response to antipsychotic treatment; CRC cis rs7618501 0.633 rs4688689 chr3:50035542 C/T cg24110177 chr3:50126178 RBM5 -0.48 -7.14 -0.37 5.92e-12 Intelligence (multi-trait analysis); CRC cis rs208515 0.525 rs10498841 chr6:66663706 C/T cg07460842 chr6:66804631 NA 0.9 11.42 0.53 1.18e-25 Exhaled nitric oxide levels; CRC cis rs801193 1.000 rs2707850 chr7:66203870 G/T cg05627663 chr7:65219948 SNORA22;CCT6P1 0.42 6.12 0.32 2.65e-9 Aortic root size; CRC cis rs9837602 1.000 rs9851645 chr3:99767409 G/C cg07805332 chr3:99536008 MIR548G;C3orf26 -0.48 -6.24 -0.33 1.37e-9 Breast cancer; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg05298461 chr20:33999889 UQCC 0.44 6.26 0.33 1.21e-9 Response to antipsychotic treatment; CRC cis rs6951245 1.000 rs74887741 chr7:1110658 G/T cg24642844 chr7:1081250 C7orf50 -0.79 -9.46 -0.46 5.91e-19 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs138857 0.515 rs9616375 chr22:50310600 G/A cg02269571 chr22:50332266 NA -0.87 -8.96 -0.44 2.39e-17 Mean platelet volume; CRC cis rs7511006 1.000 rs7364173 chr22:50681029 C/T cg16473166 chr22:50639996 SELO -0.52 -7.69 -0.39 1.74e-13 Obesity-related traits; CRC cis rs514406 0.929 rs485631 chr1:53330245 A/G cg08859206 chr1:53392774 SCP2 -0.46 -7.2 -0.37 4.07e-12 Monocyte count; CRC cis rs9926296 0.744 rs154656 chr16:89708003 T/A cg03605463 chr16:89740564 NA 0.6 9.25 0.45 2.85e-18 Vitiligo; CRC cis rs4713118 0.527 rs9461433 chr6:28095172 C/T cg12172441 chr6:28176163 NA 0.62 7.4 0.38 1.17e-12 Parkinson's disease; CRC cis rs9916302 0.861 rs9903363 chr17:37499604 C/G cg15445000 chr17:37608096 MED1 -0.45 -9.98 -0.48 1.15e-20 Glomerular filtration rate (creatinine); CRC cis rs1150668 0.796 rs1124132 chr6:28380321 T/G cg15845792 chr6:28175446 NA 0.58 8.62 0.43 2.79e-16 Pubertal anthropometrics; CRC trans rs7395662 0.571 rs10838947 chr11:48568693 G/T cg03929089 chr4:120376271 NA -0.46 -6.53 -0.34 2.51e-10 HDL cholesterol; CRC trans rs7395662 0.824 rs12787989 chr11:48970887 G/T cg21153622 chr11:89784906 NA -0.48 -7.62 -0.39 2.78e-13 HDL cholesterol; CRC cis rs6912958 0.781 rs1051148 chr6:88221892 T/G cg12350822 chr6:88032061 C6orf162;GJB7 -0.33 -6.35 -0.33 6.97e-10 Monocyte percentage of white cells; CRC cis rs9303280 0.901 rs7216558 chr17:38070071 C/T cg20243544 chr17:37824526 PNMT -0.43 -6.67 -0.34 1.12e-10 Self-reported allergy; CRC cis rs9488822 0.636 rs10872142 chr6:116369052 C/A cg26893134 chr6:116381904 FRK 0.26 7.6 0.39 3.03e-13 Cholesterol, total;LDL cholesterol; CRC cis rs478304 0.934 rs1193496 chr11:65537556 C/T cg08755490 chr11:65554678 OVOL1 -0.4 -5.98 -0.31 5.95e-9 Acne (severe); CRC cis rs155076 0.938 rs9509633 chr13:21844482 G/C cg25811766 chr13:21894605 NA -0.57 -6.0 -0.31 5.12e-9 White matter hyperintensity burden; CRC cis rs4604732 0.536 rs78019731 chr1:247626430 C/T cg12754571 chr1:247694271 LOC148824;OR2C3 0.41 5.78 0.3 1.74e-8 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CRC cis rs9325144 0.555 rs6582607 chr12:38717678 T/C cg13010199 chr12:38710504 ALG10B -0.43 -6.09 -0.32 3.2e-9 Morning vs. evening chronotype; CRC cis rs2882667 0.894 rs1433008 chr5:138333664 T/C cg09476006 chr5:138032270 NA 0.44 7.39 0.38 1.19e-12 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs7542091 0.637 rs9429826 chr1:210052146 G/A cg05527609 chr1:210001259 C1orf107 -0.44 -5.8 -0.3 1.57e-8 Monobrow; CRC cis rs449789 0.524 rs6912475 chr6:159747473 C/G cg14500486 chr6:159655392 FNDC1 0.48 7.19 0.37 4.4e-12 Pulse pressure; CRC cis rs7829975 0.535 rs17683510 chr8:8500724 A/G cg08975724 chr8:8085496 FLJ10661 0.38 5.93 0.31 7.87e-9 Mood instability; CRC cis rs172166 0.516 rs2622322 chr6:28117443 C/G cg06470822 chr6:28175283 NA 0.66 10.11 0.49 4.13e-21 Cardiac Troponin-T levels; CRC cis rs6951245 1.000 rs80212261 chr7:1114012 C/T cg04025307 chr7:1156635 C7orf50 0.68 7.22 0.37 3.65e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs2280018 0.526 rs2966129 chr16:15152927 A/C cg27102117 chr16:15229624 NA -0.46 -7.45 -0.38 8.42e-13 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid);Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CRC cis rs4713118 0.911 rs9295746 chr6:27730064 T/C cg06470822 chr6:28175283 NA 0.78 9.64 0.47 1.54e-19 Parkinson's disease; CRC cis rs875971 0.862 rs937494 chr7:65764678 T/A cg00343986 chr7:65444356 GUSB -0.4 -5.69 -0.3 2.77e-8 Aortic root size; CRC cis rs7552404 0.727 rs1159214 chr1:76317910 G/T cg03433033 chr1:76189801 ACADM -0.69 -9.31 -0.46 1.85e-18 Blood metabolite levels;Acylcarnitine levels; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg08858051 chr1:94313454 NA 0.46 6.4 0.33 5.38e-10 Response to antipsychotic treatment; CRC cis rs875971 0.862 rs6460279 chr7:65662761 T/C cg11764359 chr7:65958608 NA -0.58 -8.64 -0.43 2.54e-16 Aortic root size; CRC cis rs2153535 0.580 rs1832101 chr6:8460177 A/G cg07606381 chr6:8435919 SLC35B3 0.68 10.95 0.52 5.22e-24 Motion sickness; CRC cis rs789852 0.764 rs2794668 chr3:194316895 C/T cg21106136 chr3:194405973 FAM43A -0.74 -6.17 -0.32 2.06e-9 QT interval; CRC cis rs55823223 0.564 rs936391 chr17:73847799 A/G cg14829360 chr17:73884958 NA 0.43 6.87 0.35 3.15e-11 Psoriasis; CRC cis rs9948 0.655 rs76653480 chr2:97375549 C/T cg20312557 chr2:97357134 FER1L5 -0.61 -5.64 -0.3 3.57e-8 Erectile dysfunction and prostate cancer treatment; CRC trans rs1814175 0.817 rs80244685 chr11:49763292 C/A cg11707556 chr5:10655725 ANKRD33B -0.52 -9.67 -0.47 1.2e-19 Height; CRC cis rs2836974 0.897 rs34599551 chr21:40594898 C/A cg11890956 chr21:40555474 PSMG1 1.11 20.54 0.75 6.6e-61 Cognitive function; CRC cis rs7589728 1.000 rs2363731 chr2:88521793 C/T cg24977027 chr2:88469347 THNSL2 0.54 6.41 0.33 5e-10 Plasma clusterin levels; CRC cis rs10128264 0.902 rs1250583 chr10:80975004 A/G cg18737081 chr10:80999807 ZMIZ1 0.37 6.72 0.35 8.05e-11 Response to methotrexate in juvenile idiopathic arthritis; CRC cis rs4253772 0.591 rs6008595 chr22:46703860 A/T cg03482458 chr22:46692211 CN5H6.4;GTSE1 0.49 6.26 0.33 1.17e-9 LDL cholesterol;Cholesterol, total; CRC cis rs1865760 0.927 rs6915834 chr6:25935427 A/C cg17691542 chr6:26056736 HIST1H1C 0.54 7.69 0.39 1.74e-13 Height; CRC cis rs17376456 0.877 rs10060462 chr5:93455073 C/T cg09848695 chr5:92956644 FAM172A;MIR2277 0.65 6.03 0.32 4.38e-9 Diabetic retinopathy; CRC cis rs3736485 0.934 rs4775953 chr15:51873173 G/T cg08986416 chr15:51914746 DMXL2 -0.47 -6.74 -0.35 7.23e-11 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs2976388 0.647 rs2585138 chr8:143808951 C/T cg05569086 chr8:143859399 LYNX1 0.4 6.81 0.35 4.69e-11 Urinary tract infection frequency; CRC cis rs9788721 0.836 rs17405217 chr15:78731149 C/T cg18825076 chr15:78729989 IREB2 -0.5 -7.35 -0.38 1.62e-12 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio;Emphysema imaging phenotypes;Emphysema distribution in smoking;Local histogram emphysema pattern;Post bronchodilator FEV1/FVC ratio in COPD; CRC cis rs10986311 0.802 rs3780201 chr9:127104775 C/T cg14243010 chr9:127117328 LOC100129034;PSMB7 -0.4 -6.01 -0.31 5.03e-9 Vitiligo; CRC cis rs644799 1.000 rs611020 chr11:95567905 C/T cg25478527 chr11:95522999 CEP57;FAM76B 0.52 7.71 0.39 1.5e-13 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs34172651 0.583 rs4787649 chr16:24700215 C/T cg06028605 chr16:24865363 SLC5A11 -0.44 -7.04 -0.36 1.16e-11 Intelligence (multi-trait analysis); CRC cis rs4268898 0.931 rs60716082 chr2:24526265 T/A cg06627628 chr2:24431161 ITSN2 -0.56 -8.5 -0.42 6.87e-16 Asthma; CRC cis rs477895 0.568 rs34838337 chr11:63870892 T/C cg18225595 chr11:63971243 STIP1 0.43 5.61 0.3 4.31e-8 Mean platelet volume; CRC cis rs9487051 0.872 rs4601178 chr6:109611246 C/T cg01475377 chr6:109611718 NA -0.5 -9.48 -0.46 5.09e-19 Reticulocyte fraction of red cells; CRC cis rs13108904 0.967 rs13150571 chr4:1278636 C/G cg16405210 chr4:1374714 KIAA1530 -0.46 -6.34 -0.33 7.54e-10 Obesity-related traits; CRC cis rs2204008 0.777 rs6582664 chr12:37947022 A/G cg26384229 chr12:38710491 ALG10B -0.63 -9.56 -0.47 2.89e-19 Bladder cancer; CRC trans rs1455244 0.700 rs7229302 chr18:11508904 G/T cg10373780 chr19:8455179 RAB11B 0.4 6.04 0.32 4.12e-9 Schizophrenia; CRC cis rs7552404 0.731 rs931507 chr1:76401577 G/A cg03433033 chr1:76189801 ACADM -0.58 -7.43 -0.38 9.6e-13 Blood metabolite levels;Acylcarnitine levels; CRC cis rs11690935 1.000 rs35549875 chr2:172532392 A/G cg13550731 chr2:172543902 DYNC1I2 1.1 18.82 0.72 3.71e-54 Schizophrenia; CRC cis rs727563 0.565 rs132774 chr22:42031953 C/G cg03806693 chr22:41940476 POLR3H -0.7 -9.35 -0.46 1.39e-18 Crohn's disease;Inflammatory bowel disease; CRC cis rs2019137 0.560 rs11123172 chr2:113984303 C/T cg09704166 chr2:114031854 PAX8;LOC440839 0.35 6.68 0.35 1.04e-10 Lymphocyte counts; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg21866596 chr11:93474724 C11orf54;TAF1D 0.45 7.32 0.37 1.97e-12 Liver disease severity in Alagille syndrome; CRC cis rs2635047 0.811 rs9965170 chr18:44788274 C/T cg19077165 chr18:44547161 KATNAL2 -0.37 -5.78 -0.3 1.72e-8 Educational attainment; CRC cis rs6662572 0.723 rs72677543 chr1:46565329 A/T cg03123370 chr1:45965343 CCDC163P;MMACHC 0.48 6.24 0.33 1.33e-9 Blood protein levels; CRC cis rs1552244 1.000 rs2272123 chr3:10140115 G/A cg13047869 chr3:10149882 C3orf24 0.56 7.7 0.39 1.5700000000000001e-13 Alzheimer's disease; CRC cis rs11098499 0.909 rs28884220 chr4:120307211 A/G cg09307838 chr4:120376055 NA 0.71 10.95 0.52 5.47e-24 Corneal astigmatism; CRC trans rs1656966 1.000 rs1656966 chr3:186466252 C/T cg05913197 chr6:166796386 BRP44L 0.42 6.13 0.32 2.51e-9 Myopia (pathological); CRC cis rs939658 1.000 rs11072826 chr15:79461516 C/T cg17916960 chr15:79447300 NA 0.46 7.6 0.39 3.06e-13 Refractive error; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg23238458 chr12:89919833 GALNT4;WDR51B 0.45 6.3 0.33 9.6e-10 Response to antipsychotic treatment; CRC cis rs2549003 1.000 rs2070722 chr5:131824486 A/C cg21138405 chr5:131827807 IRF1 0.55 10.75 0.51 2.58e-23 Asthma (sex interaction); CRC cis rs910316 0.967 rs175505 chr14:75529619 C/T cg08847533 chr14:75593920 NEK9 -0.91 -16.52 -0.67 4.54e-45 Height; CRC cis rs10504229 1.000 rs67630725 chr8:58185580 G/A cg01721255 chr8:58191610 C8orf71 0.49 6.17 0.32 2e-9 Developmental language disorder (linguistic errors); CRC cis rs875971 0.723 rs28391294 chr7:65654315 T/C cg18876405 chr7:65276391 NA -0.52 -8.74 -0.43 1.22e-16 Aortic root size; CRC cis rs9649213 0.593 rs1076272 chr7:98031005 C/G cg21770322 chr7:97807741 LMTK2 0.51 8.23 0.41 4.31e-15 Prostate cancer (SNP x SNP interaction); CRC cis rs6951245 0.935 rs78573577 chr7:1089087 C/A cg20603222 chr7:1096387 C7orf50;GPR146 -0.73 -8.49 -0.42 7.07e-16 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs7811142 0.830 rs61735533 chr7:99955866 G/A cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.94 12.66 0.57 3.42e-30 Platelet count; CRC cis rs1799949 1.000 rs2271573 chr17:41327621 A/G cg25072359 chr17:41440525 NA 0.43 6.35 0.33 7.14e-10 Menopause (age at onset); CRC cis rs1018836 0.923 rs9643298 chr8:91552502 G/A cg16814680 chr8:91681699 NA -0.77 -13.11 -0.59 6.81e-32 Ejection fraction in Tripanosoma cruzi seropositivity; CRC cis rs9660180 0.967 rs2272908 chr1:1721479 A/G cg17747265 chr1:1875780 NA 0.72 12.53 0.57 1.05e-29 Body mass index; CRC cis rs629535 0.783 rs510632 chr8:70034570 A/G cg26132723 chr8:70041827 NA 0.35 5.72 0.3 2.41e-8 Dupuytren's disease; CRC cis rs7487075 0.820 rs12310125 chr12:46693154 A/G cg22049899 chr12:47219821 SLC38A4 0.31 6.01 0.31 4.98e-9 Itch intensity from mosquito bite; CRC cis rs7618915 0.570 rs11714088 chr3:52758942 A/C cg08222913 chr3:52553049 STAB1 -0.34 -6.15 -0.32 2.29e-9 Bipolar disorder; CRC cis rs6665290 0.901 rs61834004 chr1:227202782 G/A cg10327440 chr1:227177885 CDC42BPA -1.02 -21.82 -0.77 6.64e-66 Myeloid white cell count; CRC cis rs10992471 0.528 rs3739606 chr9:95237222 G/T cg14631576 chr9:95140430 CENPP -0.31 -5.64 -0.3 3.71e-8 Visceral adipose tissue/subcutaneous adipose tissue ratio; CRC cis rs7429990 0.965 rs1060407 chr3:47958037 G/T cg11946769 chr3:48343235 NME6 0.48 6.09 0.32 3.16e-9 Educational attainment (years of education); CRC cis rs2075371 0.764 rs1643034 chr7:134006176 A/G cg20476274 chr7:133979776 SLC35B4 0.74 13.03 0.58 1.44e-31 Mean platelet volume; CRC trans rs35094601 1.000 rs13031641 chr2:139228769 G/C cg25299176 chr17:1303341 YWHAE -0.46 -6.63 -0.34 1.42e-10 Schizophrenia; CRC cis rs9291683 0.552 rs11736410 chr4:10017241 G/A cg00071950 chr4:10020882 SLC2A9 0.68 13.18 0.59 3.97e-32 Bone mineral density; CRC cis rs6500602 0.647 rs1684600 chr16:4594671 C/T cg14951292 chr16:4525986 HMOX2;NMRAL1 -0.53 -8.13 -0.41 8.68e-15 Schizophrenia; CRC cis rs7927771 0.524 rs10838763 chr11:47794802 C/T cg20307385 chr11:47447363 PSMC3 0.45 6.57 0.34 1.92e-10 Subjective well-being; CRC cis rs71403859 0.614 rs12935422 chr16:71664225 T/A cg08717414 chr16:71523259 ZNF19 -0.99 -9.6 -0.47 2.08e-19 Post bronchodilator FEV1; CRC cis rs873946 0.648 rs12783354 chr10:134557235 T/A cg18305652 chr10:134549665 INPP5A 0.48 6.1 0.32 2.98e-9 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CRC cis rs2243480 1.000 rs316313 chr7:65593548 G/A cg25985355 chr7:65971099 NA -0.51 -5.87 -0.31 1.05e-8 Diabetic kidney disease; CRC cis rs1178968 1.000 rs4717756 chr7:72765458 C/G cg25889504 chr7:72793014 NA -0.55 -6.21 -0.32 1.62e-9 Triglyceride levels; CRC cis rs2415984 0.579 rs4485263 chr14:46967552 A/G cg14871534 chr14:47121158 RPL10L -0.4 -5.99 -0.31 5.53e-9 Number of children ever born; CRC cis rs4809627 1 rs4809627 chr20:45757655 C/T cg27589058 chr20:45804311 EYA2 -0.32 -5.66 -0.3 3.34e-8 Type 2 diabetes; CRC trans rs7615952 0.688 rs12638240 chr3:125541238 G/A cg07211511 chr3:129823064 LOC729375 -0.91 -13.23 -0.59 2.44e-32 Blood pressure (smoking interaction); CRC cis rs4819052 0.851 rs2838849 chr21:46671027 A/G cg02159808 chr21:46707872 POFUT2;LOC642852 0.49 6.54 0.34 2.4e-10 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs9303401 0.703 rs8072182 chr17:57211213 G/A cg10487724 chr17:56770010 TEX14;RAD51C 0.46 7.03 0.36 1.17e-11 Cognitive test performance; CRC cis rs2180341 0.595 rs7771391 chr6:127749656 C/G cg27446573 chr6:127587934 RNF146 0.58 7.83 0.4 6.94e-14 Breast cancer; CRC cis rs2549003 1.000 rs9282761 chr5:131822224 T/C cg02551604 chr5:131831745 NA -0.54 -8.34 -0.42 2e-15 Asthma (sex interaction); CRC cis rs595982 0.559 rs17206700 chr19:49361255 A/G cg15549821 chr19:49342101 PLEKHA4 -0.59 -6.95 -0.36 1.97e-11 Red cell distribution width; CRC cis rs7647973 0.710 rs6797299 chr3:49609794 G/T cg03060546 chr3:49711283 APEH 0.66 7.37 0.38 1.41e-12 Menarche (age at onset); CRC cis rs34779708 0.966 rs4934737 chr10:35512799 T/C cg03585969 chr10:35415529 CREM 0.56 7.49 0.38 6.44e-13 Inflammatory bowel disease;Crohn's disease; CRC cis rs67311347 1.000 rs12492035 chr3:40467110 G/A cg24209194 chr3:40518798 ZNF619 0.43 6.25 0.33 1.27e-9 Renal cell carcinoma; CRC cis rs1218582 0.772 rs10796935 chr1:154891363 G/T cg16680214 chr1:154839983 KCNN3 -0.46 -9.08 -0.45 1.01e-17 Prostate cancer; CRC cis rs6964587 0.967 rs34040612 chr7:91798916 G/T cg17063962 chr7:91808500 NA 0.8 13.01 0.58 1.7e-31 Breast cancer; CRC cis rs6952808 0.798 rs28970524 chr7:1927484 C/T cg20295408 chr7:1910781 MAD1L1 -0.43 -6.05 -0.32 3.99e-9 Bipolar disorder and schizophrenia; CRC cis rs2882667 0.964 rs12108892 chr5:138299630 G/A cg09476006 chr5:138032270 NA 0.53 9.11 0.45 8.19e-18 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs6460942 0.915 rs1595800 chr7:12439816 G/A cg06484146 chr7:12443880 VWDE -0.8 -8.55 -0.43 4.58e-16 Coronary artery disease; CRC trans rs11148252 0.634 rs1571189 chr13:52731004 A/T cg18335740 chr13:41363409 SLC25A15 0.48 7.08 0.36 8.93e-12 Lewy body disease; CRC cis rs12143943 0.934 rs17335392 chr1:204595899 C/T cg17419461 chr1:204415978 PIK3C2B 0.43 6.92 0.36 2.35e-11 Cognitive performance; CRC cis rs13064411 0.696 rs6768648 chr3:113234141 C/G cg10517650 chr3:113235015 CCDC52 -0.39 -6.92 -0.36 2.31e-11 Response to simvastatin treatment (PCSK9 protein level change); CRC cis rs116095464 0.867 rs10074958 chr5:230828 C/T cg22496380 chr5:211416 CCDC127 -0.86 -10.02 -0.48 8.73e-21 Breast cancer; CRC cis rs9322193 0.847 rs880246 chr6:150167108 G/A cg05861140 chr6:150128134 PCMT1 -0.4 -6.41 -0.33 5.19e-10 Lung cancer; CRC cis rs4665809 0.652 rs6727974 chr2:26524639 A/G cg08067268 chr2:26466485 HADHB;HADHA 0.49 6.69 0.35 9.48e-11 Gut microbiome composition (summer); CRC cis rs8044995 0.563 rs8059585 chr16:68376811 G/A cg05110241 chr16:68378359 PRMT7 -0.75 -7.86 -0.4 5.71e-14 Schizophrenia; CRC cis rs8018808 0.902 rs147316 chr14:77888664 C/T cg20045696 chr14:77926864 AHSA1 0.36 5.61 0.3 4.4e-8 Myeloid white cell count; CRC cis rs2735413 0.918 rs2344494 chr16:78078111 C/T cg04733911 chr16:78082701 NA -0.45 -7.5 -0.38 6.09e-13 Systolic blood pressure (alcohol consumption interaction); CRC cis rs4979906 1.000 rs11002247 chr10:79446901 T/C cg07817648 chr10:79422355 NA -0.43 -5.64 -0.3 3.57e-8 Mortality in heart failure; CRC cis rs4927850 1.000 rs7625570 chr3:195747398 A/G cg12923728 chr3:195709715 SDHAP1 -0.71 -10.99 -0.52 3.81e-24 Pancreatic cancer; CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg11135003 chr1:225998164 EPHX1 0.39 6.36 0.33 6.8e-10 Obesity-related traits; CRC cis rs672059 1.000 rs674343 chr1:183162052 G/A ch.1.3577855R chr1:183094577 LAMC1 0.5 7.16 0.37 5.23e-12 Hypertriglyceridemia; CRC cis rs4862750 1.000 rs4862750 chr4:187904043 C/T cg22105103 chr4:187893119 NA 0.64 11.17 0.52 8.66e-25 Lobe attachment (rater-scored or self-reported); CRC cis rs453301 0.653 rs7853 chr8:8890814 A/G cg06636001 chr8:8085503 FLJ10661 0.54 7.92 0.4 3.58e-14 Joint mobility (Beighton score); CRC cis rs501120 1.000 rs622956 chr10:44755183 A/G cg09554077 chr10:44749378 NA 0.89 13.32 0.59 1.14e-32 Coronary artery disease;Coronary heart disease; CRC cis rs736801 0.808 rs2706396 chr5:131796809 A/C cg00255919 chr5:131827918 IRF1 0.36 6.1 0.32 2.99e-9 Breast cancer;Mosquito bite size; CRC cis rs919433 0.679 rs10203581 chr2:198515900 G/A cg10820045 chr2:198174542 NA 0.33 5.67 0.3 3.06e-8 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC cis rs8058578 1.000 rs6565197 chr16:30706477 T/C cg02466173 chr16:30829666 NA -0.67 -9.87 -0.48 2.79e-20 Multiple myeloma; CRC cis rs7208859 0.573 rs73267873 chr17:29068457 C/T cg13385521 chr17:29058706 SUZ12P 0.6 7.41 0.38 1.1e-12 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs9329289 0.510 rs11251283 chr10:2555784 C/G cg15501526 chr10:2543763 NA 0.49 8.82 0.44 6.79e-17 Age-related hearing impairment; CRC cis rs9814567 0.964 rs12492930 chr3:134222722 A/G cg06109529 chr3:134205091 CEP63;ANAPC13 -0.81 -12.26 -0.56 1e-28 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs2839186 0.508 rs6518278 chr21:47640571 A/G cg26721908 chr21:47610096 LSS 0.47 6.81 0.35 4.55e-11 Testicular germ cell tumor; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg19531713 chr17:41277059 BRCA1;NBR2 0.47 6.84 0.35 3.88e-11 Response to antipsychotic treatment; CRC cis rs7618501 1.000 rs7634902 chr3:49762662 G/T cg24308560 chr3:49941425 MST1R 0.44 6.94 0.36 2.05e-11 Intelligence (multi-trait analysis); CRC cis rs6120849 0.754 rs6088686 chr20:33623437 C/T cg08999081 chr20:33150536 PIGU 0.44 5.73 0.3 2.25e-8 Protein C levels; CRC cis rs7615952 0.641 rs12488180 chr3:125782236 C/T cg04553112 chr3:125709451 NA -0.51 -5.89 -0.31 9.48e-9 Blood pressure (smoking interaction); CRC cis rs1577917 0.917 rs35038582 chr6:86721305 T/A cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.53 -6.9 -0.36 2.63e-11 Response to antipsychotic treatment; CRC cis rs910316 0.699 rs175039 chr14:75468950 G/C cg11812906 chr14:75593930 NEK9 -0.58 -8.87 -0.44 4.85e-17 Height; CRC cis rs3749237 0.964 rs1799845 chr3:49847623 A/G cg03060546 chr3:49711283 APEH 0.5 7.28 0.37 2.44e-12 Resting heart rate; CRC cis rs28655083 0.673 rs1872509 chr16:77058990 G/C cg01753188 chr16:77233325 SYCE1L;MON1B -0.63 -7.41 -0.38 1.09e-12 Lobe attachment (rater-scored or self-reported); CRC cis rs3772130 0.923 rs34865234 chr3:121560995 C/T cg20356878 chr3:121714668 ILDR1 0.53 8.22 0.41 4.69e-15 Cognitive performance; CRC cis rs78456975 1.000 rs13413096 chr2:1553588 G/A cg01028140 chr2:1542097 TPO -0.55 -5.74 -0.3 2.15e-8 Placebo response in major depressive disorder (% change in symptom score); CRC cis rs11690935 0.959 rs10184866 chr2:172608956 T/G cg13550731 chr2:172543902 DYNC1I2 -1.05 -18.1 -0.71 2.58e-51 Schizophrenia; CRC trans rs11098499 0.779 rs7356491 chr4:120381974 C/T cg25214090 chr10:38739885 LOC399744 0.66 10.56 0.5 1.18e-22 Corneal astigmatism; CRC cis rs10883723 0.773 rs11191313 chr10:104278618 C/T cg11453585 chr10:104263688 ACTR1A;SUFU 0.87 14.84 0.63 1.67e-38 Allergic disease (asthma, hay fever or eczema); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg24350360 chr1:225997662 EPHX1 0.37 6.13 0.32 2.51e-9 Response to antipsychotic treatment; CRC cis rs2795502 0.873 rs3121327 chr10:43388285 G/A cg20628663 chr10:43360327 NA 0.61 9.37 0.46 1.21e-18 Blood protein levels; CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg18986451 chr3:100428869 TFG -0.52 -6.26 -0.33 1.19e-9 Diisocyanate-induced asthma; CRC cis rs6840360 0.653 rs13136369 chr4:152731283 T/G cg09659197 chr4:152720779 NA -0.41 -8.6 -0.43 3.19e-16 Intelligence (multi-trait analysis); CRC cis rs2075371 0.611 rs1862045 chr7:134023412 A/G cg20476274 chr7:133979776 SLC35B4 0.54 7.86 0.4 5.55e-14 Mean platelet volume; CRC cis rs9322193 0.923 rs2880436 chr6:150180259 T/C cg00933542 chr6:150070202 PCMT1 0.32 6.22 0.32 1.47e-9 Lung cancer; CRC trans rs11098499 0.691 rs9996644 chr4:120238877 G/T cg25214090 chr10:38739885 LOC399744 0.53 8.46 0.42 8.78e-16 Corneal astigmatism; CRC cis rs7618915 0.547 rs2268026 chr3:52778347 T/C cg15147215 chr3:52552868 STAB1 -0.61 -10.07 -0.49 5.69e-21 Bipolar disorder; CRC trans rs11165623 0.564 rs7541109 chr1:96995960 C/A cg10631902 chr5:14652156 NA -0.4 -6.86 -0.35 3.48e-11 Hip circumference;Waist circumference; CRC cis rs2235642 0.685 rs2667681 chr16:1653206 C/T cg26528668 chr16:1614120 IFT140 0.38 5.9 0.31 9.26e-9 Coronary artery disease; CRC cis rs875971 1.000 rs3735148 chr7:65971009 T/G cg18912574 chr7:65842487 NCRNA00174 0.35 6.09 0.32 3.11e-9 Aortic root size; CRC cis rs1881797 1.000 rs12061460 chr1:247686787 G/A cg05639522 chr1:247681581 NA 0.46 6.98 0.36 1.68e-11 Acute lymphoblastic leukemia (childhood); CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg05628496 chr17:17991167 DRG2 0.49 6.35 0.33 7.29e-10 Thyroid stimulating hormone; CRC cis rs4689388 0.750 rs10001190 chr4:6284633 C/T cg25554036 chr4:6271136 WFS1 -0.44 -6.73 -0.35 7.56e-11 Type 2 diabetes and other traits;Type 2 diabetes; CRC cis rs13217239 0.646 rs10456352 chr6:26990358 A/T cg18867708 chr6:26865862 GUSBL1 0.38 5.82 0.31 1.39e-8 Schizophrenia; CRC cis rs7727544 1.000 rs7727038 chr5:131590257 C/T cg20512303 chr5:131592959 PDLIM4 0.3 5.79 0.3 1.68e-8 Blood metabolite levels; CRC cis rs2832191 0.791 rs2832178 chr21:30479858 T/G cg24692254 chr21:30365293 RNF160 -0.71 -12.7 -0.57 2.32e-30 Dental caries; CRC cis rs66887589 0.967 rs56173225 chr4:120509972 G/A cg09307838 chr4:120376055 NA -0.51 -7.77 -0.39 1.04e-13 Diastolic blood pressure; CRC cis rs11098499 0.691 rs9995716 chr4:120264996 T/C cg24375607 chr4:120327624 NA 0.48 7.66 0.39 2.1e-13 Corneal astigmatism; CRC cis rs2404602 0.735 rs1607015 chr15:76702429 C/T cg23625390 chr15:77176239 SCAPER -0.83 -12.36 -0.56 4.36e-29 Blood metabolite levels; CRC trans rs7395662 0.747 rs11040106 chr11:48889126 C/T cg21153622 chr11:89784906 NA 0.45 7.1 0.36 7.58e-12 HDL cholesterol; CRC cis rs7618915 0.501 rs2159644 chr3:52774530 C/T cg18404041 chr3:52824283 ITIH1 -0.41 -8.4 -0.42 1.36e-15 Bipolar disorder; CRC cis rs231513 0.911 rs231525 chr17:41951283 C/T cg26893861 chr17:41843967 DUSP3 -0.73 -7.36 -0.38 1.52e-12 Cognitive function; CRC cis rs9322193 0.923 rs9766886 chr6:149958184 T/C cg00933542 chr6:150070202 PCMT1 0.29 6.08 0.32 3.37e-9 Lung cancer; CRC trans rs2727020 0.636 rs10839275 chr11:49438962 T/A cg21153622 chr11:89784906 NA -0.37 -6.03 -0.32 4.36e-9 Coronary artery disease; CRC cis rs10504229 0.683 rs67077711 chr8:58139769 G/T cg21724239 chr8:58056113 NA 0.49 6.81 0.35 4.75e-11 Developmental language disorder (linguistic errors); CRC trans rs975369 1.000 rs1553399 chr7:25620866 A/C cg08255105 chr15:81489160 IL16 0.6 6.04 0.32 4.16e-9 Preeclampsia; CRC cis rs3785574 0.962 rs7215915 chr17:61828385 C/T cg22520471 chr17:61851767 DDX42;CCDC47 0.44 6.14 0.32 2.33e-9 Height; CRC cis rs6785206 0.892 rs2712429 chr3:128336221 A/C cg16766828 chr3:128327626 NA -0.51 -5.94 -0.31 7.4e-9 Lymphocyte percentage of white cells; CRC trans rs1346081 0.786 rs1425645 chr4:68028175 C/T cg27444651 chr4:13486108 RAB28 0.5 6.18 0.32 1.88e-9 Intelligence (multi-trait analysis); CRC cis rs9640161 0.789 rs4554381 chr7:150025567 G/A cg13722127 chr7:150037890 RARRES2 0.48 7.81 0.4 7.99e-14 Blood protein levels;Circulating chemerin levels; CRC cis rs1005277 0.565 rs2474565 chr10:38380828 A/G cg25517755 chr10:38738941 LOC399744 -0.44 -6.45 -0.33 4.07e-10 Extrinsic epigenetic age acceleration; CRC trans rs208520 0.526 rs7771233 chr6:66819784 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.14 -23.04 -0.79 1.32e-70 Exhaled nitric oxide output; CRC cis rs4332037 0.539 rs11764780 chr7:2020904 G/C cg23378565 chr7:2036160 MAD1L1 -0.48 -6.87 -0.35 3.13e-11 Bipolar disorder; CRC cis rs17270561 0.666 rs4712976 chr6:25842203 C/T cg16482183 chr6:26056742 HIST1H1C 0.73 9.52 0.46 3.77e-19 Iron status biomarkers; CRC trans rs3960554 0.932 rs76873475 chr7:75829199 C/A cg19862616 chr7:65841803 NCRNA00174 0.66 7.63 0.39 2.54e-13 Eotaxin levels; CRC cis rs7772486 0.846 rs2748496 chr6:146321829 T/A cg23711669 chr6:146136114 FBXO30 0.61 10.22 0.49 1.79e-21 Lobe attachment (rater-scored or self-reported); CRC cis rs59043219 1 rs59043219 chr1:209970610 G/A cg25204440 chr1:209979598 IRF6 0.59 9.43 0.46 7.65e-19 Crohn's disease;Inflammatory bowel disease;Alzheimer's disease (APOE e4 interaction); CRC trans rs12478296 1.000 rs6717667 chr2:242997530 C/T cg18288967 chr1:45987694 PRDX1 0.64 7.32 0.37 1.94e-12 Obesity-related traits; CRC cis rs6840360 0.615 rs4696266 chr4:152463421 A/G cg09659197 chr4:152720779 NA 0.31 5.64 0.3 3.6e-8 Intelligence (multi-trait analysis); CRC cis rs4862750 0.914 rs6553028 chr4:187876046 T/C cg03452623 chr4:187889614 NA -0.89 -19.5 -0.73 7.75e-57 Lobe attachment (rater-scored or self-reported); CRC cis rs2032447 0.670 rs198834 chr6:26114372 G/A cg26028573 chr6:26043587 HIST1H2BB -0.42 -6.08 -0.32 3.39e-9 Intelligence (multi-trait analysis); CRC cis rs1552244 0.882 rs68153882 chr3:10013110 T/C cg13047869 chr3:10149882 C3orf24 0.51 6.97 0.36 1.74e-11 Alzheimer's disease; CRC cis rs10504229 0.593 rs74760806 chr8:58024785 C/T cg22535103 chr8:58192502 C8orf71 -0.53 -6.32 -0.33 8.44e-10 Developmental language disorder (linguistic errors); CRC cis rs12497850 0.931 rs9835307 chr3:48857805 T/C cg20833759 chr3:49053208 WDR6;DALRD3 0.53 9.14 0.45 6.55e-18 Parkinson's disease; CRC cis rs1401999 1.000 rs6443926 chr3:183706630 A/C cg01324343 chr3:183735012 ABCC5 0.77 13.9 0.61 7e-35 Anterior chamber depth; CRC cis rs72615157 0.634 rs11762932 chr7:99792666 C/T cg19337854 chr7:99768885 GPC2 -0.49 -6.51 -0.34 2.84e-10 Lung function (FEV1/FVC); CRC cis rs9549260 0.755 rs9549252 chr13:41230141 A/G cg21288729 chr13:41239152 FOXO1 0.44 7.03 0.36 1.19e-11 Red blood cell count; CRC cis rs57590327 0.716 rs3772891 chr3:81776760 A/G cg07356753 chr3:81810745 GBE1 0.62 7.55 0.38 4.46e-13 Extraversion; CRC cis rs17253792 0.822 rs2147114 chr14:56077118 C/T cg24579896 chr14:56047964 C14orf33;KTN1 0.71 5.69 0.3 2.81e-8 Putamen volume; CRC cis rs1580019 0.563 rs896137 chr7:32579345 G/T cg14728415 chr7:32535168 LSM5;AVL9 0.45 6.38 0.33 5.97e-10 Cognitive ability; CRC cis rs12497850 0.931 rs11924597 chr3:48937790 T/C cg07636037 chr3:49044803 WDR6 1.03 18.47 0.71 9.49e-53 Parkinson's disease; CRC cis rs7772486 0.719 rs702317 chr6:146005010 C/T cg13319975 chr6:146136371 FBXO30 0.44 6.38 0.33 6.12e-10 Lobe attachment (rater-scored or self-reported); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg09283396 chr2:62423333 B3GNT2 0.45 6.45 0.34 4.1e-10 Intelligence (multi-trait analysis); CRC cis rs12586317 0.547 rs4982234 chr14:35460106 T/A cg05294307 chr14:35346193 BAZ1A -0.73 -8.21 -0.41 5.01e-15 Psoriasis; CRC trans rs6557786 0.636 rs17052934 chr8:24840319 A/C cg24139520 chr8:28573832 EXTL3 -0.49 -6.73 -0.35 7.47e-11 Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 2 peripheral neuropathy); CRC cis rs7072216 0.621 rs11189595 chr10:100167322 C/T cg26618903 chr10:100175079 PYROXD2 -0.49 -7.34 -0.38 1.68e-12 Metabolite levels; CRC trans rs6500957 0.920 rs17648524 chr16:7459683 C/G cg20488697 chr17:79885644 LOC92659;MAFG 0.42 6.04 0.32 4.23e-9 Spherical equivalent (joint analysis main effects and education interaction); CRC trans rs1814175 0.645 rs11040671 chr11:49958776 G/A cg03929089 chr4:120376271 NA -0.91 -16.17 -0.67 1.06e-43 Height; CRC cis rs912057 0.833 rs1294424 chr6:6744135 G/A cg06612196 chr6:6737390 NA 0.51 8.17 0.41 6.92e-15 Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction); CRC cis rs4930103 0.935 rs4930110 chr11:2026701 G/C cg06197492 chr11:2016605 H19 0.39 5.87 0.31 1.04e-8 DNA methylation (parent-of-origin);DNA methylation (variation); CRC cis rs4780401 0.728 rs7198518 chr16:11771094 C/G cg01061890 chr16:11836724 TXNDC11 -0.42 -5.8 -0.3 1.53e-8 Rheumatoid arthritis; CRC cis rs10540 1.000 rs61877775 chr11:521462 C/T cg03934478 chr11:495069 RNH1 0.7 7.36 0.38 1.45e-12 Body mass index; CRC cis rs6543140 0.964 rs1523206 chr2:103070175 A/T cg03938978 chr2:103052716 IL18RAP 0.41 6.55 0.34 2.21e-10 Blood protein levels; CRC cis rs9916302 0.851 rs12936996 chr17:37665554 A/G cg00129232 chr17:37814104 STARD3 0.53 7.81 0.4 7.74e-14 Glomerular filtration rate (creatinine); CRC trans rs11039798 0.920 rs11040013 chr11:48782862 G/A cg15704280 chr7:45808275 SEPT13 0.63 6.04 0.32 4.07e-9 Axial length; CRC cis rs853679 0.517 rs9348794 chr6:28117757 T/A cg23161317 chr6:28129485 ZNF389 0.53 6.43 0.33 4.52e-10 Depression; CRC cis rs9787249 0.915 rs6664570 chr1:40206298 G/A cg02773041 chr1:40204384 PPIE 0.64 9.5 0.46 4.58e-19 Blood protein levels; CRC cis rs4727027 0.716 rs4727020 chr7:148837317 C/T cg23583168 chr7:148888333 NA -0.79 -11.72 -0.54 9.42e-27 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC cis rs117623576 0.941 rs16932939 chr10:32407862 T/C cg03047570 chr10:32398778 NA -0.83 -9.19 -0.45 4.47e-18 Anti-saccade response; CRC cis rs13108904 0.935 rs2293633 chr4:1291640 T/C cg23123621 chr4:1343375 KIAA1530 0.36 6.68 0.35 1.03e-10 Obesity-related traits; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg08330919 chr4:40058921 LOC344967;N4BP2 0.44 6.96 0.36 1.85e-11 Liver disease severity in Alagille syndrome; CRC cis rs1223397 0.651 rs2458312 chr6:13309989 G/A cg20827128 chr6:13274284 PHACTR1 0.39 5.95 0.31 6.85e-9 Blood pressure; CRC cis rs72781680 0.898 rs72782138 chr2:24048162 T/C cg08917208 chr2:24149416 ATAD2B 0.9 8.87 0.44 4.67e-17 Lymphocyte counts; CRC cis rs4970988 0.527 rs12067556 chr1:150614535 G/A cg18016565 chr1:150552671 MCL1 0.51 7.23 0.37 3.46e-12 Urate levels; CRC cis rs262150 1.000 rs262149 chr7:158778256 A/G cg19418458 chr7:158789849 NA 0.45 7.44 0.38 8.91e-13 Facial morphology (factor 20); CRC trans rs10504229 0.953 rs67886764 chr8:58187117 T/C cg04077850 chr5:125800366 GRAMD3 0.37 6.27 0.33 1.15e-9 Developmental language disorder (linguistic errors); CRC trans rs1005277 0.579 rs176838 chr10:38371899 A/T cg17830980 chr10:43048298 ZNF37B 0.6 10.08 0.49 5.29e-21 Extrinsic epigenetic age acceleration; CRC cis rs7044106 0.762 rs3904197 chr9:123480378 C/T cg09419670 chr9:123605666 PSMD5;LOC253039 0.71 11.76 0.54 6.69e-27 Hip circumference adjusted for BMI; CRC cis rs185694 1.000 rs202098 chr13:30896774 G/T cg04551440 chr13:30881194 KATNAL1 -0.61 -6.33 -0.33 7.8e-10 Antineutrophil cytoplasmic antibody-associated vasculitis; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg11751927 chr11:117857137 IL10RA 0.44 6.11 0.32 2.87e-9 Anxiety disorder; CRC cis rs11764590 0.724 rs1533829 chr7:2082841 A/G cg14004847 chr7:1930337 MAD1L1 -0.42 -5.77 -0.3 1.86e-8 Neuroticism; CRC cis rs6543140 0.964 rs7561351 chr2:103077780 A/G cg09003973 chr2:102972529 NA 0.41 5.83 0.31 1.33e-8 Blood protein levels; CRC cis rs2836974 0.931 rs7283569 chr21:40644062 T/G cg17971929 chr21:40555470 PSMG1 0.83 11.88 0.55 2.57e-27 Cognitive function; CRC cis rs1348850 0.598 rs1405717 chr2:178500101 G/T cg02961200 chr2:178257176 LOC100130691;AGPS 0.61 8.7 0.43 1.58e-16 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs9549367 0.789 rs3764124 chr13:113897320 C/T cg00898013 chr13:113819073 PROZ -0.47 -6.74 -0.35 7.23e-11 Platelet distribution width; CRC cis rs7113874 0.569 rs10769915 chr11:8597449 C/G cg17679104 chr11:8615758 STK33 -0.36 -6.05 -0.32 4.05e-9 Body mass index in physically active individuals;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs9292777 0.720 rs1025969 chr5:40402913 C/T cg09067459 chr5:40385259 NA -0.55 -8.97 -0.44 2.31e-17 Crohn's disease;Multiple sclerosis; CRC cis rs6951245 0.872 rs77569514 chr7:1085508 G/A cg03188948 chr7:1209495 NA 0.64 6.59 0.34 1.72e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs6500602 0.767 rs8060219 chr16:4480158 T/A cg14951292 chr16:4525986 HMOX2;NMRAL1 0.58 8.46 0.42 9.08e-16 Schizophrenia; CRC cis rs7258465 1.000 rs7251653 chr19:18608283 C/T cg01065977 chr19:18549689 ISYNA1 -0.41 -6.38 -0.33 6.05e-10 Breast cancer; CRC trans rs9395066 0.545 rs4711805 chr6:44870102 T/C cg04786201 chr1:17185605 NA 0.29 6.09 0.32 3.17e-9 Height; CRC cis rs4665809 0.838 rs7565843 chr2:26292912 G/C cg25036284 chr2:26402008 FAM59B -0.46 -5.99 -0.31 5.4e-9 Gut microbiome composition (summer); CRC cis rs12760731 0.565 rs12036491 chr1:178163651 C/A cg00404053 chr1:178313656 RASAL2 1.05 10.93 0.52 6.36e-24 Obesity-related traits; CRC cis rs1552172 0.881 rs1471634 chr1:145702115 A/G cg25221984 chr1:145714143 CD160 0.38 5.75 0.3 2.05e-8 Breast cancer; CRC cis rs644799 0.601 rs7902 chr11:95565288 A/G cg03916912 chr11:95522834 CEP57;FAM76B 0.77 13.4 0.59 5.63e-33 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs8177179 0.967 rs9820225 chr3:133449189 A/G cg16262614 chr3:133464971 TF 0.5 9.58 0.47 2.47e-19 Iron status biomarkers (transferrin levels); CRC trans rs1814175 0.817 rs4084376 chr11:49831160 T/C cg15704280 chr7:45808275 SEPT13 -1.0 -19.82 -0.74 4.3e-58 Height; CRC trans rs9467711 0.606 rs34273322 chr6:26415409 T/A cg06606381 chr12:133084897 FBRSL1 -0.83 -6.42 -0.33 4.83e-10 Autism spectrum disorder or schizophrenia; CRC cis rs2882667 0.652 rs6596463 chr5:138444926 A/G cg04439458 chr5:138467593 SIL1 -0.32 -5.76 -0.3 1.89e-8 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs728616 0.867 rs1054054 chr10:81682728 C/T cg11900509 chr10:81946545 ANXA11 -0.66 -6.66 -0.34 1.14e-10 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs4073582 0.595 rs708472 chr11:65930990 A/G cg14036092 chr11:66035641 RAB1B 0.55 9.01 0.44 1.68e-17 Gout; CRC cis rs460214 0.564 rs458465 chr21:40024644 A/T cg05519781 chr21:40033154 ERG -0.38 -5.88 -0.31 1e-8 Response to cognitive-behavioural therapy in anxiety disorder; CRC trans rs2055729 0.813 rs55999429 chr8:9741185 G/C cg06636001 chr8:8085503 FLJ10661 -0.46 -6.21 -0.32 1.64e-9 Multiple myeloma (hyperdiploidy); CRC cis rs798554 0.759 rs1636255 chr7:2892804 A/C cg13628971 chr7:2884303 GNA12 -0.59 -7.96 -0.4 2.86e-14 Height; CRC cis rs1448094 0.654 rs7133797 chr12:86294184 G/C cg19622623 chr12:86230825 RASSF9 -0.42 -6.75 -0.35 6.68e-11 Major depressive disorder; CRC cis rs7567389 0.600 rs7590030 chr2:128055967 G/A cg09760422 chr2:128146352 NA -0.34 -5.68 -0.3 2.99e-8 Self-rated health; CRC cis rs28386778 0.863 rs2251164 chr17:61884120 G/A cg23090583 chr17:61904693 PSMC5;FTSJ3 1.05 20.56 0.75 5.27e-61 Prudent dietary pattern; CRC trans rs9693857 0.520 rs6601320 chr8:9355888 G/C cg08975724 chr8:8085496 FLJ10661 0.43 6.02 0.31 4.61e-9 Systolic blood pressure; CRC cis rs3857536 0.842 rs2188590 chr6:66939534 A/G cg07460842 chr6:66804631 NA -0.43 -5.81 -0.3 1.48e-8 Blood trace element (Cu levels); CRC cis rs6951245 1.000 rs11770909 chr7:1086716 G/A cg24642844 chr7:1081250 C7orf50 -0.8 -9.39 -0.46 9.99e-19 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs2675662 0.525 rs12264025 chr10:75494450 A/G cg23231163 chr10:75533350 FUT11 -0.37 -5.89 -0.31 9.32e-9 Psoriasis vulgaris;Psoriasis; CRC cis rs10751667 0.643 rs10902237 chr11:944801 C/A ch.11.42038R chr11:967971 AP2A2 0.61 10.34 0.5 6.76e-22 Alzheimer's disease (late onset); CRC cis rs10193935 1.000 rs13386385 chr2:42436928 G/T cg27598129 chr2:42591480 NA -0.72 -8.11 -0.41 9.89e-15 Colonoscopy-negative controls vs population controls; CRC cis rs7692995 1.000 rs16896210 chr4:17992332 A/G cg08925142 chr4:18023851 LCORL -0.53 -5.84 -0.31 1.22e-8 Height; CRC trans rs264943 0.600 rs11677232 chr2:104096271 G/A cg24033067 chr14:24674799 TSSK4 -0.41 -6.01 -0.31 4.8e-9 HIV-1 viral setpoint; CRC cis rs9549260 0.664 rs1360719 chr13:41225874 G/C cg21288729 chr13:41239152 FOXO1 0.49 7.62 0.39 2.75e-13 Red blood cell count; CRC cis rs1150688 1 rs1150688 chr6:28162780 T/C cg15845792 chr6:28175446 NA 0.65 9.78 0.47 5.56e-20 Autism spectrum disorder or schizophrenia; CRC cis rs8060686 0.920 rs112894876 chr16:67812039 G/C cg08314208 chr16:67682810 RLTPR -0.65 -7.04 -0.36 1.12e-11 HDL cholesterol;Metabolic syndrome; CRC cis rs4731207 0.671 rs12706626 chr7:124531370 G/A cg23710748 chr7:124431027 NA 0.37 5.68 0.3 2.95e-8 Cutaneous malignant melanoma; CRC cis rs10504229 0.683 rs57866073 chr8:58139138 A/G cg21724239 chr8:58056113 NA 0.54 7.23 0.37 3.34e-12 Developmental language disorder (linguistic errors); CRC cis rs2637266 0.600 rs11001833 chr10:78356913 T/G cg18941641 chr10:78392320 NA -0.37 -6.22 -0.32 1.49e-9 Pulmonary function; CRC cis rs4862750 0.914 rs11945845 chr4:187874136 T/C cg03647317 chr4:187891568 NA -0.54 -9.99 -0.48 1.07e-20 Lobe attachment (rater-scored or self-reported); CRC cis rs2354432 0.607 rs6658763 chr1:146692373 C/T cg25205988 chr1:146714368 CHD1L -1.11 -9.13 -0.45 7.11e-18 Mitochondrial DNA levels; CRC cis rs7215564 0.818 rs756076 chr17:78662918 A/G cg09596252 chr17:78655493 RPTOR 0.54 6.08 0.32 3.26e-9 Myopia (pathological); CRC cis rs8010715 0.816 rs11574503 chr14:24601318 C/G cg23112188 chr14:24563095 PCK2 0.36 7.0 0.36 1.42e-11 IgG glycosylation; CRC cis rs7927592 0.956 rs7104877 chr11:68377602 G/T cg01657329 chr11:68192670 LRP5 0.48 7.18 0.37 4.73e-12 Total body bone mineral density; CRC cis rs11249608 0.548 rs10479519 chr5:178450693 T/C cg01312482 chr5:178451176 ZNF879 -0.36 -6.0 -0.31 5.09e-9 Pubertal anthropometrics; CRC cis rs870825 0.655 rs6845058 chr4:185653696 G/A cg04058563 chr4:185651563 MLF1IP -0.77 -9.24 -0.45 3.06e-18 Blood protein levels; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg08664652 chr17:28804287 GOSR1 0.43 6.15 0.32 2.26e-9 Response to antipsychotic treatment; CRC cis rs1552244 0.938 rs56274701 chr3:10167790 G/A cg10729496 chr3:10149963 C3orf24 0.5 6.49 0.34 3.18e-10 Alzheimer's disease; CRC cis rs9992667 0.955 rs1491199 chr4:38643014 G/A cg19726192 chr4:38663646 FLJ13197 -0.66 -8.66 -0.43 2.21e-16 Eosinophil percentage of granulocytes; CRC cis rs11212617 1.000 rs573890 chr11:108251363 C/G cg12106634 chr11:108092400 ATM;NPAT -0.39 -5.79 -0.3 1.6e-8 Response to metformin in type 2 diabetes (glycemic); CRC cis rs6502050 0.736 rs12150322 chr17:80061582 T/G cg22110888 chr17:80059540 CCDC57 -0.42 -6.54 -0.34 2.37e-10 Life satisfaction; CRC trans rs208520 0.526 rs7775830 chr6:66755249 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 1.1 21.42 0.76 2.32e-64 Exhaled nitric oxide output; CRC cis rs28386778 0.799 rs2727322 chr17:61921706 G/A cg23090583 chr17:61904693 PSMC5;FTSJ3 1.03 20.18 0.74 1.67e-59 Prudent dietary pattern; CRC cis rs12550646 0.625 rs1549064 chr8:41684488 A/C cg12180191 chr8:41686706 ANK1 -0.46 -6.62 -0.34 1.44e-10 Reticulocyte fraction of red cells;Reticulocyte count; CRC cis rs908922 0.676 rs4112786 chr1:152532872 T/A cg23254163 chr1:152506842 NA 0.45 9.14 0.45 6.46e-18 Hair morphology; CRC cis rs6952808 0.635 rs12154473 chr7:1982181 A/G cg21782813 chr7:2030301 MAD1L1 -0.44 -8.03 -0.4 1.77e-14 Bipolar disorder and schizophrenia; CRC cis rs55702914 0.809 rs2376407 chr2:198183465 A/G cg20885578 chr2:198174922 NA -0.33 -5.72 -0.3 2.36e-8 Major depression and alcohol dependence; CRC cis rs10927875 0.894 rs34957618 chr1:16320499 G/C cg10494257 chr1:16342123 HSPB7 -0.43 -5.79 -0.3 1.67e-8 Dilated cardiomyopathy; CRC cis rs9435341 0.965 rs61798468 chr1:107569316 T/G cg14671364 chr1:107599128 PRMT6 0.55 7.41 0.38 1.1e-12 Facial morphology (factor 21, depth of nasal alae); CRC cis rs6499255 0.951 rs56282083 chr16:69825728 C/T cg15192750 chr16:69999425 NA 0.56 7.27 0.37 2.67e-12 IgE levels; CRC cis rs501120 0.584 rs661697 chr10:44740698 G/T cg09554077 chr10:44749378 NA 0.75 8.3 0.42 2.76e-15 Coronary artery disease;Coronary heart disease; CRC cis rs7945705 0.846 rs2742540 chr11:8899528 A/G cg14711859 chr11:8959438 ASCL3 -0.43 -7.19 -0.37 4.35e-12 Hemoglobin concentration; CRC trans rs916888 0.773 rs538628 chr17:44787313 G/C cg01341218 chr17:43662625 NA 0.99 10.33 0.49 7.55e-22 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs66573146 1.000 rs66712119 chr4:6965428 A/T cg00086871 chr4:6988644 TBC1D14 1.01 7.58 0.39 3.49e-13 Granulocyte percentage of myeloid white cells; CRC cis rs911555 0.755 rs4143998 chr14:103955247 T/C cg12935359 chr14:103987150 CKB -0.55 -9.17 -0.45 5.26e-18 Intelligence (multi-trait analysis); CRC cis rs853679 0.760 rs967005 chr6:28210688 C/T cg03623178 chr6:28175578 NA 0.74 7.82 0.4 7.43e-14 Depression; CRC trans rs66573146 0.572 rs66819208 chr4:6946128 A/G cg07817883 chr1:32538562 TMEM39B 1.1 11.79 0.54 5.31e-27 Granulocyte percentage of myeloid white cells; CRC cis rs1448094 0.511 rs59858864 chr12:86166404 G/A cg19622623 chr12:86230825 RASSF9 -0.39 -5.98 -0.31 5.91e-9 Major depressive disorder; CRC cis rs1559088 0.847 rs10416265 chr19:33605300 A/G cg27124370 chr19:33622961 WDR88 0.41 5.68 0.3 2.96e-8 Bone ultrasound measurement (broadband ultrasound attenuation); CRC cis rs769267 0.929 rs2905424 chr19:19473445 T/C cg02546618 chr19:19431379 KIAA0892;SF4 -0.48 -6.55 -0.34 2.24e-10 Tonsillectomy; CRC cis rs2836974 0.897 rs2836925 chr21:40532353 T/C cg11644478 chr21:40555479 PSMG1 0.8 12.62 0.57 4.88e-30 Cognitive function; CRC cis rs6598955 0.671 rs10902727 chr1:26597781 C/T cg04990556 chr1:26633338 UBXN11 0.53 5.73 0.3 2.23e-8 Obesity-related traits; CRC cis rs7618915 0.547 rs12496476 chr3:52708737 A/G cg11645453 chr3:52864694 ITIH4 0.37 6.41 0.33 4.91e-10 Bipolar disorder; CRC cis rs4713118 0.662 rs149947 chr6:27972433 A/T cg02631126 chr6:28058918 ZSCAN12L1 0.26 5.84 0.31 1.26e-8 Parkinson's disease; CRC cis rs1065852 0.526 rs11090066 chr22:42398195 A/G cg22189786 chr22:42395067 WBP2NL 0.42 6.32 0.33 8.47e-10 Response to serotonin reuptake inhibitors in major depressive disorder (plasma drug and metabolite levels); CRC cis rs4423214 0.840 rs1792229 chr11:71179395 A/G cg13043300 chr11:71146211 DHCR7 -0.43 -5.75 -0.3 2.09e-8 Vitamin D levels; CRC trans rs2567519 0.710 rs2714012 chr17:70783757 C/T cg05377417 chr17:59940892 BRIP1 0.41 6.16 0.32 2.08e-9 Smoking initiation; CRC cis rs6952808 0.723 rs1107592 chr7:2041432 C/T cg00106254 chr7:1943704 MAD1L1 0.45 6.78 0.35 5.55e-11 Bipolar disorder and schizophrenia; CRC cis rs4862750 0.872 rs6811837 chr4:187898162 G/A cg03452623 chr4:187889614 NA -0.92 -21.62 -0.77 3.92e-65 Lobe attachment (rater-scored or self-reported); CRC trans rs7395662 0.591 rs7482521 chr11:48609735 G/A cg15704280 chr7:45808275 SEPT13 -0.48 -6.72 -0.35 7.92e-11 HDL cholesterol; CRC cis rs11123170 0.529 rs112692022 chr2:113970182 C/T cg21550016 chr2:113992930 PAX8;LOC440839;LOC654433 0.52 6.15 0.32 2.26e-9 Renal function-related traits (BUN); CRC cis rs853679 0.517 rs9380058 chr6:28127444 T/C cg02683197 chr6:28174875 NA 0.88 10.83 0.51 1.42e-23 Depression; CRC cis rs34779708 0.900 rs73262807 chr10:35496386 C/T cg03585969 chr10:35415529 CREM 0.55 7.4 0.38 1.17e-12 Inflammatory bowel disease;Crohn's disease; CRC cis rs7945718 0.621 rs6485992 chr11:12697359 C/T cg25843174 chr11:12811716 TEAD1 0.42 7.75 0.39 1.13e-13 Educational attainment (years of education); CRC cis rs4713118 0.515 rs9368549 chr6:28050047 T/A cg03623178 chr6:28175578 NA 0.92 12.19 0.56 1.91e-28 Parkinson's disease; CRC cis rs12760731 0.623 rs3791026 chr1:178343890 G/A cg00404053 chr1:178313656 RASAL2 0.73 9.34 0.46 1.48e-18 Obesity-related traits; CRC cis rs67311347 1.000 rs12108041 chr3:40487535 C/T cg09455208 chr3:40491958 NA 0.48 9.58 0.47 2.46e-19 Renal cell carcinoma; CRC trans rs1005277 0.579 rs1740747 chr10:38520465 G/A cg27523141 chr10:43048294 ZNF37B 0.47 6.9 0.36 2.69e-11 Extrinsic epigenetic age acceleration; CRC cis rs875971 0.798 rs7789615 chr7:65878661 A/G cg12463550 chr7:65579703 CRCP 0.48 6.52 0.34 2.72e-10 Aortic root size; CRC cis rs6963495 0.818 rs1721498 chr7:105178819 A/C cg13798780 chr7:105162888 PUS7 -0.42 -5.69 -0.3 2.78e-8 Bipolar disorder (body mass index interaction); CRC cis rs7552404 0.765 rs1251078 chr1:76189488 C/G cg22875332 chr1:76189707 ACADM -0.78 -13.35 -0.59 9.09e-33 Blood metabolite levels;Acylcarnitine levels; CRC cis rs12760731 0.720 rs1510266 chr1:178346771 A/T cg00404053 chr1:178313656 RASAL2 -0.81 -9.81 -0.48 4.31e-20 Obesity-related traits; CRC cis rs4700695 1.000 rs4700696 chr5:65412634 G/C cg21114390 chr5:65439923 SFRS12 -0.61 -6.93 -0.36 2.27e-11 Facial morphology (factor 19); CRC cis rs1153858 0.943 rs12439575 chr15:45684816 T/G cg21132104 chr15:45694354 SPATA5L1 0.6 8.66 0.43 2.15e-16 Homoarginine levels; CRC cis rs2415984 0.579 rs12185007 chr14:46976217 G/A cg14871534 chr14:47121158 RPL10L -0.39 -5.81 -0.31 1.46e-8 Number of children ever born; CRC cis rs477895 0.653 rs72918475 chr11:63878644 G/C cg04317338 chr11:64019027 PLCB3 0.58 6.77 0.35 5.92e-11 Mean platelet volume; CRC cis rs2075371 0.897 rs1643033 chr7:134004662 T/C cg20476274 chr7:133979776 SLC35B4 0.71 12.24 0.56 1.24e-28 Mean platelet volume; CRC cis rs990171 0.913 rs6729638 chr2:102996022 C/T cg03938978 chr2:103052716 IL18RAP 0.46 5.82 0.31 1.37e-8 Lymphocyte counts; CRC cis rs4555082 1.000 rs7146643 chr14:105757392 A/G cg13114125 chr14:105738426 BRF1 -0.69 -10.62 -0.51 7.57e-23 Mean platelet volume;Platelet distribution width; CRC cis rs875971 0.545 rs1796219 chr7:66110964 A/G cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.62 -7.78 -0.39 9.51e-14 Aortic root size; CRC cis rs3804749 0.966 rs2278668 chr3:122835232 T/C cg26084141 chr3:122786895 PDIA5 0.24 6.51 0.34 2.88e-10 Plateletcrit;Mean platelet volume;Platelet count;Platelet distribution width; CRC cis rs11785693 0.862 rs17435835 chr8:5000713 C/T cg26367366 chr8:4980734 NA -0.82 -10.1 -0.49 4.65e-21 Neuroticism (multi-trait analysis);Neuroticism; CRC cis rs7223966 1.000 rs9899491 chr17:61934384 G/C cg05941027 chr17:61774174 LIMD2 0.33 5.88 0.31 1.02e-8 Hip circumference adjusted for BMI;Body mass index; CRC cis rs9368481 0.502 rs3933232 chr6:26877446 T/C cg18278486 chr6:26987575 LOC100270746;C6orf41 0.39 6.06 0.32 3.76e-9 Autism spectrum disorder or schizophrenia; CRC cis rs9311474 0.508 rs4687546 chr3:52605943 T/A cg18404041 chr3:52824283 ITIH1 -0.41 -8.69 -0.43 1.71e-16 Electroencephalogram traits; CRC cis rs12369635 1.000 rs12369635 chr12:129561356 C/T cg01909103 chr12:129572610 TMEM132D -0.69 -6.49 -0.34 3.08e-10 Schizophrenia (inflammation and infection response interaction); CRC cis rs2797160 0.935 rs1739379 chr6:126012593 T/C cg05901451 chr6:126070800 HEY2 0.4 6.12 0.32 2.71e-9 Endometrial cancer; CRC trans rs800082 1.000 rs7613909 chr3:144308606 A/G cg24215973 chr2:240111563 HDAC4 0.54 7.66 0.39 2.16e-13 Smoking behavior; CRC cis rs7705042 0.833 rs12653848 chr5:141489853 A/G cg07392085 chr5:141489673 NDFIP1 -0.43 -5.9 -0.31 9.2e-9 Asthma; CRC cis rs62064224 0.714 rs16967266 chr17:30632274 G/A cg12855166 chr17:30846586 MYO1D -0.4 -6.64 -0.34 1.28e-10 Schizophrenia; CRC cis rs4964805 0.594 rs9132 chr12:104166243 C/T cg02344784 chr12:104178138 NT5DC3 0.47 7.23 0.37 3.35e-12 Attention deficit hyperactivity disorder; CRC cis rs6918586 0.681 rs198831 chr6:26116996 T/C cg18357526 chr6:26021779 HIST1H4A -0.48 -7.18 -0.37 4.55e-12 Schizophrenia; CRC trans rs2303319 0.504 rs961421 chr2:162626099 G/C cg22988483 chr14:93581567 ITPK1 -0.66 -6.08 -0.32 3.32e-9 Cognitive function; CRC cis rs9368481 0.761 rs9357028 chr6:26967224 T/G cg07220782 chr6:26987966 LOC100270746;C6orf41 -0.41 -5.8 -0.3 1.59e-8 Autism spectrum disorder or schizophrenia; CRC cis rs71403859 0.502 rs34380814 chr16:71488175 C/T cg08717414 chr16:71523259 ZNF19 -0.68 -7.96 -0.4 2.78e-14 Post bronchodilator FEV1; CRC cis rs8060686 0.565 rs4359427 chr16:68202747 C/T cg08314208 chr16:67682810 RLTPR -0.47 -5.69 -0.3 2.75e-8 HDL cholesterol;Metabolic syndrome; CRC cis rs2439831 0.681 rs28594657 chr15:43588888 C/A cg02155558 chr15:43621948 ADAL;LCMT2 0.79 7.52 0.38 5.39e-13 Lung cancer in ever smokers; CRC cis rs9287719 0.649 rs12473957 chr2:10717714 C/G cg00105475 chr2:10696890 NA -0.45 -7.08 -0.36 8.89e-12 Prostate cancer; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg04245373 chr16:71392615 CALB2 0.39 6.0 0.31 5.32e-9 Intelligence (multi-trait analysis); CRC cis rs11098499 0.908 rs28499576 chr4:120386677 G/A cg09307838 chr4:120376055 NA 0.71 11.06 0.52 2.18e-24 Corneal astigmatism; CRC cis rs6662572 0.737 rs56368769 chr1:46451739 A/G cg03123370 chr1:45965343 CCDC163P;MMACHC 0.45 5.64 0.3 3.59e-8 Blood protein levels; CRC trans rs11098499 1.000 rs11098500 chr4:120219239 T/A cg25214090 chr10:38739885 LOC399744 0.52 7.91 0.4 4.05e-14 Corneal astigmatism; CRC cis rs9322193 0.962 rs9689269 chr6:150112997 G/A cg07701084 chr6:150067640 NUP43 0.47 6.61 0.34 1.51e-10 Lung cancer; CRC cis rs798554 0.660 rs1182175 chr7:2875026 C/T cg13628971 chr7:2884303 GNA12 -0.37 -5.91 -0.31 8.55e-9 Height; CRC cis rs9549328 0.731 rs7983602 chr13:113620482 A/G cg24588162 chr13:113633484 MCF2L -0.41 -7.39 -0.38 1.23e-12 Systolic blood pressure; CRC trans rs7615952 0.512 rs2979336 chr3:125357470 G/A cg17147758 chr8:6949321 NA -0.5 -6.95 -0.36 1.94e-11 Blood pressure (smoking interaction); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg00946381 chr16:2205241 TRAF7;SNORD60 0.46 6.31 0.33 8.82e-10 Response to antipsychotic treatment; CRC cis rs13315871 0.929 rs4560319 chr3:58386274 C/T cg20936604 chr3:58311152 NA -0.72 -6.7 -0.35 9.26e-11 Cholesterol, total; CRC cis rs73206853 0.764 rs7312139 chr12:110985442 C/A cg12870014 chr12:110450643 ANKRD13A 0.8 9.2 0.45 4.16e-18 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC trans rs4684776 0.606 rs12632336 chr3:11663307 G/A cg20302342 chr1:156215951 PAQR6 -0.45 -6.02 -0.31 4.6e-9 Small vessel stroke; CRC cis rs3741151 0.656 rs112699563 chr11:73015243 C/T cg17517138 chr11:73019481 ARHGEF17 0.68 7.23 0.37 3.39e-12 GIP levels in response to oral glucose tolerance test (120 minutes); CRC cis rs7412746 0.658 rs8444 chr1:150938571 G/A cg18016565 chr1:150552671 MCL1 0.43 6.16 0.32 2.15e-9 Melanoma; CRC cis rs5753618 0.509 rs5753500 chr22:31578879 A/G cg22777020 chr22:31556080 RNF185 -0.52 -6.12 -0.32 2.6e-9 Colorectal cancer; CRC cis rs10911363 0.592 rs10911354 chr1:183489278 G/A cg09173681 chr1:183549694 NCF2 0.75 10.37 0.5 5.35e-22 Systemic lupus erythematosus; CRC cis rs2241584 0.507 rs2913897 chr5:175921783 A/G cg24735937 chr5:175843923 CLTB -0.4 -6.36 -0.33 6.74e-10 Menopause (age at onset); CRC cis rs12458462 0.892 rs2007483 chr18:77476131 A/T cg11879182 chr18:77439856 CTDP1 0.72 11.35 0.53 1.96e-25 Monocyte count; CRC trans rs11098499 0.697 rs6832410 chr4:120296800 A/G cg25214090 chr10:38739885 LOC399744 0.62 9.74 0.47 7.35e-20 Corneal astigmatism; CRC cis rs4692589 1.000 rs4519759 chr4:170933919 T/C cg19918862 chr4:170955249 NA 0.38 6.22 0.32 1.48e-9 Anxiety disorder; CRC cis rs929354 0.739 rs12533082 chr7:157014172 T/A cg17757837 chr7:157058334 UBE3C 0.76 12.9 0.58 4.36e-31 Body mass index; CRC cis rs7737355 0.947 rs7720339 chr5:130837134 T/C cg06307176 chr5:131281290 NA 0.42 6.16 0.32 2.11e-9 Life satisfaction; CRC cis rs713477 0.967 rs6573029 chr14:55913550 A/C cg13175173 chr14:55914753 NA -0.48 -9.13 -0.45 7.34e-18 Pediatric bone mineral content (femoral neck); CRC cis rs9814567 1.000 rs3846056 chr3:134227292 A/G cg06109529 chr3:134205091 CEP63;ANAPC13 -0.81 -12.26 -0.56 1e-28 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs6912958 0.781 rs3918467 chr6:88180388 C/G cg12350822 chr6:88032061 C6orf162;GJB7 -0.32 -6.22 -0.32 1.53e-9 Monocyte percentage of white cells; CRC cis rs7412746 0.658 rs6658066 chr1:150918937 T/G cg10589385 chr1:150898437 SETDB1 0.29 6.21 0.32 1.6e-9 Melanoma; CRC cis rs3749237 0.555 rs2117939 chr3:49415179 C/A cg07636037 chr3:49044803 WDR6 0.54 7.84 0.4 6.25e-14 Resting heart rate; CRC cis rs524281 1.000 rs524281 chr11:65886662 C/A cg16950941 chr11:66035639 RAB1B 0.63 8.95 0.44 2.65e-17 Electroencephalogram traits; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg07917886 chr7:156793362 NA 0.4 6.56 0.34 2.14e-10 Liver disease severity in Alagille syndrome; CRC cis rs12476592 0.602 rs166385 chr2:63888023 T/A cg10828910 chr2:63850056 LOC388955 0.51 6.44 0.33 4.22e-10 Childhood ear infection; CRC cis rs7615952 0.599 rs1875683 chr3:125732481 C/G cg05084668 chr3:125655381 ALG1L -0.47 -6.64 -0.34 1.32e-10 Blood pressure (smoking interaction); CRC cis rs7127900 0.614 rs72853920 chr11:2206429 T/C cg20200711 chr11:2211776 NA -0.47 -6.5 -0.34 3.05e-10 Prostate cancer;Prostate cancer (SNP x SNP interaction);Prostate cancer (early onset); CRC cis rs10751667 0.666 rs7934963 chr11:957220 C/T ch.11.42038R chr11:967971 AP2A2 0.6 10.28 0.49 1.13e-21 Alzheimer's disease (late onset); CRC cis rs5769765 0.817 rs11912619 chr22:50317401 G/A cg22709217 chr22:50311962 ALG12;CRELD2 -1.04 -14.88 -0.63 1.22e-38 Schizophrenia; CRC cis rs9311474 0.935 rs7622851 chr3:52333671 C/G cg15147215 chr3:52552868 STAB1 -0.66 -11.52 -0.54 5.16e-26 Electroencephalogram traits; CRC cis rs12230513 0.732 rs61956300 chr12:55812640 T/G cg19537932 chr12:55886519 OR6C68 -0.75 -9.64 -0.47 1.53e-19 Contrast sensitivity; CRC cis rs10504229 0.639 rs17331850 chr8:58113538 G/T cg24829409 chr8:58192753 C8orf71 -0.54 -7.88 -0.4 4.9e-14 Developmental language disorder (linguistic errors); CRC cis rs4713118 0.621 rs4713133 chr6:28034041 T/C cg21251018 chr6:28226885 NKAPL 0.47 6.38 0.33 6.15e-10 Parkinson's disease; CRC cis rs9308731 0.623 rs2241844 chr2:111879364 C/T cg18646521 chr2:111875858 NA 0.39 6.12 0.32 2.7e-9 Chronic lymphocytic leukemia; CRC cis rs2302190 0.882 rs9911609 chr17:56673087 T/C cg12560992 chr17:57184187 TRIM37 0.53 6.17 0.32 1.98e-9 Vitamin D levels; CRC cis rs2440129 0.632 rs2292353 chr17:6903537 C/T cg03404566 chr17:6899310 ALOX12 0.62 11.2 0.53 6.91e-25 Tonsillectomy; CRC cis rs780096 0.546 rs1528533 chr2:27595756 G/C cg12648201 chr2:27665141 KRTCAP3 -0.3 -6.01 -0.31 4.88e-9 Total body bone mineral density; CRC cis rs1799949 1.000 rs2037076 chr17:41305883 G/A cg25072359 chr17:41440525 NA 0.46 7.0 0.36 1.42e-11 Menopause (age at onset); CRC cis rs1799949 1.000 rs33920795 chr17:41329010 A/G cg01879757 chr17:41196368 BRCA1 -0.43 -6.62 -0.34 1.51e-10 Menopause (age at onset); CRC cis rs7552404 0.924 rs1146574 chr1:76202671 A/G cg10523679 chr1:76189770 ACADM 0.77 11.7 0.54 1.16e-26 Blood metabolite levels;Acylcarnitine levels; CRC cis rs7615952 0.641 rs6438951 chr3:125696999 A/G cg18479299 chr3:125709523 NA -0.51 -6.25 -0.33 1.29e-9 Blood pressure (smoking interaction); CRC cis rs10256972 0.616 rs4998392 chr7:1113344 A/C cg23978390 chr7:1156363 C7orf50 0.43 5.98 0.31 5.87e-9 Longevity;Endometriosis; CRC cis rs12048904 0.595 rs10493937 chr1:101342650 A/T cg15686842 chr1:101360669 SLC30A7;EXTL2 -0.45 -6.25 -0.33 1.29e-9 Multiple sclerosis; CRC cis rs9733 0.715 rs7534124 chr1:150739073 C/T cg17724175 chr1:150552817 MCL1 -0.38 -5.85 -0.31 1.22e-8 Tonsillectomy; CRC cis rs11758351 0.866 rs75091077 chr6:26207546 A/C cg22723502 chr6:26240528 HIST1H4F -0.38 -6.35 -0.33 7.27e-10 Gout;Renal underexcretion gout; CRC cis rs7178572 0.633 rs4886877 chr15:77838535 C/G cg22256960 chr15:77711686 NA -0.63 -8.72 -0.43 1.38e-16 Type 2 diabetes; CRC cis rs4731207 0.596 rs6466979 chr7:124648029 T/A cg23710748 chr7:124431027 NA -0.39 -6.25 -0.33 1.24e-9 Cutaneous malignant melanoma; CRC cis rs2070997 0.938 rs6597644 chr9:133744911 C/T cg01000188 chr9:133769184 QRFP 0.53 6.87 0.35 3.22e-11 Response to amphetamines; CRC cis rs875971 0.508 rs10242423 chr7:66059175 A/G cg18876405 chr7:65276391 NA -0.59 -10.62 -0.51 7.43e-23 Aortic root size; CRC cis rs6088580 0.634 rs3746455 chr20:32957216 G/A cg08999081 chr20:33150536 PIGU -0.61 -11.3 -0.53 3e-25 Glomerular filtration rate (creatinine); CRC cis rs1797081 0.934 rs1797077 chr10:16853252 C/T cg23933602 chr10:16859644 RSU1 1.05 21.14 0.76 2.96e-63 Platelet distribution width; CRC cis rs10979 0.965 rs9496674 chr6:143886106 G/T cg25407410 chr6:143891975 LOC285740 -0.81 -13.19 -0.59 3.42e-32 Hypospadias; CRC cis rs7605378 1.000 rs769958 chr2:200695901 G/A cg23649088 chr2:200775458 C2orf69 0.6 8.4 0.42 1.32e-15 Osteoporosis; CRC cis rs7666738 0.830 rs732299 chr4:98995389 C/T cg05340658 chr4:99064831 C4orf37 0.58 8.94 0.44 2.79e-17 Colonoscopy-negative controls vs population controls; CRC cis rs7289126 1.000 rs5750571 chr22:38640312 A/G cg25457927 chr22:38595422 NA -0.32 -6.16 -0.32 2.07e-9 Mammographic density (dense area);Percent mammographic density; CRC cis rs8180040 0.764 rs11718795 chr3:47218727 G/A cg27129171 chr3:47204927 SETD2 0.68 11.14 0.52 1.13e-24 Colorectal cancer; CRC cis rs910316 0.967 rs175451 chr14:75589729 C/T cg03030879 chr14:75389066 RPS6KL1 0.46 7.3 0.37 2.14e-12 Height; CRC trans rs800082 0.516 rs9852425 chr3:144215405 A/C cg24215973 chr2:240111563 HDAC4 0.44 6.01 0.31 4.96e-9 Smoking behavior; CRC cis rs2153535 0.580 rs6905237 chr6:8471790 A/T cg21535247 chr6:8435926 SLC35B3 0.51 7.77 0.39 9.8e-14 Motion sickness; CRC cis rs7394190 0.935 rs12570126 chr10:75416789 C/T cg07699608 chr10:75541558 CHCHD1 -0.52 -6.05 -0.32 3.99e-9 Incident atrial fibrillation; CRC cis rs2836974 0.644 rs9978775 chr21:40694526 A/G cg11644478 chr21:40555479 PSMG1 -0.62 -9.23 -0.45 3.37e-18 Cognitive function; CRC cis rs801193 0.839 rs6968619 chr7:66068867 T/C cg00343986 chr7:65444356 GUSB -0.48 -7.11 -0.36 7.48e-12 Aortic root size; CRC cis rs3736485 0.966 rs12441167 chr15:51850652 T/C cg08986416 chr15:51914746 DMXL2 -0.45 -6.52 -0.34 2.72e-10 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs1552244 0.935 rs41520445 chr3:10153141 A/C cg13047869 chr3:10149882 C3orf24 -0.58 -7.9 -0.4 4.34e-14 Alzheimer's disease; CRC cis rs13108904 0.901 rs12509700 chr4:1296321 A/G cg15763984 chr4:1342303 KIAA1530 0.36 6.25 0.33 1.29e-9 Obesity-related traits; CRC cis rs9547692 1.000 rs9547691 chr13:37468588 T/C cg01493522 chr13:37497338 NA -0.53 -7.2 -0.37 4.01e-12 Coronary artery disease; CRC cis rs79839061 0.562 rs10516158 chr4:942439 A/G cg14530993 chr4:882597 GAK -0.81 -7.52 -0.38 5.42e-13 Intelligence (multi-trait analysis); CRC cis rs2204008 0.720 rs11181343 chr12:38323616 G/T cg26384229 chr12:38710491 ALG10B 0.69 9.71 0.47 9.43e-20 Bladder cancer; CRC cis rs910316 0.789 rs4899552 chr14:75667921 C/A cg08847533 chr14:75593920 NEK9 -0.78 -12.58 -0.57 6.48e-30 Height; CRC cis rs902774 0.530 rs11834907 chr12:53350985 C/T cg14581129 chr12:53358946 NA -0.91 -8.8 -0.44 7.98e-17 Prostate cancer; CRC cis rs12701220 0.894 rs34712249 chr7:1036634 C/T cg26769984 chr7:1090371 C7orf50 0.68 9.04 0.45 1.43e-17 Bronchopulmonary dysplasia; CRC cis rs9868809 0.505 rs13316551 chr3:48745167 A/C cg00383909 chr3:49044727 WDR6 0.76 7.71 0.39 1.55e-13 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; CRC cis rs7580658 0.963 rs12479003 chr2:128118553 C/T cg09760422 chr2:128146352 NA -0.36 -6.89 -0.36 2.84e-11 Protein C levels; CRC cis rs3812762 1.000 rs3812762 chr11:8751640 C/G cg21881798 chr11:8931708 C11orf17;ST5 -0.38 -5.63 -0.3 3.89e-8 Hypospadias; CRC cis rs1519814 0.736 rs7822384 chr8:121071789 A/G cg22335954 chr8:121166405 COL14A1 -0.59 -6.18 -0.32 1.91e-9 Breast cancer; CRC cis rs7945705 0.902 rs2016942 chr11:8938787 A/G cg00186954 chr11:8933980 ST5;C11orf17 0.45 6.9 0.36 2.72e-11 Hemoglobin concentration; CRC cis rs4363385 0.747 rs4255332 chr1:152958745 G/C cg25856811 chr1:152973957 SPRR3 -0.27 -7.45 -0.38 8.07e-13 Inflammatory skin disease; CRC cis rs68170813 0.523 rs12154285 chr7:106993573 G/A cg02696742 chr7:106810147 HBP1 -0.56 -6.09 -0.32 3.13e-9 Coronary artery disease; CRC cis rs1448094 0.511 rs4559760 chr12:86149414 G/A cg25456477 chr12:86230367 RASSF9 -0.36 -6.07 -0.32 3.43e-9 Major depressive disorder; CRC cis rs13098911 0.540 rs61650989 chr3:46054156 G/T cg12691230 chr3:46064611 XCR1 -0.52 -5.81 -0.3 1.51e-8 Celiac disease; CRC cis rs8060686 0.844 rs3785100 chr16:67997920 T/C cg19582491 chr16:67682965 RLTPR -0.58 -6.54 -0.34 2.29e-10 HDL cholesterol;Metabolic syndrome; CRC cis rs1218582 0.741 rs10908446 chr1:154869559 G/A cg24250549 chr1:154909240 PMVK 0.65 11.13 0.52 1.27e-24 Prostate cancer; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg14797243 chr11:68671428 IGHMBP2;MRPL21 0.5 6.71 0.35 8.37e-11 Thyroid stimulating hormone; CRC cis rs4635969 0.718 rs27071 chr5:1346081 T/C cg06550200 chr5:1325588 CLPTM1L -0.54 -6.96 -0.36 1.87e-11 Testicular germ cell tumor;Testicular germ cell cancer; CRC cis rs35306767 0.903 rs12769873 chr10:936526 G/T cg20503657 chr10:835505 NA 0.94 11.58 0.54 3.16e-26 Eosinophil percentage of granulocytes; CRC cis rs17376456 0.877 rs9314095 chr5:93425495 T/C cg09848695 chr5:92956644 FAM172A;MIR2277 0.63 5.83 0.31 1.29e-8 Diabetic retinopathy; CRC cis rs908922 0.676 rs11584191 chr1:152500428 A/T cg23254163 chr1:152506842 NA -0.45 -8.84 -0.44 5.88e-17 Hair morphology; CRC cis rs7680126 0.596 rs10489070 chr4:10276352 C/G cg00071950 chr4:10020882 SLC2A9 -0.46 -6.1 -0.32 2.99e-9 Urate levels in lean individuals;Urate levels in overweight individuals;Urate levels in obese individuals; CRC cis rs1707322 1.000 rs10890355 chr1:46317348 G/A cg06784218 chr1:46089804 CCDC17 0.51 9.03 0.45 1.45e-17 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC trans rs9393777 0.920 rs13191227 chr6:27390115 G/C cg16898833 chr6:26189333 HIST1H4D 0.95 6.45 0.34 3.99e-10 Intelligence (multi-trait analysis); CRC cis rs524281 0.817 rs7115081 chr11:65853541 A/G cg16950941 chr11:66035639 RAB1B -0.61 -7.66 -0.39 2.1e-13 Electroencephalogram traits; CRC cis rs561341 0.941 rs2428336 chr17:30290577 T/C cg19193384 chr17:30244184 NA -0.54 -6.84 -0.35 3.89e-11 Hip circumference adjusted for BMI; CRC cis rs11083475 0.714 rs7248584 chr19:39258110 C/T cg26703956 chr19:39260304 NA -0.35 -5.72 -0.3 2.4e-8 Heart rate; CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg06700871 chr2:84686330 SUCLG1 0.45 7.01 0.36 1.32e-11 Obesity-related traits; CRC cis rs875971 0.545 rs316305 chr7:65617971 G/A cg02869306 chr7:64672164 INTS4L1 0.43 6.29 0.33 1.04e-9 Aortic root size; CRC cis rs9786986 0.764 rs75753504 chr1:235697380 C/T cg08848088 chr1:235714526 GNG4 0.56 6.57 0.34 1.99e-10 Body mass index; CRC cis rs17095355 1.000 rs57440982 chr10:111735772 G/A cg00817464 chr10:111662876 XPNPEP1 -0.63 -8.33 -0.42 2.18e-15 Biliary atresia; CRC cis rs651907 0.535 rs35799195 chr3:101521927 A/G cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.59 7.86 0.4 5.42e-14 Colorectal cancer; CRC cis rs77688320 0.535 rs6435084 chr2:202325997 T/G cg00712779 chr2:202317602 STRADB;TRAK2 0.38 5.61 0.3 4.23e-8 Breast cancer; CRC cis rs9388451 0.868 rs10457467 chr6:126045148 T/A cg05901451 chr6:126070800 HEY2 -0.66 -11.48 -0.53 7.01e-26 Brugada syndrome; CRC trans rs2727020 0.513 rs10839307 chr11:49609843 A/C cg03929089 chr4:120376271 NA -0.91 -16.99 -0.68 6.51e-47 Coronary artery disease; CRC cis rs9527 0.662 rs4919686 chr10:104592249 A/C cg04362960 chr10:104952993 NT5C2 0.65 8.11 0.41 1.03e-14 Arsenic metabolism; CRC cis rs10504229 0.683 rs67077711 chr8:58139769 G/T cg22535103 chr8:58192502 C8orf71 -0.7 -9.34 -0.46 1.47e-18 Developmental language disorder (linguistic errors); CRC cis rs2066819 1.000 rs77032009 chr12:56679971 A/G cg26714650 chr12:56694279 CS -1.41 -11.64 -0.54 1.88e-26 Psoriasis vulgaris; CRC cis rs8177253 0.574 rs6775042 chr3:133442245 G/T cg24879335 chr3:133465180 TF 0.31 5.88 0.31 9.95e-9 Iron status biomarkers; CRC cis rs9916302 0.808 rs6503515 chr17:37606433 G/T cg03013999 chr17:37608204 MED1 0.45 6.87 0.35 3.15e-11 Glomerular filtration rate (creatinine); CRC cis rs10876993 0.728 rs1082503 chr12:58036717 G/A cg18357645 chr12:58087776 OS9 0.54 7.29 0.37 2.33e-12 Celiac disease or Rheumatoid arthritis; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg24487027 chr10:92923837 NA 0.44 6.04 0.32 4.06e-9 Anxiety disorder; CRC cis rs6951245 0.554 rs35126802 chr7:1134842 C/T cg21664854 chr7:1097933 C7orf50;GPR146 0.57 7.25 0.37 2.91e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs1448094 0.511 rs10779207 chr12:86152913 A/G cg18827107 chr12:86230957 RASSF9 0.39 5.98 0.31 5.76e-9 Major depressive disorder; CRC cis rs116095464 0.558 rs62347677 chr5:227453 A/G cg22857025 chr5:266934 NA -1.18 -15.77 -0.66 3.86e-42 Breast cancer; CRC cis rs6754459 0.666 rs11674266 chr2:3705291 A/G cg10645314 chr2:3704589 ALLC -0.41 -5.62 -0.3 4.13e-8 Response to inhaled corticosteroid treatment in asthma (change in FEV1); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg00924484 chr1:110753232 KCNC4 0.41 6.66 0.34 1.14e-10 Liver disease severity in Alagille syndrome; CRC cis rs4862750 0.957 rs4861733 chr4:187903933 C/T cg27532560 chr4:187881888 NA -0.57 -10.15 -0.49 3.15e-21 Lobe attachment (rater-scored or self-reported); CRC cis rs2019137 0.539 rs4849177 chr2:113982584 T/C cg11763394 chr2:113992921 PAX8;LOC440839;LOC654433 0.65 10.05 0.48 6.59e-21 Lymphocyte counts; CRC cis rs902774 0.530 rs12819597 chr12:53353956 T/C cg14581129 chr12:53358946 NA -0.91 -8.8 -0.44 7.76e-17 Prostate cancer; CRC cis rs10504229 1.000 rs61212428 chr8:58173963 G/A cg05313129 chr8:58192883 C8orf71 -0.47 -6.99 -0.36 1.49e-11 Developmental language disorder (linguistic errors); CRC cis rs3768617 0.510 rs6666259 chr1:183102855 T/C ch.1.3577855R chr1:183094577 LAMC1 0.89 15.63 0.65 1.44e-41 Fuchs's corneal dystrophy; CRC trans rs11250098 0.510 rs4840525 chr8:10765635 C/A cg06636001 chr8:8085503 FLJ10661 -0.51 -7.53 -0.38 4.95e-13 Morning vs. evening chronotype; CRC trans rs2303319 0.504 rs58622044 chr2:162596287 A/G cg21546874 chr1:9294571 H6PD -0.7 -6.03 -0.32 4.44e-9 Cognitive function; CRC cis rs12479064 0.724 rs4851203 chr2:99986932 T/C cg14399236 chr2:99771627 LIPT1;TSGA10 -0.63 -7.84 -0.4 6.53e-14 Chronic sinus infection; CRC cis rs9649213 0.574 rs17436977 chr7:97883459 T/C cg00277769 chr7:97922759 BAIAP2L1 -0.6 -10.15 -0.49 3.03e-21 Prostate cancer (SNP x SNP interaction); CRC cis rs1862618 0.802 rs33327 chr5:56142693 T/G cg18230493 chr5:56204884 C5orf35 -0.72 -9.21 -0.45 4.06e-18 Initial pursuit acceleration; CRC cis rs10791323 0.593 rs10791329 chr11:133716356 T/C cg15485101 chr11:133734466 NA 0.42 7.09 0.36 8.13e-12 Childhood ear infection; CRC cis rs826838 1.000 rs10875717 chr12:38911174 T/C cg26384229 chr12:38710491 ALG10B 0.75 10.44 0.5 3.06e-22 Heart rate; CRC trans rs1569175 0.655 rs3115414 chr2:200913244 A/C cg19477977 chr2:235599692 NA 0.68 6.12 0.32 2.72e-9 Response to treatment for acute lymphoblastic leukemia; CRC cis rs947211 0.898 rs1775146 chr1:205756168 A/G cg11965913 chr1:205819406 PM20D1 0.44 5.98 0.31 5.66e-9 Parkinson's disease; CRC cis rs6693567 0.565 rs698921 chr1:150379517 G/A cg15654264 chr1:150340011 RPRD2 0.44 6.59 0.34 1.7e-10 Migraine; CRC trans rs11343 0.675 rs7359333 chr16:19262344 A/T cg04153890 chr17:47633892 NA -0.5 -6.26 -0.33 1.18e-9 Parkinson's disease; CRC cis rs2979489 0.740 rs17554408 chr8:30427531 A/G cg26383811 chr8:30366931 RBPMS 0.68 10.13 0.49 3.74e-21 Mean corpuscular hemoglobin;Plateletcrit;Neutrophil count;Granulocyte count;Sum basophil neutrophil counts;Mean corpuscular volume;Myeloid white cell count;Sum neutrophil eosinophil counts; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg21159473 chr9:15510228 PSIP1 -0.42 -6.73 -0.35 7.6e-11 Myopia (pathological); CRC cis rs7309 0.622 rs4664396 chr2:161901650 C/T cg22496339 chr2:162101262 NA -0.42 -6.5 -0.34 2.96e-10 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Educational attainment; CRC cis rs950776 0.518 rs3813572 chr15:78832588 T/C cg06917634 chr15:78832804 PSMA4 0.66 10.49 0.5 2.16e-22 Sudden cardiac arrest; CRC cis rs2797160 0.651 rs9491503 chr6:126031682 G/A cg05901451 chr6:126070800 HEY2 0.48 7.72 0.39 1.37e-13 Endometrial cancer; CRC cis rs72627123 0.530 rs79371463 chr14:74474856 T/A cg12022184 chr14:74485813 ENTPD5;C14orf45 0.71 5.81 0.3 1.5e-8 Morning vs. evening chronotype; CRC cis rs262150 0.574 rs2730272 chr7:158798622 G/C cg07130601 chr7:158766826 NA 0.4 5.83 0.31 1.32e-8 Facial morphology (factor 20); CRC cis rs45509595 0.841 rs401754 chr6:27782538 T/A cg19041857 chr6:27730383 NA -0.72 -6.75 -0.35 6.7e-11 Breast cancer; CRC trans rs2832077 1.000 rs2832077 chr21:30141021 G/A cg14791747 chr16:20752902 THUMPD1 0.54 6.94 0.36 2.11e-11 Cognitive test performance; CRC trans rs3780486 0.718 rs10971418 chr9:33122024 A/C cg04842962 chr6:43655489 MRPS18A -0.93 -12.0 -0.55 9.31e-28 IgG glycosylation; CRC cis rs1218582 0.741 rs2335407 chr1:154843347 A/G cg03351412 chr1:154909251 PMVK -0.5 -7.91 -0.4 4.05e-14 Prostate cancer; CRC cis rs55794721 0.509 rs11249248 chr1:25753051 T/C cg23205692 chr1:25664452 TMEM50A 0.41 6.01 0.31 4.99e-9 Plateletcrit;Mean corpuscular volume; CRC cis rs9311676 0.632 rs11130643 chr3:58423288 G/A cg06643156 chr3:58380774 PXK 0.43 6.53 0.34 2.5e-10 Systemic lupus erythematosus; CRC cis rs11212617 1.000 rs637064 chr11:108140909 C/T cg12106634 chr11:108092400 ATM;NPAT 0.42 6.15 0.32 2.31e-9 Response to metformin in type 2 diabetes (glycemic); CRC cis rs7666738 0.830 rs4699601 chr4:99034429 G/A cg05340658 chr4:99064831 C4orf37 0.61 9.43 0.46 7.65e-19 Colonoscopy-negative controls vs population controls; CRC cis rs67311347 1.000 rs9875245 chr3:40442280 G/T cg09455208 chr3:40491958 NA 0.47 8.93 0.44 3.11e-17 Renal cell carcinoma; CRC cis rs17376456 0.569 rs6895356 chr5:93060781 A/G cg21475434 chr5:93447410 FAM172A 0.46 5.82 0.31 1.36e-8 Diabetic retinopathy; CRC cis rs7605827 0.930 rs7587257 chr2:15513256 A/G cg19274914 chr2:15703543 NA 0.39 6.03 0.32 4.34e-9 Educational attainment (years of education); CRC cis rs4843747 0.605 rs28399183 chr16:88107277 G/A cg07865391 chr16:88106882 BANP 0.46 5.91 0.31 8.39e-9 Menopause (age at onset); CRC cis rs2012796 0.743 rs12435764 chr14:81836866 A/C cg02996355 chr14:81879375 NA 0.57 8.83 0.44 6.39e-17 Night sleep phenotypes; CRC cis rs910316 1.000 rs9805979 chr14:75566209 G/A cg08847533 chr14:75593920 NEK9 0.93 17.78 0.7 4.82e-50 Height; CRC cis rs7914558 0.966 rs1971589 chr10:104744406 A/G cg04362960 chr10:104952993 NT5C2 0.63 9.59 0.47 2.35e-19 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs3736485 0.966 rs8028017 chr15:51912708 G/A cg08986416 chr15:51914746 DMXL2 -0.45 -6.38 -0.33 5.86e-10 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs6921919 0.583 rs7764737 chr6:28354615 A/T cg21251018 chr6:28226885 NKAPL 0.41 6.24 0.33 1.35e-9 Autism spectrum disorder or schizophrenia; CRC cis rs540254 0.619 rs1556517 chr1:160771761 C/A cg20255094 chr1:160771763 LY9 0.5 6.36 0.33 6.58e-10 Blood protein levels; CRC cis rs10992471 0.729 rs7042335 chr9:95122547 C/T cg13798575 chr9:95087839 CENPP;NOL8 -0.49 -7.03 -0.36 1.17e-11 Visceral adipose tissue/subcutaneous adipose tissue ratio; CRC cis rs4665809 0.590 rs11552518 chr2:26455127 G/A cg08067268 chr2:26466485 HADHB;HADHA 0.66 8.38 0.42 1.54e-15 Gut microbiome composition (summer); CRC cis rs977987 0.806 rs12599361 chr16:75434973 A/T cg03315344 chr16:75512273 CHST6 0.53 8.71 0.43 1.55e-16 Dupuytren's disease; CRC cis rs8072100 0.727 rs4794052 chr17:45769236 T/C cg08085267 chr17:45401833 C17orf57 -0.44 -6.47 -0.34 3.51e-10 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs17711722 0.640 rs13237956 chr7:65318029 G/A cg18912574 chr7:65842487 NCRNA00174 0.33 5.68 0.3 2.9e-8 Calcium levels; CRC cis rs2243480 1.000 rs160652 chr7:65538431 A/G cg12463550 chr7:65579703 CRCP 0.71 6.62 0.34 1.46e-10 Diabetic kidney disease; CRC trans rs61931739 0.500 rs34703942 chr12:34583776 T/C cg26384229 chr12:38710491 ALG10B -0.61 -8.95 -0.44 2.57e-17 Morning vs. evening chronotype; CRC cis rs1862618 0.713 rs832549 chr5:56183542 C/T cg22800045 chr5:56110881 MAP3K1 0.62 6.64 0.34 1.29e-10 Initial pursuit acceleration; CRC cis rs9517313 0.592 rs11069311 chr13:99202101 G/T cg20487152 chr13:99095054 FARP1 -0.46 -6.71 -0.35 8.74e-11 Neuroticism; CRC cis rs6502050 0.835 rs3935129 chr17:80113381 G/C cg09264619 chr17:80180166 NA -0.34 -5.81 -0.3 1.5e-8 Life satisfaction; CRC trans rs2303319 0.504 rs62187653 chr2:162469128 T/C cg18122310 chr12:50236657 BCDIN3D -0.73 -6.17 -0.32 2.02e-9 Cognitive function; CRC cis rs4979906 1.000 rs7923587 chr10:79453218 C/T cg07817648 chr10:79422355 NA 0.43 5.69 0.3 2.75e-8 Mortality in heart failure; CRC cis rs6534441 0.579 rs10029005 chr4:125451364 A/G cg21609808 chr4:125404261 NA -0.36 -5.79 -0.3 1.69e-8 Major depressive disorder; CRC cis rs7945718 0.591 rs4515952 chr11:12690200 G/A cg25843174 chr11:12811716 TEAD1 0.39 7.17 0.37 5.06e-12 Educational attainment (years of education); CRC cis rs9303401 0.659 rs16943326 chr17:57050365 C/T cg02118635 chr17:56770003 RAD51C;TEX14 0.8 10.24 0.49 1.49e-21 Cognitive test performance; CRC cis rs9549260 0.755 rs2721045 chr13:41162632 T/A cg21288729 chr13:41239152 FOXO1 0.39 5.98 0.31 5.66e-9 Red blood cell count; CRC cis rs10504229 0.593 rs2317990 chr8:58024168 G/T cg22535103 chr8:58192502 C8orf71 -0.53 -6.32 -0.33 8.44e-10 Developmental language disorder (linguistic errors); CRC cis rs17345786 0.906 rs72946021 chr3:101250008 T/G cg12386194 chr3:101231763 SENP7 0.52 6.68 0.35 9.92e-11 Colonoscopy-negative controls vs population controls; CRC cis rs12142240 0.698 rs56909107 chr1:46808224 A/C cg14993813 chr1:46806288 NSUN4 -0.49 -6.22 -0.32 1.5e-9 Menopause (age at onset); CRC cis rs7809950 1.000 rs3801954 chr7:107117048 C/T cg23024343 chr7:107201750 COG5 -0.61 -8.71 -0.43 1.56e-16 Coronary artery disease; CRC trans rs12310956 0.532 rs1589903 chr12:33943019 C/T cg26384229 chr12:38710491 ALG10B 0.52 6.62 0.34 1.48e-10 Morning vs. evening chronotype; CRC trans rs853679 0.545 rs35949109 chr6:28025926 T/C cg06606381 chr12:133084897 FBRSL1 -0.84 -7.65 -0.39 2.21e-13 Depression; CRC cis rs1552244 1.000 rs68067759 chr3:10150535 T/C cg18598329 chr3:10140678 FANCD2;C3orf24 -0.89 -12.04 -0.55 6.36e-28 Alzheimer's disease; CRC trans rs8002861 0.846 rs56408817 chr13:44471983 A/G cg17145862 chr1:211918768 LPGAT1 -0.71 -12.97 -0.58 2.37e-31 Leprosy; CRC cis rs10870270 0.956 rs10430618 chr10:133748996 C/T cg17892150 chr10:133769511 PPP2R2D -0.75 -11.5 -0.54 6.03e-26 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; CRC cis rs748404 0.660 rs2444251 chr15:43788595 A/G cg02155558 chr15:43621948 ADAL;LCMT2 0.52 7.59 0.39 3.29e-13 Lung cancer; CRC cis rs7917772 0.545 rs3934960 chr10:104355275 A/G cg11453585 chr10:104263688 ACTR1A;SUFU -0.83 -14.99 -0.64 4.59e-39 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC cis rs9733 0.519 rs1336899 chr1:150678910 T/C cg10589385 chr1:150898437 SETDB1 0.29 6.17 0.32 2.04e-9 Tonsillectomy; CRC cis rs853679 0.517 rs9368554 chr6:28082711 T/C cg15786705 chr6:28176104 NA 0.76 9.47 0.46 5.57e-19 Depression; CRC cis rs17253792 0.731 rs79483151 chr14:56048851 C/T cg01858014 chr14:56050164 KTN1 -0.88 -7.09 -0.36 8.36e-12 Putamen volume; CRC cis rs2115630 0.755 rs7169629 chr15:85191274 C/G cg09876464 chr15:85330779 ZNF592 -0.37 -6.13 -0.32 2.46e-9 P wave terminal force; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg21767207 chr19:36236454 PSENEN;U2AF1L4 0.44 7.18 0.37 4.65e-12 Liver disease severity in Alagille syndrome; CRC cis rs853679 0.598 rs9380054 chr6:28067537 G/A cg15845792 chr6:28175446 NA 0.99 13.1 0.59 7.48e-32 Depression; CRC trans rs1005277 0.579 rs2505248 chr10:38459097 A/G cg23533926 chr12:111358616 MYL2 -0.52 -7.76 -0.39 1.07e-13 Extrinsic epigenetic age acceleration; CRC cis rs7927771 0.725 rs11039265 chr11:47523214 C/A cg20307385 chr11:47447363 PSMC3 -0.57 -8.04 -0.41 1.65e-14 Subjective well-being; CRC cis rs752010 1.000 rs2077172 chr1:42093340 A/G cg06885757 chr1:42089581 HIVEP3 0.49 8.52 0.43 5.72e-16 Lupus nephritis in systemic lupus erythematosus; CRC cis rs9311474 0.607 rs4687625 chr3:52563718 C/T cg05573699 chr3:52720067 GNL3;PBRM1 -0.39 -5.7 -0.3 2.69e-8 Electroencephalogram traits; CRC cis rs2180341 1.000 rs7453272 chr6:127633959 C/T cg24812749 chr6:127587940 RNF146 -0.94 -12.33 -0.56 5.59e-29 Breast cancer; CRC cis rs910316 1.000 rs175425 chr14:75626131 T/C cg11812906 chr14:75593930 NEK9 -0.61 -9.45 -0.46 6.78e-19 Height; CRC cis rs1707322 0.963 rs10890371 chr1:46390897 T/G cg03146154 chr1:46216737 IPP 0.5 7.04 0.36 1.12e-11 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC trans rs916888 0.773 rs199443 chr17:44819565 C/T cg13957321 chr17:43675089 NA 0.49 6.15 0.32 2.19e-9 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs9443645 0.869 rs7762022 chr6:79502859 C/A cg09184832 chr6:79620586 NA -0.48 -8.99 -0.44 2.01e-17 Intelligence (multi-trait analysis); CRC cis rs2732480 0.538 rs1387259 chr12:48703522 C/T cg04545296 chr12:48745243 ZNF641 -0.34 -5.84 -0.31 1.28e-8 Hemoglobin concentration;Red blood cell count;Hematocrit; CRC cis rs9910055 0.664 rs433610 chr17:42197281 A/G cg16434002 chr17:42200994 HDAC5 0.45 6.09 0.32 3.19e-9 Total body bone mineral density; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg23048660 chr19:45004795 ZNF180 0.35 6.42 0.33 4.63e-10 Liver disease severity in Alagille syndrome; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg12667079 chr6:166796700 BRP44L 0.43 6.35 0.33 7.02e-10 Intelligence (multi-trait analysis); CRC cis rs17270561 0.609 rs4712961 chr6:25727334 C/T cg17691542 chr6:26056736 HIST1H1C 0.73 9.31 0.46 1.82e-18 Iron status biomarkers; CRC cis rs2777491 0.874 rs7161772 chr15:41611066 A/T cg18705301 chr15:41695430 NDUFAF1 -0.7 -11.6 -0.54 2.55e-26 Ulcerative colitis; CRC cis rs11098499 0.866 rs9995136 chr4:120286845 A/G cg09307838 chr4:120376055 NA 0.68 10.53 0.5 1.51e-22 Corneal astigmatism; CRC cis rs7412746 0.658 rs6677420 chr1:150946490 G/A cg15448220 chr1:150897856 SETDB1 0.53 7.46 0.38 7.74e-13 Melanoma; CRC cis rs9611519 0.894 rs8136923 chr22:41470522 G/A cg03806693 chr22:41940476 POLR3H -0.59 -7.59 -0.39 3.22e-13 Neuroticism; CRC cis rs853679 0.569 rs9348798 chr6:28143011 G/A cg06470822 chr6:28175283 NA 1.01 13.28 0.59 1.55e-32 Depression; CRC cis rs2404602 0.532 rs744336 chr15:76674624 T/C cg03037974 chr15:76606532 NA 0.58 9.85 0.48 3.12e-20 Blood metabolite levels; CRC cis rs1670533 0.932 rs4690347 chr4:1057328 A/G cg27284194 chr4:1044797 NA 0.5 6.2 0.32 1.66e-9 Recombination rate (females); CRC cis rs2576037 0.899 rs2576035 chr18:44587654 C/T cg07416455 chr18:44543612 TCEB3CL;KATNAL2 0.49 7.23 0.37 3.41e-12 Personality dimensions; CRC cis rs1577917 0.682 rs1173417 chr6:86403941 C/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A 0.59 8.39 0.42 1.49e-15 Response to antipsychotic treatment; CRC cis rs4147929 0.532 rs4147932 chr19:1064485 C/T cg12082025 chr19:1064218 ABCA7 -0.36 -6.01 -0.31 4.83e-9 Alzheimer's disease (late onset); CRC cis rs4919694 1.000 rs12254254 chr10:104765605 C/T cg04362960 chr10:104952993 NT5C2 1.17 10.93 0.52 6.24e-24 Arsenic metabolism; CRC cis rs644799 1.000 rs651445 chr11:95539122 T/A cg25478527 chr11:95522999 CEP57;FAM76B 0.51 7.69 0.39 1.68e-13 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs2882667 0.931 rs7706391 chr5:138349164 G/A cg09476006 chr5:138032270 NA 0.41 6.59 0.34 1.73e-10 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs6693567 0.526 rs3818978 chr1:150266338 T/A cg15654264 chr1:150340011 RPRD2 -0.39 -5.76 -0.3 1.95e-8 Migraine; CRC cis rs2629540 0.765 rs4962687 chr10:126404141 G/A cg08799069 chr10:126477246 METTL10 -0.54 -7.89 -0.4 4.4e-14 Cocaine dependence; CRC cis rs637571 0.522 rs542332 chr11:65744421 C/T cg26695010 chr11:65641043 EFEMP2 -0.4 -6.04 -0.32 4.2e-9 Eosinophil percentage of white cells; CRC cis rs1707322 0.721 rs28501477 chr1:46199084 A/G cg06784218 chr1:46089804 CCDC17 0.66 12.24 0.56 1.21e-28 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs6700896 0.931 rs11208716 chr1:66158825 C/T cg04111102 chr1:66153794 NA 0.34 5.87 0.31 1.09e-8 C-reactive protein;Mean corpuscular volume;Mean corpuscular hemoglobin; CRC cis rs7493 1.000 rs2299263 chr7:95040411 A/G cg20119798 chr7:94954144 PON1 0.48 6.14 0.32 2.41e-9 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs7249142 0.549 rs12975253 chr19:19279745 A/C cg12558012 chr19:19281197 LOC729991-MEF2B;MEF2B 0.59 9.47 0.46 5.56e-19 IgG glycosylation; CRC cis rs9611565 0.512 rs5758436 chr22:42124265 C/T cg06481639 chr22:41940642 POLR3H 0.52 5.91 0.31 8.37e-9 Vitiligo; CRC cis rs62064224 0.589 rs8069673 chr17:30661250 C/T cg25809561 chr17:30822961 MYO1D -0.53 -9.48 -0.46 5.34e-19 Schizophrenia; CRC cis rs113296370 0.808 rs6717198 chr2:43874398 C/A cg24650394 chr2:43863435 PLEKHH2 0.47 5.9 0.31 9.19e-9 Diabetes in response to antihypertensive drug treatment (treatment strategy interaction); CRC cis rs9649213 0.593 rs6970801 chr7:97925240 T/C cg00277769 chr7:97922759 BAIAP2L1 -0.61 -10.74 -0.51 2.82e-23 Prostate cancer (SNP x SNP interaction); CRC cis rs17270561 0.609 rs9393659 chr6:25731358 T/C cg16482183 chr6:26056742 HIST1H1C 0.83 10.58 0.5 1.07e-22 Iron status biomarkers; CRC trans rs2303319 0.582 rs56094729 chr2:162464835 C/T cg14875682 chr5:52083620 ITGA1;PELO -0.76 -6.16 -0.32 2.13e-9 Cognitive function; CRC cis rs9549367 1.000 rs9549367 chr13:113911532 C/G cg18105134 chr13:113819100 PROZ -0.73 -10.68 -0.51 4.59e-23 Platelet distribution width; CRC cis rs4975709 0.610 rs4975704 chr5:1859807 C/A cg15595755 chr5:1867978 NA 0.36 5.93 0.31 7.72e-9 Cardiovascular disease risk factors; CRC cis rs6502050 0.835 rs9900072 chr17:80114360 C/G cg13198984 chr17:80129470 CCDC57 0.45 8.12 0.41 9.48e-15 Life satisfaction; CRC cis rs7224685 0.501 rs781853 chr17:3953083 T/C cg09597638 chr17:3907349 NA 0.65 11.53 0.54 4.64e-26 Type 2 diabetes; CRC cis rs7666738 0.791 rs10856934 chr4:99010844 A/G cg17366294 chr4:99064904 C4orf37 -0.42 -7.21 -0.37 3.96e-12 Colonoscopy-negative controls vs population controls; CRC cis rs2282802 0.685 rs6870103 chr5:139692515 G/T cg26211634 chr5:139558579 C5orf32 -0.44 -7.47 -0.38 7.11e-13 Intelligence (multi-trait analysis); CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg21488398 chr2:70369791 NA 0.46 6.52 0.34 2.6e-10 Anxiety disorder; CRC cis rs2836974 0.899 rs114399588 chr21:40653958 G/A cg11644478 chr21:40555479 PSMG1 0.72 10.3 0.49 9.79e-22 Cognitive function; CRC cis rs9443645 0.527 rs1413969 chr6:79790982 A/G cg05283184 chr6:79620031 NA -0.45 -6.5 -0.34 2.99e-10 Intelligence (multi-trait analysis); CRC cis rs7618915 0.570 rs2336145 chr3:52629750 A/C cg18099408 chr3:52552593 STAB1 -0.45 -7.35 -0.38 1.61e-12 Bipolar disorder; CRC cis rs5753618 0.583 rs5753612 chr22:31821479 T/C cg07713946 chr22:31675144 LIMK2 0.4 6.08 0.32 3.37e-9 Colorectal cancer; CRC cis rs7772486 0.790 rs9390365 chr6:146235626 A/G cg23711669 chr6:146136114 FBXO30 -0.72 -12.79 -0.58 1.13e-30 Lobe attachment (rater-scored or self-reported); CRC cis rs1953600 0.870 rs2789695 chr10:81946840 C/T cg00277334 chr10:82204260 NA 0.37 5.91 0.31 8.4e-9 Sarcoidosis; CRC cis rs3849570 0.643 rs1969433 chr3:81968869 T/C cg07356753 chr3:81810745 GBE1 -0.47 -6.42 -0.33 4.79e-10 Waist circumference;Body mass index; CRC cis rs875971 0.798 rs57739047 chr7:65972566 A/T cg18876405 chr7:65276391 NA 0.5 8.29 0.42 2.84e-15 Aortic root size; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg22432269 chr15:22892697 CYFIP1 0.42 6.1 0.32 3.02e-9 Intelligence (multi-trait analysis); CRC cis rs6964587 1.000 rs7806184 chr7:91601978 A/G cg17063962 chr7:91808500 NA 0.81 14.19 0.62 5.71e-36 Breast cancer; CRC trans rs12702919 0.580 rs2350853 chr7:9553215 G/T cg15597424 chr4:24472487 NA -0.38 -6.06 -0.32 3.67e-9 PR interval in Tripanosoma cruzi seropositivity; CRC cis rs7044106 0.791 rs735109 chr9:123488879 C/T cg14255062 chr9:123606675 PSMD5;LOC253039 0.49 7.29 0.37 2.31e-12 Hip circumference adjusted for BMI; CRC cis rs9322193 0.884 rs2095375 chr6:150128173 C/A cg13206674 chr6:150067644 NUP43 0.57 8.14 0.41 8.29e-15 Lung cancer; CRC cis rs9311474 1.000 rs1060330 chr3:52288945 T/C cg15147215 chr3:52552868 STAB1 -0.64 -11.08 -0.52 1.88e-24 Electroencephalogram traits; CRC cis rs7542091 0.648 rs688464 chr1:209992539 C/T cg21951975 chr1:209979733 IRF6 -0.38 -6.61 -0.34 1.56e-10 Monobrow; CRC cis rs2179367 0.959 rs521845 chr6:149671698 A/C cg11245181 chr6:149772854 ZC3H12D 0.39 6.04 0.32 4.27e-9 Dupuytren's disease; CRC cis rs9914988 0.943 rs7224870 chr17:27102620 A/G cg16670446 chr17:27188758 MIR451;MIR144 0.6 10.38 0.5 5.22e-22 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs7089973 0.872 rs35622181 chr10:116631976 C/T cg23260525 chr10:116636907 FAM160B1 0.32 6.87 0.35 3.2e-11 Bipolar disorder or attention deficit hyperactivity disorder; CRC cis rs9625935 0.536 rs9608819 chr22:30260809 A/C cg01021169 chr22:30184971 ASCC2 0.38 5.8 0.3 1.55e-8 Tonsillectomy; CRC trans rs12478296 1.000 rs55777943 chr2:243040686 T/C cg18288967 chr1:45987694 PRDX1 0.65 6.92 0.36 2.34e-11 Obesity-related traits; CRC trans rs1814175 0.817 rs12290508 chr11:49621037 C/T cg15704280 chr7:45808275 SEPT13 -0.97 -18.54 -0.71 5.04e-53 Height; CRC cis rs801193 0.569 rs13226966 chr7:66233623 A/G cg18252515 chr7:66147081 NA -0.4 -5.79 -0.3 1.66e-8 Aortic root size; CRC cis rs3741151 0.686 rs2298469 chr11:73133030 T/C cg17517138 chr11:73019481 ARHGEF17 0.53 5.67 0.3 3.07e-8 GIP levels in response to oral glucose tolerance test (120 minutes); CRC trans rs2303319 0.504 rs62188988 chr2:162531068 T/C cg25193742 chr10:104614220 C10orf32 -0.71 -6.0 -0.31 5.12e-9 Cognitive function; CRC cis rs7538876 0.787 rs57142672 chr1:17744536 A/G cg07965774 chr1:17746286 RCC2 0.32 5.95 0.31 7.05e-9 Basal cell carcinoma; CRC cis rs62432291 0.681 rs429339 chr6:159660148 C/T cg14500486 chr6:159655392 FNDC1 -0.75 -10.23 -0.49 1.6e-21 Joint mobility (Beighton score); CRC cis rs887829 0.667 rs7577677 chr2:234590616 C/A cg07512295 chr2:234599026 UGT1A6;UGT1A10;UGT1A9;UGT1A7;UGT1A8 0.38 5.85 0.31 1.2e-8 Metabolic traits;Bilirubin levels;Cholelithiasis-related traits in sickle cell anemia;Metabolite levels;Total bilirubin levels in HIV-1 infection;Serum metabolite levels;Blood metabolite levels; CRC cis rs7552404 0.731 rs1770887 chr1:76401812 A/G cg10523679 chr1:76189770 ACADM -0.65 -8.24 -0.41 4.1e-15 Blood metabolite levels;Acylcarnitine levels; CRC cis rs2239547 0.521 rs9682464 chr3:52888485 C/T cg10802521 chr3:52805072 NEK4 -0.46 -6.15 -0.32 2.24e-9 Schizophrenia; CRC cis rs853679 0.882 rs4713140 chr6:28097193 C/T cg15845792 chr6:28175446 NA 0.76 6.25 0.33 1.3e-9 Depression; CRC cis rs6089584 0.606 rs6089599 chr20:60576992 A/G cg23463467 chr20:60627584 TAF4 -0.38 -7.84 -0.4 6.34e-14 Body mass index; CRC cis rs6815814 0.768 rs6851685 chr4:38893843 G/T cg06935464 chr4:38784597 TLR10 0.51 6.04 0.32 4.22e-9 Breast cancer; CRC cis rs6502050 0.777 rs7406162 chr17:80086386 C/T cg09264619 chr17:80180166 NA 0.36 6.07 0.32 3.45e-9 Life satisfaction; CRC cis rs79976124 0.879 rs10944856 chr6:66636960 G/C cg07460842 chr6:66804631 NA 0.77 9.45 0.46 6.33e-19 Type 2 diabetes; CRC cis rs17711722 0.701 rs55773927 chr7:65337902 T/C cg05627663 chr7:65219948 SNORA22;CCT6P1 0.5 7.48 0.38 6.79e-13 Calcium levels; CRC cis rs1865760 1.000 rs7757666 chr6:25902626 T/C cg17691542 chr6:26056736 HIST1H1C 0.56 8.39 0.42 1.45e-15 Height; CRC cis rs3736485 0.966 rs7177720 chr15:51890282 T/C cg08986416 chr15:51914746 DMXL2 -0.45 -6.43 -0.33 4.59e-10 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs787274 0.718 rs10739379 chr9:115640976 C/G cg13803584 chr9:115635662 SNX30 -0.66 -6.1 -0.32 2.95e-9 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs2019137 0.560 rs11123172 chr2:113984303 C/T cg21610815 chr2:113994035 PAX8;LOC654433;LOC440839 -0.57 -8.66 -0.43 2.18e-16 Lymphocyte counts; CRC cis rs2839186 0.709 rs2839176 chr21:47678173 A/G cg13126279 chr21:47581558 C21orf56 -0.48 -7.42 -0.38 9.97e-13 Testicular germ cell tumor; CRC cis rs10504073 0.669 rs818558 chr8:50030855 A/G cg00325661 chr8:49890786 NA 0.46 8.21 0.41 5.01e-15 Blood metabolite ratios; CRC cis rs2933343 0.903 rs2638846 chr3:128587163 A/T cg11901034 chr3:128598214 ACAD9 -0.5 -6.12 -0.32 2.64e-9 IgG glycosylation; CRC cis rs17095355 1.000 rs975442 chr10:111705895 A/G cg00817464 chr10:111662876 XPNPEP1 -0.6 -7.77 -0.39 1.02e-13 Biliary atresia; CRC cis rs1008375 1.000 rs4642241 chr4:17617111 T/C cg16339924 chr4:17578868 LAP3 0.58 7.9 0.4 4.16e-14 Parasitemia in Tripanosoma cruzi seropositivity; CRC trans rs6703335 0.870 rs10803142 chr1:243598234 A/G cg00628130 chr8:95908808 CCNE2 0.46 6.62 0.34 1.42e-10 Schizophrenia;Schizophrenia, schizoaffective disorder or bipolar disorder; CRC trans rs1997103 1.000 rs6593238 chr7:55411048 A/G cg20935933 chr6:143382018 AIG1 0.51 6.65 0.34 1.25e-10 QRS interval (sulfonylurea treatment interaction); CRC cis rs6496667 0.821 rs77731392 chr15:90897450 G/C cg04176472 chr15:90893244 GABARAPL3 0.6 8.04 0.41 1.69e-14 Rheumatoid arthritis; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg20731533 chr19:36631058 CAPNS1 0.43 6.33 0.33 7.81e-10 Response to antipsychotic treatment; CRC cis rs875971 0.862 rs6971059 chr7:66067032 A/G cg00343986 chr7:65444356 GUSB -0.45 -6.17 -0.32 1.96e-9 Aortic root size; CRC cis rs7917772 0.636 rs2250580 chr10:104505687 C/G cg22532475 chr10:104410764 TRIM8 -0.39 -6.42 -0.33 4.9e-10 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC trans rs561341 0.941 rs8066156 chr17:30361629 A/G cg27661571 chr11:113659931 NA -0.68 -8.76 -0.43 1.07e-16 Hip circumference adjusted for BMI; CRC cis rs9443645 0.838 rs946022 chr6:79672133 G/T cg11833968 chr6:79620685 NA -0.36 -6.18 -0.32 1.9e-9 Intelligence (multi-trait analysis); CRC cis rs7615952 0.688 rs12638224 chr3:125541320 C/T cg05084668 chr3:125655381 ALG1L -0.42 -5.85 -0.31 1.17e-8 Blood pressure (smoking interaction); CRC cis rs2380220 1.000 rs2380222 chr6:95975395 C/T cg04719120 chr6:96025338 MANEA 0.61 6.99 0.36 1.58e-11 Behavioural disinhibition (generation interaction); CRC cis rs5750830 0.649 rs5750822 chr22:39826788 C/T cg25956985 chr22:39795188 MAP3K7IP1 -0.45 -6.66 -0.34 1.13e-10 Intelligence (multi-trait analysis); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg07172597 chr19:42817659 TMEM145 0.52 7.29 0.37 2.29e-12 Response to antipsychotic treatment; CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg04364726 chr19:21512166 ZNF708 0.38 6.2 0.32 1.66e-9 Obesity-related traits; CRC cis rs12900463 0.813 rs187316 chr15:85405995 T/C cg11189052 chr15:85197271 WDR73 0.45 6.07 0.32 3.44e-9 Adverse response to chemotherapy (neutropenia/leucopenia) (gemcitabine); CRC cis rs7188873 1 rs7188873 chr16:24727064 A/G cg06028605 chr16:24865363 SLC5A11 -0.35 -6.56 -0.34 2.11e-10 Intelligence (multi-trait analysis); CRC cis rs875971 1.000 rs1167612 chr7:65567976 C/A cg18876405 chr7:65276391 NA -0.52 -9.08 -0.45 1.02e-17 Aortic root size; CRC cis rs9368481 0.761 rs9348746 chr6:26970357 C/G cg12292205 chr6:26970375 C6orf41 -0.75 -12.3 -0.56 7.55e-29 Autism spectrum disorder or schizophrenia; CRC cis rs9486719 1.000 rs3906199 chr6:97049899 C/A cg18709589 chr6:96969512 KIAA0776 -0.51 -5.85 -0.31 1.21e-8 Migraine;Coronary artery disease; CRC cis rs875971 0.660 rs28698552 chr7:66005018 A/G cg25985355 chr7:65971099 NA -0.32 -5.67 -0.3 3.12e-8 Aortic root size; CRC cis rs501916 0.605 rs17332642 chr15:48080805 G/A cg16110827 chr15:48056943 SEMA6D -0.5 -7.54 -0.38 4.6e-13 Inflammatory bowel disease;Ulcerative colitis; CRC cis rs4474465 0.850 rs7112872 chr11:78227396 C/A cg27205649 chr11:78285834 NARS2 0.49 6.12 0.32 2.61e-9 Alzheimer's disease (survival time); CRC cis rs765787 0.530 rs11070444 chr15:45513121 T/C cg24006582 chr15:45444508 DUOX1 0.52 7.54 0.38 4.61e-13 Uric acid levels; CRC cis rs6754311 0.681 rs4954493 chr2:136609975 T/C cg25344623 chr2:136566232 LCT 0.33 6.06 0.32 3.8e-9 Mosquito bite size; CRC cis rs12681287 0.604 rs6471316 chr8:87403587 G/C cg27223183 chr8:87520930 FAM82B 0.53 7.2 0.37 4.05e-12 Caudate activity during reward; CRC cis rs11628318 0.614 rs12590775 chr14:103150623 A/G cg12046867 chr14:103022105 NA 0.42 6.26 0.33 1.23e-9 Platelet count; CRC cis rs9733 0.527 rs11204694 chr1:150653391 G/A cg15448220 chr1:150897856 SETDB1 0.49 7.03 0.36 1.2e-11 Tonsillectomy; CRC cis rs12681287 0.604 rs7017716 chr8:87429001 A/C cg27223183 chr8:87520930 FAM82B -0.48 -7.16 -0.37 5.42e-12 Caudate activity during reward; CRC trans rs9858542 0.953 rs9853683 chr3:49512588 A/G cg21582582 chr3:182698605 DCUN1D1 -0.51 -6.47 -0.34 3.47e-10 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs10870270 0.956 rs7915388 chr10:133734972 G/A cg08754478 chr10:133766260 PPP2R2D -0.65 -9.43 -0.46 7.78e-19 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; CRC cis rs9534288 0.731 rs7981685 chr13:46605495 G/A cg15192986 chr13:46630673 CPB2 -0.67 -9.79 -0.47 5.04e-20 Blood protein levels; CRC cis rs4808199 0.947 rs4808960 chr19:19574277 G/C cg03709012 chr19:19516395 GATAD2A 1.0 11.99 0.55 1.01e-27 Nonalcoholic fatty liver disease; CRC cis rs2816062 0.735 rs2816045 chr1:18892999 A/G cg18795169 chr1:18902165 NA -0.91 -18.72 -0.72 9.45e-54 Urate levels in lean individuals; CRC cis rs6860806 0.507 rs272878 chr5:131671769 C/T cg18301423 chr5:131593218 PDLIM4 -0.39 -6.61 -0.34 1.51e-10 Breast cancer; CRC trans rs7615952 0.546 rs4428131 chr3:125346479 C/T cg16558177 chr4:4109446 NA -0.56 -6.48 -0.34 3.35e-10 Blood pressure (smoking interaction); CRC cis rs13191362 1.000 rs73008453 chr6:163013384 G/A cg21926612 chr6:163149169 PACRG;PARK2 0.78 10.8 0.51 1.77e-23 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs7618915 0.547 rs62253733 chr3:52653414 A/G cg08222913 chr3:52553049 STAB1 -0.34 -6.08 -0.32 3.35e-9 Bipolar disorder; CRC cis rs561341 1.000 rs521919 chr17:30298039 G/T cg23018236 chr17:30244563 NA -0.58 -7.85 -0.4 6.09e-14 Hip circumference adjusted for BMI; CRC cis rs2841277 0.708 rs10083496 chr14:105402786 G/A cg15352829 chr14:105391018 PLD4 -0.49 -10.83 -0.51 1.41e-23 Rheumatoid arthritis; CRC cis rs75920871 0.588 rs10892054 chr11:116868221 C/T cg20608306 chr11:116969690 SIK3 -0.32 -5.94 -0.31 7.18e-9 Subjective well-being; CRC cis rs3824347 0.839 rs10869471 chr9:77629472 C/A cg01251476 chr9:77566080 C9orf40 0.36 5.63 0.3 3.8e-8 Urinary magnesium-to-creatinine ratio; CRC cis rs2882667 0.659 rs700621 chr5:138098430 C/T cg09476006 chr5:138032270 NA -0.59 -10.52 -0.5 1.7e-22 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs875971 0.545 rs11767262 chr7:65767224 T/A cg11764359 chr7:65958608 NA 0.47 6.01 0.31 4.95e-9 Aortic root size; CRC cis rs1943345 0.556 rs553484 chr11:82921538 C/T cg07047830 chr11:82868014 PCF11 0.46 6.44 0.33 4.24e-10 Obesity-related traits; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg05902997 chr5:65440515 SFRS12 0.41 6.49 0.34 3.17e-10 Liver disease severity in Alagille syndrome; CRC cis rs951366 0.528 rs1172198 chr1:205662718 C/T cg23034840 chr1:205782522 SLC41A1 0.45 5.91 0.31 8.75e-9 Menarche (age at onset); CRC cis rs2404602 1.000 rs1117367 chr15:76872330 A/C cg03037974 chr15:76606532 NA 0.57 9.55 0.47 3.07e-19 Blood metabolite levels; CRC cis rs317689 0.718 rs315122 chr12:69771073 G/T cg20891283 chr12:69753455 YEATS4 0.66 8.51 0.42 6.16e-16 Response to diuretic therapy; CRC cis rs7618915 0.501 rs2109634 chr3:52752075 T/G cg11645453 chr3:52864694 ITIH4 0.37 6.53 0.34 2.57e-10 Bipolar disorder; CRC cis rs13392177 0.684 rs11682371 chr2:219079513 G/A cg04880052 chr2:219191631 PNKD -0.39 -5.93 -0.31 7.68e-9 Pyoderma gangrenosum in inflammatory bowel disease; CRC cis rs67311347 0.524 rs7649168 chr3:40356158 T/C cg09455208 chr3:40491958 NA 0.31 6.06 0.32 3.74e-9 Renal cell carcinoma; CRC cis rs1957429 0.901 rs1467570 chr14:65347858 A/G cg23373153 chr14:65346875 NA 0.79 8.25 0.41 3.9e-15 Pediatric areal bone mineral density (radius); CRC cis rs7666738 0.791 rs10022061 chr4:98926821 T/C cg05340658 chr4:99064831 C4orf37 0.6 9.35 0.46 1.41e-18 Colonoscopy-negative controls vs population controls; CRC cis rs4964805 0.580 rs10861097 chr12:104170474 C/T cg02344784 chr12:104178138 NT5DC3 0.45 6.86 0.35 3.4e-11 Attention deficit hyperactivity disorder; CRC cis rs7769051 0.522 rs7762248 chr6:133105303 A/C cg07930552 chr6:133119739 C6orf192 0.63 5.6 0.3 4.48e-8 Type 2 diabetes nephropathy; CRC cis rs2257205 0.667 rs6503872 chr17:56696008 C/T cg25885038 chr17:56607967 SEPT4 -0.53 -5.79 -0.3 1.62e-8 Pancreatic cancer; CRC cis rs13191362 1.000 rs13204013 chr6:163002480 T/A cg23758597 chr6:163146217 PARK2 -0.55 -6.12 -0.32 2.61e-9 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs7618501 0.699 rs1317154 chr3:49910084 T/C cg05623727 chr3:50126028 RBM5 0.44 7.07 0.36 9.24e-12 Intelligence (multi-trait analysis); CRC trans rs6600671 0.967 rs11249347 chr1:121188347 G/T cg09829573 chr1:144692074 NBPF9 -0.4 -5.99 -0.31 5.47e-9 Hip geometry; CRC cis rs62244186 0.711 rs6778410 chr3:44743993 C/T cg10263370 chr3:44754102 ZNF502 -0.41 -6.81 -0.35 4.57e-11 Depressive symptoms; CRC trans rs9650657 0.615 rs1549796 chr8:10692359 C/T cg06636001 chr8:8085503 FLJ10661 -0.41 -6.17 -0.32 2.04e-9 Neuroticism; CRC cis rs7618501 1.000 rs35261599 chr3:49773236 G/A cg24308560 chr3:49941425 MST1R 0.46 7.23 0.37 3.51e-12 Intelligence (multi-trait analysis); CRC cis rs834811 0.602 rs7784422 chr7:135883502 G/T cg01726295 chr7:135938950 NA 0.35 5.95 0.31 7.01e-9 Post-traumatic stress disorder; CRC trans rs6686842 1.000 rs6663565 chr1:41563688 C/T cg19787969 chr8:9763211 NA 0.28 5.97 0.31 6.25e-9 Height; CRC cis rs9467160 1.000 rs9467162 chr6:24442047 T/C cg20631270 chr6:24437470 GPLD1 0.48 6.34 0.33 7.61e-10 Liver enzyme levels; CRC cis rs9399135 1.000 rs11754265 chr6:135356216 C/G cg22676075 chr6:135203613 NA 0.4 6.15 0.32 2.31e-9 Red blood cell count; CRC cis rs9847710 0.901 rs2564937 chr3:53025859 C/T cg04503182 chr3:53078218 SFMBT1 0.41 6.19 0.32 1.75e-9 Ulcerative colitis; CRC cis rs3849570 0.555 rs6548783 chr3:81993621 G/A cg07356753 chr3:81810745 GBE1 -0.51 -7.11 -0.37 7.08e-12 Waist circumference;Body mass index; CRC cis rs13118159 0.550 rs13123016 chr4:1340889 T/C cg20887711 chr4:1340912 KIAA1530 0.75 10.48 0.5 2.38e-22 Longevity; CRC cis rs60843830 1.000 rs17713729 chr2:249092 A/C cg00108164 chr2:264199 ACP1;SH3YL1 0.62 10.12 0.49 4.01e-21 Spherical equivalent (joint analysis main effects and education interaction); CRC cis rs9325144 0.650 rs6582631 chr12:38744135 T/C cg26384229 chr12:38710491 ALG10B 0.54 8.06 0.41 1.44e-14 Morning vs. evening chronotype; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg17358899 chr7:148580458 EZH2 0.46 6.7 0.35 9.26e-11 Response to antipsychotic treatment; CRC cis rs7584330 0.910 rs6713555 chr2:238398182 A/G cg16989719 chr2:238392110 NA 0.41 7.45 0.38 8.26e-13 Prostate cancer; CRC cis rs672059 1.000 rs551569 chr1:183158293 G/C ch.1.3577855R chr1:183094577 LAMC1 0.5 7.28 0.37 2.41e-12 Hypertriglyceridemia; CRC cis rs9648716 1.000 rs6966197 chr7:140597229 C/A cg10747023 chr7:140774559 NA 0.45 5.9 0.31 9.21e-9 Type 2 diabetes; CRC cis rs10256972 0.567 rs2949185 chr7:1209013 A/G cg18402987 chr7:1209562 NA 0.57 8.63 0.43 2.63e-16 Longevity;Endometriosis; CRC cis rs1983891 1.000 rs4714485 chr6:41536587 T/G cg20194872 chr6:41519635 FOXP4 0.39 5.64 0.3 3.61e-8 Prostate cancer; CRC cis rs892961 0.932 rs67719929 chr17:75412605 G/A cg05865280 chr17:75406074 SEPT9 0.63 14.51 0.62 3.27e-37 Airflow obstruction; CRC cis rs10896135 0.526 rs1987169 chr11:66448044 A/G cg24851651 chr11:66362959 CCS -0.49 -8.12 -0.41 9.31e-15 Bipolar disorder; CRC cis rs11997175 0.624 rs17778980 chr8:33700926 T/C cg04338863 chr8:33670619 NA 0.43 6.76 0.35 6.28e-11 Body mass index; CRC cis rs4148883 0.689 rs1869458 chr4:100024728 C/G cg13256891 chr4:100009986 ADH5 0.46 6.55 0.34 2.27e-10 Alcohol dependence; CRC cis rs780096 0.526 rs1647276 chr2:27688601 C/T cg12000995 chr2:27665139 KRTCAP3 -0.32 -6.67 -0.35 1.1e-10 Total body bone mineral density; CRC cis rs736408 0.609 rs2336545 chr3:52787603 C/T cg11645453 chr3:52864694 ITIH4 -0.34 -5.92 -0.31 7.88e-9 Bipolar disorder; CRC cis rs2153535 0.580 rs6941670 chr6:8446346 G/A cg07606381 chr6:8435919 SLC35B3 0.67 10.86 0.51 1.13e-23 Motion sickness; CRC cis rs17376456 1.000 rs35184505 chr5:93561535 A/G cg21475434 chr5:93447410 FAM172A 0.77 6.87 0.35 3.14e-11 Diabetic retinopathy; CRC cis rs731174 0.759 rs12133523 chr1:38153110 T/A cg06917450 chr1:38156652 C1orf109 -0.51 -7.18 -0.37 4.74e-12 Prostate cancer (SNP x SNP interaction); CRC cis rs8017423 0.605 rs4904676 chr14:90819220 G/A cg14092571 chr14:90743983 NA 0.39 5.94 0.31 7.29e-9 Mortality in heart failure; CRC cis rs7129556 0.906 rs72945508 chr11:77267537 G/C cg12586386 chr11:77299805 AQP11 0.41 5.67 0.3 3.16e-8 Weight loss (gastric bypass surgery); CRC cis rs2985684 1.000 rs2985697 chr14:50092902 A/G cg04989706 chr14:50066350 PPIL5 -0.54 -7.88 -0.4 4.75e-14 Carotid intima media thickness; CRC cis rs35883536 0.566 rs12566440 chr1:101095202 A/G cg14515779 chr1:101123966 NA -0.35 -6.26 -0.33 1.19e-9 Monocyte count; CRC cis rs6502050 0.799 rs7501461 chr17:80109806 C/T cg13198984 chr17:80129470 CCDC57 0.46 8.16 0.41 6.94e-15 Life satisfaction; CRC cis rs473651 0.935 rs472357 chr2:239355454 A/G cg21699342 chr2:239360505 ASB1 -0.57 -10.21 -0.49 1.98e-21 Multiple system atrophy; CRC cis rs10140922 0.966 rs10083375 chr14:35823531 C/T cg07166546 chr14:35805898 NA -0.3 -6.0 -0.31 5.31e-9 Hip circumference adjusted for BMI; CRC cis rs10504229 0.906 rs56138544 chr8:58184558 A/C cg02290350 chr8:58132656 NA -0.42 -5.96 -0.31 6.62e-9 Developmental language disorder (linguistic errors); CRC cis rs950169 0.840 rs72748702 chr15:84915246 A/G cg11189052 chr15:85197271 WDR73 0.64 8.98 0.44 2.1e-17 Schizophrenia; CRC cis rs9308731 0.644 rs7602904 chr2:111880600 C/T cg18646521 chr2:111875858 NA 0.37 5.78 0.3 1.78e-8 Chronic lymphocytic leukemia; CRC cis rs11167764 1.000 rs6580220 chr5:141480558 G/A cg08523384 chr5:141488047 NDFIP1 -0.52 -8.46 -0.42 9.13e-16 Crohn's disease; CRC cis rs4713118 0.516 rs4713142 chr6:28106347 T/G cg21251018 chr6:28226885 NKAPL 0.48 6.33 0.33 7.86e-10 Parkinson's disease; CRC cis rs8180040 1.000 rs11714294 chr3:47339723 G/A cg10298567 chr3:47292165 KIF9 0.45 7.18 0.37 4.55e-12 Colorectal cancer; CRC cis rs422249 0.896 rs174449 chr11:61640379 A/G cg01500311 chr11:61656094 FADS3 -0.43 -7.53 -0.38 4.99e-13 Trans fatty acid levels; CRC cis rs6120849 0.663 rs11698868 chr20:33549946 C/T cg24642439 chr20:33292090 TP53INP2 0.46 6.08 0.32 3.36e-9 Protein C levels; CRC cis rs7412746 0.621 rs7518156 chr1:150945794 A/C cg15448220 chr1:150897856 SETDB1 0.48 6.94 0.36 2.16e-11 Melanoma; CRC cis rs10426930 0.607 rs858415 chr19:5055996 C/T cg15621731 chr19:5074616 KDM4B 0.31 5.96 0.31 6.54e-9 Monocyte percentage of white cells; CRC cis rs796364 1.000 rs1658807 chr2:200767512 C/T cg23649088 chr2:200775458 C2orf69 0.56 6.09 0.32 3.18e-9 Schizophrenia; CRC cis rs10883723 0.810 rs1409311 chr10:104282160 G/A cg11453585 chr10:104263688 ACTR1A;SUFU 0.9 16.72 0.68 7.3e-46 Allergic disease (asthma, hay fever or eczema); CRC cis rs2223471 1.000 rs2223471 chr6:50733648 A/T cg03432817 chr6:50765336 NA 0.38 6.18 0.32 1.89e-9 Subcutaneous adipose tissue; CRC cis rs10883723 0.810 rs3818470 chr10:104263675 T/C cg22532475 chr10:104410764 TRIM8 -0.37 -6.86 -0.35 3.51e-11 Allergic disease (asthma, hay fever or eczema); CRC cis rs1692580 0.870 rs590367 chr1:2162944 C/T cg21194808 chr1:2205498 SKI 0.43 6.23 0.33 1.4e-9 Coronary artery disease; CRC cis rs3796352 1.000 rs11713290 chr3:52971579 G/A cg27565382 chr3:53032988 SFMBT1 0.7 6.16 0.32 2.07e-9 Immune reponse to smallpox (secreted IL-2); CRC cis rs10504229 0.593 rs76922080 chr8:57985837 C/G cg22535103 chr8:58192502 C8orf71 -0.63 -6.58 -0.34 1.85e-10 Developmental language disorder (linguistic errors); CRC cis rs9420 0.961 rs11605731 chr11:57524089 C/G cg23127183 chr11:57508653 C11orf31 -0.53 -7.08 -0.36 8.9e-12 Schizophrenia; CRC cis rs5750830 0.649 rs5750808 chr22:39790987 G/A cg24399712 chr22:39784796 NA -0.49 -9.49 -0.46 4.8e-19 Intelligence (multi-trait analysis); CRC cis rs826838 0.967 rs2069211 chr12:39128892 C/T cg13010199 chr12:38710504 ALG10B -0.41 -5.84 -0.31 1.27e-8 Heart rate; CRC cis rs11628318 0.713 rs4900543 chr14:103029024 T/C cg02094049 chr14:103021097 NA -0.54 -6.97 -0.36 1.7e-11 Platelet count; CRC cis rs6545883 0.630 rs12998475 chr2:61437487 T/C cg15711740 chr2:61764176 XPO1 0.41 5.62 0.3 4.01e-8 Tuberculosis; CRC cis rs1448094 0.967 rs7974794 chr12:86323280 A/G cg19622623 chr12:86230825 RASSF9 -0.35 -5.69 -0.3 2.8e-8 Major depressive disorder; CRC cis rs6840360 0.967 rs6535815 chr4:152609700 A/C cg09659197 chr4:152720779 NA 0.5 10.71 0.51 3.59e-23 Intelligence (multi-trait analysis); CRC cis rs11971779 0.680 rs6962637 chr7:139051350 G/A cg23387468 chr7:139079360 LUC7L2 0.41 7.04 0.36 1.14e-11 Diisocyanate-induced asthma; CRC cis rs6540559 0.673 rs11803382 chr1:209986426 G/A cg21951975 chr1:209979733 IRF6 0.48 6.46 0.34 3.87e-10 Cleft lip with or without cleft palate; CRC trans rs4745661 0.703 rs1328530 chr9:80409138 C/G cg02160872 chr5:212506 CCDC127 0.37 6.1 0.32 3.06e-9 IgG glycosylation; CRC cis rs60871478 1.000 rs62432899 chr7:826542 G/C cg05535760 chr7:792225 HEATR2 1.03 13.47 0.6 2.98e-33 Cerebrospinal P-tau181p levels; CRC cis rs6912958 0.559 rs107689 chr6:88069333 G/T cg08069147 chr6:88032118 GJB7;C6orf162 0.67 10.93 0.52 6.15e-24 Monocyte percentage of white cells; CRC cis rs3008870 0.583 rs2147838 chr1:67399466 T/C cg11518657 chr1:67396239 MIER1 0.55 5.93 0.31 7.58e-9 Lymphocyte percentage of white cells; CRC cis rs10791323 0.628 rs2853117 chr11:133705266 T/G cg06766960 chr11:133703094 NA -0.36 -6.1 -0.32 2.92e-9 Childhood ear infection; CRC trans rs7618501 0.633 rs7628058 chr3:50039474 C/T cg21659725 chr3:3221576 CRBN 0.61 9.81 0.48 4.35e-20 Intelligence (multi-trait analysis); CRC cis rs2257205 0.667 rs9909635 chr17:56752159 G/A cg25885038 chr17:56607967 SEPT4 -0.52 -5.69 -0.3 2.87e-8 Pancreatic cancer; CRC cis rs9527 0.590 rs10883839 chr10:104920341 A/G cg15744005 chr10:104629667 AS3MT -0.3 -5.95 -0.31 6.94e-9 Arsenic metabolism; CRC cis rs11785693 0.862 rs17435605 chr8:4987302 A/G cg26367366 chr8:4980734 NA 0.81 9.96 0.48 1.31e-20 Neuroticism (multi-trait analysis);Neuroticism; CRC cis rs4713118 0.513 rs149959 chr6:28013854 T/C cg23161317 chr6:28129485 ZNF389 0.45 6.39 0.33 5.77e-10 Parkinson's disease; CRC cis rs7589728 0.563 rs12479338 chr2:88444513 C/T cg04511125 chr2:88470314 THNSL2 0.82 8.7 0.43 1.59e-16 Plasma clusterin levels; CRC cis rs35123781 0.654 rs356486 chr5:139085103 C/G cg10513866 chr5:139070639 NA -0.53 -7.96 -0.4 2.82e-14 Schizophrenia; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg13788301 chr22:35695944 TOM1 0.42 6.22 0.32 1.55e-9 Intelligence (multi-trait analysis); CRC cis rs9611565 0.694 rs202639 chr22:41856137 T/A cg06634786 chr22:41940651 POLR3H 0.66 7.79 0.39 8.63e-14 Vitiligo; CRC cis rs3760982 0.813 rs8111664 chr19:44295092 G/A cg11993925 chr19:44307056 LYPD5 -0.47 -7.68 -0.39 1.86e-13 Breast cancer (estrogen-receptor negative);Breast cancer; CRC cis rs6445525 1.000 rs9860098 chr3:65992808 A/G cg06109867 chr3:66002991 MAGI1 -0.39 -6.46 -0.34 3.85e-10 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs1005277 0.579 rs1780138 chr10:38501654 A/G cg25517755 chr10:38738941 LOC399744 -0.4 -5.91 -0.31 8.75e-9 Extrinsic epigenetic age acceleration; CRC cis rs10540 1.000 rs71487296 chr11:500282 G/A cg03352830 chr11:487213 PTDSS2 0.65 7.42 0.38 1.02e-12 Body mass index; CRC cis rs4319547 0.915 rs7316734 chr12:123117425 A/G cg05707623 chr12:122985044 ZCCHC8 -0.69 -8.57 -0.43 4.03e-16 Body mass index; CRC cis rs4563143 0.647 rs34218744 chr19:29256821 A/T cg12756686 chr19:29218302 NA 0.6 8.96 0.44 2.38e-17 Methadone dose in opioid dependence; CRC cis rs60843830 0.661 rs7561648 chr2:105171 G/T cg25945732 chr2:264204 ACP1;SH3YL1 0.46 6.39 0.33 5.56e-10 Spherical equivalent (joint analysis main effects and education interaction); CRC trans rs853679 0.760 rs9295768 chr6:28209102 G/A cg06606381 chr12:133084897 FBRSL1 -0.65 -6.7 -0.35 8.99e-11 Depression; CRC cis rs11122272 0.766 rs2808608 chr1:231543175 A/G cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.63 -9.76 -0.47 6.15e-20 Hemoglobin concentration; CRC cis rs2573652 0.722 rs12595247 chr15:100541689 C/T cg00587665 chr15:100533223 ADAMTS17 -0.37 -6.51 -0.34 2.86e-10 Height; CRC cis rs9435341 0.965 rs1762485 chr1:107625056 C/T cg15468180 chr1:107600409 PRMT6 -0.41 -6.07 -0.32 3.51e-9 Facial morphology (factor 21, depth of nasal alae); CRC cis rs12410462 0.579 rs115037090 chr1:227666191 A/G cg23173402 chr1:227635558 NA 0.87 8.85 0.44 5.4e-17 Major depressive disorder; CRC cis rs2730260 0.537 rs3793223 chr7:158863574 C/A cg02254261 chr7:158964346 NA -0.51 -5.98 -0.31 5.87e-9 Myopia (pathological); CRC cis rs9467711 0.606 rs9379900 chr6:26603811 A/C cg16898833 chr6:26189333 HIST1H4D 0.94 7.7 0.39 1.64e-13 Autism spectrum disorder or schizophrenia; CRC cis rs1552244 0.744 rs6763366 chr3:10033544 T/C cg13047869 chr3:10149882 C3orf24 0.51 6.97 0.36 1.74e-11 Alzheimer's disease; CRC trans rs2303319 0.504 rs56100249 chr2:162415157 T/C cg17456266 chr11:43964085 LOC387763 -0.55 -5.98 -0.31 5.95e-9 Cognitive function; CRC cis rs9322193 0.923 rs9480031 chr6:150080011 A/C cg07701084 chr6:150067640 NUP43 0.59 8.71 0.43 1.48e-16 Lung cancer; CRC cis rs801193 0.569 rs13226966 chr7:66233623 A/G cg18876405 chr7:65276391 NA 0.5 8.14 0.41 8.53e-15 Aortic root size; CRC cis rs7666738 0.830 rs6830124 chr4:99054872 C/T cg17366294 chr4:99064904 C4orf37 -0.45 -7.7 -0.39 1.64e-13 Colonoscopy-negative controls vs population controls; CRC cis rs34172651 0.917 rs2059134 chr16:24816492 C/T cg00339695 chr16:24857497 SLC5A11 -0.31 -7.23 -0.37 3.41e-12 Intelligence (multi-trait analysis); CRC cis rs9381040 0.610 rs6940356 chr6:41020360 C/T cg09580153 chr6:41068724 NFYA;LOC221442 -0.42 -6.14 -0.32 2.42e-9 Alzheimer's disease (late onset); CRC cis rs1552244 0.554 rs2272121 chr3:10047680 A/G cg16606324 chr3:10149918 C3orf24 0.48 7.03 0.36 1.23e-11 Alzheimer's disease; CRC cis rs2235649 0.588 rs11863172 chr16:1909083 C/G cg00935504 chr16:1863053 HAGH 0.38 5.99 0.31 5.57e-9 Blood metabolite levels; CRC cis rs12599426 0.852 rs3853178 chr16:34597543 C/T cg08331635 chr16:34430078 NA -0.47 -5.76 -0.3 1.94e-8 Palmitoleic acid (16:1n-7) levels; CRC cis rs7618501 0.602 rs2526743 chr3:50115245 G/A cg24308560 chr3:49941425 MST1R 0.5 8.23 0.41 4.39e-15 Intelligence (multi-trait analysis); CRC cis rs1348850 0.651 rs4893931 chr2:178228212 T/C cg22681709 chr2:178499509 PDE11A -0.31 -5.62 -0.3 4.15e-8 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs6912958 0.781 rs2325064 chr6:88224467 G/A cg08069147 chr6:88032118 GJB7;C6orf162 -0.55 -8.26 -0.41 3.58e-15 Monocyte percentage of white cells; CRC cis rs9648716 0.808 rs6953658 chr7:140467095 T/C cg10747023 chr7:140774559 NA 0.44 5.64 0.3 3.71e-8 Type 2 diabetes; CRC cis rs7517126 1.000 rs2336504 chr1:196843654 C/T cg13682187 chr1:196946512 CFHR5 -0.38 -6.16 -0.32 2.09e-9 Blood protein levels; CRC cis rs208520 0.674 rs207103 chr6:66795568 G/T cg07460842 chr6:66804631 NA -1.09 -15.38 -0.65 1.37e-40 Exhaled nitric oxide output; CRC cis rs208520 1.000 rs72884025 chr6:66994185 T/C cg07460842 chr6:66804631 NA 0.92 11.19 0.53 7.51e-25 Exhaled nitric oxide output; CRC cis rs733592 0.560 rs61918773 chr12:48421774 G/A cg24011408 chr12:48396354 COL2A1 -0.45 -6.64 -0.34 1.3e-10 Plateletcrit; CRC cis rs7666738 0.716 rs7656233 chr4:99079237 G/A cg05340658 chr4:99064831 C4orf37 0.51 7.61 0.39 2.83e-13 Colonoscopy-negative controls vs population controls; CRC cis rs736408 0.570 rs11130327 chr3:52793239 A/G cg10802521 chr3:52805072 NEK4 -0.6 -9.02 -0.45 1.61e-17 Bipolar disorder; CRC cis rs7493 0.950 rs6961624 chr7:95037661 T/C cg04155289 chr7:94953770 PON1 -0.59 -7.53 -0.38 5.06e-13 Yu-Zhi constitution type in type 2 diabetes; CRC trans rs9929218 1.000 rs4500718 chr16:68754312 A/G cg04657470 chr2:198365150 HSPE1;HSPD1 -0.97 -14.11 -0.61 1.1e-35 Colorectal cancer; CRC cis rs7149337 0.752 rs8021773 chr14:51691528 C/T cg18282456 chr14:51561492 TRIM9 0.3 5.71 0.3 2.5e-8 Cancer; CRC cis rs9443189 0.570 rs567903 chr6:76327851 C/T cg01950844 chr6:76311363 SENP6 0.74 9.74 0.47 7.13e-20 Prostate cancer; CRC cis rs1153858 0.725 rs74572151 chr15:45647526 T/G cg21132104 chr15:45694354 SPATA5L1 0.57 8.43 0.42 1.1e-15 Homoarginine levels; CRC cis rs3087591 0.960 rs12940303 chr17:29604862 C/T cg24425628 chr17:29625626 OMG;NF1 0.88 16.85 0.68 2.35e-46 Hip circumference; CRC cis rs875971 0.545 rs73376394 chr7:65637681 C/T cg11764359 chr7:65958608 NA 0.43 5.62 0.3 4e-8 Aortic root size; CRC cis rs4975709 0.569 rs1684965 chr5:1865248 A/G cg15595755 chr5:1867978 NA 0.43 7.32 0.37 1.89e-12 Cardiovascular disease risk factors; CRC cis rs6604026 0.656 rs11164843 chr1:93416142 A/C cg17283838 chr1:93427260 FAM69A 0.42 5.65 0.3 3.43e-8 Multiple sclerosis; CRC cis rs7216064 1.000 rs4790908 chr17:65852907 T/G cg12091567 chr17:66097778 LOC651250 -0.64 -7.97 -0.4 2.6e-14 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CRC cis rs6570726 0.764 rs1912023 chr6:145824278 C/A cg13319975 chr6:146136371 FBXO30 -0.44 -6.66 -0.34 1.13e-10 Lobe attachment (rater-scored or self-reported); CRC cis rs853679 0.517 rs9295759 chr6:28124469 C/T cg02683197 chr6:28174875 NA 0.87 10.73 0.51 3.25e-23 Depression; CRC cis rs1401999 1.000 rs1401999 chr3:183678342 C/G cg01324343 chr3:183735012 ABCC5 0.81 14.74 0.63 4.18e-38 Anterior chamber depth; CRC cis rs736408 0.609 rs1029871 chr3:52797634 G/C cg10802521 chr3:52805072 NEK4 -0.57 -8.66 -0.43 2.17e-16 Bipolar disorder; CRC cis rs1153858 1.000 rs7171577 chr15:45627979 G/A cg14582100 chr15:45693742 SPATA5L1 0.28 5.82 0.31 1.43e-8 Homoarginine levels; CRC cis rs9314323 0.729 rs7823021 chr8:26224958 G/T cg13160058 chr8:26243215 BNIP3L -0.49 -8.17 -0.41 6.84e-15 Red cell distribution width; CRC trans rs4650994 0.544 rs2476560 chr1:178594919 A/G cg05059571 chr16:84539110 KIAA1609 0.58 7.87 0.4 5.02e-14 HDL cholesterol levels;HDL cholesterol; CRC cis rs2075371 0.933 rs2244548 chr7:133986234 A/G cg02659138 chr7:134003124 SLC35B4 0.37 6.41 0.33 5.15e-10 Mean platelet volume; CRC cis rs3785574 0.962 rs2955235 chr17:61966950 A/C cg23090583 chr17:61904693 PSMC5;FTSJ3 0.57 8.05 0.41 1.55e-14 Height; CRC cis rs3785888 0.548 rs197922 chr17:45008570 G/A cg16759221 chr17:45003025 GOSR2 -0.63 -9.54 -0.47 3.23e-19 Cleft lip with or without cleft palate; CRC cis rs4819052 0.788 rs4819051 chr21:46693128 C/T cg02159808 chr21:46707872 POFUT2;LOC642852 0.51 6.71 0.35 8.75e-11 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs910187 0.678 rs8115769 chr20:45813704 A/C cg27589058 chr20:45804311 EYA2 -0.39 -7.55 -0.38 4.27e-13 Migraine; CRC cis rs7666738 0.830 rs4699591 chr4:98974171 A/G cg17366294 chr4:99064904 C4orf37 0.44 7.44 0.38 8.98e-13 Colonoscopy-negative controls vs population controls; CRC cis rs736408 0.736 rs4687550 chr3:52823430 T/G cg11645453 chr3:52864694 ITIH4 0.4 6.81 0.35 4.65e-11 Bipolar disorder; CRC cis rs13082711 0.513 rs66472045 chr3:27242887 G/A cg02860705 chr3:27208620 NA 0.65 9.1 0.45 9.13e-18 Systolic blood pressure;Diastolic blood pressure;Blood pressure; CRC cis rs7493 1.000 rs17166875 chr7:95041271 C/T cg21856205 chr7:94953877 PON1 -0.49 -6.31 -0.33 8.83e-10 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs10771431 0.597 rs10771413 chr12:9354413 C/T cg22349387 chr12:9600060 DDX12 -0.36 -5.65 -0.3 3.41e-8 Breast size; CRC cis rs13082711 0.689 rs34946790 chr3:27345170 G/A cg02860705 chr3:27208620 NA 0.88 10.91 0.52 7.35e-24 Systolic blood pressure;Diastolic blood pressure;Blood pressure; CRC cis rs4665809 0.818 rs35413760 chr2:26267137 C/A cg26119090 chr2:26468346 HADHA;HADHB 0.64 7.02 0.36 1.28e-11 Gut microbiome composition (summer); CRC cis rs796364 0.806 rs203766 chr2:200902672 T/C cg12253985 chr2:200820533 C2orf60;C2orf47 -0.57 -5.62 -0.3 4.18e-8 Schizophrenia; CRC cis rs9858542 1.000 rs11718165 chr3:49696797 A/G cg00383909 chr3:49044727 WDR6 0.45 5.63 0.3 3.93e-8 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs12291225 0.679 rs34238445 chr11:14315915 C/T cg05501817 chr11:14380813 RRAS2 -0.46 -6.11 -0.32 2.87e-9 Sense of smell; CRC cis rs7223966 1.000 rs8066719 chr17:61825764 C/T cg23090583 chr17:61904693 PSMC5;FTSJ3 0.5 6.17 0.32 2.02e-9 Hip circumference adjusted for BMI;Body mass index; CRC cis rs12497850 0.931 rs9876848 chr3:48844059 G/A cg07636037 chr3:49044803 WDR6 1.03 18.33 0.71 3.39e-52 Parkinson's disease; CRC cis rs9486715 1.000 rs6905568 chr6:97066382 T/C cg06623918 chr6:96969491 KIAA0776 -0.9 -14.88 -0.63 1.14e-38 Headache; CRC cis rs7909074 0.898 rs10793565 chr10:45388231 G/C cg05187965 chr10:45406764 TMEM72 -0.37 -8.69 -0.43 1.71e-16 Mean corpuscular volume; CRC cis rs2153535 0.580 rs6912193 chr6:8456306 T/G cg07606381 chr6:8435919 SLC35B3 0.68 10.91 0.52 7.29e-24 Motion sickness; CRC cis rs780094 0.544 rs780108 chr2:27684957 T/C cg12000995 chr2:27665139 KRTCAP3 -0.29 -6.1 -0.32 3.03e-9 Calcium levels;Fasting blood insulin;Metabolic traits;Triglyceride levels;Fasting plasma glucose;Urate levels in overweight individuals;Urate levels in obese individuals;Uric acid levels;Height;Age-related diseases, mortality and associated endophenotypes;Renal underexcretion gout;Fasting blood glucose (BMI interaction);Urate levels;Gondoic acid (20:1n-9) levels;Fasting blood insulin (BMI interaction);Triglycerides;Plasma omega-3 polyunsaturated fatty acid levels (docosapentaenoic acid);Type 2 diabetes;Nonalcoholic fatty liver disease;Hypertriglyceridemia;C-reactive protein;Age-related disease endophenotypes;LDL cholesterol;Metabolic syndrome;Crohn's disease;Alcohol consumption (drinks per week);Homeostasis model assessment of insulin resistance;Alcohol consumption;Red blood cell count;Fasting blood glucose; CRC cis rs9858542 1.000 rs1131095 chr3:49714225 T/C cg03060546 chr3:49711283 APEH -0.53 -7.11 -0.37 7.16e-12 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs9733 0.650 rs9803935 chr1:150552622 T/G cg17724175 chr1:150552817 MCL1 -0.5 -8.16 -0.41 7.11e-15 Tonsillectomy; CRC cis rs11098499 0.863 rs58452170 chr4:120459674 A/T cg09307838 chr4:120376055 NA 0.67 10.34 0.5 6.89e-22 Corneal astigmatism; CRC cis rs17713451 0.593 rs78219774 chr7:151279032 T/A cg18404559 chr7:151322523 PRKAG2 -0.55 -6.3 -0.33 9.43e-10 Interleukin-4 levels; CRC cis rs7772486 0.686 rs857875 chr6:145980033 T/G cg13319975 chr6:146136371 FBXO30 0.44 6.68 0.35 1.04e-10 Lobe attachment (rater-scored or self-reported); CRC cis rs427941 0.550 rs201515 chr7:101769164 G/A cg06246474 chr7:101738831 CUX1 0.37 5.66 0.3 3.27e-8 Plasma omega-3 polyunsaturated fatty acid level (eicosapentaenoic acid); CRC cis rs3733585 0.624 rs58130873 chr4:9972081 T/C cg00071950 chr4:10020882 SLC2A9 -0.54 -9.56 -0.47 2.93e-19 Cleft plate (environmental tobacco smoke interaction); CRC cis rs9291683 0.552 rs10939656 chr4:10014646 A/C cg11266682 chr4:10021025 SLC2A9 0.53 11.38 0.53 1.6e-25 Bone mineral density; CRC cis rs6088580 0.634 rs6059867 chr20:33078103 C/T cg24642439 chr20:33292090 TP53INP2 0.42 7.05 0.36 1.08e-11 Glomerular filtration rate (creatinine); CRC trans rs800082 1.000 rs1961653 chr3:144286098 C/T cg24215973 chr2:240111563 HDAC4 -0.51 -7.14 -0.37 5.94e-12 Smoking behavior; CRC cis rs7705042 0.865 rs9324866 chr5:141497650 A/G cg07392085 chr5:141489673 NDFIP1 0.47 7.43 0.38 9.4e-13 Asthma; CRC cis rs4665809 1.000 rs750451 chr2:26324241 G/A cg04944784 chr2:26401820 FAM59B -0.6 -7.67 -0.39 1.98e-13 Gut microbiome composition (summer); CRC trans rs9395066 0.545 rs12209076 chr6:44833423 G/A cg04786201 chr1:17185605 NA 0.28 6.04 0.32 4.21e-9 Height; CRC trans rs4650994 0.544 rs11579513 chr1:178496092 T/C cg05059571 chr16:84539110 KIAA1609 -0.56 -7.81 -0.4 7.49e-14 HDL cholesterol levels;HDL cholesterol; CRC cis rs11123610 0.520 rs66646194 chr2:3720420 G/A cg19052272 chr2:3704530 ALLC -0.62 -7.64 -0.39 2.34e-13 Response to inhaled corticosteroid treatment in asthma (change in FEV1); CRC cis rs61656020 1 rs61656020 chr16:1882221 C/G cg26897989 chr16:1907736 C16orf73 -0.53 -6.59 -0.34 1.8e-10 Ankle injury; CRC cis rs9902453 0.791 rs28492945 chr17:28223982 T/G cg26525008 chr17:28256777 EFCAB5;SSH2 0.66 10.57 0.5 1.14e-22 Coffee consumption (cups per day); CRC cis rs9486719 0.552 rs9399923 chr6:96850379 G/A cg06623918 chr6:96969491 KIAA0776 0.74 9.58 0.47 2.38e-19 Migraine;Coronary artery disease; CRC cis rs34233420 1 rs34233420 chr17:38004929 GATTT/G cg11212589 chr17:38028394 ZPBP2 0.37 6.75 0.35 6.63e-11 Lymphocyte counts; CRC cis rs17345786 0.861 rs74768235 chr3:101142821 T/C cg12386194 chr3:101231763 SENP7 0.53 6.77 0.35 5.86e-11 Colonoscopy-negative controls vs population controls; CRC cis rs9549260 0.755 rs17061503 chr13:41246758 A/G cg21288729 chr13:41239152 FOXO1 -0.48 -7.45 -0.38 8.27e-13 Red blood cell count; CRC cis rs2153535 0.563 rs1796687 chr6:8536118 C/G cg07606381 chr6:8435919 SLC35B3 0.69 11.2 0.53 6.71e-25 Motion sickness; CRC cis rs597539 0.690 rs647661 chr11:68625875 T/C cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.85 14.08 0.61 1.51e-35 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs4713118 0.513 rs149942 chr6:28001610 T/C cg20615401 chr6:28092323 ZSCAN16 0.46 6.23 0.32 1.47e-9 Parkinson's disease; CRC cis rs11122272 0.735 rs973252 chr1:231520802 A/G cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.54 -8.09 -0.41 1.18e-14 Hemoglobin concentration; CRC trans rs75804782 0.641 rs55844289 chr2:239323207 C/T cg01134436 chr17:81009848 B3GNTL1 0.75 7.05 0.36 1.08e-11 Morning vs. evening chronotype;Chronotype; CRC cis rs6732160 0.588 rs13403748 chr2:73371475 T/C cg01422370 chr2:73384389 NA 0.37 5.83 0.31 1.35e-8 Intelligence (multi-trait analysis); CRC cis rs4819052 0.851 rs7275874 chr21:46671223 C/T cg19498844 chr21:46707878 POFUT2;LOC642852 0.75 10.82 0.51 1.49e-23 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs853679 0.517 rs9366715 chr6:28064633 A/G cg21251018 chr6:28226885 NKAPL 0.48 6.26 0.33 1.17e-9 Depression; CRC cis rs9837602 1.000 rs13323143 chr3:99811553 T/C cg07805332 chr3:99536008 MIR548G;C3orf26 -0.47 -6.2 -0.32 1.68e-9 Breast cancer; CRC cis rs270601 0.721 rs270621 chr5:131605821 C/A cg22638593 chr5:131593259 PDLIM4 0.5 8.7 0.43 1.57e-16 Acylcarnitine levels; CRC cis rs1670533 1.000 rs1010342 chr4:1068819 C/T cg27284194 chr4:1044797 NA 0.5 6.41 0.33 4.99e-10 Recombination rate (females); CRC cis rs1881797 0.932 rs4551631 chr1:247667663 C/T cg11166453 chr1:247681781 NA -0.47 -8.22 -0.41 4.81e-15 Acute lymphoblastic leukemia (childhood); CRC cis rs61160187 0.582 rs1382917 chr5:60252495 A/G cg16298547 chr5:60138761 ELOVL7 -0.28 -5.88 -0.31 9.95e-9 Educational attainment (years of education);Educational attainment (college completion); CRC cis rs7086627 0.515 rs10887905 chr10:82210855 A/T cg09626299 chr10:82213104 TSPAN14 -0.37 -6.23 -0.33 1.39e-9 Post bronchodilator FEV1; CRC cis rs2535633 0.631 rs9823697 chr3:53002150 A/G cg05573699 chr3:52720067 GNL3;PBRM1 -0.38 -5.62 -0.3 4e-8 Body mass index; CRC cis rs6089584 0.925 rs35683654 chr20:60625401 G/T cg06108461 chr20:60628389 TAF4 0.84 12.5 0.57 1.28e-29 Body mass index; CRC cis rs6964587 1.000 rs2888851 chr7:91648341 G/A cg17063962 chr7:91808500 NA 0.8 14.27 0.62 2.79e-36 Breast cancer; CRC cis rs1712517 0.566 rs7917388 chr10:105054963 C/T cg04362960 chr10:104952993 NT5C2 -0.47 -6.15 -0.32 2.29e-9 Migraine; CRC cis rs3820068 0.581 rs16851855 chr1:15930869 G/A cg24675056 chr1:15929824 NA 0.49 6.77 0.35 5.87e-11 Systolic blood pressure; CRC cis rs1008375 1.000 rs2159584 chr4:17620568 G/A cg02297831 chr4:17616191 MED28 0.43 5.7 0.3 2.72e-8 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs2760061 0.598 rs673726 chr1:228120173 T/C cg02753203 chr1:228287806 NA -0.66 -10.07 -0.49 5.83e-21 Diastolic blood pressure; CRC cis rs6570726 0.791 rs9376953 chr6:145912226 G/T cg13319975 chr6:146136371 FBXO30 -0.44 -6.44 -0.33 4.13e-10 Lobe attachment (rater-scored or self-reported); CRC cis rs11997175 0.626 rs6468189 chr8:33648189 C/A ch.8.33884649F chr8:33765107 NA 0.4 6.23 0.32 1.45e-9 Body mass index; CRC cis rs4665809 0.549 rs7577896 chr2:26524493 C/T cg22920501 chr2:26401640 FAM59B 0.8 10.19 0.49 2.26e-21 Gut microbiome composition (summer); CRC cis rs2380220 0.576 rs7751219 chr6:96018915 G/A cg07718321 chr6:96025334 MANEA 0.59 7.49 0.38 6.54e-13 Behavioural disinhibition (generation interaction); CRC cis rs9788333 0.962 rs34853044 chr13:21883784 C/T cg23743428 chr13:21893420 NA -0.45 -8.7 -0.43 1.65e-16 Thiazide-induced adverse metabolic effects in hypertensive patients; CRC cis rs1475911 0.708 rs56185023 chr21:43521538 T/C cg24372256 chr21:43528868 UMODL1;C21orf128 -0.65 -9.95 -0.48 1.42e-20 IgG glycosylation; CRC cis rs2153535 0.580 rs1119688 chr6:8460850 T/C cg21535247 chr6:8435926 SLC35B3 0.49 7.43 0.38 9.44e-13 Motion sickness; CRC cis rs514406 0.825 rs28817407 chr1:53226116 G/A cg08859206 chr1:53392774 SCP2 0.42 6.56 0.34 2.14e-10 Monocyte count; CRC cis rs758324 0.504 rs55764014 chr5:131170905 G/T cg25547332 chr5:131281432 NA 0.35 5.68 0.3 3.03e-8 Alzheimer's disease in APOE e4- carriers; CRC cis rs4737010 0.501 rs7000282 chr8:41647493 A/C cg17182837 chr8:41585554 ANK1 -0.52 -6.89 -0.36 2.81e-11 Lymphocyte counts;High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Reticulocyte count;Reticulocyte fraction of red cells;Mean corpuscular volume;Immature fraction of reticulocytes;Mean corpuscular hemoglobin concentration; CRC cis rs12497850 0.931 rs9867373 chr3:48960938 A/T cg07636037 chr3:49044803 WDR6 1.03 18.47 0.71 9.49e-53 Parkinson's disease; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg16314058 chr1:43312353 ZNF691 0.45 6.14 0.32 2.42e-9 Anxiety disorder; CRC cis rs6502050 0.871 rs6502056 chr17:80070912 C/G cg02741985 chr17:80059408 CCDC57 -0.44 -7.07 -0.36 9.19e-12 Life satisfaction; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg26459430 chr19:680063 FSTL3 0.44 6.28 0.33 1.08e-9 Anxiety disorder; CRC trans rs10983614 1.000 rs7867776 chr9:120072627 A/G cg01844098 chr20:5987246 CRLS1 0.49 6.42 0.33 4.75e-10 Survival in pancreatic cancer; CRC cis rs12048904 0.595 rs2295280 chr1:101342497 T/C cg00063077 chr1:101360652 SLC30A7;EXTL2 0.7 10.84 0.51 1.26e-23 Multiple sclerosis; CRC cis rs6964587 0.839 rs6949700 chr7:91467435 A/G cg17063962 chr7:91808500 NA 0.7 11.59 0.54 2.91e-26 Breast cancer; CRC cis rs1799949 0.965 rs11657883 chr17:41330024 T/C cg25072359 chr17:41440525 NA 0.43 6.36 0.33 6.77e-10 Menopause (age at onset); CRC cis rs4689388 0.926 rs10937718 chr4:6295217 T/C cg00701064 chr4:6280414 WFS1 0.75 13.24 0.59 2.21e-32 Type 2 diabetes and other traits;Type 2 diabetes; CRC cis rs4319547 0.695 rs11058034 chr12:122894936 G/T cg05707623 chr12:122985044 ZCCHC8 0.75 8.4 0.42 1.35e-15 Body mass index; CRC cis rs75920871 0.588 rs7118591 chr11:116908457 A/C cg01368799 chr11:117014884 PAFAH1B2 0.42 5.9 0.31 9.09e-9 Subjective well-being; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg21354621 chr12:46384284 SFRS2IP 0.49 6.5 0.34 3.01e-10 Thyroid stimulating hormone; CRC cis rs858239 0.698 rs4265084 chr7:23407240 G/C cg00469287 chr7:23338798 C7orf30 0.46 6.11 0.32 2.85e-9 Cerebrospinal fluid biomarker levels; CRC cis rs6674176 0.696 rs4448553 chr1:44411589 A/G cg13606994 chr1:44402422 ARTN -0.37 -6.28 -0.33 1.09e-9 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Cognitive ability; CRC cis rs531930 0.959 rs506292 chr6:124735082 T/C cg22366943 chr6:124882293 NKAIN2 -0.43 -5.86 -0.31 1.1e-8 Celiac disease; CRC cis rs2859741 0.528 rs3753776 chr1:37480144 C/T cg09363841 chr1:37513479 NA -0.45 -6.97 -0.36 1.78e-11 Forced expiratory volume in 1 second (environmental tobacco smoke interaction); CRC cis rs68170813 0.605 rs2299428 chr7:107134384 A/G cg02696742 chr7:106810147 HBP1 -0.56 -5.96 -0.31 6.43e-9 Coronary artery disease; CRC cis rs7927771 0.864 rs7107726 chr11:47429245 T/A cg05585544 chr11:47624801 NA -0.55 -9.78 -0.47 5.26e-20 Subjective well-being; CRC cis rs9486719 0.857 rs4346856 chr6:96880270 C/T cg06623918 chr6:96969491 KIAA0776 0.85 12.67 0.57 3.16e-30 Migraine;Coronary artery disease; CRC cis rs698833 0.926 rs786626 chr2:44604066 C/G cg04920474 chr2:44395004 PPM1B 0.42 6.2 0.32 1.67e-9 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; CRC trans rs6550704 0.687 rs9865314 chr3:22634337 A/G cg15358743 chr18:56807035 SEC11C -0.39 -6.03 -0.32 4.35e-9 Daytime sleep phenotypes; CRC cis rs79349575 0.777 rs28517720 chr17:46976756 C/G cg22482690 chr17:47019901 SNF8 0.48 8.08 0.41 1.21e-14 Type 2 diabetes; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg00436663 chr22:38793933 LOC400927 0.46 6.93 0.36 2.27e-11 Liver disease severity in Alagille syndrome; CRC cis rs6893807 1.000 rs1422192 chr5:87959023 G/A cg09002922 chr5:87956389 LOC645323 -0.45 -6.55 -0.34 2.19e-10 Body mass index; CRC cis rs7586879 0.616 rs6722587 chr2:25132192 C/A cg22495460 chr2:25135724 ADCY3 -0.88 -17.44 -0.69 1.05e-48 Body mass index; CRC cis rs1552244 1.000 rs12374115 chr3:10134766 A/G cg08888203 chr3:10149979 C3orf24 -0.65 -9.03 -0.45 1.51e-17 Alzheimer's disease; CRC cis rs7662987 0.517 rs2602865 chr4:100034841 T/C cg13256891 chr4:100009986 ADH5 0.63 8.54 0.43 4.99e-16 Smoking initiation; CRC cis rs929354 0.772 rs4716460 chr7:156970054 T/C cg16102536 chr7:156981717 UBE3C 0.4 6.69 0.35 9.57e-11 Body mass index; CRC cis rs2228479 0.850 rs17226428 chr16:89842884 T/A cg06558623 chr16:89946397 TCF25 1.09 10.23 0.49 1.69e-21 Skin colour saturation; CRC cis rs1538970 0.851 rs61788285 chr1:45919234 A/C cg05343316 chr1:45956843 TESK2 0.76 10.21 0.49 1.96e-21 Platelet count; CRC trans rs800082 0.698 rs800070 chr3:144346614 A/T cg24215973 chr2:240111563 HDAC4 -0.74 -10.45 -0.5 2.97e-22 Smoking behavior; CRC cis rs3093024 0.874 rs3093018 chr6:167539805 C/T cg07741184 chr6:167504864 NA -0.34 -6.0 -0.31 5.07e-9 Rheumatoid arthritis; CRC trans rs58688157 0.705 rs936469 chr11:606749 G/A cg19188899 chr13:112838565 NA -0.43 -6.76 -0.35 6.41e-11 Systemic lupus erythematosus; CRC cis rs28830936 1.000 rs4924570 chr15:41974660 A/G cg17847044 chr15:42102381 MAPKBP1 -0.29 -6.38 -0.33 6.09e-10 Diastolic blood pressure; CRC cis rs7727544 0.709 rs272852 chr5:131688767 G/A cg04518342 chr5:131593106 PDLIM4 0.33 5.82 0.31 1.41e-8 Blood metabolite levels; CRC cis rs7586879 0.616 rs11900505 chr2:25131986 A/C cg22495460 chr2:25135724 ADCY3 -0.87 -17.01 -0.68 5.43e-47 Body mass index; CRC cis rs7894051 0.717 rs35297981 chr10:135150600 T/G cg24905316 chr10:135186343 ECHS1 -0.72 -5.9 -0.31 8.92e-9 Lifespan; CRC cis rs1448094 0.511 rs11117042 chr12:86207547 G/T cg19622623 chr12:86230825 RASSF9 -0.35 -5.63 -0.3 3.79e-8 Major depressive disorder; CRC cis rs9486719 0.857 rs6568392 chr6:96861476 G/T cg06623918 chr6:96969491 KIAA0776 0.81 11.48 0.53 7.1e-26 Migraine;Coronary artery disease; CRC cis rs7173389 1.000 rs7174098 chr15:73664041 G/A cg01796676 chr15:73680284 NA 0.55 7.12 0.37 6.96e-12 Resting heart rate; CRC trans rs9951602 0.512 rs8097996 chr18:76648035 A/G cg02800362 chr5:177631904 HNRNPAB 0.72 10.34 0.5 6.97e-22 Obesity-related traits; CRC cis rs561341 0.882 rs28649357 chr17:30367190 A/G cg19193384 chr17:30244184 NA -0.54 -6.95 -0.36 2.02e-11 Hip circumference adjusted for BMI; CRC cis rs57994353 0.667 rs34985258 chr9:139327154 C/T cg13611204 chr9:139324423 INPP5E -0.42 -5.9 -0.31 8.84e-9 Eosinophil counts;Cutaneous squamous cell carcinoma; CRC cis rs9902453 0.817 rs880749 chr17:28059970 T/C cg26525008 chr17:28256777 EFCAB5;SSH2 -0.58 -8.72 -0.43 1.43e-16 Coffee consumption (cups per day); CRC cis rs2735413 0.752 rs11642442 chr16:78080800 A/C cg04733911 chr16:78082701 NA -0.44 -7.37 -0.38 1.38e-12 Systolic blood pressure (alcohol consumption interaction); CRC cis rs282587 0.597 rs12876520 chr13:113393566 C/G cg04656015 chr13:113407548 ATP11A 0.61 7.39 0.38 1.23e-12 Glycated hemoglobin levels; CRC cis rs798554 0.959 rs798556 chr7:2759002 C/A cg14895029 chr7:2775587 GNA12 -0.41 -6.14 -0.32 2.34e-9 Height; CRC cis rs951366 0.617 rs9438393 chr1:205782718 A/G cg24503407 chr1:205819492 PM20D1 1.0 17.77 0.7 5.15e-50 Menarche (age at onset); CRC cis rs2228479 0.850 rs11639906 chr16:89798183 T/C cg06558623 chr16:89946397 TCF25 1.16 10.93 0.52 6.45e-24 Skin colour saturation; CRC cis rs6502050 0.749 rs7209948 chr17:80086804 T/G cg13198984 chr17:80129470 CCDC57 -0.48 -8.55 -0.43 4.57e-16 Life satisfaction; CRC trans rs11088226 0.681 rs74779447 chr21:33929013 G/A cg09050820 chr6:167586206 TCP10L2 0.84 8.99 0.44 1.96e-17 Gastritis; CRC cis rs7666738 0.830 rs34870112 chr4:99045815 T/G cg05340658 chr4:99064831 C4orf37 0.6 9.35 0.46 1.4e-18 Colonoscopy-negative controls vs population controls; CRC cis rs1044826 0.642 rs9859864 chr3:139091219 G/T cg00490450 chr3:139108681 COPB2 -0.48 -7.21 -0.37 3.94e-12 Obesity-related traits; CRC cis rs875971 1.000 rs10257427 chr7:65743208 T/C cg18912574 chr7:65842487 NCRNA00174 -0.37 -6.33 -0.33 7.93e-10 Aortic root size; CRC cis rs1552244 1.000 rs112509186 chr3:10156533 A/G cg16606324 chr3:10149918 C3orf24 0.72 9.5 0.46 4.68e-19 Alzheimer's disease; CRC cis rs7112925 0.932 rs12287978 chr11:66833327 G/A cg24851651 chr11:66362959 CCS -0.38 -6.56 -0.34 2.14e-10 Height; CRC trans rs1005277 0.505 rs200936 chr10:38134935 T/C cg27523141 chr10:43048294 ZNF37B 0.45 6.53 0.34 2.47e-10 Extrinsic epigenetic age acceleration; CRC cis rs929354 0.605 rs7806314 chr7:156946903 A/T cg16102536 chr7:156981717 UBE3C 0.4 6.69 0.35 9.57e-11 Body mass index; CRC cis rs7613875 0.600 rs2856237 chr3:50158774 A/G cg05623727 chr3:50126028 RBM5 -0.59 -10.35 -0.5 6.63e-22 Body mass index; CRC cis rs1729951 0.575 rs361237 chr3:136702414 A/G cg21827317 chr3:136751795 NA 0.35 5.76 0.3 1.89e-8 Neuroticism; CRC cis rs8077889 0.672 rs2074143 chr17:41856622 A/G cg25876840 chr17:41920477 NA 0.36 5.67 0.3 3.11e-8 Triglycerides; CRC cis rs524023 1.000 rs3825018 chr11:64358809 G/A cg06522879 chr11:64358276 SLC22A12 -0.59 -9.38 -0.46 1.11e-18 Urate levels in obese individuals; CRC cis rs1448094 0.967 rs11117116 chr12:86331087 A/T cg02569458 chr12:86230093 RASSF9 0.37 6.47 0.34 3.47e-10 Major depressive disorder; CRC cis rs11711311 0.955 rs12630833 chr3:113390883 G/T cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.53 -6.94 -0.36 2.15e-11 IgG glycosylation; CRC cis rs4474465 1.000 rs10793314 chr11:78174196 G/C cg27205649 chr11:78285834 NARS2 -0.48 -5.85 -0.31 1.18e-8 Alzheimer's disease (survival time); CRC cis rs116095464 0.558 rs13357299 chr5:242211 T/C cg22496380 chr5:211416 CCDC127 -0.87 -10.12 -0.49 3.87e-21 Breast cancer; CRC cis rs908922 0.676 rs1337340 chr1:152508260 T/C cg09873164 chr1:152488093 CRCT1 0.38 6.35 0.33 7.21e-10 Hair morphology; CRC trans rs1455244 0.700 rs7229302 chr18:11508904 G/T cg02125727 chr4:47916636 NFXL1 0.41 6.1 0.32 2.98e-9 Schizophrenia; CRC cis rs9911578 0.935 rs9911753 chr17:56983174 G/A cg05425664 chr17:57184151 TRIM37 -0.43 -6.74 -0.35 7.05e-11 Intelligence (multi-trait analysis); CRC cis rs4654899 0.714 rs12123093 chr1:21114416 C/T cg02927042 chr1:21476669 EIF4G3 -0.48 -7.62 -0.39 2.78e-13 Superior frontal gyrus grey matter volume; CRC cis rs2070488 0.965 rs7372849 chr3:38524328 G/C cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.86 16.11 0.66 1.94e-43 Electrocardiographic conduction measures; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg24037629 chr17:48226544 PPP1R9B 0.48 7.07 0.36 9.61e-12 Response to antipsychotic treatment; CRC cis rs802075 0.967 rs187233 chr6:49659703 C/T cg20364632 chr6:49636226 NA -0.36 -5.88 -0.31 9.95e-9 Bone mineral density (hip) and age at menarche; CRC cis rs9902453 1.000 rs4795525 chr17:28388487 T/A cg26525008 chr17:28256777 EFCAB5;SSH2 -0.59 -8.86 -0.44 4.95e-17 Coffee consumption (cups per day); CRC trans rs916888 0.821 rs199513 chr17:44856932 A/G cg01341218 chr17:43662625 NA -0.78 -9.14 -0.45 6.41e-18 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs1799949 1.000 rs1824889 chr17:41421876 C/G cg19454999 chr17:41278357 BRCA1;NBR2 0.52 8.14 0.41 8.16e-15 Menopause (age at onset); CRC cis rs2842992 0.789 rs9365093 chr6:160175819 C/G cg19482086 chr6:160211437 TCP1;MRPL18 0.73 9.55 0.47 3.12e-19 Age-related macular degeneration (geographic atrophy); CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg04175895 chr11:64851783 CDCA5;ZFPL1 0.48 6.43 0.33 4.55e-10 Anxiety disorder; CRC cis rs13108904 0.935 rs6853002 chr4:1295991 C/T cg20092199 chr4:1342459 KIAA1530 0.37 6.54 0.34 2.42e-10 Obesity-related traits; CRC cis rs2404602 0.647 rs11631394 chr15:76973209 G/T cg03037974 chr15:76606532 NA -0.53 -8.21 -0.41 5.15e-15 Blood metabolite levels; CRC cis rs12926788 0.546 rs200531 chr16:24756172 G/A cg06028605 chr16:24865363 SLC5A11 -0.6 -10.0 -0.48 9.84e-21 Ejection fraction in Tripanosoma cruzi seropositivity; CRC trans rs11098499 0.909 rs35111518 chr4:120440682 A/G cg25214090 chr10:38739885 LOC399744 0.64 9.9 0.48 2.14e-20 Corneal astigmatism; CRC cis rs2070488 1.000 rs1002676 chr3:38444932 A/C cg01465620 chr3:38496096 LOC100128640;ACVR2B -0.88 -15.98 -0.66 5.79e-43 Electrocardiographic conduction measures; CRC cis rs2075371 0.501 rs1646653 chr7:134024686 A/G cg20476274 chr7:133979776 SLC35B4 0.59 9.18 0.45 4.83e-18 Mean platelet volume; CRC cis rs1009181 0.585 rs72834696 chr6:26161399 G/A cg13736514 chr6:26305472 NA -0.4 -5.89 -0.31 9.36e-9 Childhood ear infection; CRC cis rs11105298 0.891 rs10858879 chr12:89886578 A/T cg08166232 chr12:89918718 WDR51B;GALNT4 0.58 7.56 0.38 4.06e-13 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg05712126 chr22:29601860 EMID1 0.42 6.98 0.36 1.64e-11 Liver disease severity in Alagille syndrome; CRC cis rs9486719 1.000 rs11152951 chr6:96894135 C/G cg06623918 chr6:96969491 KIAA0776 -0.81 -9.51 -0.46 4.17e-19 Migraine;Coronary artery disease; CRC cis rs4862750 0.914 rs1991256 chr4:187875330 A/G cg22105103 chr4:187893119 NA 0.63 11.29 0.53 3.27e-25 Lobe attachment (rater-scored or self-reported); CRC cis rs9467603 1.000 rs9467607 chr6:25809477 G/A cg16898833 chr6:26189333 HIST1H4D 0.77 6.45 0.33 4.07e-10 Intelligence (multi-trait analysis); CRC cis rs62064224 0.675 rs12150479 chr17:30636200 T/A cg12855166 chr17:30846586 MYO1D -0.38 -6.44 -0.33 4.27e-10 Schizophrenia; CRC cis rs780096 0.526 rs704795 chr2:27716494 G/A cg17158414 chr2:27665306 KRTCAP3 -0.3 -6.48 -0.34 3.3e-10 Total body bone mineral density; CRC cis rs9549260 0.755 rs17061491 chr13:41228210 T/A cg21288729 chr13:41239152 FOXO1 0.49 7.68 0.39 1.89e-13 Red blood cell count; CRC cis rs2760061 0.545 rs1745423 chr1:228224153 G/T cg02753203 chr1:228287806 NA -0.85 -13.1 -0.59 7.41e-32 Diastolic blood pressure; CRC trans rs3858526 0.959 rs61876224 chr11:5952859 G/A cg01505111 chr6:125621795 HDDC2 0.39 6.13 0.32 2.51e-9 DNA methylation (variation); CRC trans rs62103177 0.810 rs3902996 chr18:77630571 A/G cg05926928 chr17:57297772 GDPD1 1.06 9.98 0.48 1.12e-20 Opioid sensitivity; CRC cis rs2408955 0.522 rs10875721 chr12:48413593 A/G cg24011408 chr12:48396354 COL2A1 -0.46 -6.67 -0.35 1.1e-10 Glycated hemoglobin levels; CRC cis rs881375 0.933 rs10818485 chr9:123667816 G/C cg09586646 chr9:123605570 PSMD5;LOC253039 0.53 7.17 0.37 5.01e-12 Rheumatoid arthritis; CRC cis rs10206020 0.921 rs72778005 chr2:1573122 C/G cg12573674 chr2:1569213 NA -0.78 -10.26 -0.49 1.3e-21 IgG glycosylation; CRC cis rs7715806 0.500 rs72633985 chr5:75006384 A/G cg19683494 chr5:74908142 NA 0.51 5.76 0.3 1.89e-8 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC trans rs2303319 0.504 rs62189048 chr2:162613494 G/C cg27342122 chr8:133787442 PHF20L1 -0.72 -6.12 -0.32 2.68e-9 Cognitive function; CRC trans rs2727020 0.894 rs3862342 chr11:49357043 C/T cg15704280 chr7:45808275 SEPT13 -0.76 -10.21 -0.49 1.99e-21 Coronary artery disease; CRC cis rs79349575 0.783 rs9912829 chr17:46982749 G/C cg00947319 chr17:47005597 UBE2Z -0.34 -5.91 -0.31 8.38e-9 Type 2 diabetes; CRC cis rs10751667 0.643 rs10794352 chr11:946294 T/C cg06064525 chr11:970664 AP2A2 -0.31 -6.37 -0.33 6.36e-10 Alzheimer's disease (late onset); CRC cis rs1465370 0.750 rs3807136 chr7:130019481 C/T cg03229158 chr7:130009420 NA 0.43 6.09 0.32 3.22e-9 Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction);Waist circumference adjusted for BMI in active individuals;Waist circumference adjusted for body mass index; CRC cis rs4665809 1.000 rs4665817 chr2:26305167 G/A cg22920501 chr2:26401640 FAM59B -0.56 -7.36 -0.38 1.48e-12 Gut microbiome composition (summer); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg05253283 chr3:195717344 SDHAP1 0.43 6.26 0.33 1.22e-9 Intelligence (multi-trait analysis); CRC cis rs758324 0.898 rs510434 chr5:131292503 C/T cg25547332 chr5:131281432 NA -0.38 -5.62 -0.3 4.18e-8 Alzheimer's disease in APOE e4- carriers; CRC cis rs13108904 0.517 rs4974551 chr4:1336410 C/A cg23123621 chr4:1343375 KIAA1530 0.35 5.65 0.3 3.47e-8 Obesity-related traits; CRC cis rs12497850 1.000 rs12497850 chr3:48748989 G/T cg07636037 chr3:49044803 WDR6 0.94 16.01 0.66 4.61e-43 Parkinson's disease; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg26056348 chr7:75932317 HSPB1 0.43 6.15 0.32 2.31e-9 Anxiety disorder; CRC cis rs17331151 0.541 rs11709430 chr3:52862055 G/A cg06204229 chr3:52865917 ITIH4 0.57 7.88 0.4 4.95e-14 Immune reponse to smallpox (secreted IL-2); CRC cis rs9818758 0.607 rs9311439 chr3:49310408 A/G cg07636037 chr3:49044803 WDR6 -0.72 -6.08 -0.32 3.38e-9 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; CRC cis rs17401966 0.838 rs9332414 chr1:10326963 C/T cg19773385 chr1:10388646 KIF1B -0.66 -10.76 -0.51 2.38e-23 Hepatocellular carcinoma; CRC cis rs67478160 0.643 rs6575997 chr14:104228546 C/T cg08213375 chr14:104286397 PPP1R13B -0.67 -13.81 -0.61 1.54e-34 Schizophrenia; CRC cis rs9640161 0.789 rs3735174 chr7:150020489 T/C cg13722127 chr7:150037890 RARRES2 0.48 7.78 0.39 9.7e-14 Blood protein levels;Circulating chemerin levels; CRC cis rs61160187 0.610 rs4700399 chr5:60136454 C/T cg16298547 chr5:60138761 ELOVL7 -0.29 -6.14 -0.32 2.32e-9 Educational attainment (years of education);Educational attainment (college completion); CRC cis rs747650 0.892 rs2029298 chr11:47234718 C/T cg19486271 chr11:47235900 DDB2 -0.51 -7.76 -0.39 1.1e-13 Acne (severe); CRC cis rs12541635 0.966 rs1603363 chr8:107031319 A/G cg10147462 chr8:107024639 NA 0.45 7.51 0.38 5.57e-13 Age of smoking initiation; CRC cis rs7113874 0.569 rs10840072 chr11:8569360 T/C cg20771178 chr11:8615675 STK33 -0.34 -5.6 -0.3 4.41e-8 Body mass index in physically active individuals;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs798554 0.704 rs2527684 chr7:2825922 G/T cg13628971 chr7:2884303 GNA12 0.38 5.84 0.31 1.24e-8 Height; CRC cis rs13108904 0.967 rs4974582 chr4:1279687 C/T cg21620606 chr4:1342894 KIAA1530 0.36 5.91 0.31 8.57e-9 Obesity-related traits; CRC cis rs9362426 0.708 rs7744793 chr6:88102040 G/A cg08069147 chr6:88032118 GJB7;C6orf162 0.47 6.13 0.32 2.52e-9 Depressive episodes in bipolar disorder; CRC cis rs1559088 0.600 rs7246566 chr19:33589618 A/T cg27124370 chr19:33622961 WDR88 0.48 6.9 0.36 2.73e-11 Bone ultrasound measurement (broadband ultrasound attenuation); CRC cis rs6674176 0.593 rs6675620 chr1:44417630 C/T cg15962314 chr1:44399869 ARTN 0.3 5.86 0.31 1.15e-8 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Cognitive ability; CRC trans rs1814175 0.817 rs12277258 chr11:49940216 T/C cg21153622 chr11:89784906 NA -0.37 -5.99 -0.31 5.61e-9 Height; CRC cis rs13096480 0.583 rs17598137 chr3:49891362 G/T cg27186011 chr3:49840712 C3orf54 0.37 5.85 0.31 1.17e-8 Intelligence (multi-trait analysis); CRC cis rs10504229 0.569 rs75466737 chr8:58055034 A/G cg11062466 chr8:58055876 NA 0.59 7.22 0.37 3.7e-12 Developmental language disorder (linguistic errors); CRC cis rs9611565 0.659 rs12483786 chr22:41938536 A/G cg17554472 chr22:41940697 POLR3H -0.56 -5.94 -0.31 7.15e-9 Vitiligo; CRC cis rs875971 0.522 rs1701760 chr7:65473688 A/G cg05627663 chr7:65219948 SNORA22;CCT6P1 0.49 7.35 0.38 1.62e-12 Aortic root size; CRC cis rs10504229 0.683 rs55986917 chr8:58137210 C/T cg02725872 chr8:58115012 NA -0.64 -11.55 -0.54 3.85e-26 Developmental language disorder (linguistic errors); CRC cis rs629535 0.862 rs2472141 chr8:70054216 T/C cg26132723 chr8:70041827 NA 0.36 5.8 0.3 1.6e-8 Dupuytren's disease; CRC cis rs853679 0.517 rs9368558 chr6:28133306 A/G cg15845792 chr6:28175446 NA 1.04 13.89 0.61 7.67e-35 Depression; CRC cis rs9304742 0.962 rs12461778 chr19:53454963 T/A cg09915433 chr19:53449742 NA -0.6 -9.1 -0.45 8.63e-18 Psoriasis; CRC cis rs9916302 0.904 rs7210488 chr17:37539819 T/G cg03013999 chr17:37608204 MED1 -0.47 -7.4 -0.38 1.14e-12 Glomerular filtration rate (creatinine); CRC cis rs2832191 0.692 rs8134627 chr21:30349069 C/T cg24692254 chr21:30365293 RNF160 -0.86 -16.17 -0.67 1.12e-43 Dental caries; CRC cis rs9650657 0.529 rs10108618 chr8:10953092 A/G cg27411982 chr8:10470053 RP1L1 -0.39 -6.3 -0.33 9.71e-10 Neuroticism; CRC cis rs35110281 0.667 rs2838354 chr21:45119857 T/C cg01579765 chr21:45077557 HSF2BP -0.32 -5.79 -0.3 1.68e-8 Mean corpuscular volume; CRC cis rs8067545 0.750 rs4925077 chr17:19982276 C/T cg13482628 chr17:19912719 NA 0.49 7.67 0.39 1.97e-13 Schizophrenia; CRC cis rs6545883 0.894 rs10496092 chr2:61524679 C/T cg15711740 chr2:61764176 XPO1 0.43 5.73 0.3 2.26e-8 Tuberculosis; CRC trans rs2553218 0.690 rs8032415 chr15:54851945 A/G cg03376565 chr6:26104165 HIST1H4C 0.49 6.53 0.34 2.45e-10 Immune response to smallpox vaccine (IL-6); CRC cis rs870825 0.932 rs28702958 chr4:185575562 C/T cg04058563 chr4:185651563 MLF1IP 0.63 6.44 0.33 4.3e-10 Blood protein levels; CRC cis rs9311474 0.508 rs11720159 chr3:52617802 T/G cg11645453 chr3:52864694 ITIH4 0.36 6.45 0.34 3.93e-10 Electroencephalogram traits; CRC cis rs11628318 0.515 rs60573537 chr14:103150407 A/G cg12046867 chr14:103022105 NA 0.4 5.69 0.3 2.87e-8 Platelet count; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg04567173 chr4:25379221 ANAPC4 0.4 6.6 0.34 1.64e-10 Liver disease severity in Alagille syndrome; CRC cis rs6740322 0.895 rs11684601 chr2:43574242 G/T cg06169590 chr2:43455088 ZFP36L2;LOC100129726 -0.63 -7.88 -0.4 4.69e-14 Coronary artery disease; CRC cis rs2576037 0.583 rs8086286 chr18:44467515 A/G cg23996704 chr18:44553084 KATNAL2 0.32 6.22 0.32 1.55e-9 Personality dimensions; CRC cis rs10504229 0.906 rs72650894 chr8:58179734 C/T cg24829409 chr8:58192753 C8orf71 -0.68 -11.34 -0.53 2.27e-25 Developmental language disorder (linguistic errors); CRC cis rs7772486 0.790 rs6570723 chr6:146151230 A/T cg13319975 chr6:146136371 FBXO30 -0.42 -6.26 -0.33 1.23e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs1552244 0.882 rs13062917 chr3:10017032 T/A cg10729496 chr3:10149963 C3orf24 0.48 6.25 0.33 1.25e-9 Alzheimer's disease; CRC cis rs5753037 0.639 rs5997534 chr22:30220190 G/A cg01021169 chr22:30184971 ASCC2 -0.43 -6.62 -0.34 1.43e-10 Type 1 diabetes; CRC cis rs7762018 0.514 rs60671539 chr6:170165981 A/G cg15038512 chr6:170123185 PHF10 0.46 6.54 0.34 2.39e-10 Thiazide-induced adverse metabolic effects in hypertensive patients; CRC cis rs11138902 0.649 rs13286400 chr9:72148579 C/G cg14123607 chr9:72164709 APBA1 0.41 6.0 0.31 5.27e-9 Intelligence;Cognitive ability;Intelligence (multi-trait analysis); CRC cis rs172166 0.516 rs2021826 chr6:28132756 G/A cg23161317 chr6:28129485 ZNF389 0.39 5.85 0.31 1.17e-8 Cardiac Troponin-T levels; CRC cis rs6860806 0.507 rs272891 chr5:131664394 G/T cg24060327 chr5:131705240 SLC22A5 -0.52 -7.8 -0.4 8.13e-14 Breast cancer; CRC cis rs10540 1.000 rs78520676 chr11:517173 G/A cg03934478 chr11:495069 RNH1 0.71 7.87 0.4 5.25e-14 Body mass index; CRC cis rs9660180 0.934 rs34849348 chr1:1762757 C/T cg17747265 chr1:1875780 NA -0.76 -12.83 -0.58 8.19e-31 Body mass index; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg00666446 chr1:247242273 ZNF670 0.46 6.51 0.34 2.87e-10 Response to antipsychotic treatment; CRC cis rs546131 1.000 rs546131 chr11:34851760 G/C cg24088639 chr11:34937564 PDHX;APIP -0.43 -6.0 -0.31 5.15e-9 Lung disease severity in cystic fibrosis; CRC cis rs7932354 0.528 rs7108902 chr11:47091571 C/T cg19486271 chr11:47235900 DDB2 -0.45 -6.46 -0.34 3.8e-10 Bone mineral density (hip);Bone mineral density; CRC cis rs7605827 0.930 rs10929366 chr2:15531754 C/T cg19274914 chr2:15703543 NA 0.39 5.76 0.3 1.98e-8 Educational attainment (years of education); CRC cis rs3858526 0.676 rs10838752 chr11:5887243 A/G cg26762873 chr11:5879799 OR52E8 -0.45 -6.55 -0.34 2.23e-10 DNA methylation (variation); CRC cis rs4148883 0.629 rs2602899 chr4:100010128 C/T cg13256891 chr4:100009986 ADH5 0.46 6.44 0.33 4.12e-10 Alcohol dependence; CRC cis rs629535 0.773 rs655299 chr8:70074534 C/T cg26132723 chr8:70041827 NA 0.35 5.71 0.3 2.51e-8 Dupuytren's disease; CRC cis rs7274811 0.711 rs373618 chr20:31992639 C/A cg07470512 chr20:32255052 NECAB3;C20orf134 0.43 5.83 0.31 1.29e-8 Height; CRC cis rs1862618 0.853 rs252887 chr5:56166188 A/G cg20203395 chr5:56204925 C5orf35 -0.72 -8.34 -0.42 2.08e-15 Initial pursuit acceleration; CRC cis rs6866614 0.608 rs17132288 chr5:131336105 C/T cg18758796 chr5:131593413 PDLIM4 0.33 5.83 0.31 1.3e-8 Perceived unattractiveness to mosquitoes; CRC cis rs7551222 0.749 rs6594019 chr1:204568610 T/C cg07972458 chr1:204535000 NA 0.37 5.7 0.3 2.65e-8 Schizophrenia; CRC cis rs67340775 0.541 rs200975 chr6:27855625 G/T cg15786705 chr6:28176104 NA 0.56 5.65 0.3 3.39e-8 Lung cancer in ever smokers; CRC cis rs13191362 0.872 rs35443919 chr6:163055804 C/T cg21926612 chr6:163149169 PACRG;PARK2 0.98 12.51 0.57 1.22e-29 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs10464366 0.544 rs953874 chr7:39147916 G/A cg20302533 chr7:39170763 POU6F2 0.4 5.66 0.3 3.33e-8 IgG glycosylation; CRC cis rs597539 0.652 rs501799 chr11:68631240 G/T cg06028808 chr11:68637592 NA 0.39 6.37 0.33 6.2e-10 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs9894429 1.000 rs11652797 chr17:79574124 A/G cg18240062 chr17:79603768 NPLOC4 0.54 9.1 0.45 8.85e-18 Eye color traits; CRC trans rs875971 0.660 rs2191268 chr7:66110224 C/T cg02756545 chr1:94884060 ABCD3 -0.4 -5.98 -0.31 5.7e-9 Aortic root size; CRC cis rs6565681 0.883 rs4523980 chr17:78347664 A/G cg15383979 chr17:78362278 RNF213;LOC100294362 -0.55 -6.32 -0.33 8.6e-10 Moyamoya disease; CRC trans rs4843747 0.749 rs12102841 chr16:88072574 C/G cg26811252 chr16:29126840 RRN3P2 -0.66 -9.16 -0.45 5.73e-18 Menopause (age at onset); CRC cis rs17443541 0.507 rs7576031 chr2:200470616 G/A cg03741458 chr2:200468445 NA -0.36 -5.77 -0.3 1.87e-8 Intelligence (multi-trait analysis); CRC cis rs10089 0.953 rs1432614 chr5:127416919 A/G cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.73 10.36 0.5 5.74e-22 Ileal carcinoids; CRC cis rs4604732 0.678 rs74154674 chr1:247625685 C/T cg02104434 chr1:247694406 LOC148824;OR2C3 0.6 8.82 0.44 6.67e-17 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CRC cis rs9517320 0.515 rs4771307 chr13:99221879 A/G cg07423050 chr13:99094983 FARP1 -0.55 -7.58 -0.39 3.56e-13 Longevity; CRC cis rs6011002 0.614 rs1291208 chr20:62330417 T/C cg01176363 chr20:62369445 LIME1 -0.74 -5.68 -0.3 3.04e-8 Dental caries; CRC cis rs17666538 1.000 rs59631161 chr8:587808 G/T cg26554054 chr8:600488 NA -0.66 -6.11 -0.32 2.85e-9 IgG glycosylation; CRC cis rs972578 1.000 rs5759070 chr22:43375701 G/A cg01576275 chr22:43409880 NA -0.49 -7.84 -0.4 6.52e-14 Mean platelet volume; CRC cis rs2836950 0.545 rs2836940 chr21:40588696 T/C cg17971929 chr21:40555470 PSMG1 -0.59 -8.63 -0.43 2.65e-16 Menarche (age at onset); CRC cis rs2836974 0.674 rs1011413 chr21:40638241 A/G cg11890956 chr21:40555474 PSMG1 -0.91 -15.89 -0.66 1.39e-42 Cognitive function; CRC cis rs270601 0.770 rs61352298 chr5:131600589 G/C cg22638593 chr5:131593259 PDLIM4 0.48 9.05 0.45 1.28e-17 Acylcarnitine levels; CRC cis rs1707322 0.752 rs6678444 chr1:46229847 A/G cg03146154 chr1:46216737 IPP 0.66 9.52 0.46 3.79e-19 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs35146811 0.735 rs1727140 chr7:99815399 T/A cg00553149 chr7:99775558 STAG3;GPC2 -0.24 -5.72 -0.3 2.42e-8 Coronary artery disease; CRC cis rs736408 0.527 rs2577831 chr3:52628056 C/A cg17372223 chr3:52568218 NT5DC2 0.39 5.97 0.31 6.29e-9 Bipolar disorder; CRC cis rs5769765 0.773 rs9616206 chr22:50310847 G/T cg04121214 chr22:50244548 NA 0.43 6.02 0.31 4.74e-9 Schizophrenia; CRC cis rs9322817 0.691 rs9391244 chr6:105257690 G/A cg02098413 chr6:105308735 HACE1 -0.44 -8.6 -0.43 3.29e-16 Thyroid stimulating hormone; CRC cis rs67311347 1.000 rs2276871 chr3:40499273 C/T cg24209194 chr3:40518798 ZNF619 0.43 6.56 0.34 2.12e-10 Renal cell carcinoma; CRC cis rs12908161 1.000 rs11638290 chr15:85227636 C/T cg11189052 chr15:85197271 WDR73 0.62 8.86 0.44 4.93e-17 Schizophrenia; CRC cis rs7998202 0.775 rs282580 chr13:113357540 T/C cg02820901 chr13:113351484 ATP11A 0.58 6.17 0.32 1.95e-9 Glycated hemoglobin levels; CRC cis rs1552244 1.000 rs113134644 chr3:10086286 G/A cg02579736 chr3:10068473 FANCD2;CIDECP 0.96 13.02 0.58 1.59e-31 Alzheimer's disease; CRC cis rs9549367 0.673 rs575453 chr13:113837871 C/A cg18105134 chr13:113819100 PROZ 0.87 13.56 0.6 1.39e-33 Platelet distribution width; CRC cis rs1552244 0.554 rs13079240 chr3:10047246 C/T cg18598329 chr3:10140678 FANCD2;C3orf24 -0.54 -7.63 -0.39 2.52e-13 Alzheimer's disease; CRC cis rs6665290 0.669 rs12406714 chr1:227177061 T/C cg10327440 chr1:227177885 CDC42BPA -0.99 -21.06 -0.76 5.95e-63 Myeloid white cell count; CRC cis rs9914988 0.887 rs7213285 chr17:27206029 G/A cg20469991 chr17:27169893 C17orf63 -0.6 -5.83 -0.31 1.32e-8 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC trans rs11148252 0.553 rs9536236 chr13:53255012 T/A cg18335740 chr13:41363409 SLC25A15 0.87 16.05 0.66 3.26e-43 Lewy body disease; CRC cis rs9926296 0.605 rs7205053 chr16:89856763 G/C cg04287289 chr16:89883240 FANCA 0.82 14.65 0.63 8.85e-38 Vitiligo; CRC cis rs34375054 0.526 rs883315 chr12:125676889 T/C cg05341575 chr12:125625032 AACS -0.38 -5.95 -0.31 6.79e-9 Post bronchodilator FEV1/FVC ratio; CRC cis rs72781680 0.898 rs72796166 chr2:23939311 G/C cg08917208 chr2:24149416 ATAD2B 0.99 9.37 0.46 1.21e-18 Lymphocyte counts; CRC cis rs17095355 1.000 rs11194940 chr10:111742223 G/A cg00817464 chr10:111662876 XPNPEP1 -0.6 -8.28 -0.42 3.03e-15 Biliary atresia; CRC cis rs2067615 0.579 rs7297592 chr12:107223969 G/T cg13491945 chr12:107078410 RFX4 0.34 5.73 0.3 2.3e-8 Heart rate; CRC cis rs713587 0.719 rs58048722 chr2:25187825 C/T cg04586622 chr2:25135609 ADCY3 0.35 5.96 0.31 6.35e-9 Body mass index in non-asthmatics; CRC cis rs2073499 1.000 rs76846888 chr3:50406058 C/T cg09545109 chr3:50388910 TUSC4;CYB561D2 0.64 5.75 0.3 2.02e-8 Schizophrenia; CRC cis rs55702914 0.625 rs59757315 chr2:198250213 T/C cg10820045 chr2:198174542 NA 0.4 7.04 0.36 1.15e-11 Major depression and alcohol dependence; CRC cis rs2120019 0.567 rs8025170 chr15:75170983 A/G cg17294928 chr15:75287854 SCAMP5 0.57 6.78 0.35 5.68e-11 Blood trace element (Zn levels); CRC cis rs10504229 1.000 rs72650885 chr8:58175131 G/A cg01721255 chr8:58191610 C8orf71 0.49 6.17 0.32 2e-9 Developmental language disorder (linguistic errors); CRC cis rs7119 0.637 rs2667775 chr15:77864802 T/G cg10437265 chr15:77819839 NA -0.54 -8.97 -0.44 2.24e-17 Type 2 diabetes; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg08265418 chr11:134123803 THYN1;ACAD8 0.41 6.68 0.35 1.05e-10 Liver disease severity in Alagille syndrome; CRC cis rs41005 0.967 rs41006 chr2:8109348 A/G cg03155496 chr2:8117019 LOC339788 0.4 7.15 0.37 5.73e-12 Response to anti-TNF therapy in rheumatoid arthritis; CRC cis rs1552244 0.882 rs67762674 chr3:10014485 C/T cg00166722 chr3:10149974 C3orf24 0.63 8.2 0.41 5.41e-15 Alzheimer's disease; CRC cis rs921968 0.643 rs500317 chr2:219432953 G/C cg02176678 chr2:219576539 TTLL4 0.47 7.86 0.4 5.36e-14 Mean corpuscular hemoglobin concentration; CRC cis rs8062405 0.755 rs62034358 chr16:28587597 G/T cg05139728 chr16:28306816 SBK1 -0.37 -6.05 -0.32 4.05e-9 Cognitive ability (multi-trait analysis);Cognitive ability; CRC cis rs950169 1.000 rs62026530 chr15:84775840 G/T cg11189052 chr15:85197271 WDR73 0.61 9.04 0.45 1.35e-17 Schizophrenia; CRC cis rs4654899 0.865 rs960564 chr1:21416435 G/T cg02927042 chr1:21476669 EIF4G3 -0.52 -8.18 -0.41 6.12e-15 Superior frontal gyrus grey matter volume; CRC cis rs8060686 0.920 rs58588228 chr16:67802010 C/T cg07125278 chr16:67683757 RLTPR -0.63 -6.85 -0.35 3.56e-11 HDL cholesterol;Metabolic syndrome; CRC cis rs2795502 0.882 rs2744095 chr10:43337949 A/T cg27426351 chr10:43362370 NA -0.59 -7.05 -0.36 1.04e-11 Blood protein levels; CRC cis rs7523050 0.730 rs35100394 chr1:109433989 C/G cg08274380 chr1:109419600 GPSM2 0.89 7.75 0.39 1.18e-13 Fat distribution (HIV); CRC cis rs853679 0.517 rs9368554 chr6:28082711 T/C cg23161317 chr6:28129485 ZNF389 0.54 6.56 0.34 2.12e-10 Depression; CRC cis rs6545883 0.965 rs9989775 chr2:61761774 A/G cg15711740 chr2:61764176 XPO1 -0.53 -7.32 -0.37 1.86e-12 Tuberculosis; CRC cis rs7259376 0.936 rs1865074 chr19:22554949 G/C cg02657401 chr19:22469223 NA -0.31 -6.77 -0.35 5.96e-11 Menopause (age at onset); CRC cis rs3087591 0.960 rs11870097 chr17:29448097 C/T cg24425628 chr17:29625626 OMG;NF1 0.88 16.42 0.67 1.1e-44 Hip circumference; CRC cis rs9902453 0.967 rs12602258 chr17:28317657 A/T cg26525008 chr17:28256777 EFCAB5;SSH2 0.59 8.89 0.44 4.22e-17 Coffee consumption (cups per day); CRC trans rs1656966 1.000 rs1656966 chr3:186466252 C/T cg04980793 chr14:35451984 SRP54 0.42 6.4 0.33 5.42e-10 Myopia (pathological); CRC trans rs875971 0.660 rs2191268 chr7:66110224 C/T cg09455096 chr2:61765470 XPO1 -0.4 -6.01 -0.31 4.86e-9 Aortic root size; CRC cis rs6460942 0.908 rs59410610 chr7:12282847 A/G cg20607287 chr7:12443886 VWDE -0.53 -5.69 -0.3 2.86e-8 Coronary artery disease; CRC cis rs9527 0.590 rs11191513 chr10:104772984 T/G cg04362960 chr10:104952993 NT5C2 0.59 8.42 0.42 1.18e-15 Arsenic metabolism; CRC cis rs68170813 0.559 rs76145119 chr7:107052368 C/T cg02696742 chr7:106810147 HBP1 -0.57 -5.9 -0.31 8.9e-9 Coronary artery disease; CRC cis rs9916302 0.706 rs4516267 chr17:37471482 G/T cg07936489 chr17:37558343 FBXL20 0.84 10.61 0.5 8.08e-23 Glomerular filtration rate (creatinine); CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg03641858 chr19:12777774 MORG1;MAN2B1 -0.4 -6.03 -0.32 4.42e-9 Myopia (pathological); CRC cis rs9649213 0.593 rs6465665 chr7:97934150 T/C cg00277769 chr7:97922759 BAIAP2L1 -0.61 -10.56 -0.5 1.2e-22 Prostate cancer (SNP x SNP interaction); CRC cis rs3857067 0.509 rs61069704 chr4:95091856 C/T cg11021082 chr4:95130006 SMARCAD1 -0.43 -6.15 -0.32 2.29e-9 QT interval; CRC cis rs875971 0.964 rs6978721 chr7:65883204 A/G cg11764359 chr7:65958608 NA 0.61 9.95 0.48 1.41e-20 Aortic root size; CRC cis rs4478858 0.647 rs4949380 chr1:31764160 A/G cg00250761 chr1:31883323 NA -0.44 -8.59 -0.43 3.52e-16 Alcohol dependence; CRC cis rs2013441 1.000 rs3850781 chr17:20181939 T/G cg13482628 chr17:19912719 NA -0.4 -6.17 -0.32 2e-9 Obesity-related traits; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg21244846 chr9:27529339 MOBKL2B 0.39 6.53 0.34 2.51e-10 Liver disease severity in Alagille syndrome; CRC cis rs728616 0.681 rs55899456 chr10:82050646 G/A cg11900509 chr10:81946545 ANXA11 -0.56 -6.12 -0.32 2.72e-9 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs7044106 0.718 rs10616 chr9:123363533 T/C cg09586646 chr9:123605570 PSMD5;LOC253039 0.56 8.13 0.41 8.87e-15 Hip circumference adjusted for BMI; CRC cis rs375066 0.623 rs1036246 chr19:44355264 C/T cg19542119 chr19:44331823 ZNF283 0.4 5.61 0.3 4.24e-8 Breast cancer; CRC cis rs877282 0.898 rs12354872 chr10:763362 G/A cg06581033 chr10:766294 NA -0.52 -5.78 -0.3 1.71e-8 Uric acid levels; CRC cis rs2952156 0.684 rs881844 chr17:37810218 C/G cg20243544 chr17:37824526 PNMT 0.53 8.49 0.42 7.38e-16 Asthma; CRC cis rs10479542 0.784 rs4701132 chr5:178985270 A/G cg00080972 chr5:178986291 RUFY1 -0.5 -10.11 -0.49 4.35e-21 Lung cancer; CRC cis rs1862618 0.802 rs7733041 chr5:56107377 A/C cg18230493 chr5:56204884 C5orf35 -0.69 -9.12 -0.45 7.49e-18 Initial pursuit acceleration; CRC cis rs7607369 0.714 rs2272190 chr2:219609995 G/C cg02176678 chr2:219576539 TTLL4 -0.39 -6.23 -0.32 1.41e-9 Red blood cell count;Amyotrophic lateral sclerosis; CRC cis rs10504229 1.000 rs73607863 chr8:58170178 A/G cg02725872 chr8:58115012 NA -0.38 -6.43 -0.33 4.44e-10 Developmental language disorder (linguistic errors); CRC trans rs2303319 0.504 rs56009150 chr2:162598582 T/C cg03757145 chr4:76555832 CDKL2 -0.65 -6.0 -0.31 5.07e-9 Cognitive function; CRC cis rs10760158 0.865 rs2239696 chr9:124029155 T/C cg14417974 chr9:124058376 GSN -0.34 -5.68 -0.3 3.01e-8 Pulse pressure; CRC cis rs1570884 0.536 rs1359541 chr13:50158939 A/G cg08779649 chr13:50194554 NA 0.42 8.7 0.43 1.61e-16 Sum basophil neutrophil counts;Sum neutrophil eosinophil counts;Neutrophil count;Myeloid white cell count;Granulocyte count; CRC cis rs73206853 0.841 rs57299791 chr12:110954021 G/A cg12870014 chr12:110450643 ANKRD13A 0.73 7.86 0.4 5.56e-14 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC cis rs2880765 0.835 rs4526974 chr15:86024284 C/T cg17133734 chr15:86042851 AKAP13 0.43 6.79 0.35 5.14e-11 Coronary artery disease; CRC cis rs9309711 0.666 rs6767 chr2:3483205 C/T cg15541040 chr2:3486749 NA -0.52 -8.37 -0.42 1.68e-15 Neurofibrillary tangles; CRC cis rs2732480 0.557 rs2732484 chr12:48737245 A/C cg24011408 chr12:48396354 COL2A1 0.47 6.36 0.33 6.59e-10 Hemoglobin concentration;Red blood cell count;Hematocrit; CRC cis rs1008375 0.966 rs758483 chr4:17703614 G/T cg16339924 chr4:17578868 LAP3 -0.5 -6.29 -0.33 9.82e-10 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs10751667 1.000 rs7395691 chr11:985006 T/C ch.11.42038R chr11:967971 AP2A2 0.62 9.97 0.48 1.26e-20 Alzheimer's disease (late onset); CRC cis rs8180040 0.966 rs13075233 chr3:47420627 T/C cg10298567 chr3:47292165 KIF9 -0.36 -5.92 -0.31 7.91e-9 Colorectal cancer; CRC cis rs17376456 0.877 rs10050465 chr5:93349963 C/A cg09848695 chr5:92956644 FAM172A;MIR2277 0.64 5.75 0.3 2.07e-8 Diabetic retinopathy; CRC cis rs1707322 0.827 rs12125508 chr1:46246010 A/G cg03146154 chr1:46216737 IPP 0.62 8.87 0.44 4.65e-17 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs2404602 0.684 rs8029283 chr15:76837140 A/G cg03037974 chr15:76606532 NA -0.49 -7.43 -0.38 9.25e-13 Blood metabolite levels; CRC cis rs514406 0.929 rs554301 chr1:53321948 A/T cg08859206 chr1:53392774 SCP2 0.42 6.66 0.34 1.12e-10 Monocyte count; CRC cis rs6456156 0.792 rs4710183 chr6:167514083 A/G cg07513332 chr6:167530253 CCR6 -0.36 -6.05 -0.32 4.05e-9 Primary biliary cholangitis; CRC cis rs2836754 1.000 rs2836754 chr21:40291740 C/T cg16734191 chr21:40194848 ETS2 0.32 5.8 0.3 1.56e-8 Crohn's disease;Body mass index; CRC cis rs79387448 0.745 rs9677607 chr2:103149520 A/T cg09003973 chr2:102972529 NA 0.73 8.14 0.41 8.53e-15 Gut microbiota (bacterial taxa); CRC cis rs172166 0.516 rs2021826 chr6:28132756 G/A cg02683197 chr6:28174875 NA 0.47 6.68 0.35 1.04e-10 Cardiac Troponin-T levels; CRC cis rs2797160 0.651 rs1269176 chr6:126029682 A/T cg05901451 chr6:126070800 HEY2 -0.49 -7.87 -0.4 5.02e-14 Endometrial cancer; CRC cis rs2302190 0.882 rs11658998 chr17:56655786 T/G cg25885038 chr17:56607967 SEPT4 -0.5 -7.59 -0.39 3.36e-13 Vitamin D levels; CRC cis rs2976388 0.525 rs2016749 chr8:143836118 G/A cg20041105 chr8:143859282 LYNX1 -0.58 -10.49 -0.5 2.07e-22 Urinary tract infection frequency; CRC cis rs2980439 0.870 rs2945230 chr8:8109936 A/G cg08975724 chr8:8085496 FLJ10661 0.43 6.62 0.34 1.48e-10 Neuroticism; CRC cis rs873946 0.586 rs12774727 chr10:134569910 T/C cg18305652 chr10:134549665 INPP5A 0.49 6.27 0.33 1.11e-9 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CRC cis rs3018066 0.738 rs76654812 chr4:106944699 C/T cg01869342 chr4:106983673 TBCK 0.45 6.06 0.32 3.66e-9 Cancer; CRC cis rs9463078 0.585 rs10456552 chr6:45313952 G/A cg25276700 chr6:44698697 NA 0.25 5.98 0.31 5.75e-9 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; CRC cis rs514406 0.929 rs562178 chr1:53319562 T/C cg08859206 chr1:53392774 SCP2 -0.42 -6.77 -0.35 6.08e-11 Monocyte count; CRC cis rs6911131 0.504 rs79489282 chr6:143906265 G/A cg25407410 chr6:143891975 LOC285740 0.71 5.74 0.3 2.21e-8 Response to paliperidone in schizophrenia (positive Marder score); CRC cis rs6951245 0.529 rs76001997 chr7:1152615 C/T cg26224354 chr7:1096374 C7orf50;GPR146 -0.57 -7.71 -0.39 1.48e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg24971181 chr8:25316395 CDCA2;KCTD9 0.44 6.51 0.34 2.81e-10 Intelligence (multi-trait analysis); CRC cis rs7223966 1.000 rs2854223 chr17:61939014 A/G cg23090583 chr17:61904693 PSMC5;FTSJ3 0.48 6.14 0.32 2.41e-9 Hip circumference adjusted for BMI;Body mass index; CRC cis rs7208859 0.673 rs11654331 chr17:29165017 A/G cg13385521 chr17:29058706 SUZ12P 0.65 7.7 0.39 1.64e-13 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs2404602 0.716 rs56351018 chr15:76824591 T/C cg22467129 chr15:76604101 ETFA -0.45 -7.49 -0.38 6.33e-13 Blood metabolite levels; CRC cis rs4728302 0.869 rs6978170 chr7:133603838 C/T cg03336402 chr7:133662267 EXOC4 -0.45 -6.52 -0.34 2.61e-10 Intelligence;Intelligence (multi-trait analysis); CRC trans rs3791556 1.000 rs2411429 chr2:240113928 A/G cg00066750 chr6:126080132 HEY2 0.58 6.16 0.32 2.11e-9 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC trans rs916888 0.610 rs142167 chr17:44795234 C/T cg22433210 chr17:43662623 NA -0.62 -7.39 -0.38 1.24e-12 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC trans rs3858526 0.883 rs4758183 chr11:5925178 C/G cg01505111 chr6:125621795 HDDC2 0.38 5.98 0.31 5.69e-9 DNA methylation (variation); CRC cis rs7959452 0.640 rs12370042 chr12:69692420 C/G cg22834771 chr12:69754056 YEATS4 -0.41 -5.81 -0.31 1.48e-8 Blood protein levels; CRC cis rs798554 0.718 rs1636247 chr7:2881917 A/G cg04166393 chr7:2884313 GNA12 0.58 7.72 0.39 1.44e-13 Height; CRC cis rs9463078 0.727 rs9463054 chr6:44917197 T/C cg25276700 chr6:44698697 NA -0.27 -6.69 -0.35 9.48e-11 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; CRC cis rs4711336 1.000 rs764754 chr6:33658310 C/T cg14003231 chr6:33640908 ITPR3 0.51 8.22 0.41 4.71e-15 Height; CRC trans rs7937682 0.575 rs12808601 chr11:111776066 G/A cg18187862 chr3:45730750 SACM1L -0.43 -5.99 -0.31 5.56e-9 Primary sclerosing cholangitis; CRC cis rs873946 0.648 rs3793673 chr10:134547732 A/C cg06453172 chr10:134556979 INPP5A -0.69 -8.7 -0.43 1.65e-16 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CRC cis rs4588572 0.643 rs6453396 chr5:77785387 T/C cg11446398 chr5:77624930 NA 0.45 5.99 0.31 5.64e-9 Triglycerides; CRC cis rs2732480 0.557 rs2409004 chr12:48721451 T/C cg24011408 chr12:48396354 COL2A1 0.45 6.19 0.32 1.84e-9 Hemoglobin concentration;Red blood cell count;Hematocrit; CRC cis rs394563 0.591 rs237016 chr6:149744859 T/C cg03678062 chr6:149772716 ZC3H12D -0.34 -6.19 -0.32 1.83e-9 Dupuytren's disease; CRC cis rs7772486 0.902 rs1331643 chr6:146398873 T/A cg23711669 chr6:146136114 FBXO30 0.6 10.31 0.49 9.09e-22 Lobe attachment (rater-scored or self-reported); CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg00857557 chr6:42982050 MEA1;KLHDC3 -0.41 -6.26 -0.33 1.2e-9 Myopia (pathological); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg07380405 chr12:7126460 LPCAT3 0.45 6.35 0.33 7.03e-10 Response to antipsychotic treatment; CRC cis rs3617 0.572 rs2256332 chr3:52855865 A/G cg18099408 chr3:52552593 STAB1 0.34 5.91 0.31 8.56e-9 Red blood cell count;Autism spectrum disorder or schizophrenia; CRC cis rs2204008 0.658 rs11495742 chr12:38395688 C/A cg26384229 chr12:38710491 ALG10B 0.7 9.13 0.45 6.88e-18 Bladder cancer; CRC cis rs910316 0.967 rs8013444 chr14:75661981 A/G cg08847533 chr14:75593920 NEK9 -0.85 -14.89 -0.63 1.04e-38 Height; CRC cis rs995000 0.965 rs1168023 chr1:63006595 A/T cg19896129 chr1:63156450 NA -0.45 -7.04 -0.36 1.15e-11 Triglyceride levels; CRC cis rs12612619 0.732 rs4665366 chr2:27212596 G/A cg00617064 chr2:27272375 NA 0.34 5.61 0.3 4.23e-8 Venous thromboembolism adjusted for sickle cell variant rs77121243-T; CRC cis rs8060686 0.545 rs12597573 chr16:68167521 A/C cg26727032 chr16:67993705 SLC12A4 0.6 6.55 0.34 2.2e-10 HDL cholesterol;Metabolic syndrome; CRC cis rs10751667 0.666 rs10902249 chr11:958566 C/T cg01483505 chr11:975446 AP2A2 -0.44 -7.29 -0.37 2.37e-12 Alzheimer's disease (late onset); CRC cis rs9361491 0.657 rs13198615 chr6:79430552 A/G cg05283184 chr6:79620031 NA -0.37 -5.73 -0.3 2.31e-8 Intelligence (multi-trait analysis); CRC cis rs12692738 0.526 rs355837 chr2:165619091 A/G cg03182029 chr2:165697222 COBLL1 0.5 6.02 0.31 4.71e-9 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);Waist-to-hip ratio adjusted for BMI in non-smokers;Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction);Waist-to-hip ratio adjusted for body mass index; CRC cis rs9527 0.590 rs2066322 chr10:104909339 T/G cg04362960 chr10:104952993 NT5C2 0.6 8.36 0.42 1.74e-15 Arsenic metabolism; CRC cis rs11190604 1.000 rs11190597 chr10:102293676 A/T cg16342193 chr10:102329863 NA -0.36 -5.91 -0.31 8.64e-9 Palmitoleic acid (16:1n-7) levels; CRC cis rs10256972 0.621 rs2280725 chr7:1087426 G/T cg03923535 chr7:1197113 ZFAND2A 0.55 8.03 0.4 1.74e-14 Longevity;Endometriosis; CRC cis rs8077889 0.672 rs1230397 chr17:41844689 A/G cg25876840 chr17:41920477 NA 0.41 6.54 0.34 2.3e-10 Triglycerides; CRC cis rs12472274 0.941 rs11677230 chr2:239092054 T/C cg17459225 chr2:239074497 NA 0.84 14.47 0.62 4.76e-37 Phospholipid levels (plasma); CRC cis rs2243480 0.901 rs73142137 chr7:65343442 A/T cg12463550 chr7:65579703 CRCP 0.71 6.53 0.34 2.52e-10 Diabetic kidney disease; CRC cis rs11212617 0.901 rs594153 chr11:108131646 T/G cg01991180 chr11:108092276 ATM;NPAT 0.4 5.77 0.3 1.79e-8 Response to metformin in type 2 diabetes (glycemic); CRC cis rs7811142 1.000 rs73161762 chr7:100014846 C/T cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.99 12.99 0.58 2.05e-31 Platelet count; CRC cis rs7917772 0.565 rs61869210 chr10:104437175 A/C cg04362960 chr10:104952993 NT5C2 -0.46 -5.68 -0.3 3e-8 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC cis rs1348850 0.958 rs4893965 chr2:178463852 G/T cg02961200 chr2:178257176 LOC100130691;AGPS 0.52 7.53 0.38 4.83e-13 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs9470366 0.772 rs9918353 chr6:36622677 A/C cg08179530 chr6:36648295 CDKN1A 0.49 5.8 0.3 1.59e-8 QRS duration; CRC cis rs1552244 0.882 rs55962400 chr3:10044457 C/T cg10729496 chr3:10149963 C3orf24 0.52 6.38 0.33 6.14e-10 Alzheimer's disease; CRC cis rs344364 0.511 rs337286 chr16:1965719 C/T cg03013636 chr16:1946785 NA 0.55 6.55 0.34 2.25e-10 Glomerular filtration rate in chronic kidney disease; CRC cis rs2549003 0.966 rs10065633 chr5:131816716 T/C cg21138405 chr5:131827807 IRF1 0.57 11.33 0.53 2.39e-25 Asthma (sex interaction); CRC cis rs490234 0.588 rs35278449 chr9:128172963 C/G cg14078157 chr9:128172775 NA -0.42 -6.8 -0.35 4.99e-11 Mean arterial pressure; CRC cis rs35146811 0.735 rs858506 chr7:99820050 T/C cg00553149 chr7:99775558 STAG3;GPC2 -0.25 -5.74 -0.3 2.16e-8 Coronary artery disease; CRC cis rs1656402 0.953 rs1550099 chr2:233428147 A/G cg03852847 chr2:233439513 NA 0.42 7.27 0.37 2.71e-12 Non-small cell lung cancer (survival); CRC cis rs2180341 0.961 rs9375501 chr6:127652539 C/T cg27446573 chr6:127587934 RNF146 0.98 14.42 0.62 6.85e-37 Breast cancer; CRC cis rs7618501 0.699 rs2681780 chr3:49897830 C/T cg05623727 chr3:50126028 RBM5 0.46 7.32 0.37 1.95e-12 Intelligence (multi-trait analysis); CRC cis rs2836950 0.565 rs7278297 chr21:40625752 A/C cg17971929 chr21:40555470 PSMG1 -0.53 -7.45 -0.38 8.18e-13 Menarche (age at onset); CRC cis rs7781266 1.000 rs7781266 chr7:133505101 G/T cg03336402 chr7:133662267 EXOC4 0.58 7.86 0.4 5.6e-14 Educational attainment (college completion); CRC cis rs6793245 0.810 rs1805126 chr3:38592406 C/T cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.52 7.66 0.39 2.09e-13 QT interval; CRC cis rs6502050 0.805 rs7406137 chr17:80084465 T/C cg25804541 chr17:80189381 SLC16A3 0.31 5.84 0.31 1.25e-8 Life satisfaction; CRC cis rs747650 0.926 rs10838659 chr11:47148210 C/T cg03339077 chr11:47165057 C11orf49 0.5 7.3 0.37 2.22e-12 Acne (severe); CRC cis rs13191362 1.000 rs67046187 chr6:163068532 C/A cg23758597 chr6:163146217 PARK2 -0.65 -6.58 -0.34 1.91e-10 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs9868809 0.881 rs6773261 chr3:48675064 A/G cg00383909 chr3:49044727 WDR6 0.69 7.15 0.37 5.49e-12 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; CRC trans rs2243480 1.000 rs937108 chr7:65428452 G/A cg10756647 chr7:56101905 PSPH 0.73 8.1 0.41 1.11e-14 Diabetic kidney disease; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg06159435 chr11:118966351 H2AFX 0.43 7.09 0.36 8.33e-12 Liver disease severity in Alagille syndrome; CRC cis rs4925325 0.956 rs1776263 chr20:60515820 A/G cg12751644 chr20:60527061 NA -0.5 -7.5 -0.38 6.16e-13 Obesity-related traits; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg26994227 chr5:130971071 RAPGEF6 0.39 6.19 0.32 1.78e-9 Liver disease severity in Alagille syndrome; CRC cis rs11190604 0.943 rs11190581 chr10:102243387 T/G cg16342193 chr10:102329863 NA -0.36 -5.93 -0.31 7.49e-9 Palmitoleic acid (16:1n-7) levels; CRC cis rs2153535 0.541 rs9505456 chr6:8479001 T/C cg21535247 chr6:8435926 SLC35B3 0.5 7.54 0.38 4.72e-13 Motion sickness; CRC cis rs7618915 0.547 rs3774365 chr3:52642487 T/C cg07507251 chr3:52567010 NT5DC2 0.42 6.07 0.32 3.43e-9 Bipolar disorder; CRC cis rs875971 0.862 rs10950043 chr7:65988610 T/C cg18876405 chr7:65276391 NA 0.52 8.38 0.42 1.6e-15 Aortic root size; CRC cis rs1799949 1.000 rs12936816 chr17:41301709 C/T cg19454999 chr17:41278357 BRCA1;NBR2 0.55 8.65 0.43 2.28e-16 Menopause (age at onset); CRC cis rs921968 0.643 rs659185 chr2:219335935 C/T cg02176678 chr2:219576539 TTLL4 0.49 8.05 0.41 1.58e-14 Mean corpuscular hemoglobin concentration; CRC cis rs11719291 0.667 rs9877542 chr3:48748545 C/T cg07636037 chr3:49044803 WDR6 -0.68 -6.65 -0.34 1.19e-10 Cognitive function; CRC cis rs815815 0.608 rs815809 chr2:47380203 T/C cg27223769 chr2:47403360 CALM2 -0.58 -7.55 -0.38 4.41e-13 Dialysis-related mortality; CRC cis rs6066835 1.000 rs6066837 chr20:47357337 A/C cg18078177 chr20:47281410 PREX1 0.65 6.05 0.32 4.01e-9 Multiple myeloma; CRC cis rs7618915 0.508 rs7628578 chr3:52628321 A/T cg11645453 chr3:52864694 ITIH4 0.37 6.68 0.35 9.97e-11 Bipolar disorder; CRC cis rs4285028 0.699 rs2689285 chr3:121586486 G/A cg20356878 chr3:121714668 ILDR1 0.5 6.9 0.36 2.69e-11 Multiple sclerosis; CRC cis rs72781680 0.716 rs2551325 chr2:23979729 C/T cg08917208 chr2:24149416 ATAD2B 0.56 6.42 0.33 4.76e-10 Lymphocyte counts; CRC cis rs9381040 0.655 rs2268190 chr6:41030226 C/T cg03644281 chr6:41068752 NFYA;LOC221442 -0.45 -6.51 -0.34 2.88e-10 Alzheimer's disease (late onset); CRC cis rs13191362 1.000 rs73035025 chr6:163000988 T/C cg21926612 chr6:163149169 PACRG;PARK2 0.8 11.25 0.53 4.59e-25 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs2075371 1.000 rs2058976 chr7:133981379 G/T cg20476274 chr7:133979776 SLC35B4 0.83 15.23 0.64 5.35e-40 Mean platelet volume; CRC cis rs4975709 0.569 rs1684965 chr5:1865248 A/G cg12288994 chr5:1860383 NA 0.38 6.66 0.34 1.12e-10 Cardiovascular disease risk factors; CRC cis rs7959452 0.640 rs4274230 chr12:69700772 T/G cg20891283 chr12:69753455 YEATS4 0.79 13.19 0.59 3.55e-32 Blood protein levels; CRC cis rs939658 0.805 rs4778924 chr15:79443363 T/C cg17916960 chr15:79447300 NA -0.43 -6.87 -0.35 3.18e-11 Refractive error; CRC trans rs7618501 0.603 rs72942333 chr3:49986118 T/C cg21659725 chr3:3221576 CRBN 0.6 9.45 0.46 6.65e-19 Intelligence (multi-trait analysis); CRC cis rs9322817 0.691 rs4142531 chr6:105324811 G/A cg02098413 chr6:105308735 HACE1 0.43 8.49 0.42 7.27e-16 Thyroid stimulating hormone; CRC cis rs7680126 0.596 rs4637402 chr4:10045430 C/T cg00071950 chr4:10020882 SLC2A9 0.56 7.96 0.4 2.87e-14 Urate levels in lean individuals;Urate levels in overweight individuals;Urate levels in obese individuals; CRC cis rs9469913 0.542 rs75398113 chr6:34728071 G/C cg14254433 chr6:34482411 PACSIN1 -0.68 -5.93 -0.31 7.51e-9 Body mass index (joint analysis main effects and physical activity interaction);Body mass index;Body mass index in physically active individuals; CRC cis rs11711311 1.000 rs9830975 chr3:113486019 A/G cg15478005 chr3:113465772 ATP6V1A;NAA50 0.45 6.3 0.33 9.55e-10 IgG glycosylation; CRC cis rs9322817 0.691 rs7769270 chr6:105230729 C/A cg02098413 chr6:105308735 HACE1 -0.44 -8.55 -0.43 4.67e-16 Thyroid stimulating hormone; CRC trans rs67981189 0.679 rs221901 chr14:71602226 C/T cg06081482 chr11:108093084 ATM;NPAT -0.44 -6.01 -0.31 4.83e-9 Schizophrenia; CRC cis rs9858542 0.953 rs4625 chr3:49572140 A/G cg03060546 chr3:49711283 APEH -0.47 -6.5 -0.34 2.9e-10 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs1865760 0.566 rs7772312 chr6:26049616 G/C cg18357526 chr6:26021779 HIST1H4A 0.41 5.8 0.3 1.54e-8 Height; CRC cis rs11155671 0.530 rs6557133 chr6:150195384 G/T cg07701084 chr6:150067640 NUP43 0.44 6.31 0.33 8.79e-10 Testicular germ cell tumor; CRC trans rs12599106 0.792 rs12597352 chr16:34638507 A/T cg05064044 chr6:292385 DUSP22 -0.57 -8.01 -0.4 2.01e-14 Menopause (age at onset); CRC cis rs4523957 0.893 rs11078018 chr17:2162119 A/G cg16513277 chr17:2031491 SMG6 -0.53 -8.76 -0.43 1.07e-16 Autism spectrum disorder or schizophrenia;Schizophrenia; CRC cis rs2204008 0.626 rs11520260 chr12:38330092 C/T cg13010199 chr12:38710504 ALG10B 0.46 6.1 0.32 3.04e-9 Bladder cancer; CRC cis rs10193935 1.000 rs13411405 chr2:42413811 C/A cg27598129 chr2:42591480 NA -0.71 -8.18 -0.41 6.37e-15 Colonoscopy-negative controls vs population controls; CRC cis rs7914558 0.752 rs7896519 chr10:104866863 C/T cg04362960 chr10:104952993 NT5C2 0.63 8.98 0.44 2.13e-17 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs9611565 0.512 rs9607841 chr22:42186838 G/A cg17554472 chr22:41940697 POLR3H -0.57 -5.83 -0.31 1.36e-8 Vitiligo; CRC cis rs1107366 1.000 rs1107366 chr3:125904165 A/G cg20988073 chr3:125900093 ALDH1L1 -0.34 -5.75 -0.3 1.99e-8 Metabolite levels; CRC cis rs909002 0.800 rs11589306 chr1:32082822 C/G cg01639898 chr1:32083012 HCRTR1 0.29 5.93 0.31 7.58e-9 Intelligence (multi-trait analysis); CRC cis rs10751667 1.000 rs11246359 chr11:967943 T/C cg01483505 chr11:975446 AP2A2 0.41 6.23 0.33 1.39e-9 Alzheimer's disease (late onset); CRC cis rs10540 1.000 rs35068485 chr11:466032 A/T cg19913688 chr11:428466 ANO9 -0.72 -7.58 -0.39 3.58e-13 Body mass index; CRC cis rs7605827 0.930 rs2287276 chr2:15660254 A/G cg19274914 chr2:15703543 NA 0.39 5.89 0.31 9.8e-9 Educational attainment (years of education); CRC cis rs796364 0.806 rs12619136 chr2:200910347 C/A cg25936922 chr2:200820526 C2orf60;C2orf47 -0.7 -6.57 -0.34 2.02e-10 Schizophrenia; CRC cis rs5769765 0.862 rs9616386 chr22:50313179 G/A cg02269571 chr22:50332266 NA -0.61 -7.92 -0.4 3.64e-14 Schizophrenia; CRC cis rs2836950 0.501 rs2836985 chr21:40701169 A/G cg17971929 chr21:40555470 PSMG1 -0.51 -7.21 -0.37 3.76e-12 Menarche (age at onset); CRC cis rs6831352 0.819 rs1230158 chr4:99990186 T/C cg12011299 chr4:100065546 ADH4 0.47 9.46 0.46 5.91e-19 Alcohol dependence; CRC cis rs11098499 0.754 rs938056 chr4:120237453 C/T cg09307838 chr4:120376055 NA 0.61 9.58 0.47 2.37e-19 Corneal astigmatism; CRC cis rs5750830 0.649 rs5750811 chr22:39793066 G/T cg24399712 chr22:39784796 NA 0.51 9.66 0.47 1.36e-19 Intelligence (multi-trait analysis); CRC cis rs62367758 0.683 rs316413 chr5:43094029 A/G cg09164108 chr5:43007320 NA -0.47 -5.76 -0.3 1.96e-8 Facial morphology (factor 8, orbital inclination due to vertical and horizontal position of exocanthion); CRC cis rs929354 0.935 rs1182392 chr7:157036200 C/T cg17757837 chr7:157058334 UBE3C -0.77 -13.87 -0.61 9.19e-35 Body mass index; CRC cis rs4969178 1.000 rs4969178 chr17:76388202 C/T cg05887092 chr17:76393375 PGS1 -0.54 -10.03 -0.48 7.8e-21 HDL cholesterol levels; CRC cis rs1799949 1.000 rs4793231 chr17:41427469 A/G cg05368731 chr17:41323189 NBR1 0.64 9.2 0.45 4.26e-18 Menopause (age at onset); CRC cis rs10207060 1.000 rs10207060 chr2:240687289 A/C cg07506560 chr2:240697449 NA 0.43 7.04 0.36 1.1e-11 Obesity-related traits; CRC cis rs13418410 0.539 rs35866672 chr2:33842174 G/A cg04131969 chr2:33951647 MYADML -0.68 -9.98 -0.48 1.14e-20 Non-response to antidepressants and depression; CRC cis rs2303745 0.589 rs1864116 chr19:17393015 C/T cg27101125 chr19:17392770 ANKLE1 -0.33 -5.75 -0.3 1.99e-8 Systemic lupus erythematosus; CRC cis rs10782582 0.609 rs76260657 chr1:76338017 C/T cg03433033 chr1:76189801 ACADM -0.41 -5.85 -0.31 1.19e-8 Daytime sleep phenotypes; CRC cis rs9611565 0.559 rs6002408 chr22:41967870 C/T cg03806693 chr22:41940476 POLR3H -0.87 -10.59 -0.5 9.4e-23 Vitiligo; CRC cis rs7212938 0.509 rs3893044 chr17:38103016 C/T cg26162295 chr17:38119207 GSDMA 0.39 6.95 0.36 1.99e-11 Asthma and hay fever; CRC cis rs9467711 0.606 rs9379851 chr6:26354780 A/C cg14345882 chr6:26364793 BTN3A2 0.65 5.83 0.31 1.36e-8 Autism spectrum disorder or schizophrenia; CRC cis rs4648845 0.777 rs2477686 chr1:2392648 C/G cg07700843 chr1:2391317 NA -0.49 -8.39 -0.42 1.45e-15 Schizophrenia; CRC cis rs6860806 0.661 rs334902 chr5:131586559 C/G cg12564285 chr5:131593104 PDLIM4 0.5 9.45 0.46 6.35e-19 Breast cancer; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg12081917 chr17:39804985 NA 0.51 7.32 0.37 1.9e-12 Response to antipsychotic treatment; CRC cis rs12545109 0.765 rs2610047 chr8:57412106 T/C cg09654669 chr8:57350985 NA -0.46 -7.45 -0.38 8.25e-13 Obesity-related traits; CRC trans rs10504229 0.953 rs66509078 chr8:58174734 G/C cg04077850 chr5:125800366 GRAMD3 0.37 6.27 0.33 1.15e-9 Developmental language disorder (linguistic errors); CRC cis rs1707322 0.682 rs28508523 chr1:46189625 G/A cg06784218 chr1:46089804 CCDC17 0.58 10.52 0.5 1.69e-22 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC trans rs6833159 0.527 rs10939231 chr4:28829372 A/T cg14213021 chr10:71930531 SAR1A -0.43 -6.39 -0.33 5.72e-10 Underweight status; CRC trans rs11098499 0.863 rs11098531 chr4:120465001 G/A cg25214090 chr10:38739885 LOC399744 0.65 10.43 0.5 3.37e-22 Corneal astigmatism; CRC cis rs9902453 0.845 rs3102556 chr17:28042542 C/T cg26525008 chr17:28256777 EFCAB5;SSH2 0.58 8.73 0.43 1.3e-16 Coffee consumption (cups per day); CRC cis rs2976388 0.609 rs1469811 chr8:143787999 C/T cg15511327 chr8:143859410 LYNX1 0.41 7.24 0.37 3.28e-12 Urinary tract infection frequency; CRC cis rs7580658 0.724 rs6712551 chr2:127998485 G/A cg09760422 chr2:128146352 NA -0.36 -7.1 -0.36 7.91e-12 Protein C levels; CRC cis rs6921919 0.697 rs6942030 chr6:28315958 A/T cg06470822 chr6:28175283 NA 0.48 6.52 0.34 2.66e-10 Autism spectrum disorder or schizophrenia; CRC cis rs2404602 0.692 rs3816266 chr15:76993835 T/G cg03037974 chr15:76606532 NA 0.69 12.13 0.56 3.19e-28 Blood metabolite levels; CRC cis rs4253772 0.591 rs6007795 chr22:46686792 C/G cg24881330 chr22:46731750 TRMU 0.68 8.73 0.43 1.29e-16 LDL cholesterol;Cholesterol, total; CRC cis rs3617 0.625 rs6769789 chr3:52874446 C/T cg18099408 chr3:52552593 STAB1 0.35 6.04 0.32 4.15e-9 Red blood cell count;Autism spectrum disorder or schizophrenia; CRC trans rs10982213 0.830 rs2274163 chr9:117188714 C/T cg00052422 chr3:41240987 CTNNB1 0.39 6.0 0.31 5.17e-9 Interleukin-6 levels; CRC cis rs11098499 0.954 rs10017371 chr4:120293776 A/G cg09307838 chr4:120376055 NA 0.69 10.65 0.51 6.17e-23 Corneal astigmatism; CRC trans rs3960554 0.932 rs11971220 chr7:75842792 C/T cg19862616 chr7:65841803 NCRNA00174 0.71 7.9 0.4 4.14e-14 Eotaxin levels; CRC cis rs1552244 1.000 rs9827740 chr3:10120531 T/C cg13047869 chr3:10149882 C3orf24 0.53 7.53 0.38 5e-13 Alzheimer's disease; CRC trans rs7615952 0.736 rs13063122 chr3:125643860 G/A cg00769240 chr8:12517080 NA -0.57 -6.69 -0.35 9.48e-11 Blood pressure (smoking interaction); CRC cis rs4780401 0.755 rs8191297 chr16:11766986 T/C cg01061890 chr16:11836724 TXNDC11 -0.42 -5.73 -0.3 2.28e-8 Rheumatoid arthritis; CRC cis rs12913538 0.962 rs4774442 chr15:62897853 G/A cg09983546 chr15:62884068 NA 0.57 9.09 0.45 9.56e-18 Sleep depth; CRC cis rs9322193 0.923 rs9480031 chr6:150080011 A/C cg13206674 chr6:150067644 NUP43 0.68 10.28 0.49 1.08e-21 Lung cancer; CRC cis rs898097 0.812 rs7406011 chr17:80829980 C/T cg15664640 chr17:80829946 TBCD -0.71 -11.94 -0.55 1.47e-27 Breast cancer; CRC cis rs1538970 0.669 rs3219476 chr1:45802670 A/C cg05343316 chr1:45956843 TESK2 -0.42 -6.11 -0.32 2.88e-9 Platelet count; CRC cis rs738322 0.574 rs28653361 chr22:38570700 C/A cg25457927 chr22:38595422 NA -0.31 -5.87 -0.31 1.05e-8 Cutaneous nevi; CRC cis rs1357245 0.692 rs34978733 chr3:27204567 T/C cg02860705 chr3:27208620 NA -0.39 -5.84 -0.31 1.25e-8 Breast cancer; CRC cis rs950169 0.614 rs12903883 chr15:84680553 A/G cg17507749 chr15:85114479 UBE2QP1 0.66 8.94 0.44 2.82e-17 Schizophrenia; CRC cis rs1153858 1.000 rs9783731 chr15:45642884 C/T cg14582100 chr15:45693742 SPATA5L1 -0.3 -6.28 -0.33 1.1e-9 Homoarginine levels; CRC cis rs2180341 0.920 rs6906717 chr6:127596782 C/A cg27446573 chr6:127587934 RNF146 0.99 14.76 0.63 3.48e-38 Breast cancer; CRC cis rs9322193 0.923 rs55849538 chr6:149956466 T/C cg05861140 chr6:150128134 PCMT1 -0.38 -5.85 -0.31 1.17e-8 Lung cancer; CRC trans rs2727020 0.729 rs1164685 chr11:49293660 G/A cg11707556 chr5:10655725 ANKRD33B 0.34 6.31 0.33 9.24e-10 Coronary artery disease; CRC cis rs4713118 0.513 rs149959 chr6:28013854 T/C cg12172441 chr6:28176163 NA 0.49 6.66 0.34 1.16e-10 Parkinson's disease; CRC cis rs6912958 0.559 rs369674 chr6:88043402 C/G cg04972856 chr6:88032051 C6orf162;GJB7 -0.32 -6.07 -0.32 3.53e-9 Monocyte percentage of white cells; CRC cis rs6860806 0.661 rs2171247 chr5:131580234 G/T cg02033258 chr5:131593261 PDLIM4 0.38 7.19 0.37 4.3e-12 Breast cancer; CRC cis rs1552244 0.832 rs115415687 chr3:10195704 C/T cg13047869 chr3:10149882 C3orf24 0.56 6.66 0.34 1.15e-10 Alzheimer's disease; CRC cis rs877282 0.853 rs7083589 chr10:754494 G/A cg17470449 chr10:769945 NA 0.61 7.96 0.4 2.78e-14 Uric acid levels; CRC cis rs875971 0.545 rs7787063 chr7:65628999 G/A cg05627663 chr7:65219948 SNORA22;CCT6P1 0.6 7.67 0.39 1.92e-13 Aortic root size; CRC cis rs4713118 0.738 rs200465 chr6:27757654 T/A cg21251018 chr6:28226885 NKAPL 0.44 6.32 0.33 8.51e-10 Parkinson's disease; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg07949612 chr2:69664562 NFU1 0.41 6.02 0.31 4.73e-9 Intelligence (multi-trait analysis); CRC cis rs4555082 0.834 rs2816607 chr14:105718385 A/T cg06808227 chr14:105710500 BRF1 -0.59 -8.31 -0.42 2.55e-15 Mean platelet volume;Platelet distribution width; CRC cis rs2295359 0.892 rs12401432 chr1:67656931 C/G cg03340356 chr1:67600835 NA 0.3 6.77 0.35 5.77e-11 Psoriasis; CRC cis rs6565180 0.888 rs12447833 chr16:30390314 T/C cg01392867 chr16:30410429 ZNF48 0.38 6.09 0.32 3.21e-9 Tonsillectomy; CRC cis rs1568889 0.887 rs2062269 chr11:28116537 C/T cg06544937 chr11:28130018 METT5D1;KIF18A 0.9 15.13 0.64 1.23e-39 Bipolar disorder; CRC cis rs6061231 1.000 rs67941642 chr20:60958108 C/T cg22601191 chr20:60968625 CABLES2 0.45 7.42 0.38 9.94e-13 Colorectal cancer; CRC cis rs71403859 0.614 rs12149533 chr16:71801946 C/T cg08717414 chr16:71523259 ZNF19 -1.07 -9.57 -0.47 2.57e-19 Post bronchodilator FEV1; CRC cis rs995000 0.931 rs11207970 chr1:62915473 C/T cg19896129 chr1:63156450 NA 0.39 5.7 0.3 2.62e-8 Triglyceride levels; CRC cis rs16867321 0.950 rs9677293 chr2:181499459 C/G cg23363182 chr2:181467187 NA -0.51 -6.65 -0.34 1.21e-10 Obesity; CRC cis rs11601602 0.576 rs12576396 chr11:28555952 C/T cg06544937 chr11:28130018 METT5D1;KIF18A 0.62 8.39 0.42 1.45e-15 Obesity-related traits; CRC cis rs853679 0.517 rs9380050 chr6:28048538 A/G cg12273811 chr6:28175739 NA 0.69 8.83 0.44 6.17e-17 Depression; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg20470467 chr16:30886130 NA 0.47 5.96 0.31 6.55e-9 Thyroid stimulating hormone; CRC cis rs9611565 0.559 rs13056262 chr22:42081921 A/G cg03806693 chr22:41940476 POLR3H 1.05 13.07 0.58 1.02e-31 Vitiligo; CRC cis rs9462846 0.691 rs7744454 chr6:42914041 C/G cg21280719 chr6:42927975 GNMT -0.34 -6.26 -0.33 1.22e-9 Blood protein levels; CRC cis rs8067545 0.563 rs3850780 chr17:20181902 A/C cg13482628 chr17:19912719 NA -0.48 -7.64 -0.39 2.43e-13 Schizophrenia; CRC cis rs7917772 0.503 rs7068535 chr10:104349127 C/T cg11453585 chr10:104263688 ACTR1A;SUFU 0.88 16.12 0.66 1.64e-43 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC cis rs1448094 0.791 rs61929395 chr12:86331584 A/T cg25456477 chr12:86230367 RASSF9 0.34 5.77 0.3 1.82e-8 Major depressive disorder; CRC cis rs7959452 0.535 rs10878953 chr12:69674187 A/G cg20891283 chr12:69753455 YEATS4 0.76 13.05 0.58 1.17e-31 Blood protein levels; CRC cis rs3106136 0.967 rs72665658 chr4:95144761 C/T cg11021082 chr4:95130006 SMARCAD1 -0.46 -7.18 -0.37 4.6e-12 Capecitabine sensitivity; CRC cis rs17345786 0.906 rs11708616 chr3:101231731 C/T cg11279151 chr3:101281821 RG9MTD1 -0.66 -8.34 -0.42 2.08e-15 Colonoscopy-negative controls vs population controls; CRC cis rs875971 0.964 rs6945032 chr7:65922486 C/T cg11764359 chr7:65958608 NA 0.62 9.91 0.48 1.96e-20 Aortic root size; CRC cis rs1670533 0.932 rs6599276 chr4:1056827 T/C cg27284194 chr4:1044797 NA 0.5 6.2 0.32 1.66e-9 Recombination rate (females); CRC cis rs4665809 0.590 rs4665313 chr2:26415897 A/G cg26119090 chr2:26468346 HADHA;HADHB -1.04 -15.12 -0.64 1.37e-39 Gut microbiome composition (summer); CRC trans rs7647973 0.626 rs4855849 chr3:49653378 A/G cg21665057 chr3:196295764 WDR53;FBXO45 -0.67 -7.37 -0.38 1.43e-12 Menarche (age at onset); CRC cis rs11122272 0.701 rs2011383 chr1:231479788 T/A cg06096015 chr1:231504339 EGLN1 0.38 5.61 0.3 4.23e-8 Hemoglobin concentration; CRC cis rs1499614 1.000 rs2659911 chr7:66158420 G/A cg18252515 chr7:66147081 NA -1.24 -14.6 -0.63 1.48e-37 Gout; CRC cis rs826838 0.616 rs10880738 chr12:38617762 C/T cg26384229 chr12:38710491 ALG10B -0.52 -7.52 -0.38 5.28e-13 Heart rate; CRC cis rs9322193 0.962 rs4380763 chr6:149999222 A/G cg00933542 chr6:150070202 PCMT1 0.3 6.07 0.32 3.45e-9 Lung cancer; CRC cis rs7811142 1.000 rs67239991 chr7:100046504 A/G cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.06 15.37 0.65 1.54e-40 Platelet count; CRC cis rs6951245 1.000 rs78628466 chr7:1068453 G/C cg04025307 chr7:1156635 C7orf50 0.63 6.63 0.34 1.41e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs2120019 1.000 rs12185102 chr15:75352201 G/A cg17294928 chr15:75287854 SCAMP5 -0.78 -11.31 -0.53 2.81e-25 Blood trace element (Zn levels); CRC cis rs561341 0.609 rs11658984 chr17:30186612 C/T cg00745463 chr17:30367425 LRRC37B 0.54 6.64 0.34 1.34e-10 Hip circumference adjusted for BMI; CRC trans rs2303319 0.504 rs12470830 chr2:162429996 C/T cg04269497 chr6:167369491 RNASET2 -0.75 -5.99 -0.31 5.54e-9 Cognitive function; CRC cis rs11229555 0.645 rs12283414 chr11:58176920 C/T cg15696309 chr11:58395628 NA -0.81 -10.45 -0.5 2.9e-22 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; CRC cis rs1218582 0.804 rs4845678 chr1:154853295 A/G cg16680214 chr1:154839983 KCNN3 -0.47 -9.3 -0.46 1.95e-18 Prostate cancer; CRC cis rs7811142 0.943 rs111757992 chr7:100016354 A/C cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.17 18.11 0.71 2.42e-51 Platelet count; CRC cis rs422249 0.720 rs174455 chr11:61656117 A/G cg01500311 chr11:61656094 FADS3 -0.49 -8.87 -0.44 4.67e-17 Trans fatty acid levels; CRC trans rs6762477 0.748 rs11717349 chr3:50223977 C/T cg21659725 chr3:3221576 CRBN -0.43 -6.62 -0.34 1.5e-10 Menarche (age at onset); CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg06057576 chr1:27719045 GPR3 0.46 6.18 0.32 1.87e-9 Anxiety disorder; CRC cis rs73200209 0.912 rs17498914 chr12:116675689 C/G cg01776926 chr12:116560359 MED13L -0.48 -5.91 -0.31 8.58e-9 Total body bone mineral density; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg23084309 chr19:6280164 MLLT1 -0.4 -6.03 -0.32 4.29e-9 Myopia (pathological); CRC cis rs926938 0.765 rs12407408 chr1:115234275 A/G cg12756093 chr1:115239321 AMPD1 0.66 9.72 0.47 8.69e-20 Autism; CRC cis rs4930561 0.690 rs6591334 chr11:67924559 A/G cg04465784 chr11:67976953 SUV420H1 -0.3 -6.06 -0.32 3.8e-9 Breast cancer in childhood cancer survivors;IgG glycosylation; CRC trans rs11039798 0.620 rs10838833 chr11:48238880 C/T cg27395922 chr11:50257633 LOC441601 0.49 6.2 0.32 1.71e-9 Axial length; CRC cis rs4481887 0.927 rs4523548 chr1:248472399 G/T cg13385794 chr1:248469461 NA 0.38 6.75 0.35 6.84e-11 Common traits (Other); CRC cis rs11679072 1.000 rs73110504 chr2:240449770 G/A cg03276489 chr2:240449683 NA -0.92 -9.23 -0.45 3.45e-18 Blood pressure (smoking interaction); CRC cis rs1443512 0.812 rs1867299 chr12:54329975 T/C cg17410650 chr12:54324560 NA -0.37 -6.69 -0.35 9.45e-11 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for BMI in non-smokers;Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction);Waist-hip ratio;Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour); CRC cis rs11785400 0.793 rs4736362 chr8:143741381 G/A cg24634471 chr8:143751801 JRK 0.47 6.46 0.34 3.77e-10 Schizophrenia; CRC cis rs34779708 0.931 rs10437420 chr10:35335044 A/C cg03585969 chr10:35415529 CREM -0.57 -7.66 -0.39 2.04e-13 Inflammatory bowel disease;Crohn's disease; CRC cis rs6089829 1.000 rs6089829 chr20:61669036 C/T cg08564027 chr20:61660810 NA -0.72 -12.45 -0.57 1.97e-29 Prostate cancer (SNP x SNP interaction); CRC cis rs8180040 0.966 rs60369822 chr3:47479735 A/C cg10298567 chr3:47292165 KIF9 0.37 5.98 0.31 5.79e-9 Colorectal cancer; CRC cis rs9549367 0.713 rs3024776 chr13:113827075 A/G cg00898013 chr13:113819073 PROZ 0.57 8.22 0.41 4.71e-15 Platelet distribution width; CRC cis rs7223966 1.000 rs8068603 chr17:61755211 T/A cg23903597 chr17:61704154 MAP3K3 -0.42 -5.81 -0.3 1.51e-8 Hip circumference adjusted for BMI;Body mass index; CRC cis rs7809950 0.678 rs7777950 chr7:107004672 T/C cg23024343 chr7:107201750 COG5 -0.71 -9.92 -0.48 1.9e-20 Coronary artery disease; CRC cis rs4423214 1.000 rs11233746 chr11:71171440 A/G cg05163923 chr11:71159392 DHCR7 0.66 9.2 0.45 4.22e-18 Vitamin D levels; CRC cis rs4604732 0.631 rs12039596 chr1:247624766 A/G cg12758973 chr1:247694275 LOC148824;OR2C3 0.43 6.32 0.33 8.6e-10 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CRC cis rs611744 0.538 rs59930666 chr8:109262296 T/C cg18478394 chr8:109455254 TTC35 0.4 6.0 0.31 5.24e-9 Dupuytren's disease; CRC cis rs673253 0.686 rs2819334 chr1:44014735 C/T cg10881128 chr1:44031826 PTPRF -0.22 -6.23 -0.32 1.46e-9 Intelligence (multi-trait analysis); CRC cis rs9311676 0.656 rs11917591 chr3:58368449 C/T cg06643156 chr3:58380774 PXK -0.42 -6.41 -0.33 5.04e-10 Systemic lupus erythematosus; CRC cis rs10504229 0.728 rs72650861 chr8:58153273 T/C cg02290350 chr8:58132656 NA -0.51 -6.57 -0.34 1.98e-10 Developmental language disorder (linguistic errors); CRC cis rs9916302 0.706 rs439537 chr17:37734482 T/C cg00129232 chr17:37814104 STARD3 -0.6 -7.21 -0.37 3.94e-12 Glomerular filtration rate (creatinine); CRC cis rs6496044 0.527 rs7163068 chr15:86072466 T/C cg17133734 chr15:86042851 AKAP13 0.39 6.34 0.33 7.39e-10 Interstitial lung disease; CRC cis rs79349575 0.783 rs56046215 chr17:47008757 A/T cg00947319 chr17:47005597 UBE2Z -0.34 -5.9 -0.31 9.06e-9 Type 2 diabetes; CRC cis rs3087591 0.881 rs2905804 chr17:29519995 T/C cg24425628 chr17:29625626 OMG;NF1 0.81 14.07 0.61 1.53e-35 Hip circumference; CRC cis rs8060686 0.641 rs9923710 chr16:68224018 C/T cg08314208 chr16:67682810 RLTPR -0.49 -5.88 -0.31 9.81e-9 HDL cholesterol;Metabolic syndrome; CRC cis rs7666738 0.716 rs1426660 chr4:98876792 T/A cg05340658 chr4:99064831 C4orf37 0.56 8.33 0.42 2.21e-15 Colonoscopy-negative controls vs population controls; CRC cis rs889398 0.617 rs11075742 chr16:69898934 A/G cg00738113 chr16:70207722 CLEC18C -0.35 -6.22 -0.32 1.49e-9 Body mass index; CRC cis rs9549260 0.564 rs9577107 chr13:41271676 A/T cg21288729 chr13:41239152 FOXO1 0.45 6.97 0.36 1.78e-11 Red blood cell count; CRC cis rs1707322 0.752 rs7541962 chr1:46235117 G/A cg06784218 chr1:46089804 CCDC17 0.64 11.76 0.54 7.05e-27 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC trans rs3733585 0.664 rs17245436 chr4:9958169 A/G cg26043149 chr18:55253948 FECH -0.5 -7.65 -0.39 2.21e-13 Cleft plate (environmental tobacco smoke interaction); CRC cis rs2050392 1.000 rs2183176 chr10:30698544 C/T cg25182066 chr10:30743637 MAP3K8 0.38 5.72 0.3 2.35e-8 Inflammatory bowel disease; CRC cis rs28386778 0.897 rs4968598 chr17:61835579 T/C cg11494091 chr17:61959527 GH2 0.6 10.28 0.49 1.13e-21 Prudent dietary pattern; CRC cis rs477895 0.653 rs11603212 chr11:63927810 C/T cg05016508 chr11:63871570 FLRT1;MACROD1 -0.56 -7.24 -0.37 3.26e-12 Mean platelet volume; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg11589374 chr3:126398357 NA 0.49 6.89 0.36 2.78e-11 Response to antipsychotic treatment; CRC cis rs250677 0.687 rs171636 chr5:148434545 G/A cg18129178 chr5:148520854 ABLIM3 -0.41 -6.1 -0.32 2.93e-9 Breast cancer; CRC cis rs863345 0.604 rs12044288 chr1:158463863 C/A cg12129480 chr1:158549410 OR10X1 -0.3 -6.26 -0.33 1.17e-9 Pneumococcal bacteremia; CRC cis rs12142240 0.698 rs56049453 chr1:46835468 A/G cg14993813 chr1:46806288 NSUN4 -0.48 -6.1 -0.32 2.93e-9 Menopause (age at onset); CRC cis rs4713118 0.955 rs9393847 chr6:27687973 G/A cg02683197 chr6:28174875 NA 0.57 7.29 0.37 2.33e-12 Parkinson's disease; CRC cis rs4819052 0.851 rs2877020 chr21:46658742 C/T cg19498844 chr21:46707878 POFUT2;LOC642852 0.77 10.99 0.52 3.97e-24 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs6456156 0.565 rs6456153 chr6:167472167 T/C cg07741184 chr6:167504864 NA 0.39 6.85 0.35 3.66e-11 Primary biliary cholangitis; CRC cis rs6964587 0.869 rs2374519 chr7:91541481 T/C cg17063962 chr7:91808500 NA -0.74 -12.31 -0.56 6.62e-29 Breast cancer; CRC cis rs939584 1.000 rs6756518 chr2:651483 G/A cg03610516 chr2:642275 NA -0.43 -5.94 -0.31 7.19e-9 Body mass index; CRC cis rs7917772 0.503 rs11191330 chr10:104306160 G/T cg04362960 chr10:104952993 NT5C2 -0.42 -6.02 -0.31 4.7e-9 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC cis rs8022179 0.580 rs8013228 chr14:103842650 A/G cg12935359 chr14:103987150 CKB -0.52 -7.27 -0.37 2.7e-12 Monocyte count; CRC trans rs10242455 0.702 rs73403247 chr7:99088730 G/A cg09045935 chr12:6379348 NA 1.14 8.88 0.44 4.43e-17 Blood metabolite levels; CRC cis rs1348850 0.793 rs13020788 chr2:178480714 C/A cg22681709 chr2:178499509 PDE11A -0.39 -7.34 -0.38 1.64e-12 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs6951245 1.000 rs28379681 chr7:1070539 C/T cg03188948 chr7:1209495 NA 0.63 6.52 0.34 2.64e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC trans rs9858542 0.953 rs6766131 chr3:49538932 T/C cg21665057 chr3:196295764 WDR53;FBXO45 -0.66 -9.1 -0.45 8.6e-18 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs8177253 0.665 rs12639304 chr3:133441594 A/T cg01448562 chr3:133502909 NA -0.36 -5.79 -0.3 1.61e-8 Iron status biomarkers; CRC cis rs17331151 0.573 rs11626 chr3:52873984 C/T cg06204229 chr3:52865917 ITIH4 0.6 8.31 0.42 2.63e-15 Immune reponse to smallpox (secreted IL-2); CRC cis rs3749237 1.000 rs11130216 chr3:49736172 C/A cg24308560 chr3:49941425 MST1R -0.44 -6.27 -0.33 1.15e-9 Resting heart rate; CRC cis rs4665809 0.556 rs4665322 chr2:26434605 C/G cg22920501 chr2:26401640 FAM59B -0.84 -12.46 -0.57 1.94e-29 Gut microbiome composition (summer); CRC cis rs798766 0.779 rs3134866 chr4:1723265 A/G cg05874882 chr4:1763078 NA -0.36 -6.62 -0.34 1.5e-10 Bladder cancer;Urinary bladder cancer; CRC cis rs9649213 0.593 rs6963210 chr7:97944986 G/A cg00277769 chr7:97922759 BAIAP2L1 -0.62 -11.06 -0.52 2.22e-24 Prostate cancer (SNP x SNP interaction); CRC cis rs2304069 0.954 rs2276983 chr5:149424966 C/T cg22760475 chr5:149380129 HMGXB3;TIGD6 0.7 8.27 0.41 3.31e-15 HIV-1 control; CRC cis rs7119 0.717 rs12917175 chr15:77818193 A/G cg10437265 chr15:77819839 NA 0.67 12.16 0.56 2.31e-28 Type 2 diabetes; CRC cis rs4076764 1.000 rs7528020 chr1:163426537 G/A cg06092702 chr1:163392909 NA -0.56 -8.81 -0.44 7.51e-17 Motion sickness; CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg05226292 chr8:71520850 TRAM1 0.38 6.14 0.32 2.44e-9 Obesity-related traits; CRC cis rs7552404 0.727 rs5745433 chr1:76333163 T/G cg05598546 chr1:76251766 SNORD45C;RABGGTB 0.52 5.79 0.3 1.69e-8 Blood metabolite levels;Acylcarnitine levels; CRC cis rs2811415 0.597 rs13097739 chr3:127739076 T/C cg13719885 chr3:127795394 NA -0.37 -5.72 -0.3 2.37e-8 Lung function (FEV1/FVC); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg23562514 chr4:18022479 LCORL 0.45 6.66 0.34 1.18e-10 Intelligence (multi-trait analysis); CRC cis rs2243480 0.711 rs2460426 chr7:65623129 A/G cg18252515 chr7:66147081 NA 1.23 14.35 0.62 1.34e-36 Diabetic kidney disease; CRC cis rs727505 0.521 rs66787780 chr7:124791849 G/A cg23710748 chr7:124431027 NA -0.64 -10.26 -0.49 1.34e-21 Lewy body disease; CRC cis rs6951245 0.572 rs79396675 chr7:1055047 C/T cg24642844 chr7:1081250 C7orf50 -0.95 -8.04 -0.41 1.59e-14 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs2153535 0.542 rs915353 chr6:8440370 A/G cg21535247 chr6:8435926 SLC35B3 0.48 7.24 0.37 3.19e-12 Motion sickness; CRC cis rs929354 0.742 rs2006844 chr7:157002851 G/A cg17757837 chr7:157058334 UBE3C 0.74 12.62 0.57 4.92e-30 Body mass index; CRC cis rs9875589 0.509 rs9836573 chr3:14065239 G/A cg14375111 chr3:14165186 TMEM43;CHCHD4 0.41 6.13 0.32 2.46e-9 Ovarian reserve; CRC cis rs7772486 0.686 rs1337839 chr6:146010239 A/G cg13319975 chr6:146136371 FBXO30 0.42 6.25 0.33 1.26e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs10504229 0.728 rs77197419 chr8:58150879 C/A cg05313129 chr8:58192883 C8orf71 -0.47 -6.18 -0.32 1.94e-9 Developmental language disorder (linguistic errors); CRC trans rs1005277 0.602 rs2504142 chr10:38383793 C/T cg27523141 chr10:43048294 ZNF37B 0.5 7.23 0.37 3.41e-12 Extrinsic epigenetic age acceleration; CRC trans rs11800820 0.567 rs3124119 chr1:246707816 T/C cg26885821 chr6:124125002 NKAIN2 0.38 6.09 0.32 3.11e-9 Obesity-related traits; CRC trans rs1346081 0.786 rs1425645 chr4:68028175 C/T cg01109287 chr10:65281299 REEP3 0.52 6.16 0.32 2.17e-9 Intelligence (multi-trait analysis); CRC cis rs798554 0.757 rs1182188 chr7:2869985 T/C cg17321639 chr7:2759063 NA -0.52 -7.02 -0.36 1.3e-11 Height; CRC cis rs208520 0.526 rs9351542 chr6:66788571 A/G cg07460842 chr6:66804631 NA -1.16 -24.69 -0.81 7.19e-77 Exhaled nitric oxide output; CRC cis rs477895 1.000 rs7938380 chr11:64034866 G/A cg19465662 chr11:63993652 NUDT22;TRPT1 0.7 7.45 0.38 8.53e-13 Mean platelet volume; CRC cis rs5750830 0.649 rs4821895 chr22:39823015 A/G cg05872129 chr22:39784769 NA -0.61 -11.92 -0.55 1.77e-27 Intelligence (multi-trait analysis); CRC cis rs79976124 0.760 rs74295030 chr6:66654441 T/C cg07460842 chr6:66804631 NA 0.75 9.36 0.46 1.31e-18 Type 2 diabetes; CRC trans rs7615952 0.604 rs9837847 chr3:125623919 G/A cg07211511 chr3:129823064 LOC729375 -1.11 -12.92 -0.58 3.75e-31 Blood pressure (smoking interaction); CRC cis rs208520 0.690 rs1580430 chr6:66715162 T/A cg07460842 chr6:66804631 NA 1.01 13.9 0.61 7.03e-35 Exhaled nitric oxide output; CRC cis rs877282 1.000 rs2004479 chr10:770854 G/A cg06581033 chr10:766294 NA -0.47 -5.65 -0.3 3.41e-8 Uric acid levels; CRC cis rs881375 0.967 rs876445 chr9:123677102 A/T cg09586646 chr9:123605570 PSMD5;LOC253039 0.51 7.05 0.36 1.04e-11 Rheumatoid arthritis; CRC cis rs7264396 0.563 rs56941405 chr20:34313426 C/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.49 -6.74 -0.35 6.94e-11 Total cholesterol levels; CRC cis rs6502050 0.835 rs35192339 chr17:80119106 G/A cg19223190 chr17:80058835 NA 0.39 6.23 0.32 1.43e-9 Life satisfaction; CRC cis rs734999 0.549 rs3828154 chr1:2524943 G/A cg18854424 chr1:2615690 NA 0.5 9.88 0.48 2.55e-20 Ulcerative colitis; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg08498597 chr11:67163067 RAD9A -0.37 -6.75 -0.35 6.62e-11 Liver disease severity in Alagille syndrome; CRC cis rs9039 0.959 rs12148920 chr16:9183900 C/G cg08831531 chr16:9218945 NA 0.54 7.53 0.38 4.84e-13 Menopause (age at onset); CRC cis rs10883723 0.703 rs7898410 chr10:104245858 T/C cg04362960 chr10:104952993 NT5C2 -0.43 -6.03 -0.32 4.4e-9 Allergic disease (asthma, hay fever or eczema); CRC cis rs11098499 0.909 rs78332141 chr4:120375782 C/T cg24375607 chr4:120327624 NA 0.52 7.83 0.4 6.95e-14 Corneal astigmatism; CRC cis rs6540559 0.673 rs7525951 chr1:210018306 C/T cg22029157 chr1:209979665 IRF6 -0.62 -7.41 -0.38 1.08e-12 Cleft lip with or without cleft palate; CRC cis rs2228479 0.850 rs62052212 chr16:89981960 G/A cg12064134 chr16:90016061 DEF8 -0.65 -5.98 -0.31 5.89e-9 Skin colour saturation; CRC cis rs34172651 0.917 rs35283675 chr16:24820393 A/G cg06028605 chr16:24865363 SLC5A11 0.44 7.92 0.4 3.75e-14 Intelligence (multi-trait analysis); CRC cis rs3806843 0.966 rs2563266 chr5:140136915 C/A cg16607685 chr5:140181889 PCDHA2;PCDHA1;PCDHA3 0.25 5.91 0.31 8.7e-9 Depressive symptoms (multi-trait analysis); CRC cis rs7927771 0.832 rs10838704 chr11:47424717 T/C cg05585544 chr11:47624801 NA -0.59 -10.64 -0.51 6.55e-23 Subjective well-being; CRC cis rs9467773 1.000 rs6910899 chr6:26524339 A/G cg09904177 chr6:26538194 HMGN4 0.86 14.68 0.63 7.22e-38 Intelligence (multi-trait analysis); CRC cis rs2239547 0.657 rs2072391 chr3:52862200 C/T cg18404041 chr3:52824283 ITIH1 -0.41 -7.65 -0.39 2.25e-13 Schizophrenia; CRC cis rs1728785 1.000 rs1624718 chr16:68580385 A/G cg02972257 chr16:68554789 NA -0.58 -7.24 -0.37 3.21e-12 Ulcerative colitis; CRC cis rs3858526 0.796 rs9645652 chr11:5944264 C/T cg02574844 chr11:5959923 NA -0.41 -5.83 -0.31 1.35e-8 DNA methylation (variation); CRC trans rs7613875 0.543 rs34034116 chr3:49959156 C/A cg21659725 chr3:3221576 CRBN 0.46 6.61 0.34 1.59e-10 Body mass index; CRC cis rs6921919 0.583 rs3800328 chr6:28390843 C/T cg21251018 chr6:28226885 NKAPL 0.4 6.08 0.32 3.25e-9 Autism spectrum disorder or schizophrenia; CRC cis rs10504229 0.683 rs7827881 chr8:58132137 C/T cg22535103 chr8:58192502 C8orf71 -0.69 -9.23 -0.45 3.5e-18 Developmental language disorder (linguistic errors); CRC cis rs8180040 0.726 rs4682842 chr3:46982773 C/G cg02527881 chr3:46936655 PTH1R 0.42 7.54 0.38 4.75e-13 Colorectal cancer; CRC cis rs56176327 0.532 rs9849038 chr3:49771990 A/G cg13072238 chr3:49761600 GMPPB -0.48 -5.68 -0.3 2.89e-8 Intelligence (multi-trait analysis); CRC cis rs921968 0.540 rs7582329 chr2:219620909 C/T cg02176678 chr2:219576539 TTLL4 -0.39 -6.31 -0.33 8.83e-10 Mean corpuscular hemoglobin concentration; CRC cis rs7493 0.950 rs12704794 chr7:95036133 A/T cg17330251 chr7:94953956 PON1 -0.56 -7.4 -0.38 1.17e-12 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs9467711 0.606 rs12174602 chr6:26372827 C/T cg14345882 chr6:26364793 BTN3A2 0.66 5.76 0.3 1.92e-8 Autism spectrum disorder or schizophrenia; CRC trans rs3733585 0.699 rs62294331 chr4:9959889 A/G cg26043149 chr18:55253948 FECH -0.5 -7.62 -0.39 2.81e-13 Cleft plate (environmental tobacco smoke interaction); CRC cis rs4665809 0.590 rs4665837 chr2:26434022 C/A cg22920501 chr2:26401640 FAM59B -0.87 -12.36 -0.56 4.43e-29 Gut microbiome composition (summer); CRC cis rs11250464 0.517 rs2387667 chr10:1430761 T/C cg02408697 chr10:1416920 ADARB2 0.39 5.62 0.3 3.98e-8 Radiation response; CRC cis rs731174 0.802 rs631102 chr1:38178836 C/T cg06917450 chr1:38156652 C1orf109 -0.52 -7.0 -0.36 1.47e-11 Prostate cancer (SNP x SNP interaction); CRC cis rs2479724 0.935 rs1887718 chr6:41857691 C/T cg17623882 chr6:41773611 USP49 -0.56 -9.75 -0.47 6.58e-20 Menarche (age at onset); CRC trans rs10504229 1.000 rs17217047 chr8:58180296 G/A cg04077850 chr5:125800366 GRAMD3 0.37 6.27 0.33 1.15e-9 Developmental language disorder (linguistic errors); CRC cis rs10540 1.000 rs117339389 chr11:505025 T/A cg21784768 chr11:537496 LRRC56 -0.69 -6.45 -0.33 4.06e-10 Body mass index; CRC cis rs709400 0.859 rs7154948 chr14:104022944 C/T cg12935359 chr14:103987150 CKB -0.39 -6.1 -0.32 2.9e-9 Body mass index; CRC cis rs6964587 0.967 rs12671991 chr7:91559481 T/C cg17063962 chr7:91808500 NA -0.77 -13.0 -0.58 1.76e-31 Breast cancer; CRC cis rs7680126 0.626 rs929575 chr4:10196886 C/G cg00071950 chr4:10020882 SLC2A9 -0.52 -6.61 -0.34 1.52e-10 Urate levels in lean individuals;Urate levels in overweight individuals;Urate levels in obese individuals; CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg02458384 chr16:2021763 TBL3 0.38 6.12 0.32 2.61e-9 Obesity-related traits; CRC cis rs9325144 0.555 rs7301258 chr12:38706942 C/T cg13010199 chr12:38710504 ALG10B 0.39 5.7 0.3 2.62e-8 Morning vs. evening chronotype; CRC trans rs8177876 0.822 rs56119129 chr16:81118266 C/T cg09779152 chr17:73205364 NUP85 0.61 5.99 0.31 5.49e-9 Plasma omega-3 polyunsaturated fatty acid level (eicosapentaenoic acid); CRC cis rs7412746 0.658 rs12405726 chr1:150956128 G/A cg15448220 chr1:150897856 SETDB1 0.55 7.69 0.39 1.71e-13 Melanoma; CRC cis rs79387448 0.745 rs74560841 chr2:103149210 G/A cg00507830 chr2:103233733 NA 0.64 6.46 0.34 3.73e-10 Gut microbiota (bacterial taxa); CRC cis rs910316 0.712 rs175015 chr14:75457075 A/C cg03030879 chr14:75389066 RPS6KL1 0.39 5.8 0.3 1.59e-8 Height; CRC cis rs10512697 1.000 rs13189312 chr5:3545313 T/C cg19473799 chr5:3511975 NA -0.76 -5.94 -0.31 7.41e-9 Immune response to smallpox vaccine (IL-6); CRC cis rs10479542 0.784 rs7702303 chr5:178986436 G/A cg00080972 chr5:178986291 RUFY1 0.49 9.66 0.47 1.3e-19 Lung cancer; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg23029100 chr15:76603787 ETFA 0.44 6.19 0.32 1.79e-9 Anxiety disorder; CRC cis rs763014 0.932 rs2384975 chr16:651115 G/T cg03804128 chr16:635623 NA 0.31 7.42 0.38 1.03e-12 Height; CRC cis rs853679 0.517 rs17774663 chr6:28120898 G/A cg15845792 chr6:28175446 NA 1.04 13.89 0.61 7.67e-35 Depression; CRC cis rs2929278 0.589 rs2411284 chr15:44038899 C/T cg02155558 chr15:43621948 ADAL;LCMT2 -0.45 -6.29 -0.33 9.98e-10 Schizophrenia; CRC cis rs2115630 1.000 rs2879828 chr15:85361977 G/T cg09876464 chr15:85330779 ZNF592 0.47 8.23 0.41 4.38e-15 P wave terminal force; CRC cis rs9488822 0.676 rs6918059 chr6:116349041 C/T cg18764771 chr6:116381957 FRK 0.25 7.29 0.37 2.3e-12 Cholesterol, total;LDL cholesterol; CRC cis rs6860806 0.507 rs635619 chr5:131720265 G/A cg12564285 chr5:131593104 PDLIM4 -0.46 -7.76 -0.39 1.05e-13 Breast cancer; CRC cis rs780096 0.506 rs1647265 chr2:27692261 A/G cg12648201 chr2:27665141 KRTCAP3 -0.31 -6.28 -0.33 1.05e-9 Total body bone mineral density; CRC cis rs13191362 0.935 rs35049401 chr6:162968464 T/G cg23758597 chr6:163146217 PARK2 -0.59 -5.91 -0.31 8.72e-9 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs3771570 1.000 rs59536819 chr2:242272388 A/G cg21155796 chr2:242212141 HDLBP 0.64 6.97 0.36 1.72e-11 Prostate cancer; CRC cis rs2882667 0.898 rs2351465 chr5:138363851 A/C cg09476006 chr5:138032270 NA 0.45 7.47 0.38 7.24e-13 Age-related hearing impairment (SNP x SNP interaction); CRC trans rs561341 0.505 rs548298 chr17:30297494 C/A cg27661571 chr11:113659931 NA -0.77 -9.59 -0.47 2.24e-19 Hip circumference adjusted for BMI; CRC cis rs7208859 0.623 rs12006 chr17:29110652 G/A cg01831904 chr17:28903510 LRRC37B2 -0.63 -6.53 -0.34 2.51e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs2842992 0.872 rs2758315 chr6:160158640 T/C cg19482086 chr6:160211437 TCP1;MRPL18 0.72 9.47 0.46 5.73e-19 Age-related macular degeneration (geographic atrophy); CRC cis rs6952808 0.692 rs12666575 chr7:2004421 C/T cg21782813 chr7:2030301 MAD1L1 0.51 8.56 0.43 4.52e-16 Bipolar disorder and schizophrenia; CRC cis rs9811920 0.638 rs2452321 chr3:99638836 T/C cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G 0.45 6.1 0.32 3.04e-9 Axial length; CRC cis rs7586879 0.765 rs6545758 chr2:25074874 C/T cg22495460 chr2:25135724 ADCY3 0.76 12.79 0.58 1.14e-30 Body mass index; CRC trans rs11168936 0.637 rs10875942 chr12:49670854 A/G cg23665973 chr2:219757534 WNT10A -0.45 -6.46 -0.34 3.75e-10 Cancer (pleiotropy); CRC cis rs9649213 0.593 rs11766808 chr7:97915376 A/G cg00277769 chr7:97922759 BAIAP2L1 -0.61 -10.79 -0.51 1.87e-23 Prostate cancer (SNP x SNP interaction); CRC cis rs59918340 0.764 rs4961258 chr8:142232878 A/G cg23750338 chr8:142222470 SLC45A4 -0.61 -11.27 -0.53 3.94e-25 Immature fraction of reticulocytes; CRC cis rs4665809 0.556 rs4665322 chr2:26434605 C/G cg04944784 chr2:26401820 FAM59B -0.87 -11.78 -0.54 5.83e-27 Gut microbiome composition (summer); CRC cis rs3741404 0.594 rs11231704 chr11:63898182 C/T cg05555928 chr11:63887634 MACROD1 0.49 8.35 0.42 1.94e-15 Platelet count; CRC cis rs2228479 0.850 rs17226666 chr16:89835401 G/A cg06656553 chr16:89960601 TCF25 -0.7 -5.82 -0.31 1.37e-8 Skin colour saturation; CRC cis rs9322193 0.884 rs9688699 chr6:150054816 A/G cg13206674 chr6:150067644 NUP43 0.65 9.4 0.46 9.22e-19 Lung cancer; CRC cis rs243505 0.660 rs243487 chr7:148448211 G/A cg09806900 chr7:148480153 CUL1 -0.59 -7.5 -0.38 5.93e-13 Inflammatory bowel disease;Crohn's disease; CRC cis rs2072499 0.966 rs2984615 chr1:156165317 G/C cg25208724 chr1:156163844 SLC25A44 1.1 26.74 0.83 1.69e-84 Testicular germ cell tumor; CRC cis rs2882667 0.659 rs288037 chr5:138208441 A/G cg09476006 chr5:138032270 NA 0.54 8.92 0.44 3.21e-17 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs9649213 0.593 rs13246942 chr7:97915021 C/T cg21770322 chr7:97807741 LMTK2 0.55 9.29 0.46 2.16e-18 Prostate cancer (SNP x SNP interaction); CRC cis rs2075371 0.637 rs13245165 chr7:133951492 A/T cg02659138 chr7:134003124 SLC35B4 0.39 6.62 0.34 1.46e-10 Mean platelet volume; CRC cis rs1355223 0.583 rs2915238 chr11:34884405 C/A cg24088639 chr11:34937564 PDHX;APIP -0.6 -8.64 -0.43 2.47e-16 Systemic lupus erythematosus and Systemic sclerosis; CRC cis rs60843830 1.000 rs55946380 chr2:268293 A/G cg00108164 chr2:264199 ACP1;SH3YL1 0.61 9.64 0.47 1.51e-19 Spherical equivalent (joint analysis main effects and education interaction); CRC cis rs4665809 1.000 rs3910272 chr2:26287842 T/A cg22920501 chr2:26401640 FAM59B -0.57 -7.37 -0.38 1.42e-12 Gut microbiome composition (summer); CRC cis rs6570726 0.846 rs372904 chr6:145887425 T/C cg23711669 chr6:146136114 FBXO30 0.66 10.96 0.52 4.98e-24 Lobe attachment (rater-scored or self-reported); CRC cis rs8105895 0.935 rs62111032 chr19:22281349 C/G cg02912127 chr19:22235281 ZNF257 -0.41 -5.71 -0.3 2.54e-8 Body mass index (change over time); CRC cis rs17641971 0.684 rs7011891 chr8:49983538 A/C cg00325661 chr8:49890786 NA 0.37 6.23 0.32 1.4e-9 Blood metabolite levels; CRC cis rs10089 1.000 rs4835944 chr5:127490870 A/G cg25462716 chr5:127418816 SLC12A2;FLJ33630 -0.71 -9.38 -0.46 1.1e-18 Ileal carcinoids; CRC trans rs1005277 0.579 rs2474572 chr10:38385316 A/G cg17830980 chr10:43048298 ZNF37B -0.57 -9.52 -0.46 3.76e-19 Extrinsic epigenetic age acceleration; CRC cis rs6076065 0.723 rs2424537 chr20:23382026 T/C cg11657817 chr20:23433608 CST11 0.44 6.46 0.34 3.68e-10 Facial morphology (factor 15, philtrum width); CRC cis rs3784262 0.967 rs12148907 chr15:58296450 T/A cg12031962 chr15:58353849 ALDH1A2 -0.33 -5.86 -0.31 1.11e-8 Barrett's esophagus;Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined); CRC cis rs7772486 0.875 rs1125461 chr6:146417653 C/T cg23711669 chr6:146136114 FBXO30 0.65 11.19 0.53 7.37e-25 Lobe attachment (rater-scored or self-reported); CRC cis rs4689388 0.889 rs13128674 chr4:6294517 C/T cg25554036 chr4:6271136 WFS1 0.53 8.7 0.43 1.59e-16 Type 2 diabetes and other traits;Type 2 diabetes; CRC cis rs995000 0.931 rs10889344 chr1:63033941 T/C cg19896129 chr1:63156450 NA -0.43 -6.7 -0.35 8.85e-11 Triglyceride levels; CRC cis rs6860806 1.000 rs6860806 chr5:131640536 C/T cg22638593 chr5:131593259 PDLIM4 -0.31 -5.66 -0.3 3.24e-8 Breast cancer; CRC cis rs7914558 0.966 rs12569617 chr10:104729996 T/C cg04362960 chr10:104952993 NT5C2 0.62 9.38 0.46 1.1e-18 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs10256972 0.577 rs2949179 chr7:1209885 C/G cg23708337 chr7:1209742 NA 0.51 7.9 0.4 4.34e-14 Longevity;Endometriosis; CRC cis rs11148252 0.538 rs2274202 chr13:52722798 C/A cg02158880 chr13:53174818 NA 0.42 6.02 0.31 4.78e-9 Lewy body disease; CRC cis rs11723261 0.582 rs11733927 chr4:166828 A/G cg12746427 chr4:53362 ZNF718;ZNF595 0.49 6.47 0.34 3.61e-10 Immune response to smallpox vaccine (IL-6); CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg03361557 chr19:19774500 ATP13A1 0.42 6.88 0.35 3.05e-11 Obesity-related traits; CRC cis rs6570726 0.791 rs9322029 chr6:145906683 A/G cg23711669 chr6:146136114 FBXO30 0.68 11.35 0.53 2.09e-25 Lobe attachment (rater-scored or self-reported); CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg08330117 chr8:90770456 RIPK2 0.49 6.32 0.33 8.27e-10 Thyroid stimulating hormone; CRC cis rs425277 0.628 rs262668 chr1:2082602 A/G cg24578937 chr1:2090814 PRKCZ 0.42 7.59 0.39 3.42e-13 Height; CRC cis rs9814567 0.806 rs12637301 chr3:134317966 G/T cg06109529 chr3:134205091 CEP63;ANAPC13 -0.68 -10.11 -0.49 4.15e-21 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs7945705 0.875 rs2653616 chr11:8885892 A/G cg14711859 chr11:8959438 ASCL3 0.45 7.52 0.38 5.21e-13 Hemoglobin concentration; CRC cis rs9660180 0.967 rs9660106 chr1:1797947 A/G cg17747265 chr1:1875780 NA -0.77 -13.36 -0.59 7.73e-33 Body mass index; CRC cis rs6951245 0.572 rs73264028 chr7:1045455 G/A cg21664854 chr7:1097933 C7orf50;GPR146 0.66 5.7 0.3 2.63e-8 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs1552172 0.887 rs12405132 chr1:145644984 A/G cg11743829 chr1:145714124 CD160 0.37 5.65 0.3 3.4e-8 Breast cancer; CRC cis rs9467773 1.000 rs6930120 chr6:26555484 A/G cg09904177 chr6:26538194 HMGN4 0.85 14.85 0.63 1.61e-38 Intelligence (multi-trait analysis); CRC cis rs7647973 0.667 rs9869256 chr3:49624095 T/G cg03060546 chr3:49711283 APEH 0.62 6.36 0.33 6.93e-10 Menarche (age at onset); CRC cis rs4711350 1.000 rs4711350 chr6:33741716 A/G cg07979401 chr6:33739406 LEMD2 -0.48 -6.18 -0.32 1.94e-9 Schizophrenia; CRC cis rs13118159 0.550 rs4974612 chr4:1364543 A/G cg05025164 chr4:1340916 KIAA1530 0.59 8.38 0.42 1.58e-15 Longevity; CRC cis rs898097 0.737 rs3785521 chr17:80895769 A/G cg03160526 chr17:80928410 B3GNTL1 0.45 6.44 0.33 4.15e-10 Breast cancer; CRC trans rs16846053 0.584 rs57840078 chr2:162402459 T/G cg09481857 chr22:21368659 P2RX6;MGC16703 -0.64 -6.01 -0.31 4.88e-9 Blood osmolality (transformed sodium); CRC cis rs2880765 0.835 rs7178991 chr15:86050944 G/C cg17133734 chr15:86042851 AKAP13 0.42 6.86 0.35 3.44e-11 Coronary artery disease; CRC trans rs1005277 0.579 rs1780139 chr10:38503018 C/T cg17830980 chr10:43048298 ZNF37B -0.57 -9.66 -0.47 1.38e-19 Extrinsic epigenetic age acceleration; CRC cis rs1878931 0.543 rs17612463 chr16:3420479 G/C cg02880119 chr16:3481970 NA -0.41 -5.8 -0.3 1.55e-8 Body mass index (adult); CRC cis rs2415984 0.644 rs1669808 chr14:46930473 A/G cg14871534 chr14:47121158 RPL10L 0.43 6.16 0.32 2.15e-9 Number of children ever born; CRC cis rs10540 1.000 rs61876341 chr11:495892 C/G cg08200582 chr11:442649 ANO9 -0.71 -7.42 -0.38 9.82e-13 Body mass index; CRC cis rs10464366 0.544 rs1525799 chr7:39153131 C/G cg21665744 chr7:39171113 POU6F2 -0.42 -5.68 -0.3 3.01e-8 IgG glycosylation; CRC cis rs9403521 0.947 rs7741424 chr6:143981662 G/A cg18240653 chr6:144019428 PHACTR2 -0.56 -6.15 -0.32 2.23e-9 Obesity-related traits; CRC cis rs35110281 0.633 rs4819289 chr21:45120237 A/G cg01579765 chr21:45077557 HSF2BP -0.31 -5.73 -0.3 2.27e-8 Mean corpuscular volume; CRC cis rs951366 0.789 rs7536483 chr1:205718858 A/T cg14159672 chr1:205819179 PM20D1 0.72 10.48 0.5 2.26e-22 Menarche (age at onset); CRC cis rs951366 0.559 rs823101 chr1:205667006 T/C cg14893161 chr1:205819251 PM20D1 0.77 11.22 0.53 5.89e-25 Menarche (age at onset); CRC trans rs208520 0.690 rs207108 chr6:66794096 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.08 -15.36 -0.65 1.56e-40 Exhaled nitric oxide output; CRC cis rs9649213 0.593 rs10808107 chr7:97951671 T/C cg21770322 chr7:97807741 LMTK2 0.51 8.34 0.42 2.06e-15 Prostate cancer (SNP x SNP interaction); CRC cis rs9916302 0.851 rs9904919 chr17:37556431 G/C cg07936489 chr17:37558343 FBXL20 0.77 11.55 0.54 4.07e-26 Glomerular filtration rate (creatinine); CRC cis rs12410462 0.581 rs7547204 chr1:227560909 C/T cg23173402 chr1:227635558 NA 0.73 6.77 0.35 5.79e-11 Major depressive disorder; CRC cis rs1552244 1.000 rs6442147 chr3:10078247 A/G cg16606324 chr3:10149918 C3orf24 0.69 9.61 0.47 2.01e-19 Alzheimer's disease; CRC cis rs10504229 0.683 rs11786843 chr8:58133629 T/C cg02290350 chr8:58132656 NA -0.58 -8.21 -0.41 5e-15 Developmental language disorder (linguistic errors); CRC cis rs2179367 0.959 rs9373592 chr6:149733255 A/T cg07828024 chr6:149772892 ZC3H12D -0.38 -6.1 -0.32 2.98e-9 Dupuytren's disease; CRC cis rs722599 0.748 rs20578 chr14:75367807 C/T cg08847533 chr14:75593920 NEK9 -0.43 -5.89 -0.31 9.6e-9 IgG glycosylation; CRC cis rs2336384 1.000 rs2336384 chr1:12046063 A/C cg13216073 chr1:12042593 MFN2 -0.48 -7.01 -0.36 1.39e-11 Platelet count; CRC cis rs798554 0.959 rs798556 chr7:2759002 C/A cg19346786 chr7:2764209 NA -0.41 -7.25 -0.37 2.96e-12 Height; CRC trans rs7613875 0.641 rs6793528 chr3:50100188 C/A cg21665057 chr3:196295764 WDR53;FBXO45 -0.47 -7.06 -0.36 9.98e-12 Body mass index; CRC cis rs7833790 0.963 rs7836040 chr8:82698328 G/A cg17211192 chr8:82754475 SNX16 -0.53 -6.56 -0.34 2.1e-10 Diastolic blood pressure; CRC cis rs4253772 0.637 rs8135997 chr22:46651366 G/A cg24881330 chr22:46731750 TRMU 0.56 6.63 0.34 1.35e-10 LDL cholesterol;Cholesterol, total; CRC cis rs9372498 0.536 rs9481825 chr6:118876092 C/T cg01339444 chr6:118972232 C6orf204 0.51 5.86 0.31 1.11e-8 Diastolic blood pressure; CRC cis rs11758351 0.587 rs10484436 chr6:26237155 C/T cg01420254 chr6:26195488 NA 0.74 8.02 0.4 1.84e-14 Gout;Renal underexcretion gout; CRC cis rs2933343 0.679 rs789221 chr3:128591625 A/G cg11901034 chr3:128598214 ACAD9 -0.55 -8.09 -0.41 1.13e-14 IgG glycosylation; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg08066755 chr14:58765184 FLJ31306;ARID4A 0.48 6.85 0.35 3.73e-11 Intelligence (multi-trait analysis); CRC trans rs6687430 0.512 rs11121587 chr1:10618109 A/G cg20645065 chr1:21836138 ALPL -0.4 -6.02 -0.31 4.71e-9 Hand grip strength; CRC cis rs6543140 0.964 rs10169192 chr2:103072211 A/G cg09003973 chr2:102972529 NA 0.41 5.83 0.31 1.33e-8 Blood protein levels; CRC cis rs12477438 1.000 rs6542873 chr2:99824965 C/T cg14399236 chr2:99771627 LIPT1;TSGA10 -0.64 -8.0 -0.4 2.08e-14 Chronic sinus infection; CRC cis rs7666738 0.830 rs732299 chr4:98995389 C/T cg17366294 chr4:99064904 C4orf37 0.43 7.27 0.37 2.66e-12 Colonoscopy-negative controls vs population controls; CRC cis rs7584330 0.704 rs72620821 chr2:238362615 C/A cg16989719 chr2:238392110 NA -0.4 -6.69 -0.35 9.83e-11 Prostate cancer; CRC cis rs2735413 0.918 rs11643649 chr16:78081199 T/C cg04733911 chr16:78082701 NA -0.44 -7.37 -0.38 1.38e-12 Systolic blood pressure (alcohol consumption interaction); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg12148714 chr16:69345699 VPS4A 0.45 6.29 0.33 1e-9 Response to antipsychotic treatment; CRC trans rs208520 0.770 rs2224422 chr6:66883993 G/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.91 -12.38 -0.56 3.59e-29 Exhaled nitric oxide output; CRC trans rs11088226 0.846 rs13047501 chr21:33924660 G/A cg09050820 chr6:167586206 TCP10L2 0.68 8.67 0.43 1.96e-16 Gastritis; CRC cis rs7659604 0.539 rs3217773 chr4:122739121 A/G cg20573242 chr4:122745356 CCNA2 0.57 8.5 0.42 6.7e-16 Type 2 diabetes; CRC cis rs1524976 0.760 rs11706564 chr3:65443720 G/C cg16238336 chr3:65465873 MAGI1 -0.47 -6.9 -0.36 2.72e-11 PR interval; CRC cis rs6582630 0.519 rs7294292 chr12:38349540 C/T cg26384229 chr12:38710491 ALG10B 0.69 9.79 0.48 4.92e-20 Drug-induced liver injury (flucloxacillin); CRC cis rs4319547 1.000 rs9705654 chr12:123083508 T/C cg23029597 chr12:123009494 RSRC2 -0.62 -8.02 -0.4 1.92e-14 Body mass index; CRC cis rs995000 0.929 rs12038768 chr1:63040728 G/T cg19896129 chr1:63156450 NA 0.39 5.72 0.3 2.39e-8 Triglyceride levels; CRC cis rs1707322 0.752 rs11211173 chr1:46219376 C/T cg03146154 chr1:46216737 IPP 0.68 9.85 0.48 3.13e-20 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC trans rs6601327 0.641 rs11785923 chr8:9587674 G/C cg06636001 chr8:8085503 FLJ10661 -0.49 -7.19 -0.37 4.5e-12 Multiple myeloma (hyperdiploidy); CRC cis rs6088580 0.561 rs3761147 chr20:32996689 G/T cg08999081 chr20:33150536 PIGU -0.6 -11.37 -0.53 1.73e-25 Glomerular filtration rate (creatinine); CRC cis rs4363385 0.747 rs946101 chr1:152972032 C/T cg25856811 chr1:152973957 SPRR3 0.25 6.88 0.35 3.02e-11 Inflammatory skin disease; CRC cis rs6121246 0.954 rs73241710 chr20:30424956 G/A cg13852791 chr20:30311386 BCL2L1 0.63 9.81 0.48 4.31e-20 Mean corpuscular hemoglobin; CRC cis rs853679 0.517 rs6922063 chr6:28094366 G/A cg03623178 chr6:28175578 NA 0.94 12.33 0.56 5.52e-29 Depression; CRC cis rs801193 0.569 rs11761542 chr7:66218196 G/A cg18876405 chr7:65276391 NA 0.51 8.24 0.41 4.17e-15 Aortic root size; CRC trans rs951252 0.504 rs11734405 chr4:146081096 C/T cg02909592 chr3:149181944 NA -0.45 -6.0 -0.31 5.14e-9 Hip circumference; CRC cis rs7493 1.000 rs2040993 chr7:95047300 T/A cg01874867 chr7:94954059 PON1 -0.48 -6.19 -0.32 1.81e-9 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs6502050 0.835 rs9900072 chr17:80114360 C/G cg22110888 chr17:80059540 CCDC57 0.41 6.51 0.34 2.86e-10 Life satisfaction; CRC cis rs12681287 0.547 rs9942792 chr8:87509046 C/T cg27223183 chr8:87520930 FAM82B -0.52 -7.37 -0.38 1.38e-12 Caudate activity during reward; CRC cis rs1218582 0.688 rs58629129 chr1:154910930 T/C cg06221963 chr1:154839813 KCNN3 -0.78 -13.78 -0.61 1.99e-34 Prostate cancer; CRC trans rs1569175 1.000 rs1509830 chr2:200908143 G/A cg19477977 chr2:235599692 NA 0.68 6.16 0.32 2.09e-9 Response to treatment for acute lymphoblastic leukemia; CRC cis rs274567 0.501 rs581968 chr5:131710202 G/A cg18758796 chr5:131593413 PDLIM4 -0.4 -6.46 -0.34 3.78e-10 Blood metabolite levels; CRC trans rs2797160 1.000 rs2747719 chr6:126009214 C/T cg05039488 chr6:79577232 IRAK1BP1 0.49 7.29 0.37 2.25e-12 Endometrial cancer; CRC trans rs11098499 0.779 rs10011097 chr4:120310359 T/G cg25214090 chr10:38739885 LOC399744 0.63 9.79 0.47 4.8e-20 Corneal astigmatism; CRC trans rs2228479 0.867 rs57492102 chr16:89975572 A/G cg24644049 chr4:85504048 CDS1 0.74 7.25 0.37 2.95e-12 Skin colour saturation; CRC cis rs6502050 0.835 rs8073351 chr17:80127625 A/G cg19223190 chr17:80058835 NA 0.38 6.02 0.32 4.64e-9 Life satisfaction; CRC cis rs847577 0.674 rs7790479 chr7:97713101 C/G cg24562669 chr7:97807699 LMTK2 0.76 16.52 0.67 4.67e-45 Breast cancer; CRC cis rs4862750 0.914 rs6553026 chr4:187875648 C/T cg10295955 chr4:187884368 NA -1.0 -23.48 -0.79 2.81e-72 Lobe attachment (rater-scored or self-reported); CRC cis rs9381040 0.655 rs9381032 chr6:41044986 A/T cg09580153 chr6:41068724 NFYA;LOC221442 -0.45 -6.46 -0.34 3.85e-10 Alzheimer's disease (late onset); CRC cis rs9322193 0.923 rs12526675 chr6:150050676 A/C cg05861140 chr6:150128134 PCMT1 0.37 5.74 0.3 2.17e-8 Lung cancer; CRC cis rs6546550 0.901 rs6546559 chr2:70145833 G/A cg02498382 chr2:70120550 SNRNP27 -0.56 -9.49 -0.46 4.98e-19 Prevalent atrial fibrillation; CRC trans rs7395662 1.000 rs12421879 chr11:48689978 A/T cg21153622 chr11:89784906 NA -0.48 -7.72 -0.39 1.45e-13 HDL cholesterol; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg21395782 chr19:19626814 NDUFA13;TSSK6 0.51 6.9 0.36 2.62e-11 Thyroid stimulating hormone; CRC cis rs35306767 0.903 rs11253458 chr10:882843 T/C cg20503657 chr10:835505 NA 0.93 11.28 0.53 3.59e-25 Eosinophil percentage of granulocytes; CRC cis rs7517126 1.000 rs57426012 chr1:196837456 T/A cg13682187 chr1:196946512 CFHR5 -0.43 -6.26 -0.33 1.2e-9 Blood protein levels; CRC cis rs2976388 0.609 rs2572908 chr8:143802636 A/G cg15511327 chr8:143859410 LYNX1 0.39 6.97 0.36 1.79e-11 Urinary tract infection frequency; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg03839322 chr16:57816956 KIFC3 -0.39 -6.08 -0.32 3.37e-9 Response to antipsychotic treatment; CRC trans rs1814175 0.817 rs28544182 chr11:50049577 G/T cg03929089 chr4:120376271 NA -0.96 -19.27 -0.73 6.37e-56 Height; CRC cis rs2243480 1.000 rs4718334 chr7:65789454 G/A cg25985355 chr7:65971099 NA 0.51 5.8 0.3 1.58e-8 Diabetic kidney disease; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg03152577 chr1:54411898 LRRC42;HSPB11 0.45 7.37 0.38 1.39e-12 Liver disease severity in Alagille syndrome; CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg03051979 chr16:58283909 CCDC113 0.37 6.01 0.31 4.88e-9 Obesity-related traits; CRC cis rs7926971 0.729 rs5016300 chr11:12659464 G/A cg25843174 chr11:12811716 TEAD1 0.35 6.08 0.32 3.28e-9 Height; CRC cis rs4423214 0.879 rs736894 chr11:71152258 A/G cg13043300 chr11:71146211 DHCR7 0.44 6.16 0.32 2.16e-9 Vitamin D levels; CRC cis rs709400 0.663 rs10141388 chr14:103939679 A/G cg12935359 chr14:103987150 CKB -0.5 -8.2 -0.41 5.35e-15 Body mass index; CRC cis rs2730245 0.527 rs712199 chr7:158662250 A/G cg24397884 chr7:158709396 WDR60 0.91 11.13 0.52 1.26e-24 Height; CRC cis rs875971 0.862 rs801203 chr7:66023012 A/G cg18252515 chr7:66147081 NA 0.43 6.21 0.32 1.62e-9 Aortic root size; CRC cis rs9788333 0.962 rs34853044 chr13:21883784 C/T cg06138931 chr13:21896616 NA 0.52 8.23 0.41 4.32e-15 Thiazide-induced adverse metabolic effects in hypertensive patients; CRC cis rs7586879 0.789 rs13382979 chr2:25131736 G/A cg22495460 chr2:25135724 ADCY3 -0.88 -14.62 -0.63 1.23e-37 Body mass index; CRC trans rs875971 0.660 rs2191268 chr7:66110224 C/T cg07581031 chr16:89898288 SPIRE2 0.39 6.39 0.33 5.6e-10 Aortic root size; CRC cis rs12926788 0.640 rs12924246 chr16:24844629 A/G cg02428538 chr16:24856791 SLC5A11 -0.57 -6.74 -0.35 6.91e-11 Ejection fraction in Tripanosoma cruzi seropositivity; CRC cis rs2739330 0.761 rs5760176 chr22:24402321 A/G cg11905131 chr22:24372483 LOC391322 0.6 9.38 0.46 1.14e-18 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs875971 0.862 rs778734 chr7:65814849 C/G cg11764359 chr7:65958608 NA 0.61 9.44 0.46 7.29e-19 Aortic root size; CRC trans rs2727020 0.729 rs685789 chr11:49241228 G/A cg15704280 chr7:45808275 SEPT13 0.86 14.4 0.62 8.63e-37 Coronary artery disease; CRC cis rs477895 0.838 rs35090903 chr11:64000598 C/T cg05016508 chr11:63871570 FLRT1;MACROD1 0.53 6.64 0.34 1.3e-10 Mean platelet volume; CRC cis rs4731207 0.662 rs2219954 chr7:124555855 T/C cg23710748 chr7:124431027 NA -0.38 -6.02 -0.32 4.57e-9 Cutaneous malignant melanoma; CRC cis rs10504229 0.679 rs7813252 chr8:58136389 C/G cg02290350 chr8:58132656 NA -0.58 -8.25 -0.41 3.77e-15 Developmental language disorder (linguistic errors); CRC cis rs2739330 0.760 rs5751760 chr22:24243573 G/A cg10150615 chr22:24372951 LOC391322 -0.58 -8.66 -0.43 2.16e-16 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs12142240 0.698 rs17361915 chr1:46847321 C/T cg00530320 chr1:46809349 NSUN4 0.59 8.07 0.41 1.35e-14 Menopause (age at onset); CRC cis rs7786808 0.552 rs896762 chr7:158182029 A/G cg01191920 chr7:158217561 PTPRN2 0.72 11.59 0.54 2.85e-26 Obesity-related traits; CRC cis rs2120019 1.000 rs12324912 chr15:75361006 G/A cg11632617 chr15:75315747 PPCDC -0.57 -8.05 -0.41 1.49e-14 Blood trace element (Zn levels); CRC trans rs916888 0.773 rs9896243 chr17:44826056 C/G cg22968622 chr17:43663579 NA 1.29 15.72 0.65 6.19e-42 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs12142240 0.738 rs10489769 chr1:46806703 A/G cg00530320 chr1:46809349 NSUN4 0.57 7.8 0.39 8.39e-14 Menopause (age at onset); CRC cis rs9308731 0.644 rs10189015 chr2:111918472 G/A cg18646521 chr2:111875858 NA 0.39 6.12 0.32 2.65e-9 Chronic lymphocytic leukemia; CRC trans rs7267979 1.000 rs2482919 chr20:25299756 T/C cg17903999 chr18:56338584 MALT1 0.43 6.85 0.35 3.73e-11 Liver enzyme levels (alkaline phosphatase); CRC cis rs7512552 0.839 rs2647373 chr1:150320570 G/C cg15654264 chr1:150340011 RPRD2 0.58 8.1 0.41 1.08e-14 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); CRC cis rs3820068 0.603 rs7537618 chr1:15977682 G/A cg13390004 chr1:15929781 NA 0.53 7.44 0.38 9.04e-13 Systolic blood pressure; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg05663655 chr7:107532014 DLD 0.44 6.11 0.32 2.74e-9 Response to antipsychotic treatment; CRC cis rs9916302 0.706 rs4795358 chr17:37573065 A/C cg15445000 chr17:37608096 MED1 0.36 6.27 0.33 1.14e-9 Glomerular filtration rate (creatinine); CRC cis rs2882667 0.858 rs13174479 chr5:138444170 G/A cg09476006 chr5:138032270 NA 0.44 6.78 0.35 5.62e-11 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs9916302 0.706 rs594794 chr17:37453485 T/C cg07936489 chr17:37558343 FBXL20 0.84 10.61 0.5 8.08e-23 Glomerular filtration rate (creatinine); CRC cis rs7651736 1.000 rs7651736 chr3:136760598 A/G cg21827317 chr3:136751795 NA 0.37 6.12 0.32 2.69e-9 Neuroticism; CRC cis rs710865 0.527 rs2275403 chr1:19557713 C/G cg13387374 chr1:19411106 UBR4 -0.57 -9.01 -0.44 1.69e-17 Brain structure; CRC cis rs10875746 0.951 rs4760690 chr12:48563653 G/A cg26205652 chr12:48591994 NA 0.46 5.61 0.3 4.33e-8 Longevity (90 years and older); CRC cis rs9287719 0.967 rs10203785 chr2:10752508 T/C cg00105475 chr2:10696890 NA 0.45 7.17 0.37 4.85e-12 Prostate cancer; CRC cis rs78456975 0.739 rs28913003 chr2:1519620 A/T cg12573674 chr2:1569213 NA -0.65 -7.58 -0.39 3.56e-13 Placebo response in major depressive disorder (% change in symptom score); CRC cis rs2120019 0.938 rs1867150 chr15:75321139 T/C cg17294928 chr15:75287854 SCAMP5 -0.77 -11.15 -0.52 1.03e-24 Blood trace element (Zn levels); CRC cis rs6502050 0.835 rs9904520 chr17:80100117 T/C cg22110888 chr17:80059540 CCDC57 0.4 6.44 0.33 4.17e-10 Life satisfaction; CRC cis rs10208940 0.920 rs35878577 chr2:68737456 C/T cg12452813 chr2:68675892 NA 0.49 6.01 0.31 5.03e-9 Urate levels in lean individuals; CRC cis rs1552244 0.882 rs34779351 chr3:10021801 A/G cg08888203 chr3:10149979 C3orf24 0.62 8.23 0.41 4.29e-15 Alzheimer's disease; CRC cis rs6952808 1.000 rs12540579 chr7:1882227 C/A cg21782813 chr7:2030301 MAD1L1 0.4 6.68 0.35 1e-10 Bipolar disorder and schizophrenia; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg00568128 chr10:115934100 MIR2110;C10orf118 0.45 6.1 0.32 2.91e-9 Response to antipsychotic treatment; CRC cis rs13098911 0.540 rs6790866 chr3:46074711 G/A cg12691230 chr3:46064611 XCR1 -0.52 -5.62 -0.3 4.01e-8 Celiac disease; CRC trans rs7395662 0.591 rs4882012 chr11:48560597 T/A cg21153622 chr11:89784906 NA -0.51 -8.48 -0.42 7.88e-16 HDL cholesterol; CRC cis rs6582630 0.537 rs12823925 chr12:38409323 C/T cg13010199 chr12:38710504 ALG10B 0.47 6.3 0.33 9.58e-10 Drug-induced liver injury (flucloxacillin); CRC cis rs769267 0.965 rs2017964 chr19:19387149 T/C cg02546618 chr19:19431379 KIAA0892;SF4 0.46 6.3 0.33 9.51e-10 Tonsillectomy; CRC cis rs8072100 0.967 rs12452315 chr17:45479446 G/T cg08085267 chr17:45401833 C17orf57 0.71 12.23 0.56 1.34e-28 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs9611565 0.512 rs45500192 chr22:42177899 A/G cg06481639 chr22:41940642 POLR3H -0.6 -6.6 -0.34 1.61e-10 Vitiligo; CRC cis rs3764563 1.000 rs623675 chr19:15705115 G/A cg20725493 chr19:15740067 CYP4F8 0.68 6.19 0.32 1.76e-9 Inflammatory biomarkers; CRC cis rs9612 1.000 rs2074634 chr19:44238347 C/T cg08581076 chr19:44259116 C19orf61 -0.48 -6.31 -0.33 9.24e-10 Exhaled nitric oxide output; CRC cis rs10256972 0.567 rs7782651 chr7:1159895 T/G cg23978390 chr7:1156363 C7orf50 0.55 7.45 0.38 8.54e-13 Longevity;Endometriosis; CRC cis rs11650494 0.908 rs118099826 chr17:47447836 G/T cg08112188 chr17:47440006 ZNF652 1.22 11.44 0.53 9.63e-26 Prostate cancer; CRC cis rs56307353 0.753 rs62129495 chr19:1962789 T/C cg26776924 chr19:1969666 CSNK1G2 0.45 7.22 0.37 3.69e-12 Coronary artery disease; CRC cis rs2245008 0.774 rs253136 chr16:83979601 A/C cg27171569 chr16:83987465 OSGIN1 -0.49 -8.37 -0.42 1.66e-15 Pursuit maintenance gain; CRC cis rs727505 1.000 rs113394869 chr7:124518172 G/C cg23710748 chr7:124431027 NA -0.8 -14.18 -0.62 6.24e-36 Lewy body disease; CRC trans rs11039798 0.623 rs6485879 chr11:48587984 G/T cg03929089 chr4:120376271 NA 0.67 7.14 0.37 6.18e-12 Axial length; CRC cis rs73110464 0.505 rs2638503 chr12:53307369 C/G cg14581129 chr12:53358946 NA -0.36 -5.62 -0.3 4.14e-8 Cancer (pleiotropy); CRC cis rs11969893 0.850 rs9404058 chr6:101323078 T/C cg12253828 chr6:101329408 ASCC3 1.16 9.51 0.46 4.23e-19 Economic and political preferences (immigration/crime); CRC cis rs916888 0.821 rs70600 chr17:44860021 C/T cg01570182 chr17:44337453 NA 1.15 13.53 0.6 1.84e-33 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs1448094 0.933 rs11836175 chr12:86311644 A/T cg18827107 chr12:86230957 RASSF9 -0.39 -6.38 -0.33 5.99e-10 Major depressive disorder; CRC cis rs728616 1.000 rs12768613 chr10:81916566 C/T cg11900509 chr10:81946545 ANXA11 -0.63 -7.58 -0.39 3.49e-13 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs10208940 0.843 rs7608248 chr2:68851403 C/T cg12452813 chr2:68675892 NA 0.49 6.1 0.32 2.97e-9 Urate levels in lean individuals; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg13482925 chr10:64028750 RTKN2 0.44 6.26 0.33 1.19e-9 Response to antipsychotic treatment; CRC cis rs617791 0.669 rs4994056 chr11:65750997 G/A cg26695010 chr11:65641043 EFEMP2 -0.4 -6.16 -0.32 2.14e-9 Breast cancer; CRC cis rs7949030 0.626 rs7943191 chr11:62328551 A/G cg22862634 chr11:62369728 EML3;MTA2 0.58 10.33 0.49 7.43e-22 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; CRC cis rs11122272 0.705 rs2808599 chr1:231533482 T/C cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.58 -8.61 -0.43 2.98e-16 Hemoglobin concentration; CRC trans rs2243480 1.000 rs7787230 chr7:65629099 G/A cg10756647 chr7:56101905 PSPH -0.76 -7.89 -0.4 4.47e-14 Diabetic kidney disease; CRC cis rs769267 0.930 rs3794993 chr19:19611550 G/T cg03709012 chr19:19516395 GATAD2A 0.71 11.06 0.52 2.23e-24 Tonsillectomy; CRC cis rs11997175 0.646 rs4612298 chr8:33713451 G/A cg04338863 chr8:33670619 NA 0.42 6.76 0.35 6.19e-11 Body mass index; CRC cis rs853679 0.517 rs3734573 chr6:28059437 T/C cg15786705 chr6:28176104 NA 0.76 9.63 0.47 1.68e-19 Depression; CRC trans rs1814175 0.754 rs10839453 chr11:49955815 A/T cg21153622 chr11:89784906 NA -0.37 -5.98 -0.31 5.84e-9 Height; CRC cis rs12983728 0.831 rs79222418 chr19:58664418 T/C cg12792011 chr19:58661915 ZNF329 0.71 7.72 0.39 1.37e-13 Cholesterol, total; CRC cis rs883565 0.569 rs1298712 chr3:39169693 A/G cg01426195 chr3:39028469 NA 0.39 6.39 0.33 5.57e-10 Handedness; CRC cis rs1003719 0.715 rs2156078 chr21:38546473 T/C cg10648535 chr21:38446584 PIGP;TTC3 -0.48 -6.72 -0.35 7.91e-11 Eye color traits; CRC cis rs28386778 0.897 rs2854208 chr17:61946885 C/T cg22520471 chr17:61851767 DDX42;CCDC47 0.73 11.22 0.53 5.75e-25 Prudent dietary pattern; CRC cis rs2242116 0.796 rs4683296 chr3:46973820 G/C cg02527881 chr3:46936655 PTH1R 0.49 8.87 0.44 4.69e-17 Birth weight; CRC cis rs4713118 0.662 rs9468277 chr6:28028390 C/A cg12273811 chr6:28175739 NA 0.62 8.22 0.41 4.78e-15 Parkinson's disease; CRC cis rs7412746 0.588 rs10305664 chr1:150839686 A/C cg18016565 chr1:150552671 MCL1 0.43 5.92 0.31 8.07e-9 Melanoma; CRC cis rs3806843 1.000 rs10477034 chr5:140169730 A/G cg16607685 chr5:140181889 PCDHA2;PCDHA1;PCDHA3 -0.26 -5.93 -0.31 7.83e-9 Depressive symptoms (multi-trait analysis); CRC cis rs11030122 0.592 rs4910880 chr11:4084630 C/G cg18678763 chr11:4115507 RRM1 -0.5 -8.08 -0.41 1.27e-14 Mean platelet volume;Platelet distribution width; CRC cis rs6662572 0.703 rs6689417 chr1:46388008 C/T cg08644498 chr1:46502608 NA -0.45 -7.08 -0.36 8.76e-12 Blood protein levels; CRC trans rs916888 0.773 rs199533 chr17:44828931 G/A cg22433210 chr17:43662623 NA 1.03 10.37 0.5 5.3e-22 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs1707322 0.752 rs10789467 chr1:46118745 C/G cg06784218 chr1:46089804 CCDC17 0.65 12.18 0.56 2.04e-28 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs9660992 0.508 rs113817010 chr1:205104581 C/A cg03948781 chr1:205179583 DSTYK 0.43 6.02 0.31 4.77e-9 Mean corpuscular volume;Mean platelet volume; CRC cis rs597539 0.690 rs578791 chr11:68625809 C/T cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.85 14.08 0.61 1.51e-35 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC trans rs8073060 0.586 rs7214742 chr17:33981969 C/A cg19694781 chr19:47549865 TMEM160 -1.05 -14.84 -0.63 1.67e-38 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; CRC cis rs3785574 0.962 rs2727329 chr17:61924566 C/T cg06601766 chr17:61851465 DDX42;CCDC47 0.58 8.08 0.41 1.26e-14 Height; CRC cis rs362272 0.545 rs2749783 chr4:3326098 A/C cg16416165 chr4:3325029 RGS12 0.39 5.9 0.31 9.06e-9 Serum sulfate level; CRC cis rs3749237 0.595 rs7643845 chr3:49530711 A/G cg02487422 chr3:49467188 NICN1 0.44 7.06 0.36 9.87e-12 Resting heart rate; CRC cis rs72781680 1.000 rs72796328 chr2:24141343 A/G cg08917208 chr2:24149416 ATAD2B 1.03 10.1 0.49 4.66e-21 Lymphocyte counts; CRC cis rs3806843 0.576 rs246059 chr5:140325010 G/T cg19875535 chr5:140030758 IK 0.39 6.02 0.31 4.67e-9 Depressive symptoms (multi-trait analysis); CRC cis rs34172651 0.517 rs200526 chr16:24760511 C/T cg02428538 chr16:24856791 SLC5A11 0.56 6.66 0.34 1.18e-10 Intelligence (multi-trait analysis); CRC cis rs216303 0.642 rs216315 chr12:6136914 A/G cg19878637 chr12:6148451 VWF -0.61 -6.82 -0.35 4.34e-11 Low vWF levels; CRC cis rs9527 0.535 rs4917999 chr10:104963051 C/G cg04362960 chr10:104952993 NT5C2 -0.63 -8.86 -0.44 5.11e-17 Arsenic metabolism; CRC cis rs7493 0.853 rs35686517 chr7:95052611 G/A cg17330251 chr7:94953956 PON1 -0.6 -7.49 -0.38 6.26e-13 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs7917772 0.582 rs4408249 chr10:104374653 T/A cg11453585 chr10:104263688 ACTR1A;SUFU 0.81 14.65 0.63 9.36e-38 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC cis rs9435341 1.000 rs1762484 chr1:107613923 A/C cg11070056 chr1:107600091 PRMT6 -0.4 -5.74 -0.3 2.19e-8 Facial morphology (factor 21, depth of nasal alae); CRC cis rs9768139 0.733 rs71545585 chr7:158118672 G/A cg24154853 chr7:158122151 PTPRN2 0.61 9.99 0.48 1.09e-20 Calcium levels; CRC cis rs769267 0.930 rs6511038 chr19:19607564 A/C cg01262667 chr19:19385393 TM6SF2 0.36 5.87 0.31 1.06e-8 Tonsillectomy; CRC cis rs9322193 0.923 rs10872649 chr6:150080590 T/G cg07701084 chr6:150067640 NUP43 0.59 8.71 0.43 1.48e-16 Lung cancer; CRC cis rs9837602 1.000 rs6802422 chr3:99778655 C/T cg07805332 chr3:99536008 MIR548G;C3orf26 0.48 6.33 0.33 8.23e-10 Breast cancer; CRC cis rs440932 1.000 rs365309 chr8:9026940 C/T cg08975724 chr8:8085496 FLJ10661 -0.39 -5.68 -0.3 3.03e-8 High light scatter reticulocyte percentage of red cells; CRC cis rs6674176 0.660 rs11210936 chr1:44391438 A/T cg13606994 chr1:44402422 ARTN -0.38 -6.4 -0.33 5.28e-10 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Cognitive ability; CRC cis rs62432291 0.681 rs378339 chr6:159658852 C/T cg14500486 chr6:159655392 FNDC1 -0.77 -10.43 -0.5 3.48e-22 Joint mobility (Beighton score); CRC cis rs1178968 0.818 rs2528709 chr7:72788457 C/A cg25889504 chr7:72793014 NA 0.49 5.63 0.3 3.81e-8 Triglyceride levels; CRC cis rs539514 0.550 rs2328956 chr13:76294595 G/A cg04757411 chr13:76259545 LMO7 -0.35 -5.96 -0.31 6.55e-9 Type 1 diabetes; CRC cis rs12586317 0.547 rs77780729 chr14:35496176 C/A cg16230307 chr14:35515116 FAM177A1 0.9 10.5 0.5 1.98e-22 Psoriasis; CRC cis rs28386778 0.897 rs8069969 chr17:61822223 T/G cg25654072 chr17:61904446 PSMC5;FTSJ3 0.71 11.13 0.52 1.23e-24 Prudent dietary pattern; CRC cis rs1472147 1.000 rs3736609 chr7:128509319 G/A cg00260937 chr7:128520193 KCP 0.47 7.11 0.36 7.43e-12 Calcium levels; CRC cis rs919433 0.783 rs55725278 chr2:198238223 C/T cg03934865 chr2:198174659 NA 0.36 5.81 0.31 1.44e-8 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC cis rs7726839 0.561 rs72703046 chr5:580129 T/C cg14541582 chr5:601475 NA -0.32 -6.61 -0.34 1.57e-10 Obesity-related traits; CRC cis rs7224685 0.501 rs4790168 chr17:4022457 T/C cg05562828 chr17:3906858 NA -0.67 -11.81 -0.55 4.59e-27 Type 2 diabetes; CRC cis rs9549367 0.756 rs2316463 chr13:113901406 C/T cg18105134 chr13:113819100 PROZ -0.75 -10.65 -0.51 5.74e-23 Platelet distribution width; CRC cis rs7216064 1.000 rs56393562 chr17:65933918 C/T cg12091567 chr17:66097778 LOC651250 -0.61 -7.18 -0.37 4.74e-12 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CRC trans rs7580658 0.614 rs7585198 chr2:127962635 C/T cg26322434 chr3:61237156 FHIT -0.46 -6.31 -0.33 9.27e-10 Protein C levels; CRC cis rs644799 0.965 rs598876 chr11:95560853 A/G cg25622487 chr11:95524042 FAM76B;CEP57 0.76 11.99 0.55 9.59e-28 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC trans rs1899951 1.000 rs4684848 chr3:12395645 G/A cg04083076 chr1:169452126 SLC19A2 -0.47 -6.09 -0.32 3.17e-9 Body mass index; CRC cis rs6500602 0.674 rs7191664 chr16:4541924 T/C cg08645402 chr16:4508243 NA 0.57 8.6 0.43 3.4e-16 Schizophrenia; CRC cis rs4481887 0.927 rs4551626 chr1:248489128 G/T cg13385794 chr1:248469461 NA 0.38 6.66 0.34 1.14e-10 Common traits (Other); CRC cis rs873946 0.586 rs3829130 chr10:134563122 C/T cg06453172 chr10:134556979 INPP5A -0.68 -8.14 -0.41 8.53e-15 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CRC cis rs4969178 0.965 rs2292643 chr17:76395421 G/A cg05887092 chr17:76393375 PGS1 0.56 10.13 0.49 3.7e-21 HDL cholesterol levels; CRC cis rs2075371 1.000 rs1421484 chr7:133979795 T/C cg11752832 chr7:134001865 SLC35B4 0.49 7.5 0.38 6.03e-13 Mean platelet volume; CRC cis rs5769765 0.908 rs9616390 chr22:50314289 G/C cg02269571 chr22:50332266 NA -0.61 -7.92 -0.4 3.68e-14 Schizophrenia; CRC cis rs7503807 0.967 rs8064502 chr17:78562434 C/A cg09596252 chr17:78655493 RPTOR 0.39 5.92 0.31 8.14e-9 Obesity; CRC cis rs6424115 0.743 rs2229580 chr1:24201109 C/T cg15997130 chr1:24165203 NA 0.73 10.74 0.51 2.79e-23 Immature fraction of reticulocytes; CRC cis rs34375054 0.525 rs7133006 chr12:125606123 G/A cg25124228 chr12:125621409 AACS -0.67 -10.86 -0.51 1.13e-23 Post bronchodilator FEV1/FVC ratio; CRC trans rs7267979 0.903 rs6050482 chr20:25226327 C/T cg17903999 chr18:56338584 MALT1 -0.41 -6.54 -0.34 2.39e-10 Liver enzyme levels (alkaline phosphatase); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg07192240 chr11:3829780 PGAP2 0.35 6.02 0.31 4.63e-9 Liver disease severity in Alagille syndrome; CRC trans rs7267979 1.000 rs7019 chr20:25278278 C/T cg17903999 chr18:56338584 MALT1 -0.43 -7.07 -0.36 9.06e-12 Liver enzyme levels (alkaline phosphatase); CRC cis rs863345 0.604 rs10908661 chr1:158466990 T/A cg12129480 chr1:158549410 OR10X1 -0.29 -6.21 -0.32 1.61e-9 Pneumococcal bacteremia; CRC cis rs4363385 0.693 rs6668311 chr1:152964586 A/G cg25856811 chr1:152973957 SPRR3 -0.26 -7.32 -0.37 1.97e-12 Inflammatory skin disease; CRC cis rs1975974 0.872 rs66502681 chr17:21722119 T/A cg18423549 chr17:21743878 NA -0.65 -8.89 -0.44 4.18e-17 Psoriasis; CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg20149956 chr1:249132233 ZNF672 0.39 6.13 0.32 2.5e-9 Obesity-related traits; CRC cis rs7177699 0.557 rs11072807 chr15:79111517 A/G cg15571903 chr15:79123663 NA 0.31 6.1 0.32 3.05e-9 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; CRC cis rs10256972 0.504 rs2949178 chr7:1209925 T/C cg03923535 chr7:1197113 ZFAND2A 0.71 10.73 0.51 3.25e-23 Longevity;Endometriosis; CRC cis rs11212617 0.967 rs6589019 chr11:108324961 T/C cg01991180 chr11:108092276 ATM;NPAT 0.41 5.9 0.31 9.28e-9 Response to metformin in type 2 diabetes (glycemic); CRC cis rs1552244 1.000 rs67134728 chr3:10151431 G/C cg00166722 chr3:10149974 C3orf24 0.7 9.21 0.45 3.89e-18 Alzheimer's disease; CRC cis rs6502050 0.769 rs9898292 chr17:80100345 A/T cg22110888 chr17:80059540 CCDC57 0.4 6.44 0.33 4.17e-10 Life satisfaction; CRC cis rs8180040 0.966 rs11711824 chr3:47468261 C/T cg27129171 chr3:47204927 SETD2 0.52 8.05 0.41 1.58e-14 Colorectal cancer; CRC cis rs997295 0.535 rs11630854 chr15:67858116 A/T cg24247231 chr15:67904302 MAP2K5 -0.35 -6.14 -0.32 2.4e-9 Motion sickness; CRC cis rs1609391 0.561 rs6439675 chr3:136625436 G/A cg15507776 chr3:136538369 TMEM22 0.34 6.21 0.32 1.61e-9 Neuroticism; CRC cis rs912057 0.932 rs1294406 chr6:6737737 A/G cg06612196 chr6:6737390 NA 0.57 9.36 0.46 1.25e-18 Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction); CRC cis rs9616064 0.506 rs2073275 chr22:47070432 G/C cg05621596 chr22:47072043 GRAMD4 -0.82 -13.96 -0.61 4.04e-35 Urate levels in obese individuals; CRC cis rs9611565 0.765 rs9607800 chr22:41784562 A/G cg06481639 chr22:41940642 POLR3H -0.52 -6.04 -0.32 4.2e-9 Vitiligo; CRC cis rs9649213 0.613 rs2286074 chr7:97952011 G/A cg08684580 chr7:98029266 BAIAP2L1 -0.31 -5.62 -0.3 4.03e-8 Prostate cancer (SNP x SNP interaction); CRC trans rs2303319 0.504 rs56965753 chr2:162597251 A/G cg23247704 chr1:116518985 SLC22A15 -0.72 -6.14 -0.32 2.42e-9 Cognitive function; CRC cis rs6951245 0.554 rs58210047 chr7:1149381 G/A cg26224354 chr7:1096374 C7orf50;GPR146 -0.64 -8.54 -0.43 5.02e-16 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs12190007 0.547 rs1018559 chr6:169854176 A/G cg15038512 chr6:170123185 PHF10 -0.37 -5.75 -0.3 2.01e-8 Obesity-related traits; CRC cis rs1552244 1.000 rs6442146 chr3:10073544 C/T cg10729496 chr3:10149963 C3orf24 0.5 6.72 0.35 7.88e-11 Alzheimer's disease; CRC cis rs1707322 0.721 rs10789468 chr1:46124558 A/G cg03146154 chr1:46216737 IPP 0.66 9.71 0.47 8.86e-20 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs35146811 0.735 rs858512 chr7:99824453 A/G cg00553149 chr7:99775558 STAG3;GPC2 -0.25 -5.74 -0.3 2.16e-8 Coronary artery disease; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg12753518 chr1:28414763 EYA3 0.49 6.55 0.34 2.15e-10 Thyroid stimulating hormone; CRC cis rs10504229 1.000 rs1961778 chr8:58168756 G/A cg01721255 chr8:58191610 C8orf71 0.45 5.76 0.3 1.96e-8 Developmental language disorder (linguistic errors); CRC cis rs11628318 0.715 rs1815262 chr14:103056926 C/T cg12046867 chr14:103022105 NA -0.79 -9.13 -0.45 7.13e-18 Platelet count; CRC cis rs2842992 0.830 rs2758352 chr6:160122921 A/G cg19482086 chr6:160211437 TCP1;MRPL18 0.69 8.55 0.43 4.63e-16 Age-related macular degeneration (geographic atrophy); CRC cis rs2032447 0.832 rs10425 chr6:26056549 A/G cg03264133 chr6:25882463 NA -0.46 -6.38 -0.33 6.03e-10 Intelligence (multi-trait analysis); CRC cis rs6952808 0.564 rs55865401 chr7:2145720 G/C cg02951883 chr7:2050386 MAD1L1 -0.69 -11.07 -0.52 2.08e-24 Bipolar disorder and schizophrenia; CRC cis rs2576037 0.899 rs2576035 chr18:44587654 C/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 -0.47 -7.38 -0.38 1.31e-12 Personality dimensions; CRC cis rs9372498 0.505 rs17080456 chr6:118985938 G/C cg07617317 chr6:118971624 C6orf204 0.49 5.86 0.31 1.11e-8 Diastolic blood pressure; CRC cis rs7726839 0.540 rs72703083 chr5:595365 C/T cg14541582 chr5:601475 NA -0.36 -7.37 -0.38 1.42e-12 Obesity-related traits; CRC cis rs8040855 0.627 rs2304418 chr15:85640983 T/C cg10818794 chr15:86012489 AKAP13 -0.42 -5.65 -0.3 3.4e-8 Bulimia nervosa; CRC cis rs2153535 0.580 rs7742794 chr6:8459723 C/A cg21535247 chr6:8435926 SLC35B3 0.51 7.9 0.4 4.36e-14 Motion sickness; CRC cis rs6598955 0.671 rs8564 chr1:26605069 T/C cg04990556 chr1:26633338 UBXN11 0.53 5.73 0.3 2.23e-8 Obesity-related traits; CRC cis rs7614311 0.731 rs56263032 chr3:63863022 G/A cg22134162 chr3:63841271 THOC7 -0.58 -6.04 -0.32 4.28e-9 Lung function (FVC);Lung function (FEV1); CRC cis rs10982256 0.870 rs10982247 chr9:117250792 C/T cg13636371 chr9:117264095 DFNB31 -0.34 -6.57 -0.34 1.92e-10 Bipolar disorder; CRC cis rs7674212 0.541 rs4699051 chr4:104114394 T/C cg16532752 chr4:104119610 CENPE -0.41 -5.76 -0.3 1.91e-8 Type 2 diabetes; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg24276841 chr17:4125562 ANKFY1 0.41 6.27 0.33 1.11e-9 Intelligence (multi-trait analysis); CRC cis rs4654899 0.758 rs6702331 chr1:21516107 A/T cg02927042 chr1:21476669 EIF4G3 -0.4 -6.41 -0.33 5.06e-10 Superior frontal gyrus grey matter volume; CRC cis rs12824058 0.831 rs7299065 chr12:130809661 A/T cg26677194 chr12:130822605 PIWIL1 0.45 7.19 0.37 4.42e-12 Menopause (age at onset); CRC cis rs2153535 0.580 rs6926759 chr6:8456176 G/A cg07606381 chr6:8435919 SLC35B3 0.67 10.72 0.51 3.51e-23 Motion sickness; CRC cis rs12824058 0.831 rs12831363 chr12:130814013 C/T cg24838063 chr12:130822603 PIWIL1 -0.57 -9.6 -0.47 2.15e-19 Menopause (age at onset); CRC cis rs1215050 0.791 rs165241 chr4:98681112 C/T cg05340658 chr4:99064831 C4orf37 0.47 7.01 0.36 1.4e-11 Waist-to-hip ratio adjusted for body mass index; CRC trans rs2018683 0.707 rs4722877 chr7:28972906 A/G cg19402173 chr7:128379420 CALU -0.42 -6.13 -0.32 2.56e-9 Response to irinotecan and platinum-based chemotherapy in non-small-cell lung cancer; CRC cis rs651907 0.535 rs11717638 chr3:101505468 A/G cg11279151 chr3:101281821 RG9MTD1 -0.52 -7.05 -0.36 1.07e-11 Colorectal cancer; CRC cis rs7914558 0.966 rs10748835 chr10:104660256 C/T cg11453585 chr10:104263688 ACTR1A;SUFU -0.38 -5.61 -0.3 4.24e-8 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC trans rs7615952 0.546 rs4428131 chr3:125346479 C/T cg21747405 chr11:67723411 NA -0.49 -6.25 -0.33 1.26e-9 Blood pressure (smoking interaction); CRC cis rs3772130 0.564 rs35178434 chr3:121595936 G/A cg20356878 chr3:121714668 ILDR1 0.56 10.75 0.51 2.57e-23 Cognitive performance; CRC cis rs7726839 0.718 rs6887972 chr5:597274 C/G cg09021430 chr5:549028 NA -0.62 -8.35 -0.42 1.86e-15 Obesity-related traits; CRC cis rs9818758 0.556 rs73077200 chr3:49826987 C/T cg00383909 chr3:49044727 WDR6 1.37 10.99 0.52 3.88e-24 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; CRC cis rs9611565 0.659 rs73178632 chr22:41934573 C/T cg06634786 chr22:41940651 POLR3H -0.7 -8.13 -0.41 8.97e-15 Vitiligo; CRC cis rs7584330 0.554 rs6740834 chr2:238423442 T/C cg16989719 chr2:238392110 NA -0.35 -5.64 -0.3 3.6e-8 Prostate cancer; CRC trans rs61931739 0.500 rs7313094 chr12:34457508 T/C cg26384229 chr12:38710491 ALG10B 0.62 9.03 0.45 1.52e-17 Morning vs. evening chronotype; CRC cis rs11031096 0.727 rs2268168 chr11:4142069 C/T cg18678763 chr11:4115507 RRM1 -0.52 -8.64 -0.43 2.49e-16 Mean corpuscular volume;Mean corpuscular hemoglobin; CRC trans rs800082 0.675 rs2117004 chr3:144180576 G/A cg24215973 chr2:240111563 HDAC4 0.45 6.46 0.34 3.86e-10 Smoking behavior; CRC cis rs11190604 0.943 rs11190574 chr10:102234331 T/C cg16342193 chr10:102329863 NA -0.37 -5.96 -0.31 6.42e-9 Palmitoleic acid (16:1n-7) levels; CRC cis rs7937682 0.632 rs1045282 chr11:111754574 A/C cg09085632 chr11:111637200 PPP2R1B 0.95 15.06 0.64 2.3e-39 Primary sclerosing cholangitis; CRC cis rs4594175 0.926 rs66625118 chr14:51631062 T/C cg23942311 chr14:51606299 NA 0.63 10.39 0.5 4.86e-22 Cancer; CRC cis rs1018836 0.828 rs7816023 chr8:91567398 T/C cg16814680 chr8:91681699 NA -0.63 -9.84 -0.48 3.47e-20 Ejection fraction in Tripanosoma cruzi seropositivity; CRC cis rs7122539 0.646 rs682842 chr11:66568943 A/G cg24851651 chr11:66362959 CCS -0.51 -9.81 -0.48 4.18e-20 HIV-1 susceptibility; CRC trans rs6561151 0.645 rs61959960 chr13:44439265 T/G cg17145862 chr1:211918768 LPGAT1 0.49 6.31 0.33 8.95e-10 Crohn's disease; CRC cis rs7945705 0.902 rs10769980 chr11:9014180 G/A cg21881798 chr11:8931708 C11orf17;ST5 0.63 9.69 0.47 1.09e-19 Hemoglobin concentration; CRC cis rs7465272 1.000 rs7465272 chr8:143691838 A/T cg19438565 chr8:143695827 ARC -0.48 -6.63 -0.34 1.41e-10 Bipolar disorder and schizophrenia; CRC cis rs3796352 0.881 rs11710394 chr3:53015839 A/G cg27565382 chr3:53032988 SFMBT1 0.65 5.68 0.3 2.94e-8 Immune reponse to smallpox (secreted IL-2); CRC cis rs1799949 0.896 rs33933393 chr17:41317432 C/T cg25072359 chr17:41440525 NA 0.46 6.98 0.36 1.67e-11 Menopause (age at onset); CRC cis rs875971 1.000 rs6945843 chr7:65734783 G/A cg12463550 chr7:65579703 CRCP -0.46 -6.63 -0.34 1.38e-10 Aortic root size; CRC cis rs4665809 1.000 rs2289022 chr2:26350136 G/T cg25036284 chr2:26402008 FAM59B -0.46 -5.97 -0.31 6e-9 Gut microbiome composition (summer); CRC cis rs601339 0.877 rs2649991 chr12:123179461 A/G cg22192744 chr12:123187474 GPR109A -0.4 -5.66 -0.3 3.25e-8 Adiponectin levels; CRC cis rs28386778 0.863 rs2584637 chr17:61942952 T/C cg23090583 chr17:61904693 PSMC5;FTSJ3 1.04 19.8 0.74 5.09e-58 Prudent dietary pattern; CRC cis rs35995292 0.534 rs11980627 chr7:38907533 T/C cg19327137 chr7:38886074 VPS41 0.69 11.63 0.54 2.09e-26 Subjective well-being (multi-trait analysis); CRC cis rs2976388 0.609 rs2257796 chr8:143808667 T/C cg12516270 chr8:143859308 LYNX1 0.44 7.65 0.39 2.28e-13 Urinary tract infection frequency; CRC cis rs17065868 0.764 rs9533863 chr13:45036780 G/A cg10246903 chr13:45222710 NA 0.54 5.69 0.3 2.79e-8 Antineutrophil cytoplasmic antibody-associated vasculitis; CRC cis rs6860806 0.507 rs272878 chr5:131671769 C/T cg09877947 chr5:131593287 PDLIM4 -0.44 -7.39 -0.38 1.25e-12 Breast cancer; CRC cis rs7552404 0.960 rs4949877 chr1:76201668 C/G cg10523679 chr1:76189770 ACADM 0.83 11.32 0.53 2.68e-25 Blood metabolite levels;Acylcarnitine levels; CRC cis rs10504229 0.683 rs882429 chr8:58129292 A/G cg02725872 chr8:58115012 NA -0.64 -11.55 -0.54 3.85e-26 Developmental language disorder (linguistic errors); CRC cis rs8014671 0.567 rs6573971 chr14:71011469 C/T cg25576086 chr14:70833871 SYNJ2BP 0.36 6.1 0.32 2.97e-9 Prostate cancer; CRC cis rs9649213 0.574 rs3801251 chr7:98027618 T/C cg24562669 chr7:97807699 LMTK2 0.43 7.06 0.36 1.01e-11 Prostate cancer (SNP x SNP interaction); CRC cis rs7103648 0.643 rs12365079 chr11:47696596 A/T cg20307385 chr11:47447363 PSMC3 0.77 10.83 0.51 1.37e-23 Diastolic blood pressure;Systolic blood pressure; CRC cis rs868943 0.743 rs13213124 chr6:116335637 A/G cg26893134 chr6:116381904 FRK 0.26 6.43 0.33 4.61e-10 Total cholesterol levels; CRC cis rs12325245 0.536 rs12709002 chr16:58614337 A/C cg02549819 chr16:58548995 SETD6 1.11 7.23 0.37 3.5e-12 Schizophrenia; CRC cis rs9916302 0.821 rs12938268 chr17:37572139 G/A cg15445000 chr17:37608096 MED1 0.42 9.14 0.45 6.65e-18 Glomerular filtration rate (creatinine); CRC trans rs9341835 0.740 rs10755410 chr6:64150689 G/A cg13657004 chr13:50234944 EBPL -0.36 -6.08 -0.32 3.38e-9 Schizophrenia; CRC cis rs1881797 0.527 rs79724455 chr1:247646957 T/C cg05639522 chr1:247681581 NA 0.56 6.05 0.32 3.95e-9 Acute lymphoblastic leukemia (childhood); CRC cis rs9457247 1.000 rs408918 chr6:167399282 G/T cg23791538 chr6:167370224 RNASET2 -0.37 -5.78 -0.3 1.74e-8 Crohn's disease; CRC cis rs1729951 0.575 rs16844362 chr3:136704008 T/C cg21827317 chr3:136751795 NA 0.36 5.87 0.31 1.05e-8 Neuroticism; CRC cis rs9296092 0.538 rs75501442 chr6:33519493 A/G cg13560919 chr6:33536144 NA -0.45 -6.28 -0.33 1.07e-9 Age at smoking initiation in chronic obstructive pulmonary disease; CRC cis rs7621025 0.500 rs1965107 chr3:136648643 T/A cg15507776 chr3:136538369 TMEM22 0.44 6.81 0.35 4.61e-11 C-reactive protein levels or HDL-cholesterol levels (pleiotropy);Body mass index; CRC cis rs473651 0.935 rs515412 chr2:239345394 A/T cg21699342 chr2:239360505 ASB1 0.6 10.88 0.51 9.33e-24 Multiple system atrophy; CRC cis rs2019137 0.836 rs4848318 chr2:113953952 T/C cg21482265 chr2:113992762 PAX8;LOC440839;LOC654433 -0.48 -6.77 -0.35 5.81e-11 Lymphocyte counts; CRC trans rs2727020 0.718 rs1404366 chr11:49415899 T/A cg15704280 chr7:45808275 SEPT13 -0.81 -11.5 -0.54 6.09e-26 Coronary artery disease; CRC cis rs12024301 0.557 rs12038024 chr1:183603907 T/C cg11505048 chr1:183622726 RGL1;APOBEC4 0.75 6.81 0.35 4.6e-11 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs2243480 1.000 rs4718333 chr7:65772758 T/C cg18252515 chr7:66147081 NA 1.27 14.75 0.63 3.81e-38 Diabetic kidney disease; CRC trans rs35110281 0.776 rs9306159 chr21:45061839 G/T cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.51 8.76 0.43 1.06e-16 Mean corpuscular volume; CRC cis rs7707921 0.801 rs862243 chr5:81586829 C/G cg07807695 chr5:81608485 ATP6AP1L -0.47 -7.4 -0.38 1.14e-12 Breast cancer; CRC cis rs11758351 0.518 rs78871852 chr6:26221566 A/T cg01420254 chr6:26195488 NA 0.75 8.48 0.42 7.58e-16 Gout;Renal underexcretion gout; CRC cis rs806215 1.000 rs806219 chr7:127240094 A/C cg25922125 chr7:127225783 GCC1 0.56 6.33 0.33 7.8e-10 Type 2 diabetes; CRC cis rs8180040 0.629 rs7426969 chr3:47091355 T/C cg02527881 chr3:46936655 PTH1R -0.34 -5.96 -0.31 6.66e-9 Colorectal cancer; CRC cis rs965469 0.895 rs12626130 chr20:3393192 G/T cg25506879 chr20:3388711 C20orf194 -0.39 -5.67 -0.3 3.16e-8 IFN-related cytopenia; CRC cis rs897984 0.542 rs6565217 chr16:31083324 C/T cg00531865 chr16:30841666 NA -0.43 -6.32 -0.33 8.3e-10 Dementia with Lewy bodies; CRC cis rs6502050 0.835 rs9900128 chr17:80087920 A/T cg09264619 chr17:80180166 NA -0.36 -6.09 -0.32 3.09e-9 Life satisfaction; CRC cis rs9916302 0.706 rs11657153 chr17:37699729 A/G cg15445000 chr17:37608096 MED1 0.35 6.24 0.33 1.34e-9 Glomerular filtration rate (creatinine); CRC cis rs2386661 0.547 rs4747358 chr10:5650193 A/G cg12223502 chr10:5658492 NA 0.41 6.49 0.34 3.1e-10 Breast cancer; CRC cis rs6714710 0.603 rs55776387 chr2:98405034 T/C cg26665480 chr2:98280029 ACTR1B 0.53 7.25 0.37 3.04e-12 Posterior cortical atrophy and Alzheimer's disease; CRC cis rs10089 0.953 rs72794400 chr5:127516028 C/G cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.71 9.79 0.47 5.02e-20 Ileal carcinoids; CRC cis rs7589728 1.000 rs75309929 chr2:88524377 T/C cg24977027 chr2:88469347 THNSL2 0.56 6.62 0.34 1.47e-10 Plasma clusterin levels; CRC cis rs10256972 0.616 rs6957733 chr7:1106327 T/G cg03923535 chr7:1197113 ZFAND2A 0.51 7.51 0.38 5.77e-13 Longevity;Endometriosis; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg08023020 chr16:2059559 ZNF598 0.47 6.52 0.34 2.66e-10 Anxiety disorder; CRC cis rs2976388 0.609 rs2244152 chr8:143784885 C/A cg05569086 chr8:143859399 LYNX1 0.4 6.85 0.35 3.6e-11 Urinary tract infection frequency; CRC cis rs9858542 0.953 rs12330269 chr3:49513910 G/A cg07274523 chr3:49395745 GPX1 0.47 6.4 0.33 5.33e-10 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs9517320 0.534 rs3858776 chr13:99161457 C/T cg20487152 chr13:99095054 FARP1 -0.48 -7.25 -0.37 2.92e-12 Longevity; CRC cis rs8062405 0.756 rs151301 chr16:28497059 T/A cg16576597 chr16:28551801 NUPR1 0.48 6.61 0.34 1.56e-10 Cognitive ability (multi-trait analysis);Cognitive ability; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg01956147 chr2:17935879 GEN1;SMC6 -0.39 -6.04 -0.32 4.23e-9 Myopia (pathological); CRC cis rs10208940 0.764 rs6741037 chr2:68787042 C/T cg12452813 chr2:68675892 NA 0.47 5.93 0.31 7.57e-9 Urate levels in lean individuals; CRC cis rs1182196 0.502 rs757786 chr7:2836019 C/T cg13628971 chr7:2884303 GNA12 0.37 5.72 0.3 2.35e-8 Plateletcrit; CRC cis rs11148252 0.875 rs9596651 chr13:52938582 A/G cg00495681 chr13:53174319 NA -0.53 -8.13 -0.41 9e-15 Lewy body disease; CRC cis rs7618915 0.501 rs2336146 chr3:52626646 A/G cg11645453 chr3:52864694 ITIH4 0.36 6.48 0.34 3.43e-10 Bipolar disorder; CRC cis rs9807989 0.507 rs2041739 chr2:102994333 A/G cg03938978 chr2:103052716 IL18RAP -0.58 -10.01 -0.48 9.4499999999999992e-21 Asthma; CRC cis rs11958404 0.932 rs60504573 chr5:157436786 T/A cg05962755 chr5:157440814 NA 0.95 12.34 0.56 5.17e-29 IgG glycosylation; CRC cis rs1707322 1.000 rs4489497 chr1:46438698 C/T cg06784218 chr1:46089804 CCDC17 0.51 8.96 0.44 2.39e-17 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs929596 0.785 rs17862875 chr2:234649302 G/A cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.73 -10.74 -0.51 2.87e-23 Total bilirubin levels in HIV-1 infection; CRC cis rs644799 0.542 rs10831417 chr11:95467262 A/G cg25622487 chr11:95524042 FAM76B;CEP57 -0.49 -6.88 -0.35 3.02e-11 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs9372498 0.536 rs2356501 chr6:118942371 C/A cg15382696 chr6:118971807 C6orf204 0.6 7.57 0.39 3.76e-13 Diastolic blood pressure; CRC cis rs1448094 0.511 rs61930582 chr12:86157387 T/C cg02569458 chr12:86230093 RASSF9 0.51 8.43 0.42 1.13e-15 Major depressive disorder; CRC cis rs7727544 0.507 rs10051679 chr5:131570931 T/A cg11843238 chr5:131593191 PDLIM4 0.48 8.88 0.44 4.47e-17 Blood metabolite levels; CRC cis rs699 0.556 rs2478517 chr1:230867887 A/G cg07502417 chr1:230849801 AGT 0.29 5.76 0.3 1.93e-8 Coronary artery disease; CRC cis rs28386778 0.897 rs2236736 chr17:61938248 G/T cg25654072 chr17:61904446 PSMC5;FTSJ3 0.69 10.67 0.51 4.87e-23 Prudent dietary pattern; CRC cis rs6426558 0.502 rs2813970 chr1:227410637 C/T cg10327440 chr1:227177885 CDC42BPA 0.43 6.43 0.33 4.44e-10 Neutrophil percentage of white cells; CRC trans rs11764590 0.694 rs7801349 chr7:2085553 T/C cg11693508 chr17:37793320 STARD3 0.45 6.1 0.32 2.92e-9 Neuroticism; CRC cis rs2204008 0.521 rs7311188 chr12:38542813 C/G cg13010199 chr12:38710504 ALG10B -0.42 -6.07 -0.32 3.55e-9 Bladder cancer; CRC cis rs1059312 0.808 rs12831705 chr12:129294905 G/A cg21616243 chr12:129299702 MGC16384;SLC15A4 -0.76 -13.38 -0.59 6.59e-33 Systemic lupus erythematosus; CRC cis rs3812762 0.701 rs4929915 chr11:8824418 A/C cg14711859 chr11:8959438 ASCL3 0.45 6.64 0.34 1.34e-10 Hypospadias; CRC cis rs909002 0.800 rs2176807 chr1:32092735 T/G cg01639898 chr1:32083012 HCRTR1 0.31 6.41 0.33 4.95e-10 Intelligence (multi-trait analysis); CRC cis rs13191362 1.000 rs13204439 chr6:163015358 A/C cg06582575 chr6:163149167 PACRG;PARK2 -0.7 -9.88 -0.48 2.51e-20 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs2180341 0.782 rs6924274 chr6:127721556 T/A cg27446573 chr6:127587934 RNF146 0.72 10.03 0.48 7.74e-21 Breast cancer; CRC cis rs7762018 0.769 rs74838157 chr6:170077323 G/A cg19338460 chr6:170058176 WDR27 -0.96 -9.69 -0.47 1.04e-19 Thiazide-induced adverse metabolic effects in hypertensive patients; CRC cis rs3789045 0.707 rs61421373 chr1:204560440 C/T cg17419461 chr1:204415978 PIK3C2B -0.5 -7.14 -0.37 6.08e-12 Educational attainment (college completion); CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg02034563 chr2:179060011 OSBPL6 -0.5 -6.36 -0.33 6.76e-10 Diisocyanate-induced asthma; CRC cis rs11997175 0.583 rs7460295 chr8:33812288 C/T cg04338863 chr8:33670619 NA 0.44 6.55 0.34 2.28e-10 Body mass index; CRC cis rs3796352 1.000 rs35163227 chr3:53127876 A/G cg07884673 chr3:53033167 SFMBT1 0.75 5.99 0.31 5.41e-9 Immune reponse to smallpox (secreted IL-2); CRC trans rs12663356 0.528 rs9350359 chr6:21462624 C/T cg09488452 chr16:14723959 PARN 0.4 5.97 0.31 6.18e-9 Crohn's disease; CRC trans rs3960554 1.000 rs2079477 chr7:75836549 C/G cg19862616 chr7:65841803 NCRNA00174 0.64 7.8 0.4 8.03e-14 Eotaxin levels; CRC cis rs12630931 1.000 rs11714698 chr3:31971524 G/T cg21375017 chr3:31988082 OSBPL10 0.43 5.89 0.31 9.53e-9 Periodontal disease-related phenotypes; CRC cis rs11608355 0.515 rs4766606 chr12:109934390 C/G cg05360138 chr12:110035743 NA 0.76 8.5 0.42 6.78e-16 Neuroticism; CRC trans rs2727020 0.704 rs2988340 chr11:49176057 C/T cg15704280 chr7:45808275 SEPT13 -0.75 -11.91 -0.55 2.01e-27 Coronary artery disease; CRC cis rs427941 0.669 rs417013 chr7:101820155 G/A cg06246474 chr7:101738831 CUX1 0.41 6.03 0.32 4.29e-9 Plasma omega-3 polyunsaturated fatty acid level (eicosapentaenoic acid); CRC cis rs9814567 0.752 rs13098546 chr3:134333161 C/T cg06109529 chr3:134205091 CEP63;ANAPC13 0.67 9.64 0.47 1.54e-19 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC trans rs2303319 0.504 rs62188988 chr2:162531068 T/C cg14875682 chr5:52083620 ITGA1;PELO -0.72 -6.07 -0.32 3.58e-9 Cognitive function; CRC cis rs6502050 0.634 rs11077973 chr17:80095191 C/T cg22110888 chr17:80059540 CCDC57 0.4 6.44 0.33 4.17e-10 Life satisfaction; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg16728516 chr1:1342558 MRPL20 0.47 6.59 0.34 1.73e-10 Anxiety disorder; CRC cis rs6456156 0.774 rs2022001 chr6:167529509 C/T cg07513332 chr6:167530253 CCR6 -0.47 -8.65 -0.43 2.28e-16 Primary biliary cholangitis; CRC cis rs7771547 0.573 rs10440841 chr6:36399086 G/A cg04289385 chr6:36355825 ETV7 -0.38 -5.6 -0.3 4.47e-8 Platelet distribution width; CRC trans rs2018683 0.899 rs10269454 chr7:28978400 C/T cg19402173 chr7:128379420 CALU -0.56 -8.45 -0.42 9.43e-16 Response to irinotecan and platinum-based chemotherapy in non-small-cell lung cancer; CRC cis rs2836950 0.501 rs4818018 chr21:40694072 C/T cg06238570 chr21:40685208 BRWD1 -0.59 -8.56 -0.43 4.54e-16 Menarche (age at onset); CRC trans rs7618501 1.000 rs3811696 chr3:49761605 C/T cg21665057 chr3:196295764 WDR53;FBXO45 -0.86 -16.05 -0.66 3.08e-43 Intelligence (multi-trait analysis); CRC trans rs7618501 1.000 rs7634902 chr3:49762662 G/T cg21659725 chr3:3221576 CRBN -0.9 -17.34 -0.69 2.66e-48 Intelligence (multi-trait analysis); CRC cis rs208520 0.690 rs10455194 chr6:66743356 A/G cg07460842 chr6:66804631 NA 1.06 14.78 0.63 2.91e-38 Exhaled nitric oxide output; CRC cis rs7666738 0.830 rs17027225 chr4:99028564 C/T cg05340658 chr4:99064831 C4orf37 0.61 9.42 0.46 8.23e-19 Colonoscopy-negative controls vs population controls; CRC cis rs28386778 0.897 rs894406 chr17:61901657 A/G cg07362569 chr17:61921086 SMARCD2 0.38 5.95 0.31 6.87e-9 Prudent dietary pattern; CRC cis rs10883723 0.810 rs7093028 chr10:104259417 A/G cg04362960 chr10:104952993 NT5C2 -0.43 -6.1 -0.32 2.92e-9 Allergic disease (asthma, hay fever or eczema); CRC cis rs7666738 0.830 rs1967977 chr4:98966141 A/G cg17366294 chr4:99064904 C4orf37 0.43 7.36 0.38 1.49e-12 Colonoscopy-negative controls vs population controls; CRC cis rs3750082 0.889 rs1817050 chr7:32931906 T/G cg05721444 chr7:32995514 FKBP9 0.5 7.71 0.39 1.54e-13 Glomerular filtration rate (creatinine); CRC cis rs1552244 1.000 rs6764068 chr3:10153842 A/G cg18598329 chr3:10140678 FANCD2;C3orf24 -0.89 -11.73 -0.54 8.45e-27 Alzheimer's disease; CRC cis rs7809950 0.678 rs2395868 chr7:106897500 C/T cg23024343 chr7:107201750 COG5 0.69 9.56 0.47 2.94e-19 Coronary artery disease; CRC cis rs950169 0.800 rs4842847 chr15:84931199 G/A cg17507749 chr15:85114479 UBE2QP1 0.75 10.86 0.51 1.11e-23 Schizophrenia; CRC cis rs6951245 0.935 rs11766669 chr7:1063593 C/T cg20603222 chr7:1096387 C7orf50;GPR146 -0.67 -7.81 -0.4 7.54e-14 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs13336428 0.730 rs28653458 chr16:1525850 T/C cg07835181 chr16:1525278 CLCN7 0.69 11.25 0.53 4.66e-25 Bone mineral density; CRC trans rs62103177 0.525 rs4283293 chr18:77759582 A/G cg05926928 chr17:57297772 GDPD1 -0.67 -7.7 -0.39 1.61e-13 Opioid sensitivity; CRC cis rs2549003 1.000 rs2706384 chr5:131826880 G/T cg21138405 chr5:131827807 IRF1 -0.58 -11.3 -0.53 3.09e-25 Asthma (sex interaction); CRC trans rs877282 0.891 rs11253393 chr10:788824 G/T cg22713356 chr15:30763199 NA 1.35 16.39 0.67 1.43e-44 Uric acid levels; CRC trans rs1200821 0.671 rs2226276 chr10:37673052 A/T cg25427524 chr10:38739819 LOC399744 0.42 6.26 0.33 1.21e-9 Hemostatic factors and hematological phenotypes; CRC cis rs7474896 0.559 rs1208560 chr10:38221618 A/T cg25427524 chr10:38739819 LOC399744 0.59 7.32 0.37 1.92e-12 Obesity (extreme); CRC cis rs62408225 1.000 rs1604831 chr6:90967197 G/A cg06866423 chr6:90926672 BACH2 0.49 8.16 0.41 7.32e-15 Eosinophil counts;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC cis rs7632954 0.967 rs7638980 chr3:8529618 C/G cg03495237 chr3:8533978 NA 0.35 5.76 0.3 1.94e-8 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs1552244 0.752 rs9867091 chr3:10043429 T/C cg16606324 chr3:10149918 C3orf24 0.61 8.26 0.41 3.48e-15 Alzheimer's disease; CRC cis rs9311676 0.656 rs62258127 chr3:58397102 G/A cg06643156 chr3:58380774 PXK 0.42 6.38 0.33 5.84e-10 Systemic lupus erythematosus; CRC cis rs875971 0.862 rs35378740 chr7:65987712 C/A cg18252515 chr7:66147081 NA -0.43 -6.21 -0.32 1.61e-9 Aortic root size; CRC cis rs6121246 0.738 rs2376996 chr20:30316667 T/A cg18721089 chr20:30220636 NA -0.34 -5.64 -0.3 3.61e-8 Mean corpuscular hemoglobin; CRC cis rs1862618 0.802 rs7733041 chr5:56107377 A/C cg12311346 chr5:56204834 C5orf35 -0.69 -9.17 -0.45 5.35e-18 Initial pursuit acceleration; CRC trans rs2288327 0.643 rs16866334 chr2:179336672 A/G cg14011486 chr1:26737247 LIN28 0.44 6.29 0.33 1.04e-9 Atrial fibrillation; CRC cis rs61160187 0.582 rs4700402 chr5:60262047 A/G cg16298547 chr5:60138761 ELOVL7 -0.26 -5.6 -0.3 4.47e-8 Educational attainment (years of education);Educational attainment (college completion); CRC cis rs10504229 0.639 rs55687236 chr8:58105856 C/T cg11062466 chr8:58055876 NA 0.6 7.29 0.37 2.36e-12 Developmental language disorder (linguistic errors); CRC cis rs743757 1.000 rs743757 chr3:50476378 C/G cg08207895 chr3:50388901 TUSC4;CYB561D2 -0.46 -6.71 -0.35 8.58e-11 Diastolic blood pressure; CRC cis rs2456568 0.570 rs1827932 chr11:93663319 A/T cg26875233 chr11:93583750 C11orf90 -0.36 -6.9 -0.36 2.67e-11 Response to serotonin reuptake inhibitors in major depressive disorder; CRC cis rs7149337 0.805 rs7146561 chr14:51608889 C/G cg18683604 chr14:51561293 TRIM9 0.3 6.05 0.32 4.03e-9 Cancer; CRC cis rs79349575 0.687 rs12602179 chr17:47010034 G/T cg00947319 chr17:47005597 UBE2Z -0.34 -5.89 -0.31 9.32e-9 Type 2 diabetes; CRC trans rs951252 0.504 rs11734405 chr4:146081096 C/T cg21767207 chr19:36236454 PSENEN;U2AF1L4 0.45 5.96 0.31 6.33e-9 Hip circumference; CRC cis rs10540 1.000 rs117339389 chr11:505025 T/A cg03934478 chr11:495069 RNH1 0.69 7.61 0.39 2.91e-13 Body mass index; CRC cis rs8044868 0.530 rs2288002 chr16:72057282 A/G cg06172871 chr16:72088244 HP 0.39 5.69 0.3 2.81e-8 Body mass index (change over time) in cancer or chronic obstructive pulmonary disease;Body mass index (change over time) in cancer; CRC cis rs929354 0.772 rs6969244 chr7:157004012 A/G cg16102536 chr7:156981717 UBE3C 0.4 6.73 0.35 7.74e-11 Body mass index; CRC cis rs6121246 0.512 rs45443696 chr20:30311396 A/C cg13852791 chr20:30311386 BCL2L1 0.76 15.33 0.65 2.19e-40 Mean corpuscular hemoglobin; CRC trans rs7937682 0.889 rs487985 chr11:111517908 G/A cg18187862 chr3:45730750 SACM1L 0.48 6.88 0.35 3.04e-11 Primary sclerosing cholangitis; CRC cis rs66573146 0.572 rs66734745 chr4:6948765 T/C cg00086871 chr4:6988644 TBC1D14 0.88 8.49 0.42 6.96e-16 Granulocyte percentage of myeloid white cells; CRC cis rs13108904 0.870 rs1960426 chr4:1274365 C/T cg20092199 chr4:1342459 KIAA1530 0.34 5.96 0.31 6.56e-9 Obesity-related traits; CRC cis rs1555895 0.543 rs749297 chr10:861837 A/G cg10556349 chr10:835070 NA -0.36 -7.08 -0.36 8.85e-12 Survival in rectal cancer; CRC cis rs17345786 0.906 rs72946021 chr3:101250008 T/G cg11279151 chr3:101281821 RG9MTD1 -0.67 -8.3 -0.42 2.7e-15 Colonoscopy-negative controls vs population controls; CRC trans rs7395662 0.781 rs11499902 chr11:48742731 G/A cg21153622 chr11:89784906 NA -0.48 -7.81 -0.4 7.58e-14 HDL cholesterol; CRC cis rs9434723 0.841 rs9435152 chr1:9308249 C/T cg04199779 chr1:9294473 H6PD 0.55 6.17 0.32 2.04e-9 Height; CRC cis rs2050392 0.590 rs2065723 chr10:30720462 A/T cg25182066 chr10:30743637 MAP3K8 -0.46 -6.09 -0.32 3.14e-9 Inflammatory bowel disease; CRC cis rs992157 0.764 rs4672886 chr2:219185545 C/T cg04880052 chr2:219191631 PNKD -0.44 -6.59 -0.34 1.79e-10 Colorectal cancer; CRC cis rs9814567 0.806 rs9857242 chr3:134316378 A/G cg06109529 chr3:134205091 CEP63;ANAPC13 0.68 10.04 0.48 7.19e-21 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs7524258 0.900 rs1476047 chr1:7312172 C/T cg07173049 chr1:7289937 CAMTA1 0.49 8.05 0.41 1.51e-14 Tourette's syndrome or obsessive-compulsive disorder; CRC cis rs62229266 0.625 rs2051395 chr21:37431265 A/C cg08632701 chr21:37451849 NA 0.41 6.5 0.34 3.04e-10 Mitral valve prolapse; CRC cis rs6951245 1.000 rs6951245 chr7:1058193 G/A cg04025307 chr7:1156635 C7orf50 0.66 7.01 0.36 1.34e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs10504229 1.000 rs116444534 chr8:58181915 A/G cg02290350 chr8:58132656 NA -0.44 -6.41 -0.33 5.13e-10 Developmental language disorder (linguistic errors); CRC cis rs73058052 0.597 rs2288921 chr19:50092002 G/T cg15963326 chr19:50037085 RCN3 0.36 5.76 0.3 1.98e-8 Fibrinogen levels; CRC cis rs2832191 0.692 rs8134627 chr21:30349069 C/T cg08807101 chr21:30365312 RNF160 -0.73 -11.73 -0.54 8.7e-27 Dental caries; CRC cis rs8180040 0.800 rs11130126 chr3:47306894 A/G cg27129171 chr3:47204927 SETD2 -0.66 -9.98 -0.48 1.13e-20 Colorectal cancer; CRC cis rs12620999 0.774 rs6711726 chr2:238101795 C/T cg23555395 chr2:238036564 NA -0.51 -7.97 -0.4 2.66e-14 Systemic lupus erythematosus; CRC cis rs7584330 0.740 rs11891348 chr2:238440449 T/G cg14458575 chr2:238380390 NA 0.68 11.45 0.53 8.78e-26 Prostate cancer; CRC cis rs875971 0.545 rs75840613 chr7:65841386 G/A cg05627663 chr7:65219948 SNORA22;CCT6P1 0.62 7.91 0.4 3.82e-14 Aortic root size; CRC cis rs910316 0.737 rs175043 chr14:75471803 G/A cg08847533 chr14:75593920 NEK9 -0.86 -14.5 -0.62 3.42e-37 Height; CRC cis rs4563143 0.647 rs117442062 chr19:29256823 A/T cg12667521 chr19:29218732 NA 0.49 7.49 0.38 6.39e-13 Methadone dose in opioid dependence; CRC cis rs9858542 0.953 rs7648841 chr3:49416825 G/A cg03060546 chr3:49711283 APEH -0.48 -6.81 -0.35 4.64e-11 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs3892630 0.588 rs8106748 chr19:33282797 G/A cg22980127 chr19:33182716 NUDT19 0.91 12.52 0.57 1.16e-29 Red blood cell traits; CRC cis rs67340775 0.541 rs200974 chr6:27855845 A/G cg19041857 chr6:27730383 NA -0.62 -6.8 -0.35 5.04e-11 Lung cancer in ever smokers; CRC cis rs2949837 0.581 rs1542819 chr7:45978059 T/C cg06713098 chr7:45960367 IGFBP3 0.42 6.71 0.35 8.43e-11 Sitting height ratio; CRC cis rs72802342 0.541 rs185052 chr16:75467063 C/T cg03315344 chr16:75512273 CHST6 -0.51 -5.94 -0.31 7.05e-9 Advanced age-related macular degeneration; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg07650554 chr16:30457408 SEPHS2 0.43 6.08 0.32 3.31e-9 Response to antipsychotic treatment; CRC cis rs34172651 0.517 rs7204288 chr16:24784531 A/G cg04756594 chr16:24857601 SLC5A11 0.33 6.77 0.35 5.99e-11 Intelligence (multi-trait analysis); CRC cis rs3733585 0.699 rs4276278 chr4:9948870 T/C cg11266682 chr4:10021025 SLC2A9 -0.46 -9.15 -0.45 6.28e-18 Cleft plate (environmental tobacco smoke interaction); CRC cis rs1552244 0.935 rs6805869 chr3:10119917 T/C cg18598329 chr3:10140678 FANCD2;C3orf24 -0.9 -12.84 -0.58 7.52e-31 Alzheimer's disease; CRC cis rs1552244 0.882 rs2130813 chr3:10038706 A/C cg10729496 chr3:10149963 C3orf24 0.5 6.53 0.34 2.55e-10 Alzheimer's disease; CRC cis rs477895 0.653 rs2015226 chr11:63902534 C/T cg19465662 chr11:63993652 NUDT22;TRPT1 0.73 8.97 0.44 2.22e-17 Mean platelet volume; CRC cis rs2841277 0.708 rs10083374 chr14:105402994 T/C cg15352829 chr14:105391018 PLD4 -0.49 -10.82 -0.51 1.55e-23 Rheumatoid arthritis; CRC cis rs951366 0.617 rs823074 chr1:205774839 T/C cg07157834 chr1:205819609 PM20D1 0.97 16.82 0.68 2.99e-46 Menarche (age at onset); CRC cis rs514406 0.861 rs1571979 chr1:53237526 G/A cg27535305 chr1:53392650 SCP2 0.39 7.07 0.36 9.17e-12 Monocyte count; CRC cis rs7223966 1.000 rs2854219 chr17:61942682 C/T cg05941027 chr17:61774174 LIMD2 0.33 5.63 0.3 3.8e-8 Hip circumference adjusted for BMI;Body mass index; CRC cis rs514406 0.823 rs501006 chr1:53368292 T/A cg08859206 chr1:53392774 SCP2 -0.51 -8.0 -0.4 2.2e-14 Monocyte count; CRC cis rs921968 0.541 rs588770 chr2:219494638 T/C cg02176678 chr2:219576539 TTLL4 0.55 8.7 0.43 1.59e-16 Mean corpuscular hemoglobin concentration; CRC cis rs6570726 0.935 rs12663211 chr6:145818427 G/A cg05347473 chr6:146136440 FBXO30 0.37 6.0 0.31 5.27e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs798554 0.836 rs798500 chr7:2790685 C/T cg19717773 chr7:2847554 GNA12 0.46 6.65 0.34 1.19e-10 Height; CRC cis rs6547741 0.844 rs9678851 chr2:27887034 C/A cg27432699 chr2:27873401 GPN1 -0.86 -16.82 -0.68 2.95e-46 Oral cavity cancer; CRC cis rs7044106 0.537 rs10739573 chr9:123489818 A/G cg09586646 chr9:123605570 PSMD5;LOC253039 0.7 8.95 0.44 2.6e-17 Hip circumference adjusted for BMI; CRC cis rs11971779 0.648 rs4732367 chr7:139028102 A/C cg23387468 chr7:139079360 LUC7L2 0.41 7.29 0.37 2.34e-12 Diisocyanate-induced asthma; CRC cis rs4466137 0.953 rs974023 chr5:83014848 T/C cg16102102 chr5:83017553 HAPLN1 -0.54 -7.78 -0.39 9.48e-14 Prostate cancer; CRC cis rs17209837 1.000 rs2302387 chr7:87092185 G/A cg00919237 chr7:87102261 ABCB4 -0.49 -6.03 -0.32 4.4e-9 Gallbladder cancer; CRC cis rs6692729 0.901 rs4653470 chr1:227082726 T/A cg18027831 chr1:227083489 PSEN2 0.36 5.92 0.31 7.88e-9 Electrodermal activity; CRC cis rs559928 0.606 rs76653616 chr11:63936139 T/G cg19465662 chr11:63993652 NUDT22;TRPT1 0.7 6.67 0.34 1.11e-10 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; CRC trans rs61931739 0.500 rs11053278 chr12:34555955 T/C cg13010199 chr12:38710504 ALG10B 0.46 6.57 0.34 2.02e-10 Morning vs. evening chronotype; CRC cis rs7772486 0.875 rs10457795 chr6:146415665 A/G cg23711669 chr6:146136114 FBXO30 0.67 11.54 0.54 4.2e-26 Lobe attachment (rater-scored or self-reported); CRC cis rs10883723 0.810 rs10786671 chr10:104271303 G/A cg04362960 chr10:104952993 NT5C2 -0.45 -6.32 -0.33 8.39e-10 Allergic disease (asthma, hay fever or eczema); CRC cis rs7647973 0.626 rs4855845 chr3:49687043 T/C cg03060546 chr3:49711283 APEH 0.67 8.26 0.41 3.57e-15 Menarche (age at onset); CRC cis rs559928 0.606 rs60394481 chr11:63909035 G/A cg19465662 chr11:63993652 NUDT22;TRPT1 0.7 6.72 0.35 7.98e-11 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; CRC cis rs6502050 0.830 rs7219036 chr17:80161119 T/C cg09264619 chr17:80180166 NA -0.36 -6.08 -0.32 3.42e-9 Life satisfaction; CRC cis rs17376456 0.877 rs35075119 chr5:93385457 T/C cg09848695 chr5:92956644 FAM172A;MIR2277 0.64 6.26 0.33 1.22e-9 Diabetic retinopathy; CRC cis rs1552244 1.000 rs17032283 chr3:10081545 C/G cg10729496 chr3:10149963 C3orf24 0.51 6.68 0.35 1.04e-10 Alzheimer's disease; CRC cis rs75920871 0.528 rs2513097 chr11:116836212 A/G cg20608306 chr11:116969690 SIK3 -0.33 -6.39 -0.33 5.73e-10 Subjective well-being; CRC trans rs2303319 0.504 rs62189048 chr2:162613494 G/C cg22677401 chr17:46026860 NA -0.67 -6.07 -0.32 3.57e-9 Cognitive function; CRC cis rs4665809 1.000 rs4665820 chr2:26309150 T/C cg25036284 chr2:26402008 FAM59B -0.46 -6.03 -0.32 4.3e-9 Gut microbiome composition (summer); CRC cis rs67311347 0.911 rs6775936 chr3:40377399 T/G cg24209194 chr3:40518798 ZNF619 0.41 6.01 0.31 4.82e-9 Renal cell carcinoma; CRC cis rs2239547 0.522 rs6768844 chr3:53004620 A/G cg05573699 chr3:52720067 GNL3;PBRM1 0.42 5.74 0.3 2.11e-8 Schizophrenia; CRC cis rs13082711 0.871 rs35572617 chr3:27499247 A/T cg02860705 chr3:27208620 NA 0.63 8.91 0.44 3.46e-17 Systolic blood pressure;Diastolic blood pressure;Blood pressure; CRC cis rs11212617 1.000 rs641605 chr11:108101919 C/T cg14761454 chr11:108092087 ATM;NPAT 0.43 6.3 0.33 9.5e-10 Response to metformin in type 2 diabetes (glycemic); CRC trans rs1346081 0.786 rs1425645 chr4:68028175 C/T cg24489972 chr7:105817320 NA 0.5 6.36 0.33 6.93e-10 Intelligence (multi-trait analysis); CRC cis rs1401999 0.898 rs4148561 chr3:183726379 A/G cg05044414 chr3:183734942 ABCC5 0.45 7.66 0.39 2.13e-13 Anterior chamber depth; CRC cis rs3741151 0.686 rs17132115 chr11:73264656 C/T cg17517138 chr11:73019481 ARHGEF17 0.55 5.62 0.3 4.03e-8 GIP levels in response to oral glucose tolerance test (120 minutes); CRC cis rs12540874 0.759 rs12718572 chr7:50573325 C/T cg14593290 chr7:50529359 DDC -0.44 -6.12 -0.32 2.72e-9 Systemic sclerosis; CRC cis rs4689388 0.853 rs4293850 chr4:6292020 A/C cg00701064 chr4:6280414 WFS1 0.73 12.82 0.58 8.29e-31 Type 2 diabetes and other traits;Type 2 diabetes; CRC cis rs394563 0.601 rs391875 chr6:149795136 G/A cg11245181 chr6:149772854 ZC3H12D -0.45 -7.16 -0.37 5.33e-12 Dupuytren's disease; CRC cis rs887829 0.569 rs3821242 chr2:234637803 T/C cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.54 -8.76 -0.44 1.02e-16 Metabolic traits;Bilirubin levels;Cholelithiasis-related traits in sickle cell anemia;Metabolite levels;Total bilirubin levels in HIV-1 infection;Serum metabolite levels;Blood metabolite levels; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg15216925 chr5:179921655 CNOT6 -0.4 -6.17 -0.32 1.99e-9 Myopia (pathological); CRC cis rs9462027 0.628 rs9469886 chr6:34758824 C/T cg07306190 chr6:34760872 UHRF1BP1 -0.35 -6.23 -0.32 1.43e-9 Systemic lupus erythematosus; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg10318443 chr17:685449 GLOD4;RNMTL1 0.43 6.46 0.34 3.66e-10 Intelligence (multi-trait analysis); CRC cis rs10504229 0.906 rs903718 chr8:58167726 A/G cg02725872 chr8:58115012 NA -0.45 -8.62 -0.43 2.91e-16 Developmental language disorder (linguistic errors); CRC cis rs4481887 1.000 rs4481887 chr1:248496863 A/G cg00666640 chr1:248458726 OR2T12 0.55 9.38 0.46 1.1e-18 Common traits (Other); CRC cis rs4474465 1.000 rs10793313 chr11:78169310 C/T cg27205649 chr11:78285834 NARS2 -0.48 -5.85 -0.31 1.18e-8 Alzheimer's disease (survival time); CRC cis rs10504229 0.639 rs55687236 chr8:58105856 C/T cg08219700 chr8:58056026 NA 0.6 6.93 0.36 2.16e-11 Developmental language disorder (linguistic errors); CRC cis rs1008375 1.000 rs55939327 chr4:17642937 T/A cg16339924 chr4:17578868 LAP3 0.58 7.81 0.4 7.95e-14 Parasitemia in Tripanosoma cruzi seropositivity; CRC trans rs17177486 0.661 rs2050931 chr1:203304679 C/T cg09587487 chr1:178993784 FAM20B -0.89 -6.1 -0.32 2.9e-9 Mumps; CRC trans rs7705042 0.659 rs11743029 chr5:141509282 G/A cg03701575 chr16:83960119 NA -0.37 -5.98 -0.31 5.76e-9 Asthma; CRC cis rs3087591 1.000 rs2905870 chr17:29521833 G/A cg24425628 chr17:29625626 OMG;NF1 0.85 16.19 0.67 9.08e-44 Hip circumference; CRC cis rs12134245 1.000 rs12134245 chr1:92021464 C/T cg25838465 chr1:92012736 NA -0.65 -10.98 -0.52 4.29e-24 Breast cancer; CRC trans rs800082 1.000 rs1405596 chr3:144314033 C/G cg24215973 chr2:240111563 HDAC4 -0.53 -7.52 -0.38 5.16e-13 Smoking behavior; CRC cis rs7762018 0.655 rs2184195 chr6:170148397 C/T cg17545662 chr6:170176663 C6orf70 0.57 6.45 0.34 3.99e-10 Thiazide-induced adverse metabolic effects in hypertensive patients; CRC cis rs597539 0.652 rs544370 chr11:68653232 C/T cg06112835 chr11:68658793 MRPL21 0.46 7.67 0.39 1.97e-13 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs9399135 0.967 rs952674 chr6:135349157 A/G cg24558204 chr6:135376177 HBS1L 0.52 8.21 0.41 5.05e-15 Red blood cell count; CRC cis rs62229266 0.804 rs62230822 chr21:37429945 T/C cg12218747 chr21:37451666 NA -0.46 -7.89 -0.4 4.48e-14 Mitral valve prolapse; CRC cis rs1519814 0.740 rs2326433 chr8:121043723 T/A cg22335954 chr8:121166405 COL14A1 -0.51 -5.78 -0.3 1.72e-8 Breast cancer; CRC cis rs854572 0.600 rs705382 chr7:94955221 C/G cg21856205 chr7:94953877 PON1 -0.67 -11.9 -0.55 2.21e-27 Paraoxonase activity; CRC cis rs3087591 0.920 rs7225014 chr17:29572973 A/G cg24425628 chr17:29625626 OMG;NF1 -0.87 -16.9 -0.68 1.51e-46 Hip circumference; CRC cis rs6835098 0.924 rs1991727 chr4:174163169 A/G cg08422745 chr4:174089978 GALNT7 -0.85 -13.67 -0.6 5.47e-34 Dementia and core Alzheimer's disease neuropathologic changes; CRC cis rs644799 0.526 rs693792 chr11:95622200 C/T cg25622487 chr11:95524042 FAM76B;CEP57 0.51 7.56 0.38 4.1e-13 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs863345 0.604 rs1578761 chr1:158497572 G/A cg12129480 chr1:158549410 OR10X1 -0.29 -5.95 -0.31 6.94e-9 Pneumococcal bacteremia; CRC cis rs4908760 0.965 rs7542312 chr1:8573471 G/C cg20416874 chr1:8611966 RERE -0.44 -6.26 -0.33 1.19e-9 Vitiligo; CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg06028048 chr5:175815674 HIGD2A;NOP16 -0.51 -6.21 -0.32 1.63e-9 Diisocyanate-induced asthma; CRC cis rs3806843 1.000 rs6579987 chr5:140183659 T/C cg16607685 chr5:140181889 PCDHA2;PCDHA1;PCDHA3 -0.27 -6.15 -0.32 2.3e-9 Depressive symptoms (multi-trait analysis); CRC trans rs13046373 0.905 rs4816372 chr21:32077414 A/T cg21557407 chr3:178865550 PIK3CA -0.4 -6.05 -0.32 4.01e-9 HDL cholesterol; CRC cis rs4713118 0.824 rs7759217 chr6:27730463 A/G cg26587870 chr6:27730563 NA -0.46 -6.82 -0.35 4.26e-11 Parkinson's disease; CRC cis rs9902453 0.780 rs7210991 chr17:28190961 T/C cg26525008 chr17:28256777 EFCAB5;SSH2 0.57 8.69 0.43 1.78e-16 Coffee consumption (cups per day); CRC cis rs7772486 0.875 rs2777481 chr6:146310036 G/T cg23711669 chr6:146136114 FBXO30 0.63 10.57 0.5 1.12e-22 Lobe attachment (rater-scored or self-reported); CRC cis rs3540 0.512 rs3862434 chr15:91080387 C/T cg22089800 chr15:90895588 ZNF774 0.57 9.61 0.47 1.97e-19 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; CRC cis rs2072510 0.593 rs2660892 chr12:96420978 T/C cg22491680 chr12:96389547 HAL -0.47 -5.75 -0.3 2e-8 Metabolite levels (small molecules and protein measures); CRC cis rs2011503 1.000 rs55927782 chr19:19642032 T/C cg11584989 chr19:19387371 SF4 0.59 6.44 0.33 4.34e-10 Bipolar disorder; CRC cis rs9462027 0.606 rs6906129 chr6:34801160 A/G cg07306190 chr6:34760872 UHRF1BP1 -0.35 -6.15 -0.32 2.24e-9 Systemic lupus erythematosus; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg19320564 chr1:40157253 HPCAL4 0.37 6.23 0.32 1.41e-9 Liver disease severity in Alagille syndrome; CRC cis rs1153858 0.887 rs28569043 chr15:45730926 A/T cg14582100 chr15:45693742 SPATA5L1 0.3 6.23 0.32 1.47e-9 Homoarginine levels; CRC cis rs425277 0.958 rs262688 chr1:2113565 T/G cg24578937 chr1:2090814 PRKCZ 0.67 11.71 0.54 1.03e-26 Height; CRC cis rs7224685 0.501 rs1878332 chr17:3904446 G/A cg05562828 chr17:3906858 NA 0.73 14.0 0.61 2.86e-35 Type 2 diabetes; CRC cis rs7089973 0.604 rs2420065 chr10:116583753 A/G cg23260525 chr10:116636907 FAM160B1 0.35 8.07 0.41 1.34e-14 Bipolar disorder or attention deficit hyperactivity disorder; CRC trans rs208520 0.802 rs208496 chr6:66930786 G/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.93 -12.03 -0.55 7.12e-28 Exhaled nitric oxide output; CRC cis rs7587476 0.861 rs17488049 chr2:215651750 G/A cg04004882 chr2:215674386 BARD1 0.63 7.08 0.36 8.86e-12 Neuroblastoma; CRC cis rs7809950 0.648 rs114452520 chr7:107176780 C/T cg23024343 chr7:107201750 COG5 -0.63 -8.83 -0.44 6.51e-17 Coronary artery disease; CRC cis rs1552244 0.554 rs2272121 chr3:10047680 A/G cg18598329 chr3:10140678 FANCD2;C3orf24 -0.54 -7.63 -0.39 2.52e-13 Alzheimer's disease; CRC cis rs9826463 0.757 rs73240305 chr3:142222770 A/G cg20824294 chr3:142316082 PLS1 0.41 6.89 0.36 2.77e-11 QRS duration in Tripanosoma cruzi seropositivity; CRC cis rs6502050 0.787 rs7222326 chr17:80057272 T/C cg02741985 chr17:80059408 CCDC57 -0.45 -7.29 -0.37 2.35e-12 Life satisfaction; CRC cis rs1887596 0.705 rs1590954 chr13:27200239 A/G cg01312412 chr13:27282625 NA 0.45 5.75 0.3 2.01e-8 Facial morphology (factor 3, length of philtrum); CRC trans rs7615952 0.932 rs13086087 chr3:125646281 A/C cg07211511 chr3:129823064 LOC729375 -1.06 -17.68 -0.7 1.19e-49 Blood pressure (smoking interaction); CRC cis rs9549328 0.765 rs1317506 chr13:113631143 C/T cg25790453 chr13:113633590 MCF2L -0.44 -7.82 -0.4 7.3e-14 Systolic blood pressure; CRC trans rs10155879 0.505 rs12704265 chr7:86142678 A/G cg08322149 chr10:46222875 FAM21C 0.57 6.11 0.32 2.76e-9 Interleukin-4 levels; CRC cis rs2979489 0.773 rs2915617 chr8:30272310 C/G cg26383811 chr8:30366931 RBPMS 0.48 6.87 0.35 3.27e-11 Mean corpuscular hemoglobin;Plateletcrit;Neutrophil count;Granulocyte count;Sum basophil neutrophil counts;Mean corpuscular volume;Myeloid white cell count;Sum neutrophil eosinophil counts; CRC cis rs1552244 1.000 rs9881859 chr3:10072814 A/T cg02579736 chr3:10068473 FANCD2;CIDECP 0.95 12.44 0.57 2.13e-29 Alzheimer's disease; CRC cis rs2717559 0.522 rs10956987 chr8:143886613 T/C cg15511327 chr8:143859410 LYNX1 -0.62 -11.11 -0.52 1.46e-24 Urinary tract infection frequency; CRC cis rs10848704 0.525 rs4765709 chr12:2883637 C/T cg19995117 chr12:2880862 NA 0.37 6.55 0.34 2.19e-10 Quantitative traits; CRC cis rs9905704 0.874 rs28483505 chr17:56844109 G/C cg12560992 chr17:57184187 TRIM37 0.53 7.22 0.37 3.69e-12 Testicular germ cell tumor; CRC cis rs7617773 0.743 rs11716371 chr3:48362750 C/T cg11946769 chr3:48343235 NME6 0.72 9.58 0.47 2.48e-19 Coronary artery disease; CRC cis rs524281 0.773 rs2155030 chr11:66030687 A/G cg14036092 chr11:66035641 RAB1B -0.55 -6.04 -0.32 4.16e-9 Electroencephalogram traits; CRC cis rs7113874 0.589 rs10840060 chr11:8500045 A/C cg20771178 chr11:8615675 STK33 0.36 5.85 0.31 1.21e-8 Body mass index in physically active individuals;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs9992667 0.955 rs6855993 chr4:38608912 A/T cg19726192 chr4:38663646 FLJ13197 -0.54 -7.14 -0.37 5.98e-12 Eosinophil percentage of granulocytes; CRC cis rs9911578 1.000 rs7216680 chr17:56988243 G/C cg05425664 chr17:57184151 TRIM37 -0.5 -7.81 -0.4 7.69e-14 Intelligence (multi-trait analysis); CRC cis rs2842992 0.709 rs1853257 chr6:160212710 C/G cg16489826 chr6:160211363 TCP1;MRPL18 0.49 6.28 0.33 1.07e-9 Age-related macular degeneration (geographic atrophy); CRC cis rs4689592 0.554 rs3822270 chr4:7069804 C/A cg26116260 chr4:7069785 GRPEL1 0.99 14.98 0.64 4.76e-39 Monocyte percentage of white cells; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg01133099 chr17:1933418 DPH1 0.43 6.21 0.32 1.61e-9 Intelligence (multi-trait analysis); CRC cis rs11785693 0.862 rs17350978 chr8:4983418 G/C cg26367366 chr8:4980734 NA 0.8 9.67 0.47 1.21e-19 Neuroticism (multi-trait analysis);Neuroticism; CRC cis rs7119 0.717 rs12899390 chr15:77815238 A/C cg10437265 chr15:77819839 NA 0.7 12.76 0.58 1.44e-30 Type 2 diabetes; CRC cis rs6502050 0.761 rs11653003 chr17:80058795 G/T cg13198984 chr17:80129470 CCDC57 -0.43 -7.3 -0.37 2.19e-12 Life satisfaction; CRC trans rs1499614 1.000 rs1267818 chr7:66107024 C/T cg10756647 chr7:56101905 PSPH 0.75 7.74 0.39 1.26e-13 Gout; CRC cis rs9486719 1.000 rs2971603 chr6:97035418 C/T cg06623918 chr6:96969491 KIAA0776 -0.82 -11.38 -0.53 1.57e-25 Migraine;Coronary artery disease; CRC cis rs12594515 1.000 rs7172161 chr15:45990780 A/G cg06207120 chr15:45996521 NA 0.32 7.75 0.39 1.14e-13 Waist circumference;Weight; CRC cis rs4908768 0.501 rs4351668 chr1:8535818 C/T cg20416874 chr1:8611966 RERE -0.45 -6.42 -0.33 4.68e-10 Neuroticism (multi-trait analysis);Subjective well-being (multi-trait analysis); CRC cis rs1153858 1.000 rs4775911 chr15:45649787 G/T cg21132104 chr15:45694354 SPATA5L1 -0.59 -8.61 -0.43 3e-16 Homoarginine levels; CRC cis rs910187 0.605 rs6066223 chr20:45803998 A/G cg27589058 chr20:45804311 EYA2 0.44 8.99 0.44 1.92e-17 Migraine; CRC cis rs6908034 0.607 rs79162793 chr6:19813065 A/G cg02682789 chr6:19804855 NA 0.81 6.48 0.34 3.35e-10 Endometriosis;Deep ovarian and/or rectovaginal disease with dense adhesions; CRC cis rs6835098 1.000 rs1054496 chr4:174089080 A/G cg08422745 chr4:174089978 GALNT7 -0.96 -15.36 -0.65 1.56e-40 Dementia and core Alzheimer's disease neuropathologic changes; CRC cis rs13217239 0.646 rs35691005 chr6:26972070 A/G cg05192639 chr6:26864778 GUSBL1 0.31 6.01 0.31 5.05e-9 Schizophrenia; CRC trans rs7615952 0.512 rs2922175 chr3:125361360 T/C cg07211511 chr3:129823064 LOC729375 -0.63 -8.76 -0.43 1.03e-16 Blood pressure (smoking interaction); CRC cis rs6665290 0.935 rs1929864 chr1:227195500 T/G cg10327440 chr1:227177885 CDC42BPA -1.04 -22.89 -0.78 4.88e-70 Myeloid white cell count; CRC cis rs910316 0.763 rs175042 chr14:75470833 A/T cg11812906 chr14:75593930 NEK9 -0.58 -8.87 -0.44 4.75e-17 Height; CRC cis rs1448094 0.511 rs7139088 chr12:86147878 T/C cg18827107 chr12:86230957 RASSF9 0.39 5.96 0.31 6.52e-9 Major depressive disorder; CRC cis rs1003719 0.582 rs2835634 chr21:38528270 T/A cg10648535 chr21:38446584 PIGP;TTC3 -0.48 -6.67 -0.35 1.08e-10 Eye color traits; CRC cis rs12142240 0.628 rs56126529 chr1:46808860 C/T cg00530320 chr1:46809349 NSUN4 0.58 7.98 0.4 2.46e-14 Menopause (age at onset); CRC cis rs12497850 0.931 rs9311433 chr3:48863835 T/C cg07636037 chr3:49044803 WDR6 1.04 18.72 0.72 9.87e-54 Parkinson's disease; CRC cis rs11214589 0.807 rs2155463 chr11:113242301 T/C cg14159747 chr11:113255604 NA 0.52 10.02 0.48 8.44e-21 Neuroticism; CRC cis rs593982 0.920 rs72922791 chr11:65567395 G/A cg08755490 chr11:65554678 OVOL1 -0.95 -10.52 -0.5 1.71e-22 Atopic dermatitis; CRC cis rs72945132 0.882 rs72947078 chr11:70197542 G/T cg14191688 chr11:70257035 CTTN 0.48 6.17 0.32 2.02e-9 Coronary artery disease; CRC cis rs2120019 1.000 rs8036197 chr15:75370232 T/C cg17294928 chr15:75287854 SCAMP5 -0.73 -10.92 -0.52 6.61e-24 Blood trace element (Zn levels); CRC trans rs6076960 0.652 rs3852945 chr20:6254118 T/C cg24759859 chr6:86352639 SYNCRIP 0.44 6.04 0.32 4.21e-9 Smooth-surface caries; CRC cis rs72634258 0.554 rs4908705 chr1:7926401 C/T cg26816564 chr1:7831052 VAMP3 0.65 8.09 0.41 1.13e-14 Inflammatory bowel disease; CRC cis rs6952808 0.630 rs4719443 chr7:2161099 A/G cg02951883 chr7:2050386 MAD1L1 -0.72 -11.21 -0.53 6.58e-25 Bipolar disorder and schizophrenia; CRC cis rs12586317 0.620 rs17103042 chr14:35575428 T/C cg16230307 chr14:35515116 FAM177A1 0.78 9.38 0.46 1.08e-18 Psoriasis; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg21271961 chr1:95285780 SLC44A3 0.45 6.63 0.34 1.35e-10 Response to antipsychotic treatment; CRC cis rs514406 0.525 rs269291 chr1:53189297 C/T cg25767906 chr1:53392781 SCP2 -0.4 -6.18 -0.32 1.9e-9 Monocyte count; CRC trans rs208520 1.000 rs72882102 chr6:66983408 C/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.88 10.79 0.51 1.94e-23 Exhaled nitric oxide output; CRC cis rs9311474 0.508 rs11714565 chr3:52606292 C/T cg18099408 chr3:52552593 STAB1 -0.48 -8.28 -0.42 3.07e-15 Electroencephalogram traits; CRC cis rs709400 0.930 rs28513222 chr14:104028069 A/T cg01849466 chr14:104193079 ZFYVE21 0.42 6.5 0.34 3.01e-10 Body mass index; CRC cis rs6502050 0.835 rs11077971 chr17:80090629 A/G cg09264619 chr17:80180166 NA -0.38 -6.46 -0.34 3.76e-10 Life satisfaction; CRC cis rs12497850 0.931 rs9840684 chr3:48893780 T/C cg20833759 chr3:49053208 WDR6;DALRD3 0.53 9.14 0.45 6.55e-18 Parkinson's disease; CRC cis rs6964587 1.000 rs10236397 chr7:91691601 C/T cg17063962 chr7:91808500 NA 0.8 14.02 0.61 2.36e-35 Breast cancer; CRC trans rs9914544 0.545 rs2892016 chr17:18786776 C/T cg21372672 chr17:16614065 CCDC144A -0.39 -6.11 -0.32 2.84e-9 Educational attainment (years of education); CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg16303686 chr3:132136102 DNAJC13 0.47 6.64 0.34 1.3e-10 Anxiety disorder; CRC cis rs9948 0.655 rs17119591 chr2:97435557 G/A cg20312557 chr2:97357134 FER1L5 -0.61 -5.64 -0.3 3.63e-8 Erectile dysfunction and prostate cancer treatment; CRC cis rs17685 0.712 rs6953342 chr7:75776753 T/C cg16489192 chr7:75678113 MDH2;STYXL1 -0.36 -5.71 -0.3 2.56e-8 Coffee consumption;Coffee consumption (cups per day); CRC cis rs10504229 1.000 rs56350499 chr8:58178139 C/T cg22535103 chr8:58192502 C8orf71 -0.82 -12.27 -0.56 9.63e-29 Developmental language disorder (linguistic errors); CRC cis rs11945232 1.000 rs28609242 chr4:88342497 T/C cg23841344 chr4:88312519 HSD17B11 -0.53 -6.8 -0.35 4.85e-11 Intelligence (multi-trait analysis); CRC cis rs875971 0.862 rs11763189 chr7:65983529 G/A cg18876405 chr7:65276391 NA 0.5 8.31 0.42 2.59e-15 Aortic root size; CRC cis rs9372498 0.505 rs4416700 chr6:118975461 G/C cg24463073 chr6:118973353 C6orf204 0.49 6.14 0.32 2.34e-9 Diastolic blood pressure; CRC cis rs7945705 0.840 rs10840136 chr11:8885024 C/T cg14711859 chr11:8959438 ASCL3 0.39 6.67 0.34 1.11e-10 Hemoglobin concentration; CRC cis rs7703744 0.597 rs73237297 chr5:118691121 G/T cg23985447 chr5:118691066 TNFAIP8 0.41 5.97 0.31 6.04e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs728616 0.867 rs28365998 chr10:81965436 C/A cg05935833 chr10:81318306 SFTPA2 -0.76 -7.53 -0.38 5.02e-13 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs58688157 0.705 rs7928902 chr11:609068 G/A cg01842473 chr11:617407 IRF7;MUPCDH -0.54 -6.48 -0.34 3.39e-10 Systemic lupus erythematosus; CRC cis rs7811142 1.000 rs7787620 chr7:100089234 A/G cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.08 15.21 0.64 6.34e-40 Platelet count; CRC cis rs7666738 0.791 rs6851549 chr4:99029827 G/A cg05340658 chr4:99064831 C4orf37 0.61 9.44 0.46 6.92e-19 Colonoscopy-negative controls vs population controls; CRC cis rs7224685 0.501 rs781852 chr17:3953102 A/G cg11204139 chr17:3907470 NA 0.77 14.69 0.63 6.34e-38 Type 2 diabetes; CRC cis rs10504229 0.775 rs55764517 chr8:58158238 G/A cg08219700 chr8:58056026 NA 0.46 5.72 0.3 2.37e-8 Developmental language disorder (linguistic errors); CRC cis rs561341 0.714 rs474455 chr17:30312465 A/T cg19193384 chr17:30244184 NA -0.52 -6.69 -0.35 9.9e-11 Hip circumference adjusted for BMI; CRC trans rs75246769 0.570 rs80127121 chr7:145690896 G/A cg14916917 chr5:81574294 RPS23 0.88 6.04 0.32 4.05e-9 Facial morphology (factor 10, width of nasal floor); CRC cis rs7249142 0.597 rs7250650 chr19:19285989 A/T cg26504305 chr19:19281019 LOC729991-MEF2B;MEF2B -0.43 -8.69 -0.43 1.68e-16 IgG glycosylation; CRC cis rs6762477 0.748 rs34877766 chr3:50234126 A/G cg24110177 chr3:50126178 RBM5 -0.44 -6.61 -0.34 1.54e-10 Menarche (age at onset); CRC cis rs7945705 0.967 rs7123861 chr11:8892323 G/A cg12365402 chr11:9010492 NRIP3 0.47 7.62 0.39 2.67e-13 Hemoglobin concentration; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg06335251 chr10:31320888 ZNF438 0.46 6.25 0.33 1.28e-9 Anxiety disorder; CRC cis rs146817970 1 rs146817970 chr5:81512947 TA/T cg17942617 chr5:81327376 ATG10 0.39 5.82 0.31 1.39e-8 Breast cancer; CRC cis rs9633740 0.504 rs1993484 chr10:82222698 T/C cg00277334 chr10:82204260 NA -0.55 -6.37 -0.33 6.38e-10 Post bronchodilator FEV1; CRC cis rs2769264 0.602 rs11204777 chr1:151072049 G/A cg04469105 chr1:151031679 CDC42SE1;MLLT11 -0.63 -7.78 -0.39 9.52e-14 Blood trace element (Cu levels); CRC cis rs2882667 0.518 rs10041986 chr5:138424437 A/G cg09476006 chr5:138032270 NA 0.36 6.03 0.32 4.37e-9 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs1534166 0.601 rs13324779 chr3:133510413 G/A cg27366882 chr3:133540807 NA -0.58 -8.65 -0.43 2.33e-16 Alcohol consumption (transferrin glycosylation); CRC cis rs4629710 0.592 rs11759926 chr6:131571269 G/T cg12606694 chr6:131520996 AKAP7 0.56 8.27 0.41 3.29e-15 Multiple myeloma (IgH translocation); CRC cis rs7568458 0.709 rs11895399 chr2:85753806 C/A cg02493740 chr2:85810744 VAMP5 -0.5 -7.57 -0.39 3.84e-13 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); CRC cis rs801193 1.000 rs3778909 chr7:66255646 G/C cg00343986 chr7:65444356 GUSB 0.49 7.2 0.37 4.01e-12 Aortic root size; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg14842398 chr16:85645310 KIAA0182 0.53 7.53 0.38 4.82e-13 Response to antipsychotic treatment; CRC cis rs7119 0.651 rs8025968 chr15:77839616 C/T cg27398640 chr15:77910606 LINGO1 -0.44 -7.33 -0.37 1.85e-12 Type 2 diabetes; CRC cis rs1550582 1.000 rs4909827 chr8:135517576 C/T cg17885191 chr8:135476712 NA 0.71 8.28 0.42 3.1e-15 Educational attainment; CRC cis rs6541297 0.938 rs1555289 chr1:230292499 C/T cg05784532 chr1:230284198 GALNT2 -0.46 -5.92 -0.31 8.06e-9 Coronary artery disease; CRC cis rs58804349 0.685 rs11239855 chr10:43483879 A/G cg08461752 chr10:43522343 NA 0.95 8.57 0.43 4.01e-16 Pediatric bone mineral content (radius); CRC cis rs1555895 0.656 rs1536338 chr10:838378 C/T cg10556349 chr10:835070 NA 0.37 7.21 0.37 3.84e-12 Survival in rectal cancer; CRC cis rs8067545 0.611 rs2703781 chr17:20144714 A/G cg13482628 chr17:19912719 NA -0.47 -7.38 -0.38 1.29e-12 Schizophrenia; CRC cis rs73206853 0.764 rs61227741 chr12:110598319 G/T cg12870014 chr12:110450643 ANKRD13A 0.79 8.0 0.4 2.21e-14 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC cis rs12142240 0.698 rs6667861 chr1:46815749 T/C cg00530320 chr1:46809349 NSUN4 0.57 7.75 0.39 1.19e-13 Menopause (age at onset); CRC cis rs7772486 0.743 rs111332144 chr6:146056681 C/T cg23711669 chr6:146136114 FBXO30 -0.65 -10.95 -0.52 5.36e-24 Lobe attachment (rater-scored or self-reported); CRC cis rs2404602 0.692 rs12594556 chr15:77165363 G/A cg22467129 chr15:76604101 ETFA -0.38 -6.07 -0.32 3.61e-9 Blood metabolite levels; CRC cis rs79387448 0.626 rs80277428 chr2:103080056 G/A cg09003973 chr2:102972529 NA 0.89 8.3 0.42 2.68e-15 Gut microbiota (bacterial taxa); CRC cis rs11785400 1.000 rs4518642 chr8:143737396 T/C cg24634471 chr8:143751801 JRK 0.52 7.43 0.38 9.62e-13 Schizophrenia; CRC cis rs3091242 0.809 rs660129 chr1:25727438 C/T cg23205692 chr1:25664452 TMEM50A 0.4 5.66 0.3 3.28e-8 Erythrocyte sedimentation rate; CRC cis rs9348721 0.673 rs9358934 chr6:26363755 G/C cg16898833 chr6:26189333 HIST1H4D 0.76 6.58 0.34 1.84e-10 Intelligence (multi-trait analysis); CRC trans rs200113 0.947 rs200075 chr5:8667441 C/T cg26233084 chr5:15510258 FBXL7 -0.48 -5.98 -0.31 5.94e-9 Uric acid levels; CRC trans rs1814175 0.645 rs1851850 chr11:50012168 G/A cg15704280 chr7:45808275 SEPT13 -0.94 -17.25 -0.69 6.17e-48 Height; CRC cis rs1799949 1.000 rs16942 chr17:41244000 T/C cg01879757 chr17:41196368 BRCA1 -0.43 -6.54 -0.34 2.33e-10 Menopause (age at onset); CRC cis rs4716602 0.550 rs12672151 chr7:156159053 A/G cg16983916 chr7:156159713 NA -0.39 -6.97 -0.36 1.72e-11 Anti-saccade response; CRC cis rs4713118 0.515 rs9368549 chr6:28050047 T/A cg15845792 chr6:28175446 NA 0.97 13.15 0.59 4.96e-32 Parkinson's disease; CRC cis rs2836974 0.897 rs4817996 chr21:40525759 G/C cg11890956 chr21:40555474 PSMG1 1.1 21.14 0.76 3.07e-63 Cognitive function; CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg14103574 chr5:162932455 MAT2B -0.5 -5.98 -0.31 5.85e-9 Diisocyanate-induced asthma; CRC cis rs17401966 0.928 rs11121531 chr1:10277357 G/A cg19773385 chr1:10388646 KIF1B -0.55 -7.5 -0.38 5.95e-13 Hepatocellular carcinoma; CRC cis rs13064411 0.542 rs11537650 chr3:113222036 G/A cg18753928 chr3:113234510 CCDC52 -0.53 -8.13 -0.41 8.8e-15 Response to simvastatin treatment (PCSK9 protein level change); CRC cis rs7945705 0.747 rs2742480 chr11:8993130 A/G cg21881798 chr11:8931708 C11orf17;ST5 -0.65 -10.88 -0.51 9.3e-24 Hemoglobin concentration; CRC cis rs2204008 0.811 rs4882300 chr12:38415224 A/T cg13010199 chr12:38710504 ALG10B -0.46 -6.53 -0.34 2.5e-10 Bladder cancer; CRC trans rs10784762 1.000 rs10784762 chr12:69523923 C/T cg27455578 chr7:86850357 C7orf23 -0.3 -6.26 -0.33 1.17e-9 QRS duration; CRC cis rs853679 0.546 rs200952 chr6:27836976 C/T cg03623178 chr6:28175578 NA 0.78 6.65 0.34 1.22e-10 Depression; CRC cis rs5758511 0.680 rs5758687 chr22:42656588 A/T cg00645731 chr22:42541494 CYP2D7P1 0.64 9.63 0.47 1.67e-19 Birth weight; CRC cis rs1552244 0.572 rs68121641 chr3:10165845 T/A cg08888203 chr3:10149979 C3orf24 0.71 8.57 0.43 4.18e-16 Alzheimer's disease; CRC cis rs8180040 0.902 rs73081205 chr3:47517670 A/C cg10298567 chr3:47292165 KIF9 0.39 6.33 0.33 8.13e-10 Colorectal cancer; CRC cis rs2290159 0.800 rs59821954 chr3:12687613 T/C cg23032965 chr3:12705835 RAF1 0.5 6.39 0.33 5.55e-10 Cholesterol, total; CRC cis rs13191362 1.000 rs2156257 chr6:163100710 G/T cg14584255 chr6:163149320 PACRG;PARK2 0.44 6.39 0.33 5.65e-10 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg22489740 chr19:13991002 NANOS3 0.5 7.08 0.36 8.78e-12 Response to antipsychotic treatment; CRC trans rs2303319 0.504 rs961421 chr2:162626099 G/C cg14875682 chr5:52083620 ITGA1;PELO -0.73 -6.12 -0.32 2.59e-9 Cognitive function; CRC cis rs10208940 0.920 rs7580719 chr2:68833572 A/G cg12452813 chr2:68675892 NA -0.48 -6.07 -0.32 3.48e-9 Urate levels in lean individuals; CRC cis rs2153535 0.580 rs6941670 chr6:8446346 G/A cg21535247 chr6:8435926 SLC35B3 0.5 7.62 0.39 2.73e-13 Motion sickness; CRC cis rs35883536 0.647 rs17402665 chr1:101046940 C/T cg06223162 chr1:101003688 GPR88 -0.34 -6.15 -0.32 2.21e-9 Monocyte count; CRC cis rs7843479 0.601 rs4422769 chr8:21844265 A/G cg17168535 chr8:21777572 XPO7 0.62 10.45 0.5 3.01e-22 Mean corpuscular volume; CRC cis rs2032447 0.966 rs3752416 chr6:26045929 T/C cg12310025 chr6:25882481 NA -0.45 -6.39 -0.33 5.71e-10 Intelligence (multi-trait analysis); CRC cis rs3857067 1.000 rs7682116 chr4:95002704 T/C cg11021082 chr4:95130006 SMARCAD1 -0.4 -6.04 -0.32 4.06e-9 QT interval; CRC cis rs933688 1.000 rs1895448 chr5:90743854 C/T cg26981201 chr5:90679533 LOC100129716;ARRDC3 1.02 16.76 0.68 5.02e-46 Smoking behavior; CRC cis rs10256972 0.616 rs4585652 chr7:1145396 A/G cg07092213 chr7:1199455 ZFAND2A -0.44 -6.16 -0.32 2.15e-9 Longevity;Endometriosis; CRC cis rs9902453 1.000 rs9902453 chr17:28349095 C/T cg26525008 chr17:28256777 EFCAB5;SSH2 -0.59 -8.83 -0.44 6.17e-17 Coffee consumption (cups per day); CRC trans rs7618501 1.000 rs11716575 chr3:49744890 A/G cg21582582 chr3:182698605 DCUN1D1 -0.56 -8.25 -0.41 3.82e-15 Intelligence (multi-trait analysis); CRC cis rs1843834 0.858 rs2047136 chr2:225511361 A/T cg22455342 chr2:225449267 CUL3 0.48 6.77 0.35 5.86e-11 IgE levels in asthmatics (D.p. specific); CRC cis rs9611565 0.592 rs5751139 chr22:42099981 G/C cg06481639 chr22:41940642 POLR3H 0.51 5.81 0.31 1.45e-8 Vitiligo; CRC cis rs4555082 0.957 rs2816608 chr14:105718407 A/G cg13114125 chr14:105738426 BRF1 0.72 11.24 0.53 4.9e-25 Mean platelet volume;Platelet distribution width; CRC cis rs10464366 0.571 rs4723825 chr7:39157627 G/C cg21665744 chr7:39171113 POU6F2 0.45 5.96 0.31 6.67e-9 IgG glycosylation; CRC cis rs12042938 0.600 rs1094655 chr1:231774362 A/G cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX 0.5 6.94 0.36 2.14e-11 Neuranatomic and neurocognitive phenotypes; CRC trans rs1814175 0.935 rs6485999 chr11:49658986 G/C cg03929089 chr4:120376271 NA -0.93 -17.05 -0.68 3.89e-47 Height; CRC cis rs2276314 0.857 rs3737474 chr18:33613595 T/C cg05985134 chr18:33552581 C18orf21 0.5 6.5 0.34 2.91e-10 Endometriosis;Drug-induced torsades de pointes; CRC cis rs6500602 0.673 rs4786512 chr16:4573040 A/G cg08645402 chr16:4508243 NA 0.61 9.53 0.46 3.7e-19 Schizophrenia; CRC cis rs1797081 0.542 rs2603796 chr10:16871456 C/T cg23933602 chr10:16859644 RSU1 0.59 8.51 0.42 6.14e-16 Platelet distribution width; CRC cis rs4601821 1.000 rs4601821 chr11:113250346 A/G cg14159747 chr11:113255604 NA 0.5 9.39 0.46 1.03e-18 Alcoholic chronic pancreatitis; CRC cis rs9926296 0.609 rs4785709 chr16:89796665 G/A cg04287289 chr16:89883240 FANCA -0.55 -8.35 -0.42 1.87e-15 Vitiligo; CRC trans rs4130344 0.595 rs7675394 chr4:159863649 T/C cg04008429 chr3:160167646 TRIM59 0.4 5.98 0.31 5.72e-9 Intelligence (multi-trait analysis); CRC cis rs8031584 0.918 rs61997138 chr15:31270776 C/T cg14829155 chr15:31115871 NA -0.5 -8.02 -0.4 1.85e-14 Huntington's disease progression; CRC cis rs600806 0.888 rs3853501 chr1:109864374 G/A cg23032129 chr1:109941072 SORT1 -0.28 -6.04 -0.32 4.16e-9 Intelligence (multi-trait analysis); CRC cis rs10221833 0.636 rs355891 chr2:165634983 T/C cg03182029 chr2:165697222 COBLL1 0.52 6.09 0.32 3.22e-9 Response to statin therapy; CRC cis rs10256972 0.786 rs3735686 chr7:1062527 G/A cg04025307 chr7:1156635 C7orf50 0.46 6.91 0.36 2.46e-11 Longevity;Endometriosis; CRC cis rs801193 0.569 rs3846973 chr7:66120035 T/C cg11764359 chr7:65958608 NA -0.59 -8.69 -0.43 1.7e-16 Aortic root size; CRC cis rs3087591 0.960 rs12942479 chr17:29461912 T/A cg24425628 chr17:29625626 OMG;NF1 0.88 16.69 0.68 9.63e-46 Hip circumference; CRC cis rs7927771 1.000 rs12363232 chr11:47623890 C/T cg20307385 chr11:47447363 PSMC3 -0.55 -7.65 -0.39 2.21e-13 Subjective well-being; CRC cis rs3733585 0.673 rs7378340 chr4:9955198 C/T cg00071950 chr4:10020882 SLC2A9 -0.53 -9.4 -0.46 9.34e-19 Cleft plate (environmental tobacco smoke interaction); CRC cis rs4689592 0.546 rs10937782 chr4:7057106 G/C cg19539972 chr4:7069911 GRPEL1 0.76 10.03 0.48 7.73e-21 Monocyte percentage of white cells; CRC trans rs66573146 0.831 rs67315413 chr4:6987910 T/C cg07817883 chr1:32538562 TMEM39B 1.32 12.64 0.57 3.95e-30 Granulocyte percentage of myeloid white cells; CRC cis rs4073416 0.508 rs10152007 chr14:66047434 A/T cg03016385 chr14:66212404 NA -0.46 -6.25 -0.33 1.31e-9 N-glycan levels; CRC cis rs7224685 0.569 rs34357603 chr17:4008760 G/A cg09695851 chr17:3907499 NA 0.52 6.45 0.33 4.05e-10 Type 2 diabetes; CRC cis rs7615952 0.599 rs2270986 chr3:125701099 T/C cg06494592 chr3:125709126 NA -0.55 -6.57 -0.34 2e-10 Blood pressure (smoking interaction); CRC cis rs1511802 0.666 rs3817184 chr4:187122304 C/T cg24794857 chr4:187113578 CYP4V2 0.39 5.74 0.3 2.15e-8 Blood protein levels; CRC cis rs7201929 0.801 rs9933198 chr16:28888409 C/T cg10436792 chr16:28889110 ATP2A1 0.42 5.94 0.31 7.1e-9 QT interval; CRC cis rs7904368 0.806 rs1130684 chr10:16859335 C/G cg23933602 chr10:16859644 RSU1 0.59 6.77 0.35 5.92e-11 Ratio of the peak velocity of the mitral E-Wave divided by the peak velocity of the mitral A-wave.; CRC cis rs9914544 1.000 rs9916245 chr17:18766825 C/G cg26306683 chr17:18585705 ZNF286B 0.49 6.92 0.36 2.32e-11 Educational attainment (years of education); CRC cis rs17270561 0.583 rs9393661 chr6:25739080 C/T cg17691542 chr6:26056736 HIST1H1C 0.73 9.26 0.45 2.71e-18 Iron status biomarkers; CRC cis rs4665809 0.531 rs12987980 chr2:26462093 A/T cg26119090 chr2:26468346 HADHA;HADHB 1.06 15.53 0.65 3.62e-41 Gut microbiome composition (summer); CRC cis rs2249694 0.960 rs2515642 chr10:135352013 C/T cg20169779 chr10:135381914 SYCE1 0.54 8.67 0.43 1.93e-16 Obesity-related traits; CRC cis rs8180040 0.615 rs13062681 chr3:47021124 A/G cg27129171 chr3:47204927 SETD2 0.65 10.27 0.49 1.21e-21 Colorectal cancer; CRC cis rs713587 0.967 rs10182458 chr2:25150641 A/G cg22495460 chr2:25135724 ADCY3 -0.75 -13.67 -0.6 5.51e-34 Body mass index in non-asthmatics; CRC cis rs6840360 0.762 rs62327352 chr4:152670780 C/A cg09659197 chr4:152720779 NA 0.54 11.79 0.55 5.22e-27 Intelligence (multi-trait analysis); CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg10353859 chr19:39109696 MAP4K1;EIF3K 0.45 6.36 0.33 6.81e-10 Anxiety disorder; CRC cis rs9303280 0.806 rs12232498 chr17:38040363 T/C cg00129232 chr17:37814104 STARD3 -0.43 -6.9 -0.36 2.67e-11 Self-reported allergy; CRC cis rs853679 0.517 rs2281588 chr6:28072602 G/A cg15786705 chr6:28176104 NA 0.76 9.63 0.47 1.68e-19 Depression; CRC cis rs270601 0.661 rs10036208 chr5:131571323 T/C cg12564285 chr5:131593104 PDLIM4 0.58 10.31 0.49 8.45e-22 Acylcarnitine levels; CRC cis rs9462027 0.628 rs10947531 chr6:34765118 A/C cg07306190 chr6:34760872 UHRF1BP1 0.34 6.07 0.32 3.43e-9 Systemic lupus erythematosus; CRC cis rs12216125 0.537 rs12207059 chr6:25922385 C/T cg17691542 chr6:26056736 HIST1H1C 0.91 10.97 0.52 4.52e-24 Iron status biomarkers; CRC cis rs780094 0.544 rs780108 chr2:27684957 T/C cg12648201 chr2:27665141 KRTCAP3 -0.28 -5.61 -0.3 4.32e-8 Calcium levels;Fasting blood insulin;Metabolic traits;Triglyceride levels;Fasting plasma glucose;Urate levels in overweight individuals;Urate levels in obese individuals;Uric acid levels;Height;Age-related diseases, mortality and associated endophenotypes;Renal underexcretion gout;Fasting blood glucose (BMI interaction);Urate levels;Gondoic acid (20:1n-9) levels;Fasting blood insulin (BMI interaction);Triglycerides;Plasma omega-3 polyunsaturated fatty acid levels (docosapentaenoic acid);Type 2 diabetes;Nonalcoholic fatty liver disease;Hypertriglyceridemia;C-reactive protein;Age-related disease endophenotypes;LDL cholesterol;Metabolic syndrome;Crohn's disease;Alcohol consumption (drinks per week);Homeostasis model assessment of insulin resistance;Alcohol consumption;Red blood cell count;Fasting blood glucose; CRC cis rs11764590 0.666 rs3996325 chr7:2053747 T/C cg14004847 chr7:1930337 MAD1L1 -0.46 -5.92 -0.31 8.27e-9 Neuroticism; CRC trans rs7824557 0.527 rs4631425 chr8:11239054 C/T cg06636001 chr8:8085503 FLJ10661 -0.44 -6.54 -0.34 2.31e-10 Retinal vascular caliber; CRC cis rs8077889 0.871 rs7212648 chr17:41917962 A/C cg26893861 chr17:41843967 DUSP3 0.91 11.89 0.55 2.22e-27 Triglycerides; CRC cis rs10504229 0.639 rs11781834 chr8:58133422 C/T cg02725872 chr8:58115012 NA -0.64 -11.25 -0.53 4.63e-25 Developmental language disorder (linguistic errors); CRC cis rs1552244 1.000 rs113522867 chr3:10154503 T/C cg10729496 chr3:10149963 C3orf24 0.54 7.0 0.36 1.41e-11 Alzheimer's disease; CRC cis rs1109861 0.557 rs2399664 chr10:11244173 G/A cg24910943 chr10:11206320 CUGBP2 -0.27 -6.83 -0.35 4.18e-11 Urinary albumin-to-creatinine ratio; CRC cis rs7481584 0.624 rs375579 chr11:3065300 G/C cg25174290 chr11:3078921 CARS -0.43 -5.98 -0.31 5.95e-9 Calcium levels; CRC cis rs782590 0.934 rs62165184 chr2:55788253 G/C cg18811423 chr2:55921094 PNPT1 0.8 14.67 0.63 8.01e-38 Metabolic syndrome; CRC cis rs5758511 0.633 rs5758689 chr22:42664972 T/G cg00645731 chr22:42541494 CYP2D7P1 0.63 9.68 0.47 1.13e-19 Birth weight; CRC cis rs7216064 0.953 rs10445361 chr17:65962238 G/T cg12091567 chr17:66097778 LOC651250 0.57 6.87 0.35 3.23e-11 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CRC cis rs274567 0.501 rs272856 chr5:131687081 G/C cg20512303 chr5:131592959 PDLIM4 0.4 6.62 0.34 1.43e-10 Blood metabolite levels; CRC cis rs7586879 0.681 rs28836469 chr2:25117215 A/G cg04586622 chr2:25135609 ADCY3 -0.55 -10.2 -0.49 2.06e-21 Body mass index; CRC trans rs7615952 0.546 rs2979350 chr3:125362215 T/C cg00769240 chr8:12517080 NA -0.68 -7.78 -0.39 9.14e-14 Blood pressure (smoking interaction); CRC cis rs422249 0.511 rs102274 chr11:61557826 T/C cg00603274 chr11:61596626 FADS2 -0.44 -6.44 -0.33 4.2e-10 Trans fatty acid levels; CRC cis rs12024301 0.557 rs6671085 chr1:183602532 G/A cg11505048 chr1:183622726 RGL1;APOBEC4 0.75 6.81 0.35 4.6e-11 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs6547741 1.000 rs6750943 chr2:27777904 T/G cg27432699 chr2:27873401 GPN1 0.75 13.33 0.59 1.05e-32 Oral cavity cancer; CRC cis rs6456156 0.586 rs911632 chr6:167471461 T/C cg07741184 chr6:167504864 NA 0.39 6.85 0.35 3.66e-11 Primary biliary cholangitis; CRC cis rs9326248 0.953 rs634960 chr11:117072963 T/C cg10130564 chr11:117069849 TAGLN -0.38 -6.92 -0.36 2.36e-11 Blood protein levels; CRC cis rs9910055 0.960 rs9911991 chr17:42278916 G/C cg10896456 chr17:42255109 ASB16;C17orf65 0.45 7.19 0.37 4.46e-12 Total body bone mineral density; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg05218490 chr2:148778969 ORC4L 0.45 6.18 0.32 1.91e-9 Response to antipsychotic treatment; CRC cis rs6120849 0.754 rs752448 chr20:33592248 C/T cg08999081 chr20:33150536 PIGU 0.46 5.88 0.31 9.91e-9 Protein C levels; CRC cis rs11971779 0.680 rs4077889 chr7:139033914 A/G cg07862535 chr7:139043722 LUC7L2 0.57 7.35 0.38 1.55e-12 Diisocyanate-induced asthma; CRC cis rs6951245 1.000 rs2363286 chr7:1091625 A/G cg22907277 chr7:1156413 C7orf50 0.62 6.63 0.34 1.35e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC trans rs12699921 0.598 rs2723504 chr7:17854833 T/A cg02066331 chr6:17282778 RBM24 -0.35 -6.1 -0.32 2.9e-9 Fibrinogen levels; CRC cis rs4731207 0.570 rs7784616 chr7:124677194 C/G cg23710748 chr7:124431027 NA -0.39 -6.18 -0.32 1.94e-9 Cutaneous malignant melanoma; CRC cis rs6500395 1.000 rs9925406 chr16:48671436 C/A cg04672837 chr16:48644449 N4BP1 0.45 6.73 0.35 7.64e-11 Response to tocilizumab in rheumatoid arthritis; CRC cis rs11764590 0.671 rs56226325 chr7:2078981 C/T cg13880726 chr7:1868755 MAD1L1 -0.48 -5.78 -0.3 1.76e-8 Neuroticism; CRC cis rs17818399 0.547 rs62134736 chr2:46766446 G/A cg21681030 chr2:46777652 RHOQ 0.44 5.81 0.3 1.51e-8 Height; CRC cis rs875971 1.000 rs12532998 chr7:65967459 A/C cg18912574 chr7:65842487 NCRNA00174 0.35 6.07 0.32 3.6e-9 Aortic root size; CRC trans rs9929218 0.906 rs4783565 chr16:68750190 G/A cg04657470 chr2:198365150 HSPE1;HSPD1 -0.99 -14.55 -0.63 2.15e-37 Colorectal cancer; CRC cis rs1862618 0.671 rs2591955 chr5:56244948 C/T cg18230493 chr5:56204884 C5orf35 0.6 8.95 0.44 2.64e-17 Initial pursuit acceleration; CRC trans rs9929218 0.539 rs1125557 chr16:68809599 G/A cg04657470 chr2:198365150 HSPE1;HSPD1 0.91 15.85 0.66 1.97e-42 Colorectal cancer; CRC cis rs4727027 0.933 rs12667123 chr7:148850621 G/A cg23583168 chr7:148888333 NA -0.93 -16.25 -0.67 5.44e-44 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC cis rs7223966 1.000 rs7220892 chr17:61908316 G/A cg05941027 chr17:61774174 LIMD2 0.36 6.46 0.34 3.76e-10 Hip circumference adjusted for BMI;Body mass index; CRC cis rs853679 0.517 rs9368554 chr6:28082711 T/C cg15845792 chr6:28175446 NA 1.0 13.1 0.59 7.81e-32 Depression; CRC cis rs79839061 0.610 rs11726280 chr4:864077 C/T cg14530993 chr4:882597 GAK 0.84 7.94 0.4 3.18e-14 Intelligence (multi-trait analysis); CRC cis rs6502050 0.731 rs34796376 chr17:80116635 G/T cg02741985 chr17:80059408 CCDC57 0.43 7.18 0.37 4.68e-12 Life satisfaction; CRC cis rs501916 0.634 rs1045688 chr15:48065487 A/G cg16110827 chr15:48056943 SEMA6D 0.45 6.63 0.34 1.4e-10 Inflammatory bowel disease;Ulcerative colitis; CRC cis rs651907 0.514 rs10936744 chr3:101433440 C/T cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.6 8.08 0.41 1.21e-14 Colorectal cancer; CRC cis rs1832871 0.711 rs9459904 chr6:158700982 C/T cg07165851 chr6:158734300 TULP4 0.6 7.59 0.39 3.38e-13 Height; CRC cis rs9457247 0.624 rs17524252 chr6:167466978 T/G cg07741184 chr6:167504864 NA 0.44 7.42 0.38 1.02e-12 Crohn's disease; CRC cis rs2839186 0.814 rs2839167 chr21:47661587 A/G cg13126279 chr21:47581558 C21orf56 -0.5 -8.06 -0.41 1.42e-14 Testicular germ cell tumor; CRC cis rs7666738 0.830 rs1025204 chr4:99023441 G/A cg05340658 chr4:99064831 C4orf37 0.61 9.4 0.46 9.44e-19 Colonoscopy-negative controls vs population controls; CRC cis rs6540556 0.521 rs9430015 chr1:209911734 G/A cg23920097 chr1:209922102 NA -0.49 -6.07 -0.32 3.61e-9 Red blood cell count; CRC cis rs7568458 0.709 rs2592551 chr2:85780131 G/A cg02493740 chr2:85810744 VAMP5 -0.55 -8.3 -0.42 2.75e-15 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); CRC cis rs56399783 0.901 rs73049341 chr7:2812255 G/C cg19731401 chr7:2775893 GNA12 0.57 6.3 0.33 9.37e-10 Childhood ear infection; CRC cis rs9916302 0.904 rs4511574 chr17:37532916 A/G cg03013999 chr17:37608204 MED1 0.45 7.04 0.36 1.1e-11 Glomerular filtration rate (creatinine); CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg05298461 chr20:33999889 UQCC 0.45 5.97 0.31 6.21e-9 Anxiety disorder; CRC cis rs1003719 0.628 rs2252402 chr21:38520720 A/G cg10648535 chr21:38446584 PIGP;TTC3 0.42 5.72 0.3 2.37e-8 Eye color traits; CRC cis rs4665809 1.000 rs4665309 chr2:26335502 T/C cg26119090 chr2:26468346 HADHA;HADHB -0.61 -7.88 -0.4 4.97e-14 Gut microbiome composition (summer); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg04241444 chr20:43594850 STK4 0.47 6.78 0.35 5.6e-11 Response to antipsychotic treatment; CRC cis rs7191439 0.728 rs8043637 chr16:88781125 T/C cg02389323 chr16:88786976 FAM38A 0.91 8.39 0.42 1.43e-15 Plateletcrit; CRC cis rs2797160 1.000 rs2747719 chr6:126009214 C/T cg05901451 chr6:126070800 HEY2 0.4 6.2 0.32 1.65e-9 Endometrial cancer; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg13937449 chr12:56320970 WIBG 0.43 6.07 0.32 3.51e-9 Response to antipsychotic treatment; CRC cis rs2549003 0.870 rs61175929 chr5:131821548 C/G cg21138405 chr5:131827807 IRF1 0.57 11.38 0.53 1.59e-25 Asthma (sex interaction); CRC cis rs902774 0.585 rs7399070 chr12:53355678 G/T cg05393297 chr12:53359155 NA -1.06 -10.26 -0.49 1.26e-21 Prostate cancer; CRC cis rs7811142 0.720 rs112622797 chr7:99917416 G/A cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.55 6.51 0.34 2.78e-10 Platelet count; CRC trans rs6951245 1.000 rs77702926 chr7:1088838 G/A cg13565492 chr6:43139072 SRF -0.71 -7.12 -0.37 7.03e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs11761441 0.602 rs6979396 chr7:93116 G/A cg12845006 chr7:82380 NA -0.23 -5.79 -0.3 1.69e-8 Alzheimer's disease in APOE e4- carriers; CRC cis rs1799949 1.000 rs11653253 chr17:41182662 G/A cg25072359 chr17:41440525 NA 0.47 6.92 0.36 2.32e-11 Menopause (age at onset); CRC cis rs12497850 0.864 rs4513485 chr3:49139966 G/A cg07636037 chr3:49044803 WDR6 0.97 15.9 0.66 1.27e-42 Parkinson's disease; CRC cis rs7762018 1.000 rs1127489 chr6:170107702 C/T cg19338460 chr6:170058176 WDR27 -0.74 -8.01 -0.4 1.97e-14 Thiazide-induced adverse metabolic effects in hypertensive patients; CRC cis rs10751667 1.000 rs7394449 chr11:962190 T/C ch.11.42038R chr11:967971 AP2A2 0.69 11.74 0.54 8.24e-27 Alzheimer's disease (late onset); CRC cis rs311392 1.000 rs454064 chr8:55088336 C/T cg06042504 chr8:55087323 NA -0.43 -6.58 -0.34 1.88e-10 Pelvic organ prolapse (moderate/severe); CRC cis rs2412459 1.000 rs2279581 chr15:40300092 A/G cg20255370 chr15:40268687 EIF2AK4 -0.66 -6.63 -0.34 1.35e-10 Response to haloperidol in psychosis; CRC cis rs10504229 0.683 rs72649192 chr8:58110490 T/C cg22535103 chr8:58192502 C8orf71 -0.72 -8.12 -0.41 9.42e-15 Developmental language disorder (linguistic errors); CRC cis rs791888 0.929 rs2755431 chr10:89415104 C/T cg13926569 chr10:89418898 PAPSS2 -0.45 -6.59 -0.34 1.75e-10 Magnesium levels; CRC cis rs1862618 0.853 rs832553 chr5:56114786 A/G cg03609598 chr5:56110824 MAP3K1 -0.83 -10.31 -0.49 8.84e-22 Initial pursuit acceleration; CRC cis rs4665809 0.590 rs4665315 chr2:26416036 T/G cg27170947 chr2:26402098 FAM59B -0.59 -7.62 -0.39 2.79e-13 Gut microbiome composition (summer); CRC cis rs2227564 0.729 rs2227551 chr10:75669190 G/T cg00564723 chr10:75632066 CAMK2G -0.28 -6.52 -0.34 2.6200000000000003e-10 Crohn's disease;Inflammatory bowel disease; CRC cis rs752010 1.000 rs6656183 chr1:42094025 A/G cg06885757 chr1:42089581 HIVEP3 0.49 8.51 0.42 6.42e-16 Lupus nephritis in systemic lupus erythematosus; CRC cis rs72615157 0.561 rs113844570 chr7:99873778 A/C cg07160278 chr7:100027354 MEPCE;ZCWPW1 0.77 8.89 0.44 4.09e-17 Lung function (FEV1/FVC); CRC cis rs7927592 0.913 rs55883802 chr11:68278829 G/A cg01657329 chr11:68192670 LRP5 -0.46 -6.48 -0.34 3.28e-10 Total body bone mineral density; CRC cis rs1865760 0.865 rs9393677 chr6:25945815 G/A cg16482183 chr6:26056742 HIST1H1C 0.52 7.37 0.38 1.41e-12 Height; CRC cis rs10857712 0.904 rs7083614 chr10:135226236 G/A cg19623624 chr10:135278901 LOC619207 -0.4 -6.41 -0.33 4.91e-10 Systemic lupus erythematosus; CRC cis rs1451375 1.000 rs921450 chr7:50623260 A/G cg18232548 chr7:50535776 DDC -0.46 -6.52 -0.34 2.57e-10 Malaria; CRC cis rs4141404 0.828 rs2413043 chr22:31648576 G/T cg22777020 chr22:31556080 RNF185 -0.53 -6.14 -0.32 2.34e-9 Paclitaxel-induced neuropathy; CRC cis rs875971 1.000 rs2042133 chr7:65931922 A/G cg11764359 chr7:65958608 NA 0.62 9.91 0.48 1.96e-20 Aortic root size; CRC cis rs3785574 0.962 rs2584628 chr17:61894578 T/C cg22520471 chr17:61851767 DDX42;CCDC47 0.45 6.13 0.32 2.48e-9 Height; CRC cis rs847577 0.630 rs2132276 chr7:97826340 G/A cg24562669 chr7:97807699 LMTK2 0.79 17.64 0.7 1.72e-49 Breast cancer; CRC cis rs7849270 1.000 rs10819471 chr9:131896325 A/C cg13538475 chr9:131942899 NA -0.31 -6.28 -0.33 1.05e-9 Blood metabolite ratios; CRC cis rs12893668 0.673 rs2296482 chr14:104029819 T/G cg08213375 chr14:104286397 PPP1R13B 0.37 5.65 0.3 3.39e-8 Reticulocyte count; CRC trans rs2797160 1.000 rs9321050 chr6:126001568 A/G cg05039488 chr6:79577232 IRAK1BP1 -0.49 -7.2 -0.37 4.21e-12 Endometrial cancer; CRC cis rs13108904 0.935 rs1732100 chr4:1281761 C/T cg20887711 chr4:1340912 KIAA1530 -0.48 -7.16 -0.37 5.34e-12 Obesity-related traits; CRC cis rs17818399 0.548 rs1989720 chr2:46854364 C/T cg26688816 chr2:46740690 ATP6V1E2 -0.43 -6.46 -0.34 3.88e-10 Height; CRC trans rs7829975 0.840 rs572366 chr8:8578794 A/T cg16141378 chr3:129829833 LOC729375 -0.42 -6.26 -0.33 1.2e-9 Mood instability; CRC cis rs6499255 0.951 rs61310815 chr16:69701239 A/T cg15192750 chr16:69999425 NA 0.55 7.42 0.38 9.78e-13 IgE levels; CRC cis rs12410462 0.582 rs2872251 chr1:227647723 G/A cg04117972 chr1:227635322 NA 0.67 7.6 0.39 3.08e-13 Major depressive disorder; CRC cis rs9916302 0.706 rs1054488 chr17:37687968 A/G cg20243544 chr17:37824526 PNMT 0.47 5.6 0.3 4.45e-8 Glomerular filtration rate (creatinine); CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg07962812 chr1:183441443 SMG7 0.46 6.2 0.32 1.67e-9 Anxiety disorder; CRC cis rs7618501 0.633 rs55751738 chr3:49972101 A/G cg05623727 chr3:50126028 RBM5 0.45 7.66 0.39 2.06e-13 Intelligence (multi-trait analysis); CRC cis rs155076 1.000 rs261404 chr13:21858162 T/G cg25811766 chr13:21894605 NA -0.53 -5.76 -0.3 1.92e-8 White matter hyperintensity burden; CRC trans rs7976838 0.908 rs35889150 chr12:60143798 G/T cg16974014 chr22:22007515 MIR130B 0.49 6.0 0.31 5.21e-9 Response to zileuton treatment in asthma (FEV1 change interaction); CRC cis rs992157 0.700 rs10165153 chr2:219159629 T/C cg13835894 chr2:219148914 PNKD;TMBIM1 0.33 6.31 0.33 8.82e-10 Colorectal cancer; CRC cis rs10484885 0.878 rs72921916 chr6:90555990 C/T cg13799429 chr6:90582589 CASP8AP2 -0.72 -7.69 -0.39 1.76e-13 QRS interval (sulfonylurea treatment interaction); CRC cis rs9914988 0.943 rs4794838 chr17:27131095 T/C cg07195577 chr17:27052828 TLCD1 0.42 6.02 0.32 4.64e-9 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs28386778 0.897 rs11079510 chr17:61820902 T/C cg06873352 chr17:61820015 STRADA 0.75 14.1 0.61 1.27e-35 Prudent dietary pattern; CRC cis rs951366 0.789 rs823095 chr1:205679239 G/A cg07157834 chr1:205819609 PM20D1 0.77 11.27 0.53 3.9e-25 Menarche (age at onset); CRC cis rs1799949 1.000 rs8176109 chr17:41265776 A/G cg19454999 chr17:41278357 BRCA1;NBR2 0.56 8.89 0.44 4.26e-17 Menopause (age at onset); CRC cis rs12024301 0.557 rs7556582 chr1:183645446 A/G cg11505048 chr1:183622726 RGL1;APOBEC4 0.82 6.81 0.35 4.59e-11 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs11971779 0.553 rs10085770 chr7:139100349 G/A cg23387468 chr7:139079360 LUC7L2 0.41 7.05 0.36 1.04e-11 Diisocyanate-induced asthma; CRC cis rs11098499 0.863 rs3733525 chr4:120447048 A/G cg24375607 chr4:120327624 NA 0.46 6.98 0.36 1.64e-11 Corneal astigmatism; CRC cis rs12681288 0.676 rs935820 chr8:1022168 A/G cg15309053 chr8:964076 NA 0.41 7.49 0.38 6.25e-13 Schizophrenia; CRC cis rs4969178 0.965 rs16971107 chr17:76394042 C/T cg05887092 chr17:76393375 PGS1 0.52 9.41 0.46 8.65e-19 HDL cholesterol levels; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg06254406 chr13:103450982 BIVM;KDELC1 0.47 6.91 0.36 2.54e-11 Intelligence (multi-trait analysis); CRC trans rs925098 0.577 rs2724470 chr4:17996046 A/G cg20929922 chr5:43484725 C5orf28 -0.4 -6.01 -0.31 4.92e-9 Birth weight;Height; CRC cis rs365302 1.000 rs823903 chr6:159652445 G/A cg14500486 chr6:159655392 FNDC1 -0.44 -6.82 -0.35 4.31e-11 Coronary heart disease; CRC cis rs1215050 0.904 rs165246 chr4:98688541 C/T cg05340658 chr4:99064831 C4orf37 0.44 6.15 0.32 2.21e-9 Waist-to-hip ratio adjusted for body mass index; CRC cis rs853679 1.000 rs6901575 chr6:28250984 G/A cg12273811 chr6:28175739 NA 0.54 5.62 0.3 4.04e-8 Depression; CRC cis rs7618915 0.547 rs6762813 chr3:52726695 C/T cg05573699 chr3:52720067 GNL3;PBRM1 -0.44 -6.26 -0.33 1.17e-9 Bipolar disorder; CRC cis rs12600856 1 rs12600856 chr17:38163295 T/C cg17467752 chr17:38218738 THRA 0.73 12.0 0.55 9.38e-28 Sum neutrophil eosinophil counts;Sum basophil neutrophil counts;White blood cell count;Granulocyte count;Neutrophil count;Myeloid white cell count; CRC cis rs17095355 1.000 rs12259261 chr10:111725145 A/G cg00817464 chr10:111662876 XPNPEP1 -0.63 -8.56 -0.43 4.5e-16 Biliary atresia; CRC cis rs9443645 0.901 rs2050659 chr6:79734369 A/C cg09184832 chr6:79620586 NA -0.51 -9.2 -0.45 4.29e-18 Intelligence (multi-trait analysis); CRC cis rs7727544 0.647 rs72793280 chr5:131562900 C/T cg02033258 chr5:131593261 PDLIM4 0.36 6.66 0.34 1.13e-10 Blood metabolite levels; CRC cis rs911119 0.913 rs6036461 chr20:23576754 C/G cg16589663 chr20:23618590 CST3 0.42 6.09 0.32 3.19e-9 Chronic kidney disease; CRC cis rs10870270 1.000 rs10430617 chr10:133748889 T/C cg08754478 chr10:133766260 PPP2R2D -0.68 -9.88 -0.48 2.56e-20 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; CRC cis rs4927850 1.000 rs10881564 chr3:195750326 C/T cg00031303 chr3:195681400 NA 0.49 7.03 0.36 1.2e-11 Pancreatic cancer; CRC cis rs1862618 0.853 rs9283717 chr5:56078659 G/A cg22800045 chr5:56110881 MAP3K1 0.58 6.18 0.32 1.92e-9 Initial pursuit acceleration; CRC cis rs79349575 0.749 rs46521 chr17:46988529 A/G cg00947319 chr17:47005597 UBE2Z -0.34 -5.87 -0.31 1.07e-8 Type 2 diabetes; CRC cis rs727563 0.636 rs2413653 chr22:42106996 T/C cg03806693 chr22:41940476 POLR3H 1.07 13.48 0.6 2.85e-33 Crohn's disease;Inflammatory bowel disease; CRC cis rs7618501 0.633 rs2856234 chr3:50139142 A/G cg05623727 chr3:50126028 RBM5 -0.43 -7.33 -0.37 1.84e-12 Intelligence (multi-trait analysis); CRC cis rs12477438 0.520 rs11123762 chr2:99727789 T/C cg14399236 chr2:99771627 LIPT1;TSGA10 0.82 14.42 0.62 6.95e-37 Chronic sinus infection; CRC cis rs703842 0.616 rs10877023 chr12:58224199 C/A cg00677455 chr12:58241039 CTDSP2 0.84 12.69 0.57 2.67e-30 Multiple sclerosis; CRC cis rs1949733 0.656 rs6845969 chr4:8402465 A/T cg13073564 chr4:8508604 NA -0.46 -7.24 -0.37 3.19e-12 Response to antineoplastic agents; CRC cis rs1451375 1.000 rs2329341 chr7:50620275 A/C cg18232548 chr7:50535776 DDC 0.48 6.82 0.35 4.43e-11 Malaria; CRC cis rs7666738 0.830 rs11941961 chr4:99065654 G/T cg17366294 chr4:99064904 C4orf37 0.42 7.04 0.36 1.15e-11 Colonoscopy-negative controls vs population controls; CRC cis rs2072510 0.569 rs7134975 chr12:96390420 C/A cg09636302 chr12:96389483 HAL -0.52 -6.5 -0.34 3.02e-10 Metabolite levels (small molecules and protein measures); CRC cis rs6545883 0.894 rs2694642 chr2:61596180 A/G cg15711740 chr2:61764176 XPO1 0.43 5.69 0.3 2.76e-8 Tuberculosis; CRC cis rs763121 0.785 rs6001203 chr22:39099602 T/C cg06544989 chr22:39130855 UNC84B 0.48 7.65 0.39 2.27e-13 Menopause (age at onset); CRC cis rs7727544 0.904 rs6897575 chr5:131604535 C/T cg12564285 chr5:131593104 PDLIM4 0.39 7.46 0.38 7.65e-13 Blood metabolite levels; CRC cis rs2455601 1.000 rs12223690 chr11:8901824 G/A cg21881798 chr11:8931708 C11orf17;ST5 -0.55 -5.61 -0.3 4.22e-8 Schizophrenia; CRC cis rs2976388 0.525 rs2016749 chr8:143836118 G/A cg24046110 chr8:143859143 LYNX1 -0.64 -11.29 -0.53 3.22e-25 Urinary tract infection frequency; CRC cis rs853679 0.517 rs12174753 chr6:28042465 C/G cg12273811 chr6:28175739 NA 0.69 8.75 0.43 1.13e-16 Depression; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg10477754 chr10:103892376 PPRC1 0.49 7.03 0.36 1.18e-11 Response to antipsychotic treatment; CRC cis rs9611565 0.729 rs505533 chr22:41864216 A/C cg03806693 chr22:41940476 POLR3H 0.78 11.03 0.52 2.86e-24 Vitiligo; CRC trans rs1997103 1.000 rs1965556 chr7:55403584 C/G cg20935933 chr6:143382018 AIG1 0.51 6.68 0.35 1.03e-10 QRS interval (sulfonylurea treatment interaction); CRC cis rs9527 0.615 rs10883804 chr10:104706520 G/A cg04362960 chr10:104952993 NT5C2 0.6 8.58 0.43 3.83e-16 Arsenic metabolism; CRC cis rs3764400 0.508 rs2240119 chr17:46111172 C/T cg10706073 chr17:46328419 SKAP1 0.66 6.94 0.36 2.16e-11 Body mass index; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg21684385 chr6:143772210 ADAT2;PEX3 0.42 6.0 0.31 5.13e-9 Intelligence (multi-trait analysis); CRC cis rs11148252 0.811 rs9535895 chr13:52765847 G/A cg12458913 chr13:53173898 NA 0.54 8.49 0.42 7.44e-16 Lewy body disease; CRC cis rs11025559 0.812 rs11025583 chr11:20513260 C/T cg19653624 chr11:20408972 PRMT3 0.57 7.19 0.37 4.34e-12 Pursuit maintenance gain; CRC cis rs9908102 0.770 rs73300518 chr17:12914795 G/C cg26162695 chr17:12921313 ELAC2 0.42 5.71 0.3 2.54e-8 Schizophrenia; CRC cis rs7584330 0.868 rs67071074 chr2:238395429 T/C cg16989719 chr2:238392110 NA -0.48 -9.2 -0.45 4.37e-18 Prostate cancer; CRC cis rs1268083 0.546 rs9398785 chr6:126057748 A/G cg05901451 chr6:126070800 HEY2 -0.46 -7.46 -0.38 8e-13 Migraine; CRC cis rs17401966 0.838 rs12141246 chr1:10327407 A/T cg19773385 chr1:10388646 KIF1B -0.64 -10.56 -0.5 1.21e-22 Hepatocellular carcinoma; CRC cis rs8180040 0.966 rs7649234 chr3:47494380 G/C cg02527881 chr3:46936655 PTH1R -0.39 -7.33 -0.37 1.84e-12 Colorectal cancer; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg12107637 chr18:3248148 MYL12A 0.49 6.88 0.35 3.02e-11 Response to antipsychotic treatment; CRC cis rs6860806 0.603 rs112300250 chr5:131583292 G/A cg09877947 chr5:131593287 PDLIM4 0.45 8.41 0.42 1.25e-15 Breast cancer; CRC cis rs4862750 0.794 rs7672272 chr4:187896774 T/G cg11301795 chr4:187892539 NA -0.87 -19.83 -0.74 4.13e-58 Lobe attachment (rater-scored or self-reported); CRC cis rs7705042 0.865 rs249641 chr5:141525305 A/G cg08523384 chr5:141488047 NDFIP1 -0.32 -5.71 -0.3 2.5e-8 Asthma; CRC cis rs9916302 0.904 rs2303316 chr17:37704217 A/G cg15445000 chr17:37608096 MED1 0.39 8.48 0.42 7.93e-16 Glomerular filtration rate (creatinine); CRC cis rs7943203 0.925 rs12223381 chr11:108354102 C/T cg14761454 chr11:108092087 ATM;NPAT 0.39 5.82 0.31 1.37e-8 Red blood cell count;Mean corpuscular volume; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg26679024 chr12:57400033 ZBTB39 0.45 6.63 0.34 1.39e-10 Intelligence (multi-trait analysis); CRC cis rs9916302 0.861 rs8081033 chr17:37506650 A/G cg15445000 chr17:37608096 MED1 -0.44 -9.71 -0.47 9.25e-20 Glomerular filtration rate (creatinine); CRC cis rs12760731 0.623 rs12691480 chr1:178328790 T/A cg00404053 chr1:178313656 RASAL2 0.74 9.32 0.46 1.73e-18 Obesity-related traits; CRC cis rs6951245 0.638 rs4720486 chr7:1146764 G/A cg22907277 chr7:1156413 C7orf50 0.82 10.55 0.5 1.28e-22 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC trans rs747782 0.585 rs1316604 chr11:48279796 G/A cg27395922 chr11:50257633 LOC441601 0.49 6.2 0.32 1.68e-9 Intraocular pressure; CRC cis rs17376456 0.877 rs9314092 chr5:93326362 A/G cg09848695 chr5:92956644 FAM172A;MIR2277 0.63 5.93 0.31 7.49e-9 Diabetic retinopathy; CRC trans rs3733585 0.699 rs7663079 chr4:9966771 T/C cg26043149 chr18:55253948 FECH -0.49 -7.42 -0.38 9.82e-13 Cleft plate (environmental tobacco smoke interaction); CRC trans rs2243480 1.000 rs4718317 chr7:65648901 A/G cg10756647 chr7:56101905 PSPH -0.75 -8.03 -0.4 1.73e-14 Diabetic kidney disease; CRC cis rs2075371 1.000 rs1421485 chr7:133985181 C/T cg11752832 chr7:134001865 SLC35B4 0.5 7.75 0.39 1.19e-13 Mean platelet volume; CRC trans rs7826238 0.539 rs2945891 chr8:8155475 C/T cg16141378 chr3:129829833 LOC729375 -0.41 -6.04 -0.32 4.16e-9 Systolic blood pressure; CRC cis rs6952808 0.792 rs12537914 chr7:1948359 C/T cg00106254 chr7:1943704 MAD1L1 -0.52 -7.62 -0.39 2.82e-13 Bipolar disorder and schizophrenia; CRC cis rs7811142 1.000 rs112317829 chr7:100043173 A/G cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.02 14.75 0.63 3.76e-38 Platelet count; CRC cis rs7781266 0.793 rs4731968 chr7:133292697 A/G cg03336402 chr7:133662267 EXOC4 0.48 5.61 0.3 4.18e-8 Educational attainment (college completion); CRC cis rs3806843 1.000 rs10223116 chr5:140192643 C/T cg16607685 chr5:140181889 PCDHA2;PCDHA1;PCDHA3 -0.26 -5.9 -0.31 8.82e-9 Depressive symptoms (multi-trait analysis); CRC cis rs7727544 0.507 rs9791170 chr5:131569627 A/G cg20512303 chr5:131592959 PDLIM4 0.4 7.41 0.38 1.09e-12 Blood metabolite levels; CRC cis rs11690935 0.885 rs6752812 chr2:172851502 C/A cg13550731 chr2:172543902 DYNC1I2 -1.0 -15.56 -0.65 2.74e-41 Schizophrenia; CRC cis rs6933660 0.646 rs9397410 chr6:151770503 C/T cg17179660 chr6:151773299 C6orf211;RMND1 -0.44 -6.78 -0.35 5.66e-11 Menarche (age at onset); CRC cis rs11098499 0.615 rs28850368 chr4:120554313 G/A cg09307838 chr4:120376055 NA 0.61 9.3 0.46 2.01e-18 Corneal astigmatism; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg22476893 chr17:7210162 EIF5A 0.47 6.97 0.36 1.7e-11 Response to antipsychotic treatment; CRC cis rs9393777 0.557 rs36034627 chr6:27237363 G/T cg12292205 chr6:26970375 C6orf41 -0.8 -8.43 -0.42 1.07e-15 Intelligence (multi-trait analysis); CRC cis rs9616064 0.638 rs738244 chr22:46946127 C/T cg05621596 chr22:47072043 GRAMD4 -0.54 -8.08 -0.41 1.24e-14 Urate levels in obese individuals; CRC cis rs4713118 0.513 rs200971 chr6:27858904 C/T cg08798685 chr6:27730294 NA -0.41 -5.87 -0.31 1.06e-8 Parkinson's disease; CRC cis rs449789 0.524 rs1875819 chr6:159747743 A/G cg14500486 chr6:159655392 FNDC1 -0.49 -7.39 -0.38 1.21e-12 Pulse pressure; CRC cis rs6681460 0.576 rs1338194 chr1:66986476 T/A cg02459107 chr1:67143332 SGIP1 0.36 5.62 0.3 4.16e-8 Presence of antiphospholipid antibodies; CRC cis rs2645694 0.626 rs2645709 chr4:77824474 G/A cg18351406 chr4:77819688 ANKRD56 0.52 8.01 0.4 1.95e-14 Emphysema distribution in smoking; CRC cis rs7586879 0.616 rs6722587 chr2:25132192 C/A cg04586622 chr2:25135609 ADCY3 -0.54 -10.17 -0.49 2.64e-21 Body mass index; CRC cis rs7412746 0.611 rs2864873 chr1:150814174 A/G cg10589385 chr1:150898437 SETDB1 0.3 6.13 0.32 2.57e-9 Melanoma; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg21422400 chr1:1747243 GNB1 -0.45 -6.96 -0.36 1.81e-11 Liver disease severity in Alagille syndrome; CRC cis rs7586879 0.681 rs6545800 chr2:25118885 A/G cg22495460 chr2:25135724 ADCY3 0.87 16.91 0.68 1.34e-46 Body mass index; CRC trans rs9291683 0.507 rs6849273 chr4:10021595 C/T cg26043149 chr18:55253948 FECH 0.51 7.61 0.39 2.93e-13 Bone mineral density; CRC cis rs11212617 0.934 rs172896 chr11:108217049 T/G cg14761454 chr11:108092087 ATM;NPAT 0.43 6.47 0.34 3.64e-10 Response to metformin in type 2 diabetes (glycemic); CRC cis rs1129187 0.967 rs11752813 chr6:42928017 C/G cg05552183 chr6:42928497 GNMT 0.61 9.58 0.47 2.5e-19 Alzheimer's disease in APOE e4+ carriers; CRC cis rs7680126 0.644 rs62288518 chr4:10087464 T/C cg00071950 chr4:10020882 SLC2A9 -0.47 -6.34 -0.33 7.72e-10 Urate levels in lean individuals;Urate levels in overweight individuals;Urate levels in obese individuals; CRC cis rs11690935 0.959 rs7355594 chr2:172639448 G/T cg13550731 chr2:172543902 DYNC1I2 -1.09 -18.51 -0.71 6.56e-53 Schizophrenia; CRC cis rs1046896 0.503 rs12947062 chr17:80686370 A/G cg17346650 chr17:80929145 B3GNTL1 -0.36 -5.88 -0.31 9.87e-9 Glycated hemoglobin levels; CRC cis rs11098499 0.908 rs7695996 chr4:120322033 C/T cg24375607 chr4:120327624 NA 0.5 7.69 0.39 1.73e-13 Corneal astigmatism; CRC cis rs7412746 0.634 rs7521592 chr1:150821691 A/C cg15448220 chr1:150897856 SETDB1 0.55 7.75 0.39 1.13e-13 Melanoma; CRC cis rs274567 0.501 rs2631368 chr5:131705297 T/G cg04518342 chr5:131593106 PDLIM4 -0.44 -7.43 -0.38 9.63e-13 Blood metabolite levels; CRC cis rs801193 1.000 rs6975195 chr7:66124774 T/A cg11764359 chr7:65958608 NA -0.54 -8.3 -0.42 2.71e-15 Aortic root size; CRC cis rs7258465 0.931 rs1560119 chr19:18573675 A/G cg01065977 chr19:18549689 ISYNA1 -0.41 -6.43 -0.33 4.37e-10 Breast cancer; CRC cis rs7692995 1.000 rs1472852 chr4:17910236 C/A cg08925142 chr4:18023851 LCORL -0.52 -5.7 -0.3 2.73e-8 Height; CRC cis rs611744 0.506 rs13280454 chr8:109263240 A/G cg18478394 chr8:109455254 TTC35 0.39 6.07 0.32 3.47e-9 Dupuytren's disease; CRC cis rs10791323 0.569 rs1119851 chr11:133742842 T/C cg15485101 chr11:133734466 NA 0.43 8.11 0.41 9.96e-15 Childhood ear infection; CRC cis rs2404602 0.647 rs12910081 chr15:77022959 G/C cg23625390 chr15:77176239 SCAPER -0.86 -13.84 -0.61 1.22e-34 Blood metabolite levels; CRC cis rs540254 0.619 rs4656270 chr1:160779412 A/G cg20255094 chr1:160771763 LY9 0.49 6.42 0.33 4.64e-10 Blood protein levels; CRC cis rs6597981 0.675 rs4963120 chr11:825777 A/G cg21775979 chr11:780331 NA 0.39 5.73 0.3 2.23e-8 Breast cancer; CRC cis rs10782582 0.609 rs1251584 chr1:76424440 C/T cg03433033 chr1:76189801 ACADM 0.4 5.68 0.3 2.96e-8 Daytime sleep phenotypes; CRC cis rs4862750 0.872 rs7658314 chr4:187900356 T/C cg07414643 chr4:187882934 NA 0.39 6.95 0.36 1.94e-11 Lobe attachment (rater-scored or self-reported); CRC cis rs629535 0.814 rs506931 chr8:70068129 T/G cg26132723 chr8:70041827 NA 0.35 5.77 0.3 1.8e-8 Dupuytren's disease; CRC cis rs853679 0.607 rs34950484 chr6:28278688 G/A cg15845792 chr6:28175446 NA 0.85 5.82 0.31 1.36e-8 Depression; CRC cis rs6594499 1.000 rs1438673 chr5:110467499 C/T cg04022379 chr5:110408740 TSLP 0.43 6.54 0.34 2.41e-10 Allergic disease (asthma, hay fever or eczema); CRC cis rs1046896 1.000 rs1046875 chr17:80685426 A/G cg03160526 chr17:80928410 B3GNTL1 -0.49 -7.42 -0.38 9.96e-13 Glycated hemoglobin levels; CRC cis rs4713118 0.662 rs4713120 chr6:27721835 C/A cg25164649 chr6:28176230 NA 0.54 7.91 0.4 3.99e-14 Parkinson's disease; CRC cis rs2302190 0.769 rs7211294 chr17:56462783 G/A cg25885038 chr17:56607967 SEPT4 -0.45 -6.48 -0.34 3.32e-10 Vitamin D levels; CRC trans rs35094601 1.000 rs12621131 chr2:139225736 C/T cg25299176 chr17:1303341 YWHAE -0.47 -6.67 -0.35 1.1e-10 Schizophrenia; CRC trans rs3942852 0.910 rs11603850 chr11:48140900 G/A cg15704280 chr7:45808275 SEPT13 -0.58 -7.09 -0.36 8.03e-12 Acute lymphoblastic leukemia (childhood); CRC cis rs4819052 0.851 rs10470258 chr21:46658989 C/T cg19498844 chr21:46707878 POFUT2;LOC642852 0.77 10.99 0.52 3.97e-24 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs728616 0.717 rs17098169 chr10:81816134 C/T cg05935833 chr10:81318306 SFTPA2 0.53 6.28 0.33 1.09e-9 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs2976388 0.578 rs3736010 chr8:143817503 T/C cg22687807 chr8:143858763 LYNX1 -0.45 -6.95 -0.36 1.95e-11 Urinary tract infection frequency; CRC cis rs734999 0.545 rs4648356 chr1:2709164 C/A cg18854424 chr1:2615690 NA 0.42 7.84 0.4 6.46e-14 Ulcerative colitis; CRC cis rs11098499 0.604 rs2389887 chr4:120570644 T/C cg24375607 chr4:120327624 NA 0.51 7.64 0.39 2.47e-13 Corneal astigmatism; CRC cis rs1862618 0.853 rs832569 chr5:56154584 T/A cg24531977 chr5:56204891 C5orf35 -0.83 -10.99 -0.52 3.94e-24 Initial pursuit acceleration; CRC cis rs910316 1.000 rs175436 chr14:75608683 C/G cg08847533 chr14:75593920 NEK9 -0.91 -16.88 -0.68 1.77e-46 Height; CRC cis rs853679 0.517 rs3823180 chr6:28061744 G/A cg02631126 chr6:28058918 ZSCAN12L1 0.3 6.09 0.32 3.18e-9 Depression; CRC cis rs2120019 1.000 rs7167285 chr15:75368769 A/G cg09165964 chr15:75287851 SCAMP5 -0.79 -12.5 -0.57 1.36e-29 Blood trace element (Zn levels); CRC cis rs2228479 0.850 rs62054611 chr16:89817017 T/C cg19635926 chr16:89946313 TCF25 0.66 5.97 0.31 6.1e-9 Skin colour saturation; CRC cis rs753778 0.602 rs9792 chr8:142205237 C/T cg18755752 chr8:142205143 DENND3 0.66 11.73 0.54 8.54e-27 Reticulocyte fraction of red cells;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; CRC cis rs34779708 0.966 rs10827491 chr10:35427395 G/A cg03585969 chr10:35415529 CREM 0.55 7.41 0.38 1.08e-12 Inflammatory bowel disease;Crohn's disease; CRC cis rs4731207 0.591 rs9691875 chr7:124675705 A/T cg23710748 chr7:124431027 NA -0.39 -6.1 -0.32 2.98e-9 Cutaneous malignant melanoma; CRC cis rs10078 0.510 rs2278248 chr5:469570 G/T cg24955955 chr5:415729 AHRR 0.58 5.99 0.31 5.52e-9 Fat distribution (HIV); CRC cis rs3018066 0.692 rs6824682 chr4:107007919 G/A cg01869342 chr4:106983673 TBCK 0.44 6.47 0.34 3.56e-10 Cancer; CRC cis rs6502050 0.749 rs7209948 chr17:80086804 T/G cg02741985 chr17:80059408 CCDC57 -0.44 -7.15 -0.37 5.59e-12 Life satisfaction; CRC cis rs2408955 0.522 rs7139330 chr12:48483484 A/C cg24011408 chr12:48396354 COL2A1 -0.44 -6.47 -0.34 3.47e-10 Glycated hemoglobin levels; CRC cis rs3791406 0.929 rs3828202 chr2:240030122 A/G cg14550559 chr2:240039617 HDAC4 -0.52 -7.81 -0.4 7.89e-14 Skin aging (microtopography measurement); CRC cis rs1448094 0.512 rs7309500 chr12:86249647 C/T cg25456477 chr12:86230367 RASSF9 0.34 5.99 0.31 5.54e-9 Major depressive disorder; CRC trans rs2303319 0.504 rs56965753 chr2:162597251 A/G cg20024234 chr21:43431083 ZNF295 -0.66 -5.99 -0.31 5.57e-9 Cognitive function; CRC cis rs9467711 0.606 rs66823108 chr6:26377939 G/A cg16898833 chr6:26189333 HIST1H4D 0.8 6.76 0.35 6.48e-11 Autism spectrum disorder or schizophrenia; CRC cis rs8078723 0.668 rs4239225 chr17:38127112 G/A cg17467752 chr17:38218738 THRA 0.6 9.27 0.46 2.44e-18 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); CRC cis rs1552244 0.872 rs7646073 chr3:10097405 G/A cg10729496 chr3:10149963 C3orf24 0.5 6.78 0.35 5.69e-11 Alzheimer's disease; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg03041700 chr1:1407645 ATAD3B 0.46 6.56 0.34 2.13e-10 Response to antipsychotic treatment; CRC trans rs877282 0.853 rs7092652 chr10:756109 G/A cg22713356 chr15:30763199 NA 1.19 13.88 0.61 8.17e-35 Uric acid levels; CRC cis rs4356975 0.563 rs7657423 chr4:69955914 G/T cg25583503 chr4:69962676 UGT2B7 0.31 5.71 0.3 2.53e-8 Obesity-related traits; CRC cis rs16924133 0.793 rs12289960 chr11:33171742 C/G cg05567920 chr11:33183001 CSTF3 -0.75 -5.66 -0.3 3.31e-8 Anger; CRC cis rs10504073 0.584 rs4873092 chr8:49974053 T/C cg00325661 chr8:49890786 NA 0.58 10.44 0.5 3.1e-22 Blood metabolite ratios; CRC trans rs17685 0.753 rs10085567 chr7:75734206 A/C cg19862616 chr7:65841803 NCRNA00174 0.98 18.12 0.71 2.12e-51 Coffee consumption;Coffee consumption (cups per day); CRC cis rs7618915 0.547 rs62253703 chr3:52632357 T/C cg15147215 chr3:52552868 STAB1 -0.61 -10.13 -0.49 3.53e-21 Bipolar disorder; CRC cis rs11105298 0.786 rs10777186 chr12:89921277 G/A cg00757033 chr12:89920650 WDR51B 0.37 6.08 0.32 3.37e-9 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; CRC cis rs875971 0.825 rs1129531 chr7:65619104 C/T cg11764359 chr7:65958608 NA -0.62 -9.51 -0.46 4.32e-19 Aortic root size; CRC cis rs7937682 0.921 rs34584980 chr11:111441537 G/A cg09085632 chr11:111637200 PPP2R1B 0.97 15.3 0.64 2.66e-40 Primary sclerosing cholangitis; CRC cis rs12044355 0.927 rs11122321 chr1:231835610 A/C cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX 0.44 6.01 0.31 4.97e-9 Alzheimer's disease; CRC cis rs12620999 0.941 rs4408676 chr2:238085280 C/T cg23555395 chr2:238036564 NA -0.6 -9.75 -0.47 6.79e-20 Systemic lupus erythematosus; CRC trans rs7142881 0.508 rs8013530 chr14:32142930 C/T cg07244268 chr3:164924675 NA -0.44 -6.05 -0.32 4.05e-9 Response to iloperidone treatment (QT prolongation); CRC cis rs524281 0.773 rs79770412 chr11:66045344 G/C cg14036092 chr11:66035641 RAB1B -0.54 -6.0 -0.31 5.25e-9 Electroencephalogram traits; CRC trans rs1005277 0.579 rs2474588 chr10:38420870 A/G cg23533926 chr12:111358616 MYL2 -0.52 -7.91 -0.4 3.95e-14 Extrinsic epigenetic age acceleration; CRC cis rs7249142 0.527 rs12975096 chr19:19279409 G/T cg12558012 chr19:19281197 LOC729991-MEF2B;MEF2B 0.55 8.6 0.43 3.24e-16 IgG glycosylation; CRC cis rs3809863 0.646 rs9899121 chr17:45395144 C/T cg08085267 chr17:45401833 C17orf57 -0.8 -13.06 -0.58 1.13e-31 Glaucoma (primary open-angle); CRC cis rs4253772 0.637 rs9627350 chr22:46663017 A/G cg03482458 chr22:46692211 CN5H6.4;GTSE1 0.56 7.18 0.37 4.77e-12 LDL cholesterol;Cholesterol, total; CRC cis rs1448094 0.556 rs61930632 chr12:86168937 A/C cg25456477 chr12:86230367 RASSF9 0.4 6.73 0.35 7.75e-11 Major depressive disorder; CRC cis rs10504229 0.593 rs80174614 chr8:58024631 G/A cg02290350 chr8:58132656 NA -0.46 -5.84 -0.31 1.24e-8 Developmental language disorder (linguistic errors); CRC cis rs728616 0.681 rs55838345 chr10:82085120 G/C cg11900509 chr10:81946545 ANXA11 -0.54 -6.11 -0.32 2.86e-9 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs2032447 0.670 rs198845 chr6:26107790 A/C cg18357526 chr6:26021779 HIST1H4A 0.69 10.34 0.5 7e-22 Intelligence (multi-trait analysis); CRC cis rs939584 1.000 rs7558910 chr2:645122 C/G cg03610516 chr2:642275 NA 0.42 5.88 0.31 9.94e-9 Body mass index; CRC cis rs637571 0.522 rs28578718 chr11:65748400 C/A cg26695010 chr11:65641043 EFEMP2 -0.4 -6.07 -0.32 3.48e-9 Eosinophil percentage of white cells; CRC cis rs11785400 1.000 rs10099892 chr8:143734608 C/T cg10596483 chr8:143751796 JRK 0.49 6.99 0.36 1.54e-11 Schizophrenia; CRC trans rs7800418 0.723 rs4461797 chr7:26588044 C/T cg14387656 chr2:233470847 EFHD1 0.45 6.17 0.32 2.05e-9 Cognitive function; CRC cis rs7618915 0.570 rs11714088 chr3:52758942 A/C cg10802521 chr3:52805072 NEK4 -0.59 -8.98 -0.44 2.07e-17 Bipolar disorder; CRC cis rs8077889 0.917 rs9894873 chr17:41911832 A/G cg26893861 chr17:41843967 DUSP3 0.87 11.64 0.54 1.87e-26 Triglycerides; CRC cis rs7586879 0.681 rs6705446 chr2:25118608 T/C cg04586622 chr2:25135609 ADCY3 -0.55 -10.2 -0.49 2.06e-21 Body mass index; CRC cis rs892085 0.654 rs8106691 chr19:10889469 C/A cg17710535 chr19:10819994 QTRT1 0.38 5.7 0.3 2.71e-8 Psoriasis vulgaris;Psoriasis; CRC cis rs7737355 0.504 rs31256 chr5:130828749 T/C cg06307176 chr5:131281290 NA 0.41 6.02 0.31 4.78e-9 Life satisfaction; CRC cis rs116095464 0.558 rs56127718 chr5:270273 G/T cg22857025 chr5:266934 NA -1.24 -16.72 -0.68 7.21e-46 Breast cancer; CRC cis rs853679 0.517 rs56310871 chr6:28044482 A/G cg23161317 chr6:28129485 ZNF389 0.52 6.4 0.33 5.21e-10 Depression; CRC cis rs4665809 1.000 rs4665308 chr2:26330514 C/A cg26119090 chr2:26468346 HADHA;HADHB -0.61 -7.88 -0.4 4.97e-14 Gut microbiome composition (summer); CRC cis rs6938 0.534 rs1127796 chr15:75193004 C/T cg17294928 chr15:75287854 SCAMP5 -0.58 -9.16 -0.45 5.58e-18 Breast cancer; CRC cis rs1865760 0.622 rs10946807 chr6:26079638 T/C cg16482183 chr6:26056742 HIST1H1C 0.64 8.66 0.43 2.15e-16 Height; CRC cis rs2415984 0.562 rs1494092 chr14:46970304 T/C cg14871534 chr14:47121158 RPL10L 0.41 5.73 0.3 2.29e-8 Number of children ever born; CRC trans rs7615952 0.546 rs2979338 chr3:125343126 G/T cg07211511 chr3:129823064 LOC729375 -0.62 -7.25 -0.37 3.03e-12 Blood pressure (smoking interaction); CRC cis rs9818758 0.607 rs9837237 chr3:49215583 G/T cg00383909 chr3:49044727 WDR6 1.08 10.7 0.51 4.09e-23 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; CRC cis rs9487051 0.807 rs7748641 chr6:109592381 C/T cg01475377 chr6:109611718 NA -0.47 -8.94 -0.44 2.86e-17 Reticulocyte fraction of red cells; CRC cis rs6460942 0.731 rs75994414 chr7:12307992 C/A cg06484146 chr7:12443880 VWDE -0.71 -7.26 -0.37 2.84e-12 Coronary artery disease; CRC cis rs10504229 0.679 rs17800895 chr8:58050085 A/G cg20607798 chr8:58055168 NA 0.52 6.14 0.32 2.44e-9 Developmental language disorder (linguistic errors); CRC cis rs2398893 0.960 rs7849645 chr9:96744232 A/T cg14459158 chr9:96720562 NA 0.47 7.43 0.38 9.16e-13 Waist-hip ratio;Waist-to-hip ratio adjusted for body mass index; CRC cis rs514406 0.607 rs1930305 chr1:53195481 G/T cg25767906 chr1:53392781 SCP2 0.43 6.72 0.35 7.95e-11 Monocyte count; CRC cis rs1448094 0.511 rs56291271 chr12:86162287 G/A cg02569458 chr12:86230093 RASSF9 0.47 7.78 0.39 9.77e-14 Major depressive disorder; CRC cis rs1799949 0.965 rs33925201 chr17:41280682 A/G cg23758822 chr17:41437982 NA 0.79 13.38 0.59 6.66e-33 Menopause (age at onset); CRC cis rs4713118 0.621 rs9295755 chr6:28033174 C/T cg06470822 chr6:28175283 NA -0.9 -12.14 -0.56 2.77e-28 Parkinson's disease; CRC cis rs17433780 0.666 rs2624 chr1:89518623 C/T cg09516651 chr1:89888402 LOC400759 -0.47 -7.48 -0.38 6.68e-13 Carotid intima media thickness; CRC cis rs847649 0.804 rs4729866 chr7:102685561 A/C cg18108683 chr7:102477205 FBXL13 0.54 8.86 0.44 5.18e-17 Morning vs. evening chronotype; CRC cis rs853679 0.517 rs7755442 chr6:28039015 T/C cg06470822 chr6:28175283 NA 0.98 13.08 0.59 8.77e-32 Depression; CRC cis rs6445967 1.000 rs11712758 chr3:58306579 T/C cg23715586 chr3:58305044 RPP14 0.34 5.71 0.3 2.55e-8 Platelet count; CRC cis rs13191362 0.938 rs13208970 chr6:163006368 G/T cg06582575 chr6:163149167 PACRG;PARK2 0.73 10.55 0.5 1.3e-22 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs10911251 0.546 rs12034436 chr1:183114797 A/G ch.1.3577855R chr1:183094577 LAMC1 0.83 14.52 0.63 2.87e-37 Colorectal cancer; CRC cis rs9308731 0.644 rs1837366 chr2:111874629 C/T cg04202892 chr2:111875749 ACOXL 0.46 7.59 0.39 3.23e-13 Chronic lymphocytic leukemia; CRC cis rs1448094 0.512 rs7309500 chr12:86249647 C/T cg02569458 chr12:86230093 RASSF9 0.43 7.41 0.38 1.06e-12 Major depressive disorder; CRC trans rs10982213 0.830 rs2274163 chr9:117188714 C/T cg14479329 chr6:167370587 RNASET2 0.4 6.06 0.32 3.62e-9 Interleukin-6 levels; CRC cis rs9611565 0.546 rs739134 chr22:42089623 T/C cg06634786 chr22:41940651 POLR3H 0.54 6.4 0.33 5.49e-10 Vitiligo; CRC cis rs7618915 0.547 rs2164884 chr3:52629633 C/T cg05573699 chr3:52720067 GNL3;PBRM1 -0.46 -6.62 -0.34 1.44e-10 Bipolar disorder; CRC cis rs9322193 0.961 rs9285521 chr6:149906712 T/G cg07701084 chr6:150067640 NUP43 0.57 8.23 0.41 4.51e-15 Lung cancer; CRC cis rs7849270 1.000 rs10819466 chr9:131881492 G/C cg13538475 chr9:131942899 NA -0.29 -5.89 -0.31 9.75e-9 Blood metabolite ratios; CRC cis rs12887734 0.566 rs8548 chr14:104199580 A/C cg08213375 chr14:104286397 PPP1R13B 0.47 7.42 0.38 1.01e-12 Schizophrenia;Autism spectrum disorder or schizophrenia; CRC cis rs1862618 0.853 rs861283 chr5:56184610 C/T cg20203395 chr5:56204925 C5orf35 -0.72 -8.29 -0.42 2.99e-15 Initial pursuit acceleration; CRC cis rs589448 0.902 rs315113 chr12:69786543 G/T cg20891283 chr12:69753455 YEATS4 -0.97 -20.58 -0.75 4.69e-61 Cerebrospinal fluid biomarker levels; CRC trans rs1455244 0.700 rs7229302 chr18:11508904 G/T cg06258179 chr7:92463261 CDK6 0.38 6.08 0.32 3.42e-9 Schizophrenia; CRC cis rs561341 0.609 rs9906443 chr17:30185565 C/T cg13647721 chr17:30228624 UTP6 -0.63 -7.17 -0.37 5.02e-12 Hip circumference adjusted for BMI; CRC cis rs4731207 0.698 rs4377885 chr7:124533680 A/G cg23710748 chr7:124431027 NA 0.37 5.9 0.31 9.15e-9 Cutaneous malignant melanoma; CRC cis rs10504229 0.769 rs17215649 chr8:58152791 A/G cg22535103 chr8:58192502 C8orf71 -0.68 -8.37 -0.42 1.72e-15 Developmental language disorder (linguistic errors); CRC cis rs4713118 0.955 rs9468201 chr6:27687035 C/T cg12273811 chr6:28175739 NA 0.5 6.91 0.36 2.57e-11 Parkinson's disease; CRC cis rs875971 0.895 rs10755833 chr7:65913917 A/G cg12463550 chr7:65579703 CRCP 0.48 6.78 0.35 5.54e-11 Aortic root size; CRC cis rs11997175 0.819 rs6415400 chr8:33783714 C/T ch.8.33884649F chr8:33765107 NA 0.46 7.04 0.36 1.13e-11 Body mass index; CRC cis rs853679 0.628 rs9368560 chr6:28159960 T/C cg12172441 chr6:28176163 NA 0.67 8.63 0.43 2.64e-16 Depression; CRC cis rs2797160 1.000 rs1777194 chr6:126004883 G/A cg05901451 chr6:126070800 HEY2 -0.41 -6.21 -0.32 1.61e-9 Endometrial cancer; CRC cis rs1670533 1.000 rs652063 chr4:1084137 T/C cg27284194 chr4:1044797 NA 0.5 6.33 0.33 7.9e-10 Recombination rate (females); CRC cis rs6062302 0.522 rs2282157 chr20:62227180 C/G cg06363034 chr20:62225388 GMEB2 -0.45 -6.88 -0.35 2.94e-11 Glioblastoma; CRC cis rs9921222 1.000 rs9921222 chr16:375782 A/G cg08923669 chr16:420230 MRPL28 0.49 7.05 0.36 1.05e-11 Bone mineral density (spine);Bone mineral density; CRC cis rs2227564 0.700 rs12413039 chr10:75524759 C/G cg16540259 chr10:75572220 NDST2 -0.43 -6.02 -0.31 4.72e-9 Crohn's disease;Inflammatory bowel disease; CRC cis rs10751667 1.000 rs6597965 chr11:964476 A/G cg01483505 chr11:975446 AP2A2 0.4 6.14 0.32 2.31e-9 Alzheimer's disease (late onset); CRC cis rs2276314 0.748 rs4799839 chr18:33597531 T/C cg19628046 chr18:33552617 C18orf21 0.55 7.23 0.37 3.41e-12 Endometriosis;Drug-induced torsades de pointes; CRC trans rs8002861 0.781 rs3816311 chr13:44453783 G/A cg17145862 chr1:211918768 LPGAT1 0.76 15.09 0.64 1.83e-39 Leprosy; CRC cis rs7584330 0.617 rs10202195 chr2:238352128 A/G cg14458575 chr2:238380390 NA 0.67 11.49 0.54 6.22e-26 Prostate cancer; CRC cis rs9303280 0.773 rs11078925 chr17:38025208 T/C cg17344932 chr17:38183730 MED24;SNORD124 0.37 5.93 0.31 7.68e-9 Self-reported allergy; CRC cis rs826838 0.967 rs1684414 chr12:39129553 A/G cg13010199 chr12:38710504 ALG10B -0.41 -5.84 -0.31 1.27e-8 Heart rate; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg05385059 chr20:60718641 SS18L1;PSMA7 0.43 6.06 0.32 3.75e-9 Anxiety disorder; CRC cis rs2688482 0.512 rs3103953 chr3:195520597 G/A cg18918831 chr3:195489782 MUC4 -0.67 -7.59 -0.39 3.25e-13 Lung disease severity in cystic fibrosis; CRC cis rs9287719 0.649 rs10803724 chr2:10732323 C/T cg00105475 chr2:10696890 NA 0.44 7.0 0.36 1.43e-11 Prostate cancer; CRC cis rs9549260 0.755 rs2701863 chr13:41170140 C/T cg21288729 chr13:41239152 FOXO1 0.39 5.9 0.31 8.93e-9 Red blood cell count; CRC cis rs2982552 0.844 rs2982560 chr6:152055606 A/T cg22157087 chr6:152012887 ESR1 0.38 5.82 0.31 1.38e-8 Bone properties (heel); CRC cis rs6541297 1.000 rs7543050 chr1:230278291 C/G cg20703242 chr1:230279135 GALNT2 0.53 8.06 0.41 1.4e-14 Coronary artery disease; CRC cis rs3617 0.573 rs12492391 chr3:52912296 C/A cg07507251 chr3:52567010 NT5DC2 0.39 5.84 0.31 1.26e-8 Red blood cell count;Autism spectrum disorder or schizophrenia; CRC cis rs6582630 0.555 rs11182429 chr12:38526679 A/C cg26384229 chr12:38710491 ALG10B 0.69 9.87 0.48 2.74e-20 Drug-induced liver injury (flucloxacillin); CRC trans rs1814175 0.817 rs10769613 chr11:49769692 G/A cg21153622 chr11:89784906 NA -0.39 -6.2 -0.32 1.7e-9 Height; CRC cis rs1801251 0.778 rs2675957 chr2:233754364 C/T cg25237894 chr2:233734115 C2orf82 -0.63 -10.88 -0.51 9.62e-24 Coronary artery disease; CRC cis rs2425143 1.000 rs56904633 chr20:34400757 T/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.47 -5.64 -0.3 3.73e-8 Blood protein levels; CRC cis rs6502050 0.805 rs4789740 chr17:80119202 T/C cg25804541 chr17:80189381 SLC16A3 -0.31 -5.96 -0.31 6.46e-9 Life satisfaction; CRC cis rs9322193 0.923 rs17745062 chr6:150042215 T/A cg07701084 chr6:150067640 NUP43 0.56 8.29 0.42 2.92e-15 Lung cancer; CRC cis rs11191205 0.644 rs11191069 chr10:103388129 A/C cg15320455 chr10:103880129 LDB1 -0.58 -6.36 -0.33 6.77e-10 Intelligence (multi-trait analysis); CRC cis rs763121 0.853 rs5757234 chr22:39072686 C/T cg06022373 chr22:39101656 GTPBP1 0.82 13.7 0.6 4.13e-34 Menopause (age at onset); CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg11176924 chr14:24740855 RABGGTA 0.46 6.25 0.33 1.25e-9 Anxiety disorder; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg27005246 chr16:31044731 STX4 0.43 5.97 0.31 6.18e-9 Response to antipsychotic treatment; CRC cis rs2565722 0.622 rs2489947 chr6:161301113 A/G cg03159191 chr6:161285451 NA -0.46 -6.28 -0.33 1.07e-9 Blood protein levels; CRC cis rs2252521 0.524 rs2214973 chr7:29059891 A/G cg11728747 chr7:29037910 CPVL -0.48 -7.01 -0.36 1.37e-11 Cognitive performance; CRC cis rs910316 1.000 rs175425 chr14:75626131 T/C cg08847533 chr14:75593920 NEK9 -0.93 -16.96 -0.68 8.53e-47 Height; CRC cis rs2108622 0.711 rs113059233 chr19:15977368 G/A cg13772218 chr19:15982569 NA 0.46 6.43 0.33 4.44e-10 Circulating phylloquinone levels;Vitamin E levels;Acenocoumarol maintenance dosage;Response to Vitamin E supplementation;Metabolite levels;Warfarin maintenance dose; CRC cis rs425277 1.000 rs262665 chr1:2083173 A/G cg24578937 chr1:2090814 PRKCZ 0.66 11.73 0.54 8.84e-27 Height; CRC cis rs62064224 0.606 rs61390192 chr17:30837447 C/T cg25809561 chr17:30822961 MYO1D 0.71 12.23 0.56 1.29e-28 Schizophrenia; CRC cis rs1465370 0.682 rs2239604 chr7:130021331 C/T cg03229158 chr7:130009420 NA 0.43 6.19 0.32 1.8e-9 Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction);Waist circumference adjusted for BMI in active individuals;Waist circumference adjusted for body mass index; CRC cis rs4819052 0.851 rs58644915 chr21:46669912 T/C cg19498844 chr21:46707878 POFUT2;LOC642852 0.75 10.66 0.51 5.52e-23 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs35306767 0.903 rs17159970 chr10:935601 T/C cg26597838 chr10:835615 NA 0.98 11.72 0.54 9.41e-27 Eosinophil percentage of granulocytes; CRC cis rs6951245 1.000 rs80094748 chr7:1103958 G/A cg24642844 chr7:1081250 C7orf50 -0.76 -9.16 -0.45 5.7e-18 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs1976403 0.659 rs10799701 chr1:21820990 A/G cg00786952 chr1:21763130 NA 0.52 9.18 0.45 5.09e-18 Liver enzyme levels (alkaline phosphatase); CRC cis rs798554 0.757 rs1182179 chr7:2873648 A/G cg04166393 chr7:2884313 GNA12 0.51 6.78 0.35 5.51e-11 Height; CRC cis rs62458065 0.850 rs28677012 chr7:32469811 C/A cg20159608 chr7:32802032 NA -0.56 -6.75 -0.35 6.67e-11 Metabolite levels (HVA/MHPG ratio); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg22802068 chr17:900285 TIMM22 0.36 6.08 0.32 3.3e-9 Liver disease severity in Alagille syndrome; CRC cis rs11059919 1 rs11059919 chr12:129289190 G/A cg04043695 chr12:129287642 SLC15A4 0.38 5.68 0.3 3e-8 Systemic lupus erythematosus; CRC cis rs67311347 1.000 rs7631893 chr3:40440869 C/T cg24209194 chr3:40518798 ZNF619 0.43 6.65 0.34 1.25e-10 Renal cell carcinoma; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg04436474 chr3:49977685 RBM6 0.53 7.33 0.37 1.85e-12 Response to antipsychotic treatment; CRC cis rs7633770 0.841 rs11709020 chr3:46680063 A/G cg11219411 chr3:46661640 NA -0.7 -12.07 -0.55 5.14e-28 Coronary artery disease; CRC trans rs875971 0.660 rs2191268 chr7:66110224 C/T cg14430738 chr6:26596151 ABT1 -0.38 -6.25 -0.33 1.3e-9 Aortic root size; CRC cis rs6582630 0.519 rs2387812 chr12:38381480 A/G cg13010199 chr12:38710504 ALG10B 0.47 6.43 0.33 4.6e-10 Drug-induced liver injury (flucloxacillin); CRC cis rs8070740 0.898 rs4442872 chr17:5324236 C/T cg25236894 chr17:5323110 RPAIN;NUP88 0.48 7.46 0.38 7.92e-13 Menopause (age at onset); CRC cis rs1816752 0.870 rs7981337 chr13:25015053 A/C cg02811702 chr13:24901961 NA 0.48 6.63 0.34 1.4e-10 Obesity-related traits; CRC cis rs11212617 0.967 rs371406 chr11:108221482 A/G cg14761454 chr11:108092087 ATM;NPAT 0.39 5.61 0.3 4.3e-8 Response to metformin in type 2 diabetes (glycemic); CRC cis rs68170813 0.559 rs5002976 chr7:107050620 C/G cg02696742 chr7:106810147 HBP1 -0.57 -5.95 -0.31 6.9e-9 Coronary artery disease; CRC cis rs8014204 0.762 rs10138360 chr14:75293386 A/G cg03030879 chr14:75389066 RPS6KL1 0.41 6.38 0.33 6.08e-10 Caffeine consumption; CRC cis rs13108904 0.517 rs13134568 chr4:1334289 G/A cg24560729 chr4:1342394 KIAA1530 0.38 6.13 0.32 2.53e-9 Obesity-related traits; CRC cis rs546131 0.928 rs552171 chr11:34830709 G/T cg11058730 chr11:34937778 PDHX;APIP 0.44 6.35 0.33 6.97e-10 Lung disease severity in cystic fibrosis; CRC cis rs9527 0.590 rs7088200 chr10:104793235 G/A cg15744005 chr10:104629667 AS3MT -0.31 -6.21 -0.32 1.59e-9 Arsenic metabolism; CRC cis rs1018836 0.923 rs756569 chr8:91610957 G/A cg16814680 chr8:91681699 NA -0.75 -11.7 -0.54 1.09e-26 Ejection fraction in Tripanosoma cruzi seropositivity; CRC cis rs3008870 0.959 rs56707923 chr1:67388016 T/C cg08660285 chr1:67390436 MIER1;WDR78 1.04 16.07 0.66 2.57e-43 Lymphocyte percentage of white cells; CRC cis rs2032447 0.714 rs175319 chr6:25956172 A/G cg12310025 chr6:25882481 NA -0.63 -9.03 -0.45 1.48e-17 Intelligence (multi-trait analysis); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg24496317 chr7:24613120 MPP6 0.46 6.79 0.35 5.27e-11 Intelligence (multi-trait analysis); CRC trans rs35110281 0.807 rs9984002 chr21:45061501 T/C cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.54 9.19 0.45 4.45e-18 Mean corpuscular volume; CRC cis rs801193 1.000 rs11773829 chr7:66141074 G/A cg00343986 chr7:65444356 GUSB -0.5 -7.44 -0.38 8.98e-13 Aortic root size; CRC cis rs938554 0.784 rs7682751 chr4:9976294 A/G cg00071950 chr4:10020882 SLC2A9 0.47 6.65 0.34 1.21e-10 Blood metabolite levels; CRC cis rs10911232 0.507 rs6660111 chr1:183014289 G/A ch.1.3577855R chr1:183094577 LAMC1 0.81 13.48 0.6 2.83e-33 Hypertriglyceridemia; CRC trans rs10982213 0.830 rs2274163 chr9:117188714 C/T cg08125682 chr16:11038455 CLEC16A 0.4 6.46 0.34 3.81e-10 Interleukin-6 levels; CRC cis rs9788721 0.836 rs17484235 chr15:78761414 C/G cg18825076 chr15:78729989 IREB2 -0.48 -7.07 -0.36 9.27e-12 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio;Emphysema imaging phenotypes;Emphysema distribution in smoking;Local histogram emphysema pattern;Post bronchodilator FEV1/FVC ratio in COPD; CRC cis rs904251 0.714 rs2776910 chr6:37436284 A/G cg25019722 chr6:37503610 NA -0.4 -6.02 -0.32 4.53e-9 Cognitive performance; CRC cis rs4664293 0.647 rs4665099 chr2:160495538 G/A cg08347373 chr2:160653686 CD302 0.39 6.68 0.35 1.03e-10 Monocyte percentage of white cells; CRC cis rs365302 1.000 rs485626 chr6:159651279 A/G cg14500486 chr6:159655392 FNDC1 0.44 6.78 0.35 5.7e-11 Coronary heart disease; CRC cis rs6951245 1.000 rs76129108 chr7:1089159 G/A cg20603222 chr7:1096387 C7orf50;GPR146 -0.73 -8.49 -0.42 7.07e-16 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs9322193 0.884 rs9688858 chr6:149959047 C/A cg13206674 chr6:150067644 NUP43 0.58 8.43 0.42 1.11e-15 Lung cancer; CRC cis rs7584330 0.638 rs13429533 chr2:238448712 A/G cg14458575 chr2:238380390 NA 0.43 7.61 0.39 2.95e-13 Prostate cancer; CRC cis rs9287719 0.967 rs2884233 chr2:10745303 G/A cg00105475 chr2:10696890 NA 0.45 7.21 0.37 3.91e-12 Prostate cancer; CRC cis rs6951245 1.000 rs77760339 chr7:1083927 G/T cg04025307 chr7:1156635 C7orf50 0.64 6.76 0.35 6.29e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs10504229 0.953 rs78089850 chr8:58171557 A/G cg05313129 chr8:58192883 C8orf71 -0.47 -6.86 -0.35 3.35e-11 Developmental language disorder (linguistic errors); CRC cis rs1799949 0.896 rs8176098 chr17:41268206 A/C cg23758822 chr17:41437982 NA 0.79 13.35 0.59 9.09e-33 Menopause (age at onset); CRC cis rs9322193 0.961 rs9767713 chr6:149909377 T/G cg13206674 chr6:150067644 NUP43 0.65 9.25 0.45 2.82e-18 Lung cancer; CRC cis rs7119 0.931 rs11630540 chr15:77833625 G/A cg10437265 chr15:77819839 NA 0.58 10.38 0.5 5.07e-22 Type 2 diabetes; CRC cis rs2479724 0.870 rs6913232 chr6:41915143 C/T cg17623882 chr6:41773611 USP49 0.51 8.21 0.41 4.97e-15 Menarche (age at onset); CRC cis rs7998202 0.614 rs282573 chr13:113362105 G/A cg01692110 chr13:113365389 ATP11A -0.5 -5.98 -0.31 5.89e-9 Glycated hemoglobin levels; CRC cis rs10504229 1.000 rs949848 chr8:58169125 A/G cg02725872 chr8:58115012 NA -0.38 -6.61 -0.34 1.58e-10 Developmental language disorder (linguistic errors); CRC cis rs11212617 0.967 rs227062 chr11:108205383 G/A cg01991180 chr11:108092276 ATM;NPAT 0.42 6.26 0.33 1.2e-9 Response to metformin in type 2 diabetes (glycemic); CRC cis rs9517313 0.707 rs9517298 chr13:99095003 C/T cg07423050 chr13:99094983 FARP1 -0.66 -10.25 -0.49 1.46e-21 Neuroticism; CRC cis rs9837602 0.529 rs793494 chr3:99508768 T/C cg08350549 chr3:99591722 C3orf26;FILIP1L;MIR548G -0.38 -5.9 -0.31 8.95e-9 Breast cancer; CRC cis rs6586163 0.872 rs1926200 chr10:90746533 G/A cg03111039 chr10:90751583 FAS;ACTA2 -0.5 -7.21 -0.37 3.77e-12 Chronic lymphocytic leukemia; CRC cis rs2976388 0.556 rs4736321 chr8:143822194 C/T cg10596483 chr8:143751796 JRK -0.49 -6.69 -0.35 9.65e-11 Urinary tract infection frequency; CRC cis rs57561814 0.510 rs1800796 chr7:22766246 G/C cg26061582 chr7:22766209 IL6 0.95 7.14 0.37 6.13e-12 Tonsillectomy; CRC cis rs1552244 0.554 rs7638846 chr3:10048601 A/G cg00166722 chr3:10149974 C3orf24 0.46 6.7 0.35 9.05e-11 Alzheimer's disease; CRC cis rs7727544 0.545 rs10074490 chr5:131340032 C/T cg12564285 chr5:131593104 PDLIM4 0.32 5.71 0.3 2.49e-8 Blood metabolite levels; CRC cis rs9372498 0.536 rs9489409 chr6:118802721 A/G cg22561889 chr6:118971681 C6orf204 0.51 6.47 0.34 3.45e-10 Diastolic blood pressure; CRC cis rs2745967 0.791 rs2724379 chr1:208076856 A/C cg09788693 chr1:208063733 CD34 0.41 6.37 0.33 6.36e-10 Resting heart rate; CRC cis rs11098499 0.863 rs3822190 chr4:120428098 G/A cg24375607 chr4:120327624 NA 0.46 6.98 0.36 1.63e-11 Corneal astigmatism; CRC cis rs9534288 0.797 rs1319712 chr13:46591707 T/C cg15192986 chr13:46630673 CPB2 -0.66 -9.67 -0.47 1.23e-19 Blood protein levels; CRC cis rs4319547 0.656 rs7294559 chr12:122837564 C/A cg23029597 chr12:123009494 RSRC2 -0.52 -6.3 -0.33 9.27e-10 Body mass index; CRC cis rs8060686 0.563 rs118005841 chr16:68157562 A/T cg08314208 chr16:67682810 RLTPR -0.59 -6.37 -0.33 6.28e-10 HDL cholesterol;Metabolic syndrome; CRC cis rs8014204 0.748 rs12889277 chr14:75229376 A/T cg03030879 chr14:75389066 RPS6KL1 -0.49 -7.91 -0.4 4.02e-14 Caffeine consumption; CRC cis rs9399135 0.967 rs1041481 chr6:135335063 G/A cg22676075 chr6:135203613 NA 0.41 6.35 0.33 7.16e-10 Red blood cell count; CRC cis rs8005677 0.770 rs56180741 chr14:23377246 T/C cg25600027 chr14:23388339 RBM23 -0.46 -6.99 -0.36 1.54e-11 Cognitive ability (multi-trait analysis); CRC cis rs10504229 0.683 rs11786043 chr8:58133174 T/C cg21724239 chr8:58056113 NA 0.49 6.81 0.35 4.75e-11 Developmental language disorder (linguistic errors); CRC cis rs13256369 1.000 rs10098234 chr8:8576692 G/A cg17143192 chr8:8559678 CLDN23 0.45 5.76 0.3 1.89e-8 Obesity-related traits; CRC cis rs57221529 0.766 rs72703042 chr5:579269 C/T cg09021430 chr5:549028 NA -0.72 -7.86 -0.4 5.63e-14 Lung disease severity in cystic fibrosis; CRC trans rs11098499 0.821 rs28665282 chr4:120384186 C/T cg25214090 chr10:38739885 LOC399744 0.66 10.55 0.5 1.36e-22 Corneal astigmatism; CRC cis rs8170 1.000 rs10416654 chr19:17385176 T/C cg04749549 chr19:17459798 NA -0.43 -5.88 -0.31 1.01e-8 Breast cancer (estrogen-receptor negative);Breast Cancer in BRCA1 mutation carriers;Ovarian cancer;Breast cancer;Epithelial ovarian cancer; CRC trans rs2797160 0.714 rs1777220 chr6:126022602 G/T cg05039488 chr6:79577232 IRAK1BP1 0.58 8.81 0.44 7.22e-17 Endometrial cancer; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg07830110 chr22:38794284 LOC400927 0.51 7.65 0.39 2.24e-13 Intelligence (multi-trait analysis); CRC cis rs910316 0.737 rs175065 chr14:75494983 T/C cg03030879 chr14:75389066 RPS6KL1 0.43 6.63 0.34 1.39e-10 Height; CRC cis rs533581 0.866 rs865102 chr16:88969969 A/G cg05579598 chr16:88989069 CBFA2T3 0.33 6.84 0.35 3.83e-11 Social autistic-like traits; CRC cis rs7412746 0.588 rs10305664 chr1:150839686 A/C cg10589385 chr1:150898437 SETDB1 0.32 6.53 0.34 2.52e-10 Melanoma; CRC cis rs853679 0.517 rs16893666 chr6:28054707 C/T cg02683197 chr6:28174875 NA -0.82 -10.15 -0.49 3.13e-21 Depression; CRC cis rs9322193 0.886 rs4039600 chr6:149897455 A/G cg13206674 chr6:150067644 NUP43 0.56 8.0 0.4 2.14e-14 Lung cancer; CRC cis rs4727027 0.754 rs917124 chr7:148851213 C/T cg23583168 chr7:148888333 NA -0.78 -11.58 -0.54 2.98e-26 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC cis rs9291683 0.692 rs1558489 chr4:10325489 T/A cg11266682 chr4:10021025 SLC2A9 -0.41 -7.89 -0.4 4.46e-14 Bone mineral density; CRC cis rs7677751 0.806 rs4864858 chr4:55089953 T/A cg00691999 chr4:55094011 PDGFRA 0.44 6.34 0.33 7.43e-10 Corneal astigmatism; CRC cis rs873946 0.648 rs3750578 chr10:134563366 A/G cg06453172 chr10:134556979 INPP5A -0.68 -8.16 -0.41 7.16e-15 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CRC cis rs2075371 0.796 rs10954440 chr7:134005657 C/T cg02659138 chr7:134003124 SLC35B4 0.39 6.68 0.35 1.04e-10 Mean platelet volume; CRC cis rs6500602 0.702 rs2270366 chr16:4558615 A/G cg14951292 chr16:4525986 HMOX2;NMRAL1 -0.57 -8.58 -0.43 3.74e-16 Schizophrenia; CRC cis rs2425143 1.000 rs1890470 chr20:34357008 C/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.48 -6.17 -0.32 1.97e-9 Blood protein levels; CRC trans rs7942260 1.000 rs56352228 chr11:94346099 A/G cg10632000 chr19:42806201 PRR19;PAFAH1B3 -0.55 -6.04 -0.32 4.19e-9 Colorectal cancer; CRC cis rs2976388 0.647 rs2164307 chr8:143788831 A/T cg22687807 chr8:143858763 LYNX1 0.49 8.92 0.44 3.32e-17 Urinary tract infection frequency; CRC cis rs9443189 0.570 rs7770824 chr6:76408189 G/A cg01950844 chr6:76311363 SENP6 0.74 9.84 0.48 3.35e-20 Prostate cancer; CRC cis rs12497850 0.931 rs9867373 chr3:48960938 A/T cg20833759 chr3:49053208 WDR6;DALRD3 0.53 9.22 0.45 3.67e-18 Parkinson's disease; CRC cis rs6952808 0.723 rs4721264 chr7:2012997 G/A cg02951883 chr7:2050386 MAD1L1 -0.78 -12.69 -0.57 2.72e-30 Bipolar disorder and schizophrenia; CRC cis rs8016982 0.674 rs2288499 chr14:81660997 C/T cg01989461 chr14:81687754 GTF2A1 0.63 10.37 0.5 5.37e-22 Schizophrenia; CRC trans rs473651 0.935 rs35080527 chr2:239351387 T/C cg13521940 chr21:36262239 RUNX1 -0.4 -5.97 -0.31 6.12e-9 Multiple system atrophy; CRC cis rs8060686 0.920 rs2271293 chr16:67902070 A/G cg07125278 chr16:67683757 RLTPR 0.61 6.75 0.35 6.86e-11 HDL cholesterol;Metabolic syndrome; CRC cis rs6500602 0.826 rs11076831 chr16:4460133 A/G cg08645402 chr16:4508243 NA -0.55 -7.62 -0.39 2.79e-13 Schizophrenia; CRC cis rs2276314 0.802 rs4799838 chr18:33597530 T/C cg19628046 chr18:33552617 C18orf21 0.55 7.23 0.37 3.41e-12 Endometriosis;Drug-induced torsades de pointes; CRC cis rs2115536 0.730 rs12898642 chr15:80182050 T/C cg00225070 chr15:80189496 MTHFS 0.4 6.06 0.32 3.73e-9 Eosinophil counts;Eosinophil percentage of white cells;Sum eosinophil basophil counts;Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; CRC cis rs9733 0.596 rs72702536 chr1:150662574 C/T cg17724175 chr1:150552817 MCL1 0.58 9.32 0.46 1.79e-18 Tonsillectomy; CRC cis rs9311676 0.656 rs6445973 chr3:58336595 G/T cg06643156 chr3:58380774 PXK -0.43 -6.43 -0.33 4.49e-10 Systemic lupus erythematosus; CRC cis rs7829975 0.593 rs2921077 chr8:8304502 C/T cg08975724 chr8:8085496 FLJ10661 0.48 7.52 0.38 5.32e-13 Mood instability; CRC trans rs12478296 1.000 rs73007140 chr2:243010756 T/C cg18288967 chr1:45987694 PRDX1 0.61 7.08 0.36 8.96e-12 Obesity-related traits; CRC cis rs1387259 0.929 rs11168460 chr12:48597365 A/G cg24011408 chr12:48396354 COL2A1 0.43 6.18 0.32 1.87e-9 Obstructive sleep apnea trait (apnea hypopnea index); CRC cis rs7072216 0.922 rs10786415 chr10:100151266 A/G cg26618903 chr10:100175079 PYROXD2 -0.39 -6.67 -0.35 1.09e-10 Metabolite levels; CRC cis rs10791323 0.604 rs2257010 chr11:133712348 G/A cg00579200 chr11:133705235 NA -0.39 -5.6 -0.3 4.51e-8 Childhood ear infection; CRC cis rs561341 1.000 rs117029332 chr17:30266085 C/G cg00745463 chr17:30367425 LRRC37B -0.89 -9.79 -0.48 4.8e-20 Hip circumference adjusted for BMI; CRC cis rs597539 0.652 rs604524 chr11:68629929 G/A cg06112835 chr11:68658793 MRPL21 0.43 6.97 0.36 1.75e-11 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs3857067 1.000 rs6532454 chr4:95019067 G/A cg11021082 chr4:95130006 SMARCAD1 -0.38 -5.67 -0.3 3.06e-8 QT interval; CRC cis rs344364 0.602 rs2983907 chr16:1913336 C/T cg09830162 chr16:1889614 FAHD1;C16orf73 0.56 8.29 0.42 3.02e-15 Glomerular filtration rate in chronic kidney disease; CRC cis rs116095464 0.558 rs7715108 chr5:264661 A/G cg22857025 chr5:266934 NA -1.25 -16.78 -0.68 4.42e-46 Breast cancer; CRC cis rs2019137 0.936 rs902696 chr2:113954879 G/T cg21610815 chr2:113994035 PAX8;LOC654433;LOC440839 0.44 6.15 0.32 2.28e-9 Lymphocyte counts; CRC trans rs8002861 0.967 rs7999434 chr13:44482961 T/C cg17145862 chr1:211918768 LPGAT1 0.77 15.89 0.66 1.3e-42 Leprosy; CRC cis rs7917772 0.582 rs7087984 chr10:104380686 G/A cg11453585 chr10:104263688 ACTR1A;SUFU 0.8 14.47 0.62 4.68e-37 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC cis rs7814319 0.700 rs7838479 chr8:97268077 G/A cg20787634 chr8:97240163 UQCRB -0.45 -7.19 -0.37 4.34e-12 Lung function (FVC); CRC cis rs11212617 0.967 rs12272183 chr11:108077181 A/G cg12106634 chr11:108092400 ATM;NPAT 0.38 5.61 0.3 4.36e-8 Response to metformin in type 2 diabetes (glycemic); CRC cis rs4808199 0.947 rs1465695 chr19:19588546 A/C cg03709012 chr19:19516395 GATAD2A 1.01 11.92 0.55 1.85e-27 Nonalcoholic fatty liver disease; CRC trans rs7613875 0.654 rs3774751 chr3:50209053 G/T cg21665057 chr3:196295764 WDR53;FBXO45 -0.51 -7.93 -0.4 3.4e-14 Body mass index; CRC cis rs1552244 0.808 rs7615088 chr3:10035896 A/T cg02579736 chr3:10068473 FANCD2;CIDECP 0.93 12.04 0.55 6.69e-28 Alzheimer's disease; CRC cis rs10493773 0.894 rs12067749 chr1:86197922 T/C cg17807903 chr1:86174739 ZNHIT6 -0.52 -10.49 -0.5 2.07e-22 Urate levels in overweight individuals; CRC cis rs10504229 0.683 rs61201557 chr8:58138370 T/C cg04204079 chr8:58130323 NA -0.45 -5.78 -0.3 1.71e-8 Developmental language disorder (linguistic errors); CRC cis rs7725052 0.609 rs4331943 chr5:40450245 G/A cg09067459 chr5:40385259 NA -0.4 -6.61 -0.34 1.53e-10 Pediatric autoimmune diseases; CRC cis rs2075371 0.611 rs34573600 chr7:134018937 C/T cg02659138 chr7:134003124 SLC35B4 0.36 5.71 0.3 2.54e-8 Mean platelet volume; CRC trans rs1814175 0.615 rs4545557 chr11:50027329 A/C cg03929089 chr4:120376271 NA -0.88 -15.84 -0.66 2.09e-42 Height; CRC trans rs1005277 0.522 rs1208684 chr10:38093936 G/A cg23533926 chr12:111358616 MYL2 -0.45 -6.57 -0.34 1.94e-10 Extrinsic epigenetic age acceleration; CRC cis rs1707322 0.721 rs6697821 chr1:46216722 A/G cg03146154 chr1:46216737 IPP 0.68 9.92 0.48 1.88e-20 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs8060686 0.545 rs3815173 chr16:68160289 T/G cg26727032 chr16:67993705 SLC12A4 -0.56 -6.19 -0.32 1.8e-9 HDL cholesterol;Metabolic syndrome; CRC trans rs10411161 0.702 rs8110546 chr19:52383556 C/A cg22319618 chr22:45562946 NUP50 -0.68 -7.53 -0.38 4.85e-13 Breast cancer; CRC trans rs9326248 1.000 rs664082 chr11:117071070 C/G cg18755114 chr2:209119030 IDH1 -0.41 -6.18 -0.32 1.9e-9 Blood protein levels; CRC cis rs4604732 0.678 rs74154674 chr1:247625685 C/T cg12754571 chr1:247694271 LOC148824;OR2C3 0.41 5.78 0.3 1.74e-8 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CRC cis rs854765 0.547 rs9896837 chr17:17924868 A/G cg24612305 chr17:17875800 TOM1L2;LRRC48 0.77 13.87 0.61 8.95e-35 Total body bone mineral density; CRC cis rs992157 0.798 rs4674284 chr2:219161241 C/T cg04880052 chr2:219191631 PNKD -0.44 -6.93 -0.36 2.24e-11 Colorectal cancer; CRC cis rs13108904 0.967 rs12502916 chr4:1276349 G/A cg00684032 chr4:1343700 KIAA1530 -0.42 -6.25 -0.33 1.26e-9 Obesity-related traits; CRC cis rs1401999 0.606 rs939335 chr3:183745663 A/G cg01324343 chr3:183735012 ABCC5 0.75 13.63 0.6 7.34e-34 Anterior chamber depth; CRC cis rs12580194 0.556 rs7955088 chr12:55732963 G/T cg23425280 chr12:56401806 NA 0.47 5.88 0.31 9.99e-9 Cancer; CRC cis rs9443645 0.869 rs9443621 chr6:79576499 A/G cg11833968 chr6:79620685 NA -0.36 -6.33 -0.33 8e-10 Intelligence (multi-trait analysis); CRC cis rs10992471 0.651 rs10124058 chr9:95522882 G/A cg14631576 chr9:95140430 CENPP -0.38 -6.76 -0.35 6.3e-11 Visceral adipose tissue/subcutaneous adipose tissue ratio; CRC cis rs9549328 0.670 rs61963562 chr13:113616523 T/G cg20742385 chr13:113633654 MCF2L 0.55 9.39 0.46 1.01e-18 Systolic blood pressure; CRC cis rs6840360 1.000 rs6535813 chr4:152599652 A/T cg09659197 chr4:152720779 NA 0.52 11.2 0.53 7.17e-25 Intelligence (multi-trait analysis); CRC cis rs3789045 0.685 rs12036042 chr1:204469314 T/C cg17419461 chr1:204415978 PIK3C2B -0.57 -7.95 -0.4 3.06e-14 Educational attainment (college completion); CRC cis rs2635047 0.601 rs2684842 chr18:44725289 A/G cg19077165 chr18:44547161 KATNAL2 0.4 6.08 0.32 3.26e-9 Educational attainment; CRC cis rs2651899 0.872 rs207199 chr1:3076857 T/G cg22674798 chr1:3096360 PRDM16 0.35 7.41 0.38 1.04e-12 Migraine; CRC cis rs6088580 0.602 rs6059834 chr20:33019299 A/G cg24642439 chr20:33292090 TP53INP2 0.37 6.27 0.33 1.13e-9 Glomerular filtration rate (creatinine); CRC cis rs6500602 0.627 rs934929 chr16:4587789 A/G cg14951292 chr16:4525986 HMOX2;NMRAL1 -0.61 -8.86 -0.44 5.28e-17 Schizophrenia; CRC cis rs1552244 0.515 rs7613004 chr3:9999913 A/C cg08888203 chr3:10149979 C3orf24 0.46 7.21 0.37 3.9e-12 Alzheimer's disease; CRC trans rs9329221 0.772 rs7824675 chr8:10243418 G/T cg08071915 chr8:12219732 FAM66A 0.33 6.08 0.32 3.33e-9 Neuroticism; CRC cis rs17125944 0.686 rs73304351 chr14:53375140 G/A cg00686598 chr14:53173677 PSMC6 0.71 5.89 0.31 9.63e-9 Alzheimer's disease (late onset); CRC cis rs908922 0.676 rs10888491 chr1:152492622 A/G cg09873164 chr1:152488093 CRCT1 0.37 6.26 0.33 1.18e-9 Hair morphology; CRC cis rs7811142 0.830 rs1063945 chr7:99930447 C/T cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.68 9.04 0.45 1.41e-17 Platelet count; CRC cis rs9309473 0.687 rs7576824 chr2:73611281 C/T cg20560298 chr2:73613845 ALMS1 0.52 7.03 0.36 1.21e-11 Metabolite levels; CRC cis rs9858542 0.903 rs11917431 chr3:49644012 C/T cg00383909 chr3:49044727 WDR6 0.47 5.82 0.31 1.43e-8 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs12908161 0.959 rs17598603 chr15:85200211 C/G cg17507749 chr15:85114479 UBE2QP1 -0.62 -8.67 -0.43 1.95e-16 Schizophrenia; CRC cis rs12079745 0.793 rs12073439 chr1:169284482 A/G cg09363564 chr1:169337483 NME7;BLZF1 -0.91 -5.88 -0.31 1.03e-8 QT interval; CRC cis rs10504229 0.683 rs67048677 chr8:58140023 C/G cg21724239 chr8:58056113 NA 0.49 6.81 0.35 4.75e-11 Developmental language disorder (linguistic errors); CRC cis rs3820068 0.581 rs72645895 chr1:15931709 G/A cg24675056 chr1:15929824 NA 0.49 6.77 0.35 5.87e-11 Systolic blood pressure; CRC cis rs3020333 1.000 rs3020332 chr6:152008924 C/T cg22157087 chr6:152012887 ESR1 0.53 7.98 0.4 2.49e-14 Total body bone mineral density; CRC cis rs2032447 0.702 rs199753 chr6:26001888 G/A cg12588279 chr6:26043732 HIST1H2BB 0.51 7.19 0.37 4.31e-12 Intelligence (multi-trait analysis); CRC cis rs10493773 0.609 rs11161651 chr1:86177816 A/G cg23216685 chr1:86174607 ZNHIT6 -0.27 -6.42 -0.33 4.66e-10 Urate levels in overweight individuals; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg19711724 chr3:19188166 NA 0.45 6.36 0.33 6.9e-10 Thyroid stimulating hormone; CRC cis rs501120 0.810 rs541483 chr10:44746395 A/G cg09554077 chr10:44749378 NA 0.87 11.81 0.55 4.44e-27 Coronary artery disease;Coronary heart disease; CRC cis rs6503525 0.701 rs28618095 chr17:38109075 T/C cg17344932 chr17:38183730 MED24;SNORD124 -0.58 -9.09 -0.45 9.72e-18 Asthma; CRC cis rs2811415 0.597 rs13094572 chr3:127772785 G/A cg13719885 chr3:127795394 NA -0.4 -6.05 -0.32 3.83e-9 Lung function (FEV1/FVC); CRC trans rs3794271 0.706 rs9971816 chr12:20826911 C/T cg04633409 chr12:44195947 TWF1 0.41 6.16 0.32 2.13e-9 Response to TNF-alpha inhibitors in rheumatoid arthritis; CRC cis rs698833 0.819 rs698772 chr2:44580634 G/A cg04920474 chr2:44395004 PPM1B 0.42 6.27 0.33 1.15e-9 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; CRC cis rs8180040 0.932 rs62248599 chr3:47516728 G/A cg02527881 chr3:46936655 PTH1R 0.38 7.08 0.36 8.93e-12 Colorectal cancer; CRC cis rs4713118 0.591 rs2056924 chr6:27690174 G/A cg15845792 chr6:28175446 NA 0.59 8.4 0.42 1.31e-15 Parkinson's disease; CRC cis rs10504229 0.724 rs73603871 chr8:58107612 A/G cg02290350 chr8:58132656 NA -0.59 -8.02 -0.4 1.88e-14 Developmental language disorder (linguistic errors); CRC cis rs12575642 0.660 rs58632573 chr11:63896299 C/T cg19465662 chr11:63993652 NUDT22;TRPT1 0.73 8.98 0.44 2.15e-17 Attention deficit hyperactivity disorder; CRC cis rs294883 0.739 rs1504256 chr6:159731036 A/C cg14500486 chr6:159655392 FNDC1 -0.34 -5.93 -0.31 7.85e-9 Coronary artery disease; CRC cis rs7666738 0.830 rs1365458 chr4:98950961 C/T cg17366294 chr4:99064904 C4orf37 0.43 7.45 0.38 8.28e-13 Colonoscopy-negative controls vs population controls; CRC cis rs9916302 0.904 rs55660616 chr17:37684990 C/A cg03013999 chr17:37608204 MED1 0.45 6.86 0.35 3.45e-11 Glomerular filtration rate (creatinine); CRC cis rs9487051 0.802 rs6910696 chr6:109592329 A/T cg12927641 chr6:109611667 NA -0.37 -6.71 -0.35 8.55e-11 Reticulocyte fraction of red cells; CRC cis rs10751667 0.643 rs10794350 chr11:946070 A/G cg01483505 chr11:975446 AP2A2 0.43 6.94 0.36 2.05e-11 Alzheimer's disease (late onset); CRC cis rs6433857 0.594 rs1406257 chr2:181521345 A/G cg23363182 chr2:181467187 NA -0.48 -7.38 -0.38 1.29e-12 Body mass index; CRC cis rs524281 0.506 rs560393 chr11:66005477 A/G cg16950941 chr11:66035639 RAB1B -0.5 -6.12 -0.32 2.62e-9 Electroencephalogram traits; CRC cis rs10206020 0.879 rs72778007 chr2:1573178 C/T cg12573674 chr2:1569213 NA -0.82 -10.96 -0.52 5.02e-24 IgG glycosylation; CRC cis rs1552244 1.000 rs112847840 chr3:10101652 C/T cg16606324 chr3:10149918 C3orf24 0.72 9.82 0.48 3.92e-20 Alzheimer's disease; CRC cis rs4304924 0.500 rs2281856 chr13:79207644 C/T cg01819759 chr13:79234251 RNF219 -0.44 -5.98 -0.31 5.66e-9 Large artery stroke; CRC cis rs3796352 1.000 rs11713206 chr3:52999243 A/G cg07884673 chr3:53033167 SFMBT1 0.79 6.22 0.32 1.51e-9 Immune reponse to smallpox (secreted IL-2); CRC cis rs9393777 0.920 rs35120058 chr6:27358166 A/G cg26958806 chr6:27640298 NA 0.85 5.63 0.3 3.79e-8 Intelligence (multi-trait analysis); CRC cis rs7487075 0.780 rs1873793 chr12:46761324 A/G cg07601320 chr12:47219841 SLC38A4 -0.27 -5.68 -0.3 3.04e-8 Itch intensity from mosquito bite; CRC cis rs12541635 0.966 rs7839239 chr8:107020406 C/T cg10147462 chr8:107024639 NA 0.42 7.05 0.36 1.07e-11 Age of smoking initiation; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg26072759 chr17:75277365 SEPT9 0.39 6.22 0.32 1.47e-9 Intelligence (multi-trait analysis); CRC cis rs2243480 1.000 rs1979823 chr7:65704613 G/A cg25985355 chr7:65971099 NA 0.51 5.75 0.3 2.08e-8 Diabetic kidney disease; CRC cis rs17767392 0.958 rs4902942 chr14:72140659 A/T cg13720639 chr14:72061746 SIPA1L1 0.56 7.01 0.36 1.38e-11 Mitral valve prolapse; CRC cis rs13191362 1.000 rs13199223 chr6:163001083 T/C cg23758597 chr6:163146217 PARK2 -0.55 -6.12 -0.32 2.61e-9 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs311392 1.000 rs2671804 chr8:55088853 C/T cg20636351 chr8:55087400 NA -0.34 -6.07 -0.32 3.5e-9 Pelvic organ prolapse (moderate/severe); CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg22190833 chr7:150929518 CHPF2 -0.33 -6.02 -0.31 4.58e-9 Myopia (pathological); CRC cis rs9311676 0.632 rs62258078 chr3:58363432 G/A cg06643156 chr3:58380774 PXK 0.44 6.8 0.35 4.98e-11 Systemic lupus erythematosus; CRC cis rs853679 0.517 rs4713146 chr6:28111536 A/T cg18032046 chr6:28092343 ZSCAN16 -0.51 -5.93 -0.31 7.47e-9 Depression; CRC trans rs926326 0.789 rs35033684 chr6:25507639 T/G cg25354657 chr11:129991445 APLP2 -0.43 -6.34 -0.33 7.39e-10 Platelet count; CRC cis rs875971 0.862 rs11769079 chr7:65842128 G/A cg00343986 chr7:65444356 GUSB 0.41 5.87 0.31 1.09e-8 Aortic root size; CRC cis rs853679 0.517 rs9348794 chr6:28117757 T/A cg21251018 chr6:28226885 NKAPL 0.48 6.17 0.32 2.02e-9 Depression; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg05830473 chr16:58718573 SLC38A7 0.42 6.12 0.32 2.71e-9 Intelligence (multi-trait analysis); CRC cis rs9326248 0.520 rs236919 chr11:117095361 A/G cg10130564 chr11:117069849 TAGLN 0.3 5.81 0.31 1.47e-8 Blood protein levels; CRC cis rs9611565 0.512 rs139560 chr22:42194962 A/G cg03806693 chr22:41940476 POLR3H -1.08 -13.31 -0.59 1.25e-32 Vitiligo; CRC cis rs6952808 0.717 rs6967442 chr7:1926090 A/G cg02951883 chr7:2050386 MAD1L1 -0.58 -9.75 -0.47 6.58e-20 Bipolar disorder and schizophrenia; CRC cis rs2243480 1.000 rs160633 chr7:65528228 T/C cg25985355 chr7:65971099 NA -0.5 -5.8 -0.3 1.57e-8 Diabetic kidney disease; CRC cis rs7666738 0.830 rs13110410 chr4:98920018 T/C cg17366294 chr4:99064904 C4orf37 0.43 7.25 0.37 2.97e-12 Colonoscopy-negative controls vs population controls; CRC cis rs9916302 0.904 rs8076494 chr17:37516722 A/G cg07936489 chr17:37558343 FBXL20 0.79 11.64 0.54 1.79e-26 Glomerular filtration rate (creatinine); CRC cis rs365302 0.767 rs364581 chr6:159613190 G/A cg14500486 chr6:159655392 FNDC1 0.55 8.35 0.42 1.98e-15 Coronary heart disease; CRC cis rs9372498 0.536 rs9320660 chr6:118956827 A/T cg24463073 chr6:118973353 C6orf204 0.48 6.21 0.32 1.61e-9 Diastolic blood pressure; CRC cis rs4516970 0.655 rs73781666 chr6:160206106 G/A cg19482086 chr6:160211437 TCP1;MRPL18 -0.73 -5.68 -0.3 3.03e-8 Iron status biomarkers; CRC cis rs7527798 0.592 rs6667238 chr1:207822856 G/A cg09232269 chr1:207846808 CR1L -0.47 -7.66 -0.39 2.16e-13 Erythrocyte sedimentation rate; CRC cis rs12586317 0.547 rs78609489 chr14:35497285 T/C cg05294307 chr14:35346193 BAZ1A -0.71 -7.79 -0.39 8.55e-14 Psoriasis; CRC cis rs933688 0.938 rs7708782 chr5:90718517 T/C cg26981201 chr5:90679533 LOC100129716;ARRDC3 1.02 15.59 0.65 1.97e-41 Smoking behavior; CRC cis rs9549367 0.713 rs576463 chr13:113846614 C/T cg24300038 chr13:113819356 PROZ 0.51 6.69 0.35 9.53e-11 Platelet distribution width; CRC cis rs6541297 1.000 rs6674744 chr1:230279011 C/T cg20703242 chr1:230279135 GALNT2 0.51 7.71 0.39 1.48e-13 Coronary artery disease; CRC cis rs9311474 0.508 rs1570 chr3:52586682 T/A cg05573699 chr3:52720067 GNL3;PBRM1 -0.44 -6.45 -0.33 4.06e-10 Electroencephalogram traits; CRC trans rs459571 0.959 rs2073818 chr9:136918662 C/A cg09836344 chr4:1243392 C4orf42;CTBP1 -0.8 -11.09 -0.52 1.72e-24 Platelet distribution width; CRC cis rs4722166 0.568 rs1880241 chr7:22759469 A/G cg26061582 chr7:22766209 IL6 0.39 6.19 0.32 1.79e-9 Lung cancer; CRC cis rs6952808 1.000 rs6957894 chr7:1887362 G/A cg21782813 chr7:2030301 MAD1L1 0.4 6.79 0.35 5.14e-11 Bipolar disorder and schizophrenia; CRC cis rs9467711 0.606 rs9393715 chr6:26375645 G/A cg16898833 chr6:26189333 HIST1H4D 0.74 6.18 0.32 1.94e-9 Autism spectrum disorder or schizophrenia; CRC cis rs1218582 0.510 rs2878411 chr1:154823545 C/T cg09359103 chr1:154839909 KCNN3 -0.56 -8.4 -0.42 1.35e-15 Prostate cancer; CRC cis rs7208859 0.673 rs9913782 chr17:29237384 A/G cg13385521 chr17:29058706 SUZ12P 0.69 7.99 0.4 2.27e-14 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC trans rs1973993 0.669 rs510552 chr1:96891671 A/G cg10631902 chr5:14652156 NA 0.62 12.42 0.56 2.59e-29 Weight; CRC cis rs735539 1.000 rs9506537 chr13:21280410 T/C cg27499820 chr13:21296301 IL17D -0.38 -6.16 -0.32 2.16e-9 Dental caries; CRC cis rs7918232 0.662 rs10741125 chr10:27288925 G/A cg14240646 chr10:27532245 ACBD5 -0.65 -7.11 -0.36 7.38e-12 Breast cancer; CRC cis rs10540 0.841 rs35601764 chr11:532923 A/C cg15790184 chr11:494944 RNH1 0.57 5.71 0.3 2.59e-8 Body mass index; CRC cis rs4638749 0.677 rs6713634 chr2:108827907 T/G cg25838818 chr2:108905173 SULT1C2 -0.34 -5.71 -0.3 2.52e-8 Blood pressure; CRC cis rs7647973 1.000 rs7647973 chr3:49510931 G/A cg07690219 chr3:49449608 TCTA;RHOA 0.53 5.81 0.31 1.46e-8 Menarche (age at onset); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg12989020 chr6:157098657 ARID1B 0.44 6.17 0.32 1.99e-9 Response to antipsychotic treatment; CRC cis rs35146811 0.586 rs12705067 chr7:99594726 T/C cg13334819 chr7:99746414 C7orf59 -0.45 -6.16 -0.32 2.11e-9 Coronary artery disease; CRC cis rs6968419 0.714 rs1048508 chr7:115892650 G/T cg02561103 chr7:115862891 TES 0.42 6.36 0.33 6.81e-10 Intraocular pressure; CRC cis rs13256369 0.755 rs12680167 chr8:8562467 A/G cg06671706 chr8:8559999 CLDN23 0.62 9.12 0.45 7.86e-18 Obesity-related traits; CRC cis rs17428704 0.649 rs6883134 chr5:14415590 A/G cg05138787 chr5:14405925 TRIO -0.6 -5.99 -0.31 5.59e-9 Electroencephalogram traits; CRC cis rs644799 0.710 rs10831429 chr11:95508524 C/A cg03916912 chr11:95522834 CEP57;FAM76B 0.85 15.48 0.65 5.58e-41 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs4713675 0.584 rs9394163 chr6:33682414 A/G cg14003231 chr6:33640908 ITPR3 0.49 7.95 0.4 2.97e-14 Plateletcrit; CRC cis rs9937943 0.615 rs35495670 chr16:74610422 T/C cg01733217 chr16:74700730 RFWD3 0.74 8.33 0.42 2.27e-15 Neutrophil percentage of white cells; CRC cis rs6456156 0.967 rs150108 chr6:167513153 C/T cg07741184 chr6:167504864 NA 0.35 6.01 0.31 4.88e-9 Primary biliary cholangitis; CRC cis rs10504229 0.861 rs67042991 chr8:58191749 G/C cg05313129 chr8:58192883 C8orf71 -0.47 -6.99 -0.36 1.49e-11 Developmental language disorder (linguistic errors); CRC cis rs6546550 0.867 rs7592647 chr2:70139134 C/T cg02498382 chr2:70120550 SNRNP27 -0.55 -9.22 -0.45 3.61e-18 Prevalent atrial fibrillation; CRC cis rs7043114 0.525 rs2516567 chr9:95187418 C/T cg14631576 chr9:95140430 CENPP -0.31 -5.89 -0.31 9.31e-9 Height; CRC cis rs1983891 0.955 rs4714480 chr6:41520891 T/C cg20194872 chr6:41519635 FOXP4 0.42 6.02 0.31 4.74e-9 Prostate cancer; CRC cis rs9916302 0.706 rs8182252 chr17:37727950 T/C cg00129232 chr17:37814104 STARD3 0.54 7.1 0.36 7.51e-12 Glomerular filtration rate (creatinine); CRC cis rs8067545 0.641 rs203457 chr17:19818338 A/C cg04132472 chr17:19861366 AKAP10 -0.37 -5.81 -0.31 1.47e-8 Schizophrenia; CRC cis rs4076764 0.914 rs6689760 chr1:163358704 A/G cg06092702 chr1:163392909 NA 0.56 8.62 0.43 2.86e-16 Motion sickness; CRC cis rs7659604 0.539 rs7686200 chr4:122764553 C/T cg20573242 chr4:122745356 CCNA2 0.55 8.3 0.42 2.76e-15 Type 2 diabetes; CRC cis rs7945705 0.846 rs4929912 chr11:8816695 A/G cg21881798 chr11:8931708 C11orf17;ST5 -0.46 -6.55 -0.34 2.26e-10 Hemoglobin concentration; CRC cis rs832540 0.629 rs10055224 chr5:56081201 C/T cg24531977 chr5:56204891 C5orf35 0.5 7.63 0.39 2.5e-13 Coronary artery disease; CRC cis rs4713118 0.513 rs1225591 chr6:28148752 G/A cg12273811 chr6:28175739 NA 0.62 9.03 0.45 1.52e-17 Parkinson's disease; CRC cis rs6701037 0.681 rs1894709 chr1:175132371 G/T cg00321850 chr1:175162397 KIAA0040 -0.41 -6.71 -0.35 8.42e-11 Alcohol dependence; CRC cis rs79349575 0.783 rs12603969 chr17:47034419 A/G cg00947319 chr17:47005597 UBE2Z -0.34 -5.69 -0.3 2.83e-8 Type 2 diabetes; CRC cis rs6921919 0.583 rs9468354 chr6:28337801 T/A cg21251018 chr6:28226885 NKAPL 0.4 6.09 0.32 3.12e-9 Autism spectrum disorder or schizophrenia; CRC cis rs9894429 1.000 rs9674872 chr17:79581931 T/A cg21984481 chr17:79567631 NPLOC4 -0.53 -9.8 -0.48 4.52e-20 Eye color traits; CRC cis rs7589728 0.514 rs78204719 chr2:88460747 G/C cg18490616 chr2:88469792 THNSL2 0.59 5.99 0.31 5.51e-9 Plasma clusterin levels; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg04297258 chr16:88772664 RNF166;CTU2 0.45 6.33 0.33 8.16e-10 Response to antipsychotic treatment; CRC cis rs11741688 0.557 rs6897783 chr5:178330574 G/A cg20935368 chr5:178288625 ZNF354B 0.43 7.01 0.36 1.32e-11 Sleep duration; CRC cis rs10489202 0.583 rs203782 chr1:167882386 A/G cg24449463 chr1:168025552 DCAF6 0.6 9.16 0.45 5.79e-18 Schizophrenia; CRC cis rs9463078 0.585 rs1521355 chr6:44932755 T/C cg25276700 chr6:44698697 NA -0.23 -5.63 -0.3 3.94e-8 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; CRC cis rs36715 1.000 rs36697 chr5:127549613 A/G cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.61 7.98 0.4 2.52e-14 Breast cancer; CRC cis rs1799949 1.000 rs11079056 chr17:41300799 C/A cg01879757 chr17:41196368 BRCA1 -0.44 -6.67 -0.35 1.06e-10 Menopause (age at onset); CRC cis rs35110281 0.715 rs969060 chr21:45080852 T/G cg01579765 chr21:45077557 HSF2BP -0.4 -7.81 -0.4 7.83e-14 Mean corpuscular volume; CRC cis rs2573652 1.000 rs1469828 chr15:100517210 A/C cg00587665 chr15:100533223 ADAMTS17 -0.34 -5.78 -0.3 1.76e-8 Height; CRC cis rs743757 1.000 rs2236973 chr3:50474284 T/C cg09545109 chr3:50388910 TUSC4;CYB561D2 0.46 6.55 0.34 2.15e-10 Diastolic blood pressure; CRC cis rs3858526 0.584 rs10769271 chr11:5860572 T/C cg26762873 chr11:5879799 OR52E8 -0.48 -7.2 -0.37 4.19e-12 DNA methylation (variation); CRC cis rs6951245 1.000 rs11763020 chr7:1060288 C/T cg20603222 chr7:1096387 C7orf50;GPR146 -0.66 -7.79 -0.39 8.88e-14 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC trans rs7267979 0.816 rs1044573 chr20:25206654 A/G cg17903999 chr18:56338584 MALT1 -0.4 -6.61 -0.34 1.56e-10 Liver enzyme levels (alkaline phosphatase); CRC cis rs12681287 0.888 rs13042 chr8:87484913 G/A cg27223183 chr8:87520930 FAM82B -0.45 -6.52 -0.34 2.65e-10 Caudate activity during reward; CRC cis rs4774899 0.866 rs2431023 chr15:57553832 A/T cg08128148 chr15:57256372 TCF12 -0.4 -5.66 -0.3 3.33e-8 Urinary tract infection frequency; CRC trans rs35110281 0.626 rs162389 chr21:44936227 T/C cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.42 6.68 0.35 1.02e-10 Mean corpuscular volume; CRC cis rs11212617 0.935 rs186591 chr11:108200142 T/G cg14761454 chr11:108092087 ATM;NPAT 0.42 6.3 0.33 9.78e-10 Response to metformin in type 2 diabetes (glycemic); CRC cis rs9457247 0.624 rs2239826 chr6:167504880 T/C cg07741184 chr6:167504864 NA 0.51 8.74 0.43 1.23e-16 Crohn's disease; CRC cis rs11971779 0.617 rs66652773 chr7:139109573 C/T cg23387468 chr7:139079360 LUC7L2 0.41 7.05 0.36 1.04e-11 Diisocyanate-induced asthma; CRC cis rs8050755 0.649 rs2516737 chr16:2101749 A/G cg04515572 chr16:2107413 TSC2 0.67 7.13 0.37 6.49e-12 Major depressive disorder; CRC cis rs67478160 0.619 rs1040813 chr14:104306696 T/C cg01849466 chr14:104193079 ZFYVE21 -0.47 -8.36 -0.42 1.75e-15 Schizophrenia; CRC cis rs6951245 1.000 rs78185801 chr7:1096367 G/A cg21664854 chr7:1097933 C7orf50;GPR146 0.78 8.81 0.44 7.57e-17 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs727505 0.721 rs55890146 chr7:124755461 A/T cg23710748 chr7:124431027 NA -0.67 -11.37 -0.53 1.66e-25 Lewy body disease; CRC cis rs9814567 0.929 rs13088413 chr3:134309977 T/C cg06109529 chr3:134205091 CEP63;ANAPC13 0.82 11.95 0.55 1.43e-27 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs4555082 0.874 rs1008628 chr14:105722726 T/C cg13114125 chr14:105738426 BRF1 -0.8 -11.81 -0.55 4.54e-27 Mean platelet volume;Platelet distribution width; CRC cis rs13191362 0.507 rs2849511 chr6:163139050 C/G cg06582575 chr6:163149167 PACRG;PARK2 -0.59 -9.08 -0.45 1.01e-17 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs6952808 0.692 rs60755037 chr7:2030104 G/A cg00106254 chr7:1943704 MAD1L1 -0.56 -8.2 -0.41 5.62e-15 Bipolar disorder and schizophrenia; CRC cis rs6089584 0.816 rs6061410 chr20:60625329 A/G cg23262073 chr20:60523788 NA -0.48 -7.6 -0.39 3.19e-13 Body mass index; CRC cis rs7618915 0.501 rs2289247 chr3:52727257 C/T cg18099408 chr3:52552593 STAB1 -0.47 -7.89 -0.4 4.54e-14 Bipolar disorder; CRC trans rs7580658 0.614 rs7585198 chr2:127962635 C/T cg24453429 chr1:161136002 PPOX -0.44 -6.05 -0.32 4e-9 Protein C levels; CRC cis rs9611565 0.512 rs132784 chr22:42052363 G/A cg06634786 chr22:41940651 POLR3H 0.55 6.09 0.32 3.2e-9 Vitiligo; CRC cis rs7224737 1.000 rs12603330 chr17:40290589 T/A cg20291162 chr17:40259547 DHX58 -0.55 -8.01 -0.4 2.06e-14 Fibrinogen levels; CRC cis rs644799 1.000 rs516551 chr11:95588626 C/T cg03916912 chr11:95522834 CEP57;FAM76B 0.97 18.82 0.72 3.84e-54 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs4713118 0.739 rs2893931 chr6:27748010 G/A cg08798685 chr6:27730294 NA -0.48 -6.66 -0.34 1.12e-10 Parkinson's disease; CRC trans rs3749237 0.964 rs7431078 chr3:49808190 G/A cg21659725 chr3:3221576 CRBN 0.56 7.88 0.4 4.96e-14 Resting heart rate; CRC cis rs9911578 0.935 rs117819974 chr17:57002324 C/T cg12560992 chr17:57184187 TRIM37 0.92 17.18 0.69 1.12e-47 Intelligence (multi-trait analysis); CRC cis rs2836950 0.520 rs8133927 chr21:40689961 G/T cg06238570 chr21:40685208 BRWD1 -0.6 -8.64 -0.43 2.48e-16 Menarche (age at onset); CRC cis rs9341808 0.754 rs3805907 chr6:80973665 A/G cg08355045 chr6:80787529 NA -0.39 -6.49 -0.34 3.2e-10 Sitting height ratio; CRC cis rs6831352 0.918 rs2851253 chr4:100043505 G/T cg13256891 chr4:100009986 ADH5 -0.64 -8.75 -0.43 1.11e-16 Alcohol dependence; CRC cis rs6951245 1.000 rs80212261 chr7:1114012 C/T cg03188948 chr7:1209495 NA 0.64 6.65 0.34 1.2e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs3736485 0.844 rs7174495 chr15:51895291 A/G cg08986416 chr15:51914746 DMXL2 -0.49 -6.94 -0.36 2.11e-11 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs853679 0.517 rs17774663 chr6:28120898 G/A cg18032046 chr6:28092343 ZSCAN16 -0.51 -5.93 -0.31 7.47e-9 Depression; CRC cis rs1552244 0.935 rs7652190 chr3:10105150 G/A cg16606324 chr3:10149918 C3orf24 0.71 9.38 0.46 1.1e-18 Alzheimer's disease; CRC cis rs3026101 0.671 rs12602074 chr17:5302778 T/C cg25236894 chr17:5323110 RPAIN;NUP88 0.42 6.9 0.36 2.74e-11 Body mass index; CRC cis rs9291683 0.526 rs7695555 chr4:10001656 T/C cg00071950 chr4:10020882 SLC2A9 0.51 8.91 0.44 3.51e-17 Bone mineral density; CRC cis rs2502731 1.000 rs2502731 chr9:130976557 A/G cg13642260 chr9:130955380 CIZ1 -0.51 -8.11 -0.41 9.9e-15 Attention deficit hyperactivity disorder; CRC trans rs7873102 0.702 rs7028020 chr9:38007747 C/T cg14993530 chr1:245027115 HNRNPU -0.39 -6.0 -0.31 5.11e-9 Brain structure; CRC cis rs72634258 0.519 rs36040967 chr1:7931804 A/G cg26816564 chr1:7831052 VAMP3 0.8 9.0 0.44 1.82e-17 Inflammatory bowel disease; CRC cis rs3736485 0.932 rs4774592 chr15:51778879 C/T cg08986416 chr15:51914746 DMXL2 -0.45 -6.51 -0.34 2.74e-10 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs763121 0.853 rs5750626 chr22:38977890 G/C cg06022373 chr22:39101656 GTPBP1 0.74 10.8 0.51 1.72e-23 Menopause (age at onset); CRC trans rs1455244 0.700 rs7229302 chr18:11508904 G/T cg13253660 chr19:53837494 ZNF845 0.38 5.97 0.31 6.09e-9 Schizophrenia; CRC cis rs853679 0.585 rs201000 chr6:27809159 C/T cg06470822 chr6:28175283 NA 0.62 6.81 0.35 4.6e-11 Depression; CRC cis rs4819052 0.851 rs7276103 chr21:46666078 G/A cg02159808 chr21:46707872 POFUT2;LOC642852 0.45 6.18 0.32 1.9e-9 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs9457247 1.000 rs9457247 chr6:167392174 C/T cg23791538 chr6:167370224 RNASET2 -0.38 -5.97 -0.31 6.08e-9 Crohn's disease; CRC cis rs9291683 0.527 rs11727087 chr4:10096020 A/G cg11266682 chr4:10021025 SLC2A9 0.47 9.05 0.45 1.26e-17 Bone mineral density; CRC cis rs7772486 0.754 rs6906258 chr6:146089356 A/G cg05347473 chr6:146136440 FBXO30 -0.38 -5.69 -0.3 2.77e-8 Lobe attachment (rater-scored or self-reported); CRC trans rs17780086 0.527 rs72827712 chr17:30538600 A/G cg27661571 chr11:113659931 NA -0.93 -9.31 -0.46 1.85e-18 Height; CRC cis rs11229555 0.645 rs61889554 chr11:58424081 C/A cg15696309 chr11:58395628 NA -0.74 -8.03 -0.4 1.81e-14 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; CRC trans rs10504229 1.000 rs72650899 chr8:58180525 G/T cg04077850 chr5:125800366 GRAMD3 0.37 6.27 0.33 1.15e-9 Developmental language disorder (linguistic errors); CRC cis rs853679 0.517 rs1904841 chr6:28108085 C/T cg02683197 chr6:28174875 NA 0.88 10.9 0.52 7.78e-24 Depression; CRC cis rs12477438 0.501 rs2632260 chr2:99771590 G/T cg14399236 chr2:99771627 LIPT1;TSGA10 0.83 14.8 0.63 2.35e-38 Chronic sinus infection; CRC cis rs4665809 0.590 rs7579504 chr2:26439995 T/C cg26119090 chr2:26468346 HADHA;HADHB -1.06 -15.5 -0.65 4.69e-41 Gut microbiome composition (summer); CRC cis rs4638749 1.000 rs2123694 chr2:108857505 A/G cg25838818 chr2:108905173 SULT1C2 -0.39 -6.22 -0.32 1.5e-9 Blood pressure; CRC cis rs1355223 0.506 rs1509660 chr11:34865017 A/G cg11058730 chr11:34937778 PDHX;APIP -0.43 -6.07 -0.32 3.52e-9 Systemic lupus erythematosus and Systemic sclerosis; CRC cis rs10865541 0.869 rs6548162 chr2:3434332 C/T cg22182287 chr2:3452347 TTC15 0.37 5.67 0.3 3.12e-8 Obesity-related traits; CRC cis rs651907 0.557 rs13069443 chr3:101373305 C/T cg11279151 chr3:101281821 RG9MTD1 -0.57 -7.74 -0.39 1.25e-13 Colorectal cancer; CRC cis rs2370759 1.000 rs2225152 chr10:32574759 T/C cg01819863 chr10:32635814 EPC1 1.07 12.57 0.57 7.19e-30 Sexual dysfunction (female); CRC cis rs4563143 0.663 rs2218396 chr19:29236392 C/T cg03161606 chr19:29218774 NA 0.6 7.98 0.4 2.52e-14 Methadone dose in opioid dependence; CRC cis rs2762353 0.595 rs12207313 chr6:25741027 G/C cg03517284 chr6:25882590 NA 0.74 10.48 0.5 2.24e-22 Blood metabolite levels; CRC cis rs2404602 1.000 rs4886818 chr15:76880939 G/A cg03037974 chr15:76606532 NA 0.6 9.93 0.48 1.7e-20 Blood metabolite levels; CRC cis rs9649213 0.593 rs6967576 chr7:98016373 A/G cg21770322 chr7:97807741 LMTK2 -0.47 -7.54 -0.38 4.66e-13 Prostate cancer (SNP x SNP interaction); CRC cis rs12348691 0.503 rs1348386 chr9:100612807 A/G cg13688889 chr9:100608707 NA -0.49 -6.07 -0.32 3.55e-9 Alopecia areata; CRC cis rs10484885 0.553 rs72911820 chr6:90281934 G/A cg13799429 chr6:90582589 CASP8AP2 -0.58 -6.42 -0.33 4.79e-10 QRS interval (sulfonylurea treatment interaction); CRC cis rs7223966 1.000 rs11658740 chr17:61751069 A/G cg23090583 chr17:61904693 PSMC5;FTSJ3 0.47 5.84 0.31 1.26e-8 Hip circumference adjusted for BMI;Body mass index; CRC cis rs9303401 0.659 rs7216648 chr17:56790858 C/T cg10487724 chr17:56770010 TEX14;RAD51C 0.79 10.0 0.48 1.01e-20 Cognitive test performance; CRC cis rs1799949 0.929 rs799906 chr17:41278116 T/C cg07153921 chr17:41440717 NA -0.38 -5.74 -0.3 2.13e-8 Menopause (age at onset); CRC cis rs1150668 0.796 rs2531825 chr6:28349264 C/T cg06470822 chr6:28175283 NA 0.5 7.28 0.37 2.45e-12 Pubertal anthropometrics; CRC cis rs4919694 1.000 rs11191439 chr10:104638723 C/T cg04362960 chr10:104952993 NT5C2 -1.12 -10.15 -0.49 3e-21 Arsenic metabolism; CRC cis rs9858542 0.537 rs56038006 chr3:49362369 C/T cg00383909 chr3:49044727 WDR6 0.67 6.96 0.36 1.82e-11 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs11098499 1.000 rs28374891 chr4:120183550 G/A cg24375607 chr4:120327624 NA 0.44 6.82 0.35 4.4e-11 Corneal astigmatism; CRC cis rs875971 0.545 rs73150604 chr7:65945532 T/A cg03233332 chr7:66118400 NA -0.41 -5.63 -0.3 3.93e-8 Aortic root size; CRC trans rs587242 1.000 rs12740202 chr1:96905594 G/A cg10631902 chr5:14652156 NA 0.44 6.84 0.35 3.84e-11 Body mass index (joint analysis main effects and physical activity interaction);Body mass index in physically inactive individuals;Body mass index; CRC trans rs7267979 0.816 rs376742 chr20:25487417 A/C cg17903999 chr18:56338584 MALT1 -0.41 -6.81 -0.35 4.6e-11 Liver enzyme levels (alkaline phosphatase); CRC trans rs4263408 0.934 rs9683743 chr4:39703194 A/C cg17169982 chr17:80787973 TBCD;ZNF750 -0.44 -6.72 -0.35 7.98e-11 Plasma amyloid beta peptide concentrations (ABx-40); CRC cis rs7618915 0.501 rs10865974 chr3:52718280 A/C cg15147215 chr3:52552868 STAB1 0.63 10.95 0.52 5.15e-24 Bipolar disorder; CRC cis rs2160860 0.773 rs11773975 chr8:39797690 A/T cg11363097 chr8:39792086 IDO2 -0.42 -7.25 -0.37 2.94e-12 Blood metabolite levels; CRC cis rs11997175 0.713 rs4733454 chr8:33651253 C/A ch.8.33884649F chr8:33765107 NA 0.41 6.32 0.33 8.61e-10 Body mass index; CRC cis rs7618915 0.547 rs12487591 chr3:52642936 A/T cg07507251 chr3:52567010 NT5DC2 0.41 5.96 0.31 6.48e-9 Bipolar disorder; CRC cis rs801193 0.569 rs2707824 chr7:66189243 A/G cg12463550 chr7:65579703 CRCP 0.45 6.15 0.32 2.24e-9 Aortic root size; CRC cis rs11190604 1.000 rs10883493 chr10:102208188 A/T cg07080220 chr10:102295463 HIF1AN 0.47 5.79 0.3 1.63e-8 Palmitoleic acid (16:1n-7) levels; CRC cis rs7618501 1.000 rs60205400 chr3:49800272 C/T cg24308560 chr3:49941425 MST1R -0.47 -7.44 -0.38 9e-13 Intelligence (multi-trait analysis); CRC cis rs7107174 1.000 rs1385601 chr11:77936064 A/C cg02023728 chr11:77925099 USP35 0.51 8.79 0.44 8.69e-17 Testicular germ cell tumor; CRC cis rs72945132 0.882 rs60917762 chr11:70211384 C/T cg00319359 chr11:70116639 PPFIA1 0.55 6.04 0.32 4.16e-9 Coronary artery disease; CRC cis rs2760061 0.819 rs708114 chr1:228197496 G/A cg18477163 chr1:228402036 OBSCN 0.44 7.4 0.38 1.12e-12 Diastolic blood pressure; CRC cis rs4731207 0.564 rs7776821 chr7:124657504 C/T cg23710748 chr7:124431027 NA -0.39 -6.25 -0.33 1.24e-9 Cutaneous malignant melanoma; CRC cis rs4363385 0.747 rs4240868 chr1:152981599 G/A cg25856811 chr1:152973957 SPRR3 -0.25 -6.85 -0.35 3.56e-11 Inflammatory skin disease; CRC cis rs6831352 0.918 rs17218073 chr4:100055739 G/A cg13256891 chr4:100009986 ADH5 -0.66 -8.89 -0.44 4.04e-17 Alcohol dependence; CRC cis rs1865760 0.534 rs1541988 chr6:25950804 C/A cg03264133 chr6:25882463 NA -0.43 -6.48 -0.34 3.26e-10 Height; CRC cis rs4363385 0.818 rs406350 chr1:153007492 C/T cg25856811 chr1:152973957 SPRR3 -0.25 -6.99 -0.36 1.51e-11 Inflammatory skin disease; CRC cis rs4713118 0.527 rs35949862 chr6:28115367 A/G cg12172441 chr6:28176163 NA 0.64 7.53 0.38 5.03e-13 Parkinson's disease; CRC cis rs270601 0.633 rs733300 chr5:131572243 A/G cg18301423 chr5:131593218 PDLIM4 0.46 7.95 0.4 3.01e-14 Acylcarnitine levels; CRC trans rs2303319 0.504 rs62187597 chr2:162398263 A/T cg09481857 chr22:21368659 P2RX6;MGC16703 -0.64 -6.1 -0.32 3.04e-9 Cognitive function; CRC cis rs910316 0.967 rs4899545 chr14:75568138 A/G cg11812906 chr14:75593930 NEK9 0.63 10.18 0.49 2.51e-21 Height; CRC cis rs9916302 0.752 rs12150047 chr17:37601755 A/G cg07936489 chr17:37558343 FBXL20 -0.93 -11.84 -0.55 3.62e-27 Glomerular filtration rate (creatinine); CRC cis rs2625529 0.730 rs2929527 chr15:72282270 T/G cg16672083 chr15:72433130 SENP8 0.47 7.15 0.37 5.83e-12 Red blood cell count; CRC cis rs1552244 0.572 rs58223482 chr3:10169746 G/C cg16606324 chr3:10149918 C3orf24 0.66 7.77 0.39 9.99e-14 Alzheimer's disease; CRC cis rs834811 0.523 rs4732180 chr7:135881462 T/C cg01726295 chr7:135938950 NA 0.34 5.75 0.3 2.07e-8 Post-traumatic stress disorder; CRC cis rs6540559 0.673 rs17015224 chr1:209968918 G/A cg23283495 chr1:209979779 IRF6 0.48 6.82 0.35 4.49e-11 Cleft lip with or without cleft palate; CRC cis rs6545883 0.894 rs12997538 chr2:61564249 A/C cg15711740 chr2:61764176 XPO1 0.48 6.6 0.34 1.69e-10 Tuberculosis; CRC trans rs10982213 0.830 rs2274163 chr9:117188714 C/T cg23721301 chr10:112064230 SMNDC1 0.4 6.37 0.33 6.27e-10 Interleukin-6 levels; CRC trans rs35851103 0.507 rs6601649 chr8:11857317 A/G cg06636001 chr8:8085503 FLJ10661 -0.46 -6.4 -0.33 5.34e-10 Neuroticism; CRC cis rs6951245 1.000 rs75488469 chr7:1102122 A/G cg18402987 chr7:1209562 NA 0.66 7.09 0.36 8.37e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs55665837 1.000 rs12295723 chr11:14450201 T/C cg19336497 chr11:14380999 RRAS2 -0.39 -6.64 -0.34 1.3100000000000001e-10 Vitamin D levels; CRC cis rs10857712 0.754 rs2297033 chr10:135234848 C/T cg19623624 chr10:135278901 LOC619207 -0.35 -5.75 -0.3 2.04e-8 Systemic lupus erythematosus; CRC cis rs7264396 0.887 rs58458373 chr20:34045611 T/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.39 -6.41 -0.33 5.12e-10 Total cholesterol levels; CRC cis rs4713118 0.662 rs149969 chr6:27977737 A/G cg25164649 chr6:28176230 NA 0.66 9.43 0.46 7.69e-19 Parkinson's disease; CRC cis rs10883723 0.810 rs61873733 chr10:104251458 G/A cg04362960 chr10:104952993 NT5C2 -0.43 -6.04 -0.32 4.13e-9 Allergic disease (asthma, hay fever or eczema); CRC cis rs9649213 0.593 rs10953257 chr7:97960664 A/G cg21770322 chr7:97807741 LMTK2 -0.51 -8.39 -0.42 1.5e-15 Prostate cancer (SNP x SNP interaction); CRC cis rs7605827 0.930 rs1318980 chr2:15549890 G/T cg19274914 chr2:15703543 NA 0.38 5.68 0.3 2.91e-8 Educational attainment (years of education); CRC cis rs17767392 0.756 rs11626445 chr14:71739134 C/T cg13720639 chr14:72061746 SIPA1L1 -0.54 -6.58 -0.34 1.8e-10 Mitral valve prolapse; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg00902873 chr3:127771089 SEC61A1 0.4 6.05 0.32 3.87e-9 Intelligence (multi-trait analysis); CRC cis rs9443645 0.901 rs9361488 chr6:79782874 T/C cg05283184 chr6:79620031 NA -0.6 -9.42 -0.46 8.32e-19 Intelligence (multi-trait analysis); CRC cis rs6088580 0.608 rs8114616 chr20:32969092 G/T cg24642439 chr20:33292090 TP53INP2 -0.36 -6.03 -0.32 4.37e-9 Glomerular filtration rate (creatinine); CRC trans rs8035957 1.000 rs4924273 chr15:38846738 C/G cg04999148 chr11:65188955 NEAT1 -0.52 -6.08 -0.32 3.3e-9 Type 1 diabetes; CRC cis rs2549003 0.933 rs7719499 chr5:131814091 C/G cg00255919 chr5:131827918 IRF1 0.58 11.29 0.53 3.32e-25 Asthma (sex interaction); CRC cis rs7552404 1.000 rs437298 chr1:76113770 T/C cg22875332 chr1:76189707 ACADM -0.67 -9.06 -0.45 1.17e-17 Blood metabolite levels;Acylcarnitine levels; CRC trans rs7647973 0.626 rs9830730 chr3:49675875 G/C cg21665057 chr3:196295764 WDR53;FBXO45 -0.67 -7.45 -0.38 8.38e-13 Menarche (age at onset); CRC cis rs8141529 0.748 rs1318026 chr22:29283518 A/G cg15103426 chr22:29168792 CCDC117 0.51 7.1 0.36 7.67e-12 Lymphocyte counts; CRC cis rs7692995 1.000 rs6821168 chr4:18005019 A/C cg08925142 chr4:18023851 LCORL -0.55 -6.06 -0.32 3.73e-9 Height; CRC cis rs651907 0.535 rs17412601 chr3:101499275 T/C cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.59 7.82 0.4 7.47e-14 Colorectal cancer; CRC cis rs6087990 0.806 rs992472 chr20:31385269 G/T cg13636640 chr20:31349939 DNMT3B 0.89 18.21 0.71 9.62e-52 Ulcerative colitis; CRC cis rs13191362 0.935 rs13212137 chr6:163010261 A/G cg23758597 chr6:163146217 PARK2 -0.55 -6.12 -0.32 2.7e-9 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC trans rs10982213 0.830 rs2274163 chr9:117188714 C/T cg16395712 chr17:8339139 NDEL1 0.38 6.08 0.32 3.33e-9 Interleukin-6 levels; CRC cis rs317689 0.702 rs544696 chr12:69749939 T/C cg14784868 chr12:69753453 YEATS4 0.67 9.24 0.45 3.23e-18 Response to diuretic therapy; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg04193309 chr9:139980676 LOC100289341;MAN1B1 0.4 6.18 0.32 1.86e-9 Liver disease severity in Alagille syndrome; CRC cis rs10504229 0.639 rs56066782 chr8:58105857 A/G cg22535103 chr8:58192502 C8orf71 -0.69 -8.8 -0.44 7.79e-17 Developmental language disorder (linguistic errors); CRC cis rs3785574 0.962 rs2597632 chr17:61894739 A/T cg11494091 chr17:61959527 GH2 0.37 5.66 0.3 3.34e-8 Height; CRC cis rs8020095 0.571 rs7156655 chr14:67356061 T/C cg00791868 chr14:66963628 C14orf53 0.5 6.73 0.35 7.73e-11 Depression (quantitative trait); CRC cis rs13082711 0.595 rs6783818 chr3:27361988 C/G cg02860705 chr3:27208620 NA 0.86 11.37 0.53 1.77e-25 Systolic blood pressure;Diastolic blood pressure;Blood pressure; CRC cis rs2882667 0.690 rs288012 chr5:138196273 C/T cg09476006 chr5:138032270 NA -0.56 -10.04 -0.48 7.36e-21 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs9368481 0.761 rs9348746 chr6:26970357 C/G cg05192639 chr6:26864778 GUSBL1 -0.35 -6.05 -0.32 3.97e-9 Autism spectrum disorder or schizophrenia; CRC cis rs6076065 0.723 rs6137924 chr20:23366171 C/G cg11657817 chr20:23433608 CST11 0.45 6.69 0.35 9.76e-11 Facial morphology (factor 15, philtrum width); CRC cis rs7776786 0.934 rs13243526 chr7:18812917 C/T cg13420273 chr7:18810212 HDAC9 -0.33 -6.42 -0.33 4.65e-10 Lobe attachment (rater-scored or self-reported); CRC cis rs1883415 0.591 rs10456305 chr6:24491341 C/T cg20631270 chr6:24437470 GPLD1 -0.41 -6.4 -0.33 5.49e-10 Liver enzyme levels (alkaline phosphatase); CRC cis rs9768139 0.566 rs729099 chr7:158114152 C/T cg06219351 chr7:158114137 PTPRN2 -0.66 -11.21 -0.53 6.23e-25 Calcium levels; CRC cis rs9549367 0.577 rs3024718 chr13:113813853 C/T cg18105134 chr13:113819100 PROZ 0.65 9.4 0.46 9.64e-19 Platelet distribution width; CRC cis rs9399135 0.967 rs9389253 chr6:135329755 T/C cg24558204 chr6:135376177 HBS1L 0.51 8.12 0.41 9.59e-15 Red blood cell count; CRC cis rs12134245 0.719 rs61798831 chr1:91996588 C/T cg21854759 chr1:92012499 NA -0.53 -8.76 -0.43 1.05e-16 Breast cancer; CRC cis rs4308124 0.708 rs7585313 chr2:111975203 A/G cg04571233 chr2:111982156 NA -0.58 -8.46 -0.42 8.83e-16 Vitiligo; CRC trans rs2018683 0.649 rs221193 chr7:29015784 G/T cg19402173 chr7:128379420 CALU -0.45 -6.21 -0.32 1.59e-9 Response to irinotecan and platinum-based chemotherapy in non-small-cell lung cancer; CRC cis rs2415984 0.519 rs2642102 chr14:46965502 A/G cg14871534 chr14:47121158 RPL10L 0.4 5.96 0.31 6.64e-9 Number of children ever born; CRC cis rs208520 1.000 rs208523 chr6:66954195 G/C cg07460842 chr6:66804631 NA -0.92 -11.45 -0.53 8.97e-26 Exhaled nitric oxide output; CRC cis rs1059312 0.771 rs7974764 chr12:129296588 G/C cg23521905 chr12:129298690 SLC15A4;MGC16384 0.38 6.58 0.34 1.85e-10 Systemic lupus erythematosus; CRC cis rs7107174 1.000 rs2511156 chr11:77971167 G/C cg02023728 chr11:77925099 USP35 0.51 7.22 0.37 3.67e-12 Testicular germ cell tumor; CRC cis rs10540 0.908 rs12792111 chr11:520921 G/C cg15790184 chr11:494944 RNH1 0.61 6.25 0.33 1.26e-9 Body mass index; CRC cis rs57994353 1.000 rs57994353 chr9:139356987 T/C cg14119001 chr9:139324193 INPP5E -0.39 -5.85 -0.31 1.21e-8 Eosinophil counts;Cutaneous squamous cell carcinoma; CRC cis rs7914558 0.966 rs10786721 chr10:104654383 C/A cg15744005 chr10:104629667 AS3MT -0.33 -7.19 -0.37 4.36e-12 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC trans rs61931739 0.517 rs1843735 chr12:34047389 C/G cg26384229 chr12:38710491 ALG10B 0.48 6.57 0.34 1.92e-10 Morning vs. evening chronotype; CRC cis rs514406 0.644 rs7552663 chr1:53204352 C/T cg27535305 chr1:53392650 SCP2 0.34 6.36 0.33 6.57e-10 Monocyte count; CRC cis rs11229555 0.645 rs11229489 chr11:58244917 A/G cg15696309 chr11:58395628 NA -0.9 -11.63 -0.54 1.95e-26 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; CRC cis rs473651 0.935 rs558924 chr2:239339511 A/G cg21699342 chr2:239360505 ASB1 0.52 8.17 0.41 6.67e-15 Multiple system atrophy; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg03395546 chr19:41222599 ADCK4;ITPKC 0.45 7.0 0.36 1.45e-11 Liver disease severity in Alagille syndrome; CRC cis rs3026101 0.671 rs14231 chr17:5294976 T/A cg25236894 chr17:5323110 RPAIN;NUP88 0.42 6.84 0.35 3.98e-11 Body mass index; CRC cis rs7705042 0.865 rs6874308 chr5:141506911 C/T cg08523384 chr5:141488047 NDFIP1 -0.33 -5.84 -0.31 1.23e-8 Asthma; CRC cis rs6908034 0.607 rs73376650 chr6:19805506 T/G cg02682789 chr6:19804855 NA 0.8 6.74 0.35 6.9e-11 Endometriosis;Deep ovarian and/or rectovaginal disease with dense adhesions; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg18247638 chr13:103451366 KDELC1;BIVM 0.5 7.39 0.38 1.21e-12 Intelligence (multi-trait analysis); CRC cis rs2072499 1.000 rs2241108 chr1:156181007 C/G cg25208724 chr1:156163844 SLC25A44 1.08 26.22 0.82 1.39e-82 Testicular germ cell tumor; CRC cis rs8177253 1.000 rs8177247 chr3:133479499 T/G cg11941060 chr3:133502564 NA -0.59 -10.45 -0.5 2.9e-22 Iron status biomarkers; CRC cis rs13118159 0.836 rs2276903 chr4:1343405 A/G cg20092199 chr4:1342459 KIAA1530 0.46 8.28 0.42 3.11e-15 Longevity; CRC cis rs9911578 0.900 rs8067264 chr17:57182793 G/C cg12560992 chr17:57184187 TRIM37 0.95 18.2 0.71 1.07e-51 Intelligence (multi-trait analysis); CRC cis rs57221529 0.766 rs72703065 chr5:588123 C/A cg09021430 chr5:549028 NA -0.72 -7.85 -0.4 5.75e-14 Lung disease severity in cystic fibrosis; CRC cis rs7209700 0.889 rs11079769 chr17:45349731 A/T cg08085267 chr17:45401833 C17orf57 0.46 6.67 0.35 1.1e-10 IgG glycosylation; CRC cis rs11792861 0.926 rs11788825 chr9:111829757 T/G cg05043794 chr9:111880884 C9orf5 -0.35 -6.7 -0.35 8.83e-11 Menarche (age at onset); CRC cis rs7552404 1.000 rs7548962 chr1:76139266 G/A cg03433033 chr1:76189801 ACADM 0.81 11.29 0.53 3.35e-25 Blood metabolite levels;Acylcarnitine levels; CRC cis rs2404602 0.583 rs12907668 chr15:76589767 A/T cg26408565 chr15:76604113 ETFA -0.36 -5.71 -0.3 2.48e-8 Blood metabolite levels; CRC cis rs11098499 0.954 rs6848389 chr4:120402622 A/G cg09307838 chr4:120376055 NA 0.72 11.14 0.52 1.14e-24 Corneal astigmatism; CRC trans rs1005277 0.579 rs9418322 chr10:38377296 G/T cg23533926 chr12:111358616 MYL2 -0.52 -7.82 -0.4 7.26e-14 Extrinsic epigenetic age acceleration; CRC cis rs897984 0.683 rs8050330 chr16:30824970 C/T cg02466173 chr16:30829666 NA -0.9 -16.61 -0.68 2.07e-45 Dementia with Lewy bodies; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg04248937 chr5:1222847 SLC6A19 0.43 6.31 0.33 9.02e-10 Liver disease severity in Alagille syndrome; CRC cis rs1129187 0.720 rs9471972 chr6:42915021 G/A cg27588902 chr6:42928151 GNMT -0.38 -6.85 -0.35 3.7e-11 Alzheimer's disease in APOE e4+ carriers; CRC cis rs4664293 0.867 rs13415100 chr2:160586227 G/A cg08347373 chr2:160653686 CD302 -0.47 -7.43 -0.38 9.32e-13 Monocyte percentage of white cells; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg07139811 chr2:176033051 ATF2;MIR933 0.4 6.33 0.33 8e-10 Liver disease severity in Alagille syndrome; CRC cis rs4363385 0.747 rs10399896 chr1:152975083 T/A cg25856811 chr1:152973957 SPRR3 -0.26 -7.23 -0.37 3.42e-12 Inflammatory skin disease; CRC cis rs6815814 0.861 rs10034903 chr4:38784678 C/G cg06935464 chr4:38784597 TLR10 0.63 8.27 0.41 3.43e-15 Breast cancer; CRC cis rs12545109 0.917 rs1370304 chr8:57322822 G/C cg09654669 chr8:57350985 NA -0.46 -7.18 -0.37 4.7e-12 Obesity-related traits; CRC cis rs6088580 0.634 rs6059878 chr20:33087166 A/T cg24642439 chr20:33292090 TP53INP2 0.39 6.59 0.34 1.73e-10 Glomerular filtration rate (creatinine); CRC cis rs7429990 0.965 rs4392441 chr3:48077701 C/T cg11946769 chr3:48343235 NME6 -0.45 -5.82 -0.31 1.42e-8 Educational attainment (years of education); CRC cis rs2070997 0.756 rs7872328 chr9:133727453 T/A cg01000188 chr9:133769184 QRFP 0.5 5.92 0.31 8.28e-9 Response to amphetamines; CRC cis rs7932354 0.528 rs10769234 chr11:47084061 G/C cg19486271 chr11:47235900 DDB2 -0.45 -6.46 -0.34 3.8e-10 Bone mineral density (hip);Bone mineral density; CRC cis rs6835098 0.924 rs7672108 chr4:174165126 A/G cg08422745 chr4:174089978 GALNT7 0.88 14.32 0.62 1.81e-36 Dementia and core Alzheimer's disease neuropathologic changes; CRC trans rs11098499 0.909 rs71614422 chr4:120359340 G/A cg25214090 chr10:38739885 LOC399744 0.66 10.51 0.5 1.88e-22 Corneal astigmatism; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg22727364 chr8:126443014 TRIB1 0.39 6.13 0.32 2.57e-9 Intelligence (multi-trait analysis); CRC cis rs1178968 0.901 rs2353066 chr7:72755791 T/G cg25889504 chr7:72793014 NA 0.51 5.82 0.31 1.37e-8 Triglyceride levels; CRC trans rs7395662 0.963 rs9666932 chr11:48726240 G/A cg21153622 chr11:89784906 NA 0.46 7.41 0.38 1.06e-12 HDL cholesterol; CRC cis rs6942756 0.774 rs2402944 chr7:128951402 G/T cg02491457 chr7:128862824 NA -0.63 -8.86 -0.44 5.27e-17 White matter hyperintensity burden; CRC cis rs9443189 0.615 rs618239 chr6:76350038 A/G cg01950844 chr6:76311363 SENP6 0.73 9.76 0.47 6.14e-20 Prostate cancer; CRC cis rs10256972 0.681 rs6979076 chr7:1116247 C/T cg03188948 chr7:1209495 NA -0.45 -6.48 -0.34 3.25e-10 Longevity;Endometriosis; CRC cis rs4713118 0.869 rs6902689 chr6:27709441 C/T cg02683197 chr6:28174875 NA 0.62 8.36 0.42 1.78e-15 Parkinson's disease; CRC cis rs898097 0.544 rs6502022 chr17:80908652 C/T cg19046167 chr17:80928561 B3GNTL1 0.48 8.11 0.41 1.01e-14 Breast cancer; CRC cis rs10504229 0.593 rs1442127 chr8:57992136 T/C cg21724239 chr8:58056113 NA 0.56 7.26 0.37 2.79e-12 Developmental language disorder (linguistic errors); CRC cis rs7726839 0.574 rs12517345 chr5:628294 G/A cg09021430 chr5:549028 NA -0.73 -8.37 -0.42 1.66e-15 Obesity-related traits; CRC cis rs7605827 0.930 rs765432 chr2:15561440 C/T cg19274914 chr2:15703543 NA -0.42 -6.33 -0.33 7.8e-10 Educational attainment (years of education); CRC cis rs4285028 0.699 rs1920297 chr3:121598000 T/C cg11130432 chr3:121712080 ILDR1 -0.5 -6.14 -0.32 2.33e-9 Multiple sclerosis; CRC cis rs72772090 0.539 rs72773981 chr5:96156059 A/C cg17330273 chr5:96107758 CAST;ERAP1 -0.58 -5.68 -0.3 2.94e-8 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs875971 0.862 rs6460302 chr7:65960257 C/G cg18252515 chr7:66147081 NA -0.42 -6.1 -0.32 2.99e-9 Aortic root size; CRC cis rs11098499 0.863 rs7678400 chr4:120461957 G/A cg24375607 chr4:120327624 NA 0.48 7.43 0.38 9.4e-13 Corneal astigmatism; CRC cis rs2239547 0.522 rs6771610 chr3:53026104 T/C cg18404041 chr3:52824283 ITIH1 -0.4 -7.66 -0.39 2.11e-13 Schizophrenia; CRC cis rs2404602 0.692 rs58361452 chr15:76973372 T/C cg03037974 chr15:76606532 NA 0.7 12.45 0.57 2.07e-29 Blood metabolite levels; CRC cis rs9905704 0.627 rs1267544 chr17:56643398 T/G cg12560992 chr17:57184187 TRIM37 -0.51 -6.03 -0.32 4.46e-9 Testicular germ cell tumor; CRC cis rs11958404 0.932 rs72816598 chr5:157436017 G/A cg05962755 chr5:157440814 NA 0.95 12.36 0.56 4.48e-29 IgG glycosylation; CRC cis rs754466 0.580 rs1054608 chr10:79543308 T/G cg17075019 chr10:79541650 NA -0.99 -19.73 -0.74 9.59e-58 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs6860806 0.695 rs11952099 chr5:131576772 A/G cg12564285 chr5:131593104 PDLIM4 0.5 9.72 0.47 8.35e-20 Breast cancer; CRC cis rs356992 0.915 rs356977 chr2:60748758 A/G cg08426369 chr2:60753602 BCL11A 0.52 7.09 0.36 8.1e-12 Educational attainment (years of education); CRC cis rs9522267 0.535 rs9522303 chr13:112237301 T/C cg26182253 chr13:112236782 NA 0.31 6.23 0.32 1.4e-9 Hepatitis; CRC cis rs9399135 0.967 rs9376075 chr6:135296963 A/G cg22676075 chr6:135203613 NA 0.43 6.69 0.35 9.9e-11 Red blood cell count; CRC cis rs12692738 0.526 rs355831 chr2:165616757 C/A cg03182029 chr2:165697222 COBLL1 0.48 5.66 0.3 3.32e-8 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);Waist-to-hip ratio adjusted for BMI in non-smokers;Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction);Waist-to-hip ratio adjusted for body mass index; CRC cis rs34779708 0.966 rs35146199 chr10:35460939 T/C cg03585969 chr10:35415529 CREM 0.65 8.58 0.43 3.84e-16 Inflammatory bowel disease;Crohn's disease; CRC trans rs2228479 0.850 rs2239358 chr16:89827330 C/G cg24644049 chr4:85504048 CDS1 0.86 6.93 0.36 2.29e-11 Skin colour saturation; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg05518842 chr16:1823291 MRPS34;EME2 0.42 7.75 0.39 1.12e-13 Liver disease severity in Alagille syndrome; CRC cis rs9549260 0.816 rs964901 chr13:41248698 C/T cg21288729 chr13:41239152 FOXO1 0.5 7.75 0.39 1.13e-13 Red blood cell count; CRC cis rs7737355 0.947 rs193458 chr5:130816284 G/C cg06307176 chr5:131281290 NA 0.42 6.37 0.33 6.44e-10 Life satisfaction; CRC cis rs910316 0.763 rs175490 chr14:75545685 A/G cg11812906 chr14:75593930 NEK9 0.59 9.2 0.45 4.36e-18 Height; CRC cis rs9457247 0.508 rs7760495 chr6:167506795 C/T cg07513332 chr6:167530253 CCR6 0.34 6.0 0.31 5.15e-9 Crohn's disease; CRC cis rs7615952 0.736 rs9862893 chr3:125686974 A/G cg05084668 chr3:125655381 ALG1L -0.88 -12.77 -0.58 1.29e-30 Blood pressure (smoking interaction); CRC cis rs60871478 1.000 rs60871478 chr7:827325 A/G cg05535760 chr7:792225 HEATR2 0.81 10.86 0.51 1.08e-23 Cerebrospinal P-tau181p levels; CRC cis rs7429990 0.931 rs62262084 chr3:47653822 C/T cg11946769 chr3:48343235 NME6 0.5 5.7 0.3 2.67e-8 Educational attainment (years of education); CRC cis rs7412746 0.634 rs3754212 chr1:150738200 A/G cg17724175 chr1:150552817 MCL1 0.49 7.3 0.37 2.19e-12 Melanoma; CRC cis rs7044106 0.734 rs1981020 chr9:123388464 C/T cg14255062 chr9:123606675 PSMD5;LOC253039 0.46 7.08 0.36 8.68e-12 Hip circumference adjusted for BMI; CRC cis rs12681288 0.676 rs2701923 chr8:994605 A/G cg08648136 chr8:956695 NA 0.3 5.77 0.3 1.85e-8 Schizophrenia; CRC cis rs9910055 0.960 rs9911991 chr17:42278916 G/C cg09913183 chr17:42254507 C17orf65;ASB16 0.57 8.03 0.4 1.72e-14 Total body bone mineral density; CRC cis rs9611565 0.729 rs203320 chr22:41913477 T/C cg06634786 chr22:41940651 POLR3H -0.42 -5.71 -0.3 2.54e-8 Vitiligo; CRC cis rs6456156 0.586 rs12527827 chr6:167469271 C/T cg07741184 chr6:167504864 NA 0.39 6.85 0.35 3.66e-11 Primary biliary cholangitis; CRC cis rs763121 0.853 rs4821798 chr22:39021165 T/C cg06544989 chr22:39130855 UNC84B 0.46 7.44 0.38 8.69e-13 Menopause (age at onset); CRC cis rs8008758 0.517 rs1772024 chr14:101695220 A/C cg26224664 chr14:101693935 NA 0.5 8.93 0.44 2.97e-17 Body mass index (alcohol intake interaction); CRC cis rs6964587 0.692 rs4727268 chr7:91840724 T/C cg17063962 chr7:91808500 NA 0.64 10.43 0.5 3.48e-22 Breast cancer; CRC cis rs4700695 0.841 rs251608 chr5:65247893 C/T cg21114390 chr5:65439923 SFRS12 0.5 6.21 0.32 1.57e-9 Facial morphology (factor 19); CRC cis rs3764400 0.567 rs8079616 chr17:46213488 C/T cg10706073 chr17:46328419 SKAP1 0.62 6.52 0.34 2.7e-10 Body mass index; CRC cis rs7809950 1.000 rs28714607 chr7:107106253 T/C cg23024343 chr7:107201750 COG5 -0.61 -8.71 -0.43 1.54e-16 Coronary artery disease; CRC cis rs8078723 0.901 rs709591 chr17:38175561 T/A cg17467752 chr17:38218738 THRA 0.74 12.1 0.55 3.95e-28 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg04579211 chr15:41221939 DLL4 0.49 7.08 0.36 8.81e-12 Response to antipsychotic treatment; CRC cis rs9534288 0.913 rs9534298 chr13:46625566 C/G cg15192986 chr13:46630673 CPB2 -0.74 -10.26 -0.49 1.32e-21 Blood protein levels; CRC cis rs7259376 0.875 rs4932755 chr19:22494816 A/G cg02657401 chr19:22469223 NA -0.36 -7.96 -0.4 2.85e-14 Menopause (age at onset); CRC cis rs7131987 0.903 rs2194518 chr12:29419460 C/T cg09582351 chr12:29534625 ERGIC2 -0.33 -6.97 -0.36 1.78e-11 QT interval; CRC cis rs12760731 0.565 rs12406779 chr1:178088936 C/G cg00404053 chr1:178313656 RASAL2 1.06 11.28 0.53 3.63e-25 Obesity-related traits; CRC cis rs2786111 0.965 rs1764622 chr1:197282079 T/C cg13682187 chr1:196946512 CFHR5 0.29 5.71 0.3 2.47e-8 Lupus nephritis in systemic lupus erythematosus; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg23868848 chr8:128806661 PVT1 -0.39 -6.17 -0.32 1.98e-9 Myopia (pathological); CRC cis rs9916302 0.904 rs4795356 chr17:37535631 C/T cg03013999 chr17:37608204 MED1 -0.47 -7.35 -0.38 1.61e-12 Glomerular filtration rate (creatinine); CRC cis rs2290159 0.800 rs11128607 chr3:12673275 A/G cg23032965 chr3:12705835 RAF1 0.47 6.38 0.33 6.16e-10 Cholesterol, total; CRC cis rs2635047 0.566 rs8092050 chr18:44796323 C/T cg19077165 chr18:44547161 KATNAL2 -0.39 -5.95 -0.31 6.9e-9 Educational attainment; CRC cis rs172166 0.637 rs1225592 chr6:28150242 G/A cg15786705 chr6:28176104 NA 0.68 10.18 0.49 2.51e-21 Cardiac Troponin-T levels; CRC cis rs172166 0.561 rs149974 chr6:27985096 T/C cg06470822 chr6:28175283 NA 0.65 9.68 0.47 1.16e-19 Cardiac Troponin-T levels; CRC cis rs35306767 0.761 rs11253537 chr10:1010735 G/A cg26597838 chr10:835615 NA 0.94 11.01 0.52 3.17e-24 Eosinophil percentage of granulocytes; CRC cis rs7618915 0.571 rs17264436 chr3:52610651 T/A cg18404041 chr3:52824283 ITIH1 -0.43 -8.97 -0.44 2.23e-17 Bipolar disorder; CRC cis rs9807989 0.801 rs72823663 chr2:102968738 G/C cg03938978 chr2:103052716 IL18RAP 0.36 5.92 0.31 7.92e-9 Asthma; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg24350612 chr8:73921026 TERF1 0.42 5.97 0.31 6.08e-9 Anxiety disorder; CRC cis rs294883 0.701 rs2007263 chr6:159735074 G/A cg14500486 chr6:159655392 FNDC1 -0.36 -5.87 -0.31 1.08e-8 Coronary artery disease; CRC cis rs56114371 0.568 rs200468 chr6:27757855 C/G cg02683197 chr6:28174875 NA 0.52 6.04 0.32 4.06e-9 Breast cancer; CRC cis rs554111 0.637 rs529162 chr1:21063311 T/A cg02927042 chr1:21476669 EIF4G3 -0.37 -5.62 -0.3 3.98e-8 Facial morphology (factor 17, height of vermillion upper lip); CRC cis rs17376456 0.825 rs28645862 chr5:93233128 G/C cg21475434 chr5:93447410 FAM172A 0.78 7.82 0.4 7.47e-14 Diabetic retinopathy; CRC cis rs6831352 0.879 rs29001208 chr4:100052539 A/C cg13256891 chr4:100009986 ADH5 -0.65 -8.7 -0.43 1.57e-16 Alcohol dependence; CRC cis rs9911578 0.904 rs7209253 chr17:56908987 C/T cg12560992 chr17:57184187 TRIM37 0.92 16.91 0.68 1.29e-46 Intelligence (multi-trait analysis); CRC cis rs6952808 1.000 rs6978048 chr7:1886872 T/G cg04267008 chr7:1944627 MAD1L1 -0.76 -10.84 -0.51 1.32e-23 Bipolar disorder and schizophrenia; CRC cis rs6089584 0.546 rs6061978 chr20:60615604 C/T cg23262073 chr20:60523788 NA -0.37 -5.83 -0.31 1.31e-8 Body mass index; CRC cis rs12908161 0.959 rs34028043 chr15:85231585 G/A cg11189052 chr15:85197271 WDR73 0.62 8.86 0.44 4.93e-17 Schizophrenia; CRC cis rs7119 0.689 rs12916833 chr15:77819778 G/A cg27398640 chr15:77910606 LINGO1 -0.43 -7.44 -0.38 9.03e-13 Type 2 diabetes; CRC cis rs13118159 0.509 rs10023473 chr4:1375285 C/T cg16405210 chr4:1374714 KIAA1530 -0.94 -15.49 -0.65 4.94e-41 Longevity; CRC cis rs10504229 0.639 rs66667899 chr8:58117065 C/T cg22535103 chr8:58192502 C8orf71 -0.7 -9.34 -0.46 1.47e-18 Developmental language disorder (linguistic errors); CRC cis rs9660992 0.573 rs12126439 chr1:205200720 C/T cg03948781 chr1:205179583 DSTYK 0.41 5.62 0.3 4.02e-8 Mean corpuscular volume;Mean platelet volume; CRC cis rs34172651 0.517 rs36113933 chr16:24838862 A/G cg02428538 chr16:24856791 SLC5A11 -0.54 -6.4 -0.33 5.49e-10 Intelligence (multi-trait analysis); CRC trans rs2303319 0.504 rs12470743 chr2:162611202 G/A cg14875682 chr5:52083620 ITGA1;PELO -0.73 -6.16 -0.32 2.11e-9 Cognitive function; CRC cis rs2228479 0.850 rs2286393 chr16:89809548 C/A cg06656553 chr16:89960601 TCF25 -0.69 -5.73 -0.3 2.33e-8 Skin colour saturation; CRC cis rs17401966 0.838 rs1013953 chr1:10319459 T/A cg19773385 chr1:10388646 KIF1B -0.67 -11.11 -0.52 1.46e-24 Hepatocellular carcinoma; CRC cis rs57221529 0.709 rs72706612 chr5:561198 C/T cg09021430 chr5:549028 NA -0.72 -8.15 -0.41 7.73e-15 Lung disease severity in cystic fibrosis; CRC cis rs13191362 0.507 rs6936804 chr6:163069424 A/T cg06582575 chr6:163149167 PACRG;PARK2 -0.56 -8.39 -0.42 1.41e-15 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs2153535 0.580 rs6913100 chr6:8456855 A/G cg07606381 chr6:8435919 SLC35B3 0.68 11.1 0.52 1.62e-24 Motion sickness; CRC trans rs2303319 0.504 rs62189054 chr2:162624654 C/G cg27342122 chr8:133787442 PHF20L1 -0.72 -6.09 -0.32 3.2e-9 Cognitive function; CRC cis rs4555082 0.874 rs2142190 chr14:105719306 G/A cg18132624 chr14:105716052 BTBD6;BRF1 -0.51 -8.2 -0.41 5.49e-15 Mean platelet volume;Platelet distribution width; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg00448143 chr16:56703788 MT1H 0.36 6.21 0.32 1.59e-9 Liver disease severity in Alagille syndrome; CRC cis rs7726839 0.561 rs72703050 chr5:582917 A/C cg16447950 chr5:562315 NA -0.84 -12.37 -0.56 4.19e-29 Obesity-related traits; CRC cis rs9911578 0.967 rs405684 chr17:56777148 T/C cg12560992 chr17:57184187 TRIM37 0.9 16.37 0.67 1.74e-44 Intelligence (multi-trait analysis); CRC cis rs7772486 0.720 rs9403757 chr6:146261271 C/T cg23711669 chr6:146136114 FBXO30 -0.71 -12.51 -0.57 1.25e-29 Lobe attachment (rater-scored or self-reported); CRC trans rs10842750 1.000 rs10842750 chr12:26690565 G/T cg08924777 chr16:48278166 LONP2 0.52 5.99 0.31 5.58e-9 Kashin-Beck disease; CRC cis rs3751196 0.803 rs12422701 chr12:104185661 A/G cg02344784 chr12:104178138 NT5DC3 0.71 7.25 0.37 2.92e-12 Sense of smell; CRC cis rs2239547 0.603 rs6789219 chr3:53098938 C/G cg11645453 chr3:52864694 ITIH4 0.53 8.82 0.44 6.94e-17 Schizophrenia; CRC cis rs853679 0.517 rs6922063 chr6:28094366 G/A cg23161317 chr6:28129485 ZNF389 0.53 6.64 0.34 1.29e-10 Depression; CRC trans rs61931739 0.500 rs11053235 chr12:34507899 G/A cg26384229 chr12:38710491 ALG10B 0.67 8.88 0.44 4.28e-17 Morning vs. evening chronotype; CRC cis rs7914558 0.966 rs11191438 chr10:104637864 C/G cg04362960 chr10:104952993 NT5C2 0.6 9.24 0.45 3.17e-18 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs2836974 0.897 rs8132295 chr21:40527774 A/G cg06238570 chr21:40685208 BRWD1 -0.7 -9.95 -0.48 1.42e-20 Cognitive function; CRC cis rs1552244 0.751 rs12715665 chr3:10021601 C/T cg13047869 chr3:10149882 C3orf24 0.48 6.78 0.35 5.47e-11 Alzheimer's disease; CRC cis rs6502050 0.835 rs4789737 chr17:80123269 G/A cg09264619 chr17:80180166 NA -0.35 -5.93 -0.31 7.47e-9 Life satisfaction; CRC trans rs11039798 0.920 rs116109043 chr11:48976940 C/T cg03929089 chr4:120376271 NA 0.64 6.1 0.32 2.95e-9 Axial length; CRC cis rs1348850 0.632 rs12616288 chr2:178503813 G/T cg22681709 chr2:178499509 PDE11A -0.51 -9.48 -0.46 5.06e-19 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs10504229 1.000 rs3814486 chr8:58191226 A/T cg22535103 chr8:58192502 C8orf71 -0.82 -12.27 -0.56 9.63e-29 Developmental language disorder (linguistic errors); CRC cis rs1707322 1.000 rs7517560 chr1:46425943 A/G cg03146154 chr1:46216737 IPP 0.51 7.12 0.37 6.96e-12 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg04385144 chr22:27053419 MIAT 0.34 6.0 0.31 5.25e-9 Liver disease severity in Alagille syndrome; CRC cis rs9926296 0.528 rs4785721 chr16:89839997 G/A cg21285383 chr16:89894308 SPIRE2 0.37 6.21 0.32 1.62e-9 Vitiligo; CRC cis rs10206020 0.921 rs72778009 chr2:1573322 G/T cg26248373 chr2:1572462 NA -0.86 -12.69 -0.57 2.63e-30 IgG glycosylation; CRC cis rs800160 0.668 rs10734191 chr11:2341002 C/T cg09785033 chr11:2336066 TSPAN32 -0.48 -5.61 -0.3 4.3e-8 Bacteremia; CRC cis rs1008375 0.898 rs7670500 chr4:17586957 A/G cg16339924 chr4:17578868 LAP3 0.6 7.98 0.4 2.42e-14 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs62458065 0.640 rs6950077 chr7:32502895 A/G cg20159608 chr7:32802032 NA 0.56 7.42 0.38 1e-12 Metabolite levels (HVA/MHPG ratio); CRC cis rs2463822 0.844 rs2513737 chr11:62119495 G/C cg06239285 chr11:62104954 ASRGL1 0.95 10.93 0.52 6.22e-24 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs826838 0.935 rs1719855 chr12:39127242 C/T cg26384229 chr12:38710491 ALG10B -0.64 -9.58 -0.47 2.56e-19 Heart rate; CRC cis rs6681460 1.000 rs1445575 chr1:67052164 C/T cg02459107 chr1:67143332 SGIP1 0.48 8.17 0.41 6.69e-15 Presence of antiphospholipid antibodies; CRC cis rs7772486 0.875 rs10457792 chr6:146412415 T/C cg23711669 chr6:146136114 FBXO30 0.66 11.41 0.53 1.27e-25 Lobe attachment (rater-scored or self-reported); CRC trans rs9858542 0.953 rs1873625 chr3:49666964 C/A cg21665057 chr3:196295764 WDR53;FBXO45 -0.69 -8.95 -0.44 2.61e-17 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs881375 0.967 rs7039505 chr9:123705945 A/T cg09419670 chr9:123605666 PSMD5;LOC253039 0.56 8.34 0.42 2.09e-15 Rheumatoid arthritis; CRC cis rs4589502 1.000 rs16950284 chr15:67154184 A/G cg09911534 chr15:67153556 NA 0.53 5.7 0.3 2.69e-8 Lung cancer (smoking interaction); CRC cis rs875971 1.000 rs1167612 chr7:65567976 C/A cg12463550 chr7:65579703 CRCP -0.49 -7.07 -0.36 9.17e-12 Aortic root size; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg24580635 chr7:76178542 LOC100133091 0.4 6.32 0.33 8.56e-10 Liver disease severity in Alagille syndrome; CRC cis rs4481887 0.676 rs946764 chr1:248522033 A/C cg00666640 chr1:248458726 OR2T12 0.35 6.62 0.34 1.49e-10 Common traits (Other); CRC trans rs9929218 1.000 rs67359183 chr16:68814204 T/C cg04657470 chr2:198365150 HSPE1;HSPD1 -0.83 -11.85 -0.55 3.21e-27 Colorectal cancer; CRC cis rs4332037 0.506 rs62442924 chr7:1989976 C/T cg25834613 chr7:1915315 MAD1L1 -0.42 -6.04 -0.32 4.24e-9 Bipolar disorder; CRC cis rs1348850 0.519 rs1527406 chr2:178525655 C/T cg02961200 chr2:178257176 LOC100130691;AGPS 0.52 7.2 0.37 4.19e-12 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs9457247 1.000 rs408040 chr6:167398903 A/T cg23791538 chr6:167370224 RNASET2 -0.38 -5.94 -0.31 7.32e-9 Crohn's disease; CRC cis rs853679 0.542 rs9393892 chr6:28081394 A/G cg06470822 chr6:28175283 NA 0.99 13.01 0.58 1.7e-31 Depression; CRC cis rs35146811 0.695 rs1618851 chr7:99810643 T/G cg13334819 chr7:99746414 C7orf59 0.51 6.71 0.35 8.67e-11 Coronary artery disease; CRC cis rs2032447 0.966 rs9358901 chr6:26024436 G/T cg04800585 chr6:26043546 HIST1H2BB 0.54 8.29 0.42 2.96e-15 Intelligence (multi-trait analysis); CRC cis rs736408 0.812 rs2270197 chr3:52824095 T/G cg18099408 chr3:52552593 STAB1 -0.39 -5.72 -0.3 2.44e-8 Bipolar disorder; CRC cis rs2737618 0.722 rs2821330 chr1:200082464 C/T cg21825944 chr1:200113062 NR5A2 0.47 6.48 0.34 3.26e-10 Uric acid levels; CRC cis rs780096 0.506 rs2303369 chr2:27715416 C/T cg24768116 chr2:27665128 KRTCAP3 -0.35 -7.66 -0.39 2.03e-13 Total body bone mineral density; CRC trans rs6561151 0.681 rs17571812 chr13:44472462 G/A cg12856521 chr11:46389249 DGKZ 0.81 9.93 0.48 1.73e-20 Crohn's disease; CRC cis rs911555 0.547 rs8006994 chr14:103841296 C/T cg12935359 chr14:103987150 CKB -0.51 -8.02 -0.4 1.84e-14 Intelligence (multi-trait analysis); CRC cis rs7647973 1.000 rs13096474 chr3:49443081 C/T cg20833759 chr3:49053208 WDR6;DALRD3 -0.52 -8.04 -0.41 1.58e-14 Menarche (age at onset); CRC cis rs1712517 0.525 rs11191642 chr10:105055912 A/G cg04362960 chr10:104952993 NT5C2 -0.47 -6.15 -0.32 2.29e-9 Migraine; CRC cis rs4713118 0.616 rs9348789 chr6:28025486 C/T cg21251018 chr6:28226885 NKAPL 0.46 6.46 0.34 3.67e-10 Parkinson's disease; CRC cis rs3760982 0.935 rs10422990 chr19:44295273 C/T cg12072164 chr19:44306565 LYPD5 0.39 6.14 0.32 2.36e-9 Breast cancer (estrogen-receptor negative);Breast cancer; CRC cis rs8018967 0.622 rs2041073 chr14:73972535 C/T cg08936952 chr14:74026160 HEATR4 -0.38 -5.6 -0.3 4.49e-8 Blood metabolite ratios; CRC cis rs3806843 0.548 rs246055 chr5:140325662 C/T cg19875535 chr5:140030758 IK 0.39 6.02 0.31 4.67e-9 Depressive symptoms (multi-trait analysis); CRC cis rs681343 1.000 rs492602 chr19:49206417 A/G cg21064579 chr19:49206444 FUT2 0.51 9.18 0.45 4.87e-18 Lung adenocarcinoma;Primary sclerosing cholangitis;Childhood ear infection; CRC cis rs9517320 1.000 rs7996093 chr13:99133092 T/C cg20487152 chr13:99095054 FARP1 0.35 5.63 0.3 3.95e-8 Longevity; CRC cis rs16975963 0.843 rs75802547 chr19:38393321 C/T cg15135657 chr19:38346511 NA -0.44 -5.88 -0.31 9.82e-9 Longevity; CRC trans rs7615952 0.576 rs17523380 chr3:125802874 C/T cg07211511 chr3:129823064 LOC729375 -0.44 -6.06 -0.32 3.68e-9 Blood pressure (smoking interaction); CRC cis rs2625529 0.590 rs8023703 chr15:72504059 G/A cg16672083 chr15:72433130 SENP8 0.39 5.65 0.3 3.46e-8 Red blood cell count; CRC trans rs7647973 0.626 rs1352889 chr3:49652148 T/C cg21665057 chr3:196295764 WDR53;FBXO45 -0.66 -7.42 -0.38 1.03e-12 Menarche (age at onset); CRC cis rs875971 1.000 rs6958271 chr7:65979331 A/C cg00343986 chr7:65444356 GUSB 0.44 6.46 0.34 3.84e-10 Aortic root size; CRC cis rs2075371 0.579 rs11766422 chr7:134018160 T/C cg20476274 chr7:133979776 SLC35B4 0.53 7.72 0.39 1.38e-13 Mean platelet volume; CRC cis rs877282 0.755 rs2790388 chr10:786084 T/C cg17470449 chr10:769945 NA 0.46 6.35 0.33 7.26e-10 Uric acid levels; CRC cis rs853679 0.882 rs9461432 chr6:28086883 T/C cg03623178 chr6:28175578 NA 0.83 6.72 0.35 7.91e-11 Depression; CRC cis rs4285028 0.948 rs12488851 chr3:121687192 C/T cg11130432 chr3:121712080 ILDR1 -0.52 -6.75 -0.35 6.81e-11 Multiple sclerosis; CRC cis rs2180341 0.960 rs3756996 chr6:127664258 G/C cg24812749 chr6:127587940 RNF146 0.96 13.36 0.59 7.92e-33 Breast cancer; CRC cis rs644799 0.965 rs602512 chr11:95561682 G/A cg03916912 chr11:95522834 CEP57;FAM76B 0.95 18.26 0.71 6.46e-52 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs12024301 0.557 rs6668853 chr1:183608040 T/C cg11505048 chr1:183622726 RGL1;APOBEC4 0.77 6.73 0.35 7.45e-11 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs7727544 0.507 rs10051679 chr5:131570931 T/A cg01305625 chr5:131593812 PDLIM4 0.32 5.65 0.3 3.47e-8 Blood metabolite levels; CRC cis rs7772486 0.875 rs2777483 chr6:146329235 A/G cg23711669 chr6:146136114 FBXO30 0.62 10.4 0.5 4.48e-22 Lobe attachment (rater-scored or self-reported); CRC cis rs7614311 0.636 rs73117047 chr3:63910779 G/A cg22134162 chr3:63841271 THOC7 -0.58 -5.84 -0.31 1.27e-8 Lung function (FVC);Lung function (FEV1); CRC cis rs9611565 0.694 rs79008 chr22:41850500 C/T cg03806693 chr22:41940476 POLR3H -0.91 -12.41 -0.56 2.95e-29 Vitiligo; CRC cis rs13144136 0.748 rs4697774 chr4:10670461 A/G cg10242279 chr4:10666415 CLNK -0.33 -5.64 -0.3 3.74e-8 Resistance to antihypertensive treatment in hypertension; CRC cis rs7811142 0.943 rs73403312 chr7:100024153 T/C cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.18 17.67 0.7 1.31e-49 Platelet count; CRC cis rs9611565 0.559 rs132761 chr22:42004371 C/T cg03806693 chr22:41940476 POLR3H 1.05 12.34 0.56 5.22e-29 Vitiligo; CRC cis rs7737355 0.898 rs26007 chr5:131006356 T/A cg06307176 chr5:131281290 NA 0.41 5.89 0.31 9.65e-9 Life satisfaction; CRC cis rs873946 0.648 rs12767283 chr10:134557094 C/G cg06453172 chr10:134556979 INPP5A -0.67 -7.86 -0.4 5.54e-14 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CRC cis rs514406 0.798 rs4351588 chr1:53263826 A/T cg08859206 chr1:53392774 SCP2 0.61 10.11 0.49 4.34e-21 Monocyte count; CRC cis rs11690935 0.550 rs62183785 chr2:172866976 G/A cg13550731 chr2:172543902 DYNC1I2 0.61 8.8 0.44 7.61e-17 Schizophrenia; CRC cis rs270601 0.770 rs1007602 chr5:131602166 T/C cg04518342 chr5:131593106 PDLIM4 0.52 9.68 0.47 1.19e-19 Acylcarnitine levels; CRC cis rs637571 0.522 rs538954 chr11:65756808 A/G cg17985854 chr11:65770987 BANF1;EIF1AD 0.53 9.13 0.45 7.28e-18 Eosinophil percentage of white cells; CRC cis rs4243830 0.850 rs6679649 chr1:6606608 C/T cg05709478 chr1:6581295 PLEKHG5 0.58 7.71 0.39 1.52e-13 Body mass index; CRC cis rs1129187 0.967 rs3805952 chr6:42937126 C/T cg27588902 chr6:42928151 GNMT -0.39 -6.98 -0.36 1.66e-11 Alzheimer's disease in APOE e4+ carriers; CRC cis rs801193 0.839 rs6968619 chr7:66068867 T/C cg11764359 chr7:65958608 NA -0.5 -7.63 -0.39 2.51e-13 Aortic root size; CRC cis rs12971120 0.947 rs34676212 chr18:72170006 A/G cg26446133 chr18:72167187 CNDP2 -0.76 -15.66 -0.65 1.1e-41 Refractive error; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg03397750 chr1:51810503 TTC39A 0.41 6.77 0.35 6e-11 Liver disease severity in Alagille syndrome; CRC cis rs76878669 0.561 rs7105015 chr11:66159390 A/G cg18002602 chr11:66138449 SLC29A2 0.31 6.61 0.34 1.57e-10 Educational attainment (years of education); CRC cis rs1185460 0.967 rs4454730 chr11:118937444 G/A cg23280166 chr11:118938394 VPS11 0.44 6.71 0.35 8.71e-11 Coronary artery disease; CRC cis rs873946 0.586 rs3793684 chr10:134568645 G/A cg06453172 chr10:134556979 INPP5A -0.69 -8.23 -0.41 4.32e-15 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CRC cis rs10782582 0.569 rs1770892 chr1:76389359 T/C cg10523679 chr1:76189770 ACADM -0.41 -5.81 -0.31 1.46e-8 Daytime sleep phenotypes; CRC cis rs8017423 0.647 rs1958346 chr14:90824011 G/T cg14092571 chr14:90743983 NA 0.38 5.92 0.31 8.07e-9 Mortality in heart failure; CRC cis rs172166 0.543 rs1150691 chr6:28168033 A/G cg02683197 chr6:28174875 NA 0.51 7.08 0.36 8.59e-12 Cardiac Troponin-T levels; CRC cis rs3106136 0.967 rs3106135 chr4:95138308 G/A cg11021082 chr4:95130006 SMARCAD1 -0.46 -7.18 -0.37 4.6e-12 Capecitabine sensitivity; CRC trans rs13434995 0.842 rs73236149 chr4:56373474 C/T cg05873268 chr16:1290058 TPSAB1 -0.43 -6.24 -0.33 1.35e-9 Adiponectin levels; CRC cis rs939584 1.000 rs2903489 chr2:649638 C/T cg03610516 chr2:642275 NA -0.41 -5.7 -0.3 2.65e-8 Body mass index; CRC cis rs7119 0.931 rs7176875 chr15:77832675 A/G cg27398640 chr15:77910606 LINGO1 0.37 6.43 0.33 4.39e-10 Type 2 diabetes; CRC cis rs7647973 0.580 rs12637576 chr3:49237334 C/T cg03060546 chr3:49711283 APEH 0.44 6.37 0.33 6.21e-10 Menarche (age at onset); CRC cis rs8014671 0.597 rs8021180 chr14:70783943 A/G cg05203877 chr14:70655686 SLC8A3 -0.35 -6.7 -0.35 9.2e-11 Prostate cancer; CRC cis rs796364 0.951 rs971232 chr2:200792881 C/T cg25936922 chr2:200820526 C2orf60;C2orf47 0.7 7.65 0.39 2.21e-13 Schizophrenia; CRC cis rs7317038 1.000 rs7317038 chr13:114012898 C/T cg24344662 chr13:114018021 GRTP1 -0.42 -6.46 -0.34 3.78e-10 Mean platelet volume; CRC cis rs597539 0.652 rs10792001 chr11:68637737 G/C cg06112835 chr11:68658793 MRPL21 0.43 6.88 0.35 3.11e-11 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs155076 1.000 rs195570 chr13:21867580 T/G cg25811766 chr13:21894605 NA -0.56 -6.01 -0.31 4.93e-9 White matter hyperintensity burden; CRC trans rs7267979 1.000 rs4813563 chr20:25365340 T/C cg17903999 chr18:56338584 MALT1 0.4 6.69 0.35 9.66e-11 Liver enzyme levels (alkaline phosphatase); CRC trans rs1728785 0.901 rs1170437 chr16:68607943 C/T cg04657470 chr2:198365150 HSPE1;HSPD1 0.59 6.98 0.36 1.59e-11 Ulcerative colitis; CRC cis rs78456975 0.943 rs7602369 chr2:1574754 T/C cg26248373 chr2:1572462 NA -0.66 -7.78 -0.39 9.25e-14 Placebo response in major depressive disorder (% change in symptom score); CRC cis rs6582630 0.555 rs10785443 chr12:38463792 A/C cg13010199 chr12:38710504 ALG10B 0.43 5.82 0.31 1.43e-8 Drug-induced liver injury (flucloxacillin); CRC cis rs3858526 0.508 rs10838734 chr11:5876325 T/G cg02574844 chr11:5959923 NA -0.49 -7.32 -0.37 1.91e-12 DNA methylation (variation); CRC cis rs873946 0.504 rs12254034 chr10:134571007 T/C cg26818010 chr10:134567672 INPP5A -0.61 -8.56 -0.43 4.52e-16 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CRC cis rs7312933 0.618 rs7315968 chr12:42637086 G/A cg19980929 chr12:42632907 YAF2 0.48 7.47 0.38 7.34e-13 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CRC trans rs1814175 0.676 rs1851859 chr11:49860405 A/T cg11707556 chr5:10655725 ANKRD33B -0.51 -9.77 -0.47 5.69e-20 Height; CRC trans rs4942242 0.512 rs9533552 chr13:44187194 C/T cg19169023 chr15:41853346 TYRO3 -0.61 -8.44 -0.42 1e-15 Response to tocilizumab in rheumatoid arthritis; CRC cis rs12908161 1.000 rs34570071 chr15:85280212 T/A cg11189052 chr15:85197271 WDR73 0.57 8.22 0.41 4.83e-15 Schizophrenia; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg20418281 chr17:27717751 TAOK1 0.45 6.22 0.32 1.53e-9 Anxiety disorder; CRC cis rs9457247 0.967 rs1187532 chr6:167382020 G/A cg23791538 chr6:167370224 RNASET2 -0.38 -5.97 -0.31 6.08e-9 Crohn's disease; CRC cis rs9372498 0.572 rs62422230 chr6:118959436 T/C cg15382696 chr6:118971807 C6orf204 0.56 6.86 0.35 3.34e-11 Diastolic blood pressure; CRC cis rs5769765 0.773 rs9616378 chr22:50311973 A/G cg22709217 chr22:50311962 ALG12;CRELD2 -1.12 -18.4 -0.71 1.66e-52 Schizophrenia; CRC trans rs2898290 0.622 rs1478890 chr8:11355602 C/G cg16141378 chr3:129829833 LOC729375 0.44 6.91 0.36 2.59e-11 Systolic blood pressure; CRC cis rs208520 0.507 rs7755710 chr6:66783355 G/A cg07460842 chr6:66804631 NA -1.14 -23.94 -0.8 4.92e-74 Exhaled nitric oxide output; CRC cis rs9503598 0.783 rs9503599 chr6:3451048 T/C cg00476032 chr6:3446245 SLC22A23 0.38 6.2 0.32 1.7e-9 Cognitive ability (multi-trait analysis);Cognitive ability;Intelligence (multi-trait analysis); CRC cis rs317689 0.690 rs595348 chr12:69638610 T/C cg14784868 chr12:69753453 YEATS4 0.46 5.84 0.31 1.27e-8 Response to diuretic therapy; CRC cis rs11212617 0.967 rs227054 chr11:108257943 A/G cg14761454 chr11:108092087 ATM;NPAT 0.41 6.01 0.31 4.91e-9 Response to metformin in type 2 diabetes (glycemic); CRC cis rs995000 0.931 rs1168097 chr1:63120371 C/T cg19896129 chr1:63156450 NA -0.41 -6.23 -0.33 1.39e-9 Triglyceride levels; CRC cis rs6502050 0.835 rs11077981 chr17:80147243 C/T cg02741985 chr17:80059408 CCDC57 0.44 7.18 0.37 4.6e-12 Life satisfaction; CRC cis rs4481887 0.861 rs10788778 chr1:248481551 T/C cg00666640 chr1:248458726 OR2T12 0.55 9.55 0.47 3.15e-19 Common traits (Other); CRC cis rs2404602 0.532 rs744336 chr15:76674624 T/C cg23625390 chr15:77176239 SCAPER 0.58 9.19 0.45 4.54e-18 Blood metabolite levels; CRC cis rs7095944 0.614 rs11245354 chr10:126450125 C/A cg08799069 chr10:126477246 METTL10 -0.44 -6.95 -0.36 1.99e-11 Asthma; CRC trans rs7824557 0.606 rs1047950 chr8:11185096 G/C cg16141378 chr3:129829833 LOC729375 -0.41 -6.02 -0.31 4.57e-9 Retinal vascular caliber; CRC cis rs9649213 0.593 rs7807555 chr7:97957517 G/A cg08684580 chr7:98029266 BAIAP2L1 -0.32 -5.65 -0.3 3.44e-8 Prostate cancer (SNP x SNP interaction); CRC cis rs10911232 0.560 rs6697320 chr1:183037377 T/G ch.1.3577855R chr1:183094577 LAMC1 0.82 13.66 0.6 6.07e-34 Hypertriglyceridemia; CRC cis rs13256369 1.000 rs10103769 chr8:8573036 G/T cg06671706 chr8:8559999 CLDN23 0.55 7.93 0.4 3.44e-14 Obesity-related traits; CRC cis rs7917772 0.503 rs1536308 chr10:104288777 T/G cg22532475 chr10:104410764 TRIM8 -0.36 -6.62 -0.34 1.43e-10 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC cis rs4285028 0.699 rs4676758 chr3:121583415 T/C cg11130432 chr3:121712080 ILDR1 0.47 5.93 0.31 7.58e-9 Multiple sclerosis; CRC cis rs3540 0.597 rs12708583 chr15:91050271 C/T cg22089800 chr15:90895588 ZNF774 0.56 9.33 0.46 1.6e-18 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; CRC cis rs1448094 0.791 rs7303256 chr12:86333217 C/T cg25456477 chr12:86230367 RASSF9 -0.34 -5.83 -0.31 1.31e-8 Major depressive disorder; CRC cis rs4731207 0.698 rs16871295 chr7:124461288 C/G cg23710748 chr7:124431027 NA 0.37 6.05 0.32 4e-9 Cutaneous malignant melanoma; CRC trans rs17685 0.753 rs3757593 chr7:75678735 G/A cg19862616 chr7:65841803 NCRNA00174 -0.99 -18.63 -0.72 2.21e-53 Coffee consumption;Coffee consumption (cups per day); CRC cis rs35306767 0.903 rs12260800 chr10:927933 T/C cg20503657 chr10:835505 NA 0.94 11.83 0.55 3.85e-27 Eosinophil percentage of granulocytes; CRC cis rs7945705 0.870 rs10840142 chr11:8906078 A/G cg12365402 chr11:9010492 NRIP3 0.48 7.84 0.4 6.53e-14 Hemoglobin concentration; CRC cis rs10751667 0.643 rs10902234 chr11:935578 A/G ch.11.42038R chr11:967971 AP2A2 0.58 9.85 0.48 3.1e-20 Alzheimer's disease (late onset); CRC cis rs6121246 0.559 rs6060857 chr20:30300222 A/G cg13852791 chr20:30311386 BCL2L1 0.76 14.71 0.63 5.4e-38 Mean corpuscular hemoglobin; CRC cis rs3540 0.960 rs8030299 chr15:91026459 G/A cg04176472 chr15:90893244 GABARAPL3 0.34 6.01 0.31 4.91e-9 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; CRC cis rs9487051 0.676 rs2884013 chr6:109599952 C/T cg01475377 chr6:109611718 NA -0.37 -6.54 -0.34 2.41e-10 Reticulocyte fraction of red cells; CRC cis rs7586879 0.789 rs17046737 chr2:25127835 C/T cg04586622 chr2:25135609 ADCY3 -0.57 -9.57 -0.47 2.57e-19 Body mass index; CRC cis rs2115630 0.653 rs61394864 chr15:85170174 T/C cg11189052 chr15:85197271 WDR73 -0.69 -11.87 -0.55 2.62e-27 P wave terminal force; CRC cis rs939658 0.683 rs1560895 chr15:79468082 A/G cg17916960 chr15:79447300 NA -0.45 -7.26 -0.37 2.77e-12 Refractive error; CRC trans rs1656966 1.000 rs1656966 chr3:186466252 C/T cg04475877 chr11:2951676 PHLDA2 0.39 6.01 0.31 4.83e-9 Myopia (pathological); CRC cis rs1862618 0.853 rs252916 chr5:56121788 G/C cg20203395 chr5:56204925 C5orf35 -0.66 -8.08 -0.41 1.25e-14 Initial pursuit acceleration; CRC cis rs13118159 0.550 rs28733902 chr4:1374789 A/G cg02018176 chr4:1364513 KIAA1530 0.71 12.25 0.56 1.07e-28 Longevity; CRC cis rs637571 0.522 rs12797319 chr11:65735672 G/A cg26695010 chr11:65641043 EFEMP2 -0.4 -5.79 -0.3 1.67e-8 Eosinophil percentage of white cells; CRC cis rs5771225 0.544 rs1555048 chr22:50688348 A/G cg16473166 chr22:50639996 SELO 0.51 6.42 0.33 4.86e-10 Late-onset Alzheimer's disease; CRC cis rs728616 0.681 rs36023925 chr10:81906846 T/C cg05935833 chr10:81318306 SFTPA2 -0.57 -6.61 -0.34 1.59e-10 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs801193 0.844 rs7779971 chr7:66161790 T/C cg11764359 chr7:65958608 NA 0.55 8.52 0.43 5.79e-16 Aortic root size; CRC cis rs9322193 1.000 rs58189451 chr6:149921388 G/A cg07701084 chr6:150067640 NUP43 0.5 6.89 0.36 2.86e-11 Lung cancer; CRC cis rs9788721 0.836 rs72738718 chr15:78735438 G/C cg18825076 chr15:78729989 IREB2 -0.46 -7.16 -0.37 5.14e-12 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio;Emphysema imaging phenotypes;Emphysema distribution in smoking;Local histogram emphysema pattern;Post bronchodilator FEV1/FVC ratio in COPD; CRC cis rs12134245 0.747 rs11164912 chr1:92005191 A/T cg07090678 chr1:91966139 CDC7 0.42 6.92 0.36 2.35e-11 Breast cancer; CRC cis rs10971721 0.822 rs72725387 chr9:33863671 G/A cg13495928 chr9:33750294 PRSS3 0.56 5.95 0.31 6.96e-9 Body mass index; CRC cis rs875971 0.545 rs4718364 chr7:66001340 C/A cg18876405 chr7:65276391 NA 0.44 6.21 0.32 1.58e-9 Aortic root size; CRC trans rs1413885 1.000 rs10789181 chr1:65816567 A/G cg26534493 chr8:28060551 NA -0.38 -6.14 -0.32 2.32e-9 Anticoagulant levels; CRC cis rs611744 0.647 rs2594357 chr8:109255989 A/G cg21045802 chr8:109455806 TTC35 0.41 6.55 0.34 2.26e-10 Dupuytren's disease; CRC cis rs1059312 0.772 rs11609637 chr12:129300202 T/G cg09035930 chr12:129282057 SLC15A4 0.53 8.89 0.44 4.06e-17 Systemic lupus erythematosus; CRC cis rs6973256 0.897 rs2911495 chr7:133331405 T/C cg10665199 chr7:133106180 EXOC4 -0.37 -5.68 -0.3 2.9e-8 Intelligence (multi-trait analysis); CRC cis rs6693567 0.874 rs698915 chr1:150388318 C/T cg17724175 chr1:150552817 MCL1 0.48 7.16 0.37 5.41e-12 Migraine; CRC cis rs9527 0.590 rs3740386 chr10:104931051 C/T cg15744005 chr10:104629667 AS3MT -0.31 -6.18 -0.32 1.91e-9 Arsenic metabolism; CRC cis rs6942756 1.000 rs66538149 chr7:128974061 G/A cg02491457 chr7:128862824 NA -0.75 -9.96 -0.48 1.36e-20 White matter hyperintensity burden; CRC cis rs7635838 0.557 rs347615 chr3:11277284 T/A cg00170343 chr3:11313890 ATG7 0.57 8.95 0.44 2.74e-17 HDL cholesterol; CRC cis rs6500602 0.727 rs55939215 chr16:4541390 C/G cg14951292 chr16:4525986 HMOX2;NMRAL1 0.6 9.37 0.46 1.16e-18 Schizophrenia; CRC cis rs7666738 0.830 rs2865949 chr4:99039967 A/G cg05340658 chr4:99064831 C4orf37 0.6 9.45 0.46 6.36e-19 Colonoscopy-negative controls vs population controls; CRC cis rs1865760 0.532 rs2006736 chr6:26086017 C/T cg18357526 chr6:26021779 HIST1H4A 0.43 6.09 0.32 3.08e-9 Height; CRC trans rs1814175 0.645 rs11040699 chr11:50023798 C/G cg11707556 chr5:10655725 ANKRD33B -0.52 -10.25 -0.49 1.36e-21 Height; CRC cis rs9648716 1.000 rs10244133 chr7:140603329 G/T cg10747023 chr7:140774559 NA 0.44 5.8 0.3 1.52e-8 Type 2 diabetes; CRC cis rs9682041 1.000 rs4955588 chr3:170072864 C/A cg11886554 chr3:170076028 SKIL 0.72 8.13 0.41 8.58e-15 Glomerular filtration rate in non diabetics (creatinine);Glomerular filtration rate (creatinine); CRC cis rs896854 0.738 rs509594 chr8:95967156 C/G cg16049864 chr8:95962084 TP53INP1 0.57 8.9 0.44 3.96e-17 Type 2 diabetes; CRC cis rs4653767 1.000 rs708775 chr1:226923264 G/A cg05049329 chr1:226924846 ITPKB 0.41 9.05 0.45 1.29e-17 Parkinson's disease; CRC cis rs875971 0.522 rs34973832 chr7:65396204 A/G cg18876405 chr7:65276391 NA 0.65 11.95 0.55 1.41e-27 Aortic root size; CRC cis rs7584330 0.554 rs75918156 chr2:238426287 G/A cg08992911 chr2:238395768 MLPH 0.47 5.76 0.3 1.89e-8 Prostate cancer; CRC cis rs9467773 0.526 rs3734536 chr6:26365346 C/G cg09904177 chr6:26538194 HMGN4 -0.45 -6.27 -0.33 1.16e-9 Intelligence (multi-trait analysis); CRC cis rs6912958 0.781 rs2284908 chr6:88194500 A/G cg12350822 chr6:88032061 C6orf162;GJB7 -0.36 -6.74 -0.35 7.11e-11 Monocyte percentage of white cells; CRC cis rs1799949 1.000 rs11652332 chr17:41295489 G/A cg19454999 chr17:41278357 BRCA1;NBR2 0.53 8.26 0.41 3.49e-15 Menopause (age at onset); CRC cis rs1348850 0.519 rs1544002 chr2:178529534 C/T cg22681709 chr2:178499509 PDE11A -0.41 -7.54 -0.38 4.51e-13 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs807669 0.903 rs807667 chr22:19161327 A/G cg02655711 chr22:19163373 SLC25A1 -0.97 -20.74 -0.75 1.06e-61 Metabolite levels; CRC cis rs6424115 0.867 rs2501432 chr1:24201920 T/C cg10978503 chr1:24200527 CNR2 0.61 11.06 0.52 2.22e-24 Immature fraction of reticulocytes; CRC cis rs7793919 0.652 rs10228886 chr7:4783224 C/T cg09789173 chr7:4769017 FOXK1 -0.64 -10.85 -0.51 1.19e-23 Mosquito bite size; CRC cis rs7074356 0.704 rs1417220 chr10:82168154 G/A cg27171509 chr10:82033454 MAT1A -0.45 -7.78 -0.39 9.46e-14 Borderline personality disorder; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg06041595 chr7:140714854 MRPS33 0.41 6.59 0.34 1.77e-10 Liver disease severity in Alagille syndrome; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg00949670 chr12:120967105 COQ5 0.43 6.22 0.32 1.5e-9 Response to antipsychotic treatment; CRC trans rs7819412 0.521 rs4451268 chr8:11034859 A/G cg06636001 chr8:8085503 FLJ10661 -0.42 -6.1 -0.32 2.95e-9 Triglycerides; CRC cis rs597539 0.731 rs664229 chr11:68624483 C/G cg06028808 chr11:68637592 NA 0.41 6.49 0.34 3.15e-10 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs7677751 0.806 rs4864857 chr4:55089814 T/C cg00691999 chr4:55094011 PDGFRA 0.42 6.02 0.31 4.75e-9 Corneal astigmatism; CRC cis rs3768617 0.510 rs3768615 chr1:183103604 A/G ch.1.3577855R chr1:183094577 LAMC1 0.89 15.63 0.65 1.44e-41 Fuchs's corneal dystrophy; CRC cis rs1018836 0.851 rs2023624 chr8:91618874 T/C cg16814680 chr8:91681699 NA -0.77 -12.25 -0.56 1.16e-28 Ejection fraction in Tripanosoma cruzi seropositivity; CRC cis rs10504229 0.636 rs10958525 chr8:58051528 C/A cg02290350 chr8:58132656 NA -0.45 -5.75 -0.3 2.02e-8 Developmental language disorder (linguistic errors); CRC cis rs853679 0.546 rs200952 chr6:27836976 C/T cg23259851 chr6:27775964 HIST1H2AI;HIST1H2BL 0.71 5.93 0.31 7.83e-9 Depression; CRC cis rs1355223 0.583 rs2956074 chr11:34864880 T/C cg24088639 chr11:34937564 PDHX;APIP -0.58 -8.51 -0.42 6.33e-16 Systemic lupus erythematosus and Systemic sclerosis; CRC cis rs763014 0.966 rs4984677 chr16:671682 A/G cg04497992 chr16:616212 NHLRC4 0.43 6.84 0.35 3.8e-11 Height; CRC cis rs13217239 0.646 rs4403259 chr6:26997617 C/T cg12292205 chr6:26970375 C6orf41 0.55 9.25 0.45 2.82e-18 Schizophrenia; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg26228351 chr1:200992656 KIF21B 0.44 6.14 0.32 2.37e-9 Anxiety disorder; CRC cis rs2952156 1.000 rs2643194 chr17:37853048 C/T cg11212589 chr17:38028394 ZPBP2 0.37 6.14 0.32 2.33e-9 Asthma; CRC cis rs3741151 0.773 rs7951072 chr11:73221721 G/A cg17517138 chr11:73019481 ARHGEF17 0.98 8.06 0.41 1.41e-14 GIP levels in response to oral glucose tolerance test (120 minutes); CRC cis rs1552244 0.626 rs2886396 chr3:10037670 C/T cg00166722 chr3:10149974 C3orf24 0.61 8.0 0.4 2.17e-14 Alzheimer's disease; CRC cis rs2404602 0.716 rs8039545 chr15:76707247 A/G cg23625390 chr15:77176239 SCAPER 0.47 6.92 0.36 2.32e-11 Blood metabolite levels; CRC trans rs7395662 1.000 rs10769390 chr11:48618222 A/G cg21153622 chr11:89784906 NA -0.45 -7.22 -0.37 3.57e-12 HDL cholesterol; CRC cis rs9368481 0.761 rs9357030 chr6:26985026 G/T cg12292205 chr6:26970375 C6orf41 -0.75 -12.14 -0.56 2.74e-28 Autism spectrum disorder or schizophrenia; CRC cis rs7618915 0.501 rs6617 chr3:52740182 C/G cg11645453 chr3:52864694 ITIH4 0.36 6.5 0.34 2.93e-10 Bipolar disorder; CRC cis rs1348850 0.537 rs3770010 chr2:178537796 T/C cg02961200 chr2:178257176 LOC100130691;AGPS 0.59 8.38 0.42 1.6e-15 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs9916302 0.904 rs9898170 chr17:37510092 T/C cg03013999 chr17:37608204 MED1 -0.46 -6.85 -0.35 3.7e-11 Glomerular filtration rate (creatinine); CRC cis rs28386778 0.863 rs3760254 chr17:61851751 T/G cg06873352 chr17:61820015 STRADA 0.76 14.31 0.62 1.87e-36 Prudent dietary pattern; CRC cis rs4862750 0.872 rs6811569 chr4:187897988 A/G cg07414643 chr4:187882934 NA -0.36 -6.07 -0.32 3.54e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs79349575 0.783 rs4793995 chr17:47019399 A/C cg00947319 chr17:47005597 UBE2Z -0.34 -5.89 -0.31 9.32e-9 Type 2 diabetes; CRC trans rs8064024 0.508 rs2037912 chr16:4933939 G/C cg19252218 chr17:41477271 ARL4D -0.41 -5.99 -0.31 5.44e-9 Cancer; CRC cis rs60871478 0.636 rs73045423 chr7:893952 G/A cg05535760 chr7:792225 HEATR2 -0.9 -10.05 -0.48 6.51e-21 Cerebrospinal P-tau181p levels; CRC cis rs9916302 0.861 rs632202 chr17:37453294 C/A cg03013999 chr17:37608204 MED1 -0.48 -7.43 -0.38 9.53e-13 Glomerular filtration rate (creatinine); CRC cis rs7818382 0.967 rs7812465 chr8:96050557 C/T cg09323728 chr8:95962352 TP53INP1 0.43 6.94 0.36 2.15e-11 Alzheimer's disease (late onset); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg22708233 chr11:47198576 ARFGAP2 0.41 7.16 0.37 5.22e-12 Liver disease severity in Alagille syndrome; CRC cis rs7591163 0.959 rs2396497 chr2:228724139 T/C cg23807890 chr2:228736357 WDR69 -0.47 -6.54 -0.34 2.36e-10 Blood pressure; CRC cis rs60843830 0.661 rs62116681 chr2:104197 A/T cg25945732 chr2:264204 ACP1;SH3YL1 0.45 6.26 0.33 1.22e-9 Spherical equivalent (joint analysis main effects and education interaction); CRC cis rs4243830 0.850 rs7540913 chr1:6581877 C/T cg06972903 chr1:6580525 PLEKHG5 0.43 5.64 0.3 3.6e-8 Body mass index; CRC cis rs796364 1.000 rs281783 chr2:200751582 G/A cg25936922 chr2:200820526 C2orf60;C2orf47 0.71 7.91 0.4 4e-14 Schizophrenia; CRC cis rs6502050 0.835 rs8065210 chr17:80090960 G/A cg22110888 chr17:80059540 CCDC57 0.4 6.36 0.33 6.76e-10 Life satisfaction; CRC trans rs1814175 0.566 rs1811673 chr11:49602134 A/G cg03929089 chr4:120376271 NA -0.77 -10.47 -0.5 2.5e-22 Height; CRC cis rs9470366 0.527 rs733590 chr6:36645203 A/G cg03032677 chr6:36648794 CDKN1A 0.41 6.16 0.32 2.17e-9 QRS duration; CRC cis rs7662987 0.517 rs2602873 chr4:100039032 G/C cg13256891 chr4:100009986 ADH5 0.63 8.54 0.43 4.99e-16 Smoking initiation; CRC cis rs2857078 0.654 rs4793083 chr17:42312973 C/T cg13607699 chr17:42295918 UBTF -0.76 -12.47 -0.57 1.69e-29 Red cell distribution width;Reticulocyte count; CRC cis rs12048904 0.619 rs10783153 chr1:101328230 T/C cg16556008 chr1:101360663 SLC30A7;EXTL2 0.92 15.05 0.64 2.59e-39 Multiple sclerosis; CRC cis rs12143943 0.966 rs3795567 chr1:204585738 A/G cg17419461 chr1:204415978 PIK3C2B 0.38 6.0 0.31 5.26e-9 Cognitive performance; CRC trans rs9329221 0.905 rs4841329 chr8:10253098 A/G cg06636001 chr8:8085503 FLJ10661 -0.52 -8.05 -0.41 1.52e-14 Neuroticism; CRC trans rs9885413 0.502 rs13362072 chr5:110280203 C/G cg13894719 chr4:56534223 NA -0.56 -6.01 -0.31 4.8e-9 Mortality in heart failure; CRC cis rs10256972 0.577 rs2949179 chr7:1209885 C/G cg18402987 chr7:1209562 NA 0.61 9.69 0.47 1.03e-19 Longevity;Endometriosis; CRC cis rs7215564 0.908 rs2316061 chr17:78663660 A/G cg09596252 chr17:78655493 RPTOR 0.56 6.17 0.32 1.97e-9 Myopia (pathological); CRC cis rs6504622 0.935 rs17608961 chr17:45029668 G/T cg16759221 chr17:45003025 GOSR2 0.46 7.25 0.37 3.09e-12 Orofacial clefts; CRC cis rs11122272 0.735 rs2486746 chr1:231497324 C/T cg06096015 chr1:231504339 EGLN1 0.37 5.74 0.3 2.14e-8 Hemoglobin concentration; CRC cis rs1059312 0.808 rs11059921 chr12:129289919 C/T cg09035930 chr12:129282057 SLC15A4 0.5 8.33 0.42 2.18e-15 Systemic lupus erythematosus; CRC cis rs8058578 1.000 rs3747481 chr16:30666367 C/T cg02466173 chr16:30829666 NA -0.81 -12.15 -0.56 2.69e-28 Multiple myeloma; CRC cis rs4862750 0.872 rs13101408 chr4:187894777 G/A cg27532560 chr4:187881888 NA -0.56 -10.26 -0.49 1.31e-21 Lobe attachment (rater-scored or self-reported); CRC cis rs6998277 1.000 rs6998277 chr8:103639941 T/C cg10187029 chr8:103597600 NA 0.79 10.13 0.49 3.74e-21 Migraine; CRC cis rs7945718 0.934 rs4553350 chr11:12759834 A/G cg25843174 chr11:12811716 TEAD1 -0.48 -8.78 -0.44 8.85e-17 Educational attainment (years of education); CRC trans rs877282 0.945 rs12782447 chr10:771870 C/T cg22713356 chr15:30763199 NA 1.26 15.74 0.66 5.34e-42 Uric acid levels; CRC cis rs8058578 0.832 rs3812999 chr16:30773605 G/T cg00531865 chr16:30841666 NA -0.47 -6.6 -0.34 1.66e-10 Multiple myeloma; CRC cis rs4332037 0.707 rs62435132 chr7:1891315 C/T cg21155852 chr7:2048760 MAD1L1 -0.42 -6.07 -0.32 3.56e-9 Bipolar disorder; CRC cis rs3749237 1.000 rs11920900 chr3:49823024 G/C cg03060546 chr3:49711283 APEH 0.55 8.3 0.42 2.77e-15 Resting heart rate; CRC trans rs9329221 0.572 rs4841295 chr8:10105115 C/T cg06636001 chr8:8085503 FLJ10661 0.55 8.23 0.41 4.32e-15 Neuroticism; CRC cis rs6912958 0.559 rs369674 chr6:88043402 C/G cg08069147 chr6:88032118 GJB7;C6orf162 -0.71 -11.45 -0.53 8.76e-26 Monocyte percentage of white cells; CRC cis rs10256972 0.591 rs6950319 chr7:1161324 A/G cg04025307 chr7:1156635 C7orf50 0.78 13.08 0.58 8.95e-32 Longevity;Endometriosis; CRC cis rs853679 0.550 rs1225598 chr6:28160799 T/G cg12172441 chr6:28176163 NA 0.69 9.19 0.45 4.69e-18 Depression; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg00381330 chr20:25228575 PYGB 0.46 6.31 0.33 8.81e-10 Response to antipsychotic treatment; CRC cis rs7267979 1.000 rs4815417 chr20:25379526 C/T cg08601574 chr20:25228251 PYGB -0.36 -5.89 -0.31 9.34e-9 Liver enzyme levels (alkaline phosphatase); CRC cis rs2346177 0.554 rs34854267 chr2:46708542 T/C cg02822958 chr2:46747628 ATP6V1E2 0.41 5.75 0.3 2e-8 HDL cholesterol; CRC cis rs12908161 1.000 rs34900908 chr15:85257599 G/A cg17507749 chr15:85114479 UBE2QP1 0.63 9.11 0.45 8.42e-18 Schizophrenia; CRC trans rs800082 0.934 rs6788831 chr3:144290498 G/T cg24215973 chr2:240111563 HDAC4 -0.54 -7.68 -0.39 1.85e-13 Smoking behavior; CRC cis rs10540 0.915 rs35389167 chr11:460765 A/G cg15790184 chr11:494944 RNH1 0.59 6.1 0.32 2.95e-9 Body mass index; CRC cis rs644799 1.000 rs3177463 chr11:95502128 G/C cg25478527 chr11:95522999 CEP57;FAM76B 0.52 7.62 0.39 2.74e-13 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs2777491 0.915 rs7180418 chr15:41629502 A/C cg18705301 chr15:41695430 NDUFAF1 -0.69 -11.42 -0.53 1.17e-25 Ulcerative colitis; CRC cis rs9467711 0.606 rs12174631 chr6:26373150 C/T cg16898833 chr6:26189333 HIST1H4D 0.76 6.58 0.34 1.84e-10 Autism spectrum disorder or schizophrenia; CRC cis rs11758351 0.588 rs2050948 chr6:26234952 A/G cg01420254 chr6:26195488 NA 0.73 8.07 0.41 1.31e-14 Gout;Renal underexcretion gout; CRC cis rs780096 0.814 rs780093 chr2:27742603 T/C cg24768116 chr2:27665128 KRTCAP3 -0.29 -6.33 -0.33 8.24e-10 Total body bone mineral density; CRC cis rs10229583 0.527 rs1440971 chr7:127272400 C/T cg01233922 chr7:127693937 SND1 0.47 6.91 0.36 2.57e-11 Type 2 diabetes; CRC cis rs9894429 0.966 rs7405901 chr17:79587813 T/C cg18240062 chr17:79603768 NPLOC4 0.56 9.34 0.46 1.54e-18 Eye color traits; CRC cis rs3764563 1.000 rs11673070 chr19:15746095 A/G cg20725493 chr19:15740067 CYP4F8 -0.72 -7.47 -0.38 7.09e-13 Inflammatory biomarkers; CRC cis rs7301826 0.651 rs7132657 chr12:131285187 T/C cg11011512 chr12:131303247 STX2 0.39 5.75 0.3 2.04e-8 Plasma plasminogen activator levels; CRC cis rs1784581 0.569 rs9365357 chr6:162414913 A/G cg17173639 chr6:162384350 PARK2 0.61 9.89 0.48 2.34e-20 Itch intensity from mosquito bite; CRC cis rs2180341 1.000 rs3798852 chr6:127636733 A/G cg24812749 chr6:127587940 RNF146 0.95 13.75 0.6 2.59e-34 Breast cancer; CRC cis rs10197940 0.578 rs6718653 chr2:152346118 C/A cg19508488 chr2:152266495 RIF1 0.46 6.66 0.34 1.16e-10 Lung cancer; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg03934443 chr10:134639821 NA -0.37 -6.0 -0.31 5.21e-9 Liver disease severity in Alagille syndrome; CRC cis rs758324 0.947 rs13154286 chr5:131160189 A/G cg06307176 chr5:131281290 NA 0.42 6.23 0.32 1.45e-9 Alzheimer's disease in APOE e4- carriers; CRC cis rs897984 0.511 rs7196726 chr16:31092075 G/A cg00531865 chr16:30841666 NA -0.41 -5.91 -0.31 8.45e-9 Dementia with Lewy bodies; CRC cis rs4862750 0.914 rs1346127 chr4:187876389 C/T cg27532560 chr4:187881888 NA 0.52 9.43 0.46 7.81e-19 Lobe attachment (rater-scored or self-reported); CRC cis rs8064299 0.597 rs6501736 chr17:72775358 G/A cg25054828 chr17:72772726 NAT9;TMEM104 0.83 14.21 0.62 4.78e-36 Monocyte count; CRC cis rs9291683 0.551 rs62295971 chr4:9978142 G/A cg00071950 chr4:10020882 SLC2A9 0.64 11.88 0.55 2.61e-27 Bone mineral density; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg17470723 chr8:74884337 TCEB1 -0.4 -5.99 -0.31 5.39e-9 Myopia (pathological); CRC cis rs780096 0.506 rs1647286 chr2:27714517 A/T cg12000995 chr2:27665139 KRTCAP3 -0.34 -7.17 -0.37 4.95e-12 Total body bone mineral density; CRC trans rs916888 0.821 rs199513 chr17:44856932 A/G cg22433210 chr17:43662623 NA -0.79 -8.93 -0.44 2.98e-17 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs1697139 0.583 rs11739603 chr5:66540687 C/T cg16691251 chr5:66510806 NA 0.42 7.32 0.37 1.94e-12 Breast cancer; CRC cis rs10493773 0.532 rs12064199 chr1:86187073 A/T cg17807903 chr1:86174739 ZNHIT6 -0.56 -15.11 -0.64 1.48e-39 Urate levels in overweight individuals; CRC cis rs2032447 0.832 rs6922788 chr6:26052291 C/T cg04800585 chr6:26043546 HIST1H2BB 0.51 7.67 0.39 1.93e-13 Intelligence (multi-trait analysis); CRC cis rs896543 0.702 rs6711222 chr2:237494444 C/T cg25295825 chr2:237489920 CXCR7 0.46 7.55 0.38 4.27e-13 Alcohol dependence (age at onset); CRC cis rs3858526 0.523 rs10769289 chr11:5886607 C/T cg02574844 chr11:5959923 NA -0.51 -7.61 -0.39 2.89e-13 DNA methylation (variation); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg08267591 chr2:165693745 COBLL1 0.39 6.27 0.33 1.11e-9 Liver disease severity in Alagille syndrome; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg08990198 chr1:202318195 PPP1R12B 0.56 7.24 0.37 3.16e-12 Thyroid stimulating hormone; CRC cis rs6502050 0.805 rs4789721 chr17:80157453 T/C cg02741985 chr17:80059408 CCDC57 0.42 6.99 0.36 1.51e-11 Life satisfaction; CRC cis rs2274273 0.905 rs4652 chr14:55605036 A/C cg23234261 chr14:55582407 NA -0.3 -5.91 -0.31 8.46e-9 Protein biomarker; CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg14458654 chr3:174095293 NA -0.38 -6.32 -0.33 8.46e-10 Obesity-related traits; CRC cis rs6426558 0.572 rs2670471 chr1:227454328 T/C cg10327440 chr1:227177885 CDC42BPA 0.43 6.4 0.33 5.27e-10 Neutrophil percentage of white cells; CRC cis rs2249694 1.000 rs4240522 chr10:135355557 C/T cg20169779 chr10:135381914 SYCE1 0.59 9.5 0.46 4.48e-19 Obesity-related traits; CRC cis rs7726839 0.540 rs58599998 chr5:596087 A/G cg14541582 chr5:601475 NA -0.36 -7.37 -0.38 1.42e-12 Obesity-related traits; CRC cis rs483180 0.512 rs606312 chr1:120222582 G/A cg19096424 chr1:120255104 PHGDH 0.46 6.59 0.34 1.71e-10 Macular telangiectasia type 2; CRC cis rs10791323 0.536 rs1944731 chr11:133726067 G/A cg15485101 chr11:133734466 NA 0.47 7.94 0.4 3.16e-14 Childhood ear infection; CRC trans rs1814175 0.935 rs1827017 chr11:49632592 C/G cg11707556 chr5:10655725 ANKRD33B -0.43 -8.08 -0.41 1.29e-14 Height; CRC cis rs4713118 0.955 rs34752872 chr6:27683244 A/T cg21204522 chr6:27730016 NA -0.41 -5.63 -0.3 3.86e-8 Parkinson's disease; CRC cis rs9322193 0.884 rs9397036 chr6:150172923 C/T cg07701084 chr6:150067640 NUP43 0.49 6.79 0.35 5.19e-11 Lung cancer; CRC cis rs1862618 0.713 rs832550 chr5:56182589 C/T cg24531977 chr5:56204891 C5orf35 -0.84 -10.92 -0.52 6.54e-24 Initial pursuit acceleration; CRC cis rs10189230 0.967 rs12479119 chr2:222354213 C/T cg14652038 chr2:222343519 EPHA4 0.52 10.02 0.48 8.14e-21 Urate levels in lean individuals; CRC cis rs7312774 0.881 rs60941459 chr12:107318583 T/C cg16260113 chr12:107380972 MTERFD3 0.74 7.38 0.38 1.29e-12 Severe influenza A (H1N1) infection; CRC cis rs870825 0.616 rs28445002 chr4:185648977 C/T cg04058563 chr4:185651563 MLF1IP 0.72 9.3 0.46 2.04e-18 Blood protein levels; CRC trans rs1814175 0.817 rs10769618 chr11:49822336 A/G cg03929089 chr4:120376271 NA -0.94 -17.85 -0.7 2.56e-50 Height; CRC trans rs2727020 0.576 rs1814175 chr11:49559172 T/C cg03929089 chr4:120376271 NA -0.91 -16.65 -0.68 1.46e-45 Coronary artery disease; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg21813546 chr1:182808991 DHX9 0.52 7.4 0.38 1.12e-12 Response to antipsychotic treatment; CRC cis rs9787249 0.957 rs2274949 chr1:40221067 G/A cg01941586 chr1:40203715 PPIE -0.42 -5.84 -0.31 1.24e-8 Blood protein levels; CRC cis rs10504229 1.000 rs57941207 chr8:58169821 A/G cg01721255 chr8:58191610 C8orf71 0.49 6.08 0.32 3.29e-9 Developmental language disorder (linguistic errors); CRC cis rs300703 0.542 rs300697 chr2:184496 C/T cg21211680 chr2:198530 NA -0.74 -9.02 -0.45 1.64e-17 Blood protein levels; CRC cis rs4713118 0.869 rs10214440 chr6:27702440 A/C cg21251018 chr6:28226885 NKAPL 0.38 5.62 0.3 3.99e-8 Parkinson's disease; CRC cis rs4566357 0.615 rs12474622 chr2:227912793 A/G cg11843606 chr2:227700838 RHBDD1 -0.44 -6.79 -0.35 5.1e-11 Coronary artery disease; CRC cis rs7402982 0.934 rs8027457 chr15:99204101 A/G cg03437748 chr15:99193247 IGF1R 0.73 11.89 0.55 2.4e-27 Birth weight; CRC cis rs7944584 1.000 rs7944584 chr11:47336320 A/T cg20307385 chr11:47447363 PSMC3 0.76 9.3 0.46 2.08e-18 Fasting blood glucose;Fasting blood glucose (BMI interaction); CRC cis rs1799949 0.965 rs8176310 chr17:41199913 T/C cg05368731 chr17:41323189 NBR1 0.6 9.12 0.45 7.81e-18 Menopause (age at onset); CRC cis rs1005277 0.579 rs176886 chr10:38403974 C/T cg25517755 chr10:38738941 LOC399744 -0.45 -6.47 -0.34 3.64e-10 Extrinsic epigenetic age acceleration; CRC cis rs473651 0.904 rs62196716 chr2:239356977 C/G cg18131467 chr2:239335373 ASB1 1.02 23.29 0.79 1.49e-71 Multiple system atrophy; CRC cis rs9818758 0.607 rs34326553 chr3:49134429 A/G cg07636037 chr3:49044803 WDR6 -0.74 -6.14 -0.32 2.39e-9 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; CRC cis rs7927771 0.832 rs11605672 chr11:47413733 A/G cg05585544 chr11:47624801 NA -0.52 -9.17 -0.45 5.19e-18 Subjective well-being; CRC cis rs2062225 1.000 rs1483533 chr2:111757918 T/C cg11729679 chr2:111877065 BCL2L11 -0.56 -5.64 -0.3 3.67e-8 Monocyte count; CRC cis rs10927875 0.894 rs10927878 chr1:16319957 C/T cg22431228 chr1:16359049 CLCNKA 0.36 6.38 0.33 5.87e-10 Dilated cardiomyopathy; CRC cis rs2404602 0.716 rs17363713 chr15:76746128 G/C cg03037974 chr15:76606532 NA 0.75 13.59 0.6 1.11e-33 Blood metabolite levels; CRC cis rs7605827 0.930 rs6431708 chr2:15638175 C/T cg19274914 chr2:15703543 NA 0.4 6.05 0.32 4e-9 Educational attainment (years of education); CRC cis rs6831352 0.918 rs4699712 chr4:100060490 A/T cg12011299 chr4:100065546 ADH4 -0.5 -9.49 -0.46 4.89e-19 Alcohol dependence; CRC cis rs10992471 0.729 rs7042335 chr9:95122547 C/T cg14631576 chr9:95140430 CENPP -0.4 -7.4 -0.38 1.14e-12 Visceral adipose tissue/subcutaneous adipose tissue ratio; CRC cis rs1499614 0.831 rs3800822 chr7:66147149 A/G cg25985355 chr7:65971099 NA 0.52 5.95 0.31 6.88e-9 Gout; CRC cis rs2688608 0.618 rs28553894 chr10:75489843 C/A cg16540259 chr10:75572220 NDST2 0.39 5.96 0.31 6.52e-9 Inflammatory bowel disease; CRC cis rs13118159 0.550 rs4974612 chr4:1364543 A/G cg02018176 chr4:1364513 KIAA1530 0.73 12.62 0.57 4.89e-30 Longevity; CRC cis rs6499255 0.951 rs12596823 chr16:69634757 A/C cg15192750 chr16:69999425 NA 0.57 7.53 0.38 4.78e-13 IgE levels; CRC cis rs2153535 0.580 rs1928184 chr6:8532108 T/A cg21535247 chr6:8435926 SLC35B3 0.49 7.43 0.38 9.47e-13 Motion sickness; CRC cis rs881375 0.967 rs10435844 chr9:123668199 G/T cg09419670 chr9:123605666 PSMD5;LOC253039 0.6 8.81 0.44 7.32e-17 Rheumatoid arthritis; CRC cis rs9811920 0.609 rs4479633 chr3:99654510 G/A cg07805332 chr3:99536008 MIR548G;C3orf26 0.51 7.68 0.39 1.84e-13 Axial length; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg02685901 chr6:43597772 MAD2L1BP;GTPBP2 0.49 6.42 0.33 4.71e-10 Thyroid stimulating hormone; CRC cis rs12476592 0.602 rs262508 chr2:63885280 G/C cg10828910 chr2:63850056 LOC388955 0.51 6.44 0.33 4.22e-10 Childhood ear infection; CRC cis rs981844 0.714 rs2405202 chr4:154705132 A/G cg10279832 chr4:154682576 RNF175 0.37 5.66 0.3 3.37e-8 Response to statins (LDL cholesterol change); CRC cis rs1545257 0.505 rs2584950 chr2:24632762 A/G cg06627628 chr2:24431161 ITSN2 -0.45 -6.63 -0.34 1.34e-10 Sjögren's syndrome; CRC cis rs62064224 0.714 rs62064225 chr17:30635429 C/T cg18200150 chr17:30822561 MYO1D 0.47 9.52 0.46 3.79e-19 Schizophrenia; CRC cis rs7633770 0.841 rs11709936 chr3:46680483 C/G cg11219411 chr3:46661640 NA 0.69 11.75 0.54 7.67e-27 Coronary artery disease; CRC cis rs523522 0.962 rs10744752 chr12:120900554 T/G cg27279351 chr12:120934652 DYNLL1 0.75 11.02 0.52 3.07e-24 High light scatter reticulocyte count; CRC cis rs62064224 0.546 rs1018866 chr17:30829664 A/C cg24550644 chr17:30846204 MYO1D -0.4 -7.1 -0.36 7.91e-12 Schizophrenia; CRC cis rs11583043 0.918 rs58029001 chr1:101393409 A/G cg16556008 chr1:101360663 SLC30A7;EXTL2 0.57 7.74 0.39 1.22e-13 Ulcerative colitis;Inflammatory bowel disease; CRC cis rs9611565 0.729 rs9611570 chr22:41782721 G/T cg06634786 chr22:41940651 POLR3H -0.63 -7.24 -0.37 3.19e-12 Vitiligo; CRC cis rs9311676 0.632 rs62259779 chr3:58425692 C/G cg06643156 chr3:58380774 PXK 0.43 6.53 0.34 2.5e-10 Systemic lupus erythematosus; CRC cis rs2046867 0.819 rs34132129 chr3:72829100 A/G cg25664220 chr3:72788482 NA -0.46 -6.42 -0.33 4.78e-10 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; CRC cis rs12188164 0.515 rs17562461 chr5:411361 C/T cg21972741 chr5:435613 AHRR 0.45 6.13 0.32 2.51e-9 Cystic fibrosis severity; CRC cis rs4689388 0.890 rs6446481 chr4:6295583 C/A cg00701064 chr4:6280414 WFS1 0.77 13.56 0.6 1.37e-33 Type 2 diabetes and other traits;Type 2 diabetes; CRC cis rs17826219 0.500 rs9891256 chr17:29072692 C/T cg01831904 chr17:28903510 LRRC37B2 -0.63 -6.46 -0.34 3.66e-10 Body mass index; CRC cis rs2832191 0.791 rs2832196 chr21:30497412 G/A cg24692254 chr21:30365293 RNF160 -0.67 -11.39 -0.53 1.42e-25 Dental caries; CRC cis rs10760158 0.832 rs4836848 chr9:124063352 G/A cg14417974 chr9:124058376 GSN -0.33 -5.68 -0.3 3e-8 Pulse pressure; CRC cis rs9611565 0.592 rs5996038 chr22:41965300 T/C cg03806693 chr22:41940476 POLR3H -0.9 -11.19 -0.53 7.31e-25 Vitiligo; CRC cis rs950169 0.580 rs17532346 chr15:85171495 A/C cg11189052 chr15:85197271 WDR73 0.61 8.77 0.44 9.49e-17 Schizophrenia; CRC trans rs771998 0.909 rs2252518 chr12:52381026 C/A cg04286455 chr5:77803462 LHFPL2 -0.38 -6.04 -0.32 4.18e-9 Post bronchodilator FEV1/FVC ratio; CRC cis rs9341808 0.655 rs9350846 chr6:80865481 T/A cg08355045 chr6:80787529 NA 0.42 6.79 0.35 5.2e-11 Sitting height ratio; CRC trans rs4073221 0.520 rs1108439 chr3:18201319 A/G cg19396872 chr19:8495671 MARCH2 0.64 6.2 0.32 1.74e-9 Parkinson's disease; CRC trans rs1005277 0.579 rs1740742 chr10:38518860 C/T cg23533926 chr12:111358616 MYL2 -0.56 -8.67 -0.43 2e-16 Extrinsic epigenetic age acceleration; CRC cis rs9648716 1.000 rs1267632 chr7:140487202 C/T cg10747023 chr7:140774559 NA 0.44 5.67 0.3 3.14e-8 Type 2 diabetes; CRC cis rs6432018 1.000 rs6432024 chr2:9743134 A/G cg12832956 chr2:9616023 IAH1 -0.37 -5.66 -0.3 3.39e-8 Heart rate variability traits; CRC cis rs651907 0.514 rs34301719 chr3:101417993 C/T cg12386194 chr3:101231763 SENP7 0.5 7.11 0.37 7.2e-12 Colorectal cancer; CRC cis rs10791323 0.604 rs2723615 chr11:133704567 C/T cg00579200 chr11:133705235 NA -0.41 -5.91 -0.31 8.52e-9 Childhood ear infection; CRC cis rs13256369 1.000 rs13282915 chr8:8570891 T/G cg00074818 chr8:8560427 CLDN23 0.37 6.85 0.35 3.67e-11 Obesity-related traits; CRC cis rs7917772 0.636 rs7069489 chr10:104525371 A/G cg22532475 chr10:104410764 TRIM8 -0.34 -5.86 -0.31 1.15e-8 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC cis rs10504229 0.683 rs1495866 chr8:58141128 T/C cg22535103 chr8:58192502 C8orf71 -0.7 -9.34 -0.46 1.47e-18 Developmental language disorder (linguistic errors); CRC cis rs12188164 0.900 rs72717425 chr5:438809 C/T cg16322479 chr5:444228 EXOC3;C5orf55 0.44 7.26 0.37 2.85e-12 Cystic fibrosis severity; CRC trans rs1814175 0.645 rs12364337 chr11:49942580 A/T cg03929089 chr4:120376271 NA -0.91 -16.07 -0.66 2.65e-43 Height; CRC cis rs9322193 0.923 rs9322209 chr6:150012362 A/G cg05861140 chr6:150128134 PCMT1 -0.35 -5.66 -0.3 3.33e-8 Lung cancer; CRC cis rs896854 0.684 rs10098778 chr8:95992020 C/T cg13393036 chr8:95962371 TP53INP1 -0.52 -8.85 -0.44 5.59e-17 Type 2 diabetes; CRC cis rs853679 0.517 rs3823180 chr6:28061744 G/A cg21251018 chr6:28226885 NKAPL 0.48 6.22 0.32 1.55e-9 Depression; CRC cis rs875971 0.862 rs2024192 chr7:66041447 G/T cg18876405 chr7:65276391 NA -0.52 -8.46 -0.42 8.81e-16 Aortic root size; CRC cis rs9894429 1.000 rs9748176 chr17:79584043 C/G cg21984481 chr17:79567631 NPLOC4 -0.52 -9.6 -0.47 2.17e-19 Eye color traits; CRC cis rs7613875 0.578 rs4688753 chr3:50074773 A/G cg05623727 chr3:50126028 RBM5 -0.56 -9.67 -0.47 1.28e-19 Body mass index; CRC cis rs796364 0.806 rs34510964 chr2:201010676 C/G cg23649088 chr2:200775458 C2orf69 -0.57 -5.9 -0.31 8.82e-9 Schizophrenia; CRC cis rs9549260 0.683 rs35594717 chr13:41240783 G/A cg21288729 chr13:41239152 FOXO1 0.51 6.58 0.34 1.82e-10 Red blood cell count; CRC trans rs1814175 0.791 rs7395713 chr11:49877887 A/G cg21153622 chr11:89784906 NA -0.38 -6.04 -0.32 4.27e-9 Height; CRC cis rs4555082 0.872 rs7153832 chr14:105730563 G/T cg06808227 chr14:105710500 BRF1 -0.61 -9.12 -0.45 7.57e-18 Mean platelet volume;Platelet distribution width; CRC cis rs9894429 0.646 rs58398000 chr17:79576923 G/A cg18240062 chr17:79603768 NPLOC4 -0.49 -7.8 -0.4 8.13e-14 Eye color traits; CRC cis rs1865760 0.929 rs12195653 chr6:25958621 A/G cg16482183 chr6:26056742 HIST1H1C 0.57 8.35 0.42 1.96e-15 Height; CRC cis rs728616 0.867 rs723193 chr10:81708155 G/T cg05935833 chr10:81318306 SFTPA2 -0.7 -7.74 -0.39 1.26e-13 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs1941023 0.584 rs10897057 chr11:60172273 A/T cg08716584 chr11:60157161 MS4A7 -0.57 -9.23 -0.45 3.44e-18 Congenital heart disease (maternal effect); CRC cis rs35306767 0.668 rs72760914 chr10:1070952 A/G cg26597838 chr10:835615 NA 0.66 8.54 0.43 4.99e-16 Eosinophil percentage of granulocytes; CRC cis rs1451375 0.698 rs11489736 chr7:50645372 G/A cg18232548 chr7:50535776 DDC 0.44 6.25 0.33 1.24e-9 Malaria; CRC cis rs10504229 0.683 rs59679713 chr8:58134370 G/C cg22535103 chr8:58192502 C8orf71 -0.69 -9.3 -0.46 2.05e-18 Developmental language disorder (linguistic errors); CRC cis rs2404602 0.692 rs8043474 chr15:76974723 T/C cg23625390 chr15:77176239 SCAPER 0.49 7.23 0.37 3.35e-12 Blood metabolite levels; CRC trans rs208520 0.690 rs851465 chr6:66840293 G/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.08 -14.9 -0.63 9.49e-39 Exhaled nitric oxide output; CRC cis rs6502050 0.749 rs7209948 chr17:80086804 T/G cg22110888 chr17:80059540 CCDC57 -0.41 -6.39 -0.33 5.57e-10 Life satisfaction; CRC cis rs12545109 0.879 rs1975285 chr8:57358682 G/C cg09654669 chr8:57350985 NA -0.43 -5.87 -0.31 1.05e-8 Obesity-related traits; CRC cis rs2479724 0.870 rs7766817 chr6:41918104 T/A cg17623882 chr6:41773611 USP49 -0.52 -8.31 -0.42 2.49e-15 Menarche (age at onset); CRC cis rs12143943 0.902 rs7541449 chr1:204578308 G/T cg17419461 chr1:204415978 PIK3C2B 0.38 5.96 0.31 6.59e-9 Cognitive performance; CRC cis rs34172651 0.517 rs189919 chr16:24737741 G/A cg06028605 chr16:24865363 SLC5A11 -0.54 -8.35 -0.42 1.91e-15 Intelligence (multi-trait analysis); CRC cis rs7538876 0.935 rs6586542 chr1:17763566 C/G cg07965774 chr1:17746286 RCC2 -0.31 -5.8 -0.3 1.55e-8 Basal cell carcinoma; CRC cis rs6564851 0.506 rs11641342 chr16:81257588 G/A cg05274606 chr16:81253692 PKD1L2 -0.35 -5.65 -0.3 3.53e-8 Carotenoid and tocopherol levels; CRC cis rs9747201 0.925 rs7209621 chr17:80057099 C/T cg14673194 chr17:80132900 CCDC57 0.49 6.12 0.32 2.59e-9 Peripheral arterial disease (traffic-related air pollution interaction); CRC trans rs12310956 0.515 rs1405031 chr12:33958931 A/C cg26384229 chr12:38710491 ALG10B 0.46 6.32 0.33 8.5e-10 Morning vs. evening chronotype; CRC cis rs1577917 1.000 rs11758849 chr6:86708262 G/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.54 -6.52 -0.34 2.7e-10 Response to antipsychotic treatment; CRC cis rs9322193 0.962 rs952165 chr6:150120036 T/C cg07701084 chr6:150067640 NUP43 0.47 6.61 0.34 1.51e-10 Lung cancer; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg19767562 chr7:100224437 TFR2 0.42 6.71 0.35 8.74e-11 Liver disease severity in Alagille syndrome; CRC cis rs2230307 0.536 rs580611 chr1:100622925 G/A cg24955406 chr1:100503596 HIAT1 -0.52 -6.31 -0.33 8.83e-10 Carotid intima media thickness; CRC cis rs4820294 1.000 rs41280035 chr22:38054038 A/G cg21798802 chr22:38057573 PDXP 0.43 6.81 0.35 4.74e-11 Fat distribution (HIV); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg01258499 chr20:30540016 PDRG1 0.44 6.25 0.33 1.25e-9 Response to antipsychotic treatment; CRC cis rs7590720 0.819 rs6435931 chr2:216892754 C/G cg25588852 chr2:216877276 MREG -0.31 -5.85 -0.31 1.22e-8 Alcohol dependence; CRC cis rs3106136 0.967 rs767657 chr4:95227901 G/T cg11021082 chr4:95130006 SMARCAD1 -0.46 -6.95 -0.36 1.97e-11 Capecitabine sensitivity; CRC cis rs9467711 0.606 rs34622023 chr6:26362119 A/T cg16898833 chr6:26189333 HIST1H4D 0.75 6.55 0.34 2.26e-10 Autism spectrum disorder or schizophrenia; CRC cis rs7772486 0.790 rs6917482 chr6:146243581 C/T cg23711669 chr6:146136114 FBXO30 -0.72 -12.64 -0.57 3.92e-30 Lobe attachment (rater-scored or self-reported); CRC cis rs6121246 0.559 rs6087782 chr20:30391580 C/T cg13852791 chr20:30311386 BCL2L1 0.8 15.91 0.66 1.15e-42 Mean corpuscular hemoglobin; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg24361620 chr11:45868787 CRY2 0.46 6.83 0.35 4.17e-11 Intelligence (multi-trait analysis); CRC cis rs1941023 0.584 rs4938941 chr11:60173360 C/T cg08716584 chr11:60157161 MS4A7 0.55 9.04 0.45 1.37e-17 Congenital heart disease (maternal effect); CRC cis rs3126085 0.877 rs7537633 chr1:152223333 T/G cg09127314 chr1:152161683 NA 0.46 5.93 0.31 7.69e-9 Atopic dermatitis; CRC trans rs9291683 0.620 rs4444830 chr4:10124819 A/G cg26043149 chr18:55253948 FECH -0.54 -7.7 -0.39 1.63e-13 Bone mineral density; CRC cis rs2257205 0.667 rs9916423 chr17:56773834 T/C cg25885038 chr17:56607967 SEPT4 -0.52 -5.71 -0.3 2.5e-8 Pancreatic cancer; CRC cis rs889312 0.500 rs832585 chr5:56125904 T/C cg12311346 chr5:56204834 C5orf35 -0.47 -7.16 -0.37 5.16e-12 Breast cancer;Breast cancer (early onset); CRC cis rs1448094 0.512 rs12314318 chr12:86249238 T/C cg02569458 chr12:86230093 RASSF9 0.43 7.41 0.38 1.06e-12 Major depressive disorder; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg15312298 chr8:127570908 FAM84B 0.44 6.45 0.34 4.01e-10 Response to antipsychotic treatment; CRC cis rs853679 0.517 rs9368553 chr6:28082265 T/C cg25164649 chr6:28176230 NA 0.77 9.5 0.46 4.6e-19 Depression; CRC trans rs1642645 0.831 rs6600396 chr1:42489534 G/A cg16926213 chr1:1841314 NA -0.43 -6.09 -0.32 3.07e-9 Left ventricular obstructive tract defect (maternal effect); CRC cis rs9443645 0.527 rs12527806 chr6:79507667 A/T cg09184832 chr6:79620586 NA -0.44 -7.7 -0.39 1.5700000000000001e-13 Intelligence (multi-trait analysis); CRC cis rs9378357 0.702 rs4383859 chr6:3280241 C/G cg08754725 chr6:3293098 SLC22A23 0.71 5.66 0.3 3.32e-8 Obesity-related traits; CRC cis rs9400239 0.622 rs2207731 chr6:109013664 C/T cg11073813 chr6:109029018 NA 0.4 6.41 0.33 4.93e-10 Waist circumference;Body mass index;BMI (adjusted for smoking behaviour); CRC cis rs7584330 0.518 rs78856668 chr2:238438055 A/C cg14458575 chr2:238380390 NA 0.8 10.09 0.49 5.06e-21 Prostate cancer; CRC cis rs921968 0.565 rs13412324 chr2:219620521 T/C cg02176678 chr2:219576539 TTLL4 -0.39 -6.31 -0.33 8.83e-10 Mean corpuscular hemoglobin concentration; CRC cis rs1949733 0.701 rs2688222 chr4:8473735 C/A cg11789530 chr4:8429930 ACOX3 0.73 10.44 0.5 3.2e-22 Response to antineoplastic agents; CRC trans rs61931739 0.500 rs7307583 chr12:34521711 T/C cg26384229 chr12:38710491 ALG10B 0.61 9.09 0.45 9.33e-18 Morning vs. evening chronotype; CRC cis rs8077889 0.763 rs4792913 chr17:41854497 T/C cg26893861 chr17:41843967 DUSP3 1.06 20.35 0.75 3.63e-60 Triglycerides; CRC cis rs889398 0.741 rs4146819 chr16:69923563 C/A cg00738113 chr16:70207722 CLEC18C -0.34 -5.81 -0.3 1.49e-8 Body mass index; CRC cis rs1577917 0.958 rs12198876 chr6:86525476 C/A cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.61 -7.57 -0.39 3.78e-13 Response to antipsychotic treatment; CRC cis rs2204008 0.837 rs73112346 chr12:38357606 C/T cg13010199 chr12:38710504 ALG10B 0.45 5.76 0.3 1.96e-8 Bladder cancer; CRC cis rs4713118 0.586 rs9468290 chr6:28087674 C/T cg21251018 chr6:28226885 NKAPL 0.48 6.19 0.32 1.84e-9 Parkinson's disease; CRC cis rs6960043 1.000 rs6962498 chr7:15050305 C/G cg19272540 chr7:15055459 NA -0.22 -5.83 -0.31 1.33e-8 Type 2 diabetes; CRC cis rs2932538 0.883 rs6701351 chr1:113139196 G/A cg22162597 chr1:113214053 CAPZA1 0.61 9.1 0.45 8.58e-18 Systolic blood pressure;Diastolic blood pressure;Hypertension;Blood pressure; CRC cis rs1862618 0.853 rs1423620 chr5:56100996 G/T cg03609598 chr5:56110824 MAP3K1 -0.79 -9.64 -0.47 1.59e-19 Initial pursuit acceleration; CRC cis rs6743376 0.556 rs1530551 chr2:113817566 C/T cg24553058 chr2:113831203 IL1F10 -0.41 -6.62 -0.34 1.5e-10 Inflammatory biomarkers; CRC cis rs4953076 0.573 rs9973609 chr2:44450435 T/C cg04920474 chr2:44395004 PPM1B 0.6 7.59 0.39 3.39e-13 Height; CRC trans rs6546043 0.756 rs6705192 chr2:64137828 C/G cg20306022 chr2:7947960 NA -0.51 -6.02 -0.31 4.6e-9 Clozapine-induced agranulocytosis; CRC cis rs2692947 0.673 rs1168965 chr2:96787899 C/G cg23100626 chr2:96804247 ASTL -0.28 -7.89 -0.4 4.43e-14 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; CRC trans rs2243480 1.000 rs6460274 chr7:65628484 T/A cg10756647 chr7:56101905 PSPH -0.76 -7.89 -0.4 4.47e-14 Diabetic kidney disease; CRC cis rs2014572 0.967 rs8111977 chr19:57759158 T/A cg24459738 chr19:57751996 ZNF805 -0.57 -9.01 -0.44 1.76e-17 Hyperactive-impulsive symptoms; CRC cis rs597539 0.690 rs578791 chr11:68625809 C/T cg06028808 chr11:68637592 NA 0.42 6.69 0.35 9.51e-11 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs13392177 0.672 rs4674270 chr2:219053141 G/T cg04731861 chr2:219085781 ARPC2 0.29 5.83 0.31 1.33e-8 Pyoderma gangrenosum in inflammatory bowel disease; CRC cis rs6748734 1.000 rs6748734 chr2:241837452 A/G cg07537917 chr2:241836409 C2orf54 -0.21 -5.81 -0.3 1.49e-8 Urinary metabolites; CRC cis rs4713675 0.565 rs2281829 chr6:33675642 A/G cg14003231 chr6:33640908 ITPR3 0.51 8.26 0.41 3.71e-15 Plateletcrit; CRC cis rs13217239 0.646 rs6937880 chr6:27000236 C/T cg12292205 chr6:26970375 C6orf41 0.56 9.45 0.46 6.32e-19 Schizophrenia; CRC trans rs1455244 0.700 rs7229302 chr18:11508904 G/T cg26385523 chr19:51611757 CTU1 0.4 6.01 0.31 4.92e-9 Schizophrenia; CRC cis rs11098499 0.754 rs12506610 chr4:120241659 T/C cg24375607 chr4:120327624 NA 0.48 7.61 0.39 2.87e-13 Corneal astigmatism; CRC cis rs10751667 0.621 rs10794353 chr11:948740 A/G ch.11.42038R chr11:967971 AP2A2 0.59 10.18 0.49 2.44e-21 Alzheimer's disease (late onset); CRC cis rs4234798 0.500 rs7661077 chr4:7219889 C/T cg18431297 chr4:7219810 SORCS2 0.76 13.78 0.61 1.96e-34 Insulin-like growth factors; CRC cis rs9868809 0.505 rs11719291 chr3:48735706 A/G cg00383909 chr3:49044727 WDR6 0.77 8.18 0.41 6.4e-15 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; CRC cis rs7605827 0.930 rs6431711 chr2:15683930 G/T cg19274914 chr2:15703543 NA 0.39 5.82 0.31 1.4e-8 Educational attainment (years of education); CRC cis rs3806843 0.735 rs702394 chr5:140086786 A/G cg19875535 chr5:140030758 IK -0.62 -10.41 -0.5 4.14e-22 Depressive symptoms (multi-trait analysis); CRC trans rs4650994 0.625 rs6681348 chr1:178526271 A/C cg05059571 chr16:84539110 KIAA1609 -0.45 -6.84 -0.35 3.76e-11 HDL cholesterol levels;HDL cholesterol; CRC cis rs9910055 0.747 rs2905981 chr17:42238625 C/T cg19774624 chr17:42201019 HDAC5 -0.66 -9.92 -0.48 1.78e-20 Total body bone mineral density; CRC cis rs9522267 0.511 rs4773397 chr13:112245044 T/C cg14352298 chr13:112236639 NA 0.28 6.3 0.33 9.57e-10 Hepatitis; CRC cis rs3096299 0.685 rs2911244 chr16:89521860 A/G cg01788221 chr16:89496183 ANKRD11 -0.41 -6.07 -0.32 3.44e-9 Multiple myeloma (IgH translocation); CRC cis rs4713118 0.523 rs2179096 chr6:27665920 C/T cg12273811 chr6:28175739 NA 0.45 6.52 0.34 2.59e-10 Parkinson's disease; CRC trans rs561341 0.769 rs12941700 chr17:30185022 A/G cg27661571 chr11:113659931 NA 0.68 7.53 0.38 5.08e-13 Hip circumference adjusted for BMI; CRC cis rs7224685 0.569 rs34357603 chr17:4008760 G/A cg05562828 chr17:3906858 NA 0.44 5.64 0.3 3.57e-8 Type 2 diabetes; CRC cis rs9322193 0.567 rs7742692 chr6:150213499 A/G cg13206674 chr6:150067644 NUP43 0.48 6.86 0.35 3.33e-11 Lung cancer; CRC cis rs875971 0.545 rs313830 chr7:65551931 T/C cg02869306 chr7:64672164 INTS4L1 0.44 6.17 0.32 2.02e-9 Aortic root size; CRC cis rs4713118 0.629 rs203890 chr6:28022248 T/C cg25164649 chr6:28176230 NA 0.66 8.75 0.43 1.12e-16 Parkinson's disease; CRC cis rs1552244 0.554 rs3846167 chr3:9996426 T/C cg00166722 chr3:10149974 C3orf24 0.42 6.3 0.33 9.75e-10 Alzheimer's disease; CRC cis rs2243480 1.000 rs1723269 chr7:65472786 C/G cg12463550 chr7:65579703 CRCP 0.67 6.31 0.33 8.99e-10 Diabetic kidney disease; CRC cis rs116095464 0.558 rs10475136 chr5:232796 A/G cg22857025 chr5:266934 NA -1.23 -16.46 -0.67 8.13e-45 Breast cancer; CRC cis rs9399135 0.967 rs4142299 chr6:135377186 G/T cg22676075 chr6:135203613 NA 0.4 6.13 0.32 2.52e-9 Red blood cell count; CRC cis rs1448094 0.872 rs10863146 chr12:86408326 C/G cg18827107 chr12:86230957 RASSF9 -0.37 -5.89 -0.31 9.39e-9 Major depressive disorder; CRC cis rs28386778 0.897 rs2665795 chr17:61925272 A/G cg22520471 chr17:61851767 DDX42;CCDC47 -0.74 -11.68 -0.54 1.29e-26 Prudent dietary pattern; CRC cis rs4975709 0.569 rs2077269 chr5:1863506 C/T cg11168104 chr5:1857477 NA -0.39 -6.78 -0.35 5.53e-11 Cardiovascular disease risk factors; CRC cis rs7044106 0.762 rs1411158 chr9:123464804 A/G cg09586646 chr9:123605570 PSMD5;LOC253039 0.6 8.87 0.44 4.89e-17 Hip circumference adjusted for BMI; CRC cis rs8031584 0.560 rs1056118 chr15:31203786 G/A cg14829155 chr15:31115871 NA 0.37 5.88 0.31 1.02e-8 Huntington's disease progression; CRC cis rs6598955 0.671 rs12068212 chr1:26612935 C/T cg00852783 chr1:26633632 UBXN11 -0.49 -5.81 -0.31 1.45e-8 Obesity-related traits; CRC cis rs2062225 1.000 rs6722913 chr2:111762160 C/T cg11729679 chr2:111877065 BCL2L11 -0.56 -5.62 -0.3 4.08e-8 Monocyte count; CRC cis rs9796 0.561 rs7173086 chr15:41509288 A/T cg18705301 chr15:41695430 NDUFAF1 -0.37 -6.09 -0.32 3.09e-9 Menopause (age at onset); CRC cis rs7605827 0.930 rs7605730 chr2:15598696 A/G cg19274914 chr2:15703543 NA 0.39 5.96 0.31 6.58e-9 Educational attainment (years of education); CRC cis rs1448094 0.511 rs34656916 chr12:86154658 G/C cg18827107 chr12:86230957 RASSF9 -0.41 -6.18 -0.32 1.89e-9 Major depressive disorder; CRC cis rs951366 0.873 rs823118 chr1:205723572 C/T cg11965913 chr1:205819406 PM20D1 0.45 6.87 0.35 3.2e-11 Menarche (age at onset); CRC cis rs10078 0.515 rs1053299 chr5:470760 G/A cg24955955 chr5:415729 AHRR 0.64 6.18 0.32 1.86e-9 Fat distribution (HIV); CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg03157738 chr19:11308118 KANK2 0.47 6.04 0.32 4.08e-9 Thyroid stimulating hormone; CRC cis rs7806994 1 rs7806994 chr7:56139505 A/T cg21096502 chr7:56174374 CHCHD2 -0.65 -6.84 -0.35 3.98e-11 PR interval in Tripanosoma cruzi seropositivity; CRC cis rs11971779 0.680 rs10273527 chr7:139036598 A/C cg23387468 chr7:139079360 LUC7L2 -0.41 -7.28 -0.37 2.56e-12 Diisocyanate-induced asthma; CRC cis rs17376456 0.877 rs10044139 chr5:93407803 T/C cg09848695 chr5:92956644 FAM172A;MIR2277 0.61 5.68 0.3 2.95e-8 Diabetic retinopathy; CRC cis rs1712517 0.771 rs11191645 chr10:105059308 G/T cg05636881 chr10:105038444 INA 0.45 7.84 0.4 6.43e-14 Migraine; CRC cis rs2243480 0.803 rs36127118 chr7:65565505 A/G cg18252515 chr7:66147081 NA -1.14 -13.85 -0.61 1.06e-34 Diabetic kidney disease; CRC cis rs910316 1.000 rs12889472 chr14:75543979 A/G cg03030879 chr14:75389066 RPS6KL1 -0.44 -6.79 -0.35 5.21e-11 Height; CRC cis rs2739330 0.760 rs5760095 chr22:24247293 A/G cg23131131 chr22:24373011 LOC391322 -0.64 -9.67 -0.47 1.24e-19 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs798554 0.660 rs2527692 chr7:2856533 G/A cg17321639 chr7:2759063 NA -0.42 -6.45 -0.34 3.94e-10 Height; CRC cis rs3540 0.960 rs8040585 chr15:91026477 T/C cg04176472 chr15:90893244 GABARAPL3 0.35 6.05 0.32 4.02e-9 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; CRC cis rs8077889 0.826 rs60085355 chr17:41847415 T/C cg16892393 chr17:41919603 NA 0.39 5.9 0.31 8.88e-9 Triglycerides; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg14684917 chr11:62380363 EML3;ROM1 0.4 7.15 0.37 5.73e-12 Liver disease severity in Alagille syndrome; CRC cis rs4665809 0.590 rs6749046 chr2:26429451 C/G cg22920501 chr2:26401640 FAM59B 0.86 12.56 0.57 8.21e-30 Gut microbiome composition (summer); CRC cis rs6076065 0.723 rs2424544 chr20:23390314 C/T cg11657817 chr20:23433608 CST11 0.43 6.34 0.33 7.77e-10 Facial morphology (factor 15, philtrum width); CRC cis rs1153858 1.000 rs12440038 chr15:45706739 A/G cg21132104 chr15:45694354 SPATA5L1 0.6 8.54 0.43 4.93e-16 Homoarginine levels; CRC cis rs4481887 0.597 rs11488132 chr1:248542353 A/G cg00666640 chr1:248458726 OR2T12 0.5 7.4 0.38 1.14e-12 Common traits (Other); CRC cis rs1129187 1.000 rs1129187 chr6:42932200 G/T cg02359409 chr6:42947317 PEX6 -0.57 -8.86 -0.44 5.05e-17 Alzheimer's disease in APOE e4+ carriers; CRC cis rs2032447 0.714 rs175319 chr6:25956172 A/G cg15691649 chr6:25882328 NA -0.44 -5.9 -0.31 8.99e-9 Intelligence (multi-trait analysis); CRC cis rs3096299 0.503 rs9925045 chr16:89556476 T/C cg02187348 chr16:89574699 SPG7 0.4 5.83 0.31 1.35e-8 Multiple myeloma (IgH translocation); CRC cis rs9649213 0.593 rs736753 chr7:97931489 G/T cg00277769 chr7:97922759 BAIAP2L1 -0.61 -10.74 -0.51 2.85e-23 Prostate cancer (SNP x SNP interaction); CRC cis rs17253792 0.822 rs10147688 chr14:56054642 T/C cg01858014 chr14:56050164 KTN1 -0.88 -7.83 -0.4 6.57e-14 Putamen volume; CRC trans rs1005277 0.557 rs1854563 chr10:38434961 G/A cg11292332 chr7:45801988 SEPT13 -0.35 -6.22 -0.32 1.51e-9 Extrinsic epigenetic age acceleration; CRC cis rs832540 0.656 rs832573 chr5:56159578 T/C cg03609598 chr5:56110824 MAP3K1 -0.43 -5.66 -0.3 3.31e-8 Coronary artery disease; CRC cis rs10927875 0.615 rs10927886 chr1:16339313 C/G cg24140574 chr1:16342155 HSPB7 -0.47 -6.73 -0.35 7.61e-11 Dilated cardiomyopathy; CRC trans rs4689592 0.523 rs6446565 chr4:7074027 A/G cg07817883 chr1:32538562 TMEM39B -0.62 -8.06 -0.41 1.46e-14 Monocyte percentage of white cells; CRC trans rs1005277 0.522 rs1208681 chr10:38092975 C/T cg17830980 chr10:43048298 ZNF37B -0.39 -6.03 -0.32 4.5e-9 Extrinsic epigenetic age acceleration; CRC trans rs208520 0.526 rs6455072 chr6:66797215 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.17 -25.99 -0.82 9.95e-82 Exhaled nitric oxide output; CRC cis rs3785574 0.745 rs2854162 chr17:61975610 T/C cg06873352 chr17:61820015 STRADA -0.46 -6.98 -0.36 1.67e-11 Height; CRC cis rs514406 0.584 rs7524702 chr1:53197830 G/A cg24675658 chr1:53192096 ZYG11B 0.68 10.5 0.5 1.88e-22 Monocyte count; CRC cis rs826838 0.510 rs10506129 chr12:39224242 A/T cg26384229 chr12:38710491 ALG10B 0.56 6.78 0.35 5.54e-11 Heart rate; CRC cis rs79349575 0.685 rs1124829 chr17:46967797 C/A cg22482690 chr17:47019901 SNF8 0.48 8.18 0.41 6.13e-15 Type 2 diabetes; CRC cis rs9894429 0.966 rs6565605 chr17:79589359 C/T cg21984481 chr17:79567631 NPLOC4 -0.52 -9.62 -0.47 1.88e-19 Eye color traits; CRC cis rs11785400 0.793 rs13248524 chr8:143739343 T/C cg10596483 chr8:143751796 JRK 0.43 5.77 0.3 1.8e-8 Schizophrenia; CRC cis rs7524258 0.868 rs4908448 chr1:7269283 A/G cg07173049 chr1:7289937 CAMTA1 -0.44 -7.08 -0.36 8.8e-12 Tourette's syndrome or obsessive-compulsive disorder; CRC cis rs68170813 0.559 rs77641084 chr7:106970522 G/A cg02696742 chr7:106810147 HBP1 -0.56 -6.0 -0.31 5.2e-9 Coronary artery disease; CRC cis rs950169 0.579 rs12913054 chr15:84664456 A/G cg11189052 chr15:85197271 WDR73 0.56 7.45 0.38 8.13e-13 Schizophrenia; CRC cis rs2404602 0.647 rs12904149 chr15:77043652 A/C cg03037974 chr15:76606532 NA -0.54 -7.78 -0.39 9.15e-14 Blood metabolite levels; CRC cis rs7923609 0.846 rs10740115 chr10:65094990 G/A cg08743896 chr10:65200160 JMJD1C -0.4 -5.77 -0.3 1.81e-8 Educational attainment;Liver enzyme levels (alkaline phosphatase); CRC cis rs2836974 0.605 rs2836971 chr21:40652040 A/C cg06238570 chr21:40685208 BRWD1 -0.81 -12.91 -0.58 4.11e-31 Cognitive function; CRC cis rs1577917 0.816 rs1838952 chr6:86601144 G/A cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.46 -5.98 -0.31 5.87e-9 Response to antipsychotic treatment; CRC cis rs8141529 0.664 rs5762862 chr22:29252732 C/T cg15103426 chr22:29168792 CCDC117 0.47 6.17 0.32 2.05e-9 Lymphocyte counts; CRC cis rs6963495 0.818 rs73192107 chr7:105168095 G/A cg02135003 chr7:105160482 PUS7 -0.92 -12.46 -0.57 1.94e-29 Bipolar disorder (body mass index interaction); CRC cis rs7586879 0.598 rs6724772 chr2:25128730 T/C cg04586622 chr2:25135609 ADCY3 -0.54 -10.01 -0.48 8.89e-21 Body mass index; CRC cis rs10256972 0.684 rs2363279 chr7:1096143 A/G cg04025307 chr7:1156635 C7orf50 0.56 8.61 0.43 3.11e-16 Longevity;Endometriosis; CRC cis rs8177253 0.507 rs4241357 chr3:133475563 A/C cg24879335 chr3:133465180 TF -0.35 -6.78 -0.35 5.45e-11 Iron status biomarkers; CRC cis rs7258465 0.965 rs7254249 chr19:18591745 G/A cg10790698 chr19:18539756 SSBP4 -0.45 -8.69 -0.43 1.69e-16 Breast cancer; CRC cis rs12476592 0.602 rs7576316 chr2:63741122 G/A cg10828910 chr2:63850056 LOC388955 0.48 5.99 0.31 5.45e-9 Childhood ear infection; CRC cis rs10463316 0.894 rs7708499 chr5:150765906 A/C cg03212797 chr5:150827313 SLC36A1 -0.49 -7.7 -0.39 1.6e-13 Metabolite levels (Pyroglutamine); CRC trans rs8124695 0.504 rs980356 chr20:38992538 G/A cg12409982 chr3:137489312 NA -0.47 -6.08 -0.32 3.31e-9 Dupuytren's disease; CRC cis rs4953076 0.573 rs6726680 chr2:44406686 C/G cg04920474 chr2:44395004 PPM1B 0.56 7.64 0.39 2.46e-13 Height; CRC cis rs28386778 0.897 rs2137144 chr17:61805607 G/A cg11494091 chr17:61959527 GH2 0.59 9.92 0.48 1.82e-20 Prudent dietary pattern; CRC cis rs3820068 0.603 rs16851884 chr1:15961871 A/G cg27534772 chr1:16042836 PLEKHM2 0.55 10.93 0.52 6.22e-24 Systolic blood pressure; CRC cis rs6499255 0.951 rs60099379 chr16:69582104 A/G cg04110750 chr16:69646130 NFAT5 -0.57 -7.72 -0.39 1.4e-13 IgE levels; CRC cis rs8072100 0.905 rs9895274 chr17:45539117 C/T cg08085267 chr17:45401833 C17orf57 -0.72 -12.09 -0.55 4.16e-28 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs4713118 0.513 rs149958 chr6:28013617 A/C cg15786705 chr6:28176104 NA 0.58 8.22 0.41 4.65e-15 Parkinson's disease; CRC cis rs12368653 0.525 rs1564374 chr12:58010163 C/T cg00700412 chr12:58011837 NA 0.48 7.75 0.39 1.14e-13 Multiple sclerosis; CRC cis rs10751667 0.600 rs11246377 chr11:999796 G/T cg23136738 chr11:925521 AP2A2 -0.41 -6.61 -0.34 1.59e-10 Alzheimer's disease (late onset); CRC cis rs7811142 1.000 rs4463351 chr7:100078226 G/A cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.08 15.27 0.64 3.58e-40 Platelet count; CRC cis rs4474465 0.920 rs7113559 chr11:78205703 T/G cg27205649 chr11:78285834 NARS2 0.48 5.87 0.31 1.05e-8 Alzheimer's disease (survival time); CRC cis rs9522267 0.535 rs12583489 chr13:112233455 G/A cg26182253 chr13:112236782 NA 0.31 6.29 0.33 9.96e-10 Hepatitis; CRC cis rs1707322 1.000 rs4539075 chr1:46358010 C/T cg06784218 chr1:46089804 CCDC17 0.52 9.08 0.45 1.05e-17 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs9487051 0.872 rs9386790 chr6:109608460 G/T cg01475377 chr6:109611718 NA 0.48 9.02 0.45 1.63e-17 Reticulocyte fraction of red cells; CRC cis rs798554 0.757 rs1182198 chr7:2862906 C/T cg04166393 chr7:2884313 GNA12 0.54 7.1 0.36 7.65e-12 Height; CRC cis rs2404602 0.583 rs12438741 chr15:76542114 C/A cg22467129 chr15:76604101 ETFA -0.49 -8.58 -0.43 3.93e-16 Blood metabolite levels; CRC cis rs34779708 0.702 rs4244995 chr10:35547175 A/G cg03585969 chr10:35415529 CREM 0.52 6.79 0.35 5.37e-11 Inflammatory bowel disease;Crohn's disease; CRC cis rs11148252 0.875 rs9526913 chr13:52975837 T/C cg12458913 chr13:53173898 NA 0.51 7.96 0.4 2.82e-14 Lewy body disease; CRC cis rs1506636 0.962 rs10273985 chr7:123309538 A/T cg03229431 chr7:123269106 ASB15 -0.75 -12.09 -0.55 4.23e-28 Plateletcrit;Platelet count; CRC cis rs2315504 0.509 rs3760335 chr17:39026061 T/A cg05063374 chr17:38953512 KRT28 -0.37 -5.64 -0.3 3.71e-8 Height; CRC cis rs9942416 0.660 rs66493518 chr5:74990125 G/C cg00601450 chr5:74908170 NA 0.42 5.83 0.31 1.34e-8 Age-related disease endophenotypes; CRC cis rs13256369 0.760 rs7839473 chr8:8575836 C/T cg00074818 chr8:8560427 CLDN23 0.34 6.23 0.32 1.42e-9 Obesity-related traits; CRC cis rs9287719 0.967 rs10191883 chr2:10744136 A/G cg00105475 chr2:10696890 NA 0.45 7.3 0.37 2.2e-12 Prostate cancer; CRC cis rs7659604 0.539 rs7660548 chr4:122730821 G/C cg23574427 chr4:122746245 BBS7;CCNA2 -0.3 -5.65 -0.3 3.39e-8 Type 2 diabetes; CRC cis rs6598955 0.666 rs12759434 chr1:26607123 C/T cg00852783 chr1:26633632 UBXN11 0.42 6.82 0.35 4.28e-11 Obesity-related traits; CRC trans rs9858542 0.953 rs9878943 chr3:49434654 G/A cg21582582 chr3:182698605 DCUN1D1 -0.52 -6.65 -0.34 1.22e-10 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs7726839 0.540 rs4957080 chr5:644552 A/C cg16447950 chr5:562315 NA 0.74 9.71 0.47 9.02e-20 Obesity-related traits; CRC cis rs68170813 0.559 rs80212020 chr7:106957596 C/T cg02696742 chr7:106810147 HBP1 -0.59 -6.54 -0.34 2.29e-10 Coronary artery disease; CRC cis rs1707322 1.000 rs785517 chr1:46567535 A/T cg06784218 chr1:46089804 CCDC17 -0.6 -10.53 -0.5 1.56e-22 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs6701037 1.000 rs6659824 chr1:175125378 C/A cg00321850 chr1:175162397 KIAA0040 -0.36 -5.9 -0.31 8.95e-9 Alcohol dependence; CRC cis rs72781680 0.898 rs12619525 chr2:23999565 G/C cg08917208 chr2:24149416 ATAD2B 0.86 8.35 0.42 1.86e-15 Lymphocyte counts; CRC cis rs1448094 0.511 rs10863080 chr12:86153149 C/T cg19622623 chr12:86230825 RASSF9 0.38 5.81 0.31 1.46e-8 Major depressive disorder; CRC cis rs1401999 1.000 rs6443924 chr3:183679532 A/G cg01324343 chr3:183735012 ABCC5 0.79 14.39 0.62 8.91e-37 Anterior chamber depth; CRC cis rs9660180 0.967 rs10907191 chr1:1774820 A/T cg13866156 chr1:1669148 SLC35E2 -0.63 -9.46 -0.46 5.93e-19 Body mass index; CRC cis rs883565 0.528 rs9311200 chr3:38953896 C/T cg01426195 chr3:39028469 NA -0.37 -6.18 -0.32 1.92e-9 Handedness; CRC cis rs2075371 0.863 rs9641966 chr7:133961205 G/A cg20476274 chr7:133979776 SLC35B4 0.72 11.95 0.55 1.38e-27 Mean platelet volume; CRC cis rs1965732 0.522 rs34086816 chr2:3718985 A/G cg19052272 chr2:3704530 ALLC -0.41 -5.64 -0.3 3.62e-8 Response to inhaled corticosteroid treatment in asthma (change in FEV1); CRC cis rs4481887 1.000 rs9660769 chr1:248484558 C/G cg00666640 chr1:248458726 OR2T12 -0.56 -9.89 -0.48 2.39e-20 Common traits (Other); CRC cis rs951366 0.789 rs823110 chr1:205701078 G/C cg17178900 chr1:205818956 PM20D1 0.67 9.85 0.48 3.24e-20 Menarche (age at onset); CRC cis rs1784581 0.651 rs1784588 chr6:162390027 T/A cg17173639 chr6:162384350 PARK2 -0.71 -12.05 -0.55 5.91e-28 Itch intensity from mosquito bite; CRC trans rs9291683 0.588 rs3756238 chr4:10013202 C/T cg26043149 chr18:55253948 FECH 0.51 7.91 0.4 3.95e-14 Bone mineral density; CRC cis rs992157 0.731 rs1399132 chr2:219159770 G/A cg00012203 chr2:219082015 ARPC2 0.45 6.88 0.35 2.99e-11 Colorectal cancer; CRC cis rs1008375 0.966 rs6449330 chr4:17703949 C/T cg16339924 chr4:17578868 LAP3 -0.48 -6.25 -0.33 1.3e-9 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs9486715 0.867 rs11152924 chr6:96877383 A/G cg18709589 chr6:96969512 KIAA0776 0.47 7.01 0.36 1.34e-11 Headache; CRC cis rs4713118 0.868 rs35069907 chr6:27746692 T/C cg12172441 chr6:28176163 NA 0.57 6.25 0.33 1.25e-9 Parkinson's disease; CRC cis rs9322193 0.923 rs10782316 chr6:150073891 A/C cg00933542 chr6:150070202 PCMT1 0.33 6.97 0.36 1.73e-11 Lung cancer; CRC cis rs9733 0.536 rs6661415 chr1:150635869 G/A cg10589385 chr1:150898437 SETDB1 0.28 5.94 0.31 7.24e-9 Tonsillectomy; CRC cis rs4665809 0.590 rs35727620 chr2:26458364 G/A cg22920501 chr2:26401640 FAM59B 0.83 11.96 0.55 1.28e-27 Gut microbiome composition (summer); CRC cis rs73200209 0.626 rs55984419 chr12:116578042 G/A cg01776926 chr12:116560359 MED13L -0.57 -6.28 -0.33 1.06e-9 Total body bone mineral density; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg01151424 chr11:17411006 KCNJ11 0.42 6.32 0.33 8.44e-10 Intelligence (multi-trait analysis); CRC cis rs56307353 0.652 rs4807191 chr19:1990309 C/T cg26776924 chr19:1969666 CSNK1G2 -0.44 -7.05 -0.36 1.09e-11 Coronary artery disease; CRC cis rs3091242 0.933 rs28633797 chr1:25741629 C/A cg27572855 chr1:25598939 RHD 0.36 6.25 0.33 1.24e-9 Erythrocyte sedimentation rate; CRC cis rs644799 0.965 rs565771 chr11:95644179 T/A cg25478527 chr11:95522999 CEP57;FAM76B 0.5 7.34 0.38 1.65e-12 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs5751150 1 rs5751150 chr22:42153292 T/G cg03806693 chr22:41940476 POLR3H 1.09 13.45 0.6 3.5e-33 Cannabis dependence symptom count; CRC cis rs7618915 0.547 rs11130315 chr3:52697163 A/G cg15147215 chr3:52552868 STAB1 -0.63 -10.4 -0.5 4.44e-22 Bipolar disorder; CRC cis rs1801251 1.000 rs2675971 chr2:233726154 A/G cg25237894 chr2:233734115 C2orf82 -0.53 -8.43 -0.42 1.13e-15 Coronary artery disease; CRC cis rs1799949 1.000 rs4793197 chr17:41231902 C/T cg23758822 chr17:41437982 NA 0.82 13.78 0.6 2.04e-34 Menopause (age at onset); CRC cis rs6938 0.596 rs11630918 chr15:75155896 C/T cg05627522 chr15:75251581 NA 0.38 5.87 0.31 1.08e-8 Breast cancer; CRC cis rs7147624 1.000 rs2411354 chr14:66062132 T/C cg03016385 chr14:66212404 NA -1.05 -10.86 -0.51 1.12e-23 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs6504622 0.905 rs736603 chr17:45024745 G/T cg16759221 chr17:45003025 GOSR2 -0.54 -8.46 -0.42 8.86e-16 Orofacial clefts; CRC cis rs2842992 0.789 rs6908680 chr6:160218209 G/T cg16489826 chr6:160211363 TCP1;MRPL18 0.5 6.22 0.32 1.47e-9 Age-related macular degeneration (geographic atrophy); CRC cis rs11190604 0.790 rs11190535 chr10:102197441 A/T cg07080220 chr10:102295463 HIF1AN 0.48 5.93 0.31 7.86e-9 Palmitoleic acid (16:1n-7) levels; CRC cis rs11122272 0.735 rs2250734 chr1:231485958 G/A cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.54 -8.25 -0.41 3.74e-15 Hemoglobin concentration; CRC cis rs1448094 0.692 rs7958438 chr12:86326141 A/T cg25456477 chr12:86230367 RASSF9 0.34 5.86 0.31 1.1e-8 Major depressive disorder; CRC cis rs35306767 0.903 rs12264711 chr10:929525 T/C cg26597838 chr10:835615 NA 0.97 11.95 0.55 1.36e-27 Eosinophil percentage of granulocytes; CRC cis rs9372498 0.536 rs62424172 chr6:118777533 C/A cg15382696 chr6:118971807 C6orf204 0.59 7.5 0.38 6.18e-13 Diastolic blood pressure; CRC cis rs7746199 0.736 rs17693963 chr6:27710165 A/C cg23372001 chr6:27791640 HIST1H4J 0.83 5.61 0.3 4.28e-8 Gait speed in old age;Autism spectrum disorder or schizophrenia; CRC cis rs728616 1.000 rs56317427 chr10:81861934 T/C cg05935833 chr10:81318306 SFTPA2 -0.55 -6.54 -0.34 2.29e-10 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs7909074 1.000 rs1408814 chr10:45399088 A/G cg05187965 chr10:45406764 TMEM72 -0.37 -8.36 -0.42 1.8e-15 Mean corpuscular volume; CRC cis rs826838 0.967 rs11169142 chr12:39085773 A/T cg26384229 chr12:38710491 ALG10B -0.61 -9.58 -0.47 2.49e-19 Heart rate; CRC cis rs2576037 0.583 rs501882 chr18:44411066 A/T cg19077165 chr18:44547161 KATNAL2 -0.6 -9.71 -0.47 9.1e-20 Personality dimensions; CRC cis rs208520 0.909 rs58958359 chr6:67021381 A/C cg07460842 chr6:66804631 NA 0.84 9.91 0.48 1.91e-20 Exhaled nitric oxide output; CRC cis rs2204008 0.540 rs3908193 chr12:38410907 G/T cg26384229 chr12:38710491 ALG10B -0.52 -7.54 -0.38 4.7e-13 Bladder cancer; CRC cis rs35123781 1.000 rs601728 chr5:139057076 T/C cg10513866 chr5:139070639 NA 0.48 7.45 0.38 8.42e-13 Schizophrenia; CRC cis rs2758596 0.850 rs2241110 chr1:156172487 A/G cg25208724 chr1:156163844 SLC25A44 0.71 7.02 0.36 1.29e-11 Paclitaxel disposition in epithelial ovarian cancer; CRC cis rs2032447 0.867 rs9295683 chr6:26069495 C/T cg18357526 chr6:26021779 HIST1H4A 0.7 10.97 0.52 4.62e-24 Intelligence (multi-trait analysis); CRC cis rs758324 0.947 rs924434 chr5:131143369 A/C cg06307176 chr5:131281290 NA 0.43 6.29 0.33 1e-9 Alzheimer's disease in APOE e4- carriers; CRC cis rs4713118 0.621 rs9295755 chr6:28033174 C/T cg03623178 chr6:28175578 NA -0.86 -11.39 -0.53 1.49e-25 Parkinson's disease; CRC cis rs2415984 0.562 rs12895104 chr14:46972736 G/A cg14871534 chr14:47121158 RPL10L 0.41 5.75 0.3 2.03e-8 Number of children ever born; CRC cis rs2573652 0.722 rs11636047 chr15:100543341 A/G cg00587665 chr15:100533223 ADAMTS17 -0.39 -6.83 -0.35 4.2e-11 Height; CRC cis rs11587400 0.679 rs6537836 chr1:115108923 T/C cg12756093 chr1:115239321 AMPD1 0.43 5.9 0.31 9.27e-9 Autism; CRC cis rs9910055 0.529 rs170637 chr17:42186868 C/T cg13607699 chr17:42295918 UBTF -0.53 -6.93 -0.36 2.29e-11 Total body bone mineral density; CRC cis rs11098499 0.954 rs7437420 chr4:120312903 A/G cg09307838 chr4:120376055 NA 0.7 10.82 0.51 1.47e-23 Corneal astigmatism; CRC cis rs6502050 0.835 rs35857672 chr17:80078303 G/A cg22110888 chr17:80059540 CCDC57 -0.41 -6.44 -0.33 4.12e-10 Life satisfaction; CRC cis rs4713118 0.547 rs2116981 chr6:28067951 T/G cg18032046 chr6:28092343 ZSCAN16 -0.5 -5.89 -0.31 9.34e-9 Parkinson's disease; CRC cis rs11098499 0.955 rs1511018 chr4:120161580 G/T cg09307838 chr4:120376055 NA 0.63 9.67 0.47 1.21e-19 Corneal astigmatism; CRC cis rs910873 0.505 rs6087607 chr20:33197489 A/G cg08999081 chr20:33150536 PIGU 0.5 6.19 0.32 1.75e-9 Melanoma; CRC cis rs2046867 0.908 rs62251650 chr3:72809823 T/C cg25664220 chr3:72788482 NA -0.45 -6.37 -0.33 6.34e-10 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; CRC cis rs1008375 1.000 rs60178264 chr4:17685308 G/T cg16339924 chr4:17578868 LAP3 0.53 7.2 0.37 4.23e-12 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs7772486 0.875 rs9322045 chr6:146384950 C/G cg13319975 chr6:146136371 FBXO30 -0.38 -5.79 -0.3 1.67e-8 Lobe attachment (rater-scored or self-reported); CRC cis rs9875589 0.509 rs4685051 chr3:13981760 A/G cg14375111 chr3:14165186 TMEM43;CHCHD4 0.41 6.06 0.32 3.71e-9 Ovarian reserve; CRC cis rs7937682 0.924 rs6589244 chr11:111534333 T/C cg19812747 chr11:111475976 SIK2 -0.56 -9.45 -0.46 6.39e-19 Primary sclerosing cholangitis; CRC trans rs1005277 0.683 rs7923868 chr10:37989766 T/C cg17830980 chr10:43048298 ZNF37B -0.39 -6.06 -0.32 3.77e-9 Extrinsic epigenetic age acceleration; CRC trans rs7267979 1.000 rs6050555 chr20:25328543 A/G cg17903999 chr18:56338584 MALT1 0.42 6.89 0.36 2.81e-11 Liver enzyme levels (alkaline phosphatase); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg13773948 chr10:43277913 BMS1 0.38 6.22 0.32 1.5e-9 Liver disease severity in Alagille syndrome; CRC cis rs6963495 0.538 rs55967123 chr7:105163678 C/A cg13798780 chr7:105162888 PUS7 0.68 8.08 0.41 1.27e-14 Bipolar disorder (body mass index interaction); CRC cis rs4920343 0.698 rs578988 chr1:19077291 T/C cg19637330 chr1:19110922 NA 0.39 5.87 0.31 1.09e-8 Knee osteoarthritis; CRC cis rs2836950 0.501 rs4818019 chr21:40694456 T/A cg11644478 chr21:40555479 PSMG1 -0.44 -6.49 -0.34 3.07e-10 Menarche (age at onset); CRC cis rs2976388 0.590 rs11785290 chr8:143814849 A/G cg15511327 chr8:143859410 LYNX1 -0.4 -6.68 -0.35 9.91e-11 Urinary tract infection frequency; CRC cis rs7949030 0.591 rs12049914 chr11:62369436 C/G cg22862634 chr11:62369728 EML3;MTA2 0.57 9.96 0.48 1.32e-20 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; CRC cis rs1451375 1.000 rs2329340 chr7:50620229 C/T cg14593290 chr7:50529359 DDC 0.57 7.89 0.4 4.57e-14 Malaria; CRC cis rs9902453 0.817 rs2729449 chr17:28089751 T/C cg26525008 chr17:28256777 EFCAB5;SSH2 -0.57 -8.66 -0.43 2.1e-16 Coffee consumption (cups per day); CRC cis rs11758351 0.660 rs11757754 chr6:26219744 A/C cg01420254 chr6:26195488 NA 0.77 8.59 0.43 3.61e-16 Gout;Renal underexcretion gout; CRC cis rs561341 0.769 rs12941700 chr17:30185022 A/G cg00745463 chr17:30367425 LRRC37B 0.71 7.67 0.39 2.01e-13 Hip circumference adjusted for BMI; CRC cis rs6951245 1.000 rs78143408 chr7:1096846 G/A cg26224354 chr7:1096374 C7orf50;GPR146 -0.93 -12.11 -0.56 3.59e-28 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs10927875 0.550 rs12121918 chr1:16183556 C/A cg21385522 chr1:16154831 NA -0.82 -9.93 -0.48 1.72e-20 Dilated cardiomyopathy; CRC cis rs4731207 0.596 rs6967707 chr7:124609355 G/A cg23710748 chr7:124431027 NA -0.39 -6.23 -0.32 1.46e-9 Cutaneous malignant melanoma; CRC trans rs2303319 0.504 rs12469052 chr2:162319353 T/C cg04145477 chr6:107077629 RTN4IP1;QRSL1 -0.84 -6.27 -0.33 1.13e-9 Cognitive function; CRC cis rs3862030 0.839 rs7078511 chr10:104283874 C/A cg11453585 chr10:104263688 ACTR1A;SUFU -0.77 -13.4 -0.59 5.88e-33 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for body mass index; CRC cis rs3823572 0.525 rs7785128 chr7:133684991 T/C cg03336402 chr7:133662267 EXOC4 -0.63 -9.22 -0.45 3.74e-18 Intelligence (multi-trait analysis); CRC cis rs28386778 0.863 rs9207 chr17:61823899 C/T cg00280220 chr17:61926910 NA 0.33 5.64 0.3 3.66e-8 Prudent dietary pattern; CRC cis rs10504229 1.000 rs72650892 chr8:58179714 A/G cg02290350 chr8:58132656 NA -0.42 -5.96 -0.31 6.62e-9 Developmental language disorder (linguistic errors); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg01080592 chr19:36248739 HSPB6;C19orf55 0.45 6.29 0.33 1.02e-9 Intelligence (multi-trait analysis); CRC cis rs4862750 0.914 rs6814259 chr4:187872337 T/C cg22105103 chr4:187893119 NA 0.63 11.4 0.53 1.32e-25 Lobe attachment (rater-scored or self-reported); CRC cis rs6570726 0.791 rs383841 chr6:145888329 G/T cg23711669 chr6:146136114 FBXO30 -0.76 -13.3 -0.59 1.38e-32 Lobe attachment (rater-scored or self-reported); CRC cis rs56399783 0.614 rs11772508 chr7:2771504 A/C cg19731401 chr7:2775893 GNA12 -0.62 -6.51 -0.34 2.86e-10 Childhood ear infection; CRC cis rs7618915 0.547 rs34173654 chr3:52634605 T/C cg08222913 chr3:52553049 STAB1 -0.34 -6.17 -0.32 1.98e-9 Bipolar disorder; CRC cis rs2842992 0.750 rs2758354 chr6:160125854 A/G cg11366901 chr6:160182831 ACAT2 0.92 12.26 0.56 1.06e-28 Age-related macular degeneration (geographic atrophy); CRC cis rs2180341 0.960 rs9398839 chr6:127665863 G/A cg27446573 chr6:127587934 RNF146 1.0 14.15 0.62 7.94e-36 Breast cancer; CRC cis rs2153535 0.601 rs7775274 chr6:8530303 A/G cg21535247 chr6:8435926 SLC35B3 0.49 7.47 0.38 7.44e-13 Motion sickness; CRC trans rs11098499 0.821 rs10032151 chr4:120391628 C/T cg25214090 chr10:38739885 LOC399744 0.66 10.6 0.5 9.01e-23 Corneal astigmatism; CRC cis rs10504229 0.683 rs72649187 chr8:58108320 A/G cg02725872 chr8:58115012 NA -0.66 -11.36 -0.53 1.84e-25 Developmental language disorder (linguistic errors); CRC cis rs9733 0.596 rs72702580 chr1:150691285 A/T cg17724175 chr1:150552817 MCL1 0.57 9.12 0.45 7.76e-18 Tonsillectomy; CRC cis rs1008375 0.931 rs6449328 chr4:17700474 C/T cg16339924 chr4:17578868 LAP3 0.48 6.18 0.32 1.94e-9 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs1878931 0.624 rs28089 chr16:3446937 G/A cg26668626 chr16:3451006 ZNF174;ZNF434 -0.62 -6.99 -0.36 1.53e-11 Body mass index (adult); CRC cis rs11997175 0.624 rs17700425 chr8:33691467 T/G ch.8.33884649F chr8:33765107 NA 0.43 6.17 0.32 1.95e-9 Body mass index; CRC cis rs3091242 1.000 rs646867 chr1:25709258 A/C cg27572855 chr1:25598939 RHD 0.36 6.36 0.33 6.65e-10 Erythrocyte sedimentation rate; CRC cis rs3815700 1.000 rs8113165 chr19:33096316 C/T cg02997394 chr19:33096574 ANKRD27 0.76 9.07 0.45 1.11e-17 Eosinophilic esophagitis; CRC cis rs13096480 0.583 rs17598137 chr3:49891362 G/T cg24267428 chr3:50649269 CISH 0.37 5.64 0.3 3.75e-8 Intelligence (multi-trait analysis); CRC cis rs1577917 0.917 rs4098044 chr6:86462066 T/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.52 -6.93 -0.36 2.22e-11 Response to antipsychotic treatment; CRC cis rs6988636 1.000 rs28670850 chr8:124189125 A/G cg27053337 chr8:124217698 FAM83A 0.46 6.99 0.36 1.58e-11 Urinary uromodulin levels; CRC cis rs6539288 0.500 rs11113116 chr12:107195929 C/A cg13491945 chr12:107078410 RFX4 0.35 5.97 0.31 6.1e-9 Total body bone mineral density; CRC cis rs2404602 0.583 rs2456076 chr15:76557553 T/G cg22467129 chr15:76604101 ETFA 0.48 8.51 0.42 6.09e-16 Blood metabolite levels; CRC cis rs9910055 0.659 rs3826412 chr17:42255097 A/G cg16434002 chr17:42200994 HDAC5 -0.54 -7.88 -0.4 4.75e-14 Total body bone mineral density; CRC cis rs7131987 0.675 rs3847678 chr12:29551560 A/C cg09582351 chr12:29534625 ERGIC2 0.31 6.76 0.35 6.4e-11 QT interval; CRC cis rs9372498 0.536 rs12333080 chr6:118845410 A/C cg10217327 chr6:118973057 C6orf204 0.51 5.78 0.3 1.73e-8 Diastolic blood pressure; CRC cis rs801193 0.904 rs4718405 chr7:66254646 A/G cg11764359 chr7:65958608 NA 0.5 7.89 0.4 4.51e-14 Aortic root size; CRC cis rs4076764 1.000 rs7528020 chr1:163426537 G/A cg24596788 chr1:163392923 NA -0.63 -10.03 -0.48 7.75e-21 Motion sickness; CRC cis rs8014204 0.816 rs10144023 chr14:75291531 T/C cg03030879 chr14:75389066 RPS6KL1 -0.41 -6.42 -0.33 4.88e-10 Caffeine consumption; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg10620100 chr15:40714174 NA 0.48 7.09 0.36 8.16e-12 Intelligence (multi-trait analysis); CRC cis rs2735413 0.914 rs11150035 chr16:78066449 G/C cg04733911 chr16:78082701 NA -0.37 -6.03 -0.32 4.33e-9 Systolic blood pressure (alcohol consumption interaction); CRC trans rs916888 0.773 rs199447 chr17:44812188 C/T cg10053473 chr17:62856997 LRRC37A3 -0.81 -9.06 -0.45 1.22e-17 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs875971 0.545 rs316316 chr7:65614257 C/T cg11764359 chr7:65958608 NA -0.45 -5.76 -0.3 1.89e-8 Aortic root size; CRC cis rs9303401 0.659 rs12600349 chr17:57054245 A/G cg10487724 chr17:56770010 TEX14;RAD51C -0.8 -10.1 -0.49 4.68e-21 Cognitive test performance; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg22753376 chr8:117768031 EIF3H 0.43 6.26 0.33 1.2e-9 Intelligence (multi-trait analysis); CRC cis rs1572438 0.899 rs9392198 chr6:860561 T/G cg21062780 chr6:887772 NA -0.38 -5.97 -0.31 6.21e-9 Aging; CRC cis rs9611565 0.659 rs56364401 chr22:41951243 T/G cg06481639 chr22:41940642 POLR3H -0.52 -6.09 -0.32 3.13e-9 Vitiligo; CRC cis rs875971 1.000 rs9986696 chr7:65704576 C/A cg00343986 chr7:65444356 GUSB -0.45 -6.69 -0.35 9.58e-11 Aortic root size; CRC cis rs896854 0.846 rs13254283 chr8:95914103 G/T cg09323728 chr8:95962352 TP53INP1 -0.4 -6.34 -0.33 7.7e-10 Type 2 diabetes; CRC cis rs3026101 0.671 rs3026125 chr17:5293627 T/G cg25236894 chr17:5323110 RPAIN;NUP88 0.42 6.84 0.35 3.98e-11 Body mass index; CRC cis rs3862030 0.720 rs2025713 chr10:104230156 A/G cg11453585 chr10:104263688 ACTR1A;SUFU -0.76 -13.31 -0.59 1.26e-32 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for body mass index; CRC cis rs17711722 1.000 rs17711722 chr7:65271197 C/T cg00343986 chr7:65444356 GUSB -0.57 -8.59 -0.43 3.53e-16 Calcium levels; CRC cis rs67311347 1.000 rs9882171 chr3:40518821 G/A cg24209194 chr3:40518798 ZNF619 0.43 6.42 0.33 4.74e-10 Renal cell carcinoma; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg20762182 chr15:69727293 KIF23 -0.39 -6.25 -0.33 1.25e-9 Liver disease severity in Alagille syndrome; CRC cis rs1552244 0.554 rs6800204 chr3:9995404 A/G cg08888203 chr3:10149979 C3orf24 0.47 7.23 0.37 3.47e-12 Alzheimer's disease; CRC cis rs9914988 0.943 rs9915673 chr17:27132893 G/C cg07195577 chr17:27052828 TLCD1 0.42 6.02 0.32 4.64e-9 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs1552244 1.000 rs4269070 chr3:10126083 C/G cg18598329 chr3:10140678 FANCD2;C3orf24 -0.9 -12.83 -0.58 7.64e-31 Alzheimer's disease; CRC cis rs57221529 0.766 rs4957053 chr5:575927 T/C cg16447950 chr5:562315 NA -0.83 -10.81 -0.51 1.71e-23 Lung disease severity in cystic fibrosis; CRC cis rs4474465 0.688 rs10501429 chr11:78279790 T/G cg27205649 chr11:78285834 NARS2 0.48 6.03 0.32 4.43e-9 Alzheimer's disease (survival time); CRC cis rs6815814 0.861 rs6531663 chr4:38792340 T/C cg06935464 chr4:38784597 TLR10 0.61 7.9 0.4 4.31e-14 Breast cancer; CRC cis rs7552404 1.000 rs4559448 chr1:76203456 A/G cg22875332 chr1:76189707 ACADM 0.69 9.24 0.45 3.13e-18 Blood metabolite levels;Acylcarnitine levels; CRC cis rs3820928 1.000 rs10167422 chr2:227777554 G/A cg11843606 chr2:227700838 RHBDD1 -0.41 -5.98 -0.31 5.91e-9 Pulmonary function; CRC cis rs9300255 0.722 rs10846515 chr12:123801672 T/G cg00376283 chr12:123451042 ABCB9 0.54 7.19 0.37 4.4e-12 Neutrophil percentage of white cells; CRC cis rs11077998 0.967 rs4789786 chr17:80504352 A/G cg10255544 chr17:80519551 FOXK2 -0.38 -5.92 -0.31 7.99e-9 Reticulocyte fraction of red cells; CRC cis rs2658782 0.789 rs3020073 chr11:93103830 T/C cg15737290 chr11:93063684 CCDC67 0.48 7.0 0.36 1.44e-11 Pulmonary function decline; CRC trans rs2727020 1.000 rs2727020 chr11:49111407 C/G cg21153622 chr11:89784906 NA 0.42 6.14 0.32 2.37e-9 Coronary artery disease; CRC cis rs7618915 0.501 rs3733045 chr3:52643307 A/G cg18404041 chr3:52824283 ITIH1 -0.38 -7.84 -0.4 6.39e-14 Bipolar disorder; CRC cis rs2845885 0.793 rs57779243 chr11:63882363 G/T cg24431193 chr11:63883947 FLRT1;MACROD1 0.75 8.87 0.44 4.69e-17 Body mass index; CRC cis rs34172651 0.517 rs7204288 chr16:24784531 A/G cg06505273 chr16:24850292 NA 0.49 6.16 0.32 2.08e-9 Intelligence (multi-trait analysis); CRC cis rs921968 0.565 rs2272188 chr2:219612282 C/T cg02176678 chr2:219576539 TTLL4 0.39 6.27 0.33 1.12e-9 Mean corpuscular hemoglobin concentration; CRC cis rs4888262 0.545 rs36097721 chr16:74648267 C/G cg01733217 chr16:74700730 RFWD3 0.8 12.31 0.56 6.7200000000000006e-29 Testicular germ cell tumor; CRC cis rs55871839 0.708 rs13268621 chr8:59811724 T/G cg07426533 chr8:59803705 TOX -0.34 -5.94 -0.31 7.22e-9 Pneumonia; CRC cis rs1997103 1.000 rs6968966 chr7:55411356 A/G cg17469321 chr7:55412551 NA 0.72 11.28 0.53 3.48e-25 QRS interval (sulfonylurea treatment interaction); CRC cis rs72945132 0.678 rs7113595 chr11:70236819 T/C cg00319359 chr11:70116639 PPFIA1 0.56 5.68 0.3 2.97e-8 Coronary artery disease; CRC cis rs10779751 0.770 rs6701524 chr1:11198502 A/G cg08854313 chr1:11322531 MTOR -0.62 -8.13 -0.41 8.68e-15 Body mass index; CRC cis rs6951245 0.935 rs11766669 chr7:1063593 C/T cg04025307 chr7:1156635 C7orf50 0.64 6.87 0.35 3.26e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs3858526 0.959 rs11039723 chr11:5956002 G/C cg26762873 chr11:5879799 OR52E8 -0.43 -6.13 -0.32 2.54e-9 DNA methylation (variation); CRC cis rs11711311 1.000 rs2242108 chr3:113433903 T/G cg15478005 chr3:113465772 ATP6V1A;NAA50 0.45 6.13 0.32 2.49e-9 IgG glycosylation; CRC cis rs2836974 0.897 rs13339986 chr21:40605982 T/C cg11644478 chr21:40555479 PSMG1 0.71 10.14 0.49 3.35e-21 Cognitive function; CRC cis rs3218092 0.701 rs11970772 chr6:41925290 A/T cg17623882 chr6:41773611 USP49 0.43 5.7 0.3 2.73e-8 Red cell distribution width; CRC cis rs3087591 0.708 rs2285894 chr17:29654876 T/A cg24425628 chr17:29625626 OMG;NF1 0.71 12.7 0.57 2.34e-30 Hip circumference; CRC trans rs9858542 0.953 rs9858280 chr3:49597737 T/C cg21582582 chr3:182698605 DCUN1D1 -0.54 -6.8 -0.35 5.08e-11 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg22636278 chr5:167913346 RARS 0.38 6.05 0.32 4.04e-9 Liver disease severity in Alagille syndrome; CRC cis rs1799949 1.000 rs8176289 chr17:41206056 T/C cg25072359 chr17:41440525 NA 0.45 6.82 0.35 4.26e-11 Menopause (age at onset); CRC cis rs4631830 0.900 rs10763588 chr10:51539762 G/T cg20129853 chr10:51489980 NA -0.36 -5.89 -0.31 9.73e-9 Prostate-specific antigen levels; CRC cis rs17826219 0.568 rs2626985 chr17:29077437 A/G cg13385521 chr17:29058706 SUZ12P 0.72 8.21 0.41 5.15e-15 Body mass index; CRC cis rs7618915 0.547 rs34610142 chr3:52708429 G/A cg10802521 chr3:52805072 NEK4 -0.58 -8.85 -0.44 5.34e-17 Bipolar disorder; CRC cis rs2530545 0.512 rs17169877 chr7:34626472 T/C cg14401837 chr7:34697493 NPSR1 0.37 5.81 0.31 1.45e-8 IgG glycosylation; CRC cis rs6952808 1.000 rs6954521 chr7:1886865 C/A cg21782813 chr7:2030301 MAD1L1 0.45 7.44 0.38 9.07e-13 Bipolar disorder and schizophrenia; CRC trans rs4332037 0.802 rs12113633 chr7:1932936 G/A cg11693508 chr17:37793320 STARD3 0.7 8.5 0.42 6.75e-16 Bipolar disorder; CRC cis rs9911578 0.967 rs8082544 chr17:57185807 C/T cg05425664 chr17:57184151 TRIM37 0.54 8.49 0.42 7.11e-16 Intelligence (multi-trait analysis); CRC cis rs73200209 0.744 rs57085207 chr12:116579289 T/C cg01776926 chr12:116560359 MED13L -0.62 -7.12 -0.37 6.94e-12 Total body bone mineral density; CRC cis rs6762 0.748 rs5030780 chr11:838110 C/T cg07691484 chr11:842764 TSPAN4;POLR2L -0.58 -8.6 -0.43 3.27e-16 Mean platelet volume; CRC cis rs514406 0.861 rs2448792 chr1:53268313 T/C cg24675658 chr1:53192096 ZYG11B 0.56 8.11 0.41 1.04e-14 Monocyte count; CRC cis rs9837602 1.000 rs793499 chr3:99565576 T/C cg07805332 chr3:99536008 MIR548G;C3orf26 0.48 6.44 0.33 4.13e-10 Breast cancer; CRC cis rs2404618 0.534 rs2214861 chr8:1490604 A/G cg13402656 chr8:1511478 DLGAP2 -0.72 -13.03 -0.58 1.42e-31 Lung cancer; CRC cis rs9926296 0.605 rs886952 chr16:89836781 G/A cg27121462 chr16:89883253 FANCA 0.57 9.1 0.45 8.71e-18 Vitiligo; CRC cis rs2072499 1.000 rs2253809 chr1:156172125 T/C cg06970220 chr1:156163860 SLC25A44 0.5 7.2 0.37 4.15e-12 Testicular germ cell tumor; CRC cis rs514406 0.722 rs7552139 chr1:53387379 G/C cg27535305 chr1:53392650 SCP2 -0.36 -6.47 -0.34 3.63e-10 Monocyte count; CRC cis rs637571 0.584 rs659824 chr11:65636509 A/G cg26695010 chr11:65641043 EFEMP2 0.57 9.02 0.45 1.59e-17 Eosinophil percentage of white cells; CRC cis rs1670533 1.000 rs11247972 chr4:1060550 A/G cg27284194 chr4:1044797 NA 0.5 6.22 0.32 1.51e-9 Recombination rate (females); CRC cis rs6860806 0.661 rs3763112 chr5:131586480 A/G cg18301423 chr5:131593218 PDLIM4 0.37 6.81 0.35 4.75e-11 Breast cancer; CRC cis rs12900413 0.687 rs12903462 chr15:90304075 C/T cg24249390 chr15:90295951 MESP1 -0.56 -8.69 -0.43 1.71e-16 Coronary artery aneurysm in Kawasaki disease; CRC cis rs2658782 0.724 rs1869914 chr11:93112492 C/G cg15737290 chr11:93063684 CCDC67 0.46 6.54 0.34 2.39e-10 Pulmonary function decline; CRC cis rs7769051 0.803 rs34334052 chr6:133231829 C/T cg07930552 chr6:133119739 C6orf192 0.58 6.61 0.34 1.52e-10 Type 2 diabetes nephropathy; CRC cis rs3733585 0.638 rs6414766 chr4:9956474 G/A cg11266682 chr4:10021025 SLC2A9 -0.48 -9.84 -0.48 3.47e-20 Cleft plate (environmental tobacco smoke interaction); CRC trans rs2303319 0.504 rs62189042 chr2:162602320 G/T cg13490827 chr1:46269305 MAST2 -0.69 -6.0 -0.31 5.24e-9 Cognitive function; CRC cis rs853679 0.517 rs4711164 chr6:28115156 C/T cg06470822 chr6:28175283 NA 1.03 13.59 0.6 1.04e-33 Depression; CRC cis rs2075671 0.857 rs11772849 chr7:100308412 G/A cg16850897 chr7:100343110 ZAN -0.6 -8.96 -0.44 2.45e-17 Other erythrocyte phenotypes; CRC cis rs6724607 0.905 rs10173771 chr2:191439248 T/C cg21644426 chr2:191273491 MFSD6 0.49 6.67 0.35 1.08e-10 Pulse pressure; CRC cis rs3849570 0.925 rs1464791 chr3:81893929 A/C cg07356753 chr3:81810745 GBE1 0.64 9.35 0.46 1.39e-18 Waist circumference;Body mass index; CRC cis rs738321 0.757 rs4820314 chr22:38518538 G/A cg25457927 chr22:38595422 NA -0.33 -6.36 -0.33 6.64e-10 Breast cancer; CRC trans rs4785204 1.000 rs8056208 chr16:50097104 A/G cg07960154 chr17:37760198 NEUROD2 -0.64 -6.03 -0.32 4.47e-9 Esophageal cancer (squamous cell); CRC cis rs79349575 0.783 rs12601858 chr17:47017477 T/C cg22482690 chr17:47019901 SNF8 0.48 8.01 0.4 2.01e-14 Type 2 diabetes; CRC cis rs4844614 0.904 rs4844388 chr1:207842900 G/A cg17822947 chr1:207842917 CR1L -0.38 -6.3 -0.33 9.45e-10 LDL cholesterol; CRC cis rs1862618 0.756 rs832548 chr5:56183637 G/C cg22800045 chr5:56110881 MAP3K1 0.62 6.64 0.34 1.29e-10 Initial pursuit acceleration; CRC cis rs6502050 0.835 rs4789737 chr17:80123269 G/A cg02741985 chr17:80059408 CCDC57 0.43 7.15 0.37 5.59e-12 Life satisfaction; CRC cis rs4975616 0.843 rs4975615 chr5:1315343 C/T cg26373071 chr5:1325741 CLPTM1L -0.4 -7.0 -0.36 1.46e-11 Lung cancer; CRC cis rs4474465 1.000 rs10899509 chr11:78170811 C/T cg27205649 chr11:78285834 NARS2 -0.45 -5.62 -0.3 3.99e-8 Alzheimer's disease (survival time); CRC trans rs13046373 0.905 rs4816372 chr21:32077414 A/T cg12488586 chr5:178220967 NA -0.39 -6.01 -0.31 4.83e-9 HDL cholesterol; CRC cis rs17345786 1.000 rs73863360 chr3:101316837 G/A cg12386194 chr3:101231763 SENP7 0.52 6.8 0.35 5.08e-11 Colonoscopy-negative controls vs population controls; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg25338623 chr11:67250427 AIP 0.4 5.96 0.31 6.35e-9 Intelligence (multi-trait analysis); CRC cis rs11628318 0.853 rs8003309 chr14:103050143 C/G cg02094049 chr14:103021097 NA -0.55 -7.05 -0.36 1.08e-11 Platelet count; CRC cis rs4731207 0.596 rs13224820 chr7:124655399 G/T cg23710748 chr7:124431027 NA -0.39 -6.25 -0.33 1.24e-9 Cutaneous malignant melanoma; CRC cis rs1434579 0.865 rs1434573 chr19:44923277 A/G cg15540054 chr19:45004280 ZNF180 0.5 6.32 0.33 8.64e-10 Tuberculosis; CRC cis rs4604732 0.527 rs79329288 chr1:247626513 T/C cg12758973 chr1:247694275 LOC148824;OR2C3 0.42 6.14 0.32 2.32e-9 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CRC cis rs10256972 0.521 rs7811577 chr7:1102829 C/G cg18765753 chr7:1198926 ZFAND2A -0.34 -6.04 -0.32 4.23e-9 Longevity;Endometriosis; CRC trans rs57221529 0.766 rs72703064 chr5:587825 T/C cg11887960 chr12:57824829 NA 0.63 6.89 0.36 2.93e-11 Lung disease severity in cystic fibrosis; CRC trans rs2055729 0.645 rs12543685 chr8:9747056 T/C cg06636001 chr8:8085503 FLJ10661 0.53 6.57 0.34 1.95e-10 Multiple myeloma (hyperdiploidy); CRC cis rs853679 0.517 rs9380057 chr6:28104634 G/T cg23161317 chr6:28129485 ZNF389 0.53 6.54 0.34 2.37e-10 Depression; CRC cis rs1564271 0.528 rs2209350 chr10:26987779 A/G cg13837822 chr10:26931731 LOC731789 0.56 8.75 0.43 1.11e-16 Overall survival in serous epithelial ovarian cancer treated with paclitaxel and cisplatin; CRC cis rs6952808 0.723 rs4721282 chr7:2025040 A/G cg00106254 chr7:1943704 MAD1L1 -0.47 -6.96 -0.36 1.8e-11 Bipolar disorder and schizophrenia; CRC cis rs10504229 0.554 rs17802082 chr8:58095867 C/T cg08219700 chr8:58056026 NA 0.52 6.75 0.35 6.78e-11 Developmental language disorder (linguistic errors); CRC cis rs10504229 0.769 rs17804383 chr8:58151830 A/G cg08219700 chr8:58056026 NA 0.45 5.74 0.3 2.11e-8 Developmental language disorder (linguistic errors); CRC cis rs4664293 0.605 rs12474082 chr2:160513914 A/G cg08347373 chr2:160653686 CD302 0.39 6.57 0.34 1.95e-10 Monocyte percentage of white cells; CRC cis rs7618501 0.633 rs2353579 chr3:50027774 C/T cg24110177 chr3:50126178 RBM5 -0.51 -7.95 -0.4 2.97e-14 Intelligence (multi-trait analysis); CRC cis rs71403859 0.502 rs12919417 chr16:71579711 A/G cg08717414 chr16:71523259 ZNF19 0.88 8.98 0.44 2.2e-17 Post bronchodilator FEV1; CRC cis rs45509595 0.841 rs200501 chr6:27788942 C/T cg03623178 chr6:28175578 NA 0.78 6.64 0.34 1.27e-10 Breast cancer; CRC cis rs7666738 1.000 rs2865983 chr4:99033352 C/T cg17366294 chr4:99064904 C4orf37 0.45 7.32 0.37 1.91e-12 Colonoscopy-negative controls vs population controls; CRC cis rs2073300 0.609 rs79250740 chr20:23417165 G/A cg12062639 chr20:23401060 NAPB 0.84 7.67 0.39 2.03e-13 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs9311676 0.656 rs11918201 chr3:58387777 C/T cg06643156 chr3:58380774 PXK 0.41 6.33 0.33 7.82e-10 Systemic lupus erythematosus; CRC cis rs478304 0.651 rs4930312 chr11:65499719 G/A cg27068330 chr11:65405492 SIPA1 -0.63 -9.75 -0.47 6.92e-20 Acne (severe); CRC cis rs79349575 0.745 rs170319 chr17:46991531 T/C cg00947319 chr17:47005597 UBE2Z -0.34 -5.87 -0.31 1.07e-8 Type 2 diabetes; CRC cis rs12580194 0.593 rs66902680 chr12:55724080 A/C cg23425280 chr12:56401806 NA 0.48 5.82 0.31 1.39e-8 Cancer; CRC cis rs2251381 0.741 rs2735966 chr21:30538174 G/A cg24692254 chr21:30365293 RNF160 0.74 12.05 0.55 6.24e-28 Selective IgA deficiency; CRC cis rs67311347 1.000 rs73076046 chr3:40447724 C/T cg09455208 chr3:40491958 NA 0.49 9.23 0.45 3.4e-18 Renal cell carcinoma; CRC cis rs1401999 0.898 rs9876143 chr3:183731362 C/G cg20387954 chr3:183756860 HTR3D 0.46 7.82 0.4 7.01e-14 Anterior chamber depth; CRC cis rs11098499 0.754 rs10518300 chr4:120249499 G/T cg09307838 chr4:120376055 NA -0.6 -9.39 -0.46 1.07e-18 Corneal astigmatism; CRC cis rs9916302 0.861 rs8079590 chr17:37426201 T/C cg15445000 chr17:37608096 MED1 0.42 9.24 0.45 3.08e-18 Glomerular filtration rate (creatinine); CRC trans rs2303319 0.504 rs35304298 chr2:162617185 G/T cg22922770 chr7:98923339 ARPC1A -0.67 -5.99 -0.31 5.55e-9 Cognitive function; CRC cis rs947211 1.000 rs947211 chr1:205752665 A/G cg07157834 chr1:205819609 PM20D1 0.42 5.88 0.31 1.01e-8 Parkinson's disease; CRC cis rs4713118 0.869 rs9283881 chr6:27715255 A/T cg06470822 chr6:28175283 NA 0.72 10.34 0.5 6.75e-22 Parkinson's disease; CRC cis rs1008375 0.966 rs4698621 chr4:17587565 C/T cg16339924 chr4:17578868 LAP3 0.6 7.91 0.4 3.93e-14 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs798554 0.797 rs35957220 chr7:2812632 C/G cg19346786 chr7:2764209 NA -0.43 -7.14 -0.37 5.85e-12 Height; CRC cis rs13191362 1.000 rs34398656 chr6:162999612 G/T cg21926612 chr6:163149169 PACRG;PARK2 0.77 11.26 0.53 4.18e-25 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs10046574 0.831 rs56285116 chr7:135164950 C/T cg27474649 chr7:135195673 CNOT4 0.69 5.7 0.3 2.61e-8 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs4713118 0.628 rs9295740 chr6:27689502 G/A cg26587870 chr6:27730563 NA -0.43 -6.01 -0.31 4.93e-9 Parkinson's disease; CRC cis rs514406 0.698 rs522259 chr1:53365481 A/G cg27535305 chr1:53392650 SCP2 -0.44 -7.72 -0.39 1.44e-13 Monocyte count; CRC cis rs7508679 0.692 rs10413734 chr19:7227871 T/G cg00428638 chr19:7224713 INSR -0.89 -14.31 -0.62 1.84e-36 Hypothyroidism; CRC cis rs875971 0.545 rs75577046 chr7:65958716 A/G cg03233332 chr7:66118400 NA -0.43 -5.9 -0.31 9.26e-9 Aortic root size; CRC cis rs8044995 0.563 rs3785116 chr16:68372730 G/A cg09835421 chr16:68378352 PRMT7 -0.85 -8.42 -0.42 1.16e-15 Schizophrenia; CRC trans rs12432203 1.000 rs72622431 chr14:51732854 G/T cg14592830 chr9:122318704 NA 0.57 6.01 0.31 4.88e-9 Cancer; CRC cis rs9768139 0.733 rs56205111 chr7:158121055 T/C cg25566285 chr7:158114605 PTPRN2 0.47 7.46 0.38 8.02e-13 Calcium levels; CRC cis rs394563 0.775 rs420430 chr6:149785539 T/G cg03678062 chr6:149772716 ZC3H12D -0.37 -6.42 -0.33 4.69e-10 Dupuytren's disease; CRC trans rs9467711 0.606 rs13203358 chr6:26590578 A/T cg06606381 chr12:133084897 FBRSL1 -0.85 -6.44 -0.33 4.18e-10 Autism spectrum disorder or schizophrenia; CRC cis rs875971 0.862 rs10261398 chr7:65750164 A/G cg18252515 chr7:66147081 NA 0.39 5.72 0.3 2.45e-8 Aortic root size; CRC cis rs6502050 0.805 rs56020943 chr17:80105248 C/A cg02741985 chr17:80059408 CCDC57 0.43 7.15 0.37 5.66e-12 Life satisfaction; CRC cis rs12594515 0.967 rs11856523 chr15:45989495 C/T cg01629716 chr15:45996671 NA 0.41 8.46 0.42 9.03e-16 Waist circumference;Weight; CRC cis rs2880765 0.835 rs11856869 chr15:86029097 C/G cg17133734 chr15:86042851 AKAP13 0.43 6.89 0.35 2.92e-11 Coronary artery disease; CRC trans rs61931739 0.500 rs7310237 chr12:34483435 G/A cg26384229 chr12:38710491 ALG10B 0.61 8.95 0.44 2.61e-17 Morning vs. evening chronotype; CRC cis rs10979 1.000 rs3748072 chr6:143889757 C/T cg25407410 chr6:143891975 LOC285740 -0.82 -13.4 -0.59 5.5e-33 Hypospadias; CRC cis rs12142240 0.692 rs7532149 chr1:46824932 A/C cg14993813 chr1:46806288 NSUN4 -0.49 -6.22 -0.32 1.55e-9 Menopause (age at onset); CRC cis rs7914558 0.901 rs1926034 chr10:104829102 G/A cg15744005 chr10:104629667 AS3MT -0.34 -7.13 -0.37 6.38e-12 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs7107174 0.786 rs4945266 chr11:78027488 A/G cg02023728 chr11:77925099 USP35 0.52 7.37 0.38 1.4e-12 Testicular germ cell tumor; CRC cis rs9796 0.621 rs58109657 chr15:41471750 A/G cg18705301 chr15:41695430 NDUFAF1 0.43 7.08 0.36 8.69e-12 Menopause (age at onset); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg01168649 chr22:31892074 SFI1 0.45 6.36 0.33 6.58e-10 Intelligence (multi-trait analysis); CRC cis rs870825 0.616 rs28636679 chr4:185627481 C/T cg04058563 chr4:185651563 MLF1IP 0.72 9.36 0.46 1.32e-18 Blood protein levels; CRC cis rs7777484 0.534 rs2533888 chr7:2831083 T/C cg09658497 chr7:2847517 GNA12 -0.41 -6.82 -0.35 4.38e-11 Height; CRC cis rs853679 0.517 rs868987 chr6:28110148 A/G cg12172441 chr6:28176163 NA -0.63 -7.57 -0.39 3.83e-13 Depression; CRC cis rs12477438 0.765 rs7340412 chr2:99661148 G/A cg26064155 chr2:99771622 LIPT1;TSGA10 -0.63 -8.55 -0.43 4.61e-16 Chronic sinus infection; CRC cis rs4713118 0.587 rs9393899 chr6:28133528 G/C cg15786705 chr6:28176104 NA 0.78 9.83 0.48 3.57e-20 Parkinson's disease; CRC cis rs875971 0.755 rs76288834 chr7:66069802 G/A cg00343986 chr7:65444356 GUSB -0.44 -5.98 -0.31 5.72e-9 Aortic root size; CRC cis rs12580194 0.593 rs67015069 chr12:55759968 T/A cg23425280 chr12:56401806 NA 0.48 5.8 0.3 1.55e-8 Cancer; CRC cis rs736408 0.609 rs13061423 chr3:52790213 T/C cg18404041 chr3:52824283 ITIH1 -0.42 -8.67 -0.43 2.06e-16 Bipolar disorder; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg22437020 chr17:41623744 ETV4 0.45 6.3 0.33 9.36e-10 Response to antipsychotic treatment; CRC cis rs9534288 0.797 rs6561280 chr13:46583691 T/C cg15192986 chr13:46630673 CPB2 -0.68 -9.9 -0.48 2.1e-20 Blood protein levels; CRC cis rs853679 0.517 rs67878650 chr6:28142587 G/C cg12963246 chr6:28129442 ZNF389 0.5 5.75 0.3 2e-8 Depression; CRC cis rs12681288 0.823 rs12681230 chr8:994422 G/A cg04851639 chr8:1020857 NA -0.37 -7.99 -0.4 2.24e-14 Schizophrenia; CRC cis rs4664293 0.669 rs10174515 chr2:160462035 A/G cg08347373 chr2:160653686 CD302 -0.39 -6.49 -0.34 3.11e-10 Monocyte percentage of white cells; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg07292445 chr17:27055725 NEK8 0.49 6.59 0.34 1.71e-10 Anxiety disorder; CRC cis rs2120019 1.000 rs12901243 chr15:75374233 C/T cg11632617 chr15:75315747 PPCDC -0.56 -7.96 -0.4 2.86e-14 Blood trace element (Zn levels); CRC cis rs10752881 1.000 rs4304541 chr1:182970238 G/T ch.1.3577855R chr1:183094577 LAMC1 0.86 15.01 0.64 3.66e-39 Colorectal cancer; CRC trans rs3960554 0.808 rs59882870 chr7:75638421 G/A cg19862616 chr7:65841803 NCRNA00174 0.66 7.41 0.38 1.07e-12 Eotaxin levels; CRC cis rs4731207 0.596 rs1904973 chr7:124669547 G/A cg23710748 chr7:124431027 NA -0.39 -6.14 -0.32 2.44e-9 Cutaneous malignant melanoma; CRC cis rs747650 0.961 rs7945315 chr11:47110652 A/C cg19486271 chr11:47235900 DDB2 -0.45 -6.73 -0.35 7.77e-11 Acne (severe); CRC cis rs2530545 0.762 rs28605015 chr7:34666834 C/A cg14401837 chr7:34697493 NPSR1 0.43 6.34 0.33 7.68e-10 IgG glycosylation; CRC cis rs9611565 0.559 rs5758428 chr22:42106216 G/A cg03806693 chr22:41940476 POLR3H 1.07 13.47 0.6 3.02e-33 Vitiligo; CRC cis rs2243480 1.000 rs160646 chr7:65556280 C/T cg12463550 chr7:65579703 CRCP 0.68 6.61 0.34 1.54e-10 Diabetic kidney disease; CRC cis rs2032447 0.714 rs175319 chr6:25956172 A/G cg26028573 chr6:26043587 HIST1H2BB 0.46 6.62 0.34 1.43e-10 Intelligence (multi-trait analysis); CRC cis rs10484885 0.824 rs112817281 chr6:90555658 G/A cg13799429 chr6:90582589 CASP8AP2 -0.73 -7.76 -0.39 1.08e-13 QRS interval (sulfonylurea treatment interaction); CRC cis rs4253772 0.637 rs8139035 chr22:46651367 A/G cg09491104 chr22:46646882 C22orf40 -0.47 -7.29 -0.37 2.36e-12 LDL cholesterol;Cholesterol, total; CRC trans rs7824557 0.527 rs10109537 chr8:11239640 C/T cg06636001 chr8:8085503 FLJ10661 -0.44 -6.47 -0.34 3.6e-10 Retinal vascular caliber; CRC trans rs10838798 0.523 rs11039543 chr11:48168103 G/A cg03929089 chr4:120376271 NA -0.48 -6.68 -0.35 1.02e-10 Height; CRC cis rs4713118 0.955 rs9468201 chr6:27687035 C/T cg02683197 chr6:28174875 NA 0.57 7.52 0.38 5.18e-13 Parkinson's disease; CRC cis rs56104184 0.775 rs117744769 chr19:49402686 G/T cg21252483 chr19:49399788 TULP2 -0.43 -6.53 -0.34 2.55e-10 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; CRC cis rs2180341 0.960 rs9401952 chr6:127677027 A/C cg27446573 chr6:127587934 RNF146 0.93 13.48 0.6 2.71e-33 Breast cancer; CRC cis rs274567 0.501 rs272856 chr5:131687081 G/C cg12564285 chr5:131593104 PDLIM4 0.45 7.32 0.37 1.9e-12 Blood metabolite levels; CRC cis rs7258465 1.000 rs271621 chr19:18631332 C/A cg10790698 chr19:18539756 SSBP4 -0.46 -8.79 -0.44 8.55e-17 Breast cancer; CRC cis rs1656402 1.000 rs2950878 chr2:233424954 C/T cg03852847 chr2:233439513 NA 0.45 7.71 0.39 1.54e-13 Non-small cell lung cancer (survival); CRC cis rs11719291 0.915 rs1048940 chr3:48725707 C/T cg00383909 chr3:49044727 WDR6 1.27 10.45 0.5 2.98e-22 Cognitive function; CRC cis rs17767392 0.846 rs61991213 chr14:71796441 C/T cg13720639 chr14:72061746 SIPA1L1 -0.44 -5.88 -0.31 1.02e-8 Mitral valve prolapse; CRC cis rs4665809 1.000 rs6546726 chr2:26275116 A/G cg26119090 chr2:26468346 HADHA;HADHB -0.61 -7.92 -0.4 3.72e-14 Gut microbiome composition (summer); CRC cis rs875971 1.000 rs7792762 chr7:66004138 T/C cg00343986 chr7:65444356 GUSB 0.45 6.41 0.33 5.12e-10 Aortic root size; CRC cis rs3741151 0.773 rs58334887 chr11:73171510 A/C cg17517138 chr11:73019481 ARHGEF17 1.04 8.44 0.42 1.01e-15 GIP levels in response to oral glucose tolerance test (120 minutes); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg00638210 chr3:126732518 PLXNA1 0.29 6.01 0.31 4.97e-9 Liver disease severity in Alagille syndrome; CRC cis rs7589728 1.000 rs12473740 chr2:88527647 A/G cg24977027 chr2:88469347 THNSL2 0.56 6.66 0.34 1.15e-10 Plasma clusterin levels; CRC cis rs13191362 1.000 rs1333963 chr6:163192571 A/G cg23758597 chr6:163146217 PARK2 -0.7 -7.12 -0.37 6.76e-12 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs2857891 1.000 rs1388527 chr11:6948441 C/T cg22096450 chr11:6947773 ZNF215 0.61 6.38 0.33 6.15e-10 Response to cytadine analogues (cytosine arabinoside); CRC trans rs16846053 0.786 rs116099394 chr2:162600082 G/T cg06075789 chr19:39894767 NA -0.67 -5.97 -0.31 6.06e-9 Blood osmolality (transformed sodium); CRC cis rs9399135 0.967 rs6925424 chr6:135313948 T/A cg24558204 chr6:135376177 HBS1L 0.51 8.13 0.41 9e-15 Red blood cell count; CRC cis rs1799949 1.000 rs34942571 chr17:41273379 G/C cg01879757 chr17:41196368 BRCA1 -0.41 -6.14 -0.32 2.41e-9 Menopause (age at onset); CRC cis rs3617 0.573 rs13072537 chr3:52896032 C/A cg07507251 chr3:52567010 NT5DC2 0.4 6.01 0.31 4.92e-9 Red blood cell count;Autism spectrum disorder or schizophrenia; CRC trans rs1814175 0.645 rs28436748 chr11:50046422 G/A cg03929089 chr4:120376271 NA -0.89 -16.04 -0.66 3.41e-43 Height; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg25327839 chr11:73308997 FAM168A 0.39 7.06 0.36 1.01e-11 Liver disease severity in Alagille syndrome; CRC cis rs57221529 0.766 rs4081846 chr5:574019 G/A cg09021430 chr5:549028 NA -0.71 -7.95 -0.4 2.98e-14 Lung disease severity in cystic fibrosis; CRC cis rs236352 0.521 rs58214515 chr6:36827416 T/C cg10099585 chr6:36853529 C6orf89 -0.42 -5.79 -0.3 1.66e-8 Heart rate; CRC cis rs7705042 0.828 rs181826 chr5:141526057 C/A cg07392085 chr5:141489673 NDFIP1 0.45 7.25 0.37 2.94e-12 Asthma; CRC cis rs11098499 0.697 rs4373140 chr4:120307698 A/G cg24375607 chr4:120327624 NA 0.51 7.86 0.4 5.5e-14 Corneal astigmatism; CRC cis rs9916302 0.653 rs11657058 chr17:37699378 T/G cg07936489 chr17:37558343 FBXL20 -0.92 -11.89 -0.55 2.39e-27 Glomerular filtration rate (creatinine); CRC cis rs1267303 0.562 rs2476162 chr1:47007324 G/A cg08533674 chr1:46993347 NA -0.59 -7.77 -0.39 1.03e-13 Monobrow; CRC cis rs2688608 0.592 rs11000757 chr10:75486815 T/C cg23231163 chr10:75533350 FUT11 -0.37 -5.9 -0.31 9.05e-9 Inflammatory bowel disease; CRC cis rs9467711 0.606 rs9379875 chr6:26444732 C/T cg12315302 chr6:26189340 HIST1H4D 0.82 6.33 0.33 8.12e-10 Autism spectrum disorder or schizophrenia; CRC cis rs3757247 0.729 rs4707605 chr6:90915601 C/T cg06866423 chr6:90926672 BACH2 0.4 7.01 0.36 1.33e-11 Vitiligo;Type 1 diabetes; CRC trans rs7395662 0.963 rs4882109 chr11:48557685 C/T cg21153622 chr11:89784906 NA -0.45 -7.24 -0.37 3.25e-12 HDL cholesterol; CRC cis rs1395 0.710 rs11682913 chr2:27473649 G/A cg23587288 chr2:27483067 SLC30A3 -0.37 -5.65 -0.3 3.52e-8 Blood metabolite levels; CRC cis rs4604732 0.631 rs12036460 chr1:247626928 A/G cg12754571 chr1:247694271 LOC148824;OR2C3 0.41 5.78 0.3 1.74e-8 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CRC cis rs929354 1.000 rs1182414 chr7:157058363 G/A cg05182265 chr7:156933206 UBE3C 0.67 12.26 0.56 1.01e-28 Body mass index; CRC cis rs10540 0.915 rs35389167 chr11:460765 A/G cg03934478 chr11:495069 RNH1 0.66 7.41 0.38 1.1e-12 Body mass index; CRC cis rs4332037 0.539 rs56016347 chr7:2060126 C/T cg23378565 chr7:2036160 MAD1L1 -0.43 -6.09 -0.32 3.16e-9 Bipolar disorder; CRC cis rs7959452 0.557 rs899224 chr12:69784774 A/G cg22834771 chr12:69754056 YEATS4 -0.54 -8.1 -0.41 1.07e-14 Blood protein levels; CRC cis rs7208859 0.673 rs73277967 chr17:29184166 T/A cg13385521 chr17:29058706 SUZ12P 0.69 8.02 0.4 1.81e-14 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs9926296 0.744 rs164749 chr16:89708224 A/C cg03605463 chr16:89740564 NA 0.47 7.65 0.39 2.27e-13 Vitiligo; CRC cis rs875971 1.000 rs35149210 chr7:65929925 T/C cg12463550 chr7:65579703 CRCP 0.48 6.78 0.35 5.54e-11 Aortic root size; CRC cis rs2115630 1.000 rs55646601 chr15:85323568 G/T cg11189052 chr15:85197271 WDR73 -0.61 -10.06 -0.49 6.07e-21 P wave terminal force; CRC cis rs10540 1.000 rs10540 chr11:494662 G/A cg03352830 chr11:487213 PTDSS2 0.67 7.7 0.39 1.63e-13 Body mass index; CRC cis rs12497850 0.931 rs7626445 chr3:49114544 C/T cg07636037 chr3:49044803 WDR6 1.07 18.9 0.72 1.84e-54 Parkinson's disease; CRC cis rs798554 0.796 rs2533884 chr7:2836848 T/G cg19346786 chr7:2764209 NA -0.43 -7.32 -0.37 1.89e-12 Height; CRC cis rs7927771 0.524 rs10838782 chr11:47877800 A/G cg20307385 chr11:47447363 PSMC3 0.45 6.61 0.34 1.53e-10 Subjective well-being; CRC cis rs16975963 0.594 rs73039018 chr19:38217894 C/A cg15135657 chr19:38346511 NA -0.47 -6.39 -0.33 5.69e-10 Longevity; CRC cis rs4862750 0.872 rs13101408 chr4:187894777 G/A cg10295955 chr4:187884368 NA -1.05 -26.61 -0.83 5.09e-84 Lobe attachment (rater-scored or self-reported); CRC cis rs9928842 0.664 rs8053265 chr16:75221851 C/T cg03088958 chr16:75232330 NA -0.32 -5.72 -0.3 2.34e-8 Alcoholic chronic pancreatitis; CRC cis rs9916302 0.653 rs4239223 chr17:37717004 T/C cg15445000 chr17:37608096 MED1 0.35 6.21 0.32 1.63e-9 Glomerular filtration rate (creatinine); CRC cis rs1552244 0.882 rs17050699 chr3:10037167 G/A cg02579736 chr3:10068473 FANCD2;CIDECP 0.93 12.04 0.55 6.69e-28 Alzheimer's disease; CRC cis rs1552244 0.808 rs7615088 chr3:10035896 A/T cg18598329 chr3:10140678 FANCD2;C3orf24 -0.81 -10.69 -0.51 4.35e-23 Alzheimer's disease; CRC cis rs6676180 0.555 rs947430 chr1:119778734 G/A cg05756136 chr1:119680316 WARS2 -0.44 -6.54 -0.34 2.41e-10 Monobrow; CRC cis rs117623576 0.941 rs67225815 chr10:32408946 C/T cg03047570 chr10:32398778 NA -0.81 -9.08 -0.45 1.05e-17 Anti-saccade response; CRC cis rs1865760 1.000 rs9358895 chr6:25924655 C/T cg17691542 chr6:26056736 HIST1H1C 0.56 8.47 0.42 8.18e-16 Height; CRC cis rs2457480 0.516 rs7901877 chr10:44633766 G/C cg09554077 chr10:44749378 NA 0.47 6.01 0.31 5.01e-9 Coronary artery disease; CRC cis rs28386778 0.830 rs2665798 chr17:61921397 C/T cg11494091 chr17:61959527 GH2 0.6 10.2 0.49 2.03e-21 Prudent dietary pattern; CRC cis rs11969893 0.737 rs9498439 chr6:101404768 A/T cg12253828 chr6:101329408 ASCC3 0.8 6.53 0.34 2.47e-10 Economic and political preferences (immigration/crime); CRC cis rs3008870 0.920 rs2755253 chr1:67470843 C/T cg08660285 chr1:67390436 MIER1;WDR78 0.68 9.55 0.47 3e-19 Lymphocyte percentage of white cells; CRC cis rs2625529 0.652 rs1481862 chr15:72245648 G/A cg16672083 chr15:72433130 SENP8 0.46 6.96 0.36 1.83e-11 Red blood cell count; CRC cis rs7703744 0.634 rs112352373 chr5:118687625 C/G cg02283238 chr5:118691126 TNFAIP8 0.47 6.27 0.33 1.14e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs13191362 0.872 rs73020362 chr6:163005737 A/C cg06582575 chr6:163149167 PACRG;PARK2 0.77 10.59 0.5 9.54e-23 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs2070488 0.804 rs35463537 chr3:38498248 T/C cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.75 13.13 0.59 5.98e-32 Electrocardiographic conduction measures; CRC cis rs2811415 0.531 rs13081382 chr3:127740304 C/G cg13719885 chr3:127795394 NA -0.37 -5.61 -0.3 4.19e-8 Lung function (FEV1/FVC); CRC cis rs10751667 0.666 rs11246358 chr11:967349 G/A ch.11.42038R chr11:967971 AP2A2 0.6 10.28 0.49 1.15e-21 Alzheimer's disease (late onset); CRC cis rs45509595 0.841 rs2747054 chr6:27783359 A/G cg23259851 chr6:27775964 HIST1H2AI;HIST1H2BL 0.71 5.93 0.31 7.74e-9 Breast cancer; CRC cis rs1218582 0.772 rs4845689 chr1:154885524 A/G cg16680214 chr1:154839983 KCNN3 -0.45 -8.95 -0.44 2.62e-17 Prostate cancer; CRC cis rs8031584 0.918 rs61997139 chr15:31273602 C/G cg08704250 chr15:31115839 NA -0.43 -8.33 -0.42 2.27e-15 Huntington's disease progression; CRC cis rs2439831 0.850 rs12442129 chr15:44055856 C/T cg02155558 chr15:43621948 ADAL;LCMT2 0.69 7.61 0.39 2.95e-13 Lung cancer in ever smokers; CRC cis rs7772486 0.727 rs10223508 chr6:146285205 C/T cg23711669 chr6:146136114 FBXO30 -0.65 -10.81 -0.51 1.71e-23 Lobe attachment (rater-scored or self-reported); CRC cis rs904251 0.523 rs10947675 chr6:37479972 G/A cg01843034 chr6:37503916 NA -0.4 -7.24 -0.37 3.1e-12 Cognitive performance; CRC cis rs3750082 0.889 rs13244998 chr7:32912910 T/C cg05721444 chr7:32995514 FKBP9 0.51 7.87 0.4 5.33e-14 Glomerular filtration rate (creatinine); CRC trans rs12432203 1.000 rs72622423 chr14:51726108 A/T cg14592830 chr9:122318704 NA 0.61 6.28 0.33 1.08e-9 Cancer; CRC cis rs7615952 0.641 rs60839048 chr3:125807938 G/A cg18479299 chr3:125709523 NA -0.56 -6.6 -0.34 1.6e-10 Blood pressure (smoking interaction); CRC cis rs11971779 0.680 rs7805767 chr7:139111415 A/G cg23387468 chr7:139079360 LUC7L2 0.41 7.05 0.36 1.04e-11 Diisocyanate-induced asthma; CRC cis rs9858542 0.953 rs10640 chr3:49454277 G/A cg03060546 chr3:49711283 APEH -0.47 -6.66 -0.34 1.16e-10 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs10256972 0.504 rs2949178 chr7:1209925 T/C cg03188948 chr7:1209495 NA 0.6 9.13 0.45 7.26e-18 Longevity;Endometriosis; CRC cis rs7107174 0.786 rs4945269 chr11:78047077 A/G cg02023728 chr11:77925099 USP35 0.47 8.15 0.41 7.75e-15 Testicular germ cell tumor; CRC cis rs2839186 0.771 rs2839155 chr21:47639992 A/G cg05896524 chr21:47604654 C21orf56 0.46 6.87 0.35 3.22e-11 Testicular germ cell tumor; CRC cis rs4927850 0.521 rs4927679 chr3:195658360 C/T cg01181863 chr3:195395398 SDHAP2 0.57 8.55 0.43 4.85e-16 Pancreatic cancer; CRC cis rs8072100 1.000 rs8072100 chr17:45674687 A/T cg08085267 chr17:45401833 C17orf57 0.67 10.85 0.51 1.24e-23 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs926938 0.563 rs360635 chr1:115420518 A/C cg12756093 chr1:115239321 AMPD1 0.56 8.21 0.41 5.11e-15 Autism; CRC cis rs6500602 0.727 rs6500607 chr16:4503631 C/T cg14951292 chr16:4525986 HMOX2;NMRAL1 0.59 9.13 0.45 7.28e-18 Schizophrenia; CRC cis rs7772486 0.727 rs12190966 chr6:146146820 T/G cg23711669 chr6:146136114 FBXO30 0.67 11.16 0.52 1e-24 Lobe attachment (rater-scored or self-reported); CRC cis rs7772486 0.701 rs697056 chr6:146003897 C/T cg13319975 chr6:146136371 FBXO30 0.44 6.41 0.33 4.91e-10 Lobe attachment (rater-scored or self-reported); CRC cis rs6860806 0.507 rs272882 chr5:131669161 G/T cg18758796 chr5:131593413 PDLIM4 0.39 6.35 0.33 7.24e-10 Breast cancer; CRC cis rs4654899 0.643 rs2053981 chr1:21227083 G/A cg02927042 chr1:21476669 EIF4G3 -0.41 -6.46 -0.34 3.84e-10 Superior frontal gyrus grey matter volume; CRC cis rs10504229 0.683 rs2101864 chr8:58113226 C/T cg22535103 chr8:58192502 C8orf71 -0.7 -9.2 -0.45 4.33e-18 Developmental language disorder (linguistic errors); CRC cis rs9467711 0.659 rs72844462 chr6:26563864 A/C cg12315302 chr6:26189340 HIST1H4D 0.99 6.93 0.36 2.22e-11 Autism spectrum disorder or schizophrenia; CRC cis rs2180341 0.960 rs7773484 chr6:127670779 T/C cg27446573 chr6:127587934 RNF146 0.97 13.77 0.6 2.17e-34 Breast cancer; CRC cis rs6499255 0.951 rs9921045 chr16:69708698 C/T cg15192750 chr16:69999425 NA 0.56 7.47 0.38 7.35e-13 IgE levels; CRC cis rs9292777 0.901 rs957100 chr5:40426420 G/T cg09067459 chr5:40385259 NA 0.53 9.32 0.46 1.7e-18 Crohn's disease;Multiple sclerosis; CRC cis rs9463078 0.774 rs7451423 chr6:45241343 C/T cg25276700 chr6:44698697 NA -0.27 -6.35 -0.33 7.14e-10 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; CRC cis rs12476592 0.543 rs262513 chr2:63890766 T/A cg10828910 chr2:63850056 LOC388955 0.5 6.26 0.33 1.23e-9 Childhood ear infection; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg14761318 chr5:68788469 OCLN 0.39 6.52 0.34 2.71e-10 Liver disease severity in Alagille syndrome; CRC cis rs59918340 0.764 rs9324542 chr8:142227854 A/T cg03316587 chr8:142245164 NA 0.37 5.63 0.3 3.81e-8 Immature fraction of reticulocytes; CRC cis rs7580658 0.963 rs10803585 chr2:128130108 G/A cg09760422 chr2:128146352 NA -0.36 -6.9 -0.36 2.6e-11 Protein C levels; CRC cis rs7615952 0.641 rs12491577 chr3:125731131 C/T cg05084668 chr3:125655381 ALG1L -0.47 -6.68 -0.35 1.02e-10 Blood pressure (smoking interaction); CRC cis rs4713118 0.539 rs200967 chr6:27862127 A/G cg15845792 chr6:28175446 NA 0.76 10.74 0.51 2.89e-23 Parkinson's disease; CRC cis rs11958404 0.932 rs72816592 chr5:157435246 A/G cg05962755 chr5:157440814 NA 1.01 12.88 0.58 5.12e-31 IgG glycosylation; CRC cis rs4246215 1 rs4246215 chr11:61564299 G/T cg06781209 chr11:61594997 FADS2 -0.4 -6.01 -0.31 4.91e-9 Plasma omega-3 polyunsaturated fatty acid levels (alphalinolenic acid);Platelet count;Inflammatory bowel disease;Trans fatty acid levels;Crohn's disease;Plasma omega-3 polyunsaturated fatty acid level (eicosapentaenoic acid);Red blood cell fatty acid levels;Plasma omega-3 polyunsaturated fatty acid levels (docosapentaenoic acid); CRC cis rs910316 1.000 rs8003506 chr14:75586288 A/C cg08847533 chr14:75593920 NEK9 -0.94 -16.83 -0.68 2.79e-46 Height; CRC trans rs1005277 0.579 rs2505194 chr10:38393881 C/T cg23533926 chr12:111358616 MYL2 -0.52 -7.67 -0.39 2.03e-13 Extrinsic epigenetic age acceleration; CRC cis rs9911578 0.900 rs7214335 chr17:57158840 G/A cg12560992 chr17:57184187 TRIM37 0.88 16.34 0.67 2.37e-44 Intelligence (multi-trait analysis); CRC cis rs1124376 1.000 rs9857135 chr3:20147790 G/A cg05072819 chr3:20081367 KAT2B 0.49 5.92 0.31 8.07e-9 Bipolar disorder and schizophrenia; CRC cis rs7726839 0.540 rs58599998 chr5:596087 A/G cg09021430 chr5:549028 NA -0.72 -8.29 -0.42 2.99e-15 Obesity-related traits; CRC cis rs600806 0.850 rs10858092 chr1:109943893 A/G cg23032129 chr1:109941072 SORT1 0.28 5.89 0.31 9.37e-9 Intelligence (multi-trait analysis); CRC cis rs6502050 0.835 rs67682841 chr17:80117745 T/C cg13198984 chr17:80129470 CCDC57 0.46 8.24 0.41 4.11e-15 Life satisfaction; CRC trans rs1814175 0.791 rs1722023 chr11:49908136 G/C cg03929089 chr4:120376271 NA -0.98 -19.27 -0.73 6.62e-56 Height; CRC cis rs4891159 0.790 rs56077581 chr18:74116865 T/G cg24786174 chr18:74118243 ZNF516 -0.92 -16.83 -0.68 2.69e-46 Longevity; CRC cis rs12291225 0.535 rs16930126 chr11:14404983 C/T cg05501817 chr11:14380813 RRAS2 0.41 5.67 0.3 3.19e-8 Sense of smell; CRC trans rs916888 0.821 rs70600 chr17:44860021 C/T cg10053473 chr17:62856997 LRRC37A3 -0.73 -8.31 -0.42 2.51e-15 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs12586317 0.547 rs28569331 chr14:35473584 T/C cg05294307 chr14:35346193 BAZ1A -0.72 -7.89 -0.4 4.61e-14 Psoriasis; CRC cis rs8060686 0.841 rs56374641 chr16:67908713 G/T cg19582491 chr16:67682965 RLTPR -0.58 -6.95 -0.36 1.99e-11 HDL cholesterol;Metabolic syndrome; CRC cis rs1799949 0.602 rs8176257 chr17:41216205 G/T cg19454999 chr17:41278357 BRCA1;NBR2 0.46 6.39 0.33 5.66e-10 Menopause (age at onset); CRC cis rs35146811 0.807 rs10228764 chr7:99608029 A/G cg03265037 chr7:99691720 MIR25;MCM7;MIR106B;MIR93 0.43 5.73 0.3 2.31e-8 Coronary artery disease; CRC trans rs10242455 0.867 rs45624139 chr7:99319495 T/C cg09045935 chr12:6379348 NA 0.61 6.06 0.32 3.65e-9 Blood metabolite levels; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg04318602 chr14:53162623 ERO1L 0.44 7.34 0.38 1.7e-12 Liver disease severity in Alagille syndrome; CRC cis rs12540874 0.663 rs1451371 chr7:50553051 T/C cg14593290 chr7:50529359 DDC -0.49 -7.0 -0.36 1.42e-11 Systemic sclerosis; CRC cis rs754466 0.606 rs11002310 chr10:79596030 A/C cg26805224 chr10:79626177 DLG5 -0.48 -6.96 -0.36 1.81e-11 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs9394438 0.628 rs4714079 chr6:37544439 C/T cg00985040 chr6:37553208 NA -0.39 -6.48 -0.34 3.27e-10 IgG glycosylation; CRC cis rs6088580 0.634 rs4142007 chr20:32990050 G/T cg08999081 chr20:33150536 PIGU -0.62 -11.47 -0.53 7.71e-26 Glomerular filtration rate (creatinine); CRC cis rs10504229 0.679 rs7839948 chr8:58130607 A/G cg02725872 chr8:58115012 NA -0.64 -11.55 -0.54 3.85e-26 Developmental language disorder (linguistic errors); CRC trans rs57221529 0.709 rs4957056 chr5:570105 T/C cg25482853 chr8:67687455 SGK3 1.23 15.4 0.65 1.15e-40 Lung disease severity in cystic fibrosis; CRC cis rs7666738 0.830 rs11944035 chr4:98931618 C/T cg17366294 chr4:99064904 C4orf37 0.43 7.32 0.37 1.95e-12 Colonoscopy-negative controls vs population controls; CRC cis rs11792861 0.926 rs12683988 chr9:111867290 T/C cg05043794 chr9:111880884 C9orf5 -0.36 -6.55 -0.34 2.2e-10 Menarche (age at onset); CRC cis rs10504229 0.683 rs7835498 chr8:58129780 A/C cg04204079 chr8:58130323 NA -0.45 -5.78 -0.3 1.71e-8 Developmental language disorder (linguistic errors); CRC cis rs7192750 0.652 rs152828 chr16:72123886 T/C cg14768367 chr16:72042858 DHODH 0.77 6.05 0.32 3.84e-9 LDL cholesterol levels;Total cholesterol levels; CRC cis rs853679 1.000 rs1679709 chr6:28228342 A/G cg06470822 chr6:28175283 NA -0.61 -6.14 -0.32 2.42e-9 Depression; CRC cis rs4638749 0.677 rs12475343 chr2:108851373 T/C cg25838818 chr2:108905173 SULT1C2 -0.35 -5.93 -0.31 7.49e-9 Blood pressure; CRC cis rs9611565 0.765 rs132920 chr22:41810170 T/C cg06481639 chr22:41940642 POLR3H 0.5 5.82 0.31 1.41e-8 Vitiligo; CRC cis rs72945132 0.882 rs72949076 chr11:70217695 T/C cg00319359 chr11:70116639 PPFIA1 0.65 6.89 0.36 2.78e-11 Coronary artery disease; CRC cis rs9300255 0.722 rs12322888 chr12:123825559 A/G cg00376283 chr12:123451042 ABCB9 0.54 7.13 0.37 6.4e-12 Neutrophil percentage of white cells; CRC cis rs8141529 0.764 rs5752807 chr22:29223169 A/G cg15103426 chr22:29168792 CCDC117 0.58 8.44 0.42 1.04e-15 Lymphocyte counts; CRC trans rs4689592 0.503 rs11937667 chr4:7057037 C/G cg07817883 chr1:32538562 TMEM39B 0.69 7.62 0.39 2.75e-13 Monocyte percentage of white cells; CRC cis rs13064411 0.696 rs2399479 chr3:113227050 G/A cg10517650 chr3:113235015 CCDC52 -0.41 -7.05 -0.36 1.04e-11 Response to simvastatin treatment (PCSK9 protein level change); CRC cis rs6500395 0.889 rs2080507 chr16:48688634 T/A cg04672837 chr16:48644449 N4BP1 -0.45 -6.63 -0.34 1.38e-10 Response to tocilizumab in rheumatoid arthritis; CRC cis rs853679 0.517 rs35512245 chr6:28079953 T/C cg12273811 chr6:28175739 NA 0.73 9.16 0.45 5.52e-18 Depression; CRC cis rs7772486 0.875 rs864390 chr6:146315035 G/T cg23711669 chr6:146136114 FBXO30 0.6 9.96 0.48 1.31e-20 Lobe attachment (rater-scored or self-reported); CRC cis rs6831352 0.879 rs2602888 chr4:100041706 C/T cg13256891 chr4:100009986 ADH5 0.64 8.64 0.43 2.5e-16 Alcohol dependence; CRC cis rs8010715 0.636 rs3825584 chr14:24587639 C/T cg23112188 chr14:24563095 PCK2 -0.37 -6.91 -0.36 2.57e-11 IgG glycosylation; CRC cis rs6496667 1.000 rs1971898 chr15:90890836 C/G cg04176472 chr15:90893244 GABARAPL3 0.53 8.15 0.41 7.58e-15 Rheumatoid arthritis; CRC cis rs10504229 1.000 rs67594249 chr8:58180521 T/A cg01721255 chr8:58191610 C8orf71 0.49 6.17 0.32 2e-9 Developmental language disorder (linguistic errors); CRC trans rs9291683 0.632 rs12508991 chr4:10041104 C/T cg26043149 chr18:55253948 FECH 0.53 8.17 0.41 6.79e-15 Bone mineral density; CRC cis rs6662572 0.737 rs77017199 chr1:46532407 G/A cg08644498 chr1:46502608 NA 0.42 6.48 0.34 3.29e-10 Blood protein levels; CRC cis rs6424115 0.708 rs13551 chr1:24180962 T/C cg15997130 chr1:24165203 NA -0.62 -8.09 -0.41 1.2e-14 Immature fraction of reticulocytes; CRC trans rs7395662 0.591 rs10838968 chr11:48595046 A/G cg00717180 chr2:96193071 NA -0.37 -6.11 -0.32 2.77e-9 HDL cholesterol; CRC cis rs7959452 0.590 rs11177644 chr12:69785748 A/G cg22834771 chr12:69754056 YEATS4 -0.53 -7.87 -0.4 5.15e-14 Blood protein levels; CRC cis rs6831352 0.589 rs2602836 chr4:100014805 C/T cg12011299 chr4:100065546 ADH4 -0.62 -15.03 -0.64 3.08e-39 Alcohol dependence; CRC cis rs17345786 1.000 rs3762729 chr3:101308874 C/T cg12386194 chr3:101231763 SENP7 0.52 6.74 0.35 7.13e-11 Colonoscopy-negative controls vs population controls; CRC cis rs8067545 0.641 rs203460 chr17:19815286 G/C cg04132472 chr17:19861366 AKAP10 0.44 6.86 0.35 3.48e-11 Schizophrenia; CRC trans rs10411161 0.702 rs7250193 chr19:52385520 C/T cg22319618 chr22:45562946 NUP50 0.6 6.95 0.36 1.91e-11 Breast cancer; CRC cis rs11585357 0.947 rs3003441 chr1:17611869 C/T cg08277548 chr1:17600880 PADI3 0.67 9.25 0.45 2.84e-18 Hair shape; CRC cis rs311392 0.554 rs2013501 chr8:55104313 A/G cg06042504 chr8:55087323 NA -0.36 -5.72 -0.3 2.45e-8 Pelvic organ prolapse (moderate/severe); CRC cis rs919433 0.927 rs1429412 chr2:198190894 A/G cg03934865 chr2:198174659 NA -0.4 -6.09 -0.32 3.09e-9 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC cis rs2455601 0.608 rs59025804 chr11:8870301 T/C cg09997546 chr11:8931473 C11orf17;ST5 -0.39 -5.81 -0.31 1.47e-8 Schizophrenia; CRC cis rs12477438 0.834 rs1563107 chr2:99701276 A/G cg14399236 chr2:99771627 LIPT1;TSGA10 0.61 8.58 0.43 3.91e-16 Chronic sinus infection; CRC trans rs61931739 0.500 rs11053140 chr12:34316122 T/C cg26384229 chr12:38710491 ALG10B 0.56 7.12 0.37 6.76e-12 Morning vs. evening chronotype; CRC cis rs172166 0.652 rs476167 chr6:28065888 T/C cg02683197 chr6:28174875 NA 0.67 9.18 0.45 4.91e-18 Cardiac Troponin-T levels; CRC cis rs9487051 0.768 rs437779 chr6:109527691 T/G cg21918786 chr6:109611834 NA -0.35 -5.93 -0.31 7.65e-9 Reticulocyte fraction of red cells; CRC cis rs9443645 0.901 rs2174739 chr6:79659170 C/T cg05283184 chr6:79620031 NA 0.56 8.66 0.43 2.16e-16 Intelligence (multi-trait analysis); CRC cis rs11212617 1.000 rs573890 chr11:108251363 C/G cg14761454 chr11:108092087 ATM;NPAT -0.4 -6.05 -0.32 3.99e-9 Response to metformin in type 2 diabetes (glycemic); CRC cis rs250677 0.687 rs250679 chr5:148434952 A/T cg23229984 chr5:148520753 ABLIM3 -0.44 -5.89 -0.31 9.41e-9 Breast cancer; CRC cis rs4862750 0.872 rs6811837 chr4:187898162 G/A cg10295955 chr4:187884368 NA -1.07 -28.55 -0.84 4.63e-91 Lobe attachment (rater-scored or self-reported); CRC cis rs1799949 1.000 rs35070007 chr17:41316747 C/G cg23758822 chr17:41437982 NA -0.86 -15.97 -0.66 6.87e-43 Menopause (age at onset); CRC cis rs4481887 0.636 rs4397683 chr1:248411089 C/T cg13385794 chr1:248469461 NA 0.33 5.7 0.3 2.67e-8 Common traits (Other); CRC cis rs1448094 0.967 rs7301496 chr12:86321212 A/C cg19622623 chr12:86230825 RASSF9 -0.35 -5.69 -0.3 2.83e-8 Major depressive disorder; CRC cis rs62244186 0.748 rs12635624 chr3:44678498 G/A cg15687855 chr3:44754131 ZNF502 -0.34 -5.69 -0.3 2.84e-8 Depressive symptoms; CRC cis rs1971762 0.583 rs12810378 chr12:54091838 G/T cg06632207 chr12:54070931 ATP5G2 0.37 6.24 0.33 1.32e-9 Height; CRC cis rs282587 0.569 rs395246 chr13:113415392 C/A cg04656015 chr13:113407548 ATP11A 0.59 7.56 0.38 3.96e-13 Glycated hemoglobin levels; CRC cis rs5769707 0.967 rs5769698 chr22:49997706 A/G cg20744362 chr22:50050164 C22orf34 0.3 6.03 0.32 4.51e-9 Monocyte count;Monocyte percentage of white cells; CRC cis rs9837602 0.507 rs1718244 chr3:99512608 C/T cg08350549 chr3:99591722 C3orf26;FILIP1L;MIR548G -0.39 -6.03 -0.32 4.52e-9 Breast cancer; CRC cis rs2430307 0.518 rs67763033 chr7:76517677 A/G cg15770687 chr7:76625569 PMS2L11 0.66 6.47 0.34 3.49e-10 Body mass index (joint analysis main effects and physical activity interaction);Body mass index;Body mass index in physically active individuals; CRC cis rs2075371 1.000 rs1868783 chr7:133975087 A/G cg02659138 chr7:134003124 SLC35B4 0.36 6.19 0.32 1.76e-9 Mean platelet volume; CRC trans rs6716963 0.597 rs34518729 chr2:194452807 A/T cg00362665 chr19:19370064 HAPLN4 -0.35 -5.97 -0.31 6.03e-9 Schizophrenia; CRC cis rs10744422 1.000 rs7972447 chr12:123354545 C/G cg25930673 chr12:123319894 HIP1R -0.54 -5.91 -0.31 8.5e-9 Schizophrenia; CRC cis rs9326248 0.574 rs1263173 chr11:116681008 C/T cg26566898 chr11:117069891 TAGLN 0.27 5.85 0.31 1.18e-8 Blood protein levels; CRC cis rs4975709 0.569 rs2077269 chr5:1863506 C/T cg20790798 chr5:1857306 NA -0.46 -7.1 -0.36 7.94e-12 Cardiovascular disease risk factors; CRC cis rs477895 0.653 rs66648159 chr11:63899429 G/A cg05016508 chr11:63871570 FLRT1;MACROD1 0.53 6.83 0.35 4.22e-11 Mean platelet volume; CRC cis rs34172651 0.583 rs4787649 chr16:24700215 C/T cg00339695 chr16:24857497 SLC5A11 -0.36 -7.46 -0.38 7.99e-13 Intelligence (multi-trait analysis); CRC cis rs10504229 0.635 rs72649130 chr8:58053810 G/T cg11062466 chr8:58055876 NA 0.59 7.23 0.37 3.38e-12 Developmental language disorder (linguistic errors); CRC cis rs6502050 0.842 rs7218075 chr17:80076808 C/G cg11859384 chr17:80120422 CCDC57 0.37 5.82 0.31 1.43e-8 Life satisfaction; CRC trans rs7824557 0.510 rs2736297 chr8:11234885 C/G cg06636001 chr8:8085503 FLJ10661 -0.46 -6.88 -0.35 3.04e-11 Retinal vascular caliber; CRC cis rs7937682 0.924 rs10891284 chr11:111527737 T/C cg19812747 chr11:111475976 SIK2 -0.58 -10.08 -0.49 5.38e-21 Primary sclerosing cholangitis; CRC cis rs7799006 0.657 rs10447540 chr7:2301484 A/G cg08027265 chr7:2291960 NA -0.44 -7.27 -0.37 2.58e-12 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs6499255 0.904 rs74029403 chr16:69710472 A/C cg05250797 chr16:70222502 NA 0.42 5.65 0.3 3.45e-8 IgE levels; CRC cis rs6952808 0.717 rs10950422 chr7:1926577 T/C cg22963979 chr7:1858916 MAD1L1 -0.46 -7.46 -0.38 7.85e-13 Bipolar disorder and schizophrenia; CRC cis rs17155006 0.651 rs416811 chr7:107724047 G/C cg05962710 chr7:107745446 LAMB4 -0.36 -5.85 -0.31 1.17e-8 Pneumococcal bacteremia; CRC cis rs3785574 0.962 rs57553639 chr17:61848499 C/T cg06873352 chr17:61820015 STRADA 0.5 8.04 0.41 1.68e-14 Height; CRC cis rs12024301 0.557 rs10911392 chr1:183617311 T/A cg11505048 chr1:183622726 RGL1;APOBEC4 0.81 7.12 0.37 6.85e-12 Peripheral arterial disease (traffic-related air pollution interaction); CRC trans rs66573146 0.901 rs55882710 chr4:7030704 G/A cg07817883 chr1:32538562 TMEM39B 1.27 11.15 0.52 1.07e-24 Granulocyte percentage of myeloid white cells; CRC cis rs9659323 1.000 rs56897173 chr1:119515732 G/A cg26570165 chr1:119541833 NA -0.38 -6.42 -0.33 4.63e-10 Body mass index; CRC cis rs9399135 0.869 rs9402675 chr6:135325794 C/G cg24558204 chr6:135376177 HBS1L 0.51 8.11 0.41 1.01e-14 Red blood cell count; CRC cis rs225245 0.782 rs321599 chr17:33905745 C/T cg05299278 chr17:33885742 SLFN14 0.49 7.89 0.4 4.49e-14 Reticulocyte count;Reticulocyte fraction of red cells;High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells; CRC cis rs2404602 1.000 rs12594212 chr15:76802014 T/A cg22467129 chr15:76604101 ETFA -0.4 -6.75 -0.35 6.61e-11 Blood metabolite levels; CRC cis rs2070488 0.775 rs2070489 chr3:38519424 A/G cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.77 13.54 0.6 1.74e-33 Electrocardiographic conduction measures; CRC cis rs4731207 0.672 rs2896360 chr7:124448516 T/C cg23710748 chr7:124431027 NA 0.37 5.96 0.31 6.53e-9 Cutaneous malignant melanoma; CRC cis rs875971 0.516 rs6945322 chr7:65336056 T/C cg02869306 chr7:64672164 INTS4L1 -0.35 -5.86 -0.31 1.1e-8 Aortic root size; CRC cis rs12541335 0.639 rs11135995 chr8:22200148 C/T cg27266060 chr8:22091797 NA -0.36 -6.04 -0.32 4.12e-9 Hypertriglyceridemia; CRC cis rs1552244 0.554 rs3732965 chr3:10048760 A/C cg08888203 chr3:10149979 C3orf24 0.48 7.29 0.37 2.31e-12 Alzheimer's disease; CRC cis rs7605827 0.930 rs12692266 chr2:15572380 T/C cg19274914 chr2:15703543 NA 0.39 5.86 0.31 1.15e-8 Educational attainment (years of education); CRC cis rs8031584 0.541 rs2955797 chr15:31210981 A/G cg08704250 chr15:31115839 NA 0.31 5.76 0.3 1.95e-8 Huntington's disease progression; CRC cis rs2839186 0.596 rs4819217 chr21:47644092 G/T cg20399509 chr21:47717575 C21orf57 -0.34 -5.71 -0.3 2.56e-8 Testicular germ cell tumor; CRC cis rs9902453 0.868 rs9890075 chr17:28470464 C/A cg26525008 chr17:28256777 EFCAB5;SSH2 0.68 11.1 0.52 1.55e-24 Coffee consumption (cups per day); CRC cis rs10479542 0.583 rs4131080 chr5:179044292 G/A cg19723775 chr5:179050963 HNRNPH1 0.5 7.0 0.36 1.42e-11 Lung cancer; CRC cis rs9462846 0.658 rs9471970 chr6:42913646 G/A cg02353165 chr6:42928485 GNMT 0.62 9.16 0.45 5.49e-18 Blood protein levels; CRC cis rs861020 0.606 rs689210 chr1:210013723 A/C cg05527609 chr1:210001259 C1orf107 0.81 11.25 0.53 4.61e-25 Orofacial clefts; CRC trans rs7613875 0.641 rs2624845 chr3:50062437 C/A cg21665057 chr3:196295764 WDR53;FBXO45 -0.44 -6.4 -0.33 5.49e-10 Body mass index; CRC cis rs514406 0.570 rs1332776 chr1:53189816 C/T cg24675658 chr1:53192096 ZYG11B -0.73 -11.79 -0.54 5.35e-27 Monocyte count; CRC cis rs1144713 0.531 rs2683491 chr12:32250865 A/T cg01321189 chr12:32259338 BICD1 0.5 7.04 0.36 1.1e-11 Obesity-related traits; CRC cis rs11958404 0.932 rs72816543 chr5:157416464 A/G cg05962755 chr5:157440814 NA 0.95 12.54 0.57 9.76e-30 IgG glycosylation; CRC cis rs853679 1.000 rs9986596 chr6:28219661 G/A cg15845792 chr6:28175446 NA 0.76 7.42 0.38 9.81e-13 Depression; CRC trans rs9329221 0.537 rs12678797 chr8:9978919 A/G cg06636001 chr8:8085503 FLJ10661 -0.5 -7.37 -0.38 1.43e-12 Neuroticism; CRC cis rs7927771 0.832 rs10838704 chr11:47424717 T/C cg20307385 chr11:47447363 PSMC3 -0.62 -8.72 -0.43 1.4e-16 Subjective well-being; CRC cis rs478304 0.903 rs1151502 chr11:65503485 G/C cg27068330 chr11:65405492 SIPA1 0.43 6.35 0.33 7.22e-10 Acne (severe); CRC cis rs7937682 0.575 rs7124696 chr11:111747297 A/G cg19812747 chr11:111475976 SIK2 0.42 6.26 0.33 1.22e-9 Primary sclerosing cholangitis; CRC cis rs10504229 1.000 rs66796009 chr8:58174529 G/A cg05313129 chr8:58192883 C8orf71 -0.47 -7.01 -0.36 1.37e-11 Developmental language disorder (linguistic errors); CRC cis rs868943 0.714 rs1999930 chr6:116387134 C/T cg05304507 chr6:116381966 FRK 0.28 6.44 0.33 4.3e-10 Total cholesterol levels; CRC cis rs4268898 0.722 rs7563958 chr2:24422381 C/A cg06627628 chr2:24431161 ITSN2 0.51 7.52 0.38 5.31e-13 Asthma; CRC trans rs8002861 0.905 rs12429722 chr13:44412466 T/A cg12856521 chr11:46389249 DGKZ -0.43 -6.86 -0.35 3.47e-11 Leprosy; CRC cis rs9611519 0.894 rs9611488 chr22:41462592 G/T cg06634786 chr22:41940651 POLR3H -0.44 -5.7 -0.3 2.66e-8 Neuroticism; CRC cis rs2404602 0.647 rs11072636 chr15:77185786 A/G cg23625390 chr15:77176239 SCAPER -0.86 -13.61 -0.6 9.01e-34 Blood metabolite levels; CRC cis rs4713118 0.869 rs6902689 chr6:27709441 C/T cg26587870 chr6:27730563 NA -0.44 -6.78 -0.35 5.42e-11 Parkinson's disease; CRC cis rs7666738 0.791 rs1896156 chr4:99020882 C/G cg17366294 chr4:99064904 C4orf37 0.43 7.29 0.37 2.28e-12 Colonoscopy-negative controls vs population controls; CRC cis rs4073416 0.542 rs11158604 chr14:66094450 G/A cg03016385 chr14:66212404 NA -0.45 -6.2 -0.32 1.67e-9 N-glycan levels; CRC cis rs7552404 0.731 rs5745458 chr1:76345429 G/A cg10523679 chr1:76189770 ACADM -0.68 -8.41 -0.42 1.26e-15 Blood metabolite levels;Acylcarnitine levels; CRC cis rs7659604 0.689 rs59131059 chr4:122666357 C/T cg19748678 chr4:122722346 EXOSC9 0.55 8.67 0.43 2.02e-16 Type 2 diabetes; CRC cis rs6952808 1.000 rs4449693 chr7:1884630 G/C cg20295408 chr7:1910781 MAD1L1 -0.46 -6.36 -0.33 6.81e-10 Bipolar disorder and schizophrenia; CRC cis rs9457247 1.000 rs408080 chr6:167392522 T/C cg23791538 chr6:167370224 RNASET2 -0.37 -5.75 -0.3 2.06e-8 Crohn's disease; CRC cis rs3849570 0.925 rs9841087 chr3:81907949 A/G cg07356753 chr3:81810745 GBE1 -0.64 -9.36 -0.46 1.32e-18 Waist circumference;Body mass index; CRC cis rs9915657 0.660 rs982534 chr17:70081366 T/G cg09344028 chr17:70110421 NA 0.5 7.38 0.38 1.32e-12 Thyroid hormone levels; CRC cis rs7465272 0.530 rs10103161 chr8:143738571 A/G cg10596483 chr8:143751796 JRK 0.48 6.5 0.34 2.89e-10 Bipolar disorder and schizophrenia; CRC cis rs1552244 0.882 rs9312044 chr3:10037481 T/C cg16606324 chr3:10149918 C3orf24 0.6 8.18 0.41 6.05e-15 Alzheimer's disease; CRC cis rs853679 0.517 rs9295758 chr6:28120663 C/G cg18032046 chr6:28092343 ZSCAN16 -0.51 -5.93 -0.31 7.47e-9 Depression; CRC cis rs9549260 0.755 rs4325426 chr13:41216437 C/A cg21288729 chr13:41239152 FOXO1 0.48 7.56 0.38 4.07e-13 Red blood cell count; CRC cis rs2228479 0.764 rs7186976 chr16:89961593 A/G cg04013166 chr16:89971882 TCF25 0.59 6.52 0.34 2.68e-10 Skin colour saturation; CRC cis rs1799949 1.000 rs33946455 chr17:41321846 C/T cg19454999 chr17:41278357 BRCA1;NBR2 0.55 8.65 0.43 2.24e-16 Menopause (age at onset); CRC cis rs1552244 1.000 rs7619340 chr3:10108178 C/T cg16606324 chr3:10149918 C3orf24 0.71 9.38 0.46 1.1e-18 Alzheimer's disease; CRC cis rs6502050 0.835 rs35070385 chr17:80128447 G/A cg13198984 chr17:80129470 CCDC57 0.46 8.13 0.41 9e-15 Life satisfaction; CRC cis rs9914988 0.943 rs9908881 chr17:27100924 T/A cg20469991 chr17:27169893 C17orf63 -0.6 -7.27 -0.37 2.59e-12 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC trans rs7267979 1.000 rs2482927 chr20:25327151 T/C cg17903999 chr18:56338584 MALT1 0.42 6.71 0.35 8.69e-11 Liver enzyme levels (alkaline phosphatase); CRC cis rs17270561 0.553 rs6456696 chr6:25741408 A/G cg17691542 chr6:26056736 HIST1H1C 0.72 9.24 0.45 3.07e-18 Iron status biomarkers; CRC cis rs780094 0.500 rs6760250 chr2:27812252 G/A cg27432699 chr2:27873401 GPN1 0.48 6.33 0.33 8.08e-10 Calcium levels;Fasting blood insulin;Metabolic traits;Triglyceride levels;Fasting plasma glucose;Urate levels in overweight individuals;Urate levels in obese individuals;Uric acid levels;Height;Age-related diseases, mortality and associated endophenotypes;Renal underexcretion gout;Fasting blood glucose (BMI interaction);Urate levels;Gondoic acid (20:1n-9) levels;Fasting blood insulin (BMI interaction);Triglycerides;Plasma omega-3 polyunsaturated fatty acid levels (docosapentaenoic acid);Type 2 diabetes;Nonalcoholic fatty liver disease;Hypertriglyceridemia;C-reactive protein;Age-related disease endophenotypes;LDL cholesterol;Metabolic syndrome;Crohn's disease;Alcohol consumption (drinks per week);Homeostasis model assessment of insulin resistance;Alcohol consumption;Red blood cell count;Fasting blood glucose; CRC cis rs6964587 1.000 rs4727267 chr7:91570290 G/C cg17063962 chr7:91808500 NA -0.78 -13.48 -0.6 2.8e-33 Breast cancer; CRC cis rs6840360 0.571 rs62327278 chr4:152558790 G/C cg09659197 chr4:152720779 NA 0.33 5.76 0.3 1.92e-8 Intelligence (multi-trait analysis); CRC cis rs892961 1.000 rs2164449 chr17:75401190 G/A cg05865280 chr17:75406074 SEPT9 0.63 13.98 0.61 3.61e-35 Airflow obstruction; CRC cis rs10944 0.598 rs559088 chr5:78275931 G/C cg13121490 chr5:78280331 ARSB -0.46 -6.75 -0.35 6.56e-11 Blood and toenail selenium levels; CRC trans rs3008870 0.583 rs2031495 chr1:67421714 G/T cg01448155 chr10:3564782 NA -0.5 -6.09 -0.32 3.23e-9 Lymphocyte percentage of white cells; CRC cis rs3741151 1.000 rs3741149 chr11:73021084 A/G cg17517138 chr11:73019481 ARHGEF17 -0.7 -7.34 -0.38 1.68e-12 GIP levels in response to oral glucose tolerance test (120 minutes); CRC cis rs1707322 1.000 rs10890360 chr1:46338444 C/T cg03146154 chr1:46216737 IPP 0.5 6.97 0.36 1.7e-11 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC trans rs9825823 0.617 rs2083264 chr3:61074229 A/G cg26585868 chr7:149322723 ZNF767 0.4 6.03 0.32 4.48e-9 Depressive symptom measurement or major depressive disorder; CRC cis rs12586317 0.547 rs12435454 chr14:35466997 A/G cg05294307 chr14:35346193 BAZ1A -0.73 -8.21 -0.41 5.01e-15 Psoriasis; CRC cis rs10791097 0.694 rs10791103 chr11:130757161 G/A cg12179176 chr11:130786555 SNX19 0.75 12.42 0.56 2.62e-29 Autism spectrum disorder or schizophrenia;Schizophrenia; CRC cis rs644799 1.000 rs474252 chr11:95619292 G/C cg03916912 chr11:95522834 CEP57;FAM76B 0.95 17.85 0.7 2.61e-50 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs6693567 0.586 rs4970979 chr1:150483840 C/T cg04165759 chr1:150448943 RPRD2 0.35 5.62 0.3 4.04e-8 Migraine; CRC cis rs6424115 0.830 rs2502994 chr1:24199363 T/C cg15997130 chr1:24165203 NA 0.72 10.6 0.5 9.06e-23 Immature fraction of reticulocytes; CRC trans rs10504229 1.000 rs67188507 chr8:58187492 A/T cg04077850 chr5:125800366 GRAMD3 0.37 6.27 0.33 1.15e-9 Developmental language disorder (linguistic errors); CRC cis rs853679 0.517 rs9393885 chr6:28050009 A/T cg12172441 chr6:28176163 NA 0.6 7.27 0.37 2.64e-12 Depression; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg11830880 chr17:34136324 TAF15 0.49 6.34 0.33 7.51e-10 Thyroid stimulating hormone; CRC cis rs7119 0.717 rs12898281 chr15:77786903 C/T cg05673287 chr15:77411982 SGK269 0.52 7.93 0.4 3.47e-14 Type 2 diabetes; CRC cis rs7312933 0.703 rs11181378 chr12:42600658 T/C cg11827402 chr12:42719852 PPHLN1;ZCRB1 0.65 9.05 0.45 1.31e-17 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg07926482 chr16:84651521 COTL1 0.38 6.16 0.32 2.14e-9 Liver disease severity in Alagille syndrome; CRC cis rs6424115 0.733 rs2502996 chr1:24199041 T/C cg10978503 chr1:24200527 CNR2 0.62 11.31 0.53 2.82e-25 Immature fraction of reticulocytes; CRC cis rs7224685 0.501 rs781827 chr17:3962965 G/A cg09695851 chr17:3907499 NA 0.76 14.41 0.62 8.08e-37 Type 2 diabetes; CRC cis rs9322193 0.923 rs9285524 chr6:150015258 G/A cg07701084 chr6:150067640 NUP43 0.47 6.71 0.35 8.37e-11 Lung cancer; CRC cis rs921968 0.565 rs2059717 chr2:219600316 A/T cg02176678 chr2:219576539 TTLL4 -0.42 -6.4 -0.33 5.25e-10 Mean corpuscular hemoglobin concentration; CRC cis rs11123170 0.640 rs2863240 chr2:113970116 C/T cg12889195 chr2:113992843 PAX8;LOC440839;LOC654433 -0.58 -7.74 -0.39 1.26e-13 Renal function-related traits (BUN); CRC cis rs2227631 0.505 rs6955537 chr7:100759727 A/G cg18465962 chr7:100767262 NA -0.57 -7.79 -0.39 8.85e-14 Plasminogen activator inhibitor type 1 levels (PAI-1); CRC trans rs7615952 0.932 rs13321217 chr3:125631771 G/A cg07211511 chr3:129823064 LOC729375 -1.1 -17.93 -0.7 1.29e-50 Blood pressure (smoking interaction); CRC cis rs9612 0.948 rs12609056 chr19:44258702 G/T cg08581076 chr19:44259116 C19orf61 0.52 6.78 0.35 5.7e-11 Exhaled nitric oxide output; CRC cis rs7044106 0.708 rs959558 chr9:123368911 C/G cg14255062 chr9:123606675 PSMD5;LOC253039 0.41 6.27 0.33 1.15e-9 Hip circumference adjusted for BMI; CRC cis rs6681460 1.000 rs6680944 chr1:67122565 A/T cg02459107 chr1:67143332 SGIP1 0.48 8.35 0.42 1.92e-15 Presence of antiphospholipid antibodies; CRC cis rs970548 0.954 rs7076198 chr10:45996309 C/T cg15590007 chr10:45870220 ALOX5 0.48 6.04 0.32 4.24e-9 Total cholesterol levels;Cholesterol, total;HDL cholesterol;HDL cholesterol levels; CRC cis rs1348850 0.567 rs3770012 chr2:178538023 A/G cg02961200 chr2:178257176 LOC100130691;AGPS -0.53 -7.36 -0.38 1.44e-12 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs6840360 0.642 rs6851814 chr4:152346437 G/A cg09659197 chr4:152720779 NA 0.34 6.67 0.35 1.06e-10 Intelligence (multi-trait analysis); CRC cis rs17711722 0.522 rs62469933 chr7:65265639 G/A cg18876405 chr7:65276391 NA 0.53 8.88 0.44 4.46e-17 Calcium levels; CRC cis rs1008375 1.000 rs28497813 chr4:17685503 A/G cg16339924 chr4:17578868 LAP3 0.53 7.2 0.37 4.23e-12 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs873946 0.586 rs3793686 chr10:134569559 A/G cg27286337 chr10:134555280 INPP5A 0.68 8.53 0.43 5.4e-16 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CRC cis rs6570726 0.764 rs9322028 chr6:145895797 G/T cg23711669 chr6:146136114 FBXO30 0.69 11.52 0.54 4.94e-26 Lobe attachment (rater-scored or self-reported); CRC cis rs6860806 0.661 rs6890009 chr5:131580033 G/T cg18758796 chr5:131593413 PDLIM4 0.42 7.67 0.39 2.02e-13 Breast cancer; CRC cis rs62458065 0.513 rs7788809 chr7:32552622 T/A cg20159608 chr7:32802032 NA -0.62 -7.79 -0.39 8.77e-14 Metabolite levels (HVA/MHPG ratio); CRC cis rs9905704 0.918 rs72828707 chr17:56883236 A/G cg12560992 chr17:57184187 TRIM37 0.52 7.27 0.37 2.56e-12 Testicular germ cell tumor; CRC cis rs4243830 0.850 rs932112 chr1:6591937 A/G cg22792644 chr1:6614718 TAS1R1;NOL9 -0.81 -9.8 -0.48 4.78e-20 Body mass index; CRC cis rs372883 0.638 rs117213 chr21:30720536 G/A cg08807101 chr21:30365312 RNF160 -0.56 -7.81 -0.4 7.96e-14 Pancreatic cancer; CRC cis rs6496932 0.563 rs2344083 chr15:85897432 T/A cg12701268 chr15:85882886 NA -0.46 -7.42 -0.38 9.86e-13 Central corneal thickness;Corneal structure; CRC cis rs67311347 1.000 rs12633431 chr3:40505740 C/T cg09455208 chr3:40491958 NA -0.48 -9.49 -0.46 4.92e-19 Renal cell carcinoma; CRC cis rs5753618 0.583 rs5753628 chr22:31860322 A/G cg22777020 chr22:31556080 RNF185 0.46 5.61 0.3 4.21e-8 Colorectal cancer; CRC cis rs9287719 0.649 rs10929683 chr2:10732208 C/T cg00105475 chr2:10696890 NA -0.45 -7.07 -0.36 9.3e-12 Prostate cancer; CRC cis rs9814567 1.000 rs1880377 chr3:134270468 T/C cg06109529 chr3:134205091 CEP63;ANAPC13 0.82 12.06 0.55 5.69e-28 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs760805 0.965 rs4648883 chr1:25261203 T/C cg22509179 chr1:25234806 RUNX3 -0.6 -9.52 -0.46 3.88e-19 Allergic disease (asthma, hay fever or eczema); CRC cis rs728616 0.867 rs118134654 chr10:81744381 G/A cg11900509 chr10:81946545 ANXA11 -0.68 -6.77 -0.35 5.99e-11 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs637571 0.510 rs10896052 chr11:65579600 C/A cg26695010 chr11:65641043 EFEMP2 0.48 7.43 0.38 9.26e-13 Eosinophil percentage of white cells; CRC cis rs9660180 0.967 rs6603803 chr1:1812688 A/G cg13866156 chr1:1669148 SLC35E2 -0.61 -9.46 -0.46 5.98e-19 Body mass index; CRC cis rs875971 0.895 rs778700 chr7:65866450 C/T cg18912574 chr7:65842487 NCRNA00174 0.36 6.18 0.32 1.88e-9 Aortic root size; CRC trans rs7615952 0.546 rs11717632 chr3:125321130 G/C cg21747405 chr11:67723411 NA -0.5 -6.24 -0.33 1.34e-9 Blood pressure (smoking interaction); CRC cis rs1949733 0.598 rs869602 chr4:8535371 G/T cg13073564 chr4:8508604 NA 0.4 6.06 0.32 3.66e-9 Response to antineoplastic agents; CRC cis rs10540 0.730 rs61876338 chr11:493730 A/G cg08200582 chr11:442649 ANO9 -0.71 -7.42 -0.38 9.82e-13 Body mass index; CRC cis rs7552404 0.824 rs1251077 chr1:76189745 C/G cg10523679 chr1:76189770 ACADM -0.91 -16.51 -0.67 5.17e-45 Blood metabolite levels;Acylcarnitine levels; CRC cis rs9549367 0.789 rs34568744 chr13:113894564 G/T cg18105134 chr13:113819100 PROZ -0.71 -10.34 -0.5 7.19e-22 Platelet distribution width; CRC cis rs7777484 0.571 rs2527686 chr7:2834413 G/A cg09658497 chr7:2847517 GNA12 -0.38 -6.32 -0.33 8.56e-10 Height; CRC cis rs6502050 0.799 rs8082355 chr17:80120316 A/G cg09264619 chr17:80180166 NA -0.35 -5.93 -0.31 7.47e-9 Life satisfaction; CRC cis rs4638749 0.677 rs7594896 chr2:108835502 C/T cg25838818 chr2:108905173 SULT1C2 -0.35 -5.91 -0.31 8.58e-9 Blood pressure; CRC cis rs5769765 1.000 rs4824112 chr22:50284345 A/G cg22709217 chr22:50311962 ALG12;CRELD2 -1.03 -16.54 -0.67 3.73e-45 Schizophrenia; CRC trans rs12599106 0.660 rs12919333 chr16:34991336 C/T cg03395511 chr6:291903 DUSP22 -0.64 -8.91 -0.44 3.59e-17 Menopause (age at onset); CRC cis rs9399135 0.967 rs1014020 chr6:135334426 C/A cg22676075 chr6:135203613 NA 0.41 6.35 0.33 7.28e-10 Red blood cell count; CRC cis rs736408 0.609 rs13087772 chr3:52782274 T/G cg18404041 chr3:52824283 ITIH1 -0.43 -8.9 -0.44 3.76e-17 Bipolar disorder; CRC trans rs2303319 0.504 rs72877343 chr2:162607487 A/C cg18122310 chr12:50236657 BCDIN3D -0.73 -6.35 -0.33 7.23e-10 Cognitive function; CRC cis rs533581 0.866 rs475796 chr16:88970776 C/G cg05579598 chr16:88989069 CBFA2T3 0.35 6.99 0.36 1.5e-11 Social autistic-like traits; CRC cis rs9905704 0.918 rs304282 chr17:56785571 T/C cg12560992 chr17:57184187 TRIM37 0.54 7.62 0.39 2.77e-13 Testicular germ cell tumor; CRC cis rs12760731 0.582 rs12046110 chr1:178531117 C/T cg00404053 chr1:178313656 RASAL2 -0.61 -6.89 -0.36 2.86e-11 Obesity-related traits; CRC trans rs1814175 0.646 rs61904497 chr11:49883449 A/T cg15704280 chr7:45808275 SEPT13 -0.94 -16.65 -0.68 1.36e-45 Height; CRC cis rs7113874 0.589 rs6578969 chr11:8488991 G/A cg02811074 chr11:8615871 STK33 -0.36 -6.17 -0.32 2.04e-9 Body mass index in physically active individuals;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs12745968 0.623 rs6604007 chr1:93170564 G/A cg17283838 chr1:93427260 FAM69A -0.44 -5.99 -0.31 5.41e-9 Bipolar disorder and schizophrenia; CRC cis rs6582630 0.555 rs11610015 chr12:38508856 A/G cg26384229 chr12:38710491 ALG10B 0.69 9.84 0.48 3.41e-20 Drug-induced liver injury (flucloxacillin); CRC cis rs9549260 0.753 rs2297628 chr13:41233905 T/C cg21288729 chr13:41239152 FOXO1 0.49 6.21 0.32 1.62e-9 Red blood cell count; CRC cis rs4731207 0.596 rs12533918 chr7:124647263 C/T cg23710748 chr7:124431027 NA -0.39 -6.24 -0.33 1.35e-9 Cutaneous malignant melanoma; CRC cis rs875971 0.964 rs2161065 chr7:65932905 A/G cg18876405 chr7:65276391 NA 0.52 8.85 0.44 5.32e-17 Aortic root size; CRC cis rs1801251 1.000 rs1801251 chr2:233633460 G/A cg25237894 chr2:233734115 C2orf82 0.55 8.93 0.44 3.13e-17 Coronary artery disease; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg17159837 chr22:38864121 KDELR3 0.46 6.27 0.33 1.11e-9 Anxiety disorder; CRC trans rs2303319 0.504 rs56407015 chr2:162455625 G/A cg18122310 chr12:50236657 BCDIN3D -0.72 -6.17 -0.32 2.06e-9 Cognitive function; CRC trans rs916888 0.773 rs199457 chr17:44795469 C/T cg10053473 chr17:62856997 LRRC37A3 -0.78 -8.56 -0.43 4.25e-16 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs7605827 0.860 rs13425097 chr2:15528920 C/G cg19274914 chr2:15703543 NA 0.4 5.97 0.31 6.31e-9 Educational attainment (years of education); CRC cis rs1401999 0.659 rs4912518 chr3:183752027 C/T cg05044414 chr3:183734942 ABCC5 -0.38 -6.56 -0.34 2.14e-10 Anterior chamber depth; CRC cis rs12024301 0.557 rs75462421 chr1:183623105 C/T cg11505048 chr1:183622726 RGL1;APOBEC4 0.78 6.93 0.36 2.18e-11 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs7959452 0.901 rs1384 chr12:69747834 C/T cg22834771 chr12:69754056 YEATS4 -0.48 -7.09 -0.36 8.44e-12 Blood protein levels; CRC cis rs713477 0.618 rs6573033 chr14:55919060 C/G cg13175173 chr14:55914753 NA -0.43 -7.48 -0.38 6.98e-13 Pediatric bone mineral content (femoral neck); CRC cis rs736408 0.634 rs11717836 chr3:52807736 A/G cg05573699 chr3:52720067 GNL3;PBRM1 -0.45 -6.22 -0.32 1.53e-9 Bipolar disorder; CRC cis rs13108904 0.967 rs11247986 chr4:1294347 G/A cg00684032 chr4:1343700 KIAA1530 0.47 6.82 0.35 4.43e-11 Obesity-related traits; CRC cis rs9486719 0.895 rs3798294 chr6:97049587 G/A cg18709589 chr6:96969512 KIAA0776 -0.51 -5.81 -0.3 1.52e-8 Migraine;Coronary artery disease; CRC cis rs11098499 0.955 rs35434465 chr4:120169378 C/G cg24375607 chr4:120327624 NA 0.48 7.39 0.38 1.19e-12 Corneal astigmatism; CRC cis rs911555 0.723 rs4906324 chr14:103923099 A/G cg12935359 chr14:103987150 CKB 0.56 9.01 0.44 1.77e-17 Intelligence (multi-trait analysis); CRC cis rs4713118 0.662 rs149970 chr6:27980220 C/T cg03623178 chr6:28175578 NA 0.87 12.49 0.57 1.51e-29 Parkinson's disease; CRC cis rs12586317 0.620 rs8020370 chr14:35581432 G/A cg05294307 chr14:35346193 BAZ1A -0.61 -7.03 -0.36 1.22e-11 Psoriasis; CRC cis rs2425143 1.000 rs28685274 chr20:34358527 T/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.48 -6.17 -0.32 1.97e-9 Blood protein levels; CRC cis rs7584330 0.780 rs12474519 chr2:238377012 G/A cg16989719 chr2:238392110 NA -0.44 -8.56 -0.43 4.34e-16 Prostate cancer; CRC cis rs1448094 0.511 rs7967183 chr12:86216845 T/G cg00310523 chr12:86230176 RASSF9 0.34 5.83 0.31 1.3e-8 Major depressive disorder; CRC cis rs13108904 0.870 rs4974543 chr4:1251222 A/G cg20092199 chr4:1342459 KIAA1530 0.34 5.9 0.31 8.88e-9 Obesity-related traits; CRC cis rs62408225 0.748 rs7744528 chr6:90916931 C/G cg06866423 chr6:90926672 BACH2 0.65 12.2 0.56 1.65e-28 Eosinophil counts;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC cis rs11690935 0.550 rs7584187 chr2:172866105 A/G cg13550731 chr2:172543902 DYNC1I2 -0.61 -8.87 -0.44 4.81e-17 Schizophrenia; CRC cis rs2204008 0.654 rs1290325 chr12:38152910 C/T cg26384229 chr12:38710491 ALG10B -0.53 -7.84 -0.4 6.52e-14 Bladder cancer; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg06911519 chr2:28615662 FOSL2 0.53 6.87 0.35 3.29e-11 Thyroid stimulating hormone; CRC trans rs9409565 0.826 rs9409564 chr9:97248166 C/T cg05679027 chr9:99775184 HIATL2 -0.41 -6.22 -0.32 1.52e-9 Colorectal cancer (alcohol consumption interaction); CRC cis rs1046896 0.731 rs8067667 chr17:80785875 A/G cg17346650 chr17:80929145 B3GNTL1 0.46 6.7 0.35 8.82e-11 Glycated hemoglobin levels; CRC cis rs6860806 0.661 rs4705927 chr5:131578608 C/G cg09877947 chr5:131593287 PDLIM4 0.45 8.43 0.42 1.13e-15 Breast cancer; CRC cis rs1865760 0.593 rs3903852 chr6:25915147 G/T cg17691542 chr6:26056736 HIST1H1C 0.45 6.9 0.36 2.61e-11 Height; CRC cis rs6088813 1.000 rs6141549 chr20:33974051 T/C cg14752227 chr20:34000481 UQCC -0.36 -5.62 -0.3 3.99e-8 Height; CRC cis rs2933343 1.000 rs1683776 chr3:128622760 G/T cg11901034 chr3:128598214 ACAD9 -0.51 -6.2 -0.32 1.71e-9 IgG glycosylation; CRC cis rs6912958 0.559 rs107690 chr6:88069352 A/G cg12350822 chr6:88032061 C6orf162;GJB7 -0.43 -8.83 -0.44 6.46e-17 Monocyte percentage of white cells; CRC cis rs172166 0.694 rs203876 chr6:28046673 T/C cg02631126 chr6:28058918 ZSCAN12L1 0.24 5.67 0.3 3.09e-8 Cardiac Troponin-T levels; CRC cis rs4713118 0.628 rs9295740 chr6:27689502 G/A cg19041857 chr6:27730383 NA -0.46 -5.96 -0.31 6.49e-9 Parkinson's disease; CRC cis rs6500395 1.000 rs1909765 chr16:48597358 A/G cg04672837 chr16:48644449 N4BP1 0.44 6.47 0.34 3.65e-10 Response to tocilizumab in rheumatoid arthritis; CRC cis rs8005677 0.828 rs4981451 chr14:23410281 T/C cg25600027 chr14:23388339 RBM23 -0.43 -6.44 -0.33 4.13e-10 Cognitive ability (multi-trait analysis); CRC cis rs13118159 0.509 rs10023473 chr4:1375285 C/T cg02475777 chr4:1388615 CRIPAK 0.49 6.4 0.33 5.23e-10 Longevity; CRC trans rs1569175 0.655 rs3115414 chr2:200913244 A/C cg12143499 chr12:27615389 NA 0.68 6.02 0.31 4.75e-9 Response to treatment for acute lymphoblastic leukemia; CRC cis rs11249608 0.548 rs35568336 chr5:178451854 A/G cg01312482 chr5:178451176 ZNF879 -0.36 -6.02 -0.32 4.59e-9 Pubertal anthropometrics; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg10317628 chr1:117113342 CD58 0.54 6.93 0.36 2.18e-11 Thyroid stimulating hormone; CRC cis rs5769765 0.955 rs9616394 chr22:50314927 G/C cg04121214 chr22:50244548 NA 0.41 5.86 0.31 1.14e-8 Schizophrenia; CRC cis rs12824058 0.831 rs12829373 chr12:130814114 G/C cg24838063 chr12:130822603 PIWIL1 0.57 9.63 0.47 1.65e-19 Menopause (age at onset); CRC cis rs9926296 0.605 rs3743859 chr16:89846050 A/G cg27121462 chr16:89883253 FANCA -0.56 -9.15 -0.45 6.29e-18 Vitiligo; CRC cis rs3996993 0.809 rs59119896 chr6:52688467 G/A cg20803780 chr6:52668592 GSTA1 0.35 6.19 0.32 1.74e-9 Hemoglobin concentration; CRC cis rs2075371 0.897 rs1646743 chr7:134003451 C/A cg11752832 chr7:134001865 SLC35B4 0.49 7.66 0.39 2.06e-13 Mean platelet volume; CRC cis rs11628318 0.564 rs8013957 chr14:103140254 C/T cg12046867 chr14:103022105 NA 0.42 6.21 0.32 1.56e-9 Platelet count; CRC cis rs12936587 0.692 rs12943416 chr17:17535535 A/C cg09796270 chr17:17721594 SREBF1 -0.42 -5.92 -0.31 8.01e-9 Hip circumference;Coronary artery disease or large artery stroke;Coronary heart disease;Coronary artery disease; CRC cis rs9916302 0.904 rs600010 chr17:37433517 T/C cg15445000 chr17:37608096 MED1 0.42 9.11 0.45 7.94e-18 Glomerular filtration rate (creatinine); CRC cis rs7843479 0.601 rs6557712 chr8:21826421 C/T cg16476235 chr8:21771668 DOK2 0.37 6.44 0.33 4.13e-10 Mean corpuscular volume; CRC cis rs2075371 0.796 rs1646645 chr7:134012232 G/T cg02659138 chr7:134003124 SLC35B4 -0.39 -6.68 -0.35 1.02e-10 Mean platelet volume; CRC cis rs909002 0.800 rs6703093 chr1:32093561 C/T cg01639898 chr1:32083012 HCRTR1 0.3 6.27 0.33 1.1e-9 Intelligence (multi-trait analysis); CRC cis rs270601 0.913 rs273899 chr5:131695178 G/A cg22638593 chr5:131593259 PDLIM4 0.39 6.39 0.33 5.55e-10 Acylcarnitine levels; CRC cis rs4253772 0.591 rs113101219 chr22:46659186 C/A cg24881330 chr22:46731750 TRMU 0.64 5.9 0.31 9.08e-9 LDL cholesterol;Cholesterol, total; CRC trans rs875971 0.660 rs2191268 chr7:66110224 C/T cg19451435 chr6:158402916 SYNJ2 -0.4 -6.45 -0.34 4.1e-10 Aortic root size; CRC cis rs7523050 0.643 rs36047249 chr1:109401499 T/C cg08274380 chr1:109419600 GPSM2 0.85 6.65 0.34 1.24e-10 Fat distribution (HIV); CRC cis rs11098499 0.866 rs6857892 chr4:120282696 G/T cg24375607 chr4:120327624 NA 0.48 7.48 0.38 6.72e-13 Corneal astigmatism; CRC cis rs10504229 0.683 rs11787247 chr8:58131528 G/T cg04204079 chr8:58130323 NA -0.45 -5.78 -0.3 1.71e-8 Developmental language disorder (linguistic errors); CRC cis rs9611565 0.729 rs137831 chr22:41903813 A/C cg06634786 chr22:41940651 POLR3H -0.56 -7.25 -0.37 2.96e-12 Vitiligo; CRC cis rs7246657 0.943 rs4452075 chr19:37879589 A/G cg23950597 chr19:37808831 NA -0.49 -5.99 -0.31 5.65e-9 Coronary artery calcification; CRC cis rs7552404 0.727 rs1144336 chr1:76277421 C/A cg03433033 chr1:76189801 ACADM 0.67 9.29 0.46 2.13e-18 Blood metabolite levels;Acylcarnitine levels; CRC trans rs1814175 0.791 rs10219223 chr11:49791468 A/T cg11707556 chr5:10655725 ANKRD33B -0.42 -7.99 -0.4 2.29e-14 Height; CRC cis rs763014 0.966 rs15564 chr16:677854 G/T cg04562611 chr16:615315 C16orf11 0.39 6.72 0.35 7.88e-11 Height; CRC cis rs6665290 0.904 rs12409428 chr1:227189969 T/C cg10327440 chr1:227177885 CDC42BPA -1.04 -23.16 -0.79 4.32e-71 Myeloid white cell count; CRC trans rs1997103 1.000 rs6949244 chr7:55411301 C/G cg20935933 chr6:143382018 AIG1 0.51 6.65 0.34 1.25e-10 QRS interval (sulfonylurea treatment interaction); CRC cis rs7605827 0.930 rs7598068 chr2:15596535 A/T cg19274914 chr2:15703543 NA 0.39 5.92 0.31 8.31e-9 Educational attainment (years of education); CRC cis rs736801 0.836 rs2522052 chr5:131798487 C/T cg00255919 chr5:131827918 IRF1 0.36 6.21 0.32 1.57e-9 Breast cancer;Mosquito bite size; CRC trans rs7179994 0.579 rs55802438 chr15:28300339 G/A cg05237436 chr5:138533428 SIL1 0.7 6.28 0.33 1.1e-9 Shingles; CRC cis rs11148252 0.967 rs11620062 chr13:52994026 T/G cg00495681 chr13:53174319 NA 0.6 9.36 0.46 1.28e-18 Lewy body disease; CRC cis rs62064224 0.589 rs2344976 chr17:30685935 T/C cg25809561 chr17:30822961 MYO1D 0.52 9.19 0.45 4.5e-18 Schizophrenia; CRC cis rs3823572 0.542 rs11767663 chr7:133630596 T/C cg03336402 chr7:133662267 EXOC4 0.68 10.44 0.5 3.23e-22 Intelligence (multi-trait analysis); CRC trans rs10506458 0.915 rs17738485 chr12:63394932 T/C cg22491629 chr6:157744540 C6orf35 -0.77 -9.05 -0.45 1.31e-17 Hemostatic factors and hematological phenotypes; CRC cis rs360798 0.532 rs2421816 chr2:63075033 C/A cg17519650 chr2:63277830 OTX1 0.47 6.49 0.34 3.19e-10 Coronary artery disease; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg07464025 chr10:13482639 BEND7 0.44 7.39 0.38 1.21e-12 Liver disease severity in Alagille syndrome; CRC cis rs7680126 0.633 rs4698040 chr4:10352550 C/T cg00071950 chr4:10020882 SLC2A9 -0.5 -6.47 -0.34 3.65e-10 Urate levels in lean individuals;Urate levels in overweight individuals;Urate levels in obese individuals; CRC cis rs13064411 0.696 rs6438159 chr3:113217341 T/C cg18753928 chr3:113234510 CCDC52 -0.7 -10.83 -0.51 1.45e-23 Response to simvastatin treatment (PCSK9 protein level change); CRC cis rs9399135 0.967 rs6919862 chr6:135352443 C/A cg24558204 chr6:135376177 HBS1L 0.51 8.07 0.41 1.34e-14 Red blood cell count; CRC trans rs3806843 0.900 rs2262576 chr5:140135536 T/C cg06840491 chr10:48416966 GDF2 -0.36 -6.13 -0.32 2.56e-9 Depressive symptoms (multi-trait analysis); CRC cis rs1552244 1.000 rs7637888 chr3:10080722 T/C cg10729496 chr3:10149963 C3orf24 0.55 7.11 0.37 7.07e-12 Alzheimer's disease; CRC cis rs4625783 0.583 rs11077974 chr17:80095193 A/G cg02741985 chr17:80059408 CCDC57 0.43 7.15 0.37 5.66e-12 Blood metabolite levels; CRC cis rs703842 0.963 rs2291617 chr12:58166403 T/G cg00677455 chr12:58241039 CTDSP2 0.67 9.26 0.45 2.74e-18 Multiple sclerosis; CRC trans rs6860806 0.507 rs169256 chr5:131688533 A/G cg17154259 chr5:32444035 ZFR 0.53 6.29 0.33 1.02e-9 Breast cancer; CRC cis rs559928 0.597 rs2186572 chr11:63895887 A/G cg19465662 chr11:63993652 NUDT22;TRPT1 0.7 6.5 0.34 2.94e-10 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; CRC cis rs2976388 0.566 rs2585141 chr8:143806343 G/A cg10596483 chr8:143751796 JRK -0.46 -6.44 -0.33 4.22e-10 Urinary tract infection frequency; CRC cis rs61008539 0.893 rs7783487 chr7:860160 A/C cg00934597 chr7:893267 UNC84A -0.56 -7.84 -0.4 6.21e-14 Perceived unattractiveness to mosquitoes; CRC cis rs6964587 0.773 rs2097810 chr7:91977226 G/A cg17063962 chr7:91808500 NA 0.72 10.65 0.51 5.79e-23 Breast cancer; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg18395393 chr17:8339079 NDEL1 0.42 7.03 0.36 1.23e-11 Liver disease severity in Alagille syndrome; CRC cis rs9649465 0.846 rs13044 chr7:123322716 T/A cg03229431 chr7:123269106 ASB15 -0.36 -5.64 -0.3 3.7e-8 Migraine; CRC cis rs4478858 0.735 rs6679365 chr1:31787866 A/C cg00250761 chr1:31883323 NA 0.43 8.25 0.41 3.9e-15 Alcohol dependence; CRC cis rs4363385 0.667 rs399550 chr1:153049917 T/C cg25856811 chr1:152973957 SPRR3 -0.24 -6.58 -0.34 1.86e-10 Inflammatory skin disease; CRC cis rs7584330 0.666 rs60671275 chr2:238374318 C/A cg14458575 chr2:238380390 NA 0.9 16.4 0.67 1.32e-44 Prostate cancer; CRC cis rs875971 1.000 rs2220626 chr7:65546062 C/T cg18912574 chr7:65842487 NCRNA00174 -0.38 -6.52 -0.34 2.59e-10 Aortic root size; CRC cis rs9463078 0.702 rs9369530 chr6:45024911 G/A cg25276700 chr6:44698697 NA -0.23 -5.62 -0.3 3.99e-8 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; CRC cis rs858239 0.676 rs3807459 chr7:23389751 T/C cg00469287 chr7:23338798 C7orf30 0.42 5.79 0.3 1.63e-8 Cerebrospinal fluid biomarker levels; CRC cis rs951366 0.789 rs823121 chr1:205724302 A/G cg14159672 chr1:205819179 PM20D1 -0.71 -10.4 -0.5 4.34e-22 Menarche (age at onset); CRC cis rs11148252 0.774 rs6561666 chr13:52930045 A/G cg00495681 chr13:53174319 NA 0.64 10.17 0.49 2.62e-21 Lewy body disease; CRC cis rs10504229 0.593 rs4738567 chr8:57997033 A/C cg22535103 chr8:58192502 C8orf71 -0.48 -5.71 -0.3 2.57e-8 Developmental language disorder (linguistic errors); CRC cis rs10256972 0.552 rs2949195 chr7:1202705 G/A cg03188948 chr7:1209495 NA 0.56 8.23 0.41 4.34e-15 Longevity;Endometriosis; CRC cis rs4555082 0.957 rs3000073 chr14:105729792 G/A cg06808227 chr14:105710500 BRF1 -0.6 -9.07 -0.45 1.07e-17 Mean platelet volume;Platelet distribution width; CRC cis rs7659604 0.539 rs11098648 chr4:122759872 C/T cg20573242 chr4:122745356 CCNA2 0.57 8.49 0.42 7.19e-16 Type 2 diabetes; CRC cis rs7618915 0.547 rs4130905 chr3:52709831 A/T cg08222913 chr3:52553049 STAB1 -0.34 -6.12 -0.32 2.7e-9 Bipolar disorder; CRC cis rs6952808 0.689 rs79950306 chr7:2022063 C/G cg04267008 chr7:1944627 MAD1L1 -0.81 -11.56 -0.54 3.67e-26 Bipolar disorder and schizophrenia; CRC trans rs7027930 0.524 rs4585791 chr9:614530 T/A cg27061366 chr19:13044373 FARSA 0.47 6.02 0.31 4.62e-9 Pulmonary function decline; CRC cis rs7666738 0.830 rs28728124 chr4:99001116 G/T cg05340658 chr4:99064831 C4orf37 0.61 9.54 0.47 3.45e-19 Colonoscopy-negative controls vs population controls; CRC trans rs11800820 0.567 rs3129568 chr1:246707858 A/G cg26885821 chr6:124125002 NKAIN2 0.38 6.09 0.32 3.11e-9 Obesity-related traits; CRC cis rs3733585 0.783 rs13148371 chr4:10032561 C/T cg11266682 chr4:10021025 SLC2A9 0.53 11.11 0.52 1.46e-24 Cleft plate (environmental tobacco smoke interaction); CRC cis rs9443645 0.527 rs4706746 chr6:79674176 G/A cg05283184 chr6:79620031 NA -0.45 -6.46 -0.34 3.84e-10 Intelligence (multi-trait analysis); CRC cis rs9549328 0.670 rs61963562 chr13:113616523 T/G cg25790453 chr13:113633590 MCF2L 0.43 7.55 0.38 4.25e-13 Systolic blood pressure; CRC cis rs6076065 0.723 rs7988 chr20:23352685 C/A cg11657817 chr20:23433608 CST11 0.43 6.46 0.34 3.77e-10 Facial morphology (factor 15, philtrum width); CRC cis rs4713118 0.869 rs6901520 chr6:27714575 G/T cg06470822 chr6:28175283 NA 0.72 10.35 0.5 6.55e-22 Parkinson's disease; CRC cis rs561341 0.700 rs6505266 chr17:30225813 G/A cg00745463 chr17:30367425 LRRC37B -0.45 -6.03 -0.32 4.35e-9 Hip circumference adjusted for BMI; CRC cis rs7666738 0.753 rs17483788 chr4:98985623 G/A cg17366294 chr4:99064904 C4orf37 0.43 7.33 0.37 1.76e-12 Colonoscopy-negative controls vs population controls; CRC cis rs9611565 0.681 rs132918 chr22:41808350 C/T cg06634786 chr22:41940651 POLR3H 0.58 6.71 0.35 8.55e-11 Vitiligo; CRC cis rs477895 0.568 rs34838337 chr11:63870892 T/C cg05016508 chr11:63871570 FLRT1;MACROD1 0.59 7.9 0.4 4.3e-14 Mean platelet volume; CRC cis rs367615 0.506 rs1428932 chr5:108792479 A/G cg17395555 chr5:108820864 NA -0.42 -8.37 -0.42 1.67e-15 Colorectal cancer (SNP x SNP interaction); CRC cis rs2032447 0.831 rs9467664 chr6:26021813 A/T cg04800585 chr6:26043546 HIST1H2BB 0.57 8.36 0.42 1.76e-15 Intelligence (multi-trait analysis); CRC cis rs769267 0.930 rs3794990 chr19:19610030 A/G cg02546618 chr19:19431379 KIAA0892;SF4 0.45 6.13 0.32 2.57e-9 Tonsillectomy; CRC cis rs10905065 0.827 rs7089100 chr10:5849877 C/G cg25171089 chr10:5708825 ASB13 0.42 5.86 0.31 1.13e-8 Menopause (age at onset); CRC cis rs2832191 0.716 rs7284006 chr21:30475186 T/A cg24692254 chr21:30365293 RNF160 0.83 15.4 0.65 1.1e-40 Dental caries; CRC trans rs9826463 0.941 rs73238201 chr3:142204728 C/T cg13928417 chr9:124498782 DAB2IP -0.54 -6.47 -0.34 3.48e-10 QRS duration in Tripanosoma cruzi seropositivity; CRC cis rs9322193 0.810 rs62439811 chr6:149961552 C/T cg05861140 chr6:150128134 PCMT1 -0.37 -5.81 -0.3 1.51e-8 Lung cancer; CRC cis rs599083 0.530 rs491347 chr11:68169688 G/A cg01657329 chr11:68192670 LRP5 0.46 6.75 0.35 6.76e-11 Bone mineral density (spine); CRC trans rs9329221 0.620 rs6601427 chr8:10156025 A/G cg06636001 chr8:8085503 FLJ10661 -0.62 -9.87 -0.48 2.63e-20 Neuroticism; CRC cis rs8180040 0.966 rs807932 chr3:47354241 C/T cg27129171 chr3:47204927 SETD2 0.55 8.67 0.43 2.03e-16 Colorectal cancer; CRC cis rs742320 0.756 rs4984925 chr16:839996 T/C cg07501729 chr16:846077 CHTF18 0.56 8.39 0.42 1.44e-15 Mean corpuscular volume; CRC cis rs2072499 0.750 rs72708291 chr1:156177285 A/T cg25208724 chr1:156163844 SLC25A44 0.97 15.81 0.66 2.91e-42 Testicular germ cell tumor; CRC cis rs2976388 0.647 rs2244163 chr8:143784500 T/G cg12516270 chr8:143859308 LYNX1 0.41 7.23 0.37 3.32e-12 Urinary tract infection frequency; CRC trans rs586533 0.634 rs676649 chr11:99533358 C/T cg14135551 chr6:39760416 DAAM2 0.36 6.0 0.31 5.31e-9 Depressive symptoms (multi-trait analysis); CRC cis rs9303401 0.614 rs68100606 chr17:56500898 G/A cg10487724 chr17:56770010 TEX14;RAD51C 0.76 9.3 0.46 2.07e-18 Cognitive test performance; CRC cis rs2075371 0.863 rs1646638 chr7:134008706 T/C cg02659138 chr7:134003124 SLC35B4 0.43 7.58 0.39 3.52e-13 Mean platelet volume; CRC cis rs6089584 0.706 rs6089625 chr20:60620622 T/C cg12751644 chr20:60527061 NA -0.38 -5.84 -0.31 1.25e-8 Body mass index; CRC cis rs6912958 0.712 rs7755167 chr6:88338752 T/C cg08069147 chr6:88032118 GJB7;C6orf162 -0.57 -8.61 -0.43 3.14e-16 Monocyte percentage of white cells; CRC cis rs1448094 0.845 rs10863123 chr12:86346254 G/A cg18827107 chr12:86230957 RASSF9 -0.39 -6.32 -0.33 8.28e-10 Major depressive disorder; CRC cis rs7666738 0.924 rs13124368 chr4:99039615 T/C cg17366294 chr4:99064904 C4orf37 0.44 7.5 0.38 6.02e-13 Colonoscopy-negative controls vs population controls; CRC cis rs2576037 0.901 rs2576036 chr18:44587102 G/T cg23996704 chr18:44553084 KATNAL2 -0.3 -6.25 -0.33 1.3e-9 Personality dimensions; CRC cis rs7772486 0.686 rs2179323 chr6:145982786 T/G cg23711669 chr6:146136114 FBXO30 -0.63 -10.38 -0.5 5.12e-22 Lobe attachment (rater-scored or self-reported); CRC cis rs6543140 0.964 rs11886793 chr2:103072220 T/G cg04239558 chr2:103089729 SLC9A4 0.37 6.58 0.34 1.83e-10 Blood protein levels; CRC cis rs9372498 0.536 rs62663261 chr6:118900553 T/C cg24463073 chr6:118973353 C6orf204 0.54 7.24 0.37 3.26e-12 Diastolic blood pressure; CRC cis rs853679 0.760 rs9393910 chr6:28208192 C/G cg21251018 chr6:28226885 NKAPL 0.51 5.95 0.31 6.9e-9 Depression; CRC cis rs7727544 0.684 rs611084 chr5:131709739 A/C cg07395648 chr5:131743802 NA 0.44 6.86 0.35 3.48e-11 Blood metabolite levels; CRC cis rs6460942 0.915 rs62448594 chr7:12442229 C/G cg20607287 chr7:12443886 VWDE -0.69 -7.29 -0.37 2.4e-12 Coronary artery disease; CRC cis rs11148252 0.595 rs4885117 chr13:53153027 T/C cg00495681 chr13:53174319 NA 0.83 15.59 0.65 2e-41 Lewy body disease; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg00668182 chr20:30795591 POFUT1;PLAGL2 0.48 6.74 0.35 7.13e-11 Anxiety disorder; CRC cis rs4746818 1.000 rs4746818 chr10:70884687 G/T cg11621586 chr10:70884670 VPS26A 0.88 10.85 0.51 1.17e-23 Left atrial antero-posterior diameter; CRC trans rs853679 1.000 rs1419183 chr6:28242794 A/C cg06606381 chr12:133084897 FBRSL1 -0.64 -6.29 -0.33 1.01e-9 Depression; CRC cis rs2842992 0.789 rs3818300 chr6:160201677 G/A cg16489826 chr6:160211363 TCP1;MRPL18 0.49 6.22 0.32 1.52e-9 Age-related macular degeneration (geographic atrophy); CRC cis rs7618915 0.508 rs13065851 chr3:52644836 T/A cg11645453 chr3:52864694 ITIH4 0.36 6.27 0.33 1.14e-9 Bipolar disorder; CRC cis rs9914988 0.943 rs9894335 chr17:27138483 C/A cg16670446 chr17:27188758 MIR451;MIR144 0.57 8.94 0.44 2.76e-17 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC trans rs2055729 0.614 rs17150693 chr8:9741652 C/G cg06636001 chr8:8085503 FLJ10661 0.54 6.77 0.35 5.77e-11 Multiple myeloma (hyperdiploidy); CRC cis rs12477438 0.765 rs56167745 chr2:99600478 T/A cg26064155 chr2:99771622 LIPT1;TSGA10 -0.64 -8.83 -0.44 6.49e-17 Chronic sinus infection; CRC cis rs2739330 0.828 rs4820572 chr22:24250355 T/C cg18538332 chr22:24372958 LOC391322 -0.75 -11.85 -0.55 3.3e-27 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs2976388 0.609 rs2717602 chr8:143805683 G/A cg15511327 chr8:143859410 LYNX1 0.41 7.15 0.37 5.68e-12 Urinary tract infection frequency; CRC trans rs6075982 0.749 rs6082952 chr20:22947253 C/T cg03184243 chr8:28347962 FBXO16 0.48 6.08 0.32 3.27e-9 Obesity-related traits; CRC cis rs1552244 0.572 rs58862481 chr3:10164308 G/A cg10729496 chr3:10149963 C3orf24 0.51 5.9 0.31 8.81e-9 Alzheimer's disease; CRC cis rs6502050 0.805 rs62080003 chr17:80078957 C/T cg22110888 chr17:80059540 CCDC57 -0.41 -6.44 -0.33 4.12e-10 Life satisfaction; CRC trans rs3749237 1.000 rs4768 chr3:49758764 A/G cg21665057 chr3:196295764 WDR53;FBXO45 0.56 7.92 0.4 3.63e-14 Resting heart rate; CRC cis rs9611565 0.659 rs1810461 chr22:41927820 G/A cg06634786 chr22:41940651 POLR3H -0.68 -7.99 -0.4 2.33e-14 Vitiligo; CRC cis rs2637266 0.600 rs11001822 chr10:78325833 T/C cg18941641 chr10:78392320 NA -0.35 -5.85 -0.31 1.21e-8 Pulmonary function; CRC cis rs9534288 0.619 rs6561290 chr13:46682460 A/G cg15192986 chr13:46630673 CPB2 -0.59 -7.83 -0.4 6.95e-14 Blood protein levels; CRC cis rs2019137 0.539 rs11123170 chr2:113978940 C/G cg09704166 chr2:114031854 PAX8;LOC440839 -0.37 -6.66 -0.34 1.15e-10 Lymphocyte counts; CRC cis rs853679 0.760 rs9368563 chr6:28208558 A/G cg25164649 chr6:28176230 NA 0.55 5.75 0.3 2e-8 Depression; CRC trans rs1005277 0.579 rs2023351 chr10:38378814 A/G cg17830980 chr10:43048298 ZNF37B -0.58 -9.69 -0.47 1.08e-19 Extrinsic epigenetic age acceleration; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg03249710 chr13:48611439 NUDT15 0.42 6.36 0.33 6.71e-10 Intelligence (multi-trait analysis); CRC cis rs7666738 0.962 rs1527515 chr4:99025733 C/A cg05340658 chr4:99064831 C4orf37 0.51 7.2 0.37 4.04e-12 Colonoscopy-negative controls vs population controls; CRC cis rs57502260 0.573 rs11228295 chr11:68388588 C/G cg16797656 chr11:68205561 LRP5 0.46 6.46 0.34 3.87e-10 Total body bone mineral density (age 45-60); CRC cis rs898097 0.510 rs10445242 chr17:80891666 G/T cg19046167 chr17:80928561 B3GNTL1 0.44 7.47 0.38 7.18e-13 Breast cancer; CRC cis rs9807989 0.839 rs11695627 chr2:102970105 A/G cg03938978 chr2:103052716 IL18RAP 0.37 5.97 0.31 6.2e-9 Asthma; CRC cis rs6694672 0.681 rs476390 chr1:197253267 T/C cg13682187 chr1:196946512 CFHR5 0.5 7.05 0.36 1.05e-11 Asthma; CRC cis rs7552404 0.731 rs12078299 chr1:76365764 T/A cg10523679 chr1:76189770 ACADM 0.74 8.78 0.44 9.19e-17 Blood metabolite levels;Acylcarnitine levels; CRC cis rs1862618 0.802 rs4389648 chr5:56103602 A/G cg12311346 chr5:56204834 C5orf35 -0.8 -10.38 -0.5 4.95e-22 Initial pursuit acceleration; CRC cis rs519973 1.000 rs763342 chr3:187639375 G/T cg10168494 chr3:187635183 NA -0.5 -8.7 -0.43 1.66e-16 Allergic disease (asthma, hay fever or eczema); CRC cis rs992157 0.767 rs2382822 chr2:219173327 T/C cg00012203 chr2:219082015 ARPC2 -0.48 -7.07 -0.36 9.32e-12 Colorectal cancer; CRC trans rs6940638 0.956 rs36048693 chr6:27032711 T/G cg06606381 chr12:133084897 FBRSL1 -0.6 -6.6 -0.34 1.6e-10 Intelligence (multi-trait analysis); CRC cis rs2949837 0.581 rs924140 chr7:45963114 C/T cg15898840 chr7:45960834 IGFBP3 0.44 7.19 0.37 4.47e-12 Sitting height ratio; CRC cis rs148734725 1 rs148734725 chr3:49406708 G/A cg07274523 chr3:49395745 GPX1 0.45 6.05 0.32 4.03e-9 Educational attainment (college completion); CRC cis rs7666738 0.606 rs10006454 chr4:99080361 G/A cg05340658 chr4:99064831 C4orf37 0.49 7.21 0.37 3.95e-12 Colonoscopy-negative controls vs population controls; CRC cis rs1153858 0.943 rs12439575 chr15:45684816 T/G cg14582100 chr15:45693742 SPATA5L1 0.29 5.87 0.31 1.07e-8 Homoarginine levels; CRC cis rs7258465 1.000 rs10411009 chr19:18606266 A/G cg06462663 chr19:18546047 ISYNA1 0.47 7.16 0.37 5.3e-12 Breast cancer; CRC cis rs921968 0.565 rs7573999 chr2:219601392 A/G cg02176678 chr2:219576539 TTLL4 -0.39 -6.25 -0.33 1.31e-9 Mean corpuscular hemoglobin concentration; CRC cis rs6701037 0.681 rs6664840 chr1:175128726 A/G cg14847009 chr1:175162515 KIAA0040 -0.27 -5.85 -0.31 1.2e-8 Alcohol dependence; CRC cis rs7666738 0.830 rs13144564 chr4:98939276 A/G cg05340658 chr4:99064831 C4orf37 0.6 9.35 0.46 1.41e-18 Colonoscopy-negative controls vs population controls; CRC cis rs9549328 0.614 rs35872678 chr13:113617231 A/T cg24588162 chr13:113633484 MCF2L 0.36 6.49 0.34 3.22e-10 Systolic blood pressure; CRC trans rs853679 0.882 rs4713140 chr6:28097193 C/T cg06606381 chr12:133084897 FBRSL1 -0.9 -7.56 -0.38 4.17e-13 Depression; CRC cis rs796364 0.951 rs2881593 chr2:201000347 A/G cg23649088 chr2:200775458 C2orf69 -0.53 -6.05 -0.32 3.84e-9 Schizophrenia; CRC cis rs11723261 0.582 rs6830247 chr4:150683 G/A cg12746427 chr4:53362 ZNF718;ZNF595 0.51 7.09 0.36 8.04e-12 Immune response to smallpox vaccine (IL-6); CRC cis rs4936891 0.577 rs11219422 chr11:123920178 C/T cg22125253 chr11:123886957 OR10G4 -0.34 -6.13 -0.32 2.46e-9 Male fertility; CRC cis rs9322193 0.923 rs9689084 chr6:149960784 G/A cg13206674 chr6:150067644 NUP43 0.61 9.07 0.45 1.07e-17 Lung cancer; CRC cis rs2412208 0.509 rs7546792 chr1:7124346 C/T cg20434152 chr1:7120926 CAMTA1 -0.39 -6.91 -0.36 2.46e-11 Survival in sporadic amyotrophic lateral sclerosis; CRC cis rs10221833 0.530 rs355888 chr2:165634551 A/G cg03182029 chr2:165697222 COBLL1 0.52 6.09 0.32 3.22e-9 Response to statin therapy; CRC cis rs600806 0.815 rs10858097 chr1:109967324 C/A cg23032129 chr1:109941072 SORT1 -0.28 -5.81 -0.31 1.47e-8 Intelligence (multi-trait analysis); CRC cis rs7523050 0.643 rs35438081 chr1:109402831 G/T cg08274380 chr1:109419600 GPSM2 0.85 6.65 0.34 1.24e-10 Fat distribution (HIV); CRC cis rs12024301 0.557 rs10911415 chr1:183664889 C/T cg11505048 chr1:183622726 RGL1;APOBEC4 0.71 6.24 0.33 1.33e-9 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs561341 0.709 rs8068049 chr17:30183857 T/C cg00745463 chr17:30367425 LRRC37B 0.7 7.21 0.37 3.77e-12 Hip circumference adjusted for BMI; CRC cis rs9914988 0.576 rs11080075 chr17:27322441 A/C cg16670446 chr17:27188758 MIR451;MIR144 -0.45 -6.22 -0.32 1.51e-9 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs6546550 0.658 rs10186725 chr2:70015491 A/G cg02498382 chr2:70120550 SNRNP27 -0.41 -6.69 -0.35 9.62e-11 Prevalent atrial fibrillation; CRC cis rs9916302 0.904 rs9905432 chr17:37555918 C/A cg15445000 chr17:37608096 MED1 -0.43 -9.48 -0.46 5.3e-19 Glomerular filtration rate (creatinine); CRC cis rs34779708 0.742 rs35912711 chr10:35312996 T/C cg03585969 chr10:35415529 CREM 0.65 8.78 0.44 9.01e-17 Inflammatory bowel disease;Crohn's disease; CRC cis rs9733 0.596 rs2275236 chr1:150669952 A/G cg17724175 chr1:150552817 MCL1 -0.59 -9.43 -0.46 7.91e-19 Tonsillectomy; CRC cis rs1129187 0.755 rs3818554 chr6:42934620 C/T cg02353165 chr6:42928485 GNMT 0.68 11.28 0.53 3.69e-25 Alzheimer's disease in APOE e4+ carriers; CRC cis rs67311347 1.000 rs11716675 chr3:40485280 G/T cg24209194 chr3:40518798 ZNF619 0.42 6.33 0.33 8.25e-10 Renal cell carcinoma; CRC cis rs755249 0.567 rs16825939 chr1:39662508 G/A cg18385671 chr1:39797026 MACF1 -0.41 -5.93 -0.31 7.46e-9 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs7552404 0.731 rs10873808 chr1:76406767 T/C cg03433033 chr1:76189801 ACADM 0.65 7.78 0.39 9.55e-14 Blood metabolite levels;Acylcarnitine levels; CRC cis rs7215564 0.908 rs35844609 chr17:78664850 T/C cg09596252 chr17:78655493 RPTOR 0.56 6.11 0.32 2.76e-9 Myopia (pathological); CRC cis rs6570726 1.000 rs444564 chr6:145859795 G/C cg05347473 chr6:146136440 FBXO30 0.39 6.13 0.32 2.55e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs9549367 0.789 rs2316442 chr13:113877487 C/T cg00898013 chr13:113819073 PROZ -0.46 -6.77 -0.35 5.89e-11 Platelet distribution width; CRC cis rs10461617 0.592 rs6450403 chr5:56062737 A/C cg18230493 chr5:56204884 C5orf35 -0.43 -5.66 -0.3 3.31e-8 Type 2 diabetes; CRC cis rs7474896 0.537 rs598857 chr10:38302926 A/G cg25427524 chr10:38739819 LOC399744 0.6 7.34 0.37 1.73e-12 Obesity (extreme); CRC cis rs17253792 0.915 rs74580958 chr14:56181511 G/A cg01858014 chr14:56050164 KTN1 -0.74 -5.6 -0.3 4.43e-8 Putamen volume; CRC cis rs67311347 1.000 rs951560 chr3:40463471 A/G cg09455208 chr3:40491958 NA 0.45 9.19 0.45 4.67e-18 Renal cell carcinoma; CRC cis rs6964587 1.000 rs10488510 chr7:91660225 G/T cg17063962 chr7:91808500 NA 0.83 15.2 0.64 6.7e-40 Breast cancer; CRC cis rs7843479 0.930 rs2054713 chr8:21840534 A/G cg17168535 chr8:21777572 XPO7 0.56 9.03 0.45 1.43e-17 Mean corpuscular volume; CRC cis rs2404602 0.647 rs3812908 chr15:77176158 C/T cg23625390 chr15:77176239 SCAPER 0.85 14.08 0.61 1.42e-35 Blood metabolite levels; CRC cis rs832540 0.519 rs1445998 chr5:56268205 A/G cg24531977 chr5:56204891 C5orf35 -0.53 -8.42 -0.42 1.16e-15 Coronary artery disease; CRC cis rs4713118 0.869 rs9348775 chr6:27695329 C/T cg26587870 chr6:27730563 NA -0.45 -7.08 -0.36 8.96e-12 Parkinson's disease; CRC cis rs6762 0.550 rs8672 chr11:838634 C/G cg07691484 chr11:842764 TSPAN4;POLR2L -0.55 -7.98 -0.4 2.46e-14 Mean platelet volume; CRC cis rs2625529 0.556 rs1552134 chr15:72232898 T/A cg16672083 chr15:72433130 SENP8 0.47 6.96 0.36 1.9e-11 Red blood cell count; CRC cis rs3091242 0.933 rs926438 chr1:25753638 C/T cg20684491 chr1:25596433 NA 0.42 7.37 0.38 1.37e-12 Erythrocyte sedimentation rate; CRC cis rs1215050 0.740 rs783963 chr4:98989070 A/G cg05340658 chr4:99064831 C4orf37 0.49 7.71 0.39 1.48e-13 Waist-to-hip ratio adjusted for body mass index; CRC cis rs875971 0.862 rs17747530 chr7:65994729 G/C cg11764359 chr7:65958608 NA 0.59 8.81 0.44 7.57e-17 Aortic root size; CRC cis rs3736485 0.578 rs1456300 chr15:51982016 T/C cg08986416 chr15:51914746 DMXL2 -0.4 -5.86 -0.31 1.14e-8 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg21554109 chr19:18747733 KLHL26 0.56 9.05 0.45 1.31e-17 Liver disease severity in Alagille syndrome; CRC cis rs17666538 0.535 rs1669658 chr8:607380 A/G cg23958373 chr8:599963 NA 0.8 7.35 0.38 1.58e-12 IgG glycosylation; CRC cis rs34779708 0.733 rs7914560 chr10:35548099 G/A cg03585969 chr10:35415529 CREM 0.52 6.79 0.35 5.37e-11 Inflammatory bowel disease;Crohn's disease; CRC cis rs4665809 0.525 rs4665324 chr2:26447147 A/C cg22920501 chr2:26401640 FAM59B -0.85 -12.21 -0.56 1.54e-28 Gut microbiome composition (summer); CRC cis rs896854 0.654 rs4735339 chr8:95974373 C/T cg09323728 chr8:95962352 TP53INP1 -0.45 -7.47 -0.38 7.43e-13 Type 2 diabetes; CRC trans rs804280 0.509 rs13268030 chr8:11783073 C/T cg08975724 chr8:8085496 FLJ10661 0.39 6.09 0.32 3.11e-9 Myopia (pathological); CRC cis rs4073582 0.894 rs801733 chr11:65934549 A/C cg14036092 chr11:66035641 RAB1B 0.56 7.89 0.4 4.54e-14 Gout; CRC cis rs789859 0.965 rs812583 chr3:194406505 C/G cg02072170 chr3:194406190 FAM43A 0.42 7.23 0.37 3.44e-12 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; CRC cis rs1862618 0.853 rs10051747 chr5:56083289 C/A cg12311346 chr5:56204834 C5orf35 -0.79 -10.19 -0.49 2.21e-21 Initial pursuit acceleration; CRC cis rs11098499 1.000 rs11726229 chr4:120211580 C/T cg09307838 chr4:120376055 NA 0.65 9.96 0.48 1.39e-20 Corneal astigmatism; CRC trans rs61931739 0.517 rs7486246 chr12:34526419 T/G cg26384229 chr12:38710491 ALG10B 0.59 8.77 0.44 9.48e-17 Morning vs. evening chronotype; CRC cis rs6499255 1.000 rs55992518 chr16:69821407 C/T cg00738113 chr16:70207722 CLEC18C -0.43 -6.16 -0.32 2.11e-9 IgE levels; CRC trans rs5756813 0.688 rs12484064 chr22:38126746 C/A cg19894588 chr14:64061835 NA -0.58 -7.69 -0.39 1.71e-13 Optic cup area;Vertical cup-disc ratio; CRC cis rs2279817 1.000 rs10888048 chr1:18019742 C/T cg21791023 chr1:18019539 ARHGEF10L 0.51 6.47 0.34 3.5e-10 Neuroticism; CRC trans rs2727020 0.701 rs7949044 chr11:49597334 C/T cg15704280 chr7:45808275 SEPT13 -0.84 -12.23 -0.56 1.3e-28 Coronary artery disease; CRC cis rs6908034 0.607 rs73376681 chr6:19808175 A/G cg02682789 chr6:19804855 NA 0.78 6.83 0.35 4.16e-11 Endometriosis;Deep ovarian and/or rectovaginal disease with dense adhesions; CRC cis rs250677 0.652 rs250670 chr5:148446646 G/T cg23229984 chr5:148520753 ABLIM3 0.51 7.04 0.36 1.13e-11 Breast cancer; CRC cis rs76878669 0.561 rs10750784 chr11:66110666 A/G cg18002602 chr11:66138449 SLC29A2 -0.33 -6.91 -0.36 2.47e-11 Educational attainment (years of education); CRC cis rs1218582 0.745 rs1580943 chr1:154865125 G/A cg03351412 chr1:154909251 PMVK 0.54 8.68 0.43 1.82e-16 Prostate cancer; CRC cis rs1800469 1.000 rs2241712 chr19:41869756 C/T cg09537434 chr19:41945824 ATP5SL -0.53 -6.61 -0.34 1.57e-10 Colorectal cancer; CRC cis rs10197940 0.571 rs13393021 chr2:152413258 A/C cg06191203 chr2:152266755 RIF1 -0.56 -8.23 -0.41 4.5e-15 Lung cancer; CRC cis rs4409675 0.576 rs10751724 chr1:28215631 C/T cg23691781 chr1:28212827 C1orf38 0.34 7.88 0.4 4.8e-14 Corneal astigmatism; CRC cis rs7615952 0.599 rs60847438 chr3:125746005 T/C cg15145296 chr3:125709740 NA -0.57 -6.5 -0.34 2.98e-10 Blood pressure (smoking interaction); CRC cis rs13202913 0.709 rs11965449 chr6:151830598 C/T cg10883421 chr6:151773342 RMND1;C6orf211 -0.53 -6.37 -0.33 6.37e-10 Epstein-Barr virus copy number in lymphoblastoid cell lines; CRC cis rs7772486 0.727 rs2235481 chr6:146056848 T/C cg23711669 chr6:146136114 FBXO30 -0.62 -9.09 -0.45 9.63e-18 Lobe attachment (rater-scored or self-reported); CRC cis rs2227564 0.620 rs11000765 chr10:75512452 G/C cg00564723 chr10:75632066 CAMK2G -0.32 -7.63 -0.39 2.5e-13 Crohn's disease;Inflammatory bowel disease; CRC cis rs1129187 0.755 rs28868299 chr6:42921221 T/G cg09436375 chr6:42928200 GNMT -0.34 -6.24 -0.33 1.36e-9 Alzheimer's disease in APOE e4+ carriers; CRC cis rs1555322 0.530 rs2425042 chr20:33865895 G/A cg13662093 chr20:33865505 NA 0.51 6.58 0.34 1.88e-10 Attention deficit hyperactivity disorder; CRC cis rs6570726 0.875 rs416243 chr6:145868081 A/T cg23711669 chr6:146136114 FBXO30 0.71 12.57 0.57 7.49e-30 Lobe attachment (rater-scored or self-reported); CRC cis rs8017423 0.647 rs1958345 chr14:90823770 T/C cg14092571 chr14:90743983 NA 0.38 5.92 0.31 8.07e-9 Mortality in heart failure; CRC cis rs561341 1.000 rs508192 chr17:30315147 C/T cg00745463 chr17:30367425 LRRC37B 0.86 9.21 0.45 3.99e-18 Hip circumference adjusted for BMI; CRC cis rs2204008 0.580 rs1315373 chr12:38179114 T/G cg13010199 chr12:38710504 ALG10B -0.44 -6.34 -0.33 7.68e-10 Bladder cancer; CRC cis rs863345 0.604 rs7533071 chr1:158504479 T/A cg12129480 chr1:158549410 OR10X1 -0.3 -6.27 -0.33 1.12e-9 Pneumococcal bacteremia; CRC cis rs780096 0.546 rs12473776 chr2:27636474 A/G cg17158414 chr2:27665306 KRTCAP3 -0.29 -6.25 -0.33 1.28e-9 Total body bone mineral density; CRC trans rs1814175 0.935 rs7925863 chr11:49615802 C/A cg11707556 chr5:10655725 ANKRD33B -0.44 -8.05 -0.41 1.53e-14 Height; CRC cis rs10861342 1.000 rs11112374 chr12:105510285 G/T cg23923672 chr12:105501055 KIAA1033 0.63 5.99 0.31 5.37e-9 IgG glycosylation; CRC cis rs875971 0.825 rs1000464 chr7:65777909 G/C cg12463550 chr7:65579703 CRCP -0.53 -7.48 -0.38 6.71e-13 Aortic root size; CRC cis rs881375 1.000 rs4323544 chr9:123647377 C/T cg09586646 chr9:123605570 PSMD5;LOC253039 0.52 7.13 0.37 6.37e-12 Rheumatoid arthritis; CRC cis rs2115630 0.645 rs4842978 chr15:85197253 T/C cg17507749 chr15:85114479 UBE2QP1 -0.41 -6.12 -0.32 2.72e-9 P wave terminal force; CRC cis rs7493 0.901 rs11764079 chr7:95026229 A/G cg19678392 chr7:94953810 PON1 0.49 7.16 0.37 5.36e-12 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs7731657 0.537 rs10053245 chr5:130353033 G/A cg08523029 chr5:130500466 HINT1 -0.45 -5.8 -0.3 1.57e-8 Fasting plasma glucose; CRC cis rs12900413 1.000 rs12900413 chr15:90321039 C/T cg24249390 chr15:90295951 MESP1 0.62 9.41 0.46 8.57e-19 Coronary artery aneurysm in Kawasaki disease; CRC cis rs780096 0.506 rs1647286 chr2:27714517 A/T cg12648201 chr2:27665141 KRTCAP3 -0.33 -6.66 -0.34 1.15e-10 Total body bone mineral density; CRC trans rs7267979 0.844 rs35735333 chr20:25337205 T/G cg17903999 chr18:56338584 MALT1 0.43 6.84 0.35 3.85e-11 Liver enzyme levels (alkaline phosphatase); CRC cis rs17376456 0.825 rs10038831 chr5:93124115 C/T cg21475434 chr5:93447410 FAM172A 0.71 6.8 0.35 4.84e-11 Diabetic retinopathy; CRC cis rs449789 0.779 rs553197 chr6:159714625 G/T cg14500486 chr6:159655392 FNDC1 -0.48 -7.29 -0.37 2.38e-12 Pulse pressure; CRC cis rs11122272 0.667 rs2244992 chr1:231537220 T/C cg06096015 chr1:231504339 EGLN1 0.41 6.11 0.32 2.88e-9 Hemoglobin concentration; CRC cis rs12477438 0.798 rs13412764 chr2:99583733 G/A cg26064155 chr2:99771622 LIPT1;TSGA10 -0.75 -10.56 -0.5 1.23e-22 Chronic sinus infection; CRC cis rs7666738 0.753 rs11097594 chr4:98944486 A/G cg17366294 chr4:99064904 C4orf37 0.43 7.34 0.38 1.69e-12 Colonoscopy-negative controls vs population controls; CRC cis rs1799949 1.000 rs34572725 chr17:41428666 G/A cg25072359 chr17:41440525 NA 0.42 6.33 0.33 7.89e-10 Menopause (age at onset); CRC cis rs10751667 0.857 rs6597961 chr11:976677 T/C cg01483505 chr11:975446 AP2A2 0.41 6.15 0.32 2.27e-9 Alzheimer's disease (late onset); CRC cis rs77861329 0.748 rs4687810 chr3:52169095 T/C cg08692210 chr3:52188851 WDR51A 0.51 5.72 0.3 2.36e-8 Macrophage inflammatory protein 1b levels; CRC cis rs10512697 0.803 rs36036519 chr5:3579493 G/A cg19473799 chr5:3511975 NA -0.72 -5.67 -0.3 3.1e-8 Immune response to smallpox vaccine (IL-6); CRC cis rs4737010 0.644 rs777870 chr8:41610234 G/A cg17182837 chr8:41585554 ANK1 0.52 7.49 0.38 6.35e-13 Lymphocyte counts;High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Reticulocyte count;Reticulocyte fraction of red cells;Mean corpuscular volume;Immature fraction of reticulocytes;Mean corpuscular hemoglobin concentration; CRC cis rs6840360 1.000 rs6845944 chr4:152604520 C/T cg09659197 chr4:152720779 NA 0.5 10.59 0.5 9.76e-23 Intelligence (multi-trait analysis); CRC cis rs877282 0.853 rs10904544 chr10:756966 A/G cg17470449 chr10:769945 NA 0.61 7.95 0.4 2.99e-14 Uric acid levels; CRC cis rs853679 0.517 rs9380061 chr6:28132803 T/C cg15786705 chr6:28176104 NA 0.78 9.83 0.48 3.57e-20 Depression; CRC cis rs2730245 0.527 rs2527202 chr7:158738849 T/C cg24397884 chr7:158709396 WDR60 -0.99 -11.02 -0.52 2.92e-24 Height; CRC cis rs992157 0.700 rs10165153 chr2:219159629 T/C cg04731861 chr2:219085781 ARPC2 -0.3 -6.22 -0.32 1.47e-9 Colorectal cancer; CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg25833238 chr6:153304325 FBXO5 0.39 6.37 0.33 6.21e-10 Obesity-related traits; CRC cis rs4074493 1.000 rs4074494 chr1:231172249 G/A cg22172038 chr1:231176991 FAM89A 0.35 6.03 0.32 4.29e-9 Carotid plaque burden (smoking interaction); CRC cis rs9916302 0.706 rs2879259 chr17:37410892 C/G cg00129232 chr17:37814104 STARD3 -0.55 -6.97 -0.36 1.73e-11 Glomerular filtration rate (creatinine); CRC cis rs1008375 0.966 rs1860599 chr4:17638900 T/C cg02297831 chr4:17616191 MED28 0.43 5.71 0.3 2.58e-8 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs11229555 1.000 rs1938598 chr11:58413910 T/C cg15696309 chr11:58395628 NA -0.96 -13.7 -0.6 4.13e-34 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; CRC cis rs6547741 0.935 rs12714204 chr2:27787540 T/C cg27432699 chr2:27873401 GPN1 0.8 14.76 0.63 3.44e-38 Oral cavity cancer; CRC cis rs1862618 0.756 rs832548 chr5:56183637 G/C cg18230493 chr5:56204884 C5orf35 -0.75 -9.27 -0.45 2.61e-18 Initial pursuit acceleration; CRC cis rs7833986 0.501 rs72653978 chr8:57018393 G/A cg23139584 chr8:56987506 RPS20;SNORD54 0.91 12.38 0.56 3.79e-29 Height; CRC cis rs1005277 0.565 rs2474565 chr10:38380828 A/G cg00409905 chr10:38381863 ZNF37A -0.68 -11.33 -0.53 2.36e-25 Extrinsic epigenetic age acceleration; CRC cis rs2836974 0.931 rs2836968 chr21:40642386 A/G cg17971929 chr21:40555470 PSMG1 0.83 11.88 0.55 2.57e-27 Cognitive function; CRC cis rs9322193 0.923 rs62441279 chr6:150042330 G/A cg13206674 chr6:150067644 NUP43 0.65 9.69 0.47 1.03e-19 Lung cancer; CRC cis rs9814567 1.000 rs7356093 chr3:134238753 T/C cg06109529 chr3:134205091 CEP63;ANAPC13 -0.81 -12.36 -0.56 4.47e-29 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC trans rs6076960 0.684 rs6054049 chr20:6254909 A/G cg21095983 chr6:86352623 SYNCRIP -0.49 -6.99 -0.36 1.53e-11 Smooth-surface caries; CRC cis rs2933343 0.729 rs1680785 chr3:128644816 C/T cg11901034 chr3:128598214 ACAD9 -0.56 -8.15 -0.41 7.47e-15 IgG glycosylation; CRC cis rs1008375 1.000 rs2159583 chr4:17658838 T/C cg16339924 chr4:17578868 LAP3 0.59 8.05 0.41 1.57e-14 Parasitemia in Tripanosoma cruzi seropositivity; CRC trans rs3774749 0.565 rs1005678 chr3:50210289 C/G cg21665057 chr3:196295764 WDR53;FBXO45 0.41 6.01 0.31 4.95e-9 Intelligence (multi-trait analysis); CRC trans rs17685 0.702 rs6960598 chr7:75772991 T/C cg19862616 chr7:65841803 NCRNA00174 0.95 17.19 0.69 9.99e-48 Coffee consumption;Coffee consumption (cups per day); CRC cis rs12477438 0.520 rs6741772 chr2:99738961 A/G cg26064155 chr2:99771622 LIPT1;TSGA10 0.89 16.23 0.67 6.36e-44 Chronic sinus infection; CRC cis rs2455601 0.608 rs10840137 chr11:8890079 G/A cg09997546 chr11:8931473 C11orf17;ST5 -0.41 -6.08 -0.32 3.36e-9 Schizophrenia; CRC cis rs4481887 0.893 rs1934543 chr1:248505602 C/G cg13385794 chr1:248469461 NA 0.34 6.32 0.33 8.74e-10 Common traits (Other); CRC cis rs2836974 0.897 rs34394827 chr21:40528087 T/C cg11890956 chr21:40555474 PSMG1 1.07 19.02 0.72 6.4e-55 Cognitive function; CRC trans rs66573146 0.572 rs55740475 chr4:6954092 C/G cg07817883 chr1:32538562 TMEM39B 1.12 11.88 0.55 2.49e-27 Granulocyte percentage of myeloid white cells; CRC cis rs7845219 0.525 rs7820818 chr8:95919231 G/A cg16049864 chr8:95962084 TP53INP1 -0.45 -6.75 -0.35 6.69e-11 Type 2 diabetes; CRC cis rs7208487 0.684 rs12449852 chr17:37632088 A/G cg00129232 chr17:37814104 STARD3 -0.56 -6.8 -0.35 5.03e-11 Primary biliary cholangitis;Glomerular filtration rate in non diabetics (creatinine); CRC cis rs3820068 0.581 rs72645871 chr1:15926142 G/A cg27534772 chr1:16042836 PLEKHM2 0.54 10.49 0.5 2.13e-22 Systolic blood pressure; CRC cis rs3741404 0.560 rs12362602 chr11:63908660 G/A cg05555928 chr11:63887634 MACROD1 0.38 6.23 0.32 1.43e-9 Platelet count; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg07865790 chr12:99038290 IKBIP;APAF1 0.43 6.08 0.32 3.28e-9 Intelligence (multi-trait analysis); CRC cis rs270601 0.739 rs3900945 chr5:131592870 T/C cg27615366 chr5:131592974 PDLIM4 0.35 6.79 0.35 5.34e-11 Acylcarnitine levels; CRC cis rs1707322 0.721 rs11211157 chr1:46132844 T/C cg06784218 chr1:46089804 CCDC17 0.66 12.35 0.56 4.77e-29 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs55882075 0.583 rs9637934 chr5:179114025 G/C cg14593053 chr5:179126677 CANX 0.52 7.6 0.39 3.04e-13 Monocyte percentage of white cells; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg24550865 chr3:190040375 CLDN1 0.4 6.27 0.33 1.12e-9 Intelligence (multi-trait analysis); CRC cis rs3093024 1.000 rs3093024 chr6:167532793 C/T cg07513332 chr6:167530253 CCR6 0.33 5.78 0.3 1.75e-8 Rheumatoid arthritis; CRC cis rs9463078 0.764 rs7754698 chr6:44782717 A/G cg25276700 chr6:44698697 NA -0.27 -6.43 -0.33 4.61e-10 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; CRC cis rs2354432 0.607 rs66486822 chr1:146802653 T/A cg25205988 chr1:146714368 CHD1L -1.14 -9.47 -0.46 5.64e-19 Mitochondrial DNA levels; CRC cis rs12580194 0.593 rs7485991 chr12:55789129 T/C cg23425280 chr12:56401806 NA 0.46 5.62 0.3 4.07e-8 Cancer; CRC cis rs422249 0.512 rs174566 chr11:61592362 A/G cg00603274 chr11:61596626 FADS2 -0.44 -6.41 -0.33 4.9e-10 Trans fatty acid levels; CRC cis rs67478160 0.619 rs1187416 chr14:104311465 A/G cg08213375 chr14:104286397 PPP1R13B 0.63 13.15 0.59 4.91e-32 Schizophrenia; CRC cis rs7927771 0.832 rs10769258 chr11:47391039 C/T cg05585544 chr11:47624801 NA 0.48 8.57 0.43 4e-16 Subjective well-being; CRC cis rs1552244 0.554 rs34883592 chr3:10046165 C/T cg13047869 chr3:10149882 C3orf24 0.38 5.93 0.31 7.73e-9 Alzheimer's disease; CRC cis rs9487051 0.768 rs351742 chr6:109527325 C/T cg21918786 chr6:109611834 NA 0.35 6.12 0.32 2.68e-9 Reticulocyte fraction of red cells; CRC cis rs1448094 0.556 rs11610789 chr12:86169541 A/G cg25456477 chr12:86230367 RASSF9 0.42 7.03 0.36 1.22e-11 Major depressive disorder; CRC cis rs9322193 0.923 rs9371199 chr6:150138662 A/T cg05861140 chr6:150128134 PCMT1 -0.4 -6.05 -0.32 4.01e-9 Lung cancer; CRC trans rs1814175 0.617 rs6486020 chr11:49769149 T/G cg03929089 chr4:120376271 NA -0.92 -16.19 -0.67 9.24e-44 Height; CRC cis rs597583 0.951 rs636530 chr11:117421858 C/T cg27161313 chr11:117392002 DSCAML1 0.39 5.67 0.3 3.05e-8 Putamen volume; CRC trans rs10504229 0.953 rs114853497 chr8:58176176 A/T cg04077850 chr5:125800366 GRAMD3 0.37 6.27 0.33 1.15e-9 Developmental language disorder (linguistic errors); CRC cis rs6840360 0.557 rs1143036 chr4:152329404 A/G cg09659197 chr4:152720779 NA 0.34 6.58 0.34 1.87e-10 Intelligence (multi-trait analysis); CRC cis rs12431939 1.000 rs12432466 chr14:51638873 T/C cg23942311 chr14:51606299 NA -0.54 -5.98 -0.31 5.95e-9 Cancer; CRC cis rs7824557 0.524 rs7835318 chr8:10953874 G/A cg27411982 chr8:10470053 RP1L1 -0.42 -6.75 -0.35 6.64e-11 Retinal vascular caliber; CRC cis rs823143 0.570 rs823082 chr1:205786935 C/T cg11965913 chr1:205819406 PM20D1 -0.69 -11.3 -0.53 2.96e-25 Monocyte percentage of white cells; CRC cis rs9914988 0.943 rs7215310 chr17:27088626 G/T cg20469991 chr17:27169893 C17orf63 -0.54 -6.79 -0.35 5.16e-11 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs853679 0.550 rs6901017 chr6:28152583 T/C cg06470822 chr6:28175283 NA 0.99 13.83 0.61 1.26e-34 Depression; CRC cis rs4713118 0.869 rs9295742 chr6:27702832 G/A cg12172441 chr6:28176163 NA 0.52 7.19 0.37 4.51e-12 Parkinson's disease; CRC cis rs6540559 0.546 rs59435160 chr1:210030730 C/A cg25204440 chr1:209979598 IRF6 0.48 5.76 0.3 1.9e-8 Cleft lip with or without cleft palate; CRC cis rs7429990 0.965 rs34750113 chr3:47986392 C/T cg11946769 chr3:48343235 NME6 0.5 6.34 0.33 7.68e-10 Educational attainment (years of education); CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg09015484 chr9:96929106 NA -0.56 -6.89 -0.36 2.81e-11 Diisocyanate-induced asthma; CRC cis rs4731207 0.596 rs1525618 chr7:124654706 G/A cg23710748 chr7:124431027 NA -0.39 -6.25 -0.33 1.24e-9 Cutaneous malignant melanoma; CRC trans rs877282 0.945 rs11253398 chr10:790012 T/C cg22713356 chr15:30763199 NA 1.34 16.68 0.68 1.08e-45 Uric acid levels; CRC cis rs9467711 0.659 rs3823158 chr6:26463271 T/A cg08501292 chr6:25962987 TRIM38 0.85 5.77 0.3 1.79e-8 Autism spectrum disorder or schizophrenia; CRC trans rs11039798 0.511 rs717896 chr11:48375335 G/T cg03929089 chr4:120376271 NA -0.64 -6.85 -0.35 3.56e-11 Axial length; CRC cis rs9837602 0.882 rs6807176 chr3:99760864 A/G cg07805332 chr3:99536008 MIR548G;C3orf26 -0.49 -6.58 -0.34 1.89e-10 Breast cancer; CRC cis rs2249625 0.523 rs2496501 chr6:72885364 A/G cg18830697 chr6:72922368 RIMS1 -0.39 -7.9 -0.4 4.11e-14 Acute urticaria and angioedema (non-steroidal anti-inflammatory drug-induced); CRC cis rs17376456 0.877 rs7736620 chr5:93305762 C/T cg09848695 chr5:92956644 FAM172A;MIR2277 0.64 5.92 0.31 8.24e-9 Diabetic retinopathy; CRC cis rs7727544 0.735 rs272879 chr5:131670546 C/G cg07395648 chr5:131743802 NA -0.4 -6.37 -0.33 6.4e-10 Blood metabolite levels; CRC cis rs7918232 0.830 rs7087033 chr10:27392522 A/G cg14240646 chr10:27532245 ACBD5 -0.88 -9.91 -0.48 2.02e-20 Breast cancer; CRC cis rs7107174 0.688 rs881361 chr11:78128047 C/G cg02023728 chr11:77925099 USP35 0.4 6.07 0.32 3.52e-9 Testicular germ cell tumor; CRC cis rs7044106 0.791 rs10985009 chr9:123493039 C/T cg09419670 chr9:123605666 PSMD5;LOC253039 -0.81 -13.77 -0.6 2.29e-34 Hip circumference adjusted for BMI; CRC cis rs57590327 0.503 rs6800295 chr3:81593011 A/G cg07356753 chr3:81810745 GBE1 -0.54 -7.15 -0.37 5.66e-12 Extraversion; CRC cis rs9287719 0.601 rs1861300 chr2:10763961 A/G cg00105475 chr2:10696890 NA 0.46 7.05 0.36 1.09e-11 Prostate cancer; CRC cis rs7289126 0.966 rs2267380 chr22:38631768 T/C cg25457927 chr22:38595422 NA -0.3 -5.92 -0.31 7.99e-9 Mammographic density (dense area);Percent mammographic density; CRC cis rs8105895 0.935 rs10411943 chr19:22259782 A/G cg02657401 chr19:22469223 NA -0.34 -5.65 -0.3 3.56e-8 Body mass index (change over time); CRC cis rs2067615 0.599 rs3759310 chr12:107166122 C/G cg13491945 chr12:107078410 RFX4 0.33 5.66 0.3 3.27e-8 Heart rate; CRC cis rs6952808 0.723 rs1107592 chr7:2041432 C/T cg21782813 chr7:2030301 MAD1L1 -0.48 -8.52 -0.42 6.03e-16 Bipolar disorder and schizophrenia; CRC cis rs208520 0.789 rs9351549 chr6:66871851 A/G cg07460842 chr6:66804631 NA -1.03 -14.2 -0.62 4.96e-36 Exhaled nitric oxide output; CRC cis rs597539 0.690 rs497149 chr11:68626639 A/T cg21963583 chr11:68658836 MRPL21 0.56 10.02 0.48 8.14e-21 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs34375054 0.624 rs7295689 chr12:125680922 T/G cg25124228 chr12:125621409 AACS -0.53 -6.96 -0.36 1.91e-11 Post bronchodilator FEV1/FVC ratio; CRC cis rs1801251 1.000 rs13013142 chr2:233600606 A/G cg25237894 chr2:233734115 C2orf82 0.54 8.77 0.44 9.91e-17 Coronary artery disease; CRC cis rs7618915 0.501 rs3733041 chr3:52731598 T/C cg05573699 chr3:52720067 GNL3;PBRM1 -0.48 -7.0 -0.36 1.47e-11 Bipolar disorder; CRC cis rs9372498 0.536 rs9489450 chr6:118904385 G/A cg22561889 chr6:118971681 C6orf204 0.5 6.43 0.33 4.49e-10 Diastolic blood pressure; CRC cis rs425277 0.606 rs2257684 chr1:2077872 A/G cg21194808 chr1:2205498 SKI 0.4 5.97 0.31 6.1e-9 Height; CRC cis rs11148252 0.500 rs342768 chr13:53208882 C/T cg12458913 chr13:53173898 NA 0.76 13.84 0.61 1.24e-34 Lewy body disease; CRC cis rs9648716 1.000 rs9648716 chr7:140612163 A/T cg10747023 chr7:140774559 NA 0.47 6.11 0.32 2.74e-9 Type 2 diabetes; CRC cis rs4664293 0.867 rs73967903 chr2:160574125 G/A cg08347373 chr2:160653686 CD302 -0.47 -7.45 -0.38 8.04e-13 Monocyte percentage of white cells; CRC cis rs523522 0.923 rs1048830 chr12:120882217 G/T cg27279351 chr12:120934652 DYNLL1 0.73 10.48 0.5 2.32e-22 High light scatter reticulocyte count; CRC cis rs7615952 0.599 rs12485717 chr3:125707075 C/T cg02807482 chr3:125708958 NA 0.46 5.9 0.31 9.06e-9 Blood pressure (smoking interaction); CRC cis rs2857891 1.000 rs1388527 chr11:6948441 C/T cg04053776 chr11:6947353 ZNF215 0.52 7.08 0.36 8.52e-12 Response to cytadine analogues (cytosine arabinoside); CRC cis rs35306767 0.807 rs11253513 chr10:968450 C/T cg20503657 chr10:835505 NA 0.77 9.86 0.48 2.89e-20 Eosinophil percentage of granulocytes; CRC cis rs4889855 0.556 rs4278795 chr17:78533189 A/T cg16591659 chr17:78472290 NA 0.38 5.64 0.3 3.66e-8 Fractional excretion of uric acid; CRC cis rs1348850 0.747 rs1047884 chr2:178488281 C/G cg22681709 chr2:178499509 PDE11A -0.38 -6.97 -0.36 1.75e-11 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC trans rs1656966 1.000 rs1656966 chr3:186466252 C/T cg08436942 chr4:4249992 TMEM128 0.41 6.3 0.33 9.41e-10 Myopia (pathological); CRC cis rs1395 0.778 rs11693001 chr2:27412744 C/T cg14242246 chr2:27434262 C2orf28;SLC5A6 0.4 7.33 0.37 1.74e-12 Blood metabolite levels; CRC trans rs1455244 0.700 rs7229302 chr18:11508904 G/T cg08326301 chr2:232329264 NCL 0.42 6.26 0.33 1.18e-9 Schizophrenia; CRC cis rs11971779 0.616 rs1133068 chr7:139053143 G/A cg07862535 chr7:139043722 LUC7L2 0.57 7.35 0.38 1.61e-12 Diisocyanate-induced asthma; CRC cis rs888194 0.587 rs6606711 chr12:109849297 A/G cg19025524 chr12:109796872 NA -0.49 -7.36 -0.38 1.47e-12 Neuroticism; CRC cis rs2257205 0.667 rs8077548 chr17:56690848 T/C cg25885038 chr17:56607967 SEPT4 -0.53 -5.79 -0.3 1.62e-8 Pancreatic cancer; CRC trans rs3942852 0.774 rs924715 chr11:48181060 G/A cg15704280 chr7:45808275 SEPT13 -0.75 -9.35 -0.46 1.43e-18 Acute lymphoblastic leukemia (childhood); CRC trans rs1814175 0.867 rs7926002 chr11:49616018 A/G cg15704280 chr7:45808275 SEPT13 -0.95 -17.39 -0.69 1.75e-48 Height; CRC cis rs2281845 0.507 rs1536127 chr1:201086894 C/A cg22815214 chr1:201083145 CACNA1S 0.5 6.28 0.33 1.08e-9 Permanent tooth development; CRC cis rs9322817 0.540 rs2034823 chr6:105219573 A/T cg02098413 chr6:105308735 HACE1 -0.44 -8.51 -0.42 6.33e-16 Thyroid stimulating hormone; CRC cis rs7909074 0.966 rs879074 chr10:45400053 G/A cg05187965 chr10:45406764 TMEM72 -0.37 -8.22 -0.41 4.68e-15 Mean corpuscular volume; CRC cis rs4665809 0.590 rs4665319 chr2:26424583 A/C cg04944784 chr2:26401820 FAM59B -0.71 -9.39 -0.46 1.03e-18 Gut microbiome composition (summer); CRC cis rs972578 1.000 rs2267480 chr22:43362976 T/C cg01576275 chr22:43409880 NA -0.43 -6.62 -0.34 1.45e-10 Mean platelet volume; CRC cis rs3126085 0.935 rs4595369 chr1:152248193 G/A cg09127314 chr1:152161683 NA 0.46 5.88 0.31 9.97e-9 Atopic dermatitis; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg15256944 chr17:79651359 ARL16;HGS 0.49 6.78 0.35 5.49e-11 Anxiety disorder; CRC cis rs999943 0.846 rs999942 chr6:33624902 G/C cg14003231 chr6:33640908 ITPR3 0.93 16.41 0.67 1.25e-44 Obesity (extreme); CRC cis rs4523957 0.928 rs216219 chr17:2147291 T/C cg16513277 chr17:2031491 SMG6 0.53 8.87 0.44 4.72e-17 Autism spectrum disorder or schizophrenia;Schizophrenia; CRC cis rs7572644 0.723 rs13019037 chr2:28024642 C/T cg27432699 chr2:27873401 GPN1 0.45 5.63 0.3 3.85e-8 Response to carboplatin and paclitaxel in ovarian cancer (Caspase 3/7 EC50); CRC trans rs6472827 0.645 rs2936683 chr8:75113239 G/C cg16732884 chr16:2569654 AMDHD2;ATP6V0C 0.38 5.97 0.31 6.16e-9 Uterine fibroids; CRC cis rs138857 0.515 rs9616373 chr22:50308597 G/A cg08270630 chr22:50330655 NA -0.51 -5.8 -0.3 1.56e-8 Mean platelet volume; CRC cis rs853679 0.517 rs9468297 chr6:28118874 G/T cg15786705 chr6:28176104 NA 0.78 9.83 0.48 3.57e-20 Depression; CRC cis rs2243480 1.000 rs466983 chr7:65520496 T/G cg12463550 chr7:65579703 CRCP 0.73 6.55 0.34 2.24e-10 Diabetic kidney disease; CRC cis rs7613875 0.580 rs2624819 chr3:50010571 G/T cg24308560 chr3:49941425 MST1R -0.44 -6.89 -0.36 2.83e-11 Body mass index; CRC cis rs9916302 0.861 rs8081033 chr17:37506650 A/G cg03013999 chr17:37608204 MED1 -0.47 -7.3 -0.37 2.2e-12 Glomerular filtration rate (creatinine); CRC cis rs4843747 0.519 rs12599755 chr16:88107006 A/G cg07865391 chr16:88106882 BANP 0.45 5.61 0.3 4.2e-8 Menopause (age at onset); CRC cis rs796364 1.000 rs166845 chr2:200823360 T/A cg12253985 chr2:200820533 C2orf60;C2orf47 0.59 6.48 0.34 3.3e-10 Schizophrenia; CRC cis rs2276314 0.553 rs12964535 chr18:33611691 A/C cg19628046 chr18:33552617 C18orf21 -0.38 -6.02 -0.31 4.67e-9 Endometriosis;Drug-induced torsades de pointes; CRC cis rs1577917 0.566 rs2842611 chr6:86302034 A/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.49 -6.95 -0.36 2e-11 Response to antipsychotic treatment; CRC cis rs2295359 0.892 rs4655687 chr1:67649946 C/T cg17031739 chr1:67600172 NA 0.43 6.67 0.35 1.06e-10 Psoriasis; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg03558408 chr5:134181967 C5orf24 0.4 6.85 0.35 3.6e-11 Liver disease severity in Alagille syndrome; CRC cis rs6502050 0.799 rs12940433 chr17:80120826 C/T cg13198984 chr17:80129470 CCDC57 0.47 8.35 0.42 1.88e-15 Life satisfaction; CRC cis rs10883723 0.810 rs2296585 chr10:104245549 C/T cg22532475 chr10:104410764 TRIM8 -0.35 -6.4 -0.33 5.2400000000000005e-10 Allergic disease (asthma, hay fever or eczema); CRC cis rs889312 0.500 rs832566 chr5:56151744 C/T cg24531977 chr5:56204891 C5orf35 -0.43 -6.48 -0.34 3.36e-10 Breast cancer;Breast cancer (early onset); CRC cis rs2153535 0.580 rs1335633 chr6:8448800 C/T cg07606381 chr6:8435919 SLC35B3 0.68 10.85 0.51 1.22e-23 Motion sickness; CRC trans rs16846053 0.579 rs57887363 chr2:162588720 C/T cg18122310 chr12:50236657 BCDIN3D -0.72 -6.03 -0.32 4.39e-9 Blood osmolality (transformed sodium); CRC cis rs7043114 0.507 rs10820971 chr9:95161740 G/C cg14631576 chr9:95140430 CENPP -0.3 -5.63 -0.3 3.78e-8 Height; CRC cis rs9911578 1.000 rs9907499 chr17:56949044 A/G cg12560992 chr17:57184187 TRIM37 0.92 17.0 0.68 6.03e-47 Intelligence (multi-trait analysis); CRC cis rs908922 0.676 rs1856119 chr1:152512483 A/G cg09873164 chr1:152488093 CRCT1 0.38 6.4 0.33 5.37e-10 Hair morphology; CRC cis rs12620999 0.555 rs4078064 chr2:238110296 C/T cg23555395 chr2:238036564 NA -0.44 -6.88 -0.35 3.11e-11 Systemic lupus erythematosus; CRC cis rs2760061 0.583 rs697763 chr1:228192622 G/C cg02753203 chr1:228287806 NA 0.87 12.74 0.57 1.71e-30 Diastolic blood pressure; CRC cis rs62064224 0.714 rs11653974 chr17:30635002 T/C cg18200150 chr17:30822561 MYO1D 0.47 9.56 0.47 2.81e-19 Schizophrenia; CRC trans rs1346081 0.786 rs1425645 chr4:68028175 C/T cg02546941 chr17:73030677 NA 0.51 6.17 0.32 2.02e-9 Intelligence (multi-trait analysis); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg04915463 chr1:162039957 NOS1AP 0.44 6.09 0.32 3.16e-9 Response to antipsychotic treatment; CRC cis rs12995491 0.763 rs1914735 chr2:88511953 A/T cg18490616 chr2:88469792 THNSL2 -0.39 -5.72 -0.3 2.42e-8 Response to metformin (IC50); CRC cis rs3096299 0.967 rs2911255 chr16:89487137 C/T cg01788221 chr16:89496183 ANKRD11 -0.47 -7.15 -0.37 5.54e-12 Multiple myeloma (IgH translocation); CRC cis rs2386661 0.704 rs2386650 chr10:5678058 G/A cg26603656 chr10:5671107 NA 0.56 9.21 0.45 3.89e-18 Breast cancer; CRC trans rs11031096 0.702 rs1015998 chr11:4150869 G/A cg22978087 chr8:24814126 NEFL 0.33 6.08 0.32 3.37e-9 Mean corpuscular volume;Mean corpuscular hemoglobin; CRC cis rs1153858 0.621 rs1719237 chr15:45579822 G/A cg21132104 chr15:45694354 SPATA5L1 0.53 6.94 0.36 2.09e-11 Homoarginine levels; CRC cis rs7584330 0.868 rs67071074 chr2:238395429 T/C cg14458575 chr2:238380390 NA 0.65 11.41 0.53 1.22e-25 Prostate cancer; CRC trans rs561341 0.941 rs72825736 chr17:30330286 G/A cg20587970 chr11:113659929 NA -1.42 -20.26 -0.75 8.39e-60 Hip circumference adjusted for BMI; CRC trans rs9858542 0.953 rs9853683 chr3:49512588 A/G cg21665057 chr3:196295764 WDR53;FBXO45 -0.65 -8.86 -0.44 5.12e-17 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs7666738 0.830 rs1426663 chr4:98990092 T/G cg17366294 chr4:99064904 C4orf37 0.43 7.27 0.37 2.64e-12 Colonoscopy-negative controls vs population controls; CRC trans rs11098499 0.818 rs7688802 chr4:120451668 G/A cg25214090 chr10:38739885 LOC399744 0.65 10.07 0.49 5.96e-21 Corneal astigmatism; CRC cis rs72730918 0.564 rs11070861 chr15:51894270 A/T cg14296394 chr15:51910925 DMXL2 -0.44 -5.68 -0.3 2.9e-8 Intelligence (multi-trait analysis); CRC cis rs9399135 0.660 rs9389248 chr6:135282656 T/C cg24558204 chr6:135376177 HBS1L 0.53 7.91 0.4 3.83e-14 Red blood cell count; CRC cis rs2415984 0.579 rs2817548 chr14:46969149 A/T cg14871534 chr14:47121158 RPL10L 0.4 5.98 0.31 5.66e-9 Number of children ever born; CRC trans rs6011368 0.840 rs6062361 chr20:62904542 C/T cg13869341 chr1:15865 WASH5P -0.51 -7.85 -0.4 5.84e-14 Clozapine-induced cytotoxicity; CRC cis rs6860806 0.531 rs2631359 chr5:131707892 C/T cg04518342 chr5:131593106 PDLIM4 -0.43 -7.06 -0.36 9.74e-12 Breast cancer; CRC cis rs10504229 0.593 rs1442127 chr8:57992136 T/C cg02725872 chr8:58115012 NA -0.45 -6.65 -0.34 1.22e-10 Developmental language disorder (linguistic errors); CRC cis rs9649213 0.574 rs7789440 chr7:97888798 G/T cg24562669 chr7:97807699 LMTK2 0.5 8.52 0.43 5.92e-16 Prostate cancer (SNP x SNP interaction); CRC cis rs10791323 0.604 rs2853116 chr11:133707063 A/G cg15485101 chr11:133734466 NA 0.41 6.83 0.35 4.08e-11 Childhood ear infection; CRC cis rs7769051 0.522 rs9493449 chr6:133126179 T/A cg07930552 chr6:133119739 C6orf192 0.92 7.33 0.37 1.84e-12 Type 2 diabetes nephropathy; CRC cis rs12422267 1.000 rs12422267 chr12:132601596 A/G cg09764611 chr12:132620959 NA -0.68 -5.76 -0.3 1.96e-8 Plasma amyloid beta peptide concentrations (ABx-40); CRC cis rs34779708 0.931 rs4934723 chr10:35381763 A/G cg03585969 chr10:35415529 CREM 0.67 8.87 0.44 4.78e-17 Inflammatory bowel disease;Crohn's disease; CRC cis rs947211 1.000 rs1775151 chr1:205745684 C/T cg07167872 chr1:205819463 PM20D1 0.41 5.65 0.3 3.56e-8 Parkinson's disease; CRC cis rs11098499 0.818 rs7688802 chr4:120451668 G/A cg09307838 chr4:120376055 NA 0.69 10.34 0.5 6.68e-22 Corneal astigmatism; CRC cis rs534126 0.961 rs7810486 chr7:143007111 G/A cg04039957 chr7:143013207 CLCN1 0.35 6.19 0.32 1.79e-9 Cancer; CRC cis rs12760731 0.720 rs1994233 chr1:178269823 C/T cg00404053 chr1:178313656 RASAL2 -0.99 -10.6 -0.5 9.15e-23 Obesity-related traits; CRC cis rs1005277 0.522 rs200943 chr10:38148730 A/G cg00409905 chr10:38381863 ZNF37A -0.62 -10.22 -0.49 1.78e-21 Extrinsic epigenetic age acceleration; CRC cis rs752010 0.714 rs6664708 chr1:42083070 G/A cg06885757 chr1:42089581 HIVEP3 0.47 8.44 0.42 1.02e-15 Lupus nephritis in systemic lupus erythematosus; CRC cis rs736408 0.562 rs12497998 chr3:52793602 C/T cg08222913 chr3:52553049 STAB1 -0.34 -6.24 -0.33 1.38e-9 Bipolar disorder; CRC cis rs12701220 0.689 rs12701824 chr7:1102364 G/A cg26769984 chr7:1090371 C7orf50 0.62 8.07 0.41 1.35e-14 Bronchopulmonary dysplasia; CRC cis rs6502050 0.799 rs4789680 chr17:80100547 C/A cg19223190 chr17:80058835 NA 0.4 6.36 0.33 6.88e-10 Life satisfaction; CRC cis rs35883536 1.000 rs11547648 chr1:101106268 G/T cg14515779 chr1:101123966 NA -0.43 -8.3 -0.42 2.75e-15 Monocyte count; CRC cis rs60871478 0.838 rs7789321 chr7:800977 A/G cg05535760 chr7:792225 HEATR2 0.99 12.12 0.56 3.21e-28 Cerebrospinal P-tau181p levels; CRC trans rs2860975 0.542 rs1579029 chr10:96811010 T/C cg16459667 chr5:161124759 GABRA6 -0.38 -6.01 -0.31 5.03e-9 Immune response to smallpox vaccine (IL-6); CRC cis rs896854 0.812 rs4582532 chr8:95969257 G/A cg23172400 chr8:95962367 TP53INP1 -0.48 -8.14 -0.41 8.48e-15 Type 2 diabetes; CRC cis rs9443645 0.901 rs9361451 chr6:79555055 T/C cg11833968 chr6:79620685 NA -0.36 -6.36 -0.33 6.62e-10 Intelligence (multi-trait analysis); CRC cis rs7552404 0.696 rs67487205 chr1:76373756 T/C cg03433033 chr1:76189801 ACADM 0.72 8.75 0.43 1.12e-16 Blood metabolite levels;Acylcarnitine levels; CRC cis rs172166 0.561 rs149976 chr6:27987776 C/T cg06470822 chr6:28175283 NA -0.66 -9.87 -0.48 2.69e-20 Cardiac Troponin-T levels; CRC cis rs8170 0.603 rs8109328 chr19:17417955 C/T cg14325436 chr19:17404977 ABHD8 -0.35 -5.65 -0.3 3.43e-8 Breast cancer (estrogen-receptor negative);Breast Cancer in BRCA1 mutation carriers;Ovarian cancer;Breast cancer;Epithelial ovarian cancer; CRC cis rs9322193 1.000 rs9377228 chr6:149921998 G/A cg13206674 chr6:150067644 NUP43 0.64 9.69 0.47 1.04e-19 Lung cancer; CRC cis rs262150 1.000 rs262154 chr7:158773936 G/A cg19418458 chr7:158789849 NA -0.48 -7.85 -0.4 5.83e-14 Facial morphology (factor 20); CRC cis rs9976767 0.608 rs3746923 chr21:43826344 C/T cg23042151 chr21:43824109 UBASH3A -0.43 -7.52 -0.38 5.29e-13 Type 1 diabetes; CRC cis rs7613875 0.620 rs13079006 chr3:49996924 G/T cg24110177 chr3:50126178 RBM5 -0.52 -7.81 -0.4 7.66e-14 Body mass index; CRC cis rs10256972 0.616 rs6957733 chr7:1106327 T/G cg16145915 chr7:1198662 ZFAND2A -0.34 -6.95 -0.36 2e-11 Longevity;Endometriosis; CRC cis rs1799949 0.965 rs8176130 chr17:41258043 C/T cg19454999 chr17:41278357 BRCA1;NBR2 0.56 8.9 0.44 3.88e-17 Menopause (age at onset); CRC cis rs12541635 0.934 rs60482457 chr8:106970504 A/G cg10147462 chr8:107024639 NA 0.4 6.41 0.33 5.16e-10 Age of smoking initiation; CRC cis rs34172651 0.837 rs12596793 chr16:24823667 C/G cg06505273 chr16:24850292 NA 0.4 6.03 0.32 4.49e-9 Intelligence (multi-trait analysis); CRC cis rs61160187 0.582 rs4647132 chr5:60182720 C/T cg16298547 chr5:60138761 ELOVL7 -0.28 -5.93 -0.31 7.59e-9 Educational attainment (years of education);Educational attainment (college completion); CRC cis rs561341 1.000 rs537166 chr17:30326827 C/T cg23018236 chr17:30244563 NA -0.6 -8.08 -0.41 1.21e-14 Hip circumference adjusted for BMI; CRC cis rs7666738 0.962 rs2865950 chr4:99040061 T/C cg05340658 chr4:99064831 C4orf37 0.53 7.63 0.39 2.55e-13 Colonoscopy-negative controls vs population controls; CRC cis rs13064411 0.542 rs7650671 chr3:113201216 C/T cg18753928 chr3:113234510 CCDC52 -0.49 -7.73 -0.39 1.33e-13 Response to simvastatin treatment (PCSK9 protein level change); CRC cis rs1348850 0.526 rs4243389 chr2:178379783 G/C cg27490568 chr2:178487706 NA 0.58 6.97 0.36 1.72e-11 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs9311474 0.629 rs13081028 chr3:52555316 G/A cg10802521 chr3:52805072 NEK4 -0.41 -6.3 -0.33 9.41e-10 Electroencephalogram traits; CRC cis rs2227564 0.597 rs2271271 chr10:75558867 G/A cg16540259 chr10:75572220 NDST2 0.52 7.91 0.4 3.98e-14 Crohn's disease;Inflammatory bowel disease; CRC cis rs7258465 1.000 rs10442 chr19:18545341 A/C cg10790698 chr19:18539756 SSBP4 -0.46 -8.72 -0.43 1.44e-16 Breast cancer; CRC cis rs9916302 0.904 rs8081338 chr17:37406139 C/T cg00129232 chr17:37814104 STARD3 -0.55 -8.07 -0.41 1.31e-14 Glomerular filtration rate (creatinine); CRC cis rs11212617 0.967 rs227041 chr11:108222801 G/T cg12106634 chr11:108092400 ATM;NPAT 0.44 6.62 0.34 1.47e-10 Response to metformin in type 2 diabetes (glycemic); CRC cis rs2032447 0.869 rs199752 chr6:26012875 C/T cg18357526 chr6:26021779 HIST1H4A 0.8 12.25 0.56 1.15e-28 Intelligence (multi-trait analysis); CRC cis rs9322193 0.923 rs9479810 chr6:150072495 C/T cg00933542 chr6:150070202 PCMT1 0.28 5.68 0.3 2.93e-8 Lung cancer; CRC cis rs34779708 0.966 rs4934537 chr10:35441512 C/T cg03585969 chr10:35415529 CREM 0.66 8.75 0.43 1.14e-16 Inflammatory bowel disease;Crohn's disease; CRC cis rs79839061 0.610 rs11733713 chr4:869169 A/G cg07828340 chr4:882639 GAK 1.13 11.0 0.52 3.68e-24 Intelligence (multi-trait analysis); CRC cis rs58688157 0.705 rs7928902 chr11:609068 G/A cg11503833 chr11:492997 NA 0.44 5.64 0.3 3.63e-8 Systemic lupus erythematosus; CRC cis rs3749237 0.595 rs4855864 chr3:49521974 C/T cg02487422 chr3:49467188 NICN1 0.41 6.76 0.35 6.39e-11 Resting heart rate; CRC cis rs1707322 0.821 rs10749857 chr1:46248143 C/T cg03146154 chr1:46216737 IPP 0.62 8.84 0.44 6.08e-17 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs1865760 0.713 rs1130000 chr6:25985396 A/G cg18357526 chr6:26021779 HIST1H4A 0.39 5.6 0.3 4.47e-8 Height; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg07921731 chr18:47013764 C18orf32;MIR1539 0.5 6.8 0.35 5.04e-11 Anxiety disorder; CRC cis rs67340775 0.541 rs200975 chr6:27855625 G/T cg19041857 chr6:27730383 NA -0.62 -6.8 -0.35 5.04e-11 Lung cancer in ever smokers; CRC cis rs8067545 0.611 rs12938355 chr17:20195217 A/G cg13482628 chr17:19912719 NA -0.48 -7.59 -0.39 3.31e-13 Schizophrenia; CRC cis rs9389248 0.690 rs1028314 chr6:135255710 A/C cg24558204 chr6:135376177 HBS1L -0.54 -7.95 -0.4 3.04e-14 High light scatter reticulocyte percentage of red cells; CRC cis rs10504229 0.728 rs55812114 chr8:58157453 C/T cg22535103 chr8:58192502 C8orf71 -0.7 -8.43 -0.42 1.07e-15 Developmental language disorder (linguistic errors); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg00747360 chr7:127228685 ARF5 0.41 6.35 0.33 7.29e-10 Liver disease severity in Alagille syndrome; CRC trans rs629535 0.773 rs655299 chr8:70074534 C/T cg21567404 chr3:27674614 NA 0.92 15.32 0.65 2.38e-40 Dupuytren's disease; CRC cis rs7762018 0.660 rs41265385 chr6:170068086 C/T cg24289452 chr6:170231220 NA -0.67 -6.78 -0.35 5.59e-11 Thiazide-induced adverse metabolic effects in hypertensive patients; CRC cis rs10832963 1.000 rs2084220 chr11:18656932 C/T cg09201001 chr11:18656081 SPTY2D1 0.79 12.29 0.56 7.87e-29 Breast cancer; CRC trans rs36069016 1 rs36069016 chr8:25058491 C/T cg05951425 chr10:75457629 AGAP5 0.41 6.01 0.31 4.88e-9 Coronary artery disease; CRC cis rs3806843 0.932 rs2563256 chr5:140141779 G/T cg19875535 chr5:140030758 IK -0.55 -8.8 -0.44 7.81e-17 Depressive symptoms (multi-trait analysis); CRC cis rs870825 0.860 rs11132253 chr4:185595472 C/T cg07424746 chr4:185654737 MLF1IP -0.57 -5.64 -0.3 3.76e-8 Blood protein levels; CRC cis rs875971 0.651 rs2420596 chr7:65915983 T/C cg00343986 chr7:65444356 GUSB 0.42 5.85 0.31 1.22e-8 Aortic root size; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg05451842 chr14:93581139 ITPK1 0.41 6.28 0.33 1.1e-9 Liver disease severity in Alagille syndrome; CRC cis rs8062405 0.824 rs62034326 chr16:28539293 A/G cg16576597 chr16:28551801 NUPR1 0.47 7.34 0.37 1.74e-12 Cognitive ability (multi-trait analysis);Cognitive ability; CRC cis rs10751667 0.666 rs10902248 chr11:957742 A/G ch.11.42038R chr11:967971 AP2A2 0.57 9.99 0.48 1.07e-20 Alzheimer's disease (late onset); CRC trans rs208520 0.661 rs4710566 chr6:66848538 G/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.07 -14.75 -0.63 3.82e-38 Exhaled nitric oxide output; CRC cis rs2836974 0.932 rs13048178 chr21:40561012 G/T cg11644478 chr21:40555479 PSMG1 0.81 12.3 0.56 7.53e-29 Cognitive function; CRC trans rs8123881 0.733 rs7268466 chr20:15810676 C/T cg13484946 chr2:61293354 KIAA1841 0.52 6.0 0.31 5.19e-9 Body mass index; CRC trans rs482700 0.842 rs4376166 chr4:116162730 T/A cg00976532 chr16:2636476 PDPK1 0.35 6.06 0.32 3.62e-9 Stromal-cell-derived factor 1 alpha levels; CRC cis rs2795502 1.000 rs2796575 chr10:43374911 A/G cg27426351 chr10:43362370 NA 0.63 7.54 0.38 4.62e-13 Blood protein levels; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg15186648 chr13:103452789 BIVM;KDELC1 -0.41 -6.05 -0.32 4e-9 Myopia (pathological); CRC cis rs11622475 0.677 rs7145372 chr14:104359121 A/G cg12183467 chr14:104352244 NA 0.45 6.19 0.32 1.83e-9 Bipolar disorder; CRC cis rs7618915 0.501 rs2079929 chr3:52765646 C/T cg11645453 chr3:52864694 ITIH4 0.36 6.48 0.34 3.31e-10 Bipolar disorder; CRC cis rs3823572 0.542 rs11764961 chr7:133631142 C/A cg03336402 chr7:133662267 EXOC4 0.67 10.32 0.49 8.37e-22 Intelligence (multi-trait analysis); CRC trans rs2243480 1.000 rs1039664 chr7:65449716 T/G cg10756647 chr7:56101905 PSPH 0.71 7.84 0.4 6.35e-14 Diabetic kidney disease; CRC trans rs12200782 0.578 rs2237233 chr6:26387535 A/G cg25800765 chr12:85673347 ALX1 0.26 5.96 0.31 6.54e-9 Small cell lung carcinoma; CRC cis rs9323205 0.677 rs4264315 chr14:51728356 G/A cg23942311 chr14:51606299 NA -0.52 -6.18 -0.32 1.9e-9 Cancer; CRC cis rs611744 0.647 rs6981420 chr8:109266694 T/G cg18478394 chr8:109455254 TTC35 0.39 6.06 0.32 3.81e-9 Dupuytren's disease; CRC cis rs6951245 0.748 rs79658522 chr7:1095877 A/G cg07217954 chr7:1067459 C7orf50 0.55 5.72 0.3 2.36e-8 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs6951245 1.000 rs76388414 chr7:1100694 G/A cg20603222 chr7:1096387 C7orf50;GPR146 -0.72 -8.66 -0.43 2.19e-16 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs2836950 0.520 rs2836966 chr21:40637521 A/G cg11890956 chr21:40555474 PSMG1 -0.63 -9.34 -0.46 1.46e-18 Menarche (age at onset); CRC cis rs1707322 0.752 rs8179296 chr1:46143791 G/A cg06784218 chr1:46089804 CCDC17 0.66 12.35 0.56 4.77e-29 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs875971 0.862 rs6960446 chr7:65733259 A/G cg18876405 chr7:65276391 NA -0.52 -8.34 -0.42 2.06e-15 Aortic root size; CRC trans rs12599106 0.629 rs1391904 chr16:34548934 C/T cg01171360 chr6:293285 DUSP22 -0.46 -6.49 -0.34 3.12e-10 Menopause (age at onset); CRC cis rs1045714 0.895 rs73035504 chr7:2642878 G/A cg24848437 chr7:2645542 IQCE 0.56 5.88 0.31 9.82e-9 Urate levels in lean individuals; CRC cis rs1577917 0.958 rs11755048 chr6:86514334 A/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.59 -7.09 -0.36 8.15e-12 Response to antipsychotic treatment; CRC cis rs10931896 0.531 rs295117 chr2:201146828 C/T cg23649088 chr2:200775458 C2orf69 0.45 6.3 0.33 9.4e-10 Systolic blood pressure; CRC cis rs875971 0.965 rs6971509 chr7:65714970 G/T cg18912574 chr7:65842487 NCRNA00174 -0.37 -6.38 -0.33 6.09e-10 Aortic root size; CRC trans rs6600671 1.000 rs10794671 chr1:121168242 A/C cg09829573 chr1:144692074 NBPF9 -0.4 -6.07 -0.32 3.49e-9 Hip geometry; CRC cis rs739401 0.572 rs410820 chr11:3080102 G/A cg08508325 chr11:3079039 CARS -0.51 -9.14 -0.45 6.48e-18 Longevity; CRC cis rs9560113 1.000 rs4773386 chr13:112180896 C/G cg10483660 chr13:112241077 NA 0.36 5.77 0.3 1.87e-8 Menarche (age at onset); CRC cis rs9478638 0.507 rs9371882 chr6:155638741 G/A cg06694381 chr6:155569200 TIAM2 -0.48 -6.2 -0.32 1.66e-9 Electroencephalogram traits; CRC cis rs4665809 0.941 rs11126336 chr2:26245931 C/T cg04944784 chr2:26401820 FAM59B -0.6 -7.51 -0.38 5.77e-13 Gut microbiome composition (summer); CRC cis rs5769765 0.819 rs9616379 chr22:50312035 C/T cg22709217 chr22:50311962 ALG12;CRELD2 -1.12 -18.46 -0.71 9.73e-53 Schizophrenia; CRC cis rs11622475 1.000 rs10136440 chr14:104397367 C/A cg20488157 chr14:104394430 TDRD9 -0.67 -9.79 -0.47 5.06e-20 Bipolar disorder; CRC cis rs4319547 0.774 rs7307233 chr12:123124301 C/G cg23029597 chr12:123009494 RSRC2 -0.53 -6.94 -0.36 2.15e-11 Body mass index; CRC trans rs11581859 0.950 rs55962014 chr1:99373428 T/C cg12183875 chr3:169587454 LRRC31 0.27 6.43 0.33 4.37e-10 Response to cognitive-behavioural therapy in anxiety disorder; CRC cis rs4888262 0.526 rs8055803 chr16:74615190 A/G cg01733217 chr16:74700730 RFWD3 0.78 11.92 0.55 1.85e-27 Testicular germ cell tumor; CRC cis rs4563143 0.675 rs56123392 chr19:29255631 A/C cg14983838 chr19:29218262 NA 0.46 6.76 0.35 6.47e-11 Methadone dose in opioid dependence; CRC cis rs2070488 0.965 rs1984312 chr3:38538466 G/T cg01465620 chr3:38496096 LOC100128640;ACVR2B -0.87 -15.87 -0.66 1.62e-42 Electrocardiographic conduction measures; CRC cis rs35306767 0.622 rs66462130 chr10:1022108 C/T cg20503657 chr10:835505 NA 0.94 10.71 0.51 3.53e-23 Eosinophil percentage of granulocytes; CRC cis rs72781680 0.752 rs7578606 chr2:23902360 T/C cg08917208 chr2:24149416 ATAD2B 1.02 9.16 0.45 5.8e-18 Lymphocyte counts; CRC cis rs7945705 0.719 rs2012680 chr11:8996059 G/A cg21881798 chr11:8931708 C11orf17;ST5 -0.66 -11.05 -0.52 2.44e-24 Hemoglobin concentration; CRC cis rs875971 0.830 rs587360 chr7:65522698 C/A cg18912574 chr7:65842487 NCRNA00174 0.38 6.52 0.34 2.6e-10 Aortic root size; CRC cis rs11166629 1.000 rs1545240 chr8:135642632 A/C cg27224718 chr8:135614730 ZFAT 0.5 7.44 0.38 8.72e-13 Smoking quantity; CRC cis rs4713118 0.513 rs149950 chr6:28033039 T/G cg03623178 chr6:28175578 NA 0.77 11.49 0.54 6.21e-26 Parkinson's disease; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg05485520 chr3:45883628 LZTFL1 0.44 6.23 0.32 1.41e-9 Response to antipsychotic treatment; CRC cis rs1865760 0.534 rs72834629 chr6:26023032 C/T cg17691542 chr6:26056736 HIST1H1C 0.63 8.94 0.44 2.91e-17 Height; CRC cis rs1008375 0.863 rs4698632 chr4:17614894 T/C cg16339924 chr4:17578868 LAP3 0.47 6.23 0.32 1.4e-9 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs3617 0.625 rs2240915 chr3:52859526 T/A cg18099408 chr3:52552593 STAB1 -0.35 -6.13 -0.32 2.46e-9 Red blood cell count;Autism spectrum disorder or schizophrenia; CRC cis rs3785574 0.962 rs4968660 chr17:61792221 G/A cg06873352 chr17:61820015 STRADA 0.49 7.91 0.4 3.85e-14 Height; CRC cis rs2333194 0.739 rs61987083 chr14:73915861 T/C cg19682024 chr14:74008259 HEATR4;ACOT1 -0.42 -6.23 -0.32 1.47e-9 Bipolar disorder with mood-incongruent psychosis; CRC cis rs4660261 0.526 rs2906458 chr1:44336389 A/G cg12908607 chr1:44402522 ARTN 0.54 9.77 0.47 6e-20 Intelligence (multi-trait analysis); CRC cis rs67981189 0.529 rs2158996 chr14:71529599 G/A cg15910301 chr14:71632612 NA 0.31 6.14 0.32 2.41e-9 Schizophrenia; CRC cis rs910187 0.678 rs6066229 chr20:45815341 A/G cg27589058 chr20:45804311 EYA2 0.39 7.84 0.4 6.4e-14 Migraine; CRC cis rs910316 0.967 rs8007539 chr14:75664953 T/C cg08847533 chr14:75593920 NEK9 -0.85 -15.17 -0.64 8.66e-40 Height; CRC cis rs9914988 0.673 rs12325788 chr17:27080049 G/A cg12682573 chr17:27188876 MIR451;MIR144 0.61 9.32 0.46 1.79e-18 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg22438603 chr5:127418940 SLC12A2;FLJ33630 0.41 6.57 0.34 1.99e-10 Liver disease severity in Alagille syndrome; CRC cis rs875971 0.862 rs1643375 chr7:65872677 T/C cg12463550 chr7:65579703 CRCP 0.5 6.98 0.36 1.65e-11 Aortic root size; CRC cis rs116095464 0.558 rs55833259 chr5:286728 G/A cg22857025 chr5:266934 NA -1.16 -12.06 -0.55 5.57e-28 Breast cancer; CRC cis rs7659604 1.000 rs10016433 chr4:122664771 A/G cg20573242 chr4:122745356 CCNA2 0.4 6.01 0.31 4.92e-9 Type 2 diabetes; CRC cis rs17065868 0.764 rs61949762 chr13:45005842 T/C cg10246903 chr13:45222710 NA 0.56 5.63 0.3 3.82e-8 Antineutrophil cytoplasmic antibody-associated vasculitis; CRC cis rs1971762 0.583 rs2365345 chr12:54086820 C/T cg06632207 chr12:54070931 ATP5G2 0.39 6.71 0.35 8.4e-11 Height; CRC trans rs951252 0.504 rs11734405 chr4:146081096 C/T cg04867738 chr17:42298359 UBTF 0.47 6.42 0.33 4.72e-10 Hip circumference; CRC trans rs17106184 1.000 rs12062764 chr1:51296907 G/A cg02869289 chr19:46177325 MIR642;GIPR 0.62 6.07 0.32 3.51e-9 Type 2 diabetes; CRC cis rs9814567 1.000 rs9289475 chr3:134236459 G/A cg06541857 chr3:134203789 ANAPC13;CEP63 -0.39 -5.77 -0.3 1.8e-8 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs1552244 1.000 rs56394721 chr3:10150795 A/G cg16606324 chr3:10149918 C3orf24 0.73 9.71 0.47 9.09e-20 Alzheimer's disease; CRC cis rs6502050 0.835 rs4789672 chr17:80126603 T/C cg22110888 chr17:80059540 CCDC57 0.41 6.54 0.34 2.39e-10 Life satisfaction; CRC cis rs7811142 0.666 rs28401739 chr7:99905684 A/G cg07160278 chr7:100027354 MEPCE;ZCWPW1 0.96 12.76 0.58 1.48e-30 Platelet count; CRC cis rs798554 0.797 rs1182174 chr7:2875420 G/A cg09658497 chr7:2847517 GNA12 -0.41 -5.75 -0.3 2.02e-8 Height; CRC cis rs3092073 0.624 rs11696196 chr20:44574533 C/T cg27529037 chr20:44575021 PCIF1 0.44 7.52 0.38 5.23e-13 Intelligence (multi-trait analysis); CRC cis rs2811415 0.597 rs10934845 chr3:127763859 C/T cg13719885 chr3:127795394 NA -0.36 -5.62 -0.3 4.1e-8 Lung function (FEV1/FVC); CRC cis rs7659604 0.628 rs6838153 chr4:122720999 A/G cg19748678 chr4:122722346 EXOSC9 0.68 10.8 0.51 1.85e-23 Type 2 diabetes; CRC cis rs7932354 0.583 rs3829940 chr11:46879973 A/G cg19486271 chr11:47235900 DDB2 -0.42 -6.34 -0.33 7.49e-10 Bone mineral density (hip);Bone mineral density; CRC cis rs9309711 0.922 rs13399524 chr2:3480206 C/G cg10845886 chr2:3471009 TTC15 -0.68 -10.93 -0.52 6.07e-24 Neurofibrillary tangles; CRC cis rs9309473 0.607 rs6716776 chr2:73587713 T/C cg20560298 chr2:73613845 ALMS1 -0.49 -6.46 -0.34 3.73e-10 Metabolite levels; CRC cis rs1559088 0.948 rs2019603 chr19:33577367 C/T cg27124370 chr19:33622961 WDR88 -0.46 -6.49 -0.34 3.17e-10 Bone ultrasound measurement (broadband ultrasound attenuation); CRC trans rs10982213 0.830 rs2274163 chr9:117188714 C/T cg20355731 chr12:37942439 NA 0.41 6.28 0.33 1.1e-9 Interleukin-6 levels; CRC cis rs9914988 0.832 rs34267753 chr17:27157586 T/C cg20469991 chr17:27169893 C17orf63 -0.59 -7.19 -0.37 4.48e-12 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs1862618 0.525 rs2662016 chr5:56269047 A/G cg03609598 chr5:56110824 MAP3K1 0.66 7.87 0.4 5.29e-14 Initial pursuit acceleration; CRC trans rs629535 0.821 rs660144 chr8:70035629 T/C cg21567404 chr3:27674614 NA 0.95 16.15 0.66 1.35e-43 Dupuytren's disease; CRC cis rs9911578 0.935 rs34523895 chr17:57034095 T/C cg12560992 chr17:57184187 TRIM37 0.83 14.7 0.63 6.08e-38 Intelligence (multi-trait analysis); CRC cis rs13392177 0.684 rs6720105 chr2:219080718 G/A cg04880052 chr2:219191631 PNKD -0.41 -6.17 -0.32 2.01e-9 Pyoderma gangrenosum in inflammatory bowel disease; CRC cis rs1218582 0.772 rs6656435 chr1:154876869 G/A cg06221963 chr1:154839813 KCNN3 -0.76 -15.38 -0.65 1.37e-40 Prostate cancer; CRC cis rs34172651 0.917 rs2112786 chr16:24778944 C/T cg06505273 chr16:24850292 NA 0.39 6.01 0.31 5.04e-9 Intelligence (multi-trait analysis); CRC cis rs34779708 0.966 rs12762493 chr10:35471873 G/A cg03585969 chr10:35415529 CREM 0.55 7.45 0.38 8.13e-13 Inflammatory bowel disease;Crohn's disease; CRC cis rs6141769 0.542 rs6058821 chr20:31304713 C/T cg13636640 chr20:31349939 DNMT3B -0.39 -5.92 -0.31 8.02e-9 Subjective well-being; CRC cis rs6460942 0.908 rs77799203 chr7:12264432 C/G cg06484146 chr7:12443880 VWDE -0.63 -6.47 -0.34 3.48e-10 Coronary artery disease; CRC cis rs6952808 0.595 rs3778983 chr7:2166319 T/G cg21782813 chr7:2030301 MAD1L1 0.49 8.49 0.42 7.13e-16 Bipolar disorder and schizophrenia; CRC cis rs2075671 0.903 rs11520986 chr7:100276994 A/G cg16850897 chr7:100343110 ZAN -0.61 -9.1 -0.45 8.77e-18 Other erythrocyte phenotypes; CRC cis rs7824557 0.564 rs2736295 chr8:11234780 C/G cg20542592 chr8:11973495 FAM66D -0.35 -6.31 -0.33 9.06e-10 Retinal vascular caliber; CRC cis rs6951245 0.507 rs11976805 chr7:1138716 C/T cg23978390 chr7:1156363 C7orf50 0.62 7.67 0.39 2.02e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs1983170 1.000 rs597288 chr1:91999296 C/T cg02896835 chr1:92012615 NA 0.48 6.5 0.34 2.97e-10 Eosinophil percentage of white cells; CRC trans rs561341 1.000 rs8064843 chr17:30245744 A/G cg20587970 chr11:113659929 NA -0.92 -13.1 -0.59 7.4e-32 Hip circumference adjusted for BMI; CRC cis rs6460942 1.000 rs62448566 chr7:12403662 G/A cg20607287 chr7:12443886 VWDE -0.67 -6.78 -0.35 5.55e-11 Coronary artery disease; CRC trans rs10411161 1.000 rs3848562 chr19:52379835 C/T cg22319618 chr22:45562946 NUP50 0.54 5.98 0.31 5.78e-9 Breast cancer; CRC cis rs172166 0.516 rs1225715 chr6:28113373 C/T cg12273811 chr6:28175739 NA -0.45 -6.68 -0.35 1.05e-10 Cardiac Troponin-T levels; CRC cis rs2075371 0.830 rs2077671 chr7:133951204 C/T cg02659138 chr7:134003124 SLC35B4 0.36 6.24 0.33 1.33e-9 Mean platelet volume; CRC cis rs7618915 0.547 rs11720432 chr3:52672742 T/C cg05573699 chr3:52720067 GNL3;PBRM1 -0.45 -6.31 -0.33 8.81e-10 Bipolar disorder; CRC cis rs10504229 0.683 rs2088217 chr8:58113124 C/T cg05313129 chr8:58192883 C8orf71 -0.42 -5.85 -0.31 1.16e-8 Developmental language disorder (linguistic errors); CRC cis rs10256972 0.567 rs2960835 chr7:1202963 A/G cg03188948 chr7:1209495 NA 0.55 8.16 0.41 7.34e-15 Longevity;Endometriosis; CRC trans rs2727020 0.612 rs9787891 chr11:49413494 G/A cg11707556 chr5:10655725 ANKRD33B -0.37 -5.97 -0.31 6.15e-9 Coronary artery disease; CRC cis rs9660180 0.620 rs34298494 chr1:1663402 A/C cg13866156 chr1:1669148 SLC35E2 0.7 10.97 0.52 4.52e-24 Body mass index; CRC cis rs501120 0.810 rs474281 chr10:44749120 T/C cg09554077 chr10:44749378 NA 0.91 13.08 0.58 9.13e-32 Coronary artery disease;Coronary heart disease; CRC cis rs611744 0.631 rs627392 chr8:109254677 C/T cg21045802 chr8:109455806 TTC35 0.42 6.65 0.34 1.24e-10 Dupuytren's disease; CRC cis rs10504229 0.593 rs113184543 chr8:58042950 A/G cg02290350 chr8:58132656 NA -0.39 -5.63 -0.3 3.77e-8 Developmental language disorder (linguistic errors); CRC cis rs7771547 0.519 rs12663882 chr6:36362441 G/T cg07856975 chr6:36356162 ETV7 -0.47 -6.09 -0.32 3.21e-9 Platelet distribution width; CRC cis rs6860806 0.507 rs270601 chr5:131656997 T/C cg09877947 chr5:131593287 PDLIM4 0.45 7.23 0.37 3.51e-12 Breast cancer; CRC cis rs7618915 0.798 rs353547 chr3:52268866 A/G cg18404041 chr3:52824283 ITIH1 0.31 5.74 0.3 2.21e-8 Bipolar disorder; CRC cis rs11724804 0.532 rs62297079 chr4:879977 G/A cg23939001 chr4:940644 TMEM175 0.73 13.65 0.6 6.56e-34 Primary biliary cholangitis;Limited cutaneous systemic scleroderma; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg02008025 chr2:102314465 MAP4K4 0.43 6.0 0.31 5.26e-9 Response to antipsychotic treatment; CRC cis rs2836974 0.965 rs8130984 chr21:40639966 A/C cg11890956 chr21:40555474 PSMG1 1.1 19.01 0.72 6.7e-55 Cognitive function; CRC cis rs514406 0.825 rs9661082 chr1:53245472 A/T cg25767906 chr1:53392781 SCP2 0.45 7.22 0.37 3.55e-12 Monocyte count; CRC cis rs10540 1.000 rs61876336 chr11:489537 C/T cg19913688 chr11:428466 ANO9 -0.73 -7.41 -0.38 1.08e-12 Body mass index; CRC cis rs7568498 0.517 rs11678856 chr2:161925443 C/T cg22496339 chr2:162101262 NA -0.58 -8.28 -0.42 3.05e-15 Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 3 peripheral neuropathy); CRC cis rs17401966 0.931 rs17410217 chr1:10371854 A/G cg19773385 chr1:10388646 KIF1B -0.67 -10.18 -0.49 2.34e-21 Hepatocellular carcinoma; CRC cis rs59104589 0.535 rs73002160 chr2:242321707 A/C cg19488206 chr2:242435732 STK25 0.47 6.69 0.35 9.9e-11 Fibrinogen levels; CRC cis rs9322193 0.923 rs9322197 chr6:149943713 C/A cg05861140 chr6:150128134 PCMT1 -0.42 -6.86 -0.35 3.4e-11 Lung cancer; CRC cis rs9914988 0.943 rs2046759 chr17:27138817 T/C cg16670446 chr17:27188758 MIR451;MIR144 0.54 8.51 0.42 6.33e-16 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs6424115 0.830 rs6663474 chr1:24199642 G/A cg10978503 chr1:24200527 CNR2 0.62 11.34 0.53 2.16e-25 Immature fraction of reticulocytes; CRC cis rs3733585 0.598 rs28677023 chr4:9958326 C/A cg00071950 chr4:10020882 SLC2A9 -0.54 -9.65 -0.47 1.42e-19 Cleft plate (environmental tobacco smoke interaction); CRC cis rs7809950 1.000 rs17154104 chr7:107090698 C/T cg23024343 chr7:107201750 COG5 -0.63 -8.87 -0.44 4.67e-17 Coronary artery disease; CRC cis rs736408 0.562 rs2072390 chr3:52780509 A/T cg11645453 chr3:52864694 ITIH4 0.36 6.43 0.33 4.42e-10 Bipolar disorder; CRC cis rs60871478 0.947 rs4074610 chr7:791755 G/A cg05535760 chr7:792225 HEATR2 0.8 10.52 0.5 1.68e-22 Cerebrospinal P-tau181p levels; CRC trans rs7267979 1.000 rs1047171 chr20:25428786 T/C cg17903999 chr18:56338584 MALT1 -0.42 -6.98 -0.36 1.6e-11 Liver enzyme levels (alkaline phosphatase); CRC cis rs9457247 0.508 rs6902119 chr6:167505791 T/C cg07741184 chr6:167504864 NA 0.37 6.7 0.35 9.13e-11 Crohn's disease; CRC trans rs6472235 0.837 rs6992002 chr8:66927237 G/A cg07884673 chr3:53033167 SFMBT1 -0.45 -6.03 -0.32 4.47e-9 Myopia (pathological);Plateletcrit; CRC cis rs8044995 0.563 rs73613962 chr16:68361974 T/G cg09835421 chr16:68378352 PRMT7 -0.79 -7.91 -0.4 4e-14 Schizophrenia; CRC cis rs853679 0.550 rs34477097 chr6:28197186 C/T cg12172441 chr6:28176163 NA 0.55 6.96 0.36 1.9e-11 Depression; CRC cis rs10256972 0.706 rs12701969 chr7:1121849 A/G cg27094323 chr7:1216898 NA -0.39 -6.18 -0.32 1.93e-9 Longevity;Endometriosis; CRC cis rs2882667 0.690 rs6877187 chr5:138159344 T/C cg09476006 chr5:138032270 NA -0.58 -10.51 -0.5 1.8e-22 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs9311474 0.508 rs6786919 chr3:52599789 A/G cg10802521 chr3:52805072 NEK4 -0.56 -8.89 -0.44 4e-17 Electroencephalogram traits; CRC cis rs2836950 0.762 rs8134638 chr21:40644170 T/C cg06238570 chr21:40685208 BRWD1 -0.44 -5.62 -0.3 4.17e-8 Menarche (age at onset); CRC cis rs3785574 0.962 rs7219920 chr17:61811642 C/G cg06601766 chr17:61851465 DDX42;CCDC47 0.58 8.33 0.42 2.19e-15 Height; CRC cis rs2991971 1.000 rs622798 chr1:46015271 T/G cg24296786 chr1:45957014 TESK2 0.49 6.97 0.36 1.75e-11 High light scatter reticulocyte count; CRC cis rs644799 0.687 rs3748252 chr11:95519195 A/T cg25478527 chr11:95522999 CEP57;FAM76B -0.5 -7.73 -0.39 1.32e-13 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs881375 0.967 rs7875829 chr9:123660398 A/G cg14255062 chr9:123606675 PSMD5;LOC253039 0.42 6.07 0.32 3.48e-9 Rheumatoid arthritis; CRC cis rs4713675 0.649 rs568901 chr6:33710038 A/G cg07979401 chr6:33739406 LEMD2 0.38 5.65 0.3 3.51e-8 Plateletcrit; CRC cis rs2197308 0.631 rs4882308 chr12:38446252 G/C cg26384229 chr12:38710491 ALG10B -0.51 -7.34 -0.37 1.73e-12 Morning vs. evening chronotype; CRC cis rs7739232 0.920 rs79279936 chr6:53529471 C/T cg15658676 chr6:53530538 KLHL31 -0.76 -5.9 -0.31 8.9e-9 Hip circumference adjusted for BMI; CRC cis rs514406 0.830 rs533935 chr1:53308807 T/C cg24675658 chr1:53192096 ZYG11B -0.57 -8.56 -0.43 4.51e-16 Monocyte count; CRC cis rs7811142 1.000 rs68116612 chr7:100006493 G/A cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.75 10.77 0.51 2.32e-23 Platelet count; CRC cis rs9399137 0.507 rs6940258 chr6:135366132 C/T cg22676075 chr6:135203613 NA 0.55 8.13 0.41 8.74e-15 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; CRC cis rs10504229 1.000 rs68076606 chr8:58191271 A/G cg02725872 chr8:58115012 NA -0.38 -6.43 -0.33 4.44e-10 Developmental language disorder (linguistic errors); CRC cis rs2573652 1.000 rs2727195 chr15:100513117 G/A cg00587665 chr15:100533223 ADAMTS17 -0.37 -6.14 -0.32 2.33e-9 Height; CRC cis rs3858526 0.883 rs7481882 chr11:5944221 A/G cg05234568 chr11:5960015 NA -0.53 -7.06 -0.36 9.76e-12 DNA methylation (variation); CRC cis rs4862750 0.914 rs1346127 chr4:187876389 C/T cg03452623 chr4:187889614 NA 0.87 19.41 0.73 1.78e-56 Lobe attachment (rater-scored or self-reported); CRC trans rs116095464 0.558 rs9312977 chr5:221916 G/C cg00938859 chr5:1591904 SDHAP3 0.68 7.39 0.38 1.24e-12 Breast cancer; CRC cis rs6951245 1.000 rs79617366 chr7:1111958 G/C cg04025307 chr7:1156635 C7orf50 0.67 7.14 0.37 5.93e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC trans rs67340775 0.541 rs200965 chr6:27866384 G/A cg06606381 chr12:133084897 FBRSL1 -0.65 -6.37 -0.33 6.45e-10 Lung cancer in ever smokers; CRC cis rs6089584 0.566 rs2146852 chr20:60616492 T/G cg13770153 chr20:60521292 NA -0.47 -7.16 -0.37 5.17e-12 Body mass index; CRC cis rs9916302 0.784 rs4795382 chr17:37700860 A/G cg03013999 chr17:37608204 MED1 0.46 7.14 0.37 5.87e-12 Glomerular filtration rate (creatinine); CRC cis rs7191700 0.511 rs12923756 chr16:11359675 C/T cg00044050 chr16:11439710 C16orf75 -0.55 -7.96 -0.4 2.84e-14 Multiple sclerosis; CRC cis rs7914558 1.000 rs7071373 chr10:104771922 A/G cg04362960 chr10:104952993 NT5C2 0.6 9.04 0.45 1.33e-17 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs7811142 0.775 rs6946768 chr7:99954393 G/A cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.13 15.39 0.65 1.27e-40 Platelet count; CRC cis rs4665809 1.000 rs6720314 chr2:26334852 G/A cg25036284 chr2:26402008 FAM59B -0.47 -5.82 -0.31 1.38e-8 Gut microbiome composition (summer); CRC cis rs2979489 0.891 rs4537262 chr8:30306757 T/A cg26383811 chr8:30366931 RBPMS 0.7 9.85 0.48 3.22e-20 Mean corpuscular hemoglobin;Plateletcrit;Neutrophil count;Granulocyte count;Sum basophil neutrophil counts;Mean corpuscular volume;Myeloid white cell count;Sum neutrophil eosinophil counts; CRC trans rs916888 0.697 rs199516 chr17:44856485 C/T cg07870213 chr5:140052090 DND1 -0.85 -10.09 -0.49 4.87e-21 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs35110281 0.744 rs162373 chr21:44927107 C/A cg01579765 chr21:45077557 HSF2BP 0.34 6.38 0.33 6.16e-10 Mean corpuscular volume; CRC cis rs10489202 0.608 rs7556350 chr1:168077797 C/T cg24449463 chr1:168025552 DCAF6 -0.52 -7.29 -0.37 2.32e-12 Schizophrenia; CRC cis rs7584330 0.697 rs60278044 chr2:238357118 A/G cg16989719 chr2:238392110 NA -0.46 -8.72 -0.43 1.43e-16 Prostate cancer; CRC cis rs1448094 0.512 rs11117060 chr12:86250788 G/T cg25456477 chr12:86230367 RASSF9 -0.34 -6.07 -0.32 3.54e-9 Major depressive disorder; CRC cis rs9837602 0.529 rs793495 chr3:99507934 A/G cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G 0.47 6.29 0.33 9.84e-10 Breast cancer; CRC cis rs1030268 0.651 rs12707121 chr7:133496379 A/G cg10665199 chr7:133106180 EXOC4 0.55 6.22 0.32 1.5e-9 Intelligence (multi-trait analysis); CRC cis rs1832871 0.711 rs6920506 chr6:158695017 T/A cg07165851 chr6:158734300 TULP4 0.6 7.58 0.39 3.46e-13 Height; CRC cis rs875971 0.862 rs6460282 chr7:65691246 T/C cg18876405 chr7:65276391 NA -0.54 -8.68 -0.43 1.93e-16 Aortic root size; CRC trans rs3942852 0.868 rs7118232 chr11:48106274 T/C cg03929089 chr4:120376271 NA -0.55 -6.39 -0.33 5.6e-10 Acute lymphoblastic leukemia (childhood); CRC cis rs1448094 0.511 rs1993807 chr12:86146833 A/G cg00310523 chr12:86230176 RASSF9 -0.36 -5.92 -0.31 8.25e-9 Major depressive disorder; CRC cis rs2688608 0.592 rs7908825 chr10:75554541 C/G cg16540259 chr10:75572220 NDST2 -0.38 -6.03 -0.32 4.36e-9 Inflammatory bowel disease; CRC cis rs704795 0.836 rs1647281 chr2:27612938 G/C cg02592271 chr2:27665507 KRTCAP3 -0.26 -5.98 -0.31 5.78e-9 Menopause (age at onset); CRC cis rs734999 0.545 rs3890745 chr1:2553624 C/T cg20673091 chr1:2541236 MMEL1 -0.36 -5.91 -0.31 8.39e-9 Ulcerative colitis; CRC cis rs2976388 0.590 rs10087426 chr8:143814554 G/A cg15511327 chr8:143859410 LYNX1 -0.39 -6.56 -0.34 2.13e-10 Urinary tract infection frequency; CRC cis rs2075371 0.897 rs12667905 chr7:134000812 A/C cg02659138 chr7:134003124 SLC35B4 0.42 7.06 0.36 9.8e-12 Mean platelet volume; CRC cis rs2075371 0.932 rs11766132 chr7:133993062 T/C cg11752832 chr7:134001865 SLC35B4 0.44 6.49 0.34 3.07e-10 Mean platelet volume; CRC cis rs1568889 1.000 rs12791341 chr11:28335452 T/C cg06544937 chr11:28130018 METT5D1;KIF18A 0.79 11.01 0.52 3.15e-24 Bipolar disorder; CRC cis rs4713118 0.513 rs202908 chr6:28011551 C/G cg15786705 chr6:28176104 NA 0.6 8.65 0.43 2.29e-16 Parkinson's disease; CRC cis rs4474465 0.850 rs4482052 chr11:78263331 A/G cg02023728 chr11:77925099 USP35 -0.36 -6.15 -0.32 2.29e-9 Alzheimer's disease (survival time); CRC cis rs2252521 0.524 rs317744 chr7:29067293 T/G cg11728747 chr7:29037910 CPVL -0.5 -7.21 -0.37 3.86e-12 Cognitive performance; CRC cis rs11123170 0.640 rs1015754 chr2:113967990 T/C cg21482265 chr2:113992762 PAX8;LOC440839;LOC654433 -0.54 -7.25 -0.37 2.96e-12 Renal function-related traits (BUN); CRC cis rs2836974 0.897 rs35123057 chr21:40711689 C/T cg11644478 chr21:40555479 PSMG1 0.73 10.47 0.5 2.51e-22 Cognitive function; CRC cis rs4285028 0.747 rs9838301 chr3:121375144 G/T cg20356878 chr3:121714668 ILDR1 -0.43 -5.92 -0.31 7.9e-9 Multiple sclerosis; CRC cis rs12477438 0.520 rs6739579 chr2:99731552 C/T cg14399236 chr2:99771627 LIPT1;TSGA10 0.82 14.35 0.62 1.29e-36 Chronic sinus infection; CRC cis rs11758351 1.000 rs77957229 chr6:26185226 A/G cg00620190 chr6:26240307 HIST1H4F -0.48 -5.89 -0.31 9.69e-9 Gout;Renal underexcretion gout; CRC cis rs6860806 0.507 rs270601 chr5:131656997 T/C cg12564285 chr5:131593104 PDLIM4 0.46 7.69 0.39 1.75e-13 Breast cancer; CRC cis rs11585357 1.000 rs11585357 chr1:17601165 C/T cg08277548 chr1:17600880 PADI3 -0.95 -12.45 -0.57 2.06e-29 Hair shape; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg09376352 chr11:119076657 CBL -0.41 -6.0 -0.31 5.14e-9 Myopia (pathological); CRC cis rs28386778 0.897 rs1043127 chr17:61791210 T/G cg11494091 chr17:61959527 GH2 0.61 10.28 0.49 1.08e-21 Prudent dietary pattern; CRC cis rs34172651 0.917 rs11074651 chr16:24778409 A/G cg06028605 chr16:24865363 SLC5A11 0.39 7.55 0.38 4.28e-13 Intelligence (multi-trait analysis); CRC cis rs2274273 0.624 rs12050123 chr14:55840386 G/A cg10130446 chr14:55658398 DLGAP5 -0.43 -6.13 -0.32 2.46e-9 Protein biomarker; CRC cis rs11608355 0.545 rs7316375 chr12:109906998 G/C cg05360138 chr12:110035743 NA 0.77 8.61 0.43 3.16e-16 Neuroticism; CRC cis rs10744422 0.925 rs2880678 chr12:123317099 C/T cg25930673 chr12:123319894 HIP1R -0.56 -6.1 -0.32 2.96e-9 Schizophrenia; CRC cis rs3740540 0.530 rs2362503 chr10:126290538 T/C cg04949429 chr10:126290192 LHPP 0.43 6.36 0.33 6.86e-10 Obesity-related traits;Acute lymphoblastic leukemia (childhood); CRC cis rs59698941 0.550 rs11748063 chr5:132200943 C/T cg14825688 chr5:132208181 LEAP2 -0.41 -6.64 -0.34 1.32e-10 Apolipoprotein A-IV levels; CRC cis rs2463822 0.514 rs10750972 chr11:62053687 A/G cg06239285 chr11:62104954 ASRGL1 0.58 7.02 0.36 1.3e-11 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs7119 0.604 rs2682927 chr15:77859168 C/T cg10437265 chr15:77819839 NA -0.47 -7.67 -0.39 2.02e-13 Type 2 diabetes; CRC cis rs13118159 0.899 rs3796613 chr4:1353321 A/T cg19318889 chr4:1322082 MAEA 0.51 7.58 0.39 3.63e-13 Longevity; CRC cis rs11190604 1.000 rs10883497 chr10:102228519 A/G cg16342193 chr10:102329863 NA -0.37 -5.96 -0.31 6.66e-9 Palmitoleic acid (16:1n-7) levels; CRC cis rs669446 0.528 rs7538463 chr1:44196416 T/A cg12908607 chr1:44402522 ARTN -0.34 -5.85 -0.31 1.17e-8 Amyotrophic lateral sclerosis (age of onset); CRC cis rs12347191 0.500 rs907579 chr9:100622723 G/T cg13688889 chr9:100608707 NA -0.47 -5.92 -0.31 8.1e-9 Orofacial clefts; CRC trans rs561341 0.883 rs1034626 chr17:30219500 C/G cg27661571 chr11:113659931 NA 0.62 7.53 0.38 4.94e-13 Hip circumference adjusted for BMI; CRC cis rs56091001 0.528 rs9616387 chr22:50313219 G/A cg08270630 chr22:50330655 NA -0.66 -6.38 -0.33 6.04e-10 Acne (severe); CRC cis rs4728302 0.838 rs7798804 chr7:133584085 C/T cg03336402 chr7:133662267 EXOC4 -0.44 -6.37 -0.33 6.27e-10 Intelligence;Intelligence (multi-trait analysis); CRC cis rs4555082 0.874 rs2816613 chr14:105726367 C/T cg18132624 chr14:105716052 BTBD6;BRF1 -0.46 -7.34 -0.38 1.67e-12 Mean platelet volume;Platelet distribution width; CRC cis rs4629180 0.920 rs4851458 chr2:102108794 T/C cg01388757 chr2:102091195 RFX8 -0.61 -8.22 -0.41 4.67e-15 Chronic rhinosinusitis with nasal polyps; CRC cis rs6120849 0.754 rs1885117 chr20:33600740 C/T cg24642439 chr20:33292090 TP53INP2 0.43 5.61 0.3 4.4e-8 Protein C levels; CRC cis rs9467603 1.000 rs9467613 chr6:25812641 T/C cg16898833 chr6:26189333 HIST1H4D 0.77 6.45 0.33 4.07e-10 Intelligence (multi-trait analysis); CRC cis rs7781266 0.739 rs62469985 chr7:133218084 C/T cg03336402 chr7:133662267 EXOC4 0.47 5.61 0.3 4.3e-8 Educational attainment (college completion); CRC cis rs2153535 0.601 rs718504 chr6:8527512 A/G cg07606381 chr6:8435919 SLC35B3 0.68 11.04 0.52 2.51e-24 Motion sickness; CRC cis rs6912958 0.515 rs381782 chr6:88040649 C/T cg08069147 chr6:88032118 GJB7;C6orf162 0.75 12.12 0.56 3.32e-28 Monocyte percentage of white cells; CRC trans rs2303319 0.504 rs62187655 chr2:162487440 C/G cg06896663 chr8:82754093 SNX16 -0.69 -5.96 -0.31 6.54e-9 Cognitive function; CRC cis rs9463078 0.739 rs6458425 chr6:45173857 C/G cg25276700 chr6:44698697 NA -0.24 -5.77 -0.3 1.79e-8 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; CRC cis rs763121 0.853 rs2267395 chr22:39113903 C/T cg06544989 chr22:39130855 UNC84B 0.5 7.84 0.4 6.37e-14 Menopause (age at onset); CRC cis rs798554 0.679 rs2533870 chr7:2885274 C/G cg04166393 chr7:2884313 GNA12 -0.51 -6.92 -0.36 2.32e-11 Height; CRC cis rs270601 0.710 rs371709 chr5:131583240 A/G cg27615366 chr5:131592974 PDLIM4 0.32 5.65 0.3 3.42e-8 Acylcarnitine levels; CRC cis rs11105298 0.891 rs3825330 chr12:89933710 C/T cg08166232 chr12:89918718 WDR51B;GALNT4 -0.6 -7.28 -0.37 2.4e-12 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; CRC cis rs2228479 1.000 rs11642267 chr16:89957635 T/C cg12064134 chr16:90016061 DEF8 -0.69 -6.14 -0.32 2.38e-9 Skin colour saturation; CRC cis rs780096 0.526 rs1406295 chr2:27689700 A/G cg17158414 chr2:27665306 KRTCAP3 -0.3 -6.68 -0.35 9.98e-11 Total body bone mineral density; CRC trans rs4586057 0.812 rs7085559 chr10:92650119 T/C cg26894278 chr13:21016241 CRYL1 0.39 6.47 0.34 3.52e-10 Economic and political preferences (time); CRC cis rs1499614 1.000 rs1267818 chr7:66107024 C/T cg18252515 chr7:66147081 NA -1.26 -14.74 -0.63 4.13e-38 Gout; CRC cis rs7587476 0.784 rs62202001 chr2:215690359 C/G cg04004882 chr2:215674386 BARD1 0.66 9.22 0.45 3.72e-18 Neuroblastoma; CRC cis rs2153535 0.541 rs1414352 chr6:8485547 A/C cg07606381 chr6:8435919 SLC35B3 0.68 10.89 0.51 8.84e-24 Motion sickness; CRC cis rs4713118 0.513 rs202908 chr6:28011551 C/G cg20615401 chr6:28092323 ZSCAN16 0.45 6.06 0.32 3.66e-9 Parkinson's disease; CRC cis rs858239 1.000 rs199348 chr7:23293098 C/A cg00469287 chr7:23338798 C7orf30 0.44 5.87 0.31 1.06e-8 Cerebrospinal fluid biomarker levels; CRC cis rs7258465 1.000 rs2007981 chr19:18567555 C/A cg10790698 chr19:18539756 SSBP4 -0.44 -8.43 -0.42 1.08e-15 Breast cancer; CRC cis rs459571 0.959 rs2520100 chr9:136918137 A/T cg13789015 chr9:136890014 NCRNA00094 0.43 5.77 0.3 1.83e-8 Platelet distribution width; CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg02895995 chr19:7554069 PEX11G -0.49 -5.96 -0.31 6.34e-9 Diisocyanate-induced asthma; CRC cis rs11608355 0.545 rs2302704 chr12:109898797 A/G cg05360138 chr12:110035743 NA 0.76 8.56 0.43 4.51e-16 Neuroticism; CRC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg05917416 chr14:70826434 COX16 -0.43 -6.03 -0.32 4.3e-9 Asthma; CRC trans rs116095464 0.558 rs13357299 chr5:242211 T/C cg00938859 chr5:1591904 SDHAP3 0.67 7.32 0.37 1.95e-12 Breast cancer; CRC cis rs4713118 0.513 rs149959 chr6:28013854 T/C cg15786705 chr6:28176104 NA 0.57 8.1 0.41 1.11e-14 Parkinson's disease; CRC cis rs6564851 0.506 rs56291739 chr16:81258372 C/T cg05274606 chr16:81253692 PKD1L2 -0.35 -5.66 -0.3 3.32e-8 Carotenoid and tocopherol levels; CRC cis rs274567 0.550 rs272885 chr5:131667736 A/G cg12564285 chr5:131593104 PDLIM4 0.44 7.52 0.38 5.12e-13 Blood metabolite levels; CRC cis rs17253792 0.822 rs7145064 chr14:56088860 C/T cg01858014 chr14:56050164 KTN1 -0.87 -7.23 -0.37 3.36e-12 Putamen volume; CRC cis rs10256972 0.732 rs1574108 chr7:1105805 T/C cg02869364 chr7:1081709 C7orf50 -0.37 -5.61 -0.3 4.32e-8 Longevity;Endometriosis; CRC cis rs875971 0.964 rs2277911 chr7:65958625 T/G cg18876405 chr7:65276391 NA 0.52 8.9 0.44 3.86e-17 Aortic root size; CRC cis rs9467603 1.000 rs9467603 chr6:25803712 A/G cg16898833 chr6:26189333 HIST1H4D 0.77 6.45 0.33 4.07e-10 Intelligence (multi-trait analysis); CRC cis rs7725052 0.609 rs11955354 chr5:40457459 G/A cg09067459 chr5:40385259 NA -0.4 -6.58 -0.34 1.86e-10 Pediatric autoimmune diseases; CRC cis rs738322 0.839 rs133015 chr22:38572526 C/G cg25457927 chr22:38595422 NA -0.38 -7.98 -0.4 2.46e-14 Cutaneous nevi; CRC cis rs2204008 0.665 rs11495668 chr12:38221018 C/T cg13010199 chr12:38710504 ALG10B 0.44 5.62 0.3 4.1e-8 Bladder cancer; CRC cis rs736801 0.808 rs72797303 chr5:131796163 T/C cg00255919 chr5:131827918 IRF1 -0.37 -6.28 -0.33 1.07e-9 Breast cancer;Mosquito bite size; CRC cis rs9467711 0.606 rs9379858 chr6:26367689 T/C cg14345882 chr6:26364793 BTN3A2 0.65 5.74 0.3 2.17e-8 Autism spectrum disorder or schizophrenia; CRC cis rs642858 1.000 rs646695 chr6:140280398 C/T cg27524944 chr6:140295369 NA -0.34 -5.72 -0.3 2.37e-8 Type 2 diabetes; CRC trans rs13046373 0.905 rs4816372 chr21:32077414 A/T cg17987601 chr16:30389834 SEPT1 -0.41 -6.07 -0.32 3.51e-9 HDL cholesterol; CRC cis rs4604732 0.631 rs11490199 chr1:247625737 A/G cg12754571 chr1:247694271 LOC148824;OR2C3 0.41 5.78 0.3 1.74e-8 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CRC trans rs9291683 0.588 rs6857693 chr4:10018435 G/A cg26043149 chr18:55253948 FECH 0.51 7.91 0.4 3.95e-14 Bone mineral density; CRC cis rs9399135 0.935 rs4273704 chr6:135297520 G/T cg22676075 chr6:135203613 NA 0.43 6.69 0.35 9.9e-11 Red blood cell count; CRC cis rs3736594 0.513 rs2384627 chr2:27774449 G/A cg27432699 chr2:27873401 GPN1 0.66 8.49 0.42 7.24e-16 Fasting blood glucose;Fasting blood glucose (BMI interaction); CRC cis rs1215050 1.000 rs1215050 chr4:98849826 A/G cg05340658 chr4:99064831 C4orf37 -0.45 -6.36 -0.33 6.84e-10 Waist-to-hip ratio adjusted for body mass index; CRC cis rs3796619 1.000 rs55741287 chr4:1094670 T/C cg11579758 chr4:1086637 RNF212 0.41 6.84 0.35 3.85e-11 Recombination rate (males); CRC cis rs2243480 1.000 rs6460260 chr7:65215455 T/C cg12463550 chr7:65579703 CRCP -0.67 -6.13 -0.32 2.58e-9 Diabetic kidney disease; CRC cis rs17376456 0.877 rs10476596 chr5:93367074 C/T cg25358565 chr5:93447407 FAM172A -1.04 -10.38 -0.5 5.25e-22 Diabetic retinopathy; CRC cis rs28386778 0.897 rs1062788 chr17:61896127 C/G cg06873352 chr17:61820015 STRADA 0.77 14.46 0.62 5e-37 Prudent dietary pattern; CRC trans rs6550704 0.687 rs9865314 chr3:22634337 A/G cg09564133 chr5:176738847 MXD3 -0.41 -6.12 -0.32 2.68e-9 Daytime sleep phenotypes; CRC trans rs800082 1.000 rs9817588 chr3:144288302 A/T cg24215973 chr2:240111563 HDAC4 -0.52 -6.94 -0.36 2.04e-11 Smoking behavior; CRC cis rs2243480 0.522 rs431168 chr7:65511604 G/T cg18252515 chr7:66147081 NA -1.08 -9.46 -0.46 5.95e-19 Diabetic kidney disease; CRC cis rs12220238 1.000 rs11000900 chr10:75918440 T/A cg19889307 chr10:75911429 ADK;AP3M1 0.62 6.1 0.32 2.94e-9 Soluble interleukin-2 receptor subunit alpha; CRC cis rs9522267 0.502 rs9522297 chr13:112234419 C/T cg10483660 chr13:112241077 NA -0.48 -8.99 -0.44 2.04e-17 Hepatitis; CRC trans rs2018683 1.000 rs4719963 chr7:29011064 A/G cg19402173 chr7:128379420 CALU 0.53 8.34 0.42 2.05e-15 Response to irinotecan and platinum-based chemotherapy in non-small-cell lung cancer; CRC cis rs6121246 0.697 rs7269866 chr20:30232504 G/A cg18721089 chr20:30220636 NA -0.42 -6.82 -0.35 4.31e-11 Mean corpuscular hemoglobin; CRC cis rs916888 0.610 rs199442 chr17:44820122 G/A cg15921436 chr17:44337874 NA 0.55 7.06 0.36 1.02e-11 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs4664293 0.867 rs12692563 chr2:160602811 A/G cg08347373 chr2:160653686 CD302 -0.47 -7.43 -0.38 9.32e-13 Monocyte percentage of white cells; CRC cis rs514406 0.708 rs514881 chr1:53336737 A/G cg24675658 chr1:53192096 ZYG11B 0.62 9.23 0.45 3.32e-18 Monocyte count; CRC cis rs548181 0.536 rs503287 chr11:125461788 C/T cg03464685 chr11:125439445 EI24 0.91 10.15 0.49 3.04e-21 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs6762 0.748 rs28735718 chr11:839629 A/G cg03116740 chr11:841335 TSPAN4;POLR2L -0.42 -7.1 -0.36 7.51e-12 Mean platelet volume; CRC cis rs2415984 0.562 rs1389604 chr14:46972218 C/A cg14871534 chr14:47121158 RPL10L 0.41 5.73 0.3 2.29e-8 Number of children ever born; CRC cis rs3772130 0.962 rs1318472 chr3:121556899 G/A cg20356878 chr3:121714668 ILDR1 0.52 8.18 0.41 6.23e-15 Cognitive performance; CRC cis rs7618915 0.571 rs7623199 chr3:52605974 C/T cg15147215 chr3:52552868 STAB1 -0.63 -10.56 -0.5 1.22e-22 Bipolar disorder; CRC cis rs6951245 1.000 rs1881123 chr7:1084706 C/T cg04025307 chr7:1156635 C7orf50 0.64 6.69 0.35 9.78e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg08120389 chr17:19881268 AKAP10 -0.41 -5.99 -0.31 5.64e-9 Myopia (pathological); CRC cis rs13108904 0.967 rs1316419 chr4:1293997 C/T cg21620606 chr4:1342894 KIAA1530 0.34 5.67 0.3 3.06e-8 Obesity-related traits; CRC cis rs1129187 0.755 rs7760250 chr6:42929839 G/A cg02353165 chr6:42928485 GNMT 0.7 11.98 0.55 1.1e-27 Alzheimer's disease in APOE e4+ carriers; CRC cis rs899997 1.000 rs11634628 chr15:79005579 G/A cg22753661 chr15:79092743 ADAMTS7 0.43 5.9 0.31 9.02e-9 Coronary artery disease or large artery stroke; CRC cis rs10791323 0.572 rs4353292 chr11:133742656 A/G cg15485101 chr11:133734466 NA 0.46 7.9 0.4 4.29e-14 Childhood ear infection; CRC cis rs1182436 1 rs1182436 chr7:157027753 T/C cg17757837 chr7:157058334 UBE3C -0.49 -6.38 -0.33 6.07e-10 Type 2 diabetes; CRC cis rs11212617 1.000 rs652311 chr11:108240069 G/A cg01991180 chr11:108092276 ATM;NPAT 0.44 6.62 0.34 1.5e-10 Response to metformin in type 2 diabetes (glycemic); CRC cis rs79349575 0.783 rs4793996 chr17:47019597 T/C cg00947319 chr17:47005597 UBE2Z -0.34 -5.89 -0.31 9.32e-9 Type 2 diabetes; CRC cis rs1862618 0.853 rs33325 chr5:56142547 G/C cg12311346 chr5:56204834 C5orf35 -0.79 -10.48 -0.5 2.21e-22 Initial pursuit acceleration; CRC cis rs2732480 0.500 rs7315820 chr12:48598938 C/T cg24011408 chr12:48396354 COL2A1 0.44 6.17 0.32 2.04e-9 Hemoglobin concentration;Red blood cell count;Hematocrit; CRC cis rs3796352 1.000 rs3796352 chr3:52913279 C/T cg06204229 chr3:52865917 ITIH4 0.52 5.86 0.31 1.14e-8 Immune reponse to smallpox (secreted IL-2); CRC cis rs13256369 0.802 rs11249887 chr8:8562184 T/C cg06636001 chr8:8085503 FLJ10661 0.49 6.24 0.33 1.31e-9 Obesity-related traits; CRC cis rs1552244 0.572 rs3843008 chr3:10173742 C/T cg00166722 chr3:10149974 C3orf24 0.7 7.36 0.38 1.47e-12 Alzheimer's disease; CRC cis rs875971 0.964 rs2161065 chr7:65932905 A/G cg11764359 chr7:65958608 NA 0.62 9.91 0.48 1.96e-20 Aortic root size; CRC cis rs2013441 0.866 rs62067558 chr17:20025706 G/T cg13482628 chr17:19912719 NA 0.4 5.77 0.3 1.82e-8 Obesity-related traits; CRC cis rs4481887 0.893 rs4576683 chr1:248472390 T/C cg13385794 chr1:248469461 NA 0.38 6.76 0.35 6.25e-11 Common traits (Other); CRC cis rs3771570 0.901 rs10190033 chr2:242412358 A/C cg21155796 chr2:242212141 HDLBP 0.6 7.02 0.36 1.27e-11 Prostate cancer; CRC cis rs7666738 1.000 rs1426673 chr4:98924024 G/A cg17366294 chr4:99064904 C4orf37 0.47 7.58 0.39 3.53e-13 Colonoscopy-negative controls vs population controls; CRC cis rs1018836 0.923 rs6986689 chr8:91626709 A/C cg16814680 chr8:91681699 NA -0.77 -12.18 -0.56 1.96e-28 Ejection fraction in Tripanosoma cruzi seropositivity; CRC cis rs2549003 0.966 rs2070730 chr5:131819800 G/A cg00255919 chr5:131827918 IRF1 0.59 11.92 0.55 1.77e-27 Asthma (sex interaction); CRC trans rs875971 0.660 rs2191268 chr7:66110224 C/T cg21765224 chr20:34359771 PHF20 -0.34 -5.96 -0.31 6.53e-9 Aortic root size; CRC cis rs929354 0.772 rs6967764 chr7:156994964 C/T cg16102536 chr7:156981717 UBE3C 0.4 6.77 0.35 5.77e-11 Body mass index; CRC cis rs7552404 1.000 rs11161510 chr1:76210289 A/G cg10523679 chr1:76189770 ACADM -0.83 -11.35 -0.53 1.99e-25 Blood metabolite levels;Acylcarnitine levels; CRC cis rs2032447 0.765 rs6942072 chr6:26014987 A/G cg26028573 chr6:26043587 HIST1H2BB 0.48 7.16 0.37 5.23e-12 Intelligence (multi-trait analysis); CRC trans rs10504229 0.906 rs7003276 chr8:58173089 A/T cg04077850 chr5:125800366 GRAMD3 0.36 6.13 0.32 2.47e-9 Developmental language disorder (linguistic errors); CRC cis rs7959452 0.590 rs56054057 chr12:69775972 C/T cg14784868 chr12:69753453 YEATS4 0.84 14.79 0.63 2.58e-38 Blood protein levels; CRC cis rs7772486 0.905 rs9373486 chr6:146446024 C/G cg13319975 chr6:146136371 FBXO30 0.4 6.11 0.32 2.82e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs7901135 0.962 rs3740451 chr10:60566137 G/A cg23799393 chr10:60588674 BICC1 0.37 5.67 0.3 3.2e-8 Morning vs. evening chronotype; CRC cis rs2108225 0.837 rs6466186 chr7:107446966 G/C cg18560240 chr7:107437656 SLC26A3 -0.58 -8.92 -0.44 3.3e-17 Ulcerative colitis; CRC cis rs1552244 1.000 rs7648104 chr3:10073311 C/A cg18598329 chr3:10140678 FANCD2;C3orf24 -0.89 -11.87 -0.55 2.69e-27 Alzheimer's disease; CRC cis rs7937682 0.632 rs7112886 chr11:111743232 T/C cg09085632 chr11:111637200 PPP2R1B 0.95 15.05 0.64 2.66e-39 Primary sclerosing cholangitis; CRC cis rs2398893 0.960 rs2153791 chr9:96744928 G/A cg14459158 chr9:96720562 NA 0.47 7.09 0.36 8.25e-12 Waist-hip ratio;Waist-to-hip ratio adjusted for body mass index; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg17097992 chr2:10443818 HPCAL1 0.44 6.07 0.32 3.45e-9 Anxiety disorder; CRC cis rs2153535 0.580 rs9406163 chr6:8466642 C/T cg21535247 chr6:8435926 SLC35B3 0.5 7.53 0.38 4.89e-13 Motion sickness; CRC trans rs4332037 0.901 rs7791899 chr7:1935988 T/C cg11693508 chr17:37793320 STARD3 0.7 8.45 0.42 9.26e-16 Bipolar disorder; CRC cis rs478304 0.754 rs2004649 chr11:65380916 G/A cg27068330 chr11:65405492 SIPA1 -0.63 -9.42 -0.46 7.97e-19 Acne (severe); CRC cis rs7107174 0.892 rs10899490 chr11:78105879 C/T cg02023728 chr11:77925099 USP35 0.46 7.77 0.39 9.97e-14 Testicular germ cell tumor; CRC trans rs7267979 1.000 rs2482940 chr20:25349830 C/T cg17903999 chr18:56338584 MALT1 0.41 6.65 0.34 1.24e-10 Liver enzyme levels (alkaline phosphatase); CRC trans rs7615952 0.546 rs2979340 chr3:125341384 C/T cg16558177 chr4:4109446 NA -0.56 -6.52 -0.34 2.73e-10 Blood pressure (smoking interaction); CRC cis rs10883723 0.810 rs11191304 chr10:104255284 C/T cg22532475 chr10:104410764 TRIM8 -0.37 -6.86 -0.35 3.51e-11 Allergic disease (asthma, hay fever or eczema); CRC cis rs208520 0.661 rs207099 chr6:66796373 A/C cg07460842 chr6:66804631 NA -1.08 -15.25 -0.64 4.51e-40 Exhaled nitric oxide output; CRC cis rs111326718 1 rs111326718 chr10:104771211 A/AAAAAT cg04362960 chr10:104952993 NT5C2 0.6 9.04 0.45 1.33e-17 Reticulocyte count; CRC cis rs11190604 1.000 rs2489047 chr10:102347028 A/G cg07080220 chr10:102295463 HIF1AN 0.49 6.21 0.32 1.62e-9 Palmitoleic acid (16:1n-7) levels; CRC cis rs2439831 0.850 rs544122 chr15:43775732 A/T cg02155558 chr15:43621948 ADAL;LCMT2 0.68 7.41 0.38 1.08e-12 Lung cancer in ever smokers; CRC trans rs7618501 0.571 rs2240329 chr3:50107512 G/A cg21665057 chr3:196295764 WDR53;FBXO45 -0.58 -9.26 -0.45 2.76e-18 Intelligence (multi-trait analysis); CRC cis rs1507153 0.651 rs9350781 chr6:79481815 A/T cg05283184 chr6:79620031 NA -0.41 -5.72 -0.3 2.35e-8 Sjögren's syndrome; CRC cis rs10479542 0.583 rs4131080 chr5:179044292 G/A cg00080972 chr5:178986291 RUFY1 0.42 7.56 0.38 3.93e-13 Lung cancer; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg14089728 chr14:24563796 PCK2 0.44 5.97 0.31 6.07e-9 Anxiety disorder; CRC cis rs11122272 0.735 rs2486727 chr1:231539245 A/G cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.57 -8.51 -0.42 6.05e-16 Hemoglobin concentration; CRC cis rs17065868 0.649 rs9533853 chr13:45020119 G/C cg10246903 chr13:45222710 NA 0.59 5.83 0.31 1.33e-8 Antineutrophil cytoplasmic antibody-associated vasculitis; CRC cis rs72781680 1.000 rs12616250 chr2:24211550 T/C cg08917208 chr2:24149416 ATAD2B 0.9 9.13 0.45 6.93e-18 Lymphocyte counts; CRC cis rs12476592 0.571 rs2176415 chr2:63636568 A/C cg10828910 chr2:63850056 LOC388955 0.55 6.54 0.34 2.39e-10 Childhood ear infection; CRC cis rs7666738 0.791 rs6840669 chr4:99016020 G/T cg05340658 chr4:99064831 C4orf37 0.62 9.64 0.47 1.5700000000000001e-19 Colonoscopy-negative controls vs population controls; CRC trans rs3733585 0.699 rs4276278 chr4:9948870 T/C cg26043149 chr18:55253948 FECH -0.47 -7.02 -0.36 1.26e-11 Cleft plate (environmental tobacco smoke interaction); CRC cis rs6701037 0.681 rs1057246 chr1:175127534 C/G cg14847009 chr1:175162515 KIAA0040 0.27 6.06 0.32 3.73e-9 Alcohol dependence; CRC cis rs5769765 0.862 rs9616380 chr22:50312225 T/C cg08270630 chr22:50330655 NA -0.4 -5.61 -0.3 4.4e-8 Schizophrenia; CRC cis rs7552404 0.727 rs12122939 chr1:76276353 T/C cg03433033 chr1:76189801 ACADM 0.69 9.1 0.45 8.88e-18 Blood metabolite levels;Acylcarnitine levels; CRC cis rs9916302 0.904 rs3744348 chr17:37417575 C/G cg15445000 chr17:37608096 MED1 0.41 8.9 0.44 3.82e-17 Glomerular filtration rate (creatinine); CRC cis rs7814319 0.838 rs10955067 chr8:97230982 C/T cg20787634 chr8:97240163 UQCRB -0.47 -8.36 -0.42 1.75e-15 Lung function (FVC); CRC cis rs6840360 0.642 rs1899550 chr4:152407236 T/C cg09659197 chr4:152720779 NA 0.34 6.65 0.34 1.24e-10 Intelligence (multi-trait analysis); CRC cis rs1799949 1.000 rs4793229 chr17:41418334 C/T cg01879757 chr17:41196368 BRCA1 0.43 6.45 0.33 4.11e-10 Menopause (age at onset); CRC cis rs1552244 0.882 rs13063929 chr3:10010308 T/C cg10729496 chr3:10149963 C3orf24 0.51 6.57 0.34 1.92e-10 Alzheimer's disease; CRC cis rs6582630 0.555 rs7305352 chr12:38473800 T/C cg26384229 chr12:38710491 ALG10B 0.71 9.5 0.46 4.39e-19 Drug-induced liver injury (flucloxacillin); CRC cis rs1552244 0.882 rs13089863 chr3:10032259 G/T cg13047869 chr3:10149882 C3orf24 -0.51 -6.67 -0.35 1.07e-10 Alzheimer's disease; CRC cis rs6089584 0.888 rs2181590 chr20:60622843 T/C cg23262073 chr20:60523788 NA -0.45 -7.08 -0.36 8.95e-12 Body mass index; CRC cis rs8072100 0.840 rs4968319 chr17:45464967 A/G cg25173405 chr17:45401733 C17orf57 -0.5 -8.01 -0.4 2.05e-14 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs1538970 0.924 rs7528573 chr1:45913860 T/C cg05343316 chr1:45956843 TESK2 0.75 9.93 0.48 1.69e-20 Platelet count; CRC cis rs910316 1.000 rs10142865 chr14:75555624 G/A cg08847533 chr14:75593920 NEK9 0.95 18.79 0.72 5e-54 Height; CRC trans rs6463739 1.000 rs6463731 chr7:7902895 G/T cg09417038 chr21:47716443 C21orf57 -0.43 -6.59 -0.34 1.75e-10 Small cell lung carcinoma; CRC cis rs644799 1.000 rs472231 chr11:95532166 A/G cg25478527 chr11:95522999 CEP57;FAM76B 0.51 7.69 0.39 1.68e-13 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC trans rs1005277 0.522 rs7072977 chr10:37940440 C/A cg17830980 chr10:43048298 ZNF37B -0.45 -6.87 -0.35 3.13e-11 Extrinsic epigenetic age acceleration; CRC cis rs2050392 0.767 rs2183175 chr10:30699336 A/G cg18806716 chr10:30721971 MAP3K8 0.66 9.87 0.48 2.6e-20 Inflammatory bowel disease; CRC cis rs6534441 0.727 rs312492 chr4:125448257 A/G cg21609808 chr4:125404261 NA -0.41 -5.96 -0.31 6.36e-9 Major depressive disorder; CRC cis rs17345786 0.511 rs1138818 chr3:101399583 C/G cg12386194 chr3:101231763 SENP7 0.49 7.11 0.36 7.34e-12 Colonoscopy-negative controls vs population controls; CRC cis rs2625529 0.586 rs2306489 chr15:72227471 G/A cg16672083 chr15:72433130 SENP8 0.43 6.19 0.32 1.81e-9 Red blood cell count; CRC cis rs11676348 0.935 rs6716276 chr2:218962205 A/G cg04731861 chr2:219085781 ARPC2 0.29 6.0 0.31 5.34e-9 Ulcerative colitis; CRC cis rs9826463 0.582 rs73238187 chr3:142143674 T/C cg20824294 chr3:142316082 PLS1 0.38 6.05 0.32 3.87e-9 QRS duration in Tripanosoma cruzi seropositivity; CRC cis rs6582630 0.638 rs4882309 chr12:38448595 A/G cg26384229 chr12:38710491 ALG10B -0.53 -7.68 -0.39 1.9e-13 Drug-induced liver injury (flucloxacillin); CRC cis rs10208940 0.920 rs72903979 chr2:68813938 C/T cg12452813 chr2:68675892 NA 0.48 6.0 0.31 5.28e-9 Urate levels in lean individuals; CRC cis rs916888 0.773 rs199445 chr17:44817408 C/T cg15921436 chr17:44337874 NA 0.79 8.68 0.43 1.93e-16 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs11997175 0.603 rs4291230 chr8:33674570 A/C cg04338863 chr8:33670619 NA -0.44 -6.43 -0.33 4.55e-10 Body mass index; CRC cis rs6582630 0.519 rs10880576 chr12:38497693 T/C cg13010199 chr12:38710504 ALG10B 0.47 6.35 0.33 7.33e-10 Drug-induced liver injury (flucloxacillin); CRC cis rs62064224 0.589 rs9889607 chr17:30785585 A/C cg09324608 chr17:30823087 MYO1D -0.34 -6.01 -0.31 4.83e-9 Schizophrenia; CRC trans rs10982213 0.830 rs2274163 chr9:117188714 C/T cg08980237 chr3:156534860 NA 0.38 6.3 0.33 9.79e-10 Interleukin-6 levels; CRC trans rs1005277 0.579 rs1740737 chr10:38499365 G/T cg17830980 chr10:43048298 ZNF37B -0.61 -10.09 -0.49 5.01e-21 Extrinsic epigenetic age acceleration; CRC trans rs4650994 0.525 rs4993304 chr1:178535144 A/G cg05059571 chr16:84539110 KIAA1609 -0.6 -8.21 -0.41 5.25e-15 HDL cholesterol levels;HDL cholesterol; CRC cis rs739401 0.611 rs417957 chr11:3046231 A/G cg25174290 chr11:3078921 CARS 0.44 6.88 0.35 3.1e-11 Longevity; CRC cis rs453301 0.658 rs6986044 chr8:8874786 G/C cg06636001 chr8:8085503 FLJ10661 -0.5 -7.43 -0.38 9.45e-13 Joint mobility (Beighton score); CRC cis rs8077889 0.871 rs17675370 chr17:41900030 T/C cg16892393 chr17:41919603 NA 0.59 8.52 0.43 5.92e-16 Triglycerides; CRC cis rs7568458 0.636 rs11126995 chr2:85792408 A/T cg02493740 chr2:85810744 VAMP5 -0.57 -8.65 -0.43 2.24e-16 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); CRC cis rs56283067 0.811 rs62435997 chr6:44692169 C/T cg18551225 chr6:44695536 NA -0.41 -5.92 -0.31 8.07e-9 Total body bone mineral density; CRC cis rs514406 0.929 rs515857 chr1:53336859 A/G cg08859206 chr1:53392774 SCP2 -0.4 -6.38 -0.33 6.17e-10 Monocyte count; CRC cis rs7517126 1.000 rs57809726 chr1:196841377 A/G cg13682187 chr1:196946512 CFHR5 -0.37 -5.97 -0.31 6.03e-9 Blood protein levels; CRC trans rs3942852 0.703 rs11039513 chr11:48107204 C/T cg03929089 chr4:120376271 NA 0.56 7.53 0.38 5.02e-13 Acute lymphoblastic leukemia (childhood); CRC cis rs17532515 0.628 rs3113195 chr4:141475837 A/G cg09181644 chr4:141490428 UCP1 -0.33 -5.98 -0.31 5.75e-9 Select biomarker traits; CRC trans rs2303319 0.504 rs62187612 chr2:162432494 A/G cg01422129 chr2:677375 TMEM18 -0.74 -6.01 -0.31 4.85e-9 Cognitive function; CRC cis rs904251 0.504 rs1757188 chr6:37483808 A/G cg01843034 chr6:37503916 NA -0.43 -8.11 -0.41 1.02e-14 Cognitive performance; CRC cis rs9910055 0.762 rs184478 chr17:42209751 C/G cg13607699 chr17:42295918 UBTF -0.49 -6.73 -0.35 7.58e-11 Total body bone mineral density; CRC cis rs13108904 0.870 rs4974545 chr4:1271923 C/T cg19318889 chr4:1322082 MAEA 0.41 5.87 0.31 1.05e-8 Obesity-related traits; CRC cis rs798554 0.797 rs798494 chr7:2798294 C/A cg13628971 chr7:2884303 GNA12 0.52 7.14 0.37 6.09e-12 Height; CRC cis rs72634501 0.716 rs72660086 chr1:39571992 T/G cg18385671 chr1:39797026 MACF1 -0.44 -6.02 -0.32 4.57e-9 HDL cholesterol; CRC cis rs6460942 1.000 rs6460942 chr7:12420989 T/C cg20607287 chr7:12443886 VWDE -0.62 -6.91 -0.36 2.48e-11 Coronary artery disease; CRC cis rs2836974 0.931 rs2776307 chr21:40713833 C/G cg11890956 chr21:40555474 PSMG1 -0.97 -15.21 -0.64 6.35e-40 Cognitive function; CRC trans rs12136737 0.826 rs6699949 chr1:184346908 C/T cg01883195 chr6:117802401 DCBLD1 0.56 6.2 0.32 1.65e-9 Colonoscopy-negative controls vs population controls; CRC trans rs17665859 0.669 rs55838337 chr8:447314 G/A cg18996590 chr8:30890583 WRN;PURG -0.45 -6.24 -0.33 1.33e-9 Bilirubin levels; CRC cis rs597539 0.652 rs604524 chr11:68629929 G/A cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.86 14.92 0.64 8.25e-39 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg09332974 chr1:113616366 LRIG2 0.49 6.92 0.36 2.38e-11 Response to antipsychotic treatment; CRC cis rs3733585 0.673 rs6836706 chr4:9964251 T/A cg11266682 chr4:10021025 SLC2A9 -0.47 -9.67 -0.47 1.2e-19 Cleft plate (environmental tobacco smoke interaction); CRC cis rs7619833 0.512 rs9858306 chr3:27222542 T/G cg02860705 chr3:27208620 NA 0.38 5.91 0.31 8.51e-9 Breast cancer; CRC cis rs4713118 0.628 rs9295740 chr6:27689502 G/A cg06470822 chr6:28175283 NA 0.51 6.04 0.32 4.06e-9 Parkinson's disease; CRC trans rs783540 0.967 rs2870966 chr15:83295244 G/A cg18393722 chr15:85113863 UBE2QP1 -0.37 -6.24 -0.33 1.34e-9 Schizophrenia; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg09517077 chr6:108880982 FOXO3 0.47 6.39 0.33 5.81e-10 Anxiety disorder; CRC cis rs2976388 0.609 rs2585149 chr8:143793320 T/C cg15511327 chr8:143859410 LYNX1 0.41 7.33 0.37 1.74e-12 Urinary tract infection frequency; CRC cis rs12024301 0.557 rs12024089 chr1:183608107 C/T cg11505048 chr1:183622726 RGL1;APOBEC4 0.77 6.73 0.35 7.45e-11 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs67311347 1.000 rs11715214 chr3:40403004 C/A cg24209194 chr3:40518798 ZNF619 0.38 5.66 0.3 3.28e-8 Renal cell carcinoma; CRC cis rs6545883 0.929 rs6705235 chr2:61713580 G/C cg15711740 chr2:61764176 XPO1 -0.43 -5.63 -0.3 3.8e-8 Tuberculosis; CRC cis rs6840360 1.000 rs10007167 chr4:152603655 C/T cg09659197 chr4:152720779 NA 0.49 9.56 0.47 2.83e-19 Intelligence (multi-trait analysis); CRC trans rs7615952 0.599 rs7652883 chr3:125707977 T/G cg07211511 chr3:129823064 LOC729375 -0.77 -10.89 -0.51 8.48e-24 Blood pressure (smoking interaction); CRC trans rs360798 0.512 rs2215870 chr2:63132342 C/G cg05376469 chr2:102649931 NA -0.38 -6.31 -0.33 9.25e-10 Coronary artery disease; CRC cis rs9527 0.590 rs10883834 chr10:104881402 T/C cg04362960 chr10:104952993 NT5C2 0.6 8.31 0.42 2.6e-15 Arsenic metabolism; CRC cis rs2836974 0.897 rs3945 chr21:40566067 A/G cg17971929 chr21:40555470 PSMG1 0.74 10.2 0.49 2.13e-21 Cognitive function; CRC cis rs892961 0.932 rs3987886 chr17:75414980 A/G cg05865280 chr17:75406074 SEPT9 0.62 13.95 0.61 4.63e-35 Airflow obstruction; CRC cis rs12983728 0.536 rs34380569 chr19:58648528 A/G cg24884572 chr19:58661833 ZNF329 0.47 5.87 0.31 1.05e-8 Cholesterol, total; CRC cis rs35110281 0.837 rs2838340 chr21:45076373 A/G cg01579765 chr21:45077557 HSF2BP -0.32 -6.1 -0.32 2.98e-9 Mean corpuscular volume; CRC cis rs7937682 0.632 rs11214015 chr11:111719417 A/T cg09085632 chr11:111637200 PPP2R1B -0.95 -15.16 -0.64 9.95e-40 Primary sclerosing cholangitis; CRC cis rs76419734 0.510 rs7659526 chr4:106621643 T/C cg24545054 chr4:106630052 GSTCD;INTS12 0.61 7.45 0.38 8.1e-13 Post bronchodilator FEV1; CRC cis rs11676348 0.846 rs7594532 chr2:219008000 T/C cg00012203 chr2:219082015 ARPC2 -0.45 -6.8 -0.35 4.82e-11 Ulcerative colitis; CRC trans rs4942242 0.512 rs9533552 chr13:44187194 C/T cg26741380 chr15:41871084 TYRO3 -0.49 -6.75 -0.35 6.74e-11 Response to tocilizumab in rheumatoid arthritis; CRC cis rs6988636 1.000 rs13259806 chr8:124190103 A/T cg27053337 chr8:124217698 FAM83A 0.43 6.59 0.34 1.74e-10 Urinary uromodulin levels; CRC cis rs7647973 0.710 rs2029591 chr3:49646981 C/T cg13072238 chr3:49761600 GMPPB 0.5 5.73 0.3 2.25e-8 Menarche (age at onset); CRC cis rs7781557 1.000 rs17474893 chr7:102480757 C/T cg18108683 chr7:102477205 FBXL13 -0.49 -6.18 -0.32 1.92e-9 Colorectal adenoma (advanced); CRC cis rs11123170 0.543 rs2863242 chr2:113989236 C/T cg12889195 chr2:113992843 PAX8;LOC440839;LOC654433 0.5 5.73 0.3 2.21e-8 Renal function-related traits (BUN); CRC cis rs637571 0.522 rs1151512 chr11:65757533 G/A cg26695010 chr11:65641043 EFEMP2 -0.39 -5.99 -0.31 5.64e-9 Eosinophil percentage of white cells; CRC cis rs875971 0.862 rs6978028 chr7:65886300 G/C cg11764359 chr7:65958608 NA 0.57 8.44 0.42 1.01e-15 Aortic root size; CRC cis rs9457247 0.508 rs9459874 chr6:167504127 A/G cg07741184 chr6:167504864 NA -0.37 -6.68 -0.35 1.04e-10 Crohn's disease; CRC cis rs889312 0.500 rs1867731 chr5:56132115 C/G cg20203395 chr5:56204925 C5orf35 -0.41 -5.79 -0.3 1.68e-8 Breast cancer;Breast cancer (early onset); CRC trans rs2727020 0.675 rs1684258 chr11:49340020 G/A cg11707556 chr5:10655725 ANKRD33B 0.44 6.78 0.35 5.47e-11 Coronary artery disease; CRC cis rs514406 0.798 rs4351588 chr1:53263826 A/T cg25767906 chr1:53392781 SCP2 0.5 8.15 0.41 7.81e-15 Monocyte count; CRC cis rs10262624 0.504 rs4722255 chr7:23746072 G/T cg20363699 chr7:23626180 CLK2P -0.34 -6.06 -0.32 3.75e-9 Schizophrenia; CRC cis rs896854 0.714 rs6471503 chr8:95990283 G/A cg13393036 chr8:95962371 TP53INP1 -0.52 -8.9 -0.44 3.75e-17 Type 2 diabetes; CRC cis rs875971 0.862 rs12698526 chr7:65969105 T/C cg18876405 chr7:65276391 NA 0.51 8.19 0.41 5.69e-15 Aortic root size; CRC cis rs13064411 0.696 rs6773497 chr3:113186514 T/C cg18753928 chr3:113234510 CCDC52 -0.68 -10.59 -0.5 9.85e-23 Response to simvastatin treatment (PCSK9 protein level change); CRC cis rs9292777 0.720 rs56131636 chr5:40397378 C/T cg09067459 chr5:40385259 NA -0.55 -8.97 -0.44 2.31e-17 Crohn's disease;Multiple sclerosis; CRC cis rs9733 0.519 rs11807450 chr1:150677719 C/T cg18016565 chr1:150552671 MCL1 0.48 6.98 0.36 1.63e-11 Tonsillectomy; CRC cis rs13256369 0.851 rs13271698 chr8:8567539 C/A cg18904891 chr8:8559673 CLDN23 0.53 7.02 0.36 1.29e-11 Obesity-related traits; CRC cis rs4975709 0.610 rs1531994 chr5:1859297 T/C cg20790798 chr5:1857306 NA -0.42 -6.27 -0.33 1.16e-9 Cardiovascular disease risk factors; CRC cis rs7312933 0.703 rs1059360 chr12:42554505 A/G cg19980929 chr12:42632907 YAF2 0.44 6.55 0.34 2.22e-10 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CRC cis rs7940866 0.874 rs7112616 chr11:130805334 T/C cg12179176 chr11:130786555 SNX19 0.6 8.83 0.44 6.37e-17 Schizophrenia; CRC trans rs1656966 1.000 rs1656966 chr3:186466252 C/T cg06790019 chr1:44435457 DPH2 0.39 6.03 0.32 4.35e-9 Myopia (pathological); CRC trans rs7615952 0.866 rs1976459 chr3:125647486 A/T cg02007433 chr3:129722099 NA -0.46 -6.28 -0.33 1.08e-9 Blood pressure (smoking interaction); CRC cis rs1878931 0.517 rs17685105 chr16:3413749 C/T cg26668626 chr16:3451006 ZNF174;ZNF434 -0.88 -14.1 -0.61 1.26e-35 Body mass index (adult); CRC cis rs561341 0.883 rs2074102 chr17:30228884 G/A cg23018236 chr17:30244563 NA -0.62 -7.78 -0.39 9.36e-14 Hip circumference adjusted for BMI; CRC cis rs2153535 0.580 rs2184583 chr6:8447808 A/G cg07606381 chr6:8435919 SLC35B3 0.68 10.85 0.51 1.22e-23 Motion sickness; CRC cis rs6860806 1.000 rs6860806 chr5:131640536 C/T cg20512303 chr5:131592959 PDLIM4 -0.3 -5.74 -0.3 2.2e-8 Breast cancer; CRC cis rs875971 0.928 rs6970357 chr7:65968878 T/C cg18912574 chr7:65842487 NCRNA00174 0.35 6.09 0.32 3.11e-9 Aortic root size; CRC cis rs9486715 0.838 rs9400034 chr6:96954566 C/T cg18709589 chr6:96969512 KIAA0776 0.49 7.2 0.37 4.09e-12 Headache; CRC cis rs12431939 0.948 rs12436364 chr14:51671320 T/C cg23942311 chr14:51606299 NA -0.53 -6.66 -0.34 1.18e-10 Cancer; CRC cis rs7811142 1.000 rs11761725 chr7:100039815 C/T cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.59 7.34 0.38 1.66e-12 Platelet count; CRC cis rs6121246 0.909 rs6058460 chr20:30363071 G/A cg13852791 chr20:30311386 BCL2L1 0.69 10.77 0.51 2.2e-23 Mean corpuscular hemoglobin; CRC cis rs7615952 0.641 rs12495947 chr3:125771698 C/T cg02772935 chr3:125709198 NA -0.49 -5.74 -0.3 2.11e-8 Blood pressure (smoking interaction); CRC trans rs4942242 0.640 rs17538959 chr13:44229911 T/G cg26741380 chr15:41871084 TYRO3 -0.49 -6.87 -0.35 3.18e-11 Response to tocilizumab in rheumatoid arthritis; CRC cis rs1950626 0.699 rs12896504 chr14:101467948 A/G cg02351406 chr14:101447389 SNORD114-20;SNORD114-21 -0.92 -15.19 -0.64 7.57e-40 Pelvic organ prolapse (moderate/severe); CRC cis rs911119 0.657 rs13039144 chr20:23633755 A/G cg16589663 chr20:23618590 CST3 0.59 7.24 0.37 3.1e-12 Chronic kidney disease; CRC cis rs9916302 0.904 rs600010 chr17:37433517 T/C cg03013999 chr17:37608204 MED1 0.48 7.39 0.38 1.25e-12 Glomerular filtration rate (creatinine); CRC cis rs4711336 0.935 rs3818525 chr6:33660779 A/G cg14003231 chr6:33640908 ITPR3 0.43 6.92 0.36 2.39e-11 Height; CRC cis rs6076065 0.723 rs6083088 chr20:23343793 G/T cg11657817 chr20:23433608 CST11 0.41 6.05 0.32 3.98e-9 Facial morphology (factor 15, philtrum width); CRC cis rs9326248 1.000 rs4938344 chr11:117003749 G/A cg10130564 chr11:117069849 TAGLN 0.33 5.97 0.31 5.99e-9 Blood protein levels; CRC cis rs8018808 0.935 rs963283 chr14:77901456 C/A cg20045696 chr14:77926864 AHSA1 0.36 5.61 0.3 4.24e-8 Myeloid white cell count; CRC cis rs11608355 0.545 rs6606724 chr12:109905179 T/C cg05360138 chr12:110035743 NA 0.77 8.7 0.43 1.65e-16 Neuroticism; CRC cis rs911555 0.723 rs4906320 chr14:103876925 T/C cg12935359 chr14:103987150 CKB 0.57 9.22 0.45 3.63e-18 Intelligence (multi-trait analysis); CRC cis rs9393692 0.905 rs9358919 chr6:26287862 C/T cg00631329 chr6:26305371 NA -0.68 -13.3 -0.59 1.33e-32 Educational attainment; CRC cis rs875971 1.000 rs778696 chr7:65870813 C/G cg12463550 chr7:65579703 CRCP 0.48 6.96 0.36 1.89e-11 Aortic root size; CRC trans rs4942242 1.000 rs9533572 chr13:44234265 A/C cg19169023 chr15:41853346 TYRO3 -0.5 -7.39 -0.38 1.19e-12 Response to tocilizumab in rheumatoid arthritis; CRC cis rs191220855 1 rs191220855 chr2:200778130 A/G cg23649088 chr2:200775458 C2orf69 -0.63 -6.97 -0.36 1.79e-11 Chickenpox; CRC cis rs4692589 0.540 rs1904823 chr4:170956772 C/T cg19918862 chr4:170955249 NA 0.54 6.93 0.36 2.29e-11 Anxiety disorder; CRC cis rs9894429 0.934 rs35868252 chr17:79575472 C/G cg21984481 chr17:79567631 NPLOC4 0.53 9.8 0.48 4.52e-20 Eye color traits; CRC cis rs743757 1.000 rs2073496 chr3:50431142 A/G cg08207895 chr3:50388901 TUSC4;CYB561D2 0.44 6.52 0.34 2.64e-10 Diastolic blood pressure; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg00435006 chr16:1877199 HAGH;FAHD1 0.43 6.03 0.32 4.37e-9 Response to antipsychotic treatment; CRC cis rs6502050 0.835 rs7503225 chr17:80099639 C/A cg22110888 chr17:80059540 CCDC57 0.4 6.44 0.33 4.17e-10 Life satisfaction; CRC cis rs6963495 0.818 rs6961863 chr7:105180953 C/T cg13798780 chr7:105162888 PUS7 0.56 7.36 0.38 1.45e-12 Bipolar disorder (body mass index interaction); CRC cis rs7937682 0.883 rs631490 chr11:111452040 G/C cg19812747 chr11:111475976 SIK2 -0.57 -9.88 -0.48 2.42e-20 Primary sclerosing cholangitis; CRC cis rs2380220 0.606 rs9488080 chr6:96006973 A/G cg23517279 chr6:96025343 MANEA 0.47 5.65 0.3 3.57e-8 Behavioural disinhibition (generation interaction); CRC cis rs10504229 0.683 rs1495865 chr8:58141160 T/G cg05313129 chr8:58192883 C8orf71 -0.43 -6.11 -0.32 2.74e-9 Developmental language disorder (linguistic errors); CRC cis rs6952808 0.689 rs2008263 chr7:2048335 A/G cg22963979 chr7:1858916 MAD1L1 -0.47 -7.01 -0.36 1.39e-11 Bipolar disorder and schizophrenia; CRC cis rs644799 0.965 rs10831430 chr11:95509638 T/C cg03916912 chr11:95522834 CEP57;FAM76B 0.95 17.79 0.7 4.54e-50 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC trans rs79464052 0.571 rs75065885 chr5:140935085 T/C cg05255351 chr5:1503979 LPCAT1 -0.45 -6.07 -0.32 3.6e-9 Diffuse large B cell lymphoma; CRC cis rs7224737 1.000 rs1122326 chr17:40274873 A/C cg00647820 chr17:40259828 DHX58 -0.43 -5.71 -0.3 2.53e-8 Fibrinogen levels; CRC cis rs10461617 0.541 rs860581 chr5:56150537 A/G cg03609598 chr5:56110824 MAP3K1 -0.63 -6.01 -0.31 4.91e-9 Type 2 diabetes; CRC cis rs7945705 0.818 rs1988708 chr11:8882893 C/A cg21881798 chr11:8931708 C11orf17;ST5 -0.75 -12.86 -0.58 5.94e-31 Hemoglobin concentration; CRC cis rs28386778 0.897 rs2854208 chr17:61946885 C/T cg11494091 chr17:61959527 GH2 0.61 10.26 0.49 1.3e-21 Prudent dietary pattern; CRC cis rs4862750 0.872 rs9998173 chr4:187898778 T/A cg06074448 chr4:187884817 NA -0.6 -11.05 -0.52 2.44e-24 Lobe attachment (rater-scored or self-reported); CRC cis rs2739330 0.731 rs5751792 chr22:24401542 G/A cg04234412 chr22:24373322 LOC391322 -0.88 -16.78 -0.68 4.13e-46 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs4925325 0.955 rs1776262 chr20:60516023 G/T cg23262073 chr20:60523788 NA 0.59 9.4 0.46 9.75e-19 Obesity-related traits; CRC cis rs1008375 1.000 rs10011865 chr4:17645710 G/A cg02297831 chr4:17616191 MED28 0.44 5.83 0.31 1.29e-8 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs875971 0.660 rs10263935 chr7:66096028 A/G cg05627663 chr7:65219948 SNORA22;CCT6P1 0.42 6.22 0.32 1.49e-9 Aortic root size; CRC cis rs17270561 0.609 rs17267614 chr6:25730027 A/C cg17691542 chr6:26056736 HIST1H1C 0.72 8.98 0.44 2.16e-17 Iron status biomarkers; CRC cis rs9916302 0.904 rs8065879 chr17:37515978 G/A cg07936489 chr17:37558343 FBXL20 0.85 13.49 0.6 2.52e-33 Glomerular filtration rate (creatinine); CRC cis rs1218582 0.772 rs10908445 chr1:154849590 A/G cg06221963 chr1:154839813 KCNN3 0.82 17.08 0.69 2.73e-47 Prostate cancer; CRC cis rs9583531 0.891 rs61969076 chr13:111391568 C/T cg24331049 chr13:111365604 ING1 -0.55 -5.93 -0.31 7.6e-9 Coronary artery disease; CRC cis rs67478160 0.679 rs7156834 chr14:104211180 G/A cg01849466 chr14:104193079 ZFYVE21 -0.48 -8.4 -0.42 1.32e-15 Schizophrenia; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg15921587 chr2:73144353 EMX1 0.4 6.7 0.35 9.21e-11 Liver disease severity in Alagille syndrome; CRC cis rs6502050 0.835 rs9901076 chr17:80170020 G/A cg22110888 chr17:80059540 CCDC57 0.42 6.58 0.34 1.88e-10 Life satisfaction; CRC cis rs990171 1.000 rs4851575 chr2:103025203 G/A cg03938978 chr2:103052716 IL18RAP 0.45 5.81 0.3 1.49e-8 Lymphocyte counts; CRC cis rs7394190 0.630 rs78845904 chr10:75517249 C/A cg07699608 chr10:75541558 CHCHD1 0.6 6.34 0.33 7.42e-10 Incident atrial fibrillation; CRC cis rs763121 0.962 rs138703 chr22:39132748 C/T cg06022373 chr22:39101656 GTPBP1 0.72 11.06 0.52 2.15e-24 Menopause (age at onset); CRC cis rs1862618 0.853 rs832551 chr5:56180112 T/G cg20203395 chr5:56204925 C5orf35 -0.72 -8.29 -0.42 2.99e-15 Initial pursuit acceleration; CRC cis rs992157 0.835 rs4674282 chr2:219144230 A/T cg00012203 chr2:219082015 ARPC2 -0.47 -7.07 -0.36 9.21e-12 Colorectal cancer; CRC cis rs6961069 0.745 rs13233631 chr7:80270822 A/G cg04458919 chr7:80252533 CD36 0.35 6.19 0.32 1.76e-9 Platelet count; CRC cis rs9463078 0.683 rs227850 chr6:44699068 C/T cg25276700 chr6:44698697 NA 0.26 6.2 0.32 1.71e-9 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; CRC cis rs599083 0.530 rs2472415 chr11:68185616 T/C cg01657329 chr11:68192670 LRP5 0.49 6.94 0.36 2.03e-11 Bone mineral density (spine); CRC cis rs9399135 0.967 rs2150681 chr6:135375232 A/G cg22676075 chr6:135203613 NA -0.38 -5.76 -0.3 1.91e-8 Red blood cell count; CRC cis rs1801251 0.778 rs778340 chr2:233734083 C/T cg25237894 chr2:233734115 C2orf82 -0.63 -11.22 -0.53 6.04e-25 Coronary artery disease; CRC cis rs897984 0.806 rs11150600 chr16:30940331 C/T cg00531865 chr16:30841666 NA 0.49 6.96 0.36 1.84e-11 Dementia with Lewy bodies; CRC cis rs7586879 1.000 rs11683212 chr2:25120196 T/C cg04586622 chr2:25135609 ADCY3 -0.43 -7.19 -0.37 4.46e-12 Body mass index; CRC cis rs1348850 0.526 rs6433672 chr2:178378175 G/T cg27490568 chr2:178487706 NA 0.63 7.52 0.38 5.2e-13 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs3764400 0.567 rs1979897 chr17:46309546 C/T cg10706073 chr17:46328419 SKAP1 -0.61 -6.65 -0.34 1.23e-10 Body mass index; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg10040922 chr8:124778506 NA 0.39 6.13 0.32 2.49e-9 Liver disease severity in Alagille syndrome; CRC cis rs10071761 0.513 rs10462011 chr5:40372062 T/A cg09067459 chr5:40385259 NA -0.53 -7.11 -0.37 7.18e-12 Selective IgA deficiency; CRC cis rs2976388 0.556 rs4736300 chr8:143829269 C/T cg15511327 chr8:143859410 LYNX1 -0.39 -6.32 -0.33 8.3e-10 Urinary tract infection frequency; CRC cis rs6502050 0.835 rs11658335 chr17:80084821 C/T cg13198984 chr17:80129470 CCDC57 -0.48 -8.56 -0.43 4.49e-16 Life satisfaction; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg08146621 chr2:158453928 ACVR1C 0.31 6.01 0.31 4.97e-9 Liver disease severity in Alagille syndrome; CRC cis rs4969178 0.965 rs16971105 chr17:76393975 G/T cg20026190 chr17:76395443 PGS1 0.36 5.63 0.3 3.83e-8 HDL cholesterol levels; CRC cis rs600806 0.888 rs6695482 chr1:109870859 C/G cg23032129 chr1:109941072 SORT1 -0.28 -6.04 -0.32 4.16e-9 Intelligence (multi-trait analysis); CRC cis rs2411233 1.000 rs11070162 chr15:39270290 C/T cg23129342 chr15:39283510 NA 0.31 5.69 0.3 2.8e-8 Platelet count; CRC cis rs1005277 0.579 rs1740745 chr10:38520056 T/C cg03665457 chr10:38645376 HSD17B7P2 -0.42 -5.96 -0.31 6.58e-9 Extrinsic epigenetic age acceleration; CRC cis rs10504229 0.728 rs77197419 chr8:58150879 C/A cg02725872 chr8:58115012 NA -0.57 -9.07 -0.45 1.09e-17 Developmental language disorder (linguistic errors); CRC cis rs9467773 1.000 rs9461259 chr6:26504835 C/A cg09904177 chr6:26538194 HMGN4 0.85 14.75 0.63 3.95e-38 Intelligence (multi-trait analysis); CRC cis rs752010 0.645 rs1109254 chr1:42091770 T/C cg06885757 chr1:42089581 HIVEP3 0.66 10.99 0.52 3.83e-24 Lupus nephritis in systemic lupus erythematosus; CRC cis rs67311347 1.000 rs11714912 chr3:40494065 A/G cg09455208 chr3:40491958 NA -0.4 -8.17 -0.41 6.54e-15 Renal cell carcinoma; CRC cis rs1953600 0.837 rs2236556 chr10:81932790 T/C cg04850286 chr10:81895943 PLAC9 0.37 6.68 0.35 1.01e-10 Sarcoidosis; CRC cis rs2153535 0.580 rs7341381 chr6:8470537 A/G cg07606381 chr6:8435919 SLC35B3 0.67 10.79 0.51 1.94e-23 Motion sickness; CRC cis rs34779708 0.966 rs10827492 chr10:35429825 A/G cg03585969 chr10:35415529 CREM -0.55 -7.41 -0.38 1.08e-12 Inflammatory bowel disease;Crohn's disease; CRC cis rs13191362 1.000 rs13213408 chr6:162998049 A/T cg21926612 chr6:163149169 PACRG;PARK2 0.79 11.14 0.52 1.12e-24 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs17155006 0.702 rs399290 chr7:107725977 T/C cg05962710 chr7:107745446 LAMB4 -0.36 -5.82 -0.31 1.39e-8 Pneumococcal bacteremia; CRC cis rs990171 1.000 rs6753717 chr2:102993161 A/C cg03938978 chr2:103052716 IL18RAP 0.46 5.82 0.31 1.37e-8 Lymphocyte counts; CRC cis rs6089584 0.888 rs6061973 chr20:60610870 C/T cg18761221 chr20:60518478 NA 0.45 7.21 0.37 3.74e-12 Body mass index; CRC cis rs875971 0.825 rs59466412 chr7:65565358 A/G cg12463550 chr7:65579703 CRCP -0.53 -7.55 -0.38 4.32e-13 Aortic root size; CRC cis rs3772130 0.961 rs13072618 chr3:121391833 G/A cg20356878 chr3:121714668 ILDR1 0.5 7.56 0.38 4.08e-13 Cognitive performance; CRC cis rs11190604 1.000 rs2003284 chr10:102202338 A/G cg16342193 chr10:102329863 NA -0.37 -6.17 -0.32 2.02e-9 Palmitoleic acid (16:1n-7) levels; CRC cis rs13191362 0.935 rs73008456 chr6:163013697 G/A cg21926612 chr6:163149169 PACRG;PARK2 0.78 10.8 0.51 1.77e-23 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs317689 0.690 rs10878947 chr12:69642683 A/T cg14784868 chr12:69753453 YEATS4 0.46 5.81 0.31 1.44e-8 Response to diuretic therapy; CRC cis rs7777754 0.512 rs7785224 chr7:50562361 T/C cg18232548 chr7:50535776 DDC -0.46 -7.04 -0.36 1.12e-11 Response to zileuton treatment in asthma (FEV1 change interaction); CRC cis rs7208859 0.623 rs11652631 chr17:29060766 A/G cg13385521 chr17:29058706 SUZ12P 0.7 7.85 0.4 5.96e-14 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs4808199 0.894 rs9304960 chr19:19465529 G/A cg03709012 chr19:19516395 GATAD2A 0.96 11.1 0.52 1.55e-24 Nonalcoholic fatty liver disease; CRC cis rs7412746 0.658 rs11204739 chr1:150865760 A/G cg15448220 chr1:150897856 SETDB1 0.55 8.06 0.41 1.47e-14 Melanoma; CRC cis rs7953508 0.506 rs3782415 chr12:93967755 T/C cg18151635 chr12:93972918 NA -0.8 -11.67 -0.54 1.42e-26 Pubertal anthropometrics; CRC trans rs113835537 0.627 rs4630309 chr11:66333072 A/C cg25433682 chr16:30407049 ZNF48 0.6 6.37 0.33 6.55e-10 Airway imaging phenotypes; CRC cis rs7680126 0.500 rs4697933 chr4:10146493 G/A cg11266682 chr4:10021025 SLC2A9 -0.41 -6.12 -0.32 2.67e-9 Urate levels in lean individuals;Urate levels in overweight individuals;Urate levels in obese individuals; CRC cis rs1728785 1.000 rs4783657 chr16:68586322 G/T cg02972257 chr16:68554789 NA -0.6 -7.46 -0.38 7.85e-13 Ulcerative colitis; CRC cis rs1862618 0.671 rs252897 chr5:56223000 G/A cg24531977 chr5:56204891 C5orf35 -0.68 -10.3 -0.49 9.16e-22 Initial pursuit acceleration; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg03333267 chr4:6577084 MAN2B2 0.48 7.22 0.37 3.6e-12 Intelligence (multi-trait analysis); CRC cis rs9323205 0.773 rs4334206 chr14:51702414 G/C cg23942311 chr14:51606299 NA -0.52 -6.19 -0.32 1.82e-9 Cancer; CRC cis rs950169 0.840 rs4842853 chr15:84942304 G/T cg11189052 chr15:85197271 WDR73 0.63 8.8 0.44 7.65e-17 Schizophrenia; CRC cis rs34172651 0.617 rs9922436 chr16:24704490 C/G cg02428538 chr16:24856791 SLC5A11 -0.57 -6.94 -0.36 2.12e-11 Intelligence (multi-trait analysis); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg25880573 chr1:24073129 TCEB3 0.43 6.96 0.36 1.8e-11 Liver disease severity in Alagille syndrome; CRC trans rs877282 0.898 rs11253347 chr10:765769 A/G cg22713356 chr15:30763199 NA 1.3 15.02 0.64 3.32e-39 Uric acid levels; CRC cis rs10979 1.000 rs12191231 chr6:143891114 A/C cg25407410 chr6:143891975 LOC285740 -0.83 -13.58 -0.6 1.21e-33 Hypospadias; CRC cis rs4555082 0.874 rs2816621 chr14:105732762 A/T cg06808227 chr14:105710500 BRF1 -0.62 -8.84 -0.44 5.97e-17 Mean platelet volume;Platelet distribution width; CRC cis rs8062405 1.000 rs62036624 chr16:28839930 G/T cg16576597 chr16:28551801 NUPR1 0.48 6.89 0.35 2.93e-11 Cognitive ability (multi-trait analysis);Cognitive ability; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg20444381 chr8:109456000 TTC35 0.41 6.17 0.32 2.06e-9 Liver disease severity in Alagille syndrome; CRC cis rs10504229 0.512 rs77289815 chr8:57995242 A/G cg02725872 chr8:58115012 NA -0.56 -6.81 -0.35 4.53e-11 Developmental language disorder (linguistic errors); CRC cis rs9488822 0.651 rs3798228 chr6:116321156 T/C cg26893134 chr6:116381904 FRK 0.26 7.61 0.39 2.98e-13 Cholesterol, total;LDL cholesterol; CRC cis rs4713118 0.824 rs7759217 chr6:27730463 A/G cg15786705 chr6:28176104 NA 0.54 7.17 0.37 4.95e-12 Parkinson's disease; CRC cis rs853679 0.517 rs35512245 chr6:28079953 T/C cg03623178 chr6:28175578 NA 0.95 12.14 0.56 2.76e-28 Depression; CRC cis rs651907 0.557 rs3094296 chr3:101400167 A/G cg11279151 chr3:101281821 RG9MTD1 -0.52 -6.96 -0.36 1.89e-11 Colorectal cancer; CRC cis rs9786986 0.516 rs12401892 chr1:235701393 A/G cg08848088 chr1:235714526 GNG4 0.51 6.19 0.32 1.84e-9 Body mass index; CRC cis rs7113874 0.569 rs10769916 chr11:8598214 G/A cg20771178 chr11:8615675 STK33 -0.35 -5.73 -0.3 2.29e-8 Body mass index in physically active individuals;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs2072510 0.966 rs2660896 chr12:96423782 A/G cg09636302 chr12:96389483 HAL -0.37 -5.89 -0.31 9.58e-9 Metabolite levels (small molecules and protein measures); CRC cis rs7635838 0.684 rs2606757 chr3:11358163 T/A cg00170343 chr3:11313890 ATG7 0.47 7.32 0.37 1.86e-12 HDL cholesterol; CRC cis rs798554 0.757 rs1183085 chr7:2875570 G/A cg17321639 chr7:2759063 NA -0.54 -7.28 -0.37 2.52e-12 Height; CRC trans rs2303319 0.504 rs62189047 chr2:162613314 T/A cg10498984 chr16:28874827 SH2B1 -0.73 -6.3 -0.33 9.75e-10 Cognitive function; CRC cis rs55794721 0.509 rs7554255 chr1:25778106 C/T cg20684491 chr1:25596433 NA 0.45 7.96 0.4 2.75e-14 Plateletcrit;Mean corpuscular volume; CRC cis rs6460942 1.000 rs6944134 chr7:12418036 T/C cg20607287 chr7:12443886 VWDE -0.62 -7.08 -0.36 8.95e-12 Coronary artery disease; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg26595336 chr15:82338380 MEX3B 0.35 6.06 0.32 3.81e-9 Liver disease severity in Alagille syndrome; CRC cis rs847577 0.609 rs34320230 chr7:97785500 C/T cg21770322 chr7:97807741 LMTK2 0.87 19.48 0.73 9.87e-57 Breast cancer; CRC cis rs4713118 0.513 rs202908 chr6:28011551 C/G cg03623178 chr6:28175578 NA 0.77 11.47 0.53 7.75e-26 Parkinson's disease; CRC cis rs9894429 0.646 rs8079963 chr17:79603285 C/T cg13777783 chr17:79615861 NA -0.3 -5.61 -0.3 4.38e-8 Eye color traits; CRC cis rs7659604 0.539 rs56159666 chr4:122782879 G/A cg19748678 chr4:122722346 EXOSC9 0.65 10.2 0.49 2.12e-21 Type 2 diabetes; CRC cis rs7727544 0.904 rs58835386 chr5:131600559 A/G cg02033258 chr5:131593261 PDLIM4 0.34 6.62 0.34 1.48e-10 Blood metabolite levels; CRC cis rs6834538 0.538 rs4833412 chr4:113410427 C/T cg10021238 chr4:113569128 MIR367;LARP7 -0.36 -5.64 -0.3 3.76e-8 Free thyroxine concentration; CRC cis rs6459804 0.967 rs10233396 chr7:157512290 C/T cg03339717 chr7:157503488 PTPRN2 0.32 5.69 0.3 2.83e-8 Bipolar disorder and schizophrenia; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg20706316 chr1:8398600 SLC45A1 -0.4 -6.44 -0.33 4.33e-10 Liver disease severity in Alagille syndrome; CRC cis rs11122272 0.735 rs2808603 chr1:231537738 T/C cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.59 -8.85 -0.44 5.46e-17 Hemoglobin concentration; CRC cis rs12908161 0.959 rs17534709 chr15:85314397 G/C cg11189052 chr15:85197271 WDR73 0.59 8.23 0.41 4.55e-15 Schizophrenia; CRC cis rs523522 0.962 rs603574 chr12:120998443 A/G cg12219531 chr12:120966889 COQ5 0.69 9.18 0.45 4.98e-18 High light scatter reticulocyte count; CRC trans rs7395662 1.000 rs4882019 chr11:48598748 A/G cg21153622 chr11:89784906 NA -0.48 -7.74 -0.39 1.26e-13 HDL cholesterol; CRC cis rs2120019 0.938 rs59094290 chr15:75308561 G/T cg09165964 chr15:75287851 SCAMP5 -0.88 -13.56 -0.6 1.38e-33 Blood trace element (Zn levels); CRC cis rs10493773 1.000 rs3767163 chr1:86121895 T/G cg17807903 chr1:86174739 ZNHIT6 -0.48 -9.66 -0.47 1.37e-19 Urate levels in overweight individuals; CRC cis rs4713118 0.955 rs9468206 chr6:27690453 G/T cg20933634 chr6:27740509 NA 0.57 8.06 0.41 1.42e-14 Parkinson's disease; CRC cis rs12142240 0.698 rs17361812 chr1:46814008 C/T cg00530320 chr1:46809349 NSUN4 0.58 7.81 0.4 7.54e-14 Menopause (age at onset); CRC cis rs2346160 1.000 rs7753298 chr6:167664193 G/A cg04673565 chr6:167680447 NA 0.39 6.55 0.34 2.28e-10 Parental extreme longevity (95 years and older); CRC cis rs7703744 0.681 rs17145294 chr5:118701433 G/T cg17471836 chr5:118691007 TNFAIP8 0.44 6.08 0.32 3.4e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs10504229 1.000 rs58382845 chr8:58169851 A/C cg02725872 chr8:58115012 NA -0.37 -6.24 -0.33 1.33e-9 Developmental language disorder (linguistic errors); CRC cis rs449789 0.857 rs591953 chr6:159716746 G/A cg14500486 chr6:159655392 FNDC1 -0.48 -7.29 -0.37 2.38e-12 Pulse pressure; CRC cis rs17270561 0.541 rs12192932 chr6:25911502 A/G cg16482183 chr6:26056742 HIST1H1C 1.01 12.18 0.56 1.97e-28 Iron status biomarkers; CRC trans rs11098499 0.954 rs13145352 chr4:120409963 C/T cg25214090 chr10:38739885 LOC399744 -0.66 -10.48 -0.5 2.21e-22 Corneal astigmatism; CRC cis rs9916302 0.851 rs11078904 chr17:37650569 G/A cg03013999 chr17:37608204 MED1 0.45 6.92 0.36 2.36e-11 Glomerular filtration rate (creatinine); CRC cis rs9368481 0.678 rs62402024 chr6:26923976 T/C cg18278486 chr6:26987575 LOC100270746;C6orf41 0.42 6.69 0.35 9.55e-11 Autism spectrum disorder or schizophrenia; CRC cis rs9992667 0.955 rs6858772 chr4:38651003 T/C cg19726192 chr4:38663646 FLJ13197 -0.69 -8.97 -0.44 2.31e-17 Eosinophil percentage of granulocytes; CRC cis rs1005277 0.579 rs1740735 chr10:38497777 A/C cg25427524 chr10:38739819 LOC399744 -0.79 -14.55 -0.63 2.24e-37 Extrinsic epigenetic age acceleration; CRC cis rs72945132 0.714 rs72947077 chr11:70197431 A/G cg14191688 chr11:70257035 CTTN 0.48 6.17 0.32 2.02e-9 Coronary artery disease; CRC cis rs11650494 0.706 rs76778410 chr17:47459877 A/T cg08112188 chr17:47440006 ZNF652 1.03 8.96 0.44 2.43e-17 Prostate cancer; CRC trans rs3733585 0.673 rs6814664 chr4:9956228 C/T cg26043149 chr18:55253948 FECH -0.5 -7.65 -0.39 2.23e-13 Cleft plate (environmental tobacco smoke interaction); CRC trans rs34421088 0.623 rs2572433 chr8:11101041 C/T cg06636001 chr8:8085503 FLJ10661 0.5 6.92 0.36 2.41e-11 Neuroticism; CRC cis rs9326248 1.000 rs585849 chr11:117069061 A/G cg10398005 chr11:117014888 PAFAH1B2 -0.4 -5.7 -0.3 2.66e-8 Blood protein levels; CRC cis rs72945132 0.882 rs67283107 chr11:70221204 C/T cg14191688 chr11:70257035 CTTN 0.4 5.66 0.3 3.29e-8 Coronary artery disease; CRC cis rs611744 0.625 rs11779824 chr8:109278689 G/A cg21045802 chr8:109455806 TTC35 0.43 6.86 0.35 3.49e-11 Dupuytren's disease; CRC cis rs977987 0.778 rs4888400 chr16:75425596 G/C cg03315344 chr16:75512273 CHST6 0.54 9.02 0.45 1.64e-17 Dupuytren's disease; CRC cis rs736408 0.716 rs2239549 chr3:52823126 C/T cg10802521 chr3:52805072 NEK4 -0.52 -7.58 -0.39 3.44e-13 Bipolar disorder; CRC cis rs1552244 1.000 rs67852463 chr3:10157205 G/C cg18598329 chr3:10140678 FANCD2;C3orf24 -0.88 -11.47 -0.53 7.42e-26 Alzheimer's disease; CRC cis rs7647973 0.593 rs59684465 chr3:49874246 C/T cg13072238 chr3:49761600 GMPPB 0.51 5.82 0.31 1.41e-8 Menarche (age at onset); CRC cis rs7953508 0.659 rs1316739 chr12:93968256 G/A cg18151635 chr12:93972918 NA -0.68 -10.25 -0.49 1.39e-21 Pubertal anthropometrics; CRC cis rs10911251 0.546 rs10911260 chr1:183106230 A/C ch.1.3577855R chr1:183094577 LAMC1 -0.82 -14.2 -0.62 4.84e-36 Colorectal cancer; CRC cis rs977987 0.806 rs4887818 chr16:75361995 T/C cg03315344 chr16:75512273 CHST6 0.52 8.76 0.44 1.01e-16 Dupuytren's disease; CRC cis rs1559088 0.895 rs13345542 chr19:33586739 G/C cg27124370 chr19:33622961 WDR88 0.45 6.31 0.33 9.08e-10 Bone ultrasound measurement (broadband ultrasound attenuation); CRC cis rs9527 0.525 rs12770034 chr10:104635595 A/G cg08772003 chr10:104629869 AS3MT -0.35 -5.8 -0.3 1.53e-8 Arsenic metabolism; CRC cis rs853679 0.517 rs6932109 chr6:28078303 A/G cg06470822 chr6:28175283 NA -1.0 -14.15 -0.62 7.84e-36 Depression; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg08080475 chr2:110962626 NPHP1 0.46 6.45 0.34 3.99e-10 Thyroid stimulating hormone; CRC trans rs2172802 0.659 rs2343251 chr4:62492671 C/A cg01233948 chr15:31318495 TRPM1 0.43 6.01 0.31 4.87e-9 Partial epilepsies; CRC cis rs7119 0.651 rs12909292 chr15:77837982 G/T cg27398640 chr15:77910606 LINGO1 -0.38 -6.22 -0.32 1.53e-9 Type 2 diabetes; CRC cis rs4957048 0.577 rs56294732 chr5:568144 T/C cg14541582 chr5:601475 NA -0.28 -5.87 -0.31 1.05e-8 Ulcerative colitis; CRC cis rs1580019 0.563 rs34201720 chr7:32568935 G/A cg06627557 chr7:32535165 LSM5;AVL9 0.96 18.16 0.71 1.53e-51 Cognitive ability; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg02316091 chr9:5628906 KIAA1432 0.43 6.15 0.32 2.25e-9 Response to antipsychotic treatment; CRC cis rs2882667 0.858 rs11744972 chr5:138428789 A/G cg04439458 chr5:138467593 SIL1 -0.35 -6.05 -0.32 3.85e-9 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs727563 0.520 rs132773 chr22:42031768 T/A cg06634786 chr22:41940651 POLR3H 0.56 6.3 0.33 9.81e-10 Crohn's disease;Inflammatory bowel disease; CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg10659575 chr11:102188233 BIRC3 -0.51 -6.28 -0.33 1.05e-9 Diisocyanate-induced asthma; CRC cis rs7429990 0.932 rs6442101 chr3:48130893 C/T cg11946769 chr3:48343235 NME6 -0.47 -5.98 -0.31 5.78e-9 Educational attainment (years of education); CRC cis rs2439831 0.618 rs8023508 chr15:44176103 C/T cg02155558 chr15:43621948 ADAL;LCMT2 -0.56 -6.57 -0.34 1.96e-10 Lung cancer in ever smokers; CRC cis rs7647973 0.826 rs9834535 chr3:49378797 A/T cg07636037 chr3:49044803 WDR6 0.59 6.95 0.36 1.92e-11 Menarche (age at onset); CRC cis rs7927592 0.956 rs11228269 chr11:68289796 A/G cg01657329 chr11:68192670 LRP5 -0.48 -6.93 -0.36 2.18e-11 Total body bone mineral density; CRC cis rs7591163 0.959 rs10933217 chr2:228716226 T/C cg22079747 chr2:228736145 WDR69 -0.44 -5.94 -0.31 7.4e-9 Blood pressure; CRC trans rs17685 0.664 rs9801113 chr7:75792031 C/T cg19862616 chr7:65841803 NCRNA00174 0.97 16.87 0.68 1.91e-46 Coffee consumption;Coffee consumption (cups per day); CRC cis rs6089584 0.507 rs28545731 chr20:60634102 C/T cg06108461 chr20:60628389 TAF4 -0.77 -12.6 -0.57 5.74e-30 Body mass index; CRC cis rs1008375 1.000 rs2315556 chr4:17670861 T/C cg04450456 chr4:17643702 FAM184B 0.4 6.34 0.33 7.51e-10 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs2836974 0.965 rs2836967 chr21:40639102 T/G cg11890956 chr21:40555474 PSMG1 1.11 19.14 0.73 2.01e-55 Cognitive function; CRC trans rs11039798 0.588 rs10437592 chr11:48598859 G/T cg15704280 chr7:45808275 SEPT13 0.66 6.99 0.36 1.58e-11 Axial length; CRC cis rs6519955 0.897 rs4073601 chr22:46434686 A/G cg05468064 chr22:46423449 NA 0.44 8.75 0.43 1.14e-16 Dupuytren's disease; CRC cis rs270601 0.913 rs273916 chr5:131659830 C/A cg20512303 chr5:131592959 PDLIM4 0.42 7.16 0.37 5.31e-12 Acylcarnitine levels; CRC cis rs4900538 0.855 rs1209151 chr14:102893756 C/T cg18135206 chr14:102964638 TECPR2 -0.95 -16.91 -0.68 1.3e-46 Mean corpuscular volume;Mean corpuscular hemoglobin; CRC cis rs9494142 0.592 rs1547247 chr6:135390836 C/T cg24558204 chr6:135376177 HBS1L 0.53 7.04 0.36 1.16e-11 Lymphocyte counts;Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs2197308 0.765 rs11182481 chr12:37926019 T/C cg26384229 chr12:38710491 ALG10B 0.65 8.91 0.44 3.5e-17 Morning vs. evening chronotype; CRC cis rs1448094 0.967 rs10047659 chr12:86338278 C/A cg19622623 chr12:86230825 RASSF9 -0.36 -5.94 -0.31 7.17e-9 Major depressive disorder; CRC cis rs1707322 0.686 rs3014239 chr1:46089801 G/A cg06784218 chr1:46089804 CCDC17 -0.67 -12.22 -0.56 1.45e-28 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs9814567 1.000 rs6769885 chr3:134286913 G/C cg06109529 chr3:134205091 CEP63;ANAPC13 -0.83 -12.34 -0.56 5.38e-29 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs4919694 1.000 rs12257935 chr10:104803062 C/A cg04362960 chr10:104952993 NT5C2 1.11 10.44 0.5 3.09e-22 Arsenic metabolism; CRC cis rs4731207 0.591 rs28634794 chr7:124614430 A/G cg23710748 chr7:124431027 NA -0.39 -6.25 -0.33 1.29e-9 Cutaneous malignant melanoma; CRC cis rs2625529 0.617 rs2306576 chr15:72170686 C/T cg16672083 chr15:72433130 SENP8 0.45 7.02 0.36 1.26e-11 Red blood cell count; CRC cis rs9435341 0.965 rs1730862 chr1:107614003 G/A cg09367891 chr1:107599246 PRMT6 -0.69 -10.35 -0.5 6.19e-22 Facial morphology (factor 21, depth of nasal alae); CRC cis rs4319547 1.000 rs1392236 chr12:123074890 C/G cg23029597 chr12:123009494 RSRC2 -0.63 -7.97 -0.4 2.6e-14 Body mass index; CRC cis rs10489202 0.683 rs2294817 chr1:168073601 C/A cg24449463 chr1:168025552 DCAF6 -0.5 -6.97 -0.36 1.74e-11 Schizophrenia; CRC cis rs514406 0.584 rs12095247 chr1:53193796 A/C cg25767906 chr1:53392781 SCP2 0.43 6.8 0.35 4.85e-11 Monocyte count; CRC cis rs3096299 0.667 rs2965947 chr16:89518670 T/C cg01788221 chr16:89496183 ANKRD11 -0.4 -5.97 -0.31 6.07e-9 Multiple myeloma (IgH translocation); CRC cis rs6951245 1.000 rs78896566 chr7:1080182 C/G cg26224354 chr7:1096374 C7orf50;GPR146 -0.89 -11.19 -0.53 7.61e-25 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs1862618 0.713 rs832550 chr5:56182589 C/T cg03609598 chr5:56110824 MAP3K1 -0.85 -10.06 -0.49 6.18e-21 Initial pursuit acceleration; CRC trans rs2797160 1.000 rs1418948 chr6:126007018 C/T cg05039488 chr6:79577232 IRAK1BP1 0.49 7.2 0.37 4.18e-12 Endometrial cancer; CRC cis rs1190552 0.739 rs1998421 chr14:102979644 C/T cg18135206 chr14:102964638 TECPR2 0.48 5.84 0.31 1.24e-8 Blood protein levels; CRC cis rs72945132 0.882 rs12278125 chr11:70134016 T/C cg00319359 chr11:70116639 PPFIA1 0.67 7.4 0.38 1.13e-12 Coronary artery disease; CRC cis rs9311676 0.656 rs6800514 chr3:58358717 C/T cg06643156 chr3:58380774 PXK 0.45 6.88 0.35 3.09e-11 Systemic lupus erythematosus; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg09906747 chr21:34914446 SON;GART 0.4 6.23 0.32 1.46e-9 Liver disease severity in Alagille syndrome; CRC cis rs2346177 0.806 rs56048837 chr2:46656647 G/C cg26688816 chr2:46740690 ATP6V1E2 -0.54 -7.96 -0.4 2.89e-14 HDL cholesterol; CRC cis rs7408868 0.563 rs10404382 chr19:15301389 C/A cg14696996 chr19:15285081 NOTCH3 0.71 7.4 0.38 1.15e-12 Pulse pressure; CRC trans rs3942852 0.774 rs10838811 chr11:48186795 A/G cg15704280 chr7:45808275 SEPT13 -0.74 -9.26 -0.45 2.76e-18 Acute lymphoblastic leukemia (childhood); CRC cis rs2991971 1.000 rs2934859 chr1:46017836 C/T cg24296786 chr1:45957014 TESK2 0.51 7.2 0.37 4.11e-12 High light scatter reticulocyte count; CRC cis rs2153535 0.580 rs7767756 chr6:8453428 A/C cg07606381 chr6:8435919 SLC35B3 0.68 10.87 0.51 1.01e-23 Motion sickness; CRC cis rs801193 1.000 rs2707854 chr7:66212597 G/A cg00343986 chr7:65444356 GUSB 0.49 7.26 0.37 2.87e-12 Aortic root size; CRC cis rs6545883 0.524 rs811871 chr2:61577949 C/T cg10580144 chr2:61372316 C2orf74 -0.35 -7.72 -0.39 1.46e-13 Tuberculosis; CRC cis rs3750082 0.926 rs11762628 chr7:32926571 T/C cg05721444 chr7:32995514 FKBP9 0.42 5.98 0.31 5.97e-9 Glomerular filtration rate (creatinine); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg09938965 chr16:89557187 ANKRD11 0.36 6.08 0.32 3.28e-9 Liver disease severity in Alagille syndrome; CRC cis rs7312774 0.618 rs35435903 chr12:107346572 G/C cg16260113 chr12:107380972 MTERFD3 0.79 8.09 0.41 1.18e-14 Severe influenza A (H1N1) infection; CRC cis rs7264396 0.635 rs2425166 chr20:34439391 G/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.59 -10.11 -0.49 4.17e-21 Total cholesterol levels; CRC cis rs11122272 0.732 rs999010 chr1:231495316 A/G cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.58 -8.87 -0.44 4.73e-17 Hemoglobin concentration; CRC cis rs910316 0.575 rs12889133 chr14:75465089 C/T cg03030879 chr14:75389066 RPS6KL1 -0.58 -8.54 -0.43 4.9e-16 Height; CRC cis rs12594515 1.000 rs8038320 chr15:45990267 G/C cg19682013 chr15:45996608 NA 0.32 6.7 0.35 9.09e-11 Waist circumference;Weight; CRC cis rs4713118 0.824 rs9468223 chr6:27740666 C/T cg02683197 chr6:28174875 NA 0.68 8.89 0.44 4.12e-17 Parkinson's disease; CRC cis rs7727544 0.548 rs4705938 chr5:131694077 A/G cg12564285 chr5:131593104 PDLIM4 0.37 6.74 0.35 7.11e-11 Blood metabolite levels; CRC cis rs2153535 0.580 rs2225766 chr6:8481833 G/A cg07606381 chr6:8435919 SLC35B3 0.67 10.9 0.52 8.07e-24 Motion sickness; CRC cis rs1799949 0.930 rs66499067 chr17:41248484 G/C cg25072359 chr17:41440525 NA 0.44 6.49 0.34 3.25e-10 Menopause (age at onset); CRC cis rs2050392 0.630 rs303426 chr10:30740379 A/G cg18806716 chr10:30721971 MAP3K8 0.46 6.65 0.34 1.25e-10 Inflammatory bowel disease; CRC cis rs11098499 0.954 rs878373 chr4:120237484 A/T cg24375607 chr4:120327624 NA 0.48 7.28 0.37 2.53e-12 Corneal astigmatism; CRC cis rs73206853 0.609 rs7966169 chr12:111045898 T/C cg12870014 chr12:110450643 ANKRD13A 0.8 9.13 0.45 7.15e-18 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC cis rs25422 0.887 rs9320666 chr6:118989181 C/T cg18833306 chr6:118973337 C6orf204 0.47 6.78 0.35 5.67e-11 Renal cell carcinoma; CRC cis rs9462027 1.000 rs6457792 chr6:34764443 C/T cg07306190 chr6:34760872 UHRF1BP1 0.34 5.6 0.3 4.49e-8 Systemic lupus erythematosus; CRC cis rs11098499 0.604 rs2389887 chr4:120570644 T/C cg09307838 chr4:120376055 NA 0.67 9.89 0.48 2.25e-20 Corneal astigmatism; CRC cis rs1997103 0.871 rs6956733 chr7:55393032 A/C cg17469321 chr7:55412551 NA 0.78 10.66 0.51 5.66e-23 QRS interval (sulfonylurea treatment interaction); CRC cis rs13108904 0.901 rs1316393 chr4:1315619 A/G cg05665937 chr4:1216051 CTBP1 -0.39 -5.73 -0.3 2.27e-8 Obesity-related traits; CRC cis rs916888 0.779 rs199498 chr17:44865603 A/G cg17911788 chr17:44343683 NA -0.52 -6.59 -0.34 1.77e-10 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs9916302 0.904 rs3964723 chr17:37403979 C/T cg03013999 chr17:37608204 MED1 0.45 6.63 0.34 1.35e-10 Glomerular filtration rate (creatinine); CRC cis rs7546094 0.967 rs1006298 chr1:113061959 G/C cg22162597 chr1:113214053 CAPZA1 0.41 5.66 0.3 3.23e-8 Platelet distribution width; CRC cis rs589448 0.967 rs2617834 chr12:69753365 T/C cg20891283 chr12:69753455 YEATS4 0.99 21.36 0.76 4.12e-64 Cerebrospinal fluid biomarker levels; CRC trans rs2303319 0.504 rs961421 chr2:162626099 G/C cg18122310 chr12:50236657 BCDIN3D -0.73 -6.35 -0.33 7.23e-10 Cognitive function; CRC cis rs7707921 0.767 rs178931 chr5:81575601 T/A cg07807695 chr5:81608485 ATP6AP1L -0.49 -7.76 -0.39 1.07e-13 Breast cancer; CRC cis rs9611519 0.808 rs5751074 chr22:41665722 G/A cg03806693 chr22:41940476 POLR3H -0.65 -8.94 -0.44 2.86e-17 Neuroticism; CRC cis rs5750830 0.649 rs4821893 chr22:39797779 G/A cg05872129 chr22:39784769 NA -0.59 -10.76 -0.51 2.43e-23 Intelligence (multi-trait analysis); CRC cis rs1862618 0.641 rs170733 chr5:56249251 A/G cg20203395 chr5:56204925 C5orf35 0.55 7.5 0.38 5.94e-13 Initial pursuit acceleration; CRC cis rs6743376 0.556 rs12475161 chr2:113823626 T/C cg09040174 chr2:113837401 NA 0.4 5.86 0.31 1.13e-8 Inflammatory biomarkers; CRC cis rs1448094 0.781 rs7959093 chr12:86335502 C/A cg18827107 chr12:86230957 RASSF9 -0.42 -6.7 -0.35 9.21e-11 Major depressive disorder; CRC cis rs1552244 0.882 rs17050672 chr3:10025463 G/A cg02579736 chr3:10068473 FANCD2;CIDECP 0.93 10.96 0.52 5.09e-24 Alzheimer's disease; CRC cis rs3858526 0.514 rs4595572 chr11:5864045 T/G cg13902645 chr11:5959945 NA -0.76 -12.94 -0.58 3.02e-31 DNA methylation (variation); CRC cis rs1878931 0.615 rs4786412 chr16:3440390 C/T cg26668626 chr16:3451006 ZNF174;ZNF434 0.98 17.23 0.69 7.26e-48 Body mass index (adult); CRC cis rs7208859 0.673 rs9891413 chr17:29208209 G/C cg13385521 chr17:29058706 SUZ12P 0.69 8.01 0.4 2.02e-14 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs7107174 1.000 rs2292572 chr11:78052864 G/T cg02023728 chr11:77925099 USP35 0.5 8.83 0.44 6.56e-17 Testicular germ cell tumor; CRC cis rs6460942 0.915 rs7802454 chr7:12454508 A/G cg06484146 chr7:12443880 VWDE -0.78 -8.1 -0.41 1.11e-14 Coronary artery disease; CRC cis rs847577 0.587 rs34307903 chr7:97728449 C/A cg24562669 chr7:97807699 LMTK2 0.78 17.5 0.69 6.1e-49 Breast cancer; CRC cis rs8103278 1.000 rs35302007 chr19:46219145 G/C cg20908204 chr19:46285434 DMPK -0.39 -7.76 -0.39 1.11e-13 Coronary artery disease; CRC cis rs60843830 1.000 rs9213 chr2:218386 G/A cg25945732 chr2:264204 ACP1;SH3YL1 0.72 11.61 0.54 2.45e-26 Spherical equivalent (joint analysis main effects and education interaction); CRC cis rs2576037 0.583 rs501882 chr18:44411066 A/T cg23996704 chr18:44553084 KATNAL2 -0.31 -6.05 -0.32 3.94e-9 Personality dimensions; CRC trans rs2303319 0.504 rs1567420 chr2:162475601 C/T cg18122310 chr12:50236657 BCDIN3D 0.71 6.0 0.31 5.07e-9 Cognitive function; CRC cis rs7666738 0.962 rs2865985 chr4:99068009 T/C cg17366294 chr4:99064904 C4orf37 0.46 7.3 0.37 2.22e-12 Colonoscopy-negative controls vs population controls; CRC cis rs1008375 0.933 rs10939757 chr4:17694125 T/C cg16339924 chr4:17578868 LAP3 0.47 6.4 0.33 5.38e-10 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs2944591 0.505 rs2592127 chr2:233791648 G/T cg11972305 chr2:233791962 NGEF -0.43 -6.83 -0.35 4.2e-11 Autism spectrum disorder or schizophrenia; CRC cis rs2075371 0.796 rs1646645 chr7:134012232 G/T cg20476274 chr7:133979776 SLC35B4 -0.67 -11.08 -0.52 1.79e-24 Mean platelet volume; CRC cis rs3018066 0.867 rs6819081 chr4:107132629 G/A cg01869342 chr4:106983673 TBCK -0.36 -5.61 -0.3 4.26e-8 Cancer; CRC cis rs6570726 0.791 rs6902404 chr6:145905254 G/A cg23711669 chr6:146136114 FBXO30 0.67 11.24 0.53 5.09e-25 Lobe attachment (rater-scored or self-reported); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg01202751 chr6:143248085 HIVEP2 0.47 6.68 0.35 1e-10 Response to antipsychotic treatment; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg04205485 chr20:32399084 CHMP4B 0.4 6.74 0.35 7.12e-11 Liver disease severity in Alagille syndrome; CRC cis rs1707322 1.000 rs11211205 chr1:46321874 C/T cg03146154 chr1:46216737 IPP 0.5 6.95 0.36 1.97e-11 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs477692 0.569 rs10764887 chr10:131321719 A/T cg05714579 chr10:131428358 MGMT 0.55 8.07 0.41 1.35e-14 Response to temozolomide; CRC cis rs2408955 0.522 rs3997 chr12:48481587 T/C cg00601486 chr12:48723148 H1FNT -0.35 -6.51 -0.34 2.89e-10 Glycated hemoglobin levels; CRC cis rs12630931 0.964 rs11710895 chr3:31980246 A/T cg21375017 chr3:31988082 OSBPL10 0.42 5.82 0.31 1.38e-8 Periodontal disease-related phenotypes; CRC cis rs524281 0.861 rs11227409 chr11:65870938 A/G cg16950941 chr11:66035639 RAB1B -0.6 -7.43 -0.38 9.41e-13 Electroencephalogram traits; CRC cis rs4862750 0.872 rs9997374 chr4:187877549 T/A cg03647317 chr4:187891568 NA -0.54 -10.22 -0.49 1.83e-21 Lobe attachment (rater-scored or self-reported); CRC trans rs7267979 0.833 rs4619688 chr20:25244101 C/G cg17903999 chr18:56338584 MALT1 -0.41 -6.49 -0.34 3.23e-10 Liver enzyme levels (alkaline phosphatase); CRC cis rs9902453 0.904 rs12952179 chr17:28412687 G/A cg26525008 chr17:28256777 EFCAB5;SSH2 -0.72 -12.03 -0.55 7.13e-28 Coffee consumption (cups per day); CRC cis rs12188164 0.686 rs72711367 chr5:418494 A/G cg16322479 chr5:444228 EXOC3;C5orf55 0.41 6.47 0.34 3.58e-10 Cystic fibrosis severity; CRC cis rs1448094 0.511 rs17345299 chr12:86166005 C/G cg00310523 chr12:86230176 RASSF9 0.38 6.1 0.32 3.01e-9 Major depressive disorder; CRC cis rs7131987 0.903 rs7302129 chr12:29415280 A/T cg09582351 chr12:29534625 ERGIC2 -0.34 -7.35 -0.38 1.53e-12 QT interval; CRC cis rs7264396 0.832 rs224378 chr20:34088764 G/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.42 -7.11 -0.36 7.49e-12 Total cholesterol levels; CRC cis rs9837602 1.000 rs62285462 chr3:99769834 T/A cg07805332 chr3:99536008 MIR548G;C3orf26 -0.48 -6.31 -0.33 8.91e-10 Breast cancer; CRC cis rs35306767 0.953 rs11253509 chr10:964306 C/T cg20503657 chr10:835505 NA 0.79 10.0 0.48 9.8e-21 Eosinophil percentage of granulocytes; CRC cis rs9527 0.590 rs7901197 chr10:104840433 C/T cg04362960 chr10:104952993 NT5C2 0.58 8.1 0.41 1.07e-14 Arsenic metabolism; CRC cis rs853679 0.550 rs6901017 chr6:28152583 T/C cg02683197 chr6:28174875 NA 0.9 11.93 0.55 1.69e-27 Depression; CRC cis rs3820068 0.581 rs56128111 chr1:15928948 T/G cg24675056 chr1:15929824 NA 0.49 6.77 0.35 5.87e-11 Systolic blood pressure; CRC cis rs9462027 0.628 rs4601124 chr6:34776910 A/C cg07306190 chr6:34760872 UHRF1BP1 -0.34 -5.95 -0.31 6.95e-9 Systemic lupus erythematosus; CRC trans rs6693295 0.605 rs4396095 chr1:246213270 A/G cg08881680 chr11:94965469 SESN3 0.49 6.02 0.31 4.7e-9 Migraine - clinic-based;Migraine with aura; CRC cis rs7849270 0.885 rs10760588 chr9:131877474 C/T cg13538475 chr9:131942899 NA -0.3 -6.04 -0.32 4.14e-9 Blood metabolite ratios; CRC cis rs4481887 0.741 rs28444488 chr1:248531776 C/A cg00666640 chr1:248458726 OR2T12 0.43 7.64 0.39 2.34e-13 Common traits (Other); CRC cis rs796364 0.789 rs176008 chr2:200814720 A/T cg25936922 chr2:200820526 C2orf60;C2orf47 0.7 7.64 0.39 2.33e-13 Schizophrenia; CRC cis rs6964587 0.934 rs2961019 chr7:91572749 T/G cg17063962 chr7:91808500 NA -0.73 -11.12 -0.52 1.29e-24 Breast cancer; CRC cis rs2742417 1.000 rs2742438 chr3:45743390 G/T cg04837898 chr3:45731254 SACM1L -0.36 -5.92 -0.31 7.98e-9 Response to anti-depressant treatment in major depressive disorder; CRC cis rs739401 0.595 rs6578305 chr11:3001120 C/T cg25174290 chr11:3078921 CARS 0.41 6.31 0.33 9.08e-10 Longevity; CRC cis rs2257205 0.667 rs6503879 chr17:56888183 T/A cg25885038 chr17:56607967 SEPT4 -0.53 -5.75 -0.3 2.07e-8 Pancreatic cancer; CRC cis rs9522267 0.535 rs7323829 chr13:112232308 C/G cg14352298 chr13:112236639 NA 0.3 6.71 0.35 8.5e-11 Hepatitis; CRC trans rs3733585 0.806 rs7375599 chr4:9954918 C/T cg26043149 chr18:55253948 FECH 0.52 8.06 0.41 1.46e-14 Cleft plate (environmental tobacco smoke interaction); CRC cis rs17376456 0.825 rs12716453 chr5:93271697 T/C cg21475434 chr5:93447410 FAM172A 0.83 8.23 0.41 4.37e-15 Diabetic retinopathy; CRC cis rs7811142 0.830 rs77861211 chr7:99962096 T/C cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.15 16.85 0.68 2.34e-46 Platelet count; CRC cis rs9916302 0.706 rs590051 chr17:37446571 T/C cg15445000 chr17:37608096 MED1 -0.33 -5.79 -0.3 1.62e-8 Glomerular filtration rate (creatinine); CRC cis rs4561483 0.831 rs2018199 chr16:11940968 C/T cg08843971 chr16:11963173 GSPT1 -0.58 -8.64 -0.43 2.51e-16 Testicular germ cell tumor; CRC cis rs7605827 0.930 rs1024870 chr2:15625846 T/C cg19274914 chr2:15703543 NA 0.39 6.05 0.32 3.96e-9 Educational attainment (years of education); CRC cis rs34172651 0.917 rs1075987 chr16:24794957 G/A cg06505273 chr16:24850292 NA 0.37 5.68 0.3 3.02e-8 Intelligence (multi-trait analysis); CRC trans rs1161463 0.834 rs1161458 chr13:29433372 A/G cg16311697 chr3:124249497 KALRN -0.45 -6.16 -0.32 2.11e-9 Attention deficit hyperactivity disorder symptoms (maternal expressed emotions interaction); CRC cis rs11190604 0.767 rs77838250 chr10:102180090 T/G cg07080220 chr10:102295463 HIF1AN 0.47 5.71 0.3 2.49e-8 Palmitoleic acid (16:1n-7) levels; CRC cis rs13118159 0.509 rs4974554 chr4:1356967 A/C cg19318889 chr4:1322082 MAEA 0.71 10.48 0.5 2.25e-22 Longevity; CRC cis rs4148883 0.675 rs10015824 chr4:100074544 C/G cg12011299 chr4:100065546 ADH4 0.5 10.96 0.52 4.83e-24 Alcohol dependence; CRC cis rs1005277 0.579 rs1548255 chr10:38417193 T/C cg25517755 chr10:38738941 LOC399744 -0.43 -6.22 -0.32 1.51e-9 Extrinsic epigenetic age acceleration; CRC cis rs4722166 0.630 rs2091115 chr7:22810166 G/T cg26061582 chr7:22766209 IL6 0.53 8.21 0.41 5.16e-15 Lung cancer; CRC cis rs11758351 0.660 rs11757754 chr6:26219744 A/C cg22723502 chr6:26240528 HIST1H4F -0.36 -5.85 -0.31 1.17e-8 Gout;Renal underexcretion gout; CRC cis rs10028773 0.666 rs12498657 chr4:120262866 G/C cg24375607 chr4:120327624 NA 0.49 7.84 0.4 6.14e-14 Educational attainment; CRC cis rs8180040 1.000 rs295461 chr3:47368010 T/C cg10298567 chr3:47292165 KIF9 -0.39 -6.59 -0.34 1.74e-10 Colorectal cancer; CRC cis rs12024301 0.557 rs16861259 chr1:183593328 A/G cg11505048 chr1:183622726 RGL1;APOBEC4 -0.69 -6.61 -0.34 1.56e-10 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs1448094 0.817 rs10779220 chr12:86323543 T/A cg00310523 chr12:86230176 RASSF9 0.43 7.26 0.37 2.88e-12 Major depressive disorder; CRC cis rs6952808 0.717 rs10950422 chr7:1926577 T/C cg21782813 chr7:2030301 MAD1L1 0.37 6.9 0.36 2.75e-11 Bipolar disorder and schizophrenia; CRC cis rs4803480 1.000 rs3745937 chr19:42071289 T/C cg08478046 chr19:42093086 CEACAM21 -0.34 -5.99 -0.31 5.44e-9 Schizophrenia; CRC cis rs11098499 0.954 rs13107475 chr4:120393011 A/T cg09307838 chr4:120376055 NA 0.72 11.22 0.53 5.84e-25 Corneal astigmatism; CRC cis rs7224685 0.501 rs781847 chr17:3958194 G/A cg09597638 chr17:3907349 NA 0.64 11.59 0.54 2.84e-26 Type 2 diabetes; CRC trans rs875971 0.597 rs11763224 chr7:65983615 G/T cg02869306 chr7:64672164 INTS4L1 -0.44 -6.32 -0.33 8.38e-10 Aortic root size; CRC cis rs9992667 0.829 rs337628 chr4:38635144 A/T cg19726192 chr4:38663646 FLJ13197 -0.43 -6.58 -0.34 1.83e-10 Eosinophil percentage of granulocytes; CRC cis rs4969178 0.560 rs4969182 chr17:76393030 T/C cg02319466 chr17:76381040 PGS1 0.39 6.09 0.32 3.12e-9 HDL cholesterol levels; CRC cis rs644799 0.965 rs2950522 chr11:95524719 C/T cg25478527 chr11:95522999 CEP57;FAM76B 0.52 7.78 0.39 9.35e-14 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs6502050 0.605 rs35158616 chr17:80094480 A/G cg02741985 chr17:80059408 CCDC57 0.41 6.66 0.34 1.17e-10 Life satisfaction; CRC cis rs6674176 0.628 rs2301993 chr1:44426025 G/A cg12908607 chr1:44402522 ARTN -0.51 -9.15 -0.45 6.35e-18 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Cognitive ability; CRC cis rs4919694 1.000 rs3740394 chr10:104634474 A/G cg04362960 chr10:104952993 NT5C2 1.12 9.9 0.48 2.22e-20 Arsenic metabolism; CRC cis rs6121246 0.821 rs6121209 chr20:30311258 G/C cg13852791 chr20:30311386 BCL2L1 0.69 11.36 0.53 1.87e-25 Mean corpuscular hemoglobin; CRC cis rs72772090 0.539 rs111237997 chr5:96114953 C/G cg17330273 chr5:96107758 CAST;ERAP1 -0.69 -6.38 -0.33 5.89e-10 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs6694672 1.000 rs7542397 chr1:197096720 G/A cg13682187 chr1:196946512 CFHR5 0.47 7.53 0.38 4.89e-13 Asthma; CRC cis rs4654899 1.000 rs6659152 chr1:21355841 C/G cg02927042 chr1:21476669 EIF4G3 -0.49 -7.89 -0.4 4.61e-14 Superior frontal gyrus grey matter volume; CRC cis rs847577 0.722 rs1013887 chr7:97709345 G/T cg21770322 chr7:97807741 LMTK2 0.8 17.97 0.7 8.5e-51 Breast cancer; CRC cis rs6951245 1.000 rs74887741 chr7:1110658 G/T cg21664854 chr7:1097933 C7orf50;GPR146 0.77 8.68 0.43 1.91e-16 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs2658782 1.000 rs2605582 chr11:93163799 C/T cg21115391 chr11:93143810 CCDC67 -0.39 -5.74 -0.3 2.17e-8 Pulmonary function decline; CRC cis rs9549367 0.713 rs9549356 chr13:113851633 A/G cg18105134 chr13:113819100 PROZ -0.88 -12.74 -0.57 1.69e-30 Platelet distribution width; CRC trans rs12714668 0.502 rs9833343 chr3:86822457 A/C cg13618939 chr10:46090486 MARCH8 -0.46 -6.07 -0.32 3.59e-9 Plasma omega-6 polyunsaturated fatty acid levels (arachidonic acid); CRC cis rs17376456 0.825 rs6874766 chr5:93213807 C/G cg25358565 chr5:93447407 FAM172A -1.07 -10.22 -0.49 1.71e-21 Diabetic retinopathy; CRC cis rs6500395 1.000 rs7201196 chr16:48674030 C/T cg04672837 chr16:48644449 N4BP1 0.45 6.67 0.35 1.09e-10 Response to tocilizumab in rheumatoid arthritis; CRC cis rs2976388 0.609 rs2717602 chr8:143805683 G/A cg04969067 chr8:143858791 LYNX1 0.45 7.71 0.39 1.5e-13 Urinary tract infection frequency; CRC cis rs8062405 1.000 rs4788101 chr16:28867804 C/T cg08761264 chr16:28874980 SH2B1 -0.44 -5.84 -0.31 1.27e-8 Cognitive ability (multi-trait analysis);Cognitive ability; CRC cis rs8005677 1.000 rs4982709 chr14:23394699 C/T cg01529538 chr14:23388837 RBM23 0.41 6.43 0.33 4.6e-10 Cognitive ability (multi-trait analysis); CRC cis rs4589502 0.800 rs1498499 chr15:67202620 C/T cg12317470 chr15:67143691 NA -0.52 -6.32 -0.33 8.32e-10 Lung cancer (smoking interaction); CRC cis rs9488822 0.651 rs3798228 chr6:116321156 T/C cg18764771 chr6:116381957 FRK 0.25 7.0 0.36 1.42e-11 Cholesterol, total;LDL cholesterol; CRC cis rs7264396 0.676 rs58372200 chr20:34555445 C/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.61 -9.83 -0.48 3.75e-20 Total cholesterol levels; CRC cis rs11031096 0.754 rs4910886 chr11:4143721 G/T cg18678763 chr11:4115507 RRM1 -0.43 -7.23 -0.37 3.35e-12 Mean corpuscular volume;Mean corpuscular hemoglobin; CRC cis rs929354 0.742 rs7807556 chr7:156934329 T/C cg17757837 chr7:157058334 UBE3C 0.71 11.72 0.54 9.78e-27 Body mass index; CRC cis rs9467603 0.925 rs6456701 chr6:25774130 C/T cg08501292 chr6:25962987 TRIM38 -0.98 -8.48 -0.42 7.8e-16 Intelligence (multi-trait analysis); CRC cis rs3091242 0.933 rs11802413 chr1:25760920 A/G cg27572855 chr1:25598939 RHD -0.36 -6.34 -0.33 7.43e-10 Erythrocyte sedimentation rate; CRC cis rs9905704 0.874 rs304265 chr17:56749298 C/T cg12560992 chr17:57184187 TRIM37 0.56 7.68 0.39 1.79e-13 Testicular germ cell tumor; CRC cis rs7772486 0.846 rs2144478 chr6:146381445 A/G cg13319975 chr6:146136371 FBXO30 -0.38 -5.84 -0.31 1.25e-8 Lobe attachment (rater-scored or self-reported); CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg22841110 chr11:64053472 BAD;GPR137 0.38 6.01 0.31 4.8e-9 Obesity-related traits; CRC cis rs17023223 0.537 rs2794313 chr1:119587440 T/C cg05756136 chr1:119680316 WARS2 -0.47 -6.29 -0.33 1.01e-9 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for BMI in active individuals; CRC cis rs8180040 0.620 rs2305635 chr3:47043622 G/A cg27129171 chr3:47204927 SETD2 -0.71 -11.16 -0.52 9.29e-25 Colorectal cancer; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg09735905 chr1:70820197 HHLA3;ANKRD13C 0.47 6.51 0.34 2.75e-10 Response to antipsychotic treatment; CRC cis rs9296092 0.500 rs9461885 chr6:33521069 G/T cg13560919 chr6:33536144 NA -0.43 -6.17 -0.32 2.04e-9 Age at smoking initiation in chronic obstructive pulmonary disease; CRC cis rs7493 0.853 rs2299266 chr7:95049073 A/G cg19678392 chr7:94953810 PON1 -0.59 -7.34 -0.38 1.65e-12 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs6951245 0.572 rs79489623 chr7:1045632 C/T cg24642844 chr7:1081250 C7orf50 -0.93 -7.82 -0.4 7.24e-14 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs13256369 0.802 rs12681326 chr8:8566389 G/A cg06636001 chr8:8085503 FLJ10661 0.47 5.88 0.31 1.02e-8 Obesity-related traits; CRC cis rs6860806 0.531 rs272888 chr5:131665423 T/C cg02033258 chr5:131593261 PDLIM4 0.37 6.32 0.33 8.71e-10 Breast cancer; CRC cis rs7552404 0.924 rs1251075 chr1:76190569 C/G cg03433033 chr1:76189801 ACADM 0.75 11.51 0.54 5.31e-26 Blood metabolite levels;Acylcarnitine levels; CRC trans rs2303319 0.504 rs62187657 chr2:162488091 G/A cg18122310 chr12:50236657 BCDIN3D -0.75 -6.09 -0.32 3.1e-9 Cognitive function; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg14878357 chr5:32174468 GOLPH3 0.43 6.01 0.31 4.84e-9 Anxiety disorder; CRC cis rs17213078 0.602 rs4851926 chr2:106742660 A/G cg15412446 chr2:106886593 NA 0.38 6.16 0.32 2.11e-9 Facial morphology (factor 23); CRC cis rs7103648 0.864 rs12801188 chr11:47388214 G/A cg20307385 chr11:47447363 PSMC3 0.92 14.89 0.63 1.13e-38 Diastolic blood pressure;Systolic blood pressure; CRC cis rs4713118 0.869 rs9461401 chr6:27703291 G/A cg03623178 chr6:28175578 NA 0.66 9.34 0.46 1.46e-18 Parkinson's disease; CRC cis rs3617 0.573 rs62253582 chr3:52928333 G/A cg07507251 chr3:52567010 NT5DC2 -0.4 -6.23 -0.32 1.42e-9 Red blood cell count;Autism spectrum disorder or schizophrenia; CRC cis rs853679 0.517 rs868987 chr6:28110148 A/G cg15786705 chr6:28176104 NA -0.77 -9.8 -0.48 4.72e-20 Depression; CRC cis rs8177253 0.507 rs4241357 chr3:133475563 A/C cg16262614 chr3:133464971 TF -0.38 -6.99 -0.36 1.51e-11 Iron status biomarkers; CRC cis rs9914988 0.887 rs62066838 chr17:27184533 C/T cg16670446 chr17:27188758 MIR451;MIR144 -0.61 -10.26 -0.49 1.34e-21 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC trans rs629535 0.911 rs490165 chr8:70014976 A/G cg21567404 chr3:27674614 NA -0.91 -15.53 -0.65 3.58e-41 Dupuytren's disease; CRC trans rs2303319 0.504 rs12469302 chr2:162433831 G/T cg09481857 chr22:21368659 P2RX6;MGC16703 -0.66 -6.14 -0.32 2.36e-9 Cognitive function; CRC cis rs12900413 0.673 rs35308090 chr15:90308026 G/T cg24249390 chr15:90295951 MESP1 -0.59 -9.23 -0.45 3.35e-18 Coronary artery aneurysm in Kawasaki disease; CRC cis rs72781680 0.582 rs72783611 chr2:24291445 C/T cg20701182 chr2:24300061 SF3B14 0.62 7.39 0.38 1.26e-12 Lymphocyte counts; CRC trans rs35110281 0.627 rs6518268 chr21:44967448 A/G cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.47 7.69 0.39 1.73e-13 Mean corpuscular volume; CRC cis rs9303401 0.734 rs8073316 chr17:57211381 A/T cg02118635 chr17:56770003 RAD51C;TEX14 -0.49 -7.27 -0.37 2.6e-12 Cognitive test performance; CRC trans rs877282 0.838 rs11253374 chr10:774961 C/T cg22713356 chr15:30763199 NA 1.28 16.63 0.68 1.75e-45 Uric acid levels; CRC cis rs748404 0.560 rs570933 chr15:43824030 A/G cg02155558 chr15:43621948 ADAL;LCMT2 0.52 7.52 0.38 5.41e-13 Lung cancer; CRC trans rs7618501 0.966 rs2352974 chr3:49890613 C/T cg21582582 chr3:182698605 DCUN1D1 0.54 7.95 0.4 3.05e-14 Intelligence (multi-trait analysis); CRC cis rs1448094 1.000 rs7305284 chr12:86343786 C/T cg02569458 chr12:86230093 RASSF9 0.39 6.7 0.35 9.15e-11 Major depressive disorder; CRC cis rs8060686 0.858 rs8051587 chr16:67796315 A/C cg00318322 chr16:67708822 GFOD2 -0.31 -5.68 -0.3 3.01e-8 HDL cholesterol;Metabolic syndrome; CRC cis rs17713451 0.593 rs17715595 chr7:151272490 C/T cg18404559 chr7:151322523 PRKAG2 -0.54 -6.33 -0.33 7.94e-10 Interleukin-4 levels; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg22640452 chr17:38256967 NR1D1 0.45 6.28 0.33 1.09e-9 Response to antipsychotic treatment; CRC cis rs929354 0.742 rs7806775 chr7:156947199 A/G cg05182265 chr7:156933206 UBE3C -0.76 -14.38 -0.62 1.04e-36 Body mass index; CRC cis rs10782582 0.609 rs72979226 chr1:76302222 C/A cg10523679 chr1:76189770 ACADM -0.41 -5.81 -0.31 1.47e-8 Daytime sleep phenotypes; CRC cis rs12451471 0.667 rs12942002 chr17:78101629 C/G cg18972013 chr17:78078605 GAA -0.4 -5.8 -0.3 1.58e-8 Plateletcrit;Mean corpuscular hemoglobin concentration; CRC cis rs6951245 1.000 rs78158942 chr7:1090440 G/T cg26224354 chr7:1096374 C7orf50;GPR146 -0.95 -12.04 -0.55 6.58e-28 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs9427116 0.502 rs9426830 chr1:154594690 A/G cg24304309 chr1:154577895 ADAR 0.34 5.69 0.3 2.87e-8 Blood protein levels; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg06824134 chr2:45878977 PRKCE 0.44 6.06 0.32 3.81e-9 Response to antipsychotic treatment; CRC cis rs10504229 0.683 rs113492050 chr8:58130046 A/G cg22535103 chr8:58192502 C8orf71 -0.7 -9.34 -0.46 1.47e-18 Developmental language disorder (linguistic errors); CRC cis rs919433 0.927 rs13032495 chr2:198189346 C/T cg03934865 chr2:198174659 NA -0.4 -6.26 -0.33 1.2e-9 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC cis rs9322193 0.923 rs1984111 chr6:150152856 G/A cg04369109 chr6:150039330 LATS1 -0.42 -5.69 -0.3 2.75e-8 Lung cancer; CRC cis rs780096 0.546 rs1528533 chr2:27595756 G/C cg17158414 chr2:27665306 KRTCAP3 -0.29 -6.32 -0.33 8.55e-10 Total body bone mineral density; CRC cis rs4819052 0.851 rs7275870 chr21:46671214 C/T cg11663144 chr21:46675770 NA -0.86 -15.13 -0.64 1.24e-39 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs60871478 1.000 rs4720917 chr7:806998 C/G cg04727924 chr7:799746 HEATR2 -0.45 -6.79 -0.35 5.27e-11 Cerebrospinal P-tau181p levels; CRC cis rs9467773 1.000 rs2255070 chr6:26501777 C/G cg09904177 chr6:26538194 HMGN4 0.85 14.38 0.62 1.05e-36 Intelligence (multi-trait analysis); CRC cis rs1355223 0.902 rs34751755 chr11:34694243 C/T cg11058730 chr11:34937778 PDHX;APIP -0.42 -5.67 -0.3 3.17e-8 Systemic lupus erythematosus and Systemic sclerosis; CRC trans rs12478296 0.818 rs57194240 chr2:243011545 A/G cg06834434 chr14:75079333 LTBP2 0.56 6.98 0.36 1.64e-11 Obesity-related traits; CRC cis rs4766646 0.619 rs4766638 chr12:110298858 T/C cg01252219 chr12:110302105 GLTP 0.41 6.26 0.33 1.17e-9 Metabolite levels (MHPG); CRC cis rs853679 0.723 rs1736904 chr6:28219270 G/A cg21251018 chr6:28226885 NKAPL 0.44 5.64 0.3 3.75e-8 Depression; CRC cis rs10905065 0.965 rs2797488 chr10:5784509 C/T cg11519256 chr10:5708881 ASB13 0.43 6.16 0.32 2.15e-9 Menopause (age at onset); CRC cis rs873946 0.564 rs12772704 chr10:134557318 G/A cg06453172 chr10:134556979 INPP5A -0.67 -7.85 -0.4 6.07e-14 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CRC cis rs9467773 1.000 rs6933176 chr6:26540178 G/A cg09904177 chr6:26538194 HMGN4 0.86 14.87 0.63 1.27e-38 Intelligence (multi-trait analysis); CRC cis rs2404602 0.735 rs2436994 chr15:76801063 G/C cg23625390 chr15:77176239 SCAPER -0.78 -12.91 -0.58 3.86e-31 Blood metabolite levels; CRC cis rs11628318 0.515 rs12884619 chr14:103095724 C/A cg12046867 chr14:103022105 NA -0.44 -5.89 -0.31 9.38e-9 Platelet count; CRC cis rs1552244 1.000 rs28684871 chr3:10072635 C/A cg10729496 chr3:10149963 C3orf24 0.49 6.45 0.34 3.88e-10 Alzheimer's disease; CRC cis rs11785400 0.762 rs4401833 chr8:143739731 A/T cg24634471 chr8:143751801 JRK 0.48 6.51 0.34 2.81e-10 Schizophrenia; CRC cis rs2425143 1.000 rs6060591 chr20:34351476 T/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.48 -6.17 -0.32 1.97e-9 Blood protein levels; CRC cis rs1552172 0.887 rs2040086 chr1:145651876 C/A cg11743829 chr1:145714124 CD160 -0.42 -6.29 -0.33 1.04e-9 Breast cancer; CRC cis rs10504229 0.683 rs7000349 chr8:58114569 C/A cg24829409 chr8:58192753 C8orf71 -0.54 -7.88 -0.4 4.9e-14 Developmental language disorder (linguistic errors); CRC cis rs7811142 1.000 rs11763414 chr7:100016844 C/G cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.63 8.16 0.41 7.42e-15 Platelet count; CRC cis rs755249 0.508 rs12023553 chr1:39671492 C/A cg11070191 chr1:39582205 MACF1 0.36 5.71 0.3 2.58e-8 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs6754311 0.773 rs188680 chr2:136630989 A/G cg25344623 chr2:136566232 LCT 0.33 6.03 0.32 4.33e-9 Mosquito bite size; CRC cis rs1707322 0.721 rs12069121 chr1:46231984 G/A cg06784218 chr1:46089804 CCDC17 0.65 12.23 0.56 1.36e-28 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs853679 0.517 rs4711164 chr6:28115156 C/T cg18032046 chr6:28092343 ZSCAN16 -0.51 -5.93 -0.31 7.47e-9 Depression; CRC cis rs79387448 0.810 rs75218113 chr2:103239356 C/G cg09003973 chr2:102972529 NA 0.74 7.27 0.37 2.71e-12 Gut microbiota (bacterial taxa); CRC cis rs910187 0.678 rs3818012 chr20:45816594 G/A cg27589058 chr20:45804311 EYA2 -0.36 -6.99 -0.36 1.54e-11 Migraine; CRC trans rs10982213 0.830 rs2274163 chr9:117188714 C/T cg23237097 chr1:160278129 COPA 0.41 6.22 0.32 1.47e-9 Interleukin-6 levels; CRC cis rs7901135 0.924 rs4948547 chr10:60568514 C/A cg23799393 chr10:60588674 BICC1 0.36 5.62 0.3 4.12e-8 Morning vs. evening chronotype; CRC cis rs7666738 0.830 rs4699593 chr4:98980628 A/G cg17366294 chr4:99064904 C4orf37 0.43 7.33 0.37 1.76e-12 Colonoscopy-negative controls vs population controls; CRC trans rs7308116 0.546 rs17307888 chr12:108212639 A/G cg10318744 chr14:69282256 NA -0.41 -6.01 -0.31 4.89e-9 Pelvic organ prolapse (moderate/severe); CRC cis rs12701220 0.604 rs12702122 chr7:1149494 C/G cg00990874 chr7:1149470 C7orf50 -0.7 -9.21 -0.45 4e-18 Bronchopulmonary dysplasia; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg01159149 chr11:10830970 EIF4G2 0.44 6.09 0.32 3.23e-9 Response to antipsychotic treatment; CRC cis rs9488822 0.636 rs12201275 chr6:116314563 C/G cg26893134 chr6:116381904 FRK 0.26 7.61 0.39 2.95e-13 Cholesterol, total;LDL cholesterol; CRC cis rs9926296 0.533 rs7190823 chr16:89866043 A/G cg27121462 chr16:89883253 FANCA 0.6 9.93 0.48 1.76e-20 Vitiligo; CRC trans rs6951245 0.572 rs80133931 chr7:1027286 C/T cg13565492 chr6:43139072 SRF -0.86 -6.19 -0.32 1.79e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC trans rs2303319 0.504 rs62189055 chr2:162625749 C/A cg22922770 chr7:98923339 ARPC1A -0.69 -6.19 -0.32 1.77e-9 Cognitive function; CRC trans rs6703335 0.870 rs10803142 chr1:243598234 A/G cg08322149 chr10:46222875 FAM21C 0.47 6.68 0.35 1.02e-10 Schizophrenia;Schizophrenia, schizoaffective disorder or bipolar disorder; CRC cis rs4243830 0.737 rs6692747 chr1:6610049 C/T cg22792644 chr1:6614718 TAS1R1;NOL9 0.82 8.06 0.41 1.4e-14 Body mass index; CRC cis rs747650 0.504 rs7935346 chr11:47008379 A/G cg19486271 chr11:47235900 DDB2 -0.4 -5.97 -0.31 6.08e-9 Acne (severe); CRC cis rs736408 0.716 rs2300149 chr3:52822921 C/T cg07507251 chr3:52567010 NT5DC2 0.41 5.65 0.3 3.4e-8 Bipolar disorder; CRC trans rs7944735 0.938 rs59185955 chr11:47961566 G/C cg03929089 chr4:120376271 NA 0.56 6.49 0.34 3.14e-10 Intraocular pressure; CRC cis rs10504073 0.669 rs818560 chr8:50035417 C/T cg00325661 chr8:49890786 NA 0.46 8.23 0.41 4.37e-15 Blood metabolite ratios; CRC cis rs11009175 0.725 rs4934646 chr10:33296609 C/T cg00146027 chr10:33299147 NA -0.28 -5.76 -0.3 1.95e-8 Depression (quantitative trait); CRC cis rs10540 0.908 rs71487293 chr11:486414 G/A cg03934478 chr11:495069 RNH1 0.67 7.26 0.37 2.84e-12 Body mass index; CRC cis rs7605827 0.930 rs4668446 chr2:15516020 C/T cg19274914 chr2:15703543 NA 0.4 6.03 0.32 4.33e-9 Educational attainment (years of education); CRC cis rs7917772 0.604 rs10883756 chr10:104400112 T/C cg11453585 chr10:104263688 ACTR1A;SUFU -0.78 -12.39 -0.56 3.49e-29 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC cis rs7618915 0.547 rs10865973 chr3:52718154 A/T cg18404041 chr3:52824283 ITIH1 -0.44 -9.03 -0.45 1.49e-17 Bipolar disorder; CRC cis rs11628318 0.763 rs11623312 chr14:103022060 G/T cg23071808 chr14:103021642 NA -0.68 -8.76 -0.44 1.02e-16 Platelet count; CRC cis rs4808199 0.948 rs12982276 chr19:19459800 T/C cg26732615 chr19:19648335 CILP2;YJEFN3 0.45 5.84 0.31 1.28e-8 Nonalcoholic fatty liver disease; CRC cis rs904251 0.861 rs1757173 chr6:37486952 A/C cg01843034 chr6:37503916 NA -0.48 -8.8 -0.44 7.73e-17 Cognitive performance; CRC cis rs3749237 0.595 rs7637999 chr3:49535115 C/T cg07636037 chr3:49044803 WDR6 0.55 8.01 0.4 2.07e-14 Resting heart rate; CRC cis rs881375 0.967 rs876445 chr9:123677102 A/T cg14255062 chr9:123606675 PSMD5;LOC253039 0.42 6.11 0.32 2.86e-9 Rheumatoid arthritis; CRC cis rs2075371 0.931 rs1646697 chr7:133999930 G/A cg20476274 chr7:133979776 SLC35B4 0.79 14.13 0.61 9.31e-36 Mean platelet volume; CRC cis rs12134245 0.776 rs13447526 chr1:91983174 A/G cg25838465 chr1:92012736 NA 0.63 10.6 0.5 8.74e-23 Breast cancer; CRC cis rs6502050 0.634 rs11077973 chr17:80095191 C/T cg09264619 chr17:80180166 NA -0.34 -5.81 -0.3 1.5e-8 Life satisfaction; CRC cis rs7209700 0.708 rs2292865 chr17:45364722 C/T cg08085267 chr17:45401833 C17orf57 0.48 7.1 0.36 7.5e-12 IgG glycosylation; CRC cis rs9916302 0.629 rs9972882 chr17:37807698 A/C cg07936489 chr17:37558343 FBXL20 -0.52 -7.29 -0.37 2.35e-12 Glomerular filtration rate (creatinine); CRC trans rs2303319 0.504 rs62189047 chr2:162613314 T/A cg14875682 chr5:52083620 ITGA1;PELO -0.73 -6.16 -0.32 2.11e-9 Cognitive function; CRC cis rs875971 0.545 rs7783889 chr7:65748353 T/A cg03233332 chr7:66118400 NA -0.44 -6.23 -0.32 1.46e-9 Aortic root size; CRC cis rs2204008 0.777 rs114096617 chr12:38342557 A/C cg13010199 chr12:38710504 ALG10B 0.47 6.28 0.33 1.09e-9 Bladder cancer; CRC cis rs10876993 0.672 rs2640611 chr12:58037757 T/A cg15848620 chr12:58087721 OS9 -0.61 -8.31 -0.42 2.52e-15 Celiac disease or Rheumatoid arthritis; CRC cis rs11098499 0.954 rs7656252 chr4:120404268 T/C cg09307838 chr4:120376055 NA 0.7 10.94 0.52 5.84e-24 Corneal astigmatism; CRC cis rs780096 0.546 rs1060525 chr2:27635582 A/G cg17158414 chr2:27665306 KRTCAP3 -0.27 -5.95 -0.31 6.92e-9 Total body bone mineral density; CRC cis rs9311474 0.629 rs7636227 chr3:52566682 G/A cg07507251 chr3:52567010 NT5DC2 0.52 8.43 0.42 1.1e-15 Electroencephalogram traits; CRC cis rs863345 0.967 rs12133354 chr1:158526537 T/C cg12129480 chr1:158549410 OR10X1 -0.26 -5.73 -0.3 2.21e-8 Pneumococcal bacteremia; CRC trans rs948562 0.895 rs11229537 chr11:58352865 T/C cg26660744 chr1:1573181 CDK11B 0.53 6.19 0.32 1.83e-9 Lymphoma; CRC cis rs9584850 0.574 rs17471079 chr13:99168721 C/T cg20487152 chr13:99095054 FARP1 0.48 6.12 0.32 2.67e-9 Neuroticism; CRC cis rs10771431 0.597 rs7976807 chr12:9352459 G/A cg08997352 chr12:9597637 DDX12 -0.45 -6.62 -0.34 1.43e-10 Breast size; CRC cis rs10883723 0.810 rs2296589 chr10:104248106 T/A cg11453585 chr10:104263688 ACTR1A;SUFU 0.92 17.46 0.69 8.98e-49 Allergic disease (asthma, hay fever or eczema); CRC cis rs951366 0.617 rs823080 chr1:205789282 G/A cg07167872 chr1:205819463 PM20D1 0.99 18.05 0.71 4.29e-51 Menarche (age at onset); CRC trans rs11098499 0.754 rs7672594 chr4:120248543 A/C cg25214090 chr10:38739885 LOC399744 0.53 8.36 0.42 1.78e-15 Corneal astigmatism; CRC cis rs6546324 0.625 rs2902025 chr2:67842424 A/G cg15745817 chr2:67799979 NA -0.56 -9.54 -0.47 3.44e-19 Endometriosis; CRC cis rs16975963 0.644 rs73031309 chr19:38031984 C/T cg15135657 chr19:38346511 NA -0.46 -6.32 -0.33 8.53e-10 Longevity; CRC cis rs4974559 0.947 rs58750335 chr4:1364764 G/A cg00684032 chr4:1343700 KIAA1530 -0.58 -5.61 -0.3 4.35e-8 Systolic blood pressure; CRC cis rs1568889 0.838 rs10835283 chr11:28214985 G/A cg06544937 chr11:28130018 METT5D1;KIF18A 0.91 15.16 0.64 9.43e-40 Bipolar disorder; CRC cis rs1005277 0.522 rs9418276 chr10:37940116 G/T cg25427524 chr10:38739819 LOC399744 -0.73 -12.15 -0.56 2.59e-28 Extrinsic epigenetic age acceleration; CRC cis rs8180040 0.900 rs4858894 chr3:47484953 C/G cg02527881 chr3:46936655 PTH1R -0.41 -7.83 -0.4 6.74e-14 Colorectal cancer; CRC cis rs35264875 0.898 rs72928701 chr11:68861564 C/T cg01993067 chr11:68851601 TPCN2 0.58 6.66 0.34 1.13e-10 Blond vs. brown hair color; CRC cis rs10504229 0.728 rs72650853 chr8:58151473 G/A cg08219700 chr8:58056026 NA 0.45 5.74 0.3 2.11e-8 Developmental language disorder (linguistic errors); CRC cis rs910316 1.000 rs12435391 chr14:75601737 A/G cg08847533 chr14:75593920 NEK9 0.92 17.18 0.69 1.12e-47 Height; CRC cis rs2243480 1.000 rs462853 chr7:65558167 G/C cg18252515 chr7:66147081 NA -1.14 -13.85 -0.61 1.06e-34 Diabetic kidney disease; CRC cis rs10751667 0.600 rs4076915 chr11:1012464 C/G cg23136738 chr11:925521 AP2A2 -0.38 -5.95 -0.31 6.73e-9 Alzheimer's disease (late onset); CRC trans rs34421088 0.560 rs1478898 chr8:11395079 G/A cg08975724 chr8:8085496 FLJ10661 -0.4 -6.01 -0.31 4.81e-9 Neuroticism; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg15344021 chr17:2240169 TSR1;SGSM2 0.45 6.31 0.33 9.14e-10 Response to antipsychotic treatment; CRC cis rs3096299 0.692 rs4785565 chr16:89515759 T/C cg00750074 chr16:89608354 SPG7 -0.49 -7.64 -0.39 2.36e-13 Multiple myeloma (IgH translocation); CRC cis rs523522 0.962 rs4766969 chr12:120988238 A/G cg12219531 chr12:120966889 COQ5 0.69 9.24 0.45 3.2e-18 High light scatter reticulocyte count; CRC cis rs4629710 0.592 rs4424112 chr6:131563788 C/T cg12606694 chr6:131520996 AKAP7 0.56 8.28 0.42 3.12e-15 Multiple myeloma (IgH translocation); CRC cis rs4604732 0.527 rs77361748 chr1:247626475 C/T cg12754571 chr1:247694271 LOC148824;OR2C3 0.41 5.78 0.3 1.74e-8 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CRC cis rs6570726 0.935 rs386823 chr6:145841365 C/T cg05347473 chr6:146136440 FBXO30 0.37 6.0 0.31 5.27e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs2153535 0.580 rs2327050 chr6:8440630 A/G cg07606381 chr6:8435919 SLC35B3 0.68 10.86 0.51 1.08e-23 Motion sickness; CRC trans rs11098499 0.754 rs2036856 chr4:120249288 G/A cg25214090 chr10:38739885 LOC399744 0.53 8.34 0.42 2e-15 Corneal astigmatism; CRC cis rs9768139 0.733 rs13221388 chr7:158119270 G/A cg23298862 chr7:158159286 PTPRN2 0.38 5.98 0.31 5.8e-9 Calcium levels; CRC cis rs2398893 0.924 rs11789837 chr9:96817369 T/G cg14459158 chr9:96720562 NA 0.42 6.92 0.36 2.39e-11 Waist-hip ratio;Waist-to-hip ratio adjusted for body mass index; CRC cis rs10927875 0.541 rs1739840 chr1:16342237 A/G cg10494257 chr1:16342123 HSPB7 0.45 6.33 0.33 7.97e-10 Dilated cardiomyopathy; CRC cis rs881375 0.967 rs7864019 chr9:123692868 A/T cg09419670 chr9:123605666 PSMD5;LOC253039 0.57 8.48 0.42 7.73e-16 Rheumatoid arthritis; CRC cis rs34375054 0.624 rs4073534 chr12:125671800 C/T cg25124228 chr12:125621409 AACS -0.52 -6.67 -0.35 1.05e-10 Post bronchodilator FEV1/FVC ratio; CRC cis rs4243830 0.850 rs12046229 chr1:6580397 C/T cg06972903 chr1:6580525 PLEKHG5 -0.62 -5.78 -0.3 1.71e-8 Body mass index; CRC cis rs4474465 0.790 rs10899541 chr11:78245573 A/G cg27205649 chr11:78285834 NARS2 -0.51 -6.58 -0.34 1.85e-10 Alzheimer's disease (survival time); CRC cis rs2197308 0.765 rs11182900 chr12:37934009 C/T cg13010199 chr12:38710504 ALG10B 0.44 5.62 0.3 4.08e-8 Morning vs. evening chronotype; CRC cis rs10982256 0.875 rs10759710 chr9:117252598 C/T cg13636371 chr9:117264095 DFNB31 0.4 7.6 0.39 3.18e-13 Bipolar disorder; CRC cis rs10782582 0.592 rs7513194 chr1:76382664 A/C cg05598546 chr1:76251766 SNORD45C;RABGGTB -0.43 -5.75 -0.3 2.02e-8 Daytime sleep phenotypes; CRC cis rs7173389 1.000 rs8035896 chr15:73664310 T/G cg01796676 chr15:73680284 NA 0.5 6.72 0.35 7.88e-11 Resting heart rate; CRC trans rs4650994 0.525 rs2224811 chr1:178544323 C/T cg05059571 chr16:84539110 KIAA1609 0.61 8.3 0.42 2.79e-15 HDL cholesterol levels;HDL cholesterol; CRC cis rs9906944 0.545 rs12939375 chr17:47089717 C/G cg10950924 chr17:47092072 IGF2BP1 -0.36 -6.15 -0.32 2.2e-9 Intelligence (multi-trait analysis);Body fat percentage; CRC cis rs754466 0.580 rs2289308 chr10:79579251 G/A cg17075019 chr10:79541650 NA -0.95 -17.74 -0.7 7.08e-50 Liver enzyme levels (gamma-glutamyl transferase); CRC trans rs28643277 0.633 rs3178793 chr10:15556102 T/C cg18315834 chr14:64909119 MTHFD1 0.42 6.07 0.32 3.59e-9 Periodontitis (CDC/AAP); CRC cis rs6761276 0.649 rs3827763 chr2:113831289 C/T cg12858261 chr2:113808755 IL1F8 -0.44 -6.55 -0.34 2.18e-10 Protein quantitative trait loci; CRC cis rs2839186 0.771 rs13046451 chr21:47641373 T/A cg05896524 chr21:47604654 C21orf56 -0.48 -7.28 -0.37 2.5e-12 Testicular germ cell tumor; CRC cis rs6570726 0.846 rs973856 chr6:145781916 C/T cg13319975 chr6:146136371 FBXO30 0.42 6.61 0.34 1.58e-10 Lobe attachment (rater-scored or self-reported); CRC cis rs501916 0.634 rs3803349 chr15:48064867 T/A cg16110827 chr15:48056943 SEMA6D -0.45 -6.62 -0.34 1.43e-10 Inflammatory bowel disease;Ulcerative colitis; CRC cis rs853679 0.517 rs9380060 chr6:28132603 G/A cg18032046 chr6:28092343 ZSCAN16 -0.51 -5.93 -0.31 7.47e-9 Depression; CRC cis rs1218582 0.772 rs906593 chr1:154885255 G/A cg16680214 chr1:154839983 KCNN3 -0.45 -8.95 -0.44 2.62e-17 Prostate cancer; CRC cis rs9650657 0.538 rs11250093 chr8:10798828 C/T cg27411982 chr8:10470053 RP1L1 0.39 5.68 0.3 2.94e-8 Neuroticism; CRC cis rs4862750 0.872 rs6852907 chr4:187897094 A/C cg03452623 chr4:187889614 NA -0.93 -22.01 -0.77 1.17e-66 Lobe attachment (rater-scored or self-reported); CRC cis rs8072100 0.666 rs6503804 chr17:45772447 G/A cg08085267 chr17:45401833 C17orf57 -0.44 -6.43 -0.33 4.61e-10 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs6930083 0.527 rs9368950 chr6:36627872 T/C cg08179530 chr6:36648295 CDKN1A -0.56 -8.41 -0.42 1.28e-15 Coronary artery disease; CRC trans rs79976124 0.879 rs12214239 chr6:66636059 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.77 9.59 0.47 2.32e-19 Type 2 diabetes; CRC cis rs3768617 0.510 rs10752902 chr1:183090265 T/A ch.1.3577855R chr1:183094577 LAMC1 0.89 15.86 0.66 1.84e-42 Fuchs's corneal dystrophy; CRC cis rs514406 0.861 rs10888755 chr1:53240829 A/G cg25767906 chr1:53392781 SCP2 0.46 7.53 0.38 4.87e-13 Monocyte count; CRC cis rs754466 0.651 rs10824582 chr10:79603688 T/C cg26805224 chr10:79626177 DLG5 -0.56 -8.26 -0.41 3.57e-15 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs7208859 0.623 rs9890855 chr17:29111707 G/C cg13385521 chr17:29058706 SUZ12P 0.73 8.4 0.42 1.39e-15 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs9359856 0.673 rs1179897 chr6:90318624 T/C cg13799429 chr6:90582589 CASP8AP2 -0.61 -8.25 -0.41 3.78e-15 Bipolar disorder; CRC cis rs1707322 0.752 rs3811436 chr1:46125880 T/C cg06784218 chr1:46089804 CCDC17 0.65 12.18 0.56 2e-28 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs9435341 0.965 rs1762485 chr1:107625056 C/T cg14828511 chr1:107599125 PRMT6 -0.53 -7.31 -0.37 2.1e-12 Facial morphology (factor 21, depth of nasal alae); CRC cis rs4689388 0.890 rs4689398 chr4:6302199 C/T cg25554036 chr4:6271136 WFS1 0.53 8.56 0.43 4.24e-16 Type 2 diabetes and other traits;Type 2 diabetes; CRC cis rs9287719 0.967 rs4613248 chr2:10744051 C/T cg00105475 chr2:10696890 NA 0.45 7.3 0.37 2.19e-12 Prostate cancer; CRC cis rs10089 1.000 rs72794396 chr5:127501386 G/A cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.73 9.55 0.47 3.2e-19 Ileal carcinoids; CRC cis rs73206853 0.925 rs12297709 chr12:110901758 A/G cg12870014 chr12:110450643 ANKRD13A 0.7 8.68 0.43 1.82e-16 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC cis rs4713118 0.513 rs149989 chr6:27998184 T/A cg23161317 chr6:28129485 ZNF389 0.45 6.52 0.34 2.72e-10 Parkinson's disease; CRC cis rs372883 0.901 rs407463 chr21:30722440 G/A cg24692254 chr21:30365293 RNF160 -0.39 -5.96 -0.31 6.44e-9 Pancreatic cancer; CRC cis rs10946940 0.930 rs12215012 chr6:27507494 C/G cg15845792 chr6:28175446 NA -0.45 -6.12 -0.32 2.65e-9 Systemic lupus erythematosus; CRC cis rs7809950 1.000 rs12668402 chr7:107173020 G/A cg23024343 chr7:107201750 COG5 -0.6 -8.68 -0.43 1.81e-16 Coronary artery disease; CRC trans rs1814175 0.754 rs10219245 chr11:49645052 C/T cg11707556 chr5:10655725 ANKRD33B -0.42 -7.79 -0.39 9.04e-14 Height; CRC cis rs6570726 0.935 rs387965 chr6:145869366 A/G cg05347473 chr6:146136440 FBXO30 0.39 6.18 0.32 1.91e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs6761276 0.868 rs13386602 chr2:113834820 A/C cg09040174 chr2:113837401 NA 0.65 10.3 0.49 9.83e-22 Protein quantitative trait loci; CRC cis rs2404602 0.716 rs17461634 chr15:76764107 G/A cg03037974 chr15:76606532 NA 0.74 13.26 0.59 1.96e-32 Blood metabolite levels; CRC cis rs7044106 0.718 rs10616 chr9:123363533 T/C cg14255062 chr9:123606675 PSMD5;LOC253039 0.38 5.76 0.3 1.89e-8 Hip circumference adjusted for BMI; CRC cis rs11122272 0.735 rs2790897 chr1:231491712 C/A cg06096015 chr1:231504339 EGLN1 0.39 5.69 0.3 2.8e-8 Hemoglobin concentration; CRC cis rs6500602 0.727 rs55939215 chr16:4541390 C/G cg08645402 chr16:4508243 NA 0.59 10.35 0.5 6.37e-22 Schizophrenia; CRC cis rs2742417 0.603 rs2742458 chr3:45767602 C/T cg04837898 chr3:45731254 SACM1L -0.48 -7.69 -0.39 1.74e-13 Response to anti-depressant treatment in major depressive disorder; CRC trans rs2727020 0.664 rs4929893 chr11:49196332 C/T cg21153622 chr11:89784906 NA -0.42 -6.8 -0.35 4.94e-11 Coronary artery disease; CRC cis rs908922 0.676 rs578382 chr1:152514054 A/G cg09873164 chr1:152488093 CRCT1 -0.39 -6.58 -0.34 1.87e-10 Hair morphology; CRC cis rs875971 0.790 rs10257911 chr7:65743770 A/G cg11764359 chr7:65958608 NA -0.6 -8.74 -0.43 1.19e-16 Aortic root size; CRC cis rs760805 1.000 rs4648884 chr1:25261386 C/T cg22509179 chr1:25234806 RUNX3 0.58 9.33 0.46 1.55e-18 Allergic disease (asthma, hay fever or eczema); CRC cis rs1355223 0.506 rs11032898 chr11:34870111 C/G cg11058730 chr11:34937778 PDHX;APIP -0.43 -6.08 -0.32 3.26e-9 Systemic lupus erythematosus and Systemic sclerosis; CRC trans rs9291683 0.935 rs1860910 chr4:10275470 T/G cg26043149 chr18:55253948 FECH 0.46 7.41 0.38 1.1e-12 Bone mineral density; CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg17286491 chr1:179923514 CEP350 -0.53 -6.43 -0.33 4.47e-10 Diisocyanate-induced asthma; CRC cis rs2836950 0.565 rs7278297 chr21:40625752 A/C cg06238570 chr21:40685208 BRWD1 -0.64 -9.24 -0.45 3.12e-18 Menarche (age at onset); CRC cis rs10464366 0.544 rs1525799 chr7:39153131 C/G cg18850127 chr7:39170497 POU6F2 -0.55 -7.35 -0.38 1.54e-12 IgG glycosylation; CRC trans rs7027930 0.560 rs10758737 chr9:610960 G/C cg27061366 chr19:13044373 FARSA 0.52 6.38 0.33 6.13e-10 Pulmonary function decline; CRC cis rs7618915 0.501 rs34739010 chr3:52766122 A/G cg15147215 chr3:52552868 STAB1 -0.63 -10.74 -0.51 2.95e-23 Bipolar disorder; CRC cis rs2739330 0.627 rs9608219 chr22:24274119 G/C cg16132339 chr22:24313637 DDTL;DDT 0.67 11.12 0.52 1.29e-24 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs12477438 0.520 rs2171359 chr2:99795360 T/C cg26064155 chr2:99771622 LIPT1;TSGA10 0.87 15.96 0.66 7.31e-43 Chronic sinus infection; CRC cis rs3888647 0.622 rs4758618 chr11:2995186 A/T cg08508325 chr11:3079039 CARS -0.41 -7.44 -0.38 8.78e-13 Type 2 diabetes; CRC cis rs7666738 0.606 rs13108868 chr4:99083753 C/T cg05340658 chr4:99064831 C4orf37 0.49 7.21 0.37 3.95e-12 Colonoscopy-negative controls vs population controls; CRC cis rs9816226 0.591 rs1516725 chr3:185824004 T/C cg00760338 chr3:185826511 ETV5 0.65 5.78 0.3 1.72e-8 Obesity;Body mass index; CRC cis rs7937682 0.921 rs688354 chr11:111438762 A/G cg09085632 chr11:111637200 PPP2R1B -0.96 -16.77 -0.68 4.65e-46 Primary sclerosing cholangitis; CRC cis rs1005277 0.522 rs1208684 chr10:38093936 G/A cg25517755 chr10:38738941 LOC399744 -0.43 -6.29 -0.33 9.92e-10 Extrinsic epigenetic age acceleration; CRC cis rs514406 0.825 rs6693210 chr1:53223398 A/G cg25767906 chr1:53392781 SCP2 0.45 7.12 0.37 6.95e-12 Monocyte count; CRC cis rs847577 0.748 rs55784506 chr7:97718201 G/A cg00277769 chr7:97922759 BAIAP2L1 -0.4 -6.73 -0.35 7.54e-11 Breast cancer; CRC cis rs2857891 0.909 rs56372435 chr11:6938658 T/C cg02416716 chr11:6948024 ZNF215 0.57 5.86 0.31 1.14e-8 Response to cytadine analogues (cytosine arabinoside); CRC cis rs8031584 0.560 rs1056118 chr15:31203786 G/A cg08109568 chr15:31115862 NA 0.41 6.66 0.34 1.13e-10 Huntington's disease progression; CRC cis rs6088590 0.523 rs6088536 chr20:33189106 T/C cg24642439 chr20:33292090 TP53INP2 0.39 6.63 0.34 1.36e-10 Coronary artery disease; CRC cis rs736801 0.808 rs2706396 chr5:131796809 A/C cg14196790 chr5:131705035 SLC22A5 -0.35 -5.67 -0.3 3.18e-8 Breast cancer;Mosquito bite size; CRC cis rs12142240 0.698 rs6703669 chr1:46862555 C/T cg14993813 chr1:46806288 NSUN4 -0.48 -6.03 -0.32 4.47e-9 Menopause (age at onset); CRC cis rs9969804 0.818 rs6479429 chr9:95501785 A/T cg14631576 chr9:95140430 CENPP -0.32 -5.97 -0.31 6.03e-9 Height; CRC cis rs6662572 0.737 rs4660315 chr1:46270942 G/C cg03123370 chr1:45965343 CCDC163P;MMACHC -0.48 -6.22 -0.32 1.52e-9 Blood protein levels; CRC cis rs7220401 0.512 rs71371126 chr17:28002642 G/A cg26525008 chr17:28256777 EFCAB5;SSH2 -0.59 -8.07 -0.41 1.34e-14 Coronary artery disease; CRC cis rs13161895 1.000 rs4235504 chr5:179453680 T/C cg02702477 chr5:179499311 RNF130 0.54 6.21 0.32 1.61e-9 LDL cholesterol; CRC cis rs12188164 0.965 rs11743639 chr5:450710 C/T cg15813090 chr5:442598 EXOC3;C5orf55 0.39 5.63 0.3 3.9e-8 Cystic fibrosis severity; CRC cis rs1218582 0.745 rs1580943 chr1:154865125 G/A cg06221963 chr1:154839813 KCNN3 -0.78 -15.86 -0.66 1.71e-42 Prostate cancer; CRC cis rs4713118 0.527 rs4713151 chr6:28136356 G/A cg18032046 chr6:28092343 ZSCAN16 -0.51 -5.93 -0.31 7.47e-9 Parkinson's disease; CRC cis rs733592 0.507 rs7299704 chr12:48444488 A/G cg24011408 chr12:48396354 COL2A1 0.46 6.79 0.35 5.16e-11 Plateletcrit; CRC cis rs3806843 0.741 rs4912597 chr5:140106857 C/G cg19875535 chr5:140030758 IK -0.63 -10.27 -0.49 1.2e-21 Depressive symptoms (multi-trait analysis); CRC cis rs2179367 0.887 rs506268 chr6:149685617 C/T cg07828024 chr6:149772892 ZC3H12D -0.36 -6.01 -0.31 4.94e-9 Dupuytren's disease; CRC cis rs2230307 0.536 rs490669 chr1:100484430 C/T cg24955406 chr1:100503596 HIAT1 0.59 7.01 0.36 1.34e-11 Carotid intima media thickness; CRC cis rs12477438 0.520 rs11123763 chr2:99750673 A/G cg14399236 chr2:99771627 LIPT1;TSGA10 0.82 14.44 0.62 5.96e-37 Chronic sinus infection; CRC cis rs2836974 0.568 rs2183573 chr21:40574305 A/G cg17971929 chr21:40555470 PSMG1 -0.72 -11.21 -0.53 6.29e-25 Cognitive function; CRC trans rs7267979 0.966 rs2151144 chr20:25414924 G/C cg17903999 chr18:56338584 MALT1 0.41 6.71 0.35 8.45e-11 Liver enzyme levels (alkaline phosphatase); CRC cis rs7408868 1.000 rs10422818 chr19:15285272 A/G cg14696996 chr19:15285081 NOTCH3 0.85 8.18 0.41 6.31e-15 Pulse pressure; CRC cis rs9910055 0.529 rs228748 chr17:42174390 G/A cg13607699 chr17:42295918 UBTF -0.5 -6.55 -0.34 2.26e-10 Total body bone mineral density; CRC cis rs6831352 1.000 rs10017466 chr4:100055800 C/T cg13256891 chr4:100009986 ADH5 0.57 8.28 0.42 3.14e-15 Alcohol dependence; CRC cis rs1949733 1.000 rs1949733 chr4:8503359 C/T cg11789530 chr4:8429930 ACOX3 -0.85 -12.66 -0.57 3.37e-30 Response to antineoplastic agents; CRC cis rs11792861 0.781 rs11793272 chr9:111762102 G/A cg05043794 chr9:111880884 C9orf5 -0.33 -5.75 -0.3 2.01e-8 Menarche (age at onset); CRC cis rs2580764 0.566 rs2968794 chr2:55290651 C/G cg09592903 chr2:55203963 RTN4 -0.71 -11.52 -0.54 4.82e-26 Mean platelet volume; CRC cis rs72945132 0.882 rs10466703 chr11:70218548 C/T cg00319359 chr11:70116639 PPFIA1 0.6 6.65 0.34 1.22e-10 Coronary artery disease; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg18058077 chr11:319009 NA 0.42 6.63 0.34 1.35e-10 Liver disease severity in Alagille syndrome; CRC cis rs3823572 0.542 rs2346267 chr7:133639554 T/C cg03336402 chr7:133662267 EXOC4 0.66 10.02 0.48 8.55e-21 Intelligence (multi-trait analysis); CRC cis rs4862750 0.872 rs6553030 chr4:187899234 T/C cg27532560 chr4:187881888 NA -0.57 -10.58 -0.5 1.04e-22 Lobe attachment (rater-scored or self-reported); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg01519350 chr3:137906342 ARMC8 0.48 6.91 0.36 2.59e-11 Response to antipsychotic treatment; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg16590012 chr1:1265354 TAS1R3 -0.37 -6.49 -0.34 3.11e-10 Liver disease severity in Alagille syndrome; CRC cis rs11190604 0.945 rs11190553 chr10:102207959 T/C cg16342193 chr10:102329863 NA -0.37 -6.17 -0.32 2.02e-9 Palmitoleic acid (16:1n-7) levels; CRC cis rs1129187 0.755 rs9471982 chr6:42935998 G/A cg21280719 chr6:42927975 GNMT -0.46 -10.44 -0.5 3.2e-22 Alzheimer's disease in APOE e4+ carriers; CRC cis rs6088580 0.608 rs2105109 chr20:32971932 A/G cg08999081 chr20:33150536 PIGU -0.6 -11.21 -0.53 6.38e-25 Glomerular filtration rate (creatinine); CRC cis rs4713118 0.586 rs6905516 chr6:28086478 A/G cg23161317 chr6:28129485 ZNF389 0.54 6.56 0.34 2.12e-10 Parkinson's disease; CRC trans rs2840044 1.000 rs225262 chr17:33959697 A/G cg19694781 chr19:47549865 TMEM160 -0.46 -7.27 -0.37 2.72e-12 Response to radiotherapy in cancer (late toxicity); CRC cis rs9916302 0.904 rs9894500 chr17:37515735 G/C cg07936489 chr17:37558343 FBXL20 0.83 12.7 0.57 2.44e-30 Glomerular filtration rate (creatinine); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg08408563 chr2:120980996 TMEM185B 0.42 6.22 0.32 1.52e-9 Intelligence (multi-trait analysis); CRC trans rs916888 0.773 rs199445 chr17:44817408 C/T cg23590916 chr17:43697445 MGC57346 0.69 7.23 0.37 3.41e-12 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs7267979 1.000 rs6083844 chr20:25386832 C/T cg24626310 chr20:25276739 ABHD12;PYGB -0.34 -5.79 -0.3 1.62e-8 Liver enzyme levels (alkaline phosphatase); CRC cis rs3008870 1.000 rs2755240 chr1:67477339 T/G cg08660285 chr1:67390436 MIER1;WDR78 1.0 14.7 0.63 5.68e-38 Lymphocyte percentage of white cells; CRC cis rs912057 1.000 rs1294407 chr6:6738103 C/G cg06612196 chr6:6737390 NA 0.55 8.7 0.43 1.64e-16 Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction); CRC cis rs7584330 0.518 rs74003109 chr2:238448150 C/T cg08992911 chr2:238395768 MLPH 0.57 5.85 0.31 1.2e-8 Prostate cancer; CRC cis rs12220238 1.000 rs7905536 chr10:75997209 G/C cg19889307 chr10:75911429 ADK;AP3M1 0.56 5.71 0.3 2.46e-8 Soluble interleukin-2 receptor subunit alpha; CRC cis rs769267 0.930 rs4808964 chr19:19603692 A/C cg03709012 chr19:19516395 GATAD2A -0.72 -11.22 -0.53 5.71e-25 Tonsillectomy; CRC cis rs17155006 0.746 rs366690 chr7:107749880 T/G cg05962710 chr7:107745446 LAMB4 -0.41 -7.33 -0.37 1.77e-12 Pneumococcal bacteremia; CRC cis rs881375 0.678 rs7031752 chr9:123663482 G/T cg09419670 chr9:123605666 PSMD5;LOC253039 0.52 8.32 0.42 2.35e-15 Rheumatoid arthritis; CRC cis rs11209185 0.509 rs9326078 chr1:68452388 A/G cg22082780 chr1:68452167 NA 0.5 7.95 0.4 2.98e-14 Itch intensity from mosquito bite adjusted by bite size; CRC cis rs10504229 0.683 rs55868006 chr8:58135703 C/T cg24829409 chr8:58192753 C8orf71 -0.55 -8.03 -0.4 1.71e-14 Developmental language disorder (linguistic errors); CRC cis rs8044995 0.563 rs7500163 chr16:68364358 C/G cg09835421 chr16:68378352 PRMT7 -0.75 -7.79 -0.39 8.77e-14 Schizophrenia; CRC cis rs172166 0.652 rs476167 chr6:28065888 T/C cg12172441 chr6:28176163 NA 0.53 7.32 0.37 1.96e-12 Cardiac Troponin-T levels; CRC trans rs2727020 0.731 rs10450572 chr11:49281073 T/C cg21153622 chr11:89784906 NA 0.43 7.15 0.37 5.77e-12 Coronary artery disease; CRC cis rs16975963 0.843 rs60731897 chr19:38269259 C/A cg15135657 chr19:38346511 NA -0.44 -5.89 -0.31 9.55e-9 Longevity; CRC cis rs12971120 1.000 rs3829640 chr18:72174980 A/G cg26446133 chr18:72167187 CNDP2 -0.77 -12.69 -0.57 2.64e-30 Refractive error; CRC trans rs7615952 0.546 rs2979306 chr3:125312130 C/A cg16558177 chr4:4109446 NA -0.52 -6.24 -0.33 1.32e-9 Blood pressure (smoking interaction); CRC cis rs9783347 1.000 rs7947378 chr11:18381327 T/C cg15585147 chr11:18324498 HPS5 0.46 6.5 0.34 3.03e-10 Pancreatic cancer; CRC cis rs2354432 0.556 rs11239965 chr1:146753907 C/A cg25205988 chr1:146714368 CHD1L -1.23 -9.95 -0.48 1.45e-20 Mitochondrial DNA levels; CRC cis rs10971721 0.822 rs10971735 chr9:33851799 T/C cg13495928 chr9:33750294 PRSS3 0.55 5.9 0.31 9.17e-9 Body mass index; CRC cis rs2806561 0.765 rs641808 chr1:23514123 T/G cg12483005 chr1:23474871 LUZP1 0.49 7.13 0.37 6.42e-12 Height; CRC cis rs427941 0.550 rs201523 chr7:101771851 C/T cg06246474 chr7:101738831 CUX1 0.37 5.67 0.3 3.17e-8 Plasma omega-3 polyunsaturated fatty acid level (eicosapentaenoic acid); CRC cis rs6424115 0.830 rs2502994 chr1:24199363 T/C cg09473613 chr1:24152604 HMGCL 0.35 5.66 0.3 3.35e-8 Immature fraction of reticulocytes; CRC cis rs3858526 0.523 rs10742818 chr11:5882535 T/C cg05234568 chr11:5960015 NA -0.65 -9.24 -0.45 3.12e-18 DNA methylation (variation); CRC trans rs11722228 0.508 rs9732 chr4:10076658 T/C cg26043149 chr18:55253948 FECH 1.15 18.72 0.72 9.24e-54 Gout;Urate levels;Serum uric acid levels; CRC cis rs9611519 0.828 rs9611460 chr22:41418297 T/C cg03806693 chr22:41940476 POLR3H -0.52 -6.01 -0.31 4.91e-9 Neuroticism; CRC cis rs4481887 1.000 rs4916128 chr1:248466706 G/A cg13385794 chr1:248469461 NA 0.39 6.98 0.36 1.62e-11 Common traits (Other); CRC cis rs6951245 0.554 rs10246354 chr7:1132456 C/T cg18402987 chr7:1209562 NA 0.51 6.07 0.32 3.45e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs2692947 0.727 rs2692950 chr2:96673524 T/C cg23100626 chr2:96804247 ASTL 0.25 6.78 0.35 5.61e-11 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; CRC cis rs2072510 0.593 rs2540497 chr12:96404275 A/T cg22491680 chr12:96389547 HAL -0.47 -5.84 -0.31 1.25e-8 Metabolite levels (small molecules and protein measures); CRC cis rs561341 0.831 rs11658469 chr17:30206426 T/C cg23018236 chr17:30244563 NA 0.52 6.64 0.34 1.3100000000000001e-10 Hip circumference adjusted for BMI; CRC cis rs1552244 0.882 rs55840655 chr3:10042690 C/T cg10729496 chr3:10149963 C3orf24 0.49 6.34 0.33 7.69e-10 Alzheimer's disease; CRC cis rs1218582 0.803 rs7531728 chr1:154840516 C/A cg06221963 chr1:154839813 KCNN3 -0.83 -15.95 -0.66 7.62e-43 Prostate cancer; CRC cis rs73206853 0.688 rs56691704 chr12:110568623 A/G cg12870014 chr12:110450643 ANKRD13A 0.82 9.4 0.46 9.47e-19 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC cis rs9462027 0.628 rs2814961 chr6:34706951 C/T cg07306190 chr6:34760872 UHRF1BP1 -0.34 -6.07 -0.32 3.49e-9 Systemic lupus erythematosus; CRC cis rs1336900 0.513 rs56253522 chr1:150614869 C/A cg10589385 chr1:150898437 SETDB1 0.31 6.48 0.34 3.43e-10 Blood protein levels; CRC cis rs7208859 0.673 rs216418 chr17:28936537 G/A cg01831904 chr17:28903510 LRRC37B2 -0.54 -6.42 -0.33 4.63e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs9611565 0.569 rs188057 chr22:41822305 T/G cg03806693 chr22:41940476 POLR3H 1.1 13.52 0.6 1.95e-33 Vitiligo; CRC cis rs7552404 0.731 rs61770556 chr1:76421902 T/C cg22875332 chr1:76189707 ACADM 0.63 7.3 0.37 2.24e-12 Blood metabolite levels;Acylcarnitine levels; CRC cis rs4713675 0.565 rs4711340 chr6:33681131 C/T cg14003231 chr6:33640908 ITPR3 0.51 8.25 0.41 3.77e-15 Plateletcrit; CRC cis rs877282 0.583 rs11253424 chr10:813426 C/T cg17470449 chr10:769945 NA 0.53 7.97 0.4 2.58e-14 Uric acid levels; CRC cis rs8060686 1.000 rs8060686 chr16:67911517 T/C cg01951491 chr16:67709440 GFOD2 -0.45 -5.9 -0.31 9.23e-9 HDL cholesterol;Metabolic syndrome; CRC cis rs13217239 0.646 rs10456352 chr6:26990358 A/T cg12292205 chr6:26970375 C6orf41 0.56 9.32 0.46 1.78e-18 Schizophrenia; CRC cis rs637571 0.510 rs4930320 chr11:65576788 C/G cg04055107 chr11:65626734 MUS81;CFL1 -0.42 -6.01 -0.31 4.95e-9 Eosinophil percentage of white cells; CRC trans rs57221529 0.766 rs72706608 chr5:559203 C/T cg11887960 chr12:57824829 NA 0.58 6.44 0.33 4.17e-10 Lung disease severity in cystic fibrosis; CRC cis rs7605827 0.930 rs1015837 chr2:15665847 C/T cg19274914 chr2:15703543 NA 0.37 5.7 0.3 2.62e-8 Educational attainment (years of education); CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg17344085 chr7:100450162 SLC12A9 0.49 6.97 0.36 1.75e-11 Anxiety disorder; CRC cis rs2228479 1.000 rs117406136 chr16:89974605 C/T cg06656553 chr16:89960601 TCF25 -0.68 -5.99 -0.31 5.35e-9 Skin colour saturation; CRC cis rs8180040 0.966 rs62260711 chr3:47564491 G/C cg10298567 chr3:47292165 KIF9 0.37 5.8 0.3 1.58e-8 Colorectal cancer; CRC cis rs4423214 0.840 rs1790343 chr11:71177207 T/C cg05163923 chr11:71159392 DHCR7 -0.64 -7.64 -0.39 2.32e-13 Vitamin D levels; CRC cis rs6502050 0.835 rs6502069 chr17:80112599 G/T cg19223190 chr17:80058835 NA 0.4 6.36 0.33 6.88e-10 Life satisfaction; CRC cis rs10197940 0.624 rs6724796 chr2:152412813 C/T cg06191203 chr2:152266755 RIF1 -0.57 -8.52 -0.42 6.02e-16 Lung cancer; CRC cis rs1448094 0.522 rs12313658 chr12:86271063 C/T cg25456477 chr12:86230367 RASSF9 0.32 5.63 0.3 3.83e-8 Major depressive disorder; CRC cis rs78456975 1.000 rs11899027 chr2:1560414 G/C cg01028140 chr2:1542097 TPO -0.58 -6.13 -0.32 2.54e-9 Placebo response in major depressive disorder (% change in symptom score); CRC cis rs6456156 0.846 rs9364891 chr6:167516319 C/T cg05540913 chr6:167530185 CCR6 -0.34 -6.0 -0.31 5.1e-9 Primary biliary cholangitis; CRC cis rs7487075 0.859 rs7968173 chr12:46759017 A/T cg22049899 chr12:47219821 SLC38A4 -0.32 -6.01 -0.31 4.99e-9 Itch intensity from mosquito bite; CRC trans rs360798 0.512 rs17027429 chr2:63079983 C/T cg05376469 chr2:102649931 NA -0.36 -6.03 -0.32 4.51e-9 Coronary artery disease; CRC cis rs3806843 0.900 rs2563254 chr5:140142701 T/C cg19875535 chr5:140030758 IK -0.55 -8.8 -0.44 7.81e-17 Depressive symptoms (multi-trait analysis); CRC cis rs2075371 1.000 rs2598285 chr7:133971153 A/T cg20476274 chr7:133979776 SLC35B4 0.78 14.05 0.61 1.88e-35 Mean platelet volume; CRC cis rs780096 0.546 rs12473776 chr2:27636474 A/G cg22903471 chr2:27725779 GCKR -0.37 -6.07 -0.32 3.43e-9 Total body bone mineral density; CRC cis rs9891119 0.550 rs11079043 chr17:40545770 T/C cg06270615 chr17:40516068 STAT3 0.31 6.34 0.33 7.58e-10 Multiple sclerosis;Crohn's disease; CRC cis rs1552244 0.882 rs13063098 chr3:10009919 G/A cg18598329 chr3:10140678 FANCD2;C3orf24 -0.82 -10.72 -0.51 3.38e-23 Alzheimer's disease; CRC cis rs10504229 1.000 rs67237174 chr8:58175776 T/C cg01721255 chr8:58191610 C8orf71 0.49 6.12 0.32 2.66e-9 Developmental language disorder (linguistic errors); CRC cis rs17023223 0.537 rs17023174 chr1:119593301 T/C cg05756136 chr1:119680316 WARS2 -0.46 -6.24 -0.33 1.33e-9 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for BMI in active individuals; CRC cis rs4660306 1.000 rs4660870 chr1:45995231 T/A cg03123370 chr1:45965343 CCDC163P;MMACHC -0.53 -7.52 -0.38 5.27e-13 Homocysteine levels; CRC cis rs870825 0.616 rs6844146 chr4:185636396 G/A cg04058563 chr4:185651563 MLF1IP 0.73 9.38 0.46 1.13e-18 Blood protein levels; CRC trans rs2710642 0.821 rs2710639 chr2:63138963 C/T cg05376469 chr2:102649931 NA -0.38 -6.07 -0.32 3.5e-9 LDL cholesterol levels;LDL cholesterol; CRC cis rs4588572 0.643 rs6861678 chr5:77764613 G/C cg11547950 chr5:77652471 NA -0.54 -7.25 -0.37 3.03e-12 Triglycerides; CRC cis rs1552244 0.832 rs115415687 chr3:10195704 C/T cg10729496 chr3:10149963 C3orf24 0.61 7.18 0.37 4.55e-12 Alzheimer's disease; CRC cis rs748404 0.631 rs7166812 chr15:43644760 T/C cg02155558 chr15:43621948 ADAL;LCMT2 0.53 7.76 0.39 1.09e-13 Lung cancer; CRC cis rs11608355 0.515 rs12831026 chr12:109903651 C/T cg05360138 chr12:110035743 NA 0.77 8.7 0.43 1.65e-16 Neuroticism; CRC cis rs45544231 0.569 rs11642645 chr16:52558907 C/A cg09051775 chr16:52580266 TOX3 -0.38 -6.09 -0.32 3.13e-9 Restless legs syndrome; CRC cis rs6693567 0.507 rs9436120 chr1:150473084 T/C cg15654264 chr1:150340011 RPRD2 0.4 5.72 0.3 2.36e-8 Migraine; CRC cis rs7737355 0.947 rs3776030 chr5:130776738 A/G cg06307176 chr5:131281290 NA -0.42 -6.15 -0.32 2.2e-9 Life satisfaction; CRC cis rs8180040 0.966 rs878659 chr3:47500662 G/A cg02527881 chr3:46936655 PTH1R -0.41 -7.82 -0.4 7.1e-14 Colorectal cancer; CRC cis rs651907 0.535 rs11717638 chr3:101505468 A/G cg12386194 chr3:101231763 SENP7 0.52 7.66 0.39 2.12e-13 Colorectal cancer; CRC cis rs896854 0.812 rs12546365 chr8:95911477 T/C cg23172400 chr8:95962367 TP53INP1 -0.45 -7.46 -0.38 7.62e-13 Type 2 diabetes; CRC cis rs6564851 0.506 rs56389940 chr16:81259152 C/A cg05274606 chr16:81253692 PKD1L2 -0.38 -6.28 -0.33 1.05e-9 Carotenoid and tocopherol levels; CRC cis rs12908161 1.000 rs12912388 chr15:85344550 T/A cg11189052 chr15:85197271 WDR73 0.58 8.28 0.42 3.08e-15 Schizophrenia; CRC cis rs55788414 0.932 rs8043592 chr16:81182537 A/G cg06400318 chr16:81190750 PKD1L2 -0.59 -6.78 -0.35 5.73e-11 Left ventricular obstructive tract defect (maternal effect); CRC cis rs1577917 0.655 rs9444354 chr6:86291935 G/A cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A 0.49 6.95 0.36 2.02e-11 Response to antipsychotic treatment; CRC cis rs9549367 0.865 rs9549366 chr13:113907644 G/A cg00898013 chr13:113819073 PROZ -0.45 -6.45 -0.33 4.06e-10 Platelet distribution width; CRC cis rs748404 0.650 rs518234 chr15:43573421 G/A cg02155558 chr15:43621948 ADAL;LCMT2 0.45 6.68 0.35 1.03e-10 Lung cancer; CRC cis rs1552244 0.554 rs6768339 chr3:10006079 G/T cg13047869 chr3:10149882 C3orf24 -0.38 -5.89 -0.31 9.31e-9 Alzheimer's disease; CRC cis rs7113874 0.589 rs10840051 chr11:8475180 G/C cg20771178 chr11:8615675 STK33 -0.34 -5.6 -0.3 4.46e-8 Body mass index in physically active individuals;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs12142240 0.698 rs6667861 chr1:46815749 T/C cg14993813 chr1:46806288 NSUN4 -0.5 -6.4 -0.33 5.38e-10 Menopause (age at onset); CRC cis rs7762018 0.891 rs12529402 chr6:170147675 A/T cg24289452 chr6:170231220 NA -0.57 -6.39 -0.33 5.75e-10 Thiazide-induced adverse metabolic effects in hypertensive patients; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg10624784 chr7:77427913 PHTF2;TMEM60 0.38 6.09 0.32 3.13e-9 Liver disease severity in Alagille syndrome; CRC cis rs1451375 0.698 rs7797131 chr7:50647934 A/G cg18232548 chr7:50535776 DDC 0.44 6.25 0.33 1.24e-9 Malaria; CRC cis rs635808 0.520 rs656938 chr6:167172048 C/T cg27626620 chr6:167171727 RPS6KA2 0.37 6.31 0.33 9.18e-10 Dental caries; CRC cis rs11997175 0.646 rs55898196 chr8:33765862 A/G cg04338863 chr8:33670619 NA 0.44 6.94 0.36 2.07e-11 Body mass index; CRC cis rs875971 0.830 rs1167406 chr7:65556936 G/C cg18252515 chr7:66147081 NA 0.4 5.9 0.31 9.26e-9 Aortic root size; CRC cis rs9291683 0.632 rs11734375 chr4:10046298 A/G cg11266682 chr4:10021025 SLC2A9 0.53 11.08 0.52 1.85e-24 Bone mineral density; CRC cis rs1448094 0.512 rs6539928 chr12:86244920 G/A cg25456477 chr12:86230367 RASSF9 0.32 5.63 0.3 3.86e-8 Major depressive disorder; CRC trans rs1864585 0.520 rs73208793 chr8:10680785 T/C cg26278703 chr11:58910052 FAM111A 0.56 6.55 0.34 2.24e-10 Neutrophil percentage of white cells;Lymphocyte percentage of white cells; CRC cis rs2976388 0.609 rs2585145 chr8:143799457 G/A cg04969067 chr8:143858791 LYNX1 0.44 7.34 0.37 1.72e-12 Urinary tract infection frequency; CRC trans rs703108 0.731 rs7898954 chr10:22323646 A/G cg10287303 chr10:74855401 P4HA1 -0.51 -6.15 -0.32 2.22e-9 Monocyte percentage of white cells; CRC cis rs7666738 0.830 rs34273190 chr4:99004568 C/T cg17366294 chr4:99064904 C4orf37 0.44 7.44 0.38 8.86e-13 Colonoscopy-negative controls vs population controls; CRC trans rs208520 0.507 rs9453585 chr6:66796668 C/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.15 -25.28 -0.81 4.14e-79 Exhaled nitric oxide output; CRC cis rs2404602 0.692 rs2120108 chr15:76869929 G/T cg23625390 chr15:77176239 SCAPER -0.48 -6.73 -0.35 7.42e-11 Blood metabolite levels; CRC cis rs3857067 1.000 rs899133 chr4:95019609 T/C cg11021082 chr4:95130006 SMARCAD1 -0.4 -6.06 -0.32 3.63e-9 QT interval; CRC cis rs7772486 0.597 rs9285508 chr6:146262697 G/T cg13319975 chr6:146136371 FBXO30 0.62 8.23 0.41 4.36e-15 Lobe attachment (rater-scored or self-reported); CRC cis rs6500602 0.727 rs2058811 chr16:4575162 C/T cg14951292 chr16:4525986 HMOX2;NMRAL1 0.55 8.43 0.42 1.11e-15 Schizophrenia; CRC cis rs684232 0.644 rs2543781 chr17:602469 C/G cg15660573 chr17:549704 VPS53 -0.69 -11.83 -0.55 3.68e-27 Prostate cancer; CRC cis rs28386778 0.865 rs2727276 chr17:61929709 G/A cg11494091 chr17:61959527 GH2 0.59 9.97 0.48 1.2e-20 Prudent dietary pattern; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg14151426 chr13:113864409 CUL4A;PCID2 0.45 6.37 0.33 6.31e-10 Response to antipsychotic treatment; CRC cis rs1552244 0.882 rs17050660 chr3:10001772 A/G cg13047869 chr3:10149882 C3orf24 -0.51 -6.99 -0.36 1.51e-11 Alzheimer's disease; CRC cis rs2839186 0.647 rs9976233 chr21:47616913 G/A cg13126279 chr21:47581558 C21orf56 0.38 6.09 0.32 3.22e-9 Testicular germ cell tumor; CRC cis rs11673344 0.583 rs10425719 chr19:37950798 C/G cg11720556 chr19:37764088 NA -0.41 -5.86 -0.31 1.14e-8 Obesity-related traits; CRC cis rs2839186 0.900 rs2839200 chr21:47709095 C/T cg02776659 chr21:47717406 C21orf57 -0.34 -5.66 -0.3 3.27e-8 Testicular germ cell tumor; CRC cis rs6921919 0.583 rs4254981 chr6:28371402 A/C cg21251018 chr6:28226885 NKAPL 0.39 5.93 0.31 7.61e-9 Autism spectrum disorder or schizophrenia; CRC cis rs78456975 1.000 rs13397299 chr2:1564222 A/C cg26248373 chr2:1572462 NA -0.69 -7.61 -0.39 2.97e-13 Placebo response in major depressive disorder (% change in symptom score); CRC cis rs7927771 0.524 rs6485786 chr11:47837408 G/C cg20307385 chr11:47447363 PSMC3 0.46 6.64 0.34 1.33e-10 Subjective well-being; CRC cis rs62064224 0.905 rs9891969 chr17:30627085 C/T cg18200150 chr17:30822561 MYO1D 0.58 11.86 0.55 2.87e-27 Schizophrenia; CRC cis rs6502050 0.835 rs8078087 chr17:80113322 T/G cg09264619 chr17:80180166 NA -0.34 -5.81 -0.3 1.5e-8 Life satisfaction; CRC cis rs2228479 0.702 rs11076620 chr16:89831520 A/T cg06558623 chr16:89946397 TCF25 1.12 10.45 0.5 2.84e-22 Skin colour saturation; CRC cis rs6502050 0.865 rs8079388 chr17:80162798 C/A cg22110888 chr17:80059540 CCDC57 0.41 6.53 0.34 2.56e-10 Life satisfaction; CRC trans rs9813712 0.597 rs1453255 chr3:129977658 A/G cg23942268 chr17:6347992 FAM64A -0.41 -6.0 -0.31 5.22e-9 Response to amphetamines; CRC cis rs67478160 0.643 rs3818085 chr14:104215985 C/T cg01849466 chr14:104193079 ZFYVE21 -0.49 -8.76 -0.43 1.04e-16 Schizophrenia; CRC trans rs6762477 0.748 rs3755831 chr3:50228767 G/T cg21659725 chr3:3221576 CRBN -0.45 -6.81 -0.35 4.79e-11 Menarche (age at onset); CRC trans rs2727020 0.615 rs10128582 chr11:49447424 C/T cg21153622 chr11:89784906 NA -0.38 -6.26 -0.33 1.18e-9 Coronary artery disease; CRC cis rs8141529 0.702 rs469991 chr22:29307859 G/C cg15103426 chr22:29168792 CCDC117 -0.51 -7.24 -0.37 3.28e-12 Lymphocyte counts; CRC cis rs5769707 0.542 rs739242 chr22:50057116 A/G cg20744362 chr22:50050164 C22orf34 0.32 5.82 0.31 1.38e-8 Monocyte count;Monocyte percentage of white cells; CRC trans rs66887589 0.934 rs6817317 chr4:120542827 A/G cg25214090 chr10:38739885 LOC399744 -0.42 -6.54 -0.34 2.37e-10 Diastolic blood pressure; CRC cis rs4819052 0.635 rs2838808 chr21:46621106 A/G cg11663144 chr21:46675770 NA -0.41 -5.7 -0.3 2.67e-8 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs6840360 1.000 rs2007445 chr4:152600370 C/T cg09659197 chr4:152720779 NA 0.52 11.13 0.52 1.23e-24 Intelligence (multi-trait analysis); CRC cis rs7918232 0.941 rs7096505 chr10:27326999 T/C cg14442939 chr10:27389572 ANKRD26 0.81 8.82 0.44 6.79e-17 Breast cancer; CRC trans rs57221529 0.713 rs56328416 chr5:591138 G/A cg25482853 chr8:67687455 SGK3 1.19 14.24 0.62 3.37e-36 Lung disease severity in cystic fibrosis; CRC cis rs10924970 0.805 rs12030234 chr1:235517557 T/G cg26050004 chr1:235667680 B3GALNT2 0.42 5.89 0.31 9.36e-9 Asthma; CRC cis rs10991814 0.925 rs10991808 chr9:93946379 C/T cg14446406 chr9:93919335 NA -0.47 -6.31 -0.33 8.84e-10 Neutrophil percentage of granulocytes; CRC cis rs2302190 1.000 rs7207286 chr17:56514458 A/C cg25885038 chr17:56607967 SEPT4 0.43 6.93 0.36 2.27e-11 Vitamin D levels; CRC cis rs765787 0.530 rs12910270 chr15:45512086 G/A cg24006582 chr15:45444508 DUOX1 0.52 7.56 0.38 4.08e-13 Uric acid levels; CRC cis rs6840360 0.642 rs7680013 chr4:152409477 A/C cg09659197 chr4:152720779 NA 0.33 6.52 0.34 2.63e-10 Intelligence (multi-trait analysis); CRC cis rs2295359 0.892 rs2064689 chr1:67653010 G/A cg17031739 chr1:67600172 NA 0.41 6.33 0.33 8.2e-10 Psoriasis; CRC cis rs11122272 0.735 rs2790880 chr1:231534259 C/T cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.55 -8.04 -0.41 1.63e-14 Hemoglobin concentration; CRC cis rs9733 0.519 rs6700022 chr1:150670484 G/T cg10589385 chr1:150898437 SETDB1 -0.28 -6.06 -0.32 3.65e-9 Tonsillectomy; CRC cis rs7223966 1.000 rs56383601 chr17:61929968 A/C cg05941027 chr17:61774174 LIMD2 0.34 5.81 0.3 1.51e-8 Hip circumference adjusted for BMI;Body mass index; CRC cis rs9322193 0.923 rs9371199 chr6:150138662 A/T cg00933542 chr6:150070202 PCMT1 0.31 5.84 0.31 1.23e-8 Lung cancer; CRC cis rs661713 0.734 rs656214 chr6:90991488 T/C cg06866423 chr6:90926672 BACH2 0.38 5.63 0.3 3.97e-8 Hypothyroidism; CRC cis rs200986 1 rs200986 chr6:27824766 G/C cg10876282 chr6:28092338 ZSCAN16 0.43 5.78 0.3 1.77e-8 Autism spectrum disorder or schizophrenia; CRC cis rs17345786 0.861 rs17402964 chr3:101067945 C/T cg12386194 chr3:101231763 SENP7 0.55 7.11 0.36 7.26e-12 Colonoscopy-negative controls vs population controls; CRC cis rs3087591 0.960 rs2905794 chr17:29470002 G/A cg24425628 chr17:29625626 OMG;NF1 0.84 15.92 0.66 1.08e-42 Hip circumference; CRC cis rs7659604 1.000 rs6846232 chr4:122664805 A/G cg06713675 chr4:122721982 EXOSC9 -0.37 -6.05 -0.32 4e-9 Type 2 diabetes; CRC cis rs775227 0.574 rs79709668 chr3:113161265 G/A cg18753928 chr3:113234510 CCDC52 -0.57 -6.77 -0.35 6e-11 Dental caries; CRC cis rs17713451 0.593 rs17643028 chr7:151280487 C/A cg18404559 chr7:151322523 PRKAG2 -0.56 -6.42 -0.33 4.65e-10 Interleukin-4 levels; CRC cis rs3736485 0.934 rs4775956 chr15:51882638 G/C cg08986416 chr15:51914746 DMXL2 -0.46 -6.56 -0.34 2.11e-10 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs1506636 1.000 rs644958 chr7:123400873 C/T cg03229431 chr7:123269106 ASB15 0.73 11.58 0.54 3.15e-26 Plateletcrit;Platelet count; CRC cis rs798554 0.567 rs1182194 chr7:2868824 C/G cg19717773 chr7:2847554 GNA12 -0.43 -7.15 -0.37 5.75e-12 Height; CRC trans rs2727020 0.521 rs10839299 chr11:49573981 C/T cg15704280 chr7:45808275 SEPT13 -0.76 -10.06 -0.49 6.26e-21 Coronary artery disease; CRC cis rs9303280 0.901 rs7216389 chr17:38069949 C/T cg00129232 chr17:37814104 STARD3 0.46 7.28 0.37 2.45e-12 Self-reported allergy; CRC cis rs892961 0.806 rs35489990 chr17:75412312 T/C cg05865280 chr17:75406074 SEPT9 0.63 14.51 0.62 3.27e-37 Airflow obstruction; CRC cis rs9916302 0.706 rs12950186 chr17:37393395 A/C cg15445000 chr17:37608096 MED1 0.34 5.82 0.31 1.41e-8 Glomerular filtration rate (creatinine); CRC cis rs7666738 0.830 rs7682991 chr4:98982595 C/A cg05340658 chr4:99064831 C4orf37 0.6 9.41 0.46 8.57e-19 Colonoscopy-negative controls vs population controls; CRC cis rs1568889 1.000 rs1568889 chr11:28009463 A/G cg06544937 chr11:28130018 METT5D1;KIF18A 0.78 9.91 0.48 2.02e-20 Bipolar disorder; CRC cis rs9926296 0.546 rs6500442 chr16:89828862 T/C cg03388025 chr16:89894329 SPIRE2 0.42 8.19 0.41 5.68e-15 Vitiligo; CRC cis rs7191439 0.858 rs11076701 chr16:88774525 A/G cg02389323 chr16:88786976 FAM38A 0.9 8.17 0.41 6.82e-15 Plateletcrit; CRC cis rs7584330 0.740 rs7586312 chr2:238439389 G/A cg14458575 chr2:238380390 NA 0.58 9.68 0.47 1.17e-19 Prostate cancer; CRC cis rs73110464 0.505 rs2682296 chr12:53308265 G/A cg16329197 chr12:53359506 NA -0.39 -5.85 -0.31 1.18e-8 Cancer (pleiotropy); CRC cis rs6547741 1.000 rs4666007 chr2:27856495 T/C cg27432699 chr2:27873401 GPN1 0.73 13.07 0.58 1.02e-31 Oral cavity cancer; CRC cis rs1707322 0.648 rs4439382 chr1:46150805 C/T cg03146154 chr1:46216737 IPP 0.67 9.71 0.47 8.93e-20 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs13118159 0.527 rs1250119 chr4:1261336 G/A cg02475777 chr4:1388615 CRIPAK -0.5 -6.17 -0.32 2.02e-9 Longevity; CRC cis rs9443645 0.901 rs9352666 chr6:79572184 C/G cg05283184 chr6:79620031 NA -0.56 -9.02 -0.45 1.61e-17 Intelligence (multi-trait analysis); CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg05592363 chr5:78908495 PAPD4 0.39 6.24 0.33 1.32e-9 Obesity-related traits; CRC trans rs875971 0.545 rs6950988 chr7:65976415 C/T cg02869306 chr7:64672164 INTS4L1 -0.43 -6.25 -0.33 1.24e-9 Aortic root size; CRC cis rs1691799 0.867 rs1027401 chr12:66760892 C/G cg16791601 chr12:66731901 HELB -0.73 -12.68 -0.57 2.97e-30 White blood cell count (basophil); CRC cis rs367943 1.000 rs2248930 chr5:112811119 G/T cg12552261 chr5:112820674 MCC -0.49 -7.66 -0.39 2.06e-13 Type 2 diabetes; CRC cis rs10791323 0.569 rs2187450 chr11:133743792 A/G cg15485101 chr11:133734466 NA 0.43 8.11 0.41 9.96e-15 Childhood ear infection; CRC cis rs6496667 0.779 rs3213649 chr15:90999128 A/C cg04176472 chr15:90893244 GABARAPL3 0.59 8.32 0.42 2.4e-15 Rheumatoid arthritis; CRC trans rs7944735 0.517 rs7952205 chr11:48199227 A/G cg03929089 chr4:120376271 NA 0.6 6.12 0.32 2.7e-9 Intraocular pressure; CRC cis rs2985684 0.841 rs12894785 chr14:50049755 G/C cg23565292 chr14:50234668 KLHDC2 -0.43 -5.98 -0.31 5.95e-9 Carotid intima media thickness; CRC cis rs4363385 0.553 rs11580383 chr1:152942192 A/G cg25856811 chr1:152973957 SPRR3 -0.25 -6.59 -0.34 1.73e-10 Inflammatory skin disease; CRC cis rs1799949 0.965 rs33961729 chr17:41287924 C/A cg05368731 chr17:41323189 NBR1 0.65 9.59 0.47 2.27e-19 Menopause (age at onset); CRC cis rs4927850 1.000 rs10881564 chr3:195750326 C/T cg01181863 chr3:195395398 SDHAP2 -0.56 -7.78 -0.39 9.54e-14 Pancreatic cancer; CRC cis rs853679 0.723 rs9366718 chr6:28205502 A/T cg03623178 chr6:28175578 NA 0.75 7.82 0.4 7.2e-14 Depression; CRC cis rs13191362 0.935 rs13219926 chr6:163004213 T/C cg23758597 chr6:163146217 PARK2 -0.55 -6.13 -0.32 2.54e-9 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs6500602 0.701 rs4785969 chr16:4536934 A/T cg08645402 chr16:4508243 NA 0.56 8.44 0.42 1.01e-15 Schizophrenia; CRC cis rs2228479 0.850 rs17226966 chr16:89825338 A/G cg06656553 chr16:89960601 TCF25 -0.7 -5.76 -0.3 1.93e-8 Skin colour saturation; CRC cis rs1200821 0.535 rs1208784 chr10:37768433 A/G cg25427524 chr10:38739819 LOC399744 -0.57 -8.58 -0.43 3.89e-16 Hemostatic factors and hematological phenotypes; CRC cis rs644799 1.000 rs1784135 chr11:95531748 G/A cg25478527 chr11:95522999 CEP57;FAM76B 0.51 7.7 0.39 1.56e-13 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs6840360 0.554 rs6849111 chr4:152708874 T/C cg09659197 chr4:152720779 NA 0.41 8.4 0.42 1.32e-15 Intelligence (multi-trait analysis); CRC cis rs28386778 0.734 rs7210724 chr17:61799198 T/C cg25654072 chr17:61904446 PSMC5;FTSJ3 0.72 11.05 0.52 2.36e-24 Prudent dietary pattern; CRC cis rs910316 1.000 rs7145159 chr14:75583268 A/G cg03030879 chr14:75389066 RPS6KL1 -0.5 -8.01 -0.4 1.97e-14 Height; CRC cis rs9612 1.000 rs346545 chr19:44256386 T/C cg08581076 chr19:44259116 C19orf61 0.47 6.13 0.32 2.52e-9 Exhaled nitric oxide output; CRC cis rs6951245 1.000 rs28379681 chr7:1070539 C/T cg20603222 chr7:1096387 C7orf50;GPR146 -0.69 -8.1 -0.41 1.07e-14 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs6662572 0.737 rs72677518 chr1:46511118 T/C cg03123370 chr1:45965343 CCDC163P;MMACHC 0.47 6.12 0.32 2.7e-9 Blood protein levels; CRC cis rs4808199 0.948 rs2074300 chr19:19380996 G/T cg03709012 chr19:19516395 GATAD2A 0.99 11.89 0.55 2.31e-27 Nonalcoholic fatty liver disease; CRC cis rs9916302 0.904 rs11869109 chr17:37518205 G/T cg15445000 chr17:37608096 MED1 -0.43 -9.7 -0.47 9.71e-20 Glomerular filtration rate (creatinine); CRC cis rs1552244 0.572 rs6797536 chr3:10168802 C/T cg02579736 chr3:10068473 FANCD2;CIDECP -1.0 -11.72 -0.54 9.77e-27 Alzheimer's disease; CRC cis rs9914988 0.778 rs4794837 chr17:27110024 T/C cg20469991 chr17:27169893 C17orf63 -0.6 -7.27 -0.37 2.59e-12 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs12134245 0.742 rs17501381 chr1:92003919 A/G cg07090678 chr1:91966139 CDC7 0.41 6.71 0.35 8.27e-11 Breast cancer; CRC cis rs28386778 0.591 rs2584619 chr17:61913215 T/A cg06601766 chr17:61851465 DDX42;CCDC47 0.43 5.85 0.31 1.2e-8 Prudent dietary pattern; CRC cis rs13108904 0.934 rs13115173 chr4:1316824 T/C cg02018176 chr4:1364513 KIAA1530 0.46 7.56 0.38 4.04e-13 Obesity-related traits; CRC cis rs10504229 0.683 rs6995355 chr8:58113870 C/T cg21724239 chr8:58056113 NA 0.49 6.77 0.35 5.94e-11 Developmental language disorder (linguistic errors); CRC cis rs7208859 0.673 rs216409 chr17:28906269 C/T cg26176469 chr17:28951361 LRRC37B2 -0.51 -6.04 -0.32 4.22e-9 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs7927771 0.832 rs7105851 chr11:47383275 T/C cg18512352 chr11:47633146 NA 0.34 6.46 0.34 3.73e-10 Subjective well-being; CRC cis rs4969178 0.965 rs3744217 chr17:76400258 G/A cg20026190 chr17:76395443 PGS1 0.38 5.68 0.3 2.95e-8 HDL cholesterol levels; CRC cis rs9649213 0.574 rs7789440 chr7:97888798 G/T cg21770322 chr7:97807741 LMTK2 0.59 9.81 0.48 4.17e-20 Prostate cancer (SNP x SNP interaction); CRC cis rs6570726 0.791 rs10457788 chr6:145921136 T/A cg23711669 chr6:146136114 FBXO30 0.77 13.18 0.59 3.88e-32 Lobe attachment (rater-scored or self-reported); CRC cis rs9648716 1.000 rs6962239 chr7:140613919 C/T cg10747023 chr7:140774559 NA 0.47 6.1 0.32 2.98e-9 Type 2 diabetes; CRC cis rs7647973 0.593 rs58339610 chr3:49845006 T/A cg13072238 chr3:49761600 GMPPB 0.49 5.69 0.3 2.83e-8 Menarche (age at onset); CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg05942152 chr11:64902077 SYVN1 0.47 6.35 0.33 7e-10 Anxiety disorder; CRC cis rs8072100 0.666 rs9913503 chr17:45776330 T/G cg08085267 chr17:45401833 C17orf57 -0.45 -6.46 -0.34 3.67e-10 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs3020333 0.653 rs851983 chr6:152024415 A/G cg22157087 chr6:152012887 ESR1 0.48 7.22 0.37 3.57e-12 Total body bone mineral density; CRC cis rs270601 0.710 rs371709 chr5:131583240 A/G cg12564285 chr5:131593104 PDLIM4 0.55 9.71 0.47 9.47e-20 Acylcarnitine levels; CRC cis rs68170813 0.641 rs75639044 chr7:107092631 A/C cg02696742 chr7:106810147 HBP1 -0.57 -5.91 -0.31 8.42e-9 Coronary artery disease; CRC cis rs2180341 0.960 rs9401953 chr6:127687574 G/A cg27446573 chr6:127587934 RNF146 0.94 13.54 0.6 1.62e-33 Breast cancer; CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg21767656 chr15:63674112 CA12 -0.5 -6.3 -0.33 9.28e-10 Diisocyanate-induced asthma; CRC trans rs7395662 1.000 rs10769371 chr11:48531184 G/A cg21153622 chr11:89784906 NA -0.45 -7.11 -0.36 7.19e-12 HDL cholesterol; CRC trans rs853679 0.599 rs149949 chr6:28011516 T/C cg06606381 chr12:133084897 FBRSL1 -0.79 -7.6 -0.39 3.09e-13 Depression; CRC cis rs6920965 0.507 rs7754833 chr6:126190894 A/G cg05901451 chr6:126070800 HEY2 -0.42 -6.24 -0.33 1.39e-9 High light scatter reticulocyte count; CRC cis rs9649213 0.593 rs10953255 chr7:97923198 A/G cg24562669 chr7:97807699 LMTK2 0.43 7.19 0.37 4.41e-12 Prostate cancer (SNP x SNP interaction); CRC cis rs4713118 0.699 rs573179 chr6:27849676 C/A cg03623178 chr6:28175578 NA 0.8 10.53 0.5 1.5e-22 Parkinson's disease; CRC cis rs6921919 0.638 rs9468344 chr6:28309569 A/C cg03623178 chr6:28175578 NA 0.43 5.75 0.3 2.01e-8 Autism spectrum disorder or schizophrenia; CRC cis rs2315504 0.692 rs12602410 chr17:39017343 A/G cg06456531 chr17:38929184 KRT26 0.32 5.67 0.3 3.07e-8 Height; CRC cis rs7618915 0.547 rs35211965 chr3:52685305 C/G cg05573699 chr3:52720067 GNL3;PBRM1 -0.45 -6.32 -0.33 8.47e-10 Bipolar disorder; CRC cis rs758324 0.812 rs2133706 chr5:131165216 T/G cg25547332 chr5:131281432 NA 0.37 5.89 0.31 9.62e-9 Alzheimer's disease in APOE e4- carriers; CRC cis rs807669 0.524 rs11089258 chr22:19162276 C/T cg02655711 chr22:19163373 SLC25A1 0.59 9.78 0.47 5.4e-20 Metabolite levels; CRC cis rs6681460 1.000 rs10889641 chr1:67138367 C/T cg02459107 chr1:67143332 SGIP1 0.48 8.26 0.41 3.5e-15 Presence of antiphospholipid antibodies; CRC cis rs875971 0.638 rs801216 chr7:66011667 T/C cg18876405 chr7:65276391 NA -0.61 -10.95 -0.52 5.42e-24 Aortic root size; CRC cis rs2456568 0.548 rs7105031 chr11:93661207 C/T cg26875233 chr11:93583750 C11orf90 -0.36 -6.9 -0.36 2.65e-11 Response to serotonin reuptake inhibitors in major depressive disorder; CRC trans rs11250098 0.510 rs4840525 chr8:10765635 C/A cg08071915 chr8:12219732 FAM66A 0.34 6.09 0.32 3.15e-9 Morning vs. evening chronotype; CRC cis rs8177253 0.530 rs8177177 chr3:133463195 A/G cg11941060 chr3:133502564 NA -0.42 -6.97 -0.36 1.71e-11 Iron status biomarkers; CRC cis rs13118159 0.771 rs13117476 chr4:1334721 A/G cg16405210 chr4:1374714 KIAA1530 -0.44 -6.12 -0.32 2.72e-9 Longevity; CRC cis rs57221529 0.766 rs56278696 chr5:582669 A/G cg14541582 chr5:601475 NA -0.37 -7.17 -0.37 5.13e-12 Lung disease severity in cystic fibrosis; CRC cis rs801193 0.569 rs13242290 chr7:66121885 G/A cg18876405 chr7:65276391 NA -0.5 -7.98 -0.4 2.47e-14 Aortic root size; CRC cis rs694739 1.000 rs694739 chr11:64097233 A/G cg02228329 chr11:64053129 BAD;GPR137 0.6 8.77 0.44 9.67e-17 Alopecia areata;Crohn's disease;Psoriasis vulgaris; CRC cis rs3857067 0.806 rs7654919 chr4:95136164 C/T cg11021082 chr4:95130006 SMARCAD1 -0.52 -8.19 -0.41 5.99e-15 QT interval; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg24105797 chr17:74553636 SNORD1C 0.46 6.26 0.33 1.21e-9 Response to antipsychotic treatment; CRC cis rs2535633 0.594 rs2581789 chr3:53096230 C/T cg05573699 chr3:52720067 GNL3;PBRM1 0.41 5.92 0.31 7.9e-9 Body mass index; CRC trans rs9341835 0.608 rs2076874 chr6:64153691 G/A cg13657004 chr13:50234944 EBPL -0.37 -6.42 -0.33 4.86e-10 Schizophrenia; CRC cis rs8077889 0.917 rs8081646 chr17:41893360 T/C cg26893861 chr17:41843967 DUSP3 0.88 11.79 0.55 5.3e-27 Triglycerides; CRC cis rs9768139 0.733 rs13309408 chr7:158122261 C/T cg06219351 chr7:158114137 PTPRN2 -0.54 -8.19 -0.41 5.81e-15 Calcium levels; CRC cis rs11098499 0.874 rs7661020 chr4:120106982 T/C cg24375607 chr4:120327624 NA 0.47 7.18 0.37 4.76e-12 Corneal astigmatism; CRC cis rs1832871 0.711 rs12525147 chr6:158683509 A/G cg07165851 chr6:158734300 TULP4 0.59 7.37 0.38 1.41e-12 Height; CRC cis rs6502050 0.787 rs7222326 chr17:80057272 T/C cg22110888 chr17:80059540 CCDC57 -0.44 -6.83 -0.35 4.06e-11 Life satisfaction; CRC cis rs9435341 0.929 rs1730865 chr1:107605611 A/C cg09367891 chr1:107599246 PRMT6 0.67 9.92 0.48 1.8899999999999998e-20 Facial morphology (factor 21, depth of nasal alae); CRC cis rs56104184 0.775 rs17272707 chr19:49404535 T/G cg21252483 chr19:49399788 TULP2 -0.43 -6.78 -0.35 5.71e-11 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; CRC trans rs7395662 0.929 rs12363679 chr11:48556023 G/C cg21153622 chr11:89784906 NA -0.45 -7.24 -0.37 3.25e-12 HDL cholesterol; CRC trans rs9858542 0.953 rs9841110 chr3:49492481 C/G cg21582582 chr3:182698605 DCUN1D1 -0.51 -6.47 -0.34 3.47e-10 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs7909074 0.691 rs11239274 chr10:45393219 A/C cg05187965 chr10:45406764 TMEM72 0.31 6.7 0.35 8.88e-11 Mean corpuscular volume; CRC cis rs9311474 0.607 rs34005367 chr3:52558904 A/T cg11645453 chr3:52864694 ITIH4 0.32 5.74 0.3 2.15e-8 Electroencephalogram traits; CRC cis rs1577917 0.633 rs7770835 chr6:86608907 A/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.45 -5.85 -0.31 1.19e-8 Response to antipsychotic treatment; CRC cis rs11148252 0.538 rs9526842 chr13:52727723 T/G cg00495681 chr13:53174319 NA 0.64 9.57 0.47 2.72e-19 Lewy body disease; CRC cis rs4631830 0.869 rs11006207 chr10:51538176 T/C cg20129853 chr10:51489980 NA -0.36 -5.92 -0.31 8.09e-9 Prostate-specific antigen levels; CRC cis rs875971 0.545 rs67688847 chr7:65626051 G/A cg18876405 chr7:65276391 NA 0.44 6.12 0.32 2.67e-9 Aortic root size; CRC cis rs7937682 0.793 rs7130440 chr11:111417779 A/G cg19812747 chr11:111475976 SIK2 0.43 6.42 0.33 4.79e-10 Primary sclerosing cholangitis; CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg27304813 chr3:120068385 LRRC58 -0.49 -6.01 -0.31 5.03e-9 Diisocyanate-induced asthma; CRC cis rs6952407 1 rs6952407 chr7:66045512 A/G cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.44 -6.36 -0.33 6.88e-10 Cotinine glucuronidation; CRC cis rs6121246 0.559 rs6060952 chr20:30382108 T/G cg13852791 chr20:30311386 BCL2L1 0.76 14.72 0.63 4.76e-38 Mean corpuscular hemoglobin; CRC cis rs7909074 0.798 rs914699 chr10:45377066 A/C cg04218760 chr10:45406644 TMEM72 -0.34 -9.67 -0.47 1.2e-19 Mean corpuscular volume; CRC cis rs4363385 0.818 rs11205167 chr1:152989727 T/G cg25856811 chr1:152973957 SPRR3 -0.26 -7.13 -0.37 6.43e-12 Inflammatory skin disease; CRC cis rs116095464 0.558 rs10057492 chr5:239503 T/C cg22857025 chr5:266934 NA -1.25 -16.75 -0.68 5.7e-46 Breast cancer; CRC cis rs9914988 0.673 rs9890212 chr17:27169890 G/C cg20469991 chr17:27169893 C17orf63 -0.55 -6.67 -0.35 1.1e-10 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs8177253 1.000 rs1525892 chr3:133484712 C/T cg01448562 chr3:133502909 NA -0.56 -9.6 -0.47 2.17e-19 Iron status biomarkers; CRC cis rs769267 0.931 rs15622 chr19:19468734 G/A cg01262667 chr19:19385393 TM6SF2 -0.37 -6.12 -0.32 2.69e-9 Tonsillectomy; CRC cis rs3741404 0.757 rs2282492 chr11:63918589 A/G cg05016508 chr11:63871570 FLRT1;MACROD1 0.44 6.53 0.34 2.5e-10 Platelet count; CRC trans rs17685 0.753 rs6951808 chr7:75772413 A/G cg19862616 chr7:65841803 NCRNA00174 0.98 18.08 0.71 3.12e-51 Coffee consumption;Coffee consumption (cups per day); CRC cis rs12142240 0.698 rs966907 chr1:46817125 C/G cg14993813 chr1:46806288 NSUN4 -0.5 -6.4 -0.33 5.38e-10 Menopause (age at onset); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg03264960 chr2:187350743 ZC3H15 0.44 6.07 0.32 3.46e-9 Response to antipsychotic treatment; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg13559478 chr7:148959298 ZNF783 0.45 6.16 0.32 2.08e-9 Anxiety disorder; CRC cis rs10489202 0.632 rs202265 chr1:167990231 G/C cg24449463 chr1:168025552 DCAF6 -0.6 -9.16 -0.45 5.81e-18 Schizophrenia; CRC cis rs11785400 0.731 rs4644221 chr8:143736984 C/T cg24634471 chr8:143751801 JRK -0.43 -5.91 -0.31 8.39e-9 Schizophrenia; CRC cis rs6761276 0.837 rs11887823 chr2:113835311 T/A cg09040174 chr2:113837401 NA 0.64 10.17 0.49 2.58e-21 Protein quantitative trait loci; CRC cis rs1448094 0.512 rs6539932 chr12:86247497 T/C cg25456477 chr12:86230367 RASSF9 0.34 5.93 0.31 7.72e-9 Major depressive disorder; CRC cis rs1153858 1.000 rs7163720 chr15:45639374 G/A cg10760299 chr15:45669010 GATM 0.5 7.97 0.4 2.72e-14 Homoarginine levels; CRC cis rs2836974 0.865 rs34778912 chr21:40667037 T/G cg11890956 chr21:40555474 PSMG1 1.07 17.99 0.7 6.94e-51 Cognitive function; CRC cis rs2179367 0.600 rs11155654 chr6:149763137 G/A cg11245181 chr6:149772854 ZC3H12D -0.41 -5.77 -0.3 1.85e-8 Dupuytren's disease; CRC cis rs10256972 0.706 rs12701969 chr7:1121849 A/G cg07308232 chr7:1071921 C7orf50 -0.47 -6.25 -0.33 1.3e-9 Longevity;Endometriosis; CRC cis rs868943 0.743 rs10457303 chr6:116413841 C/T cg18764771 chr6:116381957 FRK 0.25 6.11 0.32 2.81e-9 Total cholesterol levels; CRC cis rs954108 0.522 rs7983818 chr13:29383182 A/C cg05095123 chr13:29393749 NA -0.33 -6.05 -0.32 3.97e-9 Obesity-related traits; CRC cis rs629535 0.862 rs638412 chr8:70047690 C/T cg26132723 chr8:70041827 NA 0.35 5.72 0.3 2.41e-8 Dupuytren's disease; CRC cis rs7147624 1.000 rs2411821 chr14:65896914 G/T cg03016385 chr14:66212404 NA -0.98 -10.21 -0.49 1.99e-21 Chronic obstructive pulmonary disease-related biomarkers; CRC trans rs4263408 0.934 rs9683743 chr4:39703194 A/C cg01008834 chr1:150207620 ANP32E -0.43 -6.39 -0.33 5.73e-10 Plasma amyloid beta peptide concentrations (ABx-40); CRC cis rs2811415 0.597 rs9814296 chr3:127732028 G/A cg13719885 chr3:127795394 NA -0.39 -5.96 -0.31 6.45e-9 Lung function (FEV1/FVC); CRC cis rs11190604 1.000 rs2489037 chr10:102319918 A/G cg16342193 chr10:102329863 NA 0.37 5.95 0.31 6.84e-9 Palmitoleic acid (16:1n-7) levels; CRC cis rs7552404 0.924 rs2275378 chr1:76198436 T/C cg10523679 chr1:76189770 ACADM 0.93 14.38 0.62 1.01e-36 Blood metabolite levels;Acylcarnitine levels; CRC cis rs4563143 0.634 rs113736470 chr19:29240125 G/A cg12667521 chr19:29218732 NA 0.51 8.03 0.4 1.79e-14 Methadone dose in opioid dependence; CRC cis rs9916302 0.904 rs34363096 chr17:37594294 G/A cg00129232 chr17:37814104 STARD3 -0.54 -8.1 -0.41 1.06e-14 Glomerular filtration rate (creatinine); CRC cis rs9547692 1.000 rs9531993 chr13:37475197 G/C cg01493522 chr13:37497338 NA -0.52 -7.28 -0.37 2.45e-12 Coronary artery disease; CRC cis rs11098499 0.604 rs2389886 chr4:120570422 C/T cg09307838 chr4:120376055 NA 0.67 9.89 0.48 2.28e-20 Corneal astigmatism; CRC cis rs10782582 0.593 rs6704444 chr1:76205108 T/C cg03433033 chr1:76189801 ACADM -0.46 -6.73 -0.35 7.38e-11 Daytime sleep phenotypes; CRC cis rs9400271 0.632 rs6930844 chr6:109590286 C/A cg01475377 chr6:109611718 NA -0.35 -6.07 -0.32 3.59e-9 Sum neutrophil eosinophil counts;Sum basophil neutrophil counts;White blood cell count;Neutrophil count;Myeloid white cell count;Granulocyte count; CRC cis rs3750082 0.817 rs4723221 chr7:32954207 C/T cg05721444 chr7:32995514 FKBP9 -0.52 -7.88 -0.4 4.91e-14 Glomerular filtration rate (creatinine); CRC cis rs240110 0.515 rs12530388 chr6:101329173 A/C cg09795085 chr6:101329169 ASCC3 0.49 6.97 0.36 1.79e-11 Neuroticism; CRC cis rs4363385 0.782 rs310105 chr1:153022253 A/G cg25856811 chr1:152973957 SPRR3 -0.27 -7.49 -0.38 6.4e-13 Inflammatory skin disease; CRC cis rs6912958 1.000 rs6912958 chr6:88133315 G/A cg04972856 chr6:88032051 C6orf162;GJB7 -0.33 -5.91 -0.31 8.4e-9 Monocyte percentage of white cells; CRC trans rs877282 0.797 rs35927768 chr10:753095 T/C cg22713356 chr15:30763199 NA 1.18 13.47 0.6 3.17e-33 Uric acid levels; CRC cis rs7932354 0.528 rs10466478 chr11:47162604 A/C cg19486271 chr11:47235900 DDB2 -0.47 -7.27 -0.37 2.72e-12 Bone mineral density (hip);Bone mineral density; CRC cis rs9549367 0.762 rs9549694 chr13:113870510 G/A cg00898013 chr13:113819073 PROZ -0.4 -5.84 -0.31 1.26e-8 Platelet distribution width; CRC cis rs7849270 0.959 rs913276 chr9:131917164 C/T cg13538475 chr9:131942899 NA -0.3 -5.78 -0.3 1.73e-8 Blood metabolite ratios; CRC cis rs28386778 0.897 rs8069969 chr17:61822223 T/G cg23090583 chr17:61904693 PSMC5;FTSJ3 1.04 20.57 0.75 5.01e-61 Prudent dietary pattern; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg23187101 chr19:1812290 ATP8B3 0.37 6.27 0.33 1.11e-9 Liver disease severity in Alagille syndrome; CRC cis rs2976388 0.632 rs2585139 chr8:143808175 C/G cg05569086 chr8:143859399 LYNX1 0.39 6.64 0.34 1.3100000000000001e-10 Urinary tract infection frequency; CRC cis rs9322193 0.961 rs9027 chr6:149916057 T/A cg07701084 chr6:150067640 NUP43 0.45 6.41 0.33 4.9e-10 Lung cancer; CRC cis rs853679 0.517 rs6932109 chr6:28078303 A/G cg02631126 chr6:28058918 ZSCAN12L1 -0.27 -5.85 -0.31 1.18e-8 Depression; CRC cis rs6500602 0.702 rs6500606 chr16:4502514 A/G cg08645402 chr16:4508243 NA -0.59 -10.3 -0.49 9.49e-22 Schizophrenia; CRC cis rs6685188 0.920 rs6676110 chr1:205662977 G/A cg07157834 chr1:205819609 PM20D1 -0.44 -6.15 -0.32 2.21e-9 White blood cell count (basophil);Basophil percentage of white cells; CRC trans rs2303319 0.504 rs56009150 chr2:162598582 T/C cg12500891 chr11:57225987 NA -0.66 -6.1 -0.32 2.98e-9 Cognitive function; CRC cis rs2404602 0.647 rs12440511 chr15:76993135 A/G cg03037974 chr15:76606532 NA -0.5 -7.36 -0.38 1.46e-12 Blood metabolite levels; CRC cis rs4711336 1.000 rs764752 chr6:33658066 G/C cg14003231 chr6:33640908 ITPR3 0.51 8.22 0.41 4.71e-15 Height; CRC cis rs1580019 0.587 rs9638880 chr7:32552401 A/G cg06627557 chr7:32535165 LSM5;AVL9 0.96 18.41 0.71 1.56e-52 Cognitive ability; CRC cis rs4073416 0.542 rs2300864 chr14:66119800 A/G cg03016385 chr14:66212404 NA -0.45 -6.14 -0.32 2.37e-9 N-glycan levels; CRC cis rs9894429 0.966 rs6565601 chr17:79580173 C/T cg21984481 chr17:79567631 NPLOC4 -0.53 -9.8 -0.48 4.52e-20 Eye color traits; CRC cis rs875971 0.862 rs11984115 chr7:65773859 C/T cg18252515 chr7:66147081 NA 0.41 5.73 0.3 2.26e-8 Aortic root size; CRC cis rs7044106 0.762 rs1547268 chr9:123408688 T/C cg14255062 chr9:123606675 PSMD5;LOC253039 0.44 6.28 0.33 1.07e-9 Hip circumference adjusted for BMI; CRC cis rs6502050 0.765 rs6502074 chr17:80121776 T/C cg22110888 chr17:80059540 CCDC57 0.41 6.46 0.34 3.71e-10 Life satisfaction; CRC cis rs7044106 0.762 rs4837789 chr9:123426256 G/A cg14255062 chr9:123606675 PSMD5;LOC253039 0.44 6.48 0.34 3.39e-10 Hip circumference adjusted for BMI; CRC cis rs2762353 0.595 rs12200838 chr6:25753603 C/T cg03517284 chr6:25882590 NA 0.74 10.39 0.5 4.59e-22 Blood metabolite levels; CRC cis rs7618915 0.547 rs2286800 chr3:52778051 C/T cg10802521 chr3:52805072 NEK4 -0.57 -8.77 -0.44 1.01e-16 Bipolar disorder; CRC trans rs2303319 0.504 rs56152608 chr2:162283469 G/A cg04145477 chr6:107077629 RTN4IP1;QRSL1 -0.86 -6.37 -0.33 6.37e-10 Cognitive function; CRC cis rs9549260 0.755 rs9577091 chr13:41227865 G/A cg21288729 chr13:41239152 FOXO1 0.49 7.66 0.39 2.05e-13 Red blood cell count; CRC cis rs644799 1.000 rs11021319 chr11:95523123 C/G cg03916912 chr11:95522834 CEP57;FAM76B 0.96 18.3 0.71 4.39e-52 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC trans rs12478296 0.901 rs7423119 chr2:243005488 T/A cg18288967 chr1:45987694 PRDX1 0.63 7.37 0.38 1.42e-12 Obesity-related traits; CRC trans rs4332037 0.539 rs55988458 chr7:2059761 G/A cg11693508 chr17:37793320 STARD3 0.6 7.04 0.36 1.15e-11 Bipolar disorder; CRC cis rs6952808 0.692 rs11765549 chr7:2027311 G/T cg00106254 chr7:1943704 MAD1L1 -0.57 -8.21 -0.41 5.2e-15 Bipolar disorder and schizophrenia; CRC cis rs78456975 0.506 rs13384333 chr2:1555531 A/C cg12573674 chr2:1569213 NA -0.74 -9.56 -0.47 2.93e-19 Placebo response in major depressive disorder (% change in symptom score); CRC cis rs6940116 1 rs6940116 chr6:27708732 A/G cg06470822 chr6:28175283 NA 0.59 5.98 0.31 5.97e-9 Intelligence (multi-trait analysis);Autism spectrum disorder or schizophrenia; CRC cis rs7615952 0.599 rs2270986 chr3:125701099 T/C cg02772935 chr3:125709198 NA -0.49 -5.73 -0.3 2.27e-8 Blood pressure (smoking interaction); CRC cis rs79349575 0.715 rs62075844 chr17:47002389 G/A cg22482690 chr17:47019901 SNF8 0.48 8.03 0.41 1.7e-14 Type 2 diabetes; CRC cis rs561341 0.941 rs72825746 chr17:30364610 G/A cg23018236 chr17:30244563 NA -0.68 -8.14 -0.41 8.44e-15 Hip circumference adjusted for BMI; CRC cis rs1862618 0.671 rs2591966 chr5:56233688 T/G cg03609598 chr5:56110824 MAP3K1 0.54 7.39 0.38 1.22e-12 Initial pursuit acceleration; CRC cis rs7726839 0.526 rs11960158 chr5:568665 C/T cg16447950 chr5:562315 NA -0.85 -13.05 -0.58 1.17e-31 Obesity-related traits; CRC cis rs798554 0.680 rs1713912 chr7:2895784 C/A cg04166393 chr7:2884313 GNA12 0.5 6.85 0.35 3.68e-11 Height; CRC cis rs881375 0.967 rs10739580 chr9:123695282 C/T cg09419670 chr9:123605666 PSMD5;LOC253039 0.57 8.45 0.42 9.68e-16 Rheumatoid arthritis; CRC trans rs11098499 0.722 rs10025925 chr4:120271744 A/T cg25214090 chr10:38739885 LOC399744 0.53 8.51 0.42 6.28e-16 Corneal astigmatism; CRC cis rs9513593 1.000 rs7323390 chr13:99997968 A/G cg21788972 chr13:99853209 UBAC2 0.46 5.98 0.31 5.9e-9 Psoriasis; CRC cis rs6570726 0.791 rs9497357 chr6:145912888 G/A cg13319975 chr6:146136371 FBXO30 -0.43 -6.27 -0.33 1.12e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs12900413 0.959 rs12902793 chr15:90304402 G/A cg24249390 chr15:90295951 MESP1 -0.63 -9.13 -0.45 6.91e-18 Coronary artery aneurysm in Kawasaki disease; CRC cis rs4713118 0.629 rs203890 chr6:28022248 T/C cg12273811 chr6:28175739 NA 0.63 8.52 0.43 5.94e-16 Parkinson's disease; CRC cis rs7772486 0.743 rs2092262 chr6:146037105 C/T cg13319975 chr6:146136371 FBXO30 0.4 5.89 0.31 9.62e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs2380220 0.576 rs7751219 chr6:96018915 G/A cg15832292 chr6:96025679 MANEA 0.61 6.66 0.34 1.17e-10 Behavioural disinhibition (generation interaction); CRC cis rs12216125 0.549 rs9358905 chr6:26077839 T/A cg17691542 chr6:26056736 HIST1H1C 0.55 8.42 0.42 1.22e-15 Iron status biomarkers; CRC cis rs7312933 0.703 rs2406567 chr12:42551479 G/C cg19980929 chr12:42632907 YAF2 0.44 6.53 0.34 2.47e-10 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CRC cis rs597539 0.552 rs6591361 chr11:68719284 T/C cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.77 12.49 0.57 1.39e-29 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs34375054 0.624 rs73233307 chr12:125675873 G/C cg25124228 chr12:125621409 AACS -0.52 -6.72 -0.35 8.21e-11 Post bronchodilator FEV1/FVC ratio; CRC cis rs921968 0.541 rs6710383 chr2:219359685 T/G cg02176678 chr2:219576539 TTLL4 0.54 8.69 0.43 1.78e-16 Mean corpuscular hemoglobin concentration; CRC cis rs529866 0.519 rs4451969 chr16:11383519 A/G cg00044050 chr16:11439710 C16orf75 -0.43 -6.13 -0.32 2.55e-9 Crohn's disease;Inflammatory bowel disease; CRC cis rs2996428 0.667 rs113120570 chr1:3770450 G/C cg17848003 chr1:3704513 LRRC47 0.39 5.72 0.3 2.38e-8 Red cell distribution width; CRC trans rs9291683 0.595 rs3733585 chr4:10036339 A/G cg26043149 chr18:55253948 FECH 0.53 8.17 0.41 6.8e-15 Bone mineral density; CRC cis rs2949837 0.581 rs1543270 chr7:46006323 C/T cg23193639 chr7:45961078 IGFBP3 0.4 6.59 0.34 1.76e-10 Sitting height ratio; CRC cis rs6032067 0.929 rs11699850 chr20:43809049 T/C cg10761708 chr20:43804764 PI3 0.51 5.89 0.31 9.53e-9 Blood protein levels; CRC cis rs5769765 0.862 rs9616380 chr22:50312225 T/C cg22709217 chr22:50311962 ALG12;CRELD2 -1.12 -18.26 -0.71 6.49e-52 Schizophrenia; CRC cis rs4713118 0.824 rs13211701 chr6:27750079 T/C cg03623178 chr6:28175578 NA 0.7 9.33 0.46 1.61e-18 Parkinson's disease; CRC cis rs2075371 0.796 rs10954440 chr7:134005657 C/T cg11752832 chr7:134001865 SLC35B4 0.42 6.41 0.33 4.96e-10 Mean platelet volume; CRC trans rs3794271 0.706 rs9971816 chr12:20826911 C/T cg19445734 chr2:55566679 CCDC88A 0.44 6.31 0.33 9.27e-10 Response to TNF-alpha inhibitors in rheumatoid arthritis; CRC cis rs1552244 0.882 rs13075842 chr3:10055813 A/C cg02579736 chr3:10068473 FANCD2;CIDECP 0.97 12.42 0.57 2.56e-29 Alzheimer's disease; CRC cis rs9469890 0.604 rs77186075 chr6:34504478 C/T cg17674042 chr6:34482479 PACSIN1 -0.66 -7.76 -0.39 1.1e-13 Pubertal anthropometrics;Coronary artery disease; CRC cis rs6502050 0.835 rs7503111 chr17:80101587 A/T cg22110888 chr17:80059540 CCDC57 0.4 6.44 0.33 4.17e-10 Life satisfaction; CRC trans rs561341 0.882 rs28649357 chr17:30367190 A/G cg27661571 chr11:113659931 NA -0.71 -8.73 -0.43 1.33e-16 Hip circumference adjusted for BMI; CRC cis rs3096299 0.503 rs4785677 chr16:89555101 A/G cg02187348 chr16:89574699 SPG7 0.42 6.13 0.32 2.54e-9 Multiple myeloma (IgH translocation); CRC cis rs67311347 0.911 rs9863737 chr3:40439836 C/T cg09455208 chr3:40491958 NA 0.46 8.66 0.43 2.2e-16 Renal cell carcinoma; CRC cis rs7044106 0.708 rs991121 chr9:123370345 C/G cg14255062 chr9:123606675 PSMD5;LOC253039 0.41 6.29 0.33 9.89e-10 Hip circumference adjusted for BMI; CRC cis rs35740288 0.545 rs12916187 chr15:86326124 A/C cg20737812 chr15:86336631 KLHL25 -0.48 -7.15 -0.37 5.63e-12 Eosinophil percentage of white cells;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes; CRC cis rs561341 0.941 rs4525554 chr17:30312819 T/C cg00745463 chr17:30367425 LRRC37B -0.89 -9.87 -0.48 2.65e-20 Hip circumference adjusted for BMI; CRC cis rs9811920 0.809 rs4928151 chr3:99767553 A/C cg07805332 chr3:99536008 MIR548G;C3orf26 0.41 6.39 0.33 5.69e-10 Axial length; CRC cis rs34864796 0.547 rs200476 chr6:27768348 A/T cg20933634 chr6:27740509 NA 0.61 7.88 0.4 4.77e-14 Lung function (FEV1);Lung function (FEV1/FVC);Lung function (FVC); CRC trans rs1499614 1.000 rs1882655 chr7:66147057 T/C cg10756647 chr7:56101905 PSPH -0.78 -8.17 -0.41 6.58e-15 Gout; CRC cis rs2878628 0.650 rs56098033 chr3:52758571 T/A cg18099408 chr3:52552593 STAB1 -0.46 -7.76 -0.39 1.07e-13 Intelligence (multi-trait analysis); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg25018357 chr1:26490989 NA 0.41 7.06 0.36 9.67e-12 Liver disease severity in Alagille syndrome; CRC cis rs2228479 0.717 rs9282682 chr16:89805794 A/G cg06558623 chr16:89946397 TCF25 0.93 9.52 0.46 4.01e-19 Skin colour saturation; CRC cis rs1448094 0.527 rs59445394 chr12:86237843 C/T cg19622623 chr12:86230825 RASSF9 -0.41 -6.57 -0.34 1.94e-10 Major depressive disorder; CRC cis rs9611565 0.802 rs132916 chr22:41806768 C/G cg06634786 chr22:41940651 POLR3H 0.56 6.82 0.35 4.5e-11 Vitiligo; CRC cis rs3857067 0.901 rs965807 chr4:95045567 G/T cg11021082 chr4:95130006 SMARCAD1 -0.39 -5.8 -0.3 1.54e-8 QT interval; CRC cis rs6502050 0.805 rs11077970 chr17:80085916 C/T cg02741985 chr17:80059408 CCDC57 -0.43 -7.14 -0.37 5.98e-12 Life satisfaction; CRC cis rs875971 0.522 rs56028712 chr7:65466565 C/T cg02869306 chr7:64672164 INTS4L1 -0.36 -5.89 -0.31 9.51e-9 Aortic root size; CRC cis rs12760731 0.582 rs34016755 chr1:178517005 G/C cg00404053 chr1:178313656 RASAL2 0.7 7.82 0.4 7.33e-14 Obesity-related traits; CRC cis rs2404602 0.716 rs12917430 chr15:76674360 T/C cg00316803 chr15:76480434 C15orf27 -0.35 -5.74 -0.3 2.21e-8 Blood metabolite levels; CRC cis rs4713118 0.662 rs9468276 chr6:28027688 A/C cg15786705 chr6:28176104 NA 0.69 9.22 0.45 3.53e-18 Parkinson's disease; CRC cis rs6540559 0.673 rs6540560 chr1:209982073 A/G cg23283495 chr1:209979779 IRF6 -0.43 -6.3 -0.33 9.38e-10 Cleft lip with or without cleft palate; CRC cis rs4665809 0.887 rs4665825 chr2:26333100 A/G cg27170947 chr2:26402098 FAM59B -0.46 -6.13 -0.32 2.58e-9 Gut microbiome composition (summer); CRC cis rs7618501 0.635 rs7635002 chr3:49989155 T/G cg24308560 chr3:49941425 MST1R -0.51 -8.21 -0.41 5.03e-15 Intelligence (multi-trait analysis); CRC cis rs7613875 0.600 rs2624848 chr3:50165101 T/C cg24308560 chr3:49941425 MST1R 0.41 6.13 0.32 2.56e-9 Body mass index; CRC cis rs2070488 0.662 rs7652475 chr3:38481341 C/T cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.58 8.79 0.44 8.58e-17 Electrocardiographic conduction measures; CRC cis rs9457247 0.765 rs9459849 chr6:167444160 G/T cg23791538 chr6:167370224 RNASET2 -0.38 -5.7 -0.3 2.63e-8 Crohn's disease; CRC cis rs7539624 0.588 rs7414311 chr1:223901497 A/G cg10100437 chr1:223903862 CAPN2 0.45 6.33 0.33 8.07e-10 Schizophrenia; CRC cis rs12410462 0.681 rs12401677 chr1:227608577 T/C cg23173402 chr1:227635558 NA 0.8 8.37 0.42 1.72e-15 Major depressive disorder; CRC cis rs597539 0.690 rs635529 chr11:68626294 C/T cg21963583 chr11:68658836 MRPL21 0.63 10.94 0.52 5.56e-24 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs780096 0.546 rs6547626 chr2:27646770 C/T cg17158414 chr2:27665306 KRTCAP3 -0.29 -6.25 -0.33 1.28e-9 Total body bone mineral density; CRC cis rs67478160 0.643 rs12880821 chr14:104276049 C/T cg08213375 chr14:104286397 PPP1R13B 0.62 12.41 0.56 2.91e-29 Schizophrenia; CRC cis rs9443645 0.901 rs1567167 chr6:79553827 C/T cg05283184 chr6:79620031 NA -0.56 -9.02 -0.45 1.61e-17 Intelligence (multi-trait analysis); CRC trans rs7395662 1.000 rs12420372 chr11:48497603 A/C cg21153622 chr11:89784906 NA 0.48 7.57 0.39 3.84e-13 HDL cholesterol; CRC cis rs2243480 1.000 rs316330 chr7:65605372 C/A cg12463550 chr7:65579703 CRCP 0.7 6.46 0.34 3.79e-10 Diabetic kidney disease; CRC cis rs854765 0.547 rs9896837 chr17:17924868 A/G cg09796270 chr17:17721594 SREBF1 0.49 8.33 0.42 2.15e-15 Total body bone mineral density; CRC cis rs3785574 0.962 rs2247435 chr17:61892862 G/A cg11494091 chr17:61959527 GH2 0.37 5.66 0.3 3.34e-8 Height; CRC cis rs17155006 0.664 rs401487 chr7:107743409 A/G cg05962710 chr7:107745446 LAMB4 -0.4 -7.19 -0.37 4.29e-12 Pneumococcal bacteremia; CRC trans rs58106596 0.747 rs10166046 chr2:232560984 C/T cg01370599 chr3:116745421 NA -0.46 -6.43 -0.33 4.48e-10 White blood cell count;Lymphocyte counts; CRC cis rs4713118 0.824 rs742046 chr6:27739254 A/G cg25164649 chr6:28176230 NA 0.58 7.72 0.39 1.39e-13 Parkinson's disease; CRC cis rs765787 0.530 rs2413782 chr15:45538490 A/C cg24006582 chr15:45444508 DUOX1 -0.57 -8.63 -0.43 2.62e-16 Uric acid levels; CRC cis rs155076 0.711 rs4770131 chr13:21897468 A/G cg21970626 chr13:21893289 NA -0.44 -6.68 -0.35 1.02e-10 White matter hyperintensity burden; CRC cis rs2777491 0.915 rs7165675 chr15:41614704 T/C cg18705301 chr15:41695430 NDUFAF1 -0.69 -11.44 -0.53 9.35e-26 Ulcerative colitis; CRC cis rs9768139 0.708 rs896780 chr7:158113972 C/T cg24154853 chr7:158122151 PTPRN2 0.58 9.47 0.46 5.85e-19 Calcium levels; CRC trans rs7267979 1.000 rs2257420 chr20:25275890 C/A cg17903999 chr18:56338584 MALT1 -0.41 -6.86 -0.35 3.39e-11 Liver enzyme levels (alkaline phosphatase); CRC cis rs8180040 0.615 rs13062681 chr3:47021124 A/G cg02527881 chr3:46936655 PTH1R -0.42 -7.82 -0.4 7.38e-14 Colorectal cancer; CRC cis rs597539 0.652 rs674654 chr11:68698762 G/T cg06028808 chr11:68637592 NA 0.38 6.03 0.32 4.4e-9 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC trans rs116095464 0.764 rs10069197 chr5:230822 G/C cg00938859 chr5:1591904 SDHAP3 0.72 7.97 0.4 2.65e-14 Breast cancer; CRC cis rs694739 0.628 rs10897487 chr11:64140704 C/T cg23796481 chr11:64053134 BAD;GPR137 0.48 6.65 0.34 1.21e-10 Alopecia areata;Crohn's disease;Psoriasis vulgaris; CRC cis rs4665809 0.590 rs7260 chr2:26413917 C/T cg08067268 chr2:26466485 HADHB;HADHA -0.65 -8.57 -0.43 4.07e-16 Gut microbiome composition (summer); CRC cis rs4731207 0.698 rs4279518 chr7:124528086 G/T cg23710748 chr7:124431027 NA -0.38 -6.06 -0.32 3.65e-9 Cutaneous malignant melanoma; CRC cis rs875971 1.000 rs778710 chr7:65854834 T/C cg11764359 chr7:65958608 NA 0.61 9.95 0.48 1.41e-20 Aortic root size; CRC cis rs728616 1.000 rs12768613 chr10:81916566 C/T cg05935833 chr10:81318306 SFTPA2 -0.48 -5.89 -0.31 9.63e-9 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs8060686 0.545 rs8056649 chr16:68260083 A/G cg26727032 chr16:67993705 SLC12A4 0.53 6.72 0.35 7.81e-11 HDL cholesterol;Metabolic syndrome; CRC cis rs1570884 0.516 rs9526580 chr13:50164023 C/G cg02321871 chr13:50159138 RCBTB1 0.43 6.11 0.32 2.76e-9 Sum basophil neutrophil counts;Sum neutrophil eosinophil counts;Neutrophil count;Myeloid white cell count;Granulocyte count; CRC cis rs12928939 0.774 rs7205340 chr16:71645670 A/T cg08717414 chr16:71523259 ZNF19 0.47 6.0 0.31 5.11e-9 Post bronchodilator FEV1; CRC cis rs9372498 0.536 rs9489452 chr6:118910868 G/C cg01339444 chr6:118972232 C6orf204 0.52 5.97 0.31 6.11e-9 Diastolic blood pressure; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg15670579 chr15:102264312 TARSL2 0.41 6.59 0.34 1.73e-10 Liver disease severity in Alagille syndrome; CRC cis rs7937682 0.632 rs4936800 chr11:111734097 T/A cg09085632 chr11:111637200 PPP2R1B 0.95 15.6 0.65 1.9e-41 Primary sclerosing cholangitis; CRC cis rs9916302 0.706 rs8067511 chr17:37611352 C/T cg00129232 chr17:37814104 STARD3 -0.56 -6.71 -0.35 8.3e-11 Glomerular filtration rate (creatinine); CRC cis rs3091242 0.781 rs71652378 chr1:25721457 G/C cg27572855 chr1:25598939 RHD 0.35 6.1 0.32 2.92e-9 Erythrocyte sedimentation rate; CRC trans rs2303319 0.504 rs62189047 chr2:162613314 T/A cg22677401 chr17:46026860 NA -0.67 -6.07 -0.32 3.57e-9 Cognitive function; CRC cis rs6951245 0.872 rs77434655 chr7:1098405 G/A cg24642844 chr7:1081250 C7orf50 -0.76 -9.16 -0.45 5.78e-18 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs9527 0.545 rs10883847 chr10:104958284 C/T cg04362960 chr10:104952993 NT5C2 0.61 8.51 0.42 6.45e-16 Arsenic metabolism; CRC cis rs6580110 0.714 rs9324791 chr5:154078556 T/C cg11923914 chr5:154071666 NA -0.48 -7.34 -0.38 1.68e-12 Facial morphology (factor 9, facial height related to vertical position of nasion); CRC cis rs6461049 0.734 rs1558465 chr7:2151398 G/C cg22963979 chr7:1858916 MAD1L1 -0.4 -5.98 -0.31 5.68e-9 Schizophrenia; CRC cis rs6460942 0.915 rs62448621 chr7:12459941 G/A cg06484146 chr7:12443880 VWDE -0.78 -8.1 -0.41 1.11e-14 Coronary artery disease; CRC cis rs595982 0.527 rs73061659 chr19:49373556 G/A cg21252483 chr19:49399788 TULP2 -0.38 -6.01 -0.31 4.82e-9 Red cell distribution width; CRC trans rs4942242 0.512 rs9533552 chr13:44187194 C/T cg27382691 chr15:76552771 ETFA;TYRO3P -0.51 -6.57 -0.34 2e-10 Response to tocilizumab in rheumatoid arthritis; CRC cis rs1707322 0.963 rs6666763 chr1:46436451 C/A cg06784218 chr1:46089804 CCDC17 0.51 8.96 0.44 2.39e-17 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC trans rs561341 0.941 rs7215147 chr17:30266711 G/A cg20587970 chr11:113659929 NA -0.99 -14.53 -0.63 2.73e-37 Hip circumference adjusted for BMI; CRC cis rs7773004 0.905 rs3778279 chr6:26325463 T/C cg00631329 chr6:26305371 NA -0.4 -6.89 -0.36 2.86e-11 Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for body mass index;Waist circumference adjusted for BMI in non-smokers;Waist circumference adjusted for BMI (adjusted for smoking behaviour); CRC cis rs4481887 0.504 rs7529953 chr1:248357645 T/A cg00666640 chr1:248458726 OR2T12 0.44 7.11 0.37 7.14e-12 Common traits (Other); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg13108601 chr6:41748242 FRS3;PRICKLE4 0.5 7.2 0.37 4.2e-12 Response to antipsychotic treatment; CRC cis rs875971 0.545 rs4718364 chr7:66001340 C/A cg03233332 chr7:66118400 NA -0.43 -6.02 -0.31 4.74e-9 Aortic root size; CRC cis rs11123170 0.640 rs931472 chr2:113969948 C/T cg19083407 chr2:113993142 PAX8;LOC440839;LOC654433 -0.51 -6.77 -0.35 6.02e-11 Renal function-related traits (BUN); CRC cis rs2739330 0.796 rs5760106 chr22:24250645 A/C cg10819733 chr22:24237672 NA 0.34 5.7 0.3 2.7e-8 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs2645694 0.626 rs2645708 chr4:77822682 G/A cg18351406 chr4:77819688 ANKRD56 0.51 7.91 0.4 3.87e-14 Emphysema distribution in smoking; CRC cis rs7618915 0.501 rs7624716 chr3:52751534 T/C cg18099408 chr3:52552593 STAB1 -0.46 -7.71 -0.39 1.48e-13 Bipolar disorder; CRC trans rs12495832 0.778 rs76365698 chr3:147883980 A/G cg10221266 chr7:153579447 NA 0.55 6.02 0.31 4.67e-9 Chin dimples; CRC cis rs6963495 0.592 rs114793754 chr7:105152162 G/C cg13798780 chr7:105162888 PUS7 0.67 7.78 0.39 9.18e-14 Bipolar disorder (body mass index interaction); CRC cis rs7020830 0.861 rs2291589 chr9:37079661 T/G cg14294708 chr9:37120828 ZCCHC7 1.18 26.14 0.82 2.8e-82 Schizophrenia; CRC cis rs875971 0.660 rs801193 chr7:66030612 A/C cg18876405 chr7:65276391 NA -0.6 -10.83 -0.51 1.37e-23 Aortic root size; CRC cis rs6598955 0.671 rs13374173 chr1:26602256 T/G cg04990556 chr1:26633338 UBXN11 0.53 5.73 0.3 2.23e-8 Obesity-related traits; CRC cis rs1799949 1.000 rs35956818 chr17:41422985 T/C cg25072359 chr17:41440525 NA 0.45 6.84 0.35 3.83e-11 Menopause (age at onset); CRC cis rs875971 0.825 rs1000464 chr7:65777909 G/C cg18252515 chr7:66147081 NA 0.39 5.71 0.3 2.5e-8 Aortic root size; CRC cis rs1401999 1.000 rs6443924 chr3:183679532 A/G cg20387954 chr3:183756860 HTR3D 0.44 7.53 0.38 4.82e-13 Anterior chamber depth; CRC cis rs10876993 0.928 rs7136269 chr12:58075937 G/A cg18357645 chr12:58087776 OS9 0.6 8.43 0.42 1.11e-15 Celiac disease or Rheumatoid arthritis; CRC cis rs1707322 0.928 rs10732844 chr1:46372688 T/C cg03146154 chr1:46216737 IPP 0.51 7.16 0.37 5.32e-12 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs7412746 0.658 rs10305714 chr1:150800655 C/T cg15448220 chr1:150897856 SETDB1 -0.56 -7.99 -0.4 2.26e-14 Melanoma; CRC cis rs10876993 0.890 rs1678516 chr12:58047458 G/A cg18357645 chr12:58087776 OS9 0.56 7.65 0.39 2.2e-13 Celiac disease or Rheumatoid arthritis; CRC cis rs1950626 0.623 rs66722144 chr14:101457434 C/T cg02351406 chr14:101447389 SNORD114-20;SNORD114-21 0.76 12.31 0.56 6.42e-29 Pelvic organ prolapse (moderate/severe); CRC cis rs3845702 1.000 rs262279 chr2:180869145 G/A cg23417306 chr2:180868811 CWC22 0.48 6.63 0.34 1.39e-10 Schizophrenia; CRC cis rs601339 1.000 rs11059384 chr12:123170301 C/A cg25190513 chr12:123201362 GPR109B -0.48 -5.94 -0.31 7.24e-9 Adiponectin levels; CRC cis rs7666738 0.830 rs9307218 chr4:99024885 T/C cg05340658 chr4:99064831 C4orf37 0.59 8.97 0.44 2.22e-17 Colonoscopy-negative controls vs population controls; CRC cis rs800160 0.777 rs962902 chr11:2352225 T/C cg09785033 chr11:2336066 TSPAN32 -0.52 -5.92 -0.31 8.21e-9 Bacteremia; CRC cis rs554111 0.963 rs601329 chr1:21044161 A/G cg00373020 chr1:21041521 KIF17 0.42 6.48 0.34 3.41e-10 Facial morphology (factor 17, height of vermillion upper lip); CRC cis rs4332037 0.754 rs62436669 chr7:1926636 G/A cg23378565 chr7:2036160 MAD1L1 -0.44 -6.32 -0.33 8.4e-10 Bipolar disorder; CRC cis rs7149337 0.805 rs2999354 chr14:51607179 C/G cg23942311 chr14:51606299 NA 0.83 17.41 0.69 1.4e-48 Cancer; CRC cis rs10256972 0.516 rs12702081 chr7:1141528 T/C cg26608667 chr7:1196370 ZFAND2A 0.37 5.83 0.31 1.35e-8 Longevity;Endometriosis; CRC cis rs17270561 0.609 rs9393659 chr6:25731358 T/C cg17691542 chr6:26056736 HIST1H1C 0.73 9.26 0.45 2.71e-18 Iron status biomarkers; CRC cis rs735539 1.000 rs2290143 chr13:21280363 A/G cg04906043 chr13:21280425 IL17D 0.46 7.25 0.37 3.04e-12 Dental caries; CRC trans rs7615952 0.546 rs2976733 chr3:125414138 T/C cg00769240 chr8:12517080 NA -0.74 -10.46 -0.5 2.63e-22 Blood pressure (smoking interaction); CRC cis rs6921919 0.848 rs9468350 chr6:28319107 A/G cg15845792 chr6:28175446 NA 0.48 6.17 0.32 2.04e-9 Autism spectrum disorder or schizophrenia; CRC cis rs11792861 0.926 rs2271878 chr9:111868885 G/A cg05043794 chr9:111880884 C9orf5 -0.36 -6.55 -0.34 2.2e-10 Menarche (age at onset); CRC cis rs9322193 0.847 rs868375 chr6:150166041 T/A cg07701084 chr6:150067640 NUP43 0.47 6.29 0.33 1.01e-9 Lung cancer; CRC cis rs2153535 0.542 rs1120393 chr6:8486890 G/A cg21535247 chr6:8435926 SLC35B3 0.49 7.38 0.38 1.3e-12 Motion sickness; CRC cis rs4285028 0.948 rs34181646 chr3:121705373 T/A cg11130432 chr3:121712080 ILDR1 -0.5 -6.61 -0.34 1.56e-10 Multiple sclerosis; CRC cis rs6748734 0.843 rs6749674 chr2:241834501 G/C cg04034577 chr2:241836375 C2orf54 -0.42 -8.94 -0.44 2.85e-17 Urinary metabolites; CRC cis rs6860806 0.631 rs7736284 chr5:131588151 T/C cg12564285 chr5:131593104 PDLIM4 0.49 9.33 0.46 1.59e-18 Breast cancer; CRC cis rs9875589 0.509 rs4684174 chr3:14048375 C/T cg14375111 chr3:14165186 TMEM43;CHCHD4 0.41 5.94 0.31 7.39e-9 Ovarian reserve; CRC cis rs10857712 0.754 rs2297031 chr10:135232654 C/T cg19623624 chr10:135278901 LOC619207 -0.38 -6.15 -0.32 2.29e-9 Systemic lupus erythematosus; CRC cis rs10504229 0.683 rs55807014 chr8:58131801 T/C cg02725872 chr8:58115012 NA -0.64 -11.55 -0.54 3.85e-26 Developmental language disorder (linguistic errors); CRC cis rs7086803 0.793 rs6585182 chr10:114500402 A/G cg03281572 chr10:114502318 VTI1A 0.75 6.34 0.33 7.77e-10 Lung cancer; CRC cis rs62064224 0.597 rs7207268 chr17:30725155 T/G cg21839984 chr17:30846986 MYO1D -0.33 -5.61 -0.3 4.34e-8 Schizophrenia; CRC cis rs4665809 1.000 rs750452 chr2:26324995 G/A cg22920501 chr2:26401640 FAM59B -0.52 -7.15 -0.37 5.68e-12 Gut microbiome composition (summer); CRC cis rs597539 0.652 rs553875 chr11:68695144 T/G cg21963583 chr11:68658836 MRPL21 0.6 10.64 0.51 6.3e-23 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg01931797 chr11:77899910 KCTD21;USP35 0.47 6.78 0.35 5.52e-11 Intelligence (multi-trait analysis); CRC cis rs3741151 0.686 rs11544310 chr11:73107592 A/G cg17517138 chr11:73019481 ARHGEF17 0.58 6.1 0.32 2.9e-9 GIP levels in response to oral glucose tolerance test (120 minutes); CRC cis rs68170813 0.562 rs11770061 chr7:107071310 A/G cg02696742 chr7:106810147 HBP1 -0.58 -6.04 -0.32 4.16e-9 Coronary artery disease; CRC cis rs1129187 0.755 rs9471986 chr6:42944127 A/G cg26304593 chr6:42947056 PEX6 -0.46 -6.68 -0.35 1.03e-10 Alzheimer's disease in APOE e4+ carriers; CRC cis rs78456975 1.000 rs13400784 chr2:1564473 T/A cg26248373 chr2:1572462 NA -0.68 -7.51 -0.38 5.75e-13 Placebo response in major depressive disorder (% change in symptom score); CRC cis rs35883536 1.000 rs6663612 chr1:101085835 A/G cg14515779 chr1:101123966 NA -0.4 -7.24 -0.37 3.27e-12 Monocyte count; CRC cis rs4319547 0.619 rs10744208 chr12:122931559 C/A cg23029597 chr12:123009494 RSRC2 -0.55 -6.86 -0.35 3.34e-11 Body mass index; CRC cis rs7113874 0.589 rs725502 chr11:8503743 A/G cg17679104 chr11:8615758 STK33 0.35 5.78 0.3 1.77e-8 Body mass index in physically active individuals;Body mass index (joint analysis main effects and physical activity interaction); CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg05065690 chr12:49246007 DDX23 -0.56 -6.76 -0.35 6.29e-11 Diisocyanate-induced asthma; CRC cis rs17767392 1.000 rs723966 chr14:71765910 A/G cg13720639 chr14:72061746 SIPA1L1 -0.53 -6.81 -0.35 4.7e-11 Mitral valve prolapse; CRC cis rs2228479 0.571 rs62052183 chr16:89966921 C/A cg06558623 chr16:89946397 TCF25 1.04 11.08 0.52 1.92e-24 Skin colour saturation; CRC cis rs938554 0.779 rs6449173 chr4:9966105 A/C cg00071950 chr4:10020882 SLC2A9 -0.44 -5.95 -0.31 7e-9 Blood metabolite levels; CRC cis rs2797160 0.651 rs1268093 chr6:126029235 C/T cg05901451 chr6:126070800 HEY2 0.49 7.89 0.4 4.67e-14 Endometrial cancer; CRC cis rs921968 0.565 rs7562426 chr2:219605118 G/A cg02176678 chr2:219576539 TTLL4 -0.39 -6.19 -0.32 1.74e-9 Mean corpuscular hemoglobin concentration; CRC cis rs5850 0.602 rs1005786 chr7:23145837 G/C cg18081818 chr7:23246105 NA -0.33 -5.62 -0.3 4.07e-8 Blood protein levels; CRC cis rs1448094 0.512 rs10863086 chr12:86244225 G/A cg02569458 chr12:86230093 RASSF9 0.42 7.24 0.37 3.17e-12 Major depressive disorder; CRC cis rs7043114 0.525 rs7850432 chr9:95130510 G/A cg13798575 chr9:95087839 CENPP;NOL8 -0.4 -5.98 -0.31 5.7e-9 Height; CRC cis rs2932538 0.922 rs6663922 chr1:113095948 T/C cg22162597 chr1:113214053 CAPZA1 0.59 8.65 0.43 2.3e-16 Systolic blood pressure;Diastolic blood pressure;Hypertension;Blood pressure; CRC cis rs12762955 0.507 rs7095853 chr10:1040798 T/C cg26597838 chr10:835615 NA -0.45 -6.09 -0.32 3.2e-9 Response to angiotensin II receptor blocker therapy; CRC cis rs1448094 0.621 rs7315084 chr12:86283817 A/G cg18827107 chr12:86230957 RASSF9 -0.44 -7.15 -0.37 5.76e-12 Major depressive disorder; CRC cis rs1881492 0.518 rs940666 chr2:233458679 A/C cg03852847 chr2:233439513 NA -0.39 -6.22 -0.32 1.53e-9 Refractive error; CRC cis rs9322193 0.962 rs7818 chr6:150132092 A/G cg07701084 chr6:150067640 NUP43 0.47 6.59 0.34 1.74e-10 Lung cancer; CRC cis rs6461049 0.646 rs3778970 chr7:2143208 C/A cg21782813 chr7:2030301 MAD1L1 0.54 9.48 0.46 5.31e-19 Schizophrenia; CRC cis rs16975963 0.644 rs73033117 chr19:38073146 C/T cg15135657 chr19:38346511 NA -0.46 -6.24 -0.33 1.38e-9 Longevity; CRC cis rs1976403 0.633 rs1780324 chr1:21821757 A/G cg00786952 chr1:21763130 NA 0.5 8.33 0.42 2.21e-15 Liver enzyme levels (alkaline phosphatase); CRC cis rs2304069 0.913 rs7734382 chr5:149383241 A/T cg22760475 chr5:149380129 HMGXB3;TIGD6 0.87 9.97 0.48 1.21e-20 HIV-1 control; CRC cis rs4713118 0.824 rs9468229 chr6:27750086 G/A cg02683197 chr6:28174875 NA 0.66 8.59 0.43 3.46e-16 Parkinson's disease; CRC cis rs763121 0.889 rs1043402 chr22:38879688 G/A cg06022373 chr22:39101656 GTPBP1 0.72 10.52 0.5 1.67e-22 Menopause (age at onset); CRC cis rs1862618 0.853 rs832578 chr5:56164223 C/T cg18230493 chr5:56204884 C5orf35 -0.72 -9.09 -0.45 9.5e-18 Initial pursuit acceleration; CRC cis rs919433 0.926 rs787996 chr2:198216805 A/G cg10820045 chr2:198174542 NA 0.47 8.22 0.41 4.73e-15 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC trans rs916888 0.610 rs199446 chr17:44813169 G/A cg07870213 chr5:140052090 DND1 -0.59 -7.91 -0.4 4.05e-14 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs9325144 0.555 rs7955128 chr12:38684121 A/T cg13010199 chr12:38710504 ALG10B 0.4 5.71 0.3 2.55e-8 Morning vs. evening chronotype; CRC cis rs9916302 0.904 rs4239222 chr17:37696235 A/C cg15445000 chr17:37608096 MED1 -0.39 -8.65 -0.43 2.27e-16 Glomerular filtration rate (creatinine); CRC cis rs8077889 0.700 rs28571770 chr17:41904066 A/T cg26893861 chr17:41843967 DUSP3 0.87 12.21 0.56 1.52e-28 Triglycerides; CRC cis rs921968 0.643 rs535830 chr2:219372233 C/G cg02176678 chr2:219576539 TTLL4 0.49 8.05 0.41 1.58e-14 Mean corpuscular hemoglobin concentration; CRC cis rs28386778 1.000 rs2665851 chr17:61957023 T/C cg25654072 chr17:61904446 PSMC5;FTSJ3 0.7 10.89 0.51 8.53e-24 Prudent dietary pattern; CRC trans rs208520 0.955 rs9453664 chr6:66976079 A/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.84 10.38 0.5 4.9e-22 Exhaled nitric oxide output; CRC trans rs208520 0.690 rs7739253 chr6:66861052 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.05 -14.78 -0.63 3.02e-38 Exhaled nitric oxide output; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg02720131 chr3:9851598 TTLL3 -0.42 -6.29 -0.33 9.91e-10 Myopia (pathological); CRC cis rs4974559 0.790 rs5019560 chr4:1324793 G/A cg02980000 chr4:1222292 CTBP1 0.49 6.21 0.32 1.64e-9 Systolic blood pressure; CRC cis rs11645898 0.745 rs55824906 chr16:72064905 A/G cg14768367 chr16:72042858 DHODH -0.74 -7.66 -0.39 2.14e-13 Blood protein levels; CRC cis rs62064224 0.614 rs4794921 chr17:30742310 C/T cg12855166 chr17:30846586 MYO1D -0.35 -5.63 -0.3 3.85e-8 Schizophrenia; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg20155988 chr1:1590632 CDK11B 0.45 6.34 0.33 7.44e-10 Anxiety disorder; CRC cis rs9420 0.925 rs488769 chr11:57450720 A/C cg23127183 chr11:57508653 C11orf31 -0.53 -7.44 -0.38 8.82e-13 Schizophrenia; CRC cis rs6502050 0.765 rs6502074 chr17:80121776 T/C cg02741985 chr17:80059408 CCDC57 0.43 7.16 0.37 5.44e-12 Life satisfaction; CRC cis rs861020 0.606 rs2184919 chr1:210000015 C/T cg05527609 chr1:210001259 C1orf107 -0.81 -11.07 -0.52 2.08e-24 Orofacial clefts; CRC cis rs7843479 1.000 rs2306641 chr8:21833965 A/G cg17168535 chr8:21777572 XPO7 -0.54 -8.9 -0.44 3.9e-17 Mean corpuscular volume; CRC cis rs4722166 0.695 rs7793125 chr7:22809160 A/G cg05472934 chr7:22766657 IL6 0.67 10.82 0.51 1.52e-23 Lung cancer; CRC cis rs2404602 0.631 rs9646213 chr15:76807672 G/C cg00316803 chr15:76480434 C15orf27 -0.35 -5.7 -0.3 2.64e-8 Blood metabolite levels; CRC cis rs10504229 0.679 rs111843870 chr8:58126798 A/G cg22535103 chr8:58192502 C8orf71 -0.7 -9.34 -0.46 1.47e-18 Developmental language disorder (linguistic errors); CRC cis rs4975709 0.569 rs2077269 chr5:1863506 C/T cg15595755 chr5:1867978 NA 0.37 6.19 0.32 1.78e-9 Cardiovascular disease risk factors; CRC cis rs11583043 1.000 rs3861734 chr1:101489461 A/T cg16556008 chr1:101360663 SLC30A7;EXTL2 0.45 5.76 0.3 1.89e-8 Ulcerative colitis;Inflammatory bowel disease; CRC trans rs7580658 0.614 rs7585198 chr2:127962635 C/T cg00530740 chr6:53409368 GCLC -0.46 -6.25 -0.33 1.27e-9 Protein C levels; CRC cis rs889312 0.500 rs832570 chr5:56156408 G/A cg03609598 chr5:56110824 MAP3K1 -0.41 -5.78 -0.3 1.7e-8 Breast cancer;Breast cancer (early onset); CRC cis rs1448094 0.511 rs10779210 chr12:86162432 T/C cg19622623 chr12:86230825 RASSF9 0.38 6.02 0.32 4.62e-9 Major depressive disorder; CRC cis rs10504229 0.683 rs59528137 chr8:58138565 C/T cg22535103 chr8:58192502 C8orf71 -0.8 -8.99 -0.44 2.05e-17 Developmental language disorder (linguistic errors); CRC cis rs6694672 1.000 rs928439 chr1:196950482 G/A cg13682187 chr1:196946512 CFHR5 -0.48 -7.61 -0.39 2.83e-13 Asthma; CRC cis rs4474465 1.000 rs7943673 chr11:78172986 A/G cg27205649 chr11:78285834 NARS2 -0.48 -5.85 -0.31 1.18e-8 Alzheimer's disease (survival time); CRC cis rs12980942 0.591 rs11879429 chr19:41757444 G/A cg25627403 chr19:41769009 HNRNPUL1 0.57 6.6 0.34 1.67e-10 Coronary artery disease; CRC cis rs9649213 0.574 rs17436977 chr7:97883459 T/C cg21770322 chr7:97807741 LMTK2 0.59 9.85 0.48 3.04e-20 Prostate cancer (SNP x SNP interaction); CRC cis rs422249 0.512 rs1535 chr11:61597972 A/G cg00603274 chr11:61596626 FADS2 -0.42 -6.03 -0.32 4.39e-9 Trans fatty acid levels; CRC cis rs11648796 0.765 rs2003832 chr16:769538 G/A cg27144592 chr16:783916 NARFL 0.69 9.91 0.48 1.97e-20 Height; CRC cis rs10540 1.000 rs61876326 chr11:467368 A/G cg03352830 chr11:487213 PTDSS2 0.67 7.86 0.4 5.71e-14 Body mass index; CRC cis rs5498 0.869 rs892188 chr19:10409793 A/G cg10604476 chr19:10403908 ICAM5 -0.3 -5.76 -0.3 1.95e-8 Lymphocyte counts;Soluble ICAM-1;Blood protein levels; CRC cis rs12926788 0.640 rs12924246 chr16:24844629 A/G cg06505273 chr16:24850292 NA 0.52 6.82 0.35 4.42e-11 Ejection fraction in Tripanosoma cruzi seropositivity; CRC cis rs3026101 0.671 rs3944127 chr17:5297766 C/G cg25236894 chr17:5323110 RPAIN;NUP88 0.42 6.79 0.35 5.16e-11 Body mass index; CRC cis rs950776 0.518 rs12915428 chr15:78823368 G/A cg06917634 chr15:78832804 PSMA4 0.66 10.42 0.5 3.55e-22 Sudden cardiac arrest; CRC cis rs6547741 0.935 rs6761095 chr2:27778010 G/T cg27432699 chr2:27873401 GPN1 0.75 13.85 0.61 1.12e-34 Oral cavity cancer; CRC trans rs9291683 0.588 rs3796842 chr4:9995851 A/T cg26043149 chr18:55253948 FECH 0.49 7.84 0.4 6.4e-14 Bone mineral density; CRC cis rs6502050 0.749 rs7209948 chr17:80086804 T/G cg19223190 chr17:80058835 NA -0.39 -6.25 -0.33 1.27e-9 Life satisfaction; CRC cis rs2594989 0.836 rs347609 chr3:11269999 G/C cg00170343 chr3:11313890 ATG7 0.53 6.09 0.32 3.07e-9 Circulating chemerin levels; CRC cis rs4803480 0.554 rs12462194 chr19:42072289 G/A cg08478046 chr19:42093086 CEACAM21 -0.3 -6.19 -0.32 1.81e-9 Schizophrenia; CRC cis rs514406 0.929 rs554301 chr1:53321948 A/T cg24675658 chr1:53192096 ZYG11B 0.52 7.82 0.4 7.17e-14 Monocyte count; CRC cis rs9902453 1.000 rs8065261 chr17:28418041 C/T cg26525008 chr17:28256777 EFCAB5;SSH2 -0.58 -8.6 -0.43 3.27e-16 Coffee consumption (cups per day); CRC cis rs9814567 0.964 rs9820150 chr3:134223011 C/G cg06109529 chr3:134205091 CEP63;ANAPC13 -0.81 -12.08 -0.55 4.67e-28 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg01830644 chr10:12110754 DHTKD1 0.41 5.98 0.31 5.8e-9 Intelligence (multi-trait analysis); CRC cis rs853679 0.517 rs56310871 chr6:28044482 A/G cg06470822 chr6:28175283 NA 0.98 13.17 0.59 4.07e-32 Depression; CRC cis rs10791323 0.604 rs2723598 chr11:133711652 G/A cg06766960 chr11:133703094 NA -0.35 -5.75 -0.3 2.04e-8 Childhood ear infection; CRC cis rs7926971 0.756 rs6485968 chr11:12660201 G/A cg25843174 chr11:12811716 TEAD1 0.35 6.08 0.32 3.33e-9 Height; CRC cis rs8177253 0.606 rs6787177 chr3:133450720 C/T cg16262614 chr3:133464971 TF 0.4 7.13 0.37 6.4e-12 Iron status biomarkers; CRC cis rs2477686 0.526 rs2477690 chr1:2395563 G/A cg02850689 chr1:2391347 NA -0.4 -6.39 -0.33 5.83e-10 Non-obstructive azoospermia; CRC cis rs2857891 1.000 rs2638092 chr11:6961746 G/A cg04053776 chr11:6947353 ZNF215 0.52 7.01 0.36 1.35e-11 Response to cytadine analogues (cytosine arabinoside); CRC cis rs2249625 0.545 rs2496495 chr6:72882414 G/A cg18830697 chr6:72922368 RIMS1 -0.39 -7.9 -0.4 4.11e-14 Acute urticaria and angioedema (non-steroidal anti-inflammatory drug-induced); CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg04657831 chr21:46707951 POFUT2;LOC642852 0.43 6.06 0.32 3.8e-9 Anxiety disorder; CRC cis rs853679 0.517 rs55747925 chr6:28044337 T/C cg18032046 chr6:28092343 ZSCAN16 -0.5 -5.89 -0.31 9.74e-9 Depression; CRC cis rs540254 0.551 rs12143580 chr1:160790918 G/C cg20255094 chr1:160771763 LY9 0.49 6.41 0.33 5.13e-10 Blood protein levels; CRC cis rs6662572 0.737 rs72692632 chr1:46437192 A/C cg08644498 chr1:46502608 NA 0.44 6.82 0.35 4.28e-11 Blood protein levels; CRC cis rs7172677 0.732 rs1867147 chr15:75363357 C/T cg14664628 chr15:75095509 CSK 0.51 5.94 0.31 7.14e-9 Systemic lupus erythematosus and Systemic sclerosis; CRC trans rs1973993 0.745 rs6686016 chr1:96948002 G/A cg10631902 chr5:14652156 NA -0.43 -7.24 -0.37 3.24e-12 Weight; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg20803232 chr8:42995089 HGSNAT 0.43 6.37 0.33 6.53e-10 Intelligence (multi-trait analysis); CRC cis rs6700896 0.931 rs12034502 chr1:66099831 C/T cg04111102 chr1:66153794 NA 0.32 5.67 0.3 3.12e-8 C-reactive protein;Mean corpuscular volume;Mean corpuscular hemoglobin; CRC cis rs736408 0.609 rs13082960 chr3:52785168 A/C cg15147215 chr3:52552868 STAB1 -0.61 -9.99 -0.48 1.06e-20 Bipolar disorder; CRC cis rs2635047 0.811 rs12962421 chr18:44787498 A/G cg19077165 chr18:44547161 KATNAL2 -0.39 -5.94 -0.31 7.29e-9 Educational attainment; CRC cis rs72772090 0.539 rs10515250 chr5:96150193 T/C cg17330273 chr5:96107758 CAST;ERAP1 -0.62 -6.04 -0.32 4.22e-9 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs6089584 0.888 rs6061979 chr20:60617141 C/G cg23463467 chr20:60627584 TAF4 0.33 5.75 0.3 2.03e-8 Body mass index; CRC cis rs7666738 0.830 rs11935078 chr4:99010476 T/A cg17366294 chr4:99064904 C4orf37 0.45 7.58 0.39 3.6e-13 Colonoscopy-negative controls vs population controls; CRC cis rs9311474 0.508 rs4687546 chr3:52605943 T/A cg15147215 chr3:52552868 STAB1 -0.65 -11.29 -0.53 3.36e-25 Electroencephalogram traits; CRC cis rs7191439 0.858 rs4238685 chr16:88775220 T/C cg02389323 chr16:88786976 FAM38A 1.11 9.19 0.45 4.5e-18 Plateletcrit; CRC cis rs644799 0.862 rs1150361 chr11:95633805 G/A cg03916912 chr11:95522834 CEP57;FAM76B 0.95 17.68 0.7 1.16e-49 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs1448094 0.511 rs10779207 chr12:86152913 A/G cg00310523 chr12:86230176 RASSF9 -0.38 -6.09 -0.32 3.19e-9 Major depressive disorder; CRC cis rs13108904 0.901 rs4516656 chr4:1279860 A/G cg05665937 chr4:1216051 CTBP1 0.4 5.78 0.3 1.74e-8 Obesity-related traits; CRC cis rs769267 1.000 rs7247309 chr19:19439631 A/T cg02546618 chr19:19431379 KIAA0892;SF4 -0.47 -6.65 -0.34 1.24e-10 Tonsillectomy; CRC cis rs4474465 1.000 rs7928933 chr11:78193921 T/C cg27205649 chr11:78285834 NARS2 -0.48 -5.84 -0.31 1.25e-8 Alzheimer's disease (survival time); CRC cis rs7274811 0.688 rs56234419 chr20:32086447 C/T cg03904042 chr20:32255491 NECAB3;C20orf134 -0.46 -6.48 -0.34 3.25e-10 Height; CRC cis rs3736594 0.959 rs6547796 chr2:27975394 T/C cg27432699 chr2:27873401 GPN1 -0.6 -8.31 -0.42 2.52e-15 Fasting blood glucose;Fasting blood glucose (BMI interaction); CRC cis rs6964587 1.000 rs6968870 chr7:91661111 G/C cg17063962 chr7:91808500 NA 0.77 13.12 0.59 6.18e-32 Breast cancer; CRC cis rs473651 0.935 rs508483 chr2:239339709 T/C cg21699342 chr2:239360505 ASB1 0.58 10.54 0.5 1.4e-22 Multiple system atrophy; CRC cis rs736408 0.609 rs62255396 chr3:52782839 C/T cg11645453 chr3:52864694 ITIH4 0.35 6.1 0.32 3.04e-9 Bipolar disorder; CRC cis rs798554 0.660 rs2527694 chr7:2858240 T/C cg13628971 chr7:2884303 GNA12 0.4 6.19 0.32 1.74e-9 Height; CRC cis rs4481887 0.617 rs28719164 chr1:248543802 T/G cg00666640 chr1:248458726 OR2T12 0.35 6.52 0.34 2.63e-10 Common traits (Other); CRC cis rs7119 0.931 rs59418918 chr15:77833110 A/C cg10437265 chr15:77819839 NA 0.59 10.74 0.51 2.95e-23 Type 2 diabetes; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg14803350 chr5:159545855 PWWP2A 0.38 6.02 0.31 4.56e-9 Liver disease severity in Alagille syndrome; CRC cis rs709400 1.000 rs3915733 chr14:104147353 G/A cg12935359 chr14:103987150 CKB -0.4 -6.73 -0.35 7.55e-11 Body mass index; CRC cis rs1862618 0.525 rs2662016 chr5:56269047 A/G cg18230493 chr5:56204884 C5orf35 0.76 10.28 0.49 1.07e-21 Initial pursuit acceleration; CRC cis rs362272 0.505 rs10155132 chr4:3369500 A/G cg11471262 chr4:3318911 RGS12 -0.37 -5.74 -0.3 2.11e-8 Serum sulfate level; CRC cis rs17253792 0.545 rs35536987 chr14:56024021 A/G cg01858014 chr14:56050164 KTN1 -0.86 -6.61 -0.34 1.56e-10 Putamen volume; CRC cis rs3741151 0.773 rs7950375 chr11:73281345 G/A cg17517138 chr11:73019481 ARHGEF17 0.96 7.44 0.38 8.7e-13 GIP levels in response to oral glucose tolerance test (120 minutes); CRC cis rs2842992 0.724 rs2273827 chr6:160211339 C/A cg11366901 chr6:160182831 ACAT2 0.73 10.92 0.52 6.54e-24 Age-related macular degeneration (geographic atrophy); CRC cis rs12928939 0.768 rs11861296 chr16:71850632 T/C cg03805757 chr16:71968109 PKD1L3 -0.48 -6.04 -0.32 4.18e-9 Post bronchodilator FEV1; CRC cis rs12188164 0.525 rs2561665 chr5:460135 A/G cg14122633 chr5:456516 EXOC3 -0.4 -7.13 -0.37 6.3e-12 Cystic fibrosis severity; CRC cis rs6694672 1.000 rs4915315 chr1:197059878 G/A cg13682187 chr1:196946512 CFHR5 0.44 7.2 0.37 4.07e-12 Asthma; CRC cis rs11249608 0.548 rs6875622 chr5:178451397 C/T cg01312482 chr5:178451176 ZNF879 -0.37 -6.15 -0.32 2.26e-9 Pubertal anthropometrics; CRC cis rs10504229 1.000 rs68076606 chr8:58191271 A/G cg05313129 chr8:58192883 C8orf71 -0.47 -6.99 -0.36 1.49e-11 Developmental language disorder (linguistic errors); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg27383215 chr2:201729287 CLK1 0.46 6.25 0.33 1.24e-9 Response to antipsychotic treatment; CRC trans rs2727020 0.521 rs4980445 chr11:49570183 C/T cg15704280 chr7:45808275 SEPT13 -0.76 -10.35 -0.5 6.2e-22 Coronary artery disease; CRC cis rs12024301 0.557 rs12034427 chr1:183660238 T/A cg11505048 chr1:183622726 RGL1;APOBEC4 0.71 6.24 0.33 1.33e-9 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs2976388 0.507 rs7813604 chr8:143838062 G/A cg15511327 chr8:143859410 LYNX1 0.5 8.74 0.43 1.24e-16 Urinary tract infection frequency; CRC cis rs9768139 0.935 rs116290351 chr7:158119712 T/A cg25566285 chr7:158114605 PTPRN2 -0.59 -10.05 -0.48 6.6e-21 Calcium levels; CRC cis rs6598955 0.670 rs4659366 chr1:26542572 G/A cg04990556 chr1:26633338 UBXN11 -0.8 -13.29 -0.59 1.42e-32 Obesity-related traits; CRC cis rs9828933 0.766 rs3774725 chr3:63974258 T/G cg16258503 chr3:63850278 ATXN7;THOC7 -0.78 -8.66 -0.43 2.16e-16 Type 2 diabetes; CRC cis rs4665809 0.941 rs1470096 chr2:26311482 T/C cg22920501 chr2:26401640 FAM59B -0.56 -7.3 -0.37 2.22e-12 Gut microbiome composition (summer); CRC cis rs6088590 1.000 rs6120750 chr20:33465289 A/C cg08999081 chr20:33150536 PIGU 0.49 8.17 0.41 6.65e-15 Coronary artery disease; CRC trans rs11098499 0.954 rs10008459 chr4:120394231 T/C cg25214090 chr10:38739885 LOC399744 0.66 10.67 0.51 5.22e-23 Corneal astigmatism; CRC cis rs9611565 0.729 rs203319 chr22:41914593 C/T cg06634786 chr22:41940651 POLR3H -0.51 -6.86 -0.35 3.43e-11 Vitiligo; CRC cis rs1784581 0.569 rs9364629 chr6:162416831 T/G cg17173639 chr6:162384350 PARK2 0.6 9.72 0.47 8.36e-20 Itch intensity from mosquito bite; CRC cis rs4409675 0.527 rs12067053 chr1:28227122 T/G cg23691781 chr1:28212827 C1orf38 0.34 7.88 0.4 4.91e-14 Corneal astigmatism; CRC cis rs10876993 0.890 rs810204 chr12:58075733 T/C cg15848620 chr12:58087721 OS9 -0.61 -8.35 -0.42 1.97e-15 Celiac disease or Rheumatoid arthritis; CRC cis rs7258465 1.000 rs4808804 chr19:18585325 A/G cg01065977 chr19:18549689 ISYNA1 -0.41 -6.35 -0.33 7.25e-10 Breast cancer; CRC trans rs1814175 0.817 rs7929173 chr11:49944007 T/C cg03929089 chr4:120376271 NA -0.98 -19.07 -0.72 4.11e-55 Height; CRC trans rs7395662 0.681 rs2865641 chr11:48941099 A/C cg21153622 chr11:89784906 NA -0.46 -7.26 -0.37 2.9e-12 HDL cholesterol; CRC cis rs2153535 0.580 rs9328484 chr6:8524843 A/T cg07606381 chr6:8435919 SLC35B3 0.66 10.79 0.51 1.86e-23 Motion sickness; CRC cis rs2576037 0.899 rs2571034 chr18:44578565 A/G cg20875182 chr18:44561130 TCEB3B;KATNAL2 -0.46 -7.35 -0.38 1.54e-12 Personality dimensions; CRC cis rs4481887 0.888 rs12042602 chr1:248482053 C/T cg00666640 chr1:248458726 OR2T12 0.49 8.34 0.42 2.08e-15 Common traits (Other); CRC cis rs10782582 0.609 rs1498311 chr1:76254726 A/C cg03433033 chr1:76189801 ACADM 0.4 5.83 0.31 1.36e-8 Daytime sleep phenotypes; CRC cis rs4713118 0.955 rs9368528 chr6:27683798 G/A cg03623178 chr6:28175578 NA 0.63 8.4 0.42 1.36e-15 Parkinson's disease; CRC cis rs3768617 0.811 rs12022720 chr1:183017223 A/G ch.1.3577855R chr1:183094577 LAMC1 0.6 8.83 0.44 6.16e-17 Fuchs's corneal dystrophy; CRC cis rs4466137 0.903 rs3734092 chr5:83016743 C/T cg16102102 chr5:83017553 HAPLN1 -0.54 -7.73 -0.39 1.35e-13 Prostate cancer; CRC cis rs11997175 0.624 rs7464055 chr8:33679382 G/A cg04338863 chr8:33670619 NA 0.44 7.06 0.36 9.65e-12 Body mass index; CRC cis rs561341 1.000 rs117979353 chr17:30272866 A/G cg23018236 chr17:30244563 NA -0.65 -7.74 -0.39 1.21e-13 Hip circumference adjusted for BMI; CRC cis rs67311347 1.000 rs1004655 chr3:40490009 G/A cg09455208 chr3:40491958 NA 0.5 9.79 0.48 4.89e-20 Renal cell carcinoma; CRC cis rs853679 0.517 rs9393891 chr6:28079160 C/T cg21251018 chr6:28226885 NKAPL 0.48 6.19 0.32 1.84e-9 Depression; CRC cis rs4713118 0.513 rs149897 chr6:28006650 A/G cg25164649 chr6:28176230 NA 0.61 8.86 0.44 4.96e-17 Parkinson's disease; CRC trans rs2797160 1.000 rs13328298 chr6:126016580 G/A cg05039488 chr6:79577232 IRAK1BP1 0.51 7.59 0.39 3.37e-13 Endometrial cancer; CRC cis rs2243480 0.666 rs1880311 chr7:65276752 G/C cg25985355 chr7:65971099 NA 0.51 5.77 0.3 1.85e-8 Diabetic kidney disease; CRC cis rs2050392 0.517 rs602097 chr10:30747546 C/T cg18806716 chr10:30721971 MAP3K8 -0.59 -8.33 -0.42 2.16e-15 Inflammatory bowel disease; CRC cis rs6951245 0.935 rs79067319 chr7:1065548 C/T cg20603222 chr7:1096387 C7orf50;GPR146 -0.66 -7.78 -0.39 9.53e-14 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs10992471 0.756 rs10123342 chr9:95087824 T/G cg13798575 chr9:95087839 CENPP;NOL8 -0.48 -7.01 -0.36 1.33e-11 Visceral adipose tissue/subcutaneous adipose tissue ratio; CRC cis rs12594515 1.000 rs6493172 chr15:45987213 T/G cg22117107 chr15:45993392 NA -0.44 -9.07 -0.45 1.08e-17 Waist circumference;Weight; CRC trans rs11098499 0.743 rs10003567 chr4:120241674 C/T cg25214090 chr10:38739885 LOC399744 0.53 8.36 0.42 1.78e-15 Corneal astigmatism; CRC cis rs7412746 0.646 rs1972060 chr1:150937594 T/C cg10589385 chr1:150898437 SETDB1 0.27 5.93 0.31 7.65e-9 Melanoma; CRC trans rs7937682 0.881 rs4936678 chr11:111625085 C/T cg18187862 chr3:45730750 SACM1L -0.52 -6.85 -0.35 3.69e-11 Primary sclerosing cholangitis; CRC cis rs4253772 0.591 rs8135363 chr22:46651713 T/C cg03482458 chr22:46692211 CN5H6.4;GTSE1 0.47 6.22 0.32 1.48e-9 LDL cholesterol;Cholesterol, total; CRC trans rs11088226 0.681 rs11700670 chr21:33938615 T/C cg09050820 chr6:167586206 TCP10L2 0.81 8.55 0.43 4.61e-16 Gastritis; CRC trans rs9291683 0.609 rs13149985 chr4:10028390 G/A cg26043149 chr18:55253948 FECH 0.53 8.1 0.41 1.08e-14 Bone mineral density; CRC cis rs9733 0.628 rs11807409 chr1:150683423 C/T cg10589385 chr1:150898437 SETDB1 0.28 6.0 0.31 5.31e-9 Tonsillectomy; CRC cis rs58688157 0.705 rs12421646 chr11:578844 C/G cg14433983 chr11:636460 DRD4 -0.45 -5.86 -0.31 1.1e-8 Systemic lupus erythematosus; CRC trans rs7301826 0.627 rs7315707 chr12:131272819 A/G cg05838956 chr11:6704805 MRPL17 0.47 6.19 0.32 1.83e-9 Plasma plasminogen activator levels; CRC cis rs6951245 1.000 rs113146460 chr7:1105164 C/G cg03188948 chr7:1209495 NA 0.65 6.85 0.35 3.68e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs1816752 0.905 rs7995909 chr13:25013297 T/C cg02811702 chr13:24901961 NA 0.47 6.55 0.34 2.16e-10 Obesity-related traits; CRC cis rs6952808 0.608 rs58120505 chr7:2029867 T/C cg04267008 chr7:1944627 MAD1L1 -0.61 -8.82 -0.44 6.83e-17 Bipolar disorder and schizophrenia; CRC cis rs3858526 0.665 rs10839170 chr11:6003512 C/T cg13902645 chr11:5959945 NA -0.48 -6.25 -0.33 1.29e-9 DNA methylation (variation); CRC cis rs7618915 0.621 rs6788993 chr3:52605136 T/C cg14092988 chr3:52407081 DNAH1 0.29 5.61 0.3 4.24e-8 Bipolar disorder; CRC cis rs2303759 0.709 rs7256363 chr19:49827804 C/T cg22590775 chr19:49891494 CCDC155 0.6 7.9 0.4 4.3e-14 Multiple sclerosis; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg22973319 chr3:50310839 SEMA3B 0.44 6.03 0.32 4.35e-9 Anxiety disorder; CRC cis rs870825 0.549 rs7699919 chr4:185648610 A/C cg04058563 chr4:185651563 MLF1IP 0.72 9.11 0.45 8.52e-18 Blood protein levels; CRC cis rs7937682 1.000 rs2186839 chr11:111534442 T/G cg19812747 chr11:111475976 SIK2 -0.56 -9.45 -0.46 6.39e-19 Primary sclerosing cholangitis; CRC cis rs1209950 0.536 rs464366 chr21:40225071 C/T cg02119577 chr21:40195074 ETS2 -0.36 -5.7 -0.3 2.71e-8 Non-small cell lung cancer (survival); CRC cis rs6754311 0.731 rs6719488 chr2:136575199 G/T cg15123519 chr2:136567270 LCT 0.33 6.39 0.33 5.65e-10 Mosquito bite size; CRC cis rs6424115 0.931 rs11800561 chr1:24164398 T/G cg09473613 chr1:24152604 HMGCL 0.35 6.0 0.31 5.34e-9 Immature fraction of reticulocytes; CRC cis rs9486719 0.901 rs13206547 chr6:97006942 T/C cg06623918 chr6:96969491 KIAA0776 -0.82 -9.53 -0.47 3.58e-19 Migraine;Coronary artery disease; CRC cis rs9322193 0.847 rs56103941 chr6:150137231 A/G cg07701084 chr6:150067640 NUP43 0.59 8.05 0.41 1.54e-14 Lung cancer; CRC cis rs9467711 0.659 rs13220261 chr6:26499185 C/T cg08501292 chr6:25962987 TRIM38 0.88 6.11 0.32 2.84e-9 Autism spectrum disorder or schizophrenia; CRC cis rs9911578 1.000 rs8076121 chr17:57041699 G/A cg12560992 chr17:57184187 TRIM37 0.93 17.28 0.69 4.48e-48 Intelligence (multi-trait analysis); CRC cis rs4665809 0.938 rs6742226 chr2:26342537 A/G cg25036284 chr2:26402008 FAM59B -0.46 -6.01 -0.31 4.83e-9 Gut microbiome composition (summer); CRC trans rs61931739 0.534 rs11052974 chr12:34029877 T/G cg26384229 chr12:38710491 ALG10B 0.53 6.72 0.35 8.12e-11 Morning vs. evening chronotype; CRC cis rs4555082 0.915 rs2816632 chr14:105741355 C/T cg13114125 chr14:105738426 BRF1 0.7 11.03 0.52 2.83e-24 Mean platelet volume;Platelet distribution width; CRC cis rs10782582 0.593 rs77208152 chr1:76124255 T/C cg10523679 chr1:76189770 ACADM -0.4 -5.66 -0.3 3.28e-8 Daytime sleep phenotypes; CRC cis rs8141529 0.764 rs5752812 chr22:29225603 T/A cg02153584 chr22:29168773 CCDC117 0.52 7.8 0.4 8e-14 Lymphocyte counts; CRC cis rs6502050 0.835 rs7503189 chr17:80099486 C/A cg02741985 chr17:80059408 CCDC57 0.43 7.15 0.37 5.66e-12 Life satisfaction; CRC cis rs477692 0.673 rs511361 chr10:131365052 C/T cg05714579 chr10:131428358 MGMT 0.46 6.53 0.34 2.55e-10 Response to temozolomide; CRC trans rs11673344 0.528 rs563786 chr19:37412914 A/G cg18947437 chr10:1231002 ADARB2 -0.36 -6.39 -0.33 5.73e-10 Obesity-related traits; CRC cis rs1005277 0.579 rs2474567 chr10:38382492 C/T cg25517755 chr10:38738941 LOC399744 -0.44 -6.42 -0.33 4.82e-10 Extrinsic epigenetic age acceleration; CRC cis rs853679 0.517 rs9393887 chr6:28059020 G/A cg21251018 chr6:28226885 NKAPL 0.48 6.34 0.33 7.69e-10 Depression; CRC cis rs561341 0.883 rs7406056 chr17:30220224 C/T cg19193384 chr17:30244184 NA -0.52 -6.28 -0.33 1.1e-9 Hip circumference adjusted for BMI; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg26335527 chr1:155100185 EFNA1 0.41 6.28 0.33 1.06e-9 Intelligence (multi-trait analysis); CRC cis rs7149337 0.805 rs4350491 chr14:51675798 A/G cg23942311 chr14:51606299 NA 0.73 13.06 0.58 1.06e-31 Cancer; CRC cis rs4285028 0.948 rs10934565 chr3:121664661 G/A cg11130432 chr3:121712080 ILDR1 -0.5 -6.62 -0.34 1.45e-10 Multiple sclerosis; CRC cis rs926938 0.527 rs6680112 chr1:115548915 G/C cg12756093 chr1:115239321 AMPD1 0.47 6.79 0.35 5.26e-11 Autism; CRC cis rs2739330 0.760 rs5751760 chr22:24243573 G/A cg23131131 chr22:24373011 LOC391322 -0.63 -9.6 -0.47 2.09e-19 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs11583043 0.918 rs56402739 chr1:101397133 A/G cg16556008 chr1:101360663 SLC30A7;EXTL2 0.57 7.73 0.39 1.35e-13 Ulcerative colitis;Inflammatory bowel disease; CRC cis rs7584330 0.666 rs72620818 chr2:238354652 G/A cg14458575 chr2:238380390 NA 0.9 16.04 0.66 3.36e-43 Prostate cancer; CRC cis rs12134245 0.776 rs61548854 chr1:92001536 C/T cg21854759 chr1:92012499 NA -0.53 -8.79 -0.44 8.36e-17 Breast cancer; CRC cis rs4319547 0.695 rs1973463 chr12:122938003 A/G cg05707623 chr12:122985044 ZCCHC8 -0.65 -8.21 -0.41 5.19e-15 Body mass index; CRC cis rs4803468 1.000 rs4803463 chr19:41911040 C/G cg09537434 chr19:41945824 ATP5SL -0.94 -18.44 -0.71 1.16e-52 Height; CRC cis rs826838 0.934 rs10875647 chr12:38856995 G/A cg26384229 chr12:38710491 ALG10B 0.75 10.47 0.5 2.52e-22 Heart rate; CRC cis rs763121 0.853 rs2072795 chr22:39064209 A/G cg06022373 chr22:39101656 GTPBP1 -0.79 -12.65 -0.57 3.57e-30 Menopause (age at onset); CRC cis rs911119 0.955 rs1555355 chr20:23594580 T/C cg16589663 chr20:23618590 CST3 0.44 6.18 0.32 1.94e-9 Chronic kidney disease; CRC cis rs1476670 0.710 rs2485993 chr1:44503040 C/T cg09470012 chr1:44509516 NA -0.42 -6.97 -0.36 1.76e-11 Eotaxin levels; CRC cis rs2625529 0.878 rs2929511 chr15:72231682 C/T cg16672083 chr15:72433130 SENP8 0.47 7.0 0.36 1.49e-11 Red blood cell count; CRC cis rs60871478 0.636 rs4721834 chr7:896142 C/T cg13844804 chr7:814759 HEATR2 -0.54 -5.76 -0.3 1.94e-8 Cerebrospinal P-tau181p levels; CRC cis rs798554 0.679 rs2644281 chr7:2886748 A/G cg13628971 chr7:2884303 GNA12 0.62 8.92 0.44 3.38e-17 Height; CRC trans rs1864729 1.000 rs2439700 chr8:98277168 G/A cg08679828 chr8:102218111 ZNF706 -0.61 -7.34 -0.38 1.67e-12 Estradiol plasma levels (breast cancer); CRC cis rs7258465 0.931 rs271629 chr19:18623198 G/A cg06462663 chr19:18546047 ISYNA1 0.48 7.37 0.38 1.39e-12 Breast cancer; CRC cis rs3859192 0.539 rs2302774 chr17:38183090 G/T cg17467752 chr17:38218738 THRA -0.52 -7.57 -0.39 3.77e-13 White blood cell count; CRC cis rs6951245 1.000 rs77346188 chr7:1114023 C/A cg21664854 chr7:1097933 C7orf50;GPR146 0.78 8.76 0.43 1.05e-16 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs1129187 0.818 rs9462858 chr6:42946490 C/A cg10862848 chr6:42927986 GNMT -0.37 -8.56 -0.43 4.36e-16 Alzheimer's disease in APOE e4+ carriers; CRC cis rs13108904 0.967 rs900027 chr4:1279360 G/A cg19318889 chr4:1322082 MAEA 0.41 5.84 0.31 1.23e-8 Obesity-related traits; CRC cis rs6679356 0.789 rs3790567 chr1:67822377 A/G cg24364144 chr1:67875067 SERBP1 0.44 6.68 0.35 9.93e-11 Primary biliary cholangitis; CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg09920427 chr19:12777674 MORG1;MAN2B1 -0.53 -6.43 -0.33 4.54e-10 Diisocyanate-induced asthma; CRC cis rs6495122 0.699 rs12905199 chr15:75070196 A/G cg14664628 chr15:75095509 CSK -0.68 -11.01 -0.52 3.19e-24 Caffeine consumption;Diastolic blood pressure;Coffee consumption; CRC cis rs1165668 0.816 rs1866072 chr12:104310706 C/G cg21863207 chr12:104234989 NT5DC3 0.44 6.44 0.33 4.23e-10 Coronary heart disease (SNP X SNP interaction); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg07633598 chr16:84179194 LRRC50;HSDL1 0.42 6.06 0.32 3.64e-9 Intelligence (multi-trait analysis); CRC cis rs4727027 0.901 rs34201592 chr7:148842403 C/G cg23583168 chr7:148888333 NA -0.88 -14.83 -0.63 1.87e-38 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC cis rs6912958 0.559 rs446851 chr6:88043640 G/A cg04972856 chr6:88032051 C6orf162;GJB7 0.33 6.24 0.33 1.35e-9 Monocyte percentage of white cells; CRC cis rs9611565 0.659 rs12484228 chr22:41939739 A/G cg17554472 chr22:41940697 POLR3H -0.55 -5.98 -0.31 5.91e-9 Vitiligo; CRC cis rs6500602 0.648 rs7702 chr16:4560929 G/C cg08645402 chr16:4508243 NA 0.58 8.65 0.43 2.3e-16 Schizophrenia; CRC cis rs13118159 0.836 rs2293630 chr4:1342521 G/A cg20092199 chr4:1342459 KIAA1530 0.48 8.67 0.43 2e-16 Longevity; CRC cis rs6502050 0.835 rs8067138 chr17:80111026 T/C cg11859384 chr17:80120422 CCDC57 -0.37 -5.85 -0.31 1.16e-8 Life satisfaction; CRC trans rs57221529 0.766 rs12522303 chr5:555564 A/C cg11887960 chr12:57824829 NA 0.58 6.44 0.33 4.17e-10 Lung disease severity in cystic fibrosis; CRC cis rs7927771 0.542 rs11039336 chr11:47706141 A/G cg20307385 chr11:47447363 PSMC3 -0.48 -7.14 -0.37 5.92e-12 Subjective well-being; CRC cis rs35771425 0.509 rs3120782 chr1:211419700 A/T cg25617285 chr1:211431773 RCOR3 -0.39 -5.8 -0.3 1.52e-8 Educational attainment (years of education); CRC cis rs754466 0.580 rs1344966 chr10:79534527 T/C cg17075019 chr10:79541650 NA -0.97 -18.55 -0.72 4.41e-53 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs1552244 1.000 rs35741213 chr3:10087661 A/G cg02579736 chr3:10068473 FANCD2;CIDECP 1.02 13.77 0.6 2.25e-34 Alzheimer's disease; CRC trans rs887912 0.722 rs980183 chr2:59311536 A/G cg21870469 chr6:16238691 GMPR -0.53 -6.33 -0.33 8.22e-10 Hip circumference;Body mass index;Obesity; CRC cis rs10499694 0.933 rs12718583 chr7:50582631 T/C cg18232548 chr7:50535776 DDC -0.4 -6.03 -0.32 4.33e-9 Body mass index; CRC cis rs4563143 0.675 rs56293553 chr19:29270455 A/G cg14983838 chr19:29218262 NA 0.48 7.02 0.36 1.31e-11 Methadone dose in opioid dependence; CRC trans rs9650657 0.645 rs4841409 chr8:10516374 C/T cg06636001 chr8:8085503 FLJ10661 0.47 7.07 0.36 9.23e-12 Neuroticism; CRC cis rs2832191 0.765 rs2832162 chr21:30461808 G/A cg08807101 chr21:30365312 RNF160 0.65 10.21 0.49 1.85e-21 Dental caries; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg04360780 chr4:2010701 WHSC2 0.45 6.17 0.32 2.03e-9 Anxiety disorder; CRC cis rs3741151 0.764 rs7101561 chr11:73264219 G/C cg17517138 chr11:73019481 ARHGEF17 0.96 7.44 0.38 8.7e-13 GIP levels in response to oral glucose tolerance test (120 minutes); CRC cis rs4423214 0.840 rs2017686 chr11:71187061 C/G cg05163923 chr11:71159392 DHCR7 -0.63 -7.61 -0.39 2.92e-13 Vitamin D levels; CRC cis rs3617 0.572 rs2245538 chr3:52852060 T/C cg11645453 chr3:52864694 ITIH4 0.46 9.05 0.45 1.31e-17 Red blood cell count;Autism spectrum disorder or schizophrenia; CRC cis rs8077889 1.000 rs17742905 chr17:41891143 C/A cg26893861 chr17:41843967 DUSP3 0.96 12.73 0.57 1.87e-30 Triglycerides; CRC cis rs6908034 0.607 rs74559916 chr6:19818717 G/T cg02682789 chr6:19804855 NA 0.83 6.67 0.35 1.08e-10 Endometriosis;Deep ovarian and/or rectovaginal disease with dense adhesions; CRC cis rs1728785 0.901 rs8050289 chr16:68566976 T/A cg02972257 chr16:68554789 NA -0.57 -6.94 -0.36 2.11e-11 Ulcerative colitis; CRC cis rs3806843 1.000 rs3756342 chr5:140165624 G/A cg19875535 chr5:140030758 IK 0.6 9.79 0.47 5.14e-20 Depressive symptoms (multi-trait analysis); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg15066777 chr18:66382427 CCDC102B;TMX3 0.4 6.22 0.32 1.51e-9 Intelligence (multi-trait analysis); CRC cis rs2370759 1.000 rs11599044 chr10:32615445 A/G cg01819863 chr10:32635814 EPC1 1.14 13.65 0.6 6.42e-34 Sexual dysfunction (female); CRC cis rs2153535 0.580 rs1932280 chr6:8473654 G/A cg21535247 chr6:8435926 SLC35B3 0.49 7.4 0.38 1.17e-12 Motion sickness; CRC trans rs10982213 0.830 rs2274163 chr9:117188714 C/T cg13435101 chr6:74171350 MTO1 -0.42 -6.27 -0.33 1.15e-9 Interleukin-6 levels; CRC cis rs897984 0.568 rs67264578 chr16:30879395 G/A cg02466173 chr16:30829666 NA -0.67 -8.48 -0.42 7.94e-16 Dementia with Lewy bodies; CRC cis rs4523957 0.579 rs2307143 chr17:2089754 G/A cg16513277 chr17:2031491 SMG6 -0.59 -9.87 -0.48 2.66e-20 Autism spectrum disorder or schizophrenia;Schizophrenia; CRC cis rs4253772 0.515 rs6008591 chr22:46703664 T/C cg24881330 chr22:46731750 TRMU 0.63 7.12 0.37 6.99e-12 LDL cholesterol;Cholesterol, total; CRC cis rs703842 1.000 rs11172349 chr12:58212528 G/A cg00677455 chr12:58241039 CTDSP2 0.64 8.61 0.43 3.16e-16 Multiple sclerosis; CRC cis rs72781680 1.000 rs963725 chr2:24148231 T/C cg08917208 chr2:24149416 ATAD2B 1.03 10.1 0.49 4.66e-21 Lymphocyte counts; CRC cis rs12682352 0.602 rs1473029 chr8:8668917 A/C cg06636001 chr8:8085503 FLJ10661 0.54 8.41 0.42 1.26e-15 Neuroticism; CRC cis rs1552244 0.882 rs56332224 chr3:10037321 G/A cg16606324 chr3:10149918 C3orf24 0.64 8.41 0.42 1.23e-15 Alzheimer's disease; CRC cis rs17401966 0.931 rs4846213 chr1:10399178 A/G cg19773385 chr1:10388646 KIF1B -0.7 -11.31 -0.53 2.76e-25 Hepatocellular carcinoma; CRC trans rs9858542 0.953 rs7622302 chr3:49547561 T/C cg21659725 chr3:3221576 CRBN -0.66 -8.98 -0.44 2.18e-17 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs4731207 0.698 rs7793441 chr7:124536238 A/G cg23710748 chr7:124431027 NA -0.38 -6.06 -0.32 3.65e-9 Cutaneous malignant melanoma; CRC cis rs12701220 0.947 rs1007765 chr7:1032805 G/C cg26240231 chr7:1148101 C7orf50 -0.42 -5.67 -0.3 3.15e-8 Bronchopulmonary dysplasia; CRC cis rs9926296 0.682 rs258328 chr16:89730314 C/T cg03605463 chr16:89740564 NA 0.61 9.66 0.47 1.32e-19 Vitiligo; CRC cis rs9303401 0.614 rs66480139 chr17:57101538 G/A cg02118635 chr17:56770003 RAD51C;TEX14 0.69 8.79 0.44 8.51e-17 Cognitive test performance; CRC cis rs7223966 1.000 rs9901112 chr17:61730617 C/G cg05941027 chr17:61774174 LIMD2 0.36 6.43 0.33 4.56e-10 Hip circumference adjusted for BMI;Body mass index; CRC cis rs10493773 0.609 rs11161656 chr1:86182414 A/G cg23216685 chr1:86174607 ZNHIT6 -0.29 -6.73 -0.35 7.78e-11 Urate levels in overweight individuals; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg10139443 chr6:99963249 USP45 0.43 6.59 0.34 1.75e-10 Intelligence (multi-trait analysis); CRC cis rs1865760 0.516 rs10807007 chr6:26048931 A/C cg17691542 chr6:26056736 HIST1H1C 0.55 8.45 0.42 9.68e-16 Height; CRC cis rs734999 1.000 rs10797432 chr1:2501338 C/T cg18854424 chr1:2615690 NA 0.34 6.43 0.33 4.36e-10 Ulcerative colitis; CRC cis rs9814567 0.752 rs13084192 chr3:134336095 A/T cg06109529 chr3:134205091 CEP63;ANAPC13 0.67 9.83 0.48 3.66e-20 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs4925166 1 rs4925166 chr17:18210810 T/G cg08201673 chr17:18167551 SMCR7 0.42 6.68 0.35 1.03e-10 Multiple sclerosis; CRC cis rs1865760 0.516 rs9379819 chr6:26049819 A/C cg17691542 chr6:26056736 HIST1H1C 0.55 8.45 0.42 9.68e-16 Height; CRC cis rs13088645 0.652 rs13074557 chr3:134153526 G/C cg06109529 chr3:134205091 CEP63;ANAPC13 0.51 7.7 0.39 1.63e-13 Coronary artery disease; CRC cis rs2836633 0.929 rs11702165 chr21:40035313 C/T cg05519781 chr21:40033154 ERG 0.69 13.77 0.6 2.26e-34 Coronary artery disease; CRC cis rs739401 0.611 rs2301140 chr11:3022629 C/T cg05729581 chr11:3078854 CARS -0.53 -7.34 -0.38 1.66e-12 Longevity; CRC cis rs55823223 0.564 rs9894009 chr17:73850414 C/T cg08125733 chr17:73851984 WBP2 0.73 9.39 0.46 1.04e-18 Psoriasis; CRC cis rs6674176 0.935 rs4314918 chr1:44377503 G/A cg12908607 chr1:44402522 ARTN -0.54 -9.33 -0.46 1.6e-18 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Cognitive ability; CRC cis rs743757 0.878 rs1467913 chr3:50525017 G/T cg08207895 chr3:50388901 TUSC4;CYB561D2 0.42 6.09 0.32 3.08e-9 Diastolic blood pressure; CRC trans rs11722228 0.549 rs73212853 chr4:10096230 C/T cg26043149 chr18:55253948 FECH 1.14 17.42 0.69 1.34e-48 Gout;Urate levels;Serum uric acid levels; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg06815754 chr16:30905741 BCL7C 0.46 6.58 0.34 1.9e-10 Anxiety disorder; CRC cis rs11764590 0.715 rs55770986 chr7:2087823 T/C cg02825527 chr7:2087843 MAD1L1 -0.5 -6.06 -0.32 3.71e-9 Neuroticism; CRC cis rs694739 0.894 rs887314 chr11:64053157 T/G cg02228329 chr11:64053129 BAD;GPR137 0.61 8.75 0.43 1.11e-16 Alopecia areata;Crohn's disease;Psoriasis vulgaris; CRC cis rs34311866 0.808 rs11248060 chr4:964359 C/T cg07828340 chr4:882639 GAK 0.99 9.66 0.47 1.39e-19 Parkinson's disease; CRC cis rs28386778 0.700 rs11079515 chr17:62005645 C/G cg11494091 chr17:61959527 GH2 -0.66 -11.67 -0.54 1.4e-26 Prudent dietary pattern; CRC cis rs8072100 0.790 rs7222225 chr17:45693497 A/G cg08085267 chr17:45401833 C17orf57 0.56 8.44 0.42 1.04e-15 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC trans rs12495832 0.778 rs76104977 chr3:147930352 A/C cg10221266 chr7:153579447 NA 0.56 6.12 0.32 2.6e-9 Chin dimples; CRC cis rs898097 0.625 rs7406464 chr17:80891460 A/G cg15369054 chr17:80825471 TBCD 0.34 5.72 0.3 2.4e-8 Breast cancer; CRC cis rs9733 0.519 rs7521898 chr1:150707596 G/A cg18016565 chr1:150552671 MCL1 0.46 6.53 0.34 2.53e-10 Tonsillectomy; CRC cis rs7113874 0.589 rs7120065 chr11:8484896 C/T cg17679104 chr11:8615758 STK33 -0.35 -5.74 -0.3 2.17e-8 Body mass index in physically active individuals;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs9393777 0.513 rs9379907 chr6:26654318 C/T cg12292205 chr6:26970375 C6orf41 -0.61 -6.99 -0.36 1.52e-11 Intelligence (multi-trait analysis); CRC cis rs1863824 0.625 rs7091192 chr10:88167456 A/G cg07322936 chr10:88137208 NA -0.63 -8.66 -0.43 2.12e-16 Schizophrenia; CRC cis rs736408 0.608 rs6445534 chr3:52743384 G/A cg10802521 chr3:52805072 NEK4 -0.57 -8.97 -0.44 2.26e-17 Bipolar disorder; CRC cis rs898097 0.841 rs11656358 chr17:80853956 G/A cg03160526 chr17:80928410 B3GNTL1 -0.39 -5.72 -0.3 2.46e-8 Breast cancer; CRC cis rs6714710 0.603 rs11680321 chr2:98379267 C/T cg26665480 chr2:98280029 ACTR1B 0.5 6.94 0.36 2.05e-11 Posterior cortical atrophy and Alzheimer's disease; CRC cis rs10910092 1 rs10910092 chr1:2501516 A/G cg18854424 chr1:2615690 NA 0.32 6.05 0.32 3.84e-9 Ulcerative colitis; CRC cis rs992157 0.735 rs12990082 chr2:219102332 C/T cg00012203 chr2:219082015 ARPC2 0.62 10.33 0.49 7.46e-22 Colorectal cancer; CRC cis rs3733585 0.682 rs13124563 chr4:9927553 A/G cg00071950 chr4:10020882 SLC2A9 0.63 11.44 0.53 9.34e-26 Cleft plate (environmental tobacco smoke interaction); CRC cis rs7843479 0.965 rs1564305 chr8:21803816 A/C cg17168535 chr8:21777572 XPO7 0.56 9.08 0.45 9.96e-18 Mean corpuscular volume; CRC cis rs6076065 0.723 rs4815203 chr20:23395633 C/G cg11657817 chr20:23433608 CST11 0.43 6.33 0.33 8.11e-10 Facial morphology (factor 15, philtrum width); CRC cis rs2404602 1.000 rs2404740 chr15:76852143 C/T cg22467129 chr15:76604101 ETFA -0.44 -7.51 -0.38 5.61e-13 Blood metabolite levels; CRC cis rs1018836 0.632 rs7017630 chr8:91482604 A/G cg16814680 chr8:91681699 NA -0.63 -9.65 -0.47 1.47e-19 Ejection fraction in Tripanosoma cruzi seropositivity; CRC cis rs1949733 0.523 rs4619877 chr4:8543235 G/A cg11789530 chr4:8429930 ACOX3 -0.57 -7.73 -0.39 1.3e-13 Response to antineoplastic agents; CRC cis rs4563143 0.663 rs73025068 chr19:29238998 G/A cg12667521 chr19:29218732 NA 0.51 8.03 0.4 1.79e-14 Methadone dose in opioid dependence; CRC cis rs10540 1.000 rs61876335 chr11:488878 T/C cg03934478 chr11:495069 RNH1 0.68 8.08 0.41 1.26e-14 Body mass index; CRC cis rs60871478 0.545 rs35400476 chr7:795686 A/G cg04727924 chr7:799746 HEATR2 -0.43 -6.31 -0.33 9.23e-10 Cerebrospinal P-tau181p levels; CRC trans rs11098499 0.754 rs1814813 chr4:120258207 G/T cg25214090 chr10:38739885 LOC399744 -0.6 -9.68 -0.47 1.18e-19 Corneal astigmatism; CRC trans rs7267979 1.000 rs6083809 chr20:25329309 A/G cg17903999 chr18:56338584 MALT1 0.42 6.98 0.36 1.63e-11 Liver enzyme levels (alkaline phosphatase); CRC cis rs12325245 0.536 rs35908812 chr16:58587426 T/C cg01472538 chr16:58549086 SETD6 1.06 6.94 0.36 2.05e-11 Schizophrenia; CRC cis rs4664308 0.875 rs7593593 chr2:160933811 C/T cg03641300 chr2:160917029 PLA2R1 -0.73 -11.52 -0.54 5e-26 Idiopathic membranous nephropathy; CRC cis rs6424115 0.545 rs11576333 chr1:24065770 C/T cg15997130 chr1:24165203 NA -0.66 -8.36 -0.42 1.79e-15 Immature fraction of reticulocytes; CRC cis rs10504229 0.953 rs67886764 chr8:58187117 T/C cg02290350 chr8:58132656 NA -0.42 -5.96 -0.31 6.62e-9 Developmental language disorder (linguistic errors); CRC cis rs10256972 0.758 rs9801444 chr7:1080444 A/C cg16145915 chr7:1198662 ZFAND2A 0.29 5.65 0.3 3.49e-8 Longevity;Endometriosis; CRC cis rs6685188 0.920 rs10751444 chr1:205662144 A/G cg07167872 chr1:205819463 PM20D1 -0.43 -5.99 -0.31 5.37e-9 White blood cell count (basophil);Basophil percentage of white cells; CRC cis rs7809950 0.637 rs2701685 chr7:107299584 A/G cg23024343 chr7:107201750 COG5 0.6 8.56 0.43 4.29e-16 Coronary artery disease; CRC cis rs7552404 1.000 rs12127402 chr1:76205643 C/A cg03433033 chr1:76189801 ACADM 0.8 10.93 0.52 6.41e-24 Blood metabolite levels;Acylcarnitine levels; CRC cis rs9322193 0.923 rs9767652 chr6:150055638 A/T cg05861140 chr6:150128134 PCMT1 -0.38 -5.93 -0.31 7.58e-9 Lung cancer; CRC cis rs473651 0.935 rs559579 chr2:239339501 G/C cg21699342 chr2:239360505 ASB1 0.52 8.21 0.41 5.22e-15 Multiple system atrophy; CRC cis rs6121246 0.821 rs7265413 chr20:30317923 G/A cg13852791 chr20:30311386 BCL2L1 0.69 11.57 0.54 3.37e-26 Mean corpuscular hemoglobin; CRC trans rs1814175 0.645 rs7119101 chr11:49955665 G/A cg11707556 chr5:10655725 ANKRD33B -0.52 -10.05 -0.48 6.61e-21 Height; CRC cis rs6088590 1.000 rs6119524 chr20:33373813 C/T cg08999081 chr20:33150536 PIGU 0.51 8.5 0.42 6.91e-16 Coronary artery disease; CRC cis rs3764400 0.567 rs16951519 chr17:46152291 G/A cg10706073 chr17:46328419 SKAP1 -0.62 -6.71 -0.35 8.77e-11 Body mass index; CRC trans rs6601327 0.641 rs11780399 chr8:9589167 C/T cg06636001 chr8:8085503 FLJ10661 -0.5 -7.29 -0.37 2.34e-12 Multiple myeloma (hyperdiploidy); CRC trans rs2303319 0.504 rs12470743 chr2:162611202 G/A cg04551154 chr10:95462393 C10orf4 -0.75 -6.37 -0.33 6.43e-10 Cognitive function; CRC cis rs561341 0.941 rs501773 chr17:30314435 T/G cg19193384 chr17:30244184 NA -0.53 -6.67 -0.35 1.06e-10 Hip circumference adjusted for BMI; CRC cis rs7312933 0.934 rs11181289 chr12:42402342 C/T cg01256987 chr12:42539512 GXYLT1 -0.43 -6.4 -0.33 5.45e-10 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CRC cis rs1799949 1.000 rs8176269 chr17:41213626 G/T cg25072359 chr17:41440525 NA 0.46 6.75 0.35 6.69e-11 Menopause (age at onset); CRC cis rs9902453 0.967 rs4473252 chr17:28454423 G/C cg26525008 chr17:28256777 EFCAB5;SSH2 0.59 9.2 0.45 4.18e-18 Coffee consumption (cups per day); CRC cis rs7412746 0.611 rs1889741 chr1:150869045 T/C cg17724175 chr1:150552817 MCL1 0.39 6.0 0.31 5.11e-9 Melanoma; CRC trans rs10982213 0.830 rs2274163 chr9:117188714 C/T cg27367768 chr5:171615456 STK10 0.38 6.53 0.34 2.53e-10 Interleukin-6 levels; CRC cis rs7586879 1.000 rs7608185 chr2:25115432 G/C cg04586622 chr2:25135609 ADCY3 -0.43 -7.19 -0.37 4.46e-12 Body mass index; CRC cis rs10779751 1.000 rs4845982 chr1:11271576 T/C cg08854313 chr1:11322531 MTOR 0.64 9.11 0.45 8.22e-18 Body mass index; CRC cis rs9311474 1.000 rs6445358 chr3:52308845 C/G cg18099408 chr3:52552593 STAB1 -0.48 -7.95 -0.4 2.93e-14 Electroencephalogram traits; CRC cis rs9287719 0.810 rs1990612 chr2:10781944 A/G cg00105475 chr2:10696890 NA 0.44 7.0 0.36 1.45e-11 Prostate cancer; CRC cis rs10256972 0.516 rs12702081 chr7:1141528 T/C cg09177884 chr7:1199841 ZFAND2A -0.41 -5.95 -0.31 6.7e-9 Longevity;Endometriosis; CRC cis rs4561483 0.831 rs2075158 chr16:11945231 T/C cg08843971 chr16:11963173 GSPT1 0.61 8.94 0.44 2.77e-17 Testicular germ cell tumor; CRC cis rs1448094 0.512 rs11117061 chr12:86250916 G/A cg00310523 chr12:86230176 RASSF9 0.38 6.28 0.33 1.04e-9 Major depressive disorder; CRC cis rs1003719 0.762 rs2835590 chr21:38463406 A/G cg10648535 chr21:38446584 PIGP;TTC3 0.52 7.41 0.38 1.07e-12 Eye color traits; CRC cis rs853679 0.550 rs34477097 chr6:28197186 C/T cg25164649 chr6:28176230 NA 0.63 8.21 0.41 5.03e-15 Depression; CRC cis rs7605827 0.930 rs6761904 chr2:15599658 A/G cg19274914 chr2:15703543 NA 0.4 6.04 0.32 4.18e-9 Educational attainment (years of education); CRC cis rs801193 0.569 rs13242290 chr7:66121885 G/A cg12463550 chr7:65579703 CRCP -0.45 -5.94 -0.31 7.28e-9 Aortic root size; CRC cis rs1506636 1.000 rs652497 chr7:123423671 G/T cg03229431 chr7:123269106 ASB15 0.73 11.68 0.54 1.34e-26 Plateletcrit;Platelet count; CRC cis rs853679 0.527 rs707907 chr6:28291240 A/G cg06470822 chr6:28175283 NA 0.47 6.55 0.34 2.17e-10 Depression; CRC cis rs9914544 0.966 rs9906795 chr17:18816740 G/A cg26306683 chr17:18585705 ZNF286B 0.49 7.04 0.36 1.11e-11 Educational attainment (years of education); CRC trans rs12495832 0.778 rs74980258 chr3:147921660 G/A cg10221266 chr7:153579447 NA 0.56 6.13 0.32 2.54e-9 Chin dimples; CRC cis rs796364 0.951 rs13029537 chr2:200998950 T/C cg12253985 chr2:200820533 C2orf60;C2orf47 -0.56 -6.02 -0.31 4.73e-9 Schizophrenia; CRC cis rs2637266 0.549 rs11516640 chr10:78414532 A/G cg18941641 chr10:78392320 NA -0.34 -5.73 -0.3 2.32e-8 Pulmonary function; CRC cis rs3791406 1.000 rs3791406 chr2:240030484 A/G cg14550559 chr2:240039617 HDAC4 0.5 7.61 0.39 2.98e-13 Skin aging (microtopography measurement); CRC cis rs4853012 0.941 rs2421752 chr2:74341615 A/G cg19729930 chr2:74357872 NA 0.69 10.42 0.5 3.66e-22 Gestational age at birth (maternal effect); CRC cis rs4731207 0.597 rs12536017 chr7:124562301 A/G cg23710748 chr7:124431027 NA -0.38 -6.0 -0.31 5.32e-9 Cutaneous malignant melanoma; CRC trans rs2303319 0.504 rs16845945 chr2:162480684 C/T cg12500891 chr11:57225987 NA -0.68 -6.07 -0.32 3.49e-9 Cognitive function; CRC cis rs1129187 0.935 rs4987173 chr6:42931224 G/A cg02359409 chr6:42947317 PEX6 -0.57 -8.92 -0.44 3.24e-17 Alzheimer's disease in APOE e4+ carriers; CRC cis rs6952808 1.000 rs59248873 chr7:1888185 A/G cg02951883 chr7:2050386 MAD1L1 -0.67 -10.76 -0.51 2.55e-23 Bipolar disorder and schizophrenia; CRC trans rs7618501 1.000 rs7372730 chr3:49790682 C/G cg21582582 chr3:182698605 DCUN1D1 -0.57 -8.4 -0.42 1.38e-15 Intelligence (multi-trait analysis); CRC cis rs8044868 0.586 rs7190994 chr16:72099241 T/A cg06172871 chr16:72088244 HP 0.44 6.44 0.33 4.35e-10 Body mass index (change over time) in cancer or chronic obstructive pulmonary disease;Body mass index (change over time) in cancer; CRC cis rs524023 0.957 rs552307 chr11:64357539 G/A cg06522879 chr11:64358276 SLC22A12 0.57 8.89 0.44 4.04e-17 Urate levels in obese individuals; CRC cis rs7918232 0.941 rs1755399 chr10:27394958 A/G cg14240646 chr10:27532245 ACBD5 -0.82 -9.19 -0.45 4.62e-18 Breast cancer; CRC cis rs11190604 1.000 rs10883507 chr10:102291275 C/T cg07080220 chr10:102295463 HIF1AN 0.47 5.65 0.3 3.39e-8 Palmitoleic acid (16:1n-7) levels; CRC cis rs4713118 0.869 rs6901520 chr6:27714575 G/T cg12172441 chr6:28176163 NA 0.53 7.28 0.37 2.5e-12 Parkinson's disease; CRC cis rs1348850 0.598 rs1405717 chr2:178500101 G/T cg22681709 chr2:178499509 PDE11A -0.5 -9.25 -0.45 3e-18 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs2739330 0.731 rs2000468 chr22:24241611 G/T cg10150615 chr22:24372951 LOC391322 -0.56 -8.48 -0.42 7.57e-16 Liver enzyme levels (gamma-glutamyl transferase); CRC trans rs629535 0.773 rs630235 chr8:70033529 T/G cg21567404 chr3:27674614 NA 0.95 16.08 0.66 2.35e-43 Dupuytren's disease; CRC cis rs8141529 0.764 rs5752809 chr22:29225500 G/A cg15103426 chr22:29168792 CCDC117 0.59 8.61 0.43 3.05e-16 Lymphocyte counts; CRC cis rs8170 1.000 rs10406920 chr19:17389648 C/T cg04749549 chr19:17459798 NA -0.45 -6.11 -0.32 2.76e-9 Breast cancer (estrogen-receptor negative);Breast Cancer in BRCA1 mutation carriers;Ovarian cancer;Breast cancer;Epithelial ovarian cancer; CRC cis rs2404602 0.647 rs11633869 chr15:77133322 G/T cg03037974 chr15:76606532 NA 0.54 8.04 0.41 1.65e-14 Blood metabolite levels; CRC cis rs1448094 0.510 rs11117016 chr12:86141602 T/C cg02569458 chr12:86230093 RASSF9 -0.48 -8.01 -0.4 1.99e-14 Major depressive disorder; CRC cis rs881375 1.000 rs7037140 chr9:123656327 T/C cg09419670 chr9:123605666 PSMD5;LOC253039 0.6 8.8 0.44 7.95e-17 Rheumatoid arthritis; CRC cis rs17711722 0.522 rs6957759 chr7:65271785 A/G cg02869306 chr7:64672164 INTS4L1 -0.49 -8.38 -0.42 1.59e-15 Calcium levels; CRC cis rs17376456 1.000 rs34756085 chr5:93556294 A/G cg21475434 chr5:93447410 FAM172A 0.74 6.87 0.35 3.28e-11 Diabetic retinopathy; CRC cis rs75920871 0.528 rs11216245 chr11:116913202 C/T cg20608306 chr11:116969690 SIK3 -0.34 -6.41 -0.33 5.08e-10 Subjective well-being; CRC cis rs13191362 0.935 rs13212137 chr6:163010261 A/G cg21926612 chr6:163149169 PACRG;PARK2 0.78 10.8 0.51 1.77e-23 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs3824867 0.920 rs4752836 chr11:47465095 T/C cg05585544 chr11:47624801 NA -0.4 -6.34 -0.33 7.63e-10 Mean corpuscular hemoglobin; CRC cis rs7044106 0.791 rs735109 chr9:123488879 C/T cg09586646 chr9:123605570 PSMD5;LOC253039 0.66 9.73 0.47 7.96e-20 Hip circumference adjusted for BMI; CRC cis rs10193935 0.892 rs12622152 chr2:42482929 C/A cg27598129 chr2:42591480 NA -0.71 -8.08 -0.41 1.24e-14 Colonoscopy-negative controls vs population controls; CRC cis rs6783573 0.510 rs11718490 chr3:46628763 C/T cg21489266 chr3:46619131 LRRC2;TDGF1 -0.4 -5.84 -0.31 1.26e-8 Cerebrospinal fluid biomarker levels; CRC cis rs904251 0.504 rs2797795 chr6:37480683 T/C cg01843034 chr6:37503916 NA -0.44 -8.2 -0.41 5.61e-15 Cognitive performance; CRC cis rs9467711 0.606 rs9393718 chr6:26407482 G/A cg08501292 chr6:25962987 TRIM38 0.78 6.07 0.32 3.44e-9 Autism spectrum disorder or schizophrenia; CRC cis rs10751667 0.643 rs7395613 chr11:933873 C/T ch.11.42038R chr11:967971 AP2A2 0.6 10.26 0.49 1.35e-21 Alzheimer's disease (late onset); CRC cis rs877282 0.898 rs11253350 chr10:765968 G/A cg17470449 chr10:769945 NA 0.64 8.08 0.41 1.28e-14 Uric acid levels; CRC cis rs12477438 0.520 rs2969379 chr2:99776686 G/A cg26064155 chr2:99771622 LIPT1;TSGA10 0.88 16.24 0.67 5.59e-44 Chronic sinus infection; CRC cis rs853679 0.517 rs9393884 chr6:28046789 A/G cg12172441 chr6:28176163 NA 0.58 7.01 0.36 1.37e-11 Depression; CRC cis rs13082711 0.595 rs17681498 chr3:27331258 T/C cg02860705 chr3:27208620 NA 0.82 10.82 0.51 1.5e-23 Systolic blood pressure;Diastolic blood pressure;Blood pressure; CRC cis rs7044106 0.791 rs10739572 chr9:123489815 C/T cg14255062 chr9:123606675 PSMD5;LOC253039 0.49 7.42 0.38 9.99e-13 Hip circumference adjusted for BMI; CRC trans rs13046373 0.905 rs4816372 chr21:32077414 A/T cg03819338 chr20:39942766 NA -0.35 -6.1 -0.32 3.01e-9 HDL cholesterol; CRC cis rs1348850 0.645 rs10181259 chr2:178428256 C/A cg27490568 chr2:178487706 NA 0.44 5.66 0.3 3.3e-8 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs6604026 0.524 rs532834 chr1:93468062 A/T cg17283838 chr1:93427260 FAM69A 0.47 6.5 0.34 2.97e-10 Multiple sclerosis; CRC cis rs6748734 0.600 rs10202620 chr2:241820912 G/C cg16358738 chr2:241808595 AGXT -0.41 -7.26 -0.37 2.76e-12 Urinary metabolites; CRC cis rs7124681 0.584 rs10769285 chr11:47709212 C/T cg20307385 chr11:47447363 PSMC3 0.46 6.7 0.35 8.98e-11 Body mass index (joint analysis main effects and physical activity interaction);Body mass index;Body mass index in physically active individuals; CRC trans rs2303319 0.504 rs35304298 chr2:162617185 G/T cg25193742 chr10:104614220 C10orf32 -0.76 -6.46 -0.34 3.66e-10 Cognitive function; CRC cis rs4750440 0.706 rs12358733 chr10:14016290 A/G cg00551146 chr10:14014579 FRMD4A -0.36 -5.95 -0.31 6.76e-9 Adiponectin levels; CRC cis rs847577 0.677 rs10242903 chr7:97741795 C/T cg21770322 chr7:97807741 LMTK2 -0.66 -12.04 -0.55 6.29e-28 Breast cancer; CRC cis rs7086627 0.515 rs4934189 chr10:82214792 C/T cg09626299 chr10:82213104 TSPAN14 -0.37 -6.2 -0.32 1.71e-9 Post bronchodilator FEV1; CRC cis rs875971 1.000 rs1144894 chr7:65542894 A/G cg18912574 chr7:65842487 NCRNA00174 -0.37 -6.32 -0.33 8.29e-10 Aortic root size; CRC cis rs1707322 0.691 rs61784803 chr1:46179271 C/A cg03146154 chr1:46216737 IPP -0.68 -9.94 -0.48 1.59e-20 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs1401999 0.628 rs1520195 chr3:183736882 G/A cg05044414 chr3:183734942 ABCC5 0.42 7.45 0.38 8.42e-13 Anterior chamber depth; CRC cis rs796364 1.000 rs281794 chr2:200846666 C/T cg23649088 chr2:200775458 C2orf69 0.54 5.8 0.3 1.58e-8 Schizophrenia; CRC cis rs9611519 0.929 rs9611469 chr22:41433319 T/C cg03806693 chr22:41940476 POLR3H -0.55 -6.96 -0.36 1.81e-11 Neuroticism; CRC trans rs2303319 0.504 rs62188984 chr2:162514518 G/A cg18122310 chr12:50236657 BCDIN3D -0.74 -6.19 -0.32 1.81e-9 Cognitive function; CRC cis rs4819052 0.851 rs10470246 chr21:46659017 C/G cg11663144 chr21:46675770 NA -0.8 -13.38 -0.59 6.77e-33 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs3015497 0.608 rs3015499 chr14:51112460 T/C cg26011998 chr14:51135199 SAV1 -0.44 -5.67 -0.3 3.08e-8 Mean platelet volume; CRC cis rs2836950 0.565 rs2836943 chr21:40592611 C/T cg11644478 chr21:40555479 PSMG1 -0.51 -7.61 -0.39 2.86e-13 Menarche (age at onset); CRC cis rs12477438 0.501 rs9941561 chr2:99753829 A/C cg14399236 chr2:99771627 LIPT1;TSGA10 0.79 13.62 0.6 8.2e-34 Chronic sinus infection; CRC cis rs6951245 1.000 rs11767527 chr7:1097394 T/C cg18402987 chr7:1209562 NA 0.67 7.17 0.37 5.02e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs7208859 0.573 rs79505916 chr17:29062326 C/T cg13385521 chr17:29058706 SUZ12P 0.71 7.95 0.4 3.07e-14 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs1799949 0.965 rs12947782 chr17:41279882 A/G cg19454999 chr17:41278357 BRCA1;NBR2 0.55 8.63 0.43 2.68e-16 Menopause (age at onset); CRC cis rs76419734 0.510 rs12504088 chr4:106662004 A/G cg24545054 chr4:106630052 GSTCD;INTS12 0.61 7.51 0.38 5.72e-13 Post bronchodilator FEV1; CRC cis rs9649213 0.593 rs6465667 chr7:97957885 G/A cg08684580 chr7:98029266 BAIAP2L1 -0.32 -5.65 -0.3 3.44e-8 Prostate cancer (SNP x SNP interaction); CRC cis rs17253792 0.822 rs10483650 chr14:56145312 A/G cg01858014 chr14:56050164 KTN1 -0.88 -7.22 -0.37 3.55e-12 Putamen volume; CRC cis rs5753618 0.583 rs5753639 chr22:31870400 A/G cg02404636 chr22:31891804 SFI1 -0.44 -5.97 -0.31 6.24e-9 Colorectal cancer; CRC cis rs7264396 0.832 rs224381 chr20:34097136 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.43 -7.13 -0.37 6.49e-12 Total cholesterol levels; CRC cis rs7772486 0.754 rs6921073 chr6:146144377 G/A cg23711669 chr6:146136114 FBXO30 0.67 11.19 0.53 7.47e-25 Lobe attachment (rater-scored or self-reported); CRC cis rs736408 0.634 rs11717836 chr3:52807736 A/G cg07507251 chr3:52567010 NT5DC2 0.46 6.47 0.34 3.54e-10 Bipolar disorder; CRC cis rs67311347 0.955 rs73078170 chr3:40483947 C/T cg24209194 chr3:40518798 ZNF619 0.42 6.01 0.31 5.02e-9 Renal cell carcinoma; CRC cis rs28374715 0.532 rs7164211 chr15:41705041 A/T cg18705301 chr15:41695430 NDUFAF1 -1.06 -19.17 -0.73 1.63e-55 Ulcerative colitis; CRC cis rs7894407 0.892 rs10883859 chr10:105128134 T/G cg05636881 chr10:105038444 INA -0.37 -5.83 -0.31 1.33e-8 White matter hyperintensity burden; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg12346351 chr4:152330392 FAM160A1 0.49 7.18 0.37 4.61e-12 Response to antipsychotic treatment; CRC cis rs9527 0.590 rs10883839 chr10:104920341 A/G cg04362960 chr10:104952993 NT5C2 0.6 8.25 0.41 3.9e-15 Arsenic metabolism; CRC cis rs13108904 0.935 rs13148614 chr4:1248357 G/C cg20887711 chr4:1340912 KIAA1530 0.43 6.06 0.32 3.78e-9 Obesity-related traits; CRC cis rs870825 0.616 rs6825561 chr4:185615532 A/T cg04058563 chr4:185651563 MLF1IP 0.72 9.21 0.45 3.89e-18 Blood protein levels; CRC cis rs7945705 0.714 rs2653570 chr11:8987823 A/G cg00186954 chr11:8933980 ST5;C11orf17 -0.46 -7.77 -0.39 9.87e-14 Hemoglobin concentration; CRC cis rs6860806 0.661 rs2136188 chr5:131577514 A/G cg12564285 chr5:131593104 PDLIM4 -0.5 -9.72 -0.47 8.34e-20 Breast cancer; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg17482927 chr17:63133259 RGS9 0.48 7.21 0.37 3.78e-12 Response to antipsychotic treatment; CRC cis rs9747201 0.925 rs7209621 chr17:80057099 C/T cg02741985 chr17:80059408 CCDC57 -0.44 -5.74 -0.3 2.11e-8 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs317689 0.608 rs650198 chr12:69674595 C/T cg20891283 chr12:69753455 YEATS4 0.45 5.97 0.31 6.11e-9 Response to diuretic therapy; CRC cis rs477895 0.653 rs2015226 chr11:63902534 C/T cg23719950 chr11:63933701 MACROD1 -0.65 -8.25 -0.41 3.82e-15 Mean platelet volume; CRC cis rs7591163 1.000 rs7574255 chr2:228699884 C/G cg08034379 chr2:228736324 WDR69 0.52 6.94 0.36 2.09e-11 Blood pressure; CRC cis rs4819052 0.851 rs35871601 chr21:46675214 C/T cg02159808 chr21:46707872 POFUT2;LOC642852 0.53 6.93 0.36 2.17e-11 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC trans rs6951245 0.872 rs74360401 chr7:1067403 G/A cg13565492 chr6:43139072 SRF -0.71 -7.31 -0.37 2.04e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs17270561 0.609 rs7769908 chr6:25760539 G/A cg17691542 chr6:26056736 HIST1H1C 0.64 8.14 0.41 8.02e-15 Iron status biomarkers; CRC cis rs4285028 0.948 rs12488334 chr3:121702526 T/C cg20356878 chr3:121714668 ILDR1 -0.47 -6.91 -0.36 2.59e-11 Multiple sclerosis; CRC cis rs7224685 0.906 rs9915922 chr17:4083242 T/C cg09695851 chr17:3907499 NA 0.43 6.07 0.32 3.46e-9 Type 2 diabetes; CRC cis rs9457247 0.765 rs9459849 chr6:167444160 G/T cg07741184 chr6:167504864 NA 0.39 6.75 0.35 6.7e-11 Crohn's disease; CRC cis rs853679 0.517 rs9283884 chr6:28135660 C/G cg15786705 chr6:28176104 NA -0.77 -9.53 -0.46 3.68e-19 Depression; CRC cis rs8177253 0.965 rs3811658 chr3:133476852 C/T cg16262614 chr3:133464971 TF 0.34 6.04 0.32 4.15e-9 Iron status biomarkers; CRC trans rs2303319 0.504 rs1567420 chr2:162475601 C/T cg12500891 chr11:57225987 NA 0.66 6.0 0.31 5.3e-9 Cognitive function; CRC trans rs61931739 0.500 rs12367292 chr12:33998075 T/C cg26384229 chr12:38710491 ALG10B 0.52 6.53 0.34 2.52e-10 Morning vs. evening chronotype; CRC cis rs7829975 0.539 rs940031 chr8:8546848 C/T cg06636001 chr8:8085503 FLJ10661 -0.47 -6.79 -0.35 5.18e-11 Mood instability; CRC cis rs3733585 0.699 rs4588456 chr4:9963895 A/T cg11266682 chr4:10021025 SLC2A9 -0.47 -9.67 -0.47 1.2e-19 Cleft plate (environmental tobacco smoke interaction); CRC cis rs9649213 0.593 rs3801256 chr7:97992095 C/G cg24562669 chr7:97807699 LMTK2 0.44 7.29 0.37 2.39e-12 Prostate cancer (SNP x SNP interaction); CRC cis rs28386778 0.897 rs4968662 chr17:61834537 A/G cg06873352 chr17:61820015 STRADA 0.76 14.29 0.62 2.25e-36 Prudent dietary pattern; CRC cis rs796364 1.000 rs281788 chr2:200783705 A/T cg25936922 chr2:200820526 C2orf60;C2orf47 0.7 7.66 0.39 2.1e-13 Schizophrenia; CRC cis rs2479724 0.811 rs8393 chr6:41757836 C/A cg17623882 chr6:41773611 USP49 0.52 8.62 0.43 2.87e-16 Menarche (age at onset); CRC cis rs12541635 0.677 rs7460291 chr8:107057861 A/G cg10147462 chr8:107024639 NA 0.6 10.5 0.5 2.01e-22 Age of smoking initiation; CRC cis rs7412746 0.658 rs12097963 chr1:150870450 T/C cg18016565 chr1:150552671 MCL1 0.41 5.78 0.3 1.73e-8 Melanoma; CRC cis rs13082711 0.554 rs6804440 chr3:27398150 C/T cg02860705 chr3:27208620 NA 0.85 10.92 0.52 6.59e-24 Systolic blood pressure;Diastolic blood pressure;Blood pressure; CRC cis rs12594515 1.000 rs12911309 chr15:45985719 G/C cg19682013 chr15:45996608 NA 0.32 6.62 0.34 1.48e-10 Waist circumference;Weight; CRC cis rs7772486 0.875 rs9390371 chr6:146363180 A/G cg23711669 chr6:146136114 FBXO30 0.62 10.57 0.5 1.11e-22 Lobe attachment (rater-scored or self-reported); CRC cis rs2857891 0.695 rs2346002 chr11:6987741 T/C cg22096450 chr11:6947773 ZNF215 0.48 5.72 0.3 2.35e-8 Response to cytadine analogues (cytosine arabinoside); CRC trans rs10242455 0.702 rs73711294 chr7:99088714 G/A cg09045935 chr12:6379348 NA 1.08 7.75 0.39 1.14e-13 Blood metabolite levels; CRC cis rs9891119 1.000 rs9891119 chr17:40507980 A/C cg06270615 chr17:40516068 STAT3 -0.26 -5.64 -0.3 3.7e-8 Multiple sclerosis;Crohn's disease; CRC cis rs2836974 0.932 rs2836955 chr21:40619887 G/A cg06238570 chr21:40685208 BRWD1 0.75 10.22 0.49 1.75e-21 Cognitive function; CRC cis rs780096 0.526 rs780112 chr2:27665361 C/G cg12000995 chr2:27665139 KRTCAP3 -0.32 -6.71 -0.35 8.61e-11 Total body bone mineral density; CRC cis rs7932354 0.528 rs4752967 chr11:47169376 T/C cg19486271 chr11:47235900 DDB2 0.43 6.42 0.33 4.89e-10 Bone mineral density (hip);Bone mineral density; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg03771185 chr4:775700 NA 0.53 7.01 0.36 1.33e-11 Thyroid stimulating hormone; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg21512275 chr2:157198069 NA 0.51 6.73 0.35 7.47e-11 Thyroid stimulating hormone; CRC cis rs9322193 0.962 rs6914319 chr6:150127440 G/A cg07701084 chr6:150067640 NUP43 0.47 6.61 0.34 1.51e-10 Lung cancer; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg19941686 chr7:23221979 NUPL2 0.42 5.99 0.31 5.61e-9 Response to antipsychotic treatment; CRC cis rs35883536 0.647 rs10875315 chr1:101044062 G/A cg06223162 chr1:101003688 GPR88 -0.36 -6.66 -0.34 1.12e-10 Monocyte count; CRC cis rs7552404 0.855 rs385897 chr1:76106962 T/C cg22875332 chr1:76189707 ACADM -0.67 -9.0 -0.44 1.87e-17 Blood metabolite levels;Acylcarnitine levels; CRC cis rs798554 0.704 rs709282 chr7:2769921 G/A cg13628971 chr7:2884303 GNA12 0.44 6.79 0.35 5.26e-11 Height; CRC trans rs2303319 0.504 rs12467613 chr2:162603216 G/T cg22922770 chr7:98923339 ARPC1A -0.67 -5.98 -0.31 5.68e-9 Cognitive function; CRC trans rs916888 0.647 rs199523 chr17:44848517 C/A cg07870213 chr5:140052090 DND1 -0.63 -8.2 -0.41 5.64e-15 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs7666738 0.830 rs62321565 chr4:98976571 G/A cg17366294 chr4:99064904 C4orf37 0.44 7.32 0.37 1.94e-12 Colonoscopy-negative controls vs population controls; CRC cis rs7666738 0.830 rs6832209 chr4:98994120 A/G cg17366294 chr4:99064904 C4orf37 0.43 7.27 0.37 2.66e-12 Colonoscopy-negative controls vs population controls; CRC cis rs3862030 0.720 rs11191295 chr10:104231054 A/G cg11453585 chr10:104263688 ACTR1A;SUFU -0.76 -13.31 -0.59 1.26e-32 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for body mass index; CRC cis rs7937682 0.575 rs34558891 chr11:111737912 C/T cg19812747 chr11:111475976 SIK2 0.43 6.29 0.33 1.03e-9 Primary sclerosing cholangitis; CRC cis rs514406 0.861 rs7524476 chr1:53240212 C/T cg25767906 chr1:53392781 SCP2 0.45 7.22 0.37 3.54e-12 Monocyte count; CRC cis rs11625487 0.505 rs10145609 chr14:77957377 G/A cg20045696 chr14:77926864 AHSA1 -0.42 -5.9 -0.31 8.92e-9 Neutrophil percentage of white cells;Sum neutrophil eosinophil counts;Neutrophil count; CRC cis rs6088590 1.000 rs6119516 chr20:33328024 C/T cg24642439 chr20:33292090 TP53INP2 0.6 10.82 0.51 1.58e-23 Coronary artery disease; CRC cis rs4481887 1.000 rs6659039 chr1:248465689 C/T cg13385794 chr1:248469461 NA 0.39 6.91 0.36 2.51e-11 Common traits (Other); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg12996417 chr4:152198109 PRSS48 0.42 6.9 0.36 2.65e-11 Liver disease severity in Alagille syndrome; CRC cis rs6754459 0.666 rs11674266 chr2:3705291 A/G cg19052272 chr2:3704530 ALLC -0.47 -6.7 -0.35 9.01e-11 Response to inhaled corticosteroid treatment in asthma (change in FEV1); CRC cis rs6952808 0.608 rs6461049 chr7:2017445 C/T cg04267008 chr7:1944627 MAD1L1 0.54 7.86 0.4 5.51e-14 Bipolar disorder and schizophrenia; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg23031969 chr7:5014415 RNF216L 0.44 7.07 0.36 9.17e-12 Liver disease severity in Alagille syndrome; CRC cis rs1218582 0.772 rs7528532 chr1:154874440 C/T cg09359103 chr1:154839909 KCNN3 -0.71 -12.5 -0.57 1.33e-29 Prostate cancer; CRC trans rs3960554 0.808 rs111764601 chr7:75706141 T/C cg19862616 chr7:65841803 NCRNA00174 0.73 8.61 0.43 3.13e-16 Eotaxin levels; CRC cis rs651907 0.535 rs11716558 chr3:101528481 T/C cg12386194 chr3:101231763 SENP7 0.52 7.45 0.38 8.46e-13 Colorectal cancer; CRC trans rs9858542 0.953 rs4625 chr3:49572140 A/G cg21665057 chr3:196295764 WDR53;FBXO45 -0.67 -9.17 -0.45 5.12e-18 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs62408225 0.722 rs3734660 chr6:90916345 A/G cg06866423 chr6:90926672 BACH2 0.65 12.04 0.55 6.69e-28 Eosinophil counts;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC cis rs11148252 0.774 rs6561666 chr13:52930045 A/G cg02158880 chr13:53174818 NA 0.47 7.1 0.36 7.9e-12 Lewy body disease; CRC cis rs10971721 0.731 rs10971782 chr9:33909464 C/T cg13495928 chr9:33750294 PRSS3 0.56 5.97 0.31 6.15e-9 Body mass index; CRC trans rs11039798 0.764 rs1121450 chr11:48897476 C/T cg03929089 chr4:120376271 NA 0.64 6.05 0.32 3.97e-9 Axial length; CRC cis rs7809950 1.000 rs2520265 chr7:107181231 A/G cg23024343 chr7:107201750 COG5 -0.62 -8.74 -0.43 1.18e-16 Coronary artery disease; CRC cis rs939584 0.877 rs13027828 chr2:632379 T/G cg03610516 chr2:642275 NA 0.42 5.64 0.3 3.58e-8 Body mass index; CRC cis rs9649213 0.574 rs36099592 chr7:98002331 T/C cg24562669 chr7:97807699 LMTK2 0.44 7.32 0.37 1.97e-12 Prostate cancer (SNP x SNP interaction); CRC cis rs10089 1.000 rs7713877 chr5:127428825 G/T cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.76 10.71 0.51 3.54e-23 Ileal carcinoids; CRC cis rs12580194 0.593 rs67934812 chr12:55785591 T/G cg23425280 chr12:56401806 NA 0.47 5.71 0.3 2.53e-8 Cancer; CRC cis rs2227564 0.678 rs2242257 chr10:75597605 A/G cg16540259 chr10:75572220 NDST2 -0.47 -6.66 -0.34 1.12e-10 Crohn's disease;Inflammatory bowel disease; CRC trans rs2243480 1.000 rs34577383 chr7:65385726 C/T cg10756647 chr7:56101905 PSPH 0.73 8.07 0.41 1.36e-14 Diabetic kidney disease; CRC trans rs12639288 0.962 rs12638639 chr3:167660757 C/T cg06028048 chr5:175815674 HIGD2A;NOP16 -0.52 -6.02 -0.31 4.71e-9 Hirschsprung disease; CRC cis rs939658 0.683 rs11634726 chr15:79465894 A/G cg17916960 chr15:79447300 NA -0.43 -6.97 -0.36 1.73e-11 Refractive error; CRC cis rs2455601 0.638 rs11042148 chr11:9008674 A/G cg21881798 chr11:8931708 C11orf17;ST5 -0.53 -6.11 -0.32 2.83e-9 Schizophrenia; CRC cis rs17023223 0.537 rs2645292 chr1:119573194 C/T cg05756136 chr1:119680316 WARS2 -0.47 -6.38 -0.33 5.84e-10 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for BMI in active individuals; CRC cis rs1008375 1.000 rs10939742 chr4:17659936 G/T cg04450456 chr4:17643702 FAM184B 0.41 6.65 0.34 1.25e-10 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs28386778 0.901 rs2854194 chr17:61952110 T/G cg23090583 chr17:61904693 PSMC5;FTSJ3 1.02 19.41 0.73 1.76e-56 Prudent dietary pattern; CRC cis rs6546550 0.901 rs13015457 chr2:70125763 G/T cg02498382 chr2:70120550 SNRNP27 -0.56 -9.59 -0.47 2.36e-19 Prevalent atrial fibrillation; CRC cis rs3750082 1.000 rs3750082 chr7:32919927 T/A cg05721444 chr7:32995514 FKBP9 0.42 5.98 0.31 5.97e-9 Glomerular filtration rate (creatinine); CRC cis rs7216064 1.000 rs8067892 chr17:65837983 A/G cg12091567 chr17:66097778 LOC651250 -0.63 -7.95 -0.4 3.08e-14 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CRC cis rs7224737 1.000 rs9903204 chr17:40288062 G/A cg20291162 chr17:40259547 DHX58 -0.55 -8.1 -0.41 1.06e-14 Fibrinogen levels; CRC cis rs7613875 0.580 rs12634780 chr3:50043341 A/T cg24308560 chr3:49941425 MST1R 0.43 6.78 0.35 5.65e-11 Body mass index; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg20617676 chr7:123389167 WASL 0.45 7.78 0.39 9.23e-14 Liver disease severity in Alagille syndrome; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg06433995 chr6:13615570 NOL7 0.47 6.73 0.35 7.6e-11 Response to antipsychotic treatment; CRC cis rs739401 0.595 rs402806 chr11:3066432 A/G cg08508325 chr11:3079039 CARS -0.49 -8.51 -0.42 6.37e-16 Longevity; CRC cis rs1005277 0.540 rs2474598 chr10:38430296 C/T cg17219203 chr10:38645113 HSD17B7P2 0.41 5.69 0.3 2.85e-8 Extrinsic epigenetic age acceleration; CRC cis rs7246657 0.943 rs13343502 chr19:37962292 C/T cg23950597 chr19:37808831 NA -0.54 -6.48 -0.34 3.42e-10 Coronary artery calcification; CRC cis rs2230307 0.536 rs560659 chr1:100523536 A/G cg24955406 chr1:100503596 HIAT1 -0.59 -7.22 -0.37 3.67e-12 Carotid intima media thickness; CRC cis rs9488822 0.702 rs6909746 chr6:116352750 C/T cg05304507 chr6:116381966 FRK 0.31 8.57 0.43 4.03e-16 Cholesterol, total;LDL cholesterol; CRC cis rs7692995 1.000 rs7694806 chr4:18029100 C/T cg08925142 chr4:18023851 LCORL -0.51 -5.75 -0.3 2.04e-8 Height; CRC cis rs1218582 0.744 rs6674853 chr1:154892753 G/C cg09359103 chr1:154839909 KCNN3 -0.74 -12.16 -0.56 2.3e-28 Prostate cancer; CRC cis rs9326248 0.813 rs474488 chr11:117068977 A/G cg11861562 chr11:117069780 TAGLN 0.33 6.2 0.32 1.71e-9 Blood protein levels; CRC cis rs2050392 0.928 rs2250077 chr10:30702929 A/G cg18806716 chr10:30721971 MAP3K8 -0.49 -7.41 -0.38 1.07e-12 Inflammatory bowel disease; CRC cis rs9311474 0.569 rs7614981 chr3:52566914 G/T cg01758942 chr3:52551074 STAB1 0.31 6.15 0.32 2.28e-9 Electroencephalogram traits; CRC trans rs208520 0.690 rs851458 chr6:66813279 T/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.08 -15.42 -0.65 9.04e-41 Exhaled nitric oxide output; CRC trans rs7618501 0.633 rs4688758 chr3:50028385 G/A cg21665057 chr3:196295764 WDR53;FBXO45 0.61 9.54 0.47 3.33e-19 Intelligence (multi-trait analysis); CRC cis rs7618915 0.571 rs12632381 chr3:52607685 G/A cg10802521 chr3:52805072 NEK4 -0.59 -9.05 -0.45 1.33e-17 Bipolar disorder; CRC cis rs17227506 0.730 rs35380952 chr8:13457292 G/A cg03566418 chr8:13424080 C8orf48 0.39 6.36 0.33 6.56e-10 Nonsyndromic cleft lip with cleft palate; CRC cis rs501120 0.850 rs642222 chr10:44770473 A/G cg09554077 chr10:44749378 NA 0.78 11.91 0.55 1.96e-27 Coronary artery disease;Coronary heart disease; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg27054308 chr14:20922865 APEX1;OSGEP 0.44 6.56 0.34 2.07e-10 Intelligence (multi-trait analysis); CRC cis rs12701220 0.894 rs34712249 chr7:1036634 C/T cg00990874 chr7:1149470 C7orf50 -0.58 -6.86 -0.35 3.45e-11 Bronchopulmonary dysplasia; CRC cis rs2580764 0.541 rs2968786 chr2:55264859 C/G cg09592903 chr2:55203963 RTN4 0.63 10.43 0.5 3.34e-22 Mean platelet volume; CRC cis rs1336900 0.641 rs6587756 chr1:150546865 A/T cg10589385 chr1:150898437 SETDB1 -0.31 -6.46 -0.34 3.76e-10 Blood protein levels; CRC cis rs7772486 0.720 rs6901888 chr6:146023144 A/G cg13319975 chr6:146136371 FBXO30 0.45 6.58 0.34 1.84e-10 Lobe attachment (rater-scored or self-reported); CRC cis rs9443645 0.901 rs9448596 chr6:79629429 T/C cg09184832 chr6:79620586 NA -0.49 -9.0 -0.44 1.83e-17 Intelligence (multi-trait analysis); CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg20393609 chr7:102105195 ALKBH4;LRWD1 0.45 6.45 0.34 4.05e-10 Anxiety disorder; CRC cis rs939584 1.000 rs10172769 chr2:646345 G/A cg03610516 chr2:642275 NA 0.42 5.88 0.31 9.94e-9 Body mass index; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg16140449 chr1:178511703 C1orf220 0.48 6.62 0.34 1.46e-10 Response to antipsychotic treatment; CRC cis rs6456156 0.586 rs12198816 chr6:167483546 G/A cg07741184 chr6:167504864 NA 0.41 6.88 0.35 2.98e-11 Primary biliary cholangitis; CRC cis rs4664293 0.903 rs10185155 chr2:160553228 G/A cg08347373 chr2:160653686 CD302 -0.46 -7.41 -0.38 1.09e-12 Monocyte percentage of white cells; CRC trans rs9858542 1.000 rs9882740 chr3:49702484 T/C cg21665057 chr3:196295764 WDR53;FBXO45 -0.66 -8.65 -0.43 2.32e-16 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs7945705 0.818 rs4929916 chr11:8824996 C/T cg21881798 chr11:8931708 C11orf17;ST5 0.55 8.79 0.44 8.59e-17 Hemoglobin concentration; CRC cis rs7412746 0.658 rs59024312 chr1:150909005 T/G cg18016565 chr1:150552671 MCL1 0.42 6.06 0.32 3.8e-9 Melanoma; CRC cis rs372883 0.600 rs1153276 chr21:30661694 T/C cg24692254 chr21:30365293 RNF160 -0.65 -9.67 -0.47 1.24e-19 Pancreatic cancer; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg25515063 chr12:121019412 POP5 0.44 6.2 0.32 1.74e-9 Response to antipsychotic treatment; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg13219625 chr3:49823913 IP6K1 -0.39 -6.09 -0.32 3.07e-9 Myopia (pathological); CRC cis rs6681460 0.966 rs10889642 chr1:67143334 T/G cg02459107 chr1:67143332 SGIP1 0.49 8.8 0.44 7.89e-17 Presence of antiphospholipid antibodies; CRC cis rs11723261 0.664 rs4627799 chr4:132389 C/T cg12746427 chr4:53362 ZNF718;ZNF595 0.48 6.77 0.35 6.05e-11 Immune response to smallpox vaccine (IL-6); CRC cis rs798554 0.660 rs798480 chr7:2805597 G/T cg19717773 chr7:2847554 GNA12 -0.46 -7.47 -0.38 7.49e-13 Height; CRC cis rs12313068 0.656 rs41436646 chr12:110495171 C/G cg12870014 chr12:110450643 ANKRD13A 0.82 12.4 0.56 3.13e-29 Intelligence (multi-trait analysis); CRC cis rs1707322 0.721 rs61784800 chr1:46178112 A/G cg03146154 chr1:46216737 IPP -0.64 -9.31 -0.46 1.85e-18 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs2976388 0.524 rs7012804 chr8:143844650 A/G cg20041105 chr8:143859282 LYNX1 0.58 10.6 0.5 9.17e-23 Urinary tract infection frequency; CRC cis rs7493 0.755 rs116306774 chr7:95016976 G/A cg17330251 chr7:94953956 PON1 -0.54 -6.78 -0.35 5.59e-11 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs7095944 0.554 rs11245344 chr10:126418782 C/T cg08799069 chr10:126477246 METTL10 -0.49 -7.82 -0.4 7.14e-14 Asthma; CRC cis rs3806843 0.966 rs2563267 chr5:140136913 C/T cg16607685 chr5:140181889 PCDHA2;PCDHA1;PCDHA3 0.25 5.91 0.31 8.7e-9 Depressive symptoms (multi-trait analysis); CRC cis rs2354432 0.607 rs11579626 chr1:146741960 A/C cg25205988 chr1:146714368 CHD1L -1.24 -9.92 -0.48 1.84e-20 Mitochondrial DNA levels; CRC cis rs7618915 0.547 rs34610878 chr3:52759169 G/C cg11645453 chr3:52864694 ITIH4 0.35 6.02 0.32 4.62e-9 Bipolar disorder; CRC trans rs2303319 0.504 rs62189053 chr2:162624324 G/A cg22677401 chr17:46026860 NA -0.67 -6.09 -0.32 3.14e-9 Cognitive function; CRC cis rs8014671 0.597 rs1044527 chr14:70833819 C/G cg25576086 chr14:70833871 SYNJ2BP -0.41 -7.45 -0.38 8.28e-13 Prostate cancer; CRC trans rs11098499 0.863 rs6534141 chr4:120485223 A/T cg25214090 chr10:38739885 LOC399744 0.67 10.46 0.5 2.59e-22 Corneal astigmatism; CRC cis rs6951245 1.000 rs80212261 chr7:1114012 C/T cg20603222 chr7:1096387 C7orf50;GPR146 -0.72 -8.6 -0.43 3.27e-16 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs8177253 0.763 rs12769 chr3:133474328 G/A cg16262614 chr3:133464971 TF 0.36 6.15 0.32 2.22e-9 Iron status biomarkers; CRC cis rs11098499 0.779 rs10857066 chr4:120286596 C/T cg24375607 chr4:120327624 NA 0.47 7.38 0.38 1.27e-12 Corneal astigmatism; CRC cis rs2882667 0.690 rs288017 chr5:138193515 A/T cg09476006 chr5:138032270 NA -0.54 -8.92 -0.44 3.21e-17 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs172166 0.516 rs1225710 chr6:28100640 C/T cg06470822 chr6:28175283 NA -0.69 -10.51 -0.5 1.88e-22 Cardiac Troponin-T levels; CRC cis rs12477438 0.501 rs12992218 chr2:99753834 G/A cg14399236 chr2:99771627 LIPT1;TSGA10 0.82 14.44 0.62 5.96e-37 Chronic sinus infection; CRC cis rs6696846 0.740 rs11240369 chr1:205115099 G/A cg00857998 chr1:205179979 DSTYK 0.46 6.27 0.33 1.14e-9 Red blood cell count; CRC cis rs9457247 0.534 rs933243 chr6:167403873 A/C cg23791538 chr6:167370224 RNASET2 -0.49 -8.04 -0.41 1.61e-14 Crohn's disease; CRC cis rs4665809 1.000 rs2053367 chr2:26293413 T/C cg22920501 chr2:26401640 FAM59B -0.52 -7.08 -0.36 8.75e-12 Gut microbiome composition (summer); CRC cis rs9303401 0.659 rs35082010 chr17:56936867 A/G cg02118635 chr17:56770003 RAD51C;TEX14 0.78 9.94 0.48 1.59e-20 Cognitive test performance; CRC trans rs561341 0.883 rs4795661 chr17:30201774 T/A cg20587970 chr11:113659929 NA 0.9 11.01 0.52 3.3e-24 Hip circumference adjusted for BMI; CRC cis rs7107174 1.000 rs4945274 chr11:78109260 G/A cg12700464 chr11:78128424 GAB2 -0.49 -5.82 -0.31 1.38e-8 Testicular germ cell tumor; CRC cis rs875971 0.862 rs11769079 chr7:65842128 G/A cg12463550 chr7:65579703 CRCP 0.5 6.98 0.36 1.65e-11 Aortic root size; CRC cis rs10504073 0.584 rs62507177 chr8:49937306 C/A cg00325661 chr8:49890786 NA 0.59 10.63 0.51 7.18e-23 Blood metabolite ratios; CRC cis rs6541297 0.793 rs6692319 chr1:230284375 C/T cg20703242 chr1:230279135 GALNT2 0.53 7.94 0.4 3.33e-14 Coronary artery disease; CRC cis rs9910055 0.531 rs6503490 chr17:42246656 A/G cg10896456 chr17:42255109 ASB16;C17orf65 0.45 7.79 0.39 9.11e-14 Total body bone mineral density; CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg11196904 chr1:10491304 APITD1 0.36 5.97 0.31 6.14e-9 Obesity-related traits; CRC cis rs7647973 0.922 rs6809851 chr3:49309787 C/A cg20833759 chr3:49053208 WDR6;DALRD3 0.52 7.74 0.39 1.26e-13 Menarche (age at onset); CRC cis rs11212617 0.967 rs227058 chr11:108265213 T/C cg14761454 chr11:108092087 ATM;NPAT 0.44 6.68 0.35 1.03e-10 Response to metformin in type 2 diabetes (glycemic); CRC cis rs4819052 0.851 rs2838831 chr21:46664775 C/T cg11663144 chr21:46675770 NA -0.81 -13.87 -0.61 9.2e-35 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs7103648 0.695 rs10838726 chr11:47568344 C/G cg20307385 chr11:47447363 PSMC3 0.85 12.58 0.57 7e-30 Diastolic blood pressure;Systolic blood pressure; CRC cis rs245880 0.740 rs245886 chr7:29189336 G/T cg17163760 chr7:29186267 CPVL -0.39 -6.73 -0.35 7.63e-11 Warfarin maintenance dose; CRC cis rs6964587 0.773 rs12536421 chr7:92008220 A/G cg17063962 chr7:91808500 NA 0.69 10.35 0.5 6.36e-22 Breast cancer; CRC cis rs9611565 0.765 rs202663 chr22:41812819 T/C cg03806693 chr22:41940476 POLR3H 0.98 12.27 0.56 9.8e-29 Vitiligo; CRC cis rs11645898 0.748 rs72791112 chr16:72204069 T/A cg14768367 chr16:72042858 DHODH -0.6 -6.62 -0.34 1.5e-10 Blood protein levels; CRC cis rs4713118 0.513 rs156738 chr6:28014025 G/C cg12172441 chr6:28176163 NA 0.5 6.73 0.35 7.38e-11 Parkinson's disease; CRC cis rs3820068 0.603 rs927207 chr1:15990552 A/G cg27534772 chr1:16042836 PLEKHM2 0.54 10.0 0.48 9.85e-21 Systolic blood pressure; CRC cis rs6580110 0.793 rs6868098 chr5:154080958 G/A cg11923914 chr5:154071666 NA -0.48 -7.23 -0.37 3.38e-12 Facial morphology (factor 9, facial height related to vertical position of nasion); CRC cis rs6504950 0.800 rs7209926 chr17:53006324 C/T cg26251398 chr17:52985966 TOM1L1 -0.38 -5.81 -0.31 1.45e-8 Breast cancer; CRC cis rs9291683 0.546 rs6829727 chr4:10051672 A/C cg11266682 chr4:10021025 SLC2A9 0.49 9.43 0.46 7.5e-19 Bone mineral density; CRC cis rs2230307 0.536 rs575971 chr1:100546591 T/C cg24955406 chr1:100503596 HIAT1 0.53 6.11 0.32 2.83e-9 Carotid intima media thickness; CRC cis rs7208859 0.623 rs7503542 chr17:29073830 A/C cg13385521 chr17:29058706 SUZ12P 0.72 8.17 0.41 6.77e-15 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs10463316 0.894 rs1876619 chr5:150744773 G/C cg03212797 chr5:150827313 SLC36A1 -0.51 -7.87 -0.4 5.2e-14 Metabolite levels (Pyroglutamine); CRC cis rs877282 0.898 rs11253347 chr10:765769 A/G cg17470449 chr10:769945 NA 0.64 8.08 0.41 1.28e-14 Uric acid levels; CRC cis rs10752881 0.905 rs12132262 chr1:182989949 T/A ch.1.3577855R chr1:183094577 LAMC1 0.86 15.17 0.64 8.93e-40 Colorectal cancer; CRC cis rs780096 0.526 rs780107 chr2:27684734 A/G cg27432699 chr2:27873401 GPN1 -0.52 -7.96 -0.4 2.91e-14 Total body bone mineral density; CRC cis rs2836974 0.568 rs428602 chr21:40547004 A/G cg11644478 chr21:40555479 PSMG1 0.69 11.05 0.52 2.38e-24 Cognitive function; CRC cis rs4563143 0.675 rs73029050 chr19:29276554 G/T cg14983838 chr19:29218262 NA 0.49 7.07 0.36 9.48e-12 Methadone dose in opioid dependence; CRC cis rs757110 0.648 rs12146443 chr11:17384498 T/C cg15432903 chr11:17409602 KCNJ11 0.77 11.66 0.54 1.6e-26 Type 2 diabetes; CRC cis rs4242434 0.672 rs7830206 chr8:22485375 C/T cg03733263 chr8:22462867 KIAA1967 0.86 14.77 0.63 3.26e-38 Exploratory eye movement dysfunction in schizophrenia (cognitive search score); CRC cis rs1005277 0.579 rs2023351 chr10:38378814 A/G cg25427524 chr10:38739819 LOC399744 -0.76 -13.55 -0.6 1.57e-33 Extrinsic epigenetic age acceleration; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg06685340 chr10:82213598 TSPAN14 0.41 5.99 0.31 5.38e-9 Intelligence (multi-trait analysis); CRC cis rs172166 0.515 rs2622320 chr6:28115336 T/A cg02683197 chr6:28174875 NA 0.47 6.65 0.34 1.24e-10 Cardiac Troponin-T levels; CRC trans rs10982213 0.830 rs2274163 chr9:117188714 C/T cg19320564 chr1:40157253 HPCAL4 0.36 6.01 0.31 4.85e-9 Interleukin-6 levels; CRC cis rs853679 0.517 rs9348794 chr6:28117757 T/A cg18032046 chr6:28092343 ZSCAN16 -0.51 -5.93 -0.31 7.47e-9 Depression; CRC trans rs916888 0.647 rs199524 chr17:44848438 G/T cg07870213 chr5:140052090 DND1 -0.62 -8.13 -0.41 8.96e-15 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs765787 0.530 rs28733848 chr15:45516047 C/T cg24006582 chr15:45444508 DUOX1 -0.57 -8.75 -0.43 1.15e-16 Uric acid levels; CRC trans rs7618501 1.000 rs11709680 chr3:49745188 C/T cg21659725 chr3:3221576 CRBN -0.9 -17.6 -0.7 2.53e-49 Intelligence (multi-trait analysis); CRC cis rs8141529 0.509 rs12628211 chr22:29239250 T/C cg02153584 chr22:29168773 CCDC117 0.5 6.93 0.36 2.21e-11 Lymphocyte counts; CRC trans rs62103177 0.608 rs4442895 chr18:77826399 C/G cg05926928 chr17:57297772 GDPD1 -0.53 -6.4 -0.33 5.31e-10 Opioid sensitivity; CRC cis rs8060686 0.565 rs11555011 chr16:68088485 A/G cg08314208 chr16:67682810 RLTPR -0.63 -6.75 -0.35 6.58e-11 HDL cholesterol;Metabolic syndrome; CRC cis rs9549367 0.713 rs3024747 chr13:113821787 C/G cg00898013 chr13:113819073 PROZ -0.56 -8.12 -0.41 9.6e-15 Platelet distribution width; CRC cis rs765787 0.530 rs28526629 chr15:45540462 C/T cg24006582 chr15:45444508 DUOX1 -0.53 -8.29 -0.42 3.01e-15 Uric acid levels; CRC cis rs7493 0.853 rs17166879 chr7:95053415 A/G cg20119798 chr7:94954144 PON1 -0.52 -6.48 -0.34 3.39e-10 Yu-Zhi constitution type in type 2 diabetes; CRC trans rs11343 0.675 rs7359333 chr16:19262344 A/T cg16236679 chr11:96123321 JRKL;CCDC82 -0.48 -6.07 -0.32 3.46e-9 Parkinson's disease; CRC cis rs2386661 0.523 rs7896088 chr10:5652286 C/T cg26603656 chr10:5671107 NA 0.39 7.25 0.37 2.94e-12 Breast cancer; CRC trans rs7618501 0.932 rs4855850 chr3:49761571 G/A cg21582582 chr3:182698605 DCUN1D1 -0.56 -8.26 -0.41 3.59e-15 Intelligence (multi-trait analysis); CRC cis rs853679 0.517 rs9348797 chr6:28137533 G/C cg02631126 chr6:28058918 ZSCAN12L1 0.29 5.91 0.31 8.38e-9 Depression; CRC cis rs10905065 0.965 rs12571639 chr10:5748052 G/A cg11519256 chr10:5708881 ASB13 0.44 6.31 0.33 8.92e-10 Menopause (age at onset); CRC cis rs2762353 0.902 rs3799344 chr6:25786993 C/T cg03264133 chr6:25882463 NA 0.45 6.54 0.34 2.38e-10 Blood metabolite levels; CRC trans rs9467711 0.659 rs72845428 chr6:26550144 C/T cg06606381 chr12:133084897 FBRSL1 -1.07 -7.41 -0.38 1.09e-12 Autism spectrum disorder or schizophrenia; CRC cis rs12325245 0.536 rs12925676 chr16:58625326 C/T cg02549819 chr16:58548995 SETD6 1.2 7.97 0.4 2.72e-14 Schizophrenia; CRC cis rs7927771 0.524 rs11039419 chr11:47851354 C/T cg20307385 chr11:47447363 PSMC3 0.45 6.62 0.34 1.48e-10 Subjective well-being; CRC cis rs796364 1.000 rs35220450 chr2:200780737 T/C cg12253985 chr2:200820533 C2orf60;C2orf47 -0.65 -6.32 -0.33 8.69e-10 Schizophrenia; CRC cis rs77633900 0.772 rs2957560 chr15:76700310 A/T cg21673338 chr15:77095150 SCAPER -0.66 -5.61 -0.3 4.23e-8 Non-glioblastoma glioma;Glioma; CRC cis rs7927771 1.000 rs11039426 chr11:47863119 G/A cg20307385 chr11:47447363 PSMC3 -0.49 -6.58 -0.34 1.89e-10 Subjective well-being; CRC cis rs2976388 0.566 rs4736373 chr8:143792357 G/C cg24634471 chr8:143751801 JRK -0.47 -6.55 -0.34 2.26e-10 Urinary tract infection frequency; CRC trans rs2303319 0.504 rs58622044 chr2:162596287 A/G cg27342122 chr8:133787442 PHF20L1 -0.71 -6.02 -0.31 4.6e-9 Cognitive function; CRC cis rs62244186 0.659 rs7649834 chr3:44503732 C/T cg11003573 chr3:44754125 ZNF502 -0.33 -5.68 -0.3 2.98e-8 Depressive symptoms; CRC cis rs7178572 0.524 rs12914128 chr15:77493875 T/C cg22256960 chr15:77711686 NA -0.67 -9.56 -0.47 2.93e-19 Type 2 diabetes; CRC cis rs863345 0.604 rs11265009 chr1:158498772 C/T cg12129480 chr1:158549410 OR10X1 -0.29 -6.08 -0.32 3.42e-9 Pneumococcal bacteremia; CRC cis rs875971 0.895 rs10447522 chr7:65796074 A/G cg12463550 chr7:65579703 CRCP -0.49 -6.58 -0.34 1.85e-10 Aortic root size; CRC cis rs9640161 0.742 rs2108851 chr7:150019634 T/C cg12556325 chr7:150026731 C7orf29;LRRC61 -0.44 -6.42 -0.33 4.63e-10 Blood protein levels;Circulating chemerin levels; CRC cis rs6701037 1.000 rs11580331 chr1:175123288 T/C cg00321850 chr1:175162397 KIAA0040 -0.37 -5.93 -0.31 7.86e-9 Alcohol dependence; CRC cis rs11785400 0.793 rs4430071 chr8:143737680 T/C cg24634471 chr8:143751801 JRK 0.48 6.52 0.34 2.63e-10 Schizophrenia; CRC cis rs6502050 0.835 rs7406220 chr17:80077850 T/C cg25804541 chr17:80189381 SLC16A3 0.31 6.01 0.31 4.93e-9 Life satisfaction; CRC cis rs6674176 0.542 rs3011225 chr1:44319373 G/A cg12908607 chr1:44402522 ARTN -0.47 -8.18 -0.41 6.32e-15 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Cognitive ability; CRC cis rs7552404 1.000 rs211718 chr1:76106675 C/T cg10523679 chr1:76189770 ACADM 0.77 10.6 0.5 8.75e-23 Blood metabolite levels;Acylcarnitine levels; CRC cis rs11212617 1.000 rs599558 chr11:108177538 C/T cg14761454 chr11:108092087 ATM;NPAT 0.43 6.52 0.34 2.68e-10 Response to metformin in type 2 diabetes (glycemic); CRC cis rs6840360 0.642 rs1443090 chr4:152451819 T/C cg09659197 chr4:152720779 NA 0.33 6.47 0.34 3.61e-10 Intelligence (multi-trait analysis); CRC cis rs911555 0.755 rs11627446 chr14:103946450 G/C cg24130564 chr14:104152367 KLC1 -0.41 -5.67 -0.3 3.11e-8 Intelligence (multi-trait analysis); CRC cis rs172166 0.694 rs2791332 chr6:28108788 C/T cg17949981 chr6:28129498 ZNF389 0.41 5.67 0.3 3.12e-8 Cardiac Troponin-T levels; CRC cis rs1568889 0.838 rs7121937 chr11:28359858 A/G cg06544937 chr11:28130018 METT5D1;KIF18A 0.91 15.36 0.65 1.62e-40 Bipolar disorder; CRC cis rs9291683 0.655 rs35750364 chr4:10049049 T/C cg11266682 chr4:10021025 SLC2A9 0.53 11.17 0.52 9e-25 Bone mineral density; CRC cis rs9463078 0.585 rs7754378 chr6:44863106 A/G cg25276700 chr6:44698697 NA 0.25 6.07 0.32 3.45e-9 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; CRC cis rs67478160 0.643 rs11628332 chr14:104241141 C/T cg01849466 chr14:104193079 ZFYVE21 -0.51 -9.04 -0.45 1.34e-17 Schizophrenia; CRC cis rs9522267 0.535 rs9522291 chr13:112233761 T/C cg26182253 chr13:112236782 NA 0.31 6.29 0.33 9.96e-10 Hepatitis; CRC cis rs9322817 0.902 rs9322812 chr6:105194651 A/G cg02098413 chr6:105308735 HACE1 -0.36 -6.58 -0.34 1.9e-10 Thyroid stimulating hormone; CRC cis rs3771570 0.901 rs73006381 chr2:242406654 G/C cg21155796 chr2:242212141 HDLBP 0.63 6.8 0.35 4.92e-11 Prostate cancer; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg05860723 chr12:81102486 MYF6 0.18 6.09 0.32 3.13e-9 Liver disease severity in Alagille syndrome; CRC cis rs11155671 0.530 rs7758033 chr6:150208135 T/C cg07701084 chr6:150067640 NUP43 0.46 6.66 0.34 1.18e-10 Testicular germ cell tumor; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg03856714 chr2:96658020 NA 0.43 6.25 0.33 1.28e-9 Intelligence (multi-trait analysis); CRC cis rs7647973 0.961 rs4955443 chr3:49286618 T/G cg07690219 chr3:49449608 TCTA;RHOA -0.48 -5.66 -0.3 3.34e-8 Menarche (age at onset); CRC cis rs2204008 0.782 rs11514339 chr12:38236670 G/A cg26384229 chr12:38710491 ALG10B 0.7 9.31 0.46 1.92e-18 Bladder cancer; CRC trans rs10504229 1.000 rs66672857 chr8:58179817 G/C cg04077850 chr5:125800366 GRAMD3 0.37 6.27 0.33 1.15e-9 Developmental language disorder (linguistic errors); CRC cis rs317689 0.876 rs547332 chr12:69743639 C/G cg20891283 chr12:69753455 YEATS4 0.67 9.31 0.46 1.93e-18 Response to diuretic therapy; CRC cis rs12024301 0.557 rs7530186 chr1:183610283 T/A cg11505048 chr1:183622726 RGL1;APOBEC4 0.81 7.0 0.36 1.42e-11 Peripheral arterial disease (traffic-related air pollution interaction); CRC trans rs9395066 0.545 rs3799976 chr6:44835622 T/G cg04786201 chr1:17185605 NA 0.28 6.04 0.32 4.21e-9 Height; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg26354228 chr1:29213635 EPB41 0.4 6.15 0.32 2.24e-9 Intelligence (multi-trait analysis); CRC cis rs7119 0.717 rs7176307 chr15:77816684 G/C cg27398640 chr15:77910606 LINGO1 -0.43 -7.47 -0.38 7.13e-13 Type 2 diabetes; CRC cis rs250677 0.798 rs11168080 chr5:148409821 C/T cg18129178 chr5:148520854 ABLIM3 -0.4 -5.83 -0.31 1.36e-8 Breast cancer; CRC trans rs2890652 0.646 rs72853432 chr2:142973655 T/G cg00809969 chr7:27181067 HOXA5 -0.68 -6.11 -0.32 2.76e-9 Body mass index; CRC trans rs11098499 0.954 rs17006190 chr4:120418838 C/G cg25214090 chr10:38739885 LOC399744 0.65 10.04 0.48 7.12e-21 Corneal astigmatism; CRC trans rs7618501 1.000 rs7618501 chr3:49772647 A/G cg21659725 chr3:3221576 CRBN -0.9 -17.3 -0.69 3.92e-48 Intelligence (multi-trait analysis); CRC cis rs2836974 0.644 rs719230 chr21:40676307 C/T cg11644478 chr21:40555479 PSMG1 -0.69 -11.13 -0.52 1.24e-24 Cognitive function; CRC cis rs57561814 1.000 rs6949149 chr7:22749157 G/T cg26061582 chr7:22766209 IL6 0.74 6.27 0.33 1.13e-9 Tonsillectomy; CRC cis rs10504229 0.683 rs16921817 chr8:58107563 A/T cg05313129 chr8:58192883 C8orf71 -0.43 -5.87 -0.31 1.09e-8 Developmental language disorder (linguistic errors); CRC cis rs758324 0.947 rs60847707 chr5:131252554 C/T cg06307176 chr5:131281290 NA -0.43 -6.36 -0.33 6.64e-10 Alzheimer's disease in APOE e4- carriers; CRC cis rs9322193 0.884 rs9383864 chr6:150173105 T/C cg07701084 chr6:150067640 NUP43 0.49 6.8 0.35 4.98e-11 Lung cancer; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg01076405 chr8:99057832 RPL30 0.36 6.09 0.32 3.09e-9 Liver disease severity in Alagille syndrome; CRC cis rs9549260 0.755 rs7335520 chr13:41196407 C/T cg21288729 chr13:41239152 FOXO1 0.43 6.7 0.35 9.06e-11 Red blood cell count; CRC cis rs2749592 0.505 rs7915670 chr10:37870212 T/C cg00409905 chr10:38381863 ZNF37A 0.59 9.38 0.46 1.08e-18 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs9393692 1.000 rs3999544 chr6:26285867 C/T cg00631329 chr6:26305371 NA -0.72 -13.49 -0.6 2.56e-33 Educational attainment; CRC cis rs634534 0.622 rs1192168 chr11:65730945 T/G cg17985854 chr11:65770987 BANF1;EIF1AD 0.42 6.98 0.36 1.6e-11 Sum eosinophil basophil counts;Eosinophil counts; CRC cis rs4964805 0.632 rs11111782 chr12:104188476 A/G cg02344784 chr12:104178138 NT5DC3 -0.77 -14.48 -0.62 4.34e-37 Attention deficit hyperactivity disorder; CRC cis rs763121 0.752 rs6001190 chr22:39073811 T/C cg06022373 chr22:39101656 GTPBP1 0.79 12.58 0.57 6.77e-30 Menopause (age at onset); CRC cis rs6942756 0.712 rs6467241 chr7:128997838 A/G cg02491457 chr7:128862824 NA -0.62 -8.47 -0.42 8.32e-16 White matter hyperintensity burden; CRC cis rs6088580 0.634 rs1205338 chr20:32925625 C/G cg08999081 chr20:33150536 PIGU -0.65 -12.21 -0.56 1.5e-28 Glomerular filtration rate (creatinine); CRC cis rs394563 0.775 rs420430 chr6:149785539 T/G cg07828024 chr6:149772892 ZC3H12D -0.53 -9.34 -0.46 1.44e-18 Dupuytren's disease; CRC trans rs3733585 0.699 rs6844787 chr4:9959233 A/G cg26043149 chr18:55253948 FECH -0.5 -7.62 -0.39 2.81e-13 Cleft plate (environmental tobacco smoke interaction); CRC cis rs9858542 1.000 rs4283605 chr3:49678651 A/G cg00383909 chr3:49044727 WDR6 0.48 5.96 0.31 6.48e-9 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs9611565 0.918 rs12484074 chr22:41752747 G/A cg06634786 chr22:41940651 POLR3H -0.63 -7.37 -0.38 1.43e-12 Vitiligo; CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg04677061 chr11:32112634 RCN1 0.39 6.06 0.32 3.67e-9 Obesity-related traits; CRC cis rs9847710 0.967 rs2564938 chr3:53026384 C/T cg04503182 chr3:53078218 SFMBT1 0.43 6.36 0.33 6.77e-10 Ulcerative colitis; CRC cis rs13108904 0.557 rs1680033 chr4:1243404 C/T cg21620606 chr4:1342894 KIAA1530 -0.44 -7.07 -0.36 9.14e-12 Obesity-related traits; CRC cis rs9322193 0.924 rs9498382 chr6:149932118 A/G cg13206674 chr6:150067644 NUP43 0.64 9.69 0.47 1.04e-19 Lung cancer; CRC cis rs863345 0.604 rs1873509 chr1:158461563 A/G cg12129480 chr1:158549410 OR10X1 0.28 5.76 0.3 1.94e-8 Pneumococcal bacteremia; CRC cis rs9648716 0.554 rs1092351 chr7:140657027 A/G cg10747023 chr7:140774559 NA 0.43 5.84 0.31 1.24e-8 Type 2 diabetes; CRC cis rs2839186 0.934 rs2839197 chr21:47708133 A/G cg09417038 chr21:47716443 C21orf57 -0.42 -6.93 -0.36 2.21e-11 Testicular germ cell tumor; CRC cis rs853679 0.517 rs4713152 chr6:28137454 G/A cg06470822 chr6:28175283 NA 1.03 13.59 0.6 1.04e-33 Depression; CRC cis rs427394 0.664 rs274722 chr5:6718668 C/T cg10857441 chr5:6722123 POLS -0.4 -6.19 -0.32 1.75e-9 Menopause (age at onset); CRC cis rs6565681 1.000 rs4889848 chr17:78354661 C/T cg15383979 chr17:78362278 RNF213;LOC100294362 -0.54 -6.12 -0.32 2.71e-9 Moyamoya disease; CRC cis rs6495367 1.000 rs1961579 chr15:79380516 G/A cg17916960 chr15:79447300 NA 0.42 6.82 0.35 4.25e-11 Spherical equivalent (joint analysis main effects and education interaction); CRC trans rs116095464 0.558 rs7708182 chr5:234788 C/G cg00938859 chr5:1591904 SDHAP3 0.74 7.92 0.4 3.68e-14 Breast cancer; CRC cis rs4604732 0.642 rs10925048 chr1:247640736 T/C cg02104434 chr1:247694406 LOC148824;OR2C3 0.41 6.78 0.35 5.64e-11 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CRC cis rs9902453 0.904 rs4598962 chr17:28293948 C/G cg26525008 chr17:28256777 EFCAB5;SSH2 0.66 10.85 0.51 1.15e-23 Coffee consumption (cups per day); CRC cis rs5769765 0.955 rs9616204 chr22:50303530 T/C cg04121214 chr22:50244548 NA 0.39 5.78 0.3 1.75e-8 Schizophrenia; CRC cis rs1707322 0.656 rs9429172 chr1:46092476 C/G cg03146154 chr1:46216737 IPP -0.66 -9.27 -0.46 2.45e-18 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs2739330 0.731 rs2000468 chr22:24241611 G/T cg04234412 chr22:24373322 LOC391322 -0.75 -12.45 -0.57 2.02e-29 Liver enzyme levels (gamma-glutamyl transferase); CRC trans rs17780086 0.527 rs72827711 chr17:30537920 T/A cg27661571 chr11:113659931 NA -0.93 -9.31 -0.46 1.85e-18 Height; CRC cis rs651907 0.535 rs36060163 chr3:101360963 C/T cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.64 8.59 0.43 3.65e-16 Colorectal cancer; CRC cis rs10504229 0.775 rs17805110 chr8:58161439 C/G cg05313129 chr8:58192883 C8orf71 0.47 6.15 0.32 2.29e-9 Developmental language disorder (linguistic errors); CRC cis rs9467711 0.606 rs9379859 chr6:26369549 C/T cg14345882 chr6:26364793 BTN3A2 0.65 5.74 0.3 2.17e-8 Autism spectrum disorder or schizophrenia; CRC cis rs9914988 0.943 rs7211502 chr17:27163295 C/A cg20469991 chr17:27169893 C17orf63 -0.58 -6.85 -0.35 3.68e-11 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC trans rs2243480 0.803 rs34804747 chr7:65412942 G/C cg10756647 chr7:56101905 PSPH 0.72 7.98 0.4 2.39e-14 Diabetic kidney disease; CRC cis rs972578 1.000 rs5759086 chr22:43404929 C/G cg01576275 chr22:43409880 NA -0.51 -8.38 -0.42 1.53e-15 Mean platelet volume; CRC cis rs754466 0.580 rs10430529 chr10:79582623 C/A cg26805224 chr10:79626177 DLG5 -0.51 -7.45 -0.38 8.07e-13 Liver enzyme levels (gamma-glutamyl transferase); CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg18938469 chr14:23564120 C14orf119;ACIN1 0.5 6.96 0.36 1.91e-11 Anxiety disorder; CRC trans rs1005277 0.579 rs2474567 chr10:38382492 C/T cg11292332 chr7:45801988 SEPT13 -0.35 -6.26 -0.33 1.19e-9 Extrinsic epigenetic age acceleration; CRC cis rs2204008 0.777 rs8189597 chr12:38307739 G/C cg26384229 chr12:38710491 ALG10B -0.66 -8.82 -0.44 7.04e-17 Bladder cancer; CRC cis rs713477 0.967 rs1572613 chr14:55909897 C/T cg13175173 chr14:55914753 NA -0.52 -9.85 -0.48 3.19e-20 Pediatric bone mineral content (femoral neck); CRC cis rs9303401 0.659 rs34351230 chr17:56782555 C/A cg10487724 chr17:56770010 TEX14;RAD51C 0.79 10.0 0.48 1.01e-20 Cognitive test performance; CRC trans rs6951245 0.706 rs28685743 chr7:1197736 C/T cg13565492 chr6:43139072 SRF -0.67 -7.23 -0.37 3.36e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs10905065 0.610 rs55913768 chr10:5749449 G/A cg11519256 chr10:5708881 ASB13 -0.44 -6.05 -0.32 4.02e-9 Menopause (age at onset); CRC cis rs2380220 0.541 rs9285413 chr6:96023439 G/A cg15832292 chr6:96025679 MANEA 0.61 6.71 0.35 8.38e-11 Behavioural disinhibition (generation interaction); CRC trans rs3733585 0.699 rs10017674 chr4:9967053 T/C cg26043149 chr18:55253948 FECH -0.49 -7.51 -0.38 5.78e-13 Cleft plate (environmental tobacco smoke interaction); CRC cis rs7772486 0.875 rs2777483 chr6:146329235 A/G cg13319975 chr6:146136371 FBXO30 -0.38 -5.72 -0.3 2.38e-8 Lobe attachment (rater-scored or self-reported); CRC cis rs6752107 0.503 rs2304776 chr2:234227693 C/T cg07618928 chr2:234183455 ATG16L1;SCARNA5 0.53 7.93 0.4 3.5e-14 Crohn's disease;Inflammatory bowel disease; CRC trans rs11098499 0.866 rs10518329 chr4:120401835 A/G cg25214090 chr10:38739885 LOC399744 0.61 9.73 0.47 7.79e-20 Corneal astigmatism; CRC cis rs875971 0.862 rs9791713 chr7:66105198 C/A cg12463550 chr7:65579703 CRCP -0.45 -6.1 -0.32 3e-9 Aortic root size; CRC cis rs6968419 0.641 rs17138519 chr7:115906178 T/C cg02561103 chr7:115862891 TES -0.42 -6.32 -0.33 8.33e-10 Intraocular pressure; CRC cis rs9303401 0.538 rs3785493 chr17:56472119 G/T cg02118635 chr17:56770003 RAD51C;TEX14 -0.67 -8.18 -0.41 6.4e-15 Cognitive test performance; CRC cis rs13108904 0.967 rs4428235 chr4:1278891 C/T cg02018176 chr4:1364513 KIAA1530 0.48 7.88 0.4 4.67e-14 Obesity-related traits; CRC cis rs17376456 0.877 rs2085960 chr5:93399934 A/G cg25358565 chr5:93447407 FAM172A 1.02 10.4 0.5 4.25e-22 Diabetic retinopathy; CRC cis rs2777491 1.000 rs316610 chr15:41752852 C/T cg18705301 chr15:41695430 NDUFAF1 -0.75 -12.93 -0.58 3.38e-31 Ulcerative colitis; CRC cis rs812925 0.892 rs4672440 chr2:61616653 T/G cg10580144 chr2:61372316 C2orf74 -0.31 -6.39 -0.33 5.68e-10 Immature fraction of reticulocytes; CRC cis rs12620999 0.838 rs7589198 chr2:237967615 C/T cg23555395 chr2:238036564 NA 0.48 7.59 0.39 3.42e-13 Systemic lupus erythematosus; CRC cis rs11190604 1.000 rs3750633 chr10:102308214 C/T cg16342193 chr10:102329863 NA -0.39 -6.32 -0.33 8.34e-10 Palmitoleic acid (16:1n-7) levels; CRC cis rs1348850 0.645 rs13431091 chr2:178434615 A/G cg27490568 chr2:178487706 NA 0.5 6.23 0.32 1.41e-9 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC trans rs2303319 0.504 rs72870226 chr2:162420429 T/C cg18122310 chr12:50236657 BCDIN3D -0.72 -6.04 -0.32 4.15e-9 Cognitive function; CRC cis rs2982552 0.873 rs2152751 chr6:152069999 A/G cg22157087 chr6:152012887 ESR1 0.38 5.87 0.31 1.05e-8 Bone properties (heel); CRC cis rs9814567 1.000 rs7611828 chr3:134250325 C/T cg06541857 chr3:134203789 ANAPC13;CEP63 -0.4 -6.12 -0.32 2.65e-9 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs929354 0.772 rs2366214 chr7:156992461 A/G cg17757837 chr7:157058334 UBE3C 0.74 12.57 0.57 7.46e-30 Body mass index; CRC cis rs9733 0.519 rs7511673 chr1:150707636 A/T cg18016565 chr1:150552671 MCL1 0.46 6.53 0.34 2.53e-10 Tonsillectomy; CRC cis rs367615 0.660 rs10477972 chr5:108831951 C/A cg17395555 chr5:108820864 NA 0.45 9.15 0.45 5.95e-18 Colorectal cancer (SNP x SNP interaction); CRC cis rs78456975 1.000 rs13431491 chr2:1553808 T/A cg12573674 chr2:1569213 NA -0.77 -8.03 -0.4 1.78e-14 Placebo response in major depressive disorder (% change in symptom score); CRC trans rs1642645 0.831 rs7535305 chr1:42489602 C/A cg16926213 chr1:1841314 NA -0.43 -6.08 -0.32 3.37e-9 Left ventricular obstructive tract defect (maternal effect); CRC cis rs853679 0.550 rs6901017 chr6:28152583 T/C cg19592336 chr6:28129416 ZNF389 0.48 5.86 0.31 1.14e-8 Depression; CRC trans rs7615952 0.546 rs2922197 chr3:125322032 G/A cg07211511 chr3:129823064 LOC729375 -0.61 -6.97 -0.36 1.73e-11 Blood pressure (smoking interaction); CRC cis rs7849270 1.000 rs7849160 chr9:131874552 A/T cg13538475 chr9:131942899 NA -0.3 -5.98 -0.31 5.76e-9 Blood metabolite ratios; CRC cis rs11112613 0.713 rs58066965 chr12:105952505 C/G cg03607813 chr12:105948248 NA 0.78 10.91 0.52 7.6e-24 Corrected insulin response;Corrected insulin response adjusted for insulin sensitivity index; CRC cis rs4733770 0.581 rs12550366 chr8:131136047 A/T cg21674704 chr8:131455249 NA -0.37 -5.99 -0.31 5.46e-9 Schizophrenia; CRC cis rs6087990 0.735 rs6058883 chr20:31365719 C/T cg13636640 chr20:31349939 DNMT3B -0.8 -15.38 -0.65 1.29e-40 Ulcerative colitis; CRC cis rs9322193 0.962 rs10872653 chr6:150100043 A/C cg05861140 chr6:150128134 PCMT1 -0.43 -7.05 -0.36 1.03e-11 Lung cancer; CRC trans rs8035957 1.000 rs4924273 chr15:38846738 C/G ch.8.34907260F chr8:34787718 NA -0.53 -6.29 -0.33 9.93e-10 Type 1 diabetes; CRC cis rs6540559 1.000 rs17015259 chr1:209982923 G/A cg23283495 chr1:209979779 IRF6 0.42 6.93 0.36 2.22e-11 Cleft lip with or without cleft palate; CRC cis rs11122272 0.735 rs11122280 chr1:231519816 T/C cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.52 -7.74 -0.39 1.25e-13 Hemoglobin concentration; CRC cis rs2806561 0.704 rs588387 chr1:23523689 A/G cg12483005 chr1:23474871 LUZP1 0.49 7.01 0.36 1.33e-11 Height; CRC cis rs9322193 0.923 rs4421206 chr6:150004027 A/C cg13206674 chr6:150067644 NUP43 0.65 9.76 0.47 6.03e-20 Lung cancer; CRC cis rs13191362 1.000 rs55847707 chr6:163003414 G/A cg23758597 chr6:163146217 PARK2 -0.55 -6.12 -0.32 2.61e-9 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs910316 0.763 rs4556 chr14:75476071 G/C cg11812906 chr14:75593930 NEK9 0.59 9.02 0.45 1.59e-17 Height; CRC cis rs311392 1.000 rs2666871 chr8:55089184 C/T cg20636351 chr8:55087400 NA -0.34 -6.06 -0.32 3.65e-9 Pelvic organ prolapse (moderate/severe); CRC cis rs6502050 0.814 rs62079997 chr17:80076888 C/T cg19223190 chr17:80058835 NA -0.41 -6.56 -0.34 2.07e-10 Life satisfaction; CRC cis rs1799949 1.000 rs16941 chr17:41244435 T/C cg23758822 chr17:41437982 NA 0.81 13.52 0.6 1.92e-33 Menopause (age at onset); CRC cis rs7493 1.000 rs2158806 chr7:95051998 A/C cg20119798 chr7:94954144 PON1 -0.51 -6.46 -0.34 3.7e-10 Yu-Zhi constitution type in type 2 diabetes; CRC trans rs9409565 0.762 rs55877910 chr9:97234213 G/C cg05679027 chr9:99775184 HIATL2 -0.4 -6.04 -0.32 4.2e-9 Colorectal cancer (alcohol consumption interaction); CRC cis rs9287719 0.967 rs6432119 chr2:10753687 A/T cg00105475 chr2:10696890 NA 0.45 7.17 0.37 4.85e-12 Prostate cancer; CRC cis rs1799949 0.827 rs74252763 chr17:41402020 C/T cg01879757 chr17:41196368 BRCA1 -0.44 -6.53 -0.34 2.47e-10 Menopause (age at onset); CRC cis rs4332037 0.539 rs11762636 chr7:2061111 C/A cg13880726 chr7:1868755 MAD1L1 -0.46 -5.68 -0.3 2.95e-8 Bipolar disorder; CRC cis rs13256369 1.000 rs12550762 chr8:8576535 T/A cg17143192 chr8:8559678 CLDN23 0.51 6.89 0.35 2.9100000000000002e-11 Obesity-related traits; CRC cis rs1799949 0.965 rs11651623 chr17:41329847 G/A cg23758822 chr17:41437982 NA 0.81 13.61 0.6 9.13e-34 Menopause (age at onset); CRC cis rs12612619 0.704 rs3769139 chr2:27315714 C/T cg00617064 chr2:27272375 NA -0.37 -6.01 -0.31 4.9e-9 Venous thromboembolism adjusted for sickle cell variant rs77121243-T; CRC cis rs8060686 0.920 rs73593810 chr16:67866783 C/T cg07125278 chr16:67683757 RLTPR -0.62 -7.05 -0.36 1.08e-11 HDL cholesterol;Metabolic syndrome; CRC cis rs6681460 1.000 rs6697088 chr1:67044724 C/G cg02459107 chr1:67143332 SGIP1 -0.45 -7.43 -0.38 9.17e-13 Presence of antiphospholipid antibodies; CRC cis rs7959452 0.535 rs7133487 chr12:69774377 G/A cg22834771 chr12:69754056 YEATS4 -0.53 -8.06 -0.41 1.4e-14 Blood protein levels; CRC cis rs7666738 0.962 rs4699605 chr4:99064379 A/G cg05340658 chr4:99064831 C4orf37 0.53 7.42 0.38 1.03e-12 Colonoscopy-negative controls vs population controls; CRC cis rs7666738 0.716 rs2865982 chr4:99031661 T/G cg17366294 chr4:99064904 C4orf37 0.44 7.48 0.38 6.96e-13 Colonoscopy-negative controls vs population controls; CRC cis rs10883723 0.810 rs7094751 chr10:104274818 G/A cg11453585 chr10:104263688 ACTR1A;SUFU 0.91 17.43 0.69 1.17e-48 Allergic disease (asthma, hay fever or eczema); CRC cis rs9346649 0.591 rs1873338 chr6:168492087 T/C cg02770688 chr6:168491649 NA 0.61 8.97 0.44 2.24e-17 Venous thromboembolism adjusted for sickle cell variant rs77121243-T; CRC cis rs17376456 0.825 rs12716454 chr5:93272279 A/C cg09848695 chr5:92956644 FAM172A;MIR2277 0.7 5.99 0.31 5.39e-9 Diabetic retinopathy; CRC cis rs2976388 1.000 rs2920293 chr8:143765414 C/G cg24046110 chr8:143859143 LYNX1 -0.38 -6.6 -0.34 1.65e-10 Urinary tract infection frequency; CRC cis rs8010715 0.816 rs6573572 chr14:24599230 C/A cg23112188 chr14:24563095 PCK2 -0.36 -7.22 -0.37 3.59e-12 IgG glycosylation; CRC cis rs2976388 0.647 rs2164307 chr8:143788831 A/T cg24046110 chr8:143859143 LYNX1 0.47 8.18 0.41 6.22e-15 Urinary tract infection frequency; CRC trans rs7615952 0.551 rs12695470 chr3:125635718 C/A cg07211511 chr3:129823064 LOC729375 -1.2 -18.39 -0.71 1.85e-52 Blood pressure (smoking interaction); CRC cis rs6500395 1.000 rs3919552 chr16:48716328 C/T cg04672837 chr16:48644449 N4BP1 -0.45 -6.63 -0.34 1.38e-10 Response to tocilizumab in rheumatoid arthritis; CRC cis rs3858526 0.917 rs10769386 chr11:5973420 C/T cg13902645 chr11:5959945 NA 0.58 7.59 0.39 3.32e-13 DNA methylation (variation); CRC trans rs10983614 1.000 rs7867776 chr9:120072627 A/G cg18950002 chr17:79673969 MRPL12 0.48 6.64 0.34 1.29e-10 Survival in pancreatic cancer; CRC trans rs7726839 0.540 rs72705097 chr5:655067 G/A cg11887960 chr12:57824829 NA 0.64 7.2 0.37 4.1e-12 Obesity-related traits; CRC cis rs4713118 0.715 rs200480 chr6:27773664 A/G cg15786705 chr6:28176104 NA 0.51 7.25 0.37 3.05e-12 Parkinson's disease; CRC cis rs1008375 1.000 rs2872959 chr4:17677163 G/A cg16339924 chr4:17578868 LAP3 -0.54 -7.12 -0.37 7.01e-12 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs616402 0.527 rs604369 chr1:10567208 C/A cg17425144 chr1:10567563 PEX14 0.59 13.66 0.6 5.61e-34 Breast size; CRC cis rs1046896 0.594 rs8070403 chr17:80865404 A/G cg19046167 chr17:80928561 B3GNTL1 0.49 6.83 0.35 4.14e-11 Glycated hemoglobin levels; CRC cis rs9733 0.688 rs12725667 chr1:150766070 A/T cg18016565 chr1:150552671 MCL1 -0.39 -5.65 -0.3 3.42e-8 Tonsillectomy; CRC cis rs4713118 0.911 rs9295746 chr6:27730064 T/C cg25164649 chr6:28176230 NA 0.66 8.12 0.41 9.72e-15 Parkinson's disease; CRC cis rs300703 0.935 rs4241316 chr2:252197 A/G cg21211680 chr2:198530 NA -0.88 -8.1 -0.41 1.12e-14 Blood protein levels; CRC cis rs1997103 1.000 rs4947500 chr7:55407270 C/A cg17469321 chr7:55412551 NA 0.72 11.28 0.53 3.48e-25 QRS interval (sulfonylurea treatment interaction); CRC cis rs1552244 0.882 rs6443279 chr3:10053599 C/A cg16606324 chr3:10149918 C3orf24 0.64 8.2 0.41 5.35e-15 Alzheimer's disease; CRC cis rs11229555 0.609 rs12286421 chr11:58174898 A/G cg15696309 chr11:58395628 NA -0.81 -10.45 -0.5 2.9e-22 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; CRC cis rs4332037 0.539 rs11762636 chr7:2061111 C/A cg02825527 chr7:2087843 MAD1L1 -0.47 -5.71 -0.3 2.51e-8 Bipolar disorder; CRC cis rs6461049 0.608 rs3800923 chr7:2184673 A/G cg08027265 chr7:2291960 NA -0.33 -5.74 -0.3 2.19e-8 Schizophrenia; CRC cis rs9902453 0.765 rs2729436 chr17:28120670 C/G cg26525008 chr17:28256777 EFCAB5;SSH2 -0.73 -12.23 -0.56 1.28e-28 Coffee consumption (cups per day); CRC cis rs12545109 0.800 rs1440763 chr8:57410481 C/A cg09654669 chr8:57350985 NA -0.41 -5.71 -0.3 2.51e-8 Obesity-related traits; CRC trans rs2727020 0.553 rs11040400 chr11:49518296 C/A cg15704280 chr7:45808275 SEPT13 -0.94 -17.3 -0.69 3.68e-48 Coronary artery disease; CRC cis rs12594515 1.000 rs8032835 chr15:45997897 C/G cg06207120 chr15:45996521 NA 0.31 7.48 0.38 6.71e-13 Waist circumference;Weight; CRC cis rs7264396 1.000 rs224433 chr20:34153850 C/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.42 -6.79 -0.35 5.4e-11 Total cholesterol levels; CRC cis rs9311474 0.508 rs11714565 chr3:52606292 C/T cg10802521 chr3:52805072 NEK4 -0.56 -8.85 -0.44 5.55e-17 Electroencephalogram traits; CRC cis rs9858542 1.000 rs9822268 chr3:49719729 G/A cg00383909 chr3:49044727 WDR6 0.47 5.89 0.31 9.55e-9 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs877282 0.853 rs12779017 chr10:763619 T/C cg17470449 chr10:769945 NA 0.65 8.51 0.42 6.25e-16 Uric acid levels; CRC cis rs68170813 0.559 rs76843318 chr7:106863173 A/G cg02696742 chr7:106810147 HBP1 -0.6 -6.58 -0.34 1.83e-10 Coronary artery disease; CRC cis rs473651 0.740 rs502349 chr2:239318389 C/T cg18131467 chr2:239335373 ASB1 0.94 18.5 0.71 7.07e-53 Multiple system atrophy; CRC cis rs7917772 0.503 rs7902306 chr10:104290462 C/T cg04362960 chr10:104952993 NT5C2 -0.47 -6.22 -0.32 1.53e-9 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC cis rs11583043 1.000 rs11583043 chr1:101466054 C/T cg16556008 chr1:101360663 SLC30A7;EXTL2 0.46 6.05 0.32 3.91e-9 Ulcerative colitis;Inflammatory bowel disease; CRC cis rs2013441 1.000 rs2526484 chr17:20103760 A/G cg13482628 chr17:19912719 NA -0.41 -6.28 -0.33 1.05e-9 Obesity-related traits; CRC cis rs9649213 0.593 rs6949718 chr7:97924483 G/A cg21770322 chr7:97807741 LMTK2 0.52 8.46 0.42 8.91e-16 Prostate cancer (SNP x SNP interaction); CRC cis rs6570726 0.738 rs7746330 chr6:145899257 A/C cg05347473 chr6:146136440 FBXO30 0.4 6.11 0.32 2.83e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs870825 0.860 rs34985821 chr4:185599489 G/A cg04058563 chr4:185651563 MLF1IP 0.64 6.59 0.34 1.75e-10 Blood protein levels; CRC cis rs123509 0.687 rs73077214 chr3:42838020 G/A cg12982090 chr3:42733453 KBTBD5 -0.56 -6.82 -0.35 4.36e-11 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs832540 0.656 rs6862118 chr5:56106474 G/A cg24531977 chr5:56204891 C5orf35 -0.52 -7.92 -0.4 3.65e-14 Coronary artery disease; CRC cis rs513349 1.000 rs210146 chr6:33549098 A/G cg24505687 chr6:33548425 BAK1 0.31 5.88 0.31 9.87e-9 Platelet count; CRC cis rs7811142 1.000 rs11761725 chr7:100039815 C/T cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.18 16.63 0.68 1.69e-45 Platelet count; CRC trans rs11098499 0.954 rs7436506 chr4:120393769 T/C cg25214090 chr10:38739885 LOC399744 0.66 10.67 0.51 5.22e-23 Corneal astigmatism; CRC cis rs10504229 0.906 rs67389108 chr8:58193718 G/A cg02290350 chr8:58132656 NA -0.42 -6.17 -0.32 2.06e-9 Developmental language disorder (linguistic errors); CRC cis rs9487051 0.872 rs1320612 chr6:109611990 C/A cg12927641 chr6:109611667 NA -0.37 -6.64 -0.34 1.33e-10 Reticulocyte fraction of red cells; CRC cis rs1178968 0.818 rs2108235 chr7:72783383 A/G cg25889504 chr7:72793014 NA 0.51 5.72 0.3 2.45e-8 Triglyceride levels; CRC cis rs6879260 1.000 rs6879260 chr5:179731014 A/G cg23221052 chr5:179740743 GFPT2 -0.62 -9.75 -0.47 6.81e-20 Height; CRC trans rs9291683 0.530 rs11723970 chr4:9980462 T/C cg26043149 chr18:55253948 FECH 0.54 8.27 0.41 3.27e-15 Bone mineral density; CRC cis rs597583 0.775 rs11216440 chr11:117406111 G/A cg27161313 chr11:117392002 DSCAML1 -0.38 -5.75 -0.3 2.03e-8 Putamen volume; CRC cis rs9894429 1.000 rs7222241 chr17:79574714 C/G cg21984481 chr17:79567631 NPLOC4 -0.52 -9.52 -0.46 3.81e-19 Eye color traits; CRC cis rs7772486 0.686 rs857882 chr6:145969716 T/G cg13319975 chr6:146136371 FBXO30 0.45 6.75 0.35 6.77e-11 Lobe attachment (rater-scored or self-reported); CRC cis rs7647973 1.000 rs10865956 chr3:49581559 C/A cg07636037 chr3:49044803 WDR6 0.68 8.24 0.41 4.22e-15 Menarche (age at onset); CRC cis rs372883 0.648 rs15092 chr21:30718201 G/A cg24692254 chr21:30365293 RNF160 -0.62 -9.39 -0.46 1.06e-18 Pancreatic cancer; CRC cis rs6831352 0.703 rs2602854 chr4:100028651 C/T cg12011299 chr4:100065546 ADH4 0.45 8.75 0.43 1.11e-16 Alcohol dependence; CRC cis rs1401999 0.714 rs13066518 chr3:183635498 T/A cg01324343 chr3:183735012 ABCC5 0.6 9.64 0.47 1.5700000000000001e-19 Anterior chamber depth; CRC cis rs763121 0.888 rs2235229 chr22:39124912 A/G cg06544989 chr22:39130855 UNC84B 0.45 7.28 0.37 2.46e-12 Menopause (age at onset); CRC cis rs854765 0.583 rs2350977 chr17:17802779 A/G cg24612305 chr17:17875800 TOM1L2;LRRC48 0.59 9.51 0.46 4.31e-19 Total body bone mineral density; CRC cis rs2204008 0.749 rs10880692 chr12:38592918 C/G cg26384229 chr12:38710491 ALG10B -0.7 -9.37 -0.46 1.18e-18 Bladder cancer; CRC cis rs13191362 1.000 rs66534429 chr6:163003322 A/G cg21926612 chr6:163149169 PACRG;PARK2 0.77 11.26 0.53 4.18e-25 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs798554 0.549 rs1623138 chr7:2899410 A/G cg13628971 chr7:2884303 GNA12 0.4 5.93 0.31 7.59e-9 Height; CRC cis rs4666002 0.957 rs1919128 chr2:27801759 A/G cg27432699 chr2:27873401 GPN1 0.46 5.77 0.3 1.83e-8 Phospholipid levels (plasma); CRC cis rs4555082 0.874 rs760270 chr14:105737785 A/G cg10792982 chr14:105748885 BRF1 0.38 6.28 0.33 1.08e-9 Mean platelet volume;Platelet distribution width; CRC cis rs798766 1.000 rs798724 chr4:1704643 C/T cg05874882 chr4:1763078 NA -0.35 -6.36 -0.33 6.75e-10 Bladder cancer;Urinary bladder cancer; CRC cis rs7580658 0.926 rs4662725 chr2:128141320 G/A cg09760422 chr2:128146352 NA -0.36 -6.9 -0.36 2.6e-11 Protein C levels; CRC trans rs925098 0.577 rs2724470 chr4:17996046 A/G cg07138452 chr17:17141020 FLCN -0.43 -6.41 -0.33 4.92e-10 Birth weight;Height; CRC cis rs6502050 0.835 rs8081783 chr17:80117388 G/A cg19223190 chr17:80058835 NA 0.39 6.25 0.33 1.27e-9 Life satisfaction; CRC cis rs637571 0.522 rs493899 chr11:65747952 A/C cg02427764 chr11:65769310 BANF1;EIF1AD 0.4 5.82 0.31 1.44e-8 Eosinophil percentage of white cells; CRC cis rs798554 0.759 rs2644291 chr7:2890456 T/C cg17321639 chr7:2759063 NA -0.5 -6.39 -0.33 5.73e-10 Height; CRC cis rs2952156 0.920 rs2934951 chr17:37833328 A/G cg11212589 chr17:38028394 ZPBP2 0.35 6.25 0.33 1.24e-9 Asthma; CRC cis rs1153858 1.000 rs9788780 chr15:45685487 T/A cg21132104 chr15:45694354 SPATA5L1 0.6 8.47 0.42 8.2e-16 Homoarginine levels; CRC trans rs11098499 0.954 rs10031665 chr4:120422852 T/C cg25214090 chr10:38739885 LOC399744 0.65 10.13 0.49 3.7e-21 Corneal astigmatism; CRC cis rs7085104 0.632 rs3781287 chr10:104595420 A/C cg11453585 chr10:104263688 ACTR1A;SUFU -0.41 -5.71 -0.3 2.49e-8 Immature fraction of reticulocytes;Schizophrenia; CRC cis rs8032158 1.000 rs28770330 chr15:56248743 T/G cg02198044 chr15:56286336 NEDD4 -0.43 -6.26 -0.33 1.22e-9 Keloid; CRC cis rs2739330 0.731 rs5751792 chr22:24401542 G/A cg11060661 chr22:24314208 DDT;DDTL 0.44 7.77 0.39 1.01e-13 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs3740540 0.507 rs897292 chr10:126290035 A/G cg04949429 chr10:126290192 LHPP 0.44 6.39 0.33 5.59e-10 Obesity-related traits;Acute lymphoblastic leukemia (childhood); CRC cis rs9457247 0.967 rs1211447 chr6:167381979 C/T cg23791538 chr6:167370224 RNASET2 -0.38 -5.97 -0.31 6.08e-9 Crohn's disease; CRC trans rs4591358 0.689 rs2173773 chr2:196414425 T/G cg12742475 chr15:75233485 NA 0.3 5.96 0.31 6.4e-9 Adverse response to chemotherapy (neutropenia/leucopenia) (all antimicrotubule drugs); CRC trans rs9291683 0.566 rs13144709 chr4:10044182 C/T cg26043149 chr18:55253948 FECH 0.51 7.63 0.39 2.62e-13 Bone mineral density; CRC cis rs2762353 0.595 rs12207313 chr6:25741027 G/C cg15691649 chr6:25882328 NA 0.48 6.26 0.33 1.23e-9 Blood metabolite levels; CRC cis rs9549260 0.564 rs9549270 chr13:41284193 G/T cg21288729 chr13:41239152 FOXO1 0.41 6.2 0.32 1.69e-9 Red blood cell count; CRC cis rs6938 0.514 rs56338926 chr15:75259335 C/A cg14664628 chr15:75095509 CSK -0.53 -7.49 -0.38 6.3e-13 Breast cancer; CRC cis rs6952808 0.594 rs3778964 chr7:2138109 C/T cg04267008 chr7:1944627 MAD1L1 -0.67 -9.28 -0.46 2.28e-18 Bipolar disorder and schizophrenia; CRC cis rs875971 0.862 rs6460307 chr7:66060871 A/G cg12463550 chr7:65579703 CRCP 0.44 5.92 0.31 7.96e-9 Aortic root size; CRC cis rs8038465 0.592 rs58443257 chr15:73930707 A/T cg15420318 chr15:73925796 NPTN 0.41 6.32 0.33 8.64e-10 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs10504229 0.593 rs79615400 chr8:57988740 C/T cg21724239 chr8:58056113 NA 0.75 9.05 0.45 1.3e-17 Developmental language disorder (linguistic errors); CRC cis rs4713118 0.699 rs200978 chr6:27853168 C/G cg06470822 chr6:28175283 NA 0.85 11.24 0.53 5.08e-25 Parkinson's disease; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg00677986 chr12:80084523 PAWR 0.39 6.39 0.33 5.65e-10 Liver disease severity in Alagille syndrome; CRC cis rs3816788 0.792 rs7013323 chr8:21869024 C/G cg16476235 chr8:21771668 DOK2 0.33 5.65 0.3 3.49e-8 Lung cancer in ever smokers; CRC cis rs4629710 0.592 rs749375 chr6:131553692 C/G cg12606694 chr6:131520996 AKAP7 0.56 8.22 0.41 4.75e-15 Multiple myeloma (IgH translocation); CRC cis rs6564851 0.506 rs7204019 chr16:81253015 G/A cg05274606 chr16:81253692 PKD1L2 -0.36 -5.94 -0.31 7.09e-9 Carotenoid and tocopherol levels; CRC cis rs875971 1.000 rs1565531 chr7:65663113 T/A cg11764359 chr7:65958608 NA -0.61 -9.82 -0.48 4.04e-20 Aortic root size; CRC trans rs1997103 1.000 rs6593233 chr7:55406200 C/T cg20935933 chr6:143382018 AIG1 -0.52 -6.89 -0.36 2.9100000000000002e-11 QRS interval (sulfonylurea treatment interaction); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg12030002 chr3:61237226 FHIT 0.43 6.43 0.33 4.54e-10 Intelligence (multi-trait analysis); CRC cis rs6963495 0.818 rs1355614 chr7:105179176 A/G cg19920283 chr7:105172520 RINT1 0.53 6.65 0.34 1.25e-10 Bipolar disorder (body mass index interaction); CRC cis rs898097 0.841 rs2271918 chr17:80861206 A/G cg16060761 chr17:80687452 NA 0.46 6.52 0.34 2.68e-10 Breast cancer; CRC trans rs12699921 0.632 rs2691609 chr7:17881162 C/T cg15753394 chr6:17282781 RBM24 -0.36 -6.09 -0.32 3.19e-9 Fibrinogen levels; CRC cis rs6951245 0.745 rs79788515 chr7:1101079 C/T cg18402987 chr7:1209562 NA 0.67 7.14 0.37 5.91e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs11212617 0.869 rs12801988 chr11:108357747 C/T cg14761454 chr11:108092087 ATM;NPAT -0.4 -5.81 -0.31 1.48e-8 Response to metformin in type 2 diabetes (glycemic); CRC trans rs7395662 0.591 rs4882110 chr11:48558249 G/T cg15704280 chr7:45808275 SEPT13 -0.48 -6.83 -0.35 4.04e-11 HDL cholesterol; CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg14089512 chr10:102106757 SCD 0.4 6.46 0.34 3.68e-10 Obesity-related traits; CRC cis rs11971779 0.680 rs66491565 chr7:139088977 C/G cg07862535 chr7:139043722 LUC7L2 0.82 10.66 0.51 5.69e-23 Diisocyanate-induced asthma; CRC cis rs6502050 0.835 rs34620191 chr17:80149532 G/A cg13198984 chr17:80129470 CCDC57 0.43 7.56 0.38 3.92e-13 Life satisfaction; CRC cis rs7551222 0.749 rs11240761 chr1:204566700 C/A cg07972458 chr1:204535000 NA 0.37 5.67 0.3 3.07e-8 Schizophrenia; CRC cis rs1005277 0.579 rs9418322 chr10:38377296 G/T cg25427524 chr10:38739819 LOC399744 -0.77 -13.56 -0.6 1.36e-33 Extrinsic epigenetic age acceleration; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg20024234 chr21:43431083 ZNF295 0.46 6.73 0.35 7.41e-11 Anxiety disorder; CRC cis rs4964805 0.594 rs10861096 chr12:104169356 C/T cg02344784 chr12:104178138 NT5DC3 0.47 7.2 0.37 4.14e-12 Attention deficit hyperactivity disorder; CRC cis rs7945705 0.875 rs10769957 chr11:8809016 A/C cg14711859 chr11:8959438 ASCL3 0.37 5.8 0.3 1.52e-8 Hemoglobin concentration; CRC cis rs9549367 0.713 rs9549691 chr13:113861606 A/C cg24300038 chr13:113819356 PROZ -0.44 -5.68 -0.3 3.02e-8 Platelet distribution width; CRC cis rs875971 1.000 rs1167411 chr7:65539264 C/G cg18912574 chr7:65842487 NCRNA00174 -0.38 -6.46 -0.34 3.71e-10 Aortic root size; CRC trans rs6951245 0.872 rs76161580 chr7:1100307 G/T cg13565492 chr6:43139072 SRF -0.72 -7.44 -0.38 8.63e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs1218582 0.772 rs4845682 chr1:154877105 T/C cg03351412 chr1:154909251 PMVK 0.54 8.68 0.43 1.92e-16 Prostate cancer; CRC cis rs524281 0.861 rs7120326 chr11:65849256 C/T cg16950941 chr11:66035639 RAB1B -0.61 -7.47 -0.38 7.24e-13 Electroencephalogram traits; CRC cis rs62229266 0.563 rs6517325 chr21:37434978 T/C cg08632701 chr21:37451849 NA -0.42 -6.53 -0.34 2.48e-10 Mitral valve prolapse; CRC trans rs2797160 1.000 rs1739374 chr6:126011825 C/T cg05039488 chr6:79577232 IRAK1BP1 0.5 7.52 0.38 5.13e-13 Endometrial cancer; CRC cis rs76993477 0.666 rs76487956 chr1:169717555 C/A cg03211132 chr1:169703751 SELE 0.61 5.83 0.31 1.32e-8 Tonsillectomy; CRC cis rs11212617 0.935 rs664143 chr11:108225661 C/T cg01991180 chr11:108092276 ATM;NPAT -0.43 -6.18 -0.32 1.89e-9 Response to metformin in type 2 diabetes (glycemic); CRC cis rs7949030 0.626 rs71490390 chr11:62329185 A/G cg13298116 chr11:62369859 EML3;MTA2 0.61 10.89 0.51 8.54e-24 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; CRC trans rs916888 0.647 rs199524 chr17:44848438 G/T cg22433210 chr17:43662623 NA -0.58 -7.05 -0.36 1.06e-11 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC trans rs1455244 0.700 rs7229302 chr18:11508904 G/T cg10691036 chr19:49622443 C19orf73;PPFIA3 0.41 6.19 0.32 1.77e-9 Schizophrenia; CRC cis rs1797885 0.714 rs299661 chr3:12554069 A/G cg07775309 chr3:12595852 NA 0.32 5.78 0.3 1.75e-8 Immature fraction of reticulocytes; CRC cis rs7824557 0.583 rs2736292 chr8:11234500 A/T cg08265495 chr8:11212668 TDH 0.34 6.06 0.32 3.67e-9 Retinal vascular caliber; CRC cis rs2836950 0.545 rs8132424 chr21:40584412 A/T cg11644478 chr21:40555479 PSMG1 0.49 7.28 0.37 2.5e-12 Menarche (age at onset); CRC cis rs7589728 0.563 rs80324973 chr2:88447264 T/G cg24977027 chr2:88469347 THNSL2 0.64 7.72 0.39 1.37e-13 Plasma clusterin levels; CRC cis rs8078723 0.701 rs2305482 chr17:38140927 A/C cg17344932 chr17:38183730 MED24;SNORD124 0.48 7.9 0.4 4.23e-14 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); CRC cis rs2276314 0.762 rs3826600 chr18:33609053 A/G cg05985134 chr18:33552581 C18orf21 0.46 6.26 0.33 1.22e-9 Endometriosis;Drug-induced torsades de pointes; CRC cis rs4665809 0.590 rs7586047 chr2:26447335 A/G cg26119090 chr2:26468346 HADHA;HADHB -1.06 -15.5 -0.65 4.69e-41 Gut microbiome composition (summer); CRC cis rs9303401 0.659 rs34426768 chr17:56683385 C/T cg02118635 chr17:56770003 RAD51C;TEX14 0.82 9.69 0.47 1.07e-19 Cognitive test performance; CRC cis rs116095464 0.558 rs62346526 chr5:220614 T/C cg22496380 chr5:211416 CCDC127 -0.83 -9.55 -0.47 3.03e-19 Breast cancer; CRC cis rs853679 0.517 rs9468298 chr6:28122345 A/G cg06470822 chr6:28175283 NA 1.03 13.59 0.6 1.04e-33 Depression; CRC cis rs6973256 0.568 rs7800126 chr7:133521356 A/C cg03336402 chr7:133662267 EXOC4 -0.41 -5.84 -0.31 1.27e-8 Intelligence (multi-trait analysis); CRC cis rs11098499 0.820 rs13122709 chr4:120555356 T/A cg24375607 chr4:120327624 NA 0.53 7.97 0.4 2.61e-14 Corneal astigmatism; CRC cis rs1580019 0.961 rs766660 chr7:32499077 A/G cg07520158 chr7:32535189 LSM5;AVL9 0.46 6.52 0.34 2.6e-10 Cognitive ability; CRC cis rs425277 0.583 rs3107151 chr1:2051513 T/G cg19257562 chr1:2043853 PRKCZ 0.4 6.56 0.34 2.09e-10 Height; CRC trans rs4276421 0.806 rs6860200 chr5:45440343 G/T cg04793272 chr11:119020941 ABCG4 -0.37 -6.11 -0.32 2.82e-9 P wave duration; CRC cis rs897984 0.572 rs4889526 chr16:31030344 C/A cg02466173 chr16:30829666 NA -0.61 -9.2 -0.45 4.32e-18 Dementia with Lewy bodies; CRC cis rs11148252 0.574 rs7139495 chr13:53283318 A/G cg12458913 chr13:53173898 NA 0.76 13.84 0.61 1.2e-34 Lewy body disease; CRC cis rs10832963 1.000 rs11024739 chr11:18645843 A/C cg20219074 chr11:18656078 SPTY2D1 -0.6 -8.6 -0.43 3.31e-16 Breast cancer; CRC cis rs1451375 0.698 rs56766899 chr7:50648938 T/C cg14593290 chr7:50529359 DDC 0.51 7.11 0.37 7.09e-12 Malaria; CRC cis rs2635047 0.638 rs2571008 chr18:44649950 T/C cg23996704 chr18:44553084 KATNAL2 -0.29 -5.66 -0.3 3.29e-8 Educational attainment; CRC cis rs6121246 0.954 rs7266148 chr20:30431070 G/T cg13852791 chr20:30311386 BCL2L1 0.67 10.5 0.5 2.03e-22 Mean corpuscular hemoglobin; CRC cis rs13108904 0.870 rs12642797 chr4:1245990 G/A cg16405210 chr4:1374714 KIAA1530 -0.43 -6.1 -0.32 3.06e-9 Obesity-related traits; CRC trans rs561341 0.739 rs8070554 chr17:30216868 A/T cg20587970 chr11:113659929 NA 0.63 8.19 0.41 5.88e-15 Hip circumference adjusted for BMI; CRC cis rs7937682 0.889 rs578022 chr11:111490552 G/T cg19812747 chr11:111475976 SIK2 -0.59 -10.14 -0.49 3.31e-21 Primary sclerosing cholangitis; CRC cis rs7632954 0.596 rs9858072 chr3:8508515 T/C cg03495237 chr3:8533978 NA 0.33 6.2 0.32 1.74e-9 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs7927771 0.524 rs3816605 chr11:47857253 T/C cg20307385 chr11:47447363 PSMC3 0.46 6.69 0.35 9.65e-11 Subjective well-being; CRC cis rs6500395 0.775 rs4277341 chr16:48664387 T/G cg04672837 chr16:48644449 N4BP1 0.44 6.53 0.34 2.53e-10 Response to tocilizumab in rheumatoid arthritis; CRC cis rs12410462 1.000 rs75198003 chr1:227623853 C/A cg23173402 chr1:227635558 NA 0.71 8.03 0.4 1.71e-14 Major depressive disorder; CRC cis rs7568458 0.709 rs762684 chr2:85782023 G/A cg02493740 chr2:85810744 VAMP5 -0.55 -8.3 -0.42 2.75e-15 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); CRC cis rs3806843 1.000 rs991918 chr5:140194858 C/T cg19875535 chr5:140030758 IK 0.61 10.06 0.48 6.42e-21 Depressive symptoms (multi-trait analysis); CRC cis rs11123170 0.529 rs1015753 chr2:113968803 T/G cg12889195 chr2:113992843 PAX8;LOC440839;LOC654433 0.49 5.81 0.3 1.49e-8 Renal function-related traits (BUN); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg24371536 chr6:79943342 HMGN3 0.5 7.18 0.37 4.7e-12 Response to antipsychotic treatment; CRC cis rs10484885 0.514 rs10944450 chr6:90228498 A/G cg13799429 chr6:90582589 CASP8AP2 -0.55 -6.26 -0.33 1.17e-9 QRS interval (sulfonylurea treatment interaction); CRC cis rs11098499 0.818 rs10008791 chr4:120431469 A/C cg24375607 chr4:120327624 NA 0.47 7.17 0.37 5.06e-12 Corneal astigmatism; CRC cis rs2576037 0.623 rs2576040 chr18:44582027 A/G cg23996704 chr18:44553084 KATNAL2 0.37 7.42 0.38 1.03e-12 Personality dimensions; CRC cis rs7591163 1.000 rs4487084 chr2:228713179 G/A cg14646075 chr2:228736089 WDR69 -0.45 -6.14 -0.32 2.43e-9 Blood pressure; CRC trans rs66573146 1.000 rs9942188 chr4:6984181 C/T cg07817883 chr1:32538562 TMEM39B 1.51 13.4 0.59 5.67e-33 Granulocyte percentage of myeloid white cells; CRC cis rs995000 0.931 rs11207984 chr1:63013396 C/T cg19896129 chr1:63156450 NA -0.44 -6.82 -0.35 4.3e-11 Triglyceride levels; CRC cis rs2811415 0.597 rs6808774 chr3:127759090 G/A cg13719885 chr3:127795394 NA -0.37 -5.67 -0.3 3.19e-8 Lung function (FEV1/FVC); CRC cis rs539096 0.624 rs499257 chr1:44078384 T/C cg12908607 chr1:44402522 ARTN -0.37 -6.62 -0.34 1.45e-10 Intelligence (multi-trait analysis); CRC cis rs9393692 0.905 rs6908328 chr6:26292855 C/A cg13736514 chr6:26305472 NA -0.62 -11.53 -0.54 4.55e-26 Educational attainment; CRC cis rs35828350 1 rs35828350 chr15:85355841 G/A cg17507749 chr15:85114479 UBE2QP1 0.58 7.77 0.39 1.03e-13 Autism spectrum disorder or schizophrenia; CRC cis rs34779708 0.931 rs17591135 chr10:35465190 T/A cg03585969 chr10:35415529 CREM 0.62 8.35 0.42 1.98e-15 Inflammatory bowel disease;Crohn's disease; CRC cis rs6952808 0.595 rs3800916 chr7:2166072 C/T cg21782813 chr7:2030301 MAD1L1 0.56 9.77 0.47 5.81e-20 Bipolar disorder and schizophrenia; CRC cis rs875971 0.522 rs1701760 chr7:65473688 A/G cg00343986 chr7:65444356 GUSB 0.58 8.79 0.44 8.29e-17 Aortic root size; CRC cis rs6951245 1.000 rs76804143 chr7:1082021 C/T cg24642844 chr7:1081250 C7orf50 -0.78 -9.34 -0.46 1.44e-18 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs8072100 0.713 rs1912486 chr17:45515167 A/G cg25173405 chr17:45401733 C17orf57 -0.43 -6.44 -0.33 4.13e-10 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs9914988 0.778 rs35398767 chr17:27122960 A/T cg12682573 chr17:27188876 MIR451;MIR144 0.58 7.99 0.4 2.37e-14 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs9858542 0.953 rs9824092 chr3:49674147 C/G cg03060546 chr3:49711283 APEH -0.5 -6.65 -0.34 1.23e-10 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs10256972 0.552 rs2960837 chr7:1203957 A/G cg07092213 chr7:1199455 ZFAND2A -0.49 -7.08 -0.36 8.8e-12 Longevity;Endometriosis; CRC cis rs7412746 0.611 rs11204747 chr1:150927152 A/G cg10589385 chr1:150898437 SETDB1 -0.27 -5.8 -0.3 1.56e-8 Melanoma; CRC cis rs9916302 0.904 rs35285898 chr17:37555872 A/C cg07936489 chr17:37558343 FBXL20 0.85 13.38 0.59 6.93e-33 Glomerular filtration rate (creatinine); CRC cis rs2066819 1.000 rs79750959 chr12:56702012 C/A cg26714650 chr12:56694279 CS -1.38 -11.56 -0.54 3.59e-26 Psoriasis vulgaris; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg00000769 chr12:124086477 DDX55 0.39 6.1 0.32 2.92e-9 Liver disease severity in Alagille syndrome; CRC trans rs7944735 0.507 rs10742827 chr11:48102350 C/T cg15704280 chr7:45808275 SEPT13 0.64 8.3 0.42 2.64e-15 Intraocular pressure; CRC cis rs57221529 0.709 rs111352378 chr5:577079 G/A cg17948913 chr5:572064 NA 0.56 6.25 0.33 1.28e-9 Lung disease severity in cystic fibrosis; CRC cis rs1448094 0.511 rs59858864 chr12:86166404 G/A cg00310523 chr12:86230176 RASSF9 0.38 6.05 0.32 3.86e-9 Major depressive disorder; CRC cis rs9649213 0.613 rs6961129 chr7:97975542 T/G cg21770322 chr7:97807741 LMTK2 0.52 8.5 0.42 6.78e-16 Prostate cancer (SNP x SNP interaction); CRC cis rs9487051 0.872 rs9480923 chr6:109607369 G/C cg12927641 chr6:109611667 NA -0.39 -7.0 -0.36 1.45e-11 Reticulocyte fraction of red cells; CRC cis rs9463078 0.691 rs1852986 chr6:45329489 C/G cg25276700 chr6:44698697 NA -0.23 -5.66 -0.3 3.26e-8 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; CRC cis rs1448094 0.872 rs7314272 chr12:86401005 T/C cg02569458 chr12:86230093 RASSF9 0.4 6.72 0.35 8.2e-11 Major depressive disorder; CRC cis rs5750830 0.649 rs4821894 chr22:39809820 G/C cg25459000 chr22:39777742 SYNGR1 -0.34 -5.96 -0.31 6.32e-9 Intelligence (multi-trait analysis); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg05300939 chr11:44587523 CD82 0.44 6.41 0.33 5.1e-10 Response to antipsychotic treatment; CRC cis rs9649213 0.593 rs6961438 chr7:98005849 T/C cg00277769 chr7:97922759 BAIAP2L1 -0.59 -10.37 -0.5 5.4e-22 Prostate cancer (SNP x SNP interaction); CRC cis rs910316 0.687 rs175059 chr14:75490667 T/C cg08847533 chr14:75593920 NEK9 -0.84 -14.47 -0.62 4.42e-37 Height; CRC cis rs10504229 0.683 rs11786843 chr8:58133629 T/C cg02725872 chr8:58115012 NA -0.64 -11.39 -0.53 1.41e-25 Developmental language disorder (linguistic errors); CRC cis rs7618501 0.602 rs2071206 chr3:50160109 G/A cg24308560 chr3:49941425 MST1R 0.54 9.1 0.45 8.91e-18 Intelligence (multi-trait analysis); CRC cis rs1401999 0.966 rs2313212 chr3:183700928 A/G cg20387954 chr3:183756860 HTR3D 0.45 7.69 0.39 1.72e-13 Anterior chamber depth; CRC cis rs2842992 0.789 rs10945635 chr6:160214487 C/A cg11366901 chr6:160182831 ACAT2 0.98 14.11 0.61 1.13e-35 Age-related macular degeneration (geographic atrophy); CRC cis rs10927875 0.894 rs10927878 chr1:16319957 C/T cg21385522 chr1:16154831 NA -0.59 -7.5 -0.38 5.91e-13 Dilated cardiomyopathy; CRC cis rs6951245 1.000 rs78185801 chr7:1096367 G/A cg22907277 chr7:1156413 C7orf50 0.72 7.6 0.39 3.1400000000000003e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs9611565 0.685 rs169363 chr22:41853117 G/T cg06481639 chr22:41940642 POLR3H 0.48 5.92 0.31 7.97e-9 Vitiligo; CRC cis rs40363 0.645 rs1690447 chr16:3519211 T/C cg00484396 chr16:3507460 NAT15 0.55 7.87 0.4 5.09e-14 Tuberculosis; CRC cis rs1552244 1.000 rs17032278 chr3:10077955 A/G cg02579736 chr3:10068473 FANCD2;CIDECP 1.05 14.06 0.61 1.71e-35 Alzheimer's disease; CRC cis rs12144309 0.554 rs2476599 chr1:114363459 G/A cg03325407 chr1:114423726 BCL2L15 0.35 6.47 0.34 3.48e-10 Coronary artery disease; CRC cis rs2072499 0.966 rs2853641 chr1:156181770 A/G cg06970220 chr1:156163860 SLC25A44 0.47 6.73 0.35 7.73e-11 Testicular germ cell tumor; CRC cis rs7107174 1.000 rs58565853 chr11:78036707 C/T cg02023728 chr11:77925099 USP35 0.49 8.3 0.42 2.7e-15 Testicular germ cell tumor; CRC cis rs807669 0.586 rs5746671 chr22:19160899 A/G cg02655711 chr22:19163373 SLC25A1 0.63 10.61 0.5 8.04e-23 Metabolite levels; CRC cis rs9470366 0.883 rs7756236 chr6:36627053 A/G cg08179530 chr6:36648295 CDKN1A 0.52 6.32 0.33 8.39e-10 QRS duration; CRC cis rs853679 0.699 rs9468318 chr6:28209531 T/A cg02683197 chr6:28174875 NA 0.64 6.54 0.34 2.37e-10 Depression; CRC cis rs4838594 0.590 rs1867579 chr10:49671394 A/G cg17291251 chr10:49678358 ARHGAP22 -0.38 -5.89 -0.31 9.33e-9 Daytime sleep phenotypes; CRC cis rs28829049 0.597 rs12745238 chr1:19393710 C/T cg22333259 chr1:19394757 NA 0.37 6.03 0.32 4.31e-9 QRS duration in Tripanosoma cruzi seropositivity; CRC cis rs427941 0.585 rs201511 chr7:101767653 A/G cg06246474 chr7:101738831 CUX1 0.45 6.92 0.36 2.41e-11 Plasma omega-3 polyunsaturated fatty acid level (eicosapentaenoic acid); CRC cis rs826838 0.935 rs11169547 chr12:39185625 C/A cg26384229 chr12:38710491 ALG10B 0.69 9.33 0.46 1.61e-18 Heart rate; CRC cis rs77956314 0.515 rs12299065 chr12:117442304 A/G cg25972092 chr12:117363249 FBXW8 0.51 6.03 0.32 4.39e-9 Subcortical brain region volumes;Hippocampal volume; CRC cis rs9326248 0.817 rs1242127 chr11:117076564 A/G cg15534755 chr11:117069859 TAGLN -0.34 -6.19 -0.32 1.75e-9 Blood protein levels; CRC cis rs7772486 0.764 rs2247211 chr6:146216379 G/A cg23711669 chr6:146136114 FBXO30 0.66 11.25 0.53 4.47e-25 Lobe attachment (rater-scored or self-reported); CRC cis rs7772486 0.875 rs6938972 chr6:146410608 G/A cg23711669 chr6:146136114 FBXO30 0.66 11.42 0.53 1.1e-25 Lobe attachment (rater-scored or self-reported); CRC cis rs17818399 0.788 rs13013245 chr2:46806086 T/C cg21681030 chr2:46777652 RHOQ 0.42 5.97 0.31 6.07e-9 Height; CRC cis rs1129187 0.755 rs13215983 chr6:42924193 C/T cg26304593 chr6:42947056 PEX6 -0.46 -6.76 -0.35 6.47e-11 Alzheimer's disease in APOE e4+ carriers; CRC cis rs875971 0.660 rs801193 chr7:66030612 A/C cg11764359 chr7:65958608 NA -0.54 -8.53 -0.43 5.29e-16 Aortic root size; CRC trans rs12699921 0.632 rs2723545 chr7:17859691 C/A cg02066331 chr6:17282778 RBM24 -0.35 -6.03 -0.32 4.3e-9 Fibrinogen levels; CRC cis rs1552244 1.000 rs6442148 chr3:10078289 G/C cg18598329 chr3:10140678 FANCD2;C3orf24 -0.89 -12.94 -0.58 2.96e-31 Alzheimer's disease; CRC cis rs9303280 0.806 rs10852936 chr17:38031714 C/T cg00129232 chr17:37814104 STARD3 -0.45 -7.1 -0.36 7.74e-12 Self-reported allergy; CRC cis rs56235845 0.694 rs11749830 chr5:176766547 G/A cg16006841 chr5:176797999 RGS14 0.53 8.55 0.43 4.78e-16 Hemoglobin concentration;Hematocrit; CRC trans rs2303319 0.504 rs961421 chr2:162626099 G/C cg10272801 chr16:14013773 ERCC4 -0.68 -6.07 -0.32 3.49e-9 Cognitive function; CRC cis rs3126085 0.877 rs1552996 chr1:152171104 C/A cg09127314 chr1:152161683 NA 0.52 6.53 0.34 2.53e-10 Atopic dermatitis; CRC cis rs12249377 0.519 rs11599902 chr10:92598823 A/G cg14313238 chr10:92632228 RPP30 0.46 6.44 0.33 4.28e-10 White matter microstructure (global fractional anisotropy); CRC cis rs7666738 0.830 rs10000573 chr4:99048785 G/C cg17366294 chr4:99064904 C4orf37 0.45 7.75 0.39 1.16e-13 Colonoscopy-negative controls vs population controls; CRC cis rs1401999 0.659 rs4912518 chr3:183752027 C/T cg01324343 chr3:183735012 ABCC5 -0.63 -10.53 -0.5 1.49e-22 Anterior chamber depth; CRC cis rs7615952 0.736 rs9866347 chr3:125669925 C/T cg05084668 chr3:125655381 ALG1L -0.85 -12.32 -0.56 6.07e-29 Blood pressure (smoking interaction); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg02010524 chr4:57333365 SRP72 0.55 7.81 0.4 7.58e-14 Response to antipsychotic treatment; CRC trans rs7144011 0.654 rs4903847 chr14:79854832 A/G cg27114086 chr1:155658701 YY1AP1;DAP3 -0.45 -6.64 -0.34 1.28e-10 Waist circumference;Hip circumference; CRC cis rs6076065 0.723 rs2424541 chr20:23386776 T/C cg11657817 chr20:23433608 CST11 0.44 6.51 0.34 2.89e-10 Facial morphology (factor 15, philtrum width); CRC cis rs9486719 0.843 rs2499789 chr6:96844510 T/C cg06623918 chr6:96969491 KIAA0776 0.79 8.57 0.43 4.23e-16 Migraine;Coronary artery disease; CRC cis rs1223397 0.651 rs2496142 chr6:13311794 C/T cg07912922 chr6:13274314 PHACTR1 -0.39 -6.05 -0.32 3.96e-9 Blood pressure; CRC cis rs9894429 0.646 rs7405937 chr17:79597811 G/A cg21028142 chr17:79581711 NPLOC4 0.34 7.14 0.37 5.88e-12 Eye color traits; CRC trans rs1864585 0.520 rs17776946 chr8:10682674 A/C cg26278703 chr11:58910052 FAM111A 0.56 7.05 0.36 1.07e-11 Neutrophil percentage of white cells;Lymphocyte percentage of white cells; CRC cis rs7584330 0.740 rs11896232 chr2:238438124 T/C cg14458575 chr2:238380390 NA 0.51 9.03 0.45 1.46e-17 Prostate cancer; CRC cis rs853679 0.517 rs11552219 chr6:28126834 C/T cg03623178 chr6:28175578 NA 0.98 12.66 0.57 3.31e-30 Depression; CRC cis rs888194 0.649 rs10774697 chr12:109875981 A/G cg19025524 chr12:109796872 NA -0.39 -5.71 -0.3 2.52e-8 Neuroticism; CRC cis rs16858210 0.826 rs35494670 chr3:183606357 T/G cg25686905 chr3:183603175 PARL -0.44 -6.23 -0.32 1.44e-9 Menopause (age at onset); CRC cis rs9311474 0.508 rs17052256 chr3:52593119 A/G cg18099408 chr3:52552593 STAB1 -0.48 -8.31 -0.42 2.48e-15 Electroencephalogram traits; CRC cis rs10128264 1.000 rs2802364 chr10:80960486 G/C cg18737081 chr10:80999807 ZMIZ1 -0.33 -5.86 -0.31 1.12e-8 Response to methotrexate in juvenile idiopathic arthritis; CRC cis rs2832191 0.511 rs7278227 chr21:30482707 C/T cg24692254 chr21:30365293 RNF160 -0.55 -8.09 -0.41 1.14e-14 Dental caries; CRC cis rs1008375 1.000 rs555 chr4:17625658 A/G cg16339924 chr4:17578868 LAP3 0.55 7.46 0.38 7.83e-13 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs6088590 0.965 rs6088620 chr20:33412022 A/G cg24642439 chr20:33292090 TP53INP2 0.58 10.22 0.49 1.81e-21 Coronary artery disease; CRC cis rs11098499 0.604 rs10022185 chr4:120571765 C/G cg24375607 chr4:120327624 NA 0.5 7.5 0.38 5.94e-13 Corneal astigmatism; CRC cis rs3820068 0.581 rs72645877 chr1:15928106 G/T cg24675056 chr1:15929824 NA 0.49 6.77 0.35 5.87e-11 Systolic blood pressure; CRC cis rs7666738 0.830 rs10009943 chr4:99021475 G/A cg05340658 chr4:99064831 C4orf37 0.61 9.51 0.46 4.05e-19 Colonoscopy-negative controls vs population controls; CRC cis rs7208859 0.673 rs11655623 chr17:29162173 T/C cg13385521 chr17:29058706 SUZ12P 0.63 7.45 0.38 8.04e-13 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs10791097 0.568 rs4411284 chr11:130738568 A/C cg12179176 chr11:130786555 SNX19 0.73 12.15 0.56 2.67e-28 Autism spectrum disorder or schizophrenia;Schizophrenia; CRC cis rs1552244 1.000 rs55882090 chr3:10139082 C/T cg16606324 chr3:10149918 C3orf24 0.69 9.75 0.47 6.97e-20 Alzheimer's disease; CRC cis rs863345 0.967 rs7534319 chr1:158532295 G/C cg12129480 chr1:158549410 OR10X1 -0.26 -5.66 -0.3 3.32e-8 Pneumococcal bacteremia; CRC trans rs564309 0.681 rs2230656 chr1:228612838 G/T cg24066601 chr6:26271455 HIST1H3G -0.57 -6.47 -0.34 3.47e-10 Hip circumference (psychosocial stress interaction); CRC cis rs853679 0.517 rs9468292 chr6:28095355 G/A cg12172441 chr6:28176163 NA 0.62 7.4 0.38 1.17e-12 Depression; CRC cis rs35883536 0.967 rs1577509 chr1:101089253 C/T cg14515779 chr1:101123966 NA -0.43 -8.39 -0.42 1.49e-15 Monocyte count; CRC cis rs875971 0.545 rs1909508 chr7:65766353 G/T cg05627663 chr7:65219948 SNORA22;CCT6P1 0.56 7.34 0.38 1.66e-12 Aortic root size; CRC trans rs17126268 0.502 rs1856774 chr1:102876232 T/C cg18468354 chr14:36993517 NA 0.39 6.14 0.32 2.37e-9 Glomerular filtration rate; CRC cis rs6089584 0.889 rs6142923 chr20:60596617 C/T cg06108461 chr20:60628389 TAF4 0.83 12.25 0.56 1.11e-28 Body mass index; CRC cis rs17376456 0.542 rs17083380 chr5:93170476 C/G cg09848695 chr5:92956644 FAM172A;MIR2277 -0.45 -5.86 -0.31 1.12e-8 Diabetic retinopathy; CRC cis rs172166 0.538 rs1150686 chr6:28161271 T/G cg03623178 chr6:28175578 NA 0.67 10.21 0.49 1.89e-21 Cardiac Troponin-T levels; CRC cis rs2153535 0.580 rs1414345 chr6:8471537 T/G cg07606381 chr6:8435919 SLC35B3 0.68 10.89 0.51 8.84e-24 Motion sickness; CRC cis rs6693567 0.545 rs1260385 chr1:150316385 G/A cg15654264 chr1:150340011 RPRD2 0.42 6.29 0.33 1.04e-9 Migraine; CRC cis rs7772486 0.754 rs9399561 chr6:145955687 C/G cg13319975 chr6:146136371 FBXO30 -0.42 -6.09 -0.32 3.13e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs7945705 0.869 rs2742471 chr11:9003953 C/T cg12365402 chr11:9010492 NRIP3 -0.57 -10.29 -0.49 1.01e-21 Hemoglobin concentration; CRC cis rs9462027 0.606 rs1201874 chr6:34549810 T/C cg07306190 chr6:34760872 UHRF1BP1 -0.34 -5.94 -0.31 7.44e-9 Systemic lupus erythematosus; CRC trans rs17685 0.753 rs4398845 chr7:75716781 G/A cg19862616 chr7:65841803 NCRNA00174 0.99 18.25 0.71 7e-52 Coffee consumption;Coffee consumption (cups per day); CRC cis rs2153535 0.563 rs1737586 chr6:8535897 C/T cg21535247 chr6:8435926 SLC35B3 0.5 7.72 0.39 1.44e-13 Motion sickness; CRC cis rs6866344 0.697 rs62392823 chr5:178126968 T/C cg10224037 chr5:178157518 ZNF354A 0.78 11.45 0.53 9.28e-26 Neutrophil percentage of white cells; CRC cis rs17376456 0.825 rs36042718 chr5:93180997 C/T cg09848695 chr5:92956644 FAM172A;MIR2277 0.71 6.31 0.33 8.84e-10 Diabetic retinopathy; CRC cis rs7727544 0.735 rs273914 chr5:131660431 A/T cg24060327 chr5:131705240 SLC22A5 -0.36 -6.02 -0.31 4.7e-9 Blood metabolite levels; CRC cis rs853679 0.517 rs9468286 chr6:28079428 C/T cg18032046 chr6:28092343 ZSCAN16 -0.52 -6.02 -0.31 4.76e-9 Depression; CRC cis rs2243480 1.000 rs458291 chr7:65520479 C/A cg18252515 chr7:66147081 NA -1.17 -12.86 -0.58 5.92e-31 Diabetic kidney disease; CRC cis rs7224685 0.501 rs7222628 chr17:3890429 A/G cg10724054 chr17:3904396 NA -0.45 -7.27 -0.37 2.7e-12 Type 2 diabetes; CRC cis rs796364 0.951 rs2881593 chr2:201000347 A/G cg25936922 chr2:200820526 C2orf60;C2orf47 -0.62 -7.1 -0.36 7.51e-12 Schizophrenia; CRC cis rs7666738 1.000 rs1426673 chr4:98924024 G/A cg05340658 chr4:99064831 C4orf37 0.52 7.4 0.38 1.17e-12 Colonoscopy-negative controls vs population controls; CRC trans rs12599106 0.648 rs12447240 chr16:34928236 C/T cg01516881 chr6:292596 DUSP22 0.66 9.62 0.47 1.76e-19 Menopause (age at onset); CRC cis rs12325245 0.536 rs34129245 chr16:58588191 A/G cg19824325 chr16:58548873 SETD6 0.9 6.09 0.32 3.09e-9 Schizophrenia; CRC cis rs10779751 0.922 rs2746638 chr1:11278125 T/C cg08854313 chr1:11322531 MTOR 0.63 9.01 0.44 1.68e-17 Body mass index; CRC cis rs6951245 1.000 rs1997243 chr7:1083777 A/G cg22907277 chr7:1156413 C7orf50 0.72 7.47 0.38 7.14e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs1044826 0.692 rs188421 chr3:139234066 A/C cg00490450 chr3:139108681 COPB2 -0.43 -6.49 -0.34 3.11e-10 Obesity-related traits; CRC cis rs7811142 1.000 rs1073 chr7:100031612 G/A cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.99 13.25 0.59 2.02e-32 Platelet count; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg17027945 chr15:74284732 STOML1 0.53 6.92 0.36 2.35e-11 Thyroid stimulating hormone; CRC trans rs747782 0.585 rs1316604 chr11:48279796 G/A cg03929089 chr4:120376271 NA 0.68 6.7 0.35 8.92e-11 Intraocular pressure; CRC cis rs4474465 1.000 rs7124043 chr11:78205644 G/T cg27205649 chr11:78285834 NARS2 0.47 5.79 0.3 1.61e-8 Alzheimer's disease (survival time); CRC cis rs2882667 0.931 rs10075893 chr5:138355871 A/G cg04439458 chr5:138467593 SIL1 0.32 5.75 0.3 1.99e-8 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs2243480 1.000 rs1499614 chr7:65730798 A/T cg12463550 chr7:65579703 CRCP 0.63 5.67 0.3 3.2e-8 Diabetic kidney disease; CRC cis rs7927771 1.000 rs4752856 chr11:47648042 C/T cg20307385 chr11:47447363 PSMC3 -0.56 -7.87 -0.4 5.02e-14 Subjective well-being; CRC cis rs10896135 0.526 rs624561 chr11:66414915 C/T cg24851651 chr11:66362959 CCS -0.5 -8.31 -0.42 2.61e-15 Bipolar disorder; CRC cis rs6570726 0.846 rs453834 chr6:145886261 T/C cg23711669 chr6:146136114 FBXO30 0.67 11.33 0.53 2.35e-25 Lobe attachment (rater-scored or self-reported); CRC cis rs2243480 1.000 rs7795242 chr7:65390094 T/C cg18252515 chr7:66147081 NA -1.08 -12.66 -0.57 3.44e-30 Diabetic kidney disease; CRC trans rs9929218 1.000 rs12446575 chr16:68791644 C/G cg04657470 chr2:198365150 HSPE1;HSPD1 -0.94 -13.83 -0.61 1.35e-34 Colorectal cancer; CRC cis rs3859192 0.561 rs12451547 chr17:38181168 T/C cg17344932 chr17:38183730 MED24;SNORD124 0.84 16.62 0.68 1.87e-45 White blood cell count; CRC cis rs17253792 0.822 rs10135426 chr14:56054644 A/G cg24579896 chr14:56047964 C14orf33;KTN1 0.67 5.7 0.3 2.61e-8 Putamen volume; CRC cis rs2243480 1.000 rs13247184 chr7:65358928 A/G cg12463550 chr7:65579703 CRCP 0.71 6.53 0.34 2.52e-10 Diabetic kidney disease; CRC cis rs9467711 0.591 rs13208859 chr6:25894609 G/A cg19084075 chr6:26124329 HIST1H2AC;HIST1H2BC 0.75 5.78 0.3 1.72e-8 Autism spectrum disorder or schizophrenia; CRC trans rs1031925 0.687 rs6778196 chr3:51770429 C/T cg21573611 chr7:89975649 GTPBP10 0.65 6.24 0.33 1.32e-9 Melanoma; CRC cis rs270601 0.633 rs733300 chr5:131572243 A/G cg22638593 chr5:131593259 PDLIM4 0.52 9.08 0.45 1e-17 Acylcarnitine levels; CRC trans rs1549309 0.767 rs9313387 chr5:167173269 C/T cg24963307 chr14:21979594 METTL3 0.51 6.01 0.31 4.82e-9 Dietary macronutrient intake; CRC trans rs1814175 0.669 rs12416837 chr11:49669761 G/T cg15704280 chr7:45808275 SEPT13 -0.7 -11.14 -0.52 1.18e-24 Height; CRC cis rs10463316 0.709 rs3857426 chr5:150789831 C/A cg03212797 chr5:150827313 SLC36A1 -0.48 -7.29 -0.37 2.39e-12 Metabolite levels (Pyroglutamine); CRC trans rs853679 0.546 rs200954 chr6:27838764 C/G cg16898833 chr6:26189333 HIST1H4D 0.72 6.45 0.34 4.08e-10 Depression; CRC cis rs2739330 0.760 rs5751760 chr22:24243573 G/A cg24846343 chr22:24311635 DDTL 0.72 11.62 0.54 2.11e-26 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs6424115 0.931 rs2982390 chr1:24147830 G/C cg15997130 chr1:24165203 NA 0.75 11.44 0.53 9.61e-26 Immature fraction of reticulocytes; CRC cis rs1348850 0.874 rs4893822 chr2:178285727 G/T cg27490568 chr2:178487706 NA 0.43 6.2 0.32 1.66e-9 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs868943 0.743 rs1890425 chr6:116339295 T/C cg26893134 chr6:116381904 FRK 0.27 6.46 0.34 3.67e-10 Total cholesterol levels; CRC trans rs2243480 1.000 rs1701750 chr7:65467145 T/C cg10756647 chr7:56101905 PSPH 0.73 7.98 0.4 2.44e-14 Diabetic kidney disease; CRC cis rs28386778 0.797 rs4968664 chr17:61851366 C/G cg22520471 chr17:61851767 DDX42;CCDC47 0.74 11.55 0.54 3.91e-26 Prudent dietary pattern; CRC cis rs7219014 1 rs7219014 chr17:37624790 A/G cg03013999 chr17:37608204 MED1 0.43 6.36 0.33 6.78e-10 Urinary metabolites; CRC cis rs116095464 0.558 rs13357299 chr5:242211 T/C cg22857025 chr5:266934 NA -1.19 -16.12 -0.66 1.68e-43 Breast cancer; CRC cis rs6499255 0.904 rs7187653 chr16:69562838 G/C cg04110750 chr16:69646130 NFAT5 -0.52 -7.23 -0.37 3.48e-12 IgE levels; CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg03270376 chr2:219536588 RNF25;STK36 -0.57 -6.94 -0.36 2.1e-11 Diisocyanate-induced asthma; CRC cis rs2859741 0.587 rs516139 chr1:37471617 C/G cg09363841 chr1:37513479 NA -0.48 -8.06 -0.41 1.42e-14 Forced expiratory volume in 1 second (environmental tobacco smoke interaction); CRC cis rs138880 0.580 rs28562884 chr22:50312869 T/C cg02269571 chr22:50332266 NA -0.9 -9.15 -0.45 5.93e-18 Schizophrenia; CRC trans rs116095464 0.558 rs61492827 chr5:225774 A/G cg00938859 chr5:1591904 SDHAP3 0.7 7.63 0.39 2.58e-13 Breast cancer; CRC cis rs929354 0.772 rs3802126 chr7:156970281 G/A cg17757837 chr7:157058334 UBE3C 0.74 12.39 0.56 3.31e-29 Body mass index; CRC cis rs17095355 1.000 rs12247564 chr10:111721400 G/A cg00817464 chr10:111662876 XPNPEP1 -0.62 -8.44 -0.42 1e-15 Biliary atresia; CRC cis rs7659604 1.000 rs28433617 chr4:122664138 C/A cg20573242 chr4:122745356 CCNA2 0.42 6.31 0.33 8.84e-10 Type 2 diabetes; CRC cis rs9616064 0.740 rs6520049 chr22:46996309 C/T cg05621596 chr22:47072043 GRAMD4 -0.43 -6.8 -0.35 4.81e-11 Urate levels in obese individuals; CRC cis rs28386778 0.897 rs7210443 chr17:61785374 A/G cg23090583 chr17:61904693 PSMC5;FTSJ3 1.04 19.51 0.73 7.46e-57 Prudent dietary pattern; CRC cis rs6952808 0.609 rs12699449 chr7:1951227 G/C cg04267008 chr7:1944627 MAD1L1 -0.66 -10.35 -0.5 6.5e-22 Bipolar disorder and schizophrenia; CRC cis rs3806843 1.000 rs10057161 chr5:140156831 C/T cg19875535 chr5:140030758 IK 0.6 9.76 0.47 6.11e-20 Depressive symptoms (multi-trait analysis); CRC trans rs2727020 0.675 rs7929401 chr11:49350832 C/A cg15704280 chr7:45808275 SEPT13 -0.67 -8.24 -0.41 4.18e-15 Coronary artery disease; CRC cis rs7945718 0.905 rs10831908 chr11:12812419 G/A cg25843174 chr11:12811716 TEAD1 0.52 9.73 0.47 8.05e-20 Educational attainment (years of education); CRC cis rs853679 0.517 rs9380050 chr6:28048538 A/G cg12963246 chr6:28129442 ZNF389 0.47 5.61 0.3 4.26e-8 Depression; CRC cis rs1005277 0.602 rs1740743 chr10:38519222 C/T cg00409905 chr10:38381863 ZNF37A -0.62 -10.29 -0.49 1.04e-21 Extrinsic epigenetic age acceleration; CRC cis rs17125944 0.505 rs75838476 chr14:53242362 G/A cg00686598 chr14:53173677 PSMC6 1.23 11.33 0.53 2.5e-25 Alzheimer's disease (late onset); CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg06496078 chr12:107350075 C12orf23 0.48 6.31 0.33 9.11e-10 Thyroid stimulating hormone; CRC cis rs919433 0.617 rs10931791 chr2:198573612 A/C cg00792783 chr2:198669748 PLCL1 -0.31 -5.69 -0.3 2.86e-8 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg08429159 chr1:6663269 KLHL21 0.47 6.58 0.34 1.88e-10 Response to antipsychotic treatment; CRC cis rs877282 0.853 rs7079450 chr10:755932 T/A cg17470449 chr10:769945 NA 0.61 7.96 0.4 2.78e-14 Uric acid levels; CRC cis rs1223397 0.651 rs202016 chr6:13301043 G/A cg07912922 chr6:13274314 PHACTR1 0.37 5.71 0.3 2.53e-8 Blood pressure; CRC cis rs67478160 0.595 rs12889993 chr14:104274294 A/G cg01849466 chr14:104193079 ZFYVE21 -0.46 -8.11 -0.41 1.01e-14 Schizophrenia; CRC cis rs6815814 0.861 rs28690449 chr4:38789132 C/T cg06935464 chr4:38784597 TLR10 0.68 8.9 0.44 3.88e-17 Breast cancer; CRC trans rs9291683 0.597 rs11723016 chr4:10126189 A/G cg26043149 chr18:55253948 FECH -0.56 -8.7 -0.43 1.57e-16 Bone mineral density; CRC cis rs477895 0.713 rs12787852 chr11:63954648 G/A cg05016508 chr11:63871570 FLRT1;MACROD1 0.54 6.96 0.36 1.84e-11 Mean platelet volume; CRC cis rs1832871 0.643 rs9456282 chr6:158724743 A/G cg07165851 chr6:158734300 TULP4 0.64 7.73 0.39 1.32e-13 Height; CRC cis rs1865760 0.519 rs2275904 chr6:25768085 T/C cg16482183 chr6:26056742 HIST1H1C 0.78 9.76 0.47 6.31e-20 Height; CRC cis rs394563 0.967 rs444784 chr6:149798366 C/G cg11245181 chr6:149772854 ZC3H12D -0.53 -8.77 -0.44 9.48e-17 Dupuytren's disease; CRC cis rs870825 0.929 rs10003354 chr4:185589782 G/A cg07424746 chr4:185654737 MLF1IP -0.58 -5.71 -0.3 2.56e-8 Blood protein levels; CRC cis rs2108622 0.727 rs12611308 chr19:15978586 C/T cg13772218 chr19:15982569 NA 0.48 6.72 0.35 8.16e-11 Circulating phylloquinone levels;Vitamin E levels;Acenocoumarol maintenance dosage;Response to Vitamin E supplementation;Metabolite levels;Warfarin maintenance dose; CRC cis rs10540 1.000 rs35898083 chr11:484469 C/T cg03576123 chr11:487126 PTDSS2 -1.03 -10.3 -0.49 9.36e-22 Body mass index; CRC cis rs6500395 0.962 rs9922356 chr16:48640025 C/T cg04672837 chr16:48644449 N4BP1 0.42 5.83 0.31 1.31e-8 Response to tocilizumab in rheumatoid arthritis; CRC cis rs7666738 0.830 rs28522896 chr4:99008243 C/T cg17366294 chr4:99064904 C4orf37 0.44 7.39 0.38 1.19e-12 Colonoscopy-negative controls vs population controls; CRC cis rs57590327 0.527 rs11917558 chr3:81610805 G/A cg07356753 chr3:81810745 GBE1 -0.52 -6.78 -0.35 5.42e-11 Extraversion; CRC cis rs6582630 0.537 rs7299661 chr12:38527713 C/T cg26384229 chr12:38710491 ALG10B 0.69 9.91 0.48 1.92e-20 Drug-induced liver injury (flucloxacillin); CRC cis rs10504229 0.953 rs115634610 chr8:58190533 G/A cg02290350 chr8:58132656 NA -0.42 -5.98 -0.31 5.73e-9 Developmental language disorder (linguistic errors); CRC cis rs1552244 0.872 rs7646073 chr3:10097405 G/A cg13047869 chr3:10149882 C3orf24 0.53 7.44 0.38 8.73e-13 Alzheimer's disease; CRC cis rs9388451 0.874 rs9398787 chr6:126090608 A/G cg05901451 chr6:126070800 HEY2 -0.65 -11.11 -0.52 1.43e-24 Brugada syndrome; CRC cis rs7647973 1.000 rs940045 chr3:49449638 G/A cg20833759 chr3:49053208 WDR6;DALRD3 0.57 8.81 0.44 7.28e-17 Menarche (age at onset); CRC cis rs6500602 0.928 rs3747581 chr16:4462619 A/G cg08645402 chr16:4508243 NA 0.59 9.74 0.47 7.57e-20 Schizophrenia; CRC cis rs1005277 0.541 rs2472177 chr10:38384015 T/G cg03665457 chr10:38645376 HSD17B7P2 -0.42 -6.02 -0.32 4.57e-9 Extrinsic epigenetic age acceleration; CRC cis rs1957429 0.901 rs1951490 chr14:65346957 G/T cg23373153 chr14:65346875 NA 0.77 7.83 0.4 6.98e-14 Pediatric areal bone mineral density (radius); CRC cis rs3018066 0.640 rs4337798 chr4:107029008 G/A cg01869342 chr4:106983673 TBCK 0.46 6.01 0.31 4.84e-9 Cancer; CRC cis rs1218582 0.741 rs11264291 chr1:154914797 C/T cg24250549 chr1:154909240 PMVK 0.61 10.08 0.49 5.25e-21 Prostate cancer; CRC cis rs6120849 0.663 rs6119548 chr20:33552612 A/G cg08999081 chr20:33150536 PIGU 0.44 5.74 0.3 2.18e-8 Protein C levels; CRC cis rs41271473 0.526 rs56043220 chr1:228783474 G/C cg16512390 chr1:228756714 NA 0.63 6.59 0.34 1.71e-10 Chronic lymphocytic leukemia; CRC cis rs3806843 1.000 rs10066278 chr5:140156318 A/C cg16607685 chr5:140181889 PCDHA2;PCDHA1;PCDHA3 -0.27 -6.09 -0.32 3.07e-9 Depressive symptoms (multi-trait analysis); CRC trans rs9858542 0.953 rs11711485 chr3:49491983 G/T cg21665057 chr3:196295764 WDR53;FBXO45 -0.66 -8.94 -0.44 2.94e-17 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs875971 0.862 rs12698526 chr7:65969105 T/C cg00343986 chr7:65444356 GUSB 0.45 6.26 0.33 1.19e-9 Aortic root size; CRC cis rs7945718 0.875 rs9888178 chr11:12782643 C/T cg25843174 chr11:12811716 TEAD1 0.49 9.34 0.46 1.49e-18 Educational attainment (years of education); CRC cis rs4713118 0.869 rs9283882 chr6:27715258 A/C cg12273811 chr6:28175739 NA 0.54 7.72 0.39 1.43e-13 Parkinson's disease; CRC trans rs459571 1.000 rs459571 chr9:136912626 C/T cg15028160 chr19:49622717 PPFIA3;C19orf73 -0.57 -6.99 -0.36 1.58e-11 Platelet distribution width; CRC cis rs6860806 0.661 rs3763112 chr5:131586480 A/G cg18758796 chr5:131593413 PDLIM4 0.44 8.06 0.41 1.39e-14 Breast cancer; CRC trans rs2303319 0.504 rs62188960 chr2:162492578 A/C cg10272801 chr16:14013773 ERCC4 -0.69 -6.06 -0.32 3.8e-9 Cognitive function; CRC cis rs11122272 0.735 rs2572249 chr1:231514829 G/A cg06096015 chr1:231504339 EGLN1 0.38 5.64 0.3 3.66e-8 Hemoglobin concentration; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg26671183 chr1:207226604 PFKFB2 0.39 6.44 0.33 4.33e-10 Liver disease severity in Alagille syndrome; CRC cis rs1552244 0.882 rs6796419 chr3:10040812 G/A cg10729496 chr3:10149963 C3orf24 0.45 6.13 0.32 2.57e-9 Alzheimer's disease; CRC cis rs7274811 0.681 rs291670 chr20:31945861 G/A cg03904042 chr20:32255491 NECAB3;C20orf134 0.44 6.37 0.33 6.21e-10 Height; CRC cis rs898097 0.578 rs9906163 chr17:80908174 T/C cg03160526 chr17:80928410 B3GNTL1 0.5 8.3 0.42 2.64e-15 Breast cancer; CRC cis rs2204008 0.754 rs11181643 chr12:38380553 G/A cg13010199 chr12:38710504 ALG10B 0.47 6.3 0.33 9.3e-10 Bladder cancer; CRC cis rs10504229 0.871 rs10504227 chr8:58162005 G/A cg24829409 chr8:58192753 C8orf71 -0.58 -9.74 -0.47 7.04e-20 Developmental language disorder (linguistic errors); CRC cis rs7833790 0.724 rs6473299 chr8:82676936 A/G cg17211192 chr8:82754475 SNX16 -0.5 -6.23 -0.33 1.39e-9 Diastolic blood pressure; CRC cis rs12368653 1.000 rs12371356 chr12:58135420 T/C cg00677455 chr12:58241039 CTDSP2 -0.59 -8.88 -0.44 4.48e-17 Multiple sclerosis; CRC cis rs7539542 0.556 rs6662413 chr1:202888496 C/T cg19681188 chr1:202830198 LOC148709 -0.43 -6.17 -0.32 2.03e-9 Mean platelet volume; CRC cis rs853679 0.517 rs9380059 chr6:28132358 A/C cg12963246 chr6:28129442 ZNF389 0.49 5.7 0.3 2.71e-8 Depression; CRC cis rs3091242 0.933 rs7541095 chr1:25761291 T/C cg27572855 chr1:25598939 RHD 0.35 6.11 0.32 2.76e-9 Erythrocyte sedimentation rate; CRC cis rs3857067 0.772 rs4692999 chr4:95107644 T/C cg11021082 chr4:95130006 SMARCAD1 -0.5 -7.82 -0.4 7.41e-14 QT interval; CRC cis rs3858526 0.752 rs11040173 chr11:6009378 A/G cg05234568 chr11:5960015 NA 0.45 5.78 0.3 1.7e-8 DNA methylation (variation); CRC cis rs2717559 0.683 rs2717611 chr8:143879927 C/T cg15511327 chr8:143859410 LYNX1 -0.44 -7.93 -0.4 3.45e-14 Urinary tract infection frequency; CRC cis rs2739330 0.828 rs5760108 chr22:24252668 G/T cg10150615 chr22:24372951 LOC391322 -0.64 -9.85 -0.48 3.1e-20 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs3741404 0.620 rs11231722 chr11:63967770 C/G cg06219103 chr11:63990595 FERMT3 -0.44 -7.01 -0.36 1.39e-11 Platelet count; CRC cis rs6502050 0.835 rs4789754 chr17:80091941 C/T cg13198984 chr17:80129470 CCDC57 0.47 8.29 0.42 2.83e-15 Life satisfaction; CRC cis rs7412746 0.503 rs72704639 chr1:150798335 A/C cg04414720 chr1:150670196 GOLPH3L 0.4 5.71 0.3 2.46e-8 Melanoma; CRC cis rs2070488 0.965 rs2154778 chr3:38553639 C/T cg01465620 chr3:38496096 LOC100128640;ACVR2B -0.89 -16.46 -0.67 7.51e-45 Electrocardiographic conduction measures; CRC cis rs4689388 0.853 rs6446479 chr4:6291737 G/C cg25554036 chr4:6271136 WFS1 0.54 8.54 0.43 5.04e-16 Type 2 diabetes and other traits;Type 2 diabetes; CRC cis rs651907 0.535 rs58658478 chr3:101511667 G/A cg11279151 chr3:101281821 RG9MTD1 -0.52 -6.97 -0.36 1.74e-11 Colorectal cancer; CRC cis rs611744 0.647 rs702808 chr8:109252554 T/C cg21045802 chr8:109455806 TTC35 0.42 6.68 0.35 1.05e-10 Dupuytren's disease; CRC cis rs9916302 0.851 rs11868029 chr17:37650304 A/G cg20243544 chr17:37824526 PNMT 0.41 5.63 0.3 3.83e-8 Glomerular filtration rate (creatinine); CRC cis rs916888 0.610 rs199446 chr17:44813169 G/A cg15921436 chr17:44337874 NA -0.51 -6.7 -0.35 8.93e-11 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs59104589 0.617 rs56390510 chr2:242274489 G/C cg19488206 chr2:242435732 STK25 0.47 6.75 0.35 6.67e-11 Fibrinogen levels; CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg19472759 chr11:69456837 CCND1 0.37 6.02 0.31 4.56e-9 Obesity-related traits; CRC cis rs950169 0.541 rs10795 chr15:85177297 G/A cg11189052 chr15:85197271 WDR73 0.65 9.36 0.46 1.25e-18 Schizophrenia; CRC cis rs4713118 0.869 rs4713121 chr6:27722064 T/C cg20933634 chr6:27740509 NA 0.57 7.33 0.37 1.76e-12 Parkinson's disease; CRC cis rs2252790 0.764 rs2027851 chr6:116681682 C/G cg18764771 chr6:116381957 FRK -0.22 -6.03 -0.32 4.34e-9 Fast beta electroencephalogram; CRC cis rs6693567 0.586 rs12031973 chr1:150485566 T/G cg15654264 chr1:150340011 RPRD2 0.39 5.61 0.3 4.35e-8 Migraine; CRC cis rs17270561 0.609 rs17267614 chr6:25730027 A/C cg16482183 chr6:26056742 HIST1H1C 0.82 10.12 0.49 3.96e-21 Iron status biomarkers; CRC cis rs2836974 0.627 rs7278985 chr21:40653767 C/T cg06238570 chr21:40685208 BRWD1 -0.81 -12.91 -0.58 4.11e-31 Cognitive function; CRC cis rs6586163 0.546 rs12359362 chr10:90753145 G/C cg13456138 chr10:90753195 FAS 0.41 5.73 0.3 2.29e-8 Chronic lymphocytic leukemia; CRC cis rs12540874 0.529 rs732215 chr7:50544063 A/C cg14593290 chr7:50529359 DDC -0.48 -6.82 -0.35 4.39e-11 Systemic sclerosis; CRC cis rs929354 1.000 rs1182385 chr7:157040583 C/T cg16102536 chr7:156981717 UBE3C -0.38 -6.49 -0.34 3.1e-10 Body mass index; CRC cis rs704795 0.902 rs11887784 chr2:27679919 A/G cg12648201 chr2:27665141 KRTCAP3 -0.31 -6.0 -0.31 5.15e-9 Menopause (age at onset); CRC cis rs311392 0.902 rs411839 chr8:55092189 T/C cg20636351 chr8:55087400 NA -0.34 -6.07 -0.32 3.51e-9 Pelvic organ prolapse (moderate/severe); CRC cis rs972578 0.806 rs4822212 chr22:43267873 G/T cg01576275 chr22:43409880 NA -0.41 -6.42 -0.33 4.73e-10 Mean platelet volume; CRC cis rs2836974 0.897 rs2836932 chr21:40546717 G/A cg06238570 chr21:40685208 BRWD1 0.76 10.62 0.51 7.3e-23 Cognitive function; CRC cis rs7727544 0.684 rs2631363 chr5:131707095 A/G cg07395648 chr5:131743802 NA 0.42 6.63 0.34 1.36e-10 Blood metabolite levels; CRC cis rs6582630 0.502 rs7311700 chr12:38463232 T/A cg13010199 chr12:38710504 ALG10B 0.47 5.99 0.31 5.57e-9 Drug-induced liver injury (flucloxacillin); CRC cis rs10504229 0.683 rs72650849 chr8:58140323 A/G cg02725872 chr8:58115012 NA -0.64 -11.55 -0.54 3.85e-26 Developmental language disorder (linguistic errors); CRC cis rs9905704 0.918 rs36071323 chr17:56916804 C/T cg12560992 chr17:57184187 TRIM37 0.53 7.37 0.38 1.35e-12 Testicular germ cell tumor; CRC cis rs9467711 0.659 rs36162392 chr6:26569135 T/C cg12315302 chr6:26189340 HIST1H4D 0.99 6.94 0.36 2.04e-11 Autism spectrum disorder or schizophrenia; CRC cis rs910316 0.935 rs3742771 chr14:75599647 A/G cg08847533 chr14:75593920 NEK9 0.93 17.35 0.69 2.49e-48 Height; CRC cis rs9916302 0.904 rs3964723 chr17:37403979 C/T cg00129232 chr17:37814104 STARD3 -0.54 -7.85 -0.4 5.97e-14 Glomerular filtration rate (creatinine); CRC cis rs57221529 0.709 rs72707023 chr5:667620 G/A cg14541582 chr5:601475 NA -0.34 -6.4 -0.33 5.46e-10 Lung disease severity in cystic fibrosis; CRC cis rs796364 0.951 rs971232 chr2:200792881 C/T cg23649088 chr2:200775458 C2orf69 0.55 6.01 0.31 4.94e-9 Schizophrenia; CRC cis rs4481887 0.927 rs10788779 chr1:248481661 C/G cg13385794 chr1:248469461 NA 0.4 7.1 0.36 7.54e-12 Common traits (Other); CRC cis rs11690935 0.632 rs2292816 chr2:172586714 G/C cg13550731 chr2:172543902 DYNC1I2 0.69 10.35 0.5 6.61e-22 Schizophrenia; CRC cis rs2067615 0.524 rs1922436 chr12:107065258 A/G cg13491945 chr12:107078410 RFX4 0.33 5.7 0.3 2.73e-8 Heart rate; CRC cis rs4665809 0.590 rs3806515 chr2:26466975 C/T cg27170947 chr2:26402098 FAM59B 0.59 7.71 0.39 1.53e-13 Gut microbiome composition (summer); CRC cis rs35110281 0.667 rs4819285 chr21:45118970 C/T cg21573476 chr21:45109991 RRP1B 0.38 5.75 0.3 2e-8 Mean corpuscular volume; CRC trans rs951252 0.504 rs11734405 chr4:146081096 C/T cg01470323 chr11:66139715 SLC29A2 0.49 6.45 0.34 3.93e-10 Hip circumference; CRC trans rs11581859 0.950 rs7529505 chr1:99362556 C/T cg12183875 chr3:169587454 LRRC31 0.25 5.99 0.31 5.39e-9 Response to cognitive-behavioural therapy in anxiety disorder; CRC cis rs9733 0.596 rs12077833 chr1:150674333 C/T cg15448220 chr1:150897856 SETDB1 0.46 6.51 0.34 2.88e-10 Tonsillectomy; CRC trans rs3942852 0.806 rs4752807 chr11:48128751 T/G cg03929089 chr4:120376271 NA -0.56 -7.19 -0.37 4.3e-12 Acute lymphoblastic leukemia (childhood); CRC cis rs1707322 0.686 rs2152078 chr1:46055600 C/T cg03146154 chr1:46216737 IPP -0.66 -9.47 -0.46 5.59e-19 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs9733 0.650 rs9803935 chr1:150552622 T/G cg18016565 chr1:150552671 MCL1 -0.46 -7.06 -0.36 1.01e-11 Tonsillectomy; CRC cis rs8072100 0.840 rs56952963 chr17:45493826 T/C cg08085267 chr17:45401833 C17orf57 -0.66 -10.75 -0.51 2.65e-23 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs2032447 0.839 rs199751 chr6:26015583 T/C cg12588279 chr6:26043732 HIST1H2BB 0.49 7.09 0.36 8.44e-12 Intelligence (multi-trait analysis); CRC cis rs7558233 0.614 rs6544858 chr2:23676071 C/T cg00747342 chr2:23700632 KLHL29 -0.55 -5.7 -0.3 2.67e-8 Cannabis use (initiation); CRC cis rs10254118 0.757 rs6467491 chr7:133138761 A/G cg10665199 chr7:133106180 EXOC4 0.68 10.37 0.5 5.68e-22 Intelligence (multi-trait analysis); CRC cis rs2576037 0.526 rs998819 chr18:44564181 C/T cg07416455 chr18:44543612 TCEB3CL;KATNAL2 0.66 10.35 0.5 6.18e-22 Personality dimensions; CRC cis rs2227564 0.672 rs10824042 chr10:75645628 C/T cg00564723 chr10:75632066 CAMK2G -0.34 -7.77 -0.39 9.98e-14 Crohn's disease;Inflammatory bowel disease; CRC cis rs11122272 0.735 rs2486729 chr1:231535584 C/T cg06096015 chr1:231504339 EGLN1 0.41 6.21 0.32 1.64e-9 Hemoglobin concentration; CRC cis rs875971 0.545 rs316323 chr7:65610989 C/T cg18876405 chr7:65276391 NA -0.44 -6.11 -0.32 2.75e-9 Aortic root size; CRC trans rs9341835 0.681 rs9352960 chr6:64150426 C/G cg13657004 chr13:50234944 EBPL -0.36 -6.08 -0.32 3.38e-9 Schizophrenia; CRC cis rs9768139 0.708 rs896782 chr7:158114115 G/A cg24154853 chr7:158122151 PTPRN2 0.59 9.88 0.48 2.43e-20 Calcium levels; CRC cis rs7811142 1.000 rs11763414 chr7:100016844 C/G cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.75 10.19 0.49 2.27e-21 Platelet count; CRC cis rs13118159 0.550 rs13123016 chr4:1340889 T/C cg02475777 chr4:1388615 CRIPAK 0.53 6.64 0.34 1.27e-10 Longevity; CRC cis rs9733 0.519 rs12095002 chr1:150649249 G/A cg17724175 chr1:150552817 MCL1 0.58 9.4 0.46 9.25e-19 Tonsillectomy; CRC cis rs13217239 0.646 rs12523820 chr6:27001502 A/G cg18867708 chr6:26865862 GUSBL1 0.37 5.67 0.3 3.09e-8 Schizophrenia; CRC cis rs4665809 0.567 rs6711402 chr2:26430983 A/G cg26119090 chr2:26468346 HADHA;HADHB -0.99 -12.64 -0.57 4.01e-30 Gut microbiome composition (summer); CRC cis rs9399135 0.967 rs7766189 chr6:135353851 A/C cg22676075 chr6:135203613 NA 0.41 6.39 0.33 5.63e-10 Red blood cell count; CRC cis rs9783347 1.000 rs10734259 chr11:18314865 A/G cg15585147 chr11:18324498 HPS5 0.43 5.98 0.31 5.75e-9 Pancreatic cancer; CRC cis rs9747201 0.963 rs4789729 chr17:80146089 G/A cg14673194 chr17:80132900 CCDC57 -0.5 -6.48 -0.34 3.44e-10 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs12580194 0.593 rs7489047 chr12:55759851 A/G cg23425280 chr12:56401806 NA 0.48 5.8 0.3 1.55e-8 Cancer; CRC cis rs3806843 0.735 rs778595 chr5:140036681 G/A cg19875535 chr5:140030758 IK -0.63 -10.38 -0.5 5e-22 Depressive symptoms (multi-trait analysis); CRC cis rs60843830 0.964 rs62114538 chr2:256116 G/T cg00108164 chr2:264199 ACP1;SH3YL1 0.6 9.62 0.47 1.8e-19 Spherical equivalent (joint analysis main effects and education interaction); CRC cis rs3936840 0.539 rs11850701 chr14:102983857 G/A cg18135206 chr14:102964638 TECPR2 0.49 6.06 0.32 3.77e-9 Plateletcrit; CRC cis rs1552244 1.000 rs1552244 chr3:10135577 A/G cg08888203 chr3:10149979 C3orf24 0.67 9.36 0.46 1.25e-18 Alzheimer's disease; CRC cis rs1799949 1.000 rs8176297 chr17:41203325 T/A cg01879757 chr17:41196368 BRCA1 -0.41 -6.26 -0.33 1.24e-9 Menopause (age at onset); CRC cis rs7465272 1.000 rs7835613 chr8:143682428 C/T cg19438565 chr8:143695827 ARC -0.45 -6.63 -0.34 1.35e-10 Bipolar disorder and schizophrenia; CRC cis rs11212617 0.967 rs227072 chr11:108212093 A/C cg14761454 chr11:108092087 ATM;NPAT 0.43 6.55 0.34 2.19e-10 Response to metformin in type 2 diabetes (glycemic); CRC cis rs1976403 0.659 rs10799701 chr1:21820990 A/G cg02390115 chr1:21767211 NBPF3 0.55 8.49 0.42 7.28e-16 Liver enzyme levels (alkaline phosphatase); CRC cis rs62408225 1.000 rs2021716 chr6:90941289 C/T cg06866423 chr6:90926672 BACH2 0.53 8.6 0.43 3.3e-16 Eosinophil counts;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC cis rs10504229 0.861 rs57942497 chr8:58171239 G/T cg05313129 chr8:58192883 C8orf71 -0.47 -6.99 -0.36 1.49e-11 Developmental language disorder (linguistic errors); CRC trans rs1656966 1.000 rs1656966 chr3:186466252 C/T cg21153962 chr11:57102758 SSRP1 0.4 6.13 0.32 2.55e-9 Myopia (pathological); CRC cis rs847649 0.692 rs10257317 chr7:102447056 T/C cg18108683 chr7:102477205 FBXL13 -0.67 -11.29 -0.53 3.37e-25 Morning vs. evening chronotype; CRC trans rs2243480 1.000 rs35391607 chr7:65360829 G/A cg10756647 chr7:56101905 PSPH 0.73 7.72 0.39 1.46e-13 Diabetic kidney disease; CRC cis rs2014572 0.870 rs10426580 chr19:57756221 G/A cg24459738 chr19:57751996 ZNF805 -0.53 -8.19 -0.41 5.93e-15 Hyperactive-impulsive symptoms; CRC cis rs270601 0.770 rs61352298 chr5:131600589 G/C cg02033258 chr5:131593261 PDLIM4 0.46 8.64 0.43 2.54e-16 Acylcarnitine levels; CRC cis rs1005277 0.579 rs2474586 chr10:38418882 T/C cg00409905 chr10:38381863 ZNF37A -0.67 -11.13 -0.52 1.21e-24 Extrinsic epigenetic age acceleration; CRC cis rs11112613 0.713 rs11112591 chr12:105951620 C/T cg03607813 chr12:105948248 NA 0.76 10.45 0.5 3.02e-22 Corrected insulin response;Corrected insulin response adjusted for insulin sensitivity index; CRC cis rs6504622 0.537 rs2920397 chr17:44997329 G/A cg16759221 chr17:45003025 GOSR2 -0.65 -10.51 -0.5 1.84e-22 Orofacial clefts; CRC cis rs2115630 1.000 rs58581703 chr15:85276935 C/T cg09876464 chr15:85330779 ZNF592 0.45 7.61 0.39 2.88e-13 P wave terminal force; CRC cis rs7551222 0.749 rs7532236 chr1:204561617 A/G cg07972458 chr1:204535000 NA -0.36 -5.7 -0.3 2.73e-8 Schizophrenia; CRC cis rs7044106 0.791 rs4837792 chr9:123483559 G/A cg09419670 chr9:123605666 PSMD5;LOC253039 0.74 12.05 0.55 6.14e-28 Hip circumference adjusted for BMI; CRC cis rs6570726 0.764 rs9403731 chr6:145907937 G/A cg05347473 chr6:146136440 FBXO30 0.38 5.81 0.3 1.51e-8 Lobe attachment (rater-scored or self-reported); CRC cis rs9649465 0.807 rs11770249 chr7:123286412 T/C cg03229431 chr7:123269106 ASB15 -0.4 -6.15 -0.32 2.21e-9 Migraine; CRC cis rs6893807 0.778 rs13162708 chr5:87943345 C/T cg09002922 chr5:87956389 LOC645323 -0.44 -5.89 -0.31 9.53e-9 Body mass index; CRC cis rs7208859 0.673 rs12103588 chr17:29197460 C/T cg13385521 chr17:29058706 SUZ12P 0.65 7.71 0.39 1.51e-13 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs995000 0.931 rs1167996 chr1:62927797 T/G cg19896129 chr1:63156450 NA -0.44 -6.73 -0.35 7.48e-11 Triglyceride levels; CRC cis rs9467711 0.591 rs34525648 chr6:25914853 G/A cg08501292 chr6:25962987 TRIM38 0.98 9.39 0.46 1.06e-18 Autism spectrum disorder or schizophrenia; CRC cis rs7618501 1.000 rs7374183 chr3:49785133 G/A cg24308560 chr3:49941425 MST1R 0.46 7.27 0.37 2.6e-12 Intelligence (multi-trait analysis); CRC cis rs1707322 1.000 rs4539075 chr1:46358010 C/T cg03146154 chr1:46216737 IPP 0.51 7.16 0.37 5.35e-12 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs736408 0.509 rs1108842 chr3:52720080 A/C cg11645453 chr3:52864694 ITIH4 0.33 6.05 0.32 4.01e-9 Bipolar disorder; CRC cis rs7119 0.717 rs12916682 chr15:77807937 A/T cg27398640 chr15:77910606 LINGO1 -0.43 -7.37 -0.38 1.39e-12 Type 2 diabetes; CRC cis rs883565 0.655 rs4676649 chr3:39064948 T/C cg01426195 chr3:39028469 NA -0.53 -8.58 -0.43 3.86e-16 Handedness; CRC cis rs6662572 0.737 rs7532388 chr1:46472734 G/A cg08644498 chr1:46502608 NA 0.46 7.38 0.38 1.29e-12 Blood protein levels; CRC cis rs4481887 0.854 rs4534423 chr1:248474993 G/C cg00666640 chr1:248458726 OR2T12 0.44 7.49 0.38 6.24e-13 Common traits (Other); CRC cis rs9393692 0.840 rs9358915 chr6:26277268 G/A cg00631329 chr6:26305371 NA -0.68 -13.44 -0.6 3.92e-33 Educational attainment; CRC cis rs60843830 1.000 rs2126129 chr2:212548 C/T cg25945732 chr2:264204 ACP1;SH3YL1 0.71 11.25 0.53 4.68e-25 Spherical equivalent (joint analysis main effects and education interaction); CRC cis rs1044826 0.619 rs57357132 chr3:139118358 A/T cg00490450 chr3:139108681 COPB2 -0.48 -7.21 -0.37 3.84e-12 Obesity-related traits; CRC trans rs10243593 0.673 rs10246466 chr7:40073341 C/T cg13911576 chr9:84174038 NA 0.34 6.0 0.31 5.32e-9 Lymphocyte counts; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg19209385 chr6:53659379 LRRC1 0.46 6.18 0.32 1.86e-9 Thyroid stimulating hormone; CRC cis rs3733585 0.699 rs6844316 chr4:9958977 A/G cg11266682 chr4:10021025 SLC2A9 -0.47 -9.67 -0.47 1.2e-19 Cleft plate (environmental tobacco smoke interaction); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg15686437 chr5:130500979 HINT1 0.44 6.44 0.33 4.15e-10 Intelligence (multi-trait analysis); CRC cis rs67478160 0.654 rs11628240 chr14:104218135 A/G cg08213375 chr14:104286397 PPP1R13B 0.65 13.76 0.6 2.47e-34 Schizophrenia; CRC cis rs9788682 1.000 rs12438181 chr15:78812098 G/A cg06917634 chr15:78832804 PSMA4 -0.54 -6.51 -0.34 2.88e-10 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; CRC cis rs3750082 0.889 rs12536400 chr7:32936390 C/G cg05721444 chr7:32995514 FKBP9 0.49 7.45 0.38 8.12e-13 Glomerular filtration rate (creatinine); CRC trans rs1814175 0.727 rs2140597 chr11:49873946 G/A cg03929089 chr4:120376271 NA -0.93 -17.64 -0.7 1.77e-49 Height; CRC cis rs13108904 0.846 rs12643212 chr4:1224948 A/G cg16405210 chr4:1374714 KIAA1530 -0.4 -5.66 -0.3 3.29e-8 Obesity-related traits; CRC cis rs7587476 0.784 rs13032278 chr2:215698034 G/A cg04004882 chr2:215674386 BARD1 0.66 9.17 0.45 5.16e-18 Neuroblastoma; CRC cis rs798554 0.679 rs13230995 chr7:2887284 G/A cg19717773 chr7:2847554 GNA12 -0.4 -5.81 -0.3 1.51e-8 Height; CRC cis rs9916302 0.904 rs10491128 chr17:37551988 G/A cg03013999 chr17:37608204 MED1 -0.45 -6.74 -0.35 7.08e-11 Glomerular filtration rate (creatinine); CRC cis rs7618915 0.501 rs12486554 chr3:52742537 A/T cg10802521 chr3:52805072 NEK4 -0.53 -8.18 -0.41 6.14e-15 Bipolar disorder; CRC cis rs116095464 0.558 rs10057299 chr5:242135 C/T cg22496380 chr5:211416 CCDC127 -0.91 -10.41 -0.5 4.13e-22 Breast cancer; CRC cis rs10450586 0.863 rs7481148 chr11:27298139 A/T cg10370305 chr11:27303972 NA 0.38 6.11 0.32 2.86e-9 Total body bone mineral density; CRC cis rs7584330 0.737 rs7595979 chr2:238364492 G/T cg16989719 chr2:238392110 NA -0.49 -10.09 -0.49 4.83e-21 Prostate cancer; CRC cis rs4730250 0.708 rs4730242 chr7:107057373 G/C cg02696742 chr7:106810147 HBP1 -0.57 -5.9 -0.31 8.9e-9 Osteoarthritis; CRC cis rs4713118 0.662 rs149970 chr6:27980220 C/T cg15786705 chr6:28176104 NA 0.64 8.69 0.43 1.7e-16 Parkinson's disease; CRC trans rs1346081 0.786 rs1425645 chr4:68028175 C/T cg02657892 chr1:62190594 TM2D1 0.52 6.14 0.32 2.39e-9 Intelligence (multi-trait analysis); CRC cis rs6500602 0.701 rs4785968 chr16:4535307 T/A cg06139259 chr16:4526053 HMOX2;NMRAL1 0.52 7.13 0.37 6.53e-12 Schizophrenia; CRC cis rs6693567 0.565 rs4926422 chr1:150315436 T/C cg15654264 chr1:150340011 RPRD2 0.37 5.81 0.31 1.46e-8 Migraine; CRC cis rs2836950 0.565 rs4816617 chr21:40540690 T/C cg11644478 chr21:40555479 PSMG1 -0.51 -7.71 -0.39 1.51e-13 Menarche (age at onset); CRC cis rs12477438 0.798 rs4851179 chr2:99568774 G/T cg14399236 chr2:99771627 LIPT1;TSGA10 -0.71 -9.93 -0.48 1.73e-20 Chronic sinus infection; CRC cis rs3858526 0.642 rs10838783 chr11:5900282 T/G cg13902645 chr11:5959945 NA -0.57 -7.88 -0.4 4.98e-14 DNA methylation (variation); CRC cis rs870825 0.860 rs56180712 chr4:185600223 A/G cg04058563 chr4:185651563 MLF1IP 0.63 6.52 0.34 2.71e-10 Blood protein levels; CRC cis rs9341808 0.718 rs2179842 chr6:80979053 T/C cg08355045 chr6:80787529 NA 0.39 6.43 0.33 4.52e-10 Sitting height ratio; CRC cis rs12477438 0.520 rs36071868 chr2:99737120 G/A cg14399236 chr2:99771627 LIPT1;TSGA10 0.83 14.67 0.63 7.94e-38 Chronic sinus infection; CRC cis rs1448094 0.845 rs17354637 chr12:86347752 A/G cg02569458 chr12:86230093 RASSF9 0.49 8.24 0.41 4.05e-15 Major depressive disorder; CRC cis rs3751196 0.901 rs1057892 chr12:104157234 G/C cg02344784 chr12:104178138 NT5DC3 0.69 6.79 0.35 5.37e-11 Sense of smell; CRC trans rs1005277 0.505 rs7099777 chr10:38183569 A/C cg27523141 chr10:43048294 ZNF37B -0.45 -6.57 -0.34 2.02e-10 Extrinsic epigenetic age acceleration; CRC cis rs9457247 1.000 rs407515 chr6:167407544 G/C cg23791538 chr6:167370224 RNASET2 -0.39 -6.08 -0.32 3.37e-9 Crohn's disease; CRC cis rs9828933 0.766 rs704372 chr3:63867453 T/C cg16258503 chr3:63850278 ATXN7;THOC7 0.72 8.28 0.42 3.07e-15 Type 2 diabetes; CRC cis rs8044995 0.563 rs7190134 chr16:68381516 A/G cg09835421 chr16:68378352 PRMT7 0.78 8.02 0.4 1.83e-14 Schizophrenia; CRC cis rs1865760 0.964 rs6932113 chr6:25913098 C/T cg16482183 chr6:26056742 HIST1H1C 0.54 7.84 0.4 6.42e-14 Height; CRC cis rs7727544 0.582 rs4361509 chr5:131536753 A/G cg18758796 chr5:131593413 PDLIM4 -0.33 -5.63 -0.3 3.93e-8 Blood metabolite levels; CRC cis rs2019137 0.539 rs4849177 chr2:113982584 T/C cg25243455 chr2:114033360 PAX8;LOC440839 -0.29 -6.9 -0.36 2.62e-11 Lymphocyte counts; CRC cis rs7927771 1.000 rs4752797 chr11:47874364 C/T cg18512352 chr11:47633146 NA -0.49 -9.4 -0.46 9.41e-19 Subjective well-being; CRC trans rs853679 0.607 rs34950484 chr6:28278688 G/A cg01620082 chr3:125678407 NA -0.81 -6.31 -0.33 8.98e-10 Depression; CRC cis rs473651 0.935 rs578510 chr2:239343140 C/T cg21699342 chr2:239360505 ASB1 0.58 10.47 0.5 2.42e-22 Multiple system atrophy; CRC cis rs13191362 0.507 rs2849518 chr6:163134248 T/C cg06582575 chr6:163149167 PACRG;PARK2 -0.58 -8.92 -0.44 3.21e-17 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs847577 0.588 rs6946915 chr7:97711340 C/G cg24562669 chr7:97807699 LMTK2 0.75 16.64 0.68 1.47e-45 Breast cancer; CRC cis rs7771547 0.519 rs6917489 chr6:36368169 C/T cg07856975 chr6:36356162 ETV7 0.48 5.9 0.31 9.26e-9 Platelet distribution width; CRC cis rs7647973 0.577 rs6446247 chr3:49102001 A/T cg20833759 chr3:49053208 WDR6;DALRD3 0.76 11.94 0.55 1.55e-27 Menarche (age at onset); CRC cis rs2836974 0.568 rs429955 chr21:40539760 G/A cg06238570 chr21:40685208 BRWD1 0.79 12.82 0.58 8.47e-31 Cognitive function; CRC cis rs6700896 0.931 rs10443261 chr1:66129121 T/C cg04111102 chr1:66153794 NA 0.35 6.1 0.32 3.03e-9 C-reactive protein;Mean corpuscular volume;Mean corpuscular hemoglobin; CRC cis rs10256972 0.552 rs7805591 chr7:1210745 A/G cg09177884 chr7:1199841 ZFAND2A -0.51 -7.5 -0.38 6.05e-13 Longevity;Endometriosis; CRC cis rs12044355 0.858 rs12040259 chr1:231826253 G/A cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX 0.44 6.26 0.33 1.23e-9 Alzheimer's disease; CRC cis rs9649213 0.613 rs2286074 chr7:97952011 G/A cg21770322 chr7:97807741 LMTK2 0.51 8.29 0.42 2.89e-15 Prostate cancer (SNP x SNP interaction); CRC cis rs4319547 0.915 rs1473553 chr12:122985057 G/T cg23029597 chr12:123009494 RSRC2 -0.59 -7.41 -0.38 1.1e-12 Body mass index; CRC cis rs11146838 1 rs11146838 chr10:39149977 A/T cg25951256 chr10:38645740 HSD17B7P2 -0.4 -5.81 -0.31 1.47e-8 Breast cancer; CRC cis rs6502050 0.835 rs66932937 chr17:80116803 G/A cg11859384 chr17:80120422 CCDC57 -0.37 -5.98 -0.31 5.86e-9 Life satisfaction; CRC cis rs561341 0.825 rs2008368 chr17:30347397 T/C cg12193833 chr17:30244370 NA -0.76 -8.95 -0.44 2.68e-17 Hip circumference adjusted for BMI; CRC cis rs10221833 0.602 rs355885 chr2:165633939 G/A cg03182029 chr2:165697222 COBLL1 0.5 5.83 0.31 1.35e-8 Response to statin therapy; CRC cis rs4638749 0.906 rs34974921 chr2:108860253 A/G cg25838818 chr2:108905173 SULT1C2 -0.38 -6.1 -0.32 2.91e-9 Blood pressure; CRC trans rs12702919 0.677 rs12702918 chr7:9550525 C/A cg15597424 chr4:24472487 NA -0.39 -5.97 -0.31 6.29e-9 PR interval in Tripanosoma cruzi seropositivity; CRC cis rs11212617 0.967 rs113995 chr11:108256837 A/T cg12106634 chr11:108092400 ATM;NPAT 0.43 6.47 0.34 3.47e-10 Response to metformin in type 2 diabetes (glycemic); CRC cis rs681343 1.000 rs516246 chr19:49206172 C/T cg01656853 chr19:49199172 FUT2 0.24 5.87 0.31 1.09e-8 Lung adenocarcinoma;Primary sclerosing cholangitis;Childhood ear infection; CRC trans rs12495832 0.778 rs6782620 chr3:147938355 T/G cg10221266 chr7:153579447 NA 0.58 6.22 0.32 1.48e-9 Chin dimples; CRC cis rs12893668 0.543 rs1799796 chr14:104165927 T/C cg24130564 chr14:104152367 KLC1 -0.43 -5.69 -0.3 2.84e-8 Reticulocyte count; CRC cis rs6952808 0.862 rs4721167 chr7:1933224 C/T cg00106254 chr7:1943704 MAD1L1 -0.51 -7.6 -0.39 3.15e-13 Bipolar disorder and schizophrenia; CRC cis rs78456975 0.941 rs6755875 chr2:1557109 T/C cg01028140 chr2:1542097 TPO -0.56 -5.87 -0.31 1.07e-8 Placebo response in major depressive disorder (% change in symptom score); CRC cis rs59104589 0.617 rs12233133 chr2:242256812 G/C cg19488206 chr2:242435732 STK25 0.45 6.26 0.33 1.22e-9 Fibrinogen levels; CRC cis rs10504229 0.815 rs72650877 chr8:58164510 T/C cg05313129 chr8:58192883 C8orf71 -0.5 -6.34 -0.33 7.58e-10 Developmental language disorder (linguistic errors); CRC cis rs2075371 0.863 rs1646635 chr7:134006728 T/C cg20476274 chr7:133979776 SLC35B4 0.75 13.33 0.59 1.03e-32 Mean platelet volume; CRC cis rs10779751 0.959 rs2300091 chr1:11266711 C/T cg08854313 chr1:11322531 MTOR 0.77 12.05 0.55 6.12e-28 Body mass index; CRC cis rs9527 0.590 rs1926037 chr10:104878010 A/C cg04362960 chr10:104952993 NT5C2 0.6 8.31 0.42 2.6e-15 Arsenic metabolism; CRC cis rs6952808 1.000 rs10260585 chr7:1889521 G/A cg22963979 chr7:1858916 MAD1L1 -0.66 -10.13 -0.49 3.7e-21 Bipolar disorder and schizophrenia; CRC cis rs4820539 0.902 rs9612237 chr22:23472954 T/C cg14186256 chr22:23484241 RTDR1 0.9 17.42 0.69 1.29e-48 Bone mineral density; CRC cis rs16867321 0.950 rs4667228 chr2:181498824 T/A cg23363182 chr2:181467187 NA -0.51 -6.65 -0.34 1.21e-10 Obesity; CRC cis rs12586317 0.547 rs10146699 chr14:35483577 G/A cg05294307 chr14:35346193 BAZ1A -0.7 -7.7 -0.39 1.65e-13 Psoriasis; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg07479707 chr1:11396967 NA 0.42 6.56 0.34 2.09e-10 Liver disease severity in Alagille syndrome; CRC cis rs2976388 0.566 rs6998746 chr8:143802456 A/C cg24046110 chr8:143859143 LYNX1 0.45 7.22 0.37 3.72e-12 Urinary tract infection frequency; CRC cis rs7809950 1.000 rs2520249 chr7:107146748 A/G cg23024343 chr7:107201750 COG5 -0.6 -8.61 -0.43 3.06e-16 Coronary artery disease; CRC cis rs7726839 0.794 rs11739663 chr5:594083 A/G cg09021430 chr5:549028 NA -0.62 -8.41 -0.42 1.25e-15 Obesity-related traits; CRC cis rs6674176 0.593 rs6675620 chr1:44417630 C/T cg13606994 chr1:44402422 ARTN -0.33 -5.6 -0.3 4.5e-8 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Cognitive ability; CRC cis rs4332037 0.539 rs4470910 chr7:2071723 C/T cg02421172 chr7:1938701 MAD1L1 0.42 5.63 0.3 3.92e-8 Bipolar disorder; CRC cis rs9368481 0.678 rs62402024 chr6:26923976 T/C cg12292205 chr6:26970375 C6orf41 0.67 10.95 0.52 5.51e-24 Autism spectrum disorder or schizophrenia; CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg06124975 chr6:107810578 SOBP -0.56 -6.9 -0.36 2.74e-11 Diisocyanate-induced asthma; CRC cis rs13108904 0.935 rs4246685 chr4:1279727 T/C cg19318889 chr4:1322082 MAEA 0.4 5.71 0.3 2.57e-8 Obesity-related traits; CRC cis rs7618501 0.633 rs12485600 chr3:50025530 A/G cg24308560 chr3:49941425 MST1R -0.51 -8.29 -0.42 2.86e-15 Intelligence (multi-trait analysis); CRC cis rs3806843 0.608 rs246042 chr5:140330967 G/A cg19875535 chr5:140030758 IK 0.4 6.12 0.32 2.64e-9 Depressive symptoms (multi-trait analysis); CRC trans rs11825064 0.666 rs4245140 chr11:134484487 A/G cg00033773 chr19:12779366 MORG1;C19orf56 0.43 6.05 0.32 3.88e-9 Seasonality; CRC cis rs6585424 0.850 rs61860036 chr10:81934859 C/T cg11900509 chr10:81946545 ANXA11 -0.76 -9.31 -0.46 1.92e-18 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs10982256 0.811 rs10759713 chr9:117254214 G/A cg13636371 chr9:117264095 DFNB31 0.41 7.83 0.4 6.88e-14 Bipolar disorder; CRC trans rs56176327 0.583 rs7613603 chr3:49812866 C/T cg21659725 chr3:3221576 CRBN 0.63 7.06 0.36 1.01e-11 Intelligence (multi-trait analysis); CRC cis rs6076065 0.676 rs6083084 chr20:23335582 A/G cg11657817 chr20:23433608 CST11 -0.42 -6.3 -0.33 9.62e-10 Facial morphology (factor 15, philtrum width); CRC cis rs4713118 0.621 rs4713132 chr6:28034035 A/G cg23161317 chr6:28129485 ZNF389 0.51 6.52 0.34 2.6200000000000003e-10 Parkinson's disease; CRC cis rs10540 1.000 rs12419766 chr11:503710 C/T cg08200582 chr11:442649 ANO9 -0.71 -7.44 -0.38 8.72e-13 Body mass index; CRC cis rs6541297 1.000 rs1997947 chr1:230283764 A/G cg20703242 chr1:230279135 GALNT2 -0.51 -7.97 -0.4 2.6e-14 Coronary artery disease; CRC cis rs7731657 0.537 rs72801791 chr5:130374799 T/C cg08523029 chr5:130500466 HINT1 -0.45 -5.96 -0.31 6.51e-9 Fasting plasma glucose; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg24490039 chr12:120967180 COQ5 0.43 5.97 0.31 6.02e-9 Response to antipsychotic treatment; CRC cis rs13217239 0.646 rs35691005 chr6:26972070 A/G cg12292205 chr6:26970375 C6orf41 0.56 9.32 0.46 1.78e-18 Schizophrenia; CRC cis rs853679 0.517 rs9380062 chr6:28137569 G/A cg23161317 chr6:28129485 ZNF389 0.53 6.43 0.33 4.52e-10 Depression; CRC cis rs11098499 0.954 rs28685688 chr4:120420334 T/C cg09307838 chr4:120376055 NA 0.72 11.05 0.52 2.45e-24 Corneal astigmatism; CRC trans rs2303319 0.504 rs62189042 chr2:162602320 G/T cg11326919 chr17:43324904 LOC100133991 -0.64 -5.97 -0.31 5.99e-9 Cognitive function; CRC trans rs2797160 0.651 rs1269176 chr6:126029682 A/T cg05039488 chr6:79577232 IRAK1BP1 -0.55 -8.5 -0.42 6.75e-16 Endometrial cancer; CRC trans rs1997103 1.000 rs6968966 chr7:55411356 A/G cg20935933 chr6:143382018 AIG1 0.51 6.65 0.34 1.25e-10 QRS interval (sulfonylurea treatment interaction); CRC cis rs9388451 0.772 rs1268064 chr6:126042578 G/A cg05901451 chr6:126070800 HEY2 0.64 10.65 0.51 5.82e-23 Brugada syndrome; CRC cis rs6973256 0.897 rs9656422 chr7:133324665 C/T cg10665199 chr7:133106180 EXOC4 -0.37 -5.78 -0.3 1.7e-8 Intelligence (multi-trait analysis); CRC cis rs2760061 0.626 rs1636192 chr1:228124688 A/G cg18477163 chr1:228402036 OBSCN -0.37 -6.01 -0.31 4.79e-9 Diastolic blood pressure; CRC cis rs847577 0.588 rs12666406 chr7:97790991 G/A cg21770322 chr7:97807741 LMTK2 0.87 19.47 0.73 1.03e-56 Breast cancer; CRC cis rs853679 0.517 rs1853097 chr6:28058635 A/G cg15786705 chr6:28176104 NA 0.76 9.63 0.47 1.68e-19 Depression; CRC cis rs7584330 0.554 rs6736468 chr2:238422228 A/G cg14458575 chr2:238380390 NA 0.41 5.8 0.3 1.53e-8 Prostate cancer; CRC cis rs8060686 0.641 rs7192187 chr16:68132109 T/C cg08314208 chr16:67682810 RLTPR -0.49 -5.88 -0.31 1.01e-8 HDL cholesterol;Metabolic syndrome; CRC cis rs652260 1.000 rs604938 chr19:7903484 A/G cg26014689 chr19:7917955 EVI5L 0.53 8.75 0.43 1.1e-16 Menarche (age at onset); CRC cis rs4481887 1.000 rs4457616 chr1:248492198 A/G cg00666640 chr1:248458726 OR2T12 0.56 9.67 0.47 1.25e-19 Common traits (Other); CRC cis rs7618915 0.571 rs33964154 chr3:52596914 A/G cg05573699 chr3:52720067 GNL3;PBRM1 -0.46 -6.58 -0.34 1.81e-10 Bipolar disorder; CRC cis rs11098499 0.599 rs3864142 chr4:120266191 A/T cg09307838 chr4:120376055 NA 0.62 9.69 0.47 1.07e-19 Corneal astigmatism; CRC cis rs9584850 0.834 rs3803253 chr13:99117149 G/A cg07423050 chr13:99094983 FARP1 0.43 6.0 0.31 5.22e-9 Neuroticism; CRC cis rs2842992 0.830 rs1998365 chr6:160179535 A/T cg19482086 chr6:160211437 TCP1;MRPL18 0.72 9.52 0.46 3.91e-19 Age-related macular degeneration (geographic atrophy); CRC cis rs11098499 0.863 rs3775843 chr4:120427844 T/C cg09307838 chr4:120376055 NA 0.68 10.3 0.49 9.17e-22 Corneal astigmatism; CRC cis rs7811142 1.000 rs67315960 chr7:100015124 A/G cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.16 17.33 0.69 2.96e-48 Platelet count; CRC cis rs13064411 0.735 rs6778800 chr3:113149236 A/G cg18753928 chr3:113234510 CCDC52 -0.51 -7.31 -0.37 1.98e-12 Response to simvastatin treatment (PCSK9 protein level change); CRC cis rs11690935 0.959 rs10207085 chr2:172585885 T/G cg13550731 chr2:172543902 DYNC1I2 -1.1 -18.53 -0.71 5.39e-53 Schizophrenia; CRC cis rs3857536 0.505 rs208459 chr6:66911055 C/T cg07460842 chr6:66804631 NA -0.66 -8.99 -0.44 1.99e-17 Blood trace element (Cu levels); CRC cis rs7937682 0.921 rs12806479 chr11:111443192 G/C cg09085632 chr11:111637200 PPP2R1B 0.98 15.66 0.65 1.12e-41 Primary sclerosing cholangitis; CRC cis rs4689388 0.856 rs1046314 chr4:6303955 A/G cg00701064 chr4:6280414 WFS1 -0.76 -13.09 -0.59 8.7e-32 Type 2 diabetes and other traits;Type 2 diabetes; CRC cis rs1707322 1.000 rs10890377 chr1:46406594 G/A cg06784218 chr1:46089804 CCDC17 0.51 9.07 0.45 1.11e-17 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs11169225 0.724 rs7305290 chr12:50341465 A/G cg04450003 chr12:50355995 AQP5 0.32 5.94 0.31 7.28e-9 Allergic disease (asthma, hay fever or eczema); CRC cis rs2976388 0.565 rs2572905 chr8:143797104 C/T cg04969067 chr8:143858791 LYNX1 0.44 7.54 0.38 4.73e-13 Urinary tract infection frequency; CRC cis rs11148252 0.538 rs9535880 chr13:52706143 G/A cg02158880 chr13:53174818 NA 0.39 5.6 0.3 4.53e-8 Lewy body disease; CRC cis rs826838 0.967 rs1684415 chr12:39130099 T/C cg26384229 chr12:38710491 ALG10B -0.64 -9.67 -0.47 1.21e-19 Heart rate; CRC cis rs1712517 0.838 rs1891293 chr10:105001797 C/T cg05636881 chr10:105038444 INA -0.48 -8.32 -0.42 2.29e-15 Migraine; CRC cis rs73206853 0.698 rs1018134 chr12:111121119 G/A cg12870014 chr12:110450643 ANKRD13A 0.81 9.1 0.45 8.98e-18 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC cis rs7781557 1.000 rs10487281 chr7:102477581 G/C cg18108683 chr7:102477205 FBXL13 -0.55 -7.01 -0.36 1.39e-11 Colorectal adenoma (advanced); CRC cis rs7618915 0.501 rs2079929 chr3:52765646 C/T cg15147215 chr3:52552868 STAB1 -0.63 -10.74 -0.51 2.95e-23 Bipolar disorder; CRC cis rs9611565 0.694 rs202665 chr22:41814401 A/G cg03806693 chr22:41940476 POLR3H 1.03 12.95 0.58 2.89e-31 Vitiligo; CRC cis rs4555082 0.957 rs2975216 chr14:105713134 T/C cg10792982 chr14:105748885 BRF1 0.32 5.6 0.3 4.5e-8 Mean platelet volume;Platelet distribution width; CRC cis rs1552244 0.938 rs34750074 chr3:10091740 G/A cg02579736 chr3:10068473 FANCD2;CIDECP 1.03 13.94 0.61 4.9e-35 Alzheimer's disease; CRC cis rs1552244 0.882 rs13064570 chr3:9997545 G/C cg16606324 chr3:10149918 C3orf24 0.61 7.95 0.4 2.97e-14 Alzheimer's disease; CRC cis rs10927875 0.631 rs28579893 chr1:16347534 A/G cg22431228 chr1:16359049 CLCNKA -0.45 -8.01 -0.4 2.04e-14 Dilated cardiomyopathy; CRC cis rs11622475 1.000 rs11622475 chr14:104509076 C/T cg12183467 chr14:104352244 NA -0.5 -6.04 -0.32 4.28e-9 Bipolar disorder; CRC cis rs611744 0.647 rs2597658 chr8:109256014 C/T cg18478394 chr8:109455254 TTC35 0.38 5.82 0.31 1.43e-8 Dupuytren's disease; CRC cis rs79349575 0.729 rs62075824 chr17:46986679 A/G cg22482690 chr17:47019901 SNF8 0.49 8.2 0.41 5.58e-15 Type 2 diabetes; CRC trans rs3942852 0.545 rs7395231 chr11:48091689 T/C cg03929089 chr4:120376271 NA -0.6 -8.31 -0.42 2.59e-15 Acute lymphoblastic leukemia (childhood); CRC cis rs13256369 1.000 rs4840352 chr8:8573508 A/G cg00074818 chr8:8560427 CLDN23 0.4 7.24 0.37 3.13e-12 Obesity-related traits; CRC trans rs2553218 0.690 rs8032415 chr15:54851945 A/G cg17737141 chr1:173793901 CENPL;DARS2 0.47 6.16 0.32 2.14e-9 Immune response to smallpox vaccine (IL-6); CRC cis rs1801251 1.000 rs7606090 chr2:233606740 T/C cg25237894 chr2:233734115 C2orf82 0.5 8.19 0.41 5.92e-15 Coronary artery disease; CRC cis rs8141797 0.901 rs6004051 chr22:24462072 A/C cg20894457 chr22:24584366 SUSD2 -0.6 -5.85 -0.31 1.18e-8 Amyotrophic lateral sclerosis;Coronary artery disease; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg00012762 chr17:72744649 SLC9A3R1 0.46 7.64 0.39 2.35e-13 Liver disease severity in Alagille syndrome; CRC cis rs1153858 1.000 rs72623915 chr15:45647433 C/T cg14582100 chr15:45693742 SPATA5L1 0.28 5.91 0.31 8.44e-9 Homoarginine levels; CRC cis rs9916302 0.904 rs7208274 chr17:37513796 C/T cg07936489 chr17:37558343 FBXL20 0.84 13.09 0.59 8.21e-32 Glomerular filtration rate (creatinine); CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg15254786 chr2:207630414 MDH1B;FASTKD2 -0.51 -6.23 -0.32 1.4e-9 Diisocyanate-induced asthma; CRC cis rs9916302 0.904 rs7208274 chr17:37513796 C/T cg00129232 chr17:37814104 STARD3 0.54 7.99 0.4 2.24e-14 Glomerular filtration rate (creatinine); CRC cis rs7552404 0.731 rs1770887 chr1:76401812 A/G cg03433033 chr1:76189801 ACADM -0.61 -7.71 -0.39 1.53e-13 Blood metabolite levels;Acylcarnitine levels; CRC cis rs950027 0.787 rs2433616 chr15:45728599 A/G cg10760299 chr15:45669010 GATM 0.35 5.62 0.3 4.02e-8 Response to fenofibrate (adiponectin levels); CRC cis rs6460942 0.908 rs6979046 chr7:12232744 A/G cg06484146 chr7:12443880 VWDE -0.58 -6.05 -0.32 4.03e-9 Coronary artery disease; CRC cis rs1153858 1.000 rs16952714 chr15:45650358 G/A cg21132104 chr15:45694354 SPATA5L1 0.58 8.55 0.43 4.8e-16 Homoarginine levels; CRC cis rs4925386 0.765 rs6142737 chr20:60919800 C/G cg06026331 chr20:60912101 LAMA5 0.39 5.75 0.3 2.08e-8 Colorectal cancer;Colorectal cancer (SNP x SNP interaction); CRC cis rs6735179 0.798 rs6737190 chr2:1779036 C/A cg19300414 chr2:1746591 PXDN 0.39 5.69 0.3 2.81e-8 Response to antipsychotic treatment; CRC cis rs9430161 0.579 rs7542158 chr1:11040193 G/A cg27631724 chr1:11040367 C1orf127 0.36 7.3 0.37 2.15e-12 Ewing sarcoma; CRC cis rs1799949 1.000 rs35330014 chr17:41212547 C/T cg25072359 chr17:41440525 NA 0.47 7.16 0.37 5.18e-12 Menopause (age at onset); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg23313650 chr7:123389169 WASL 0.4 6.45 0.34 3.89e-10 Liver disease severity in Alagille syndrome; CRC cis rs9311676 0.656 rs55913214 chr3:58388026 A/G cg06643156 chr3:58380774 PXK 0.41 6.33 0.33 7.82e-10 Systemic lupus erythematosus; CRC cis rs7568458 0.684 rs67988001 chr2:85787123 C/T cg02493740 chr2:85810744 VAMP5 -0.55 -8.26 -0.41 3.69e-15 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); CRC cis rs58688157 0.660 rs12797496 chr11:583767 C/T cg01842473 chr11:617407 IRF7;MUPCDH -0.55 -6.34 -0.33 7.41e-10 Systemic lupus erythematosus; CRC cis rs1448094 0.617 rs4842569 chr12:86468609 T/G cg02569458 chr12:86230093 RASSF9 -0.42 -7.14 -0.37 6.06e-12 Major depressive disorder; CRC cis rs1577917 0.958 rs2121594 chr6:86576854 C/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.53 -6.61 -0.34 1.51e-10 Response to antipsychotic treatment; CRC cis rs6570726 0.764 rs9403726 chr6:145901686 G/T cg23711669 chr6:146136114 FBXO30 0.65 10.66 0.51 5.31e-23 Lobe attachment (rater-scored or self-reported); CRC cis rs10751667 0.580 rs10751664 chr11:927077 T/G cg23136738 chr11:925521 AP2A2 -0.41 -6.8 -0.35 4.92e-11 Alzheimer's disease (late onset); CRC cis rs2404602 0.716 rs1588961 chr15:76752698 A/G cg03037974 chr15:76606532 NA 0.73 13.13 0.59 5.83e-32 Blood metabolite levels; CRC cis rs1018836 0.663 rs4735190 chr8:91509601 A/G cg16814680 chr8:91681699 NA -0.69 -10.17 -0.49 2.56e-21 Ejection fraction in Tripanosoma cruzi seropositivity; CRC cis rs4713118 0.513 rs149972 chr6:27983227 C/T cg21251018 chr6:28226885 NKAPL 0.48 7.42 0.38 9.78e-13 Parkinson's disease; CRC trans rs1005277 0.579 rs2505237 chr10:38438898 T/G cg23533926 chr12:111358616 MYL2 -0.51 -7.67 -0.39 1.95e-13 Extrinsic epigenetic age acceleration; CRC cis rs12188164 0.515 rs17562461 chr5:411361 C/T cg26850624 chr5:429559 AHRR -0.68 -10.74 -0.51 2.97e-23 Cystic fibrosis severity; CRC cis rs1552244 0.882 rs13084194 chr3:10031492 T/A cg08888203 chr3:10149979 C3orf24 0.59 7.3 0.37 2.17e-12 Alzheimer's disease; CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg16189954 chr22:29138267 HSCB;CHEK2 -0.48 -5.99 -0.31 5.5e-9 Diisocyanate-induced asthma; CRC cis rs6502050 0.835 rs55679819 chr17:80105450 C/T cg11859384 chr17:80120422 CCDC57 -0.36 -5.72 -0.3 2.36e-8 Life satisfaction; CRC trans rs6545977 0.531 rs2539982 chr2:63111004 G/A cg05376469 chr2:102649931 NA -0.36 -6.08 -0.32 3.25e-9 Prostate cancer; CRC cis rs6088580 0.601 rs6059827 chr20:33016358 C/T cg08999081 chr20:33150536 PIGU 0.61 11.55 0.54 3.94e-26 Glomerular filtration rate (creatinine); CRC cis rs6540556 0.723 rs11487867 chr1:209892070 G/T cg05527609 chr1:210001259 C1orf107 -0.62 -5.98 -0.31 5.89e-9 Red blood cell count; CRC cis rs7209700 0.547 rs61131650 chr17:45344327 G/A cg17185639 chr17:45330862 ITGB3 0.39 6.11 0.32 2.76e-9 IgG glycosylation; CRC cis rs9486719 0.857 rs3798293 chr6:97033370 A/G cg06623918 chr6:96969491 KIAA0776 -0.83 -10.84 -0.51 1.27e-23 Migraine;Coronary artery disease; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg00251250 chr1:234746546 IRF2BP2 0.37 5.96 0.31 6.53e-9 Liver disease severity in Alagille syndrome; CRC cis rs938554 0.571 rs7696092 chr4:10025320 C/A cg00071950 chr4:10020882 SLC2A9 0.55 8.06 0.41 1.43e-14 Blood metabolite levels; CRC cis rs7833986 0.534 rs2458083 chr8:56898785 G/A cg23139584 chr8:56987506 RPS20;SNORD54 0.79 11.35 0.53 2e-25 Height; CRC cis rs282587 0.569 rs403530 chr13:113396380 G/A cg04656015 chr13:113407548 ATP11A 0.63 7.8 0.4 8.04e-14 Glycated hemoglobin levels; CRC cis rs12282928 0.959 rs2170663 chr11:48319806 A/T cg20307385 chr11:47447363 PSMC3 -0.46 -5.64 -0.3 3.66e-8 Migraine - clinic-based; CRC cis rs1451375 0.617 rs17733244 chr7:50575495 T/C cg14593290 chr7:50529359 DDC 0.64 7.8 0.4 8.1e-14 Malaria; CRC cis rs734999 0.588 rs78506337 chr1:2537095 G/A cg18854424 chr1:2615690 NA 0.46 8.99 0.44 1.95e-17 Ulcerative colitis; CRC cis rs2084637 0.931 rs35916509 chr11:122397509 T/A cg21585512 chr11:122030076 LOC399959 -0.4 -7.39 -0.38 1.22e-12 Stroke; CRC trans rs800082 0.516 rs12486830 chr3:144228339 A/T cg24215973 chr2:240111563 HDAC4 0.46 6.38 0.33 5.92e-10 Smoking behavior; CRC trans rs11039798 1.000 rs10838918 chr11:48507449 A/G cg03929089 chr4:120376271 NA 0.62 5.98 0.31 5.79e-9 Axial length; CRC cis rs736408 0.609 rs2268025 chr3:52795224 A/T cg18099408 chr3:52552593 STAB1 -0.45 -7.24 -0.37 3.11e-12 Bipolar disorder; CRC cis rs7584330 0.666 rs72620819 chr2:238354982 C/T cg14458575 chr2:238380390 NA 0.89 15.86 0.66 1.84e-42 Prostate cancer; CRC cis rs1577917 1.000 rs1911552 chr6:86638024 T/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.51 -6.86 -0.35 3.34e-11 Response to antipsychotic treatment; CRC cis rs992157 0.698 rs6746089 chr2:219170377 A/G cg04880052 chr2:219191631 PNKD 0.42 6.77 0.35 6.09e-11 Colorectal cancer; CRC cis rs1555322 0.530 rs7004 chr20:33866753 G/C cg08210727 chr20:33865349 NA 0.49 6.17 0.32 1.96e-9 Attention deficit hyperactivity disorder; CRC cis rs9311474 1.000 rs2276834 chr3:52325759 A/G cg15147215 chr3:52552868 STAB1 -0.66 -11.52 -0.54 4.85e-26 Electroencephalogram traits; CRC cis rs9303401 0.659 rs8074016 chr17:56840587 A/G cg02118635 chr17:56770003 RAD51C;TEX14 0.75 9.3 0.46 2.03e-18 Cognitive test performance; CRC cis rs10540 1.000 rs12419716 chr11:503385 C/G cg15790184 chr11:494944 RNH1 0.6 6.17 0.32 1.95e-9 Body mass index; CRC trans rs2303319 0.504 rs16846050 chr2:162563553 A/G cg18122310 chr12:50236657 BCDIN3D 0.75 6.17 0.32 2.03e-9 Cognitive function; CRC cis rs1153858 1.000 rs12593230 chr15:45646968 A/T cg10760299 chr15:45669010 GATM 0.49 7.72 0.39 1.43e-13 Homoarginine levels; CRC cis rs10463316 0.894 rs6579864 chr5:150762181 G/A cg03212797 chr5:150827313 SLC36A1 -0.5 -7.78 -0.39 9.41e-14 Metabolite levels (Pyroglutamine); CRC cis rs4713118 0.662 rs4713120 chr6:27721835 C/A cg02683197 chr6:28174875 NA 0.55 7.84 0.4 6.25e-14 Parkinson's disease; CRC cis rs7107174 1.000 rs10793295 chr11:77996521 C/G cg02023728 chr11:77925099 USP35 -0.47 -8.22 -0.41 4.88e-15 Testicular germ cell tumor; CRC cis rs2730245 0.527 rs62476462 chr7:158686619 A/G cg24397884 chr7:158709396 WDR60 0.92 11.35 0.53 2.01e-25 Height; CRC cis rs736408 0.609 rs2336545 chr3:52787603 C/T cg10802521 chr3:52805072 NEK4 0.56 8.65 0.43 2.28e-16 Bipolar disorder; CRC cis rs4132509 0.744 rs58594024 chr1:243862702 C/A cg21452805 chr1:244014465 NA 0.6 7.58 0.39 3.47e-13 RR interval (heart rate); CRC cis rs3857536 0.776 rs2040593 chr6:66944076 G/A cg07460842 chr6:66804631 NA -0.42 -5.72 -0.3 2.44e-8 Blood trace element (Cu levels); CRC cis rs6500395 0.926 rs11076572 chr16:48623621 T/G cg04672837 chr16:48644449 N4BP1 0.42 6.04 0.32 4.1e-9 Response to tocilizumab in rheumatoid arthritis; CRC cis rs6952808 0.929 rs12667688 chr7:1931030 C/T cg20295408 chr7:1910781 MAD1L1 -0.44 -6.04 -0.32 4.26e-9 Bipolar disorder and schizophrenia; CRC cis rs2290159 0.752 rs73130368 chr3:12667374 C/T cg23032965 chr3:12705835 RAF1 0.5 6.38 0.33 5.92e-10 Cholesterol, total; CRC cis rs453301 0.653 rs11784393 chr8:8903134 C/T cg06636001 chr8:8085503 FLJ10661 0.49 7.14 0.37 5.92e-12 Joint mobility (Beighton score); CRC cis rs4713118 0.869 rs9461401 chr6:27703291 G/A cg15786705 chr6:28176104 NA 0.54 7.62 0.39 2.72e-13 Parkinson's disease; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg25994096 chr11:61348278 SYT7 -0.41 -6.33 -0.33 8.08e-10 Myopia (pathological); CRC cis rs10782582 0.593 rs6675076 chr1:76118503 A/C cg10523679 chr1:76189770 ACADM -0.42 -5.94 -0.31 7.41e-9 Daytime sleep phenotypes; CRC cis rs9928842 0.882 rs8048956 chr16:75254966 C/G cg08657710 chr16:75258780 CTRB1 0.46 5.68 0.3 3.01e-8 Alcoholic chronic pancreatitis; CRC trans rs7726839 0.540 rs72703083 chr5:595365 C/T cg25482853 chr8:67687455 SGK3 1.09 12.84 0.58 7.36e-31 Obesity-related traits; CRC cis rs2836950 0.545 rs2836952 chr21:40616651 G/C cg17971929 chr21:40555470 PSMG1 -0.58 -8.46 -0.42 8.75e-16 Menarche (age at onset); CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg12230010 chr10:72163718 EIF4EBP2 0.52 6.91 0.36 2.56e-11 Thyroid stimulating hormone; CRC cis rs4713118 0.955 rs9393848 chr6:27688369 C/T cg25164649 chr6:28176230 NA 0.56 7.66 0.39 2.12e-13 Parkinson's disease; CRC cis rs2204008 0.811 rs2139752 chr12:38370398 C/T cg13010199 chr12:38710504 ALG10B 0.47 6.3 0.33 9.76e-10 Bladder cancer; CRC cis rs11971779 0.590 rs4732374 chr7:139091453 G/C cg07862535 chr7:139043722 LUC7L2 0.57 7.35 0.38 1.61e-12 Diisocyanate-induced asthma; CRC cis rs7666738 0.830 rs10049627 chr4:99025272 A/C cg17366294 chr4:99064904 C4orf37 0.44 7.48 0.38 6.96e-13 Colonoscopy-negative controls vs population controls; CRC cis rs9768139 0.733 rs13225172 chr7:158120334 G/A cg24154853 chr7:158122151 PTPRN2 0.62 10.22 0.49 1.77e-21 Calcium levels; CRC cis rs9682041 0.561 rs7643214 chr3:170144281 C/T cg11886554 chr3:170076028 SKIL 0.68 7.57 0.39 3.81e-13 Glomerular filtration rate in non diabetics (creatinine);Glomerular filtration rate (creatinine); CRC cis rs2952156 0.959 rs1565922 chr17:37831035 A/G cg11212589 chr17:38028394 ZPBP2 0.33 5.67 0.3 3.19e-8 Asthma; CRC cis rs6502050 0.805 rs9915071 chr17:80119138 T/C cg02741985 chr17:80059408 CCDC57 0.43 7.15 0.37 5.59e-12 Life satisfaction; CRC trans rs4824093 0.610 rs7410773 chr22:50313727 A/G cg09872104 chr7:134855509 C7orf49 -0.87 -8.4 -0.42 1.33e-15 Amyotrophic lateral sclerosis (sporadic); CRC cis rs853679 0.546 rs493161 chr6:27850714 A/T cg15845792 chr6:28175446 NA 0.71 5.88 0.31 1e-8 Depression; CRC cis rs17818399 0.708 rs1531133 chr2:46843631 A/G cg26688816 chr2:46740690 ATP6V1E2 -0.47 -7.07 -0.36 9.07e-12 Height; CRC cis rs738322 0.934 rs133016 chr22:38572582 C/T cg17652424 chr22:38574118 PLA2G6 -0.22 -6.86 -0.35 3.41e-11 Cutaneous nevi; CRC cis rs2404602 0.622 rs11637296 chr15:77207885 C/A cg23625390 chr15:77176239 SCAPER -0.86 -12.54 -0.57 9.81e-30 Blood metabolite levels; CRC cis rs7772486 0.534 rs34541797 chr6:146205304 A/G cg05347473 chr6:146136440 FBXO30 0.49 7.04 0.36 1.12e-11 Lobe attachment (rater-scored or self-reported); CRC trans rs916888 0.821 rs199507 chr17:44858855 A/G cg07870213 chr5:140052090 DND1 -0.85 -10.09 -0.49 4.88e-21 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs8078723 0.966 rs57968500 chr17:38145828 A/G cg17467752 chr17:38218738 THRA 0.74 12.02 0.55 7.59e-28 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); CRC cis rs673253 0.686 rs2819333 chr1:44014573 A/T cg10881128 chr1:44031826 PTPRF 0.21 6.43 0.33 4.6e-10 Intelligence (multi-trait analysis); CRC cis rs12188164 0.515 rs11744936 chr5:412112 C/T cg00976097 chr5:421733 AHRR -0.42 -5.66 -0.3 3.32e-8 Cystic fibrosis severity; CRC trans rs7301826 0.627 rs7315707 chr12:131272819 A/G cg04026000 chr5:79628372 NA -0.48 -6.07 -0.32 3.43e-9 Plasma plasminogen activator levels; CRC cis rs1448094 0.809 rs11117103 chr12:86314431 C/T cg18827107 chr12:86230957 RASSF9 -0.42 -6.81 -0.35 4.62e-11 Major depressive disorder; CRC cis rs7809950 0.798 rs10281535 chr7:107229618 T/G cg23024343 chr7:107201750 COG5 0.59 8.64 0.43 2.43e-16 Coronary artery disease; CRC cis rs7666738 0.791 rs13111960 chr4:98976851 C/T cg17366294 chr4:99064904 C4orf37 0.44 7.32 0.37 1.94e-12 Colonoscopy-negative controls vs population controls; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg00476814 chr22:19974536 ARVCF 0.38 6.33 0.33 7.84e-10 Liver disease severity in Alagille syndrome; CRC trans rs7395662 1.000 rs12366208 chr11:48563128 T/A cg21153622 chr11:89784906 NA -0.47 -7.58 -0.39 3.59e-13 HDL cholesterol; CRC cis rs6087990 0.735 rs4911260 chr20:31376490 T/C cg13636640 chr20:31349939 DNMT3B 0.75 13.65 0.6 6.45e-34 Ulcerative colitis; CRC cis rs736801 0.808 rs2706403 chr5:131799012 A/G cg21138405 chr5:131827807 IRF1 0.35 6.03 0.32 4.33e-9 Breast cancer;Mosquito bite size; CRC cis rs12142240 0.698 rs45517837 chr1:46859225 A/G cg00530320 chr1:46809349 NSUN4 0.59 8.07 0.41 1.35e-14 Menopause (age at onset); CRC cis rs939658 0.776 rs869672 chr15:79430860 G/A cg17916960 chr15:79447300 NA -0.45 -7.31 -0.37 2.08e-12 Refractive error; CRC cis rs910187 0.605 rs6018324 chr20:45810181 G/C cg27589058 chr20:45804311 EYA2 -0.41 -7.74 -0.39 1.24e-13 Migraine; CRC trans rs7618501 0.722 rs9853458 chr3:49783211 A/C cg21665057 chr3:196295764 WDR53;FBXO45 -0.86 -15.78 -0.66 3.79e-42 Intelligence (multi-trait analysis); CRC cis rs9649213 0.574 rs7790229 chr7:97919338 G/A cg24562669 chr7:97807699 LMTK2 0.43 7.14 0.37 5.83e-12 Prostate cancer (SNP x SNP interaction); CRC cis rs9443645 0.810 rs10943613 chr6:79745107 C/T cg09184832 chr6:79620586 NA -0.49 -8.82 -0.44 6.68e-17 Intelligence (multi-trait analysis); CRC cis rs9611565 0.512 rs139561 chr22:42195410 C/T cg06634786 chr22:41940651 POLR3H 0.67 7.49 0.38 6.22e-13 Vitiligo; CRC cis rs4713118 0.513 rs149975 chr6:27986340 G/A cg21251018 chr6:28226885 NKAPL 0.47 7.31 0.37 2.08e-12 Parkinson's disease; CRC cis rs3768617 0.510 rs1413387 chr1:183096774 G/A ch.1.3577855R chr1:183094577 LAMC1 0.85 14.6 0.63 1.48e-37 Fuchs's corneal dystrophy; CRC cis rs995000 0.931 rs7539035 chr1:63106767 G/T cg19896129 chr1:63156450 NA 0.41 6.47 0.34 3.52e-10 Triglyceride levels; CRC cis rs6502050 0.871 rs6502055 chr17:80070868 G/T cg02741985 chr17:80059408 CCDC57 -0.45 -7.11 -0.36 7.45e-12 Life satisfaction; CRC cis rs713477 0.654 rs998871 chr14:55918302 G/A cg13175173 chr14:55914753 NA -0.44 -7.61 -0.39 2.96e-13 Pediatric bone mineral content (femoral neck); CRC cis rs9583531 0.574 rs61971615 chr13:111353111 C/T cg24331049 chr13:111365604 ING1 -0.61 -8.42 -0.42 1.21e-15 Coronary artery disease; CRC cis rs55675132 0.510 rs55953277 chr1:115270907 T/A cg12756093 chr1:115239321 AMPD1 0.52 6.14 0.32 2.33e-9 Schizophrenia; CRC trans rs11581859 0.950 rs72730324 chr1:99388561 A/C cg12183875 chr3:169587454 LRRC31 0.29 6.42 0.33 4.74e-10 Response to cognitive-behavioural therapy in anxiety disorder; CRC trans rs4586057 0.812 rs4282910 chr10:92631244 C/T cg26894278 chr13:21016241 CRYL1 0.39 6.57 0.34 1.93e-10 Economic and political preferences (time); CRC cis rs12497850 0.931 rs11705888 chr3:48817289 T/C cg20833759 chr3:49053208 WDR6;DALRD3 0.5 8.48 0.42 7.52e-16 Parkinson's disease; CRC cis rs3936840 0.686 rs2896439 chr14:102806291 A/G cg18135206 chr14:102964638 TECPR2 0.41 5.66 0.3 3.22e-8 Plateletcrit; CRC cis rs13108904 0.875 rs1732099 chr4:1282696 T/C cg19318889 chr4:1322082 MAEA -0.42 -6.35 -0.33 7.29e-10 Obesity-related traits; CRC cis rs769267 0.831 rs2872878 chr19:19480521 G/C cg03709012 chr19:19516395 GATAD2A -0.7 -10.67 -0.51 4.99e-23 Tonsillectomy; CRC cis rs6815814 0.950 rs5743571 chr4:38805489 C/T cg06935464 chr4:38784597 TLR10 0.57 5.97 0.31 6.19e-9 Breast cancer; CRC cis rs904251 0.828 rs1757178 chr6:37486310 C/T cg01843034 chr6:37503916 NA 0.46 8.6 0.43 3.21e-16 Cognitive performance; CRC cis rs672059 1.000 rs672059 chr1:183162539 G/A ch.1.3577855R chr1:183094577 LAMC1 0.49 7.1 0.36 7.63e-12 Hypertriglyceridemia; CRC cis rs3736485 0.966 rs4775965 chr15:51908251 A/G cg08986416 chr15:51914746 DMXL2 -0.46 -6.53 -0.34 2.57e-10 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs2839186 0.596 rs4819217 chr21:47644092 G/T cg11766577 chr21:47581405 C21orf56 -0.37 -5.69 -0.3 2.85e-8 Testicular germ cell tumor; CRC cis rs72634258 0.945 rs12730860 chr1:8132462 T/C cg26816564 chr1:7831052 VAMP3 0.56 6.08 0.32 3.26e-9 Inflammatory bowel disease; CRC cis rs2580764 0.566 rs2920900 chr2:55280083 T/C cg09592903 chr2:55203963 RTN4 0.65 10.49 0.5 2.14e-22 Mean platelet volume; CRC trans rs6550704 0.687 rs9865314 chr3:22634337 A/G cg02208506 chr17:4634804 MED11 -0.42 -6.13 -0.32 2.53e-9 Daytime sleep phenotypes; CRC cis rs9549260 0.755 rs4943798 chr13:41202948 T/C cg21288729 chr13:41239152 FOXO1 0.48 7.59 0.39 3.25e-13 Red blood cell count; CRC cis rs7615952 0.599 rs6779141 chr3:125709995 A/T cg02772935 chr3:125709198 NA -0.51 -5.99 -0.31 5.46e-9 Blood pressure (smoking interaction); CRC cis rs3750965 0.959 rs2253658 chr11:68856804 C/G cg06818126 chr11:68850279 TPCN2 -0.47 -6.52 -0.34 2.67e-10 Hair color; CRC cis rs4629710 0.592 rs13200165 chr6:131549167 G/C cg12606694 chr6:131520996 AKAP7 0.57 8.47 0.42 8.23e-16 Multiple myeloma (IgH translocation); CRC cis rs6952808 0.594 rs3778969 chr7:2139990 A/G cg21782813 chr7:2030301 MAD1L1 -0.54 -9.53 -0.47 3.48e-19 Bipolar disorder and schizophrenia; CRC cis rs755249 0.567 rs72661965 chr1:39846590 A/C cg18385671 chr1:39797026 MACF1 -0.4 -5.78 -0.3 1.74e-8 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs12760731 0.920 rs4132869 chr1:178476501 A/T cg00404053 chr1:178313656 RASAL2 0.86 8.35 0.42 1.88e-15 Obesity-related traits; CRC cis rs853679 0.517 rs3173443 chr6:28137027 T/G cg25164649 chr6:28176230 NA 0.78 9.66 0.47 1.33e-19 Depression; CRC cis rs780096 0.526 rs3845686 chr2:27655447 T/G cg24768116 chr2:27665128 KRTCAP3 -0.37 -7.95 -0.4 2.99e-14 Total body bone mineral density; CRC cis rs12505749 0.542 rs17086794 chr4:57334752 C/T cg06922635 chr4:57371607 ARL9 -0.52 -5.63 -0.3 3.83e-8 Airflow obstruction; CRC cis rs270601 0.955 rs273911 chr5:131661526 C/G cg27615366 chr5:131592974 PDLIM4 0.33 5.75 0.3 2e-8 Acylcarnitine levels; CRC cis rs6088590 1.000 rs6058111 chr20:33310999 T/C cg24642439 chr20:33292090 TP53INP2 0.59 10.78 0.51 2.09e-23 Coronary artery disease; CRC cis rs911555 0.692 rs7145753 chr14:103866100 G/A cg12935359 chr14:103987150 CKB 0.55 8.89 0.44 4.03e-17 Intelligence (multi-trait analysis); CRC cis rs4713118 0.513 rs149954 chr6:28035246 G/A cg15845792 chr6:28175446 NA 0.77 11.47 0.53 7.32e-26 Parkinson's disease; CRC cis rs1552244 1.000 rs6791810 chr3:10124444 A/G cg10729496 chr3:10149963 C3orf24 -0.54 -7.21 -0.37 3.96e-12 Alzheimer's disease; CRC cis rs929354 0.772 rs3802117 chr7:156987000 C/T cg05182265 chr7:156933206 UBE3C -0.76 -14.52 -0.62 3.01e-37 Body mass index; CRC cis rs10504229 1.000 rs1390411 chr8:58194146 C/A cg24829409 chr8:58192753 C8orf71 -0.6 -10.07 -0.49 5.72e-21 Developmental language disorder (linguistic errors); CRC cis rs889312 0.500 rs33323 chr5:56175566 C/G cg18230493 chr5:56204884 C5orf35 -0.4 -5.9 -0.31 9.16e-9 Breast cancer;Breast cancer (early onset); CRC cis rs8180040 0.654 rs62246451 chr3:47211632 C/T cg02527881 chr3:46936655 PTH1R 0.35 6.09 0.32 3.07e-9 Colorectal cancer; CRC cis rs4713118 0.662 rs9468275 chr6:28026136 G/T cg23161317 chr6:28129485 ZNF389 0.44 5.71 0.3 2.49e-8 Parkinson's disease; CRC trans rs7395662 0.504 rs1814158 chr11:48437937 C/T cg15704280 chr7:45808275 SEPT13 -0.47 -6.73 -0.35 7.35e-11 HDL cholesterol; CRC cis rs531930 0.959 rs483052 chr6:124728270 A/C cg05308643 chr6:124982296 NKAIN2 -0.45 -5.9 -0.31 8.91e-9 Celiac disease; CRC cis rs3858526 0.628 rs1840177 chr11:5944627 T/G cg13902645 chr11:5959945 NA 0.73 12.13 0.56 3.09e-28 DNA methylation (variation); CRC cis rs9733 0.596 rs7549795 chr1:150656873 G/A cg10589385 chr1:150898437 SETDB1 0.27 5.74 0.3 2.13e-8 Tonsillectomy; CRC cis rs7089973 0.604 rs11196932 chr10:116584386 C/T cg23260525 chr10:116636907 FAM160B1 0.35 8.07 0.41 1.34e-14 Bipolar disorder or attention deficit hyperactivity disorder; CRC cis rs6840360 0.615 rs12647462 chr4:152607278 C/T cg09659197 chr4:152720779 NA 0.4 7.88 0.4 4.97e-14 Intelligence (multi-trait analysis); CRC cis rs7580658 0.963 rs12463451 chr2:128053883 C/T cg09760422 chr2:128146352 NA -0.37 -7.22 -0.37 3.74e-12 Protein C levels; CRC cis rs10911363 0.509 rs10911339 chr1:183442097 C/T cg09173681 chr1:183549694 NCF2 0.76 10.42 0.5 3.71e-22 Systemic lupus erythematosus; CRC cis rs546131 0.963 rs539044 chr11:34841542 G/T cg24088639 chr11:34937564 PDHX;APIP -0.48 -6.73 -0.35 7.75e-11 Lung disease severity in cystic fibrosis; CRC cis rs60871478 0.945 rs4719279 chr7:813618 T/C cg13844804 chr7:814759 HEATR2 0.63 8.15 0.41 7.48e-15 Cerebrospinal P-tau181p levels; CRC cis rs9309473 0.607 rs7573719 chr2:73582986 G/A cg20560298 chr2:73613845 ALMS1 -0.47 -6.45 -0.34 4.01e-10 Metabolite levels; CRC cis rs394563 0.534 rs388335 chr6:149791986 T/C cg11245181 chr6:149772854 ZC3H12D -0.52 -7.82 -0.4 7.14e-14 Dupuytren's disease; CRC cis rs270601 0.661 rs10036208 chr5:131571323 T/C cg18758796 chr5:131593413 PDLIM4 0.53 9.12 0.45 7.61e-18 Acylcarnitine levels; CRC cis rs514406 0.861 rs551435 chr1:53260537 G/T cg25767906 chr1:53392781 SCP2 0.47 7.48 0.38 6.61e-13 Monocyte count; CRC cis rs1545257 0.505 rs67786999 chr2:24637160 T/G cg06627628 chr2:24431161 ITSN2 -0.48 -7.09 -0.36 8.44e-12 Sjögren's syndrome; CRC cis rs951366 0.764 rs708724 chr1:205743663 A/C cg24503407 chr1:205819492 PM20D1 0.83 13.04 0.58 1.3e-31 Menarche (age at onset); CRC cis rs4713118 0.614 rs9380007 chr6:27660508 T/C cg21251018 chr6:28226885 NKAPL 0.42 6.73 0.35 7.45e-11 Parkinson's disease; CRC cis rs3733585 0.638 rs17185835 chr4:9958180 T/G cg11266682 chr4:10021025 SLC2A9 -0.47 -9.63 -0.47 1.69e-19 Cleft plate (environmental tobacco smoke interaction); CRC cis rs11711311 0.747 rs7638449 chr3:113343646 T/C cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.54 -7.16 -0.37 5.34e-12 IgG glycosylation; CRC cis rs763121 0.853 rs8142098 chr22:39058757 T/G cg06544989 chr22:39130855 UNC84B 0.45 6.86 0.35 3.33e-11 Menopause (age at onset); CRC trans rs7937682 0.889 rs559482 chr11:111497902 G/A cg18187862 chr3:45730750 SACM1L 0.47 6.69 0.35 9.58e-11 Primary sclerosing cholangitis; CRC cis rs1223397 0.651 rs202018 chr6:13301502 G/A cg07912922 chr6:13274314 PHACTR1 0.37 5.71 0.3 2.53e-8 Blood pressure; CRC cis rs3087591 0.960 rs2905878 chr17:29511199 T/C cg24425628 chr17:29625626 OMG;NF1 0.85 16.13 0.66 1.55e-43 Hip circumference; CRC cis rs35306767 0.855 rs11253465 chr10:897208 A/C cg20503657 chr10:835505 NA 0.85 10.82 0.51 1.51e-23 Eosinophil percentage of granulocytes; CRC trans rs4276421 0.806 rs6451801 chr5:45439433 G/A cg04793272 chr11:119020941 ABCG4 -0.39 -6.42 -0.33 4.83e-10 P wave duration; CRC cis rs6951245 1.000 rs113146460 chr7:1105164 C/G cg24642844 chr7:1081250 C7orf50 -0.77 -9.29 -0.46 2.23e-18 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs853679 0.546 rs200490 chr6:27796935 G/T cg08798685 chr6:27730294 NA -0.63 -6.14 -0.32 2.38e-9 Depression; CRC cis rs9660992 0.590 rs1779411 chr1:205238530 C/T cg21643547 chr1:205240462 TMCC2 -0.46 -7.24 -0.37 3.1e-12 Mean corpuscular volume;Mean platelet volume; CRC cis rs12762955 0.561 rs11253567 chr10:1054444 A/G cg19847866 chr10:1019161 NA -0.41 -5.88 -0.31 1.01e-8 Response to angiotensin II receptor blocker therapy; CRC cis rs73206853 0.541 rs11837455 chr12:110505621 C/A cg12870014 chr12:110450643 ANKRD13A 0.87 7.64 0.39 2.42e-13 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg04067598 chr5:70751409 BDP1 0.46 6.37 0.33 6.19e-10 Response to antipsychotic treatment; CRC cis rs12477438 0.520 rs4851187 chr2:99745860 G/T cg26064155 chr2:99771622 LIPT1;TSGA10 -0.89 -16.54 -0.67 3.68e-45 Chronic sinus infection; CRC trans rs529967 1.000 rs529967 chr3:124166503 A/G cg01377916 chr16:46654868 SHCBP1 0.45 6.04 0.32 4.24e-9 Acute graft versus host disease in bone marrow transplantation (donor effect); CRC cis rs10504073 0.669 rs12548464 chr8:50023867 C/T cg00325661 chr8:49890786 NA 0.45 8.04 0.41 1.67e-14 Blood metabolite ratios; CRC cis rs10493773 1.000 rs12754358 chr1:86248431 C/T cg17807903 chr1:86174739 ZNHIT6 -0.5 -9.74 -0.47 7.21e-20 Urate levels in overweight individuals; CRC cis rs77861329 1.000 rs13314125 chr3:52115398 C/T cg08692210 chr3:52188851 WDR51A 0.83 6.95 0.36 1.95e-11 Macrophage inflammatory protein 1b levels; CRC cis rs1656402 0.569 rs80234614 chr2:233424159 A/T cg03852847 chr2:233439513 NA 0.45 7.52 0.38 5.2e-13 Non-small cell lung cancer (survival); CRC cis rs2153535 0.580 rs6926759 chr6:8456176 G/A cg21535247 chr6:8435926 SLC35B3 0.49 7.38 0.38 1.33e-12 Motion sickness; CRC cis rs9398803 0.865 rs9375439 chr6:126758540 C/G cg19875578 chr6:126661172 C6orf173 0.42 5.77 0.3 1.88e-8 Male-pattern baldness; CRC cis rs11628318 0.853 rs7140280 chr14:103026991 C/T cg23071808 chr14:103021642 NA -0.52 -6.89 -0.36 2.79e-11 Platelet count; CRC cis rs2842992 0.672 rs4708845 chr6:160219601 T/G cg19482086 chr6:160211437 TCP1;MRPL18 0.74 9.63 0.47 1.63e-19 Age-related macular degeneration (geographic atrophy); CRC trans rs6561151 0.718 rs11842000 chr13:44413467 T/C cg12856521 chr11:46389249 DGKZ 0.76 9.53 0.47 3.68e-19 Crohn's disease; CRC cis rs6445967 0.722 rs6445961 chr3:58232659 C/T cg23715586 chr3:58305044 RPP14 0.4 5.98 0.31 5.85e-9 Platelet count; CRC cis rs763121 0.853 rs5750652 chr22:39048316 A/G cg06022373 chr22:39101656 GTPBP1 0.81 13.71 0.6 3.61e-34 Menopause (age at onset); CRC cis rs7932354 0.528 rs7931260 chr11:47088303 T/C cg19486271 chr11:47235900 DDB2 -0.45 -6.46 -0.34 3.8e-10 Bone mineral density (hip);Bone mineral density; CRC cis rs4713118 0.513 rs149950 chr6:28033039 T/G cg21251018 chr6:28226885 NKAPL 0.47 7.29 0.37 2.36e-12 Parkinson's disease; CRC cis rs2276314 0.857 rs6507158 chr18:33636066 A/C cg19628046 chr18:33552617 C18orf21 0.55 7.91 0.4 4.08e-14 Endometriosis;Drug-induced torsades de pointes; CRC cis rs1577917 0.917 rs2084293 chr6:86566002 A/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.51 -6.59 -0.34 1.76e-10 Response to antipsychotic treatment; CRC cis rs806215 0.901 rs989100 chr7:127220918 T/C cg25922125 chr7:127225783 GCC1 -0.74 -7.76 -0.39 1.06e-13 Type 2 diabetes; CRC cis rs501120 0.925 rs535949 chr10:44752330 A/C cg09554077 chr10:44749378 NA -0.89 -13.36 -0.59 8.15e-33 Coronary artery disease;Coronary heart disease; CRC cis rs7618915 0.524 rs12488461 chr3:52698417 T/C cg05573699 chr3:52720067 GNL3;PBRM1 -0.45 -6.32 -0.33 8.47e-10 Bipolar disorder; CRC cis rs9311474 0.507 rs6787154 chr3:52784416 C/T cg11645453 chr3:52864694 ITIH4 0.37 6.57 0.34 2e-10 Electroencephalogram traits; CRC cis rs644799 1.000 rs693364 chr11:95621926 A/G cg25478527 chr11:95522999 CEP57;FAM76B 0.5 7.4 0.38 1.15e-12 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC trans rs875971 0.660 rs2191268 chr7:66110224 C/T cg08450636 chr7:93717240 NA -0.41 -6.43 -0.33 4.45e-10 Aortic root size; CRC cis rs362272 0.525 rs2798286 chr4:3046173 A/G cg22930642 chr4:2936657 C4orf10;MFSD10 -0.4 -5.72 -0.3 2.42e-8 Serum sulfate level; CRC cis rs10242455 0.557 rs45529541 chr7:99048143 C/A cg18809830 chr7:99032528 PTCD1 -0.93 -7.32 -0.37 1.89e-12 Blood metabolite levels; CRC cis rs1552244 1.000 rs17032276 chr3:10076975 A/C cg18598329 chr3:10140678 FANCD2;C3orf24 -0.89 -11.87 -0.55 2.69e-27 Alzheimer's disease; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg03132089 chr20:55926498 RAE1 0.43 6.24 0.33 1.33e-9 Anxiety disorder; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg07400628 chr1:6761934 DNAJC11 0.46 6.17 0.32 1.96e-9 Anxiety disorder; CRC cis rs6088580 0.634 rs945673 chr20:32964265 C/A cg08999081 chr20:33150536 PIGU -0.61 -11.39 -0.53 1.47e-25 Glomerular filtration rate (creatinine); CRC cis rs853679 0.760 rs967005 chr6:28210688 C/T cg21251018 chr6:28226885 NKAPL 0.51 5.95 0.31 6.9e-9 Depression; CRC cis rs9768139 0.708 rs921616 chr7:158117960 A/G cg24154853 chr7:158122151 PTPRN2 0.64 10.59 0.5 9.21e-23 Calcium levels; CRC cis rs10992471 0.639 rs10821008 chr9:95487497 C/T cg14631576 chr9:95140430 CENPP -0.39 -6.93 -0.36 2.25e-11 Visceral adipose tissue/subcutaneous adipose tissue ratio; CRC cis rs7833790 0.777 rs1005850 chr8:82692255 G/A cg27398817 chr8:82754497 SNX16 -0.49 -5.85 -0.31 1.17e-8 Diastolic blood pressure; CRC cis rs1707322 1.000 rs3922886 chr1:46473902 A/T cg03146154 chr1:46216737 IPP 0.49 6.85 0.35 3.62e-11 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC trans rs35110281 0.627 rs7283362 chr21:44973667 C/G cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.44 7.27 0.37 2.62e-12 Mean corpuscular volume; CRC cis rs478304 0.903 rs546202 chr11:65510024 C/T cg08755490 chr11:65554678 OVOL1 -0.43 -6.33 -0.33 7.93e-10 Acne (severe); CRC cis rs9768139 0.935 rs7782393 chr7:158120486 G/A cg23298862 chr7:158159286 PTPRN2 -0.48 -7.88 -0.4 4.73e-14 Calcium levels; CRC cis rs2276314 0.857 rs62101393 chr18:33592168 T/C cg05985134 chr18:33552581 C18orf21 0.45 6.2 0.32 1.7e-9 Endometriosis;Drug-induced torsades de pointes; CRC cis rs5769765 0.730 rs62233964 chr22:50317410 C/G cg02269571 chr22:50332266 NA -0.61 -7.6 -0.39 3.1e-13 Schizophrenia; CRC cis rs3771570 0.901 rs3821285 chr2:242421314 A/G cg21155796 chr2:242212141 HDLBP -0.57 -6.61 -0.34 1.54e-10 Prostate cancer; CRC cis rs1799949 0.931 rs34474989 chr17:41445410 A/T cg23758822 chr17:41437982 NA 0.85 15.97 0.66 6.78e-43 Menopause (age at onset); CRC cis rs11212617 1.000 rs227077 chr11:108253252 C/T cg01991180 chr11:108092276 ATM;NPAT 0.41 6.14 0.32 2.39e-9 Response to metformin in type 2 diabetes (glycemic); CRC cis rs597539 0.652 rs668576 chr11:68668208 A/G cg04772025 chr11:68637568 NA 0.48 7.41 0.38 1.09e-12 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs9910055 0.529 rs2523161 chr17:42179405 C/T cg13607699 chr17:42295918 UBTF -0.54 -7.28 -0.37 2.54e-12 Total body bone mineral density; CRC cis rs1799949 0.965 rs799917 chr17:41244936 G/A cg23758822 chr17:41437982 NA 0.92 18.19 0.71 1.2e-51 Menopause (age at onset); CRC cis rs736801 0.808 rs72797306 chr5:131800750 G/C cg02033258 chr5:131593261 PDLIM4 0.33 5.8 0.3 1.55e-8 Breast cancer;Mosquito bite size; CRC cis rs35417517 1 rs35417517 chr7:91772730 CG/C cg17063962 chr7:91808500 NA 0.84 14.85 0.63 1.52e-38 Breast cancer; CRC cis rs514406 0.861 rs4926576 chr1:53226775 C/T cg24675658 chr1:53192096 ZYG11B 0.53 7.8 0.39 8.34e-14 Monocyte count; CRC cis rs9649213 0.593 rs7458551 chr7:97952167 G/C cg24562669 chr7:97807699 LMTK2 0.42 7.02 0.36 1.3e-11 Prostate cancer (SNP x SNP interaction); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg23698501 chr2:220042748 FAM134A;C2orf24 0.46 6.49 0.34 3.14e-10 Response to antipsychotic treatment; CRC cis rs62400317 0.762 rs857601 chr6:44805214 G/T cg18551225 chr6:44695536 NA 0.42 5.8 0.3 1.57e-8 Total body bone mineral density; CRC cis rs873946 0.529 rs12258248 chr10:134573767 A/G cg26818010 chr10:134567672 INPP5A -0.6 -8.44 -0.42 1.05e-15 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CRC cis rs7208859 0.623 rs1061346 chr17:29114229 G/A cg13385521 chr17:29058706 SUZ12P 0.74 8.44 0.42 9.97e-16 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs10479542 0.752 rs12658664 chr5:178986987 C/T cg22764044 chr5:178986830 RUFY1 0.41 6.93 0.36 2.3e-11 Lung cancer; CRC cis rs4466137 0.953 rs6869030 chr5:83007311 C/T cg15083037 chr5:83017644 HAPLN1 -0.52 -7.0 -0.36 1.46e-11 Prostate cancer; CRC cis rs911555 0.755 rs2756135 chr14:103962579 G/A cg12935359 chr14:103987150 CKB 0.55 8.96 0.44 2.51e-17 Intelligence (multi-trait analysis); CRC cis rs2440129 0.632 rs2292353 chr17:6903537 C/T cg21237687 chr17:6899380 ALOX12 0.61 11.4 0.53 1.4e-25 Tonsillectomy; CRC cis rs7666738 0.830 rs13129479 chr4:98987860 T/C cg17366294 chr4:99064904 C4orf37 0.43 7.33 0.37 1.76e-12 Colonoscopy-negative controls vs population controls; CRC cis rs13315871 0.929 rs9871725 chr3:58292525 T/G cg20936604 chr3:58311152 NA -0.72 -6.84 -0.35 3.78e-11 Cholesterol, total; CRC cis rs13217239 0.646 rs7747454 chr6:27034253 T/G cg12292205 chr6:26970375 C6orf41 -0.52 -8.53 -0.43 5.27e-16 Schizophrenia; CRC cis rs12541335 0.639 rs11779277 chr8:22200683 C/T cg27266060 chr8:22091797 NA 0.36 6.06 0.32 3.79e-9 Hypertriglyceridemia; CRC cis rs881375 0.678 rs7031752 chr9:123663482 G/T cg09586646 chr9:123605570 PSMD5;LOC253039 0.47 7.08 0.36 8.85e-12 Rheumatoid arthritis; CRC cis rs9463078 0.625 rs12190513 chr6:44920679 A/T cg25276700 chr6:44698697 NA 0.24 5.85 0.31 1.22e-8 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; CRC cis rs10992471 0.603 rs10820968 chr9:95106443 A/G cg14631576 chr9:95140430 CENPP -0.4 -7.1 -0.36 7.68e-12 Visceral adipose tissue/subcutaneous adipose tissue ratio; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg21851282 chr13:106751175 NA 0.43 6.94 0.36 2.15e-11 Liver disease severity in Alagille syndrome; CRC cis rs1568889 0.838 rs7952717 chr11:28261658 C/T cg06544937 chr11:28130018 METT5D1;KIF18A 0.91 15.13 0.64 1.32e-39 Bipolar disorder; CRC cis rs9811920 0.603 rs2638948 chr3:99501539 G/T cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G -0.41 -5.78 -0.3 1.73e-8 Axial length; CRC cis rs9322193 0.923 rs9372044 chr6:150102003 G/A cg07701084 chr6:150067640 NUP43 0.47 6.61 0.34 1.51e-10 Lung cancer; CRC cis rs2243480 1.000 rs1499613 chr7:65730860 G/A cg18252515 chr7:66147081 NA 1.27 14.66 0.63 8.59e-38 Diabetic kidney disease; CRC cis rs11758351 1.000 rs16891405 chr6:26204506 A/G cg10723962 chr6:26240782 HIST1H4F -0.36 -5.61 -0.3 4.24e-8 Gout;Renal underexcretion gout; CRC cis rs6963495 0.818 rs73190167 chr7:105160418 A/G cg13798780 chr7:105162888 PUS7 0.68 8.08 0.41 1.27e-14 Bipolar disorder (body mass index interaction); CRC cis rs9311474 0.539 rs12489828 chr3:52567014 G/T cg13284614 chr3:52569169 NT5DC2;LOC440957 0.35 5.83 0.31 1.33e-8 Electroencephalogram traits; CRC cis rs2871473 0.951 rs1030025 chr2:103105611 A/T cg09003973 chr2:102972529 NA 0.48 6.3 0.33 9.76e-10 Blood protein levels; CRC cis rs600806 0.850 rs3768494 chr1:109935427 A/G cg23032129 chr1:109941072 SORT1 -0.27 -5.84 -0.31 1.24e-8 Intelligence (multi-trait analysis); CRC cis rs2769264 1.000 rs6684085 chr1:151357333 C/T cg18801370 chr1:151430492 POGZ -0.5 -5.95 -0.31 6.76e-9 Blood trace element (Cu levels); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg19764421 chr1:228783274 DUSP5P 0.41 6.73 0.35 7.48e-11 Liver disease severity in Alagille syndrome; CRC cis rs9488822 0.676 rs3798227 chr6:116324898 A/G cg26893134 chr6:116381904 FRK 0.26 7.61 0.39 2.98e-13 Cholesterol, total;LDL cholesterol; CRC cis rs6842047 1.000 rs1877320 chr4:187131279 G/A cg09526685 chr4:187126073 CYP4V2 0.47 6.72 0.35 8.19e-11 Blood protein levels; CRC cis rs8060686 0.641 rs112099181 chr16:68154230 T/C cg08314208 chr16:67682810 RLTPR -0.49 -5.88 -0.31 1.01e-8 HDL cholesterol;Metabolic syndrome; CRC cis rs875971 0.545 rs10261710 chr7:65714189 T/A cg05627663 chr7:65219948 SNORA22;CCT6P1 0.62 8.1 0.41 1.1e-14 Aortic root size; CRC cis rs4243830 0.850 rs10779787 chr1:6599755 C/G cg15205204 chr1:6545172 PLEKHG5 0.4 5.73 0.3 2.26e-8 Body mass index; CRC cis rs17539620 0.624 rs871068 chr6:154837514 C/A cg20019720 chr6:154832845 CNKSR3 0.5 8.15 0.41 7.51e-15 Lipoprotein (a) levels; CRC cis rs477895 0.653 rs34113693 chr11:63900123 G/T cg04317338 chr11:64019027 PLCB3 0.6 7.28 0.37 2.53e-12 Mean platelet volume; CRC cis rs4481887 0.927 rs6678798 chr1:248476617 C/T cg13385794 chr1:248469461 NA 0.38 6.75 0.35 6.84e-11 Common traits (Other); CRC cis rs7613875 0.620 rs7430334 chr3:50078221 T/C cg24110177 chr3:50126178 RBM5 0.58 9.13 0.45 6.99e-18 Body mass index; CRC cis rs7615952 0.599 rs7631268 chr3:125755664 T/A cg02772935 chr3:125709198 NA -0.5 -5.71 -0.3 2.53e-8 Blood pressure (smoking interaction); CRC cis rs1059312 1.000 rs12814773 chr12:129280786 C/T cg09035930 chr12:129282057 SLC15A4 0.55 9.3 0.46 2.08e-18 Systemic lupus erythematosus; CRC cis rs6908034 0.607 rs73376657 chr6:19805960 C/T cg02682789 chr6:19804855 NA 0.79 6.75 0.35 6.62e-11 Endometriosis;Deep ovarian and/or rectovaginal disease with dense adhesions; CRC trans rs2303319 0.504 rs55650699 chr2:162388931 T/C cg27113153 chr11:123612418 ZNF202 -0.72 -6.15 -0.32 2.25e-9 Cognitive function; CRC cis rs990171 1.000 rs1468791 chr2:103092021 A/G cg03938978 chr2:103052716 IL18RAP 0.45 5.78 0.3 1.77e-8 Lymphocyte counts; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg17170942 chr3:124452405 UMPS -0.38 -6.28 -0.33 1.06e-9 Liver disease severity in Alagille syndrome; CRC cis rs9814567 1.000 rs62271513 chr3:134298412 T/G cg06109529 chr3:134205091 CEP63;ANAPC13 0.82 11.96 0.55 1.33e-27 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs9341808 0.754 rs3805885 chr6:80996751 C/G cg08355045 chr6:80787529 NA -0.36 -5.73 -0.3 2.32e-8 Sitting height ratio; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg15877295 chr7:138915876 UBN2 0.47 6.75 0.35 6.73e-11 Response to antipsychotic treatment; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg12049485 chr15:78858219 CHRNA5 0.41 6.62 0.34 1.49e-10 Liver disease severity in Alagille syndrome; CRC trans rs61931739 0.500 rs7298322 chr12:34445489 A/T cg26384229 chr12:38710491 ALG10B 0.62 9.11 0.45 8.27e-18 Morning vs. evening chronotype; CRC cis rs2120019 1.000 rs34237279 chr15:75361121 A/G cg11632617 chr15:75315747 PPCDC -0.57 -8.05 -0.41 1.49e-14 Blood trace element (Zn levels); CRC cis rs1348850 0.831 rs1345139 chr2:178449791 G/T cg02961200 chr2:178257176 LOC100130691;AGPS 0.44 6.31 0.33 8.96e-10 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs950169 0.800 rs4099846 chr15:84956894 C/G cg11189052 chr15:85197271 WDR73 0.63 8.8 0.44 7.65e-17 Schizophrenia; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg18886436 chr12:54785171 ZNF385A 0.37 6.36 0.33 6.88e-10 Liver disease severity in Alagille syndrome; CRC cis rs6681460 0.800 rs485543 chr1:67194372 C/T cg02459107 chr1:67143332 SGIP1 -0.35 -5.82 -0.31 1.42e-8 Presence of antiphospholipid antibodies; CRC cis rs2075371 0.830 rs1421478 chr7:133922793 T/A cg20476274 chr7:133979776 SLC35B4 0.7 11.26 0.53 4.27e-25 Mean platelet volume; CRC trans rs12599106 0.792 rs76039834 chr16:34598453 G/A cg26668828 chr6:292823 DUSP22 -0.59 -8.79 -0.44 8.46e-17 Menopause (age at onset); CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg08237663 chr3:130745839 NEK11;ASTE1 -0.51 -6.0 -0.31 5.08e-9 Diisocyanate-induced asthma; CRC cis rs807029 0.533 rs2295716 chr10:102744214 T/C cg04662943 chr10:102668895 NA 0.61 7.3 0.37 2.2e-12 Ejection fraction in Tripanosoma cruzi seropositivity; CRC cis rs4721295 0.502 rs2058430 chr7:2206110 A/G cg04267008 chr7:1944627 MAD1L1 -0.45 -5.62 -0.3 4.18e-8 Schizophrenia, schizoaffective disorder or bipolar disorder; CRC cis rs2346177 0.519 rs2121698 chr2:46709571 C/T cg26688816 chr2:46740690 ATP6V1E2 -0.62 -9.45 -0.46 6.72e-19 HDL cholesterol; CRC cis rs13256369 1.000 rs4841017 chr8:8577093 A/G cg18904891 chr8:8559673 CLDN23 0.51 7.32 0.37 1.92e-12 Obesity-related traits; CRC cis rs2243480 1.000 rs1553174 chr7:65731194 T/C cg25985355 chr7:65971099 NA 0.51 5.72 0.3 2.46e-8 Diabetic kidney disease; CRC cis rs11785400 0.762 rs7017931 chr8:143726728 A/G cg10596483 chr8:143751796 JRK 0.47 6.37 0.33 6.37e-10 Schizophrenia; CRC cis rs7789940 0.817 rs6946310 chr7:75936099 T/C cg10167463 chr7:75959203 YWHAG -0.53 -7.59 -0.39 3.25e-13 Multiple sclerosis; CRC cis rs868943 0.512 rs72953957 chr6:116546543 A/G cg15226275 chr6:116381976 FRK 0.26 6.13 0.32 2.58e-9 Total cholesterol levels; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg15605853 chr6:47755961 OPN5 0.43 6.21 0.32 1.64e-9 Response to antipsychotic treatment; CRC trans rs1568657 0.779 rs2167602 chr15:83649292 C/T cg26552321 chr15:43477455 CCNDBP1 -0.45 -6.01 -0.31 4.95e-9 Kawasaki disease; CRC trans rs8073060 0.586 rs8074800 chr17:33979148 A/G cg19694781 chr19:47549865 TMEM160 1.07 16.1 0.66 1.96e-43 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; CRC trans rs2303319 0.504 rs1006427 chr2:162592328 T/C cg10272801 chr16:14013773 ERCC4 -0.68 -6.07 -0.32 3.49e-9 Cognitive function; CRC cis rs2228479 0.850 rs11642010 chr16:89845111 T/C cg06558623 chr16:89946397 TCF25 1.14 9.86 0.48 2.84e-20 Skin colour saturation; CRC cis rs912057 0.671 rs1294428 chr6:6744623 A/G cg06612196 chr6:6737390 NA 0.54 8.59 0.43 3.49e-16 Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction); CRC cis rs7666738 0.962 rs4699596 chr4:99012924 C/T cg03676636 chr4:99064102 C4orf37 0.25 6.96 0.36 1.89e-11 Colonoscopy-negative controls vs population controls; CRC cis rs11676348 0.818 rs1126579 chr2:219000734 T/C cg00012203 chr2:219082015 ARPC2 -0.44 -6.47 -0.34 3.61e-10 Ulcerative colitis; CRC cis rs6460942 0.731 rs7799372 chr7:12233784 T/A cg06484146 chr7:12443880 VWDE -0.58 -6.08 -0.32 3.36e-9 Coronary artery disease; CRC cis rs2239547 0.657 rs4687554 chr3:52864135 T/C cg10802521 chr3:52805072 NEK4 -0.45 -6.11 -0.32 2.79e-9 Schizophrenia; CRC cis rs2739330 0.828 rs2877178 chr22:24251517 C/T cg24846343 chr22:24311635 DDTL 0.85 15.05 0.64 2.54e-39 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs1552244 0.554 rs6762397 chr3:10007840 C/T cg16606324 chr3:10149918 C3orf24 0.47 6.98 0.36 1.59e-11 Alzheimer's disease; CRC cis rs6570726 0.935 rs408768 chr6:145871735 A/G cg23711669 chr6:146136114 FBXO30 0.71 12.45 0.57 2.02e-29 Lobe attachment (rater-scored or self-reported); CRC cis rs6951245 1.000 rs79617366 chr7:1111958 G/C cg26224354 chr7:1096374 C7orf50;GPR146 -0.95 -12.37 -0.56 4.18e-29 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs916888 0.773 rs169201 chr17:44790203 A/G cg15921436 chr17:44337874 NA 0.81 8.51 0.42 6.37e-16 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs6908034 0.607 rs76413455 chr6:19808964 T/G cg02682789 chr6:19804855 NA 0.79 6.58 0.34 1.81e-10 Endometriosis;Deep ovarian and/or rectovaginal disease with dense adhesions; CRC trans rs10506458 0.915 rs12423078 chr12:63397529 C/T cg03429785 chr15:59498649 MYO1E;LDHAL6B -1.42 -20.73 -0.75 1.2e-61 Hemostatic factors and hematological phenotypes; CRC cis rs1570989 0.571 rs6916066 chr6:12016009 G/C cg17804551 chr6:12015979 HIVEP1 0.4 6.44 0.33 4.22e-10 Alcohol and nicotine co-dependence; CRC cis rs17155006 0.628 rs397941 chr7:107727709 C/T cg05962710 chr7:107745446 LAMB4 -0.35 -5.85 -0.31 1.16e-8 Pneumococcal bacteremia; CRC cis rs4972806 0.739 rs10834 chr2:177042087 A/G cg03152288 chr2:177042942 NA 0.67 9.5 0.46 4.67e-19 IgG glycosylation; CRC cis rs6479527 0.840 rs1576640 chr9:96770131 A/G cg14459158 chr9:96720562 NA 0.37 6.62 0.34 1.46e-10 Esophageal adenocarcinoma; CRC cis rs427943 0.639 rs2838820 chr21:46646005 A/G cg19498844 chr21:46707878 POFUT2;LOC642852 0.42 5.73 0.3 2.26e-8 Body mass index; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg09936566 chr1:163292020 NUF2 0.45 6.54 0.34 2.32e-10 Intelligence (multi-trait analysis); CRC cis rs2228479 0.702 rs3819574 chr16:89826630 G/A cg06558623 chr16:89946397 TCF25 1.13 10.45 0.5 2.85e-22 Skin colour saturation; CRC cis rs4665809 1.000 rs4665816 chr2:26305094 G/C cg27170947 chr2:26402098 FAM59B -0.45 -6.17 -0.32 2.06e-9 Gut microbiome composition (summer); CRC cis rs12908161 0.959 rs12908699 chr15:85240403 G/T cg11189052 chr15:85197271 WDR73 0.62 8.91 0.44 3.47e-17 Schizophrenia; CRC cis rs11212617 1.000 rs654005 chr11:108155397 G/A cg12106634 chr11:108092400 ATM;NPAT 0.42 6.17 0.32 1.95e-9 Response to metformin in type 2 diabetes (glycemic); CRC cis rs3087591 1.000 rs7214792 chr17:29460673 G/A cg24425628 chr17:29625626 OMG;NF1 0.88 16.69 0.68 9.63e-46 Hip circumference; CRC cis rs7312933 0.558 rs1669886 chr12:42838240 A/G cg19980929 chr12:42632907 YAF2 -0.4 -6.18 -0.32 1.9e-9 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CRC cis rs145445141 1 rs145445141 chr1:67489169 ATT/A cg08660285 chr1:67390436 MIER1;WDR78 0.93 10.99 0.52 3.81e-24 Neutrophil percentage of white cells; CRC cis rs9381040 0.655 rs2268193 chr6:41024625 A/G cg03644281 chr6:41068752 NFYA;LOC221442 -0.44 -6.33 -0.33 8.04e-10 Alzheimer's disease (late onset); CRC cis rs1552244 1.000 rs66838678 chr3:10150350 G/A cg18598329 chr3:10140678 FANCD2;C3orf24 -0.89 -11.93 -0.55 1.67e-27 Alzheimer's disease; CRC cis rs12142240 0.667 rs66990604 chr1:46822073 G/A cg00530320 chr1:46809349 NSUN4 0.59 8.03 0.41 1.69e-14 Menopause (age at onset); CRC cis rs4973397 0.643 rs2369271 chr2:232289244 C/T cg13347044 chr2:232276743 NA -0.39 -5.63 -0.3 3.84e-8 Anti-saccade response; CRC cis rs7618915 0.570 rs2336145 chr3:52629750 A/C cg11645453 chr3:52864694 ITIH4 0.36 6.25 0.33 1.28e-9 Bipolar disorder; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg07364046 chr12:93861583 MRPL42 0.43 6.22 0.32 1.51e-9 Response to antipsychotic treatment; CRC cis rs7618915 0.547 rs34215106 chr3:52659124 T/C cg07507251 chr3:52567010 NT5DC2 0.43 6.15 0.32 2.19e-9 Bipolar disorder; CRC cis rs763014 0.932 rs2384974 chr16:651279 C/G cg04497992 chr16:616212 NHLRC4 0.44 7.16 0.37 5.17e-12 Height; CRC cis rs7666738 0.830 rs7678557 chr4:99057329 A/G cg17366294 chr4:99064904 C4orf37 0.45 7.68 0.39 1.83e-13 Colonoscopy-negative controls vs population controls; CRC cis rs7103648 0.695 rs7933019 chr11:47509137 G/C cg20307385 chr11:47447363 PSMC3 0.86 12.62 0.57 4.91e-30 Diastolic blood pressure;Systolic blood pressure; CRC cis rs7113874 0.589 rs10840056 chr11:8498064 A/C cg20771178 chr11:8615675 STK33 0.34 5.67 0.3 3.07e-8 Body mass index in physically active individuals;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs9549328 0.700 rs3011473 chr13:113618096 A/G cg17524180 chr13:113633600 MCF2L 0.53 9.57 0.47 2.68e-19 Systolic blood pressure; CRC cis rs2976388 0.609 rs2572904 chr8:143792193 A/C cg05569086 chr8:143859399 LYNX1 0.4 6.96 0.36 1.91e-11 Urinary tract infection frequency; CRC cis rs2976388 0.566 rs13250661 chr8:143804134 C/T cg24046110 chr8:143859143 LYNX1 -0.46 -7.44 -0.38 8.99e-13 Urinary tract infection frequency; CRC cis rs4713118 0.786 rs200502 chr6:27788062 C/T cg25164649 chr6:28176230 NA 0.58 7.24 0.37 3.2e-12 Parkinson's disease; CRC cis rs2439831 0.850 rs7183809 chr15:44120868 T/G cg02155558 chr15:43621948 ADAL;LCMT2 0.64 7.26 0.37 2.89e-12 Lung cancer in ever smokers; CRC cis rs2739330 0.796 rs1006771 chr22:24314006 G/T cg16132339 chr22:24313637 DDTL;DDT 0.56 8.95 0.44 2.74e-17 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs561341 0.609 rs7209493 chr17:30197323 A/G cg00745463 chr17:30367425 LRRC37B 0.51 6.26 0.33 1.22e-9 Hip circumference adjusted for BMI; CRC cis rs9649213 0.593 rs6465678 chr7:98004057 T/C cg21770322 chr7:97807741 LMTK2 0.51 8.29 0.42 2.98e-15 Prostate cancer (SNP x SNP interaction); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg02021460 chr16:19729639 C16orf88;IQCK 0.44 6.08 0.32 3.32e-9 Response to antipsychotic treatment; CRC cis rs1799949 1.000 rs33918839 chr17:41329172 T/C cg01879757 chr17:41196368 BRCA1 -0.43 -6.62 -0.34 1.51e-10 Menopause (age at onset); CRC cis rs1691799 0.899 rs1168308 chr12:66742183 A/G cg16791601 chr12:66731901 HELB -0.67 -11.29 -0.53 3.27e-25 White blood cell count (basophil); CRC cis rs67311347 1.000 rs73080126 chr3:40509153 A/G cg09455208 chr3:40491958 NA 0.51 9.88 0.48 2.58e-20 Renal cell carcinoma; CRC cis rs950169 0.959 rs12911210 chr15:84792083 A/C cg03959625 chr15:84868606 LOC388152 0.42 6.39 0.33 5.74e-10 Schizophrenia; CRC cis rs13315871 1.000 rs13327709 chr3:58408767 C/T cg20936604 chr3:58311152 NA -0.75 -7.12 -0.37 6.99e-12 Cholesterol, total; CRC cis rs1448094 0.511 rs6539921 chr12:86164163 G/A cg18827107 chr12:86230957 RASSF9 -0.38 -5.81 -0.3 1.5e-8 Major depressive disorder; CRC cis rs7833986 0.501 rs2667978 chr8:56897951 A/G cg23139584 chr8:56987506 RPS20;SNORD54 0.74 10.89 0.51 8.89e-24 Height; CRC cis rs2153535 0.580 rs1414348 chr6:8471940 A/G cg21535247 chr6:8435926 SLC35B3 0.5 7.5 0.38 5.89e-13 Motion sickness; CRC cis rs4664293 0.967 rs13000070 chr2:160525774 C/G cg08347373 chr2:160653686 CD302 -0.47 -7.58 -0.39 3.51e-13 Monocyte percentage of white cells; CRC cis rs3771570 0.579 rs62190373 chr2:242388685 G/A cg21155796 chr2:242212141 HDLBP 0.63 6.82 0.35 4.31e-11 Prostate cancer; CRC cis rs6762 0.748 rs7929032 chr11:839078 G/A cg11173246 chr11:841376 TSPAN4;POLR2L -0.34 -5.71 -0.3 2.51e-8 Mean platelet volume; CRC cis rs853679 0.517 rs9348796 chr6:28126202 A/G cg12172441 chr6:28176163 NA 0.64 7.53 0.38 5.03e-13 Depression; CRC cis rs7666738 0.830 rs34273190 chr4:99004568 C/T cg05340658 chr4:99064831 C4orf37 0.61 9.44 0.46 7.24e-19 Colonoscopy-negative controls vs population controls; CRC cis rs921968 0.643 rs4674320 chr2:219510768 A/G cg02176678 chr2:219576539 TTLL4 0.5 7.98 0.4 2.39e-14 Mean corpuscular hemoglobin concentration; CRC cis rs11785400 1.000 rs4327844 chr8:143733540 C/T cg10596483 chr8:143751796 JRK -0.46 -6.58 -0.34 1.84e-10 Schizophrenia; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg05755010 chr1:147142917 ACP6 0.4 6.06 0.32 3.64e-9 Intelligence (multi-trait analysis); CRC cis rs11122272 0.735 rs2572254 chr1:231512593 T/C cg06096015 chr1:231504339 EGLN1 0.38 5.64 0.3 3.66e-8 Hemoglobin concentration; CRC cis rs8014204 0.604 rs2159906 chr14:75390912 G/T cg06998765 chr14:75389618 RPS6KL1 -0.25 -5.99 -0.31 5.44e-9 Caffeine consumption; CRC trans rs11039798 0.844 rs11040177 chr11:48976211 G/C cg03929089 chr4:120376271 NA 0.64 6.1 0.32 2.95e-9 Axial length; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg02896705 chr19:18112042 ARRDC2 0.38 6.44 0.33 4.15e-10 Liver disease severity in Alagille syndrome; CRC cis rs4803468 0.967 rs67047091 chr19:41938684 C/T cg09537434 chr19:41945824 ATP5SL 0.97 18.25 0.71 6.72e-52 Height; CRC cis rs17021463 0.676 rs12512832 chr4:95310216 G/T cg11021082 chr4:95130006 SMARCAD1 0.43 6.17 0.32 2.02e-9 Testicular germ cell tumor; CRC cis rs11148252 0.574 rs73186430 chr13:53232891 T/C cg20354231 chr13:53171401 NA -0.46 -7.3 -0.37 2.15e-12 Lewy body disease; CRC cis rs17666538 0.792 rs1703912 chr8:600643 A/G cg26554054 chr8:600488 NA 0.7 6.84 0.35 3.84e-11 IgG glycosylation; CRC cis rs10927875 0.541 rs1763596 chr1:16343835 C/T cg10494257 chr1:16342123 HSPB7 0.45 6.31 0.33 8.91e-10 Dilated cardiomyopathy; CRC cis rs1580019 0.961 rs4357201 chr7:32496333 T/C cg07520158 chr7:32535189 LSM5;AVL9 0.45 6.42 0.33 4.87e-10 Cognitive ability; CRC cis rs875971 0.508 rs6947808 chr7:66045082 A/G cg11764359 chr7:65958608 NA -0.5 -7.75 -0.39 1.14e-13 Aortic root size; CRC cis rs9341808 0.935 rs1535825 chr6:80938586 C/T cg08355045 chr6:80787529 NA -0.36 -6.25 -0.33 1.28e-9 Sitting height ratio; CRC cis rs57590327 0.503 rs1464790 chr3:81852923 A/T cg07356753 chr3:81810745 GBE1 0.59 8.11 0.41 1.01e-14 Extraversion; CRC cis rs3956705 0.866 rs71532543 chr7:32998910 G/A cg05721444 chr7:32995514 FKBP9 -0.51 -7.22 -0.37 3.63e-12 Red cell distribution width; CRC cis rs7618915 0.547 rs62253733 chr3:52653414 A/G cg10802521 chr3:52805072 NEK4 -0.58 -8.83 -0.44 6.26e-17 Bipolar disorder; CRC cis rs9527 0.590 rs12785223 chr10:104844011 C/T cg15744005 chr10:104629667 AS3MT 0.3 5.92 0.31 8.06e-9 Arsenic metabolism; CRC cis rs1881797 0.527 rs74227706 chr1:247638315 A/C cg05639522 chr1:247681581 NA 0.56 6.05 0.32 3.95e-9 Acute lymphoblastic leukemia (childhood); CRC cis rs801193 1.000 rs62466793 chr7:66191517 G/A cg11764359 chr7:65958608 NA 0.54 8.35 0.42 1.86e-15 Aortic root size; CRC cis rs9611565 0.512 rs2050033 chr22:42159229 G/T cg06634786 chr22:41940651 POLR3H 0.66 7.27 0.37 2.62e-12 Vitiligo; CRC cis rs8072100 1.000 rs8065669 chr17:45724996 G/A cg25173405 chr17:45401733 C17orf57 -0.46 -7.32 -0.37 1.91e-12 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs7208859 0.524 rs57670615 chr17:29069498 A/G cg01831904 chr17:28903510 LRRC37B2 -0.62 -6.39 -0.33 5.8e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs7662987 0.517 rs1453873 chr4:100022571 T/C cg12011299 chr4:100065546 ADH4 0.49 9.27 0.46 2.46e-18 Smoking initiation; CRC cis rs7635838 0.617 rs2122031 chr3:11314143 G/A cg00170343 chr3:11313890 ATG7 0.59 9.22 0.45 3.77e-18 HDL cholesterol; CRC cis rs2032447 0.839 rs199751 chr6:26015583 T/C cg26028573 chr6:26043587 HIST1H2BB 0.51 7.45 0.38 8.07e-13 Intelligence (multi-trait analysis); CRC trans rs11098499 0.909 rs10014719 chr4:120320715 G/A cg25214090 chr10:38739885 LOC399744 0.66 10.45 0.5 3.01e-22 Corneal astigmatism; CRC cis rs6662572 0.901 rs28484896 chr1:46184200 C/G cg08644498 chr1:46502608 NA 0.43 6.48 0.34 3.35e-10 Blood protein levels; CRC cis rs9814567 0.727 rs9809344 chr3:134342758 T/C cg06109529 chr3:134205091 CEP63;ANAPC13 -0.62 -8.82 -0.44 6.77e-17 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs1707322 1.000 rs4660336 chr1:46487976 T/C cg06784218 chr1:46089804 CCDC17 -0.52 -9.41 -0.46 8.67e-19 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs6502050 0.835 rs8075086 chr17:80092649 A/G cg19223190 chr17:80058835 NA 0.39 6.32 0.33 8.71e-10 Life satisfaction; CRC cis rs2276314 1.000 rs62101367 chr18:33550884 C/T cg19628046 chr18:33552617 C18orf21 0.53 7.15 0.37 5.8e-12 Endometriosis;Drug-induced torsades de pointes; CRC cis rs9381040 0.701 rs6933231 chr6:41163700 T/C cg25110423 chr6:41068646 NFYA;LOC221442 -0.4 -6.38 -0.33 6.12e-10 Alzheimer's disease (late onset); CRC cis rs10504229 0.679 rs72649115 chr8:58037631 T/G cg24829409 chr8:58192753 C8orf71 -0.61 -7.48 -0.38 6.81e-13 Developmental language disorder (linguistic errors); CRC cis rs1448094 0.967 rs10746357 chr12:86341044 A/T cg18827107 chr12:86230957 RASSF9 -0.38 -6.29 -0.33 1.03e-9 Major depressive disorder; CRC cis rs912057 0.695 rs1294419 chr6:6742549 C/G cg06612196 chr6:6737390 NA 0.51 8.21 0.41 5.12e-15 Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction); CRC cis rs17253792 0.822 rs79538158 chr14:56051365 G/T cg01858014 chr14:56050164 KTN1 -0.88 -7.09 -0.36 8.36e-12 Putamen volume; CRC cis rs736408 0.677 rs1042779 chr3:52821011 A/G cg08222913 chr3:52553049 STAB1 -0.33 -6.09 -0.32 3.17e-9 Bipolar disorder; CRC cis rs896854 0.625 rs4735335 chr8:95973327 G/C cg23172400 chr8:95962367 TP53INP1 -0.48 -8.17 -0.41 6.79e-15 Type 2 diabetes; CRC cis rs9837602 0.507 rs6803204 chr3:99680874 G/A cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G -0.46 -6.19 -0.32 1.79e-9 Breast cancer; CRC cis rs861020 1.000 rs595918 chr1:209966843 A/G cg05527609 chr1:210001259 C1orf107 0.88 11.19 0.53 7.32e-25 Orofacial clefts; CRC cis rs2370759 0.898 rs113412621 chr10:32579306 C/T cg01819863 chr10:32635814 EPC1 1.09 12.78 0.58 1.25e-30 Sexual dysfunction (female); CRC cis rs1003719 0.591 rs2835618 chr21:38503126 A/G cg10648535 chr21:38446584 PIGP;TTC3 -0.44 -6.17 -0.32 1.98e-9 Eye color traits; CRC cis rs9322193 0.887 rs3734295 chr6:149915053 C/T cg07701084 chr6:150067640 NUP43 0.57 8.17 0.41 6.87e-15 Lung cancer; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg04703844 chr8:74207197 RPL7;RDH10 0.47 6.04 0.32 4.22e-9 Thyroid stimulating hormone; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg02951150 chr4:185654545 MLF1IP 0.37 5.97 0.31 6.15e-9 Liver disease severity in Alagille syndrome; CRC cis rs11122272 0.735 rs2491408 chr1:231519248 C/G cg06096015 chr1:231504339 EGLN1 0.4 5.94 0.31 7.17e-9 Hemoglobin concentration; CRC cis rs4731207 0.505 rs7795233 chr7:124578468 A/G cg23710748 chr7:124431027 NA -0.39 -6.12 -0.32 2.67e-9 Cutaneous malignant melanoma; CRC cis rs10131894 0.611 rs175002 chr14:75436466 C/G cg11812906 chr14:75593930 NEK9 0.44 6.64 0.34 1.27e-10 Coronary artery disease; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg10573403 chr14:36003118 INSM2 0.4 6.52 0.34 2.6e-10 Response to antipsychotic treatment; CRC trans rs10435719 0.902 rs11250179 chr8:11800332 C/T cg08975724 chr8:8085496 FLJ10661 0.41 6.14 0.32 2.39e-9 C-reactive protein levels or triglyceride levels (pleiotropy); CRC cis rs7804356 0.906 rs73069541 chr7:26904928 A/G cg03456212 chr7:26904342 SKAP2 -0.53 -5.96 -0.31 6.53e-9 Type 1 diabetes; CRC cis rs13108904 0.870 rs1564508 chr4:1244879 A/G cg19318889 chr4:1322082 MAEA 0.42 6.43 0.33 4.55e-10 Obesity-related traits; CRC cis rs12476592 0.516 rs1922421 chr2:63592792 G/A cg10828910 chr2:63850056 LOC388955 0.47 5.87 0.31 1.07e-8 Childhood ear infection; CRC cis rs55788414 0.860 rs28697180 chr16:81185079 C/T cg06400318 chr16:81190750 PKD1L2 -0.59 -6.76 -0.35 6.2e-11 Left ventricular obstructive tract defect (maternal effect); CRC cis rs6693567 0.545 rs2133129 chr1:150355537 T/C cg15654264 chr1:150340011 RPRD2 0.42 6.06 0.32 3.72e-9 Migraine; CRC cis rs230203 0.506 rs230193 chr20:55774246 C/T cg13236649 chr20:55835020 BMP7 0.38 5.66 0.3 3.29e-8 Monobrow; CRC cis rs9467603 0.925 rs28412066 chr6:25775570 T/A cg16898833 chr6:26189333 HIST1H4D -0.72 -6.04 -0.32 4.25e-9 Intelligence (multi-trait analysis); CRC trans rs6560039 1 rs6560039 chr9:90474946 C/T cg24436365 chr6:63940138 NA 0.55 11.27 0.53 3.93e-25 Gait variability; CRC cis rs2120019 1.000 rs67544533 chr15:75361539 A/G cg11632617 chr15:75315747 PPCDC -0.57 -8.25 -0.41 3.96e-15 Blood trace element (Zn levels); CRC cis rs9910055 0.529 rs228748 chr17:42174390 G/A cg10896456 chr17:42255109 ASB16;C17orf65 -0.41 -6.42 -0.33 4.82e-10 Total body bone mineral density; CRC cis rs972578 0.905 rs9623736 chr22:43406673 A/G cg01576275 chr22:43409880 NA -0.51 -8.44 -0.42 1e-15 Mean platelet volume; CRC cis rs4689388 0.853 rs11729672 chr4:6293838 A/G cg14416269 chr4:6271139 WFS1 0.4 6.62 0.34 1.43e-10 Type 2 diabetes and other traits;Type 2 diabetes; CRC cis rs2565722 0.714 rs2489935 chr6:161280245 T/C cg03159191 chr6:161285451 NA -0.5 -6.02 -0.31 4.67e-9 Blood protein levels; CRC cis rs2795502 0.564 rs72777192 chr10:43436778 G/A cg20628663 chr10:43360327 NA 0.57 6.85 0.35 3.55e-11 Blood protein levels; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg01524359 chr1:46049306 NASP 0.51 6.56 0.34 2.15e-10 Thyroid stimulating hormone; CRC cis rs2739330 0.760 rs1002286 chr22:24257337 A/G cg15242686 chr22:24348715 GSTTP1 -0.4 -6.29 -0.33 9.98e-10 Liver enzyme levels (gamma-glutamyl transferase); CRC trans rs2235573 0.625 rs139901 chr22:38406147 T/C cg19894588 chr14:64061835 NA 0.43 6.09 0.32 3.1e-9 Glioblastoma;Glioma; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg15884411 chr2:96932403 CIAO1;TMEM127 0.44 6.12 0.32 2.63e-9 Response to antipsychotic treatment; CRC cis rs7552404 0.727 rs4949677 chr1:76266662 T/A cg03433033 chr1:76189801 ACADM 0.7 9.06 0.45 1.23e-17 Blood metabolite levels;Acylcarnitine levels; CRC cis rs9322193 0.923 rs4455682 chr6:150021297 C/T cg00933542 chr6:150070202 PCMT1 0.3 6.26 0.33 1.17e-9 Lung cancer; CRC cis rs6933660 0.646 rs9397051 chr6:151778325 C/T cg14262678 chr6:151773367 RMND1;C6orf211 0.6 10.21 0.49 1.87e-21 Menarche (age at onset); CRC cis rs6089584 0.606 rs7270469 chr20:60577258 G/A cg13770153 chr20:60521292 NA -0.41 -6.49 -0.34 3.09e-10 Body mass index; CRC cis rs8062405 1.000 rs62036621 chr16:28833299 C/A cg16576597 chr16:28551801 NUPR1 0.49 7.07 0.36 9.42e-12 Cognitive ability (multi-trait analysis);Cognitive ability; CRC cis rs4862750 0.915 rs6835681 chr4:187903476 A/G cg03647317 chr4:187891568 NA -0.51 -9.18 -0.45 4.84e-18 Lobe attachment (rater-scored or self-reported); CRC cis rs9660992 0.710 rs55671824 chr1:205249814 G/A cg21643547 chr1:205240462 TMCC2 -0.45 -7.26 -0.37 2.8e-12 Mean corpuscular volume;Mean platelet volume; CRC trans rs10983614 1.000 rs7867776 chr9:120072627 A/G cg25937148 chr3:43147320 C3orf39 0.47 6.71 0.35 8.51e-11 Survival in pancreatic cancer; CRC cis rs9486719 1.000 rs6923212 chr6:97061940 A/G cg18709589 chr6:96969512 KIAA0776 -0.5 -5.66 -0.3 3.23e-8 Migraine;Coronary artery disease; CRC cis rs35883536 0.900 rs7520474 chr1:101091376 T/C cg14515779 chr1:101123966 NA 0.36 6.65 0.34 1.22e-10 Monocyte count; CRC cis rs10197940 0.662 rs6735771 chr2:152273503 G/A cg06191203 chr2:152266755 RIF1 0.59 8.71 0.43 1.53e-16 Lung cancer; CRC cis rs812925 0.893 rs1186705 chr2:61673278 A/C cg10580144 chr2:61372316 C2orf74 0.3 6.13 0.32 2.47e-9 Immature fraction of reticulocytes; CRC cis rs2239547 0.522 rs9842974 chr3:53011050 C/A cg18404041 chr3:52824283 ITIH1 -0.35 -6.55 -0.34 2.21e-10 Schizophrenia; CRC cis rs7833790 0.963 rs72686466 chr8:82758928 G/T cg27398817 chr8:82754497 SNX16 0.57 6.82 0.35 4.48e-11 Diastolic blood pressure; CRC cis rs9368481 1.000 rs9368481 chr6:26961761 C/T cg05192639 chr6:26864778 GUSBL1 -0.37 -6.5 -0.34 3.05e-10 Autism spectrum disorder or schizophrenia; CRC cis rs514406 0.861 rs2477741 chr1:53265278 A/G cg27535305 chr1:53392650 SCP2 0.39 7.01 0.36 1.34e-11 Monocyte count; CRC cis rs1008375 0.966 rs2159582 chr4:17695655 T/C cg16339924 chr4:17578868 LAP3 0.49 6.6 0.34 1.68e-10 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs9322193 0.607 rs12527391 chr6:150203292 T/C cg13206674 chr6:150067644 NUP43 0.47 5.75 0.3 2.03e-8 Lung cancer; CRC cis rs7647973 0.621 rs3774800 chr3:49334768 A/G cg20833759 chr3:49053208 WDR6;DALRD3 -0.38 -6.13 -0.32 2.48e-9 Menarche (age at onset); CRC cis rs6952808 1.000 rs4256490 chr7:1890764 G/A cg21782813 chr7:2030301 MAD1L1 0.45 7.44 0.38 8.57e-13 Bipolar disorder and schizophrenia; CRC cis rs1401999 0.546 rs4148593 chr3:183649870 A/G cg01324343 chr3:183735012 ABCC5 0.59 9.66 0.47 1.38e-19 Anterior chamber depth; CRC cis rs3857536 0.741 rs4710582 chr6:66939984 T/G cg07460842 chr6:66804631 NA -0.43 -5.81 -0.3 1.48e-8 Blood trace element (Cu levels); CRC cis rs644799 0.965 rs502521 chr11:95533557 T/A cg25622487 chr11:95524042 FAM76B;CEP57 0.75 11.82 0.55 4.16e-27 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs7809950 0.817 rs2204833 chr7:107283069 T/C cg23024343 chr7:107201750 COG5 0.66 8.86 0.44 5.28e-17 Coronary artery disease; CRC trans rs637571 0.522 rs493899 chr11:65747952 A/C cg17712092 chr4:129076599 LARP1B 0.67 11.1 0.52 1.59e-24 Eosinophil percentage of white cells; CRC cis rs853679 0.599 rs156743 chr6:27967089 T/C cg15845792 chr6:28175446 NA 0.7 6.44 0.33 4.26e-10 Depression; CRC trans rs11654801 0.891 rs1045215 chr17:20902959 G/C cg23759823 chr7:139672531 TBXAS1 -0.46 -6.49 -0.34 3.09e-10 Mosquito bite size; CRC cis rs4665809 0.590 rs10179959 chr2:26426403 G/A cg08067268 chr2:26466485 HADHB;HADHA -0.68 -8.67 -0.43 1.94e-16 Gut microbiome composition (summer); CRC cis rs10883723 0.810 rs10748824 chr10:104274466 T/C cg11453585 chr10:104263688 ACTR1A;SUFU 0.91 17.43 0.69 1.17e-48 Allergic disease (asthma, hay fever or eczema); CRC cis rs7811142 0.830 rs6965458 chr7:99973402 G/A cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.95 11.91 0.55 1.92e-27 Platelet count; CRC cis rs2576037 0.899 rs7233515 chr18:44585955 A/G cg23996704 chr18:44553084 KATNAL2 -0.3 -5.78 -0.3 1.71e-8 Personality dimensions; CRC cis rs3764563 1.000 rs4239612 chr19:15727442 A/G cg20725493 chr19:15740067 CYP4F8 -0.68 -6.43 -0.33 4.46e-10 Inflammatory biomarkers; CRC cis rs7737355 0.947 rs6875058 chr5:130882702 C/G cg06307176 chr5:131281290 NA 0.45 6.5 0.34 2.93e-10 Life satisfaction; CRC cis rs4713118 0.869 rs2056925 chr6:27690905 A/G cg02683197 chr6:28174875 NA 0.61 8.23 0.41 4.46e-15 Parkinson's disease; CRC trans rs57221529 0.713 rs56328416 chr5:591138 G/A cg11887960 chr12:57824829 NA 0.63 7.0 0.36 1.42e-11 Lung disease severity in cystic fibrosis; CRC cis rs9660992 0.542 rs17345153 chr1:205179997 A/G cg03948781 chr1:205179583 DSTYK 0.42 5.85 0.31 1.18e-8 Mean corpuscular volume;Mean platelet volume; CRC cis rs4843747 0.671 rs28465438 chr16:88103714 G/A cg03395651 chr16:88107091 BANP 0.6 7.72 0.39 1.37e-13 Menopause (age at onset); CRC cis rs12971120 0.947 rs34676212 chr18:72170006 A/G cg25817165 chr18:72167213 CNDP2 -0.66 -11.94 -0.55 1.47e-27 Refractive error; CRC cis rs3126085 0.935 rs11204939 chr1:152200942 G/C cg09127314 chr1:152161683 NA 0.49 6.38 0.33 5.91e-10 Atopic dermatitis; CRC cis rs28374715 0.681 rs28712264 chr15:41588797 T/C cg18705301 chr15:41695430 NDUFAF1 -1.12 -17.56 -0.7 3.5e-49 Ulcerative colitis; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg19791253 chr1:203595809 ATP2B4 0.44 6.23 0.32 1.39e-9 Response to antipsychotic treatment; CRC cis rs7811142 0.779 rs77370288 chr7:99947897 A/T cg00814883 chr7:100076585 TSC22D4 -0.7 -8.62 -0.43 2.91e-16 Platelet count; CRC cis rs6938 0.596 rs11072511 chr15:75159433 A/G cg14664628 chr15:75095509 CSK -0.65 -10.43 -0.5 3.34e-22 Breast cancer; CRC cis rs10982256 0.875 rs11789406 chr9:117246188 G/A cg13636371 chr9:117264095 DFNB31 0.4 7.56 0.38 4.09e-13 Bipolar disorder; CRC cis rs6693567 0.545 rs6664703 chr1:150459087 G/C cg15654264 chr1:150340011 RPRD2 0.4 5.91 0.31 8.38e-9 Migraine; CRC cis rs11122272 0.735 rs2247124 chr1:231493687 A/G cg06096015 chr1:231504339 EGLN1 0.38 5.67 0.3 3.06e-8 Hemoglobin concentration; CRC cis rs7107174 0.901 rs7937277 chr11:78114977 C/G cg02023728 chr11:77925099 USP35 0.39 6.2 0.32 1.71e-9 Testicular germ cell tumor; CRC trans rs10982213 0.830 rs2274163 chr9:117188714 C/T cg25312474 chr6:142468512 VTA1 0.4 6.03 0.32 4.36e-9 Interleukin-6 levels; CRC cis rs13191362 1.000 rs34637087 chr6:163004064 T/G cg21926612 chr6:163149169 PACRG;PARK2 0.8 11.15 0.52 1.08e-24 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs7945705 0.846 rs4929911 chr11:8816495 T/C cg21881798 chr11:8931708 C11orf17;ST5 0.5 7.59 0.39 3.29e-13 Hemoglobin concentration; CRC cis rs1707322 1.000 rs785469 chr1:46521091 C/T cg03146154 chr1:46216737 IPP -0.51 -7.1 -0.36 7.86e-12 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs1550582 1.000 rs1550582 chr8:135542084 A/G cg17885191 chr8:135476712 NA -0.71 -8.77 -0.44 1.01e-16 Educational attainment; CRC cis rs861020 1.000 rs595918 chr1:209966843 A/G cg09163369 chr1:210001066 C1orf107 0.54 7.13 0.37 6.27e-12 Orofacial clefts; CRC cis rs9435341 0.929 rs1762509 chr1:107592959 A/G cg11070056 chr1:107600091 PRMT6 -0.4 -5.62 -0.3 4e-8 Facial morphology (factor 21, depth of nasal alae); CRC trans rs9291683 0.609 rs4622999 chr4:10003395 C/G cg26043149 chr18:55253948 FECH 0.52 7.99 0.4 2.25e-14 Bone mineral density; CRC cis rs6121246 0.908 rs17093657 chr20:30428894 G/A cg13852791 chr20:30311386 BCL2L1 0.63 10.07 0.49 5.54e-21 Mean corpuscular hemoglobin; CRC cis rs4561483 0.801 rs33640 chr16:11986874 C/T cg08843971 chr16:11963173 GSPT1 -0.63 -9.79 -0.47 5e-20 Testicular germ cell tumor; CRC cis rs3733346 0.505 rs11734449 chr4:921733 C/A cg23939001 chr4:940644 TMEM175 0.7 12.7 0.57 2.42e-30 Sjögren's syndrome; CRC cis rs7615952 0.576 rs6804482 chr3:125815762 C/T cg02772935 chr3:125709198 NA -0.5 -5.83 -0.31 1.3e-8 Blood pressure (smoking interaction); CRC cis rs12594515 1.000 rs8027000 chr15:45987795 T/C cg19682013 chr15:45996608 NA 0.32 6.7 0.35 9.09e-11 Waist circumference;Weight; CRC cis rs6866344 0.601 rs4419608 chr5:178097049 C/T cg10224037 chr5:178157518 ZNF354A 0.58 7.4 0.38 1.14e-12 Neutrophil percentage of white cells; CRC cis rs875971 0.545 rs1065265 chr7:65841203 C/T cg05627663 chr7:65219948 SNORA22;CCT6P1 0.62 7.92 0.4 3.58e-14 Aortic root size; CRC cis rs2991971 0.934 rs2991974 chr1:46020654 A/G cg15605315 chr1:45957053 TESK2 0.43 6.62 0.34 1.48e-10 High light scatter reticulocyte count; CRC cis rs9467711 0.591 rs68149500 chr6:26111271 C/T cg08501292 chr6:25962987 TRIM38 0.83 7.89 0.4 4.46e-14 Autism spectrum disorder or schizophrenia; CRC cis rs760805 1.000 rs11249204 chr1:25261740 C/T cg22509179 chr1:25234806 RUNX3 0.58 8.91 0.44 3.66e-17 Allergic disease (asthma, hay fever or eczema); CRC cis rs780096 0.505 rs12475426 chr2:27599132 G/A cg22903471 chr2:27725779 GCKR -0.36 -5.89 -0.31 9.77e-9 Total body bone mineral density; CRC cis rs9902453 0.817 rs55758314 chr17:28173978 T/C cg26525008 chr17:28256777 EFCAB5;SSH2 0.58 8.63 0.43 2.65e-16 Coffee consumption (cups per day); CRC cis rs2739330 0.753 rs4822452 chr22:24254363 C/T cg04234412 chr22:24373322 LOC391322 -0.72 -11.92 -0.55 1.8e-27 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs2836754 1.000 rs11701117 chr21:40292512 C/T cg02119577 chr21:40195074 ETS2 -0.36 -6.13 -0.32 2.54e-9 Crohn's disease;Body mass index; CRC cis rs2228479 0.867 rs11646448 chr16:89966357 A/T cg06558623 chr16:89946397 TCF25 1.08 12.0 0.55 9.48e-28 Skin colour saturation; CRC cis rs9818758 0.607 rs13077498 chr3:49313978 C/T cg00383909 chr3:49044727 WDR6 1.16 10.88 0.51 9.66e-24 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; CRC trans rs11581859 0.950 rs59785571 chr1:99368627 C/A cg12183875 chr3:169587454 LRRC31 0.26 6.07 0.32 3.54e-9 Response to cognitive-behavioural therapy in anxiety disorder; CRC cis rs2797160 1.000 rs1739367 chr6:126004720 G/T cg05901451 chr6:126070800 HEY2 -0.4 -6.18 -0.32 1.93e-9 Endometrial cancer; CRC cis rs79349575 0.783 rs62075838 chr17:46996432 C/T cg00947319 chr17:47005597 UBE2Z -0.34 -5.87 -0.31 1.06e-8 Type 2 diabetes; CRC cis rs6142102 0.961 rs2284387 chr20:32644588 C/T cg08999081 chr20:33150536 PIGU 0.4 5.6 0.3 4.44e-8 Skin pigmentation; CRC trans rs1814175 0.935 rs11040465 chr11:49689323 C/T cg03929089 chr4:120376271 NA -0.93 -17.02 -0.68 5.01e-47 Height; CRC cis rs7737355 0.898 rs32109 chr5:131041590 C/T cg06307176 chr5:131281290 NA 0.42 6.15 0.32 2.2e-9 Life satisfaction; CRC cis rs6546550 0.935 rs11673826 chr2:70041033 G/A cg02498382 chr2:70120550 SNRNP27 -0.41 -6.56 -0.34 2.05e-10 Prevalent atrial fibrillation; CRC cis rs2251381 0.606 rs8129515 chr21:30520167 C/G cg24692254 chr21:30365293 RNF160 0.75 12.06 0.55 5.55e-28 Selective IgA deficiency; CRC cis rs40363 0.645 rs250633 chr16:3523002 C/T cg05754148 chr16:3507555 NAT15 0.47 6.61 0.34 1.52e-10 Tuberculosis; CRC cis rs478304 0.654 rs10896032 chr11:65459419 C/A cg27068330 chr11:65405492 SIPA1 -0.67 -9.92 -0.48 1.81e-20 Acne (severe); CRC cis rs11785400 1.000 rs4484678 chr8:143730796 A/G cg10596483 chr8:143751796 JRK 0.5 7.01 0.36 1.37e-11 Schizophrenia; CRC cis rs916888 0.647 rs199524 chr17:44848438 G/T cg01570182 chr17:44337453 NA -0.73 -9.18 -0.45 4.87e-18 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs1005277 0.541 rs1740741 chr10:38515334 C/T cg25517755 chr10:38738941 LOC399744 -0.41 -5.92 -0.31 8.23e-9 Extrinsic epigenetic age acceleration; CRC cis rs58904263 1 rs58904263 chr20:30401406 A/AG cg07809909 chr20:30433512 FOXS1 0.35 5.8 0.3 1.53e-8 Monocyte count; CRC cis rs1577917 1.000 rs6936048 chr6:86702608 C/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.52 -6.72 -0.35 8e-11 Response to antipsychotic treatment; CRC cis rs17767392 0.918 rs35094946 chr14:71752790 T/C cg13720639 chr14:72061746 SIPA1L1 -0.5 -6.34 -0.33 7.62e-10 Mitral valve prolapse; CRC cis rs10504229 0.683 rs11774585 chr8:58132685 G/A cg22535103 chr8:58192502 C8orf71 -0.7 -9.34 -0.46 1.47e-18 Developmental language disorder (linguistic errors); CRC trans rs61931739 0.500 rs7303318 chr12:34467789 T/C cg26384229 chr12:38710491 ALG10B 0.62 9.08 0.45 9.98e-18 Morning vs. evening chronotype; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg26731897 chr17:79633822 C17orf90;CCDC137 0.39 6.35 0.33 7.21e-10 Liver disease severity in Alagille syndrome; CRC cis rs4654899 0.772 rs61778530 chr1:21087363 G/C cg02927042 chr1:21476669 EIF4G3 -0.47 -7.27 -0.37 2.61e-12 Superior frontal gyrus grey matter volume; CRC cis rs9399135 0.967 rs9389261 chr6:135371148 C/G cg24558204 chr6:135376177 HBS1L 0.49 7.72 0.39 1.41e-13 Red blood cell count; CRC cis rs4972806 0.814 rs1446575 chr2:177047801 A/C cg03152288 chr2:177042942 NA 0.8 12.97 0.58 2.38e-31 IgG glycosylation; CRC cis rs10504229 0.683 rs58883273 chr8:58138275 A/G cg04204079 chr8:58130323 NA -0.45 -5.78 -0.3 1.71e-8 Developmental language disorder (linguistic errors); CRC cis rs1274963 0.601 rs811970 chr3:39196552 A/G cg02254461 chr3:39195904 CSRNP1 -0.5 -7.43 -0.38 9.45e-13 Chronic lymphocytic leukemia; CRC cis rs11997175 0.574 rs9642707 chr8:33645789 C/G cg04338863 chr8:33670619 NA 0.4 6.77 0.35 5.92e-11 Body mass index; CRC cis rs2067615 0.579 rs10861667 chr12:107194776 T/G cg13491945 chr12:107078410 RFX4 0.36 6.09 0.32 3.1e-9 Heart rate; CRC cis rs7786808 0.712 rs2335167 chr7:158213948 A/C cg17401720 chr7:158221031 PTPRN2 0.41 6.45 0.33 4.09e-10 Obesity-related traits; CRC cis rs708547 0.676 rs11133470 chr4:57864926 G/T cg25525207 chr4:57843836 C4orf14;POLR2B -0.48 -6.92 -0.36 2.41e-11 Response to bleomycin (chromatid breaks); CRC cis rs6952808 0.929 rs11761270 chr7:1923695 C/T cg04267008 chr7:1944627 MAD1L1 -0.84 -13.07 -0.58 9.91e-32 Bipolar disorder and schizophrenia; CRC cis rs4713118 0.662 rs464312 chr6:27967591 T/A cg03623178 chr6:28175578 NA 0.83 12.47 0.57 1.76e-29 Parkinson's disease; CRC cis rs4664293 0.632 rs7588230 chr2:160653720 C/T cg08347373 chr2:160653686 CD302 0.51 8.62 0.43 2.92e-16 Monocyte percentage of white cells; CRC cis rs2361718 0.501 rs11869566 chr17:78143248 T/C cg21238619 chr17:78079768 GAA -0.42 -6.87 -0.35 3.27e-11 Yeast infection; CRC cis rs4073582 0.595 rs801741 chr11:65917084 A/G cg16950941 chr11:66035639 RAB1B 0.71 12.3 0.56 7.37e-29 Gout; CRC cis rs7493 1.000 rs2299265 chr7:95048870 C/G cg20119798 chr7:94954144 PON1 -0.51 -6.48 -0.34 3.3e-10 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs10788264 0.504 rs4751886 chr10:124020396 T/C cg05683857 chr10:124030795 BTBD16 0.32 5.83 0.31 1.34e-8 Total body bone mineral density; CRC cis rs1552244 1.000 rs61052895 chr3:10147516 G/A cg18598329 chr3:10140678 FANCD2;C3orf24 -0.88 -11.86 -0.55 3.02e-27 Alzheimer's disease; CRC cis rs4664293 1.000 rs6432542 chr2:160480536 T/C cg08347373 chr2:160653686 CD302 -0.38 -6.28 -0.33 1.06e-9 Monocyte percentage of white cells; CRC cis rs4589502 0.800 rs2035150 chr15:67201794 A/C cg12317470 chr15:67143691 NA -0.54 -6.93 -0.36 2.25e-11 Lung cancer (smoking interaction); CRC trans rs16846053 0.579 rs57887363 chr2:162588720 C/T cg04551154 chr10:95462393 C10orf4 -0.73 -5.98 -0.31 5.86e-9 Blood osmolality (transformed sodium); CRC cis rs4974559 0.947 rs12639938 chr4:1343135 G/C cg02980000 chr4:1222292 CTBP1 0.73 8.38 0.42 1.52e-15 Systolic blood pressure; CRC cis rs877282 0.583 rs10904564 chr10:819459 C/G cg17470449 chr10:769945 NA 0.57 7.86 0.4 5.4e-14 Uric acid levels; CRC cis rs9467711 0.591 rs13220488 chr6:25896907 A/G cg12315302 chr6:26189340 HIST1H4D 0.8 6.44 0.33 4.14e-10 Autism spectrum disorder or schizophrenia; CRC cis rs3862030 0.503 rs6584506 chr10:104254428 T/C cg11453585 chr10:104263688 ACTR1A;SUFU 0.92 17.58 0.7 2.89e-49 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for body mass index; CRC cis rs2760061 0.819 rs964941 chr1:228193857 G/A cg02753203 chr1:228287806 NA 0.69 10.74 0.51 2.99e-23 Diastolic blood pressure; CRC cis rs4423214 0.592 rs10898193 chr11:71197083 A/G cg05163923 chr11:71159392 DHCR7 0.52 5.63 0.3 3.82e-8 Vitamin D levels; CRC cis rs72634258 0.945 rs28624 chr1:8084355 G/T cg26816564 chr1:7831052 VAMP3 -0.46 -5.63 -0.3 3.86e-8 Inflammatory bowel disease; CRC cis rs3820068 0.580 rs7556473 chr1:15996858 C/T cg27534772 chr1:16042836 PLEKHM2 -0.54 -10.56 -0.5 1.21e-22 Systolic blood pressure; CRC cis rs1816752 0.905 rs4770680 chr13:25015248 T/C cg02811702 chr13:24901961 NA 0.48 6.63 0.34 1.4e-10 Obesity-related traits; CRC cis rs763121 0.853 rs6001185 chr22:39052155 G/A cg06022373 chr22:39101656 GTPBP1 0.78 12.35 0.56 4.64e-29 Menopause (age at onset); CRC cis rs5769765 0.773 rs58375955 chr22:50312630 A/G cg08270630 chr22:50330655 NA -0.4 -5.61 -0.3 4.4e-8 Schizophrenia; CRC cis rs853679 0.723 rs1736904 chr6:28219270 G/A cg15786705 chr6:28176104 NA 0.59 6.99 0.36 1.58e-11 Depression; CRC cis rs2180341 0.538 rs4392733 chr6:127712603 T/C cg24812749 chr6:127587940 RNF146 0.49 7.19 0.37 4.43e-12 Breast cancer; CRC cis rs9649213 0.593 rs6465667 chr7:97957885 G/A cg21770322 chr7:97807741 LMTK2 0.52 8.54 0.43 5.11e-16 Prostate cancer (SNP x SNP interaction); CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg17804987 chr3:50654788 MAPKAPK3 0.44 6.1 0.32 2.95e-9 Anxiety disorder; CRC cis rs995000 0.931 rs630144 chr1:62918864 A/G cg19896129 chr1:63156450 NA 0.44 6.78 0.35 5.59e-11 Triglyceride levels; CRC cis rs6840360 0.967 rs4383600 chr4:152694383 T/C cg09659197 chr4:152720779 NA 0.52 11.39 0.53 1.51e-25 Intelligence (multi-trait analysis); CRC cis rs10791323 0.511 rs4937837 chr11:133731134 T/C cg06766960 chr11:133703094 NA -0.38 -6.29 -0.33 1.01e-9 Childhood ear infection; CRC trans rs5756813 0.870 rs5756812 chr22:38173113 C/T cg19894588 chr14:64061835 NA 0.61 8.65 0.43 2.32e-16 Optic cup area;Vertical cup-disc ratio; CRC cis rs6952808 0.609 rs10274300 chr7:1950405 C/G cg02951883 chr7:2050386 MAD1L1 -0.53 -8.69 -0.43 1.76e-16 Bipolar disorder and schizophrenia; CRC cis rs6459804 1.000 rs6459804 chr7:157510195 C/T cg05731713 chr7:157510257 PTPRN2 0.45 7.65 0.39 2.26e-13 Bipolar disorder and schizophrenia; CRC cis rs7666738 0.830 rs17027216 chr4:99009152 G/C cg17366294 chr4:99064904 C4orf37 0.44 7.39 0.38 1.19e-12 Colonoscopy-negative controls vs population controls; CRC cis rs4561483 0.583 rs11647580 chr16:11957609 G/C cg08843971 chr16:11963173 GSPT1 0.52 7.76 0.39 1.1e-13 Testicular germ cell tumor; CRC cis rs1862618 0.671 rs2591958 chr5:56239369 C/G cg03609598 chr5:56110824 MAP3K1 0.58 7.95 0.4 2.98e-14 Initial pursuit acceleration; CRC cis rs4728302 0.934 rs2971963 chr7:133641505 A/G cg03336402 chr7:133662267 EXOC4 0.47 7.16 0.37 5.19e-12 Intelligence;Intelligence (multi-trait analysis); CRC cis rs1030268 0.505 rs80305547 chr7:133259400 A/G cg10665199 chr7:133106180 EXOC4 0.66 7.88 0.4 4.73e-14 Intelligence (multi-trait analysis); CRC cis rs7737355 0.947 rs9885286 chr5:130883270 C/T cg06307176 chr5:131281290 NA 0.42 6.13 0.32 2.54e-9 Life satisfaction; CRC cis rs9818758 0.607 rs11706189 chr3:49210833 C/A cg07636037 chr3:49044803 WDR6 -0.66 -5.7 -0.3 2.69e-8 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; CRC trans rs7395662 0.624 rs11040162 chr11:48959991 C/T cg21153622 chr11:89784906 NA 0.47 7.46 0.38 7.87e-13 HDL cholesterol; CRC cis rs6502050 0.835 rs55679819 chr17:80105450 C/T cg22110888 chr17:80059540 CCDC57 0.4 6.35 0.33 7.32e-10 Life satisfaction; CRC cis rs1008375 1.000 rs3933453 chr4:17636319 A/C cg04450456 chr4:17643702 FAM184B 0.35 5.67 0.3 3.12e-8 Parasitemia in Tripanosoma cruzi seropositivity; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg12302829 chr15:63341214 TPM1 0.42 6.41 0.33 5.1e-10 Liver disease severity in Alagille syndrome; CRC trans rs7613875 0.578 rs2526749 chr3:50076734 A/G cg21665057 chr3:196295764 WDR53;FBXO45 -0.47 -7.08 -0.36 8.67e-12 Body mass index; CRC cis rs231513 0.911 rs231511 chr17:41966335 T/C cg16892393 chr17:41919603 NA -0.53 -5.78 -0.3 1.77e-8 Cognitive function; CRC cis rs853679 0.567 rs3799499 chr6:28354250 G/T cg21251018 chr6:28226885 NKAPL 0.42 6.11 0.32 2.75e-9 Depression; CRC cis rs1865760 0.551 rs9461230 chr6:26019240 G/C cg17691542 chr6:26056736 HIST1H1C 0.56 8.62 0.43 2.79e-16 Height; CRC cis rs1552244 0.515 rs7613004 chr3:9999913 A/C cg16606324 chr3:10149918 C3orf24 0.45 6.8 0.35 4.87e-11 Alzheimer's disease; CRC cis rs9399135 1.000 rs1014021 chr6:135334600 C/T cg24558204 chr6:135376177 HBS1L -0.5 -7.85 -0.4 5.75e-14 Red blood cell count; CRC cis rs6988985 0.560 rs7826809 chr8:143925609 C/T cg10324643 chr8:143916377 GML 0.38 6.3 0.33 9.63e-10 Plasma androstenedione levels in resected early stage-receptor positive breast cancer; CRC cis rs7683537 0.887 rs4540092 chr4:185633546 A/G cg04058563 chr4:185651563 MLF1IP 0.73 9.38 0.46 1.13e-18 Systemic lupus erythematosus; CRC cis rs2011503 0.943 rs8100927 chr19:19643636 C/G cg11584989 chr19:19387371 SF4 0.59 6.53 0.34 2.48e-10 Bipolar disorder; CRC cis rs7666738 0.830 rs28497822 chr4:98906873 C/T cg17366294 chr4:99064904 C4orf37 0.41 6.73 0.35 7.45e-11 Colonoscopy-negative controls vs population controls; CRC cis rs9674544 0.740 rs11870560 chr17:47114033 T/C cg10950924 chr17:47092072 IGF2BP1 -0.37 -6.03 -0.32 4.47e-9 Primary tooth development (time to first tooth eruption);Primary tooth development (number of teeth); CRC cis rs7799006 0.527 rs73039284 chr7:2221583 C/G cg21782813 chr7:2030301 MAD1L1 0.41 6.61 0.34 1.55e-10 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC trans rs11039798 1.000 rs6485848 chr11:48541517 G/T cg03929089 chr4:120376271 NA 0.62 6.01 0.31 4.91e-9 Axial length; CRC cis rs11155671 0.530 rs2342770 chr6:150216685 C/T cg13206674 chr6:150067644 NUP43 0.5 6.97 0.36 1.73e-11 Testicular germ cell tumor; CRC cis rs2777491 0.574 rs2730056 chr15:41735785 A/G cg18705301 chr15:41695430 NDUFAF1 -1.13 -19.38 -0.73 2.35e-56 Ulcerative colitis; CRC cis rs3768617 0.510 rs10797846 chr1:183087485 A/T ch.1.3577855R chr1:183094577 LAMC1 0.89 15.86 0.66 1.84e-42 Fuchs's corneal dystrophy; CRC cis rs870825 0.616 rs28444118 chr4:185621692 T/C cg04058563 chr4:185651563 MLF1IP 0.72 9.38 0.46 1.12e-18 Blood protein levels; CRC cis rs7769051 0.522 rs6927991 chr6:133113888 T/G cg22852734 chr6:133119734 C6orf192 1.04 7.73 0.39 1.32e-13 Type 2 diabetes nephropathy; CRC cis rs6952808 0.689 rs12670737 chr7:2046830 C/T cg04267008 chr7:1944627 MAD1L1 -0.71 -10.22 -0.49 1.76e-21 Bipolar disorder and schizophrenia; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg24677732 chr10:6019526 IL15RA 0.44 6.02 0.31 4.74e-9 Anxiety disorder; CRC cis rs8076336 1 rs8076336 chr17:18212614 A/C cg16794390 chr17:18148240 FLII 0.31 5.88 0.31 9.84e-9 Parental longevity (combined parental age at death); CRC cis rs1552244 0.554 rs59465469 chr3:9990800 G/C cg08888203 chr3:10149979 C3orf24 0.45 7.19 0.37 4.45e-12 Alzheimer's disease; CRC trans rs7618501 1.000 rs60205400 chr3:49800272 C/T cg21665057 chr3:196295764 WDR53;FBXO45 0.86 15.79 0.66 3.5e-42 Intelligence (multi-trait analysis); CRC trans rs2303319 0.504 rs72877343 chr2:162607487 A/C cg25193742 chr10:104614220 C10orf32 -0.77 -6.51 -0.34 2.87e-10 Cognitive function; CRC cis rs6831352 0.879 rs2602879 chr4:100040652 G/A cg13256891 chr4:100009986 ADH5 0.63 8.54 0.43 4.99e-16 Alcohol dependence; CRC cis rs7178572 0.889 rs7170877 chr15:77832019 C/G cg22256960 chr15:77711686 NA -0.67 -9.72 -0.47 8.78e-20 Type 2 diabetes; CRC cis rs2197308 0.606 rs2218397 chr12:38278307 C/T cg26384229 chr12:38710491 ALG10B -0.49 -7.08 -0.36 8.71e-12 Morning vs. evening chronotype; CRC trans rs3733585 0.673 rs10018204 chr4:9964570 C/T cg26043149 chr18:55253948 FECH -0.5 -7.62 -0.39 2.81e-13 Cleft plate (environmental tobacco smoke interaction); CRC cis rs7086627 0.515 rs10887900 chr10:82210265 A/G cg00277334 chr10:82204260 NA -0.82 -16.45 -0.67 8.68e-45 Post bronchodilator FEV1; CRC cis rs597539 0.552 rs6591360 chr11:68718669 G/T cg06112835 chr11:68658793 MRPL21 0.38 6.14 0.32 2.34e-9 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg02835499 chr17:46178918 CBX1 0.4 6.59 0.34 1.75e-10 Liver disease severity in Alagille syndrome; CRC cis rs6740322 0.643 rs13390381 chr2:43534414 C/A cg06169590 chr2:43455088 ZFP36L2;LOC100129726 -0.48 -5.83 -0.31 1.36e-8 Coronary artery disease; CRC cis rs10504229 1.000 rs67895971 chr8:58177994 A/G cg05313129 chr8:58192883 C8orf71 -0.47 -6.99 -0.36 1.49e-11 Developmental language disorder (linguistic errors); CRC cis rs10504229 0.724 rs72650827 chr8:58126884 A/T cg22535103 chr8:58192502 C8orf71 -0.7 -9.34 -0.46 1.47e-18 Developmental language disorder (linguistic errors); CRC cis rs6570726 0.791 rs11155433 chr6:145907831 A/G cg23711669 chr6:146136114 FBXO30 -0.71 -12.12 -0.56 3.46e-28 Lobe attachment (rater-scored or self-reported); CRC cis rs1008375 1.000 rs3815413 chr4:17654648 T/C cg02297831 chr4:17616191 MED28 0.5 6.66 0.34 1.12e-10 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs853679 0.517 rs9393893 chr6:28109262 T/C cg02683197 chr6:28174875 NA 0.87 10.73 0.51 3.25e-23 Depression; CRC trans rs1005277 0.579 rs176886 chr10:38403974 C/T cg11292332 chr7:45801988 SEPT13 -0.35 -6.25 -0.33 1.24e-9 Extrinsic epigenetic age acceleration; CRC cis rs370915 0.578 rs28627789 chr4:187788774 T/C cg12892747 chr4:187813459 NA -0.55 -7.89 -0.4 4.63e-14 Gout; CRC cis rs798554 0.757 rs1182177 chr7:2874540 C/T cg19346786 chr7:2764209 NA -0.42 -7.07 -0.36 9.18e-12 Height; CRC cis rs4713118 0.955 rs9468206 chr6:27690453 G/T cg26587870 chr6:27730563 NA -0.43 -6.36 -0.33 6.83e-10 Parkinson's disease; CRC cis rs3091242 0.933 rs34933589 chr1:25788198 T/C cg20684491 chr1:25596433 NA -0.43 -7.43 -0.38 9.68e-13 Erythrocyte sedimentation rate; CRC trans rs453301 0.686 rs1045527 chr8:8890041 A/G cg16141378 chr3:129829833 LOC729375 0.42 6.3 0.33 9.66e-10 Joint mobility (Beighton score); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg22713327 chr12:120703336 PXN 0.36 6.15 0.32 2.19e-9 Liver disease severity in Alagille syndrome; CRC cis rs7215564 0.908 rs35584560 chr17:78668256 G/A cg09596252 chr17:78655493 RPTOR 0.55 6.09 0.32 3.19e-9 Myopia (pathological); CRC cis rs938554 0.779 rs11735831 chr4:9951591 G/A cg00071950 chr4:10020882 SLC2A9 -0.44 -5.91 -0.31 8.72e-9 Blood metabolite levels; CRC cis rs9875589 0.957 rs66716710 chr3:13938728 A/G cg14375111 chr3:14165186 TMEM43;CHCHD4 -0.4 -5.83 -0.31 1.31e-8 Ovarian reserve; CRC cis rs738322 1.000 rs738322 chr22:38569006 A/G cg25457927 chr22:38595422 NA -0.37 -7.66 -0.39 2.04e-13 Cutaneous nevi; CRC cis rs1997103 1.000 rs10270618 chr7:55396712 T/A cg17469321 chr7:55412551 NA 0.74 11.38 0.53 1.54e-25 QRS interval (sulfonylurea treatment interaction); CRC cis rs9733 0.818 rs7520022 chr1:150659173 C/G cg18016565 chr1:150552671 MCL1 -0.41 -6.15 -0.32 2.25e-9 Tonsillectomy; CRC cis rs5750830 0.649 rs7949 chr22:39827553 G/A cg11247378 chr22:39784982 NA -0.48 -9.35 -0.46 1.37e-18 Intelligence (multi-trait analysis); CRC cis rs2274273 0.905 rs2147961 chr14:55585381 T/C cg23234261 chr14:55582407 NA -0.3 -5.94 -0.31 7.18e-9 Protein biomarker; CRC cis rs10512697 0.655 rs35209468 chr5:3473582 C/T cg19473799 chr5:3511975 NA -0.83 -6.35 -0.33 7.32e-10 Immune response to smallpox vaccine (IL-6); CRC cis rs4363385 0.667 rs454186 chr1:153049149 C/T cg25856811 chr1:152973957 SPRR3 -0.24 -6.58 -0.34 1.86e-10 Inflammatory skin disease; CRC cis rs35110281 0.805 rs2838318 chr21:44991825 G/A cg04455712 chr21:45112962 RRP1B 0.41 7.94 0.4 3.17e-14 Mean corpuscular volume; CRC cis rs524281 0.682 rs4483592 chr11:65990439 C/T cg16950941 chr11:66035639 RAB1B -0.7 -8.05 -0.41 1.53e-14 Electroencephalogram traits; CRC cis rs7223966 0.515 rs2727315 chr17:61961458 C/T cg23903597 chr17:61704154 MAP3K3 -0.43 -5.7 -0.3 2.72e-8 Hip circumference adjusted for BMI;Body mass index; CRC cis rs780096 0.526 rs72819536 chr2:27682850 G/T cg27432699 chr2:27873401 GPN1 -0.62 -9.48 -0.46 5.39e-19 Total body bone mineral density; CRC trans rs1455244 0.700 rs7229302 chr18:11508904 G/T cg13357455 chr5:134240501 PCBD2 0.38 6.1 0.32 3.05e-9 Schizophrenia; CRC cis rs9430161 0.579 rs11121667 chr1:11038476 C/T cg02454025 chr1:11042201 C1orf127 0.87 14.17 0.62 6.71e-36 Ewing sarcoma; CRC cis rs7772486 0.597 rs2246132 chr6:146182515 C/G cg23711669 chr6:146136114 FBXO30 0.66 9.66 0.47 1.35e-19 Lobe attachment (rater-scored or self-reported); CRC cis rs9916302 0.571 rs28799952 chr17:37533056 C/T cg15445000 chr17:37608096 MED1 -0.35 -6.23 -0.32 1.43e-9 Glomerular filtration rate (creatinine); CRC cis rs2067615 0.579 rs6539283 chr12:107222989 C/T cg13491945 chr12:107078410 RFX4 0.34 5.85 0.31 1.2e-8 Heart rate; CRC cis rs2727020 0.521 rs10839285 chr11:49496852 T/G cg27395922 chr11:50257633 LOC441601 0.39 6.6 0.34 1.61e-10 Coronary artery disease; CRC cis rs875971 0.862 rs7786892 chr7:65628876 G/A cg18876405 chr7:65276391 NA -0.52 -8.63 -0.43 2.59e-16 Aortic root size; CRC cis rs6963495 0.818 rs55740553 chr7:105159551 A/G cg02135003 chr7:105160482 PUS7 -0.9 -12.2 -0.56 1.71e-28 Bipolar disorder (body mass index interaction); CRC cis rs911555 0.755 rs8016676 chr14:103904842 C/A cg12935359 chr14:103987150 CKB 0.56 9.13 0.45 7.33e-18 Intelligence (multi-trait analysis); CRC cis rs7769051 1.000 rs12204027 chr6:133122831 A/G cg22852734 chr6:133119734 C6orf192 1.05 12.84 0.58 7.03e-31 Type 2 diabetes nephropathy; CRC cis rs17270561 0.636 rs9379782 chr6:25715023 G/A cg16482183 chr6:26056742 HIST1H1C 0.76 9.5 0.46 4.61e-19 Iron status biomarkers; CRC cis rs9549260 0.591 rs9577108 chr13:41271764 G/A cg21288729 chr13:41239152 FOXO1 0.45 6.97 0.36 1.78e-11 Red blood cell count; CRC trans rs61931739 0.500 rs7979482 chr12:34542877 C/A cg26384229 chr12:38710491 ALG10B 0.67 8.78 0.44 8.82e-17 Morning vs. evening chronotype; CRC cis rs7208859 0.673 rs423151 chr17:28952286 A/G cg14008862 chr17:28927542 LRRC37B2 0.49 6.17 0.32 1.96e-9 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs11148252 0.967 rs11618716 chr13:53046836 A/G cg12458913 chr13:53173898 NA -0.55 -8.87 -0.44 4.78e-17 Lewy body disease; CRC cis rs8177179 0.967 rs9869311 chr3:133451613 C/T cg24879335 chr3:133465180 TF 0.49 9.67 0.47 1.26e-19 Iron status biomarkers (transferrin levels); CRC cis rs11997175 0.574 rs12156280 chr8:33650277 C/T ch.8.33884649F chr8:33765107 NA 0.47 7.56 0.38 4.15e-13 Body mass index; CRC cis rs2033711 0.837 rs3764535 chr19:58929052 G/A cg00825309 chr19:58991885 ZNF446 -0.5 -7.39 -0.38 1.2e-12 Uric acid clearance; CRC cis rs6582630 0.502 rs11182760 chr12:38606273 A/T cg26384229 chr12:38710491 ALG10B 0.69 9.19 0.45 4.61e-18 Drug-induced liver injury (flucloxacillin); CRC cis rs13217239 0.608 rs6930508 chr6:27053142 T/C cg12292205 chr6:26970375 C6orf41 -0.51 -8.46 -0.42 9.08e-16 Schizophrenia; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg20430124 chr2:9954241 NA 0.4 6.05 0.32 3.93e-9 Intelligence (multi-trait analysis); CRC cis rs6424115 0.965 rs2502986 chr1:24135292 G/T cg15997130 chr1:24165203 NA 0.72 11.48 0.53 6.74e-26 Immature fraction of reticulocytes; CRC cis rs2032447 0.869 rs199752 chr6:26012875 C/T cg03264133 chr6:25882463 NA -0.54 -7.32 -0.37 1.9e-12 Intelligence (multi-trait analysis); CRC cis rs10504229 0.683 rs949856 chr8:58144496 G/A cg02725872 chr8:58115012 NA -0.63 -11.21 -0.53 6.31e-25 Developmental language disorder (linguistic errors); CRC cis rs7769051 0.522 rs73554461 chr6:133139087 T/G cg07930552 chr6:133119739 C6orf192 0.74 6.06 0.32 3.68e-9 Type 2 diabetes nephropathy; CRC cis rs2046867 0.818 rs1502757 chr3:72864161 C/T cg25664220 chr3:72788482 NA -0.47 -6.74 -0.35 6.9e-11 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; CRC cis rs4662945 0.525 rs28625431 chr2:130303333 A/G cg05903289 chr2:130345205 NA -0.36 -6.82 -0.35 4.49e-11 Response to cytidine analogues (gemcitabine); CRC cis rs2180341 0.960 rs6900074 chr6:127685893 A/G cg24812749 chr6:127587940 RNF146 0.92 13.19 0.59 3.44e-32 Breast cancer; CRC cis rs422249 0.512 rs174561 chr11:61582708 T/C cg00603274 chr11:61596626 FADS2 -0.49 -6.8 -0.35 5.04e-11 Trans fatty acid levels; CRC cis rs9611565 0.921 rs6002333 chr22:41719469 C/T cg06634786 chr22:41940651 POLR3H -0.53 -6.57 -0.34 1.91e-10 Vitiligo; CRC cis rs2404602 0.583 rs3759853 chr15:76587777 C/T cg03037974 chr15:76606532 NA 0.82 16.48 0.67 6.46e-45 Blood metabolite levels; CRC cis rs10782582 0.609 rs1630587 chr1:76399787 T/C cg10523679 chr1:76189770 ACADM -0.39 -5.65 -0.3 3.43e-8 Daytime sleep phenotypes; CRC cis rs6754459 0.502 rs34759180 chr2:3707394 C/T cg00999904 chr2:3704751 ALLC -0.96 -11.37 -0.53 1.75e-25 Response to inhaled corticosteroid treatment in asthma (change in FEV1); CRC cis rs10504229 1.000 rs34616626 chr8:58184650 C/T cg02725872 chr8:58115012 NA -0.38 -6.43 -0.33 4.44e-10 Developmental language disorder (linguistic errors); CRC cis rs2204008 0.818 rs7313608 chr12:38383428 C/A cg13010199 chr12:38710504 ALG10B -0.46 -6.59 -0.34 1.74e-10 Bladder cancer; CRC cis rs1005277 0.579 rs2472178 chr10:38384750 T/C cg25427524 chr10:38739819 LOC399744 -0.77 -14.06 -0.61 1.68e-35 Extrinsic epigenetic age acceleration; CRC cis rs8077889 1.000 rs113919636 chr17:41877740 A/C cg26893861 chr17:41843967 DUSP3 0.88 11.59 0.54 2.78e-26 Triglycerides; CRC cis rs9325144 0.625 rs12227353 chr12:38734542 C/T cg13010199 chr12:38710504 ALG10B -0.43 -6.14 -0.32 2.42e-9 Morning vs. evening chronotype; CRC cis rs17641971 0.684 rs7005693 chr8:49987965 A/C cg00325661 chr8:49890786 NA 0.37 6.22 0.32 1.51e-9 Blood metabolite levels; CRC cis rs9584850 0.834 rs745638 chr13:99119307 C/G cg07423050 chr13:99094983 FARP1 -0.45 -6.54 -0.34 2.37e-10 Neuroticism; CRC cis rs7119 0.717 rs12910513 chr15:77817258 C/T cg27398640 chr15:77910606 LINGO1 -0.43 -7.47 -0.38 7.13e-13 Type 2 diabetes; CRC cis rs8180040 0.739 rs11719306 chr3:47184182 G/A cg02527881 chr3:46936655 PTH1R -0.38 -7.01 -0.36 1.39e-11 Colorectal cancer; CRC cis rs10504229 0.728 rs17215621 chr8:58152706 C/A cg24829409 chr8:58192753 C8orf71 -0.58 -7.96 -0.4 2.86e-14 Developmental language disorder (linguistic errors); CRC cis rs6570726 0.791 rs418701 chr6:145889992 C/T cg23711669 chr6:146136114 FBXO30 0.69 11.52 0.54 4.94e-26 Lobe attachment (rater-scored or self-reported); CRC cis rs2717559 0.542 rs2717586 chr8:143897882 C/T cg05569086 chr8:143859399 LYNX1 0.65 11.32 0.53 2.55e-25 Urinary tract infection frequency; CRC cis rs7727544 0.570 rs7701237 chr5:131534381 C/T cg18758796 chr5:131593413 PDLIM4 0.33 5.65 0.3 3.44e-8 Blood metabolite levels; CRC trans rs61101201 1.000 rs1223120 chr11:31465050 T/G cg11934170 chr4:155254326 DCHS2 -0.41 -5.96 -0.31 6.41e-9 Optic disc area; CRC cis rs4601821 1.000 rs6589375 chr11:113255111 C/A cg14159747 chr11:113255604 NA 0.51 9.61 0.47 1.92e-19 Alcoholic chronic pancreatitis; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg02741808 chr17:73780792 UNK 0.44 6.05 0.32 3.95e-9 Response to antipsychotic treatment; CRC cis rs1451375 0.617 rs1376524 chr7:50563582 G/A cg14593290 chr7:50529359 DDC -0.64 -8.52 -0.42 6e-16 Malaria; CRC cis rs3823572 0.525 rs6946805 chr7:133714482 T/C cg03336402 chr7:133662267 EXOC4 -0.64 -9.18 -0.45 4.92e-18 Intelligence (multi-trait analysis); CRC cis rs7635838 0.687 rs9849485 chr3:11395741 G/A cg00170343 chr3:11313890 ATG7 0.48 7.36 0.38 1.52e-12 HDL cholesterol; CRC cis rs6952808 0.792 rs2056481 chr7:1955435 A/G cg04267008 chr7:1944627 MAD1L1 -0.84 -12.61 -0.57 5.23e-30 Bipolar disorder and schizophrenia; CRC cis rs875971 0.545 rs10950025 chr7:65623933 G/A cg03233332 chr7:66118400 NA -0.45 -6.22 -0.32 1.49e-9 Aortic root size; CRC cis rs875971 0.830 rs7799834 chr7:65880694 A/C cg12463550 chr7:65579703 CRCP 0.48 6.96 0.36 1.89e-11 Aortic root size; CRC cis rs694739 1.000 rs646153 chr11:64089588 C/T cg23796481 chr11:64053134 BAD;GPR137 0.59 8.81 0.44 7.45e-17 Alopecia areata;Crohn's disease;Psoriasis vulgaris; CRC cis rs12325245 0.536 rs17821549 chr16:58554780 C/T cg26666090 chr16:58549219 SETD6 0.97 6.47 0.34 3.54e-10 Schizophrenia; CRC trans rs9858542 0.953 rs11922013 chr3:49458355 G/C cg21665057 chr3:196295764 WDR53;FBXO45 -0.64 -8.74 -0.43 1.2e-16 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC trans rs2303319 0.504 rs62187655 chr2:162487440 C/G cg13490827 chr1:46269305 MAST2 -0.72 -6.21 -0.32 1.6e-9 Cognitive function; CRC cis rs9325144 0.555 rs4550281 chr12:38689937 A/G cg13010199 chr12:38710504 ALG10B 0.44 6.32 0.33 8.69e-10 Morning vs. evening chronotype; CRC trans rs3749237 0.964 rs13084243 chr3:49821878 G/C cg21659725 chr3:3221576 CRBN 0.54 7.34 0.38 1.65e-12 Resting heart rate; CRC trans rs2235573 0.551 rs84770 chr22:38390128 T/G cg19894588 chr14:64061835 NA 0.53 7.48 0.38 7.02e-13 Glioblastoma;Glioma; CRC cis rs6502050 0.871 rs6502051 chr17:80059332 A/C cg22110888 chr17:80059540 CCDC57 -0.44 -7.01 -0.36 1.36e-11 Life satisfaction; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg03501777 chr10:45869613 ALOX5 0.38 5.99 0.31 5.39e-9 Liver disease severity in Alagille syndrome; CRC cis rs4908768 0.539 rs1061039 chr1:8642588 T/C cg20416874 chr1:8611966 RERE -0.4 -5.68 -0.3 3e-8 Neuroticism (multi-trait analysis);Subjective well-being (multi-trait analysis); CRC cis rs6952808 0.789 rs35729895 chr7:1885069 C/T cg20295408 chr7:1910781 MAD1L1 -0.44 -6.37 -0.33 6.41e-10 Bipolar disorder and schizophrenia; CRC cis rs243505 0.691 rs243484 chr7:148448655 G/T cg09806900 chr7:148480153 CUL1 -0.57 -7.15 -0.37 5.56e-12 Inflammatory bowel disease;Crohn's disease; CRC cis rs13315871 0.929 rs13077539 chr3:58267846 T/C cg20936604 chr3:58311152 NA -0.59 -5.66 -0.3 3.23e-8 Cholesterol, total; CRC cis rs6964587 1.000 rs13231820 chr7:91663529 A/G cg17063962 chr7:91808500 NA 0.76 12.24 0.56 1.25e-28 Breast cancer; CRC cis rs9287719 0.649 rs2884232 chr2:10719679 C/A cg00105475 chr2:10696890 NA 0.45 7.06 0.36 9.97e-12 Prostate cancer; CRC cis rs6681460 0.898 rs1032634 chr1:67195192 C/G cg02459107 chr1:67143332 SGIP1 -0.36 -6.05 -0.32 3.9e-9 Presence of antiphospholipid antibodies; CRC cis rs10751667 0.643 rs11246344 chr11:933783 A/C cg01483505 chr11:975446 AP2A2 0.43 6.82 0.35 4.37e-11 Alzheimer's disease (late onset); CRC cis rs13108904 0.935 rs13148614 chr4:1248357 G/C cg00684032 chr4:1343700 KIAA1530 0.4 5.84 0.31 1.24e-8 Obesity-related traits; CRC cis rs10504229 0.679 rs16920056 chr8:58106218 C/A cg22535103 chr8:58192502 C8orf71 -0.69 -8.8 -0.44 7.79e-17 Developmental language disorder (linguistic errors); CRC trans rs1814175 0.669 rs11040473 chr11:49703813 C/T cg15704280 chr7:45808275 SEPT13 -0.76 -12.46 -0.57 1.89e-29 Height; CRC cis rs1451375 0.959 rs17133878 chr7:50620927 T/C cg18232548 chr7:50535776 DDC 0.44 6.5 0.34 2.95e-10 Malaria; CRC cis rs6088580 0.634 rs11700221 chr20:32940320 T/C cg24642439 chr20:33292090 TP53INP2 -0.4 -6.67 -0.35 1.06e-10 Glomerular filtration rate (creatinine); CRC trans rs963731 0.649 rs3765058 chr2:39189636 A/G cg13401531 chr11:70333281 SHANK2 -0.74 -6.35 -0.33 7.11e-10 Corticobasal degeneration; CRC cis rs1023500 0.551 rs2859438 chr22:42466980 A/T cg25452165 chr22:42524984 CYP2D6 0.4 6.04 0.32 4.11e-9 Schizophrenia; CRC trans rs1005277 0.603 rs1998062 chr10:38457652 G/C cg17830980 chr10:43048298 ZNF37B -0.59 -9.89 -0.48 2.27e-20 Extrinsic epigenetic age acceleration; CRC trans rs11098499 0.754 rs1980025 chr4:120252806 A/G cg25214090 chr10:38739885 LOC399744 -0.52 -8.2 -0.41 5.31e-15 Corneal astigmatism; CRC cis rs2839186 0.500 rs13052701 chr21:47660045 A/T cg26721908 chr21:47610096 LSS -0.46 -6.67 -0.34 1.11e-10 Testicular germ cell tumor; CRC cis rs870825 0.616 rs35533356 chr4:185639134 A/G cg04058563 chr4:185651563 MLF1IP 0.74 9.66 0.47 1.34e-19 Blood protein levels; CRC cis rs4662945 0.762 rs2406822 chr2:130218178 C/T cg05962382 chr2:130345044 NA -0.34 -5.77 -0.3 1.86e-8 Response to cytidine analogues (gemcitabine); CRC cis rs12497850 0.864 rs6779394 chr3:49157771 G/A cg07636037 chr3:49044803 WDR6 0.98 15.46 0.65 6.74e-41 Parkinson's disease; CRC cis rs11252926 0.574 rs4881313 chr10:487973 C/T cg16386425 chr10:429943 DIP2C 0.43 6.4 0.33 5.45e-10 Psychosis in Alzheimer's disease; CRC trans rs208520 1.000 rs12191403 chr6:66978137 C/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.88 10.79 0.51 1.94e-23 Exhaled nitric oxide output; CRC cis rs7208859 0.623 rs78071511 chr17:29128154 C/T cg01831904 chr17:28903510 LRRC37B2 -0.62 -6.41 -0.33 5.13e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs7043114 0.525 rs7023004 chr9:95098712 A/G cg14631576 chr9:95140430 CENPP -0.31 -5.89 -0.31 9.7e-9 Height; CRC cis rs8014204 0.762 rs10139018 chr14:75274292 T/C cg03030879 chr14:75389066 RPS6KL1 -0.41 -6.41 -0.33 5.04e-10 Caffeine consumption; CRC cis rs9916302 0.851 rs2338795 chr17:37399364 T/G cg15445000 chr17:37608096 MED1 0.4 8.65 0.43 2.37e-16 Glomerular filtration rate (creatinine); CRC cis rs12142240 0.698 rs72677593 chr1:46824363 T/C cg00530320 chr1:46809349 NSUN4 0.59 8.03 0.41 1.69e-14 Menopause (age at onset); CRC cis rs11809207 0.523 rs2783707 chr1:26504196 C/G cg24519413 chr1:26490540 NA 0.37 6.28 0.33 1.05e-9 Height; CRC cis rs736408 0.688 rs2239551 chr3:52818579 A/G cg10802521 chr3:52805072 NEK4 0.59 8.92 0.44 3.28e-17 Bipolar disorder; CRC trans rs9291683 0.588 rs12647117 chr4:10022059 T/C cg26043149 chr18:55253948 FECH 0.51 7.85 0.4 5.94e-14 Bone mineral density; CRC cis rs9462027 0.628 rs34141614 chr6:34777031 G/A cg07306190 chr6:34760872 UHRF1BP1 -0.34 -5.95 -0.31 6.95e-9 Systemic lupus erythematosus; CRC trans rs1945213 0.694 rs10895985 chr11:55831595 T/C cg15704280 chr7:45808275 SEPT13 0.55 6.16 0.32 2.15e-9 Acute lymphoblastic leukemia (childhood); CRC cis rs11645898 0.935 rs72787094 chr16:72192613 C/A cg14768367 chr16:72042858 DHODH -0.59 -6.55 -0.34 2.2e-10 Blood protein levels; CRC cis rs10838708 1.000 rs10838708 chr11:47441513 G/A cg05585544 chr11:47624801 NA -0.43 -7.36 -0.38 1.44e-12 Height; CRC trans rs2797160 1.000 rs9491471 chr6:125991715 C/T cg05039488 chr6:79577232 IRAK1BP1 -0.46 -6.97 -0.36 1.79e-11 Endometrial cancer; CRC cis rs35000415 0.938 rs12706861 chr7:128616582 C/T cg19972273 chr7:128594194 NA 0.68 6.31 0.33 8.75e-10 Systemic lupus erythematosus; CRC cis rs35883536 0.647 rs10875314 chr1:101043207 G/C cg06223162 chr1:101003688 GPR88 -0.36 -6.61 -0.34 1.56e-10 Monocyte count; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg19069963 chr22:29663643 EWSR1;RHBDD3 0.37 6.11 0.32 2.82e-9 Liver disease severity in Alagille syndrome; CRC cis rs11122272 0.735 rs2474623 chr1:231513993 T/C cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.54 -8.11 -0.41 1.04e-14 Hemoglobin concentration; CRC cis rs9611565 0.527 rs2234053 chr22:41777315 G/T cg03806693 chr22:41940476 POLR3H -1.08 -13.76 -0.6 2.34e-34 Vitiligo; CRC trans rs9815354 0.857 rs73073252 chr3:42016891 C/T cg04440885 chr16:51146856 NA 0.52 6.04 0.32 4.21e-9 Pulse pressure;Diastolic blood pressure; CRC cis rs4988958 0.584 rs7559845 chr2:103046214 T/G cg03938978 chr2:103052716 IL18RAP 0.59 10.09 0.49 4.82e-21 Asthma (childhood onset); CRC cis rs1552244 1.000 rs12152515 chr3:10143976 C/T cg08888203 chr3:10149979 C3orf24 0.66 9.67 0.47 1.21e-19 Alzheimer's disease; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg05596267 chr15:34331198 CHRM5;AVEN 0.38 6.0 0.31 5.31e-9 Intelligence (multi-trait analysis); CRC cis rs1223397 0.938 rs13205692 chr6:13291560 C/T cg06879394 chr6:13274151 PHACTR1 0.53 6.21 0.32 1.57e-9 Blood pressure; CRC cis rs6499255 0.951 rs8054096 chr16:69695886 G/A cg04110750 chr16:69646130 NFAT5 -0.55 -7.63 -0.39 2.53e-13 IgE levels; CRC cis rs4819052 0.808 rs11909411 chr21:46676556 A/C cg11663144 chr21:46675770 NA -0.83 -14.06 -0.61 1.78e-35 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs9908102 0.740 rs7211778 chr17:12901227 A/C cg26162695 chr17:12921313 ELAC2 0.46 6.43 0.33 4.39e-10 Schizophrenia; CRC cis rs6570726 0.818 rs9390338 chr6:145908265 A/G cg13319975 chr6:146136371 FBXO30 -0.44 -6.47 -0.34 3.6e-10 Lobe attachment (rater-scored or self-reported); CRC trans rs2727020 0.523 rs7948958 chr11:49506749 G/A cg03929089 chr4:120376271 NA 0.74 9.72 0.47 8.79e-20 Coronary artery disease; CRC cis rs6582630 0.502 rs11520234 chr12:38255005 G/A cg26384229 chr12:38710491 ALG10B 0.69 9.22 0.45 3.69e-18 Drug-induced liver injury (flucloxacillin); CRC cis rs4665809 0.590 rs2033317 chr2:26477650 G/A cg26119090 chr2:26468346 HADHA;HADHB 1.0 14.61 0.63 1.33e-37 Gut microbiome composition (summer); CRC cis rs4466137 0.953 rs1420654 chr5:82975793 G/A cg15083037 chr5:83017644 HAPLN1 -0.46 -5.97 -0.31 6.03e-9 Prostate cancer; CRC cis rs9322193 0.886 rs10872652 chr6:150096439 C/T cg05861140 chr6:150128134 PCMT1 -0.43 -7.05 -0.36 1.03e-11 Lung cancer; CRC cis rs4242434 0.927 rs3735894 chr8:22454826 A/G cg03733263 chr8:22462867 KIAA1967 1.01 19.62 0.73 2.77e-57 Exploratory eye movement dysfunction in schizophrenia (cognitive search score); CRC cis rs919433 0.926 rs12618567 chr2:198148191 A/T cg20885578 chr2:198174922 NA -0.43 -6.93 -0.36 2.16e-11 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC cis rs55883249 0.957 rs10495572 chr2:9734859 C/G cg23886495 chr2:9695866 ADAM17 -0.5 -5.74 -0.3 2.21e-8 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; CRC cis rs2303759 0.918 rs4802597 chr19:49872085 C/T cg22307029 chr19:49891270 CCDC155 0.6 8.55 0.43 4.62e-16 Multiple sclerosis; CRC cis rs270601 0.770 rs1007602 chr5:131602166 T/C cg02033258 chr5:131593261 PDLIM4 0.46 8.66 0.43 2.08e-16 Acylcarnitine levels; CRC trans rs7301826 0.627 rs7315707 chr12:131272819 A/G cg26618056 chr16:25043323 NA 0.48 6.38 0.33 5.99e-10 Plasma plasminogen activator levels; CRC cis rs12681288 0.676 rs2701923 chr8:994605 A/G cg15309053 chr8:964076 NA 0.41 7.33 0.37 1.8e-12 Schizophrenia; CRC cis rs2953174 0.507 rs4234123 chr2:241541640 C/T cg07929629 chr2:241523174 NA 0.66 9.43 0.46 7.8e-19 Bipolar disorder; CRC cis rs780096 0.526 rs1260342 chr2:27663416 G/T cg24768116 chr2:27665128 KRTCAP3 -0.36 -8.22 -0.41 4.71e-15 Total body bone mineral density; CRC cis rs8077889 0.871 rs16940243 chr17:41900003 C/G cg16892393 chr17:41919603 NA 0.46 7.12 0.37 6.77e-12 Triglycerides; CRC cis rs2739330 0.753 rs4822452 chr22:24254363 C/T cg10150615 chr22:24372951 LOC391322 -0.61 -9.56 -0.47 2.97e-19 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs2072510 0.569 rs2540488 chr12:96426745 G/A cg15438951 chr12:96389694 HAL -0.51 -6.23 -0.32 1.46e-9 Metabolite levels (small molecules and protein measures); CRC cis rs4930103 0.935 rs11042170 chr11:2021625 C/T cg23202291 chr11:1979235 NA 0.47 6.41 0.33 5.08e-10 DNA methylation (parent-of-origin);DNA methylation (variation); CRC cis rs9372498 0.505 rs9489462 chr6:118927855 C/T cg22561889 chr6:118971681 C6orf204 0.5 6.25 0.33 1.24e-9 Diastolic blood pressure; CRC cis rs2120019 0.938 rs13056 chr15:75312187 A/G cg17294928 chr15:75287854 SCAMP5 -0.76 -11.11 -0.52 1.4e-24 Blood trace element (Zn levels); CRC cis rs1129187 0.755 rs13215983 chr6:42924193 C/T cg00597713 chr6:42947103 PEX6 -0.4 -5.69 -0.3 2.88e-8 Alzheimer's disease in APOE e4+ carriers; CRC cis rs4713118 0.513 rs9368547 chr6:28028067 A/G cg12172441 chr6:28176163 NA 0.49 6.64 0.34 1.28e-10 Parkinson's disease; CRC cis rs7493 0.755 rs13223537 chr7:94966167 C/T cg19678392 chr7:94953810 PON1 0.51 6.48 0.34 3.3e-10 Yu-Zhi constitution type in type 2 diabetes; CRC trans rs10504229 0.861 rs59873610 chr8:58172290 T/A cg04077850 chr5:125800366 GRAMD3 0.37 6.24 0.33 1.37e-9 Developmental language disorder (linguistic errors); CRC cis rs1577917 0.958 rs13207173 chr6:86457522 T/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.52 -6.93 -0.36 2.22e-11 Response to antipsychotic treatment; CRC cis rs992157 0.835 rs7559416 chr2:219150211 A/G cg04880052 chr2:219191631 PNKD -0.42 -6.66 -0.34 1.14e-10 Colorectal cancer; CRC cis rs35110281 0.811 rs2838339 chr21:45075750 A/G cg01579765 chr21:45077557 HSF2BP 0.4 7.72 0.39 1.42e-13 Mean corpuscular volume; CRC cis rs6687430 0.526 rs12117392 chr1:10608583 T/C cg17425144 chr1:10567563 PEX14 0.49 9.9 0.48 2.21e-20 Hand grip strength; CRC cis rs514406 0.861 rs10888755 chr1:53240829 A/G cg27535305 chr1:53392650 SCP2 0.38 7.08 0.36 8.86e-12 Monocyte count; CRC cis rs12477438 0.798 rs6716913 chr2:99580641 T/C cg26064155 chr2:99771622 LIPT1;TSGA10 -0.75 -10.56 -0.5 1.23e-22 Chronic sinus infection; CRC trans rs1814175 0.791 rs9787917 chr11:49937281 C/T cg21153622 chr11:89784906 NA -0.37 -5.99 -0.31 5.61e-9 Height; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg15600987 chr1:151483609 CGN 0.46 6.38 0.33 6.02e-10 Anxiety disorder; CRC cis rs4478858 0.647 rs10798836 chr1:31709214 C/T cg00250761 chr1:31883323 NA -0.43 -8.25 -0.41 3.92e-15 Alcohol dependence; CRC cis rs3796619 0.924 rs11940546 chr4:1072485 C/T cg11579758 chr4:1086637 RNF212 0.41 6.68 0.35 1.01e-10 Recombination rate (males); CRC cis rs864537 0.618 rs1214595 chr1:167427557 G/A cg22356347 chr1:167427500 CD247 -0.38 -5.7 -0.3 2.7e-8 Celiac disease or Rheumatoid arthritis;Celiac disease; CRC cis rs597583 0.950 rs473343 chr11:117408156 G/C cg27161313 chr11:117392002 DSCAML1 -0.4 -5.9 -0.31 9.03e-9 Putamen volume; CRC cis rs1865760 0.566 rs2032443 chr6:26046802 A/G cg18357526 chr6:26021779 HIST1H4A 0.42 5.91 0.31 8.69e-9 Height; CRC cis rs8060686 0.920 rs73591961 chr16:67801309 G/A cg08314208 chr16:67682810 RLTPR -0.65 -7.04 -0.36 1.12e-11 HDL cholesterol;Metabolic syndrome; CRC cis rs394563 0.601 rs432582 chr6:149794143 C/T cg07828024 chr6:149772892 ZC3H12D -0.41 -6.77 -0.35 5.83e-11 Dupuytren's disease; CRC cis rs11153730 0.503 rs283057 chr6:118625734 T/C cg15382696 chr6:118971807 C6orf204 -0.36 -5.71 -0.3 2.58e-8 QT interval;Heart rate;QRS duration;QRS complex (Sokolow-Lyon); CRC cis rs67311347 0.955 rs4973999 chr3:40460383 G/A cg24209194 chr3:40518798 ZNF619 0.45 6.89 0.36 2.81e-11 Renal cell carcinoma; CRC cis rs1218582 0.741 rs10908444 chr1:154840287 G/A cg06221963 chr1:154839813 KCNN3 -0.78 -16.18 -0.67 1.03e-43 Prostate cancer; CRC cis rs7618501 0.602 rs34831713 chr3:50118748 T/C cg05623727 chr3:50126028 RBM5 -0.44 -7.51 -0.38 5.58e-13 Intelligence (multi-trait analysis); CRC cis rs4975709 0.589 rs4975746 chr5:1861069 G/A cg12288994 chr5:1860383 NA 0.39 6.87 0.35 3.15e-11 Cardiovascular disease risk factors; CRC cis rs4713118 0.513 rs149989 chr6:27998184 T/A cg20615401 chr6:28092323 ZSCAN16 0.46 6.21 0.32 1.62e-9 Parkinson's disease; CRC cis rs17023223 0.537 rs12081198 chr1:119686104 A/C cg05756136 chr1:119680316 WARS2 -0.53 -7.3 -0.37 2.17e-12 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for BMI in active individuals; CRC cis rs11764590 0.950 rs55683212 chr7:2078855 G/C cg02825527 chr7:2087843 MAD1L1 -0.46 -5.65 -0.3 3.39e-8 Neuroticism; CRC trans rs11098499 0.909 rs9759478 chr4:120367998 G/A cg25214090 chr10:38739885 LOC399744 0.67 10.48 0.5 2.25e-22 Corneal astigmatism; CRC cis rs6500602 0.674 rs7191664 chr16:4541924 T/C cg06139259 chr16:4526053 HMOX2;NMRAL1 0.52 6.8 0.35 4.95e-11 Schizophrenia; CRC cis rs9325144 0.555 rs2387855 chr12:38687964 T/G cg26384229 chr12:38710491 ALG10B 0.55 8.33 0.42 2.15e-15 Morning vs. evening chronotype; CRC cis rs4285028 0.699 rs1344279 chr3:121615679 G/A cg20356878 chr3:121714668 ILDR1 -0.46 -6.13 -0.32 2.47e-9 Multiple sclerosis; CRC cis rs72772090 0.539 rs11743410 chr5:96124453 A/G cg17330273 chr5:96107758 CAST;ERAP1 -0.63 -5.96 -0.31 6.43e-9 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs7647973 0.580 rs7652746 chr3:49262307 C/T cg20833759 chr3:49053208 WDR6;DALRD3 -0.37 -6.19 -0.32 1.83e-9 Menarche (age at onset); CRC cis rs1816752 0.719 rs11841989 chr13:24997698 C/A cg02811702 chr13:24901961 NA 0.42 5.86 0.31 1.1e-8 Obesity-related traits; CRC cis rs10789491 1.000 rs10749863 chr1:47174328 C/T cg15501359 chr1:47185051 KIAA0494 0.75 9.02 0.45 1.59e-17 Response to hepatitis C treatment; CRC cis rs4728302 0.869 rs10224683 chr7:133590937 A/G cg03336402 chr7:133662267 EXOC4 0.43 6.36 0.33 6.87e-10 Intelligence;Intelligence (multi-trait analysis); CRC cis rs2836950 0.805 rs2836961 chr21:40627020 A/C cg11644478 chr21:40555479 PSMG1 -0.41 -5.64 -0.3 3.73e-8 Menarche (age at onset); CRC trans rs12699921 0.632 rs2691597 chr7:17870340 C/T cg02066331 chr6:17282778 RBM24 -0.36 -6.19 -0.32 1.8e-9 Fibrinogen levels; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg20803232 chr8:42995089 HGSNAT 0.5 7.29 0.37 2.27e-12 Response to antipsychotic treatment; CRC cis rs10504229 1.000 rs115548028 chr8:58170672 T/C cg02725872 chr8:58115012 NA -0.38 -6.43 -0.33 4.44e-10 Developmental language disorder (linguistic errors); CRC cis rs6952808 0.792 rs12531315 chr7:1953650 C/G cg00106254 chr7:1943704 MAD1L1 -0.5 -7.42 -0.38 9.76e-13 Bipolar disorder and schizophrenia; CRC cis rs6840360 0.541 rs4696251 chr4:152266326 T/C cg09659197 chr4:152720779 NA 0.34 6.63 0.34 1.41e-10 Intelligence (multi-trait analysis); CRC cis rs6545883 0.826 rs777590 chr2:61417145 C/G cg15711740 chr2:61764176 XPO1 -0.42 -5.66 -0.3 3.25e-8 Tuberculosis; CRC cis rs10791323 0.582 rs2723613 chr11:133706696 G/A cg06766960 chr11:133703094 NA -0.37 -6.16 -0.32 2.1e-9 Childhood ear infection; CRC cis rs11148252 0.846 rs8001624 chr13:53002995 T/C cg00495681 chr13:53174319 NA 0.57 8.54 0.43 4.9e-16 Lewy body disease; CRC cis rs4638749 0.677 rs10189396 chr2:108829637 A/G cg25838818 chr2:108905173 SULT1C2 -0.34 -5.71 -0.3 2.52e-8 Blood pressure; CRC cis rs1552244 0.882 rs36006511 chr3:10054191 C/T cg18598329 chr3:10140678 FANCD2;C3orf24 -0.83 -10.72 -0.51 3.41e-23 Alzheimer's disease; CRC cis rs9896933 0.561 rs2264375 chr17:80692709 T/A cg20578329 chr17:80767326 TBCD -0.81 -9.79 -0.48 4.92e-20 Bone mineral accretion in asthma (oral corticosteroid dose interaction); CRC cis rs11148252 0.875 rs4884452 chr13:52949784 C/T cg00495681 chr13:53174319 NA -0.54 -8.22 -0.41 4.86e-15 Lewy body disease; CRC cis rs11677370 0.561 rs13003140 chr2:3816759 G/T cg17052675 chr2:3827356 NA -0.6 -9.03 -0.45 1.49e-17 Type 2 diabetes; CRC cis rs17376456 0.877 rs7701974 chr5:93311417 C/T cg21475434 chr5:93447410 FAM172A 0.77 7.8 0.4 8.13e-14 Diabetic retinopathy; CRC cis rs1448094 0.967 rs7978132 chr12:86323484 T/C cg18827107 chr12:86230957 RASSF9 -0.37 -6.1 -0.32 2.98e-9 Major depressive disorder; CRC cis rs270601 0.690 rs162904 chr5:131595784 C/T cg11843238 chr5:131593191 PDLIM4 -0.5 -8.71 -0.43 1.55e-16 Acylcarnitine levels; CRC cis rs9910055 0.747 rs2905981 chr17:42238625 C/T cg16434002 chr17:42200994 HDAC5 -0.45 -6.17 -0.32 2.02e-9 Total body bone mineral density; CRC cis rs2382817 0.580 rs6756265 chr2:219095554 G/A cg00012203 chr2:219082015 ARPC2 -0.54 -8.52 -0.43 5.77e-16 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; CRC trans rs3749237 0.964 rs2234385 chr3:49846041 G/A cg21659725 chr3:3221576 CRBN 0.57 8.22 0.41 4.88e-15 Resting heart rate; CRC trans rs931812 0.895 rs7831714 chr8:101913987 C/T cg20993868 chr7:22813445 NA 0.49 8.93 0.44 3.17e-17 Attention deficit hyperactivity disorder and conduct disorder; CRC cis rs9916302 0.904 rs8076494 chr17:37516722 A/G cg15445000 chr17:37608096 MED1 -0.42 -9.08 -0.45 1.04e-17 Glomerular filtration rate (creatinine); CRC cis rs6921919 0.697 rs758398 chr6:28320674 C/T cg15845792 chr6:28175446 NA 0.5 6.79 0.35 5.21e-11 Autism spectrum disorder or schizophrenia; CRC cis rs9733 0.818 rs4970924 chr1:150633079 A/G cg18016565 chr1:150552671 MCL1 -0.42 -6.22 -0.32 1.5e-9 Tonsillectomy; CRC cis rs798554 0.660 rs2644296 chr7:2859061 A/T cg17321639 chr7:2759063 NA -0.38 -5.8 -0.3 1.58e-8 Height; CRC cis rs873946 0.648 rs12766050 chr10:134549108 G/A cg06453172 chr10:134556979 INPP5A -0.7 -8.61 -0.43 3.04e-16 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg04966789 chr14:35591779 PPP2R3C;KIAA0391 0.49 6.16 0.32 2.12e-9 Thyroid stimulating hormone; CRC cis rs4148883 0.651 rs2851301 chr4:100010127 C/T cg12011299 chr4:100065546 ADH4 0.53 11.51 0.54 5.44e-26 Alcohol dependence; CRC cis rs798554 0.759 rs1636255 chr7:2892804 A/C cg04166393 chr7:2884313 GNA12 -0.54 -7.13 -0.37 6.25e-12 Height; CRC cis rs62064224 0.589 rs9910731 chr17:30784034 A/G cg09324608 chr17:30823087 MYO1D 0.36 6.19 0.32 1.79e-9 Schizophrenia; CRC cis rs3996993 0.597 rs62412901 chr6:52724949 G/A cg20803780 chr6:52668592 GSTA1 0.39 6.6 0.34 1.62e-10 Hemoglobin concentration; CRC cis rs2046867 0.818 rs62249863 chr3:72868666 G/C cg25664220 chr3:72788482 NA -0.46 -6.62 -0.34 1.44e-10 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; CRC cis rs3736485 0.934 rs1902593 chr15:51882080 C/T cg08986416 chr15:51914746 DMXL2 -0.46 -6.56 -0.34 2.11e-10 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs10883723 0.737 rs7074444 chr10:104249922 A/G cg04362960 chr10:104952993 NT5C2 -0.41 -5.7 -0.3 2.64e-8 Allergic disease (asthma, hay fever or eczema); CRC cis rs1150688 1 rs1150688 chr6:28162780 T/C cg10876282 chr6:28092338 ZSCAN16 0.4 5.76 0.3 1.93e-8 Autism spectrum disorder or schizophrenia; CRC cis rs7937682 1.000 rs9734135 chr11:111536190 G/A cg09085632 chr11:111637200 PPP2R1B -1.01 -20.7 -0.75 1.52e-61 Primary sclerosing cholangitis; CRC cis rs8060686 0.920 rs2292316 chr16:67861134 C/G cg26727032 chr16:67993705 SLC12A4 0.6 7.36 0.38 1.44e-12 HDL cholesterol;Metabolic syndrome; CRC cis rs763121 0.814 rs5757212 chr22:39053757 G/C cg06022373 chr22:39101656 GTPBP1 0.82 13.86 0.61 1e-34 Menopause (age at onset); CRC cis rs79976124 0.837 rs75346757 chr6:66648386 A/T cg07460842 chr6:66804631 NA 0.76 9.43 0.46 7.35e-19 Type 2 diabetes; CRC cis rs4713118 0.587 rs9393899 chr6:28133528 G/C cg02683197 chr6:28174875 NA 0.87 10.73 0.51 3.25e-23 Parkinson's disease; CRC cis rs9640161 0.830 rs36069544 chr7:150061538 G/A cg13722127 chr7:150037890 RARRES2 0.4 5.75 0.3 2.05e-8 Blood protein levels;Circulating chemerin levels; CRC cis rs1552244 1.000 rs9824585 chr3:10114802 T/C cg18598329 chr3:10140678 FANCD2;C3orf24 -0.88 -12.26 -0.56 1.03e-28 Alzheimer's disease; CRC trans rs45509595 0.659 rs390764 chr6:27782535 C/T cg06606381 chr12:133084897 FBRSL1 -0.78 -6.64 -0.34 1.26e-10 Breast cancer; CRC cis rs13118159 0.836 rs2276903 chr4:1343405 A/G cg16405210 chr4:1374714 KIAA1530 -0.45 -6.34 -0.33 7.62e-10 Longevity; CRC cis rs10504229 0.728 rs17804666 chr8:58154473 C/T cg02290350 chr8:58132656 NA -0.51 -6.57 -0.34 1.98e-10 Developmental language disorder (linguistic errors); CRC cis rs17711722 0.565 rs4717276 chr7:65294741 G/T cg05627663 chr7:65219948 SNORA22;CCT6P1 0.64 10.01 0.48 8.96e-21 Calcium levels; CRC cis rs2046867 0.908 rs62251648 chr3:72806083 A/G cg25664220 chr3:72788482 NA -0.46 -6.39 -0.33 5.8e-10 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; CRC cis rs947211 0.948 rs1775143 chr1:205755550 C/T cg11965913 chr1:205819406 PM20D1 0.4 5.69 0.3 2.77e-8 Parkinson's disease; CRC cis rs270601 0.739 rs3900945 chr5:131592870 T/C cg24060327 chr5:131705240 SLC22A5 -0.36 -5.62 -0.3 4.15e-8 Acylcarnitine levels; CRC cis rs2249694 0.960 rs4335490 chr10:135402350 T/C cg20169779 chr10:135381914 SYCE1 -0.67 -11.46 -0.53 8.33e-26 Obesity-related traits; CRC cis rs501916 0.575 rs56345741 chr15:48065010 A/C cg16110827 chr15:48056943 SEMA6D -0.44 -6.49 -0.34 3.08e-10 Inflammatory bowel disease;Ulcerative colitis; CRC cis rs2576037 0.583 rs2187091 chr18:44520048 T/C cg19077165 chr18:44547161 KATNAL2 -0.69 -11.46 -0.53 8.12e-26 Personality dimensions; CRC cis rs4713118 0.539 rs200951 chr6:27835930 A/G cg21251018 chr6:28226885 NKAPL 0.52 8.02 0.4 1.86e-14 Parkinson's disease; CRC trans rs8002861 0.846 rs12869355 chr13:44478193 A/C cg12856521 chr11:46389249 DGKZ 0.41 6.56 0.34 2.1e-10 Leprosy; CRC cis rs75920871 0.502 rs7124996 chr11:116928006 C/T cg20608306 chr11:116969690 SIK3 -0.34 -6.58 -0.34 1.86e-10 Subjective well-being; CRC cis rs911119 0.779 rs3761280 chr20:23620076 A/G cg16589663 chr20:23618590 CST3 0.62 8.01 0.4 2.01e-14 Chronic kidney disease; CRC cis rs3857067 0.836 rs12501138 chr4:95098444 T/A cg11021082 chr4:95130006 SMARCAD1 -0.49 -7.65 -0.39 2.21e-13 QT interval; CRC cis rs4803468 1.000 rs10417997 chr19:41902361 G/A cg09537434 chr19:41945824 ATP5SL -0.92 -18.26 -0.71 6.14e-52 Height; CRC cis rs736408 0.545 rs6445529 chr3:52662722 T/A cg05573699 chr3:52720067 GNL3;PBRM1 -0.47 -6.9 -0.36 2.7e-11 Bipolar disorder; CRC cis rs9303401 0.703 rs8077052 chr17:57208921 T/G cg10487724 chr17:56770010 TEX14;RAD51C 0.46 6.63 0.34 1.4e-10 Cognitive test performance; CRC cis rs1448094 0.511 rs17345975 chr12:86202318 T/A cg00310523 chr12:86230176 RASSF9 0.37 6.34 0.33 7.77e-10 Major depressive disorder; CRC cis rs870825 0.616 rs61539306 chr4:185650276 C/T cg04058563 chr4:185651563 MLF1IP 0.72 9.19 0.45 4.44e-18 Blood protein levels; CRC cis rs12188164 0.762 rs11745923 chr5:475408 T/G cg14137381 chr5:502291 SLC9A3 -0.33 -5.65 -0.3 3.43e-8 Cystic fibrosis severity; CRC cis rs10504229 0.683 rs57866073 chr8:58139138 A/G cg24829409 chr8:58192753 C8orf71 -0.57 -8.03 -0.4 1.76e-14 Developmental language disorder (linguistic errors); CRC cis rs1448094 0.533 rs10863078 chr12:86152672 C/T cg25456477 chr12:86230367 RASSF9 -0.39 -6.54 -0.34 2.36e-10 Major depressive disorder; CRC cis rs2354432 0.943 rs6660219 chr1:146691404 A/T cg25205988 chr1:146714368 CHD1L 1.13 12.71 0.57 2.16e-30 Mitochondrial DNA levels; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg06112779 chr12:54982626 PPP1R1A 0.39 6.62 0.34 1.44e-10 Liver disease severity in Alagille syndrome; CRC cis rs9372498 0.572 rs56082110 chr6:118909480 A/G cg15382696 chr6:118971807 C6orf204 0.59 7.46 0.38 7.96e-13 Diastolic blood pressure; CRC cis rs11123610 0.520 rs7576146 chr2:3718393 A/C cg10645314 chr2:3704589 ALLC -0.55 -6.45 -0.34 4.02e-10 Response to inhaled corticosteroid treatment in asthma (change in FEV1); CRC cis rs17152411 1.000 rs17152374 chr10:126592644 T/C cg07906193 chr10:126599966 NA 0.54 5.64 0.3 3.67e-8 Height; CRC cis rs644799 1.000 rs617999 chr11:95589935 A/G cg25478527 chr11:95522999 CEP57;FAM76B 0.54 8.01 0.4 2.04e-14 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs10274279 1.000 rs73163816 chr7:157388126 C/G cg26886268 chr7:157387156 PTPRN2 -0.48 -5.81 -0.31 1.45e-8 Myopia (pathological); CRC cis rs908922 0.676 rs7532535 chr1:152517597 T/A cg23254163 chr1:152506842 NA 0.44 8.62 0.43 2.8e-16 Hair morphology; CRC cis rs6912958 0.515 rs381782 chr6:88040649 C/T cg04972856 chr6:88032051 C6orf162;GJB7 0.35 6.5 0.34 2.92e-10 Monocyte percentage of white cells; CRC cis rs4713118 0.597 rs172166 chr6:28020820 C/G cg12273811 chr6:28175739 NA 0.61 8.39 0.42 1.45e-15 Parkinson's disease; CRC cis rs172166 0.516 rs2021826 chr6:28132756 G/A cg06470822 chr6:28175283 NA 0.66 10.08 0.49 5.48e-21 Cardiac Troponin-T levels; CRC cis rs9372498 0.706 rs9489396 chr6:118761703 A/C cg07617317 chr6:118971624 C6orf204 0.52 6.47 0.34 3.53e-10 Diastolic blood pressure; CRC cis rs7615952 0.932 rs13086087 chr3:125646281 A/C cg05084668 chr3:125655381 ALG1L -0.61 -9.17 -0.45 5.41e-18 Blood pressure (smoking interaction); CRC cis rs739401 0.595 rs6578304 chr11:2998279 A/G cg08508325 chr11:3079039 CARS 0.43 7.64 0.39 2.37e-13 Longevity; CRC cis rs7843479 0.506 rs7818430 chr8:21798429 C/T cg16476235 chr8:21771668 DOK2 0.37 6.18 0.32 1.89e-9 Mean corpuscular volume; CRC cis rs72781680 1.000 rs7578969 chr2:24168620 T/C cg08917208 chr2:24149416 ATAD2B 0.91 9.24 0.45 3.06e-18 Lymphocyte counts; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg14479329 chr6:167370587 RNASET2 0.52 8.36 0.42 1.8e-15 Liver disease severity in Alagille syndrome; CRC cis rs11190604 1.000 rs11190556 chr10:102209223 G/A cg07080220 chr10:102295463 HIF1AN 0.47 5.79 0.3 1.63e-8 Palmitoleic acid (16:1n-7) levels; CRC cis rs10504229 0.683 rs55714371 chr8:58131846 T/G cg05313129 chr8:58192883 C8orf71 -0.43 -6.11 -0.32 2.74e-9 Developmental language disorder (linguistic errors); CRC cis rs13108904 0.967 rs13149715 chr4:1278255 C/A cg05665937 chr4:1216051 CTBP1 0.4 5.8 0.3 1.54e-8 Obesity-related traits; CRC cis rs60012524 1 rs60012524 chr2:99559117 T/C cg26064155 chr2:99771622 LIPT1;TSGA10 -0.74 -8.99 -0.44 2.02e-17 Chronic sinus infection; CRC cis rs1801251 1.000 rs11555646 chr2:233599904 A/C cg25237894 chr2:233734115 C2orf82 0.53 8.62 0.43 2.89e-16 Coronary artery disease; CRC cis rs9549260 0.632 rs7323267 chr13:41204015 A/G cg21288729 chr13:41239152 FOXO1 0.48 5.91 0.31 8.66e-9 Red blood cell count; CRC trans rs10982213 0.830 rs2274163 chr9:117188714 C/T cg00282216 chr8:145823653 KIAA1688 -0.43 -6.67 -0.35 1.1e-10 Interleukin-6 levels; CRC cis rs9858542 0.953 rs7646366 chr3:49470668 G/A cg03060546 chr3:49711283 APEH -0.46 -6.49 -0.34 3.17e-10 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs4819052 0.851 rs9974891 chr21:46680767 T/A cg02159808 chr21:46707872 POFUT2;LOC642852 0.5 6.81 0.35 4.68e-11 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs270601 0.633 rs4535443 chr5:131572561 A/G cg02033258 chr5:131593261 PDLIM4 0.49 8.75 0.43 1.13e-16 Acylcarnitine levels; CRC cis rs863345 0.604 rs10797022 chr1:158494193 T/C cg12129480 chr1:158549410 OR10X1 -0.29 -5.93 -0.31 7.72e-9 Pneumococcal bacteremia; CRC cis rs951366 0.559 rs823101 chr1:205667006 T/C cg07167872 chr1:205819463 PM20D1 0.74 10.58 0.5 1.06e-22 Menarche (age at onset); CRC cis rs7086627 0.515 rs10887901 chr10:82210581 G/A cg00277334 chr10:82204260 NA -0.84 -16.97 -0.68 7.46e-47 Post bronchodilator FEV1; CRC cis rs939584 1.000 rs13386627 chr2:650560 G/C cg03610516 chr2:642275 NA -0.42 -5.89 -0.31 9.71e-9 Body mass index; CRC cis rs3785574 0.886 rs62077504 chr17:61837734 A/G cg23090583 chr17:61904693 PSMC5;FTSJ3 0.65 9.5 0.46 4.53e-19 Height; CRC cis rs9611565 0.512 rs4822052 chr22:42193741 G/A cg03806693 chr22:41940476 POLR3H -1.01 -12.66 -0.57 3.28e-30 Vitiligo; CRC cis rs6547741 0.844 rs9941696 chr2:27920064 C/T cg27432699 chr2:27873401 GPN1 -0.86 -17.02 -0.68 4.83e-47 Oral cavity cancer; CRC cis rs12477438 0.798 rs1993230 chr2:99686079 T/C cg14399236 chr2:99771627 LIPT1;TSGA10 -0.74 -10.35 -0.5 6.51e-22 Chronic sinus infection; CRC cis rs1552244 0.554 rs13081079 chr3:10056348 A/G cg13047869 chr3:10149882 C3orf24 0.38 5.81 0.31 1.48e-8 Alzheimer's disease; CRC cis rs6502050 0.835 rs8074267 chr17:80158325 A/G cg19223190 chr17:80058835 NA 0.41 6.7 0.35 8.79e-11 Life satisfaction; CRC cis rs4819052 0.851 rs914214 chr21:46697820 G/T cg19498844 chr21:46707878 POFUT2;LOC642852 0.79 11.53 0.54 4.72e-26 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs3126085 0.935 rs6587651 chr1:152193121 G/T cg09127314 chr1:152161683 NA 0.51 6.46 0.34 3.81e-10 Atopic dermatitis; CRC cis rs597539 0.652 rs501799 chr11:68631240 G/T cg06112835 chr11:68658793 MRPL21 0.39 6.46 0.34 3.7e-10 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs7772486 0.790 rs2253654 chr6:146199445 T/C cg13319975 chr6:146136371 FBXO30 -0.48 -7.27 -0.37 2.69e-12 Lobe attachment (rater-scored or self-reported); CRC cis rs9916302 0.904 rs8076546 chr17:37555403 G/A cg07936489 chr17:37558343 FBXL20 0.77 11.55 0.54 4.07e-26 Glomerular filtration rate (creatinine); CRC cis rs11098499 0.874 rs6822498 chr4:120120183 T/C cg24375607 chr4:120327624 NA 0.48 7.25 0.37 3.02e-12 Corneal astigmatism; CRC cis rs11190604 1.000 rs7905961 chr10:102297391 G/C cg07080220 chr10:102295463 HIF1AN 0.49 6.32 0.33 8.51e-10 Palmitoleic acid (16:1n-7) levels; CRC cis rs9488822 0.636 rs11153592 chr6:116330574 T/C cg26893134 chr6:116381904 FRK 0.26 7.6 0.39 3.02e-13 Cholesterol, total;LDL cholesterol; CRC trans rs4332037 0.624 rs11764124 chr7:1891723 C/G cg11693508 chr17:37793320 STARD3 0.64 8.4 0.42 1.37e-15 Bipolar disorder; CRC cis rs4862750 0.914 rs1991255 chr4:187875340 G/A cg27532560 chr4:187881888 NA -0.56 -10.16 -0.49 2.83e-21 Lobe attachment (rater-scored or self-reported); CRC cis rs7666738 0.830 rs10001701 chr4:98918871 G/C cg05340658 chr4:99064831 C4orf37 0.55 8.2 0.41 5.28e-15 Colonoscopy-negative controls vs population controls; CRC cis rs2075671 0.855 rs11974395 chr7:100282538 G/A cg00334542 chr7:100209784 MOSPD3 -0.52 -6.63 -0.34 1.38e-10 Other erythrocyte phenotypes; CRC cis rs116095464 0.558 rs6555056 chr5:226222 T/C cg22857025 chr5:266934 NA -1.21 -16.66 -0.68 1.3e-45 Breast cancer; CRC cis rs79349575 0.749 rs519537 chr17:46971140 G/A cg22482690 chr17:47019901 SNF8 0.48 7.96 0.4 2.83e-14 Type 2 diabetes; CRC cis rs9487051 0.872 rs9398197 chr6:109609988 C/A cg21918786 chr6:109611834 NA -0.45 -8.19 -0.41 5.98e-15 Reticulocyte fraction of red cells; CRC cis rs9926296 0.744 rs460984 chr16:89713174 C/T cg01097406 chr16:89675127 NA 0.53 9.68 0.47 1.17e-19 Vitiligo; CRC cis rs6693567 0.545 rs1694386 chr1:150377965 C/G cg15654264 chr1:150340011 RPRD2 0.42 6.2 0.32 1.68e-9 Migraine; CRC cis rs10911251 0.546 rs2027085 chr1:183108611 G/T ch.1.3577855R chr1:183094577 LAMC1 -0.8 -14.31 -0.62 1.91e-36 Colorectal cancer; CRC trans rs10982213 0.830 rs2274163 chr9:117188714 C/T cg08187779 chr8:102217898 ZNF706 0.41 6.8 0.35 4.99e-11 Interleukin-6 levels; CRC cis rs2153535 0.541 rs5026687 chr6:8473957 A/T cg07606381 chr6:8435919 SLC35B3 0.68 10.85 0.51 1.17e-23 Motion sickness; CRC cis rs1577917 0.796 rs12661231 chr6:86544471 T/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.44 -5.81 -0.31 1.46e-8 Response to antipsychotic treatment; CRC cis rs6844506 0.565 rs10008153 chr4:185227184 C/T cg06915193 chr4:185205329 NA -0.38 -5.93 -0.31 7.46e-9 Gestational age at birth in premature rupture of membrane-initiated deliveries (child effect); CRC cis rs1799949 1.000 rs8077486 chr17:41212805 C/T cg23758822 chr17:41437982 NA 0.84 15.36 0.65 1.54e-40 Menopause (age at onset); CRC cis rs3106136 0.903 rs35361491 chr4:95202492 G/A cg11021082 chr4:95130006 SMARCAD1 -0.47 -7.27 -0.37 2.66e-12 Capecitabine sensitivity; CRC cis rs6754311 0.773 rs1435576 chr2:136641882 A/T cg25344623 chr2:136566232 LCT -0.32 -5.87 -0.31 1.06e-8 Mosquito bite size; CRC trans rs9585327 0.584 rs4772260 chr13:100645723 A/G cg14010720 chr20:62168878 PTK6 0.29 6.38 0.33 5.99e-10 Myopia; CRC cis rs801193 1.000 rs2659912 chr7:66157999 G/C cg00343986 chr7:65444356 GUSB 0.49 7.22 0.37 3.53e-12 Aortic root size; CRC cis rs1799949 0.931 rs9912203 chr17:41445145 A/G cg19454999 chr17:41278357 BRCA1;NBR2 -0.41 -6.49 -0.34 3.21e-10 Menopause (age at onset); CRC trans rs7615952 0.546 rs4428131 chr3:125346479 C/T cg07211511 chr3:129823064 LOC729375 -0.63 -7.32 -0.37 1.96e-12 Blood pressure (smoking interaction); CRC cis rs250677 0.958 rs43147 chr5:148417103 C/G cg23229984 chr5:148520753 ABLIM3 -0.52 -7.19 -0.37 4.5e-12 Breast cancer; CRC cis rs2580764 0.598 rs7340476 chr2:55227346 G/C cg09592903 chr2:55203963 RTN4 -0.73 -11.89 -0.55 2.25e-27 Mean platelet volume; CRC cis rs10504229 0.683 rs56058640 chr8:58128862 C/T cg02725872 chr8:58115012 NA -0.64 -11.55 -0.54 3.85e-26 Developmental language disorder (linguistic errors); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg05521474 chr5:135082196 NA -0.41 -6.73 -0.35 7.34e-11 Liver disease severity in Alagille syndrome; CRC cis rs7917772 0.503 rs11191325 chr10:104302933 G/A cg22532475 chr10:104410764 TRIM8 -0.36 -6.62 -0.34 1.43e-10 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg06319359 chr1:22109595 USP48 0.45 6.33 0.33 8.16e-10 Anxiety disorder; CRC cis rs8060686 0.641 rs12445533 chr16:68082527 A/G cg08314208 chr16:67682810 RLTPR -0.57 -6.09 -0.32 3.17e-9 HDL cholesterol;Metabolic syndrome; CRC cis rs1008375 1.000 rs1558377 chr4:17650758 A/G cg02297831 chr4:17616191 MED28 0.5 6.71 0.35 8.74e-11 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs2976388 1.000 rs2294010 chr8:143762430 A/G cg24046110 chr8:143859143 LYNX1 -0.37 -6.43 -0.33 4.57e-10 Urinary tract infection frequency; CRC cis rs933688 1.000 rs6866191 chr5:90746852 G/A cg26981201 chr5:90679533 LOC100129716;ARRDC3 0.98 15.17 0.64 8.68e-40 Smoking behavior; CRC cis rs6543140 0.964 rs6543143 chr2:103085420 A/C cg09003973 chr2:102972529 NA 0.41 5.86 0.31 1.12e-8 Blood protein levels; CRC cis rs67981189 0.558 rs56043821 chr14:71570552 T/C cg15910301 chr14:71632612 NA 0.31 6.15 0.32 2.24e-9 Schizophrenia; CRC cis rs4727027 0.865 rs13236754 chr7:148845773 G/A cg23583168 chr7:148888333 NA -0.93 -16.33 -0.67 2.51e-44 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC cis rs1670533 0.932 rs4690214 chr4:1054636 T/C cg27284194 chr4:1044797 NA 0.5 6.2 0.32 1.66e-9 Recombination rate (females); CRC cis rs6951245 1.000 rs79327308 chr7:1108141 A/C cg24642844 chr7:1081250 C7orf50 -0.77 -9.29 -0.46 2.23e-18 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC trans rs55675132 0.548 rs12120506 chr1:115377777 C/T cg25493687 chr8:27288214 PTK2B 0.49 6.0 0.31 5.23e-9 Schizophrenia; CRC cis rs916888 0.773 rs199448 chr17:44809001 A/G cg17911788 chr17:44343683 NA -0.65 -7.55 -0.38 4.35e-13 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs6831352 0.734 rs1311620 chr4:100013091 C/T cg12011299 chr4:100065546 ADH4 0.45 8.69 0.43 1.77e-16 Alcohol dependence; CRC trans rs9329221 0.736 rs12548025 chr8:10260921 A/T cg06636001 chr8:8085503 FLJ10661 0.52 7.67 0.39 2e-13 Neuroticism; CRC cis rs2795502 0.564 rs11239844 chr10:43453365 G/A cg08461752 chr10:43522343 NA -0.63 -5.93 -0.31 7.78e-9 Blood protein levels; CRC cis rs17209837 0.607 rs1473154 chr7:87082042 A/G cg00919237 chr7:87102261 ABCB4 -0.54 -7.18 -0.37 4.66e-12 Gallbladder cancer; CRC cis rs7680126 0.596 rs10020887 chr4:10140751 C/G cg11266682 chr4:10021025 SLC2A9 -0.4 -5.9 -0.31 9e-9 Urate levels in lean individuals;Urate levels in overweight individuals;Urate levels in obese individuals; CRC cis rs7811142 1.000 rs1073 chr7:100031612 G/A cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.75 9.97 0.48 1.21e-20 Platelet count; CRC cis rs10504229 1.000 rs17216648 chr8:58169429 C/T cg05313129 chr8:58192883 C8orf71 -0.48 -7.23 -0.37 3.38e-12 Developmental language disorder (linguistic errors); CRC cis rs2836950 0.840 rs12482317 chr21:40588241 A/G cg11890956 chr21:40555474 PSMG1 -0.52 -6.78 -0.35 5.42e-11 Menarche (age at onset); CRC cis rs713477 1.000 rs8014526 chr14:55885054 C/G cg13175173 chr14:55914753 NA -0.47 -8.57 -0.43 4e-16 Pediatric bone mineral content (femoral neck); CRC cis rs9311474 0.607 rs34005367 chr3:52558904 A/T cg18404041 chr3:52824283 ITIH1 -0.35 -7.18 -0.37 4.7e-12 Electroencephalogram traits; CRC cis rs7647973 0.566 rs57630346 chr3:49086215 T/C cg20833759 chr3:49053208 WDR6;DALRD3 0.76 11.85 0.55 3.35e-27 Menarche (age at onset); CRC cis rs908922 0.743 rs10888499 chr1:152532742 C/A cg23254163 chr1:152506842 NA 0.43 7.36 0.38 1.48e-12 Hair morphology; CRC cis rs10743315 0.778 rs7397459 chr12:19377578 C/G cg02471346 chr12:19282374 PLEKHA5 0.61 7.9 0.4 4.32e-14 Gut microbiota (bacterial taxa); CRC trans rs1973993 0.745 rs56119386 chr1:96962215 C/T cg10631902 chr5:14652156 NA -0.4 -6.72 -0.35 7.89e-11 Weight; CRC cis rs10504229 0.600 rs6987243 chr8:58115406 T/C cg22535103 chr8:58192502 C8orf71 -0.7 -9.34 -0.46 1.47e-18 Developmental language disorder (linguistic errors); CRC cis rs644799 1.000 rs7749 chr11:95565789 G/A cg25622487 chr11:95524042 FAM76B;CEP57 0.76 11.95 0.55 1.39e-27 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs28386778 0.734 rs7210724 chr17:61799198 T/C cg06601766 chr17:61851465 DDX42;CCDC47 0.44 5.97 0.31 6.3e-9 Prudent dietary pattern; CRC cis rs6942756 1.000 rs11979476 chr7:128993756 G/T cg02491457 chr7:128862824 NA 0.74 9.91 0.48 2.05e-20 White matter hyperintensity burden; CRC cis rs7224737 1.000 rs9889640 chr17:40293497 C/T cg20291162 chr17:40259547 DHX58 -0.55 -8.01 -0.4 2.06e-14 Fibrinogen levels; CRC cis rs17345786 0.906 rs12638137 chr3:101150964 C/T cg11279151 chr3:101281821 RG9MTD1 -0.65 -7.76 -0.39 1.1e-13 Colonoscopy-negative controls vs population controls; CRC cis rs826838 0.967 rs12823908 chr12:38845686 T/C cg13010199 chr12:38710504 ALG10B 0.47 6.09 0.32 3.18e-9 Heart rate; CRC cis rs155076 0.711 rs4770131 chr13:21897468 A/G cg06138931 chr13:21896616 NA 0.54 6.87 0.35 3.16e-11 White matter hyperintensity burden; CRC trans rs79976124 0.837 rs11751145 chr6:66642039 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.75 9.58 0.47 2.49e-19 Type 2 diabetes; CRC cis rs62064224 0.554 rs9889352 chr17:30775761 T/C cg21839984 chr17:30846986 MYO1D -0.35 -5.89 -0.31 9.55e-9 Schizophrenia; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg26976744 chr8:120845108 TAF2 0.38 6.14 0.32 2.35e-9 Liver disease severity in Alagille syndrome; CRC cis rs10504229 0.683 rs73603874 chr8:58108340 G/A cg04204079 chr8:58130323 NA -0.46 -5.8 -0.3 1.58e-8 Developmental language disorder (linguistic errors); CRC cis rs2249625 0.564 rs2496489 chr6:72877338 G/A cg18830697 chr6:72922368 RIMS1 -0.4 -7.93 -0.4 3.37e-14 Acute urticaria and angioedema (non-steroidal anti-inflammatory drug-induced); CRC cis rs713477 0.654 rs6573030 chr14:55913720 T/G cg21836586 chr14:55907198 TBPL2 0.35 6.43 0.33 4.54e-10 Pediatric bone mineral content (femoral neck); CRC cis rs270601 0.739 rs1979981 chr5:131601720 G/A cg20512303 chr5:131592959 PDLIM4 0.4 7.55 0.38 4.36e-13 Acylcarnitine levels; CRC trans rs11088226 0.581 rs2833860 chr21:33882309 G/A cg09050820 chr6:167586206 TCP10L2 0.52 7.14 0.37 5.97e-12 Gastritis; CRC cis rs2439831 0.850 rs3862142 chr15:44064806 A/C cg02155558 chr15:43621948 ADAL;LCMT2 0.68 7.47 0.38 7.38e-13 Lung cancer in ever smokers; CRC cis rs9381040 0.610 rs9381028 chr6:41025081 C/A cg04346459 chr6:41068666 NFYA;LOC221442 -0.41 -6.14 -0.32 2.43e-9 Alzheimer's disease (late onset); CRC trans rs2814331 0.825 rs2814342 chr10:88003609 T/C cg23982858 chr12:95941869 USP44 -0.51 -6.05 -0.32 3.9e-9 Balding; CRC cis rs7917772 0.536 rs11191361 chr10:104411958 C/T cg22532475 chr10:104410764 TRIM8 -0.42 -7.03 -0.36 1.23e-11 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC cis rs2404602 0.716 rs7169394 chr15:76913274 G/A cg22467129 chr15:76604101 ETFA -0.38 -6.33 -0.33 8.22e-10 Blood metabolite levels; CRC cis rs7572644 0.679 rs4447576 chr2:28076248 T/C cg27432699 chr2:27873401 GPN1 0.45 6.1 0.32 3.03e-9 Response to carboplatin and paclitaxel in ovarian cancer (Caspase 3/7 EC50); CRC cis rs4666002 0.789 rs12998770 chr2:27913188 T/C cg27432699 chr2:27873401 GPN1 0.55 7.02 0.36 1.27e-11 Phospholipid levels (plasma); CRC cis rs11997175 0.574 rs4370495 chr8:33654819 G/A ch.8.33884649F chr8:33765107 NA 0.48 7.79 0.39 8.75e-14 Body mass index; CRC cis rs8103278 1.000 rs7258283 chr19:46335511 C/T cg16681516 chr19:46297285 DMWD 0.38 6.1 0.32 2.97e-9 Coronary artery disease; CRC cis rs1707322 0.963 rs11211202 chr1:46292382 C/T cg03146154 chr1:46216737 IPP 0.51 7.14 0.37 6.09e-12 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC trans rs7647973 0.593 rs7652179 chr3:49808618 T/A cg21659725 chr3:3221576 CRBN 0.61 6.32 0.33 8.72e-10 Menarche (age at onset); CRC cis rs7618915 0.547 rs62253703 chr3:52632357 T/C cg18404041 chr3:52824283 ITIH1 -0.42 -8.75 -0.43 1.14e-16 Bipolar disorder; CRC cis rs172166 0.516 rs2791333 chr6:28111114 A/G cg23161317 chr6:28129485 ZNF389 0.38 5.8 0.3 1.55e-8 Cardiac Troponin-T levels; CRC cis rs7811142 0.830 rs28495773 chr7:99943583 A/T cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.67 8.19 0.41 5.85e-15 Platelet count; CRC cis rs72627509 0.904 rs781663 chr4:57781754 A/G cg26694713 chr4:57773883 REST 0.45 5.61 0.3 4.3e-8 Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); CRC cis rs12143943 0.966 rs3789046 chr1:204586805 G/A cg17419461 chr1:204415978 PIK3C2B 0.41 6.22 0.32 1.47e-9 Cognitive performance; CRC cis rs9467160 1.000 rs9295624 chr6:24439600 A/G cg20631270 chr6:24437470 GPLD1 -0.51 -6.46 -0.34 3.81e-10 Liver enzyme levels; CRC cis rs6502050 0.835 rs8078950 chr17:80122327 T/G cg19223190 chr17:80058835 NA 0.39 6.23 0.32 1.43e-9 Life satisfaction; CRC cis rs4713118 0.784 rs9468219 chr6:27731755 C/A cg15786705 chr6:28176104 NA 0.54 7.17 0.37 4.95e-12 Parkinson's disease; CRC cis rs9916302 0.904 rs11869109 chr17:37518205 G/T cg00129232 chr17:37814104 STARD3 0.53 7.92 0.4 3.59e-14 Glomerular filtration rate (creatinine); CRC cis rs9326248 0.813 rs7115562 chr11:117020470 A/G cg11861562 chr11:117069780 TAGLN 0.34 6.33 0.33 8.16e-10 Blood protein levels; CRC cis rs6582630 0.519 rs12578283 chr12:38325349 A/T cg26384229 chr12:38710491 ALG10B 0.68 9.55 0.47 3.05e-19 Drug-induced liver injury (flucloxacillin); CRC cis rs3785574 0.962 rs62077483 chr17:61806380 C/T cg11494091 chr17:61959527 GH2 0.37 5.8 0.3 1.59e-8 Height; CRC cis rs709400 1.000 rs3783404 chr14:104118498 A/G cg12935359 chr14:103987150 CKB -0.37 -6.14 -0.32 2.44e-9 Body mass index; CRC cis rs2019137 0.905 rs2276561 chr2:113956371 G/C cg12889195 chr2:113992843 PAX8;LOC440839;LOC654433 -0.5 -7.22 -0.37 3.55e-12 Lymphocyte counts; CRC trans rs61931739 0.500 rs11053242 chr12:34511625 A/G cg13010199 chr12:38710504 ALG10B 0.45 6.51 0.34 2.88e-10 Morning vs. evening chronotype; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg05634287 chr5:148931071 CSNK1A1 0.4 6.13 0.32 2.58e-9 Intelligence (multi-trait analysis); CRC cis rs1552244 1.000 rs6442147 chr3:10078247 A/G cg00166722 chr3:10149974 C3orf24 0.63 8.73 0.43 1.3e-16 Alzheimer's disease; CRC cis rs2243480 1.000 rs4145008 chr7:65647511 T/G cg25985355 chr7:65971099 NA 0.52 6.01 0.31 4.92e-9 Diabetic kidney disease; CRC cis rs7666738 0.830 rs10012167 chr4:99048579 T/C cg05340658 chr4:99064831 C4orf37 0.6 9.35 0.46 1.4e-18 Colonoscopy-negative controls vs population controls; CRC cis rs17345786 0.861 rs79181492 chr3:101216021 G/A cg11279151 chr3:101281821 RG9MTD1 -0.64 -7.64 -0.39 2.35e-13 Colonoscopy-negative controls vs population controls; CRC cis rs73206853 0.543 rs7972256 chr12:110575444 G/A cg12870014 chr12:110450643 ANKRD13A 0.81 9.45 0.46 6.46e-19 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC cis rs4321325 0.733 rs13421996 chr2:127934812 G/T cg11380483 chr2:127933992 NA 0.63 7.74 0.39 1.28e-13 Protein C levels; CRC cis rs947211 1.000 rs947211 chr1:205752665 A/G cg14159672 chr1:205819179 PM20D1 0.41 5.62 0.3 4.13e-8 Parkinson's disease; CRC cis rs798554 0.797 rs798497 chr7:2795957 A/G cg04166393 chr7:2884313 GNA12 0.48 6.5 0.34 3.02e-10 Height; CRC cis rs2032447 0.531 rs428469 chr6:25898624 G/A cg12310025 chr6:25882481 NA -0.85 -12.07 -0.55 5e-28 Intelligence (multi-trait analysis); CRC trans rs492478 0.892 rs76693729 chr5:3933574 A/G cg09199442 chr11:28132951 METT5D1 -0.71 -6.34 -0.33 7.54e-10 Cognitive performance; CRC cis rs13088645 0.729 rs7620040 chr3:134163082 A/C cg06109529 chr3:134205091 CEP63;ANAPC13 -0.5 -7.48 -0.38 7e-13 Coronary artery disease; CRC cis rs9394159 0.583 rs4713650 chr6:33616828 C/T cg14003231 chr6:33640908 ITPR3 -0.56 -9.44 -0.46 7.1e-19 Graves' disease; CRC cis rs7677751 0.806 rs890203 chr4:55097405 A/C cg00691999 chr4:55094011 PDGFRA 0.42 5.98 0.31 5.66e-9 Corneal astigmatism; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg14756197 chr21:45196586 CSTB 0.44 6.16 0.32 2.15e-9 Anxiety disorder; CRC cis rs1348850 0.651 rs4893936 chr2:178240676 C/G cg22681709 chr2:178499509 PDE11A -0.32 -5.86 -0.31 1.1e-8 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs11229555 0.645 rs7931394 chr11:58212617 T/A cg15696309 chr11:58395628 NA -0.82 -10.45 -0.5 2.81e-22 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; CRC cis rs7552404 1.000 rs12091720 chr1:76186949 G/A cg22875332 chr1:76189707 ACADM 0.7 9.34 0.46 1.52e-18 Blood metabolite levels;Acylcarnitine levels; CRC cis rs7945705 0.935 rs2653567 chr11:8889630 T/C cg12365402 chr11:9010492 NRIP3 -0.49 -8.26 -0.41 3.66e-15 Hemoglobin concentration; CRC cis rs2976388 0.590 rs3758082 chr8:143824483 A/G cg20041105 chr8:143859282 LYNX1 -0.41 -6.78 -0.35 5.42e-11 Urinary tract infection frequency; CRC cis rs651907 0.514 rs12636046 chr3:101434448 T/G cg11279151 chr3:101281821 RG9MTD1 -0.56 -7.64 -0.39 2.42e-13 Colorectal cancer; CRC cis rs2075371 0.933 rs1833474 chr7:133958240 A/G cg20476274 chr7:133979776 SLC35B4 0.78 14.1 0.61 1.18e-35 Mean platelet volume; CRC trans rs12478296 1.000 rs73007138 chr2:243007041 C/T cg18288967 chr1:45987694 PRDX1 0.66 6.41 0.33 4.93e-10 Obesity-related traits; CRC cis rs2576037 0.583 rs501882 chr18:44411066 A/T cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.56 -8.37 -0.42 1.7e-15 Personality dimensions; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg10326891 chr4:88343821 NUDT9 0.39 6.06 0.32 3.76e-9 Liver disease severity in Alagille syndrome; CRC cis rs2836974 0.897 rs1984022 chr21:40596085 G/A cg11890956 chr21:40555474 PSMG1 1.09 18.64 0.72 1.93e-53 Cognitive function; CRC cis rs727505 0.607 rs66478705 chr7:124789211 C/G cg23710748 chr7:124431027 NA -0.64 -10.24 -0.49 1.56e-21 Lewy body disease; CRC cis rs2070488 0.896 rs11914389 chr3:38527215 T/C cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.86 16.07 0.66 2.72e-43 Electrocardiographic conduction measures; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg05926280 chr4:77997196 CCNI 0.41 6.0 0.31 5.11e-9 Response to antipsychotic treatment; CRC cis rs17443541 0.507 rs6742907 chr2:200455180 C/A cg03741458 chr2:200468445 NA -0.38 -5.95 -0.31 6.88e-9 Intelligence (multi-trait analysis); CRC cis rs921968 0.565 rs1529382 chr2:219626489 C/T cg02176678 chr2:219576539 TTLL4 -0.4 -6.4 -0.33 5.38e-10 Mean corpuscular hemoglobin concentration; CRC trans rs1814175 0.803 rs11040451 chr11:49650639 C/T cg03929089 chr4:120376271 NA -0.93 -17.05 -0.68 3.89e-47 Height; CRC trans rs916888 0.779 rs430685 chr17:44859148 T/C cg07870213 chr5:140052090 DND1 -0.85 -10.09 -0.49 4.88e-21 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs9910055 0.529 rs368328 chr17:42170289 G/A cg19774624 chr17:42201019 HDAC5 0.43 5.65 0.3 3.5e-8 Total body bone mineral density; CRC cis rs637571 0.584 rs7107912 chr11:65603252 G/A cg26695010 chr11:65641043 EFEMP2 0.56 8.88 0.44 4.37e-17 Eosinophil percentage of white cells; CRC cis rs1401999 0.606 rs939335 chr3:183745663 A/G cg05044414 chr3:183734942 ABCC5 0.42 7.49 0.38 6.38e-13 Anterior chamber depth; CRC cis rs2982552 0.903 rs2982555 chr6:152057656 A/C cg22157087 chr6:152012887 ESR1 0.39 5.94 0.31 7.16e-9 Bone properties (heel); CRC cis rs720844 1.000 rs13004738 chr2:149343644 C/T cg09247360 chr2:149335327 NA -0.62 -7.8 -0.39 8.45e-14 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs6502050 0.842 rs8080305 chr17:80074516 A/C cg25804541 chr17:80189381 SLC16A3 0.31 6.02 0.32 4.61e-9 Life satisfaction; CRC cis rs8064299 0.967 rs878905 chr17:72769411 G/A cg25054828 chr17:72772726 NAT9;TMEM104 0.63 10.11 0.49 4.12e-21 Monocyte count; CRC trans rs12408261 0.843 rs1342552 chr1:189311683 C/G cg20050113 chr2:103236861 SLC9A2 0.25 6.04 0.32 4.08e-9 Number of pregnancies; CRC cis rs6429082 0.509 rs2803845 chr1:235520228 C/G cg26050004 chr1:235667680 B3GALNT2 0.46 6.72 0.35 8.12e-11 Adiposity; CRC cis rs611744 0.647 rs585077 chr8:109245497 C/T cg18478394 chr8:109455254 TTC35 0.37 5.78 0.3 1.75e-8 Dupuytren's disease; CRC cis rs6951245 0.935 rs61753396 chr7:1105372 A/G cg21664854 chr7:1097933 C7orf50;GPR146 0.78 8.89 0.44 4.21e-17 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs7259376 0.905 rs8112246 chr19:22567447 C/T cg02657401 chr19:22469223 NA -0.33 -7.23 -0.37 3.4e-12 Menopause (age at onset); CRC cis rs11785400 1.000 rs7002932 chr8:143738816 C/A cg24634471 chr8:143751801 JRK 0.52 7.43 0.38 9.67e-13 Schizophrenia; CRC cis rs6714710 0.580 rs57804205 chr2:98454472 G/A cg26665480 chr2:98280029 ACTR1B 0.52 7.18 0.37 4.53e-12 Posterior cortical atrophy and Alzheimer's disease; CRC cis rs10197940 0.662 rs4335940 chr2:152275304 A/G cg06191203 chr2:152266755 RIF1 0.59 8.71 0.43 1.53e-16 Lung cancer; CRC cis rs763121 0.853 rs138705 chr22:39133803 C/T cg06022373 chr22:39101656 GTPBP1 0.79 11.86 0.55 2.92e-27 Menopause (age at onset); CRC cis rs6903823 0.527 rs4713158 chr6:28277771 C/A cg15845792 chr6:28175446 NA 0.47 6.5 0.34 3.06e-10 Pulmonary function; CRC trans rs2303319 0.504 rs60824222 chr2:162368719 A/C cg18122310 chr12:50236657 BCDIN3D -0.72 -6.07 -0.32 3.54e-9 Cognitive function; CRC cis rs1223397 0.938 rs3817738 chr6:13279388 G/T cg00460589 chr6:13274354 PHACTR1 0.51 5.97 0.31 6.03e-9 Blood pressure; CRC cis rs6502050 0.805 rs11077970 chr17:80085916 C/T cg13198984 chr17:80129470 CCDC57 -0.48 -8.5 -0.42 6.63e-16 Life satisfaction; CRC cis rs2070997 0.702 rs2229070 chr9:133760029 C/G cg01000188 chr9:133769184 QRFP 0.58 5.88 0.31 9.98e-9 Response to amphetamines; CRC cis rs6951245 1.000 rs11766526 chr7:1101433 G/A cg18402987 chr7:1209562 NA 0.67 7.17 0.37 5.02e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs5758511 0.680 rs739146 chr22:42660414 A/G cg00645731 chr22:42541494 CYP2D7P1 0.6 9.12 0.45 7.5e-18 Birth weight; CRC cis rs8062405 0.755 rs7193402 chr16:28586127 A/G cg16576597 chr16:28551801 NUPR1 0.56 8.38 0.42 1.6e-15 Cognitive ability (multi-trait analysis);Cognitive ability; CRC cis rs9372498 0.706 rs9489396 chr6:118761703 A/C cg01339444 chr6:118972232 C6orf204 0.52 5.9 0.31 8.98e-9 Diastolic blood pressure; CRC cis rs28386778 0.863 rs3760252 chr17:61852186 G/C cg06601766 chr17:61851465 DDX42;CCDC47 0.46 6.19 0.32 1.8e-9 Prudent dietary pattern; CRC cis rs11122272 0.766 rs2024879 chr1:231528638 A/G cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.55 -8.29 -0.42 2.99e-15 Hemoglobin concentration; CRC cis rs28386778 0.897 rs9912557 chr17:61784963 C/A cg23090583 chr17:61904693 PSMC5;FTSJ3 1.04 19.34 0.73 3.27e-56 Prudent dietary pattern; CRC trans rs13046373 0.905 rs4816372 chr21:32077414 A/T cg25840210 chr13:45152287 NA -0.4 -5.96 -0.31 6.45e-9 HDL cholesterol; CRC cis rs875971 1.000 rs778694 chr7:65871558 A/G cg12463550 chr7:65579703 CRCP 0.48 6.96 0.36 1.89e-11 Aortic root size; CRC trans rs12195424 0.730 rs9475698 chr6:56298924 A/G cg23260799 chr11:451101 PTDSS2 0.5 6.05 0.32 3.96e-9 Cerebrospinal fluid clusterin levels; CRC cis rs1035144 0.506 rs2371416 chr14:81275672 A/T cg06600135 chr14:81408086 NA -0.44 -6.36 -0.33 6.92e-10 Male sexual orientation; CRC cis rs8077889 0.871 rs17675370 chr17:41900030 T/C cg25876840 chr17:41920477 NA 0.61 8.53 0.43 5.25e-16 Triglycerides; CRC cis rs7811142 1.000 rs4463351 chr7:100078226 G/A cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.73 9.87 0.48 2.71e-20 Platelet count; CRC cis rs1707322 1.000 rs11211236 chr1:46443767 C/A cg03146154 chr1:46216737 IPP 0.51 7.06 0.36 1.01e-11 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs7973719 0.966 rs7310539 chr12:7329996 C/G cg07052231 chr12:7363540 PEX5 0.5 8.16 0.41 7.34e-15 IgG glycosylation; CRC cis rs947211 0.948 rs863725 chr1:205751196 C/T cg24503407 chr1:205819492 PM20D1 0.46 6.34 0.33 7.63e-10 Parkinson's disease; CRC cis rs9303280 0.806 rs10852935 chr17:38031674 C/T cg20243544 chr17:37824526 PNMT 0.37 5.69 0.3 2.79e-8 Self-reported allergy; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg10796467 chr19:11546103 CCDC151;PRKCSH 0.45 6.38 0.33 6.05e-10 Response to antipsychotic treatment; CRC cis rs2439831 0.850 rs12441984 chr15:44126285 C/G cg02155558 chr15:43621948 ADAL;LCMT2 0.71 7.53 0.38 4.91e-13 Lung cancer in ever smokers; CRC trans rs2303319 0.504 rs62189043 chr2:162608466 A/T cg25193742 chr10:104614220 C10orf32 -0.77 -6.51 -0.34 2.87e-10 Cognitive function; CRC trans rs7395662 0.963 rs8189397 chr11:48711870 A/T cg21153622 chr11:89784906 NA -0.48 -7.72 -0.39 1.45e-13 HDL cholesterol; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg24094675 chr7:1015382 COX19 0.45 6.85 0.35 3.64e-11 Response to antipsychotic treatment; CRC cis rs9291683 0.546 rs6829727 chr4:10051672 A/C cg00071950 chr4:10020882 SLC2A9 0.59 10.17 0.49 2.63e-21 Bone mineral density; CRC cis rs9910055 0.659 rs7216294 chr17:42251095 T/C cg19774624 chr17:42201019 HDAC5 -0.74 -12.06 -0.55 5.72e-28 Total body bone mineral density; CRC cis rs2976388 1.000 rs2920293 chr8:143765414 C/G cg04969067 chr8:143858791 LYNX1 -0.36 -6.07 -0.32 3.58e-9 Urinary tract infection frequency; CRC cis rs11792861 0.619 rs2289480 chr9:111705501 A/C cg14432460 chr9:111696404 IKBKAP;C9orf6 0.51 7.23 0.37 3.36e-12 Menarche (age at onset); CRC trans rs2243480 1.000 rs160646 chr7:65556280 C/T cg10756647 chr7:56101905 PSPH 0.69 7.54 0.38 4.72e-13 Diabetic kidney disease; CRC cis rs9392556 0.600 rs611500 chr6:4126763 C/G cg10424681 chr6:4079350 C6orf201;C6orf146 0.23 5.86 0.31 1.11e-8 Blood metabolite levels; CRC cis rs6952808 1.000 rs6977733 chr7:1886725 A/T cg20295408 chr7:1910781 MAD1L1 0.46 6.3 0.33 9.4e-10 Bipolar disorder and schizophrenia; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg02322140 chr16:9057781 USP7 0.45 6.08 0.32 3.34e-9 Anxiety disorder; CRC cis rs4363385 0.776 rs1890284 chr1:152942190 G/A cg25856811 chr1:152973957 SPRR3 -0.21 -5.82 -0.31 1.4e-8 Inflammatory skin disease; CRC cis rs6964587 0.900 rs11984136 chr7:91766953 T/C cg17063962 chr7:91808500 NA 0.85 15.02 0.64 3.54e-39 Breast cancer; CRC cis rs3733346 0.553 rs6813110 chr4:942660 C/T cg22718636 chr4:961658 DGKQ 0.28 5.99 0.31 5.52e-9 Sjögren's syndrome; CRC cis rs911119 0.954 rs2254635 chr20:23622758 G/T cg16589663 chr20:23618590 CST3 0.59 8.57 0.43 4.05e-16 Chronic kidney disease; CRC cis rs939584 1.000 rs7601028 chr2:642499 C/G cg03610516 chr2:642275 NA 0.42 5.88 0.31 9.94e-9 Body mass index; CRC cis rs11864453 0.713 rs7190995 chr16:72124157 A/G cg23815491 chr16:72088622 HP 0.5 7.6 0.39 3.09e-13 Fibrinogen levels; CRC cis rs3749237 0.555 rs7637665 chr3:49552295 T/C cg02487422 chr3:49467188 NICN1 0.43 6.91 0.36 2.57e-11 Resting heart rate; CRC cis rs10504229 0.817 rs10504230 chr8:58197150 A/G cg05313129 chr8:58192883 C8orf71 0.45 5.88 0.31 1.02e-8 Developmental language disorder (linguistic errors); CRC cis rs9611565 0.694 rs11090056 chr22:42095904 A/C cg03806693 chr22:41940476 POLR3H 0.68 9.48 0.46 5.11e-19 Vitiligo; CRC cis rs1355223 0.867 rs7925421 chr11:34681677 G/A cg11058730 chr11:34937778 PDHX;APIP -0.43 -5.92 -0.31 8.2e-9 Systemic lupus erythematosus and Systemic sclerosis; CRC cis rs908922 0.676 rs7530609 chr1:152526812 C/A cg09873164 chr1:152488093 CRCT1 0.36 6.13 0.32 2.48e-9 Hair morphology; CRC trans rs10504229 1.000 rs67388517 chr8:58176617 C/A cg04077850 chr5:125800366 GRAMD3 0.37 6.27 0.33 1.15e-9 Developmental language disorder (linguistic errors); CRC cis rs7811142 1.000 rs7783550 chr7:99987805 A/G cg01860168 chr7:100026446 MEPCE;ZCWPW1 -0.58 -7.61 -0.39 2.94e-13 Platelet count; CRC cis rs3806843 0.966 rs3756338 chr5:140180561 A/G cg19875535 chr5:140030758 IK 0.63 10.23 0.49 1.61e-21 Depressive symptoms (multi-trait analysis); CRC trans rs7613875 0.521 rs4688754 chr3:50074641 G/T cg21659725 chr3:3221576 CRBN -0.44 -6.5 -0.34 2.92e-10 Body mass index; CRC cis rs6502050 0.799 rs4789680 chr17:80100547 C/A cg09264619 chr17:80180166 NA -0.34 -5.81 -0.3 1.5e-8 Life satisfaction; CRC cis rs938554 0.577 rs7683856 chr4:10000947 A/G cg11266682 chr4:10021025 SLC2A9 0.39 6.19 0.32 1.76e-9 Blood metabolite levels; CRC cis rs7591163 1.000 rs4973380 chr2:228725402 T/A cg20647610 chr2:228736258 WDR69 -0.48 -6.52 -0.34 2.58e-10 Blood pressure; CRC trans rs2727020 0.754 rs1851990 chr11:49413336 C/T cg15704280 chr7:45808275 SEPT13 -0.81 -11.5 -0.54 6.09e-26 Coronary artery disease; CRC cis rs7809950 0.723 rs62483634 chr7:106878516 G/A cg23024343 chr7:107201750 COG5 -0.62 -8.49 -0.42 7.24e-16 Coronary artery disease; CRC cis rs7677751 0.708 rs2052699 chr4:55063994 C/T cg17187183 chr4:55093834 PDGFRA 0.48 6.79 0.35 5.31e-11 Corneal astigmatism; CRC cis rs4243830 1.000 rs12046884 chr1:6594561 G/A cg05709478 chr1:6581295 PLEKHG5 0.64 6.3 0.33 9.37e-10 Body mass index; CRC cis rs9457247 0.935 rs2757050 chr6:167377165 G/T cg23791538 chr6:167370224 RNASET2 0.39 6.09 0.32 3.22e-9 Crohn's disease; CRC cis rs1046896 0.503 rs12947062 chr17:80686370 A/G cg19500275 chr17:80737654 TBCD -0.39 -5.94 -0.31 7.44e-9 Glycated hemoglobin levels; CRC cis rs4713118 0.868 rs9468220 chr6:27732976 A/G cg12172441 chr6:28176163 NA -0.6 -6.65 -0.34 1.22e-10 Parkinson's disease; CRC cis rs1799949 0.931 rs34410138 chr17:41279770 A/G cg23758822 chr17:41437982 NA 0.77 12.93 0.58 3.28e-31 Menopause (age at onset); CRC cis rs4819052 0.851 rs7279182 chr21:46656112 G/A cg19498844 chr21:46707878 POFUT2;LOC642852 0.71 9.6 0.47 2.12e-19 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs16975963 0.843 rs11083442 chr19:38427528 C/A cg15135657 chr19:38346511 NA -0.43 -5.75 -0.3 2.01e-8 Longevity; CRC cis rs10949834 0.504 rs13238778 chr7:73567709 G/A cg07137043 chr7:73588983 EIF4H -0.64 -6.88 -0.35 2.95e-11 Verbal memory performance (residualized delayed recall change); CRC cis rs11098499 0.954 rs3733524 chr4:120423729 T/C cg24375607 chr4:120327624 NA 0.53 8.0 0.4 2.08e-14 Corneal astigmatism; CRC cis rs68170813 0.559 rs76307631 chr7:107058018 A/G cg02696742 chr7:106810147 HBP1 -0.58 -5.98 -0.31 5.66e-9 Coronary artery disease; CRC cis rs9487051 0.768 rs437779 chr6:109527691 T/G cg01475377 chr6:109611718 NA -0.34 -5.91 -0.31 8.78e-9 Reticulocyte fraction of red cells; CRC cis rs1059312 0.808 rs4760537 chr12:129301299 C/A cg09035930 chr12:129282057 SLC15A4 0.5 8.43 0.42 1.12e-15 Systemic lupus erythematosus; CRC cis rs1552244 0.832 rs73024591 chr3:10203194 A/T cg02579736 chr3:10068473 FANCD2;CIDECP 1.0 11.17 0.52 8.95e-25 Alzheimer's disease; CRC cis rs6570726 1.000 rs373778 chr6:145873252 C/T cg05347473 chr6:146136440 FBXO30 0.4 6.23 0.32 1.45e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs7072216 0.763 rs7091709 chr10:100167605 G/A cg26618903 chr10:100175079 PYROXD2 -0.51 -8.31 -0.42 2.54e-15 Metabolite levels; CRC cis rs10504229 1.000 rs59549824 chr8:58186205 A/C cg22535103 chr8:58192502 C8orf71 -0.82 -12.25 -0.56 1.1e-28 Developmental language disorder (linguistic errors); CRC cis rs9943753 0.525 rs983307 chr12:109815103 T/G cg19025524 chr12:109796872 NA -0.53 -8.01 -0.4 1.99e-14 HDL cholesterol; CRC cis rs1153858 1.000 rs12593370 chr15:45617417 C/T cg21132104 chr15:45694354 SPATA5L1 0.6 8.45 0.42 9.39e-16 Homoarginine levels; CRC cis rs896854 0.846 rs7845219 chr8:95937502 T/C cg09323728 chr8:95962352 TP53INP1 -0.41 -6.41 -0.33 5e-10 Type 2 diabetes; CRC cis rs4965869 0.866 rs2412012 chr15:101974653 C/T cg12371147 chr15:101978424 PCSK6 -0.41 -5.78 -0.3 1.75e-8 Platelet-derived growth factor BB levels; CRC cis rs1691799 0.899 rs1168328 chr12:66729250 T/C cg16791601 chr12:66731901 HELB -0.74 -13.04 -0.58 1.25e-31 White blood cell count (basophil); CRC cis rs868943 0.714 rs4415182 chr6:116382811 G/A cg05304507 chr6:116381966 FRK 0.29 6.45 0.34 3.96e-10 Total cholesterol levels; CRC cis rs12760731 0.720 rs35215865 chr1:178313756 G/A cg00404053 chr1:178313656 RASAL2 1.2 10.39 0.5 4.61e-22 Obesity-related traits; CRC cis rs10426930 0.607 rs2613762 chr19:5064948 T/G cg18473234 chr19:5097819 KDM4B -0.54 -6.73 -0.35 7.68e-11 Monocyte percentage of white cells; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg21545977 chr1:11741439 MAD2L2 0.48 6.53 0.34 2.46e-10 Anxiety disorder; CRC cis rs12042938 0.579 rs980394 chr1:231779507 A/G cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.47 -6.5 -0.34 3.05e-10 Neuranatomic and neurocognitive phenotypes; CRC cis rs2239547 0.563 rs6445547 chr3:52908577 T/C cg10802521 chr3:52805072 NEK4 -0.47 -6.45 -0.34 4.01e-10 Schizophrenia; CRC cis rs990171 0.506 rs9284725 chr2:102744854 C/A cg22835712 chr2:102737379 NA 0.46 6.29 0.33 9.9e-10 Lymphocyte counts; CRC cis rs13118159 0.550 rs4974611 chr4:1358449 T/C cg02475777 chr4:1388615 CRIPAK 0.51 6.49 0.34 3.07e-10 Longevity; CRC cis rs7772486 0.743 rs62433835 chr6:146032688 C/G cg13319975 chr6:146136371 FBXO30 0.4 5.89 0.31 9.62e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs7312933 0.510 rs1907705 chr12:42451122 T/A cg17420585 chr12:42539391 GXYLT1 -0.66 -11.4 -0.53 1.4e-25 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CRC cis rs4728142 1.000 rs4728142 chr7:128573967 C/T cg06630958 chr7:128577819 IRF5 -0.46 -7.88 -0.4 4.79e-14 Inflammatory bowel disease;Systemic lupus erythematosus;Ulcerative colitis; CRC cis rs1577917 0.958 rs114467802 chr6:86572350 T/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.51 -6.81 -0.35 4.6e-11 Response to antipsychotic treatment; CRC cis rs55702914 0.712 rs12619296 chr2:198148767 A/G cg20885578 chr2:198174922 NA -0.34 -5.99 -0.31 5.45e-9 Major depression and alcohol dependence; CRC cis rs853679 0.760 rs9393909 chr6:28207200 A/G cg15845792 chr6:28175446 NA -0.57 -5.61 -0.3 4.21e-8 Depression; CRC cis rs6500602 0.647 rs4786501 chr16:4536165 G/T cg14951292 chr16:4525986 HMOX2;NMRAL1 -0.54 -7.99 -0.4 2.33e-14 Schizophrenia; CRC cis rs7605827 0.930 rs10168299 chr2:15615063 A/G cg19274914 chr2:15703543 NA 0.39 5.9 0.31 8.83e-9 Educational attainment (years of education); CRC cis rs6921919 0.583 rs3734563 chr6:28349725 A/G cg21251018 chr6:28226885 NKAPL 0.39 5.95 0.31 6.81e-9 Autism spectrum disorder or schizophrenia; CRC cis rs1580019 0.587 rs9638880 chr7:32552401 A/G cg07520158 chr7:32535189 LSM5;AVL9 0.53 7.86 0.4 5.59e-14 Cognitive ability; CRC cis rs514406 0.505 rs427319 chr1:53178807 T/G cg24675658 chr1:53192096 ZYG11B -0.66 -9.92 -0.48 1.78e-20 Monocyte count; CRC cis rs270601 0.909 rs2569265 chr5:131704519 T/C cg27615366 chr5:131592974 PDLIM4 -0.32 -5.63 -0.3 3.93e-8 Acylcarnitine levels; CRC cis rs66573146 0.572 rs67252699 chr4:6946411 A/G cg00086871 chr4:6988644 TBC1D14 0.84 8.08 0.41 1.22e-14 Granulocyte percentage of myeloid white cells; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg02008025 chr2:102314465 MAP4K4 0.45 6.57 0.34 2.03e-10 Intelligence (multi-trait analysis); CRC cis rs8062405 1.000 rs8055982 chr16:28881202 A/C cg16576597 chr16:28551801 NUPR1 0.48 6.8 0.35 4.9e-11 Cognitive ability (multi-trait analysis);Cognitive ability; CRC cis rs7107174 1.000 rs2450122 chr11:77930345 T/C cg02023728 chr11:77925099 USP35 0.49 7.35 0.38 1.54e-12 Testicular germ cell tumor; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg21739009 chr19:1591627 MBD3 0.42 5.97 0.31 6.23e-9 Response to antipsychotic treatment; CRC cis rs968567 1.000 rs968567 chr11:61595564 C/T cg14911132 chr11:61596755 FADS2 -0.52 -5.72 -0.3 2.43e-8 Blood metabolite levels;Rheumatoid arthritis;Vitiligo;Glycerophospholipid levels; CRC cis rs938554 0.784 rs11722229 chr4:9980697 C/A cg11266682 chr4:10021025 SLC2A9 0.35 5.62 0.3 4.06e-8 Blood metabolite levels; CRC trans rs7937682 0.889 rs2850247 chr11:111637202 C/A cg18187862 chr3:45730750 SACM1L -0.54 -8.28 -0.42 3.05e-15 Primary sclerosing cholangitis; CRC cis rs637571 0.510 rs10750772 chr11:65577427 C/T cg04055107 chr11:65626734 MUS81;CFL1 -0.42 -5.94 -0.31 7.11e-9 Eosinophil percentage of white cells; CRC cis rs597539 0.652 rs592697 chr11:68650064 G/A cg21963583 chr11:68658836 MRPL21 0.63 11.52 0.54 5.02e-26 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs12745968 0.590 rs1337107 chr1:93218776 A/G cg17283838 chr1:93427260 FAM69A -0.44 -6.05 -0.32 3.98e-9 Bipolar disorder and schizophrenia; CRC cis rs875971 0.862 rs1983372 chr7:65611351 C/T cg11764359 chr7:65958608 NA -0.61 -9.53 -0.47 3.59e-19 Aortic root size; CRC cis rs832540 0.669 rs832539 chr5:56199386 A/C cg18230493 chr5:56204884 C5orf35 -0.51 -7.41 -0.38 1.08e-12 Coronary artery disease; CRC cis rs208520 0.802 rs851600 chr6:66893754 T/C cg07460842 chr6:66804631 NA -0.93 -12.48 -0.57 1.55e-29 Exhaled nitric oxide output; CRC cis rs12142240 0.698 rs72677589 chr1:46817770 T/C cg14993813 chr1:46806288 NSUN4 -0.49 -6.23 -0.32 1.4e-9 Menopause (age at onset); CRC cis rs2404602 0.622 rs11632670 chr15:76974055 A/G cg03037974 chr15:76606532 NA -0.53 -8.33 -0.42 2.18e-15 Blood metabolite levels; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg23975375 chr4:103997221 NHEDC2 0.37 6.05 0.32 3.84e-9 Liver disease severity in Alagille syndrome; CRC cis rs79349575 0.783 rs17635252 chr17:47006950 T/C cg22482690 chr17:47019901 SNF8 0.47 7.94 0.4 3.2e-14 Type 2 diabetes; CRC cis rs4474465 1.000 rs7124092 chr11:78155086 T/C cg27205649 chr11:78285834 NARS2 -0.45 -5.75 -0.3 2.01e-8 Alzheimer's disease (survival time); CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg26755928 chr19:10363173 MRPL4 0.51 6.6 0.34 1.67e-10 Thyroid stimulating hormone; CRC cis rs889312 0.500 rs3099460 chr5:56133748 G/C cg18230493 chr5:56204884 C5orf35 -0.4 -5.98 -0.31 5.9e-9 Breast cancer;Breast cancer (early onset); CRC trans rs561341 1.000 rs537166 chr17:30326827 C/T cg20587970 chr11:113659929 NA -1.16 -16.97 -0.68 7.37e-47 Hip circumference adjusted for BMI; CRC cis rs8072100 0.701 rs2013383 chr17:45791123 T/G cg08550205 chr17:45786854 TBKBP1 -0.35 -5.75 -0.3 2.08e-8 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs1957429 0.901 rs8008745 chr14:65351593 C/G cg23373153 chr14:65346875 NA 0.81 8.53 0.43 5.51e-16 Pediatric areal bone mineral density (radius); CRC cis rs7122539 0.646 rs569818 chr11:66570749 G/A cg24851651 chr11:66362959 CCS 0.52 9.95 0.48 1.47e-20 HIV-1 susceptibility; CRC cis rs4665809 0.590 rs13387855 chr2:26420708 T/G cg04944784 chr2:26401820 FAM59B -0.82 -10.57 -0.5 1.14e-22 Gut microbiome composition (summer); CRC cis rs12477438 0.520 rs11689265 chr2:99799267 A/G cg14399236 chr2:99771627 LIPT1;TSGA10 0.83 14.6 0.63 1.45e-37 Chronic sinus infection; CRC cis rs28386778 0.799 rs2955234 chr17:61983601 A/C cg06873352 chr17:61820015 STRADA -0.73 -13.55 -0.6 1.48e-33 Prudent dietary pattern; CRC cis rs2976388 0.590 rs3736011 chr8:143817789 G/A cg24046110 chr8:143859143 LYNX1 -0.44 -7.07 -0.36 9.18e-12 Urinary tract infection frequency; CRC cis rs1862618 1.000 rs1862618 chr5:56096315 C/G cg12311346 chr5:56204834 C5orf35 -0.71 -9.53 -0.47 3.51e-19 Initial pursuit acceleration; CRC cis rs10193935 0.901 rs10171643 chr2:42532912 C/T cg27598129 chr2:42591480 NA -0.63 -7.32 -0.37 1.9e-12 Colonoscopy-negative controls vs population controls; CRC cis rs6570726 0.935 rs414646 chr6:145831685 T/C cg05347473 chr6:146136440 FBXO30 0.37 6.0 0.31 5.27e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs9359856 0.510 rs74437492 chr6:90338728 A/G cg13799429 chr6:90582589 CASP8AP2 -0.78 -10.02 -0.48 8.18e-21 Bipolar disorder; CRC cis rs910316 0.967 rs175479 chr14:75561871 A/C cg11812906 chr14:75593930 NEK9 -0.59 -9.36 -0.46 1.29e-18 Height; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg11152033 chr20:61542496 DIDO1 -0.38 -6.14 -0.32 2.41e-9 Liver disease severity in Alagille syndrome; CRC cis rs11098499 0.865 rs9994730 chr4:120381564 A/C cg24375607 chr4:120327624 NA 0.49 7.61 0.39 3.01e-13 Corneal astigmatism; CRC cis rs6912958 0.712 rs2787927 chr6:88412786 A/G cg08069147 chr6:88032118 GJB7;C6orf162 -0.52 -7.38 -0.38 1.31e-12 Monocyte percentage of white cells; CRC cis rs6952808 0.689 rs11771625 chr7:2050401 C/T cg00106254 chr7:1943704 MAD1L1 -0.53 -7.79 -0.39 8.93e-14 Bipolar disorder and schizophrenia; CRC cis rs908922 0.651 rs10888493 chr1:152503913 G/A cg09873164 chr1:152488093 CRCT1 0.38 6.28 0.33 1.04e-9 Hair morphology; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg04152460 chr6:28109974 ZNF192 0.47 6.57 0.34 1.93e-10 Response to antipsychotic treatment; CRC cis rs7208859 0.524 rs8065744 chr17:29099449 C/T cg13385521 chr17:29058706 SUZ12P 0.73 8.4 0.42 1.39e-15 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs7591163 1.000 rs6738964 chr2:228739135 G/T cg22079747 chr2:228736145 WDR69 -0.45 -6.23 -0.32 1.43e-9 Blood pressure; CRC cis rs7584330 0.554 rs6706729 chr2:238398580 T/C cg14458575 chr2:238380390 NA 0.83 10.4 0.5 4.44e-22 Prostate cancer; CRC cis rs11997175 0.624 rs4621768 chr8:33677452 T/C ch.8.33884649F chr8:33765107 NA 0.44 6.26 0.33 1.23e-9 Body mass index; CRC cis rs2749592 0.550 rs10764135 chr10:37866845 C/T cg25517755 chr10:38738941 LOC399744 0.42 5.98 0.31 5.86e-9 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs9443645 0.869 rs9343848 chr6:79621101 C/T cg09184832 chr6:79620586 NA -0.51 -9.58 -0.47 2.54e-19 Intelligence (multi-trait analysis); CRC cis rs853679 0.882 rs2743555 chr6:28241081 G/A cg06470822 chr6:28175283 NA 0.67 6.62 0.34 1.48e-10 Depression; CRC cis rs4481887 0.861 rs6681336 chr1:248482756 C/T cg00666640 chr1:248458726 OR2T12 0.46 7.97 0.4 2.59e-14 Common traits (Other); CRC cis rs75804782 0.522 rs11889150 chr2:239324542 A/G cg18131467 chr2:239335373 ASB1 -0.71 -8.88 -0.44 4.57e-17 Morning vs. evening chronotype;Chronotype; CRC cis rs9486719 1.000 rs12212614 chr6:97036466 T/G cg06623918 chr6:96969491 KIAA0776 -0.81 -9.44 -0.46 7.3e-19 Migraine;Coronary artery disease; CRC cis rs4727027 0.933 rs6955564 chr7:148866173 A/G cg23583168 chr7:148888333 NA -0.91 -16.07 -0.66 2.64e-43 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC cis rs6860806 0.661 rs3763112 chr5:131586480 A/G cg20512303 chr5:131592959 PDLIM4 0.34 6.46 0.34 3.75e-10 Breast cancer; CRC cis rs1178968 1.000 rs2353062 chr7:72740048 C/T cg25889504 chr7:72793014 NA 0.52 6.0 0.31 5.19e-9 Triglyceride levels; CRC trans rs2303319 0.504 rs66761688 chr2:162578911 T/C cg12500891 chr11:57225987 NA -0.67 -5.97 -0.31 6.24e-9 Cognitive function; CRC cis rs4276421 0.577 rs10054424 chr5:45748871 A/T cg07796823 chr5:45696928 HCN1 0.7 6.28 0.33 1.07e-9 P wave duration; CRC trans rs9545047 0.716 rs9545061 chr13:79884830 G/A cg07061582 chr15:90234082 PEX11A;WDR93 0.42 6.07 0.32 3.47e-9 Schizophrenia; CRC cis rs6754311 0.731 rs12988076 chr2:136569848 C/A cg15123519 chr2:136567270 LCT 0.33 6.39 0.33 5.65e-10 Mosquito bite size; CRC trans rs7267979 1.000 rs6050542 chr20:25318879 T/C cg17903999 chr18:56338584 MALT1 0.42 6.91 0.36 2.48e-11 Liver enzyme levels (alkaline phosphatase); CRC cis rs7552404 0.727 rs61770533 chr1:76306490 C/G cg03433033 chr1:76189801 ACADM 0.71 9.35 0.46 1.44e-18 Blood metabolite levels;Acylcarnitine levels; CRC cis rs9409565 0.821 rs9299419 chr9:97066584 C/T cg04523069 chr9:97136363 HIATL1 -0.39 -6.03 -0.32 4.33e-9 Colorectal cancer (alcohol consumption interaction); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg02499576 chr20:44601037 ZNF335 0.51 7.15 0.37 5.66e-12 Response to antipsychotic treatment; CRC cis rs9682041 0.696 rs16855034 chr3:170097842 C/G cg11886554 chr3:170076028 SKIL 0.69 8.26 0.41 3.53e-15 Glomerular filtration rate in non diabetics (creatinine);Glomerular filtration rate (creatinine); CRC cis rs9916302 0.904 rs8079355 chr17:37473018 G/A cg15445000 chr17:37608096 MED1 -0.42 -9.22 -0.45 3.61e-18 Glomerular filtration rate (creatinine); CRC cis rs7811142 0.943 rs67196635 chr7:100025564 T/C cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.76 10.89 0.51 8.98e-24 Platelet count; CRC cis rs7246657 0.943 rs10420430 chr19:37894194 C/G cg23950597 chr19:37808831 NA -0.54 -6.53 -0.34 2.49e-10 Coronary artery calcification; CRC cis rs96067 0.711 rs272811 chr1:36634414 G/A cg24686825 chr1:36642396 MAP7D1 -0.51 -6.68 -0.35 1.03e-10 Corneal structure; CRC cis rs6541297 0.941 rs6690424 chr1:230278892 C/T cg05784532 chr1:230284198 GALNT2 0.44 6.19 0.32 1.75e-9 Coronary artery disease; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg01105557 chr1:15931098 NA -0.38 -6.17 -0.32 2.03e-9 Liver disease severity in Alagille syndrome; CRC trans rs9747201 0.963 rs4789729 chr17:80146089 G/A cg07393940 chr7:158741817 NA 0.51 7.4 0.38 1.15e-12 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs921968 0.541 rs55996799 chr2:219558193 C/G cg02176678 chr2:219576539 TTLL4 -0.61 -9.64 -0.47 1.6e-19 Mean corpuscular hemoglobin concentration; CRC cis rs514406 0.929 rs1672909 chr1:53340824 A/G cg08859206 chr1:53392774 SCP2 -0.43 -6.74 -0.35 6.95e-11 Monocyte count; CRC cis rs1008375 0.966 rs2302393 chr4:17654341 G/A cg02297831 chr4:17616191 MED28 0.47 6.21 0.32 1.61e-9 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs7647973 0.600 rs12631989 chr3:49273996 C/T cg20833759 chr3:49053208 WDR6;DALRD3 0.39 6.37 0.33 6.35e-10 Menarche (age at onset); CRC cis rs992157 0.710 rs10167446 chr2:219056866 A/G cg04731861 chr2:219085781 ARPC2 -0.33 -7.07 -0.36 9.07e-12 Colorectal cancer; CRC cis rs644799 0.931 rs496305 chr11:95567035 C/T cg03916912 chr11:95522834 CEP57;FAM76B 0.96 18.45 0.71 1.13e-52 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs1552244 1.000 rs17032283 chr3:10081545 C/G cg18598329 chr3:10140678 FANCD2;C3orf24 -0.9 -12.1 -0.55 3.99e-28 Alzheimer's disease; CRC cis rs2739330 0.828 rs2877178 chr22:24251517 C/T cg10150615 chr22:24372951 LOC391322 -0.64 -9.66 -0.47 1.34e-19 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs7613875 0.663 rs6762477 chr3:50093209 G/A cg05623727 chr3:50126028 RBM5 -0.6 -10.34 -0.5 7.11e-22 Body mass index; CRC cis rs2295359 0.824 rs11209003 chr1:67601132 G/T cg17031739 chr1:67600172 NA 0.51 7.98 0.4 2.45e-14 Psoriasis; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg22476295 chr7:559000 PDGFA 0.43 6.28 0.33 1.1e-9 Intelligence (multi-trait analysis); CRC cis rs561341 0.941 rs2470236 chr17:30304940 G/C cg12193833 chr17:30244370 NA -0.62 -8.01 -0.4 2e-14 Hip circumference adjusted for BMI; CRC cis rs7647973 0.626 rs4855849 chr3:49653378 A/G cg13072238 chr3:49761600 GMPPB -0.51 -5.86 -0.31 1.15e-8 Menarche (age at onset); CRC cis rs2645694 0.651 rs2703144 chr4:77830505 C/G cg18351406 chr4:77819688 ANKRD56 0.51 7.6 0.39 3.1400000000000003e-13 Emphysema distribution in smoking; CRC cis rs72945132 0.882 rs58039907 chr11:70183336 C/T cg00319359 chr11:70116639 PPFIA1 0.65 7.24 0.37 3.14e-12 Coronary artery disease; CRC cis rs3806843 0.766 rs2251860 chr5:140048209 T/C cg19875535 chr5:140030758 IK -0.55 -8.85 -0.44 5.44e-17 Depressive symptoms (multi-trait analysis); CRC cis rs4561483 0.801 rs33631 chr16:11995387 G/C cg08843971 chr16:11963173 GSPT1 -0.63 -9.7 -0.47 9.57e-20 Testicular germ cell tumor; CRC cis rs826838 1.000 rs7975243 chr12:38849220 C/T cg26384229 chr12:38710491 ALG10B 0.76 10.48 0.5 2.31e-22 Heart rate; CRC cis rs644799 0.544 rs525087 chr11:95632266 G/A cg03916912 chr11:95522834 CEP57;FAM76B 0.66 10.78 0.51 2.15e-23 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs514406 0.708 rs546334 chr1:53326210 T/C cg24675658 chr1:53192096 ZYG11B -0.68 -10.13 -0.49 3.52e-21 Monocyte count; CRC cis rs2836974 0.932 rs73221193 chr21:40554693 C/T cg11644478 chr21:40555479 PSMG1 0.82 12.49 0.57 1.43e-29 Cognitive function; CRC cis rs4604732 0.642 rs6426252 chr1:247639887 G/T cg02104434 chr1:247694406 LOC148824;OR2C3 0.39 6.38 0.33 6.04e-10 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CRC cis rs798554 0.797 rs1182184 chr7:2872446 G/A cg04166393 chr7:2884313 GNA12 0.53 7.21 0.37 3.92e-12 Height; CRC cis rs155076 0.625 rs4769159 chr13:21881978 A/C cg06138931 chr13:21896616 NA 0.56 7.14 0.37 6.03e-12 White matter hyperintensity burden; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg11192808 chr8:101170185 SPAG1 -0.41 -6.1 -0.32 2.97e-9 Myopia (pathological); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg24594819 chr4:105416480 NA 0.41 6.03 0.32 4.33e-9 Liver disease severity in Alagille syndrome; CRC cis rs834811 0.831 rs834810 chr7:135879825 T/C cg01726295 chr7:135938950 NA 0.45 7.75 0.39 1.19e-13 Post-traumatic stress disorder; CRC cis rs2839186 0.558 rs2968 chr21:47608580 C/T cg11766577 chr21:47581405 C21orf56 0.37 5.88 0.31 1.02e-8 Testicular germ cell tumor; CRC cis rs9814567 0.928 rs6768323 chr3:134268737 A/C cg06109529 chr3:134205091 CEP63;ANAPC13 0.82 12.06 0.55 5.69e-28 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs6662572 0.855 rs7517418 chr1:46252418 G/A cg08644498 chr1:46502608 NA -0.46 -7.38 -0.38 1.29e-12 Blood protein levels; CRC cis rs9309711 0.621 rs11127428 chr2:3471146 T/C cg10845886 chr2:3471009 TTC15 -0.39 -6.02 -0.32 4.59e-9 Neurofibrillary tangles; CRC cis rs910316 0.967 rs2010678 chr14:75567178 C/T cg03030879 chr14:75389066 RPS6KL1 -0.46 -7.31 -0.37 2.08e-12 Height; CRC cis rs3762318 0.951 rs12095536 chr1:67600142 T/C cg17031739 chr1:67600172 NA 0.49 5.98 0.31 5.84e-9 Leprosy; CRC cis rs524281 0.861 rs7931544 chr11:65917034 C/T cg16950941 chr11:66035639 RAB1B -0.6 -7.43 -0.38 9.29e-13 Electroencephalogram traits; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg00556514 chr3:38066524 PLCD1 0.46 7.22 0.37 3.65e-12 Liver disease severity in Alagille syndrome; CRC cis rs7216064 0.601 rs35453056 chr17:66039668 A/G cg12091567 chr17:66097778 LOC651250 0.92 13.95 0.61 4.4e-35 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CRC cis rs11608355 0.960 rs10774691 chr12:109859830 C/T cg19025524 chr12:109796872 NA -0.47 -6.72 -0.35 8e-11 Neuroticism; CRC cis rs8044868 0.586 rs7199261 chr16:72082788 A/G cg23815491 chr16:72088622 HP 0.5 7.23 0.37 3.35e-12 Body mass index (change over time) in cancer or chronic obstructive pulmonary disease;Body mass index (change over time) in cancer; CRC cis rs854765 0.647 rs854790 chr17:18028318 C/G cg16928487 chr17:17741425 SREBF1 -0.44 -7.37 -0.38 1.39e-12 Total body bone mineral density; CRC cis rs10504229 1.000 rs66840104 chr8:58190001 C/T cg02290350 chr8:58132656 NA -0.42 -5.96 -0.31 6.62e-9 Developmental language disorder (linguistic errors); CRC cis rs10504229 0.593 rs116916898 chr8:57984958 G/A cg02725872 chr8:58115012 NA -0.56 -6.76 -0.35 6.26e-11 Developmental language disorder (linguistic errors); CRC trans rs2292864 1.000 rs2292864 chr17:45367681 C/T cg03564338 chr16:50585384 NKD1 0.62 6.01 0.31 4.88e-9 Left atrial antero-posterior diameter; CRC cis rs9635542 0.833 rs60006336 chr16:5007563 C/T cg06510647 chr16:5006106 NA -0.61 -6.67 -0.34 1.1e-10 Lung cancer (asbestos exposure interaction);Cancer; CRC cis rs561341 0.883 rs4450460 chr17:30201309 C/T cg23018236 chr17:30244563 NA 0.52 6.69 0.35 9.75e-11 Hip circumference adjusted for BMI; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg00026974 chr17:42298151 UBTF -0.42 -6.07 -0.32 3.54e-9 Myopia (pathological); CRC cis rs9733 0.596 rs6669369 chr1:150695892 C/T cg15448220 chr1:150897856 SETDB1 0.45 6.41 0.33 5.09e-10 Tonsillectomy; CRC cis rs7811142 0.830 rs6948685 chr7:99970188 C/T cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.16 16.72 0.68 7.41e-46 Platelet count; CRC cis rs9916302 0.904 rs12952384 chr17:37669536 T/C cg15445000 chr17:37608096 MED1 0.43 9.59 0.47 2.25e-19 Glomerular filtration rate (creatinine); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg05889321 chr10:97416837 ALDH18A1 0.45 6.68 0.35 1.02e-10 Response to antipsychotic treatment; CRC trans rs10838798 0.523 rs11039593 chr11:48240112 A/G cg21153622 chr11:89784906 NA -0.49 -7.98 -0.4 2.5e-14 Height; CRC cis rs10927875 0.830 rs1763610 chr1:16335527 C/G cg24140574 chr1:16342155 HSPB7 -0.42 -5.83 -0.31 1.35e-8 Dilated cardiomyopathy; CRC cis rs9399135 0.967 rs4896120 chr6:135293512 C/G cg22676075 chr6:135203613 NA 0.42 6.39 0.33 5.6e-10 Red blood cell count; CRC cis rs3857536 0.740 rs9354391 chr6:66890183 C/T cg07460842 chr6:66804631 NA 0.44 5.86 0.31 1.11e-8 Blood trace element (Cu levels); CRC cis rs9649213 0.593 rs3801256 chr7:97992095 C/G cg21770322 chr7:97807741 LMTK2 0.52 8.47 0.42 8.07e-16 Prostate cancer (SNP x SNP interaction); CRC cis rs7680126 0.596 rs4698030 chr4:10315850 A/G cg11266682 chr4:10021025 SLC2A9 -0.4 -6.04 -0.32 4.17e-9 Urate levels in lean individuals;Urate levels in overweight individuals;Urate levels in obese individuals; CRC cis rs6747952 0.899 rs1374387 chr2:239085687 A/C cg17459225 chr2:239074497 NA 0.46 7.96 0.4 2.91e-14 Mean corpuscular hemoglobin concentration; CRC trans rs561341 1.000 rs111454793 chr17:30319267 T/C cg27661571 chr11:113659931 NA -0.95 -10.99 -0.52 3.76e-24 Hip circumference adjusted for BMI; CRC cis rs652260 0.646 rs693941 chr19:7903851 C/T cg26014689 chr19:7917955 EVI5L -0.64 -10.53 -0.5 1.5e-22 Menarche (age at onset); CRC cis rs780096 0.526 rs12476704 chr2:27613031 C/A cg21248554 chr2:27665150 KRTCAP3 -0.33 -7.26 -0.37 2.79e-12 Total body bone mineral density; CRC cis rs9372498 0.536 rs9489477 chr6:118946192 T/G cg15382696 chr6:118971807 C6orf204 0.6 7.57 0.39 3.76e-13 Diastolic blood pressure; CRC cis rs4731207 0.596 rs115520589 chr7:124635877 A/G cg23710748 chr7:124431027 NA -0.39 -6.18 -0.32 1.86e-9 Cutaneous malignant melanoma; CRC cis rs11997175 0.646 rs12678266 chr8:33689254 A/G cg04338863 chr8:33670619 NA 0.44 6.95 0.36 1.93e-11 Body mass index; CRC cis rs9381040 0.599 rs2057001 chr6:41022947 A/G cg03644281 chr6:41068752 NFYA;LOC221442 -0.46 -6.62 -0.34 1.43e-10 Alzheimer's disease (late onset); CRC cis rs7660520 0.524 rs6839881 chr4:183729137 A/T cg12483801 chr4:183727862 NA 0.63 8.45 0.42 9.55e-16 Pediatric autoimmune diseases; CRC cis rs2050392 0.762 rs306587 chr10:30722908 G/C cg18806716 chr10:30721971 MAP3K8 -0.5 -7.47 -0.38 7.25e-13 Inflammatory bowel disease; CRC cis rs7829975 0.714 rs4841042 chr8:8664622 A/G cg06636001 chr8:8085503 FLJ10661 -0.58 -9.3 -0.46 1.96e-18 Mood instability; CRC cis rs2032447 0.714 rs199739 chr6:25960509 A/C cg03264133 chr6:25882463 NA -0.6 -8.53 -0.43 5.31e-16 Intelligence (multi-trait analysis); CRC cis rs4903604 0.560 rs4903605 chr14:78035619 C/T cg18872420 chr14:78023429 SPTLC2 0.37 6.18 0.32 1.91e-9 Gut microbiome composition (winter); CRC trans rs7800418 0.723 rs1029556 chr7:26588186 G/A cg14387656 chr2:233470847 EFHD1 0.46 6.37 0.33 6.36e-10 Cognitive function; CRC cis rs713587 0.521 rs35177510 chr2:25089594 C/A cg04586622 chr2:25135609 ADCY3 -0.56 -10.5 -0.5 1.94e-22 Body mass index in non-asthmatics; CRC cis rs2019137 0.560 rs7421852 chr2:113990261 G/A cg21482265 chr2:113992762 PAX8;LOC440839;LOC654433 0.62 9.24 0.45 3.16e-18 Lymphocyte counts; CRC cis rs4969178 0.965 rs4969179 chr17:76391454 A/C cg05887092 chr17:76393375 PGS1 0.56 10.41 0.5 4.15e-22 HDL cholesterol levels; CRC cis rs7944584 0.879 rs11039182 chr11:47346723 T/C cg20307385 chr11:47447363 PSMC3 0.75 9.19 0.45 4.46e-18 Fasting blood glucose;Fasting blood glucose (BMI interaction); CRC cis rs2243480 0.711 rs2460426 chr7:65623129 A/G cg12463550 chr7:65579703 CRCP -0.71 -6.52 -0.34 2.71e-10 Diabetic kidney disease; CRC cis rs2019137 0.560 rs10175462 chr2:113988492 G/A cg12889195 chr2:113992843 PAX8;LOC440839;LOC654433 0.63 9.82 0.48 3.89e-20 Lymphocyte counts; CRC cis rs7119 0.634 rs11635634 chr15:77863412 T/C cg10437265 chr15:77819839 NA -0.48 -7.9 -0.4 4.28e-14 Type 2 diabetes; CRC cis rs12824058 0.678 rs11614163 chr12:130814621 C/G cg26677194 chr12:130822605 PIWIL1 0.45 7.18 0.37 4.75e-12 Menopause (age at onset); CRC cis rs713477 1.000 rs28604440 chr14:55911324 C/T cg13175173 chr14:55914753 NA -0.47 -8.89 -0.44 4.09e-17 Pediatric bone mineral content (femoral neck); CRC cis rs9926296 0.682 rs258328 chr16:89730314 C/T cg01097406 chr16:89675127 NA 0.51 9.33 0.46 1.66e-18 Vitiligo; CRC cis rs1862618 0.671 rs2034244 chr5:56242774 T/C cg12311346 chr5:56204834 C5orf35 0.64 9.83 0.48 3.66e-20 Initial pursuit acceleration; CRC cis rs1223397 0.651 rs2439542 chr6:13311823 G/A cg20827128 chr6:13274284 PHACTR1 0.38 5.81 0.3 1.5e-8 Blood pressure; CRC cis rs4563143 0.675 rs56322221 chr19:29270349 A/T cg12667521 chr19:29218732 NA 0.5 7.55 0.38 4.25e-13 Methadone dose in opioid dependence; CRC cis rs561341 1.000 rs501957 chr17:30314504 C/T cg00745463 chr17:30367425 LRRC37B -0.85 -9.46 -0.46 6.1e-19 Hip circumference adjusted for BMI; CRC cis rs6964587 0.967 rs2282969 chr7:91583772 T/C cg17063962 chr7:91808500 NA -0.79 -13.76 -0.6 2.47e-34 Breast cancer; CRC cis rs8180040 0.764 rs12629262 chr3:47196580 C/T cg27129171 chr3:47204927 SETD2 0.68 11.12 0.52 1.36e-24 Colorectal cancer; CRC cis rs7618915 0.524 rs10433615 chr3:52638482 C/T cg15147215 chr3:52552868 STAB1 -0.62 -10.17 -0.49 2.64e-21 Bipolar disorder; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg10982358 chr1:51435615 CDKN2C 0.44 6.71 0.35 8.58e-11 Liver disease severity in Alagille syndrome; CRC cis rs11167764 1.000 rs7730511 chr5:141480418 T/C cg08523384 chr5:141488047 NDFIP1 -0.52 -8.49 -0.42 7.14e-16 Crohn's disease; CRC cis rs9910055 0.762 rs7213436 chr17:42252163 A/G cg13607699 chr17:42295918 UBTF -0.48 -6.42 -0.33 4.88e-10 Total body bone mineral density; CRC cis rs720844 0.748 rs16829034 chr2:149349581 C/T cg09247360 chr2:149335327 NA -0.59 -6.01 -0.31 4.95e-9 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs5758659 0.714 rs133373 chr22:42465788 G/A cg25452165 chr22:42524984 CYP2D6 0.44 6.51 0.34 2.8e-10 Cognitive function; CRC cis rs6952808 0.600 rs2895202 chr7:2131829 T/C cg21782813 chr7:2030301 MAD1L1 0.55 9.45 0.46 6.5e-19 Bipolar disorder and schizophrenia; CRC cis rs6088590 0.561 rs6059918 chr20:33150503 C/T cg08999081 chr20:33150536 PIGU 0.64 12.35 0.56 4.96e-29 Coronary artery disease; CRC cis rs6570726 1.000 rs386678 chr6:145869010 A/G cg23711669 chr6:146136114 FBXO30 0.67 11.37 0.53 1.78e-25 Lobe attachment (rater-scored or self-reported); CRC cis rs16975963 0.843 rs241935 chr19:38293963 A/C cg15135657 chr19:38346511 NA 0.43 5.83 0.31 1.35e-8 Longevity; CRC cis rs868036 1.000 rs1026735 chr15:68101700 A/G cg05925327 chr15:68127851 NA -0.31 -6.0 -0.31 5.18e-9 Restless legs syndrome; CRC cis rs72781680 0.611 rs78861366 chr2:24354428 A/G cg06627628 chr2:24431161 ITSN2 -0.52 -6.06 -0.32 3.64e-9 Lymphocyte counts; CRC cis rs10788264 0.621 rs7907952 chr10:124056774 C/T cg09507567 chr10:124027408 NA -0.34 -7.43 -0.38 9.36e-13 Total body bone mineral density; CRC cis rs644799 0.662 rs35793328 chr11:95490896 G/T cg25622487 chr11:95524042 FAM76B;CEP57 0.58 7.84 0.4 6.12e-14 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs2985684 1.000 rs8014170 chr14:50071694 C/G cg04989706 chr14:50066350 PPIL5 -0.6 -8.19 -0.41 5.67e-15 Carotid intima media thickness; CRC cis rs873946 0.504 rs3793681 chr10:134564451 T/C cg27286337 chr10:134555280 INPP5A 0.68 8.87 0.44 4.71e-17 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CRC cis rs3785574 0.927 rs2727313 chr17:61961914 A/G cg06873352 chr17:61820015 STRADA 0.45 7.12 0.37 6.67e-12 Height; CRC cis rs763121 0.853 rs3747172 chr22:39067524 A/G cg06022373 chr22:39101656 GTPBP1 0.79 12.54 0.57 9.5e-30 Menopause (age at onset); CRC cis rs1577917 0.958 rs12196175 chr6:86779370 C/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.58 -7.07 -0.36 9.19e-12 Response to antipsychotic treatment; CRC cis rs1865760 0.566 rs3752419 chr6:26027433 C/T cg17691542 chr6:26056736 HIST1H1C 0.55 8.32 0.42 2.31e-15 Height; CRC cis rs17376456 0.825 rs6877030 chr5:93201841 C/A cg21475434 chr5:93447410 FAM172A 0.75 7.34 0.37 1.73e-12 Diabetic retinopathy; CRC cis rs6867032 1.000 rs2129471 chr5:2016236 C/G cg26168224 chr5:2018326 NA 0.99 18.25 0.71 6.79e-52 Gut microbiome composition (winter); CRC cis rs72627509 0.857 rs55762216 chr4:57765731 G/C cg26694713 chr4:57773883 REST 0.49 5.68 0.3 2.94e-8 Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); CRC cis rs4713118 0.868 rs2893928 chr6:27738430 C/A cg02683197 chr6:28174875 NA 0.7 7.39 0.38 1.24e-12 Parkinson's disease; CRC cis rs3785574 0.962 rs2597632 chr17:61894739 A/T cg22520471 chr17:61851767 DDX42;CCDC47 0.47 6.37 0.33 6.35e-10 Height; CRC trans rs916888 0.773 rs199457 chr17:44795469 C/T cg23590916 chr17:43697445 MGC57346 0.71 7.24 0.37 3.1e-12 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs67311347 0.577 rs2371129 chr3:40248393 C/T cg09455208 chr3:40491958 NA -0.34 -7.11 -0.36 7.29e-12 Renal cell carcinoma; CRC trans rs948562 1.000 rs12365551 chr11:58358368 T/C cg26660744 chr1:1573181 CDK11B 0.53 6.19 0.32 1.83e-9 Lymphoma; CRC cis rs9372498 0.505 rs62424173 chr6:118780507 C/G cg24463073 chr6:118973353 C6orf204 0.52 6.84 0.35 3.84e-11 Diastolic blood pressure; CRC cis rs7914558 0.966 rs10786725 chr10:104682357 T/C cg15744005 chr10:104629667 AS3MT -0.35 -7.51 -0.38 5.75e-13 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC trans rs11764590 0.671 rs3800872 chr7:2110272 C/G cg11693508 chr17:37793320 STARD3 0.61 7.58 0.39 3.44e-13 Neuroticism; CRC cis rs2012796 0.704 rs57670850 chr14:81841577 C/T cg02996355 chr14:81879375 NA 0.61 9.31 0.46 1.87e-18 Night sleep phenotypes; CRC cis rs8060686 0.545 rs117751972 chr16:68171968 C/T cg26727032 chr16:67993705 SLC12A4 -0.57 -6.1 -0.32 3.03e-9 HDL cholesterol;Metabolic syndrome; CRC cis rs7412746 0.646 rs10399947 chr1:150861960 G/A cg17724175 chr1:150552817 MCL1 0.4 6.1 0.32 2.98e-9 Melanoma; CRC cis rs597539 0.652 rs627731 chr11:68698663 A/C cg06028808 chr11:68637592 NA 0.36 5.65 0.3 3.57e-8 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs67478160 0.595 rs2295146 chr14:104199356 C/T cg08213375 chr14:104286397 PPP1R13B 0.6 11.68 0.54 1.32e-26 Schizophrenia; CRC cis rs7584330 0.504 rs11890307 chr2:238434705 A/G cg14458575 chr2:238380390 NA 0.52 6.86 0.35 3.51e-11 Prostate cancer; CRC cis rs77861329 1.000 rs164638 chr3:52207886 T/G cg08692210 chr3:52188851 WDR51A 0.85 7.95 0.4 2.99e-14 Macrophage inflammatory protein 1b levels; CRC cis rs9747201 1.000 rs57405744 chr17:80177465 A/G cg14673194 chr17:80132900 CCDC57 -0.48 -6.02 -0.32 4.56e-9 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs875971 0.825 rs59466412 chr7:65565358 A/G cg00343986 chr7:65444356 GUSB -0.44 -6.31 -0.33 9.16e-10 Aortic root size; CRC cis rs7312933 0.533 rs11181499 chr12:42818761 A/G cg11827402 chr12:42719852 PPHLN1;ZCRB1 0.67 9.72 0.47 8.72e-20 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CRC cis rs2811415 0.597 rs3774796 chr3:127780473 C/T cg13719885 chr3:127795394 NA 0.4 6.08 0.32 3.33e-9 Lung function (FEV1/FVC); CRC cis rs7617773 0.817 rs3731555 chr3:48206102 G/A cg11946769 chr3:48343235 NME6 0.72 9.79 0.47 4.95e-20 Coronary artery disease; CRC cis rs2014572 0.967 rs10421632 chr19:57764770 G/A cg12963866 chr19:57752005 ZNF805 -0.41 -6.09 -0.32 3.15e-9 Hyperactive-impulsive symptoms; CRC cis rs7552404 0.883 rs2185436 chr1:76203783 A/G cg03433033 chr1:76189801 ACADM 0.91 13.76 0.6 2.34e-34 Blood metabolite levels;Acylcarnitine levels; CRC cis rs1552244 0.554 rs2272118 chr3:10049287 T/C cg08888203 chr3:10149979 C3orf24 0.48 7.33 0.37 1.74e-12 Alzheimer's disease; CRC trans rs3942852 0.806 rs10769316 chr11:48119745 C/G cg03929089 chr4:120376271 NA -0.56 -7.25 -0.37 2.95e-12 Acute lymphoblastic leukemia (childhood); CRC cis rs2760061 0.583 rs708118 chr1:228201801 A/G cg02753203 chr1:228287806 NA -0.78 -12.49 -0.57 1.51e-29 Diastolic blood pressure; CRC cis rs875971 0.660 rs6460308 chr7:66084740 T/C cg25985355 chr7:65971099 NA 0.32 5.62 0.3 4.16e-8 Aortic root size; CRC cis rs728616 0.681 rs36023925 chr10:81906846 T/C cg11900509 chr10:81946545 ANXA11 -0.71 -8.0 -0.4 2.21e-14 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs11098499 0.954 rs59394118 chr4:120295551 A/G cg24375607 chr4:120327624 NA 0.5 7.74 0.39 1.26e-13 Corneal astigmatism; CRC cis rs4965869 0.806 rs34257513 chr15:101993017 G/A cg12371147 chr15:101978424 PCSK6 -0.43 -5.99 -0.31 5.43e-9 Platelet-derived growth factor BB levels; CRC cis rs34172651 0.917 rs1075987 chr16:24794957 G/A cg06028605 chr16:24865363 SLC5A11 0.39 7.26 0.37 2.9e-12 Intelligence (multi-trait analysis); CRC cis rs7811142 0.667 rs3873746 chr7:99935097 G/A cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.81 10.75 0.51 2.74e-23 Platelet count; CRC cis rs9462027 0.628 rs9462020 chr6:34751265 T/C cg07306190 chr6:34760872 UHRF1BP1 -0.35 -6.23 -0.33 1.4e-9 Systemic lupus erythematosus; CRC cis rs9902453 0.933 rs7216494 chr17:28502651 C/G cg26525008 chr17:28256777 EFCAB5;SSH2 0.6 9.43 0.46 7.7e-19 Coffee consumption (cups per day); CRC cis rs501120 1.000 rs479596 chr10:44760473 C/T cg09554077 chr10:44749378 NA 0.78 11.84 0.55 3.45e-27 Coronary artery disease;Coronary heart disease; CRC cis rs7586879 0.828 rs12986610 chr2:25106265 A/G cg22495460 chr2:25135724 ADCY3 0.87 14.76 0.63 3.34e-38 Body mass index; CRC trans rs7615952 0.558 rs7641353 chr3:125339879 T/C cg08546805 chr12:8549446 NA -0.43 -6.52 -0.34 2.65e-10 Blood pressure (smoking interaction); CRC trans rs7613875 0.620 rs34312088 chr3:50032133 C/T cg21659725 chr3:3221576 CRBN 0.44 6.43 0.33 4.45e-10 Body mass index; CRC cis rs853679 0.517 rs9368554 chr6:28082711 T/C cg21251018 chr6:28226885 NKAPL 0.48 6.19 0.32 1.84e-9 Depression; CRC cis rs711830 0.931 rs6755766 chr2:177043205 T/C cg13092806 chr2:177043255 NA 0.75 9.53 0.47 3.51e-19 Serous invasive ovarian cancer;Epithelial ovarian cancer;Invasive epithelial ovarian cancer;Mucinous ovarian carcinoma;Low-grade serous and serous borderline ovarian cancer;Serous borderline ovarian cancer;High-grade serous ovarian cancer; CRC cis rs7274811 0.711 rs291669 chr20:31945364 C/T cg03904042 chr20:32255491 NECAB3;C20orf134 0.39 6.06 0.32 3.78e-9 Height; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg03128421 chr2:55647401 CCDC88A 0.39 6.06 0.32 3.64e-9 Liver disease severity in Alagille syndrome; CRC cis rs41271473 0.526 rs12353961 chr1:228738252 G/C cg16512390 chr1:228756714 NA 0.64 6.8 0.35 4.93e-11 Chronic lymphocytic leukemia; CRC cis rs6761276 0.899 rs6759676 chr2:113836348 A/G cg09040174 chr2:113837401 NA -0.64 -10.19 -0.49 2.26e-21 Protein quantitative trait loci; CRC cis rs13090388 1 rs13090388 chr3:49391082 C/T cg07274523 chr3:49395745 GPX1 0.45 5.99 0.31 5.5e-9 Intelligence (multi-trait analysis);Educational attainment (years of education); CRC cis rs11031096 0.505 rs10835743 chr11:4226692 C/T cg18678763 chr11:4115507 RRM1 -0.37 -5.61 -0.3 4.26e-8 Mean corpuscular volume;Mean corpuscular hemoglobin; CRC cis rs2075371 1.000 rs2075373 chr7:133984683 A/C cg20476274 chr7:133979776 SLC35B4 0.8 14.55 0.63 2.29e-37 Mean platelet volume; CRC trans rs7301826 0.627 rs7315707 chr12:131272819 A/G cg00959118 chr1:169455055 SLC19A2 0.49 5.98 0.31 5.79e-9 Plasma plasminogen activator levels; CRC trans rs7647973 0.593 rs59684465 chr3:49874246 C/T cg21659725 chr3:3221576 CRBN 0.66 7.31 0.37 2e-12 Menarche (age at onset); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg16004202 chr4:159689901 FNIP2 0.4 6.54 0.34 2.32e-10 Liver disease severity in Alagille syndrome; CRC cis rs9303401 0.614 rs17175663 chr17:57108437 G/C cg02118635 chr17:56770003 RAD51C;TEX14 0.77 9.24 0.45 3.17e-18 Cognitive test performance; CRC cis rs9733 0.565 rs11804276 chr1:150685761 T/A cg18016565 chr1:150552671 MCL1 0.45 6.52 0.34 2.57e-10 Tonsillectomy; CRC trans rs60843830 0.633 rs1078763 chr2:113763 A/G cg11347411 chr7:150020925 ACTR3C;LRRC61 -0.44 -6.53 -0.34 2.42e-10 Spherical equivalent (joint analysis main effects and education interaction); CRC cis rs7917772 0.502 rs2296583 chr10:104244322 T/G cg22532475 chr10:104410764 TRIM8 -0.36 -6.5 -0.34 2.95e-10 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC cis rs9372498 0.536 rs62422221 chr6:118925581 T/C cg15382696 chr6:118971807 C6orf204 0.56 6.89 0.36 2.84e-11 Diastolic blood pressure; CRC cis rs1005277 0.541 rs2505193 chr10:38394638 G/C cg00409905 chr10:38381863 ZNF37A -0.68 -11.33 -0.53 2.33e-25 Extrinsic epigenetic age acceleration; CRC cis rs747650 0.859 rs4567413 chr11:47232184 A/G cg19486271 chr11:47235900 DDB2 -0.52 -7.78 -0.39 9.22e-14 Acne (severe); CRC cis rs9393777 0.513 rs9393737 chr6:26617306 A/G cg12292205 chr6:26970375 C6orf41 0.61 6.72 0.35 8.1e-11 Intelligence (multi-trait analysis); CRC cis rs2949837 0.581 rs1852210 chr7:45994256 C/T cg23193639 chr7:45961078 IGFBP3 0.39 6.54 0.34 2.42e-10 Sitting height ratio; CRC cis rs13108904 0.539 rs13135102 chr4:1330983 A/C cg24560729 chr4:1342394 KIAA1530 0.38 6.22 0.32 1.5e-9 Obesity-related traits; CRC cis rs2290405 0.527 rs4690332 chr4:910520 C/T cg03286735 chr4:906491 GAK 0.27 5.92 0.31 7.93e-9 Systemic sclerosis; CRC cis rs7412746 0.634 rs2124952 chr1:150923774 T/A cg18016565 chr1:150552671 MCL1 0.42 6.06 0.32 3.8e-9 Melanoma; CRC trans rs561341 1.000 rs757009 chr17:30243937 A/G cg27661571 chr11:113659931 NA -0.58 -7.29 -0.37 2.38e-12 Hip circumference adjusted for BMI; CRC cis rs2354432 0.556 rs72710311 chr1:146698256 A/G cg25205988 chr1:146714368 CHD1L -1.16 -9.44 -0.46 7.24e-19 Mitochondrial DNA levels; CRC trans rs1814175 0.519 rs10839291 chr11:49514321 G/A cg11707556 chr5:10655725 ANKRD33B 0.47 7.61 0.39 2.89e-13 Height; CRC cis rs4481887 0.639 rs10749644 chr1:248414587 A/C cg13385794 chr1:248469461 NA 0.34 5.98 0.31 5.81e-9 Common traits (Other); CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg23839113 chr7:30634781 GARS 0.45 6.38 0.33 5.87e-10 Anxiety disorder; CRC cis rs9341808 0.519 rs684251 chr6:80967337 G/A cg08355045 chr6:80787529 NA -0.35 -5.71 -0.3 2.58e-8 Sitting height ratio; CRC cis rs7259376 0.807 rs7254434 chr19:22500033 G/A cg02657401 chr19:22469223 NA -0.36 -7.97 -0.4 2.69e-14 Menopause (age at onset); CRC cis rs9393692 0.905 rs7450556 chr6:26299900 C/T cg13736514 chr6:26305472 NA -0.62 -11.4 -0.53 1.32e-25 Educational attainment; CRC cis rs780096 0.526 rs809058 chr2:27616790 T/C cg21248554 chr2:27665150 KRTCAP3 -0.31 -7.13 -0.37 6.58e-12 Total body bone mineral density; CRC cis rs7412746 0.587 rs11204722 chr1:150730184 A/C cg18016565 chr1:150552671 MCL1 -0.44 -6.02 -0.32 4.58e-9 Melanoma; CRC cis rs7429990 0.813 rs7627568 chr3:48093052 A/T cg11946769 chr3:48343235 NME6 -0.44 -5.65 -0.3 3.49e-8 Educational attainment (years of education); CRC cis rs4423214 0.592 rs11233933 chr11:71210070 C/T cg05163923 chr11:71159392 DHCR7 -0.57 -5.93 -0.31 7.49e-9 Vitamin D levels; CRC cis rs4819052 0.851 rs4819044 chr21:46660118 G/A cg02159808 chr21:46707872 POFUT2;LOC642852 0.49 6.44 0.33 4.36e-10 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs2842992 0.789 rs9355748 chr6:160194882 G/A cg16489826 chr6:160211363 TCP1;MRPL18 0.49 6.27 0.33 1.13e-9 Age-related macular degeneration (geographic atrophy); CRC cis rs4838594 0.715 rs11101340 chr10:49682402 C/T cg17291251 chr10:49678358 ARHGAP22 0.37 5.71 0.3 2.51e-8 Daytime sleep phenotypes; CRC cis rs9611565 0.921 rs5751080 chr22:41736267 A/G cg03806693 chr22:41940476 POLR3H -0.65 -9.51 -0.46 4.3e-19 Vitiligo; CRC cis rs9916302 0.904 rs7503069 chr17:37697128 C/G cg03013999 chr17:37608204 MED1 0.46 7.14 0.37 5.87e-12 Glomerular filtration rate (creatinine); CRC cis rs4664308 0.935 rs4520994 chr2:160937750 G/A cg03641300 chr2:160917029 PLA2R1 -0.73 -11.66 -0.54 1.59e-26 Idiopathic membranous nephropathy; CRC cis rs611744 0.583 rs1448148 chr8:109333074 T/A cg18478394 chr8:109455254 TTC35 0.46 6.97 0.36 1.76e-11 Dupuytren's disease; CRC cis rs2404602 0.569 rs283793 chr15:76774752 G/A cg23625390 chr15:77176239 SCAPER 0.72 10.66 0.51 5.48e-23 Blood metabolite levels; CRC trans rs1005277 0.579 rs1740749 chr10:38521646 A/G cg11292332 chr7:45801988 SEPT13 -0.39 -7.05 -0.36 1.05e-11 Extrinsic epigenetic age acceleration; CRC cis rs11711311 0.955 rs2124105 chr3:113406003 G/A cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.51 -6.63 -0.34 1.4e-10 IgG glycosylation; CRC trans rs2243480 1.000 rs427044 chr7:65508545 G/A cg10756647 chr7:56101905 PSPH 0.77 7.97 0.4 2.7e-14 Diabetic kidney disease; CRC cis rs6545883 0.862 rs11691734 chr2:61702466 C/T cg15711740 chr2:61764176 XPO1 -0.43 -5.67 -0.3 3.16e-8 Tuberculosis; CRC cis rs3751196 0.808 rs1550208 chr12:104210240 A/G cg02344784 chr12:104178138 NT5DC3 0.68 6.91 0.36 2.49e-11 Sense of smell; CRC cis rs7580658 0.895 rs9636237 chr2:128076022 T/C cg09760422 chr2:128146352 NA -0.3 -5.81 -0.3 1.49e-8 Protein C levels; CRC cis rs9346649 0.606 rs7750135 chr6:168490841 C/A cg02770688 chr6:168491649 NA 0.6 8.69 0.43 1.74e-16 Venous thromboembolism adjusted for sickle cell variant rs77121243-T; CRC trans rs587242 1.000 rs12744063 chr1:96898431 T/C cg10631902 chr5:14652156 NA 0.44 6.74 0.35 7.14e-11 Body mass index (joint analysis main effects and physical activity interaction);Body mass index in physically inactive individuals;Body mass index; CRC trans rs1455244 0.700 rs7229302 chr18:11508904 G/T cg03111951 chr1:180123704 QSOX1 0.42 6.45 0.34 4.11e-10 Schizophrenia; CRC cis rs10504229 0.906 rs73607869 chr8:58172665 G/T cg22535103 chr8:58192502 C8orf71 -0.82 -12.27 -0.56 9.63e-29 Developmental language disorder (linguistic errors); CRC cis rs76419734 0.558 rs10030620 chr4:106574536 A/G cg24545054 chr4:106630052 GSTCD;INTS12 0.59 6.84 0.35 3.84e-11 Post bronchodilator FEV1; CRC cis rs2836974 0.897 rs1984022 chr21:40596085 G/A cg06238570 chr21:40685208 BRWD1 0.78 10.89 0.51 8.51e-24 Cognitive function; CRC cis rs2742417 0.603 rs2064063 chr3:45759924 T/A cg04837898 chr3:45731254 SACM1L -0.49 -7.88 -0.4 4.7e-14 Response to anti-depressant treatment in major depressive disorder; CRC cis rs1552244 0.882 rs13074282 chr3:10024699 T/G cg02579736 chr3:10068473 FANCD2;CIDECP 0.93 11.94 0.55 1.55e-27 Alzheimer's disease; CRC cis rs7267979 0.844 rs6083824 chr20:25363057 G/A cg24626310 chr20:25276739 ABHD12;PYGB -0.34 -5.69 -0.3 2.75e-8 Liver enzyme levels (alkaline phosphatase); CRC cis rs10971721 0.822 rs56253239 chr9:33860066 A/G cg13495928 chr9:33750294 PRSS3 0.55 5.93 0.31 7.7e-9 Body mass index; CRC cis rs17767392 0.881 rs7140501 chr14:72023175 C/G cg13720639 chr14:72061746 SIPA1L1 0.56 7.11 0.37 7.05e-12 Mitral valve prolapse; CRC cis rs965469 0.779 rs6051772 chr20:3328654 C/G cg25506879 chr20:3388711 C20orf194 -0.37 -5.76 -0.3 1.91e-8 IFN-related cytopenia; CRC cis rs561341 1.000 rs8077092 chr17:30281992 T/C cg19193384 chr17:30244184 NA -0.53 -6.61 -0.34 1.52e-10 Hip circumference adjusted for BMI; CRC cis rs7517126 1.000 rs13375236 chr1:196842271 A/G cg13682187 chr1:196946512 CFHR5 0.37 6.31 0.33 8.81e-10 Blood protein levels; CRC cis rs1215050 0.740 rs783929 chr4:98972495 T/A cg05340658 chr4:99064831 C4orf37 -0.48 -7.43 -0.38 9.29e-13 Waist-to-hip ratio adjusted for body mass index; CRC cis rs7020830 0.898 rs6476617 chr9:37200103 G/A cg14294708 chr9:37120828 ZCCHC7 1.07 21.46 0.76 1.67e-64 Schizophrenia; CRC cis rs519973 0.687 rs542887 chr3:187650907 C/T cg10168494 chr3:187635183 NA 0.32 5.61 0.3 4.23e-8 Allergic disease (asthma, hay fever or eczema); CRC cis rs7605827 0.897 rs4668899 chr2:15511575 C/A cg19274914 chr2:15703543 NA 0.38 5.8 0.3 1.59e-8 Educational attainment (years of education); CRC cis rs11122272 0.735 rs910822 chr1:231498721 G/A cg06096015 chr1:231504339 EGLN1 0.39 6.07 0.32 3.59e-9 Hemoglobin concentration; CRC cis rs17065868 0.764 rs9533856 chr13:45029865 C/T cg10246903 chr13:45222710 NA 0.54 5.69 0.3 2.79e-8 Antineutrophil cytoplasmic antibody-associated vasculitis; CRC cis rs9372498 0.536 rs9320660 chr6:118956827 A/T cg22561889 chr6:118971681 C6orf204 0.52 6.58 0.34 1.91e-10 Diastolic blood pressure; CRC cis rs3800461 0.509 rs73407707 chr6:34476644 T/G cg14254433 chr6:34482411 PACSIN1 -0.79 -8.42 -0.42 1.15e-15 Chronic lymphocytic leukemia; CRC cis rs7412746 0.611 rs111905669 chr1:150777565 T/C cg15448220 chr1:150897856 SETDB1 0.53 7.39 0.38 1.22e-12 Melanoma; CRC cis rs6499188 1.000 rs6499188 chr16:68674788 G/A cg02972257 chr16:68554789 NA -0.48 -6.41 -0.33 4.97e-10 Ulcerative colitis; CRC cis rs826838 0.586 rs10880753 chr12:38628147 C/A cg13010199 chr12:38710504 ALG10B -0.42 -6.03 -0.32 4.3e-9 Heart rate; CRC cis rs7107174 1.000 rs7111986 chr11:78102266 G/T cg02023728 chr11:77925099 USP35 0.47 7.2 0.37 4.24e-12 Testicular germ cell tumor; CRC cis rs10504229 1.000 rs17816781 chr8:58186161 A/T cg24829409 chr8:58192753 C8orf71 -0.68 -11.34 -0.53 2.27e-25 Developmental language disorder (linguistic errors); CRC cis rs9311474 0.607 rs11711421 chr3:52561779 C/T cg18099408 chr3:52552593 STAB1 -0.48 -8.5 -0.42 6.6e-16 Electroencephalogram traits; CRC cis rs992157 0.835 rs2271543 chr2:219142491 C/T cg04731861 chr2:219085781 ARPC2 0.33 6.94 0.36 2.06e-11 Colorectal cancer; CRC cis rs9341808 0.667 rs2505944 chr6:80888410 T/C cg08355045 chr6:80787529 NA 0.35 6.01 0.31 4.88e-9 Sitting height ratio; CRC cis rs4363385 0.818 rs3795381 chr1:153004848 T/C cg25856811 chr1:152973957 SPRR3 -0.25 -6.93 -0.36 2.19e-11 Inflammatory skin disease; CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg18342900 chr16:46865048 C16orf87 -0.56 -7.12 -0.37 6.67e-12 Diisocyanate-induced asthma; CRC cis rs6662572 1.000 rs55951835 chr1:46132442 T/C cg03123370 chr1:45965343 CCDC163P;MMACHC 0.49 5.86 0.31 1.12e-8 Blood protein levels; CRC cis rs8180040 0.800 rs11920354 chr3:47262246 C/A cg27129171 chr3:47204927 SETD2 -0.68 -10.51 -0.5 1.87e-22 Colorectal cancer; CRC cis rs9828933 0.752 rs28675788 chr3:63942188 C/G cg16258503 chr3:63850278 ATXN7;THOC7 -0.81 -8.32 -0.42 2.31e-15 Type 2 diabetes; CRC cis rs653465 0.583 rs7652855 chr3:27257026 G/A cg02860705 chr3:27208620 NA 0.4 6.17 0.32 2.05e-9 Breast cancer (early onset); CRC cis rs9486715 0.825 rs211158 chr6:97022938 C/G cg06623918 chr6:96969491 KIAA0776 -0.97 -17.69 -0.7 1.11e-49 Headache; CRC cis rs10789491 1.000 rs35861275 chr1:47171909 A/C cg15501359 chr1:47185051 KIAA0494 -0.72 -8.14 -0.41 8.43e-15 Response to hepatitis C treatment; CRC cis rs748404 0.660 rs2439845 chr15:43722610 C/G cg15269541 chr15:43626905 ADAL -0.36 -5.64 -0.3 3.7e-8 Lung cancer; CRC cis rs10540 0.908 rs1044707 chr11:491334 G/T cg21784768 chr11:537496 LRRC56 0.65 6.32 0.33 8.36e-10 Body mass index; CRC cis rs12762955 0.561 rs4880744 chr10:1012026 A/G cg19847866 chr10:1019161 NA 0.43 6.4 0.33 5.29e-10 Response to angiotensin II receptor blocker therapy; CRC cis rs185694 1.000 rs613291 chr13:30894404 T/C cg07600127 chr13:30881527 KATNAL1 -0.56 -5.87 -0.31 1.09e-8 Antineutrophil cytoplasmic antibody-associated vasculitis; CRC cis rs796364 0.806 rs1605900 chr2:200870197 C/G cg25936922 chr2:200820526 C2orf60;C2orf47 0.68 6.64 0.34 1.33e-10 Schizophrenia; CRC cis rs9463078 0.605 rs17422760 chr6:44885288 C/T cg25276700 chr6:44698697 NA 0.23 5.66 0.3 3.37e-8 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; CRC cis rs897984 0.762 rs12931046 chr16:30987144 G/A cg02466173 chr16:30829666 NA 0.61 9.0 0.44 1.87e-17 Dementia with Lewy bodies; CRC cis rs62458065 0.850 rs62458098 chr7:32471129 G/A cg20159608 chr7:32802032 NA -0.55 -6.56 -0.34 2.11e-10 Metabolite levels (HVA/MHPG ratio); CRC cis rs34787248 1 rs34787248 chr6:28197886 C/T cg15786705 chr6:28176104 NA 0.68 7.39 0.38 1.23e-12 Autism spectrum disorder or schizophrenia; CRC cis rs2625529 0.652 rs2930069 chr15:72226977 G/A cg16672083 chr15:72433130 SENP8 0.46 6.96 0.36 1.9e-11 Red blood cell count; CRC cis rs9549367 0.713 rs9549691 chr13:113861606 A/C cg18105134 chr13:113819100 PROZ -0.79 -12.18 -0.56 2.06e-28 Platelet distribution width; CRC cis rs9443645 0.901 rs9343843 chr6:79585625 C/T cg09184832 chr6:79620586 NA -0.52 -9.73 -0.47 8.04e-20 Intelligence (multi-trait analysis); CRC cis rs4743820 0.651 rs4744036 chr9:93932466 G/A cg14446406 chr9:93919335 NA -0.69 -12.14 -0.56 2.75e-28 Ulcerative colitis;Inflammatory bowel disease; CRC cis rs6502050 0.799 rs8066370 chr17:80102105 T/C cg22110888 chr17:80059540 CCDC57 0.4 6.44 0.33 4.17e-10 Life satisfaction; CRC cis rs478304 0.593 rs12576766 chr11:65488556 C/T cg27068330 chr11:65405492 SIPA1 -0.67 -9.87 -0.48 2.75e-20 Acne (severe); CRC cis rs514406 0.505 rs427319 chr1:53178807 T/G cg25767906 chr1:53392781 SCP2 -0.39 -6.11 -0.32 2.86e-9 Monocyte count; CRC cis rs875971 0.862 rs6962717 chr7:65883735 G/A cg18252515 chr7:66147081 NA -0.41 -5.94 -0.31 7.15e-9 Aortic root size; CRC cis rs7119 0.717 rs8033067 chr15:77825495 G/T cg10437265 chr15:77819839 NA 0.69 12.51 0.57 1.24e-29 Type 2 diabetes; CRC trans rs1656966 1.000 rs1656966 chr3:186466252 C/T cg05792022 chr13:41239732 FOXO1 0.41 6.01 0.31 4.86e-9 Myopia (pathological); CRC cis rs11764590 0.585 rs11772463 chr7:2078132 A/C cg02421172 chr7:1938701 MAD1L1 0.47 6.21 0.32 1.6e-9 Neuroticism; CRC cis rs1799949 1.000 rs67060599 chr17:41255102 A/G cg01879757 chr17:41196368 BRCA1 -0.41 -6.05 -0.32 3.86e-9 Menopause (age at onset); CRC cis rs57221529 0.766 rs12518859 chr5:587432 C/T cg16447950 chr5:562315 NA -0.83 -10.78 -0.51 2.14e-23 Lung disease severity in cystic fibrosis; CRC cis rs651907 0.557 rs35117343 chr3:101445126 A/G cg11279151 chr3:101281821 RG9MTD1 -0.54 -7.4 -0.38 1.12e-12 Colorectal cancer; CRC cis rs11122272 0.735 rs2437147 chr1:231516756 T/C cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.54 -8.09 -0.41 1.18e-14 Hemoglobin concentration; CRC cis rs9287719 0.601 rs12996735 chr2:10716716 C/A cg00105475 chr2:10696890 NA 0.49 7.38 0.38 1.33e-12 Prostate cancer; CRC cis rs3858526 0.874 rs10838879 chr11:5950169 C/T cg13902645 chr11:5959945 NA -0.64 -9.0 -0.44 1.81e-17 DNA methylation (variation); CRC cis rs2032447 0.672 rs9379811 chr6:25955197 G/C cg18357526 chr6:26021779 HIST1H4A 0.67 10.02 0.48 8.74e-21 Intelligence (multi-trait analysis); CRC cis rs3820068 0.581 rs72645881 chr1:15928203 C/T cg13390004 chr1:15929781 NA 0.51 7.2 0.37 4.22e-12 Systolic blood pressure; CRC cis rs801193 1.000 rs10234018 chr7:66146284 A/T cg00343986 chr7:65444356 GUSB -0.48 -7.25 -0.37 2.98e-12 Aortic root size; CRC cis rs6502050 0.805 rs62080003 chr17:80078957 C/T cg13198984 chr17:80129470 CCDC57 -0.46 -7.99 -0.4 2.25e-14 Life satisfaction; CRC trans rs1005277 0.579 rs1740732 chr10:38491385 C/T cg11292332 chr7:45801988 SEPT13 -0.39 -7.1 -0.36 7.55e-12 Extrinsic epigenetic age acceleration; CRC cis rs10883723 0.810 rs7090276 chr10:104281239 G/T cg04362960 chr10:104952993 NT5C2 -0.42 -5.9 -0.31 8.92e-9 Allergic disease (asthma, hay fever or eczema); CRC cis rs73206853 0.688 rs7314248 chr12:110559173 G/A cg12870014 chr12:110450643 ANKRD13A 0.82 9.4 0.46 9.47e-19 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC cis rs861020 0.630 rs655712 chr1:210006437 G/A cg05527609 chr1:210001259 C1orf107 0.77 10.66 0.51 5.37e-23 Orofacial clefts; CRC cis rs561341 0.709 rs11542477 chr17:30185892 A/G cg19193384 chr17:30244184 NA 0.52 6.0 0.31 5.13e-9 Hip circumference adjusted for BMI; CRC cis rs13108904 0.934 rs4974596 chr4:1301052 A/G cg02018176 chr4:1364513 KIAA1530 0.46 7.43 0.38 9.36e-13 Obesity-related traits; CRC cis rs11971779 0.680 rs7779900 chr7:139082987 G/T cg07862535 chr7:139043722 LUC7L2 0.57 7.35 0.38 1.61e-12 Diisocyanate-induced asthma; CRC cis rs2066819 1.000 rs2371454 chr12:56647243 A/G cg26714650 chr12:56694279 CS 1.36 11.13 0.52 1.22e-24 Psoriasis vulgaris; CRC trans rs7148069 0.553 rs17123829 chr14:51824498 G/A cg24818418 chr4:110834590 EGF 0.44 6.03 0.32 4.47e-9 Nonsyndromic cleft lip with cleft palate; CRC cis rs6912958 0.728 rs7773906 chr6:88251869 T/A cg12350822 chr6:88032061 C6orf162;GJB7 -0.33 -6.36 -0.33 6.84e-10 Monocyte percentage of white cells; CRC cis rs4713118 0.513 rs149989 chr6:27998184 T/A cg10876282 chr6:28092338 ZSCAN16 0.46 6.37 0.33 6.25e-10 Parkinson's disease; CRC cis rs1448094 0.791 rs10863124 chr12:86352548 A/T cg18827107 chr12:86230957 RASSF9 -0.41 -6.57 -0.34 2.03e-10 Major depressive disorder; CRC trans rs1005277 0.579 rs2474568 chr10:38383147 A/T cg17830980 chr10:43048298 ZNF37B -0.59 -9.84 -0.48 3.27e-20 Extrinsic epigenetic age acceleration; CRC cis rs9467773 0.869 rs1796521 chr6:26421392 T/C cg09904177 chr6:26538194 HMGN4 -0.66 -9.8 -0.48 4.77e-20 Intelligence (multi-trait analysis); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg22303846 chr2:152145870 NMI 0.42 6.31 0.33 8.76e-10 Intelligence (multi-trait analysis); CRC cis rs12451471 0.559 rs12452263 chr17:78079310 T/C cg20811857 chr17:78079795 GAA -0.46 -6.77 -0.35 6.01e-11 Plateletcrit;Mean corpuscular hemoglobin concentration; CRC cis rs3733585 0.699 rs6449202 chr4:9974043 T/C cg11266682 chr4:10021025 SLC2A9 -0.46 -9.51 -0.46 4.33e-19 Cleft plate (environmental tobacco smoke interaction); CRC cis rs2228479 0.702 rs12600047 chr16:89831630 G/A cg06558623 chr16:89946397 TCF25 1.11 9.98 0.48 1.13e-20 Skin colour saturation; CRC trans rs6951245 0.748 rs79658522 chr7:1095877 A/G cg13565492 chr6:43139072 SRF -0.71 -7.38 -0.38 1.32e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs55702914 0.742 rs6744206 chr2:198148522 A/G cg10820045 chr2:198174542 NA -0.44 -7.97 -0.4 2.6e-14 Major depression and alcohol dependence; CRC cis rs9368481 0.569 rs10946868 chr6:26887930 A/G cg12292205 chr6:26970375 C6orf41 0.63 9.89 0.48 2.26e-20 Autism spectrum disorder or schizophrenia; CRC cis rs9527 0.545 rs12247514 chr10:104958066 C/A cg04362960 chr10:104952993 NT5C2 0.61 8.56 0.43 4.54e-16 Arsenic metabolism; CRC cis rs12630931 1.000 rs73061493 chr3:31984329 T/A cg21375017 chr3:31988082 OSBPL10 0.43 5.89 0.31 9.55e-9 Periodontal disease-related phenotypes; CRC cis rs7605827 0.930 rs918157 chr2:15657729 G/A cg19274914 chr2:15703543 NA 0.39 5.9 0.31 9.11e-9 Educational attainment (years of education); CRC cis rs2576037 1.000 rs2576037 chr18:44585420 C/T cg07416455 chr18:44543612 TCEB3CL;KATNAL2 0.51 7.49 0.38 6.56e-13 Personality dimensions; CRC cis rs2302190 0.882 rs1974586 chr17:56640731 C/T cg25885038 chr17:56607967 SEPT4 -0.51 -7.72 -0.39 1.44e-13 Vitamin D levels; CRC cis rs7937682 0.889 rs541198 chr11:111475340 A/G cg19812747 chr11:111475976 SIK2 -0.59 -10.14 -0.49 3.31e-21 Primary sclerosing cholangitis; CRC cis rs2153535 0.580 rs2225765 chr6:8481785 A/G cg21535247 chr6:8435926 SLC35B3 0.49 7.38 0.38 1.3e-12 Motion sickness; CRC cis rs116095464 0.867 rs10074958 chr5:230828 C/T cg22857025 chr5:266934 NA -1.21 -16.46 -0.67 7.6e-45 Breast cancer; CRC cis rs4478858 0.684 rs16834336 chr1:31751512 G/A cg00250761 chr1:31883323 NA -0.44 -8.59 -0.43 3.52e-16 Alcohol dependence; CRC trans rs13046373 0.905 rs4816372 chr21:32077414 A/T cg05553502 chr5:92924091 NR2F1 -0.27 -6.01 -0.31 4.84e-9 HDL cholesterol; CRC cis rs3087591 0.708 rs7505 chr17:29644852 G/A cg24425628 chr17:29625626 OMG;NF1 0.71 13.05 0.58 1.15e-31 Hip circumference; CRC cis rs10131894 0.611 rs175002 chr14:75436466 C/G cg08847533 chr14:75593920 NEK9 0.66 10.68 0.51 4.65e-23 Coronary artery disease; CRC cis rs10751667 1.000 rs10751667 chr11:941941 A/T ch.11.42038R chr11:967971 AP2A2 0.64 10.27 0.49 1.21e-21 Alzheimer's disease (late onset); CRC cis rs1862618 0.525 rs832403 chr5:56265992 G/T cg03609598 chr5:56110824 MAP3K1 0.66 7.51 0.38 5.62e-13 Initial pursuit acceleration; CRC cis rs853679 0.825 rs8180562 chr6:28141460 G/A cg15845792 chr6:28175446 NA 0.8 6.4 0.33 5.31e-10 Depression; CRC cis rs1046896 0.594 rs4075209 chr17:80800027 G/T cg03160526 chr17:80928410 B3GNTL1 0.58 7.66 0.39 2.05e-13 Glycated hemoglobin levels; CRC cis rs11190604 1.000 rs7099965 chr10:102301165 A/G cg16342193 chr10:102329863 NA -0.36 -5.95 -0.31 6.71e-9 Palmitoleic acid (16:1n-7) levels; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg27665925 chr19:12098906 NA 0.39 6.1 0.32 3e-9 Liver disease severity in Alagille syndrome; CRC cis rs863345 0.604 rs1873510 chr1:158461418 G/A cg12129480 chr1:158549410 OR10X1 -0.29 -6.04 -0.32 4.2e-9 Pneumococcal bacteremia; CRC trans rs8002861 0.870 rs4942255 chr13:44451844 A/T cg17145862 chr1:211918768 LPGAT1 -0.71 -14.06 -0.61 1.66e-35 Leprosy; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg17848531 chr2:182756352 SSFA2 0.53 7.98 0.4 2.41e-14 Intelligence (multi-trait analysis); CRC cis rs7772486 0.590 rs1890170 chr6:146071839 G/C cg05347473 chr6:146136440 FBXO30 -0.49 -7.06 -0.36 1e-11 Lobe attachment (rater-scored or self-reported); CRC cis rs7927592 0.956 rs11228278 chr11:68308530 G/A cg16797656 chr11:68205561 LRP5 0.4 6.7 0.35 9.18e-11 Total body bone mineral density; CRC cis rs2281845 0.507 rs10800760 chr1:201100439 G/A cg08885800 chr1:201084119 NA 0.41 5.7 0.3 2.62e-8 Permanent tooth development; CRC trans rs561341 1.000 rs55962687 chr17:30260369 C/T cg27661571 chr11:113659931 NA -0.95 -10.95 -0.52 5.51e-24 Hip circumference adjusted for BMI; CRC cis rs17092148 0.836 rs4564863 chr20:33179367 T/C cg08999081 chr20:33150536 PIGU 0.49 6.3 0.33 9.31e-10 Neuroticism; CRC cis rs853679 0.628 rs9368560 chr6:28159960 T/C cg03623178 chr6:28175578 NA 0.95 13.37 0.59 7.53e-33 Depression; CRC cis rs7591163 1.000 rs6436741 chr2:228714598 G/A cg23807890 chr2:228736357 WDR69 -0.51 -6.99 -0.36 1.56e-11 Blood pressure; CRC trans rs1997103 1.000 rs10249105 chr7:55412405 A/G cg20935933 chr6:143382018 AIG1 -0.47 -6.22 -0.32 1.5e-9 QRS interval (sulfonylurea treatment interaction); CRC cis rs7149337 0.805 rs3007164 chr14:51646935 A/G cg23942311 chr14:51606299 NA 0.76 14.37 0.62 1.12e-36 Cancer; CRC cis rs3126085 0.935 rs10888473 chr1:152220235 G/A cg09127314 chr1:152161683 NA 0.47 6.02 0.31 4.67e-9 Atopic dermatitis; CRC cis rs2976388 0.609 rs2717603 chr8:143803193 T/C cg05569086 chr8:143859399 LYNX1 0.38 6.59 0.34 1.79e-10 Urinary tract infection frequency; CRC cis rs863345 0.565 rs7549123 chr1:158444920 A/T cg12129480 chr1:158549410 OR10X1 -0.29 -6.08 -0.32 3.27e-9 Pneumococcal bacteremia; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg16139199 chr18:19180362 ESCO1 0.51 6.83 0.35 4.22e-11 Thyroid stimulating hormone; CRC cis rs4713118 0.869 rs6930992 chr6:27712120 A/C cg19041857 chr6:27730383 NA -0.41 -6.0 -0.31 5.3300000000000004e-09 Parkinson's disease; CRC trans rs1005277 0.579 rs1740745 chr10:38520056 T/C cg17830980 chr10:43048298 ZNF37B -0.57 -9.68 -0.47 1.16e-19 Extrinsic epigenetic age acceleration; CRC cis rs875971 0.862 rs13226170 chr7:65999298 G/A cg18252515 chr7:66147081 NA -0.43 -6.21 -0.32 1.56e-9 Aortic root size; CRC cis rs9308731 0.644 rs60286362 chr2:111877493 G/C cg04202892 chr2:111875749 ACOXL 0.47 7.76 0.39 1.06e-13 Chronic lymphocytic leukemia; CRC cis rs17270561 0.609 rs9358879 chr6:25742918 C/G cg16482183 chr6:26056742 HIST1H1C 0.83 10.69 0.51 4.46e-23 Iron status biomarkers; CRC trans rs2228479 0.702 rs11646374 chr16:89857935 G/A cg24644049 chr4:85504048 CDS1 0.83 7.0 0.36 1.47e-11 Skin colour saturation; CRC cis rs10479542 0.752 rs12658664 chr5:178986987 C/T cg05457628 chr5:178986728 RUFY1 0.42 6.86 0.35 3.33e-11 Lung cancer; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg12450255 chr15:34659304 LPCAT4 0.48 6.9 0.36 2.66e-11 Response to antipsychotic treatment; CRC cis rs11122272 0.735 rs2256908 chr1:231506557 G/A cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.54 -8.07 -0.41 1.33e-14 Hemoglobin concentration; CRC cis rs6456156 0.742 rs3093026 chr6:167532690 A/G cg19688584 chr6:167529678 CCR6 0.33 6.04 0.32 4.06e-9 Primary biliary cholangitis; CRC cis rs853679 0.517 rs3173443 chr6:28137027 T/G cg02631126 chr6:28058918 ZSCAN12L1 0.29 5.91 0.31 8.38e-9 Depression; CRC cis rs6496667 0.779 rs7175440 chr15:90949403 C/T cg04176472 chr15:90893244 GABARAPL3 0.6 7.77 0.39 1.02e-13 Rheumatoid arthritis; CRC cis rs6502050 0.835 rs6502068 chr17:80112223 C/T cg22110888 chr17:80059540 CCDC57 0.4 6.31 0.33 8.87e-10 Life satisfaction; CRC cis rs898097 0.801 rs68141193 chr17:80878816 C/T cg03160526 chr17:80928410 B3GNTL1 -0.4 -5.64 -0.3 3.7e-8 Breast cancer; CRC cis rs2204008 0.774 rs11615665 chr12:38328162 T/A cg26384229 chr12:38710491 ALG10B 0.67 9.37 0.46 1.19e-18 Bladder cancer; CRC cis rs9611565 0.918 rs6002351 chr22:41757223 C/T cg06634786 chr22:41940651 POLR3H -0.44 -6.02 -0.32 4.55e-9 Vitiligo; CRC cis rs11123610 0.520 rs7576146 chr2:3718393 A/C cg00999904 chr2:3704751 ALLC -0.53 -6.7 -0.35 9.16e-11 Response to inhaled corticosteroid treatment in asthma (change in FEV1); CRC trans rs4714291 0.832 rs9471247 chr6:40105318 A/G cg02267698 chr19:7991119 CTXN1 -0.52 -6.96 -0.36 1.8e-11 Strep throat; CRC cis rs9650315 0.706 rs36112366 chr8:57138676 T/G cg23139584 chr8:56987506 RPS20;SNORD54 0.55 5.98 0.31 5.77e-9 Height; CRC cis rs11764590 0.950 rs55683212 chr7:2078855 G/C cg23422044 chr7:1970798 MAD1L1 -0.53 -6.5 -0.34 3.06e-10 Neuroticism; CRC cis rs13191362 1.000 rs13191362 chr6:163033350 A/G cg14584255 chr6:163149320 PACRG;PARK2 0.4 5.84 0.31 1.24e-8 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs9399135 0.967 rs9402676 chr6:135355507 C/T cg24558204 chr6:135376177 HBS1L 0.51 8.07 0.41 1.34e-14 Red blood cell count; CRC cis rs7428 0.545 rs2366404 chr2:85551779 G/A cg24342717 chr2:85555507 TGOLN2 -0.72 -11.87 -0.55 2.66e-27 Ear protrusion; CRC cis rs3768617 1.000 rs3820697 chr1:183100226 T/C ch.1.3577855R chr1:183094577 LAMC1 0.62 9.28 0.46 2.31e-18 Fuchs's corneal dystrophy; CRC cis rs10971721 0.908 rs55684780 chr9:33833208 A/G cg13495928 chr9:33750294 PRSS3 0.55 5.93 0.31 7.7e-9 Body mass index; CRC cis rs311392 0.902 rs413667 chr8:55091908 C/A cg06042504 chr8:55087323 NA -0.44 -6.86 -0.35 3.42e-11 Pelvic organ prolapse (moderate/severe); CRC cis rs10504229 0.683 rs16921819 chr8:58107936 G/T cg02290350 chr8:58132656 NA -0.59 -8.02 -0.4 1.88e-14 Developmental language disorder (linguistic errors); CRC cis rs11758351 0.660 rs16891443 chr6:26221937 A/C cg22723502 chr6:26240528 HIST1H4F -0.36 -5.85 -0.31 1.17e-8 Gout;Renal underexcretion gout; CRC cis rs7772486 0.790 rs2254283 chr6:146204289 T/C cg23711669 chr6:146136114 FBXO30 0.71 12.64 0.57 3.97e-30 Lobe attachment (rater-scored or self-reported); CRC trans rs561341 1.000 rs15654 chr17:30326360 A/C cg27661571 chr11:113659931 NA -0.95 -10.99 -0.52 3.76e-24 Hip circumference adjusted for BMI; CRC cis rs11608355 0.545 rs35422737 chr12:109911456 A/G cg05360138 chr12:110035743 NA 0.78 8.76 0.43 1.07e-16 Neuroticism; CRC cis rs672059 1.000 rs510642 chr1:183162776 A/C ch.1.3577855R chr1:183094577 LAMC1 0.48 6.88 0.35 3.1e-11 Hypertriglyceridemia; CRC cis rs875971 0.651 rs2420596 chr7:65915983 T/C cg12463550 chr7:65579703 CRCP 0.49 6.8 0.35 4.87e-11 Aortic root size; CRC cis rs5769765 0.908 rs9616376 chr22:50310829 A/G cg22709217 chr22:50311962 ALG12;CRELD2 -1.11 -18.12 -0.71 2.17e-51 Schizophrenia; CRC cis rs1008375 1.000 rs10805358 chr4:17652450 A/C cg02297831 chr4:17616191 MED28 0.45 5.98 0.31 5.67e-9 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs9992667 0.955 rs11096953 chr4:38643792 A/G cg19726192 chr4:38663646 FLJ13197 0.66 8.66 0.43 2.21e-16 Eosinophil percentage of granulocytes; CRC cis rs72717009 0.825 rs867624 chr1:161467837 A/T cg23840854 chr1:161414152 NA -0.67 -7.84 -0.4 6.19e-14 Rheumatoid arthritis; CRC cis rs1218582 0.741 rs10908447 chr1:154869742 C/T cg06221963 chr1:154839813 KCNN3 -0.81 -15.39 -0.65 1.28e-40 Prostate cancer; CRC cis rs1862618 0.853 rs252887 chr5:56166188 A/G cg03609598 chr5:56110824 MAP3K1 -0.84 -9.89 -0.48 2.37e-20 Initial pursuit acceleration; CRC cis rs7177699 0.557 rs6495335 chr15:79117133 G/T cg15571903 chr15:79123663 NA 0.31 6.21 0.32 1.61e-9 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; CRC cis rs11031096 0.542 rs7924984 chr11:3974588 C/T cg18678763 chr11:4115507 RRM1 -0.41 -6.84 -0.35 3.91e-11 Mean corpuscular volume;Mean corpuscular hemoglobin; CRC cis rs3733585 0.699 rs12498150 chr4:9950537 C/T cg11266682 chr4:10021025 SLC2A9 -0.47 -9.49 -0.46 4.9e-19 Cleft plate (environmental tobacco smoke interaction); CRC cis rs12701220 0.655 rs34696066 chr7:1140919 C/T cg02733842 chr7:1102375 C7orf50 -0.61 -7.43 -0.38 9.74e-13 Bronchopulmonary dysplasia; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg08965527 chr16:84178213 HSDL1;LRRC50 0.4 5.98 0.31 5.8e-9 Liver disease severity in Alagille syndrome; CRC cis rs17270561 0.636 rs7775354 chr6:25745266 T/A cg17691542 chr6:26056736 HIST1H1C 0.72 9.24 0.45 3.07e-18 Iron status biomarkers; CRC cis rs13191362 1.000 rs34443622 chr6:163208214 T/C cg06582575 chr6:163149167 PACRG;PARK2 0.91 11.49 0.54 6.54e-26 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs7119 0.717 rs12910975 chr15:77817487 C/T cg10437265 chr15:77819839 NA 0.69 12.74 0.57 1.76e-30 Type 2 diabetes; CRC cis rs1448094 0.511 rs10863080 chr12:86153149 C/T cg25456477 chr12:86230367 RASSF9 -0.39 -6.54 -0.34 2.36e-10 Major depressive disorder; CRC cis rs4665809 0.531 rs34081866 chr2:26475940 C/T cg04944784 chr2:26401820 FAM59B 0.86 11.56 0.54 3.73e-26 Gut microbiome composition (summer); CRC cis rs8072100 0.701 rs8075566 chr17:45771037 G/A cg08085267 chr17:45401833 C17orf57 -0.45 -6.59 -0.34 1.72e-10 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC trans rs7615952 0.599 rs1044215 chr3:125725559 C/G cg07211511 chr3:129823064 LOC729375 -0.79 -12.51 -0.57 1.27e-29 Blood pressure (smoking interaction); CRC cis rs6088580 0.634 rs6059851 chr20:33047945 G/A cg24642439 chr20:33292090 TP53INP2 0.37 6.23 0.32 1.43e-9 Glomerular filtration rate (creatinine); CRC cis rs12476592 0.714 rs262494 chr2:63845484 C/T cg10828910 chr2:63850056 LOC388955 0.53 6.58 0.34 1.83e-10 Childhood ear infection; CRC cis rs1712517 0.566 rs7076274 chr10:105046007 G/A cg04362960 chr10:104952993 NT5C2 -0.47 -6.15 -0.32 2.29e-9 Migraine; CRC cis rs10782582 0.609 rs1770882 chr1:76411549 G/A cg03433033 chr1:76189801 ACADM -0.4 -5.82 -0.31 1.37e-8 Daytime sleep phenotypes; CRC cis rs9311474 0.607 rs11711421 chr3:52561779 C/T cg15147215 chr3:52552868 STAB1 -0.63 -11.12 -0.52 1.3e-24 Electroencephalogram traits; CRC cis rs10504229 0.954 rs114134184 chr8:58181969 G/A cg02290350 chr8:58132656 NA -0.42 -5.96 -0.31 6.62e-9 Developmental language disorder (linguistic errors); CRC cis rs9322193 0.886 rs9322198 chr6:149944908 T/C cg00933542 chr6:150070202 PCMT1 0.29 6.08 0.32 3.37e-9 Lung cancer; CRC trans rs3780486 0.846 rs10758192 chr9:33131651 G/A cg20290983 chr6:43655470 MRPS18A 1.16 27.12 0.83 6.77e-86 IgG glycosylation; CRC cis rs2249694 0.520 rs6537609 chr10:135323084 A/G cg20169779 chr10:135381914 SYCE1 -0.53 -7.24 -0.37 3.18e-12 Obesity-related traits; CRC cis rs6545883 0.931 rs7557230 chr2:61736652 A/T cg15711740 chr2:61764176 XPO1 -0.52 -7.19 -0.37 4.39e-12 Tuberculosis; CRC cis rs4481887 0.927 rs4409694 chr1:248485498 C/T cg00666640 chr1:248458726 OR2T12 0.47 8.15 0.41 7.73e-15 Common traits (Other); CRC cis rs1387259 0.790 rs2732445 chr12:48645533 C/T cg21466736 chr12:48725269 NA -0.55 -8.1 -0.41 1.11e-14 Obstructive sleep apnea trait (apnea hypopnea index); CRC cis rs12188164 0.930 rs72717436 chr5:448291 C/A cg21972741 chr5:435613 AHRR 0.54 7.37 0.38 1.39e-12 Cystic fibrosis severity; CRC cis rs739401 0.619 rs10766482 chr11:2961600 C/T cg25174290 chr11:3078921 CARS 0.39 5.74 0.3 2.12e-8 Longevity; CRC cis rs7552404 0.628 rs5745442 chr1:76342858 T/G cg03433033 chr1:76189801 ACADM 0.72 8.62 0.43 2.8e-16 Blood metabolite levels;Acylcarnitine levels; CRC cis rs7072216 0.763 rs7909822 chr10:100172035 A/C cg26618903 chr10:100175079 PYROXD2 -0.52 -8.48 -0.42 7.76e-16 Metabolite levels; CRC trans rs2303319 0.504 rs62187609 chr2:162431500 C/T cg18122310 chr12:50236657 BCDIN3D -0.75 -6.2 -0.32 1.68e-9 Cognitive function; CRC cis rs11077998 0.967 rs11657886 chr17:80516173 T/C cg10255544 chr17:80519551 FOXK2 0.37 5.82 0.31 1.39e-8 Reticulocyte fraction of red cells; CRC cis rs1707322 0.964 rs785508 chr1:46527159 G/A cg06784218 chr1:46089804 CCDC17 -0.55 -9.46 -0.46 6.32e-19 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs7945718 0.934 rs10831905 chr11:12776467 C/T cg25843174 chr11:12811716 TEAD1 -0.5 -9.45 -0.46 6.36e-19 Educational attainment (years of education); CRC cis rs11690935 0.959 rs1474074 chr2:172659852 G/A cg13550731 chr2:172543902 DYNC1I2 -1.06 -17.08 -0.69 2.77e-47 Schizophrenia; CRC cis rs1008375 0.898 rs7670500 chr4:17586957 A/G cg02297831 chr4:17616191 MED28 0.45 5.82 0.31 1.41e-8 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs35146811 0.806 rs1534310 chr7:99699169 A/T cg13334819 chr7:99746414 C7orf59 -0.57 -7.7 -0.39 1.58e-13 Coronary artery disease; CRC cis rs9837602 0.872 rs4928234 chr3:99704861 T/C cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G -0.48 -5.74 -0.3 2.13e-8 Breast cancer; CRC cis rs910316 0.763 rs175057 chr14:75489632 C/T cg03030879 chr14:75389066 RPS6KL1 0.4 6.06 0.32 3.66e-9 Height; CRC trans rs4942242 0.626 rs7986998 chr13:44209916 G/A cg26741380 chr15:41871084 TYRO3 0.45 6.2 0.32 1.73e-9 Response to tocilizumab in rheumatoid arthritis; CRC cis rs7618915 0.531 rs77146033 chr3:52701501 G/T cg11645453 chr3:52864694 ITIH4 0.36 6.18 0.32 1.91e-9 Bipolar disorder; CRC cis rs6840360 0.667 rs2709829 chr4:152355390 C/T cg09659197 chr4:152720779 NA 0.34 6.66 0.34 1.14e-10 Intelligence (multi-trait analysis); CRC trans rs208520 0.874 rs208485 chr6:66925654 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.91 -11.82 -0.55 3.98e-27 Exhaled nitric oxide output; CRC cis rs2952156 0.920 rs907090 chr17:37833632 T/C cg00129232 chr17:37814104 STARD3 -0.68 -12.01 -0.55 8.36e-28 Asthma; CRC cis rs2073300 0.609 rs6137951 chr20:23429459 T/C cg12062639 chr20:23401060 NAPB 0.81 7.08 0.36 8.92e-12 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs12762955 0.561 rs1904671 chr10:1014603 G/A cg20503657 chr10:835505 NA -0.44 -6.08 -0.32 3.24e-9 Response to angiotensin II receptor blocker therapy; CRC cis rs933688 1.000 rs6867219 chr5:90718008 T/G cg26981201 chr5:90679533 LOC100129716;ARRDC3 1.02 15.59 0.65 1.97e-41 Smoking behavior; CRC cis rs11123170 0.650 rs2289897 chr2:113977454 G/A cg01577475 chr2:114033581 PAX8;LOC440839 -0.27 -5.68 -0.3 3.04e-8 Renal function-related traits (BUN); CRC cis rs9807989 0.839 rs10204837 chr2:102977730 C/A cg03938978 chr2:103052716 IL18RAP 0.37 6.1 0.32 3.01e-9 Asthma; CRC cis rs1552244 0.935 rs7649243 chr3:10089470 T/A cg00166722 chr3:10149974 C3orf24 0.7 9.53 0.46 3.69e-19 Alzheimer's disease; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg04847795 chr1:70820736 HHLA3;ANKRD13C 0.4 6.44 0.33 4.22e-10 Liver disease severity in Alagille syndrome; CRC cis rs6964587 0.626 rs68009402 chr7:91516226 G/A cg17063962 chr7:91808500 NA -0.58 -9.22 -0.45 3.52e-18 Breast cancer; CRC cis rs9372498 0.764 rs4599686 chr6:118722118 T/A cg18833306 chr6:118973337 C6orf204 0.49 6.19 0.32 1.83e-9 Diastolic blood pressure; CRC trans rs9341835 0.583 rs2753062 chr6:64131810 G/T cg13657004 chr13:50234944 EBPL -0.37 -6.29 -0.33 1.01e-9 Schizophrenia; CRC cis rs7811142 0.830 rs11761426 chr7:99956893 A/T cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.73 9.99 0.48 1.07e-20 Platelet count; CRC cis rs9649213 0.593 rs12672092 chr7:97986557 C/A cg00277769 chr7:97922759 BAIAP2L1 -0.6 -10.39 -0.5 4.76e-22 Prostate cancer (SNP x SNP interaction); CRC cis rs4713118 0.621 rs4713133 chr6:28034041 T/C cg25164649 chr6:28176230 NA 0.7 8.93 0.44 3.12e-17 Parkinson's disease; CRC trans rs10506458 0.915 rs17763441 chr12:63418335 T/C cg22491629 chr6:157744540 C6orf35 -0.71 -8.55 -0.43 4.75e-16 Hemostatic factors and hematological phenotypes; CRC cis rs116095464 0.558 rs73029475 chr5:206969 T/C cg22496380 chr5:211416 CCDC127 -0.95 -9.33 -0.46 1.66e-18 Breast cancer; CRC cis rs6460942 0.915 rs62448602 chr7:12457145 T/G cg20607287 chr7:12443886 VWDE -0.65 -6.92 -0.36 2.33e-11 Coronary artery disease; CRC cis rs12893668 0.703 rs729438 chr14:104092789 A/G cg24130564 chr14:104152367 KLC1 0.44 6.0 0.31 5.28e-9 Reticulocyte count; CRC cis rs11785400 1.000 rs13266249 chr8:143732433 A/C cg24634471 chr8:143751801 JRK 0.56 7.9 0.4 4.08e-14 Schizophrenia; CRC cis rs477895 0.713 rs2282490 chr11:63962152 T/C cg04317338 chr11:64019027 PLCB3 0.6 7.36 0.38 1.45e-12 Mean platelet volume; CRC cis rs8072100 0.713 rs9895776 chr17:45486003 A/G cg25173405 chr17:45401733 C17orf57 -0.43 -6.5 -0.34 2.93e-10 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs2991971 0.967 rs512026 chr1:46009946 G/T cg15605315 chr1:45957053 TESK2 0.42 6.76 0.35 6.28e-11 High light scatter reticulocyte count; CRC cis rs9914988 0.887 rs11652710 chr17:27145075 C/T cg07195577 chr17:27052828 TLCD1 0.41 5.92 0.31 7.89e-9 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs2180341 0.920 rs6916990 chr6:127698759 G/A cg27446573 chr6:127587934 RNF146 0.99 13.96 0.61 4.32e-35 Breast cancer; CRC cis rs7584330 0.697 rs9287620 chr2:238368730 C/T cg11271282 chr2:238384023 NA 0.48 6.14 0.32 2.39e-9 Prostate cancer; CRC cis rs7618915 0.501 rs7624716 chr3:52751534 T/C cg18404041 chr3:52824283 ITIH1 -0.4 -8.28 -0.42 3.21e-15 Bipolar disorder; CRC cis rs10504229 0.683 rs882429 chr8:58129292 A/G cg22535103 chr8:58192502 C8orf71 -0.7 -9.34 -0.46 1.47e-18 Developmental language disorder (linguistic errors); CRC cis rs1799949 1.000 rs8176077 chr17:41276348 T/C cg23758822 chr17:41437982 NA 0.79 13.46 0.6 3.47e-33 Menopause (age at onset); CRC cis rs4332037 0.707 rs73046323 chr7:1882795 G/A cg25834613 chr7:1915315 MAD1L1 -0.41 -6.26 -0.33 1.24e-9 Bipolar disorder; CRC cis rs755249 0.567 rs76111861 chr1:39842690 G/T cg18385671 chr1:39797026 MACF1 -0.4 -5.78 -0.3 1.74e-8 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs9847710 0.818 rs6445558 chr3:53097660 G/T cg04503182 chr3:53078218 SFMBT1 -0.41 -6.4 -0.33 5.25e-10 Ulcerative colitis; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg09601704 chr17:8027427 HES7 0.39 6.64 0.34 1.28e-10 Liver disease severity in Alagille syndrome; CRC cis rs2396545 0.591 rs12802200 chr11:566936 C/A cg16486109 chr11:613632 IRF7 0.67 10.01 0.48 8.86e-21 Systemic lupus erythematosus and Systemic sclerosis; CRC cis rs2739330 0.760 rs1007888 chr22:24241101 C/T cg10150615 chr22:24372951 LOC391322 -0.56 -8.38 -0.42 1.56e-15 Liver enzyme levels (gamma-glutamyl transferase); CRC trans rs4263408 0.934 rs9683743 chr4:39703194 A/C cg18480310 chr19:39421315 MRPS12;SARS2 -0.41 -6.0 -0.31 5.2e-9 Plasma amyloid beta peptide concentrations (ABx-40); CRC cis rs13108904 0.521 rs4974609 chr4:1356924 A/C cg20092199 chr4:1342459 KIAA1530 -0.44 -8.08 -0.41 1.21e-14 Obesity-related traits; CRC trans rs2840044 0.963 rs225247 chr17:33944590 T/A cg19694781 chr19:47549865 TMEM160 -0.46 -7.31 -0.37 1.99e-12 Response to radiotherapy in cancer (late toxicity); CRC cis rs6977955 1.000 rs67250450 chr7:28174986 T/C cg23620719 chr7:28220237 JAZF1 0.42 5.62 0.3 4.13e-8 Allergic disease (asthma, hay fever or eczema); CRC cis rs3771570 1.000 rs3771570 chr2:242382864 C/T cg21155796 chr2:242212141 HDLBP 0.64 6.97 0.36 1.69e-11 Prostate cancer; CRC cis rs11098499 0.863 rs3775848 chr4:120447724 C/T cg09307838 chr4:120376055 NA 0.69 10.33 0.5 7.26e-22 Corneal astigmatism; CRC cis rs12791968 0.765 rs12226848 chr11:45009204 C/T cg11846598 chr11:44996168 LOC221122 -0.6 -8.72 -0.43 1.43e-16 Inhibitory control; CRC cis rs7772486 0.875 rs9322044 chr6:146369608 T/C cg23711669 chr6:146136114 FBXO30 0.68 11.75 0.54 7.23e-27 Lobe attachment (rater-scored or self-reported); CRC trans rs11343 0.675 rs7359333 chr16:19262344 A/T cg03637622 chr5:179334771 TBC1D9B -0.53 -6.82 -0.35 4.29e-11 Parkinson's disease; CRC cis rs9549367 0.713 rs3024744 chr13:113821477 A/C cg24300038 chr13:113819356 PROZ -0.47 -6.05 -0.32 3.88e-9 Platelet distribution width; CRC cis rs1552244 0.572 rs17032440 chr3:10169819 A/C cg00166722 chr3:10149974 C3orf24 -0.67 -7.97 -0.4 2.69e-14 Alzheimer's disease; CRC cis rs736408 0.812 rs6778329 chr3:52824610 G/A cg18404041 chr3:52824283 ITIH1 -0.53 -11.09 -0.52 1.74e-24 Bipolar disorder; CRC cis rs8180040 0.805 rs17410853 chr3:47363971 G/T cg10298567 chr3:47292165 KIF9 0.39 6.15 0.32 2.19e-9 Colorectal cancer; CRC cis rs473651 0.904 rs10929275 chr2:239323169 A/G cg21699342 chr2:239360505 ASB1 0.54 9.69 0.47 1.03e-19 Multiple system atrophy; CRC cis rs1524976 0.941 rs9854638 chr3:65477793 C/T cg16238336 chr3:65465873 MAGI1 -0.51 -7.07 -0.36 9.59e-12 PR interval; CRC cis rs7909074 1.000 rs10751360 chr10:45396971 G/A cg04218760 chr10:45406644 TMEM72 -0.35 -9.76 -0.47 6.33e-20 Mean corpuscular volume; CRC cis rs290268 1.000 rs290271 chr9:93551619 G/A cg02608019 chr9:93564028 SYK 0.46 7.31 0.37 1.98e-12 Platelet count; CRC cis rs11203032 0.831 rs11203024 chr10:90955239 G/T cg16672925 chr10:90967113 CH25H 0.45 5.74 0.3 2.17e-8 Heart failure; CRC cis rs6860806 0.507 rs635620 chr5:131720263 A/G cg20512303 chr5:131592959 PDLIM4 -0.4 -6.91 -0.36 2.5e-11 Breast cancer; CRC cis rs7568458 0.684 rs7579147 chr2:85805654 G/A cg02493740 chr2:85810744 VAMP5 -0.54 -8.2 -0.41 5.3e-15 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); CRC cis rs1129187 0.935 rs4987173 chr6:42931224 G/A cg10862848 chr6:42927986 GNMT -0.38 -8.87 -0.44 4.65e-17 Alzheimer's disease in APOE e4+ carriers; CRC cis rs6539288 0.677 rs2287163 chr12:107349294 C/T cg13491945 chr12:107078410 RFX4 0.34 5.77 0.3 1.79e-8 Total body bone mineral density; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg08642325 chr8:26149300 PPP2R2A 0.46 6.82 0.35 4.45e-11 Intelligence (multi-trait analysis); CRC cis rs9462846 0.841 rs66541797 chr6:42825942 C/T cg02353165 chr6:42928485 GNMT 0.52 6.68 0.35 9.95e-11 Blood protein levels; CRC cis rs8060686 0.641 rs3743735 chr16:68119555 G/A cg26727032 chr16:67993705 SLC12A4 -0.57 -6.59 -0.34 1.72e-10 HDL cholesterol;Metabolic syndrome; CRC cis rs6940638 0.531 rs12211984 chr6:26986054 G/C cg18867708 chr6:26865862 GUSBL1 0.38 5.82 0.31 1.39e-8 Intelligence (multi-trait analysis); CRC cis rs2404602 0.684 rs11072602 chr15:76873467 T/C cg23625390 chr15:77176239 SCAPER -0.91 -15.31 -0.65 2.44e-40 Blood metabolite levels; CRC cis rs10791097 0.694 rs1893017 chr11:130756253 C/T cg12179176 chr11:130786555 SNX19 0.75 12.44 0.57 2.28e-29 Autism spectrum disorder or schizophrenia;Schizophrenia; CRC cis rs889398 0.738 rs7196842 chr16:69923333 T/C cg00738113 chr16:70207722 CLEC18C -0.35 -5.65 -0.3 3.49e-8 Body mass index; CRC cis rs7586879 0.616 rs6545814 chr2:25131316 A/G cg04586622 chr2:25135609 ADCY3 -0.54 -10.13 -0.49 3.64e-21 Body mass index; CRC cis rs4713118 0.786 rs200502 chr6:27788062 C/T cg21251018 chr6:28226885 NKAPL 0.44 5.95 0.31 6.99e-9 Parkinson's disease; CRC trans rs9929218 0.559 rs11642362 chr16:68811307 T/C cg04657470 chr2:198365150 HSPE1;HSPD1 0.91 15.83 0.66 2.3e-42 Colorectal cancer; CRC cis rs11764590 0.671 rs62444906 chr7:2083161 G/T cg21155852 chr7:2048760 MAD1L1 -0.44 -5.78 -0.3 1.69e-8 Neuroticism; CRC cis rs9894429 0.634 rs9709130 chr17:79583948 C/T cg09655341 chr17:79618100 PDE6G -0.35 -6.01 -0.31 4.97e-9 Eye color traits; CRC cis rs72615157 0.595 rs112241539 chr7:99847237 C/T cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.47 5.63 0.3 3.88e-8 Lung function (FEV1/FVC); CRC cis rs853679 0.550 rs1233701 chr6:28168726 C/G cg15845792 chr6:28175446 NA -1.02 -15.98 -0.66 6.21e-43 Depression; CRC cis rs4718428 1.000 rs12534637 chr7:66327654 G/C cg18252515 chr7:66147081 NA -0.47 -6.62 -0.34 1.48e-10 Corneal structure; CRC trans rs2243480 1.000 rs466983 chr7:65520496 T/G cg10756647 chr7:56101905 PSPH 0.78 8.03 0.4 1.79e-14 Diabetic kidney disease; CRC trans rs2898857 0.504 rs35822701 chr17:47422317 C/T cg11430096 chr6:110968061 CDK19 -0.49 -7.46 -0.38 8.01e-13 Cancer; CRC cis rs875971 1.000 rs2042133 chr7:65931922 A/G cg18876405 chr7:65276391 NA 0.52 8.85 0.44 5.32e-17 Aortic root size; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg19211149 chr12:3982353 PARP11 0.37 6.26 0.33 1.22e-9 Liver disease severity in Alagille syndrome; CRC cis rs3731896 0.607 rs7600417 chr2:220169492 C/T cg00436969 chr2:220197716 RESP18 0.47 6.04 0.32 4.09e-9 Educational attainment; CRC cis rs1862618 0.573 rs2591962 chr5:56237155 G/A cg24531977 chr5:56204891 C5orf35 1.0 14.46 0.62 4.91e-37 Initial pursuit acceleration; CRC cis rs427943 0.750 rs2838803 chr21:46600126 A/G cg19498844 chr21:46707878 POFUT2;LOC642852 -0.45 -5.9 -0.31 9.19e-9 Body mass index; CRC cis rs561341 0.740 rs11080174 chr17:30208521 C/A cg12193833 chr17:30244370 NA 0.43 5.95 0.31 6.85e-9 Hip circumference adjusted for BMI; CRC cis rs7581030 0.874 rs4852772 chr2:71443645 A/G cg07678644 chr2:71558969 ZNF638 0.55 6.02 0.32 4.62e-9 Testicular germ cell tumor; CRC cis rs9522267 0.535 rs914031 chr13:112240176 C/A cg10483660 chr13:112241077 NA -0.47 -8.82 -0.44 6.62e-17 Hepatitis; CRC cis rs7177699 0.525 rs7402376 chr15:79113570 A/G cg15571903 chr15:79123663 NA -0.3 -5.77 -0.3 1.79e-8 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; CRC cis rs728616 0.764 rs56122289 chr10:81746027 G/A cg11900509 chr10:81946545 ANXA11 -0.68 -6.74 -0.35 6.97e-11 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs7613875 0.600 rs2856237 chr3:50158774 A/G cg24308560 chr3:49941425 MST1R 0.41 6.29 0.33 9.92e-10 Body mass index; CRC cis rs17021463 0.966 rs1565062 chr4:95183000 G/A cg11021082 chr4:95130006 SMARCAD1 -0.52 -7.99 -0.4 2.22e-14 Testicular germ cell tumor; CRC cis rs8141529 0.748 rs5762881 chr22:29289346 C/A cg15103426 chr22:29168792 CCDC117 0.51 7.1 0.36 7.57e-12 Lymphocyte counts; CRC cis rs1799949 1.000 rs12936831 chr17:41331816 C/T cg25072359 chr17:41440525 NA 0.43 6.44 0.33 4.32e-10 Menopause (age at onset); CRC cis rs8177179 0.967 rs4287912 chr3:133437778 A/G cg16262614 chr3:133464971 TF 0.42 7.85 0.4 6.1e-14 Iron status biomarkers (transferrin levels); CRC cis rs9435341 0.896 rs1730851 chr1:107596443 A/G cg15468180 chr1:107600409 PRMT6 -0.39 -5.86 -0.31 1.15e-8 Facial morphology (factor 21, depth of nasal alae); CRC cis rs7618915 0.547 rs13065019 chr3:52685244 T/C cg18404041 chr3:52824283 ITIH1 -0.43 -8.81 -0.44 7.22e-17 Bipolar disorder; CRC cis rs2839186 0.526 rs59977673 chr21:47922091 C/T cg13126279 chr21:47581558 C21orf56 -0.38 -5.81 -0.31 1.48e-8 Testicular germ cell tumor; CRC cis rs4665809 1.000 rs6729080 chr2:26301282 G/A cg27170947 chr2:26402098 FAM59B -0.45 -6.06 -0.32 3.68e-9 Gut microbiome composition (summer); CRC cis rs77861329 0.702 rs7644325 chr3:52081136 A/G cg08692210 chr3:52188851 WDR51A 0.49 5.82 0.31 1.36e-8 Macrophage inflammatory protein 1b levels; CRC trans rs7615952 0.673 rs3811677 chr3:125648080 G/A cg02007433 chr3:129722099 NA -0.45 -6.08 -0.32 3.24e-9 Blood pressure (smoking interaction); CRC cis rs10504229 1.000 rs56344560 chr8:58180626 C/G cg02725872 chr8:58115012 NA -0.4 -6.85 -0.35 3.63e-11 Developmental language disorder (linguistic errors); CRC cis rs9479482 1.000 rs9479481 chr6:150357944 A/G cg25797454 chr6:150327115 RAET1K 0.38 6.47 0.34 3.48e-10 Alopecia areata; CRC cis rs2404602 0.735 rs11638767 chr15:76655938 T/C cg03037974 chr15:76606532 NA -0.49 -7.32 -0.37 1.96e-12 Blood metabolite levels; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg26221423 chr11:118800852 NA 0.42 6.04 0.32 4.26e-9 Intelligence (multi-trait analysis); CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg22975147 chr17:8021903 ALOXE3 0.53 6.83 0.35 4.2e-11 Thyroid stimulating hormone; CRC trans rs2921073 0.605 rs2976933 chr8:8254875 A/G cg16141378 chr3:129829833 LOC729375 -0.53 -7.37 -0.38 1.37e-12 Parkinson's disease; CRC cis rs2239547 0.657 rs6445538 chr3:52874288 T/C cg11645453 chr3:52864694 ITIH4 0.6 10.57 0.5 1.16e-22 Schizophrenia; CRC cis rs4144743 0.941 rs7222617 chr17:45324080 G/T cg18085866 chr17:45331354 ITGB3 -0.59 -8.11 -0.41 1.02e-14 Body mass index; CRC cis rs7044106 0.762 rs1158554 chr9:123400898 G/A cg09586646 chr9:123605570 PSMD5;LOC253039 0.61 9.21 0.45 3.85e-18 Hip circumference adjusted for BMI; CRC cis rs6032067 0.929 rs6017510 chr20:43831785 A/G cg10761708 chr20:43804764 PI3 0.49 5.6 0.3 4.41e-8 Blood protein levels; CRC cis rs10486722 0.575 rs11770999 chr7:41812252 C/T cg22138096 chr7:41772439 LOC285954 0.54 6.53 0.34 2.5e-10 Pit-and-Fissure caries; CRC cis rs798554 0.723 rs798518 chr7:2777825 A/G cg14895029 chr7:2775587 GNA12 -0.42 -6.38 -0.33 6.15e-10 Height; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg05299703 chr18:43678513 ATP5A1 0.45 6.64 0.34 1.32e-10 Response to antipsychotic treatment; CRC cis rs883565 0.655 rs6599002 chr3:39076073 T/C cg01426195 chr3:39028469 NA -0.53 -8.56 -0.43 4.35e-16 Handedness; CRC cis rs6088580 0.634 rs4911421 chr20:32998948 T/C cg08999081 chr20:33150536 PIGU -0.61 -11.54 -0.54 4.11e-26 Glomerular filtration rate (creatinine); CRC trans rs61931739 0.817 rs592857 chr12:34197673 T/G cg26384229 chr12:38710491 ALG10B 0.43 5.97 0.31 5.98e-9 Morning vs. evening chronotype; CRC cis rs2455601 0.882 rs11042118 chr11:8928791 T/A cg21881798 chr11:8931708 C11orf17;ST5 -0.54 -6.08 -0.32 3.3e-9 Schizophrenia; CRC cis rs10504229 0.683 rs56192850 chr8:58135356 A/G cg04204079 chr8:58130323 NA -0.45 -5.78 -0.3 1.71e-8 Developmental language disorder (linguistic errors); CRC cis rs6662572 0.641 rs4660891 chr1:46319447 T/A cg03123370 chr1:45965343 CCDC163P;MMACHC -0.46 -5.9 -0.31 8.93e-9 Blood protein levels; CRC cis rs2280018 0.963 rs4985147 chr16:15168760 T/C cg27102117 chr16:15229624 NA 0.39 6.72 0.35 7.79e-11 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid);Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CRC cis rs2576037 0.583 rs2156049 chr18:44455717 G/A cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.62 11.0 0.52 3.53e-24 Personality dimensions; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg01189917 chr3:71633604 FOXP1 0.46 6.0 0.31 5.3e-9 Thyroid stimulating hormone; CRC cis rs4268898 1.000 rs2303294 chr2:24432620 A/G cg06627628 chr2:24431161 ITSN2 0.49 7.35 0.38 1.61e-12 Asthma; CRC cis rs838147 0.537 rs603985 chr19:49207257 T/C cg21064579 chr19:49206444 FUT2 0.49 8.53 0.43 5.31e-16 Dietary macronutrient intake; CRC trans rs11098499 0.909 rs10020034 chr4:120294331 A/G cg25214090 chr10:38739885 LOC399744 0.63 9.77 0.47 5.84e-20 Corneal astigmatism; CRC cis rs11628318 0.803 rs10138267 chr14:103035432 C/T cg02094049 chr14:103021097 NA -0.55 -7.32 -0.37 1.88e-12 Platelet count; CRC trans rs7618501 0.665 rs7621352 chr3:50070763 A/C cg21659725 chr3:3221576 CRBN -0.61 -9.69 -0.47 1.09e-19 Intelligence (multi-trait analysis); CRC cis rs1008375 1.000 rs10011865 chr4:17645710 G/A cg16339924 chr4:17578868 LAP3 0.58 7.9 0.4 4.3e-14 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs7385804 0.761 rs1734908 chr7:100313768 G/T cg20848291 chr7:100343083 ZAN 0.48 7.35 0.38 1.56e-12 Iron status biomarkers;Mean corpuscular hemoglobin;Hematocrit;Iron status biomarkers (transferrin saturation);Red blood cell count;Iron status biomarkers (iron levels);Mean corpuscular volume;Hematological parameters; CRC cis rs881375 0.715 rs11794516 chr9:123640230 A/G cg14255062 chr9:123606675 PSMD5;LOC253039 0.37 5.75 0.3 2.07e-8 Rheumatoid arthritis; CRC cis rs798554 0.679 rs2266922 chr7:2824707 G/A cg19717773 chr7:2847554 GNA12 -0.43 -7.11 -0.36 7.28e-12 Height; CRC cis rs13108904 0.518 rs4974603 chr4:1343168 C/T cg23123621 chr4:1343375 KIAA1530 0.38 6.35 0.33 7.17e-10 Obesity-related traits; CRC cis rs7666738 0.753 rs7657644 chr4:99057734 T/A cg17366294 chr4:99064904 C4orf37 0.45 7.71 0.39 1.51e-13 Colonoscopy-negative controls vs population controls; CRC cis rs12476592 0.571 rs2604617 chr2:63898663 A/G cg10828910 chr2:63850056 LOC388955 0.52 6.44 0.33 4.3e-10 Childhood ear infection; CRC cis rs6942756 0.531 rs7811141 chr7:128908273 C/G cg02491457 chr7:128862824 NA 0.53 7.73 0.39 1.36e-13 White matter hyperintensity burden; CRC cis rs875971 0.895 rs778700 chr7:65866450 C/T cg11764359 chr7:65958608 NA 0.61 9.95 0.48 1.41e-20 Aortic root size; CRC cis rs10256972 0.591 rs10229680 chr7:1158565 C/T cg23708337 chr7:1209742 NA 0.42 6.15 0.32 2.25e-9 Longevity;Endometriosis; CRC trans rs1728785 0.901 rs1183956 chr16:68606726 G/A cg04657470 chr2:198365150 HSPE1;HSPD1 0.59 7.14 0.37 6.11e-12 Ulcerative colitis; CRC cis rs8067545 0.750 rs4925069 chr17:19953531 C/G cg13482628 chr17:19912719 NA 0.47 7.39 0.38 1.22e-12 Schizophrenia; CRC trans rs7618501 0.633 rs35065728 chr3:50009176 T/C cg21659725 chr3:3221576 CRBN 0.53 8.26 0.41 3.49e-15 Intelligence (multi-trait analysis); CRC trans rs208520 0.690 rs851468 chr6:66825875 G/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.07 -14.94 -0.64 7.14e-39 Exhaled nitric oxide output; CRC cis rs2223471 0.719 rs2744489 chr6:50766781 G/A cg03432817 chr6:50765336 NA 0.39 6.26 0.33 1.21e-9 Subcutaneous adipose tissue; CRC cis rs1997103 0.954 rs6593236 chr7:55410992 C/T cg17469321 chr7:55412551 NA 0.73 11.05 0.52 2.33e-24 QRS interval (sulfonylurea treatment interaction); CRC cis rs7618501 0.521 rs55692411 chr3:49911155 G/A cg21467203 chr3:49911342 NA -0.25 -6.05 -0.32 4.01e-9 Intelligence (multi-trait analysis); CRC cis rs926938 0.608 rs360612 chr1:115394747 G/A cg12756093 chr1:115239321 AMPD1 0.58 8.6 0.43 3.29e-16 Autism; CRC cis rs2735413 0.875 rs11649082 chr16:78082256 C/T cg04733911 chr16:78082701 NA -0.45 -7.41 -0.38 1.11e-12 Systolic blood pressure (alcohol consumption interaction); CRC cis rs7666738 0.791 rs10017624 chr4:98984009 G/T cg17366294 chr4:99064904 C4orf37 0.43 7.33 0.37 1.76e-12 Colonoscopy-negative controls vs population controls; CRC cis rs270601 0.955 rs273911 chr5:131661526 C/G cg24060327 chr5:131705240 SLC22A5 -0.52 -7.83 -0.4 6.74e-14 Acylcarnitine levels; CRC cis rs853679 0.517 rs9380055 chr6:28081629 A/G cg25164649 chr6:28176230 NA 0.77 9.5 0.46 4.6e-19 Depression; CRC cis rs1552244 0.882 rs112621205 chr3:10017916 G/A cg16606324 chr3:10149918 C3orf24 0.61 7.98 0.4 2.47e-14 Alzheimer's disease; CRC cis rs2075371 0.932 rs1035328 chr7:133978419 T/C cg02659138 chr7:134003124 SLC35B4 0.39 6.76 0.35 6.49e-11 Mean platelet volume; CRC cis rs11122272 0.735 rs2486745 chr1:231505717 T/C cg06096015 chr1:231504339 EGLN1 0.4 5.95 0.31 6.7e-9 Hemoglobin concentration; CRC cis rs9916302 0.706 rs4794808 chr17:37531916 C/T cg00129232 chr17:37814104 STARD3 0.57 7.04 0.36 1.14e-11 Glomerular filtration rate (creatinine); CRC cis rs4713118 0.615 rs57252182 chr6:27720249 C/A cg08798685 chr6:27730294 NA -0.38 -5.65 -0.3 3.46e-8 Parkinson's disease; CRC cis rs12024301 0.557 rs7542136 chr1:183595057 A/G cg11505048 chr1:183622726 RGL1;APOBEC4 0.76 6.93 0.36 2.16e-11 Peripheral arterial disease (traffic-related air pollution interaction); CRC trans rs208520 0.802 rs4710314 chr6:66883656 G/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.91 -12.38 -0.56 3.59e-29 Exhaled nitric oxide output; CRC trans rs10842750 1.000 rs10842750 chr12:26690565 G/T cg15017411 chr7:106301767 FLJ36031 0.5 6.01 0.31 4.89e-9 Kashin-Beck disease; CRC cis rs6460942 0.778 rs17444259 chr7:12462428 C/T cg03579179 chr7:12444095 VWDE -0.4 -5.62 -0.3 4.06e-8 Coronary artery disease; CRC cis rs2072499 1.000 rs2540173 chr1:156188214 A/G cg25208724 chr1:156163844 SLC25A44 1.08 24.93 0.81 8.84e-78 Testicular germ cell tumor; CRC cis rs79149102 0.579 rs6495142 chr15:75320166 C/T cg09165964 chr15:75287851 SCAMP5 -0.65 -6.18 -0.32 1.88e-9 Lung cancer; CRC cis rs2404602 0.647 rs11072625 chr15:77084984 A/G cg03037974 chr15:76606532 NA 0.54 7.71 0.39 1.49e-13 Blood metabolite levels; CRC cis rs854572 1.000 rs854572 chr7:94954696 C/G cg04155289 chr7:94953770 PON1 -0.84 -15.08 -0.64 1.92e-39 Paraoxonase activity; CRC cis rs853679 0.517 rs67878650 chr6:28142587 G/C cg21251018 chr6:28226885 NKAPL 0.47 6.04 0.32 4.16e-9 Depression; CRC cis rs734999 0.545 rs12730932 chr1:2559589 T/G cg18854424 chr1:2615690 NA -0.39 -7.41 -0.38 1.05e-12 Ulcerative colitis; CRC cis rs4604732 0.631 rs11490200 chr1:247625915 G/T cg02104434 chr1:247694406 LOC148824;OR2C3 0.6 8.82 0.44 6.67e-17 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CRC cis rs9811920 0.732 rs7613864 chr3:99602470 T/C cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G 0.4 5.7 0.3 2.6e-8 Axial length; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg04769218 chr7:99098020 ZNF394 0.4 6.36 0.33 6.7e-10 Liver disease severity in Alagille syndrome; CRC cis rs7259376 0.936 rs2195964 chr19:22538338 C/T cg02657401 chr19:22469223 NA -0.33 -7.44 -0.38 8.61e-13 Menopause (age at onset); CRC cis rs1799949 0.965 rs8176140 chr17:41251646 T/A cg05368731 chr17:41323189 NBR1 0.69 10.26 0.49 1.29e-21 Menopause (age at onset); CRC cis rs904251 0.797 rs1757181 chr6:37485728 A/G cg25019722 chr6:37503610 NA 0.45 8.51 0.42 6.09e-16 Cognitive performance; CRC cis rs1799949 0.602 rs8176257 chr17:41216205 G/T cg23758822 chr17:41437982 NA 0.77 11.21 0.53 6.49e-25 Menopause (age at onset); CRC cis rs12142240 0.698 rs17357621 chr1:46807697 C/T cg00530320 chr1:46809349 NSUN4 0.58 7.98 0.4 2.46e-14 Menopause (age at onset); CRC cis rs6540559 0.673 rs6540561 chr1:209982255 C/T cg25204440 chr1:209979598 IRF6 0.48 5.83 0.31 1.35e-8 Cleft lip with or without cleft palate; CRC cis rs77633900 0.772 rs157761 chr15:76796078 C/A cg21673338 chr15:77095150 SCAPER -0.74 -6.77 -0.35 5.96e-11 Non-glioblastoma glioma;Glioma; CRC cis rs4237845 0.788 rs1962047 chr12:58292707 G/A cg00677455 chr12:58241039 CTDSP2 0.67 9.46 0.46 6.19e-19 Intelligence (multi-trait analysis); CRC cis rs853679 0.517 rs9380056 chr6:28104476 C/T cg06470822 chr6:28175283 NA 1.0 13.33 0.59 1.06e-32 Depression; CRC trans rs8085804 1.000 rs658728 chr18:40222856 C/T cg09434832 chr19:52642515 ZNF616 -0.42 -6.0 -0.31 5.1e-9 Cognitive performance; CRC cis rs9292777 0.777 rs2197428 chr5:40392200 T/C cg09067459 chr5:40385259 NA -0.57 -9.39 -0.46 1.05e-18 Crohn's disease;Multiple sclerosis; CRC trans rs3733585 0.699 rs7677710 chr4:9969517 T/G cg26043149 chr18:55253948 FECH -0.49 -7.5 -0.38 6.14e-13 Cleft plate (environmental tobacco smoke interaction); CRC cis rs2408955 0.500 rs12816820 chr12:48558325 A/G cg24011408 chr12:48396354 COL2A1 0.45 6.65 0.34 1.19e-10 Glycated hemoglobin levels; CRC cis rs7937682 0.632 rs10891294 chr11:111699224 C/T cg19812747 chr11:111475976 SIK2 0.43 6.29 0.33 9.93e-10 Primary sclerosing cholangitis; CRC cis rs8114671 0.805 rs4616 chr20:33590358 C/T cg08999081 chr20:33150536 PIGU -0.36 -5.72 -0.3 2.44e-8 Height; CRC cis rs6942756 0.806 rs2694572 chr7:128911721 A/G cg02491457 chr7:128862824 NA 0.65 9.1 0.45 9.03e-18 White matter hyperintensity burden; CRC cis rs7809950 1.000 rs987391 chr7:107100794 C/G cg23024343 chr7:107201750 COG5 -0.59 -8.6 -0.43 3.28e-16 Coronary artery disease; CRC cis rs798554 0.836 rs13243214 chr7:2817455 G/T cg19717773 chr7:2847554 GNA12 -0.47 -6.63 -0.34 1.39e-10 Height; CRC cis rs763014 0.966 rs7185390 chr16:666382 A/G cg03804128 chr16:635623 NA 0.31 7.13 0.37 6.61e-12 Height; CRC cis rs13108904 0.870 rs4974542 chr4:1250908 A/G cg16405210 chr4:1374714 KIAA1530 -0.43 -6.1 -0.32 2.91e-9 Obesity-related traits; CRC cis rs1552244 0.935 rs2272124 chr3:10138189 T/C cg00166722 chr3:10149974 C3orf24 0.63 8.79 0.44 8.71e-17 Alzheimer's disease; CRC cis rs6960043 0.905 rs11514706 chr7:15059272 A/C cg19272540 chr7:15055459 NA -0.22 -6.02 -0.31 4.78e-9 Type 2 diabetes; CRC cis rs11764590 0.715 rs55770986 chr7:2087823 T/C cg24505167 chr7:1915268 MAD1L1 -0.42 -5.8 -0.3 1.56e-8 Neuroticism; CRC cis rs6088580 0.634 rs6120644 chr20:33023810 G/A cg24642439 chr20:33292090 TP53INP2 0.36 6.12 0.32 2.61e-9 Glomerular filtration rate (creatinine); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg09328466 chr7:64023458 ZNF680 0.47 7.32 0.37 1.9e-12 Liver disease severity in Alagille syndrome; CRC cis rs798554 0.757 rs1182181 chr7:2873247 C/G cg19346786 chr7:2764209 NA -0.41 -7.06 -0.36 9.83e-12 Height; CRC cis rs1348850 0.645 rs7571386 chr2:178442687 A/C cg27490568 chr2:178487706 NA 0.43 5.9 0.31 9.03e-9 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs861020 0.582 rs630065 chr1:209998662 C/T cg05527609 chr1:210001259 C1orf107 0.8 11.12 0.52 1.36e-24 Orofacial clefts; CRC cis rs7927592 0.913 rs12284933 chr11:68319489 G/A cg01657329 chr11:68192670 LRP5 -0.46 -6.65 -0.34 1.22e-10 Total body bone mineral density; CRC cis rs7727544 0.904 rs6897575 chr5:131604535 C/T cg18758796 chr5:131593413 PDLIM4 0.33 6.18 0.32 1.88e-9 Blood metabolite levels; CRC cis rs2832077 0.527 rs2832116 chr21:30228368 C/A cg24692254 chr21:30365293 RNF160 -0.44 -6.57 -0.34 1.94e-10 Cognitive test performance; CRC cis rs4588572 0.570 rs2115433 chr5:77700363 C/T cg11547950 chr5:77652471 NA -0.5 -7.43 -0.38 9.69e-13 Triglycerides; CRC cis rs9487051 0.735 rs1260595 chr6:109519873 T/G cg21918786 chr6:109611834 NA -0.35 -6.01 -0.31 4.88e-9 Reticulocyte fraction of red cells; CRC cis rs1983170 1.000 rs12563578 chr1:91993702 T/C cg21854759 chr1:92012499 NA 0.49 6.31 0.33 9.08e-10 Eosinophil percentage of white cells; CRC cis rs1552244 0.938 rs7647987 chr3:10140696 A/G cg00166722 chr3:10149974 C3orf24 0.63 8.78 0.44 9.09e-17 Alzheimer's disease; CRC cis rs561341 0.941 rs8081016 chr17:30331751 A/G cg23018236 chr17:30244563 NA -0.67 -8.01 -0.4 1.96e-14 Hip circumference adjusted for BMI; CRC cis rs9549328 0.611 rs72661939 chr13:113617498 C/T cg25790453 chr13:113633590 MCF2L 0.44 7.62 0.39 2.7e-13 Systolic blood pressure; CRC cis rs13108904 0.517 rs13134568 chr4:1334289 G/A cg02018176 chr4:1364513 KIAA1530 0.39 5.73 0.3 2.22e-8 Obesity-related traits; CRC cis rs4423214 1.000 rs12789751 chr11:71164471 G/A cg05163923 chr11:71159392 DHCR7 0.66 9.42 0.46 8.42e-19 Vitamin D levels; CRC cis rs2625529 0.652 rs2957736 chr15:72265344 A/G cg16672083 chr15:72433130 SENP8 0.47 7.1 0.36 7.52e-12 Red blood cell count; CRC cis rs4665809 0.549 rs62130460 chr2:26472718 T/C cg08067268 chr2:26466485 HADHB;HADHA 0.62 7.3 0.37 2.2e-12 Gut microbiome composition (summer); CRC cis rs6121246 0.523 rs6060286 chr20:30197663 C/A cg18721089 chr20:30220636 NA -0.52 -7.93 -0.4 3.54e-14 Mean corpuscular hemoglobin; CRC cis rs1971762 0.527 rs7976398 chr12:54028862 T/C cg06632207 chr12:54070931 ATP5G2 0.49 8.48 0.42 7.63e-16 Height; CRC cis rs853679 0.760 rs9295768 chr6:28209102 G/A cg15845792 chr6:28175446 NA 0.74 7.78 0.39 9.45e-14 Depression; CRC trans rs9583531 0.629 rs7991766 chr13:111380684 A/G cg20064139 chr20:41823021 NA -0.29 -6.07 -0.32 3.54e-9 Coronary artery disease; CRC cis rs1797081 0.811 rs1797076 chr10:16853076 A/G cg23933602 chr10:16859644 RSU1 0.84 14.28 0.62 2.46e-36 Platelet distribution width; CRC cis rs4819052 0.851 rs2236443 chr21:46678174 T/C cg19498844 chr21:46707878 POFUT2;LOC642852 0.72 10.34 0.5 7.15e-22 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs58688157 0.705 rs12419694 chr11:598033 C/T cg09218773 chr11:619014 MUPCDH -0.46 -6.89 -0.36 2.82e-11 Systemic lupus erythematosus; CRC cis rs853679 0.517 rs9368550 chr6:28051803 T/A cg06470822 chr6:28175283 NA 0.98 13.22 0.59 2.69e-32 Depression; CRC cis rs2204008 0.570 rs12318341 chr12:38251087 T/C cg26384229 chr12:38710491 ALG10B -0.51 -7.39 -0.38 1.25e-12 Bladder cancer; CRC cis rs2576037 0.901 rs2576036 chr18:44587102 G/T cg19077165 chr18:44547161 KATNAL2 -0.47 -7.75 -0.39 1.16e-13 Personality dimensions; CRC cis rs10504229 0.610 rs7840469 chr8:58146992 C/T cg22535103 chr8:58192502 C8orf71 -0.66 -9.47 -0.46 5.76e-19 Developmental language disorder (linguistic errors); CRC cis rs7705042 0.897 rs7718955 chr5:141521459 A/G cg07392085 chr5:141489673 NDFIP1 0.45 7.25 0.37 2.94e-12 Asthma; CRC cis rs7512552 0.803 rs9436125 chr1:150487961 C/G cg15654264 chr1:150340011 RPRD2 0.59 7.86 0.4 5.49e-14 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); CRC cis rs7178572 0.568 rs11632941 chr15:77533888 A/G cg22256960 chr15:77711686 NA -0.67 -9.72 -0.47 8.52e-20 Type 2 diabetes; CRC cis rs11997175 0.583 rs4386938 chr8:33673156 A/G cg04338863 chr8:33670619 NA 0.38 6.17 0.32 2.01e-9 Body mass index; CRC cis rs11583043 0.667 rs873760 chr1:101540561 C/A cg16556008 chr1:101360663 SLC30A7;EXTL2 0.45 5.7 0.3 2.61e-8 Ulcerative colitis;Inflammatory bowel disease; CRC cis rs7666738 0.830 rs11097609 chr4:99011707 C/T cg05340658 chr4:99064831 C4orf37 0.62 9.64 0.47 1.5700000000000001e-19 Colonoscopy-negative controls vs population controls; CRC cis rs9311474 0.629 rs7639267 chr3:52568805 G/T cg13284614 chr3:52569169 NT5DC2;LOC440957 0.37 6.1 0.32 2.93e-9 Electroencephalogram traits; CRC cis rs3020333 0.875 rs2941741 chr6:152008982 G/A cg22157087 chr6:152012887 ESR1 0.52 7.64 0.39 2.37e-13 Total body bone mineral density; CRC trans rs79243044 0.786 rs16932549 chr11:5560909 C/T cg00145849 chr4:39699494 UBE2K -0.46 -6.38 -0.33 6.09e-10 QRS duration in Tripanosoma cruzi seropositivity; CRC cis rs3617 0.591 rs11918800 chr3:52868145 G/A cg11645453 chr3:52864694 ITIH4 -0.46 -9.14 -0.45 6.83e-18 Red blood cell count;Autism spectrum disorder or schizophrenia; CRC cis rs11252926 0.537 rs6560836 chr10:444997 C/T cg16386425 chr10:429943 DIP2C -0.44 -6.67 -0.35 1.07e-10 Psychosis in Alzheimer's disease; CRC cis rs1707322 0.821 rs11211182 chr1:46240170 G/A cg06784218 chr1:46089804 CCDC17 0.61 10.94 0.52 5.61e-24 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs1256061 0.630 rs1256030 chr14:64747170 A/G cg23250157 chr14:64679961 SYNE2 0.35 5.72 0.3 2.36e-8 Hemoglobin concentration;Red blood cell count;Hematocrit; CRC cis rs1499614 0.901 rs3936 chr7:66126489 C/T cg25985355 chr7:65971099 NA -0.51 -5.91 -0.31 8.44e-9 Gout; CRC cis rs10924970 0.935 rs12731746 chr1:235392546 T/C cg26050004 chr1:235667680 B3GALNT2 0.39 5.78 0.3 1.71e-8 Asthma; CRC cis rs13191362 1.000 rs7764785 chr6:163009967 A/G cg21926612 chr6:163149169 PACRG;PARK2 0.78 10.8 0.51 1.77e-23 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs2361718 0.933 rs8066452 chr17:78104080 A/G cg24585782 chr17:78113791 EIF4A3 -0.37 -5.71 -0.3 2.56e-8 Yeast infection; CRC cis rs17270561 0.636 rs1185977 chr6:25829054 A/G cg16482183 chr6:26056742 HIST1H1C 0.54 7.34 0.38 1.71e-12 Iron status biomarkers; CRC cis rs875971 0.638 rs801216 chr7:66011667 T/C cg00343986 chr7:65444356 GUSB -0.49 -7.42 -0.38 1e-12 Aortic root size; CRC cis rs3617 0.652 rs7630552 chr3:52891570 G/C cg11645453 chr3:52864694 ITIH4 -0.45 -8.97 -0.44 2.32e-17 Red blood cell count;Autism spectrum disorder or schizophrenia; CRC cis rs17711722 0.675 rs6947132 chr7:65273495 G/A cg00343986 chr7:65444356 GUSB -0.57 -8.59 -0.43 3.53e-16 Calcium levels; CRC cis rs7149337 0.805 rs3007069 chr14:51597392 G/A cg18683604 chr14:51561293 TRIM9 0.3 6.11 0.32 2.84e-9 Cancer; CRC trans rs2797160 1.000 rs1739349 chr6:126014984 G/C cg05039488 chr6:79577232 IRAK1BP1 0.51 7.59 0.39 3.37e-13 Endometrial cancer; CRC cis rs801193 0.613 rs2016325 chr7:66323500 T/C cg11764359 chr7:65958608 NA -0.45 -6.49 -0.34 3.17e-10 Aortic root size; CRC cis rs7172677 1.000 rs4479194 chr15:75422131 C/T cg14664628 chr15:75095509 CSK -0.47 -5.68 -0.3 2.93e-8 Systemic lupus erythematosus and Systemic sclerosis; CRC cis rs13108904 0.870 rs13110563 chr4:1255772 G/C cg20887711 chr4:1340912 KIAA1530 0.41 5.77 0.3 1.81e-8 Obesity-related traits; CRC cis rs34779708 0.966 rs6481941 chr10:35440141 G/A cg03585969 chr10:35415529 CREM 0.56 7.56 0.38 3.96e-13 Inflammatory bowel disease;Crohn's disease; CRC cis rs7312774 0.881 rs7309260 chr12:107313254 T/A cg16260113 chr12:107380972 MTERFD3 0.74 7.49 0.38 6.31e-13 Severe influenza A (H1N1) infection; CRC cis rs4423214 0.879 rs1792277 chr11:71138918 C/T cg13043300 chr11:71146211 DHCR7 -0.47 -6.39 -0.33 5.76e-10 Vitamin D levels; CRC trans rs6545883 0.929 rs6545873 chr2:61733012 T/C cg11704114 chr12:21509398 SLCO1A2 -0.33 -6.14 -0.32 2.37e-9 Tuberculosis; CRC cis rs2404602 0.735 rs62028423 chr15:76754514 G/A cg23625390 chr15:77176239 SCAPER -0.88 -14.04 -0.61 1.99e-35 Blood metabolite levels; CRC cis rs11608355 0.597 rs10850070 chr12:109793882 A/G cg19025524 chr12:109796872 NA -0.62 -10.1 -0.49 4.72e-21 Neuroticism; CRC cis rs911555 0.755 rs12432803 chr14:103930032 C/T cg24130564 chr14:104152367 KLC1 0.42 5.76 0.3 1.93e-8 Intelligence (multi-trait analysis); CRC cis rs1865760 0.820 rs9348697 chr6:25890834 C/T cg17691542 chr6:26056736 HIST1H1C 0.5 7.62 0.39 2.79e-13 Height; CRC cis rs6831352 0.918 rs1042364 chr4:100045574 T/C cg12011299 chr4:100065546 ADH4 0.5 9.54 0.47 3.24e-19 Alcohol dependence; CRC cis rs9937943 0.673 rs12922972 chr16:74494522 T/A cg01733217 chr16:74700730 RFWD3 0.71 7.9 0.4 4.16e-14 Neutrophil percentage of white cells; CRC cis rs9287719 0.578 rs62127189 chr2:10761326 T/C cg00105475 chr2:10696890 NA 0.45 6.93 0.36 2.3e-11 Prostate cancer; CRC cis rs9611565 0.592 rs4481089 chr22:41980892 T/C cg03806693 chr22:41940476 POLR3H -0.74 -9.51 -0.46 4.03e-19 Vitiligo; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg04474326 chr20:57556688 TH1L 0.44 6.23 0.32 1.43e-9 Intelligence (multi-trait analysis); CRC cis rs4794106 0.792 rs847682 chr17:48208274 C/T cg13127421 chr17:48202128 SAMD14 -0.56 -9.56 -0.47 2.82e-19 Temporomandibular joint disorder; CRC cis rs3736594 0.513 rs6547735 chr2:27831607 T/C cg27432699 chr2:27873401 GPN1 0.62 8.28 0.42 3.12e-15 Fasting blood glucose;Fasting blood glucose (BMI interaction); CRC cis rs7789940 0.951 rs73140055 chr7:75975777 A/T cg10167463 chr7:75959203 YWHAG -0.79 -11.37 -0.53 1.7e-25 Multiple sclerosis; CRC cis rs7703744 0.681 rs73239278 chr5:118695051 G/A cg23917399 chr5:118691751 TNFAIP8 0.41 5.69 0.3 2.8e-8 Lobe attachment (rater-scored or self-reported); CRC cis rs2976388 1.000 rs2976398 chr8:143764879 G/C cg22687807 chr8:143858763 LYNX1 -0.39 -6.8 -0.35 4.8e-11 Urinary tract infection frequency; CRC cis rs477895 0.653 rs2875749 chr11:63903878 C/A cg18225595 chr11:63971243 STIP1 0.57 7.54 0.38 4.59e-13 Mean platelet volume; CRC cis rs7772486 0.686 rs9497380 chr6:145955305 T/C cg13319975 chr6:146136371 FBXO30 -0.41 -6.14 -0.32 2.43e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs79349575 0.783 rs318090 chr17:46991752 G/A cg22482690 chr17:47019901 SNF8 0.48 8.06 0.41 1.48e-14 Type 2 diabetes; CRC cis rs2019137 0.560 rs7578633 chr2:113978650 C/T cg23564664 chr2:113997917 PAX8;LOC654433;LOC440839 -0.37 -5.93 -0.31 7.66e-9 Lymphocyte counts; CRC cis rs919433 0.927 rs13032495 chr2:198189346 C/T cg10820045 chr2:198174542 NA -0.52 -8.93 -0.44 3.1e-17 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC cis rs2011503 0.941 rs55822665 chr19:19383298 C/T cg11584989 chr19:19387371 SF4 0.57 6.62 0.34 1.48e-10 Bipolar disorder; CRC cis rs3796352 1.000 rs34313969 chr3:52995166 A/G cg07884673 chr3:53033167 SFMBT1 0.7 6.15 0.32 2.23e-9 Immune reponse to smallpox (secreted IL-2); CRC cis rs1799949 1.000 rs4793212 chr17:41302750 T/C cg23758822 chr17:41437982 NA 0.8 13.44 0.6 3.93e-33 Menopause (age at onset); CRC cis rs1971762 0.583 rs7979659 chr12:54086579 A/G cg06632207 chr12:54070931 ATP5G2 0.41 6.98 0.36 1.63e-11 Height; CRC cis rs6933660 0.646 rs9397051 chr6:151778325 C/T cg17179660 chr6:151773299 C6orf211;RMND1 -0.44 -6.81 -0.35 4.64e-11 Menarche (age at onset); CRC cis rs11122272 0.735 rs2247124 chr1:231493687 A/G cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.6 -9.07 -0.45 1.09e-17 Hemoglobin concentration; CRC cis rs7586879 0.828 rs1968482 chr2:25086858 T/C cg04586622 chr2:25135609 ADCY3 -0.55 -9.43 -0.46 7.75e-19 Body mass index; CRC trans rs10050311 0.698 rs17454154 chr4:87636160 A/G cg00004207 chr2:38977301 SFRS7 0.5 6.07 0.32 3.56e-9 Insulin-related traits; CRC cis rs7224737 1.000 rs11079034 chr17:40288890 G/A cg00647820 chr17:40259828 DHX58 -0.45 -6.51 -0.34 2.74e-10 Fibrinogen levels; CRC cis rs1499614 1.000 rs2707838 chr7:66159201 C/T cg25985355 chr7:65971099 NA -0.52 -5.92 -0.31 7.91e-9 Gout; CRC cis rs9399135 0.967 rs4896122 chr6:135295081 T/C cg22676075 chr6:135203613 NA 0.43 6.69 0.35 9.9e-11 Red blood cell count; CRC cis rs2302729 0.545 rs10161181 chr12:2770730 A/C cg19945202 chr12:2788847 CACNA1C -0.44 -7.28 -0.37 2.49e-12 Sleep quality; CRC cis rs1552244 0.882 rs3755783 chr3:10029289 A/G cg13047869 chr3:10149882 C3orf24 0.49 6.25 0.33 1.24e-9 Alzheimer's disease; CRC cis rs10883723 0.810 rs2296586 chr10:104245575 C/T cg11453585 chr10:104263688 ACTR1A;SUFU 0.9 16.89 0.68 1.61e-46 Allergic disease (asthma, hay fever or eczema); CRC cis rs4964805 0.913 rs3812803 chr12:104200460 T/C cg02344784 chr12:104178138 NT5DC3 0.53 7.71 0.39 1.49e-13 Attention deficit hyperactivity disorder; CRC cis rs4481887 0.927 rs12039929 chr1:248482018 G/A cg00666640 chr1:248458726 OR2T12 0.49 8.34 0.42 2.08e-15 Common traits (Other); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg11316784 chr5:176560594 NSD1 0.4 6.01 0.31 4.88e-9 Intelligence (multi-trait analysis); CRC cis rs875971 0.862 rs3926380 chr7:66080645 G/T cg00343986 chr7:65444356 GUSB -0.46 -6.27 -0.33 1.16e-9 Aortic root size; CRC cis rs7493 0.755 rs34774523 chr7:94962142 G/A cg17330251 chr7:94953956 PON1 -0.51 -6.6 -0.34 1.61e-10 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs951366 0.589 rs823099 chr1:205669322 C/A cg11965913 chr1:205819406 PM20D1 0.83 12.58 0.57 6.53e-30 Menarche (age at onset); CRC cis rs10208940 0.764 rs6737186 chr2:68782763 A/C cg12452813 chr2:68675892 NA 0.46 5.71 0.3 2.48e-8 Urate levels in lean individuals; CRC cis rs72781680 1.000 rs56104215 chr2:24133590 T/C cg08917208 chr2:24149416 ATAD2B 0.91 9.24 0.45 3.06e-18 Lymphocyte counts; CRC cis rs735539 1.000 rs9506537 chr13:21280410 T/C cg04906043 chr13:21280425 IL17D 0.46 7.29 0.37 2.3e-12 Dental caries; CRC cis rs597583 0.715 rs11216437 chr11:117394685 A/G cg27161313 chr11:117392002 DSCAML1 0.47 6.11 0.32 2.78e-9 Putamen volume; CRC cis rs2276314 0.857 rs8097597 chr18:33619448 A/G cg19628046 chr18:33552617 C18orf21 0.51 7.25 0.37 2.92e-12 Endometriosis;Drug-induced torsades de pointes; CRC cis rs1862618 0.671 rs173763 chr5:56225418 G/A cg12311346 chr5:56204834 C5orf35 -0.66 -9.78 -0.47 5.53e-20 Initial pursuit acceleration; CRC cis rs1153858 1.000 rs4775907 chr15:45638647 G/A cg10760299 chr15:45669010 GATM 0.5 7.99 0.4 2.37e-14 Homoarginine levels; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg06153298 chr16:88851960 FAM38A 0.44 5.96 0.31 6.38e-9 Anxiety disorder; CRC cis rs7552404 0.696 rs12140121 chr1:76455001 A/G cg22875332 chr1:76189707 ACADM 0.61 7.36 0.38 1.48e-12 Blood metabolite levels;Acylcarnitine levels; CRC trans rs7618501 0.540 rs11130241 chr3:50131459 A/T cg21665057 chr3:196295764 WDR53;FBXO45 -0.62 -9.86 -0.48 2.97e-20 Intelligence (multi-trait analysis); CRC cis rs10971721 0.822 rs117733169 chr9:33938099 A/T cg13495928 chr9:33750294 PRSS3 0.56 5.95 0.31 6.96e-9 Body mass index; CRC cis rs9487051 0.676 rs1608041 chr6:109595903 G/A cg21918786 chr6:109611834 NA -0.41 -7.17 -0.37 4.84e-12 Reticulocyte fraction of red cells; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg15459742 chr9:111775564 CTNNAL1 0.47 6.1 0.32 3.05e-9 Thyroid stimulating hormone; CRC cis rs7927592 0.956 rs11228251 chr11:68244558 G/T cg01657329 chr11:68192670 LRP5 -0.49 -7.47 -0.38 7.44e-13 Total body bone mineral density; CRC cis rs4713118 0.869 rs9283881 chr6:27715255 A/T cg12273811 chr6:28175739 NA 0.54 7.72 0.39 1.43e-13 Parkinson's disease; CRC cis rs2404602 0.669 rs1875885 chr15:76638081 G/A cg03037974 chr15:76606532 NA 0.72 12.65 0.57 3.7e-30 Blood metabolite levels; CRC cis rs1865760 0.573 rs7450342 chr6:25919480 T/C cg03264133 chr6:25882463 NA -0.45 -6.7 -0.35 9e-11 Height; CRC cis rs4474465 0.833 rs7934912 chr11:78218556 A/T cg27205649 chr11:78285834 NARS2 0.47 5.76 0.3 1.94e-8 Alzheimer's disease (survival time); CRC trans rs7618501 1.000 rs4855867 chr3:49745822 C/T cg21665057 chr3:196295764 WDR53;FBXO45 -0.86 -16.09 -0.66 2.29e-43 Intelligence (multi-trait analysis); CRC cis rs4853036 0.951 rs35344582 chr2:70148093 C/T cg02498382 chr2:70120550 SNRNP27 -0.41 -5.84 -0.31 1.27e-8 Colorectal or endometrial cancer; CRC cis rs9322193 0.772 rs7738696 chr6:150170121 A/G cg13206674 chr6:150067644 NUP43 0.61 8.97 0.44 2.34e-17 Lung cancer; CRC cis rs6088590 1.000 rs6088607 chr20:33378733 C/T cg08999081 chr20:33150536 PIGU 0.51 8.54 0.43 5.01e-16 Coronary artery disease; CRC cis rs6735179 0.607 rs10188708 chr2:1746032 G/C cg19300414 chr2:1746591 PXDN 0.47 7.92 0.4 3.71e-14 Response to antipsychotic treatment; CRC cis rs8180040 0.764 rs11716539 chr3:47186503 G/T cg27129171 chr3:47204927 SETD2 0.76 13.13 0.59 6.08e-32 Colorectal cancer; CRC cis rs7618501 0.633 rs2883057 chr3:49998282 C/T cg05623727 chr3:50126028 RBM5 0.47 7.72 0.39 1.43e-13 Intelligence (multi-trait analysis); CRC trans rs559356 0.519 rs475330 chr3:34841244 A/G cg18960307 chr17:4699574 PSMB6 -0.4 -5.96 -0.31 6.47e-9 Cognitive function; CRC cis rs4713118 0.869 rs9283881 chr6:27715255 A/T cg02683197 chr6:28174875 NA 0.63 8.77 0.44 1e-16 Parkinson's disease; CRC trans rs4942242 0.640 rs17460861 chr13:44230078 C/G cg27382691 chr15:76552771 ETFA;TYRO3P 0.47 6.03 0.32 4.47e-9 Response to tocilizumab in rheumatoid arthritis; CRC cis rs6681460 0.898 rs1032635 chr1:67195184 C/G cg02459107 chr1:67143332 SGIP1 -0.4 -6.83 -0.35 4.2e-11 Presence of antiphospholipid antibodies; CRC cis rs35306767 0.761 rs11253560 chr10:1047226 T/G cg26597838 chr10:835615 NA 0.94 11.17 0.52 8.94e-25 Eosinophil percentage of granulocytes; CRC trans rs561341 0.941 rs8081016 chr17:30331751 A/G cg27661571 chr11:113659931 NA -0.94 -10.92 -0.52 7.04e-24 Hip circumference adjusted for BMI; CRC cis rs6499255 0.951 rs1437135 chr16:69757828 A/G cg04110750 chr16:69646130 NFAT5 -0.54 -7.34 -0.38 1.66e-12 IgE levels; CRC cis rs12431939 0.817 rs7153408 chr14:51671492 G/A cg23942311 chr14:51606299 NA 0.49 6.74 0.35 7.02e-11 Cancer; CRC cis rs2836950 0.565 rs8130320 chr21:40580258 C/T cg11644478 chr21:40555479 PSMG1 -0.49 -7.5 -0.38 5.96e-13 Menarche (age at onset); CRC cis rs17253792 0.822 rs28481586 chr14:56053863 C/G cg24579896 chr14:56047964 C14orf33;KTN1 0.67 5.7 0.3 2.61e-8 Putamen volume; CRC trans rs9329221 0.683 rs525726 chr8:9887797 G/C cg06636001 chr8:8085503 FLJ10661 -0.53 -8.16 -0.41 7.4e-15 Neuroticism; CRC cis rs523522 0.962 rs10774549 chr12:120891172 C/T cg27279351 chr12:120934652 DYNLL1 0.78 11.12 0.52 1.3e-24 High light scatter reticulocyte count; CRC cis rs7209700 0.662 rs11656865 chr17:45346489 A/G cg08085267 chr17:45401833 C17orf57 0.44 5.96 0.31 6.44e-9 IgG glycosylation; CRC cis rs769267 0.930 rs2099334 chr19:19578450 A/G cg02546618 chr19:19431379 KIAA0892;SF4 0.45 6.19 0.32 1.78e-9 Tonsillectomy; CRC cis rs11122272 0.735 rs910824 chr1:231498773 C/G cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.53 -8.11 -0.41 1.03e-14 Hemoglobin concentration; CRC cis rs728616 0.867 rs61860043 chr10:81946398 G/A cg11900509 chr10:81946545 ANXA11 -0.72 -7.26 -0.37 2.88e-12 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs7703744 0.634 rs73237292 chr5:118688520 A/T cg23985447 chr5:118691066 TNFAIP8 0.41 6.04 0.32 4.2e-9 Lobe attachment (rater-scored or self-reported); CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg07518035 chr19:54693944 MBOAT7;TSEN34 0.46 6.16 0.32 2.13e-9 Anxiety disorder; CRC cis rs3751196 0.808 rs55736751 chr12:104217303 T/G cg02344784 chr12:104178138 NT5DC3 0.71 7.54 0.38 4.58e-13 Sense of smell; CRC cis rs8180040 0.800 rs11130126 chr3:47306894 A/G cg02527881 chr3:46936655 PTH1R 0.36 6.19 0.32 1.75e-9 Colorectal cancer; CRC cis rs524281 0.861 rs10896095 chr11:65962560 A/G cg16950941 chr11:66035639 RAB1B -0.58 -7.17 -0.37 5.08e-12 Electroencephalogram traits; CRC cis rs736408 0.634 rs11717836 chr3:52807736 A/G cg18404041 chr3:52824283 ITIH1 -0.44 -8.73 -0.43 1.31e-16 Bipolar disorder; CRC cis rs11098499 0.909 rs10026736 chr4:120384322 G/C cg09307838 chr4:120376055 NA 0.73 11.02 0.52 3.13e-24 Corneal astigmatism; CRC cis rs72945132 0.882 rs66627443 chr11:70199036 C/G cg00319359 chr11:70116639 PPFIA1 0.55 6.04 0.32 4.16e-9 Coronary artery disease; CRC cis rs2562152 0.706 rs216596 chr16:105320 A/G cg02949481 chr16:131562 MPG 0.58 6.75 0.35 6.67e-11 Glioblastoma; CRC cis rs1552244 0.572 rs17032426 chr3:10167112 G/A cg13047869 chr3:10149882 C3orf24 0.54 6.49 0.34 3.1e-10 Alzheimer's disease; CRC cis rs13082711 0.516 rs1388785 chr3:27371843 T/C cg02860705 chr3:27208620 NA -0.54 -7.66 -0.39 2.09e-13 Systolic blood pressure;Diastolic blood pressure;Blood pressure; CRC cis rs7523050 0.643 rs71655970 chr1:109403895 A/G cg08274380 chr1:109419600 GPSM2 0.85 6.65 0.34 1.24e-10 Fat distribution (HIV); CRC cis rs2842992 0.789 rs2342446 chr6:160220687 A/G cg19482086 chr6:160211437 TCP1;MRPL18 0.74 9.59 0.47 2.24e-19 Age-related macular degeneration (geographic atrophy); CRC cis rs4713118 0.869 rs7773070 chr6:27728827 T/C cg15845792 chr6:28175446 NA 0.66 9.23 0.45 3.49e-18 Parkinson's disease; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg13857382 chr1:175162153 KIAA0040 0.47 6.4 0.33 5.44e-10 Anxiety disorder; CRC cis rs3749237 0.595 rs17595772 chr3:49409704 G/A cg03060546 chr3:49711283 APEH 0.6 10.25 0.49 1.36e-21 Resting heart rate; CRC cis rs6604026 0.656 rs2774956 chr1:93364726 A/G cg17283838 chr1:93427260 FAM69A -0.43 -5.8 -0.3 1.52e-8 Multiple sclerosis; CRC cis rs4144743 0.759 rs67972765 chr17:45318326 G/A cg18085866 chr17:45331354 ITGB3 -0.52 -6.1 -0.32 2.91e-9 Body mass index; CRC cis rs4481887 0.893 rs11204632 chr1:248479532 G/A cg13385794 chr1:248469461 NA 0.39 6.73 0.35 7.54e-11 Common traits (Other); CRC cis rs11098499 0.954 rs12510138 chr4:120423935 C/G cg24375607 chr4:120327624 NA 0.52 8.06 0.41 1.41e-14 Corneal astigmatism; CRC cis rs611744 0.647 rs11774904 chr8:109273435 G/A cg18478394 chr8:109455254 TTC35 0.4 6.23 0.32 1.4e-9 Dupuytren's disease; CRC trans rs4853036 0.586 rs35066995 chr2:70005544 T/C cg14633329 chr9:139640053 LCN6 -0.39 -6.44 -0.33 4.13e-10 Colorectal or endometrial cancer; CRC cis rs9420 0.961 rs12146541 chr11:57508678 G/C cg23127183 chr11:57508653 C11orf31 -0.53 -7.22 -0.37 3.69e-12 Schizophrenia; CRC cis rs13108904 0.935 rs13148614 chr4:1248357 G/C cg19318889 chr4:1322082 MAEA 0.47 6.96 0.36 1.81e-11 Obesity-related traits; CRC cis rs1003719 0.679 rs2835638 chr21:38534533 T/C cg10648535 chr21:38446584 PIGP;TTC3 -0.48 -6.67 -0.35 1.08e-10 Eye color traits; CRC cis rs4664293 0.546 rs7564399 chr2:160632119 C/T cg08347373 chr2:160653686 CD302 0.43 7.42 0.38 1.03e-12 Monocyte percentage of white cells; CRC trans rs7944735 0.507 rs10742827 chr11:48102350 C/T cg03929089 chr4:120376271 NA 0.58 7.47 0.38 7.18e-13 Intraocular pressure; CRC cis rs875971 0.895 rs10755833 chr7:65913917 A/G cg18912574 chr7:65842487 NCRNA00174 0.36 6.1 0.32 2.97e-9 Aortic root size; CRC cis rs3785574 0.962 rs4480868 chr17:61788859 C/T cg23090583 chr17:61904693 PSMC5;FTSJ3 0.61 8.95 0.44 2.57e-17 Height; CRC cis rs1580019 0.547 rs56981934 chr7:32535202 C/G cg14728415 chr7:32535168 LSM5;AVL9 0.49 7.15 0.37 5.54e-12 Cognitive ability; CRC cis rs12142240 0.667 rs55887761 chr1:46826587 C/A cg00530320 chr1:46809349 NSUN4 0.59 8.03 0.41 1.69e-14 Menopause (age at onset); CRC cis rs10242455 0.702 rs73403286 chr7:99154865 A/C cg18809830 chr7:99032528 PTCD1 -1.21 -8.72 -0.43 1.36e-16 Blood metabolite levels; CRC trans rs10982213 0.830 rs2274163 chr9:117188714 C/T cg22583711 chr7:154795321 PAXIP1;LOC202781 0.41 6.49 0.34 3.12e-10 Interleukin-6 levels; CRC cis rs7584330 0.518 rs77789507 chr2:238440972 C/T cg14458575 chr2:238380390 NA 0.81 10.19 0.49 2.33e-21 Prostate cancer; CRC cis rs780096 0.546 rs6547626 chr2:27646770 C/T cg12648201 chr2:27665141 KRTCAP3 -0.29 -5.83 -0.31 1.3e-8 Total body bone mineral density; CRC cis rs863345 0.565 rs7551497 chr1:158444925 T/G cg12129480 chr1:158549410 OR10X1 -0.29 -5.94 -0.31 7.45e-9 Pneumococcal bacteremia; CRC cis rs13108904 0.967 rs900028 chr4:1279162 A/T cg16405210 chr4:1374714 KIAA1530 -0.44 -6.06 -0.32 3.72e-9 Obesity-related traits; CRC cis rs6741819 1.000 rs3755509 chr2:7144838 A/G cg27144453 chr2:7172511 RNF144A -0.42 -6.24 -0.33 1.38e-9 Response to antipsychotic treatment; CRC cis rs1223397 0.651 rs2496142 chr6:13311794 C/T cg20827128 chr6:13274284 PHACTR1 -0.38 -5.77 -0.3 1.83e-8 Blood pressure; CRC cis rs780096 0.506 rs1647285 chr2:27714511 A/C cg21248554 chr2:27665150 KRTCAP3 -0.36 -8.41 -0.42 1.24e-15 Total body bone mineral density; CRC trans rs2243480 1.000 rs36033484 chr7:65390558 T/G cg10756647 chr7:56101905 PSPH 0.7 7.47 0.38 7.51e-13 Diabetic kidney disease; CRC cis rs7953249 1.000 rs7953249 chr12:121403724 A/G cg02403541 chr12:121454288 C12orf43 0.39 5.86 0.31 1.14e-8 Invasive epithelial ovarian cancer;High-grade serous ovarian cancer;Chronic obstructive pulmonary disease-related biomarkers;N-glycan levels;Serous invasive ovarian cancer;Epithelial ovarian cancer; CRC cis rs3617 0.573 rs9810807 chr3:52924227 C/T cg15147215 chr3:52552868 STAB1 0.43 7.25 0.37 2.93e-12 Red blood cell count;Autism spectrum disorder or schizophrenia; CRC trans rs7395662 0.895 rs3903506 chr11:48718513 G/A cg21153622 chr11:89784906 NA 0.46 7.41 0.38 1.05e-12 HDL cholesterol; CRC cis rs9814567 0.727 rs4437193 chr3:134352344 A/G cg06109529 chr3:134205091 CEP63;ANAPC13 -0.62 -8.82 -0.44 6.83e-17 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs7647973 1.000 rs10865956 chr3:49581559 C/A cg07690219 chr3:49449608 TCTA;RHOA -0.55 -6.31 -0.33 8.76e-10 Menarche (age at onset); CRC cis rs67340775 0.541 rs200979 chr6:27852357 G/A cg03623178 chr6:28175578 NA 0.88 9.03 0.45 1.48e-17 Lung cancer in ever smokers; CRC cis rs4332037 0.722 rs7788921 chr7:1915282 C/A cg25834613 chr7:1915315 MAD1L1 -0.51 -7.94 -0.4 3.14e-14 Bipolar disorder; CRC cis rs9487051 0.652 rs6568559 chr6:109592751 C/T cg01475377 chr6:109611718 NA -0.39 -6.89 -0.36 2.77e-11 Reticulocyte fraction of red cells; CRC cis rs7772486 0.686 rs1337841 chr6:146059487 A/G cg13319975 chr6:146136371 FBXO30 0.44 6.65 0.34 1.21e-10 Lobe attachment (rater-scored or self-reported); CRC cis rs929354 0.685 rs7807856 chr7:156934498 T/C cg16102536 chr7:156981717 UBE3C 0.4 6.69 0.35 9.57e-11 Body mass index; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg21490793 chr19:38827205 CATSPERG 0.43 5.99 0.31 5.4e-9 Response to antipsychotic treatment; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg17367356 chr11:45907078 MAPK8IP1 0.34 6.06 0.32 3.78e-9 Liver disease severity in Alagille syndrome; CRC cis rs9916302 0.904 rs4794814 chr17:37696852 G/A cg07936489 chr17:37558343 FBXL20 -0.83 -13.0 -0.58 1.88e-31 Glomerular filtration rate (creatinine); CRC cis rs13161895 0.713 rs76315806 chr5:179485515 C/G cg02702477 chr5:179499311 RNF130 0.7 7.65 0.39 2.3e-13 LDL cholesterol; CRC cis rs1707322 0.686 rs2991977 chr1:46053683 G/A cg06784218 chr1:46089804 CCDC17 -0.63 -11.69 -0.54 1.23e-26 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs11628318 0.853 rs10151896 chr14:103039936 G/C cg23071808 chr14:103021642 NA -0.68 -8.97 -0.44 2.38e-17 Platelet count; CRC cis rs6662572 1.000 rs41310432 chr1:46083706 C/G cg08644498 chr1:46502608 NA 0.45 6.51 0.34 2.81e-10 Blood protein levels; CRC cis rs7692995 1.000 rs7668933 chr4:17988141 A/G cg08925142 chr4:18023851 LCORL -0.53 -5.9 -0.31 8.82e-9 Height; CRC cis rs17092148 0.652 rs4911154 chr20:32996101 A/G cg08999081 chr20:33150536 PIGU 0.48 6.0 0.31 5.31e-9 Neuroticism; CRC cis rs2249694 0.959 rs4129223 chr10:135403948 A/G cg16964102 chr10:135390573 NA 0.43 7.22 0.37 3.72e-12 Obesity-related traits; CRC cis rs11098499 0.908 rs2017057 chr4:120257711 A/G cg09307838 chr4:120376055 NA 0.69 10.55 0.5 1.27e-22 Corneal astigmatism; CRC cis rs7552404 0.727 rs12122939 chr1:76276353 T/C cg10523679 chr1:76189770 ACADM 0.69 9.02 0.45 1.56e-17 Blood metabolite levels;Acylcarnitine levels; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg12159259 chr13:113642515 MCF2L -0.43 -7.02 -0.36 1.26e-11 Liver disease severity in Alagille syndrome; CRC cis rs6879260 1.000 rs7706951 chr5:179733407 C/T cg02891314 chr5:179741120 GFPT2 -0.66 -10.13 -0.49 3.56e-21 Height; CRC cis rs7917772 0.503 rs11191321 chr10:104293412 C/T cg22532475 chr10:104410764 TRIM8 -0.36 -6.62 -0.34 1.43e-10 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC cis rs3785574 0.927 rs2727313 chr17:61961914 A/G cg22520471 chr17:61851767 DDX42;CCDC47 0.46 6.29 0.33 9.92e-10 Height; CRC cis rs3864277 0.510 rs31478 chr5:131423475 T/C cg12564285 chr5:131593104 PDLIM4 0.33 5.82 0.31 1.4e-8 Itch intensity from mosquito bite adjusted by bite size; CRC cis rs4862750 1.000 rs4862751 chr4:187904050 G/A cg06074448 chr4:187884817 NA -0.61 -11.06 -0.52 2.12e-24 Lobe attachment (rater-scored or self-reported); CRC cis rs7224685 0.501 rs8066272 chr17:3900528 C/T cg09695851 chr17:3907499 NA 0.83 16.4 0.67 1.33e-44 Type 2 diabetes; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg26859392 chr3:10143019 FANCD2;C3orf24 0.43 6.92 0.36 2.34e-11 Liver disease severity in Alagille syndrome; CRC cis rs3820928 1.000 rs2396433 chr2:227772502 A/G cg11843606 chr2:227700838 RHBDD1 -0.41 -5.91 -0.31 8.42e-9 Pulmonary function; CRC cis rs2836974 0.568 rs7282604 chr21:40536910 C/T cg06238570 chr21:40685208 BRWD1 -0.78 -12.33 -0.56 5.47e-29 Cognitive function; CRC cis rs7666738 0.791 rs7678564 chr4:99057341 A/G cg05340658 chr4:99064831 C4orf37 0.6 9.3 0.46 2.03e-18 Colonoscopy-negative controls vs population controls; CRC cis rs4665809 0.878 rs35709953 chr2:26334997 G/A cg26119090 chr2:26468346 HADHA;HADHB 0.64 7.35 0.38 1.6e-12 Gut microbiome composition (summer); CRC trans rs6601327 0.551 rs13272424 chr8:9575319 T/G cg06636001 chr8:8085503 FLJ10661 -0.52 -7.49 -0.38 6.29e-13 Multiple myeloma (hyperdiploidy); CRC cis rs9486715 0.659 rs9399930 chr6:96854444 G/T cg18709589 chr6:96969512 KIAA0776 0.44 6.35 0.33 7.07e-10 Headache; CRC trans rs4689592 0.619 rs2359011 chr4:7066052 T/G cg07817883 chr1:32538562 TMEM39B -0.6 -7.53 -0.38 4.96e-13 Monocyte percentage of white cells; CRC cis rs7289126 1.000 rs7289126 chr22:38628306 A/C cg25457927 chr22:38595422 NA 0.3 6.1 0.32 3.03e-9 Mammographic density (dense area);Percent mammographic density; CRC trans rs17685 0.672 rs1639623 chr7:75707951 A/G cg19862616 chr7:65841803 NCRNA00174 0.99 18.51 0.71 6.2e-53 Coffee consumption;Coffee consumption (cups per day); CRC cis rs7208859 0.673 rs423151 chr17:28952286 A/G cg13385521 chr17:29058706 SUZ12P 0.48 6.44 0.33 4.17e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs1044826 0.597 rs1017468 chr3:139145778 A/G cg00490450 chr3:139108681 COPB2 0.46 6.96 0.36 1.89e-11 Obesity-related traits; CRC cis rs9303542 0.625 rs8066613 chr17:46583520 T/A cg04904318 chr17:46607828 HOXB1 -0.52 -6.27 -0.33 1.16e-9 Ovarian cancer;Epithelial ovarian cancer; CRC cis rs644799 0.965 rs11021317 chr11:95517576 C/T cg03916912 chr11:95522834 CEP57;FAM76B 0.96 18.02 0.7 5.41e-51 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs1552244 0.572 rs41464050 chr3:10158393 A/G cg13047869 chr3:10149882 C3orf24 0.52 6.39 0.33 5.61e-10 Alzheimer's disease; CRC cis rs6502050 0.835 rs8065037 chr17:80158966 T/G cg22110888 chr17:80059540 CCDC57 0.38 6.01 0.31 5.06e-9 Life satisfaction; CRC cis rs651907 0.557 rs56291106 chr3:101377474 C/T cg11279151 chr3:101281821 RG9MTD1 -0.57 -7.74 -0.39 1.25e-13 Colorectal cancer; CRC cis rs12541635 0.677 rs11781331 chr8:107066936 G/A cg10147462 chr8:107024639 NA -0.59 -10.3 -0.49 9.32e-22 Age of smoking initiation; CRC cis rs6582630 0.560 rs11504462 chr12:38440379 G/A cg13010199 chr12:38710504 ALG10B -0.4 -5.68 -0.3 3.02e-8 Drug-induced liver injury (flucloxacillin); CRC cis rs7726839 0.574 rs72705014 chr5:619815 C/G cg16447950 chr5:562315 NA -0.74 -9.73 -0.47 7.89e-20 Obesity-related traits; CRC cis rs10504229 0.871 rs10504227 chr8:58162005 G/A cg02725872 chr8:58115012 NA -0.47 -8.62 -0.43 2.86e-16 Developmental language disorder (linguistic errors); CRC cis rs1862618 0.671 rs2591965 chr5:56236176 T/C cg20203395 chr5:56204925 C5orf35 0.52 7.02 0.36 1.28e-11 Initial pursuit acceleration; CRC cis rs7552404 0.924 rs7535991 chr1:76162624 C/T cg22875332 chr1:76189707 ACADM 0.76 11.1 0.52 1.61e-24 Blood metabolite levels;Acylcarnitine levels; CRC trans rs208520 0.661 rs207079 chr6:66770462 C/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.06 -14.84 -0.63 1.75e-38 Exhaled nitric oxide output; CRC cis rs4713118 0.869 rs9283880 chr6:27715243 A/C cg26587870 chr6:27730563 NA -0.43 -6.69 -0.35 9.61e-11 Parkinson's disease; CRC cis rs8060686 0.858 rs2271294 chr16:67902326 A/T cg01951491 chr16:67709440 GFOD2 -0.44 -5.85 -0.31 1.17e-8 HDL cholesterol;Metabolic syndrome; CRC cis rs1008375 0.932 rs2302391 chr4:17660237 T/C cg16339924 chr4:17578868 LAP3 0.51 6.59 0.34 1.71e-10 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs6500602 0.673 rs1861652 chr16:4505331 C/T cg14951292 chr16:4525986 HMOX2;NMRAL1 0.58 8.46 0.42 9e-16 Schizophrenia; CRC cis rs6424115 1.000 rs34477640 chr1:24154067 T/C cg15997130 chr1:24165203 NA -0.75 -11.75 -0.54 7.27e-27 Immature fraction of reticulocytes; CRC cis rs875971 0.545 rs2420456 chr7:65745606 T/G cg05627663 chr7:65219948 SNORA22;CCT6P1 0.61 7.96 0.4 2.75e-14 Aortic root size; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg12871507 chr1:110163427 AMPD2 0.48 7.15 0.37 5.68e-12 Intelligence (multi-trait analysis); CRC cis rs4363385 0.818 rs1415969 chr1:153006448 G/T cg25856811 chr1:152973957 SPRR3 -0.25 -6.99 -0.36 1.51e-11 Inflammatory skin disease; CRC cis rs11758351 0.660 rs2143345 chr6:26229148 C/T cg08260959 chr6:26240920 HIST1H4F -0.36 -5.8 -0.3 1.55e-8 Gout;Renal underexcretion gout; CRC cis rs7647973 0.600 rs35174559 chr3:49287759 T/C cg07636037 chr3:49044803 WDR6 0.83 12.71 0.57 2.19e-30 Menarche (age at onset); CRC cis rs763121 0.853 rs4821812 chr22:39075235 G/C cg06544989 chr22:39130855 UNC84B 0.45 6.95 0.36 1.96e-11 Menopause (age at onset); CRC cis rs7587476 0.736 rs62202002 chr2:215690600 T/C cg04004882 chr2:215674386 BARD1 0.66 9.22 0.45 3.72e-18 Neuroblastoma; CRC cis rs6951245 1.000 rs11763793 chr7:1094342 A/G cg07217954 chr7:1067459 C7orf50 0.55 5.75 0.3 2.03e-8 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC trans rs11098499 0.754 rs714899 chr4:120243035 G/A cg25214090 chr10:38739885 LOC399744 0.53 8.32 0.42 2.33e-15 Corneal astigmatism; CRC cis rs7824557 0.583 rs2263512 chr8:11233419 T/G cg08071915 chr8:12219732 FAM66A 0.36 6.32 0.33 8.47e-10 Retinal vascular caliber; CRC cis rs514406 0.823 rs501006 chr1:53368292 T/A cg24675658 chr1:53192096 ZYG11B -0.58 -8.46 -0.42 8.86e-16 Monocyte count; CRC cis rs9910055 0.762 rs6503489 chr17:42246289 G/A cg13607699 chr17:42295918 UBTF 0.48 6.72 0.35 8.08e-11 Total body bone mineral density; CRC cis rs58688157 0.705 rs11539530 chr11:609353 G/A cg09218773 chr11:619014 MUPCDH -0.43 -6.28 -0.33 1.09e-9 Systemic lupus erythematosus; CRC cis rs7551222 0.749 rs4951409 chr1:204560990 A/T cg07972458 chr1:204535000 NA 0.36 5.61 0.3 4.21e-8 Schizophrenia; CRC cis rs853679 0.567 rs16894091 chr6:28390137 A/T cg21251018 chr6:28226885 NKAPL -0.39 -5.64 -0.3 3.7e-8 Depression; CRC cis rs4589502 1.000 rs16950284 chr15:67154184 A/G cg12317470 chr15:67143691 NA -0.72 -7.31 -0.37 2.05e-12 Lung cancer (smoking interaction); CRC cis rs7208859 0.573 rs73267872 chr17:29067207 T/C cg01831904 chr17:28903510 LRRC37B2 -0.62 -6.39 -0.33 5.8e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC trans rs7395662 0.929 rs11039903 chr11:48679705 G/T cg21153622 chr11:89784906 NA -0.49 -8.07 -0.41 1.32e-14 HDL cholesterol; CRC cis rs10504229 0.683 rs67035623 chr8:58139963 G/T cg04204079 chr8:58130323 NA -0.45 -5.78 -0.3 1.71e-8 Developmental language disorder (linguistic errors); CRC cis rs4731207 0.661 rs6466956 chr7:124520366 T/C cg23710748 chr7:124431027 NA -0.38 -6.08 -0.32 3.42e-9 Cutaneous malignant melanoma; CRC cis rs7666738 0.830 rs1426669 chr4:98945534 C/T cg05340658 chr4:99064831 C4orf37 0.61 9.53 0.47 3.55e-19 Colonoscopy-negative controls vs population controls; CRC cis rs735396 1.000 rs1169306 chr12:121438311 C/T cg02403541 chr12:121454288 C12orf43 0.44 6.59 0.34 1.7e-10 N-glycan levels; CRC cis rs7149337 1.000 rs35567150 chr14:51725944 A/G cg23942311 chr14:51606299 NA 0.64 11.03 0.52 2.86e-24 Cancer; CRC cis rs10504229 1.000 rs77823122 chr8:58170161 A/G cg24829409 chr8:58192753 C8orf71 -0.68 -11.34 -0.53 2.27e-25 Developmental language disorder (linguistic errors); CRC cis rs9486719 0.857 rs2971609 chr6:97039665 A/G cg06623918 chr6:96969491 KIAA0776 -0.84 -12.21 -0.56 1.56e-28 Migraine;Coronary artery disease; CRC cis rs9733 0.628 rs72700895 chr1:150626029 C/T cg10589385 chr1:150898437 SETDB1 0.28 5.98 0.31 5.86e-9 Tonsillectomy; CRC trans rs2303319 0.504 rs62189048 chr2:162613494 G/C cg10498984 chr16:28874827 SH2B1 -0.73 -6.3 -0.33 9.75e-10 Cognitive function; CRC cis rs9649213 0.593 rs1468340 chr7:97987676 T/G cg21770322 chr7:97807741 LMTK2 0.52 8.52 0.43 5.7e-16 Prostate cancer (SNP x SNP interaction); CRC cis rs9612 1.000 rs8105041 chr19:44258458 A/G cg08581076 chr19:44259116 C19orf61 0.48 6.24 0.33 1.35e-9 Exhaled nitric oxide output; CRC cis rs10791097 0.547 rs3829271 chr11:130753912 T/A cg12179176 chr11:130786555 SNX19 0.73 11.98 0.55 1.12e-27 Autism spectrum disorder or schizophrenia;Schizophrenia; CRC cis rs6952808 0.929 rs2280548 chr7:1976667 G/T cg02951883 chr7:2050386 MAD1L1 -0.7 -10.6 -0.5 8.82e-23 Bipolar disorder and schizophrenia; CRC cis rs11112613 0.762 rs66754070 chr12:105949779 G/A cg03607813 chr12:105948248 NA 0.8 10.66 0.51 5.65e-23 Corrected insulin response;Corrected insulin response adjusted for insulin sensitivity index; CRC cis rs11764590 0.715 rs55770986 chr7:2087823 T/C cg25834613 chr7:1915315 MAD1L1 -0.44 -6.35 -0.33 7.06e-10 Neuroticism; CRC cis rs11098499 0.954 rs10031665 chr4:120422852 T/C cg24375607 chr4:120327624 NA 0.48 7.36 0.38 1.5e-12 Corneal astigmatism; CRC cis rs9372498 0.505 rs9481811 chr6:118801174 T/C cg15382696 chr6:118971807 C6orf204 0.59 7.4 0.38 1.16e-12 Diastolic blood pressure; CRC cis rs2302190 0.882 rs8068135 chr17:56654210 A/C cg12560992 chr17:57184187 TRIM37 0.53 6.19 0.32 1.79e-9 Vitamin D levels; CRC cis rs3772130 0.775 rs6769102 chr3:121560722 G/A cg20356878 chr3:121714668 ILDR1 0.52 8.2 0.41 5.3e-15 Cognitive performance; CRC cis rs1153858 1.000 rs3809472 chr15:45694318 G/T cg21132104 chr15:45694354 SPATA5L1 0.63 8.94 0.44 2.92e-17 Homoarginine levels; CRC cis rs2204008 0.748 rs7312204 chr12:38334909 T/C cg13010199 chr12:38710504 ALG10B 0.47 6.53 0.34 2.47e-10 Bladder cancer; CRC trans rs875971 0.545 rs2420612 chr7:66001812 G/A cg02869306 chr7:64672164 INTS4L1 -0.45 -6.42 -0.33 4.84e-10 Aortic root size; CRC cis rs7615952 0.576 rs17523380 chr3:125802874 C/T cg15145296 chr3:125709740 NA -0.53 -6.89 -0.35 2.9e-11 Blood pressure (smoking interaction); CRC cis rs4631830 0.900 rs7914347 chr10:51537431 C/T cg20129853 chr10:51489980 NA -0.36 -5.92 -0.31 8.09e-9 Prostate-specific antigen levels; CRC trans rs9545047 0.716 rs9545053 chr13:79870214 T/G cg07061582 chr15:90234082 PEX11A;WDR93 0.42 5.98 0.31 5.82e-9 Schizophrenia; CRC cis rs9858542 0.953 rs9878943 chr3:49434654 G/A cg07274523 chr3:49395745 GPX1 0.45 6.06 0.32 3.67e-9 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg06598631 chr6:88300029 RARS2;ORC3L 0.47 6.06 0.32 3.8e-9 Thyroid stimulating hormone; CRC trans rs7395662 0.963 rs60772766 chr11:48721011 C/T cg21153622 chr11:89784906 NA -0.48 -7.79 -0.39 8.83e-14 HDL cholesterol; CRC cis rs1707322 1.000 rs785510 chr1:46528618 T/C cg03146154 chr1:46216737 IPP -0.58 -7.78 -0.39 9.14e-14 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC trans rs11105468 1.000 rs11105462 chr12:90311971 G/A cg23572944 chr11:60720130 SLC15A3 -0.43 -5.99 -0.31 5.37e-9 Febrile seizures;Febrile seizures (MMR vaccine-related);Febrile seizures (MMR vaccine-unrelated); CRC cis rs644799 1.000 rs500054 chr11:95593806 G/A cg03916912 chr11:95522834 CEP57;FAM76B 0.96 17.66 0.7 1.49e-49 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs853679 0.760 rs11962305 chr6:28199937 G/C cg25164649 chr6:28176230 NA 0.59 6.14 0.32 2.33e-9 Depression; CRC cis rs9326248 0.652 rs7128382 chr11:117023487 A/C cg26566898 chr11:117069891 TAGLN 0.39 6.97 0.36 1.76e-11 Blood protein levels; CRC cis rs9329289 1.000 rs9329289 chr10:2542389 A/G cg05625103 chr10:2543513 NA 0.39 6.22 0.32 1.54e-9 Age-related hearing impairment; CRC cis rs6496667 0.865 rs7183944 chr15:90889111 C/T cg04176472 chr15:90893244 GABARAPL3 0.63 7.14 0.37 5.9e-12 Rheumatoid arthritis; CRC cis rs1348850 0.918 rs12463893 chr2:178448559 G/T cg22681709 chr2:178499509 PDE11A -0.33 -6.23 -0.32 1.44e-9 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs1862618 0.853 rs33322 chr5:56175226 A/G cg20203395 chr5:56204925 C5orf35 -0.72 -8.29 -0.42 2.99e-15 Initial pursuit acceleration; CRC cis rs1552244 0.882 rs3732967 chr3:10015437 T/C cg16606324 chr3:10149918 C3orf24 0.61 7.98 0.4 2.47e-14 Alzheimer's disease; CRC cis rs35264875 0.808 rs2305498 chr11:68866914 G/A cg01993067 chr11:68851601 TPCN2 0.51 6.5 0.34 3.03e-10 Blond vs. brown hair color; CRC cis rs9527 0.590 rs12415388 chr10:104796345 T/C cg15744005 chr10:104629667 AS3MT -0.31 -6.28 -0.33 1.09e-9 Arsenic metabolism; CRC trans rs35110281 0.592 rs6417729 chr21:44967202 A/C cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.53 8.76 0.43 1.04e-16 Mean corpuscular volume; CRC cis rs75920871 0.588 rs1940626 chr11:116828121 T/C cg01368799 chr11:117014884 PAFAH1B2 -0.43 -6.01 -0.31 4.99e-9 Subjective well-being; CRC trans rs800082 0.516 rs7611932 chr3:144200593 A/G cg24215973 chr2:240111563 HDAC4 0.45 6.23 0.32 1.43e-9 Smoking behavior; CRC cis rs4938330 0.681 rs12271169 chr11:116980021 C/G cg01368799 chr11:117014884 PAFAH1B2 -0.45 -6.37 -0.33 6.3e-10 Blood protein levels; CRC cis rs1223397 0.651 rs202019 chr6:13301790 A/C cg07912922 chr6:13274314 PHACTR1 0.37 5.72 0.3 2.36e-8 Blood pressure; CRC cis rs13217239 0.511 rs3800314 chr6:27236048 T/G cg11262757 chr6:27280423 POM121L2 0.28 5.68 0.3 2.97e-8 Schizophrenia; CRC cis rs974417 0.530 rs11751305 chr6:97296833 G/A cg14723344 chr6:97285662 GPR63 0.42 6.02 0.32 4.6e-9 Body mass index; CRC cis rs929354 0.566 rs6979947 chr7:157005863 C/T cg05182265 chr7:156933206 UBE3C 0.69 12.05 0.55 6.21e-28 Body mass index; CRC cis rs13108904 0.901 rs6851528 chr4:1296009 G/A cg16405210 chr4:1374714 KIAA1530 -0.43 -6.19 -0.32 1.84e-9 Obesity-related traits; CRC cis rs208520 0.690 rs207740 chr6:66764132 T/G cg07460842 chr6:66804631 NA 1.06 14.72 0.63 5.16e-38 Exhaled nitric oxide output; CRC cis rs1799949 1.000 rs8176289 chr17:41206056 T/C cg23758822 chr17:41437982 NA 0.8 13.69 0.6 4.46e-34 Menopause (age at onset); CRC cis rs10791097 0.506 rs10750446 chr11:130706918 T/C cg12179176 chr11:130786555 SNX19 -0.43 -6.33 -0.33 8.11e-10 Autism spectrum disorder or schizophrenia;Schizophrenia; CRC trans rs10411161 1.000 rs8111316 chr19:52369069 A/C cg22319618 chr22:45562946 NUP50 -0.5 -5.97 -0.31 6.2e-9 Breast cancer; CRC trans rs6413860 0.637 rs12035469 chr1:246858531 A/G cg25623271 chr1:240656217 GREM2 -0.43 -6.2 -0.32 1.67e-9 Gut microbiome composition (summer); CRC cis rs9291683 0.530 rs73227883 chr4:9979279 T/C cg11266682 chr4:10021025 SLC2A9 0.5 10.04 0.48 7.51e-21 Bone mineral density; CRC cis rs243505 0.668 rs2072406 chr7:148483760 G/A cg09806900 chr7:148480153 CUL1 0.55 7.91 0.4 4.06e-14 Inflammatory bowel disease;Crohn's disease; CRC cis rs11098499 0.739 rs6534130 chr4:120131339 A/T cg09307838 chr4:120376055 NA -0.52 -8.13 -0.41 9.06e-15 Corneal astigmatism; CRC trans rs7580658 0.614 rs7585198 chr2:127962635 C/T cg06476606 chr10:91061728 IFIT2 -0.43 -5.98 -0.31 5.92e-9 Protein C levels; CRC cis rs9905704 0.671 rs28709536 chr17:57008912 C/A cg12560992 chr17:57184187 TRIM37 0.62 9.42 0.46 8.4e-19 Testicular germ cell tumor; CRC cis rs7605827 0.897 rs7590198 chr2:15536314 C/T cg19274914 chr2:15703543 NA 0.39 5.88 0.31 9.87e-9 Educational attainment (years of education); CRC cis rs7849270 0.921 rs7019373 chr9:131897221 C/T cg13538475 chr9:131942899 NA -0.32 -6.4 -0.33 5.3e-10 Blood metabolite ratios; CRC cis rs1499614 1.000 rs2707828 chr7:66171377 G/A cg18252515 chr7:66147081 NA -1.24 -14.6 -0.63 1.48e-37 Gout; CRC cis rs9487051 0.872 rs1111865 chr6:109610863 A/G cg12927641 chr6:109611667 NA 0.37 6.81 0.35 4.61e-11 Reticulocyte fraction of red cells; CRC trans rs17780086 0.527 rs72827711 chr17:30537920 T/A cg20587970 chr11:113659929 NA -1.37 -15.11 -0.64 1.47e-39 Height; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg07991241 chr10:33269695 NA 0.48 6.79 0.35 5.14e-11 Response to antipsychotic treatment; CRC cis rs8141529 0.748 rs1318026 chr22:29283518 A/G cg02153584 chr22:29168773 CCDC117 0.48 6.9 0.36 2.61e-11 Lymphocyte counts; CRC cis rs2303759 1.000 rs2303759 chr19:49869051 T/G cg22133161 chr19:49891603 CCDC155 0.52 7.29 0.37 2.36e-12 Multiple sclerosis; CRC cis rs7614311 0.681 rs73130565 chr3:63887135 T/C cg22134162 chr3:63841271 THOC7 -0.58 -5.87 -0.31 1.09e-8 Lung function (FVC);Lung function (FEV1); CRC cis rs9443645 0.901 rs9443622 chr6:79582790 C/T cg11833968 chr6:79620685 NA -0.36 -6.26 -0.33 1.23e-9 Intelligence (multi-trait analysis); CRC cis rs3126085 0.935 rs10888470 chr1:152200472 T/C cg09127314 chr1:152161683 NA 0.47 6.08 0.32 3.36e-9 Atopic dermatitis; CRC cis rs853679 0.517 rs9393884 chr6:28046789 A/G cg15786705 chr6:28176104 NA 0.71 9.12 0.45 7.73e-18 Depression; CRC cis rs7618915 0.524 rs35249778 chr3:52661640 G/C cg18404041 chr3:52824283 ITIH1 -0.43 -8.84 -0.44 5.81e-17 Bipolar disorder; CRC trans rs9650657 0.675 rs2409658 chr8:10668965 A/G cg06636001 chr8:8085503 FLJ10661 -0.43 -6.22 -0.32 1.54e-9 Neuroticism; CRC cis rs4824093 0.610 rs58671506 chr22:50288983 G/A cg22709217 chr22:50311962 ALG12;CRELD2 -0.97 -8.49 -0.42 7.01e-16 Amyotrophic lateral sclerosis (sporadic); CRC cis rs2204008 0.837 rs11172728 chr12:38070042 C/A cg26384229 chr12:38710491 ALG10B 0.67 9.3 0.46 2.04e-18 Bladder cancer; CRC cis rs853679 0.517 rs9468298 chr6:28122345 A/G cg23161317 chr6:28129485 ZNF389 0.53 6.43 0.33 4.52e-10 Depression; CRC cis rs7727544 0.904 rs58835386 chr5:131600559 A/G cg09877947 chr5:131593287 PDLIM4 0.35 6.57 0.34 1.96e-10 Blood metabolite levels; CRC cis rs4713118 0.512 rs2622319 chr6:28120401 G/C cg03623178 chr6:28175578 NA 0.8 11.74 0.54 8.21e-27 Parkinson's disease; CRC cis rs4819052 0.851 rs7275874 chr21:46671223 C/T cg11663144 chr21:46675770 NA -0.86 -15.13 -0.64 1.24e-39 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs9311676 0.656 rs11714807 chr3:58405431 A/G cg06643156 chr3:58380774 PXK 0.42 6.38 0.33 5.84e-10 Systemic lupus erythematosus; CRC cis rs9894429 0.608 rs7406382 chr17:79597786 T/C cg18240062 chr17:79603768 NPLOC4 0.49 7.68 0.39 1.83e-13 Eye color traits; CRC cis rs2839186 0.732 rs8131458 chr21:47694712 G/A cg20399509 chr21:47717575 C21orf57 -0.39 -6.48 -0.34 3.43e-10 Testicular germ cell tumor; CRC cis rs7647973 1.000 rs10155014 chr3:49432321 C/T cg07690219 chr3:49449608 TCTA;RHOA -0.52 -6.18 -0.32 1.9e-9 Menarche (age at onset); CRC cis rs12497850 0.805 rs11130176 chr3:48844077 A/G cg07636037 chr3:49044803 WDR6 1.04 18.72 0.72 9.87e-54 Parkinson's disease; CRC cis rs7613875 0.641 rs2624845 chr3:50062437 C/A cg24110177 chr3:50126178 RBM5 0.52 7.88 0.4 4.8e-14 Body mass index; CRC cis rs4731207 0.698 rs10954045 chr7:124498155 T/C cg23710748 chr7:124431027 NA -0.38 -6.08 -0.32 3.42e-9 Cutaneous malignant melanoma; CRC cis rs2688482 0.557 rs2550236 chr3:195522321 A/G cg12923728 chr3:195709715 SDHAP1 -0.59 -6.16 -0.32 2.1e-9 Lung disease severity in cystic fibrosis; CRC cis rs7107174 0.892 rs1567891 chr11:78101985 A/G cg02023728 chr11:77925099 USP35 0.47 7.25 0.37 2.92e-12 Testicular germ cell tumor; CRC cis rs514406 0.861 rs12038438 chr1:53230581 A/T cg25767906 chr1:53392781 SCP2 0.45 7.16 0.37 5.34e-12 Monocyte count; CRC cis rs6952808 0.609 rs10230383 chr7:1950113 T/C cg22963979 chr7:1858916 MAD1L1 -0.42 -6.68 -0.35 1.01e-10 Bipolar disorder and schizophrenia; CRC cis rs11212617 0.870 rs227063 chr11:108207304 T/G cg14761454 chr11:108092087 ATM;NPAT 0.44 6.59 0.34 1.77e-10 Response to metformin in type 2 diabetes (glycemic); CRC trans rs7618501 0.933 rs6809431 chr3:49804119 A/G cg21659725 chr3:3221576 CRBN 0.91 17.27 0.69 4.82e-48 Intelligence (multi-trait analysis); CRC cis rs17065868 0.764 rs73188730 chr13:45031377 C/T cg10246903 chr13:45222710 NA 0.56 5.92 0.31 8.25e-9 Antineutrophil cytoplasmic antibody-associated vasculitis; CRC cis rs889312 0.500 rs702691 chr5:56114526 T/G cg18230493 chr5:56204884 C5orf35 -0.41 -6.21 -0.32 1.58e-9 Breast cancer;Breast cancer (early onset); CRC cis rs9902453 0.967 rs6505155 chr17:28372783 A/T cg26525008 chr17:28256777 EFCAB5;SSH2 -0.59 -8.78 -0.44 8.99e-17 Coffee consumption (cups per day); CRC trans rs11039798 0.582 rs1304193 chr11:48688588 C/T cg03929089 chr4:120376271 NA 0.67 6.98 0.36 1.65e-11 Axial length; CRC cis rs7208859 0.623 rs2035494 chr17:29130393 T/G cg01831904 chr17:28903510 LRRC37B2 -0.62 -6.41 -0.33 5.13e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs4566357 0.615 rs10190621 chr2:227914484 A/G cg11843606 chr2:227700838 RHBDD1 -0.45 -6.88 -0.35 3.01e-11 Coronary artery disease; CRC cis rs2456568 0.835 rs7936182 chr11:93665532 T/A cg26875233 chr11:93583750 C11orf90 -0.33 -6.44 -0.33 4.28e-10 Response to serotonin reuptake inhibitors in major depressive disorder; CRC cis rs4919694 1.000 rs12241091 chr10:104808997 G/A cg04362960 chr10:104952993 NT5C2 1.11 10.44 0.5 3.09e-22 Arsenic metabolism; CRC cis rs6815814 0.861 rs7658651 chr4:38786002 A/C cg06935464 chr4:38784597 TLR10 0.7 9.09 0.45 9.48e-18 Breast cancer; CRC cis rs35264875 0.846 rs72930625 chr11:68867120 T/A cg01993067 chr11:68851601 TPCN2 0.53 5.93 0.31 7.58e-9 Blond vs. brown hair color; CRC cis rs2421770 0.504 rs4756213 chr11:35363566 T/C cg13971030 chr11:35366721 SLC1A2 -0.4 -6.83 -0.35 4.1e-11 Staphylococcus aureus nasal carriage (persistent); CRC cis rs7246657 0.943 rs3803895 chr19:37898669 A/G cg23950597 chr19:37808831 NA -0.49 -6.1 -0.32 2.9e-9 Coronary artery calcification; CRC cis rs7412746 0.658 rs7528773 chr1:150915875 G/A cg10589385 chr1:150898437 SETDB1 0.32 6.83 0.35 4.05e-11 Melanoma; CRC cis rs11229555 1.000 rs11229543 chr11:58370698 G/A cg15696309 chr11:58395628 NA -0.95 -13.36 -0.59 7.99e-33 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg03480535 chr4:87856849 AFF1 -0.53 -6.65 -0.34 1.23e-10 Diisocyanate-induced asthma; CRC cis rs10479542 0.766 rs7733389 chr5:178974997 C/T cg22764044 chr5:178986830 RUFY1 0.34 5.72 0.3 2.34e-8 Lung cancer; CRC trans rs9858542 0.903 rs17080528 chr3:49389842 C/T cg21665057 chr3:196295764 WDR53;FBXO45 -0.62 -8.35 -0.42 1.94e-15 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs1799949 0.931 rs34410138 chr17:41279770 A/G cg01879757 chr17:41196368 BRCA1 -0.43 -6.58 -0.34 1.91e-10 Menopause (age at onset); CRC trans rs2243480 1.000 rs160652 chr7:65538431 A/G cg10756647 chr7:56101905 PSPH 0.69 7.2 0.37 4.24e-12 Diabetic kidney disease; CRC cis rs58688157 0.705 rs12419720 chr11:598205 C/G cg09218773 chr11:619014 MUPCDH -0.44 -6.38 -0.33 5.9e-10 Systemic lupus erythematosus; CRC cis rs853679 1.000 rs1936365 chr6:28268452 C/G cg06470822 chr6:28175283 NA -0.67 -7.23 -0.37 3.46e-12 Depression; CRC cis rs877282 1.000 rs12775643 chr10:773242 G/A cg06581033 chr10:766294 NA -0.47 -5.71 -0.3 2.58e-8 Uric acid levels; CRC cis rs4332037 0.805 rs10278591 chr7:1921362 A/G cg24505167 chr7:1915268 MAD1L1 0.49 8.0 0.4 2.22e-14 Bipolar disorder; CRC cis rs2836974 0.568 rs452377 chr21:40537183 T/C cg11890956 chr21:40555474 PSMG1 0.93 16.72 0.68 7.64e-46 Cognitive function; CRC cis rs2439831 0.850 rs28590651 chr15:44113016 T/C cg15269541 chr15:43626905 ADAL -0.48 -5.88 -0.31 9.87e-9 Lung cancer in ever smokers; CRC cis rs6445525 0.905 rs7636143 chr3:65992411 C/T cg06109867 chr3:66002991 MAGI1 0.35 5.79 0.3 1.65e-8 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs10751667 0.600 rs10751672 chr11:948712 T/C cg06064525 chr11:970664 AP2A2 -0.33 -6.76 -0.35 6.29e-11 Alzheimer's disease (late onset); CRC cis rs2712184 0.652 rs13000985 chr2:217644361 T/G cg05032264 chr2:217675019 NA 0.33 5.73 0.3 2.29e-8 Glomerular filtration rate;Glomerular filtration rate in non diabetics (creatinine); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg14611757 chr11:1012211 AP2A2 -0.39 -6.53 -0.34 2.54e-10 Liver disease severity in Alagille syndrome; CRC cis rs1008375 1.000 rs1860596 chr4:17660082 C/T cg02297831 chr4:17616191 MED28 0.46 6.2 0.32 1.69e-9 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs3790645 0.958 rs2290589 chr1:26880288 C/T cg23229016 chr1:26872525 RPS6KA1 0.28 6.29 0.33 1e-9 Glucose homeostasis traits; CRC trans rs2303319 0.504 rs62188961 chr2:162495399 A/G cg12500891 chr11:57225987 NA -0.67 -6.03 -0.32 4.51e-9 Cognitive function; CRC cis rs2404602 0.647 rs7165053 chr15:76978918 A/G cg23625390 chr15:77176239 SCAPER -0.85 -14.1 -0.61 1.2e-35 Blood metabolite levels; CRC cis rs3771570 1.000 rs56222556 chr2:242364119 G/A cg21155796 chr2:242212141 HDLBP 0.65 6.98 0.36 1.67e-11 Prostate cancer; CRC cis rs798554 0.679 rs7807978 chr7:2814635 C/T cg19717773 chr7:2847554 GNA12 -0.43 -7.29 -0.37 2.28e-12 Height; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg26537410 chr10:74451932 CCDC109A 0.45 6.51 0.34 2.81e-10 Anxiety disorder; CRC cis rs62244186 0.715 rs13321717 chr3:44667455 C/A cg10263370 chr3:44754102 ZNF502 -0.39 -6.51 -0.34 2.87e-10 Depressive symptoms; CRC cis rs1941023 0.503 rs4939349 chr11:60135880 G/A cg08716584 chr11:60157161 MS4A7 -0.53 -8.79 -0.44 8.32e-17 Congenital heart disease (maternal effect); CRC trans rs61931739 0.534 rs10844729 chr12:34022919 A/G cg26384229 chr12:38710491 ALG10B 0.51 6.67 0.35 1.1e-10 Morning vs. evening chronotype; CRC cis rs4588572 0.688 rs1594055 chr5:77695088 G/A cg11446398 chr5:77624930 NA 0.43 6.39 0.33 5.54e-10 Triglycerides; CRC cis rs2281845 0.507 rs10800760 chr1:201100439 G/A cg24849736 chr1:201084428 NA 0.46 6.05 0.32 3.87e-9 Permanent tooth development; CRC cis rs9303401 0.614 rs12950028 chr17:56510140 A/G cg02118635 chr17:56770003 RAD51C;TEX14 0.75 9.39 0.46 9.95e-19 Cognitive test performance; CRC cis rs7615952 0.512 rs4679430 chr3:125357893 T/C cg11143507 chr3:125485238 NA -0.58 -7.46 -0.38 7.69e-13 Blood pressure (smoking interaction); CRC trans rs2303319 0.504 rs55925603 chr2:162497210 G/A cg06896663 chr8:82754093 SNX16 -0.68 -6.1 -0.32 3.01e-9 Cognitive function; CRC cis rs4836694 0.517 rs1017112 chr9:132936804 A/G cg05251000 chr9:132935664 FREQ 0.51 7.8 0.4 8.07e-14 Alzheimer's disease (cognitive decline); CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg27301331 chr6:20401917 E2F3 0.48 6.08 0.32 3.27e-9 Thyroid stimulating hormone; CRC cis rs561341 0.629 rs7216107 chr17:30224419 G/A cg12193833 chr17:30244370 NA -0.39 -5.85 -0.31 1.17e-8 Hip circumference adjusted for BMI; CRC cis rs4654899 1.000 rs7522722 chr1:21481840 G/A cg02927042 chr1:21476669 EIF4G3 -0.48 -7.58 -0.39 3.62e-13 Superior frontal gyrus grey matter volume; CRC cis rs10256972 0.567 rs2960835 chr7:1202963 A/G cg18402987 chr7:1209562 NA 0.56 8.51 0.42 6.23e-16 Longevity;Endometriosis; CRC cis rs2230307 0.536 rs526128 chr1:100473427 T/A cg24955406 chr1:100503596 HIAT1 0.59 7.13 0.37 6.35e-12 Carotid intima media thickness; CRC cis rs6502050 0.871 rs62079994 chr17:80076516 T/C cg09264619 chr17:80180166 NA 0.36 5.92 0.31 8.22e-9 Life satisfaction; CRC cis rs57221529 0.600 rs11750269 chr5:666270 G/A cg16447950 chr5:562315 NA -0.84 -10.48 -0.5 2.32e-22 Lung disease severity in cystic fibrosis; CRC cis rs6951245 1.000 rs28399710 chr7:1070631 G/T cg24642844 chr7:1081250 C7orf50 -0.78 -9.35 -0.46 1.42e-18 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs6752107 0.936 rs6431660 chr2:234167234 A/G cg07618928 chr2:234183455 ATG16L1;SCARNA5 0.65 11.09 0.52 1.72e-24 Crohn's disease;Inflammatory bowel disease; CRC cis rs6860806 0.603 rs112300250 chr5:131583292 G/A cg18301423 chr5:131593218 PDLIM4 0.38 7.03 0.36 1.2e-11 Breast cancer; CRC trans rs61931739 0.534 rs1387789 chr12:34056304 C/A cg26384229 chr12:38710491 ALG10B 0.51 6.97 0.36 1.77e-11 Morning vs. evening chronotype; CRC cis rs13118159 0.801 rs7664474 chr4:1329116 T/A cg23123621 chr4:1343375 KIAA1530 0.37 6.4 0.33 5.28e-10 Longevity; CRC cis rs2731664 0.792 rs335467 chr5:176890642 A/G cg23176889 chr5:176863531 GRK6 -0.71 -14.79 -0.63 2.64e-38 Intelligence (multi-trait analysis); CRC trans rs9858542 0.903 rs17080528 chr3:49389842 C/T cg21659725 chr3:3221576 CRBN -0.65 -8.86 -0.44 4.98e-17 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs1862618 0.671 rs2591958 chr5:56239369 C/G cg12311346 chr5:56204834 C5orf35 0.64 9.67 0.47 1.25e-19 Initial pursuit acceleration; CRC cis rs7274811 0.901 rs55990870 chr20:32302908 C/T cg14921437 chr20:32255988 NECAB3;C20orf134 -0.49 -6.35 -0.33 7.19e-10 Height; CRC cis rs995000 0.931 rs12074528 chr1:63010871 T/C cg19896129 chr1:63156450 NA -0.44 -6.82 -0.35 4.3e-11 Triglyceride levels; CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg27006547 chr11:62606509 WDR74 -0.5 -6.49 -0.34 3.12e-10 Diisocyanate-induced asthma; CRC cis rs274567 0.501 rs581968 chr5:131710202 G/A cg09877947 chr5:131593287 PDLIM4 -0.44 -7.11 -0.37 7.08e-12 Blood metabolite levels; CRC cis rs6951245 0.554 rs11761322 chr7:1151657 A/G cg24642844 chr7:1081250 C7orf50 -0.47 -6.15 -0.32 2.21e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs2032447 0.901 rs1540276 chr6:26028819 T/G cg03264133 chr6:25882463 NA -0.5 -6.78 -0.35 5.54e-11 Intelligence (multi-trait analysis); CRC trans rs783540 0.632 rs17356528 chr15:83305550 A/G cg18393722 chr15:85113863 UBE2QP1 -0.41 -6.39 -0.33 5.55e-10 Schizophrenia; CRC cis rs897984 0.806 rs12924903 chr16:30928970 C/T cg02466173 chr16:30829666 NA -0.59 -8.94 -0.44 2.89e-17 Dementia with Lewy bodies; CRC cis rs4664293 0.605 rs6741498 chr2:160554622 G/A cg08347373 chr2:160653686 CD302 0.39 6.53 0.34 2.44e-10 Monocyte percentage of white cells; CRC cis rs1843834 0.898 rs2015099 chr2:225519915 T/C cg22455342 chr2:225449267 CUL3 0.44 6.02 0.31 4.66e-9 IgE levels in asthmatics (D.p. specific); CRC cis rs7726839 0.540 rs72703095 chr5:601789 T/C cg14541582 chr5:601475 NA -0.36 -7.32 -0.37 1.97e-12 Obesity-related traits; CRC cis rs6951245 0.938 rs112425403 chr7:1071531 A/G cg21664854 chr7:1097933 C7orf50;GPR146 0.78 8.86 0.44 4.99e-17 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC trans rs61931739 0.500 rs7137392 chr12:34447074 T/C cg26384229 chr12:38710491 ALG10B 0.62 9.11 0.45 8.27e-18 Morning vs. evening chronotype; CRC cis rs7212590 0.655 rs8072050 chr17:58010972 G/A cg10252138 chr17:58120427 NA -0.58 -6.28 -0.33 1.1e-9 Granulocyte percentage of myeloid white cells;Monocyte count;Monocyte percentage of white cells; CRC cis rs7677751 0.806 rs7673853 chr4:55096606 T/C cg00691999 chr4:55094011 PDGFRA 0.43 6.28 0.33 1.06e-9 Corneal astigmatism; CRC cis rs2153535 0.580 rs1115078 chr6:8449638 G/A cg07606381 chr6:8435919 SLC35B3 0.68 10.85 0.51 1.22e-23 Motion sickness; CRC cis rs1552244 1.000 rs7619340 chr3:10108178 C/T cg18598329 chr3:10140678 FANCD2;C3orf24 -0.86 -11.36 -0.53 1.9e-25 Alzheimer's disease; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg08167047 chr11:72463418 ARAP1 0.44 6.15 0.32 2.25e-9 Anxiety disorder; CRC cis rs1552244 0.882 rs2030564 chr3:10039044 A/G cg02579736 chr3:10068473 FANCD2;CIDECP 0.93 12.03 0.55 6.96e-28 Alzheimer's disease; CRC cis rs4925386 0.802 rs6142735 chr20:60918087 G/C cg24112000 chr20:60950667 NA -0.53 -8.24 -0.41 4.02e-15 Colorectal cancer;Colorectal cancer (SNP x SNP interaction); CRC cis rs10504229 0.906 rs59336968 chr8:58176857 T/C cg24829409 chr8:58192753 C8orf71 -0.68 -11.34 -0.53 2.27e-25 Developmental language disorder (linguistic errors); CRC cis rs6582630 0.502 rs11614397 chr12:38328163 C/T cg13010199 chr12:38710504 ALG10B 0.45 6.01 0.31 5.04e-9 Drug-induced liver injury (flucloxacillin); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg06916729 chr5:90676249 LOC100129716;ARRDC3 0.48 6.64 0.34 1.3100000000000001e-10 Response to antipsychotic treatment; CRC cis rs7617480 0.648 rs9848268 chr3:48762271 C/T cg20833759 chr3:49053208 WDR6;DALRD3 0.73 10.56 0.5 1.21e-22 Subjective well-being (multi-trait analysis);Menarche (age at onset); CRC cis rs11958404 0.932 rs72816541 chr5:157414686 G/A cg05962755 chr5:157440814 NA 0.77 10.62 0.51 7.79e-23 IgG glycosylation; CRC cis rs2075371 0.611 rs12531769 chr7:134016899 C/G cg20476274 chr7:133979776 SLC35B4 0.53 7.73 0.39 1.36e-13 Mean platelet volume; CRC cis rs12995491 0.731 rs13019346 chr2:88509321 A/G cg07952391 chr2:88470173 THNSL2 -0.41 -6.11 -0.32 2.75e-9 Response to metformin (IC50); CRC cis rs868036 0.958 rs12593813 chr15:68036852 C/T cg05925327 chr15:68127851 NA -0.3 -5.79 -0.3 1.65e-8 Restless legs syndrome; CRC trans rs2727020 0.637 rs1164673 chr11:49328356 C/G cg15704280 chr7:45808275 SEPT13 0.71 10.79 0.51 1.87e-23 Coronary artery disease; CRC cis rs1143633 0.615 rs4364030 chr2:113664409 C/G cg06156847 chr2:113672199 IL1F7 0.46 7.06 0.36 1e-11 Allergic disease (asthma, hay fever or eczema); CRC cis rs9467773 0.587 rs12214031 chr6:26376628 T/C cg14345882 chr6:26364793 BTN3A2 0.4 6.25 0.33 1.26e-9 Intelligence (multi-trait analysis); CRC cis rs57590327 0.503 rs2049415 chr3:81901887 A/T cg07356753 chr3:81810745 GBE1 -0.63 -8.54 -0.43 5.14e-16 Extraversion; CRC cis rs10504229 0.773 rs1874373 chr8:58194423 T/C cg05313129 chr8:58192883 C8orf71 -0.47 -7.16 -0.37 5.2e-12 Developmental language disorder (linguistic errors); CRC cis rs787274 0.543 rs4978509 chr9:115635641 C/G cg13803584 chr9:115635662 SNX30 -0.68 -7.15 -0.37 5.55e-12 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs3540 0.960 rs6496675 chr15:90982756 C/T cg22089800 chr15:90895588 ZNF774 0.51 8.12 0.41 9.6e-15 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; CRC cis rs6840360 1.000 rs4696111 chr4:152671405 T/C cg09659197 chr4:152720779 NA 0.53 11.67 0.54 1.47e-26 Intelligence (multi-trait analysis); CRC cis rs4332037 0.851 rs28728306 chr7:1961814 C/A cg25834613 chr7:1915315 MAD1L1 -0.44 -6.41 -0.33 4.92e-10 Bipolar disorder; CRC cis rs4969178 1.000 rs7212201 chr17:76393896 C/A cg20026190 chr17:76395443 PGS1 0.4 6.19 0.32 1.78e-9 HDL cholesterol levels; CRC cis rs7927771 0.864 rs55927797 chr11:47446292 A/T cg18512352 chr11:47633146 NA -0.4 -7.77 -0.39 9.9e-14 Subjective well-being; CRC cis rs6502050 0.799 rs6502078 chr17:80124364 G/A cg22110888 chr17:80059540 CCDC57 0.4 6.38 0.33 5.96e-10 Life satisfaction; CRC cis rs9309473 0.607 rs7574291 chr2:73594941 A/G cg20560298 chr2:73613845 ALMS1 -0.48 -6.74 -0.35 7.24e-11 Metabolite levels; CRC cis rs9368481 0.761 rs9379952 chr6:26987900 A/T cg06675483 chr6:26987649 LOC100270746;C6orf41 -0.41 -5.74 -0.3 2.15e-8 Autism spectrum disorder or schizophrenia; CRC cis rs1129187 0.967 rs9462857 chr6:42943098 T/C cg27588902 chr6:42928151 GNMT -0.38 -6.85 -0.35 3.61e-11 Alzheimer's disease in APOE e4+ carriers; CRC cis rs4722166 0.508 rs1474347 chr7:22768124 A/C cg26061582 chr7:22766209 IL6 -0.48 -7.46 -0.38 7.67e-13 Lung cancer; CRC cis rs4819052 0.851 rs10470247 chr21:46659018 T/C cg02159808 chr21:46707872 POFUT2;LOC642852 0.49 6.44 0.33 4.36e-10 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs8005677 1.000 rs1043209 chr14:23373986 A/G cg01529538 chr14:23388837 RBM23 -0.39 -6.27 -0.33 1.11e-9 Cognitive ability (multi-trait analysis); CRC cis rs13161895 1.000 rs6873994 chr5:179436696 T/G cg02702477 chr5:179499311 RNF130 -0.56 -6.48 -0.34 3.35e-10 LDL cholesterol; CRC cis rs3617 0.625 rs2071042 chr3:52864584 A/G cg07507251 chr3:52567010 NT5DC2 0.4 6.2 0.32 1.71e-9 Red blood cell count;Autism spectrum disorder or schizophrenia; CRC cis rs1881396 0.947 rs10173720 chr2:27855397 A/T cg27432699 chr2:27873401 GPN1 -0.62 -8.09 -0.41 1.2e-14 Nonalcoholic fatty liver disease; CRC cis rs13191362 0.507 rs2846536 chr6:163033492 A/G cg06582575 chr6:163149167 PACRG;PARK2 0.54 8.38 0.42 1.52e-15 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs9486715 1.000 rs9398148 chr6:97063555 A/G cg18709589 chr6:96969512 KIAA0776 -0.53 -7.64 -0.39 2.45e-13 Headache; CRC cis rs2836950 0.520 rs8130240 chr21:40538108 G/A cg11890956 chr21:40555474 PSMG1 -0.69 -10.51 -0.5 1.82e-22 Menarche (age at onset); CRC cis rs55882075 0.535 rs67484565 chr5:179110574 G/T cg14593053 chr5:179126677 CANX 0.47 6.95 0.36 1.92e-11 Monocyte percentage of white cells; CRC cis rs10504229 0.638 rs6981055 chr8:58113941 T/C cg21724239 chr8:58056113 NA 0.49 6.77 0.35 5.94e-11 Developmental language disorder (linguistic errors); CRC cis rs3733346 0.505 rs11734449 chr4:921733 C/A cg08222618 chr4:941054 TMEM175 0.74 12.83 0.58 7.98e-31 Sjögren's syndrome; CRC cis rs875971 0.895 rs6460300 chr7:65952924 A/G cg11764359 chr7:65958608 NA 0.63 10.13 0.49 3.71e-21 Aortic root size; CRC cis rs17666538 0.585 rs1703927 chr8:613620 A/G cg07234876 chr8:600039 NA -0.73 -6.95 -0.36 1.93e-11 IgG glycosylation; CRC cis rs875971 0.666 rs13242072 chr7:65765988 A/G cg18876405 chr7:65276391 NA -0.6 -10.53 -0.5 1.54e-22 Aortic root size; CRC cis rs9875589 0.957 rs6778731 chr3:13947504 T/C cg19554555 chr3:13937349 NA 0.44 6.39 0.33 5.7e-10 Ovarian reserve; CRC cis rs1865760 0.865 rs9467648 chr6:25957933 T/A cg17691542 chr6:26056736 HIST1H1C 0.55 8.4 0.42 1.36e-15 Height; CRC cis rs875971 0.862 rs6959268 chr7:65812966 G/A cg12463550 chr7:65579703 CRCP -0.53 -7.51 -0.38 5.45e-13 Aortic root size; CRC cis rs7917772 0.582 rs4917976 chr10:104360518 A/G cg11453585 chr10:104263688 ACTR1A;SUFU -0.83 -15.58 -0.65 2.29e-41 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC cis rs9467160 0.871 rs9461015 chr6:24449020 C/G cg20631270 chr6:24437470 GPLD1 -0.5 -7.01 -0.36 1.35e-11 Liver enzyme levels; CRC cis rs12580194 1.000 rs61539173 chr12:55703206 C/T cg19537932 chr12:55886519 OR6C68 -0.58 -8.07 -0.41 1.33e-14 Cancer; CRC cis rs769267 0.931 rs2965197 chr19:19470910 C/T cg02546618 chr19:19431379 KIAA0892;SF4 -0.47 -6.46 -0.34 3.86e-10 Tonsillectomy; CRC trans rs11722228 0.522 rs73212817 chr4:10064011 T/C cg26043149 chr18:55253948 FECH 1.13 17.17 0.69 1.3e-47 Gout;Urate levels;Serum uric acid levels; CRC cis rs954108 0.584 rs9314922 chr13:29379229 A/G cg05095123 chr13:29393749 NA 0.34 6.11 0.32 2.82e-9 Obesity-related traits; CRC cis rs929596 0.561 rs7564935 chr2:234645186 G/T cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.63 -9.3 -0.46 2.01e-18 Total bilirubin levels in HIV-1 infection; CRC cis rs826838 1.000 rs10880914 chr12:38720543 C/T cg13010199 chr12:38710504 ALG10B 0.48 6.33 0.33 8.17e-10 Heart rate; CRC cis rs1153858 1.000 rs12595087 chr15:45655232 A/G cg14582100 chr15:45693742 SPATA5L1 0.29 6.1 0.32 2.99e-9 Homoarginine levels; CRC cis rs10504229 0.683 rs17194487 chr8:58104912 C/T cg20607798 chr8:58055168 NA 0.58 6.78 0.35 5.52e-11 Developmental language disorder (linguistic errors); CRC cis rs1712517 0.904 rs4918007 chr10:105107470 G/A cg05636881 chr10:105038444 INA -0.44 -7.55 -0.38 4.25e-13 Migraine; CRC cis rs10504229 0.906 rs113745779 chr8:58191301 C/G cg01721255 chr8:58191610 C8orf71 0.49 6.17 0.32 2e-9 Developmental language disorder (linguistic errors); CRC trans rs4263408 0.934 rs9683743 chr4:39703194 A/C cg26979339 chr12:107168153 RIC8B -0.41 -6.39 -0.33 5.76e-10 Plasma amyloid beta peptide concentrations (ABx-40); CRC cis rs2204008 0.837 rs11183232 chr12:37941053 A/G cg26384229 chr12:38710491 ALG10B 0.65 9.04 0.45 1.42e-17 Bladder cancer; CRC trans rs11039798 0.588 rs6485857 chr11:48556511 C/A cg15704280 chr7:45808275 SEPT13 0.66 6.79 0.35 5.21e-11 Axial length; CRC cis rs7937682 0.814 rs1619652 chr11:111469757 G/A cg09085632 chr11:111637200 PPP2R1B -0.94 -17.4 -0.69 1.57e-48 Primary sclerosing cholangitis; CRC cis rs60843830 0.661 rs11674325 chr2:105517 C/T cg25945732 chr2:264204 ACP1;SH3YL1 0.46 6.38 0.33 6.18e-10 Spherical equivalent (joint analysis main effects and education interaction); CRC cis rs2084637 1.000 rs2084637 chr11:122391187 T/C cg21585512 chr11:122030076 LOC399959 -0.38 -6.65 -0.34 1.21e-10 Stroke; CRC cis rs9611565 0.649 rs126092 chr22:42178441 A/G cg03806693 chr22:41940476 POLR3H 0.7 9.25 0.45 3.03e-18 Vitiligo; CRC cis rs875971 1.000 rs1144895 chr7:65541307 C/G cg11764359 chr7:65958608 NA -0.6 -9.5 -0.46 4.46e-19 Aortic root size; CRC cis rs798554 0.686 rs7777484 chr7:2814271 A/G cg13628971 chr7:2884303 GNA12 0.41 6.08 0.32 3.35e-9 Height; CRC cis rs10504229 1.000 rs67384205 chr8:58180348 C/G cg01721255 chr8:58191610 C8orf71 0.49 6.17 0.32 2e-9 Developmental language disorder (linguistic errors); CRC cis rs4925386 0.625 rs3810550 chr20:60912117 C/T cg24112000 chr20:60950667 NA -0.47 -6.15 -0.32 2.29e-9 Colorectal cancer;Colorectal cancer (SNP x SNP interaction); CRC cis rs79518236 1 rs79518236 chr7:98026554 ACT/A cg09267113 chr7:98030324 BAIAP2L1 -0.94 -12.38 -0.56 3.69e-29 Breast cancer; CRC cis rs7177699 0.581 rs7181432 chr15:79123779 C/T cg15571903 chr15:79123663 NA 0.34 6.92 0.36 2.4e-11 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; CRC cis rs875971 0.660 rs62465434 chr7:66005152 A/C cg18876405 chr7:65276391 NA 0.61 10.95 0.52 5.42e-24 Aortic root size; CRC cis rs919433 0.662 rs2043018 chr2:198236958 G/A cg03934865 chr2:198174659 NA 0.36 5.82 0.31 1.42e-8 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC cis rs2204008 0.837 rs55962152 chr12:38234281 G/A cg26384229 chr12:38710491 ALG10B 0.68 9.08 0.45 9.92e-18 Bladder cancer; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg14347670 chr6:41908995 CCND3 0.49 6.39 0.33 5.83e-10 Thyroid stimulating hormone; CRC cis rs453301 0.686 rs6987107 chr8:8893581 A/G cg14979609 chr8:8086686 FLJ10661 0.38 6.23 0.32 1.42e-9 Joint mobility (Beighton score); CRC cis rs10752881 1.000 rs6701400 chr1:182977197 C/T ch.1.3577855R chr1:183094577 LAMC1 0.87 15.17 0.64 8.98e-40 Colorectal cancer; CRC cis rs9486715 0.867 rs12207471 chr6:96963782 A/G cg18709589 chr6:96969512 KIAA0776 0.49 7.2 0.37 4.01e-12 Headache; CRC cis rs2836974 0.897 rs35123057 chr21:40711689 C/T cg06238570 chr21:40685208 BRWD1 0.7 9.28 0.46 2.28e-18 Cognitive function; CRC cis rs17401966 1.000 rs12734551 chr1:10391536 A/C cg19773385 chr1:10388646 KIF1B -0.58 -7.95 -0.4 2.92e-14 Hepatocellular carcinoma; CRC trans rs16846053 0.786 rs72873645 chr2:162495047 G/A cg22988483 chr14:93581567 ITPK1 -0.66 -6.08 -0.32 3.27e-9 Blood osmolality (transformed sodium); CRC trans rs10982213 0.830 rs2274163 chr9:117188714 C/T cg23023044 chr1:110765955 KCNC4 -0.4 -6.44 -0.33 4.13e-10 Interleukin-6 levels; CRC cis rs2836950 0.545 rs1888489 chr21:40533164 T/C cg11644478 chr21:40555479 PSMG1 -0.45 -6.73 -0.35 7.4e-11 Menarche (age at onset); CRC cis rs2739330 0.789 rs5760109 chr22:24252938 C/G cg23131131 chr22:24373011 LOC391322 -0.64 -9.87 -0.48 2.76e-20 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs1552244 0.572 rs67227131 chr3:10172744 G/A cg08888203 chr3:10149979 C3orf24 0.7 7.55 0.38 4.22e-13 Alzheimer's disease; CRC cis rs10504229 0.817 rs35207430 chr8:58167614 G/A cg22535103 chr8:58192502 C8orf71 -0.76 -11.62 -0.54 2.13e-26 Developmental language disorder (linguistic errors); CRC cis rs4629710 0.563 rs9483238 chr6:131567196 A/T cg12606694 chr6:131520996 AKAP7 0.55 8.23 0.41 4.36e-15 Multiple myeloma (IgH translocation); CRC trans rs6951245 1.000 rs79443843 chr7:1075245 G/A cg13565492 chr6:43139072 SRF -0.71 -7.38 -0.38 1.34e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs10791323 0.546 rs55801927 chr11:133713094 A/C cg06766960 chr11:133703094 NA -0.35 -5.87 -0.31 1.06e-8 Childhood ear infection; CRC cis rs7586879 0.964 rs11688665 chr2:25121168 G/T cg22495460 chr2:25135724 ADCY3 -0.73 -12.05 -0.55 6.08e-28 Body mass index; CRC trans rs1814175 0.645 rs1851845 chr11:49982396 C/T cg15704280 chr7:45808275 SEPT13 -0.94 -16.88 -0.68 1.75e-46 Height; CRC trans rs3960554 0.808 rs78340819 chr7:75673833 C/G cg19862616 chr7:65841803 NCRNA00174 0.71 8.44 0.42 1.03e-15 Eotaxin levels; CRC cis rs67981189 0.529 rs61990379 chr14:71467070 A/G cg15910301 chr14:71632612 NA 0.31 6.11 0.32 2.89e-9 Schizophrenia; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg11301416 chr6:37225561 TMEM217;TBC1D22B 0.45 6.49 0.34 3.15e-10 Intelligence (multi-trait analysis); CRC cis rs4466137 0.953 rs7735476 chr5:83015140 G/C cg16102102 chr5:83017553 HAPLN1 -0.55 -7.85 -0.4 6.02e-14 Prostate cancer; CRC cis rs992157 0.835 rs6707559 chr2:219142773 C/T cg04880052 chr2:219191631 PNKD 0.41 6.61 0.34 1.53e-10 Colorectal cancer; CRC trans rs7267979 1.000 rs2259926 chr20:25281733 T/C cg17903999 chr18:56338584 MALT1 -0.42 -6.99 -0.36 1.52e-11 Liver enzyme levels (alkaline phosphatase); CRC cis rs7617773 0.779 rs11718329 chr3:48309828 C/G cg11946769 chr3:48343235 NME6 0.63 8.77 0.44 1e-16 Coronary artery disease; CRC trans rs3858526 0.874 rs10838879 chr11:5950169 C/T cg01505111 chr6:125621795 HDDC2 0.38 6.04 0.32 4.06e-9 DNA methylation (variation); CRC cis rs651907 0.557 rs2303474 chr3:101371899 G/T cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.62 8.16 0.41 7.25e-15 Colorectal cancer; CRC cis rs10256972 0.577 rs4999286 chr7:1199506 C/G cg26608667 chr7:1196370 ZFAND2A 0.43 6.89 0.36 2.78e-11 Longevity;Endometriosis; CRC cis rs6456156 0.904 rs2021033 chr6:167524239 C/T cg19688584 chr6:167529678 CCR6 -0.33 -5.74 -0.3 2.14e-8 Primary biliary cholangitis; CRC cis rs728616 0.614 rs1538818 chr10:82122793 G/A cg11900509 chr10:81946545 ANXA11 -0.56 -6.3 -0.33 9.41e-10 Chronic obstructive pulmonary disease-related biomarkers; CRC trans rs925098 0.577 rs2724470 chr4:17996046 A/G cg03519263 chr14:21152327 RNASE4;ANG -0.42 -6.07 -0.32 3.61e-9 Birth weight;Height; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg18168982 chr10:70661333 DDX50 0.41 6.06 0.32 3.72e-9 Intelligence (multi-trait analysis); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg13237843 chr11:6640720 TPP1 0.44 6.45 0.34 3.89e-10 Intelligence (multi-trait analysis); CRC cis rs7224685 0.501 rs781827 chr17:3962965 G/A cg05562828 chr17:3906858 NA 0.66 12.35 0.56 4.58e-29 Type 2 diabetes; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg04623168 chr12:112546260 NAA25 0.45 6.12 0.32 2.6e-9 Response to antipsychotic treatment; CRC cis rs5750830 0.649 rs5757663 chr22:39821319 T/C cg05872129 chr22:39784769 NA -0.57 -10.11 -0.49 4.16e-21 Intelligence (multi-trait analysis); CRC cis rs9811920 0.609 rs6765027 chr3:99687730 A/G cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G -0.46 -6.19 -0.32 1.78e-9 Axial length; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg17103702 chr17:73901075 MRPL38 0.43 6.16 0.32 2.13e-9 Anxiety disorder; CRC cis rs17711722 0.701 rs4467826 chr7:65368708 A/G cg18912574 chr7:65842487 NCRNA00174 0.33 5.66 0.3 3.22e-8 Calcium levels; CRC cis rs172166 0.637 rs1071893 chr6:28167635 G/C cg26587870 chr6:27730563 NA -0.36 -5.62 -0.3 4.14e-8 Cardiac Troponin-T levels; CRC trans rs12478296 0.901 rs7603560 chr2:243043256 C/T cg18288967 chr1:45987694 PRDX1 0.65 6.92 0.36 2.34e-11 Obesity-related traits; CRC cis rs6499255 0.904 rs12447883 chr16:69722797 T/C cg15192750 chr16:69999425 NA 0.62 8.26 0.41 3.63e-15 IgE levels; CRC cis rs881375 0.900 rs1008383 chr9:123683579 C/G cg09586646 chr9:123605570 PSMD5;LOC253039 0.51 7.02 0.36 1.29e-11 Rheumatoid arthritis; CRC cis rs847577 0.748 rs940432 chr7:97716483 G/A cg24562669 chr7:97807699 LMTK2 0.76 16.49 0.67 5.94e-45 Breast cancer; CRC cis rs10484885 0.553 rs12661697 chr6:90284329 T/G cg13799429 chr6:90582589 CASP8AP2 -0.58 -6.49 -0.34 3.07e-10 QRS interval (sulfonylurea treatment interaction); CRC cis rs989128 0.600 rs73338243 chr17:48631324 T/C cg16068336 chr17:48637367 CACNA1G -0.48 -6.94 -0.36 2.11e-11 Type 2 diabetes; CRC cis rs595982 0.559 rs73061632 chr19:49361663 G/A cg15549821 chr19:49342101 PLEKHA4 -0.59 -6.77 -0.35 6.01e-11 Red cell distribution width; CRC cis rs13315871 0.929 rs13094898 chr3:58290143 G/A cg20936604 chr3:58311152 NA -0.74 -6.94 -0.36 2.05e-11 Cholesterol, total; CRC cis rs11711311 1.000 rs2242109 chr3:113434100 G/T cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.52 -6.97 -0.36 1.77e-11 IgG glycosylation; CRC cis rs4713118 0.539 rs200951 chr6:27835930 A/G cg15786705 chr6:28176104 NA 0.54 7.43 0.38 9.41e-13 Parkinson's disease; CRC trans rs10982213 0.830 rs2274163 chr9:117188714 C/T cg02825653 chr17:7383046 ZBTB4 0.44 6.95 0.36 1.97e-11 Interleukin-6 levels; CRC cis rs769267 1.000 rs7246748 chr19:19433105 C/T cg02546618 chr19:19431379 KIAA0892;SF4 -0.47 -6.63 -0.34 1.36e-10 Tonsillectomy; CRC cis rs9611565 0.559 rs12483860 chr22:41961916 C/T cg03806693 chr22:41940476 POLR3H -0.89 -11.17 -0.52 8.84e-25 Vitiligo; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg07080049 chr9:96214194 FAM120A;FAM120AOS 0.54 7.71 0.39 1.52e-13 Response to antipsychotic treatment; CRC trans rs3808502 0.527 rs4410870 chr8:11156120 C/G cg16141378 chr3:129829833 LOC729375 0.43 6.27 0.33 1.13e-9 Neuroticism; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg11944815 chr12:125473709 DHX37 0.38 6.03 0.32 4.39e-9 Liver disease severity in Alagille syndrome; CRC cis rs6964587 1.000 rs34043009 chr7:91578447 T/C cg17063962 chr7:91808500 NA -0.79 -13.81 -0.61 1.52e-34 Breast cancer; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg20859470 chr1:153963593 RPS27 0.43 6.02 0.31 4.66e-9 Response to antipsychotic treatment; CRC cis rs875971 0.862 rs7798630 chr7:65771479 G/C cg00343986 chr7:65444356 GUSB -0.45 -6.25 -0.33 1.27e-9 Aortic root size; CRC trans rs10242455 1.000 rs6948775 chr7:98945480 A/G cg09045935 chr12:6379348 NA 0.73 6.83 0.35 4e-11 Blood metabolite levels; CRC cis rs2882667 0.690 rs11749163 chr5:138262670 A/G cg09476006 chr5:138032270 NA 0.58 10.08 0.49 5.28e-21 Age-related hearing impairment (SNP x SNP interaction); CRC trans rs1005277 0.579 rs2008449 chr10:38414204 A/T cg11292332 chr7:45801988 SEPT13 0.34 6.27 0.33 1.15e-9 Extrinsic epigenetic age acceleration; CRC cis rs853679 0.723 rs1736904 chr6:28219270 G/A cg12172441 chr6:28176163 NA 0.53 6.13 0.32 2.53e-9 Depression; CRC cis rs57502260 0.573 rs11228294 chr11:68388567 C/T cg01657329 chr11:68192670 LRP5 -0.46 -5.75 -0.3 2.07e-8 Total body bone mineral density (age 45-60); CRC cis rs4660306 0.677 rs11211110 chr1:45904815 C/T cg03123370 chr1:45965343 CCDC163P;MMACHC -0.52 -6.53 -0.34 2.47e-10 Homocysteine levels; CRC cis rs12908161 0.853 rs12912342 chr15:85248216 T/C cg17507749 chr15:85114479 UBE2QP1 0.57 8.06 0.41 1.41e-14 Schizophrenia; CRC trans rs61931739 0.500 rs11053210 chr12:34461771 A/G cg26384229 chr12:38710491 ALG10B -0.62 -8.21 -0.41 4.95e-15 Morning vs. evening chronotype; CRC cis rs6748734 1.000 rs4675874 chr2:241819796 A/G cg07537917 chr2:241836409 C2orf54 0.22 6.31 0.33 9.23e-10 Urinary metabolites; CRC cis rs929354 1.000 rs1182389 chr7:157038803 C/T cg17757837 chr7:157058334 UBE3C 0.81 14.83 0.63 1.79e-38 Body mass index; CRC cis rs17376456 0.825 rs13164315 chr5:93147421 A/G cg21475434 chr5:93447410 FAM172A 0.71 7.05 0.36 1.04e-11 Diabetic retinopathy; CRC cis rs1707322 0.964 rs1768802 chr1:46547868 A/G cg06784218 chr1:46089804 CCDC17 -0.55 -9.67 -0.47 1.26e-19 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs12745968 0.589 rs6697491 chr1:93032714 A/G cg17283838 chr1:93427260 FAM69A -0.47 -6.29 -0.33 1e-9 Bipolar disorder and schizophrenia; CRC cis rs9393777 0.582 rs6936561 chr6:26640895 C/T cg12292205 chr6:26970375 C6orf41 -0.6 -6.75 -0.35 6.71e-11 Intelligence (multi-trait analysis); CRC cis rs4481887 1.000 rs6697735 chr1:248465315 G/C cg00666640 chr1:248458726 OR2T12 0.52 9.29 0.46 2.23e-18 Common traits (Other); CRC cis rs769267 0.965 rs2965188 chr19:19522557 G/A cg02546618 chr19:19431379 KIAA0892;SF4 0.45 6.23 0.32 1.44e-9 Tonsillectomy; CRC cis rs9522267 0.535 rs9522299 chr13:112236013 C/A cg10483660 chr13:112241077 NA -0.48 -9.0 -0.44 1.85e-17 Hepatitis; CRC cis rs6694672 1.000 rs10754215 chr1:197086669 C/T cg13682187 chr1:196946512 CFHR5 0.44 7.19 0.37 4.38e-12 Asthma; CRC cis rs1045714 0.836 rs73033691 chr7:2636522 T/G cg24848437 chr7:2645542 IQCE 0.58 6.03 0.32 4.3e-9 Urate levels in lean individuals; CRC cis rs1865760 0.929 rs9467646 chr6:25957408 A/G cg17691542 chr6:26056736 HIST1H1C 0.56 8.59 0.43 3.5e-16 Height; CRC cis rs2243480 1.000 rs35825738 chr7:65318027 A/G cg18252515 chr7:66147081 NA -1.17 -13.57 -0.6 1.26e-33 Diabetic kidney disease; CRC cis rs9911578 1.000 rs2611782 chr17:56717956 T/C cg12560992 chr17:57184187 TRIM37 0.91 16.61 0.68 1.98e-45 Intelligence (multi-trait analysis); CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg25350635 chr12:49182847 ADCY6 0.36 6.01 0.31 5.02e-9 Obesity-related traits; CRC cis rs854765 0.927 rs12943914 chr17:17980671 A/G cg23957660 chr17:17878224 LRRC48 0.35 5.93 0.31 7.6e-9 Total body bone mineral density; CRC trans rs1005277 0.505 rs7917943 chr10:38195811 T/A cg23533926 chr12:111358616 MYL2 0.45 6.6 0.34 1.69e-10 Extrinsic epigenetic age acceleration; CRC trans rs1814175 0.817 rs7929173 chr11:49944007 T/C cg15704280 chr7:45808275 SEPT13 -1.02 -20.23 -0.74 1.07e-59 Height; CRC cis rs7843479 0.965 rs11135742 chr8:21802910 A/T cg17168535 chr8:21777572 XPO7 0.57 9.28 0.46 2.36e-18 Mean corpuscular volume; CRC cis rs597539 0.731 rs664229 chr11:68624483 C/G cg06112835 chr11:68658793 MRPL21 0.45 7.15 0.37 5.54e-12 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs1055129 0.516 rs7218498 chr17:73931847 C/G cg08125733 chr17:73851984 WBP2 0.5 6.65 0.34 1.2e-10 White matter hyperintensity burden; CRC cis rs2735413 0.846 rs72800943 chr16:78079555 G/A cg04733911 chr16:78082701 NA -0.44 -7.37 -0.38 1.38e-12 Systolic blood pressure (alcohol consumption interaction); CRC cis rs11958404 0.932 rs72816547 chr5:157417820 G/T cg05962755 chr5:157440814 NA 1.01 12.45 0.57 1.96e-29 IgG glycosylation; CRC cis rs11098499 0.955 rs6815725 chr4:120158410 C/A cg09307838 chr4:120376055 NA 0.62 9.62 0.47 1.88e-19 Corneal astigmatism; CRC cis rs453301 0.522 rs2929309 chr8:9083771 C/A cg06636001 chr8:8085503 FLJ10661 -0.57 -8.86 -0.44 5.09e-17 Joint mobility (Beighton score); CRC cis rs951366 0.764 rs823141 chr1:205741426 T/C cg17178900 chr1:205818956 PM20D1 0.68 10.18 0.49 2.4e-21 Menarche (age at onset); CRC cis rs7043114 0.525 rs9299404 chr9:95170338 A/G cg13798575 chr9:95087839 CENPP;NOL8 0.41 6.06 0.32 3.67e-9 Height; CRC trans rs2727020 0.658 rs1851992 chr11:49438110 C/T cg21153622 chr11:89784906 NA -0.37 -6.03 -0.32 4.36e-9 Coronary artery disease; CRC cis rs367943 0.901 rs171180 chr5:112817093 A/C cg12552261 chr5:112820674 MCC -0.49 -7.66 -0.39 2.06e-13 Type 2 diabetes; CRC cis rs7224685 0.859 rs34348519 chr17:4094140 G/C cg11204139 chr17:3907470 NA 0.41 5.69 0.3 2.82e-8 Type 2 diabetes; CRC cis rs9292777 0.681 rs2197426 chr5:40418273 C/G cg09067459 chr5:40385259 NA -0.55 -8.93 -0.44 3.12e-17 Crohn's disease;Multiple sclerosis; CRC cis rs11212617 0.967 rs227090 chr11:108241349 G/T cg01991180 chr11:108092276 ATM;NPAT 0.42 6.03 0.32 4.31e-9 Response to metformin in type 2 diabetes (glycemic); CRC cis rs7493 1.000 rs2040993 chr7:95047300 T/A cg04155289 chr7:94953770 PON1 -0.59 -7.48 -0.38 6.83e-13 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs6543140 0.964 rs2160200 chr2:103033963 G/T cg09003973 chr2:102972529 NA 0.41 5.68 0.3 2.96e-8 Blood protein levels; CRC cis rs17433780 0.504 rs4142706 chr1:89475230 A/C cg09516651 chr1:89888402 LOC400759 0.36 5.97 0.31 6.19e-9 Carotid intima media thickness; CRC cis rs7666738 0.830 rs2865990 chr4:99067399 C/A cg05340658 chr4:99064831 C4orf37 0.6 9.29 0.46 2.1e-18 Colonoscopy-negative controls vs population controls; CRC cis rs9916302 0.861 rs10491129 chr17:37461643 T/G cg00129232 chr17:37814104 STARD3 0.55 8.21 0.41 5.08e-15 Glomerular filtration rate (creatinine); CRC cis rs1816752 0.837 rs7139748 chr13:24985669 G/A cg02811702 chr13:24901961 NA 0.41 5.73 0.3 2.28e-8 Obesity-related traits; CRC cis rs4862750 0.872 rs1991254 chr4:187875375 T/G cg06074448 chr4:187884817 NA -0.6 -10.9 -0.52 7.91e-24 Lobe attachment (rater-scored or self-reported); CRC cis rs400736 0.930 rs226249 chr1:8021778 A/G cg25007680 chr1:8021821 PARK7 0.54 7.25 0.37 2.95e-12 Response to antidepressants and depression; CRC cis rs3857536 0.776 rs4710316 chr6:66935097 T/A cg07460842 chr6:66804631 NA -0.42 -5.71 -0.3 2.5e-8 Blood trace element (Cu levels); CRC cis rs1046896 0.739 rs28459016 chr17:80741194 G/A cg02398342 chr17:80708632 TBCD;FN3K 0.41 5.95 0.31 6.88e-9 Glycated hemoglobin levels; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg23471890 chr12:111051874 TCTN1 0.39 6.41 0.33 4.9e-10 Liver disease severity in Alagille syndrome; CRC cis rs7927592 0.913 rs12283755 chr11:68371658 A/G cg01657329 chr11:68192670 LRP5 -0.47 -6.69 -0.35 9.51e-11 Total body bone mineral density; CRC cis rs7258465 1.000 rs4808133 chr19:18608518 C/A cg10790698 chr19:18539756 SSBP4 -0.44 -8.44 -0.42 1e-15 Breast cancer; CRC cis rs6921919 0.583 rs11751693 chr6:28345083 C/T cg21251018 chr6:28226885 NKAPL 0.39 6.02 0.31 4.74e-9 Autism spectrum disorder or schizophrenia; CRC cis rs7072216 0.763 rs6584200 chr10:100170037 A/G cg26618903 chr10:100175079 PYROXD2 -0.55 -9.16 -0.45 5.81e-18 Metabolite levels; CRC cis rs3091242 0.900 rs4649086 chr1:25778967 T/A cg20684491 chr1:25596433 NA 0.43 7.39 0.38 1.23e-12 Erythrocyte sedimentation rate; CRC cis rs7223966 1.000 rs7217982 chr17:61832150 C/T cg05941027 chr17:61774174 LIMD2 0.35 6.23 0.32 1.45e-9 Hip circumference adjusted for BMI;Body mass index; CRC cis rs6754459 0.666 rs11674266 chr2:3705291 A/G cg25251562 chr2:3704773 ALLC -0.43 -6.42 -0.33 4.67e-10 Response to inhaled corticosteroid treatment in asthma (change in FEV1); CRC cis rs2153535 0.580 rs6918391 chr6:8461178 A/C cg21535247 chr6:8435926 SLC35B3 0.5 7.56 0.38 4.13e-13 Motion sickness; CRC cis rs2576037 0.526 rs1789152 chr18:44433092 G/T cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.63 -10.24 -0.49 1.51e-21 Personality dimensions; CRC cis rs2243480 1.000 rs36068983 chr7:65408991 C/T cg12463550 chr7:65579703 CRCP 0.62 5.95 0.31 6.68e-9 Diabetic kidney disease; CRC cis rs11696501 0.688 rs1013562 chr20:44310744 A/G cg11783356 chr20:44313418 WFDC10B -0.41 -6.23 -0.32 1.42e-9 Brain structure; CRC cis rs76878669 0.606 rs2282531 chr11:66099494 C/T cg18002602 chr11:66138449 SLC29A2 -0.29 -6.12 -0.32 2.63e-9 Educational attainment (years of education); CRC cis rs951366 0.789 rs823095 chr1:205679239 G/A cg14893161 chr1:205819251 PM20D1 0.81 12.47 0.57 1.66e-29 Menarche (age at onset); CRC cis rs13108904 0.539 rs13145722 chr4:1338422 T/A cg02018176 chr4:1364513 KIAA1530 0.4 5.92 0.31 8.31e-9 Obesity-related traits; CRC cis rs2153535 0.580 rs9328478 chr6:8519183 A/G cg21535247 chr6:8435926 SLC35B3 0.48 7.36 0.38 1.51e-12 Motion sickness; CRC cis rs10779751 1.000 rs12124983 chr1:11286178 C/T cg08854313 chr1:11322531 MTOR -0.75 -11.9 -0.55 2.12e-27 Body mass index; CRC cis rs2404602 0.716 rs17362383 chr15:76650702 A/G cg03037974 chr15:76606532 NA 0.71 12.4 0.56 3.06e-29 Blood metabolite levels; CRC cis rs2404602 0.532 rs284892 chr15:76721037 A/G cg03037974 chr15:76606532 NA 0.61 10.31 0.49 8.67e-22 Blood metabolite levels; CRC cis rs7107174 1.000 rs1399196 chr11:78071876 A/G cg12700464 chr11:78128424 GAB2 -0.46 -5.66 -0.3 3.37e-8 Testicular germ cell tumor; CRC cis rs4728302 0.608 rs6950383 chr7:133727497 C/T cg03336402 chr7:133662267 EXOC4 0.42 6.47 0.34 3.46e-10 Intelligence;Intelligence (multi-trait analysis); CRC cis rs875971 1.000 rs709595 chr7:65817333 G/C cg18876405 chr7:65276391 NA 0.53 9.12 0.45 7.62e-18 Aortic root size; CRC cis rs6582630 0.555 rs2387598 chr12:38510472 G/A cg26384229 chr12:38710491 ALG10B -0.65 -9.83 -0.48 3.72e-20 Drug-induced liver injury (flucloxacillin); CRC cis rs7408868 0.908 rs4809028 chr19:15273231 A/G cg14696996 chr19:15285081 NOTCH3 0.97 8.99 0.44 1.99e-17 Pulse pressure; CRC cis rs7666738 0.830 rs969048 chr4:98988921 T/C cg17366294 chr4:99064904 C4orf37 0.44 7.39 0.38 1.23e-12 Colonoscopy-negative controls vs population controls; CRC cis rs6565180 0.962 rs6565183 chr16:30382755 T/C cg17640201 chr16:30407289 ZNF48 -0.81 -14.33 -0.62 1.54e-36 Tonsillectomy; CRC trans rs2832191 0.671 rs68101501 chr21:30513229 G/T cg04295733 chr1:166845736 TADA1 -0.41 -5.98 -0.31 5.73e-9 Dental caries; CRC cis rs9916302 0.904 rs35285898 chr17:37555872 A/C cg00129232 chr17:37814104 STARD3 0.54 8.12 0.41 9.26e-15 Glomerular filtration rate (creatinine); CRC cis rs11098499 0.866 rs11098506 chr4:120284971 A/G cg24375607 chr4:120327624 NA 0.46 7.15 0.37 5.8e-12 Corneal astigmatism; CRC cis rs2749592 0.725 rs9417245 chr10:37826322 C/T cg25427524 chr10:38739819 LOC399744 0.6 8.31 0.42 2.53e-15 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs10499694 0.901 rs6975453 chr7:50585211 A/T cg14593290 chr7:50529359 DDC -0.42 -6.06 -0.32 3.76e-9 Body mass index; CRC cis rs1008375 1.000 rs7654345 chr4:17691796 A/G cg16339924 chr4:17578868 LAP3 0.47 6.31 0.33 8.96e-10 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs1552244 1.000 rs112509186 chr3:10156533 A/G cg08888203 chr3:10149979 C3orf24 0.7 9.38 0.46 1.14e-18 Alzheimer's disease; CRC cis rs7762018 0.941 rs4716387 chr6:170136777 G/C cg17545662 chr6:170176663 C6orf70 0.57 6.43 0.33 4.53e-10 Thiazide-induced adverse metabolic effects in hypertensive patients; CRC cis rs1153858 1.000 rs12593230 chr15:45646968 A/T cg21132104 chr15:45694354 SPATA5L1 0.58 8.5 0.42 6.88e-16 Homoarginine levels; CRC cis rs12586317 0.547 rs112138868 chr14:35444385 C/T cg05294307 chr14:35346193 BAZ1A -0.71 -7.72 -0.39 1.41e-13 Psoriasis; CRC cis rs10911232 0.507 rs10797821 chr1:183012559 G/A ch.1.3577855R chr1:183094577 LAMC1 0.83 14.57 0.63 1.8e-37 Hypertriglyceridemia; CRC cis rs2180341 0.781 rs877102 chr6:127587086 T/C cg27446573 chr6:127587934 RNF146 0.76 11.25 0.53 4.77e-25 Breast cancer; CRC cis rs11190604 1.000 rs2489040 chr10:102331298 G/A cg16342193 chr10:102329863 NA -0.36 -6.09 -0.32 3.06e-9 Palmitoleic acid (16:1n-7) levels; CRC cis rs2635047 0.713 rs28666933 chr18:44762408 C/T cg19077165 chr18:44547161 KATNAL2 -0.41 -6.03 -0.32 4.41e-9 Educational attainment; CRC cis rs1882538 0.503 rs13240997 chr7:133135373 C/A cg10665199 chr7:133106180 EXOC4 0.65 9.75 0.47 6.76e-20 Intelligence (multi-trait analysis); CRC cis rs6694672 1.000 rs9427942 chr1:196946448 G/A cg13682187 chr1:196946512 CFHR5 -0.5 -7.97 -0.4 2.59e-14 Asthma; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg24487361 chr1:231473529 EXOC8;C1orf124 0.37 6.16 0.32 2.11e-9 Liver disease severity in Alagille syndrome; CRC cis rs9911578 1.000 rs9898916 chr17:57048660 C/T cg05425664 chr17:57184151 TRIM37 -0.5 -7.81 -0.4 7.76e-14 Intelligence (multi-trait analysis); CRC cis rs1552244 0.608 rs3732962 chr3:10048951 T/C cg13047869 chr3:10149882 C3orf24 0.39 5.95 0.31 6.8e-9 Alzheimer's disease; CRC cis rs478304 0.654 rs10896034 chr11:65460783 T/A cg27068330 chr11:65405492 SIPA1 -0.66 -9.82 -0.48 4.09e-20 Acne (severe); CRC cis rs875971 0.929 rs778712 chr7:65849978 C/T cg12463550 chr7:65579703 CRCP 0.48 6.96 0.36 1.89e-11 Aortic root size; CRC cis rs13108904 0.901 rs4516656 chr4:1279860 A/G cg16405210 chr4:1374714 KIAA1530 -0.44 -5.94 -0.31 7.23e-9 Obesity-related traits; CRC cis rs6952808 0.609 rs12699449 chr7:1951227 G/C cg22963979 chr7:1858916 MAD1L1 -0.43 -6.77 -0.35 5.98e-11 Bipolar disorder and schizophrenia; CRC cis rs6546537 0.562 rs7565783 chr2:69750113 C/T cg10773587 chr2:69614142 GFPT1 -0.48 -6.48 -0.34 3.29e-10 Serum thyroid-stimulating hormone levels; CRC cis rs769267 0.965 rs2965198 chr19:19473030 A/G cg03709012 chr19:19516395 GATAD2A -0.73 -11.17 -0.52 9.27e-25 Tonsillectomy; CRC cis rs7833986 1.000 rs4263734 chr8:57099931 G/A cg23139584 chr8:56987506 RPS20;SNORD54 0.62 7.67 0.39 1.97e-13 Height; CRC cis rs7508679 1.000 rs7248104 chr19:7224431 A/G cg00428638 chr19:7224713 INSR 1.01 21.75 0.77 1.2e-65 Hypothyroidism; CRC cis rs35883536 0.967 rs2297713 chr1:101092766 T/G cg14515779 chr1:101123966 NA -0.43 -8.39 -0.42 1.49e-15 Monocyte count; CRC cis rs769267 0.899 rs67720221 chr19:19440864 C/T cg02546618 chr19:19431379 KIAA0892;SF4 -0.45 -6.23 -0.32 1.4e-9 Tonsillectomy; CRC cis rs10486722 0.651 rs12537065 chr7:41781911 A/G cg22138096 chr7:41772439 LOC285954 0.49 6.37 0.33 6.33e-10 Pit-and-Fissure caries; CRC cis rs62432291 0.681 rs445957 chr6:159662064 C/T cg14500486 chr6:159655392 FNDC1 -0.79 -10.63 -0.51 6.84e-23 Joint mobility (Beighton score); CRC trans rs7726839 0.540 rs72703078 chr5:594987 A/C cg11887960 chr12:57824829 NA 0.59 6.66 0.34 1.15e-10 Obesity-related traits; CRC cis rs17401966 0.538 rs7418410 chr1:10236402 A/G cg19773385 chr1:10388646 KIF1B 0.47 7.13 0.37 6.22e-12 Hepatocellular carcinoma; CRC cis rs2274471 0.645 rs73395330 chr9:5082839 C/T cg03390472 chr9:5043263 JAK2 -0.6 -7.05 -0.36 1.03e-11 Crohn's disease; CRC cis rs10464366 0.597 rs10951590 chr7:39091043 C/T cg18850127 chr7:39170497 POU6F2 0.44 5.82 0.31 1.36e-8 IgG glycosylation; CRC cis rs1552244 1.000 rs9879080 chr3:10084224 C/T cg16606324 chr3:10149918 C3orf24 0.7 9.66 0.47 1.31e-19 Alzheimer's disease; CRC cis rs10207060 0.500 rs72992164 chr2:240711780 G/A cg07506560 chr2:240697449 NA 0.48 6.37 0.33 6.49e-10 Obesity-related traits; CRC cis rs769267 0.965 rs2315281 chr19:19480099 G/A cg02546618 chr19:19431379 KIAA0892;SF4 -0.45 -6.25 -0.33 1.29e-9 Tonsillectomy; CRC cis rs7666738 0.830 rs28587201 chr4:98991733 C/T cg17366294 chr4:99064904 C4orf37 0.43 7.27 0.37 2.57e-12 Colonoscopy-negative controls vs population controls; CRC cis rs514406 0.525 rs269291 chr1:53189297 C/T cg27535305 chr1:53392650 SCP2 -0.36 -6.32 -0.33 8.45e-10 Monocyte count; CRC cis rs3749237 0.595 rs4855839 chr3:49507847 G/A cg02487422 chr3:49467188 NICN1 0.41 6.74 0.35 7.13e-11 Resting heart rate; CRC cis rs7246657 0.943 rs8111782 chr19:37867904 A/G cg23950597 chr19:37808831 NA -0.54 -6.5 -0.34 2.93e-10 Coronary artery calcification; CRC cis rs7586879 0.681 rs6752483 chr2:25120086 C/T cg04586622 chr2:25135609 ADCY3 -0.55 -10.21 -0.49 1.95e-21 Body mass index; CRC cis rs8105895 0.935 rs62112364 chr19:22294903 C/A cg02912127 chr19:22235281 ZNF257 -0.41 -5.6 -0.3 4.52e-8 Body mass index (change over time); CRC cis rs6964587 1.000 rs733957 chr7:91707197 C/T cg17063962 chr7:91808500 NA 0.78 13.6 0.6 9.81e-34 Breast cancer; CRC cis rs7568498 0.564 rs10490563 chr2:161914168 G/A cg22496339 chr2:162101262 NA -0.54 -7.29 -0.37 2.26e-12 Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 3 peripheral neuropathy); CRC cis rs2153535 0.623 rs2327055 chr6:8443145 A/G cg21535247 chr6:8435926 SLC35B3 0.49 7.27 0.37 2.65e-12 Motion sickness; CRC cis rs514406 0.505 rs269286 chr1:53169018 C/T cg27535305 chr1:53392650 SCP2 0.33 5.74 0.3 2.1e-8 Monocyte count; CRC cis rs858239 1.000 rs156425 chr7:23309119 C/T cg00469287 chr7:23338798 C7orf30 -0.5 -6.74 -0.35 7.05e-11 Cerebrospinal fluid biomarker levels; CRC cis rs826838 0.967 rs1486345 chr12:39131677 G/A cg26384229 chr12:38710491 ALG10B -0.64 -9.71 -0.47 9.47e-20 Heart rate; CRC cis rs9322193 0.923 rs9767105 chr6:149980727 A/G cg13206674 chr6:150067644 NUP43 0.64 9.58 0.47 2.54e-19 Lung cancer; CRC cis rs2075371 0.501 rs1643043 chr7:134013902 C/T cg20476274 chr7:133979776 SLC35B4 0.61 9.4 0.46 9.32e-19 Mean platelet volume; CRC cis rs870825 0.616 rs10006828 chr4:185651416 C/T cg04058563 chr4:185651563 MLF1IP 0.71 9.15 0.45 6.3e-18 Blood protein levels; CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg00814883 chr7:100076585 TSC22D4 0.39 6.11 0.32 2.76e-9 Obesity-related traits; CRC cis rs1697139 0.583 rs11739727 chr5:66540940 G/A cg16691251 chr5:66510806 NA 0.41 7.18 0.37 4.7e-12 Breast cancer; CRC cis rs57221529 0.825 rs7443550 chr5:578404 G/T cg16447950 chr5:562315 NA -0.83 -10.81 -0.51 1.71e-23 Lung disease severity in cystic fibrosis; CRC trans rs58688157 0.705 rs12803132 chr11:586696 A/G cg19188899 chr13:112838565 NA -0.42 -6.28 -0.33 1.05e-9 Systemic lupus erythematosus; CRC cis rs9381040 0.748 rs9357348 chr6:41154232 A/G cg09580153 chr6:41068724 NFYA;LOC221442 -0.41 -6.0 -0.31 5.3e-9 Alzheimer's disease (late onset); CRC cis rs8105895 0.935 rs6511321 chr19:22270068 A/G cg02657401 chr19:22469223 NA -0.35 -5.78 -0.3 1.75e-8 Body mass index (change over time); CRC cis rs6502050 0.835 rs4789744 chr17:80101506 A/C cg22110888 chr17:80059540 CCDC57 0.4 6.44 0.33 4.17e-10 Life satisfaction; CRC cis rs939584 1.000 rs7560127 chr2:643315 T/C cg03610516 chr2:642275 NA 0.41 5.74 0.3 2.18e-8 Body mass index; CRC cis rs9611565 0.503 rs5751156 chr22:42170025 A/G cg06634786 chr22:41940651 POLR3H 0.67 7.42 0.38 1.01e-12 Vitiligo; CRC cis rs10791097 0.739 rs4936120 chr11:130723452 G/A cg12179176 chr11:130786555 SNX19 0.72 11.15 0.52 1.02e-24 Autism spectrum disorder or schizophrenia;Schizophrenia; CRC cis rs11155671 0.530 rs4458704 chr6:150232879 A/C cg05861140 chr6:150128134 PCMT1 -0.34 -5.7 -0.3 2.71e-8 Testicular germ cell tumor; CRC cis rs1862618 0.671 rs2591955 chr5:56244948 C/T cg20203395 chr5:56204925 C5orf35 0.58 8.0 0.4 2.11e-14 Initial pursuit acceleration; CRC trans rs1814175 0.588 rs10839463 chr11:49971643 A/G cg11707556 chr5:10655725 ANKRD33B -0.51 -9.81 -0.48 4.26e-20 Height; CRC cis rs10256972 0.552 rs2960831 chr7:1201192 A/T cg09177884 chr7:1199841 ZFAND2A -0.54 -8.19 -0.41 5.78e-15 Longevity;Endometriosis; CRC cis rs2760061 0.598 rs1774755 chr1:228115282 T/G cg02753203 chr1:228287806 NA -0.59 -8.68 -0.43 1.87e-16 Diastolic blood pressure; CRC cis rs7527798 0.592 rs6671969 chr1:207839667 C/T cg21110645 chr1:207815933 NA -0.43 -6.69 -0.35 9.56e-11 Erythrocyte sedimentation rate; CRC cis rs9467711 0.559 rs9348721 chr6:26485573 A/G cg16898833 chr6:26189333 HIST1H4D 0.85 7.14 0.37 5.87e-12 Autism spectrum disorder or schizophrenia; CRC cis rs7811142 0.830 rs75636500 chr7:99947657 C/G cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.71 8.99 0.44 1.92e-17 Platelet count; CRC cis rs2288073 0.965 rs36101491 chr2:24387532 C/T cg06627628 chr2:24431161 ITSN2 -0.76 -10.31 -0.49 8.7e-22 Venous thromboembolism (SNP x SNP interaction); CRC trans rs1814175 0.765 rs1721990 chr11:49912154 G/C cg11707556 chr5:10655725 ANKRD33B -0.43 -8.13 -0.41 9.13e-15 Height; CRC cis rs644799 0.562 rs1254989 chr11:95508121 A/G cg25622487 chr11:95524042 FAM76B;CEP57 0.66 9.86 0.48 2.94e-20 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs17125944 0.686 rs2296495 chr14:53379878 G/A cg00686598 chr14:53173677 PSMC6 0.79 6.38 0.33 5.89e-10 Alzheimer's disease (late onset); CRC cis rs28386778 0.897 rs7501614 chr17:61802612 T/C cg06601766 chr17:61851465 DDX42;CCDC47 0.44 5.97 0.31 6.3e-9 Prudent dietary pattern; CRC cis rs6908034 0.556 rs113071446 chr6:19810835 A/C cg02682789 chr6:19804855 NA 0.81 6.48 0.34 3.35e-10 Endometriosis;Deep ovarian and/or rectovaginal disease with dense adhesions; CRC cis rs67340775 0.541 rs200974 chr6:27855845 A/G cg02683197 chr6:28174875 NA 0.68 6.72 0.35 8.24e-11 Lung cancer in ever smokers; CRC cis rs939658 0.776 rs68147688 chr15:79443848 G/A cg17916960 chr15:79447300 NA -0.44 -7.15 -0.37 5.54e-12 Refractive error; CRC trans rs2243480 1.000 rs313803 chr7:65514731 G/A cg10756647 chr7:56101905 PSPH 0.75 7.66 0.39 2.05e-13 Diabetic kidney disease; CRC cis rs875971 0.862 rs35378740 chr7:65987712 C/A cg00343986 chr7:65444356 GUSB 0.44 6.15 0.32 2.21e-9 Aortic root size; CRC cis rs1008375 1.000 rs28552744 chr4:17620165 A/G cg16339924 chr4:17578868 LAP3 0.54 7.35 0.38 1.58e-12 Parasitemia in Tripanosoma cruzi seropositivity; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg13009927 chr2:242254519 SEPT2;HDLBP -0.44 -6.37 -0.33 6.44e-10 Myopia (pathological); CRC trans rs6539288 0.803 rs10778517 chr12:107341664 G/T cg08487696 chr7:150945928 SMARCD3 -0.45 -6.41 -0.33 5.14e-10 Total body bone mineral density; CRC cis rs801193 0.569 rs2659893 chr7:66199993 G/A cg12463550 chr7:65579703 CRCP 0.45 6.12 0.32 2.72e-9 Aortic root size; CRC cis rs798554 0.718 rs1636247 chr7:2881917 A/G cg13628971 chr7:2884303 GNA12 0.6 8.15 0.41 7.75e-15 Height; CRC cis rs881375 0.678 rs4836834 chr9:123665901 T/A cg09419670 chr9:123605666 PSMD5;LOC253039 0.52 8.32 0.42 2.35e-15 Rheumatoid arthritis; CRC cis rs1568889 1.000 rs61889054 chr11:28333000 A/C cg06544937 chr11:28130018 METT5D1;KIF18A 0.78 10.61 0.5 8.09e-23 Bipolar disorder; CRC cis rs7726839 0.574 rs11739866 chr5:636299 C/T cg14541582 chr5:601475 NA -0.36 -7.3 -0.37 2.21e-12 Obesity-related traits; CRC cis rs1322639 0.614 rs9364361 chr6:169580499 C/T cg04662567 chr6:169592167 NA -0.41 -5.76 -0.3 1.98e-8 Pulse pressure; CRC cis rs7811142 0.943 rs28578163 chr7:100044754 A/G cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.16 17.98 0.7 7.57e-51 Platelet count; CRC cis rs4319547 1.000 rs6489156 chr12:123100397 C/T cg23029597 chr12:123009494 RSRC2 -0.6 -7.85 -0.4 6.05e-14 Body mass index; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg08762750 chr15:91497995 RCCD1 0.45 6.14 0.32 2.43e-9 Anxiety disorder; CRC cis rs4563143 0.675 rs55884228 chr19:29243897 G/T cg12667521 chr19:29218732 NA 0.49 7.49 0.38 6.26e-13 Methadone dose in opioid dependence; CRC cis rs933688 1.000 rs11948075 chr5:90680579 A/G cg02339078 chr5:90679543 LOC100129716;ARRDC3 0.92 13.87 0.61 9.28e-35 Smoking behavior; CRC cis rs7605827 0.930 rs722327 chr2:15657263 T/A cg19274914 chr2:15703543 NA 0.39 5.89 0.31 9.8e-9 Educational attainment (years of education); CRC cis rs1552244 0.810 rs35711405 chr3:10116939 C/T cg02579736 chr3:10068473 FANCD2;CIDECP 1.02 13.77 0.6 2.25e-34 Alzheimer's disease; CRC cis rs7945705 0.870 rs10840142 chr11:8906078 A/G cg21881798 chr11:8931708 C11orf17;ST5 0.67 10.35 0.5 6.28e-22 Hemoglobin concentration; CRC cis rs2115630 0.645 rs3825877 chr15:85174631 G/A cg17507749 chr15:85114479 UBE2QP1 -0.4 -6.0 -0.31 5.17e-9 P wave terminal force; CRC cis rs9916302 0.904 rs55689507 chr17:37404436 G/C cg00129232 chr17:37814104 STARD3 -0.54 -7.97 -0.4 2.67e-14 Glomerular filtration rate (creatinine); CRC cis rs13256369 1.000 rs13282915 chr8:8570891 T/G cg06671706 chr8:8559999 CLDN23 0.54 7.86 0.4 5.58e-14 Obesity-related traits; CRC cis rs2243480 1.000 rs1267820 chr7:66050295 C/G cg25985355 chr7:65971099 NA -0.53 -6.02 -0.32 4.65e-9 Diabetic kidney disease; CRC cis rs9435341 0.965 rs55909997 chr1:107581039 G/A cg11070056 chr1:107600091 PRMT6 0.4 5.68 0.3 3.01e-8 Facial morphology (factor 21, depth of nasal alae); CRC cis rs6752107 1.000 rs3828309 chr2:234180410 C/T cg07618928 chr2:234183455 ATG16L1;SCARNA5 -0.62 -10.61 -0.5 8.23e-23 Crohn's disease;Inflammatory bowel disease; CRC cis rs561341 0.769 rs12941700 chr17:30185022 A/G cg23018236 chr17:30244563 NA 0.49 5.78 0.3 1.77e-8 Hip circumference adjusted for BMI; CRC trans rs7726839 0.526 rs11960158 chr5:568665 C/T cg25482853 chr8:67687455 SGK3 0.98 12.17 0.56 2.19e-28 Obesity-related traits; CRC cis rs1799949 0.896 rs8176086 chr17:41274778 G/A cg01879757 chr17:41196368 BRCA1 -0.43 -6.61 -0.34 1.52e-10 Menopause (age at onset); CRC cis rs908922 0.676 rs493133 chr1:152493875 G/C cg23254163 chr1:152506842 NA 0.5 10.14 0.49 3.42e-21 Hair morphology; CRC cis rs9322193 0.962 rs9322206 chr6:149962617 T/C cg00933542 chr6:150070202 PCMT1 0.28 5.71 0.3 2.51e-8 Lung cancer; CRC cis rs7666738 0.830 rs10050008 chr4:99025313 T/G cg17366294 chr4:99064904 C4orf37 0.44 7.48 0.38 6.96e-13 Colonoscopy-negative controls vs population controls; CRC cis rs9322193 0.923 rs10872644 chr6:150062955 T/C cg07701084 chr6:150067640 NUP43 0.61 9.11 0.45 8.24e-18 Lung cancer; CRC cis rs6964587 0.904 rs2023785 chr7:91547369 C/A cg17063962 chr7:91808500 NA -0.75 -12.63 -0.57 4.47e-30 Breast cancer; CRC trans rs7800418 0.784 rs882540 chr7:26589889 G/A cg14387656 chr2:233470847 EFHD1 0.47 6.51 0.34 2.79e-10 Cognitive function; CRC cis rs9487051 0.724 rs13196219 chr6:109635787 A/T cg01475377 chr6:109611718 NA -0.38 -5.89 -0.31 9.3e-9 Reticulocyte fraction of red cells; CRC cis rs4665809 0.838 rs6546780 chr2:26352857 T/C cg04944784 chr2:26401820 FAM59B -0.62 -7.91 -0.4 3.97e-14 Gut microbiome composition (summer); CRC cis rs7412746 0.611 rs12085336 chr1:150775780 A/T cg17724175 chr1:150552817 MCL1 0.46 7.02 0.36 1.28e-11 Melanoma; CRC cis rs6570726 0.818 rs437978 chr6:145809134 A/G cg23711669 chr6:146136114 FBXO30 0.65 11.29 0.53 3.37e-25 Lobe attachment (rater-scored or self-reported); CRC cis rs896854 0.654 rs1453377 chr8:95969947 C/T cg16049864 chr8:95962084 TP53INP1 -0.6 -11.01 -0.52 3.33e-24 Type 2 diabetes; CRC cis rs9900062 0.586 rs6504250 chr17:62680553 T/C cg02097616 chr17:62675921 NA 0.5 6.91 0.36 2.46e-11 QT interval; CRC trans rs1814175 0.708 rs10839464 chr11:49981386 T/C cg03929089 chr4:120376271 NA -0.91 -16.17 -0.67 1.06e-43 Height; CRC cis rs10883723 0.810 rs1056857 chr10:104240003 C/T cg11453585 chr10:104263688 ACTR1A;SUFU 0.9 15.53 0.65 3.63e-41 Allergic disease (asthma, hay fever or eczema); CRC cis rs9467711 0.538 rs36012762 chr6:25980523 A/C cg08501292 chr6:25962987 TRIM38 0.84 7.74 0.39 1.24e-13 Autism spectrum disorder or schizophrenia; CRC cis rs10256972 0.552 rs2960831 chr7:1201192 A/T cg18402987 chr7:1209562 NA 0.6 9.31 0.46 1.84e-18 Longevity;Endometriosis; CRC cis rs7677751 0.806 rs4864860 chr4:55090021 T/C cg17187183 chr4:55093834 PDGFRA 0.53 7.83 0.4 6.85e-14 Corneal astigmatism; CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg16092956 chr4:185747098 ACSL1 -0.55 -6.75 -0.35 6.59e-11 Diisocyanate-induced asthma; CRC cis rs2243480 0.808 rs12698508 chr7:65411958 A/T cg25985355 chr7:65971099 NA -0.5 -5.86 -0.31 1.11e-8 Diabetic kidney disease; CRC cis rs7591163 1.000 rs1721359 chr2:228751874 C/T cg20647610 chr2:228736258 WDR69 -0.5 -6.71 -0.35 8.29e-11 Blood pressure; CRC cis rs10743315 0.643 rs75009806 chr12:19466457 A/G cg02471346 chr12:19282374 PLEKHA5 0.81 6.16 0.32 2.18e-9 Gut microbiota (bacterial taxa); CRC cis rs9372498 0.505 rs62422247 chr6:118987559 G/T cg24463073 chr6:118973353 C6orf204 0.49 6.07 0.32 3.48e-9 Diastolic blood pressure; CRC cis rs7666738 0.791 rs4699329 chr4:99056212 G/A cg17366294 chr4:99064904 C4orf37 0.46 7.72 0.39 1.4e-13 Colonoscopy-negative controls vs population controls; CRC cis rs9291683 0.588 rs2240721 chr4:10020564 G/A cg11266682 chr4:10021025 SLC2A9 0.54 11.58 0.54 2.96e-26 Bone mineral density; CRC cis rs11105298 0.891 rs10858871 chr12:89871613 G/A cg08166232 chr12:89918718 WDR51B;GALNT4 -0.61 -7.7 -0.39 1.62e-13 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; CRC cis rs7618915 0.547 rs12496476 chr3:52708737 A/G cg18099408 chr3:52552593 STAB1 -0.44 -7.16 -0.37 5.27e-12 Bipolar disorder; CRC cis rs1707322 1.000 rs785467 chr1:46521559 A/T cg06784218 chr1:46089804 CCDC17 -0.6 -10.55 -0.5 1.37e-22 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs2991971 0.967 rs2275276 chr1:45973928 C/T cg03123370 chr1:45965343 CCDC163P;MMACHC -0.38 -5.85 -0.31 1.17e-8 High light scatter reticulocyte count; CRC cis rs13256369 0.950 rs13270006 chr8:8574197 C/A cg06636001 chr8:8085503 FLJ10661 0.45 5.79 0.3 1.65e-8 Obesity-related traits; CRC cis rs6840360 0.571 rs11729136 chr4:152529227 C/A cg09659197 chr4:152720779 NA 0.32 5.75 0.3 2.02e-8 Intelligence (multi-trait analysis); CRC cis rs939584 1.000 rs4452188 chr2:648810 A/G cg03610516 chr2:642275 NA -0.42 -5.85 -0.31 1.2e-8 Body mass index; CRC cis rs933688 1.000 rs2059207 chr5:90731931 C/A cg26981201 chr5:90679533 LOC100129716;ARRDC3 0.96 16.45 0.67 8.44e-45 Smoking behavior; CRC cis rs6963495 0.818 rs9769403 chr7:105163091 G/A cg13798780 chr7:105162888 PUS7 0.68 8.08 0.41 1.27e-14 Bipolar disorder (body mass index interaction); CRC cis rs6089584 0.816 rs4925336 chr20:60627180 A/G cg23262073 chr20:60523788 NA -0.48 -7.58 -0.39 3.59e-13 Body mass index; CRC cis rs7739232 0.920 rs75332545 chr6:53527070 A/G cg15658676 chr6:53530538 KLHL31 -0.76 -5.9 -0.31 8.9e-9 Hip circumference adjusted for BMI; CRC trans rs2710642 0.777 rs2539987 chr2:63142864 A/G cg05376469 chr2:102649931 NA -0.38 -6.26 -0.33 1.23e-9 LDL cholesterol levels;LDL cholesterol; CRC cis rs7412746 0.658 rs4537557 chr1:150734436 A/G cg10589385 chr1:150898437 SETDB1 0.31 6.34 0.33 7.79e-10 Melanoma; CRC cis rs921968 0.510 rs2577761 chr2:219462500 G/A cg02176678 chr2:219576539 TTLL4 0.54 8.62 0.43 2.78e-16 Mean corpuscular hemoglobin concentration; CRC cis rs919433 0.929 rs1366836 chr2:198172148 T/G cg03934865 chr2:198174659 NA -0.46 -8.31 -0.42 2.5e-15 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC cis rs11971779 0.752 rs4732371 chr7:139077317 T/A cg07862535 chr7:139043722 LUC7L2 0.82 10.44 0.5 3.11e-22 Diisocyanate-induced asthma; CRC trans rs208520 0.661 rs704519 chr6:66801136 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.07 -15.3 -0.64 2.65e-40 Exhaled nitric oxide output; CRC cis rs877282 0.898 rs11253339 chr10:759640 C/T cg06581033 chr10:766294 NA -0.51 -5.74 -0.3 2.14e-8 Uric acid levels; CRC cis rs13108904 0.870 rs1960426 chr4:1274365 C/T cg21620606 chr4:1342894 KIAA1530 0.37 6.45 0.34 3.9e-10 Obesity-related traits; CRC cis rs13108904 0.905 rs1680074 chr4:1279621 G/A cg20887711 chr4:1340912 KIAA1530 -0.48 -7.13 -0.37 6.43e-12 Obesity-related traits; CRC cis rs7647973 0.554 rs13096480 chr3:49658084 A/G cg13072238 chr3:49761600 GMPPB -0.51 -5.86 -0.31 1.15e-8 Menarche (age at onset); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg12086046 chr17:5389958 MIS12;DERL2 0.46 6.68 0.35 1.04e-10 Intelligence (multi-trait analysis); CRC trans rs2840044 1.000 rs11656138 chr17:33910218 T/C cg19694781 chr19:47549865 TMEM160 0.44 7.01 0.36 1.36e-11 Response to radiotherapy in cancer (late toxicity); CRC cis rs2457480 0.657 rs2624683 chr10:44679140 A/G cg09554077 chr10:44749378 NA 0.51 7.02 0.36 1.31e-11 Coronary artery disease; CRC cis rs17067123 0.614 rs72712852 chr4:180066270 T/C cg26610307 chr4:180072759 NA -0.56 -6.74 -0.35 7.28e-11 Response to hepatitis C treatment; CRC cis rs2180341 0.961 rs3798857 chr6:127659473 A/T cg27446573 chr6:127587934 RNF146 0.98 14.42 0.62 6.85e-37 Breast cancer; CRC cis rs929354 0.772 rs1182432 chr7:157029176 A/G cg17757837 chr7:157058334 UBE3C 0.76 13.14 0.59 5.49e-32 Body mass index; CRC cis rs5769765 0.773 rs9616378 chr22:50311973 A/G cg04121214 chr22:50244548 NA 0.42 5.97 0.31 6.05e-9 Schizophrenia; CRC cis rs501120 0.564 rs7917089 chr10:44688587 G/A cg09554077 chr10:44749378 NA 0.55 7.67 0.39 1.95e-13 Coronary artery disease;Coronary heart disease; CRC cis rs1008375 0.897 rs67455495 chr4:17665238 A/T cg16339924 chr4:17578868 LAP3 -0.53 -6.57 -0.34 1.96e-10 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs6912958 0.781 rs4707379 chr6:88310623 A/G cg08069147 chr6:88032118 GJB7;C6orf162 -0.57 -8.59 -0.43 3.63e-16 Monocyte percentage of white cells; CRC trans rs9858542 0.953 rs1987628 chr3:49399259 G/A cg21582582 chr3:182698605 DCUN1D1 -0.52 -6.66 -0.34 1.12e-10 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs56775891 0.537 rs7236339 chr18:77579773 C/T cg24058013 chr18:77568902 NA -0.41 -6.08 -0.32 3.31e-9 Schizophrenia; CRC cis rs863345 0.604 rs12133794 chr1:158506697 C/G cg12129480 chr1:158549410 OR10X1 -0.3 -6.16 -0.32 2.18e-9 Pneumococcal bacteremia; CRC cis rs651907 0.535 rs11716558 chr3:101528481 T/C cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.59 7.86 0.4 5.42e-14 Colorectal cancer; CRC cis rs9372498 0.536 rs9320656 chr6:118894468 A/G cg24463073 chr6:118973353 C6orf204 -0.51 -6.88 -0.35 3.02e-11 Diastolic blood pressure; CRC cis rs8180040 0.903 rs7636423 chr3:47309134 C/G cg10298567 chr3:47292165 KIF9 -0.41 -6.78 -0.35 5.51e-11 Colorectal cancer; CRC cis rs929354 0.742 rs7784442 chr7:156934475 G/C cg17757837 chr7:157058334 UBE3C 0.74 12.39 0.56 3.31e-29 Body mass index; CRC cis rs7552404 0.731 rs11161836 chr1:76354333 C/T cg22875332 chr1:76189707 ACADM 0.65 7.85 0.4 5.96e-14 Blood metabolite levels;Acylcarnitine levels; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg01865113 chr17:70117105 SOX9 0.41 5.96 0.31 6.46e-9 Response to antipsychotic treatment; CRC cis rs7647973 1.000 rs4241407 chr3:49600319 C/T cg07636037 chr3:49044803 WDR6 0.67 8.24 0.41 4.06e-15 Menarche (age at onset); CRC cis rs12142240 0.698 rs17357628 chr1:46808462 A/G cg00530320 chr1:46809349 NSUN4 0.58 7.98 0.4 2.46e-14 Menopause (age at onset); CRC trans rs4263408 0.934 rs9683743 chr4:39703194 A/C cg04793015 chr2:86790474 VPS24 -0.45 -6.53 -0.34 2.51e-10 Plasma amyloid beta peptide concentrations (ABx-40); CRC cis rs78545713 0.649 rs79988778 chr6:26210621 G/T cg01420254 chr6:26195488 NA 0.69 6.13 0.32 2.45e-9 Iron status biomarkers (total iron binding capacity); CRC cis rs7618501 0.601 rs2624825 chr3:50154989 G/A cg24110177 chr3:50126178 RBM5 0.5 7.86 0.4 5.58e-14 Intelligence (multi-trait analysis); CRC cis rs2070488 0.804 rs13092473 chr3:38458958 A/G cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.78 13.35 0.59 8.6e-33 Electrocardiographic conduction measures; CRC cis rs853679 0.517 rs9380049 chr6:28048535 A/G cg15786705 chr6:28176104 NA 0.73 9.31 0.46 1.85e-18 Depression; CRC cis rs67311347 1.000 rs1123019 chr3:40488280 C/T cg09455208 chr3:40491958 NA 0.49 9.63 0.47 1.66e-19 Renal cell carcinoma; CRC cis rs2204008 0.775 rs11514369 chr12:38305411 C/T cg26384229 chr12:38710491 ALG10B 0.69 9.74 0.47 7.18e-20 Bladder cancer; CRC trans rs11148252 0.514 rs3818422 chr13:52719214 C/T cg18335740 chr13:41363409 SLC25A15 -0.47 -6.95 -0.36 1.97e-11 Lewy body disease; CRC trans rs7615952 0.512 rs2979336 chr3:125357470 G/A cg16558177 chr4:4109446 NA -0.62 -8.7 -0.43 1.58e-16 Blood pressure (smoking interaction); CRC cis rs67340775 0.541 rs200965 chr6:27866384 G/A cg25164649 chr6:28176230 NA 0.63 6.3 0.33 9.8e-10 Lung cancer in ever smokers; CRC cis rs4319547 0.695 rs4758662 chr12:122924778 G/A cg23029597 chr12:123009494 RSRC2 -0.54 -6.71 -0.35 8.41e-11 Body mass index; CRC cis rs12142240 0.698 rs41294456 chr1:46809782 T/C cg00530320 chr1:46809349 NSUN4 0.58 7.98 0.4 2.46e-14 Menopause (age at onset); CRC cis rs7493 1.000 rs17876123 chr7:95045307 C/A cg21856205 chr7:94953877 PON1 -0.51 -6.51 -0.34 2.73e-10 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs4713118 0.955 rs9393848 chr6:27688369 C/T cg12172441 chr6:28176163 NA 0.49 6.52 0.34 2.68e-10 Parkinson's disease; CRC cis rs2276314 0.857 rs3737474 chr18:33613595 T/C cg19628046 chr18:33552617 C18orf21 0.55 7.23 0.37 3.32e-12 Endometriosis;Drug-induced torsades de pointes; CRC cis rs13118159 0.550 rs28522910 chr4:1374774 C/T cg02475777 chr4:1388615 CRIPAK 0.49 6.33 0.33 7.85e-10 Longevity; CRC cis rs7927771 0.864 rs11604680 chr11:47457539 A/G cg05585544 chr11:47624801 NA -0.59 -10.68 -0.51 4.72e-23 Subjective well-being; CRC cis rs2839186 0.770 rs2839984 chr21:47671690 A/G cg13012494 chr21:47604986 C21orf56 0.44 6.94 0.36 2.04e-11 Testicular germ cell tumor; CRC cis rs728616 0.867 rs77376252 chr10:81809382 C/T cg05935833 chr10:81318306 SFTPA2 -0.57 -6.65 -0.34 1.26e-10 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs7772486 0.743 rs2092262 chr6:146037105 C/T cg23711669 chr6:146136114 FBXO30 -0.65 -10.88 -0.51 9.23e-24 Lobe attachment (rater-scored or self-reported); CRC cis rs8180040 0.726 rs1463393 chr3:46994987 G/A cg27129171 chr3:47204927 SETD2 -0.72 -11.4 -0.53 1.32e-25 Colorectal cancer; CRC cis rs870825 0.929 rs55746424 chr4:185589603 C/T cg04058563 chr4:185651563 MLF1IP 0.69 7.02 0.36 1.27e-11 Blood protein levels; CRC cis rs9359856 0.564 rs72915918 chr6:90430792 G/C cg13799429 chr6:90582589 CASP8AP2 -0.76 -7.71 -0.39 1.51e-13 Bipolar disorder; CRC cis rs1348850 0.526 rs59972556 chr2:178399561 A/G cg27490568 chr2:178487706 NA 0.59 7.14 0.37 5.85e-12 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs10504229 0.906 rs58559296 chr8:58171714 T/C cg05313129 chr8:58192883 C8orf71 -0.47 -6.99 -0.36 1.49e-11 Developmental language disorder (linguistic errors); CRC cis rs748404 0.631 rs6493084 chr15:43647627 A/G cg02155558 chr15:43621948 ADAL;LCMT2 0.54 7.89 0.4 4.53e-14 Lung cancer; CRC cis rs77633900 0.502 rs116917406 chr15:76922940 T/C cg21673338 chr15:77095150 SCAPER -0.76 -6.3 -0.33 9.7e-10 Non-glioblastoma glioma;Glioma; CRC cis rs7209700 0.644 rs7214468 chr17:45370766 G/A cg08085267 chr17:45401833 C17orf57 0.5 7.37 0.38 1.36e-12 IgG glycosylation; CRC cis rs17270561 0.609 rs1317817 chr6:25765377 G/A cg16482183 chr6:26056742 HIST1H1C 0.74 9.28 0.46 2.32e-18 Iron status biomarkers; CRC cis rs929354 0.739 rs1182439 chr7:157027367 G/A cg17757837 chr7:157058334 UBE3C -0.75 -13.04 -0.58 1.25e-31 Body mass index; CRC cis rs13082711 0.689 rs34641383 chr3:27320210 G/A cg02860705 chr3:27208620 NA 0.91 11.36 0.53 1.9e-25 Systolic blood pressure;Diastolic blood pressure;Blood pressure; CRC trans rs459571 0.959 rs465535 chr9:136910905 C/T cg09836344 chr4:1243392 C4orf42;CTBP1 -0.77 -11.06 -0.52 2.23e-24 Platelet distribution width; CRC trans rs1814175 0.645 rs1874969 chr11:49826700 G/A cg11707556 chr5:10655725 ANKRD33B -0.5 -9.37 -0.46 1.18e-18 Height; CRC cis rs10504229 1.000 rs34616626 chr8:58184650 C/T cg22535103 chr8:58192502 C8orf71 -0.82 -12.27 -0.56 9.63e-29 Developmental language disorder (linguistic errors); CRC cis rs12580194 1.000 rs12579915 chr12:55696789 C/T cg19537932 chr12:55886519 OR6C68 0.56 7.91 0.4 3.9e-14 Cancer; CRC cis rs6815814 0.950 rs73236618 chr4:38794041 T/C cg06935464 chr4:38784597 TLR10 0.58 5.89 0.31 9.66e-9 Breast cancer; CRC cis rs6693567 0.586 rs9661040 chr1:150483236 A/C cg04165759 chr1:150448943 RPRD2 0.36 5.79 0.3 1.63e-8 Migraine; CRC cis rs250677 0.958 rs17109282 chr5:148416677 A/G cg23229984 chr5:148520753 ABLIM3 -0.49 -6.79 -0.35 5.16e-11 Breast cancer; CRC cis rs17270561 0.609 rs1892254 chr6:25750530 T/C cg16482183 chr6:26056742 HIST1H1C 0.81 9.93 0.48 1.71e-20 Iron status biomarkers; CRC cis rs8072100 0.846 rs7214799 chr17:45702099 C/T cg25173405 chr17:45401733 C17orf57 0.4 6.02 0.31 4.71e-9 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs4409675 0.576 rs6679432 chr1:28227665 T/C cg23691781 chr1:28212827 C1orf38 0.33 7.72 0.39 1.37e-13 Corneal astigmatism; CRC cis rs7617773 0.817 rs34728236 chr3:48259108 A/G cg11946769 chr3:48343235 NME6 0.73 9.78 0.47 5.46e-20 Coronary artery disease; CRC cis rs936229 0.705 rs936227 chr15:75131959 A/G cg14664628 chr15:75095509 CSK -0.67 -11.29 -0.53 3.47e-25 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); CRC cis rs1552244 0.935 rs4441636 chr3:10083876 G/A cg13047869 chr3:10149882 C3orf24 0.57 7.69 0.39 1.76e-13 Alzheimer's disease; CRC cis rs12802244 1 rs12802244 chr11:47932666 G/A cg20307385 chr11:47447363 PSMC3 -0.51 -6.63 -0.34 1.39e-10 Neuroticism; CRC cis rs4280164 0.551 rs8008406 chr14:24811159 C/T cg07162820 chr14:24837146 NFATC4 -0.41 -6.5 -0.34 3.02e-10 Parent of origin effect on language impairment (paternal); CRC cis rs595982 0.527 rs17272673 chr19:49362992 C/A cg15549821 chr19:49342101 PLEKHA4 -0.58 -6.74 -0.35 7.23e-11 Red cell distribution width; CRC cis rs9858542 0.953 rs9827021 chr3:49514764 C/A cg03060546 chr3:49711283 APEH -0.47 -6.6 -0.34 1.63e-10 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs6831352 1.000 rs6532798 chr4:100054827 C/T cg12011299 chr4:100065546 ADH4 0.53 10.92 0.52 6.76e-24 Alcohol dependence; CRC cis rs875971 0.522 rs2949690 chr7:65483242 C/T cg00343986 chr7:65444356 GUSB -0.58 -8.77 -0.44 9.8e-17 Aortic root size; CRC cis rs10540 0.730 rs61877766 chr11:512973 T/G cg08200582 chr11:442649 ANO9 -0.71 -7.39 -0.38 1.2e-12 Body mass index; CRC cis rs9527 0.535 rs4917999 chr10:104963051 C/G cg15744005 chr10:104629667 AS3MT 0.31 6.14 0.32 2.41e-9 Arsenic metabolism; CRC cis rs11122272 0.735 rs2808586 chr1:231515559 C/T cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.54 -8.11 -0.41 1.04e-14 Hemoglobin concentration; CRC cis rs7811142 0.667 rs3873746 chr7:99935097 G/A cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.61 8.2 0.41 5.46e-15 Platelet count; CRC cis rs3858526 0.727 rs10769353 chr11:5954809 C/T cg02574844 chr11:5959923 NA 0.57 9.18 0.45 5.02e-18 DNA methylation (variation); CRC cis rs3093024 0.595 rs4458654 chr6:167476068 A/C cg07741184 chr6:167504864 NA 0.43 7.35 0.38 1.61e-12 Rheumatoid arthritis; CRC cis rs2204008 0.902 rs11520218 chr12:38223227 G/A cg26384229 chr12:38710491 ALG10B 0.69 9.19 0.45 4.67e-18 Bladder cancer; CRC cis rs1552244 0.872 rs115331527 chr3:10154504 G/A cg16606324 chr3:10149918 C3orf24 0.74 9.82 0.48 3.84e-20 Alzheimer's disease; CRC cis rs853679 0.517 rs4713141 chr6:28101678 G/C cg02631126 chr6:28058918 ZSCAN12L1 0.29 5.89 0.31 9.41e-9 Depression; CRC cis rs514406 0.858 rs574853 chr1:53310959 A/T cg27535305 chr1:53392650 SCP2 -0.37 -6.67 -0.35 1.09e-10 Monocyte count; CRC trans rs916888 0.821 rs415430 chr17:44859144 C/T cg22968622 chr17:43663579 NA -1.2 -15.72 -0.65 6.5e-42 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs8180040 0.620 rs11707736 chr3:47069504 G/T cg02527881 chr3:46936655 PTH1R 0.33 5.64 0.3 3.65e-8 Colorectal cancer; CRC cis rs2243480 0.908 rs55876148 chr7:65379800 G/A cg12463550 chr7:65579703 CRCP 0.69 6.54 0.34 2.39e-10 Diabetic kidney disease; CRC cis rs4253772 0.591 rs6007727 chr22:46650959 G/A cg03482458 chr22:46692211 CN5H6.4;GTSE1 0.46 6.09 0.32 3.1e-9 LDL cholesterol;Cholesterol, total; CRC cis rs599083 0.590 rs661988 chr11:68189251 T/G cg16797656 chr11:68205561 LRP5 0.5 6.89 0.35 2.93e-11 Bone mineral density (spine); CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg01668174 chr2:106810661 UXS1 0.49 6.2 0.32 1.71e-9 Thyroid stimulating hormone; CRC cis rs2952156 0.883 rs907088 chr17:37833567 G/C cg20243544 chr17:37824526 PNMT 0.55 8.95 0.44 2.66e-17 Asthma; CRC cis rs4676482 1.000 rs4676482 chr3:39237190 A/T cg02254461 chr3:39195904 CSRNP1 0.55 6.73 0.35 7.75e-11 Colonoscopy-negative controls vs population controls; CRC cis rs10751667 0.666 rs6597958 chr11:978087 C/T cg06064525 chr11:970664 AP2A2 -0.3 -6.11 -0.32 2.78e-9 Alzheimer's disease (late onset); CRC cis rs7772486 0.682 rs1337840 chr6:146042558 T/C cg23711669 chr6:146136114 FBXO30 -0.65 -10.88 -0.51 9.23e-24 Lobe attachment (rater-scored or self-reported); CRC trans rs10021731 0.645 rs7698524 chr4:115413573 C/T cg25927708 chr2:119603813 EN1 -0.33 -6.1 -0.32 2.96e-9 Optic disc area; CRC cis rs11105298 0.891 rs11105314 chr12:89924559 C/T cg08166232 chr12:89918718 WDR51B;GALNT4 -0.61 -7.71 -0.39 1.54e-13 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; CRC cis rs4731207 0.596 rs7795199 chr7:124578345 C/T cg23710748 chr7:124431027 NA -0.39 -6.19 -0.32 1.79e-9 Cutaneous malignant melanoma; CRC cis rs2249694 0.960 rs7075572 chr10:135404358 T/C cg16964102 chr10:135390573 NA 0.43 7.25 0.37 3.06e-12 Obesity-related traits; CRC trans rs7615952 0.546 rs2979350 chr3:125362215 T/C cg16558177 chr4:4109446 NA -0.56 -6.7 -0.35 8.94e-11 Blood pressure (smoking interaction); CRC cis rs10242455 0.571 rs55830753 chr7:99292222 A/G cg18809830 chr7:99032528 PTCD1 -0.97 -7.55 -0.38 4.31e-13 Blood metabolite levels; CRC cis rs4713118 0.955 rs9468204 chr6:27688809 C/T cg15786705 chr6:28176104 NA 0.48 6.34 0.33 7.69e-10 Parkinson's disease; CRC cis rs4969178 0.896 rs12602206 chr17:76397133 A/G cg20026190 chr17:76395443 PGS1 0.4 6.17 0.32 2.06e-9 HDL cholesterol levels; CRC cis rs514406 0.861 rs12141260 chr1:53300127 C/T cg27535305 chr1:53392650 SCP2 -0.37 -6.75 -0.35 6.77e-11 Monocyte count; CRC cis rs4481887 0.927 rs4244185 chr1:248486913 A/G cg00666640 chr1:248458726 OR2T12 0.46 7.93 0.4 3.55e-14 Common traits (Other); CRC cis rs12431939 0.948 rs12436158 chr14:51669891 G/A cg23942311 chr14:51606299 NA -0.55 -6.29 -0.33 1e-9 Cancer; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg19987288 chr12:56122958 CD63 0.36 6.17 0.32 1.97e-9 Liver disease severity in Alagille syndrome; CRC cis rs7618915 0.508 rs13065851 chr3:52644836 T/A cg18404041 chr3:52824283 ITIH1 -0.43 -8.93 -0.44 2.97e-17 Bipolar disorder; CRC trans rs4263408 0.934 rs9683743 chr4:39703194 A/C cg02970861 chr11:62359288 TUT1 -0.44 -6.48 -0.34 3.26e-10 Plasma amyloid beta peptide concentrations (ABx-40); CRC cis rs6952808 0.771 rs10950415 chr7:1914477 A/G cg00106254 chr7:1943704 MAD1L1 -0.41 -6.46 -0.34 3.76e-10 Bipolar disorder and schizophrenia; CRC cis rs9814567 1.000 rs6772896 chr3:134203347 C/T cg06109529 chr3:134205091 CEP63;ANAPC13 -0.82 -12.24 -0.56 1.22e-28 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs1799949 1.000 rs1799966 chr17:41223094 T/C cg05368731 chr17:41323189 NBR1 0.68 10.27 0.49 1.19e-21 Menopause (age at onset); CRC cis rs6461049 0.734 rs1558465 chr7:2151398 G/C cg21782813 chr7:2030301 MAD1L1 0.46 8.42 0.42 1.15e-15 Schizophrenia; CRC cis rs13256369 0.802 rs11249885 chr8:8562008 C/T cg06671706 chr8:8559999 CLDN23 0.52 7.63 0.39 2.56e-13 Obesity-related traits; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg02664664 chr10:72163983 EIF4EBP2 0.43 6.77 0.35 5.95e-11 Liver disease severity in Alagille syndrome; CRC cis rs938554 0.784 rs13102218 chr4:9976113 G/T cg11266682 chr4:10021025 SLC2A9 0.35 5.64 0.3 3.62e-8 Blood metabolite levels; CRC cis rs12908161 1.000 rs12899981 chr15:85302373 G/A cg17507749 chr15:85114479 UBE2QP1 0.62 8.97 0.44 2.36e-17 Schizophrenia; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg03509671 chr3:101497876 FAM55C 0.39 6.51 0.34 2.87e-10 Liver disease severity in Alagille syndrome; CRC cis rs7493 1.000 rs17166875 chr7:95041271 C/T cg19678392 chr7:94953810 PON1 -0.56 -7.07 -0.36 9.28e-12 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs873946 0.586 rs36084869 chr10:134566069 G/A cg06453172 chr10:134556979 INPP5A -0.69 -8.23 -0.41 4.32e-15 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CRC cis rs13217239 0.646 rs10456351 chr6:26986792 C/T cg18867708 chr6:26865862 GUSBL1 0.38 5.82 0.31 1.39e-8 Schizophrenia; CRC cis rs1799949 1.000 rs11655505 chr17:41278377 G/A cg05368731 chr17:41323189 NBR1 0.69 10.48 0.5 2.22e-22 Menopause (age at onset); CRC cis rs1957429 0.901 rs17102320 chr14:65384693 T/C cg23373153 chr14:65346875 NA -0.82 -8.53 -0.43 5.26e-16 Pediatric areal bone mineral density (radius); CRC cis rs72615157 0.697 rs2056726 chr7:99780283 G/A cg13153964 chr7:100026424 MEPCE;ZCWPW1 0.77 9.23 0.45 3.32e-18 Lung function (FEV1/FVC); CRC cis rs2050392 0.517 rs656600 chr10:30765654 G/A cg25182066 chr10:30743637 MAP3K8 -0.62 -8.75 -0.43 1.1e-16 Inflammatory bowel disease; CRC cis rs17826219 0.500 rs28452421 chr17:29083980 G/A cg01831904 chr17:28903510 LRRC37B2 -0.63 -6.45 -0.33 4.07e-10 Body mass index; CRC trans rs1005277 0.522 rs11011343 chr10:38002698 A/G cg17830980 chr10:43048298 ZNF37B -0.4 -6.16 -0.32 2.12e-9 Extrinsic epigenetic age acceleration; CRC cis rs6500602 0.592 rs7206782 chr16:4515145 A/C cg06139259 chr16:4526053 HMOX2;NMRAL1 0.48 6.25 0.33 1.26e-9 Schizophrenia; CRC cis rs10504229 0.773 rs1874373 chr8:58194423 T/C cg02290350 chr8:58132656 NA -0.45 -6.57 -0.34 1.99e-10 Developmental language disorder (linguistic errors); CRC cis rs473651 0.967 rs483042 chr2:239335320 A/G cg18131467 chr2:239335373 ASB1 1.03 23.5 0.79 2.21e-72 Multiple system atrophy; CRC cis rs3087591 1.000 rs2051507 chr17:29700101 A/G cg24425628 chr17:29625626 OMG;NF1 -0.84 -16.34 -0.67 2.32e-44 Hip circumference; CRC cis rs7666738 0.830 rs880470 chr4:98922522 A/T cg17366294 chr4:99064904 C4orf37 0.43 7.32 0.37 1.95e-12 Colonoscopy-negative controls vs population controls; CRC cis rs1552244 0.572 rs3894322 chr3:10168965 G/A cg08888203 chr3:10149979 C3orf24 0.71 8.58 0.43 3.91e-16 Alzheimer's disease; CRC trans rs11252926 0.797 rs61837235 chr10:489363 G/A cg00953403 chr17:74099816 EXOC7 -0.49 -6.67 -0.35 1.08e-10 Psychosis in Alzheimer's disease; CRC cis rs4268898 0.722 rs4665253 chr2:24382546 G/A cg06627628 chr2:24431161 ITSN2 0.46 6.79 0.35 5.3e-11 Asthma; CRC cis rs7914558 0.966 rs7096269 chr10:104736721 A/G cg15744005 chr10:104629667 AS3MT -0.34 -7.43 -0.38 9.16e-13 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg24543526 chr10:75911479 ADK;AP3M1 0.41 5.98 0.31 5.7e-9 Intelligence (multi-trait analysis); CRC cis rs10256972 0.552 rs2960831 chr7:1201192 A/T cg07092213 chr7:1199455 ZFAND2A -0.49 -7.1 -0.36 7.72e-12 Longevity;Endometriosis; CRC cis rs736408 0.570 rs11130327 chr3:52793239 A/G cg18099408 chr3:52552593 STAB1 -0.45 -7.2 -0.37 4.22e-12 Bipolar disorder; CRC cis rs6694672 1.000 rs6680497 chr1:197083329 G/A cg13682187 chr1:196946512 CFHR5 0.47 7.63 0.39 2.49e-13 Asthma; CRC cis rs736408 0.648 rs3774355 chr3:52817778 G/A cg07507251 chr3:52567010 NT5DC2 0.48 6.64 0.34 1.29e-10 Bipolar disorder; CRC trans rs3806843 0.712 rs2530244 chr5:140109155 A/G cg06840491 chr10:48416966 GDF2 -0.35 -6.07 -0.32 3.45e-9 Depressive symptoms (multi-trait analysis); CRC cis rs11122272 0.735 rs1416916 chr1:231533027 A/G cg06096015 chr1:231504339 EGLN1 0.4 6.0 0.31 5.13e-9 Hemoglobin concentration; CRC cis rs10751667 0.621 rs10794353 chr11:948740 A/G cg01483505 chr11:975446 AP2A2 0.42 6.83 0.35 4.1e-11 Alzheimer's disease (late onset); CRC cis rs2839186 0.872 rs13052495 chr21:47707474 G/A cg02776659 chr21:47717406 C21orf57 -0.34 -5.62 -0.3 4.13e-8 Testicular germ cell tumor; CRC cis rs9914988 0.832 rs11650788 chr17:27174523 T/A cg16670446 chr17:27188758 MIR451;MIR144 0.6 9.71 0.47 9.02e-20 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg04152460 chr6:28109974 ZNF192 0.42 6.04 0.32 4.25e-9 Intelligence (multi-trait analysis); CRC cis rs763014 1.000 rs7205409 chr16:642610 A/G cg00908189 chr16:619842 PIGQ 0.63 10.38 0.5 4.96e-22 Height; CRC cis rs10504229 0.683 rs72650847 chr8:58136825 C/T cg11062466 chr8:58055876 NA 0.56 6.92 0.36 2.37e-11 Developmental language disorder (linguistic errors); CRC cis rs3008870 1.000 rs3008871 chr1:67419089 A/G cg08660285 chr1:67390436 MIER1;WDR78 -1.01 -14.75 -0.63 3.79e-38 Lymphocyte percentage of white cells; CRC trans rs35110281 0.591 rs162366 chr21:44935383 C/T cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO -0.49 -8.1 -0.41 1.11e-14 Mean corpuscular volume; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg18123596 chr17:36956264 PIP4K2B 0.43 6.06 0.32 3.73e-9 Response to antipsychotic treatment; CRC cis rs6712932 1.000 rs6712932 chr2:105837598 C/T cg27422857 chr2:105853526 NA 0.3 5.68 0.3 2.94e-8 Type 2 diabetes; CRC cis rs4716602 0.596 rs1996994 chr7:156159694 A/G cg16983916 chr7:156159713 NA 0.39 6.81 0.35 4.59e-11 Anti-saccade response; CRC cis rs11622475 1.000 rs10136440 chr14:104397367 C/A cg12183467 chr14:104352244 NA 0.49 6.8 0.35 4.86e-11 Bipolar disorder; CRC cis rs992157 0.764 rs2891079 chr2:219184691 A/G cg04880052 chr2:219191631 PNKD 0.4 6.03 0.32 4.48e-9 Colorectal cancer; CRC cis rs7072216 0.666 rs2274248 chr10:100148542 C/T cg26618903 chr10:100175079 PYROXD2 -0.37 -5.73 -0.3 2.22e-8 Metabolite levels; CRC cis rs9325144 0.560 rs10785573 chr12:38654166 G/A cg13010199 chr12:38710504 ALG10B -0.42 -6.12 -0.32 2.7e-9 Morning vs. evening chronotype; CRC cis rs3806843 0.517 rs246031 chr5:140333107 G/A cg19875535 chr5:140030758 IK 0.4 6.12 0.32 2.64e-9 Depressive symptoms (multi-trait analysis); CRC cis rs354225 0.546 rs10170646 chr2:54799606 T/C cg26097391 chr2:54893211 SPTBN1 0.49 8.46 0.42 9.01e-16 Schizophrenia; CRC cis rs11098499 0.754 rs11724409 chr4:120252361 A/G cg09307838 chr4:120376055 NA 0.61 9.59 0.47 2.22e-19 Corneal astigmatism; CRC cis rs10504229 1.000 rs73607871 chr8:58173007 T/C cg02290350 chr8:58132656 NA -0.42 -5.96 -0.31 6.62e-9 Developmental language disorder (linguistic errors); CRC cis rs4713118 0.588 rs200994 chr6:27813813 A/C cg26587870 chr6:27730563 NA 0.44 6.25 0.33 1.27e-9 Parkinson's disease; CRC cis rs13191362 0.935 rs7763118 chr6:162954720 A/G cg06582575 chr6:163149167 PACRG;PARK2 0.78 9.96 0.48 1.31e-20 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs4604732 0.536 rs76191272 chr1:247628055 A/T cg12758973 chr1:247694275 LOC148824;OR2C3 0.38 5.75 0.3 2.03e-8 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CRC cis rs832540 0.931 rs832534 chr5:56213672 G/A cg18230493 chr5:56204884 C5orf35 -0.4 -5.87 -0.31 1.05e-8 Coronary artery disease; CRC cis rs9814567 1.000 rs7648990 chr3:134244390 T/G cg06541857 chr3:134203789 ANAPC13;CEP63 -0.4 -6.12 -0.32 2.65e-9 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs367615 0.506 rs2914684 chr5:108775110 C/T cg17395555 chr5:108820864 NA -0.39 -7.68 -0.39 1.84e-13 Colorectal cancer (SNP x SNP interaction); CRC cis rs4665809 0.531 rs34081866 chr2:26475940 C/T cg26119090 chr2:26468346 HADHA;HADHB 1.0 14.61 0.63 1.33e-37 Gut microbiome composition (summer); CRC cis rs798554 0.757 rs1182171 chr7:2878510 A/G cg13628971 chr7:2884303 GNA12 0.48 6.53 0.34 2.43e-10 Height; CRC cis rs10739663 0.520 rs13294786 chr9:128156961 A/G cg14078157 chr9:128172775 NA -0.34 -5.67 -0.3 3.17e-8 Resting heart rate; CRC cis rs4664293 0.867 rs6432560 chr2:160607269 G/C cg08347373 chr2:160653686 CD302 -0.47 -7.43 -0.38 9.32e-13 Monocyte percentage of white cells; CRC cis rs9527 0.590 rs12355120 chr10:104852166 T/G cg15744005 chr10:104629667 AS3MT -0.31 -6.24 -0.33 1.34e-9 Arsenic metabolism; CRC cis rs1129187 0.755 rs9471988 chr6:42944773 T/C cg09436375 chr6:42928200 GNMT -0.34 -6.34 -0.33 7.71e-10 Alzheimer's disease in APOE e4+ carriers; CRC cis rs3858526 0.628 rs4237762 chr11:5956626 A/C cg05234568 chr11:5960015 NA -0.7 -11.34 -0.53 2.2e-25 DNA methylation (variation); CRC cis rs739401 0.595 rs6578305 chr11:3001120 C/T cg08508325 chr11:3079039 CARS -0.43 -7.66 -0.39 2.07e-13 Longevity; CRC cis rs1023500 0.573 rs13057094 chr22:42470317 T/C cg15557168 chr22:42548783 NA -0.36 -5.92 -0.31 8.2e-9 Schizophrenia; CRC cis rs870825 0.616 rs7694899 chr4:185625390 C/T cg04058563 chr4:185651563 MLF1IP 0.7 9.2 0.45 4.31e-18 Blood protein levels; CRC cis rs7927771 0.864 rs3781626 chr11:47442893 A/T cg20307385 chr11:47447363 PSMC3 -0.58 -8.67 -0.43 2e-16 Subjective well-being; CRC cis rs9733 0.596 rs11204704 chr1:150671630 T/C cg18016565 chr1:150552671 MCL1 0.46 6.69 0.35 9.85e-11 Tonsillectomy; CRC cis rs3824867 0.804 rs12419342 chr11:47468545 C/T cg20307385 chr11:47447363 PSMC3 0.46 5.85 0.31 1.19e-8 Mean corpuscular hemoglobin; CRC cis rs9611565 0.649 rs738422 chr22:42123399 C/T cg03806693 chr22:41940476 POLR3H 0.67 9.45 0.46 6.78e-19 Vitiligo; CRC cis rs10751667 0.961 rs10902263 chr11:992691 A/C ch.11.42038R chr11:967971 AP2A2 -0.7 -11.72 -0.54 9.48e-27 Alzheimer's disease (late onset); CRC cis rs3806843 0.966 rs12659129 chr5:140147248 T/C cg19875535 chr5:140030758 IK 0.55 8.77 0.44 9.72e-17 Depressive symptoms (multi-trait analysis); CRC cis rs7666738 0.791 rs6828752 chr4:99063382 C/T cg17366294 chr4:99064904 C4orf37 0.44 7.47 0.38 7.31e-13 Colonoscopy-negative controls vs population controls; CRC cis rs801193 0.591 rs2707839 chr7:66193084 A/G cg00343986 chr7:65444356 GUSB 0.43 6.12 0.32 2.63e-9 Aortic root size; CRC cis rs1552244 0.816 rs13076197 chr3:10019773 T/C cg02579736 chr3:10068473 FANCD2;CIDECP 0.93 11.94 0.55 1.55e-27 Alzheimer's disease; CRC cis rs2952156 0.883 rs2941505 chr17:37832704 A/G cg20243544 chr17:37824526 PNMT 0.55 8.87 0.44 4.67e-17 Asthma; CRC cis rs6701037 0.566 rs1883102 chr1:175136793 T/A cg00321850 chr1:175162397 KIAA0040 0.44 7.45 0.38 8.38e-13 Alcohol dependence; CRC cis rs2179367 0.959 rs2262617 chr6:149759726 C/G cg07828024 chr6:149772892 ZC3H12D -0.38 -6.31 -0.33 9.19e-10 Dupuytren's disease; CRC cis rs13191362 1.000 rs34725898 chr6:163127302 C/T cg06582575 chr6:163149167 PACRG;PARK2 0.92 11.96 0.55 1.34e-27 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg10620530 chr9:139922595 C9orf139;ABCA2 0.45 6.33 0.33 8.18e-10 Response to antipsychotic treatment; CRC cis rs16867321 0.950 rs12477283 chr2:181501355 G/T cg23363182 chr2:181467187 NA -0.51 -6.59 -0.34 1.72e-10 Obesity; CRC cis rs9491140 0.539 rs10457447 chr6:124698568 A/C cg22366943 chr6:124882293 NKAIN2 -0.55 -6.87 -0.35 3.15e-11 Neuroticism; CRC cis rs17270561 0.636 rs1185977 chr6:25829054 A/G cg17691542 chr6:26056736 HIST1H1C 0.54 7.72 0.39 1.41e-13 Iron status biomarkers; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg01117833 chr14:94547303 DDX24;IFI27L1 0.41 6.46 0.34 3.77e-10 Liver disease severity in Alagille syndrome; CRC cis rs12681287 0.640 rs10098356 chr8:87442667 A/G cg27223183 chr8:87520930 FAM82B 0.52 7.36 0.38 1.45e-12 Caudate activity during reward; CRC cis rs2976388 0.578 rs13254358 chr8:143823876 G/A cg20041105 chr8:143859282 LYNX1 -0.42 -6.55 -0.34 2.28e-10 Urinary tract infection frequency; CRC cis rs2404602 0.716 rs1874944 chr15:76863928 A/G cg23625390 chr15:77176239 SCAPER 0.47 6.85 0.35 3.61e-11 Blood metabolite levels; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg23240857 chr4:140005776 ELF2 0.48 6.99 0.36 1.52e-11 Response to antipsychotic treatment; CRC trans rs6600671 0.934 rs67718113 chr1:121238910 C/T cg00646200 chr1:148855367 NA -0.34 -6.07 -0.32 3.45e-9 Hip geometry; CRC trans rs2464469 0.654 rs4646570 chr15:58343146 G/C cg12066864 chr14:32672656 NA 0.41 6.1 0.32 3.01e-9 Barrett's esophagus or Esophageal adenocarcinoma; CRC cis rs713587 0.563 rs2384057 chr2:25100167 C/G cg04586622 chr2:25135609 ADCY3 -0.57 -10.46 -0.5 2.65e-22 Body mass index in non-asthmatics; CRC cis rs11971779 0.680 rs6961812 chr7:139043808 A/C cg23387468 chr7:139079360 LUC7L2 0.41 7.04 0.36 1.14e-11 Diisocyanate-induced asthma; CRC cis rs2346177 0.875 rs2881327 chr2:46641955 A/G cg26688816 chr2:46740690 ATP6V1E2 -0.51 -8.4 -0.42 1.36e-15 HDL cholesterol; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg25261059 chr19:44031185 ETHE1 -0.42 -6.18 -0.32 1.87e-9 Myopia (pathological); CRC cis rs1552244 0.938 rs34750074 chr3:10091740 G/A cg18598329 chr3:10140678 FANCD2;C3orf24 -0.88 -11.83 -0.55 3.83e-27 Alzheimer's disease; CRC cis rs798554 0.679 rs7807978 chr7:2814635 C/T cg13628971 chr7:2884303 GNA12 0.43 6.62 0.34 1.43e-10 Height; CRC cis rs7412746 0.587 rs11204722 chr1:150730184 A/C cg10589385 chr1:150898437 SETDB1 -0.28 -5.7 -0.3 2.65e-8 Melanoma; CRC cis rs1059312 1.000 rs7135987 chr12:129280117 G/A cg09035930 chr12:129282057 SLC15A4 0.55 9.26 0.45 2.68e-18 Systemic lupus erythematosus; CRC cis rs950169 0.724 rs11632668 chr15:84948687 T/C cg17507749 chr15:85114479 UBE2QP1 0.74 10.55 0.5 1.32e-22 Schizophrenia; CRC trans rs12310956 0.515 rs1872745 chr12:33985987 G/A cg26384229 chr12:38710491 ALG10B 0.47 6.28 0.33 1.06e-9 Morning vs. evening chronotype; CRC cis rs2204008 0.546 rs11519978 chr12:37998170 C/T cg26384229 chr12:38710491 ALG10B 0.68 8.93 0.44 3.1e-17 Bladder cancer; CRC cis rs9467711 0.606 rs1978 chr6:26377573 A/T cg16898833 chr6:26189333 HIST1H4D 0.78 6.28 0.33 1.04e-9 Autism spectrum disorder or schizophrenia; CRC cis rs9903692 0.954 rs8076380 chr17:46190390 G/A cg21215337 chr17:46176117 CBX1 -0.42 -7.91 -0.4 4e-14 Pulse pressure; CRC cis rs10927875 0.722 rs1763605 chr1:16338925 T/G cg21385522 chr1:16154831 NA 0.61 7.68 0.39 1.85e-13 Dilated cardiomyopathy; CRC cis rs875971 1.000 rs6957199 chr7:65978519 T/C cg12463550 chr7:65579703 CRCP 0.47 6.75 0.35 6.49e-11 Aortic root size; CRC cis rs12760731 0.720 rs16852801 chr1:178403134 A/T cg00404053 chr1:178313656 RASAL2 -0.88 -9.38 -0.46 1.14e-18 Obesity-related traits; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg13928594 chr12:110562699 IFT81 0.49 6.43 0.33 4.55e-10 Thyroid stimulating hormone; CRC cis rs9309473 0.848 rs17009159 chr2:73797762 A/T cg20560298 chr2:73613845 ALMS1 -0.47 -5.81 -0.3 1.5e-8 Metabolite levels; CRC cis rs4466137 0.553 rs16898 chr5:82986149 T/C cg15083037 chr5:83017644 HAPLN1 -0.42 -6.46 -0.34 3.69e-10 Prostate cancer; CRC trans rs2814331 0.607 rs1902678 chr10:88006634 C/G cg16062483 chr14:98444417 C14orf64 0.66 6.07 0.32 3.5e-9 Balding; CRC cis rs2992756 0.663 rs2992755 chr1:18807897 C/G cg14356550 chr1:18808102 KLHDC7A -0.38 -5.69 -0.3 2.83e-8 Breast cancer; CRC cis rs908922 0.584 rs71626721 chr1:152532745 A/G cg09873164 chr1:152488093 CRCT1 0.37 6.29 0.33 9.94e-10 Hair morphology; CRC trans rs1814175 0.615 rs4545557 chr11:50027329 A/C cg15704280 chr7:45808275 SEPT13 -0.92 -16.92 -0.68 1.2e-46 Height; CRC cis rs2115630 0.645 rs6496284 chr15:85178270 A/G cg11189052 chr15:85197271 WDR73 -0.69 -11.7 -0.54 1.14e-26 P wave terminal force; CRC cis rs2739330 0.760 rs5751760 chr22:24243573 G/A cg11905131 chr22:24372483 LOC391322 -0.67 -10.45 -0.5 2.8e-22 Liver enzyme levels (gamma-glutamyl transferase); CRC trans rs492478 0.892 rs11952713 chr5:3942942 G/T cg09199442 chr11:28132951 METT5D1 -0.71 -6.24 -0.33 1.36e-9 Cognitive performance; CRC cis rs12541635 0.934 rs2029882 chr8:107022894 G/A cg10147462 chr8:107024639 NA 0.44 7.29 0.37 2.38e-12 Age of smoking initiation; CRC cis rs7567389 0.740 rs1604817 chr2:127999921 C/T cg09760422 chr2:128146352 NA -0.4 -7.68 -0.39 1.79e-13 Self-rated health; CRC cis rs4711336 0.633 rs9469583 chr6:33717770 T/C cg14003231 chr6:33640908 ITPR3 0.37 5.87 0.31 1.04e-8 Height; CRC cis rs1552244 1.000 rs66838678 chr3:10150350 G/A cg00166722 chr3:10149974 C3orf24 0.69 9.16 0.45 5.63e-18 Alzheimer's disease; CRC cis rs2204008 0.713 rs11173567 chr12:38089375 T/C cg13010199 chr12:38710504 ALG10B 0.44 5.79 0.3 1.61e-8 Bladder cancer; CRC cis rs4242434 0.757 rs7005025 chr8:22519815 G/T cg03733263 chr8:22462867 KIAA1967 0.84 14.48 0.62 4.09e-37 Exploratory eye movement dysfunction in schizophrenia (cognitive search score); CRC cis rs6951245 0.938 rs78351779 chr7:1097023 G/C cg24642844 chr7:1081250 C7orf50 -0.78 -9.44 -0.46 7.23e-19 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC trans rs1907989 1.000 rs2172443 chr4:4819565 A/G cg24061105 chr18:77125858 ATP9B -0.39 -5.98 -0.31 5.66e-9 Nonsyndromic cleft lip with cleft palate; CRC cis rs6912958 1.000 rs2223880 chr6:88167897 C/T cg12350822 chr6:88032061 C6orf162;GJB7 -0.42 -8.11 -0.41 9.9e-15 Monocyte percentage of white cells; CRC cis rs938554 0.784 rs16868246 chr4:9978305 C/G cg11266682 chr4:10021025 SLC2A9 0.35 5.62 0.3 4.17e-8 Blood metabolite levels; CRC cis rs853679 0.517 rs4713152 chr6:28137454 G/A cg23161317 chr6:28129485 ZNF389 0.53 6.43 0.33 4.52e-10 Depression; CRC cis rs9381040 0.655 rs9394756 chr6:41016183 A/G cg09580153 chr6:41068724 NFYA;LOC221442 -0.44 -6.42 -0.33 4.79e-10 Alzheimer's disease (late onset); CRC cis rs7772486 0.720 rs991507 chr6:146023609 G/A cg13319975 chr6:146136371 FBXO30 0.46 6.79 0.35 5.29e-11 Lobe attachment (rater-scored or self-reported); CRC cis rs758324 0.947 rs804059 chr5:131270136 T/C cg06307176 chr5:131281290 NA -0.42 -6.32 -0.33 8.63e-10 Alzheimer's disease in APOE e4- carriers; CRC cis rs6499255 0.951 rs7198242 chr16:69648495 C/T cg05250797 chr16:70222502 NA -0.4 -5.63 -0.3 3.94e-8 IgE levels; CRC cis rs7680126 0.626 rs11721501 chr4:10189135 G/A cg11266682 chr4:10021025 SLC2A9 -0.47 -6.67 -0.35 1.09e-10 Urate levels in lean individuals;Urate levels in overweight individuals;Urate levels in obese individuals; CRC trans rs10982213 0.830 rs2274163 chr9:117188714 C/T cg07116851 chr12:58146173 CDK4 0.38 6.08 0.32 3.3e-9 Interleukin-6 levels; CRC cis rs35110281 0.565 rs7278003 chr21:44966069 T/C cg01579765 chr21:45077557 HSF2BP -0.35 -6.43 -0.33 4.56e-10 Mean corpuscular volume; CRC cis rs12024301 0.557 rs12045762 chr1:183617413 T/C cg11505048 chr1:183622726 RGL1;APOBEC4 0.81 7.0 0.36 1.42e-11 Peripheral arterial disease (traffic-related air pollution interaction); CRC trans rs7647973 0.626 rs4855882 chr3:49715354 G/T cg21659725 chr3:3221576 CRBN -0.61 -6.29 -0.33 1.01e-9 Menarche (age at onset); CRC cis rs4713118 0.869 rs9461405 chr6:27719375 G/T cg03623178 chr6:28175578 NA 0.67 9.51 0.46 4.27e-19 Parkinson's disease; CRC cis rs910187 0.605 rs3787235 chr20:45803522 C/T cg27589058 chr20:45804311 EYA2 -0.42 -8.44 -0.42 9.92e-16 Migraine; CRC cis rs950169 0.579 rs62027818 chr15:84661145 T/C cg17507749 chr15:85114479 UBE2QP1 0.63 8.5 0.42 6.83e-16 Schizophrenia; CRC cis rs7412746 0.658 rs6669855 chr1:150861229 C/T cg17724175 chr1:150552817 MCL1 0.48 7.09 0.36 7.99e-12 Melanoma; CRC cis rs6502050 0.835 rs8075086 chr17:80092649 A/G cg02741985 chr17:80059408 CCDC57 0.43 7.11 0.36 7.35e-12 Life satisfaction; CRC trans rs11992162 0.636 rs11250182 chr8:11807576 A/T cg06636001 chr8:8085503 FLJ10661 -0.41 -6.33 -0.33 8.23e-10 Monocyte count; CRC trans rs875033 0.690 rs856835 chr6:68293485 C/T cg00112309 chr8:106787982 ZFPM2 -0.41 -6.0 -0.31 5.17e-9 Response to amphetamines; CRC cis rs13108904 0.934 rs13149952 chr4:1308437 C/G cg02018176 chr4:1364513 KIAA1530 0.44 7.1 0.36 7.52e-12 Obesity-related traits; CRC cis rs12586317 0.534 rs2273157 chr14:35438836 A/G cg05294307 chr14:35346193 BAZ1A -0.69 -8.82 -0.44 6.97e-17 Psoriasis; CRC cis rs1524976 1.000 rs62255276 chr3:65457776 C/A cg16238336 chr3:65465873 MAGI1 -0.53 -7.56 -0.38 4.08e-13 PR interval; CRC cis rs7666738 1.000 rs880471 chr4:98922541 C/T cg17366294 chr4:99064904 C4orf37 0.47 7.58 0.39 3.53e-13 Colonoscopy-negative controls vs population controls; CRC cis rs1129187 0.755 rs2274517 chr6:42932715 A/G cg05552183 chr6:42928497 GNMT -0.54 -8.49 -0.42 7.45e-16 Alzheimer's disease in APOE e4+ carriers; CRC cis rs6500395 0.928 rs4785532 chr16:48695500 G/A cg04672837 chr16:48644449 N4BP1 -0.45 -6.63 -0.34 1.38e-10 Response to tocilizumab in rheumatoid arthritis; CRC cis rs10504229 1.000 rs6989060 chr8:58178989 T/G cg01721255 chr8:58191610 C8orf71 0.49 6.17 0.32 2e-9 Developmental language disorder (linguistic errors); CRC cis rs7647973 1.000 rs1009051 chr3:49521549 G/A cg20833759 chr3:49053208 WDR6;DALRD3 0.55 8.47 0.42 8.41e-16 Menarche (age at onset); CRC cis rs7208859 0.623 rs7220999 chr17:29149298 C/T cg13385521 chr17:29058706 SUZ12P 0.74 8.22 0.41 4.85e-15 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg23901904 chr1:10855062 CASZ1 0.46 6.54 0.34 2.3e-10 Response to antipsychotic treatment; CRC cis rs9648716 0.554 rs10235900 chr7:140601438 G/T cg10747023 chr7:140774559 NA 0.46 6.32 0.33 8.29e-10 Type 2 diabetes; CRC cis rs10504229 0.679 rs12375285 chr8:58040084 G/A cg02290350 chr8:58132656 NA -0.43 -5.64 -0.3 3.68e-8 Developmental language disorder (linguistic errors); CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg13632070 chr5:79552065 SERINC5 0.46 6.27 0.33 1.15e-9 Anxiety disorder; CRC cis rs10493773 0.566 rs11161659 chr1:86183967 T/C cg00734567 chr1:86172782 ZNHIT6 -0.48 -7.38 -0.38 1.33e-12 Urate levels in overweight individuals; CRC cis rs881375 0.933 rs1548784 chr9:123685280 T/C cg09419670 chr9:123605666 PSMD5;LOC253039 0.56 8.29 0.42 3.01e-15 Rheumatoid arthritis; CRC cis rs1799949 1.000 rs11079056 chr17:41300799 C/A cg05368731 chr17:41323189 NBR1 0.69 10.5 0.5 1.94e-22 Menopause (age at onset); CRC cis rs7666738 0.544 rs35160902 chr4:98974690 A/T cg17366294 chr4:99064904 C4orf37 0.43 7.28 0.37 2.47e-12 Colonoscopy-negative controls vs population controls; CRC cis rs10751667 0.666 rs7395488 chr11:954111 T/C cg01483505 chr11:975446 AP2A2 0.45 7.44 0.38 9.1e-13 Alzheimer's disease (late onset); CRC cis rs2933343 0.700 rs1683779 chr3:128642048 A/G cg11901034 chr3:128598214 ACAD9 -0.55 -7.91 -0.4 4.03e-14 IgG glycosylation; CRC cis rs938554 0.571 rs12509955 chr4:10024303 C/T cg00071950 chr4:10020882 SLC2A9 -0.54 -8.02 -0.4 1.89e-14 Blood metabolite levels; CRC cis rs1046896 0.520 rs9895409 chr17:80902719 C/T cg17346650 chr17:80929145 B3GNTL1 0.49 7.46 0.38 7.71e-13 Glycated hemoglobin levels; CRC cis rs2645694 0.626 rs2645704 chr4:77830805 T/C cg18351406 chr4:77819688 ANKRD56 0.5 7.58 0.39 3.58e-13 Emphysema distribution in smoking; CRC cis rs10504073 0.669 rs11779189 chr8:50030592 C/G cg00325661 chr8:49890786 NA -0.39 -6.97 -0.36 1.72e-11 Blood metabolite ratios; CRC cis rs6460942 0.544 rs73287153 chr7:12139272 A/G cg06484146 chr7:12443880 VWDE -0.51 -6.1 -0.32 3.04e-9 Coronary artery disease; CRC cis rs72717009 0.825 rs7529425 chr1:161479599 G/A cg15358701 chr1:161410459 NA -0.61 -6.57 -0.34 2.02e-10 Rheumatoid arthritis; CRC cis rs7208859 0.623 rs1054400 chr17:29109954 A/G cg01831904 chr17:28903510 LRRC37B2 -0.63 -6.45 -0.33 4.07e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs561341 0.883 rs1034626 chr17:30219500 C/G cg12193833 chr17:30244370 NA 0.57 7.29 0.37 2.26e-12 Hip circumference adjusted for BMI; CRC cis rs243505 0.898 rs243524 chr7:148418181 A/C cg09806900 chr7:148480153 CUL1 -0.4 -5.79 -0.3 1.68e-8 Inflammatory bowel disease;Crohn's disease; CRC cis rs9517320 0.534 rs912330 chr13:99131294 C/T cg20487152 chr13:99095054 FARP1 -0.43 -6.25 -0.33 1.28e-9 Longevity; CRC cis rs72945132 0.882 rs67529561 chr11:70162055 G/T cg00319359 chr11:70116639 PPFIA1 0.67 7.46 0.38 7.95e-13 Coronary artery disease; CRC trans rs634534 0.622 rs552130 chr11:65732800 T/C cg17712092 chr4:129076599 LARP1B 0.61 9.97 0.48 1.26e-20 Sum eosinophil basophil counts;Eosinophil counts; CRC cis rs362272 0.545 rs3129308 chr4:3309272 C/T cg16416165 chr4:3325029 RGS12 0.38 5.71 0.3 2.47e-8 Serum sulfate level; CRC trans rs10842750 1.000 rs10842750 chr12:26690565 G/T cg15190599 chr6:26156487 HIST1H1E 0.49 6.03 0.32 4.3e-9 Kashin-Beck disease; CRC cis rs2067615 0.579 rs1073261 chr12:107135942 A/G cg13491945 chr12:107078410 RFX4 0.34 5.86 0.31 1.09e-8 Heart rate; CRC cis rs7727544 0.507 rs11741341 chr5:131570218 A/G cg18758796 chr5:131593413 PDLIM4 0.47 8.4 0.42 1.37e-15 Blood metabolite levels; CRC cis rs9969804 0.782 rs10761170 chr9:95529203 A/G cg14631576 chr9:95140430 CENPP -0.32 -5.91 -0.31 8.56e-9 Height; CRC cis rs72945132 0.882 rs17853270 chr11:70200529 C/T cg00319359 chr11:70116639 PPFIA1 0.62 6.6 0.34 1.61e-10 Coronary artery disease; CRC cis rs4819052 0.766 rs4819035 chr21:46645715 A/C cg11663144 chr21:46675770 NA -0.64 -8.7 -0.43 1.59e-16 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs1862618 0.853 rs6450408 chr5:56098146 T/C cg24531977 chr5:56204891 C5orf35 -0.85 -11.37 -0.53 1.74e-25 Initial pursuit acceleration; CRC cis rs12926788 0.640 rs73551577 chr16:24845143 G/A cg02428538 chr16:24856791 SLC5A11 -0.57 -6.74 -0.35 7.08e-11 Ejection fraction in Tripanosoma cruzi seropositivity; CRC cis rs9287719 0.967 rs7593496 chr2:10738176 A/C cg00105475 chr2:10696890 NA 0.45 7.3 0.37 2.19e-12 Prostate cancer; CRC cis rs9911578 0.740 rs368243 chr17:56708979 T/C cg05425664 chr17:57184151 TRIM37 -0.41 -6.24 -0.33 1.35e-9 Intelligence (multi-trait analysis); CRC cis rs8036030 0.604 rs11852686 chr15:74715205 A/G cg10253484 chr15:75165896 SCAMP2 -0.43 -6.2 -0.32 1.67e-9 Airflow obstruction; CRC cis rs11190604 1.000 rs11190551 chr10:102204734 A/G cg07080220 chr10:102295463 HIF1AN 0.47 5.79 0.3 1.63e-8 Palmitoleic acid (16:1n-7) levels; CRC cis rs7618915 0.547 rs10865973 chr3:52718154 A/T cg11645453 chr3:52864694 ITIH4 0.37 6.41 0.33 4.91e-10 Bipolar disorder; CRC cis rs2882667 0.898 rs2043272 chr5:138390631 A/C cg04439458 chr5:138467593 SIL1 -0.36 -6.47 -0.34 3.61e-10 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs7647973 1.000 rs7613491 chr3:49508976 T/C cg07636037 chr3:49044803 WDR6 -0.64 -7.38 -0.38 1.26e-12 Menarche (age at onset); CRC cis rs7666738 0.830 rs3896704 chr4:99034252 C/T cg05340658 chr4:99064831 C4orf37 0.61 9.42 0.46 8.23e-19 Colonoscopy-negative controls vs population controls; CRC cis rs6484504 0.576 rs438578 chr11:31222579 A/G cg14844989 chr11:31128820 NA 0.34 5.98 0.31 5.66e-9 Red blood cell count; CRC cis rs2535633 0.631 rs2581819 chr3:53016552 C/A cg05573699 chr3:52720067 GNL3;PBRM1 0.4 5.88 0.31 1.03e-8 Body mass index; CRC trans rs10242455 1.000 rs73395557 chr7:98934424 C/A cg09045935 chr12:6379348 NA 0.73 6.83 0.35 4e-11 Blood metabolite levels; CRC cis rs6500602 0.929 rs9926114 chr16:4478322 C/G cg08645402 chr16:4508243 NA 0.54 8.79 0.44 8.54e-17 Schizophrenia; CRC cis rs225245 0.817 rs225302 chr17:33922396 C/T cg05299278 chr17:33885742 SLFN14 0.49 7.98 0.4 2.48e-14 Reticulocyte count;Reticulocyte fraction of red cells;High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells; CRC cis rs3026101 0.671 rs1806242 chr17:5304763 T/C cg25236894 chr17:5323110 RPAIN;NUP88 0.42 6.9 0.36 2.74e-11 Body mass index; CRC cis rs1200821 0.529 rs4934856 chr10:37807847 T/C cg00409905 chr10:38381863 ZNF37A 0.47 7.29 0.37 2.38e-12 Hemostatic factors and hematological phenotypes; CRC cis rs6761276 0.837 rs11887823 chr2:113835311 T/A cg24553058 chr2:113831203 IL1F10 0.39 6.3 0.33 9.43e-10 Protein quantitative trait loci; CRC cis rs1448094 0.512 rs4488288 chr12:86245450 A/C cg00310523 chr12:86230176 RASSF9 0.33 5.62 0.3 3.97e-8 Major depressive disorder; CRC cis rs4665809 1.000 rs4665821 chr2:26309949 A/C cg26119090 chr2:26468346 HADHA;HADHB -0.62 -7.94 -0.4 3.22e-14 Gut microbiome composition (summer); CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg06545189 chr10:75936595 ADK 0.47 6.49 0.34 3.22e-10 Anxiety disorder; CRC cis rs10791097 0.694 rs61910787 chr11:130744473 G/A cg12179176 chr11:130786555 SNX19 0.75 12.66 0.57 3.28e-30 Autism spectrum disorder or schizophrenia;Schizophrenia; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg05438183 chr7:149582572 NA -0.43 -7.12 -0.37 6.85e-12 Liver disease severity in Alagille syndrome; CRC cis rs6754459 0.666 rs11674266 chr2:3705291 A/G cg00999904 chr2:3704751 ALLC -0.44 -6.61 -0.34 1.53e-10 Response to inhaled corticosteroid treatment in asthma (change in FEV1); CRC cis rs6752107 1.000 rs6738490 chr2:234161583 T/C cg07618928 chr2:234183455 ATG16L1;SCARNA5 0.65 11.38 0.53 1.56e-25 Crohn's disease;Inflammatory bowel disease; CRC cis rs4664308 0.935 rs6739867 chr2:160942818 G/A cg03641300 chr2:160917029 PLA2R1 -0.73 -11.83 -0.55 3.66e-27 Idiopathic membranous nephropathy; CRC cis rs4862750 0.872 rs7679956 chr4:187900229 C/T cg07414643 chr4:187882934 NA 0.33 5.69 0.3 2.88e-8 Lobe attachment (rater-scored or self-reported); CRC cis rs9393692 0.557 rs61324092 chr6:26297392 G/A cg00631329 chr6:26305371 NA -0.53 -8.86 -0.44 5.06e-17 Educational attainment; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg12583927 chr10:61469753 SLC16A9 -0.4 -6.2 -0.32 1.69e-9 Myopia (pathological); CRC cis rs10751667 0.961 rs7479171 chr11:926809 G/A ch.11.42038R chr11:967971 AP2A2 0.71 11.93 0.55 1.64e-27 Alzheimer's disease (late onset); CRC cis rs1448094 0.511 rs7959372 chr12:86160680 T/C cg00310523 chr12:86230176 RASSF9 0.38 6.09 0.32 3.11e-9 Major depressive disorder; CRC trans rs11581859 0.950 rs56012015 chr1:99362046 T/A cg12183875 chr3:169587454 LRRC31 0.25 5.99 0.31 5.39e-9 Response to cognitive-behavioural therapy in anxiety disorder; CRC cis rs3087591 0.960 rs2071009 chr17:29558082 T/C cg24425628 chr17:29625626 OMG;NF1 -0.86 -16.63 -0.68 1.74e-45 Hip circumference; CRC cis rs769267 0.896 rs10410664 chr19:19556651 G/A cg03709012 chr19:19516395 GATAD2A 0.73 11.48 0.53 6.77e-26 Tonsillectomy; CRC cis rs10504229 0.728 rs17215753 chr8:58153764 A/G cg24829409 chr8:58192753 C8orf71 -0.58 -7.96 -0.4 2.86e-14 Developmental language disorder (linguistic errors); CRC cis rs7809950 1.000 rs2712215 chr7:107188207 A/G cg23024343 chr7:107201750 COG5 -0.62 -8.79 -0.44 8.52e-17 Coronary artery disease; CRC cis rs6951245 1.000 rs78158942 chr7:1090440 G/T cg24642844 chr7:1081250 C7orf50 -0.8 -9.46 -0.46 6.2e-19 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs10979 0.679 rs9403510 chr6:143892174 C/T cg25407410 chr6:143891975 LOC285740 -0.7 -9.55 -0.47 3.18e-19 Hypospadias; CRC cis rs7789940 1.000 rs73140069 chr7:75986790 T/A cg10167463 chr7:75959203 YWHAG -0.78 -11.32 -0.53 2.53e-25 Multiple sclerosis; CRC cis rs2072499 0.966 rs2984615 chr1:156165317 G/C cg06970220 chr1:156163860 SLC25A44 0.49 6.92 0.36 2.31e-11 Testicular germ cell tumor; CRC cis rs2839186 0.560 rs9975345 chr21:47843004 T/C cg10351095 chr21:47802916 PCNT 0.41 6.89 0.36 2.82e-11 Testicular germ cell tumor; CRC cis rs4243830 0.850 rs4908910 chr1:6599362 T/A cg15205204 chr1:6545172 PLEKHG5 0.4 5.73 0.3 2.26e-8 Body mass index; CRC cis rs10504229 0.728 rs72650856 chr8:58152695 C/T cg21724239 chr8:58056113 NA 0.62 8.38 0.42 1.51e-15 Developmental language disorder (linguistic errors); CRC cis rs10504229 0.775 rs17216236 chr8:58159352 G/A cg22535103 chr8:58192502 C8orf71 -0.7 -8.48 -0.42 7.67e-16 Developmental language disorder (linguistic errors); CRC cis rs78545713 0.649 rs16891464 chr6:26235300 A/G cg01420254 chr6:26195488 NA 0.63 6.21 0.32 1.58e-9 Iron status biomarkers (total iron binding capacity); CRC cis rs34375054 1.000 rs3751178 chr12:125664357 C/T cg06287003 chr12:125626642 AACS 0.5 7.22 0.37 3.53e-12 Post bronchodilator FEV1/FVC ratio; CRC trans rs2797160 1.000 rs1739352 chr6:126005310 T/C cg05039488 chr6:79577232 IRAK1BP1 -0.49 -7.32 -0.37 1.91e-12 Endometrial cancer; CRC cis rs9747201 1.000 rs12943668 chr17:80109930 C/T cg09264619 chr17:80180166 NA 0.51 7.31 0.37 1.99e-12 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs4713118 0.513 rs149878 chr6:27878738 T/G cg03623178 chr6:28175578 NA 0.8 12.08 0.55 4.79e-28 Parkinson's disease; CRC cis rs853679 0.517 rs9393884 chr6:28046789 A/G cg25164649 chr6:28176230 NA 0.71 8.96 0.44 2.42e-17 Depression; CRC cis rs8141797 0.901 rs176161 chr22:24516291 C/T cg20894457 chr22:24584366 SUSD2 0.65 6.81 0.35 4.69e-11 Amyotrophic lateral sclerosis;Coronary artery disease; CRC cis rs28498503 0.867 rs1841765 chr18:76644636 A/T cg00806245 chr18:76673096 NA -0.59 -5.87 -0.31 1.05e-8 Attention function in attention deficit hyperactive disorder; CRC cis rs6502050 0.799 rs4789681 chr17:80100546 G/A cg25804541 chr17:80189381 SLC16A3 -0.31 -5.97 -0.31 6.08e-9 Life satisfaction; CRC cis rs28386778 0.897 rs4968663 chr17:61835603 A/T cg07362569 chr17:61921086 SMARCD2 0.37 5.73 0.3 2.27e-8 Prudent dietary pattern; CRC cis rs3087591 1.000 rs2953015 chr17:29495341 A/G cg24425628 chr17:29625626 OMG;NF1 0.87 16.06 0.66 2.96e-43 Hip circumference; CRC cis rs709400 0.628 rs2273700 chr14:103923414 A/G cg12935359 chr14:103987150 CKB -0.51 -7.96 -0.4 2.89e-14 Body mass index; CRC cis rs7666738 0.962 rs11728816 chr4:98951767 C/T cg17366294 chr4:99064904 C4orf37 0.47 7.5 0.38 6.13e-13 Colonoscopy-negative controls vs population controls; CRC cis rs524281 0.773 rs2155201 chr11:65992344 T/C cg14036092 chr11:66035641 RAB1B -0.56 -6.36 -0.33 6.73e-10 Electroencephalogram traits; CRC trans rs12519859 1 rs12519859 chr5:32581186 G/A cg03755955 chr8:6424269 MCPH1 0.42 6.29 0.33 9.86e-10 Breast cancer; CRC cis rs477895 0.653 rs11601577 chr11:63928574 C/T cg05016508 chr11:63871570 FLRT1;MACROD1 0.55 7.21 0.37 3.77e-12 Mean platelet volume; CRC cis rs6502050 0.777 rs11077969 chr17:80085633 A/G cg13198984 chr17:80129470 CCDC57 -0.48 -8.56 -0.43 4.49e-16 Life satisfaction; CRC cis rs7552404 0.924 rs1146580 chr1:76209935 T/C cg03433033 chr1:76189801 ACADM 0.76 11.55 0.54 3.89e-26 Blood metabolite levels;Acylcarnitine levels; CRC cis rs941873 0.869 rs7917610 chr10:81117237 T/C cg08514558 chr10:81106712 PPIF 0.36 5.79 0.3 1.65e-8 Height; CRC cis rs523522 0.847 rs11065132 chr12:120908459 C/T cg12219531 chr12:120966889 COQ5 0.71 9.34 0.46 1.55e-18 High light scatter reticulocyte count; CRC trans rs10504229 1.000 rs66840104 chr8:58190001 C/T cg04077850 chr5:125800366 GRAMD3 0.37 6.27 0.33 1.15e-9 Developmental language disorder (linguistic errors); CRC cis rs12477438 0.520 rs6743355 chr2:99732360 C/G cg26064155 chr2:99771622 LIPT1;TSGA10 0.89 16.26 0.67 4.63e-44 Chronic sinus infection; CRC cis rs9399135 0.967 rs4896123 chr6:135295410 T/G cg22676075 chr6:135203613 NA 0.41 6.19 0.32 1.74e-9 Red blood cell count; CRC cis rs919433 0.963 rs1366837 chr2:198160501 T/C cg03934865 chr2:198174659 NA -0.45 -8.11 -0.41 9.84e-15 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC cis rs1865760 0.566 rs4529296 chr6:26083135 C/G cg16482183 chr6:26056742 HIST1H1C 0.52 7.58 0.39 3.66e-13 Height; CRC cis rs7043114 0.525 rs7020874 chr9:95112560 G/A cg14631576 chr9:95140430 CENPP -0.31 -5.86 -0.31 1.14e-8 Height; CRC cis rs748404 0.578 rs2278856 chr15:43631356 G/A cg02155558 chr15:43621948 ADAL;LCMT2 0.52 7.75 0.39 1.18e-13 Lung cancer; CRC cis rs4700695 0.841 rs251308 chr5:65284279 C/T cg21114390 chr5:65439923 SFRS12 -0.54 -6.12 -0.32 2.73e-9 Facial morphology (factor 19); CRC trans rs208520 1.000 rs72884017 chr6:66992513 T/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.91 11.06 0.52 2.21e-24 Exhaled nitric oxide output; CRC cis rs7113874 0.569 rs4620720 chr11:8615939 G/A cg02811074 chr11:8615871 STK33 0.34 6.03 0.32 4.3e-9 Body mass index in physically active individuals;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs35306767 0.714 rs12767171 chr10:1084491 A/G cg20503657 chr10:835505 NA 0.66 9.07 0.45 1.08e-17 Eosinophil percentage of granulocytes; CRC cis rs1023500 0.551 rs2859438 chr22:42466980 A/T cg04733989 chr22:42467013 NAGA 0.6 9.09 0.45 9.84e-18 Schizophrenia; CRC cis rs7662987 0.517 rs2851268 chr4:100027878 A/G cg13256891 chr4:100009986 ADH5 0.63 8.56 0.43 4.54e-16 Smoking initiation; CRC trans rs916888 0.821 rs199513 chr17:44856932 A/G cg23590916 chr17:43697445 MGC57346 -0.55 -6.17 -0.32 1.98e-9 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs6121246 0.909 rs1994250 chr20:30287494 A/G cg07809909 chr20:30433512 FOXS1 0.35 5.7 0.3 2.65e-8 Mean corpuscular hemoglobin; CRC cis rs4285028 0.948 rs13067270 chr3:121673901 A/C cg11130432 chr3:121712080 ILDR1 -0.52 -6.75 -0.35 6.81e-11 Multiple sclerosis; CRC cis rs897984 0.806 rs11150600 chr16:30940331 C/T cg02466173 chr16:30829666 NA 0.66 10.0 0.48 9.53e-21 Dementia with Lewy bodies; CRC cis rs4481887 0.962 rs4369256 chr1:248492274 G/A cg13385794 chr1:248469461 NA 0.39 6.63 0.34 1.35e-10 Common traits (Other); CRC cis rs9435341 0.965 rs61798468 chr1:107569316 T/G cg09367891 chr1:107599246 PRMT6 0.67 9.86 0.48 2.83e-20 Facial morphology (factor 21, depth of nasal alae); CRC cis rs7605827 0.930 rs13035937 chr2:15698050 C/T cg19274914 chr2:15703543 NA -0.4 -6.06 -0.32 3.71e-9 Educational attainment (years of education); CRC trans rs916888 0.610 rs199438 chr17:44791643 G/A cg07870213 chr5:140052090 DND1 0.63 8.06 0.41 1.41e-14 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs853679 0.517 rs6932109 chr6:28078303 A/G cg15845792 chr6:28175446 NA -0.96 -13.44 -0.6 3.84e-33 Depression; CRC cis rs6701037 0.681 rs2285220 chr1:175130773 T/A cg14847009 chr1:175162515 KIAA0040 -0.26 -5.75 -0.3 2.06e-8 Alcohol dependence; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg19566272 chr6:139695824 CITED2 0.43 6.16 0.32 2.1e-9 Intelligence (multi-trait analysis); CRC cis rs8072100 1.000 rs11650372 chr17:45721795 G/A cg25173405 chr17:45401733 C17orf57 -0.46 -7.21 -0.37 3.76e-12 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs9486715 0.867 rs926277 chr6:96868837 T/A cg06623918 chr6:96969491 KIAA0776 1.02 20.3 0.75 5.5e-60 Headache; CRC cis rs595982 0.527 rs73061658 chr19:49372376 G/C cg15549821 chr19:49342101 PLEKHA4 -0.59 -6.87 -0.35 3.2e-11 Red cell distribution width; CRC cis rs2842992 0.789 rs9364536 chr6:160225559 G/C cg19482086 chr6:160211437 TCP1;MRPL18 0.74 9.59 0.47 2.24e-19 Age-related macular degeneration (geographic atrophy); CRC trans rs3808502 0.526 rs11783065 chr8:11417257 A/G cg16141378 chr3:129829833 LOC729375 0.45 6.87 0.35 3.28e-11 Neuroticism; CRC cis rs11190604 0.943 rs3750631 chr10:102279294 A/G cg16342193 chr10:102329863 NA -0.35 -5.92 -0.31 8e-9 Palmitoleic acid (16:1n-7) levels; CRC cis rs4234284 0.556 rs9968173 chr3:126965437 G/A cg27326032 chr3:127006922 NA -0.52 -7.53 -0.38 4.86e-13 Adverse response to chemotherapy in breast cancer (alopecia) (docetaxel); CRC trans rs1814175 0.591 rs11040589 chr11:49862449 A/G cg11707556 chr5:10655725 ANKRD33B -0.52 -10.01 -0.48 9.28e-21 Height; CRC cis rs7666738 0.830 rs2114425 chr4:99023967 T/C cg17366294 chr4:99064904 C4orf37 0.45 7.51 0.38 5.74e-13 Colonoscopy-negative controls vs population controls; CRC cis rs56104184 0.775 rs56349331 chr19:49403009 T/A cg21252483 chr19:49399788 TULP2 -0.43 -6.52 -0.34 2.59e-10 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; CRC cis rs4730250 0.707 rs10953537 chr7:107027905 G/A cg02696742 chr7:106810147 HBP1 -0.59 -6.22 -0.32 1.52e-9 Osteoarthritis; CRC cis rs875971 0.862 rs778724 chr7:65829291 T/C cg18876405 chr7:65276391 NA 0.51 8.52 0.43 5.71e-16 Aortic root size; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg05602987 chr16:28834702 ATXN2L -0.44 -6.67 -0.35 1.1e-10 Myopia (pathological); CRC cis rs4665809 1.000 rs4665823 chr2:26312723 A/G cg22920501 chr2:26401640 FAM59B -0.53 -7.22 -0.37 3.74e-12 Gut microbiome composition (summer); CRC cis rs10504229 0.679 rs2317991 chr8:58035080 C/T cg02725872 chr8:58115012 NA 0.35 6.17 0.32 1.97e-9 Developmental language disorder (linguistic errors); CRC cis rs2976388 0.647 rs2164307 chr8:143788831 A/T cg15511327 chr8:143859410 LYNX1 0.41 7.41 0.38 1.06e-12 Urinary tract infection frequency; CRC cis rs35110281 0.715 rs8129601 chr21:45119104 A/G cg21573476 chr21:45109991 RRP1B -0.39 -5.9 -0.31 8.97e-9 Mean corpuscular volume; CRC cis rs611744 0.631 rs627392 chr8:109254677 C/T cg18478394 chr8:109455254 TTC35 0.39 6.03 0.32 4.51e-9 Dupuytren's disease; CRC cis rs6694672 1.000 rs1170881 chr1:196949271 G/A cg13682187 chr1:196946512 CFHR5 -0.58 -8.5 -0.42 6.6e-16 Asthma; CRC cis rs56104184 0.779 rs17206686 chr19:49356317 A/G cg15549821 chr19:49342101 PLEKHA4 -0.84 -10.12 -0.49 3.98e-21 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; CRC cis rs2463822 0.925 rs74692811 chr11:62156572 G/A cg06239285 chr11:62104954 ASRGL1 -0.96 -10.97 -0.52 4.56e-24 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs4147929 0.532 rs2242437 chr19:1065563 G/C cg26576206 chr19:1064938 ABCA7 0.42 5.96 0.31 6.6e-9 Alzheimer's disease (late onset); CRC cis rs7772486 0.641 rs2253757 chr6:146199686 C/T cg05347473 chr6:146136440 FBXO30 0.48 6.9 0.36 2.7e-11 Lobe attachment (rater-scored or self-reported); CRC cis rs13118159 0.550 rs28614045 chr4:1374695 C/A cg02018176 chr4:1364513 KIAA1530 0.67 11.61 0.54 2.38e-26 Longevity; CRC cis rs1005277 0.579 rs2505194 chr10:38393881 C/T cg25427524 chr10:38739819 LOC399744 -0.77 -13.49 -0.6 2.67e-33 Extrinsic epigenetic age acceleration; CRC cis rs853679 0.517 rs36078605 chr6:28078032 A/C cg21251018 chr6:28226885 NKAPL 0.47 6.06 0.32 3.79e-9 Depression; CRC cis rs1448094 0.817 rs10863108 chr12:86328249 C/T cg25456477 chr12:86230367 RASSF9 0.34 5.74 0.3 2.14e-8 Major depressive disorder; CRC trans rs7618501 0.602 rs2526754 chr3:50125996 G/A cg21659725 chr3:3221576 CRBN -0.55 -8.7 -0.43 1.64e-16 Intelligence (multi-trait analysis); CRC cis rs875971 0.825 rs6951503 chr7:65718936 T/G cg00343986 chr7:65444356 GUSB -0.43 -5.89 -0.31 9.46e-9 Aortic root size; CRC cis rs1008375 0.966 rs4698621 chr4:17587565 C/T cg02297831 chr4:17616191 MED28 0.44 5.79 0.3 1.67e-8 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs9311474 0.508 rs12629701 chr3:52619836 T/C cg18099408 chr3:52552593 STAB1 -0.49 -8.44 -0.42 1e-15 Electroencephalogram traits; CRC trans rs1005277 0.579 rs2474572 chr10:38385316 A/G cg23533926 chr12:111358616 MYL2 -0.53 -8.19 -0.41 5.94e-15 Extrinsic epigenetic age acceleration; CRC cis rs12908161 0.960 rs34452033 chr15:85221993 A/G cg11189052 chr15:85197271 WDR73 0.61 8.67 0.43 2.06e-16 Schizophrenia; CRC cis rs1552244 0.810 rs6809572 chr3:10100145 G/A cg13047869 chr3:10149882 C3orf24 0.57 7.8 0.4 8.27e-14 Alzheimer's disease; CRC cis rs11190604 1.000 rs12354411 chr10:102294537 G/A cg16342193 chr10:102329863 NA -0.36 -5.99 -0.31 5.62e-9 Palmitoleic acid (16:1n-7) levels; CRC cis rs9393692 0.902 rs6456711 chr6:26302572 A/C cg13736514 chr6:26305472 NA -0.65 -11.75 -0.54 7.23e-27 Educational attainment; CRC cis rs7659604 0.539 rs11098645 chr4:122729251 G/A cg23574427 chr4:122746245 BBS7;CCNA2 -0.3 -5.64 -0.3 3.75e-8 Type 2 diabetes; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg08039701 chr5:74063125 NSA2;GFM2 0.45 6.98 0.36 1.67e-11 Liver disease severity in Alagille syndrome; CRC cis rs908922 0.676 rs4845441 chr1:152485421 C/T cg23254163 chr1:152506842 NA 0.46 9.36 0.46 1.28e-18 Hair morphology; CRC cis rs763121 0.853 rs6001188 chr22:39062194 T/C cg06544989 chr22:39130855 UNC84B 0.45 6.95 0.36 2e-11 Menopause (age at onset); CRC cis rs769267 0.930 rs6909 chr19:19619542 A/G cg03709012 chr19:19516395 GATAD2A 0.72 11.21 0.53 6.56e-25 Tonsillectomy; CRC cis rs79387448 1.000 rs79387448 chr2:103215410 C/T cg00507830 chr2:103233733 NA 0.74 7.98 0.4 2.38e-14 Gut microbiota (bacterial taxa); CRC cis rs3806843 0.966 rs2563263 chr5:140137644 A/G cg16607685 chr5:140181889 PCDHA2;PCDHA1;PCDHA3 -0.27 -6.31 -0.33 9.08e-10 Depressive symptoms (multi-trait analysis); CRC cis rs10206020 0.797 rs72778008 chr2:1573182 T/G cg12573674 chr2:1569213 NA -0.82 -10.96 -0.52 5.02e-24 IgG glycosylation; CRC cis rs7591163 0.959 rs2396497 chr2:228724139 T/C cg08034379 chr2:228736324 WDR69 -0.51 -6.9 -0.36 2.63e-11 Blood pressure; CRC cis rs58688157 0.705 rs7112149 chr11:595890 G/A cg09218773 chr11:619014 MUPCDH -0.43 -6.34 -0.33 7.78e-10 Systemic lupus erythematosus; CRC cis rs2860975 0.967 rs11188134 chr10:96774255 G/C cg09036531 chr10:96991505 NA -0.42 -5.64 -0.3 3.73e-8 Immune response to smallpox vaccine (IL-6); CRC cis rs10479542 0.784 rs7703730 chr5:178986632 C/A cg21226059 chr5:178986404 RUFY1 -0.34 -6.12 -0.32 2.61e-9 Lung cancer; CRC cis rs8060686 0.858 rs7199443 chr16:67841129 T/G cg26727032 chr16:67993705 SLC12A4 -0.71 -11.25 -0.53 4.82e-25 HDL cholesterol;Metabolic syndrome; CRC cis rs4664293 0.539 rs7580661 chr2:160445837 C/G cg08347373 chr2:160653686 CD302 -0.38 -6.44 -0.33 4.12e-10 Monocyte percentage of white cells; CRC cis rs780096 0.526 rs780107 chr2:27684734 A/G cg12648201 chr2:27665141 KRTCAP3 -0.31 -6.28 -0.33 1.05e-9 Total body bone mineral density; CRC cis rs7666738 0.830 rs11931166 chr4:99054187 A/T cg05340658 chr4:99064831 C4orf37 0.6 9.37 0.46 1.17e-18 Colonoscopy-negative controls vs population controls; CRC cis rs1881797 0.527 rs78486847 chr1:247638515 C/T cg21399703 chr1:247681439 NA 0.51 5.75 0.3 2e-8 Acute lymphoblastic leukemia (childhood); CRC cis rs7772486 0.875 rs2814874 chr6:146305895 C/T cg13319975 chr6:146136371 FBXO30 -0.4 -5.93 -0.31 7.7e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs9322193 0.886 rs9485408 chr6:149940024 T/C cg05861140 chr6:150128134 PCMT1 -0.36 -5.92 -0.31 8.15e-9 Lung cancer; CRC cis rs2243480 0.708 rs35310401 chr7:65390359 A/G cg12463550 chr7:65579703 CRCP 0.63 6.04 0.32 4.17e-9 Diabetic kidney disease; CRC cis rs4654899 0.865 rs6693020 chr1:21378057 A/G cg02927042 chr1:21476669 EIF4G3 -0.5 -7.4 -0.38 1.17e-12 Superior frontal gyrus grey matter volume; CRC cis rs12926788 0.542 rs6497759 chr16:24801737 G/A cg00339695 chr16:24857497 SLC5A11 0.43 8.7 0.43 1.65e-16 Ejection fraction in Tripanosoma cruzi seropositivity; CRC cis rs1552244 1.000 rs9827740 chr3:10120531 T/C cg18598329 chr3:10140678 FANCD2;C3orf24 -0.9 -12.84 -0.58 7.52e-31 Alzheimer's disease; CRC cis rs1129187 0.967 rs3805951 chr6:42937176 C/A cg10862848 chr6:42927986 GNMT -0.38 -8.93 -0.44 3.17e-17 Alzheimer's disease in APOE e4+ carriers; CRC cis rs9649213 0.555 rs6948346 chr7:97959956 A/G cg24562669 chr7:97807699 LMTK2 0.4 6.41 0.33 4.98e-10 Prostate cancer (SNP x SNP interaction); CRC cis rs7833790 0.724 rs1054078 chr8:82712153 A/G cg17211192 chr8:82754475 SNX16 -0.47 -6.67 -0.35 1.08e-10 Diastolic blood pressure; CRC cis rs79349575 0.783 rs4793995 chr17:47019399 A/C cg22482690 chr17:47019901 SNF8 0.48 8.01 0.4 2.01e-14 Type 2 diabetes; CRC cis rs3931020 0.508 rs2345436 chr1:75198740 A/C cg10128416 chr1:75198403 TYW3;CRYZ 0.47 6.4 0.33 5.36e-10 Resistin levels; CRC cis rs10504073 0.584 rs62507210 chr8:49946601 C/T cg00325661 chr8:49890786 NA 0.58 10.58 0.5 1.07e-22 Blood metabolite ratios; CRC cis rs3733585 0.781 rs13103879 chr4:9972879 T/C cg11266682 chr4:10021025 SLC2A9 -0.47 -9.45 -0.46 6.6e-19 Cleft plate (environmental tobacco smoke interaction); CRC cis rs561341 0.830 rs2301765 chr17:30202056 T/A cg12193833 chr17:30244370 NA 0.56 6.92 0.36 2.32e-11 Hip circumference adjusted for BMI; CRC cis rs10504229 0.683 rs2005392 chr8:58106896 T/C cg05313129 chr8:58192883 C8orf71 -0.43 -5.87 -0.31 1.09e-8 Developmental language disorder (linguistic errors); CRC cis rs1865760 0.865 rs1436306 chr6:25948421 A/G cg17691542 chr6:26056736 HIST1H1C 0.52 7.64 0.39 2.37e-13 Height; CRC cis rs73206853 0.698 rs73191806 chr12:110899913 A/G cg12870014 chr12:110450643 ANKRD13A 0.84 9.88 0.48 2.53e-20 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC cis rs875971 0.723 rs28391294 chr7:65654315 T/C cg18252515 chr7:66147081 NA 0.39 5.6 0.3 4.46e-8 Aortic root size; CRC cis rs933688 0.877 rs1477349 chr5:90707773 G/A cg02339078 chr5:90679543 LOC100129716;ARRDC3 0.92 13.87 0.61 9.28e-35 Smoking behavior; CRC cis rs365302 1.000 rs375512 chr6:159646450 T/A cg14500486 chr6:159655392 FNDC1 0.43 6.68 0.35 1e-10 Coronary heart disease; CRC cis rs245880 0.740 rs245897 chr7:29193940 C/T cg17163760 chr7:29186267 CPVL 0.38 6.72 0.35 8.12e-11 Warfarin maintenance dose; CRC cis rs7666738 0.830 rs7678911 chr4:99057430 C/T cg05340658 chr4:99064831 C4orf37 0.6 9.3 0.46 2.03e-18 Colonoscopy-negative controls vs population controls; CRC cis rs2304069 0.545 rs9686746 chr5:149399968 G/A cg12661370 chr5:149340060 SLC26A2 0.45 6.5 0.34 2.91e-10 HIV-1 control; CRC cis rs6860806 0.507 rs270608 chr5:131648406 C/T cg27615366 chr5:131592974 PDLIM4 0.34 5.87 0.31 1.09e-8 Breast cancer; CRC cis rs1008375 1.000 rs62295634 chr4:17685346 C/A cg04450456 chr4:17643702 FAM184B 0.38 6.23 0.32 1.43e-9 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs10504229 0.906 rs59336968 chr8:58176857 T/C cg01721255 chr8:58191610 C8orf71 0.49 6.17 0.32 2e-9 Developmental language disorder (linguistic errors); CRC cis rs4253772 0.614 rs11090859 chr22:46687460 T/G cg24881330 chr22:46731750 TRMU 0.68 8.63 0.43 2.7e-16 LDL cholesterol;Cholesterol, total; CRC cis rs7149337 0.717 rs4309324 chr14:51606336 A/T cg18683604 chr14:51561293 TRIM9 -0.34 -6.46 -0.34 3.67e-10 Cancer; CRC cis rs5753618 0.561 rs2413049 chr22:31686144 A/G cg22777020 chr22:31556080 RNF185 -0.52 -5.9 -0.31 8.86e-9 Colorectal cancer; CRC cis rs3008870 0.677 rs2815354 chr1:67483642 A/T cg11518657 chr1:67396239 MIER1 0.57 6.21 0.32 1.59e-9 Lymphocyte percentage of white cells; CRC trans rs1814175 0.817 rs28502006 chr11:50049930 T/C cg03929089 chr4:120376271 NA -0.93 -17.98 -0.7 7.84e-51 Height; CRC cis rs9611565 0.546 rs5758430 chr22:42109844 G/T cg06634786 chr22:41940651 POLR3H 0.6 7.02 0.36 1.24e-11 Vitiligo; CRC cis rs910316 1.000 rs12889309 chr14:75593902 C/T cg03030879 chr14:75389066 RPS6KL1 -0.47 -7.4 -0.38 1.11e-12 Height; CRC cis rs2204008 0.529 rs1315350 chr12:38164282 C/A cg13010199 chr12:38710504 ALG10B -0.43 -6.21 -0.32 1.62e-9 Bladder cancer; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg11050527 chr8:54755511 ATP6V1H 0.49 6.31 0.33 9.24e-10 Thyroid stimulating hormone; CRC cis rs9435341 0.965 rs6669831 chr1:107608607 G/A cg14671364 chr1:107599128 PRMT6 -0.53 -7.53 -0.38 4.8e-13 Facial morphology (factor 21, depth of nasal alae); CRC cis rs6463523 0.933 rs4724821 chr7:762544 C/T cg14391382 chr7:866102 UNC84A 0.5 7.26 0.37 2.81e-12 Subjective well-being; CRC cis rs6060960 0.502 rs6057968 chr20:30082779 A/T cg18721089 chr20:30220636 NA -0.48 -7.74 -0.39 1.26e-13 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; CRC cis rs1448094 0.511 rs10863079 chr12:86152700 T/A cg02569458 chr12:86230093 RASSF9 -0.48 -7.92 -0.4 3.61e-14 Major depressive disorder; CRC cis rs4663866 0.901 rs35713061 chr2:239183774 C/T cg16914508 chr2:239161102 PER2 0.77 7.88 0.4 4.92e-14 Irritable bowel syndrome; CRC cis rs6951245 0.938 rs11764937 chr7:1092074 C/T cg26224354 chr7:1096374 C7orf50;GPR146 -0.92 -12.14 -0.56 2.79e-28 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg00377757 chr17:76921538 TIMP2 0.39 6.28 0.33 1.08e-9 Obesity-related traits; CRC cis rs10504229 0.679 rs16920056 chr8:58106218 C/A cg02725872 chr8:58115012 NA -0.66 -11.36 -0.53 1.85e-25 Developmental language disorder (linguistic errors); CRC cis rs4665809 0.590 rs2033317 chr2:26477650 G/A cg27170947 chr2:26402098 FAM59B 0.62 8.31 0.42 2.62e-15 Gut microbiome composition (summer); CRC cis rs561341 1.000 rs530715 chr17:30320544 T/G cg00745463 chr17:30367425 LRRC37B -0.74 -8.94 -0.44 2.93e-17 Hip circumference adjusted for BMI; CRC cis rs877282 0.733 rs11253342 chr10:765072 A/G cg17470449 chr10:769945 NA 0.66 8.48 0.42 7.57e-16 Uric acid levels; CRC cis rs3026101 0.624 rs11869800 chr17:5307781 G/A cg25236894 chr17:5323110 RPAIN;NUP88 0.42 6.9 0.36 2.74e-11 Body mass index; CRC cis rs7617773 0.779 rs1045482 chr3:48312229 A/G cg11946769 chr3:48343235 NME6 0.56 8.06 0.41 1.38e-14 Coronary artery disease; CRC cis rs9926296 0.581 rs12598477 chr16:89902482 T/C cg03605463 chr16:89740564 NA -0.4 -5.68 -0.3 2.97e-8 Vitiligo; CRC cis rs736408 0.545 rs6445529 chr3:52662722 T/A cg18099408 chr3:52552593 STAB1 -0.47 -8.07 -0.41 1.32e-14 Bipolar disorder; CRC cis rs2153535 0.580 rs4404802 chr6:8442052 A/G cg07606381 chr6:8435919 SLC35B3 0.68 10.86 0.51 1.08e-23 Motion sickness; CRC cis rs2274471 0.716 rs10974911 chr9:5010471 C/A cg03390472 chr9:5043263 JAK2 -0.59 -6.66 -0.34 1.17e-10 Crohn's disease; CRC cis rs9322193 0.923 rs10782310 chr6:149943594 A/G cg00933542 chr6:150070202 PCMT1 0.29 6.12 0.32 2.69e-9 Lung cancer; CRC trans rs2303319 0.504 rs1006427 chr2:162592328 T/C cg22627826 chr19:1240265 ATP5D -0.72 -6.24 -0.33 1.32e-9 Cognitive function; CRC cis rs2625529 0.730 rs2957725 chr15:72248205 C/A cg16672083 chr15:72433130 SENP8 0.45 6.48 0.34 3.27e-10 Red blood cell count; CRC cis rs4862750 0.872 rs7679956 chr4:187900229 C/T cg03452623 chr4:187889614 NA -0.95 -23.72 -0.79 3.41e-73 Lobe attachment (rater-scored or self-reported); CRC cis rs3096299 0.967 rs11648663 chr16:89466307 C/T cg01788221 chr16:89496183 ANKRD11 -0.45 -6.92 -0.36 2.44e-11 Multiple myeloma (IgH translocation); CRC cis rs1670533 1.000 rs11724371 chr4:1052125 T/C cg27284194 chr4:1044797 NA 0.51 6.04 0.32 4.24e-9 Recombination rate (females); CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg25760412 chr20:36793747 TGM2 0.42 6.13 0.32 2.58e-9 Anxiety disorder; CRC cis rs910316 0.737 rs175499 chr14:75535927 G/A cg11812906 chr14:75593930 NEK9 -0.59 -9.13 -0.45 6.86e-18 Height; CRC cis rs951366 0.617 rs9438393 chr1:205782718 A/G cg14893161 chr1:205819251 PM20D1 1.03 19.53 0.73 6.18e-57 Menarche (age at onset); CRC cis rs10779751 0.686 rs1148478 chr1:11174067 A/T cg08854313 chr1:11322531 MTOR 0.57 7.36 0.38 1.46e-12 Body mass index; CRC cis rs422249 0.504 rs174538 chr11:61560081 G/A cg00603274 chr11:61596626 FADS2 -0.49 -7.0 -0.36 1.41e-11 Trans fatty acid levels; CRC cis rs2019137 0.560 rs7421852 chr2:113990261 G/A cg17445212 chr2:113993313 PAX8;LOC440839;LOC654433 0.49 7.41 0.38 1.06e-12 Lymphocyte counts; CRC trans rs62103177 0.608 rs4799115 chr18:77736365 A/T cg05926928 chr17:57297772 GDPD1 -0.73 -7.04 -0.36 1.11e-11 Opioid sensitivity; CRC cis rs8180040 0.726 rs10461018 chr3:46995242 C/T cg27129171 chr3:47204927 SETD2 -0.72 -11.37 -0.53 1.71e-25 Colorectal cancer; CRC cis rs9309473 1.000 rs13384952 chr2:73723959 C/T cg20560298 chr2:73613845 ALMS1 0.57 6.01 0.31 4.89e-9 Metabolite levels; CRC cis rs1475911 0.708 rs11701371 chr21:43523972 C/G cg24372256 chr21:43528868 UMODL1;C21orf128 -0.69 -10.49 -0.5 2.18e-22 IgG glycosylation; CRC trans rs877282 0.898 rs11253344 chr10:765162 C/T cg22713356 chr15:30763199 NA 1.29 15.31 0.65 2.44e-40 Uric acid levels; CRC cis rs1580019 0.563 rs10486509 chr7:32585443 C/G cg14728415 chr7:32535168 LSM5;AVL9 -0.45 -6.35 -0.33 7.24e-10 Cognitive ability; CRC cis rs2739330 0.753 rs4822452 chr22:24254363 C/T cg24846343 chr22:24311635 DDTL 0.82 14.73 0.63 4.68e-38 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs7274811 0.681 rs291674 chr20:31954890 C/G cg07470512 chr20:32255052 NECAB3;C20orf134 0.43 5.82 0.31 1.36e-8 Height; CRC cis rs12887734 0.569 rs66953418 chr14:104271470 G/A cg01849466 chr14:104193079 ZFYVE21 -0.42 -6.47 -0.34 3.51e-10 Schizophrenia;Autism spectrum disorder or schizophrenia; CRC cis rs789852 0.764 rs1705999 chr3:194316333 C/T cg21106136 chr3:194405973 FAM43A -0.72 -6.03 -0.32 4.44e-9 QT interval; CRC cis rs713587 0.521 rs6545766 chr2:25077856 C/T cg04586622 chr2:25135609 ADCY3 -0.51 -9.36 -0.46 1.27e-18 Body mass index in non-asthmatics; CRC cis rs10540 1.000 rs79808876 chr11:465763 C/A cg03934478 chr11:495069 RNH1 0.65 7.29 0.37 2.31e-12 Body mass index; CRC trans rs6678914 1.000 rs6703244 chr1:202187520 A/G cg19977628 chr5:1262072 TERT 0.43 6.34 0.33 7.43e-10 Breast cancer (estrogen-receptor negative);Breast cancer; CRC cis rs9928842 0.823 rs889514 chr16:75272512 A/G cg09066997 chr16:75300724 BCAR1 0.67 6.93 0.36 2.21e-11 Alcoholic chronic pancreatitis; CRC cis rs9837602 0.529 rs793459 chr3:99520591 G/A cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G -0.49 -6.48 -0.34 3.26e-10 Breast cancer; CRC cis rs9372498 0.706 rs9489396 chr6:118761703 A/C cg15382696 chr6:118971807 C6orf204 0.6 7.67 0.39 1.9e-13 Diastolic blood pressure; CRC cis rs2075371 1.000 rs8134 chr7:133974519 A/G cg02659138 chr7:134003124 SLC35B4 0.36 6.19 0.32 1.76e-9 Mean platelet volume; CRC cis rs763121 0.925 rs5757251 chr22:39100128 G/A cg06022373 chr22:39101656 GTPBP1 0.71 11.33 0.53 2.34e-25 Menopause (age at onset); CRC cis rs7312933 0.701 rs10880260 chr12:42561398 A/G cg11827402 chr12:42719852 PPHLN1;ZCRB1 0.63 8.79 0.44 8.37e-17 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CRC cis rs875971 1.000 rs2087647 chr7:65593188 C/A cg12463550 chr7:65579703 CRCP -0.47 -6.74 -0.35 7.05e-11 Aortic root size; CRC cis rs6964587 0.758 rs35963176 chr7:91617115 C/T cg17063962 chr7:91808500 NA 0.55 7.31 0.37 2.03e-12 Breast cancer; CRC cis rs56146971 0.763 rs55950330 chr14:91872978 C/T cg16433844 chr14:91963127 SMEK1 -0.58 -6.21 -0.32 1.6e-9 Alzheimer disease and age of onset; CRC cis rs6009527 0.752 rs7286232 chr22:49568490 A/G cg12746016 chr22:49560550 NA 0.42 6.48 0.34 3.4e-10 Plasma omega-3 polyunsaturated fatty acid levels (alphalinolenic acid); CRC cis rs77972916 0.505 rs3851318 chr2:43532808 G/C cg06169590 chr2:43455088 ZFP36L2;LOC100129726 -0.53 -6.3 -0.33 9.33e-10 Granulocyte percentage of myeloid white cells; CRC cis rs4253772 0.637 rs6008339 chr22:46650846 C/T cg03482458 chr22:46692211 CN5H6.4;GTSE1 0.46 6.09 0.32 3.1e-9 LDL cholesterol;Cholesterol, total; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg24450365 chr7:89874355 C7orf63 0.42 6.0 0.31 5.35e-9 Response to antipsychotic treatment; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg16650099 chr1:114471848 HIPK1 0.42 5.99 0.31 5.47e-9 Response to antipsychotic treatment; CRC cis rs4523957 0.855 rs11078883 chr17:2138828 C/G cg16513277 chr17:2031491 SMG6 -0.55 -8.58 -0.43 3.93e-16 Autism spectrum disorder or schizophrenia;Schizophrenia; CRC cis rs561341 1.000 rs117029332 chr17:30266085 C/G cg23018236 chr17:30244563 NA -0.66 -7.82 -0.4 7.33e-14 Hip circumference adjusted for BMI; CRC cis rs6540559 0.673 rs17015183 chr1:209948711 A/C cg22029157 chr1:209979665 IRF6 0.72 9.48 0.46 5.22e-19 Cleft lip with or without cleft palate; CRC cis rs11105298 0.891 rs11105302 chr12:89891366 A/G cg08166232 chr12:89918718 WDR51B;GALNT4 0.59 7.65 0.39 2.22e-13 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; CRC cis rs2991971 0.934 rs11211129 chr1:45983080 C/T cg03123370 chr1:45965343 CCDC163P;MMACHC -0.39 -5.84 -0.31 1.24e-8 High light scatter reticulocyte count; CRC cis rs7113874 0.569 rs9737401 chr11:8595652 C/T cg17679104 chr11:8615758 STK33 -0.36 -5.99 -0.31 5.52e-9 Body mass index in physically active individuals;Body mass index (joint analysis main effects and physical activity interaction); CRC trans rs916888 0.773 rs199457 chr17:44795469 C/T cg01341218 chr17:43662625 NA 0.97 10.34 0.5 6.83e-22 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs780096 0.545 rs6716894 chr2:27583273 A/G cg27432699 chr2:27873401 GPN1 -0.52 -7.92 -0.4 3.6e-14 Total body bone mineral density; CRC cis rs2274273 0.662 rs2094436 chr14:55661495 C/G cg10130446 chr14:55658398 DLGAP5 -0.43 -5.75 -0.3 2.08e-8 Protein biomarker; CRC cis rs12188164 0.502 rs55929184 chr5:405576 G/A cg21972741 chr5:435613 AHRR 0.5 6.54 0.34 2.29e-10 Cystic fibrosis severity; CRC cis rs754466 0.580 rs10430529 chr10:79582623 C/A cg17075019 chr10:79541650 NA -0.94 -17.24 -0.69 6.43e-48 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs990171 1.000 rs2272129 chr2:103040249 C/T cg03938978 chr2:103052716 IL18RAP 0.46 5.78 0.3 1.74e-8 Lymphocyte counts; CRC cis rs6545883 0.965 rs6734830 chr2:61731112 G/A cg15711740 chr2:61764176 XPO1 -0.5 -6.87 -0.35 3.23e-11 Tuberculosis; CRC cis rs116095464 0.558 rs9312979 chr5:222057 A/C cg22857025 chr5:266934 NA -1.14 -12.02 -0.55 7.44e-28 Breast cancer; CRC cis rs3760982 0.845 rs62116962 chr19:44287234 A/G cg21496419 chr19:44306685 LYPD5 -0.35 -6.49 -0.34 3.17e-10 Breast cancer (estrogen-receptor negative);Breast cancer; CRC cis rs9398803 0.605 rs112166936 chr6:126733140 A/C cg19875578 chr6:126661172 C6orf173 0.42 5.93 0.31 7.86e-9 Male-pattern baldness; CRC trans rs11098499 0.955 rs4145951 chr4:120155817 A/G cg25214090 chr10:38739885 LOC399744 0.51 7.84 0.4 6.42e-14 Corneal astigmatism; CRC cis rs853679 0.517 rs9357061 chr6:28051772 A/G cg03623178 chr6:28175578 NA 0.94 12.29 0.56 7.67e-29 Depression; CRC cis rs2067615 0.524 rs10778500 chr12:107074410 T/A cg13491945 chr12:107078410 RFX4 0.36 6.16 0.32 2.13e-9 Heart rate; CRC cis rs7615952 0.576 rs6804482 chr3:125815762 C/T cg06494592 chr3:125709126 NA -0.58 -6.89 -0.35 2.9100000000000002e-11 Blood pressure (smoking interaction); CRC cis rs75804782 0.641 rs72985387 chr2:239336589 G/A cg18131467 chr2:239335373 ASB1 -0.7 -6.22 -0.32 1.53e-9 Morning vs. evening chronotype;Chronotype; CRC cis rs476633 0.691 rs2164996 chr15:41536624 A/G cg18705301 chr15:41695430 NDUFAF1 -0.4 -6.68 -0.35 1.02e-10 Glomerular filtration rate (creatinine); CRC cis rs9309473 0.555 rs2901437 chr2:73597024 T/G cg20560298 chr2:73613845 ALMS1 -0.49 -6.68 -0.35 1.03e-10 Metabolite levels; CRC trans rs11581859 0.950 rs72730323 chr1:99387892 A/G cg12183875 chr3:169587454 LRRC31 0.28 6.29 0.33 1.03e-9 Response to cognitive-behavioural therapy in anxiety disorder; CRC cis rs7044106 0.762 rs7849566 chr9:123460769 A/C cg14255062 chr9:123606675 PSMD5;LOC253039 0.44 6.24 0.33 1.34e-9 Hip circumference adjusted for BMI; CRC cis rs10540 1.000 rs12788729 chr11:502371 G/A cg21784768 chr11:537496 LRRC56 -0.69 -6.56 -0.34 2.11e-10 Body mass index; CRC cis rs9916302 0.706 rs801427 chr17:37436711 A/G cg15445000 chr17:37608096 MED1 0.33 5.89 0.31 9.79e-9 Glomerular filtration rate (creatinine); CRC cis rs1348850 0.750 rs12997716 chr2:178494629 G/A cg22681709 chr2:178499509 PDE11A -0.41 -7.52 -0.38 5.3e-13 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs9648716 1.000 rs17161763 chr7:140589239 A/C cg10747023 chr7:140774559 NA 0.44 5.81 0.31 1.46e-8 Type 2 diabetes; CRC cis rs10504229 0.683 rs55660024 chr8:58128943 G/A cg22535103 chr8:58192502 C8orf71 -0.7 -9.34 -0.46 1.47e-18 Developmental language disorder (linguistic errors); CRC cis rs7589728 0.563 rs78685993 chr2:88447026 T/C cg04511125 chr2:88470314 THNSL2 0.82 8.7 0.43 1.59e-16 Plasma clusterin levels; CRC cis rs9807989 0.571 rs10208293 chr2:102966310 G/A cg09003973 chr2:102972529 NA 0.4 5.69 0.3 2.8e-8 Asthma; CRC cis rs10791323 0.569 rs10750542 chr11:133713436 T/C cg03690763 chr11:133734501 NA -0.34 -5.69 -0.3 2.75e-8 Childhood ear infection; CRC cis rs270601 0.710 rs371709 chr5:131583240 A/G cg20512303 chr5:131592959 PDLIM4 0.4 6.96 0.36 1.8e-11 Acylcarnitine levels; CRC cis rs1559088 0.573 rs1270591 chr19:33622942 C/T cg27124370 chr19:33622961 WDR88 -0.48 -7.22 -0.37 3.62e-12 Bone ultrasound measurement (broadband ultrasound attenuation); CRC cis rs881375 0.967 rs7848332 chr9:123669496 T/C cg09586646 chr9:123605570 PSMD5;LOC253039 0.53 7.17 0.37 5.01e-12 Rheumatoid arthritis; CRC cis rs6570726 0.791 rs6914203 chr6:145899975 C/A cg23711669 chr6:146136114 FBXO30 0.66 11.0 0.52 3.46e-24 Lobe attachment (rater-scored or self-reported); CRC cis rs7666738 0.830 rs1876192 chr4:98727555 T/C cg17366294 chr4:99064904 C4orf37 0.42 6.91 0.36 2.59e-11 Colonoscopy-negative controls vs population controls; CRC cis rs9372498 0.536 rs9481833 chr6:118919631 G/A cg01339444 chr6:118972232 C6orf204 0.55 6.16 0.32 2.08e-9 Diastolic blood pressure; CRC cis rs9549328 0.756 rs2993291 chr13:113653846 C/T cg25790453 chr13:113633590 MCF2L -0.5 -7.78 -0.39 9.66e-14 Systolic blood pressure; CRC cis rs10504229 1.000 rs17217082 chr8:58180918 G/A cg22535103 chr8:58192502 C8orf71 -0.82 -12.27 -0.56 9.63e-29 Developmental language disorder (linguistic errors); CRC trans rs11098499 0.754 rs10213267 chr4:120239074 A/G cg25214090 chr10:38739885 LOC399744 0.53 8.45 0.42 9.68e-16 Corneal astigmatism; CRC cis rs7772486 0.790 rs80050589 chr6:146230454 T/C cg13319975 chr6:146136371 FBXO30 0.43 6.51 0.34 2.87e-10 Lobe attachment (rater-scored or self-reported); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg10084289 chr6:111580886 KIAA1919 0.42 6.15 0.32 2.27e-9 Intelligence (multi-trait analysis); CRC cis rs6952808 0.895 rs4513875 chr7:1928159 C/T cg14004847 chr7:1930337 MAD1L1 -0.43 -5.86 -0.31 1.13e-8 Bipolar disorder and schizophrenia; CRC trans rs1455244 0.700 rs7229302 chr18:11508904 G/T cg05365220 chr1:94375159 GCLM 0.39 5.97 0.31 6.27e-9 Schizophrenia; CRC cis rs1784581 0.706 rs9346895 chr6:162431168 T/C cg17173639 chr6:162384350 PARK2 0.68 11.35 0.53 1.99e-25 Itch intensity from mosquito bite; CRC cis rs6951245 1.000 rs118059236 chr7:1073202 A/C cg24642844 chr7:1081250 C7orf50 -0.78 -9.35 -0.46 1.42e-18 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs1348850 0.914 rs2364854 chr2:178378452 T/A cg02961200 chr2:178257176 LOC100130691;AGPS 0.55 8.01 0.4 1.95e-14 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs1971762 0.504 rs1843318 chr12:53958077 C/T cg06632207 chr12:54070931 ATP5G2 0.45 7.57 0.39 3.76e-13 Height; CRC trans rs1607741 1.000 rs10010287 chr4:72711633 G/A cg06437464 chr6:127441704 RSPO3 0.29 6.14 0.32 2.32e-9 Vitamin D levels; CRC cis rs4665809 0.590 rs4665321 chr2:26433801 A/C cg04944784 chr2:26401820 FAM59B -0.86 -11.14 -0.52 1.12e-24 Gut microbiome composition (summer); CRC cis rs60843830 1.000 rs2126129 chr2:212548 C/T cg00108164 chr2:264199 ACP1;SH3YL1 0.61 9.44 0.46 7.04e-19 Spherical equivalent (joint analysis main effects and education interaction); CRC cis rs6951245 1.000 rs11763020 chr7:1060288 C/T cg26224354 chr7:1096374 C7orf50;GPR146 -0.86 -10.78 -0.51 2.06e-23 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs56114371 0.777 rs200481 chr6:27773832 A/T cg15845792 chr6:28175446 NA 0.68 6.09 0.32 3.15e-9 Breast cancer; CRC cis rs2011503 0.943 rs1529745 chr19:19517325 C/G cg11584989 chr19:19387371 SF4 0.56 6.3 0.33 9.63e-10 Bipolar disorder; CRC cis rs6502050 0.635 rs9889327 chr17:80087839 G/A cg02741985 chr17:80059408 CCDC57 0.43 7.13 0.37 6.48e-12 Life satisfaction; CRC cis rs1801251 0.896 rs79793315 chr2:233690864 C/T cg25237894 chr2:233734115 C2orf82 -0.44 -7.09 -0.36 8.09e-12 Coronary artery disease; CRC cis rs9826463 0.582 rs11709758 chr3:142104427 T/C cg20824294 chr3:142316082 PLS1 0.36 5.86 0.31 1.11e-8 QRS duration in Tripanosoma cruzi seropositivity; CRC cis rs6496667 0.779 rs59814752 chr15:91005738 G/A cg04176472 chr15:90893244 GABARAPL3 0.58 8.05 0.41 1.5e-14 Rheumatoid arthritis; CRC cis rs875971 0.825 rs10281499 chr7:66048966 A/G cg12463550 chr7:65579703 CRCP -0.47 -6.38 -0.33 5.88e-10 Aortic root size; CRC cis rs9467711 0.606 rs9393711 chr6:26370659 C/T cg16898833 chr6:26189333 HIST1H4D 0.76 6.58 0.34 1.88e-10 Autism spectrum disorder or schizophrenia; CRC trans rs11098499 0.874 rs6851169 chr4:120117510 T/C cg25214090 chr10:38739885 LOC399744 0.52 7.73 0.39 1.34e-13 Corneal astigmatism; CRC cis rs2011503 1.000 rs75582668 chr19:19569023 C/T cg11584989 chr19:19387371 SF4 0.54 6.1 0.32 2.99e-9 Bipolar disorder; CRC cis rs9467711 0.606 rs35307327 chr6:26370474 C/T cg14345882 chr6:26364793 BTN3A2 0.65 5.74 0.3 2.17e-8 Autism spectrum disorder or schizophrenia; CRC cis rs6088590 0.965 rs910869 chr20:33292777 C/T cg24642439 chr20:33292090 TP53INP2 0.62 11.15 0.52 1.01e-24 Coronary artery disease; CRC cis rs7666738 0.830 rs28810677 chr4:99043193 C/T cg05340658 chr4:99064831 C4orf37 0.6 9.35 0.46 1.36e-18 Colonoscopy-negative controls vs population controls; CRC cis rs2268241 0.938 rs2268242 chr21:34781104 C/T cg14850771 chr21:34775459 IFNGR2 0.77 9.64 0.47 1.6e-19 Obesity-related traits; CRC cis rs2197308 0.765 rs11182964 chr12:37935052 C/T cg13010199 chr12:38710504 ALG10B 0.44 5.62 0.3 4.08e-8 Morning vs. evening chronotype; CRC cis rs1552244 0.608 rs6764807 chr3:9998803 T/C cg16606324 chr3:10149918 C3orf24 0.45 6.8 0.35 4.87e-11 Alzheimer's disease; CRC cis rs17331151 0.573 rs28552648 chr3:52865593 G/A cg06204229 chr3:52865917 ITIH4 0.58 7.94 0.4 3.2e-14 Immune reponse to smallpox (secreted IL-2); CRC trans rs9929218 1.000 rs28660361 chr16:68800838 T/C cg04657470 chr2:198365150 HSPE1;HSPD1 -0.83 -11.86 -0.55 2.96e-27 Colorectal cancer; CRC cis rs12142240 0.698 rs72886911 chr1:46814352 G/A cg14993813 chr1:46806288 NSUN4 -0.5 -6.42 -0.33 4.75e-10 Menopause (age at onset); CRC trans rs561341 0.824 rs1978115 chr17:30220776 A/C cg27661571 chr11:113659931 NA -0.7 -8.06 -0.41 1.44e-14 Hip circumference adjusted for BMI; CRC cis rs4423214 0.840 rs1790340 chr11:71182589 T/C cg05163923 chr11:71159392 DHCR7 -0.64 -7.57 -0.39 3.78e-13 Vitamin D levels; CRC cis rs9814567 0.963 rs36006513 chr3:134291913 T/A cg06109529 chr3:134205091 CEP63;ANAPC13 0.83 12.18 0.56 1.98e-28 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg11916186 chr1:36689760 THRAP3 0.42 6.05 0.32 4.03e-9 Intelligence (multi-trait analysis); CRC cis rs9818758 0.556 rs9835439 chr3:49220330 G/C cg07636037 chr3:49044803 WDR6 -0.65 -5.73 -0.3 2.24e-8 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; CRC cis rs4363385 0.574 rs4041402 chr1:152947397 T/C cg25856811 chr1:152973957 SPRR3 -0.25 -6.73 -0.35 7.51e-11 Inflammatory skin disease; CRC cis rs6952808 0.609 rs4721185 chr7:1951109 T/C cg02951883 chr7:2050386 MAD1L1 -0.54 -8.89 -0.44 3.98e-17 Bipolar disorder and schizophrenia; CRC cis rs2404602 0.692 rs58973160 chr15:77000342 T/C cg03037974 chr15:76606532 NA 0.68 11.71 0.54 1.02e-26 Blood metabolite levels; CRC cis rs798554 0.679 rs1639066 chr7:2892972 A/G cg17321639 chr7:2759063 NA -0.43 -5.62 -0.3 4.12e-8 Height; CRC cis rs9921222 0.597 rs7193109 chr16:413523 T/G cg08923669 chr16:420230 MRPL28 -0.44 -6.24 -0.33 1.34e-9 Bone mineral density (spine);Bone mineral density; CRC trans rs853679 1.000 rs735765 chr6:28170297 G/A cg06606381 chr12:133084897 FBRSL1 -0.76 -7.25 -0.37 2.95e-12 Depression; CRC cis rs9468186 1 rs9468186 chr6:27626631 A/G cg15845792 chr6:28175446 NA 0.56 6.86 0.35 3.47e-11 Neuroticism; CRC cis rs11148252 0.740 rs9536052 chr13:52960709 C/G cg02158880 chr13:53174818 NA -0.43 -6.38 -0.33 5.85e-10 Lewy body disease; CRC cis rs4665809 1.000 rs2384323 chr2:26306473 C/T cg26119090 chr2:26468346 HADHA;HADHB -0.62 -7.93 -0.4 3.4e-14 Gut microbiome composition (summer); CRC cis rs34172651 0.837 rs1978451 chr16:24818286 C/G cg06505273 chr16:24850292 NA 0.39 5.72 0.3 2.33e-8 Intelligence (multi-trait analysis); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg06828538 chr7:5463627 TNRC18 -0.44 -6.64 -0.34 1.3100000000000001e-10 Liver disease severity in Alagille syndrome; CRC cis rs13191362 0.938 rs35211042 chr6:162998703 A/G cg23758597 chr6:163146217 PARK2 -0.51 -5.91 -0.31 8.56e-9 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs1707322 0.686 rs3014242 chr1:46087577 G/A cg03146154 chr1:46216737 IPP -0.66 -9.32 -0.46 1.73e-18 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs10256972 0.577 rs6962809 chr7:1208889 A/G cg07308232 chr7:1071921 C7orf50 -0.43 -5.81 -0.3 1.5e-8 Longevity;Endometriosis; CRC cis rs2228479 0.850 rs12597296 chr16:89822331 C/T cg06656553 chr16:89960601 TCF25 -0.7 -5.76 -0.3 1.93e-8 Skin colour saturation; CRC cis rs6952808 0.862 rs4721135 chr7:1912222 A/G cg00106254 chr7:1943704 MAD1L1 -0.42 -6.61 -0.34 1.54e-10 Bipolar disorder and schizophrenia; CRC cis rs11190604 0.767 rs79106148 chr10:102184732 G/A cg07080220 chr10:102295463 HIF1AN 0.47 5.75 0.3 2.08e-8 Palmitoleic acid (16:1n-7) levels; CRC cis rs11190604 1.000 rs2489045 chr10:102344754 C/T cg16342193 chr10:102329863 NA -0.42 -6.63 -0.34 1.35e-10 Palmitoleic acid (16:1n-7) levels; CRC cis rs853679 0.517 rs9393897 chr6:28127710 G/T cg25164649 chr6:28176230 NA 0.78 9.66 0.47 1.33e-19 Depression; CRC cis rs4853012 0.838 rs61521879 chr2:74346208 T/C cg20891558 chr2:74357851 NA 0.57 9.02 0.45 1.57e-17 Gestational age at birth (maternal effect); CRC cis rs9902453 0.619 rs2617866 chr17:28076217 A/G cg26525008 chr17:28256777 EFCAB5;SSH2 -0.72 -12.23 -0.56 1.27e-28 Coffee consumption (cups per day); CRC cis rs763014 0.932 rs35067229 chr16:649638 T/C cg03804128 chr16:635623 NA 0.32 7.48 0.38 7.03e-13 Height; CRC cis rs875971 0.545 rs4718325 chr7:65680310 G/A cg18876405 chr7:65276391 NA 0.47 6.5 0.34 2.93e-10 Aortic root size; CRC cis rs6545883 0.524 rs778159 chr2:61556744 T/C cg10580144 chr2:61372316 C2orf74 -0.35 -7.78 -0.39 9.42e-14 Tuberculosis; CRC cis rs9399137 0.507 rs4580893 chr6:135297662 G/A cg22676075 chr6:135203613 NA 0.59 8.98 0.44 2.14e-17 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; CRC cis rs875971 1.000 rs2220626 chr7:65546062 C/T cg12463550 chr7:65579703 CRCP -0.49 -7.01 -0.36 1.39e-11 Aortic root size; CRC cis rs2108225 0.872 rs6980029 chr7:107446127 T/C cg18560240 chr7:107437656 SLC26A3 -0.66 -10.29 -0.49 1.05e-21 Ulcerative colitis; CRC cis rs2032447 0.517 rs7767546 chr6:25904067 T/C cg04800585 chr6:26043546 HIST1H2BB 0.46 6.34 0.33 7.5e-10 Intelligence (multi-trait analysis); CRC cis rs868943 0.714 rs66475830 chr6:116408802 T/C cg05304507 chr6:116381966 FRK 0.28 6.31 0.33 8.88e-10 Total cholesterol levels; CRC cis rs4665809 0.531 rs12990692 chr2:26464939 C/T cg27170947 chr2:26402098 FAM59B 0.63 8.51 0.42 6.43e-16 Gut microbiome composition (summer); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg05863116 chr5:133562407 PPP2CA 0.39 6.15 0.32 2.23e-9 Liver disease severity in Alagille syndrome; CRC cis rs10256972 0.616 rs4585652 chr7:1145396 A/G cg03923535 chr7:1197113 ZFAND2A 0.67 9.56 0.47 2.77e-19 Longevity;Endometriosis; CRC cis rs6952808 0.792 rs13224989 chr7:1953766 C/G cg21782813 chr7:2030301 MAD1L1 0.46 7.91 0.4 3.91e-14 Bipolar disorder and schizophrenia; CRC cis rs208520 0.526 rs7776413 chr6:66783241 A/G cg07460842 chr6:66804631 NA -1.16 -24.71 -0.81 5.99e-77 Exhaled nitric oxide output; CRC cis rs1007738 0.542 rs2279438 chr11:47204175 A/T cg19486271 chr11:47235900 DDB2 -0.41 -5.61 -0.3 4.34e-8 Bone mineral density (hip); CRC cis rs2304069 0.545 rs7728248 chr5:149394965 A/G cg22760475 chr5:149380129 HMGXB3;TIGD6 0.45 6.6 0.34 1.62e-10 HIV-1 control; CRC cis rs6089584 0.927 rs2296081 chr20:60572663 G/T cg06108461 chr20:60628389 TAF4 -0.71 -12.19 -0.56 1.89e-28 Body mass index; CRC cis rs941873 0.835 rs4246944 chr10:81105684 C/T cg09469691 chr10:81107165 PPIF 0.53 8.55 0.43 4.87e-16 Height; CRC cis rs10504229 0.639 rs2291764 chr8:58142943 A/C cg02725872 chr8:58115012 NA -0.59 -8.17 -0.41 6.75e-15 Developmental language disorder (linguistic errors); CRC trans rs1814175 0.558 rs5025146 chr11:49795724 C/G cg15704280 chr7:45808275 SEPT13 -0.95 -16.74 -0.68 6.19e-46 Height; CRC cis rs55692411 0.537 rs7648652 chr3:50135412 A/C cg05623727 chr3:50126028 RBM5 0.55 7.23 0.37 3.46e-12 Intelligence (multi-trait analysis); CRC cis rs28386778 0.897 rs2665844 chr17:61874455 A/G cg06873352 chr17:61820015 STRADA 0.8 15.3 0.64 2.82e-40 Prudent dietary pattern; CRC cis rs9560113 0.960 rs9560102 chr13:112173825 G/A cg14154082 chr13:112174009 NA 0.35 5.71 0.3 2.59e-8 Menarche (age at onset); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg05778706 chr10:101372151 SLC25A28 0.53 7.68 0.39 1.84e-13 Response to antipsychotic treatment; CRC cis rs2985684 1.000 rs2147712 chr14:50091684 G/A cg23565292 chr14:50234668 KLHDC2 -0.4 -5.64 -0.3 3.75e-8 Carotid intima media thickness; CRC trans rs10983614 1.000 rs7867776 chr9:120072627 A/G cg14789568 chr1:29508095 SFRS4 0.44 6.05 0.32 3.83e-9 Survival in pancreatic cancer; CRC cis rs7707921 0.767 rs178931 chr5:81575601 T/A cg21483461 chr5:81570383 RPS23 0.36 5.61 0.3 4.31e-8 Breast cancer; CRC cis rs7666738 0.962 rs11932892 chr4:99072967 C/T cg05340658 chr4:99064831 C4orf37 0.5 6.89 0.36 2.76e-11 Colonoscopy-negative controls vs population controls; CRC cis rs2976388 0.506 rs2572902 chr8:143791387 A/G cg20041105 chr8:143859282 LYNX1 0.46 8.24 0.41 4.25e-15 Urinary tract infection frequency; CRC cis rs4363385 0.693 rs4845331 chr1:152982623 A/G cg25856811 chr1:152973957 SPRR3 -0.25 -6.85 -0.35 3.56e-11 Inflammatory skin disease; CRC cis rs7208859 0.673 rs450585 chr17:28951039 G/A cg26176469 chr17:28951361 LRRC37B2 0.53 5.97 0.31 6.13e-9 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs9914988 0.943 rs4795459 chr17:27113726 G/C cg07195577 chr17:27052828 TLCD1 0.42 6.02 0.32 4.64e-9 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs10751667 0.621 rs7394681 chr11:952111 C/T cg06064525 chr11:970664 AP2A2 -0.31 -6.2 -0.32 1.71e-9 Alzheimer's disease (late onset); CRC cis rs12711979 0.509 rs10205540 chr2:3827839 A/G cg17052675 chr2:3827356 NA -0.86 -20.99 -0.76 1.12e-62 Itch intensity from mosquito bite adjusted by bite size; CRC cis rs2976388 0.647 rs2585136 chr8:143812141 A/G cg04969067 chr8:143858791 LYNX1 0.47 7.86 0.4 5.59e-14 Urinary tract infection frequency; CRC cis rs60843830 1.000 rs17714252 chr2:285471 G/A cg25945732 chr2:264204 ACP1;SH3YL1 0.7 11.41 0.53 1.19e-25 Spherical equivalent (joint analysis main effects and education interaction); CRC cis rs3741151 0.881 rs7951174 chr11:73093135 G/C cg17517138 chr11:73019481 ARHGEF17 0.91 7.46 0.38 7.75e-13 GIP levels in response to oral glucose tolerance test (120 minutes); CRC cis rs138880 0.542 rs9616393 chr22:50314809 A/G cg08270630 chr22:50330655 NA 0.5 5.69 0.3 2.81e-8 Schizophrenia; CRC cis rs9487051 0.676 rs9400268 chr6:109600550 C/T cg21918786 chr6:109611834 NA -0.4 -7.03 -0.36 1.16e-11 Reticulocyte fraction of red cells; CRC cis rs4363385 0.747 rs9919333 chr1:152968744 G/T cg25856811 chr1:152973957 SPRR3 -0.26 -7.24 -0.37 3.29e-12 Inflammatory skin disease; CRC cis rs66573146 0.656 rs66517061 chr4:6935163 C/G cg26116260 chr4:7069785 GRPEL1 -0.71 -5.82 -0.31 1.42e-8 Granulocyte percentage of myeloid white cells; CRC cis rs9768139 0.733 rs13309363 chr7:158122179 C/A cg24154853 chr7:158122151 PTPRN2 0.65 10.93 0.52 6.48e-24 Calcium levels; CRC cis rs2882667 0.964 rs67296915 chr5:138301599 C/T cg09476006 chr5:138032270 NA 0.56 9.84 0.48 3.44e-20 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs4819852 1.000 rs1034566 chr22:19984277 C/T cg07821417 chr22:19972146 ARVCF 0.47 6.26 0.33 1.17e-9 Pulse pressure; CRC cis rs5769765 0.817 rs11912619 chr22:50317401 G/A cg02269571 chr22:50332266 NA -0.61 -7.54 -0.38 4.53e-13 Schizophrenia; CRC cis rs870825 0.616 rs7682557 chr4:185640773 A/G cg04058563 chr4:185651563 MLF1IP 0.73 9.54 0.47 3.32e-19 Blood protein levels; CRC cis rs317865 0.737 rs73234629 chr4:16169776 G/A cg04764131 chr4:16228633 TAPT1;FLJ39653 0.63 5.72 0.3 2.4e-8 Kidney disease (early stage) in type 1 diabetes; CRC cis rs12701220 0.948 rs10275712 chr7:1082918 G/A cg02733842 chr7:1102375 C7orf50 -0.71 -8.32 -0.42 2.42e-15 Bronchopulmonary dysplasia; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg08028037 chr13:52027479 INTS6 0.39 5.97 0.31 6.08e-9 Liver disease severity in Alagille syndrome; CRC cis rs3749237 0.595 rs11130199 chr3:49538799 T/C cg02487422 chr3:49467188 NICN1 0.42 6.9 0.36 2.6e-11 Resting heart rate; CRC cis rs7113874 0.589 rs7949017 chr11:8492127 C/T cg02811074 chr11:8615871 STK33 0.36 6.15 0.32 2.24e-9 Body mass index in physically active individuals;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs2721195 0.967 rs748193 chr8:145682115 C/T cg15320075 chr8:145703422 NA 0.67 11.04 0.52 2.63e-24 Age at first birth; CRC cis rs12024301 0.557 rs9633306 chr1:183638352 C/T cg11505048 chr1:183622726 RGL1;APOBEC4 0.79 6.97 0.36 1.72e-11 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs2976388 0.609 rs2572904 chr8:143792193 A/C cg04969067 chr8:143858791 LYNX1 0.45 7.58 0.39 3.66e-13 Urinary tract infection frequency; CRC cis rs7715806 0.500 rs72633986 chr5:75006449 T/A cg19683494 chr5:74908142 NA 0.51 5.76 0.3 1.89e-8 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs7918232 1.000 rs6482595 chr10:27380261 A/G cg14442939 chr10:27389572 ANKRD26 -0.73 -8.74 -0.43 1.23e-16 Breast cancer; CRC cis rs2836974 0.932 rs8128734 chr21:40569511 G/A cg11890956 chr21:40555474 PSMG1 1.09 18.67 0.72 1.44e-53 Cognitive function; CRC cis rs1215050 0.791 rs165252 chr4:98758728 A/C cg05340658 chr4:99064831 C4orf37 0.47 6.88 0.35 3.09e-11 Waist-to-hip ratio adjusted for body mass index; CRC cis rs6088580 0.713 rs1884669 chr20:33171287 G/A cg24642439 chr20:33292090 TP53INP2 0.4 6.98 0.36 1.61e-11 Glomerular filtration rate (creatinine); CRC trans rs941408 0.515 rs12610096 chr19:2778129 C/T cg22153745 chr1:153894579 GATAD2B -0.57 -7.45 -0.38 8.54e-13 Total cholesterol levels; CRC cis rs7615952 0.599 rs7652883 chr3:125707977 T/G cg02772935 chr3:125709198 NA -0.48 -5.79 -0.3 1.6e-8 Blood pressure (smoking interaction); CRC cis rs9443645 0.869 rs9361489 chr6:79816785 T/C cg09184832 chr6:79620586 NA -0.5 -9.03 -0.45 1.46e-17 Intelligence (multi-trait analysis); CRC cis rs9399135 0.816 rs4134030 chr6:135354094 G/T cg22676075 chr6:135203613 NA 0.4 6.23 0.32 1.41e-9 Red blood cell count; CRC cis rs2286885 1.000 rs2286886 chr9:129246177 T/C cg15282417 chr9:129245246 FAM125B 0.46 8.39 0.42 1.49e-15 Intraocular pressure; CRC cis rs4964805 0.913 rs11111793 chr12:104198118 G/T cg02344784 chr12:104178138 NT5DC3 0.5 7.05 0.36 1.03e-11 Attention deficit hyperactivity disorder; CRC cis rs172166 0.516 rs1150670 chr6:28130559 A/G cg23161317 chr6:28129485 ZNF389 0.39 5.85 0.31 1.17e-8 Cardiac Troponin-T levels; CRC cis rs968567 0.559 rs174548 chr11:61571348 C/G cg00603274 chr11:61596626 FADS2 -0.47 -6.72 -0.35 8.18e-11 Blood metabolite levels;Rheumatoid arthritis;Vitiligo;Glycerophospholipid levels; CRC cis rs730775 0.505 rs325001 chr6:44270936 A/G cg21130236 chr6:44246755 TMEM151B 0.4 6.27 0.33 1.15e-9 Monocyte percentage of white cells;Monocyte count; CRC cis rs9372498 0.536 rs62424195 chr6:118812108 T/A cg24463073 chr6:118973353 C6orf204 0.52 6.9 0.36 2.6e-11 Diastolic blood pressure; CRC cis rs17592366 0.517 rs1967722 chr14:35285274 A/G cg09327582 chr14:35236912 BAZ1A 0.48 6.71 0.35 8.66e-11 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells; CRC cis rs7618915 0.547 rs34017441 chr3:52742413 T/C cg18404041 chr3:52824283 ITIH1 -0.44 -8.9 -0.44 3.72e-17 Bipolar disorder; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg11978387 chr20:52824404 PFDN4 0.48 6.97 0.36 1.76e-11 Response to antipsychotic treatment; CRC cis rs11252926 0.673 rs7096559 chr10:499188 C/T cg03684893 chr10:554711 DIP2C -0.35 -5.89 -0.31 9.66e-9 Psychosis in Alzheimer's disease; CRC cis rs853679 0.517 rs35193936 chr6:28076270 A/G cg15786705 chr6:28176104 NA 0.76 9.6 0.47 2.1e-19 Depression; CRC cis rs453301 0.686 rs1045527 chr8:8890041 A/G cg14979609 chr8:8086686 FLJ10661 0.38 6.3 0.33 9.8e-10 Joint mobility (Beighton score); CRC cis rs172166 0.694 rs203892 chr6:28067196 T/C cg12172441 chr6:28176163 NA 0.53 7.32 0.37 1.96e-12 Cardiac Troponin-T levels; CRC cis rs6424115 0.830 rs2502995 chr1:24199290 T/C cg09473613 chr1:24152604 HMGCL 0.34 5.61 0.3 4.32e-8 Immature fraction of reticulocytes; CRC cis rs4727027 0.635 rs12111923 chr7:148885877 G/A cg23583168 chr7:148888333 NA -0.75 -11.04 -0.52 2.63e-24 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC cis rs17767392 0.645 rs17767296 chr14:71686784 A/T cg13720639 chr14:72061746 SIPA1L1 -0.53 -6.85 -0.35 3.74e-11 Mitral valve prolapse; CRC cis rs977987 0.872 rs10781976 chr16:75314838 G/T cg03315344 chr16:75512273 CHST6 0.51 8.79 0.44 8.62e-17 Dupuytren's disease; CRC cis rs9393777 0.513 rs9393739 chr6:26646966 T/G cg12292205 chr6:26970375 C6orf41 -0.61 -6.99 -0.36 1.52e-11 Intelligence (multi-trait analysis); CRC cis rs1552244 1.000 rs6442146 chr3:10073544 C/T cg18598329 chr3:10140678 FANCD2;C3orf24 -0.89 -12.67 -0.57 3.24e-30 Alzheimer's disease; CRC cis rs951366 0.873 rs823118 chr1:205723572 C/T cg14159672 chr1:205819179 PM20D1 0.44 6.48 0.34 3.44e-10 Menarche (age at onset); CRC cis rs7772486 0.719 rs7753770 chr6:146066161 G/A cg05347473 chr6:146136440 FBXO30 -0.39 -5.86 -0.31 1.13e-8 Lobe attachment (rater-scored or self-reported); CRC cis rs7267979 0.844 rs2424703 chr20:25270124 G/A cg24626310 chr20:25276739 ABHD12;PYGB 0.34 5.77 0.3 1.88e-8 Liver enzyme levels (alkaline phosphatase); CRC cis rs7945705 0.902 rs7479407 chr11:9023421 C/T cg21881798 chr11:8931708 C11orf17;ST5 0.62 9.45 0.46 6.33e-19 Hemoglobin concentration; CRC trans rs916888 0.821 rs199513 chr17:44856932 A/G cg07870213 chr5:140052090 DND1 -0.77 -9.2 -0.45 4.16e-18 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs2243480 0.711 rs2420172 chr7:65635341 T/C cg25985355 chr7:65971099 NA 0.52 6.01 0.31 4.92e-9 Diabetic kidney disease; CRC cis rs7762018 0.655 rs2184194 chr6:170148394 C/T cg24289452 chr6:170231220 NA -0.57 -6.39 -0.33 5.75e-10 Thiazide-induced adverse metabolic effects in hypertensive patients; CRC cis rs4731207 0.596 rs7778875 chr7:124645446 G/A cg23710748 chr7:124431027 NA -0.39 -6.25 -0.33 1.24e-9 Cutaneous malignant melanoma; CRC trans rs1814175 0.817 rs28502006 chr11:50049930 T/C cg11707556 chr5:10655725 ANKRD33B -0.42 -8.03 -0.4 1.75e-14 Height; CRC cis rs17092148 0.836 rs4911157 chr20:33167075 T/C cg08999081 chr20:33150536 PIGU 0.51 6.21 0.32 1.6e-9 Neuroticism; CRC cis rs9896052 0.591 rs7212620 chr17:73461930 A/T cg21038819 chr17:73507788 CASKIN2 0.4 6.28 0.33 1.06e-9 Sight-threatening diabetic retinopathy in type 2 diabetes; CRC cis rs28386778 0.897 rs2854213 chr17:61945631 T/C cg23090583 chr17:61904693 PSMC5;FTSJ3 1.03 19.61 0.73 2.81e-57 Prudent dietary pattern; CRC cis rs769267 0.896 rs10405625 chr19:19579046 T/G cg02546618 chr19:19431379 KIAA0892;SF4 0.45 6.19 0.32 1.78e-9 Tonsillectomy; CRC cis rs9905704 0.647 rs2286299 chr17:57043367 T/G cg12560992 chr17:57184187 TRIM37 0.62 9.5 0.46 4.61e-19 Testicular germ cell tumor; CRC cis rs10751667 0.666 rs7395321 chr11:940280 C/T cg06064525 chr11:970664 AP2A2 -0.31 -6.16 -0.32 2.18e-9 Alzheimer's disease (late onset); CRC cis rs7731657 0.537 rs4705907 chr5:130191437 T/A cg08523029 chr5:130500466 HINT1 -0.46 -5.86 -0.31 1.11e-8 Fasting plasma glucose; CRC cis rs1448094 0.512 rs6539927 chr12:86244486 T/C cg19622623 chr12:86230825 RASSF9 -0.41 -6.68 -0.35 1.01e-10 Major depressive disorder; CRC cis rs10504229 0.683 rs35889486 chr8:58117749 T/A cg02725872 chr8:58115012 NA -0.64 -11.55 -0.54 3.85e-26 Developmental language disorder (linguistic errors); CRC cis rs57221529 0.766 rs17563576 chr5:560476 A/G cg14541582 chr5:601475 NA -0.31 -6.34 -0.33 7.49e-10 Lung disease severity in cystic fibrosis; CRC cis rs8060686 0.641 rs12445396 chr16:68155121 G/A cg08314208 chr16:67682810 RLTPR -0.58 -6.23 -0.32 1.47e-9 HDL cholesterol;Metabolic syndrome; CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg21985132 chr20:42086626 SFRS6 0.43 7.38 0.38 1.27e-12 Obesity-related traits; CRC cis rs7618915 0.547 rs11714419 chr3:52628816 A/G cg18099408 chr3:52552593 STAB1 -0.46 -7.59 -0.39 3.23e-13 Bipolar disorder; CRC cis rs17711722 0.701 rs4467826 chr7:65368708 A/G cg05627663 chr7:65219948 SNORA22;CCT6P1 0.5 7.49 0.38 6.37e-13 Calcium levels; CRC cis rs9902453 0.904 rs7212292 chr17:28409264 T/C cg26525008 chr17:28256777 EFCAB5;SSH2 -0.69 -11.39 -0.53 1.45e-25 Coffee consumption (cups per day); CRC cis rs1707322 0.682 rs10890335 chr1:46100394 G/C cg06784218 chr1:46089804 CCDC17 0.65 12.37 0.56 3.93e-29 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs7044106 0.791 rs7036766 chr9:123479621 G/A cg09419670 chr9:123605666 PSMD5;LOC253039 0.75 12.09 0.55 4.22e-28 Hip circumference adjusted for BMI; CRC cis rs992157 0.798 rs10193383 chr2:219157692 C/T cg00012203 chr2:219082015 ARPC2 0.46 6.92 0.36 2.36e-11 Colorectal cancer; CRC cis rs7945705 0.806 rs12224436 chr11:8815825 C/A cg21881798 chr11:8931708 C11orf17;ST5 0.48 7.19 0.37 4.31e-12 Hemoglobin concentration; CRC cis rs3820928 0.904 rs2396432 chr2:227765891 C/T cg11843606 chr2:227700838 RHBDD1 -0.41 -5.94 -0.31 7.15e-9 Pulmonary function; CRC cis rs17021463 0.844 rs17311008 chr4:95274653 A/G cg11021082 chr4:95130006 SMARCAD1 0.48 7.25 0.37 3.08e-12 Testicular germ cell tumor; CRC cis rs7044106 0.718 rs10616 chr9:123363533 T/C cg09419670 chr9:123605666 PSMD5;LOC253039 0.65 10.42 0.5 3.63e-22 Hip circumference adjusted for BMI; CRC cis rs2013441 1.000 rs11870147 chr17:20216095 A/G cg13482628 chr17:19912719 NA -0.41 -6.31 -0.33 9.14e-10 Obesity-related traits; CRC cis rs11212617 0.967 rs4987982 chr11:108151269 G/A cg12106634 chr11:108092400 ATM;NPAT 0.39 5.68 0.3 2.98e-8 Response to metformin in type 2 diabetes (glycemic); CRC trans rs12599106 0.770 rs12445057 chr16:34970274 C/G cg21548813 chr6:291882 DUSP22 -0.66 -9.51 -0.46 4.23e-19 Menopause (age at onset); CRC cis rs860295 0.702 rs10908472 chr1:155544256 T/C cg02153340 chr1:155202674 NA -0.58 -6.75 -0.35 6.59e-11 Body mass index; CRC cis rs6502050 0.805 rs4789721 chr17:80157453 T/C cg13198984 chr17:80129470 CCDC57 0.42 7.33 0.37 1.77e-12 Life satisfaction; CRC trans rs2303319 0.504 rs1023835 chr2:162593973 A/G cg22627826 chr19:1240265 ATP5D -0.72 -6.24 -0.33 1.32e-9 Cognitive function; CRC cis rs2932538 0.922 rs11102508 chr1:113141175 T/C cg22162597 chr1:113214053 CAPZA1 0.61 9.1 0.45 8.84e-18 Systolic blood pressure;Diastolic blood pressure;Hypertension;Blood pressure; CRC cis rs62064224 0.714 rs11657299 chr17:30634951 G/A cg25833597 chr17:30823145 MYO1D 0.34 5.64 0.3 3.7e-8 Schizophrenia; CRC cis rs9393692 0.620 rs9379844 chr6:26291527 A/G cg00631329 chr6:26305371 NA 0.55 9.29 0.46 2.1e-18 Educational attainment; CRC cis rs4862750 0.872 rs7658314 chr4:187900356 T/C cg03452623 chr4:187889614 NA -0.92 -22.45 -0.78 2.37e-68 Lobe attachment (rater-scored or self-reported); CRC cis rs9911578 1.000 rs304292 chr17:56824123 G/A cg05425664 chr17:57184151 TRIM37 -0.48 -7.6 -0.39 3.02e-13 Intelligence (multi-trait analysis); CRC cis rs8060686 0.920 rs1124324 chr16:67897487 C/T cg07125278 chr16:67683757 RLTPR -0.56 -6.53 -0.34 2.5e-10 HDL cholesterol;Metabolic syndrome; CRC cis rs600231 0.542 rs10896009 chr11:65246054 A/G cg17120908 chr11:65337727 SSSCA1 0.68 7.43 0.38 9.66e-13 Bone mineral density; CRC cis rs394563 0.591 rs237028 chr6:149718650 C/T cg11245181 chr6:149772854 ZC3H12D -0.53 -9.31 -0.46 1.89e-18 Dupuytren's disease; CRC cis rs172166 0.516 rs1225710 chr6:28100640 C/T cg03623178 chr6:28175578 NA -0.68 -10.39 -0.5 4.69e-22 Cardiac Troponin-T levels; CRC cis rs2580764 0.624 rs12713284 chr2:55228861 G/A cg09592903 chr2:55203963 RTN4 -0.74 -11.89 -0.55 2.3e-27 Mean platelet volume; CRC cis rs72945132 1.000 rs72945129 chr11:70110808 C/T cg00319359 chr11:70116639 PPFIA1 0.68 6.55 0.34 2.2e-10 Coronary artery disease; CRC trans rs7937682 0.855 rs521947 chr11:111492616 A/G cg18187862 chr3:45730750 SACM1L 0.45 6.55 0.34 2.23e-10 Primary sclerosing cholangitis; CRC trans rs6703335 0.870 rs10803142 chr1:243598234 A/G cg22515636 chr2:109150313 NA 0.44 6.24 0.33 1.34e-9 Schizophrenia;Schizophrenia, schizoaffective disorder or bipolar disorder; CRC trans rs7976838 0.831 rs2222878 chr12:60135228 G/A cg16974014 chr22:22007515 MIR130B 0.49 6.0 0.31 5.21e-9 Response to zileuton treatment in asthma (FEV1 change interaction); CRC cis rs877282 0.945 rs11253398 chr10:790012 T/C cg06581033 chr10:766294 NA -0.51 -5.68 -0.3 2.97e-8 Uric acid levels; CRC cis rs7618915 0.547 rs11130313 chr3:52676190 A/C cg08222913 chr3:52553049 STAB1 -0.34 -6.14 -0.32 2.4e-9 Bipolar disorder; CRC cis rs7208859 0.673 rs9912122 chr17:29140716 C/A cg14008862 chr17:28927542 LRRC37B2 0.51 6.01 0.31 4.88e-9 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs6694672 0.702 rs6685259 chr1:197093098 A/T cg13682187 chr1:196946512 CFHR5 0.58 7.96 0.4 2.83e-14 Asthma; CRC cis rs1865760 0.602 rs2157050 chr6:26020431 C/T cg16482183 chr6:26056742 HIST1H1C 0.53 7.79 0.39 9.12e-14 Height; CRC cis rs8177179 0.967 rs4287912 chr3:133437778 A/G cg24879335 chr3:133465180 TF 0.42 8.17 0.41 6.89e-15 Iron status biomarkers (transferrin levels); CRC cis rs6693567 0.565 rs1260408 chr1:150307270 T/G cg15654264 chr1:150340011 RPRD2 0.41 6.06 0.32 3.79e-9 Migraine; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg01869960 chr2:136289456 R3HDM1;ZRANB3 0.5 6.91 0.36 2.52e-11 Response to antipsychotic treatment; CRC cis rs7618915 0.501 rs13085775 chr3:52678370 C/T cg15147215 chr3:52552868 STAB1 -0.64 -11.05 -0.52 2.42e-24 Bipolar disorder; CRC cis rs9372498 0.536 rs9481833 chr6:118919631 G/A cg24463073 chr6:118973353 C6orf204 0.51 6.73 0.35 7.61e-11 Diastolic blood pressure; CRC cis rs10256972 0.732 rs1574108 chr7:1105805 T/C cg22907277 chr7:1156413 C7orf50 0.5 7.16 0.37 5.22e-12 Longevity;Endometriosis; CRC trans rs57506017 0.517 rs10488192 chr7:12277081 G/A cg26461140 chr11:72811902 FCHSD2 0.58 6.51 0.34 2.83e-10 Neuroticism; CRC cis rs477895 0.713 rs11607165 chr11:63963947 T/G cg04317338 chr11:64019027 PLCB3 0.6 7.36 0.38 1.45e-12 Mean platelet volume; CRC cis rs2479724 0.901 rs10947987 chr6:41754370 C/T cg17623882 chr6:41773611 USP49 0.53 8.83 0.44 6.21e-17 Menarche (age at onset); CRC cis rs644799 1.000 rs586498 chr11:95537828 C/T cg25478527 chr11:95522999 CEP57;FAM76B 0.51 7.69 0.39 1.68e-13 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs2070677 1.000 rs2070677 chr10:135351174 A/T cg16964102 chr10:135390573 NA 0.48 6.76 0.35 6.23e-11 Gout; CRC cis rs568617 0.767 rs2231884 chr11:65656564 C/T cg26695010 chr11:65641043 EFEMP2 -0.56 -5.76 -0.3 1.92e-8 Crohn's disease; CRC cis rs4713118 0.513 rs202908 chr6:28011551 C/G cg23161317 chr6:28129485 ZNF389 0.45 6.38 0.33 6.09e-10 Parkinson's disease; CRC cis rs826838 0.904 rs10880981 chr12:38763911 G/A cg26384229 chr12:38710491 ALG10B 0.75 10.56 0.5 1.25e-22 Heart rate; CRC cis rs2651899 0.867 rs2742675 chr1:3079905 A/G cg22674798 chr1:3096360 PRDM16 0.35 7.42 0.38 1.02e-12 Migraine; CRC cis rs8060686 0.623 rs7204208 chr16:68069416 A/G cg26727032 chr16:67993705 SLC12A4 -0.65 -9.76 -0.47 6.4e-20 HDL cholesterol;Metabolic syndrome; CRC cis rs6582630 0.555 rs34730221 chr12:38405140 C/T cg26384229 chr12:38710491 ALG10B -0.65 -9.69 -0.47 1.06e-19 Drug-induced liver injury (flucloxacillin); CRC cis rs2075165 0.838 rs12072638 chr1:156267480 T/G cg20302342 chr1:156215951 PAQR6 0.37 7.21 0.37 3.91e-12 Tonsillectomy; CRC trans rs10242455 0.557 rs73403272 chr7:99134208 T/G cg09045935 chr12:6379348 NA 1.07 8.56 0.43 4.37e-16 Blood metabolite levels; CRC cis rs12477438 0.798 rs1349778 chr2:99645011 G/C cg26064155 chr2:99771622 LIPT1;TSGA10 -0.73 -10.18 -0.49 2.41e-21 Chronic sinus infection; CRC cis rs3785574 0.745 rs2854162 chr17:61975610 T/C cg23090583 chr17:61904693 PSMC5;FTSJ3 -0.65 -9.05 -0.45 1.25e-17 Height; CRC cis rs7223966 0.921 rs6504186 chr17:61863932 G/A cg23090583 chr17:61904693 PSMC5;FTSJ3 0.51 6.27 0.33 1.16e-9 Hip circumference adjusted for BMI;Body mass index; CRC cis rs11997175 0.967 rs60586868 chr8:33776585 A/G ch.8.33884649F chr8:33765107 NA 0.42 6.2 0.32 1.67e-9 Body mass index; CRC cis rs9549367 0.826 rs9549710 chr13:113898064 A/C cg00898013 chr13:113819073 PROZ -0.46 -6.51 -0.34 2.78e-10 Platelet distribution width; CRC cis rs9649213 0.593 rs736754 chr7:97931559 C/T cg24562669 chr7:97807699 LMTK2 0.42 7.01 0.36 1.36e-11 Prostate cancer (SNP x SNP interaction); CRC cis rs8180040 0.932 rs12490058 chr3:47529063 T/C cg02527881 chr3:46936655 PTH1R -0.41 -7.84 -0.4 6.52e-14 Colorectal cancer; CRC cis rs4332037 0.539 rs11762545 chr7:2060775 C/T cg02825527 chr7:2087843 MAD1L1 -0.47 -5.71 -0.3 2.51e-8 Bipolar disorder; CRC cis rs62244186 0.541 rs62244226 chr3:44831831 G/A cg10263370 chr3:44754102 ZNF502 -0.36 -6.08 -0.32 3.35e-9 Depressive symptoms; CRC cis rs2836950 0.509 rs4816618 chr21:40599529 G/A cg11644478 chr21:40555479 PSMG1 -0.51 -7.58 -0.39 3.48e-13 Menarche (age at onset); CRC cis rs801193 1.000 rs2659906 chr7:66165310 T/C cg25985355 chr7:65971099 NA -0.32 -5.62 -0.3 3.97e-8 Aortic root size; CRC cis rs13178541 0.551 rs4315919 chr5:135108794 G/A cg10179196 chr5:134915088 CXCL14 -0.34 -5.91 -0.31 8.37e-9 IgG glycosylation; CRC cis rs35883536 0.967 rs9433740 chr1:101133985 G/A cg14515779 chr1:101123966 NA 0.36 6.62 0.34 1.45e-10 Monocyte count; CRC trans rs916888 0.773 rs199448 chr17:44809001 A/G cg10053473 chr17:62856997 LRRC37A3 -0.81 -9.05 -0.45 1.26e-17 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs2228479 0.850 rs11641147 chr16:89813589 C/T cg19635926 chr16:89946313 TCF25 0.66 5.97 0.31 6.1e-9 Skin colour saturation; CRC trans rs7726839 0.574 rs12522955 chr5:639231 C/A cg11887960 chr12:57824829 NA 0.59 6.59 0.34 1.79e-10 Obesity-related traits; CRC cis rs12900413 0.687 rs28513927 chr15:90304471 T/G cg24249390 chr15:90295951 MESP1 -0.57 -8.97 -0.44 2.34e-17 Coronary artery aneurysm in Kawasaki disease; CRC cis rs7666738 0.753 rs1527520 chr4:98929164 A/G cg05340658 chr4:99064831 C4orf37 0.6 9.35 0.46 1.41e-18 Colonoscopy-negative controls vs population controls; CRC cis rs9487051 0.768 rs351752 chr6:109536034 C/A cg21918786 chr6:109611834 NA -0.36 -6.18 -0.32 1.85e-9 Reticulocyte fraction of red cells; CRC cis rs2307022 0.586 rs3785123 chr16:68386581 C/T cg02226672 chr16:68398533 SMPD3 0.28 5.64 0.3 3.74e-8 Body mass index; CRC cis rs7811142 1.000 rs7809801 chr7:100072031 T/C cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.91 12.27 0.56 9.02e-29 Platelet count; CRC cis rs875971 0.571 rs78668714 chr7:65939451 G/A cg05627663 chr7:65219948 SNORA22;CCT6P1 0.59 7.5 0.38 5.94e-13 Aortic root size; CRC cis rs3768617 0.868 rs2296299 chr1:183104013 G/A ch.1.3577855R chr1:183094577 LAMC1 0.62 9.38 0.46 1.11e-18 Fuchs's corneal dystrophy; CRC cis rs270601 0.913 rs273899 chr5:131695178 G/A cg04518342 chr5:131593106 PDLIM4 0.43 7.04 0.36 1.14e-11 Acylcarnitine levels; CRC cis rs7552404 0.960 rs61797339 chr1:76189946 G/T cg10523679 chr1:76189770 ACADM 0.84 11.73 0.54 9.02e-27 Blood metabolite levels;Acylcarnitine levels; CRC cis rs7617773 0.817 rs17647717 chr3:48305456 C/T cg11946769 chr3:48343235 NME6 0.72 9.45 0.46 6.54e-19 Coronary artery disease; CRC cis rs9916302 0.851 rs7220650 chr17:37487168 A/G cg15445000 chr17:37608096 MED1 -0.43 -9.78 -0.47 5.21e-20 Glomerular filtration rate (creatinine); CRC cis rs733592 0.524 rs10875741 chr12:48492922 A/C cg21466736 chr12:48725269 NA 0.51 8.01 0.4 1.96e-14 Plateletcrit; CRC cis rs910316 0.967 rs4384542 chr14:75658013 A/C cg08847533 chr14:75593920 NEK9 -0.85 -14.91 -0.64 8.87e-39 Height; CRC cis rs12630931 1.000 rs11714920 chr3:31972205 G/C cg21375017 chr3:31988082 OSBPL10 0.44 6.06 0.32 3.68e-9 Periodontal disease-related phenotypes; CRC cis rs4713118 0.696 rs2394002 chr6:27748015 G/A cg15845792 chr6:28175446 NA 0.68 8.97 0.44 2.28e-17 Parkinson's disease; CRC cis rs17270561 0.583 rs12662869 chr6:25784481 A/C cg16482183 chr6:26056742 HIST1H1C -0.61 -8.39 -0.42 1.49e-15 Iron status biomarkers; CRC cis rs10197940 0.710 rs4500942 chr2:152334580 A/G cg19508488 chr2:152266495 RIF1 0.61 8.89 0.44 4.25e-17 Lung cancer; CRC cis rs4481887 0.962 rs12037921 chr1:248454167 T/G cg13385794 chr1:248469461 NA 0.38 6.69 0.35 9.77e-11 Common traits (Other); CRC cis rs6424115 0.708 rs13551 chr1:24180962 T/C cg10978503 chr1:24200527 CNR2 -0.44 -6.77 -0.35 6.02e-11 Immature fraction of reticulocytes; CRC cis rs4713118 0.615 rs9348772 chr6:27656090 G/T cg15786705 chr6:28176104 NA 0.41 5.84 0.31 1.26e-8 Parkinson's disease; CRC cis rs6076065 0.692 rs2424549 chr20:23394563 C/A cg11657817 chr20:23433608 CST11 0.43 6.33 0.33 8.11e-10 Facial morphology (factor 15, philtrum width); CRC cis rs4919694 0.572 rs12262258 chr10:104900272 G/A cg04362960 chr10:104952993 NT5C2 0.88 9.11 0.45 8.21e-18 Arsenic metabolism; CRC cis rs1862618 0.853 rs252922 chr5:56136343 G/T cg22800045 chr5:56110881 MAP3K1 0.56 6.15 0.32 2.29e-9 Initial pursuit acceleration; CRC cis rs10504229 0.954 rs114134184 chr8:58181969 G/A cg22535103 chr8:58192502 C8orf71 -0.82 -12.27 -0.56 9.63e-29 Developmental language disorder (linguistic errors); CRC trans rs1814175 0.645 rs1608632 chr11:49967148 C/T cg11707556 chr5:10655725 ANKRD33B -0.53 -10.07 -0.49 5.92e-21 Height; CRC cis rs7527798 0.637 rs7515149 chr1:207838352 T/G cg21110645 chr1:207815933 NA -0.43 -6.64 -0.34 1.26e-10 Erythrocyte sedimentation rate; CRC cis rs6500602 0.673 rs4786513 chr16:4576423 T/C cg14951292 chr16:4525986 HMOX2;NMRAL1 0.65 9.43 0.46 7.82e-19 Schizophrenia; CRC trans rs6703335 0.870 rs10803142 chr1:243598234 A/G cg06698420 chr6:107437230 NA 0.42 6.04 0.32 4.07e-9 Schizophrenia;Schizophrenia, schizoaffective disorder or bipolar disorder; CRC cis rs11690935 0.655 rs1028127 chr2:172530036 T/C cg13550731 chr2:172543902 DYNC1I2 0.68 10.14 0.49 3.29e-21 Schizophrenia; CRC cis rs780096 0.526 rs12476704 chr2:27613031 C/A cg27432699 chr2:27873401 GPN1 -0.61 -9.25 -0.45 2.84e-18 Total body bone mineral density; CRC cis rs807029 0.758 rs807025 chr10:102764821 C/T cg04662943 chr10:102668895 NA 0.66 7.74 0.39 1.27e-13 Ejection fraction in Tripanosoma cruzi seropositivity; CRC trans rs2303319 0.504 rs1515182 chr2:162436934 A/G cg14875682 chr5:52083620 ITGA1;PELO -0.75 -6.01 -0.31 5.03e-9 Cognitive function; CRC cis rs7044106 0.791 rs4617229 chr9:123480696 A/G cg09419670 chr9:123605666 PSMD5;LOC253039 0.71 11.84 0.55 3.63e-27 Hip circumference adjusted for BMI; CRC cis rs4437462 1.000 rs4437462 chr6:11310419 A/G cg25250968 chr6:11318770 NEDD9 0.42 6.1 0.32 3.04e-9 HIV-1 susceptibility; CRC cis rs2836950 0.520 rs8133928 chr21:40689963 G/A cg06238570 chr21:40685208 BRWD1 -0.6 -8.64 -0.43 2.48e-16 Menarche (age at onset); CRC cis rs17125944 0.505 rs75661138 chr14:53259262 G/A cg00686598 chr14:53173677 PSMC6 1.25 11.62 0.54 2.11e-26 Alzheimer's disease (late onset); CRC cis rs6011002 0.808 rs2738787 chr20:62328375 A/G cg01176363 chr20:62369445 LIME1 -0.75 -5.73 -0.3 2.29e-8 Dental caries; CRC trans rs7267979 0.873 rs6083853 chr20:25404541 T/C cg17903999 chr18:56338584 MALT1 0.4 6.54 0.34 2.32e-10 Liver enzyme levels (alkaline phosphatase); CRC cis rs875971 0.522 rs1701760 chr7:65473688 A/G cg02869306 chr7:64672164 INTS4L1 -0.36 -6.05 -0.32 3.96e-9 Aortic root size; CRC cis rs7647973 0.922 rs57273516 chr3:49483074 A/G cg20833759 chr3:49053208 WDR6;DALRD3 0.55 8.47 0.42 8.41e-16 Menarche (age at onset); CRC cis rs67478160 0.609 rs6576003 chr14:104291330 C/A cg01849466 chr14:104193079 ZFYVE21 -0.53 -10.06 -0.48 6.34e-21 Schizophrenia; CRC cis rs477895 0.653 rs2015226 chr11:63902534 C/T cg05016508 chr11:63871570 FLRT1;MACROD1 0.53 6.83 0.35 4.22e-11 Mean platelet volume; CRC cis rs7772486 0.790 rs2256998 chr6:146207657 A/C cg13319975 chr6:146136371 FBXO30 -0.4 -6.14 -0.32 2.32e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs11252926 0.574 rs4881313 chr10:487973 C/T cg18196295 chr10:418757 DIP2C -0.43 -6.29 -0.33 1.01e-9 Psychosis in Alzheimer's disease; CRC cis rs1223397 1.000 rs1223399 chr6:13271220 G/A cg21538684 chr6:13274180 PHACTR1 0.46 5.67 0.3 3.06e-8 Blood pressure; CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg08187779 chr8:102217898 ZNF706 0.41 7.02 0.36 1.29e-11 Obesity-related traits; CRC cis rs7737355 1.000 rs7737355 chr5:130604811 T/A cg06307176 chr5:131281290 NA 0.38 5.6 0.3 4.48e-8 Life satisfaction; CRC cis rs12134245 0.776 rs12122066 chr1:92005140 C/T cg21854759 chr1:92012499 NA -0.53 -8.64 -0.43 2.51e-16 Breast cancer; CRC cis rs11750568 0.933 rs7719616 chr5:178536584 A/G cg10208897 chr5:178548229 ADAMTS2 0.35 5.74 0.3 2.13e-8 Height; CRC cis rs4285028 0.948 rs1920309 chr3:121665479 G/A cg20356878 chr3:121714668 ILDR1 -0.47 -6.92 -0.36 2.32e-11 Multiple sclerosis; CRC trans rs61931739 0.534 rs4547187 chr12:34041259 T/C cg26384229 chr12:38710491 ALG10B 0.47 6.36 0.33 6.58e-10 Morning vs. evening chronotype; CRC cis rs1401999 0.836 rs34571027 chr3:183726644 T/C cg01324343 chr3:183735012 ABCC5 0.77 13.81 0.61 1.61e-34 Anterior chamber depth; CRC cis rs853679 0.517 rs9393886 chr6:28050039 T/G cg12172441 chr6:28176163 NA 0.6 7.27 0.37 2.64e-12 Depression; CRC cis rs853679 0.550 rs1233699 chr6:28169158 A/T cg21251018 chr6:28226885 NKAPL 0.48 6.9 0.36 2.69e-11 Depression; CRC cis rs4332037 0.552 rs11773627 chr7:2002733 A/G cg21155852 chr7:2048760 MAD1L1 -0.45 -6.42 -0.33 4.85e-10 Bipolar disorder; CRC cis rs736408 0.812 rs2270197 chr3:52824095 T/G cg18404041 chr3:52824283 ITIH1 -0.53 -10.35 -0.5 6.5600000000000005e-22 Bipolar disorder; CRC trans rs10504229 0.906 rs111838497 chr8:58185620 A/C cg04077850 chr5:125800366 GRAMD3 0.37 6.27 0.33 1.15e-9 Developmental language disorder (linguistic errors); CRC cis rs10193935 0.901 rs13393459 chr2:42463124 C/T cg27598129 chr2:42591480 NA -0.7 -7.87 -0.4 5.16e-14 Colonoscopy-negative controls vs population controls; CRC cis rs11723261 0.582 rs114199753 chr4:163520 G/C cg12746427 chr4:53362 ZNF718;ZNF595 0.52 7.23 0.37 3.46e-12 Immune response to smallpox vaccine (IL-6); CRC cis rs6500602 0.855 rs2304631 chr16:4475868 A/T cg08645402 chr16:4508243 NA 0.53 7.56 0.38 3.97e-13 Schizophrenia; CRC trans rs10983614 1.000 rs7867776 chr9:120072627 A/G cg20994686 chr17:71306668 CDC42EP4 0.47 6.56 0.34 2.07e-10 Survival in pancreatic cancer; CRC cis rs7208859 0.573 rs56031503 chr17:29075665 T/C cg13385521 chr17:29058706 SUZ12P 0.71 8.1 0.41 1.05e-14 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs17067123 0.539 rs11735192 chr4:180065076 A/C cg26610307 chr4:180072759 NA -0.57 -6.84 -0.35 3.85e-11 Response to hepatitis C treatment; CRC cis rs7769051 1.000 rs58832890 chr6:133127139 C/T cg22852734 chr6:133119734 C6orf192 1.06 13.05 0.58 1.14e-31 Type 2 diabetes nephropathy; CRC cis rs2257205 0.667 rs4340382 chr17:56738919 G/A cg25885038 chr17:56607967 SEPT4 -0.52 -5.69 -0.3 2.87e-8 Pancreatic cancer; CRC cis rs6831352 0.879 rs1230154 chr4:99988659 C/T cg12011299 chr4:100065546 ADH4 0.52 10.38 0.5 4.91e-22 Alcohol dependence; CRC cis rs7666738 0.791 rs1426661 chr4:98874303 C/G cg05340658 chr4:99064831 C4orf37 0.56 8.33 0.42 2.21e-15 Colonoscopy-negative controls vs population controls; CRC cis rs1707322 1.000 rs9803784 chr1:46401907 T/C cg03146154 chr1:46216737 IPP 0.5 7.07 0.36 9.58e-12 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs2882667 0.898 rs2351465 chr5:138363851 A/C cg04439458 chr5:138467593 SIL1 -0.33 -6.08 -0.32 3.36e-9 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs910316 1.000 rs12897094 chr14:75579416 C/T cg08847533 chr14:75593920 NEK9 0.92 17.38 0.69 1.9e-48 Height; CRC cis rs875971 0.545 rs6460298 chr7:65907770 T/C cg03233332 chr7:66118400 NA -0.43 -5.95 -0.31 7.02e-9 Aortic root size; CRC cis rs929354 0.566 rs6979947 chr7:157005863 C/T cg16102536 chr7:156981717 UBE3C -0.46 -7.83 -0.4 6.83e-14 Body mass index; CRC cis rs875971 0.505 rs1167385 chr7:65513308 G/A cg00343986 chr7:65444356 GUSB -0.56 -8.5 -0.42 6.79e-16 Aortic root size; CRC cis rs1862618 0.853 rs832565 chr5:56150803 T/G cg12311346 chr5:56204834 C5orf35 -0.79 -10.4 -0.5 4.39e-22 Initial pursuit acceleration; CRC cis rs992157 0.835 rs34353396 chr2:219153982 T/C cg04880052 chr2:219191631 PNKD -0.44 -6.95 -0.36 1.94e-11 Colorectal cancer; CRC trans rs951252 0.504 rs11734405 chr4:146081096 C/T cg00402069 chr5:89770788 POLR3G;MBLAC2 0.49 6.2 0.32 1.67e-9 Hip circumference; CRC cis rs10504229 0.639 rs67002486 chr8:58117218 A/G cg04204079 chr8:58130323 NA -0.45 -5.78 -0.3 1.71e-8 Developmental language disorder (linguistic errors); CRC cis rs1320333 0.772 rs35181861 chr2:679483 A/G cg20966539 chr2:681320 NA 0.66 5.92 0.31 8.14e-9 Obesity-related traits; CRC cis rs9733 0.526 rs11204696 chr1:150658721 T/C cg10589385 chr1:150898437 SETDB1 0.29 6.2 0.32 1.7e-9 Tonsillectomy; CRC cis rs780096 0.526 rs11126999 chr2:27670307 G/A cg12648201 chr2:27665141 KRTCAP3 -0.32 -6.15 -0.32 2.29e-9 Total body bone mineral density; CRC cis rs727563 0.580 rs202626 chr22:41847190 C/A cg06634786 chr22:41940651 POLR3H 0.54 6.65 0.34 1.21e-10 Crohn's disease;Inflammatory bowel disease; CRC trans rs1376359 0.673 rs12755707 chr1:103138940 A/G cg16220183 chr17:56609687 SEPT4 -0.44 -6.07 -0.32 3.44e-9 QRS duration in Tripanosoma cruzi seropositivity; CRC cis rs9611565 0.694 rs19573 chr22:41865809 C/A cg03806693 chr22:41940476 POLR3H 1.03 14.51 0.62 3.08e-37 Vitiligo; CRC cis rs950169 0.800 rs4099846 chr15:84956894 C/G cg17507749 chr15:85114479 UBE2QP1 0.74 10.59 0.5 9.91e-23 Schizophrenia; CRC trans rs2303319 0.504 rs12473088 chr2:162485073 A/G cg12500891 chr11:57225987 NA -0.69 -6.05 -0.32 4.05e-9 Cognitive function; CRC trans rs853679 1.000 rs68141011 chr6:28217797 G/T cg06606381 chr12:133084897 FBRSL1 -0.74 -7.05 -0.36 1.08e-11 Depression; CRC cis rs727505 0.789 rs4731233 chr7:124736291 C/T cg23710748 chr7:124431027 NA -0.72 -12.28 -0.56 8.92e-29 Lewy body disease; CRC trans rs1814175 0.817 rs7947526 chr11:49983654 T/C cg15704280 chr7:45808275 SEPT13 -0.97 -18.5 -0.71 6.8e-53 Height; CRC cis rs40363 0.680 rs72778116 chr16:3530752 A/G cg21433313 chr16:3507492 NAT15 0.61 5.64 0.3 3.75e-8 Tuberculosis; CRC cis rs9443645 0.835 rs1044309 chr6:79646575 A/G cg09184832 chr6:79620586 NA -0.5 -9.27 -0.46 2.45e-18 Intelligence (multi-trait analysis); CRC cis rs4975616 0.804 rs31489 chr5:1342714 C/A cg26373071 chr5:1325741 CLPTM1L 0.46 8.12 0.41 9.42e-15 Lung cancer; CRC cis rs4843747 0.671 rs74729706 chr16:88104159 C/T cg03395651 chr16:88107091 BANP 0.61 8.18 0.41 6.46e-15 Menopause (age at onset); CRC cis rs9326248 1.000 rs664922 chr11:117070895 C/A cg11861562 chr11:117069780 TAGLN 0.42 9.39 0.46 1.07e-18 Blood protein levels; CRC cis rs7772486 0.754 rs4896841 chr6:146041522 T/C cg13319975 chr6:146136371 FBXO30 0.45 6.58 0.34 1.84e-10 Lobe attachment (rater-scored or self-reported); CRC cis rs4713118 0.662 rs9468275 chr6:28026136 G/T cg02683197 chr6:28174875 NA 0.75 9.8 0.48 4.46e-20 Parkinson's disease; CRC cis rs6433857 0.594 rs1950029 chr2:181520566 G/C cg23363182 chr2:181467187 NA -0.48 -7.38 -0.38 1.3e-12 Body mass index; CRC cis rs1552244 0.572 rs17032426 chr3:10167112 G/A cg16606324 chr3:10149918 C3orf24 0.66 7.74 0.39 1.19e-13 Alzheimer's disease; CRC cis rs2836974 0.897 rs34599551 chr21:40594898 C/A cg06238570 chr21:40685208 BRWD1 0.73 10.29 0.49 1.01e-21 Cognitive function; CRC cis rs2404602 0.684 rs157759 chr15:76846990 T/A cg03037974 chr15:76606532 NA 0.51 7.93 0.4 3.53e-14 Blood metabolite levels; CRC trans rs875971 0.660 rs2191268 chr7:66110224 C/T cg09423085 chr2:68478351 PPP3R1 -0.4 -6.2 -0.32 1.69e-9 Aortic root size; CRC cis rs12134245 0.747 rs17501512 chr1:92012481 C/G cg25838465 chr1:92012736 NA 0.66 12.18 0.56 2.04e-28 Breast cancer; CRC cis rs734999 0.588 rs60520190 chr1:2533706 G/A cg18854424 chr1:2615690 NA 0.42 8.06 0.41 1.41e-14 Ulcerative colitis; CRC cis rs7927771 1.000 rs34128973 chr11:47851376 C/T cg05585544 chr11:47624801 NA -0.61 -10.84 -0.51 1.25e-23 Subjective well-being; CRC cis rs1552244 0.882 rs67895180 chr3:10026079 T/C cg13047869 chr3:10149882 C3orf24 0.51 6.91 0.36 2.54e-11 Alzheimer's disease; CRC cis rs1552244 0.832 rs3732968 chr3:10013273 A/G cg18598329 chr3:10140678 FANCD2;C3orf24 -0.81 -10.63 -0.51 6.98e-23 Alzheimer's disease; CRC trans rs10504229 1.000 rs67546820 chr8:58168567 G/A cg04077850 chr5:125800366 GRAMD3 0.36 6.15 0.32 2.22e-9 Developmental language disorder (linguistic errors); CRC cis rs17767392 0.681 rs4902922 chr14:71688207 G/C cg13720639 chr14:72061746 SIPA1L1 -0.52 -6.68 -0.35 1.03e-10 Mitral valve prolapse; CRC cis rs4713118 0.869 rs6914924 chr6:27711530 C/T cg20933634 chr6:27740509 NA 0.58 8.5 0.42 6.74e-16 Parkinson's disease; CRC cis rs1044826 0.642 rs6771831 chr3:139177585 C/T cg00490450 chr3:139108681 COPB2 0.43 6.43 0.33 4.49e-10 Obesity-related traits; CRC cis rs2404602 0.735 rs4886805 chr15:76739384 A/G cg03037974 chr15:76606532 NA 0.54 7.88 0.4 4.7e-14 Blood metabolite levels; CRC cis rs4713118 0.824 rs2092075 chr6:27749330 G/C cg08798685 chr6:27730294 NA -0.48 -6.66 -0.34 1.12e-10 Parkinson's disease; CRC cis rs2908197 0.806 rs12534035 chr7:75980946 G/C cg10167463 chr7:75959203 YWHAG -0.4 -5.92 -0.31 7.94e-9 3-hydroxypropylmercapturic acid levels in smokers; CRC cis rs7811142 0.830 rs6965458 chr7:99973402 G/A cg00814883 chr7:100076585 TSC22D4 -0.72 -8.62 -0.43 2.83e-16 Platelet count; CRC cis rs1904096 0.506 rs11097408 chr4:95165662 T/C cg11021082 chr4:95130006 SMARCAD1 -0.52 -8.08 -0.41 1.28e-14 Type 2 diabetes; CRC cis rs10982256 0.774 rs10817623 chr9:117244937 G/A cg13636371 chr9:117264095 DFNB31 -0.31 -5.64 -0.3 3.75e-8 Bipolar disorder; CRC cis rs6952808 0.789 rs35729895 chr7:1885069 C/T cg21782813 chr7:2030301 MAD1L1 0.39 6.78 0.35 5.54e-11 Bipolar disorder and schizophrenia; CRC trans rs2303319 0.504 rs72873624 chr2:162481453 G/A cg18122310 chr12:50236657 BCDIN3D -0.73 -6.17 -0.32 2.02e-9 Cognitive function; CRC cis rs2836974 0.865 rs7282624 chr21:40667040 C/T cg17971929 chr21:40555470 PSMG1 0.81 11.47 0.53 7.41e-26 Cognitive function; CRC cis rs9733 0.596 rs12077833 chr1:150674333 C/T cg17724175 chr1:150552817 MCL1 0.6 9.61 0.47 2.03e-19 Tonsillectomy; CRC trans rs916888 0.610 rs199442 chr17:44820122 G/A cg22968622 chr17:43663579 NA 0.92 12.7 0.57 2.35e-30 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs7726839 0.561 rs3915384 chr5:573395 G/T cg09021430 chr5:549028 NA -0.84 -11.03 -0.52 2.82e-24 Obesity-related traits; CRC cis rs2760061 0.598 rs658238 chr1:228121291 A/G cg02753203 chr1:228287806 NA -0.64 -9.82 -0.48 3.92e-20 Diastolic blood pressure; CRC cis rs17270561 0.609 rs4712959 chr6:25727057 C/T cg16482183 chr6:26056742 HIST1H1C 0.83 10.59 0.5 9.49e-23 Iron status biomarkers; CRC cis rs561341 0.505 rs548298 chr17:30297494 C/A cg23018236 chr17:30244563 NA -0.57 -7.48 -0.38 6.78e-13 Hip circumference adjusted for BMI; CRC cis rs2239547 0.563 rs9839035 chr3:52909877 C/T cg18404041 chr3:52824283 ITIH1 -0.36 -6.72 -0.35 7.85e-11 Schizophrenia; CRC cis rs11098499 0.775 rs10029303 chr4:120286755 T/A cg24375607 chr4:120327624 NA 0.48 7.48 0.38 6.72e-13 Corneal astigmatism; CRC cis rs10463316 0.894 rs12153347 chr5:150765471 C/T cg03212797 chr5:150827313 SLC36A1 -0.49 -7.6 -0.39 3.11e-13 Metabolite levels (Pyroglutamine); CRC cis rs11628318 0.853 rs6575925 chr14:103034507 C/T cg23461800 chr14:103021989 NA -0.75 -10.07 -0.49 5.61e-21 Platelet count; CRC cis rs13256369 0.802 rs1060107 chr8:8561399 G/T cg06636001 chr8:8085503 FLJ10661 0.48 6.1 0.32 2.99e-9 Obesity-related traits; CRC cis rs13191362 0.935 rs13215748 chr6:163010710 A/C cg23758597 chr6:163146217 PARK2 -0.55 -6.12 -0.32 2.7e-9 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs10504229 0.953 rs6990806 chr8:58183113 G/A cg01721255 chr8:58191610 C8orf71 0.49 6.17 0.32 2e-9 Developmental language disorder (linguistic errors); CRC cis rs5751150 1 rs5751150 chr22:42153292 T/G cg06634786 chr22:41940651 POLR3H 0.66 7.29 0.37 2.28e-12 Cannabis dependence symptom count; CRC cis rs67340775 0.541 rs200964 chr6:27866943 G/C cg25164649 chr6:28176230 NA 0.6 6.15 0.32 2.27e-9 Lung cancer in ever smokers; CRC cis rs2535633 0.602 rs2581816 chr3:53014657 C/T cg15147215 chr3:52552868 STAB1 -0.4 -6.41 -0.33 5.19e-10 Body mass index; CRC cis rs1552244 0.816 rs17050701 chr3:10041554 A/G cg10729496 chr3:10149963 C3orf24 0.49 6.34 0.33 7.69e-10 Alzheimer's disease; CRC cis rs7584330 0.744 rs10929234 chr2:238380034 C/G cg11271282 chr2:238384023 NA -0.48 -5.76 -0.3 1.97e-8 Prostate cancer; CRC cis rs926392 0.589 rs2019032 chr20:37680326 C/A cg16355469 chr20:37678765 NA 0.48 7.17 0.37 4.84e-12 Dialysis-related mortality; CRC cis rs4662945 0.688 rs62174140 chr2:130202893 C/T cg05903289 chr2:130345205 NA -0.3 -5.78 -0.3 1.74e-8 Response to cytidine analogues (gemcitabine); CRC cis rs6570726 0.791 rs1935612 chr6:145906090 T/A cg23711669 chr6:146136114 FBXO30 0.65 10.83 0.51 1.44e-23 Lobe attachment (rater-scored or self-reported); CRC cis rs172166 0.561 rs149971 chr6:27982152 G/A cg15786705 chr6:28176104 NA 0.48 7.05 0.36 1.05e-11 Cardiac Troponin-T levels; CRC cis rs72945132 0.882 rs67093918 chr11:70198999 C/A cg00319359 chr11:70116639 PPFIA1 0.55 6.04 0.32 4.16e-9 Coronary artery disease; CRC cis rs8177179 0.967 rs6439436 chr3:133453779 C/T cg24879335 chr3:133465180 TF -0.48 -9.54 -0.47 3.31e-19 Iron status biomarkers (transferrin levels); CRC cis rs8180040 0.900 rs10865946 chr3:47425060 T/G cg27129171 chr3:47204927 SETD2 0.52 8.07 0.41 1.38e-14 Colorectal cancer; CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg00906435 chr17:2304368 MNT 0.38 6.3 0.33 9.38e-10 Obesity-related traits; CRC cis rs1218582 0.682 rs12144978 chr1:154850445 G/A cg24250549 chr1:154909240 PMVK 0.57 8.52 0.43 5.72e-16 Prostate cancer; CRC cis rs4664293 0.967 rs3940435 chr2:160494783 G/A cg08347373 chr2:160653686 CD302 -0.44 -7.22 -0.37 3.61e-12 Monocyte percentage of white cells; CRC cis rs9287719 0.614 rs10929679 chr2:10723108 C/T cg00105475 chr2:10696890 NA 0.45 7.07 0.36 9.46e-12 Prostate cancer; CRC cis rs6951245 0.706 rs28685743 chr7:1197736 C/T cg20603222 chr7:1096387 C7orf50;GPR146 -0.62 -7.61 -0.39 2.95e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs9549367 0.789 rs2302754 chr13:113898385 C/T cg18105134 chr13:113819100 PROZ 0.72 10.25 0.49 1.43e-21 Platelet distribution width; CRC cis rs11250464 0.833 rs2387653 chr10:1407826 A/G cg26394196 chr10:1453818 ADARB2 0.34 6.0 0.31 5.07e-9 Radiation response; CRC cis rs35146811 0.735 rs2272344 chr7:99786819 C/T cg13334819 chr7:99746414 C7orf59 -0.51 -6.72 -0.35 7.79e-11 Coronary artery disease; CRC trans rs1814175 0.645 rs6486022 chr11:49776137 A/G cg11707556 chr5:10655725 ANKRD33B -0.51 -9.76 -0.47 6.37e-20 Height; CRC cis rs9372498 0.536 rs9481833 chr6:118919631 G/A cg22561889 chr6:118971681 C6orf204 0.5 6.39 0.33 5.8e-10 Diastolic blood pressure; CRC cis rs9308731 0.583 rs7567184 chr2:111931072 C/G cg04202892 chr2:111875749 ACOXL 0.42 6.75 0.35 6.53e-11 Chronic lymphocytic leukemia; CRC cis rs7726839 0.507 rs111707179 chr5:593308 T/A cg14541582 chr5:601475 NA -0.36 -7.38 -0.38 1.32e-12 Obesity-related traits; CRC cis rs2734839 0.964 rs2234690 chr11:113291748 T/A cg14159747 chr11:113255604 NA 0.46 8.1 0.41 1.12e-14 Information processing speed; CRC cis rs4319547 0.695 rs7969429 chr12:122875606 A/G cg05707623 chr12:122985044 ZCCHC8 -0.73 -8.76 -0.44 1.02e-16 Body mass index; CRC cis rs2811415 0.597 rs11714256 chr3:127804368 G/A cg13719885 chr3:127795394 NA -0.4 -5.92 -0.31 8.11e-9 Lung function (FEV1/FVC); CRC cis rs1552244 0.816 rs13059144 chr3:10010197 A/C cg02579736 chr3:10068473 FANCD2;CIDECP 0.93 12.02 0.55 7.57e-28 Alzheimer's disease; CRC cis rs4665809 1.000 rs10182857 chr2:26344411 C/T cg25036284 chr2:26402008 FAM59B -0.46 -5.97 -0.31 6e-9 Gut microbiome composition (summer); CRC cis rs7811142 0.720 rs7795656 chr7:99950297 A/T cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.93 12.56 0.57 8.16e-30 Platelet count; CRC cis rs977987 0.872 rs4887816 chr16:75319716 T/C cg03315344 chr16:75512273 CHST6 0.54 9.03 0.45 1.5e-17 Dupuytren's disease; CRC cis rs4713118 0.824 rs2092075 chr6:27749330 G/C cg12273811 chr6:28175739 NA 0.5 6.63 0.34 1.38e-10 Parkinson's disease; CRC cis rs12142240 0.698 rs68083747 chr1:46807416 T/G cg14993813 chr1:46806288 NSUN4 -0.49 -6.22 -0.32 1.5e-9 Menopause (age at onset); CRC cis rs780096 0.546 rs1060525 chr2:27635582 A/G cg22903471 chr2:27725779 GCKR -0.37 -6.05 -0.32 3.92e-9 Total body bone mineral density; CRC cis rs2658782 0.789 rs1456238 chr11:93117370 G/C cg15737290 chr11:93063684 CCDC67 0.45 6.57 0.34 1.95e-10 Pulmonary function decline; CRC cis rs1559088 0.847 rs2287679 chr19:33600764 T/C cg27124370 chr19:33622961 WDR88 0.44 6.12 0.32 2.64e-9 Bone ultrasound measurement (broadband ultrasound attenuation); CRC cis rs2243480 1.000 rs1167613 chr7:65487439 C/T cg12463550 chr7:65579703 CRCP 0.7 6.44 0.33 4.33e-10 Diabetic kidney disease; CRC cis rs3741151 0.773 rs73548693 chr11:73286637 G/A cg17517138 chr11:73019481 ARHGEF17 0.96 7.46 0.38 8.01e-13 GIP levels in response to oral glucose tolerance test (120 minutes); CRC trans rs1346081 0.786 rs1425645 chr4:68028175 C/T cg13685329 chr2:73460476 CCT7;C2orf7 0.51 6.21 0.32 1.64e-9 Intelligence (multi-trait analysis); CRC cis rs1799949 0.929 rs799905 chr17:41277187 G/C cg25072359 chr17:41440525 NA 0.52 8.3 0.42 2.68e-15 Menopause (age at onset); CRC cis rs600806 0.850 rs7518013 chr1:109944078 C/T cg23032129 chr1:109941072 SORT1 0.27 5.84 0.31 1.24e-8 Intelligence (multi-trait analysis); CRC trans rs8005150 0.737 rs74074328 chr14:88490211 G/A cg25527770 chr19:1444892 NA -0.59 -6.43 -0.33 4.47e-10 Hepatitis B; CRC cis rs561341 1.000 rs72825740 chr17:30338356 A/G cg12193833 chr17:30244370 NA -0.75 -8.76 -0.44 1.01e-16 Hip circumference adjusted for BMI; CRC cis rs9733 0.596 rs11803569 chr1:150664077 C/T cg15448220 chr1:150897856 SETDB1 0.45 6.43 0.33 4.42e-10 Tonsillectomy; CRC cis rs17756712 0.667 rs2073006 chr6:637465 C/T cg16786516 chr6:604617 EXOC2 0.51 6.49 0.34 3.09e-10 Vertical cup-disc ratio; CRC cis rs9400271 0.632 rs9398192 chr6:109587236 C/T cg01475377 chr6:109611718 NA -0.35 -6.1 -0.32 3e-9 Sum neutrophil eosinophil counts;Sum basophil neutrophil counts;White blood cell count;Neutrophil count;Myeloid white cell count;Granulocyte count; CRC cis rs9303401 1.000 rs1390006 chr17:56890663 C/T cg02118635 chr17:56770003 RAD51C;TEX14 -0.54 -7.98 -0.4 2.49e-14 Cognitive test performance; CRC cis rs7666738 0.830 rs34628820 chr4:99004764 C/T cg17366294 chr4:99064904 C4orf37 0.44 7.39 0.38 1.19e-12 Colonoscopy-negative controls vs population controls; CRC cis rs2839186 0.771 rs13046451 chr21:47641373 T/A cg08742575 chr21:47604166 C21orf56 -0.36 -5.63 -0.3 3.96e-8 Testicular germ cell tumor; CRC cis rs11758351 1.000 rs16891378 chr6:26188864 A/G cg22723502 chr6:26240528 HIST1H4F -0.36 -5.68 -0.3 2.94e-8 Gout;Renal underexcretion gout; CRC cis rs8062405 1.000 rs62036617 chr16:28827498 T/C cg16576597 chr16:28551801 NUPR1 0.49 7.07 0.36 9.42e-12 Cognitive ability (multi-trait analysis);Cognitive ability; CRC cis rs9287719 0.967 rs6432113 chr2:10744889 C/T cg00105475 chr2:10696890 NA -0.44 -7.12 -0.37 6.9e-12 Prostate cancer; CRC cis rs896854 0.846 rs13254283 chr8:95914103 G/T cg16049864 chr8:95962084 TP53INP1 -0.63 -11.01 -0.52 3.29e-24 Type 2 diabetes; CRC cis rs6089829 1.000 rs6089829 chr20:61669036 C/T cg03213289 chr20:61660250 NA -0.33 -6.74 -0.35 7.26e-11 Prostate cancer (SNP x SNP interaction); CRC cis rs875971 0.862 rs778680 chr7:65840414 G/A cg12463550 chr7:65579703 CRCP 0.5 6.98 0.36 1.65e-11 Aortic root size; CRC cis rs9488822 0.636 rs1544155 chr6:116346394 C/A cg26893134 chr6:116381904 FRK 0.28 8.08 0.41 1.21e-14 Cholesterol, total;LDL cholesterol; CRC cis rs10256972 0.621 rs10951594 chr7:1088607 C/G cg26608667 chr7:1196370 ZFAND2A 0.35 5.67 0.3 3.1e-8 Longevity;Endometriosis; CRC cis rs17023223 0.553 rs56234947 chr1:119707744 G/A cg05756136 chr1:119680316 WARS2 -0.53 -7.13 -0.37 6.41e-12 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for BMI in active individuals; CRC cis rs11098499 0.863 rs1383532 chr4:120434404 A/T cg24375607 chr4:120327624 NA -0.48 -7.37 -0.38 1.37e-12 Corneal astigmatism; CRC cis rs4478858 0.684 rs7549245 chr1:31752187 A/G cg00250761 chr1:31883323 NA -0.43 -8.37 -0.42 1.68e-15 Alcohol dependence; CRC cis rs7809950 0.954 rs2712193 chr7:107125885 A/C cg23024343 chr7:107201750 COG5 -0.6 -8.59 -0.43 3.44e-16 Coronary artery disease; CRC cis rs460214 0.576 rs28446127 chr21:40029568 C/A cg05519781 chr21:40033154 ERG -0.42 -5.72 -0.3 2.43e-8 Response to cognitive-behavioural therapy in anxiety disorder; CRC cis rs1639906 0.893 rs13233298 chr7:2227707 C/T cg19897017 chr7:2163380 MAD1L1 0.57 8.34 0.42 2.03e-15 Colonoscopy-negative controls vs population controls; CRC trans rs11098499 0.954 rs10034623 chr4:120397829 G/A cg25214090 chr10:38739885 LOC399744 0.64 10.34 0.5 7.18e-22 Corneal astigmatism; CRC cis rs1799949 1.000 rs11654731 chr17:41326940 G/A cg19454999 chr17:41278357 BRCA1;NBR2 0.54 8.25 0.41 3.98e-15 Menopause (age at onset); CRC cis rs240764 0.604 rs9404016 chr6:101177728 G/A cg09795085 chr6:101329169 ASCC3 0.42 5.81 0.31 1.44e-8 Neuroticism; CRC cis rs4731207 0.565 rs1031959 chr7:124627313 T/C cg23710748 chr7:124431027 NA -0.39 -6.17 -0.32 1.96e-9 Cutaneous malignant melanoma; CRC trans rs9929218 0.677 rs12597188 chr16:68814826 G/A cg04657470 chr2:198365150 HSPE1;HSPD1 -0.77 -10.53 -0.5 1.53e-22 Colorectal cancer; CRC cis rs2952156 0.920 rs9303274 chr17:37836353 T/C cg00129232 chr17:37814104 STARD3 -0.71 -12.58 -0.57 6.95e-30 Asthma; CRC cis rs72945132 0.825 rs7941965 chr11:70213182 T/C cg00319359 chr11:70116639 PPFIA1 0.59 6.61 0.34 1.6e-10 Coronary artery disease; CRC cis rs13064411 0.735 rs13098166 chr3:113210038 A/G cg10517650 chr3:113235015 CCDC52 -0.41 -7.18 -0.37 4.55e-12 Response to simvastatin treatment (PCSK9 protein level change); CRC cis rs738322 0.935 rs75387 chr22:38572057 C/T cg17652424 chr22:38574118 PLA2G6 -0.22 -6.83 -0.35 4.12e-11 Cutaneous nevi; CRC cis rs7894407 0.760 rs4917386 chr10:105007528 C/T cg05636881 chr10:105038444 INA -0.38 -6.07 -0.32 3.5e-9 White matter hyperintensity burden; CRC cis rs11971779 0.680 rs2355788 chr7:139101897 T/C cg23387468 chr7:139079360 LUC7L2 0.41 7.05 0.36 1.04e-11 Diisocyanate-induced asthma; CRC cis rs769267 0.965 rs8103496 chr19:19386015 A/G cg01262667 chr19:19385393 TM6SF2 0.36 5.87 0.31 1.06e-8 Tonsillectomy; CRC cis rs780096 0.526 rs780112 chr2:27665361 C/G cg24768116 chr2:27665128 KRTCAP3 -0.36 -8.21 -0.41 5.02e-15 Total body bone mineral density; CRC cis rs9303280 0.628 rs12939565 chr17:38038389 A/T cg11212589 chr17:38028394 ZPBP2 0.46 8.78 0.44 9.42e-17 Self-reported allergy; CRC cis rs3858526 0.635 rs2045046 chr11:5875867 A/C cg26762873 chr11:5879799 OR52E8 -0.43 -6.18 -0.32 1.85e-9 DNA methylation (variation); CRC cis rs1577917 0.958 rs36042496 chr6:86524214 G/A cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.49 -6.58 -0.34 1.82e-10 Response to antipsychotic treatment; CRC cis rs6586163 0.934 rs7897395 chr10:90754607 T/C cg13456138 chr10:90753195 FAS -0.43 -6.63 -0.34 1.38e-10 Chronic lymphocytic leukemia; CRC cis rs7772486 0.806 rs2265477 chr6:146212338 T/C cg23711669 chr6:146136114 FBXO30 0.66 11.43 0.53 1.06e-25 Lobe attachment (rater-scored or self-reported); CRC cis rs2932538 0.922 rs6668533 chr1:113064468 C/T cg22162597 chr1:113214053 CAPZA1 0.71 9.94 0.48 1.51e-20 Systolic blood pressure;Diastolic blood pressure;Hypertension;Blood pressure; CRC trans rs853679 0.546 rs200995 chr6:27813694 C/T cg16898833 chr6:26189333 HIST1H4D -0.68 -6.1 -0.32 2.96e-9 Depression; CRC cis rs7666738 0.753 rs10004827 chr4:99037953 A/C cg05340658 chr4:99064831 C4orf37 0.6 9.45 0.46 6.36e-19 Colonoscopy-negative controls vs population controls; CRC cis rs12530845 0.623 rs73721673 chr7:135349573 A/T cg23117316 chr7:135346802 PL-5283 -0.5 -6.43 -0.33 4.5e-10 Red blood cell traits; CRC cis rs4819052 0.851 rs10470258 chr21:46658989 C/T cg02159808 chr21:46707872 POFUT2;LOC642852 0.49 6.41 0.33 5.19e-10 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg10062221 chr8:37962833 ASH2L 0.45 6.39 0.33 5.68e-10 Response to antipsychotic treatment; CRC cis rs2832191 0.716 rs2692625 chr21:30446360 C/G cg08807101 chr21:30365312 RNF160 0.71 11.57 0.54 3.39e-26 Dental caries; CRC cis rs11105298 0.891 rs3741898 chr12:89933763 G/C cg00757033 chr12:89920650 WDR51B 0.38 6.28 0.33 1.06e-9 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg03457587 chr19:54694791 MBOAT7;TSEN34 0.48 6.8 0.35 5.06e-11 Response to antipsychotic treatment; CRC cis rs9914988 1.000 rs9914988 chr17:27183104 G/A cg12682573 chr17:27188876 MIR451;MIR144 -0.6 -8.79 -0.44 8.51e-17 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs4974559 0.739 rs10012819 chr4:1324758 G/C cg02980000 chr4:1222292 CTBP1 0.78 8.68 0.43 1.91e-16 Systolic blood pressure; CRC cis rs17001868 0.568 rs9611329 chr22:40792038 G/T cg07138101 chr22:40742427 ADSL 0.53 7.32 0.37 1.97e-12 Mammographic density (dense area); CRC cis rs4713118 0.513 rs149942 chr6:28001610 T/C cg12273811 chr6:28175739 NA 0.55 8.14 0.41 8.09e-15 Parkinson's disease; CRC cis rs1150668 0.745 rs213238 chr6:28321993 T/C cg06470822 chr6:28175283 NA 0.59 8.66 0.43 2.23e-16 Pubertal anthropometrics; CRC cis rs763121 0.853 rs2413547 chr22:39107338 A/G cg06022373 chr22:39101656 GTPBP1 0.78 12.18 0.56 1.98e-28 Menopause (age at onset); CRC cis rs1555322 0.530 rs2425047 chr20:33871675 G/T cg13662093 chr20:33865505 NA -0.43 -6.16 -0.32 2.17e-9 Attention deficit hyperactivity disorder; CRC cis rs447 0.806 rs6467987 chr7:83756215 C/T cg22846510 chr7:83753280 SEMA3A -0.42 -5.73 -0.3 2.27e-8 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs2243480 1.000 rs6974723 chr7:65637939 C/T cg12463550 chr7:65579703 CRCP -0.71 -6.52 -0.34 2.61e-10 Diabetic kidney disease; CRC cis rs7493 0.853 rs6973380 chr7:95043523 C/T cg17330251 chr7:94953956 PON1 -0.56 -7.42 -0.38 9.76e-13 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs1223397 0.651 rs2919686 chr6:13312641 A/G cg07912922 chr6:13274314 PHACTR1 0.38 6.0 0.31 5.21e-9 Blood pressure; CRC cis rs76878669 0.561 rs2279862 chr11:66135179 C/T cg24851651 chr11:66362959 CCS -0.39 -6.77 -0.35 6.08e-11 Educational attainment (years of education); CRC cis rs597539 0.654 rs655816 chr11:68626405 A/G cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.86 14.54 0.63 2.44e-37 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs6762477 0.715 rs12631337 chr3:50198537 A/G cg24110177 chr3:50126178 RBM5 0.45 6.81 0.35 4.66e-11 Menarche (age at onset); CRC trans rs6561151 0.681 rs7989702 chr13:44439150 T/C cg12856521 chr11:46389249 DGKZ 0.73 10.56 0.5 1.21e-22 Crohn's disease; CRC cis rs7618915 0.501 rs6617 chr3:52740182 C/G cg08222913 chr3:52553049 STAB1 -0.32 -5.93 -0.31 7.82e-9 Bipolar disorder; CRC cis rs6951245 1.000 rs79422648 chr7:1080241 T/C cg26224354 chr7:1096374 C7orf50;GPR146 -0.89 -11.19 -0.53 7.61e-25 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs1448094 0.511 rs4559760 chr12:86149414 G/A cg06740227 chr12:86229804 RASSF9 -0.37 -5.64 -0.3 3.71e-8 Major depressive disorder; CRC cis rs7781266 0.948 rs2346264 chr7:133536351 A/C cg03336402 chr7:133662267 EXOC4 -0.59 -7.43 -0.38 9.37e-13 Educational attainment (college completion); CRC cis rs10927875 0.557 rs1572381 chr1:16344494 G/A cg10494257 chr1:16342123 HSPB7 0.46 6.37 0.33 6.52e-10 Dilated cardiomyopathy; CRC cis rs7584330 0.740 rs13404177 chr2:238441412 T/C cg16989719 chr2:238392110 NA -0.39 -7.95 -0.4 3.07e-14 Prostate cancer; CRC cis rs514406 0.679 rs545719 chr1:53304922 T/C cg25767906 chr1:53392781 SCP2 -0.52 -8.14 -0.41 8.32e-15 Monocyte count; CRC cis rs7762018 1.000 rs7747645 chr6:170070291 G/C cg17545662 chr6:170176663 C6orf70 0.53 5.82 0.31 1.39e-8 Thiazide-induced adverse metabolic effects in hypertensive patients; CRC trans rs1814175 0.869 rs10769600 chr11:49681832 C/T cg15704280 chr7:45808275 SEPT13 -0.98 -18.41 -0.71 1.64e-52 Height; CRC trans rs561341 1.000 rs72825712 chr17:30316119 A/T cg27661571 chr11:113659931 NA -0.97 -11.31 -0.53 2.92e-25 Hip circumference adjusted for BMI; CRC cis rs533581 0.866 rs4995274 chr16:88970040 T/C cg16701003 chr16:89028210 CBFA2T3 0.44 6.9 0.36 2.73e-11 Social autistic-like traits; CRC cis rs6665290 0.901 rs61834005 chr1:227202789 C/T cg10327440 chr1:227177885 CDC42BPA -1.0 -20.8 -0.75 6.04e-62 Myeloid white cell count; CRC cis rs2404602 0.716 rs2164101 chr15:76749117 A/G cg03037974 chr15:76606532 NA 0.75 13.63 0.6 7.48e-34 Blood metabolite levels; CRC cis rs10193935 1.000 rs13399869 chr2:42386041 C/G cg27598129 chr2:42591480 NA -0.65 -7.55 -0.38 4.28e-13 Colonoscopy-negative controls vs population controls; CRC cis rs7618501 0.633 rs2526751 chr3:50064867 T/C cg24308560 chr3:49941425 MST1R 0.5 8.14 0.41 8.11e-15 Intelligence (multi-trait analysis); CRC cis rs282587 0.569 rs1756076 chr13:113395819 T/C cg04656015 chr13:113407548 ATP11A 0.63 7.8 0.4 8.04e-14 Glycated hemoglobin levels; CRC trans rs459571 0.959 rs461462 chr9:136911272 C/T cg09836344 chr4:1243392 C4orf42;CTBP1 -0.78 -11.13 -0.52 1.25e-24 Platelet distribution width; CRC cis rs1218582 0.772 rs7528532 chr1:154874440 C/T cg03351412 chr1:154909251 PMVK 0.54 8.68 0.43 1.92e-16 Prostate cancer; CRC cis rs1008375 1.000 rs2315560 chr4:17677305 C/G cg16339924 chr4:17578868 LAP3 0.5 6.55 0.34 2.27e-10 Parasitemia in Tripanosoma cruzi seropositivity; CRC trans rs2303319 0.504 rs56153413 chr2:162440079 G/T cg12500891 chr11:57225987 NA -0.67 -6.02 -0.31 4.7e-9 Cognitive function; CRC cis rs1223397 0.651 rs2919685 chr6:13311668 T/C cg20827128 chr6:13274284 PHACTR1 0.37 5.76 0.3 1.96e-8 Blood pressure; CRC cis rs6701037 0.681 rs1057239 chr1:175130204 G/A cg14847009 chr1:175162515 KIAA0040 -0.26 -5.68 -0.3 2.9e-8 Alcohol dependence; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg01125366 chr10:72218306 NA 0.37 6.16 0.32 2.07e-9 Liver disease severity in Alagille syndrome; CRC cis rs9926296 0.605 rs886952 chr16:89836781 G/A cg21285383 chr16:89894308 SPIRE2 0.35 5.97 0.31 6e-9 Vitiligo; CRC cis rs2084637 0.828 rs9633954 chr11:122419907 T/A cg21585512 chr11:122030076 LOC399959 -0.35 -6.5 -0.34 3.05e-10 Stroke; CRC cis rs736801 0.569 rs11748193 chr5:131725329 A/T cg12564285 chr5:131593104 PDLIM4 0.34 5.81 0.3 1.49e-8 Breast cancer;Mosquito bite size; CRC cis rs908922 0.542 rs4845785 chr1:152510143 C/T cg09873164 chr1:152488093 CRCT1 0.4 6.49 0.34 3.08e-10 Hair morphology; CRC trans rs9388451 0.872 rs2008027 chr6:126052359 A/G cg05039488 chr6:79577232 IRAK1BP1 -0.57 -8.62 -0.43 2.86e-16 Brugada syndrome; CRC cis rs858239 1.000 rs166663 chr7:23316742 A/C cg00469287 chr7:23338798 C7orf30 0.46 6.07 0.32 3.51e-9 Cerebrospinal fluid biomarker levels; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg21796443 chr7:4722378 FOXK1 0.43 6.15 0.32 2.3e-9 Intelligence (multi-trait analysis); CRC cis rs12477438 0.520 rs6717729 chr2:99756941 T/C cg14399236 chr2:99771627 LIPT1;TSGA10 0.8 13.9 0.61 7.29e-35 Chronic sinus infection; CRC trans rs1814175 0.645 rs10444311 chr11:49986906 A/G cg03929089 chr4:120376271 NA -0.91 -16.17 -0.67 1.06e-43 Height; CRC cis rs10870270 0.956 rs10870281 chr10:133762642 G/A cg17892150 chr10:133769511 PPP2R2D -0.74 -10.95 -0.52 5.2e-24 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; CRC cis rs977987 0.864 rs37593 chr16:75496907 T/C cg03315344 chr16:75512273 CHST6 -0.58 -9.63 -0.47 1.69e-19 Dupuytren's disease; CRC cis rs13108904 0.901 rs2293634 chr4:1291711 T/G cg15763984 chr4:1342303 KIAA1530 0.33 5.61 0.3 4.38e-8 Obesity-related traits; CRC cis rs611744 0.647 rs647907 chr8:109251374 T/C cg18478394 chr8:109455254 TTC35 0.39 6.03 0.32 4.3e-9 Dupuytren's disease; CRC cis rs7605827 0.866 rs13417550 chr2:15533895 A/G cg19274914 chr2:15703543 NA 0.38 5.75 0.3 2.01e-8 Educational attainment (years of education); CRC cis rs375066 0.935 rs425217 chr19:44393975 C/T cg11993925 chr19:44307056 LYPD5 0.37 5.71 0.3 2.47e-8 Breast cancer; CRC cis rs2976388 0.647 rs2585138 chr8:143808951 C/T cg20041105 chr8:143859282 LYNX1 0.47 8.38 0.42 1.61e-15 Urinary tract infection frequency; CRC cis rs10193935 1.000 rs10190326 chr2:42388262 A/C cg27598129 chr2:42591480 NA 0.61 7.11 0.36 7.46e-12 Colonoscopy-negative controls vs population controls; CRC cis rs2727020 0.523 rs4115783 chr11:49556026 G/A cg25886479 chr11:50257625 LOC441601 0.34 5.63 0.3 3.82e-8 Coronary artery disease; CRC cis rs6502050 0.805 rs7503095 chr17:80107354 G/A cg13198984 chr17:80129470 CCDC57 0.46 8.16 0.41 6.94e-15 Life satisfaction; CRC cis rs7618915 0.501 rs13060048 chr3:52598608 G/A cg15147215 chr3:52552868 STAB1 -0.65 -11.29 -0.53 3.36e-25 Bipolar disorder; CRC cis rs9318086 0.712 rs12875437 chr13:24453956 A/G cg25267304 chr13:24462978 PCOTH;MIPEP 0.62 10.26 0.49 1.32e-21 Myopia (pathological); CRC cis rs616402 0.527 rs11584327 chr1:10578791 T/C cg17425144 chr1:10567563 PEX14 0.58 13.44 0.6 4e-33 Breast size; CRC cis rs9916302 0.904 rs55660616 chr17:37684990 C/A cg00129232 chr17:37814104 STARD3 -0.56 -8.27 -0.41 3.44e-15 Glomerular filtration rate (creatinine); CRC cis rs16975963 0.843 rs73031215 chr19:38433555 G/A cg15135657 chr19:38346511 NA -0.43 -5.75 -0.3 2.01e-8 Longevity; CRC cis rs1545257 0.505 rs12988810 chr2:24635093 G/T cg06627628 chr2:24431161 ITSN2 -0.48 -7.01 -0.36 1.33e-11 Sjögren's syndrome; CRC cis rs1552244 0.515 rs67626468 chr3:10161518 C/A cg16606324 chr3:10149918 C3orf24 0.66 7.7 0.39 1.65e-13 Alzheimer's disease; CRC cis rs7589728 0.563 rs12479338 chr2:88444513 C/T cg24977027 chr2:88469347 THNSL2 0.64 7.72 0.39 1.37e-13 Plasma clusterin levels; CRC cis rs754466 0.874 rs10430531 chr10:79660125 T/C cg17075019 chr10:79541650 NA -0.74 -10.37 -0.5 5.59e-22 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs919433 0.926 rs787996 chr2:198216805 A/G cg03934865 chr2:198174659 NA 0.36 5.85 0.31 1.18e-8 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC cis rs4523957 0.583 rs2760743 chr17:2017079 A/C cg16513277 chr17:2031491 SMG6 0.65 11.02 0.52 3.13e-24 Autism spectrum disorder or schizophrenia;Schizophrenia; CRC cis rs13031619 0.950 rs7589966 chr2:3696636 A/G cg19052272 chr2:3704530 ALLC 0.57 7.72 0.39 1.45e-13 Response to inhaled corticosteroid treatment in asthma (change in FEV1); CRC trans rs1945213 0.694 rs12222077 chr11:55848116 T/A cg03929089 chr4:120376271 NA 0.56 6.35 0.33 7.04e-10 Acute lymphoblastic leukemia (childhood); CRC cis rs17154702 0.510 rs7831224 chr8:8656647 C/T cg01851573 chr8:8652454 MFHAS1 0.44 5.78 0.3 1.71e-8 Neurocognitive impairment in HIV-1 infection (continuous); CRC cis rs17376456 0.542 rs17083380 chr5:93170476 C/G cg25358565 chr5:93447407 FAM172A -0.47 -6.28 -0.33 1.06e-9 Diabetic retinopathy; CRC cis rs9811920 0.809 rs6440967 chr3:99722396 G/T cg07805332 chr3:99536008 MIR548G;C3orf26 -0.4 -6.06 -0.32 3.83e-9 Axial length; CRC cis rs6815814 0.861 rs28393318 chr4:38784267 A/G cg06935464 chr4:38784597 TLR10 0.65 8.29 0.42 3e-15 Breast cancer; CRC cis rs10751667 0.643 rs10902257 chr11:973577 T/C cg01483505 chr11:975446 AP2A2 0.46 7.59 0.39 3.23e-13 Alzheimer's disease (late onset); CRC cis rs1816752 0.774 rs55888616 chr13:25016092 C/T cg02811702 chr13:24901961 NA 0.48 6.66 0.34 1.14e-10 Obesity-related traits; CRC cis rs2019137 0.905 rs2276561 chr2:113956371 G/C cg11763394 chr2:113992921 PAX8;LOC440839;LOC654433 -0.49 -7.07 -0.36 9.28e-12 Lymphocyte counts; CRC cis rs12612619 0.621 rs4665943 chr2:27295885 C/T cg00617064 chr2:27272375 NA 0.39 6.18 0.32 1.91e-9 Venous thromboembolism adjusted for sickle cell variant rs77121243-T; CRC trans rs1814175 0.645 rs11040702 chr11:50024827 C/T cg15704280 chr7:45808275 SEPT13 -0.92 -16.92 -0.68 1.2e-46 Height; CRC cis rs12540874 0.529 rs732215 chr7:50544063 A/C cg18232548 chr7:50535776 DDC -0.55 -8.46 -0.42 8.83e-16 Systemic sclerosis; CRC cis rs7113874 0.550 rs4929949 chr11:8604593 T/C cg20771178 chr11:8615675 STK33 0.35 5.74 0.3 2.17e-8 Body mass index in physically active individuals;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs2692947 0.864 rs2579518 chr2:96675259 G/A cg23100626 chr2:96804247 ASTL 0.26 7.0 0.36 1.41e-11 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; CRC cis rs7493 0.853 rs6973380 chr7:95043523 C/T cg04155289 chr7:94953770 PON1 -0.6 -7.65 -0.39 2.25e-13 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs6933660 0.800 rs13201167 chr6:151773504 T/C cg10883421 chr6:151773342 RMND1;C6orf211 0.76 13.7 0.6 4.22e-34 Menarche (age at onset); CRC cis rs5750830 0.546 rs4821891 chr22:39785381 C/T cg11247378 chr22:39784982 NA -0.5 -9.81 -0.48 4.22e-20 Intelligence (multi-trait analysis); CRC cis rs13108904 0.935 rs2293633 chr4:1291640 T/C cg15763984 chr4:1342303 KIAA1530 0.34 6.01 0.31 4.89e-9 Obesity-related traits; CRC cis rs9381040 0.610 rs2235678 chr6:41020510 G/T cg03644281 chr6:41068752 NFYA;LOC221442 -0.44 -6.37 -0.33 6.31e-10 Alzheimer's disease (late onset); CRC trans rs57221529 0.766 rs72706610 chr5:561111 G/A cg11887960 chr12:57824829 NA 0.58 6.42 0.33 4.65e-10 Lung disease severity in cystic fibrosis; CRC cis rs56283067 0.847 rs11962872 chr6:44690740 T/G cg18551225 chr6:44695536 NA -0.41 -5.96 -0.31 6.36e-9 Total body bone mineral density; CRC cis rs929354 0.651 rs6951298 chr7:156949149 T/C cg05182265 chr7:156933206 UBE3C -0.76 -14.38 -0.62 1.04e-36 Body mass index; CRC trans rs2797160 1.000 rs4897152 chr6:126002400 A/G cg05039488 chr6:79577232 IRAK1BP1 -0.5 -7.39 -0.38 1.2e-12 Endometrial cancer; CRC cis rs4662945 0.688 rs62174140 chr2:130202893 C/T cg05962382 chr2:130345044 NA -0.33 -5.61 -0.3 4.24e-8 Response to cytidine analogues (gemcitabine); CRC trans rs17807624 1.000 rs17807624 chr8:11463015 A/G cg16141378 chr3:129829833 LOC729375 0.45 6.45 0.34 4.07e-10 Systemic lupus erythematosus; CRC cis rs34375054 0.573 rs12831151 chr12:125656263 C/T cg06287003 chr12:125626642 AACS -0.56 -6.66 -0.34 1.14e-10 Post bronchodilator FEV1/FVC ratio; CRC cis rs2404602 0.692 rs1838048 chr15:76931679 A/G cg03037974 chr15:76606532 NA 0.72 12.72 0.57 1.97e-30 Blood metabolite levels; CRC cis rs736801 0.780 rs12521868 chr5:131784393 A/C cg00255919 chr5:131827918 IRF1 0.35 6.09 0.32 3.24e-9 Breast cancer;Mosquito bite size; CRC trans rs61931739 0.500 rs11053203 chr12:34456593 C/T cg26384229 chr12:38710491 ALG10B 0.66 8.7 0.43 1.62e-16 Morning vs. evening chronotype; CRC cis rs10486722 0.606 rs2108171 chr7:41776690 G/A cg22138096 chr7:41772439 LOC285954 0.43 5.65 0.3 3.53e-8 Pit-and-Fissure caries; CRC cis rs9814567 1.000 rs7432268 chr3:134242051 T/A cg06109529 chr3:134205091 CEP63;ANAPC13 -0.82 -12.4 -0.56 3.1e-29 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs10046574 0.831 rs111522774 chr7:135135327 C/A cg27474649 chr7:135195673 CNOT4 0.69 5.71 0.3 2.49e-8 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs3768617 0.677 rs12739316 chr1:183052080 G/A ch.1.3577855R chr1:183094577 LAMC1 0.65 9.87 0.48 2.78e-20 Fuchs's corneal dystrophy; CRC cis rs12887734 0.524 rs4906364 chr14:104214342 C/G cg08213375 chr14:104286397 PPP1R13B 0.51 8.64 0.43 2.49e-16 Schizophrenia;Autism spectrum disorder or schizophrenia; CRC cis rs2270875 1.000 rs2270875 chr8:132999936 A/G cg24184792 chr8:132919238 EFR3A -0.61 -5.9 -0.31 9.02e-9 Response to cholinesterase inhibitors in Alzheimer's disease; CRC cis rs9916302 0.904 rs612194 chr17:37442707 T/A cg07936489 chr17:37558343 FBXL20 0.81 12.55 0.57 8.49e-30 Glomerular filtration rate (creatinine); CRC cis rs951366 0.617 rs9438393 chr1:205782718 A/G cg24739457 chr1:205821442 NA 0.44 6.35 0.33 7.31e-10 Menarche (age at onset); CRC cis rs4713118 0.616 rs9348789 chr6:28025486 C/T cg23161317 chr6:28129485 ZNF389 0.44 5.71 0.3 2.49e-8 Parkinson's disease; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg00345343 chr16:89422185 ANKRD11 -0.36 -5.97 -0.31 5.99e-9 Liver disease severity in Alagille syndrome; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg01069170 chr19:44031473 ETHE1 0.43 6.8 0.35 4.96e-11 Liver disease severity in Alagille syndrome; CRC cis rs1728785 0.591 rs10775305 chr16:68656460 A/G cg02972257 chr16:68554789 NA -0.53 -6.62 -0.34 1.48e-10 Ulcerative colitis; CRC cis rs4969178 0.965 rs938351 chr17:76399404 C/T cg20026190 chr17:76395443 PGS1 0.38 5.71 0.3 2.5e-8 HDL cholesterol levels; CRC cis rs12760731 0.623 rs2862378 chr1:178296566 A/G cg00404053 chr1:178313656 RASAL2 0.71 9.05 0.45 1.31e-17 Obesity-related traits; CRC cis rs1005277 0.540 rs116205409 chr10:38478970 G/A cg25517755 chr10:38738941 LOC399744 -0.44 -6.44 -0.33 4.31e-10 Extrinsic epigenetic age acceleration; CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg05477027 chr19:46295590 DMWD -0.51 -6.13 -0.32 2.48e-9 Diisocyanate-induced asthma; CRC cis rs6921919 0.789 rs6456814 chr6:28305812 C/A cg15845792 chr6:28175446 NA 0.46 5.87 0.31 1.04e-8 Autism spectrum disorder or schizophrenia; CRC cis rs7589728 0.563 rs78168096 chr2:88473575 G/A cg04511125 chr2:88470314 THNSL2 0.78 8.02 0.4 1.92e-14 Plasma clusterin levels; CRC cis rs7647973 0.925 rs4955423 chr3:49220448 G/A cg07636037 chr3:49044803 WDR6 0.64 7.91 0.4 4.06e-14 Menarche (age at onset); CRC cis rs9311474 0.508 rs6805156 chr3:52609362 T/C cg15147215 chr3:52552868 STAB1 -0.63 -10.98 -0.52 4.02e-24 Electroencephalogram traits; CRC cis rs79349575 0.783 rs4793998 chr17:47019899 C/T cg00947319 chr17:47005597 UBE2Z -0.34 -5.89 -0.31 9.32e-9 Type 2 diabetes; CRC trans rs7746199 0.736 rs17693963 chr6:27710165 A/C cg06606381 chr12:133084897 FBRSL1 -1.12 -7.76 -0.39 1.06e-13 Gait speed in old age;Autism spectrum disorder or schizophrenia; CRC cis rs10905065 0.965 rs10737019 chr10:5783733 G/A cg11519256 chr10:5708881 ASB13 0.53 7.83 0.4 6.73e-14 Menopause (age at onset); CRC cis rs3749237 0.595 rs4855877 chr3:49448527 T/C cg07636037 chr3:49044803 WDR6 0.55 8.1 0.41 1.08e-14 Resting heart rate; CRC cis rs4561483 0.832 rs171656 chr16:11953167 C/T cg08843971 chr16:11963173 GSPT1 -0.62 -9.76 -0.47 6.12e-20 Testicular germ cell tumor; CRC trans rs4927850 0.881 rs7624638 chr3:195748729 C/T cg16724585 chr3:197361211 NA -0.48 -7.1 -0.36 7.8e-12 Pancreatic cancer; CRC trans rs6550704 0.687 rs9865314 chr3:22634337 A/G cg11206763 chr12:56521692 ESYT1 -0.44 -6.47 -0.34 3.57e-10 Daytime sleep phenotypes; CRC cis rs2295359 0.892 rs6688383 chr1:67655954 C/T cg03340356 chr1:67600835 NA -0.28 -6.37 -0.33 6.22e-10 Psoriasis; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg10723012 chr17:79995434 DCXR 0.45 6.25 0.33 1.3e-9 Anxiety disorder; CRC cis rs2735413 0.881 rs12921945 chr16:78080133 G/T cg04733911 chr16:78082701 NA -0.45 -7.44 -0.38 8.84e-13 Systolic blood pressure (alcohol consumption interaction); CRC cis rs7914558 0.966 rs2297786 chr10:104679978 C/T cg15744005 chr10:104629667 AS3MT -0.35 -7.51 -0.38 5.75e-13 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs12530845 0.524 rs7795267 chr7:135308455 C/G cg23117316 chr7:135346802 PL-5283 -0.41 -5.7 -0.3 2.64e-8 Red blood cell traits; CRC cis rs4648845 0.777 rs2477686 chr1:2392648 C/G cg02275930 chr1:2372054 NA -0.58 -9.94 -0.48 1.56e-20 Schizophrenia; CRC cis rs11608355 0.545 rs11613023 chr12:109898047 T/C cg05360138 chr12:110035743 NA 0.77 8.7 0.43 1.65e-16 Neuroticism; CRC cis rs2579500 0.885 rs2579501 chr2:97199251 G/A cg23100626 chr2:96804247 ASTL 0.24 5.74 0.3 2.1e-8 Eosinophil counts;Eosinophil percentage of white cells; CRC trans rs10982213 0.830 rs2274163 chr9:117188714 C/T cg10190698 chr14:50154770 POLE2 0.39 6.0 0.31 5.28e-9 Interleukin-6 levels; CRC cis rs951366 0.903 rs823114 chr1:205719532 G/A cg14893161 chr1:205819251 PM20D1 0.48 7.29 0.37 2.28e-12 Menarche (age at onset); CRC cis rs853679 0.517 rs9380060 chr6:28132603 G/A cg03623178 chr6:28175578 NA 0.98 12.66 0.57 3.31e-30 Depression; CRC trans rs6951245 0.744 rs10265758 chr7:1172518 C/T cg13565492 chr6:43139072 SRF -0.71 -8.09 -0.41 1.15e-14 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs4604732 0.631 rs76761880 chr1:247626377 T/A cg12758973 chr1:247694275 LOC148824;OR2C3 0.42 6.14 0.32 2.32e-9 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CRC cis rs875971 0.862 rs10263690 chr7:65766453 G/C cg11764359 chr7:65958608 NA -0.59 -8.72 -0.43 1.38e-16 Aortic root size; CRC cis rs4917385 1 rs4917385 chr10:105003721 T/G cg04362960 chr10:104952993 NT5C2 0.5 6.53 0.34 2.51e-10 Systemic lupus erythematosus; CRC cis rs898097 0.585 rs9893200 chr17:80893028 A/C cg19046167 chr17:80928561 B3GNTL1 0.45 7.69 0.39 1.7e-13 Breast cancer; CRC cis rs11155671 0.530 rs9322228 chr6:150209309 C/G cg13206674 chr6:150067644 NUP43 0.49 7.03 0.36 1.22e-11 Testicular germ cell tumor; CRC cis rs7677751 0.806 rs61320297 chr4:55088175 G/A cg13615338 chr4:55094005 PDGFRA 0.42 6.01 0.31 4.81e-9 Corneal astigmatism; CRC cis rs7119 0.689 rs12916833 chr15:77819778 G/A cg10437265 chr15:77819839 NA 0.69 12.57 0.57 7.62e-30 Type 2 diabetes; CRC cis rs992157 0.560 rs4674274 chr2:219089131 A/T cg04880052 chr2:219191631 PNKD -0.42 -6.65 -0.34 1.25e-10 Colorectal cancer; CRC cis rs2933343 0.729 rs6790091 chr3:128608751 G/C cg11901034 chr3:128598214 ACAD9 -0.55 -7.76 -0.39 1.06e-13 IgG glycosylation; CRC cis rs10256972 0.732 rs12701856 chr7:1107707 C/T cg16145915 chr7:1198662 ZFAND2A -0.31 -5.79 -0.3 1.61e-8 Longevity;Endometriosis; CRC cis rs7044106 0.500 rs56725168 chr9:123492576 T/G cg14255062 chr9:123606675 PSMD5;LOC253039 0.5 7.55 0.38 4.36e-13 Hip circumference adjusted for BMI; CRC cis rs11764590 0.756 rs17132130 chr7:2108036 G/C cg14004847 chr7:1930337 MAD1L1 -0.46 -5.91 -0.31 8.45e-9 Neuroticism; CRC cis rs798554 0.757 rs1713919 chr7:2864706 C/A cg19717773 chr7:2847554 GNA12 -0.49 -7.07 -0.36 9.29e-12 Height; CRC cis rs1448094 0.621 rs10863090 chr12:86282211 C/T cg19622623 chr12:86230825 RASSF9 -0.39 -6.19 -0.32 1.77e-9 Major depressive disorder; CRC trans rs9747201 0.862 rs57596657 chr17:80147978 C/T cg07393940 chr7:158741817 NA 0.51 7.38 0.38 1.34e-12 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs1577917 0.666 rs6454471 chr6:86214456 T/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A 0.67 8.79 0.44 8.52e-17 Response to antipsychotic treatment; CRC cis rs4731207 0.698 rs10156168 chr7:124494410 G/T cg23710748 chr7:124431027 NA -0.38 -6.08 -0.32 3.42e-9 Cutaneous malignant melanoma; CRC cis rs832187 0.813 rs704369 chr3:63868271 G/A cg16258503 chr3:63850278 ATXN7;THOC7 0.4 5.72 0.3 2.41e-8 Schizophrenia; CRC cis rs3749237 1.000 rs11130214 chr3:49735746 C/G cg03060546 chr3:49711283 APEH -0.44 -6.72 -0.35 8.23e-11 Resting heart rate; CRC trans rs7937682 0.855 rs527078 chr11:111479713 T/C cg18187862 chr3:45730750 SACM1L 0.46 6.7 0.35 9.15e-11 Primary sclerosing cholangitis; CRC cis rs7209700 0.708 rs15908 chr17:45368337 A/C cg08085267 chr17:45401833 C17orf57 0.48 7.03 0.36 1.16e-11 IgG glycosylation; CRC cis rs6772849 0.930 rs9873888 chr3:128360987 G/A cg08795948 chr3:128337044 NA 0.36 6.28 0.33 1.04e-9 Monocyte percentage of white cells;Monocyte count; CRC cis rs11098499 0.954 rs13133522 chr4:120324424 A/T cg09307838 chr4:120376055 NA 0.72 11.14 0.52 1.1e-24 Corneal astigmatism; CRC trans rs7647973 0.626 rs1491985 chr3:49739507 G/C cg21665057 chr3:196295764 WDR53;FBXO45 -0.63 -7.12 -0.37 6.62e-12 Menarche (age at onset); CRC cis rs270601 0.661 rs10036208 chr5:131571323 T/C cg18301423 chr5:131593218 PDLIM4 0.47 8.07 0.41 1.3e-14 Acylcarnitine levels; CRC cis rs6785206 0.772 rs2811493 chr3:128357299 C/G cg16766828 chr3:128327626 NA -0.51 -5.67 -0.3 3.18e-8 Lymphocyte percentage of white cells; CRC cis rs72634258 0.699 rs12128234 chr1:8170219 T/C cg00042356 chr1:8021962 PARK7 -0.56 -6.32 -0.33 8.27e-10 Inflammatory bowel disease; CRC cis rs875971 0.830 rs6950137 chr7:65976610 G/A cg18252515 chr7:66147081 NA -0.42 -6.22 -0.32 1.53e-9 Aortic root size; CRC cis rs4234798 1.000 rs4234798 chr4:7219933 G/T cg18431297 chr4:7219810 SORCS2 -0.64 -11.62 -0.54 2.25e-26 Insulin-like growth factors; CRC cis rs9469890 0.604 rs77587944 chr6:34503644 T/G cg17674042 chr6:34482479 PACSIN1 -0.66 -7.76 -0.39 1.1e-13 Pubertal anthropometrics;Coronary artery disease; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg01084379 chr5:179160712 MAML1 -0.41 -5.96 -0.31 6.51e-9 Myopia (pathological); CRC cis rs853679 1.000 rs13200462 chr6:28218199 A/C cg06470822 chr6:28175283 NA 0.71 6.67 0.34 1.11e-10 Depression; CRC cis rs832540 0.931 rs832535 chr5:56213334 C/T cg12311346 chr5:56204834 C5orf35 -0.51 -7.97 -0.4 2.58e-14 Coronary artery disease; CRC cis rs9894429 0.646 rs7405937 chr17:79597811 G/A cg09655341 chr17:79618100 PDE6G -0.36 -6.24 -0.33 1.31e-9 Eye color traits; CRC cis rs10504229 0.683 rs7835498 chr8:58129780 A/C cg21724239 chr8:58056113 NA 0.49 6.81 0.35 4.75e-11 Developmental language disorder (linguistic errors); CRC cis rs733592 0.524 rs10875744 chr12:48498440 G/C cg24011408 chr12:48396354 COL2A1 0.45 6.68 0.35 1.03e-10 Plateletcrit; CRC cis rs57994353 0.793 rs12552167 chr9:139322927 C/T cg14119001 chr9:139324193 INPP5E -0.53 -7.55 -0.38 4.32e-13 Eosinophil counts;Cutaneous squamous cell carcinoma; CRC cis rs796364 0.760 rs55906940 chr2:201049386 A/G cg25936922 chr2:200820526 C2orf60;C2orf47 -0.65 -5.95 -0.31 6.82e-9 Schizophrenia; CRC trans rs17723576 0.649 rs6122799 chr20:48238612 A/G cg18830952 chr12:132606769 EP400NL 0.52 6.12 0.32 2.7e-9 Urate levels in obese individuals; CRC cis rs11971779 0.688 rs1862880 chr7:139020100 T/C cg07862535 chr7:139043722 LUC7L2 0.82 10.35 0.5 6.51e-22 Diisocyanate-induced asthma; CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg08732623 chr10:127408269 C10orf137 0.4 6.51 0.34 2.87e-10 Obesity-related traits; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg06666157 chr19:4791552 FEM1A 0.52 6.82 0.35 4.48e-11 Thyroid stimulating hormone; CRC cis rs10479542 0.896 rs4701131 chr5:178982446 A/G cg00080972 chr5:178986291 RUFY1 0.48 9.72 0.47 8.5e-20 Lung cancer; CRC cis rs8180040 0.966 rs9683033 chr3:47489820 C/T cg27129171 chr3:47204927 SETD2 0.52 8.15 0.41 7.57e-15 Colorectal cancer; CRC trans rs10982213 0.830 rs2274163 chr9:117188714 C/T cg26859392 chr3:10143019 FANCD2;C3orf24 0.39 6.11 0.32 2.88e-9 Interleukin-6 levels; CRC cis rs10089 1.000 rs6595806 chr5:127499764 A/T cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.72 10.01 0.48 9.03e-21 Ileal carcinoids; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg17745251 chr10:21806139 C10orf140 0.41 5.98 0.31 5.68e-9 Liver disease severity in Alagille syndrome; CRC cis rs10256972 0.552 rs2960837 chr7:1203957 A/G cg23978390 chr7:1156363 C7orf50 0.51 7.16 0.37 5.33e-12 Longevity;Endometriosis; CRC cis rs7772486 0.686 rs1292337 chr6:145967807 A/G cg23711669 chr6:146136114 FBXO30 -0.64 -10.5 -0.5 1.94e-22 Lobe attachment (rater-scored or self-reported); CRC trans rs6550704 0.687 rs9865314 chr3:22634337 A/G cg15450734 chr14:103541957 NA -0.42 -6.31 -0.33 9.21e-10 Daytime sleep phenotypes; CRC cis rs4625783 0.583 rs11077974 chr17:80095193 A/G cg19223190 chr17:80058835 NA 0.4 6.36 0.33 6.88e-10 Blood metabolite levels; CRC cis rs853679 0.517 rs16893666 chr6:28054707 C/T cg03623178 chr6:28175578 NA -0.94 -12.29 -0.56 7.72e-29 Depression; CRC cis rs2075371 0.933 rs2544201 chr7:133963561 C/G cg20476274 chr7:133979776 SLC35B4 0.78 14.12 0.61 9.93e-36 Mean platelet volume; CRC cis rs17767392 0.958 rs34454371 chr14:71881502 C/G cg13720639 chr14:72061746 SIPA1L1 -0.55 -6.95 -0.36 1.92e-11 Mitral valve prolapse; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg07280629 chr16:30583784 ZNF688 0.45 6.07 0.32 3.5e-9 Anxiety disorder; CRC cis rs6951245 1.000 rs77305932 chr7:1100861 T/A cg18402987 chr7:1209562 NA 0.67 7.17 0.37 5.02e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs7827545 1.000 rs6578238 chr8:135569490 A/C cg13086574 chr8:135490821 ZFAT -0.37 -6.51 -0.34 2.75e-10 Hypertension (SNP x SNP interaction); CRC cis rs34779708 0.733 rs4444023 chr10:35548354 G/A cg03585969 chr10:35415529 CREM 0.52 6.79 0.35 5.37e-11 Inflammatory bowel disease;Crohn's disease; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg01426831 chr19:12098817 NA 0.48 6.09 0.32 3.08e-9 Thyroid stimulating hormone; CRC cis rs2153535 0.580 rs2327053 chr6:8443127 A/G cg07606381 chr6:8435919 SLC35B3 0.68 10.88 0.51 9.21e-24 Motion sickness; CRC cis rs4073416 0.542 rs11158603 chr14:66072040 C/T cg03016385 chr14:66212404 NA -0.47 -6.35 -0.33 7.06e-10 N-glycan levels; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg04309227 chr1:26561027 CCDC21 0.44 6.33 0.33 7.99e-10 Response to antipsychotic treatment; CRC cis rs860295 0.702 rs11264380 chr1:155520144 T/C cg02153340 chr1:155202674 NA -0.5 -6.29 -0.33 9.99e-10 Body mass index; CRC cis rs1448094 0.512 rs1900701 chr12:86236231 T/C cg02569458 chr12:86230093 RASSF9 0.42 7.18 0.37 4.78e-12 Major depressive disorder; CRC cis rs6502050 0.835 rs8071737 chr17:80117537 T/C cg25804541 chr17:80189381 SLC16A3 -0.3 -5.88 -0.31 9.84e-9 Life satisfaction; CRC cis rs17666538 0.585 rs1669733 chr8:606696 C/T cg10396713 chr8:602097 NA -0.59 -6.15 -0.32 2.2e-9 IgG glycosylation; CRC cis rs10504229 0.610 rs6999661 chr8:58127391 C/G cg21724239 chr8:58056113 NA 0.49 6.81 0.35 4.75e-11 Developmental language disorder (linguistic errors); CRC cis rs372883 0.530 rs2832305 chr21:30752964 G/A cg24692254 chr21:30365293 RNF160 0.52 8.02 0.4 1.93e-14 Pancreatic cancer; CRC trans rs7615952 0.512 rs34651730 chr3:125358640 T/C cg17147758 chr8:6949321 NA -0.52 -7.2 -0.37 4.24e-12 Blood pressure (smoking interaction); CRC cis rs4332037 0.713 rs56093134 chr7:1973970 C/T cg25834613 chr7:1915315 MAD1L1 -0.45 -6.42 -0.33 4.64e-10 Bipolar disorder; CRC cis rs6952808 0.771 rs10244946 chr7:1921068 A/G cg22963979 chr7:1858916 MAD1L1 0.48 7.58 0.39 3.6e-13 Bipolar disorder and schizophrenia; CRC cis rs9311474 0.652 rs411457 chr3:52228150 A/T cg15147215 chr3:52552868 STAB1 0.47 7.62 0.39 2.8e-13 Electroencephalogram traits; CRC trans rs11165623 0.602 rs4127309 chr1:97006892 T/C cg10631902 chr5:14652156 NA -0.39 -6.58 -0.34 1.89e-10 Hip circumference;Waist circumference; CRC cis rs5758511 0.773 rs1894714 chr22:42349134 T/G cg00645731 chr22:42541494 CYP2D7P1 -0.47 -7.0 -0.36 1.47e-11 Birth weight; CRC cis rs12701220 0.572 rs7792825 chr7:1006573 T/C cg02733842 chr7:1102375 C7orf50 -0.49 -6.29 -0.33 1.02e-9 Bronchopulmonary dysplasia; CRC cis rs904251 1.000 rs12212090 chr6:37431808 A/G cg01843034 chr6:37503916 NA -0.39 -7.12 -0.37 6.78e-12 Cognitive performance; CRC cis rs2749592 0.531 rs1208559 chr10:38221370 T/C cg00409905 chr10:38381863 ZNF37A 0.56 8.75 0.43 1.15e-16 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs7937682 0.558 rs7113067 chr11:111692182 G/A cg09085632 chr11:111637200 PPP2R1B 0.95 15.1 0.64 1.7e-39 Primary sclerosing cholangitis; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg11032208 chr5:95997736 CAST 0.41 6.21 0.32 1.59e-9 Liver disease severity in Alagille syndrome; CRC cis rs2976388 0.609 rs2572909 chr8:143806464 C/G cg12516270 chr8:143859308 LYNX1 0.43 7.57 0.39 3.83e-13 Urinary tract infection frequency; CRC cis rs4970988 0.556 rs6681426 chr1:150586971 G/A cg10589385 chr1:150898437 SETDB1 -0.33 -6.88 -0.35 3.09e-11 Urate levels; CRC cis rs7772486 0.790 rs2265919 chr6:146221753 A/G cg13319975 chr6:146136371 FBXO30 -0.41 -6.16 -0.32 2.18e-9 Lobe attachment (rater-scored or self-reported); CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg09414045 chr1:110162465 AMPD2 -0.42 -6.28 -0.33 1.1e-9 Myopia (pathological); CRC cis rs1707322 0.964 rs785496 chr1:46588006 T/C cg06784218 chr1:46089804 CCDC17 -0.61 -10.54 -0.5 1.37e-22 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC trans rs12663356 0.528 rs9350359 chr6:21462624 C/T cg11407215 chr2:106810146 UXS1 0.42 6.27 0.33 1.15e-9 Crohn's disease; CRC cis rs9816226 1.000 rs73052033 chr3:185828465 T/C cg00760338 chr3:185826511 ETV5 -0.78 -7.78 -0.39 9.41e-14 Obesity;Body mass index; CRC trans rs11252926 0.624 rs7085214 chr10:468133 A/G cg00953403 chr17:74099816 EXOC7 0.5 7.63 0.39 2.48e-13 Psychosis in Alzheimer's disease; CRC cis rs9491140 0.539 rs12210199 chr6:124684045 C/A cg05308643 chr6:124982296 NKAIN2 0.5 6.9 0.36 2.63e-11 Neuroticism; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg26085966 chr14:64319812 SYNE2 -0.48 -7.71 -0.39 1.51e-13 Myopia (pathological); CRC cis rs10876993 0.928 rs2640631 chr12:58067532 A/T cg15848620 chr12:58087721 OS9 -0.58 -8.19 -0.41 5.85e-15 Celiac disease or Rheumatoid arthritis; CRC trans rs4942242 0.763 rs7326281 chr13:44233186 G/A cg19169023 chr15:41853346 TYRO3 -0.65 -9.81 -0.48 4.34e-20 Response to tocilizumab in rheumatoid arthritis; CRC cis rs12451471 0.637 rs12452616 chr17:78090081 A/G cg24585782 chr17:78113791 EIF4A3 0.47 6.59 0.34 1.71e-10 Plateletcrit;Mean corpuscular hemoglobin concentration; CRC trans rs1728785 0.786 rs1728770 chr16:68564124 G/C cg04657470 chr2:198365150 HSPE1;HSPD1 0.76 8.68 0.43 1.88e-16 Ulcerative colitis; CRC cis rs4727027 0.933 rs34578816 chr7:148847606 G/A cg12479418 chr7:148823350 ZNF425;ZNF398 0.44 5.98 0.31 5.76e-9 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC cis rs8180040 0.966 rs2291298 chr3:47555142 C/A cg02527881 chr3:46936655 PTH1R -0.39 -7.4 -0.38 1.14e-12 Colorectal cancer; CRC trans rs1005277 0.579 rs1740742 chr10:38518860 C/T cg27523141 chr10:43048294 ZNF37B 0.47 6.9 0.36 2.69e-11 Extrinsic epigenetic age acceleration; CRC cis rs11098499 0.789 rs12498994 chr4:120250818 A/C cg09307838 chr4:120376055 NA 0.61 9.59 0.47 2.22e-19 Corneal astigmatism; CRC cis rs9894429 0.671 rs6565616 chr17:79612161 C/T cg09655341 chr17:79618100 PDE6G -0.34 -5.84 -0.31 1.26e-8 Eye color traits; CRC cis rs763121 0.853 rs138712 chr22:39141600 C/T cg06022373 chr22:39101656 GTPBP1 0.81 11.81 0.55 4.54e-27 Menopause (age at onset); CRC cis rs9394438 0.628 rs804843 chr6:37545923 A/G cg00985040 chr6:37553208 NA -0.35 -6.03 -0.32 4.4e-9 IgG glycosylation; CRC cis rs2180341 0.521 rs12189967 chr6:127718058 G/A cg27446573 chr6:127587934 RNF146 0.48 6.97 0.36 1.77e-11 Breast cancer; CRC cis rs1559088 0.744 rs12972060 chr19:33537096 C/T cg27124370 chr19:33622961 WDR88 -0.42 -5.88 -0.31 1e-8 Bone ultrasound measurement (broadband ultrasound attenuation); CRC cis rs155076 0.625 rs4769159 chr13:21881978 A/C cg23743428 chr13:21893420 NA -0.39 -5.91 -0.31 8.78e-9 White matter hyperintensity burden; CRC cis rs713477 1.000 rs7142204 chr14:55908436 G/T cg13175173 chr14:55914753 NA 0.52 9.99 0.48 1.07e-20 Pediatric bone mineral content (femoral neck); CRC cis rs514406 0.861 rs12038438 chr1:53230581 A/T cg27535305 chr1:53392650 SCP2 0.39 7.02 0.36 1.29e-11 Monocyte count; CRC cis rs6912958 0.525 rs59322 chr6:88020521 C/A cg04972856 chr6:88032051 C6orf162;GJB7 0.31 5.72 0.3 2.33e-8 Monocyte percentage of white cells; CRC trans rs7267979 1.000 rs1888997 chr20:25298988 G/A cg17903999 chr18:56338584 MALT1 0.44 7.16 0.37 5.3e-12 Liver enzyme levels (alkaline phosphatase); CRC cis rs7829975 0.517 rs12542733 chr8:8824858 G/T cg06636001 chr8:8085503 FLJ10661 -0.48 -7.63 -0.39 2.54e-13 Mood instability; CRC cis rs9463078 0.605 rs9472411 chr6:44943183 T/C cg25276700 chr6:44698697 NA 0.25 6.22 0.32 1.5e-9 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; CRC trans rs4843747 0.641 rs11117353 chr16:88090895 A/G cg26811252 chr16:29126840 RRN3P2 0.72 9.89 0.48 2.28e-20 Menopause (age at onset); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg11915997 chr19:7745524 TRAPPC5 0.43 6.21 0.32 1.61e-9 Intelligence (multi-trait analysis); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg14546261 chr12:7052696 C12orf57 0.46 6.54 0.34 2.32e-10 Response to antipsychotic treatment; CRC trans rs2243480 1.000 rs10807701 chr7:65724686 C/A cg10756647 chr7:56101905 PSPH -0.78 -8.04 -0.41 1.65e-14 Diabetic kidney disease; CRC cis rs875971 0.651 rs313829 chr7:65552497 A/G cg18876405 chr7:65276391 NA -0.42 -6.12 -0.32 2.64e-9 Aortic root size; CRC cis rs992157 0.560 rs12992937 chr2:219087072 A/T cg00012203 chr2:219082015 ARPC2 -0.54 -8.52 -0.43 5.77e-16 Colorectal cancer; CRC cis rs6456156 0.586 rs9457261 chr6:167467679 A/G cg07741184 chr6:167504864 NA 0.38 6.81 0.35 4.72e-11 Primary biliary cholangitis; CRC cis rs1218582 0.744 rs6674853 chr1:154892753 G/C cg06221963 chr1:154839813 KCNN3 -0.79 -14.76 -0.63 3.31e-38 Prostate cancer; CRC trans rs1908814 0.516 rs4840597 chr8:11796068 A/C cg06636001 chr8:8085503 FLJ10661 0.48 7.06 0.36 1.02e-11 Neuroticism; CRC cis rs6502050 0.835 rs8065981 chr17:80091393 G/T cg11859384 chr17:80120422 CCDC57 -0.38 -5.98 -0.31 5.84e-9 Life satisfaction; CRC cis rs2384207 0.818 rs7955036 chr12:113715251 T/G cg22376712 chr12:113623594 C12orf52;DDX54 0.5 6.21 0.32 1.63e-9 Response to fenofibrate (adiponectin levels); CRC cis rs7666738 0.606 rs28625338 chr4:99076996 A/G cg05340658 chr4:99064831 C4orf37 0.49 7.16 0.37 5.35e-12 Colonoscopy-negative controls vs population controls; CRC cis rs5167 0.504 rs7257476 chr19:45453165 C/T cg13119609 chr19:45449297 APOC2 0.32 6.02 0.32 4.62e-9 Blood protein levels; CRC cis rs6076065 0.644 rs1056394 chr20:23337422 G/A cg11657817 chr20:23433608 CST11 0.47 7.08 0.36 8.79e-12 Facial morphology (factor 15, philtrum width); CRC cis rs28386778 0.897 rs896064 chr17:61860932 C/T cg06601766 chr17:61851465 DDX42;CCDC47 0.46 6.22 0.32 1.51e-9 Prudent dietary pattern; CRC cis rs1355223 0.583 rs2915178 chr11:34878051 C/T cg24088639 chr11:34937564 PDHX;APIP -0.59 -8.62 -0.43 2.92e-16 Systemic lupus erythematosus and Systemic sclerosis; CRC cis rs11971779 0.648 rs6967836 chr7:139079944 C/G cg07862535 chr7:139043722 LUC7L2 0.56 7.24 0.37 3.2e-12 Diisocyanate-induced asthma; CRC cis rs8060686 0.623 rs56303487 chr16:68029739 C/T cg05110241 chr16:68378359 PRMT7 -0.49 -5.66 -0.3 3.28e-8 HDL cholesterol;Metabolic syndrome; CRC cis rs6500395 1.000 rs6500398 chr16:48650332 C/T cg04672837 chr16:48644449 N4BP1 0.44 6.47 0.34 3.62e-10 Response to tocilizumab in rheumatoid arthritis; CRC cis rs1005224 0.926 rs12892551 chr14:76159902 C/T cg04684003 chr14:76127793 TTLL5;C14orf1 -0.43 -6.05 -0.32 3.93e-9 Large artery stroke; CRC cis rs208520 0.837 rs208467 chr6:66914837 T/C cg07460842 chr6:66804631 NA -0.91 -12.19 -0.56 1.77e-28 Exhaled nitric oxide output; CRC cis rs483180 0.531 rs541503 chr1:120208297 A/G cg19096424 chr1:120255104 PHGDH -0.44 -6.37 -0.33 6.55e-10 Macular telangiectasia type 2; CRC cis rs72781680 0.948 rs72796385 chr2:24170360 T/A cg08917208 chr2:24149416 ATAD2B 0.91 9.24 0.45 3.06e-18 Lymphocyte counts; CRC cis rs13118159 0.550 rs2878607 chr4:1353310 G/C cg02018176 chr4:1364513 KIAA1530 0.71 12.31 0.56 6.75e-29 Longevity; CRC cis rs6540559 0.740 rs2064163 chr1:210048819 G/T cg21951975 chr1:209979733 IRF6 0.4 5.78 0.3 1.71e-8 Cleft lip with or without cleft palate; CRC cis rs1401999 0.898 rs4148561 chr3:183726379 A/G cg20387954 chr3:183756860 HTR3D 0.46 7.81 0.4 7.91e-14 Anterior chamber depth; CRC cis rs4713118 0.662 rs13218430 chr6:28029837 T/C cg21251018 chr6:28226885 NKAPL 0.46 6.53 0.34 2.56e-10 Parkinson's disease; CRC cis rs728616 0.867 rs1983775 chr10:81663575 G/A cg11900509 chr10:81946545 ANXA11 -0.62 -6.31 -0.33 8.96e-10 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs12541635 0.677 rs1496180 chr8:106973877 T/G cg10147462 chr8:107024639 NA 0.55 9.48 0.46 5.19e-19 Age of smoking initiation; CRC cis rs10911232 0.524 rs4487994 chr1:182982173 T/A ch.1.3577855R chr1:183094577 LAMC1 0.87 15.34 0.65 1.91e-40 Hypertriglyceridemia; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg16265078 chr11:85955426 EED 0.43 6.51 0.34 2.86e-10 Intelligence (multi-trait analysis); CRC trans rs1005277 0.579 rs9418322 chr10:38377296 G/T cg11292332 chr7:45801988 SEPT13 -0.35 -6.22 -0.32 1.52e-9 Extrinsic epigenetic age acceleration; CRC cis rs4423214 0.840 rs1790340 chr11:71182589 T/C cg13043300 chr11:71146211 DHCR7 -0.46 -6.21 -0.32 1.64e-9 Vitamin D levels; CRC cis rs4319547 0.915 rs10773208 chr12:122970156 T/C cg05707623 chr12:122985044 ZCCHC8 -0.81 -10.21 -0.49 1.9e-21 Body mass index; CRC cis rs9648716 1.000 rs10232557 chr7:140452363 C/G cg10747023 chr7:140774559 NA 0.45 5.8 0.3 1.52e-8 Type 2 diabetes; CRC cis rs875971 0.545 rs73142233 chr7:65686280 T/A cg11764359 chr7:65958608 NA 0.45 5.67 0.3 3.1e-8 Aortic root size; CRC cis rs3087591 1.000 rs12939853 chr17:29455021 G/A cg24425628 chr17:29625626 OMG;NF1 0.87 16.65 0.68 1.45e-45 Hip circumference; CRC cis rs2262909 0.962 rs55728714 chr19:22262899 A/G cg11619707 chr19:22235551 ZNF257 0.29 5.65 0.3 3.51e-8 Chagas cardiomyopathy in Tripanosoma cruzi seropositivity; CRC cis rs2836974 0.545 rs8128901 chr21:40710419 G/A cg17971929 chr21:40555470 PSMG1 0.51 7.14 0.37 6.09e-12 Cognitive function; CRC cis rs7703744 0.634 rs6884061 chr5:118683431 C/T cg02283238 chr5:118691126 TNFAIP8 0.48 6.67 0.35 1.06e-10 Lobe attachment (rater-scored or self-reported); CRC cis rs7224685 0.501 rs781839 chr17:3961489 C/T cg05562828 chr17:3906858 NA 0.65 11.87 0.55 2.78e-27 Type 2 diabetes; CRC cis rs317689 0.690 rs547827 chr12:69669703 G/A cg20891283 chr12:69753455 YEATS4 0.45 5.8 0.3 1.53e-8 Response to diuretic therapy; CRC cis rs28386778 0.897 rs2584639 chr17:61863732 C/T cg06601766 chr17:61851465 DDX42;CCDC47 0.44 6.04 0.32 4.16e-9 Prudent dietary pattern; CRC cis rs13315871 1.000 rs13078787 chr3:58430487 C/T cg20936604 chr3:58311152 NA -0.72 -7.17 -0.37 4.91e-12 Cholesterol, total; CRC cis rs904251 1.000 rs904251 chr6:37451696 G/T cg25019722 chr6:37503610 NA -0.36 -6.46 -0.34 3.8e-10 Cognitive performance; CRC cis rs9914988 0.943 rs11656256 chr17:27153553 G/A cg12682573 chr17:27188876 MIR451;MIR144 0.57 7.99 0.4 2.37e-14 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs7666738 0.791 rs1426661 chr4:98874303 C/G cg17366294 chr4:99064904 C4orf37 0.41 6.67 0.35 1.08e-10 Colonoscopy-negative controls vs population controls; CRC trans rs561341 0.739 rs1978116 chr17:30220978 A/C cg27661571 chr11:113659931 NA -0.47 -6.05 -0.32 3.92e-9 Hip circumference adjusted for BMI; CRC cis rs1572438 0.811 rs9379179 chr6:879853 A/C cg21062780 chr6:887772 NA 0.47 7.59 0.39 3.41e-13 Aging; CRC cis rs4654899 0.802 rs115818417 chr1:21200411 C/T cg02927042 chr1:21476669 EIF4G3 -0.46 -7.07 -0.36 9.41e-12 Superior frontal gyrus grey matter volume; CRC cis rs2549003 1.000 rs9282762 chr5:131822055 T/C cg00255919 chr5:131827918 IRF1 0.59 11.92 0.55 1.77e-27 Asthma (sex interaction); CRC cis rs9527 0.590 rs12415199 chr10:104895536 T/C cg15744005 chr10:104629667 AS3MT -0.31 -6.1 -0.32 3.03e-9 Arsenic metabolism; CRC cis rs4891159 1.000 rs4891159 chr18:74101941 A/G cg24786174 chr18:74118243 ZNF516 0.74 12.5 0.57 1.37e-29 Longevity; CRC cis rs832540 0.656 rs832573 chr5:56159578 T/C cg20203395 chr5:56204925 C5orf35 -0.42 -5.64 -0.3 3.57e-8 Coronary artery disease; CRC cis rs7677751 0.806 rs4864859 chr4:55090015 A/G cg17187183 chr4:55093834 PDGFRA 0.53 7.83 0.4 6.85e-14 Corneal astigmatism; CRC cis rs9322193 0.962 rs35443312 chr6:149991761 T/C cg07701084 chr6:150067640 NUP43 0.47 6.58 0.34 1.84e-10 Lung cancer; CRC cis rs10911232 0.507 rs4652762 chr1:182993960 T/C ch.1.3577855R chr1:183094577 LAMC1 0.86 15.15 0.64 1.1e-39 Hypertriglyceridemia; CRC cis rs4862750 0.832 rs9995958 chr4:187901764 G/A cg06074448 chr4:187884817 NA -0.6 -11.3 -0.53 2.95e-25 Lobe attachment (rater-scored or self-reported); CRC cis rs6840360 0.726 rs6816292 chr4:152730543 C/T cg09659197 chr4:152720779 NA -0.42 -8.96 -0.44 2.51e-17 Intelligence (multi-trait analysis); CRC cis rs7607369 0.580 rs17573724 chr2:219652141 T/A cg02176678 chr2:219576539 TTLL4 -0.56 -9.01 -0.44 1.76e-17 Red blood cell count;Amyotrophic lateral sclerosis; CRC cis rs10479542 0.544 rs7706275 chr5:178990305 A/G cg09060608 chr5:178986726 RUFY1 0.48 7.27 0.37 2.65e-12 Lung cancer; CRC cis rs9527 0.615 rs4917991 chr10:104783833 T/C cg15744005 chr10:104629667 AS3MT -0.3 -5.96 -0.31 6.63e-9 Arsenic metabolism; CRC cis rs950169 1.000 rs34751999 chr15:84758419 T/C cg24253500 chr15:84953950 NA 0.38 6.44 0.33 4.32e-10 Schizophrenia; CRC cis rs3806843 0.705 rs2530230 chr5:140088131 G/A cg19875535 chr5:140030758 IK -0.62 -10.16 -0.49 2.92e-21 Depressive symptoms (multi-trait analysis); CRC cis rs10911390 0.744 rs11802633 chr1:183647877 G/A cg11505048 chr1:183622726 RGL1;APOBEC4 0.71 6.24 0.33 1.33e-9 Systemic lupus erythematosus; CRC cis rs7584330 0.554 rs6760890 chr2:238400645 G/A cg08992911 chr2:238395768 MLPH 0.59 6.01 0.31 4.81e-9 Prostate cancer; CRC cis rs10504229 0.773 rs1874373 chr8:58194423 T/C cg02725872 chr8:58115012 NA -0.47 -8.48 -0.42 7.81e-16 Developmental language disorder (linguistic errors); CRC cis rs7727544 0.716 rs2089855 chr5:131573529 A/G cg12564285 chr5:131593104 PDLIM4 0.38 7.13 0.37 6.38e-12 Blood metabolite levels; CRC trans rs2727020 0.521 rs10839296 chr11:49537617 T/C cg03929089 chr4:120376271 NA 0.76 10.12 0.49 3.78e-21 Coronary artery disease; CRC cis rs7249142 0.562 rs2314035 chr19:19284920 T/C cg08207377 chr19:19281140 LOC729991-MEF2B;MEF2B -0.38 -6.14 -0.32 2.33e-9 IgG glycosylation; CRC cis rs282587 0.569 rs7982564 chr13:113398930 G/A cg04656015 chr13:113407548 ATP11A 0.61 7.69 0.39 1.68e-13 Glycated hemoglobin levels; CRC trans rs559356 0.519 rs554650 chr3:34840139 G/A cg19071035 chr6:20404090 E2F3 0.46 6.2 0.32 1.64e-9 Cognitive function; CRC cis rs1044826 0.642 rs6784684 chr3:139177634 T/C cg15131784 chr3:139108705 COPB2 0.39 5.69 0.3 2.79e-8 Obesity-related traits; CRC cis rs9393692 0.905 rs7746807 chr6:26293338 C/A cg05868516 chr6:26286170 HIST1H4H 0.39 5.62 0.3 3.99e-8 Educational attainment; CRC cis rs6908034 0.769 rs6916589 chr6:19761363 T/G cg02682789 chr6:19804855 NA 0.77 6.91 0.36 2.52e-11 Endometriosis;Deep ovarian and/or rectovaginal disease with dense adhesions; CRC cis rs10504229 0.609 rs56289889 chr8:58116276 G/C cg24829409 chr8:58192753 C8orf71 -0.55 -8.03 -0.4 1.71e-14 Developmental language disorder (linguistic errors); CRC cis rs11170631 0.504 rs12817180 chr12:54035448 A/G cg06632207 chr12:54070931 ATP5G2 0.46 7.8 0.4 8.19e-14 Height; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg04843900 chr20:16710618 SNRPB2 0.4 6.32 0.33 8.47e-10 Liver disease severity in Alagille syndrome; CRC cis rs9611565 0.512 rs139561 chr22:42195410 C/T cg03806693 chr22:41940476 POLR3H 1.06 12.9 0.58 4.18e-31 Vitiligo; CRC cis rs2204008 0.715 rs11514342 chr12:38236710 T/A cg26384229 chr12:38710491 ALG10B 0.68 9.08 0.45 9.92e-18 Bladder cancer; CRC cis rs10751667 1.000 rs7396366 chr11:986185 C/A cg23136738 chr11:925521 AP2A2 -0.51 -8.23 -0.41 4.51e-15 Alzheimer's disease (late onset); CRC cis rs2072510 0.593 rs2660892 chr12:96420978 T/C cg09636302 chr12:96389483 HAL -0.51 -6.18 -0.32 1.91e-9 Metabolite levels (small molecules and protein measures); CRC cis rs7666738 0.830 rs4699595 chr4:99012827 A/G cg05340658 chr4:99064831 C4orf37 0.62 9.64 0.47 1.5700000000000001e-19 Colonoscopy-negative controls vs population controls; CRC cis rs763014 0.932 rs2384972 chr16:674424 G/A cg08989290 chr16:615782 NHLRC4 0.48 9.29 0.46 2.13e-18 Height; CRC cis rs9549328 0.699 rs2993345 chr13:113617086 C/T cg08614441 chr13:113633676 MCF2L 0.4 7.12 0.37 6.75e-12 Systolic blood pressure; CRC cis rs9341808 0.718 rs2322636 chr6:80897436 C/T cg08355045 chr6:80787529 NA 0.43 6.95 0.36 1.94e-11 Sitting height ratio; CRC cis rs7683537 0.725 rs28837443 chr4:185641497 G/A cg04058563 chr4:185651563 MLF1IP 0.73 9.54 0.47 3.32e-19 Systemic lupus erythematosus; CRC cis rs6701037 0.555 rs10912898 chr1:175120469 A/G cg14847009 chr1:175162515 KIAA0040 -0.26 -5.83 -0.31 1.29e-8 Alcohol dependence; CRC cis rs951366 0.617 rs823075 chr1:205774897 C/T cg24503407 chr1:205819492 PM20D1 1.02 18.4 0.71 1.8e-52 Menarche (age at onset); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg27554769 chr1:202896170 KLHL12 0.41 6.0 0.31 5.09e-9 Intelligence (multi-trait analysis); CRC cis rs2274273 0.624 rs1972221 chr14:55785381 C/A cg10130446 chr14:55658398 DLGAP5 -0.41 -5.77 -0.3 1.87e-8 Protein biomarker; CRC cis rs7927771 1.000 rs12363232 chr11:47623890 C/T cg05585544 chr11:47624801 NA -0.63 -11.46 -0.53 8.57e-26 Subjective well-being; CRC cis rs11645898 0.935 rs17603936 chr16:72169002 C/A cg14768367 chr16:72042858 DHODH -0.59 -6.64 -0.34 1.28e-10 Blood protein levels; CRC cis rs7202877 0.706 rs247425 chr16:75460402 C/T cg03315344 chr16:75512273 CHST6 -0.53 -6.17 -0.32 2.04e-9 Type 2 diabetes;Type 1 diabetes; CRC trans rs2727020 0.688 rs2734002 chr11:49234162 A/G cg03929089 chr4:120376271 NA 0.79 13.11 0.59 6.84e-32 Coronary artery disease; CRC cis rs7264396 0.887 rs11698935 chr20:34075015 C/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.38 -6.33 -0.33 8.12e-10 Total cholesterol levels; CRC cis rs7918232 0.567 rs4749215 chr10:27312005 T/C cg14442939 chr10:27389572 ANKRD26 0.62 6.83 0.35 4.2e-11 Breast cancer; CRC trans rs3733585 0.699 rs4588456 chr4:9963895 A/T cg26043149 chr18:55253948 FECH -0.5 -7.62 -0.39 2.81e-13 Cleft plate (environmental tobacco smoke interaction); CRC cis rs4731207 0.623 rs4506149 chr7:124626473 G/A cg23710748 chr7:124431027 NA -0.4 -6.38 -0.33 6.15e-10 Cutaneous malignant melanoma; CRC cis rs6495122 0.618 rs4886413 chr15:75262310 G/C cg18612461 chr15:75251733 NA 0.48 7.26 0.37 2.88e-12 Caffeine consumption;Diastolic blood pressure;Coffee consumption; CRC cis rs8005677 1.000 rs7145494 chr14:23399790 T/C cg25600027 chr14:23388339 RBM23 -0.51 -7.88 -0.4 4.8e-14 Cognitive ability (multi-trait analysis); CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg26101466 chr14:64108700 WDR89 0.39 6.21 0.32 1.64e-9 Obesity-related traits; CRC cis rs3858526 0.834 rs10839166 chr11:6002464 T/C cg05234568 chr11:5960015 NA -0.47 -6.04 -0.32 4.11e-9 DNA methylation (variation); CRC cis rs7208859 0.725 rs6505215 chr17:29189903 C/A cg14008862 chr17:28927542 LRRC37B2 0.5 6.08 0.32 3.32e-9 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs12620999 0.941 rs10929215 chr2:238037456 G/A cg23555395 chr2:238036564 NA -0.62 -9.77 -0.47 5.93e-20 Systemic lupus erythematosus; CRC cis rs11166629 1.000 rs2315838 chr8:135645968 C/T cg27224718 chr8:135614730 ZFAT 0.51 7.53 0.38 5.02e-13 Smoking quantity; CRC cis rs1005277 0.579 rs2472178 chr10:38384750 T/C cg17219203 chr10:38645113 HSD17B7P2 -0.41 -5.96 -0.31 6.54e-9 Extrinsic epigenetic age acceleration; CRC cis rs477692 1.000 rs7475154 chr10:131440584 C/T cg05714579 chr10:131428358 MGMT -0.55 -7.89 -0.4 4.65e-14 Response to temozolomide; CRC cis rs2243480 1.000 rs10247526 chr7:65780696 T/G cg18252515 chr7:66147081 NA 1.28 14.93 0.64 7.56e-39 Diabetic kidney disease; CRC cis rs2625529 0.652 rs2929532 chr15:72345110 C/T cg16672083 chr15:72433130 SENP8 0.47 7.11 0.36 7.4e-12 Red blood cell count; CRC cis rs7772486 0.641 rs9390374 chr6:146368175 A/T cg05347473 chr6:146136440 FBXO30 0.48 7.12 0.37 6.87e-12 Lobe attachment (rater-scored or self-reported); CRC cis rs12431939 0.598 rs4268678 chr14:51736185 G/T cg23942311 chr14:51606299 NA 0.46 6.36 0.33 6.65e-10 Cancer; CRC cis rs10463316 0.817 rs6897109 chr5:150777738 T/C cg03212797 chr5:150827313 SLC36A1 -0.47 -7.24 -0.37 3.17e-12 Metabolite levels (Pyroglutamine); CRC cis rs4481887 1.000 rs4244182 chr1:248471174 A/G cg13385794 chr1:248469461 NA 0.36 6.34 0.33 7.63e-10 Common traits (Other); CRC cis rs25422 0.938 rs62421538 chr6:118729703 A/T cg07617317 chr6:118971624 C6orf204 0.52 6.45 0.34 3.9e-10 Renal cell carcinoma; CRC cis rs9914988 0.943 rs34693224 chr17:27079555 C/T cg16670446 chr17:27188758 MIR451;MIR144 0.53 8.4 0.42 1.4e-15 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs11148252 0.740 rs3803264 chr13:52971893 A/G cg02158880 chr13:53174818 NA -0.44 -6.31 -0.33 8.78e-10 Lewy body disease; CRC cis rs3087591 1.000 rs9904169 chr17:29572518 C/T cg24425628 chr17:29625626 OMG;NF1 -0.86 -16.79 -0.68 4.09e-46 Hip circumference; CRC cis rs17376456 0.877 rs10213956 chr5:93460839 C/T cg09848695 chr5:92956644 FAM172A;MIR2277 0.63 5.85 0.31 1.19e-8 Diabetic retinopathy; CRC cis rs798766 0.953 rs798751 chr4:1719572 A/G cg02089348 chr4:1724449 TMEM129;TACC3 -0.4 -5.64 -0.3 3.62e-8 Bladder cancer;Urinary bladder cancer; CRC cis rs7538876 0.903 rs730153 chr1:17749504 A/G cg07965774 chr1:17746286 RCC2 -0.34 -6.52 -0.34 2.7e-10 Basal cell carcinoma; CRC cis rs4713118 0.513 rs200971 chr6:27858904 C/T cg10876282 chr6:28092338 ZSCAN16 0.46 5.97 0.31 6.27e-9 Parkinson's disease; CRC cis rs7427021 0.537 rs7624003 chr3:163710060 T/C cg24587349 chr3:163632090 NA -0.36 -5.64 -0.3 3.65e-8 Bipolar disorder; CRC cis rs7618915 0.501 rs6617 chr3:52740182 C/G cg05573699 chr3:52720067 GNL3;PBRM1 -0.47 -6.91 -0.36 2.58e-11 Bipolar disorder; CRC cis rs6681460 0.966 rs7542924 chr1:67143055 C/T cg02459107 chr1:67143332 SGIP1 0.44 7.69 0.39 1.75e-13 Presence of antiphospholipid antibodies; CRC trans rs11098499 0.863 rs1552095 chr4:120460306 A/G cg25214090 chr10:38739885 LOC399744 0.68 10.46 0.5 2.72e-22 Corneal astigmatism; CRC cis rs916888 0.610 rs199454 chr17:44800110 G/A cg01570182 chr17:44337453 NA -0.69 -8.99 -0.44 1.96e-17 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs11628318 0.614 rs7143783 chr14:103128751 A/G cg08075719 chr14:103021372 NA 0.65 7.55 0.38 4.22e-13 Platelet count; CRC cis rs6938 0.597 rs11856413 chr15:75199892 A/G cg17294928 chr15:75287854 SCAMP5 0.54 8.11 0.41 1.04e-14 Breast cancer; CRC cis rs9858542 0.953 rs9827708 chr3:49649989 C/G cg03060546 chr3:49711283 APEH -0.5 -6.66 -0.34 1.14e-10 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs800160 0.844 rs2651784 chr11:2347549 C/T cg09785033 chr11:2336066 TSPAN32 -0.52 -5.92 -0.31 8.14e-9 Bacteremia; CRC cis rs9926296 0.508 rs1558184 chr16:89842374 T/G cg27121462 chr16:89883253 FANCA 0.59 9.43 0.46 7.83e-19 Vitiligo; CRC cis rs208520 0.802 rs4710315 chr6:66887594 A/G cg07460842 chr6:66804631 NA -0.93 -12.55 -0.57 8.48e-30 Exhaled nitric oxide output; CRC cis rs13082711 0.520 rs2643825 chr3:27562613 A/G cg02860705 chr3:27208620 NA 0.41 6.08 0.32 3.36e-9 Systolic blood pressure;Diastolic blood pressure;Blood pressure; CRC cis rs9372498 0.505 rs56406560 chr6:118991787 G/A cg15382696 chr6:118971807 C6orf204 0.48 6.28 0.33 1.06e-9 Diastolic blood pressure; CRC cis rs7178572 0.568 rs12912050 chr15:77689423 C/T cg22256960 chr15:77711686 NA -0.66 -9.6 -0.47 2.13e-19 Type 2 diabetes; CRC cis rs9649213 0.593 rs6945554 chr7:97972946 T/C cg24562669 chr7:97807699 LMTK2 0.44 7.37 0.38 1.35e-12 Prostate cancer (SNP x SNP interaction); CRC cis rs6951245 0.554 rs11761322 chr7:1151657 A/G cg26224354 chr7:1096374 C7orf50;GPR146 -0.58 -7.88 -0.4 4.8e-14 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC trans rs916888 0.779 rs199528 chr17:44843136 C/T cg23590916 chr17:43697445 MGC57346 0.71 6.93 0.36 2.25e-11 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC trans rs2403907 0.758 rs7275438 chr21:16568328 C/T cg00407105 chr4:90231041 NA -0.4 -6.1 -0.32 2.92e-9 Breast cancer; CRC cis rs6973256 0.897 rs763644 chr7:133343349 G/C cg10665199 chr7:133106180 EXOC4 -0.37 -5.75 -0.3 2.05e-8 Intelligence (multi-trait analysis); CRC cis rs12286929 0.839 rs11215375 chr11:115014002 C/T cg04055981 chr11:115044050 NA 0.36 5.87 0.31 1.06e-8 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs60871478 0.545 rs35400476 chr7:795686 A/G cg13844804 chr7:814759 HEATR2 0.63 8.14 0.41 8.33e-15 Cerebrospinal P-tau181p levels; CRC cis rs4332037 0.552 rs11773627 chr7:2002733 A/G cg02825527 chr7:2087843 MAD1L1 -0.45 -5.72 -0.3 2.4e-8 Bipolar disorder; CRC cis rs6741819 0.740 rs771266 chr2:7130931 A/G cg27144453 chr2:7172511 RNF144A -0.41 -6.07 -0.32 3.44e-9 Response to antipsychotic treatment; CRC cis rs10479542 0.784 rs6896940 chr5:178985994 G/C cg26516362 chr5:178986906 RUFY1 0.39 7.3 0.37 2.15e-12 Lung cancer; CRC cis rs79349575 0.681 rs56080003 chr17:47019049 A/T cg22482690 chr17:47019901 SNF8 0.48 8.01 0.4 2.01e-14 Type 2 diabetes; CRC cis rs6951245 0.580 rs78894484 chr7:1138721 T/G cg03188948 chr7:1209495 NA 0.49 5.75 0.3 2.03e-8 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs7666738 0.830 rs10014986 chr4:99000687 A/C cg05340658 chr4:99064831 C4orf37 0.61 9.54 0.47 3.44e-19 Colonoscopy-negative controls vs population controls; CRC cis rs1448094 0.511 rs10735486 chr12:86154352 T/A cg18827107 chr12:86230957 RASSF9 0.38 5.93 0.31 7.83e-9 Major depressive disorder; CRC cis rs7809950 0.637 rs3801964 chr7:106836242 T/C cg23024343 chr7:107201750 COG5 -0.74 -10.03 -0.48 7.62e-21 Coronary artery disease; CRC cis rs10540 1.000 rs35231079 chr11:515224 G/A cg21784768 chr11:537496 LRRC56 -0.7 -6.6 -0.34 1.65e-10 Body mass index; CRC cis rs2797160 1.000 rs4897152 chr6:126002400 A/G cg05901451 chr6:126070800 HEY2 -0.4 -6.08 -0.32 3.38e-9 Endometrial cancer; CRC cis rs3733585 0.624 rs58130873 chr4:9972081 T/C cg11266682 chr4:10021025 SLC2A9 -0.46 -9.17 -0.45 5.48e-18 Cleft plate (environmental tobacco smoke interaction); CRC cis rs7224685 0.774 rs8081417 chr17:3902650 T/A cg11204139 chr17:3907470 NA 0.74 12.35 0.56 4.69e-29 Type 2 diabetes; CRC trans rs1814175 0.817 rs6486044 chr11:49982718 C/T cg21153622 chr11:89784906 NA -0.37 -6.03 -0.32 4.33e-9 Height; CRC cis rs6502050 0.723 rs11650635 chr17:80083816 T/C cg13198984 chr17:80129470 CCDC57 -0.48 -8.56 -0.43 4.49e-16 Life satisfaction; CRC cis rs6754311 0.628 rs309811 chr2:136625602 A/G cg25344623 chr2:136566232 LCT 0.33 5.98 0.31 5.9e-9 Mosquito bite size; CRC cis rs427394 0.659 rs274725 chr5:6717408 C/G cg15145174 chr5:6755386 POLS -0.46 -6.78 -0.35 5.7e-11 Menopause (age at onset); CRC cis rs2806561 0.514 rs7519093 chr1:23541078 A/T cg19743168 chr1:23544995 NA -0.59 -8.68 -0.43 1.84e-16 Height; CRC cis rs3749237 0.555 rs7637665 chr3:49552295 T/C cg03060546 chr3:49711283 APEH 0.65 10.94 0.52 5.74e-24 Resting heart rate; CRC cis rs10274279 1.000 rs55941863 chr7:157372989 C/G cg26886268 chr7:157387156 PTPRN2 -0.46 -5.62 -0.3 4.07e-8 Myopia (pathological); CRC cis rs11098499 0.954 rs10024844 chr4:120311528 A/G cg09307838 chr4:120376055 NA 0.71 10.93 0.52 6.41e-24 Corneal astigmatism; CRC cis rs4926298 1.000 rs4926298 chr19:13153035 C/T cg04657146 chr19:12876947 HOOK2 -0.46 -6.13 -0.32 2.57e-9 Bipolar disorder; CRC cis rs9733 0.650 rs1971378 chr1:150597261 C/T cg18016565 chr1:150552671 MCL1 -0.46 -6.84 -0.35 3.89e-11 Tonsillectomy; CRC cis rs12523822 0.957 rs11970674 chr6:154955611 T/C cg20019720 chr6:154832845 CNKSR3 0.26 5.61 0.3 4.23e-8 Diabetic kidney disease; CRC trans rs7937682 0.921 rs1944119 chr11:111436387 A/G cg18187862 chr3:45730750 SACM1L -0.45 -5.97 -0.31 6.05e-9 Primary sclerosing cholangitis; CRC cis rs9611565 0.512 rs715498 chr22:42148467 G/A cg06481639 chr22:41940642 POLR3H 0.55 6.14 0.32 2.31e-9 Vitiligo; CRC trans rs2303319 0.504 rs56009150 chr2:162598582 T/C cg16699849 chr7:98923489 ARPC1A -0.68 -6.2 -0.32 1.66e-9 Cognitive function; CRC cis rs8078723 0.966 rs7021 chr17:38153875 T/A cg17467752 chr17:38218738 THRA 0.73 11.78 0.54 6.03e-27 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); CRC cis rs3733585 0.577 rs5014939 chr4:9953253 T/A cg11266682 chr4:10021025 SLC2A9 -0.47 -9.62 -0.47 1.76e-19 Cleft plate (environmental tobacco smoke interaction); CRC cis rs13144136 0.687 rs13119277 chr4:10658129 C/T cg10242279 chr4:10666415 CLNK -0.38 -6.5 -0.34 2.93e-10 Resistance to antihypertensive treatment in hypertension; CRC cis rs1018836 0.608 rs6982329 chr8:91467488 A/G cg16814680 chr8:91681699 NA -0.53 -8.19 -0.41 5.97e-15 Ejection fraction in Tripanosoma cruzi seropositivity; CRC cis rs7826238 0.564 rs2921053 chr8:8319963 G/C cg06636001 chr8:8085503 FLJ10661 0.62 9.83 0.48 3.75e-20 Systolic blood pressure; CRC cis rs34638657 0.518 rs4889467 chr16:82169385 C/T cg07918374 chr16:82182319 MPHOSPH6 0.41 5.91 0.31 8.39e-9 Lung adenocarcinoma; CRC cis rs13108904 0.901 rs12509700 chr4:1296321 A/G cg24560729 chr4:1342394 KIAA1530 0.35 6.42 0.33 4.64e-10 Obesity-related traits; CRC trans rs2980439 0.818 rs2945249 chr8:8094726 G/A cg16141378 chr3:129829833 LOC729375 -0.46 -6.61 -0.34 1.58e-10 Neuroticism; CRC cis rs2739330 0.828 rs5751770 chr22:24252842 A/G cg10819733 chr22:24237672 NA -0.37 -6.31 -0.33 8.99e-10 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs11122272 0.701 rs2749702 chr1:231523808 A/G cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.54 -8.14 -0.41 7.99e-15 Hemoglobin concentration; CRC cis rs559928 0.606 rs1011219 chr11:63973396 A/G cg19465662 chr11:63993652 NUDT22;TRPT1 -0.67 -6.66 -0.34 1.16e-10 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; CRC cis rs1965732 1.000 rs6707320 chr2:3708966 A/G cg19052272 chr2:3704530 ALLC -0.5 -6.97 -0.36 1.73e-11 Response to inhaled corticosteroid treatment in asthma (change in FEV1); CRC cis rs763121 0.752 rs5757222 chr22:39060473 C/T cg06544989 chr22:39130855 UNC84B 0.45 6.86 0.35 3.33e-11 Menopause (age at onset); CRC cis rs10256972 0.684 rs4724039 chr7:1111633 A/G cg23708337 chr7:1209742 NA 0.39 5.89 0.31 9.78e-9 Longevity;Endometriosis; CRC cis rs10865541 0.778 rs10779975 chr2:3420032 A/G cg22182287 chr2:3452347 TTC15 0.38 6.06 0.32 3.71e-9 Obesity-related traits; CRC trans rs2727020 0.612 rs9787891 chr11:49413494 G/A cg15704280 chr7:45808275 SEPT13 -0.81 -11.5 -0.54 6.09e-26 Coronary artery disease; CRC cis rs4481887 0.893 rs10888337 chr1:248428227 A/G cg00666640 chr1:248458726 OR2T12 -0.45 -7.92 -0.4 3.72e-14 Common traits (Other); CRC cis rs1983170 0.935 rs578155 chr1:91976541 G/A cg21854759 chr1:92012499 NA -0.51 -6.51 -0.34 2.82e-10 Eosinophil percentage of white cells; CRC trans rs7395662 0.824 rs12785858 chr11:48778806 A/G cg21153622 chr11:89784906 NA -0.48 -7.73 -0.39 1.28e-13 HDL cholesterol; CRC cis rs2976388 1.000 rs2572910 chr8:143770135 C/G cg04969067 chr8:143858791 LYNX1 -0.38 -6.39 -0.33 5.78e-10 Urinary tract infection frequency; CRC cis rs585510 1 rs585510 chr12:121000133 A/G cg27279351 chr12:120934652 DYNLL1 0.75 10.82 0.51 1.46e-23 Reticulocyte fraction of red cells; CRC cis rs8044868 0.586 rs6499557 chr16:72082654 A/G cg06172871 chr16:72088244 HP 0.44 6.45 0.33 4.08e-10 Body mass index (change over time) in cancer or chronic obstructive pulmonary disease;Body mass index (change over time) in cancer; CRC cis rs7937682 0.824 rs577044 chr11:111490420 G/T cg19812747 chr11:111475976 SIK2 -0.57 -9.79 -0.47 5.04e-20 Primary sclerosing cholangitis; CRC cis rs9341808 0.617 rs9294170 chr6:80814080 A/G cg08355045 chr6:80787529 NA 0.46 7.42 0.38 9.83e-13 Sitting height ratio; CRC cis rs7945705 0.875 rs11042059 chr11:8795080 G/A cg21881798 chr11:8931708 C11orf17;ST5 0.44 6.42 0.33 4.79e-10 Hemoglobin concentration; CRC cis rs6460942 0.524 rs6948366 chr7:12369905 A/G cg06484146 chr7:12443880 VWDE -0.56 -7.6 -0.39 3.15e-13 Coronary artery disease; CRC cis rs9733 0.525 rs11584184 chr1:150695689 A/T cg18016565 chr1:150552671 MCL1 0.45 6.52 0.34 2.57e-10 Tonsillectomy; CRC cis rs6087990 0.735 rs6087420 chr20:31359391 G/A cg13636640 chr20:31349939 DNMT3B 0.82 16.77 0.68 4.92e-46 Ulcerative colitis; CRC cis rs2303759 0.709 rs8102574 chr19:49828897 A/G cg22307029 chr19:49891270 CCDC155 0.68 8.94 0.44 2.78e-17 Multiple sclerosis; CRC cis rs6547741 1.000 rs1919126 chr2:27801418 C/A cg27432699 chr2:27873401 GPN1 0.76 13.58 0.6 1.2e-33 Oral cavity cancer; CRC cis rs6499255 1.000 rs4078387 chr16:69814047 G/A cg00738113 chr16:70207722 CLEC18C -0.43 -6.12 -0.32 2.62e-9 IgE levels; CRC trans rs2303319 0.504 rs62189051 chr2:162622318 G/A cg13490827 chr1:46269305 MAST2 -0.68 -5.99 -0.31 5.44e-9 Cognitive function; CRC trans rs4689592 0.523 rs3857179 chr4:7070496 T/A cg07817883 chr1:32538562 TMEM39B -0.62 -7.75 -0.39 1.12e-13 Monocyte percentage of white cells; CRC cis rs6952808 1.000 rs6952808 chr7:1886535 C/G cg21782813 chr7:2030301 MAD1L1 0.38 6.53 0.34 2.46e-10 Bipolar disorder and schizophrenia; CRC cis rs11098499 0.909 rs10020034 chr4:120294331 A/G cg24375607 chr4:120327624 NA 0.51 7.78 0.39 9.48e-14 Corneal astigmatism; CRC cis rs1448094 0.511 rs10506918 chr12:86227913 A/G cg18827107 chr12:86230957 RASSF9 0.44 7.29 0.37 2.3e-12 Major depressive disorder; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg06527052 chr1:109633875 TMEM167B 0.42 6.39 0.33 5.59e-10 Liver disease severity in Alagille syndrome; CRC cis rs10751667 0.666 rs7396509 chr11:956761 G/A cg23136738 chr11:925521 AP2A2 -0.43 -7.27 -0.37 2.66e-12 Alzheimer's disease (late onset); CRC cis rs10504229 0.775 rs17216236 chr8:58159352 G/A cg08219700 chr8:58056026 NA 0.46 5.78 0.3 1.7e-8 Developmental language disorder (linguistic errors); CRC cis rs7647973 0.667 rs11721148 chr3:49646669 G/A cg03060546 chr3:49711283 APEH 0.64 7.54 0.38 4.52e-13 Menarche (age at onset); CRC cis rs7493 1.000 rs7493 chr7:95034775 C/G cg17330251 chr7:94953956 PON1 0.56 7.21 0.37 3.96e-12 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs853679 0.517 rs9348793 chr6:28084189 G/A cg12963246 chr6:28129442 ZNF389 0.5 5.8 0.3 1.53e-8 Depression; CRC cis rs6951245 0.638 rs4720486 chr7:1146764 G/A cg21664854 chr7:1097933 C7orf50;GPR146 0.58 7.31 0.37 2.05e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs875971 1.000 rs6946143 chr7:65579722 A/C cg00343986 chr7:65444356 GUSB 0.44 6.64 0.34 1.28e-10 Aortic root size; CRC cis rs6951245 0.872 rs77569514 chr7:1085508 G/A cg08132940 chr7:1081526 C7orf50 -0.54 -5.67 -0.3 3.04e-8 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs4975709 0.589 rs1684967 chr5:1863055 G/C cg14773178 chr5:1868261 NA 0.34 6.02 0.31 4.75e-9 Cardiovascular disease risk factors; CRC cis rs7542091 0.813 rs2049999 chr1:210031331 A/G cg23283495 chr1:209979779 IRF6 0.34 6.04 0.32 4.07e-9 Monobrow; CRC cis rs909002 0.800 rs3134718 chr1:32089839 C/T cg13919466 chr1:32135498 COL16A1 -0.31 -5.9 -0.31 8.97e-9 Intelligence (multi-trait analysis); CRC trans rs561341 0.609 rs9906443 chr17:30185565 C/T cg20587970 chr11:113659929 NA 0.69 8.66 0.43 2.21e-16 Hip circumference adjusted for BMI; CRC trans rs7757969 0.500 rs10440852 chr6:112157020 G/C cg08211895 chr2:48828358 STON1-GTF2A1L 0.31 6.07 0.32 3.57e-9 Schizophrenia; CRC cis rs7959452 0.640 rs10878957 chr12:69699638 G/C cg22834771 chr12:69754056 YEATS4 -0.4 -5.75 -0.3 2.05e-8 Blood protein levels; CRC cis rs9322193 0.923 rs7753812 chr6:150011286 C/T cg13206674 chr6:150067644 NUP43 0.57 8.27 0.41 3.37e-15 Lung cancer; CRC trans rs208520 0.837 rs208488 chr6:66926902 C/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.93 -12.01 -0.55 8.16e-28 Exhaled nitric oxide output; CRC cis rs9987353 0.544 rs2929470 chr8:9062490 A/G cg06636001 chr8:8085503 FLJ10661 -0.47 -7.45 -0.38 8.36e-13 Recombination measurement; CRC cis rs17067123 0.614 rs6857116 chr4:180062542 G/A cg26610307 chr4:180072759 NA -0.52 -5.93 -0.31 7.73e-9 Response to hepatitis C treatment; CRC cis rs3131513 0.965 rs7513516 chr1:25193009 C/T cg22509179 chr1:25234806 RUNX3 -0.42 -6.46 -0.34 3.72e-10 Alcohol dependence; CRC cis rs17401966 0.577 rs1556915 chr1:10242654 A/G cg19773385 chr1:10388646 KIF1B -0.48 -7.37 -0.38 1.4e-12 Hepatocellular carcinoma; CRC cis rs8105895 0.935 rs10407173 chr19:22246663 C/T cg02657401 chr19:22469223 NA -0.34 -5.65 -0.3 3.56e-8 Body mass index (change over time); CRC cis rs6502050 0.835 rs10163483 chr17:80110396 C/A cg13198984 chr17:80129470 CCDC57 0.46 8.16 0.41 6.94e-15 Life satisfaction; CRC cis rs2276314 1.000 rs4799834 chr18:33566243 T/C cg19628046 chr18:33552617 C18orf21 0.5 6.86 0.35 3.52e-11 Endometriosis;Drug-induced torsades de pointes; CRC cis rs7762018 1.000 rs74900588 chr6:170102180 A/C cg17545662 chr6:170176663 C6orf70 0.53 5.86 0.31 1.12e-8 Thiazide-induced adverse metabolic effects in hypertensive patients; CRC cis rs9517320 1.000 rs9645890 chr13:99126637 C/T cg20487152 chr13:99095054 FARP1 0.36 5.93 0.31 7.65e-9 Longevity; CRC cis rs853679 0.517 rs9380065 chr6:28144751 A/G cg02683197 chr6:28174875 NA 0.88 10.83 0.51 1.42e-23 Depression; CRC cis rs2949837 0.504 rs2342396 chr7:45968087 C/G cg10677697 chr7:45961126 IGFBP3 0.33 5.89 0.31 9.31e-9 Sitting height ratio; CRC cis rs2404602 0.967 rs2083762 chr15:76907376 T/C cg03037974 chr15:76606532 NA 0.6 10.09 0.49 4.85e-21 Blood metabolite levels; CRC cis rs4268898 0.760 rs11676939 chr2:24479057 C/T cg06627628 chr2:24431161 ITSN2 0.42 6.05 0.32 3.97e-9 Asthma; CRC cis rs728616 0.867 rs61860044 chr10:81946538 C/G cg11900509 chr10:81946545 ANXA11 -0.71 -7.22 -0.37 3.73e-12 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs6502050 0.749 rs7209948 chr17:80086804 T/G cg09264619 chr17:80180166 NA 0.36 6.07 0.32 3.45e-9 Life satisfaction; CRC cis rs4499344 0.604 rs259287 chr19:33164859 C/T cg08127369 chr19:33164662 ANKRD27 0.39 6.01 0.31 5.02e-9 Mean platelet volume; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg12900929 chr12:108154862 PRDM4 0.36 6.77 0.35 5.89e-11 Liver disease severity in Alagille syndrome; CRC cis rs875971 0.862 rs778697 chr7:65870426 G/A cg12463550 chr7:65579703 CRCP 0.48 6.52 0.34 2.72e-10 Aortic root size; CRC cis rs17021463 0.643 rs6841656 chr4:95300532 A/G cg11021082 chr4:95130006 SMARCAD1 0.44 6.42 0.33 4.72e-10 Testicular germ cell tumor; CRC cis rs35995292 0.553 rs2392605 chr7:38924670 T/C cg19327137 chr7:38886074 VPS41 0.65 10.83 0.51 1.4e-23 Subjective well-being (multi-trait analysis); CRC cis rs6540556 0.723 rs1000283 chr1:209894661 A/G cg05527609 chr1:210001259 C1orf107 0.57 6.23 0.32 1.43e-9 Red blood cell count; CRC cis rs4824093 0.610 rs12106611 chr22:50242686 G/A cg22709217 chr22:50311962 ALG12;CRELD2 -0.95 -8.33 -0.42 2.2e-15 Amyotrophic lateral sclerosis (sporadic); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg09251771 chr6:10695336 C6orf52;PAK1IP1 0.39 5.96 0.31 6.43e-9 Liver disease severity in Alagille syndrome; CRC cis rs12497850 0.931 rs62262517 chr3:49134914 T/G cg20833759 chr3:49053208 WDR6;DALRD3 0.51 8.52 0.43 5.93e-16 Parkinson's disease; CRC cis rs950169 0.579 rs881983 chr15:84647308 C/T cg17507749 chr15:85114479 UBE2QP1 0.61 8.3 0.42 2.82e-15 Schizophrenia; CRC cis rs7191439 0.674 rs4782430 chr16:88792047 A/G cg02389323 chr16:88786976 FAM38A 0.88 8.82 0.44 6.71e-17 Plateletcrit; CRC cis rs1784581 0.588 rs9346894 chr6:162430763 T/C cg17173639 chr6:162384350 PARK2 0.59 9.39 0.46 1.04e-18 Itch intensity from mosquito bite; CRC cis rs6921919 0.583 rs6922169 chr6:28382932 G/A cg21251018 chr6:28226885 NKAPL 0.4 5.99 0.31 5.41e-9 Autism spectrum disorder or schizophrenia; CRC cis rs7769051 1.000 rs6934161 chr6:133124077 C/T cg22852734 chr6:133119734 C6orf192 -0.99 -11.99 -0.55 1.03e-27 Type 2 diabetes nephropathy; CRC cis rs1552244 0.572 rs41464050 chr3:10158393 A/G cg00166722 chr3:10149974 C3orf24 0.64 7.58 0.39 3.65e-13 Alzheimer's disease; CRC cis rs6582630 0.502 rs11520278 chr12:38359642 T/A cg13010199 chr12:38710504 ALG10B 0.45 5.76 0.3 1.96e-8 Drug-induced liver injury (flucloxacillin); CRC cis rs8067545 0.641 rs860335 chr17:19837679 A/G cg04132472 chr17:19861366 AKAP10 0.43 6.55 0.34 2.19e-10 Schizophrenia; CRC cis rs2836950 0.565 rs8130320 chr21:40580258 C/T cg11890956 chr21:40555474 PSMG1 -0.65 -10.0 -0.48 9.8e-21 Menarche (age at onset); CRC trans rs11039798 0.511 rs2047812 chr11:48162042 A/G cg03929089 chr4:120376271 NA -0.68 -7.26 -0.37 2.73e-12 Axial length; CRC cis rs7605827 0.538 rs62120660 chr2:15659613 T/C cg19274914 chr2:15703543 NA 0.39 5.86 0.31 1.13e-8 Educational attainment (years of education); CRC trans rs7726839 0.574 rs12517345 chr5:628294 G/A cg25482853 chr8:67687455 SGK3 1.11 12.99 0.58 2.06e-31 Obesity-related traits; CRC cis rs7647973 0.961 rs4955417 chr3:49298205 T/C cg07690219 chr3:49449608 TCTA;RHOA -0.51 -5.96 -0.31 6.64e-9 Menarche (age at onset); CRC cis rs4664293 0.867 rs6432557 chr2:160592210 A/G cg08347373 chr2:160653686 CD302 -0.47 -7.43 -0.38 9.32e-13 Monocyte percentage of white cells; CRC cis rs911119 0.913 rs67483168 chr20:23581312 T/C cg16589663 chr20:23618590 CST3 0.53 6.37 0.33 6.19e-10 Chronic kidney disease; CRC cis rs12745968 0.620 rs7535490 chr1:93061849 C/T cg17283838 chr1:93427260 FAM69A -0.48 -6.57 -0.34 1.97e-10 Bipolar disorder and schizophrenia; CRC cis rs4731207 0.671 rs4731221 chr7:124481403 T/A cg23710748 chr7:124431027 NA 0.38 6.1 0.32 2.96e-9 Cutaneous malignant melanoma; CRC cis rs4969178 0.930 rs2292644 chr17:76394449 C/T cg05887092 chr17:76393375 PGS1 0.55 10.17 0.49 2.62e-21 HDL cholesterol levels; CRC cis rs727563 0.593 rs5758461 chr22:42162189 G/C cg06634786 chr22:41940651 POLR3H 0.66 7.3 0.37 2.18e-12 Crohn's disease;Inflammatory bowel disease; CRC cis rs6088580 0.524 rs6088569 chr20:33268199 G/A cg08999081 chr20:33150536 PIGU -0.38 -5.69 -0.3 2.85e-8 Glomerular filtration rate (creatinine); CRC cis rs617791 0.530 rs735942 chr11:65749337 A/G cg27068330 chr11:65405492 SIPA1 -0.47 -6.57 -0.34 2.02e-10 Breast cancer; CRC cis rs801193 1.000 rs2707856 chr7:66211010 A/T cg05627663 chr7:65219948 SNORA22;CCT6P1 0.42 6.13 0.32 2.58e-9 Aortic root size; CRC trans rs11098499 0.754 rs12506610 chr4:120241659 T/C cg25214090 chr10:38739885 LOC399744 0.53 8.36 0.42 1.78e-15 Corneal astigmatism; CRC cis rs933688 1.000 rs1964292 chr5:90743608 T/C cg26981201 chr5:90679533 LOC100129716;ARRDC3 0.98 15.01 0.64 3.59e-39 Smoking behavior; CRC cis rs17162190 0.698 rs12094989 chr1:26848386 A/G cg17456097 chr1:26900765 RPS6KA1 -0.42 -5.89 -0.31 9.37e-9 Mean corpuscular volume; CRC trans rs116095464 0.558 rs56342538 chr5:225796 T/C cg00938859 chr5:1591904 SDHAP3 0.7 7.63 0.39 2.58e-13 Breast cancer; CRC cis rs9611565 0.659 rs73178626 chr22:41928371 T/G cg06481639 chr22:41940642 POLR3H -0.53 -6.06 -0.32 3.64e-9 Vitiligo; CRC cis rs3796352 1.000 rs11710707 chr3:52975916 A/G cg06204229 chr3:52865917 ITIH4 0.5 5.74 0.3 2.19e-8 Immune reponse to smallpox (secreted IL-2); CRC cis rs599083 0.530 rs2508834 chr11:68175354 C/T cg01657329 chr11:68192670 LRP5 0.47 6.95 0.36 1.96e-11 Bone mineral density (spine); CRC cis rs4664293 0.551 rs11898293 chr2:160552593 T/C cg08347373 chr2:160653686 CD302 0.39 6.52 0.34 2.6200000000000003e-10 Monocyte percentage of white cells; CRC cis rs1865760 0.622 rs9295685 chr6:26071725 G/C cg18357526 chr6:26021779 HIST1H4A 0.43 6.05 0.32 3.88e-9 Height; CRC cis rs1707322 0.752 rs28719889 chr1:46202283 C/T cg06784218 chr1:46089804 CCDC17 0.65 12.0 0.55 8.83e-28 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs9311676 0.632 rs56033718 chr3:58446398 A/G cg06643156 chr3:58380774 PXK 0.43 6.66 0.34 1.16e-10 Systemic lupus erythematosus; CRC cis rs6089584 0.706 rs6089625 chr20:60620622 T/C cg18761221 chr20:60518478 NA 0.44 7.07 0.36 9.54e-12 Body mass index; CRC cis rs6120849 0.754 rs7268266 chr20:33581889 T/C cg24642439 chr20:33292090 TP53INP2 0.43 5.65 0.3 3.52e-8 Protein C levels; CRC cis rs4481887 0.927 rs4460676 chr1:248431781 G/A cg13385794 chr1:248469461 NA 0.41 7.06 0.36 9.96e-12 Common traits (Other); CRC trans rs2727020 0.729 rs10839283 chr11:49490943 T/C cg11707556 chr5:10655725 ANKRD33B 0.37 6.26 0.33 1.21e-9 Coronary artery disease; CRC cis rs738322 0.742 rs4821767 chr22:38614129 G/T cg17652424 chr22:38574118 PLA2G6 0.2 5.78 0.3 1.71e-8 Cutaneous nevi; CRC trans rs7615952 0.512 rs2979336 chr3:125357470 G/A cg02560186 chr11:3602584 NA -0.62 -9.33 -0.46 1.65e-18 Blood pressure (smoking interaction); CRC cis rs9359856 0.636 rs4706345 chr6:90301565 C/T cg13799429 chr6:90582589 CASP8AP2 -0.61 -8.25 -0.41 3.85e-15 Bipolar disorder; CRC cis rs9372498 0.536 rs9489458 chr6:118920503 G/A cg24463073 chr6:118973353 C6orf204 0.51 6.73 0.35 7.61e-11 Diastolic blood pressure; CRC cis rs34779708 0.931 rs12248333 chr10:35362977 A/G cg03585969 chr10:35415529 CREM 0.6 8.13 0.41 8.81e-15 Inflammatory bowel disease;Crohn's disease; CRC cis rs2297440 0.530 rs34533955 chr20:62233020 A/C cg06363034 chr20:62225388 GMEB2 -0.44 -6.56 -0.34 2.15e-10 Glioma;Non-glioblastoma glioma;Glioblastoma; CRC cis rs6840360 0.642 rs2709828 chr4:152355268 C/T cg09659197 chr4:152720779 NA 0.34 6.66 0.34 1.14e-10 Intelligence (multi-trait analysis); CRC cis rs9649213 0.555 rs6956686 chr7:97997945 T/C cg00277769 chr7:97922759 BAIAP2L1 -0.6 -10.38 -0.5 4.9e-22 Prostate cancer (SNP x SNP interaction); CRC cis rs10791097 0.967 rs1944142 chr11:130717440 C/T cg12179176 chr11:130786555 SNX19 0.56 8.25 0.41 3.78e-15 Autism spectrum disorder or schizophrenia;Schizophrenia; CRC cis rs6456156 0.603 rs2345754 chr6:167484361 T/C cg07741184 chr6:167504864 NA 0.38 6.65 0.34 1.21e-10 Primary biliary cholangitis; CRC cis rs11971779 0.680 rs11980313 chr7:139034643 C/G cg07862535 chr7:139043722 LUC7L2 0.57 7.35 0.38 1.55e-12 Diisocyanate-induced asthma; CRC cis rs7493 0.901 rs11764079 chr7:95026229 A/G cg01874867 chr7:94954059 PON1 0.41 5.93 0.31 7.56e-9 Yu-Zhi constitution type in type 2 diabetes; CRC trans rs561341 0.883 rs1034627 chr17:30219569 C/T cg20587970 chr11:113659929 NA -0.73 -8.91 -0.44 3.53e-17 Hip circumference adjusted for BMI; CRC cis rs6951245 1.000 rs78143408 chr7:1096846 G/A cg21664854 chr7:1097933 C7orf50;GPR146 0.78 8.81 0.44 7.57e-17 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs9462846 0.725 rs6927188 chr6:42912589 C/T cg27588902 chr6:42928151 GNMT 0.38 5.74 0.3 2.11e-8 Blood protein levels; CRC cis rs77633900 0.772 rs157778 chr15:76759444 G/C cg21673338 chr15:77095150 SCAPER -0.67 -6.17 -0.32 2e-9 Non-glioblastoma glioma;Glioma; CRC cis rs875971 0.798 rs12698522 chr7:65967341 T/C cg18252515 chr7:66147081 NA -0.43 -6.11 -0.32 2.84e-9 Aortic root size; CRC trans rs3733585 0.673 rs7672947 chr4:9961368 G/C cg26043149 chr18:55253948 FECH -0.49 -7.52 -0.38 5.26e-13 Cleft plate (environmental tobacco smoke interaction); CRC trans rs1814175 0.527 rs10769595 chr11:49638212 A/G cg03929089 chr4:120376271 NA -0.73 -10.01 -0.48 8.9e-21 Height; CRC trans rs3780486 0.629 rs10971439 chr9:33180813 C/T cg04842962 chr6:43655489 MRPS18A -0.89 -10.46 -0.5 2.76e-22 IgG glycosylation; CRC cis rs4743820 0.503 rs10820834 chr9:93917440 C/T cg14446406 chr9:93919335 NA -0.46 -7.89 -0.4 4.41e-14 Ulcerative colitis;Inflammatory bowel disease; CRC cis rs12541635 0.899 rs1429676 chr8:107065790 G/A cg10147462 chr8:107024639 NA -0.42 -7.13 -0.37 6.54e-12 Age of smoking initiation; CRC cis rs2276314 0.553 rs1789501 chr18:33617060 T/A cg05985134 chr18:33552581 C18orf21 -0.39 -6.03 -0.32 4.38e-9 Endometriosis;Drug-induced torsades de pointes; CRC cis rs921968 0.541 rs2710246 chr2:219533894 C/T cg02176678 chr2:219576539 TTLL4 0.52 8.37 0.42 1.63e-15 Mean corpuscular hemoglobin concentration; CRC cis rs10197940 0.624 rs4461258 chr2:152429679 A/G cg06191203 chr2:152266755 RIF1 0.65 9.28 0.46 2.32e-18 Lung cancer; CRC cis rs7927592 0.913 rs7106010 chr11:68365212 C/T cg01657329 chr11:68192670 LRP5 -0.49 -7.09 -0.36 8.28e-12 Total body bone mineral density; CRC cis rs3091242 0.900 rs1883427 chr1:25744468 C/T cg27572855 chr1:25598939 RHD 0.36 6.46 0.34 3.79e-10 Erythrocyte sedimentation rate; CRC cis rs853679 0.517 rs9393898 chr6:28130376 G/T cg15845792 chr6:28175446 NA 1.04 13.81 0.61 1.6e-34 Depression; CRC cis rs4925540 0.962 rs6689229 chr1:247241636 C/T cg22502715 chr1:247171572 ZNF695 0.43 5.68 0.3 3.04e-8 Response to taxane treatment (docetaxel); CRC trans rs875971 0.660 rs2191268 chr7:66110224 C/T cg21961583 chr2:170684455 UBR3 -0.39 -6.0 -0.31 5.34e-9 Aortic root size; CRC cis rs6121246 0.909 rs6060812 chr20:30292803 C/T cg13852791 chr20:30311386 BCL2L1 0.69 11.04 0.52 2.47e-24 Mean corpuscular hemoglobin; CRC cis rs8177253 1.000 rs8177261 chr3:133480588 A/C cg11941060 chr3:133502564 NA -0.59 -10.21 -0.49 1.99e-21 Iron status biomarkers; CRC cis rs9462027 0.651 rs6940395 chr6:34736553 G/T cg07306190 chr6:34760872 UHRF1BP1 -0.35 -6.26 -0.33 1.18e-9 Systemic lupus erythematosus; CRC cis rs703842 1.000 rs10431505 chr12:58178589 A/G cg00677455 chr12:58241039 CTDSP2 0.67 9.42 0.46 8.41e-19 Multiple sclerosis; CRC cis rs12545109 0.800 rs1996105 chr8:57413123 A/G cg09654669 chr8:57350985 NA -0.4 -5.68 -0.3 2.99e-8 Obesity-related traits; CRC cis rs35883536 0.967 rs9434126 chr1:101106981 A/G cg14515779 chr1:101123966 NA 0.4 7.57 0.38 3.91e-13 Monocyte count; CRC cis rs4862750 0.832 rs6419953 chr4:187900509 T/A cg03647317 chr4:187891568 NA -0.54 -10.28 -0.49 1.09e-21 Lobe attachment (rater-scored or self-reported); CRC cis rs2011503 1.000 rs74950305 chr19:19639448 C/T cg11584989 chr19:19387371 SF4 0.59 6.53 0.34 2.48e-10 Bipolar disorder; CRC cis rs995000 0.931 rs1168013 chr1:62996838 C/G cg19896129 chr1:63156450 NA 0.41 6.44 0.33 4.12e-10 Triglyceride levels; CRC cis rs2070488 0.775 rs4371464 chr3:38548021 T/C cg01465620 chr3:38496096 LOC100128640;ACVR2B -0.7 -12.01 -0.55 8.36e-28 Electrocardiographic conduction measures; CRC trans rs1814175 0.817 rs1794164 chr11:49899610 T/C cg21153622 chr11:89784906 NA -0.38 -6.05 -0.32 3.83e-9 Height; CRC cis rs1448094 0.511 rs4492889 chr12:86146735 C/A cg18827107 chr12:86230957 RASSF9 0.39 5.96 0.31 6.52e-9 Major depressive disorder; CRC cis rs12887734 0.546 rs66676135 chr14:104271504 G/A cg08213375 chr14:104286397 PPP1R13B 0.48 8.0 0.4 2.2e-14 Schizophrenia;Autism spectrum disorder or schizophrenia; CRC cis rs1059312 1.000 rs7970815 chr12:129288366 G/A cg09035930 chr12:129282057 SLC15A4 0.55 9.19 0.45 4.48e-18 Systemic lupus erythematosus; CRC cis rs875971 0.540 rs1723268 chr7:65473080 A/C cg05627663 chr7:65219948 SNORA22;CCT6P1 0.5 7.34 0.38 1.68e-12 Aortic root size; CRC cis rs2439831 0.867 rs12443102 chr15:43932103 G/C cg15269541 chr15:43626905 ADAL -0.49 -5.63 -0.3 3.86e-8 Lung cancer in ever smokers; CRC cis rs1008375 1.000 rs28552744 chr4:17620165 A/G cg04450456 chr4:17643702 FAM184B 0.37 6.09 0.32 3.11e-9 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs734999 0.545 rs6698817 chr1:2564183 T/C cg20673091 chr1:2541236 MMEL1 -0.36 -5.68 -0.3 2.99e-8 Ulcerative colitis; CRC cis rs7044106 0.791 rs4836830 chr9:123483668 A/G cg09419670 chr9:123605666 PSMD5;LOC253039 0.78 12.79 0.58 1.12e-30 Hip circumference adjusted for BMI; CRC cis rs1552244 1.000 rs1552244 chr3:10135577 A/G cg13047869 chr3:10149882 C3orf24 0.51 7.1 0.36 7.76e-12 Alzheimer's disease; CRC cis rs2019137 0.936 rs12612729 chr2:113957048 G/A cg21610815 chr2:113994035 PAX8;LOC654433;LOC440839 -0.45 -6.28 -0.33 1.07e-9 Lymphocyte counts; CRC trans rs3942852 0.726 rs10742836 chr11:48175831 G/A cg15704280 chr7:45808275 SEPT13 -0.75 -9.35 -0.46 1.43e-18 Acute lymphoblastic leukemia (childhood); CRC cis rs2243480 0.711 rs2460426 chr7:65623129 A/G cg25985355 chr7:65971099 NA 0.52 6.01 0.31 4.91e-9 Diabetic kidney disease; CRC cis rs2880765 0.835 rs7162502 chr15:86044473 G/T cg17133734 chr15:86042851 AKAP13 0.42 6.76 0.35 6.41e-11 Coronary artery disease; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg19587779 chr20:34638023 LOC647979 0.4 6.55 0.34 2.21e-10 Liver disease severity in Alagille syndrome; CRC cis rs1005277 0.522 rs11011343 chr10:38002698 A/G cg25517755 chr10:38738941 LOC399744 -0.43 -6.29 -0.33 1e-9 Extrinsic epigenetic age acceleration; CRC cis rs11155671 0.517 rs9397058 chr6:150207249 C/T cg13206674 chr6:150067644 NUP43 0.48 6.95 0.36 1.93e-11 Testicular germ cell tumor; CRC cis rs4731207 0.596 rs11761669 chr7:124586301 C/T cg23710748 chr7:124431027 NA 0.38 6.09 0.32 3.19e-9 Cutaneous malignant melanoma; CRC cis rs9470366 0.527 rs10807170 chr6:36629444 C/T cg08179530 chr6:36648295 CDKN1A -0.56 -8.34 -0.42 2.13e-15 QRS duration; CRC cis rs10927875 0.800 rs1627145 chr1:16328116 C/T cg21385522 chr1:16154831 NA 0.64 8.26 0.41 3.72e-15 Dilated cardiomyopathy; CRC cis rs709400 0.859 rs942863 chr14:104021268 C/T cg01849466 chr14:104193079 ZFYVE21 0.42 6.41 0.33 4.95e-10 Body mass index; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg18909525 chr9:132403873 ASB6 0.47 6.25 0.33 1.24e-9 Thyroid stimulating hormone; CRC trans rs1908814 0.516 rs11250178 chr8:11800234 A/C cg08975724 chr8:8085496 FLJ10661 0.4 6.05 0.32 4.04e-9 Neuroticism; CRC cis rs3008870 0.958 rs34367328 chr1:67445321 T/C cg08660285 chr1:67390436 MIER1;WDR78 -1.04 -15.24 -0.64 4.66e-40 Lymphocyte percentage of white cells; CRC cis rs11190604 1.000 rs3750627 chr10:102275642 G/T cg16342193 chr10:102329863 NA -0.35 -5.96 -0.31 6.56e-9 Palmitoleic acid (16:1n-7) levels; CRC cis rs877282 0.945 rs11253397 chr10:789774 A/G cg06581033 chr10:766294 NA -0.51 -5.68 -0.3 2.97e-8 Uric acid levels; CRC trans rs1265507 0.599 rs2077196 chr12:114869757 G/T cg11700868 chr17:38521232 GJD3 0.42 5.99 0.31 5.5e-9 Percent mammographic density; CRC cis rs9527 0.615 rs3897401 chr10:104696379 T/C cg04362960 chr10:104952993 NT5C2 0.6 8.59 0.43 3.61e-16 Arsenic metabolism; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg17841529 chr12:76953712 OSBPL8 0.43 6.01 0.31 4.85e-9 Response to antipsychotic treatment; CRC cis rs62229266 0.804 rs56279140 chr21:37424361 C/T cg08632701 chr21:37451849 NA -0.45 -7.11 -0.36 7.42e-12 Mitral valve prolapse; CRC trans rs11039798 0.588 rs3924476 chr11:48581733 T/C cg15704280 chr7:45808275 SEPT13 0.65 7.01 0.36 1.36e-11 Axial length; CRC cis rs10504229 0.815 rs16921955 chr8:58164553 C/T cg22535103 chr8:58192502 C8orf71 -0.7 -10.65 -0.51 5.71e-23 Developmental language disorder (linguistic errors); CRC cis rs10504229 0.679 rs12679941 chr8:58051812 G/T cg22535103 chr8:58192502 C8orf71 -0.55 -6.85 -0.35 3.55e-11 Developmental language disorder (linguistic errors); CRC cis rs11677416 1.000 rs6542093 chr2:113528536 G/A cg27083787 chr2:113543245 IL1A 0.44 6.35 0.33 7.26e-10 Response to antipsychotic treatment in schizophrenia (working memory); CRC cis rs4474465 0.688 rs10899553 chr11:78265210 A/G cg02023728 chr11:77925099 USP35 -0.36 -6.16 -0.32 2.16e-9 Alzheimer's disease (survival time); CRC cis rs4731207 0.536 rs10254199 chr7:124655116 C/T cg23710748 chr7:124431027 NA -0.43 -6.87 -0.35 3.19e-11 Cutaneous malignant melanoma; CRC cis rs2013441 1.000 rs2703799 chr17:20085768 G/T cg13482628 chr17:19912719 NA -0.39 -5.96 -0.31 6.45e-9 Obesity-related traits; CRC cis rs7216064 1.000 rs11079706 chr17:65835470 G/T cg12091567 chr17:66097778 LOC651250 -0.69 -7.99 -0.4 2.35e-14 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CRC cis rs6938 0.534 rs12913293 chr15:75184458 G/C cg14664628 chr15:75095509 CSK -0.65 -10.6 -0.5 8.65e-23 Breast cancer; CRC cis rs853679 0.517 rs9380057 chr6:28104634 G/T cg15786705 chr6:28176104 NA 0.77 9.75 0.47 6.92e-20 Depression; CRC cis rs4713118 0.699 rs573179 chr6:27849676 C/A cg06470822 chr6:28175283 NA 0.83 11.06 0.52 2.15e-24 Parkinson's disease; CRC cis rs8062405 0.823 rs7202948 chr16:28558289 T/A cg05139728 chr16:28306816 SBK1 -0.34 -5.79 -0.3 1.62e-8 Cognitive ability (multi-trait analysis);Cognitive ability; CRC cis rs6860806 0.507 rs274572 chr5:131710917 T/G cg18758796 chr5:131593413 PDLIM4 -0.4 -6.49 -0.34 3.24e-10 Breast cancer; CRC cis rs58688157 0.705 rs12419694 chr11:598033 C/T cg02461776 chr11:598696 PHRF1 0.47 6.09 0.32 3.11e-9 Systemic lupus erythematosus; CRC cis rs853679 0.760 rs9357067 chr6:28210293 C/G cg03623178 chr6:28175578 NA 0.74 7.82 0.4 7.43e-14 Depression; CRC cis rs11628318 0.570 rs2896450 chr14:103076595 T/C cg23071808 chr14:103021642 NA -0.64 -7.26 -0.37 2.86e-12 Platelet count; CRC cis rs12545109 0.879 rs2609994 chr8:57365844 A/G cg09654669 chr8:57350985 NA -0.44 -5.86 -0.31 1.12e-8 Obesity-related traits; CRC cis rs9322193 0.923 rs57938011 chr6:149964105 T/A cg00933542 chr6:150070202 PCMT1 0.32 6.36 0.33 6.8e-10 Lung cancer; CRC cis rs910316 0.763 rs175435 chr14:75612025 A/G cg03030879 chr14:75389066 RPS6KL1 -0.37 -5.67 -0.3 3.17e-8 Height; CRC cis rs73206853 0.534 rs7131996 chr12:111073276 C/A cg12870014 chr12:110450643 ANKRD13A 0.76 9.35 0.46 1.35e-18 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg05398773 chr8:71581521 XKR9;LACTB2 0.38 6.43 0.33 4.54e-10 Liver disease severity in Alagille syndrome; CRC cis rs2952156 0.684 rs931992 chr17:37821435 G/T cg00129232 chr17:37814104 STARD3 -0.71 -12.68 -0.57 2.77e-30 Asthma; CRC cis rs875971 0.571 rs160647 chr7:65554352 C/T cg03233332 chr7:66118400 NA 0.45 6.18 0.32 1.93e-9 Aortic root size; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg03771385 chr2:43454876 ZFP36L2;LOC100129726 0.38 6.1 0.32 2.98e-9 Liver disease severity in Alagille syndrome; CRC cis rs1005277 0.505 rs7069702 chr10:38247359 G/T cg00409905 chr10:38381863 ZNF37A 0.64 10.59 0.5 9.75e-23 Extrinsic epigenetic age acceleration; CRC cis rs12620999 1.000 rs13004252 chr2:238035408 C/A cg23555395 chr2:238036564 NA -0.62 -8.63 -0.43 2.61e-16 Systemic lupus erythematosus; CRC cis rs10504229 0.906 rs67389108 chr8:58193718 G/A cg05313129 chr8:58192883 C8orf71 -0.46 -7.13 -0.37 6.49e-12 Developmental language disorder (linguistic errors); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg24761882 chr9:96214934 FAM120AOS;FAM120A 0.43 5.99 0.31 5.63e-9 Response to antipsychotic treatment; CRC cis rs6938 0.534 rs8025447 chr15:75192222 T/G cg09165964 chr15:75287851 SCAMP5 0.57 9.15 0.45 5.96e-18 Breast cancer; CRC cis rs7666738 0.716 rs6827474 chr4:99089683 T/G cg05340658 chr4:99064831 C4orf37 0.51 7.48 0.38 6.73e-13 Colonoscopy-negative controls vs population controls; CRC cis rs9611565 0.729 rs2413646 chr22:41906325 C/T cg06634786 chr22:41940651 POLR3H -0.67 -7.67 -0.39 1.94e-13 Vitiligo; CRC cis rs3849570 1.000 rs3772882 chr3:81808602 C/A cg07356753 chr3:81810745 GBE1 -0.62 -8.9 -0.44 3.69e-17 Waist circumference;Body mass index; CRC cis rs2857891 0.909 rs56026267 chr11:6940211 T/C cg04053776 chr11:6947353 ZNF215 0.51 6.84 0.35 3.86e-11 Response to cytadine analogues (cytosine arabinoside); CRC cis rs992157 0.798 rs7587220 chr2:219160864 C/A cg00012203 chr2:219082015 ARPC2 -0.49 -7.29 -0.37 2.28e-12 Colorectal cancer; CRC cis rs738321 0.701 rs2413506 chr22:38593128 T/C cg25457927 chr22:38595422 NA -0.44 -8.06 -0.41 1.38e-14 Breast cancer; CRC cis rs2075371 0.611 rs35428392 chr7:134019645 G/A cg20476274 chr7:133979776 SLC35B4 0.54 7.57 0.38 3.89e-13 Mean platelet volume; CRC trans rs8073060 0.614 rs225279 chr17:33974214 A/G cg19694781 chr19:47549865 TMEM160 -1.05 -14.75 -0.63 3.75e-38 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; CRC cis rs2249694 0.520 rs11815623 chr10:135329133 A/G cg20169779 chr10:135381914 SYCE1 -0.55 -7.68 -0.39 1.85e-13 Obesity-related traits; CRC cis rs780094 0.500 rs7577311 chr2:27793921 G/T cg27432699 chr2:27873401 GPN1 0.45 5.84 0.31 1.22e-8 Calcium levels;Fasting blood insulin;Metabolic traits;Triglyceride levels;Fasting plasma glucose;Urate levels in overweight individuals;Urate levels in obese individuals;Uric acid levels;Height;Age-related diseases, mortality and associated endophenotypes;Renal underexcretion gout;Fasting blood glucose (BMI interaction);Urate levels;Gondoic acid (20:1n-9) levels;Fasting blood insulin (BMI interaction);Triglycerides;Plasma omega-3 polyunsaturated fatty acid levels (docosapentaenoic acid);Type 2 diabetes;Nonalcoholic fatty liver disease;Hypertriglyceridemia;C-reactive protein;Age-related disease endophenotypes;LDL cholesterol;Metabolic syndrome;Crohn's disease;Alcohol consumption (drinks per week);Homeostasis model assessment of insulin resistance;Alcohol consumption;Red blood cell count;Fasting blood glucose; CRC cis rs10979 1.000 rs9403505 chr6:143885841 A/G cg25407410 chr6:143891975 LOC285740 -0.76 -12.04 -0.55 6.44e-28 Hypospadias; CRC cis rs6922632 0.867 rs62400306 chr6:24111980 A/C cg26194775 chr6:24126114 NRSN1 -0.78 -7.93 -0.4 3.38e-14 Information processing speed; CRC cis rs10982256 0.875 rs11787667 chr9:117242845 C/T cg13636371 chr9:117264095 DFNB31 0.33 6.09 0.32 3.19e-9 Bipolar disorder; CRC cis rs1451375 0.583 rs7776816 chr7:50583534 G/A cg14593290 chr7:50529359 DDC 0.64 8.51 0.42 6.2e-16 Malaria; CRC cis rs12048904 0.505 rs11166511 chr1:101240686 G/C cg16556008 chr1:101360663 SLC30A7;EXTL2 -0.85 -13.17 -0.59 4.08e-32 Multiple sclerosis; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg01255913 chr5:176074484 TSPAN17 0.37 5.99 0.31 5.63e-9 Liver disease severity in Alagille syndrome; CRC cis rs8141529 0.719 rs2097461 chr22:29191879 T/C cg02153584 chr22:29168773 CCDC117 0.53 7.96 0.4 2.76e-14 Lymphocyte counts; CRC cis rs2032447 0.670 rs198834 chr6:26114372 G/A cg04800585 chr6:26043546 HIST1H2BB -0.41 -5.9 -0.31 9.1e-9 Intelligence (multi-trait analysis); CRC trans rs2464469 0.654 rs4646570 chr15:58343146 G/C cg18064655 chr19:3985414 EEF2 0.41 5.99 0.31 5.43e-9 Barrett's esophagus or Esophageal adenocarcinoma; CRC cis rs6465657 0.903 rs11767962 chr7:97778576 C/T cg00277769 chr7:97922759 BAIAP2L1 -0.4 -6.62 -0.34 1.42e-10 Prostate cancer (SNP x SNP interaction);Prostate cancer; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg10387458 chr1:93645817 TMED5;CCDC18 0.41 6.59 0.34 1.72e-10 Liver disease severity in Alagille syndrome; CRC cis rs7618915 0.547 rs4687638 chr3:52651966 A/C cg07507251 chr3:52567010 NT5DC2 0.46 6.68 0.35 1.01e-10 Bipolar disorder; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg01788360 chr4:56212215 SRD5A3 0.42 6.3 0.33 9.63e-10 Liver disease severity in Alagille syndrome; CRC cis rs597539 0.690 rs7129960 chr11:68622456 A/G cg06112835 chr11:68658793 MRPL21 0.45 6.91 0.36 2.46e-11 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs9309473 0.607 rs7586361 chr2:73601606 G/A cg20560298 chr2:73613845 ALMS1 -0.5 -7.02 -0.36 1.26e-11 Metabolite levels; CRC cis rs4332037 0.586 rs62442944 chr7:2015047 T/G cg25834613 chr7:1915315 MAD1L1 -0.47 -6.81 -0.35 4.71e-11 Bipolar disorder; CRC cis rs2576037 0.526 rs7240239 chr18:44460037 T/C cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.55 9.44 0.46 6.83e-19 Personality dimensions; CRC cis rs6912958 0.512 rs910563 chr6:88058885 G/A cg12350822 chr6:88032061 C6orf162;GJB7 0.44 9.07 0.45 1.14e-17 Monocyte percentage of white cells; CRC trans rs7615952 0.512 rs11929125 chr3:125359443 G/A cg08546805 chr12:8549446 NA -0.43 -6.55 -0.34 2.26e-10 Blood pressure (smoking interaction); CRC cis rs2239547 0.522 rs2336669 chr3:52994138 C/T cg10802521 chr3:52805072 NEK4 0.44 6.08 0.32 3.29e-9 Schizophrenia; CRC cis rs449789 0.857 rs592212 chr6:159711083 G/C cg14500486 chr6:159655392 FNDC1 -0.48 -7.4 -0.38 1.13e-12 Pulse pressure; CRC cis rs7605827 0.930 rs7575290 chr2:15597322 C/T cg19274914 chr2:15703543 NA 0.39 6.03 0.32 4.51e-9 Educational attainment (years of education); CRC cis rs10504229 1.000 rs56255635 chr8:58178264 T/C cg02725872 chr8:58115012 NA -0.38 -6.43 -0.33 4.44e-10 Developmental language disorder (linguistic errors); CRC cis rs425277 0.606 rs262653 chr1:2090095 T/G cg21194808 chr1:2205498 SKI 0.37 5.63 0.3 3.83e-8 Height; CRC cis rs9322193 0.923 rs6913486 chr6:150026196 C/T cg00933542 chr6:150070202 PCMT1 -0.32 -6.37 -0.33 6.48e-10 Lung cancer; CRC cis rs6604026 0.643 rs1360366 chr1:93330987 A/C cg17283838 chr1:93427260 FAM69A -0.48 -6.65 -0.34 1.19e-10 Multiple sclerosis; CRC cis rs10979 1.000 rs9399448 chr6:143896315 G/T cg25407410 chr6:143891975 LOC285740 -0.84 -13.84 -0.61 1.22e-34 Hypospadias; CRC cis rs1274963 0.601 rs784503 chr3:39197731 A/G cg02254461 chr3:39195904 CSRNP1 -0.54 -7.84 -0.4 6.41e-14 Chronic lymphocytic leukemia; CRC cis rs4664308 0.905 rs62175518 chr2:160915149 C/T cg03641300 chr2:160917029 PLA2R1 -0.69 -11.16 -0.52 1.01e-24 Idiopathic membranous nephropathy; CRC cis rs514406 0.627 rs485128 chr1:53344583 T/C cg08859206 chr1:53392774 SCP2 -0.61 -9.87 -0.48 2.67e-20 Monocyte count; CRC cis rs7843479 0.544 rs7839925 chr8:21792983 G/C cg16476235 chr8:21771668 DOK2 0.37 6.25 0.33 1.28e-9 Mean corpuscular volume; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg19777900 chr20:56284917 PMEPA1 0.46 6.54 0.34 2.34e-10 Anxiety disorder; CRC cis rs9443645 0.527 rs1413968 chr6:79791042 A/G cg05283184 chr6:79620031 NA -0.45 -6.5 -0.34 2.99e-10 Intelligence (multi-trait analysis); CRC cis rs4555082 0.874 rs3000075 chr14:105713219 C/T cg06808227 chr14:105710500 BRF1 0.63 9.42 0.46 8.07e-19 Mean platelet volume;Platelet distribution width; CRC cis rs6957923 0.818 rs12538407 chr7:23521316 A/G cg20265043 chr7:23510089 IGF2BP3 0.37 5.67 0.3 3.05e-8 Height; CRC cis rs2836974 1.000 rs28360661 chr21:40681972 G/C cg17971929 chr21:40555470 PSMG1 0.7 9.47 0.46 5.81e-19 Cognitive function; CRC cis rs798554 0.757 rs2644312 chr7:2841164 G/A cg14895029 chr7:2775587 GNA12 -0.44 -6.52 -0.34 2.67e-10 Height; CRC trans rs3733585 0.624 rs58130873 chr4:9972081 T/C cg26043149 chr18:55253948 FECH -0.49 -7.47 -0.38 7.26e-13 Cleft plate (environmental tobacco smoke interaction); CRC cis rs10751667 0.961 rs7395303 chr11:986221 T/A cg23136738 chr11:925521 AP2A2 -0.51 -8.23 -0.41 4.51e-15 Alzheimer's disease (late onset); CRC cis rs8177253 0.507 rs4241357 chr3:133475563 A/C cg01448562 chr3:133502909 NA 0.4 6.69 0.35 9.78e-11 Iron status biomarkers; CRC cis rs4819052 0.808 rs2838825 chr21:46655651 C/T cg02159808 chr21:46707872 POFUT2;LOC642852 0.47 5.92 0.31 8.07e-9 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs3790645 1.000 rs3790645 chr1:26884864 G/A cg23229016 chr1:26872525 RPS6KA1 0.3 7.14 0.37 6.2e-12 Glucose homeostasis traits; CRC cis rs514406 0.679 rs960570 chr1:53237763 A/G cg08859206 chr1:53392774 SCP2 0.63 10.08 0.49 5.32e-21 Monocyte count; CRC trans rs4942242 0.663 rs9525817 chr13:44225189 C/T cg19169023 chr15:41853346 TYRO3 0.61 8.25 0.41 3.75e-15 Response to tocilizumab in rheumatoid arthritis; CRC cis rs6681460 0.934 rs4655631 chr1:67054907 C/G cg02459107 chr1:67143332 SGIP1 0.49 8.49 0.42 7.32e-16 Presence of antiphospholipid antibodies; CRC cis rs7274811 0.901 rs17404047 chr20:32305781 A/T cg07470512 chr20:32255052 NECAB3;C20orf134 -0.5 -6.2 -0.32 1.65e-9 Height; CRC cis rs6502050 0.765 rs55905076 chr17:80105441 G/A cg13198984 chr17:80129470 CCDC57 0.47 8.26 0.41 3.61e-15 Life satisfaction; CRC cis rs7772486 0.817 rs12198065 chr6:146385286 G/C cg13319975 chr6:146136371 FBXO30 -0.39 -5.97 -0.31 6.13e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs910316 1.000 rs7147118 chr14:75610170 G/C cg11812906 chr14:75593930 NEK9 0.64 10.29 0.49 1.01e-21 Height; CRC trans rs2303319 0.504 rs62189046 chr2:162612371 C/G cg11326919 chr17:43324904 LOC100133991 -0.64 -5.97 -0.31 5.99e-9 Cognitive function; CRC cis rs7527798 0.592 rs1323720 chr1:207823161 T/C cg21110645 chr1:207815933 NA -0.4 -6.36 -0.33 6.93e-10 Erythrocyte sedimentation rate; CRC cis rs7726839 0.540 rs72703087 chr5:598029 C/T cg14541582 chr5:601475 NA -0.37 -7.38 -0.38 1.27e-12 Obesity-related traits; CRC cis rs11997175 1.000 rs10453046 chr8:33773179 T/C ch.8.33884649F chr8:33765107 NA 0.47 7.02 0.36 1.26e-11 Body mass index; CRC cis rs9443645 0.901 rs9443632 chr6:79664440 T/C cg05283184 chr6:79620031 NA -0.58 -9.17 -0.45 5.11e-18 Intelligence (multi-trait analysis); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg05134775 chr10:98273510 TLL2 0.41 6.91 0.36 2.54e-11 Liver disease severity in Alagille syndrome; CRC cis rs2204008 0.627 rs10878486 chr12:38148601 T/G cg26384229 chr12:38710491 ALG10B 0.71 9.43 0.46 7.56e-19 Bladder cancer; CRC cis rs933688 1.000 rs10073657 chr5:90689749 G/A cg02339078 chr5:90679543 LOC100129716;ARRDC3 0.92 15.49 0.65 5.13e-41 Smoking behavior; CRC cis rs3806843 0.966 rs2337516 chr5:140140853 A/G cg16607685 chr5:140181889 PCDHA2;PCDHA1;PCDHA3 0.28 6.5 0.34 3.03e-10 Depressive symptoms (multi-trait analysis); CRC cis rs9916302 0.904 rs2024073 chr17:37471330 T/G cg03013999 chr17:37608204 MED1 -0.48 -7.42 -0.38 1.02e-12 Glomerular filtration rate (creatinine); CRC cis rs11622475 1.000 rs56060232 chr14:104386165 G/C cg20488157 chr14:104394430 TDRD9 0.69 9.81 0.48 4.28e-20 Bipolar disorder; CRC cis rs6964587 0.967 rs4626516 chr7:91807153 G/C cg17063962 chr7:91808500 NA 0.78 12.42 0.56 2.62e-29 Breast cancer; CRC cis rs780096 0.526 rs11127013 chr2:27692973 A/G cg12648201 chr2:27665141 KRTCAP3 -0.32 -6.09 -0.32 3.23e-9 Total body bone mineral density; CRC cis rs11098499 0.909 rs79026312 chr4:120440677 C/A cg09307838 chr4:120376055 NA 0.68 10.32 0.49 8.22e-22 Corneal astigmatism; CRC cis rs11711311 0.736 rs13320940 chr3:113400954 G/T cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.48 -6.48 -0.34 3.43e-10 IgG glycosylation; CRC cis rs2976388 0.609 rs1469811 chr8:143787999 C/T cg22687807 chr8:143858763 LYNX1 0.51 9.15 0.45 6.04e-18 Urinary tract infection frequency; CRC cis rs2857891 0.909 rs56372435 chr11:6938658 T/C cg12728517 chr11:6947552 ZNF215 0.55 5.81 0.31 1.48e-8 Response to cytadine analogues (cytosine arabinoside); CRC cis rs4713118 0.666 rs4140646 chr6:27738801 G/A cg02683197 chr6:28174875 NA 0.68 7.33 0.37 1.81e-12 Parkinson's disease; CRC trans rs1814175 0.817 rs1988416 chr11:49932324 G/A cg21153622 chr11:89784906 NA -0.37 -5.99 -0.31 5.61e-9 Height; CRC trans rs66573146 0.656 rs41410847 chr4:6957332 C/T cg07817883 chr1:32538562 TMEM39B 1.05 11.5 0.54 5.91e-26 Granulocyte percentage of myeloid white cells; CRC cis rs2727020 0.521 rs2088526 chr11:49531968 G/A cg25886479 chr11:50257625 LOC441601 0.34 5.6 0.3 4.46e-8 Coronary artery disease; CRC cis rs892961 0.899 rs72896162 chr17:75412521 A/G cg05865280 chr17:75406074 SEPT9 0.63 14.51 0.62 3.27e-37 Airflow obstruction; CRC cis rs72781680 0.898 rs72786270 chr2:24059049 G/A cg08917208 chr2:24149416 ATAD2B 0.9 8.79 0.44 8.64e-17 Lymphocyte counts; CRC cis rs853679 0.517 rs9348794 chr6:28117757 T/A cg15786705 chr6:28176104 NA 0.78 9.83 0.48 3.57e-20 Depression; CRC cis rs2303745 0.589 rs751599 chr19:17396549 A/G cg04248312 chr19:17393744 ANKLE1 -0.93 -14.4 -0.62 8.79e-37 Systemic lupus erythematosus; CRC cis rs798554 0.704 rs709282 chr7:2769921 G/A cg17321639 chr7:2759063 NA -0.38 -5.68 -0.3 3.04e-8 Height; CRC cis rs780096 0.546 rs7563162 chr2:27631191 C/T cg22903471 chr2:27725779 GCKR -0.38 -6.27 -0.33 1.13e-9 Total body bone mineral density; CRC cis rs3806843 1.000 rs10066278 chr5:140156318 A/C cg19875535 chr5:140030758 IK 0.62 10.15 0.49 3.01e-21 Depressive symptoms (multi-trait analysis); CRC cis rs11123610 0.520 rs59726279 chr2:3718655 A/G cg19052272 chr2:3704530 ALLC -0.62 -7.69 -0.39 1.68e-13 Response to inhaled corticosteroid treatment in asthma (change in FEV1); CRC cis rs7647973 0.560 rs7638154 chr3:49299375 C/A cg07636037 chr3:49044803 WDR6 0.84 12.78 0.58 1.18e-30 Menarche (age at onset); CRC cis rs6860806 0.661 rs28472559 chr5:131581611 G/A cg12564285 chr5:131593104 PDLIM4 0.46 8.95 0.44 2.63e-17 Breast cancer; CRC cis rs9399137 0.507 rs6904897 chr6:135382980 T/G cg24558204 chr6:135376177 HBS1L 0.61 9.04 0.45 1.33e-17 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; CRC cis rs1707322 0.685 rs11211177 chr1:46226349 A/G cg06784218 chr1:46089804 CCDC17 0.64 11.72 0.54 9.78e-27 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs7937682 0.632 rs4936834 chr11:111764017 T/A cg09085632 chr11:111637200 PPP2R1B 0.95 15.13 0.64 1.25e-39 Primary sclerosing cholangitis; CRC cis rs11098499 0.954 rs56270433 chr4:120406030 C/T cg24375607 chr4:120327624 NA 0.5 7.71 0.39 1.49e-13 Corneal astigmatism; CRC cis rs7647973 1.000 rs6446262 chr3:49401153 T/C cg07690219 chr3:49449608 TCTA;RHOA -0.52 -5.71 -0.3 2.5e-8 Menarche (age at onset); CRC cis rs4964805 1.000 rs11111789 chr12:104191540 G/C cg02344784 chr12:104178138 NT5DC3 0.56 8.45 0.42 9.23e-16 Attention deficit hyperactivity disorder; CRC cis rs6951245 0.938 rs78351779 chr7:1097023 G/C cg04025307 chr7:1156635 C7orf50 0.63 6.74 0.35 7.02e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs9311474 0.629 rs7639267 chr3:52568805 G/T cg05573699 chr3:52720067 GNL3;PBRM1 -0.44 -6.65 -0.34 1.23e-10 Electroencephalogram traits; CRC cis rs561341 1.000 rs72825712 chr17:30316119 A/T cg12193833 chr17:30244370 NA -0.75 -8.8 -0.44 7.62e-17 Hip circumference adjusted for BMI; CRC cis rs1539053 0.966 rs1524707 chr1:58102540 A/G cg20292791 chr1:58089357 DAB1 0.34 6.03 0.32 4.35e-9 Plasma omega-6 polyunsaturated fatty acid levels (arachidonic acid); CRC cis rs10512697 0.541 rs62336074 chr5:3513171 G/A cg19473799 chr5:3511975 NA -0.83 -6.34 -0.33 7.66e-10 Immune response to smallpox vaccine (IL-6); CRC cis rs7103648 1.000 rs11039225 chr11:47430599 G/A cg20307385 chr11:47447363 PSMC3 1.0 18.38 0.71 2.11e-52 Diastolic blood pressure;Systolic blood pressure; CRC cis rs6585424 1.000 rs6585454 chr10:81940701 C/T cg11900509 chr10:81946545 ANXA11 0.73 9.04 0.45 1.38e-17 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs8060686 0.920 rs73594581 chr16:67955554 G/A cg26727032 chr16:67993705 SLC12A4 -0.57 -6.67 -0.35 1.08e-10 HDL cholesterol;Metabolic syndrome; CRC cis rs908922 0.676 rs4845443 chr1:152507156 C/T cg09873164 chr1:152488093 CRCT1 0.39 6.53 0.34 2.51e-10 Hair morphology; CRC cis rs977987 0.806 rs12933281 chr16:75483064 T/G cg03315344 chr16:75512273 CHST6 0.57 9.74 0.47 7.35e-20 Dupuytren's disease; CRC cis rs2839186 0.771 rs13049175 chr21:47641326 G/A cg08742575 chr21:47604166 C21orf56 -0.37 -5.73 -0.3 2.27e-8 Testicular germ cell tumor; CRC cis rs2239547 0.603 rs17304995 chr3:53070755 A/G cg18404041 chr3:52824283 ITIH1 -0.36 -6.18 -0.32 1.91e-9 Schizophrenia; CRC cis rs28386778 0.897 rs968719 chr17:61908271 C/T cg25654072 chr17:61904446 PSMC5;FTSJ3 0.74 10.84 0.51 1.28e-23 Prudent dietary pattern; CRC cis rs3733585 0.699 rs12498956 chr4:9950705 G/T cg00071950 chr4:10020882 SLC2A9 -0.54 -9.64 -0.47 1.53e-19 Cleft plate (environmental tobacco smoke interaction); CRC cis rs9648716 1.000 rs10281173 chr7:140579876 A/G cg10747023 chr7:140774559 NA -0.43 -5.83 -0.31 1.31e-8 Type 2 diabetes; CRC cis rs933688 0.941 rs6452954 chr5:90735692 G/A cg02339078 chr5:90679543 LOC100129716;ARRDC3 0.85 14.63 0.63 1.06e-37 Smoking behavior; CRC trans rs916888 0.738 rs199515 chr17:44856641 C/G cg22968622 chr17:43663579 NA -1.16 -15.24 -0.64 4.8e-40 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs1707322 0.721 rs11211157 chr1:46132844 T/C cg03146154 chr1:46216737 IPP 0.67 9.75 0.47 6.98e-20 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs7811142 1.000 rs11771241 chr7:99994785 G/A cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.98 13.02 0.58 1.58e-31 Platelet count; CRC cis rs72781680 0.898 rs72798064 chr2:23982832 T/C cg08917208 chr2:24149416 ATAD2B 0.86 8.45 0.42 9.66e-16 Lymphocyte counts; CRC cis rs2404602 0.647 rs11072636 chr15:77185786 A/G cg03037974 chr15:76606532 NA -0.55 -8.22 -0.41 4.68e-15 Blood metabolite levels; CRC cis rs875971 1.000 rs709597 chr7:65825983 A/G cg12463550 chr7:65579703 CRCP -0.43 -6.09 -0.32 3.11e-9 Aortic root size; CRC cis rs1580019 0.563 rs34319173 chr7:32585904 G/A cg07520158 chr7:32535189 LSM5;AVL9 0.53 7.66 0.39 2.04e-13 Cognitive ability; CRC cis rs4664293 0.625 rs7595852 chr2:160540167 G/C cg08347373 chr2:160653686 CD302 0.39 6.53 0.34 2.55e-10 Monocyte percentage of white cells; CRC cis rs116095464 0.558 rs10052012 chr5:231908 T/C cg22496380 chr5:211416 CCDC127 -0.88 -10.28 -0.49 1.1e-21 Breast cancer; CRC cis rs896854 0.654 rs896847 chr8:95972551 G/A cg09323728 chr8:95962352 TP53INP1 -0.45 -7.46 -0.38 7.88e-13 Type 2 diabetes; CRC trans rs4927850 1.000 rs10881563 chr3:195750225 A/G cg16724585 chr3:197361211 NA -0.54 -7.83 -0.4 6.67e-14 Pancreatic cancer; CRC cis rs75422866 0.867 rs73104115 chr12:48078626 C/T cg14736327 chr12:48174669 SLC48A1 -0.79 -6.01 -0.31 4.92e-9 Pneumonia; CRC cis rs7927592 0.913 rs6591346 chr11:68384618 T/A cg01657329 chr11:68192670 LRP5 -0.5 -7.74 -0.39 1.24e-13 Total body bone mineral density; CRC cis rs9443645 0.901 rs1027813 chr6:79552118 G/T cg11833968 chr6:79620685 NA 0.34 6.04 0.32 4.18e-9 Intelligence (multi-trait analysis); CRC cis rs72615157 0.561 rs113844570 chr7:99873778 A/C cg13153964 chr7:100026424 MEPCE;ZCWPW1 0.81 9.37 0.46 1.22e-18 Lung function (FEV1/FVC); CRC cis rs6120849 0.617 rs12480442 chr20:33648388 C/G cg08999081 chr20:33150536 PIGU 0.45 5.79 0.3 1.69e-8 Protein C levels; CRC cis rs2120019 1.000 rs1867146 chr15:75354971 C/G cg09165964 chr15:75287851 SCAMP5 -0.85 -12.9 -0.58 4.25e-31 Blood trace element (Zn levels); CRC cis rs10504229 0.593 rs78459635 chr8:58004995 G/T cg11062466 chr8:58055876 NA 0.54 6.63 0.34 1.35e-10 Developmental language disorder (linguistic errors); CRC cis rs8180040 0.587 rs1466741 chr3:47247214 C/T cg10298567 chr3:47292165 KIF9 0.4 6.25 0.33 1.24e-9 Colorectal cancer; CRC cis rs13191362 0.935 rs7767254 chr6:162954674 T/G cg06582575 chr6:163149167 PACRG;PARK2 0.81 10.09 0.49 4.95e-21 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs7945705 0.791 rs7944560 chr11:8817276 A/T cg21881798 chr11:8931708 C11orf17;ST5 0.53 8.17 0.41 6.58e-15 Hemoglobin concentration; CRC trans rs2303319 0.504 rs12467613 chr2:162603216 G/T cg11326919 chr17:43324904 LOC100133991 -0.64 -5.97 -0.31 5.99e-9 Cognitive function; CRC cis rs2380220 0.720 rs9400397 chr6:95980623 C/A cg04719120 chr6:96025338 MANEA 0.55 6.47 0.34 3.47e-10 Behavioural disinhibition (generation interaction); CRC cis rs6088580 0.634 rs6059887 chr20:33101102 C/G cg08999081 chr20:33150536 PIGU 0.63 11.63 0.54 1.96e-26 Glomerular filtration rate (creatinine); CRC cis rs7615952 0.576 rs2276726 chr3:125826287 C/G cg18479299 chr3:125709523 NA -0.47 -5.96 -0.31 6.4e-9 Blood pressure (smoking interaction); CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg13937449 chr12:56320970 WIBG 0.47 6.13 0.32 2.5e-9 Thyroid stimulating hormone; CRC cis rs12908161 1.000 rs11638290 chr15:85227636 C/T cg17507749 chr15:85114479 UBE2QP1 0.63 8.93 0.44 2.99e-17 Schizophrenia; CRC cis rs2153535 0.580 rs962590 chr6:8450899 A/G cg21535247 chr6:8435926 SLC35B3 0.5 7.45 0.38 8.15e-13 Motion sickness; CRC cis rs9399135 0.507 rs2072825 chr6:135253451 A/G cg24558204 chr6:135376177 HBS1L -0.54 -7.86 -0.4 5.72e-14 Red blood cell count; CRC trans rs1973993 0.691 rs6658131 chr1:96889314 C/T cg10631902 chr5:14652156 NA 0.59 11.72 0.54 9.45e-27 Weight; CRC cis rs798554 0.959 rs798557 chr7:2758982 G/A cg14863265 chr7:2801509 GNA12 -0.42 -5.85 -0.31 1.16e-8 Height; CRC cis rs12024301 0.557 rs12029926 chr1:183640149 C/T cg11505048 chr1:183622726 RGL1;APOBEC4 -0.78 -7.04 -0.36 1.12e-11 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs6951245 0.638 rs74976697 chr7:1160505 C/T cg24642844 chr7:1081250 C7orf50 -0.68 -8.63 -0.43 2.61e-16 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs9914988 0.943 rs9898892 chr17:27150750 T/C cg07195577 chr17:27052828 TLCD1 0.41 5.92 0.31 7.89e-9 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs1499614 1.000 rs2141924 chr7:66186246 C/T cg18252515 chr7:66147081 NA -1.24 -14.45 -0.62 5.42e-37 Gout; CRC cis rs2797160 0.935 rs6940748 chr6:125994080 C/T cg05901451 chr6:126070800 HEY2 -0.38 -5.83 -0.31 1.33e-8 Endometrial cancer; CRC cis rs9992667 0.955 rs9992076 chr4:38644667 C/T cg19726192 chr4:38663646 FLJ13197 -0.66 -8.73 -0.43 1.31e-16 Eosinophil percentage of granulocytes; CRC cis rs4665809 1.000 rs4665309 chr2:26335502 T/C cg22920501 chr2:26401640 FAM59B -0.52 -7.15 -0.37 5.68e-12 Gut microbiome composition (summer); CRC cis rs6908034 0.660 rs111509549 chr6:19798370 A/G cg02682789 chr6:19804855 NA 0.81 6.89 0.35 2.9100000000000002e-11 Endometriosis;Deep ovarian and/or rectovaginal disease with dense adhesions; CRC cis rs7726839 0.561 rs72703058 chr5:584519 G/A cg14541582 chr5:601475 NA -0.32 -6.65 -0.34 1.2e-10 Obesity-related traits; CRC cis rs875971 0.862 rs6944374 chr7:65686929 C/G cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.41 -5.62 -0.3 4.17e-8 Aortic root size; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg23229228 chr3:98312354 CPOX 0.45 6.34 0.33 7.43e-10 Response to antipsychotic treatment; CRC cis rs7726839 0.540 rs4957081 chr5:646418 G/C cg16447950 chr5:562315 NA -0.77 -10.22 -0.49 1.75e-21 Obesity-related traits; CRC cis rs375066 0.623 rs1549954 chr19:44348805 C/A cg19542119 chr19:44331823 ZNF283 0.4 5.61 0.3 4.3e-8 Breast cancer; CRC cis rs7224737 0.956 rs8081900 chr17:40289875 G/A cg20291162 chr17:40259547 DHX58 -0.55 -8.0 -0.4 2.16e-14 Fibrinogen levels; CRC cis rs7552404 0.765 rs1251078 chr1:76189488 C/G cg10523679 chr1:76189770 ACADM -0.92 -16.5 -0.67 5.67e-45 Blood metabolite levels;Acylcarnitine levels; CRC cis rs9549260 0.755 rs4943800 chr13:41216831 A/G cg21288729 chr13:41239152 FOXO1 0.49 7.66 0.39 2.08e-13 Red blood cell count; CRC cis rs11741688 0.631 rs4444956 chr5:178325515 A/G cg20935368 chr5:178288625 ZNF354B 0.45 7.0 0.36 1.42e-11 Sleep duration; CRC cis rs6502050 0.799 rs9911129 chr17:80087819 C/T cg13198984 chr17:80129470 CCDC57 0.47 8.45 0.42 9.24e-16 Life satisfaction; CRC cis rs8072100 0.790 rs34200664 chr17:45744652 C/T cg25173405 chr17:45401733 C17orf57 0.39 5.91 0.31 8.69e-9 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs4664308 0.840 rs17218566 chr2:161054748 C/T cg03641300 chr2:160917029 PLA2R1 -0.7 -11.99 -0.55 9.88e-28 Idiopathic membranous nephropathy; CRC cis rs6963495 0.818 rs75116202 chr7:105160059 C/T cg13798780 chr7:105162888 PUS7 0.68 8.08 0.41 1.27e-14 Bipolar disorder (body mass index interaction); CRC cis rs9549328 0.670 rs2873372 chr13:113613383 A/G cg25790453 chr13:113633590 MCF2L -0.45 -7.88 -0.4 4.69e-14 Systolic blood pressure; CRC cis rs11252926 0.574 rs4881313 chr10:487973 C/T cg03684893 chr10:554711 DIP2C 0.35 5.93 0.31 7.67e-9 Psychosis in Alzheimer's disease; CRC cis rs6700896 0.966 rs7542446 chr1:66091106 G/A cg04111102 chr1:66153794 NA 0.33 5.8 0.3 1.55e-8 C-reactive protein;Mean corpuscular volume;Mean corpuscular hemoglobin; CRC cis rs9372498 0.536 rs62424199 chr6:118827252 G/A cg24463073 chr6:118973353 C6orf204 0.52 6.97 0.36 1.78e-11 Diastolic blood pressure; CRC cis rs6570726 0.791 rs2096201 chr6:145934273 C/T cg05347473 chr6:146136440 FBXO30 0.38 5.8 0.3 1.58e-8 Lobe attachment (rater-scored or self-reported); CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg01101876 chr2:183580910 DNAJC10 -0.44 -6.98 -0.36 1.6e-11 Myopia (pathological); CRC cis rs62064224 0.714 rs4794915 chr17:30634363 A/G cg12855166 chr17:30846586 MYO1D 0.37 6.16 0.32 2.14e-9 Schizophrenia; CRC cis rs11190604 1.000 rs3750629 chr10:102275727 A/G cg16342193 chr10:102329863 NA -0.34 -5.69 -0.3 2.86e-8 Palmitoleic acid (16:1n-7) levels; CRC cis rs2204008 0.805 rs2874289 chr12:38258420 G/A cg26384229 chr12:38710491 ALG10B 0.69 9.22 0.45 3.69e-18 Bladder cancer; CRC cis rs7119 0.678 rs12914098 chr15:77823013 C/T cg10437265 chr15:77819839 NA 0.67 12.18 0.56 2.05e-28 Type 2 diabetes; CRC cis rs1552244 1.000 rs56270432 chr3:10087517 G/C cg18598329 chr3:10140678 FANCD2;C3orf24 -0.88 -12.26 -0.56 1.03e-28 Alzheimer's disease; CRC cis rs7811142 0.830 rs6948685 chr7:99970188 C/T cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.95 12.68 0.57 2.91e-30 Platelet count; CRC cis rs753778 0.570 rs6985866 chr8:142210336 C/T cg18755752 chr8:142205143 DENND3 0.6 10.16 0.49 2.77e-21 Reticulocyte fraction of red cells;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; CRC cis rs4478137 0.824 rs4691907 chr4:164223658 G/T cg06758707 chr4:164254230 NPY1R 0.47 7.16 0.37 5.38e-12 Subjective well-being (multi-trait analysis);Subjective well-being; CRC cis rs2952156 0.959 rs2517956 chr17:37843859 G/A cg00129232 chr17:37814104 STARD3 -0.72 -12.14 -0.56 2.93e-28 Asthma; CRC trans rs916888 0.773 rs169201 chr17:44790203 A/G cg22968622 chr17:43663579 NA 1.4 17.21 0.69 8.73e-48 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs4888262 0.508 rs4887779 chr16:74647795 A/G cg01733217 chr16:74700730 RFWD3 -0.81 -12.48 -0.57 1.55e-29 Testicular germ cell tumor; CRC cis rs8180040 0.654 rs1466740 chr3:47245883 C/T cg27129171 chr3:47204927 SETD2 -0.71 -11.23 -0.53 5.27e-25 Colorectal cancer; CRC cis rs3806843 1.000 rs10073974 chr5:140165231 T/C cg16607685 chr5:140181889 PCDHA2;PCDHA1;PCDHA3 -0.26 -5.92 -0.31 8.06e-9 Depressive symptoms (multi-trait analysis); CRC cis rs10504229 1.000 rs17805549 chr8:58179653 T/C cg02725872 chr8:58115012 NA -0.38 -6.43 -0.33 4.44e-10 Developmental language disorder (linguistic errors); CRC trans rs208520 0.754 rs12204635 chr6:66740779 C/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 1.05 14.83 0.63 1.81e-38 Exhaled nitric oxide output; CRC cis rs6701037 0.714 rs2285219 chr1:175130983 A/T cg14847009 chr1:175162515 KIAA0040 -0.27 -5.87 -0.31 1.08e-8 Alcohol dependence; CRC cis rs1559088 0.600 rs6510344 chr19:33583942 C/A cg27124370 chr19:33622961 WDR88 0.48 6.93 0.36 2.16e-11 Bone ultrasound measurement (broadband ultrasound attenuation); CRC cis rs2361718 0.500 rs8064429 chr17:78096187 A/C cg20811857 chr17:78079795 GAA -0.52 -7.89 -0.4 4.39e-14 Yeast infection; CRC cis rs2228479 0.850 rs45567439 chr16:89814604 G/A cg06656553 chr16:89960601 TCF25 -0.69 -5.74 -0.3 2.15e-8 Skin colour saturation; CRC cis rs4862750 0.874 rs6822062 chr4:187895553 T/C cg11301795 chr4:187892539 NA -0.87 -19.89 -0.74 2.27e-58 Lobe attachment (rater-scored or self-reported); CRC cis rs853679 0.505 rs200992 chr6:27814677 A/G cg15845792 chr6:28175446 NA 0.72 5.83 0.31 1.29e-8 Depression; CRC cis rs10791097 0.720 rs6590517 chr11:130733505 C/T cg12179176 chr11:130786555 SNX19 0.72 11.32 0.53 2.61e-25 Autism spectrum disorder or schizophrenia;Schizophrenia; CRC cis rs1577917 0.771 rs9362230 chr6:86305013 G/A cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.67 -8.79 -0.44 8.78e-17 Response to antipsychotic treatment; CRC cis rs13118159 0.550 rs4974611 chr4:1358449 T/C cg05025164 chr4:1340916 KIAA1530 0.59 8.41 0.42 1.25e-15 Longevity; CRC cis rs6546550 1.000 rs6546550 chr2:70038232 C/G cg02498382 chr2:70120550 SNRNP27 -0.46 -7.61 -0.39 2.99e-13 Prevalent atrial fibrillation; CRC cis rs7147624 0.572 rs2411813 chr14:66023906 G/A cg03016385 chr14:66212404 NA -0.99 -8.84 -0.44 5.86e-17 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs2075371 1.000 rs2544213 chr7:133982867 G/C cg20476274 chr7:133979776 SLC35B4 0.82 15.16 0.64 1e-39 Mean platelet volume; CRC cis rs4713118 0.587 rs61471148 chr6:28037032 T/A cg06470822 chr6:28175283 NA 0.93 12.38 0.56 3.59e-29 Parkinson's disease; CRC trans rs11098499 0.754 rs7689729 chr4:120256192 A/G cg25214090 chr10:38739885 LOC399744 0.54 8.52 0.43 5.9e-16 Corneal astigmatism; CRC cis rs853679 0.517 rs9348797 chr6:28137533 G/C cg06470822 chr6:28175283 NA 1.03 13.59 0.6 1.04e-33 Depression; CRC cis rs67311347 0.577 rs1880763 chr3:40283255 C/T cg09455208 chr3:40491958 NA -0.35 -7.08 -0.36 8.78e-12 Renal cell carcinoma; CRC cis rs10504229 0.565 rs7010503 chr8:58147127 G/A cg22535103 chr8:58192502 C8orf71 -0.66 -9.49 -0.46 4.7e-19 Developmental language disorder (linguistic errors); CRC cis rs13191362 0.507 rs1954810 chr6:163061749 C/T cg06582575 chr6:163149167 PACRG;PARK2 -0.55 -8.68 -0.43 1.85e-16 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs9903692 0.738 rs35202025 chr17:46152717 A/G cg21215337 chr17:46176117 CBX1 0.42 7.79 0.39 8.7e-14 Pulse pressure; CRC cis rs2243480 1.000 rs781156 chr7:65479141 C/A cg12463550 chr7:65579703 CRCP 0.67 6.26 0.33 1.2e-9 Diabetic kidney disease; CRC cis rs9648716 1.000 rs7796827 chr7:140601843 C/T cg10747023 chr7:140774559 NA 0.45 5.9 0.31 9.21e-9 Type 2 diabetes; CRC cis rs9487051 0.646 rs7773490 chr6:109623048 T/C cg01475377 chr6:109611718 NA -0.36 -5.77 -0.3 1.86e-8 Reticulocyte fraction of red cells; CRC cis rs7085104 0.684 rs7092690 chr10:104609365 T/C cg04362960 chr10:104952993 NT5C2 0.59 8.68 0.43 1.92e-16 Immature fraction of reticulocytes;Schizophrenia; CRC cis rs1448094 0.817 rs61929421 chr12:86342330 T/C cg18827107 chr12:86230957 RASSF9 -0.42 -6.71 -0.35 8.57e-11 Major depressive disorder; CRC cis rs1046896 0.553 rs56775875 chr17:80831291 G/T cg17346650 chr17:80929145 B3GNTL1 0.48 7.06 0.36 1.02e-11 Glycated hemoglobin levels; CRC cis rs7552404 1.000 rs7513559 chr1:76173744 A/G cg03433033 chr1:76189801 ACADM 0.81 11.3 0.53 3.09e-25 Blood metabolite levels;Acylcarnitine levels; CRC trans rs6951245 1.000 rs79617366 chr7:1111958 G/C cg13565492 chr6:43139072 SRF -0.72 -7.43 -0.38 9.33e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs9916302 0.706 rs9646419 chr17:37597185 A/G cg15445000 chr17:37608096 MED1 0.36 6.27 0.33 1.14e-9 Glomerular filtration rate (creatinine); CRC cis rs2033711 0.870 rs7409473 chr19:58939165 A/G cg13877915 chr19:58951672 ZNF132 0.52 8.66 0.43 2.11e-16 Uric acid clearance; CRC cis rs10504229 0.645 rs56670121 chr8:58138872 C/T cg02725872 chr8:58115012 NA -0.64 -11.51 -0.54 5.63e-26 Developmental language disorder (linguistic errors); CRC cis rs5750830 0.649 rs5750813 chr22:39795228 G/C cg11247378 chr22:39784982 NA -0.44 -8.03 -0.4 1.74e-14 Intelligence (multi-trait analysis); CRC cis rs12476592 0.602 rs6736411 chr2:63674060 G/A cg10828910 chr2:63850056 LOC388955 0.47 5.94 0.31 7.39e-9 Childhood ear infection; CRC cis rs10256972 0.553 rs4236381 chr7:1165723 A/C cg04025307 chr7:1156635 C7orf50 0.79 13.03 0.58 1.43e-31 Longevity;Endometriosis; CRC cis rs2806561 0.754 rs10917344 chr1:23342193 C/G cg19743168 chr1:23544995 NA -0.4 -6.36 -0.33 6.59e-10 Height; CRC cis rs12142240 0.659 rs72677591 chr1:46818219 T/G cg00530320 chr1:46809349 NSUN4 0.58 8.01 0.4 1.95e-14 Menopause (age at onset); CRC cis rs1448094 0.511 rs4278581 chr12:86151054 A/G cg00310523 chr12:86230176 RASSF9 -0.36 -5.92 -0.31 8.25e-9 Major depressive disorder; CRC cis rs898097 0.585 rs9892342 chr17:80893029 C/T cg19046167 chr17:80928561 B3GNTL1 0.45 7.59 0.39 3.23e-13 Breast cancer; CRC trans rs2018683 0.834 rs733485 chr7:29026685 C/A cg19402173 chr7:128379420 CALU -0.53 -7.87 -0.4 5.33e-14 Response to irinotecan and platinum-based chemotherapy in non-small-cell lung cancer; CRC cis rs875971 0.502 rs1796227 chr7:66087019 G/C cg03233332 chr7:66118400 NA 0.43 5.92 0.31 7.98e-9 Aortic root size; CRC cis rs6912958 0.605 rs2754247 chr6:88383571 A/G cg12350822 chr6:88032061 C6orf162;GJB7 -0.35 -6.55 -0.34 2.25e-10 Monocyte percentage of white cells; CRC cis rs7429990 0.965 rs34507589 chr3:47874042 C/G cg11946769 chr3:48343235 NME6 0.57 6.54 0.34 2.32e-10 Educational attainment (years of education); CRC cis rs1552244 1.000 rs9809061 chr3:10085130 C/G cg10729496 chr3:10149963 C3orf24 0.5 6.78 0.35 5.69e-11 Alzheimer's disease; CRC cis rs6728642 0.519 rs6721921 chr2:97566501 G/A cg26665480 chr2:98280029 ACTR1B -0.54 -5.9 -0.31 9.2e-9 Bipolar disorder lithium response (continuous) or schizophrenia; CRC cis rs6502050 0.799 rs28376857 chr17:80104351 G/A cg22110888 chr17:80059540 CCDC57 0.4 6.44 0.33 4.17e-10 Life satisfaction; CRC cis rs10504229 1.000 rs61733801 chr8:58192513 A/G cg24829409 chr8:58192753 C8orf71 -0.68 -11.34 -0.53 2.27e-25 Developmental language disorder (linguistic errors); CRC cis rs2276314 0.553 rs4799842 chr18:33627968 C/A cg19628046 chr18:33552617 C18orf21 0.46 7.13 0.37 6.22e-12 Endometriosis;Drug-induced torsades de pointes; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg26778807 chr12:118498675 WSB2 0.41 6.33 0.33 8.17e-10 Intelligence (multi-trait analysis); CRC cis rs62244186 0.520 rs9311361 chr3:44796132 T/G cg10263370 chr3:44754102 ZNF502 -0.37 -6.37 -0.33 6.48e-10 Depressive symptoms; CRC cis rs17162190 0.698 rs4970498 chr1:26844195 G/A cg17456097 chr1:26900765 RPS6KA1 0.42 5.81 0.31 1.47e-8 Mean corpuscular volume; CRC cis rs1395 0.571 rs114507490 chr2:27527246 T/A cg23587288 chr2:27483067 SLC30A3 -0.4 -5.82 -0.31 1.42e-8 Blood metabolite levels; CRC cis rs10779751 0.770 rs12075896 chr1:11200350 C/A cg08854313 chr1:11322531 MTOR -0.58 -7.41 -0.38 1.07e-12 Body mass index; CRC cis rs34779708 0.966 rs4294520 chr10:35422506 C/T cg03585969 chr10:35415529 CREM 0.66 8.68 0.43 1.88e-16 Inflammatory bowel disease;Crohn's disease; CRC cis rs4481887 0.927 rs6666903 chr1:248465582 T/A cg00666640 chr1:248458726 OR2T12 0.46 8.02 0.4 1.87e-14 Common traits (Other); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg10317628 chr1:117113342 CD58 0.45 6.2 0.32 1.67e-9 Response to antipsychotic treatment; CRC cis rs394563 0.591 rs237016 chr6:149744859 T/C cg07828024 chr6:149772892 ZC3H12D -0.48 -9.04 -0.45 1.39e-17 Dupuytren's disease; CRC cis rs9322193 0.884 rs62439836 chr6:149990309 A/G cg00933542 chr6:150070202 PCMT1 0.3 6.06 0.32 3.71e-9 Lung cancer; CRC cis rs4862750 0.872 rs6553029 chr4:187876470 G/T cg03452623 chr4:187889614 NA 0.88 19.77 0.74 6.97e-58 Lobe attachment (rater-scored or self-reported); CRC cis rs4746818 1.000 rs7916991 chr10:70895373 C/A cg11621586 chr10:70884670 VPS26A 0.91 7.93 0.4 3.57e-14 Left atrial antero-posterior diameter; CRC cis rs4713118 0.629 rs172165 chr6:28020814 T/G cg15786705 chr6:28176104 NA 0.67 9.29 0.46 2.23e-18 Parkinson's disease; CRC cis rs7312933 0.567 rs11181399 chr12:42666412 G/A cg19980929 chr12:42632907 YAF2 0.48 7.35 0.38 1.62e-12 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CRC cis rs896854 0.540 rs2011567 chr8:95971920 G/A cg09323728 chr8:95962352 TP53INP1 -0.45 -7.46 -0.38 7.69e-13 Type 2 diabetes; CRC cis rs12477438 0.520 rs6712704 chr2:99719687 C/T cg26064155 chr2:99771622 LIPT1;TSGA10 0.88 16.24 0.67 5.52e-44 Chronic sinus infection; CRC trans rs1455244 0.700 rs7229302 chr18:11508904 G/T cg22468868 chr17:58042029 RNFT1 0.42 6.55 0.34 2.21e-10 Schizophrenia; CRC cis rs62458065 0.568 rs62463963 chr7:32486691 C/T cg20159608 chr7:32802032 NA -0.59 -7.37 -0.38 1.36e-12 Metabolite levels (HVA/MHPG ratio); CRC cis rs9322193 0.962 rs10452626 chr6:150088617 T/C cg05861140 chr6:150128134 PCMT1 -0.44 -7.18 -0.37 4.53e-12 Lung cancer; CRC cis rs17376456 0.825 rs10052662 chr5:93271385 A/G cg09848695 chr5:92956644 FAM172A;MIR2277 0.67 5.78 0.3 1.76e-8 Diabetic retinopathy; CRC cis rs6460942 0.597 rs17590609 chr7:12142411 A/C cg06484146 chr7:12443880 VWDE -0.52 -6.27 -0.33 1.11e-9 Coronary artery disease; CRC cis rs28386778 0.897 rs2584610 chr17:61934783 T/C cg23090583 chr17:61904693 PSMC5;FTSJ3 1.03 19.53 0.73 6.22e-57 Prudent dietary pattern; CRC cis rs6496667 0.779 rs8032687 chr15:90945186 C/T cg04176472 chr15:90893244 GABARAPL3 0.59 7.69 0.39 1.72e-13 Rheumatoid arthritis; CRC cis rs2976388 0.609 rs2585153 chr8:143785345 G/A cg04969067 chr8:143858791 LYNX1 0.45 7.54 0.38 4.72e-13 Urinary tract infection frequency; CRC cis rs1887596 0.705 rs9788361 chr13:27201814 A/G cg01312412 chr13:27282625 NA 0.45 5.75 0.3 2.01e-8 Facial morphology (factor 3, length of philtrum); CRC cis rs10540 1.000 rs61876326 chr11:467368 A/G cg03934478 chr11:495069 RNH1 0.66 7.41 0.38 1.1e-12 Body mass index; CRC cis rs17376456 0.825 rs13357713 chr5:93145423 T/C cg21475434 chr5:93447410 FAM172A 0.71 7.05 0.36 1.04e-11 Diabetic retinopathy; CRC cis rs6696846 0.703 rs112653854 chr1:205079251 G/T cg00857998 chr1:205179979 DSTYK 0.45 6.3 0.33 9.7e-10 Red blood cell count; CRC cis rs1832871 0.644 rs56180963 chr6:158773990 G/A cg07165851 chr6:158734300 TULP4 0.6 7.65 0.39 2.28e-13 Height; CRC cis rs60871478 1.000 rs4720930 chr7:808073 G/A cg04727924 chr7:799746 HEATR2 -0.45 -6.64 -0.34 1.3e-10 Cerebrospinal P-tau181p levels; CRC cis rs1448094 0.580 rs11615323 chr12:86282171 T/C cg18827107 chr12:86230957 RASSF9 -0.47 -7.17 -0.37 5.11e-12 Major depressive disorder; CRC cis rs950169 1.000 rs1818950 chr15:84722521 A/G cg03959625 chr15:84868606 LOC388152 0.42 6.25 0.33 1.24e-9 Schizophrenia; CRC trans rs459571 0.916 rs109536 chr9:136889987 G/C cg09836344 chr4:1243392 C4orf42;CTBP1 -0.77 -10.53 -0.5 1.5e-22 Platelet distribution width; CRC cis rs9486719 1.000 rs11756315 chr6:97008678 A/G cg06623918 chr6:96969491 KIAA0776 0.77 9.16 0.45 5.83e-18 Migraine;Coronary artery disease; CRC cis rs1113500 0.933 rs4517375 chr1:108638330 A/C cg06207961 chr1:108661230 NA -0.39 -5.7 -0.3 2.63e-8 Growth-regulated protein alpha levels; CRC cis rs7786808 0.741 rs7789415 chr7:158227617 C/T cg17401720 chr7:158221031 PTPRN2 0.49 8.14 0.41 8.44e-15 Obesity-related traits; CRC cis rs7666738 0.830 rs1593569 chr4:99017485 C/G cg05340658 chr4:99064831 C4orf37 0.58 8.89 0.44 4.26e-17 Colonoscopy-negative controls vs population controls; CRC cis rs6694672 1.000 rs4915148 chr1:197035538 C/T cg13682187 chr1:196946512 CFHR5 -0.47 -7.37 -0.38 1.38e-12 Asthma; CRC cis rs898097 0.812 rs56405605 chr17:80843663 T/C cg19046167 chr17:80928561 B3GNTL1 -0.42 -6.4 -0.33 5.25e-10 Breast cancer; CRC cis rs9467711 0.651 rs16891261 chr6:26062631 A/G cg08501292 chr6:25962987 TRIM38 0.89 8.35 0.42 1.87e-15 Autism spectrum disorder or schizophrenia; CRC cis rs116095464 0.558 rs28729548 chr5:229025 C/T cg22496380 chr5:211416 CCDC127 -0.86 -10.04 -0.48 7.52e-21 Breast cancer; CRC trans rs916888 0.610 rs199454 chr17:44800110 G/A cg22968622 chr17:43663579 NA -0.81 -11.31 -0.53 2.85e-25 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs7811142 0.887 rs35111986 chr7:100000274 C/A cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.74 9.67 0.47 1.25e-19 Platelet count; CRC cis rs4363385 0.510 rs1500937 chr1:153045483 G/C cg25856811 chr1:152973957 SPRR3 -0.21 -5.62 -0.3 4.03e-8 Inflammatory skin disease; CRC cis rs56114371 0.777 rs200482 chr6:27773904 G/A cg03623178 chr6:28175578 NA 0.78 6.94 0.36 2.07e-11 Breast cancer; CRC cis rs12477438 0.765 rs1453564 chr2:99564428 C/T cg26064155 chr2:99771622 LIPT1;TSGA10 -0.63 -8.67 -0.43 2.03e-16 Chronic sinus infection; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg24469923 chr19:11925456 ZNF440 0.4 6.68 0.35 1.02e-10 Liver disease severity in Alagille syndrome; CRC cis rs6424115 0.830 rs6672157 chr1:24198840 C/G cg09473613 chr1:24152604 HMGCL 0.34 5.63 0.3 3.83e-8 Immature fraction of reticulocytes; CRC cis rs6546324 0.615 rs4233939 chr2:67782735 A/C cg15745817 chr2:67799979 NA -0.51 -8.35 -0.42 1.9e-15 Endometriosis; CRC cis rs10504229 1.000 rs61998258 chr8:58192284 T/C cg24829409 chr8:58192753 C8orf71 -0.68 -11.34 -0.53 2.27e-25 Developmental language disorder (linguistic errors); CRC cis rs11122272 0.735 rs2491405 chr1:231513431 C/A cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.54 -8.11 -0.41 1.04e-14 Hemoglobin concentration; CRC cis rs2976388 1.000 rs2920298 chr8:143763043 A/G cg24046110 chr8:143859143 LYNX1 -0.37 -6.32 -0.33 8.7e-10 Urinary tract infection frequency; CRC cis rs7584330 0.554 rs10185109 chr2:238435546 T/C cg16989719 chr2:238392110 NA -0.35 -5.91 -0.31 8.35e-9 Prostate cancer; CRC cis rs769267 0.930 rs1063966 chr19:19616742 G/A cg02546618 chr19:19431379 KIAA0892;SF4 0.44 6.08 0.32 3.33e-9 Tonsillectomy; CRC cis rs4727027 0.866 rs1358062 chr7:148783743 T/C cg12479418 chr7:148823350 ZNF425;ZNF398 0.43 5.72 0.3 2.46e-8 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC cis rs9611565 0.694 rs202613 chr22:41821993 C/A cg03806693 chr22:41940476 POLR3H 1.1 13.52 0.6 1.95e-33 Vitiligo; CRC cis rs2303745 0.544 rs6512181 chr19:17399213 T/G cg02221750 chr19:17393354 ANKLE1 -0.46 -6.8 -0.35 5.03e-11 Systemic lupus erythematosus; CRC trans rs1005277 0.579 rs1780115 chr10:38524773 C/T cg27523141 chr10:43048294 ZNF37B 0.47 6.9 0.36 2.69e-11 Extrinsic epigenetic age acceleration; CRC cis rs9914988 0.887 rs11652710 chr17:27145075 C/T cg20469991 chr17:27169893 C17orf63 -0.59 -7.19 -0.37 4.48e-12 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs9291683 0.546 rs6820188 chr4:10051655 C/T cg11266682 chr4:10021025 SLC2A9 0.51 10.47 0.5 2.52e-22 Bone mineral density; CRC cis rs1218582 0.596 rs11264275 chr1:154825270 G/T cg24250549 chr1:154909240 PMVK -0.43 -6.47 -0.34 3.52e-10 Prostate cancer; CRC cis rs11864453 0.647 rs9941346 chr16:72135707 C/G cg23815491 chr16:72088622 HP 0.49 7.51 0.38 5.77e-13 Fibrinogen levels; CRC cis rs738322 0.600 rs7286105 chr22:38557821 A/G cg03162506 chr22:38580953 NA 0.28 6.0 0.31 5.31e-9 Cutaneous nevi; CRC trans rs11165623 0.564 rs11165658 chr1:96985670 A/G cg10631902 chr5:14652156 NA -0.4 -7.08 -0.36 8.67e-12 Hip circumference;Waist circumference; CRC cis rs2251381 0.750 rs2255055 chr21:30537045 C/T cg08807101 chr21:30365312 RNF160 0.61 9.24 0.45 3.26e-18 Selective IgA deficiency; CRC cis rs4924935 1.000 rs4924935 chr17:18753870 C/T cg26378065 chr17:18585709 ZNF286B 0.44 5.94 0.31 7.21e-9 Pancreatic cancer; CRC cis rs8060686 0.641 rs79323429 chr16:68084594 A/G cg08314208 chr16:67682810 RLTPR -0.63 -6.58 -0.34 1.87e-10 HDL cholesterol;Metabolic syndrome; CRC cis rs9039 0.959 rs12925781 chr16:9216914 A/G cg08831531 chr16:9218945 NA 0.58 6.82 0.35 4.31e-11 Menopause (age at onset); CRC trans rs8002861 0.905 rs12873099 chr13:44396247 G/A cg12856521 chr11:46389249 DGKZ -0.42 -6.56 -0.34 2.07e-10 Leprosy; CRC cis rs3736485 0.966 rs12101730 chr15:51800733 C/T cg08986416 chr15:51914746 DMXL2 -0.42 -6.08 -0.32 3.4e-9 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs4423214 1.000 rs12808368 chr11:71170817 C/T cg05163923 chr11:71159392 DHCR7 0.65 9.16 0.45 5.88e-18 Vitamin D levels; CRC cis rs2836950 0.501 rs62223052 chr21:40708702 A/C cg11644478 chr21:40555479 PSMG1 -0.45 -6.36 -0.33 6.59e-10 Menarche (age at onset); CRC cis rs3020333 0.875 rs2982571 chr6:152012739 A/T cg22157087 chr6:152012887 ESR1 -0.53 -8.03 -0.4 1.78e-14 Total body bone mineral density; CRC trans rs10411161 0.702 rs7250138 chr19:52385232 G/C cg22319618 chr22:45562946 NUP50 -0.69 -7.66 -0.39 2.13e-13 Breast cancer; CRC cis rs9467711 0.606 rs34104395 chr6:26478252 C/T cg08501292 chr6:25962987 TRIM38 0.88 6.0 0.31 5.23e-9 Autism spectrum disorder or schizophrenia; CRC cis rs13217239 0.646 rs12209886 chr6:26984757 G/A cg18867708 chr6:26865862 GUSBL1 0.38 5.82 0.31 1.39e-8 Schizophrenia; CRC cis rs8099014 0.861 rs17669 chr18:56118493 C/T cg12907477 chr18:56117327 MIR122 0.47 5.91 0.31 8.48e-9 Platelet count; CRC cis rs6089584 0.854 rs6061985 chr20:60622362 T/C cg23262073 chr20:60523788 NA -0.45 -7.08 -0.36 8.54e-12 Body mass index; CRC cis rs561341 0.609 rs7214626 chr17:30190989 G/A cg13647721 chr17:30228624 UTP6 -0.63 -7.19 -0.37 4.38e-12 Hip circumference adjusted for BMI; CRC cis rs6681460 1.000 rs6656550 chr1:67122552 C/T cg02459107 chr1:67143332 SGIP1 0.48 8.38 0.42 1.51e-15 Presence of antiphospholipid antibodies; CRC cis rs7208859 0.573 rs58920731 chr17:29191746 G/T cg13385521 chr17:29058706 SUZ12P 0.65 7.73 0.39 1.31e-13 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC trans rs1945213 0.659 rs17149979 chr11:55840862 A/G cg03929089 chr4:120376271 NA 0.56 6.35 0.33 7.04e-10 Acute lymphoblastic leukemia (childhood); CRC cis rs6951245 0.706 rs28483034 chr7:1170171 C/A cg20603222 chr7:1096387 C7orf50;GPR146 -0.63 -7.91 -0.4 3.97e-14 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs11758351 1.000 rs16891405 chr6:26204506 A/G cg01420254 chr6:26195488 NA 0.79 8.61 0.43 3e-16 Gout;Renal underexcretion gout; CRC cis rs2976388 0.533 rs12543368 chr8:143819450 T/C cg22687807 chr8:143858763 LYNX1 -0.44 -6.92 -0.36 2.32e-11 Urinary tract infection frequency; CRC cis rs6701037 0.748 rs10912901 chr1:175138602 G/A cg00321850 chr1:175162397 KIAA0040 -0.4 -6.59 -0.34 1.78e-10 Alcohol dependence; CRC cis rs9486719 1.000 rs11153064 chr6:97021959 A/G cg06623918 chr6:96969491 KIAA0776 -0.82 -9.53 -0.47 3.58e-19 Migraine;Coronary artery disease; CRC cis rs72781680 0.898 rs17762651 chr2:24115922 A/G cg08917208 chr2:24149416 ATAD2B 0.87 8.59 0.43 3.46e-16 Lymphocyte counts; CRC cis rs9487051 0.872 rs7773331 chr6:109609208 C/T cg21918786 chr6:109611834 NA -0.45 -8.32 -0.42 2.32e-15 Reticulocyte fraction of red cells; CRC cis rs13108904 0.935 rs2199956 chr4:1248919 A/G cg02018176 chr4:1364513 KIAA1530 0.47 8.01 0.4 2e-14 Obesity-related traits; CRC cis rs6570726 0.599 rs9403725 chr6:145897622 A/T cg13319975 chr6:146136371 FBXO30 0.6 8.77 0.44 1e-16 Lobe attachment (rater-scored or self-reported); CRC cis rs2732480 0.577 rs2634684 chr12:48730875 C/T cg21466736 chr12:48725269 NA 0.62 9.19 0.45 4.7e-18 Hemoglobin concentration;Red blood cell count;Hematocrit; CRC cis rs35146811 0.695 rs1618851 chr7:99810643 T/G cg00553149 chr7:99775558 STAG3;GPC2 -0.24 -5.61 -0.3 4.38e-8 Coronary artery disease; CRC cis rs28386778 1.000 rs3020613 chr17:61955983 A/G cg11494091 chr17:61959527 GH2 0.61 10.41 0.5 3.98e-22 Prudent dietary pattern; CRC cis rs2836974 1.000 rs12710454 chr21:40656919 A/G cg06238570 chr21:40685208 BRWD1 0.76 10.4 0.5 4.39e-22 Cognitive function; CRC cis rs2281845 0.826 rs4915215 chr1:201077212 C/T cg08885800 chr1:201084119 NA -0.43 -7.78 -0.39 9.18e-14 Permanent tooth development; CRC cis rs1570884 0.516 rs9316462 chr13:50176321 A/G cg02321871 chr13:50159138 RCBTB1 -0.45 -6.32 -0.33 8.5e-10 Sum basophil neutrophil counts;Sum neutrophil eosinophil counts;Neutrophil count;Myeloid white cell count;Granulocyte count; CRC cis rs6696846 0.715 rs12139373 chr1:205054879 A/C cg00857998 chr1:205179979 DSTYK 0.46 6.2 0.32 1.73e-9 Red blood cell count; CRC cis rs910316 0.934 rs8016330 chr14:75657507 G/T cg11812906 chr14:75593930 NEK9 -0.5 -7.4 -0.38 1.15e-12 Height; CRC cis rs8099014 0.906 rs4940693 chr18:56101171 T/G cg19312305 chr18:56117016 MIR122 -0.4 -6.2 -0.32 1.72e-9 Platelet count; CRC cis rs798554 0.704 rs798512 chr7:2782592 C/G cg13628971 chr7:2884303 GNA12 0.45 7.04 0.36 1.16e-11 Height; CRC cis rs13064411 0.660 rs11916690 chr3:113012343 A/C cg10517650 chr3:113235015 CCDC52 -0.36 -5.75 -0.3 2e-8 Response to simvastatin treatment (PCSK9 protein level change); CRC cis rs477692 0.685 rs551491 chr10:131397821 G/A cg05714579 chr10:131428358 MGMT 0.52 7.14 0.37 6.21e-12 Response to temozolomide; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg25733915 chr17:40829168 PLEKHH3 0.53 6.88 0.35 3.12e-11 Thyroid stimulating hormone; CRC cis rs7845219 0.544 rs34208552 chr8:95908067 C/G cg16049864 chr8:95962084 TP53INP1 -0.43 -6.57 -0.34 1.93e-10 Type 2 diabetes; CRC cis rs3806843 0.966 rs2563265 chr5:140137005 C/T cg19875535 chr5:140030758 IK -0.59 -9.66 -0.47 1.36e-19 Depressive symptoms (multi-trait analysis); CRC cis rs7202877 0.706 rs37605 chr16:75506572 G/C cg03315344 chr16:75512273 CHST6 -0.53 -6.26 -0.33 1.2e-9 Type 2 diabetes;Type 1 diabetes; CRC cis rs6831256 0.583 rs10937929 chr4:3483037 C/T cg17706124 chr4:3521738 LRPAP1 0.41 5.94 0.31 7.13e-9 LDL cholesterol;Triglyceride levels;Triglycerides;Cholesterol, total; CRC trans rs6598955 0.671 rs10493030 chr1:26561856 T/C cg07461501 chr17:79650226 HGS;ARL16 -0.51 -6.03 -0.32 4.29e-9 Obesity-related traits; CRC cis rs9400271 0.632 rs9374072 chr6:109591586 A/G cg01475377 chr6:109611718 NA -0.35 -6.07 -0.32 3.56e-9 Sum neutrophil eosinophil counts;Sum basophil neutrophil counts;White blood cell count;Neutrophil count;Myeloid white cell count;Granulocyte count; CRC cis rs9311676 0.632 rs6785572 chr3:58361517 A/G cg06643156 chr3:58380774 PXK -0.44 -6.76 -0.35 6.17e-11 Systemic lupus erythematosus; CRC cis rs7412746 0.658 rs6660845 chr1:150841066 G/A cg15448220 chr1:150897856 SETDB1 0.55 7.74 0.39 1.22e-13 Melanoma; CRC cis rs2386661 0.547 rs57893347 chr10:5646191 G/A cg02449762 chr10:5661741 NA -0.34 -5.87 -0.31 1.04e-8 Breast cancer; CRC cis rs12142240 0.698 rs56130131 chr1:46861306 A/C cg14993813 chr1:46806288 NSUN4 -0.48 -6.05 -0.32 3.88e-9 Menopause (age at onset); CRC cis rs62229266 0.609 rs12482541 chr21:37419743 A/G cg08632701 chr21:37451849 NA -0.4 -6.27 -0.33 1.14e-9 Mitral valve prolapse; CRC cis rs6952808 0.608 rs58120505 chr7:2029867 T/C cg00106254 chr7:1943704 MAD1L1 -0.45 -6.76 -0.35 6.14e-11 Bipolar disorder and schizophrenia; CRC cis rs4862750 0.832 rs9995958 chr4:187901764 G/A cg22105103 chr4:187893119 NA 0.64 11.71 0.54 1.01e-26 Lobe attachment (rater-scored or self-reported); CRC cis rs7591163 1.000 rs4300818 chr2:228713255 G/T cg01216370 chr2:228736459 WDR69 -0.45 -5.7 -0.3 2.68e-8 Blood pressure; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg03321319 chr22:22222323 MAPK1 0.37 6.04 0.32 4.06e-9 Liver disease severity in Alagille syndrome; CRC trans rs10838798 0.584 rs17198859 chr11:48140354 C/A cg21153622 chr11:89784906 NA -0.43 -6.68 -0.35 1.03e-10 Height; CRC cis rs77633900 0.614 rs2469244 chr15:76884127 G/A cg21673338 chr15:77095150 SCAPER -0.72 -7.07 -0.36 9.49e-12 Non-glioblastoma glioma;Glioma; CRC cis rs8180040 0.800 rs11130126 chr3:47306894 A/G cg10298567 chr3:47292165 KIF9 0.42 6.56 0.34 2.07e-10 Colorectal cancer; CRC cis rs10504229 0.728 rs78765835 chr8:58154337 A/G cg24829409 chr8:58192753 C8orf71 -0.58 -7.96 -0.4 2.86e-14 Developmental language disorder (linguistic errors); CRC cis rs6662572 0.703 rs72690847 chr1:46256929 A/G cg03123370 chr1:45965343 CCDC163P;MMACHC 0.47 6.0 0.31 5.08e-9 Blood protein levels; CRC cis rs7635838 0.892 rs2880897 chr3:11494544 A/G cg00170343 chr3:11313890 ATG7 0.41 6.23 0.32 1.4e-9 HDL cholesterol; CRC cis rs9788333 0.792 rs34479949 chr13:21895574 G/A cg21970626 chr13:21893289 NA -0.46 -8.86 -0.44 5.17e-17 Thiazide-induced adverse metabolic effects in hypertensive patients; CRC cis rs7666738 0.645 rs10013290 chr4:99082799 G/A cg05340658 chr4:99064831 C4orf37 0.51 7.61 0.39 2.83e-13 Colonoscopy-negative controls vs population controls; CRC cis rs501120 1.000 rs527785 chr10:44762686 G/A cg09554077 chr10:44749378 NA 0.78 11.96 0.55 1.33e-27 Coronary artery disease;Coronary heart disease; CRC cis rs3749237 0.964 rs35210174 chr3:49812606 C/T cg03060546 chr3:49711283 APEH 0.51 7.7 0.39 1.61e-13 Resting heart rate; CRC cis rs4474465 1.000 rs10899511 chr11:78170923 T/A cg27205649 chr11:78285834 NARS2 -0.48 -5.85 -0.31 1.18e-8 Alzheimer's disease (survival time); CRC trans rs7819412 0.645 rs10156356 chr8:11046209 T/C cg16141378 chr3:129829833 LOC729375 0.44 6.72 0.35 8.13e-11 Triglycerides; CRC trans rs2303319 1.000 rs12471336 chr2:162265189 A/C cg15640062 chr1:25757265 TMEM57 0.81 5.97 0.31 6.19e-9 Cognitive function; CRC cis rs2228479 0.850 rs11639788 chr16:89807543 G/A cg19635926 chr16:89946313 TCF25 0.66 5.98 0.31 5.71e-9 Skin colour saturation; CRC cis rs4319547 0.626 rs10744210 chr12:122931793 A/G cg05707623 chr12:122985044 ZCCHC8 -0.75 -9.27 -0.46 2.46e-18 Body mass index; CRC cis rs58688157 0.705 rs2396545 chr11:601785 T/C cg01842473 chr11:617407 IRF7;MUPCDH -0.57 -7.0 -0.36 1.42e-11 Systemic lupus erythematosus; CRC cis rs2302190 0.882 rs9901693 chr17:56606915 C/T cg12560992 chr17:57184187 TRIM37 0.51 6.09 0.32 3.2e-9 Vitamin D levels; CRC cis rs9322193 0.923 rs12660304 chr6:150060783 A/G cg04369109 chr6:150039330 LATS1 -0.41 -5.81 -0.31 1.47e-8 Lung cancer; CRC cis rs7811142 0.775 rs1636980 chr7:99938864 A/G cg07160278 chr7:100027354 MEPCE;ZCWPW1 -1.06 -15.05 -0.64 2.51e-39 Platelet count; CRC trans rs3942852 0.806 rs4752893 chr11:48118604 C/T cg03929089 chr4:120376271 NA -0.55 -7.08 -0.36 9.03e-12 Acute lymphoblastic leukemia (childhood); CRC cis rs4938330 0.608 rs3830008 chr11:117093764 A/C cg01368799 chr11:117014884 PAFAH1B2 -0.48 -6.22 -0.32 1.54e-9 Blood protein levels; CRC trans rs11165623 0.564 rs7555035 chr1:96996026 T/C cg10631902 chr5:14652156 NA -0.4 -6.86 -0.35 3.48e-11 Hip circumference;Waist circumference; CRC cis rs4319547 0.620 rs12372756 chr12:122815130 A/G cg05707623 chr12:122985044 ZCCHC8 -0.69 -8.35 -0.42 1.89e-15 Body mass index; CRC cis rs523522 0.962 rs7488320 chr12:120981630 G/T cg27279351 chr12:120934652 DYNLL1 0.77 11.31 0.53 2.78e-25 High light scatter reticulocyte count; CRC cis rs25645 0.502 rs7209742 chr17:38108708 A/G cg17344932 chr17:38183730 MED24;SNORD124 -0.56 -8.92 -0.44 3.24e-17 Myeloid white cell count; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg13842258 chr4:41216271 APBB2 0.42 6.49 0.34 3.1e-10 Liver disease severity in Alagille syndrome; CRC cis rs812925 0.502 rs2053750 chr2:61656273 T/A cg10580144 chr2:61372316 C2orf74 -0.32 -6.78 -0.35 5.42e-11 Immature fraction of reticulocytes; CRC cis rs67311347 0.955 rs4974067 chr3:40374551 C/T cg09455208 chr3:40491958 NA 0.42 8.32 0.42 2.35e-15 Renal cell carcinoma; CRC cis rs2535633 0.594 rs2581789 chr3:53096230 C/T cg15147215 chr3:52552868 STAB1 0.44 6.92 0.36 2.33e-11 Body mass index; CRC cis rs12980942 0.810 rs3745295 chr19:41785282 T/G cg25627403 chr19:41769009 HNRNPUL1 0.46 5.62 0.3 4.16e-8 Coronary artery disease; CRC cis rs6694672 1.000 rs6694672 chr1:196945789 T/G cg13682187 chr1:196946512 CFHR5 -0.52 -8.16 -0.41 7.37e-15 Asthma; CRC cis rs1799949 0.501 rs9675035 chr17:41415016 A/T cg19454999 chr17:41278357 BRCA1;NBR2 0.52 8.15 0.41 7.64e-15 Menopause (age at onset); CRC trans rs11098499 0.644 rs34835603 chr4:120553428 C/T cg25214090 chr10:38739885 LOC399744 0.58 9.08 0.45 1.06e-17 Corneal astigmatism; CRC cis rs10504229 0.953 rs66676208 chr8:58173866 C/T cg01721255 chr8:58191610 C8orf71 0.49 6.17 0.32 2e-9 Developmental language disorder (linguistic errors); CRC cis rs780094 0.500 rs12478841 chr2:27811722 A/G cg27432699 chr2:27873401 GPN1 0.48 6.33 0.33 8.08e-10 Calcium levels;Fasting blood insulin;Metabolic traits;Triglyceride levels;Fasting plasma glucose;Urate levels in overweight individuals;Urate levels in obese individuals;Uric acid levels;Height;Age-related diseases, mortality and associated endophenotypes;Renal underexcretion gout;Fasting blood glucose (BMI interaction);Urate levels;Gondoic acid (20:1n-9) levels;Fasting blood insulin (BMI interaction);Triglycerides;Plasma omega-3 polyunsaturated fatty acid levels (docosapentaenoic acid);Type 2 diabetes;Nonalcoholic fatty liver disease;Hypertriglyceridemia;C-reactive protein;Age-related disease endophenotypes;LDL cholesterol;Metabolic syndrome;Crohn's disease;Alcohol consumption (drinks per week);Homeostasis model assessment of insulin resistance;Alcohol consumption;Red blood cell count;Fasting blood glucose; CRC cis rs10046574 0.831 rs75959757 chr7:135170755 G/A cg27474649 chr7:135195673 CNOT4 0.7 5.8 0.3 1.52e-8 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs736408 0.716 rs2239550 chr3:52822509 G/C cg18099408 chr3:52552593 STAB1 -0.41 -6.39 -0.33 5.63e-10 Bipolar disorder; CRC cis rs7659604 0.605 rs2071486 chr4:122740162 C/T cg19748678 chr4:122722346 EXOSC9 0.58 9.32 0.46 1.71e-18 Type 2 diabetes; CRC cis rs6495122 0.644 rs62029217 chr15:75261899 C/T cg09165964 chr15:75287851 SCAMP5 0.55 8.26 0.41 3.58e-15 Caffeine consumption;Diastolic blood pressure;Coffee consumption; CRC trans rs7824557 0.872 rs1347410 chr8:11111242 G/A cg06636001 chr8:8085503 FLJ10661 -0.44 -6.3 -0.33 9.71e-10 Retinal vascular caliber; CRC cis rs67311347 1.000 rs9841335 chr3:40475858 G/A cg24209194 chr3:40518798 ZNF619 0.42 6.33 0.33 8.25e-10 Renal cell carcinoma; CRC cis rs908922 0.573 rs7544564 chr1:152527007 A/C cg23254163 chr1:152506842 NA 0.45 8.98 0.44 2.16e-17 Hair morphology; CRC cis rs3020333 0.721 rs1293936 chr6:152017691 T/G cg22157087 chr6:152012887 ESR1 0.47 7.24 0.37 3.11e-12 Total body bone mineral density; CRC cis rs2859741 0.528 rs2359647 chr1:37483054 A/T cg09363841 chr1:37513479 NA -0.45 -7.0 -0.36 1.43e-11 Forced expiratory volume in 1 second (environmental tobacco smoke interaction); CRC cis rs2120019 1.000 rs12910644 chr15:75358388 A/G cg17294928 chr15:75287854 SCAMP5 -0.78 -11.67 -0.54 1.4e-26 Blood trace element (Zn levels); CRC cis rs11031096 0.711 rs4910890 chr11:4153407 C/T cg18678763 chr11:4115507 RRM1 -0.51 -8.43 -0.42 1.09e-15 Mean corpuscular volume;Mean corpuscular hemoglobin; CRC cis rs1707322 0.789 rs7540578 chr1:46252144 C/T cg06784218 chr1:46089804 CCDC17 0.59 10.79 0.51 1.91e-23 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs2836974 0.897 rs13052882 chr21:40555351 G/C cg11644478 chr21:40555479 PSMG1 0.84 13.42 0.59 4.84e-33 Cognitive function; CRC cis rs6761276 0.649 rs3811057 chr2:113831188 C/A cg24553058 chr2:113831203 IL1F10 0.55 8.64 0.43 2.47e-16 Protein quantitative trait loci; CRC cis rs13256369 0.951 rs10503394 chr8:8565775 A/G cg00074818 chr8:8560427 CLDN23 0.38 6.95 0.36 1.95e-11 Obesity-related traits; CRC cis rs2806561 0.704 rs636940 chr1:23522967 A/T cg12483005 chr1:23474871 LUZP1 0.49 7.01 0.36 1.33e-11 Height; CRC cis rs7412746 0.611 rs12410869 chr1:150856153 G/T cg15448220 chr1:150897856 SETDB1 0.46 6.53 0.34 2.52e-10 Melanoma; CRC trans rs7937682 0.889 rs493810 chr11:111491888 G/T cg18187862 chr3:45730750 SACM1L 0.45 6.55 0.34 2.23e-10 Primary sclerosing cholangitis; CRC cis rs2439831 0.850 rs12440573 chr15:44108997 A/G cg02155558 chr15:43621948 ADAL;LCMT2 0.72 7.95 0.4 2.99e-14 Lung cancer in ever smokers; CRC trans rs6550704 0.687 rs9865314 chr3:22634337 A/G cg08504905 chr19:54663436 LENG1 -0.41 -5.97 -0.31 6.27e-9 Daytime sleep phenotypes; CRC trans rs7944735 0.517 rs74763661 chr11:48233772 T/C cg27395922 chr11:50257633 LOC441601 0.48 6.16 0.32 2.16e-9 Intraocular pressure; CRC cis rs7264396 0.943 rs224431 chr20:34153599 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.44 -7.15 -0.37 5.83e-12 Total cholesterol levels; CRC cis rs7103648 0.897 rs11606287 chr11:47407439 C/A cg20307385 chr11:47447363 PSMC3 0.91 15.21 0.64 5.95e-40 Diastolic blood pressure;Systolic blood pressure; CRC trans rs1656966 1.000 rs1656966 chr3:186466252 C/T cg14158573 chr20:17549682 DSTN 0.39 6.73 0.35 7.64e-11 Myopia (pathological); CRC cis rs4731207 0.672 rs62478914 chr7:124456654 G/A cg23710748 chr7:124431027 NA 0.38 6.08 0.32 3.42e-9 Cutaneous malignant melanoma; CRC cis rs2762353 0.595 rs1892256 chr6:25754271 C/T cg15691649 chr6:25882328 NA 0.48 6.17 0.32 1.99e-9 Blood metabolite levels; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg19161053 chr7:99036702 CPSF4;PTCD1 0.48 6.89 0.36 2.82e-11 Response to antipsychotic treatment; CRC trans rs6550704 0.687 rs9865314 chr3:22634337 A/G cg25635840 chr17:26898051 PIGS -0.43 -6.4 -0.33 5.22e-10 Daytime sleep phenotypes; CRC cis rs2836974 0.568 rs377098 chr21:40535216 G/A cg11890956 chr21:40555474 PSMG1 -0.92 -16.78 -0.68 4.34e-46 Cognitive function; CRC cis rs7677751 0.806 rs60806423 chr4:55086816 C/T cg13615338 chr4:55094005 PDGFRA 0.42 6.05 0.32 4e-9 Corneal astigmatism; CRC cis rs13256369 0.826 rs12678414 chr8:8586016 G/T cg06671706 chr8:8559999 CLDN23 0.57 8.46 0.42 8.8e-16 Obesity-related traits; CRC cis rs9341808 0.727 rs10943697 chr6:80931506 A/C cg08355045 chr6:80787529 NA 0.43 6.83 0.35 4.15e-11 Sitting height ratio; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg06129794 chr4:53578476 SNORA26;KIAA0114 0.37 5.97 0.31 6.25e-9 Liver disease severity in Alagille syndrome; CRC cis rs4728302 0.869 rs6955279 chr7:133612113 C/T cg10665199 chr7:133106180 EXOC4 0.4 5.92 0.31 8.3e-9 Intelligence;Intelligence (multi-trait analysis); CRC cis rs2985684 0.948 rs6572592 chr14:50080871 G/A cg10008539 chr14:50087325 RPL36AL;MGAT2 -0.46 -6.1 -0.32 2.92e-9 Carotid intima media thickness; CRC cis rs9611565 0.802 rs73176692 chr22:41785735 G/A cg03806693 chr22:41940476 POLR3H -1.01 -12.7 -0.57 2.36e-30 Vitiligo; CRC cis rs2652834 1.000 rs2729785 chr15:63402574 G/A cg05507819 chr15:63340323 TPM1 0.44 5.61 0.3 4.19e-8 HDL cholesterol; CRC cis rs1223397 0.938 rs35511719 chr6:13282442 T/C cg21538684 chr6:13274180 PHACTR1 0.47 5.65 0.3 3.39e-8 Blood pressure; CRC cis rs7827545 0.620 rs6578009 chr8:135522989 T/C cg17885191 chr8:135476712 NA -0.56 -7.42 -0.38 1.03e-12 Hypertension (SNP x SNP interaction); CRC cis rs9525927 0.570 rs7400099 chr13:44804480 G/T cg19190762 chr13:44806055 NA -0.61 -8.25 -0.41 3.74e-15 Dupuytren's disease; CRC cis rs10504229 0.906 rs113823909 chr8:58170635 A/G cg02290350 chr8:58132656 NA -0.42 -5.94 -0.31 7.42e-9 Developmental language disorder (linguistic errors); CRC cis rs769267 0.929 rs2905421 chr19:19457908 G/T cg02546618 chr19:19431379 KIAA0892;SF4 0.49 6.79 0.35 5.24e-11 Tonsillectomy; CRC cis rs7264396 0.635 rs6121102 chr20:34544274 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.6 -9.71 -0.47 9.15e-20 Total cholesterol levels; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg25547232 chr19:1026491 CNN2 0.41 6.51 0.34 2.76e-10 Intelligence (multi-trait analysis); CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg18467133 chr12:100661475 SCYL2;DEPDC4 -0.4 -5.97 -0.31 6.08e-9 Myopia (pathological); CRC cis rs7224685 0.501 rs6502770 chr17:4007314 A/G cg11204139 chr17:3907470 NA 0.64 11.14 0.52 1.11e-24 Type 2 diabetes; CRC cis rs875971 1.000 rs6956179 chr7:65806659 C/T cg11764359 chr7:65958608 NA -0.63 -10.33 -0.49 7.44e-22 Aortic root size; CRC cis rs7178572 0.568 rs7167794 chr15:77635875 T/C cg22256960 chr15:77711686 NA -0.64 -9.37 -0.46 1.18e-18 Type 2 diabetes; CRC trans rs783540 0.967 rs34186444 chr15:83287500 A/G cg18393722 chr15:85113863 UBE2QP1 -0.36 -5.98 -0.31 5.78e-9 Schizophrenia; CRC cis rs6963495 0.818 rs73190149 chr7:105152793 C/T cg02135003 chr7:105160482 PUS7 -0.9 -12.16 -0.56 2.37e-28 Bipolar disorder (body mass index interaction); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg08063724 chr1:40367097 MYCL1 0.39 6.05 0.32 3.89e-9 Liver disease severity in Alagille syndrome; CRC cis rs12791968 1.000 rs11038237 chr11:45001880 C/T cg11846598 chr11:44996168 LOC221122 -0.73 -13.08 -0.59 8.75e-32 Inhibitory control; CRC trans rs1455244 0.700 rs7229302 chr18:11508904 G/T cg01858229 chr12:109125404 CORO1C 0.42 6.31 0.33 9.13e-10 Schizophrenia; CRC cis rs12291225 0.639 rs61883858 chr11:14294708 C/T cg05501817 chr11:14380813 RRAS2 -0.45 -5.94 -0.31 7.15e-9 Sense of smell; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg08380957 chr17:58678329 PPM1D 0.47 6.63 0.34 1.41e-10 Response to antipsychotic treatment; CRC cis rs4243830 0.850 rs12029123 chr1:6607142 C/T cg05709478 chr1:6581295 PLEKHG5 0.67 7.92 0.4 3.74e-14 Body mass index; CRC cis rs7811142 0.667 rs3873746 chr7:99935097 G/A cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.11 16.52 0.67 4.75e-45 Platelet count; CRC cis rs6460942 0.915 rs75732743 chr7:12454095 C/T cg06484146 chr7:12443880 VWDE -0.78 -8.1 -0.41 1.11e-14 Coronary artery disease; CRC cis rs4713118 0.621 rs9368548 chr6:28034737 A/G cg25164649 chr6:28176230 NA 0.7 8.9 0.44 3.71e-17 Parkinson's disease; CRC cis rs9682041 0.561 rs9856511 chr3:170140165 C/G cg11886554 chr3:170076028 SKIL 0.65 7.53 0.38 4.94e-13 Glomerular filtration rate in non diabetics (creatinine);Glomerular filtration rate (creatinine); CRC trans rs11885103 0.543 rs1320364 chr2:563219 A/G cg12228919 chr15:44955936 SPG11 -0.46 -6.87 -0.35 3.13e-11 Heschl's gyrus morphology; CRC trans rs6430538 0.646 rs6734820 chr2:135536808 A/G cg21512817 chr2:216176813 ATIC 0.37 6.12 0.32 2.63e-9 Parkinson's disease; CRC cis rs1451375 0.527 rs6950777 chr7:50597056 G/A cg18232548 chr7:50535776 DDC 0.46 6.43 0.33 4.5e-10 Malaria; CRC cis rs7173389 0.530 rs6495062 chr15:73682691 T/C cg01796676 chr15:73680284 NA 0.56 8.54 0.43 4.88e-16 Resting heart rate; CRC cis rs10193935 0.901 rs6727657 chr2:42632117 A/G cg27598129 chr2:42591480 NA -0.62 -7.61 -0.39 2.82e-13 Colonoscopy-negative controls vs population controls; CRC cis rs3820068 0.581 rs6666373 chr1:15939884 A/T cg13390004 chr1:15929781 NA 0.5 7.04 0.36 1.12e-11 Systolic blood pressure; CRC cis rs2032447 0.839 rs199751 chr6:26015583 T/C cg27635394 chr6:26043820 HIST1H2BB 0.45 6.54 0.34 2.36e-10 Intelligence (multi-trait analysis); CRC cis rs921968 0.565 rs6436069 chr2:219597185 T/C cg02176678 chr2:219576539 TTLL4 -0.39 -6.19 -0.32 1.76e-9 Mean corpuscular hemoglobin concentration; CRC cis rs7215564 0.908 rs4536520 chr17:78660239 C/T cg09596252 chr17:78655493 RPTOR 0.54 5.73 0.3 2.25e-8 Myopia (pathological); CRC cis rs7659604 0.676 rs4516739 chr4:122699741 G/T cg06713675 chr4:122721982 EXOSC9 -0.51 -8.3 -0.42 2.77e-15 Type 2 diabetes; CRC cis rs72945132 0.678 rs12786421 chr11:70235314 G/C cg14191688 chr11:70257035 CTTN 0.58 7.9 0.4 4.21e-14 Coronary artery disease; CRC trans rs10504390 0.527 rs4392943 chr8:66523799 C/A cg26403416 chr21:43771339 TFF2 0.6 6.14 0.32 2.38e-9 IgG glycosylation; CRC cis rs4713118 0.784 rs9468219 chr6:27731755 C/A cg06470822 chr6:28175283 NA 0.72 9.7 0.47 1e-19 Parkinson's disease; CRC cis rs7618915 0.547 rs34610878 chr3:52759169 G/C cg07507251 chr3:52567010 NT5DC2 0.4 5.75 0.3 2.04e-8 Bipolar disorder; CRC cis rs8180040 0.653 rs6808742 chr3:47051512 G/A cg02527881 chr3:46936655 PTH1R -0.39 -7.07 -0.36 9.33e-12 Colorectal cancer; CRC cis rs1451375 0.652 rs10249420 chr7:50623451 C/G cg14593290 chr7:50529359 DDC -0.6 -7.91 -0.4 3.95e-14 Malaria; CRC cis rs10504229 0.683 rs7820302 chr8:58142502 C/T cg05313129 chr8:58192883 C8orf71 -0.41 -5.93 -0.31 7.68e-9 Developmental language disorder (linguistic errors); CRC cis rs1881797 1.000 rs7527856 chr1:247688139 C/T cg05639522 chr1:247681581 NA 0.45 6.74 0.35 6.9e-11 Acute lymphoblastic leukemia (childhood); CRC trans rs4650994 0.525 rs2493858 chr1:178541210 A/G cg05059571 chr16:84539110 KIAA1609 -0.61 -8.32 -0.42 2.45e-15 HDL cholesterol levels;HDL cholesterol; CRC cis rs34375054 0.672 rs58416336 chr12:125606428 G/T cg05341575 chr12:125625032 AACS -0.34 -5.91 -0.31 8.52e-9 Post bronchodilator FEV1/FVC ratio; CRC cis rs6840360 1.000 rs4696109 chr4:152668785 A/C cg09659197 chr4:152720779 NA 0.53 11.71 0.54 1.06e-26 Intelligence (multi-trait analysis); CRC cis rs17376456 0.569 rs2045019 chr5:93201971 C/T cg25358565 chr5:93447407 FAM172A -0.65 -7.75 -0.39 1.18e-13 Diabetic retinopathy; CRC cis rs270601 0.913 rs273916 chr5:131659830 C/A cg04518342 chr5:131593106 PDLIM4 0.44 7.05 0.36 1.05e-11 Acylcarnitine levels; CRC cis rs12048904 0.964 rs3188491 chr1:101338482 A/G cg15686842 chr1:101360669 SLC30A7;EXTL2 0.41 5.68 0.3 2.94e-8 Multiple sclerosis; CRC cis rs875971 0.895 rs6460300 chr7:65952924 A/G cg00343986 chr7:65444356 GUSB 0.44 6.39 0.33 5.77e-10 Aortic root size; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg02923393 chr16:1543003 TELO2 0.46 5.98 0.31 5.7e-9 Thyroid stimulating hormone; CRC cis rs17345786 0.911 rs10936707 chr3:101324063 G/A cg11279151 chr3:101281821 RG9MTD1 -0.7 -8.87 -0.44 4.7e-17 Colonoscopy-negative controls vs population controls; CRC cis rs116095464 0.614 rs62344292 chr5:244630 G/A cg22857025 chr5:266934 NA -1.24 -16.45 -0.67 8.57e-45 Breast cancer; CRC cis rs35883536 0.609 rs10783142 chr1:101043902 C/G cg06223162 chr1:101003688 GPR88 -0.36 -6.7 -0.35 8.92e-11 Monocyte count; CRC trans rs4942242 0.663 rs7319346 chr13:44218201 T/C cg26741380 chr15:41871084 TYRO3 -0.45 -6.33 -0.33 7.82e-10 Response to tocilizumab in rheumatoid arthritis; CRC cis rs947211 0.846 rs823155 chr1:205762946 T/C cg26354017 chr1:205819088 PM20D1 0.48 6.98 0.36 1.65e-11 Parkinson's disease; CRC cis rs873946 0.586 rs3793686 chr10:134569559 A/G cg26818010 chr10:134567672 INPP5A -0.65 -8.86 -0.44 5.21e-17 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CRC cis rs875971 0.862 rs9791713 chr7:66105198 C/A cg00343986 chr7:65444356 GUSB -0.45 -6.24 -0.33 1.32e-9 Aortic root size; CRC cis rs875971 1.000 rs6961990 chr7:65888570 C/A cg18912574 chr7:65842487 NCRNA00174 0.35 6.04 0.32 4.23e-9 Aortic root size; CRC cis rs9311676 0.656 rs62258140 chr3:58407083 C/T cg06643156 chr3:58380774 PXK 0.42 6.38 0.33 5.84e-10 Systemic lupus erythematosus; CRC cis rs13082711 0.640 rs35903173 chr3:27287751 T/C cg02860705 chr3:27208620 NA 0.94 11.98 0.55 1.13e-27 Systolic blood pressure;Diastolic blood pressure;Blood pressure; CRC trans rs7705042 0.865 rs6580229 chr5:141510754 A/G cg03701575 chr16:83960119 NA 0.35 5.98 0.31 5.73e-9 Asthma; CRC cis rs6582630 0.519 rs8189549 chr12:38245752 A/G cg26384229 chr12:38710491 ALG10B 0.69 9.22 0.45 3.69e-18 Drug-induced liver injury (flucloxacillin); CRC cis rs9649213 0.593 rs6975156 chr7:97925534 T/C cg24562669 chr7:97807699 LMTK2 0.42 6.99 0.36 1.57e-11 Prostate cancer (SNP x SNP interaction); CRC cis rs709400 0.627 rs62007686 chr14:103899344 A/G cg12935359 chr14:103987150 CKB -0.52 -7.96 -0.4 2.89e-14 Body mass index; CRC cis rs2180341 1.000 rs6569478 chr6:127598619 G/A cg24812749 chr6:127587940 RNF146 0.94 13.67 0.6 5.36e-34 Breast cancer; CRC cis rs1355223 0.583 rs2941041 chr11:34874734 A/C cg24088639 chr11:34937564 PDHX;APIP -0.58 -8.42 -0.42 1.15e-15 Systemic lupus erythematosus and Systemic sclerosis; CRC cis rs2033711 0.728 rs4801586 chr19:58934528 A/G cg13877915 chr19:58951672 ZNF132 0.51 8.45 0.42 9.22e-16 Uric acid clearance; CRC cis rs2032447 0.898 rs807205 chr6:26075035 C/G cg18357526 chr6:26021779 HIST1H4A 0.73 11.18 0.52 8.28e-25 Intelligence (multi-trait analysis); CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg20256961 chr18:71959244 CYB5A 0.46 6.33 0.33 7.89e-10 Anxiety disorder; CRC cis rs12476592 0.516 rs196124 chr2:63854138 A/G cg10828910 chr2:63850056 LOC388955 0.49 6.08 0.32 3.37e-9 Childhood ear infection; CRC cis rs1784581 0.674 rs1789996 chr6:162391895 T/C cg17173639 chr6:162384350 PARK2 -0.7 -11.86 -0.55 3e-27 Itch intensity from mosquito bite; CRC trans rs9956878 0.555 rs8085188 chr18:73544676 A/G cg10190329 chr10:126605450 NA -0.4 -6.5 -0.34 3.01e-10 Obesity-related traits; CRC cis rs28386778 0.897 rs7501614 chr17:61802612 T/C cg25654072 chr17:61904446 PSMC5;FTSJ3 0.72 11.05 0.52 2.36e-24 Prudent dietary pattern; CRC cis rs9435341 0.965 rs61798468 chr1:107569316 T/G cg14828511 chr1:107599125 PRMT6 0.51 6.95 0.36 1.95e-11 Facial morphology (factor 21, depth of nasal alae); CRC cis rs9902453 0.866 rs4795529 chr17:28443549 A/G cg26525008 chr17:28256777 EFCAB5;SSH2 0.69 11.47 0.53 7.31e-26 Coffee consumption (cups per day); CRC cis rs1865760 0.573 rs7450342 chr6:25919480 T/C cg16482183 chr6:26056742 HIST1H1C 0.43 6.39 0.33 5.79e-10 Height; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg14051306 chr5:56248243 MIER3 0.39 6.06 0.32 3.76e-9 Liver disease severity in Alagille syndrome; CRC cis rs1552244 1.000 rs113134644 chr3:10086286 G/A cg08888203 chr3:10149979 C3orf24 0.7 9.86 0.48 2.92e-20 Alzheimer's disease; CRC cis rs12682352 0.652 rs1567398 chr8:8726804 A/C cg06636001 chr8:8085503 FLJ10661 -0.5 -8.02 -0.4 1.92e-14 Neuroticism; CRC cis rs863345 0.604 rs1342953 chr1:158464499 T/C cg12129480 chr1:158549410 OR10X1 -0.3 -6.22 -0.32 1.55e-9 Pneumococcal bacteremia; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg07555182 chr11:82782896 RAB30 0.52 6.79 0.35 5.11e-11 Thyroid stimulating hormone; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg25129765 chr6:99872940 SFRS18 0.44 6.25 0.33 1.28e-9 Response to antipsychotic treatment; CRC cis rs9916302 0.653 rs11654954 chr17:37745979 C/T cg07936489 chr17:37558343 FBXL20 0.54 6.46 0.34 3.71e-10 Glomerular filtration rate (creatinine); CRC cis rs2249625 0.508 rs114505309 chr6:72892383 G/A cg18830697 chr6:72922368 RIMS1 0.41 8.15 0.41 7.57e-15 Acute urticaria and angioedema (non-steroidal anti-inflammatory drug-induced); CRC cis rs9611565 0.840 rs2234059 chr22:41777913 T/C cg06481639 chr22:41940642 POLR3H -0.5 -5.66 -0.3 3.31e-8 Vitiligo; CRC trans rs1590305 0.686 rs7337526 chr13:38061307 C/T cg00807959 chr1:48176281 NA 0.56 5.96 0.31 6.44e-9 Hip geometry; CRC trans rs66887589 0.837 rs7661498 chr4:120408108 T/C cg25214090 chr10:38739885 LOC399744 0.41 6.44 0.33 4.27e-10 Diastolic blood pressure; CRC cis rs10504229 0.683 rs11785260 chr8:58132906 A/G cg02290350 chr8:58132656 NA -0.58 -8.16 -0.41 7.29e-15 Developmental language disorder (linguistic errors); CRC cis rs9858542 0.953 rs9837027 chr3:49597013 C/T cg00383909 chr3:49044727 WDR6 0.44 5.61 0.3 4.32e-8 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC trans rs7395662 0.709 rs11040113 chr11:48895653 G/A cg21153622 chr11:89784906 NA -0.49 -7.78 -0.39 9.36e-14 HDL cholesterol; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg01068452 chr8:53626947 RB1CC1 0.37 6.11 0.32 2.79e-9 Liver disease severity in Alagille syndrome; CRC cis rs6429082 0.633 rs1416473 chr1:235563259 C/T cg26050004 chr1:235667680 B3GALNT2 -0.44 -5.69 -0.3 2.87e-8 Adiposity; CRC trans rs17783634 0.509 rs11775489 chr8:11036843 T/C cg16141378 chr3:129829833 LOC729375 0.43 6.17 0.32 1.96e-9 Subjective well-being; CRC cis rs6502050 0.799 rs6502078 chr17:80124364 G/A cg09264619 chr17:80180166 NA -0.35 -5.93 -0.31 7.47e-9 Life satisfaction; CRC cis rs9325144 0.560 rs12424821 chr12:38649951 C/T cg26384229 chr12:38710491 ALG10B -0.56 -8.38 -0.42 1.54e-15 Morning vs. evening chronotype; CRC cis rs13256369 1.000 rs7843488 chr8:8576217 C/T cg18904891 chr8:8559673 CLDN23 0.52 6.83 0.35 4.14e-11 Obesity-related traits; CRC cis rs9549367 0.789 rs9549365 chr13:113907391 C/T cg00898013 chr13:113819073 PROZ 0.43 6.04 0.32 4.26e-9 Platelet distribution width; CRC cis rs924607 1.000 rs11746907 chr5:598224 G/A cg04476341 chr5:669733 TPPP -0.43 -7.0 -0.36 1.48e-11 Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia; CRC cis rs12188164 1.000 rs56042615 chr5:437667 G/A cg21972741 chr5:435613 AHRR 0.53 7.37 0.38 1.41e-12 Cystic fibrosis severity; CRC cis rs853679 0.517 rs9380049 chr6:28048535 A/G cg02683197 chr6:28174875 NA 0.79 9.73 0.47 8.12e-20 Depression; CRC cis rs3736485 0.966 rs2414110 chr15:51901302 T/C cg08986416 chr15:51914746 DMXL2 -0.46 -6.51 -0.34 2.86e-10 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs11577318 0.853 rs12728971 chr1:26626612 C/T cg04990556 chr1:26633338 UBXN11 -0.48 -6.15 -0.32 2.31e-9 Granulocyte percentage of myeloid white cells; CRC cis rs12477438 0.561 rs2084988 chr2:99655755 T/C cg26064155 chr2:99771622 LIPT1;TSGA10 -0.63 -8.55 -0.43 4.61e-16 Chronic sinus infection; CRC cis rs514406 0.858 rs574853 chr1:53310959 A/T cg25767906 chr1:53392781 SCP2 -0.45 -7.19 -0.37 4.39e-12 Monocyte count; CRC cis rs6952808 1.000 rs4256490 chr7:1890764 G/A cg04267008 chr7:1944627 MAD1L1 -0.77 -11.02 -0.52 2.97e-24 Bipolar disorder and schizophrenia; CRC cis rs453301 0.506 rs686189 chr8:8623637 A/G cg06636001 chr8:8085503 FLJ10661 -0.47 -7.03 -0.36 1.24e-11 Joint mobility (Beighton score); CRC cis rs8060686 0.844 rs7196076 chr16:67887494 T/A cg06138825 chr16:67683817 RLTPR -0.54 -5.64 -0.3 3.61e-8 HDL cholesterol;Metabolic syndrome; CRC cis rs736408 0.677 rs1042779 chr3:52821011 A/G cg15147215 chr3:52552868 STAB1 -0.58 -9.65 -0.47 1.49e-19 Bipolar disorder; CRC cis rs1707322 0.752 rs11488313 chr1:46224780 G/C cg06784218 chr1:46089804 CCDC17 0.65 12.1 0.56 3.88e-28 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs1577917 1.000 rs2166663 chr6:86593896 G/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.51 -6.88 -0.35 3.05e-11 Response to antipsychotic treatment; CRC cis rs3862030 0.503 rs6584506 chr10:104254428 T/C cg04362960 chr10:104952993 NT5C2 -0.43 -6.1 -0.32 2.92e-9 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for body mass index; CRC cis rs7772486 0.686 rs2328708 chr6:146095739 G/A cg13319975 chr6:146136371 FBXO30 0.43 6.48 0.34 3.38e-10 Lobe attachment (rater-scored or self-reported); CRC cis rs12410462 0.681 rs6682883 chr1:227635598 G/A cg23173402 chr1:227635558 NA 0.88 9.24 0.45 3.09e-18 Major depressive disorder; CRC cis rs853679 0.517 rs17711344 chr6:28077602 A/G cg12172441 chr6:28176163 NA -0.67 -8.12 -0.41 9.7e-15 Depression; CRC cis rs17270561 0.609 rs12529272 chr6:25731342 A/G cg17691542 chr6:26056736 HIST1H1C 0.73 9.26 0.45 2.71e-18 Iron status biomarkers; CRC cis rs12348691 0.503 rs7048394 chr9:100605433 T/C cg13688889 chr9:100608707 NA -0.47 -6.03 -0.32 4.44e-9 Alopecia areata; CRC cis rs780096 0.526 rs2911713 chr2:27640980 G/A cg21248554 chr2:27665150 KRTCAP3 -0.31 -7.23 -0.37 3.41e-12 Total body bone mineral density; CRC cis rs6912958 0.559 rs242280 chr6:88048714 G/A cg04972856 chr6:88032051 C6orf162;GJB7 0.31 5.81 0.3 1.5e-8 Monocyte percentage of white cells; CRC cis rs2576037 0.526 rs7240239 chr18:44460037 T/C cg19077165 chr18:44547161 KATNAL2 -0.6 -10.17 -0.49 2.72e-21 Personality dimensions; CRC cis rs9837602 0.935 rs4928149 chr3:99685686 A/T cg07805332 chr3:99536008 MIR548G;C3orf26 0.48 6.11 0.32 2.83e-9 Breast cancer; CRC cis rs8141529 0.732 rs5752798 chr22:29181868 A/G cg15103426 chr22:29168792 CCDC117 0.61 8.84 0.44 5.88e-17 Lymphocyte counts; CRC cis rs9611565 0.659 rs12484228 chr22:41939739 A/G cg06481639 chr22:41940642 POLR3H -0.5 -5.8 -0.3 1.53e-8 Vitiligo; CRC cis rs12451471 0.500 rs8077056 chr17:78076006 C/T cg18972013 chr17:78078605 GAA -0.39 -5.71 -0.3 2.53e-8 Plateletcrit;Mean corpuscular hemoglobin concentration; CRC cis rs1129187 0.755 rs7760250 chr6:42929839 G/A cg10862848 chr6:42927986 GNMT -0.38 -9.19 -0.45 4.44e-18 Alzheimer's disease in APOE e4+ carriers; CRC cis rs6062302 0.549 rs4809586 chr20:62249402 C/T cg09650180 chr20:62225654 GMEB2 -0.51 -6.74 -0.35 7.21e-11 Glioblastoma; CRC cis rs6951245 0.554 rs11544331 chr7:1131411 C/T cg21664854 chr7:1097933 C7orf50;GPR146 0.57 7.09 0.36 8.49e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs13108904 0.539 rs13140926 chr4:1340939 G/A cg21620606 chr4:1342894 KIAA1530 0.51 8.03 0.4 1.77e-14 Obesity-related traits; CRC cis rs7605827 0.930 rs7590340 chr2:15601441 C/T cg19274914 chr2:15703543 NA 0.4 6.09 0.32 3.23e-9 Educational attainment (years of education); CRC cis rs7586879 0.639 rs6545776 chr2:25099357 A/C cg04586622 chr2:25135609 ADCY3 -0.57 -10.66 -0.51 5.62e-23 Body mass index; CRC cis rs7552404 0.590 rs1565717 chr1:76320441 T/C cg03433033 chr1:76189801 ACADM -0.69 -9.29 -0.46 2.12e-18 Blood metabolite levels;Acylcarnitine levels; CRC cis rs5753618 0.561 rs2073857 chr22:31658281 A/G cg22777020 chr22:31556080 RNF185 -0.52 -5.97 -0.31 6.27e-9 Colorectal cancer; CRC cis rs7539542 0.516 rs10732291 chr1:202891168 G/A cg19681188 chr1:202830198 LOC148709 0.45 6.49 0.34 3.24e-10 Mean platelet volume; CRC cis rs12291225 0.585 rs10832246 chr11:14380828 G/A cg05501817 chr11:14380813 RRAS2 -0.47 -6.55 -0.34 2.19e-10 Sense of smell; CRC cis rs7769051 1.000 rs9493443 chr6:133121349 C/T cg22852734 chr6:133119734 C6orf192 0.99 12.36 0.56 4.3e-29 Type 2 diabetes nephropathy; CRC cis rs7618915 0.524 rs35249778 chr3:52661640 G/C cg11645453 chr3:52864694 ITIH4 0.35 6.17 0.32 2e-9 Bipolar disorder; CRC cis rs34375054 0.738 rs10773145 chr12:125625603 C/T cg05341575 chr12:125625032 AACS 0.34 5.78 0.3 1.76e-8 Post bronchodilator FEV1/FVC ratio; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg12624087 chr22:32341561 C22orf24;YWHAH 0.45 6.27 0.33 1.15e-9 Response to antipsychotic treatment; CRC cis rs10256972 0.758 rs7799391 chr7:1082566 C/G cg07308232 chr7:1071921 C7orf50 -0.51 -7.25 -0.37 2.97e-12 Longevity;Endometriosis; CRC cis rs1862618 0.853 rs832553 chr5:56114786 A/G cg18230493 chr5:56204884 C5orf35 -0.71 -9.24 -0.45 3.05e-18 Initial pursuit acceleration; CRC cis rs6951245 1.000 rs74652290 chr7:1090109 G/A cg18402987 chr7:1209562 NA 0.6 6.48 0.34 3.35e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs6060717 0.536 rs6060664 chr20:34478884 T/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.5 -5.99 -0.31 5.58e-9 Hip circumference adjusted for BMI; CRC cis rs9611565 0.659 rs12483998 chr22:41935362 A/G cg06481639 chr22:41940642 POLR3H -0.54 -6.11 -0.32 2.81e-9 Vitiligo; CRC cis rs801193 0.569 rs7782587 chr7:66166472 C/T cg11764359 chr7:65958608 NA 0.59 8.77 0.44 9.79e-17 Aortic root size; CRC trans rs10842750 1.000 rs10842750 chr12:26690565 G/T cg04342092 chr19:58095468 ZIK1 0.31 6.06 0.32 3.77e-9 Kashin-Beck disease; CRC cis rs7845219 0.597 rs7002058 chr8:95873993 G/C cg16049864 chr8:95962084 TP53INP1 -0.54 -9.18 -0.45 4.97e-18 Type 2 diabetes; CRC cis rs9311474 0.597 rs6778735 chr3:52565100 T/C cg10802521 chr3:52805072 NEK4 -0.4 -6.24 -0.33 1.37e-9 Electroencephalogram traits; CRC cis rs9611519 0.780 rs5751071 chr22:41656332 G/A cg03806693 chr22:41940476 POLR3H -0.58 -8.06 -0.41 1.46e-14 Neuroticism; CRC cis rs7246657 0.943 rs7258692 chr19:37818829 C/A cg23950597 chr19:37808831 NA -0.52 -6.09 -0.32 3.19e-9 Coronary artery calcification; CRC cis rs10463316 0.817 rs730526 chr5:150789232 A/G cg03212797 chr5:150827313 SLC36A1 -0.44 -6.77 -0.35 5.81e-11 Metabolite levels (Pyroglutamine); CRC cis rs6860806 1.000 rs6860806 chr5:131640536 C/T cg11843238 chr5:131593191 PDLIM4 -0.37 -7.12 -0.37 6.96e-12 Breast cancer; CRC cis rs4713118 0.513 rs9368547 chr6:28028067 A/G cg25164649 chr6:28176230 NA 0.59 8.24 0.41 4.21e-15 Parkinson's disease; CRC cis rs17270561 0.887 rs9358870 chr6:25719210 T/C cg16482183 chr6:26056742 HIST1H1C 0.73 7.98 0.4 2.53e-14 Iron status biomarkers; CRC cis rs8126001 0.573 rs6090043 chr20:62717930 C/T cg03642690 chr20:62727907 OPRL1 -0.38 -5.95 -0.31 6.86e-9 Pulse pressure;Mean corpuscular volume; CRC cis rs12477438 0.798 rs10202452 chr2:99569409 T/C cg14399236 chr2:99771627 LIPT1;TSGA10 -0.69 -9.69 -0.47 1.03e-19 Chronic sinus infection; CRC cis rs149866169 1 rs149866169 chr6:27441723 T/A cg21204522 chr6:27730016 NA -0.68 -5.97 -0.31 6.08e-9 Neuroticism (multi-trait analysis);Lung cancer in ever smokers;Subjective well-being (multi-trait analysis);Lung cancer;Squamous cell lung carcinoma; CRC cis rs1003719 0.715 rs58008706 chr21:38540506 A/G cg10648535 chr21:38446584 PIGP;TTC3 -0.48 -6.55 -0.34 2.25e-10 Eye color traits; CRC cis rs9372498 0.536 rs62424172 chr6:118777533 C/A cg10217327 chr6:118973057 C6orf204 0.51 5.76 0.3 1.93e-8 Diastolic blood pressure; CRC cis rs1153858 1.000 rs11852800 chr15:45639131 A/G cg10760299 chr15:45669010 GATM -0.48 -7.79 -0.39 8.74e-14 Homoarginine levels; CRC cis rs7835763 0.692 rs6988721 chr8:119104040 G/A cg11592677 chr8:119110466 EXT1 -0.38 -6.18 -0.32 1.93e-9 Autism spectrum disorder; CRC cis rs910316 0.967 rs175498 chr14:75536369 G/A cg03030879 chr14:75389066 RPS6KL1 0.46 7.23 0.37 3.41e-12 Height; CRC cis rs9816226 0.938 rs55742087 chr3:185830488 C/T cg00760338 chr3:185826511 ETV5 -0.71 -7.74 -0.39 1.21e-13 Obesity;Body mass index; CRC cis rs13191362 1.000 rs35911566 chr6:162994154 T/C cg21926612 chr6:163149169 PACRG;PARK2 0.82 11.49 0.54 6.51e-26 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs4665809 0.556 rs10221814 chr2:26442759 C/T cg26119090 chr2:26468346 HADHA;HADHB -1.0 -14.65 -0.63 8.89e-38 Gut microbiome composition (summer); CRC cis rs35306767 0.761 rs12771539 chr10:1050653 A/G cg20503657 chr10:835505 NA 0.93 11.11 0.52 1.43e-24 Eosinophil percentage of granulocytes; CRC cis rs9916302 0.706 rs590051 chr17:37446571 T/C cg00129232 chr17:37814104 STARD3 0.59 7.39 0.38 1.24e-12 Glomerular filtration rate (creatinine); CRC cis rs6674176 0.628 rs3791116 chr1:44414156 T/A cg12908607 chr1:44402522 ARTN -0.51 -9.13 -0.45 7.33e-18 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Cognitive ability; CRC cis rs514406 0.755 rs10888754 chr1:53228751 C/G cg25767906 chr1:53392781 SCP2 0.4 6.48 0.34 3.38e-10 Monocyte count; CRC cis rs3101457 0.530 rs9782996 chr1:244528127 C/T cg09033006 chr1:244517177 C1orf100 0.41 5.98 0.31 5.72e-9 Smoking behavior; CRC cis rs6502050 0.764 rs28676462 chr17:80105100 G/C cg19223190 chr17:80058835 NA 0.4 6.36 0.33 6.88e-10 Life satisfaction; CRC cis rs9910055 0.529 rs183462 chr17:42183376 G/C cg09913183 chr17:42254507 C17orf65;ASB16 -0.48 -6.54 -0.34 2.36e-10 Total body bone mineral density; CRC cis rs2996428 0.667 rs11578070 chr1:3769871 G/C cg13057898 chr1:3703894 LRRC47 0.53 7.03 0.36 1.21e-11 Red cell distribution width; CRC cis rs3820068 0.581 rs61056912 chr1:15926296 A/G cg24675056 chr1:15929824 NA 0.51 7.17 0.37 5.04e-12 Systolic blood pressure; CRC cis rs4332037 0.539 rs868754 chr7:2033780 G/C cg25834613 chr7:1915315 MAD1L1 -0.49 -6.59 -0.34 1.77e-10 Bipolar disorder; CRC cis rs9322193 0.923 rs2184369 chr6:150097817 G/A cg07701084 chr6:150067640 NUP43 0.47 6.61 0.34 1.51e-10 Lung cancer; CRC cis rs921968 0.565 rs6436073 chr2:219618237 A/C cg02176678 chr2:219576539 TTLL4 -0.43 -6.85 -0.35 3.55e-11 Mean corpuscular hemoglobin concentration; CRC cis rs9916302 0.752 rs9901219 chr17:37558369 T/G cg03013999 chr17:37608204 MED1 -0.45 -6.33 -0.33 8e-10 Glomerular filtration rate (creatinine); CRC cis rs208515 0.525 rs12214310 chr6:66666308 A/G cg07460842 chr6:66804631 NA 0.94 11.82 0.55 4.02e-27 Exhaled nitric oxide levels; CRC cis rs311392 0.902 rs2666874 chr8:55091561 A/T cg06042504 chr8:55087323 NA 0.43 6.69 0.35 9.39e-11 Pelvic organ prolapse (moderate/severe); CRC trans rs4130344 0.555 rs7664704 chr4:159866176 A/G cg04008429 chr3:160167646 TRIM59 0.41 6.0 0.31 5.34e-9 Intelligence (multi-trait analysis); CRC cis rs7618915 0.501 rs6617 chr3:52740182 C/G cg18099408 chr3:52552593 STAB1 -0.45 -7.49 -0.38 6.26e-13 Bipolar disorder; CRC cis rs853679 0.542 rs2295594 chr6:28053097 G/A cg15786705 chr6:28176104 NA 0.74 9.47 0.46 5.74e-19 Depression; CRC cis rs873946 0.564 rs2803991 chr10:134557068 A/G cg06453172 chr10:134556979 INPP5A -0.67 -9.03 -0.45 1.44e-17 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CRC cis rs1639906 0.965 rs1639909 chr7:2233045 A/C cg19897017 chr7:2163380 MAD1L1 0.41 6.14 0.32 2.43e-9 Colonoscopy-negative controls vs population controls; CRC cis rs6831352 0.918 rs17217949 chr4:100054312 A/G cg13256891 chr4:100009986 ADH5 -0.66 -8.89 -0.44 4.04e-17 Alcohol dependence; CRC cis rs6570726 0.967 rs418662 chr6:145848832 A/C cg23711669 chr6:146136114 FBXO30 0.63 10.67 0.51 5.21e-23 Lobe attachment (rater-scored or self-reported); CRC cis rs11758351 0.715 rs76130408 chr6:26208962 A/G cg08260959 chr6:26240920 HIST1H4F -0.36 -5.74 -0.3 2.16e-8 Gout;Renal underexcretion gout; CRC cis rs2708977 0.933 rs2464914 chr2:97179828 A/G cg01950434 chr2:97203154 ARID5A -0.44 -6.54 -0.34 2.32e-10 Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes; CRC cis rs1712517 1.000 rs1712517 chr10:105033015 C/T cg05636881 chr10:105038444 INA 0.46 8.2 0.41 5.35e-15 Migraine; CRC cis rs8081692 1 rs8081692 chr17:38154595 A/G cg17344932 chr17:38183730 MED24;SNORD124 -0.45 -6.98 -0.36 1.61e-11 Neutrophil count; CRC cis rs4970988 0.556 rs6695123 chr1:150563483 T/C cg10589385 chr1:150898437 SETDB1 -0.31 -6.48 -0.34 3.26e-10 Urate levels; CRC cis rs4664308 0.594 rs4665141 chr2:160890795 A/T cg03641300 chr2:160917029 PLA2R1 -0.55 -8.39 -0.42 1.48e-15 Idiopathic membranous nephropathy; CRC cis rs11758351 0.517 rs79958315 chr6:26221826 C/T cg08260959 chr6:26240920 HIST1H4F -0.36 -5.98 -0.31 5.68e-9 Gout;Renal underexcretion gout; CRC cis rs939584 0.935 rs13022164 chr2:632536 A/G cg03610516 chr2:642275 NA 0.42 5.64 0.3 3.58e-8 Body mass index; CRC trans rs853679 0.546 rs200989 chr6:27816442 A/G cg16898833 chr6:26189333 HIST1H4D 0.72 6.46 0.34 3.75e-10 Depression; CRC cis rs6840360 0.642 rs2724578 chr4:152367304 A/G cg09659197 chr4:152720779 NA 0.33 6.61 0.34 1.57e-10 Intelligence (multi-trait analysis); CRC cis rs10155981 0.510 rs4722159 chr7:22584279 C/G cg05062323 chr7:22590069 NA -0.62 -7.14 -0.37 6.02e-12 Bilirubin levels; CRC cis rs11971779 0.700 rs11763942 chr7:139005795 A/T cg07862535 chr7:139043722 LUC7L2 0.75 8.51 0.42 6.38e-16 Diisocyanate-induced asthma; CRC cis rs208520 0.874 rs208512 chr6:66943869 C/G cg07460842 chr6:66804631 NA -0.95 -12.39 -0.56 3.35e-29 Exhaled nitric oxide output; CRC cis rs977987 0.931 rs7195161 chr16:75495572 T/C cg03315344 chr16:75512273 CHST6 0.6 10.17 0.49 2.69e-21 Dupuytren's disease; CRC cis rs72781680 0.950 rs72796343 chr2:24147631 G/A cg08917208 chr2:24149416 ATAD2B 1.03 10.1 0.49 4.66e-21 Lymphocyte counts; CRC cis rs17818399 0.788 rs13013245 chr2:46806086 T/C cg26688816 chr2:46740690 ATP6V1E2 -0.46 -6.09 -0.32 3.2e-9 Height; CRC cis rs932541 1.000 rs6111153 chr20:16456113 C/T cg17003395 chr20:16555519 KIF16B 0.41 5.63 0.3 3.82e-8 Intelligence; CRC cis rs875971 0.929 rs10950041 chr7:65973875 T/C cg18876405 chr7:65276391 NA 0.51 8.78 0.44 9.39e-17 Aortic root size; CRC trans rs35094601 0.918 rs13020860 chr2:139214346 C/T cg25299176 chr17:1303341 YWHAE -0.47 -6.7 -0.35 9.16e-11 Schizophrenia; CRC cis rs7089973 0.604 rs7095816 chr10:116585109 T/C cg23260525 chr10:116636907 FAM160B1 0.39 9.22 0.45 3.67e-18 Bipolar disorder or attention deficit hyperactivity disorder; CRC cis rs7572644 0.699 rs898032 chr2:28202936 C/G cg27432699 chr2:27873401 GPN1 -0.4 -5.61 -0.3 4.22e-8 Response to carboplatin and paclitaxel in ovarian cancer (Caspase 3/7 EC50); CRC cis rs9486715 0.809 rs9486467 chr6:96971803 C/T cg18709589 chr6:96969512 KIAA0776 0.5 7.45 0.38 8.24e-13 Headache; CRC cis rs1799949 1.000 rs1135214 chr17:41292323 T/C cg25072359 chr17:41440525 NA 0.44 6.42 0.33 4.86e-10 Menopause (age at onset); CRC cis rs2239547 0.522 rs2581797 chr3:52972468 C/T cg18404041 chr3:52824283 ITIH1 0.33 6.55 0.34 2.26e-10 Schizophrenia; CRC cis rs2457480 0.516 rs10899989 chr10:44640048 C/T cg09554077 chr10:44749378 NA 0.47 6.08 0.32 3.27e-9 Coronary artery disease; CRC cis rs769267 0.598 rs8108705 chr19:19675367 G/T cg03709012 chr19:19516395 GATAD2A -0.53 -7.17 -0.37 4.93e-12 Tonsillectomy; CRC trans rs2014572 0.967 rs11084492 chr19:57756026 A/T cg02674126 chr19:40336878 FBL 0.43 6.91 0.36 2.58e-11 Hyperactive-impulsive symptoms; CRC cis rs753274 0.650 rs28497965 chr19:14417402 T/G cg25450033 chr19:14444658 NA 0.34 5.94 0.31 7.37e-9 Tumor necrosis factor beta levels; CRC cis rs7811142 0.943 rs67483801 chr7:100031758 G/T cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.75 10.81 0.51 1.64e-23 Platelet count; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg10981541 chr17:636487 FAM57A 0.37 6.33 0.33 7.81e-10 Response to antipsychotic treatment; CRC cis rs8058578 0.832 rs7500719 chr16:30840877 C/T cg00531865 chr16:30841666 NA -0.48 -6.49 -0.34 3.13e-10 Multiple myeloma; CRC cis rs2290405 0.527 rs7663192 chr4:923947 T/C cg04045327 chr4:905805 GAK -0.48 -8.2 -0.41 5.4e-15 Systemic sclerosis; CRC cis rs2249625 0.584 rs2496506 chr6:72891324 A/C cg18830697 chr6:72922368 RIMS1 -0.4 -7.99 -0.4 2.31e-14 Acute urticaria and angioedema (non-steroidal anti-inflammatory drug-induced); CRC cis rs17767392 0.881 rs67489015 chr14:71964521 G/A cg13720639 chr14:72061746 SIPA1L1 -0.57 -7.28 -0.37 2.49e-12 Mitral valve prolapse; CRC cis rs919433 0.963 rs12617117 chr2:198155170 T/A cg03934865 chr2:198174659 NA -0.47 -7.36 -0.38 1.47e-12 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC cis rs3204270 0.673 rs62077190 chr17:79676109 C/A cg09655341 chr17:79618100 PDE6G 0.63 7.2 0.37 4.24e-12 Dental caries; CRC cis rs8180040 0.966 rs7649234 chr3:47494380 G/C cg10298567 chr3:47292165 KIF9 -0.36 -5.91 -0.31 8.46e-9 Colorectal cancer; CRC trans rs6847067 0.800 rs11097026 chr4:85803607 G/T cg24769924 chr12:32553033 NA -0.38 -6.1 -0.32 3.01e-9 Oropharynx cancer; CRC cis rs1008375 0.931 rs2315558 chr4:17674558 C/A cg16339924 chr4:17578868 LAP3 0.48 6.14 0.32 2.41e-9 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs10256972 0.591 rs10229680 chr7:1158565 C/T cg07308232 chr7:1071921 C7orf50 -0.45 -5.9 -0.31 9.16e-9 Longevity;Endometriosis; CRC cis rs17401966 0.931 rs3748579 chr1:10420937 C/T cg19773385 chr1:10388646 KIF1B -0.68 -10.98 -0.52 4.16e-24 Hepatocellular carcinoma; CRC cis rs2991971 0.810 rs781058 chr1:45935056 C/G cg15605315 chr1:45957053 TESK2 -0.35 -5.67 -0.3 3.08e-8 High light scatter reticulocyte count; CRC cis rs9660180 0.967 rs12044597 chr1:1708801 A/G cg23982607 chr1:1823379 GNB1 -0.87 -15.73 -0.66 5.75e-42 Body mass index; CRC cis rs7666738 0.830 rs17027216 chr4:99009152 G/C cg05340658 chr4:99064831 C4orf37 0.61 9.54 0.47 3.44e-19 Colonoscopy-negative controls vs population controls; CRC cis rs8180040 0.681 rs9818382 chr3:47193034 C/T cg27129171 chr3:47204927 SETD2 0.72 11.38 0.53 1.64e-25 Colorectal cancer; CRC trans rs7267979 0.816 rs6138593 chr20:25504492 A/G cg17903999 chr18:56338584 MALT1 -0.39 -6.45 -0.34 4.08e-10 Liver enzyme levels (alkaline phosphatase); CRC cis rs72781680 0.948 rs113530757 chr2:24142500 G/A cg08917208 chr2:24149416 ATAD2B 0.91 9.24 0.45 3.06e-18 Lymphocyte counts; CRC cis rs9733 0.566 rs72702554 chr1:150678234 A/G cg18016565 chr1:150552671 MCL1 0.46 6.63 0.34 1.39e-10 Tonsillectomy; CRC cis rs807669 0.525 rs2282684 chr22:19184244 C/T cg02655711 chr22:19163373 SLC25A1 0.54 8.7 0.43 1.62e-16 Metabolite levels; CRC cis rs2004318 1.000 rs2781760 chr19:55140609 C/T cg03320607 chr19:54800032 LILRA3 -0.65 -5.69 -0.3 2.82e-8 Blood protein levels; CRC cis rs6860806 0.661 rs28472559 chr5:131581611 G/A cg09877947 chr5:131593287 PDLIM4 0.43 8.05 0.41 1.57e-14 Breast cancer; CRC cis rs6693567 0.565 rs834242 chr1:150379858 G/A cg15654264 chr1:150340011 RPRD2 0.39 5.98 0.31 5.73e-9 Migraine; CRC cis rs9733 0.818 rs4970926 chr1:150673684 T/C cg17724175 chr1:150552817 MCL1 -0.47 -7.39 -0.38 1.19e-12 Tonsillectomy; CRC cis rs832540 0.656 rs6862118 chr5:56106474 G/A cg20203395 chr5:56204925 C5orf35 -0.44 -6.03 -0.32 4.43e-9 Coronary artery disease; CRC trans rs35110281 0.633 rs4819289 chr21:45120237 A/G cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.41 6.57 0.34 2e-10 Mean corpuscular volume; CRC cis rs9372498 0.536 rs55697388 chr6:118891544 C/T cg15382696 chr6:118971807 C6orf204 0.6 7.65 0.39 2.19e-13 Diastolic blood pressure; CRC cis rs2739330 0.760 rs1002286 chr22:24257337 A/G cg11060661 chr22:24314208 DDT;DDTL -0.5 -8.98 -0.44 2.11e-17 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs6502050 0.799 rs11491185 chr17:80151101 C/T cg19223190 chr17:80058835 NA 0.39 6.21 0.32 1.62e-9 Life satisfaction; CRC cis rs7412746 0.658 rs4970982 chr1:150865084 G/C cg18016565 chr1:150552671 MCL1 0.41 5.78 0.3 1.73e-8 Melanoma; CRC cis rs11105298 0.786 rs10858867 chr12:89851166 C/T cg08166232 chr12:89918718 WDR51B;GALNT4 -0.61 -7.77 -0.39 1.01e-13 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; CRC cis rs2204008 0.774 rs10400552 chr12:38393577 C/G cg13010199 chr12:38710504 ALG10B 0.46 6.21 0.32 1.55e-9 Bladder cancer; CRC cis rs7771547 0.573 rs584418 chr6:36395437 G/A cg07856975 chr6:36356162 ETV7 0.4 5.85 0.31 1.19e-8 Platelet distribution width; CRC cis rs7094131 0.523 rs10741008 chr10:22882344 T/G cg19500236 chr10:22911537 PIP4K2A 0.36 5.63 0.3 3.93e-8 Obesity-related traits; CRC cis rs6479527 0.904 rs7867925 chr9:96857990 G/A cg14459158 chr9:96720562 NA 0.43 7.38 0.38 1.31e-12 Esophageal adenocarcinoma; CRC cis rs2692947 0.666 rs10183151 chr2:96774786 T/G cg23100626 chr2:96804247 ASTL -0.25 -6.66 -0.34 1.17e-10 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; CRC cis rs3849570 1.000 rs9817181 chr3:81827765 A/C cg07356753 chr3:81810745 GBE1 -0.73 -11.05 -0.52 2.34e-24 Waist circumference;Body mass index; CRC cis rs57221529 0.766 rs12519763 chr5:559145 C/T cg09021430 chr5:549028 NA -0.72 -8.17 -0.41 6.5e-15 Lung disease severity in cystic fibrosis; CRC cis rs4363385 0.747 rs4845333 chr1:152982877 G/T cg25856811 chr1:152973957 SPRR3 -0.25 -6.85 -0.35 3.56e-11 Inflammatory skin disease; CRC trans rs2303319 0.504 rs16845960 chr2:162501613 A/G cg18122310 chr12:50236657 BCDIN3D -0.74 -6.19 -0.32 1.81e-9 Cognitive function; CRC cis rs12477438 0.520 rs11695751 chr2:99708247 A/C cg26064155 chr2:99771622 LIPT1;TSGA10 0.9 16.76 0.68 5.2e-46 Chronic sinus infection; CRC cis rs965469 0.947 rs965470 chr20:3381588 C/G cg25506879 chr20:3388711 C20orf194 -0.4 -5.9 -0.31 9.05e-9 IFN-related cytopenia; CRC trans rs7267979 1.000 rs6076336 chr20:25319212 C/T cg17903999 chr18:56338584 MALT1 0.42 6.91 0.36 2.48e-11 Liver enzyme levels (alkaline phosphatase); CRC cis rs2120019 0.938 rs1867150 chr15:75321139 T/C cg09165964 chr15:75287851 SCAMP5 -0.86 -13.39 -0.59 5.93e-33 Blood trace element (Zn levels); CRC cis rs8062405 0.929 rs11150609 chr16:28870596 A/G cg16576597 chr16:28551801 NUPR1 0.48 6.83 0.35 4.14e-11 Cognitive ability (multi-trait analysis);Cognitive ability; CRC cis rs9902453 0.817 rs55974138 chr17:28215546 A/G cg26525008 chr17:28256777 EFCAB5;SSH2 0.57 8.62 0.43 2.93e-16 Coffee consumption (cups per day); CRC cis rs10751667 0.666 rs10794347 chr11:939863 G/A cg06064525 chr11:970664 AP2A2 -0.31 -6.16 -0.32 2.18e-9 Alzheimer's disease (late onset); CRC cis rs2708977 0.933 rs2579502 chr2:97198800 A/G cg01950434 chr2:97203154 ARID5A -0.47 -7.01 -0.36 1.33e-11 Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes; CRC cis rs2735413 0.881 rs4888727 chr16:78077038 T/C cg04733911 chr16:78082701 NA -0.45 -7.5 -0.38 6.09e-13 Systolic blood pressure (alcohol consumption interaction); CRC cis rs514406 0.683 rs10157120 chr1:53210888 A/G cg27535305 chr1:53392650 SCP2 -0.34 -6.1 -0.32 2.98e-9 Monocyte count; CRC cis rs6831352 0.918 rs29001202 chr4:100053782 T/A cg12011299 chr4:100065546 ADH4 -0.49 -9.25 -0.45 3.02e-18 Alcohol dependence; CRC cis rs2274273 0.840 rs7159144 chr14:55821324 G/A cg23234261 chr14:55582407 NA -0.29 -5.89 -0.31 9.3e-9 Protein biomarker; CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg02891801 chr12:6472782 SCNN1A -0.56 -6.81 -0.35 4.65e-11 Diisocyanate-induced asthma; CRC cis rs908922 0.676 rs6687126 chr1:152530894 T/G cg09873164 chr1:152488093 CRCT1 0.36 6.16 0.32 2.14e-9 Hair morphology; CRC trans rs9929218 0.954 rs12919719 chr16:68822341 C/G cg04657470 chr2:198365150 HSPE1;HSPD1 -0.75 -10.62 -0.51 7.43e-23 Colorectal cancer; CRC cis rs7772486 0.720 rs4896844 chr6:146075224 T/C cg23711669 chr6:146136114 FBXO30 -0.75 -12.86 -0.58 6.07e-31 Lobe attachment (rater-scored or self-reported); CRC cis rs10504229 1.000 rs113379801 chr8:58173686 C/G cg01721255 chr8:58191610 C8orf71 0.47 6.02 0.31 4.74e-9 Developmental language disorder (linguistic errors); CRC cis rs13315871 0.929 rs13082278 chr3:58318224 A/G cg20936604 chr3:58311152 NA -0.75 -7.68 -0.39 1.87e-13 Cholesterol, total; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg15279766 chr6:26402511 BTN3A1 0.45 6.55 0.34 2.28e-10 Response to antipsychotic treatment; CRC cis rs10256972 0.568 rs1133043 chr7:1133305 C/G cg23708337 chr7:1209742 NA 0.41 6.09 0.32 3.16e-9 Longevity;Endometriosis; CRC cis rs10256972 0.577 rs6962809 chr7:1208889 A/G cg23978390 chr7:1156363 C7orf50 0.47 6.45 0.34 3.94e-10 Longevity;Endometriosis; CRC cis rs9549367 0.789 rs2287250 chr13:113889474 C/T cg18105134 chr13:113819100 PROZ 0.74 11.62 0.54 2.1e-26 Platelet distribution width; CRC cis rs972578 0.868 rs2413727 chr22:43292114 A/G cg01576275 chr22:43409880 NA -0.42 -6.57 -0.34 1.93e-10 Mean platelet volume; CRC cis rs7618915 0.508 rs12498066 chr3:52627660 G/A cg10802521 chr3:52805072 NEK4 -0.59 -9.1 -0.45 8.89e-18 Bipolar disorder; CRC cis rs7264396 0.943 rs224395 chr20:34109427 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.42 -6.97 -0.36 1.75e-11 Total cholesterol levels; CRC cis rs875971 0.662 rs448725 chr7:65514628 A/G cg00343986 chr7:65444356 GUSB 0.47 6.96 0.36 1.81e-11 Aortic root size; CRC cis rs7618915 0.547 rs2289250 chr3:52682946 A/C cg07507251 chr3:52567010 NT5DC2 -0.43 -6.2 -0.32 1.68e-9 Bipolar disorder; CRC cis rs875971 0.862 rs2024192 chr7:66041447 G/T cg11764359 chr7:65958608 NA -0.59 -8.87 -0.44 4.67e-17 Aortic root size; CRC cis rs2976388 0.609 rs2717603 chr8:143803193 T/C cg24046110 chr8:143859143 LYNX1 0.48 8.32 0.42 2.3e-15 Urinary tract infection frequency; CRC cis rs6540556 0.769 rs627670 chr1:209929299 G/A cg23920097 chr1:209922102 NA 0.55 6.73 0.35 7.61e-11 Red blood cell count; CRC cis rs10751667 0.666 rs7394958 chr11:965944 C/G cg01483505 chr11:975446 AP2A2 0.46 7.66 0.39 2.11e-13 Alzheimer's disease (late onset); CRC cis rs4481887 1.000 rs4360555 chr1:248468591 G/T cg13385794 chr1:248469461 NA 0.38 6.8 0.35 5.07e-11 Common traits (Other); CRC cis rs9322193 0.962 rs2342861 chr6:150098697 C/T cg07701084 chr6:150067640 NUP43 0.47 6.61 0.34 1.51e-10 Lung cancer; CRC cis rs599083 0.530 rs2472415 chr11:68185616 T/C cg16797656 chr11:68205561 LRP5 -0.41 -6.45 -0.33 4.04e-10 Bone mineral density (spine); CRC cis rs7072216 0.763 rs10748730 chr10:100171440 C/T cg26618903 chr10:100175079 PYROXD2 -0.55 -8.99 -0.44 2.03e-17 Metabolite levels; CRC cis rs929354 0.629 rs6950739 chr7:156982450 T/C cg17757837 chr7:157058334 UBE3C 0.74 12.53 0.57 1.03e-29 Body mass index; CRC cis rs344364 0.511 rs2982449 chr16:1947878 C/G cg03013636 chr16:1946785 NA 0.58 7.08 0.36 8.69e-12 Glomerular filtration rate in chronic kidney disease; CRC trans rs1814175 0.562 rs1794130 chr11:49903764 T/A cg03929089 chr4:120376271 NA -0.91 -16.07 -0.66 2.65e-43 Height; CRC cis rs780096 0.546 rs715326 chr2:27725761 A/G cg27432699 chr2:27873401 GPN1 0.54 8.27 0.41 3.34e-15 Total body bone mineral density; CRC cis rs2032447 0.670 rs198834 chr6:26114372 G/A cg12310025 chr6:25882481 NA 0.47 6.63 0.34 1.39e-10 Intelligence (multi-trait analysis); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg00369126 chr16:4674642 MGRN1 0.49 6.81 0.35 4.52e-11 Response to antipsychotic treatment; CRC cis rs9354308 0.840 rs17508021 chr6:66569748 G/A cg07460842 chr6:66804631 NA 0.47 5.92 0.31 8.03e-9 Metabolite levels; CRC cis rs2032447 0.670 rs71557318 chr6:26118570 T/C cg03517284 chr6:25882590 NA 0.41 5.66 0.3 3.3e-8 Intelligence (multi-trait analysis); CRC cis rs896854 0.625 rs7823886 chr8:95986459 A/T cg16049864 chr8:95962084 TP53INP1 -0.65 -11.43 -0.53 1.02e-25 Type 2 diabetes; CRC cis rs11630290 1.000 rs72750986 chr15:63996338 C/A cg12036633 chr15:63758958 NA -0.56 -5.81 -0.3 1.49e-8 Iris characteristics; CRC cis rs7089973 0.604 rs10885618 chr10:116617718 A/G cg23260525 chr10:116636907 FAM160B1 0.39 9.2 0.45 4.19e-18 Bipolar disorder or attention deficit hyperactivity disorder; CRC cis rs4065321 0.522 rs11078930 chr17:38141955 C/T cg17344932 chr17:38183730 MED24;SNORD124 0.86 16.84 0.68 2.51e-46 White blood cell count (basophil);White blood cell count; CRC cis rs10870270 0.913 rs4550 chr10:133781798 C/T cg17892150 chr10:133769511 PPP2R2D -0.75 -10.94 -0.52 5.62e-24 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg06350524 chr2:169747178 SPC25 0.41 6.59 0.34 1.72e-10 Liver disease severity in Alagille syndrome; CRC cis rs875971 0.862 rs28491091 chr7:65669064 G/T cg18252515 chr7:66147081 NA 0.41 5.72 0.3 2.34e-8 Aortic root size; CRC trans rs9914544 0.545 rs8071458 chr17:18790840 C/A cg21372672 chr17:16614065 CCDC144A -0.38 -6.1 -0.32 3e-9 Educational attainment (years of education); CRC cis rs9527 0.590 rs7910900 chr10:104829898 C/T cg04362960 chr10:104952993 NT5C2 0.57 8.05 0.41 1.57e-14 Arsenic metabolism; CRC cis rs6840360 0.642 rs2709820 chr4:152384039 A/G cg09659197 chr4:152720779 NA 0.34 6.7 0.35 9.13e-11 Intelligence (multi-trait analysis); CRC cis rs9372498 0.536 rs72969531 chr6:118729974 C/A cg01339444 chr6:118972232 C6orf204 0.52 5.82 0.31 1.41e-8 Diastolic blood pressure; CRC cis rs10479542 0.896 rs4701130 chr5:178982416 C/T cg00080972 chr5:178986291 RUFY1 -0.46 -9.09 -0.45 9.37e-18 Lung cancer; CRC cis rs950027 0.620 rs2461700 chr15:45640627 T/C cg21132104 chr15:45694354 SPATA5L1 0.42 6.21 0.32 1.61e-9 Response to fenofibrate (adiponectin levels); CRC trans rs1455244 0.700 rs7229302 chr18:11508904 G/T cg02506043 chr1:17765068 RCC2 0.45 6.87 0.35 3.18e-11 Schizophrenia; CRC cis rs801193 1.000 rs2659889 chr7:66217112 A/G cg25985355 chr7:65971099 NA -0.32 -5.61 -0.3 4.26e-8 Aortic root size; CRC cis rs7666738 0.830 rs13139024 chr4:99020700 C/T cg05340658 chr4:99064831 C4orf37 0.61 9.51 0.46 4.05e-19 Colonoscopy-negative controls vs population controls; CRC trans rs56037433 1 rs56037433 chr2:162575985 G/A cg01422129 chr2:677375 TMEM18 -0.75 -5.98 -0.31 5.77e-9 Bipolar disorder or attention deficit hyperactivity disorder; CRC cis rs10849893 0.595 rs7980819 chr12:121887194 A/G cg01154721 chr12:121881891 KDM2B -0.42 -6.03 -0.32 4.37e-9 Fasting blood glucose;Fasting blood glucose (BMI interaction); CRC cis rs6502050 0.842 rs7211808 chr17:80071244 T/C cg13198984 chr17:80129470 CCDC57 -0.47 -8.21 -0.41 5.25e-15 Life satisfaction; CRC cis rs35110281 0.782 rs1454651 chr21:45012476 A/G cg04455712 chr21:45112962 RRP1B 0.42 7.89 0.4 4.45e-14 Mean corpuscular volume; CRC cis rs765787 0.530 rs11855435 chr15:45522117 G/A cg24006582 chr15:45444508 DUOX1 -0.56 -8.55 -0.43 4.67e-16 Uric acid levels; CRC cis rs7731657 0.537 rs916818 chr5:130277673 G/C cg08523029 chr5:130500466 HINT1 0.43 5.71 0.3 2.49e-8 Fasting plasma glucose; CRC cis rs931127 0.505 rs2306362 chr11:65405510 G/T cg05805236 chr11:65401703 PCNXL3 -0.38 -5.84 -0.31 1.22e-8 Systemic lupus erythematosus; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg03641858 chr19:12777774 MORG1;MAN2B1 0.39 6.4 0.33 5.44e-10 Liver disease severity in Alagille syndrome; CRC cis rs6582630 0.555 rs11182217 chr12:38480030 G/A cg13010199 chr12:38710504 ALG10B 0.48 6.08 0.32 3.28e-9 Drug-induced liver injury (flucloxacillin); CRC cis rs6460942 0.908 rs7781919 chr7:12235351 T/C cg06484146 chr7:12443880 VWDE -0.58 -6.12 -0.32 2.61e-9 Coronary artery disease; CRC cis rs8031584 0.652 rs2691683 chr15:31135060 A/G cg14829155 chr15:31115871 NA 0.65 10.16 0.49 2.92e-21 Huntington's disease progression; CRC cis rs9911578 1.000 rs302848 chr17:56686454 C/T cg12560992 chr17:57184187 TRIM37 0.91 16.72 0.68 7.78e-46 Intelligence (multi-trait analysis); CRC cis rs6951245 0.935 rs11763765 chr7:1060510 C/T cg26224354 chr7:1096374 C7orf50;GPR146 -0.88 -11.0 -0.52 3.43e-24 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs597539 0.615 rs583182 chr11:68678634 C/T cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.86 15.31 0.64 2.6e-40 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs3764400 0.567 rs1452662 chr17:46293310 C/T cg10706073 chr17:46328419 SKAP1 -0.61 -6.65 -0.34 1.23e-10 Body mass index; CRC cis rs763121 0.626 rs5757236 chr22:39073824 T/C cg06022373 chr22:39101656 GTPBP1 0.8 12.62 0.57 4.84e-30 Menopause (age at onset); CRC cis rs7493 1.000 rs2286232 chr7:95039445 C/T cg21856205 chr7:94953877 PON1 -0.49 -6.44 -0.33 4.12e-10 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs4862750 0.872 rs1991254 chr4:187875375 T/G cg27532560 chr4:187881888 NA -0.55 -9.83 -0.48 3.65e-20 Lobe attachment (rater-scored or self-reported); CRC cis rs7647973 0.696 rs3087866 chr3:49054692 A/G cg20833759 chr3:49053208 WDR6;DALRD3 0.76 11.72 0.54 9.6e-27 Menarche (age at onset); CRC cis rs11711311 0.869 rs1026364 chr3:113370010 G/T cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.51 -6.86 -0.35 3.35e-11 IgG glycosylation; CRC cis rs4819052 1.000 rs2297285 chr21:46705621 A/G cg02159808 chr21:46707872 POFUT2;LOC642852 -0.65 -7.83 -0.4 6.72e-14 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs7614311 0.636 rs73117045 chr3:63910613 A/G cg22134162 chr3:63841271 THOC7 -0.58 -5.84 -0.31 1.27e-8 Lung function (FVC);Lung function (FEV1); CRC trans rs4332037 0.851 rs28728306 chr7:1961814 C/A cg11693508 chr17:37793320 STARD3 0.68 8.24 0.41 4.01e-15 Bipolar disorder; CRC cis rs10274279 1.000 rs73163815 chr7:157388047 A/G cg26886268 chr7:157387156 PTPRN2 -0.48 -5.83 -0.31 1.33e-8 Myopia (pathological); CRC cis rs7666738 0.830 rs13328042 chr4:99055406 A/G cg05340658 chr4:99064831 C4orf37 0.6 9.29 0.46 2.15e-18 Colonoscopy-negative controls vs population controls; CRC cis rs1555895 0.566 rs1057304 chr10:853106 T/C cg10556349 chr10:835070 NA -0.38 -7.49 -0.38 6.21e-13 Survival in rectal cancer; CRC trans rs948562 1.000 rs3829218 chr11:58331309 A/G cg26660744 chr1:1573181 CDK11B 0.53 6.19 0.32 1.83e-9 Lymphoma; CRC cis rs920590 0.527 rs79929516 chr8:19650050 G/C cg03894339 chr8:19674705 INTS10 0.57 7.38 0.38 1.28e-12 Acute lymphoblastic leukemia (childhood); CRC cis rs754466 0.580 rs10430530 chr10:79582812 T/C cg26805224 chr10:79626177 DLG5 -0.51 -7.49 -0.38 6.23e-13 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs7618915 0.501 rs2109634 chr3:52752075 T/G cg15147215 chr3:52552868 STAB1 -0.63 -10.57 -0.5 1.14e-22 Bipolar disorder; CRC cis rs6496667 1.000 rs1839972 chr15:90891354 A/G cg04176472 chr15:90893244 GABARAPL3 0.55 8.51 0.42 6.22e-16 Rheumatoid arthritis; CRC cis rs12024301 0.557 rs78535748 chr1:183620483 A/G cg11505048 chr1:183622726 RGL1;APOBEC4 0.81 7.14 0.37 5.93e-12 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs2408955 0.561 rs11168365 chr12:48421772 A/G cg21466736 chr12:48725269 NA 0.45 6.68 0.35 1.01e-10 Glycated hemoglobin levels; CRC trans rs11039798 0.588 rs61932767 chr11:48704806 C/T cg15704280 chr7:45808275 SEPT13 0.6 6.35 0.33 7.06e-10 Axial length; CRC cis rs9303280 0.840 rs12939457 chr17:38032188 T/C cg20243544 chr17:37824526 PNMT 0.37 5.69 0.3 2.82e-8 Self-reported allergy; CRC cis rs9443645 0.869 rs4706080 chr6:79760997 C/T cg09184832 chr6:79620586 NA -0.51 -9.37 -0.46 1.24e-18 Intelligence (multi-trait analysis); CRC cis rs8060686 0.565 rs8057577 chr16:68033143 C/T cg07125278 chr16:67683757 RLTPR -0.57 -5.83 -0.31 1.29e-8 HDL cholesterol;Metabolic syndrome; CRC cis rs10788264 0.621 rs9633733 chr10:124056546 A/G cg09507567 chr10:124027408 NA -0.33 -7.27 -0.37 2.66e-12 Total body bone mineral density; CRC cis rs9513627 0.573 rs4771336 chr13:100210610 T/G cg12790874 chr13:100310405 CLYBL 0.4 5.86 0.31 1.1e-8 Obesity-related traits; CRC cis rs4073416 0.508 rs12587057 chr14:66066375 C/T cg03016385 chr14:66212404 NA -0.46 -6.3 -0.33 9.66e-10 N-glycan levels; CRC cis rs947211 0.846 rs823155 chr1:205762946 T/C cg17178900 chr1:205818956 PM20D1 0.41 5.91 0.31 8.78e-9 Parkinson's disease; CRC cis rs3087591 0.919 rs7406870 chr17:29590617 G/A cg24425628 chr17:29625626 OMG;NF1 0.8 13.47 0.6 3.13e-33 Hip circumference; CRC cis rs7258465 0.896 rs8103660 chr19:18566395 T/C cg10790698 chr19:18539756 SSBP4 -0.45 -8.64 -0.43 2.47e-16 Breast cancer; CRC cis rs11098499 0.789 rs10212719 chr4:120254437 T/C cg24375607 chr4:120327624 NA 0.48 7.63 0.39 2.56e-13 Corneal astigmatism; CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg14797243 chr11:68671428 IGHMBP2;MRPL21 -0.55 -6.87 -0.35 3.23e-11 Diisocyanate-induced asthma; CRC cis rs6088580 0.634 rs1205345 chr20:32914699 A/G cg24642439 chr20:33292090 TP53INP2 -0.4 -6.71 -0.35 8.47e-11 Glomerular filtration rate (creatinine); CRC cis rs4665809 0.590 rs6730310 chr2:26419470 C/G cg25036284 chr2:26402008 FAM59B -0.61 -7.66 -0.39 2.09e-13 Gut microbiome composition (summer); CRC cis rs7259376 0.936 rs1975173 chr19:22534538 C/G cg02657401 chr19:22469223 NA -0.32 -7.27 -0.37 2.6e-12 Menopause (age at onset); CRC cis rs889398 0.802 rs2291959 chr16:69873992 T/G cg00738113 chr16:70207722 CLEC18C -0.37 -6.22 -0.32 1.48e-9 Body mass index; CRC cis rs10208940 0.841 rs12713645 chr2:68765627 G/A cg12452813 chr2:68675892 NA 0.47 5.83 0.31 1.35e-8 Urate levels in lean individuals; CRC cis rs1046896 0.520 rs9895409 chr17:80902719 C/T cg03160526 chr17:80928410 B3GNTL1 0.63 8.86 0.44 5.11e-17 Glycated hemoglobin levels; CRC cis rs11674184 0.714 rs9789525 chr2:11724580 G/T cg07314298 chr2:11723111 GREB1 -0.66 -12.06 -0.55 5.49e-28 Endometriosis; CRC cis rs2204008 0.571 rs8175738 chr12:38311234 C/T cg13010199 chr12:38710504 ALG10B -0.39 -5.63 -0.3 3.91e-8 Bladder cancer; CRC cis rs68170813 0.605 rs74632724 chr7:107136759 A/G cg02696742 chr7:106810147 HBP1 -0.59 -6.14 -0.32 2.36e-9 Coronary artery disease; CRC cis rs4474465 0.736 rs10899542 chr11:78246572 T/G cg27205649 chr11:78285834 NARS2 0.49 6.19 0.32 1.77e-9 Alzheimer's disease (survival time); CRC cis rs1008375 0.966 rs10939735 chr4:17578891 A/G cg16339924 chr4:17578868 LAP3 0.69 8.89 0.44 4.09e-17 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs2019137 0.560 rs10175462 chr2:113988492 G/A cg01577475 chr2:114033581 PAX8;LOC440839 -0.25 -6.36 -0.33 6.86e-10 Lymphocyte counts; CRC cis rs7666738 0.830 rs7663924 chr4:99037679 A/G cg05340658 chr4:99064831 C4orf37 -0.64 -10.25 -0.49 1.46e-21 Colonoscopy-negative controls vs population controls; CRC cis rs6963495 0.818 rs56165465 chr7:105180384 C/T cg19920283 chr7:105172520 RINT1 0.51 6.04 0.32 4.16e-9 Bipolar disorder (body mass index interaction); CRC cis rs7584330 0.518 rs74003105 chr2:238446851 T/C cg14458575 chr2:238380390 NA 0.7 8.62 0.43 2.8e-16 Prostate cancer; CRC cis rs10992471 0.528 rs2296666 chr9:95274261 C/T cg14631576 chr9:95140430 CENPP 0.33 6.18 0.32 1.88e-9 Visceral adipose tissue/subcutaneous adipose tissue ratio; CRC cis rs6460942 0.591 rs6942551 chr7:12338356 C/T cg20607287 chr7:12443886 VWDE -0.55 -6.19 -0.32 1.78e-9 Coronary artery disease; CRC cis rs9488822 0.676 rs6918059 chr6:116349041 C/T cg15226275 chr6:116381976 FRK 0.3 8.59 0.43 3.64e-16 Cholesterol, total;LDL cholesterol; CRC cis rs3087591 0.960 rs12949230 chr17:29461899 G/A cg24425628 chr17:29625626 OMG;NF1 0.88 16.66 0.68 1.28e-45 Hip circumference; CRC trans rs2228479 0.850 rs45567439 chr16:89814604 G/A cg24644049 chr4:85504048 CDS1 0.9 7.46 0.38 7.69e-13 Skin colour saturation; CRC cis rs2882667 0.931 rs10075893 chr5:138355871 A/G cg09476006 chr5:138032270 NA -0.43 -7.02 -0.36 1.27e-11 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs9560113 0.573 rs61955236 chr13:112242861 G/A cg10483660 chr13:112241077 NA 0.65 12.57 0.57 7.18e-30 Menarche (age at onset); CRC cis rs12575642 0.660 rs58632573 chr11:63896299 C/T cg18225595 chr11:63971243 STIP1 0.56 7.28 0.37 2.51e-12 Attention deficit hyperactivity disorder; CRC cis rs11758351 0.789 rs4496782 chr6:26184617 T/C cg01420254 chr6:26195488 NA 0.49 6.18 0.32 1.89e-9 Gout;Renal underexcretion gout; CRC cis rs611744 0.647 rs585077 chr8:109245497 C/T cg21045802 chr8:109455806 TTC35 0.42 6.68 0.35 1.05e-10 Dupuytren's disease; CRC trans rs7267979 0.808 rs84816 chr20:25459919 G/A cg17903999 chr18:56338584 MALT1 -0.42 -7.0 -0.36 1.44e-11 Liver enzyme levels (alkaline phosphatase); CRC cis rs4319547 0.656 rs7975747 chr12:122816995 C/T cg23029597 chr12:123009494 RSRC2 -0.51 -6.19 -0.32 1.76e-9 Body mass index; CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg00742472 chr14:31889912 NA 0.42 6.69 0.35 9.79e-11 Obesity-related traits; CRC trans rs12478296 0.681 rs55802421 chr2:243033962 C/T cg18288967 chr1:45987694 PRDX1 0.68 7.52 0.38 5.32e-13 Obesity-related traits; CRC trans rs12599106 0.709 rs1501462 chr16:34964515 A/T cg26668828 chr6:292823 DUSP22 -0.68 -10.11 -0.49 4.32e-21 Menopause (age at onset); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg01457183 chr3:180707371 DNAJC19 0.37 6.14 0.32 2.34e-9 Liver disease severity in Alagille syndrome; CRC cis rs6502050 0.805 rs8082653 chr17:80162382 G/A cg19223190 chr17:80058835 NA 0.43 6.85 0.35 3.59e-11 Life satisfaction; CRC cis rs240764 0.578 rs1414734 chr6:101201823 T/C cg09795085 chr6:101329169 ASCC3 0.41 5.68 0.3 3.04e-8 Neuroticism; CRC cis rs7923609 1.000 rs10822163 chr10:65124098 C/G cg08743896 chr10:65200160 JMJD1C -0.4 -5.74 -0.3 2.14e-8 Educational attainment;Liver enzyme levels (alkaline phosphatase); CRC cis rs1950626 0.750 rs35820579 chr14:101435515 T/C cg02351406 chr14:101447389 SNORD114-20;SNORD114-21 0.95 15.47 0.65 6.15e-41 Pelvic organ prolapse (moderate/severe); CRC cis rs7945705 0.967 rs56316046 chr11:8876598 G/T cg00186954 chr11:8933980 ST5;C11orf17 0.46 7.08 0.36 8.81e-12 Hemoglobin concentration; CRC cis rs7618915 0.501 rs13085775 chr3:52678370 C/T cg18099408 chr3:52552593 STAB1 -0.47 -7.97 -0.4 2.57e-14 Bipolar disorder; CRC cis rs11098499 0.754 rs1980026 chr4:120251643 C/A cg09307838 chr4:120376055 NA 0.61 9.59 0.47 2.22e-19 Corneal astigmatism; CRC cis rs2836974 0.932 rs56306759 chr21:40608106 G/A cg11644478 chr21:40555479 PSMG1 0.79 12.03 0.55 7.39e-28 Cognitive function; CRC cis rs1552244 0.816 rs9847657 chr3:10173492 G/T cg18598329 chr3:10140678 FANCD2;C3orf24 -0.69 -9.67 -0.47 1.23e-19 Alzheimer's disease; CRC cis rs7726839 0.540 rs72703078 chr5:594987 A/C cg14541582 chr5:601475 NA -0.36 -7.37 -0.38 1.42e-12 Obesity-related traits; CRC cis rs7120118 0.517 rs17726390 chr11:47319706 C/T cg25783544 chr11:47291846 MADD 0.61 5.68 0.3 2.96e-8 HDL cholesterol; CRC cis rs3741151 0.687 rs7933355 chr11:73236817 G/C cg17517138 chr11:73019481 ARHGEF17 0.84 7.62 0.39 2.78e-13 GIP levels in response to oral glucose tolerance test (120 minutes); CRC cis rs926938 0.527 rs360681 chr1:115496741 C/G cg12756093 chr1:115239321 AMPD1 0.48 7.02 0.36 1.29e-11 Autism; CRC trans rs61931739 0.534 rs10844819 chr12:34261389 G/T cg26384229 chr12:38710491 ALG10B 0.51 6.5 0.34 2.97e-10 Morning vs. evening chronotype; CRC cis rs780096 0.587 rs10205219 chr2:27568565 T/C cg21248554 chr2:27665150 KRTCAP3 -0.28 -6.51 -0.34 2.81e-10 Total body bone mineral density; CRC cis rs394563 0.967 rs369643 chr6:149799798 A/G cg03678062 chr6:149772716 ZC3H12D -0.35 -6.19 -0.32 1.79e-9 Dupuytren's disease; CRC cis rs2836950 0.561 rs34705151 chr21:40553344 G/A cg17971929 chr21:40555470 PSMG1 -0.58 -8.53 -0.43 5.26e-16 Menarche (age at onset); CRC cis rs1801251 1.000 rs1867778 chr2:233679644 C/T cg25237894 chr2:233734115 C2orf82 -0.51 -8.31 -0.42 2.54e-15 Coronary artery disease; CRC cis rs7552404 0.731 rs12090849 chr1:76400261 A/G cg22875332 chr1:76189707 ACADM 0.47 5.91 0.31 8.51e-9 Blood metabolite levels;Acylcarnitine levels; CRC cis rs7945718 0.967 rs11826129 chr11:12768883 G/A cg25843174 chr11:12811716 TEAD1 0.49 9.3 0.46 1.99e-18 Educational attainment (years of education); CRC cis rs939584 1.000 rs7570993 chr2:652565 A/G cg03610516 chr2:642275 NA -0.43 -5.93 -0.31 7.78e-9 Body mass index; CRC cis rs9368481 0.761 rs9379952 chr6:26987900 A/T cg18278486 chr6:26987575 LOC100270746;C6orf41 -0.52 -8.32 -0.42 2.4e-15 Autism spectrum disorder or schizophrenia; CRC cis rs3824867 0.879 rs4752837 chr11:47465955 G/A cg05585544 chr11:47624801 NA -0.41 -6.38 -0.33 6.15e-10 Mean corpuscular hemoglobin; CRC cis rs4555082 0.874 rs113291192 chr14:105738181 C/T cg06808227 chr14:105710500 BRF1 -0.6 -8.64 -0.43 2.55e-16 Mean platelet volume;Platelet distribution width; CRC cis rs2976388 0.609 rs2585148 chr8:143796193 C/G cg20041105 chr8:143859282 LYNX1 0.44 7.94 0.4 3.33e-14 Urinary tract infection frequency; CRC cis rs1865760 0.622 rs10946807 chr6:26079638 T/C cg17691542 chr6:26056736 HIST1H1C 0.63 8.88 0.44 4.28e-17 Height; CRC cis rs877282 0.842 rs35117541 chr10:764683 C/T cg17470449 chr10:769945 NA 0.66 8.48 0.42 7.57e-16 Uric acid levels; CRC cis rs7692995 1.000 rs7660642 chr4:17956017 T/C cg08925142 chr4:18023851 LCORL -0.51 -5.6 -0.3 4.5e-8 Height; CRC trans rs875971 0.571 rs78668714 chr7:65939451 G/A cg02869306 chr7:64672164 INTS4L1 -0.42 -6.03 -0.32 4.31e-9 Aortic root size; CRC cis rs12497850 0.865 rs13072911 chr3:48962128 T/G cg07636037 chr3:49044803 WDR6 1.02 18.27 0.71 5.71e-52 Parkinson's disease; CRC trans rs1814175 0.588 rs10466497 chr11:49864381 A/T cg11707556 chr5:10655725 ANKRD33B -0.53 -10.22 -0.49 1.81e-21 Height; CRC cis rs72781680 0.898 rs56303870 chr2:24086944 G/A cg08917208 chr2:24149416 ATAD2B 0.92 9.37 0.46 1.23e-18 Lymphocyte counts; CRC cis rs1816752 0.837 rs9318530 chr13:24998557 A/G cg02811702 chr13:24901961 NA -0.45 -6.12 -0.32 2.59e-9 Obesity-related traits; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg26270738 chr6:83777272 DOPEY1 0.46 6.86 0.35 3.42e-11 Response to antipsychotic treatment; CRC cis rs9488822 0.676 rs1999929 chr6:116381994 T/C cg15226275 chr6:116381976 FRK 0.31 8.66 0.43 2.11e-16 Cholesterol, total;LDL cholesterol; CRC cis rs10751667 0.643 rs11246348 chr11:939476 G/C cg23136738 chr11:925521 AP2A2 -0.41 -6.73 -0.35 7.76e-11 Alzheimer's disease (late onset); CRC cis rs853679 0.527 rs853693 chr6:28282648 C/T cg15845792 chr6:28175446 NA 0.42 5.74 0.3 2.15e-8 Depression; CRC cis rs8060686 0.641 rs9674047 chr16:68045046 G/A cg26727032 chr16:67993705 SLC12A4 -0.61 -8.02 -0.4 1.86e-14 HDL cholesterol;Metabolic syndrome; CRC cis rs7089973 0.604 rs7903663 chr10:116609904 G/A cg23260525 chr10:116636907 FAM160B1 0.35 8.11 0.41 1.04e-14 Bipolar disorder or attention deficit hyperactivity disorder; CRC cis rs60843830 1.000 rs3828165 chr2:220889 G/A cg25945732 chr2:264204 ACP1;SH3YL1 0.74 11.68 0.54 1.34e-26 Spherical equivalent (joint analysis main effects and education interaction); CRC cis rs3796352 1.000 rs34943350 chr3:53012888 C/T cg07884673 chr3:53033167 SFMBT1 0.75 5.95 0.31 6.75e-9 Immune reponse to smallpox (secreted IL-2); CRC cis rs736408 0.812 rs2071508 chr3:52826846 A/G cg15147215 chr3:52552868 STAB1 0.51 7.48 0.38 6.68e-13 Bipolar disorder; CRC cis rs10991814 0.844 rs7860510 chr9:94128796 C/G cg14446406 chr9:93919335 NA 0.58 6.36 0.33 6.84e-10 Neutrophil percentage of granulocytes; CRC cis rs4713118 0.527 rs4713151 chr6:28136356 G/A cg06470822 chr6:28175283 NA 1.03 13.59 0.6 1.04e-33 Parkinson's disease; CRC cis rs1008375 0.966 rs2315645 chr4:17579678 G/C cg16339924 chr4:17578868 LAP3 0.6 7.91 0.4 3.86e-14 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs9640161 0.750 rs4395803 chr7:150025367 A/C cg13722127 chr7:150037890 RARRES2 0.5 7.94 0.4 3.32e-14 Blood protein levels;Circulating chemerin levels; CRC cis rs2985684 0.948 rs2883437 chr14:50031666 A/G cg10008539 chr14:50087325 RPL36AL;MGAT2 -0.42 -5.65 -0.3 3.52e-8 Carotid intima media thickness; CRC cis rs2228479 0.850 rs11639906 chr16:89798183 T/C cg19635926 chr16:89946313 TCF25 0.68 6.13 0.32 2.57e-9 Skin colour saturation; CRC cis rs7224737 0.956 rs8081327 chr17:40274200 G/A cg00647820 chr17:40259828 DHX58 -0.46 -6.49 -0.34 3.15e-10 Fibrinogen levels; CRC cis rs926938 0.618 rs360617 chr1:115404099 G/A cg01522456 chr1:115632236 TSPAN2 -0.37 -5.76 -0.3 1.9e-8 Autism; CRC cis rs875971 0.660 rs801190 chr7:66033033 C/T cg18876405 chr7:65276391 NA -0.6 -10.83 -0.51 1.4e-23 Aortic root size; CRC cis rs6502050 0.835 rs66932937 chr17:80116803 G/A cg02741985 chr17:80059408 CCDC57 0.43 7.18 0.37 4.56e-12 Life satisfaction; CRC cis rs9787249 0.915 rs6664570 chr1:40206298 G/A cg01941586 chr1:40203715 PPIE -0.45 -6.33 -0.33 7.9e-10 Blood protein levels; CRC cis rs629535 0.773 rs681534 chr8:70056964 A/C cg26132723 chr8:70041827 NA 0.35 5.86 0.31 1.15e-8 Dupuytren's disease; CRC cis rs6951245 1.000 rs1881123 chr7:1084706 C/T cg20603222 chr7:1096387 C7orf50;GPR146 -0.69 -8.02 -0.4 1.87e-14 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs9322193 0.923 rs11155677 chr6:150078089 C/G cg07701084 chr6:150067640 NUP43 0.59 8.71 0.43 1.48e-16 Lung cancer; CRC cis rs10982256 1.000 rs4979414 chr9:117260185 C/T cg13636371 chr9:117264095 DFNB31 0.35 6.78 0.35 5.52e-11 Bipolar disorder; CRC cis rs72945132 0.882 rs7116059 chr11:70159690 G/T cg00319359 chr11:70116639 PPFIA1 0.68 7.51 0.38 5.61e-13 Coronary artery disease; CRC cis rs6502050 0.835 rs4789744 chr17:80101506 A/C cg19223190 chr17:80058835 NA 0.4 6.36 0.33 6.88e-10 Life satisfaction; CRC cis rs4141404 0.701 rs5753483 chr22:31549581 A/G cg22777020 chr22:31556080 RNF185 -0.48 -5.77 -0.3 1.85e-8 Paclitaxel-induced neuropathy; CRC cis rs2996428 0.667 rs7511793 chr1:3744249 A/G cg13057898 chr1:3703894 LRRC47 0.55 7.24 0.37 3.22e-12 Red cell distribution width; CRC cis rs1499614 1.000 rs2707838 chr7:66159201 C/T cg12463550 chr7:65579703 CRCP 0.64 5.79 0.3 1.66e-8 Gout; CRC cis rs28386778 0.769 rs6504179 chr17:61812995 T/G cg06873352 chr17:61820015 STRADA 0.71 12.42 0.56 2.64e-29 Prudent dietary pattern; CRC trans rs4332037 0.522 rs4721098 chr7:1881527 G/C cg11693508 chr17:37793320 STARD3 -0.64 -8.34 -0.42 2.01e-15 Bipolar disorder; CRC cis rs6951245 1.000 rs79765398 chr7:1073764 A/G cg18402987 chr7:1209562 NA 0.64 6.79 0.35 5.19e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs7945705 0.902 rs10769979 chr11:9010659 C/T cg21881798 chr11:8931708 C11orf17;ST5 0.63 9.82 0.48 4.07e-20 Hemoglobin concentration; CRC cis rs6681460 0.932 rs523188 chr1:67174422 A/G cg02459107 chr1:67143332 SGIP1 0.37 6.51 0.34 2.8e-10 Presence of antiphospholipid antibodies; CRC cis rs8114671 0.562 rs6088653 chr20:33520321 T/C cg07148914 chr20:33460835 GGT7 0.4 6.56 0.34 2.04e-10 Height; CRC cis rs4481887 0.927 rs4603165 chr1:248473799 T/A cg13385794 chr1:248469461 NA 0.38 6.65 0.34 1.26e-10 Common traits (Other); CRC trans rs2243480 0.803 rs35480979 chr7:65357084 A/G cg10756647 chr7:56101905 PSPH 0.73 7.72 0.39 1.46e-13 Diabetic kidney disease; CRC cis rs4665809 1.000 rs12471809 chr2:26307140 A/G cg25036284 chr2:26402008 FAM59B -0.45 -5.81 -0.31 1.45e-8 Gut microbiome composition (summer); CRC cis rs1865760 0.566 rs2032443 chr6:26046802 A/G cg17691542 chr6:26056736 HIST1H1C 0.55 8.34 0.42 2.01e-15 Height; CRC cis rs875971 0.522 rs9530 chr7:65425894 A/G cg00343986 chr7:65444356 GUSB 0.59 8.83 0.44 6.37e-17 Aortic root size; CRC cis rs6860806 0.661 rs1588263 chr5:131577158 T/C cg11843238 chr5:131593191 PDLIM4 0.43 8.11 0.41 9.95e-15 Breast cancer; CRC cis rs6088590 1.000 rs910870 chr20:33292893 T/C cg24642439 chr20:33292090 TP53INP2 0.56 9.93 0.48 1.67e-20 Coronary artery disease; CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg23819836 chr6:15663134 DTNBP1 0.38 6.02 0.31 4.59e-9 Obesity-related traits; CRC cis rs16924133 0.793 rs58478170 chr11:33136631 C/T cg05567920 chr11:33183001 CSTF3 -0.78 -5.92 -0.31 7.95e-9 Anger; CRC cis rs56161922 0.818 rs4437879 chr1:207875977 G/A cg11752769 chr1:207818423 CR1L -0.55 -5.7 -0.3 2.65e-8 Response to paliperidone in schizophrenia (PANSS score);Response to paliperidone in schizophrenia (positive Marder score); CRC cis rs10504229 0.683 rs7838958 chr8:58136968 T/C cg22535103 chr8:58192502 C8orf71 -0.7 -9.34 -0.46 1.47e-18 Developmental language disorder (linguistic errors); CRC cis rs9487051 1.000 rs9386795 chr6:109616528 G/A cg01475377 chr6:109611718 NA -0.45 -7.98 -0.4 2.39e-14 Reticulocyte fraction of red cells; CRC cis rs3540 0.960 rs12440447 chr15:91022694 C/G cg04176472 chr15:90893244 GABARAPL3 0.35 6.07 0.32 3.51e-9 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; CRC cis rs4664308 0.618 rs17830755 chr2:160888835 T/C cg03641300 chr2:160917029 PLA2R1 -0.56 -8.56 -0.43 4.29e-16 Idiopathic membranous nephropathy; CRC cis rs3011225 0.710 rs3011224 chr1:44318483 C/T cg12908607 chr1:44402522 ARTN -0.53 -9.51 -0.46 4.11e-19 Amyotrophic lateral sclerosis (age of onset); CRC cis rs7618501 0.633 rs2624843 chr3:49997963 G/A cg24308560 chr3:49941425 MST1R -0.54 -8.99 -0.44 1.93e-17 Intelligence (multi-trait analysis); CRC cis rs798554 1.000 rs798545 chr7:2762386 C/T cg04166393 chr7:2884313 GNA12 0.48 6.67 0.34 1.11e-10 Height; CRC cis rs2842992 0.915 rs1967802 chr6:160097791 G/A cg19482086 chr6:160211437 TCP1;MRPL18 0.7 8.58 0.43 3.85e-16 Age-related macular degeneration (geographic atrophy); CRC cis rs7953249 0.618 rs2650000 chr12:121388962 G/T cg02403541 chr12:121454288 C12orf43 0.43 6.29 0.33 9.91e-10 Invasive epithelial ovarian cancer;High-grade serous ovarian cancer;Chronic obstructive pulmonary disease-related biomarkers;N-glycan levels;Serous invasive ovarian cancer;Epithelial ovarian cancer; CRC trans rs7248779 0.512 rs12610522 chr19:2413228 C/T cg25835954 chr13:50160062 RCBTB1 0.52 7.82 0.4 7.04e-14 Cortisol levels (saliva); CRC cis rs2535633 0.631 rs2581819 chr3:53016552 C/A cg11645453 chr3:52864694 ITIH4 -0.42 -7.81 -0.4 7.66e-14 Body mass index; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg06233122 chr8:74888597 TMEM70 0.45 6.21 0.32 1.59e-9 Anxiety disorder; CRC cis rs7085104 0.513 rs192569 chr10:104577915 T/C cg04362960 chr10:104952993 NT5C2 -0.55 -7.83 -0.4 6.67e-14 Immature fraction of reticulocytes;Schizophrenia; CRC cis rs4789693 1.000 rs4789693 chr17:80421870 A/C cg04308225 chr17:80449738 NA 0.46 6.52 0.34 2.59e-10 Glucocorticoid-induced osteonecrosis; CRC cis rs853679 0.517 rs9368555 chr6:28108967 T/C cg02631126 chr6:28058918 ZSCAN12L1 0.29 5.91 0.31 8.38e-9 Depression; CRC cis rs4713118 0.539 rs510987 chr6:27847517 G/A cg20933634 chr6:27740509 NA 0.5 6.94 0.36 2.07e-11 Parkinson's disease; CRC cis rs4268898 0.636 rs9636438 chr2:24460566 C/T cg06627628 chr2:24431161 ITSN2 0.85 11.63 0.54 1.96e-26 Asthma; CRC cis rs7119 0.717 rs12904584 chr15:77815991 C/T cg10437265 chr15:77819839 NA 0.69 12.74 0.57 1.76e-30 Type 2 diabetes; CRC cis rs8180040 0.966 rs7649234 chr3:47494380 G/C cg27129171 chr3:47204927 SETD2 0.6 9.62 0.47 1.83e-19 Colorectal cancer; CRC trans rs3780486 0.718 rs7859454 chr9:33119583 T/A cg20290983 chr6:43655470 MRPS18A 0.97 12.08 0.55 4.7e-28 IgG glycosylation; CRC cis rs3849570 0.643 rs10779987 chr3:81970856 C/T cg07356753 chr3:81810745 GBE1 -0.47 -6.42 -0.33 4.89e-10 Waist circumference;Body mass index; CRC cis rs6076065 0.723 rs2424554 chr20:23415867 T/C cg11657817 chr20:23433608 CST11 0.45 6.47 0.34 3.47e-10 Facial morphology (factor 15, philtrum width); CRC cis rs2842992 0.789 rs2842969 chr6:160145364 C/T cg11366901 chr6:160182831 ACAT2 0.93 12.83 0.58 7.94e-31 Age-related macular degeneration (geographic atrophy); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg18029778 chr7:104654746 MLL5;LOC100216545 0.38 6.35 0.33 7.1e-10 Liver disease severity in Alagille syndrome; CRC cis rs9487051 0.872 rs9386789 chr6:109603218 A/G cg01475377 chr6:109611718 NA -0.47 -8.75 -0.43 1.15e-16 Reticulocyte fraction of red cells; CRC cis rs2342371 0.599 rs7618690 chr3:196146039 T/C cg15048948 chr3:196158458 UBXN7 0.5 6.16 0.32 2.17e-9 Fat distribution (HIV); CRC cis rs34375054 0.526 rs4412800 chr12:125674742 C/T cg05341575 chr12:125625032 AACS 0.39 5.95 0.31 6.84e-9 Post bronchodilator FEV1/FVC ratio; CRC cis rs2249694 0.586 rs9418987 chr10:135324409 A/G cg16964102 chr10:135390573 NA -0.44 -6.82 -0.35 4.39e-11 Obesity-related traits; CRC cis rs2836974 0.568 rs11910906 chr21:40685662 T/C cg11644478 chr21:40555479 PSMG1 -0.65 -10.05 -0.48 6.82e-21 Cognitive function; CRC cis rs35995292 0.534 rs7793692 chr7:38940580 G/C cg19327137 chr7:38886074 VPS41 0.65 10.94 0.52 5.64e-24 Subjective well-being (multi-trait analysis); CRC cis rs77633900 0.614 rs203753 chr15:76946195 A/T cg21673338 chr15:77095150 SCAPER -0.73 -7.26 -0.37 2.89e-12 Non-glioblastoma glioma;Glioma; CRC cis rs853679 0.585 rs201001 chr6:27808899 T/C cg03623178 chr6:28175578 NA 0.58 6.39 0.33 5.64e-10 Depression; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg09311052 chr1:154531418 UBE2Q1 0.53 6.89 0.36 2.85e-11 Thyroid stimulating hormone; CRC cis rs6921919 0.525 rs1361386 chr6:28305604 G/A cg21251018 chr6:28226885 NKAPL 0.49 7.8 0.4 8.17e-14 Autism spectrum disorder or schizophrenia; CRC cis rs1448094 0.533 rs2169572 chr12:86170370 G/T cg25456477 chr12:86230367 RASSF9 -0.33 -5.77 -0.3 1.83e-8 Major depressive disorder; CRC cis rs6504622 0.599 rs197913 chr17:44990046 G/C cg16759221 chr17:45003025 GOSR2 -0.61 -9.72 -0.47 8.31e-20 Orofacial clefts; CRC cis rs270601 0.739 rs3900945 chr5:131592870 T/C cg18758796 chr5:131593413 PDLIM4 0.49 8.98 0.44 2.2e-17 Acylcarnitine levels; CRC cis rs898097 0.841 rs12453162 chr17:80859971 C/T cg03160526 chr17:80928410 B3GNTL1 -0.41 -5.87 -0.31 1.07e-8 Breast cancer; CRC cis rs7524258 0.868 rs4243825 chr1:7308264 T/C cg07173049 chr1:7289937 CAMTA1 0.6 9.4 0.46 9.56e-19 Tourette's syndrome or obsessive-compulsive disorder; CRC trans rs3733585 0.673 rs4627861 chr4:9954238 T/G cg26043149 chr18:55253948 FECH -0.5 -7.71 -0.39 1.51e-13 Cleft plate (environmental tobacco smoke interaction); CRC trans rs9291683 0.552 rs11736410 chr4:10017241 G/A cg26043149 chr18:55253948 FECH 0.51 7.98 0.4 2.39e-14 Bone mineral density; CRC cis rs7772486 0.558 rs62435775 chr6:146136415 G/C cg13319975 chr6:146136371 FBXO30 -0.62 -8.99 -0.44 2.04e-17 Lobe attachment (rater-scored or self-reported); CRC cis rs4711350 0.765 rs2182658 chr6:33748831 G/T cg07979401 chr6:33739406 LEMD2 0.46 5.96 0.31 6.32e-9 Schizophrenia; CRC trans rs2797160 0.935 rs6940748 chr6:125994080 C/T cg05039488 chr6:79577232 IRAK1BP1 -0.5 -7.51 -0.38 5.79e-13 Endometrial cancer; CRC cis rs2153535 0.541 rs1414347 chr6:8471831 T/C cg07606381 chr6:8435919 SLC35B3 0.69 11.0 0.52 3.47e-24 Motion sickness; CRC cis rs728616 0.867 rs77376252 chr10:81809382 C/T cg11900509 chr10:81946545 ANXA11 -0.56 -6.14 -0.32 2.4e-9 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs6499255 0.951 rs8046314 chr16:69697922 T/A cg04110750 chr16:69646130 NFAT5 -0.55 -7.63 -0.39 2.53e-13 IgE levels; CRC cis rs478304 0.651 rs12225620 chr11:65505448 T/C cg27068330 chr11:65405492 SIPA1 -0.67 -10.29 -0.49 9.9700000000000009e-22 Acne (severe); CRC cis rs10504229 0.683 rs16921937 chr8:58145010 A/G cg22535103 chr8:58192502 C8orf71 -0.71 -9.33 -0.46 1.64e-18 Developmental language disorder (linguistic errors); CRC cis rs4665809 0.652 rs2241739 chr2:26411894 C/T cg27170947 chr2:26402098 FAM59B -0.6 -8.07 -0.41 1.36e-14 Gut microbiome composition (summer); CRC cis rs2197308 0.740 rs1842595 chr12:37906223 G/A cg26384229 chr12:38710491 ALG10B -0.62 -9.31 -0.46 1.88e-18 Morning vs. evening chronotype; CRC cis rs3091242 0.967 rs3093614 chr1:25677844 T/A cg27572855 chr1:25598939 RHD -0.36 -6.35 -0.33 7.06e-10 Erythrocyte sedimentation rate; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg07092057 chr12:57914300 DDIT3 0.44 5.96 0.31 6.45e-9 Response to antipsychotic treatment; CRC cis rs7945705 0.967 rs34842234 chr11:8891894 G/A cg21881798 chr11:8931708 C11orf17;ST5 0.67 10.38 0.5 5.13e-22 Hemoglobin concentration; CRC cis rs2985684 0.894 rs2354439 chr14:50019417 G/C cg04989706 chr14:50066350 PPIL5 -0.56 -8.01 -0.4 1.96e-14 Carotid intima media thickness; CRC cis rs2579500 0.807 rs7584930 chr2:97298290 C/T cg23100626 chr2:96804247 ASTL -0.23 -5.65 -0.3 3.54e-8 Eosinophil counts;Eosinophil percentage of white cells; CRC cis rs9467711 0.606 rs9379851 chr6:26354780 A/C cg16898833 chr6:26189333 HIST1H4D 0.72 6.29 0.33 9.97e-10 Autism spectrum disorder or schizophrenia; CRC cis rs4689592 0.513 rs3857178 chr4:7066516 G/A cg19539972 chr4:7069911 GRPEL1 0.75 9.66 0.47 1.37e-19 Monocyte percentage of white cells; CRC cis rs9906695 0.950 rs56389898 chr17:32575213 A/T cg12698626 chr17:32581466 CCL2 0.46 5.95 0.31 6.96e-9 Monocyte percentage of white cells; CRC cis rs12188164 0.582 rs80273890 chr5:483057 C/T cg16322479 chr5:444228 EXOC3;C5orf55 0.54 7.44 0.38 9.06e-13 Cystic fibrosis severity; CRC cis rs9467603 0.858 rs972087 chr6:25872579 A/G cg08501292 chr6:25962987 TRIM38 0.79 7.9 0.4 4.18e-14 Intelligence (multi-trait analysis); CRC cis rs853679 0.517 rs9393896 chr6:28127703 C/T cg12963246 chr6:28129442 ZNF389 0.49 5.7 0.3 2.71e-8 Depression; CRC cis rs12144094 0.832 rs6683122 chr1:120242179 G/T cg20995928 chr1:120229863 NA 0.43 6.04 0.32 4.21e-9 Height; CRC cis rs7727544 0.735 rs272894 chr5:131662460 C/T cg24060327 chr5:131705240 SLC22A5 -0.36 -6.01 -0.31 5.05e-9 Blood metabolite levels; CRC cis rs898097 0.691 rs7222773 chr17:80907283 A/G cg19046167 chr17:80928561 B3GNTL1 0.47 8.1 0.41 1.11e-14 Breast cancer; CRC cis rs6951245 1.000 rs28528096 chr7:1070912 G/C cg03188948 chr7:1209495 NA 0.63 6.52 0.34 2.64e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs3823572 0.510 rs4731991 chr7:133689090 A/G cg03336402 chr7:133662267 EXOC4 -0.66 -9.61 -0.47 1.97e-19 Intelligence (multi-trait analysis); CRC cis rs1552244 1.000 rs67134728 chr3:10151431 G/C cg08888203 chr3:10149979 C3orf24 0.7 9.48 0.46 5.31e-19 Alzheimer's disease; CRC cis rs4689592 0.503 rs66885632 chr4:7053738 T/C cg19539972 chr4:7069911 GRPEL1 -0.8 -8.85 -0.44 5.62e-17 Monocyte percentage of white cells; CRC cis rs6502050 0.835 rs10163483 chr17:80110396 C/A cg11859384 chr17:80120422 CCDC57 -0.37 -5.85 -0.31 1.16e-8 Life satisfaction; CRC cis rs28374715 0.662 rs72737793 chr15:41516823 C/T cg18705301 chr15:41695430 NDUFAF1 -0.88 -13.33 -0.59 1.08e-32 Ulcerative colitis; CRC cis rs8177253 0.665 rs6774822 chr3:133442012 G/T cg01448562 chr3:133502909 NA -0.38 -6.12 -0.32 2.62e-9 Iron status biomarkers; CRC cis rs9303280 0.936 rs12950209 chr17:38049102 T/C cg11212589 chr17:38028394 ZPBP2 0.48 8.9 0.44 3.88e-17 Self-reported allergy; CRC cis rs995000 0.868 rs4409689 chr1:63177365 A/G cg19896129 chr1:63156450 NA 0.43 6.66 0.34 1.13e-10 Triglyceride levels; CRC cis rs4665809 0.590 rs10495756 chr2:26485586 A/G cg08067268 chr2:26466485 HADHB;HADHA 0.66 8.38 0.42 1.54e-15 Gut microbiome composition (summer); CRC cis rs3785574 0.962 rs2584614 chr17:61929445 C/T cg25654072 chr17:61904446 PSMC5;FTSJ3 0.43 5.93 0.31 7.73e-9 Height; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg08956724 chr16:29624832 SLC7A5P1 0.47 6.31 0.33 9.16e-10 Anxiety disorder; CRC cis rs912057 0.671 rs1024246 chr6:6743505 A/T cg06612196 chr6:6737390 NA 0.54 8.65 0.43 2.35e-16 Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction); CRC cis rs10504229 0.609 rs56289889 chr8:58116276 G/C cg02290350 chr8:58132656 NA -0.58 -8.16 -0.41 7.29e-15 Developmental language disorder (linguistic errors); CRC cis rs79839061 0.610 rs2279182 chr4:882625 T/G cg14530993 chr4:882597 GAK 0.78 7.96 0.4 2.74e-14 Intelligence (multi-trait analysis); CRC trans rs970548 0.697 rs11239534 chr10:45968590 A/T cg14222797 chr10:16859974 RSU1 0.64 6.37 0.33 6.35e-10 Total cholesterol levels;Cholesterol, total;HDL cholesterol;HDL cholesterol levels; CRC trans rs7395662 0.853 rs10838885 chr11:48398806 A/G cg21153622 chr11:89784906 NA -0.46 -7.23 -0.37 3.45e-12 HDL cholesterol; CRC cis rs1005277 0.505 rs200936 chr10:38134935 T/C cg25427524 chr10:38739819 LOC399744 -0.73 -12.86 -0.58 6.04e-31 Extrinsic epigenetic age acceleration; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg17164781 chr15:85144209 ZSCAN2 0.42 6.43 0.33 4.46e-10 Intelligence (multi-trait analysis); CRC cis rs881375 0.967 rs7034492 chr9:123687211 G/A cg14255062 chr9:123606675 PSMD5;LOC253039 0.41 5.95 0.31 6.99e-9 Rheumatoid arthritis; CRC cis rs1129187 0.755 rs9462855 chr6:42925936 G/C cg27588902 chr6:42928151 GNMT -0.4 -7.31 -0.37 2.02e-12 Alzheimer's disease in APOE e4+ carriers; CRC cis rs909002 0.849 rs10914458 chr1:32096746 T/C cg13919466 chr1:32135498 COL16A1 -0.31 -5.94 -0.31 7.21e-9 Intelligence (multi-trait analysis); CRC cis rs798554 0.683 rs1636264 chr7:2864586 G/T cg14895029 chr7:2775587 GNA12 -0.4 -6.14 -0.32 2.43e-9 Height; CRC cis rs2645694 0.532 rs2645706 chr4:77829606 A/C cg10057126 chr4:77819792 ANKRD56 0.34 5.81 0.3 1.51e-8 Emphysema distribution in smoking; CRC cis rs8044868 0.512 rs4788461 chr16:72156000 C/A cg23815491 chr16:72088622 HP 0.46 6.78 0.35 5.58e-11 Body mass index (change over time) in cancer or chronic obstructive pulmonary disease;Body mass index (change over time) in cancer; CRC cis rs4481887 0.504 rs6587439 chr1:248376070 A/G cg00666640 chr1:248458726 OR2T12 -0.41 -6.51 -0.34 2.81e-10 Common traits (Other); CRC cis rs9393692 0.645 rs11756673 chr6:26323505 A/G cg13736514 chr6:26305472 NA -0.66 -11.6 -0.54 2.63e-26 Educational attainment; CRC trans rs877282 0.786 rs10904558 chr10:797509 C/T cg22713356 chr15:30763199 NA 1.32 16.62 0.68 1.82e-45 Uric acid levels; CRC trans rs7647973 0.626 rs4855849 chr3:49653378 A/G cg21659725 chr3:3221576 CRBN -0.66 -7.31 -0.37 2.03e-12 Menarche (age at onset); CRC cis rs225245 0.765 rs226428 chr17:34049950 C/T cg05299278 chr17:33885742 SLFN14 -0.49 -7.97 -0.4 2.54e-14 Reticulocyte count;Reticulocyte fraction of red cells;High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells; CRC cis rs9916302 0.904 rs8076546 chr17:37555403 G/A cg00129232 chr17:37814104 STARD3 0.55 8.18 0.41 6.45e-15 Glomerular filtration rate (creatinine); CRC cis rs1451375 1.000 rs2329342 chr7:50624971 A/G cg18232548 chr7:50535776 DDC -0.46 -6.44 -0.33 4.14e-10 Malaria; CRC cis rs13191362 0.507 rs2155506 chr6:163035342 G/A cg21926612 chr6:163149169 PACRG;PARK2 -0.61 -9.64 -0.47 1.56e-19 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs12497850 0.931 rs6446205 chr3:49035211 C/T cg20833759 chr3:49053208 WDR6;DALRD3 0.53 9.15 0.45 6.02e-18 Parkinson's disease; CRC cis rs9487051 0.676 rs6568568 chr6:109597048 C/T cg12927641 chr6:109611667 NA -0.36 -6.44 -0.33 4.15e-10 Reticulocyte fraction of red cells; CRC cis rs3008870 1.000 rs3008848 chr1:67379284 C/T cg08660285 chr1:67390436 MIER1;WDR78 1.05 16.33 0.67 2.62e-44 Lymphocyte percentage of white cells; CRC cis rs780096 0.506 rs2303369 chr2:27715416 C/T cg27432699 chr2:27873401 GPN1 -0.62 -9.48 -0.46 5.39e-19 Total body bone mineral density; CRC cis rs7843479 0.601 rs4872207 chr8:21842751 C/G cg17168535 chr8:21777572 XPO7 -0.71 -12.42 -0.57 2.57e-29 Mean corpuscular volume; CRC cis rs28830936 1.000 rs112896623 chr15:42001845 C/T cg17847044 chr15:42102381 MAPKBP1 -0.3 -6.33 -0.33 7.94e-10 Diastolic blood pressure; CRC cis rs1387259 0.570 rs12368659 chr12:48562299 C/A cg24011408 chr12:48396354 COL2A1 0.44 6.56 0.34 2.05e-10 Obstructive sleep apnea trait (apnea hypopnea index); CRC cis rs17270561 0.609 rs9393662 chr6:25739670 T/C cg17691542 chr6:26056736 HIST1H1C 0.73 9.26 0.45 2.71e-18 Iron status biomarkers; CRC cis rs763121 0.853 rs6001191 chr22:39074452 T/C cg06544989 chr22:39130855 UNC84B 0.45 6.9 0.36 2.7e-11 Menopause (age at onset); CRC cis rs4474465 0.850 rs4482052 chr11:78263331 A/G cg27205649 chr11:78285834 NARS2 0.49 6.39 0.33 5.8e-10 Alzheimer's disease (survival time); CRC cis rs6952808 0.717 rs10950422 chr7:1926577 T/C cg14004847 chr7:1930337 MAD1L1 -0.49 -7.47 -0.38 7.39e-13 Bipolar disorder and schizophrenia; CRC cis rs4076764 0.958 rs11580702 chr1:163385523 C/G cg06092702 chr1:163392909 NA -0.55 -8.55 -0.43 4.6e-16 Motion sickness; CRC cis rs7918232 0.941 rs6482598 chr10:27426375 T/C cg14240646 chr10:27532245 ACBD5 -0.85 -9.81 -0.48 4.13e-20 Breast cancer; CRC cis rs6570726 0.537 rs1280279 chr6:145884048 G/T cg13319975 chr6:146136371 FBXO30 -0.6 -7.91 -0.4 3.96e-14 Lobe attachment (rater-scored or self-reported); CRC cis rs8049040 0.547 rs12929335 chr16:71435752 G/A cg08717414 chr16:71523259 ZNF19 -0.4 -5.63 -0.3 3.85e-8 Blood protein levels; CRC cis rs911186 0.812 rs6932590 chr6:27248931 T/C cg12292205 chr6:26970375 C6orf41 -0.62 -7.72 -0.39 1.37e-13 Autism spectrum disorder or schizophrenia; CRC cis rs1506636 0.646 rs805778 chr7:123214655 C/T cg03229431 chr7:123269106 ASB15 -0.59 -8.55 -0.43 4.56e-16 Plateletcrit;Platelet count; CRC cis rs898097 0.783 rs11650335 chr17:80835111 A/G cg15664640 chr17:80829946 TBCD -0.7 -11.77 -0.54 6.42e-27 Breast cancer; CRC cis rs6089584 0.528 rs881994 chr20:60623931 G/A cg06108461 chr20:60628389 TAF4 -0.74 -11.98 -0.55 1.09e-27 Body mass index; CRC cis rs897984 0.806 rs4889571 chr16:30949047 A/G cg02466173 chr16:30829666 NA 0.66 9.9 0.48 2.12e-20 Dementia with Lewy bodies; CRC cis rs9487051 0.872 rs7772602 chr6:109608661 C/G cg21918786 chr6:109611834 NA 0.44 8.13 0.41 8.84e-15 Reticulocyte fraction of red cells; CRC cis rs7811142 0.830 rs11761253 chr7:99939321 C/T cg00814883 chr7:100076585 TSC22D4 -0.68 -8.35 -0.42 1.94e-15 Platelet count; CRC cis rs7618915 0.501 rs6804145 chr3:52694198 C/T cg15147215 chr3:52552868 STAB1 -0.64 -11.07 -0.52 1.98e-24 Bipolar disorder; CRC cis rs1707322 0.752 rs28507722 chr1:46206540 A/G cg06784218 chr1:46089804 CCDC17 0.65 12.05 0.55 5.8e-28 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs8177253 0.965 rs1525889 chr3:133490033 A/C cg01448562 chr3:133502909 NA -0.53 -8.93 -0.44 3.14e-17 Iron status biomarkers; CRC cis rs801193 0.569 rs2659893 chr7:66199993 G/A cg18876405 chr7:65276391 NA 0.51 8.29 0.42 3.02e-15 Aortic root size; CRC cis rs4243830 0.850 rs10864612 chr1:6593830 C/G cg05709478 chr1:6581295 PLEKHG5 -0.56 -6.82 -0.35 4.36e-11 Body mass index; CRC cis rs4843747 0.671 rs28451517 chr16:88109127 A/C cg03395651 chr16:88107091 BANP 0.56 7.2 0.37 4.06e-12 Menopause (age at onset); CRC cis rs2882667 0.690 rs311601 chr5:138053386 G/A cg09476006 chr5:138032270 NA 0.61 10.01 0.48 8.97e-21 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs4728302 0.869 rs6955240 chr7:133581873 G/A cg10665199 chr7:133106180 EXOC4 0.4 6.11 0.32 2.89e-9 Intelligence;Intelligence (multi-trait analysis); CRC cis rs875971 0.862 rs778702 chr7:65864835 G/A cg00343986 chr7:65444356 GUSB 0.41 5.86 0.31 1.1e-8 Aortic root size; CRC cis rs7809950 0.678 rs7788330 chr7:106985648 G/T cg23024343 chr7:107201750 COG5 -0.75 -10.24 -0.49 1.5e-21 Coronary artery disease; CRC cis rs1707322 1.000 rs10890365 chr1:46359348 C/T cg03146154 chr1:46216737 IPP 0.51 7.0 0.36 1.48e-11 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs1150668 0.796 rs2531825 chr6:28349264 C/T cg21251018 chr6:28226885 NKAPL 0.46 7.93 0.4 3.41e-14 Pubertal anthropometrics; CRC cis rs3936840 0.539 rs3742445 chr14:102975552 T/A cg18135206 chr14:102964638 TECPR2 0.58 7.33 0.37 1.85e-12 Plateletcrit; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg02993250 chr10:5726650 C10orf18 0.41 6.03 0.32 4.43e-9 Response to antipsychotic treatment; CRC cis rs6088580 0.609 rs6058029 chr20:32969643 T/C cg24642439 chr20:33292090 TP53INP2 -0.38 -6.41 -0.33 5.08e-10 Glomerular filtration rate (creatinine); CRC trans rs1997103 1.000 rs2331067 chr7:55408232 A/T cg20935933 chr6:143382018 AIG1 0.51 6.65 0.34 1.25e-10 QRS interval (sulfonylurea treatment interaction); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg00127732 chr19:42757846 ERF 0.43 6.08 0.32 3.38e-9 Intelligence (multi-trait analysis); CRC cis rs17376456 0.825 rs10051878 chr5:93064164 T/G cg21475434 chr5:93447410 FAM172A 0.73 7.27 0.37 2.6e-12 Diabetic retinopathy; CRC cis rs4363385 0.510 rs6673356 chr1:153041903 C/T cg25856811 chr1:152973957 SPRR3 0.21 5.9 0.31 8.92e-9 Inflammatory skin disease; CRC cis rs28386778 0.897 rs968719 chr17:61908271 C/T cg06601766 chr17:61851465 DDX42;CCDC47 0.47 6.02 0.31 4.74e-9 Prudent dietary pattern; CRC cis rs6951245 0.832 rs79808627 chr7:1092519 C/G cg22907277 chr7:1156413 C7orf50 0.52 5.94 0.31 7.38e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs9905704 0.918 rs2611783 chr17:56808530 A/G cg12560992 chr17:57184187 TRIM37 0.53 7.37 0.38 1.41e-12 Testicular germ cell tumor; CRC cis rs10504229 0.728 rs17215676 chr8:58152915 G/T cg21724239 chr8:58056113 NA 0.62 8.38 0.42 1.51e-15 Developmental language disorder (linguistic errors); CRC cis rs1552244 1.000 rs4260416 chr3:10125283 C/T cg16606324 chr3:10149918 C3orf24 0.71 9.83 0.48 3.77e-20 Alzheimer's disease; CRC cis rs7927592 0.763 rs596494 chr11:68251054 T/G cg16797656 chr11:68205561 LRP5 0.49 8.99 0.44 1.92e-17 Total body bone mineral density; CRC cis rs1568889 0.730 rs6484350 chr11:28113658 G/A cg06544937 chr11:28130018 METT5D1;KIF18A -0.9 -15.19 -0.64 7.23e-40 Bipolar disorder; CRC cis rs7666738 0.830 rs7691433 chr4:98968118 A/T cg05340658 chr4:99064831 C4orf37 0.6 9.16 0.45 5.78e-18 Colonoscopy-negative controls vs population controls; CRC cis rs6663390 0.831 rs3754172 chr1:208086878 G/T cg03990033 chr1:208084030 CD34 0.47 6.63 0.34 1.39e-10 Facial morphology (factor 18); CRC cis rs7937682 0.847 rs500163 chr11:111462649 T/G cg19812747 chr11:111475976 SIK2 -0.57 -9.72 -0.47 8.51e-20 Primary sclerosing cholangitis; CRC cis rs1577917 0.739 rs6922 chr6:86205323 T/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A 0.67 8.79 0.44 8.52e-17 Response to antipsychotic treatment; CRC cis rs4713118 0.824 rs2092075 chr6:27749330 G/C cg15786705 chr6:28176104 NA 0.54 7.06 0.36 1.01e-11 Parkinson's disease; CRC cis rs637571 0.654 rs1058068 chr11:65667796 G/A cg26695010 chr11:65641043 EFEMP2 -0.44 -6.42 -0.33 4.78e-10 Eosinophil percentage of white cells; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg09458940 chr7:23145311 KLHL7 0.46 6.31 0.33 9.2e-10 Anxiety disorder; CRC cis rs875971 1.000 rs2087647 chr7:65593188 C/A cg00343986 chr7:65444356 GUSB -0.45 -6.64 -0.34 1.27e-10 Aortic root size; CRC cis rs7772486 0.654 rs702321 chr6:146006695 A/G cg23711669 chr6:146136114 FBXO30 -0.66 -11.05 -0.52 2.28e-24 Lobe attachment (rater-scored or self-reported); CRC cis rs62064224 0.714 rs62064225 chr17:30635429 C/T cg12855166 chr17:30846586 MYO1D -0.38 -6.44 -0.33 4.27e-10 Schizophrenia; CRC cis rs7264396 0.563 rs2425094 chr20:34306974 G/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.48 -6.67 -0.35 1.06e-10 Total cholesterol levels; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg19875976 chr9:114246783 KIAA0368 0.46 6.5 0.34 2.99e-10 Response to antipsychotic treatment; CRC cis rs12477438 0.765 rs4374423 chr2:99662348 G/A cg14399236 chr2:99771627 LIPT1;TSGA10 -0.6 -8.19 -0.41 6.03e-15 Chronic sinus infection; CRC cis rs854765 0.647 rs854790 chr17:18028318 C/G cg04398451 chr17:18023971 MYO15A -0.59 -10.16 -0.49 2.85e-21 Total body bone mineral density; CRC cis rs6120849 0.754 rs6120819 chr20:33653038 T/C cg08999081 chr20:33150536 PIGU 0.43 5.64 0.3 3.69e-8 Protein C levels; CRC cis rs1506636 0.889 rs619075 chr7:123426317 A/T cg03229431 chr7:123269106 ASB15 0.73 11.63 0.54 1.97e-26 Plateletcrit;Platelet count; CRC trans rs2727020 0.576 rs11040223 chr11:49034633 G/T cg21153622 chr11:89784906 NA -0.55 -9.25 -0.45 2.9e-18 Coronary artery disease; CRC cis rs6502050 0.835 rs9904520 chr17:80100117 T/C cg11859384 chr17:80120422 CCDC57 -0.37 -5.85 -0.31 1.16e-8 Life satisfaction; CRC cis rs7680126 0.500 rs4697717 chr4:10149784 C/G cg11266682 chr4:10021025 SLC2A9 -0.42 -6.16 -0.32 2.1e-9 Urate levels in lean individuals;Urate levels in overweight individuals;Urate levels in obese individuals; CRC cis rs7618915 0.571 rs17264436 chr3:52610651 T/A cg07507251 chr3:52567010 NT5DC2 0.46 6.73 0.35 7.48e-11 Bipolar disorder; CRC cis rs1799949 1.000 rs4793192 chr17:41204390 T/C cg01879757 chr17:41196368 BRCA1 -0.41 -6.26 -0.33 1.24e-9 Menopause (age at onset); CRC cis rs1267303 0.642 rs7542296 chr1:46998009 A/G cg08533674 chr1:46993347 NA -0.67 -9.12 -0.45 7.82e-18 Monobrow; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg27330692 chr10:72972192 UNC5B 0.44 6.02 0.31 4.54e-9 Anxiety disorder; CRC cis rs9534288 0.702 rs7331472 chr13:46644173 C/T cg15192986 chr13:46630673 CPB2 -0.73 -9.62 -0.47 1.84e-19 Blood protein levels; CRC cis rs853679 0.517 rs2275508 chr6:28094731 T/C cg12963246 chr6:28129442 ZNF389 0.5 5.98 0.31 5.71e-9 Depression; CRC cis rs79387448 0.638 rs116055209 chr2:103032189 C/T cg00507830 chr2:103233733 NA 0.55 5.79 0.3 1.64e-8 Gut microbiota (bacterial taxa); CRC cis rs2576037 0.526 rs4890699 chr18:44541029 T/C cg24750912 chr18:44543259 TCEB3CL;KATNAL2 0.32 6.35 0.33 7.15e-10 Personality dimensions; CRC cis rs2239547 0.522 rs2581823 chr3:53022076 C/G cg18404041 chr3:52824283 ITIH1 0.39 7.53 0.38 4.81e-13 Schizophrenia; CRC cis rs2228479 0.850 rs11645916 chr16:89835234 G/A cg06656553 chr16:89960601 TCF25 -0.7 -5.82 -0.31 1.37e-8 Skin colour saturation; CRC cis rs7762018 1.000 rs6942332 chr6:170131934 A/G cg24289452 chr6:170231220 NA -0.57 -6.49 -0.34 3.12e-10 Thiazide-induced adverse metabolic effects in hypertensive patients; CRC cis rs11098499 0.913 rs13126596 chr4:120140729 A/G cg24375607 chr4:120327624 NA 0.48 7.44 0.38 8.67e-13 Corneal astigmatism; CRC cis rs10504229 0.512 rs117968470 chr8:58014651 C/G cg08219700 chr8:58056026 NA 0.55 6.5 0.34 2.99e-10 Developmental language disorder (linguistic errors); CRC cis rs9811920 0.609 rs2452320 chr3:99645216 G/A cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G 0.46 6.18 0.32 1.87e-9 Axial length; CRC trans rs12478296 1.000 rs55732177 chr2:243040006 C/T cg18288967 chr1:45987694 PRDX1 0.68 7.48 0.38 6.93e-13 Obesity-related traits; CRC cis rs796364 1.000 rs35594306 chr2:200775125 T/C cg25936922 chr2:200820526 C2orf60;C2orf47 -0.77 -7.36 -0.38 1.51e-12 Schizophrenia; CRC cis rs910316 1.000 rs7142235 chr14:75559963 T/C cg11812906 chr14:75593930 NEK9 0.63 10.34 0.5 7.15e-22 Height; CRC cis rs7677751 0.767 rs6832597 chr4:55076237 C/A cg13615338 chr4:55094005 PDGFRA 0.41 6.02 0.31 4.77e-9 Corneal astigmatism; CRC cis rs7615952 0.512 rs1077621 chr3:125819799 A/G cg04553112 chr3:125709451 NA -0.52 -5.97 -0.31 6.13e-9 Blood pressure (smoking interaction); CRC trans rs2303319 0.504 rs62188988 chr2:162531068 T/C cg06896663 chr8:82754093 SNX16 -0.69 -6.17 -0.32 2.01e-9 Cognitive function; CRC cis rs28386778 0.829 rs1877317 chr17:61776479 T/C cg06601766 chr17:61851465 DDX42;CCDC47 0.44 5.8 0.3 1.54e-8 Prudent dietary pattern; CRC trans rs2727020 0.786 rs10839263 chr11:49354462 A/G cg03929089 chr4:120376271 NA -0.7 -9.27 -0.46 2.55e-18 Coronary artery disease; CRC cis rs7208859 0.623 rs12103440 chr17:29086657 A/G cg01831904 chr17:28903510 LRRC37B2 -0.63 -6.45 -0.33 4.07e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs7809950 0.954 rs2189839 chr7:107230026 A/G cg23024343 chr7:107201750 COG5 0.59 8.64 0.43 2.43e-16 Coronary artery disease; CRC cis rs9462027 0.628 rs7771778 chr6:34660324 C/T cg07306190 chr6:34760872 UHRF1BP1 0.35 6.32 0.33 8.42e-10 Systemic lupus erythematosus; CRC cis rs921968 0.643 rs1055816 chr2:219501328 G/A cg02176678 chr2:219576539 TTLL4 0.5 7.98 0.4 2.44e-14 Mean corpuscular hemoglobin concentration; CRC cis rs4713118 0.615 rs9295747 chr6:27736993 G/T cg26587870 chr6:27730563 NA 0.39 6.1 0.32 2.97e-9 Parkinson's disease; CRC cis rs4757319 0.515 rs12809040 chr11:15431903 G/A cg03245590 chr11:15329459 NA 0.53 9.25 0.45 2.89e-18 Breast cancer; CRC cis rs7264396 0.563 rs6060580 chr20:34310512 T/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.49 -6.72 -0.35 7.9e-11 Total cholesterol levels; CRC cis rs7274811 0.779 rs34145153 chr20:32159067 C/T cg03904042 chr20:32255491 NECAB3;C20orf134 -0.47 -6.52 -0.34 2.57e-10 Height; CRC cis rs7927771 0.965 rs35985502 chr11:47847428 G/A cg18512352 chr11:47633146 NA -0.48 -9.4 -0.46 9.71e-19 Subjective well-being; CRC cis rs4588572 0.643 rs9293752 chr5:77798432 A/G cg11547950 chr5:77652471 NA 0.44 6.52 0.34 2.6200000000000003e-10 Triglycerides; CRC cis rs9393692 0.557 rs12660432 chr6:26317384 C/T cg13736514 chr6:26305472 NA -0.45 -7.24 -0.37 3.18e-12 Educational attainment; CRC cis rs1448094 0.512 rs1584368 chr12:86245117 A/C cg25456477 chr12:86230367 RASSF9 0.33 5.82 0.31 1.43e-8 Major depressive disorder; CRC trans rs7301826 0.627 rs7315707 chr12:131272819 A/G cg14491479 chr8:144623711 ZC3H3 0.47 6.24 0.33 1.38e-9 Plasma plasminogen activator levels; CRC cis rs9914988 0.943 rs4795465 chr17:27151498 A/G cg07195577 chr17:27052828 TLCD1 -0.39 -5.6 -0.3 4.52e-8 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs904251 0.965 rs62406516 chr6:37439364 C/T cg25019722 chr6:37503610 NA -0.37 -6.53 -0.34 2.57e-10 Cognitive performance; CRC trans rs2303319 0.504 rs12467625 chr2:162603387 C/A cg22922770 chr7:98923339 ARPC1A -0.67 -5.98 -0.31 5.68e-9 Cognitive function; CRC cis rs875971 0.862 rs10950033 chr7:65739673 A/G cg12463550 chr7:65579703 CRCP -0.53 -7.42 -0.38 9.97e-13 Aortic root size; CRC cis rs977987 0.872 rs2161648 chr16:75314629 T/G cg03315344 chr16:75512273 CHST6 0.54 9.16 0.45 5.81e-18 Dupuytren's disease; CRC trans rs61101201 0.962 rs10835790 chr11:31610022 C/T cg08676242 chr7:75616848 TMEM120A 0.53 6.57 0.34 1.95e-10 Optic disc area; CRC cis rs57221529 1.000 rs57221529 chr5:586624 A/G cg17948913 chr5:572064 NA 0.52 6.0 0.31 5.1e-9 Lung disease severity in cystic fibrosis; CRC cis rs3785574 0.962 rs2584628 chr17:61894578 T/C cg06601766 chr17:61851465 DDX42;CCDC47 0.6 8.37 0.42 1.63e-15 Height; CRC cis rs9911578 1.000 rs9902994 chr17:56948722 T/A cg12560992 chr17:57184187 TRIM37 0.92 17.0 0.68 6.03e-47 Intelligence (multi-trait analysis); CRC cis rs796364 0.806 rs11674293 chr2:201026743 G/A cg25936922 chr2:200820526 C2orf60;C2orf47 -0.65 -5.84 -0.31 1.27e-8 Schizophrenia; CRC cis rs9393692 0.620 rs4412193 chr6:26338056 A/G cg13736514 chr6:26305472 NA -0.47 -7.63 -0.39 2.61e-13 Educational attainment; CRC cis rs3768617 0.811 rs11590958 chr1:183023636 T/C ch.1.3577855R chr1:183094577 LAMC1 0.61 8.96 0.44 2.39e-17 Fuchs's corneal dystrophy; CRC cis rs6942756 0.876 rs822040 chr7:129065922 C/G cg02491457 chr7:128862824 NA 0.59 7.9 0.4 4.18e-14 White matter hyperintensity burden; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg11820497 chr19:10654946 ATG4D 0.46 6.39 0.33 5.69e-10 Response to antipsychotic treatment; CRC cis rs7666738 0.716 rs114187620 chr4:98819534 T/A cg05340658 chr4:99064831 C4orf37 0.54 7.74 0.39 1.19e-13 Colonoscopy-negative controls vs population controls; CRC cis rs1153858 1.000 rs3759899 chr15:45655903 T/C cg14582100 chr15:45693742 SPATA5L1 0.29 6.05 0.32 3.91e-9 Homoarginine levels; CRC trans rs2727020 0.675 rs7929401 chr11:49350832 C/A cg03929089 chr4:120376271 NA -0.64 -7.92 -0.4 3.61e-14 Coronary artery disease; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg02067639 chr14:71067412 MED6 0.41 6.56 0.34 2.1e-10 Liver disease severity in Alagille syndrome; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg22800332 chr5:138775207 DNAJC18 0.46 6.05 0.32 3.92e-9 Thyroid stimulating hormone; CRC cis rs10504229 0.683 rs17194792 chr8:58107195 A/C cg02290350 chr8:58132656 NA -0.6 -6.78 -0.35 5.45e-11 Developmental language disorder (linguistic errors); CRC cis rs10493773 0.775 rs11161649 chr1:86165446 A/C cg17807903 chr1:86174739 ZNHIT6 -0.52 -11.7 -0.54 1.14e-26 Urate levels in overweight individuals; CRC cis rs3018066 0.748 rs6846579 chr4:107011756 A/G cg01869342 chr4:106983673 TBCK 0.46 6.8 0.35 5.08e-11 Cancer; CRC cis rs6500602 0.701 rs4785969 chr16:4536934 A/T cg06139259 chr16:4526053 HMOX2;NMRAL1 0.57 7.57 0.39 3.81e-13 Schizophrenia; CRC trans rs2303319 0.582 rs62188151 chr2:162309849 C/A cg04145477 chr6:107077629 RTN4IP1;QRSL1 -0.84 -6.27 -0.33 1.13e-9 Cognitive function; CRC cis rs172166 0.637 rs1233691 chr6:28153897 T/G cg12273811 chr6:28175739 NA 0.67 10.31 0.49 8.63e-22 Cardiac Troponin-T levels; CRC cis rs274567 0.501 rs581968 chr5:131710202 G/A cg24060327 chr5:131705240 SLC22A5 0.54 8.01 0.4 2e-14 Blood metabolite levels; CRC cis rs727505 1.000 rs68091803 chr7:124526331 C/T cg23710748 chr7:124431027 NA -0.85 -15.05 -0.64 2.7e-39 Lewy body disease; CRC cis rs7937682 0.632 rs4935811 chr11:111679262 C/T cg19812747 chr11:111475976 SIK2 0.44 6.43 0.33 4.54e-10 Primary sclerosing cholangitis; CRC cis rs9914988 0.887 rs12948575 chr17:27130520 G/A cg12682573 chr17:27188876 MIR451;MIR144 0.58 7.99 0.4 2.37e-14 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC trans rs2727020 0.521 rs11040408 chr11:49534880 A/T cg03929089 chr4:120376271 NA 0.76 10.53 0.5 1.52e-22 Coronary artery disease; CRC cis rs965469 1.000 rs965469 chr20:3381549 T/C cg25506879 chr20:3388711 C20orf194 -0.39 -5.75 -0.3 1.99e-8 IFN-related cytopenia; CRC cis rs6502050 0.769 rs4789741 chr17:80119184 A/C cg02741985 chr17:80059408 CCDC57 0.44 7.2 0.37 4.08e-12 Life satisfaction; CRC trans rs1814175 0.817 rs7109440 chr11:49966296 C/T cg11707556 chr5:10655725 ANKRD33B -0.43 -8.01 -0.4 2.01e-14 Height; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg22885777 chr19:15947555 NA 0.46 7.5 0.38 6.12e-13 Liver disease severity in Alagille syndrome; CRC cis rs2032447 0.670 rs198848 chr6:26106325 A/G cg12310025 chr6:25882481 NA -0.43 -6.1 -0.32 3e-9 Intelligence (multi-trait analysis); CRC cis rs5750830 0.649 rs4821895 chr22:39823015 A/G cg11247378 chr22:39784982 NA -0.47 -9.27 -0.46 2.56e-18 Intelligence (multi-trait analysis); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg17608500 chr1:154955711 FLAD1 0.43 6.02 0.31 4.75e-9 Response to antipsychotic treatment; CRC cis rs780096 0.525 rs13388159 chr2:27648284 A/T cg24768116 chr2:27665128 KRTCAP3 -0.35 -7.75 -0.39 1.12e-13 Total body bone mineral density; CRC cis rs9847710 0.869 rs2581793 chr3:53035655 G/A cg04503182 chr3:53078218 SFMBT1 0.38 6.01 0.31 4.88e-9 Ulcerative colitis; CRC cis rs861020 0.771 rs674804 chr1:210014603 C/G cg09163369 chr1:210001066 C1orf107 0.61 8.03 0.41 1.7e-14 Orofacial clefts; CRC cis rs7487075 0.619 rs67249026 chr12:46835768 T/C cg22049899 chr12:47219821 SLC38A4 0.31 5.75 0.3 2.08e-8 Itch intensity from mosquito bite; CRC cis rs7635838 0.929 rs7638724 chr3:11413387 T/G cg00170343 chr3:11313890 ATG7 0.42 6.37 0.33 6.44e-10 HDL cholesterol; CRC cis rs9372498 0.536 rs62422235 chr6:118971913 G/A cg15382696 chr6:118971807 C6orf204 0.57 6.84 0.35 3.94e-11 Diastolic blood pressure; CRC cis rs7715806 0.500 rs4704233 chr5:75000792 G/A cg19683494 chr5:74908142 NA 0.56 6.38 0.33 6.09e-10 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs28386778 0.897 rs10221279 chr17:61806138 A/G cg06601766 chr17:61851465 DDX42;CCDC47 0.44 5.97 0.31 6.3e-9 Prudent dietary pattern; CRC cis rs2816062 0.965 rs2816061 chr1:18903819 A/G cg18795169 chr1:18902165 NA 0.85 16.77 0.68 4.59e-46 Urate levels in lean individuals; CRC cis rs9910055 0.718 rs2526022 chr17:42213216 C/T cg16434002 chr17:42200994 HDAC5 -0.45 -6.12 -0.32 2.66e-9 Total body bone mineral density; CRC cis rs1728785 1.000 rs864741 chr16:68576577 C/T cg02972257 chr16:68554789 NA -0.58 -7.23 -0.37 3.4e-12 Ulcerative colitis; CRC cis rs7927592 0.956 rs10896343 chr11:68317860 G/C cg16797656 chr11:68205561 LRP5 0.36 5.61 0.3 4.23e-8 Total body bone mineral density; CRC cis rs11785693 0.862 rs17351027 chr8:4987098 A/G cg26367366 chr8:4980734 NA -0.76 -9.63 -0.47 1.7e-19 Neuroticism (multi-trait analysis);Neuroticism; CRC cis rs1707322 1.000 rs785507 chr1:46541558 C/T cg03146154 chr1:46216737 IPP -0.57 -7.57 -0.38 3.9e-13 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs2019137 0.936 rs902696 chr2:113954879 G/T cg21482265 chr2:113992762 PAX8;LOC440839;LOC654433 0.46 6.44 0.33 4.13e-10 Lymphocyte counts; CRC cis rs10791323 0.575 rs4489760 chr11:133732265 A/T cg06766960 chr11:133703094 NA -0.41 -7.3 -0.37 2.22e-12 Childhood ear infection; CRC cis rs10911251 0.508 rs2245784 chr1:183107665 G/A ch.1.3577855R chr1:183094577 LAMC1 0.82 14.03 0.61 2.24e-35 Colorectal cancer; CRC trans rs11098499 0.954 rs59394118 chr4:120295551 A/G cg25214090 chr10:38739885 LOC399744 0.63 9.77 0.47 5.88e-20 Corneal astigmatism; CRC cis rs1799949 0.965 rs6503727 chr17:41312859 C/T cg19454999 chr17:41278357 BRCA1;NBR2 0.39 6.15 0.32 2.24e-9 Menopause (age at onset); CRC cis rs11148252 0.553 rs2147692 chr13:53287023 C/G cg00495681 chr13:53174319 NA 0.87 16.86 0.68 2.15e-46 Lewy body disease; CRC cis rs4474465 1.000 rs7935180 chr11:78169785 C/T cg27205649 chr11:78285834 NARS2 -0.48 -5.85 -0.31 1.18e-8 Alzheimer's disease (survival time); CRC cis rs4409675 0.619 rs12070173 chr1:28231955 G/C cg23691781 chr1:28212827 C1orf38 0.31 7.17 0.37 4.98e-12 Corneal astigmatism; CRC cis rs4889855 0.556 rs11547301 chr17:78518780 C/T cg16591659 chr17:78472290 NA 0.41 5.87 0.31 1.08e-8 Fractional excretion of uric acid; CRC cis rs9419702 0.568 rs7075233 chr10:133545170 A/G cg04492858 chr10:133558786 NA -0.38 -6.18 -0.32 1.9e-9 Survival in rectal cancer; CRC cis rs10751667 0.666 rs7395402 chr11:950293 A/G cg23136738 chr11:925521 AP2A2 0.42 7.2 0.37 4.16e-12 Alzheimer's disease (late onset); CRC cis rs78456975 1.000 rs4073861 chr2:1563611 G/A cg12573674 chr2:1569213 NA -0.78 -8.11 -0.41 1.02e-14 Placebo response in major depressive disorder (% change in symptom score); CRC cis rs11098499 1.000 rs6849889 chr4:120186348 A/C cg24375607 chr4:120327624 NA 0.43 6.68 0.35 1.03e-10 Corneal astigmatism; CRC trans rs11098499 0.954 rs10031483 chr4:120422636 T/C cg25214090 chr10:38739885 LOC399744 0.65 10.13 0.49 3.7e-21 Corneal astigmatism; CRC cis rs7638909 0.512 rs11720166 chr3:38599812 C/G cg01465620 chr3:38496096 LOC100128640;ACVR2B -0.5 -7.16 -0.37 5.37e-12 Electrocardiographic conduction measures; CRC cis rs1784581 0.674 rs3016555 chr6:162391421 T/C cg17173639 chr6:162384350 PARK2 -0.7 -11.86 -0.55 2.94e-27 Itch intensity from mosquito bite; CRC cis rs2404602 0.647 rs35940181 chr15:77180019 G/A cg23625390 chr15:77176239 SCAPER -0.84 -13.3 -0.59 1.4e-32 Blood metabolite levels; CRC cis rs7945705 0.935 rs10769971 chr11:8925276 C/T cg00186954 chr11:8933980 ST5;C11orf17 0.46 7.07 0.36 9.28e-12 Hemoglobin concentration; CRC cis rs12477438 1.000 rs1922624 chr2:99909958 A/G cg26064155 chr2:99771622 LIPT1;TSGA10 -0.76 -9.5 -0.46 4.43e-19 Chronic sinus infection; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg10869376 chr13:41345315 MRPS31 0.45 6.36 0.33 6.69e-10 Response to antipsychotic treatment; CRC cis rs780096 0.587 rs6760828 chr2:27579231 T/C cg02592271 chr2:27665507 KRTCAP3 -0.26 -5.84 -0.31 1.22e-8 Total body bone mineral density; CRC trans rs800082 1.000 rs28847402 chr3:144316893 C/G cg24215973 chr2:240111563 HDAC4 -0.52 -6.95 -0.36 1.95e-11 Smoking behavior; CRC cis rs597539 0.652 rs611046 chr11:68631704 A/G cg06112835 chr11:68658793 MRPL21 0.39 6.03 0.32 4.36e-9 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs6582630 0.560 rs12315134 chr12:38419857 T/A cg26384229 chr12:38710491 ALG10B -0.52 -7.51 -0.38 5.69e-13 Drug-induced liver injury (flucloxacillin); CRC cis rs1215050 0.743 rs6532692 chr4:98648005 C/A cg05340658 chr4:99064831 C4orf37 -0.46 -6.85 -0.35 3.65e-11 Waist-to-hip ratio adjusted for body mass index; CRC cis rs681343 1.000 rs516316 chr19:49206145 C/G cg21064579 chr19:49206444 FUT2 0.52 9.19 0.45 4.67e-18 Lung adenocarcinoma;Primary sclerosing cholangitis;Childhood ear infection; CRC cis rs11583043 0.958 rs11583674 chr1:101396560 C/G cg16556008 chr1:101360663 SLC30A7;EXTL2 0.57 7.73 0.39 1.35e-13 Ulcerative colitis;Inflammatory bowel disease; CRC cis rs1983170 0.735 rs963910 chr1:92014136 T/C cg02896835 chr1:92012615 NA -0.49 -7.15 -0.37 5.52e-12 Eosinophil percentage of white cells; CRC cis rs7144547 0.950 rs8004137 chr14:81884857 A/G cg02996355 chr14:81879375 NA -0.72 -11.11 -0.52 1.43e-24 Prudent dietary pattern; CRC cis rs904251 0.766 rs1757175 chr6:37486694 T/C cg01843034 chr6:37503916 NA -0.48 -8.8 -0.44 7.73e-17 Cognitive performance; CRC cis rs1865760 0.613 rs7749342 chr6:25920265 T/C cg03264133 chr6:25882463 NA -0.45 -6.7 -0.35 9e-11 Height; CRC cis rs12497850 0.864 rs4955410 chr3:49181218 A/G cg07636037 chr3:49044803 WDR6 0.92 14.66 0.63 8.32e-38 Parkinson's disease; CRC cis rs9807989 0.507 rs4851579 chr2:103028984 G/A cg03938978 chr2:103052716 IL18RAP 0.59 10.13 0.49 3.5e-21 Asthma; CRC cis rs12594515 1.000 rs6493172 chr15:45987213 T/G cg06207120 chr15:45996521 NA 0.32 7.75 0.39 1.16e-13 Waist circumference;Weight; CRC cis rs13108904 0.967 rs4405964 chr4:1278814 A/G cg00684032 chr4:1343700 KIAA1530 0.49 7.25 0.37 3.04e-12 Obesity-related traits; CRC cis rs2153535 0.601 rs2143352 chr6:8530248 G/C cg21535247 chr6:8435926 SLC35B3 0.48 7.33 0.37 1.81e-12 Motion sickness; CRC trans rs11039798 0.620 rs10838833 chr11:48238880 C/T cg15704280 chr7:45808275 SEPT13 0.69 6.73 0.35 7.46e-11 Axial length; CRC cis rs4964805 0.770 rs11111779 chr12:104185496 G/A cg02344784 chr12:104178138 NT5DC3 0.57 8.91 0.44 3.43e-17 Attention deficit hyperactivity disorder; CRC cis rs40363 0.680 rs4010628 chr16:3529779 G/A cg22508957 chr16:3507546 NAT15 0.7 7.04 0.36 1.11e-11 Tuberculosis; CRC cis rs9916302 0.904 rs679995 chr17:37441679 A/T cg15445000 chr17:37608096 MED1 -0.42 -9.05 -0.45 1.32e-17 Glomerular filtration rate (creatinine); CRC cis rs2404602 0.684 rs28895952 chr15:76856776 A/G cg03037974 chr15:76606532 NA -0.51 -7.59 -0.39 3.28e-13 Blood metabolite levels; CRC cis rs898097 0.510 rs10445242 chr17:80891666 G/T cg15369054 chr17:80825471 TBCD -0.35 -5.87 -0.31 1.07e-8 Breast cancer; CRC cis rs10782582 0.593 rs11576534 chr1:76112751 C/T cg03433033 chr1:76189801 ACADM -0.45 -6.56 -0.34 2.13e-10 Daytime sleep phenotypes; CRC cis rs861020 0.630 rs628300 chr1:209998298 C/T cg09163369 chr1:210001066 C1orf107 0.5 7.02 0.36 1.26e-11 Orofacial clefts; CRC trans rs1814175 0.645 rs1721995 chr11:49915488 A/G cg15704280 chr7:45808275 SEPT13 -0.94 -16.66 -0.68 1.23e-45 Height; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg20284218 chr11:62648405 SLC3A2 0.41 6.29 0.33 1.02e-9 Liver disease severity in Alagille syndrome; CRC cis rs2795502 1.000 rs2142991 chr10:43341105 C/T cg20628663 chr10:43360327 NA -0.69 -10.8 -0.51 1.83e-23 Blood protein levels; CRC cis rs10504229 0.815 rs75577263 chr8:58188434 A/G cg22535103 chr8:58192502 C8orf71 -0.82 -12.27 -0.56 9.63e-29 Developmental language disorder (linguistic errors); CRC trans rs11039798 0.623 rs588700 chr11:48449889 T/C cg03929089 chr4:120376271 NA -0.64 -6.59 -0.34 1.74e-10 Axial length; CRC cis rs9640161 0.658 rs60467296 chr7:150015471 G/A cg13722127 chr7:150037890 RARRES2 0.47 7.34 0.37 1.74e-12 Blood protein levels;Circulating chemerin levels; CRC cis rs908922 0.676 rs7518654 chr1:152517845 C/G cg23254163 chr1:152506842 NA 0.43 8.51 0.42 6.08e-16 Hair morphology; CRC cis rs2153535 0.580 rs9378551 chr6:8463744 A/G cg07606381 chr6:8435919 SLC35B3 0.68 10.9 0.51 8.26e-24 Motion sickness; CRC cis rs208520 1.000 rs12194996 chr6:66973366 G/C cg07460842 chr6:66804631 NA 0.89 10.75 0.51 2.56e-23 Exhaled nitric oxide output; CRC trans rs3942852 0.910 rs10742831 chr11:48119691 G/A cg03929089 chr4:120376271 NA -0.58 -6.94 -0.36 2.09e-11 Acute lymphoblastic leukemia (childhood); CRC cis rs870825 0.549 rs10015956 chr4:185614705 T/C cg04058563 chr4:185651563 MLF1IP 0.71 9.02 0.45 1.56e-17 Blood protein levels; CRC cis rs427941 0.703 rs201443 chr7:101737688 A/T cg06246474 chr7:101738831 CUX1 0.45 7.06 0.36 9.64e-12 Plasma omega-3 polyunsaturated fatty acid level (eicosapentaenoic acid); CRC cis rs6921919 0.583 rs7759191 chr6:28353434 A/C cg21251018 chr6:28226885 NKAPL 0.4 6.11 0.32 2.83e-9 Autism spectrum disorder or schizophrenia; CRC cis rs9399135 0.967 rs2327578 chr6:135329969 C/T cg22676075 chr6:135203613 NA 0.42 6.49 0.34 3.24e-10 Red blood cell count; CRC cis rs55794721 0.509 rs12027110 chr1:25775682 A/T cg20684491 chr1:25596433 NA 0.45 7.96 0.4 2.75e-14 Plateletcrit;Mean corpuscular volume; CRC cis rs7605827 0.930 rs1473178 chr2:15576750 T/C cg19274914 chr2:15703543 NA 0.39 6.02 0.31 4.78e-9 Educational attainment (years of education); CRC trans rs1455244 0.700 rs7229302 chr18:11508904 G/T cg24181213 chr8:82586475 IMPA1 -0.37 -5.98 -0.31 5.89e-9 Schizophrenia; CRC cis rs736408 0.609 rs13082960 chr3:52785168 A/C cg10712668 chr3:52740153 GLT8D1;SPCS1 0.38 5.62 0.3 3.97e-8 Bipolar disorder; CRC cis rs3785574 0.962 rs2727324 chr17:61922102 G/C cg06873352 chr17:61820015 STRADA 0.48 7.62 0.39 2.65e-13 Height; CRC cis rs7586879 1.000 rs10175064 chr2:25117537 T/C cg22495460 chr2:25135724 ADCY3 -0.73 -11.97 -0.55 1.19e-27 Body mass index; CRC cis rs9914988 0.778 rs9907185 chr17:27122414 C/T cg16670446 chr17:27188758 MIR451;MIR144 0.55 8.52 0.43 5.75e-16 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs10256972 0.641 rs12702017 chr7:1129413 C/T cg09177884 chr7:1199841 ZFAND2A -0.41 -5.84 -0.31 1.23e-8 Longevity;Endometriosis; CRC cis rs938554 0.784 rs10939638 chr4:9977675 T/A cg11266682 chr4:10021025 SLC2A9 0.35 5.64 0.3 3.62e-8 Blood metabolite levels; CRC cis rs7937682 0.921 rs10891280 chr11:111433609 A/T cg09085632 chr11:111637200 PPP2R1B 0.94 15.0 0.64 3.89e-39 Primary sclerosing cholangitis; CRC cis rs10504229 0.775 rs17804840 chr8:58157045 C/T cg24829409 chr8:58192753 C8orf71 -0.6 -8.07 -0.41 1.29e-14 Developmental language disorder (linguistic errors); CRC cis rs2075371 0.835 rs1646724 chr7:134001875 T/G cg02659138 chr7:134003124 SLC35B4 0.4 6.97 0.36 1.71e-11 Mean platelet volume; CRC trans rs7824557 0.583 rs6601585 chr8:11233659 A/G cg06636001 chr8:8085503 FLJ10661 -0.5 -7.5 -0.38 6.17e-13 Retinal vascular caliber; CRC cis rs4713118 0.911 rs9461406 chr6:27719764 C/T cg25164649 chr6:28176230 NA -0.61 -7.6 -0.39 3.1400000000000003e-13 Parkinson's disease; CRC cis rs6502050 0.799 rs4482345 chr17:80152919 G/A cg13198984 chr17:80129470 CCDC57 0.44 7.83 0.4 6.88e-14 Life satisfaction; CRC cis rs9399135 0.935 rs11754504 chr6:135321509 C/T cg24558204 chr6:135376177 HBS1L 0.51 8.11 0.41 1.01e-14 Red blood cell count; CRC cis rs13064411 0.696 rs1486894 chr3:113211513 G/A cg10517650 chr3:113235015 CCDC52 -0.41 -7.18 -0.37 4.55e-12 Response to simvastatin treatment (PCSK9 protein level change); CRC cis rs10870270 0.957 rs3753008 chr10:133785129 A/C cg08754478 chr10:133766260 PPP2R2D -0.66 -9.47 -0.46 5.77e-19 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; CRC cis rs7107174 1.000 rs2511185 chr11:77982496 C/A cg02023728 chr11:77925099 USP35 0.5 8.62 0.43 2.89e-16 Testicular germ cell tumor; CRC cis rs7618915 0.547 rs1561337 chr3:52659963 C/T cg08222913 chr3:52553049 STAB1 -0.32 -5.83 -0.31 1.36e-8 Bipolar disorder; CRC cis rs11190604 1.000 rs10883512 chr10:102308516 A/G cg07080220 chr10:102295463 HIF1AN 0.47 5.66 0.3 3.31e-8 Palmitoleic acid (16:1n-7) levels; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg00016498 chr17:40307048 RAB5C 0.44 6.11 0.32 2.83e-9 Response to antipsychotic treatment; CRC cis rs1784581 0.500 rs9355379 chr6:162421466 C/T cg17173639 chr6:162384350 PARK2 0.69 9.51 0.46 4.3e-19 Itch intensity from mosquito bite; CRC cis rs7534824 0.582 rs17448827 chr1:101421407 G/A cg16556008 chr1:101360663 SLC30A7;EXTL2 0.58 5.64 0.3 3.67e-8 Refractive astigmatism; CRC cis rs9372498 0.536 rs62422228 chr6:118957276 T/C cg24463073 chr6:118973353 C6orf204 0.48 6.21 0.32 1.61e-9 Diastolic blood pressure; CRC trans rs7618501 0.633 rs11925192 chr3:50038664 G/A cg21582582 chr3:182698605 DCUN1D1 0.42 6.09 0.32 3.22e-9 Intelligence (multi-trait analysis); CRC cis rs11997175 0.603 rs12234894 chr8:33699275 G/C ch.8.33884649F chr8:33765107 NA 0.46 6.68 0.35 1.01e-10 Body mass index; CRC cis rs8014204 0.804 rs35769520 chr14:75255115 G/A cg03030879 chr14:75389066 RPS6KL1 -0.49 -7.83 -0.4 6.72e-14 Caffeine consumption; CRC cis rs3617 0.625 rs11715347 chr3:52883070 C/T cg07507251 chr3:52567010 NT5DC2 -0.41 -6.35 -0.33 7.08e-10 Red blood cell count;Autism spectrum disorder or schizophrenia; CRC trans rs7395662 0.929 rs10838982 chr11:48640168 C/T cg21153622 chr11:89784906 NA -0.48 -7.58 -0.39 3.51e-13 HDL cholesterol; CRC cis rs35110281 0.776 rs62226866 chr21:45024186 T/C cg04455712 chr21:45112962 RRP1B 0.41 8.02 0.4 1.87e-14 Mean corpuscular volume; CRC trans rs7267979 0.932 rs6115200 chr20:25487377 G/T cg17903999 chr18:56338584 MALT1 -0.41 -6.82 -0.35 4.3e-11 Liver enzyme levels (alkaline phosphatase); CRC cis rs4494114 1.000 rs9439081 chr1:39343012 A/G cg25970120 chr1:39325951 RRAGC -0.43 -5.97 -0.31 6.15e-9 Blood protein levels; CRC cis rs10504229 1.000 rs73607875 chr8:58173522 T/C cg24829409 chr8:58192753 C8orf71 -0.68 -11.34 -0.53 2.27e-25 Developmental language disorder (linguistic errors); CRC cis rs3741151 0.773 rs61345051 chr11:73112305 T/C cg17517138 chr11:73019481 ARHGEF17 1.01 8.22 0.41 4.68e-15 GIP levels in response to oral glucose tolerance test (120 minutes); CRC cis rs654950 0.934 rs653369 chr1:42002376 A/T cg06885757 chr1:42089581 HIVEP3 -0.51 -7.99 -0.4 2.35e-14 Airway imaging phenotypes; CRC cis rs4780401 0.728 rs6498239 chr16:11780774 T/C cg01061890 chr16:11836724 TXNDC11 -0.47 -6.64 -0.34 1.29e-10 Rheumatoid arthritis; CRC cis rs9467711 0.591 rs9461219 chr6:25836927 C/G cg16898833 chr6:26189333 HIST1H4D -0.78 -6.62 -0.34 1.45e-10 Autism spectrum disorder or schizophrenia; CRC cis rs9534288 0.731 rs2404730 chr13:46617381 G/A cg15192986 chr13:46630673 CPB2 -0.67 -9.67 -0.47 1.26e-19 Blood protein levels; CRC cis rs10504073 0.647 rs62507247 chr8:50013554 T/G cg00325661 chr8:49890786 NA 0.52 9.4 0.46 9.66e-19 Blood metabolite ratios; CRC trans rs12517041 0.935 rs10061491 chr5:23296773 T/C ch.8.1293020R chr8:59333349 UBXN2B -0.55 -6.17 -0.32 2.05e-9 Calcium levels; CRC cis rs60871478 0.730 rs13222476 chr7:826630 T/C cg13798912 chr7:905769 UNC84A 0.51 5.88 0.31 1.01e-8 Cerebrospinal P-tau181p levels; CRC cis rs7811142 0.943 rs67483801 chr7:100031758 G/T cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.89 12.33 0.56 5.45e-29 Platelet count; CRC cis rs11168351 0.750 rs11168366 chr12:48421773 T/C cg21466736 chr12:48725269 NA 0.46 6.95 0.36 1.98e-11 Bipolar disorder and schizophrenia; CRC cis rs28386778 0.897 rs2727328 chr17:61923564 G/A cg11494091 chr17:61959527 GH2 0.6 10.33 0.49 7.77e-22 Prudent dietary pattern; CRC cis rs57221529 0.766 rs72703026 chr5:572383 G/A cg09021430 chr5:549028 NA -0.72 -8.03 -0.4 1.78e-14 Lung disease severity in cystic fibrosis; CRC cis rs12681288 0.862 rs935821 chr8:1022455 G/A cg04851639 chr8:1020857 NA -0.36 -7.37 -0.38 1.43e-12 Schizophrenia; CRC cis rs17711722 0.565 rs4275112 chr7:65198619 T/G cg02869306 chr7:64672164 INTS4L1 0.44 7.56 0.38 4.12e-13 Calcium levels; CRC cis rs1552244 0.882 rs55840655 chr3:10042690 C/T cg08888203 chr3:10149979 C3orf24 0.62 8.3 0.42 2.65e-15 Alzheimer's disease; CRC cis rs11105298 0.685 rs117578503 chr12:89836672 G/C cg08166232 chr12:89918718 WDR51B;GALNT4 -0.6 -7.67 -0.39 2.01e-13 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; CRC cis rs7208859 0.623 rs9916727 chr17:29107472 A/G cg01831904 chr17:28903510 LRRC37B2 -0.63 -6.45 -0.33 4.07e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs172166 0.694 rs1225716 chr6:28113746 A/C cg12273811 chr6:28175739 NA 0.61 8.81 0.44 7.35e-17 Cardiac Troponin-T levels; CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg23784313 chr12:15942613 EPS8 -0.51 -6.42 -0.33 4.7e-10 Diisocyanate-induced asthma; CRC cis rs3733346 0.520 rs62297086 chr4:909040 G/A cg20916646 chr4:852691 GAK 0.49 7.26 0.37 2.78e-12 Sjögren's syndrome; CRC cis rs2949837 0.581 rs1543270 chr7:46006323 C/T cg10677697 chr7:45961126 IGFBP3 0.36 6.15 0.32 2.23e-9 Sitting height ratio; CRC cis rs3741404 0.609 rs669913 chr11:63869879 A/G cg05016508 chr11:63871570 FLRT1;MACROD1 0.53 8.88 0.44 4.37e-17 Platelet count; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg09852601 chr17:72732955 RAB37 0.38 6.19 0.32 1.82e-9 Liver disease severity in Alagille syndrome; CRC trans rs10983614 1.000 rs7867776 chr9:120072627 A/G cg22078869 chr5:134241244 PCBD2 0.52 7.0 0.36 1.45e-11 Survival in pancreatic cancer; CRC cis rs4927850 0.958 rs1975582 chr3:195751439 G/T cg12923728 chr3:195709715 SDHAP1 -0.71 -10.97 -0.52 4.39e-24 Pancreatic cancer; CRC cis rs4132509 1.000 rs4132509 chr1:243943084 A/C cg21452805 chr1:244014465 NA -0.48 -6.67 -0.35 1.08e-10 RR interval (heart rate); CRC cis rs4713118 0.629 rs203890 chr6:28022248 T/C cg23161317 chr6:28129485 ZNF389 0.44 5.78 0.3 1.74e-8 Parkinson's disease; CRC cis rs6964587 0.933 rs13230837 chr7:91779017 A/G cg17063962 chr7:91808500 NA 0.8 12.97 0.58 2.4e-31 Breast cancer; CRC cis rs9463078 0.605 rs7763421 chr6:44877313 A/G cg25276700 chr6:44698697 NA 0.25 5.98 0.31 5.86e-9 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; CRC cis rs1451375 0.729 rs6593017 chr7:50644812 G/A cg14593290 chr7:50529359 DDC 0.51 7.11 0.37 7.09e-12 Malaria; CRC cis rs5997397 0.934 rs6005864 chr22:29157487 A/G cg15103426 chr22:29168792 CCDC117 -0.42 -6.41 -0.33 5.14e-10 Red cell distribution width; CRC cis rs6952808 1.000 rs4601204 chr7:1890925 C/T cg02951883 chr7:2050386 MAD1L1 -0.73 -11.48 -0.53 7.11e-26 Bipolar disorder and schizophrenia; CRC cis rs6502050 0.734 rs7217625 chr17:80157766 T/C cg02741985 chr17:80059408 CCDC57 0.42 6.93 0.36 2.24e-11 Life satisfaction; CRC cis rs7727544 0.507 rs9791170 chr5:131569627 A/G cg11843238 chr5:131593191 PDLIM4 0.48 9.09 0.45 9.59e-18 Blood metabolite levels; CRC trans rs7873102 0.702 rs7028020 chr9:38007747 C/T cg18219212 chr1:16162653 FLJ37453 -0.41 -6.04 -0.32 4.19e-9 Brain structure; CRC cis rs4285028 0.948 rs13083557 chr3:121687613 G/A cg20356878 chr3:121714668 ILDR1 -0.48 -6.95 -0.36 1.93e-11 Multiple sclerosis; CRC cis rs9443645 0.527 rs9343870 chr6:79789473 T/G cg09184832 chr6:79620586 NA -0.45 -7.67 -0.39 1.9e-13 Intelligence (multi-trait analysis); CRC cis rs360798 0.512 rs2215870 chr2:63132342 C/G cg17519650 chr2:63277830 OTX1 0.45 6.54 0.34 2.41e-10 Coronary artery disease; CRC cis rs13118159 0.836 rs2293630 chr4:1342521 G/A cg23123621 chr4:1343375 KIAA1530 0.4 7.2 0.37 4.16e-12 Longevity; CRC cis rs10504229 1.000 rs58371676 chr8:58189382 G/A cg24829409 chr8:58192753 C8orf71 -0.68 -11.34 -0.53 2.27e-25 Developmental language disorder (linguistic errors); CRC cis rs62244186 0.632 rs1402751 chr3:44594030 C/A cg11003573 chr3:44754125 ZNF502 -0.34 -5.82 -0.31 1.4e-8 Depressive symptoms; CRC cis rs7932354 0.617 rs7118170 chr11:46908721 C/G cg19486271 chr11:47235900 DDB2 -0.42 -6.41 -0.33 5.01e-10 Bone mineral density (hip);Bone mineral density; CRC cis rs9287719 0.967 rs6712406 chr2:10754420 A/G cg00105475 chr2:10696890 NA 0.45 7.17 0.37 4.85e-12 Prostate cancer; CRC cis rs1218582 0.682 rs12046459 chr1:154912017 A/C cg03351412 chr1:154909251 PMVK 0.53 8.27 0.41 3.34e-15 Prostate cancer; CRC trans rs12478296 0.792 rs3924263 chr2:243005167 A/C cg18288967 chr1:45987694 PRDX1 0.68 7.72 0.39 1.37e-13 Obesity-related traits; CRC cis rs1059312 0.808 rs4760533 chr12:129297651 A/G cg21616243 chr12:129299702 MGC16384;SLC15A4 0.73 12.85 0.58 6.39e-31 Systemic lupus erythematosus; CRC cis rs6860806 0.661 rs28472559 chr5:131581611 G/A cg11843238 chr5:131593191 PDLIM4 0.41 7.92 0.4 3.73e-14 Breast cancer; CRC cis rs9467603 0.925 rs6456701 chr6:25774130 C/T cg16898833 chr6:26189333 HIST1H4D -0.72 -6.07 -0.32 3.44e-9 Intelligence (multi-trait analysis); CRC cis rs524281 0.773 rs2236652 chr11:66002681 G/A cg14036092 chr11:66035641 RAB1B -0.56 -6.35 -0.33 7.22e-10 Electroencephalogram traits; CRC cis rs6570726 0.935 rs446242 chr6:145843866 A/G cg23711669 chr6:146136114 FBXO30 0.67 11.93 0.55 1.68e-27 Lobe attachment (rater-scored or self-reported); CRC cis rs7799006 0.527 rs3779009 chr7:2203692 G/C cg21782813 chr7:2030301 MAD1L1 0.41 6.68 0.35 1.02e-10 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs3126085 0.935 rs12027807 chr1:152253726 C/G cg09127314 chr1:152161683 NA 0.45 5.86 0.31 1.14e-8 Atopic dermatitis; CRC cis rs2949837 0.581 rs924140 chr7:45963114 C/T cg23193639 chr7:45961078 IGFBP3 0.4 6.73 0.35 7.39e-11 Sitting height ratio; CRC cis rs2839186 0.588 rs2839140 chr21:47616080 G/A cg12516959 chr21:47718080 NA 0.33 5.87 0.31 1.09e-8 Testicular germ cell tumor; CRC cis rs2180341 0.538 rs3756993 chr6:127651551 A/C cg27446573 chr6:127587934 RNF146 0.62 9.17 0.45 5.19e-18 Breast cancer; CRC cis rs9491140 0.539 rs11751246 chr6:124692967 C/T cg05308643 chr6:124982296 NKAIN2 0.52 6.93 0.36 2.28e-11 Neuroticism; CRC cis rs172166 0.637 rs1071893 chr6:28167635 G/C cg12273811 chr6:28175739 NA 0.66 10.07 0.49 5.57e-21 Cardiac Troponin-T levels; CRC cis rs12701220 0.894 rs13224488 chr7:1052353 C/A cg26240231 chr7:1148101 C7orf50 -0.42 -5.61 -0.3 4.18e-8 Bronchopulmonary dysplasia; CRC cis rs72634258 0.503 rs34177663 chr1:7833228 A/G cg26816564 chr1:7831052 VAMP3 0.89 9.92 0.48 1.88e-20 Inflammatory bowel disease; CRC cis rs12692738 0.526 rs355840 chr2:165622122 C/G cg03182029 chr2:165697222 COBLL1 0.51 5.98 0.31 5.74e-9 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);Waist-to-hip ratio adjusted for BMI in non-smokers;Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction);Waist-to-hip ratio adjusted for body mass index; CRC cis rs7762018 0.891 rs4716343 chr6:170143817 C/G cg19338460 chr6:170058176 WDR27 -0.71 -7.8 -0.4 8.04e-14 Thiazide-induced adverse metabolic effects in hypertensive patients; CRC cis rs950169 0.922 rs4586394 chr15:84822385 G/A cg17507749 chr15:85114479 UBE2QP1 -0.76 -10.66 -0.51 5.68e-23 Schizophrenia; CRC cis rs4665809 0.590 rs62128457 chr2:26467347 C/A cg04944784 chr2:26401820 FAM59B 0.83 10.74 0.51 2.96e-23 Gut microbiome composition (summer); CRC trans rs1814175 0.817 rs10839401 chr11:49876144 C/T cg21153622 chr11:89784906 NA -0.38 -6.09 -0.32 3.21e-9 Height; CRC cis rs6429082 0.608 rs4659836 chr1:235564412 G/A cg26050004 chr1:235667680 B3GALNT2 -0.46 -6.02 -0.32 4.64e-9 Adiposity; CRC cis rs6951245 1.000 rs74369356 chr7:1071711 T/C cg22907277 chr7:1156413 C7orf50 0.71 7.39 0.38 1.26e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg15688767 chr3:125093330 ZNF148 0.46 6.01 0.31 4.95e-9 Thyroid stimulating hormone; CRC cis rs7772486 0.754 rs4895682 chr6:146062861 G/A cg05347473 chr6:146136440 FBXO30 -0.38 -5.65 -0.3 3.41e-8 Lobe attachment (rater-scored or self-reported); CRC cis rs6500602 1.000 rs6500602 chr16:4497451 T/C cg08645402 chr16:4508243 NA 0.57 9.44 0.46 7.1e-19 Schizophrenia; CRC cis rs7312933 0.584 rs6582391 chr12:42634686 G/A cg19980929 chr12:42632907 YAF2 0.49 7.51 0.38 5.71e-13 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CRC trans rs10982213 0.830 rs2274163 chr9:117188714 C/T cg19276012 chr2:219861030 NA 0.4 5.97 0.31 6.23e-9 Interleukin-6 levels; CRC cis rs3785574 0.927 rs2727313 chr17:61961914 A/G cg06601766 chr17:61851465 DDX42;CCDC47 0.59 8.36 0.42 1.74e-15 Height; CRC cis rs10782582 0.593 rs12126155 chr1:76131555 C/G cg10523679 chr1:76189770 ACADM -0.41 -5.76 -0.3 1.96e-8 Daytime sleep phenotypes; CRC cis rs6973256 0.828 rs2016876 chr7:133395492 T/G cg10665199 chr7:133106180 EXOC4 -0.39 -5.81 -0.31 1.44e-8 Intelligence (multi-trait analysis); CRC cis rs2760061 0.819 rs3094913 chr1:228206980 T/C cg18477163 chr1:228402036 OBSCN 0.42 7.04 0.36 1.14e-11 Diastolic blood pressure; CRC cis rs9814567 1.000 rs10935120 chr3:134233092 C/T cg06109529 chr3:134205091 CEP63;ANAPC13 0.8 12.01 0.55 8.59e-28 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg17465063 chr10:111985564 MXI1 0.41 6.6 0.34 1.66e-10 Liver disease severity in Alagille syndrome; CRC cis rs4975709 0.569 rs4975743 chr5:1859941 G/T cg11168104 chr5:1857477 NA -0.4 -6.73 -0.35 7.43e-11 Cardiovascular disease risk factors; CRC cis rs2204008 0.754 rs11181643 chr12:38380553 G/A cg26384229 chr12:38710491 ALG10B 0.69 9.77 0.47 5.95e-20 Bladder cancer; CRC cis rs1881797 1.000 rs10158379 chr1:247686352 C/A cg11166453 chr1:247681781 NA 0.43 7.0 0.36 1.48e-11 Acute lymphoblastic leukemia (childhood); CRC cis rs11764590 0.724 rs55789728 chr7:2107649 A/G cg02951883 chr7:2050386 MAD1L1 0.41 5.61 0.3 4.38e-8 Neuroticism; CRC cis rs2303745 0.589 rs8103523 chr19:17398269 A/G cg15110403 chr19:17392923 ANKLE1 -0.35 -5.68 -0.3 2.97e-8 Systemic lupus erythematosus; CRC cis rs7618915 0.547 rs4687548 chr3:52666650 A/T cg18099408 chr3:52552593 STAB1 -0.44 -7.13 -0.37 6.36e-12 Bipolar disorder; CRC cis rs832540 0.931 rs33319 chr5:56206675 C/A cg24531977 chr5:56204891 C5orf35 -0.49 -7.6 -0.39 3.18e-13 Coronary artery disease; CRC cis rs10504229 0.683 rs16921819 chr8:58107936 G/T cg21724239 chr8:58056113 NA 0.52 6.99 0.36 1.58e-11 Developmental language disorder (linguistic errors); CRC cis rs2180341 0.855 rs9385422 chr6:127716457 C/T cg27446573 chr6:127587934 RNF146 0.69 9.64 0.47 1.54e-19 Breast cancer; CRC cis rs7493 0.950 rs12704794 chr7:95036133 A/T cg20119798 chr7:94954144 PON1 -0.48 -6.19 -0.32 1.83e-9 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs651907 0.557 rs11720745 chr3:101441690 G/A cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.59 7.94 0.4 3.21e-14 Colorectal cancer; CRC cis rs2153535 0.580 rs2327061 chr6:8447231 G/C cg07606381 chr6:8435919 SLC35B3 0.67 10.79 0.51 1.94e-23 Motion sickness; CRC cis rs1448094 0.534 rs974818 chr12:86144307 T/C cg19622623 chr12:86230825 RASSF9 0.4 6.15 0.32 2.24e-9 Major depressive disorder; CRC cis rs7666738 0.830 rs13119995 chr4:99026790 T/C cg17366294 chr4:99064904 C4orf37 0.44 7.39 0.38 1.24e-12 Colonoscopy-negative controls vs population controls; CRC cis rs6502050 0.835 rs34960918 chr17:80113925 A/G cg02741985 chr17:80059408 CCDC57 0.43 7.15 0.37 5.66e-12 Life satisfaction; CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg07254608 chr8:41997973 NA -0.57 -7.05 -0.36 1.07e-11 Diisocyanate-induced asthma; CRC cis rs3768617 0.510 rs7518957 chr1:183093028 A/T ch.1.3577855R chr1:183094577 LAMC1 -0.84 -14.97 -0.64 5.36e-39 Fuchs's corneal dystrophy; CRC cis rs7809950 0.678 rs12670688 chr7:106821016 A/G cg23024343 chr7:107201750 COG5 0.7 9.39 0.46 1.03e-18 Coronary artery disease; CRC cis rs3785574 0.962 rs4968660 chr17:61792221 G/A cg23090583 chr17:61904693 PSMC5;FTSJ3 0.64 9.28 0.46 2.35e-18 Height; CRC cis rs9322193 0.504 rs7771014 chr6:150205446 T/A cg07701084 chr6:150067640 NUP43 0.44 6.32 0.33 8.49e-10 Lung cancer; CRC cis rs9491140 0.539 rs11154226 chr6:124681785 G/A cg19267163 chr6:125004984 NKAIN2 0.46 5.97 0.31 6.31e-9 Neuroticism; CRC cis rs3736485 0.934 rs2414105 chr15:51868373 A/G cg08986416 chr15:51914746 DMXL2 -0.45 -6.64 -0.34 1.3e-10 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs519973 1.000 rs1380476 chr3:187633843 C/T cg10168494 chr3:187635183 NA 0.5 8.53 0.43 5.59e-16 Allergic disease (asthma, hay fever or eczema); CRC cis rs9322193 0.923 rs35830138 chr6:149989771 T/C cg13206674 chr6:150067644 NUP43 0.64 9.59 0.47 2.3e-19 Lung cancer; CRC cis rs1005277 0.579 rs1740732 chr10:38491385 C/T cg25517755 chr10:38738941 LOC399744 -0.41 -5.98 -0.31 5.67e-9 Extrinsic epigenetic age acceleration; CRC trans rs3749237 0.964 rs1799843 chr3:49849723 G/A cg21659725 chr3:3221576 CRBN 0.57 8.22 0.41 4.88e-15 Resting heart rate; CRC cis rs6952808 0.723 rs11766575 chr7:2005747 T/C cg00106254 chr7:1943704 MAD1L1 -0.5 -7.21 -0.37 3.78e-12 Bipolar disorder and schizophrenia; CRC trans rs7613875 0.600 rs2624848 chr3:50165101 T/C cg21659725 chr3:3221576 CRBN -0.47 -6.8 -0.35 4.96e-11 Body mass index; CRC cis rs10071761 0.513 rs56157819 chr5:40362387 A/G cg09067459 chr5:40385259 NA -0.53 -7.11 -0.37 7.18e-12 Selective IgA deficiency; CRC cis rs7772486 0.840 rs2474355 chr6:146312540 C/G cg23711669 chr6:146136114 FBXO30 0.69 11.61 0.54 2.45e-26 Lobe attachment (rater-scored or self-reported); CRC cis rs6684514 1.000 rs12139321 chr1:156230429 A/G cg16558208 chr1:156270281 VHLL 0.62 9.75 0.47 6.96e-20 Mean corpuscular hemoglobin concentration;Glycated hemoglobin levels; CRC cis rs12999616 0.550 rs35358137 chr2:98502201 T/C cg26665480 chr2:98280029 ACTR1B 0.5 5.68 0.3 2.99e-8 Colorectal cancer; CRC cis rs17384381 0.861 rs12736004 chr1:85901367 G/A cg16011679 chr1:85725395 C1orf52 0.66 6.75 0.35 6.57e-11 Lobe attachment (rater-scored or self-reported); CRC cis rs1223397 0.530 rs2458313 chr6:13309789 C/T cg07912922 chr6:13274314 PHACTR1 0.4 6.24 0.33 1.34e-9 Blood pressure; CRC cis rs7113874 0.569 rs11041985 chr11:8582684 A/G cg17679104 chr11:8615758 STK33 -0.35 -5.86 -0.31 1.14e-8 Body mass index in physically active individuals;Body mass index (joint analysis main effects and physical activity interaction); CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg13108601 chr6:41748242 FRS3;PRICKLE4 0.49 6.38 0.33 5.89e-10 Thyroid stimulating hormone; CRC cis rs9486719 1.000 rs9400016 chr6:96940883 G/T cg06623918 chr6:96969491 KIAA0776 -0.76 -9.06 -0.45 1.19e-17 Migraine;Coronary artery disease; CRC trans rs7615952 0.641 rs7640158 chr3:125808011 G/A cg07211511 chr3:129823064 LOC729375 -0.71 -9.4 -0.46 9.34e-19 Blood pressure (smoking interaction); CRC cis rs8044868 0.530 rs12446480 chr16:72056757 A/G cg06172871 chr16:72088244 HP 0.39 5.69 0.3 2.81e-8 Body mass index (change over time) in cancer or chronic obstructive pulmonary disease;Body mass index (change over time) in cancer; CRC cis rs6912958 0.703 rs6903219 chr6:88096498 G/A cg08069147 chr6:88032118 GJB7;C6orf162 0.72 11.46 0.53 8.48e-26 Monocyte percentage of white cells; CRC cis rs10751667 0.666 rs12295141 chr11:947065 G/A cg01483505 chr11:975446 AP2A2 0.44 7.24 0.37 3.16e-12 Alzheimer's disease (late onset); CRC cis rs17666538 0.585 rs336444 chr8:633123 C/G cg26554054 chr8:600488 NA -0.52 -6.02 -0.31 4.66e-9 IgG glycosylation; CRC trans rs13046373 0.905 rs4816372 chr21:32077414 A/T cg13320257 chr7:1093903 C7orf50 -0.36 -6.15 -0.32 2.27e-9 HDL cholesterol; CRC cis rs736408 0.521 rs13074853 chr3:52779801 T/C cg11645453 chr3:52864694 ITIH4 0.36 6.48 0.34 3.31e-10 Bipolar disorder; CRC cis rs6121246 0.567 rs6058197 chr20:30194899 A/G cg13852791 chr20:30311386 BCL2L1 0.6 8.21 0.41 5.04e-15 Mean corpuscular hemoglobin; CRC cis rs2836974 0.568 rs452377 chr21:40537183 T/C cg22974920 chr21:40686053 BRWD1 0.43 6.08 0.32 3.31e-9 Cognitive function; CRC cis rs7659604 0.539 rs7660548 chr4:122730821 G/C cg06713675 chr4:122721982 EXOSC9 -0.51 -8.24 -0.41 4.19e-15 Type 2 diabetes; CRC cis rs763014 0.593 rs28455838 chr16:681966 T/C cg08989290 chr16:615782 NHLRC4 0.44 8.29 0.42 2.93e-15 Height; CRC cis rs832540 0.629 rs10461616 chr5:56080347 T/C cg12311346 chr5:56204834 C5orf35 -0.51 -7.52 -0.38 5.29e-13 Coronary artery disease; CRC cis rs9814567 1.000 rs1814337 chr3:134200682 C/T cg06109529 chr3:134205091 CEP63;ANAPC13 -0.83 -12.6 -0.57 5.76e-30 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs6570726 0.935 rs374000 chr6:145855290 C/T cg23711669 chr6:146136114 FBXO30 0.7 12.42 0.57 2.56e-29 Lobe attachment (rater-scored or self-reported); CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg17368874 chr8:145743346 RECQL4;LRRC14 0.52 7.52 0.38 5.3e-13 Anxiety disorder; CRC cis rs9303280 0.559 rs4795408 chr17:38107627 G/A cg26162295 chr17:38119207 GSDMA -0.33 -5.81 -0.3 1.5e-8 Self-reported allergy; CRC cis rs910316 0.737 rs175510 chr14:75524839 G/A cg03030879 chr14:75389066 RPS6KL1 0.42 6.36 0.33 6.78e-10 Height; CRC cis rs7726839 0.526 rs11960159 chr5:568685 C/T cg16447950 chr5:562315 NA -0.83 -12.7 -0.57 2.34e-30 Obesity-related traits; CRC cis rs2290405 0.527 rs6829987 chr4:932974 C/G cg04824913 chr4:887549 GAK -0.74 -10.96 -0.52 4.85e-24 Systemic sclerosis; CRC cis rs11077998 0.967 rs4789790 chr17:80510789 G/A cg10255544 chr17:80519551 FOXK2 0.37 5.72 0.3 2.39e-8 Reticulocyte fraction of red cells; CRC cis rs4363385 0.510 rs7532166 chr1:153046851 C/G cg25856811 chr1:152973957 SPRR3 -0.21 -5.66 -0.3 3.22e-8 Inflammatory skin disease; CRC cis rs9486719 0.843 rs2472876 chr6:96845723 A/G cg06623918 chr6:96969491 KIAA0776 0.79 8.57 0.43 4.23e-16 Migraine;Coronary artery disease; CRC cis rs6545883 0.965 rs7591345 chr2:61729641 T/A cg15711740 chr2:61764176 XPO1 -0.52 -7.12 -0.37 6.89e-12 Tuberculosis; CRC cis rs3806843 0.735 rs801188 chr5:140066916 G/T cg19875535 chr5:140030758 IK -0.63 -10.35 -0.5 6.54e-22 Depressive symptoms (multi-trait analysis); CRC trans rs951252 0.504 rs11734405 chr4:146081096 C/T cg24838029 chr1:43833615 ELOVL1 0.43 5.96 0.31 6.4e-9 Hip circumference; CRC cis rs9649213 0.593 rs6967457 chr7:97912221 T/G cg21770322 chr7:97807741 LMTK2 0.56 9.36 0.46 1.26e-18 Prostate cancer (SNP x SNP interaction); CRC trans rs7395662 0.963 rs7483713 chr11:48629214 A/T cg21153622 chr11:89784906 NA -0.44 -7.08 -0.36 8.62e-12 HDL cholesterol; CRC cis rs72730918 0.590 rs8025974 chr15:51985275 A/G cg14296394 chr15:51910925 DMXL2 -0.43 -5.79 -0.3 1.63e-8 Intelligence (multi-trait analysis); CRC cis rs6061231 0.556 rs6121571 chr20:60977323 T/G cg22633769 chr20:60982531 CABLES2 0.47 7.05 0.36 1.06e-11 Colorectal cancer; CRC cis rs12477438 0.520 rs6712704 chr2:99719687 C/T cg14399236 chr2:99771627 LIPT1;TSGA10 0.82 14.36 0.62 1.21e-36 Chronic sinus infection; CRC cis rs8180040 0.627 rs58956475 chr3:47224615 G/C cg02527881 chr3:46936655 PTH1R 0.35 6.11 0.32 2.83e-9 Colorectal cancer; CRC cis rs6426558 0.537 rs694740 chr1:227293451 A/G cg10327440 chr1:227177885 CDC42BPA 0.46 6.86 0.35 3.43e-11 Neutrophil percentage of white cells; CRC cis rs6502050 0.799 rs6502066 chr17:80103737 T/C cg22110888 chr17:80059540 CCDC57 0.4 6.44 0.33 4.17e-10 Life satisfaction; CRC cis rs3806843 0.676 rs2569159 chr5:140030710 C/T cg19875535 chr5:140030758 IK -0.67 -11.57 -0.54 3.28e-26 Depressive symptoms (multi-trait analysis); CRC cis rs7527798 0.571 rs4844611 chr1:207827538 G/C cg09232269 chr1:207846808 CR1L -0.45 -7.31 -0.37 2.02e-12 Erythrocyte sedimentation rate; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg00414561 chr15:23034473 NIPA2 -0.44 -6.66 -0.34 1.15e-10 Myopia (pathological); CRC cis rs11650494 0.710 rs77653195 chr17:47468868 A/T cg08112188 chr17:47440006 ZNF652 0.81 6.52 0.34 2.72e-10 Prostate cancer; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg18585273 chr17:66197086 NA 0.47 6.7 0.35 9.01e-11 Response to antipsychotic treatment; CRC cis rs10450586 0.863 rs7105447 chr11:27306238 A/G cg10370305 chr11:27303972 NA 0.37 6.02 0.31 4.69e-9 Total body bone mineral density; CRC cis rs7607369 0.559 rs4674341 chr2:219659911 A/G cg02176678 chr2:219576539 TTLL4 -0.38 -6.03 -0.32 4.44e-9 Red blood cell count;Amyotrophic lateral sclerosis; CRC cis rs7089973 0.604 rs17663387 chr10:116588060 C/G cg03647239 chr10:116582469 FAM160B1 0.4 5.78 0.3 1.77e-8 Bipolar disorder or attention deficit hyperactivity disorder; CRC cis rs798554 0.757 rs2533878 chr7:2878707 A/G cg14863265 chr7:2801509 GNA12 0.42 5.7 0.3 2.63e-8 Height; CRC cis rs1006703 0.544 rs35299172 chr17:3834598 C/T cg06463185 chr17:3833770 ATP2A3 0.55 6.62 0.34 1.49e-10 Glucose homeostasis traits; CRC cis rs60871478 0.636 rs4721600 chr7:871728 C/T cg05535760 chr7:792225 HEATR2 -0.9 -9.95 -0.48 1.44e-20 Cerebrospinal P-tau181p levels; CRC cis rs7618501 0.633 rs3774733 chr3:50037123 C/G cg24110177 chr3:50126178 RBM5 -0.47 -7.02 -0.36 1.26e-11 Intelligence (multi-trait analysis); CRC cis rs67311347 1.000 rs17078511 chr3:40396254 A/G cg09455208 chr3:40491958 NA 0.43 8.77 0.44 9.64e-17 Renal cell carcinoma; CRC cis rs7727544 0.904 rs7736102 chr5:131604257 G/A cg11843238 chr5:131593191 PDLIM4 0.34 6.57 0.34 1.94e-10 Blood metabolite levels; CRC cis rs67311347 1.000 rs7625736 chr3:40441345 C/G cg24209194 chr3:40518798 ZNF619 -0.43 -6.68 -0.35 1.05e-10 Renal cell carcinoma; CRC cis rs4604732 0.631 rs75600450 chr1:247625492 C/T cg02104434 chr1:247694406 LOC148824;OR2C3 0.6 8.83 0.44 6.22e-17 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CRC cis rs780096 0.526 rs3845686 chr2:27655447 T/G cg02592271 chr2:27665507 KRTCAP3 -0.28 -6.14 -0.32 2.39e-9 Total body bone mineral density; CRC cis rs4665809 0.590 rs1122972 chr2:26418788 A/C cg22920501 chr2:26401640 FAM59B -0.82 -11.68 -0.54 1.37e-26 Gut microbiome composition (summer); CRC cis rs427941 0.632 rs201497 chr7:101755928 A/C cg06246474 chr7:101738831 CUX1 0.44 6.73 0.35 7.61e-11 Plasma omega-3 polyunsaturated fatty acid level (eicosapentaenoic acid); CRC trans rs12906542 0.507 rs4395040 chr15:78282533 G/A cg16460994 chr15:82623834 NA 0.42 6.27 0.33 1.15e-9 Breast cancer; CRC cis rs4713118 0.513 rs1225591 chr6:28148752 G/A cg03623178 chr6:28175578 NA 0.81 11.99 0.55 1.02e-27 Parkinson's disease; CRC cis rs6424115 1.000 rs2179395 chr1:24148365 T/C cg15997130 chr1:24165203 NA 0.73 10.95 0.52 5.2e-24 Immature fraction of reticulocytes; CRC cis rs796364 1.000 rs10178177 chr2:200829993 G/A cg25936922 chr2:200820526 C2orf60;C2orf47 0.71 7.77 0.39 9.84e-14 Schizophrenia; CRC cis rs6502050 0.835 rs28481866 chr17:80105160 G/A cg19223190 chr17:80058835 NA 0.4 6.36 0.33 6.88e-10 Life satisfaction; CRC cis rs9796 0.870 rs3986311 chr15:41264339 C/G cg18705301 chr15:41695430 NDUFAF1 -0.39 -6.54 -0.34 2.32e-10 Menopause (age at onset); CRC trans rs7618501 0.521 rs3796386 chr3:49899795 G/A cg21665057 chr3:196295764 WDR53;FBXO45 0.54 7.97 0.4 2.7e-14 Intelligence (multi-trait analysis); CRC cis rs2070997 1.000 rs2070997 chr9:133748083 A/G cg01000188 chr9:133769184 QRFP 0.61 6.79 0.35 5.15e-11 Response to amphetamines; CRC cis rs13108904 0.901 rs2293634 chr4:1291711 T/G cg05025164 chr4:1340916 KIAA1530 0.38 5.62 0.3 4.17e-8 Obesity-related traits; CRC cis rs6545883 0.783 rs12713442 chr2:61848078 G/A cg15711740 chr2:61764176 XPO1 -0.43 -5.73 -0.3 2.24e-8 Tuberculosis; CRC cis rs6062302 0.522 rs3761126 chr20:62252044 C/T cg09650180 chr20:62225654 GMEB2 -0.51 -6.69 -0.35 9.64e-11 Glioblastoma; CRC cis rs853679 0.517 rs6922063 chr6:28094366 G/A cg15845792 chr6:28175446 NA 0.99 13.41 0.59 5.26e-33 Depression; CRC cis rs2836974 0.565 rs2836939 chr21:40578546 C/T cg17971929 chr21:40555470 PSMG1 0.56 6.17 0.32 2.06e-9 Cognitive function; CRC cis rs2732480 0.500 rs11168464 chr12:48602115 C/T cg21466736 chr12:48725269 NA -0.53 -8.05 -0.41 1.52e-14 Hemoglobin concentration;Red blood cell count;Hematocrit; CRC cis rs9303401 0.614 rs28651036 chr17:57080471 G/A cg02118635 chr17:56770003 RAD51C;TEX14 0.7 9.06 0.45 1.21e-17 Cognitive test performance; CRC cis rs9811920 0.695 rs1287284 chr3:99516962 C/A cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G -0.44 -6.19 -0.32 1.84e-9 Axial length; CRC cis rs2549003 0.966 rs839 chr5:131819126 C/T cg21138405 chr5:131827807 IRF1 0.57 11.38 0.53 1.59e-25 Asthma (sex interaction); CRC cis rs2239547 0.618 rs2071041 chr3:52864693 T/G cg11645453 chr3:52864694 ITIH4 0.69 14.23 0.62 3.75e-36 Schizophrenia; CRC cis rs6582630 0.560 rs12315134 chr12:38419857 T/A cg13010199 chr12:38710504 ALG10B -0.4 -5.68 -0.3 3.02e-8 Drug-induced liver injury (flucloxacillin); CRC cis rs736408 0.522 rs11130310 chr3:52674667 C/T cg08222913 chr3:52553049 STAB1 -0.33 -6.16 -0.32 2.11e-9 Bipolar disorder; CRC cis rs651907 0.557 rs13066768 chr3:101486920 A/T cg11279151 chr3:101281821 RG9MTD1 0.54 7.52 0.38 5.38e-13 Colorectal cancer; CRC cis rs2811415 0.597 rs13070488 chr3:127784118 T/C cg13719885 chr3:127795394 NA -0.39 -5.95 -0.31 6.69e-9 Lung function (FEV1/FVC); CRC cis rs28386778 0.897 rs2665823 chr17:61885917 G/A cg22520471 chr17:61851767 DDX42;CCDC47 0.75 11.74 0.54 7.89e-27 Prudent dietary pattern; CRC cis rs6951245 0.554 rs4724294 chr7:1139695 G/A cg24642844 chr7:1081250 C7orf50 -0.48 -6.32 -0.33 8.53e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs6500602 0.627 rs4786494 chr16:4506232 G/A cg06139259 chr16:4526053 HMOX2;NMRAL1 0.46 6.03 0.32 4.39e-9 Schizophrenia; CRC cis rs6570726 0.935 rs379164 chr6:145829093 A/T cg05347473 chr6:146136440 FBXO30 0.37 6.0 0.31 5.27e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs3820068 0.603 rs998032 chr1:15989918 T/C cg24675056 chr1:15929824 NA 0.54 7.31 0.37 2.07e-12 Systolic blood pressure; CRC cis rs7224685 0.520 rs12453690 chr17:4037678 T/C cg21851534 chr17:3907994 ZZEF1 -0.35 -5.73 -0.3 2.31e-8 Type 2 diabetes; CRC trans rs629535 0.814 rs651985 chr8:70054966 G/A cg21567404 chr3:27674614 NA 0.97 16.35 0.67 2.16e-44 Dupuytren's disease; CRC cis rs6500602 0.584 rs11646063 chr16:4439209 A/G cg08645402 chr16:4508243 NA -0.4 -6.26 -0.33 1.19e-9 Schizophrenia; CRC cis rs853679 0.517 rs4713144 chr6:28106790 C/G cg21251018 chr6:28226885 NKAPL 0.48 6.33 0.33 7.86e-10 Depression; CRC cis rs9814567 1.000 rs2370578 chr3:134199612 G/A cg06541857 chr3:134203789 ANAPC13;CEP63 -0.39 -5.74 -0.3 2.1e-8 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs62064224 0.560 rs12162135 chr17:30805795 A/C cg25809561 chr17:30822961 MYO1D 0.72 14.36 0.62 1.21e-36 Schizophrenia; CRC trans rs8005745 0.505 rs710047 chr14:62118819 C/G cg08551088 chr10:121631655 C10orf119 -0.47 -6.35 -0.33 7.18e-10 Select biomarker traits; CRC trans rs453301 0.624 rs330049 chr8:9087299 C/T cg06636001 chr8:8085503 FLJ10661 0.61 9.48 0.46 5.15e-19 Joint mobility (Beighton score); CRC cis rs877282 0.629 rs78997110 chr10:764388 A/G cg17470449 chr10:769945 NA 0.64 7.89 0.4 4.65e-14 Uric acid levels; CRC cis rs12477438 1.000 rs12466388 chr2:99916538 T/G cg14399236 chr2:99771627 LIPT1;TSGA10 -0.72 -9.02 -0.45 1.64e-17 Chronic sinus infection; CRC cis rs2404602 1.000 rs2056544 chr15:76826003 G/A cg22467129 chr15:76604101 ETFA -0.4 -6.82 -0.35 4.34e-11 Blood metabolite levels; CRC cis rs3741798 1.000 rs61922028 chr12:12487096 A/C cg08615371 chr12:12503544 MANSC1 1.09 10.13 0.49 3.48e-21 Cerebrospinal fluid biomarker levels; CRC cis rs7829975 0.871 rs777709 chr8:8583872 T/C cg08975724 chr8:8085496 FLJ10661 -0.45 -7.06 -0.36 9.8e-12 Mood instability; CRC cis rs7647973 0.961 rs62259943 chr3:49425167 A/G cg07690219 chr3:49449608 TCTA;RHOA 0.51 5.63 0.3 3.85e-8 Menarche (age at onset); CRC cis rs9733 0.680 rs3738484 chr1:150552330 G/T cg13175981 chr1:150552382 MCL1 0.39 5.63 0.3 3.78e-8 Tonsillectomy; CRC cis rs909674 0.818 rs5757681 chr22:39845547 A/G cg11247378 chr22:39784982 NA -0.39 -7.2 -0.37 4.06e-12 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; CRC cis rs763014 0.966 rs4984903 chr16:680695 A/G cg00908189 chr16:619842 PIGQ 0.66 10.67 0.51 5.09e-23 Height; CRC trans rs1814175 0.817 rs28502006 chr11:50049930 T/C cg15704280 chr7:45808275 SEPT13 -0.97 -19.11 -0.73 2.72e-55 Height; CRC cis rs17767392 0.881 rs17767680 chr14:71997594 G/A cg13720639 chr14:72061746 SIPA1L1 -0.57 -7.29 -0.37 2.34e-12 Mitral valve prolapse; CRC cis rs12477438 0.520 rs11123765 chr2:99768064 T/C cg26064155 chr2:99771622 LIPT1;TSGA10 0.9 16.75 0.68 5.43e-46 Chronic sinus infection; CRC cis rs9486715 0.830 rs4425602 chr6:96893906 G/A cg18709589 chr6:96969512 KIAA0776 0.48 7.23 0.37 3.37e-12 Headache; CRC cis rs7769051 0.803 rs34334052 chr6:133231829 C/T cg22852734 chr6:133119734 C6orf192 0.9 10.14 0.49 3.28e-21 Type 2 diabetes nephropathy; CRC cis rs2243480 1.000 rs160644 chr7:65558186 C/T cg12463550 chr7:65579703 CRCP 0.66 6.35 0.33 7.06e-10 Diabetic kidney disease; CRC cis rs10504229 0.683 rs11774645 chr8:58132921 G/C cg02290350 chr8:58132656 NA -0.59 -7.14 -0.37 6.05e-12 Developmental language disorder (linguistic errors); CRC cis rs2739330 0.828 rs4820572 chr22:24250355 T/C cg23131131 chr22:24373011 LOC391322 -0.69 -10.5 -0.5 1.91e-22 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs6963495 0.745 rs73190169 chr7:105160500 A/G cg02135003 chr7:105160482 PUS7 -0.9 -12.2 -0.56 1.71e-28 Bipolar disorder (body mass index interaction); CRC cis rs28386778 0.897 rs1982400 chr17:61793818 T/C cg11494091 chr17:61959527 GH2 0.59 10.04 0.48 7.34e-21 Prudent dietary pattern; CRC cis rs11650494 0.908 rs11656535 chr17:47425588 C/T cg08112188 chr17:47440006 ZNF652 1.19 11.24 0.53 4.98e-25 Prostate cancer; CRC cis rs875971 0.660 rs10215132 chr7:66054406 C/A cg00343986 chr7:65444356 GUSB -0.5 -7.52 -0.38 5.22e-13 Aortic root size; CRC cis rs3617 0.625 rs2336558 chr3:52886240 C/T cg18099408 chr3:52552593 STAB1 0.34 5.89 0.31 9.48e-9 Red blood cell count;Autism spectrum disorder or schizophrenia; CRC cis rs6089584 0.821 rs2273990 chr20:60579149 G/T cg18761221 chr20:60518478 NA 0.41 7.17 0.37 5.07e-12 Body mass index; CRC cis rs1364705 1.000 rs6986732 chr8:120225428 A/C cg27215916 chr8:120218354 NA -0.39 -5.64 -0.3 3.73e-8 Hippocampal atrophy; CRC cis rs9341808 0.718 rs10080237 chr6:80854470 T/C cg08355045 chr6:80787529 NA 0.42 6.84 0.35 3.92e-11 Sitting height ratio; CRC cis rs9443189 0.570 rs276684 chr6:76427065 A/G cg01950844 chr6:76311363 SENP6 -0.72 -9.14 -0.45 6.78e-18 Prostate cancer; CRC trans rs1814175 0.527 rs7110797 chr11:49644096 T/C cg03929089 chr4:120376271 NA -0.73 -9.78 -0.47 5.5e-20 Height; CRC cis rs6456156 0.586 rs12528323 chr6:167461645 A/G cg07741184 chr6:167504864 NA 0.39 6.9 0.36 2.63e-11 Primary biliary cholangitis; CRC trans rs2797160 0.904 rs1418637 chr6:125992553 A/G cg05039488 chr6:79577232 IRAK1BP1 -0.58 -8.7 -0.43 1.63e-16 Endometrial cancer; CRC trans rs6716963 0.672 rs7582395 chr2:194458906 G/T cg00362665 chr19:19370064 HAPLN4 -0.36 -5.97 -0.31 6.06e-9 Schizophrenia; CRC cis rs12479064 0.724 rs28369945 chr2:100080928 C/G cg26064155 chr2:99771622 LIPT1;TSGA10 -0.62 -7.26 -0.37 2.74e-12 Chronic sinus infection; CRC cis rs4665809 0.590 rs62128455 chr2:26466530 G/A cg26119090 chr2:26468346 HADHA;HADHB 1.06 15.5 0.65 4.69e-41 Gut microbiome composition (summer); CRC cis rs7264396 0.563 rs2425131 chr20:34337074 T/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.47 -6.43 -0.33 4.46e-10 Total cholesterol levels; CRC trans rs561341 1.000 rs8073186 chr17:30244956 T/C cg27661571 chr11:113659931 NA -0.54 -6.76 -0.35 6.24e-11 Hip circumference adjusted for BMI; CRC cis rs736408 0.608 rs6445534 chr3:52743384 G/A cg18099408 chr3:52552593 STAB1 -0.45 -7.61 -0.39 2.93e-13 Bipolar disorder; CRC cis rs7726839 0.526 rs11960158 chr5:568665 C/T cg14541582 chr5:601475 NA -0.28 -5.87 -0.31 1.08e-8 Obesity-related traits; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg08831002 chr7:20826153 SP8 -0.4 -6.15 -0.32 2.27e-9 Myopia (pathological); CRC cis rs1799949 1.000 rs9646417 chr17:41424253 G/A cg05368731 chr17:41323189 NBR1 0.64 9.32 0.46 1.76e-18 Menopause (age at onset); CRC trans rs629535 0.783 rs538832 chr8:70033817 A/G cg21567404 chr3:27674614 NA 0.95 16.08 0.66 2.35e-43 Dupuytren's disease; CRC cis rs992157 1.000 rs2168704 chr2:219142492 G/A cg04731861 chr2:219085781 ARPC2 -0.27 -5.78 -0.3 1.76e-8 Colorectal cancer; CRC cis rs7772486 0.754 rs6906258 chr6:146089356 A/G cg13319975 chr6:146136371 FBXO30 0.45 6.61 0.34 1.53e-10 Lobe attachment (rater-scored or self-reported); CRC cis rs8062405 1.000 rs55719896 chr16:28846866 G/A cg08761264 chr16:28874980 SH2B1 -0.42 -5.64 -0.3 3.73e-8 Cognitive ability (multi-trait analysis);Cognitive ability; CRC cis rs651907 0.557 rs3094297 chr3:101399260 A/G cg11279151 chr3:101281821 RG9MTD1 -0.5 -6.89 -0.36 2.77e-11 Colorectal cancer; CRC cis rs2576037 0.583 rs4890698 chr18:44489725 A/G cg19077165 chr18:44547161 KATNAL2 -0.68 -11.73 -0.54 8.51e-27 Personality dimensions; CRC cis rs6460942 0.915 rs62448600 chr7:12454944 T/G cg06484146 chr7:12443880 VWDE -0.78 -8.1 -0.41 1.11e-14 Coronary artery disease; CRC cis rs4076764 0.914 rs7536270 chr1:163377379 T/C cg06092702 chr1:163392909 NA -0.54 -8.47 -0.42 8.57e-16 Motion sickness; CRC trans rs7726839 0.540 rs4957080 chr5:644552 A/C cg11887960 chr12:57824829 NA -0.6 -6.68 -0.35 1.03e-10 Obesity-related traits; CRC trans rs1728785 0.901 rs7194664 chr16:68643313 T/C cg04657470 chr2:198365150 HSPE1;HSPD1 0.6 7.31 0.37 2.05e-12 Ulcerative colitis; CRC cis rs12545109 0.765 rs2055985 chr8:57410821 T/A cg09654669 chr8:57350985 NA -0.47 -7.57 -0.39 3.78e-13 Obesity-related traits; CRC cis rs7772486 0.654 rs9376958 chr6:146023040 C/T cg23711669 chr6:146136114 FBXO30 -0.64 -10.5 -0.5 1.9e-22 Lobe attachment (rater-scored or self-reported); CRC cis rs2839186 0.814 rs2839167 chr21:47661587 A/G cg11766577 chr21:47581405 C21orf56 -0.49 -7.99 -0.4 2.29e-14 Testicular germ cell tumor; CRC cis rs5769765 0.862 rs9616385 chr22:50313124 C/T cg04121214 chr22:50244548 NA 0.42 5.89 0.31 9.4e-9 Schizophrenia; CRC cis rs754466 0.606 rs7084705 chr10:79596675 A/G cg17075019 chr10:79541650 NA -0.96 -17.9 -0.7 1.7e-50 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs12410462 0.681 rs58496521 chr1:227582375 T/C cg23173402 chr1:227635558 NA 0.63 6.33 0.33 8.13e-10 Major depressive disorder; CRC cis rs2732480 0.500 rs7315820 chr12:48598938 C/T cg21466736 chr12:48725269 NA -0.52 -7.88 -0.4 4.88e-14 Hemoglobin concentration;Red blood cell count;Hematocrit; CRC trans rs1656966 1.000 rs1656966 chr3:186466252 C/T cg22357700 chr19:11805638 NA 0.4 6.04 0.32 4.28e-9 Myopia (pathological); CRC cis rs875971 0.660 rs801193 chr7:66030612 A/C cg25985355 chr7:65971099 NA 0.32 5.7 0.3 2.72e-8 Aortic root size; CRC cis rs11190604 0.673 rs10883498 chr10:102228709 T/A cg07080220 chr10:102295463 HIF1AN 0.47 5.83 0.31 1.31e-8 Palmitoleic acid (16:1n-7) levels; CRC cis rs17539620 0.808 rs57833052 chr6:154877112 C/T cg20019720 chr6:154832845 CNKSR3 0.41 6.53 0.34 2.53e-10 Lipoprotein (a) levels; CRC cis rs9322193 0.962 rs13215691 chr6:150113802 T/C cg05861140 chr6:150128134 PCMT1 -0.41 -6.66 -0.34 1.16e-10 Lung cancer; CRC cis rs10540 1.000 rs12418639 chr11:473300 A/C cg03934478 chr11:495069 RNH1 -0.62 -6.77 -0.35 6e-11 Body mass index; CRC cis rs4713118 0.513 rs149878 chr6:27878738 T/G cg20933634 chr6:27740509 NA 0.45 6.44 0.33 4.32e-10 Parkinson's disease; CRC cis rs6502050 0.835 rs62078306 chr17:80085341 A/G cg02741985 chr17:80059408 CCDC57 -0.44 -7.15 -0.37 5.61e-12 Life satisfaction; CRC cis rs4926298 1.000 rs8104231 chr19:13159569 A/T cg04657146 chr19:12876947 HOOK2 -0.43 -5.74 -0.3 2.12e-8 Bipolar disorder; CRC cis rs3096299 0.606 rs2965946 chr16:89516612 T/C cg05320533 chr16:89541815 ANKRD11 -0.41 -5.78 -0.3 1.78e-8 Multiple myeloma (IgH translocation); CRC cis rs9303280 0.901 rs869402 chr17:38068043 C/T cg00129232 chr17:37814104 STARD3 -0.45 -7.14 -0.37 5.98e-12 Self-reported allergy; CRC cis rs7618915 0.547 rs2286800 chr3:52778051 C/T cg05573699 chr3:52720067 GNL3;PBRM1 -0.44 -6.15 -0.32 2.23e-9 Bipolar disorder; CRC cis rs172166 0.694 rs1770131 chr6:28086413 C/T cg17949981 chr6:28129498 ZNF389 0.41 5.62 0.3 4.15e-8 Cardiac Troponin-T levels; CRC cis rs4888262 0.526 rs4887772 chr16:74537591 C/T cg01733217 chr16:74700730 RFWD3 0.76 11.36 0.53 1.95e-25 Testicular germ cell tumor; CRC cis rs9549328 0.700 rs4907568 chr13:113617574 A/T cg20742385 chr13:113633654 MCF2L -0.56 -9.76 -0.47 6.42e-20 Systolic blood pressure; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg23503864 chr12:64616369 C12orf66 0.44 6.5 0.34 2.99e-10 Intelligence (multi-trait analysis); CRC cis rs9487051 0.676 rs1608042 chr6:109595631 G/A cg12927641 chr6:109611667 NA -0.36 -6.44 -0.33 4.15e-10 Reticulocyte fraction of red cells; CRC cis rs6831352 0.734 rs2851259 chr4:100033986 C/T cg13256891 chr4:100009986 ADH5 0.56 7.89 0.4 4.44e-14 Alcohol dependence; CRC trans rs10504229 1.000 rs72650885 chr8:58175131 G/A cg04077850 chr5:125800366 GRAMD3 0.37 6.27 0.33 1.15e-9 Developmental language disorder (linguistic errors); CRC cis rs1707322 0.686 rs1084086 chr1:46041100 A/C cg06784218 chr1:46089804 CCDC17 -0.66 -12.26 -0.56 9.84e-29 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs919433 0.927 rs3843857 chr2:198195965 T/C cg10820045 chr2:198174542 NA -0.52 -8.87 -0.44 4.87e-17 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC cis rs736801 0.780 rs2188962 chr5:131770805 C/T cg02033258 chr5:131593261 PDLIM4 0.32 5.65 0.3 3.48e-8 Breast cancer;Mosquito bite size; CRC cis rs7703744 0.634 rs17145248 chr5:118685011 C/T cg17471836 chr5:118691007 TNFAIP8 0.41 5.62 0.3 4.03e-8 Lobe attachment (rater-scored or self-reported); CRC cis rs7538876 0.903 rs1324368 chr1:17752000 A/G cg07965774 chr1:17746286 RCC2 0.33 6.15 0.32 2.26e-9 Basal cell carcinoma; CRC cis rs2439831 0.850 rs10438303 chr15:44016417 T/C cg02155558 chr15:43621948 ADAL;LCMT2 0.71 7.68 0.39 1.9e-13 Lung cancer in ever smokers; CRC cis rs754466 0.580 rs10762763 chr10:79560803 C/G cg17075019 chr10:79541650 NA -0.89 -16.52 -0.67 4.71e-45 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs17711722 0.585 rs6942660 chr7:65302406 C/T cg18876405 chr7:65276391 NA 0.64 11.85 0.55 3.23e-27 Calcium levels; CRC cis rs798554 0.757 rs1182188 chr7:2869985 T/C cg19346786 chr7:2764209 NA -0.38 -6.63 -0.34 1.35e-10 Height; CRC trans rs5756813 0.754 rs13057133 chr22:38179473 C/T cg19894588 chr14:64061835 NA -0.55 -7.53 -0.38 4.93e-13 Optic cup area;Vertical cup-disc ratio; CRC cis rs10504229 0.953 rs66815941 chr8:58187306 C/T cg02725872 chr8:58115012 NA -0.38 -6.43 -0.33 4.44e-10 Developmental language disorder (linguistic errors); CRC cis rs703970 0.560 rs2764817 chr10:80972653 C/G cg20744163 chr10:80999841 ZMIZ1 -0.36 -5.74 -0.3 2.17e-8 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs6977660 0.507 rs28402966 chr7:19774469 A/C cg07541023 chr7:19748670 TWISTNB 0.78 7.27 0.37 2.58e-12 Thyroid stimulating hormone; CRC cis rs5769707 0.521 rs6009805 chr22:50058715 T/C cg20744362 chr22:50050164 C22orf34 0.32 5.82 0.31 1.38e-8 Monocyte count;Monocyte percentage of white cells; CRC cis rs801193 0.935 rs2286683 chr7:66129843 G/A cg18876405 chr7:65276391 NA -0.61 -10.75 -0.51 2.66e-23 Aortic root size; CRC cis rs12142240 0.659 rs67547686 chr1:46832229 G/C cg00530320 chr1:46809349 NSUN4 0.59 8.11 0.41 1.02e-14 Menopause (age at onset); CRC cis rs2243480 1.000 rs4149468 chr7:65825690 T/C cg18252515 chr7:66147081 NA -1.23 -14.4 -0.62 8.2e-37 Diabetic kidney disease; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg13801712 chr1:39325720 RRAGC 0.45 6.35 0.33 6.98e-10 Response to antipsychotic treatment; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg16478012 chr16:87425779 FBXO31;MAP1LC3B 0.45 6.41 0.33 5.17e-10 Anxiety disorder; CRC trans rs9858542 1.000 rs34762726 chr3:49689210 G/A cg21582582 chr3:182698605 DCUN1D1 -0.57 -7.01 -0.36 1.37e-11 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs7647973 0.516 rs4955418 chr3:49200627 A/G cg06212747 chr3:49208901 KLHDC8B 0.38 5.68 0.3 2.91e-8 Menarche (age at onset); CRC trans rs57221529 0.766 rs12521988 chr5:556421 C/T cg11887960 chr12:57824829 NA 0.58 6.44 0.33 4.17e-10 Lung disease severity in cystic fibrosis; CRC cis rs1153858 0.895 rs12593402 chr15:45617392 G/A cg14582100 chr15:45693742 SPATA5L1 0.29 5.69 0.3 2.83e-8 Homoarginine levels; CRC cis rs769267 0.930 rs2301786 chr19:19413947 A/G cg01262667 chr19:19385393 TM6SF2 0.38 6.24 0.33 1.36e-9 Tonsillectomy; CRC cis rs4132509 1.000 rs6659180 chr1:243995348 C/T cg21452805 chr1:244014465 NA 0.49 6.67 0.35 1.07e-10 RR interval (heart rate); CRC trans rs11343 0.675 rs7359333 chr16:19262344 A/T cg15849403 chr10:115803542 ADRB1 -0.47 -6.08 -0.32 3.35e-9 Parkinson's disease; CRC cis rs9733 0.628 rs7540874 chr1:150702663 A/C cg18016565 chr1:150552671 MCL1 0.45 6.52 0.34 2.57e-10 Tonsillectomy; CRC cis rs11098499 0.865 rs10032158 chr4:120391632 C/T cg24375607 chr4:120327624 NA 0.5 7.72 0.39 1.39e-13 Corneal astigmatism; CRC cis rs9399137 0.507 rs6904897 chr6:135382980 T/G cg22676075 chr6:135203613 NA 0.57 8.3 0.42 2.73e-15 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg18201393 chr15:75135266 ULK3 0.4 6.53 0.34 2.44e-10 Liver disease severity in Alagille syndrome; CRC cis rs2933343 0.729 rs1680781 chr3:128612830 C/A cg25356066 chr3:128598488 ACAD9 0.39 5.66 0.3 3.22e-8 IgG glycosylation; CRC cis rs7618915 0.547 rs2286800 chr3:52778051 C/T cg11645453 chr3:52864694 ITIH4 0.36 6.31 0.33 8.84e-10 Bipolar disorder; CRC cis rs11098499 0.738 rs34965784 chr4:120361586 G/C cg24375607 chr4:120327624 NA 0.52 8.04 0.41 1.66e-14 Corneal astigmatism; CRC cis rs61160187 0.750 rs1807017 chr5:60127724 T/C cg16298547 chr5:60138761 ELOVL7 -0.28 -6.01 -0.31 4.82e-9 Educational attainment (years of education);Educational attainment (college completion); CRC cis rs6815814 0.808 rs7653908 chr4:38782221 G/C cg06935464 chr4:38784597 TLR10 0.58 6.27 0.33 1.11e-9 Breast cancer; CRC cis rs4481887 0.927 rs4307598 chr1:248474544 T/C cg13385794 chr1:248469461 NA 0.38 6.64 0.34 1.32e-10 Common traits (Other); CRC cis rs9549367 0.789 rs9549698 chr13:113877701 A/G cg18105134 chr13:113819100 PROZ -0.75 -11.28 -0.53 3.51e-25 Platelet distribution width; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg22814256 chr22:41777658 TEF 0.44 6.2 0.32 1.72e-9 Response to antipsychotic treatment; CRC cis rs12291225 0.679 rs4756786 chr11:14285900 C/A cg19336497 chr11:14380999 RRAS2 -0.51 -8.58 -0.43 3.92e-16 Sense of smell; CRC cis rs7772486 0.846 rs866473 chr6:146353414 A/C cg13319975 chr6:146136371 FBXO30 -0.37 -5.65 -0.3 3.54e-8 Lobe attachment (rater-scored or self-reported); CRC cis rs12681287 0.547 rs13249177 chr8:87513034 A/G cg27223183 chr8:87520930 FAM82B -0.53 -7.46 -0.38 7.68e-13 Caudate activity during reward; CRC cis rs9309473 0.607 rs4641966 chr2:73590806 G/A cg20560298 chr2:73613845 ALMS1 -0.48 -6.5 -0.34 3.02e-10 Metabolite levels; CRC cis rs2294693 0.945 rs9381023 chr6:40983281 C/T cg14769373 chr6:40998127 UNC5CL 0.48 6.31 0.33 9.09e-10 Gastric cancer;Non-cardia gastric cancer; CRC cis rs10905065 0.861 rs10752069 chr10:5752403 A/G cg25171089 chr10:5708825 ASB13 0.41 5.66 0.3 3.31e-8 Menopause (age at onset); CRC cis rs1799949 0.965 rs33961729 chr17:41287924 C/A cg23758822 chr17:41437982 NA 0.8 13.44 0.6 3.93e-33 Menopause (age at onset); CRC cis rs7932354 0.583 rs11039014 chr11:46895378 C/T cg19486271 chr11:47235900 DDB2 -0.4 -5.97 -0.31 6.16e-9 Bone mineral density (hip);Bone mineral density; CRC cis rs12893668 0.703 rs34186780 chr14:104027595 T/G cg08213375 chr14:104286397 PPP1R13B 0.4 6.2 0.32 1.65e-9 Reticulocyte count; CRC cis rs28386778 0.799 rs12450683 chr17:61984299 C/G cg23090583 chr17:61904693 PSMC5;FTSJ3 0.81 14.15 0.62 7.69e-36 Prudent dietary pattern; CRC cis rs6429082 0.818 rs291391 chr1:235649955 A/G cg26050004 chr1:235667680 B3GALNT2 0.58 7.96 0.4 2.87e-14 Adiposity; CRC cis rs6564851 0.506 rs62054666 chr16:81259721 C/G cg05274606 chr16:81253692 PKD1L2 -0.38 -6.28 -0.33 1.05e-9 Carotenoid and tocopherol levels; CRC cis rs13191362 1.000 rs73035012 chr6:162997279 G/A cg23758597 chr6:163146217 PARK2 -0.55 -6.12 -0.32 2.61e-9 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg01741932 chr1:33816074 PHC2 0.43 6.23 0.32 1.42e-9 Response to antipsychotic treatment; CRC cis rs10504229 0.683 rs66730544 chr8:58127280 A/T cg04204079 chr8:58130323 NA -0.45 -5.78 -0.3 1.71e-8 Developmental language disorder (linguistic errors); CRC cis rs11734570 0.581 rs4401459 chr4:38585268 G/T cg18361445 chr4:38666374 KLF3;FLJ13197 -0.56 -7.22 -0.37 3.52e-12 Inflammatory bowel disease;Crohn's disease; CRC cis rs67311347 1.000 rs4246666 chr3:40407670 C/T cg24209194 chr3:40518798 ZNF619 0.42 6.51 0.34 2.8e-10 Renal cell carcinoma; CRC cis rs4713118 0.516 rs4713142 chr6:28106347 T/G cg15786705 chr6:28176104 NA 0.77 9.75 0.47 6.92e-20 Parkinson's disease; CRC cis rs6933660 0.760 rs1825368 chr6:151775259 C/A cg10883421 chr6:151773342 RMND1;C6orf211 0.76 13.7 0.6 4.19e-34 Menarche (age at onset); CRC cis rs10751667 0.600 rs10751672 chr11:948712 T/C cg01483505 chr11:975446 AP2A2 0.42 6.83 0.35 4.1e-11 Alzheimer's disease (late onset); CRC cis rs13031619 0.660 rs34855424 chr2:3702780 C/A cg19825600 chr2:3704501 ALLC -0.53 -6.37 -0.33 6.52e-10 Response to inhaled corticosteroid treatment in asthma (change in FEV1); CRC cis rs17270561 0.609 rs4711098 chr6:25734339 C/T cg17691542 chr6:26056736 HIST1H1C 0.73 9.26 0.45 2.71e-18 Iron status biomarkers; CRC cis rs2976388 0.590 rs10087426 chr8:143814554 G/A cg12516270 chr8:143859308 LYNX1 -0.4 -6.6 -0.34 1.69e-10 Urinary tract infection frequency; CRC cis rs4234284 0.556 rs13072737 chr3:126948835 C/T cg27326032 chr3:127006922 NA -0.49 -7.16 -0.37 5.42e-12 Adverse response to chemotherapy in breast cancer (alopecia) (docetaxel); CRC cis rs11190604 0.767 rs10736150 chr10:102195341 G/A cg07080220 chr10:102295463 HIF1AN -0.48 -6.17 -0.32 2.06e-9 Palmitoleic acid (16:1n-7) levels; CRC trans rs587242 1.000 rs35729443 chr1:96897468 C/T cg10631902 chr5:14652156 NA 0.44 6.84 0.35 3.84e-11 Body mass index (joint analysis main effects and physical activity interaction);Body mass index in physically inactive individuals;Body mass index; CRC cis rs6570726 0.791 rs11759979 chr6:145918881 C/T cg13319975 chr6:146136371 FBXO30 -0.44 -6.4 -0.33 5.43e-10 Lobe attachment (rater-scored or self-reported); CRC cis rs3785574 0.962 rs8066463 chr17:61818390 A/G cg06601766 chr17:61851465 DDX42;CCDC47 0.58 8.33 0.42 2.19e-15 Height; CRC cis rs7493 1.000 rs1034809 chr7:95051652 G/A cg07404485 chr7:94953653 PON1 -0.47 -6.14 -0.32 2.43e-9 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs6860806 0.507 rs2631371 chr5:131703691 G/A cg22638593 chr5:131593259 PDLIM4 -0.4 -6.54 -0.34 2.38e-10 Breast cancer; CRC cis rs6952808 0.608 rs6461049 chr7:2017445 C/T cg14004847 chr7:1930337 MAD1L1 0.45 6.55 0.34 2.2e-10 Bipolar disorder and schizophrenia; CRC cis rs7481584 0.624 rs449466 chr11:3047603 C/T cg25174290 chr11:3078921 CARS -0.4 -5.68 -0.3 3e-8 Calcium levels; CRC cis rs6599388 0.803 rs11248057 chr4:906131 C/G cg23939001 chr4:940644 TMEM175 -0.46 -7.67 -0.39 2.02e-13 Parkinson's disease; CRC cis rs17155006 0.664 rs448342 chr7:107739727 A/G cg05962710 chr7:107745446 LAMB4 -0.42 -7.36 -0.38 1.45e-12 Pneumococcal bacteremia; CRC cis rs2739330 0.734 rs2000467 chr22:24241533 C/T cg11905131 chr22:24372483 LOC391322 0.67 10.09 0.49 4.92e-21 Liver enzyme levels (gamma-glutamyl transferase); CRC trans rs3743266 0.613 rs2414669 chr15:60708824 A/G cg21431200 chr5:65017886 SGTB;NLN 0.4 6.22 0.32 1.47e-9 Menarche (age at onset); CRC cis rs8180040 0.966 rs2062278 chr3:47416761 C/T cg02527881 chr3:46936655 PTH1R -0.36 -6.67 -0.35 1.07e-10 Colorectal cancer; CRC cis rs4665809 0.590 rs9309474 chr2:26448830 T/A cg08067268 chr2:26466485 HADHB;HADHA -0.65 -8.34 -0.42 2e-15 Gut microbiome composition (summer); CRC cis rs35110281 0.667 rs4819286 chr21:45120121 G/A cg21573476 chr21:45109991 RRP1B -0.38 -5.71 -0.3 2.55e-8 Mean corpuscular volume; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg21552947 chr19:893353 MED16 0.48 6.01 0.31 4.92e-9 Thyroid stimulating hormone; CRC cis rs4862307 0.754 rs6846208 chr4:184991703 C/T cg06737308 chr4:185021514 ENPP6 0.45 6.89 0.35 2.9e-11 Serum dimethylarginine levels (asymmetric/symetric ratio); CRC cis rs7811142 1.000 rs66632384 chr7:100018904 G/A cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.62 8.15 0.41 7.87e-15 Platelet count; CRC cis rs61897795 0.628 rs174579 chr11:61605613 C/T cg06781209 chr11:61594997 FADS2 -0.58 -7.36 -0.38 1.48e-12 Neutrophil count;Sum basophil neutrophil counts; CRC cis rs9549367 0.789 rs35569628 chr13:113872712 T/C cg18105134 chr13:113819100 PROZ -0.72 -10.81 -0.51 1.61e-23 Platelet distribution width; CRC cis rs13256369 0.951 rs10503394 chr8:8565775 A/G cg06671706 chr8:8559999 CLDN23 0.63 9.34 0.46 1.51e-18 Obesity-related traits; CRC trans rs4263408 0.934 rs9683743 chr4:39703194 A/C cg19182908 chr22:38204192 GCAT -0.42 -6.2 -0.32 1.74e-9 Plasma amyloid beta peptide concentrations (ABx-40); CRC cis rs7618915 0.547 rs34537256 chr3:52657472 A/G cg15147215 chr3:52552868 STAB1 -0.62 -10.25 -0.49 1.37e-21 Bipolar disorder; CRC cis rs736408 0.924 rs2535629 chr3:52833219 C/T cg10802521 chr3:52805072 NEK4 -0.41 -5.92 -0.31 8.01e-9 Bipolar disorder; CRC cis rs11031096 0.563 rs12289940 chr11:4224589 T/A cg18678763 chr11:4115507 RRM1 -0.39 -6.17 -0.32 2.01e-9 Mean corpuscular volume;Mean corpuscular hemoglobin; CRC cis rs1048238 0.506 rs1262788 chr1:16215608 G/C cg21385522 chr1:16154831 NA -0.61 -9.08 -0.45 1.05e-17 Systolic blood pressure; CRC cis rs35883536 0.588 rs10465764 chr1:101105030 A/G cg14515779 chr1:101123966 NA -0.35 -6.21 -0.32 1.63e-9 Monocyte count; CRC cis rs853679 0.550 rs6901017 chr6:28152583 T/C cg21251018 chr6:28226885 NKAPL 0.47 6.34 0.33 7.71e-10 Depression; CRC cis rs3996993 0.809 rs111906843 chr6:52690014 G/A cg20803780 chr6:52668592 GSTA1 0.36 6.34 0.33 7.41e-10 Hemoglobin concentration; CRC trans rs7615952 0.546 rs2976733 chr3:125414138 T/C cg16558177 chr4:4109446 NA -0.62 -8.88 -0.44 4.31e-17 Blood pressure (smoking interaction); CRC cis rs7178572 0.568 rs11072653 chr15:77693934 C/T cg22256960 chr15:77711686 NA -0.66 -9.63 -0.47 1.72e-19 Type 2 diabetes; CRC cis rs1005277 0.579 rs1985707 chr10:38434098 C/T cg25427524 chr10:38739819 LOC399744 -0.76 -13.4 -0.59 5.83e-33 Extrinsic epigenetic age acceleration; CRC cis rs10504073 0.626 rs6472220 chr8:50008477 C/A cg00325661 chr8:49890786 NA 0.43 7.67 0.39 1.98e-13 Blood metabolite ratios; CRC cis rs514406 0.621 rs928452 chr1:53195926 G/C cg24675658 chr1:53192096 ZYG11B 0.68 10.55 0.5 1.36e-22 Monocyte count; CRC cis rs597539 0.552 rs6591361 chr11:68719284 T/C cg04772025 chr11:68637568 NA 0.44 6.76 0.35 6.12e-11 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs4862750 0.872 rs9997374 chr4:187877549 T/A cg10295955 chr4:187884368 NA -1.03 -25.51 -0.81 6.14e-80 Lobe attachment (rater-scored or self-reported); CRC cis rs7945705 0.870 rs10840142 chr11:8906078 A/G cg00186954 chr11:8933980 ST5;C11orf17 0.47 7.24 0.37 3.14e-12 Hemoglobin concentration; CRC cis rs4742903 0.935 rs3818626 chr9:106856633 C/T cg14250997 chr9:106856677 SMC2 0.39 5.66 0.3 3.3e-8 High-grade serous ovarian cancer;Breast cancer; CRC cis rs6831352 0.918 rs17817958 chr4:100061245 A/C cg12011299 chr4:100065546 ADH4 0.5 9.05 0.45 1.24e-17 Alcohol dependence; CRC cis rs6860806 0.507 rs272891 chr5:131664394 G/T cg18758796 chr5:131593413 PDLIM4 0.39 6.31 0.33 9.03e-10 Breast cancer; CRC cis rs3815700 1.000 rs8109885 chr19:33095557 A/G cg02997394 chr19:33096574 ANKRD27 0.73 8.3 0.42 2.81e-15 Eosinophilic esophagitis; CRC cis rs4625783 0.583 rs11077974 chr17:80095193 A/G cg09264619 chr17:80180166 NA -0.34 -5.81 -0.3 1.5e-8 Blood metabolite levels; CRC cis rs4481887 0.597 rs4504921 chr1:248582011 T/C cg00666640 chr1:248458726 OR2T12 0.36 6.15 0.32 2.21e-9 Common traits (Other); CRC cis rs55788414 1.000 rs7499792 chr16:81184318 C/T cg06400318 chr16:81190750 PKD1L2 -0.59 -6.76 -0.35 6.2e-11 Left ventricular obstructive tract defect (maternal effect); CRC cis rs8177253 0.665 rs9831392 chr3:133451473 A/T cg16262614 chr3:133464971 TF 0.4 7.09 0.36 8.42e-12 Iron status biomarkers; CRC cis rs1552244 1.000 rs35741213 chr3:10087661 A/G cg16606324 chr3:10149918 C3orf24 0.72 9.82 0.48 3.92e-20 Alzheimer's disease; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg03043827 chr4:128981985 LARP1B 0.37 6.29 0.33 1.04e-9 Liver disease severity in Alagille syndrome; CRC cis rs1568889 0.838 rs7943538 chr11:28288955 A/G cg06544937 chr11:28130018 METT5D1;KIF18A 0.89 15.41 0.65 1.05e-40 Bipolar disorder; CRC cis rs9583531 0.550 rs7985098 chr13:111386416 G/A cg24331049 chr13:111365604 ING1 0.5 7.01 0.36 1.33e-11 Coronary artery disease; CRC cis rs7680126 0.596 rs35782983 chr4:10117728 G/A cg11266682 chr4:10021025 SLC2A9 -0.46 -6.77 -0.35 5.94e-11 Urate levels in lean individuals;Urate levels in overweight individuals;Urate levels in obese individuals; CRC cis rs1046896 0.553 rs56775875 chr17:80831291 G/T cg03160526 chr17:80928410 B3GNTL1 0.58 7.78 0.39 9.14e-14 Glycated hemoglobin levels; CRC cis rs2629540 0.793 rs10794180 chr10:126449306 T/A cg08799069 chr10:126477246 METTL10 -0.65 -8.91 -0.44 3.45e-17 Cocaine dependence; CRC cis rs478304 0.903 rs61895677 chr11:65549415 T/C cg27068330 chr11:65405492 SIPA1 0.46 6.85 0.35 3.59e-11 Acne (severe); CRC trans rs8005150 0.737 rs73312845 chr14:88462861 T/A cg25527770 chr19:1444892 NA -0.55 -6.04 -0.32 4.12e-9 Hepatitis B; CRC cis rs8016982 0.633 rs4363794 chr14:81674327 C/A cg01989461 chr14:81687754 GTF2A1 0.49 7.74 0.39 1.24e-13 Schizophrenia; CRC cis rs6918586 0.557 rs198827 chr6:26121002 C/T cg18357526 chr6:26021779 HIST1H4A -0.49 -7.3 -0.37 2.24e-12 Schizophrenia; CRC trans rs12495832 0.778 rs79933115 chr3:147922205 A/G cg10221266 chr7:153579447 NA 0.56 6.06 0.32 3.79e-9 Chin dimples; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg19683457 chr6:105307726 HACE1 0.47 7.71 0.39 1.54e-13 Liver disease severity in Alagille syndrome; CRC trans rs10983614 1.000 rs7867776 chr9:120072627 A/G cg19363699 chr19:11639867 ECSIT 0.44 6.17 0.32 2.05e-9 Survival in pancreatic cancer; CRC trans rs10242455 0.557 rs45529541 chr7:99048143 C/A cg09045935 chr12:6379348 NA 1.03 8.84 0.44 5.85e-17 Blood metabolite levels; CRC cis rs780096 0.506 rs780100 chr2:27652153 G/T cg21248554 chr2:27665150 KRTCAP3 -0.33 -7.76 -0.39 1.11e-13 Total body bone mineral density; CRC cis rs2721195 0.967 rs748195 chr8:145682514 T/C cg17328964 chr8:145687451 CYHR1 -0.75 -13.93 -0.61 5.65e-35 Age at first birth; CRC cis rs736408 0.609 rs2336545 chr3:52787603 C/T cg18404041 chr3:52824283 ITIH1 0.42 8.61 0.43 3.18e-16 Bipolar disorder; CRC cis rs9359856 0.529 rs1328017 chr6:90297603 T/C cg13799429 chr6:90582589 CASP8AP2 0.73 7.77 0.39 9.97e-14 Bipolar disorder; CRC cis rs926938 0.563 rs360642 chr1:115425429 C/G cg12756093 chr1:115239321 AMPD1 0.55 8.34 0.42 2.03e-15 Autism; CRC cis rs57994353 0.897 rs35526483 chr9:139364940 G/A cg13611204 chr9:139324423 INPP5E -0.4 -5.7 -0.3 2.65e-8 Eosinophil counts;Cutaneous squamous cell carcinoma; CRC cis rs7666738 0.830 rs28795113 chr4:98951331 A/G cg17366294 chr4:99064904 C4orf37 0.43 7.34 0.38 1.69e-12 Colonoscopy-negative controls vs population controls; CRC cis rs877282 0.945 rs10904556 chr10:789429 A/G cg17470449 chr10:769945 NA 0.67 8.71 0.43 1.5e-16 Uric acid levels; CRC cis rs9325144 0.555 rs12424003 chr12:38688140 C/T cg26384229 chr12:38710491 ALG10B -0.58 -8.55 -0.43 4.83e-16 Morning vs. evening chronotype; CRC cis rs7917772 0.582 rs12782153 chr10:104368294 A/G cg11453585 chr10:104263688 ACTR1A;SUFU -0.83 -14.83 -0.63 1.81e-38 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC cis rs12594515 1.000 rs7173144 chr15:45991196 A/G cg01629716 chr15:45996671 NA 0.4 8.3 0.42 2.67e-15 Waist circumference;Weight; CRC trans rs7267979 0.727 rs4815431 chr20:25532405 T/C cg17903999 chr18:56338584 MALT1 0.4 6.52 0.34 2.7e-10 Liver enzyme levels (alkaline phosphatase); CRC cis rs8072100 0.701 rs4794053 chr17:45769551 G/A cg08085267 chr17:45401833 C17orf57 -0.44 -6.47 -0.34 3.51e-10 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs7737355 0.947 rs12659474 chr5:130801304 T/C cg06307176 chr5:131281290 NA -0.43 -6.36 -0.33 6.6e-10 Life satisfaction; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg19127360 chr2:242089945 PPP1R7;PASK 0.45 6.53 0.34 2.43e-10 Anxiety disorder; CRC cis rs11155671 0.530 rs4869764 chr6:150211828 T/C cg13206674 chr6:150067644 NUP43 0.48 6.89 0.36 2.77e-11 Testicular germ cell tumor; CRC cis rs6982240 0.514 rs892362 chr8:142269214 A/G cg00672558 chr8:142262059 NA -0.36 -5.75 -0.3 2.09e-8 Tonsillectomy; CRC cis rs970548 0.909 rs55665473 chr10:46022005 G/A cg15590007 chr10:45870220 ALOX5 0.49 6.24 0.33 1.36e-9 Total cholesterol levels;Cholesterol, total;HDL cholesterol;HDL cholesterol levels; CRC cis rs230203 0.506 rs230194 chr20:55774345 A/G cg13236649 chr20:55835020 BMP7 0.42 6.22 0.32 1.53e-9 Monobrow; CRC cis rs7043114 0.525 rs7047089 chr9:95117980 C/T cg14631576 chr9:95140430 CENPP -0.31 -5.84 -0.31 1.22e-8 Height; CRC cis rs294883 0.826 rs400764 chr6:159698518 A/C cg14500486 chr6:159655392 FNDC1 -0.36 -5.82 -0.31 1.4e-8 Coronary artery disease; CRC cis rs2239547 0.603 rs2276825 chr3:52886605 T/C cg10802521 chr3:52805072 NEK4 -0.46 -6.15 -0.32 2.24e-9 Schizophrenia; CRC cis rs11098499 1.000 rs3749591 chr4:120214030 T/G cg24375607 chr4:120327624 NA 0.49 7.49 0.38 6.39e-13 Corneal astigmatism; CRC cis rs909002 0.830 rs10914460 chr1:32113216 T/C cg13919466 chr1:32135498 COL16A1 -0.32 -6.01 -0.31 4.89e-9 Intelligence (multi-trait analysis); CRC cis rs7772486 0.686 rs857883 chr6:145969214 G/T cg23711669 chr6:146136114 FBXO30 -0.73 -12.39 -0.56 3.43e-29 Lobe attachment (rater-scored or self-reported); CRC cis rs2777491 0.915 rs7178777 chr15:41634588 C/A cg18705301 chr15:41695430 NDUFAF1 -0.69 -11.43 -0.53 1.08e-25 Ulcerative colitis; CRC cis rs7089973 0.872 rs35628210 chr10:116630031 G/A cg03647239 chr10:116582469 FAM160B1 0.41 5.77 0.3 1.82e-8 Bipolar disorder or attention deficit hyperactivity disorder; CRC trans rs12599106 0.818 rs17723574 chr16:34602945 C/G cg18110333 chr6:292329 DUSP22 -0.56 -8.32 -0.42 2.3e-15 Menopause (age at onset); CRC cis rs875971 0.617 rs810400 chr7:66022889 G/C cg25985355 chr7:65971099 NA 0.32 5.67 0.3 3.12e-8 Aortic root size; CRC trans rs6703335 0.870 rs10803142 chr1:243598234 A/G cg23097961 chr19:49055412 SULT2B1 0.2 6.04 0.32 4.22e-9 Schizophrenia;Schizophrenia, schizoaffective disorder or bipolar disorder; CRC trans rs7726839 0.540 rs72705102 chr5:659437 T/C cg25482853 chr8:67687455 SGK3 1.12 13.05 0.58 1.19e-31 Obesity-related traits; CRC cis rs736408 0.609 rs2268025 chr3:52795224 A/T cg05573699 chr3:52720067 GNL3;PBRM1 -0.44 -6.13 -0.32 2.49e-9 Bipolar disorder; CRC trans rs17685 0.753 rs7788763 chr7:75651665 T/C cg19862616 chr7:65841803 NCRNA00174 -0.94 -16.54 -0.67 3.8e-45 Coffee consumption;Coffee consumption (cups per day); CRC cis rs57590327 0.555 rs3943556 chr3:81738892 G/C cg07356753 chr3:81810745 GBE1 -0.66 -8.84 -0.44 6.1e-17 Extraversion; CRC cis rs7666738 0.791 rs1559860 chr4:99024422 C/T cg05340658 chr4:99064831 C4orf37 0.61 9.42 0.46 8.23e-19 Colonoscopy-negative controls vs population controls; CRC cis rs5769707 0.967 rs5769698 chr22:49997706 A/G cg05373962 chr22:49881684 NA -0.37 -6.99 -0.36 1.54e-11 Monocyte count;Monocyte percentage of white cells; CRC cis rs897984 0.759 rs13708 chr16:31000809 G/A cg02466173 chr16:30829666 NA 0.63 9.56 0.47 2.81e-19 Dementia with Lewy bodies; CRC cis rs4862750 0.957 rs2375916 chr4:187903923 A/G cg03452623 chr4:187889614 NA -0.96 -22.5 -0.78 1.6e-68 Lobe attachment (rater-scored or self-reported); CRC cis rs7811142 1.000 rs67315960 chr7:100015124 A/G cg00814883 chr7:100076585 TSC22D4 -0.75 -9.48 -0.46 5.22e-19 Platelet count; CRC cis rs12681288 0.823 rs4735974 chr8:1000218 T/G cg04851639 chr8:1020857 NA -0.31 -6.64 -0.34 1.33e-10 Schizophrenia; CRC cis rs477692 0.837 rs543454 chr10:131420536 T/C cg05714579 chr10:131428358 MGMT 0.59 8.44 0.42 1.02e-15 Response to temozolomide; CRC trans rs57221529 0.766 rs28563961 chr5:554498 C/G cg25482853 chr8:67687455 SGK3 1.26 15.41 0.65 1.01e-40 Lung disease severity in cystic fibrosis; CRC cis rs6840360 0.571 rs4696271 chr4:152509118 G/A cg09659197 chr4:152720779 NA 0.32 5.75 0.3 2.09e-8 Intelligence (multi-trait analysis); CRC cis rs6714710 0.580 rs11690737 chr2:98461953 C/T cg26665480 chr2:98280029 ACTR1B 0.51 7.01 0.36 1.4e-11 Posterior cortical atrophy and Alzheimer's disease; CRC cis rs9818758 0.607 rs73082362 chr3:49113729 C/T cg01304814 chr3:48885189 PRKAR2A 0.86 6.24 0.33 1.32e-9 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; CRC cis rs12142240 0.730 rs56030283 chr1:46823093 C/G cg14993813 chr1:46806288 NSUN4 -0.49 -6.22 -0.32 1.55e-9 Menopause (age at onset); CRC cis rs977987 0.843 rs10431974 chr16:75435461 A/G cg03315344 chr16:75512273 CHST6 0.54 9.06 0.45 1.19e-17 Dupuytren's disease; CRC cis rs1448094 0.512 rs1349063 chr12:86264237 C/T cg02569458 chr12:86230093 RASSF9 0.42 7.07 0.36 9.32e-12 Major depressive disorder; CRC cis rs7202877 0.610 rs11149814 chr16:75332981 T/C cg03315344 chr16:75512273 CHST6 0.5 5.92 0.31 8.08e-9 Type 2 diabetes;Type 1 diabetes; CRC trans rs7267979 1.000 rs6050566 chr20:25351071 G/A cg17903999 chr18:56338584 MALT1 0.4 6.66 0.34 1.18e-10 Liver enzyme levels (alkaline phosphatase); CRC cis rs9611565 0.659 rs9607812 chr22:41941243 G/A cg06481639 chr22:41940642 POLR3H -0.51 -5.87 -0.31 1.08e-8 Vitiligo; CRC cis rs1448094 0.773 rs11117100 chr12:86310392 A/G cg18827107 chr12:86230957 RASSF9 -0.44 -7.21 -0.37 3.81e-12 Major depressive disorder; CRC cis rs9517320 0.967 rs7997785 chr13:99127985 T/A cg20487152 chr13:99095054 FARP1 0.36 5.93 0.31 7.65e-9 Longevity; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg13066542 chr9:79009738 RFK 0.43 6.23 0.32 1.44e-9 Intelligence (multi-trait analysis); CRC cis rs9611565 0.659 rs9611609 chr22:41945357 C/A cg06634786 chr22:41940651 POLR3H -0.66 -7.69 -0.39 1.7e-13 Vitiligo; CRC cis rs17376456 0.877 rs34184666 chr5:93444584 T/C cg09848695 chr5:92956644 FAM172A;MIR2277 0.63 5.83 0.31 1.29e-8 Diabetic retinopathy; CRC cis rs7216064 0.953 rs4791046 chr17:65851973 G/A cg12091567 chr17:66097778 LOC651250 -0.64 -8.05 -0.41 1.56e-14 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CRC cis rs2243480 1.000 rs462853 chr7:65558167 G/C cg25985355 chr7:65971099 NA -0.47 -5.65 -0.3 3.54e-8 Diabetic kidney disease; CRC cis rs10504229 0.511 rs75967910 chr8:58024231 C/G cg02725872 chr8:58115012 NA -0.52 -7.17 -0.37 5.06e-12 Developmental language disorder (linguistic errors); CRC cis rs932541 1.000 rs6034489 chr20:16456812 G/A cg17003395 chr20:16555519 KIF16B 0.41 5.63 0.3 3.82e-8 Intelligence; CRC cis rs2976388 0.609 rs2717550 chr8:143787808 T/A cg12516270 chr8:143859308 LYNX1 0.44 7.92 0.4 3.69e-14 Urinary tract infection frequency; CRC cis rs9381040 0.655 rs2268194 chr6:41024447 T/C cg04346459 chr6:41068666 NFYA;LOC221442 -0.41 -6.14 -0.32 2.43e-9 Alzheimer's disease (late onset); CRC cis rs4589502 0.512 rs7183242 chr15:67096658 A/G cg09911534 chr15:67153556 NA -0.45 -6.73 -0.35 7.64e-11 Lung cancer (smoking interaction); CRC cis rs912057 0.932 rs1294404 chr6:6735022 G/A cg06612196 chr6:6737390 NA 0.56 8.88 0.44 4.3e-17 Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction); CRC cis rs4713118 0.869 rs4713121 chr6:27722064 T/C cg15786705 chr6:28176104 NA 0.63 8.02 0.4 1.83e-14 Parkinson's disease; CRC cis rs6540556 0.859 rs12079960 chr1:209937168 A/C cg23920097 chr1:209922102 NA -0.51 -6.55 -0.34 2.17e-10 Red blood cell count; CRC cis rs12325245 0.536 rs34129245 chr16:58588191 A/G cg02549819 chr16:58548995 SETD6 1.16 7.58 0.39 3.52e-13 Schizophrenia; CRC cis rs6502050 0.835 rs11077981 chr17:80147243 C/T cg13198984 chr17:80129470 CCDC57 0.43 7.56 0.38 3.92e-13 Life satisfaction; CRC trans rs7267979 1.000 rs6037095 chr20:25335687 A/G cg17903999 chr18:56338584 MALT1 0.41 6.79 0.35 5.18e-11 Liver enzyme levels (alkaline phosphatase); CRC cis rs6586163 0.872 rs7082101 chr10:90741615 C/A cg03111039 chr10:90751583 FAS;ACTA2 -0.5 -7.08 -0.36 8.67e-12 Chronic lymphocytic leukemia; CRC trans rs1814175 0.546 rs1614397 chr11:49913384 G/C cg11707556 chr5:10655725 ANKRD33B -0.42 -7.98 -0.4 2.5e-14 Height; CRC cis rs6088580 0.634 rs6088471 chr20:32932643 C/A cg24642439 chr20:33292090 TP53INP2 -0.4 -6.68 -0.35 1.03e-10 Glomerular filtration rate (creatinine); CRC cis rs2243480 1.000 rs383402 chr7:65586653 A/C cg18252515 chr7:66147081 NA 1.1 12.56 0.57 8.06e-30 Diabetic kidney disease; CRC cis rs7927771 0.524 rs4539273 chr11:47694699 C/T cg20307385 chr11:47447363 PSMC3 -0.49 -7.32 -0.37 1.97e-12 Subjective well-being; CRC cis rs10479542 0.784 rs4701132 chr5:178985270 A/G cg22764044 chr5:178986830 RUFY1 -0.45 -7.88 -0.4 4.71e-14 Lung cancer; CRC cis rs6502050 0.835 rs8065565 chr17:80115399 A/G cg02741985 chr17:80059408 CCDC57 0.43 7.18 0.37 4.56e-12 Life satisfaction; CRC cis rs9858542 0.953 rs1987628 chr3:49399259 G/A cg07274523 chr3:49395745 GPX1 0.46 6.23 0.32 1.46e-9 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs10504229 0.683 rs73605816 chr8:58117167 T/C cg21724239 chr8:58056113 NA 0.49 6.81 0.35 4.75e-11 Developmental language disorder (linguistic errors); CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg01077085 chr5:126112750 LMNB1 0.45 6.23 0.32 1.46e-9 Anxiety disorder; CRC cis rs17666538 1.000 rs61064968 chr8:587933 T/C cg07234876 chr8:600039 NA -0.93 -8.14 -0.41 8.53e-15 IgG glycosylation; CRC cis rs4664293 0.625 rs4664295 chr2:160520318 G/A cg08347373 chr2:160653686 CD302 0.39 6.58 0.34 1.91e-10 Monocyte percentage of white cells; CRC cis rs873946 0.586 rs12767391 chr10:134573844 A/G cg18305652 chr10:134549665 INPP5A -0.45 -5.86 -0.31 1.15e-8 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CRC cis rs12545109 0.800 rs1530217 chr8:57408097 C/T cg09654669 chr8:57350985 NA -0.41 -5.71 -0.3 2.51e-8 Obesity-related traits; CRC cis rs2274471 0.645 rs2104685 chr9:5106023 A/T cg03390472 chr9:5043263 JAK2 -0.53 -6.38 -0.33 6.13e-10 Crohn's disease; CRC cis rs7615952 0.641 rs12487875 chr3:125787224 C/A cg02772935 chr3:125709198 NA -0.48 -5.7 -0.3 2.66e-8 Blood pressure (smoking interaction); CRC cis rs11711311 1.000 rs2603792 chr3:113509187 G/A cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.53 -7.33 -0.37 1.75e-12 IgG glycosylation; CRC trans rs459571 0.959 rs456205 chr9:136911146 G/A cg15028160 chr19:49622717 PPFIA3;C19orf73 -0.55 -6.82 -0.35 4.33e-11 Platelet distribution width; CRC cis rs4332037 0.539 rs868754 chr7:2033780 G/C cg23422044 chr7:1970798 MAD1L1 -0.62 -7.17 -0.37 5.01e-12 Bipolar disorder; CRC cis rs897984 0.609 rs1108431 chr16:31054607 C/T cg02466173 chr16:30829666 NA -0.66 -10.11 -0.49 4.1e-21 Dementia with Lewy bodies; CRC cis rs56399783 0.901 rs73049327 chr7:2795544 T/G cg23627948 chr7:2760692 NA 0.47 5.66 0.3 3.34e-8 Childhood ear infection; CRC cis rs736408 0.648 rs3774354 chr3:52817675 G/A cg07507251 chr3:52567010 NT5DC2 0.48 6.64 0.34 1.29e-10 Bipolar disorder; CRC cis rs736408 0.736 rs4687550 chr3:52823430 T/G cg08222913 chr3:52553049 STAB1 -0.34 -5.8 -0.3 1.55e-8 Bipolar disorder; CRC cis rs1712517 0.844 rs1163074 chr10:105021762 C/T cg05636881 chr10:105038444 INA 0.47 8.44 0.42 1.05e-15 Migraine; CRC cis rs35264875 0.851 rs72930621 chr11:68866745 C/T cg01993067 chr11:68851601 TPCN2 0.51 6.03 0.32 4.33e-9 Blond vs. brown hair color; CRC cis rs9916302 0.706 rs801418 chr17:37457982 G/C cg07936489 chr17:37558343 FBXL20 0.84 10.61 0.5 8.08e-23 Glomerular filtration rate (creatinine); CRC cis rs13064411 0.696 rs7610638 chr3:113139656 A/G cg18753928 chr3:113234510 CCDC52 -0.64 -8.92 -0.44 3.24e-17 Response to simvastatin treatment (PCSK9 protein level change); CRC cis rs1865760 0.508 rs9379820 chr6:26049924 T/C cg16482183 chr6:26056742 HIST1H1C 0.52 7.48 0.38 6.66e-13 Height; CRC trans rs1005277 0.579 rs1780133 chr10:38499509 T/C cg17830980 chr10:43048298 ZNF37B -0.57 -9.63 -0.47 1.63e-19 Extrinsic epigenetic age acceleration; CRC cis rs10089 0.951 rs56066100 chr5:127460571 G/C cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.72 9.97 0.48 1.28e-20 Ileal carcinoids; CRC cis rs11122272 0.766 rs2739511 chr1:231526490 G/C cg06096015 chr1:231504339 EGLN1 0.39 5.89 0.31 9.62e-9 Hemoglobin concentration; CRC cis rs875971 0.862 rs13232191 chr7:65986648 A/G cg12463550 chr7:65579703 CRCP 0.47 6.45 0.33 4.03e-10 Aortic root size; CRC trans rs17685 0.697 rs2302437 chr7:75677016 G/A cg19862616 chr7:65841803 NCRNA00174 -0.99 -18.5 -0.71 7.22e-53 Coffee consumption;Coffee consumption (cups per day); CRC cis rs7202877 0.572 rs4888371 chr16:75308781 G/A cg03315344 chr16:75512273 CHST6 0.47 5.74 0.3 2.15e-8 Type 2 diabetes;Type 1 diabetes; CRC cis rs2806561 0.765 rs1738469 chr1:23511407 G/C cg12483005 chr1:23474871 LUZP1 0.5 7.23 0.37 3.35e-12 Height; CRC cis rs7666738 0.830 rs13108705 chr4:99044438 T/C cg17366294 chr4:99064904 C4orf37 0.45 7.73 0.39 1.34e-13 Colonoscopy-negative controls vs population controls; CRC trans rs8002861 0.870 rs4942254 chr13:44451820 C/T cg17145862 chr1:211918768 LPGAT1 0.71 14.28 0.62 2.39e-36 Leprosy; CRC cis rs720844 0.554 rs12615224 chr2:149297441 C/G cg09247360 chr2:149335327 NA -0.42 -5.7 -0.3 2.64e-8 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs9914988 0.943 rs2046759 chr17:27138817 T/C cg20469991 chr17:27169893 C17orf63 -0.6 -7.22 -0.37 3.6e-12 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs4713118 0.869 rs2056925 chr6:27690905 A/G cg21251018 chr6:28226885 NKAPL 0.38 5.72 0.3 2.34e-8 Parkinson's disease; CRC cis rs3820068 0.705 rs4646077 chr1:15827136 C/T cg27534772 chr1:16042836 PLEKHM2 0.41 6.95 0.36 1.99e-11 Systolic blood pressure; CRC cis rs7412746 0.658 rs4970982 chr1:150865084 G/C cg15448220 chr1:150897856 SETDB1 0.56 8.19 0.41 6.03e-15 Melanoma; CRC cis rs7814319 1.000 rs6468495 chr8:97259953 C/A cg20787634 chr8:97240163 UQCRB -0.56 -9.68 -0.47 1.15e-19 Lung function (FVC); CRC cis rs4713118 0.527 rs36042294 chr6:27720712 C/G cg12172441 chr6:28176163 NA 0.47 6.53 0.34 2.49e-10 Parkinson's disease; CRC cis rs7666738 0.830 rs4292341 chr4:98959724 C/T cg05340658 chr4:99064831 C4orf37 0.63 9.61 0.47 1.93e-19 Colonoscopy-negative controls vs population controls; CRC cis rs780096 0.565 rs8179252 chr2:27746832 A/C cg27432699 chr2:27873401 GPN1 -0.62 -9.86 -0.48 2.97e-20 Total body bone mineral density; CRC cis rs11711311 0.955 rs34048496 chr3:113414121 C/T cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.49 -6.38 -0.33 6.12e-10 IgG glycosylation; CRC cis rs10504229 1.000 rs77857677 chr8:58170131 G/A cg24829409 chr8:58192753 C8orf71 -0.68 -11.34 -0.53 2.27e-25 Developmental language disorder (linguistic errors); CRC cis rs7940866 0.646 rs10894293 chr11:130824213 C/T cg12179176 chr11:130786555 SNX19 -0.59 -8.3 -0.42 2.71e-15 Schizophrenia; CRC cis rs344364 0.511 rs1742463 chr16:1946110 A/G cg09830162 chr16:1889614 FAHD1;C16orf73 -0.74 -9.05 -0.45 1.3e-17 Glomerular filtration rate in chronic kidney disease; CRC cis rs6570726 0.791 rs6918814 chr6:145906028 G/A cg23711669 chr6:146136114 FBXO30 0.63 10.66 0.51 5.44e-23 Lobe attachment (rater-scored or self-reported); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg18913729 chr8:97274064 MTERFD1;PTDSS1 0.46 6.63 0.34 1.36e-10 Intelligence (multi-trait analysis); CRC cis rs55823223 0.564 rs4572466 chr17:73846314 A/C cg24416660 chr17:73865998 NA -0.38 -5.76 -0.3 1.98e-8 Psoriasis; CRC cis rs7666738 0.800 rs2865988 chr4:99067807 T/C cg17366294 chr4:99064904 C4orf37 0.43 7.32 0.37 1.87e-12 Colonoscopy-negative controls vs population controls; CRC cis rs8072100 0.764 rs4794371 chr17:45627693 G/C cg08085267 chr17:45401833 C17orf57 0.63 10.12 0.49 3.85e-21 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs9287719 0.967 rs4470306 chr2:10743998 C/T cg00105475 chr2:10696890 NA 0.45 7.3 0.37 2.19e-12 Prostate cancer; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg11317019 chr17:42219250 C17orf53 0.45 6.38 0.33 6.03e-10 Response to antipsychotic treatment; CRC cis rs208520 0.690 rs12213581 chr6:66735818 T/C cg07460842 chr6:66804631 NA 1.06 14.74 0.63 4.07e-38 Exhaled nitric oxide output; CRC cis rs11645898 0.935 rs11647125 chr16:72243277 T/C cg14768367 chr16:72042858 DHODH -0.6 -6.77 -0.35 5.97e-11 Blood protein levels; CRC cis rs875971 0.545 rs4718325 chr7:65680310 G/A cg05627663 chr7:65219948 SNORA22;CCT6P1 0.64 8.34 0.42 2.11e-15 Aortic root size; CRC cis rs262150 0.659 rs2527237 chr7:158798494 A/G cg07130601 chr7:158766826 NA -0.4 -5.78 -0.3 1.76e-8 Facial morphology (factor 20); CRC cis rs17001868 0.568 rs9611325 chr22:40782490 G/A cg07138101 chr22:40742427 ADSL 0.58 7.88 0.4 4.69e-14 Mammographic density (dense area); CRC cis rs3096299 0.874 rs3102342 chr16:89451575 T/C cg01788221 chr16:89496183 ANKRD11 -0.39 -5.9 -0.31 8.8e-9 Multiple myeloma (IgH translocation); CRC cis rs9311474 0.508 rs6786919 chr3:52599789 A/G cg18099408 chr3:52552593 STAB1 -0.48 -8.3 -0.42 2.81e-15 Electroencephalogram traits; CRC cis rs10256972 0.552 rs7805591 chr7:1210745 A/G cg16145915 chr7:1198662 ZFAND2A -0.5 -10.39 -0.5 4.81e-22 Longevity;Endometriosis; CRC cis rs364477 0.904 rs279900 chr9:963897 G/C cg13952963 chr9:998547 NA 0.57 6.13 0.32 2.53e-9 Major depressive disorder; CRC cis rs1692580 0.682 rs12045693 chr1:2205581 A/C cg24578937 chr1:2090814 PRKCZ -0.37 -6.9 -0.36 2.61e-11 Coronary artery disease; CRC cis rs4664293 0.625 rs11899419 chr2:160545369 A/G cg08347373 chr2:160653686 CD302 0.39 6.7 0.35 9.05e-11 Monocyte percentage of white cells; CRC cis rs2075371 1.000 rs2075372 chr7:133984432 C/T cg11752832 chr7:134001865 SLC35B4 0.5 7.71 0.39 1.54e-13 Mean platelet volume; CRC cis rs9287719 0.614 rs10929678 chr2:10723095 T/C cg00105475 chr2:10696890 NA 0.47 7.24 0.37 3.19e-12 Prostate cancer; CRC trans rs9395066 0.545 rs10484627 chr6:44884267 A/T cg04786201 chr1:17185605 NA 0.28 6.03 0.32 4.49e-9 Height; CRC cis rs9868809 0.505 rs9877685 chr3:48748588 C/T cg00383909 chr3:49044727 WDR6 0.79 8.04 0.41 1.68e-14 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; CRC cis rs68170813 0.559 rs77150993 chr7:106817100 G/T cg02696742 chr7:106810147 HBP1 -0.62 -6.81 -0.35 4.67e-11 Coronary artery disease; CRC cis rs2832191 0.692 rs2245517 chr21:30357968 C/T cg08807101 chr21:30365312 RNF160 0.73 11.75 0.54 7.2e-27 Dental caries; CRC cis rs597539 0.617 rs669659 chr11:68635623 G/C cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.89 15.84 0.66 2.17e-42 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs7951870 0.617 rs7932354 chr11:46722221 T/C cg19486271 chr11:47235900 DDB2 -0.49 -7.68 -0.39 1.89e-13 Schizophrenia; CRC trans rs7726839 0.507 rs56282020 chr5:596701 T/C cg25482853 chr8:67687455 SGK3 1.09 12.84 0.58 7.36e-31 Obesity-related traits; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg08869571 chr19:12076348 ZNF763 0.33 6.23 0.32 1.42e-9 Intelligence (multi-trait analysis); CRC trans rs7615952 0.546 rs2979333 chr3:125360343 T/A cg02007433 chr3:129722099 NA -0.5 -6.22 -0.32 1.48e-9 Blood pressure (smoking interaction); CRC cis rs873946 0.557 rs34854637 chr10:134582962 A/G cg06453172 chr10:134556979 INPP5A -0.62 -7.48 -0.38 7.04e-13 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CRC cis rs4481887 0.708 rs28729425 chr1:248563027 T/C cg00666640 chr1:248458726 OR2T12 0.39 7.2 0.37 4.13e-12 Common traits (Other); CRC cis rs7552404 0.727 rs1159214 chr1:76317910 G/T cg22875332 chr1:76189707 ACADM -0.56 -7.4 -0.38 1.15e-12 Blood metabolite levels;Acylcarnitine levels; CRC cis rs11971779 0.616 rs10278377 chr7:139103071 G/A cg07862535 chr7:139043722 LUC7L2 0.57 7.32 0.37 1.92e-12 Diisocyanate-induced asthma; CRC trans rs116095464 0.558 rs7708515 chr5:234989 C/G cg00938859 chr5:1591904 SDHAP3 0.72 7.95 0.4 3.01e-14 Breast cancer; CRC cis rs9811920 0.609 rs9817005 chr3:99682692 T/C cg07805332 chr3:99536008 MIR548G;C3orf26 0.51 7.66 0.39 2.03e-13 Axial length; CRC cis rs7224685 0.501 rs2676276 chr17:3919981 C/T cg05562828 chr17:3906858 NA -0.67 -13.23 -0.59 2.49e-32 Type 2 diabetes; CRC cis rs2180341 0.782 rs4897214 chr6:127723625 G/T cg27446573 chr6:127587934 RNF146 0.72 10.03 0.48 8.03e-21 Breast cancer; CRC cis rs4731207 0.564 rs12531844 chr7:124603900 C/G cg23710748 chr7:124431027 NA -0.38 -6.08 -0.32 3.35e-9 Cutaneous malignant melanoma; CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg04866628 chr4:187026225 NA -0.58 -7.22 -0.37 3.59e-12 Diisocyanate-induced asthma; CRC cis rs1153858 0.943 rs67045941 chr15:45677011 A/G cg21132104 chr15:45694354 SPATA5L1 0.59 8.56 0.43 4.47e-16 Homoarginine levels; CRC cis rs9469578 1.000 rs73743328 chr6:33713550 G/A cg18708504 chr6:33715942 IP6K3 0.66 7.56 0.38 4e-13 Phosphorus levels; CRC cis rs172166 0.694 rs188105 chr6:28071393 C/T cg02631126 chr6:28058918 ZSCAN12L1 0.24 5.69 0.3 2.82e-8 Cardiac Troponin-T levels; CRC trans rs6703335 0.870 rs10803142 chr1:243598234 A/G cg04865672 chr1:161087935 NIT1;PFDN2 0.43 6.07 0.32 3.52e-9 Schizophrenia;Schizophrenia, schizoaffective disorder or bipolar disorder; CRC cis rs9467711 0.606 rs9393707 chr6:26362486 T/C cg16898833 chr6:26189333 HIST1H4D 0.75 6.55 0.34 2.26e-10 Autism spectrum disorder or schizophrenia; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg04376719 chr19:1028379 CNN2 0.43 6.15 0.32 2.28e-9 Intelligence (multi-trait analysis); CRC cis rs7202877 0.656 rs4888374 chr16:75322228 T/C cg03315344 chr16:75512273 CHST6 0.52 6.04 0.32 4.22e-9 Type 2 diabetes;Type 1 diabetes; CRC cis rs6951245 0.938 rs11764937 chr7:1092074 C/T cg21664854 chr7:1097933 C7orf50;GPR146 0.7 7.88 0.4 4.95e-14 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs2011503 1.000 rs11085264 chr19:19621780 A/G cg11584989 chr19:19387371 SF4 0.57 6.39 0.33 5.7e-10 Bipolar disorder; CRC cis rs317689 0.613 rs315112 chr12:69785926 T/A cg20891283 chr12:69753455 YEATS4 0.71 10.02 0.48 8.31e-21 Response to diuretic therapy; CRC cis rs11167764 1.000 rs3761757 chr5:141488219 A/C cg23435118 chr5:141488016 NDFIP1 -0.46 -7.39 -0.38 1.18e-12 Crohn's disease; CRC cis rs6582630 0.537 rs7299661 chr12:38527713 C/T cg13010199 chr12:38710504 ALG10B 0.48 6.59 0.34 1.73e-10 Drug-induced liver injury (flucloxacillin); CRC cis rs17065868 0.764 rs7317779 chr13:45024461 A/C cg10246903 chr13:45222710 NA 0.56 6.29 0.33 1.03e-9 Antineutrophil cytoplasmic antibody-associated vasculitis; CRC cis rs9393692 0.620 rs9357005 chr6:26336838 C/A cg00631329 chr6:26305371 NA -0.56 -9.3 -0.46 2.02e-18 Educational attainment; CRC trans rs7615952 0.599 rs66532274 chr3:125731845 G/A cg07211511 chr3:129823064 LOC729375 -0.79 -12.53 -0.57 1.05e-29 Blood pressure (smoking interaction); CRC trans rs6600671 0.967 rs11249347 chr1:121188347 G/T cg00646200 chr1:148855367 NA 0.34 6.2 0.32 1.72e-9 Hip geometry; CRC cis rs947211 1.000 rs823144 chr1:205744546 C/A cg24503407 chr1:205819492 PM20D1 0.46 6.42 0.33 4.72e-10 Parkinson's disease; CRC cis rs3087591 0.639 rs2342052 chr17:29721011 T/C cg24425628 chr17:29625626 OMG;NF1 0.71 13.05 0.58 1.18e-31 Hip circumference; CRC trans rs1005277 0.540 rs1987431 chr10:37988887 T/C cg17830980 chr10:43048298 ZNF37B -0.42 -6.47 -0.34 3.55e-10 Extrinsic epigenetic age acceleration; CRC cis rs12580194 0.556 rs7955088 chr12:55732963 G/T cg19537932 chr12:55886519 OR6C68 -0.65 -8.38 -0.42 1.53e-15 Cancer; CRC cis rs4862750 0.874 rs6553027 chr4:187875777 T/C cg27532560 chr4:187881888 NA -0.54 -9.79 -0.47 5.04e-20 Lobe attachment (rater-scored or self-reported); CRC cis rs1953600 0.729 rs2819872 chr10:81906269 A/G cg00277334 chr10:82204260 NA 0.38 6.45 0.34 3.91e-10 Sarcoidosis; CRC cis rs9467773 1.000 rs9467778 chr6:26534743 T/C cg09904177 chr6:26538194 HMGN4 0.86 14.9 0.63 9.92e-39 Intelligence (multi-trait analysis); CRC cis rs9549367 0.664 rs9549689 chr13:113848387 G/A cg00898013 chr13:113819073 PROZ -0.59 -8.21 -0.41 5.1e-15 Platelet distribution width; CRC cis rs2842992 0.872 rs2758315 chr6:160158640 T/C cg11366901 chr6:160182831 ACAT2 0.97 14.22 0.62 4.19e-36 Age-related macular degeneration (geographic atrophy); CRC cis rs4631830 0.863 rs10826127 chr10:51530757 G/A cg20129853 chr10:51489980 NA -0.35 -5.7 -0.3 2.67e-8 Prostate-specific antigen levels; CRC cis rs11958404 0.932 rs72816595 chr5:157435957 A/G cg05962755 chr5:157440814 NA 1.01 12.88 0.58 5.12e-31 IgG glycosylation; CRC cis rs758324 0.773 rs11951407 chr5:131142661 T/C cg25547332 chr5:131281432 NA 0.35 5.61 0.3 4.31e-8 Alzheimer's disease in APOE e4- carriers; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg21187239 chr8:97247397 UQCRB 0.44 6.15 0.32 2.22e-9 Response to antipsychotic treatment; CRC cis rs7659604 0.539 rs11731917 chr4:122783233 G/A cg19748678 chr4:122722346 EXOSC9 0.65 10.2 0.49 2.12e-21 Type 2 diabetes; CRC cis rs644148 0.738 rs2686768 chr19:44995990 C/T cg15540054 chr19:45004280 ZNF180 -0.41 -5.74 -0.3 2.14e-8 Personality dimensions; CRC cis rs6570726 0.791 rs13202312 chr6:145913093 T/G cg13319975 chr6:146136371 FBXO30 -0.44 -6.44 -0.33 4.13e-10 Lobe attachment (rater-scored or self-reported); CRC cis rs6815814 0.861 rs12233670 chr4:38787216 C/T cg06935464 chr4:38784597 TLR10 0.69 9.02 0.45 1.61e-17 Breast cancer; CRC cis rs1862618 0.620 rs2591967 chr5:56233551 C/G cg12311346 chr5:56204834 C5orf35 0.65 9.7 0.47 9.54e-20 Initial pursuit acceleration; CRC cis rs875971 0.545 rs73142233 chr7:65686280 T/A cg18876405 chr7:65276391 NA 0.47 6.49 0.34 3.08e-10 Aortic root size; CRC cis rs853679 0.517 rs9283884 chr6:28135660 C/G cg03623178 chr6:28175578 NA -0.95 -11.97 -0.55 1.22e-27 Depression; CRC cis rs4561483 0.801 rs40311 chr16:11963190 C/G cg08843971 chr16:11963173 GSPT1 0.67 10.76 0.51 2.41e-23 Testicular germ cell tumor; CRC cis rs17401966 0.597 rs2180185 chr1:10246129 C/G cg19773385 chr1:10388646 KIF1B -0.47 -7.44 -0.38 8.93e-13 Hepatocellular carcinoma; CRC cis rs6088580 0.634 rs4911419 chr20:32995873 G/A cg08999081 chr20:33150536 PIGU -0.61 -11.54 -0.54 4.11e-26 Glomerular filtration rate (creatinine); CRC cis rs58688157 0.705 rs11539530 chr11:609353 G/A cg01842473 chr11:617407 IRF7;MUPCDH -0.55 -6.55 -0.34 2.23e-10 Systemic lupus erythematosus; CRC cis rs9858542 0.953 rs9837027 chr3:49597013 C/T cg03060546 chr3:49711283 APEH -0.46 -6.45 -0.34 3.95e-10 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC trans rs6550704 0.687 rs9865314 chr3:22634337 A/G cg08652108 chr6:44443600 NA -0.43 -6.08 -0.32 3.35e-9 Daytime sleep phenotypes; CRC cis rs4929949 0.902 rs61875898 chr11:8627224 C/A cg02811074 chr11:8615871 STK33 0.34 5.78 0.3 1.74e-8 Body mass index; CRC cis rs853679 0.506 rs1150693 chr6:28174590 T/C cg21251018 chr6:28226885 NKAPL 0.46 6.45 0.34 3.99e-10 Depression; CRC cis rs2067615 0.831 rs1922437 chr12:107058045 C/T cg13491945 chr12:107078410 RFX4 0.33 5.68 0.3 2.94e-8 Heart rate; CRC cis rs6772849 0.930 rs12487604 chr3:128337075 T/A cg08795948 chr3:128337044 NA 0.39 6.6 0.34 1.66e-10 Monocyte percentage of white cells;Monocyte count; CRC cis rs995000 0.839 rs12090886 chr1:62981440 G/A cg19896129 chr1:63156450 NA -0.39 -6.0 -0.31 5.21e-9 Triglyceride levels; CRC cis rs13315871 0.929 rs71311853 chr3:58319152 C/T cg20936604 chr3:58311152 NA -0.75 -7.05 -0.36 1.05e-11 Cholesterol, total; CRC cis rs6951245 0.935 rs76525951 chr7:1096013 C/T cg04025307 chr7:1156635 C7orf50 0.63 6.74 0.35 7.02e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs7940866 0.874 rs7111478 chr11:130819628 A/G cg12179176 chr11:130786555 SNX19 0.61 8.98 0.44 2.09e-17 Schizophrenia; CRC cis rs5758511 0.573 rs1883205 chr22:42243020 A/G cg00645731 chr22:42541494 CYP2D7P1 -0.38 -6.16 -0.32 2.08e-9 Birth weight; CRC trans rs17270561 0.636 rs1165216 chr6:25797971 G/A cg02936872 chr9:99801550 CTSL2 0.48 6.18 0.32 1.85e-9 Iron status biomarkers; CRC cis rs919433 0.963 rs10199410 chr2:198155776 A/T cg10820045 chr2:198174542 NA -0.57 -11.38 -0.53 1.66e-25 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC cis rs798554 0.567 rs2527695 chr7:2858267 T/G cg17321639 chr7:2759063 NA -0.37 -5.72 -0.3 2.42e-8 Height; CRC cis rs7666738 0.791 rs6833691 chr4:98951508 A/G cg17366294 chr4:99064904 C4orf37 0.43 7.34 0.38 1.69e-12 Colonoscopy-negative controls vs population controls; CRC trans rs9858542 0.953 rs35261698 chr3:49537839 C/G cg21665057 chr3:196295764 WDR53;FBXO45 -0.66 -9.1 -0.45 8.6e-18 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs7927771 0.832 rs10769262 chr11:47411581 G/A cg18512352 chr11:47633146 NA 0.39 7.37 0.38 1.4e-12 Subjective well-being; CRC trans rs4650994 0.505 rs2811291 chr1:178574217 C/T cg05059571 chr16:84539110 KIAA1609 0.63 8.62 0.43 2.88e-16 HDL cholesterol levels;HDL cholesterol; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg03610000 chr11:128392383 ETS1 0.42 7.1 0.36 7.75e-12 Liver disease severity in Alagille syndrome; CRC cis rs6860806 0.661 rs2171247 chr5:131580234 G/T cg11843238 chr5:131593191 PDLIM4 0.42 7.94 0.4 3.14e-14 Breast cancer; CRC cis rs5753037 0.564 rs131298 chr22:30180001 C/T cg01021169 chr22:30184971 ASCC2 0.4 6.29 0.33 9.87e-10 Type 1 diabetes; CRC cis rs6076065 0.723 rs6137909 chr20:23344728 A/G cg11657817 chr20:23433608 CST11 0.43 6.25 0.33 1.31e-9 Facial morphology (factor 15, philtrum width); CRC cis rs798554 0.660 rs2644274 chr7:2854380 A/T cg04166393 chr7:2884313 GNA12 0.38 5.72 0.3 2.43e-8 Height; CRC cis rs6912958 0.712 rs6930600 chr6:88349787 G/A cg08069147 chr6:88032118 GJB7;C6orf162 -0.56 -8.42 -0.42 1.16e-15 Monocyte percentage of white cells; CRC cis rs8180040 0.620 rs1811652 chr3:47208698 C/G cg10298567 chr3:47292165 KIF9 0.4 6.25 0.33 1.3e-9 Colorectal cancer; CRC cis rs1059312 0.966 rs12370194 chr12:129277250 A/T cg21616243 chr12:129299702 MGC16384;SLC15A4 -0.65 -10.62 -0.51 7.56e-23 Systemic lupus erythematosus; CRC cis rs10256972 0.758 rs9801444 chr7:1080444 A/C cg23708337 chr7:1209742 NA -0.39 -5.87 -0.31 1.06e-8 Longevity;Endometriosis; CRC cis rs6502050 0.635 rs11867440 chr17:80147185 A/T cg25804541 chr17:80189381 SLC16A3 -0.31 -5.9 -0.31 8.81e-9 Life satisfaction; CRC cis rs1218582 0.772 rs906593 chr1:154885255 G/A cg24250549 chr1:154909240 PMVK 0.65 11.3 0.53 3.18e-25 Prostate cancer; CRC cis rs736801 0.754 rs2706336 chr5:131799961 T/C cg00255919 chr5:131827918 IRF1 0.36 6.11 0.32 2.81e-9 Breast cancer;Mosquito bite size; CRC cis rs10779751 1.000 rs718206 chr1:11294474 T/A cg08854313 chr1:11322531 MTOR 0.68 9.71 0.47 9.38e-20 Body mass index; CRC cis rs2688608 0.592 rs13013 chr10:75562161 C/A cg16540259 chr10:75572220 NDST2 0.38 6.15 0.32 2.21e-9 Inflammatory bowel disease; CRC cis rs11105298 0.891 rs10858903 chr12:89927972 G/A cg00757033 chr12:89920650 WDR51B 0.38 6.35 0.33 7.15e-10 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; CRC cis rs2933343 0.700 rs1680788 chr3:128625318 C/T cg11901034 chr3:128598214 ACAD9 -0.56 -8.11 -0.41 1.01e-14 IgG glycosylation; CRC cis rs9322193 0.923 rs9767554 chr6:149937996 T/C cg13206674 chr6:150067644 NUP43 0.63 9.32 0.46 1.69e-18 Lung cancer; CRC cis rs34779708 0.931 rs7923217 chr10:35309589 A/G cg03585969 chr10:35415529 CREM 0.58 7.82 0.4 7.34e-14 Inflammatory bowel disease;Crohn's disease; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg00145757 chr11:118478637 PHLDB1 0.47 6.57 0.34 1.92e-10 Response to antipsychotic treatment; CRC cis rs9457247 1.000 rs239935 chr6:167411788 G/A cg23791538 chr6:167370224 RNASET2 -0.38 -5.86 -0.31 1.15e-8 Crohn's disease; CRC cis rs992157 1.000 rs4791 chr2:219138940 C/T cg04731861 chr2:219085781 ARPC2 -0.27 -5.69 -0.3 2.86e-8 Colorectal cancer; CRC cis rs2976388 1.000 rs2976394 chr8:143763622 C/T cg20041105 chr8:143859282 LYNX1 -0.32 -5.65 -0.3 3.45e-8 Urinary tract infection frequency; CRC cis rs7772486 0.754 rs2328707 chr6:146053498 G/A cg13319975 chr6:146136371 FBXO30 0.46 6.79 0.35 5.29e-11 Lobe attachment (rater-scored or self-reported); CRC cis rs2976388 0.609 rs2263092 chr8:143789966 A/G cg20041105 chr8:143859282 LYNX1 0.46 8.31 0.42 2.48e-15 Urinary tract infection frequency; CRC cis rs28386778 0.897 rs7212196 chr17:61834981 T/C cg00280220 chr17:61926910 NA 0.34 5.65 0.3 3.49e-8 Prudent dietary pattern; CRC cis rs311392 0.871 rs402088 chr8:55092805 A/G cg20636351 chr8:55087400 NA -0.33 -5.96 -0.31 6.62e-9 Pelvic organ prolapse (moderate/severe); CRC cis rs600231 0.706 rs3782091 chr11:65336483 G/T cg17120908 chr11:65337727 SSSCA1 0.61 8.99 0.44 2e-17 Bone mineral density; CRC cis rs2645694 0.626 rs2703122 chr4:77821418 A/C cg03477792 chr4:77819574 ANKRD56 0.44 6.37 0.33 6.51e-10 Emphysema distribution in smoking; CRC cis rs6546550 0.935 rs6747542 chr2:70106832 T/C cg02498382 chr2:70120550 SNRNP27 -0.39 -6.34 -0.33 7.58e-10 Prevalent atrial fibrillation; CRC cis rs7666738 0.791 rs2903142 chr4:99040071 C/T cg05340658 chr4:99064831 C4orf37 0.6 9.35 0.46 1.36e-18 Colonoscopy-negative controls vs population controls; CRC cis rs1862618 0.853 rs11739344 chr5:56111087 A/C cg03609598 chr5:56110824 MAP3K1 -0.81 -9.7 -0.47 9.66e-20 Initial pursuit acceleration; CRC cis rs561341 1.000 rs564714 chr17:30318404 C/T cg19193384 chr17:30244184 NA -0.66 -7.59 -0.39 3.4e-13 Hip circumference adjusted for BMI; CRC cis rs4853012 0.838 rs61521879 chr2:74346208 T/C cg19729930 chr2:74357872 NA 0.61 9.47 0.46 5.78e-19 Gestational age at birth (maternal effect); CRC cis rs10791097 0.667 rs12363163 chr11:130744509 A/G cg12179176 chr11:130786555 SNX19 0.75 12.66 0.57 3.46e-30 Autism spectrum disorder or schizophrenia;Schizophrenia; CRC cis rs4713118 0.662 rs156744 chr6:27967274 G/A cg02683197 chr6:28174875 NA 0.7 9.57 0.47 2.57e-19 Parkinson's disease; CRC trans rs6550704 0.687 rs9865314 chr3:22634337 A/G cg05886006 chr1:161359784 NA -0.4 -5.98 -0.31 5.98e-9 Daytime sleep phenotypes; CRC cis rs2797160 1.000 rs1935774 chr6:125996661 A/G cg05901451 chr6:126070800 HEY2 0.43 6.45 0.33 4.02e-10 Endometrial cancer; CRC cis rs883565 0.569 rs7614000 chr3:39152575 C/G cg01426195 chr3:39028469 NA -0.42 -6.99 -0.36 1.56e-11 Handedness; CRC cis rs6460942 0.908 rs73677573 chr7:12283598 G/A cg06484146 chr7:12443880 VWDE -0.64 -6.66 -0.34 1.18e-10 Coronary artery disease; CRC cis rs2559856 1.000 rs10745921 chr12:102087193 A/G cg12924262 chr12:102091054 CHPT1 0.55 8.26 0.41 3.58e-15 Blood protein levels; CRC cis rs1862618 0.853 rs832554 chr5:56115036 A/G cg22800045 chr5:56110881 MAP3K1 0.56 6.19 0.32 1.75e-9 Initial pursuit acceleration; CRC cis rs17384381 1.000 rs1608536 chr1:85885836 C/T cg16011679 chr1:85725395 C1orf52 0.65 6.68 0.35 1.05e-10 Lobe attachment (rater-scored or self-reported); CRC cis rs8072100 0.840 rs12453233 chr17:45454570 C/T cg25173405 chr17:45401733 C17orf57 -0.52 -8.25 -0.41 3.78e-15 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC trans rs10504229 0.911 rs77203035 chr8:58175458 C/A cg04077850 chr5:125800366 GRAMD3 0.37 6.27 0.33 1.15e-9 Developmental language disorder (linguistic errors); CRC trans rs1973993 0.745 rs7512263 chr1:96941158 C/A cg10631902 chr5:14652156 NA -0.42 -6.87 -0.35 3.26e-11 Weight; CRC cis rs1707322 0.963 rs4553121 chr1:46375253 G/A cg06784218 chr1:46089804 CCDC17 0.52 9.12 0.45 7.88e-18 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs7959452 0.535 rs2305641 chr12:69646914 C/T cg14784868 chr12:69753453 YEATS4 0.74 12.3 0.56 7.25e-29 Blood protein levels; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg10192736 chr19:1028627 CNN2 0.41 6.21 0.32 1.58e-9 Intelligence (multi-trait analysis); CRC cis rs7772486 0.720 rs6570713 chr6:146075085 G/A cg13319975 chr6:146136371 FBXO30 0.45 6.64 0.34 1.27e-10 Lobe attachment (rater-scored or self-reported); CRC cis rs4919087 1.000 rs10786327 chr10:99071408 C/T cg25902810 chr10:99078978 FRAT1 0.39 5.98 0.31 5.67e-9 Monocyte count; CRC cis rs4332037 0.615 rs62435134 chr7:1895463 T/G cg25834613 chr7:1915315 MAD1L1 -0.44 -6.41 -0.33 5.18e-10 Bipolar disorder; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg22559639 chr12:53895182 TARBP2 0.36 6.62 0.34 1.43e-10 Liver disease severity in Alagille syndrome; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg15433164 chr3:25824899 NGLY1 0.33 6.45 0.34 4.05e-10 Liver disease severity in Alagille syndrome; CRC cis rs2882667 0.838 rs11958529 chr5:138395068 C/T cg04439458 chr5:138467593 SIL1 -0.33 -5.99 -0.31 5.59e-9 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs9549367 0.713 rs2480949 chr13:113853149 T/C cg00898013 chr13:113819073 PROZ 0.5 7.43 0.38 9.39e-13 Platelet distribution width; CRC cis rs9928842 0.722 rs1035540 chr16:75278795 A/G cg09066997 chr16:75300724 BCAR1 0.71 7.02 0.36 1.27e-11 Alcoholic chronic pancreatitis; CRC cis rs6831352 0.918 rs2602893 chr4:100044095 G/T cg12011299 chr4:100065546 ADH4 0.49 9.28 0.46 2.34e-18 Alcohol dependence; CRC cis rs910187 1.000 rs910187 chr20:45841052 A/G cg27589058 chr20:45804311 EYA2 0.35 6.37 0.33 6.47e-10 Migraine; CRC cis rs17826219 0.636 rs4055314 chr17:29079769 T/C cg01831904 chr17:28903510 LRRC37B2 -0.62 -6.41 -0.33 5.05e-10 Body mass index; CRC cis rs501916 0.833 rs11629796 chr15:48045248 A/G cg16110827 chr15:48056943 SEMA6D -0.47 -7.17 -0.37 4.99e-12 Inflammatory bowel disease;Ulcerative colitis; CRC cis rs861020 0.630 rs685248 chr1:210008367 C/G cg09163369 chr1:210001066 C1orf107 0.41 5.75 0.3 2.05e-8 Orofacial clefts; CRC cis rs4481887 0.573 rs10888329 chr1:248404654 C/T cg00666640 chr1:248458726 OR2T12 -0.41 -6.55 -0.34 2.16e-10 Common traits (Other); CRC cis rs7632954 1.000 rs9811322 chr3:8524337 T/C cg03495237 chr3:8533978 NA 0.33 5.89 0.31 9.64e-9 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs477895 0.653 rs2875749 chr11:63903878 C/A cg23719950 chr11:63933701 MACROD1 -0.65 -8.25 -0.41 3.82e-15 Mean platelet volume; CRC cis rs72730918 0.564 rs6493507 chr15:51874119 C/T cg14296394 chr15:51910925 DMXL2 -0.44 -5.72 -0.3 2.42e-8 Intelligence (multi-trait analysis); CRC cis rs11227306 0.934 rs11227315 chr11:65590389 C/A cg26695010 chr11:65641043 EFEMP2 -0.48 -6.49 -0.34 3.11e-10 DNA methylation (variation); CRC cis rs6701037 0.681 rs13374887 chr1:175131962 A/T cg14847009 chr1:175162515 KIAA0040 0.27 5.87 0.31 1.09e-8 Alcohol dependence; CRC cis rs6951245 0.554 rs78999139 chr7:1138525 G/A cg04025307 chr7:1156635 C7orf50 0.67 8.49 0.42 7.21e-16 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs7584330 0.518 rs6715245 chr2:238445803 C/T cg08992911 chr2:238395768 MLPH 0.58 5.93 0.31 7.49e-9 Prostate cancer; CRC cis rs4509693 0.782 rs7897782 chr10:102495856 C/A cg23167259 chr10:102495509 NA -0.47 -6.52 -0.34 2.6e-10 Alzheimer's disease; CRC cis rs9322193 0.923 rs10872645 chr6:150063976 G/A cg13206674 chr6:150067644 NUP43 0.57 8.29 0.42 3.02e-15 Lung cancer; CRC cis rs4819052 0.851 rs13050359 chr21:46672671 T/G cg11663144 chr21:46675770 NA -0.82 -14.21 -0.62 4.78e-36 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs2243480 1.000 rs10807701 chr7:65724686 C/A cg18252515 chr7:66147081 NA 1.26 14.65 0.63 9.07e-38 Diabetic kidney disease; CRC trans rs1005277 0.579 rs116912400 chr10:38479207 G/T cg11292332 chr7:45801988 SEPT13 -0.38 -6.83 -0.35 4.14e-11 Extrinsic epigenetic age acceleration; CRC cis rs7904985 1.000 rs12358144 chr10:88114486 C/G cg07322936 chr10:88137208 NA -0.49 -6.57 -0.34 1.96e-10 Barrett's esophagus; CRC cis rs3087591 0.960 rs8080679 chr17:29602610 A/G cg24425628 chr17:29625626 OMG;NF1 0.88 17.44 0.69 1.06e-48 Hip circumference; CRC cis rs9584850 0.834 rs2031239 chr13:99111560 C/T cg07423050 chr13:99094983 FARP1 0.46 6.38 0.33 6.08e-10 Neuroticism; CRC cis rs6951245 0.938 rs113642700 chr7:1105654 C/T cg04025307 chr7:1156635 C7orf50 0.66 7.07 0.36 9.56e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs4665809 0.531 rs34081866 chr2:26475940 C/T cg08067268 chr2:26466485 HADHB;HADHA 0.64 8.39 0.42 1.46e-15 Gut microbiome composition (summer); CRC cis rs9649465 1.000 rs2109724 chr7:123325391 C/T cg03229431 chr7:123269106 ASB15 -0.36 -5.64 -0.3 3.7e-8 Migraine; CRC cis rs1018697 0.518 rs2250301 chr10:104548393 G/A cg04362960 chr10:104952993 NT5C2 -0.45 -5.62 -0.3 4.14e-8 Colorectal adenoma (advanced); CRC cis rs4690686 0.538 rs4690687 chr4:177259635 A/G cg17059388 chr4:177262070 NA -0.36 -5.61 -0.3 4.2e-8 Essential tremor; CRC cis rs10274279 1.000 rs10274279 chr7:157387441 C/T cg26886268 chr7:157387156 PTPRN2 0.45 5.69 0.3 2.76e-8 Myopia (pathological); CRC cis rs9311474 0.607 rs34005367 chr3:52558904 A/T cg15147215 chr3:52552868 STAB1 -0.66 -11.7 -0.54 1.12e-26 Electroencephalogram traits; CRC cis rs9443645 0.901 rs6454092 chr6:79701972 G/A cg11833968 chr6:79620685 NA -0.35 -5.99 -0.31 5.47e-9 Intelligence (multi-trait analysis); CRC cis rs12044355 0.858 rs3738401 chr1:231830295 G/A cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX 0.5 6.81 0.35 4.77e-11 Alzheimer's disease; CRC cis rs1707322 1.000 rs34694458 chr1:46332696 G/A cg03146154 chr1:46216737 IPP 0.49 6.84 0.35 3.79e-11 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs6748734 1.000 rs4344931 chr2:241818527 A/C cg07537917 chr2:241836409 C2orf54 -0.23 -6.48 -0.34 3.34e-10 Urinary metabolites; CRC cis rs9894429 0.716 rs7405578 chr17:79588306 C/A cg21984481 chr17:79567631 NPLOC4 -0.58 -10.97 -0.52 4.46e-24 Eye color traits; CRC cis rs910316 0.763 rs175057 chr14:75489632 C/T cg08847533 chr14:75593920 NEK9 -0.81 -13.59 -0.6 1.06e-33 Height; CRC trans rs3942852 0.703 rs11039513 chr11:48107204 C/T cg15704280 chr7:45808275 SEPT13 0.61 8.28 0.42 3.03e-15 Acute lymphoblastic leukemia (childhood); CRC cis rs951366 0.903 rs708723 chr1:205739266 C/T cg24503407 chr1:205819492 PM20D1 0.52 7.69 0.39 1.76e-13 Menarche (age at onset); CRC cis rs832540 0.669 rs832538 chr5:56200016 C/T cg24531977 chr5:56204891 C5orf35 -0.6 -9.11 -0.45 8.28e-18 Coronary artery disease; CRC cis rs8044868 0.548 rs12930702 chr16:72077000 C/G cg06172871 chr16:72088244 HP 0.44 6.27 0.33 1.13e-9 Body mass index (change over time) in cancer or chronic obstructive pulmonary disease;Body mass index (change over time) in cancer; CRC cis rs17213078 0.510 rs17032713 chr2:106886839 T/C cg16099169 chr2:106886729 NA -0.58 -10.62 -0.51 7.75e-23 Facial morphology (factor 23); CRC cis rs2243480 0.901 rs778687 chr7:65835819 G/A cg25985355 chr7:65971099 NA -0.53 -5.98 -0.31 5.75e-9 Diabetic kidney disease; CRC cis rs6952808 0.792 rs34269264 chr7:1948712 C/T cg02951883 chr7:2050386 MAD1L1 -0.69 -10.8 -0.51 1.8e-23 Bipolar disorder and schizophrenia; CRC cis rs4409675 0.576 rs7356 chr1:28218100 T/C cg11176159 chr1:28213800 NA 0.3 5.8 0.3 1.56e-8 Corneal astigmatism; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg01900965 chr4:2471727 RNF4 0.42 6.37 0.33 6.36e-10 Liver disease severity in Alagille syndrome; CRC cis rs853679 0.517 rs9380059 chr6:28132358 A/C cg03623178 chr6:28175578 NA 0.98 12.66 0.57 3.31e-30 Depression; CRC cis rs10193935 0.786 rs13399052 chr2:42385151 G/A cg27598129 chr2:42591480 NA -0.62 -7.17 -0.37 5.01e-12 Colonoscopy-negative controls vs population controls; CRC cis rs7945705 0.902 rs10769980 chr11:9014180 G/A cg12365402 chr11:9010492 NRIP3 0.53 8.88 0.44 4.47e-17 Hemoglobin concentration; CRC trans rs2243480 0.901 rs2900904 chr7:65204264 C/G cg10756647 chr7:56101905 PSPH 0.73 7.62 0.39 2.71e-13 Diabetic kidney disease; CRC cis rs4332037 0.539 rs34809719 chr7:2028968 G/T cg21155852 chr7:2048760 MAD1L1 -0.52 -6.98 -0.36 1.63e-11 Bipolar disorder; CRC cis rs12580194 0.593 rs66516917 chr12:55749131 T/G cg23425280 chr12:56401806 NA 0.45 5.66 0.3 3.26e-8 Cancer; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg07569756 chr17:48474564 LRRC59 0.48 6.75 0.35 6.86e-11 Response to antipsychotic treatment; CRC cis rs1448094 0.511 rs11610371 chr12:86163487 A/G cg00310523 chr12:86230176 RASSF9 0.37 6.03 0.32 4.38e-9 Major depressive disorder; CRC cis rs4332037 0.722 rs4719331 chr7:1914679 A/C cg25834613 chr7:1915315 MAD1L1 -0.5 -7.78 -0.39 9.28e-14 Bipolar disorder; CRC cis rs2075371 1.000 rs2598294 chr7:133991690 C/T cg11752832 chr7:134001865 SLC35B4 0.5 7.7 0.39 1.56e-13 Mean platelet volume; CRC cis rs8180040 0.966 rs12632132 chr3:47477019 C/T cg10298567 chr3:47292165 KIF9 -0.35 -5.79 -0.3 1.64e-8 Colorectal cancer; CRC cis rs10197940 0.624 rs6731486 chr2:152410732 C/T cg19508488 chr2:152266495 RIF1 -0.57 -8.68 -0.43 1.83e-16 Lung cancer; CRC cis rs6502050 0.835 rs12450189 chr17:80095128 A/C cg09264619 chr17:80180166 NA -0.34 -5.81 -0.3 1.5e-8 Life satisfaction; CRC cis rs7917772 0.503 rs7902306 chr10:104290462 C/T cg11453585 chr10:104263688 ACTR1A;SUFU 0.86 14.05 0.61 1.86e-35 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC cis rs782590 0.967 rs35504023 chr2:55806503 C/T cg18811423 chr2:55921094 PNPT1 -0.78 -14.46 -0.62 5.11e-37 Metabolic syndrome; CRC cis rs7493 1.000 rs7493 chr7:95034775 C/G cg01874867 chr7:94954059 PON1 0.5 6.33 0.33 7.94e-10 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs73200209 0.744 rs11612443 chr12:116518839 A/G cg01776926 chr12:116560359 MED13L -0.62 -7.28 -0.37 2.51e-12 Total body bone mineral density; CRC cis rs7705042 1.000 rs7705042 chr5:141492419 C/A cg08523384 chr5:141488047 NDFIP1 -0.34 -5.9 -0.31 9e-9 Asthma; CRC cis rs7618915 0.524 rs10433615 chr3:52638482 C/T cg11645453 chr3:52864694 ITIH4 0.35 6.13 0.32 2.58e-9 Bipolar disorder; CRC cis rs4665809 0.941 rs1434079 chr2:26284670 C/G cg26119090 chr2:26468346 HADHA;HADHB -0.61 -7.9 -0.4 4.35e-14 Gut microbiome composition (summer); CRC cis rs3751196 0.808 rs17034645 chr12:104218956 A/G cg02344784 chr12:104178138 NT5DC3 -0.67 -7.1 -0.36 7.56e-12 Sense of smell; CRC cis rs12900413 0.687 rs8035472 chr15:90313432 T/C cg24249390 chr15:90295951 MESP1 -0.58 -9.29 -0.46 2.14e-18 Coronary artery aneurysm in Kawasaki disease; CRC cis rs10504229 1.000 rs17805656 chr8:58180318 T/C cg22535103 chr8:58192502 C8orf71 -0.82 -12.27 -0.56 9.63e-29 Developmental language disorder (linguistic errors); CRC cis rs10771431 0.935 rs1988852 chr12:9372862 G/A cg08997352 chr12:9597637 DDX12 -0.41 -6.03 -0.32 4.51e-9 Breast size; CRC cis rs9322193 0.923 rs10872644 chr6:150062955 T/C cg13206674 chr6:150067644 NUP43 0.67 10.14 0.49 3.41e-21 Lung cancer; CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg00734800 chr3:50388182 TUSC4;CYB561D2 -0.54 -6.6 -0.34 1.65e-10 Diisocyanate-induced asthma; CRC cis rs2806561 0.929 rs6660880 chr1:23540302 T/C cg19743168 chr1:23544995 NA -0.37 -5.9 -0.31 8.96e-9 Height; CRC cis rs35110281 0.837 rs2838343 chr21:45078035 C/T cg01579765 chr21:45077557 HSF2BP -0.38 -7.2 -0.37 4.14e-12 Mean corpuscular volume; CRC cis rs1862618 0.671 rs2255726 chr5:56243128 T/C cg12311346 chr5:56204834 C5orf35 0.64 9.6 0.47 2.18e-19 Initial pursuit acceleration; CRC cis rs11105298 0.891 rs11105316 chr12:89925200 T/G cg08166232 chr12:89918718 WDR51B;GALNT4 -0.62 -7.62 -0.39 2.64e-13 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; CRC cis rs910316 0.687 rs175059 chr14:75490667 T/C cg11812906 chr14:75593930 NEK9 -0.58 -8.88 -0.44 4.34e-17 Height; CRC cis rs7107174 1.000 rs10899483 chr11:78061057 G/C cg02023728 chr11:77925099 USP35 0.48 8.15 0.41 7.74e-15 Testicular germ cell tumor; CRC cis rs59918340 0.764 rs3824234 chr8:142229370 T/C cg03316587 chr8:142245164 NA -0.38 -5.71 -0.3 2.46e-8 Immature fraction of reticulocytes; CRC cis rs6951245 0.554 rs4724294 chr7:1139695 G/A cg22907277 chr7:1156413 C7orf50 0.82 10.63 0.51 7.03e-23 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs8031584 0.678 rs798127 chr15:31117403 T/C cg14829155 chr15:31115871 NA 0.62 9.75 0.47 6.88e-20 Huntington's disease progression; CRC trans rs1814175 0.527 rs7110797 chr11:49644096 T/C cg11707556 chr5:10655725 ANKRD33B -0.44 -7.05 -0.36 1.05e-11 Height; CRC trans rs11098499 0.604 rs17051352 chr4:120581427 G/A cg25214090 chr10:38739885 LOC399744 0.58 8.67 0.43 2.01e-16 Corneal astigmatism; CRC cis rs2073499 1.000 rs79536844 chr3:50375066 C/T cg09545109 chr3:50388910 TUSC4;CYB561D2 0.67 5.85 0.31 1.16e-8 Schizophrenia; CRC cis rs12681287 0.640 rs7017706 chr8:87480890 C/T cg27223183 chr8:87520930 FAM82B -0.53 -7.52 -0.38 5.31e-13 Caudate activity during reward; CRC cis rs6840360 0.582 rs2709812 chr4:152335749 C/T cg09659197 chr4:152720779 NA -0.3 -5.77 -0.3 1.79e-8 Intelligence (multi-trait analysis); CRC cis rs12541335 0.639 rs13257108 chr8:22165043 T/C cg02463440 chr8:22132932 PIWIL2 0.5 8.66 0.43 2.23e-16 Hypertriglyceridemia; CRC cis rs9398803 0.865 rs9385401 chr6:126789472 C/T cg19875578 chr6:126661172 C6orf173 0.44 6.04 0.32 4.19e-9 Male-pattern baldness; CRC cis rs9372498 0.505 rs62424173 chr6:118780507 C/G cg07617317 chr6:118971624 C6orf204 0.52 6.4 0.33 5.29e-10 Diastolic blood pressure; CRC cis rs6662572 0.737 rs10890356 chr1:46317924 A/G cg03123370 chr1:45965343 CCDC163P;MMACHC -0.46 -5.9 -0.31 8.93e-9 Blood protein levels; CRC cis rs9322193 0.923 rs62439840 chr6:149995775 G/A cg05861140 chr6:150128134 PCMT1 -0.38 -5.94 -0.31 7.44e-9 Lung cancer; CRC cis rs10504229 0.593 rs10504216 chr8:57981470 G/A cg21724239 chr8:58056113 NA 0.75 9.0 0.44 1.86e-17 Developmental language disorder (linguistic errors); CRC cis rs78456975 1.000 rs13392535 chr2:1542634 G/T cg01028140 chr2:1542097 TPO -0.57 -5.81 -0.3 1.5e-8 Placebo response in major depressive disorder (% change in symptom score); CRC cis rs1448094 0.556 rs17279916 chr12:86170647 G/A cg18827107 chr12:86230957 RASSF9 -0.4 -6.11 -0.32 2.74e-9 Major depressive disorder; CRC cis rs929354 0.772 rs3802120 chr7:156977794 C/T cg16102536 chr7:156981717 UBE3C 0.4 6.76 0.35 6.39e-11 Body mass index; CRC cis rs72634258 0.836 rs9658012 chr1:7989022 C/T cg26816564 chr1:7831052 VAMP3 0.56 5.82 0.31 1.4e-8 Inflammatory bowel disease; CRC cis rs9916302 0.861 rs11078912 chr17:37671490 A/G cg03013999 chr17:37608204 MED1 0.43 6.49 0.34 3.21e-10 Glomerular filtration rate (creatinine); CRC trans rs11098499 0.739 rs9884728 chr4:120127079 C/T cg25214090 chr10:38739885 LOC399744 -0.43 -6.84 -0.35 3.96e-11 Corneal astigmatism; CRC cis rs2880765 0.710 rs11630457 chr15:86004801 T/C cg17133734 chr15:86042851 AKAP13 0.41 6.47 0.34 3.48e-10 Coronary artery disease; CRC cis rs875971 0.545 rs316306 chr7:65618674 G/A cg11764359 chr7:65958608 NA -0.47 -6.0 -0.31 5.22e-9 Aortic root size; CRC trans rs2018683 0.707 rs10279870 chr7:28968935 A/G cg19402173 chr7:128379420 CALU -0.42 -6.18 -0.32 1.93e-9 Response to irinotecan and platinum-based chemotherapy in non-small-cell lung cancer; CRC cis rs9733 0.503 rs7556451 chr1:150913142 A/G cg17724175 chr1:150552817 MCL1 0.4 6.14 0.32 2.37e-9 Tonsillectomy; CRC cis rs17539620 0.534 rs6557363 chr6:154827813 A/G cg20019720 chr6:154832845 CNKSR3 0.55 10.47 0.5 2.45e-22 Lipoprotein (a) levels; CRC cis rs7666738 0.791 rs2903151 chr4:99027218 T/C cg17366294 chr4:99064904 C4orf37 0.44 7.48 0.38 6.96e-13 Colonoscopy-negative controls vs population controls; CRC cis rs1153858 1.000 rs61365925 chr15:45650311 T/C cg21132104 chr15:45694354 SPATA5L1 0.58 8.6 0.43 3.38e-16 Homoarginine levels; CRC trans rs75804782 0.641 rs2340870 chr2:239356026 C/T cg01134436 chr17:81009848 B3GNTL1 0.72 6.76 0.35 6.27e-11 Morning vs. evening chronotype;Chronotype; CRC cis rs10504229 0.683 rs72649192 chr8:58110490 T/C cg02290350 chr8:58132656 NA -0.6 -7.25 -0.37 2.97e-12 Developmental language disorder (linguistic errors); CRC cis rs72634258 0.786 rs7524424 chr1:8173369 A/G cg26816564 chr1:7831052 VAMP3 0.46 5.75 0.3 2e-8 Inflammatory bowel disease; CRC trans rs10411161 0.702 rs11878586 chr19:52388576 A/G cg22319618 chr22:45562946 NUP50 -0.65 -7.22 -0.37 3.63e-12 Breast cancer; CRC cis rs6076065 0.723 rs1936013 chr20:23363989 A/G cg11657817 chr20:23433608 CST11 0.47 6.85 0.35 3.74e-11 Facial morphology (factor 15, philtrum width); CRC cis rs2777491 0.872 rs61037359 chr15:41585926 T/C cg18705301 chr15:41695430 NDUFAF1 -0.7 -11.57 -0.54 3.29e-26 Ulcerative colitis; CRC cis rs78456975 0.527 rs11884165 chr2:1561052 A/G cg26248373 chr2:1572462 NA -0.8 -10.96 -0.52 4.81e-24 Placebo response in major depressive disorder (% change in symptom score); CRC cis rs875971 0.545 rs2173571 chr7:65770379 G/A cg05627663 chr7:65219948 SNORA22;CCT6P1 0.61 7.93 0.4 3.53e-14 Aortic root size; CRC cis rs6951245 1.000 rs79327308 chr7:1108141 A/C cg18402987 chr7:1209562 NA 0.67 7.17 0.37 4.89e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs780096 0.526 rs13472 chr2:27600239 G/A cg17158414 chr2:27665306 KRTCAP3 -0.29 -6.06 -0.32 3.64e-9 Total body bone mineral density; CRC cis rs1448094 0.648 rs10863093 chr12:86285792 T/G cg18827107 chr12:86230957 RASSF9 -0.45 -7.25 -0.37 3.07e-12 Major depressive disorder; CRC cis rs7827545 1.000 rs4909911 chr8:135565255 G/A cg17885191 chr8:135476712 NA 0.54 7.37 0.38 1.41e-12 Hypertension (SNP x SNP interaction); CRC cis rs597539 0.652 rs627731 chr11:68698663 A/C cg21963583 chr11:68658836 MRPL21 0.59 10.44 0.5 3.22e-22 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs17681684 0.565 rs12150167 chr17:9764244 C/A cg26853458 chr17:9805074 RCVRN 0.53 9.4 0.46 9.35e-19 GIP levels in response to oral glucose tolerance test (fasting); CRC trans rs2303319 0.504 rs62189043 chr2:162608466 A/T cg22902534 chr3:183892754 AP2M1 -0.7 -6.1 -0.32 2.96e-9 Cognitive function; CRC trans rs11148252 0.538 rs2274202 chr13:52722798 C/A cg18335740 chr13:41363409 SLC25A15 0.54 8.21 0.41 5.03e-15 Lewy body disease; CRC cis rs597539 0.652 rs613128 chr11:68638058 G/T cg06112835 chr11:68658793 MRPL21 0.43 6.88 0.35 3.11e-11 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs4891159 0.756 rs55763305 chr18:74161249 G/C cg24786174 chr18:74118243 ZNF516 -0.8 -13.3 -0.59 1.41e-32 Longevity; CRC cis rs3820068 0.603 rs6429768 chr1:15963531 G/A cg13390004 chr1:15929781 NA 0.5 7.07 0.36 9.19e-12 Systolic blood pressure; CRC trans rs2727020 0.930 rs1164686 chr11:49291822 C/T cg15704280 chr7:45808275 SEPT13 0.72 10.13 0.49 3.57e-21 Coronary artery disease; CRC cis rs875971 0.898 rs6977501 chr7:65693342 T/C cg12463550 chr7:65579703 CRCP -0.51 -7.29 -0.37 2.26e-12 Aortic root size; CRC cis rs10924970 0.625 rs3806394 chr1:235489850 C/T cg09010748 chr1:235293032 TOMM20 -0.41 -5.79 -0.3 1.64e-8 Asthma; CRC cis rs6502050 0.805 rs7406682 chr17:80084368 C/T cg19223190 chr17:80058835 NA -0.39 -6.24 -0.33 1.31e-9 Life satisfaction; CRC cis rs1552244 0.554 rs3846169 chr3:9997054 A/G cg18598329 chr3:10140678 FANCD2;C3orf24 0.55 8.26 0.41 3.57e-15 Alzheimer's disease; CRC trans rs1728785 0.818 rs1728772 chr16:68584526 C/T cg04657470 chr2:198365150 HSPE1;HSPD1 0.58 7.07 0.36 9.08e-12 Ulcerative colitis; CRC cis rs477692 0.905 rs563859 chr10:131417586 T/C cg26102564 chr10:131424627 MGMT 0.39 5.74 0.3 2.2e-8 Response to temozolomide; CRC cis rs3789045 0.560 rs4626956 chr1:204407298 T/C cg17419461 chr1:204415978 PIK3C2B -0.81 -10.84 -0.51 1.33e-23 Educational attainment (college completion); CRC trans rs7615952 0.558 rs17334039 chr3:125540308 A/G cg07211511 chr3:129823064 LOC729375 -0.91 -13.23 -0.59 2.44e-32 Blood pressure (smoking interaction); CRC cis rs7274811 0.711 rs373618 chr20:31992639 C/A cg03904042 chr20:32255491 NECAB3;C20orf134 0.41 5.74 0.3 2.13e-8 Height; CRC cis rs6582630 0.563 rs923281 chr12:38590241 G/A cg26384229 chr12:38710491 ALG10B -0.52 -7.52 -0.38 5.15e-13 Drug-induced liver injury (flucloxacillin); CRC cis rs8072100 0.754 rs8081717 chr17:45653921 T/A cg25173405 chr17:45401733 C17orf57 0.46 7.23 0.37 3.49e-12 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs427943 0.750 rs8126717 chr21:46609110 A/C cg19498844 chr21:46707878 POFUT2;LOC642852 0.45 6.0 0.31 5.1e-9 Body mass index; CRC cis rs2730260 0.734 rs3793217 chr7:158848821 C/T cg02254261 chr7:158964346 NA 0.49 5.72 0.3 2.39e-8 Myopia (pathological); CRC cis rs10986311 0.802 rs1323761 chr9:127116942 C/T cg14243010 chr9:127117328 LOC100129034;PSMB7 0.4 6.03 0.32 4.52e-9 Vitiligo; CRC cis rs853679 0.517 rs4713143 chr6:28106759 A/C cg02631126 chr6:28058918 ZSCAN12L1 0.29 5.89 0.31 9.41e-9 Depression; CRC cis rs1005277 0.579 rs1740737 chr10:38499365 G/T cg25517755 chr10:38738941 LOC399744 -0.43 -6.16 -0.32 2.14e-9 Extrinsic epigenetic age acceleration; CRC trans rs3733585 0.699 rs6815001 chr4:9958662 G/C cg26043149 chr18:55253948 FECH -0.5 -7.62 -0.39 2.81e-13 Cleft plate (environmental tobacco smoke interaction); CRC cis rs2795502 1.000 rs3121279 chr10:43378449 T/A cg20628663 chr10:43360327 NA 0.57 9.3 0.46 2.01e-18 Blood protein levels; CRC cis rs2354432 0.607 rs7516430 chr1:146767062 A/G cg25205988 chr1:146714368 CHD1L -1.14 -12.49 -0.57 1.4e-29 Mitochondrial DNA levels; CRC cis rs1448094 0.791 rs10863114 chr12:86332325 T/C cg18827107 chr12:86230957 RASSF9 -0.42 -6.62 -0.34 1.43e-10 Major depressive disorder; CRC cis rs7542091 0.704 rs9429825 chr1:210052133 C/G cg22029157 chr1:209979665 IRF6 0.5 7.89 0.4 4.61e-14 Monobrow; CRC cis rs2985684 1.000 rs1952012 chr14:50098896 T/A cg04989706 chr14:50066350 PPIL5 -0.5 -7.08 -0.36 9.01e-12 Carotid intima media thickness; CRC cis rs17711722 0.522 rs62469933 chr7:65265639 G/A cg05627663 chr7:65219948 SNORA22;CCT6P1 0.63 9.85 0.48 3.26e-20 Calcium levels; CRC cis rs72634258 0.945 rs225132 chr1:8095500 A/C cg00042356 chr1:8021962 PARK7 0.55 6.77 0.35 5.99e-11 Inflammatory bowel disease; CRC cis rs2282802 0.685 rs6867870 chr5:139641896 C/A cg26211634 chr5:139558579 C5orf32 0.41 6.94 0.36 2.15e-11 Intelligence (multi-trait analysis); CRC trans rs2243480 1.000 rs160643 chr7:65558222 C/T cg10756647 chr7:56101905 PSPH 0.57 6.59 0.34 1.78e-10 Diabetic kidney disease; CRC cis rs250677 0.687 rs250663 chr5:148453117 T/C cg23229984 chr5:148520753 ABLIM3 0.5 7.04 0.36 1.11e-11 Breast cancer; CRC cis rs877282 0.898 rs11253349 chr10:765897 C/G cg17470449 chr10:769945 NA 0.64 8.08 0.41 1.28e-14 Uric acid levels; CRC cis rs561341 0.830 rs2301765 chr17:30202056 T/A cg19193384 chr17:30244184 NA 0.47 5.81 0.31 1.47e-8 Hip circumference adjusted for BMI; CRC cis rs9814567 1.000 rs9863786 chr3:134247203 C/G cg06541857 chr3:134203789 ANAPC13;CEP63 -0.4 -6.12 -0.32 2.73e-9 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs1799949 1.000 rs12951869 chr17:41187567 T/G cg25072359 chr17:41440525 NA 0.47 6.92 0.36 2.32e-11 Menopause (age at onset); CRC cis rs11212617 0.967 rs227068 chr11:108210109 A/G cg12106634 chr11:108092400 ATM;NPAT 0.43 6.34 0.33 7.65e-10 Response to metformin in type 2 diabetes (glycemic); CRC cis rs3751196 0.901 rs116516318 chr12:104177773 C/T cg02344784 chr12:104178138 NT5DC3 0.72 7.65 0.39 2.26e-13 Sense of smell; CRC cis rs1862618 0.853 rs832568 chr5:56153776 G/A cg24531977 chr5:56204891 C5orf35 -0.83 -10.99 -0.52 3.94e-24 Initial pursuit acceleration; CRC cis rs2213920 0.619 rs7870511 chr9:118196904 A/G cg13918206 chr9:118159781 DEC1 0.62 5.96 0.31 6.67e-9 Docetaxel-induced peripheral neuropathy in metastatic castrate-resistant prostate cancer; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg01283712 chr14:106919294 NA -0.35 -5.97 -0.31 5.99e-9 Liver disease severity in Alagille syndrome; CRC cis rs35883536 0.609 rs1855631 chr1:101040010 C/T cg06223162 chr1:101003688 GPR88 -0.34 -6.29 -0.33 1.01e-9 Monocyte count; CRC cis rs1552244 1.000 rs67134728 chr3:10151431 G/C cg16606324 chr3:10149918 C3orf24 0.72 9.56 0.47 2.94e-19 Alzheimer's disease; CRC cis rs6543140 0.964 rs13393175 chr2:103078849 T/G cg03938978 chr2:103052716 IL18RAP 0.41 6.53 0.34 2.51e-10 Blood protein levels; CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg18654971 chr5:54469363 MIR449C;CDC20B -0.51 -6.17 -0.32 2e-9 Diisocyanate-induced asthma; CRC cis rs561341 1.000 rs55959993 chr17:30254771 C/G cg23018236 chr17:30244563 NA -0.66 -7.89 -0.4 4.54e-14 Hip circumference adjusted for BMI; CRC cis rs514406 0.893 rs499195 chr1:53344907 C/T cg08859206 chr1:53392774 SCP2 -0.48 -7.49 -0.38 6.6e-13 Monocyte count; CRC cis rs752010 0.806 rs1109255 chr1:42091708 C/T cg06885757 chr1:42089581 HIVEP3 0.45 8.16 0.41 7.24e-15 Lupus nephritis in systemic lupus erythematosus; CRC cis rs4319547 0.698 rs4039670 chr12:122822655 A/G cg05707623 chr12:122985044 ZCCHC8 -0.68 -8.34 -0.42 2.11e-15 Body mass index; CRC cis rs1129187 0.902 rs6907751 chr6:42944850 C/T cg27588902 chr6:42928151 GNMT -0.4 -7.31 -0.37 2.05e-12 Alzheimer's disease in APOE e4+ carriers; CRC trans rs7618501 0.633 rs2353579 chr3:50027774 C/T cg21659725 chr3:3221576 CRBN 0.54 8.48 0.42 7.53e-16 Intelligence (multi-trait analysis); CRC cis rs1552244 0.748 rs113890152 chr3:10085986 A/G cg16606324 chr3:10149918 C3orf24 0.73 9.65 0.47 1.47e-19 Alzheimer's disease; CRC cis rs35110281 0.807 rs9976441 chr21:45046591 G/A cg01579765 chr21:45077557 HSF2BP -0.36 -6.77 -0.35 6.1e-11 Mean corpuscular volume; CRC cis rs477692 0.618 rs7080419 chr10:131455235 A/G cg05714579 chr10:131428358 MGMT 0.46 6.43 0.33 4.57e-10 Response to temozolomide; CRC cis rs2976388 0.609 rs2585148 chr8:143796193 C/G cg15511327 chr8:143859410 LYNX1 0.41 7.41 0.38 1.07e-12 Urinary tract infection frequency; CRC cis rs8060686 0.641 rs7204974 chr16:68033539 G/A cg07125278 chr16:67683757 RLTPR -0.46 -5.63 -0.3 3.91e-8 HDL cholesterol;Metabolic syndrome; CRC cis rs4731207 0.592 rs6967988 chr7:124570472 T/A cg23710748 chr7:124431027 NA -0.4 -6.3 -0.33 9.64e-10 Cutaneous malignant melanoma; CRC cis rs7647973 0.731 rs9831648 chr3:49214303 G/T cg20833759 chr3:49053208 WDR6;DALRD3 0.45 6.59 0.34 1.7e-10 Menarche (age at onset); CRC cis rs17818399 0.620 rs3087822 chr2:46852033 C/T cg26688816 chr2:46740690 ATP6V1E2 0.4 5.95 0.31 6.78e-9 Height; CRC cis rs2742417 0.624 rs2673029 chr3:45758867 A/G cg04837898 chr3:45731254 SACM1L -0.49 -7.87 -0.4 5.1e-14 Response to anti-depressant treatment in major depressive disorder; CRC cis rs4819052 0.851 rs2255774 chr21:46683851 A/T cg11663144 chr21:46675770 NA -0.68 -11.02 -0.52 3.03e-24 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg24787592 chr19:13273612 NA 0.43 6.15 0.32 2.2e-9 Response to antipsychotic treatment; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg03077572 chr17:79869459 PCYT2 0.48 6.63 0.34 1.35e-10 Anxiety disorder; CRC cis rs1552244 0.935 rs7652190 chr3:10105150 G/A cg00166722 chr3:10149974 C3orf24 0.71 9.42 0.46 8.32e-19 Alzheimer's disease; CRC cis rs2115630 0.645 rs4842978 chr15:85197253 T/C cg12501888 chr15:85177176 SCAND2 -0.45 -7.57 -0.39 3.68e-13 P wave terminal force; CRC cis rs6951245 0.935 rs78573577 chr7:1089087 C/A cg03188948 chr7:1209495 NA 0.64 6.46 0.34 3.71e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC trans rs7553035 1.000 rs11800588 chr1:211689466 A/C cg04286297 chr15:83655119 FAM103A1 -0.66 -6.04 -0.32 4.08e-9 Retinopathy in non-diabetics; CRC cis rs60871478 1.000 rs4374882 chr7:821798 C/T cg04727924 chr7:799746 HEATR2 -0.42 -6.52 -0.34 2.59e-10 Cerebrospinal P-tau181p levels; CRC cis rs10504229 0.683 rs949856 chr8:58144496 G/A cg21724239 chr8:58056113 NA 0.48 6.62 0.34 1.45e-10 Developmental language disorder (linguistic errors); CRC cis rs2032447 0.839 rs9356995 chr6:25996673 G/A cg12588279 chr6:26043732 HIST1H2BB 0.47 6.9 0.36 2.7e-11 Intelligence (multi-trait analysis); CRC trans rs11098499 0.644 rs6855918 chr4:120546299 C/T cg25214090 chr10:38739885 LOC399744 0.59 9.25 0.45 2.85e-18 Corneal astigmatism; CRC cis rs6500602 0.702 rs17761816 chr16:4548832 C/G cg14951292 chr16:4525986 HMOX2;NMRAL1 0.56 8.59 0.43 3.65e-16 Schizophrenia; CRC trans rs2553218 0.690 rs8032415 chr15:54851945 A/G cg17227014 chr4:6642450 MRFAP1 0.46 6.08 0.32 3.29e-9 Immune response to smallpox vaccine (IL-6); CRC cis rs35883536 0.647 rs10875316 chr1:101044150 G/A cg06223162 chr1:101003688 GPR88 -0.36 -6.66 -0.34 1.12e-10 Monocyte count; CRC cis rs668210 0.793 rs1786172 chr11:65770658 A/G cg02202077 chr11:65769826 EIF1AD;BANF1 0.51 6.81 0.35 4.6e-11 Cerebrospinal fluid biomarker levels; CRC cis rs709400 0.663 rs7152202 chr14:103886757 A/G cg12935359 chr14:103987150 CKB -0.49 -7.99 -0.4 2.29e-14 Body mass index; CRC cis rs3008870 1.000 rs2985825 chr1:67412822 T/G cg08660285 chr1:67390436 MIER1;WDR78 1.01 14.84 0.63 1.71e-38 Lymphocyte percentage of white cells; CRC cis rs703842 0.560 rs11533604 chr12:58047713 G/A cg00677455 chr12:58241039 CTDSP2 0.53 6.35 0.33 7.1e-10 Multiple sclerosis; CRC cis rs6700896 0.931 rs12042779 chr1:66133950 T/C cg04111102 chr1:66153794 NA 0.35 6.1 0.32 3.03e-9 C-reactive protein;Mean corpuscular volume;Mean corpuscular hemoglobin; CRC cis rs6963495 0.818 rs818621 chr7:105173029 T/C cg19920283 chr7:105172520 RINT1 0.54 6.66 0.34 1.12e-10 Bipolar disorder (body mass index interaction); CRC cis rs7937682 0.855 rs571462 chr11:111487106 C/G cg19812747 chr11:111475976 SIK2 -0.59 -10.14 -0.49 3.31e-21 Primary sclerosing cholangitis; CRC cis rs317689 0.690 rs570256 chr12:69662929 A/T cg20891283 chr12:69753455 YEATS4 0.45 5.8 0.3 1.53e-8 Response to diuretic therapy; CRC cis rs17539620 0.534 rs7768635 chr6:154827861 C/T cg20019720 chr6:154832845 CNKSR3 0.52 10.12 0.49 4.03e-21 Lipoprotein (a) levels; CRC cis rs11098499 0.865 rs28634456 chr4:120375778 A/G cg24375607 chr4:120327624 NA 0.52 7.86 0.4 5.65e-14 Corneal astigmatism; CRC cis rs4713118 0.696 rs2394002 chr6:27748015 G/A cg02683197 chr6:28174875 NA 0.66 8.52 0.43 5.91e-16 Parkinson's disease; CRC cis rs1568889 0.838 rs3812738 chr11:28129982 C/A cg06544937 chr11:28130018 METT5D1;KIF18A 0.92 15.41 0.65 1.01e-40 Bipolar disorder; CRC cis rs9381040 0.610 rs2268191 chr6:41027653 G/C cg25110423 chr6:41068646 NFYA;LOC221442 -0.38 -5.82 -0.31 1.43e-8 Alzheimer's disease (late onset); CRC cis rs7224737 1.000 rs11079034 chr17:40288890 G/A cg02228675 chr17:40259724 DHX58 -0.48 -6.87 -0.35 3.19e-11 Fibrinogen levels; CRC trans rs7705042 0.761 rs10062349 chr5:141509597 G/A cg03701575 chr16:83960119 NA 0.34 5.97 0.31 6.14e-9 Asthma; CRC cis rs477895 1.000 rs34292685 chr11:64049021 C/T cg19465662 chr11:63993652 NUDT22;TRPT1 0.65 6.66 0.34 1.13e-10 Mean platelet volume; CRC cis rs6761276 0.649 rs10169599 chr2:113838652 A/G cg09040174 chr2:113837401 NA -0.57 -8.82 -0.44 6.76e-17 Protein quantitative trait loci; CRC cis rs7224685 0.501 rs781853 chr17:3953083 T/C cg05562828 chr17:3906858 NA 0.66 11.83 0.55 3.85e-27 Type 2 diabetes; CRC cis rs929596 0.531 rs2741019 chr2:234510688 C/G cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.44 -5.82 -0.31 1.41e-8 Total bilirubin levels in HIV-1 infection; CRC cis rs6754459 0.694 rs4404281 chr2:3706055 C/T cg25251562 chr2:3704773 ALLC -0.45 -6.65 -0.34 1.21e-10 Response to inhaled corticosteroid treatment in asthma (change in FEV1); CRC cis rs1552244 0.882 rs9312044 chr3:10037481 T/C cg00166722 chr3:10149974 C3orf24 0.57 7.8 0.4 8.13e-14 Alzheimer's disease; CRC cis rs13382862 0.895 rs13385499 chr2:20882413 A/G cg14780466 chr2:20870812 GDF7 -0.37 -7.28 -0.37 2.44e-12 Abdominal aortic aneurysm; CRC cis rs10078 0.528 rs2434697 chr5:466811 T/C cg08916839 chr5:415575 AHRR 0.83 8.44 0.42 1e-15 Fat distribution (HIV); CRC trans rs561341 1.000 rs554078 chr17:30330109 A/C cg20587970 chr11:113659929 NA -1.42 -20.04 -0.74 5.73e-59 Hip circumference adjusted for BMI; CRC cis rs13108904 0.935 rs4246685 chr4:1279727 T/C cg21620606 chr4:1342894 KIAA1530 0.36 5.91 0.31 8.57e-9 Obesity-related traits; CRC cis rs7591163 1.000 rs4973380 chr2:228725402 T/A cg00063174 chr2:228736253 WDR69 -0.48 -6.38 -0.33 5.97e-10 Blood pressure; CRC cis rs910316 0.967 rs4903285 chr14:75609268 A/T cg11812906 chr14:75593930 NEK9 0.64 10.4 0.5 4.22e-22 Height; CRC cis rs9287719 0.615 rs12613769 chr2:10742290 C/T cg00105475 chr2:10696890 NA 0.48 7.3 0.37 2.14e-12 Prostate cancer; CRC cis rs75920871 0.528 rs11216244 chr11:116912730 C/T cg20608306 chr11:116969690 SIK3 -0.34 -6.38 -0.33 6.09e-10 Subjective well-being; CRC cis rs12530845 0.623 rs76485854 chr7:135352668 T/C cg23117316 chr7:135346802 PL-5283 -0.52 -6.68 -0.35 1.01e-10 Red blood cell traits; CRC cis rs11785693 0.862 rs62491171 chr8:4987177 G/A cg26367366 chr8:4980734 NA 0.81 9.91 0.48 1.92e-20 Neuroticism (multi-trait analysis);Neuroticism; CRC cis rs1387259 0.570 rs12368659 chr12:48562299 C/A cg00601486 chr12:48723148 H1FNT 0.35 6.78 0.35 5.51e-11 Obstructive sleep apnea trait (apnea hypopnea index); CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg03175635 chr2:203736521 ICA1L 0.45 6.28 0.33 1.04e-9 Anxiety disorder; CRC cis rs473651 0.506 rs561264 chr2:239329979 G/T cg18131467 chr2:239335373 ASB1 0.78 11.92 0.55 1.77e-27 Multiple system atrophy; CRC cis rs1129187 0.755 rs2274517 chr6:42932715 A/G cg09436375 chr6:42928200 GNMT 0.34 6.4 0.33 5.31e-10 Alzheimer's disease in APOE e4+ carriers; CRC cis rs2839186 0.708 rs17183123 chr21:47671961 G/C cg13126279 chr21:47581558 C21orf56 -0.46 -7.36 -0.38 1.51e-12 Testicular germ cell tumor; CRC cis rs7591163 1.000 rs1039665 chr2:228717392 A/G cg23807890 chr2:228736357 WDR69 -0.51 -7.0 -0.36 1.44e-11 Blood pressure; CRC cis rs11969893 0.737 rs6930051 chr6:101406108 A/G cg12253828 chr6:101329408 ASCC3 0.8 6.54 0.34 2.31e-10 Economic and political preferences (immigration/crime); CRC cis rs9322193 0.923 rs10782317 chr6:150075047 C/T cg13206674 chr6:150067644 NUP43 -0.68 -10.28 -0.49 1.13e-21 Lung cancer; CRC cis rs644799 0.710 rs10831433 chr11:95519787 C/T cg25478527 chr11:95522999 CEP57;FAM76B 0.5 7.61 0.39 2.87e-13 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs1552244 1.000 rs6442147 chr3:10078247 A/G cg02579736 chr3:10068473 FANCD2;CIDECP 0.95 12.93 0.58 3.26e-31 Alzheimer's disease; CRC cis rs6735179 0.729 rs2382560 chr2:1762828 A/G cg19300414 chr2:1746591 PXDN 0.34 6.18 0.32 1.86e-9 Response to antipsychotic treatment; CRC cis rs1862618 0.671 rs2591961 chr5:56238597 A/G cg24531977 chr5:56204891 C5orf35 0.65 10.3 0.49 9.45e-22 Initial pursuit acceleration; CRC cis rs6860806 0.507 rs274572 chr5:131710917 T/G cg04518342 chr5:131593106 PDLIM4 -0.43 -7.03 -0.36 1.16e-11 Breast cancer; CRC cis rs7412746 0.611 rs11204748 chr1:150927369 G/T cg17724175 chr1:150552817 MCL1 0.4 6.14 0.32 2.37e-9 Melanoma; CRC cis rs7833790 0.963 rs72686466 chr8:82758928 G/T cg17211192 chr8:82754475 SNX16 0.56 6.79 0.35 5.1e-11 Diastolic blood pressure; CRC trans rs9291683 0.609 rs13141233 chr4:10028729 T/C cg26043149 chr18:55253948 FECH 0.53 8.11 0.41 9.94e-15 Bone mineral density; CRC cis rs763121 0.853 rs1569716 chr22:38998519 C/A cg06544989 chr22:39130855 UNC84B 0.45 7.25 0.37 3.03e-12 Menopause (age at onset); CRC cis rs4731207 0.596 rs10252072 chr7:124578636 G/A cg23710748 chr7:124431027 NA -0.39 -6.12 -0.32 2.67e-9 Cutaneous malignant melanoma; CRC cis rs992157 1.000 rs992157 chr2:219154781 A/G cg04731861 chr2:219085781 ARPC2 0.26 5.69 0.3 2.82e-8 Colorectal cancer; CRC cis rs477895 0.653 rs7939784 chr11:63910153 C/T cg18225595 chr11:63971243 STIP1 0.57 7.54 0.38 4.59e-13 Mean platelet volume; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg19541444 chr11:73472205 RAB6A 0.43 6.01 0.31 5.02e-9 Anxiety disorder; CRC cis rs1552244 0.882 rs67631672 chr3:10004768 G/A cg02579736 chr3:10068473 FANCD2;CIDECP 0.94 12.18 0.56 2e-28 Alzheimer's disease; CRC cis rs1348850 0.554 rs7595576 chr2:178371921 C/T cg27490568 chr2:178487706 NA 0.62 7.61 0.39 2.95e-13 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs1799949 1.000 rs9646417 chr17:41424253 G/A cg25072359 chr17:41440525 NA 0.44 6.4 0.33 5.49e-10 Menopause (age at onset); CRC cis rs1008375 1.000 rs7697889 chr4:17617961 G/T cg16339924 chr4:17578868 LAP3 0.54 7.36 0.38 1.5e-12 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs739401 0.611 rs3782069 chr11:3033275 G/A cg08508325 chr11:3079039 CARS -0.5 -9.07 -0.45 1.1e-17 Longevity; CRC cis rs9322193 0.962 rs12175575 chr6:150084487 G/A cg13206674 chr6:150067644 NUP43 0.57 8.19 0.41 5.85e-15 Lung cancer; CRC cis rs965469 1.000 rs6051792 chr20:3343519 T/C cg25506879 chr20:3388711 C20orf194 -0.39 -5.76 -0.3 1.91e-8 IFN-related cytopenia; CRC cis rs13098911 0.540 rs9877748 chr3:46111081 A/G cg12691230 chr3:46064611 XCR1 -0.54 -6.14 -0.32 2.34e-9 Celiac disease; CRC cis rs4481887 0.508 rs4474292 chr1:248396646 G/A cg00666640 chr1:248458726 OR2T12 0.36 6.25 0.33 1.27e-9 Common traits (Other); CRC cis rs473651 0.904 rs62196716 chr2:239356977 C/G cg08773314 chr2:239334832 ASB1 0.38 8.71 0.43 1.51e-16 Multiple system atrophy; CRC cis rs375066 0.935 rs429027 chr19:44395489 G/A cg11993925 chr19:44307056 LYPD5 0.37 5.76 0.3 1.94e-8 Breast cancer; CRC cis rs3760982 1.000 rs10421887 chr19:44294849 C/T cg11993925 chr19:44307056 LYPD5 -0.44 -7.18 -0.37 4.54e-12 Breast cancer (estrogen-receptor negative);Breast cancer; CRC cis rs7843479 0.582 rs13439690 chr8:21778082 T/C cg16476235 chr8:21771668 DOK2 0.39 6.42 0.33 4.88e-10 Mean corpuscular volume; CRC cis rs611744 0.647 rs615233 chr8:109254262 C/T cg18478394 chr8:109455254 TTC35 0.39 6.03 0.32 4.51e-9 Dupuytren's disease; CRC cis rs929354 0.713 rs3802129 chr7:156965297 G/A cg16102536 chr7:156981717 UBE3C 0.4 6.69 0.35 9.74e-11 Body mass index; CRC cis rs4332037 0.508 rs60238952 chr7:1914350 A/G cg23422044 chr7:1970798 MAD1L1 -0.46 -6.18 -0.32 1.91e-9 Bipolar disorder; CRC cis rs12701220 0.655 rs6463317 chr7:1159243 G/A cg26240231 chr7:1148101 C7orf50 -0.42 -6.52 -0.34 2.6200000000000003e-10 Bronchopulmonary dysplasia; CRC trans rs7267979 0.844 rs1555330 chr20:25232097 A/C cg17903999 chr18:56338584 MALT1 -0.41 -6.48 -0.34 3.29e-10 Liver enzyme levels (alkaline phosphatase); CRC trans rs7618501 1.000 rs35261599 chr3:49773236 G/A cg21665057 chr3:196295764 WDR53;FBXO45 -0.86 -16.08 -0.66 2.34e-43 Intelligence (multi-trait analysis); CRC cis rs936229 0.749 rs4886633 chr15:75178207 G/A cg10253484 chr15:75165896 SCAMP2 -0.46 -6.81 -0.35 4.71e-11 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); CRC cis rs6831352 0.918 rs13110176 chr4:100062430 C/T cg12011299 chr4:100065546 ADH4 0.51 9.63 0.47 1.7e-19 Alcohol dependence; CRC cis rs6951245 0.748 rs79658522 chr7:1095877 A/G cg24642844 chr7:1081250 C7orf50 -0.78 -9.44 -0.46 7.23e-19 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs7568498 0.517 rs197261 chr2:161904823 A/G cg22496339 chr2:162101262 NA -0.57 -7.98 -0.4 2.51e-14 Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 3 peripheral neuropathy); CRC cis rs644799 0.622 rs1255167 chr11:95500213 C/T cg03916912 chr11:95522834 CEP57;FAM76B 0.72 12.21 0.56 1.51e-28 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs3785574 0.962 rs2584630 chr17:61887561 T/A cg06873352 chr17:61820015 STRADA 0.5 7.83 0.4 6.98e-14 Height; CRC cis rs6881634 0.768 rs4704495 chr5:77624910 C/T cg11446398 chr5:77624930 NA 0.51 8.83 0.44 6.15e-17 Hippocampal atrophy; CRC cis rs644799 0.635 rs10831428 chr11:95508404 C/A cg25478527 chr11:95522999 CEP57;FAM76B 0.5 7.57 0.38 3.89e-13 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs7799006 0.755 rs2256545 chr7:2291943 G/A cg08027265 chr7:2291960 NA -0.46 -7.6 -0.39 3.11e-13 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs2836974 0.932 rs2836955 chr21:40619887 G/A cg11644478 chr21:40555479 PSMG1 0.71 10.21 0.49 1.9e-21 Cognitive function; CRC cis rs1448094 0.511 rs10863080 chr12:86153149 C/T cg02569458 chr12:86230093 RASSF9 -0.48 -7.92 -0.4 3.61e-14 Major depressive disorder; CRC cis rs11098499 0.754 rs12506487 chr4:120271361 T/G cg09307838 chr4:120376055 NA 0.6 9.3 0.46 1.95e-18 Corneal astigmatism; CRC cis rs8180040 0.715 rs6772670 chr3:47191349 G/A cg10298567 chr3:47292165 KIF9 -0.36 -5.77 -0.3 1.8e-8 Colorectal cancer; CRC cis rs875971 0.522 rs709604 chr7:65497434 A/G cg18912574 chr7:65842487 NCRNA00174 -0.35 -5.97 -0.31 6.17e-9 Aortic root size; CRC cis rs8062405 1.000 rs8062405 chr16:28837906 C/T cg16576597 chr16:28551801 NUPR1 -0.48 -6.89 -0.36 2.81e-11 Cognitive ability (multi-trait analysis);Cognitive ability; CRC cis rs524281 0.861 rs471484 chr11:65955144 A/G cg16950941 chr11:66035639 RAB1B -0.57 -7.23 -0.37 3.45e-12 Electroencephalogram traits; CRC cis rs9549367 0.636 rs486407 chr13:113833499 G/A cg00898013 chr13:113819073 PROZ 0.5 7.43 0.38 9.39e-13 Platelet distribution width; CRC trans rs783540 0.867 rs7167880 chr15:83294436 G/A cg18393722 chr15:85113863 UBE2QP1 -0.39 -6.92 -0.36 2.43e-11 Schizophrenia; CRC cis rs4731207 0.596 rs1871774 chr7:124674898 A/G cg23710748 chr7:124431027 NA -0.39 -6.23 -0.32 1.44e-9 Cutaneous malignant melanoma; CRC cis rs1448094 0.556 rs11610789 chr12:86169541 A/G cg18827107 chr12:86230957 RASSF9 -0.4 -6.12 -0.32 2.65e-9 Major depressive disorder; CRC cis rs6952808 0.689 rs871924 chr7:2047845 A/G cg21782813 chr7:2030301 MAD1L1 0.53 9.35 0.46 1.38e-18 Bipolar disorder and schizophrenia; CRC cis rs2342371 0.756 rs4916492 chr3:196106306 G/A cg15048948 chr3:196158458 UBXN7 0.51 6.26 0.33 1.18e-9 Fat distribution (HIV); CRC trans rs3733585 0.682 rs13124563 chr4:9927553 A/G cg26043149 chr18:55253948 FECH 0.51 7.59 0.39 3.42e-13 Cleft plate (environmental tobacco smoke interaction); CRC cis rs2739330 0.828 rs5760107 chr22:24252597 T/C cg16132339 chr22:24313637 DDTL;DDT 0.61 9.76 0.47 6.23e-20 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs9902453 0.845 rs2321331 chr17:28025528 G/T cg26525008 chr17:28256777 EFCAB5;SSH2 0.6 8.98 0.44 2.17e-17 Coffee consumption (cups per day); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg15097007 chr3:49726899 MST1;RNF123 0.44 6.27 0.33 1.16e-9 Response to antipsychotic treatment; CRC cis rs7591163 1.000 rs940341 chr2:228724726 A/G cg00063174 chr2:228736253 WDR69 -0.48 -6.48 -0.34 3.27e-10 Blood pressure; CRC cis rs514406 0.708 rs536621 chr1:53309097 A/G cg27535305 chr1:53392650 SCP2 -0.44 -7.83 -0.4 6.79e-14 Monocyte count; CRC cis rs2559856 0.935 rs7957666 chr12:102081551 T/C cg12924262 chr12:102091054 CHPT1 0.56 8.29 0.42 2.88e-15 Blood protein levels; CRC cis rs10256972 0.630 rs13235747 chr7:1129123 T/C cg26608667 chr7:1196370 ZFAND2A 0.36 5.72 0.3 2.41e-8 Longevity;Endometriosis; CRC cis rs7197653 0.748 rs11350 chr16:68335392 A/G cg05110241 chr16:68378359 PRMT7 -0.64 -6.45 -0.34 3.89e-10 Magnesium levels; CRC cis rs2153535 0.541 rs9392222 chr6:8467649 G/A cg21535247 chr6:8435926 SLC35B3 0.49 7.4 0.38 1.14e-12 Motion sickness; CRC cis rs10992471 0.603 rs10118939 chr9:95293641 C/G cg14631576 chr9:95140430 CENPP -0.39 -6.75 -0.35 6.5500000000000006e-11 Visceral adipose tissue/subcutaneous adipose tissue ratio; CRC cis rs7224685 0.774 rs8081417 chr17:3902650 T/A cg09597638 chr17:3907349 NA 0.62 9.94 0.48 1.61e-20 Type 2 diabetes; CRC cis rs713587 0.521 rs6545766 chr2:25077856 C/T cg22495460 chr2:25135724 ADCY3 -0.81 -14.99 -0.64 4.59e-39 Body mass index in non-asthmatics; CRC cis rs7772486 0.875 rs9322046 chr6:146393625 A/G cg23711669 chr6:146136114 FBXO30 0.62 10.62 0.51 7.82e-23 Lobe attachment (rater-scored or self-reported); CRC cis rs832540 0.931 rs1445996 chr5:56235548 C/T cg20203395 chr5:56204925 C5orf35 0.41 5.74 0.3 2.14e-8 Coronary artery disease; CRC cis rs7618915 0.547 rs62253700 chr3:52625019 T/A cg10802521 chr3:52805072 NEK4 -0.59 -9.08 -0.45 1.05e-17 Bipolar disorder; CRC cis rs356992 0.915 rs76673 chr2:60749078 G/T cg08426369 chr2:60753602 BCL11A -0.55 -7.7 -0.39 1.63e-13 Educational attainment (years of education); CRC cis rs611744 0.647 rs7016198 chr8:109262752 G/A cg21045802 chr8:109455806 TTC35 0.42 6.63 0.34 1.41e-10 Dupuytren's disease; CRC cis rs8180040 0.966 rs922957 chr3:47422152 G/C cg02527881 chr3:46936655 PTH1R 0.37 6.74 0.35 6.98e-11 Colorectal cancer; CRC cis rs847649 0.765 rs10953383 chr7:102774076 C/T cg18108683 chr7:102477205 FBXL13 0.52 8.27 0.41 3.35e-15 Morning vs. evening chronotype; CRC cis rs739401 0.611 rs2301140 chr11:3022629 C/T cg25174290 chr11:3078921 CARS 0.44 6.34 0.33 7.45e-10 Longevity; CRC trans rs9291683 0.507 rs6845554 chr4:10013173 T/G cg26043149 chr18:55253948 FECH 0.5 7.49 0.38 6.6e-13 Bone mineral density; CRC cis rs447 0.767 rs2691700 chr7:83720054 A/G cg22846510 chr7:83753280 SEMA3A -0.51 -6.12 -0.32 2.64e-9 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs6456156 1.000 rs9457274 chr6:167520865 G/T cg07513332 chr6:167530253 CCR6 0.44 7.97 0.4 2.69e-14 Primary biliary cholangitis; CRC cis rs7605378 0.658 rs4673507 chr2:200710167 G/C cg23649088 chr2:200775458 C2orf69 0.67 10.12 0.49 3.94e-21 Osteoporosis; CRC cis rs7772486 0.840 rs854144 chr6:146360880 G/T cg23711669 chr6:146136114 FBXO30 -0.59 -8.29 -0.42 2.92e-15 Lobe attachment (rater-scored or self-reported); CRC cis rs10504229 0.683 rs35244711 chr8:58117762 T/G cg02290350 chr8:58132656 NA -0.58 -8.16 -0.41 7.29e-15 Developmental language disorder (linguistic errors); CRC cis rs2439831 0.850 rs28595038 chr15:44044859 A/C cg02155558 chr15:43621948 ADAL;LCMT2 0.68 7.47 0.38 7.38e-13 Lung cancer in ever smokers; CRC cis rs853679 0.599 rs156743 chr6:27967089 T/C cg12273811 chr6:28175739 NA 0.59 5.71 0.3 2.53e-8 Depression; CRC cis rs7666738 0.830 rs7679961 chr4:99000202 C/T cg17366294 chr4:99064904 C4orf37 0.44 7.39 0.38 1.19e-12 Colonoscopy-negative controls vs population controls; CRC cis rs208520 0.874 rs208473 chr6:66917265 G/C cg07460842 chr6:66804631 NA -0.94 -12.2 -0.56 1.65e-28 Exhaled nitric oxide output; CRC cis rs7904368 0.754 rs12246217 chr10:16853349 G/C cg14835575 chr10:16859367 RSU1 0.47 6.33 0.33 7.94e-10 Ratio of the peak velocity of the mitral E-Wave divided by the peak velocity of the mitral A-wave.; CRC cis rs11212617 0.935 rs227064 chr11:108207393 T/C cg14761454 chr11:108092087 ATM;NPAT 0.41 6.01 0.31 4.89e-9 Response to metformin in type 2 diabetes (glycemic); CRC cis rs9894429 0.690 rs11869779 chr17:79570067 C/T cg21028142 chr17:79581711 NPLOC4 -0.33 -6.98 -0.36 1.64e-11 Eye color traits; CRC cis rs8032158 0.702 rs11630780 chr15:56128445 G/T cg02198044 chr15:56286336 NEDD4 0.37 5.93 0.31 7.68e-9 Keloid; CRC cis rs9549367 0.713 rs3024756 chr13:113822950 G/C cg24300038 chr13:113819356 PROZ -0.46 -5.78 -0.3 1.71e-8 Platelet distribution width; CRC cis rs3733585 0.699 rs6449174 chr4:9966422 C/T cg11266682 chr4:10021025 SLC2A9 -0.46 -9.17 -0.45 5.23e-18 Cleft plate (environmental tobacco smoke interaction); CRC cis rs6502050 0.835 rs6502065 chr17:80095642 T/C cg11859384 chr17:80120422 CCDC57 -0.37 -5.85 -0.31 1.16e-8 Life satisfaction; CRC trans rs6076960 0.623 rs6038407 chr20:6267326 A/G cg17788362 chr6:86352627 SYNCRIP 0.55 7.5 0.38 5.82e-13 Smooth-surface caries; CRC cis rs9650657 0.513 rs4841459 chr8:10782442 A/C cg27411982 chr8:10470053 RP1L1 -0.42 -6.41 -0.33 4.91e-10 Neuroticism; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg15113064 chr3:124774855 HEG1 0.4 6.18 0.32 1.85e-9 Liver disease severity in Alagille syndrome; CRC trans rs7937682 0.814 rs1784788 chr11:111486136 T/G cg18187862 chr3:45730750 SACM1L 0.45 6.5 0.34 3.01e-10 Primary sclerosing cholangitis; CRC trans rs6011368 0.642 rs6062362 chr20:62911229 A/G cg13869341 chr1:15865 WASH5P 0.4 5.98 0.31 5.66e-9 Clozapine-induced cytotoxicity; CRC trans rs2797160 0.935 rs1739372 chr6:126011325 G/A cg05039488 chr6:79577232 IRAK1BP1 0.49 7.29 0.37 2.25e-12 Endometrial cancer; CRC cis rs1552244 1.000 rs66797209 chr3:10078526 G/A cg13047869 chr3:10149882 C3orf24 0.57 7.76 0.39 1.1e-13 Alzheimer's disease; CRC cis rs8072100 0.967 rs62076549 chr17:45579555 T/G cg25173405 chr17:45401733 C17orf57 0.46 7.25 0.37 2.96e-12 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs9457247 0.967 rs443570 chr6:167389925 G/A cg23791538 chr6:167370224 RNASET2 -0.38 -6.0 -0.31 5.17e-9 Crohn's disease; CRC cis rs1568889 1.000 rs61889027 chr11:28281908 C/T cg06544937 chr11:28130018 METT5D1;KIF18A 0.77 9.76 0.47 6.16e-20 Bipolar disorder; CRC cis rs28830936 0.509 rs6493005 chr15:41859152 A/G cg17847044 chr15:42102381 MAPKBP1 -0.28 -5.67 -0.3 3.11e-8 Diastolic blood pressure; CRC trans rs4650994 0.524 rs2811299 chr1:178586377 A/G cg05059571 chr16:84539110 KIAA1609 0.58 7.87 0.4 5.08e-14 HDL cholesterol levels;HDL cholesterol; CRC cis rs6988985 0.594 rs12543598 chr8:143955318 T/G cg10324643 chr8:143916377 GML 0.38 6.21 0.32 1.6e-9 Plasma androstenedione levels in resected early stage-receptor positive breast cancer; CRC cis rs3096299 0.685 rs8050512 chr16:89552320 C/G cg00750074 chr16:89608354 SPG7 -0.48 -7.44 -0.38 9.06e-13 Multiple myeloma (IgH translocation); CRC cis rs60871478 1.000 rs4397290 chr7:828493 T/C cg05535760 chr7:792225 HEATR2 -0.84 -11.07 -0.52 1.94e-24 Cerebrospinal P-tau181p levels; CRC cis rs6545883 0.542 rs10177225 chr2:61594498 C/T cg10580144 chr2:61372316 C2orf74 -0.37 -8.38 -0.42 1.54e-15 Tuberculosis; CRC cis rs4604732 0.631 rs74154675 chr1:247625836 G/A cg12754571 chr1:247694271 LOC148824;OR2C3 0.41 5.78 0.3 1.74e-8 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CRC trans rs11098499 0.954 rs17009122 chr4:120362403 G/A cg25214090 chr10:38739885 LOC399744 0.66 10.47 0.5 2.41e-22 Corneal astigmatism; CRC cis rs6546324 0.625 rs4260227 chr2:67843537 G/A cg15745817 chr2:67799979 NA -0.55 -9.38 -0.46 1.08e-18 Endometriosis; CRC cis rs9372253 0.934 rs9320327 chr6:110715194 T/A cg01119278 chr6:110721349 DDO -0.38 -6.19 -0.32 1.75e-9 Platelet distribution width; CRC cis rs28386778 0.830 rs67905415 chr17:61841236 G/A cg25654072 chr17:61904446 PSMC5;FTSJ3 0.71 11.05 0.52 2.32e-24 Prudent dietary pattern; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg25147601 chr6:159240341 EZR 0.37 6.04 0.32 4.21e-9 Liver disease severity in Alagille syndrome; CRC cis rs2814982 0.605 rs80254589 chr6:34478514 C/T cg17674042 chr6:34482479 PACSIN1 -1.04 -10.82 -0.51 1.52e-23 Cholesterol, total;Total cholesterol levels; CRC trans rs9329221 0.537 rs1351876 chr8:9984777 A/G cg06636001 chr8:8085503 FLJ10661 -0.49 -7.2 -0.37 4.15e-12 Neuroticism; CRC cis rs10089 1.000 rs4835943 chr5:127457569 A/G cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.72 9.97 0.48 1.28e-20 Ileal carcinoids; CRC cis rs113835537 0.627 rs4630309 chr11:66333072 A/C cg07557337 chr11:66035873 RAB1B 0.55 5.75 0.3 2.04e-8 Airway imaging phenotypes; CRC cis rs6904897 0.563 rs4896117 chr6:135229400 T/C cg22676075 chr6:135203613 NA -0.76 -12.99 -0.58 2.01e-31 Mean corpuscular volume;Mean corpuscular hemoglobin; CRC cis rs7726839 0.561 rs11955068 chr5:582324 C/T cg16447950 chr5:562315 NA -0.85 -12.55 -0.57 8.55e-30 Obesity-related traits; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg02611874 chr10:46194725 NA -0.36 -6.14 -0.32 2.39e-9 Liver disease severity in Alagille syndrome; CRC trans rs7395662 0.929 rs10838956 chr11:48581765 T/C cg21153622 chr11:89784906 NA -0.46 -7.35 -0.38 1.54e-12 HDL cholesterol; CRC cis rs875971 0.862 rs28470208 chr7:65584700 A/G cg12463550 chr7:65579703 CRCP -0.52 -7.31 -0.37 2e-12 Aortic root size; CRC cis rs875971 0.830 rs778715 chr7:65849209 C/T cg18252515 chr7:66147081 NA -0.41 -5.94 -0.31 7.15e-9 Aortic root size; CRC cis rs763121 0.853 rs138706 chr22:39137834 C/G cg06022373 chr22:39101656 GTPBP1 0.8 12.47 0.57 1.7e-29 Menopause (age at onset); CRC cis rs13256369 1.000 rs885000 chr8:8568875 G/T cg00074818 chr8:8560427 CLDN23 0.4 7.27 0.37 2.7e-12 Obesity-related traits; CRC cis rs1448094 0.544 rs56330110 chr12:86166666 A/G cg18827107 chr12:86230957 RASSF9 -0.38 -5.84 -0.31 1.22e-8 Major depressive disorder; CRC cis rs17376456 0.825 rs10075217 chr5:93176774 C/G cg25358565 chr5:93447407 FAM172A 0.99 9.91 0.48 1.92e-20 Diabetic retinopathy; CRC cis rs9372498 0.536 rs7356947 chr6:118767920 A/G cg10217327 chr6:118973057 C6orf204 0.51 5.73 0.3 2.29e-8 Diastolic blood pressure; CRC cis rs2282802 0.685 rs2337138 chr5:139691664 A/C cg26211634 chr5:139558579 C5orf32 0.43 7.26 0.37 2.84e-12 Intelligence (multi-trait analysis); CRC cis rs10504229 0.679 rs1442125 chr8:58036258 A/C cg22535103 chr8:58192502 C8orf71 0.44 5.73 0.3 2.3e-8 Developmental language disorder (linguistic errors); CRC cis rs12188164 0.965 rs72717430 chr5:444502 T/C cg26850624 chr5:429559 AHRR -0.81 -13.6 -0.6 9.63e-34 Cystic fibrosis severity; CRC trans rs11098499 0.542 rs7677836 chr4:120310638 T/A cg25214090 chr10:38739885 LOC399744 0.62 9.74 0.47 7.35e-20 Corneal astigmatism; CRC cis rs7618501 0.633 rs12485600 chr3:50025530 A/G cg24110177 chr3:50126178 RBM5 -0.45 -6.78 -0.35 5.47e-11 Intelligence (multi-trait analysis); CRC trans rs4332037 0.624 rs58169303 chr7:1883274 T/C cg11693508 chr17:37793320 STARD3 0.63 8.19 0.41 5.82e-15 Bipolar disorder; CRC cis rs853679 0.546 rs34295134 chr6:27828151 T/A cg06470822 chr6:28175283 NA 0.66 5.63 0.3 3.82e-8 Depression; CRC cis rs1707322 1.000 rs4390216 chr1:46266456 C/T cg03146154 chr1:46216737 IPP 0.52 7.26 0.37 2.82e-12 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs7259376 0.869 rs11671804 chr19:22591216 A/G cg02657401 chr19:22469223 NA 0.3 6.28 0.33 1.09e-9 Menopause (age at onset); CRC trans rs35110281 0.776 rs2838316 chr21:44990036 C/T cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.54 9.34 0.46 1.53e-18 Mean corpuscular volume; CRC trans rs2014572 0.904 rs10412465 chr19:57753931 T/C cg02674126 chr19:40336878 FBL 0.41 6.64 0.34 1.26e-10 Hyperactive-impulsive symptoms; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg13468249 chr17:7154818 DULLARD;C17orf81 0.52 8.54 0.43 5.22e-16 Liver disease severity in Alagille syndrome; CRC cis rs8060686 0.748 rs3785098 chr16:67993643 T/C cg26727032 chr16:67993705 SLC12A4 -0.71 -10.78 -0.51 2.0500000000000001e-23 HDL cholesterol;Metabolic syndrome; CRC cis rs6503525 0.628 rs4065985 chr17:38101932 G/C cg17344932 chr17:38183730 MED24;SNORD124 -0.44 -6.99 -0.36 1.57e-11 Asthma; CRC cis rs1552244 1.000 rs6793396 chr3:10110927 T/C cg08888203 chr3:10149979 C3orf24 0.73 10.16 0.49 2.86e-21 Alzheimer's disease; CRC cis rs17234274 0.622 rs4923074 chr11:23233797 T/C cg05245346 chr11:23248277 NA 0.34 5.63 0.3 3.79e-8 Cancer; CRC cis rs9341808 0.718 rs12208016 chr6:80823563 G/A cg08355045 chr6:80787529 NA 0.43 6.9 0.36 2.64e-11 Sitting height ratio; CRC cis rs877282 0.898 rs71489279 chr10:760510 T/C cg17470449 chr10:769945 NA 0.64 8.46 0.42 8.88e-16 Uric acid levels; CRC trans rs11039798 0.623 rs584851 chr11:48416321 A/G cg03929089 chr4:120376271 NA -0.62 -6.08 -0.32 3.34e-9 Axial length; CRC cis rs514406 0.505 rs6688064 chr1:53165609 C/T cg24675658 chr1:53192096 ZYG11B -0.67 -10.01 -0.48 8.91e-21 Monocyte count; CRC cis rs7607369 0.559 rs4674343 chr2:219660346 C/T cg02176678 chr2:219576539 TTLL4 0.41 6.65 0.34 1.24e-10 Red blood cell count;Amyotrophic lateral sclerosis; CRC cis rs1707322 0.717 rs10890345 chr1:46213927 C/T cg03146154 chr1:46216737 IPP 0.68 9.85 0.48 3.13e-20 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs643506 1.000 rs1788955 chr11:111630998 C/G cg09085632 chr11:111637200 PPP2R1B 0.5 6.54 0.34 2.39e-10 Breast cancer; CRC cis rs7584330 0.504 rs11891426 chr2:238434702 T/G cg14458575 chr2:238380390 NA 0.39 5.78 0.3 1.72e-8 Prostate cancer; CRC cis rs60843830 1.000 rs3791221 chr2:226933 A/G cg00108164 chr2:264199 ACP1;SH3YL1 0.64 10.21 0.49 1.99e-21 Spherical equivalent (joint analysis main effects and education interaction); CRC cis rs1218582 0.774 rs2335409 chr1:154916106 G/A cg09359103 chr1:154839909 KCNN3 -0.72 -12.13 -0.56 3.03e-28 Prostate cancer; CRC cis rs9368481 0.646 rs75843621 chr6:26967881 G/A cg07220782 chr6:26987966 LOC100270746;C6orf41 -0.41 -5.8 -0.3 1.59e-8 Autism spectrum disorder or schizophrenia; CRC cis rs9462846 0.881 rs34498470 chr6:42879551 C/T cg10862848 chr6:42927986 GNMT -0.3 -5.75 -0.3 2.07e-8 Blood protein levels; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg04590956 chr2:70057467 GMCL1 0.47 6.64 0.34 1.29e-10 Response to antipsychotic treatment; CRC cis rs73206853 0.563 rs73194043 chr12:111188782 G/A cg12870014 chr12:110450643 ANKRD13A 0.73 8.56 0.43 4.32e-16 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg26701943 chr11:108369231 KDELC2 0.37 6.18 0.32 1.92e-9 Liver disease severity in Alagille syndrome; CRC cis rs6662572 0.737 rs10890357 chr1:46318054 T/G cg08644498 chr1:46502608 NA -0.45 -7.07 -0.36 9.42e-12 Blood protein levels; CRC cis rs2066819 1.000 rs77131854 chr12:56664231 C/T cg26714650 chr12:56694279 CS -1.41 -11.64 -0.54 1.88e-26 Psoriasis vulgaris; CRC cis rs3018066 0.748 rs72677306 chr4:106997678 T/C cg01869342 chr4:106983673 TBCK 0.46 6.8 0.35 4.91e-11 Cancer; CRC cis rs3540 0.512 rs11633872 chr15:91080512 G/A cg22089800 chr15:90895588 ZNF774 -0.58 -9.56 -0.47 2.83e-19 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; CRC cis rs6582630 0.512 rs11182667 chr12:38588392 C/A cg26384229 chr12:38710491 ALG10B -0.54 -7.8 -0.4 8.11e-14 Drug-induced liver injury (flucloxacillin); CRC cis rs7615952 0.551 rs6438945 chr3:125634473 G/A cg05084668 chr3:125655381 ALG1L -0.62 -8.39 -0.42 1.43e-15 Blood pressure (smoking interaction); CRC cis rs6840360 1.000 rs1864300 chr4:152663326 T/C cg09659197 chr4:152720779 NA 0.53 11.71 0.54 1.06e-26 Intelligence (multi-trait analysis); CRC cis rs3772130 0.962 rs17742508 chr3:121559895 C/T cg20356878 chr3:121714668 ILDR1 0.52 8.22 0.41 4.87e-15 Cognitive performance; CRC cis rs734999 0.588 rs2843404 chr1:2530558 T/C cg20673091 chr1:2541236 MMEL1 -0.36 -5.78 -0.3 1.76e-8 Ulcerative colitis; CRC trans rs7395662 1.000 rs6485903 chr11:48639004 G/A cg21153622 chr11:89784906 NA -0.48 -7.76 -0.39 1.07e-13 HDL cholesterol; CRC cis rs9486719 0.894 rs34826652 chr6:96899085 A/G cg06623918 chr6:96969491 KIAA0776 -0.81 -9.47 -0.46 5.55e-19 Migraine;Coronary artery disease; CRC cis rs16975963 0.644 rs78644049 chr19:38113042 T/A cg15135657 chr19:38346511 NA -0.46 -6.28 -0.33 1.04e-9 Longevity; CRC cis rs55823223 0.646 rs55868394 chr17:73851113 C/A cg23806715 chr17:73775811 H3F3B 0.66 5.84 0.31 1.26e-8 Psoriasis; CRC cis rs7773004 0.875 rs6456713 chr6:26325843 A/G cg00631329 chr6:26305371 NA -0.4 -6.89 -0.36 2.86e-11 Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for body mass index;Waist circumference adjusted for BMI in non-smokers;Waist circumference adjusted for BMI (adjusted for smoking behaviour); CRC cis rs7258465 1.000 rs10409483 chr19:18590223 C/G cg01065977 chr19:18549689 ISYNA1 -0.41 -6.39 -0.33 5.59e-10 Breast cancer; CRC trans rs12478296 0.792 rs6755390 chr2:243012998 C/T cg18288967 chr1:45987694 PRDX1 0.61 6.72 0.35 7.94e-11 Obesity-related traits; CRC cis rs7618915 0.501 rs12486554 chr3:52742537 A/T cg18099408 chr3:52552593 STAB1 -0.46 -7.79 -0.39 8.91e-14 Bipolar disorder; CRC cis rs6121246 0.559 rs6060932 chr20:30350545 A/G cg13852791 chr20:30311386 BCL2L1 0.78 15.28 0.64 3.22e-40 Mean corpuscular hemoglobin; CRC cis rs736408 0.609 rs62255396 chr3:52782839 C/T cg18404041 chr3:52824283 ITIH1 -0.42 -8.66 -0.43 2.08e-16 Bipolar disorder; CRC cis rs2836974 0.644 rs1882779 chr21:40690938 T/C cg22974920 chr21:40686053 BRWD1 -0.43 -5.74 -0.3 2.11e-8 Cognitive function; CRC cis rs1580019 0.523 rs9791770 chr7:32582252 C/A cg06627557 chr7:32535165 LSM5;AVL9 0.98 18.55 0.71 4.45e-53 Cognitive ability; CRC cis rs4750440 0.642 rs1574583 chr10:14026870 C/G cg00551146 chr10:14014579 FRMD4A 0.47 7.49 0.38 6.42e-13 Adiponectin levels; CRC cis rs17881320 0.510 rs6503699 chr17:40554261 C/G cg05878104 chr17:40932452 WNK4 0.55 6.66 0.34 1.17e-10 Atopic dermatitis; CRC cis rs2204008 0.688 rs12824232 chr12:38175901 G/A cg26384229 chr12:38710491 ALG10B 0.69 9.26 0.45 2.81e-18 Bladder cancer; CRC cis rs72720396 0.789 rs10922910 chr1:91199862 G/T cg13456504 chr1:91191583 NA 0.43 5.94 0.31 7.14e-9 Morning vs. evening chronotype;Chronotype; CRC cis rs77688320 0.535 rs2540441 chr2:202346669 C/T cg00712779 chr2:202317602 STRADB;TRAK2 -0.38 -5.64 -0.3 3.7e-8 Breast cancer; CRC cis rs477692 0.905 rs509041 chr10:131424948 A/G cg26102564 chr10:131424627 MGMT 0.39 5.68 0.3 2.91e-8 Response to temozolomide; CRC trans rs11088226 0.681 rs2833903 chr21:33940819 C/T cg09050820 chr6:167586206 TCP10L2 0.81 8.53 0.43 5.43e-16 Gastritis; CRC cis rs7523050 0.730 rs72984614 chr1:109435848 T/C cg08274380 chr1:109419600 GPSM2 0.89 7.75 0.39 1.18e-13 Fat distribution (HIV); CRC cis rs79387448 0.564 rs77375846 chr2:103155075 T/C cg09003973 chr2:102972529 NA 0.95 9.17 0.45 5.27e-18 Gut microbiota (bacterial taxa); CRC cis rs2386661 0.826 rs11255996 chr10:5670832 G/A cg26603656 chr10:5671107 NA 0.55 9.1 0.45 8.84e-18 Breast cancer; CRC cis rs2976388 0.609 rs2572909 chr8:143806464 C/G cg05569086 chr8:143859399 LYNX1 0.38 6.59 0.34 1.79e-10 Urinary tract infection frequency; CRC cis rs3733585 0.674 rs7375643 chr4:9955239 A/G cg00071950 chr4:10020882 SLC2A9 -0.64 -12.01 -0.55 8.78e-28 Cleft plate (environmental tobacco smoke interaction); CRC cis rs7119 0.717 rs7181283 chr15:77814544 G/A cg27398640 chr15:77910606 LINGO1 -0.44 -7.53 -0.38 4.81e-13 Type 2 diabetes; CRC cis rs8064299 0.597 rs2016126 chr17:72784932 G/A cg25054828 chr17:72772726 NAT9;TMEM104 0.86 14.77 0.63 3.05e-38 Monocyte count; CRC cis rs7584330 0.740 rs2292885 chr2:238443407 G/C cg14458575 chr2:238380390 NA 0.47 8.36 0.42 1.85e-15 Prostate cancer; CRC cis rs34779708 0.897 rs7900480 chr10:35338699 A/G cg03585969 chr10:35415529 CREM -0.6 -8.23 -0.41 4.3e-15 Inflammatory bowel disease;Crohn's disease; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg16773881 chr3:97540493 NA 0.42 5.98 0.31 5.91e-9 Intelligence (multi-trait analysis); CRC cis rs6717918 0.924 rs6718438 chr2:233155566 T/C ch.2.233013039R chr2:233304795 NA 0.49 6.92 0.36 2.3e-11 Height; CRC cis rs28386778 0.897 rs6504176 chr17:61811920 T/C cg06873352 chr17:61820015 STRADA 0.78 14.7 0.63 5.76e-38 Prudent dietary pattern; CRC cis rs12760731 0.582 rs12044868 chr1:178514203 C/A cg00404053 chr1:178313656 RASAL2 0.66 7.44 0.38 8.62e-13 Obesity-related traits; CRC cis rs7043114 0.563 rs987554 chr9:95298738 A/G cg14631576 chr9:95140430 CENPP -0.32 -5.95 -0.31 6.81e-9 Height; CRC cis rs9309473 0.607 rs7567343 chr2:73596605 C/A cg20560298 chr2:73613845 ALMS1 -0.49 -6.83 -0.35 4.01e-11 Metabolite levels; CRC trans rs6550704 0.687 rs9865314 chr3:22634337 A/G cg19793034 chr4:1284190 MAEA -0.41 -6.13 -0.32 2.5e-9 Daytime sleep phenotypes; CRC cis rs10760123 1 rs10760123 chr9:123650534 T/G cg09586646 chr9:123605570 PSMD5;LOC253039 0.53 7.17 0.37 5.09e-12 Allergic disease (asthma, hay fever or eczema); CRC cis rs2929278 0.617 rs575082 chr15:44110142 A/G cg02155558 chr15:43621948 ADAL;LCMT2 -0.41 -5.72 -0.3 2.41e-8 Schizophrenia; CRC cis rs853679 0.517 rs9393895 chr6:28127621 T/C cg23161317 chr6:28129485 ZNF389 0.53 6.44 0.33 4.34e-10 Depression; CRC cis rs7917772 0.503 rs7899576 chr10:104307504 G/A cg11453585 chr10:104263688 ACTR1A;SUFU 0.88 16.58 0.67 2.75e-45 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC trans rs9956878 0.555 rs8085188 chr18:73544676 A/G cg18603276 chr17:8023961 HES7 -0.4 -6.48 -0.34 3.42e-10 Obesity-related traits; CRC cis rs9467711 0.591 rs13220488 chr6:25896907 A/G cg08501292 chr6:25962987 TRIM38 1.15 10.02 0.48 8.32e-21 Autism spectrum disorder or schizophrenia; CRC cis rs9902453 0.967 rs60176674 chr17:28479854 T/C cg26525008 chr17:28256777 EFCAB5;SSH2 0.55 8.3 0.42 2.78e-15 Coffee consumption (cups per day); CRC cis rs1577917 0.917 rs2218594 chr6:86543766 A/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.49 -6.53 -0.34 2.47e-10 Response to antipsychotic treatment; CRC cis rs3733585 0.673 rs6840802 chr4:9965633 C/G cg00071950 chr4:10020882 SLC2A9 0.55 9.4 0.46 9.29e-19 Cleft plate (environmental tobacco smoke interaction); CRC cis rs11997175 0.583 rs7824990 chr8:33779934 A/G ch.8.33884649F chr8:33765107 NA 0.41 5.63 0.3 3.82e-8 Body mass index; CRC cis rs4665809 0.590 rs4665840 chr2:26444962 C/T cg26119090 chr2:26468346 HADHA;HADHB -1.06 -15.5 -0.65 4.69e-41 Gut microbiome composition (summer); CRC cis rs7666738 0.962 rs17550217 chr4:98999699 T/A cg03676636 chr4:99064102 C4orf37 0.24 6.79 0.35 5.26e-11 Colonoscopy-negative controls vs population controls; CRC cis rs4819052 0.819 rs34818688 chr21:46672416 C/T cg19498844 chr21:46707878 POFUT2;LOC642852 0.74 10.71 0.51 3.8e-23 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs34779708 0.931 rs7920095 chr10:35303334 G/A cg03585969 chr10:35415529 CREM 0.67 8.91 0.44 3.47e-17 Inflammatory bowel disease;Crohn's disease; CRC cis rs4713118 0.513 rs149954 chr6:28035246 G/A cg12273811 chr6:28175739 NA 0.57 8.23 0.41 4.41e-15 Parkinson's disease; CRC cis rs9399135 1.000 rs35123050 chr6:135302740 G/A cg22676075 chr6:135203613 NA 0.42 6.41 0.33 5.16e-10 Red blood cell count; CRC cis rs7772486 0.875 rs9322046 chr6:146393625 A/G cg13319975 chr6:146136371 FBXO30 -0.39 -5.94 -0.31 7.38e-9 Lobe attachment (rater-scored or self-reported); CRC trans rs10983614 1.000 rs7867776 chr9:120072627 A/G cg04827747 chr7:134855666 C7orf49 0.44 5.97 0.31 6.25e-9 Survival in pancreatic cancer; CRC trans rs2243480 1.000 rs1873494 chr7:65649899 T/C cg10756647 chr7:56101905 PSPH -0.76 -7.87 -0.4 5.31e-14 Diabetic kidney disease; CRC cis rs9583531 0.628 rs9521914 chr13:111382231 C/A cg24331049 chr13:111365604 ING1 0.51 6.86 0.35 3.43e-11 Coronary artery disease; CRC cis rs514406 0.861 rs2477741 chr1:53265278 A/G cg08859206 chr1:53392774 SCP2 0.45 6.94 0.36 2.08e-11 Monocyte count; CRC cis rs6460942 1.000 rs77494477 chr7:12315302 A/T cg06484146 chr7:12443880 VWDE -0.76 -7.52 -0.38 5.36e-13 Coronary artery disease; CRC trans rs11088226 0.681 rs2833897 chr21:33931792 T/C cg09050820 chr6:167586206 TCP10L2 0.81 8.46 0.42 8.99e-16 Gastritis; CRC cis rs17234274 0.644 rs1482709 chr11:23219359 G/A cg05245346 chr11:23248277 NA 0.36 5.92 0.31 8.22e-9 Cancer; CRC cis rs6570726 0.791 rs6923074 chr6:145893332 T/C cg23711669 chr6:146136114 FBXO30 0.69 11.52 0.54 4.94e-26 Lobe attachment (rater-scored or self-reported); CRC cis rs977987 0.806 rs7188604 chr16:75451170 T/G cg03315344 chr16:75512273 CHST6 0.53 8.96 0.44 2.42e-17 Dupuytren's disease; CRC cis rs875971 0.964 rs11765965 chr7:65842221 A/G cg18912574 chr7:65842487 NCRNA00174 0.36 6.18 0.32 1.88e-9 Aortic root size; CRC cis rs1862618 0.853 rs190414 chr5:56116772 C/A cg12311346 chr5:56204834 C5orf35 -0.75 -9.98 -0.48 1.17e-20 Initial pursuit acceleration; CRC cis rs8180040 0.701 rs7625067 chr3:47095305 T/C cg27129171 chr3:47204927 SETD2 0.69 11.19 0.52 7.66e-25 Colorectal cancer; CRC cis rs10751667 0.666 rs7395267 chr11:962326 C/A cg01483505 chr11:975446 AP2A2 0.46 7.66 0.39 2.11e-13 Alzheimer's disease (late onset); CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg07154196 chr1:29214064 EPB41 -0.43 -6.5 -0.34 3.01e-10 Myopia (pathological); CRC cis rs1322512 1.000 rs1631457 chr6:152946514 C/T cg03415253 chr6:152958462 SYNE1 -0.42 -6.41 -0.33 5.07e-10 Tonometry; CRC cis rs4654899 1.000 rs6426669 chr1:21430584 C/A cg02927042 chr1:21476669 EIF4G3 -0.46 -7.43 -0.38 9.21e-13 Superior frontal gyrus grey matter volume; CRC trans rs1814175 0.817 rs10769598 chr11:49669326 C/G cg11707556 chr5:10655725 ANKRD33B -0.42 -7.98 -0.4 2.49e-14 Height; CRC cis rs7274811 0.901 rs55990870 chr20:32302908 C/T cg03904042 chr20:32255491 NECAB3;C20orf134 -0.52 -6.88 -0.35 3e-11 Height; CRC cis rs3091242 0.933 rs35403885 chr1:25784551 G/A cg23205692 chr1:25664452 TMEM50A -0.4 -5.63 -0.3 3.9e-8 Erythrocyte sedimentation rate; CRC cis rs72799341 1.000 rs35675346 chr16:30936081 G/A cg02466173 chr16:30829666 NA -0.57 -7.36 -0.38 1.52e-12 Diastolic blood pressure; CRC cis rs4700695 0.841 rs428880 chr5:65245133 C/A cg21114390 chr5:65439923 SFRS12 0.57 6.88 0.35 3.05e-11 Facial morphology (factor 19); CRC cis rs11077998 0.935 rs12185276 chr17:80498997 T/C cg10255544 chr17:80519551 FOXK2 0.38 5.98 0.31 5.72e-9 Reticulocyte fraction of red cells; CRC cis rs11123170 0.650 rs2289897 chr2:113977454 G/A cg07594247 chr2:113993304 PAX8;LOC440839;LOC654433 0.46 5.7 0.3 2.71e-8 Renal function-related traits (BUN); CRC cis rs853679 0.517 rs9380060 chr6:28132603 G/A cg06470822 chr6:28175283 NA 1.03 13.59 0.6 1.04e-33 Depression; CRC cis rs10504229 0.953 rs72650891 chr8:58179697 T/G cg02725872 chr8:58115012 NA -0.38 -6.43 -0.33 4.44e-10 Developmental language disorder (linguistic errors); CRC cis rs8064299 0.967 rs878907 chr17:72769694 A/G cg25054828 chr17:72772726 NAT9;TMEM104 0.63 10.06 0.49 6.18e-21 Monocyte count; CRC cis rs2462686 1.000 rs2965071 chr7:46001382 T/A cg15898840 chr7:45960834 IGFBP3 0.38 5.71 0.3 2.58e-8 Major depressive disorder; CRC cis rs67340775 0.541 rs200979 chr6:27852357 G/A cg25164649 chr6:28176230 NA 0.59 5.85 0.31 1.2e-8 Lung cancer in ever smokers; CRC cis rs1023500 0.573 rs2269524 chr22:42475703 T/G cg11915388 chr22:42470451 FAM109B 0.42 6.34 0.33 7.46e-10 Schizophrenia; CRC cis rs4466137 0.953 rs6869030 chr5:83007311 C/T cg16102102 chr5:83017553 HAPLN1 -0.54 -7.88 -0.4 4.69e-14 Prostate cancer; CRC cis rs477692 0.935 rs557158 chr10:131420534 C/T cg05714579 chr10:131428358 MGMT 0.53 7.68 0.39 1.8e-13 Response to temozolomide; CRC cis rs10504229 0.861 rs6990796 chr8:58183097 G/C cg22535103 chr8:58192502 C8orf71 -0.82 -12.27 -0.56 9.63e-29 Developmental language disorder (linguistic errors); CRC cis rs10504229 0.683 rs59679713 chr8:58134370 G/C cg24829409 chr8:58192753 C8orf71 -0.55 -8.03 -0.4 1.71e-14 Developmental language disorder (linguistic errors); CRC cis rs1707322 1.000 rs4660334 chr1:46462126 A/C cg03146154 chr1:46216737 IPP 0.5 6.88 0.35 3.02e-11 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs6120849 0.754 rs6120793 chr20:33604407 T/C cg08999081 chr20:33150536 PIGU 0.45 5.87 0.31 1.06e-8 Protein C levels; CRC cis rs1005224 0.853 rs9323616 chr14:76151697 T/C cg25116370 chr14:76127843 TTLL5;C14orf1 -0.45 -7.0 -0.36 1.44e-11 Large artery stroke; CRC cis rs898097 0.528 rs2243523 chr17:80680449 G/T cg15664640 chr17:80829946 TBCD -0.41 -6.59 -0.34 1.79e-10 Breast cancer; CRC trans rs9929218 1.000 rs4783681 chr16:68806508 C/A cg04657470 chr2:198365150 HSPE1;HSPD1 -0.82 -11.54 -0.54 4.33e-26 Colorectal cancer; CRC cis rs853679 0.517 rs9368552 chr6:28068426 A/G cg06470822 chr6:28175283 NA 1.0 13.33 0.59 1.04e-32 Depression; CRC cis rs6424115 0.830 rs2502999 chr1:24198321 A/G cg10978503 chr1:24200527 CNR2 0.6 11.12 0.52 1.31e-24 Immature fraction of reticulocytes; CRC cis rs798554 0.660 rs2644274 chr7:2854380 A/T cg13628971 chr7:2884303 GNA12 0.41 6.28 0.33 1.06e-9 Height; CRC cis rs826838 1.000 rs1684395 chr12:39083161 T/G cg13010199 chr12:38710504 ALG10B -0.4 -6.03 -0.32 4.35e-9 Heart rate; CRC cis rs9648716 1.000 rs1267618 chr7:140560018 C/T cg10747023 chr7:140774559 NA 0.44 5.76 0.3 1.94e-8 Type 2 diabetes; CRC cis rs6912958 0.781 rs9450755 chr6:88303702 T/C cg08069147 chr6:88032118 GJB7;C6orf162 -0.57 -8.56 -0.43 4.43e-16 Monocyte percentage of white cells; CRC cis rs67478160 0.643 rs4900600 chr14:104291839 A/G cg08213375 chr14:104286397 PPP1R13B 0.64 13.55 0.6 1.48e-33 Schizophrenia; CRC trans rs3960554 0.660 rs55671363 chr7:75793405 T/C cg19862616 chr7:65841803 NCRNA00174 0.87 13.15 0.59 5.07e-32 Eotaxin levels; CRC cis rs10504229 0.817 rs114173899 chr8:58170640 G/T cg05313129 chr8:58192883 C8orf71 -0.47 -6.93 -0.36 2.23e-11 Developmental language disorder (linguistic errors); CRC cis rs10504229 0.683 rs11774847 chr8:58140775 T/A cg21724239 chr8:58056113 NA 0.76 9.41 0.46 8.87e-19 Developmental language disorder (linguistic errors); CRC trans rs3758141 0.527 rs35761635 chr8:18698838 T/C cg08576827 chr20:9075493 PLCB4 -0.76 -6.18 -0.32 1.91e-9 Body mass index (change over time) in gastrointestinal cancer; CRC cis rs17270561 0.541 rs2009610 chr6:25967068 C/T cg17691542 chr6:26056736 HIST1H1C 0.92 10.33 0.49 7.45e-22 Iron status biomarkers; CRC cis rs7772486 0.790 rs6917135 chr6:146152426 T/C cg13319975 chr6:146136371 FBXO30 -0.42 -6.26 -0.33 1.23e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs7829975 0.711 rs4841051 chr8:8685646 C/T cg06636001 chr8:8085503 FLJ10661 -0.56 -9.23 -0.45 3.35e-18 Mood instability; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg15650170 chr7:150783791 AGAP3 0.34 6.23 0.32 1.46e-9 Liver disease severity in Alagille syndrome; CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg15926737 chr12:57853737 GLI1 -0.51 -6.25 -0.33 1.29e-9 Diisocyanate-induced asthma; CRC cis rs7618501 1.000 rs7374277 chr3:49784777 T/C cg24308560 chr3:49941425 MST1R 0.45 7.06 0.36 9.95e-12 Intelligence (multi-trait analysis); CRC cis rs35000415 0.873 rs34748780 chr7:128700153 A/G cg19972273 chr7:128594194 NA 0.71 6.15 0.32 2.2e-9 Systemic lupus erythematosus; CRC cis rs1552244 1.000 rs7610821 chr3:10136150 C/T cg00166722 chr3:10149974 C3orf24 0.63 8.66 0.43 2.22e-16 Alzheimer's disease; CRC cis rs6952808 1.000 rs12699404 chr7:1894022 A/T cg21782813 chr7:2030301 MAD1L1 0.46 7.56 0.38 4.13e-13 Bipolar disorder and schizophrenia; CRC cis rs3772130 0.583 rs58088236 chr3:121561765 C/T cg20356878 chr3:121714668 ILDR1 0.37 6.08 0.32 3.24e-9 Cognitive performance; CRC trans rs2553218 0.690 rs8032415 chr15:54851945 A/G cg14776518 chr15:63892607 FBXL22 0.42 6.59 0.34 1.72e-10 Immune response to smallpox vaccine (IL-6); CRC cis rs2797160 0.967 rs1777182 chr6:126013614 T/A cg05901451 chr6:126070800 HEY2 0.4 6.08 0.32 3.28e-9 Endometrial cancer; CRC cis rs4654899 0.865 rs12119348 chr1:21484633 C/T cg02927042 chr1:21476669 EIF4G3 -0.5 -7.9 -0.4 4.36e-14 Superior frontal gyrus grey matter volume; CRC cis rs597539 0.690 rs11228383 chr11:68623228 T/G cg06112835 chr11:68658793 MRPL21 0.45 6.91 0.36 2.46e-11 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs6088590 0.930 rs6087618 chr20:33288407 C/T cg08999081 chr20:33150536 PIGU 0.52 8.87 0.44 4.73e-17 Coronary artery disease; CRC cis rs711245 0.573 rs7570763 chr2:36800589 A/C cg01206211 chr2:36825736 FEZ2 -0.46 -7.15 -0.37 5.79e-12 Height; CRC cis rs1555895 0.576 rs4362075 chr10:865476 A/G cg10556349 chr10:835070 NA -0.32 -6.1 -0.32 2.97e-9 Survival in rectal cancer; CRC cis rs35264875 0.898 rs56140802 chr11:68861631 G/A cg01993067 chr11:68851601 TPCN2 0.58 6.66 0.34 1.13e-10 Blond vs. brown hair color; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg06134974 chr12:51477539 CSRNP2 0.37 6.8 0.35 4.8e-11 Liver disease severity in Alagille syndrome; CRC cis rs4862750 0.872 rs13101408 chr4:187894777 G/A cg03647317 chr4:187891568 NA -0.55 -10.39 -0.5 4.7e-22 Lobe attachment (rater-scored or self-reported); CRC trans rs10982213 0.830 rs2274163 chr9:117188714 C/T cg14178714 chr15:78370200 TBC1D2B 0.39 6.04 0.32 4.11e-9 Interleukin-6 levels; CRC cis rs7552404 0.924 rs1313071 chr1:76195542 C/G cg22875332 chr1:76189707 ACADM 0.69 10.74 0.51 2.9e-23 Blood metabolite levels;Acylcarnitine levels; CRC trans rs2303319 0.504 rs62189052 chr2:162623869 C/G cg11326919 chr17:43324904 LOC100133991 -0.64 -5.99 -0.31 5.65e-9 Cognitive function; CRC cis rs4604732 0.642 rs10925047 chr1:247640143 A/C cg02104434 chr1:247694406 LOC148824;OR2C3 0.38 6.11 0.32 2.81e-9 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CRC cis rs1215050 0.791 rs13107606 chr4:98823187 C/A cg05340658 chr4:99064831 C4orf37 0.48 7.14 0.37 5.89e-12 Waist-to-hip ratio adjusted for body mass index; CRC cis rs6502050 0.723 rs11657069 chr17:80083809 C/T cg19223190 chr17:80058835 NA -0.39 -6.24 -0.33 1.31e-9 Life satisfaction; CRC cis rs9372498 0.536 rs17080302 chr6:118854037 A/G cg15382696 chr6:118971807 C6orf204 0.61 8.01 0.4 2.07e-14 Diastolic blood pressure; CRC cis rs6502050 0.799 rs4789667 chr17:80162143 C/T cg13198984 chr17:80129470 CCDC57 0.46 8.13 0.41 8.58e-15 Life satisfaction; CRC cis rs9611565 0.840 rs3788584 chr22:41779073 T/A cg06634786 chr22:41940651 POLR3H -0.68 -7.81 -0.4 7.69e-14 Vitiligo; CRC cis rs713587 0.806 rs6737082 chr2:25138040 A/C cg04586622 chr2:25135609 ADCY3 -0.53 -9.67 -0.47 1.25e-19 Body mass index in non-asthmatics; CRC cis rs4700695 0.925 rs4700090 chr5:65412434 C/T cg21114390 chr5:65439923 SFRS12 -0.54 -6.29 -0.33 1.04e-9 Facial morphology (factor 19); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg16189954 chr22:29138267 HSCB;CHEK2 0.41 5.99 0.31 5.61e-9 Response to antipsychotic treatment; CRC cis rs4423214 0.840 rs1790328 chr11:71148038 G/A cg05163923 chr11:71159392 DHCR7 -0.64 -7.87 -0.4 5.08e-14 Vitamin D levels; CRC cis rs3749237 0.576 rs3877784 chr3:49539417 C/T cg03060546 chr3:49711283 APEH 0.69 11.99 0.55 1.02e-27 Resting heart rate; CRC cis rs9457247 1.000 rs406095 chr6:167409087 C/T cg23791538 chr6:167370224 RNASET2 -0.39 -6.08 -0.32 3.37e-9 Crohn's disease; CRC cis rs1692580 0.840 rs262679 chr1:2169792 C/T cg21194808 chr1:2205498 SKI 0.43 6.33 0.33 8.04e-10 Coronary artery disease; CRC cis rs2933343 0.951 rs789220 chr3:128592135 A/G cg11901034 chr3:128598214 ACAD9 0.46 5.72 0.3 2.42e-8 IgG glycosylation; CRC cis rs6665290 0.836 rs56029302 chr1:227203390 G/A cg10327440 chr1:227177885 CDC42BPA -1.01 -21.05 -0.76 6.48e-63 Myeloid white cell count; CRC cis rs3018066 0.831 rs4577583 chr4:106976809 T/C cg01869342 chr4:106983673 TBCK 0.38 5.85 0.31 1.21e-8 Cancer; CRC trans rs73198271 0.583 rs11781985 chr8:8589783 C/T cg02388054 chr16:85524230 NA -0.44 -6.23 -0.32 1.41e-9 Bone ultrasound measurement (broadband ultrasound attenuation); CRC cis rs8062405 0.754 rs151179 chr16:28487056 A/G cg16576597 chr16:28551801 NUPR1 0.46 6.37 0.33 6.39e-10 Cognitive ability (multi-trait analysis);Cognitive ability; CRC cis rs7568498 0.517 rs197261 chr2:161904823 A/G cg16506815 chr2:162101123 NA -0.38 -5.66 -0.3 3.22e-8 Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 3 peripheral neuropathy); CRC cis rs3820068 0.581 rs16851848 chr1:15927698 G/A cg13390004 chr1:15929781 NA 0.49 6.91 0.36 2.45e-11 Systolic blood pressure; CRC cis rs68170813 0.559 rs78064065 chr7:106967440 G/A cg02696742 chr7:106810147 HBP1 -0.56 -6.0 -0.31 5.2e-9 Coronary artery disease; CRC cis rs6060717 0.536 rs6060670 chr20:34481143 C/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.5 -5.96 -0.31 6.51e-9 Hip circumference adjusted for BMI; CRC cis rs12200560 0.505 rs9400166 chr6:97077101 G/A cg06623918 chr6:96969491 KIAA0776 0.52 7.77 0.39 1.02e-13 Coronary heart disease; CRC cis rs1448094 0.791 rs10863114 chr12:86332325 T/C cg02569458 chr12:86230093 RASSF9 0.45 7.65 0.39 2.28e-13 Major depressive disorder; CRC trans rs7618501 1.000 rs34451146 chr3:49813013 C/T cg21659725 chr3:3221576 CRBN 0.9 17.3 0.69 3.92e-48 Intelligence (multi-trait analysis); CRC cis rs7044106 0.734 rs10491784 chr9:123432289 A/C cg09586646 chr9:123605570 PSMD5;LOC253039 0.61 8.91 0.44 3.57e-17 Hip circumference adjusted for BMI; CRC cis rs2439831 0.850 rs28696802 chr15:44140395 T/C cg15269541 chr15:43626905 ADAL -0.49 -5.9 -0.31 9.27e-9 Lung cancer in ever smokers; CRC cis rs951366 0.646 rs1772159 chr1:205759195 G/A cg17178900 chr1:205818956 PM20D1 0.81 12.17 0.56 2.21e-28 Menarche (age at onset); CRC cis rs1336900 0.637 rs35967040 chr1:150555588 A/C cg10589385 chr1:150898437 SETDB1 -0.31 -6.53 -0.34 2.45e-10 Blood protein levels; CRC cis rs10193935 0.792 rs72794590 chr2:42378392 G/A cg27598129 chr2:42591480 NA -0.66 -7.35 -0.38 1.61e-12 Colonoscopy-negative controls vs population controls; CRC cis rs8072100 0.837 rs8070463 chr17:45768836 A/G cg19784903 chr17:45786737 TBKBP1 -0.36 -5.91 -0.31 8.47e-9 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs6547741 1.000 rs6547734 chr2:27830990 G/T cg27432699 chr2:27873401 GPN1 0.77 13.64 0.6 7.11e-34 Oral cavity cancer; CRC cis rs8067545 0.516 rs4925086 chr17:20013459 A/T cg13482628 chr17:19912719 NA 0.45 7.01 0.36 1.38e-11 Schizophrenia; CRC cis rs12484776 0.786 rs73165040 chr22:40538602 C/T cg21771250 chr22:40406049 FAM83F 0.31 5.77 0.3 1.79e-8 Uterine fibroids; CRC cis rs4481887 0.861 rs4486480 chr1:248449714 C/T cg00666640 chr1:248458726 OR2T12 0.55 9.36 0.46 1.29e-18 Common traits (Other); CRC cis rs2115630 0.936 rs11073663 chr15:85260268 A/G cg11189052 chr15:85197271 WDR73 -0.61 -9.77 -0.47 5.95e-20 P wave terminal force; CRC trans rs2228479 0.850 rs17233664 chr16:89810628 C/T cg24644049 chr4:85504048 CDS1 0.9 7.41 0.38 1.05e-12 Skin colour saturation; CRC cis rs6460942 0.544 rs4719292 chr7:12139616 C/T cg06484146 chr7:12443880 VWDE -0.51 -6.06 -0.32 3.72e-9 Coronary artery disease; CRC cis rs12368653 0.666 rs799267 chr12:58113158 C/T cg00677455 chr12:58241039 CTDSP2 -0.43 -6.37 -0.33 6.24e-10 Multiple sclerosis; CRC cis rs4711350 0.765 rs943476 chr6:33750086 A/G cg07979401 chr6:33739406 LEMD2 -0.44 -5.65 -0.3 3.54e-8 Schizophrenia; CRC cis rs17209837 1.000 rs45526438 chr7:87089927 G/A cg00919237 chr7:87102261 ABCB4 -0.47 -5.63 -0.3 3.84e-8 Gallbladder cancer; CRC cis rs9733 0.650 rs4970923 chr1:150608300 A/G cg17724175 chr1:150552817 MCL1 -0.48 -7.6 -0.39 3.18e-13 Tonsillectomy; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg24106215 chr1:202927166 ADIPOR1 0.44 6.06 0.32 3.8e-9 Response to antipsychotic treatment; CRC cis rs116095464 0.558 rs56342538 chr5:225796 T/C cg22496380 chr5:211416 CCDC127 -0.84 -9.73 -0.47 7.72e-20 Breast cancer; CRC cis rs6748734 1.000 rs6724662 chr2:241831560 A/G cg07537917 chr2:241836409 C2orf54 -0.21 -5.95 -0.31 6.8e-9 Urinary metabolites; CRC cis rs7487075 0.893 rs1492894 chr12:46728668 C/T cg22049899 chr12:47219821 SLC38A4 0.34 6.6 0.34 1.66e-10 Itch intensity from mosquito bite; CRC cis rs734999 0.545 rs41300092 chr1:2537838 C/T cg20673091 chr1:2541236 MMEL1 0.37 5.91 0.31 8.45e-9 Ulcerative colitis; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg01025762 chr7:107531363 DLD 0.43 6.11 0.32 2.81e-9 Response to antipsychotic treatment; CRC cis rs62064224 0.589 rs6505295 chr17:30687522 G/C cg09324608 chr17:30823087 MYO1D 0.33 5.72 0.3 2.42e-8 Schizophrenia; CRC trans rs2553218 0.690 rs8032415 chr15:54851945 A/G cg10858369 chr11:6476139 TRIM3 0.45 6.45 0.34 4.01e-10 Immune response to smallpox vaccine (IL-6); CRC cis rs644799 0.965 rs2508713 chr11:95547927 T/A cg03916912 chr11:95522834 CEP57;FAM76B 0.93 17.68 0.7 1.19e-49 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs8014204 0.935 rs2300596 chr14:75353855 C/T cg06998765 chr14:75389618 RPS6KL1 -0.24 -5.82 -0.31 1.43e-8 Caffeine consumption; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg11691170 chr11:130318691 ADAMTS15 -0.41 -6.29 -0.33 1.01e-9 Myopia (pathological); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg01603508 chr16:30937154 FBXL19 -0.4 -6.6 -0.34 1.65e-10 Liver disease severity in Alagille syndrome; CRC cis rs9611565 0.722 rs202635 chr22:41809637 C/T cg06634786 chr22:41940651 POLR3H 0.62 7.16 0.37 5.44e-12 Vitiligo; CRC cis rs66573146 1.000 rs73202122 chr4:7005594 G/A cg15105060 chr4:7024189 TBC1D14 -0.75 -5.67 -0.3 3.16e-8 Granulocyte percentage of myeloid white cells; CRC cis rs6565180 1.000 rs11646130 chr16:30376959 T/C cg17640201 chr16:30407289 ZNF48 -0.77 -12.22 -0.56 1.49e-28 Tonsillectomy; CRC cis rs7546094 1.000 rs6666579 chr1:113132393 A/G cg22162597 chr1:113214053 CAPZA1 0.43 6.04 0.32 4.24e-9 Platelet distribution width; CRC cis rs17376456 0.877 rs17315943 chr5:93442830 T/C cg21475434 chr5:93447410 FAM172A 0.74 7.63 0.39 2.64e-13 Diabetic retinopathy; CRC cis rs7769051 0.803 rs59740783 chr6:133231711 G/A cg07930552 chr6:133119739 C6orf192 0.58 6.61 0.34 1.52e-10 Type 2 diabetes nephropathy; CRC cis rs9916302 0.808 rs12948906 chr17:37644854 C/T cg00129232 chr17:37814104 STARD3 -0.55 -8.11 -0.41 9.81e-15 Glomerular filtration rate (creatinine); CRC trans rs11098499 1.000 rs11098499 chr4:120187611 C/T cg25214090 chr10:38739885 LOC399744 0.52 7.99 0.4 2.28e-14 Corneal astigmatism; CRC cis rs597539 0.615 rs629426 chr11:68671104 A/G cg06112835 chr11:68658793 MRPL21 0.47 7.56 0.38 3.99e-13 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs11719291 0.584 rs13080725 chr3:49076092 G/A cg07636037 chr3:49044803 WDR6 -0.82 -6.7 -0.35 9.21e-11 Cognitive function; CRC cis rs6456156 0.565 rs2181058 chr6:167465330 A/T cg07741184 chr6:167504864 NA 0.39 6.91 0.36 2.54e-11 Primary biliary cholangitis; CRC cis rs6951245 0.554 rs79367977 chr7:1152657 G/A cg04025307 chr7:1156635 C7orf50 0.66 8.33 0.42 2.16e-15 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs7618501 0.501 rs35275715 chr3:49959148 A/G cg05623727 chr3:50126028 RBM5 0.58 10.03 0.48 7.71e-21 Intelligence (multi-trait analysis); CRC cis rs875971 1.000 rs6958277 chr7:65979349 A/G cg11764359 chr7:65958608 NA 0.63 10.26 0.49 1.3e-21 Aortic root size; CRC cis rs853679 0.569 rs9348798 chr6:28143011 G/A cg12963246 chr6:28129442 ZNF389 0.5 5.75 0.3 2e-8 Depression; CRC cis rs11792861 0.591 rs10979613 chr9:111687584 A/G cg14432460 chr9:111696404 IKBKAP;C9orf6 0.5 7.37 0.38 1.37e-12 Menarche (age at onset); CRC cis rs10221833 0.602 rs355879 chr2:165633427 T/C cg03182029 chr2:165697222 COBLL1 0.49 5.8 0.3 1.56e-8 Response to statin therapy; CRC cis rs477692 0.792 rs12762024 chr10:131441055 G/C cg05714579 chr10:131428358 MGMT -0.65 -9.27 -0.46 2.54e-18 Response to temozolomide; CRC cis rs1862618 0.671 rs906631 chr5:56245803 C/G cg18230493 chr5:56204884 C5orf35 0.6 8.95 0.44 2.64e-17 Initial pursuit acceleration; CRC cis rs1451375 0.669 rs4512339 chr7:50646977 C/T cg18232548 chr7:50535776 DDC -0.47 -6.57 -0.34 1.99e-10 Malaria; CRC cis rs7259376 0.936 rs10454118 chr19:22559605 C/G cg02657401 chr19:22469223 NA 0.34 7.4 0.38 1.14e-12 Menopause (age at onset); CRC cis rs6901250 0.807 rs339303 chr6:117176691 C/T cg12892004 chr6:117198278 RFX6 -0.43 -6.76 -0.35 6.21e-11 C-reactive protein levels; CRC cis rs4727027 0.901 rs1534198 chr7:148772323 T/C cg23583168 chr7:148888333 NA -0.89 -15.29 -0.64 2.99e-40 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC cis rs1395 0.778 rs12465084 chr2:27414203 G/C cg14242246 chr2:27434262 C2orf28;SLC5A6 0.4 7.33 0.37 1.74e-12 Blood metabolite levels; CRC cis rs4363385 0.818 rs2651413 chr1:153012068 T/A cg25856811 chr1:152973957 SPRR3 -0.25 -6.99 -0.36 1.51e-11 Inflammatory skin disease; CRC cis rs727505 1.000 rs56387611 chr7:124479180 G/A cg23710748 chr7:124431027 NA -0.85 -15.13 -0.64 1.26e-39 Lewy body disease; CRC cis rs12291225 0.753 rs1431374 chr11:14303975 T/C cg19336497 chr11:14380999 RRAS2 -0.52 -8.47 -0.42 8.21e-16 Sense of smell; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg26379672 chr3:4534954 ITPR1 0.45 6.34 0.33 7.69e-10 Response to antipsychotic treatment; CRC cis rs9322193 0.887 rs3777949 chr6:149917157 G/A cg00933542 chr6:150070202 PCMT1 0.31 6.23 0.32 1.43e-9 Lung cancer; CRC cis rs9916302 0.904 rs2061342 chr17:37405657 T/G cg03013999 chr17:37608204 MED1 0.49 7.44 0.38 8.92e-13 Glomerular filtration rate (creatinine); CRC cis rs2845885 0.744 rs2701540 chr11:63869107 T/A cg24431193 chr11:63883947 FLRT1;MACROD1 -0.67 -5.98 -0.31 5.67e-9 Body mass index; CRC cis rs7552404 0.691 rs5745449 chr1:76344711 A/T cg10523679 chr1:76189770 ACADM -0.68 -8.41 -0.42 1.26e-15 Blood metabolite levels;Acylcarnitine levels; CRC cis rs5750830 0.594 rs6001587 chr22:39819008 T/C cg11247378 chr22:39784982 NA -0.41 -7.4 -0.38 1.11e-12 Intelligence (multi-trait analysis); CRC cis rs6424115 0.862 rs34845821 chr1:24066486 C/T cg15997130 chr1:24165203 NA -0.65 -8.07 -0.41 1.29e-14 Immature fraction of reticulocytes; CRC cis rs9929218 1.000 rs13334471 chr16:68800452 T/C cg02972257 chr16:68554789 NA 0.44 5.61 0.3 4.28e-8 Colorectal cancer; CRC cis rs79349575 0.783 rs17635252 chr17:47006950 T/C cg00947319 chr17:47005597 UBE2Z -0.35 -5.99 -0.31 5.54e-9 Type 2 diabetes; CRC cis rs875971 0.862 rs6959268 chr7:65812966 G/A cg11764359 chr7:65958608 NA -0.61 -9.44 -0.46 6.9e-19 Aortic root size; CRC cis rs1865760 0.613 rs9358894 chr6:25923315 C/T cg12310025 chr6:25882481 NA -0.47 -7.08 -0.36 8.62e-12 Height; CRC trans rs2303319 0.504 rs72870226 chr2:162420429 T/C cg09481857 chr22:21368659 P2RX6;MGC16703 -0.64 -6.1 -0.32 3.04e-9 Cognitive function; CRC cis rs10504229 0.861 rs116923397 chr8:58185162 T/G cg01721255 chr8:58191610 C8orf71 0.49 6.16 0.32 2.13e-9 Developmental language disorder (linguistic errors); CRC cis rs8058578 1.000 rs7198250 chr16:30746822 C/A cg00531865 chr16:30841666 NA -0.47 -6.57 -0.34 1.99e-10 Multiple myeloma; CRC cis rs2290405 0.527 rs4690332 chr4:910520 C/T cg12601576 chr4:906860 GAK 0.45 6.61 0.34 1.56e-10 Systemic sclerosis; CRC cis rs1577917 1.000 rs955196 chr6:86729951 G/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A 0.51 6.43 0.33 4.43e-10 Response to antipsychotic treatment; CRC cis rs801193 0.569 rs11772819 chr7:66217970 T/C cg12463550 chr7:65579703 CRCP 0.45 6.04 0.32 4.14e-9 Aortic root size; CRC cis rs1707322 1.000 rs11211190 chr1:46266255 C/T cg03146154 chr1:46216737 IPP 0.52 7.25 0.37 3.01e-12 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs704795 0.805 rs1728926 chr2:27612937 A/G cg17158414 chr2:27665306 KRTCAP3 -0.28 -6.01 -0.31 4.88e-9 Menopause (age at onset); CRC cis rs7301016 0.846 rs11174576 chr12:63026436 C/T cg01804193 chr12:63026212 NA 0.53 5.66 0.3 3.28e-8 IgG glycosylation; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg04393905 chr3:53381207 DCP1A 0.49 6.18 0.32 1.92e-9 Thyroid stimulating hormone; CRC cis rs62064224 0.589 rs2344976 chr17:30685935 T/C cg09324608 chr17:30823087 MYO1D 0.33 5.65 0.3 3.54e-8 Schizophrenia; CRC cis rs9894429 1.000 rs9674872 chr17:79581931 T/A cg13777783 chr17:79615861 NA -0.3 -5.72 -0.3 2.44e-8 Eye color traits; CRC cis rs589448 0.967 rs2617835 chr12:69753420 C/A cg20891283 chr12:69753455 YEATS4 0.99 21.36 0.76 4.12e-64 Cerebrospinal fluid biomarker levels; CRC cis rs514406 0.505 rs431427 chr1:53179094 C/A cg24675658 chr1:53192096 ZYG11B -0.66 -9.92 -0.48 1.78e-20 Monocyte count; CRC cis rs67981189 0.529 rs61990380 chr14:71471946 G/A cg15910301 chr14:71632612 NA 0.3 6.03 0.32 4.37e-9 Schizophrenia; CRC cis rs6831352 0.959 rs4699710 chr4:100051819 C/T cg13256891 chr4:100009986 ADH5 0.61 8.71 0.43 1.48e-16 Alcohol dependence; CRC cis rs7493 0.950 rs7785846 chr7:95033841 C/T cg17330251 chr7:94953956 PON1 -0.56 -7.39 -0.38 1.23e-12 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs1580019 0.510 rs4723162 chr7:32543804 C/A cg07520158 chr7:32535189 LSM5;AVL9 0.54 8.01 0.4 1.96e-14 Cognitive ability; CRC cis rs7044106 0.762 rs7357638 chr9:123389204 G/A cg14255062 chr9:123606675 PSMD5;LOC253039 0.43 6.3 0.33 9.6e-10 Hip circumference adjusted for BMI; CRC cis rs7618501 0.633 rs2624843 chr3:49997963 G/A cg24110177 chr3:50126178 RBM5 -0.5 -7.66 -0.39 2.06e-13 Intelligence (multi-trait analysis); CRC cis rs7671266 0.628 rs11734783 chr4:10240663 C/T cg11266682 chr4:10021025 SLC2A9 0.39 5.91 0.31 8.58e-9 Cardiovascular disease risk factors; CRC cis rs7618915 0.524 rs12488461 chr3:52698417 T/C cg07507251 chr3:52567010 NT5DC2 0.46 6.6 0.34 1.68e-10 Bipolar disorder; CRC cis rs71007656 1 rs71007656 chr10:37970845 CGGCTG/C cg25517755 chr10:38738941 LOC399744 -0.4 -5.61 -0.3 4.4e-8 Extrinsic epigenetic age acceleration; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg24414038 chr1:173793430 CENPL;DARS2 0.44 6.16 0.32 2.12e-9 Response to antipsychotic treatment; CRC cis rs853679 0.550 rs1233707 chr6:28172953 G/A cg12172441 chr6:28176163 NA 0.68 9.05 0.45 1.29e-17 Depression; CRC cis rs2836974 0.583 rs2735307 chr21:40713358 C/T cg11890956 chr21:40555474 PSMG1 0.68 10.06 0.48 6.34e-21 Cognitive function; CRC cis rs13191362 1.000 rs13195226 chr6:163006421 A/G cg06582575 chr6:163149167 PACRG;PARK2 0.73 10.55 0.5 1.3e-22 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs561341 1.000 rs55962687 chr17:30260369 C/T cg19193384 chr17:30244184 NA -0.62 -7.03 -0.36 1.18e-11 Hip circumference adjusted for BMI; CRC cis rs4722166 0.603 rs7801406 chr7:22788274 A/G cg05472934 chr7:22766657 IL6 0.77 12.6 0.57 5.43e-30 Lung cancer; CRC cis rs7618501 0.665 rs7621352 chr3:50070763 A/C cg24110177 chr3:50126178 RBM5 0.47 7.08 0.36 8.68e-12 Intelligence (multi-trait analysis); CRC cis rs2239547 0.657 rs7620706 chr3:52891756 A/T cg15147215 chr3:52552868 STAB1 -0.41 -5.63 -0.3 3.88e-8 Schizophrenia; CRC cis rs9902453 0.967 rs8072664 chr17:28333385 A/G cg26525008 chr17:28256777 EFCAB5;SSH2 -0.59 -8.86 -0.44 4.95e-17 Coffee consumption (cups per day); CRC cis rs709400 0.894 rs10143293 chr14:104063014 G/A cg24130564 chr14:104152367 KLC1 -0.4 -5.63 -0.3 3.85e-8 Body mass index; CRC cis rs7772486 0.875 rs9403768 chr6:146406458 A/C cg23711669 chr6:146136114 FBXO30 0.66 11.56 0.54 3.61e-26 Lobe attachment (rater-scored or self-reported); CRC cis rs7799006 0.929 rs745565 chr7:2256689 G/C cg08027265 chr7:2291960 NA -0.4 -5.98 -0.31 5.8e-9 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs2797160 1.000 rs1777183 chr6:126011995 A/C cg05901451 chr6:126070800 HEY2 0.39 6.03 0.32 4.5e-9 Endometrial cancer; CRC cis rs10540 1.000 rs61876326 chr11:467368 A/G cg21784768 chr11:537496 LRRC56 -0.59 -5.64 -0.3 3.67e-8 Body mass index; CRC cis rs6089584 0.962 rs6142913 chr20:60566950 A/G cg06108461 chr20:60628389 TAF4 -0.81 -13.92 -0.61 5.92e-35 Body mass index; CRC cis rs7618501 0.516 rs2856236 chr3:50161717 A/C cg24110177 chr3:50126178 RBM5 0.45 6.67 0.35 1.09e-10 Intelligence (multi-trait analysis); CRC cis rs172166 0.694 rs203893 chr6:28062066 C/A cg03623178 chr6:28175578 NA 0.8 11.89 0.55 2.27e-27 Cardiac Troponin-T levels; CRC trans rs11671005 0.504 rs3794964 chr19:59070916 T/C cg22037779 chr5:139682734 PFDN1 -0.58 -8.21 -0.41 4.97e-15 Mean platelet volume; CRC cis rs9463078 0.665 rs227849 chr6:44698708 C/T cg25276700 chr6:44698697 NA 0.29 7.31 0.37 2.07e-12 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; CRC trans rs1728785 1.000 rs11648314 chr16:68596775 A/G cg04657470 chr2:198365150 HSPE1;HSPD1 0.75 9.0 0.44 1.88e-17 Ulcerative colitis; CRC cis rs7647973 1.000 rs13322887 chr3:49555583 G/A cg07636037 chr3:49044803 WDR6 -0.67 -8.02 -0.4 1.87e-14 Menarche (age at onset); CRC cis rs1223397 0.651 rs2439534 chr6:13305757 C/T cg07912922 chr6:13274314 PHACTR1 -0.39 -5.99 -0.31 5.48e-9 Blood pressure; CRC cis rs7618915 0.501 rs6804145 chr3:52694198 C/T cg18404041 chr3:52824283 ITIH1 -0.41 -8.66 -0.43 2.11e-16 Bipolar disorder; CRC cis rs6809651 0.524 rs10937240 chr3:185802823 C/T cg00760338 chr3:185826511 ETV5 -0.74 -9.26 -0.45 2.78e-18 Body mass index in physically active individuals;Glomerular filtration rate (creatinine);Body mass index (joint analysis main effects and physical activity interaction);Body mass index;Body mass index in physically inactive individuals; CRC cis rs1552244 1.000 rs55882090 chr3:10139082 C/T cg02579736 chr3:10068473 FANCD2;CIDECP 0.92 12.66 0.57 3.43e-30 Alzheimer's disease; CRC cis rs684232 0.602 rs416662 chr17:535699 A/G cg15660573 chr17:549704 VPS53 -0.86 -15.79 -0.66 3.27e-42 Prostate cancer; CRC cis rs79349575 0.756 rs2643361 chr17:46977462 T/G cg22482690 chr17:47019901 SNF8 0.49 8.2 0.41 5.55e-15 Type 2 diabetes; CRC cis rs11212617 0.901 rs4754301 chr11:108048541 G/A cg14761454 chr11:108092087 ATM;NPAT 0.43 6.46 0.34 3.67e-10 Response to metformin in type 2 diabetes (glycemic); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg00745838 chr9:140100374 TMEM203;NDOR1 0.46 6.44 0.33 4.29e-10 Response to antipsychotic treatment; CRC cis rs7584330 0.554 rs77956735 chr2:238399130 C/T cg08992911 chr2:238395768 MLPH 0.6 6.07 0.32 3.56e-9 Prostate cancer; CRC cis rs4268898 0.717 rs2543662 chr2:24443271 G/T cg06627628 chr2:24431161 ITSN2 0.63 8.94 0.44 2.79e-17 Asthma; CRC cis rs11122272 0.766 rs2808614 chr1:231550168 A/G cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX 0.64 9.93 0.48 1.74e-20 Hemoglobin concentration; CRC cis rs7811142 1.000 rs113738841 chr7:100081306 C/T cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.92 12.27 0.56 9.74e-29 Platelet count; CRC cis rs644148 0.933 rs565819 chr19:44967714 A/G cg15540054 chr19:45004280 ZNF180 0.67 9.5 0.46 4.35e-19 Personality dimensions; CRC cis rs6951245 1.000 rs77702926 chr7:1088838 G/A cg18402987 chr7:1209562 NA 0.64 6.67 0.35 1.05e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg03133917 chr7:155436674 RBM33 0.46 5.96 0.31 6.35e-9 Thyroid stimulating hormone; CRC cis rs10870270 1.000 rs10781564 chr10:133757922 A/G cg17892150 chr10:133769511 PPP2R2D -0.73 -11.14 -0.52 1.16e-24 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; CRC trans rs9291683 0.554 rs7668175 chr4:10125782 T/C cg26043149 chr18:55253948 FECH -0.58 -8.96 -0.44 2.41e-17 Bone mineral density; CRC cis rs7772486 0.790 rs2253768 chr6:146199922 A/G cg23711669 chr6:146136114 FBXO30 0.75 13.04 0.58 1.3e-31 Lobe attachment (rater-scored or self-reported); CRC cis rs79976124 0.879 rs77185357 chr6:66629070 G/A cg07460842 chr6:66804631 NA 0.76 9.41 0.46 8.96e-19 Type 2 diabetes; CRC cis rs17152411 0.895 rs7094116 chr10:126587644 T/G cg07906193 chr10:126599966 NA 0.56 6.4 0.33 5.22e-10 Height; CRC cis rs870825 0.929 rs72689258 chr4:185590550 G/C cg04058563 chr4:185651563 MLF1IP 0.56 5.89 0.31 9.54e-9 Blood protein levels; CRC cis rs9902453 0.838 rs8064689 chr17:28217053 C/T cg26525008 chr17:28256777 EFCAB5;SSH2 0.59 8.8 0.44 7.67e-17 Coffee consumption (cups per day); CRC cis rs7590720 0.819 rs1344694 chr2:216893637 T/G cg12620499 chr2:216877984 MREG 0.96 17.77 0.7 5.17e-50 Alcohol dependence; CRC cis rs10832963 1.000 rs4757676 chr11:18640477 C/T cg20219074 chr11:18656078 SPTY2D1 0.61 8.63 0.43 2.58e-16 Breast cancer; CRC trans rs60843830 1.000 rs62114501 chr2:231741 C/T cg11347411 chr7:150020925 ACTR3C;LRRC61 0.6 9.35 0.46 1.43e-18 Spherical equivalent (joint analysis main effects and education interaction); CRC cis rs9372498 0.536 rs62421536 chr6:118727972 G/A cg18833306 chr6:118973337 C6orf204 0.45 5.69 0.3 2.88e-8 Diastolic blood pressure; CRC cis rs897984 0.542 rs11864806 chr16:31095204 G/C cg02466173 chr16:30829666 NA -0.59 -8.97 -0.44 2.32e-17 Dementia with Lewy bodies; CRC trans rs1376359 0.636 rs1451040 chr1:103158738 A/G cg16220183 chr17:56609687 SEPT4 0.45 6.13 0.32 2.58e-9 QRS duration in Tripanosoma cruzi seropositivity; CRC cis rs4728302 0.869 rs2042456 chr7:133580447 G/A cg10665199 chr7:133106180 EXOC4 0.42 6.32 0.33 8.64e-10 Intelligence;Intelligence (multi-trait analysis); CRC cis rs17384381 1.000 rs12743049 chr1:85897386 G/A cg16011679 chr1:85725395 C1orf52 0.64 6.7 0.35 9.13e-11 Lobe attachment (rater-scored or self-reported); CRC cis rs7617480 0.648 rs6806356 chr3:48727636 G/A cg20833759 chr3:49053208 WDR6;DALRD3 0.58 9.05 0.45 1.25e-17 Subjective well-being (multi-trait analysis);Menarche (age at onset); CRC cis rs7618915 0.547 rs8906 chr3:52739520 T/C cg08222913 chr3:52553049 STAB1 -0.33 -5.88 -0.31 9.89e-9 Bipolar disorder; CRC cis rs1200821 0.535 rs1938417 chr10:37687520 A/C cg00409905 chr10:38381863 ZNF37A 0.45 6.93 0.36 2.2e-11 Hemostatic factors and hematological phenotypes; CRC cis rs13108904 0.935 rs1620928 chr4:1279124 C/T cg02018176 chr4:1364513 KIAA1530 -0.45 -7.67 -0.39 1.99e-13 Obesity-related traits; CRC cis rs2645694 0.626 rs904050 chr4:77826089 T/G cg06046430 chr4:77819534 ANKRD56 0.42 5.73 0.3 2.29e-8 Emphysema distribution in smoking; CRC cis rs6500395 1.000 rs12597928 chr16:48714366 G/A cg04672837 chr16:48644449 N4BP1 -0.45 -6.63 -0.34 1.38e-10 Response to tocilizumab in rheumatoid arthritis; CRC cis rs875971 1.000 rs1144894 chr7:65542894 A/G cg12463550 chr7:65579703 CRCP -0.49 -6.98 -0.36 1.6e-11 Aortic root size; CRC cis rs6543140 0.964 rs10169192 chr2:103072211 A/G cg03938978 chr2:103052716 IL18RAP 0.41 6.54 0.34 2.37e-10 Blood protein levels; CRC cis rs9393692 0.645 rs4145910 chr6:26313305 T/C cg00631329 chr6:26305371 NA -0.72 -12.9 -0.58 4.4e-31 Educational attainment; CRC cis rs6163 0.727 rs284862 chr10:104572081 C/T cg04362960 chr10:104952993 NT5C2 -0.54 -7.66 -0.39 2.09e-13 Waist circumference;Hip circumference; CRC cis rs17767392 1.000 rs17178045 chr14:71756358 A/G cg13720639 chr14:72061746 SIPA1L1 -0.53 -6.82 -0.35 4.34e-11 Mitral valve prolapse; CRC cis rs8005677 0.828 rs4981450 chr14:23389304 A/G cg25600027 chr14:23388339 RBM23 -0.46 -6.9 -0.36 2.66e-11 Cognitive ability (multi-trait analysis); CRC cis rs2204008 0.743 rs2127952 chr12:37995364 G/T cg13010199 chr12:38710504 ALG10B 0.47 6.23 0.32 1.4e-9 Bladder cancer; CRC trans rs10982213 0.830 rs2274163 chr9:117188714 C/T cg16357719 chr16:2317538 RNPS1 0.41 6.64 0.34 1.3100000000000001e-10 Interleukin-6 levels; CRC cis rs2797160 1.000 rs2797161 chr6:126010789 A/G cg05901451 chr6:126070800 HEY2 0.38 5.96 0.31 6.37e-9 Endometrial cancer; CRC cis rs992157 0.661 rs17653757 chr2:219109364 G/C cg04731861 chr2:219085781 ARPC2 -0.32 -6.82 -0.35 4.38e-11 Colorectal cancer; CRC cis rs734999 0.588 rs4648653 chr1:2535895 C/T cg18854424 chr1:2615690 NA 0.41 7.75 0.39 1.13e-13 Ulcerative colitis; CRC cis rs3815700 1.000 rs10404211 chr19:33093565 C/T cg02997394 chr19:33096574 ANKRD27 0.67 6.58 0.34 1.88e-10 Eosinophilic esophagitis; CRC cis rs6952808 0.689 rs79950306 chr7:2022063 C/G cg21782813 chr7:2030301 MAD1L1 0.55 9.37 0.46 1.21e-18 Bipolar disorder and schizophrenia; CRC cis rs2832191 0.755 rs2832193 chr21:30493589 T/C cg08807101 chr21:30365312 RNF160 -0.63 -9.94 -0.48 1.55e-20 Dental caries; CRC cis rs9287719 0.967 rs10195802 chr2:10754532 C/T cg00105475 chr2:10696890 NA 0.45 7.17 0.37 4.88e-12 Prostate cancer; CRC cis rs972578 0.837 rs5751390 chr22:43259541 A/C cg01576275 chr22:43409880 NA -0.4 -6.22 -0.32 1.5e-9 Mean platelet volume; CRC cis rs9388451 0.531 rs9401850 chr6:126151000 T/G cg05901451 chr6:126070800 HEY2 -0.4 -5.83 -0.31 1.29e-8 Brugada syndrome; CRC cis rs12983728 1.000 rs12983728 chr19:58671267 G/A cg21877656 chr19:58662188 ZNF329 0.65 7.05 0.36 1.08e-11 Cholesterol, total; CRC cis rs11212617 0.967 rs7395528 chr11:108056708 A/C cg14761454 chr11:108092087 ATM;NPAT 0.43 6.5 0.34 3.03e-10 Response to metformin in type 2 diabetes (glycemic); CRC cis rs9611565 0.649 rs5758344 chr22:41817685 G/A cg03806693 chr22:41940476 POLR3H 1.1 13.39 0.59 6.08e-33 Vitiligo; CRC cis rs2288912 0.807 rs3760626 chr19:45457105 A/G cg13119609 chr19:45449297 APOC2 0.31 5.9 0.31 9.2e-9 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs4481887 1.000 rs4244172 chr1:248466838 A/G cg13385794 chr1:248469461 NA 0.39 6.93 0.36 2.21e-11 Common traits (Other); CRC cis rs910316 0.967 rs4899551 chr14:75660246 C/G cg11812906 chr14:75593930 NEK9 -0.51 -7.64 -0.39 2.43e-13 Height; CRC cis rs10971721 0.822 rs56160720 chr9:33899825 T/C cg13495928 chr9:33750294 PRSS3 0.56 5.97 0.31 6.15e-9 Body mass index; CRC cis rs262150 0.851 rs2730249 chr7:158767628 A/G cg10570241 chr7:158785291 NA -0.51 -9.31 -0.46 1.92e-18 Facial morphology (factor 20); CRC cis rs4891159 0.527 rs34956524 chr18:74130480 A/G cg24786174 chr18:74118243 ZNF516 0.9 21.39 0.76 3.25e-64 Longevity; CRC cis rs853679 0.607 rs200489 chr6:27798257 T/C cg03623178 chr6:28175578 NA 0.78 6.63 0.34 1.36e-10 Depression; CRC cis rs798554 0.610 rs2251491 chr7:2852835 T/C cg17321639 chr7:2759063 NA -0.38 -5.84 -0.31 1.23e-8 Height; CRC cis rs7493 0.950 rs7785705 chr7:95033803 A/T cg04155289 chr7:94953770 PON1 -0.62 -7.79 -0.39 8.77e-14 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs7811142 0.943 rs28578163 chr7:100044754 A/G cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.06 15.37 0.65 1.54e-40 Platelet count; CRC cis rs55871839 0.684 rs13271523 chr8:59806664 T/C cg07426533 chr8:59803705 TOX -0.34 -6.05 -0.32 3.99e-9 Pneumonia; CRC trans rs10504229 0.817 rs114173899 chr8:58170640 G/T cg04077850 chr5:125800366 GRAMD3 0.37 6.09 0.32 3.12e-9 Developmental language disorder (linguistic errors); CRC cis rs1007738 0.507 rs61897857 chr11:47233458 G/A cg19486271 chr11:47235900 DDB2 0.42 5.78 0.3 1.7e-8 Bone mineral density (hip); CRC cis rs2115630 1.000 rs11854313 chr15:85304048 G/C cg09876464 chr15:85330779 ZNF592 0.45 7.52 0.38 5.13e-13 P wave terminal force; CRC cis rs11229555 0.609 rs34782543 chr11:58187398 G/A cg15696309 chr11:58395628 NA -0.82 -10.31 -0.49 8.59e-22 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; CRC cis rs7666738 0.800 rs7683737 chr4:99070880 A/T cg05340658 chr4:99064831 C4orf37 0.61 9.46 0.46 6.15e-19 Colonoscopy-negative controls vs population controls; CRC cis rs6674176 0.696 rs4448553 chr1:44411589 A/G cg15962314 chr1:44399869 ARTN 0.31 6.0 0.31 5.27e-9 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Cognitive ability; CRC cis rs8060686 0.920 rs1124324 chr16:67897487 C/T cg19582491 chr16:67682965 RLTPR -0.57 -6.9 -0.36 2.67e-11 HDL cholesterol;Metabolic syndrome; CRC cis rs798554 1.000 rs798554 chr7:2759795 C/T cg04166393 chr7:2884313 GNA12 0.47 6.44 0.33 4.2e-10 Height; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg02360337 chr11:65627185 MUS81;CFL1 0.45 6.33 0.33 7.83e-10 Intelligence (multi-trait analysis); CRC cis rs9811920 0.809 rs1384062 chr3:99597928 A/C cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G 0.4 5.7 0.3 2.6e-8 Axial length; CRC cis rs2948294 0.524 rs13270062 chr8:8112650 C/A cg08975724 chr8:8085496 FLJ10661 0.43 5.69 0.3 2.82e-8 Red cell distribution width; CRC cis rs6960043 0.764 rs7798124 chr7:15055616 A/G cg19272540 chr7:15055459 NA -0.23 -6.04 -0.32 4.26e-9 Type 2 diabetes; CRC cis rs28386778 0.897 rs9915552 chr17:61869095 G/A cg06873352 chr17:61820015 STRADA 0.8 15.32 0.65 2.36e-40 Prudent dietary pattern; CRC cis rs7043114 0.525 rs8067 chr9:95218829 G/T cg13798575 chr9:95087839 CENPP;NOL8 -0.4 -5.88 -0.31 1.02e-8 Height; CRC cis rs9303401 0.659 rs12935851 chr17:56600244 C/A cg10487724 chr17:56770010 TEX14;RAD51C 0.8 9.68 0.47 1.12e-19 Cognitive test performance; CRC cis rs8180040 0.676 rs7633698 chr3:47013452 A/T cg02527881 chr3:46936655 PTH1R -0.42 -7.96 -0.4 2.83e-14 Colorectal cancer; CRC cis rs4713118 0.547 rs2116981 chr6:28067951 T/G cg12172441 chr6:28176163 NA 0.62 7.33 0.37 1.76e-12 Parkinson's disease; CRC cis rs2739330 0.791 rs4822458 chr22:24265659 C/T cg11905131 chr22:24372483 LOC391322 -0.65 -10.26 -0.49 1.33e-21 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs9650315 0.530 rs7830138 chr8:57084125 A/G cg23139584 chr8:56987506 RPS20;SNORD54 0.44 6.4 0.33 5.39e-10 Height; CRC cis rs780094 0.544 rs780108 chr2:27684957 T/C cg24768116 chr2:27665128 KRTCAP3 -0.33 -7.5 -0.38 6.11e-13 Calcium levels;Fasting blood insulin;Metabolic traits;Triglyceride levels;Fasting plasma glucose;Urate levels in overweight individuals;Urate levels in obese individuals;Uric acid levels;Height;Age-related diseases, mortality and associated endophenotypes;Renal underexcretion gout;Fasting blood glucose (BMI interaction);Urate levels;Gondoic acid (20:1n-9) levels;Fasting blood insulin (BMI interaction);Triglycerides;Plasma omega-3 polyunsaturated fatty acid levels (docosapentaenoic acid);Type 2 diabetes;Nonalcoholic fatty liver disease;Hypertriglyceridemia;C-reactive protein;Age-related disease endophenotypes;LDL cholesterol;Metabolic syndrome;Crohn's disease;Alcohol consumption (drinks per week);Homeostasis model assessment of insulin resistance;Alcohol consumption;Red blood cell count;Fasting blood glucose; CRC trans rs4684776 0.548 rs17776719 chr3:11640481 A/G cg20302342 chr1:156215951 PAQR6 -0.48 -6.3 -0.33 9.8e-10 Small vessel stroke; CRC trans rs2303319 0.504 rs62189041 chr2:162599506 T/C cg25193742 chr10:104614220 C10orf32 -0.77 -6.51 -0.34 2.87e-10 Cognitive function; CRC cis rs7927592 0.956 rs12274114 chr11:68255577 A/C cg16797656 chr11:68205561 LRP5 0.39 6.21 0.32 1.59e-9 Total body bone mineral density; CRC cis rs7149337 0.805 rs2999361 chr14:51605358 G/A cg23942311 chr14:51606299 NA 0.82 17.2 0.69 9.75e-48 Cancer; CRC cis rs10504229 0.679 rs16921606 chr8:58034477 A/C cg22535103 chr8:58192502 C8orf71 -0.43 -5.92 -0.31 8.06e-9 Developmental language disorder (linguistic errors); CRC cis rs6681460 0.549 rs7547794 chr1:67031878 A/G cg02459107 chr1:67143332 SGIP1 0.34 5.63 0.3 3.78e-8 Presence of antiphospholipid antibodies; CRC cis rs7607369 0.536 rs7566656 chr2:219664519 A/G cg02176678 chr2:219576539 TTLL4 -0.39 -6.36 -0.33 6.91e-10 Red blood cell count;Amyotrophic lateral sclerosis; CRC cis rs12497850 1.000 rs10865952 chr3:48744484 A/G cg20833759 chr3:49053208 WDR6;DALRD3 0.43 7.37 0.38 1.42e-12 Parkinson's disease; CRC cis rs9733 0.519 rs3768005 chr1:150680988 A/T cg18016565 chr1:150552671 MCL1 0.48 6.94 0.36 2.04e-11 Tonsillectomy; CRC cis rs644799 0.965 rs3789960 chr11:95509037 C/G cg25622487 chr11:95524042 FAM76B;CEP57 0.75 11.51 0.54 5.3e-26 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs13202913 0.652 rs9371528 chr6:151832668 G/A cg10883421 chr6:151773342 RMND1;C6orf211 0.56 6.45 0.34 3.92e-10 Epstein-Barr virus copy number in lymphoblastoid cell lines; CRC cis rs2249625 0.508 rs60020363 chr6:72844706 C/T cg18830697 chr6:72922368 RIMS1 0.4 7.69 0.39 1.7e-13 Acute urticaria and angioedema (non-steroidal anti-inflammatory drug-induced); CRC cis rs8060686 0.591 rs80346622 chr16:68074419 C/T cg26727032 chr16:67993705 SLC12A4 -0.58 -6.49 -0.34 3.19e-10 HDL cholesterol;Metabolic syndrome; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg07165616 chr12:498868 KDM5A;CCDC77 0.53 6.86 0.35 3.39e-11 Thyroid stimulating hormone; CRC cis rs7772486 0.754 rs9497401 chr6:146051271 T/C cg13319975 chr6:146136371 FBXO30 0.45 6.58 0.34 1.84e-10 Lobe attachment (rater-scored or self-reported); CRC cis rs6921919 0.525 rs9468360 chr6:28344438 T/G cg21251018 chr6:28226885 NKAPL 0.39 6.02 0.31 4.74e-9 Autism spectrum disorder or schizophrenia; CRC trans rs17685 0.725 rs1044483 chr7:75659815 T/C cg19862616 chr7:65841803 NCRNA00174 -0.95 -17.4 -0.69 1.56e-48 Coffee consumption;Coffee consumption (cups per day); CRC cis rs10504229 0.511 rs75967910 chr8:58024231 C/G cg02290350 chr8:58132656 NA -0.55 -6.3 -0.33 9.68e-10 Developmental language disorder (linguistic errors); CRC trans rs8005150 0.737 rs56972319 chr14:88488089 G/A cg25527770 chr19:1444892 NA -0.57 -6.2 -0.32 1.67e-9 Hepatitis B; CRC cis rs12348691 0.503 rs894672 chr9:100612185 C/T cg13688889 chr9:100608707 NA -0.47 -6.03 -0.32 4.45e-9 Alopecia areata; CRC cis rs801193 0.967 rs2707849 chr7:66152712 T/C cg00343986 chr7:65444356 GUSB 0.49 7.18 0.37 4.67e-12 Aortic root size; CRC cis rs5758511 0.680 rs58654759 chr22:42642576 T/C cg00645731 chr22:42541494 CYP2D7P1 0.67 10.26 0.49 1.32e-21 Birth weight; CRC cis rs7833986 1.000 rs72654002 chr8:57095939 C/T cg23139584 chr8:56987506 RPS20;SNORD54 0.61 7.54 0.38 4.64e-13 Height; CRC cis rs17376456 0.877 rs2290937 chr5:93356515 A/T cg09848695 chr5:92956644 FAM172A;MIR2277 0.66 6.73 0.35 7.62e-11 Diabetic retinopathy; CRC cis rs11997175 0.545 rs67960786 chr8:33668770 G/A cg04338863 chr8:33670619 NA 0.41 6.74 0.35 7e-11 Body mass index; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg16720675 chr18:19284817 ABHD3 0.35 6.1 0.32 2.92e-9 Liver disease severity in Alagille syndrome; CRC trans rs113835537 0.627 rs4630309 chr11:66333072 A/C cg05030574 chr11:65189075 NEAT1 0.58 6.14 0.32 2.38e-9 Airway imaging phenotypes; CRC trans rs2727020 0.658 rs4980431 chr11:49350071 G/T cg21153622 chr11:89784906 NA -0.42 -6.94 -0.36 2.06e-11 Coronary artery disease; CRC cis rs873946 0.590 rs12783478 chr10:134550700 A/G cg18305652 chr10:134549665 INPP5A 0.53 7.75 0.39 1.13e-13 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg14358282 chr2:219866628 MIR375 0.38 6.02 0.31 4.55e-9 Liver disease severity in Alagille syndrome; CRC cis rs9648716 1.000 rs28529157 chr7:140614830 T/C cg10747023 chr7:140774559 NA 0.47 6.1 0.32 2.98e-9 Type 2 diabetes; CRC cis rs1005277 0.579 rs1740737 chr10:38499365 G/T cg25427524 chr10:38739819 LOC399744 -0.78 -13.86 -0.61 9.98e-35 Extrinsic epigenetic age acceleration; CRC cis rs1023500 0.573 rs133370 chr22:42465260 T/C cg11915388 chr22:42470451 FAM109B -0.41 -6.3 -0.33 9.81e-10 Schizophrenia; CRC cis rs6831352 0.801 rs2602897 chr4:100046293 A/T cg13256891 chr4:100009986 ADH5 0.66 8.89 0.44 4.04e-17 Alcohol dependence; CRC cis rs853679 0.517 rs9348793 chr6:28084189 G/A cg15845792 chr6:28175446 NA 1.0 13.1 0.59 7.81e-32 Depression; CRC cis rs9943753 0.508 rs2075433 chr12:109833920 A/G cg19025524 chr12:109796872 NA -0.53 -8.05 -0.41 1.56e-14 HDL cholesterol; CRC trans rs1814175 0.616 rs28417656 chr11:50040152 C/T cg03929089 chr4:120376271 NA -0.89 -16.04 -0.66 3.41e-43 Height; CRC cis rs13118159 0.556 rs4974615 chr4:1373551 A/G cg02018176 chr4:1364513 KIAA1530 -0.66 -11.43 -0.53 1.01e-25 Longevity; CRC cis rs1005277 0.579 rs2983343 chr10:38383332 A/G cg00409905 chr10:38381863 ZNF37A -0.68 -11.31 -0.53 2.89e-25 Extrinsic epigenetic age acceleration; CRC cis rs1707322 0.821 rs11211182 chr1:46240170 G/A cg03146154 chr1:46216737 IPP 0.64 9.02 0.45 1.57e-17 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs6076065 0.683 rs2424528 chr20:23361613 C/T cg11657817 chr20:23433608 CST11 0.45 6.79 0.35 5.39e-11 Facial morphology (factor 15, philtrum width); CRC cis rs7208859 0.673 rs2269915 chr17:29233344 C/T cg14008862 chr17:28927542 LRRC37B2 0.55 5.75 0.3 2.04e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs679087 1.000 rs679087 chr12:29917265 C/A cg14258853 chr12:29935411 TMTC1 -0.45 -7.62 -0.39 2.79e-13 Schizophrenia; CRC cis rs9916302 0.706 rs4795375 chr17:37662932 T/C cg00129232 chr17:37814104 STARD3 -0.58 -7.26 -0.37 2.74e-12 Glomerular filtration rate (creatinine); CRC cis rs644799 0.687 rs11021318 chr11:95522996 T/C cg25478527 chr11:95522999 CEP57;FAM76B 0.49 7.62 0.39 2.68e-13 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs17155006 0.655 rs437336 chr7:107728634 G/T cg05962710 chr7:107745446 LAMB4 -0.35 -5.85 -0.31 1.16e-8 Pneumococcal bacteremia; CRC cis rs1223397 0.938 rs9381884 chr6:13278788 A/G cg07912922 chr6:13274314 PHACTR1 0.48 5.99 0.31 5.59e-9 Blood pressure; CRC cis rs11098499 0.909 rs1546502 chr4:120235898 A/G cg09307838 chr4:120376055 NA 0.68 10.16 0.49 2.79e-21 Corneal astigmatism; CRC cis rs3823572 0.564 rs2953623 chr7:133659410 C/G cg03336402 chr7:133662267 EXOC4 -0.68 -10.78 -0.51 2.08e-23 Intelligence (multi-trait analysis); CRC cis rs12701220 0.604 rs12702122 chr7:1149494 C/G cg02733842 chr7:1102375 C7orf50 -0.66 -8.04 -0.41 1.62e-14 Bronchopulmonary dysplasia; CRC cis rs1552244 1.000 rs34179822 chr3:10140017 A/G cg10729496 chr3:10149963 C3orf24 0.49 6.78 0.35 5.57e-11 Alzheimer's disease; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg22228043 chr1:11159903 EXOSC10 0.43 6.31 0.33 9.1e-10 Response to antipsychotic treatment; CRC cis rs7937682 0.881 rs4936678 chr11:111625085 C/T cg19812747 chr11:111475976 SIK2 0.48 6.97 0.36 1.75e-11 Primary sclerosing cholangitis; CRC cis rs2637266 0.519 rs7923176 chr10:78298380 C/T cg18941641 chr10:78392320 NA 0.32 5.64 0.3 3.71e-8 Pulmonary function; CRC cis rs1862618 0.756 rs9292125 chr5:56107200 C/T cg18230493 chr5:56204884 C5orf35 -0.72 -9.2 -0.45 4.22e-18 Initial pursuit acceleration; CRC cis rs344364 0.602 rs12325217 chr16:1887108 A/T cg14074117 chr16:1909714 C16orf73 0.37 6.41 0.33 5.19e-10 Glomerular filtration rate in chronic kidney disease; CRC cis rs7618915 0.547 rs13069481 chr3:52666866 C/T cg05573699 chr3:52720067 GNL3;PBRM1 -0.46 -6.52 -0.34 2.59e-10 Bipolar disorder; CRC trans rs2303319 0.504 rs12467042 chr2:162526971 G/A cg12500891 chr11:57225987 NA -0.67 -6.12 -0.32 2.62e-9 Cognitive function; CRC cis rs6831352 0.760 rs2602859 chr4:100030583 G/A cg12011299 chr4:100065546 ADH4 0.49 9.26 0.45 2.63e-18 Alcohol dependence; CRC cis rs7552404 0.731 rs1689275 chr1:76409655 T/C cg10523679 chr1:76189770 ACADM -0.62 -7.8 -0.39 8.5e-14 Blood metabolite levels;Acylcarnitine levels; CRC cis rs10206020 0.885 rs13388254 chr2:1577209 A/G cg12573674 chr2:1569213 NA -0.78 -10.53 -0.5 1.54e-22 IgG glycosylation; CRC cis rs7584330 0.518 rs113812061 chr2:238447934 T/C cg14458575 chr2:238380390 NA 0.65 8.1 0.41 1.11e-14 Prostate cancer; CRC cis rs7412746 0.611 rs11204747 chr1:150927152 A/G cg15448220 chr1:150897856 SETDB1 -0.47 -6.89 -0.35 2.9e-11 Melanoma; CRC cis rs2797160 1.000 rs2211419 chr6:125995533 C/T cg05901451 chr6:126070800 HEY2 0.38 5.89 0.31 9.58e-9 Endometrial cancer; CRC cis rs9534288 0.797 rs6561278 chr13:46572937 T/C cg15192986 chr13:46630673 CPB2 -0.67 -9.85 -0.48 3.16e-20 Blood protein levels; CRC cis rs73200209 0.662 rs17426872 chr12:116636915 T/C cg01776926 chr12:116560359 MED13L -0.6 -6.97 -0.36 1.75e-11 Total body bone mineral density; CRC cis rs2576037 0.583 rs11660085 chr18:44529603 A/G cg20875182 chr18:44561130 TCEB3B;KATNAL2 -0.68 -11.56 -0.54 3.48e-26 Personality dimensions; CRC trans rs12599106 0.660 rs12919333 chr16:34991336 C/T cg18110333 chr6:292329 DUSP22 -0.7 -10.24 -0.49 1.49e-21 Menopause (age at onset); CRC cis rs7833986 0.501 rs2719257 chr8:56940173 A/G cg23139584 chr8:56987506 RPS20;SNORD54 0.91 12.63 0.57 4.47e-30 Height; CRC cis rs12044355 0.858 rs1538975 chr1:231828372 C/T cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX 0.5 6.81 0.35 4.7e-11 Alzheimer's disease; CRC cis rs1506636 1.000 rs684548 chr7:123397102 A/T cg03229431 chr7:123269106 ASB15 0.73 11.51 0.54 5.61e-26 Plateletcrit;Platelet count; CRC cis rs13108904 0.901 rs7668661 chr4:1300172 A/G cg16405210 chr4:1374714 KIAA1530 -0.42 -6.07 -0.32 3.5e-9 Obesity-related traits; CRC cis rs7020830 0.894 rs13300951 chr9:37146627 A/G cg14294708 chr9:37120828 ZCCHC7 1.21 28.03 0.84 3.43e-89 Schizophrenia; CRC cis rs801193 1.000 rs11773829 chr7:66141074 G/A cg25985355 chr7:65971099 NA 0.33 5.74 0.3 2.15e-8 Aortic root size; CRC cis rs2070488 0.965 rs1046048 chr3:38524742 C/T cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.92 17.31 0.69 3.51e-48 Electrocardiographic conduction measures; CRC cis rs7512552 0.839 rs696616 chr1:150336173 G/A cg15654264 chr1:150340011 RPRD2 0.6 8.49 0.42 7.05e-16 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); CRC cis rs13144136 0.748 rs4697773 chr4:10668379 C/T cg10242279 chr4:10666415 CLNK -0.33 -5.67 -0.3 3.07e-8 Resistance to antihypertensive treatment in hypertension; CRC cis rs7849270 1.000 rs3739847 chr9:131911574 A/G cg13538475 chr9:131942899 NA 0.32 6.25 0.33 1.28e-9 Blood metabolite ratios; CRC cis rs7223966 1.000 rs16947014 chr17:61719032 C/T cg23090583 chr17:61904693 PSMC5;FTSJ3 0.47 5.92 0.31 7.91e-9 Hip circumference adjusted for BMI;Body mass index; CRC cis rs72615157 0.634 rs74742883 chr7:99785765 T/G cg07160278 chr7:100027354 MEPCE;ZCWPW1 0.72 8.63 0.43 2.75e-16 Lung function (FEV1/FVC); CRC cis rs6761276 0.899 rs11677043 chr2:113835520 A/G cg09040174 chr2:113837401 NA 0.67 10.7 0.51 4.04e-23 Protein quantitative trait loci; CRC trans rs11252926 0.527 rs10904093 chr10:436848 A/G cg00953403 chr17:74099816 EXOC7 -0.47 -6.94 -0.36 2.05e-11 Psychosis in Alzheimer's disease; CRC cis rs9467711 0.524 rs13216484 chr6:26762087 C/T cg12315302 chr6:26189340 HIST1H4D 0.96 6.62 0.34 1.43e-10 Autism spectrum disorder or schizophrenia; CRC trans rs11026407 0.967 rs7127246 chr11:22060228 C/G cg20850243 chr13:99229849 STK24 -0.6 -6.3 -0.33 9.5e-10 Plasma thyroid-stimulating hormone levels; CRC cis rs262150 0.837 rs2657404 chr7:158783155 C/T cg19418458 chr7:158789849 NA -0.43 -7.19 -0.37 4.34e-12 Facial morphology (factor 20); CRC cis rs270601 0.913 rs273916 chr5:131659830 C/A cg18758796 chr5:131593413 PDLIM4 0.4 6.37 0.33 6.42e-10 Acylcarnitine levels; CRC cis rs713477 0.935 rs12888181 chr14:55906082 A/C cg13175173 chr14:55914753 NA -0.53 -9.94 -0.48 1.62e-20 Pediatric bone mineral content (femoral neck); CRC cis rs59918340 0.764 rs2304282 chr8:142229543 A/G cg03316587 chr8:142245164 NA -0.38 -5.74 -0.3 2.15e-8 Immature fraction of reticulocytes; CRC cis rs6951245 1.000 rs74369356 chr7:1071711 T/C cg04025307 chr7:1156635 C7orf50 0.63 6.63 0.34 1.41e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs7258465 1.000 rs4808801 chr19:18571141 A/G cg06953865 chr19:18549723 ISYNA1 -0.39 -5.85 -0.31 1.19e-8 Breast cancer; CRC cis rs172166 0.637 rs1225592 chr6:28150242 G/A cg03623178 chr6:28175578 NA 0.84 13.06 0.58 1.07e-31 Cardiac Troponin-T levels; CRC cis rs6762 0.748 rs1130719 chr11:838760 T/A cg15787769 chr11:842744 TSPAN4;POLR2L -0.47 -6.65 -0.34 1.24e-10 Mean platelet volume; CRC cis rs7659604 1.000 rs6823488 chr4:122664819 A/G cg20573242 chr4:122745356 CCNA2 0.39 5.64 0.3 3.65e-8 Type 2 diabetes; CRC cis rs9902453 0.817 rs2617880 chr17:28106118 A/G cg26525008 chr17:28256777 EFCAB5;SSH2 -0.58 -8.74 -0.43 1.22e-16 Coffee consumption (cups per day); CRC cis rs56399783 0.614 rs73047368 chr7:2766396 G/T cg19731401 chr7:2775893 GNA12 0.69 7.22 0.37 3.73e-12 Childhood ear infection; CRC cis rs9611519 0.780 rs9611528 chr22:41648502 T/C cg06634786 chr22:41940651 POLR3H -0.43 -5.85 -0.31 1.19e-8 Neuroticism; CRC cis rs4862750 0.872 rs7672831 chr4:187898882 C/T cg22105103 chr4:187893119 NA 0.63 11.69 0.54 1.18e-26 Lobe attachment (rater-scored or self-reported); CRC cis rs4713118 0.513 rs149972 chr6:27983227 C/T cg03623178 chr6:28175578 NA 0.79 11.81 0.55 4.51e-27 Parkinson's disease; CRC cis rs995000 0.931 rs11207996 chr1:63055470 G/A cg19896129 chr1:63156450 NA 0.39 5.66 0.3 3.32e-8 Triglyceride levels; CRC cis rs12476592 0.602 rs2421952 chr2:63749833 T/C cg10828910 chr2:63850056 LOC388955 0.5 6.19 0.32 1.78e-9 Childhood ear infection; CRC cis rs10504229 0.595 rs77615399 chr8:58117394 C/G cg04204079 chr8:58130323 NA -0.45 -5.78 -0.3 1.71e-8 Developmental language disorder (linguistic errors); CRC cis rs5769707 0.967 rs1018812 chr22:50010073 C/T cg05373962 chr22:49881684 NA -0.39 -7.4 -0.38 1.16e-12 Monocyte count;Monocyte percentage of white cells; CRC trans rs2727020 0.521 rs937430 chr11:49542457 A/G cg11707556 chr5:10655725 ANKRD33B 0.47 7.59 0.39 3.33e-13 Coronary artery disease; CRC cis rs7149337 0.933 rs28705789 chr14:51713508 C/T cg23942311 chr14:51606299 NA 0.65 11.14 0.52 1.11e-24 Cancer; CRC cis rs9302065 0.565 rs2992908 chr13:95960600 G/A cg24476569 chr13:95954382 ABCC4 -0.37 -5.61 -0.3 4.34e-8 Blood metabolite levels; CRC cis rs7945705 0.902 rs2012696 chr11:8995818 A/C cg14711859 chr11:8959438 ASCL3 -0.45 -7.13 -0.37 6.38e-12 Hemoglobin concentration; CRC cis rs2282802 0.685 rs10051345 chr5:139670932 C/G cg26211634 chr5:139558579 C5orf32 -0.44 -7.63 -0.39 2.51e-13 Intelligence (multi-trait analysis); CRC cis rs10971721 0.822 rs72727344 chr9:33939120 C/G cg13495928 chr9:33750294 PRSS3 0.56 5.95 0.31 6.96e-9 Body mass index; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg24506662 chr3:129830295 LOC729375 0.48 6.49 0.34 3.21e-10 Anxiety disorder; CRC cis rs10464366 0.544 rs12701697 chr7:39182165 C/T cg15212455 chr7:39170539 POU6F2 0.5 6.56 0.34 2.03e-10 IgG glycosylation; CRC cis rs17065868 0.649 rs9533848 chr13:45005713 C/T cg10246903 chr13:45222710 NA -0.51 -5.82 -0.31 1.42e-8 Antineutrophil cytoplasmic antibody-associated vasculitis; CRC cis rs6831352 0.918 rs7670060 chr4:100059568 G/T cg13256891 chr4:100009986 ADH5 -0.65 -8.72 -0.43 1.42e-16 Alcohol dependence; CRC cis rs10886503 0.614 rs3009908 chr10:121262900 T/C cg17804342 chr10:121271663 RGS10 -0.82 -7.77 -0.39 1.03e-13 Obstetric antiphospholipid syndrome; CRC cis rs2842992 1.000 rs2842992 chr6:160071159 G/A cg11366901 chr6:160182831 ACAT2 0.8 11.39 0.53 1.42e-25 Age-related macular degeneration (geographic atrophy); CRC cis rs4588572 0.644 rs2241566 chr5:77784738 C/T cg11446398 chr5:77624930 NA -0.41 -5.81 -0.3 1.5e-8 Triglycerides; CRC trans rs6076960 0.684 rs6054055 chr20:6257517 C/G cg17788362 chr6:86352627 SYNCRIP 0.54 7.52 0.38 5.33e-13 Smooth-surface caries; CRC cis rs847577 0.748 rs940431 chr7:97716495 C/T cg24562669 chr7:97807699 LMTK2 0.76 16.49 0.67 5.94e-45 Breast cancer; CRC cis rs262150 0.644 rs2730228 chr7:158789361 T/C cg19418458 chr7:158789849 NA -0.51 -8.8 -0.44 7.72e-17 Facial morphology (factor 20); CRC cis rs9901225 1 rs9901225 chr17:40755811 C/T cg21433558 chr17:40837037 CNTNAP1 0.48 7.64 0.39 2.38e-13 Colorectal or endometrial cancer; CRC cis rs55788414 0.527 rs2873368 chr16:81184208 C/G cg06400318 chr16:81190750 PKD1L2 -0.59 -6.76 -0.35 6.2e-11 Left ventricular obstructive tract defect (maternal effect); CRC cis rs947211 0.750 rs5014255 chr1:205753870 C/A cg07167872 chr1:205819463 PM20D1 0.42 5.86 0.31 1.12e-8 Parkinson's disease; CRC cis rs6952808 0.771 rs10244946 chr7:1921068 A/G cg02951883 chr7:2050386 MAD1L1 0.62 10.25 0.49 1.36e-21 Bipolar disorder and schizophrenia; CRC cis rs12505749 0.542 rs6849183 chr4:57329936 C/T cg04528060 chr4:57371868 ARL9 0.54 5.75 0.3 2.09e-8 Airflow obstruction; CRC cis rs12477438 0.520 rs2309581 chr2:99784292 A/G cg26064155 chr2:99771622 LIPT1;TSGA10 -0.85 -15.18 -0.64 8.11e-40 Chronic sinus infection; CRC cis rs7705042 0.826 rs6883827 chr5:141504991 A/G cg07392085 chr5:141489673 NDFIP1 0.46 7.22 0.37 3.57e-12 Asthma; CRC cis rs10504229 0.600 rs6987243 chr8:58115406 T/C cg02725872 chr8:58115012 NA -0.64 -11.55 -0.54 3.85e-26 Developmental language disorder (linguistic errors); CRC cis rs35110281 0.776 rs2838338 chr21:45075582 T/C cg04455712 chr21:45112962 RRP1B 0.41 8.01 0.4 1.97e-14 Mean corpuscular volume; CRC cis rs6424115 0.830 rs2229584 chr1:24200969 T/C cg10978503 chr1:24200527 CNR2 0.61 11.06 0.52 2.22e-24 Immature fraction of reticulocytes; CRC cis rs6942756 1.000 rs2402945 chr7:128956256 C/A cg02491457 chr7:128862824 NA -0.75 -10.19 -0.49 2.26e-21 White matter hyperintensity burden; CRC trans rs12310956 0.532 rs7306007 chr12:33975209 C/G cg26384229 chr12:38710491 ALG10B 0.47 6.34 0.33 7.69e-10 Morning vs. evening chronotype; CRC cis rs2836974 0.644 rs61300849 chr21:40680194 G/A cg17971929 chr21:40555470 PSMG1 -0.7 -10.62 -0.51 7.33e-23 Cognitive function; CRC cis rs2549003 1.000 rs2070725 chr5:131821788 C/T cg02551604 chr5:131831745 NA -0.54 -8.34 -0.42 2e-15 Asthma (sex interaction); CRC cis rs6662572 0.703 rs10789482 chr1:46396704 G/A cg08644498 chr1:46502608 NA -0.45 -7.08 -0.36 8.76e-12 Blood protein levels; CRC cis rs9916302 0.706 rs6503521 chr17:37715551 A/C cg00129232 chr17:37814104 STARD3 0.62 7.14 0.37 6.19e-12 Glomerular filtration rate (creatinine); CRC cis rs4665809 0.590 rs6730317 chr2:26419482 C/T cg22920501 chr2:26401640 FAM59B -0.84 -12.02 -0.55 7.45e-28 Gut microbiome composition (summer); CRC cis rs6694270 0.529 rs12565650 chr1:19108355 G/A cg26220594 chr1:19110978 NA -0.47 -6.47 -0.34 3.56e-10 Drug-induced liver injury (nitrofurantoin); CRC cis rs4713118 0.869 rs9283881 chr6:27715255 A/T cg15845792 chr6:28175446 NA 0.66 9.22 0.45 3.55e-18 Parkinson's disease; CRC cis rs79839061 0.610 rs78590562 chr4:869715 C/T cg14530993 chr4:882597 GAK 0.82 7.82 0.4 7.42e-14 Intelligence (multi-trait analysis); CRC trans rs4942242 1.000 rs9533566 chr13:44224691 T/C cg19169023 chr15:41853346 TYRO3 -0.51 -7.77 -0.39 1.04e-13 Response to tocilizumab in rheumatoid arthritis; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg03670153 chr3:184079754 CLCN2;POLR2H 0.47 6.69 0.35 9.55e-11 Response to antipsychotic treatment; CRC cis rs7044106 0.791 rs10984994 chr9:123478769 A/T cg09586646 chr9:123605570 PSMD5;LOC253039 -0.61 -8.62 -0.43 2.91e-16 Hip circumference adjusted for BMI; CRC cis rs1691799 0.831 rs6581678 chr12:66776656 A/G cg16791601 chr12:66731901 HELB -0.62 -10.62 -0.51 7.67e-23 White blood cell count (basophil); CRC cis rs2735413 0.918 rs12924772 chr16:78083115 T/C cg04733911 chr16:78082701 NA -0.45 -7.41 -0.38 1.11e-12 Systolic blood pressure (alcohol consumption interaction); CRC cis rs9463078 0.764 rs9369516 chr6:44833598 C/T cg25276700 chr6:44698697 NA -0.28 -6.72 -0.35 7.84e-11 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; CRC cis rs16973500 0.808 rs112121746 chr16:71874983 G/A cg00732059 chr16:71740210 PHLPP2 -0.7 -7.14 -0.37 6.01e-12 Response to anti-TNF therapy in rheumatoid arthritis;Attention deficit hyperactivity disorder and conduct disorder; CRC cis rs7149337 0.933 rs28705789 chr14:51713508 C/T cg18683604 chr14:51561293 TRIM9 0.31 6.08 0.32 3.32e-9 Cancer; CRC cis rs9487051 0.735 rs882074 chr6:109611720 C/T cg21918786 chr6:109611834 NA -0.44 -8.12 -0.41 9.71e-15 Reticulocyte fraction of red cells; CRC cis rs2839186 0.587 rs35679325 chr21:47640980 A/G cg26721908 chr21:47610096 LSS 0.41 6.26 0.33 1.22e-9 Testicular germ cell tumor; CRC cis rs55883249 1.000 rs62119429 chr2:9743585 G/C cg23886495 chr2:9695866 ADAM17 0.5 5.78 0.3 1.78e-8 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; CRC cis rs9322193 0.607 rs4870078 chr6:150201812 A/G cg07701084 chr6:150067640 NUP43 -0.47 -5.74 -0.3 2.16e-8 Lung cancer; CRC cis rs6141769 0.542 rs6058846 chr20:31324035 A/C cg13636640 chr20:31349939 DNMT3B -0.43 -6.14 -0.32 2.37e-9 Subjective well-being; CRC cis rs1348850 0.561 rs1838890 chr2:178410938 C/A cg27490568 chr2:178487706 NA 0.61 7.32 0.37 1.89e-12 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs826838 1.000 rs826891 chr12:39100824 A/G cg13010199 chr12:38710504 ALG10B -0.4 -6.04 -0.32 4.27e-9 Heart rate; CRC cis rs1018836 0.892 rs5005585 chr8:91581975 A/G cg16814680 chr8:91681699 NA -0.59 -9.1 -0.45 9.01e-18 Ejection fraction in Tripanosoma cruzi seropositivity; CRC cis rs524281 0.861 rs485857 chr11:65959519 A/G cg16950941 chr11:66035639 RAB1B -0.57 -7.26 -0.37 2.78e-12 Electroencephalogram traits; CRC cis rs4727027 0.866 rs2373438 chr7:148780287 C/A cg12479418 chr7:148823350 ZNF425;ZNF398 0.44 5.94 0.31 7.11e-9 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC cis rs4713118 0.513 rs149951 chr6:28033087 T/C cg06470822 chr6:28175283 NA 0.8 12.0 0.55 9.26e-28 Parkinson's disease; CRC cis rs10256972 0.521 rs871019 chr7:1105230 A/G cg03188948 chr7:1209495 NA 0.39 5.91 0.31 8.43e-9 Longevity;Endometriosis; CRC trans rs10021731 0.718 rs2219591 chr4:115413058 G/T cg25927708 chr2:119603813 EN1 -0.33 -6.01 -0.31 4.92e-9 Optic disc area; CRC cis rs7615952 0.576 rs66671308 chr3:125793526 T/G cg04553112 chr3:125709451 NA -0.51 -5.99 -0.31 5.55e-9 Blood pressure (smoking interaction); CRC cis rs11098499 0.754 rs10212714 chr4:120254302 T/C cg09307838 chr4:120376055 NA 0.6 9.11 0.45 8.37e-18 Corneal astigmatism; CRC cis rs2228479 0.702 rs12600047 chr16:89831630 G/A cg06656553 chr16:89960601 TCF25 -0.73 -5.99 -0.31 5.48e-9 Skin colour saturation; CRC cis rs10504229 0.775 rs56155911 chr8:58163247 C/T cg22535103 chr8:58192502 C8orf71 -0.72 -8.51 -0.42 6.25e-16 Developmental language disorder (linguistic errors); CRC cis rs7937682 0.924 rs489783 chr11:111520522 A/G cg09085632 chr11:111637200 PPP2R1B -0.99 -19.28 -0.73 5.84e-56 Primary sclerosing cholangitis; CRC trans rs5756813 0.754 rs4820308 chr22:38176216 G/A cg19894588 chr14:64061835 NA -0.54 -7.2 -0.37 4.07e-12 Optic cup area;Vertical cup-disc ratio; CRC trans rs2885056 0.783 rs12459941 chr19:10666112 A/G cg01878214 chr7:45145334 TBRG4;SNORA5C;SNORA5A -0.44 -5.99 -0.31 5.41e-9 Red cell distribution width; CRC cis rs7909074 0.966 rs879074 chr10:45400053 G/A cg04218760 chr10:45406644 TMEM72 -0.34 -9.21 -0.45 3.8e-18 Mean corpuscular volume; CRC cis rs34172651 0.917 rs11640931 chr16:24797919 A/G cg06028605 chr16:24865363 SLC5A11 0.39 7.26 0.37 2.9e-12 Intelligence (multi-trait analysis); CRC cis rs9457247 0.624 rs9457260 chr6:167466665 C/T cg07741184 chr6:167504864 NA 0.44 7.42 0.38 1.02e-12 Crohn's disease; CRC cis rs2617583 0.509 rs10630 chr5:1462720 G/A cg07148919 chr5:1466943 LPCAT1 -0.43 -5.68 -0.3 2.96e-8 Breast cancer; CRC cis rs1552244 0.572 rs73117481 chr3:10160132 C/T cg02579736 chr3:10068473 FANCD2;CIDECP 1.01 11.58 0.54 2.98e-26 Alzheimer's disease; CRC cis rs7945705 0.967 rs56316046 chr11:8876598 G/T cg14711859 chr11:8959438 ASCL3 -0.52 -8.48 -0.42 7.61e-16 Hemoglobin concentration; CRC cis rs11155671 0.530 rs9397420 chr6:150206781 C/T cg07701084 chr6:150067640 NUP43 -0.47 -6.91 -0.36 2.58e-11 Testicular germ cell tumor; CRC cis rs7927592 0.913 rs11228268 chr11:68287447 A/T cg16797656 chr11:68205561 LRP5 0.37 5.85 0.31 1.18e-8 Total body bone mineral density; CRC cis rs367615 0.552 rs2963010 chr5:108737043 T/C cg17395555 chr5:108820864 NA -0.36 -6.82 -0.35 4.25e-11 Colorectal cancer (SNP x SNP interaction); CRC cis rs1552244 0.938 rs56274701 chr3:10167790 G/A cg02579736 chr3:10068473 FANCD2;CIDECP 1.01 13.32 0.59 1.17e-32 Alzheimer's disease; CRC cis rs116979167 0.545 rs1706914 chr7:105196445 A/T cg02135003 chr7:105160482 PUS7 -0.52 -8.07 -0.41 1.32e-14 Bipolar disorder (body mass index interaction); CRC cis rs6088590 1.000 rs11696546 chr20:33452999 C/G cg08999081 chr20:33150536 PIGU 0.48 7.97 0.4 2.72e-14 Coronary artery disease; CRC cis rs747650 0.504 rs61896133 chr11:47115719 G/C cg19486271 chr11:47235900 DDB2 0.44 5.89 0.31 9.76e-9 Acne (severe); CRC cis rs6502050 0.842 rs7218075 chr17:80076808 C/G cg22110888 chr17:80059540 CCDC57 -0.42 -6.62 -0.34 1.48e-10 Life satisfaction; CRC cis rs7927771 1.000 rs12418852 chr11:47868853 C/G cg20307385 chr11:47447363 PSMC3 -0.49 -6.58 -0.34 1.89e-10 Subjective well-being; CRC trans rs2303319 0.504 rs72877343 chr2:162607487 A/C cg27342122 chr8:133787442 PHF20L1 -0.72 -6.12 -0.32 2.68e-9 Cognitive function; CRC cis rs11105298 0.891 rs10858909 chr12:89935387 C/T cg00757033 chr12:89920650 WDR51B 0.38 6.25 0.33 1.28e-9 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; CRC cis rs6754311 0.773 rs309180 chr2:136614255 A/G cg25344623 chr2:136566232 LCT -0.33 -6.15 -0.32 2.24e-9 Mosquito bite size; CRC cis rs7412746 0.658 rs10305711 chr1:150802996 T/C cg15448220 chr1:150897856 SETDB1 0.57 8.22 0.41 4.63e-15 Melanoma; CRC trans rs7618501 0.521 rs3796386 chr3:49899795 G/A cg21659725 chr3:3221576 CRBN 0.52 7.75 0.39 1.14e-13 Intelligence (multi-trait analysis); CRC cis rs877282 0.853 rs12763400 chr10:763617 C/T cg06581033 chr10:766294 NA -0.52 -5.78 -0.3 1.71e-8 Uric acid levels; CRC cis rs72781680 0.611 rs72797819 chr2:24351141 T/G cg06627628 chr2:24431161 ITSN2 -0.54 -6.3 -0.33 9.34e-10 Lymphocyte counts; CRC cis rs367943 0.712 rs6867397 chr5:112725759 C/T cg12552261 chr5:112820674 MCC -0.35 -5.73 -0.3 2.26e-8 Type 2 diabetes; CRC cis rs4819052 1.000 rs13053002 chr21:46677854 C/T cg19498844 chr21:46707878 POFUT2;LOC642852 0.84 11.21 0.53 6.57e-25 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg06207460 chr9:4741011 AK3 0.5 7.95 0.4 3.03e-14 Liver disease severity in Alagille syndrome; CRC cis rs1322512 1.000 rs2758784 chr6:153010489 A/G cg03415253 chr6:152958462 SYNE1 0.4 6.04 0.32 4.14e-9 Tonometry; CRC cis rs6502050 0.799 rs8066370 chr17:80102105 T/C cg25804541 chr17:80189381 SLC16A3 -0.31 -5.97 -0.31 6.08e-9 Life satisfaction; CRC cis rs12291225 0.679 rs11023178 chr11:14310282 G/A cg05501817 chr11:14380813 RRAS2 -0.46 -6.12 -0.32 2.61e-9 Sense of smell; CRC trans rs1656966 1.000 rs1656966 chr3:186466252 C/T cg10821925 chr12:29533733 ERGIC2 0.41 6.12 0.32 2.62e-9 Myopia (pathological); CRC cis rs4665809 1.000 rs12471809 chr2:26307140 A/G cg22920501 chr2:26401640 FAM59B -0.53 -7.09 -0.36 8.01e-12 Gut microbiome composition (summer); CRC cis rs1670533 1.000 rs6837145 chr4:1071067 T/C cg27284194 chr4:1044797 NA 0.5 6.48 0.34 3.42e-10 Recombination rate (females); CRC cis rs2732480 0.500 rs12828309 chr12:48641160 C/T cg24011408 chr12:48396354 COL2A1 0.45 6.38 0.33 6.14e-10 Hemoglobin concentration;Red blood cell count;Hematocrit; CRC cis rs4919694 1.000 rs12253284 chr10:104665145 G/C cg04362960 chr10:104952993 NT5C2 1.05 9.84 0.48 3.29e-20 Arsenic metabolism; CRC cis rs10504229 0.562 rs2014516 chr8:58128288 C/A cg04204079 chr8:58130323 NA -0.45 -5.78 -0.3 1.71e-8 Developmental language disorder (linguistic errors); CRC cis rs754466 0.605 rs10824578 chr10:79578244 G/C cg17075019 chr10:79541650 NA -0.98 -19.62 -0.73 2.67e-57 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs1552244 0.572 rs7645759 chr3:10157368 C/T cg02579736 chr3:10068473 FANCD2;CIDECP 1.01 11.41 0.53 1.25e-25 Alzheimer's disease; CRC cis rs2462686 0.965 rs1525831 chr7:45994409 C/T cg23193639 chr7:45961078 IGFBP3 0.37 5.94 0.31 7.4e-9 Major depressive disorder; CRC cis rs11212617 0.935 rs227070 chr11:108211412 T/G cg14761454 chr11:108092087 ATM;NPAT 0.39 5.66 0.3 3.22e-8 Response to metformin in type 2 diabetes (glycemic); CRC cis rs7618501 0.633 rs2526748 chr3:50080439 A/G cg24110177 chr3:50126178 RBM5 0.51 7.98 0.4 2.48e-14 Intelligence (multi-trait analysis); CRC trans rs17685 0.672 rs56343450 chr7:75796235 C/T cg19862616 chr7:65841803 NCRNA00174 0.97 16.87 0.68 1.91e-46 Coffee consumption;Coffee consumption (cups per day); CRC cis rs394563 0.726 rs6942381 chr6:149662991 G/C cg03678062 chr6:149772716 ZC3H12D 0.36 6.57 0.34 1.93e-10 Dupuytren's disease; CRC cis rs7849270 1.000 rs10988224 chr9:131903334 A/T cg13538475 chr9:131942899 NA -0.29 -5.77 -0.3 1.78e-8 Blood metabolite ratios; CRC cis rs9462027 0.540 rs9366863 chr6:34688946 T/C cg07306190 chr6:34760872 UHRF1BP1 0.34 6.07 0.32 3.49e-9 Systemic lupus erythematosus; CRC cis rs7927771 1.000 rs1317149 chr11:47486885 C/T cg18512352 chr11:47633146 NA -0.48 -9.41 -0.46 8.9e-19 Subjective well-being; CRC cis rs12701220 0.553 rs9639882 chr7:1133731 G/A cg00990874 chr7:1149470 C7orf50 -0.68 -8.89 -0.44 4.1e-17 Bronchopulmonary dysplasia; CRC cis rs8062405 1.000 rs55991577 chr16:28843025 C/T cg08761264 chr16:28874980 SH2B1 -0.42 -5.63 -0.3 3.83e-8 Cognitive ability (multi-trait analysis);Cognitive ability; CRC cis rs6952808 0.929 rs12667688 chr7:1931030 C/T cg14004847 chr7:1930337 MAD1L1 -0.43 -5.68 -0.3 3.02e-8 Bipolar disorder and schizophrenia; CRC trans rs16846053 0.786 rs72873645 chr2:162495047 G/A cg27113153 chr11:123612418 ZNF202 -0.68 -6.06 -0.32 3.72e-9 Blood osmolality (transformed sodium); CRC cis rs1568889 1.000 rs16917735 chr11:28119980 A/T cg06544937 chr11:28130018 METT5D1;KIF18A -0.78 -10.75 -0.51 2.59e-23 Bipolar disorder; CRC cis rs1401999 1.000 rs7632670 chr3:183713877 A/G cg20387954 chr3:183756860 HTR3D 0.45 7.72 0.39 1.45e-13 Anterior chamber depth; CRC cis rs34779708 0.931 rs1926556 chr10:35344907 T/C cg03585969 chr10:35415529 CREM 0.65 8.64 0.43 2.46e-16 Inflammatory bowel disease;Crohn's disease; CRC cis rs713477 1.000 rs8010013 chr14:55884828 A/C cg13175173 chr14:55914753 NA -0.48 -8.81 -0.44 7.32e-17 Pediatric bone mineral content (femoral neck); CRC trans rs8073060 0.586 rs225286 chr17:33930458 G/A cg19694781 chr19:47549865 TMEM160 -1.04 -14.44 -0.62 6.2e-37 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; CRC cis rs9682041 0.866 rs6444926 chr3:170133235 T/C cg11886554 chr3:170076028 SKIL 1.06 11.32 0.53 2.52e-25 Glomerular filtration rate in non diabetics (creatinine);Glomerular filtration rate (creatinine); CRC cis rs651907 0.557 rs1056579 chr3:101397877 T/G cg12386194 chr3:101231763 SENP7 0.49 7.11 0.36 7.34e-12 Colorectal cancer; CRC cis rs6604026 0.922 rs7521417 chr1:93377835 C/T cg22128645 chr1:93425802 FAM69A -0.41 -5.9 -0.31 9.23e-9 Multiple sclerosis; CRC cis rs6662572 1.000 rs72688452 chr1:46092365 G/A cg03123370 chr1:45965343 CCDC163P;MMACHC 0.49 5.86 0.31 1.1e-8 Blood protein levels; CRC cis rs9611565 0.921 rs2281332 chr22:41746212 T/C cg06634786 chr22:41940651 POLR3H -0.41 -5.81 -0.31 1.45e-8 Vitiligo; CRC cis rs1865760 0.566 rs9467672 chr6:26083904 C/T cg18357526 chr6:26021779 HIST1H4A 0.41 5.83 0.31 1.32e-8 Height; CRC cis rs2535633 0.588 rs2564930 chr3:53017307 T/C cg11645453 chr3:52864694 ITIH4 -0.45 -8.6 -0.43 3.37e-16 Body mass index; CRC cis rs11229555 1.000 rs12808544 chr11:58373221 C/A cg15696309 chr11:58395628 NA -0.95 -13.36 -0.59 7.99e-33 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; CRC cis rs7615952 0.576 rs4646763 chr3:125822129 G/A cg06494592 chr3:125709126 NA -0.57 -6.79 -0.35 5.14e-11 Blood pressure (smoking interaction); CRC cis rs853679 0.517 rs9348794 chr6:28117757 T/A cg02631126 chr6:28058918 ZSCAN12L1 0.29 5.91 0.31 8.38e-9 Depression; CRC cis rs681343 1.000 rs516246 chr19:49206172 C/T cg21064579 chr19:49206444 FUT2 0.52 9.13 0.45 7.05e-18 Lung adenocarcinoma;Primary sclerosing cholangitis;Childhood ear infection; CRC cis rs7617773 0.746 rs4130995 chr3:48358255 C/T cg11946769 chr3:48343235 NME6 0.58 8.27 0.41 3.32e-15 Coronary artery disease; CRC cis rs2949837 0.603 rs1542818 chr7:45977656 G/T cg21268650 chr7:45961089 IGFBP3 0.38 6.41 0.33 5.05e-10 Sitting height ratio; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg10955293 chr1:24117561 LYPLA2 0.43 5.98 0.31 5.96e-9 Anxiety disorder; CRC cis rs798554 0.723 rs798518 chr7:2777825 A/G cg13628971 chr7:2884303 GNA12 0.55 7.87 0.4 5.3e-14 Height; CRC cis rs10504229 1.000 rs67384205 chr8:58180348 C/G cg02725872 chr8:58115012 NA -0.38 -6.43 -0.33 4.44e-10 Developmental language disorder (linguistic errors); CRC cis rs7572644 0.640 rs12617113 chr2:28059937 A/G cg27432699 chr2:27873401 GPN1 0.47 6.24 0.33 1.36e-9 Response to carboplatin and paclitaxel in ovarian cancer (Caspase 3/7 EC50); CRC cis rs1707322 1.000 rs6687301 chr1:46382852 T/C cg03146154 chr1:46216737 IPP 0.51 7.16 0.37 5.32e-12 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg09820084 chr6:18387507 RNF144B 0.52 6.89 0.36 2.89e-11 Thyroid stimulating hormone; CRC cis rs7680126 0.596 rs17418533 chr4:10316941 T/C cg11266682 chr4:10021025 SLC2A9 -0.44 -6.63 -0.34 1.35e-10 Urate levels in lean individuals;Urate levels in overweight individuals;Urate levels in obese individuals; CRC cis rs6951245 0.935 rs118132455 chr7:1068232 C/A cg21664854 chr7:1097933 C7orf50;GPR146 0.79 8.92 0.44 3.39e-17 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs7617773 0.817 rs35456569 chr3:48250899 T/A cg11946769 chr3:48343235 NME6 0.72 9.67 0.47 1.22e-19 Coronary artery disease; CRC cis rs2982552 1.000 rs2982551 chr6:152061210 G/T cg22157087 chr6:152012887 ESR1 0.45 7.12 0.37 6.91e-12 Bone properties (heel); CRC cis rs10751667 0.666 rs7394427 chr11:970405 G/A ch.11.42038R chr11:967971 AP2A2 0.58 9.98 0.48 1.16e-20 Alzheimer's disease (late onset); CRC cis rs9443645 0.509 rs9352668 chr6:79572678 A/G cg09184832 chr6:79620586 NA -0.35 -5.88 -0.31 9.94e-9 Intelligence (multi-trait analysis); CRC cis rs9534288 0.619 rs9526143 chr13:46675991 C/T cg15192986 chr13:46630673 CPB2 -0.62 -8.36 -0.42 1.85e-15 Blood protein levels; CRC cis rs782590 0.902 rs782602 chr2:55849309 A/G cg18811423 chr2:55921094 PNPT1 0.78 14.04 0.61 2.14e-35 Metabolic syndrome; CRC cis rs11958404 0.932 rs112683473 chr5:157437819 T/C cg05962755 chr5:157440814 NA 0.95 12.34 0.56 5.17e-29 IgG glycosylation; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg08792129 chr6:99962992 USP45 0.44 6.08 0.32 3.4e-9 Anxiety disorder; CRC cis rs736408 0.608 rs6445534 chr3:52743384 G/A cg08222913 chr3:52553049 STAB1 -0.32 -5.98 -0.31 5.87e-9 Bipolar disorder; CRC trans rs6601450 0.540 rs7824225 chr8:10273246 C/G cg06636001 chr8:8085503 FLJ10661 -0.45 -6.55 -0.34 2.22e-10 Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC trans rs11654801 0.646 rs35597750 chr17:20851636 G/T cg23759823 chr7:139672531 TBXAS1 -0.39 -6.3 -0.33 9.45e-10 Mosquito bite size; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg27430682 chr10:65225552 JMJD1C;LOC84989 -0.38 -6.08 -0.32 3.31e-9 Myopia (pathological); CRC cis rs736408 0.812 rs746694 chr3:52826620 C/T cg10802521 chr3:52805072 NEK4 -0.48 -6.84 -0.35 3.84e-11 Bipolar disorder; CRC cis rs6502050 0.769 rs11658272 chr17:80084596 C/T cg19223190 chr17:80058835 NA -0.39 -6.24 -0.33 1.31e-9 Life satisfaction; CRC cis rs7552404 0.924 rs1146588 chr1:76229787 C/G cg22875332 chr1:76189707 ACADM 0.7 10.57 0.5 1.15e-22 Blood metabolite levels;Acylcarnitine levels; CRC cis rs7762018 1.000 rs6942332 chr6:170131934 A/G cg19338460 chr6:170058176 WDR27 -0.67 -7.42 -0.38 9.76e-13 Thiazide-induced adverse metabolic effects in hypertensive patients; CRC cis rs10504229 0.728 rs17804365 chr8:58151537 C/A cg05313129 chr8:58192883 C8orf71 -0.47 -6.18 -0.32 1.94e-9 Developmental language disorder (linguistic errors); CRC cis rs3820928 0.692 rs17416354 chr2:227770844 A/G cg11843606 chr2:227700838 RHBDD1 -0.48 -7.72 -0.39 1.38e-13 Pulmonary function; CRC cis rs9388451 0.531 rs9375414 chr6:126154475 G/A cg05901451 chr6:126070800 HEY2 -0.4 -5.84 -0.31 1.26e-8 Brugada syndrome; CRC cis rs10256972 0.732 rs1574108 chr7:1105805 T/C cg23978390 chr7:1156363 C7orf50 0.42 5.64 0.3 3.6e-8 Longevity;Endometriosis; CRC cis rs6964587 0.626 rs6951795 chr7:91543764 T/C cg17063962 chr7:91808500 NA -0.59 -9.31 -0.46 1.84e-18 Breast cancer; CRC trans rs1499614 0.901 rs2178742 chr7:66197799 G/A cg10756647 chr7:56101905 PSPH 0.75 7.76 0.39 1.06e-13 Gout; CRC cis rs35146811 0.695 rs858509 chr7:99821470 A/G cg13334819 chr7:99746414 C7orf59 0.59 7.53 0.38 4.99e-13 Coronary artery disease; CRC cis rs10540 1.000 rs116876680 chr11:517473 G/T cg03576123 chr11:487126 PTDSS2 -1.04 -10.77 -0.51 2.3e-23 Body mass index; CRC cis rs7726839 0.540 rs55929359 chr5:595956 C/G cg16447950 chr5:562315 NA -0.73 -9.67 -0.47 1.24e-19 Obesity-related traits; CRC cis rs4665809 0.531 rs10199898 chr2:26445485 T/G cg08067268 chr2:26466485 HADHB;HADHA -0.65 -8.34 -0.42 2e-15 Gut microbiome composition (summer); CRC cis rs3106136 0.609 rs4693000 chr4:95107657 T/C cg11021082 chr4:95130006 SMARCAD1 -0.44 -6.26 -0.33 1.22e-9 Capecitabine sensitivity; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg11008510 chr2:60782852 NA 0.45 6.71 0.35 8.69e-11 Intelligence (multi-trait analysis); CRC trans rs1997103 0.911 rs17777 chr7:55380765 T/C cg20935933 chr6:143382018 AIG1 0.51 6.6 0.34 1.66e-10 QRS interval (sulfonylurea treatment interaction); CRC cis rs73200209 0.912 rs11067904 chr12:116529835 C/G cg01776926 chr12:116560359 MED13L 0.47 5.97 0.31 6.23e-9 Total body bone mineral density; CRC cis rs7666738 0.570 rs1869351 chr4:99077286 T/C cg05340658 chr4:99064831 C4orf37 0.49 7.16 0.37 5.35e-12 Colonoscopy-negative controls vs population controls; CRC cis rs514406 0.683 rs10157120 chr1:53210888 A/G cg24675658 chr1:53192096 ZYG11B -0.65 -10.04 -0.48 7.05e-21 Monocyte count; CRC trans rs1005277 0.505 rs7069702 chr10:38247359 G/T cg23533926 chr12:111358616 MYL2 0.45 6.65 0.34 1.19e-10 Extrinsic epigenetic age acceleration; CRC cis rs3820068 0.581 rs16851851 chr1:15929628 C/G cg13390004 chr1:15929781 NA 0.51 7.2 0.37 4.22e-12 Systolic blood pressure; CRC cis rs77956314 0.515 rs10850741 chr12:117432004 A/G cg25972092 chr12:117363249 FBXW8 0.5 5.92 0.31 8.02e-9 Subcortical brain region volumes;Hippocampal volume; CRC cis rs6120849 0.754 rs6087667 chr20:33651887 A/G cg08999081 chr20:33150536 PIGU 0.44 5.71 0.3 2.58e-8 Protein C levels; CRC cis rs1008375 0.868 rs6816286 chr4:17698088 A/G cg16339924 chr4:17578868 LAP3 0.49 6.64 0.34 1.33e-10 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs9372498 0.536 rs724868 chr6:118795152 C/T cg01339444 chr6:118972232 C6orf204 0.55 6.01 0.31 4.93e-9 Diastolic blood pressure; CRC cis rs9309711 0.666 rs6767 chr2:3483205 C/T cg10845886 chr2:3471009 TTC15 -0.4 -6.29 -0.33 9.97e-10 Neurofibrillary tangles; CRC cis rs1555322 0.530 rs2425043 chr20:33868702 T/C cg08210727 chr20:33865349 NA 0.43 5.93 0.31 7.84e-9 Attention deficit hyperactivity disorder; CRC trans rs2303319 0.504 rs1567420 chr2:162475601 C/T cg03774468 chr3:140950104 ACPL2 0.66 6.01 0.31 5.04e-9 Cognitive function; CRC cis rs1451375 0.617 rs880029 chr7:50569927 G/C cg14593290 chr7:50529359 DDC -0.63 -8.34 -0.42 2.06e-15 Malaria; CRC cis rs9649213 0.537 rs6465663 chr7:97918883 C/G cg24562669 chr7:97807699 LMTK2 0.46 7.82 0.4 7.01e-14 Prostate cancer (SNP x SNP interaction); CRC cis rs1707322 0.721 rs6699418 chr1:46100181 G/A cg03146154 chr1:46216737 IPP 0.66 9.69 0.47 1.07e-19 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC trans rs9291683 0.595 rs11731110 chr4:10037346 T/C cg26043149 chr18:55253948 FECH 0.53 8.16 0.41 7.05e-15 Bone mineral density; CRC cis rs6558530 0.965 rs6558529 chr8:1706206 C/T cg19131313 chr8:1704013 NA -0.44 -6.1 -0.32 2.96e-9 Systolic blood pressure; CRC cis rs910316 1.000 rs175449 chr14:75590846 A/T cg08847533 chr14:75593920 NEK9 -0.89 -16.42 -0.67 1.1e-44 Height; CRC cis rs2228479 0.850 rs62052212 chr16:89981960 G/A cg19635926 chr16:89946313 TCF25 0.6 5.96 0.31 6.53e-9 Skin colour saturation; CRC cis rs8077889 0.956 rs116979403 chr17:41849105 G/A cg26893861 chr17:41843967 DUSP3 0.98 12.85 0.58 6.38e-31 Triglycerides; CRC cis rs7659604 1.000 rs6823488 chr4:122664819 A/G cg19748678 chr4:122722346 EXOSC9 0.49 7.47 0.38 7.45e-13 Type 2 diabetes; CRC cis rs10504229 0.679 rs111843870 chr8:58126798 A/G cg05313129 chr8:58192883 C8orf71 -0.43 -6.11 -0.32 2.74e-9 Developmental language disorder (linguistic errors); CRC cis rs4908768 0.501 rs7551849 chr1:8539463 A/G cg20416874 chr1:8611966 RERE -0.45 -6.42 -0.33 4.68e-10 Neuroticism (multi-trait analysis);Subjective well-being (multi-trait analysis); CRC trans rs9650657 0.644 rs10091386 chr8:10696620 A/C cg06636001 chr8:8085503 FLJ10661 -0.41 -6.17 -0.32 2.01e-9 Neuroticism; CRC cis rs17767392 0.560 rs1008517 chr14:72041434 A/G cg13720639 chr14:72061746 SIPA1L1 0.56 6.97 0.36 1.77e-11 Mitral valve prolapse; CRC cis rs9303401 0.659 rs35564417 chr17:56718286 G/T cg10487724 chr17:56770010 TEX14;RAD51C 0.78 9.69 0.47 1.07e-19 Cognitive test performance; CRC cis rs6831352 0.918 rs2851248 chr4:100045974 A/G cg13256891 chr4:100009986 ADH5 0.65 8.72 0.43 1.43e-16 Alcohol dependence; CRC trans rs1814175 0.586 rs10769603 chr11:49688837 T/C cg15704280 chr7:45808275 SEPT13 -0.88 -14.61 -0.63 1.28e-37 Height; CRC cis rs898097 1.000 rs898098 chr17:80904564 G/A cg15369054 chr17:80825471 TBCD -0.43 -7.06 -0.36 1e-11 Breast cancer; CRC cis rs8060686 0.641 rs113704872 chr16:68032598 G/A cg07125278 chr16:67683757 RLTPR -0.57 -5.83 -0.31 1.29e-8 HDL cholesterol;Metabolic syndrome; CRC cis rs9409565 0.516 rs114766729 chr9:97069901 C/T cg04523069 chr9:97136363 HIATL1 -0.39 -6.09 -0.32 3.19e-9 Colorectal cancer (alcohol consumption interaction); CRC cis rs7666738 0.830 rs13102369 chr4:99045912 A/G cg05340658 chr4:99064831 C4orf37 0.6 9.35 0.46 1.4e-18 Colonoscopy-negative controls vs population controls; CRC cis rs938554 0.876 rs7670751 chr4:9938773 A/C cg00071950 chr4:10020882 SLC2A9 -0.41 -5.82 -0.31 1.43e-8 Blood metabolite levels; CRC trans rs7671189 0.502 rs1114553 chr4:11739401 G/A cg18054620 chr5:111191530 C5orf13 -0.3 -6.03 -0.32 4.39e-9 Obesity-related traits; CRC cis rs4969178 0.965 rs11077362 chr17:76397219 A/T cg20026190 chr17:76395443 PGS1 0.4 6.2 0.32 1.73e-9 HDL cholesterol levels; CRC cis rs11155671 0.530 rs9383912 chr6:150206615 T/C cg13206674 chr6:150067644 NUP43 0.48 6.89 0.36 2.79e-11 Testicular germ cell tumor; CRC cis rs4862750 0.872 rs4862747 chr4:187877236 A/T cg10295955 chr4:187884368 NA 1.02 25.75 0.82 7.68e-81 Lobe attachment (rater-scored or self-reported); CRC cis rs904251 0.523 rs2776870 chr6:37481364 C/A cg01843034 chr6:37503916 NA -0.44 -8.26 -0.41 3.64e-15 Cognitive performance; CRC cis rs832540 0.864 rs832576 chr5:56163255 C/A cg24531977 chr5:56204891 C5orf35 -0.44 -6.71 -0.35 8.63e-11 Coronary artery disease; CRC trans rs2243480 1.000 rs1404147 chr7:65264524 C/T cg10756647 chr7:56101905 PSPH 0.66 7.81 0.4 7.97e-14 Diabetic kidney disease; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg11437374 chr5:169010780 CCDC99 0.41 6.57 0.34 2.02e-10 Liver disease severity in Alagille syndrome; CRC cis rs2625529 0.730 rs12912771 chr15:72162928 A/T cg16672083 chr15:72433130 SENP8 -0.45 -6.79 -0.35 5.13e-11 Red blood cell count; CRC cis rs7618915 0.508 rs13065851 chr3:52644836 T/A cg18099408 chr3:52552593 STAB1 -0.44 -7.28 -0.37 2.4e-12 Bipolar disorder; CRC cis rs6684514 1.000 rs12117951 chr1:156305286 G/A cg16558208 chr1:156270281 VHLL 0.56 8.78 0.44 9.36e-17 Mean corpuscular hemoglobin concentration;Glycated hemoglobin levels; CRC cis rs1401999 1.000 rs2313217 chr3:183635997 A/G cg05044414 chr3:183734942 ABCC5 0.47 8.08 0.41 1.21e-14 Anterior chamber depth; CRC cis rs4654899 0.931 rs10799669 chr1:21172501 T/C cg02927042 chr1:21476669 EIF4G3 0.4 6.23 0.32 1.41e-9 Superior frontal gyrus grey matter volume; CRC cis rs6988636 1.000 rs13261100 chr8:124190312 G/A cg27053337 chr8:124217698 FAM83A 0.43 6.59 0.34 1.74e-10 Urinary uromodulin levels; CRC cis rs933688 0.759 rs1423593 chr5:90752351 T/G cg02339078 chr5:90679543 LOC100129716;ARRDC3 0.84 13.01 0.58 1.74e-31 Smoking behavior; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg25820971 chr14:21852127 SUPT16H 0.41 6.25 0.33 1.25e-9 Liver disease severity in Alagille syndrome; CRC cis rs2996428 0.667 rs61768933 chr1:3766587 G/A cg13057898 chr1:3703894 LRRC47 0.52 6.94 0.36 2.04e-11 Red cell distribution width; CRC trans rs7618501 1.000 rs695238 chr3:49869158 A/C cg21665057 chr3:196295764 WDR53;FBXO45 0.86 15.99 0.66 5.77e-43 Intelligence (multi-trait analysis); CRC cis rs9311474 0.597 rs6778735 chr3:52565100 T/C cg11645453 chr3:52864694 ITIH4 0.31 5.69 0.3 2.89e-8 Electroencephalogram traits; CRC cis rs6879260 1.000 rs6879260 chr5:179731014 A/G cg26918954 chr5:179728553 GFPT2 -0.42 -7.13 -0.37 6.47e-12 Height; CRC cis rs7512552 0.839 rs698919 chr1:150387000 A/G cg15654264 chr1:150340011 RPRD2 0.59 8.52 0.43 5.96e-16 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); CRC cis rs11098499 0.954 rs67265404 chr4:120359270 C/T cg09307838 chr4:120376055 NA 0.71 10.86 0.51 1.13e-23 Corneal astigmatism; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg04445988 chr6:75994563 TMEM30A -0.45 -6.31 -0.33 9.01e-10 Myopia (pathological); CRC cis rs28735056 0.967 rs11662248 chr18:77619009 C/T cg20368463 chr18:77673604 PQLC1 -0.52 -7.78 -0.39 9.75e-14 Schizophrenia; CRC cis rs17270561 0.636 rs12194699 chr6:25729229 G/C cg17691542 chr6:26056736 HIST1H1C 0.73 9.31 0.46 1.82e-18 Iron status biomarkers; CRC cis rs9325144 0.647 rs12231313 chr12:39101929 C/T cg26384229 chr12:38710491 ALG10B -0.52 -7.34 -0.37 1.74e-12 Morning vs. evening chronotype; CRC cis rs898097 0.783 rs11650335 chr17:80835111 A/G cg03160526 chr17:80928410 B3GNTL1 -0.41 -5.84 -0.31 1.24e-8 Breast cancer; CRC trans rs1642645 0.831 rs6689536 chr1:42487523 T/C cg16926213 chr1:1841314 NA -0.42 -6.07 -0.32 3.57e-9 Left ventricular obstructive tract defect (maternal effect); CRC cis rs6121246 0.567 rs6060261 chr20:30192948 C/G cg18721089 chr20:30220636 NA -0.52 -7.93 -0.4 3.54e-14 Mean corpuscular hemoglobin; CRC cis rs7412746 0.621 rs72704656 chr1:150828307 A/G cg10589385 chr1:150898437 SETDB1 0.3 6.1 0.32 3e-9 Melanoma; CRC cis rs3750965 0.959 rs4930265 chr11:68855954 A/G cg06818126 chr11:68850279 TPCN2 -0.43 -6.0 -0.31 5.08e-9 Hair color; CRC cis rs28386778 0.897 rs7212196 chr17:61834981 T/C cg23090583 chr17:61904693 PSMC5;FTSJ3 1.05 20.01 0.74 7.51e-59 Prudent dietary pattern; CRC cis rs10503871 0.690 rs7812836 chr8:30352258 A/G cg26383811 chr8:30366931 RBPMS -0.47 -7.37 -0.38 1.35e-12 Metabolite levels (X-11787); CRC cis rs7726839 0.574 rs72707007 chr5:661856 T/C cg14541582 chr5:601475 NA -0.33 -6.48 -0.34 3.34e-10 Obesity-related traits; CRC trans rs208520 0.779 rs208451 chr6:66906155 G/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.9 -11.28 -0.53 3.66e-25 Exhaled nitric oxide output; CRC cis rs2239547 0.657 rs4687672 chr3:52880543 G/A cg11645453 chr3:52864694 ITIH4 0.59 10.55 0.5 1.36e-22 Schizophrenia; CRC cis rs11690935 0.959 rs67204065 chr2:172672624 G/A cg13550731 chr2:172543902 DYNC1I2 -1.07 -17.44 -0.69 1.11e-48 Schizophrenia; CRC cis rs16867335 1.000 rs35579320 chr2:181463612 T/C cg23363182 chr2:181467187 NA -0.49 -6.62 -0.34 1.45e-10 Survival in rectal cancer; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg12198157 chr3:134204547 CEP63;ANAPC13 0.42 6.14 0.32 2.34e-9 Intelligence (multi-trait analysis); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg19109955 chr19:39138207 ACTN4 0.37 5.98 0.31 5.68e-9 Liver disease severity in Alagille syndrome; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg05893365 chr16:67260970 LRRC29;TMEM208 0.42 6.11 0.32 2.89e-9 Intelligence (multi-trait analysis); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg02952494 chr16:1818699 MAPK8IP3 -0.42 -6.95 -0.36 1.91e-11 Liver disease severity in Alagille syndrome; CRC cis rs972578 1.000 rs1546860 chr22:43400329 T/C cg01576275 chr22:43409880 NA -0.49 -8.0 -0.4 2.13e-14 Mean platelet volume; CRC cis rs13256369 0.951 rs13270852 chr8:8566853 A/G cg18904891 chr8:8559673 CLDN23 0.54 7.2 0.37 4.23e-12 Obesity-related traits; CRC cis rs2180341 0.960 rs9398842 chr6:127674662 T/C cg24812749 chr6:127587940 RNF146 0.91 13.0 0.58 1.85e-31 Breast cancer; CRC cis rs8180040 0.966 rs11716763 chr3:47518266 C/T cg27129171 chr3:47204927 SETD2 -0.6 -9.27 -0.45 2.59e-18 Colorectal cancer; CRC cis rs7208859 0.623 rs216446 chr17:28933718 T/G cg13385521 chr17:29058706 SUZ12P 0.58 6.35 0.33 7.04e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs1862618 0.641 rs170733 chr5:56249251 A/G cg12311346 chr5:56204834 C5orf35 0.65 9.93 0.48 1.69e-20 Initial pursuit acceleration; CRC cis rs7914558 1.000 rs4917380 chr10:104775335 C/G cg15744005 chr10:104629667 AS3MT -0.32 -6.87 -0.35 3.16e-11 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs9534288 0.730 rs7985754 chr13:46581287 G/A cg15192986 chr13:46630673 CPB2 -0.67 -9.85 -0.48 3.16e-20 Blood protein levels; CRC cis rs9640161 0.750 rs3735167 chr7:150039555 C/T cg12556325 chr7:150026731 C7orf29;LRRC61 -0.5 -7.21 -0.37 3.97e-12 Blood protein levels;Circulating chemerin levels; CRC cis rs16867321 0.951 rs9989767 chr2:181429886 C/T cg23363182 chr2:181467187 NA -0.53 -6.74 -0.35 6.97e-11 Obesity; CRC cis rs3096299 0.658 rs3934737 chr16:89560209 G/A cg08392591 chr16:89556376 ANKRD11 0.42 5.73 0.3 2.31e-8 Multiple myeloma (IgH translocation); CRC cis rs523522 0.962 rs4767903 chr12:120930046 G/A cg12219531 chr12:120966889 COQ5 0.61 8.42 0.42 1.16e-15 High light scatter reticulocyte count; CRC cis rs11155671 0.530 rs9383912 chr6:150206615 T/C cg07701084 chr6:150067640 NUP43 0.49 7.22 0.37 3.74e-12 Testicular germ cell tumor; CRC cis rs6684514 1.000 rs12132919 chr1:156318141 C/A cg16558208 chr1:156270281 VHLL 0.56 8.42 0.42 1.17e-15 Mean corpuscular hemoglobin concentration;Glycated hemoglobin levels; CRC cis rs4237845 0.591 rs10747788 chr12:58315338 C/T cg02175503 chr12:58329896 NA 0.71 9.77 0.47 5.89e-20 Intelligence (multi-trait analysis); CRC cis rs11148252 0.538 rs3368 chr13:52707240 C/G cg00495681 chr13:53174319 NA 0.62 9.28 0.46 2.27e-18 Lewy body disease; CRC cis rs1797081 0.967 rs780633 chr10:16863161 C/T cg23933602 chr10:16859644 RSU1 1.09 24.24 0.8 3.53e-75 Platelet distribution width; CRC cis rs3858526 0.959 rs1840179 chr11:5949148 A/G cg05234568 chr11:5960015 NA -0.59 -8.1 -0.41 1.07e-14 DNA methylation (variation); CRC cis rs514406 0.929 rs483073 chr1:53314084 T/C cg27535305 chr1:53392650 SCP2 -0.38 -7.05 -0.36 1.03e-11 Monocyte count; CRC cis rs853679 0.517 rs9380061 chr6:28132803 T/C cg03623178 chr6:28175578 NA 0.98 12.66 0.57 3.31e-30 Depression; CRC cis rs17253792 0.822 rs17683656 chr14:56053361 C/T cg24579896 chr14:56047964 C14orf33;KTN1 -0.71 -5.81 -0.31 1.48e-8 Putamen volume; CRC cis rs9858542 0.953 rs11713474 chr3:49611457 A/G cg03060546 chr3:49711283 APEH -0.47 -6.43 -0.33 4.44e-10 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs9372498 0.505 rs9320655 chr6:118830981 T/C cg18833306 chr6:118973337 C6orf204 0.45 5.95 0.31 6.94e-9 Diastolic blood pressure; CRC cis rs9611565 0.879 rs5758311 chr22:41759375 G/T cg06634786 chr22:41940651 POLR3H -0.47 -6.27 -0.33 1.13e-9 Vitiligo; CRC cis rs6952808 0.531 rs73039217 chr7:2178731 G/A cg02951883 chr7:2050386 MAD1L1 -0.59 -8.74 -0.43 1.22e-16 Bipolar disorder and schizophrenia; CRC cis rs10128264 0.902 rs2802360 chr10:80971196 C/T cg18737081 chr10:80999807 ZMIZ1 -0.38 -6.65 -0.34 1.23e-10 Response to methotrexate in juvenile idiopathic arthritis; CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg05622441 chr16:69419962 TERF2 0.4 6.47 0.34 3.6e-10 Obesity-related traits; CRC cis rs4665809 1.000 rs6704930 chr2:26325705 G/A cg04944784 chr2:26401820 FAM59B -0.6 -7.67 -0.39 1.98e-13 Gut microbiome composition (summer); CRC cis rs79387448 0.655 rs3771167 chr2:102986188 A/G cg09003973 chr2:102972529 NA 0.98 10.96 0.52 4.8e-24 Gut microbiota (bacterial taxa); CRC cis rs920590 0.758 rs1817836 chr8:19664852 T/C cg03894339 chr8:19674705 INTS10 0.42 5.84 0.31 1.28e-8 Acute lymphoblastic leukemia (childhood); CRC trans rs8002861 0.664 rs1466005 chr13:44424210 T/C cg12856521 chr11:46389249 DGKZ 0.44 7.18 0.37 4.65e-12 Leprosy; CRC cis rs7552404 0.920 rs1612097 chr1:76218875 C/T cg22875332 chr1:76189707 ACADM 0.69 10.56 0.5 1.2e-22 Blood metabolite levels;Acylcarnitine levels; CRC cis rs3820068 0.603 rs3766163 chr1:15986547 T/C cg13390004 chr1:15929781 NA 0.53 7.27 0.37 2.66e-12 Systolic blood pressure; CRC cis rs6674970 0.518 rs15740 chr1:151040435 G/A cg03258749 chr1:151040405 MLLT11 -0.59 -8.96 -0.44 2.51e-17 Childhood ear infection; CRC cis rs2569991 0.588 rs2596909 chr3:12928672 G/C cg22481960 chr3:13008800 IQSEC1 -0.47 -6.11 -0.32 2.86e-9 Periodontitis (DPAL); CRC cis rs6502050 0.635 rs9889327 chr17:80087839 G/A cg19223190 chr17:80058835 NA 0.39 6.16 0.32 2.12e-9 Life satisfaction; CRC cis rs6701037 0.566 rs729675 chr1:175136946 T/C cg00321850 chr1:175162397 KIAA0040 0.45 7.58 0.39 3.65e-13 Alcohol dependence; CRC cis rs3106136 0.967 rs12499309 chr4:95171284 G/A cg11021082 chr4:95130006 SMARCAD1 -0.47 -7.39 -0.38 1.22e-12 Capecitabine sensitivity; CRC cis rs10504229 0.683 rs2318143 chr8:58114660 C/T cg05313129 chr8:58192883 C8orf71 -0.43 -6.0 -0.31 5.07e-9 Developmental language disorder (linguistic errors); CRC cis rs34172651 0.517 rs2303084 chr16:24834581 G/C cg02428538 chr16:24856791 SLC5A11 -0.6 -6.81 -0.35 4.66e-11 Intelligence (multi-trait analysis); CRC trans rs17685 0.712 rs59659102 chr7:75710114 G/A cg19862616 chr7:65841803 NCRNA00174 0.98 18.26 0.71 6.01e-52 Coffee consumption;Coffee consumption (cups per day); CRC cis rs751728 0.931 rs2296746 chr6:33744711 C/T cg25922239 chr6:33757077 LEMD2 0.62 9.74 0.47 7.16e-20 Crohn's disease; CRC cis rs4268898 0.722 rs6723257 chr2:24391129 A/G cg06627628 chr2:24431161 ITSN2 0.45 6.57 0.34 1.93e-10 Asthma; CRC cis rs713587 0.713 rs4665276 chr2:25213333 C/T cg04586622 chr2:25135609 ADCY3 0.36 6.1 0.32 3e-9 Body mass index in non-asthmatics; CRC cis rs875971 0.545 rs35459055 chr7:65944386 G/A cg05627663 chr7:65219948 SNORA22;CCT6P1 0.54 6.95 0.36 1.91e-11 Aortic root size; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg16978263 chr3:160118452 SMC4;IFT80 0.52 6.68 0.35 1.03e-10 Thyroid stimulating hormone; CRC cis rs6840360 0.615 rs4696094 chr4:152465501 C/T cg09659197 chr4:152720779 NA 0.31 5.66 0.3 3.23e-8 Intelligence (multi-trait analysis); CRC trans rs2727020 0.553 rs3907576 chr11:49536639 A/C cg11707556 chr5:10655725 ANKRD33B -0.4 -7.43 -0.38 9.53e-13 Coronary artery disease; CRC cis rs61160187 0.522 rs2045356 chr5:59947354 C/T cg02684056 chr5:59996105 DEPDC1B 0.41 5.94 0.31 7.14e-9 Educational attainment (years of education);Educational attainment (college completion); CRC cis rs5769707 0.935 rs1109320 chr22:49989106 G/A cg05373962 chr22:49881684 NA -0.34 -6.62 -0.34 1.42e-10 Monocyte count;Monocyte percentage of white cells; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg07481335 chr14:65879396 FUT8;LOC645431 0.44 6.31 0.33 8.88e-10 Anxiety disorder; CRC cis rs651907 0.535 rs2290859 chr3:101525625 C/T cg12386194 chr3:101231763 SENP7 0.51 7.51 0.38 5.65e-13 Colorectal cancer; CRC cis rs870825 0.616 rs79884757 chr4:185621454 A/G cg04058563 chr4:185651563 MLF1IP 0.72 9.38 0.46 1.12e-18 Blood protein levels; CRC cis rs7122539 0.734 rs4930391 chr11:66645254 A/G cg24851651 chr11:66362959 CCS -0.49 -8.85 -0.44 5.6e-17 HIV-1 susceptibility; CRC cis rs6912958 0.781 rs2268993 chr6:88184111 G/A cg08069147 chr6:88032118 GJB7;C6orf162 -0.55 -8.23 -0.41 4.5e-15 Monocyte percentage of white cells; CRC cis rs12971120 0.947 rs3764509 chr18:72167124 C/G cg26446133 chr18:72167187 CNDP2 -0.77 -15.35 -0.65 1.83e-40 Refractive error; CRC cis rs853679 0.517 rs9357061 chr6:28051772 A/G cg02683197 chr6:28174875 NA 0.81 9.98 0.48 1.15e-20 Depression; CRC cis rs7725052 0.609 rs12153402 chr5:40463412 G/A cg09067459 chr5:40385259 NA 0.4 6.68 0.35 9.91e-11 Pediatric autoimmune diseases; CRC cis rs4957048 0.891 rs11960196 chr5:568857 C/A cg14541582 chr5:601475 NA -0.28 -5.87 -0.31 1.08e-8 Ulcerative colitis; CRC cis rs2758596 0.850 rs2842879 chr1:156163695 G/T cg25208724 chr1:156163844 SLC25A44 0.73 7.19 0.37 4.5e-12 Paclitaxel disposition in epithelial ovarian cancer; CRC cis rs7208859 0.623 rs28556733 chr17:29083945 T/G cg13385521 chr17:29058706 SUZ12P 0.73 8.33 0.42 2.14e-15 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs17711722 0.565 rs73372653 chr7:65442795 A/T cg18876405 chr7:65276391 NA 0.51 8.36 0.42 1.82e-15 Calcium levels; CRC cis rs344364 0.511 rs2917515 chr16:1945271 G/C cg00046913 chr16:1877150 HAGH;FAHD1 -0.62 -6.15 -0.32 2.19e-9 Glomerular filtration rate in chronic kidney disease; CRC cis rs9911578 1.000 rs1472288 chr17:56910720 G/A cg12560992 chr17:57184187 TRIM37 0.92 16.91 0.68 1.29e-46 Intelligence (multi-trait analysis); CRC cis rs55675132 0.510 rs12130524 chr1:115287833 T/C cg12756093 chr1:115239321 AMPD1 0.52 6.24 0.33 1.34e-9 Schizophrenia; CRC cis rs6570726 0.791 rs383841 chr6:145888329 G/T cg05347473 chr6:146136440 FBXO30 -0.39 -6.01 -0.31 4.97e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs9916302 0.653 rs11657058 chr17:37699378 T/G cg15445000 chr17:37608096 MED1 0.35 6.24 0.33 1.34e-9 Glomerular filtration rate (creatinine); CRC trans rs2303319 0.504 rs62189005 chr2:162562386 T/C cg12500891 chr11:57225987 NA -0.67 -6.03 -0.32 4.51e-9 Cognitive function; CRC cis rs780096 0.565 rs11681351 chr2:27743423 G/A cg12000995 chr2:27665139 KRTCAP3 -0.3 -6.04 -0.32 4.09e-9 Total body bone mineral density; CRC cis rs4713118 0.955 rs9393847 chr6:27687973 G/A cg26587870 chr6:27730563 NA -0.43 -6.37 -0.33 6.38e-10 Parkinson's disease; CRC cis rs2718058 0.639 rs2597270 chr7:37762014 A/G cg24998770 chr7:37888106 TXNDC3 -0.36 -5.9 -0.31 8.94e-9 Alzheimer's disease (late onset); CRC cis rs10493773 0.775 rs11161662 chr1:86185040 A/G cg17807903 chr1:86174739 ZNHIT6 -0.54 -12.05 -0.55 5.98e-28 Urate levels in overweight individuals; CRC trans rs7395662 0.591 rs4882233 chr11:48739653 A/G cg15704280 chr7:45808275 SEPT13 -0.52 -7.62 -0.39 2.7e-13 HDL cholesterol; CRC cis rs7208859 0.673 rs2269916 chr17:29233763 A/G cg01831904 chr17:28903510 LRRC37B2 -0.56 -5.83 -0.31 1.35e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs870825 0.616 rs7682505 chr4:185640648 C/T cg04058563 chr4:185651563 MLF1IP 0.73 9.54 0.47 3.32e-19 Blood protein levels; CRC cis rs1799949 1.000 rs12936831 chr17:41331816 C/T cg01879757 chr17:41196368 BRCA1 -0.44 -6.69 -0.35 9.45e-11 Menopause (age at onset); CRC cis rs1153858 1.000 rs10444821 chr15:45647236 C/T cg21132104 chr15:45694354 SPATA5L1 0.59 8.71 0.43 1.49e-16 Homoarginine levels; CRC cis rs270601 0.710 rs4705852 chr5:131602807 A/G cg27615366 chr5:131592974 PDLIM4 0.34 6.46 0.34 3.73e-10 Acylcarnitine levels; CRC cis rs763014 0.966 rs4247097 chr16:654224 G/A cg04497992 chr16:616212 NHLRC4 0.45 7.25 0.37 3.06e-12 Height; CRC cis rs362272 0.524 rs10937924 chr4:3374898 T/C cg11522145 chr4:3412961 RGS12 -0.37 -5.8 -0.3 1.55e-8 Serum sulfate level; CRC trans rs7395662 0.591 rs4882233 chr11:48739653 A/G cg21153622 chr11:89784906 NA -0.52 -8.77 -0.44 9.87e-17 HDL cholesterol; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg09188840 chr17:4699533 PSMB6 0.38 6.14 0.32 2.43e-9 Liver disease severity in Alagille syndrome; CRC cis rs1862618 0.671 rs72644088 chr5:56241019 G/A cg24531977 chr5:56204891 C5orf35 0.66 10.09 0.49 5.09e-21 Initial pursuit acceleration; CRC cis rs6582630 0.537 rs12823925 chr12:38409323 C/T cg26384229 chr12:38710491 ALG10B 0.69 9.77 0.47 5.95e-20 Drug-induced liver injury (flucloxacillin); CRC cis rs116095464 0.558 rs10077076 chr5:231940 C/T cg22857025 chr5:266934 NA -1.22 -16.68 -0.68 1.07e-45 Breast cancer; CRC cis rs9747201 1.000 rs58472289 chr17:80111895 G/T cg09264619 chr17:80180166 NA 0.51 7.31 0.37 1.99e-12 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs4148883 0.504 rs4585310 chr4:100120233 T/C cg12011299 chr4:100065546 ADH4 -0.38 -8.52 -0.43 5.62e-16 Alcohol dependence; CRC cis rs1005277 0.579 rs2472175 chr10:38382901 T/G cg25517755 chr10:38738941 LOC399744 -0.44 -6.42 -0.33 4.85e-10 Extrinsic epigenetic age acceleration; CRC trans rs1455244 0.700 rs7229302 chr18:11508904 G/T cg16214573 chr11:120081755 OAF 0.37 5.99 0.31 5.54e-9 Schizophrenia; CRC cis rs727505 0.821 rs67167896 chr7:124614127 T/C cg23710748 chr7:124431027 NA -0.81 -14.24 -0.62 3.57e-36 Lewy body disease; CRC cis rs2857891 0.909 rs56261447 chr11:6939382 A/C cg02416716 chr11:6948024 ZNF215 0.57 5.86 0.31 1.14e-8 Response to cytadine analogues (cytosine arabinoside); CRC cis rs6540559 0.605 rs3753518 chr1:209977964 G/C cg25204440 chr1:209979598 IRF6 0.49 5.8 0.3 1.55e-8 Cleft lip with or without cleft palate; CRC cis rs9611565 0.527 rs73178638 chr22:41942904 T/C cg03806693 chr22:41940476 POLR3H -1.14 -14.78 -0.63 2.96e-38 Vitiligo; CRC cis rs2243480 1.000 rs316304 chr7:65616894 T/C cg25985355 chr7:65971099 NA -0.53 -6.05 -0.32 3.9e-9 Diabetic kidney disease; CRC cis rs6951245 0.935 rs11763765 chr7:1060510 C/T cg03188948 chr7:1209495 NA 0.59 6.13 0.32 2.48e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs9527 0.830 rs10883790 chr10:104640955 A/C cg15744005 chr10:104629667 AS3MT -0.35 -6.5 -0.34 2.89e-10 Arsenic metabolism; CRC cis rs17401966 1.000 rs6700866 chr1:10306038 A/G cg19773385 chr1:10388646 KIF1B -0.54 -7.53 -0.38 4.86e-13 Hepatocellular carcinoma; CRC cis rs1691799 0.867 rs1183274 chr12:66732057 C/G cg16791601 chr12:66731901 HELB -0.67 -11.29 -0.53 3.27e-25 White blood cell count (basophil); CRC cis rs11098499 0.739 rs10031033 chr4:120151452 C/T cg09307838 chr4:120376055 NA 0.52 8.09 0.41 1.13e-14 Corneal astigmatism; CRC cis rs9894429 0.646 rs7220310 chr17:79606056 C/A cg18240062 chr17:79603768 NPLOC4 0.47 7.38 0.38 1.34e-12 Eye color traits; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg17392648 chr5:68788941 OCLN 0.41 6.02 0.31 4.7e-9 Response to antipsychotic treatment; CRC cis rs12024301 0.557 rs12044718 chr1:183616403 T/C cg11505048 chr1:183622726 RGL1;APOBEC4 0.81 7.12 0.37 6.85e-12 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs709400 1.000 rs56660916 chr14:104126137 G/T cg24130564 chr14:104152367 KLC1 -0.44 -6.61 -0.34 1.54e-10 Body mass index; CRC cis rs9359856 0.913 rs9362663 chr6:90307550 A/C cg13799429 chr6:90582589 CASP8AP2 0.43 6.06 0.32 3.63e-9 Bipolar disorder; CRC cis rs1153858 1.000 rs4534782 chr15:45652933 G/A cg10760299 chr15:45669010 GATM 0.52 8.35 0.42 1.91e-15 Homoarginine levels; CRC cis rs6951245 0.938 rs113642700 chr7:1105654 C/T cg22907277 chr7:1156413 C7orf50 0.74 7.88 0.4 4.73e-14 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs6582630 0.537 rs7310749 chr12:38400472 C/T cg13010199 chr12:38710504 ALG10B 0.47 6.32 0.33 8.35e-10 Drug-induced liver injury (flucloxacillin); CRC cis rs752010 0.746 rs10890146 chr1:42089389 G/A cg06885757 chr1:42089581 HIVEP3 0.5 9.0 0.44 1.9e-17 Lupus nephritis in systemic lupus erythematosus; CRC cis rs11148252 0.532 rs9536262 chr13:53303074 A/C cg12458913 chr13:53173898 NA -0.75 -14.16 -0.62 7.14e-36 Lewy body disease; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg15670579 chr15:102264312 TARSL2 -0.43 -6.42 -0.33 4.83e-10 Myopia (pathological); CRC cis rs2050392 0.517 rs687036 chr10:30761249 G/A cg25182066 chr10:30743637 MAP3K8 -0.52 -7.13 -0.37 6.24e-12 Inflammatory bowel disease; CRC cis rs12701220 0.655 rs10215292 chr7:1135263 A/G cg04498913 chr7:1135747 C7orf50 -0.49 -6.02 -0.31 4.68e-9 Bronchopulmonary dysplasia; CRC cis rs933688 1.000 rs60513756 chr5:90727692 A/C cg26981201 chr5:90679533 LOC100129716;ARRDC3 1.01 15.75 0.66 4.96e-42 Smoking behavior; CRC trans rs561341 0.660 rs7406043 chr17:30220152 C/G cg27661571 chr11:113659931 NA -0.64 -7.36 -0.38 1.44e-12 Hip circumference adjusted for BMI; CRC trans rs11098499 0.722 rs17595727 chr4:120262074 C/T cg25214090 chr10:38739885 LOC399744 -0.56 -9.15 -0.45 6.35e-18 Corneal astigmatism; CRC cis rs9287719 0.967 rs11687023 chr2:10741412 G/A cg00105475 chr2:10696890 NA 0.45 7.3 0.37 2.19e-12 Prostate cancer; CRC cis rs10504229 0.593 rs4738567 chr8:57997033 A/C cg21724239 chr8:58056113 NA 0.58 7.84 0.4 6.33e-14 Developmental language disorder (linguistic errors); CRC trans rs2228479 0.850 rs17227064 chr16:89816314 A/G cg24644049 chr4:85504048 CDS1 0.9 7.46 0.38 7.69e-13 Skin colour saturation; CRC cis rs9457247 1.000 rs444988 chr6:167389674 A/T cg23791538 chr6:167370224 RNASET2 -0.37 -5.74 -0.3 2.18e-8 Crohn's disease; CRC cis rs1448094 0.511 rs10506918 chr12:86227913 A/G cg02569458 chr12:86230093 RASSF9 -0.42 -7.14 -0.37 6.14e-12 Major depressive disorder; CRC cis rs4964805 0.657 rs1866294 chr12:104186795 A/G cg02344784 chr12:104178138 NT5DC3 0.79 15.03 0.64 3.07e-39 Attention deficit hyperactivity disorder; CRC cis rs7811142 0.830 rs11761426 chr7:99956893 A/T cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.11 15.96 0.66 7.52e-43 Platelet count; CRC cis rs875971 0.651 rs2420596 chr7:65915983 T/C cg18876405 chr7:65276391 NA 0.51 8.36 0.42 1.77e-15 Aortic root size; CRC cis rs853679 0.517 rs9393888 chr6:28059217 G/C cg12273811 chr6:28175739 NA 0.74 9.41 0.46 8.58e-19 Depression; CRC cis rs6951245 1.000 rs78896566 chr7:1080182 C/G cg24642844 chr7:1081250 C7orf50 -0.78 -9.34 -0.46 1.44e-18 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs17345786 0.953 rs78645744 chr3:101327789 T/A cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.56 6.52 0.34 2.61e-10 Colonoscopy-negative controls vs population controls; CRC cis rs769267 0.929 rs2905431 chr19:19482882 G/A cg03709012 chr19:19516395 GATAD2A -0.73 -11.35 -0.53 1.97e-25 Tonsillectomy; CRC cis rs35306767 0.903 rs34270014 chr10:904666 T/C cg26597838 chr10:835615 NA 0.87 10.95 0.52 5.37e-24 Eosinophil percentage of granulocytes; CRC cis rs2882667 0.690 rs288035 chr5:138212417 A/T cg09476006 chr5:138032270 NA 0.54 8.92 0.44 3.21e-17 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs79057730 0.599 rs9458 chr7:825494 A/G cg06242242 chr7:766104 PRKAR1B;HEATR2 -0.62 -6.46 -0.34 3.84e-10 Initial pursuit acceleration; CRC cis rs473651 0.935 rs540636 chr2:239358341 T/C cg08773314 chr2:239334832 ASB1 0.39 8.87 0.44 4.6e-17 Multiple system atrophy; CRC cis rs4654899 0.758 rs35913932 chr1:21423025 G/T cg02927042 chr1:21476669 EIF4G3 -0.41 -6.53 -0.34 2.49e-10 Superior frontal gyrus grey matter volume; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg23355997 chr17:7154831 DULLARD;C17orf81 0.51 8.19 0.41 5.89e-15 Liver disease severity in Alagille syndrome; CRC cis rs6496044 0.634 rs4843066 chr15:86062911 C/T cg17133734 chr15:86042851 AKAP13 0.43 6.86 0.35 3.49e-11 Interstitial lung disease; CRC cis rs6728642 0.908 rs10207116 chr2:98018281 G/A cg26665480 chr2:98280029 ACTR1B -0.51 -5.92 -0.31 8.22e-9 Bipolar disorder lithium response (continuous) or schizophrenia; CRC cis rs17666538 0.535 rs1669658 chr8:607380 A/G cg07685180 chr8:600429 NA 0.7 6.77 0.35 5.78e-11 IgG glycosylation; CRC cis rs6963495 0.818 rs73190187 chr7:105164401 A/T cg13798780 chr7:105162888 PUS7 0.68 8.08 0.41 1.27e-14 Bipolar disorder (body mass index interaction); CRC cis rs9891119 0.550 rs3736162 chr17:40497839 G/C cg06270615 chr17:40516068 STAT3 -0.35 -7.42 -0.38 9.96e-13 Multiple sclerosis;Crohn's disease; CRC cis rs9463078 0.528 rs12214778 chr6:44924412 A/G cg25276700 chr6:44698697 NA 0.24 5.61 0.3 4.41e-8 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; CRC cis rs231513 1.000 rs231513 chr17:41965200 C/G cg26893861 chr17:41843967 DUSP3 -0.71 -6.4 -0.33 5.27e-10 Cognitive function; CRC cis rs932287 0.540 rs4910442 chr11:9044337 T/C cg12365402 chr11:9010492 NRIP3 0.45 7.21 0.37 3.9e-12 Colonoscopy-negative controls vs population controls; CRC cis rs7666738 0.830 rs6819047 chr4:98866902 G/A cg05340658 chr4:99064831 C4orf37 0.56 8.33 0.42 2.21e-15 Colonoscopy-negative controls vs population controls; CRC cis rs9611519 0.780 rs3171692 chr22:41642212 C/T cg06634786 chr22:41940651 POLR3H -0.49 -6.48 -0.34 3.43e-10 Neuroticism; CRC cis rs9469913 0.542 rs75398113 chr6:34728071 G/C cg17674042 chr6:34482479 PACSIN1 -0.89 -7.9 -0.4 4.21e-14 Body mass index (joint analysis main effects and physical activity interaction);Body mass index;Body mass index in physically active individuals; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg12163800 chr17:74475355 RHBDF2 -0.36 -5.98 -0.31 5.9e-9 Liver disease severity in Alagille syndrome; CRC cis rs3849570 0.615 rs6766011 chr3:81986136 G/A cg07356753 chr3:81810745 GBE1 -0.47 -6.34 -0.33 7.79e-10 Waist circumference;Body mass index; CRC cis rs990171 0.955 rs6720564 chr2:103079297 T/C cg03938978 chr2:103052716 IL18RAP 0.46 5.85 0.31 1.17e-8 Lymphocyte counts; CRC cis rs2243480 1.000 rs35542501 chr7:65431215 T/C cg18252515 chr7:66147081 NA -1.06 -12.42 -0.56 2.67e-29 Diabetic kidney disease; CRC cis rs6570726 0.791 rs392612 chr6:145881586 C/G cg13319975 chr6:146136371 FBXO30 0.43 6.19 0.32 1.79e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs12142240 0.698 rs72677599 chr1:46834251 G/A cg00530320 chr1:46809349 NSUN4 0.59 8.11 0.41 1.02e-14 Menopause (age at onset); CRC trans rs1005277 0.563 rs2505215 chr10:38481273 A/G cg17830980 chr10:43048298 ZNF37B -0.6 -9.93 -0.48 1.76e-20 Extrinsic epigenetic age acceleration; CRC cis rs7591163 1.000 rs4973380 chr2:228725402 T/A cg14646075 chr2:228736089 WDR69 -0.44 -5.93 -0.31 7.68e-9 Blood pressure; CRC cis rs1862618 0.756 rs832548 chr5:56183637 G/C cg20203395 chr5:56204925 C5orf35 -0.72 -8.29 -0.42 2.99e-15 Initial pursuit acceleration; CRC cis rs7843479 0.601 rs3824338 chr8:21864540 A/C cg17168535 chr8:21777572 XPO7 0.58 9.83 0.48 3.55e-20 Mean corpuscular volume; CRC cis rs2243480 1.000 rs313803 chr7:65514731 G/A cg12463550 chr7:65579703 CRCP 0.75 6.82 0.35 4.5e-11 Diabetic kidney disease; CRC cis rs883565 0.502 rs4496420 chr3:38942716 A/C cg01426195 chr3:39028469 NA 0.35 5.82 0.31 1.42e-8 Handedness; CRC cis rs8180040 0.705 rs73069104 chr3:47280733 T/C cg27129171 chr3:47204927 SETD2 -0.59 -8.53 -0.43 5.24e-16 Colorectal cancer; CRC cis rs1555322 0.530 rs2297789 chr20:33867248 A/T cg08210727 chr20:33865349 NA 0.45 6.14 0.32 2.33e-9 Attention deficit hyperactivity disorder; CRC cis rs6860806 0.507 rs272883 chr5:131668698 A/G cg18301423 chr5:131593218 PDLIM4 0.37 6.25 0.33 1.27e-9 Breast cancer; CRC cis rs11148252 0.500 rs342768 chr13:53208882 C/T cg00495681 chr13:53174319 NA 0.86 15.72 0.65 6.25e-42 Lewy body disease; CRC cis rs10911232 0.507 rs10911206 chr1:183012423 A/G ch.1.3577855R chr1:183094577 LAMC1 0.83 14.57 0.63 1.8e-37 Hypertriglyceridemia; CRC cis rs11105298 0.891 rs11105314 chr12:89924559 C/T cg00757033 chr12:89920650 WDR51B 0.36 6.03 0.32 4.31e-9 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; CRC cis rs3749237 1.000 rs11717256 chr3:49868520 C/T cg03060546 chr3:49711283 APEH 0.43 6.34 0.33 7.58e-10 Resting heart rate; CRC cis rs2730245 0.959 rs2527201 chr7:158738611 G/T cg24397884 chr7:158709396 WDR60 -0.96 -16.26 -0.67 4.64e-44 Height; CRC cis rs262150 0.644 rs2730228 chr7:158789361 T/C cg10570241 chr7:158785291 NA 0.45 7.69 0.39 1.76e-13 Facial morphology (factor 20); CRC cis rs35306767 0.903 rs7914758 chr10:891702 T/C cg20503657 chr10:835505 NA 1.23 14.72 0.63 4.77e-38 Eosinophil percentage of granulocytes; CRC cis rs11628318 0.853 rs7155171 chr14:103031845 C/T cg23461800 chr14:103021989 NA -0.75 -10.23 -0.49 1.61e-21 Platelet count; CRC cis rs7945705 0.818 rs1988708 chr11:8882893 C/A cg14711859 chr11:8959438 ASCL3 0.45 7.53 0.38 4.86e-13 Hemoglobin concentration; CRC cis rs1862618 0.853 rs1833896 chr5:56097669 C/A cg18230493 chr5:56204884 C5orf35 -0.7 -9.11 -0.45 8.53e-18 Initial pursuit acceleration; CRC cis rs7909074 0.531 rs879344 chr10:45400667 G/C cg04218760 chr10:45406644 TMEM72 -0.31 -7.43 -0.38 9.21e-13 Mean corpuscular volume; CRC trans rs17685 0.672 rs10952841 chr7:75778626 A/C cg19862616 chr7:65841803 NCRNA00174 0.98 18.08 0.71 3.12e-51 Coffee consumption;Coffee consumption (cups per day); CRC cis rs1552244 0.882 rs28366039 chr3:10028988 C/A cg08888203 chr3:10149979 C3orf24 0.57 7.0 0.36 1.41e-11 Alzheimer's disease; CRC cis rs9467711 0.606 rs12174631 chr6:26373150 C/T cg14345882 chr6:26364793 BTN3A2 0.65 5.73 0.3 2.32e-8 Autism spectrum disorder or schizophrenia; CRC cis rs7613875 0.580 rs6808044 chr3:50136165 A/G cg05623727 chr3:50126028 RBM5 -0.63 -10.92 -0.52 6.59e-24 Body mass index; CRC trans rs11650494 0.803 rs117801358 chr17:47447950 C/A cg11430096 chr6:110968061 CDK19 0.68 6.0 0.31 5.08e-9 Prostate cancer; CRC cis rs2276314 0.857 rs62101379 chr18:33584902 G/A cg05985134 chr18:33552581 C18orf21 0.49 6.46 0.34 3.81e-10 Endometriosis;Drug-induced torsades de pointes; CRC cis rs72781680 0.784 rs12616678 chr2:24181159 G/T cg08917208 chr2:24149416 ATAD2B 0.57 6.82 0.35 4.39e-11 Lymphocyte counts; CRC cis rs2019137 0.936 rs12612729 chr2:113957048 G/A cg21550016 chr2:113992930 PAX8;LOC440839;LOC654433 -0.51 -7.29 -0.37 2.32e-12 Lymphocyte counts; CRC cis rs1552244 0.938 rs7647987 chr3:10140696 A/G cg10729496 chr3:10149963 C3orf24 0.49 6.78 0.35 5.57e-11 Alzheimer's disease; CRC cis rs28386778 0.897 rs6504187 chr17:61917099 G/A cg06873352 chr17:61820015 STRADA 0.79 14.89 0.63 1.12e-38 Prudent dietary pattern; CRC cis rs3733585 0.673 rs10018204 chr4:9964570 C/T cg11266682 chr4:10021025 SLC2A9 -0.47 -9.67 -0.47 1.2e-19 Cleft plate (environmental tobacco smoke interaction); CRC cis rs614226 1.000 rs7174 chr12:121017171 A/G cg27489772 chr12:121021490 NA 0.5 6.81 0.35 4.54e-11 Type 1 diabetes nephropathy; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg04971418 chr5:93954596 C5orf36;ANKRD32 0.38 6.06 0.32 3.67e-9 Liver disease severity in Alagille syndrome; CRC cis rs9611565 0.921 rs761366 chr22:41744022 C/G cg06634786 chr22:41940651 POLR3H -0.56 -6.75 -0.35 6.64e-11 Vitiligo; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg01364968 chr1:50834303 NA 0.39 6.24 0.33 1.33e-9 Liver disease severity in Alagille syndrome; CRC cis rs2180341 1.000 rs2057223 chr6:127637374 T/C cg24812749 chr6:127587940 RNF146 0.94 13.62 0.6 8.18e-34 Breast cancer; CRC cis rs10504229 0.593 rs58647001 chr8:58025132 G/A cg02290350 chr8:58132656 NA -0.39 -5.73 -0.3 2.29e-8 Developmental language disorder (linguistic errors); CRC cis rs28386778 0.787 rs2665827 chr17:61961350 G/C cg00280220 chr17:61926910 NA 0.35 5.77 0.3 1.83e-8 Prudent dietary pattern; CRC cis rs2786111 0.809 rs482526 chr1:197268763 A/C cg13682187 chr1:196946512 CFHR5 0.29 5.69 0.3 2.89e-8 Lupus nephritis in systemic lupus erythematosus; CRC cis rs734999 0.505 rs10797437 chr1:2539006 T/C cg20673091 chr1:2541236 MMEL1 0.36 5.9 0.31 8.92e-9 Ulcerative colitis; CRC cis rs926938 0.527 rs360667 chr1:115481451 C/G cg12756093 chr1:115239321 AMPD1 -0.49 -7.15 -0.37 5.69e-12 Autism; CRC cis rs2032447 0.966 rs7756117 chr6:26046565 A/G cg04800585 chr6:26043546 HIST1H2BB -0.51 -7.84 -0.4 6.28e-14 Intelligence (multi-trait analysis); CRC cis rs6545883 0.831 rs1186704 chr2:61672991 A/G cg15711740 chr2:61764176 XPO1 -0.45 -5.91 -0.31 8.59e-9 Tuberculosis; CRC cis rs3820068 0.705 rs7533125 chr1:15883744 T/C cg27534772 chr1:16042836 PLEKHM2 0.45 7.5 0.38 6.07e-13 Systolic blood pressure; CRC cis rs11976180 0.517 rs6949375 chr7:143773851 T/G cg10928931 chr7:144051247 ARHGEF5 0.48 5.89 0.31 9.79e-9 Obesity-related traits; CRC cis rs12545109 0.800 rs2670053 chr8:57421998 A/T cg09654669 chr8:57350985 NA -0.46 -7.31 -0.37 2.1e-12 Obesity-related traits; CRC cis rs561341 0.709 rs11542477 chr17:30185892 A/G cg12193833 chr17:30244370 NA 0.6 6.96 0.36 1.8e-11 Hip circumference adjusted for BMI; CRC cis rs1862618 0.802 rs194058 chr5:56188977 G/A cg18230493 chr5:56204884 C5orf35 -0.76 -9.41 -0.46 9.04e-19 Initial pursuit acceleration; CRC cis rs10256972 0.552 rs2960830 chr7:1200641 T/C cg23978390 chr7:1156363 C7orf50 0.47 6.49 0.34 3.13e-10 Longevity;Endometriosis; CRC cis rs61996546 0.622 rs12901528 chr15:26869399 T/C cg15066197 chr15:26874202 GABRB3 -0.39 -5.99 -0.31 5.37e-9 Response to methotrexate in juvenile idiopathic arthritis; CRC cis rs4665809 0.590 rs35532350 chr2:26441605 T/C cg27170947 chr2:26402098 FAM59B -0.59 -7.71 -0.39 1.53e-13 Gut microbiome composition (summer); CRC cis rs6951245 0.554 rs10246354 chr7:1132456 C/T cg04025307 chr7:1156635 C7orf50 0.71 8.84 0.44 5.91e-17 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC trans rs875971 0.660 rs2191268 chr7:66110224 C/T ch.12.61764592R chr12:63478325 NA -0.4 -6.27 -0.33 1.14e-9 Aortic root size; CRC cis rs17767392 0.958 rs2332638 chr14:72028915 A/G cg13720639 chr14:72061746 SIPA1L1 0.56 6.97 0.36 1.72e-11 Mitral valve prolapse; CRC cis rs58688157 0.705 rs936469 chr11:606749 G/A cg09218773 chr11:619014 MUPCDH -0.42 -6.15 -0.32 2.21e-9 Systemic lupus erythematosus; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg02226688 chr4:83351676 ENOPH1;HNRPDL 0.44 6.3 0.33 9.33e-10 Anxiety disorder; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg22980722 chr21:45719818 PFKL 0.38 6.08 0.32 3.3e-9 Liver disease severity in Alagille syndrome; CRC cis rs7147624 0.572 rs72714446 chr14:65933144 G/A cg03016385 chr14:66212404 NA 0.95 7.5 0.38 6.16e-13 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs2398893 1.000 rs2398893 chr9:96758342 A/G cg14459158 chr9:96720562 NA 0.44 7.31 0.37 2.11e-12 Waist-hip ratio;Waist-to-hip ratio adjusted for body mass index; CRC cis rs4862750 0.794 rs1030382 chr4:187903782 T/G cg03647317 chr4:187891568 NA -0.52 -9.19 -0.45 4.47e-18 Lobe attachment (rater-scored or self-reported); CRC cis rs6066835 1.000 rs6095272 chr20:47357517 A/G cg18078177 chr20:47281410 PREX1 0.65 6.05 0.32 4.01e-9 Multiple myeloma; CRC cis rs2836974 0.899 rs8127087 chr21:40544502 C/T cg17971929 chr21:40555470 PSMG1 0.81 11.76 0.54 6.78e-27 Cognitive function; CRC cis rs2439831 0.867 rs2920781 chr15:43924682 G/A cg02155558 chr15:43621948 ADAL;LCMT2 0.66 7.42 0.38 1.02e-12 Lung cancer in ever smokers; CRC cis rs7945705 0.719 rs2012680 chr11:8996059 G/A cg12365402 chr11:9010492 NRIP3 -0.61 -11.47 -0.53 7.75e-26 Hemoglobin concentration; CRC cis rs2839186 0.596 rs4819217 chr21:47644092 G/T cg09417038 chr21:47716443 C21orf57 -0.39 -6.37 -0.33 6.19e-10 Testicular germ cell tumor; CRC cis rs6951245 1.000 rs78158942 chr7:1090440 G/T cg03188948 chr7:1209495 NA 0.65 6.64 0.34 1.3e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs6500602 0.701 rs4786500 chr16:4525265 A/G cg14951292 chr16:4525986 HMOX2;NMRAL1 -0.73 -10.84 -0.51 1.31e-23 Schizophrenia; CRC cis rs56104184 0.775 rs73061689 chr19:49397214 C/T cg21252483 chr19:49399788 TULP2 -0.43 -6.62 -0.34 1.49e-10 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; CRC cis rs2742417 0.603 rs2742395 chr3:45758595 A/G cg04837898 chr3:45731254 SACM1L -0.47 -7.51 -0.38 5.66e-13 Response to anti-depressant treatment in major depressive disorder; CRC cis rs4665809 0.590 rs7260 chr2:26413917 C/T cg25036284 chr2:26402008 FAM59B -0.63 -8.36 -0.42 1.83e-15 Gut microbiome composition (summer); CRC trans rs7618501 0.635 rs34080578 chr3:50026029 A/C cg21659725 chr3:3221576 CRBN 0.61 9.59 0.47 2.31e-19 Intelligence (multi-trait analysis); CRC cis rs11098499 0.913 rs10010696 chr4:120164303 T/C cg24375607 chr4:120327624 NA 0.44 6.74 0.35 7e-11 Corneal astigmatism; CRC cis rs75422866 0.867 rs73102195 chr12:48060092 C/T cg14736327 chr12:48174669 SLC48A1 -0.79 -6.01 -0.31 4.92e-9 Pneumonia; CRC cis rs7617773 0.817 rs6787500 chr3:48299439 T/C cg11946769 chr3:48343235 NME6 0.55 7.95 0.4 2.97e-14 Coronary artery disease; CRC cis rs9814567 0.929 rs2241556 chr3:134183312 C/T cg06109529 chr3:134205091 CEP63;ANAPC13 0.8 11.55 0.54 3.95e-26 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs113601626 1 rs113601626 chr2:24239189 T/TCCTGGC cg08917208 chr2:24149416 ATAD2B 0.99 9.54 0.47 3.31e-19 Lymphocyte percentage of white cells; CRC cis rs798554 0.797 rs798487 chr7:2802943 G/A cg19346786 chr7:2764209 NA -0.41 -6.97 -0.36 1.73e-11 Height; CRC cis rs2971970 0.519 rs10246171 chr7:133633228 T/C cg03336402 chr7:133662267 EXOC4 0.63 9.63 0.47 1.65e-19 Intelligence (multi-trait analysis); CRC cis rs1552244 1.000 rs9811771 chr3:10133949 A/G cg18598329 chr3:10140678 FANCD2;C3orf24 -0.9 -12.91 -0.58 3.99e-31 Alzheimer's disease; CRC trans rs875971 0.660 rs2191268 chr7:66110224 C/T cg16307860 chr1:222886951 C1orf58;AIDA -0.38 -6.18 -0.32 1.94e-9 Aortic root size; CRC cis rs7909074 0.832 rs10793564 chr10:45386352 C/A cg05187965 chr10:45406764 TMEM72 -0.37 -8.48 -0.42 7.66e-16 Mean corpuscular volume; CRC cis rs7617480 0.648 rs14018 chr3:48784270 G/A cg20833759 chr3:49053208 WDR6;DALRD3 0.76 10.65 0.51 5.76e-23 Subjective well-being (multi-trait analysis);Menarche (age at onset); CRC cis rs740698 0.529 rs9895414 chr17:60793399 A/C cg20935293 chr17:60842802 MARCH10 -0.34 -6.02 -0.32 4.61e-9 Pulse pressure; CRC cis rs12586317 0.547 rs10142667 chr14:35445090 A/G cg16230307 chr14:35515116 FAM177A1 0.88 10.14 0.49 3.35e-21 Psoriasis; CRC cis rs1499614 0.803 rs1796229 chr7:66119661 G/A cg12463550 chr7:65579703 CRCP 0.64 5.86 0.31 1.12e-8 Gout; CRC cis rs1348850 0.958 rs10930799 chr2:178459325 G/C cg02961200 chr2:178257176 LOC100130691;AGPS 0.48 6.96 0.36 1.85e-11 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs4820539 1.000 rs4822358 chr22:23474795 A/G cg14186256 chr22:23484241 RTDR1 0.93 18.42 0.71 1.44e-52 Bone mineral density; CRC cis rs10804591 0.666 rs2811460 chr3:129306067 G/C cg21885638 chr3:129306552 PLXND1 -0.4 -5.99 -0.31 5.59e-9 Waist-hip ratio;Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Hip circumference adjusted for BMI;Waist-to-hip ratio adjusted for body mass index; CRC cis rs2836974 0.584 rs7276774 chr21:40628725 T/G cg06238570 chr21:40685208 BRWD1 -0.81 -12.99 -0.58 1.93e-31 Cognitive function; CRC cis rs1707322 0.752 rs11211147 chr1:46110094 A/G cg06784218 chr1:46089804 CCDC17 0.65 12.4 0.56 3.08e-29 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC trans rs2727020 0.894 rs11040333 chr11:49346332 G/A cg15704280 chr7:45808275 SEPT13 -0.76 -10.21 -0.49 1.99e-21 Coronary artery disease; CRC cis rs1862618 0.853 rs10461617 chr5:56104308 A/G cg24531977 chr5:56204891 C5orf35 -0.83 -11.34 -0.53 2.3e-25 Initial pursuit acceleration; CRC cis rs28386778 0.897 rs1877318 chr17:61819960 G/A cg25654072 chr17:61904446 PSMC5;FTSJ3 0.71 11.02 0.52 2.94e-24 Prudent dietary pattern; CRC cis rs9291683 0.679 rs3756225 chr4:10094133 G/C cg11266682 chr4:10021025 SLC2A9 -0.45 -9.1 -0.45 9.04e-18 Bone mineral density; CRC cis rs7727544 0.735 rs272884 chr5:131668654 G/C cg12564285 chr5:131593104 PDLIM4 0.31 5.64 0.3 3.69e-8 Blood metabolite levels; CRC trans rs9914544 0.545 rs8071783 chr17:18807939 C/G cg21372672 chr17:16614065 CCDC144A -0.39 -6.3 -0.33 9.69e-10 Educational attainment (years of education); CRC cis rs28386778 0.897 rs8066754 chr17:61816590 T/C cg06601766 chr17:61851465 DDX42;CCDC47 0.43 5.85 0.31 1.21e-8 Prudent dietary pattern; CRC cis rs4730250 0.707 rs78472146 chr7:106967491 C/A cg02696742 chr7:106810147 HBP1 -0.58 -6.28 -0.33 1.08e-9 Osteoarthritis; CRC cis rs10242455 0.702 rs76840929 chr7:98945858 T/C cg18809830 chr7:99032528 PTCD1 -1.05 -7.58 -0.39 3.58e-13 Blood metabolite levels; CRC cis rs4665809 1.000 rs4233710 chr2:26291565 G/A cg26119090 chr2:26468346 HADHA;HADHB -0.65 -7.95 -0.4 2.98e-14 Gut microbiome composition (summer); CRC cis rs9463078 0.625 rs538801 chr6:44875762 A/T cg25276700 chr6:44698697 NA 0.25 6.12 0.32 2.64e-9 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; CRC cis rs6570726 0.791 rs6902410 chr6:145905261 G/A cg05347473 chr6:146136440 FBXO30 0.38 5.8 0.3 1.54e-8 Lobe attachment (rater-scored or self-reported); CRC cis rs9814567 0.896 rs1357764 chr3:134344928 T/G cg06109529 chr3:134205091 CEP63;ANAPC13 0.68 9.79 0.48 4.84e-20 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs6502050 0.835 rs8065210 chr17:80090960 G/A cg11859384 chr17:80120422 CCDC57 -0.38 -5.98 -0.31 5.84e-9 Life satisfaction; CRC cis rs12908161 1.000 rs12908161 chr15:85207825 A/G cg11189052 chr15:85197271 WDR73 0.61 8.67 0.43 2.03e-16 Schizophrenia; CRC trans rs11466653 1.000 rs10856840 chr4:38777383 G/A cg11403706 chr22:49042600 FAM19A5 0.62 6.11 0.32 2.76e-9 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs1577917 0.958 rs10455448 chr6:86533611 T/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.49 -6.58 -0.34 1.82e-10 Response to antipsychotic treatment; CRC cis rs7914558 0.966 rs56946876 chr10:104653545 T/C cg15744005 chr10:104629667 AS3MT -0.33 -7.19 -0.37 4.36e-12 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs2859741 0.528 rs59729868 chr1:37493710 G/A cg09363841 chr1:37513479 NA -0.45 -7.02 -0.36 1.28e-11 Forced expiratory volume in 1 second (environmental tobacco smoke interaction); CRC cis rs8062405 0.723 rs12445744 chr16:28588395 A/C cg16576597 chr16:28551801 NUPR1 0.56 8.39 0.42 1.42e-15 Cognitive ability (multi-trait analysis);Cognitive ability; CRC cis rs6500602 0.787 rs7204624 chr16:4459834 A/G cg14951292 chr16:4525986 HMOX2;NMRAL1 0.67 8.61 0.43 3.13e-16 Schizophrenia; CRC trans rs875971 0.660 rs2191268 chr7:66110224 C/T cg02401792 chr22:46664110 TTC38 -0.4 -6.49 -0.34 3.24e-10 Aortic root size; CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg17976829 chr10:131934431 GLRX3 -0.5 -6.32 -0.33 8.35e-10 Diisocyanate-induced asthma; CRC cis rs6076065 0.723 rs4813493 chr20:23367373 G/C cg11657817 chr20:23433608 CST11 0.45 6.69 0.35 9.76e-11 Facial morphology (factor 15, philtrum width); CRC trans rs12478296 1.000 rs73007140 chr2:243010756 T/C cg06834434 chr14:75079333 LTBP2 0.54 6.81 0.35 4.71e-11 Obesity-related traits; CRC cis rs7680126 0.500 rs11735668 chr4:10148655 C/G cg11266682 chr4:10021025 SLC2A9 -0.44 -6.15 -0.32 2.3e-9 Urate levels in lean individuals;Urate levels in overweight individuals;Urate levels in obese individuals; CRC cis rs7811142 1.000 rs11761784 chr7:100039970 C/T cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.89 12.33 0.56 5.45e-29 Platelet count; CRC trans rs2243480 1.000 rs431076 chr7:65600320 A/C cg10756647 chr7:56101905 PSPH 0.74 7.72 0.39 1.43e-13 Diabetic kidney disease; CRC cis rs12291225 0.679 rs11238 chr11:14288128 A/C cg19336497 chr11:14380999 RRAS2 0.51 8.52 0.43 5.94e-16 Sense of smell; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg02403294 chr22:38795347 LOC400927 0.41 5.98 0.31 5.97e-9 Liver disease severity in Alagille syndrome; CRC cis rs1538970 0.884 rs781226 chr1:45872662 T/C cg05343316 chr1:45956843 TESK2 -0.64 -8.78 -0.44 9.15e-17 Platelet count; CRC trans rs2303319 0.504 rs72877343 chr2:162607487 A/C cg22677401 chr17:46026860 NA -0.67 -6.07 -0.32 3.57e-9 Cognitive function; CRC cis rs17162190 0.698 rs12045800 chr1:26845366 A/G cg17456097 chr1:26900765 RPS6KA1 0.41 5.67 0.3 3.09e-8 Mean corpuscular volume; CRC cis rs4713118 0.869 rs9283880 chr6:27715243 A/C cg19041857 chr6:27730383 NA -0.41 -5.96 -0.31 6.46e-9 Parkinson's disease; CRC cis rs8177253 0.829 rs9882812 chr3:133506127 A/G cg01448562 chr3:133502909 NA -0.69 -12.26 -0.56 1.02e-28 Iron status biomarkers; CRC cis rs972578 1.000 rs2068943 chr22:43356311 C/T cg01576275 chr22:43409880 NA -0.45 -7.32 -0.37 1.95e-12 Mean platelet volume; CRC cis rs7412746 0.658 rs72704685 chr1:150897687 C/G cg18016565 chr1:150552671 MCL1 0.42 6.06 0.32 3.63e-9 Melanoma; CRC cis rs2836974 0.897 rs2836933 chr21:40564202 C/G cg06238570 chr21:40685208 BRWD1 0.78 10.62 0.51 7.81e-23 Cognitive function; CRC cis rs1448094 0.545 rs11117077 chr12:86277317 A/G cg02569458 chr12:86230093 RASSF9 0.38 6.29 0.33 9.9e-10 Major depressive disorder; CRC cis rs7671266 0.518 rs16895984 chr4:10284727 C/T cg00071950 chr4:10020882 SLC2A9 0.39 6.31 0.33 8.81e-10 Cardiovascular disease risk factors; CRC trans rs2303319 0.504 rs1449641 chr2:162619567 T/C cg20024234 chr21:43431083 ZNF295 -0.66 -5.96 -0.31 6.5e-9 Cognitive function; CRC trans rs12310956 0.532 rs1525897 chr12:33941033 C/T cg26384229 chr12:38710491 ALG10B 0.49 6.2 0.32 1.73e-9 Morning vs. evening chronotype; CRC cis rs7527798 0.592 rs11118360 chr1:207858586 G/A cg09232269 chr1:207846808 CR1L -0.44 -7.01 -0.36 1.35e-11 Erythrocyte sedimentation rate; CRC cis rs7178572 0.568 rs12901739 chr15:77395491 C/T cg22256960 chr15:77711686 NA -0.63 -8.96 -0.44 2.45e-17 Type 2 diabetes; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg23036426 chr1:10093530 UBE4B 0.45 6.05 0.32 3.93e-9 Thyroid stimulating hormone; CRC cis rs780096 0.546 rs1647284 chr2:27608115 C/T cg27432699 chr2:27873401 GPN1 -0.5 -7.56 -0.38 4.14e-13 Total body bone mineral density; CRC trans rs2303319 0.504 rs62189052 chr2:162623869 C/G cg04551154 chr10:95462393 C10orf4 -0.74 -6.34 -0.33 7.76e-10 Cognitive function; CRC cis rs1401999 1.000 rs10937158 chr3:183708439 T/C cg20387954 chr3:183756860 HTR3D 0.45 7.64 0.39 2.47e-13 Anterior chamber depth; CRC cis rs642858 1.000 rs623331 chr6:140284946 C/T cg27524944 chr6:140295369 NA 0.35 5.89 0.31 9.33e-9 Type 2 diabetes; CRC cis rs9399135 0.967 rs6923765 chr6:135335176 C/G cg22676075 chr6:135203613 NA -0.43 -6.64 -0.34 1.3e-10 Red blood cell count; CRC cis rs34779708 0.897 rs11010131 chr10:35513316 A/C cg03585969 chr10:35415529 CREM 0.56 7.51 0.38 5.59e-13 Inflammatory bowel disease;Crohn's disease; CRC cis rs763014 1.000 rs2269558 chr16:682250 C/T cg10096052 chr16:615709 NHLRC4 -0.34 -5.65 -0.3 3.49e-8 Height; CRC cis rs7044106 0.512 rs7873848 chr9:123354222 C/G cg09419670 chr9:123605666 PSMD5;LOC253039 0.64 10.1 0.49 4.49e-21 Hip circumference adjusted for BMI; CRC trans rs11227306 0.934 rs10896056 chr11:65587905 A/G cg17712092 chr4:129076599 LARP1B 0.52 6.86 0.35 3.39e-11 DNA methylation (variation); CRC cis rs9420 0.961 rs17455520 chr11:57540458 C/A cg23127183 chr11:57508653 C11orf31 -0.52 -7.12 -0.37 6.68e-12 Schizophrenia; CRC cis rs3741404 0.560 rs7938819 chr11:63910116 G/A cg18225595 chr11:63971243 STIP1 -0.52 -8.51 -0.42 6.46e-16 Platelet count; CRC cis rs10752881 1.000 rs8179283 chr1:182974602 C/T ch.1.3577855R chr1:183094577 LAMC1 0.87 15.17 0.64 8.98e-40 Colorectal cancer; CRC cis rs1348850 0.872 rs4893825 chr2:178298687 A/G cg22681709 chr2:178499509 PDE11A -0.39 -7.13 -0.37 6.26e-12 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs1218582 0.682 rs12144978 chr1:154850445 G/A cg06221963 chr1:154839813 KCNN3 -0.83 -15.34 -0.65 1.91e-40 Prostate cancer; CRC cis rs11583043 1.000 rs7535068 chr1:101490329 T/G cg16556008 chr1:101360663 SLC30A7;EXTL2 0.45 5.76 0.3 1.89e-8 Ulcerative colitis;Inflammatory bowel disease; CRC cis rs736408 0.812 rs9324 chr3:52825585 T/C cg18404041 chr3:52824283 ITIH1 -0.48 -9.93 -0.48 1.76e-20 Bipolar disorder; CRC cis rs7254114 0.578 rs35248735 chr19:11312238 G/A cg02815516 chr19:11306319 KANK2 -0.33 -6.27 -0.33 1.11e-9 Immature fraction of reticulocytes; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg17216600 chr6:52442344 TRAM2 0.41 6.85 0.35 3.64e-11 Liver disease severity in Alagille syndrome; CRC trans rs7615952 0.546 rs2979307 chr3:125309574 C/T cg21747405 chr11:67723411 NA 0.46 6.11 0.32 2.86e-9 Blood pressure (smoking interaction); CRC cis rs3823572 0.564 rs2971973 chr7:133644256 G/A cg03336402 chr7:133662267 EXOC4 -0.67 -10.4 -0.5 4.3e-22 Intelligence (multi-trait analysis); CRC cis rs7091068 0.522 rs866674 chr10:95487515 A/G cg20715218 chr10:95462985 C10orf4 0.45 5.63 0.3 3.92e-8 Urinary tract infection frequency; CRC trans rs11098499 0.505 rs75122014 chr4:120362426 G/C cg25214090 chr10:38739885 LOC399744 0.66 10.47 0.5 2.41e-22 Corneal astigmatism; CRC cis rs561341 0.710 rs9900031 chr17:30199537 T/C cg13647721 chr17:30228624 UTP6 -0.61 -6.48 -0.34 3.38e-10 Hip circumference adjusted for BMI; CRC cis rs2404602 1.000 rs11072603 chr15:76881138 G/T cg23625390 chr15:77176239 SCAPER 0.58 8.75 0.43 1.1e-16 Blood metabolite levels; CRC cis rs17152411 1.000 rs7089014 chr10:126590342 G/A cg07906193 chr10:126599966 NA 0.58 6.52 0.34 2.69e-10 Height; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg14654948 chr6:36164803 BRPF3 0.38 6.25 0.33 1.26e-9 Liver disease severity in Alagille syndrome; CRC cis rs12477438 0.501 rs2632284 chr2:99775865 C/G cg26064155 chr2:99771622 LIPT1;TSGA10 0.88 16.24 0.67 5.59e-44 Chronic sinus infection; CRC cis rs4853012 0.838 rs6715351 chr2:74346119 G/A cg05890377 chr2:74357713 NA 0.59 9.8 0.48 4.57e-20 Gestational age at birth (maternal effect); CRC trans rs7395662 1.000 rs4882016 chr11:48570125 G/A cg21153622 chr11:89784906 NA -0.44 -7.11 -0.36 7.07e-12 HDL cholesterol; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg03356490 chr19:35605867 FXYD3 0.37 6.12 0.32 2.63e-9 Liver disease severity in Alagille syndrome; CRC cis rs4664293 1.000 rs6432540 chr2:160450703 G/A cg08347373 chr2:160653686 CD302 -0.37 -6.03 -0.32 4.29e-9 Monocyte percentage of white cells; CRC cis rs7666738 0.791 rs2081622 chr4:98927369 T/C cg05340658 chr4:99064831 C4orf37 0.6 9.35 0.46 1.41e-18 Colonoscopy-negative controls vs population controls; CRC cis rs9916302 0.680 rs2271308 chr17:37817482 T/C cg15445000 chr17:37608096 MED1 0.27 5.88 0.31 9.93e-9 Glomerular filtration rate (creatinine); CRC trans rs2727020 0.635 rs7124266 chr11:49280857 T/G cg15704280 chr7:45808275 SEPT13 0.69 9.64 0.47 1.55e-19 Coronary artery disease; CRC cis rs7772486 0.742 rs4896851 chr6:146278959 T/C cg23711669 chr6:146136114 FBXO30 -0.62 -10.47 -0.5 2.5e-22 Lobe attachment (rater-scored or self-reported); CRC cis rs4664293 0.625 rs62171646 chr2:160519074 A/C cg08347373 chr2:160653686 CD302 0.39 6.58 0.34 1.91e-10 Monocyte percentage of white cells; CRC cis rs1005277 0.579 rs1780138 chr10:38501654 A/G cg03665457 chr10:38645376 HSD17B7P2 -0.42 -5.97 -0.31 6.02e-9 Extrinsic epigenetic age acceleration; CRC cis rs9916302 0.768 rs11078900 chr17:37614641 C/T cg03013999 chr17:37608204 MED1 0.45 6.85 0.35 3.64e-11 Glomerular filtration rate (creatinine); CRC cis rs2153535 0.580 rs6597334 chr6:8504779 C/T cg07606381 chr6:8435919 SLC35B3 0.65 10.55 0.5 1.36e-22 Motion sickness; CRC cis rs2228479 0.850 rs11640188 chr16:89807732 C/T cg06656553 chr16:89960601 TCF25 -0.68 -5.71 -0.3 2.55e-8 Skin colour saturation; CRC cis rs7811142 0.830 rs11761253 chr7:99939321 C/T cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.89 11.62 0.54 2.18e-26 Platelet count; CRC cis rs950776 0.616 rs495090 chr15:78870003 A/G cg06917634 chr15:78832804 PSMA4 -0.55 -8.22 -0.41 4.76e-15 Sudden cardiac arrest; CRC cis rs11764590 0.694 rs10276536 chr7:2086960 C/T cg23422044 chr7:1970798 MAD1L1 -0.44 -6.21 -0.32 1.58e-9 Neuroticism; CRC cis rs9527 0.571 rs3740400 chr10:104629465 T/G cg04362960 chr10:104952993 NT5C2 0.6 8.47 0.42 8.28e-16 Arsenic metabolism; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg04272256 chr20:17949548 C20orf72;SNX5 0.45 6.31 0.33 9.13e-10 Anxiety disorder; CRC cis rs11758351 1.000 rs77957229 chr6:26185226 A/G cg16070018 chr6:26224392 HIST1H3E 0.58 5.8 0.3 1.54e-8 Gout;Renal underexcretion gout; CRC cis rs7809950 0.678 rs13230144 chr7:106909172 T/C cg23024343 chr7:107201750 COG5 -0.73 -10.11 -0.49 4.3e-21 Coronary artery disease; CRC cis rs55882075 0.967 rs12656648 chr5:179152106 C/A cg14593053 chr5:179126677 CANX 0.48 7.53 0.38 4.91e-13 Monocyte percentage of white cells; CRC cis rs6963495 0.818 rs1721498 chr7:105178819 A/C cg19920283 chr7:105172520 RINT1 -0.54 -6.72 -0.35 8.22e-11 Bipolar disorder (body mass index interaction); CRC cis rs754466 0.561 rs11002344 chr10:79709725 A/T cg17075019 chr10:79541650 NA -0.6 -6.88 -0.35 2.96e-11 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs9660992 0.573 rs1172158 chr1:205208948 G/A cg21643547 chr1:205240462 TMCC2 -0.38 -6.08 -0.32 3.27e-9 Mean corpuscular volume;Mean platelet volume; CRC cis rs10189230 0.967 rs13026659 chr2:222353014 C/T cg14652038 chr2:222343519 EPHA4 0.51 9.76 0.47 6.42e-20 Urate levels in lean individuals; CRC trans rs7726839 0.574 rs12517345 chr5:628294 G/A cg11887960 chr12:57824829 NA 0.59 6.57 0.34 2e-10 Obesity-related traits; CRC cis rs2224391 1.000 rs2224391 chr6:5260936 A/C cg09085698 chr6:5261316 LYRM4;FARS2 -0.43 -5.69 -0.3 2.8e-8 Height; CRC cis rs477692 0.637 rs10829598 chr10:131319774 C/G cg05714579 chr10:131428358 MGMT 0.5 6.99 0.36 1.54e-11 Response to temozolomide; CRC cis rs873946 0.529 rs12258248 chr10:134573767 A/G cg27286337 chr10:134555280 INPP5A 0.65 8.54 0.43 5.01e-16 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CRC trans rs7615952 0.546 rs16836896 chr3:125311262 A/T cg00769240 chr8:12517080 NA -0.59 -6.39 -0.33 5.53e-10 Blood pressure (smoking interaction); CRC cis rs8044995 0.563 rs2279540 chr16:68395061 T/C cg05110241 chr16:68378359 PRMT7 -0.75 -7.75 -0.39 1.14e-13 Schizophrenia; CRC cis rs10206020 0.921 rs72778005 chr2:1573122 C/G cg26248373 chr2:1572462 NA -0.83 -12.14 -0.56 2.9e-28 IgG glycosylation; CRC cis rs10760158 0.832 rs880823 chr9:124038467 C/A cg14417974 chr9:124058376 GSN -0.35 -5.89 -0.31 9.54e-9 Pulse pressure; CRC cis rs8060686 0.641 rs76501820 chr16:68114582 G/A cg26727032 chr16:67993705 SLC12A4 -0.6 -6.81 -0.35 4.79e-11 HDL cholesterol;Metabolic syndrome; CRC cis rs1552244 0.882 rs13066757 chr3:10045030 C/A cg02579736 chr3:10068473 FANCD2;CIDECP 0.96 12.45 0.57 1.96e-29 Alzheimer's disease; CRC cis rs6121246 0.697 rs6060912 chr20:30325755 C/A cg18721089 chr20:30220636 NA -0.36 -5.86 -0.31 1.12e-8 Mean corpuscular hemoglobin; CRC cis rs6963495 0.818 rs75116202 chr7:105160059 C/T cg02135003 chr7:105160482 PUS7 -0.9 -12.2 -0.56 1.71e-28 Bipolar disorder (body mass index interaction); CRC cis rs6951245 0.872 rs75280240 chr7:1058511 C/T cg22907277 chr7:1156413 C7orf50 0.69 7.23 0.37 3.39e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg21365899 chr1:231558446 EGLN1 0.54 7.96 0.4 2.83e-14 Response to antipsychotic treatment; CRC cis rs7605827 0.866 rs7598936 chr2:15597289 A/G cg19274914 chr2:15703543 NA 0.39 6.0 0.31 5.11e-9 Educational attainment (years of education); CRC cis rs7412746 0.658 rs10305704 chr1:150804429 A/C cg10589385 chr1:150898437 SETDB1 0.31 6.35 0.33 7.02e-10 Melanoma; CRC cis rs12134245 0.776 rs6688261 chr1:91987034 C/T cg07090678 chr1:91966139 CDC7 0.35 5.86 0.31 1.14e-8 Breast cancer; CRC cis rs10504229 0.639 rs2291764 chr8:58142943 A/C cg02290350 chr8:58132656 NA -0.6 -6.97 -0.36 1.69e-11 Developmental language disorder (linguistic errors); CRC cis rs7121446 0.521 rs11218490 chr11:121862691 A/G cg13820391 chr11:121835505 NA 0.33 5.99 0.31 5.52e-9 Cardiovascular risk factors (age interaction); CRC cis rs7552404 0.889 rs1250874 chr1:76190978 A/G cg22875332 chr1:76189707 ACADM 0.69 10.77 0.51 2.35e-23 Blood metabolite levels;Acylcarnitine levels; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg15356780 chr14:90422831 TDP1 0.47 6.59 0.34 1.7e-10 Response to antipsychotic treatment; CRC cis rs727479 0.523 rs8034835 chr15:51512664 A/G cg19946085 chr15:51559439 CYP19A1 -0.31 -6.4 -0.33 5.36e-10 Estradiol levels; CRC trans rs2321882 0.794 rs12427445 chr13:59477563 G/T cg04268950 chr11:130298854 ADAMTS8 -0.45 -5.99 -0.31 5.64e-9 Body mass index; CRC cis rs7481584 0.581 rs105686 chr11:3062467 G/A cg25174290 chr11:3078921 CARS -0.43 -5.98 -0.31 5.86e-9 Calcium levels; CRC cis rs9611565 0.512 rs5758439 chr22:42131762 C/T cg06634786 chr22:41940651 POLR3H 0.68 7.6 0.39 3.04e-13 Vitiligo; CRC trans rs1005277 0.579 rs2505198 chr10:38393183 A/C cg11292332 chr7:45801988 SEPT13 -0.35 -6.33 -0.33 7.9e-10 Extrinsic epigenetic age acceleration; CRC cis rs6860806 0.631 rs4705931 chr5:131588345 T/C cg09877947 chr5:131593287 PDLIM4 0.47 8.75 0.43 1.14e-16 Breast cancer; CRC cis rs6964587 1.000 rs13231238 chr7:91653851 T/G cg17063962 chr7:91808500 NA 0.8 14.2 0.62 5.1e-36 Breast cancer; CRC trans rs13046373 0.905 rs4816372 chr21:32077414 A/T cg19350133 chr12:3948413 PARP11 -0.38 -6.04 -0.32 4.2e-9 HDL cholesterol; CRC cis rs9341808 1.000 rs1359239 chr6:80956146 G/A cg08355045 chr6:80787529 NA 0.38 6.5 0.34 2.96e-10 Sitting height ratio; CRC cis rs1348850 0.831 rs1345139 chr2:178449791 G/GT cg05169160 chr2:178484487 TTC30A -0.64 -5.7 -0.3 2.66e-8 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs6930083 0.713 rs1321309 chr6:36638636 G/A cg08179530 chr6:36648295 CDKN1A -0.71 -11.61 -0.54 2.41e-26 Coronary artery disease; CRC cis rs270601 0.913 rs273899 chr5:131695178 G/A cg09877947 chr5:131593287 PDLIM4 0.43 7.01 0.36 1.33e-11 Acylcarnitine levels; CRC cis rs860295 0.702 rs56675301 chr1:155364327 T/C cg02153340 chr1:155202674 NA -0.57 -6.77 -0.35 5.96e-11 Body mass index; CRC cis rs10504229 0.953 rs67886764 chr8:58187117 T/C cg24829409 chr8:58192753 C8orf71 -0.68 -11.34 -0.53 2.27e-25 Developmental language disorder (linguistic errors); CRC cis rs1218582 0.774 rs4845683 chr1:154877407 T/C cg09359103 chr1:154839909 KCNN3 -0.74 -12.94 -0.58 3.16e-31 Prostate cancer; CRC cis rs875971 0.651 rs2420596 chr7:65915983 T/C cg11764359 chr7:65958608 NA 0.6 9.23 0.45 3.28e-18 Aortic root size; CRC cis rs853679 0.723 rs9366718 chr6:28205502 A/T cg06470822 chr6:28175283 NA 0.77 8.08 0.41 1.23e-14 Depression; CRC trans rs2692947 0.673 rs2917662 chr2:96794957 G/A cg09070855 chr12:133302174 NA 0.4 6.04 0.32 4.12e-9 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; CRC cis rs651907 0.514 rs12636047 chr3:101434449 T/C cg12386194 chr3:101231763 SENP7 0.49 7.12 0.37 6.68e-12 Colorectal cancer; CRC trans rs1814175 0.615 rs10839378 chr11:49806943 C/T cg15704280 chr7:45808275 SEPT13 -0.95 -16.68 -0.68 1.05e-45 Height; CRC cis rs10128251 0.650 rs4469789 chr10:5712366 A/G cg11519256 chr10:5708881 ASB13 0.58 7.89 0.4 4.38e-14 Childhood ear infection; CRC cis rs1707322 0.686 rs3014251 chr1:46077428 G/C cg03146154 chr1:46216737 IPP -0.68 -9.65 -0.47 1.42e-19 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs6582630 0.502 rs11181214 chr12:38298313 C/A cg13010199 chr12:38710504 ALG10B 0.46 6.25 0.33 1.3e-9 Drug-induced liver injury (flucloxacillin); CRC cis rs2404602 0.647 rs36114653 chr15:77025393 G/A cg03037974 chr15:76606532 NA -0.53 -7.67 -0.39 1.98e-13 Blood metabolite levels; CRC cis rs4664308 0.810 rs59019419 chr2:161061287 G/A cg03641300 chr2:160917029 PLA2R1 -0.71 -11.73 -0.54 8.64e-27 Idiopathic membranous nephropathy; CRC cis rs2933343 0.729 rs789230 chr3:128602558 G/A cg11901034 chr3:128598214 ACAD9 -0.55 -7.74 -0.39 1.2e-13 IgG glycosylation; CRC cis rs4664293 0.625 rs6707985 chr2:160516388 T/C cg08347373 chr2:160653686 CD302 0.39 6.58 0.34 1.91e-10 Monocyte percentage of white cells; CRC cis rs832540 0.552 rs702681 chr5:56218029 C/T cg24531977 chr5:56204891 C5orf35 -0.55 -8.42 -0.42 1.14e-15 Coronary artery disease; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg13571388 chr1:26947729 NA 0.47 6.35 0.33 7.32e-10 Anxiety disorder; CRC cis rs2295359 0.892 rs11209004 chr1:67613932 G/A cg03340356 chr1:67600835 NA 0.28 6.33 0.33 8.24e-10 Psoriasis; CRC cis rs7586673 0.893 rs889925 chr2:161971597 T/C cg22496339 chr2:162101262 NA 0.6 8.64 0.43 2.47e-16 Intelligence (multi-trait analysis); CRC cis rs1577917 0.570 rs114854865 chr6:86554236 A/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.51 -6.59 -0.34 1.76e-10 Response to antipsychotic treatment; CRC cis rs7949030 0.626 rs11231145 chr11:62328854 G/A cg13298116 chr11:62369859 EML3;MTA2 0.61 10.89 0.51 8.54e-24 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; CRC trans rs2727020 1.000 rs2727020 chr11:49111407 C/G cg15704280 chr7:45808275 SEPT13 0.65 8.87 0.44 4.91e-17 Coronary artery disease; CRC cis rs929354 0.772 rs7778193 chr7:156980087 C/T cg05182265 chr7:156933206 UBE3C -0.75 -14.14 -0.61 8.55e-36 Body mass index; CRC trans rs3849570 0.695 rs62265411 chr3:81573660 T/C cg23387109 chr10:94051229 MARCH5;CPEB3 0.46 6.16 0.32 2.1e-9 Waist circumference;Body mass index; CRC trans rs7395662 0.784 rs75694945 chr11:48865463 C/T cg21153622 chr11:89784906 NA 0.47 7.45 0.38 8.17e-13 HDL cholesterol; CRC cis rs7615952 0.673 rs7632557 chr3:125634881 G/C cg05084668 chr3:125655381 ALG1L -0.62 -8.37 -0.42 1.71e-15 Blood pressure (smoking interaction); CRC cis rs8031584 1.000 rs1474380 chr15:31269235 T/C cg08704250 chr15:31115839 NA -0.44 -8.3 -0.42 2.72e-15 Huntington's disease progression; CRC cis rs8072100 0.840 rs11079774 chr17:45479706 C/G cg08085267 chr17:45401833 C17orf57 -0.68 -11.16 -0.52 9.45e-25 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs13108904 0.935 rs11247984 chr4:1292811 G/A cg21620606 chr4:1342894 KIAA1530 0.34 5.65 0.3 3.53e-8 Obesity-related traits; CRC cis rs4862750 0.872 rs56389997 chr4:187894796 A/C cg22105103 chr4:187893119 NA 0.64 11.58 0.54 2.94e-26 Lobe attachment (rater-scored or self-reported); CRC cis rs1799949 0.965 rs11658499 chr17:41334749 C/T cg23758822 chr17:41437982 NA 0.81 13.66 0.6 5.58e-34 Menopause (age at onset); CRC trans rs1814175 0.645 rs1851853 chr11:49953434 C/T cg03929089 chr4:120376271 NA -0.91 -16.17 -0.67 1.06e-43 Height; CRC trans rs637571 0.546 rs10791827 chr11:65596546 C/A cg17712092 chr4:129076599 LARP1B -0.61 -9.32 -0.46 1.8e-18 Eosinophil percentage of white cells; CRC cis rs7617773 0.694 rs13099560 chr3:48204768 C/T cg11946769 chr3:48343235 NME6 -0.54 -7.74 -0.39 1.23e-13 Coronary artery disease; CRC cis rs11833313 1 rs11833313 chr12:110510470 A/G cg12870014 chr12:110450643 ANKRD13A 0.86 8.88 0.44 4.53e-17 Intelligence (multi-trait analysis); CRC cis rs6502050 0.835 rs7218857 chr17:80161000 T/C cg02741985 chr17:80059408 CCDC57 0.42 6.93 0.36 2.24e-11 Life satisfaction; CRC cis rs9325144 0.560 rs1601745 chr12:38647828 G/A cg26384229 chr12:38710491 ALG10B -0.5 -7.46 -0.38 7.68e-13 Morning vs. evening chronotype; CRC cis rs6701037 0.555 rs10912898 chr1:175120469 A/G cg00321850 chr1:175162397 KIAA0040 -0.38 -6.47 -0.34 3.46e-10 Alcohol dependence; CRC cis rs806795 0.525 rs12661552 chr6:26265200 G/A cg00631329 chr6:26305371 NA -0.53 -8.67 -0.43 2.05e-16 Mosquito bite size; CRC cis rs10504229 0.728 rs72650860 chr8:58153111 A/G cg02290350 chr8:58132656 NA -0.51 -6.57 -0.34 1.98e-10 Developmental language disorder (linguistic errors); CRC cis rs7945705 0.902 rs7479407 chr11:9023421 C/T cg14711859 chr11:8959438 ASCL3 -0.44 -7.07 -0.36 9.37e-12 Hemoglobin concentration; CRC cis rs1448094 0.511 rs2405616 chr12:86148042 A/G cg06740227 chr12:86229804 RASSF9 -0.37 -5.64 -0.3 3.71e-8 Major depressive disorder; CRC cis rs4481887 1.000 rs10888352 chr1:248451965 G/A cg00666640 chr1:248458726 OR2T12 0.55 9.69 0.47 1.1e-19 Common traits (Other); CRC cis rs4713118 0.662 rs9468274 chr6:28026077 G/T cg21251018 chr6:28226885 NKAPL 0.46 6.46 0.34 3.67e-10 Parkinson's disease; CRC cis rs9467773 1.000 rs9467783 chr6:26542894 C/T cg09904177 chr6:26538194 HMGN4 0.86 14.83 0.63 1.91e-38 Intelligence (multi-trait analysis); CRC cis rs2839186 0.632 rs2839184 chr21:47689013 G/A cg12516959 chr21:47718080 NA -0.46 -7.44 -0.38 8.93e-13 Testicular germ cell tumor; CRC cis rs6712932 1.000 rs1978821 chr2:105833235 C/T cg27422857 chr2:105853526 NA -0.31 -5.87 -0.31 1.06e-8 Type 2 diabetes; CRC cis rs1552244 0.554 rs34391585 chr3:9999208 G/C cg08888203 chr3:10149979 C3orf24 0.46 7.21 0.37 3.9e-12 Alzheimer's disease; CRC cis rs875971 0.862 rs778734 chr7:65814849 C/G cg12463550 chr7:65579703 CRCP 0.53 7.54 0.38 4.57e-13 Aortic root size; CRC cis rs7945705 0.776 rs2316865 chr11:8815470 A/G cg14711859 chr11:8959438 ASCL3 -0.37 -5.8 -0.3 1.57e-8 Hemoglobin concentration; CRC cis rs4494114 1.000 rs4388668 chr1:39360730 A/T cg25970120 chr1:39325951 RRAGC -0.42 -5.69 -0.3 2.76e-8 Blood protein levels; CRC cis rs720844 0.628 rs12616115 chr2:149298053 G/A cg09247360 chr2:149335327 NA -0.56 -5.83 -0.31 1.3e-8 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs3806843 0.838 rs2563289 chr5:140122766 T/A cg16607685 chr5:140181889 PCDHA2;PCDHA1;PCDHA3 0.26 6.15 0.32 2.29e-9 Depressive symptoms (multi-trait analysis); CRC cis rs6460942 0.915 rs79232243 chr7:12459494 G/A cg06484146 chr7:12443880 VWDE -0.78 -8.1 -0.41 1.11e-14 Coronary artery disease; CRC cis rs921968 0.565 rs13408305 chr2:219628183 G/A cg02176678 chr2:219576539 TTLL4 -0.39 -6.31 -0.33 8.79e-10 Mean corpuscular hemoglobin concentration; CRC cis rs2742417 0.603 rs6807438 chr3:45778623 G/A cg04837898 chr3:45731254 SACM1L -0.49 -7.88 -0.4 4.95e-14 Response to anti-depressant treatment in major depressive disorder; CRC trans rs2727020 0.729 rs1164685 chr11:49293660 G/A cg21153622 chr11:89784906 NA 0.42 6.83 0.35 3.99e-11 Coronary artery disease; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg08949862 chr2:63277672 OTX1 -0.39 -6.01 -0.31 4.82e-9 Myopia (pathological); CRC cis rs62402013 1 rs62402013 chr6:26915000 A/G cg18278486 chr6:26987575 LOC100270746;C6orf41 0.41 6.58 0.34 1.83e-10 Schizophrenia; CRC cis rs447 0.806 rs7808864 chr7:83723347 A/G cg22846510 chr7:83753280 SEMA3A -0.51 -6.71 -0.35 8.57e-11 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs17270561 0.609 rs9348695 chr6:25763010 A/T cg16482183 chr6:26056742 HIST1H1C 0.71 9.0 0.44 1.79e-17 Iron status biomarkers; CRC cis rs35306767 0.903 rs11253495 chr10:937064 C/T cg20503657 chr10:835505 NA 0.97 11.97 0.55 1.15e-27 Eosinophil percentage of granulocytes; CRC cis rs6964587 1.000 rs7455444 chr7:91639313 C/T cg17063962 chr7:91808500 NA 0.8 14.22 0.62 4.29e-36 Breast cancer; CRC cis rs739496 0.542 rs10219736 chr12:111788402 C/T cg10833066 chr12:111807467 FAM109A 0.54 7.08 0.36 8.98e-12 Platelet count; CRC cis rs73206853 0.544 rs55752061 chr12:111126096 G/C cg12870014 chr12:110450643 ANKRD13A 0.75 7.72 0.39 1.41e-13 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC cis rs7945705 0.747 rs2568045 chr11:9004060 T/C cg00186954 chr11:8933980 ST5;C11orf17 -0.46 -7.81 -0.4 7.68e-14 Hemoglobin concentration; CRC cis rs908922 0.887 rs1538084 chr1:152496012 A/C cg23254163 chr1:152506842 NA 0.42 7.12 0.37 7e-12 Hair morphology; CRC cis rs4819052 0.851 rs2838834 chr21:46665208 C/T cg11663144 chr21:46675770 NA -0.8 -13.55 -0.6 1.58e-33 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs853679 0.546 rs200996 chr6:27811828 G/A cg15845792 chr6:28175446 NA 0.73 6.48 0.34 3.27e-10 Depression; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg21528620 chr1:110753221 KCNC4 0.39 6.23 0.32 1.39e-9 Liver disease severity in Alagille syndrome; CRC cis rs8031584 0.918 rs34331396 chr15:31248736 C/G cg08109568 chr15:31115862 NA -0.54 -8.72 -0.43 1.36e-16 Huntington's disease progression; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg07176146 chr1:35325364 C1orf212 0.4 6.21 0.32 1.59e-9 Liver disease severity in Alagille syndrome; CRC cis rs478304 0.934 rs1193692 chr11:65504069 A/C cg27068330 chr11:65405492 SIPA1 0.43 6.35 0.33 7.22e-10 Acne (severe); CRC cis rs427394 0.632 rs2279656 chr5:6737576 G/A cg15145174 chr5:6755386 POLS -0.44 -6.49 -0.34 3.22e-10 Menopause (age at onset); CRC cis rs4808199 0.948 rs2301668 chr19:19452249 G/A cg03709012 chr19:19516395 GATAD2A 0.96 11.1 0.52 1.55e-24 Nonalcoholic fatty liver disease; CRC trans rs877282 0.945 rs34367686 chr10:791868 G/C cg22713356 chr15:30763199 NA 1.34 16.68 0.68 1.08e-45 Uric acid levels; CRC cis rs2658782 0.724 rs2658769 chr11:93252030 T/C cg15737290 chr11:93063684 CCDC67 0.57 7.88 0.4 4.96e-14 Pulmonary function decline; CRC cis rs7086627 0.515 rs10887895 chr10:82210011 A/G cg00277334 chr10:82204260 NA -0.84 -16.95 -0.68 9.58e-47 Post bronchodilator FEV1; CRC cis rs1552244 1.000 rs7652935 chr3:10151138 T/C cg18598329 chr3:10140678 FANCD2;C3orf24 -0.89 -11.93 -0.55 1.67e-27 Alzheimer's disease; CRC cis rs7532866 0.885 rs7520137 chr1:26731035 T/G cg17456097 chr1:26900765 RPS6KA1 -0.4 -6.01 -0.31 5.04e-9 Height; CRC cis rs6570726 0.791 rs7765675 chr6:145915077 A/C cg23711669 chr6:146136114 FBXO30 0.75 12.89 0.58 4.75e-31 Lobe attachment (rater-scored or self-reported); CRC cis rs11105298 0.891 rs3741898 chr12:89933763 G/C cg08166232 chr12:89918718 WDR51B;GALNT4 -0.59 -7.28 -0.37 2.51e-12 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; CRC cis rs9287719 0.967 rs6432114 chr2:10744930 C/T cg00105475 chr2:10696890 NA 0.45 7.21 0.37 3.91e-12 Prostate cancer; CRC cis rs748404 0.697 rs567357 chr15:43571390 C/G cg02155558 chr15:43621948 ADAL;LCMT2 0.44 6.55 0.34 2.15e-10 Lung cancer; CRC cis rs1059312 1.000 rs9738216 chr12:129281788 C/T cg09035930 chr12:129282057 SLC15A4 0.52 8.77 0.44 9.97e-17 Systemic lupus erythematosus; CRC cis rs1572438 1.000 rs873560 chr6:875559 A/G cg21062780 chr6:887772 NA -0.4 -6.14 -0.32 2.38e-9 Aging; CRC cis rs6460942 0.915 rs7803056 chr7:12306913 A/C cg20607287 chr7:12443886 VWDE -0.48 -6.32 -0.33 8.6e-10 Coronary artery disease; CRC cis rs801193 1.000 rs4717319 chr7:66242593 A/G cg00343986 chr7:65444356 GUSB 0.49 7.34 0.38 1.64e-12 Aortic root size; CRC cis rs875971 0.545 rs12673308 chr7:65631361 C/A cg03233332 chr7:66118400 NA -0.45 -6.22 -0.32 1.49e-9 Aortic root size; CRC cis rs10751667 0.666 rs4074234 chr11:977715 C/G ch.11.42038R chr11:967971 AP2A2 0.58 9.98 0.48 1.16e-20 Alzheimer's disease (late onset); CRC cis rs6952808 0.723 rs4721287 chr7:2028663 A/C cg22963979 chr7:1858916 MAD1L1 -0.53 -7.7 -0.39 1.66e-13 Bipolar disorder and schizophrenia; CRC cis rs4072705 0.646 rs915034 chr9:127244955 G/A cg13476313 chr9:127244764 NR5A1 0.28 5.65 0.3 3.5e-8 Menarche (age at onset); CRC cis rs7949030 0.620 rs2428551 chr11:62329758 T/A cg13298116 chr11:62369859 EML3;MTA2 0.58 10.44 0.5 3.03e-22 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; CRC trans rs12517041 1.000 rs10805749 chr5:23300740 T/C ch.8.1293020R chr8:59333349 UBXN2B -0.54 -5.96 -0.31 6.46e-9 Calcium levels; CRC cis rs10751667 0.666 rs7936830 chr11:959686 A/G cg01483505 chr11:975446 AP2A2 0.46 7.67 0.39 2.02e-13 Alzheimer's disease (late onset); CRC cis rs5758511 0.573 rs2284082 chr22:42240797 C/T cg00645731 chr22:42541494 CYP2D7P1 -0.35 -5.68 -0.3 2.9e-8 Birth weight; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg03352409 chr22:21336370 LZTR1 0.45 6.26 0.33 1.21e-9 Response to antipsychotic treatment; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg13964462 chr9:132389032 METTL11A 0.47 6.51 0.34 2.83e-10 Response to antipsychotic treatment; CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg19881050 chr20:32700182 EIF2S2 0.39 6.18 0.32 1.91e-9 Obesity-related traits; CRC cis rs1707322 0.682 rs12037459 chr1:46094959 T/G cg06784218 chr1:46089804 CCDC17 0.65 11.73 0.54 8.92e-27 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs7917772 0.503 rs10883732 chr10:104293461 G/A cg22532475 chr10:104410764 TRIM8 -0.36 -6.8 -0.35 5.08e-11 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC trans rs4843747 0.636 rs11117358 chr16:88105053 T/A cg26811252 chr16:29126840 RRN3P2 0.62 8.46 0.42 8.69e-16 Menopause (age at onset); CRC trans rs4478147 0.636 rs4552430 chr4:87434722 G/T cg01215037 chr19:50083917 PRRG2;NOSIP 0.45 5.99 0.31 5.58e-9 Migraine - clinic-based; CRC cis rs1035144 0.505 rs11159479 chr14:81460651 C/T cg06600135 chr14:81408086 NA -0.53 -7.89 -0.4 4.47e-14 Male sexual orientation; CRC cis rs11577318 0.812 rs3795683 chr1:26632831 C/A cg04990556 chr1:26633338 UBXN11 -0.48 -6.15 -0.32 2.31e-9 Granulocyte percentage of myeloid white cells; CRC cis rs72781680 0.898 rs72786278 chr2:24063243 C/T cg08917208 chr2:24149416 ATAD2B 0.93 9.53 0.47 3.63e-19 Lymphocyte counts; CRC cis rs7107174 1.000 rs2511158 chr11:77973980 C/T cg02023728 chr11:77925099 USP35 0.52 7.53 0.38 4.81e-13 Testicular germ cell tumor; CRC cis rs4148883 0.675 rs34511427 chr4:100105405 G/T cg12011299 chr4:100065546 ADH4 0.5 10.93 0.52 6.36e-24 Alcohol dependence; CRC cis rs11764590 0.813 rs11768212 chr7:1992582 A/C cg23422044 chr7:1970798 MAD1L1 -0.55 -6.93 -0.36 2.19e-11 Neuroticism; CRC cis rs8072100 1.000 rs11870935 chr17:45732605 G/A cg25173405 chr17:45401733 C17orf57 0.46 7.26 0.37 2.88e-12 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs6831352 0.734 rs3100630 chr4:100031715 T/A cg13256891 chr4:100009986 ADH5 0.56 7.89 0.4 4.44e-14 Alcohol dependence; CRC cis rs826838 0.933 rs980573 chr12:39127811 T/C cg13010199 chr12:38710504 ALG10B -0.41 -5.84 -0.31 1.27e-8 Heart rate; CRC cis rs6840360 0.642 rs7678823 chr4:152357119 A/G cg09659197 chr4:152720779 NA 0.34 6.66 0.34 1.14e-10 Intelligence (multi-trait analysis); CRC cis rs4713118 0.869 rs6922574 chr6:27693003 A/T cg15786705 chr6:28176104 NA 0.54 7.35 0.38 1.54e-12 Parkinson's disease; CRC cis rs10504229 0.728 rs17215676 chr8:58152915 G/T cg02725872 chr8:58115012 NA -0.57 -9.07 -0.45 1.09e-17 Developmental language disorder (linguistic errors); CRC cis rs6460942 0.591 rs10262667 chr7:12385391 C/T cg06484146 chr7:12443880 VWDE -0.58 -7.73 -0.39 1.28e-13 Coronary artery disease; CRC cis rs947211 1.000 rs823144 chr1:205744546 C/A cg14893161 chr1:205819251 PM20D1 0.46 6.48 0.34 3.37e-10 Parkinson's disease; CRC cis rs4728302 0.869 rs6963032 chr7:133599527 T/C cg10665199 chr7:133106180 EXOC4 0.38 5.76 0.3 1.96e-8 Intelligence;Intelligence (multi-trait analysis); CRC cis rs9814567 1.000 rs11708531 chr3:134224902 T/C cg06109529 chr3:134205091 CEP63;ANAPC13 -0.81 -12.26 -0.56 1e-28 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs11122272 0.668 rs2790874 chr1:231537988 A/G cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.59 -8.86 -0.44 5.1e-17 Hemoglobin concentration; CRC cis rs10924970 0.649 rs11805093 chr1:235461668 T/C cg09010748 chr1:235293032 TOMM20 -0.43 -5.92 -0.31 8.25e-9 Asthma; CRC trans rs1814175 0.791 rs10769593 chr11:49616217 T/C cg15704280 chr7:45808275 SEPT13 -0.96 -18.09 -0.71 3.02e-51 Height; CRC trans rs703108 0.731 rs7898954 chr10:22323646 A/G cg03128101 chr2:74405376 MOBKL1B -0.51 -5.97 -0.31 6.24e-9 Monocyte percentage of white cells; CRC cis rs9818758 0.607 rs12715434 chr3:49295025 G/C cg07636037 chr3:49044803 WDR6 -0.71 -6.09 -0.32 3.2e-9 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; CRC cis rs7772486 0.790 rs7753696 chr6:146279098 G/T cg23711669 chr6:146136114 FBXO30 -0.72 -12.55 -0.57 8.76e-30 Lobe attachment (rater-scored or self-reported); CRC cis rs7937682 0.889 rs487985 chr11:111517908 G/A cg19812747 chr11:111475976 SIK2 -0.59 -10.07 -0.49 5.54e-21 Primary sclerosing cholangitis; CRC cis rs10979 0.597 rs9496684 chr6:143908687 C/A cg25407410 chr6:143891975 LOC285740 -0.66 -8.82 -0.44 6.76e-17 Hypospadias; CRC cis rs9942416 0.660 rs4704234 chr5:75001432 A/G cg00601450 chr5:74908170 NA 0.38 5.73 0.3 2.32e-8 Age-related disease endophenotypes; CRC cis rs6502050 0.871 rs6502056 chr17:80070912 C/G cg22110888 chr17:80059540 CCDC57 -0.42 -6.54 -0.34 2.39e-10 Life satisfaction; CRC cis rs12594515 0.967 rs71405295 chr15:45988921 T/C cg01629716 chr15:45996671 NA 0.41 8.46 0.42 9.03e-16 Waist circumference;Weight; CRC cis rs55702914 0.712 rs12616329 chr2:198148629 T/C cg10820045 chr2:198174542 NA -0.39 -7.09 -0.36 8.23e-12 Major depression and alcohol dependence; CRC cis rs10256972 0.521 rs10280960 chr7:1103697 A/G cg18402987 chr7:1209562 NA 0.42 6.48 0.34 3.43e-10 Longevity;Endometriosis; CRC cis rs9341808 0.718 rs12203867 chr6:80820833 G/T cg08355045 chr6:80787529 NA 0.43 6.88 0.35 2.95e-11 Sitting height ratio; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg23453622 chr17:79885647 LOC92659;MAFG 0.42 6.14 0.32 2.37e-9 Intelligence (multi-trait analysis); CRC cis rs9937943 0.720 rs112685216 chr16:74609517 G/A cg01733217 chr16:74700730 RFWD3 0.74 8.34 0.42 2.09e-15 Neutrophil percentage of white cells; CRC cis rs2811415 0.597 rs11710595 chr3:127767158 T/C cg13719885 chr3:127795394 NA -0.37 -5.65 -0.3 3.49e-8 Lung function (FEV1/FVC); CRC cis rs6570726 0.791 rs436498 chr6:145876347 G/A cg05347473 chr6:146136440 FBXO30 0.4 6.1 0.32 2.93e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs743757 1.000 rs2298955 chr3:50431194 C/T cg08207895 chr3:50388901 TUSC4;CYB561D2 -0.42 -5.77 -0.3 1.87e-8 Diastolic blood pressure; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg07586819 chr22:38864010 KDELR3 0.47 6.57 0.34 1.95e-10 Anxiety disorder; CRC cis rs6933660 0.745 rs9371517 chr6:151739810 G/T cg14262678 chr6:151773367 RMND1;C6orf211 0.51 8.42 0.42 1.22e-15 Menarche (age at onset); CRC cis rs755249 0.567 rs67886352 chr1:39708703 G/A cg18385671 chr1:39797026 MACF1 -0.44 -6.09 -0.32 3.08e-9 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs10504229 0.683 rs7820302 chr8:58142502 C/T cg24829409 chr8:58192753 C8orf71 -0.51 -7.77 -0.39 9.91e-14 Developmental language disorder (linguistic errors); CRC cis rs6860806 0.531 rs2631359 chr5:131707892 C/T cg09877947 chr5:131593287 PDLIM4 -0.44 -7.15 -0.37 5.51e-12 Breast cancer; CRC cis rs1395 0.744 rs1975384 chr2:27542041 C/T cg14242246 chr2:27434262 C2orf28;SLC5A6 0.35 5.82 0.31 1.42e-8 Blood metabolite levels; CRC cis rs4936891 0.645 rs896891 chr11:123910740 C/T cg22125253 chr11:123886957 OR10G4 0.42 7.8 0.4 8.25e-14 Male fertility; CRC cis rs713587 0.935 rs11676272 chr2:25141538 A/G cg04586622 chr2:25135609 ADCY3 -0.48 -8.67 -0.43 1.96e-16 Body mass index in non-asthmatics; CRC cis rs10464366 0.544 rs953874 chr7:39147916 G/A cg21665744 chr7:39171113 POU6F2 0.41 5.64 0.3 3.71e-8 IgG glycosylation; CRC cis rs514406 0.722 rs7552139 chr1:53387379 G/C cg08859206 chr1:53392774 SCP2 -0.49 -7.67 -0.39 1.96e-13 Monocyte count; CRC cis rs853679 0.517 rs9380047 chr6:28037893 G/T cg21251018 chr6:28226885 NKAPL 0.46 6.12 0.32 2.73e-9 Depression; CRC trans rs11098499 0.865 rs11098513 chr4:120316075 A/G cg25214090 chr10:38739885 LOC399744 0.64 10.0 0.48 1.02e-20 Corneal astigmatism; CRC cis rs7647973 0.925 rs4384984 chr3:49289878 T/G cg07690219 chr3:49449608 TCTA;RHOA -0.49 -5.74 -0.3 2.12e-8 Menarche (age at onset); CRC trans rs7615952 0.866 rs6438949 chr3:125650064 G/C cg02007433 chr3:129722099 NA -0.47 -6.5 -0.34 2.91e-10 Blood pressure (smoking interaction); CRC cis rs807029 0.533 rs722435 chr10:102745062 G/T cg04662943 chr10:102668895 NA 0.61 7.3 0.37 2.2e-12 Ejection fraction in Tripanosoma cruzi seropositivity; CRC cis rs11155671 0.530 rs7764376 chr6:150210344 A/G cg07701084 chr6:150067640 NUP43 0.49 7.2 0.37 4.04e-12 Testicular germ cell tumor; CRC cis rs9905704 0.846 rs11079356 chr17:56864242 C/A cg12560992 chr17:57184187 TRIM37 0.55 7.95 0.4 3.04e-14 Testicular germ cell tumor; CRC trans rs8002861 0.727 rs9525850 chr13:44402100 C/T cg17145862 chr1:211918768 LPGAT1 -0.52 -8.6 -0.43 3.2e-16 Leprosy; CRC cis rs2070488 0.965 rs2284819 chr3:38557161 C/T cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.86 15.8 0.66 3.04e-42 Electrocardiographic conduction measures; CRC cis rs11098699 0.821 rs2047201 chr4:124233384 A/G cg09941581 chr4:124220074 SPATA5 -0.43 -6.35 -0.33 7.09e-10 Mosquito bite size; CRC cis rs1005277 0.579 rs2505198 chr10:38393183 A/C cg00409905 chr10:38381863 ZNF37A -0.66 -11.29 -0.53 3.37e-25 Extrinsic epigenetic age acceleration; CRC cis rs2032447 0.869 rs199752 chr6:26012875 C/T cg03517284 chr6:25882590 NA -0.55 -7.59 -0.39 3.3e-13 Intelligence (multi-trait analysis); CRC cis rs10760158 0.769 rs10760162 chr9:124005183 C/G cg14417974 chr9:124058376 GSN -0.33 -5.63 -0.3 3.95e-8 Pulse pressure; CRC cis rs1949733 1.000 rs2631758 chr4:8495304 G/A cg11789530 chr4:8429930 ACOX3 -0.84 -12.74 -0.57 1.71e-30 Response to antineoplastic agents; CRC cis rs2153535 0.580 rs7743995 chr6:8496212 A/G cg07606381 chr6:8435919 SLC35B3 0.65 10.43 0.5 3.46e-22 Motion sickness; CRC cis rs1003719 0.762 rs3787787 chr21:38463452 T/C cg10648535 chr21:38446584 PIGP;TTC3 0.52 7.41 0.38 1.07e-12 Eye color traits; CRC cis rs853679 0.517 rs9357065 chr6:28129580 T/C cg18032046 chr6:28092343 ZSCAN16 -0.52 -6.01 -0.31 5.02e-9 Depression; CRC cis rs910316 1.000 rs175449 chr14:75590846 A/T cg11812906 chr14:75593930 NEK9 -0.57 -8.96 -0.44 2.49e-17 Height; CRC cis rs7618915 0.547 rs11130317 chr3:52731483 C/T cg08222913 chr3:52553049 STAB1 -0.34 -6.08 -0.32 3.31e-9 Bipolar disorder; CRC cis rs2243480 1.000 rs316325 chr7:65609518 G/A cg18252515 chr7:66147081 NA -1.24 -14.76 -0.63 3.58e-38 Diabetic kidney disease; CRC cis rs9381040 0.610 rs717883 chr6:41045270 T/C cg09580153 chr6:41068724 NFYA;LOC221442 -0.42 -5.94 -0.31 7.32e-9 Alzheimer's disease (late onset); CRC cis rs798554 0.757 rs1182198 chr7:2862906 C/T cg19346786 chr7:2764209 NA -0.43 -7.29 -0.37 2.39e-12 Height; CRC cis rs6754459 0.694 rs4404281 chr2:3706055 C/T cg10645314 chr2:3704589 ALLC -0.45 -6.27 -0.33 1.14e-9 Response to inhaled corticosteroid treatment in asthma (change in FEV1); CRC cis rs6860806 0.507 rs635619 chr5:131720265 G/A cg27615366 chr5:131592974 PDLIM4 -0.32 -5.64 -0.3 3.75e-8 Breast cancer; CRC cis rs9354308 0.840 rs1827157 chr6:66615761 A/G cg07460842 chr6:66804631 NA 0.47 5.96 0.31 6.6e-9 Metabolite levels; CRC cis rs1707322 0.789 rs10789473 chr1:46248131 C/T cg03146154 chr1:46216737 IPP 0.62 8.87 0.44 4.65e-17 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs11679072 1.000 rs11682976 chr2:240445491 A/G cg03276489 chr2:240449683 NA -0.9 -7.54 -0.38 4.55e-13 Blood pressure (smoking interaction); CRC cis rs77633900 0.614 rs280014 chr15:76986890 A/G cg21673338 chr15:77095150 SCAPER -0.75 -7.81 -0.4 7.71e-14 Non-glioblastoma glioma;Glioma; CRC cis rs7584330 0.737 rs7568588 chr2:238364342 G/T cg16989719 chr2:238392110 NA -0.49 -10.2 -0.49 2e-21 Prostate cancer; CRC trans rs3806843 0.900 rs2563280 chr5:140131530 G/C cg06840491 chr10:48416966 GDF2 -0.35 -6.04 -0.32 4.16e-9 Depressive symptoms (multi-trait analysis); CRC cis rs8062405 1.000 rs62037365 chr16:28868962 C/G cg08761264 chr16:28874980 SH2B1 -0.44 -5.91 -0.31 8.33e-9 Cognitive ability (multi-trait analysis);Cognitive ability; CRC cis rs929354 0.772 rs3802117 chr7:156987000 C/T cg16102536 chr7:156981717 UBE3C 0.4 6.77 0.35 5.77e-11 Body mass index; CRC cis rs2991971 0.967 rs12133294 chr1:45988764 C/T cg03123370 chr1:45965343 CCDC163P;MMACHC -0.38 -5.68 -0.3 2.99e-8 High light scatter reticulocyte count; CRC cis rs7618915 0.547 rs2590846 chr3:52692359 C/G cg05573699 chr3:52720067 GNL3;PBRM1 -0.47 -6.69 -0.35 9.78e-11 Bipolar disorder; CRC cis rs2806561 0.577 rs488438 chr1:23498999 T/A cg12483005 chr1:23474871 LUZP1 0.53 7.6 0.39 3.11e-13 Height; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg25199208 chr2:109402912 CCDC138 0.46 6.3 0.33 9.43e-10 Thyroid stimulating hormone; CRC cis rs3750965 0.575 rs3892895 chr11:68884755 A/G cg06818126 chr11:68850279 TPCN2 0.43 6.15 0.32 2.25e-9 Hair color; CRC cis rs8114671 0.562 rs6087649 chr20:33510662 A/G cg07148914 chr20:33460835 GGT7 0.39 6.33 0.33 8.21e-10 Height; CRC cis rs826838 0.935 rs1486357 chr12:39073675 A/G cg26384229 chr12:38710491 ALG10B 0.73 10.2 0.49 2.1e-21 Heart rate; CRC cis rs644799 0.544 rs1254935 chr11:95631470 C/A cg03916912 chr11:95522834 CEP57;FAM76B 0.71 11.83 0.55 3.73e-27 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs12291225 0.585 rs4517475 chr11:14386145 A/G cg19336497 chr11:14380999 RRAS2 -0.52 -9.08 -0.45 1.02e-17 Sense of smell; CRC cis rs2302190 0.882 rs1974586 chr17:56640731 C/T cg12560992 chr17:57184187 TRIM37 0.53 6.15 0.32 2.28e-9 Vitamin D levels; CRC cis rs2692947 0.727 rs749457 chr2:96795944 A/G cg23100626 chr2:96804247 ASTL 0.29 8.17 0.41 6.72e-15 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg15563057 chr5:139493612 PURA 0.48 6.79 0.35 5.29e-11 Response to antipsychotic treatment; CRC cis rs2294693 0.945 rs9369253 chr6:40986538 A/G cg14769373 chr6:40998127 UNC5CL -0.53 -6.76 -0.35 6.38e-11 Gastric cancer;Non-cardia gastric cancer; CRC cis rs10540 1.000 rs61876335 chr11:488878 T/C cg08200582 chr11:442649 ANO9 -0.67 -7.3 -0.37 2.17e-12 Body mass index; CRC trans rs1656966 1.000 rs1656966 chr3:186466252 C/T cg12417590 chr20:42086612 SFRS6 0.38 6.16 0.32 2.1e-9 Myopia (pathological); CRC cis rs11148252 0.716 rs1887360 chr13:52779166 A/G cg02158880 chr13:53174818 NA 0.45 6.29 0.33 1.03e-9 Lewy body disease; CRC cis rs589448 0.900 rs588493 chr12:69751986 G/A cg20891283 chr12:69753455 YEATS4 0.99 21.36 0.76 4.12e-64 Cerebrospinal fluid biomarker levels; CRC cis rs6831352 0.879 rs29001212 chr4:100051877 T/C cg12011299 chr4:100065546 ADH4 -0.49 -9.21 -0.45 4.04e-18 Alcohol dependence; CRC trans rs1814175 0.645 rs10839448 chr11:49938930 G/A cg11707556 chr5:10655725 ANKRD33B -0.51 -9.64 -0.47 1.6e-19 Height; CRC cis rs6988636 0.710 rs59229243 chr8:124155673 G/A cg27053337 chr8:124217698 FAM83A 0.4 5.65 0.3 3.42e-8 Urinary uromodulin levels; CRC cis rs629535 0.814 rs654452 chr8:70074344 C/G cg26132723 chr8:70041827 NA 0.35 5.71 0.3 2.51e-8 Dupuytren's disease; CRC cis rs9902453 0.934 rs34433787 chr17:28496780 T/A cg26525008 chr17:28256777 EFCAB5;SSH2 0.58 9.14 0.45 6.58e-18 Coffee consumption (cups per day); CRC cis rs11758351 1.000 rs80313145 chr6:26194965 T/A cg01420254 chr6:26195488 NA 0.78 7.86 0.4 5.51e-14 Gout;Renal underexcretion gout; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg17906523 chr1:94883536 ABCD3 0.48 6.83 0.35 4.09e-11 Response to antipsychotic treatment; CRC cis rs2011503 1.000 rs77427798 chr19:19652982 T/C cg11584989 chr19:19387371 SF4 0.58 6.43 0.33 4.45e-10 Bipolar disorder; CRC cis rs1223397 0.651 rs2458310 chr6:13310308 G/C cg20827128 chr6:13274284 PHACTR1 0.38 5.8 0.3 1.52e-8 Blood pressure; CRC cis rs853679 0.517 rs35193936 chr6:28076270 A/G cg12273811 chr6:28175739 NA 0.73 9.31 0.46 1.82e-18 Depression; CRC cis rs10489202 0.657 rs3767479 chr1:168069840 C/A cg24449463 chr1:168025552 DCAF6 -0.52 -7.18 -0.37 4.64e-12 Schizophrenia; CRC cis rs7619833 0.506 rs1851366 chr3:27194844 T/C cg02860705 chr3:27208620 NA -0.37 -5.74 -0.3 2.2e-8 Breast cancer; CRC cis rs11628318 0.803 rs10138267 chr14:103035432 C/T cg08075719 chr14:103021372 NA -0.69 -9.47 -0.46 5.8e-19 Platelet count; CRC trans rs12517041 1.000 rs10079487 chr5:23294939 C/T ch.8.1293020R chr8:59333349 UBXN2B -0.55 -6.17 -0.32 2.05e-9 Calcium levels; CRC cis rs72945132 0.882 rs72949076 chr11:70217695 T/C cg14191688 chr11:70257035 CTTN 0.47 6.38 0.33 6.11e-10 Coronary artery disease; CRC cis rs6921919 0.525 rs1361386 chr6:28305604 G/A cg15845792 chr6:28175446 NA 0.49 6.55 0.34 2.19e-10 Autism spectrum disorder or schizophrenia; CRC cis rs12497850 0.897 rs9681717 chr3:48872998 A/G cg07636037 chr3:49044803 WDR6 1.02 17.78 0.7 4.98e-50 Parkinson's disease; CRC cis rs951366 0.789 rs7536483 chr1:205718858 A/T cg24503407 chr1:205819492 PM20D1 0.81 12.46 0.57 1.79e-29 Menarche (age at onset); CRC cis rs6502050 0.835 rs4789677 chr17:80119842 A/G cg19223190 chr17:80058835 NA 0.39 6.23 0.32 1.43e-9 Life satisfaction; CRC cis rs897984 0.647 rs7203999 chr16:31017554 T/C cg02466173 chr16:30829666 NA 0.61 9.24 0.45 3.05e-18 Dementia with Lewy bodies; CRC cis rs11628318 0.803 rs10138267 chr14:103035432 C/T cg23461800 chr14:103021989 NA -0.75 -10.25 -0.49 1.44e-21 Platelet count; CRC cis rs56146971 0.714 rs17804071 chr14:91852876 C/T cg16433844 chr14:91963127 SMEK1 -0.55 -6.54 -0.34 2.36e-10 Alzheimer disease and age of onset; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg11700415 chr19:49140818 SEC1;DBP 0.47 6.49 0.34 3.07e-10 Anxiety disorder; CRC cis rs9807989 0.507 rs1833174 chr2:103034843 T/A cg03938978 chr2:103052716 IL18RAP 0.59 10.13 0.49 3.5e-21 Asthma; CRC cis rs7618915 0.571 rs34115864 chr3:52612178 A/G cg18099408 chr3:52552593 STAB1 -0.45 -7.39 -0.38 1.22e-12 Bipolar disorder; CRC cis rs7804356 1.000 rs4722647 chr7:26890446 G/C cg03456212 chr7:26904342 SKAP2 -0.49 -5.63 -0.3 3.86e-8 Type 1 diabetes; CRC cis rs11190604 1.000 rs2495747 chr10:102328247 C/T cg07080220 chr10:102295463 HIF1AN 0.45 5.71 0.3 2.52e-8 Palmitoleic acid (16:1n-7) levels; CRC cis rs6815814 0.950 rs5743566 chr4:38805942 G/C cg06935464 chr4:38784597 TLR10 0.57 5.97 0.31 6.19e-9 Breast cancer; CRC cis rs6964587 0.869 rs10256780 chr7:91527176 T/A cg17063962 chr7:91808500 NA -0.74 -12.39 -0.56 3.53e-29 Breast cancer; CRC trans rs4873772 0.834 rs4873546 chr8:48576665 T/C cg05343739 chr1:154731938 KCNN3 0.36 6.3 0.33 9.34e-10 Lobe attachment (rater-scored or self-reported); CRC cis rs17376456 0.597 rs1031423 chr5:93276883 A/G cg17533458 chr5:92956826 FAM172A;MIR2277 -0.44 -5.69 -0.3 2.85e-8 Diabetic retinopathy; CRC cis rs939658 0.683 rs8041222 chr15:79465549 A/G cg17916960 chr15:79447300 NA -0.43 -6.5 -0.34 3.06e-10 Refractive error; CRC cis rs3008870 0.583 rs11208985 chr1:67464666 G/A cg08660285 chr1:67390436 MIER1;WDR78 -1.02 -12.41 -0.56 2.97e-29 Lymphocyte percentage of white cells; CRC cis rs10504229 0.724 rs72650827 chr8:58126884 A/T cg04204079 chr8:58130323 NA -0.45 -5.78 -0.3 1.71e-8 Developmental language disorder (linguistic errors); CRC trans rs8002861 0.810 rs9533664 chr13:44440527 T/C cg17145862 chr1:211918768 LPGAT1 0.71 13.99 0.61 3.12e-35 Leprosy; CRC cis rs2842992 0.709 rs1853257 chr6:160212710 C/G cg11366901 chr6:160182831 ACAT2 0.92 13.28 0.59 1.59e-32 Age-related macular degeneration (geographic atrophy); CRC cis rs11190604 1.000 rs2295776 chr10:102295629 G/T cg07080220 chr10:102295463 HIF1AN 0.47 5.66 0.3 3.31e-8 Palmitoleic acid (16:1n-7) levels; CRC cis rs1799949 1.000 rs11653460 chr17:41331306 C/T cg25072359 chr17:41440525 NA 0.43 6.44 0.33 4.32e-10 Menopause (age at onset); CRC cis rs8063761 0.589 rs4238833 chr16:90050689 G/T cg08547343 chr16:90038815 CENPBD1;AFG3L1 0.71 11.34 0.53 2.25e-25 Squamous cell carcinoma; CRC cis rs10504229 0.953 rs57669205 chr8:58172253 T/C cg05313129 chr8:58192883 C8orf71 -0.46 -6.92 -0.36 2.4e-11 Developmental language disorder (linguistic errors); CRC cis rs875971 0.545 rs7787063 chr7:65628999 G/A cg02869306 chr7:64672164 INTS4L1 -0.43 -6.17 -0.32 1.96e-9 Aortic root size; CRC cis rs7811142 0.943 rs3900792 chr7:100004577 C/G cg00814883 chr7:100076585 TSC22D4 -0.72 -9.36 -0.46 1.31e-18 Platelet count; CRC cis rs10751667 0.666 rs4074231 chr11:978219 G/C cg23136738 chr11:925521 AP2A2 -0.42 -7.09 -0.36 8.19e-12 Alzheimer's disease (late onset); CRC cis rs394563 0.726 rs6922130 chr6:149672375 C/G cg11245181 chr6:149772854 ZC3H12D 0.51 9.01 0.44 1.72e-17 Dupuytren's disease; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg13038108 chr4:39461155 LIAS;RPL9 0.44 6.16 0.32 2.16e-9 Response to antipsychotic treatment; CRC cis rs6582630 0.599 rs4882313 chr12:38454011 G/A cg26384229 chr12:38710491 ALG10B -0.54 -7.69 -0.39 1.68e-13 Drug-induced liver injury (flucloxacillin); CRC cis rs2404602 0.684 rs12591622 chr15:76930655 A/T cg23625390 chr15:77176239 SCAPER -0.86 -13.24 -0.59 2.32e-32 Blood metabolite levels; CRC cis rs7666738 0.830 rs28761309 chr4:98867393 C/T cg17366294 chr4:99064904 C4orf37 0.4 6.48 0.34 3.45e-10 Colonoscopy-negative controls vs population controls; CRC cis rs9894429 0.789 rs35887231 chr17:79587126 G/A cg21028142 chr17:79581711 NPLOC4 0.33 6.96 0.36 1.81e-11 Eye color traits; CRC cis rs7618915 0.501 rs12635140 chr3:52738165 C/T cg05573699 chr3:52720067 GNL3;PBRM1 0.49 7.12 0.37 7.01e-12 Bipolar disorder; CRC cis rs9733 0.818 rs12130363 chr1:150688596 T/C cg18016565 chr1:150552671 MCL1 -0.42 -6.26 -0.33 1.18e-9 Tonsillectomy; CRC cis rs3791406 0.654 rs3752804 chr2:240029490 C/T cg14550559 chr2:240039617 HDAC4 -0.48 -6.9 -0.36 2.73e-11 Skin aging (microtopography measurement); CRC cis rs2549003 1.000 rs2549009 chr5:131826765 T/C cg02551604 chr5:131831745 NA 0.59 9.23 0.45 3.38e-18 Asthma (sex interaction); CRC cis rs7617773 0.817 rs11709691 chr3:48303669 A/G cg11946769 chr3:48343235 NME6 0.72 9.65 0.47 1.44e-19 Coronary artery disease; CRC cis rs2033711 0.755 rs4801587 chr19:58936679 C/A cg00825309 chr19:58991885 ZNF446 -0.45 -6.59 -0.34 1.77e-10 Uric acid clearance; CRC cis rs1008375 1.000 rs4698648 chr4:17692715 C/G cg16339924 chr4:17578868 LAP3 0.47 6.31 0.33 8.96e-10 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs9916302 0.904 rs11655531 chr17:37697959 T/C cg00129232 chr17:37814104 STARD3 -0.55 -8.13 -0.41 8.65e-15 Glomerular filtration rate (creatinine); CRC cis rs10170846 1.000 rs10170846 chr2:223517705 C/G cg25565276 chr2:223520875 FARSB -0.67 -9.08 -0.45 1.05e-17 Schizophrenia (inflammation and infection response interaction); CRC cis rs6951245 0.935 rs118132455 chr7:1068232 C/A cg22907277 chr7:1156413 C7orf50 0.71 7.39 0.38 1.26e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs6460942 0.915 rs7809263 chr7:12450589 C/G cg20607287 chr7:12443886 VWDE -0.61 -6.85 -0.35 3.67e-11 Coronary artery disease; CRC cis rs9486719 0.857 rs4839833 chr6:96882069 T/C cg18709589 chr6:96969512 KIAA0776 0.49 6.24 0.33 1.37e-9 Migraine;Coronary artery disease; CRC cis rs6952808 0.929 rs34145223 chr7:1926237 G/A cg00106254 chr7:1943704 MAD1L1 -0.51 -7.71 -0.39 1.55e-13 Bipolar disorder and schizophrenia; CRC cis rs7662987 0.540 rs2851278 chr4:100021253 G/C cg12011299 chr4:100065546 ADH4 0.49 9.26 0.45 2.81e-18 Smoking initiation; CRC cis rs12580194 0.593 rs11171432 chr12:55757696 G/C cg19537932 chr12:55886519 OR6C68 -0.67 -8.83 -0.44 6.47e-17 Cancer; CRC cis rs4862750 0.872 rs56389997 chr4:187894796 A/C cg03452623 chr4:187889614 NA -0.93 -22.17 -0.77 3.01e-67 Lobe attachment (rater-scored or self-reported); CRC cis rs1059312 0.545 rs7312683 chr12:129280105 T/C cg09035930 chr12:129282057 SLC15A4 0.45 6.85 0.35 3.58e-11 Systemic lupus erythematosus; CRC cis rs8044868 0.530 rs4788464 chr16:72223899 T/C cg23815491 chr16:72088622 HP 0.43 6.38 0.33 6.14e-10 Body mass index (change over time) in cancer or chronic obstructive pulmonary disease;Body mass index (change over time) in cancer; CRC cis rs9649213 0.593 rs62478177 chr7:97964611 G/A cg21770322 chr7:97807741 LMTK2 0.51 8.33 0.42 2.25e-15 Prostate cancer (SNP x SNP interaction); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg24596729 chr1:165345813 NA 0.39 6.92 0.36 2.32e-11 Liver disease severity in Alagille syndrome; CRC cis rs926938 0.618 rs360617 chr1:115404099 G/A cg12756093 chr1:115239321 AMPD1 0.52 7.87 0.4 5.1e-14 Autism; CRC cis rs9322193 0.923 rs4870529 chr6:150037572 A/G cg13206674 chr6:150067644 NUP43 0.65 9.75 0.47 6.68e-20 Lung cancer; CRC cis rs10751667 0.666 rs10902239 chr11:946484 A/G cg01483505 chr11:975446 AP2A2 -0.43 -7.18 -0.37 4.75e-12 Alzheimer's disease (late onset); CRC cis rs9470366 0.848 rs66761782 chr6:36636080 T/C cg08179530 chr6:36648295 CDKN1A 0.55 6.6 0.34 1.66e-10 QRS duration; CRC cis rs6582630 0.555 rs2197308 chr12:38281261 A/G cg13010199 chr12:38710504 ALG10B -0.4 -5.68 -0.3 2.95e-8 Drug-induced liver injury (flucloxacillin); CRC cis rs7640424 0.826 rs7635063 chr3:107818777 C/T cg09227934 chr3:107805635 CD47 -0.49 -7.62 -0.39 2.68e-13 Body mass index; CRC cis rs7772486 0.701 rs7772717 chr6:145954854 T/C cg05347473 chr6:146136440 FBXO30 0.4 6.04 0.32 4.05e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs61160187 0.610 rs4700397 chr5:60135962 A/G cg16298547 chr5:60138761 ELOVL7 0.29 6.13 0.32 2.58e-9 Educational attainment (years of education);Educational attainment (college completion); CRC cis rs950169 0.580 rs11635597 chr15:85165699 C/T cg17507749 chr15:85114479 UBE2QP1 0.64 9.13 0.45 7.19e-18 Schizophrenia; CRC cis rs9309711 0.544 rs9309712 chr2:3491327 G/T cg15541040 chr2:3486749 NA -0.51 -8.21 -0.41 5.03e-15 Neurofibrillary tangles; CRC cis rs13108904 0.517 rs13134568 chr4:1334289 G/A cg15763984 chr4:1342303 KIAA1530 0.44 6.84 0.35 3.99e-11 Obesity-related traits; CRC cis rs7666738 0.830 rs7691433 chr4:98968118 A/T cg17366294 chr4:99064904 C4orf37 0.41 6.77 0.35 5.79e-11 Colonoscopy-negative controls vs population controls; CRC cis rs9814567 0.896 rs7653807 chr3:134345724 T/C cg06109529 chr3:134205091 CEP63;ANAPC13 -0.67 -9.57 -0.47 2.7e-19 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs2243480 0.803 rs13224048 chr7:65993766 G/A cg25985355 chr7:65971099 NA -0.52 -5.94 -0.31 7.09e-9 Diabetic kidney disease; CRC cis rs728616 0.867 rs118134654 chr10:81744381 G/A cg05935833 chr10:81318306 SFTPA2 -0.76 -8.27 -0.41 3.4e-15 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs801193 1.000 rs3857688 chr7:66127806 G/A cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.44 -6.46 -0.34 3.75e-10 Aortic root size; CRC cis rs79057730 0.599 rs6944167 chr7:826274 G/C cg06242242 chr7:766104 PRKAR1B;HEATR2 0.55 5.83 0.31 1.32e-8 Initial pursuit acceleration; CRC cis rs7666738 0.830 rs3896704 chr4:99034252 C/T cg17366294 chr4:99064904 C4orf37 0.44 7.48 0.38 6.96e-13 Colonoscopy-negative controls vs population controls; CRC cis rs35146811 0.735 rs2272345 chr7:99797031 C/G cg13334819 chr7:99746414 C7orf59 -0.53 -6.92 -0.36 2.33e-11 Coronary artery disease; CRC trans rs6951245 1.000 rs79327308 chr7:1108141 A/C cg13565492 chr6:43139072 SRF -0.72 -7.5 -0.38 6.06e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs7666738 0.830 rs890470 chr4:98923435 A/C cg17366294 chr4:99064904 C4orf37 0.43 7.32 0.37 1.95e-12 Colonoscopy-negative controls vs population controls; CRC cis rs11628318 0.802 rs6575926 chr14:103050183 G/A cg23461800 chr14:103021989 NA -0.75 -9.92 -0.48 1.9e-20 Platelet count; CRC cis rs2354432 0.556 rs4295925 chr1:146857335 T/C cg25205988 chr1:146714368 CHD1L 1.16 10.16 0.49 2.94e-21 Mitochondrial DNA levels; CRC cis rs6500395 0.926 rs1120275 chr16:48598737 T/G cg04672837 chr16:48644449 N4BP1 0.42 5.99 0.31 5.43e-9 Response to tocilizumab in rheumatoid arthritis; CRC cis rs7072216 0.770 rs1737 chr10:100176366 T/C cg26618903 chr10:100175079 PYROXD2 -0.43 -7.31 -0.37 2.06e-12 Metabolite levels; CRC cis rs4555082 0.957 rs2816622 chr14:105733114 T/C cg10792982 chr14:105748885 BRF1 0.36 6.17 0.32 2.04e-9 Mean platelet volume;Platelet distribution width; CRC cis rs1799949 0.526 rs4352088 chr17:41414679 A/G cg19454999 chr17:41278357 BRCA1;NBR2 0.53 8.06 0.41 1.38e-14 Menopause (age at onset); CRC cis rs57221529 0.766 rs12519763 chr5:559145 C/T cg14541582 chr5:601475 NA -0.33 -6.6 -0.34 1.61e-10 Lung disease severity in cystic fibrosis; CRC cis rs2302190 0.769 rs7218778 chr17:56664248 T/G cg25885038 chr17:56607967 SEPT4 -0.51 -7.7 -0.39 1.63e-13 Vitamin D levels; CRC cis rs4665809 0.652 rs2241739 chr2:26411894 C/T cg08067268 chr2:26466485 HADHB;HADHA -0.64 -8.48 -0.42 7.63e-16 Gut microbiome composition (summer); CRC cis rs477895 0.653 rs11602181 chr11:63896591 C/G cg19465662 chr11:63993652 NUDT22;TRPT1 0.73 9.13 0.45 7.28e-18 Mean platelet volume; CRC cis rs8060686 0.641 rs55725810 chr16:68189636 C/T cg26727032 chr16:67993705 SLC12A4 -0.53 -6.19 -0.32 1.84e-9 HDL cholesterol;Metabolic syndrome; CRC cis rs73206853 0.841 rs7963504 chr12:110906880 C/A cg12870014 chr12:110450643 ANKRD13A 0.81 8.45 0.42 9.43e-16 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC cis rs7894051 1.000 rs7070635 chr10:135190127 T/C cg20534287 chr10:135191450 PAOX -0.68 -6.72 -0.35 8.04e-11 Lifespan; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg09326880 chr3:43147587 C3orf39 0.38 5.97 0.31 6.14e-9 Liver disease severity in Alagille syndrome; CRC cis rs2153535 0.542 rs6905925 chr6:8440030 C/T cg07606381 chr6:8435919 SLC35B3 0.68 10.86 0.51 1.08e-23 Motion sickness; CRC trans rs208520 0.661 rs7766144 chr6:66827795 C/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.08 -14.89 -0.63 1.12e-38 Exhaled nitric oxide output; CRC cis rs28386778 0.901 rs2665855 chr17:61965143 A/G cg00280220 chr17:61926910 NA 0.35 5.74 0.3 2.18e-8 Prudent dietary pattern; CRC cis rs1838105 0.674 rs2873131 chr17:45166056 T/C cg16759221 chr17:45003025 GOSR2 -0.62 -9.49 -0.46 5.03e-19 Nonsyndromic cleft lip with cleft palate; CRC cis rs75920871 0.528 rs12279066 chr11:116913909 C/G cg20608306 chr11:116969690 SIK3 -0.33 -6.33 -0.33 7.93e-10 Subjective well-being; CRC trans rs1814175 0.684 rs1827015 chr11:49585241 A/G cg15704280 chr7:45808275 SEPT13 -0.83 -13.56 -0.6 1.44e-33 Height; CRC cis rs881375 0.967 rs1930780 chr9:123686219 C/G cg09586646 chr9:123605570 PSMD5;LOC253039 0.5 6.75 0.35 6.64e-11 Rheumatoid arthritis; CRC cis rs853679 0.517 rs9393897 chr6:28127710 G/T cg12963246 chr6:28129442 ZNF389 0.49 5.7 0.3 2.71e-8 Depression; CRC cis rs9682041 1.000 rs6444920 chr3:170090374 A/G cg11886554 chr3:170076028 SKIL 0.84 9.04 0.45 1.41e-17 Glomerular filtration rate in non diabetics (creatinine);Glomerular filtration rate (creatinine); CRC cis rs67478160 0.679 rs7156834 chr14:104211180 G/A cg08213375 chr14:104286397 PPP1R13B 0.67 14.1 0.61 1.21e-35 Schizophrenia; CRC cis rs9549328 0.700 rs3011474 chr13:113617865 T/C cg20742385 chr13:113633654 MCF2L 0.55 9.36 0.46 1.33e-18 Systolic blood pressure; CRC cis rs10504229 0.679 rs2317991 chr8:58035080 C/T cg22535103 chr8:58192502 C8orf71 0.43 5.93 0.31 7.85e-9 Developmental language disorder (linguistic errors); CRC cis rs4713118 0.515 rs9368549 chr6:28050047 T/A cg12172441 chr6:28176163 NA 0.6 7.27 0.37 2.64e-12 Parkinson's disease; CRC cis rs4927850 1.000 rs10881564 chr3:195750326 C/T cg12923728 chr3:195709715 SDHAP1 -0.7 -10.87 -0.51 1.05e-23 Pancreatic cancer; CRC cis rs3092073 0.624 rs34293711 chr20:44587186 C/T cg27529037 chr20:44575021 PCIF1 0.4 7.01 0.36 1.38e-11 Intelligence (multi-trait analysis); CRC cis rs9928842 0.824 rs12924999 chr16:75262425 T/G cg09066997 chr16:75300724 BCAR1 0.68 6.36 0.33 6.83e-10 Alcoholic chronic pancreatitis; CRC cis rs720844 0.748 rs12464036 chr2:149371609 A/G cg09247360 chr2:149335327 NA -0.54 -5.75 -0.3 2.07e-8 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs727505 0.607 rs67454509 chr7:124792500 A/G cg23710748 chr7:124431027 NA -0.64 -10.26 -0.49 1.34e-21 Lewy body disease; CRC cis rs7618915 0.547 rs12496476 chr3:52708737 A/G cg08222913 chr3:52553049 STAB1 -0.34 -6.12 -0.32 2.7e-9 Bipolar disorder; CRC trans rs459571 0.916 rs467303 chr9:136904835 C/T cg15028160 chr19:49622717 PPFIA3;C19orf73 -0.55 -6.79 -0.35 5.26e-11 Platelet distribution width; CRC cis rs6964587 1.000 rs12533199 chr7:91757393 C/T cg17063962 chr7:91808500 NA 0.84 14.73 0.63 4.6e-38 Breast cancer; CRC cis rs4819052 0.851 rs4819040 chr21:46659762 T/C cg11663144 chr21:46675770 NA -0.64 -10.45 -0.5 2.87e-22 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs9858542 0.953 rs3811697 chr3:49590770 C/T cg00383909 chr3:49044727 WDR6 0.44 5.64 0.3 3.76e-8 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs514406 0.708 rs514881 chr1:53336737 A/G cg08859206 chr1:53392774 SCP2 0.58 9.4 0.46 9.52e-19 Monocyte count; CRC cis rs11971779 0.680 rs10085902 chr7:139109105 G/C cg07862535 chr7:139043722 LUC7L2 0.57 7.32 0.37 1.92e-12 Diisocyanate-induced asthma; CRC cis rs6502050 0.871 rs11870632 chr17:80075406 T/C cg13198984 chr17:80129470 CCDC57 -0.48 -8.57 -0.43 4.01e-16 Life satisfaction; CRC cis rs1799949 0.930 rs4445938 chr17:41337900 A/C cg19454999 chr17:41278357 BRCA1;NBR2 0.55 8.64 0.43 2.47e-16 Menopause (age at onset); CRC cis rs853679 1.000 rs735765 chr6:28170297 G/A cg12273811 chr6:28175739 NA 0.64 6.34 0.33 7.38e-10 Depression; CRC cis rs13108904 0.557 rs1250086 chr4:1248051 G/A cg20092199 chr4:1342459 KIAA1530 -0.38 -6.03 -0.32 4.51e-9 Obesity-related traits; CRC cis rs2075371 1.000 rs2241334 chr7:133979225 C/G cg02659138 chr7:134003124 SLC35B4 0.35 6.03 0.32 4.31e-9 Mean platelet volume; CRC cis rs8067545 0.532 rs56371654 chr17:19960362 G/T cg13482628 chr17:19912719 NA 0.41 5.71 0.3 2.5e-8 Schizophrenia; CRC cis rs6456156 0.586 rs9459862 chr6:167487011 A/G cg07741184 chr6:167504864 NA -0.33 -5.79 -0.3 1.63e-8 Primary biliary cholangitis; CRC cis rs3785574 0.962 rs2727329 chr17:61924566 C/T cg25654072 chr17:61904446 PSMC5;FTSJ3 0.44 6.02 0.31 4.71e-9 Height; CRC cis rs7296418 0.961 rs7957096 chr12:123544878 A/G cg05973401 chr12:123451056 ABCB9 0.43 6.0 0.31 5.13e-9 Platelet count; CRC cis rs4727963 0.755 rs6943941 chr7:122705651 G/A cg03640110 chr7:122635026 TAS2R16 -0.33 -6.02 -0.31 4.77e-9 Adverse response to chemotherapy (neutropenia/leucopenia) (docetaxel); CRC trans rs57221529 0.766 rs1399381 chr5:589853 G/T cg25482853 chr8:67687455 SGK3 1.24 14.83 0.63 1.93e-38 Lung disease severity in cystic fibrosis; CRC trans rs6703335 0.870 rs10803142 chr1:243598234 A/G cg00050312 chr17:64299065 PRKCA 0.42 5.96 0.31 6.49e-9 Schizophrenia;Schizophrenia, schizoaffective disorder or bipolar disorder; CRC cis rs1949733 1.000 rs1880023 chr4:8480831 C/T cg13073564 chr4:8508604 NA 0.5 7.73 0.39 1.34e-13 Response to antineoplastic agents; CRC trans rs951252 0.504 rs11734405 chr4:146081096 C/T cg04607442 chr13:21872219 NA 0.48 6.35 0.33 7.19e-10 Hip circumference; CRC trans rs10242455 0.702 rs3528 chr7:99055940 T/C cg09045935 chr12:6379348 NA 1.02 8.82 0.44 6.84e-17 Blood metabolite levels; CRC cis rs9378357 0.850 rs9392473 chr6:3291236 C/T cg08754725 chr6:3293098 SLC22A23 -0.8 -7.45 -0.38 8.28e-13 Obesity-related traits; CRC cis rs1448094 0.511 rs10746353 chr12:86150146 A/T cg00310523 chr12:86230176 RASSF9 -0.36 -5.92 -0.31 8.25e-9 Major depressive disorder; CRC cis rs7493 1.000 rs7786401 chr7:95034001 G/T cg21856205 chr7:94953877 PON1 -0.52 -6.69 -0.35 9.73e-11 Yu-Zhi constitution type in type 2 diabetes; CRC trans rs9929218 1.000 rs12921546 chr16:68780069 G/A cg04657470 chr2:198365150 HSPE1;HSPD1 -0.95 -14.09 -0.61 1.3e-35 Colorectal cancer; CRC cis rs853679 0.599 rs188015 chr6:27877446 T/A cg03623178 chr6:28175578 NA 0.85 7.85 0.4 5.92e-14 Depression; CRC cis rs6500395 1.000 rs12933948 chr16:48705825 C/G cg04672837 chr16:48644449 N4BP1 -0.44 -6.31 -0.33 9.05e-10 Response to tocilizumab in rheumatoid arthritis; CRC cis rs763121 0.853 rs9610986 chr22:39025277 T/C cg06022373 chr22:39101656 GTPBP1 0.76 12.1 0.55 4.03e-28 Menopause (age at onset); CRC cis rs40363 1.000 rs1635393 chr16:3520493 C/T cg22508957 chr16:3507546 NAT15 0.89 11.19 0.52 7.79e-25 Tuberculosis; CRC cis rs4731207 0.596 rs7792654 chr7:124653637 A/G cg23710748 chr7:124431027 NA -0.39 -6.25 -0.33 1.24e-9 Cutaneous malignant melanoma; CRC cis rs56235845 0.694 rs6860069 chr5:176755841 C/T cg16006841 chr5:176797999 RGS14 0.56 9.19 0.45 4.66e-18 Hemoglobin concentration;Hematocrit; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg14086160 chr1:159895389 TAGLN2 0.4 6.62 0.34 1.48e-10 Liver disease severity in Alagille syndrome; CRC trans rs4942242 1.000 rs4942242 chr13:44217064 A/G cg19169023 chr15:41853346 TYRO3 0.52 7.78 0.39 9.18e-14 Response to tocilizumab in rheumatoid arthritis; CRC cis rs73198271 0.562 rs75525911 chr8:8659359 C/A cg01851573 chr8:8652454 MFHAS1 0.5 6.07 0.32 3.6e-9 Bone ultrasound measurement (broadband ultrasound attenuation); CRC cis rs6141769 0.542 rs28523897 chr20:31301248 C/T cg13636640 chr20:31349939 DNMT3B -0.39 -5.84 -0.31 1.27e-8 Subjective well-being; CRC cis rs9611565 0.765 rs132915 chr22:41805782 T/C cg06634786 chr22:41940651 POLR3H 0.62 7.19 0.37 4.42e-12 Vitiligo; CRC cis rs908922 0.887 rs7535188 chr1:152475899 G/A cg23254163 chr1:152506842 NA 0.45 8.29 0.42 2.9e-15 Hair morphology; CRC cis rs4494114 0.967 rs9438978 chr1:39355058 G/T cg25970120 chr1:39325951 RRAGC -0.42 -5.73 -0.3 2.25e-8 Blood protein levels; CRC trans rs1908814 0.516 rs60176945 chr8:11796674 T/C cg08975724 chr8:8085496 FLJ10661 0.4 6.0 0.31 5.24e-9 Neuroticism; CRC cis rs17376456 0.877 rs7701974 chr5:93311417 C/T cg25358565 chr5:93447407 FAM172A 1.06 10.59 0.5 9.22e-23 Diabetic retinopathy; CRC cis rs727479 0.502 rs3825800 chr15:51506663 A/C cg19946085 chr15:51559439 CYP19A1 -0.3 -6.08 -0.32 3.36e-9 Estradiol levels; CRC cis rs4727027 0.704 rs12537763 chr7:148903984 G/A cg23583168 chr7:148888333 NA -0.93 -17.91 -0.7 1.51e-50 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC cis rs7618915 0.547 rs62253700 chr3:52625019 T/A cg05573699 chr3:52720067 GNL3;PBRM1 -0.46 -6.57 -0.34 2.01e-10 Bipolar disorder; CRC cis rs59104589 0.521 rs2240482 chr2:242405021 C/T cg19488206 chr2:242435732 STK25 0.48 7.71 0.39 1.5e-13 Fibrinogen levels; CRC cis rs2013441 0.613 rs4925082 chr17:19994673 C/T cg13482628 chr17:19912719 NA -0.35 -5.62 -0.3 3.97e-8 Obesity-related traits; CRC cis rs1552244 0.554 rs13081079 chr3:10056348 A/G cg16606324 chr3:10149918 C3orf24 0.47 6.91 0.36 2.5e-11 Alzheimer's disease; CRC cis rs9549367 0.713 rs3024764 chr13:113824314 A/G cg24300038 chr13:113819356 PROZ -0.47 -6.06 -0.32 3.75e-9 Platelet distribution width; CRC cis rs10782582 0.545 rs12138018 chr1:76186794 T/C cg03433033 chr1:76189801 ACADM -0.44 -6.55 -0.34 2.24e-10 Daytime sleep phenotypes; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg08023809 chr12:53645616 MFSD5 0.45 6.39 0.33 5.55e-10 Response to antipsychotic treatment; CRC cis rs13191362 1.000 rs13191362 chr6:163033350 A/G cg23758597 chr6:163146217 PARK2 -0.64 -6.5 -0.34 2.98e-10 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs6952808 1.000 rs12699404 chr7:1894022 A/T cg20295408 chr7:1910781 MAD1L1 -0.45 -6.06 -0.32 3.72e-9 Bipolar disorder and schizophrenia; CRC cis rs2243480 1.000 rs906134 chr7:65444288 G/C cg18252515 chr7:66147081 NA -1.08 -12.36 -0.56 4.53e-29 Diabetic kidney disease; CRC cis rs1862618 0.802 rs4389648 chr5:56103602 A/G cg24531977 chr5:56204891 C5orf35 -0.84 -11.22 -0.53 5.99e-25 Initial pursuit acceleration; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg05935374 chr11:82782929 RAB30 0.43 6.16 0.32 2.09e-9 Response to antipsychotic treatment; CRC cis rs514406 0.929 rs557847 chr1:53333116 A/G cg08859206 chr1:53392774 SCP2 -0.43 -6.81 -0.35 4.75e-11 Monocyte count; CRC trans rs783540 0.843 rs28374463 chr15:83299364 A/C cg18393722 chr15:85113863 UBE2QP1 -0.37 -6.22 -0.32 1.54e-9 Schizophrenia; CRC cis rs2115630 0.645 rs2292463 chr15:85175750 A/G cg11189052 chr15:85197271 WDR73 -0.66 -11.1 -0.52 1.57e-24 P wave terminal force; CRC cis rs10493773 0.609 rs10873716 chr1:86178347 G/T cg17807903 chr1:86174739 ZNHIT6 -0.64 -17.41 -0.69 1.47e-48 Urate levels in overweight individuals; CRC cis rs965469 0.779 rs6051770 chr20:3327014 A/G cg25506879 chr20:3388711 C20orf194 -0.37 -5.76 -0.3 1.91e-8 IFN-related cytopenia; CRC cis rs909002 0.811 rs11575883 chr1:32085485 G/A cg13919466 chr1:32135498 COL16A1 -0.32 -6.04 -0.32 4.19e-9 Intelligence (multi-trait analysis); CRC cis rs17152411 1.000 rs61873277 chr10:126619331 C/A cg07906193 chr10:126599966 NA 0.6 6.47 0.34 3.59e-10 Height; CRC cis rs4908768 0.501 rs11121186 chr1:8540341 G/A cg20416874 chr1:8611966 RERE -0.4 -5.65 -0.3 3.41e-8 Neuroticism (multi-trait analysis);Subjective well-being (multi-trait analysis); CRC cis rs1577917 1.000 rs12212733 chr6:86726013 A/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.53 -6.64 -0.34 1.32e-10 Response to antipsychotic treatment; CRC cis rs7615952 0.641 rs12491577 chr3:125731131 C/T cg18479299 chr3:125709523 NA -0.54 -6.43 -0.33 4.52e-10 Blood pressure (smoking interaction); CRC cis rs7208859 0.573 rs216442 chr17:28931197 T/G cg13385521 chr17:29058706 SUZ12P 0.58 6.35 0.33 7.04e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs10946940 0.965 rs10946935 chr6:27501345 T/C cg08798685 chr6:27730294 NA 0.38 5.72 0.3 2.38e-8 Systemic lupus erythematosus; CRC cis rs1555322 0.530 rs7004 chr20:33866753 G/C cg03689076 chr20:33865952 NA 0.57 7.6 0.39 3.12e-13 Attention deficit hyperactivity disorder; CRC cis rs17376456 0.877 rs34184666 chr5:93444584 T/C cg21475434 chr5:93447410 FAM172A 0.74 7.63 0.39 2.64e-13 Diabetic retinopathy; CRC cis rs6500395 0.928 rs7199206 chr16:48702538 A/G cg04672837 chr16:48644449 N4BP1 -0.44 -6.36 -0.33 6.91e-10 Response to tocilizumab in rheumatoid arthritis; CRC cis rs9911578 0.967 rs1267542 chr17:56654690 T/C cg12560992 chr17:57184187 TRIM37 -0.91 -16.78 -0.68 4.41e-46 Intelligence (multi-trait analysis); CRC cis rs3996993 0.809 rs4147615 chr6:52657321 A/G cg20803780 chr6:52668592 GSTA1 0.36 6.5 0.34 2.93e-10 Hemoglobin concentration; CRC cis rs951366 0.873 rs823118 chr1:205723572 C/T cg14893161 chr1:205819251 PM20D1 0.48 7.29 0.37 2.3e-12 Menarche (age at onset); CRC cis rs10504229 1.000 rs17216620 chr8:58169412 A/G cg24829409 chr8:58192753 C8orf71 -0.67 -11.22 -0.53 5.96e-25 Developmental language disorder (linguistic errors); CRC cis rs9916302 0.605 rs12938099 chr17:37612910 T/G cg00129232 chr17:37814104 STARD3 -0.58 -7.16 -0.37 5.25e-12 Glomerular filtration rate (creatinine); CRC cis rs951366 0.646 rs1772159 chr1:205759195 G/A cg26354017 chr1:205819088 PM20D1 0.89 14.18 0.62 5.79e-36 Menarche (age at onset); CRC cis rs9326248 0.954 rs521171 chr11:117064693 C/G cg20608306 chr11:116969690 SIK3 0.29 5.7 0.3 2.67e-8 Blood protein levels; CRC cis rs12188164 0.686 rs72711370 chr5:421057 A/C cg21972741 chr5:435613 AHRR 0.5 6.74 0.35 6.96e-11 Cystic fibrosis severity; CRC trans rs6981523 0.553 rs11989369 chr8:11055385 A/G cg06636001 chr8:8085503 FLJ10661 0.53 7.68 0.39 1.79e-13 Neuroticism; CRC cis rs4713118 0.523 rs2179096 chr6:27665920 C/T cg21251018 chr6:28226885 NKAPL 0.38 5.96 0.31 6.42e-9 Parkinson's disease; CRC cis rs3785574 0.962 rs2584632 chr17:61880641 G/A cg22520471 chr17:61851767 DDX42;CCDC47 0.47 6.52 0.34 2.63e-10 Height; CRC cis rs13412757 0.646 rs346829 chr2:8457927 G/C cg12167548 chr2:8464763 NA 0.35 6.59 0.34 1.79e-10 Asthma;Itch intensity from mosquito bite adjusted by bite size; CRC cis rs4253772 0.550 rs9615949 chr22:46722531 C/T cg24881330 chr22:46731750 TRMU 0.63 6.12 0.32 2.59e-9 LDL cholesterol;Cholesterol, total; CRC cis rs17270561 0.609 rs9358872 chr6:25727517 G/A cg16482183 chr6:26056742 HIST1H1C 0.83 10.59 0.5 9.49e-23 Iron status biomarkers; CRC cis rs5753618 0.583 rs2899164 chr22:31790289 G/A cg22777020 chr22:31556080 RNF185 0.52 6.23 0.33 1.39e-9 Colorectal cancer; CRC cis rs3106136 0.967 rs2171381 chr4:95224768 T/A cg11021082 chr4:95130006 SMARCAD1 -0.46 -7.01 -0.36 1.32e-11 Capecitabine sensitivity; CRC cis rs3820068 0.581 rs6692489 chr1:15928517 A/G cg27534772 chr1:16042836 PLEKHM2 0.55 10.92 0.52 6.82e-24 Systolic blood pressure; CRC cis rs9300255 0.602 rs1569068 chr12:123632276 A/G cg00376283 chr12:123451042 ABCB9 -0.5 -6.5 -0.34 2.94e-10 Neutrophil percentage of white cells; CRC cis rs79349575 0.783 rs55771415 chr17:46999937 C/T cg00947319 chr17:47005597 UBE2Z -0.34 -5.87 -0.31 1.06e-8 Type 2 diabetes; CRC trans rs57590327 0.503 rs9874184 chr3:81505439 C/T cg23387109 chr10:94051229 MARCH5;CPEB3 -0.44 -6.0 -0.31 5.25e-9 Extraversion; CRC cis rs79057730 0.528 rs4719313 chr7:822501 C/T cg05729249 chr7:766119 PRKAR1B;HEATR2 0.69 7.28 0.37 2.49e-12 Initial pursuit acceleration; CRC cis rs2032447 0.714 rs199725 chr6:25953684 A/G cg12588279 chr6:26043732 HIST1H2BB 0.41 5.97 0.31 6.05e-9 Intelligence (multi-trait analysis); CRC cis rs17270561 0.583 rs6908407 chr6:25703656 A/T cg17691542 chr6:26056736 HIST1H1C -0.63 -8.01 -0.4 1.98e-14 Iron status biomarkers; CRC cis rs2228479 0.702 rs17233176 chr16:89832751 G/C cg06656553 chr16:89960601 TCF25 -0.7 -5.83 -0.31 1.34e-8 Skin colour saturation; CRC cis rs9914988 0.832 rs35033748 chr17:27179590 T/C cg19196414 chr17:27188595 MIR451;MIR144 0.39 5.6 0.3 4.51e-8 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs11105298 0.838 rs10858862 chr12:89842053 T/C cg00757033 chr12:89920650 WDR51B 0.37 6.15 0.32 2.24e-9 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; CRC cis rs6674970 1.000 rs6656450 chr1:151089602 A/T cg11822372 chr1:151115635 SEMA6C 0.53 7.59 0.39 3.23e-13 Childhood ear infection; CRC cis rs8180040 0.932 rs1038394 chr3:47464122 A/G cg27129171 chr3:47204927 SETD2 0.51 7.98 0.4 2.54e-14 Colorectal cancer; CRC cis rs9611565 0.765 rs767593 chr22:41779971 G/T cg03806693 chr22:41940476 POLR3H -1.07 -13.4 -0.59 5.86e-33 Vitiligo; CRC cis rs2576037 0.526 rs4890707 chr18:44497724 C/G cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.64 -10.17 -0.49 2.68e-21 Personality dimensions; CRC cis rs1552244 0.882 rs113268531 chr3:10167069 A/G cg10729496 chr3:10149963 C3orf24 0.5 6.49 0.34 3.18e-10 Alzheimer's disease; CRC cis rs2019137 0.936 rs731834 chr2:113957198 A/C cg21482265 chr2:113992762 PAX8;LOC440839;LOC654433 -0.46 -6.58 -0.34 1.87e-10 Lymphocyte counts; CRC cis rs2084898 0.506 rs488672 chr11:120047745 A/G cg16005559 chr11:120040616 NA 0.5 7.32 0.37 1.96e-12 Stroke (pediatric); CRC trans rs6956675 0.915 rs6965334 chr7:62645446 A/G cg01314568 chr7:57830625 NA -0.6 -8.32 -0.42 2.43e-15 Obesity-related traits; CRC cis rs7677751 0.806 rs61320297 chr4:55088175 G/A cg17187183 chr4:55093834 PDGFRA 0.52 7.41 0.38 1.07e-12 Corneal astigmatism; CRC trans rs2235573 0.657 rs5756890 chr22:38445400 C/A cg19894588 chr14:64061835 NA 0.42 6.04 0.32 4.26e-9 Glioblastoma;Glioma; CRC cis rs1059312 0.808 rs4482069 chr12:129294252 G/C cg21616243 chr12:129299702 MGC16384;SLC15A4 -0.74 -12.86 -0.58 5.84e-31 Systemic lupus erythematosus; CRC cis rs9467773 1.000 rs9393731 chr6:26529374 C/T cg09904177 chr6:26538194 HMGN4 0.86 14.9 0.63 9.92e-39 Intelligence (multi-trait analysis); CRC cis rs637571 0.522 rs542332 chr11:65744421 C/T cg17985854 chr11:65770987 BANF1;EIF1AD 0.52 8.77 0.44 9.91e-17 Eosinophil percentage of white cells; CRC cis rs9902453 0.716 rs3098949 chr17:27978694 C/T cg26525008 chr17:28256777 EFCAB5;SSH2 0.74 12.63 0.57 4.52e-30 Coffee consumption (cups per day); CRC cis rs1475911 1.000 rs55645900 chr21:43515728 G/T cg24372256 chr21:43528868 UMODL1;C21orf128 -0.58 -7.52 -0.38 5.11e-13 IgG glycosylation; CRC trans rs61931739 0.517 rs7313663 chr12:34417058 T/C cg13010199 chr12:38710504 ALG10B 0.44 6.32 0.33 8.5e-10 Morning vs. evening chronotype; CRC cis rs2404602 0.692 rs58889902 chr15:77173070 A/C cg03037974 chr15:76606532 NA 0.68 11.55 0.54 4.06e-26 Blood metabolite levels; CRC cis rs870825 0.616 rs28563856 chr4:185635581 G/A cg04058563 chr4:185651563 MLF1IP 0.73 9.38 0.46 1.13e-18 Blood protein levels; CRC cis rs372883 0.613 rs1153289 chr21:30686212 G/T cg24692254 chr21:30365293 RNF160 -0.59 -8.95 -0.44 2.68e-17 Pancreatic cancer; CRC cis rs67340775 0.541 rs169287 chr6:27854760 C/A cg19041857 chr6:27730383 NA -0.63 -6.9 -0.36 2.72e-11 Lung cancer in ever smokers; CRC cis rs6604026 0.656 rs12074608 chr1:93411781 T/C cg17283838 chr1:93427260 FAM69A 0.42 5.61 0.3 4.24e-8 Multiple sclerosis; CRC cis rs1401999 0.510 rs2293001 chr3:183700211 C/T cg01324343 chr3:183735012 ABCC5 0.59 9.36 0.46 1.3e-18 Anterior chamber depth; CRC cis rs78761021 0.720 rs874174 chr17:9798619 C/T cg26853458 chr17:9805074 RCVRN -0.39 -7.46 -0.38 7.72e-13 Type 2 diabetes; CRC cis rs881375 0.933 rs7028641 chr9:123691141 G/C cg09586646 chr9:123605570 PSMD5;LOC253039 0.48 6.53 0.34 2.5e-10 Rheumatoid arthritis; CRC cis rs10504229 1.000 rs72650900 chr8:58185675 T/A cg05313129 chr8:58192883 C8orf71 -0.47 -6.99 -0.36 1.49e-11 Developmental language disorder (linguistic errors); CRC cis rs763014 0.593 rs28455838 chr16:681966 T/C cg02475695 chr16:616220 NHLRC4 0.43 6.95 0.36 1.99e-11 Height; CRC cis rs7647973 0.961 rs7638750 chr3:49452957 A/T cg20833759 chr3:49053208 WDR6;DALRD3 -0.54 -7.92 -0.4 3.6e-14 Menarche (age at onset); CRC cis rs13108904 0.935 rs2199956 chr4:1248919 A/G cg00684032 chr4:1343700 KIAA1530 0.4 6.01 0.31 5.02e-9 Obesity-related traits; CRC cis rs62064224 0.593 rs916663 chr17:30835833 A/C cg01480708 chr17:30846118 MYO1D 0.38 6.15 0.32 2.19e-9 Schizophrenia; CRC cis rs12477438 0.715 rs7586608 chr2:99558017 G/A cg14399236 chr2:99771627 LIPT1;TSGA10 -0.59 -8.14 -0.41 8.53e-15 Chronic sinus infection; CRC cis rs9522267 0.535 rs9522298 chr13:112234457 C/A cg14352298 chr13:112236639 NA 0.29 6.67 0.35 1.06e-10 Hepatitis; CRC cis rs2732480 0.500 rs7297824 chr12:48598650 T/C cg04545296 chr12:48745243 ZNF641 0.33 5.86 0.31 1.1e-8 Hemoglobin concentration;Red blood cell count;Hematocrit; CRC cis rs1218582 0.772 rs11264282 chr1:154867370 G/A cg09359103 chr1:154839909 KCNN3 -0.73 -12.95 -0.58 2.92e-31 Prostate cancer; CRC cis rs1862618 0.853 rs190414 chr5:56116772 C/A cg22800045 chr5:56110881 MAP3K1 0.57 6.35 0.33 7.32e-10 Initial pursuit acceleration; CRC cis rs889312 0.500 rs33323 chr5:56175566 C/G cg03609598 chr5:56110824 MAP3K1 -0.44 -6.12 -0.32 2.72e-9 Breast cancer;Breast cancer (early onset); CRC cis rs9914988 0.943 rs66588554 chr17:27141110 A/G cg12682573 chr17:27188876 MIR451;MIR144 0.58 8.06 0.41 1.42e-14 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs4268898 0.636 rs76172309 chr2:24458911 G/C cg06627628 chr2:24431161 ITSN2 -0.85 -11.66 -0.54 1.59e-26 Asthma; CRC cis rs17253792 0.732 rs79014965 chr14:56117551 T/G cg24579896 chr14:56047964 C14orf33;KTN1 0.7 5.6 0.3 4.53e-8 Putamen volume; CRC cis rs3617 0.573 rs9850563 chr3:52912214 G/A cg11645453 chr3:52864694 ITIH4 -0.41 -8.01 -0.4 1.98e-14 Red blood cell count;Autism spectrum disorder or schizophrenia; CRC cis rs11785400 0.793 rs4403386 chr8:143736770 C/G cg10596483 chr8:143751796 JRK 0.43 5.81 0.3 1.51e-8 Schizophrenia; CRC cis rs8180040 0.726 rs34344887 chr3:47042161 A/G cg10298567 chr3:47292165 KIF9 -0.41 -6.57 -0.34 1.96e-10 Colorectal cancer; CRC cis rs1395 0.744 rs11126934 chr2:27476613 T/C cg23587288 chr2:27483067 SLC30A3 -0.39 -6.58 -0.34 1.87e-10 Blood metabolite levels; CRC cis rs539096 0.500 rs2367804 chr1:44314266 C/T cg12908607 chr1:44402522 ARTN -0.55 -10.15 -0.49 3.09e-21 Intelligence (multi-trait analysis); CRC cis rs968567 0.817 rs61896141 chr11:61556039 A/C cg00614641 chr11:61596405 FADS2 -0.59 -7.31 -0.37 2.07e-12 Blood metabolite levels;Rheumatoid arthritis;Vitiligo;Glycerophospholipid levels; CRC cis rs1707322 1.000 rs6676982 chr1:46275401 A/T cg03146154 chr1:46216737 IPP 0.51 7.26 0.37 2.84e-12 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs7428 0.545 rs9248 chr2:85537312 G/A cg24342717 chr2:85555507 TGOLN2 -0.71 -11.57 -0.54 3.41e-26 Ear protrusion; CRC cis rs2502731 0.539 rs3003610 chr9:130985525 G/A cg13642260 chr9:130955380 CIZ1 0.45 7.07 0.36 9.46e-12 Attention deficit hyperactivity disorder; CRC cis rs7809950 0.817 rs17154091 chr7:107084790 T/C cg23024343 chr7:107201750 COG5 -0.75 -10.39 -0.5 4.6e-22 Coronary artery disease; CRC cis rs12594515 0.967 rs11070465 chr15:45984899 A/G cg01629716 chr15:45996671 NA 0.42 8.5 0.42 6.9e-16 Waist circumference;Weight; CRC cis rs798554 0.660 rs2527687 chr7:2838485 G/A cg13628971 chr7:2884303 GNA12 0.43 6.43 0.33 4.4e-10 Height; CRC cis rs752010 0.695 rs11210509 chr1:42109311 A/G cg06885757 chr1:42089581 HIVEP3 0.34 5.73 0.3 2.24e-8 Lupus nephritis in systemic lupus erythematosus; CRC cis rs2625529 0.652 rs2957734 chr15:72261385 A/G cg16672083 chr15:72433130 SENP8 0.48 7.15 0.37 5.76e-12 Red blood cell count; CRC cis rs4332037 0.539 rs11764590 chr7:2032803 C/T cg25834613 chr7:1915315 MAD1L1 -0.48 -6.76 -0.35 6.3e-11 Bipolar disorder; CRC cis rs11864453 0.927 rs1035560 chr16:72032730 T/C cg01557791 chr16:72042693 DHODH -0.53 -7.32 -0.37 1.86e-12 Fibrinogen levels; CRC cis rs6951245 1.000 rs77868187 chr7:1093968 A/C cg18402987 chr7:1209562 NA 0.67 7.26 0.37 2.83e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs6960043 0.905 rs7786873 chr7:15060410 A/G cg19272540 chr7:15055459 NA -0.22 -6.02 -0.31 4.75e-9 Type 2 diabetes; CRC trans rs2303319 0.504 rs12470743 chr2:162611202 G/A cg23247704 chr1:116518985 SLC22A15 -0.72 -6.14 -0.32 2.42e-9 Cognitive function; CRC cis rs57590327 0.503 rs1524557 chr3:81892031 A/G cg07356753 chr3:81810745 GBE1 -0.57 -7.63 -0.39 2.58e-13 Extraversion; CRC cis rs7647973 0.506 rs11920251 chr3:49356671 C/T cg03060546 chr3:49711283 APEH 0.46 6.84 0.35 3.77e-11 Menarche (age at onset); CRC cis rs992157 0.735 rs13392177 chr2:219112956 C/T cg00012203 chr2:219082015 ARPC2 -0.62 -10.32 -0.49 7.83e-22 Colorectal cancer; CRC trans rs7395662 0.963 rs4882072 chr11:48479891 C/T cg21153622 chr11:89784906 NA -0.51 -8.06 -0.41 1.47e-14 HDL cholesterol; CRC trans rs587242 1.000 rs550739 chr1:96887109 G/A cg10631902 chr5:14652156 NA 0.45 6.97 0.36 1.71e-11 Body mass index (joint analysis main effects and physical activity interaction);Body mass index in physically inactive individuals;Body mass index; CRC trans rs2727020 0.681 rs1976901 chr11:49378697 T/C cg21153622 chr11:89784906 NA -0.41 -6.78 -0.35 5.45e-11 Coronary artery disease; CRC cis rs155076 1.000 rs2478824 chr13:21844144 G/C cg25811766 chr13:21894605 NA -0.57 -6.0 -0.31 5.12e-9 White matter hyperintensity burden; CRC cis rs2243480 1.000 rs2420170 chr7:65656053 T/C cg12463550 chr7:65579703 CRCP -0.71 -6.36 -0.33 6.63e-10 Diabetic kidney disease; CRC cis rs7932354 0.528 rs7125807 chr11:47041163 G/T cg03339077 chr11:47165057 C11orf49 -0.45 -6.36 -0.33 6.92e-10 Bone mineral density (hip);Bone mineral density; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg13577407 chr3:57994372 FLNB -0.47 -7.3 -0.37 2.23e-12 Myopia (pathological); CRC cis rs2842992 0.789 rs2842969 chr6:160145364 C/T cg16489826 chr6:160211363 TCP1;MRPL18 0.46 5.67 0.3 3.21e-8 Age-related macular degeneration (geographic atrophy); CRC cis rs1580019 0.563 rs4723169 chr7:32567577 G/A cg14728415 chr7:32535168 LSM5;AVL9 0.44 6.22 0.32 1.55e-9 Cognitive ability; CRC cis rs6758955 1.000 rs73161267 chr2:10478630 C/A cg15773312 chr2:10472214 HPCAL1 -0.73 -9.5 -0.46 4.51e-19 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; CRC cis rs57590327 0.503 rs12497231 chr3:81519291 A/G cg07356753 chr3:81810745 GBE1 0.43 5.6 0.3 4.46e-8 Extraversion; CRC cis rs3733585 0.699 rs6839490 chr4:9965000 C/G cg00071950 chr4:10020882 SLC2A9 0.46 7.89 0.4 4.64e-14 Cleft plate (environmental tobacco smoke interaction); CRC cis rs875971 0.867 rs1002053 chr7:65798545 G/A cg11764359 chr7:65958608 NA -0.64 -10.41 -0.5 4.06e-22 Aortic root size; CRC cis rs6951245 0.554 rs76243429 chr7:1152543 C/T cg24642844 chr7:1081250 C7orf50 -0.47 -6.07 -0.32 3.46e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs35110281 0.591 rs162369 chr21:44931965 G/A cg01579765 chr21:45077557 HSF2BP -0.35 -6.62 -0.34 1.43e-10 Mean corpuscular volume; CRC cis rs2292864 0.764 rs35265764 chr17:45363546 G/T cg18085866 chr17:45331354 ITGB3 -0.57 -5.77 -0.3 1.8e-8 Left atrial antero-posterior diameter; CRC cis rs1223397 0.938 rs3817737 chr6:13279082 A/G cg00460589 chr6:13274354 PHACTR1 0.49 5.89 0.31 9.33e-9 Blood pressure; CRC cis rs1552244 1.000 rs67006488 chr3:10152993 T/C cg13047869 chr3:10149882 C3orf24 0.57 7.76 0.39 1.08e-13 Alzheimer's disease; CRC cis rs4285028 0.699 rs1920298 chr3:121597888 T/C cg11130432 chr3:121712080 ILDR1 -0.5 -6.14 -0.32 2.33e-9 Multiple sclerosis; CRC cis rs9682041 0.627 rs10936625 chr3:170094908 G/T cg11886554 chr3:170076028 SKIL -0.61 -7.46 -0.38 7.97e-13 Glomerular filtration rate in non diabetics (creatinine);Glomerular filtration rate (creatinine); CRC cis rs4474465 0.915 rs12273367 chr11:78173835 A/T cg27205649 chr11:78285834 NARS2 -0.48 -5.85 -0.31 1.18e-8 Alzheimer's disease (survival time); CRC cis rs7927771 0.965 rs56400411 chr11:47586376 T/G cg05585544 chr11:47624801 NA -0.62 -11.41 -0.53 1.22e-25 Subjective well-being; CRC cis rs12701220 0.655 rs6955290 chr7:1151066 A/G cg26240231 chr7:1148101 C7orf50 0.41 6.22 0.32 1.51e-9 Bronchopulmonary dysplasia; CRC cis rs780096 0.526 rs3845687 chr2:27689899 T/C cg24768116 chr2:27665128 KRTCAP3 -0.35 -7.65 -0.39 2.19e-13 Total body bone mineral density; CRC cis rs875971 0.505 rs1723275 chr7:65504633 G/C cg18876405 chr7:65276391 NA -0.65 -11.72 -0.54 9.77e-27 Aortic root size; CRC cis rs265548 0.608 rs36690 chr19:17910483 C/T cg16024904 chr19:17905718 B3GNT3 0.38 5.97 0.31 6.05e-9 Tumor biomarkers; CRC cis rs11628318 0.614 rs3783383 chr14:103177420 G/C cg12046867 chr14:103022105 NA 0.41 6.02 0.32 4.54e-9 Platelet count; CRC cis rs9426691 1 rs9426691 chr1:23484904 A/G cg12483005 chr1:23474871 LUZP1 0.5 7.04 0.36 1.16e-11 Coenzyme Q10 levels; CRC cis rs9354308 0.899 rs2802056 chr6:66546219 C/A cg07460842 chr6:66804631 NA 0.46 5.68 0.3 2.95e-8 Metabolite levels; CRC cis rs801193 0.904 rs4718405 chr7:66254646 A/G cg00343986 chr7:65444356 GUSB 0.43 6.39 0.33 5.69e-10 Aortic root size; CRC cis rs9443645 0.901 rs9359354 chr6:79590385 A/G cg05283184 chr6:79620031 NA -0.58 -9.34 -0.46 1.48e-18 Intelligence (multi-trait analysis); CRC trans rs1814175 0.527 rs10769595 chr11:49638212 A/G cg15704280 chr7:45808275 SEPT13 -0.72 -9.74 -0.47 7.12e-20 Height; CRC cis rs4713118 0.662 rs149946 chr6:27970031 A/C cg02683197 chr6:28174875 NA -0.72 -9.76 -0.47 6.11e-20 Parkinson's disease; CRC cis rs4713675 0.584 rs509539 chr6:33708190 A/C cg14003231 chr6:33640908 ITPR3 -0.39 -6.37 -0.33 6.53e-10 Plateletcrit; CRC cis rs34311866 0.808 rs11248059 chr4:960331 C/G cg14530993 chr4:882597 GAK 0.77 7.01 0.36 1.32e-11 Parkinson's disease; CRC cis rs798554 0.759 rs2644291 chr7:2890456 T/C cg19346786 chr7:2764209 NA -0.42 -7.03 -0.36 1.19e-11 Height; CRC cis rs9435341 0.896 rs1730851 chr1:107596443 A/G cg14828511 chr1:107599125 PRMT6 -0.52 -7.19 -0.37 4.53e-12 Facial morphology (factor 21, depth of nasal alae); CRC cis rs896854 0.548 rs574183 chr8:95973816 A/G cg23172400 chr8:95962367 TP53INP1 0.42 6.34 0.33 7.42e-10 Type 2 diabetes; CRC cis rs9807841 0.592 rs10401513 chr19:10778763 A/T cg17710535 chr19:10819994 QTRT1 0.46 7.12 0.37 6.84e-12 Inflammatory skin disease; CRC cis rs736408 0.716 rs2300149 chr3:52822921 C/T cg18099408 chr3:52552593 STAB1 -0.4 -6.38 -0.33 6.14e-10 Bipolar disorder; CRC cis rs9560113 1.000 rs9555805 chr13:112179765 C/T cg10483660 chr13:112241077 NA 0.36 5.81 0.3 1.49e-8 Menarche (age at onset); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg27350398 chr10:3214550 PITRM1 0.42 6.13 0.32 2.45e-9 Intelligence (multi-trait analysis); CRC cis rs172166 0.694 rs536704 chr6:28092603 T/G cg23161317 chr6:28129485 ZNF389 0.46 6.6 0.34 1.66e-10 Cardiac Troponin-T levels; CRC cis rs9916302 0.718 rs10445306 chr17:37591422 A/G cg03013999 chr17:37608204 MED1 0.47 7.35 0.38 1.61e-12 Glomerular filtration rate (creatinine); CRC cis rs9322193 0.923 rs4354168 chr6:150017778 C/T cg05861140 chr6:150128134 PCMT1 -0.37 -5.96 -0.31 6.32e-9 Lung cancer; CRC cis rs7178572 0.889 rs7177055 chr15:77832762 A/G cg22256960 chr15:77711686 NA 0.59 8.73 0.43 1.34e-16 Type 2 diabetes; CRC cis rs12188164 0.714 rs11741954 chr5:421455 G/T cg26850624 chr5:429559 AHRR -0.77 -12.45 -0.57 1.99e-29 Cystic fibrosis severity; CRC cis rs4901869 0.931 rs12891570 chr14:59334338 T/A cg02291164 chr14:59296302 NA 0.35 6.22 0.32 1.48e-9 Panic disorder; CRC trans rs8073060 0.544 rs8072676 chr17:33999517 C/T cg19694781 chr19:47549865 TMEM160 -1.01 -14.38 -0.62 1.05e-36 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; CRC cis rs919433 0.963 rs7582736 chr2:198170342 A/G cg20885578 chr2:198174922 NA -0.44 -6.99 -0.36 1.5e-11 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC cis rs9875589 0.509 rs2731332 chr3:14110083 G/C cg14375111 chr3:14165186 TMEM43;CHCHD4 0.41 6.01 0.31 4.87e-9 Ovarian reserve; CRC cis rs763014 1.000 rs763014 chr16:675680 T/C cg07343612 chr16:622815 PIGQ -0.81 -13.57 -0.6 1.31e-33 Height; CRC cis rs12476592 0.602 rs11125978 chr2:63809602 C/T cg10828910 chr2:63850056 LOC388955 0.49 6.12 0.32 2.65e-9 Childhood ear infection; CRC cis rs898097 0.841 rs4986122 chr17:80825500 C/T cg16060761 chr17:80687452 NA 0.41 6.0 0.31 5.23e-9 Breast cancer; CRC cis rs8141529 0.509 rs5762853 chr22:29245231 T/G cg15103426 chr22:29168792 CCDC117 0.53 6.95 0.36 2.02e-11 Lymphocyte counts; CRC cis rs950169 1.000 rs35297609 chr15:84772896 A/G cg11189052 chr15:85197271 WDR73 0.61 9.0 0.44 1.87e-17 Schizophrenia; CRC cis rs875971 0.862 rs1981799 chr7:65955559 T/C cg00343986 chr7:65444356 GUSB 0.44 6.39 0.33 5.77e-10 Aortic root size; CRC cis rs4689592 0.523 rs6446565 chr4:7074027 A/G cg26116260 chr4:7069785 GRPEL1 0.96 14.91 0.64 8.72e-39 Monocyte percentage of white cells; CRC trans rs9650657 0.538 rs11250093 chr8:10798828 C/T cg06636001 chr8:8085503 FLJ10661 0.61 8.47 0.42 8.52e-16 Neuroticism; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg04589156 chr19:507132 C19orf20 0.46 6.34 0.33 7.53e-10 Response to antipsychotic treatment; CRC cis rs10504229 0.817 rs78138632 chr8:58191341 G/T cg20607798 chr8:58055168 NA 0.52 5.67 0.3 3.12e-8 Developmental language disorder (linguistic errors); CRC cis rs6460942 0.749 rs62448592 chr7:12435985 A/T cg06484146 chr7:12443880 VWDE -0.78 -8.09 -0.41 1.17e-14 Coronary artery disease; CRC cis rs2739330 0.760 rs5751761 chr22:24243736 A/G cg24846343 chr22:24311635 DDTL -0.68 -10.79 -0.51 1.98e-23 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs798554 0.680 rs2533889 chr7:2900309 G/C cg13628971 chr7:2884303 GNA12 0.52 6.77 0.35 5.8200000000000003e-11 Height; CRC cis rs9322193 0.962 rs9688809 chr6:150109056 C/T cg00933542 chr6:150070202 PCMT1 0.28 5.63 0.3 3.86e-8 Lung cancer; CRC cis rs9814567 1.000 rs13087875 chr3:134261123 C/T cg06109529 chr3:134205091 CEP63;ANAPC13 0.82 12.06 0.55 5.69e-28 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC trans rs1814175 0.645 rs28538913 chr11:50040718 C/T cg11707556 chr5:10655725 ANKRD33B -0.52 -10.16 -0.49 2.82e-21 Height; CRC trans rs1814175 0.519 rs3913237 chr11:49551828 G/A cg15704280 chr7:45808275 SEPT13 0.76 10.14 0.49 3.37e-21 Height; CRC cis rs9818758 0.607 rs11719220 chr3:49245201 A/G cg00383909 chr3:49044727 WDR6 1.07 10.43 0.5 3.41e-22 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; CRC cis rs35110281 0.774 rs2838321 chr21:44995488 A/T cg04455712 chr21:45112962 RRP1B 0.43 8.16 0.41 7.27e-15 Mean corpuscular volume; CRC trans rs3942852 0.550 rs1113480 chr11:48058313 G/T cg03929089 chr4:120376271 NA -0.52 -7.15 -0.37 5.63e-12 Acute lymphoblastic leukemia (childhood); CRC cis rs7267979 0.706 rs6037069 chr20:25234166 C/T cg24626310 chr20:25276739 ABHD12;PYGB 0.34 5.76 0.3 1.92e-8 Liver enzyme levels (alkaline phosphatase); CRC trans rs3857536 0.544 rs208453 chr6:66906841 A/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.66 -8.92 -0.44 3.35e-17 Blood trace element (Cu levels); CRC cis rs77861329 1.000 rs57335685 chr3:52098458 C/T cg08692210 chr3:52188851 WDR51A 0.83 7.38 0.38 1.27e-12 Macrophage inflammatory protein 1b levels; CRC trans rs2403907 0.758 rs2823136 chr21:16571951 G/C cg00407105 chr4:90231041 NA -0.39 -5.97 -0.31 6.07e-9 Breast cancer; CRC cis rs4563143 0.675 rs56123392 chr19:29255631 A/C cg12756686 chr19:29218302 NA 0.6 8.99 0.44 2.04e-17 Methadone dose in opioid dependence; CRC cis rs514406 0.607 rs11206000 chr1:53205923 A/C cg24675658 chr1:53192096 ZYG11B 0.72 11.91 0.55 1.93e-27 Monocyte count; CRC cis rs6496667 0.586 rs7162687 chr15:90889323 C/T cg22089800 chr15:90895588 ZNF774 -0.4 -6.24 -0.33 1.32e-9 Rheumatoid arthritis; CRC cis rs6502050 0.769 rs9916231 chr17:80119645 A/G cg11859384 chr17:80120422 CCDC57 -0.38 -5.9 -0.31 9.19e-9 Life satisfaction; CRC cis rs9322193 0.884 rs9688699 chr6:150054816 A/G cg00933542 chr6:150070202 PCMT1 0.31 6.23 0.32 1.47e-9 Lung cancer; CRC cis rs501120 0.810 rs607592 chr10:44750215 A/G cg09554077 chr10:44749378 NA 0.89 13.17 0.59 4.18e-32 Coronary artery disease;Coronary heart disease; CRC cis rs172166 0.694 rs2791332 chr6:28108788 C/T cg12273811 chr6:28175739 NA 0.58 8.35 0.42 1.92e-15 Cardiac Troponin-T levels; CRC cis rs1552244 1.000 rs9881859 chr3:10072814 A/T cg16606324 chr3:10149918 C3orf24 0.7 9.45 0.46 6.5e-19 Alzheimer's disease; CRC trans rs4650994 1.000 rs4076205 chr1:178534157 G/A cg05059571 chr16:84539110 KIAA1609 -0.42 -6.34 -0.33 7.58e-10 HDL cholesterol levels;HDL cholesterol; CRC cis rs12497850 0.931 rs9311432 chr3:48850443 T/A cg07636037 chr3:49044803 WDR6 1.04 18.72 0.72 9.87e-54 Parkinson's disease; CRC cis rs12472274 0.941 rs4663861 chr2:239105203 C/T cg17459225 chr2:239074497 NA 0.84 14.03 0.61 2.31e-35 Phospholipid levels (plasma); CRC cis rs2228479 0.850 rs11076619 chr16:89831243 C/A cg06656553 chr16:89960601 TCF25 -0.7 -5.84 -0.31 1.23e-8 Skin colour saturation; CRC cis rs1185460 0.967 rs11217137 chr11:118931030 A/G cg23280166 chr11:118938394 VPS11 0.39 5.64 0.3 3.67e-8 Coronary artery disease; CRC cis rs11122272 0.701 rs971533 chr1:231522097 T/C cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.54 -8.14 -0.41 7.99e-15 Hemoglobin concentration; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg01985446 chr10:80830536 ZMIZ1 0.47 6.97 0.36 1.75e-11 Intelligence (multi-trait analysis); CRC cis rs9788333 0.962 rs61951450 chr13:21886354 G/A cg06138931 chr13:21896616 NA 0.54 8.48 0.42 7.47e-16 Thiazide-induced adverse metabolic effects in hypertensive patients; CRC cis rs891088 0.677 rs17253937 chr19:7184801 C/T cg09779027 chr19:7224513 INSR -0.57 -6.15 -0.32 2.26e-9 Hip circumference adjusted for BMI;Height; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg25404025 chr5:52777789 FST 0.43 6.01 0.31 4.93e-9 Response to antipsychotic treatment; CRC trans rs2243480 1.000 rs36068983 chr7:65408991 C/T cg10756647 chr7:56101905 PSPH 0.72 7.98 0.4 2.39e-14 Diabetic kidney disease; CRC cis rs7659604 0.518 rs17452156 chr4:122733623 T/C cg19748678 chr4:122722346 EXOSC9 0.65 10.11 0.49 4.06e-21 Type 2 diabetes; CRC cis rs4819052 0.851 rs28616694 chr21:46674786 G/C cg11663144 chr21:46675770 NA -0.87 -15.07 -0.64 2.15e-39 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC trans rs5417 0.788 rs2654185 chr17:7183362 G/T cg15655154 chr3:113604241 GRAMD1C 0.49 8.3 0.42 2.65e-15 Diastolic blood pressure; CRC cis rs6598955 0.670 rs12733645 chr1:26540356 G/T cg04990556 chr1:26633338 UBXN11 -0.8 -13.28 -0.59 1.56e-32 Obesity-related traits; CRC cis rs72781680 1.000 rs72796359 chr2:24160545 T/C cg08917208 chr2:24149416 ATAD2B 1.03 10.1 0.49 4.66e-21 Lymphocyte counts; CRC cis rs10256972 0.591 rs6950319 chr7:1161324 A/G cg09177884 chr7:1199841 ZFAND2A -0.45 -6.54 -0.34 2.34e-10 Longevity;Endometriosis; CRC cis rs2249694 0.919 rs10857768 chr10:135402703 A/G cg16964102 chr10:135390573 NA 0.45 7.42 0.38 1.02e-12 Obesity-related traits; CRC cis rs7618915 0.547 rs2590846 chr3:52692359 C/G cg07507251 chr3:52567010 NT5DC2 0.42 6.07 0.32 3.47e-9 Bipolar disorder; CRC cis rs35110281 0.776 rs2838316 chr21:44990036 C/T cg04455712 chr21:45112962 RRP1B 0.42 8.32 0.42 2.3e-15 Mean corpuscular volume; CRC cis rs651907 0.557 rs3094296 chr3:101400167 A/G cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.63 8.47 0.42 8.09e-16 Colorectal cancer; CRC cis rs9457247 0.602 rs13204839 chr6:167471119 G/A cg07741184 chr6:167504864 NA 0.44 7.41 0.38 1.11e-12 Crohn's disease; CRC cis rs593982 1.000 rs118030231 chr11:65501905 G/A cg08755490 chr11:65554678 OVOL1 -1.08 -12.43 -0.57 2.49e-29 Atopic dermatitis; CRC cis rs6712932 1.000 rs28521663 chr2:105846716 T/C cg22878388 chr2:105853796 NA -0.3 -5.85 -0.31 1.18e-8 Type 2 diabetes; CRC cis rs9443645 0.901 rs55755815 chr6:79607121 G/T cg09184832 chr6:79620586 NA -0.52 -9.73 -0.47 7.62e-20 Intelligence (multi-trait analysis); CRC cis rs9640161 0.830 rs35635199 chr7:150063342 C/T cg21361702 chr7:150065534 REPIN1 0.44 5.65 0.3 3.45e-8 Blood protein levels;Circulating chemerin levels; CRC cis rs769267 0.930 rs747050 chr19:19584987 C/G cg03709012 chr19:19516395 GATAD2A 0.72 11.24 0.53 4.97e-25 Tonsillectomy; CRC cis rs1577917 0.958 rs11756615 chr6:86679835 G/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.52 -6.5 -0.34 2.98e-10 Response to antipsychotic treatment; CRC cis rs2832191 0.716 rs2297252 chr21:30377104 G/A cg08807101 chr21:30365312 RNF160 0.72 11.56 0.54 3.73e-26 Dental caries; CRC cis rs2495707 0.624 rs2489007 chr10:102422046 A/G cg13834844 chr10:102415320 NA 0.34 5.77 0.3 1.82e-8 Body mass index; CRC cis rs2346177 0.777 rs7587138 chr2:46657089 A/G cg26688816 chr2:46740690 ATP6V1E2 0.52 8.29 0.42 3.02e-15 HDL cholesterol; CRC cis rs4713118 0.513 rs149945 chr6:28002853 T/C cg03623178 chr6:28175578 NA 0.75 11.28 0.53 3.55e-25 Parkinson's disease; CRC cis rs17270561 0.609 rs1165155 chr6:25795577 A/T cg16482183 chr6:26056742 HIST1H1C 0.6 8.12 0.41 9.28e-15 Iron status biomarkers; CRC cis rs798554 0.679 rs2533877 chr7:2882421 G/A cg13628971 chr7:2884303 GNA12 0.61 8.32 0.42 2.34e-15 Height; CRC cis rs6582630 0.502 rs10880388 chr12:38401341 A/T cg26384229 chr12:38710491 ALG10B 0.7 9.81 0.48 4.41e-20 Drug-induced liver injury (flucloxacillin); CRC cis rs73200209 0.744 rs17426676 chr12:116595512 T/C cg01776926 chr12:116560359 MED13L -0.62 -7.21 -0.37 3.98e-12 Total body bone mineral density; CRC cis rs6893807 1.000 rs6893807 chr5:87965021 C/T cg09002922 chr5:87956389 LOC645323 0.41 5.97 0.31 6.32e-9 Body mass index; CRC cis rs875971 0.520 rs12666485 chr7:65625122 T/C cg03233332 chr7:66118400 NA -0.45 -6.22 -0.32 1.49e-9 Aortic root size; CRC cis rs7705042 0.897 rs12515668 chr5:141496090 G/T cg07392085 chr5:141489673 NDFIP1 0.47 7.46 0.38 7.85e-13 Asthma; CRC cis rs1190552 0.846 rs3742437 chr14:102965047 G/A cg18135206 chr14:102964638 TECPR2 0.53 6.31 0.33 9.27e-10 Blood protein levels; CRC cis rs524281 0.773 rs4393319 chr11:66001878 A/T cg14036092 chr11:66035641 RAB1B -0.56 -6.35 -0.33 7.22e-10 Electroencephalogram traits; CRC cis rs7927771 0.524 rs7943213 chr11:47715524 T/C cg20307385 chr11:47447363 PSMC3 0.46 6.7 0.35 8.98e-11 Subjective well-being; CRC trans rs11764590 0.813 rs11768212 chr7:1992582 A/C cg11693508 chr17:37793320 STARD3 0.54 6.44 0.33 4.15e-10 Neuroticism; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg06076054 chr21:19191045 C21orf91 0.51 6.67 0.35 1.09e-10 Thyroid stimulating hormone; CRC cis rs1799949 1.000 rs8176265 chr17:41213996 C/T cg25072359 chr17:41440525 NA 0.46 6.76 0.35 6.26e-11 Menopause (age at onset); CRC cis rs12580194 0.598 rs12582005 chr12:55772837 A/T cg19537932 chr12:55886519 OR6C68 -0.7 -8.89 -0.44 4.21e-17 Cancer; CRC cis rs13191362 0.872 rs73020362 chr6:163005737 A/C cg23758597 chr6:163146217 PARK2 -0.55 -6.13 -0.32 2.54e-9 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC trans rs853679 0.882 rs9380069 chr6:28203300 A/G cg06606381 chr12:133084897 FBRSL1 -0.98 -8.77 -0.44 1.01e-16 Depression; CRC cis rs514406 0.698 rs522259 chr1:53365481 A/G cg24675658 chr1:53192096 ZYG11B -0.7 -10.17 -0.49 2.57e-21 Monocyte count; CRC cis rs185694 1.000 rs672233 chr13:30899601 G/A cg07600127 chr13:30881527 KATNAL1 -0.57 -6.05 -0.32 4.01e-9 Antineutrophil cytoplasmic antibody-associated vasculitis; CRC cis rs7249142 0.597 rs759999 chr19:19281207 A/C cg08207377 chr19:19281140 LOC729991-MEF2B;MEF2B -0.36 -5.83 -0.31 1.34e-8 IgG glycosylation; CRC trans rs2303319 0.504 rs16845945 chr2:162480684 C/T cg03757145 chr4:76555832 CDKL2 -0.67 -5.97 -0.31 6e-9 Cognitive function; CRC trans rs10504229 1.000 rs77823122 chr8:58170161 A/G cg04077850 chr5:125800366 GRAMD3 0.37 6.27 0.33 1.15e-9 Developmental language disorder (linguistic errors); CRC trans rs4285028 0.747 rs7623901 chr3:121529011 A/G cg15837235 chr14:94199997 PRIMA1 -0.39 -6.09 -0.32 3.19e-9 Multiple sclerosis; CRC trans rs1455244 0.700 rs7229302 chr18:11508904 G/T cg14824280 chr20:60718867 SS18L1;PSMA7 0.39 6.31 0.33 9.14e-10 Schizophrenia; CRC cis rs614226 1.000 rs1167727 chr12:120965508 C/A cg27489772 chr12:121021490 NA 0.49 6.91 0.36 2.53e-11 Type 1 diabetes nephropathy; CRC cis rs13064411 0.518 rs9852703 chr3:113189368 C/T cg18753928 chr3:113234510 CCDC52 0.49 7.73 0.39 1.33e-13 Response to simvastatin treatment (PCSK9 protein level change); CRC cis rs7666738 0.830 rs28867388 chr4:98962794 A/T cg05340658 chr4:99064831 C4orf37 0.61 9.45 0.46 6.55e-19 Colonoscopy-negative controls vs population controls; CRC cis rs6598955 0.756 rs10902723 chr1:26568542 T/C cg04990556 chr1:26633338 UBXN11 -0.78 -12.97 -0.58 2.26e-31 Obesity-related traits; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg01089060 chr10:97050836 PDLIM1 -0.38 -6.01 -0.31 4.83e-9 Myopia (pathological); CRC cis rs17345786 0.817 rs11720560 chr3:101328484 C/T cg11279151 chr3:101281821 RG9MTD1 -0.69 -8.53 -0.43 5.56e-16 Colonoscopy-negative controls vs population controls; CRC cis rs3736485 0.844 rs7162412 chr15:51753994 C/T cg08986416 chr15:51914746 DMXL2 -0.46 -6.38 -0.33 6.02e-10 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs35264875 1.000 rs72928652 chr11:68851547 G/A cg23740940 chr11:68924746 NA 0.44 5.75 0.3 2.04e-8 Blond vs. brown hair color; CRC cis rs56104184 0.775 rs73061692 chr19:49399676 T/C cg21252483 chr19:49399788 TULP2 -0.43 -6.62 -0.34 1.49e-10 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; CRC trans rs2797160 1.000 rs1777226 chr6:126017691 C/A cg05039488 chr6:79577232 IRAK1BP1 0.5 7.47 0.38 7.32e-13 Endometrial cancer; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg24568548 chr11:43544500 NA -0.4 -6.38 -0.33 5.88e-10 Liver disease severity in Alagille syndrome; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg00295835 chr11:113644563 ZW10 0.53 7.47 0.38 7.16e-13 Response to antipsychotic treatment; CRC cis rs2404602 0.619 rs7342603 chr15:76982625 C/T cg03037974 chr15:76606532 NA 0.69 12.06 0.55 5.61e-28 Blood metabolite levels; CRC cis rs9796 0.621 rs11858678 chr15:41467932 A/G cg18705301 chr15:41695430 NDUFAF1 -0.44 -7.21 -0.37 3.83e-12 Menopause (age at onset); CRC cis rs6460942 0.841 rs6968277 chr7:12443795 C/A cg20607287 chr7:12443886 VWDE -0.65 -8.46 -0.42 8.6e-16 Coronary artery disease; CRC trans rs875971 0.660 rs2191268 chr7:66110224 C/T cg00869632 chr17:59940709 BRIP1 -0.41 -6.2 -0.32 1.66e-9 Aortic root size; CRC trans rs1814175 0.616 rs10769644 chr11:49987676 C/A cg03929089 chr4:120376271 NA -0.91 -16.17 -0.67 1.06e-43 Height; CRC cis rs736408 0.545 rs6445529 chr3:52662722 T/A cg18404041 chr3:52824283 ITIH1 -0.42 -8.82 -0.44 6.67e-17 Bipolar disorder; CRC cis rs7945705 0.902 rs10743093 chr11:8869129 A/G cg12365402 chr11:9010492 NRIP3 0.46 7.22 0.37 3.6e-12 Hemoglobin concentration; CRC cis rs6570726 0.791 rs446362 chr6:145878716 G/T cg23711669 chr6:146136114 FBXO30 0.77 13.46 0.6 3.42e-33 Lobe attachment (rater-scored or self-reported); CRC cis rs801193 0.548 rs6975044 chr7:66227482 C/T cg11764359 chr7:65958608 NA 0.58 8.65 0.43 2.31e-16 Aortic root size; CRC cis rs2032447 0.933 rs4401650 chr6:26035208 G/A cg03517284 chr6:25882590 NA -0.51 -7.06 -0.36 9.97e-12 Intelligence (multi-trait analysis); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg03047724 chr7:139477895 TBXAS1;HIPK2 0.38 5.98 0.31 5.87e-9 Liver disease severity in Alagille syndrome; CRC cis rs7208487 0.684 rs12449852 chr17:37632088 A/G cg15445000 chr17:37608096 MED1 0.35 6.05 0.32 3.83e-9 Primary biliary cholangitis;Glomerular filtration rate in non diabetics (creatinine); CRC cis rs5766691 1.000 rs4823597 chr22:47531320 A/G cg15757745 chr22:47558489 TBC1D22A 0.43 5.62 0.3 3.97e-8 Longevity; CRC cis rs501120 0.584 rs11238912 chr10:44695909 T/C cg09554077 chr10:44749378 NA 0.69 7.89 0.4 4.55e-14 Coronary artery disease;Coronary heart disease; CRC cis rs6604026 0.656 rs2811590 chr1:93367166 C/A cg17283838 chr1:93427260 FAM69A -0.43 -5.79 -0.3 1.61e-8 Multiple sclerosis; CRC cis rs11212617 0.935 rs183459 chr11:108089197 G/T cg01991180 chr11:108092276 ATM;NPAT 0.42 6.11 0.32 2.81e-9 Response to metformin in type 2 diabetes (glycemic); CRC cis rs6088580 0.634 rs6059880 chr20:33088669 G/A cg24642439 chr20:33292090 TP53INP2 0.39 6.6 0.34 1.68e-10 Glomerular filtration rate (creatinine); CRC cis rs6694672 1.000 rs7411719 chr1:197085676 T/A cg13682187 chr1:196946512 CFHR5 0.43 6.97 0.36 1.69e-11 Asthma; CRC cis rs9487051 0.768 rs463916 chr6:109520538 A/G cg01475377 chr6:109611718 NA -0.34 -5.86 -0.31 1.15e-8 Reticulocyte fraction of red cells; CRC cis rs12148488 0.816 rs11854975 chr15:75363876 C/T cg17294928 chr15:75287854 SCAMP5 0.52 7.87 0.4 5.01e-14 Caffeine consumption; CRC cis rs6460942 0.818 rs7780083 chr7:12233647 C/T cg06484146 chr7:12443880 VWDE -0.58 -6.08 -0.32 3.36e-9 Coronary artery disease; CRC cis rs13064411 0.696 rs2129434 chr3:113138763 A/C cg18753928 chr3:113234510 CCDC52 -0.6 -8.5 -0.42 6.69e-16 Response to simvastatin treatment (PCSK9 protein level change); CRC cis rs10504229 1.000 rs112284078 chr8:58191640 A/G cg01721255 chr8:58191610 C8orf71 0.5 6.06 0.32 3.65e-9 Developmental language disorder (linguistic errors); CRC cis rs6921919 0.583 rs9468355 chr6:28341877 A/G cg21251018 chr6:28226885 NKAPL 0.39 5.63 0.3 3.88e-8 Autism spectrum disorder or schizophrenia; CRC cis rs6502050 0.835 rs7219180 chr17:80079968 C/G cg25804541 chr17:80189381 SLC16A3 0.31 6.01 0.31 4.93e-9 Life satisfaction; CRC trans rs916888 0.821 rs199512 chr17:44857352 T/C cg07870213 chr5:140052090 DND1 -0.85 -10.09 -0.49 4.88e-21 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs10504229 0.775 rs17805026 chr8:58160637 A/C cg21724239 chr8:58056113 NA 0.64 8.48 0.42 8e-16 Developmental language disorder (linguistic errors); CRC cis rs6860806 0.661 rs2136187 chr5:131577894 T/C cg11843238 chr5:131593191 PDLIM4 0.43 8.17 0.41 6.74e-15 Breast cancer; CRC cis rs7615952 0.599 rs7652883 chr3:125707977 T/G cg06494592 chr3:125709126 NA -0.55 -6.68 -0.35 1.03e-10 Blood pressure (smoking interaction); CRC cis rs9443645 0.901 rs1542977 chr6:79550307 G/T cg11833968 chr6:79620685 NA -0.34 -5.98 -0.31 5.89e-9 Intelligence (multi-trait analysis); CRC cis rs79387448 0.745 rs7601773 chr2:103120483 G/T cg00507830 chr2:103233733 NA 0.5 5.63 0.3 3.86e-8 Gut microbiota (bacterial taxa); CRC cis rs11023332 0.832 rs10832289 chr11:14669496 A/T cg19336497 chr11:14380999 RRAS2 0.34 5.77 0.3 1.86e-8 Adiponectin levels;Vitamin D levels; CRC cis rs9894429 0.646 rs7405870 chr17:79617284 G/A cg21028142 chr17:79581711 NPLOC4 0.35 7.12 0.37 7.03e-12 Eye color traits; CRC cis rs6674176 0.593 rs3791120 chr1:44431715 T/C cg15962314 chr1:44399869 ARTN 0.3 5.76 0.3 1.94e-8 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Cognitive ability; CRC cis rs10504229 0.683 rs55807014 chr8:58131801 T/C cg04204079 chr8:58130323 NA -0.45 -5.78 -0.3 1.71e-8 Developmental language disorder (linguistic errors); CRC cis rs7927771 1.000 rs10838738 chr11:47663049 A/G cg18512352 chr11:47633146 NA -0.48 -9.59 -0.47 2.21e-19 Subjective well-being; CRC cis rs28386778 0.897 rs7221853 chr17:61859836 A/G cg23090583 chr17:61904693 PSMC5;FTSJ3 1.05 20.29 0.75 6.44e-60 Prudent dietary pattern; CRC cis rs875971 0.789 rs7808013 chr7:66071196 A/G cg11764359 chr7:65958608 NA -0.59 -8.76 -0.43 1.09e-16 Aortic root size; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg20408290 chr12:68042072 DYRK2 0.43 6.49 0.34 3.15e-10 Intelligence (multi-trait analysis); CRC cis rs9916302 0.784 rs4795382 chr17:37700860 A/G cg15445000 chr17:37608096 MED1 0.43 9.43 0.46 7.8e-19 Glomerular filtration rate (creatinine); CRC cis rs1799949 1.000 rs67060599 chr17:41255102 A/G cg19454999 chr17:41278357 BRCA1;NBR2 0.55 8.54 0.43 5.06e-16 Menopause (age at onset); CRC cis rs7119 0.604 rs939488 chr15:77867780 T/C cg10437265 chr15:77819839 NA -0.54 -9.05 -0.45 1.27e-17 Type 2 diabetes; CRC cis rs6424115 0.965 rs2502986 chr1:24135292 G/T cg10978503 chr1:24200527 CNR2 0.47 8.59 0.43 3.61e-16 Immature fraction of reticulocytes; CRC cis rs10504229 0.683 rs56196593 chr8:58141898 G/A cg21724239 chr8:58056113 NA 0.49 6.75 0.35 6.76e-11 Developmental language disorder (linguistic errors); CRC cis rs60871478 0.679 rs6962050 chr7:817201 A/G cg13844804 chr7:814759 HEATR2 0.69 8.06 0.41 1.39e-14 Cerebrospinal P-tau181p levels; CRC cis rs1975974 1.000 rs67946006 chr17:21723940 T/C cg18423549 chr17:21743878 NA -0.65 -9.08 -0.45 1.01e-17 Psoriasis; CRC cis rs832540 0.512 rs33320 chr5:56206529 C/T cg12311346 chr5:56204834 C5orf35 -0.56 -8.36 -0.42 1.76e-15 Coronary artery disease; CRC cis rs7539624 0.588 rs10916600 chr1:223897012 C/T cg10100437 chr1:223903862 CAPN2 0.42 5.68 0.3 2.96e-8 Schizophrenia; CRC cis rs2882667 0.931 rs7720150 chr5:138334069 C/A cg09476006 chr5:138032270 NA 0.41 6.61 0.34 1.58e-10 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs6860806 0.661 rs2136187 chr5:131577894 T/C cg02033258 chr5:131593261 PDLIM4 0.41 7.89 0.4 4.41e-14 Breast cancer; CRC cis rs2404602 0.672 rs35374222 chr15:77071394 G/T cg03037974 chr15:76606532 NA -0.53 -7.71 -0.39 1.49e-13 Blood metabolite levels; CRC trans rs4263408 0.934 rs9683743 chr4:39703194 A/C cg10239186 chr6:166756509 SFT2D1 -0.41 -6.17 -0.32 2.03e-9 Plasma amyloid beta peptide concentrations (ABx-40); CRC cis rs12142240 0.698 rs1475388 chr1:46816465 G/A cg14993813 chr1:46806288 NSUN4 -0.5 -6.4 -0.33 5.38e-10 Menopause (age at onset); CRC cis rs34779708 0.931 rs11010130 chr10:35513307 T/C cg03585969 chr10:35415529 CREM 0.56 7.51 0.38 5.59e-13 Inflammatory bowel disease;Crohn's disease; CRC cis rs634534 0.562 rs661335 chr11:65754061 G/A cg26695010 chr11:65641043 EFEMP2 -0.4 -6.07 -0.32 3.5e-9 Sum eosinophil basophil counts;Eosinophil counts; CRC cis rs4665809 0.549 rs17527979 chr2:26428132 A/G cg25036284 chr2:26402008 FAM59B -0.68 -8.22 -0.41 4.87e-15 Gut microbiome composition (summer); CRC cis rs4285028 0.948 rs35902163 chr3:121649526 G/A cg11130432 chr3:121712080 ILDR1 -0.48 -5.96 -0.31 6.46e-9 Multiple sclerosis; CRC cis rs459571 0.959 rs392134 chr9:136909008 G/A cg13789015 chr9:136890014 NCRNA00094 0.45 5.84 0.31 1.26e-8 Platelet distribution width; CRC cis rs4664293 0.647 rs7576644 chr2:160441458 T/C cg08347373 chr2:160653686 CD302 -0.39 -6.48 -0.34 3.41e-10 Monocyte percentage of white cells; CRC cis rs9916302 0.898 rs8072297 chr17:37478048 A/T cg00129232 chr17:37814104 STARD3 0.51 7.37 0.38 1.39e-12 Glomerular filtration rate (creatinine); CRC cis rs7089973 0.872 rs11818115 chr10:116634891 G/A cg23260525 chr10:116636907 FAM160B1 0.32 6.81 0.35 4.75e-11 Bipolar disorder or attention deficit hyperactivity disorder; CRC cis rs2019137 0.560 rs10175462 chr2:113988492 G/A cg19083407 chr2:113993142 PAX8;LOC440839;LOC654433 0.57 8.55 0.43 4.87e-16 Lymphocyte counts; CRC cis rs7618501 0.699 rs2681780 chr3:49897830 C/T cg24110177 chr3:50126178 RBM5 -0.47 -6.83 -0.35 4.06e-11 Intelligence (multi-trait analysis); CRC cis rs4481887 0.927 rs4244173 chr1:248466899 G/C cg00666640 chr1:248458726 OR2T12 0.51 9.1 0.45 8.8e-18 Common traits (Other); CRC cis rs727505 1.000 rs9655845 chr7:124513355 G/C cg23710748 chr7:124431027 NA -0.79 -14.17 -0.62 6.42e-36 Lewy body disease; CRC cis rs10911363 0.573 rs2761580 chr1:183516989 A/T cg09173681 chr1:183549694 NCF2 0.77 10.75 0.51 2.58e-23 Systemic lupus erythematosus; CRC trans rs4714291 0.802 rs2983140 chr6:40017224 A/G cg02267698 chr19:7991119 CTXN1 -0.51 -6.94 -0.36 2.15e-11 Strep throat; CRC cis rs853679 0.517 rs9357063 chr6:28060005 G/A cg25164649 chr6:28176230 NA 0.74 9.26 0.45 2.64e-18 Depression; CRC cis rs9311474 0.508 rs6788887 chr3:52605005 T/C cg08222913 chr3:52553049 STAB1 -0.34 -6.45 -0.34 4e-10 Electroencephalogram traits; CRC cis rs55692411 0.537 rs62262118 chr3:50003586 G/A cg24110177 chr3:50126178 RBM5 -0.48 -5.62 -0.3 3.97e-8 Intelligence (multi-trait analysis); CRC cis rs644799 1.000 rs566204 chr11:95580926 G/A cg03916912 chr11:95522834 CEP57;FAM76B 0.94 18.0 0.7 6.75e-51 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs1448094 0.817 rs10863111 chr12:86330615 T/C cg18827107 chr12:86230957 RASSF9 -0.42 -6.62 -0.34 1.48e-10 Major depressive disorder; CRC cis rs4713118 0.669 rs200997 chr6:27811815 G/A cg08798685 chr6:27730294 NA -0.41 -6.0 -0.31 5.1e-9 Parkinson's disease; CRC trans rs17685 0.753 rs6976532 chr7:75681094 A/G cg19862616 chr7:65841803 NCRNA00174 0.98 19.19 0.73 1.36e-55 Coffee consumption;Coffee consumption (cups per day); CRC cis rs9916302 0.904 rs2061338 chr17:37421767 T/C cg00129232 chr17:37814104 STARD3 -0.54 -8.07 -0.41 1.31e-14 Glomerular filtration rate (creatinine); CRC cis rs10504229 0.683 rs7816733 chr8:58129855 G/A cg21724239 chr8:58056113 NA 0.49 6.81 0.35 4.75e-11 Developmental language disorder (linguistic errors); CRC cis rs6840360 0.533 rs13121178 chr4:152729047 T/C cg09659197 chr4:152720779 NA -0.41 -8.15 -0.41 7.55e-15 Intelligence (multi-trait analysis); CRC cis rs1799949 0.965 rs11656945 chr17:41330265 A/G cg01879757 chr17:41196368 BRCA1 -0.41 -6.18 -0.32 1.86e-9 Menopause (age at onset); CRC cis rs6570726 0.846 rs441575 chr6:145849205 A/C cg23711669 chr6:146136114 FBXO30 0.68 12.3 0.56 7.07e-29 Lobe attachment (rater-scored or self-reported); CRC trans rs208520 0.690 rs12201219 chr6:66748862 A/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 1.05 14.83 0.63 1.81e-38 Exhaled nitric oxide output; CRC cis rs7119 0.651 rs12917431 chr15:77850184 C/G cg27398640 chr15:77910606 LINGO1 -0.41 -6.95 -0.36 1.94e-11 Type 2 diabetes; CRC cis rs6543140 0.964 rs6543136 chr2:103065547 G/A cg04239558 chr2:103089729 SLC9A4 0.38 6.57 0.34 1.92e-10 Blood protein levels; CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg21676273 chr3:45635931 LIMD1 -0.51 -6.18 -0.32 1.92e-9 Diisocyanate-induced asthma; CRC trans rs7615952 0.932 rs7629977 chr3:125649573 T/G cg02560186 chr11:3602584 NA -0.45 -6.12 -0.32 2.62e-9 Blood pressure (smoking interaction); CRC cis rs2992756 1.000 rs2992756 chr1:18807339 T/C cg05040210 chr1:18807594 KLHDC7A -0.43 -7.61 -0.39 2.89e-13 Breast cancer; CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg08695707 chr1:197871847 C1orf53 -0.52 -6.26 -0.33 1.18e-9 Diisocyanate-induced asthma; CRC cis rs7937682 0.889 rs1784786 chr11:111486043 A/G cg19812747 chr11:111475976 SIK2 0.56 9.78 0.47 5.36e-20 Primary sclerosing cholangitis; CRC cis rs2576037 0.526 rs10853547 chr18:44530548 A/C cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.63 -9.94 -0.48 1.63e-20 Personality dimensions; CRC cis rs1190596 0.689 rs2224460 chr14:102563797 A/T cg18135206 chr14:102964638 TECPR2 -0.42 -5.65 -0.3 3.49e-8 Behavioural disinhibition (generation interaction); CRC cis rs735539 1.000 rs2290143 chr13:21280363 A/G cg27499820 chr13:21296301 IL17D -0.38 -6.2 -0.32 1.65e-9 Dental caries; CRC cis rs8060686 0.546 rs8047978 chr16:68143598 T/G cg26727032 chr16:67993705 SLC12A4 -0.62 -9.66 -0.47 1.32e-19 HDL cholesterol;Metabolic syndrome; CRC cis rs9928842 0.770 rs8048371 chr16:75275547 C/T cg08657710 chr16:75258780 CTRB1 -0.58 -6.89 -0.36 2.82e-11 Alcoholic chronic pancreatitis; CRC cis rs10751667 0.666 rs7950967 chr11:955638 G/A cg01483505 chr11:975446 AP2A2 0.45 7.44 0.38 9.1e-13 Alzheimer's disease (late onset); CRC cis rs282587 0.569 rs192530 chr13:113388303 A/G cg04656015 chr13:113407548 ATP11A 0.63 7.73 0.39 1.36e-13 Glycated hemoglobin levels; CRC trans rs9650657 0.538 rs6984496 chr8:10796093 G/T cg06636001 chr8:8085503 FLJ10661 -0.59 -8.97 -0.44 2.29e-17 Neuroticism; CRC trans rs9467711 0.659 rs35555795 chr6:26509382 C/T cg06606381 chr12:133084897 FBRSL1 -1.07 -7.41 -0.38 1.09e-12 Autism spectrum disorder or schizophrenia; CRC cis rs6964587 0.934 rs7811328 chr7:91720931 A/T cg17063962 chr7:91808500 NA 0.77 13.56 0.6 1.34e-33 Breast cancer; CRC trans rs11105468 0.961 rs11105439 chr12:90251760 A/G cg23572944 chr11:60720130 SLC15A3 -0.42 -6.04 -0.32 4.2e-9 Febrile seizures;Febrile seizures (MMR vaccine-related);Febrile seizures (MMR vaccine-unrelated); CRC cis rs7223966 1.000 rs8075521 chr17:61804954 C/T cg05941027 chr17:61774174 LIMD2 0.36 6.4 0.33 5.23e-10 Hip circumference adjusted for BMI;Body mass index; CRC cis rs644799 0.648 rs1255178 chr11:95471908 A/G cg03916912 chr11:95522834 CEP57;FAM76B 0.57 8.95 0.44 2.65e-17 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs17592366 0.517 rs7156153 chr14:35308074 G/A cg09327582 chr14:35236912 BAZ1A 0.48 6.86 0.35 3.36e-11 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells; CRC cis rs8062405 0.755 rs1074631 chr16:28554108 A/G cg16576597 chr16:28551801 NUPR1 -0.51 -7.21 -0.37 3.75e-12 Cognitive ability (multi-trait analysis);Cognitive ability; CRC trans rs10982213 0.830 rs2274163 chr9:117188714 C/T cg16800975 chr8:17434541 PDGFRL 0.47 7.22 0.37 3.53e-12 Interleukin-6 levels; CRC cis rs1691799 0.867 rs1168316 chr12:66746239 A/G cg16791601 chr12:66731901 HELB -0.73 -12.99 -0.58 1.9e-31 White blood cell count (basophil); CRC cis rs1707322 0.752 rs28438704 chr1:46170544 G/A cg06784218 chr1:46089804 CCDC17 0.66 12.38 0.56 3.81e-29 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs12701220 0.947 rs1007765 chr7:1032805 G/C cg00990874 chr7:1149470 C7orf50 -0.6 -7.01 -0.36 1.35e-11 Bronchopulmonary dysplasia; CRC trans rs7517126 0.858 rs12740961 chr1:196660733 C/T cg00574530 chr5:134872064 NEUROG1 0.46 6.01 0.31 5.06e-9 Blood protein levels; CRC cis rs875971 1.000 rs778685 chr7:65836176 G/T cg12463550 chr7:65579703 CRCP 0.48 6.96 0.36 1.89e-11 Aortic root size; CRC cis rs669446 0.562 rs10890273 chr1:44186444 T/A cg12908607 chr1:44402522 ARTN -0.33 -5.74 -0.3 2.1e-8 Amyotrophic lateral sclerosis (age of onset); CRC cis rs798554 0.591 rs1182193 chr7:2869240 A/G cg19717773 chr7:2847554 GNA12 -0.4 -6.7 -0.35 8.89e-11 Height; CRC cis rs1218582 0.741 rs11264281 chr1:154867221 A/G cg09359103 chr1:154839909 KCNN3 -0.76 -13.0 -0.58 1.78e-31 Prostate cancer; CRC cis rs2072510 0.569 rs2540488 chr12:96426745 G/A cg09636302 chr12:96389483 HAL -0.52 -6.5 -0.34 3.07e-10 Metabolite levels (small molecules and protein measures); CRC cis rs9354308 0.899 rs2814153 chr6:66557611 T/A cg07460842 chr6:66804631 NA 0.46 5.77 0.3 1.81e-8 Metabolite levels; CRC cis rs12701220 0.553 rs9639882 chr7:1133731 G/A cg04498913 chr7:1135747 C7orf50 -0.48 -5.88 -0.31 1.02e-8 Bronchopulmonary dysplasia; CRC cis rs7124681 0.546 rs7941399 chr11:47890421 A/T cg20307385 chr11:47447363 PSMC3 0.45 6.61 0.34 1.51e-10 Body mass index (joint analysis main effects and physical activity interaction);Body mass index;Body mass index in physically active individuals; CRC cis rs6604026 0.778 rs11810111 chr1:93278769 C/T cg22128645 chr1:93425802 FAM69A -0.4 -5.63 -0.3 3.91e-8 Multiple sclerosis; CRC cis rs6963495 0.818 rs6956234 chr7:105149707 A/G cg13798780 chr7:105162888 PUS7 0.66 8.06 0.41 1.39e-14 Bipolar disorder (body mass index interaction); CRC cis rs8077889 1.000 rs17674998 chr17:41879544 A/G cg16892393 chr17:41919603 NA 0.5 7.21 0.37 3.87e-12 Triglycerides; CRC cis rs8130944 0.859 rs11702318 chr21:44112366 C/T cg23590273 chr21:44105265 PDE9A -0.35 -5.62 -0.3 3.99e-8 Perceived unattractiveness to mosquitoes; CRC cis rs34526934 0.608 rs34720456 chr2:177027292 G/A cg25347419 chr2:177043501 NA -0.48 -6.43 -0.33 4.54e-10 Obstructive sleep apnea trait (apnea hypopnea index); CRC cis rs889312 0.500 rs832570 chr5:56156408 G/A cg18230493 chr5:56204884 C5orf35 -0.38 -5.63 -0.3 3.96e-8 Breast cancer;Breast cancer (early onset); CRC trans rs1814175 0.817 rs1818890 chr11:49856882 T/C cg03929089 chr4:120376271 NA -0.92 -17.29 -0.69 4.09e-48 Height; CRC cis rs2645694 0.626 rs2703136 chr4:77828957 T/A cg18351406 chr4:77819688 ANKRD56 0.5 7.58 0.39 3.58e-13 Emphysema distribution in smoking; CRC cis rs6952808 0.689 rs4719391 chr7:2048136 T/C cg04267008 chr7:1944627 MAD1L1 -0.7 -10.14 -0.49 3.39e-21 Bipolar disorder and schizophrenia; CRC cis rs2354432 0.607 rs894469 chr1:146672906 C/T cg25205988 chr1:146714368 CHD1L 1.12 9.49 0.46 4.98e-19 Mitochondrial DNA levels; CRC cis rs7224685 0.501 rs1878332 chr17:3904446 G/A cg09597638 chr17:3907349 NA 0.71 13.21 0.59 3.02e-32 Type 2 diabetes; CRC cis rs4664293 0.867 rs7589941 chr2:160584100 G/A cg08347373 chr2:160653686 CD302 -0.47 -7.43 -0.38 9.32e-13 Monocyte percentage of white cells; CRC cis rs9733 0.818 rs7520022 chr1:150659173 C/G cg17724175 chr1:150552817 MCL1 -0.43 -6.67 -0.34 1.11e-10 Tonsillectomy; CRC cis rs57221529 0.766 rs72706606 chr5:558609 T/C cg09021430 chr5:549028 NA -0.72 -8.17 -0.41 6.5e-15 Lung disease severity in cystic fibrosis; CRC cis rs17127169 0.649 rs112466883 chr1:65471020 G/A cg01340542 chr1:65468273 NA 0.82 5.63 0.3 3.85e-8 Sitting height ratio; CRC cis rs826838 1.000 rs11168505 chr12:38939057 A/T cg13010199 chr12:38710504 ALG10B -0.45 -6.11 -0.32 2.8e-9 Heart rate; CRC cis rs6952808 0.895 rs4513875 chr7:1928159 C/T cg20295408 chr7:1910781 MAD1L1 -0.45 -6.29 -0.33 9.93e-10 Bipolar disorder and schizophrenia; CRC cis rs4713118 0.826 rs2893929 chr6:27738732 A/T cg20933634 chr6:27740509 NA 0.63 7.31 0.37 2.09e-12 Parkinson's disease; CRC cis rs807669 0.835 rs698423 chr22:19197896 T/C cg02655711 chr22:19163373 SLC25A1 0.98 20.3 0.75 5.9e-60 Metabolite levels; CRC cis rs17345786 0.906 rs72940399 chr3:101122575 A/T cg12386194 chr3:101231763 SENP7 0.56 7.29 0.37 2.35e-12 Colonoscopy-negative controls vs population controls; CRC cis rs11719291 0.831 rs11715177 chr3:48763894 G/A cg00383909 chr3:49044727 WDR6 0.9 9.03 0.45 1.47e-17 Cognitive function; CRC cis rs7647973 0.577 rs6446247 chr3:49102001 A/T cg07636037 chr3:49044803 WDR6 0.88 10.93 0.52 6.51e-24 Menarche (age at onset); CRC trans rs3960554 0.932 rs4728614 chr7:75841589 A/G cg19862616 chr7:65841803 NCRNA00174 -0.69 -7.85 -0.4 5.78e-14 Eotaxin levels; CRC cis rs9814567 0.806 rs4519744 chr3:134321523 T/C cg06541857 chr3:134203789 ANAPC13;CEP63 -0.37 -5.73 -0.3 2.3e-8 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs11190604 1.000 rs4919464 chr10:102221195 A/G cg07570687 chr10:102243282 WNT8B 0.44 5.66 0.3 3.36e-8 Palmitoleic acid (16:1n-7) levels; CRC cis rs853679 0.513 rs9468296 chr6:28113730 A/G cg02631126 chr6:28058918 ZSCAN12L1 0.29 5.91 0.31 8.38e-9 Depression; CRC cis rs858239 0.712 rs199650 chr7:23367189 C/T cg00469287 chr7:23338798 C7orf30 -0.44 -6.08 -0.32 3.41e-9 Cerebrospinal fluid biomarker levels; CRC trans rs1814175 0.754 rs28593359 chr11:50042357 C/T cg03929089 chr4:120376271 NA -0.93 -17.98 -0.7 7.84e-51 Height; CRC cis rs4665809 1.000 rs11126375 chr2:26344787 G/A cg26119090 chr2:26468346 HADHA;HADHB -0.61 -7.88 -0.4 4.97e-14 Gut microbiome composition (summer); CRC cis rs28829049 0.535 rs12565185 chr1:19498309 G/A cg13387374 chr1:19411106 UBR4 0.4 5.86 0.31 1.15e-8 QRS duration in Tripanosoma cruzi seropositivity; CRC cis rs2463822 0.583 rs72919467 chr11:62040102 G/A cg06239285 chr11:62104954 ASRGL1 -0.78 -7.89 -0.4 4.65e-14 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs910316 1.000 rs175442 chr14:75603564 T/C cg11812906 chr14:75593930 NEK9 -0.57 -8.9 -0.44 3.92e-17 Height; CRC cis rs9611565 0.512 rs4512 chr22:42206084 G/C cg17554472 chr22:41940697 POLR3H -0.56 -5.66 -0.3 3.22e-8 Vitiligo; CRC cis rs524281 0.954 rs549187 chr11:65898631 C/T cg16950941 chr11:66035639 RAB1B -0.61 -8.7 -0.43 1.62e-16 Electroencephalogram traits; CRC cis rs1215050 0.740 rs9994227 chr4:98767094 T/G cg05340658 chr4:99064831 C4orf37 0.46 6.75 0.35 6.5500000000000006e-11 Waist-to-hip ratio adjusted for body mass index; CRC cis rs910316 0.737 rs424120 chr14:75482828 G/T cg08847533 chr14:75593920 NEK9 -0.85 -14.43 -0.62 6.29e-37 Height; CRC cis rs6735179 0.798 rs12475777 chr2:1773830 A/G cg26137290 chr2:1776737 NA 0.46 6.17 0.32 1.98e-9 Response to antipsychotic treatment; CRC cis rs11148252 0.532 rs9536185 chr13:53179801 G/A cg02158880 chr13:53174818 NA 0.67 10.31 0.49 9.09e-22 Lewy body disease; CRC cis rs644799 0.635 rs10831428 chr11:95508404 C/A cg25622487 chr11:95524042 FAM76B;CEP57 0.8 13.17 0.59 4.16e-32 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC trans rs6550704 0.687 rs9865314 chr3:22634337 A/G cg03289576 chr1:249153005 ZNF692 -0.46 -6.71 -0.35 8.32e-11 Daytime sleep phenotypes; CRC cis rs60843830 1.000 rs6709534 chr2:217334 G/C cg25945732 chr2:264204 ACP1;SH3YL1 0.73 11.66 0.54 1.58e-26 Spherical equivalent (joint analysis main effects and education interaction); CRC cis rs72945132 0.882 rs7935969 chr11:70194175 G/A cg00319359 chr11:70116639 PPFIA1 0.56 6.1 0.32 2.93e-9 Coronary artery disease; CRC cis rs9648716 1.000 rs6976462 chr7:140636922 T/A cg10747023 chr7:140774559 NA 0.46 5.99 0.31 5.41e-9 Type 2 diabetes; CRC cis rs589448 0.872 rs315111 chr12:69784695 G/A cg20891283 chr12:69753455 YEATS4 0.98 20.97 0.76 1.32e-62 Cerebrospinal fluid biomarker levels; CRC cis rs4555082 0.834 rs2816624 chr14:105733909 A/G cg18132624 chr14:105716052 BTBD6;BRF1 -0.47 -7.51 -0.38 5.64e-13 Mean platelet volume;Platelet distribution width; CRC cis rs6973256 0.897 rs10954422 chr7:133327587 G/A cg10665199 chr7:133106180 EXOC4 -0.37 -5.69 -0.3 2.77e-8 Intelligence (multi-trait analysis); CRC cis rs11039131 0.629 rs67871383 chr11:47335838 T/C cg20307385 chr11:47447363 PSMC3 -0.45 -6.05 -0.32 3.87e-9 Schizophrenia; CRC cis rs9463078 0.605 rs4711799 chr6:44765780 A/T cg25276700 chr6:44698697 NA 0.26 6.43 0.33 4.37e-10 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; CRC cis rs875971 1.000 rs2420168 chr7:65630631 C/G cg00343986 chr7:65444356 GUSB -0.46 -6.75 -0.35 6.76e-11 Aortic root size; CRC cis rs2836974 0.897 rs8128102 chr21:40606414 G/A cg17971929 chr21:40555470 PSMG1 0.81 11.62 0.54 2.27e-26 Cognitive function; CRC cis rs3820068 0.581 rs67806552 chr1:15927138 T/C cg13390004 chr1:15929781 NA 0.5 7.16 0.37 5.45e-12 Systolic blood pressure; CRC cis rs11608355 0.545 rs7315846 chr12:109908617 T/C cg05360138 chr12:110035743 NA 0.78 8.75 0.43 1.15e-16 Neuroticism; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg14036097 chr4:190862158 FRG1 -0.4 -6.19 -0.32 1.82e-9 Myopia (pathological); CRC cis rs4466137 1.000 rs1154888 chr5:82977410 C/A cg15083037 chr5:83017644 HAPLN1 -0.46 -5.97 -0.31 6.03e-9 Prostate cancer; CRC trans rs2243480 0.803 rs423187 chr7:65509499 G/C cg10756647 chr7:56101905 PSPH 0.78 7.9 0.4 4.13e-14 Diabetic kidney disease; CRC cis rs4481887 0.927 rs6689193 chr1:248482900 T/A cg13385794 chr1:248469461 NA 0.38 6.68 0.35 1.01e-10 Common traits (Other); CRC trans rs1325598 0.935 rs10798483 chr1:176799143 C/T cg03992096 chr13:114928177 NA -0.38 -6.08 -0.32 3.26e-9 Height; CRC trans rs9929218 1.000 rs9937664 chr16:68784603 T/C cg04657470 chr2:198365150 HSPE1;HSPD1 -0.94 -13.28 -0.59 1.58e-32 Colorectal cancer; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg08922075 chr1:65886896 LEPR;LEPROT 0.41 6.11 0.32 2.89e-9 Liver disease severity in Alagille syndrome; CRC cis rs9826463 0.757 rs73240323 chr3:142294803 T/A cg20824294 chr3:142316082 PLS1 0.42 7.0 0.36 1.42e-11 QRS duration in Tripanosoma cruzi seropositivity; CRC cis rs1215050 0.791 rs1727278 chr4:98853576 A/G cg05340658 chr4:99064831 C4orf37 -0.48 -7.21 -0.37 3.82e-12 Waist-to-hip ratio adjusted for body mass index; CRC cis rs7772486 0.686 rs1337839 chr6:146010239 A/G cg05347473 chr6:146136440 FBXO30 -0.39 -5.91 -0.31 8.4e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs76878669 0.561 rs2279861 chr11:66133336 A/G cg18002602 chr11:66138449 SLC29A2 0.28 6.03 0.32 4.42e-9 Educational attainment (years of education); CRC cis rs4925540 0.926 rs10924896 chr1:247196731 T/C cg22502715 chr1:247171572 ZNF695 0.4 5.65 0.3 3.42e-8 Response to taxane treatment (docetaxel); CRC cis rs763014 0.932 rs34498660 chr16:666149 A/G cg02475695 chr16:616220 NHLRC4 0.48 7.96 0.4 2.73e-14 Height; CRC cis rs1930961 1.000 rs6004667 chr22:25874464 A/G cg19660720 chr22:25960296 ADRBK2 -0.53 -6.94 -0.36 2.1e-11 Bipolar disorder with mood-incongruent psychosis; CRC cis rs1915146 0.967 rs7086481 chr10:126844523 A/T cg17191109 chr10:126851326 NA -0.46 -7.02 -0.36 1.25e-11 Menarche (age at onset); CRC cis rs7937682 0.855 rs7934922 chr11:111500026 T/C cg09085632 chr11:111637200 PPP2R1B -0.99 -19.25 -0.73 7.85e-56 Primary sclerosing cholangitis; CRC cis rs9292777 0.520 rs10036697 chr5:40451363 G/A cg09067459 chr5:40385259 NA -0.4 -6.63 -0.34 1.41e-10 Crohn's disease;Multiple sclerosis; CRC cis rs6908034 0.607 rs73378506 chr6:19819987 T/C cg02682789 chr6:19804855 NA 0.61 5.82 0.31 1.41e-8 Endometriosis;Deep ovarian and/or rectovaginal disease with dense adhesions; CRC cis rs684232 0.602 rs331008 chr17:544617 C/T cg15660573 chr17:549704 VPS53 -0.86 -15.78 -0.66 3.56e-42 Prostate cancer; CRC cis rs4665809 0.590 rs35532350 chr2:26441605 T/C cg22920501 chr2:26401640 FAM59B -0.83 -11.96 -0.55 1.28e-27 Gut microbiome composition (summer); CRC cis rs995000 0.965 rs3913007 chr1:62921586 T/C cg19896129 chr1:63156450 NA 0.4 5.78 0.3 1.76e-8 Triglyceride levels; CRC cis rs67478160 0.643 rs2295141 chr14:104212949 T/C cg01849466 chr14:104193079 ZFYVE21 -0.49 -8.76 -0.43 1.04e-16 Schizophrenia; CRC cis rs2153535 0.623 rs2152346 chr6:8454652 A/G cg21535247 chr6:8435926 SLC35B3 0.5 7.5 0.38 5.81e-13 Motion sickness; CRC cis rs875971 0.528 rs801213 chr7:66014918 C/T cg11764359 chr7:65958608 NA -0.46 -5.81 -0.3 1.5e-8 Aortic root size; CRC cis rs1552244 0.882 rs13075842 chr3:10055813 A/C cg10729496 chr3:10149963 C3orf24 0.49 6.31 0.33 9.2e-10 Alzheimer's disease; CRC cis rs7666738 0.791 rs10010438 chr4:99022177 C/T cg17366294 chr4:99064904 C4orf37 0.43 7.29 0.37 2.28e-12 Colonoscopy-negative controls vs population controls; CRC cis rs6502050 0.842 rs9894129 chr17:80075700 A/G cg09264619 chr17:80180166 NA 0.36 5.92 0.31 8.22e-9 Life satisfaction; CRC trans rs6951245 0.572 rs112072378 chr7:1039400 C/T cg13565492 chr6:43139072 SRF -0.85 -6.18 -0.32 1.86e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs10078 0.571 rs890973 chr5:471494 T/C cg08916839 chr5:415575 AHRR 0.81 8.15 0.41 7.71e-15 Fat distribution (HIV); CRC cis rs10791323 0.569 rs10750541 chr11:133713189 A/C cg03690763 chr11:133734501 NA 0.35 5.73 0.3 2.25e-8 Childhood ear infection; CRC cis rs62400317 0.723 rs755 chr6:44795790 C/T cg18551225 chr6:44695536 NA -0.43 -5.75 -0.3 2.08e-8 Total body bone mineral density; CRC cis rs1707322 1.000 rs4073847 chr1:46463012 A/C cg03146154 chr1:46216737 IPP -0.49 -6.83 -0.35 4.11e-11 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs4713118 0.513 rs149954 chr6:28035246 G/A cg03623178 chr6:28175578 NA 0.78 11.53 0.54 4.63e-26 Parkinson's disease; CRC cis rs875971 0.964 rs1643388 chr7:65844562 T/C cg11764359 chr7:65958608 NA 0.61 9.95 0.48 1.41e-20 Aortic root size; CRC trans rs8002861 0.664 rs2218497 chr13:44428793 G/A cg12856521 chr11:46389249 DGKZ 0.44 7.2 0.37 4e-12 Leprosy; CRC cis rs9443645 0.869 rs2095724 chr6:79742101 C/T cg05283184 chr6:79620031 NA -0.62 -9.73 -0.47 7.88e-20 Intelligence (multi-trait analysis); CRC cis rs35538253 0.522 rs10492823 chr16:72018860 G/C cg08717414 chr16:71523259 ZNF19 -0.61 -5.68 -0.3 2.89e-8 Post bronchodilator FEV1; CRC cis rs6964587 0.692 rs7807490 chr7:91773359 A/G cg17063962 chr7:91808500 NA 0.61 9.86 0.48 2.84e-20 Breast cancer; CRC cis rs9894429 0.690 rs11869779 chr17:79570067 C/T cg18240062 chr17:79603768 NPLOC4 -0.66 -11.87 -0.55 2.74e-27 Eye color traits; CRC cis rs2224391 0.910 rs7752203 chr6:5260812 C/G cg09085698 chr6:5261316 LYRM4;FARS2 -0.43 -5.69 -0.3 2.83e-8 Height; CRC trans rs637571 0.584 rs7107912 chr11:65603252 G/A cg17712092 chr4:129076599 LARP1B -0.57 -8.86 -0.44 5.12e-17 Eosinophil percentage of white cells; CRC cis rs7799006 0.691 rs10447541 chr7:2301578 T/G cg08027265 chr7:2291960 NA -0.43 -6.98 -0.36 1.61e-11 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs7726839 0.540 rs11750321 chr5:599196 C/T cg17948913 chr5:572064 NA 0.51 5.88 0.31 1.01e-8 Obesity-related traits; CRC cis rs10791323 0.604 rs2723605 chr11:133711241 C/G cg03690763 chr11:133734501 NA -0.35 -5.87 -0.31 1.07e-8 Childhood ear infection; CRC cis rs6582630 0.555 rs2090785 chr12:38424342 G/A cg26384229 chr12:38710491 ALG10B 0.7 9.8 0.48 4.54e-20 Drug-induced liver injury (flucloxacillin); CRC cis rs6740322 0.948 rs6715072 chr2:43562230 C/T cg06169590 chr2:43455088 ZFP36L2;LOC100129726 -0.57 -7.23 -0.37 3.48e-12 Coronary artery disease; CRC cis rs4253772 0.530 rs715518 chr22:46754177 C/G cg24881330 chr22:46731750 TRMU 0.67 6.12 0.32 2.64e-9 LDL cholesterol;Cholesterol, total; CRC trans rs2303319 0.504 rs12474470 chr2:162535336 T/C cg14875682 chr5:52083620 ITGA1;PELO -0.76 -6.16 -0.32 2.13e-9 Cognitive function; CRC cis rs2243480 0.522 rs12698511 chr7:65474919 G/T cg18252515 chr7:66147081 NA -1.06 -9.28 -0.46 2.38e-18 Diabetic kidney disease; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg12934466 chr18:32820979 ZNF397 0.39 6.53 0.34 2.51e-10 Liver disease severity in Alagille syndrome; CRC cis rs7811142 0.830 rs6955367 chr7:99961194 A/G cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.58 8.0 0.4 2.22e-14 Platelet count; CRC cis rs11190604 0.767 rs4919459 chr10:102200371 C/T cg07080220 chr10:102295463 HIF1AN 0.49 6.0 0.31 5.34e-9 Palmitoleic acid (16:1n-7) levels; CRC cis rs2836950 0.565 rs2836930 chr21:40545656 A/G cg11644478 chr21:40555479 PSMG1 -0.52 -7.87 -0.4 5.16e-14 Menarche (age at onset); CRC cis rs10751667 0.621 rs11246345 chr11:934924 T/C cg01483505 chr11:975446 AP2A2 0.43 6.82 0.35 4.37e-11 Alzheimer's disease (late onset); CRC cis rs853679 0.517 rs9295761 chr6:28147987 A/G cg12273811 chr6:28175739 NA 0.74 9.32 0.46 1.76e-18 Depression; CRC cis rs8060686 0.920 rs1124324 chr16:67897487 C/T cg26727032 chr16:67993705 SLC12A4 -0.51 -6.27 -0.33 1.11e-9 HDL cholesterol;Metabolic syndrome; CRC trans rs6600671 0.934 rs12060031 chr1:121243450 A/G cg00646200 chr1:148855367 NA -0.34 -6.09 -0.32 3.22e-9 Hip geometry; CRC cis rs8031584 0.678 rs798086 chr15:31129211 C/G cg14829155 chr15:31115871 NA 0.62 9.5 0.46 4.55e-19 Huntington's disease progression; CRC cis rs7959452 0.532 rs2291005 chr12:69764388 A/G cg22834771 chr12:69754056 YEATS4 -0.53 -8.03 -0.4 1.79e-14 Blood protein levels; CRC cis rs4713118 0.539 rs200951 chr6:27835930 A/G cg15845792 chr6:28175446 NA 0.75 10.63 0.51 7.03e-23 Parkinson's disease; CRC cis rs12291225 0.585 rs4757250 chr11:14375683 C/A cg19336497 chr11:14380999 RRAS2 -0.53 -9.3 -0.46 2e-18 Sense of smell; CRC cis rs6831352 0.918 rs13127582 chr4:100058194 G/A cg12011299 chr4:100065546 ADH4 -0.48 -9.11 -0.45 8.42e-18 Alcohol dependence; CRC cis rs7546094 1.000 rs10745330 chr1:113083439 C/T cg22162597 chr1:113214053 CAPZA1 0.43 5.81 0.31 1.46e-8 Platelet distribution width; CRC cis rs7927771 1.000 rs7947730 chr11:47786184 C/T cg20307385 chr11:47447363 PSMC3 -0.5 -6.58 -0.34 1.83e-10 Subjective well-being; CRC cis rs11148252 0.532 rs9536185 chr13:53179801 G/A cg12458913 chr13:53173898 NA 0.9 16.36 0.67 1.98e-44 Lewy body disease; CRC cis rs2976388 0.609 rs2244152 chr8:143784885 C/A cg15511327 chr8:143859410 LYNX1 0.41 7.27 0.37 2.58e-12 Urinary tract infection frequency; CRC cis rs2153535 0.607 rs9502722 chr6:8541483 C/T cg21535247 chr6:8435926 SLC35B3 0.5 7.6 0.39 3.1400000000000003e-13 Motion sickness; CRC cis rs12497850 0.931 rs7636057 chr3:48992582 C/T cg07636037 chr3:49044803 WDR6 1.03 18.7 0.72 1.12e-53 Parkinson's disease; CRC cis rs10504229 0.728 rs72650861 chr8:58153273 T/C cg11062466 chr8:58055876 NA 0.45 6.11 0.32 2.74e-9 Developmental language disorder (linguistic errors); CRC cis rs868943 0.743 rs4628134 chr6:116360141 A/G cg15226275 chr6:116381976 FRK 0.28 6.76 0.35 6.26e-11 Total cholesterol levels; CRC cis rs600806 0.850 rs1343465 chr1:109937426 T/C cg23032129 chr1:109941072 SORT1 -0.28 -6.06 -0.32 3.68e-9 Intelligence (multi-trait analysis); CRC cis rs9296092 0.560 rs7765393 chr6:33525598 A/T cg13560919 chr6:33536144 NA -0.44 -6.28 -0.33 1.09e-9 Age at smoking initiation in chronic obstructive pulmonary disease; CRC cis rs2991971 1.000 rs2934859 chr1:46017836 C/T cg03123370 chr1:45965343 CCDC163P;MMACHC -0.39 -5.74 -0.3 2.11e-8 High light scatter reticulocyte count; CRC cis rs9467773 0.967 rs6941022 chr6:26553531 T/C cg09904177 chr6:26538194 HMGN4 0.85 14.85 0.63 1.61e-38 Intelligence (multi-trait analysis); CRC cis rs35110281 0.774 rs1003280 chr21:44997322 A/G cg01579765 chr21:45077557 HSF2BP -0.35 -6.67 -0.35 1.09e-10 Mean corpuscular volume; CRC cis rs7312933 0.510 rs1907705 chr12:42451122 T/A cg01256987 chr12:42539512 GXYLT1 -0.62 -10.98 -0.52 4.15e-24 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CRC cis rs1878931 0.696 rs35984213 chr16:3451030 G/A cg26668626 chr16:3451006 ZNF174;ZNF434 1.0 17.61 0.7 2.36e-49 Body mass index (adult); CRC cis rs853679 0.550 rs1237875 chr6:28173010 A/G cg23161317 chr6:28129485 ZNF389 -0.44 -5.76 -0.3 1.96e-8 Depression; CRC cis rs9372498 0.536 rs62663261 chr6:118900553 T/C cg18833306 chr6:118973337 C6orf204 0.44 5.76 0.3 1.9e-8 Diastolic blood pressure; CRC cis rs13315871 0.929 rs11715290 chr3:58298413 C/T cg20936604 chr3:58311152 NA -0.75 -7.05 -0.36 1.08e-11 Cholesterol, total; CRC cis rs17376456 0.877 rs55832164 chr5:93436579 C/T cg09848695 chr5:92956644 FAM172A;MIR2277 0.63 5.86 0.31 1.13e-8 Diabetic retinopathy; CRC cis rs924607 1.000 rs4045344 chr5:595870 G/T cg04221910 chr5:616842 CEP72 -0.42 -6.95 -0.36 1.96e-11 Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia; CRC cis rs56399783 0.901 rs17300022 chr7:2808517 C/T cg19731401 chr7:2775893 GNA12 -0.62 -6.85 -0.35 3.65e-11 Childhood ear infection; CRC cis rs3741404 0.665 rs12418535 chr11:63910980 A/G cg18225595 chr11:63971243 STIP1 0.65 10.61 0.5 8.49e-23 Platelet count; CRC cis rs4713118 0.824 rs2179095 chr6:27750858 A/G cg12172441 chr6:28176163 NA -0.54 -7.05 -0.36 1.03e-11 Parkinson's disease; CRC cis rs13315871 1.000 rs28417694 chr3:58373939 A/G cg20936604 chr3:58311152 NA -0.73 -6.69 -0.35 9.48e-11 Cholesterol, total; CRC cis rs977987 0.835 rs3851734 chr16:75371920 T/C cg03315344 chr16:75512273 CHST6 0.51 8.33 0.42 2.15e-15 Dupuytren's disease; CRC cis rs11105298 0.891 rs4842664 chr12:89938030 G/A cg08166232 chr12:89918718 WDR51B;GALNT4 -0.61 -7.5 -0.38 5.91e-13 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; CRC cis rs79839061 0.610 rs3736089 chr4:870118 G/A cg07828340 chr4:882639 GAK 1.12 10.93 0.52 6.49e-24 Intelligence (multi-trait analysis); CRC cis rs2839186 0.558 rs2968 chr21:47608580 C/T cg13126279 chr21:47581558 C21orf56 0.36 5.73 0.3 2.33e-8 Testicular germ cell tumor; CRC cis rs4843747 0.671 rs4075998 chr16:88106776 G/A cg07865391 chr16:88106882 BANP 0.46 6.05 0.32 3.86e-9 Menopause (age at onset); CRC cis rs6964587 1.000 rs6956596 chr7:91750107 T/G cg17063962 chr7:91808500 NA 0.78 12.5 0.57 1.32e-29 Breast cancer; CRC cis rs950776 0.518 rs11636131 chr15:78821606 C/T cg06917634 chr15:78832804 PSMA4 0.66 10.42 0.5 3.55e-22 Sudden cardiac arrest; CRC cis rs1215050 0.740 rs6854802 chr4:99065480 A/C cg05340658 chr4:99064831 C4orf37 0.49 7.33 0.37 1.78e-12 Waist-to-hip ratio adjusted for body mass index; CRC cis rs4604732 0.536 rs12074913 chr1:247631607 G/T cg12758973 chr1:247694275 LOC148824;OR2C3 0.37 5.66 0.3 3.3e-8 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CRC trans rs61931739 0.500 rs7484658 chr12:34515879 A/G cg26384229 chr12:38710491 ALG10B 0.61 9.1 0.45 8.55e-18 Morning vs. evening chronotype; CRC cis rs501120 1.000 rs554565 chr10:44755448 G/A cg09554077 chr10:44749378 NA 0.89 13.32 0.59 1.14e-32 Coronary artery disease;Coronary heart disease; CRC cis rs6502050 0.865 rs8073679 chr17:80155343 G/A cg13198984 chr17:80129470 CCDC57 0.48 8.46 0.42 9.02e-16 Life satisfaction; CRC cis rs1881797 1.000 rs12063141 chr1:247688343 G/A cg11166453 chr1:247681781 NA 0.45 7.14 0.37 6.11e-12 Acute lymphoblastic leukemia (childhood); CRC cis rs6502050 0.835 rs9674648 chr17:80096756 A/G cg11859384 chr17:80120422 CCDC57 -0.38 -6.13 -0.32 2.56e-9 Life satisfaction; CRC cis rs3760982 0.626 rs12463370 chr19:44292166 G/A cg11993925 chr19:44307056 LYPD5 0.47 7.73 0.39 1.3e-13 Breast cancer (estrogen-receptor negative);Breast cancer; CRC cis rs9372498 0.536 rs9320656 chr6:118894468 A/G cg22561889 chr6:118971681 C6orf204 -0.51 -6.65 -0.34 1.19e-10 Diastolic blood pressure; CRC cis rs3820068 0.581 rs12385690 chr1:15932932 A/T cg27534772 chr1:16042836 PLEKHM2 0.55 10.86 0.51 1.12e-23 Systolic blood pressure; CRC cis rs3796352 1.000 rs11710292 chr3:53117798 T/C cg07884673 chr3:53033167 SFMBT1 0.76 6.17 0.32 1.98e-9 Immune reponse to smallpox (secreted IL-2); CRC cis rs1129187 0.755 rs2274517 chr6:42932715 A/G cg21280719 chr6:42927975 GNMT 0.45 10.23 0.49 1.66e-21 Alzheimer's disease in APOE e4+ carriers; CRC cis rs1862618 0.853 rs190414 chr5:56116772 C/A cg18230493 chr5:56204884 C5orf35 -0.7 -9.1 -0.45 9.19e-18 Initial pursuit acceleration; CRC trans rs2099149 0.748 rs1320925 chr12:30461980 A/G cg15529703 chr5:17187054 LOC285696 -0.47 -6.02 -0.31 4.66e-9 Cannabis use; CRC cis rs6570726 0.764 rs376257 chr6:145862949 G/A cg05347473 chr6:146136440 FBXO30 0.39 5.95 0.31 6.94e-9 Lobe attachment (rater-scored or self-reported); CRC trans rs11722228 0.549 rs62288521 chr4:10099772 G/A cg26043149 chr18:55253948 FECH 1.14 17.5 0.69 6.1e-49 Gout;Urate levels;Serum uric acid levels; CRC cis rs1046896 1.000 rs1046896 chr17:80685533 A/G cg08200770 chr17:80723486 TBCD 0.42 7.27 0.37 2.65e-12 Glycated hemoglobin levels; CRC cis rs4566357 0.595 rs10201538 chr2:227914449 A/G cg11843606 chr2:227700838 RHBDD1 -0.45 -7.02 -0.36 1.28e-11 Coronary artery disease; CRC cis rs2949837 0.655 rs11977526 chr7:46008110 G/A cg21268650 chr7:45961089 IGFBP3 0.46 7.57 0.39 3.78e-13 Sitting height ratio; CRC cis rs1448094 0.512 rs6539928 chr12:86244920 G/A cg18827107 chr12:86230957 RASSF9 -0.46 -7.53 -0.38 4.82e-13 Major depressive disorder; CRC cis rs1348850 0.914 rs4893938 chr2:178250095 T/C cg22681709 chr2:178499509 PDE11A -0.37 -6.91 -0.36 2.53e-11 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs72945132 0.562 rs7951959 chr11:70234272 A/G cg14191688 chr11:70257035 CTTN 0.55 7.72 0.39 1.44e-13 Coronary artery disease; CRC trans rs2303319 0.504 rs1006427 chr2:162592328 T/C cg20024234 chr21:43431083 ZNF295 -0.66 -5.99 -0.31 5.57e-9 Cognitive function; CRC cis rs7945705 0.935 rs1883098 chr11:8890594 G/A cg21881798 chr11:8931708 C11orf17;ST5 -0.75 -12.91 -0.58 3.96e-31 Hemoglobin concentration; CRC trans rs7647973 0.626 rs9824435 chr3:49674343 A/G cg21665057 chr3:196295764 WDR53;FBXO45 0.62 6.29 0.33 9.83e-10 Menarche (age at onset); CRC cis rs3733585 0.699 rs7676733 chr4:9966956 G/A cg00071950 chr4:10020882 SLC2A9 -0.55 -9.72 -0.47 8.53e-20 Cleft plate (environmental tobacco smoke interaction); CRC cis rs6502050 0.731 rs11867299 chr17:80088675 C/A cg25804541 chr17:80189381 SLC16A3 -0.3 -5.84 -0.31 1.24e-8 Life satisfaction; CRC cis rs34526934 0.608 rs7606110 chr2:177028551 T/C cg10305451 chr2:177043427 NA -0.53 -6.82 -0.35 4.28e-11 Obstructive sleep apnea trait (apnea hypopnea index); CRC cis rs66887589 0.777 rs1814815 chr4:120258091 C/T cg09307838 chr4:120376055 NA 0.56 8.74 0.43 1.17e-16 Diastolic blood pressure; CRC cis rs2274273 0.588 rs9323285 chr14:55863829 A/C cg10130446 chr14:55658398 DLGAP5 0.42 5.83 0.31 1.33e-8 Protein biomarker; CRC cis rs4731207 0.689 rs1481341 chr7:124567123 C/T cg23710748 chr7:124431027 NA -0.38 -6.03 -0.32 4.52e-9 Cutaneous malignant melanoma; CRC cis rs1348850 0.872 rs13004955 chr2:178398923 A/T cg22681709 chr2:178499509 PDE11A 0.37 6.73 0.35 7.45e-11 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs6860806 0.507 rs582490 chr5:131710095 G/A cg22638593 chr5:131593259 PDLIM4 -0.38 -6.32 -0.33 8.61e-10 Breast cancer; CRC cis rs7809950 1.000 rs10273733 chr7:107258121 A/G cg23024343 chr7:107201750 COG5 0.57 8.0 0.4 2.17e-14 Coronary artery disease; CRC cis rs1707322 0.721 rs10890337 chr1:46124527 C/T cg03146154 chr1:46216737 IPP 0.67 9.75 0.47 6.98e-20 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs7731657 0.537 rs3981333 chr5:130375045 A/T cg08523029 chr5:130500466 HINT1 -0.44 -5.86 -0.31 1.15e-8 Fasting plasma glucose; CRC cis rs225245 0.817 rs1476553 chr17:33994566 C/T cg05299278 chr17:33885742 SLFN14 0.48 7.86 0.4 5.43e-14 Reticulocyte count;Reticulocyte fraction of red cells;High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells; CRC cis rs6952808 0.723 rs60432611 chr7:2029629 G/C cg21782813 chr7:2030301 MAD1L1 0.54 9.44 0.46 7.29e-19 Bipolar disorder and schizophrenia; CRC cis rs11105298 0.891 rs11105316 chr12:89925200 T/G cg00757033 chr12:89920650 WDR51B 0.38 6.23 0.32 1.4e-9 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; CRC cis rs7333181 1.000 rs7333181 chr13:112221297 G/A cg27543320 chr13:112200689 NA 0.5 6.2 0.32 1.69e-9 Menopause (age at onset); CRC trans rs4378999 0.660 rs9824444 chr3:50782765 C/T cg12383621 chr7:7735611 RPA3 -0.48 -6.05 -0.32 3.92e-9 Waist circumference adjusted for BMI in non-smokers;Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction); CRC cis rs1865760 0.532 rs2794719 chr6:26088890 T/G cg17691542 chr6:26056736 HIST1H1C 0.55 8.3 0.42 2.82e-15 Height; CRC cis rs11122272 0.766 rs2790870 chr1:231543823 A/G cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.63 -9.76 -0.47 6.15e-20 Hemoglobin concentration; CRC cis rs7811142 1.000 rs76913697 chr7:100002772 A/G cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.98 13.5 0.6 2.45e-33 Platelet count; CRC cis rs875971 0.619 rs10278371 chr7:66051540 C/A cg18876405 chr7:65276391 NA -0.62 -11.21 -0.53 6.54e-25 Aortic root size; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg27563952 chr1:182557982 NA 0.44 6.3 0.33 9.76e-10 Intelligence (multi-trait analysis); CRC cis rs9811920 0.609 rs4244711 chr3:99657205 A/G cg07805332 chr3:99536008 MIR548G;C3orf26 0.51 7.68 0.39 1.84e-13 Axial length; CRC cis rs10479542 0.583 rs4131080 chr5:179044292 G/A cg09060608 chr5:178986726 RUFY1 0.49 7.84 0.4 6.43e-14 Lung cancer; CRC trans rs7615952 0.512 rs11921452 chr3:125359750 A/G cg08546805 chr12:8549446 NA -0.43 -6.55 -0.34 2.26e-10 Blood pressure (smoking interaction); CRC cis rs1005277 0.579 rs2023351 chr10:38378814 A/G cg25517755 chr10:38738941 LOC399744 -0.44 -6.39 -0.33 5.65e-10 Extrinsic epigenetic age acceleration; CRC cis rs7833790 0.926 rs72686467 chr8:82758929 T/G cg17211192 chr8:82754475 SNX16 0.56 6.79 0.35 5.1e-11 Diastolic blood pressure; CRC trans rs3008870 0.583 rs11208978 chr1:67442210 C/T cg01448155 chr10:3564782 NA 0.52 6.22 0.32 1.5e-9 Lymphocyte percentage of white cells; CRC cis rs9287719 0.967 rs1541574 chr2:10773508 A/T cg00105475 chr2:10696890 NA 0.45 7.19 0.37 4.48e-12 Prostate cancer; CRC cis rs4654899 0.727 rs11805169 chr1:21156862 A/T cg02927042 chr1:21476669 EIF4G3 0.46 7.32 0.37 1.93e-12 Superior frontal gyrus grey matter volume; CRC cis rs2274273 0.934 rs2341621 chr14:55726425 C/T cg23234261 chr14:55582407 NA -0.29 -5.67 -0.3 3.12e-8 Protein biomarker; CRC cis rs1048238 0.506 rs10927867 chr1:16177285 A/G cg21385522 chr1:16154831 NA 0.63 9.09 0.45 9.37e-18 Systolic blood pressure; CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg09273779 chr9:35605990 TESK1 -0.51 -6.25 -0.33 1.27e-9 Diisocyanate-induced asthma; CRC cis rs6500602 0.964 rs62039173 chr16:4463846 G/A cg08645402 chr16:4508243 NA 0.58 9.52 0.46 3.95e-19 Schizophrenia; CRC cis rs12190007 0.547 rs2981944 chr6:169801753 T/G cg15038512 chr6:170123185 PHF10 -0.38 -5.93 -0.31 7.66e-9 Obesity-related traits; CRC cis rs11758351 0.660 rs11755943 chr6:26211368 A/G cg22723502 chr6:26240528 HIST1H4F -0.36 -6.04 -0.32 4.15e-9 Gout;Renal underexcretion gout; CRC cis rs9926296 0.585 rs8058009 chr16:89856439 G/C cg02875869 chr16:89901417 SPIRE2 -1.22 -17.09 -0.69 2.49e-47 Vitiligo; CRC cis rs2404602 0.692 rs35395069 chr15:76986334 C/T cg23625390 chr15:77176239 SCAPER 0.5 7.29 0.37 2.4e-12 Blood metabolite levels; CRC cis rs4665809 0.878 rs4665826 chr2:26367503 A/T cg26119090 chr2:26468346 HADHA;HADHB 0.75 9.11 0.45 8.14e-18 Gut microbiome composition (summer); CRC cis rs2404602 0.647 rs34103231 chr15:76912690 A/G cg23625390 chr15:77176239 SCAPER -0.87 -13.33 -0.59 1.04e-32 Blood metabolite levels; CRC cis rs1448094 0.512 rs12313775 chr12:86241197 G/A cg18827107 chr12:86230957 RASSF9 -0.45 -7.42 -0.38 9.97e-13 Major depressive disorder; CRC cis rs1568889 1.000 rs12803655 chr11:28060785 G/A cg06544937 chr11:28130018 METT5D1;KIF18A 0.78 11.27 0.53 3.9e-25 Bipolar disorder; CRC cis rs2032447 0.901 rs1540276 chr6:26028819 T/G cg26028573 chr6:26043587 HIST1H2BB 0.5 7.34 0.38 1.68e-12 Intelligence (multi-trait analysis); CRC cis rs10982256 0.711 rs10817635 chr9:117288169 A/C cg13636371 chr9:117264095 DFNB31 -0.33 -6.09 -0.32 3.21e-9 Bipolar disorder; CRC cis rs11792861 0.926 rs56899598 chr9:111867271 A/G cg05043794 chr9:111880884 C9orf5 -0.36 -6.55 -0.34 2.2e-10 Menarche (age at onset); CRC cis rs870825 0.616 rs4264873 chr4:185624336 C/T cg04058563 chr4:185651563 MLF1IP 0.72 9.38 0.46 1.12e-18 Blood protein levels; CRC cis rs754466 0.958 rs58916802 chr10:79695870 G/A cg17075019 chr10:79541650 NA -0.72 -9.91 -0.48 1.94e-20 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs3806843 0.576 rs246063 chr5:140324492 T/A cg19875535 chr5:140030758 IK 0.39 6.02 0.31 4.67e-9 Depressive symptoms (multi-trait analysis); CRC cis rs853679 0.517 rs3757185 chr6:28107776 T/A cg12172441 chr6:28176163 NA 0.62 7.4 0.38 1.17e-12 Depression; CRC cis rs2115630 0.967 rs8028490 chr15:85277888 G/A cg11189052 chr15:85197271 WDR73 -0.61 -9.96 -0.48 1.33e-20 P wave terminal force; CRC cis rs55665837 1.000 rs12283797 chr11:14442262 C/G cg19336497 chr11:14380999 RRAS2 -0.39 -6.61 -0.34 1.58e-10 Vitamin D levels; CRC cis rs875971 0.798 rs12698522 chr7:65967341 T/C cg18876405 chr7:65276391 NA 0.51 8.18 0.41 6.35e-15 Aortic root size; CRC trans rs28735056 0.592 rs10853392 chr18:77708781 A/G cg05926928 chr17:57297772 GDPD1 -0.41 -6.26 -0.33 1.18e-9 Schizophrenia; CRC cis rs10504073 0.609 rs17644494 chr8:50019679 T/C cg00325661 chr8:49890786 NA 0.45 8.11 0.41 1.03e-14 Blood metabolite ratios; CRC cis rs2797160 1.000 rs1739380 chr6:126012858 T/C cg05901451 chr6:126070800 HEY2 0.4 6.12 0.32 2.71e-9 Endometrial cancer; CRC cis rs427394 0.582 rs4701751 chr5:6704137 C/T cg15145174 chr5:6755386 POLS -0.47 -6.57 -0.34 1.97e-10 Menopause (age at onset); CRC cis rs7909074 1.000 rs10736831 chr10:45402311 G/A cg05187965 chr10:45406764 TMEM72 -0.37 -8.32 -0.42 2.45e-15 Mean corpuscular volume; CRC cis rs10193935 0.792 rs7559001 chr2:42474301 C/T cg27598129 chr2:42591480 NA -0.5 -6.21 -0.32 1.64e-9 Colonoscopy-negative controls vs population controls; CRC cis rs780096 0.506 rs2950834 chr2:27627366 G/A cg24768116 chr2:27665128 KRTCAP3 -0.35 -7.96 -0.4 2.84e-14 Total body bone mineral density; CRC cis rs12497850 0.931 rs6446253 chr3:48911443 C/T cg20833759 chr3:49053208 WDR6;DALRD3 0.51 8.74 0.43 1.19e-16 Parkinson's disease; CRC trans rs11885103 0.543 rs2685245 chr2:554536 C/G cg12228919 chr15:44955936 SPG11 -0.48 -7.28 -0.37 2.46e-12 Heschl's gyrus morphology; CRC cis rs9311474 0.508 rs7652191 chr3:52610415 T/C cg15147215 chr3:52552868 STAB1 -0.63 -10.98 -0.52 4.02e-24 Electroencephalogram traits; CRC cis rs9916302 0.904 rs4795384 chr17:37716771 C/G cg15445000 chr17:37608096 MED1 0.4 8.69 0.43 1.7e-16 Glomerular filtration rate (creatinine); CRC cis rs694739 0.726 rs516124 chr11:64128423 G/T cg02228329 chr11:64053129 BAD;GPR137 0.5 7.09 0.36 8.37e-12 Alopecia areata;Crohn's disease;Psoriasis vulgaris; CRC cis rs1401999 1.000 rs13317532 chr3:183641669 G/C cg20387954 chr3:183756860 HTR3D 0.44 7.43 0.38 9.38e-13 Anterior chamber depth; CRC cis rs6500602 0.893 rs8061742 chr16:4489436 T/C cg14951292 chr16:4525986 HMOX2;NMRAL1 0.58 8.29 0.42 2.84e-15 Schizophrenia; CRC cis rs738322 0.870 rs2277844 chr22:38577515 G/A cg25457927 chr22:38595422 NA 0.4 8.52 0.43 5.74e-16 Cutaneous nevi; CRC cis rs11168351 0.833 rs6580652 chr12:48447105 C/A cg00601486 chr12:48723148 H1FNT -0.35 -6.77 -0.35 5.96e-11 Bipolar disorder and schizophrenia; CRC cis rs1005277 0.579 rs2474599 chr10:38438939 A/G cg25427524 chr10:38739819 LOC399744 -0.75 -13.32 -0.59 1.17e-32 Extrinsic epigenetic age acceleration; CRC cis rs2304069 0.545 rs11167492 chr5:149403101 G/A cg12661370 chr5:149340060 SLC26A2 0.44 6.36 0.33 6.8e-10 HIV-1 control; CRC cis rs28386778 0.799 rs2665836 chr17:61898135 C/A cg07362569 chr17:61921086 SMARCD2 0.37 5.71 0.3 2.57e-8 Prudent dietary pattern; CRC cis rs7618501 1.000 rs3749241 chr3:49744392 A/G cg24308560 chr3:49941425 MST1R 0.44 6.86 0.35 3.46e-11 Intelligence (multi-trait analysis); CRC cis rs7666738 0.830 rs1593569 chr4:99017485 C/G cg17366294 chr4:99064904 C4orf37 0.43 7.15 0.37 5.59e-12 Colonoscopy-negative controls vs population controls; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg09936889 chr8:102135665 NA 0.45 6.35 0.33 7.26e-10 Response to antipsychotic treatment; CRC cis rs798554 0.797 rs798486 chr7:2803037 A/G cg14863265 chr7:2801509 GNA12 -0.41 -5.66 -0.3 3.36e-8 Height; CRC cis rs7727544 0.716 rs4705928 chr5:131578637 A/G cg02033258 chr5:131593261 PDLIM4 -0.38 -7.13 -0.37 6.22e-12 Blood metabolite levels; CRC cis rs4919694 1.000 rs12258551 chr10:104767892 C/G cg04362960 chr10:104952993 NT5C2 1.17 10.93 0.52 6.24e-24 Arsenic metabolism; CRC cis rs4733781 0.509 rs12550365 chr8:131136046 A/T cg26053073 chr8:131455383 NA -0.34 -5.63 -0.3 3.92e-8 Tuberculosis; CRC cis rs11764590 0.666 rs3996325 chr7:2053747 T/C cg21155852 chr7:2048760 MAD1L1 -0.39 -5.7 -0.3 2.65e-8 Neuroticism; CRC cis rs7666738 0.861 rs5010991 chr4:98972179 A/G cg05340658 chr4:99064831 C4orf37 0.59 9.2 0.45 4.11e-18 Colonoscopy-negative controls vs population controls; CRC cis rs7309 0.810 rs11684253 chr2:162034536 G/T cg21518248 chr2:162101506 NA 0.45 6.64 0.34 1.26e-10 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Educational attainment; CRC cis rs11758351 0.715 rs75390741 chr6:26209784 A/T cg10723962 chr6:26240782 HIST1H4F -0.39 -6.26 -0.33 1.23e-9 Gout;Renal underexcretion gout; CRC trans rs1814175 0.616 rs1851848 chr11:49992254 G/C cg03929089 chr4:120376271 NA -0.91 -15.94 -0.66 8.84e-43 Height; CRC cis rs6499255 0.951 rs16958970 chr16:69627793 G/A cg05250797 chr16:70222502 NA 0.4 5.65 0.3 3.52e-8 IgE levels; CRC trans rs2303319 0.504 rs12465645 chr2:162437639 A/G cg09481857 chr22:21368659 P2RX6;MGC16703 -0.65 -6.0 -0.31 5.13e-9 Cognitive function; CRC cis rs1153858 1.000 rs60476496 chr15:45713801 C/T cg10760299 chr15:45669010 GATM 0.51 7.81 0.4 7.68e-14 Homoarginine levels; CRC cis rs6502050 0.734 rs9674631 chr17:80096525 A/G cg22110888 chr17:80059540 CCDC57 0.41 6.5 0.34 2.97e-10 Life satisfaction; CRC cis rs6772849 0.830 rs4857917 chr3:128376178 C/T cg08795948 chr3:128337044 NA 0.35 5.99 0.31 5.51e-9 Monocyte percentage of white cells;Monocyte count; CRC cis rs17345786 1.000 rs997739 chr3:101313940 A/G cg12386194 chr3:101231763 SENP7 0.55 7.11 0.36 7.26e-12 Colonoscopy-negative controls vs population controls; CRC cis rs524281 0.861 rs6591207 chr11:65949674 A/T cg16950941 chr11:66035639 RAB1B -0.61 -7.47 -0.38 7.15e-13 Electroencephalogram traits; CRC cis rs13202913 0.733 rs13215869 chr6:151803659 G/A cg10883421 chr6:151773342 RMND1;C6orf211 0.62 6.89 0.36 2.77e-11 Epstein-Barr virus copy number in lymphoblastoid cell lines; CRC cis rs10193935 0.582 rs13394853 chr2:42630900 T/C cg27598129 chr2:42591480 NA -0.67 -7.83 -0.4 6.65e-14 Colonoscopy-negative controls vs population controls; CRC trans rs2228479 0.850 rs11648689 chr16:89806732 G/A cg24644049 chr4:85504048 CDS1 0.9 7.41 0.38 1.05e-12 Skin colour saturation; CRC cis rs7618915 0.501 rs13079063 chr3:52744460 A/G cg18099408 chr3:52552593 STAB1 -0.46 -7.73 -0.39 1.36e-13 Bipolar disorder; CRC cis rs651907 0.535 rs12633089 chr3:101528763 C/T cg12386194 chr3:101231763 SENP7 0.51 7.36 0.38 1.51e-12 Colorectal cancer; CRC trans rs11098499 0.535 rs10005542 chr4:120268302 T/C cg25214090 chr10:38739885 LOC399744 0.54 8.51 0.42 6.07e-16 Corneal astigmatism; CRC trans rs11148252 0.846 rs1056335 chr13:52989863 C/T cg18335740 chr13:41363409 SLC25A15 0.54 8.26 0.41 3.51e-15 Lewy body disease; CRC cis rs7772486 0.875 rs9403763 chr6:146357655 A/G cg23711669 chr6:146136114 FBXO30 0.68 11.85 0.55 3.34e-27 Lobe attachment (rater-scored or self-reported); CRC cis rs6912958 0.712 rs6454638 chr6:88329427 C/T cg12350822 chr6:88032061 C6orf162;GJB7 0.33 6.26 0.33 1.23e-9 Monocyte percentage of white cells; CRC cis rs1552244 1.000 rs68067759 chr3:10150535 T/C cg02579736 chr3:10068473 FANCD2;CIDECP 1.03 13.85 0.61 1.06e-34 Alzheimer's disease; CRC trans rs2228479 0.850 rs62054601 chr16:89811751 C/G cg24644049 chr4:85504048 CDS1 0.9 7.46 0.38 7.69e-13 Skin colour saturation; CRC cis rs12900413 0.603 rs7177841 chr15:90302117 C/A cg24249390 chr15:90295951 MESP1 -0.61 -9.38 -0.46 1.15e-18 Coronary artery aneurysm in Kawasaki disease; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg26190281 chr1:36235743 CLSPN 0.41 6.05 0.32 3.96e-9 Intelligence (multi-trait analysis); CRC cis rs6089584 0.888 rs6061982 chr20:60620673 C/T cg18761221 chr20:60518478 NA 0.45 7.18 0.37 4.62e-12 Body mass index; CRC cis rs60871478 0.947 rs62432239 chr7:794576 C/T cg13844804 chr7:814759 HEATR2 0.64 8.29 0.42 2.88e-15 Cerebrospinal P-tau181p levels; CRC cis rs344364 0.511 rs12596510 chr16:1949480 G/A cg03013636 chr16:1946785 NA 0.58 7.08 0.36 8.69e-12 Glomerular filtration rate in chronic kidney disease; CRC cis rs10504229 0.610 rs7840469 chr8:58146992 C/T cg21724239 chr8:58056113 NA 0.42 6.13 0.32 2.48e-9 Developmental language disorder (linguistic errors); CRC cis rs910316 0.874 rs61980828 chr14:75630378 G/A cg03030879 chr14:75389066 RPS6KL1 0.47 7.22 0.37 3.69e-12 Height; CRC cis rs12142240 0.698 rs1057535 chr1:46815898 T/C cg14993813 chr1:46806288 NSUN4 -0.5 -6.4 -0.33 5.38e-10 Menopause (age at onset); CRC cis rs2213920 0.679 rs6478168 chr9:118225951 A/T cg13918206 chr9:118159781 DEC1 0.63 5.99 0.31 5.5e-9 Docetaxel-induced peripheral neuropathy in metastatic castrate-resistant prostate cancer; CRC cis rs3924048 0.574 rs11121928 chr1:12615888 C/G cg00291366 chr1:12616550 NA 0.58 10.77 0.51 2.35e-23 Optic cup area; CRC cis rs992157 0.835 rs2292555 chr2:219146882 G/C cg20019365 chr2:219134978 PNKD;AAMP -0.39 -5.62 -0.3 3.98e-8 Colorectal cancer; CRC cis rs4774899 0.752 rs2962991 chr15:57348776 A/G cg08128148 chr15:57256372 TCF12 -0.39 -5.66 -0.3 3.33e-8 Urinary tract infection frequency; CRC cis rs10760123 1 rs10760123 chr9:123650534 T/G cg14255062 chr9:123606675 PSMD5;LOC253039 0.43 6.25 0.33 1.28e-9 Allergic disease (asthma, hay fever or eczema); CRC trans rs11098499 0.675 rs11098534 chr4:120556772 T/G cg25214090 chr10:38739885 LOC399744 0.55 8.58 0.43 3.87e-16 Corneal astigmatism; CRC cis rs9303542 0.559 rs12938390 chr17:46614722 T/C cg04904318 chr17:46607828 HOXB1 -0.53 -6.17 -0.32 2.02e-9 Ovarian cancer;Epithelial ovarian cancer; CRC trans rs7395662 0.963 rs6485889 chr11:48608785 C/T cg21153622 chr11:89784906 NA -0.45 -7.21 -0.37 3.98e-12 HDL cholesterol; CRC cis rs457287 0.772 rs10974804 chr9:4827719 A/T cg14182974 chr9:4791918 RCL1 0.45 6.28 0.33 1.05e-9 Platelet count; CRC cis rs11971779 0.584 rs17613864 chr7:139095587 C/T cg07862535 chr7:139043722 LUC7L2 0.57 7.32 0.37 1.92e-12 Diisocyanate-induced asthma; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg21335187 chr2:88990994 RPIA 0.49 6.87 0.35 3.12e-11 Response to antipsychotic treatment; CRC cis rs10883723 0.810 rs10748823 chr10:104274465 C/G cg04362960 chr10:104952993 NT5C2 -0.42 -5.94 -0.31 7.28e-9 Allergic disease (asthma, hay fever or eczema); CRC cis rs7843479 1.000 rs7821592 chr8:21811530 C/G cg17168535 chr8:21777572 XPO7 0.55 8.78 0.44 8.95e-17 Mean corpuscular volume; CRC cis rs9487051 0.872 rs6924815 chr6:109612344 A/G cg21918786 chr6:109611834 NA -0.44 -8.12 -0.41 9.71e-15 Reticulocyte fraction of red cells; CRC cis rs2073300 0.609 rs6137937 chr20:23385419 G/A cg12062639 chr20:23401060 NAPB 0.76 6.64 0.34 1.3e-10 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs1218582 0.688 rs58629129 chr1:154910930 T/C cg09359103 chr1:154839909 KCNN3 -0.72 -11.24 -0.53 5.05e-25 Prostate cancer; CRC cis rs6743376 0.556 rs2515399 chr2:113819451 G/T cg24553058 chr2:113831203 IL1F10 0.43 6.96 0.36 1.81e-11 Inflammatory biomarkers; CRC cis rs832540 0.898 rs252890 chr5:56226410 T/C cg24531977 chr5:56204891 C5orf35 -0.49 -7.57 -0.38 3.9e-13 Coronary artery disease; CRC cis rs7552404 0.961 rs1767458 chr1:76219155 A/G cg22875332 chr1:76189707 ACADM 0.69 10.56 0.5 1.2e-22 Blood metabolite levels;Acylcarnitine levels; CRC cis rs4290604 0.748 rs62183337 chr2:237962838 C/T cg23555395 chr2:238036564 NA 0.62 6.09 0.32 3.12e-9 Asthma; CRC cis rs6831352 0.918 rs2602896 chr4:100046207 C/T cg13256891 chr4:100009986 ADH5 -0.66 -8.79 -0.44 8.56e-17 Alcohol dependence; CRC cis rs4689592 0.554 rs3951346 chr4:7073321 C/T cg26116260 chr4:7069785 GRPEL1 0.96 15.46 0.65 6.81e-41 Monocyte percentage of white cells; CRC cis rs1003719 0.667 rs73201942 chr21:38475164 G/C cg10648535 chr21:38446584 PIGP;TTC3 0.45 6.1 0.32 2.92e-9 Eye color traits; CRC cis rs1005277 0.579 rs1740737 chr10:38499365 G/T cg00409905 chr10:38381863 ZNF37A -0.64 -10.52 -0.5 1.66e-22 Extrinsic epigenetic age acceleration; CRC cis rs4665809 0.590 rs34728554 chr2:26481959 C/G cg26119090 chr2:26468346 HADHA;HADHB 1.06 15.53 0.65 3.62e-41 Gut microbiome composition (summer); CRC cis rs2072510 1.000 rs2540492 chr12:96417659 C/T cg09636302 chr12:96389483 HAL -0.37 -5.66 -0.3 3.25e-8 Metabolite levels (small molecules and protein measures); CRC cis rs6951245 0.872 rs77434655 chr7:1098405 G/A cg20603222 chr7:1096387 C7orf50;GPR146 -0.72 -8.66 -0.43 2.19e-16 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs950169 0.959 rs66801143 chr15:84736657 C/T cg24253500 chr15:84953950 NA 0.37 6.18 0.32 1.92e-9 Schizophrenia; CRC cis rs4819852 1.000 rs7285377 chr22:19987202 G/T cg07821417 chr22:19972146 ARVCF 0.45 5.82 0.31 1.39e-8 Pulse pressure; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg23268892 chr14:102553431 HSP90AA1 0.39 6.03 0.32 4.48e-9 Liver disease severity in Alagille syndrome; CRC trans rs2727020 0.595 rs7924311 chr11:49507573 G/A cg03929089 chr4:120376271 NA -0.92 -17.44 -0.69 1.05e-48 Coronary artery disease; CRC cis rs4665809 1.000 rs11126364 chr2:26314515 A/G cg04944784 chr2:26401820 FAM59B -0.6 -7.77 -0.39 1.01e-13 Gut microbiome composition (summer); CRC cis rs7208859 0.623 rs216439 chr17:28927884 T/C cg19761014 chr17:28927070 LRRC37B2 0.56 5.68 0.3 2.94e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs10128264 0.934 rs1250589 chr10:80980304 C/G cg20744163 chr10:80999841 ZMIZ1 -0.43 -7.39 -0.38 1.19e-12 Response to methotrexate in juvenile idiopathic arthritis; CRC cis rs1559088 0.600 rs7259117 chr19:33550113 G/T cg27124370 chr19:33622961 WDR88 0.47 6.96 0.36 1.87e-11 Bone ultrasound measurement (broadband ultrasound attenuation); CRC cis rs6502050 0.835 rs7406529 chr17:80080877 C/T cg02741985 chr17:80059408 CCDC57 -0.44 -7.18 -0.37 4.75e-12 Life satisfaction; CRC trans rs7615952 0.799 rs13315434 chr3:125641394 T/G cg00769240 chr8:12517080 NA -0.56 -6.78 -0.35 5.57e-11 Blood pressure (smoking interaction); CRC cis rs9318086 0.648 rs4067969 chr13:24469120 G/A cg25267304 chr13:24462978 PCOTH;MIPEP 0.67 10.76 0.51 2.55e-23 Myopia (pathological); CRC trans rs1814175 0.618 rs1851843 chr11:50021846 T/C cg15704280 chr7:45808275 SEPT13 -0.92 -16.92 -0.68 1.2e-46 Height; CRC cis rs8180040 0.593 rs4018905 chr3:47138170 A/G cg10298567 chr3:47292165 KIF9 -0.4 -6.24 -0.33 1.37e-9 Colorectal cancer; CRC cis rs921968 0.541 rs620596 chr2:219462419 G/A cg02176678 chr2:219576539 TTLL4 0.54 8.64 0.43 2.55e-16 Mean corpuscular hemoglobin concentration; CRC cis rs896854 0.684 rs10099941 chr8:95987008 C/T cg23172400 chr8:95962367 TP53INP1 -0.46 -7.81 -0.4 7.78e-14 Type 2 diabetes; CRC cis rs1799949 0.965 rs33925201 chr17:41280682 A/G cg25072359 chr17:41440525 NA 0.46 6.94 0.36 2.14e-11 Menopause (age at onset); CRC cis rs3849570 0.961 rs11915042 chr3:81834060 G/A cg07356753 chr3:81810745 GBE1 -0.73 -11.17 -0.52 8.96e-25 Waist circumference;Body mass index; CRC cis rs7412746 0.611 rs4970985 chr1:150887442 C/T cg15448220 chr1:150897856 SETDB1 -0.45 -6.56 -0.34 2.1e-10 Melanoma; CRC cis rs11190604 1.000 rs2489051 chr10:102351785 C/T cg16342193 chr10:102329863 NA 0.35 5.71 0.3 2.47e-8 Palmitoleic acid (16:1n-7) levels; CRC trans rs2797160 0.904 rs2326292 chr6:125999674 G/A cg05039488 chr6:79577232 IRAK1BP1 -0.58 -8.72 -0.43 1.4e-16 Endometrial cancer; CRC cis rs10256972 0.684 rs4724039 chr7:1111633 A/G cg04025307 chr7:1156635 C7orf50 0.55 8.53 0.43 5.5e-16 Longevity;Endometriosis; CRC cis rs8177253 0.931 rs8177256 chr3:133480276 G/T cg16262614 chr3:133464971 TF 0.33 5.91 0.31 8.53e-9 Iron status biomarkers; CRC cis rs17826219 0.636 rs12946563 chr17:29103166 C/G cg13385521 chr17:29058706 SUZ12P 0.74 8.37 0.42 1.73e-15 Body mass index; CRC cis rs589448 0.535 rs12423794 chr12:69713018 G/A cg22834771 chr12:69754056 YEATS4 -0.42 -5.88 -0.31 9.81e-9 Cerebrospinal fluid biomarker levels; CRC cis rs853679 0.517 rs12332979 chr6:28141548 T/G cg12273811 chr6:28175739 NA 0.72 9.03 0.45 1.47e-17 Depression; CRC cis rs1707322 0.506 rs2991983 chr1:46079391 T/C cg03146154 chr1:46216737 IPP -0.68 -9.66 -0.47 1.38e-19 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs10080237 0.564 rs2490230 chr6:80812464 G/A cg08355045 chr6:80787529 NA 0.4 6.81 0.35 4.61e-11 Waist circumference adjusted for body mass index;Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction);Waist circumference adjusted for BMI in active individuals; CRC cis rs57221529 0.713 rs12522724 chr5:590742 T/C cg14541582 chr5:601475 NA -0.36 -7.11 -0.36 7.3e-12 Lung disease severity in cystic fibrosis; CRC cis rs12325245 0.536 rs12709002 chr16:58614337 A/C cg05725404 chr16:58534157 NDRG4 -0.59 -5.75 -0.3 2.09e-8 Schizophrenia; CRC cis rs6502050 0.835 rs35070385 chr17:80128447 G/A cg19223190 chr17:80058835 NA 0.38 6.02 0.32 4.64e-9 Life satisfaction; CRC trans rs2303319 0.504 rs62189054 chr2:162624654 C/G cg22922770 chr7:98923339 ARPC1A -0.67 -5.99 -0.31 5.55e-9 Cognitive function; CRC cis rs9311676 0.618 rs62258135 chr3:58403330 C/T cg06643156 chr3:58380774 PXK 0.42 6.38 0.33 5.84e-10 Systemic lupus erythematosus; CRC cis rs6754459 0.502 rs34759180 chr2:3707394 C/T cg19825600 chr2:3704501 ALLC -0.61 -6.79 -0.35 5.3e-11 Response to inhaled corticosteroid treatment in asthma (change in FEV1); CRC cis rs2243480 1.000 rs186378 chr7:65582058 A/C cg25985355 chr7:65971099 NA -0.49 -5.73 -0.3 2.27e-8 Diabetic kidney disease; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg02751803 chr16:56998622 CETP 0.47 6.4 0.33 5.35e-10 Anxiety disorder; CRC trans rs2797160 1.000 rs1777195 chr6:126006861 A/C cg05039488 chr6:79577232 IRAK1BP1 0.49 7.19 0.37 4.34e-12 Endometrial cancer; CRC cis rs172166 0.694 rs203892 chr6:28067196 T/C cg25164649 chr6:28176230 NA 0.62 8.85 0.44 5.46e-17 Cardiac Troponin-T levels; CRC cis rs7618915 0.547 rs11720432 chr3:52672742 T/C cg08222913 chr3:52553049 STAB1 -0.34 -6.1 -0.32 3.03e-9 Bipolar disorder; CRC cis rs7408868 0.908 rs45591935 chr19:15277006 T/C cg14696996 chr19:15285081 NOTCH3 0.96 9.0 0.44 1.82e-17 Pulse pressure; CRC cis rs11212617 0.934 rs609557 chr11:108084513 G/T cg14761454 chr11:108092087 ATM;NPAT 0.41 6.28 0.33 1.08e-9 Response to metformin in type 2 diabetes (glycemic); CRC cis rs4665809 1.000 rs6739061 chr2:26256147 C/T cg25036284 chr2:26402008 FAM59B -0.44 -5.86 -0.31 1.15e-8 Gut microbiome composition (summer); CRC cis rs875971 0.862 rs28470208 chr7:65584700 A/G cg18876405 chr7:65276391 NA -0.51 -8.38 -0.42 1.58e-15 Aortic root size; CRC cis rs782590 0.608 rs10207590 chr2:55921782 G/C cg18811423 chr2:55921094 PNPT1 -0.82 -14.57 -0.63 1.89e-37 Metabolic syndrome; CRC cis rs11758351 0.518 rs79922979 chr6:26224975 A/G cg22723502 chr6:26240528 HIST1H4F -0.36 -5.85 -0.31 1.16e-8 Gout;Renal underexcretion gout; CRC cis rs116095464 0.558 rs6878061 chr5:223072 A/G cg22496380 chr5:211416 CCDC127 -0.83 -9.55 -0.47 3.03e-19 Breast cancer; CRC cis rs7809950 0.798 rs2701687 chr7:107304628 C/T cg23024343 chr7:107201750 COG5 0.47 7.0 0.36 1.49e-11 Coronary artery disease; CRC cis rs4434138 0.664 rs62255364 chr3:52701502 C/T cg10802521 chr3:52805072 NEK4 -0.58 -8.88 -0.44 4.3e-17 Intelligence (multi-trait analysis); CRC trans rs9467711 0.790 rs10484439 chr6:26309908 G/A cg06606381 chr12:133084897 FBRSL1 -0.95 -6.8 -0.35 4.91e-11 Autism spectrum disorder or schizophrenia; CRC cis rs7215564 0.908 rs74002838 chr17:78682157 C/T cg09596252 chr17:78655493 RPTOR 0.56 6.15 0.32 2.26e-9 Myopia (pathological); CRC cis rs9916302 0.861 rs11078896 chr17:37415544 C/T cg07936489 chr17:37558343 FBXL20 -0.78 -11.72 -0.54 9.6800000000000007e-27 Glomerular filtration rate (creatinine); CRC cis rs6089584 0.888 rs6061983 chr20:60621202 T/C cg23463467 chr20:60627584 TAF4 0.33 5.72 0.3 2.4e-8 Body mass index; CRC cis rs853679 0.517 rs2281588 chr6:28072602 G/A cg03623178 chr6:28175578 NA 0.96 12.48 0.57 1.62e-29 Depression; CRC cis rs7762018 0.882 rs4716342 chr6:170137959 A/G cg24289452 chr6:170231220 NA -0.56 -6.12 -0.32 2.64e-9 Thiazide-induced adverse metabolic effects in hypertensive patients; CRC cis rs4700695 0.719 rs1643415 chr5:65447087 T/C cg21114390 chr5:65439923 SFRS12 -0.65 -8.66 -0.43 2.15e-16 Facial morphology (factor 19); CRC cis rs513349 0.964 rs210141 chr6:33546825 T/C cg24505687 chr6:33548425 BAK1 0.32 6.24 0.33 1.33e-9 Platelet count; CRC cis rs6735179 0.600 rs57620327 chr2:1778208 G/T cg19300414 chr2:1746591 PXDN 0.37 6.26 0.33 1.19e-9 Response to antipsychotic treatment; CRC cis rs2836974 0.965 rs6517538 chr21:40656242 C/T cg11890956 chr21:40555474 PSMG1 1.11 19.05 0.72 4.69e-55 Cognitive function; CRC cis rs9534288 0.912 rs4941540 chr13:46604710 C/T cg15192986 chr13:46630673 CPB2 -0.72 -10.3 -0.49 9.63e-22 Blood protein levels; CRC cis rs12594515 1.000 rs6493170 chr15:45987019 G/A cg01629716 chr15:45996671 NA 0.41 8.55 0.43 4.56e-16 Waist circumference;Weight; CRC cis rs4820294 1.000 rs929039 chr22:38071511 T/C cg21798802 chr22:38057573 PDXP 0.46 7.44 0.38 9.12e-13 Fat distribution (HIV); CRC cis rs1150668 0.699 rs1736895 chr6:28219826 G/A cg25164649 chr6:28176230 NA 0.38 5.7 0.3 2.65e-8 Pubertal anthropometrics; CRC trans rs61931739 0.534 rs1705757 chr12:34091637 A/G cg26384229 chr12:38710491 ALG10B 0.53 7.28 0.37 2.42e-12 Morning vs. evening chronotype; CRC cis rs748404 0.560 rs2255663 chr15:43829008 A/G cg02155558 chr15:43621948 ADAL;LCMT2 -0.49 -7.16 -0.37 5.34e-12 Lung cancer; CRC cis rs10779751 0.734 rs2791653 chr1:11129848 A/G cg08854313 chr1:11322531 MTOR 0.66 8.74 0.43 1.17e-16 Body mass index; CRC cis rs62064224 0.714 rs62064225 chr17:30635429 C/T cg21839984 chr17:30846986 MYO1D -0.33 -5.74 -0.3 2.15e-8 Schizophrenia; CRC cis rs769267 0.965 rs2074299 chr19:19380646 T/C cg03709012 chr19:19516395 GATAD2A 0.71 10.98 0.52 4.21e-24 Tonsillectomy; CRC cis rs6060717 0.536 rs6060666 chr20:34478954 C/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.5 -5.99 -0.31 5.58e-9 Hip circumference adjusted for BMI; CRC cis rs7552404 1.000 rs211723 chr1:76103030 C/T cg22875332 chr1:76189707 ACADM -0.65 -8.9 -0.44 3.77e-17 Blood metabolite levels;Acylcarnitine levels; CRC cis rs3540 0.804 rs3743418 chr15:90934331 A/G cg22089800 chr15:90895588 ZNF774 0.46 5.89 0.31 9.32e-9 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; CRC cis rs72781680 0.848 rs56218741 chr2:23977377 A/C cg08917208 chr2:24149416 ATAD2B 0.86 8.45 0.42 9.69e-16 Lymphocyte counts; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg23615779 chr7:143077590 ZYX 0.39 6.1 0.32 2.97e-9 Intelligence (multi-trait analysis); CRC cis rs6701037 0.555 rs10912899 chr1:175120715 C/T cg14847009 chr1:175162515 KIAA0040 0.28 6.42 0.33 4.72e-10 Alcohol dependence; CRC cis rs2243480 1.000 rs316322 chr7:65611233 G/C cg12463550 chr7:65579703 CRCP 0.73 6.55 0.34 2.23e-10 Diabetic kidney disease; CRC cis rs9914988 0.943 rs9303621 chr17:27161138 A/G cg12682573 chr17:27188876 MIR451;MIR144 0.56 7.74 0.39 1.23e-13 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs561341 1.000 rs560132 chr17:30320019 C/T cg00745463 chr17:30367425 LRRC37B -0.86 -9.45 -0.46 6.4e-19 Hip circumference adjusted for BMI; CRC cis rs860295 0.702 rs11264366 chr1:155335411 A/T cg02153340 chr1:155202674 NA -0.52 -6.43 -0.33 4.51e-10 Body mass index; CRC cis rs2806561 1.000 rs2473851 chr1:23489869 A/G cg19743168 chr1:23544995 NA 0.38 5.98 0.31 5.68e-9 Height; CRC cis rs172166 0.516 rs2622322 chr6:28117443 C/G cg03623178 chr6:28175578 NA 0.66 10.06 0.49 6.13e-21 Cardiac Troponin-T levels; CRC cis rs7584330 0.695 rs7570882 chr2:238435086 G/A cg16989719 chr2:238392110 NA -0.38 -7.71 -0.39 1.48e-13 Prostate cancer; CRC cis rs72781680 0.800 rs6718635 chr2:24066183 A/C cg08917208 chr2:24149416 ATAD2B 1.03 10.11 0.49 4.33e-21 Lymphocyte counts; CRC cis rs6952808 0.656 rs73048919 chr7:2103637 C/A cg20295408 chr7:1910781 MAD1L1 -0.43 -5.8 -0.3 1.52e-8 Bipolar disorder and schizophrenia; CRC cis rs853679 0.517 rs9393888 chr6:28059217 G/C cg02683197 chr6:28174875 NA 0.82 10.03 0.48 7.9e-21 Depression; CRC cis rs71403859 0.803 rs7203606 chr16:71590511 A/C cg08717414 chr16:71523259 ZNF19 -0.93 -8.85 -0.44 5.4e-17 Post bronchodilator FEV1; CRC cis rs7493 1.000 rs2299263 chr7:95040411 A/G cg01874867 chr7:94954059 PON1 0.49 6.31 0.33 8.91e-10 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs72945132 0.714 rs72947077 chr11:70197431 A/G cg00319359 chr11:70116639 PPFIA1 0.65 6.49 0.34 3.12e-10 Coronary artery disease; CRC cis rs1005277 0.579 rs1740732 chr10:38491385 C/T cg03665457 chr10:38645376 HSD17B7P2 -0.41 -5.83 -0.31 1.33e-8 Extrinsic epigenetic age acceleration; CRC cis rs10504229 0.679 rs12675340 chr8:58035501 T/A cg22535103 chr8:58192502 C8orf71 -0.44 -5.84 -0.31 1.25e-8 Developmental language disorder (linguistic errors); CRC cis rs853679 0.517 rs9393901 chr6:28136797 A/G cg25164649 chr6:28176230 NA 0.78 9.66 0.47 1.33e-19 Depression; CRC cis rs12908161 1.000 rs35630683 chr15:85349231 T/C cg17507749 chr15:85114479 UBE2QP1 0.58 8.07 0.41 1.33e-14 Schizophrenia; CRC cis rs597539 0.652 rs478647 chr11:68700424 C/T cg04772025 chr11:68637568 NA 0.47 7.21 0.37 3.76e-12 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs6840360 0.615 rs113052419 chr4:152473008 T/C cg09659197 chr4:152720779 NA 0.3 5.66 0.3 3.28e-8 Intelligence (multi-trait analysis); CRC cis rs1707322 0.928 rs61785614 chr1:46446047 A/G cg03146154 chr1:46216737 IPP 0.51 7.06 0.36 1.01e-11 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs6662572 0.950 rs56093189 chr1:46234323 T/C cg08644498 chr1:46502608 NA 0.44 6.49 0.34 3.11e-10 Blood protein levels; CRC cis rs6684514 1.000 rs10908502 chr1:156300082 A/G cg16558208 chr1:156270281 VHLL 0.56 8.76 0.43 1.06e-16 Mean corpuscular hemoglobin concentration;Glycated hemoglobin levels; CRC cis rs7786808 0.712 rs2335167 chr7:158213948 A/C cg01191920 chr7:158217561 PTPRN2 -0.77 -12.92 -0.58 3.75e-31 Obesity-related traits; CRC trans rs10028773 0.700 rs7671797 chr4:120248157 A/G cg25214090 chr10:38739885 LOC399744 0.53 8.34 0.42 2.08e-15 Educational attainment; CRC cis rs929596 0.585 rs2018985 chr2:234648860 A/G cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.54 -8.35 -0.42 1.95e-15 Total bilirubin levels in HIV-1 infection; CRC cis rs7044106 0.791 rs10739572 chr9:123489815 C/T cg09586646 chr9:123605570 PSMD5;LOC253039 0.66 9.69 0.47 1.08e-19 Hip circumference adjusted for BMI; CRC cis rs6951245 0.744 rs10265736 chr7:1172465 C/T cg21664854 chr7:1097933 C7orf50;GPR146 0.68 8.14 0.41 8.39e-15 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC trans rs2303319 0.504 rs1006427 chr2:162592328 T/C cg25193742 chr10:104614220 C10orf32 -0.77 -6.51 -0.34 2.87e-10 Cognitive function; CRC cis rs57221529 0.766 rs12522140 chr5:587261 C/A cg17948913 chr5:572064 NA 0.55 6.2 0.32 1.71e-9 Lung disease severity in cystic fibrosis; CRC cis rs698833 0.892 rs786618 chr2:44593929 C/T cg04920474 chr2:44395004 PPM1B 0.42 6.11 0.32 2.87e-9 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; CRC cis rs6066835 1.000 rs6125428 chr20:47292823 C/G cg18078177 chr20:47281410 PREX1 0.77 5.69 0.3 2.8e-8 Multiple myeloma; CRC cis rs977987 0.836 rs7200053 chr16:75474618 C/T cg03315344 chr16:75512273 CHST6 0.55 9.35 0.46 1.39e-18 Dupuytren's disease; CRC cis rs1707322 0.717 rs2253862 chr1:46081960 C/T cg03146154 chr1:46216737 IPP -0.67 -9.51 -0.46 4.3e-19 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs1448094 0.549 rs7297996 chr12:86235899 C/T cg00310523 chr12:86230176 RASSF9 0.35 5.87 0.31 1.07e-8 Major depressive disorder; CRC cis rs4319547 0.695 rs4758648 chr12:122900460 A/G cg23029597 chr12:123009494 RSRC2 -0.54 -7.15 -0.37 5.58e-12 Body mass index; CRC cis rs9640161 0.789 rs1464752 chr7:150021284 C/T cg12556325 chr7:150026731 C7orf29;LRRC61 -0.43 -6.41 -0.33 4.9e-10 Blood protein levels;Circulating chemerin levels; CRC cis rs919433 0.963 rs12617117 chr2:198155170 T/A cg20885578 chr2:198174922 NA -0.44 -6.93 -0.36 2.26e-11 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg16178625 chr17:56609274 SEPT4 0.38 6.48 0.34 3.44e-10 Liver disease severity in Alagille syndrome; CRC cis rs4972806 0.668 rs2072588 chr2:177042930 G/C cg09355771 chr2:177043147 NA 0.68 10.3 0.49 9.55e-22 IgG glycosylation; CRC cis rs9393692 0.846 rs9366651 chr6:26336696 G/T cg00631329 chr6:26305371 NA -0.68 -13.25 -0.59 2e-32 Educational attainment; CRC cis rs7567389 0.600 rs3732209 chr2:128079806 A/G cg09760422 chr2:128146352 NA 0.34 5.72 0.3 2.38e-8 Self-rated health; CRC cis rs7835763 0.518 rs2468133 chr8:119095747 C/T cg11592677 chr8:119110466 EXT1 -0.43 -7.52 -0.38 5.29e-13 Autism spectrum disorder; CRC cis rs73058052 0.597 rs11878568 chr19:50095961 T/C cg15963326 chr19:50037085 RCN3 -0.36 -5.74 -0.3 2.15e-8 Fibrinogen levels; CRC cis rs595982 0.559 rs73061643 chr19:49368151 A/G cg15549821 chr19:49342101 PLEKHA4 -0.56 -6.6 -0.34 1.62e-10 Red cell distribution width; CRC cis rs9303401 0.659 rs16943176 chr17:56769887 G/A cg02118635 chr17:56770003 RAD51C;TEX14 0.79 10.13 0.49 3.5e-21 Cognitive test performance; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg16866257 chr17:61905183 FTSJ3;PSMC5 0.44 6.43 0.33 4.38e-10 Response to antipsychotic treatment; CRC cis rs11690935 0.571 rs13020884 chr2:172901699 T/G cg13550731 chr2:172543902 DYNC1I2 0.65 9.37 0.46 1.19e-18 Schizophrenia; CRC trans rs6703335 0.870 rs10803142 chr1:243598234 A/G cg14010720 chr20:62168878 PTK6 0.31 5.96 0.31 6.5e-9 Schizophrenia;Schizophrenia, schizoaffective disorder or bipolar disorder; CRC cis rs7618915 0.501 rs2336149 chr3:52692124 G/A cg05573699 chr3:52720067 GNL3;PBRM1 -0.48 -7.01 -0.36 1.36e-11 Bipolar disorder; CRC cis rs3806843 0.576 rs246030 chr5:140333154 C/G cg19875535 chr5:140030758 IK 0.4 6.12 0.32 2.64e-9 Depressive symptoms (multi-trait analysis); CRC cis rs7223966 1.000 rs15637 chr17:61772050 C/G cg23903597 chr17:61704154 MAP3K3 -0.43 -5.85 -0.31 1.19e-8 Hip circumference adjusted for BMI;Body mass index; CRC cis rs2032447 0.839 rs199751 chr6:26015583 T/C cg03264133 chr6:25882463 NA -0.52 -7.12 -0.37 6.97e-12 Intelligence (multi-trait analysis); CRC trans rs2797369 0.882 rs1775644 chr6:101615409 T/C cg26346621 chr12:6873348 NA -0.38 -6.1 -0.32 2.96e-9 Renal function-related traits (eGRFcrea); CRC cis rs950027 0.596 rs2467853 chr15:45698793 T/G cg10760299 chr15:45669010 GATM 0.36 5.61 0.3 4.34e-8 Response to fenofibrate (adiponectin levels); CRC cis rs9311474 0.597 rs6778735 chr3:52565100 T/C cg05573699 chr3:52720067 GNL3;PBRM1 -0.39 -5.91 -0.31 8.51e-9 Electroencephalogram traits; CRC cis rs12971120 0.947 rs7241558 chr18:72169267 A/T cg25817165 chr18:72167213 CNDP2 -0.66 -11.59 -0.54 2.83e-26 Refractive error; CRC cis rs6504622 0.902 rs1052586 chr17:45018463 A/G cg16759221 chr17:45003025 GOSR2 0.47 7.46 0.38 7.58e-13 Orofacial clefts; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg02865149 chr11:58939797 DTX4 0.45 6.56 0.34 2.13e-10 Intelligence (multi-trait analysis); CRC cis rs911555 0.755 rs8014013 chr14:103937372 A/G cg12935359 chr14:103987150 CKB 0.55 8.38 0.42 1.61e-15 Intelligence (multi-trait analysis); CRC cis rs6694672 1.000 rs1170882 chr1:196949323 C/G cg13682187 chr1:196946512 CFHR5 -0.48 -7.61 -0.39 2.83e-13 Asthma; CRC cis rs12497850 1.000 rs12493578 chr3:48730116 C/T cg20833759 chr3:49053208 WDR6;DALRD3 -0.43 -7.31 -0.37 2.09e-12 Parkinson's disease; CRC cis rs12142240 0.698 rs72886911 chr1:46814352 G/A cg00530320 chr1:46809349 NSUN4 0.58 7.81 0.4 7.54e-14 Menopause (age at onset); CRC cis rs55823223 0.646 rs55868394 chr17:73851113 C/A cg08125733 chr17:73851984 WBP2 0.99 8.45 0.42 9.59e-16 Psoriasis; CRC cis rs1862618 0.853 rs252922 chr5:56136343 G/T cg24531977 chr5:56204891 C5orf35 -0.8 -10.8 -0.51 1.79e-23 Initial pursuit acceleration; CRC trans rs11098499 0.774 rs11098505 chr4:120284627 C/T cg25214090 chr10:38739885 LOC399744 0.61 9.66 0.47 1.39e-19 Corneal astigmatism; CRC cis rs4423214 0.765 rs2002064 chr11:71163420 A/G cg13043300 chr11:71146211 DHCR7 -0.44 -5.84 -0.31 1.28e-8 Vitamin D levels; CRC trans rs4942242 0.663 rs34595450 chr13:44221245 A/G cg26741380 chr15:41871084 TYRO3 -0.49 -6.87 -0.35 3.14e-11 Response to tocilizumab in rheumatoid arthritis; CRC cis rs17162190 0.698 rs6675469 chr1:26789813 G/A cg17456097 chr1:26900765 RPS6KA1 0.46 6.58 0.34 1.82e-10 Mean corpuscular volume; CRC cis rs931127 0.547 rs3886859 chr11:65458310 C/T cg27068330 chr11:65405492 SIPA1 -0.43 -5.9 -0.31 8.91e-9 Systemic lupus erythematosus; CRC cis rs9611565 0.592 rs5751101 chr22:41828111 C/T cg06634786 chr22:41940651 POLR3H 0.71 7.8 0.39 8.36e-14 Vitiligo; CRC cis rs2276314 0.553 rs4799842 chr18:33627968 C/A cg05985134 chr18:33552581 C18orf21 0.38 5.92 0.31 8.05e-9 Endometriosis;Drug-induced torsades de pointes; CRC cis rs3793683 0.928 rs2148666 chr10:134553785 A/G cg06453172 chr10:134556979 INPP5A -0.48 -7.43 -0.38 9.23e-13 Migraine; CRC cis rs8031584 0.723 rs711224 chr15:31127921 G/C cg08109568 chr15:31115862 NA 0.66 10.52 0.5 1.68e-22 Huntington's disease progression; CRC cis rs2564921 0.570 rs3821831 chr3:52853401 C/T cg11645453 chr3:52864694 ITIH4 -0.38 -6.4 -0.33 5.37e-10 Height; CRC cis rs2820315 0.505 rs10800792 chr1:201811144 G/A cg11586189 chr1:201857591 SHISA4 0.38 6.26 0.33 1.17e-9 Body mass index;Body mass index (joint analysis main effects and physical activity interaction);Coronary artery disease;Body mass index in physically active individuals; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg11190155 chr3:9975447 CRELD1 0.5 6.44 0.33 4.25e-10 Thyroid stimulating hormone; CRC cis rs2440129 0.632 rs2292353 chr17:6903537 C/T cg03760483 chr17:6899297 ALOX12 0.61 11.2 0.53 6.96e-25 Tonsillectomy; CRC cis rs12477438 0.501 rs9941561 chr2:99753829 A/C cg26064155 chr2:99771622 LIPT1;TSGA10 0.83 14.66 0.63 8.22e-38 Chronic sinus infection; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg03797687 chr12:111843585 SH2B3 0.51 6.88 0.35 3.11e-11 Anxiety disorder; CRC cis rs1448094 0.872 rs7314272 chr12:86401005 T/C cg18827107 chr12:86230957 RASSF9 -0.36 -5.77 -0.3 1.83e-8 Major depressive disorder; CRC trans rs1814175 0.538 rs1684260 chr11:49224231 G/A cg03929089 chr4:120376271 NA 0.8 13.26 0.59 1.85e-32 Height; CRC cis rs7584330 0.504 rs11884519 chr2:238425283 T/C cg14458575 chr2:238380390 NA 0.46 6.53 0.34 2.57e-10 Prostate cancer; CRC cis rs1448094 0.935 rs11117120 chr12:86336447 G/A cg19622623 chr12:86230825 RASSF9 -0.36 -5.94 -0.31 7.17e-9 Major depressive disorder; CRC cis rs2976388 0.609 rs2585144 chr8:143800269 A/T cg12516270 chr8:143859308 LYNX1 0.43 7.56 0.38 4.03e-13 Urinary tract infection frequency; CRC cis rs3106136 0.872 rs2059605 chr4:95255212 C/T cg11021082 chr4:95130006 SMARCAD1 -0.39 -6.0 -0.31 5.08e-9 Capecitabine sensitivity; CRC cis rs863345 0.625 rs10752626 chr1:158528118 G/A cg12129480 chr1:158549410 OR10X1 -0.35 -7.29 -0.37 2.3e-12 Pneumococcal bacteremia; CRC cis rs2204008 0.805 rs4882575 chr12:37940573 G/A cg26384229 chr12:38710491 ALG10B -0.65 -9.69 -0.47 1.04e-19 Bladder cancer; CRC trans rs2303319 0.504 rs62189053 chr2:162624324 G/A cg22988483 chr14:93581567 ITPK1 -0.66 -6.08 -0.32 3.32e-9 Cognitive function; CRC cis rs8031584 0.678 rs4779496 chr15:31151054 A/G cg14829155 chr15:31115871 NA -0.65 -10.19 -0.49 2.28e-21 Huntington's disease progression; CRC cis rs4555082 0.834 rs2816652 chr14:105712493 C/T cg13114125 chr14:105738426 BRF1 -0.8 -11.97 -0.55 1.22e-27 Mean platelet volume;Platelet distribution width; CRC cis rs9462027 0.583 rs9469862 chr6:34729848 A/G cg07306190 chr6:34760872 UHRF1BP1 -0.35 -6.19 -0.32 1.75e-9 Systemic lupus erythematosus; CRC cis rs875971 0.502 rs6460311 chr7:66111873 C/T cg03233332 chr7:66118400 NA 0.43 5.84 0.31 1.23e-8 Aortic root size; CRC cis rs7633770 0.965 rs6804112 chr3:46686248 C/T cg11219411 chr3:46661640 NA 0.61 9.9 0.48 2.08e-20 Coronary artery disease; CRC cis rs4853012 0.838 rs72915068 chr2:74356185 G/A cg05890377 chr2:74357713 NA 0.66 10.65 0.51 6.11e-23 Gestational age at birth (maternal effect); CRC cis rs6061231 0.624 rs8668 chr20:60964064 C/T cg22601191 chr20:60968625 CABLES2 -0.37 -6.41 -0.33 5.03e-10 Colorectal cancer; CRC cis rs1983170 0.736 rs12127718 chr1:91997490 A/T cg02896835 chr1:92012615 NA 0.49 5.82 0.31 1.38e-8 Eosinophil percentage of white cells; CRC cis rs35146811 0.961 rs35991721 chr7:99728790 G/T cg22906224 chr7:99728672 NA 0.49 5.74 0.3 2.17e-8 Coronary artery disease; CRC cis rs72781680 0.898 rs72780111 chr2:23991146 G/A cg08917208 chr2:24149416 ATAD2B 0.87 8.46 0.42 8.88e-16 Lymphocyte counts; CRC cis rs7917772 0.503 rs7078435 chr10:104304766 T/C cg22532475 chr10:104410764 TRIM8 -0.35 -6.51 -0.34 2.89e-10 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC cis rs7208859 0.623 rs7223209 chr17:29107220 C/A cg01831904 chr17:28903510 LRRC37B2 -0.63 -6.45 -0.33 4.07e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs2576037 0.542 rs4630643 chr18:44508142 G/A cg07643061 chr18:44555308 TCEB3C;TCEB3CL;KATNAL2 -0.34 -5.62 -0.3 4.08e-8 Personality dimensions; CRC cis rs3806843 0.735 rs813897 chr5:140070029 T/C cg19875535 chr5:140030758 IK -0.63 -10.37 -0.5 5.57e-22 Depressive symptoms (multi-trait analysis); CRC trans rs7395662 0.736 rs4882036 chr11:48749384 A/G cg21153622 chr11:89784906 NA -0.48 -7.69 -0.39 1.74e-13 HDL cholesterol; CRC cis rs9914988 0.943 rs9902953 chr17:27139834 C/A cg20469991 chr17:27169893 C17orf63 -0.6 -7.22 -0.37 3.63e-12 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs7811142 0.887 rs35111986 chr7:100000274 C/A cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.14 15.74 0.66 5.48e-42 Platelet count; CRC cis rs2295359 0.892 rs10789224 chr1:67605134 C/T cg03340356 chr1:67600835 NA -0.27 -6.16 -0.32 2.09e-9 Psoriasis; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg10835914 chr14:73493957 ZFYVE1 0.46 6.65 0.34 1.22e-10 Intelligence (multi-trait analysis); CRC cis rs8177253 0.965 rs1525889 chr3:133490033 A/C cg16262614 chr3:133464971 TF 0.34 6.0 0.31 5.25e-9 Iron status biomarkers; CRC cis rs362272 0.505 rs60208975 chr4:3364530 A/G cg11522145 chr4:3412961 RGS12 -0.41 -6.35 -0.33 7.04e-10 Serum sulfate level; CRC cis rs853679 0.546 rs493161 chr6:27850714 A/T cg03623178 chr6:28175578 NA 0.79 6.63 0.34 1.35e-10 Depression; CRC cis rs6912958 0.712 rs7772561 chr6:88331299 A/G cg08069147 chr6:88032118 GJB7;C6orf162 -0.57 -8.61 -0.43 3.14e-16 Monocyte percentage of white cells; CRC cis rs13108904 0.870 rs4974543 chr4:1251222 A/G cg21620606 chr4:1342894 KIAA1530 0.4 6.94 0.36 2.06e-11 Obesity-related traits; CRC cis rs57221529 1.000 rs57221529 chr5:586624 A/G cg16447950 chr5:562315 NA -0.74 -9.65 -0.47 1.44e-19 Lung disease severity in cystic fibrosis; CRC cis rs67340775 0.541 rs200964 chr6:27866943 G/C cg26587870 chr6:27730563 NA -0.53 -6.15 -0.32 2.26e-9 Lung cancer in ever smokers; CRC cis rs2832191 0.720 rs2832200 chr21:30499165 G/A cg08807101 chr21:30365312 RNF160 -0.62 -9.68 -0.47 1.16e-19 Dental caries; CRC trans rs1367248 0.943 rs55937534 chr2:125005052 A/T cg07402188 chr19:40720005 MAP3K10 0.46 6.04 0.32 4.18e-9 Tonometry; CRC cis rs7586879 0.789 rs13382979 chr2:25131736 G/A cg04586622 chr2:25135609 ADCY3 -0.56 -9.26 -0.45 2.66e-18 Body mass index; CRC cis rs2795502 0.564 rs11239842 chr10:43444882 A/G cg20628663 chr10:43360327 NA 0.57 6.89 0.36 2.77e-11 Blood protein levels; CRC cis rs6545883 0.507 rs4672427 chr2:61469250 A/G cg10580144 chr2:61372316 C2orf74 -0.35 -7.65 -0.39 2.18e-13 Tuberculosis; CRC cis rs7552404 1.000 rs942270 chr1:76177332 G/A cg10523679 chr1:76189770 ACADM 0.83 11.22 0.53 5.83e-25 Blood metabolite levels;Acylcarnitine levels; CRC cis rs490234 0.812 rs12351825 chr9:128265736 T/C cg14078157 chr9:128172775 NA -0.39 -6.58 -0.34 1.88e-10 Mean arterial pressure; CRC cis rs3858526 0.628 rs1840177 chr11:5944627 T/G cg02574844 chr11:5959923 NA 0.53 8.72 0.43 1.4e-16 DNA methylation (variation); CRC cis rs7954584 0.567 rs1169071 chr12:122390084 G/T cg21171335 chr12:122356390 WDR66 0.39 5.93 0.31 7.63e-9 Mean corpuscular volume; CRC cis rs6754311 0.597 rs2082729 chr2:136550109 C/T cg15123519 chr2:136567270 LCT 0.31 5.83 0.31 1.36e-8 Mosquito bite size; CRC trans rs1814175 0.616 rs28417656 chr11:50040152 C/T cg11707556 chr5:10655725 ANKRD33B -0.5 -9.83 -0.48 3.72e-20 Height; CRC trans rs1455244 0.700 rs7229302 chr18:11508904 G/T cg02761523 chr19:13106643 NFIX 0.41 6.18 0.32 1.9e-9 Schizophrenia; CRC cis rs10504229 0.636 rs72649133 chr8:58054681 G/A cg08219700 chr8:58056026 NA 0.59 6.71 0.35 8.27e-11 Developmental language disorder (linguistic errors); CRC cis rs801193 0.773 rs801207 chr7:66020590 T/C cg11764359 chr7:65958608 NA -0.49 -7.61 -0.39 2.94e-13 Aortic root size; CRC cis rs10504229 0.683 rs2005392 chr8:58106896 T/C cg24829409 chr8:58192753 C8orf71 -0.56 -8.01 -0.4 2.05e-14 Developmental language disorder (linguistic errors); CRC cis rs2404602 0.692 rs34478400 chr15:76923510 C/T cg22467129 chr15:76604101 ETFA -0.39 -6.44 -0.33 4.14e-10 Blood metabolite levels; CRC cis rs4819052 0.851 rs7279182 chr21:46656112 G/A cg11663144 chr21:46675770 NA -0.82 -13.31 -0.59 1.19e-32 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC trans rs11098499 0.863 rs3775848 chr4:120447724 C/T cg25214090 chr10:38739885 LOC399744 0.65 10.1 0.49 4.61e-21 Corneal astigmatism; CRC cis rs7632954 0.867 rs9857796 chr3:8514503 A/G cg03495237 chr3:8533978 NA 0.34 5.7 0.3 2.66e-8 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs72781680 0.716 rs2675363 chr2:24080003 G/C cg08917208 chr2:24149416 ATAD2B 0.57 6.86 0.35 3.48e-11 Lymphocyte counts; CRC cis rs597539 0.652 rs686877 chr11:68637169 G/A cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.89 15.85 0.66 1.89e-42 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs4713118 0.699 rs200978 chr6:27853168 C/G cg03623178 chr6:28175578 NA 0.82 10.81 0.51 1.7e-23 Parkinson's disease; CRC cis rs2439831 0.850 rs28476182 chr15:44139643 C/T cg02155558 chr15:43621948 ADAL;LCMT2 0.65 7.16 0.37 5.44e-12 Lung cancer in ever smokers; CRC cis rs1401999 0.899 rs2313211 chr3:183738626 T/A cg05044414 chr3:183734942 ABCC5 0.47 8.19 0.41 5.96e-15 Anterior chamber depth; CRC cis rs7618915 0.501 rs2289247 chr3:52727257 C/T cg11645453 chr3:52864694 ITIH4 0.33 5.87 0.31 1.07e-8 Bipolar disorder; CRC cis rs11212617 0.967 rs60683001 chr11:108257787 T/C cg01991180 chr11:108092276 ATM;NPAT 0.44 6.61 0.34 1.59e-10 Response to metformin in type 2 diabetes (glycemic); CRC cis rs6951245 0.935 rs61753396 chr7:1105372 A/G cg22907277 chr7:1156413 C7orf50 0.74 7.89 0.4 4.63e-14 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs6831352 0.918 rs2602895 chr4:100045840 C/T cg13256891 chr4:100009986 ADH5 0.65 8.93 0.44 3.15e-17 Alcohol dependence; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg07975834 chr1:112282151 C1orf183 0.45 6.18 0.32 1.9e-9 Anxiety disorder; CRC cis rs6502050 0.835 rs34673303 chr17:80085144 G/C cg13198984 chr17:80129470 CCDC57 -0.48 -8.56 -0.43 4.49e-16 Life satisfaction; CRC cis rs4481887 0.504 rs7548525 chr1:248360026 A/G cg00666640 chr1:248458726 OR2T12 0.43 6.83 0.35 4.14e-11 Common traits (Other); CRC cis rs7552404 1.000 rs12126607 chr1:76217097 G/A cg03433033 chr1:76189801 ACADM 0.81 11.15 0.52 1.08e-24 Blood metabolite levels;Acylcarnitine levels; CRC cis rs7769051 1.000 rs12203977 chr6:133122760 A/G cg07930552 chr6:133119739 C6orf192 0.63 7.69 0.39 1.76e-13 Type 2 diabetes nephropathy; CRC cis rs2836974 0.897 rs8133146 chr21:40614298 T/C cg06238570 chr21:40685208 BRWD1 0.78 10.89 0.51 8.6e-24 Cognitive function; CRC cis rs896854 0.967 rs2879813 chr8:95960947 A/G cg23172400 chr8:95962367 TP53INP1 -0.48 -8.2 -0.41 5.52e-15 Type 2 diabetes; CRC cis rs4665809 1.000 rs6546727 chr2:26275282 C/T cg04944784 chr2:26401820 FAM59B -0.6 -7.68 -0.39 1.89e-13 Gut microbiome composition (summer); CRC cis rs7523050 0.730 rs41279678 chr1:109440215 G/A cg08274380 chr1:109419600 GPSM2 0.9 7.76 0.39 1.12e-13 Fat distribution (HIV); CRC cis rs1577917 0.874 rs11756621 chr6:86740063 G/A cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.58 -7.1 -0.36 7.78e-12 Response to antipsychotic treatment; CRC trans rs3733585 0.699 rs6839490 chr4:9965000 C/G cg26043149 chr18:55253948 FECH 0.5 7.79 0.39 8.77e-14 Cleft plate (environmental tobacco smoke interaction); CRC cis rs13108904 0.901 rs4493484 chr4:1279944 G/A cg00684032 chr4:1343700 KIAA1530 0.48 7.08 0.36 8.57e-12 Obesity-related traits; CRC trans rs11148252 0.840 rs4369550 chr13:52744910 A/G cg18335740 chr13:41363409 SLC25A15 0.53 8.32 0.42 2.34e-15 Lewy body disease; CRC cis rs7647973 0.626 rs4855833 chr3:49657441 A/G cg03060546 chr3:49711283 APEH 0.66 8.09 0.41 1.18e-14 Menarche (age at onset); CRC cis rs6860806 0.507 rs635620 chr5:131720263 A/G cg04518342 chr5:131593106 PDLIM4 -0.44 -7.18 -0.37 4.77e-12 Breast cancer; CRC cis rs17767392 0.813 rs12891975 chr14:71789862 T/C cg13720639 chr14:72061746 SIPA1L1 -0.45 -6.0 -0.31 5.14e-9 Mitral valve prolapse; CRC cis rs921968 0.591 rs3731877 chr2:219602499 G/C cg02176678 chr2:219576539 TTLL4 -0.39 -6.36 -0.33 6.7e-10 Mean corpuscular hemoglobin concentration; CRC cis rs7762018 0.607 rs77972667 chr6:170130456 G/C cg19338460 chr6:170058176 WDR27 -1.24 -10.24 -0.49 1.53e-21 Thiazide-induced adverse metabolic effects in hypertensive patients; CRC cis rs9910055 0.529 rs228749 chr17:42174570 A/G cg10896456 chr17:42255109 ASB16;C17orf65 -0.39 -5.99 -0.31 5.51e-9 Total body bone mineral density; CRC cis rs728616 0.557 rs17107449 chr10:81715696 C/T cg11900509 chr10:81946545 ANXA11 -0.66 -6.6 -0.34 1.67e-10 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs28386778 0.897 rs2727320 chr17:61865325 T/C cg23090583 chr17:61904693 PSMC5;FTSJ3 1.05 20.28 0.75 7.02e-60 Prudent dietary pattern; CRC cis rs425277 0.606 rs2503705 chr1:2076741 A/G cg24578937 chr1:2090814 PRKCZ 0.38 6.96 0.36 1.81e-11 Height; CRC trans rs1455244 0.700 rs7229302 chr18:11508904 G/T cg11541479 chr19:11039306 YIPF2;C19orf52 0.4 6.1 0.32 3.02e-9 Schizophrenia; CRC trans rs12543645 0.609 rs35112858 chr8:10277269 C/T cg06636001 chr8:8085503 FLJ10661 0.46 6.4 0.33 5.25e-10 Schizophrenia; CRC cis rs561341 0.882 rs111484028 chr17:30287701 G/A cg23018236 chr17:30244563 NA -0.57 -7.48 -0.38 6.78e-13 Hip circumference adjusted for BMI; CRC cis rs6598955 0.670 rs7520517 chr1:26556385 A/C cg00852783 chr1:26633632 UBXN11 0.44 7.15 0.37 5.77e-12 Obesity-related traits; CRC cis rs2836974 0.965 rs9941894 chr21:40634058 C/T cg06238570 chr21:40685208 BRWD1 0.75 10.21 0.49 1.91e-21 Cognitive function; CRC cis rs4975709 0.589 rs4975745 chr5:1861058 G/C cg15595755 chr5:1867978 NA 0.37 6.22 0.32 1.52e-9 Cardiovascular disease risk factors; CRC cis rs875971 1.000 rs7801282 chr7:65613687 C/T cg11764359 chr7:65958608 NA -0.62 -9.95 -0.48 1.43e-20 Aortic root size; CRC cis rs3820068 0.603 rs56032936 chr1:15970953 T/C cg13390004 chr1:15929781 NA 0.53 7.41 0.38 1.07e-12 Systolic blood pressure; CRC cis rs873946 0.648 rs12783354 chr10:134557235 T/A cg06453172 chr10:134556979 INPP5A -0.67 -7.86 -0.4 5.54e-14 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CRC cis rs9549260 0.755 rs7338669 chr13:41200091 C/T cg21288729 chr13:41239152 FOXO1 -0.42 -6.73 -0.35 7.76e-11 Red blood cell count; CRC cis rs7731657 0.509 rs916956 chr5:130331705 C/G cg08523029 chr5:130500466 HINT1 -0.46 -5.91 -0.31 8.53e-9 Fasting plasma glucose; CRC cis rs6952808 0.792 rs35582663 chr7:1948756 G/A cg02951883 chr7:2050386 MAD1L1 -0.71 -11.07 -0.52 2.09e-24 Bipolar disorder and schizophrenia; CRC cis rs1799949 0.501 rs35399157 chr17:41411602 G/C cg19454999 chr17:41278357 BRCA1;NBR2 0.52 8.15 0.41 7.64e-15 Menopause (age at onset); CRC cis rs77216612 0.840 rs11055030 chr12:12878349 G/C cg04607235 chr12:12878440 APOLD1 -1.01 -13.6 -0.6 1e-33 Lymphocyte counts; CRC cis rs1005277 0.579 rs2474586 chr10:38418882 T/C cg17219203 chr10:38645113 HSD17B7P2 -0.4 -5.66 -0.3 3.24e-8 Extrinsic epigenetic age acceleration; CRC cis rs7618915 0.524 rs10433615 chr3:52638482 C/T cg18404041 chr3:52824283 ITIH1 -0.43 -8.72 -0.43 1.39e-16 Bipolar disorder; CRC trans rs1455244 0.700 rs7229302 chr18:11508904 G/T cg10706266 chr8:66546233 ARMC1 0.4 6.09 0.32 3.1e-9 Schizophrenia; CRC trans rs62103177 0.810 rs62096746 chr18:77619556 T/A cg05926928 chr17:57297772 GDPD1 1.02 10.13 0.49 3.7e-21 Opioid sensitivity; CRC cis rs7666738 0.800 rs13107147 chr4:99028753 C/T cg05340658 chr4:99064831 C4orf37 0.59 8.97 0.44 2.22e-17 Colonoscopy-negative controls vs population controls; CRC cis rs929354 0.772 rs6967764 chr7:156994964 C/T cg17757837 chr7:157058334 UBE3C 0.74 12.6 0.57 5.83e-30 Body mass index; CRC cis rs8072100 0.905 rs9901869 chr17:45575206 G/A cg08085267 chr17:45401833 C17orf57 -0.63 -10.0 -0.48 9.58e-21 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs3749237 1.000 rs3749237 chr3:49770032 C/T cg24308560 chr3:49941425 MST1R -0.43 -6.13 -0.32 2.53e-9 Resting heart rate; CRC cis rs13256369 1.000 rs10103769 chr8:8573036 G/T cg17143192 chr8:8559678 CLDN23 0.47 6.02 0.31 4.72e-9 Obesity-related traits; CRC cis rs365302 0.951 rs1762101 chr6:159643992 G/A cg14500486 chr6:159655392 FNDC1 0.44 6.71 0.35 8.4e-11 Coronary heart disease; CRC cis rs1552244 0.882 rs67895180 chr3:10026079 T/C cg00166722 chr3:10149974 C3orf24 0.61 7.92 0.4 3.81e-14 Alzheimer's disease; CRC cis rs7546094 1.000 rs7415820 chr1:113169449 G/A cg22162597 chr1:113214053 CAPZA1 -0.43 -5.88 -0.31 1.01e-8 Platelet distribution width; CRC cis rs1129187 0.755 rs3818554 chr6:42934620 C/T cg10862848 chr6:42927986 GNMT -0.38 -9.02 -0.45 1.65e-17 Alzheimer's disease in APOE e4+ carriers; CRC cis rs7937682 0.924 rs489783 chr11:111520522 A/G cg19812747 chr11:111475976 SIK2 -0.59 -10.07 -0.49 5.54e-21 Primary sclerosing cholangitis; CRC cis rs17253792 0.822 rs112308750 chr14:56080073 G/A cg01858014 chr14:56050164 KTN1 -0.87 -7.23 -0.37 3.34e-12 Putamen volume; CRC trans rs916888 0.773 rs199443 chr17:44819565 C/T cg22433210 chr17:43662623 NA 0.92 9.75 0.47 6.75e-20 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg17779707 chr20:48807327 CEBPB 0.43 6.1 0.32 2.91e-9 Response to antipsychotic treatment; CRC cis rs11098499 0.954 rs10017543 chr4:120321420 G/A cg09307838 chr4:120376055 NA 0.72 11.06 0.52 2.22e-24 Corneal astigmatism; CRC cis rs35883536 0.611 rs61070860 chr1:101097628 G/A cg14515779 chr1:101123966 NA -0.35 -6.13 -0.32 2.49e-9 Monocyte count; CRC cis rs7917772 0.536 rs4919667 chr10:104426011 A/G cg11453585 chr10:104263688 ACTR1A;SUFU -0.81 -12.63 -0.57 4.36e-30 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC cis rs77633900 0.614 rs2459360 chr15:76868664 C/T cg21673338 chr15:77095150 SCAPER -0.73 -7.57 -0.39 3.81e-13 Non-glioblastoma glioma;Glioma; CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg08089031 chr6:139456240 HECA 0.38 6.17 0.32 2.05e-9 Obesity-related traits; CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg12564526 chr7:66767603 PMS2L4;STAG3L4 0.38 6.21 0.32 1.61e-9 Obesity-related traits; CRC cis rs6860806 0.507 rs272854 chr5:131688017 C/T cg11843238 chr5:131593191 PDLIM4 0.43 7.3 0.37 2.17e-12 Breast cancer; CRC cis rs11764590 0.715 rs55810445 chr7:2103739 C/T cg25834613 chr7:1915315 MAD1L1 -0.42 -5.85 -0.31 1.19e-8 Neuroticism; CRC cis rs9916302 0.851 rs12947620 chr17:37605364 T/C cg03013999 chr17:37608204 MED1 0.45 6.87 0.35 3.15e-11 Glomerular filtration rate (creatinine); CRC cis rs7591163 1.000 rs6738964 chr2:228739135 G/T cg01216370 chr2:228736459 WDR69 -0.45 -5.77 -0.3 1.85e-8 Blood pressure; CRC cis rs1008375 1.000 rs2058339 chr4:17678456 C/T cg04450456 chr4:17643702 FAM184B 0.39 6.27 0.33 1.14e-9 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs7259376 0.807 rs6511348 chr19:22557374 G/A cg02657401 chr19:22469223 NA -0.33 -7.01 -0.36 1.37e-11 Menopause (age at onset); CRC trans rs71007656 1 rs71007656 chr10:37970845 CGGCTG/C cg17830980 chr10:43048298 ZNF37B -0.46 -7.09 -0.36 8.38e-12 Extrinsic epigenetic age acceleration; CRC cis rs748404 0.631 rs8042688 chr15:43638525 G/A cg02155558 chr15:43621948 ADAL;LCMT2 0.54 7.92 0.4 3.64e-14 Lung cancer; CRC cis rs6088580 0.634 rs6087587 chr20:33058628 G/T cg24642439 chr20:33292090 TP53INP2 0.37 6.23 0.32 1.41e-9 Glomerular filtration rate (creatinine); CRC cis rs35264875 0.846 rs72930627 chr11:68867121 C/A cg03469862 chr11:68924853 NA 0.45 5.74 0.3 2.17e-8 Blond vs. brown hair color; CRC cis rs10751667 0.621 rs10794348 chr11:939941 G/A cg06064525 chr11:970664 AP2A2 -0.33 -6.72 -0.35 7.86e-11 Alzheimer's disease (late onset); CRC cis rs1799949 1.000 rs4793189 chr17:41190715 G/A cg01879757 chr17:41196368 BRCA1 -0.41 -6.06 -0.32 3.7e-9 Menopause (age at onset); CRC cis rs965469 1.000 rs6051713 chr20:3265779 C/T cg25506879 chr20:3388711 C20orf194 0.37 5.63 0.3 3.88e-8 IFN-related cytopenia; CRC cis rs6741819 0.654 rs771259 chr2:7123961 A/G cg27144453 chr2:7172511 RNF144A -0.4 -5.87 -0.31 1.06e-8 Response to antipsychotic treatment; CRC cis rs6570726 0.935 rs449377 chr6:145852437 C/G cg23711669 chr6:146136114 FBXO30 0.66 11.89 0.55 2.29e-27 Lobe attachment (rater-scored or self-reported); CRC cis rs2806561 0.964 rs1757041 chr1:23506063 G/A cg19743168 chr1:23544995 NA 0.36 5.71 0.3 2.56e-8 Height; CRC cis rs853679 0.546 rs200977 chr6:27854301 T/C cg03623178 chr6:28175578 NA 0.79 6.61 0.34 1.56e-10 Depression; CRC cis rs7246657 0.943 rs7408563 chr19:37808585 G/C cg23950597 chr19:37808831 NA -0.53 -6.2 -0.32 1.73e-9 Coronary artery calcification; CRC cis rs6964587 0.692 rs6953256 chr7:91575417 C/T cg17063962 chr7:91808500 NA -0.62 -9.91 -0.48 2e-20 Breast cancer; CRC trans rs116095464 0.558 rs9688045 chr5:254035 T/C cg00938859 chr5:1591904 SDHAP3 0.73 7.89 0.4 4.53e-14 Breast cancer; CRC cis rs28386778 0.897 rs896064 chr17:61860932 C/T cg07362569 chr17:61921086 SMARCD2 0.37 5.68 0.3 2.98e-8 Prudent dietary pattern; CRC cis rs6831352 0.819 rs13832 chr4:99993075 C/A cg13256891 chr4:100009986 ADH5 0.47 6.48 0.34 3.32e-10 Alcohol dependence; CRC cis rs10068717 1 rs10068717 chr5:141494934 C/T cg07392085 chr5:141489673 NDFIP1 0.47 7.46 0.38 7.85e-13 Allergic disease (asthma, hay fever or eczema); CRC cis rs10504229 0.636 rs10958525 chr8:58051528 C/A cg02725872 chr8:58115012 NA -0.44 -6.77 -0.35 5.86e-11 Developmental language disorder (linguistic errors); CRC cis rs7849270 1.000 rs3124510 chr9:131899690 C/T cg13538475 chr9:131942899 NA 0.33 6.37 0.33 6.28e-10 Blood metabolite ratios; CRC cis rs1552244 0.751 rs12715665 chr3:10021601 C/T cg16606324 chr3:10149918 C3orf24 0.6 8.14 0.41 8.28e-15 Alzheimer's disease; CRC cis rs7075426 0.512 rs9633738 chr10:88183796 T/A cg07322936 chr10:88137208 NA -0.6 -7.97 -0.4 2.64e-14 Migraine without aura; CRC cis rs1552244 1.000 rs55882090 chr3:10139082 C/T cg10729496 chr3:10149963 C3orf24 0.49 6.78 0.35 5.57e-11 Alzheimer's disease; CRC cis rs9381040 1.000 rs2093396 chr6:41155000 G/A cg09580153 chr6:41068724 NFYA;LOC221442 -0.51 -7.2 -0.37 4.03e-12 Alzheimer's disease (late onset); CRC cis rs10979 0.557 rs9285501 chr6:143915121 G/C cg25407410 chr6:143891975 LOC285740 -0.64 -8.47 -0.42 8.03e-16 Hypospadias; CRC cis rs597539 0.652 rs673821 chr11:68678718 G/T cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.86 14.42 0.62 7.31e-37 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs798554 0.591 rs1182193 chr7:2869240 A/G cg13628971 chr7:2884303 GNA12 0.39 6.08 0.32 3.3e-9 Height; CRC cis rs12477438 0.520 rs2964969 chr2:99782811 G/A cg14399236 chr2:99771627 LIPT1;TSGA10 0.81 14.32 0.62 1.66e-36 Chronic sinus infection; CRC cis rs34172651 0.917 rs200532 chr16:24756148 C/T cg06505273 chr16:24850292 NA -0.38 -5.97 -0.31 6.25e-9 Intelligence (multi-trait analysis); CRC cis rs1865760 1.000 rs12209482 chr6:25909229 T/G cg16482183 chr6:26056742 HIST1H1C 0.54 7.81 0.4 7.71e-14 Height; CRC cis rs853679 0.598 rs9380054 chr6:28067537 G/A cg12172441 chr6:28176163 NA 0.62 7.33 0.37 1.76e-12 Depression; CRC cis rs9479482 0.967 rs1543547 chr6:150346532 T/C cg25797454 chr6:150327115 RAET1K 0.36 6.18 0.32 1.94e-9 Alopecia areata; CRC trans rs1814175 0.645 rs7123448 chr11:49764865 T/G cg11707556 chr5:10655725 ANKRD33B -0.52 -9.76 -0.47 6.35e-20 Height; CRC cis rs35146811 0.624 rs1727134 chr7:99813672 T/C cg13334819 chr7:99746414 C7orf59 0.58 7.43 0.38 9.74e-13 Coronary artery disease; CRC cis rs3800461 0.544 rs41312309 chr6:34498328 C/T cg14254433 chr6:34482411 PACSIN1 -0.67 -6.48 -0.34 3.41e-10 Chronic lymphocytic leukemia; CRC cis rs79349575 0.721 rs9904645 chr17:46969665 A/T cg22482690 chr17:47019901 SNF8 0.48 8.12 0.41 9.53e-15 Type 2 diabetes; CRC cis rs13256369 1.000 rs1109619 chr8:8571616 G/T cg06671706 chr8:8559999 CLDN23 0.56 8.28 0.42 3.11e-15 Obesity-related traits; CRC cis rs2302190 0.882 rs6503869 chr17:56637461 C/G cg12560992 chr17:57184187 TRIM37 0.53 6.15 0.32 2.28e-9 Vitamin D levels; CRC cis rs2019137 0.936 rs2305133 chr2:113956821 C/G cg11763394 chr2:113992921 PAX8;LOC440839;LOC654433 -0.5 -7.08 -0.36 8.77e-12 Lymphocyte counts; CRC cis rs7224685 0.501 rs6502765 chr17:3901814 A/G cg21851534 chr17:3907994 ZZEF1 0.37 6.29 0.33 9.89e-10 Type 2 diabetes; CRC cis rs7552404 0.924 rs2153126 chr1:76199345 C/G cg10523679 chr1:76189770 ACADM 0.93 14.38 0.62 1.01e-36 Blood metabolite levels;Acylcarnitine levels; CRC cis rs3796619 0.961 rs62294748 chr4:1082999 G/A cg27284194 chr4:1044797 NA 0.42 6.47 0.34 3.6e-10 Recombination rate (males); CRC cis rs79839061 0.610 rs2306252 chr4:892116 T/C cg07828340 chr4:882639 GAK 0.91 9.37 0.46 1.21e-18 Intelligence (multi-trait analysis); CRC cis rs116095464 0.558 rs28418643 chr5:240859 A/G cg22857025 chr5:266934 NA -1.25 -16.75 -0.68 5.7e-46 Breast cancer; CRC cis rs10751667 0.643 rs7396407 chr11:929374 A/T cg23136738 chr11:925521 AP2A2 -0.41 -6.8 -0.35 4.92e-11 Alzheimer's disease (late onset); CRC cis rs3850699 0.683 rs67646802 chr10:104303748 C/T cg04362960 chr10:104952993 NT5C2 0.47 6.08 0.32 3.27e-9 Prostate cancer; CRC cis rs2739330 0.734 rs2000467 chr22:24241533 C/T cg10150615 chr22:24372951 LOC391322 0.62 9.11 0.45 8.14e-18 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs9322193 0.884 rs7743823 chr6:150170880 A/G cg05861140 chr6:150128134 PCMT1 -0.43 -6.94 -0.36 2.04e-11 Lung cancer; CRC cis rs12802200 0.561 rs7937217 chr11:571967 T/C cg16486109 chr11:613632 IRF7 0.59 10.51 0.5 1.82e-22 Systemic lupus erythematosus; CRC cis rs7613875 0.620 rs7430334 chr3:50078221 T/C cg05623727 chr3:50126028 RBM5 -0.56 -9.67 -0.47 1.28e-19 Body mass index; CRC cis rs2976388 0.609 rs2376491 chr8:143790934 G/A cg22687807 chr8:143858763 LYNX1 0.49 8.78 0.44 8.82e-17 Urinary tract infection frequency; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg23307708 chr5:133561976 PPP2CA 0.38 6.5 0.34 2.98e-10 Liver disease severity in Alagille syndrome; CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg11310629 chr13:45991975 SLC25A30 -0.52 -6.42 -0.33 4.72e-10 Diisocyanate-induced asthma; CRC trans rs1814175 0.645 rs11040699 chr11:50023798 C/G cg03929089 chr4:120376271 NA -0.88 -15.84 -0.66 2.09e-42 Height; CRC cis rs412050 0.501 rs2876980 chr22:22106535 C/T cg17089214 chr22:22089827 YPEL1 -0.57 -6.11 -0.32 2.8e-9 Attention deficit hyperactivity disorder; CRC cis rs208520 0.690 rs12201219 chr6:66748862 A/T cg07460842 chr6:66804631 NA 1.06 14.78 0.63 2.91e-38 Exhaled nitric oxide output; CRC cis rs2243480 1.000 rs316312 chr7:65596491 T/G cg12463550 chr7:65579703 CRCP 0.69 6.4 0.33 5.42e-10 Diabetic kidney disease; CRC cis rs4253772 0.637 rs9627402 chr22:46702586 C/T cg03482458 chr22:46692211 CN5H6.4;GTSE1 0.51 6.27 0.33 1.15e-9 LDL cholesterol;Cholesterol, total; CRC trans rs1005277 0.602 rs2504142 chr10:38383793 C/T cg23533926 chr12:111358616 MYL2 -0.52 -7.85 -0.4 6.11e-14 Extrinsic epigenetic age acceleration; CRC cis rs13108904 0.535 rs1250101 chr4:1236111 G/A cg21620606 chr4:1342894 KIAA1530 -0.43 -6.63 -0.34 1.39e-10 Obesity-related traits; CRC cis rs589448 0.902 rs2603090 chr12:69777188 G/A cg22834771 chr12:69754056 YEATS4 -0.55 -8.66 -0.43 2.12e-16 Cerebrospinal fluid biomarker levels; CRC cis rs4903604 0.505 rs11623595 chr14:78037547 A/G cg18872420 chr14:78023429 SPTLC2 0.35 6.04 0.32 4.08e-9 Gut microbiome composition (winter); CRC cis rs911555 0.755 rs12432803 chr14:103930032 C/T cg12935359 chr14:103987150 CKB 0.55 8.91 0.44 3.49e-17 Intelligence (multi-trait analysis); CRC cis rs3126085 0.935 rs1496045 chr1:152184704 C/T cg09127314 chr1:152161683 NA 0.51 6.52 0.34 2.66e-10 Atopic dermatitis; CRC cis rs2204008 0.811 rs11520277 chr12:38359611 G/A cg26384229 chr12:38710491 ALG10B 0.68 9.77 0.47 5.8e-20 Bladder cancer; CRC cis rs9916302 0.706 rs6503500 chr17:37485925 C/T cg07936489 chr17:37558343 FBXL20 -0.91 -11.76 -0.54 6.85e-27 Glomerular filtration rate (creatinine); CRC cis rs7666738 0.830 rs11097608 chr4:99011693 T/C cg17366294 chr4:99064904 C4orf37 0.45 7.55 0.38 4.27e-13 Colonoscopy-negative controls vs population controls; CRC cis rs853679 0.527 rs853683 chr6:28295039 A/G cg15845792 chr6:28175446 NA 0.46 6.32 0.33 8.72e-10 Depression; CRC cis rs2297440 0.530 rs34533955 chr20:62233020 A/C cg16989086 chr20:62203971 PRIC285 0.51 6.41 0.33 5.08e-10 Glioma;Non-glioblastoma glioma;Glioblastoma; CRC cis rs10782582 0.532 rs12132503 chr1:76137762 C/G cg10523679 chr1:76189770 ACADM -0.4 -5.7 -0.3 2.63e-8 Daytime sleep phenotypes; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg17727855 chr9:108007124 SLC44A1 0.37 6.06 0.32 3.76e-9 Liver disease severity in Alagille syndrome; CRC cis rs4713118 0.868 rs7756968 chr6:27734954 C/G cg06470822 chr6:28175283 NA 0.83 9.33 0.46 1.6e-18 Parkinson's disease; CRC trans rs2727020 0.704 rs2988340 chr11:49176057 C/T cg11707556 chr5:10655725 ANKRD33B -0.43 -8.05 -0.41 1.49e-14 Coronary artery disease; CRC cis rs6693567 0.526 rs834239 chr1:150375458 C/A cg15654264 chr1:150340011 RPRD2 0.43 6.44 0.33 4.32e-10 Migraine; CRC cis rs12618769 0.625 rs17034241 chr2:99224998 C/G cg18455616 chr2:99124870 INPP4A 0.34 5.72 0.3 2.41e-8 Bipolar disorder; CRC trans rs7613875 0.641 rs6446194 chr3:50067298 T/A cg21665057 chr3:196295764 WDR53;FBXO45 -0.47 -7.1 -0.36 7.86e-12 Body mass index; CRC cis rs3806843 0.705 rs35614340 chr5:140043618 C/G cg19875535 chr5:140030758 IK -0.65 -10.88 -0.51 9.56e-24 Depressive symptoms (multi-trait analysis); CRC cis rs9818758 0.545 rs9853352 chr3:49813258 C/T cg00383909 chr3:49044727 WDR6 -1.17 -10.51 -0.5 1.87e-22 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; CRC cis rs17666538 0.585 rs1669733 chr8:606696 C/T cg02524346 chr8:600233 NA -0.86 -8.09 -0.41 1.15e-14 IgG glycosylation; CRC cis rs2067615 0.579 rs12424114 chr12:107144328 A/G cg13491945 chr12:107078410 RFX4 0.35 6.02 0.31 4.68e-9 Heart rate; CRC cis rs1552244 0.554 rs3732963 chr3:10048885 G/T cg18598329 chr3:10140678 FANCD2;C3orf24 -0.54 -7.67 -0.39 1.98e-13 Alzheimer's disease; CRC cis rs12500482 0.935 rs2239736 chr4:2438929 T/C cg08330972 chr4:2403930 ZFYVE28 -0.35 -5.66 -0.3 3.21e-8 Cognitive function; CRC cis rs6570726 0.935 rs376991 chr6:145828073 G/C cg23711669 chr6:146136114 FBXO30 0.68 12.16 0.56 2.33e-28 Lobe attachment (rater-scored or self-reported); CRC cis rs9372498 0.536 rs62422224 chr6:118941116 G/A cg15382696 chr6:118971807 C6orf204 0.56 6.86 0.35 3.34e-11 Diastolic blood pressure; CRC cis rs71403859 0.730 rs12931191 chr16:71621373 A/T cg08717414 chr16:71523259 ZNF19 1.05 9.96 0.48 1.29e-20 Post bronchodilator FEV1; CRC cis rs9517320 0.967 rs2274056 chr13:99134839 G/C cg20487152 chr13:99095054 FARP1 0.35 5.71 0.3 2.57e-8 Longevity; CRC cis rs72781680 0.821 rs116583405 chr2:24208221 T/C cg08917208 chr2:24149416 ATAD2B 0.57 6.8 0.35 4.96e-11 Lymphocyte counts; CRC cis rs4478858 0.684 rs3766289 chr1:31760128 G/A cg00250761 chr1:31883323 NA -0.43 -8.37 -0.42 1.68e-15 Alcohol dependence; CRC cis rs3003334 1 rs3003334 chr1:24199869 G/A cg09473613 chr1:24152604 HMGCL 0.35 5.76 0.3 1.97e-8 Eosinophil percentage of white cells;Eosinophil percentage of granulocytes; CRC trans rs629535 0.735 rs525610 chr8:70074535 A/G cg21567404 chr3:27674614 NA 0.92 15.32 0.65 2.38e-40 Dupuytren's disease; CRC cis rs617791 0.530 rs10791835 chr11:65750924 C/A cg09783858 chr11:65769428 EIF1AD;BANF1 0.49 7.36 0.38 1.5e-12 Breast cancer; CRC cis rs9435341 0.896 rs1623927 chr1:107596120 T/C cg09367891 chr1:107599246 PRMT6 -0.69 -10.08 -0.49 5.32e-21 Facial morphology (factor 21, depth of nasal alae); CRC trans rs2727020 0.729 rs7924782 chr11:49267249 A/G cg15704280 chr7:45808275 SEPT13 -0.87 -14.56 -0.63 2.12e-37 Coronary artery disease; CRC cis rs172166 0.637 rs1071893 chr6:28167635 G/C cg06470822 chr6:28175283 NA 0.87 13.71 0.6 3.75e-34 Cardiac Troponin-T levels; CRC cis rs854572 1.000 rs854572 chr7:94954696 C/G cg17330251 chr7:94953956 PON1 -0.81 -15.15 -0.64 1.05e-39 Paraoxonase activity; CRC cis rs6834538 0.501 rs2171278 chr4:113416438 G/A cg10021238 chr4:113569128 MIR367;LARP7 -0.36 -5.65 -0.3 3.55e-8 Free thyroxine concentration; CRC cis rs10504229 0.906 rs7842855 chr8:58167718 G/C cg22535103 chr8:58192502 C8orf71 -0.67 -10.75 -0.51 2.75e-23 Developmental language disorder (linguistic errors); CRC cis rs7727544 0.716 rs11955347 chr5:131567924 G/A cg02033258 chr5:131593261 PDLIM4 0.35 6.76 0.35 6.28e-11 Blood metabolite levels; CRC trans rs2055729 0.710 rs6981023 chr8:9746585 C/T cg08975724 chr8:8085496 FLJ10661 -0.5 -6.68 -0.35 1.04e-10 Multiple myeloma (hyperdiploidy); CRC trans rs7615952 0.546 rs2922171 chr3:125343193 C/T cg16558177 chr4:4109446 NA -0.56 -6.52 -0.34 2.73e-10 Blood pressure (smoking interaction); CRC cis rs4690686 0.538 rs10520346 chr4:177259088 C/G cg17059388 chr4:177262070 NA 0.38 5.71 0.3 2.52e-8 Essential tremor; CRC cis rs4713118 0.539 rs510987 chr6:27847517 G/A cg12273811 chr6:28175739 NA 0.55 7.67 0.39 1.92e-13 Parkinson's disease; CRC trans rs2243480 1.000 rs313809 chr7:65499983 G/A cg10756647 chr7:56101905 PSPH 0.79 8.21 0.41 5.15e-15 Diabetic kidney disease; CRC trans rs6600671 1.000 rs4844381 chr1:121184898 C/T cg00646200 chr1:148855367 NA 0.33 5.96 0.31 6.45e-9 Hip geometry; CRC cis rs4566357 0.576 rs6750845 chr2:227911037 T/G cg11843606 chr2:227700838 RHBDD1 -0.44 -6.85 -0.35 3.54e-11 Coronary artery disease; CRC cis rs1218582 0.741 rs6656494 chr1:154839799 A/G cg24250549 chr1:154909240 PMVK 0.62 10.55 0.5 1.36e-22 Prostate cancer; CRC cis rs832540 0.931 rs33319 chr5:56206675 C/A cg18230493 chr5:56204884 C5orf35 -0.39 -5.83 -0.31 1.34e-8 Coronary artery disease; CRC trans rs1997103 0.954 rs6953004 chr7:55411919 G/A cg20935933 chr6:143382018 AIG1 0.51 6.63 0.34 1.35e-10 QRS interval (sulfonylurea treatment interaction); CRC cis rs1572438 0.760 rs7766707 chr6:869501 C/T cg13447295 chr6:887704 NA -0.49 -7.11 -0.36 7.39e-12 Aging; CRC cis rs10540 1.000 rs61876340 chr11:495699 A/C cg03934478 chr11:495069 RNH1 0.69 7.73 0.39 1.28e-13 Body mass index; CRC cis rs9291683 0.679 rs2241483 chr4:10099831 A/G cg11266682 chr4:10021025 SLC2A9 -0.45 -9.04 -0.45 1.34e-17 Bone mineral density; CRC cis rs9768139 0.708 rs11771764 chr7:158119871 A/G cg06219351 chr7:158114137 PTPRN2 -0.52 -7.76 -0.39 1.1e-13 Calcium levels; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg00838250 chr3:186287958 TBCCD1;DNAJB11 0.48 6.25 0.33 1.27e-9 Thyroid stimulating hormone; CRC cis rs13256369 1.000 rs10110591 chr8:8576608 G/T cg08975724 chr8:8085496 FLJ10661 -0.46 -6.4 -0.33 5.3e-10 Obesity-related traits; CRC cis rs7103648 0.864 rs10769264 chr11:47423340 C/T cg20307385 chr11:47447363 PSMC3 0.99 18.14 0.71 1.87e-51 Diastolic blood pressure;Systolic blood pressure; CRC cis rs7959452 0.590 rs11177643 chr12:69785712 T/G cg20891283 chr12:69753455 YEATS4 0.91 17.34 0.69 2.78e-48 Blood protein levels; CRC cis rs4713118 0.869 rs9393851 chr6:27699581 A/T cg06470822 chr6:28175283 NA 0.71 10.07 0.49 5.85e-21 Parkinson's disease; CRC cis rs11203032 0.901 rs4073283 chr10:90958000 G/C cg16672925 chr10:90967113 CH25H 0.46 5.75 0.3 2.05e-8 Heart failure; CRC cis rs8031584 0.723 rs11632229 chr15:31179534 A/G cg08704250 chr15:31115839 NA 0.48 9.1 0.45 8.59e-18 Huntington's disease progression; CRC cis rs7914558 0.966 rs10748835 chr10:104660256 C/T cg04362960 chr10:104952993 NT5C2 0.56 8.48 0.42 7.99e-16 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs8072100 0.967 rs4289035 chr17:45707211 C/T cg25173405 chr17:45401733 C17orf57 -0.42 -6.56 -0.34 2.08e-10 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs208520 0.690 rs1563929 chr6:66702108 G/A cg07460842 chr6:66804631 NA 1.04 14.5 0.62 3.49e-37 Exhaled nitric oxide output; CRC cis rs17384381 0.634 rs11801146 chr1:85915374 C/T cg16011679 chr1:85725395 C1orf52 0.54 5.81 0.3 1.49e-8 Lobe attachment (rater-scored or self-reported); CRC trans rs10155879 0.505 rs12704265 chr7:86142678 A/G cg07538248 chr1:95699815 RWDD3 0.56 6.01 0.31 4.96e-9 Interleukin-4 levels; CRC cis rs796364 0.901 rs4673762 chr2:201065171 C/G cg25936922 chr2:200820526 C2orf60;C2orf47 0.61 6.56 0.34 2.03e-10 Schizophrenia; CRC cis rs6570726 0.791 rs446362 chr6:145878716 G/T cg13319975 chr6:146136371 FBXO30 -0.45 -6.59 -0.34 1.78e-10 Lobe attachment (rater-scored or self-reported); CRC cis rs34172651 0.583 rs200541 chr16:24733141 A/G cg00339695 chr16:24857497 SLC5A11 -0.4 -7.7 -0.39 1.62e-13 Intelligence (multi-trait analysis); CRC cis rs832540 0.618 rs41106 chr5:56145057 G/T cg18230493 chr5:56204884 C5orf35 -0.4 -5.67 -0.3 3.14e-8 Coronary artery disease; CRC cis rs832540 0.931 rs832536 chr5:56212595 C/T cg12311346 chr5:56204834 C5orf35 -0.53 -8.06 -0.41 1.47e-14 Coronary artery disease; CRC trans rs561341 1.000 rs8064843 chr17:30245744 A/G cg27661571 chr11:113659931 NA -0.48 -6.11 -0.32 2.87e-9 Hip circumference adjusted for BMI; CRC cis rs4253772 0.591 rs6007747 chr22:46657261 A/G cg24881330 chr22:46731750 TRMU 0.6 7.05 0.36 1.07e-11 LDL cholesterol;Cholesterol, total; CRC cis rs6424115 0.743 rs2229580 chr1:24201109 C/T cg10978503 chr1:24200527 CNR2 0.61 11.06 0.52 2.22e-24 Immature fraction of reticulocytes; CRC trans rs8002861 0.905 rs6561149 chr13:44456782 T/G cg17145862 chr1:211918768 LPGAT1 -0.73 -13.5 -0.6 2.45e-33 Leprosy; CRC cis rs1218582 0.772 rs6656435 chr1:154876869 G/A cg24250549 chr1:154909240 PMVK 0.65 11.29 0.53 3.28e-25 Prostate cancer; CRC cis rs40363 0.645 rs250627 chr16:3527050 G/A cg00484396 chr16:3507460 NAT15 0.53 7.86 0.4 5.39e-14 Tuberculosis; CRC cis rs992157 0.697 rs13384682 chr2:219069137 G/A cg00012203 chr2:219082015 ARPC2 0.62 10.39 0.5 4.69e-22 Colorectal cancer; CRC cis rs55788414 1.000 rs35667589 chr16:81180829 A/T cg06400318 chr16:81190750 PKD1L2 -0.66 -6.45 -0.33 4.06e-10 Left ventricular obstructive tract defect (maternal effect); CRC cis rs9381040 0.674 rs4711657 chr6:41162715 G/A cg03526776 chr6:41159608 TREML2 0.41 6.96 0.36 1.79e-11 Alzheimer's disease (late onset); CRC trans rs45509595 0.841 rs200485 chr6:27775697 G/C cg16898833 chr6:26189333 HIST1H4D 0.68 6.1 0.32 2.96e-9 Breast cancer; CRC cis rs7589728 0.844 rs77144652 chr2:88496684 G/A cg24977027 chr2:88469347 THNSL2 0.58 6.54 0.34 2.29e-10 Plasma clusterin levels; CRC cis rs10504229 0.683 rs11774697 chr8:58133119 G/A cg21724239 chr8:58056113 NA 0.74 9.29 0.46 2.1e-18 Developmental language disorder (linguistic errors); CRC cis rs1008375 1.000 rs2286771 chr4:17643848 G/A cg02297831 chr4:17616191 MED28 0.44 5.83 0.31 1.29e-8 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs883565 0.655 rs6599275 chr3:39050758 C/A cg01426195 chr3:39028469 NA -0.53 -8.56 -0.43 4.38e-16 Handedness; CRC cis rs1023500 0.573 rs133374 chr22:42465941 G/A cg15557168 chr22:42548783 NA -0.38 -6.64 -0.34 1.27e-10 Schizophrenia; CRC cis rs4713118 0.866 rs2179094 chr6:27741825 T/C cg15786705 chr6:28176104 NA 0.55 7.28 0.37 2.48e-12 Parkinson's disease; CRC cis rs6952808 1.000 rs6954521 chr7:1886865 C/A cg02951883 chr7:2050386 MAD1L1 -0.72 -11.39 -0.53 1.52e-25 Bipolar disorder and schizophrenia; CRC cis rs12451471 0.559 rs1042396 chr17:78084769 G/A cg18972013 chr17:78078605 GAA -0.41 -5.92 -0.31 8.23e-9 Plateletcrit;Mean corpuscular hemoglobin concentration; CRC cis rs889312 0.500 rs185219 chr5:56136492 A/G cg12311346 chr5:56204834 C5orf35 -0.47 -7.04 -0.36 1.15e-11 Breast cancer;Breast cancer (early onset); CRC cis rs9556958 0.708 rs4772092 chr13:99166614 A/G cg20750642 chr13:99100586 FARP1 0.4 6.16 0.32 2.09e-9 Educational attainment (years of education); CRC cis rs4604732 0.631 rs1106721 chr1:247624676 A/C cg12758973 chr1:247694275 LOC148824;OR2C3 0.42 6.19 0.32 1.78e-9 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg02757696 chr20:33104113 DYNLRB1 0.48 6.82 0.35 4.44e-11 Response to antipsychotic treatment; CRC cis rs6445967 1.000 rs6786088 chr3:58315075 T/C cg23715586 chr3:58305044 RPP14 0.37 6.21 0.32 1.56e-9 Platelet count; CRC cis rs11785400 1.000 rs3735999 chr8:143746069 T/C cg24634471 chr8:143751801 JRK 0.53 7.55 0.38 4.42e-13 Schizophrenia; CRC cis rs9811920 0.809 rs796976 chr3:99621002 G/A cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G 0.4 5.7 0.3 2.6e-8 Axial length; CRC cis rs728616 0.867 rs61860034 chr10:81931848 C/T cg11900509 chr10:81946545 ANXA11 -0.72 -7.23 -0.37 3.46e-12 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs11148252 0.538 rs2274202 chr13:52722798 C/A cg00495681 chr13:53174319 NA 0.64 9.69 0.47 1.1e-19 Lewy body disease; CRC cis rs2032447 0.933 rs4401650 chr6:26035208 G/A cg03264133 chr6:25882463 NA -0.5 -6.88 -0.35 3.12e-11 Intelligence (multi-trait analysis); CRC cis rs4713118 0.869 rs9283883 chr6:27715470 T/A cg12273811 chr6:28175739 NA 0.56 7.9 0.4 4.35e-14 Parkinson's disease; CRC cis rs4930103 0.935 rs4930098 chr11:2020955 G/C cg06197492 chr11:2016605 H19 0.41 6.42 0.33 4.72e-10 DNA methylation (parent-of-origin);DNA methylation (variation); CRC cis rs17253792 0.822 rs76472022 chr14:56053660 C/T cg01858014 chr14:56050164 KTN1 -0.88 -7.07 -0.36 9.07e-12 Putamen volume; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg09672230 chr9:128024003 GAPVD1 0.47 6.51 0.34 2.73e-10 Response to antipsychotic treatment; CRC cis rs7493 1.000 rs17166875 chr7:95041271 C/T cg07404485 chr7:94953653 PON1 -0.45 -5.92 -0.31 7.97e-9 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs9399135 0.636 rs4646871 chr6:135265617 A/G cg24558204 chr6:135376177 HBS1L -0.52 -8.28 -0.42 3.22e-15 Red blood cell count; CRC cis rs7659604 0.537 rs6815973 chr4:122663430 A/T cg06713675 chr4:122721982 EXOSC9 0.43 6.32 0.33 8.57e-10 Type 2 diabetes; CRC cis rs736408 0.527 rs2336147 chr3:52626443 T/C cg11645453 chr3:52864694 ITIH4 0.33 5.97 0.31 6.18e-9 Bipolar disorder; CRC cis rs11958404 0.932 rs72816549 chr5:157417957 G/A cg05962755 chr5:157440814 NA 0.83 11.22 0.53 5.81e-25 IgG glycosylation; CRC cis rs523522 0.923 rs2235217 chr12:120884328 C/T cg12219531 chr12:120966889 COQ5 0.71 9.34 0.46 1.49e-18 High light scatter reticulocyte count; CRC cis rs425277 0.606 rs12082939 chr1:2078922 C/T cg21194808 chr1:2205498 SKI 0.39 6.07 0.32 3.59e-9 Height; CRC cis rs6951245 1.000 rs28528096 chr7:1070912 G/C cg18402987 chr7:1209562 NA 0.64 6.77 0.35 6.03e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC trans rs800082 0.516 rs1178892 chr3:144238173 A/G cg24215973 chr2:240111563 HDAC4 0.45 6.22 0.32 1.48e-9 Smoking behavior; CRC trans rs561341 0.941 rs550213 chr17:30317518 C/G cg27661571 chr11:113659931 NA -0.76 -9.53 -0.47 3.57e-19 Hip circumference adjusted for BMI; CRC cis rs2502731 0.539 rs3003609 chr9:130984755 A/G cg13642260 chr9:130955380 CIZ1 -0.44 -7.04 -0.36 1.11e-11 Attention deficit hyperactivity disorder; CRC cis rs3857536 0.813 rs6931701 chr6:66940905 T/C cg07460842 chr6:66804631 NA -0.43 -5.81 -0.3 1.48e-8 Blood trace element (Cu levels); CRC cis rs1707322 0.681 rs12048866 chr1:46117492 T/G cg03146154 chr1:46216737 IPP 0.66 9.64 0.47 1.55e-19 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs1949733 0.598 rs55765509 chr4:8532732 T/A cg13073564 chr4:8508604 NA 0.41 6.06 0.32 3.76e-9 Response to antineoplastic agents; CRC cis rs7487075 0.619 rs7959731 chr12:46839657 A/C cg22049899 chr12:47219821 SLC38A4 -0.31 -5.74 -0.3 2.21e-8 Itch intensity from mosquito bite; CRC cis rs939584 0.935 rs7567710 chr2:645372 T/G cg03610516 chr2:642275 NA 0.42 5.88 0.31 9.94e-9 Body mass index; CRC cis rs9649213 0.593 rs11760930 chr7:97915789 G/A cg00277769 chr7:97922759 BAIAP2L1 -0.61 -10.64 -0.51 6.63e-23 Prostate cancer (SNP x SNP interaction); CRC cis rs9814567 0.964 rs12492930 chr3:134222722 A/G cg06541857 chr3:134203789 ANAPC13;CEP63 -0.41 -6.22 -0.32 1.48e-9 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs7208859 0.623 rs7208441 chr17:29143863 C/T cg13385521 chr17:29058706 SUZ12P 0.74 8.44 0.42 9.97e-16 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs6586163 1.000 rs7072828 chr10:90754953 T/G cg13456138 chr10:90753195 FAS -0.43 -6.6 -0.34 1.65e-10 Chronic lymphocytic leukemia; CRC cis rs1538970 0.961 rs7543428 chr1:45839643 A/G cg05343316 chr1:45956843 TESK2 0.68 9.11 0.45 8.27e-18 Platelet count; CRC cis rs4862750 0.914 rs9998558 chr4:187874691 A/G cg06074448 chr4:187884817 NA -0.57 -10.63 -0.51 7.22e-23 Lobe attachment (rater-scored or self-reported); CRC cis rs6701037 0.681 rs1057239 chr1:175130204 G/A cg00321850 chr1:175162397 KIAA0040 -0.41 -6.79 -0.35 5.29e-11 Alcohol dependence; CRC cis rs853679 0.517 rs9368558 chr6:28133306 A/G cg03623178 chr6:28175578 NA 0.98 12.66 0.57 3.31e-30 Depression; CRC cis rs924607 0.898 rs905193 chr5:635095 T/C cg09021430 chr5:549028 NA -0.51 -8.45 -0.42 9.25e-16 Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia; CRC trans rs113835537 0.627 rs4630309 chr11:66333072 A/C cg04774096 chr14:31676207 HECTD1 0.6 6.19 0.32 1.82e-9 Airway imaging phenotypes; CRC cis rs28374715 0.528 rs7181982 chr15:41623020 C/G cg18705301 chr15:41695430 NDUFAF1 -1.09 -18.62 -0.72 2.35e-53 Ulcerative colitis; CRC cis rs1538970 1.000 rs7417107 chr1:45831915 G/C cg05343316 chr1:45956843 TESK2 0.63 8.69 0.43 1.69e-16 Platelet count; CRC cis rs9462027 0.606 rs3777752 chr6:34772212 A/T cg07306190 chr6:34760872 UHRF1BP1 -0.34 -6.07 -0.32 3.47e-9 Systemic lupus erythematosus; CRC cis rs4363385 0.934 rs6667418 chr1:152969685 A/G cg25856811 chr1:152973957 SPRR3 -0.22 -5.67 -0.3 3.21e-8 Inflammatory skin disease; CRC cis rs79349575 0.783 rs2112617 chr17:46977125 G/A cg00947319 chr17:47005597 UBE2Z -0.34 -5.84 -0.31 1.22e-8 Type 2 diabetes; CRC cis rs881375 1.000 rs6478484 chr9:123652380 T/C cg14255062 chr9:123606675 PSMD5;LOC253039 0.43 6.25 0.33 1.28e-9 Rheumatoid arthritis; CRC cis rs10911232 0.507 rs10911230 chr1:183051118 A/C ch.1.3577855R chr1:183094577 LAMC1 0.82 14.22 0.62 4.28e-36 Hypertriglyceridemia; CRC cis rs2336384 1.000 rs61776516 chr1:12047028 T/C cg13216073 chr1:12042593 MFN2 0.49 7.12 0.37 6.82e-12 Platelet count; CRC cis rs9443645 0.901 rs4565265 chr6:79741958 A/G cg09184832 chr6:79620586 NA -0.51 -9.3 -0.46 2.01e-18 Intelligence (multi-trait analysis); CRC cis rs904251 0.828 rs1757174 chr6:37486695 G/A cg25019722 chr6:37503610 NA -0.5 -9.29 -0.46 2.17e-18 Cognitive performance; CRC cis rs853679 0.517 rs9368558 chr6:28133306 A/G cg21251018 chr6:28226885 NKAPL 0.48 6.17 0.32 2.02e-9 Depression; CRC cis rs992157 0.560 rs6738394 chr2:219110625 G/A cg04880052 chr2:219191631 PNKD -0.43 -6.94 -0.36 2.09e-11 Colorectal cancer; CRC cis rs10504229 0.871 rs10504227 chr8:58162005 G/A cg02290350 chr8:58132656 NA -0.44 -6.58 -0.34 1.91e-10 Developmental language disorder (linguistic errors); CRC cis rs11676348 0.846 rs11677534 chr2:219007060 T/C cg00012203 chr2:219082015 ARPC2 -0.44 -6.59 -0.34 1.71e-10 Ulcerative colitis; CRC cis rs28386778 0.897 rs9906247 chr17:61857314 T/C cg07362569 chr17:61921086 SMARCD2 0.37 5.64 0.3 3.64e-8 Prudent dietary pattern; CRC cis rs9611565 0.559 rs5758428 chr22:42106216 G/A cg06481639 chr22:41940642 POLR3H 0.53 5.99 0.31 5.62e-9 Vitiligo; CRC trans rs6703335 0.870 rs10803142 chr1:243598234 A/G cg03328750 chr5:142150401 ARHGAP26 0.43 6.02 0.31 4.62e-9 Schizophrenia;Schizophrenia, schizoaffective disorder or bipolar disorder; CRC trans rs1455244 0.700 rs7229302 chr18:11508904 G/T cg14478806 chr15:80351979 ZFAND6 0.42 6.49 0.34 3.13e-10 Schizophrenia; CRC cis rs17270561 0.779 rs1165200 chr6:25875212 C/T cg17691542 chr6:26056736 HIST1H1C -0.64 -8.03 -0.4 1.76e-14 Iron status biomarkers; CRC cis rs6952808 0.825 rs4236277 chr7:1942270 C/T cg02951883 chr7:2050386 MAD1L1 -0.7 -11.32 -0.53 2.52e-25 Bipolar disorder and schizophrenia; CRC cis rs8180040 0.966 rs3736177 chr3:47451411 C/T cg02527881 chr3:46936655 PTH1R 0.39 7.0 0.36 1.47e-11 Colorectal cancer; CRC cis rs4642101 0.662 rs57411588 chr3:12820384 C/G cg24848339 chr3:12840334 CAND2 0.34 6.35 0.33 6.96e-10 QRS complex (12-leadsum); CRC cis rs875971 1.000 rs4718344 chr7:65874381 C/A cg11764359 chr7:65958608 NA 0.61 9.95 0.48 1.41e-20 Aortic root size; CRC cis rs796364 0.901 rs13030683 chr2:201061535 C/T cg25936922 chr2:200820526 C2orf60;C2orf47 0.54 6.07 0.32 3.45e-9 Schizophrenia; CRC cis rs10504229 0.679 rs7813252 chr8:58136389 C/G cg22535103 chr8:58192502 C8orf71 -0.68 -9.07 -0.45 1.11e-17 Developmental language disorder (linguistic errors); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg20650861 chr18:72264895 LOC400657 0.43 6.42 0.33 4.7e-10 Response to antipsychotic treatment; CRC trans rs225245 0.531 rs321609 chr17:33880676 G/T cg19694781 chr19:47549865 TMEM160 -0.53 -8.0 -0.4 2.1e-14 Reticulocyte count;Reticulocyte fraction of red cells;High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells; CRC cis rs910316 1.000 rs7156328 chr14:75532941 T/C cg03030879 chr14:75389066 RPS6KL1 -0.49 -7.65 -0.39 2.17e-13 Height; CRC cis rs10512697 0.655 rs71594952 chr5:3457718 T/C cg19473799 chr5:3511975 NA -0.83 -6.34 -0.33 7.66e-10 Immune response to smallpox vaccine (IL-6); CRC cis rs56104184 0.775 rs55981795 chr19:49401952 A/C cg21252483 chr19:49399788 TULP2 -0.42 -6.45 -0.34 3.99e-10 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; CRC cis rs763121 0.651 rs738249 chr22:39037979 T/C cg06022373 chr22:39101656 GTPBP1 0.79 12.13 0.56 3.12e-28 Menopause (age at onset); CRC cis rs748404 0.660 rs548704 chr15:43791706 A/C cg02155558 chr15:43621948 ADAL;LCMT2 0.52 7.47 0.38 7.38e-13 Lung cancer; CRC cis rs67311347 1.000 rs9842564 chr3:40405810 A/G cg09455208 chr3:40491958 NA -0.37 -7.59 -0.39 3.26e-13 Renal cell carcinoma; CRC cis rs11608355 0.521 rs6606704 chr12:109814036 T/C cg19025524 chr12:109796872 NA -0.57 -9.18 -0.45 4.95e-18 Neuroticism; CRC cis rs9527 0.615 rs12248123 chr10:104735366 A/G cg15744005 chr10:104629667 AS3MT -0.31 -6.2 -0.32 1.7e-9 Arsenic metabolism; CRC cis rs904251 0.772 rs756202 chr6:37460350 C/A cg25019722 chr6:37503610 NA -0.41 -6.82 -0.35 4.47e-11 Cognitive performance; CRC cis rs4363385 0.782 rs310126 chr1:153019416 A/C cg25856811 chr1:152973957 SPRR3 -0.27 -7.32 -0.37 1.95e-12 Inflammatory skin disease; CRC cis rs4713118 0.869 rs6456802 chr6:27698355 A/G cg19041857 chr6:27730383 NA -0.41 -6.0 -0.31 5.3300000000000004e-09 Parkinson's disease; CRC cis rs910316 0.967 rs1071989 chr14:75564659 G/T cg03030879 chr14:75389066 RPS6KL1 -0.46 -7.25 -0.37 2.99e-12 Height; CRC cis rs116095464 0.558 rs56043030 chr5:220917 A/G cg22496380 chr5:211416 CCDC127 -0.83 -9.55 -0.47 3.03e-19 Breast cancer; CRC cis rs7945718 0.591 rs10831892 chr11:12676272 T/A cg25843174 chr11:12811716 TEAD1 0.39 7.07 0.36 9.43e-12 Educational attainment (years of education); CRC cis rs250677 0.958 rs36067 chr5:148417553 T/G cg23229984 chr5:148520753 ABLIM3 0.5 6.82 0.35 4.28e-11 Breast cancer; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg21887597 chr15:83419354 NA 0.44 6.36 0.33 6.72e-10 Response to antipsychotic treatment; CRC cis rs8063761 0.640 rs4785760 chr16:90051438 G/A cg08547343 chr16:90038815 CENPBD1;AFG3L1 0.7 11.26 0.53 4.18e-25 Squamous cell carcinoma; CRC cis rs3790645 1.000 rs282177 chr1:26899125 C/T cg17456097 chr1:26900765 RPS6KA1 0.43 6.48 0.34 3.25e-10 Glucose homeostasis traits; CRC cis rs60843830 1.000 rs62114497 chr2:214837 G/A cg00108164 chr2:264199 ACP1;SH3YL1 0.61 9.19 0.45 4.41e-18 Spherical equivalent (joint analysis main effects and education interaction); CRC cis rs6504622 0.517 rs11656362 chr17:45036255 C/G cg16759221 chr17:45003025 GOSR2 -0.72 -11.37 -0.53 1.8e-25 Orofacial clefts; CRC cis rs17376456 0.825 rs10075217 chr5:93176774 C/G cg21475434 chr5:93447410 FAM172A 0.68 6.75 0.35 6.71e-11 Diabetic retinopathy; CRC cis rs1552244 0.882 rs13063098 chr3:10009919 G/A cg00166722 chr3:10149974 C3orf24 0.63 8.29 0.42 2.84e-15 Alzheimer's disease; CRC trans rs2243480 1.000 rs56016656 chr7:65383481 C/T cg10756647 chr7:56101905 PSPH 0.7 7.33 0.37 1.85e-12 Diabetic kidney disease; CRC cis rs6951245 1.000 rs11761941 chr7:1097183 G/A cg21664854 chr7:1097933 C7orf50;GPR146 0.77 8.8 0.44 7.85e-17 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs6589219 0.954 rs3802841 chr11:111171672 G/T cg25129781 chr11:111156908 C11orf53 -0.31 -5.77 -0.3 1.82e-8 Colorectal cancer; CRC cis rs2228479 0.557 rs62054639 chr16:89821489 C/T cg06656553 chr16:89960601 TCF25 -0.7 -5.76 -0.3 1.93e-8 Skin colour saturation; CRC cis rs7264396 0.790 rs2425097 chr20:34308926 C/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.64 -10.89 -0.51 8.94e-24 Total cholesterol levels; CRC cis rs3741404 0.895 rs1860368 chr11:63994692 T/C cg04317338 chr11:64019027 PLCB3 -0.41 -5.96 -0.31 6.47e-9 Platelet count; CRC cis rs1799949 0.965 rs8176323 chr17:41195711 G/C cg05368731 chr17:41323189 NBR1 0.68 10.35 0.5 6.24e-22 Menopause (age at onset); CRC cis rs10504229 0.683 rs7463453 chr8:58112053 A/G cg05313129 chr8:58192883 C8orf71 -0.42 -5.85 -0.31 1.16e-8 Developmental language disorder (linguistic errors); CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg17496447 chr4:144435124 SMARCA5 0.49 7.0 0.36 1.48e-11 Anxiety disorder; CRC cis rs3791556 0.661 rs3791539 chr2:240102327 C/T cg03281426 chr2:240109471 HDAC4 0.61 7.93 0.4 3.43e-14 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs4523957 0.928 rs4790072 chr17:2173497 A/G cg16513277 chr17:2031491 SMG6 -0.55 -9.44 -0.46 6.96e-19 Autism spectrum disorder or schizophrenia;Schizophrenia; CRC cis rs910316 1.000 rs7147118 chr14:75610170 G/C cg03030879 chr14:75389066 RPS6KL1 -0.46 -7.13 -0.37 6.26e-12 Height; CRC cis rs992157 0.835 rs12987219 chr2:219144149 G/A cg00012203 chr2:219082015 ARPC2 -0.47 -7.11 -0.37 7.1e-12 Colorectal cancer; CRC cis rs12971120 0.947 rs8083001 chr18:72165058 A/G cg26446133 chr18:72167187 CNDP2 -0.78 -15.51 -0.65 4.14e-41 Refractive error; CRC cis rs7772486 0.686 rs9403746 chr6:146103768 C/A cg13319975 chr6:146136371 FBXO30 0.46 6.95 0.36 1.96e-11 Lobe attachment (rater-scored or self-reported); CRC cis rs9814567 1.000 rs7648990 chr3:134244390 T/G cg06109529 chr3:134205091 CEP63;ANAPC13 -0.81 -12.19 -0.56 1.92e-28 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs9311474 1.000 rs7629072 chr3:52305633 C/T cg18099408 chr3:52552593 STAB1 -0.47 -8.1 -0.41 1.1e-14 Electroencephalogram traits; CRC cis rs11168351 0.927 rs7971880 chr12:48391055 C/T cg24011408 chr12:48396354 COL2A1 0.41 5.87 0.31 1.04e-8 Bipolar disorder and schizophrenia; CRC cis rs7666738 0.830 rs6834014 chr4:98951431 G/A cg05340658 chr4:99064831 C4orf37 0.61 9.54 0.47 3.45e-19 Colonoscopy-negative controls vs population controls; CRC cis rs7584330 0.554 rs56881028 chr2:238446678 C/G cg16989719 chr2:238392110 NA -0.36 -5.71 -0.3 2.57e-8 Prostate cancer; CRC cis rs9814567 1.000 rs9819532 chr3:134288644 G/C cg06109529 chr3:134205091 CEP63;ANAPC13 -0.82 -12.35 -0.56 4.64e-29 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC trans rs1455244 0.700 rs7229302 chr18:11508904 G/T cg25628243 chr3:196295415 WDR53;FBXO45 0.41 6.28 0.33 1.1e-9 Schizophrenia; CRC cis rs1008375 0.966 rs1860599 chr4:17638900 T/C cg16339924 chr4:17578868 LAP3 0.58 7.73 0.39 1.35e-13 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs9372498 0.536 rs9489407 chr6:118792337 A/T cg07617317 chr6:118971624 C6orf204 -0.47 -5.93 -0.31 7.7e-9 Diastolic blood pressure; CRC trans rs7821565 0.904 rs67153919 chr8:52165801 C/G cg09187163 chr7:72721838 NSUN5 -0.41 -5.98 -0.31 5.79e-9 Tuberculosis; CRC cis rs1448094 0.791 rs10863110 chr12:86328523 T/C cg00310523 chr12:86230176 RASSF9 0.43 7.26 0.37 2.88e-12 Major depressive disorder; CRC cis rs9443645 0.808 rs9361484 chr6:79758218 C/A cg11833968 chr6:79620685 NA -0.36 -6.13 -0.32 2.5e-9 Intelligence (multi-trait analysis); CRC cis rs11711311 0.911 rs9817327 chr3:113478500 A/G cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.51 -6.92 -0.36 2.41e-11 IgG glycosylation; CRC cis rs9611565 0.659 rs116959331 chr22:41932774 A/G cg06634786 chr22:41940651 POLR3H -0.66 -7.66 -0.39 2.04e-13 Vitiligo; CRC cis rs12188164 0.965 rs72717435 chr5:448202 G/A cg16322479 chr5:444228 EXOC3;C5orf55 0.5 8.06 0.41 1.43e-14 Cystic fibrosis severity; CRC cis rs58649573 0.509 rs4838093 chr9:126788876 G/T cg14112217 chr9:126806003 NA 0.41 6.05 0.32 3.99e-9 Post-traumatic stress disorder; CRC cis rs2745967 0.818 rs11579568 chr1:208130627 A/C cg09788693 chr1:208063733 CD34 0.39 5.86 0.31 1.13e-8 Resting heart rate; CRC cis rs61996546 0.595 rs2315906 chr15:26867573 A/G cg15066197 chr15:26874202 GABRB3 -0.39 -5.99 -0.31 5.37e-9 Response to methotrexate in juvenile idiopathic arthritis; CRC cis rs1865760 0.865 rs9467645 chr6:25955176 G/C cg16482183 chr6:26056742 HIST1H1C 0.54 7.94 0.4 3.26e-14 Height; CRC trans rs5756813 0.635 rs11089856 chr22:38205784 A/C cg19894588 chr14:64061835 NA -0.62 -8.41 -0.42 1.3e-15 Optic cup area;Vertical cup-disc ratio; CRC cis rs832540 0.618 rs2548663 chr5:56172778 G/A cg24531977 chr5:56204891 C5orf35 -0.53 -7.83 -0.4 6.8e-14 Coronary artery disease; CRC cis rs67478160 0.619 rs55824307 chr14:104271207 C/T cg01849466 chr14:104193079 ZFYVE21 -0.47 -8.2 -0.41 5.63e-15 Schizophrenia; CRC cis rs35306767 0.903 rs11812523 chr10:915638 C/T cg26597838 chr10:835615 NA 0.98 12.1 0.55 3.94e-28 Eosinophil percentage of granulocytes; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg16924120 chr12:118814149 SUDS3 0.47 6.75 0.35 6.56e-11 Response to antipsychotic treatment; CRC cis rs2180341 0.781 rs6913350 chr6:127570560 C/T cg24812749 chr6:127587940 RNF146 0.73 10.63 0.51 6.87e-23 Breast cancer; CRC cis rs7726839 0.540 rs11739847 chr5:609661 G/A cg14541582 chr5:601475 NA -0.36 -7.29 -0.37 2.3e-12 Obesity-related traits; CRC trans rs1814175 0.817 rs7946556 chr11:49944874 G/A cg15704280 chr7:45808275 SEPT13 -0.97 -18.78 -0.72 5.61e-54 Height; CRC cis rs9322193 0.884 rs9371201 chr6:150145001 C/T cg00933542 chr6:150070202 PCMT1 0.3 5.79 0.3 1.69e-8 Lung cancer; CRC cis rs9733 0.596 rs12085275 chr1:150650265 T/C cg10589385 chr1:150898437 SETDB1 0.28 5.98 0.31 5.86e-9 Tonsillectomy; CRC cis rs28386778 0.863 rs3760252 chr17:61852186 G/C cg23090583 chr17:61904693 PSMC5;FTSJ3 1.05 20.36 0.75 3.43e-60 Prudent dietary pattern; CRC cis rs853679 0.598 rs9380054 chr6:28067537 G/A cg03623178 chr6:28175578 NA 0.95 12.46 0.57 1.93e-29 Depression; CRC trans rs1005277 0.579 rs1780139 chr10:38503018 C/T cg23533926 chr12:111358616 MYL2 -0.56 -8.67 -0.43 1.97e-16 Extrinsic epigenetic age acceleration; CRC cis rs523522 0.962 rs3742052 chr12:120966921 A/G cg12219531 chr12:120966889 COQ5 0.69 9.28 0.46 2.36e-18 High light scatter reticulocyte count; CRC cis rs2530545 0.671 rs2067575 chr7:34666534 A/G cg14401837 chr7:34697493 NPSR1 -0.52 -5.81 -0.31 1.44e-8 IgG glycosylation; CRC cis rs10504229 0.906 rs7003276 chr8:58173089 A/T cg02290350 chr8:58132656 NA -0.44 -6.39 -0.33 5.52e-10 Developmental language disorder (linguistic errors); CRC cis rs2739330 0.760 rs1002286 chr22:24257337 A/G cg18538332 chr22:24372958 LOC391322 0.7 11.41 0.53 1.22e-25 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs6502050 0.835 rs4789678 chr17:80101078 C/T cg22110888 chr17:80059540 CCDC57 0.41 6.52 0.34 2.71e-10 Life satisfaction; CRC cis rs9648716 1.000 rs57248447 chr7:140573495 G/A cg10747023 chr7:140774559 NA 0.45 5.82 0.31 1.36e-8 Type 2 diabetes; CRC cis rs4819052 0.918 rs2330013 chr21:46658662 G/T cg19498844 chr21:46707878 POFUT2;LOC642852 0.84 11.07 0.52 2.02e-24 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs853679 0.517 rs9348797 chr6:28137533 G/C cg12963246 chr6:28129442 ZNF389 0.49 5.7 0.3 2.71e-8 Depression; CRC cis rs12497850 0.864 rs7431857 chr3:48900347 G/A cg07636037 chr3:49044803 WDR6 1.04 18.72 0.72 9.87e-54 Parkinson's disease; CRC cis rs727505 0.583 rs17147421 chr7:124383948 C/T cg23710748 chr7:124431027 NA -0.61 -9.75 -0.47 6.51e-20 Lewy body disease; CRC cis rs9303280 0.806 rs9904624 chr17:38036586 A/G cg11212589 chr17:38028394 ZPBP2 0.43 8.03 0.4 1.71e-14 Self-reported allergy; CRC cis rs7772486 0.727 rs4896843 chr6:146063451 T/C cg05347473 chr6:146136440 FBXO30 -0.4 -5.96 -0.31 6.55e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs921968 0.565 rs4674328 chr2:219593203 T/C cg02176678 chr2:219576539 TTLL4 -0.42 -6.66 -0.34 1.16e-10 Mean corpuscular hemoglobin concentration; CRC cis rs1862618 0.525 rs2662019 chr5:56263104 A/G cg03609598 chr5:56110824 MAP3K1 0.55 6.56 0.34 2.13e-10 Initial pursuit acceleration; CRC cis rs35306767 0.903 rs11253462 chr10:889323 T/G cg20503657 chr10:835505 NA 0.88 11.07 0.52 2.05e-24 Eosinophil percentage of granulocytes; CRC cis rs9796 0.558 rs7166905 chr15:41514876 G/C cg18705301 chr15:41695430 NDUFAF1 -0.4 -6.62 -0.34 1.44e-10 Menopause (age at onset); CRC trans rs1864729 1.000 rs2439702 chr8:98272647 C/T cg08679828 chr8:102218111 ZNF706 -0.62 -7.46 -0.38 7.69e-13 Estradiol plasma levels (breast cancer); CRC cis rs7131987 0.801 rs6487804 chr12:29454934 G/A cg09582351 chr12:29534625 ERGIC2 -0.35 -7.61 -0.39 2.86e-13 QT interval; CRC cis rs3741404 0.825 rs60452247 chr11:63981507 G/A cg05016508 chr11:63871570 FLRT1;MACROD1 0.48 7.27 0.37 2.7e-12 Platelet count; CRC trans rs7615952 0.866 rs11922276 chr3:125631326 G/T cg00769240 chr8:12517080 NA -0.58 -6.84 -0.35 3.99e-11 Blood pressure (smoking interaction); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg15087520 chr3:187871600 LPP 0.44 6.06 0.32 3.82e-9 Response to antipsychotic treatment; CRC cis rs9322193 0.886 rs9485408 chr6:149940024 T/C cg13206674 chr6:150067644 NUP43 0.64 9.69 0.47 1.04e-19 Lung cancer; CRC cis rs9549367 0.713 rs3024743 chr13:113821430 C/T cg18105134 chr13:113819100 PROZ -0.87 -13.4 -0.59 5.64e-33 Platelet distribution width; CRC cis rs977987 0.872 rs4243111 chr16:75320827 C/T cg03315344 chr16:75512273 CHST6 0.52 8.75 0.43 1.14e-16 Dupuytren's disease; CRC cis rs6570726 0.846 rs973856 chr6:145781916 C/T cg23711669 chr6:146136114 FBXO30 -0.66 -11.7 -0.54 1.17e-26 Lobe attachment (rater-scored or self-reported); CRC cis rs1552244 0.810 rs35711405 chr3:10116939 C/T cg08888203 chr3:10149979 C3orf24 0.73 10.16 0.49 2.86e-21 Alzheimer's disease; CRC cis rs9660992 0.573 rs12144980 chr1:205185104 C/T cg21643547 chr1:205240462 TMCC2 -0.37 -5.95 -0.31 6.98e-9 Mean corpuscular volume;Mean platelet volume; CRC trans rs2243480 1.000 rs35283677 chr7:65359233 C/T cg10756647 chr7:56101905 PSPH 0.69 7.1 0.36 7.8e-12 Diabetic kidney disease; CRC cis rs62402013 1 rs62402013 chr6:26915000 A/G cg05192639 chr6:26864778 GUSBL1 0.34 6.17 0.32 2.05e-9 Schizophrenia; CRC cis rs447 1.000 rs10261415 chr7:83760881 G/T cg22846510 chr7:83753280 SEMA3A -0.58 -7.73 -0.39 1.29e-13 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs6687430 0.526 rs6688558 chr1:10611403 A/G cg17425144 chr1:10567563 PEX14 0.45 9.04 0.45 1.42e-17 Hand grip strength; CRC cis rs9527 0.571 rs12219246 chr10:104613355 A/G cg15744005 chr10:104629667 AS3MT -0.38 -7.81 -0.4 7.67e-14 Arsenic metabolism; CRC cis rs2739330 0.791 rs4822458 chr22:24265659 C/T cg04234412 chr22:24373322 LOC391322 -0.83 -14.61 -0.63 1.32e-37 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs10493773 0.532 rs1889919 chr1:86180034 A/G cg00734567 chr1:86172782 ZNHIT6 -0.38 -6.0 -0.31 5.1e-9 Urate levels in overweight individuals; CRC cis rs4713675 0.565 rs3818530 chr6:33661222 C/G cg14003231 chr6:33640908 ITPR3 0.51 8.37 0.42 1.73e-15 Plateletcrit; CRC cis rs10512697 0.803 rs11747645 chr5:3576820 A/G cg19473799 chr5:3511975 NA 0.71 5.71 0.3 2.53e-8 Immune response to smallpox vaccine (IL-6); CRC cis rs28386778 0.863 rs2584637 chr17:61942952 T/C cg25654072 chr17:61904446 PSMC5;FTSJ3 0.71 10.93 0.52 6.15e-24 Prudent dietary pattern; CRC cis rs947211 0.950 rs885224 chr1:205753097 A/G cg14893161 chr1:205819251 PM20D1 0.45 6.31 0.33 8.79e-10 Parkinson's disease; CRC cis rs4889855 0.556 rs4890040 chr17:78518408 G/A cg16591659 chr17:78472290 NA 0.37 5.67 0.3 3.14e-8 Fractional excretion of uric acid; CRC cis rs10504229 1.000 rs66731170 chr8:58187895 C/G cg22535103 chr8:58192502 C8orf71 -0.82 -12.27 -0.56 9.63e-29 Developmental language disorder (linguistic errors); CRC cis rs3902035 0.964 rs17349301 chr6:119002581 A/T cg01339444 chr6:118972232 C6orf204 -0.46 -5.86 -0.31 1.11e-8 QT interval; CRC cis rs6582630 0.638 rs7963994 chr12:38555535 G/A cg13010199 chr12:38710504 ALG10B -0.42 -6.14 -0.32 2.34e-9 Drug-induced liver injury (flucloxacillin); CRC cis rs1348850 0.915 rs10930798 chr2:178446141 G/A cg22681709 chr2:178499509 PDE11A -0.33 -6.21 -0.32 1.62e-9 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs10822145 1 rs10822145 chr10:64934548 C/T cg08743896 chr10:65200160 JMJD1C -0.39 -5.63 -0.3 3.87e-8 Triglycerides; CRC cis rs6066835 0.572 rs6125413 chr20:47257145 G/A cg18078177 chr20:47281410 PREX1 0.78 5.96 0.31 6.37e-9 Multiple myeloma; CRC cis rs2153535 0.580 rs5001322 chr6:8451608 A/G cg07606381 chr6:8435919 SLC35B3 0.68 10.85 0.51 1.2e-23 Motion sickness; CRC trans rs7824557 0.507 rs7010590 chr8:11062882 C/T cg16141378 chr3:129829833 LOC729375 -0.41 -5.98 -0.31 5.71e-9 Retinal vascular caliber; CRC cis rs939584 0.935 rs7571957 chr2:646803 T/C cg03610516 chr2:642275 NA 0.41 5.74 0.3 2.18e-8 Body mass index; CRC cis rs4713675 0.546 rs9348925 chr6:33710696 C/T cg14003231 chr6:33640908 ITPR3 0.45 7.47 0.38 7.28e-13 Plateletcrit; CRC cis rs12497850 0.931 rs9311430 chr3:48845251 C/T cg20833759 chr3:49053208 WDR6;DALRD3 0.53 9.22 0.45 3.73e-18 Parkinson's disease; CRC trans rs2243480 1.000 rs34136756 chr7:65381256 A/G cg10756647 chr7:56101905 PSPH 0.73 7.94 0.4 3.18e-14 Diabetic kidney disease; CRC cis rs863345 0.604 rs10908666 chr1:158500098 G/T cg12129480 chr1:158549410 OR10X1 -0.3 -6.24 -0.33 1.35e-9 Pneumococcal bacteremia; CRC cis rs2421770 0.530 rs4755396 chr11:35370624 G/A cg13971030 chr11:35366721 SLC1A2 -0.37 -6.42 -0.33 4.85e-10 Staphylococcus aureus nasal carriage (persistent); CRC cis rs9447004 0.583 rs28360541 chr6:74432427 T/G cg03006477 chr6:74432658 CD109 0.38 6.73 0.35 7.77e-11 Blood protein levels;Calcium levels; CRC cis rs644799 0.965 rs598876 chr11:95560853 A/G cg25478527 chr11:95522999 CEP57;FAM76B 0.52 7.86 0.4 5.6e-14 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs875971 0.830 rs6967708 chr7:65657313 A/T cg12463550 chr7:65579703 CRCP -0.54 -7.69 -0.39 1.73e-13 Aortic root size; CRC cis rs9649213 0.593 rs3801255 chr7:98000929 C/T cg24562669 chr7:97807699 LMTK2 0.44 7.27 0.37 2.71e-12 Prostate cancer (SNP x SNP interaction); CRC cis rs7043114 0.525 rs1053441 chr9:95147840 T/A cg14631576 chr9:95140430 CENPP -0.3 -5.63 -0.3 3.78e-8 Height; CRC cis rs6502050 0.835 rs9646397 chr17:80083534 G/A cg13198984 chr17:80129470 CCDC57 -0.48 -8.56 -0.43 4.49e-16 Life satisfaction; CRC trans rs800082 0.516 rs1726545 chr3:144244807 T/A cg24215973 chr2:240111563 HDAC4 0.46 6.54 0.34 2.3e-10 Smoking behavior; CRC cis rs4481233 0.528 rs115776655 chr4:10381329 C/T cg00071950 chr4:10020882 SLC2A9 -0.51 -6.55 -0.34 2.17e-10 Metabolic traits; CRC cis rs1223397 0.589 rs364493 chr6:13297020 C/T cg20827128 chr6:13274284 PHACTR1 -0.45 -6.54 -0.34 2.35e-10 Blood pressure; CRC trans rs11148252 0.904 rs9568732 chr13:52993412 A/G cg18335740 chr13:41363409 SLC25A15 -0.63 -10.36 -0.5 5.97e-22 Lewy body disease; CRC cis rs1832871 0.683 rs9459852 chr6:158687250 T/G cg07165851 chr6:158734300 TULP4 0.61 7.72 0.39 1.41e-13 Height; CRC trans rs57221529 0.608 rs11749927 chr5:668842 C/T cg11887960 chr12:57824829 NA 0.52 6.41 0.33 5.08e-10 Lung disease severity in cystic fibrosis; CRC cis rs3760982 0.585 rs10422108 chr19:44294868 C/T cg12072164 chr19:44306565 LYPD5 0.35 5.63 0.3 3.91e-8 Breast cancer (estrogen-receptor negative);Breast cancer; CRC cis rs12541635 1.000 rs1540420 chr8:107088426 C/T cg10147462 chr8:107024639 NA -0.37 -6.3 -0.33 9.62e-10 Age of smoking initiation; CRC cis rs9393692 0.846 rs7771202 chr6:26279907 A/G cg00631329 chr6:26305371 NA -0.69 -13.61 -0.6 8.87e-34 Educational attainment; CRC cis rs6674176 0.597 rs3762422 chr1:44400532 T/A cg12908607 chr1:44402522 ARTN -0.64 -12.01 -0.55 8.56e-28 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Cognitive ability; CRC cis rs1065852 0.526 rs12166549 chr22:42410419 T/C cg22189786 chr22:42395067 WBP2NL 0.43 6.29 0.33 1.01e-9 Response to serotonin reuptake inhibitors in major depressive disorder (plasma drug and metabolite levels); CRC cis rs1003719 0.788 rs1155785 chr21:38447939 A/G cg10648535 chr21:38446584 PIGP;TTC3 0.53 7.53 0.38 4.82e-13 Eye color traits; CRC cis rs11098499 0.909 rs17046118 chr4:120387496 T/G cg24375607 chr4:120327624 NA 0.5 7.72 0.39 1.4e-13 Corneal astigmatism; CRC cis rs11098499 0.754 rs1546503 chr4:120241167 T/C cg09307838 chr4:120376055 NA 0.62 9.5 0.46 4.59e-19 Corneal astigmatism; CRC cis rs6120849 0.707 rs6120799 chr20:33614955 T/C cg08999081 chr20:33150536 PIGU 0.45 5.79 0.3 1.66e-8 Protein C levels; CRC cis rs12819124 0.502 rs10875718 chr12:48411102 G/T cg24011408 chr12:48396354 COL2A1 0.39 5.66 0.3 3.27e-8 Glycated hemoglobin levels; CRC cis rs2380220 0.510 rs9387562 chr6:96057006 G/T cg04719120 chr6:96025338 MANEA 0.74 9.21 0.45 3.83e-18 Behavioural disinhibition (generation interaction); CRC trans rs1005277 0.579 rs2474594 chr10:38426661 G/C cg11292332 chr7:45801988 SEPT13 -0.35 -6.25 -0.33 1.3e-9 Extrinsic epigenetic age acceleration; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg10958397 chr10:127511832 BCCIP;UROS 0.48 7.04 0.36 1.16e-11 Intelligence (multi-trait analysis); CRC trans rs11098499 0.697 rs4373140 chr4:120307698 A/G cg25214090 chr10:38739885 LOC399744 0.62 9.74 0.47 7.35e-20 Corneal astigmatism; CRC cis rs1005277 0.579 rs2749616 chr10:38510993 A/T cg25427524 chr10:38739819 LOC399744 -0.77 -13.58 -0.6 1.19e-33 Extrinsic epigenetic age acceleration; CRC cis rs644799 0.562 rs669973 chr11:95571839 A/G cg25622487 chr11:95524042 FAM76B;CEP57 0.58 8.79 0.44 8.66e-17 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs28374715 0.580 rs8030228 chr15:41636867 A/G cg18705301 chr15:41695430 NDUFAF1 -0.94 -15.83 -0.66 2.32e-42 Ulcerative colitis; CRC cis rs7552404 0.731 rs5745445 chr1:76344332 G/A cg10523679 chr1:76189770 ACADM 0.73 8.74 0.43 1.18e-16 Blood metabolite levels;Acylcarnitine levels; CRC cis rs9291683 0.530 rs4697698 chr4:9942577 C/T cg11266682 chr4:10021025 SLC2A9 0.51 10.37 0.5 5.49e-22 Bone mineral density; CRC trans rs7267979 1.000 rs1046073 chr20:25281333 G/A cg17903999 chr18:56338584 MALT1 -0.42 -6.99 -0.36 1.52e-11 Liver enzyme levels (alkaline phosphatase); CRC cis rs10463316 0.894 rs7703283 chr5:150764904 C/T cg03212797 chr5:150827313 SLC36A1 -0.5 -7.78 -0.39 9.23e-14 Metabolite levels (Pyroglutamine); CRC cis rs6547741 0.967 rs4665995 chr2:27813827 T/G cg27432699 chr2:27873401 GPN1 0.77 13.64 0.6 7.11e-34 Oral cavity cancer; CRC cis rs950776 0.714 rs615470 chr15:78885988 T/C cg06917634 chr15:78832804 PSMA4 -0.5 -7.54 -0.38 4.57e-13 Sudden cardiac arrest; CRC cis rs17253792 0.822 rs77555779 chr14:56078430 A/G cg24579896 chr14:56047964 C14orf33;KTN1 0.71 5.69 0.3 2.81e-8 Putamen volume; CRC cis rs10992471 0.729 rs13284038 chr9:95555488 A/G cg14631576 chr9:95140430 CENPP -0.34 -6.14 -0.32 2.32e-9 Visceral adipose tissue/subcutaneous adipose tissue ratio; CRC cis rs3785574 0.962 rs35448669 chr17:61938923 G/A cg06873352 chr17:61820015 STRADA 0.46 7.12 0.37 6.81e-12 Height; CRC cis rs6540559 0.673 rs7550857 chr1:209956542 C/A cg23283495 chr1:209979779 IRF6 0.5 6.95 0.36 2.02e-11 Cleft lip with or without cleft palate; CRC cis rs8060686 0.641 rs7192187 chr16:68132109 T/C cg26727032 chr16:67993705 SLC12A4 -0.6 -8.11 -0.41 1.04e-14 HDL cholesterol;Metabolic syndrome; CRC cis rs875971 0.929 rs778692 chr7:65872449 A/G cg12463550 chr7:65579703 CRCP 0.48 6.96 0.36 1.89e-11 Aortic root size; CRC trans rs7821565 0.904 rs67575264 chr8:52165828 C/T cg09187163 chr7:72721838 NSUN5 -0.41 -5.98 -0.31 5.79e-9 Tuberculosis; CRC cis rs6429082 0.749 rs291362 chr1:235686690 T/A cg26050004 chr1:235667680 B3GALNT2 0.63 9.55 0.47 3.01e-19 Adiposity; CRC cis rs4494114 0.967 rs6660891 chr1:39319009 C/T cg25970120 chr1:39325951 RRAGC -0.44 -5.89 -0.31 9.29e-9 Blood protein levels; CRC cis rs8062405 1.000 rs55830740 chr16:28847149 G/C cg16576597 chr16:28551801 NUPR1 0.48 6.9 0.36 2.65e-11 Cognitive ability (multi-trait analysis);Cognitive ability; CRC trans rs61931739 0.534 rs4365131 chr12:34053308 T/C cg26384229 chr12:38710491 ALG10B 0.51 6.97 0.36 1.77e-11 Morning vs. evening chronotype; CRC cis rs10924970 0.776 rs72758049 chr1:235465045 G/T cg26050004 chr1:235667680 B3GALNT2 0.39 5.89 0.31 9.32e-9 Asthma; CRC cis rs769267 0.965 rs1469712 chr19:19528821 C/A cg03709012 chr19:19516395 GATAD2A 0.72 11.2 0.53 6.93e-25 Tonsillectomy; CRC cis rs35306767 0.953 rs11253521 chr10:976416 G/C cg20503657 chr10:835505 NA 0.74 9.49 0.46 4.73e-19 Eosinophil percentage of granulocytes; CRC cis rs523522 0.962 rs11065145 chr12:120947419 A/G cg12219531 chr12:120966889 COQ5 0.69 9.28 0.46 2.36e-18 High light scatter reticulocyte count; CRC cis rs4713118 0.513 rs1225591 chr6:28148752 G/A cg10876282 chr6:28092338 ZSCAN16 0.5 6.67 0.35 1.05e-10 Parkinson's disease; CRC cis rs9399135 0.844 rs13209789 chr6:135367916 A/G cg22676075 chr6:135203613 NA 0.39 6.08 0.32 3.42e-9 Red blood cell count; CRC cis rs1223397 0.938 rs17767967 chr6:13282067 C/T cg00460589 chr6:13274354 PHACTR1 0.49 5.95 0.31 6.68e-9 Blood pressure; CRC trans rs12458462 0.787 rs56006341 chr18:77439844 G/T cg09220050 chr20:48770642 TMEM189;TMEM189-UBE2V1 -0.43 -6.33 -0.33 8.04e-10 Monocyte count; CRC cis rs2576037 0.526 rs4890699 chr18:44541029 T/C cg07643061 chr18:44555308 TCEB3C;TCEB3CL;KATNAL2 -0.34 -5.66 -0.3 3.3e-8 Personality dimensions; CRC cis rs12701220 0.500 rs6463224 chr7:1140418 C/A cg23978390 chr7:1156363 C7orf50 0.58 6.91 0.36 2.45e-11 Bronchopulmonary dysplasia; CRC cis rs2652834 1.000 rs2729781 chr15:63404265 T/A cg05507819 chr15:63340323 TPM1 0.44 5.61 0.3 4.19e-8 HDL cholesterol; CRC cis rs9467711 0.591 rs13195279 chr6:25919431 T/A cg08501292 chr6:25962987 TRIM38 1.08 9.74 0.47 7.5e-20 Autism spectrum disorder or schizophrenia; CRC cis rs3736485 0.609 rs11631725 chr15:51969474 A/G cg08986416 chr15:51914746 DMXL2 -0.39 -5.66 -0.3 3.31e-8 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs2832191 0.740 rs2853830 chr21:30416824 A/G cg24692254 chr21:30365293 RNF160 0.84 15.86 0.66 1.71e-42 Dental caries; CRC cis rs4908760 0.965 rs12080583 chr1:8524877 G/A cg20416874 chr1:8611966 RERE -0.43 -6.09 -0.32 3.2e-9 Vitiligo; CRC cis rs7613875 0.620 rs34312088 chr3:50032133 C/T cg24110177 chr3:50126178 RBM5 -0.53 -8.04 -0.41 1.61e-14 Body mass index; CRC cis rs8072100 0.607 rs9894594 chr17:45461383 A/G cg25173405 chr17:45401733 C17orf57 -0.46 -6.97 -0.36 1.75e-11 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC trans rs2303319 0.504 rs62187656 chr2:162487699 A/G cg06896663 chr8:82754093 SNX16 -0.69 -5.96 -0.31 6.54e-9 Cognitive function; CRC cis rs798554 0.634 rs1182180 chr7:2873279 G/T cg13628971 chr7:2884303 GNA12 0.4 6.27 0.33 1.13e-9 Height; CRC cis rs875971 0.543 rs801191 chr7:66032955 G/A cg11764359 chr7:65958608 NA -0.5 -7.74 -0.39 1.23e-13 Aortic root size; CRC cis rs3796352 0.764 rs11714902 chr3:53101544 G/C cg06204229 chr3:52865917 ITIH4 0.48 5.68 0.3 2.93e-8 Immune reponse to smallpox (secreted IL-2); CRC cis rs910316 0.673 rs2012627 chr14:75443103 C/T cg03030879 chr14:75389066 RPS6KL1 -0.43 -6.64 -0.34 1.28e-10 Height; CRC cis rs2342371 0.756 rs28712197 chr3:196107214 T/C cg15048948 chr3:196158458 UBXN7 0.51 6.26 0.33 1.18e-9 Fat distribution (HIV); CRC cis rs9308731 0.563 rs6760053 chr2:111932997 C/G cg04202892 chr2:111875749 ACOXL 0.4 6.26 0.33 1.22e-9 Chronic lymphocytic leukemia; CRC cis rs17826219 0.568 rs9907834 chr17:29154013 G/A cg13385521 chr17:29058706 SUZ12P 0.65 7.4 0.38 1.15e-12 Body mass index; CRC cis rs2354432 0.556 rs11239964 chr1:146753902 G/C cg25205988 chr1:146714368 CHD1L -1.23 -9.95 -0.48 1.45e-20 Mitochondrial DNA levels; CRC cis rs7551222 0.752 rs4328119 chr1:204564986 C/T cg07972458 chr1:204535000 NA 0.37 5.72 0.3 2.36e-8 Schizophrenia; CRC cis rs394563 0.901 rs448874 chr6:149796967 C/T cg07828024 chr6:149772892 ZC3H12D -0.47 -8.17 -0.41 6.78e-15 Dupuytren's disease; CRC cis rs116095464 0.558 rs13356367 chr5:242395 C/T cg22496380 chr5:211416 CCDC127 -0.91 -10.41 -0.5 4.13e-22 Breast cancer; CRC cis rs17376456 0.877 rs10476596 chr5:93367074 C/T cg09848695 chr5:92956644 FAM172A;MIR2277 -0.64 -5.84 -0.31 1.28e-8 Diabetic retinopathy; CRC cis rs8062405 0.755 rs62034350 chr16:28562256 A/G cg16576597 chr16:28551801 NUPR1 0.56 8.26 0.41 3.67e-15 Cognitive ability (multi-trait analysis);Cognitive ability; CRC cis rs1018836 0.544 rs2063978 chr8:91459525 C/T cg16814680 chr8:91681699 NA -0.46 -6.87 -0.35 3.22e-11 Ejection fraction in Tripanosoma cruzi seropositivity; CRC cis rs35110281 0.806 rs1454649 chr21:45032982 C/T cg01579765 chr21:45077557 HSF2BP -0.39 -7.56 -0.38 4.02e-13 Mean corpuscular volume; CRC cis rs13256369 0.802 rs12680019 chr8:8561698 A/G cg00074818 chr8:8560427 CLDN23 0.4 7.27 0.37 2.69e-12 Obesity-related traits; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg00286986 chr8:124085360 WDR67 0.42 5.96 0.31 6.39e-9 Response to antipsychotic treatment; CRC cis rs2982552 0.967 rs3020300 chr6:152058844 T/A cg22157087 chr6:152012887 ESR1 0.39 6.12 0.32 2.66e-9 Bone properties (heel); CRC cis rs2842992 0.830 rs2842966 chr6:160141592 C/T cg11366901 chr6:160182831 ACAT2 0.9 12.27 0.56 9.28e-29 Age-related macular degeneration (geographic atrophy); CRC cis rs9488822 0.676 rs12202641 chr6:116314634 A/G cg15226275 chr6:116381976 FRK -0.28 -7.96 -0.4 2.8e-14 Cholesterol, total;LDL cholesterol; CRC cis rs524023 1.000 rs10897518 chr11:64360705 A/G cg14139581 chr11:64358342 SLC22A12 0.39 6.28 0.33 1.07e-9 Urate levels in obese individuals; CRC trans rs7615952 0.515 rs7630575 chr3:125682330 A/G cg07211511 chr3:129823064 LOC729375 -0.73 -9.83 -0.48 3.7e-20 Blood pressure (smoking interaction); CRC cis rs7119 0.689 rs12901765 chr15:77819103 C/A cg10437265 chr15:77819839 NA 0.69 12.75 0.57 1.6e-30 Type 2 diabetes; CRC cis rs950169 1.000 rs1911155 chr15:84787635 A/G cg24253500 chr15:84953950 NA 0.38 6.4 0.33 5.33e-10 Schizophrenia; CRC cis rs7777484 0.500 rs757787 chr7:2836355 G/A cg13628971 chr7:2884303 GNA12 0.37 5.67 0.3 3.14e-8 Height; CRC cis rs35110281 0.774 rs1378080 chr21:45011315 T/A cg04455712 chr21:45112962 RRP1B 0.4 7.7 0.39 1.64e-13 Mean corpuscular volume; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg07582382 chr10:15001273 MEIG1 0.43 6.14 0.32 2.34e-9 Intelligence (multi-trait analysis); CRC cis rs208520 1.000 rs12191403 chr6:66978137 C/T cg07460842 chr6:66804631 NA 0.91 11.17 0.52 8.75e-25 Exhaled nitric oxide output; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg24167897 chr15:63796719 USP3 0.4 6.1 0.32 2.94e-9 Intelligence (multi-trait analysis); CRC cis rs7259376 0.936 rs58170323 chr19:22539115 T/C cg02657401 chr19:22469223 NA -0.34 -7.62 -0.39 2.73e-13 Menopause (age at onset); CRC cis rs56104184 0.668 rs73063523 chr19:49408943 T/C cg21252483 chr19:49399788 TULP2 -0.43 -6.8 -0.35 5.03e-11 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; CRC cis rs2625529 0.689 rs12898728 chr15:72112853 C/T cg16672083 chr15:72433130 SENP8 -0.45 -6.71 -0.35 8.58e-11 Red blood cell count; CRC cis rs1552244 0.744 rs6763366 chr3:10033544 T/C cg10729496 chr3:10149963 C3orf24 0.49 6.34 0.33 7.69e-10 Alzheimer's disease; CRC trans rs1973993 0.651 rs60776572 chr1:96960121 C/T cg10631902 chr5:14652156 NA -0.42 -7.03 -0.36 1.18e-11 Weight; CRC cis rs1552244 0.882 rs112621205 chr3:10017916 G/A cg00166722 chr3:10149974 C3orf24 0.61 7.92 0.4 3.81e-14 Alzheimer's disease; CRC cis rs6662572 0.703 rs55641506 chr1:46580708 G/A cg03123370 chr1:45965343 CCDC163P;MMACHC 0.47 6.3 0.33 9.58e-10 Blood protein levels; CRC cis rs72781680 0.848 rs56021814 chr2:24073437 T/A cg08917208 chr2:24149416 ATAD2B 0.93 9.54 0.47 3.27e-19 Lymphocyte counts; CRC cis rs7833790 0.963 rs10958046 chr8:82729210 A/G cg27398817 chr8:82754497 SNX16 -0.55 -6.65 -0.34 1.24e-10 Diastolic blood pressure; CRC cis rs4919694 0.572 rs12261294 chr10:104934952 C/T cg04362960 chr10:104952993 NT5C2 0.89 9.19 0.45 4.58e-18 Arsenic metabolism; CRC cis rs6951245 0.554 rs4724294 chr7:1139695 G/A cg18297960 chr7:1142765 C7orf50 -0.44 -6.12 -0.32 2.61e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs1580019 0.563 rs764483 chr7:32578150 A/T cg14728415 chr7:32535168 LSM5;AVL9 0.44 6.2 0.32 1.65e-9 Cognitive ability; CRC cis rs9916302 0.904 rs634365 chr17:37436966 C/T cg03013999 chr17:37608204 MED1 0.45 6.97 0.36 1.69e-11 Glomerular filtration rate (creatinine); CRC cis rs11122272 0.733 rs2749700 chr1:231522734 A/G cg06096015 chr1:231504339 EGLN1 0.38 5.81 0.31 1.47e-8 Hemoglobin concentration; CRC cis rs2072499 0.966 rs2253677 chr1:156171296 C/G cg25208724 chr1:156163844 SLC25A44 -1.11 -28.25 -0.84 5.42e-90 Testicular germ cell tumor; CRC cis rs9457247 0.967 rs2149083 chr6:167370971 G/C cg23791538 chr6:167370224 RNASET2 0.39 5.98 0.31 5.67e-9 Crohn's disease; CRC cis rs870825 0.616 rs6834156 chr4:185639903 G/C cg04058563 chr4:185651563 MLF1IP 0.73 9.7 0.47 9.94e-20 Blood protein levels; CRC cis rs6743376 0.556 rs2251876 chr2:113818727 A/G cg24553058 chr2:113831203 IL1F10 0.39 6.56 0.34 2.15e-10 Inflammatory biomarkers; CRC cis rs853679 0.517 rs1904841 chr6:28108085 C/T cg03623178 chr6:28175578 NA 0.96 12.41 0.56 2.85e-29 Depression; CRC cis rs28386778 0.897 rs2665831 chr17:61912392 C/T cg00280220 chr17:61926910 NA 0.34 5.61 0.3 4.22e-8 Prudent dietary pattern; CRC trans rs11098499 0.954 rs7656252 chr4:120404268 T/C cg25214090 chr10:38739885 LOC399744 0.65 10.37 0.5 5.64e-22 Corneal astigmatism; CRC cis rs698833 0.892 rs786418 chr2:44688413 C/T cg04920474 chr2:44395004 PPM1B 0.41 5.98 0.31 5.86e-9 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; CRC trans rs877282 0.898 rs12359731 chr10:759497 A/G cg22713356 chr15:30763199 NA 1.22 15.04 0.64 2.8e-39 Uric acid levels; CRC cis rs9916302 0.861 rs3889368 chr17:37683231 C/T cg00129232 chr17:37814104 STARD3 -0.55 -8.13 -0.41 9.03e-15 Glomerular filtration rate (creatinine); CRC cis rs7300001 0.596 rs11064924 chr12:110510301 G/T cg12870014 chr12:110450643 ANKRD13A 0.86 8.88 0.44 4.53e-17 Headache; CRC cis rs4237845 0.513 rs7134797 chr12:58263852 C/T cg00677455 chr12:58241039 CTDSP2 0.78 11.51 0.54 5.56e-26 Intelligence (multi-trait analysis); CRC cis rs7827545 0.545 rs6998092 chr8:135557449 A/G cg17885191 chr8:135476712 NA 0.65 7.55 0.38 4.28e-13 Hypertension (SNP x SNP interaction); CRC cis rs10193935 0.901 rs72798529 chr2:42537471 C/T cg27598129 chr2:42591480 NA -0.7 -8.1 -0.41 1.05e-14 Colonoscopy-negative controls vs population controls; CRC cis rs3135063 0.504 rs78139882 chr4:3287361 C/T cg08817983 chr4:3391423 RGS12 -0.45 -6.44 -0.33 4.27e-10 Blood protein levels; CRC cis rs10504229 0.683 rs34859456 chr8:58117722 A/C cg21724239 chr8:58056113 NA 0.49 6.81 0.35 4.75e-11 Developmental language disorder (linguistic errors); CRC cis rs10504229 0.683 rs17194529 chr8:58105647 A/G cg11062466 chr8:58055876 NA 0.56 7.02 0.36 1.25e-11 Developmental language disorder (linguistic errors); CRC cis rs1552244 0.832 rs3732968 chr3:10013273 A/G cg13047869 chr3:10149882 C3orf24 0.53 7.15 0.37 5.54e-12 Alzheimer's disease; CRC cis rs7666738 1.000 rs13144055 chr4:99026849 A/G cg17366294 chr4:99064904 C4orf37 0.45 7.24 0.37 3.17e-12 Colonoscopy-negative controls vs population controls; CRC trans rs10982213 0.830 rs2274163 chr9:117188714 C/T cg18899730 chr10:74057705 NA 0.38 6.02 0.31 4.58e-9 Interleukin-6 levels; CRC cis rs282587 0.597 rs438116 chr13:113392149 G/C cg04656015 chr13:113407548 ATP11A 0.61 7.47 0.38 7.3e-13 Glycated hemoglobin levels; CRC cis rs1800469 1.000 rs1982072 chr19:41864509 T/A cg09537434 chr19:41945824 ATP5SL -0.52 -6.48 -0.34 3.39e-10 Colorectal cancer; CRC cis rs2302190 0.941 rs6503865 chr17:56549672 A/C cg12560992 chr17:57184187 TRIM37 0.5 5.93 0.31 7.77e-9 Vitamin D levels; CRC cis rs7605827 0.930 rs11893253 chr2:15606618 A/G cg19274914 chr2:15703543 NA 0.38 5.8 0.3 1.57e-8 Educational attainment (years of education); CRC cis rs10392 0.516 rs4141892 chr20:37590758 T/C cg27552599 chr20:37590471 DHX35 0.38 6.05 0.32 3.94e-9 Alcohol dependence or chronic alcoholic pancreatitis or alcohol-related liver cirrhosis; CRC cis rs10504229 0.639 rs35527749 chr8:58128077 G/T cg05313129 chr8:58192883 C8orf71 -0.5 -5.89 -0.31 9.49e-9 Developmental language disorder (linguistic errors); CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg09272629 chr14:78174293 ALKBH1;C14orf156 -0.42 -6.29 -0.33 9.99e-10 Myopia (pathological); CRC cis rs6860806 0.507 rs156322 chr5:131653925 C/T cg20512303 chr5:131592959 PDLIM4 0.4 6.72 0.35 7.95e-11 Breast cancer; CRC cis rs875971 0.895 rs4718349 chr7:65909011 C/G cg18912574 chr7:65842487 NCRNA00174 0.36 6.1 0.32 2.97e-9 Aortic root size; CRC cis rs7103648 0.966 rs1534576 chr11:47419663 A/C cg20307385 chr11:47447363 PSMC3 -0.98 -17.96 -0.7 9.63e-51 Diastolic blood pressure;Systolic blood pressure; CRC cis rs8067545 0.750 rs9897653 chr17:19987924 G/A cg13482628 chr17:19912719 NA 0.48 7.71 0.39 1.49e-13 Schizophrenia; CRC cis rs3772130 1.000 rs11719458 chr3:121382005 C/T cg20356878 chr3:121714668 ILDR1 0.5 7.69 0.39 1.74e-13 Cognitive performance; CRC trans rs12478296 0.792 rs6740738 chr2:243007368 A/C cg06834434 chr14:75079333 LTBP2 0.55 6.82 0.35 4.44e-11 Obesity-related traits; CRC cis rs3008870 1.000 rs2815348 chr1:67472165 G/C cg08660285 chr1:67390436 MIER1;WDR78 1.01 14.69 0.63 6.35e-38 Lymphocyte percentage of white cells; CRC cis rs9487051 0.676 rs4406271 chr6:109598213 G/A cg12927641 chr6:109611667 NA -0.36 -6.44 -0.33 4.15e-10 Reticulocyte fraction of red cells; CRC cis rs2658782 1.000 rs2605583 chr11:93164957 T/A cg21115391 chr11:93143810 CCDC67 -0.39 -5.68 -0.3 2.94e-8 Pulmonary function decline; CRC cis rs9463078 0.715 rs9296455 chr6:45236781 G/A cg25276700 chr6:44698697 NA -0.24 -5.88 -0.31 9.9e-9 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; CRC cis rs2976388 0.590 rs13254346 chr8:143823863 G/C cg22687807 chr8:143858763 LYNX1 -0.45 -7.44 -0.38 9.07e-13 Urinary tract infection frequency; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg05621273 chr16:81070150 ATMIN 0.48 6.2 0.32 1.71e-9 Thyroid stimulating hormone; CRC cis rs709400 1.000 rs57218990 chr14:104128007 T/A cg24130564 chr14:104152367 KLC1 -0.44 -6.52 -0.34 2.68e-10 Body mass index; CRC cis rs501120 0.584 rs11238935 chr10:44714402 C/T cg09554077 chr10:44749378 NA 0.65 7.29 0.37 2.37e-12 Coronary artery disease;Coronary heart disease; CRC cis rs6951245 1.000 rs78158942 chr7:1090440 G/T cg04025307 chr7:1156635 C7orf50 0.62 6.48 0.34 3.35e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs711830 0.965 rs2072590 chr2:177042633 A/C cg13092806 chr2:177043255 NA 0.73 9.28 0.46 2.36e-18 Serous invasive ovarian cancer;Epithelial ovarian cancer;Invasive epithelial ovarian cancer;Mucinous ovarian carcinoma;Low-grade serous and serous borderline ovarian cancer;Serous borderline ovarian cancer;High-grade serous ovarian cancer; CRC cis rs7333181 0.649 rs2027428 chr13:112228836 G/A cg27543320 chr13:112200689 NA -0.56 -9.48 -0.46 5.43e-19 Menopause (age at onset); CRC cis rs1552244 0.935 rs7652190 chr3:10105150 G/A cg13047869 chr3:10149882 C3orf24 0.59 7.95 0.4 2.94e-14 Alzheimer's disease; CRC cis rs3849570 0.555 rs9968070 chr3:82010368 G/A cg07356753 chr3:81810745 GBE1 -0.49 -6.79 -0.35 5.15e-11 Waist circumference;Body mass index; CRC cis rs826838 0.967 rs826856 chr12:39115434 G/A cg13010199 chr12:38710504 ALG10B -0.39 -5.68 -0.3 2.94e-8 Heart rate; CRC cis rs4074493 1.000 rs11122198 chr1:231171139 G/A cg22172038 chr1:231176991 FAM89A 0.37 6.32 0.33 8.68e-10 Carotid plaque burden (smoking interaction); CRC trans rs6956675 0.915 rs4717501 chr7:62652936 C/T cg01314568 chr7:57830625 NA -0.62 -8.63 -0.43 2.7e-16 Obesity-related traits; CRC cis rs8177253 0.930 rs12595 chr3:133496553 T/C cg01448562 chr3:133502909 NA -0.54 -9.16 -0.45 5.6e-18 Iron status biomarkers; CRC cis rs853679 0.517 rs4711164 chr6:28115156 C/T cg02683197 chr6:28174875 NA 0.87 10.73 0.51 3.25e-23 Depression; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg20204401 chr17:78010341 CCDC40;TBC1D16 0.49 6.93 0.36 2.18e-11 Anxiety disorder; CRC trans rs9341835 0.608 rs2800017 chr6:64158077 C/T cg13657004 chr13:50234944 EBPL 0.38 6.54 0.34 2.42e-10 Schizophrenia; CRC cis rs9368481 0.729 rs9379948 chr6:26944783 T/G cg12292205 chr6:26970375 C6orf41 0.66 10.84 0.51 1.27e-23 Autism spectrum disorder or schizophrenia; CRC cis rs7552404 0.924 rs1303169 chr1:76195041 T/C cg22875332 chr1:76189707 ACADM 0.69 10.66 0.51 5.37e-23 Blood metabolite levels;Acylcarnitine levels; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg25336731 chr2:70520884 SNRPG 0.39 6.32 0.33 8.74e-10 Liver disease severity in Alagille syndrome; CRC trans rs9329221 0.527 rs7833781 chr8:10333477 A/G cg08975724 chr8:8085496 FLJ10661 0.4 6.01 0.31 4.93e-9 Neuroticism; CRC trans rs2727020 0.729 rs34647977 chr11:49195543 G/A cg15704280 chr7:45808275 SEPT13 -0.86 -14.85 -0.63 1.62e-38 Coronary artery disease; CRC cis rs2180341 0.814 rs6914131 chr6:127737489 T/C cg27446573 chr6:127587934 RNF146 0.7 9.61 0.47 1.9e-19 Breast cancer; CRC cis rs875971 1.000 rs10257427 chr7:65743208 T/C cg11764359 chr7:65958608 NA -0.61 -9.83 -0.48 3.71e-20 Aortic root size; CRC cis rs6500602 0.527 rs13338333 chr16:4443250 T/C cg08645402 chr16:4508243 NA 0.51 6.56 0.34 2.11e-10 Schizophrenia; CRC cis rs2404602 0.716 rs12441550 chr15:76863682 A/T cg23625390 chr15:77176239 SCAPER 0.47 6.85 0.35 3.61e-11 Blood metabolite levels; CRC cis rs7998202 0.667 rs282578 chr13:113358584 A/G cg02820901 chr13:113351484 ATP11A 0.58 6.39 0.33 5.52e-10 Glycated hemoglobin levels; CRC cis rs501120 0.929 rs528668 chr10:44762584 G/A cg09554077 chr10:44749378 NA 0.78 11.96 0.55 1.33e-27 Coronary artery disease;Coronary heart disease; CRC cis rs1129187 0.755 rs2274514 chr6:42934500 C/T cg21280719 chr6:42927975 GNMT -0.46 -10.46 -0.5 2.64e-22 Alzheimer's disease in APOE e4+ carriers; CRC cis rs7772486 0.875 rs13204280 chr6:146415368 T/C cg13319975 chr6:146136371 FBXO30 -0.4 -6.12 -0.32 2.67e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs7772486 0.681 rs9390343 chr6:146010527 A/T cg05347473 chr6:146136440 FBXO30 -0.39 -5.87 -0.31 1.07e-8 Lobe attachment (rater-scored or self-reported); CRC cis rs798554 1.000 rs798559 chr7:2758341 T/C cg19717773 chr7:2847554 GNA12 -0.45 -6.59 -0.34 1.7e-10 Height; CRC cis rs4819052 0.851 rs13052344 chr21:46676101 C/T cg19498844 chr21:46707878 POFUT2;LOC642852 0.77 11.19 0.52 7.85e-25 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs910187 0.678 rs6122562 chr20:45813847 A/G cg27589058 chr20:45804311 EYA2 -0.41 -8.06 -0.41 1.41e-14 Migraine; CRC cis rs7804356 0.953 rs12534921 chr7:26877210 T/C cg03456212 chr7:26904342 SKAP2 -0.49 -5.62 -0.3 4.1e-8 Type 1 diabetes; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg20863698 chr2:232328446 NCL 0.43 6.02 0.31 4.59e-9 Response to antipsychotic treatment; CRC cis rs10883723 0.810 rs7090034 chr10:104281155 C/G cg11453585 chr10:104263688 ACTR1A;SUFU 0.91 17.47 0.69 8.43e-49 Allergic disease (asthma, hay fever or eczema); CRC trans rs45509595 0.659 rs390764 chr6:27782535 C/T cg16898833 chr6:26189333 HIST1H4D 0.72 6.46 0.34 3.84e-10 Breast cancer; CRC cis rs2762353 0.595 rs9467591 chr6:25742699 C/T cg03517284 chr6:25882590 NA -0.72 -10.33 -0.49 7.8e-22 Blood metabolite levels; CRC cis rs6502050 0.835 rs7208673 chr17:80165908 G/C cg22110888 chr17:80059540 CCDC57 0.39 6.31 0.33 9.23e-10 Life satisfaction; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg13932364 chr1:59762531 FGGY 0.43 6.03 0.32 4.35e-9 Response to antipsychotic treatment; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg07880357 chr17:52977867 TOM1L1 0.43 6.08 0.32 3.24e-9 Response to antipsychotic treatment; CRC cis rs801193 0.761 rs2659888 chr7:66230171 T/G cg00343986 chr7:65444356 GUSB 0.49 7.19 0.37 4.31e-12 Aortic root size; CRC cis rs3820068 0.580 rs7556473 chr1:15996858 C/T cg13390004 chr1:15929781 NA -0.51 -7.28 -0.37 2.49e-12 Systolic blood pressure; CRC cis rs7777754 0.512 rs7785224 chr7:50562361 T/C cg14593290 chr7:50529359 DDC -0.51 -7.7 -0.39 1.64e-13 Response to zileuton treatment in asthma (FEV1 change interaction); CRC cis rs4689592 0.503 rs59640165 chr4:7051661 G/A cg26116260 chr4:7069785 GRPEL1 -0.84 -9.88 -0.48 2.45e-20 Monocyte percentage of white cells; CRC cis rs7937682 0.961 rs4936682 chr11:111629743 T/G cg19812747 chr11:111475976 SIK2 0.48 7.35 0.38 1.56e-12 Primary sclerosing cholangitis; CRC cis rs2734839 0.964 rs2734833 chr11:113292920 G/A cg14159747 chr11:113255604 NA 0.43 7.55 0.38 4.31e-13 Information processing speed; CRC cis rs7224685 0.501 rs1878332 chr17:3904446 G/A cg10724054 chr17:3904396 NA -0.46 -7.57 -0.39 3.84e-13 Type 2 diabetes; CRC cis rs2180341 1.000 rs2038378 chr6:127590400 C/T cg27446573 chr6:127587934 RNF146 0.99 14.71 0.63 5.47e-38 Breast cancer; CRC cis rs4629710 0.592 rs1885641 chr6:131553986 A/G cg12606694 chr6:131520996 AKAP7 0.56 8.3 0.42 2.64e-15 Multiple myeloma (IgH translocation); CRC cis rs12101261 0.580 rs3783950 chr14:81448282 C/G cg06600135 chr14:81408086 NA -0.41 -5.99 -0.31 5.38e-9 Graves' disease; CRC cis rs13191362 0.507 rs2023038 chr6:163119280 C/G cg06582575 chr6:163149167 PACRG;PARK2 -0.45 -6.82 -0.35 4.33e-11 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC trans rs4332037 0.624 rs56256289 chr7:1892529 C/T cg11693508 chr17:37793320 STARD3 0.65 8.49 0.42 7.33e-16 Bipolar disorder; CRC cis rs7208859 0.673 rs9895815 chr17:29138033 A/G cg01831904 chr17:28903510 LRRC37B2 -0.63 -6.5 -0.34 3.04e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs8062405 1.000 rs8062405 chr16:28837906 C/T cg08761264 chr16:28874980 SH2B1 0.42 5.64 0.3 3.71e-8 Cognitive ability (multi-trait analysis);Cognitive ability; CRC cis rs8072100 0.967 rs11079784 chr17:45702280 A/G cg25173405 chr17:45401733 C17orf57 0.47 7.11 0.36 7.29e-12 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs67478160 0.643 rs11626377 chr14:104234357 G/A cg08213375 chr14:104286397 PPP1R13B 0.65 13.66 0.6 6.03e-34 Schizophrenia; CRC trans rs1005277 0.579 rs2505197 chr10:38393310 T/C cg27523141 chr10:43048294 ZNF37B 0.49 7.21 0.37 3.88e-12 Extrinsic epigenetic age acceleration; CRC cis rs7731657 0.537 rs2189510 chr5:130316231 C/T cg08523029 chr5:130500466 HINT1 -0.49 -6.16 -0.32 2.1e-9 Fasting plasma glucose; CRC cis rs6500602 0.701 rs4785971 chr16:4577090 A/G cg06139259 chr16:4526053 HMOX2;NMRAL1 0.51 6.66 0.34 1.18e-10 Schizophrenia; CRC cis rs4363385 0.703 rs4845517 chr1:153003893 T/A cg25856811 chr1:152973957 SPRR3 -0.24 -6.69 -0.35 9.55e-11 Inflammatory skin disease; CRC cis rs16975963 0.793 rs73027418 chr19:38361020 C/T cg15135657 chr19:38346511 NA -0.43 -5.76 -0.3 1.89e-8 Longevity; CRC cis rs4243830 0.850 rs7536908 chr1:6607814 C/T cg22792644 chr1:6614718 TAS1R1;NOL9 -0.77 -9.22 -0.45 3.62e-18 Body mass index; CRC cis rs1448094 0.512 rs11117061 chr12:86250916 G/A cg02569458 chr12:86230093 RASSF9 0.47 7.93 0.4 3.43e-14 Major depressive disorder; CRC cis rs73206853 0.563 rs10400410 chr12:111193499 C/T cg12870014 chr12:110450643 ANKRD13A 0.56 6.03 0.32 4.33e-9 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC cis rs12476592 0.602 rs262509 chr2:63885708 A/G cg10828910 chr2:63850056 LOC388955 0.52 6.44 0.33 4.3e-10 Childhood ear infection; CRC cis rs7208859 0.673 rs78799101 chr17:29215160 A/T cg13385521 chr17:29058706 SUZ12P 0.68 7.96 0.4 2.75e-14 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs7998202 0.614 rs423117 chr13:113346107 C/T cg02820901 chr13:113351484 ATP11A -0.54 -5.9 -0.31 9e-9 Glycated hemoglobin levels; CRC cis rs7605378 1.000 rs7605378 chr2:200676926 A/C cg23649088 chr2:200775458 C2orf69 0.57 7.92 0.4 3.58e-14 Osteoporosis; CRC cis rs2075371 0.966 rs1646646 chr7:133996905 G/T cg11752832 chr7:134001865 SLC35B4 0.49 7.43 0.38 9.23e-13 Mean platelet volume; CRC cis rs270601 0.770 rs4361510 chr5:131599647 C/T cg18301423 chr5:131593218 PDLIM4 0.44 8.17 0.41 6.63e-15 Acylcarnitine levels; CRC cis rs6570726 0.620 rs367693 chr6:145815949 G/A cg23711669 chr6:146136114 FBXO30 0.62 9.29 0.46 2.18e-18 Lobe attachment (rater-scored or self-reported); CRC cis rs28386778 0.863 rs3760252 chr17:61852186 G/C cg25654072 chr17:61904446 PSMC5;FTSJ3 0.73 11.37 0.53 1.75e-25 Prudent dietary pattern; CRC cis rs1552244 0.816 rs13076197 chr3:10019773 T/C cg08888203 chr3:10149979 C3orf24 0.62 8.23 0.41 4.29e-15 Alzheimer's disease; CRC cis rs4478858 0.611 rs10914338 chr1:31733782 T/A cg00250761 chr1:31883323 NA -0.45 -8.8 -0.44 8.05e-17 Alcohol dependence; CRC cis rs8072100 0.713 rs9807106 chr17:45457102 G/T cg08085267 chr17:45401833 C17orf57 -0.59 -8.82 -0.44 6.94e-17 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs4423214 0.879 rs1792277 chr11:71138918 C/T cg05163923 chr11:71159392 DHCR7 -0.65 -7.91 -0.4 3.94e-14 Vitamin D levels; CRC cis rs3018066 0.748 rs7692069 chr4:106959289 C/T cg01869342 chr4:106983673 TBCK 0.45 6.82 0.35 4.32e-11 Cancer; CRC cis rs863345 0.604 rs923664 chr1:158507691 A/T cg12129480 chr1:158549410 OR10X1 -0.3 -6.27 -0.33 1.12e-9 Pneumococcal bacteremia; CRC cis rs2361718 0.603 rs12951255 chr17:78085597 A/G cg08347473 chr17:78092826 GAA -0.32 -5.95 -0.31 7.04e-9 Yeast infection; CRC cis rs9868809 0.542 rs9873726 chr3:48712367 C/T cg07636037 chr3:49044803 WDR6 -0.62 -6.33 -0.33 7.82e-10 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; CRC cis rs11608355 0.545 rs9943724 chr12:109902903 G/A cg05360138 chr12:110035743 NA 0.78 8.76 0.43 1.05e-16 Neuroticism; CRC trans rs2303319 0.504 rs62187658 chr2:162488095 A/C cg12500891 chr11:57225987 NA -0.69 -6.05 -0.32 4.05e-9 Cognitive function; CRC trans rs459571 0.920 rs417142 chr9:136891370 G/T cg15028160 chr19:49622717 PPFIA3;C19orf73 -0.58 -7.26 -0.37 2.76e-12 Platelet distribution width; CRC trans rs3749237 1.000 rs3749237 chr3:49770032 C/T cg21659725 chr3:3221576 CRBN 0.58 8.17 0.41 6.51e-15 Resting heart rate; CRC cis rs932541 1.000 rs6111152 chr20:16456088 A/G cg17003395 chr20:16555519 KIF16B 0.4 5.74 0.3 2.15e-8 Intelligence; CRC cis rs10504229 0.683 rs66893068 chr8:58144238 A/G cg05313129 chr8:58192883 C8orf71 -0.43 -6.1 -0.32 3.05e-9 Developmental language disorder (linguistic errors); CRC cis rs9908102 0.710 rs73981622 chr17:12914834 A/C cg26162695 chr17:12921313 ELAC2 0.43 5.77 0.3 1.86e-8 Schizophrenia; CRC cis rs7727544 0.557 rs715285 chr5:131485383 A/G cg18758796 chr5:131593413 PDLIM4 0.34 5.78 0.3 1.72e-8 Blood metabolite levels; CRC cis rs919433 0.783 rs2565158 chr2:198236103 T/A cg10820045 chr2:198174542 NA 0.45 7.89 0.4 4.58e-14 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC cis rs1218582 0.741 rs7544528 chr1:154844585 C/T cg24250549 chr1:154909240 PMVK 0.57 9.33 0.46 1.6e-18 Prostate cancer; CRC trans rs1814175 0.781 rs2866734 chr11:49886338 A/G cg15704280 chr7:45808275 SEPT13 -1.01 -20.25 -0.74 8.67e-60 Height; CRC cis rs7659604 0.560 rs769238 chr4:122744942 G/A cg20573242 chr4:122745356 CCNA2 0.58 8.67 0.43 1.94e-16 Type 2 diabetes; CRC trans rs1814175 0.669 rs11040473 chr11:49703813 C/T cg11707556 chr5:10655725 ANKRD33B -0.39 -7.33 -0.37 1.76e-12 Height; CRC cis rs4654899 1.000 rs7543126 chr1:21406088 T/G cg02927042 chr1:21476669 EIF4G3 -0.45 -7.11 -0.36 7.26e-12 Superior frontal gyrus grey matter volume; CRC cis rs2019137 0.967 rs895412 chr2:113973964 T/C cg21610815 chr2:113994035 PAX8;LOC654433;LOC440839 -0.46 -6.45 -0.34 4.02e-10 Lymphocyte counts; CRC cis rs7208859 0.623 rs56018041 chr17:29059985 G/A cg01831904 chr17:28903510 LRRC37B2 -0.62 -6.32 -0.33 8.56e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg00472445 chr6:101329307 ASCC3 0.4 6.65 0.34 1.19e-10 Liver disease severity in Alagille syndrome; CRC cis rs13064411 0.696 rs9814395 chr3:113188885 C/T cg18753928 chr3:113234510 CCDC52 -0.66 -10.41 -0.5 3.97e-22 Response to simvastatin treatment (PCSK9 protein level change); CRC cis rs10791097 0.547 rs10791101 chr11:130739133 C/T cg12179176 chr11:130786555 SNX19 0.78 12.99 0.58 2.01e-31 Autism spectrum disorder or schizophrenia;Schizophrenia; CRC cis rs7666738 0.830 rs17550610 chr4:99008273 T/C cg05340658 chr4:99064831 C4orf37 0.61 9.54 0.47 3.44e-19 Colonoscopy-negative controls vs population controls; CRC cis rs7703744 0.634 rs112352373 chr5:118687625 C/G cg17471836 chr5:118691007 TNFAIP8 0.42 5.68 0.3 2.95e-8 Lobe attachment (rater-scored or self-reported); CRC cis rs12188164 0.965 rs72717435 chr5:448202 G/A cg21972741 chr5:435613 AHRR 0.54 7.37 0.38 1.39e-12 Cystic fibrosis severity; CRC trans rs9858542 0.953 rs6766131 chr3:49538932 T/C cg21582582 chr3:182698605 DCUN1D1 -0.51 -6.43 -0.33 4.42e-10 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs7769051 0.522 rs60133731 chr6:133095818 T/C cg22852734 chr6:133119734 C6orf192 0.95 8.62 0.43 2.79e-16 Type 2 diabetes nephropathy; CRC cis rs2415984 0.579 rs11157506 chr14:46976197 T/C cg14871534 chr14:47121158 RPL10L -0.39 -5.81 -0.31 1.46e-8 Number of children ever born; CRC cis rs798554 0.704 rs2527684 chr7:2825922 G/T cg17321639 chr7:2759063 NA -0.41 -6.19 -0.32 1.81e-9 Height; CRC cis rs8180040 0.800 rs11921117 chr3:47294000 T/C cg02527881 chr3:46936655 PTH1R 0.36 6.19 0.32 1.75e-9 Colorectal cancer; CRC trans rs7395662 0.926 rs12288788 chr11:48686863 A/G cg21153622 chr11:89784906 NA -0.44 -7.09 -0.36 8.39e-12 HDL cholesterol; CRC cis rs860295 0.702 rs12043132 chr1:155562367 T/C cg02153340 chr1:155202674 NA -0.49 -6.07 -0.32 3.44e-9 Body mass index; CRC cis rs1862618 0.802 rs33327 chr5:56142693 T/G cg22800045 chr5:56110881 MAP3K1 0.58 6.39 0.33 5.62e-10 Initial pursuit acceleration; CRC cis rs6968419 0.609 rs73716708 chr7:115905743 T/C cg02561103 chr7:115862891 TES -0.41 -6.14 -0.32 2.35e-9 Intraocular pressure; CRC cis rs1580019 0.537 rs7804609 chr7:32558094 A/C cg14728415 chr7:32535168 LSM5;AVL9 0.43 6.13 0.32 2.47e-9 Cognitive ability; CRC cis rs9311474 0.508 rs4687629 chr3:52615227 G/C cg10802521 chr3:52805072 NEK4 -0.58 -9.23 -0.45 3.45e-18 Electroencephalogram traits; CRC cis rs17095355 0.605 rs41291880 chr10:111635785 A/G cg00817464 chr10:111662876 XPNPEP1 -0.45 -5.78 -0.3 1.7e-8 Biliary atresia; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg00589895 chr3:172429056 NCEH1 0.47 6.55 0.34 2.18e-10 Response to antipsychotic treatment; CRC cis rs17443541 0.507 rs12613262 chr2:200465327 T/C cg03741458 chr2:200468445 NA -0.36 -5.77 -0.3 1.82e-8 Intelligence (multi-trait analysis); CRC cis rs752010 0.967 rs752011 chr1:42092929 C/T cg06885757 chr1:42089581 HIVEP3 0.48 8.43 0.42 1.08e-15 Lupus nephritis in systemic lupus erythematosus; CRC cis rs7590720 1.000 rs7590720 chr2:216898658 A/G cg12620499 chr2:216877984 MREG -0.83 -13.79 -0.61 1.85e-34 Alcohol dependence; CRC cis rs9816226 0.618 rs1516728 chr3:185829891 A/T cg00760338 chr3:185826511 ETV5 0.8 11.29 0.53 3.32e-25 Obesity;Body mass index; CRC cis rs2380220 0.808 rs2716069 chr6:95912976 C/G cg04719120 chr6:96025338 MANEA -0.53 -5.88 -0.31 9.93e-9 Behavioural disinhibition (generation interaction); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg02905663 chr8:119123707 EXT1 0.4 6.27 0.33 1.17e-9 Liver disease severity in Alagille syndrome; CRC cis rs12541335 0.639 rs35068739 chr8:22201719 T/C cg18135555 chr8:22132992 PIWIL2 0.42 8.17 0.41 6.87e-15 Hypertriglyceridemia; CRC cis rs9311474 0.508 rs12629701 chr3:52619836 T/C cg11645453 chr3:52864694 ITIH4 0.32 5.71 0.3 2.46e-8 Electroencephalogram traits; CRC cis rs847577 0.630 rs11764933 chr7:97825188 G/A cg21770322 chr7:97807741 LMTK2 0.86 19.38 0.73 2.28e-56 Breast cancer; CRC cis rs3751196 0.708 rs79553328 chr12:104149708 A/G cg02344784 chr12:104178138 NT5DC3 0.68 6.33 0.33 8.16e-10 Sense of smell; CRC trans rs951252 0.504 rs11734405 chr4:146081096 C/T cg24474130 chr6:99282348 POU3F2 0.35 6.01 0.31 5e-9 Hip circumference; CRC cis rs10540 0.818 rs12806089 chr11:501468 G/A cg19913688 chr11:428466 ANO9 -0.7 -7.19 -0.37 4.26e-12 Body mass index; CRC cis rs12477438 0.765 rs13390672 chr2:99589829 C/T cg14399236 chr2:99771627 LIPT1;TSGA10 -0.6 -8.21 -0.41 5.18e-15 Chronic sinus infection; CRC cis rs4862750 0.872 rs6821507 chr4:187876829 G/T cg11301795 chr4:187892539 NA 0.84 18.93 0.72 1.44e-54 Lobe attachment (rater-scored or self-reported); CRC cis rs9292777 0.720 rs56694910 chr5:40401152 T/G cg09067459 chr5:40385259 NA -0.55 -8.97 -0.44 2.31e-17 Crohn's disease;Multiple sclerosis; CRC cis rs61524473 1 rs61524473 chr15:45646283 T/C cg10760299 chr15:45669010 GATM 0.49 7.79 0.39 8.71e-14 Metabolite levels (small molecules and protein measures); CRC cis rs1005277 0.579 rs1780115 chr10:38524773 C/T cg00409905 chr10:38381863 ZNF37A -0.62 -10.29 -0.49 1.04e-21 Extrinsic epigenetic age acceleration; CRC cis rs7120118 0.517 rs56825896 chr11:47326184 A/G cg25783544 chr11:47291846 MADD 0.62 5.77 0.3 1.81e-8 HDL cholesterol; CRC cis rs6743376 0.556 rs2515392 chr2:113817181 C/T cg09040174 chr2:113837401 NA 0.44 6.42 0.33 4.87e-10 Inflammatory biomarkers; CRC cis rs11711311 0.955 rs1048892 chr3:113464859 A/G cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.51 -6.94 -0.36 2.14e-11 IgG glycosylation; CRC cis rs300703 0.515 rs424292 chr2:191931 C/T cg21211680 chr2:198530 NA -0.71 -8.82 -0.44 7.06e-17 Blood protein levels; CRC cis rs7044106 0.762 rs1547267 chr9:123408736 T/C cg14255062 chr9:123606675 PSMD5;LOC253039 0.44 6.28 0.33 1.07e-9 Hip circumference adjusted for BMI; CRC cis rs12477438 0.501 rs1133977 chr2:99741984 G/T cg14399236 chr2:99771627 LIPT1;TSGA10 -0.74 -12.49 -0.57 1.42e-29 Chronic sinus infection; CRC cis rs739401 0.619 rs10766482 chr11:2961600 C/T cg05729581 chr11:3078854 CARS -0.51 -7.27 -0.37 2.57e-12 Longevity; CRC cis rs9814567 1.000 rs9851441 chr3:134315091 C/A cg06541857 chr3:134203789 ANAPC13;CEP63 -0.38 -5.62 -0.3 4.06e-8 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs12936587 0.601 rs8068296 chr17:17554563 A/C cg09796270 chr17:17721594 SREBF1 -0.45 -7.58 -0.39 3.45e-13 Hip circumference;Coronary artery disease or large artery stroke;Coronary heart disease;Coronary artery disease; CRC cis rs56283067 0.887 rs9472365 chr6:44770214 C/G cg18551225 chr6:44695536 NA 0.41 5.6 0.3 4.52e-8 Total body bone mineral density; CRC trans rs10411161 0.579 rs59305384 chr19:52387064 A/G cg22319618 chr22:45562946 NUP50 -0.58 -6.82 -0.35 4.36e-11 Breast cancer; CRC cis rs1552244 0.554 rs3732963 chr3:10048885 G/T cg16606324 chr3:10149918 C3orf24 0.48 7.03 0.36 1.19e-11 Alzheimer's disease; CRC trans rs1814175 0.615 rs11040654 chr11:49939485 T/G cg03929089 chr4:120376271 NA -0.91 -16.07 -0.66 2.65e-43 Height; CRC cis rs6089584 0.888 rs2386555 chr20:60612373 C/T cg18761221 chr20:60518478 NA 0.45 7.3 0.37 2.24e-12 Body mass index; CRC cis rs7408868 0.520 rs10417567 chr19:15308068 C/T cg14696996 chr19:15285081 NOTCH3 -0.84 -8.3 -0.42 2.65e-15 Pulse pressure; CRC trans rs3001167 0.867 rs10921615 chr1:194557475 A/T cg22004422 chr13:113740730 MCF2L -0.57 -6.32 -0.33 8.35e-10 Obesity-related traits; CRC cis rs57221529 0.766 rs72703070 chr5:590458 T/C cg14541582 chr5:601475 NA -0.36 -7.11 -0.36 7.3e-12 Lung disease severity in cystic fibrosis; CRC cis rs597539 0.617 rs672853 chr11:68636362 G/A cg21963583 chr11:68658836 MRPL21 0.64 11.28 0.53 3.58e-25 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs67478160 0.619 rs12885018 chr14:104273812 A/G cg08213375 chr14:104286397 PPP1R13B 0.62 12.96 0.58 2.67e-31 Schizophrenia; CRC cis rs16852403 0.581 rs10913525 chr1:178223433 G/A cg00404053 chr1:178313656 RASAL2 0.52 6.75 0.35 6.58e-11 Childhood ear infection; CRC cis rs10193935 0.748 rs12467253 chr2:42697588 A/C cg27598129 chr2:42591480 NA 0.68 7.65 0.39 2.23e-13 Colonoscopy-negative controls vs population controls; CRC cis rs7680126 0.596 rs12510549 chr4:10276467 A/G cg11266682 chr4:10021025 SLC2A9 -0.38 -5.9 -0.31 9.04e-9 Urate levels in lean individuals;Urate levels in overweight individuals;Urate levels in obese individuals; CRC cis rs7809950 1.000 rs10258385 chr7:107243350 T/C cg23024343 chr7:107201750 COG5 0.65 9.39 0.46 1.01e-18 Coronary artery disease; CRC cis rs951366 0.585 rs72750964 chr1:205675240 C/T cg07167872 chr1:205819463 PM20D1 0.79 11.7 0.54 1.14e-26 Menarche (age at onset); CRC cis rs2075671 0.903 rs11983334 chr7:100302434 C/T cg00334542 chr7:100209784 MOSPD3 -0.53 -6.82 -0.35 4.47e-11 Other erythrocyte phenotypes; CRC cis rs10256972 0.684 rs4724039 chr7:1111633 A/G cg23978390 chr7:1156363 C7orf50 0.42 5.87 0.31 1.06e-8 Longevity;Endometriosis; CRC cis rs6942756 0.806 rs2566886 chr7:128917866 G/A cg02491457 chr7:128862824 NA 0.66 9.1 0.45 9.14e-18 White matter hyperintensity burden; CRC cis rs9837602 0.529 rs793495 chr3:99507934 A/G cg07805332 chr3:99536008 MIR548G;C3orf26 -0.5 -7.36 -0.38 1.48e-12 Breast cancer; CRC cis rs10206020 0.885 rs11899557 chr2:1576123 G/T cg26248373 chr2:1572462 NA -0.83 -12.33 -0.56 5.69e-29 IgG glycosylation; CRC cis rs736408 0.716 rs2239550 chr3:52822509 G/C cg07507251 chr3:52567010 NT5DC2 0.4 5.63 0.3 3.81e-8 Bipolar disorder; CRC cis rs1008375 1.000 rs28693609 chr4:17645233 C/T cg16339924 chr4:17578868 LAP3 0.57 7.72 0.39 1.37e-13 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs9517320 1.000 rs7996629 chr13:99128037 C/T cg07423050 chr13:99094983 FARP1 0.41 6.57 0.34 1.93e-10 Longevity; CRC cis rs2658782 0.826 rs1975820 chr11:93081815 G/A cg15737290 chr11:93063684 CCDC67 0.54 7.77 0.39 1.01e-13 Pulmonary function decline; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg04119843 chr1:1284268 DVL1 0.51 6.58 0.34 1.85e-10 Thyroid stimulating hormone; CRC cis rs2688482 0.512 rs3103953 chr3:195520597 G/A cg05834845 chr3:195489306 MUC4 -0.67 -7.29 -0.37 2.38e-12 Lung disease severity in cystic fibrosis; CRC cis rs79387448 0.745 rs72993720 chr2:103121269 A/T cg00507830 chr2:103233733 NA 0.5 5.63 0.3 3.86e-8 Gut microbiota (bacterial taxa); CRC cis rs10751667 0.643 rs10751671 chr11:944479 T/G cg06064525 chr11:970664 AP2A2 -0.31 -6.16 -0.32 2.18e-9 Alzheimer's disease (late onset); CRC cis rs1355223 0.872 rs7112608 chr11:34699269 G/T cg11058730 chr11:34937778 PDHX;APIP -0.41 -5.62 -0.3 4.05e-8 Systemic lupus erythematosus and Systemic sclerosis; CRC cis rs9807841 0.568 rs3859514 chr19:10748820 T/C cg17710535 chr19:10819994 QTRT1 0.42 5.8 0.3 1.58e-8 Inflammatory skin disease; CRC cis rs4481887 0.927 rs10127803 chr1:248476196 A/T cg13385794 chr1:248469461 NA 0.38 6.75 0.35 6.84e-11 Common traits (Other); CRC cis rs7726839 0.540 rs57306627 chr5:597643 T/C cg16447950 chr5:562315 NA -0.71 -9.55 -0.47 3.07e-19 Obesity-related traits; CRC trans rs8073060 0.586 rs2523114 chr17:34023762 G/A cg19694781 chr19:47549865 TMEM160 -1.07 -14.44 -0.62 6.2e-37 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; CRC cis rs9323205 0.677 rs12587080 chr14:51723079 A/C cg23942311 chr14:51606299 NA -0.52 -6.19 -0.32 1.78e-9 Cancer; CRC cis rs4555082 0.834 rs2975217 chr14:105710238 A/C cg18132624 chr14:105716052 BTBD6;BRF1 -0.47 -7.66 -0.39 2.08e-13 Mean platelet volume;Platelet distribution width; CRC cis rs10078 0.571 rs2721028 chr5:443849 A/G cg07599136 chr5:415885 AHRR 0.76 7.43 0.38 9.2e-13 Fat distribution (HIV); CRC cis rs79349575 0.756 rs937301 chr17:47046276 A/G cg00947319 chr17:47005597 UBE2Z 0.34 5.69 0.3 2.87e-8 Type 2 diabetes; CRC cis rs4654899 0.895 rs10916865 chr1:21136610 C/T cg02927042 chr1:21476669 EIF4G3 0.42 6.71 0.35 8.47e-11 Superior frontal gyrus grey matter volume; CRC cis rs9359856 0.564 rs34766278 chr6:90397132 G/C cg13799429 chr6:90582589 CASP8AP2 -0.73 -8.07 -0.41 1.36e-14 Bipolar disorder; CRC cis rs9549367 0.713 rs3024746 chr13:113821777 G/A cg24300038 chr13:113819356 PROZ -0.47 -6.03 -0.32 4.5e-9 Platelet distribution width; CRC cis rs4728302 0.869 rs2059298 chr7:133603245 C/G cg03336402 chr7:133662267 EXOC4 -0.45 -6.52 -0.34 2.61e-10 Intelligence;Intelligence (multi-trait analysis); CRC cis rs853679 0.517 rs34716816 chr6:28046169 C/A cg02631126 chr6:28058918 ZSCAN12L1 0.29 6.1 0.32 2.95e-9 Depression; CRC cis rs9649213 0.593 rs6949214 chr7:97960233 G/A cg08684580 chr7:98029266 BAIAP2L1 -0.32 -5.65 -0.3 3.44e-8 Prostate cancer (SNP x SNP interaction); CRC cis rs9302065 0.681 rs59108692 chr13:95962424 C/A cg26751094 chr13:95954534 ABCC4 -0.34 -6.03 -0.32 4.34e-9 Blood metabolite levels; CRC cis rs7666738 0.791 rs10033994 chr4:98969582 C/T cg17366294 chr4:99064904 C4orf37 0.44 7.44 0.38 8.98e-13 Colonoscopy-negative controls vs population controls; CRC cis rs2180341 0.597 rs11154397 chr6:127646649 G/C cg24812749 chr6:127587940 RNF146 0.65 9.54 0.47 3.27e-19 Breast cancer; CRC cis rs1348850 0.597 rs13014417 chr2:178417835 T/G cg27490568 chr2:178487706 NA 0.53 6.63 0.34 1.4e-10 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC trans rs6686842 1.000 rs6600365 chr1:41556253 C/T cg19787969 chr8:9763211 NA 0.28 6.03 0.32 4.28e-9 Height; CRC trans rs561341 1.000 rs2344312 chr17:30243583 G/T cg27661571 chr11:113659931 NA -0.56 -7.24 -0.37 3.15e-12 Hip circumference adjusted for BMI; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg13580096 chr8:66546317 ARMC1 0.35 6.0 0.31 5.1e-9 Liver disease severity in Alagille syndrome; CRC cis rs35123781 0.696 rs904612 chr5:139070952 G/A cg10513866 chr5:139070639 NA 0.55 8.61 0.43 3.03e-16 Schizophrenia; CRC cis rs1215050 0.716 rs11940331 chr4:99054041 G/C cg05340658 chr4:99064831 C4orf37 0.49 7.48 0.38 6.88e-13 Waist-to-hip ratio adjusted for body mass index; CRC cis rs734999 0.524 rs4648448 chr1:2695687 C/T cg18854424 chr1:2615690 NA 0.42 7.88 0.4 4.77e-14 Ulcerative colitis; CRC cis rs9611565 0.659 rs9611609 chr22:41945357 C/A cg03806693 chr22:41940476 POLR3H -1.14 -15.46 -0.65 6.69e-41 Vitiligo; CRC cis rs6088580 0.634 rs2424992 chr20:33012060 C/T cg08999081 chr20:33150536 PIGU 0.61 11.47 0.53 7.73e-26 Glomerular filtration rate (creatinine); CRC cis rs7677751 0.806 rs1800810 chr4:55094031 C/G cg13615338 chr4:55094005 PDGFRA 0.4 5.95 0.31 6.86e-9 Corneal astigmatism; CRC cis rs7208859 0.673 rs216420 chr17:28938508 C/T cg14008862 chr17:28927542 LRRC37B2 0.53 6.18 0.32 1.9e-9 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs4713118 0.662 rs9468271 chr6:28024570 A/G cg06470822 chr6:28175283 NA 0.95 13.59 0.6 1.07e-33 Parkinson's disease; CRC cis rs7249142 0.549 rs12609573 chr19:19297567 C/T cg12558012 chr19:19281197 LOC729991-MEF2B;MEF2B -0.58 -9.25 -0.45 3.02e-18 IgG glycosylation; CRC cis rs1008375 1.000 rs13106338 chr4:17676871 G/T cg16339924 chr4:17578868 LAP3 -0.54 -7.06 -0.36 9.78e-12 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs6500602 0.702 rs3761680 chr16:4524060 C/A cg14951292 chr16:4525986 HMOX2;NMRAL1 0.56 8.48 0.42 7.87e-16 Schizophrenia; CRC cis rs2228479 0.681 rs2270461 chr16:89972345 C/T cg04013166 chr16:89971882 TCF25 -0.66 -8.56 -0.43 4.26e-16 Skin colour saturation; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg14644898 chr2:9615234 IAH1 0.48 6.24 0.33 1.37e-9 Thyroid stimulating hormone; CRC cis rs9372498 0.536 rs13437605 chr6:118899014 C/T cg18833306 chr6:118973337 C6orf204 0.44 5.77 0.3 1.8e-8 Diastolic blood pressure; CRC cis rs12930096 1.000 rs12929430 chr16:11679467 C/T cg07439791 chr16:11680400 LITAF 0.51 5.62 0.3 4e-8 QT interval; CRC cis rs875971 1.000 rs4717300 chr7:65947380 T/C cg00343986 chr7:65444356 GUSB 0.44 6.38 0.33 6.09e-10 Aortic root size; CRC cis rs6743226 0.934 rs6704615 chr2:242228733 A/G cg10021735 chr2:242295487 FARP2 -0.46 -6.83 -0.35 4.18e-11 Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI in non-smokers; CRC cis rs763014 0.932 rs34498660 chr16:666149 A/G cg00802000 chr16:706648 WDR90 -0.46 -6.74 -0.35 7.19e-11 Height; CRC cis rs72945132 0.882 rs55915603 chr11:70210067 G/T cg00319359 chr11:70116639 PPFIA1 0.65 6.86 0.35 3.38e-11 Coronary artery disease; CRC cis rs1008375 1.000 rs917665 chr4:17668504 A/C cg04450456 chr4:17643702 FAM184B -0.36 -5.6 -0.3 4.5e-8 Parasitemia in Tripanosoma cruzi seropositivity; CRC trans rs7267979 1.000 rs4815404 chr20:25301845 T/G cg17903999 chr18:56338584 MALT1 0.42 6.86 0.35 3.47e-11 Liver enzyme levels (alkaline phosphatase); CRC cis rs743757 1.000 rs6446206 chr3:50455470 G/A cg08207895 chr3:50388901 TUSC4;CYB561D2 0.43 6.07 0.32 3.47e-9 Diastolic blood pressure; CRC cis rs769267 0.859 rs2916076 chr19:19545990 T/C cg03709012 chr19:19516395 GATAD2A 0.74 11.67 0.54 1.45e-26 Tonsillectomy; CRC cis rs10924970 0.624 rs12755851 chr1:235477806 G/C cg09010748 chr1:235293032 TOMM20 -0.4 -5.65 -0.3 3.57e-8 Asthma; CRC cis rs1008375 0.966 rs11947836 chr4:17697187 A/G cg16339924 chr4:17578868 LAP3 -0.49 -6.38 -0.33 5.85e-10 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs172166 0.694 rs536704 chr6:28092603 T/G cg03623178 chr6:28175578 NA 0.77 11.48 0.53 7.23e-26 Cardiac Troponin-T levels; CRC cis rs990171 0.607 rs871659 chr2:102771855 C/T cg22835712 chr2:102737379 NA 0.46 5.93 0.31 7.79e-9 Lymphocyte counts; CRC cis rs10504229 0.683 rs11774697 chr8:58133119 G/A cg11062466 chr8:58055876 NA 0.54 6.81 0.35 4.57e-11 Developmental language disorder (linguistic errors); CRC cis rs10504229 0.817 rs78138632 chr8:58191341 G/T cg02290350 chr8:58132656 NA -0.52 -5.68 -0.3 2.89e-8 Developmental language disorder (linguistic errors); CRC cis rs3087591 0.887 rs1013946 chr17:29530350 A/C cg24425628 chr17:29625626 OMG;NF1 0.82 15.58 0.65 2.32e-41 Hip circumference; CRC cis rs1451375 0.572 rs68011952 chr7:50638128 C/T cg14593290 chr7:50529359 DDC 0.56 7.24 0.37 3.13e-12 Malaria; CRC cis rs1572438 0.811 rs6916781 chr6:880493 G/A cg13447295 chr6:887704 NA 0.55 8.4 0.42 1.4e-15 Aging; CRC cis rs3731896 0.752 rs11889536 chr2:220163543 A/G cg00436969 chr2:220197716 RESP18 -0.45 -5.73 -0.3 2.28e-8 Educational attainment; CRC trans rs875971 0.660 rs2191268 chr7:66110224 C/T cg06057045 chr2:233562093 GIGYF2 -0.4 -6.0 -0.31 5.28e-9 Aortic root size; CRC cis rs4423214 0.879 rs1792284 chr11:71134966 A/G cg05163923 chr11:71159392 DHCR7 0.62 7.39 0.38 1.2e-12 Vitamin D levels; CRC cis rs17021463 0.676 rs11097421 chr4:95302915 T/C cg11021082 chr4:95130006 SMARCAD1 0.44 6.32 0.33 8.75e-10 Testicular germ cell tumor; CRC cis rs7312933 0.865 rs1920687 chr12:42398275 T/C cg17420585 chr12:42539391 GXYLT1 -0.4 -5.78 -0.3 1.74e-8 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CRC cis rs7937682 0.889 rs10749984 chr11:111492861 T/C cg19812747 chr11:111475976 SIK2 -0.59 -10.14 -0.49 3.31e-21 Primary sclerosing cholangitis; CRC cis rs9515201 0.740 rs9555695 chr13:111033125 C/T cg06243866 chr13:111019493 COL4A2 -0.39 -5.85 -0.31 1.19e-8 White matter hyperintensity burden; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg08442028 chr16:87425757 FBXO31;MAP1LC3B 0.44 6.15 0.32 2.3e-9 Anxiety disorder; CRC cis rs10504229 1.000 rs57261109 chr8:58172152 C/T cg22535103 chr8:58192502 C8orf71 -0.82 -12.27 -0.56 9.63e-29 Developmental language disorder (linguistic errors); CRC trans rs7819412 0.811 rs2409691 chr8:10943276 C/T cg06636001 chr8:8085503 FLJ10661 -0.48 -6.98 -0.36 1.67e-11 Triglycerides; CRC cis rs11212617 0.967 rs371406 chr11:108221482 A/G cg01991180 chr11:108092276 ATM;NPAT 0.42 5.97 0.31 6.15e-9 Response to metformin in type 2 diabetes (glycemic); CRC cis rs875971 0.597 rs11763224 chr7:65983615 G/T cg03233332 chr7:66118400 NA -0.43 -5.95 -0.31 6.81e-9 Aortic root size; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg04909336 chr12:46121883 LOC400027 0.45 6.39 0.33 5.73e-10 Intelligence (multi-trait analysis); CRC cis rs7666738 0.830 rs9998582 chr4:98938949 T/C cg17366294 chr4:99064904 C4orf37 0.43 7.32 0.37 1.95e-12 Colonoscopy-negative controls vs population controls; CRC cis rs9311474 0.629 rs13081028 chr3:52555316 G/A cg17372223 chr3:52568218 NT5DC2 0.41 6.24 0.33 1.33e-9 Electroencephalogram traits; CRC cis rs11190604 1.000 rs3750626 chr10:102266316 C/T cg16342193 chr10:102329863 NA -0.36 -6.08 -0.32 3.25e-9 Palmitoleic acid (16:1n-7) levels; CRC cis rs9611565 0.512 rs9611667 chr22:42187015 C/T cg17554472 chr22:41940697 POLR3H -0.56 -5.7 -0.3 2.67e-8 Vitiligo; CRC trans rs3733585 0.648 rs28513781 chr4:9959334 G/C cg26043149 chr18:55253948 FECH -0.5 -7.62 -0.39 2.81e-13 Cleft plate (environmental tobacco smoke interaction); CRC cis rs1018836 0.923 rs7840846 chr8:91565501 T/A cg16814680 chr8:91681699 NA -0.74 -11.7 -0.54 1.17e-26 Ejection fraction in Tripanosoma cruzi seropositivity; CRC cis rs9916302 0.861 rs2338801 chr17:37490780 G/T cg07936489 chr17:37558343 FBXL20 0.76 11.26 0.53 4.17e-25 Glomerular filtration rate (creatinine); CRC cis rs601339 0.938 rs1696344 chr12:123183059 C/T cg25190513 chr12:123201362 GPR109B -0.51 -6.35 -0.33 7.29e-10 Adiponectin levels; CRC cis rs736408 0.540 rs4687637 chr3:52634092 C/T cg18404041 chr3:52824283 ITIH1 -0.41 -8.67 -0.43 1.96e-16 Bipolar disorder; CRC cis rs853679 0.517 rs9393888 chr6:28059217 G/C cg18032046 chr6:28092343 ZSCAN16 -0.5 -5.84 -0.31 1.26e-8 Depression; CRC cis rs7937682 0.562 rs7938620 chr11:111366844 G/A cg09085632 chr11:111637200 PPP2R1B 0.57 8.18 0.41 6.29e-15 Primary sclerosing cholangitis; CRC cis rs910187 0.605 rs6018317 chr20:45803236 A/G cg27589058 chr20:45804311 EYA2 -0.41 -7.91 -0.4 3.85e-14 Migraine; CRC cis rs9912789 0.687 rs9892874 chr17:79188303 G/C cg25342872 chr17:79175132 AZI1 -0.44 -7.83 -0.4 6.57e-14 Frontotemporal dementia; CRC cis rs1552244 1.000 rs35198334 chr3:10104553 G/C cg00166722 chr3:10149974 C3orf24 0.71 9.42 0.46 8.32e-19 Alzheimer's disease; CRC cis rs1003719 0.680 rs1034357 chr21:38571482 G/C cg10648535 chr21:38446584 PIGP;TTC3 -0.45 -6.23 -0.32 1.41e-9 Eye color traits; CRC cis rs2257205 0.667 rs77326197 chr17:56905618 T/C cg25885038 chr17:56607967 SEPT4 -0.53 -5.85 -0.31 1.2e-8 Pancreatic cancer; CRC cis rs4664293 0.836 rs13401087 chr2:160617468 G/C cg08347373 chr2:160653686 CD302 -0.47 -7.43 -0.38 9.32e-13 Monocyte percentage of white cells; CRC cis rs60154123 0.505 rs76101197 chr1:210044089 T/C cg22029157 chr1:209979665 IRF6 0.61 6.73 0.35 7.5e-11 Coronary artery disease; CRC cis rs7811142 1.000 rs6975729 chr7:100028187 C/T cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.19 17.69 0.7 1.13e-49 Platelet count; CRC cis rs8060686 0.920 rs58588228 chr16:67802010 C/T cg19582491 chr16:67682965 RLTPR -0.57 -6.53 -0.34 2.56e-10 HDL cholesterol;Metabolic syndrome; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg12950166 chr12:122517149 MLXIP 0.4 6.28 0.33 1.06e-9 Liver disease severity in Alagille syndrome; CRC cis rs875971 0.964 rs778735 chr7:65814809 C/A cg11764359 chr7:65958608 NA 0.63 10.08 0.49 5.47e-21 Aortic root size; CRC cis rs7607369 0.566 rs55658481 chr2:219284215 G/A cg02176678 chr2:219576539 TTLL4 -0.56 -8.32 -0.42 2.38e-15 Red blood cell count;Amyotrophic lateral sclerosis; CRC cis rs2836974 0.899 rs8127087 chr21:40544502 C/T cg11890956 chr21:40555474 PSMG1 1.08 18.6 0.72 2.69e-53 Cognitive function; CRC cis rs1046896 0.514 rs9894705 chr17:80823758 A/C cg19500275 chr17:80737654 TBCD -0.51 -7.07 -0.36 9.41e-12 Glycated hemoglobin levels; CRC trans rs3780486 0.846 rs12554995 chr9:33132044 A/G cg04842962 chr6:43655489 MRPS18A 1.16 25.92 0.82 1.73e-81 IgG glycosylation; CRC cis rs8141529 0.719 rs6005916 chr22:29233342 T/C cg15103426 chr22:29168792 CCDC117 0.59 8.61 0.43 3.08e-16 Lymphocyte counts; CRC cis rs947211 0.846 rs708726 chr1:205762139 G/T cg26354017 chr1:205819088 PM20D1 -0.45 -6.65 -0.34 1.25e-10 Parkinson's disease; CRC trans rs2727020 0.521 rs7114564 chr11:49571231 C/T cg11707556 chr5:10655725 ANKRD33B 0.46 7.71 0.39 1.48e-13 Coronary artery disease; CRC cis rs9916302 0.904 rs2338798 chr17:37547269 T/C cg03013999 chr17:37608204 MED1 -0.47 -7.31 -0.37 2.1e-12 Glomerular filtration rate (creatinine); CRC cis rs9527 0.615 rs10883781 chr10:104581130 A/G cg23093090 chr10:104574429 C10orf26 -0.42 -5.79 -0.3 1.65e-8 Arsenic metabolism; CRC cis rs3087591 0.664 rs2854308 chr17:29666539 A/G cg24425628 chr17:29625626 OMG;NF1 0.68 12.48 0.57 1.58e-29 Hip circumference; CRC cis rs4689388 0.853 rs13103357 chr4:6294544 A/G cg00701064 chr4:6280414 WFS1 0.75 13.24 0.59 2.21e-32 Type 2 diabetes and other traits;Type 2 diabetes; CRC cis rs7617773 0.780 rs71323395 chr3:48374077 G/A cg11946769 chr3:48343235 NME6 0.74 9.91 0.48 2.03e-20 Coronary artery disease; CRC cis rs6582630 0.622 rs11182004 chr12:38441254 G/A cg26384229 chr12:38710491 ALG10B -0.51 -7.34 -0.38 1.63e-12 Drug-induced liver injury (flucloxacillin); CRC cis rs1707322 0.691 rs61784799 chr1:46177748 A/G cg03146154 chr1:46216737 IPP -0.68 -9.79 -0.47 5.12e-20 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs2075371 0.933 rs2544201 chr7:133963561 C/G cg02659138 chr7:134003124 SLC35B4 0.36 6.14 0.32 2.41e-9 Mean platelet volume; CRC cis rs17270561 0.609 rs7746502 chr6:25718762 T/A cg17691542 chr6:26056736 HIST1H1C -0.6 -8.29 -0.42 2.86e-15 Iron status biomarkers; CRC cis rs7666738 0.830 rs2903154 chr4:99048151 A/G cg05340658 chr4:99064831 C4orf37 0.58 8.91 0.44 3.67e-17 Colonoscopy-negative controls vs population controls; CRC trans rs1973993 0.662 rs2057427 chr1:96888897 C/G cg10631902 chr5:14652156 NA -0.43 -7.05 -0.36 1.06e-11 Weight; CRC cis rs7726839 0.540 rs11739847 chr5:609661 G/A cg17948913 chr5:572064 NA 0.51 5.91 0.31 8.58e-9 Obesity-related traits; CRC cis rs1008375 1.000 rs28693609 chr4:17645233 C/T cg04450456 chr4:17643702 FAM184B 0.4 6.51 0.34 2.8e-10 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs6860806 0.661 rs28472559 chr5:131581611 G/A cg18758796 chr5:131593413 PDLIM4 0.43 7.91 0.4 4.08e-14 Breast cancer; CRC cis rs4660531 0.890 rs61229336 chr1:41834935 C/T cg00290994 chr1:41848739 NA 0.47 6.55 0.34 2.16e-10 Bipolar disorder; CRC trans rs1814175 0.935 rs28586931 chr11:49693872 G/A cg03929089 chr4:120376271 NA -0.94 -17.26 -0.69 5.36e-48 Height; CRC cis rs1552244 0.882 rs13077641 chr3:10022935 G/A cg13047869 chr3:10149882 C3orf24 0.51 6.91 0.36 2.54e-11 Alzheimer's disease; CRC cis rs1055129 0.655 rs8067076 chr17:73837142 G/T cg08125733 chr17:73851984 WBP2 -0.43 -5.94 -0.31 7.16e-9 White matter hyperintensity burden; CRC cis rs55665837 1.000 rs2305305 chr11:14540942 C/T cg19336497 chr11:14380999 RRAS2 -0.4 -6.7 -0.35 9.25e-11 Vitamin D levels; CRC cis rs7215564 0.822 rs10871488 chr17:78739079 T/C cg09596252 chr17:78655493 RPTOR -0.56 -5.89 -0.31 9.59e-9 Myopia (pathological); CRC cis rs5750830 0.649 rs5750813 chr22:39795228 G/C cg25956985 chr22:39795188 MAP3K7IP1 -0.47 -6.7 -0.35 9.04e-11 Intelligence (multi-trait analysis); CRC cis rs754466 0.580 rs2579177 chr10:79529245 C/T cg26805224 chr10:79626177 DLG5 -0.46 -6.85 -0.35 3.54e-11 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs524281 0.861 rs7935336 chr11:65865325 C/T cg16950941 chr11:66035639 RAB1B -0.6 -7.39 -0.38 1.23e-12 Electroencephalogram traits; CRC trans rs2303319 0.504 rs56405014 chr2:162497603 C/T cg03757145 chr4:76555832 CDKL2 -0.66 -5.97 -0.31 5.99e-9 Cognitive function; CRC cis rs11122272 0.735 rs2749709 chr1:231530476 G/T cg06096015 chr1:231504339 EGLN1 0.39 5.83 0.31 1.29e-8 Hemoglobin concentration; CRC trans rs2228479 0.850 rs17233567 chr16:89813821 G/A cg24644049 chr4:85504048 CDS1 0.9 7.46 0.38 7.69e-13 Skin colour saturation; CRC cis rs875971 1.000 rs6963646 chr7:65685767 T/C cg18912574 chr7:65842487 NCRNA00174 -0.37 -6.48 -0.34 3.39e-10 Aortic root size; CRC cis rs780096 0.526 rs780117 chr2:27698343 C/G cg24768116 chr2:27665128 KRTCAP3 -0.36 -8.12 -0.41 9.76e-15 Total body bone mineral density; CRC cis rs977987 0.806 rs11149832 chr16:75462713 C/T cg03315344 chr16:75512273 CHST6 0.55 9.25 0.45 3.01e-18 Dupuytren's disease; CRC cis rs425277 0.606 rs262653 chr1:2090095 T/G cg12639453 chr1:2035780 PRKCZ 0.31 5.71 0.3 2.55e-8 Height; CRC cis rs2153535 0.580 rs4365970 chr6:8453813 C/T cg07606381 chr6:8435919 SLC35B3 -0.68 -10.6 -0.5 8.97e-23 Motion sickness; CRC cis rs34172651 0.517 rs36113933 chr16:24838862 A/G cg06028605 chr16:24865363 SLC5A11 0.59 9.75 0.47 6.74e-20 Intelligence (multi-trait analysis); CRC cis rs7591163 1.000 rs2396499 chr2:228724368 C/T cg23807890 chr2:228736357 WDR69 0.46 6.26 0.33 1.18e-9 Blood pressure; CRC cis rs17065868 0.764 rs9533868 chr13:45039441 G/A cg10246903 chr13:45222710 NA 0.54 5.69 0.3 2.79e-8 Antineutrophil cytoplasmic antibody-associated vasculitis; CRC cis rs72615157 0.634 rs79986079 chr7:99802044 C/T cg13153964 chr7:100026424 MEPCE;ZCWPW1 0.78 9.46 0.46 5.95e-19 Lung function (FEV1/FVC); CRC cis rs28386778 0.897 rs4968662 chr17:61834537 A/G cg23090583 chr17:61904693 PSMC5;FTSJ3 1.04 20.64 0.75 2.54e-61 Prudent dietary pattern; CRC cis rs6598955 0.585 rs11577098 chr1:26602525 C/T cg04990556 chr1:26633338 UBXN11 0.53 5.73 0.3 2.23e-8 Obesity-related traits; CRC trans rs7267979 0.966 rs2261790 chr20:25262789 T/C cg17903999 chr18:56338584 MALT1 -0.41 -6.88 -0.35 3.08e-11 Liver enzyme levels (alkaline phosphatase); CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg07393458 chr17:57297757 GDPD1 0.46 6.07 0.32 3.46e-9 Anxiety disorder; CRC cis rs919433 0.929 rs4850788 chr2:198182940 G/A cg03934865 chr2:198174659 NA -0.45 -8.08 -0.41 1.21e-14 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC cis rs7647973 0.626 rs1078341 chr3:49685592 A/G cg13072238 chr3:49761600 GMPPB -0.48 -5.76 -0.3 1.93e-8 Menarche (age at onset); CRC cis rs668210 0.894 rs1786171 chr11:65769809 G/C cg02202077 chr11:65769826 EIF1AD;BANF1 0.44 6.32 0.33 8.43e-10 Cerebrospinal fluid biomarker levels; CRC cis rs910316 1.000 rs4899544 chr14:75546556 C/T cg11812906 chr14:75593930 NEK9 0.61 9.7 0.47 1e-19 Height; CRC cis rs1882538 0.538 rs7803848 chr7:133108547 C/T cg10665199 chr7:133106180 EXOC4 0.59 9.24 0.45 3.18e-18 Intelligence (multi-trait analysis); CRC cis rs9911578 1.000 rs2531734 chr17:56550804 T/C cg12560992 chr17:57184187 TRIM37 -0.9 -16.49 -0.67 5.75e-45 Intelligence (multi-trait analysis); CRC cis rs10876993 0.890 rs12302350 chr12:58062589 T/G cg18357645 chr12:58087776 OS9 0.56 7.69 0.39 1.77e-13 Celiac disease or Rheumatoid arthritis; CRC cis rs524281 0.773 rs2017969 chr11:66039032 G/A cg14036092 chr11:66035641 RAB1B -0.56 -6.13 -0.32 2.56e-9 Electroencephalogram traits; CRC trans rs559356 0.519 rs604721 chr3:34839735 T/C cg19071035 chr6:20404090 E2F3 0.46 6.13 0.32 2.53e-9 Cognitive function; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg10870055 chr5:43484146 C5orf28 0.46 5.98 0.31 5.78e-9 Thyroid stimulating hormone; CRC cis rs2857891 0.695 rs2248341 chr11:6984677 A/T cg04053776 chr11:6947353 ZNF215 0.4 6.22 0.32 1.49e-9 Response to cytadine analogues (cytosine arabinoside); CRC cis rs76878669 0.561 rs55998145 chr11:66152586 A/G cg18002602 chr11:66138449 SLC29A2 0.29 6.19 0.32 1.84e-9 Educational attainment (years of education); CRC cis rs6543140 0.964 rs1523206 chr2:103070175 A/T cg04239558 chr2:103089729 SLC9A4 0.37 6.61 0.34 1.53e-10 Blood protein levels; CRC cis rs2243480 1.000 rs7795242 chr7:65390094 T/C cg12463550 chr7:65579703 CRCP 0.63 6.04 0.32 4.17e-9 Diabetic kidney disease; CRC cis rs2952156 0.920 rs732084 chr17:37834357 A/C cg20243544 chr17:37824526 PNMT 0.54 8.76 0.43 1.07e-16 Asthma; CRC cis rs478304 0.934 rs509206 chr11:65493807 C/T cg27068330 chr11:65405492 SIPA1 0.45 6.53 0.34 2.57e-10 Acne (severe); CRC cis rs2635047 0.967 rs7242978 chr18:44633424 G/T cg19077165 chr18:44547161 KATNAL2 0.53 8.1 0.41 1.11e-14 Educational attainment; CRC cis rs4664293 0.625 rs6713600 chr2:160563070 T/C cg08347373 chr2:160653686 CD302 0.39 6.53 0.34 2.44e-10 Monocyte percentage of white cells; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg24580185 chr2:160143534 WDSUB1 0.46 6.37 0.33 6.44e-10 Response to antipsychotic treatment; CRC cis rs17253792 0.822 rs78261053 chr14:56061784 C/T cg01858014 chr14:56050164 KTN1 -0.85 -6.72 -0.35 7.81e-11 Putamen volume; CRC cis rs6912958 1.000 rs6933587 chr6:88175577 T/G cg12350822 chr6:88032061 C6orf162;GJB7 -0.33 -6.29 -0.33 9.99e-10 Monocyte percentage of white cells; CRC cis rs6499255 1.000 rs11075734 chr16:69801397 G/T cg15192750 chr16:69999425 NA 0.54 7.13 0.37 6.25e-12 IgE levels; CRC cis rs17253792 0.822 rs13379340 chr14:56050346 C/G cg01858014 chr14:56050164 KTN1 -0.89 -7.94 -0.4 3.15e-14 Putamen volume; CRC cis rs4523957 0.893 rs12950555 chr17:2156910 C/G cg16513277 chr17:2031491 SMG6 0.52 8.77 0.44 9.5e-17 Autism spectrum disorder or schizophrenia;Schizophrenia; CRC cis rs7312933 0.510 rs61942483 chr12:42499538 T/A cg01256987 chr12:42539512 GXYLT1 -0.64 -11.64 -0.54 1.8e-26 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CRC cis rs727563 0.594 rs5758408 chr22:42077737 A/C cg06634786 chr22:41940651 POLR3H 0.61 6.86 0.35 3.38e-11 Crohn's disease;Inflammatory bowel disease; CRC cis rs4925386 0.759 rs2427293 chr20:60925859 A/G cg24112000 chr20:60950667 NA 0.53 8.48 0.42 7.59e-16 Colorectal cancer;Colorectal cancer (SNP x SNP interaction); CRC cis rs8105895 0.935 rs10425828 chr19:22283077 A/G cg02657401 chr19:22469223 NA -0.35 -5.67 -0.3 3.06e-8 Body mass index (change over time); CRC cis rs514406 0.584 rs7548832 chr1:53193576 A/T cg24675658 chr1:53192096 ZYG11B -0.66 -10.27 -0.49 1.17e-21 Monocyte count; CRC cis rs9910055 0.529 rs408282 chr17:42182267 A/G cg19774624 chr17:42201019 HDAC5 0.44 5.81 0.3 1.51e-8 Total body bone mineral density; CRC cis rs12908161 1.000 rs35524990 chr15:85258203 T/C cg17507749 chr15:85114479 UBE2QP1 0.63 9.11 0.45 8.42e-18 Schizophrenia; CRC cis rs6570726 0.875 rs368744 chr6:145812622 A/G cg23711669 chr6:146136114 FBXO30 0.62 10.59 0.5 9.94e-23 Lobe attachment (rater-scored or self-reported); CRC cis rs4400599 0.569 rs10797058 chr1:154200704 T/C cg26808167 chr1:154192205 UBAP2L;C1orf43 -0.36 -5.71 -0.3 2.49e-8 Platelet distribution width; CRC cis rs10504229 0.861 rs67042991 chr8:58191749 G/C cg01721255 chr8:58191610 C8orf71 0.49 6.17 0.32 2e-9 Developmental language disorder (linguistic errors); CRC cis rs826838 0.935 rs980571 chr12:39127532 C/G cg26384229 chr12:38710491 ALG10B -0.65 -9.55 -0.47 2.98e-19 Heart rate; CRC cis rs4689592 0.619 rs2359011 chr4:7066052 T/G cg19539972 chr4:7069911 GRPEL1 0.76 9.82 0.48 3.95e-20 Monocyte percentage of white cells; CRC cis rs951366 0.966 rs11240565 chr1:205722958 C/T cg07157834 chr1:205819609 PM20D1 -0.4 -5.67 -0.3 3.06e-8 Menarche (age at onset); CRC cis rs1153858 1.000 rs4775895 chr15:45617957 T/A cg10760299 chr15:45669010 GATM 0.53 8.13 0.41 8.58e-15 Homoarginine levels; CRC cis rs2932538 0.922 rs12125361 chr1:113144779 C/T cg22162597 chr1:113214053 CAPZA1 0.73 10.37 0.5 5.39e-22 Systolic blood pressure;Diastolic blood pressure;Hypertension;Blood pressure; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg09891106 chr20:33292075 TP53INP2 0.46 6.61 0.34 1.55e-10 Intelligence (multi-trait analysis); CRC cis rs501120 0.584 rs61857486 chr10:44719361 A/G cg09554077 chr10:44749378 NA 0.65 7.29 0.37 2.37e-12 Coronary artery disease;Coronary heart disease; CRC cis rs6500602 0.701 rs6500614 chr16:4573938 A/G cg06139259 chr16:4526053 HMOX2;NMRAL1 0.52 6.71 0.35 8.39e-11 Schizophrenia; CRC cis rs832540 0.931 rs832399 chr5:56222358 A/T cg18230493 chr5:56204884 C5orf35 -0.4 -5.96 -0.31 6.49e-9 Coronary artery disease; CRC cis rs4973397 0.686 rs10933370 chr2:232289960 C/A cg13347044 chr2:232276743 NA 0.39 5.79 0.3 1.62e-8 Anti-saccade response; CRC cis rs9894429 0.816 rs9747093 chr17:79584280 G/A cg18240062 chr17:79603768 NPLOC4 0.56 9.33 0.46 1.61e-18 Eye color traits; CRC cis rs477895 1.000 rs7939107 chr11:64034773 C/T cg04317338 chr11:64019027 PLCB3 0.61 6.44 0.33 4.22e-10 Mean platelet volume; CRC cis rs9359856 0.564 rs10484885 chr6:90395016 A/G cg13799429 chr6:90582589 CASP8AP2 -0.76 -7.74 -0.39 1.27e-13 Bipolar disorder; CRC cis rs58688157 0.705 rs12800061 chr11:587425 C/A cg01842473 chr11:617407 IRF7;MUPCDH -0.55 -6.39 -0.33 5.62e-10 Systemic lupus erythematosus; CRC cis rs2739330 0.734 rs2000467 chr22:24241533 C/T cg24846343 chr22:24311635 DDTL -0.74 -11.63 -0.54 2.1e-26 Liver enzyme levels (gamma-glutamyl transferase); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg24080313 chr3:55522631 WNT5A 0.33 6.73 0.35 7.4e-11 Intelligence (multi-trait analysis); CRC cis rs6502050 0.835 rs7219180 chr17:80079968 C/G cg02741985 chr17:80059408 CCDC57 -0.44 -7.17 -0.37 4.96e-12 Life satisfaction; CRC trans rs10506458 0.915 rs79133015 chr12:63396838 G/A cg03429785 chr15:59498649 MYO1E;LDHAL6B -1.43 -21.56 -0.77 6.79e-65 Hemostatic factors and hematological phenotypes; CRC cis rs3812049 0.826 rs6860245 chr5:127367998 G/C cg25462716 chr5:127418816 SLC12A2;FLJ33630 -0.78 -9.39 -0.46 1.02e-18 Lymphocyte counts;Red cell distribution width; CRC cis rs651907 0.557 rs3094295 chr3:101401995 T/C cg12386194 chr3:101231763 SENP7 0.51 7.32 0.37 1.97e-12 Colorectal cancer; CRC cis rs7208859 0.623 rs7220289 chr17:29103762 G/T cg13385521 chr17:29058706 SUZ12P 0.75 8.56 0.43 4.48e-16 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs1552244 1.000 rs68067759 chr3:10150535 T/C cg16606324 chr3:10149918 C3orf24 0.72 9.58 0.47 2.4e-19 Alzheimer's disease; CRC cis rs4713118 0.699 rs200978 chr6:27853168 C/G cg12273811 chr6:28175739 NA 0.59 7.68 0.39 1.81e-13 Parkinson's disease; CRC cis rs514406 0.800 rs7548519 chr1:53294473 A/G cg08859206 chr1:53392774 SCP2 -0.46 -7.46 -0.38 7.73e-13 Monocyte count; CRC cis rs4253772 0.637 rs9627295 chr22:46650100 C/T cg24881330 chr22:46731750 TRMU 0.56 6.6 0.34 1.61e-10 LDL cholesterol;Cholesterol, total; CRC cis rs6570726 0.791 rs9373466 chr6:145912016 T/C cg23711669 chr6:146136114 FBXO30 0.68 11.28 0.53 3.51e-25 Lobe attachment (rater-scored or self-reported); CRC cis rs801193 0.591 rs2707839 chr7:66193084 A/G cg12463550 chr7:65579703 CRCP 0.45 6.22 0.32 1.49e-9 Aortic root size; CRC cis rs9902453 0.808 rs56088359 chr17:28173659 A/G cg26525008 chr17:28256777 EFCAB5;SSH2 0.59 8.73 0.43 1.26e-16 Coffee consumption (cups per day); CRC cis rs1218582 0.772 rs7528532 chr1:154874440 C/T cg24250549 chr1:154909240 PMVK 0.65 11.29 0.53 3.2e-25 Prostate cancer; CRC cis rs9443189 0.813 rs3798439 chr6:76566734 T/G cg01950844 chr6:76311363 SENP6 -0.62 -7.42 -0.38 1.01e-12 Prostate cancer; CRC cis rs9311474 0.508 rs11720243 chr3:52618018 T/C cg05573699 chr3:52720067 GNL3;PBRM1 -0.47 -6.9 -0.36 2.76e-11 Electroencephalogram traits; CRC cis rs2976388 0.609 rs2717550 chr8:143787808 T/A cg05569086 chr8:143859399 LYNX1 0.4 6.93 0.36 2.2e-11 Urinary tract infection frequency; CRC trans rs617791 0.530 rs55947178 chr11:65754230 G/A cg17712092 chr4:129076599 LARP1B -0.47 -6.7 -0.35 9.13e-11 Breast cancer; CRC cis rs853679 0.517 rs56310871 chr6:28044482 A/G cg02683197 chr6:28174875 NA 0.79 9.73 0.47 8.12e-20 Depression; CRC cis rs875971 0.516 rs6945322 chr7:65336056 T/C cg05627663 chr7:65219948 SNORA22;CCT6P1 0.5 7.48 0.38 6.79e-13 Aortic root size; CRC cis rs861020 0.677 rs12723578 chr1:210032392 G/A cg05527609 chr1:210001259 C1orf107 -1.06 -13.33 -0.59 1.03e-32 Orofacial clefts; CRC cis rs7605827 0.930 rs11684395 chr2:15530870 A/G cg19274914 chr2:15703543 NA 0.39 5.77 0.3 1.86e-8 Educational attainment (years of education); CRC cis rs1183201 0.505 rs1165201 chr6:25874823 A/C cg07061783 chr6:25882402 NA -0.5 -6.69 -0.35 9.4e-11 Uric acid levels; CRC cis rs7635838 0.617 rs346076 chr3:11292682 A/G cg00170343 chr3:11313890 ATG7 -0.56 -8.75 -0.43 1.13e-16 HDL cholesterol; CRC cis rs870825 0.929 rs72689256 chr4:185590174 C/T cg07424746 chr4:185654737 MLF1IP -0.6 -5.91 -0.31 8.71e-9 Blood protein levels; CRC trans rs10982213 0.830 rs2274163 chr9:117188714 C/T cg23197860 chr4:113558550 LARP7;C4orf21 0.4 5.97 0.31 6.09e-9 Interleukin-6 levels; CRC cis rs6831352 0.918 rs28987097 chr4:100049579 C/T cg13256891 chr4:100009986 ADH5 -0.66 -8.89 -0.44 4.04e-17 Alcohol dependence; CRC cis rs3889199 1.000 rs6668886 chr1:59656884 C/A cg25881383 chr1:59680599 NA -0.37 -5.98 -0.31 5.87e-9 Pulse pressure; CRC cis rs9409565 0.586 rs7041103 chr9:97067654 A/G cg04523069 chr9:97136363 HIATL1 -0.43 -6.0 -0.31 5.28e-9 Colorectal cancer (alcohol consumption interaction); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg03533382 chr5:126853128 PRRC1 0.47 6.76 0.35 6.22e-11 Response to antipsychotic treatment; CRC trans rs208520 1.000 rs72882086 chr6:66976671 G/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.89 10.97 0.52 4.54e-24 Exhaled nitric oxide output; CRC cis rs1799949 1.000 rs16940 chr17:41245237 A/G cg19454999 chr17:41278357 BRCA1;NBR2 0.54 8.28 0.42 3.09e-15 Menopause (age at onset); CRC cis rs2404602 0.692 rs4360890 chr15:77173295 G/A cg03037974 chr15:76606532 NA 0.68 11.55 0.54 4.06e-26 Blood metabolite levels; CRC cis rs727505 0.954 rs55768077 chr7:124663216 A/G cg23710748 chr7:124431027 NA -0.78 -13.7 -0.6 4.15e-34 Lewy body disease; CRC cis rs6429082 0.510 rs2789369 chr1:235503515 A/G cg26050004 chr1:235667680 B3GALNT2 0.4 5.86 0.31 1.11e-8 Adiposity; CRC cis rs9297145 1.000 rs10953280 chr7:98763405 A/G cg05967295 chr7:98741636 SMURF1 -1.01 -17.72 -0.7 8.48e-50 Crohn's disease;Inflammatory bowel disease;Ulcerative colitis; CRC cis rs6840360 0.642 rs11726254 chr4:152438850 G/C cg09659197 chr4:152720779 NA 0.33 6.66 0.34 1.14e-10 Intelligence (multi-trait analysis); CRC cis rs11166927 0.524 rs2035088 chr8:140831403 A/G cg16909799 chr8:140841666 TRAPPC9 -0.44 -6.54 -0.34 2.41e-10 Pediatric non-alcoholic fatty liver disease activity score; CRC cis rs939658 0.626 rs11636901 chr15:79446292 T/C cg17916960 chr15:79447300 NA -0.38 -6.18 -0.32 1.92e-9 Refractive error; CRC cis rs12368653 0.701 rs238517 chr12:58117737 T/G cg00677455 chr12:58241039 CTDSP2 -0.41 -5.86 -0.31 1.11e-8 Multiple sclerosis; CRC cis rs9858542 0.537 rs35869135 chr3:49359102 A/G cg00383909 chr3:49044727 WDR6 0.56 5.92 0.31 7.97e-9 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs7666738 0.830 rs7663924 chr4:99037679 A/G cg17366294 chr4:99064904 C4orf37 -0.42 -7.08 -0.36 8.72e-12 Colonoscopy-negative controls vs population controls; CRC trans rs2727020 0.729 rs10742932 chr11:49173234 T/C cg15704280 chr7:45808275 SEPT13 -0.8 -13.4 -0.59 5.88e-33 Coronary artery disease; CRC cis rs6963495 0.818 rs73192145 chr7:105203628 A/C cg02135003 chr7:105160482 PUS7 -0.96 -12.75 -0.58 1.54e-30 Bipolar disorder (body mass index interaction); CRC cis rs7580658 0.864 rs10928761 chr2:128003247 C/T cg09760422 chr2:128146352 NA -0.3 -5.83 -0.31 1.31e-8 Protein C levels; CRC trans rs916888 0.610 rs199529 chr17:44837217 A/C cg22433210 chr17:43662623 NA 0.8 8.34 0.42 2.06e-15 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs6693567 0.565 rs1260407 chr1:150306125 T/C cg15654264 chr1:150340011 RPRD2 0.37 5.81 0.31 1.46e-8 Migraine; CRC cis rs2739330 0.753 rs4822452 chr22:24254363 C/T cg11060661 chr22:24314208 DDT;DDTL 0.47 8.25 0.41 3.85e-15 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs1499614 1.000 rs1882655 chr7:66147057 T/C cg18252515 chr7:66147081 NA 1.25 14.86 0.63 1.38e-38 Gout; CRC cis rs7615952 0.599 rs2333408 chr3:125732098 G/A cg15145296 chr3:125709740 NA -0.56 -7.15 -0.37 5.75e-12 Blood pressure (smoking interaction); CRC cis rs4481887 0.821 rs7515408 chr1:248425738 C/T cg13385794 chr1:248469461 NA 0.4 6.75 0.35 6.58e-11 Common traits (Other); CRC cis rs60843830 1.000 rs60484953 chr2:221560 G/A cg25945732 chr2:264204 ACP1;SH3YL1 0.74 11.7 0.54 1.12e-26 Spherical equivalent (joint analysis main effects and education interaction); CRC cis rs11098499 0.687 rs71610270 chr4:120287436 A/G cg24375607 chr4:120327624 NA 0.48 7.31 0.37 2.04e-12 Corneal astigmatism; CRC cis rs11229555 0.874 rs11605297 chr11:58296806 G/A cg15696309 chr11:58395628 NA -0.95 -12.65 -0.57 3.73e-30 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; CRC cis rs7552404 0.924 rs1858536 chr1:76161595 G/T cg10523679 chr1:76189770 ACADM 0.93 14.17 0.62 6.79e-36 Blood metabolite levels;Acylcarnitine levels; CRC cis rs7666738 0.830 rs11944107 chr4:98931638 G/C cg17366294 chr4:99064904 C4orf37 0.43 7.32 0.37 1.95e-12 Colonoscopy-negative controls vs population controls; CRC trans rs1814175 0.817 rs7109440 chr11:49966296 C/T cg21153622 chr11:89784906 NA -0.38 -6.07 -0.32 3.44e-9 Height; CRC cis rs4665809 1.000 rs6546727 chr2:26275282 C/T cg26119090 chr2:26468346 HADHA;HADHB -0.62 -7.95 -0.4 2.95e-14 Gut microbiome composition (summer); CRC cis rs916888 0.610 rs199436 chr17:44789285 C/T cg01570182 chr17:44337453 NA -0.76 -9.68 -0.47 1.12e-19 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs10883723 0.737 rs11191312 chr10:104278601 T/C cg04362960 chr10:104952993 NT5C2 -0.42 -5.68 -0.3 2.94e-8 Allergic disease (asthma, hay fever or eczema); CRC cis rs478304 0.654 rs1074155 chr11:65458197 C/T cg27068330 chr11:65405492 SIPA1 0.67 10.0 0.48 9.68e-21 Acne (severe); CRC cis rs1348850 0.626 rs1901825 chr2:178225331 A/T cg02961200 chr2:178257176 LOC100130691;AGPS 0.45 6.53 0.34 2.49e-10 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs7811142 1.000 rs7803454 chr7:99991548 C/T cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.72 9.1 0.45 8.8e-18 Platelet count; CRC trans rs11039798 1.000 rs12223271 chr11:48417420 G/C cg15704280 chr7:45808275 SEPT13 0.64 6.21 0.32 1.62e-9 Axial length; CRC cis rs1223397 0.938 rs35549743 chr6:13294354 C/T cg07912922 chr6:13274314 PHACTR1 0.54 6.44 0.33 4.32e-10 Blood pressure; CRC cis rs10927875 0.830 rs1763610 chr1:16335527 C/G cg21385522 chr1:16154831 NA -0.6 -7.79 -0.39 8.87e-14 Dilated cardiomyopathy; CRC cis rs10504229 0.683 rs2318144 chr8:58114743 G/A cg11062466 chr8:58055876 NA 0.54 6.79 0.35 5.24e-11 Developmental language disorder (linguistic errors); CRC cis rs4666002 0.789 rs13023094 chr2:27910706 G/T cg27432699 chr2:27873401 GPN1 -0.53 -6.82 -0.35 4.26e-11 Phospholipid levels (plasma); CRC cis rs10504229 1.000 rs67546820 chr8:58168567 G/A cg01721255 chr8:58191610 C8orf71 0.45 5.76 0.3 1.96e-8 Developmental language disorder (linguistic errors); CRC cis rs16975963 0.644 rs73033129 chr19:38080535 G/T cg15135657 chr19:38346511 NA -0.46 -6.28 -0.33 1.09e-9 Longevity; CRC cis rs769267 0.931 rs15622 chr19:19468734 G/A cg02546618 chr19:19431379 KIAA0892;SF4 -0.48 -6.54 -0.34 2.37e-10 Tonsillectomy; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg22786506 chr11:116969293 SIK3 0.42 5.97 0.31 6.31e-9 Anxiety disorder; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg20817853 chr17:75084718 SCARNA16;C17orf86 0.49 6.92 0.36 2.38e-11 Response to antipsychotic treatment; CRC cis rs4713118 0.523 rs2179096 chr6:27665920 C/T cg25164649 chr6:28176230 NA 0.49 7.06 0.36 1.02e-11 Parkinson's disease; CRC cis rs73198271 0.531 rs3748142 chr8:8655355 G/A cg01851573 chr8:8652454 MFHAS1 0.51 6.27 0.33 1.15e-9 Bone ultrasound measurement (broadband ultrasound attenuation); CRC cis rs57221529 0.766 rs12519763 chr5:559145 C/T cg16447950 chr5:562315 NA -0.84 -11.5 -0.54 6.14e-26 Lung disease severity in cystic fibrosis; CRC cis rs853679 0.517 rs17711344 chr6:28077602 A/G cg15845792 chr6:28175446 NA -1.02 -13.73 -0.6 3.27e-34 Depression; CRC cis rs7224685 0.501 rs2054038 chr17:4014391 A/C cg11204139 chr17:3907470 NA 0.64 11.14 0.52 1.11e-24 Type 2 diabetes; CRC cis rs9487051 0.676 rs7775206 chr6:109597222 A/G cg21918786 chr6:109611834 NA -0.42 -7.46 -0.38 7.91e-13 Reticulocyte fraction of red cells; CRC cis rs1153858 1.000 rs16942000 chr15:45633003 C/T cg14582100 chr15:45693742 SPATA5L1 0.28 5.82 0.31 1.43e-8 Homoarginine levels; CRC cis rs11098499 0.954 rs9993199 chr4:120392873 A/G cg09307838 chr4:120376055 NA -0.69 -11.0 -0.52 3.42e-24 Corneal astigmatism; CRC cis rs4660306 0.961 rs945179 chr1:45992460 A/G cg03123370 chr1:45965343 CCDC163P;MMACHC 0.57 8.06 0.41 1.4e-14 Homocysteine levels; CRC cis rs9905704 0.647 rs33922512 chr17:57114148 C/G cg12560992 chr17:57184187 TRIM37 -0.65 -10.1 -0.49 4.54e-21 Testicular germ cell tumor; CRC trans rs9341835 0.584 rs2622307 chr6:64152049 G/C cg13657004 chr13:50234944 EBPL -0.37 -6.38 -0.33 6.03e-10 Schizophrenia; CRC cis rs453193 0.966 rs658243 chr2:8446695 G/T cg12167548 chr2:8464763 NA 0.32 5.93 0.31 7.69e-9 Granulocyte percentage of myeloid white cells; CRC trans rs1005277 0.579 rs2472181 chr10:38386764 T/C cg17830980 chr10:43048298 ZNF37B -0.6 -9.96 -0.48 1.3e-20 Extrinsic epigenetic age acceleration; CRC cis rs2204008 0.749 rs10880692 chr12:38592918 C/G cg13010199 chr12:38710504 ALG10B -0.45 -5.74 -0.3 2.15e-8 Bladder cancer; CRC cis rs6547741 0.967 rs4665986 chr2:27755168 G/A cg27432699 chr2:27873401 GPN1 0.75 13.34 0.59 9.27e-33 Oral cavity cancer; CRC trans rs10983614 1.000 rs7867776 chr9:120072627 A/G cg23018242 chr22:31608245 LIMK2 0.43 6.14 0.32 2.38e-9 Survival in pancreatic cancer; CRC cis rs4713118 0.955 rs9380012 chr6:27684654 A/G cg26587870 chr6:27730563 NA -0.42 -6.28 -0.33 1.05e-9 Parkinson's disease; CRC cis rs360798 0.532 rs360800 chr2:62954326 C/T cg17519650 chr2:63277830 OTX1 -0.47 -6.39 -0.33 5.59e-10 Coronary artery disease; CRC cis rs7618915 0.547 rs10780035 chr3:52764624 C/T cg11645453 chr3:52864694 ITIH4 0.36 6.31 0.33 8.84e-10 Bipolar disorder; CRC cis rs711830 0.965 rs6755777 chr2:177043226 T/G cg13092806 chr2:177043255 NA 0.75 9.56 0.47 2.82e-19 Serous invasive ovarian cancer;Epithelial ovarian cancer;Invasive epithelial ovarian cancer;Mucinous ovarian carcinoma;Low-grade serous and serous borderline ovarian cancer;Serous borderline ovarian cancer;High-grade serous ovarian cancer; CRC cis rs910316 1.000 rs12589876 chr14:75544189 G/A cg03030879 chr14:75389066 RPS6KL1 -0.45 -6.95 -0.36 1.95e-11 Height; CRC cis rs2180341 0.538 rs11154402 chr6:127711932 C/A cg27446573 chr6:127587934 RNF146 0.48 6.98 0.36 1.68e-11 Breast cancer; CRC trans rs12310956 0.532 rs10844720 chr12:33987859 G/T cg26384229 chr12:38710491 ALG10B 0.47 6.28 0.33 1.06e-9 Morning vs. evening chronotype; CRC cis rs11676348 0.846 rs13009946 chr2:219007752 A/C cg04731861 chr2:219085781 ARPC2 0.27 5.7 0.3 2.63e-8 Ulcerative colitis; CRC trans rs3942852 0.955 rs4752897 chr11:48136990 C/T cg03929089 chr4:120376271 NA -0.55 -6.59 -0.34 1.76e-10 Acute lymphoblastic leukemia (childhood); CRC cis rs4666002 0.750 rs13021208 chr2:27901728 C/T cg27432699 chr2:27873401 GPN1 0.55 7.0 0.36 1.47e-11 Phospholipid levels (plasma); CRC cis rs7772486 0.590 rs1890170 chr6:146071839 G/C cg23711669 chr6:146136114 FBXO30 -0.63 -9.19 -0.45 4.73e-18 Lobe attachment (rater-scored or self-reported); CRC cis rs10991814 1.000 rs76067199 chr9:93959395 C/T cg14446406 chr9:93919335 NA 0.56 6.05 0.32 4e-9 Neutrophil percentage of granulocytes; CRC cis rs7617773 0.539 rs11706939 chr3:48383992 G/T cg11946769 chr3:48343235 NME6 0.61 8.21 0.41 5.26e-15 Coronary artery disease; CRC cis rs12701220 0.520 rs7803208 chr7:1162084 C/T cg26769984 chr7:1090371 C7orf50 0.38 5.82 0.31 1.4e-8 Bronchopulmonary dysplasia; CRC cis rs826838 0.904 rs1554550 chr12:39208889 G/A cg26384229 chr12:38710491 ALG10B 0.69 9.25 0.45 3e-18 Heart rate; CRC cis rs10781543 0.775 rs10870194 chr9:139327034 A/G cg14019695 chr9:139328340 INPP5E 0.4 5.88 0.31 9.88e-9 Monocyte percentage of white cells; CRC cis rs600231 0.708 rs661403 chr11:65242478 A/G cg17120908 chr11:65337727 SSSCA1 -0.56 -8.33 -0.42 2.14e-15 Bone mineral density; CRC cis rs72781680 0.848 rs2339926 chr2:24045734 C/G cg08917208 chr2:24149416 ATAD2B 0.9 8.87 0.44 4.67e-17 Lymphocyte counts; CRC cis rs2075371 0.501 rs1643051 chr7:134025372 A/G cg20476274 chr7:133979776 SLC35B4 -0.54 -8.23 -0.41 4.56e-15 Mean platelet volume; CRC cis rs7613875 0.641 rs6793528 chr3:50100188 C/A cg05623727 chr3:50126028 RBM5 -0.57 -9.85 -0.48 3.07e-20 Body mass index; CRC cis rs10751667 0.560 rs7924794 chr11:962745 A/T cg23136738 chr11:925521 AP2A2 -0.41 -6.87 -0.35 3.15e-11 Alzheimer's disease (late onset); CRC trans rs1814175 0.500 rs1825677 chr11:49233099 T/G cg15704280 chr7:45808275 SEPT13 -0.62 -8.96 -0.44 2.47e-17 Height; CRC cis rs4654899 0.733 rs10799678 chr1:21322785 C/T cg02927042 chr1:21476669 EIF4G3 -0.4 -6.27 -0.33 1.12e-9 Superior frontal gyrus grey matter volume; CRC cis rs1005277 0.579 rs2504148 chr10:38400788 A/G cg25517755 chr10:38738941 LOC399744 -0.45 -6.56 -0.34 2.07e-10 Extrinsic epigenetic age acceleration; CRC cis rs11098499 0.691 rs9996494 chr4:120238880 C/A cg24375607 chr4:120327624 NA 0.48 7.64 0.39 2.41e-13 Corneal astigmatism; CRC cis rs7932354 0.502 rs57323109 chr11:47193367 T/G cg03339077 chr11:47165057 C11orf49 -0.46 -6.28 -0.33 1.06e-9 Bone mineral density (hip);Bone mineral density; CRC cis rs9287719 0.624 rs10199635 chr2:10726640 T/C cg00105475 chr2:10696890 NA 0.44 7.0 0.36 1.43e-11 Prostate cancer; CRC trans rs8073060 0.559 rs72829925 chr17:34049778 C/A cg19694781 chr19:47549865 TMEM160 1.08 14.83 0.63 1.78e-38 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; CRC cis rs7727544 0.618 rs2631367 chr5:131705458 C/G cg04518342 chr5:131593106 PDLIM4 -0.33 -5.75 -0.3 2.03e-8 Blood metabolite levels; CRC cis rs875971 0.862 rs801206 chr7:66021966 C/G cg12463550 chr7:65579703 CRCP -0.47 -6.46 -0.34 3.85e-10 Aortic root size; CRC cis rs10504229 0.953 rs17805380 chr8:58171128 C/A cg01721255 chr8:58191610 C8orf71 0.49 6.17 0.32 2e-9 Developmental language disorder (linguistic errors); CRC cis rs1223397 0.938 rs3817741 chr6:13279507 A/G cg07912922 chr6:13274314 PHACTR1 -0.47 -5.99 -0.31 5.6e-9 Blood pressure; CRC cis rs11785400 0.642 rs4256574 chr8:143725705 C/T cg24634471 chr8:143751801 JRK 0.51 7.08 0.36 8.81e-12 Schizophrenia; CRC trans rs12478296 0.786 rs13409307 chr2:242995499 G/C cg06834434 chr14:75079333 LTBP2 0.57 6.88 0.35 3.1e-11 Obesity-related traits; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg22292364 chr19:50180326 PRMT1 0.48 6.16 0.32 2.14e-9 Thyroid stimulating hormone; CRC cis rs881375 0.702 rs3761847 chr9:123690239 G/A cg09419670 chr9:123605666 PSMD5;LOC253039 0.45 6.85 0.35 3.59e-11 Rheumatoid arthritis; CRC cis rs9814567 1.000 rs9856693 chr3:134306913 T/C cg06109529 chr3:134205091 CEP63;ANAPC13 -0.8 -11.7 -0.54 1.13e-26 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs2243480 1.000 rs1701750 chr7:65467145 T/C cg12463550 chr7:65579703 CRCP 0.65 6.2 0.32 1.67e-9 Diabetic kidney disease; CRC cis rs887829 0.667 rs7577677 chr2:234590616 C/A cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.42 -6.32 -0.33 8.45e-10 Metabolic traits;Bilirubin levels;Cholelithiasis-related traits in sickle cell anemia;Metabolite levels;Total bilirubin levels in HIV-1 infection;Serum metabolite levels;Blood metabolite levels; CRC cis rs4843747 0.708 rs11866437 chr16:88072279 A/G cg03395651 chr16:88107091 BANP -0.55 -7.53 -0.38 4.98e-13 Menopause (age at onset); CRC cis rs7208859 0.573 rs60724269 chr17:29113273 G/T cg01831904 chr17:28903510 LRRC37B2 -0.62 -6.41 -0.33 5.13e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC trans rs9291683 0.620 rs4383618 chr4:10125151 T/C cg26043149 chr18:55253948 FECH -0.58 -9.01 -0.44 1.76e-17 Bone mineral density; CRC cis rs763014 0.932 rs35067229 chr16:649638 T/C cg18653534 chr16:772142 FAM173A -0.35 -5.61 -0.3 4.33e-8 Height; CRC cis rs12760731 0.565 rs7550699 chr1:178209584 T/G cg00404053 chr1:178313656 RASAL2 1.11 11.45 0.53 8.6e-26 Obesity-related traits; CRC cis rs4965869 0.866 rs4965866 chr15:101975931 C/T cg12371147 chr15:101978424 PCSK6 -0.41 -5.8 -0.3 1.58e-8 Platelet-derived growth factor BB levels; CRC trans rs8073060 0.586 rs4796098 chr17:33913436 T/C cg19694781 chr19:47549865 TMEM160 1.03 14.37 0.62 1.16e-36 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; CRC cis rs7811142 1.000 rs7809801 chr7:100072031 T/C cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.75 10.37 0.5 5.39e-22 Platelet count; CRC cis rs514406 0.929 rs1672908 chr1:53340885 A/G cg24675658 chr1:53192096 ZYG11B -0.58 -8.61 -0.43 3.14e-16 Monocyte count; CRC cis rs394563 0.726 rs6942381 chr6:149662991 G/C cg07828024 chr6:149772892 ZC3H12D 0.49 9.19 0.45 4.46e-18 Dupuytren's disease; CRC trans rs62295889 0.602 rs60391312 chr4:12537820 C/G cg03490839 chr16:73082051 ZFHX3 0.58 6.06 0.32 3.82e-9 Obesity-related traits; CRC cis rs853679 0.542 rs9393892 chr6:28081394 A/G cg12273811 chr6:28175739 NA 0.72 9.09 0.45 9.21e-18 Depression; CRC trans rs2303319 0.504 rs1006427 chr2:162592328 T/C cg11326919 chr17:43324904 LOC100133991 -0.64 -5.97 -0.31 5.99e-9 Cognitive function; CRC cis rs9322193 0.923 rs14314 chr6:150141531 A/C cg05861140 chr6:150128134 PCMT1 -0.44 -7.0 -0.36 1.48e-11 Lung cancer; CRC cis rs9914988 0.565 rs34039488 chr17:27320232 G/A cg16670446 chr17:27188758 MIR451;MIR144 0.49 6.58 0.34 1.8e-10 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs13256369 0.708 rs11249886 chr8:8562021 T/A cg06671706 chr8:8559999 CLDN23 0.61 9.05 0.45 1.3e-17 Obesity-related traits; CRC trans rs2797160 0.684 rs1832937 chr6:125985934 A/G cg05039488 chr6:79577232 IRAK1BP1 0.51 7.58 0.39 3.6e-13 Endometrial cancer; CRC cis rs7959452 0.640 rs10878957 chr12:69699638 G/C cg14784868 chr12:69753453 YEATS4 0.76 12.35 0.56 4.59e-29 Blood protein levels; CRC cis rs4332037 0.539 rs62444881 chr7:2052318 C/T cg13880726 chr7:1868755 MAD1L1 -0.47 -5.68 -0.3 3.01e-8 Bipolar disorder; CRC cis rs10927875 0.864 rs6674071 chr1:16144855 G/C cg21385522 chr1:16154831 NA -0.91 -11.58 -0.54 2.99e-26 Dilated cardiomyopathy; CRC cis rs2439831 0.850 rs60883262 chr15:44076503 T/C cg02155558 chr15:43621948 ADAL;LCMT2 0.68 7.47 0.38 7.38e-13 Lung cancer in ever smokers; CRC cis rs6693567 0.565 rs12731296 chr1:150411787 A/G cg15654264 chr1:150340011 RPRD2 0.42 6.25 0.33 1.29e-9 Migraine; CRC cis rs4268898 0.722 rs11680491 chr2:24416292 T/A cg06627628 chr2:24431161 ITSN2 0.48 7.11 0.37 7.17e-12 Asthma; CRC cis rs738322 0.935 rs4384 chr22:38572440 G/C cg17652424 chr22:38574118 PLA2G6 -0.21 -6.62 -0.34 1.47e-10 Cutaneous nevi; CRC cis rs6860806 0.507 rs274570 chr5:131713226 C/T cg12564285 chr5:131593104 PDLIM4 -0.46 -7.64 -0.39 2.36e-13 Breast cancer; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg18835942 chr20:306049 SOX12 0.48 6.89 0.36 2.9100000000000002e-11 Anxiety disorder; CRC cis rs3106136 0.967 rs7435106 chr4:95169772 T/A cg11021082 chr4:95130006 SMARCAD1 -0.46 -7.14 -0.37 5.88e-12 Capecitabine sensitivity; CRC trans rs2303319 0.504 rs56100249 chr2:162415157 T/C cg18122310 chr12:50236657 BCDIN3D -0.75 -6.23 -0.32 1.45e-9 Cognitive function; CRC cis rs2976388 0.573 rs1529865 chr8:143789171 C/T cg22687807 chr8:143858763 LYNX1 0.49 8.92 0.44 3.32e-17 Urinary tract infection frequency; CRC cis rs67311347 1.000 rs1466236 chr3:40462162 C/T cg09455208 chr3:40491958 NA 0.46 9.49 0.46 4.98e-19 Renal cell carcinoma; CRC cis rs9914988 0.943 rs9893782 chr17:27108132 C/T cg12682573 chr17:27188876 MIR451;MIR144 0.58 7.99 0.4 2.37e-14 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs1448094 0.817 rs10863108 chr12:86328249 C/T cg00310523 chr12:86230176 RASSF9 0.43 7.26 0.37 2.88e-12 Major depressive disorder; CRC cis rs3091242 0.933 rs10903129 chr1:25768937 A/G cg27572855 chr1:25598939 RHD 0.34 6.0 0.31 5.11e-9 Erythrocyte sedimentation rate; CRC trans rs877282 0.741 rs35865720 chr10:753022 G/A cg22713356 chr15:30763199 NA 1.17 13.24 0.59 2.19e-32 Uric acid levels; CRC cis rs6684514 1.000 rs12118238 chr1:156235221 G/A cg16558208 chr1:156270281 VHLL 0.62 9.66 0.47 1.32e-19 Mean corpuscular hemoglobin concentration;Glycated hemoglobin levels; CRC cis rs919433 0.929 rs10931779 chr2:198166825 A/G cg10820045 chr2:198174542 NA -0.58 -11.94 -0.55 1.53e-27 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC cis rs2732480 0.500 rs7966829 chr12:48615603 G/T cg04545296 chr12:48745243 ZNF641 0.32 5.69 0.3 2.78e-8 Hemoglobin concentration;Red blood cell count;Hematocrit; CRC cis rs11190604 1.000 rs1080698 chr10:102295114 G/T cg16342193 chr10:102329863 NA -0.39 -6.28 -0.33 1.06e-9 Palmitoleic acid (16:1n-7) levels; CRC cis rs6570726 0.935 rs365658 chr6:145844588 C/T cg05347473 chr6:146136440 FBXO30 0.38 6.13 0.32 2.58e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs4474465 0.646 rs7927503 chr11:78280606 G/T cg27205649 chr11:78285834 NARS2 0.54 7.1 0.36 7.95e-12 Alzheimer's disease (survival time); CRC cis rs4332037 0.851 rs28728306 chr7:1961814 C/A cg23378565 chr7:2036160 MAD1L1 -0.41 -5.81 -0.31 1.47e-8 Bipolar disorder; CRC cis rs801193 1.000 rs3857688 chr7:66127806 G/A cg18876405 chr7:65276391 NA -0.61 -10.75 -0.51 2.66e-23 Aortic root size; CRC cis rs4423214 0.959 rs12793224 chr11:71168710 G/A cg05163923 chr11:71159392 DHCR7 0.64 9.07 0.45 1.08e-17 Vitamin D levels; CRC cis rs9309473 1.000 rs62151652 chr2:73700131 A/C cg20560298 chr2:73613845 ALMS1 -0.45 -5.63 -0.3 3.95e-8 Metabolite levels; CRC cis rs651907 0.535 rs17412601 chr3:101499275 T/C cg12386194 chr3:101231763 SENP7 0.52 7.54 0.38 4.49e-13 Colorectal cancer; CRC cis rs78761021 0.720 rs874307 chr17:9798074 C/G cg26853458 chr17:9805074 RCVRN 0.43 7.89 0.4 4.53e-14 Type 2 diabetes; CRC trans rs801193 0.591 rs9986881 chr7:66173040 A/G cg02869306 chr7:64672164 INTS4L1 -0.38 -6.23 -0.32 1.46e-9 Aortic root size; CRC cis rs898097 0.690 rs12452304 chr17:80811659 G/A cg19046167 chr17:80928561 B3GNTL1 -0.42 -6.54 -0.34 2.32e-10 Breast cancer; CRC cis rs6860806 0.507 rs272882 chr5:131669161 G/T cg02033258 chr5:131593261 PDLIM4 0.37 6.38 0.33 6.02e-10 Breast cancer; CRC cis rs798554 0.718 rs1636247 chr7:2881917 A/G cg19717773 chr7:2847554 GNA12 -0.48 -6.78 -0.35 5.62e-11 Height; CRC cis rs4363385 0.791 rs4041401 chr1:152985629 A/G cg25856811 chr1:152973957 SPRR3 -0.24 -6.71 -0.35 8.48e-11 Inflammatory skin disease; CRC cis rs270601 0.739 rs1979981 chr5:131601720 G/A cg04518342 chr5:131593106 PDLIM4 0.52 9.68 0.47 1.19e-19 Acylcarnitine levels; CRC cis rs7107174 0.901 rs10899498 chr11:78124575 C/G cg12700464 chr11:78128424 GAB2 -0.48 -5.72 -0.3 2.33e-8 Testicular germ cell tumor; CRC cis rs453301 0.686 rs3989373 chr8:8911308 G/T cg06636001 chr8:8085503 FLJ10661 -0.5 -7.59 -0.39 3.43e-13 Joint mobility (Beighton score); CRC cis rs2404602 0.716 rs284895 chr15:76751225 C/G cg22467129 chr15:76604101 ETFA 0.44 7.33 0.37 1.74e-12 Blood metabolite levels; CRC cis rs12477438 0.798 rs4851179 chr2:99568774 G/T cg26064155 chr2:99771622 LIPT1;TSGA10 -0.76 -10.8 -0.51 1.82e-23 Chronic sinus infection; CRC cis rs2739330 0.627 rs9608219 chr22:24274119 G/C cg24846343 chr22:24311635 DDTL 0.76 12.64 0.57 3.87e-30 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs9368481 0.761 rs12661756 chr6:27003483 A/G cg10547057 chr6:26987810 LOC100270746;C6orf41 0.41 5.86 0.31 1.11e-8 Autism spectrum disorder or schizophrenia; CRC cis rs34172651 0.876 rs2112785 chr16:24781176 C/T cg06505273 chr16:24850292 NA 0.38 5.79 0.3 1.63e-8 Intelligence (multi-trait analysis); CRC cis rs2243480 1.000 rs4718269 chr7:65200778 C/G cg18252515 chr7:66147081 NA 1.09 12.58 0.57 6.71e-30 Diabetic kidney disease; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg17816495 chr19:19030203 DDX49;COPE -0.43 -6.59 -0.34 1.74e-10 Myopia (pathological); CRC cis rs1046896 0.731 rs8067667 chr17:80785875 A/G cg19500275 chr17:80737654 TBCD 0.52 7.04 0.36 1.1e-11 Glycated hemoglobin levels; CRC cis rs2635047 1.000 rs2277717 chr18:44702718 C/A cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.42 6.98 0.36 1.66e-11 Educational attainment; CRC cis rs6570726 0.557 rs403956 chr6:145829956 T/C cg05347473 chr6:146136440 FBXO30 0.48 7.09 0.36 8.17e-12 Lobe attachment (rater-scored or self-reported); CRC cis rs7113874 0.655 rs7945659 chr11:8529925 A/T cg02811074 chr11:8615871 STK33 -0.36 -6.0 -0.31 5.13e-9 Body mass index in physically active individuals;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs35110281 0.807 rs2838326 chr21:45014315 C/T cg04455712 chr21:45112962 RRP1B 0.38 7.32 0.37 1.9e-12 Mean corpuscular volume; CRC cis rs3818285 0.655 rs623980 chr10:111646147 C/T cg00817464 chr10:111662876 XPNPEP1 -0.67 -12.02 -0.55 7.57e-28 Superior crus of antihelix expression; CRC cis rs910316 0.664 rs2098252 chr14:75492732 T/C cg11812906 chr14:75593930 NEK9 0.59 9.27 0.46 2.54e-18 Height; CRC cis rs12479064 0.724 rs2305352 chr2:100015124 C/G cg26064155 chr2:99771622 LIPT1;TSGA10 -0.62 -7.74 -0.39 1.2e-13 Chronic sinus infection; CRC cis rs7605378 0.528 rs1704191 chr2:200816393 C/A cg17644776 chr2:200775616 C2orf69 0.46 7.34 0.37 1.73e-12 Osteoporosis; CRC cis rs7580658 0.895 rs62157549 chr2:128066007 A/G cg09760422 chr2:128146352 NA -0.29 -5.65 -0.3 3.56e-8 Protein C levels; CRC cis rs2739330 0.828 rs4820572 chr22:24250355 T/C cg16132339 chr22:24313637 DDTL;DDT 0.61 9.46 0.46 5.99e-19 Liver enzyme levels (gamma-glutamyl transferase); CRC trans rs2243480 1.000 rs160644 chr7:65558186 C/T cg10756647 chr7:56101905 PSPH 0.67 7.34 0.38 1.69e-12 Diabetic kidney disease; CRC cis rs2730245 0.528 rs1188954 chr7:158691417 G/A cg24397884 chr7:158709396 WDR60 0.77 11.27 0.53 3.83e-25 Height; CRC cis rs868036 0.756 rs2241421 chr15:68082825 G/A cg05925327 chr15:68127851 NA -0.31 -6.01 -0.31 4.97e-9 Restless legs syndrome; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg17428694 chr1:163291564 NUF2 0.39 6.06 0.32 3.67e-9 Liver disease severity in Alagille syndrome; CRC cis rs4808199 0.947 rs2163804 chr19:19575965 G/A cg03709012 chr19:19516395 GATAD2A 1.0 11.99 0.55 1.01e-27 Nonalcoholic fatty liver disease; CRC cis rs2243480 1.000 rs316329 chr7:65608416 A/C cg18252515 chr7:66147081 NA -1.21 -14.88 -0.63 1.17e-38 Diabetic kidney disease; CRC cis rs6502050 0.835 rs8081949 chr17:80117490 G/A cg25804541 chr17:80189381 SLC16A3 -0.3 -5.88 -0.31 9.84e-9 Life satisfaction; CRC cis rs6662572 0.906 rs11582058 chr1:46245423 A/G cg08644498 chr1:46502608 NA -0.45 -7.22 -0.37 3.54e-12 Blood protein levels; CRC cis rs6951245 1.000 rs111899361 chr7:1112348 C/T cg21664854 chr7:1097933 C7orf50;GPR146 0.78 8.91 0.44 3.56e-17 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC trans rs561341 0.941 rs17780080 chr17:30343146 G/A cg20587970 chr11:113659929 NA -1.43 -20.05 -0.74 5.67e-59 Hip circumference adjusted for BMI; CRC cis rs2880765 0.835 rs4360875 chr15:86040394 A/G cg17133734 chr15:86042851 AKAP13 0.44 7.03 0.36 1.21e-11 Coronary artery disease; CRC cis rs1799949 1.000 rs8176126 chr17:41259049 A/G cg19454999 chr17:41278357 BRCA1;NBR2 -0.56 -8.93 -0.44 3.11e-17 Menopause (age at onset); CRC cis rs9287719 0.649 rs10190673 chr2:10718618 T/C cg00105475 chr2:10696890 NA 0.45 7.06 0.36 9.97e-12 Prostate cancer; CRC trans rs1997103 0.911 rs11238361 chr7:55395981 A/G cg20935933 chr6:143382018 AIG1 0.53 6.78 0.35 5.42e-11 QRS interval (sulfonylurea treatment interaction); CRC cis rs6933660 0.646 rs9397410 chr6:151770503 C/T cg10883421 chr6:151773342 RMND1;C6orf211 0.8 14.38 0.62 1.06e-36 Menarche (age at onset); CRC cis rs758324 0.947 rs2133707 chr5:131181280 C/T cg06307176 chr5:131281290 NA 0.42 6.14 0.32 2.32e-9 Alzheimer's disease in APOE e4- carriers; CRC cis rs13118159 0.550 rs4974612 chr4:1364543 A/G cg16405210 chr4:1374714 KIAA1530 -0.91 -14.13 -0.61 8.96e-36 Longevity; CRC cis rs4481887 0.927 rs7524700 chr1:248472816 A/G cg00666640 chr1:248458726 OR2T12 0.48 8.14 0.41 7.98e-15 Common traits (Other); CRC cis rs7119 0.671 rs10152850 chr15:77904426 G/A cg10437265 chr15:77819839 NA -0.48 -8.43 -0.42 1.08e-15 Type 2 diabetes; CRC trans rs9956878 0.555 rs8085188 chr18:73544676 A/G cg11311579 chr10:102106754 SCD -0.38 -6.26 -0.33 1.19e-9 Obesity-related traits; CRC cis rs8060686 0.641 rs8060893 chr16:68191608 A/T cg08314208 chr16:67682810 RLTPR -0.58 -6.19 -0.32 1.76e-9 HDL cholesterol;Metabolic syndrome; CRC cis rs7737355 0.947 rs6882552 chr5:130841493 A/G cg06307176 chr5:131281290 NA 0.42 6.16 0.32 2.11e-9 Life satisfaction; CRC cis rs4253772 0.513 rs6008700 chr22:46722560 C/T cg03482458 chr22:46692211 CN5H6.4;GTSE1 0.57 7.85 0.4 6.06e-14 LDL cholesterol;Cholesterol, total; CRC cis rs2425143 0.908 rs74784474 chr20:34422464 C/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.52 -6.07 -0.32 3.49e-9 Blood protein levels; CRC cis rs3771570 1.000 rs56156035 chr2:242205955 T/A cg21155796 chr2:242212141 HDLBP 0.64 7.0 0.36 1.48e-11 Prostate cancer; CRC cis rs13108904 0.560 rs11247994 chr4:1343720 G/A cg24560729 chr4:1342394 KIAA1530 0.42 6.93 0.36 2.24e-11 Obesity-related traits; CRC cis rs568617 1.000 rs693824 chr11:65654783 A/G cg19792802 chr11:65647270 CTSW 0.5 7.55 0.38 4.23e-13 Crohn's disease; CRC cis rs736408 0.609 rs13061423 chr3:52790213 T/C cg18099408 chr3:52552593 STAB1 -0.44 -7.21 -0.37 3.76e-12 Bipolar disorder; CRC cis rs12188164 1.000 rs34453673 chr5:434722 G/C cg17553881 chr5:443987 EXOC3;C5orf55 -0.36 -7.49 -0.38 6.53e-13 Cystic fibrosis severity; CRC cis rs4555082 0.957 rs2816628 chr14:105736134 T/G cg06808227 chr14:105710500 BRF1 -0.62 -9.78 -0.47 5.4e-20 Mean platelet volume;Platelet distribution width; CRC cis rs35849525 0.814 rs35491931 chr3:49993462 T/A cg05623727 chr3:50126028 RBM5 0.53 6.94 0.36 2.09e-11 Intelligence (multi-trait analysis); CRC cis rs8077889 0.917 rs8081646 chr17:41893360 T/C cg16892393 chr17:41919603 NA 0.51 7.49 0.38 6.37e-13 Triglycerides; CRC cis rs2404602 0.716 rs17364076 chr15:76760891 C/T cg23625390 chr15:77176239 SCAPER 0.5 7.33 0.37 1.78e-12 Blood metabolite levels; CRC cis rs10883723 0.810 rs6584507 chr10:104254623 G/A cg04362960 chr10:104952993 NT5C2 -0.43 -6.1 -0.32 2.92e-9 Allergic disease (asthma, hay fever or eczema); CRC cis rs7824557 0.583 rs2263512 chr8:11233419 T/G cg20542592 chr8:11973495 FAM66D 0.36 6.22 0.32 1.48e-9 Retinal vascular caliber; CRC cis rs9916302 0.904 rs9892055 chr17:37510402 C/T cg15445000 chr17:37608096 MED1 -0.43 -9.5 -0.46 4.68e-19 Glomerular filtration rate (creatinine); CRC cis rs6951245 0.872 rs76161580 chr7:1100307 G/T cg22907277 chr7:1156413 C7orf50 0.73 7.68 0.39 1.78e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs2688608 0.592 rs11814282 chr10:75490217 T/C cg16540259 chr10:75572220 NDST2 0.38 5.91 0.31 8.72e-9 Inflammatory bowel disease; CRC cis rs13191362 1.000 rs35820211 chr6:163046252 C/T cg23758597 chr6:163146217 PARK2 -0.64 -6.28 -0.33 1.05e-9 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs8032158 0.702 rs2288345 chr15:56122461 T/C cg02198044 chr15:56286336 NEDD4 -0.36 -5.73 -0.3 2.33e-8 Keloid; CRC cis rs2836974 0.897 rs13047678 chr21:40708853 C/T cg11890956 chr21:40555474 PSMG1 0.94 14.2 0.62 5.07e-36 Cognitive function; CRC cis rs921968 0.608 rs495855 chr2:219357858 A/G cg02176678 chr2:219576539 TTLL4 0.49 8.05 0.41 1.58e-14 Mean corpuscular hemoglobin concentration; CRC cis rs4555082 0.874 rs2142190 chr14:105719306 G/A cg06808227 chr14:105710500 BRF1 -0.59 -8.31 -0.42 2.57e-15 Mean platelet volume;Platelet distribution width; CRC trans rs10242455 0.867 rs10282706 chr7:99217424 G/A cg09045935 chr12:6379348 NA 0.59 6.63 0.34 1.37e-10 Blood metabolite levels; CRC cis rs2239547 0.522 rs2581779 chr3:53056199 T/C cg11645453 chr3:52864694 ITIH4 -0.51 -8.62 -0.43 2.82e-16 Schizophrenia; CRC cis rs4889855 0.556 rs9897453 chr17:78634300 C/T cg16591659 chr17:78472290 NA -0.38 -5.84 -0.31 1.26e-8 Fractional excretion of uric acid; CRC cis rs6088590 1.000 rs6087626 chr20:33347328 C/T cg08999081 chr20:33150536 PIGU 0.51 8.68 0.43 1.9e-16 Coronary artery disease; CRC cis rs12497850 0.829 rs12636030 chr3:49182237 A/G cg07636037 chr3:49044803 WDR6 0.94 14.88 0.63 1.17e-38 Parkinson's disease; CRC cis rs992157 1.000 rs992157 chr2:219154781 A/G cg00012203 chr2:219082015 ARPC2 -0.53 -8.85 -0.44 5.49e-17 Colorectal cancer; CRC cis rs4713118 0.513 rs156739 chr6:28013410 C/A cg06470822 chr6:28175283 NA 0.8 11.88 0.55 2.47e-27 Parkinson's disease; CRC trans rs7395662 1.000 rs10839171 chr11:48923034 C/A cg21153622 chr11:89784906 NA 0.47 7.44 0.38 8.86e-13 HDL cholesterol; CRC cis rs6502050 0.835 rs35192339 chr17:80119106 G/A cg13198984 chr17:80129470 CCDC57 0.47 8.35 0.42 1.88e-15 Life satisfaction; CRC cis rs9322193 0.962 rs9322219 chr6:150103399 C/T cg13206674 chr6:150067644 NUP43 0.54 7.76 0.39 1.11e-13 Lung cancer; CRC cis rs514406 0.861 rs6588443 chr1:53250650 G/A cg25767906 chr1:53392781 SCP2 0.45 7.21 0.37 3.76e-12 Monocyte count; CRC cis rs6912958 0.514 rs7767449 chr6:87887985 A/C cg04972856 chr6:88032051 C6orf162;GJB7 -0.31 -5.84 -0.31 1.26e-8 Monocyte percentage of white cells; CRC cis rs7412746 0.586 rs2864882 chr1:150883037 C/T cg15448220 chr1:150897856 SETDB1 0.46 6.78 0.35 5.42e-11 Melanoma; CRC cis rs9322193 0.847 rs12234128 chr6:149948689 T/C cg00933542 chr6:150070202 PCMT1 0.29 6.07 0.32 3.54e-9 Lung cancer; CRC cis rs9488822 0.676 rs12202641 chr6:116314634 A/G cg26893134 chr6:116381904 FRK -0.27 -7.81 -0.4 7.64e-14 Cholesterol, total;LDL cholesterol; CRC cis rs7909074 0.832 rs10793564 chr10:45386352 C/A cg04218760 chr10:45406644 TMEM72 -0.34 -9.63 -0.47 1.72e-19 Mean corpuscular volume; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg03689283 chr3:196668656 NCBP2;LOC152217 0.48 6.78 0.35 5.42e-11 Response to antipsychotic treatment; CRC cis rs3736485 0.932 rs10519313 chr15:51915812 C/T cg08986416 chr15:51914746 DMXL2 -0.46 -6.53 -0.34 2.49e-10 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs4332037 0.906 rs6461009 chr7:1952139 T/C cg23422044 chr7:1970798 MAD1L1 0.56 7.09 0.36 8.01e-12 Bipolar disorder; CRC cis rs6735179 1.000 rs59771193 chr2:1778157 C/T cg19300414 chr2:1746591 PXDN 0.36 6.19 0.32 1.76e-9 Response to antipsychotic treatment; CRC cis rs8141529 0.748 rs5762874 chr22:29269658 C/G cg15103426 chr22:29168792 CCDC117 0.5 6.94 0.36 2.14e-11 Lymphocyte counts; CRC cis rs2635047 0.837 rs2571009 chr18:44650279 A/G cg19077165 chr18:44547161 KATNAL2 -0.54 -8.93 -0.44 3.17e-17 Educational attainment; CRC cis rs6460942 1.000 rs62448568 chr7:12407445 A/G cg20607287 chr7:12443886 VWDE -0.63 -6.64 -0.34 1.28e-10 Coronary artery disease; CRC cis rs2982552 0.773 rs62442016 chr6:152056053 C/A cg22157087 chr6:152012887 ESR1 0.37 5.66 0.3 3.31e-8 Bone properties (heel); CRC cis rs3858526 0.584 rs10734560 chr11:5864503 G/T cg05234568 chr11:5960015 NA -0.64 -9.17 -0.45 5.41e-18 DNA methylation (variation); CRC cis rs12802200 0.535 rs35541591 chr11:570538 C/A cg01842473 chr11:617407 IRF7;MUPCDH -0.49 -6.38 -0.33 6.11e-10 Systemic lupus erythematosus; CRC cis rs9309711 0.643 rs4535074 chr2:3481637 A/G cg10845886 chr2:3471009 TTC15 -0.39 -6.15 -0.32 2.21e-9 Neurofibrillary tangles; CRC trans rs12599106 0.839 rs3853177 chr16:34498532 A/G cg21548813 chr6:291882 DUSP22 -0.51 -7.1 -0.36 7.79e-12 Menopause (age at onset); CRC cis rs11191205 0.686 rs12255825 chr10:103422107 A/C cg15320455 chr10:103880129 LDB1 0.58 6.58 0.34 1.9e-10 Intelligence (multi-trait analysis); CRC cis rs2243480 1.000 rs313824 chr7:65581207 C/T cg12463550 chr7:65579703 CRCP 0.66 6.15 0.32 2.28e-9 Diabetic kidney disease; CRC cis rs11295209 1 rs11295209 chr4:120480233 TA/T cg09307838 chr4:120376055 NA -0.51 -7.75 -0.39 1.19e-13 Plateletcrit; CRC cis rs7615952 0.599 rs6803160 chr3:125709554 G/T cg06494592 chr3:125709126 NA -0.54 -6.57 -0.34 2e-10 Blood pressure (smoking interaction); CRC cis rs9399135 0.967 rs9389258 chr6:135361140 T/C cg22676075 chr6:135203613 NA 0.4 6.21 0.32 1.63e-9 Red blood cell count; CRC cis rs55788414 0.505 rs7190543 chr16:81189320 T/C cg06400318 chr16:81190750 PKD1L2 -0.47 -6.19 -0.32 1.76e-9 Left ventricular obstructive tract defect (maternal effect); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg08341821 chr5:81573780 RPS23 0.46 6.43 0.33 4.54e-10 Response to antipsychotic treatment; CRC cis rs6502050 0.835 rs8066284 chr17:80127825 C/T cg22110888 chr17:80059540 CCDC57 0.4 6.43 0.33 4.37e-10 Life satisfaction; CRC cis rs10504229 0.679 rs75402323 chr8:58136227 A/G cg05313129 chr8:58192883 C8orf71 -0.43 -6.11 -0.32 2.74e-9 Developmental language disorder (linguistic errors); CRC cis rs9611565 0.592 rs6519270 chr22:42078666 A/G cg03806693 chr22:41940476 POLR3H 0.68 9.3 0.46 2.03e-18 Vitiligo; CRC cis rs854555 0.651 rs854546 chr7:94923764 A/C cg19678392 chr7:94953810 PON1 0.44 5.99 0.31 5.35e-9 Response to TNF antagonist treatment; CRC cis rs6951245 1.000 rs884977 chr7:1066410 T/C cg22907277 chr7:1156413 C7orf50 0.48 5.73 0.3 2.31e-8 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs1003719 0.715 rs6517405 chr21:38560334 T/C cg10648535 chr21:38446584 PIGP;TTC3 -0.47 -6.62 -0.34 1.43e-10 Eye color traits; CRC cis rs4474465 0.646 rs10793335 chr11:78279005 C/G cg27205649 chr11:78285834 NARS2 0.53 6.88 0.35 2.99e-11 Alzheimer's disease (survival time); CRC cis rs4713118 0.662 rs9357060 chr6:28024486 C/G cg15845792 chr6:28175446 NA 0.95 13.85 0.61 1.07e-34 Parkinson's disease; CRC cis rs12760731 0.565 rs12027396 chr1:178149200 T/C cg00404053 chr1:178313656 RASAL2 1.02 10.73 0.51 3.15e-23 Obesity-related traits; CRC cis rs875971 0.862 rs801203 chr7:66023012 A/G cg12463550 chr7:65579703 CRCP -0.47 -6.46 -0.34 3.85e-10 Aortic root size; CRC cis rs2303759 0.709 rs3760667 chr19:49814832 C/T cg24324837 chr19:49891574 CCDC155 0.53 6.85 0.35 3.71e-11 Multiple sclerosis; CRC cis rs4604732 0.631 rs1106719 chr1:247624713 A/G cg02104434 chr1:247694406 LOC148824;OR2C3 -0.61 -9.06 -0.45 1.15e-17 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CRC cis rs7119 0.700 rs57471224 chr15:77888169 A/G cg10437265 chr15:77819839 NA -0.44 -7.82 -0.4 7.14e-14 Type 2 diabetes; CRC cis rs7412746 0.622 rs11552229 chr1:150783985 T/C cg18016565 chr1:150552671 MCL1 0.42 5.9 0.31 8.82e-9 Melanoma; CRC cis rs1577917 1.000 rs4707239 chr6:86610717 G/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.51 -6.86 -0.35 3.34e-11 Response to antipsychotic treatment; CRC cis rs7809950 1.000 rs2250414 chr7:107140987 T/G cg23024343 chr7:107201750 COG5 -0.6 -8.59 -0.43 3.64e-16 Coronary artery disease; CRC trans rs208520 0.690 rs1318604 chr6:66825278 A/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.07 -14.94 -0.64 7.14e-39 Exhaled nitric oxide output; CRC cis rs651907 0.535 rs13094911 chr3:101519021 T/C cg11279151 chr3:101281821 RG9MTD1 -0.53 -7.09 -0.36 8.3e-12 Colorectal cancer; CRC cis rs11122272 0.735 rs2572248 chr1:231514942 A/G cg06096015 chr1:231504339 EGLN1 0.4 5.95 0.31 6.7e-9 Hemoglobin concentration; CRC cis rs6570726 0.935 rs377130 chr6:145836632 C/T cg05347473 chr6:146136440 FBXO30 0.37 6.0 0.31 5.27e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs17270561 0.639 rs9356989 chr6:25781950 A/G cg17691542 chr6:26056736 HIST1H1C 0.73 8.86 0.44 5.23e-17 Iron status biomarkers; CRC cis rs972578 0.791 rs9607955 chr22:43216733 A/G cg01576275 chr22:43409880 NA -0.36 -5.63 -0.3 3.83e-8 Mean platelet volume; CRC cis rs2179367 0.959 rs9322178 chr6:149693267 G/C cg16235748 chr6:149772707 ZC3H12D -0.35 -5.76 -0.3 1.94e-8 Dupuytren's disease; CRC cis rs1348850 0.519 rs4144275 chr2:178523368 C/T cg02961200 chr2:178257176 LOC100130691;AGPS 0.52 7.26 0.37 2.75e-12 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs11864453 1.000 rs7201491 chr16:72034312 G/A cg01557791 chr16:72042693 DHODH -0.52 -7.34 -0.38 1.65e-12 Fibrinogen levels; CRC cis rs2046867 0.862 rs6788139 chr3:72835630 A/G cg25664220 chr3:72788482 NA 0.4 5.99 0.31 5.54e-9 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; CRC cis rs240764 0.578 rs9322216 chr6:101251720 A/C cg09795085 chr6:101329169 ASCC3 -0.41 -5.71 -0.3 2.58e-8 Neuroticism; CRC cis rs12594515 0.874 rs8032878 chr15:45998015 A/G cg19682013 chr15:45996608 NA 0.32 6.57 0.34 2e-10 Waist circumference;Weight; CRC trans rs11098499 0.826 rs4472123 chr4:120236630 T/A cg25214090 chr10:38739885 LOC399744 0.53 8.44 0.42 1.06e-15 Corneal astigmatism; CRC trans rs2727020 0.530 rs7113153 chr11:49457957 G/A cg03929089 chr4:120376271 NA -0.72 -9.41 -0.46 8.98e-19 Coronary artery disease; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg25593560 chr19:16187364 TPM4 0.38 6.04 0.32 4.2e-9 Liver disease severity in Alagille syndrome; CRC trans rs1455244 0.700 rs7229302 chr18:11508904 G/T cg08635118 chr7:6144369 USP42 0.38 5.99 0.31 5.42e-9 Schizophrenia; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg18013408 chr7:100487659 UFSP1;ACHE 0.37 6.24 0.33 1.36e-9 Liver disease severity in Alagille syndrome; CRC trans rs2727020 0.729 rs588458 chr11:49214048 C/A cg11707556 chr5:10655725 ANKRD33B 0.36 6.58 0.34 1.81e-10 Coronary artery disease; CRC cis rs6952808 1.000 rs6978048 chr7:1886872 T/G cg21782813 chr7:2030301 MAD1L1 0.45 7.44 0.38 9.07e-13 Bipolar disorder and schizophrenia; CRC cis rs11920354 0.642 rs9812878 chr3:47182787 T/C cg27129171 chr3:47204927 SETD2 0.63 9.44 0.46 7.27e-19 Granulocyte count;Sum neutrophil eosinophil counts; CRC trans rs877282 0.583 rs10904564 chr10:819459 C/G cg22713356 chr15:30763199 NA 0.87 9.74 0.47 7.43e-20 Uric acid levels; CRC trans rs7267979 0.933 rs2424708 chr20:25281398 C/T cg17903999 chr18:56338584 MALT1 -0.42 -6.77 -0.35 5.78e-11 Liver enzyme levels (alkaline phosphatase); CRC cis rs17270561 0.609 rs9348694 chr6:25753640 C/T cg17691542 chr6:26056736 HIST1H1C 0.7 9.09 0.45 9.29e-18 Iron status biomarkers; CRC cis rs1218582 0.688 rs58629129 chr1:154910930 T/C cg24250549 chr1:154909240 PMVK 0.58 8.59 0.43 3.57e-16 Prostate cancer; CRC cis rs6570726 0.791 rs7765687 chr6:145915100 A/C cg23711669 chr6:146136114 FBXO30 0.65 10.76 0.51 2.41e-23 Lobe attachment (rater-scored or self-reported); CRC cis rs7113874 0.655 rs67257872 chr11:8530218 A/G cg02811074 chr11:8615871 STK33 -0.34 -5.76 -0.3 1.94e-8 Body mass index in physically active individuals;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs11992162 1.000 rs7460395 chr8:11835375 C/T cg12568669 chr8:11666485 FDFT1 -0.32 -6.2 -0.32 1.74e-9 Monocyte count; CRC cis rs1322512 1.000 rs2758776 chr6:153006317 C/T cg03415253 chr6:152958462 SYNE1 0.4 6.04 0.32 4.18e-9 Tonometry; CRC cis rs853679 0.666 rs200956 chr6:27839746 A/G cg15845792 chr6:28175446 NA 0.7 8.22 0.41 4.63e-15 Depression; CRC trans rs9858542 1.000 rs11709525 chr3:49690496 C/T cg21582582 chr3:182698605 DCUN1D1 -0.58 -6.98 -0.36 1.65e-11 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs17152411 0.895 rs61872119 chr10:126583534 A/G cg07906193 chr10:126599966 NA 0.52 5.81 0.3 1.5e-8 Height; CRC cis rs9660180 0.967 rs2272908 chr1:1721479 A/G cg05132306 chr1:1846340 CALML6 0.42 6.49 0.34 3.22e-10 Body mass index; CRC cis rs9311474 0.659 rs7638808 chr3:52572056 C/T cg10802521 chr3:52805072 NEK4 0.55 8.76 0.43 1.03e-16 Electroencephalogram traits; CRC cis rs881375 1.000 rs10117059 chr9:123653477 G/C cg09419670 chr9:123605666 PSMD5;LOC253039 0.6 8.73 0.43 1.32e-16 Rheumatoid arthritis; CRC cis rs6761276 0.899 rs11678375 chr2:113835691 T/C cg09040174 chr2:113837401 NA 0.65 10.31 0.49 9.07e-22 Protein quantitative trait loci; CRC cis rs4862750 0.832 rs6836076 chr4:187899660 A/C cg07414643 chr4:187882934 NA 0.39 6.95 0.36 1.94e-11 Lobe attachment (rater-scored or self-reported); CRC cis rs7487075 0.790 rs11183527 chr12:46946363 A/G cg22049899 chr12:47219821 SLC38A4 0.29 5.81 0.31 1.44e-8 Itch intensity from mosquito bite; CRC cis rs780096 0.526 rs13472 chr2:27600239 G/A cg12648201 chr2:27665141 KRTCAP3 -0.31 -5.9 -0.31 9.05e-9 Total body bone mineral density; CRC cis rs2228479 0.867 rs35542367 chr16:89965825 G/C cg06558623 chr16:89946397 TCF25 1.02 10.71 0.51 3.68e-23 Skin colour saturation; CRC cis rs67478160 0.609 rs1547604 chr14:104270659 A/T cg08213375 chr14:104286397 PPP1R13B 0.57 11.69 0.54 1.26e-26 Schizophrenia; CRC cis rs1448094 0.621 rs10863091 chr12:86282240 T/C cg18827107 chr12:86230957 RASSF9 -0.45 -7.24 -0.37 3.29e-12 Major depressive disorder; CRC cis rs17095355 1.000 rs12267704 chr10:111722008 C/T cg00817464 chr10:111662876 XPNPEP1 -0.63 -8.52 -0.43 5.89e-16 Biliary atresia; CRC cis rs4819052 0.851 rs28442024 chr21:46674475 C/A cg02159808 chr21:46707872 POFUT2;LOC642852 0.52 6.74 0.35 7.22e-11 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC trans rs2303319 0.504 rs1006427 chr2:162592328 T/C cg14875682 chr5:52083620 ITGA1;PELO -0.73 -6.16 -0.32 2.11e-9 Cognitive function; CRC cis rs9399137 0.507 rs61738647 chr6:135282735 T/C cg24558204 chr6:135376177 HBS1L 0.6 8.74 0.43 1.17e-16 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; CRC cis rs67311347 0.822 rs11709089 chr3:40351484 C/T cg09455208 chr3:40491958 NA 0.36 6.93 0.36 2.23e-11 Renal cell carcinoma; CRC cis rs7927771 0.965 rs17788930 chr11:47752775 A/G cg18512352 chr11:47633146 NA -0.49 -9.58 -0.47 2.46e-19 Subjective well-being; CRC cis rs832540 0.656 rs2408597 chr5:56098632 G/A cg18230493 chr5:56204884 C5orf35 -0.41 -5.91 -0.31 8.45e-9 Coronary artery disease; CRC cis rs8067545 1.000 rs3909258 chr17:19945819 C/G cg13482628 chr17:19912719 NA 0.54 8.59 0.43 3.6e-16 Schizophrenia; CRC cis rs6499255 1.000 rs12596679 chr16:69822680 A/G cg00738113 chr16:70207722 CLEC18C 0.42 6.11 0.32 2.76e-9 IgE levels; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg25164226 chr22:47158357 TBC1D22A 0.46 6.51 0.34 2.88e-10 Response to antipsychotic treatment; CRC cis rs13064411 0.696 rs11921931 chr3:113015091 G/A cg18753928 chr3:113234510 CCDC52 -0.59 -7.78 -0.39 9.75e-14 Response to simvastatin treatment (PCSK9 protein level change); CRC cis rs7811142 0.943 rs66958101 chr7:100074020 G/A cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.72 9.7 0.47 1.01e-19 Platelet count; CRC cis rs7666738 0.830 rs1349757 chr4:99058763 C/G cg05340658 chr4:99064831 C4orf37 0.58 8.8 0.44 7.8e-17 Colonoscopy-negative controls vs population controls; CRC cis rs1577917 0.958 rs12207374 chr6:86656645 T/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.52 -6.8 -0.35 5.06e-11 Response to antipsychotic treatment; CRC cis rs3741404 0.791 rs2282491 chr11:63918373 T/C cg18225595 chr11:63971243 STIP1 0.63 10.5 0.5 1.94e-22 Platelet count; CRC cis rs208520 0.526 rs7771233 chr6:66819784 A/G cg07460842 chr6:66804631 NA -1.16 -23.51 -0.79 2.07e-72 Exhaled nitric oxide output; CRC cis rs10504229 0.639 rs55687236 chr8:58105856 C/T cg24829409 chr8:58192753 C8orf71 -0.67 -8.2 -0.41 5.6e-15 Developmental language disorder (linguistic errors); CRC cis rs2396545 0.638 rs1062099 chr11:567627 G/C cg16486109 chr11:613632 IRF7 0.68 10.62 0.51 7.53e-23 Systemic lupus erythematosus and Systemic sclerosis; CRC cis rs7949030 0.591 rs11231156 chr11:62366454 G/A cg22862634 chr11:62369728 EML3;MTA2 0.57 9.96 0.48 1.32e-20 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; CRC cis rs6088580 0.634 rs6088475 chr20:32964987 T/C cg24642439 chr20:33292090 TP53INP2 -0.38 -6.36 -0.33 6.76e-10 Glomerular filtration rate (creatinine); CRC cis rs4363385 0.574 rs4845505 chr1:152960943 T/A cg25856811 chr1:152973957 SPRR3 -0.25 -6.72 -0.35 7.92e-11 Inflammatory skin disease; CRC trans rs2898290 0.622 rs4840567 chr8:11347625 A/G cg06636001 chr8:8085503 FLJ10661 -0.48 -7.36 -0.38 1.45e-12 Systolic blood pressure; CRC cis rs6502050 0.799 rs4789674 chr17:80123200 G/A cg11859384 chr17:80120422 CCDC57 -0.36 -5.72 -0.3 2.43e-8 Life satisfaction; CRC cis rs9926296 0.632 rs1800286 chr16:89869761 T/C cg04287289 chr16:89883240 FANCA 0.59 9.07 0.45 1.14e-17 Vitiligo; CRC cis rs1443512 0.812 rs1975470 chr12:54336841 G/A cg17410650 chr12:54324560 NA -0.34 -6.14 -0.32 2.38e-9 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for BMI in non-smokers;Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction);Waist-hip ratio;Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour); CRC cis rs853679 0.546 rs200989 chr6:27816442 A/G cg26587870 chr6:27730563 NA -0.6 -5.88 -0.31 1.02e-8 Depression; CRC cis rs870825 0.616 rs28660669 chr4:185623312 C/T cg04058563 chr4:185651563 MLF1IP 0.72 9.38 0.46 1.12e-18 Blood protein levels; CRC cis rs780096 0.546 rs2293571 chr2:27729480 C/T cg21248554 chr2:27665150 KRTCAP3 -0.29 -6.63 -0.34 1.39e-10 Total body bone mineral density; CRC cis rs7071206 0.947 rs11002226 chr10:79399656 T/A cg07817648 chr10:79422355 NA -0.76 -9.76 -0.47 6.15e-20 Bone mineral density; CRC cis rs7617773 0.743 rs6804986 chr3:48363595 A/G cg11946769 chr3:48343235 NME6 0.66 8.96 0.44 2.55e-17 Coronary artery disease; CRC cis rs13108904 0.870 rs2279281 chr4:1245277 T/G cg02018176 chr4:1364513 KIAA1530 0.39 6.58 0.34 1.88e-10 Obesity-related traits; CRC trans rs7819412 0.715 rs35223712 chr8:11043926 C/T cg06636001 chr8:8085503 FLJ10661 -0.44 -6.53 -0.34 2.52e-10 Triglycerides; CRC trans rs75804782 0.641 rs72985387 chr2:239336589 G/A cg01134436 chr17:81009848 B3GNTL1 0.77 7.3 0.37 2.16e-12 Morning vs. evening chronotype;Chronotype; CRC cis rs736408 0.677 rs1042779 chr3:52821011 A/G cg18404041 chr3:52824283 ITIH1 -0.43 -9.14 -0.45 6.8e-18 Bipolar disorder; CRC cis rs10751667 0.643 rs7396951 chr11:927355 G/A cg23136738 chr11:925521 AP2A2 -0.41 -6.8 -0.35 4.92e-11 Alzheimer's disease (late onset); CRC cis rs4713118 0.513 rs149942 chr6:28001610 T/C cg10876282 chr6:28092338 ZSCAN16 0.46 6.3 0.33 9.74e-10 Parkinson's disease; CRC cis rs4654899 0.865 rs6658526 chr1:21391314 A/G cg02927042 chr1:21476669 EIF4G3 0.52 7.4 0.38 1.17e-12 Superior frontal gyrus grey matter volume; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg17133967 chr10:60144921 TFAM 0.41 6.18 0.32 1.85e-9 Intelligence (multi-trait analysis); CRC cis rs789859 0.869 rs1773225 chr3:194403578 A/G cg02072170 chr3:194406190 FAM43A 0.49 8.69 0.43 1.72e-16 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; CRC cis rs3733585 0.673 rs7376948 chr4:9954708 G/A cg00071950 chr4:10020882 SLC2A9 -0.56 -9.88 -0.48 2.45e-20 Cleft plate (environmental tobacco smoke interaction); CRC cis rs4731207 0.596 rs3903521 chr7:124668184 A/G cg23710748 chr7:124431027 NA -0.38 -6.06 -0.32 3.73e-9 Cutaneous malignant melanoma; CRC cis rs902774 0.818 rs73110464 chr12:53312612 C/T cg16329197 chr12:53359506 NA -0.56 -6.4 -0.33 5.45e-10 Prostate cancer; CRC cis rs8180040 0.967 rs807935 chr3:47321669 A/G cg02527881 chr3:46936655 PTH1R -0.4 -7.49 -0.38 6.52e-13 Colorectal cancer; CRC cis rs875971 0.862 rs17747530 chr7:65994729 G/C cg00343986 chr7:65444356 GUSB 0.44 6.15 0.32 2.21e-9 Aortic root size; CRC cis rs826838 1.000 rs11610522 chr12:38687575 C/T cg26384229 chr12:38710491 ALG10B 0.77 10.75 0.51 2.57e-23 Heart rate; CRC cis rs4711350 0.862 rs570749 chr6:33710229 C/T cg07979401 chr6:33739406 LEMD2 0.48 5.95 0.31 6.9e-9 Schizophrenia; CRC cis rs449789 0.857 rs543547 chr6:159702351 A/G cg14500486 chr6:159655392 FNDC1 -0.48 -7.4 -0.38 1.13e-12 Pulse pressure; CRC cis rs9901225 1 rs9901225 chr17:40755811 C/T cg11629889 chr17:40839022 CNTNAP1 0.47 8.01 0.4 2.04e-14 Colorectal or endometrial cancer; CRC trans rs11098499 0.863 rs3775844 chr4:120428033 G/A cg25214090 chr10:38739885 LOC399744 0.63 9.89 0.48 2.39e-20 Corneal astigmatism; CRC cis rs4974559 1.000 rs4974559 chr4:1380848 C/T cg02980000 chr4:1222292 CTBP1 -0.55 -7.25 -0.37 3.06e-12 Systolic blood pressure; CRC cis rs919433 0.783 rs805497 chr2:198222548 A/T cg10820045 chr2:198174542 NA 0.45 7.5 0.38 6.08e-13 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC cis rs10464366 0.517 rs13231075 chr7:39174806 G/T cg21665744 chr7:39171113 POU6F2 0.44 5.9 0.31 9.26e-9 IgG glycosylation; CRC cis rs56114371 0.777 rs200483 chr6:27774824 C/T cg23259851 chr6:27775964 HIST1H2AI;HIST1H2BL 0.71 5.99 0.31 5.54e-9 Breast cancer; CRC cis rs7552404 0.924 rs7544117 chr1:76158246 A/G cg22875332 chr1:76189707 ACADM 0.76 11.1 0.52 1.61e-24 Blood metabolite levels;Acylcarnitine levels; CRC cis rs7246865 0.859 rs1379281 chr19:17189786 A/G cg19418318 chr19:17219073 MYO9B -0.48 -7.84 -0.4 6.46e-14 Reticulocyte fraction of red cells; CRC cis rs3785574 0.962 rs9944483 chr17:61783553 G/T cg25654072 chr17:61904446 PSMC5;FTSJ3 -0.42 -5.88 -0.31 9.87e-9 Height; CRC cis rs10504229 0.906 rs73607869 chr8:58172665 G/T cg24829409 chr8:58192753 C8orf71 -0.68 -11.34 -0.53 2.27e-25 Developmental language disorder (linguistic errors); CRC cis rs7215564 0.908 rs1471788 chr17:78672153 A/G cg09596252 chr17:78655493 RPTOR 0.55 6.09 0.32 3.19e-9 Myopia (pathological); CRC cis rs67311347 1.000 rs4973993 chr3:40452960 T/C cg24209194 chr3:40518798 ZNF619 0.41 5.88 0.31 1.01e-8 Renal cell carcinoma; CRC cis rs1348850 0.914 rs6710575 chr2:178377311 C/T cg02961200 chr2:178257176 LOC100130691;AGPS 0.6 8.73 0.43 1.33e-16 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs7258465 1.000 rs10164319 chr19:18569833 G/A cg01065977 chr19:18549689 ISYNA1 -0.42 -6.47 -0.34 3.54e-10 Breast cancer; CRC cis rs2797160 0.967 rs80303782 chr6:126004193 C/T cg05901451 chr6:126070800 HEY2 -0.43 -6.57 -0.34 1.96e-10 Endometrial cancer; CRC cis rs9322193 0.847 rs62439808 chr6:149950826 C/T cg05861140 chr6:150128134 PCMT1 -0.36 -5.96 -0.31 6.32e-9 Lung cancer; CRC cis rs1448094 0.511 rs4492889 chr12:86146735 C/A cg25456477 chr12:86230367 RASSF9 -0.36 -6.07 -0.32 3.43e-9 Major depressive disorder; CRC cis rs11031096 0.782 rs10767845 chr11:4156922 C/T cg18678763 chr11:4115507 RRM1 -0.51 -8.43 -0.42 1.09e-15 Mean corpuscular volume;Mean corpuscular hemoglobin; CRC cis rs7647973 0.592 rs6774202 chr3:49687779 T/G cg03060546 chr3:49711283 APEH 0.66 8.13 0.41 8.84e-15 Menarche (age at onset); CRC cis rs4237845 0.611 rs7298370 chr12:58318897 C/T cg02175503 chr12:58329896 NA 0.83 13.72 0.6 3.43e-34 Intelligence (multi-trait analysis); CRC cis rs7781557 1.000 rs4610658 chr7:102445895 T/C cg18108683 chr7:102477205 FBXL13 -0.51 -6.64 -0.34 1.28e-10 Colorectal adenoma (advanced); CRC cis rs6500602 0.702 rs3761680 chr16:4524060 C/A cg08645402 chr16:4508243 NA 0.62 10.97 0.52 4.55e-24 Schizophrenia; CRC cis rs4862750 0.881 rs6813866 chr4:187872161 T/G cg27532560 chr4:187881888 NA -0.57 -10.37 -0.5 5.51e-22 Lobe attachment (rater-scored or self-reported); CRC cis rs2281845 0.507 rs1536127 chr1:201086894 C/A cg24849736 chr1:201084428 NA 0.49 6.71 0.35 8.35e-11 Permanent tooth development; CRC cis rs896854 0.625 rs13281709 chr8:95972819 T/A cg23172400 chr8:95962367 TP53INP1 -0.48 -8.18 -0.41 6.09e-15 Type 2 diabetes; CRC cis rs4731207 0.698 rs6466948 chr7:124444763 G/A cg23710748 chr7:124431027 NA 0.37 5.96 0.31 6.53e-9 Cutaneous malignant melanoma; CRC cis rs1670533 1.000 rs2045068 chr4:1052212 G/A cg27284194 chr4:1044797 NA 0.5 6.23 0.32 1.43e-9 Recombination rate (females); CRC cis rs875971 0.508 rs10253883 chr7:66061138 T/C cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.42 -6.27 -0.33 1.14e-9 Aortic root size; CRC cis rs853679 0.517 rs9393885 chr6:28050009 A/T cg15845792 chr6:28175446 NA 0.97 13.15 0.59 4.96e-32 Depression; CRC cis rs10512697 0.803 rs13172912 chr5:3578445 A/G cg19473799 chr5:3511975 NA -0.73 -5.8 -0.3 1.53e-8 Immune response to smallpox vaccine (IL-6); CRC cis rs8180040 0.726 rs2385867 chr3:47059323 C/T cg10298567 chr3:47292165 KIF9 -0.39 -6.2 -0.32 1.73e-9 Colorectal cancer; CRC cis rs9443645 0.869 rs4706747 chr6:79722639 A/G cg09184832 chr6:79620586 NA -0.51 -9.28 -0.46 2.3e-18 Intelligence (multi-trait analysis); CRC cis rs881375 0.967 rs1930778 chr9:123641369 A/C cg14255062 chr9:123606675 PSMD5;LOC253039 0.43 6.3 0.33 9.56e-10 Rheumatoid arthritis; CRC trans rs6550704 0.687 rs9865314 chr3:22634337 A/G cg20849121 chr1:12679951 NA -0.38 -6.12 -0.32 2.72e-9 Daytime sleep phenotypes; CRC cis rs754466 0.580 rs2579177 chr10:79529245 C/T cg17075019 chr10:79541650 NA -0.93 -17.32 -0.69 3.21e-48 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs4253772 0.591 rs6008595 chr22:46703860 A/T cg24881330 chr22:46731750 TRMU 0.6 6.87 0.35 3.31e-11 LDL cholesterol;Cholesterol, total; CRC cis rs79387448 0.701 rs11465596 chr2:102987093 C/A cg09003973 chr2:102972529 NA 0.98 10.07 0.49 5.61e-21 Gut microbiota (bacterial taxa); CRC trans rs60843830 0.596 rs17041320 chr2:112051 A/G cg11347411 chr7:150020925 ACTR3C;LRRC61 0.43 6.13 0.32 2.45e-9 Spherical equivalent (joint analysis main effects and education interaction); CRC cis rs7945718 1.000 rs7945718 chr11:12748819 A/G cg25843174 chr11:12811716 TEAD1 0.47 8.97 0.44 2.23e-17 Educational attainment (years of education); CRC cis rs1150668 0.699 rs2394049 chr6:28239681 A/G cg21251018 chr6:28226885 NKAPL 0.6 11.25 0.53 4.64e-25 Pubertal anthropometrics; CRC cis rs2811415 0.597 rs9812487 chr3:127807835 G/C cg13719885 chr3:127795394 NA -0.39 -5.9 -0.31 9.05e-9 Lung function (FEV1/FVC); CRC cis rs12745968 0.560 rs1325434 chr1:92961332 T/C cg17283838 chr1:93427260 FAM69A -0.45 -6.2 -0.32 1.73e-9 Bipolar disorder and schizophrenia; CRC cis rs9911578 1.000 rs12947785 chr17:57045160 A/C cg05425664 chr17:57184151 TRIM37 -0.5 -7.88 -0.4 4.85e-14 Intelligence (multi-trait analysis); CRC cis rs11764590 0.694 rs6977161 chr7:2099361 T/C cg14004847 chr7:1930337 MAD1L1 -0.42 -5.67 -0.3 3.15e-8 Neuroticism; CRC cis rs2882667 0.858 rs13177503 chr5:138432759 G/C cg04439458 chr5:138467593 SIL1 -0.35 -5.97 -0.31 6.02e-9 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs12586317 0.620 rs12437439 chr14:35585669 C/A cg05294307 chr14:35346193 BAZ1A -0.59 -6.3 -0.33 9.42e-10 Psoriasis; CRC cis rs11190604 1.000 rs10786597 chr10:102291287 C/T cg16342193 chr10:102329863 NA -0.36 -5.94 -0.31 7.21e-9 Palmitoleic acid (16:1n-7) levels; CRC cis rs6479527 0.840 rs1331219 chr9:96766248 A/G cg14459158 chr9:96720562 NA 0.38 6.99 0.36 1.51e-11 Esophageal adenocarcinoma; CRC cis rs7618915 0.501 rs767418 chr3:52767427 C/T cg11645453 chr3:52864694 ITIH4 0.36 6.48 0.34 3.31e-10 Bipolar disorder; CRC cis rs6951245 1.000 rs76388414 chr7:1100694 G/A cg21664854 chr7:1097933 C7orf50;GPR146 0.77 8.8 0.44 7.85e-17 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs7224685 0.501 rs781823 chr17:3966280 G/C cg10724054 chr17:3904396 NA -0.48 -8.12 -0.41 9.44e-15 Type 2 diabetes; CRC cis rs1448094 0.549 rs10863085 chr12:86236328 G/A cg18827107 chr12:86230957 RASSF9 -0.49 -8.07 -0.41 1.3e-14 Major depressive disorder; CRC cis rs1707322 0.963 rs11211229 chr1:46400517 A/C cg06784218 chr1:46089804 CCDC17 0.51 9.07 0.45 1.11e-17 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs2019137 0.560 rs10175462 chr2:113988492 G/A cg21610815 chr2:113994035 PAX8;LOC654433;LOC440839 0.56 8.42 0.42 1.14e-15 Lymphocyte counts; CRC cis rs12545109 0.917 rs10098993 chr8:57323116 T/C cg09654669 chr8:57350985 NA -0.44 -6.52 -0.34 2.72e-10 Obesity-related traits; CRC trans rs1005277 0.579 rs1780138 chr10:38501654 A/G cg17830980 chr10:43048298 ZNF37B -0.57 -9.66 -0.47 1.38e-19 Extrinsic epigenetic age acceleration; CRC cis rs477895 0.713 rs3802933 chr11:63988102 C/T cg19465662 chr11:63993652 NUDT22;TRPT1 0.74 9.14 0.45 6.61e-18 Mean platelet volume; CRC cis rs1375194 0.582 rs13388224 chr2:33802902 T/C cg04131969 chr2:33951647 MYADML -0.49 -7.11 -0.36 7.4e-12 Response to antidepressants in depression; CRC cis rs2404602 0.716 rs8025134 chr15:76781729 C/T cg03037974 chr15:76606532 NA 0.73 12.94 0.58 3.12e-31 Blood metabolite levels; CRC trans rs7615952 0.932 rs11922218 chr3:125631289 C/T cg00769240 chr8:12517080 NA -0.58 -6.84 -0.35 3.99e-11 Blood pressure (smoking interaction); CRC cis rs9322193 0.736 rs3828701 chr6:150112199 C/T cg05861140 chr6:150128134 PCMT1 -0.44 -7.18 -0.37 4.63e-12 Lung cancer; CRC trans rs1656966 1.000 rs1656966 chr3:186466252 C/T cg04571327 chr6:97345972 NDUFAF4 0.41 6.05 0.32 3.92e-9 Myopia (pathological); CRC cis rs2836950 0.840 rs12482317 chr21:40588241 A/G cg11644478 chr21:40555479 PSMG1 -0.42 -5.61 -0.3 4.19e-8 Menarche (age at onset); CRC cis rs6570726 0.764 rs76635693 chr6:145834070 T/C cg23711669 chr6:146136114 FBXO30 0.74 12.97 0.58 2.27e-31 Lobe attachment (rater-scored or self-reported); CRC cis rs10751667 0.714 rs7933889 chr11:972270 C/T cg23136738 chr11:925521 AP2A2 -0.43 -7.21 -0.37 3.89e-12 Alzheimer's disease (late onset); CRC cis rs4290604 0.748 rs62184776 chr2:238019306 T/G cg23555395 chr2:238036564 NA 0.57 5.98 0.31 5.96e-9 Asthma; CRC cis rs13191362 0.938 rs35211042 chr6:162998703 A/G cg06582575 chr6:163149167 PACRG;PARK2 0.74 10.67 0.51 5.17e-23 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs477895 0.653 rs7939784 chr11:63910153 C/T cg23719950 chr11:63933701 MACROD1 -0.65 -8.25 -0.41 3.82e-15 Mean platelet volume; CRC cis rs117623576 0.941 rs211409 chr10:32393213 T/C cg03047570 chr10:32398778 NA 0.82 9.11 0.45 8.14e-18 Anti-saccade response; CRC cis rs2179367 0.959 rs9373589 chr6:149707288 A/G cg07828024 chr6:149772892 ZC3H12D -0.37 -6.03 -0.32 4.29e-9 Dupuytren's disease; CRC trans rs877282 0.797 rs11253329 chr10:753200 A/T cg22713356 chr15:30763199 NA 1.19 13.88 0.61 8.17e-35 Uric acid levels; CRC cis rs921968 0.541 rs4674310 chr2:219318078 T/C cg02176678 chr2:219576539 TTLL4 -0.57 -9.12 -0.45 7.52e-18 Mean corpuscular hemoglobin concentration; CRC cis rs6585424 1.000 rs35483545 chr10:81939173 T/C cg11900509 chr10:81946545 ANXA11 -0.76 -9.33 -0.46 1.56e-18 Chronic obstructive pulmonary disease-related biomarkers; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg10457605 chr15:48623664 DUT 0.4 6.48 0.34 3.43e-10 Liver disease severity in Alagille syndrome; CRC cis rs17270561 0.609 rs6924782 chr6:25735816 C/G cg16482183 chr6:26056742 HIST1H1C 0.83 10.58 0.5 1.07e-22 Iron status biomarkers; CRC cis rs8072100 0.748 rs9912592 chr17:45556945 G/A cg08085267 chr17:45401833 C17orf57 -0.62 -9.82 -0.48 3.83e-20 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs3785574 0.962 rs2727331 chr17:61926990 G/T cg06601766 chr17:61851465 DDX42;CCDC47 0.57 8.01 0.4 2.07e-14 Height; CRC cis rs3751196 0.522 rs17034593 chr12:104190869 C/T cg02344784 chr12:104178138 NT5DC3 0.69 7.05 0.36 1.06e-11 Sense of smell; CRC cis rs7772486 0.875 rs10872582 chr6:146373061 G/A cg23711669 chr6:146136114 FBXO30 0.62 10.67 0.51 5.08e-23 Lobe attachment (rater-scored or self-reported); CRC cis rs796364 1.000 rs769950 chr2:200730028 A/G cg12253985 chr2:200820533 C2orf60;C2orf47 0.59 6.54 0.34 2.31e-10 Schizophrenia; CRC cis rs10256972 0.681 rs12702016 chr7:1129392 C/T cg18402987 chr7:1209562 NA 0.46 6.77 0.35 5.88e-11 Longevity;Endometriosis; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg19305511 chr19:9694932 ZNF121 0.46 6.5 0.34 2.93e-10 Response to antipsychotic treatment; CRC cis rs3760982 1.000 rs11665924 chr19:44286982 G/A cg12072164 chr19:44306565 LYPD5 0.41 6.41 0.33 5.16e-10 Breast cancer (estrogen-receptor negative);Breast cancer; CRC cis rs6089584 0.606 rs7270666 chr20:60577598 C/T cg23463467 chr20:60627584 TAF4 0.38 7.91 0.4 4.02e-14 Body mass index; CRC cis rs354033 1.000 rs3735320 chr7:149246680 A/T cg24335155 chr7:149193227 ZNF746 0.36 5.63 0.3 3.94e-8 Multiple sclerosis; CRC cis rs10504229 0.775 rs72650876 chr8:58161638 G/A cg11062466 chr8:58055876 NA 0.45 5.81 0.31 1.46e-8 Developmental language disorder (linguistic errors); CRC cis rs2692947 0.727 rs1657502 chr2:96795608 A/C cg23100626 chr2:96804247 ASTL 0.28 7.97 0.4 2.59e-14 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; CRC cis rs9611565 0.546 rs2092274 chr22:42123737 A/G cg06634786 chr22:41940651 POLR3H 0.6 7.02 0.36 1.24e-11 Vitiligo; CRC cis rs2652834 1.000 rs2729780 chr15:63404639 C/G cg05507819 chr15:63340323 TPM1 0.44 5.61 0.3 4.39e-8 HDL cholesterol; CRC cis rs8170 0.603 rs8109328 chr19:17417955 C/T cg04749549 chr19:17459798 NA -0.44 -7.54 -0.38 4.77e-13 Breast cancer (estrogen-receptor negative);Breast Cancer in BRCA1 mutation carriers;Ovarian cancer;Breast cancer;Epithelial ovarian cancer; CRC cis rs9908102 0.710 rs8079762 chr17:12910795 T/C cg26162695 chr17:12921313 ELAC2 0.43 5.85 0.31 1.17e-8 Schizophrenia; CRC cis rs10504229 0.906 rs61638902 chr8:58193511 A/C cg02725872 chr8:58115012 NA -0.38 -7.0 -0.36 1.46e-11 Developmental language disorder (linguistic errors); CRC cis rs7103648 0.553 rs12803857 chr11:47890172 G/A cg20307385 chr11:47447363 PSMC3 0.7 8.82 0.44 6.69e-17 Diastolic blood pressure;Systolic blood pressure; CRC cis rs4862750 0.872 rs9998172 chr4:187898773 T/C cg22105103 chr4:187893119 NA 0.64 11.62 0.54 2.13e-26 Lobe attachment (rater-scored or self-reported); CRC cis rs881375 0.967 rs7034492 chr9:123687211 G/A cg09419670 chr9:123605666 PSMD5;LOC253039 0.57 8.47 0.42 8.03e-16 Rheumatoid arthritis; CRC cis rs10791323 0.604 rs2723615 chr11:133704567 C/T cg03690763 chr11:133734501 NA -0.35 -5.87 -0.31 1.06e-8 Childhood ear infection; CRC cis rs6502050 0.761 rs7225637 chr17:80059758 A/G cg13198984 chr17:80129470 CCDC57 0.39 6.39 0.33 5.57e-10 Life satisfaction; CRC cis rs10791323 0.593 rs2156676 chr11:133715791 G/C cg15485101 chr11:133734466 NA 0.42 7.13 0.37 6.31e-12 Childhood ear infection; CRC trans rs1814175 0.645 rs7103554 chr11:50027612 G/A cg11707556 chr5:10655725 ANKRD33B -0.51 -9.99 -0.48 1.07e-20 Height; CRC cis rs3736485 0.873 rs11630336 chr15:51871643 T/C cg08986416 chr15:51914746 DMXL2 -0.48 -6.74 -0.35 7.14e-11 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs7712401 0.791 rs154507 chr5:122200907 C/G cg18764291 chr5:122110994 SNX2 -0.41 -6.55 -0.34 2.23e-10 Mean platelet volume; CRC cis rs501120 1.000 rs620356 chr10:44761073 A/C cg09554077 chr10:44749378 NA 0.78 11.96 0.55 1.33e-27 Coronary artery disease;Coronary heart disease; CRC cis rs344364 0.511 rs2982433 chr16:1954508 A/G cg03013636 chr16:1946785 NA 0.53 6.73 0.35 7.57e-11 Glomerular filtration rate in chronic kidney disease; CRC cis rs9303401 0.659 rs34382037 chr17:56643550 G/T cg02118635 chr17:56770003 RAD51C;TEX14 0.79 9.71 0.47 9.14e-20 Cognitive test performance; CRC cis rs9611565 0.840 rs2234059 chr22:41777913 T/C cg03806693 chr22:41940476 POLR3H -1.08 -13.76 -0.6 2.34e-34 Vitiligo; CRC cis rs3733585 0.699 rs6449174 chr4:9966422 C/T cg00071950 chr4:10020882 SLC2A9 -0.53 -9.26 -0.45 2.74e-18 Cleft plate (environmental tobacco smoke interaction); CRC trans rs8108034 1.000 rs39587 chr19:39806997 C/T cg21155778 chr12:95611301 FGD6;VEZT -0.54 -6.13 -0.32 2.54e-9 Lung adenocarcinoma; CRC cis rs3540 0.533 rs7495080 chr15:91056681 G/A cg22089800 chr15:90895588 ZNF774 -0.6 -10.17 -0.49 2.67e-21 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; CRC cis rs4363385 0.782 rs4845336 chr1:153003853 C/T cg25856811 chr1:152973957 SPRR3 -0.24 -6.72 -0.35 8.19e-11 Inflammatory skin disease; CRC cis rs11971779 0.680 rs7808740 chr7:139028955 G/T cg23387468 chr7:139079360 LUC7L2 0.41 7.29 0.37 2.34e-12 Diisocyanate-induced asthma; CRC cis rs9322193 0.962 rs1889473 chr6:150146621 C/G cg05861140 chr6:150128134 PCMT1 -0.42 -6.79 -0.35 5.4e-11 Lung cancer; CRC cis rs2952156 0.920 rs9303274 chr17:37836353 T/C cg11212589 chr17:38028394 ZPBP2 0.33 5.77 0.3 1.8e-8 Asthma; CRC cis rs904251 0.504 rs12202664 chr6:37481198 A/G cg01843034 chr6:37503916 NA -0.41 -7.44 -0.38 8.7e-13 Cognitive performance; CRC cis rs9549367 0.713 rs3024744 chr13:113821477 A/C cg00898013 chr13:113819073 PROZ -0.55 -8.08 -0.41 1.27e-14 Platelet distribution width; CRC cis rs4930103 0.602 rs170101 chr11:2008936 C/T cg06197492 chr11:2016605 H19 0.44 7.02 0.36 1.31e-11 DNA methylation (parent-of-origin);DNA methylation (variation); CRC cis rs2153535 0.623 rs6597338 chr6:8533508 A/C cg07606381 chr6:8435919 SLC35B3 0.68 11.04 0.52 2.51e-24 Motion sickness; CRC cis rs6582630 0.519 rs4294627 chr12:38293982 C/T cg26384229 chr12:38710491 ALG10B 0.69 9.77 0.47 5.73e-20 Drug-induced liver injury (flucloxacillin); CRC cis rs4713118 0.512 rs2622319 chr6:28120401 G/C cg25164649 chr6:28176230 NA 0.64 9.04 0.45 1.41e-17 Parkinson's disease; CRC cis rs208515 0.525 rs10944868 chr6:66687508 A/G cg07460842 chr6:66804631 NA 0.93 11.66 0.54 1.56e-26 Exhaled nitric oxide levels; CRC cis rs5769765 0.862 rs56377703 chr22:50306940 C/T cg04121214 chr22:50244548 NA 0.4 5.61 0.3 4.26e-8 Schizophrenia; CRC trans rs35110281 0.811 rs4819264 chr21:45017349 G/T cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.52 8.77 0.44 9.81e-17 Mean corpuscular volume; CRC cis rs4555082 0.834 rs2816623 chr14:105733295 G/A cg13114125 chr14:105738426 BRF1 -0.84 -12.19 -0.56 1.82e-28 Mean platelet volume;Platelet distribution width; CRC cis rs6557786 0.636 rs17052934 chr8:24840319 A/C cg04118306 chr8:24772350 NEFM -0.37 -6.67 -0.35 1.07e-10 Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 2 peripheral neuropathy); CRC cis rs68170813 0.559 rs10953532 chr7:106881808 C/T cg02696742 chr7:106810147 HBP1 -0.6 -6.48 -0.34 3.27e-10 Coronary artery disease; CRC cis rs2075671 0.903 rs62483570 chr7:100300649 C/T cg00334542 chr7:100209784 MOSPD3 -0.54 -6.8 -0.35 4.82e-11 Other erythrocyte phenotypes; CRC cis rs10504229 0.728 rs72650853 chr8:58151473 G/A cg02725872 chr8:58115012 NA -0.57 -9.07 -0.45 1.09e-17 Developmental language disorder (linguistic errors); CRC cis rs6586163 0.872 rs7914490 chr10:90747447 A/G cg03111039 chr10:90751583 FAS;ACTA2 -0.5 -7.08 -0.36 8.95e-12 Chronic lymphocytic leukemia; CRC cis rs1018836 0.608 rs2205150 chr8:91483232 G/A cg16814680 chr8:91681699 NA -0.58 -8.52 -0.43 5.79e-16 Ejection fraction in Tripanosoma cruzi seropositivity; CRC cis rs72945132 0.714 rs57320340 chr11:70160010 G/C cg00319359 chr11:70116639 PPFIA1 0.68 7.51 0.38 5.61e-13 Coronary artery disease; CRC cis rs929596 0.793 rs2741046 chr2:234580249 T/C cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.57 -7.95 -0.4 3.03e-14 Total bilirubin levels in HIV-1 infection; CRC cis rs4144743 0.641 rs67696888 chr17:45355116 A/G cg18085866 chr17:45331354 ITGB3 -0.51 -6.08 -0.32 3.29e-9 Body mass index; CRC cis rs56399783 0.901 rs73033408 chr7:2879755 C/T cg19731401 chr7:2775893 GNA12 0.62 6.1 0.32 2.95e-9 Childhood ear infection; CRC cis rs2576037 0.558 rs7244778 chr18:44541915 T/C cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.53 8.43 0.42 1.06e-15 Personality dimensions; CRC cis rs2580764 0.573 rs13387751 chr2:55227375 C/G cg09592903 chr2:55203963 RTN4 -0.73 -11.89 -0.55 2.25e-27 Mean platelet volume; CRC cis rs3087591 1.000 rs3087591 chr17:29630970 A/G cg24425628 chr17:29625626 OMG;NF1 -0.81 -13.7 -0.6 4.23e-34 Hip circumference; CRC trans rs783540 0.967 rs1259183 chr15:83279433 C/T cg18393722 chr15:85113863 UBE2QP1 -0.37 -6.2 -0.32 1.67e-9 Schizophrenia; CRC cis rs7666738 0.830 rs6831925 chr4:98947401 T/C cg17366294 chr4:99064904 C4orf37 0.43 7.34 0.38 1.71e-12 Colonoscopy-negative controls vs population controls; CRC cis rs4665809 1.000 rs4665308 chr2:26330514 C/A cg25036284 chr2:26402008 FAM59B -0.46 -5.97 -0.31 6e-9 Gut microbiome composition (summer); CRC cis rs367615 0.660 rs4632850 chr5:108832883 C/G cg17395555 chr5:108820864 NA 0.45 9.07 0.45 1.12e-17 Colorectal cancer (SNP x SNP interaction); CRC trans rs7267979 1.000 rs6115168 chr20:25372891 C/A cg17903999 chr18:56338584 MALT1 0.42 6.98 0.36 1.63e-11 Liver enzyme levels (alkaline phosphatase); CRC cis rs7119 0.623 rs12905318 chr15:77845873 T/C cg27398640 chr15:77910606 LINGO1 -0.41 -6.85 -0.35 3.59e-11 Type 2 diabetes; CRC cis rs4664304 1.000 rs6735923 chr2:160769588 A/G cg03641300 chr2:160917029 PLA2R1 -0.41 -5.75 -0.3 2.03e-8 Crohn's disease;Inflammatory bowel disease; CRC cis rs1799949 1.000 rs33920795 chr17:41329010 A/G cg19454999 chr17:41278357 BRCA1;NBR2 0.55 8.62 0.43 2.95e-16 Menopause (age at onset); CRC cis rs9905704 0.647 rs12940492 chr17:56954655 C/G cg12560992 chr17:57184187 TRIM37 0.61 9.24 0.45 3.23e-18 Testicular germ cell tumor; CRC cis rs1472360 0.505 rs1496526 chr8:86273899 G/A cg21346043 chr8:86351067 CA3 -0.39 -7.05 -0.36 1.09e-11 Mean corpuscular hemoglobin concentration; CRC cis rs10504229 1.000 rs77120900 chr8:58170368 C/T cg22535103 chr8:58192502 C8orf71 -0.82 -12.27 -0.56 9.63e-29 Developmental language disorder (linguistic errors); CRC cis rs910316 0.967 rs8013444 chr14:75661981 A/G cg03030879 chr14:75389066 RPS6KL1 0.42 6.47 0.34 3.57e-10 Height; CRC cis rs4332037 0.539 rs57148375 chr7:2025001 G/C cg25834613 chr7:1915315 MAD1L1 -0.47 -6.78 -0.35 5.54e-11 Bipolar disorder; CRC cis rs2243480 1.000 rs451396 chr7:65484074 T/A cg25985355 chr7:65971099 NA -0.5 -5.73 -0.3 2.25e-8 Diabetic kidney disease; CRC cis rs4862750 0.874 rs6553027 chr4:187875777 T/C cg11301795 chr4:187892539 NA -0.84 -18.41 -0.71 1.59e-52 Lobe attachment (rater-scored or self-reported); CRC cis rs3764400 0.567 rs12946143 chr17:46154943 C/T cg10706073 chr17:46328419 SKAP1 -0.62 -6.7 -0.35 8.86e-11 Body mass index; CRC cis rs13217239 0.646 rs6937880 chr6:27000236 C/T cg18867708 chr6:26865862 GUSBL1 0.37 5.67 0.3 3.09e-8 Schizophrenia; CRC cis rs12545109 0.959 rs12546307 chr8:57314790 T/A cg09654669 chr8:57350985 NA -0.45 -7.06 -0.36 9.69e-12 Obesity-related traits; CRC cis rs561341 0.941 rs8066156 chr17:30361629 A/G cg00745463 chr17:30367425 LRRC37B -0.68 -8.46 -0.42 9.01e-16 Hip circumference adjusted for BMI; CRC cis rs2948294 0.524 rs13270062 chr8:8112650 C/A cg06636001 chr8:8085503 FLJ10661 0.61 8.13 0.41 8.85e-15 Red cell distribution width; CRC cis rs72945132 0.882 rs12282678 chr11:70152457 G/A cg00319359 chr11:70116639 PPFIA1 0.68 7.51 0.38 5.61e-13 Coronary artery disease; CRC cis rs9392556 0.600 rs664299 chr6:4112241 T/G cg10424681 chr6:4079350 C6orf201;C6orf146 0.23 5.7 0.3 2.68e-8 Blood metabolite levels; CRC cis rs2645694 0.626 rs2703140 chr4:77830057 C/G cg10057126 chr4:77819792 ANKRD56 0.34 5.71 0.3 2.58e-8 Emphysema distribution in smoking; CRC cis rs1971762 0.527 rs6580952 chr12:53937452 C/T cg06632207 chr12:54070931 ATP5G2 0.44 7.45 0.38 8.2e-13 Height; CRC cis rs16924133 0.793 rs58883629 chr11:33128729 G/T cg05567920 chr11:33183001 CSTF3 -0.78 -5.92 -0.31 7.95e-9 Anger; CRC cis rs394563 0.601 rs391875 chr6:149795136 G/A cg07828024 chr6:149772892 ZC3H12D -0.39 -6.52 -0.34 2.67e-10 Dupuytren's disease; CRC cis rs10504229 1.000 rs17216711 chr8:58170856 T/C cg02290350 chr8:58132656 NA -0.42 -5.96 -0.31 6.62e-9 Developmental language disorder (linguistic errors); CRC cis rs67311347 0.577 rs11129870 chr3:40260406 G/A cg09455208 chr3:40491958 NA 0.32 6.58 0.34 1.89e-10 Renal cell carcinoma; CRC cis rs7659604 0.539 rs3217771 chr4:122739483 G/A cg23574427 chr4:122746245 BBS7;CCNA2 -0.3 -5.7 -0.3 2.61e-8 Type 2 diabetes; CRC cis rs523522 0.962 rs9040 chr12:120900274 C/T cg12219531 chr12:120966889 COQ5 0.7 9.3 0.46 2.08e-18 High light scatter reticulocyte count; CRC trans rs10504229 1.000 rs61212428 chr8:58173963 G/A cg04077850 chr5:125800366 GRAMD3 0.37 6.27 0.33 1.15e-9 Developmental language disorder (linguistic errors); CRC cis rs57221529 0.766 rs72703064 chr5:587825 T/C cg17948913 chr5:572064 NA 0.55 6.2 0.32 1.71e-9 Lung disease severity in cystic fibrosis; CRC cis rs853679 0.517 rs9380059 chr6:28132358 A/C cg12273811 chr6:28175739 NA 0.73 9.16 0.45 5.8e-18 Depression; CRC cis rs780096 0.565 rs813592 chr2:27721971 T/C cg22903471 chr2:27725779 GCKR -0.38 -6.27 -0.33 1.11e-9 Total body bone mineral density; CRC cis rs875971 0.522 rs7784623 chr7:65395034 T/G cg00343986 chr7:65444356 GUSB 0.56 8.54 0.43 4.98e-16 Aortic root size; CRC cis rs1190552 0.894 rs1190546 chr14:102904966 A/G cg18135206 chr14:102964638 TECPR2 -0.5 -6.15 -0.32 2.24e-9 Blood protein levels; CRC cis rs3820068 0.603 rs72647120 chr1:15956769 G/T cg13390004 chr1:15929781 NA 0.5 7.07 0.36 9.53e-12 Systolic blood pressure; CRC cis rs7666738 0.830 rs7657179 chr4:98948569 G/A cg05340658 chr4:99064831 C4orf37 0.61 9.54 0.47 3.45e-19 Colonoscopy-negative controls vs population controls; CRC cis rs951366 0.617 rs823080 chr1:205789282 G/A cg07157834 chr1:205819609 PM20D1 0.97 17.11 0.69 2.09e-47 Menarche (age at onset); CRC cis rs17270561 0.609 rs2275905 chr6:25768106 G/A cg17691542 chr6:26056736 HIST1H1C 0.64 8.14 0.41 8.02e-15 Iron status biomarkers; CRC cis rs9311474 0.508 rs11720159 chr3:52617802 T/G cg15147215 chr3:52552868 STAB1 -0.63 -10.9 -0.52 8.13e-24 Electroencephalogram traits; CRC cis rs231513 0.871 rs231522 chr17:41954602 A/G cg26893861 chr17:41843967 DUSP3 -0.72 -6.5 -0.34 3.05e-10 Cognitive function; CRC cis rs1448094 0.511 rs7976647 chr12:86158766 A/G cg02569458 chr12:86230093 RASSF9 0.47 7.83 0.4 6.55e-14 Major depressive disorder; CRC trans rs7544372 0.945 rs2066381 chr1:240995427 G/A cg24990238 chr5:169816960 KCNMB1;KCNIP1 -0.57 -6.29 -0.33 9.89e-10 Obesity-related traits; CRC cis rs501916 0.605 rs8031169 chr15:48080330 G/C cg16110827 chr15:48056943 SEMA6D -0.48 -7.24 -0.37 3.13e-12 Inflammatory bowel disease;Ulcerative colitis; CRC cis rs2386661 0.547 rs11259582 chr10:5646767 C/T cg26603656 chr10:5671107 NA 0.44 7.53 0.38 4.82e-13 Breast cancer; CRC cis rs7208859 0.562 rs11650923 chr17:29008167 G/A cg19761014 chr17:28927070 LRRC37B2 0.6 5.94 0.31 7.27e-9 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs2718058 0.692 rs2709117 chr7:37787807 A/G cg24998770 chr7:37888106 TXNDC3 0.35 5.87 0.31 1.08e-8 Alzheimer's disease (late onset); CRC trans rs3001167 0.609 rs6428253 chr1:194563821 G/A cg22004422 chr13:113740730 MCF2L -0.61 -6.19 -0.32 1.77e-9 Obesity-related traits; CRC cis rs4563143 0.663 rs10417671 chr19:29235335 T/C cg04546413 chr19:29218101 NA 0.39 6.08 0.32 3.31e-9 Methadone dose in opioid dependence; CRC cis rs172166 0.637 rs1233691 chr6:28153897 T/G cg15845792 chr6:28175446 NA 0.85 13.44 0.6 3.94e-33 Cardiac Troponin-T levels; CRC cis rs427941 0.667 rs34247954 chr7:101740993 C/T cg06246474 chr7:101738831 CUX1 0.46 7.24 0.37 3.2e-12 Plasma omega-3 polyunsaturated fatty acid level (eicosapentaenoic acid); CRC cis rs28386778 0.897 rs10221279 chr17:61806138 A/G cg25654072 chr17:61904446 PSMC5;FTSJ3 0.72 11.05 0.52 2.36e-24 Prudent dietary pattern; CRC cis rs7927771 0.832 rs7940536 chr11:47395240 G/A cg18512352 chr11:47633146 NA 0.34 6.55 0.34 2.28e-10 Subjective well-being; CRC cis rs8177253 0.763 rs8177224 chr3:133474003 C/G cg11941060 chr3:133502564 NA 0.57 9.51 0.46 4.04e-19 Iron status biomarkers; CRC cis rs2019137 0.936 rs4849169 chr2:113953657 A/C cg11763394 chr2:113992921 PAX8;LOC440839;LOC654433 -0.5 -7.2 -0.37 4.22e-12 Lymphocyte counts; CRC cis rs9549367 0.712 rs2316443 chr13:113864837 G/A cg18105134 chr13:113819100 PROZ -0.73 -10.93 -0.52 6.02e-24 Platelet distribution width; CRC cis rs754466 0.651 rs11813532 chr10:79637991 T/C cg17075019 chr10:79541650 NA -0.87 -15.04 -0.64 2.92e-39 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs11167764 1.000 rs10057309 chr5:141479870 T/C cg23435118 chr5:141488016 NDFIP1 -0.46 -7.24 -0.37 3.19e-12 Crohn's disease; CRC cis rs2522056 0.935 rs1981524 chr5:131756506 C/T cg24060327 chr5:131705240 SLC22A5 0.45 6.09 0.32 3.07e-9 Lymphocyte counts;Fibrinogen; CRC cis rs7131987 0.650 rs11050187 chr12:29472876 T/C cg09582351 chr12:29534625 ERGIC2 -0.33 -6.97 -0.36 1.7e-11 QT interval; CRC cis rs4363385 0.747 rs2075739 chr1:152975495 G/A cg25856811 chr1:152973957 SPRR3 -0.25 -6.76 -0.35 6.27e-11 Inflammatory skin disease; CRC cis rs3733585 0.673 rs4560411 chr4:9953361 A/G cg11266682 chr4:10021025 SLC2A9 -0.47 -9.62 -0.47 1.76e-19 Cleft plate (environmental tobacco smoke interaction); CRC trans rs853679 0.769 rs7752448 chr6:28301099 A/G cg01620082 chr3:125678407 NA -0.6 -6.22 -0.32 1.54e-9 Depression; CRC cis rs11792861 0.926 rs72607166 chr9:111821530 A/C cg05043794 chr9:111880884 C9orf5 -0.37 -6.71 -0.35 8.76e-11 Menarche (age at onset); CRC trans rs2890652 0.639 rs59504099 chr2:142966123 G/T cg00809969 chr7:27181067 HOXA5 -0.67 -6.09 -0.32 3.1e-9 Body mass index; CRC trans rs1997103 1.000 rs9649851 chr7:55398692 C/A cg20935933 chr6:143382018 AIG1 0.52 6.72 0.35 7.9e-11 QRS interval (sulfonylurea treatment interaction); CRC cis rs7737355 0.947 rs58895212 chr5:130797057 C/A cg06307176 chr5:131281290 NA -0.43 -6.35 -0.33 7.01e-10 Life satisfaction; CRC cis rs6121246 0.909 rs6089071 chr20:30378384 C/G cg13852791 chr20:30311386 BCL2L1 0.64 10.54 0.5 1.37e-22 Mean corpuscular hemoglobin; CRC cis rs736408 0.609 rs13082960 chr3:52785168 A/C cg11645453 chr3:52864694 ITIH4 0.35 6.1 0.32 3.04e-9 Bipolar disorder; CRC cis rs11971779 0.584 rs6942519 chr7:139070090 A/G cg07862535 chr7:139043722 LUC7L2 0.57 7.35 0.38 1.61e-12 Diisocyanate-induced asthma; CRC trans rs2727020 0.615 rs35423199 chr11:49514914 T/C cg11707556 chr5:10655725 ANKRD33B -0.4 -7.59 -0.39 3.31e-13 Coronary artery disease; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg01333225 chr19:16222203 RAB8A 0.44 6.35 0.33 7.23e-10 Intelligence (multi-trait analysis); CRC cis rs731174 0.765 rs599891 chr1:38176505 A/T cg06917450 chr1:38156652 C1orf109 -0.51 -7.07 -0.36 9.32e-12 Prostate cancer (SNP x SNP interaction); CRC cis rs3785574 0.962 rs2727332 chr17:61878584 T/A cg25654072 chr17:61904446 PSMC5;FTSJ3 0.44 6.09 0.32 3.13e-9 Height; CRC trans rs6550704 0.687 rs9865314 chr3:22634337 A/G cg04380228 chr2:47142555 MCFD2 -0.41 -6.03 -0.32 4.51e-9 Daytime sleep phenotypes; CRC cis rs12249377 0.519 rs7087400 chr10:92587180 A/G cg14313238 chr10:92632228 RPP30 0.47 6.57 0.34 2e-10 White matter microstructure (global fractional anisotropy); CRC cis rs7727544 0.735 rs274568 chr5:131713578 C/T cg07395648 chr5:131743802 NA 0.43 6.8 0.35 4.82e-11 Blood metabolite levels; CRC cis rs4665809 1.000 rs4665817 chr2:26305167 G/A cg26119090 chr2:26468346 HADHA;HADHB -0.67 -8.29 -0.42 2.95e-15 Gut microbiome composition (summer); CRC trans rs61931739 0.500 rs10772160 chr12:34456848 G/A cg26384229 chr12:38710491 ALG10B 0.62 9.03 0.45 1.52e-17 Morning vs. evening chronotype; CRC cis rs12467847 0.965 rs12467810 chr2:113691060 A/G cg12858261 chr2:113808755 IL1F8 0.4 5.85 0.31 1.22e-8 Response to amphetamines; CRC cis rs853679 0.769 rs7752448 chr6:28301099 A/G cg25164649 chr6:28176230 NA 0.63 5.9 0.31 9.05e-9 Depression; CRC cis rs7772486 0.754 rs12199362 chr6:146118225 A/G cg13319975 chr6:146136371 FBXO30 -0.47 -6.87 -0.35 3.19e-11 Lobe attachment (rater-scored or self-reported); CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg25467969 chr19:17337038 OCEL1 -0.41 -6.18 -0.32 1.87e-9 Myopia (pathological); CRC cis rs10493773 0.609 rs6689168 chr1:86174232 G/T cg23216685 chr1:86174607 ZNHIT6 -0.29 -6.88 -0.35 3.06e-11 Urate levels in overweight individuals; CRC cis rs2836974 0.931 rs12151994 chr21:40690397 A/C cg11644478 chr21:40555479 PSMG1 0.74 10.8 0.51 1.73e-23 Cognitive function; CRC cis rs7666738 0.800 rs13107147 chr4:99028753 C/T cg17366294 chr4:99064904 C4orf37 0.43 7.13 0.37 6.27e-12 Colonoscopy-negative controls vs population controls; CRC cis rs7584330 0.554 rs6760913 chr2:238400702 C/T cg08992911 chr2:238395768 MLPH 0.57 5.87 0.31 1.09e-8 Prostate cancer; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg15447669 chr2:234160727 ATG16L1 0.42 5.99 0.31 5.42e-9 Response to antipsychotic treatment; CRC cis rs4474465 1.000 rs2063729 chr11:78185969 C/T cg27205649 chr11:78285834 NARS2 -0.48 -5.97 -0.31 6.27e-9 Alzheimer's disease (survival time); CRC cis rs7552404 0.731 rs2029683 chr1:76341643 T/G cg10523679 chr1:76189770 ACADM -0.66 -8.11 -0.41 1e-14 Blood metabolite levels;Acylcarnitine levels; CRC cis rs7833986 0.534 rs72653928 chr8:56907735 A/G cg23139584 chr8:56987506 RPS20;SNORD54 0.78 11.37 0.53 1.73e-25 Height; CRC cis rs9875589 0.957 rs35485647 chr3:13937937 G/C cg19554555 chr3:13937349 NA 0.51 7.3 0.37 2.24e-12 Ovarian reserve; CRC cis rs8180040 0.900 rs10865946 chr3:47425060 T/G cg02527881 chr3:46936655 PTH1R -0.39 -7.46 -0.38 7.55e-13 Colorectal cancer; CRC cis rs4481887 0.741 rs1361413 chr1:248529521 C/G cg00666640 chr1:248458726 OR2T12 -0.42 -7.67 -0.39 1.97e-13 Common traits (Other); CRC cis rs9311676 0.594 rs55954186 chr3:58436476 G/A cg06643156 chr3:58380774 PXK 0.42 6.2 0.32 1.73e-9 Systemic lupus erythematosus; CRC cis rs10876993 0.890 rs4760165 chr12:58063801 C/T cg15848620 chr12:58087721 OS9 -0.62 -8.5 -0.42 6.6e-16 Celiac disease or Rheumatoid arthritis; CRC cis rs4332037 0.802 rs73048106 chr7:1929019 G/T cg23378565 chr7:2036160 MAD1L1 -0.47 -6.65 -0.34 1.25e-10 Bipolar disorder; CRC cis rs7223966 1.000 rs9912904 chr17:61763534 A/C cg23090583 chr17:61904693 PSMC5;FTSJ3 0.48 6.08 0.32 3.33e-9 Hip circumference adjusted for BMI;Body mass index; CRC cis rs12318506 0.623 rs12313311 chr12:75768327 A/T cg04728562 chr12:75699417 CAPS2 -0.74 -5.89 -0.31 9.7e-9 Coronary artery calcification; CRC cis rs4889855 0.505 rs8082303 chr17:78605012 A/G cg16591659 chr17:78472290 NA -0.43 -6.23 -0.33 1.39e-9 Fractional excretion of uric acid; CRC cis rs7591163 1.000 rs1721359 chr2:228751874 C/T cg22079747 chr2:228736145 WDR69 -0.45 -6.15 -0.32 2.29e-9 Blood pressure; CRC cis rs2404602 0.647 rs12910820 chr15:77022825 T/C cg23625390 chr15:77176239 SCAPER -0.83 -13.24 -0.59 2.27e-32 Blood metabolite levels; CRC cis rs9303280 0.806 rs62067034 chr17:38063738 C/T cg17344932 chr17:38183730 MED24;SNORD124 0.37 5.82 0.31 1.42e-8 Self-reported allergy; CRC cis rs72615157 0.634 rs2272343 chr7:99778285 A/C cg16268157 chr7:99778414 STAG3 -0.43 -5.72 -0.3 2.45e-8 Lung function (FEV1/FVC); CRC cis rs2153535 0.580 rs2327058 chr6:8447018 C/T cg07606381 chr6:8435919 SLC35B3 0.68 10.84 0.51 1.3e-23 Motion sickness; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg20918128 chr11:3663777 ART5 0.36 6.11 0.32 2.79e-9 Liver disease severity in Alagille syndrome; CRC cis rs737008 0.959 rs11865598 chr16:11403432 T/C cg00044050 chr16:11439710 C16orf75 0.44 5.84 0.31 1.28e-8 Obesity-related traits; CRC cis rs10979 1.000 rs9496678 chr6:143896664 C/A cg25407410 chr6:143891975 LOC285740 -0.84 -13.71 -0.6 3.9e-34 Hypospadias; CRC cis rs2836974 0.644 rs61300849 chr21:40680194 G/A cg22974920 chr21:40686053 BRWD1 -0.43 -6.01 -0.31 5.02e-9 Cognitive function; CRC cis rs1348850 0.914 rs2060929 chr2:178280031 T/C cg02961200 chr2:178257176 LOC100130691;AGPS 0.62 9.25 0.45 2.9e-18 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs2717559 0.683 rs2717611 chr8:143879927 C/T cg05569086 chr8:143859399 LYNX1 -0.48 -8.57 -0.43 4.02e-16 Urinary tract infection frequency; CRC cis rs2013441 0.866 rs8070401 chr17:20214492 C/T cg13482628 chr17:19912719 NA -0.39 -5.69 -0.3 2.86e-8 Obesity-related traits; CRC cis rs7772486 0.686 rs9376961 chr6:146048737 C/T cg23711669 chr6:146136114 FBXO30 0.64 10.59 0.5 9.73e-23 Lobe attachment (rater-scored or self-reported); CRC cis rs8030485 0.536 rs1915724 chr15:79441027 A/G cg17916960 chr15:79447300 NA 0.38 6.01 0.31 4.87e-9 Left ventricle wall thickness; CRC cis rs477895 1.000 rs7947143 chr11:64090422 G/A cg23719950 chr11:63933701 MACROD1 -0.58 -5.84 -0.31 1.25e-8 Mean platelet volume; CRC cis rs2204008 0.744 rs2222344 chr12:38406832 T/G cg26384229 chr12:38710491 ALG10B 0.69 9.74 0.47 7.27e-20 Bladder cancer; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg25824226 chr8:110551708 EBAG9 0.45 6.15 0.32 2.31e-9 Response to antipsychotic treatment; CRC cis rs9372498 0.536 rs724868 chr6:118795152 C/T cg22561889 chr6:118971681 C6orf204 0.48 6.03 0.32 4.35e-9 Diastolic blood pressure; CRC cis rs6681460 0.933 rs7554101 chr1:67156472 A/G cg02459107 chr1:67143332 SGIP1 -0.36 -6.19 -0.32 1.82e-9 Presence of antiphospholipid antibodies; CRC cis rs7208859 0.673 rs9898858 chr17:29156211 A/T cg13385521 chr17:29058706 SUZ12P 0.65 7.4 0.38 1.15e-12 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs6500395 1.000 rs36077931 chr16:48594221 A/G cg04672837 chr16:48644449 N4BP1 0.44 6.5 0.34 2.95e-10 Response to tocilizumab in rheumatoid arthritis; CRC cis rs1712517 0.904 rs6584547 chr10:105065409 C/T cg05636881 chr10:105038444 INA 0.46 8.0 0.4 2.19e-14 Migraine; CRC cis rs4604732 0.536 rs7528219 chr1:247628307 C/T cg12758973 chr1:247694275 LOC148824;OR2C3 0.38 5.75 0.3 2.03e-8 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CRC cis rs597539 0.689 rs596874 chr11:68630874 C/T cg11716795 chr11:68671300 MRPL21;IGHMBP2 -0.8 -14.32 -0.62 1.69e-36 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC trans rs2821260 0.902 rs12131816 chr1:72529866 A/G cg06365992 chr16:87350825 NA -0.5 -6.1 -0.32 3.04e-9 Intelligence (multi-trait analysis); CRC cis rs11031096 0.782 rs10835684 chr11:4168308 G/T cg18678763 chr11:4115507 RRM1 -0.42 -7.17 -0.37 4.97e-12 Mean corpuscular volume;Mean corpuscular hemoglobin; CRC cis rs7020830 0.867 rs1472169 chr9:37209396 C/T cg14294708 chr9:37120828 ZCCHC7 1.15 24.96 0.81 6.84e-78 Schizophrenia; CRC cis rs7618915 0.508 rs11717043 chr3:52656092 A/T cg15147215 chr3:52552868 STAB1 -0.62 -10.22 -0.49 1.76e-21 Bipolar disorder; CRC cis rs826838 1.000 rs55828987 chr12:39056421 A/C cg26384229 chr12:38710491 ALG10B 0.72 10.12 0.49 3.77e-21 Heart rate; CRC cis rs7617773 0.539 rs35460860 chr3:48392085 A/T cg11946769 chr3:48343235 NME6 0.62 8.34 0.42 2.13e-15 Coronary artery disease; CRC cis rs12477438 0.520 rs11695379 chr2:99742161 A/G cg26064155 chr2:99771622 LIPT1;TSGA10 0.89 16.26 0.67 4.86e-44 Chronic sinus infection; CRC cis rs10504229 0.683 rs16921823 chr8:58108612 G/C cg05313129 chr8:58192883 C8orf71 -0.43 -5.83 -0.31 1.36e-8 Developmental language disorder (linguistic errors); CRC cis rs7072216 0.763 rs10748729 chr10:100171371 G/C cg26618903 chr10:100175079 PYROXD2 -0.55 -8.99 -0.44 2.03e-17 Metabolite levels; CRC cis rs4423214 1.000 rs2276360 chr11:71169547 C/G cg05163923 chr11:71159392 DHCR7 0.66 9.37 0.46 1.19e-18 Vitamin D levels; CRC cis rs1218582 0.772 rs12095061 chr1:154912968 A/T cg06221963 chr1:154839813 KCNN3 -0.75 -14.78 -0.63 2.83e-38 Prostate cancer; CRC cis rs2440129 0.632 rs2292353 chr17:6903537 C/T cg09737314 chr17:6899359 ALOX12 0.57 10.3 0.49 9.72e-22 Tonsillectomy; CRC cis rs4713118 0.662 rs149969 chr6:27977737 A/G cg15845792 chr6:28175446 NA 0.83 12.37 0.56 4.15e-29 Parkinson's disease; CRC cis rs208515 0.525 rs12204706 chr6:66669930 A/G cg07460842 chr6:66804631 NA -0.89 -11.24 -0.53 5.16e-25 Exhaled nitric oxide levels; CRC cis rs478304 0.593 rs6591188 chr11:65467953 T/C cg05805236 chr11:65401703 PCNXL3 -0.4 -6.44 -0.33 4.26e-10 Acne (severe); CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg10699881 chr4:6271512 WFS1 0.42 5.98 0.31 5.94e-9 Anxiety disorder; CRC cis rs3785574 0.962 rs13030 chr17:61908556 C/T cg11494091 chr17:61959527 GH2 0.37 5.66 0.3 3.34e-8 Height; CRC cis rs9318086 0.712 rs1886970 chr13:24440498 T/C cg25267304 chr13:24462978 PCOTH;MIPEP 0.62 10.09 0.49 4.78e-21 Myopia (pathological); CRC cis rs28386778 0.897 rs2584617 chr17:61925298 C/T cg22520471 chr17:61851767 DDX42;CCDC47 0.75 11.76 0.54 6.89e-27 Prudent dietary pattern; CRC trans rs35110281 0.667 rs2250773 chr21:45087786 T/C cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.39 6.36 0.33 6.71e-10 Mean corpuscular volume; CRC cis rs826838 0.967 rs1719854 chr12:39127707 G/A cg26384229 chr12:38710491 ALG10B -0.64 -9.67 -0.47 1.21e-19 Heart rate; CRC cis rs10540 1.000 rs79440439 chr11:478147 A/C cg03934478 chr11:495069 RNH1 0.68 6.99 0.36 1.53e-11 Body mass index; CRC cis rs35110281 0.837 rs2838341 chr21:45076443 A/G cg04455712 chr21:45112962 RRP1B 0.4 7.86 0.4 5.53e-14 Mean corpuscular volume; CRC cis rs4243830 0.737 rs11122088 chr1:6603677 T/G cg15205204 chr1:6545172 PLEKHG5 0.41 5.77 0.3 1.85e-8 Body mass index; CRC cis rs6121246 0.954 rs7266148 chr20:30431070 G/T cg18721089 chr20:30220636 NA -0.35 -5.63 -0.3 3.91e-8 Mean corpuscular hemoglobin; CRC cis rs9341808 0.754 rs9294173 chr6:80991630 T/A cg08355045 chr6:80787529 NA 0.35 5.7 0.3 2.69e-8 Sitting height ratio; CRC cis rs9322193 0.923 rs9688452 chr6:149979900 G/A cg13206674 chr6:150067644 NUP43 0.67 9.97 0.48 1.25e-20 Lung cancer; CRC cis rs2084637 1.000 rs12223365 chr11:122416976 C/A cg21585512 chr11:122030076 LOC399959 -0.38 -6.78 -0.35 5.47e-11 Stroke; CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg15394763 chr10:77054788 NA 0.39 6.27 0.33 1.15e-9 Obesity-related traits; CRC cis rs8114671 0.562 rs8116657 chr20:33476474 C/G cg07148914 chr20:33460835 GGT7 0.43 6.9 0.36 2.6e-11 Height; CRC cis rs17401966 0.838 rs7553228 chr1:10350438 G/C cg19773385 chr1:10388646 KIF1B -0.67 -11.02 -0.52 3.09e-24 Hepatocellular carcinoma; CRC cis rs2046867 0.818 rs11929144 chr3:72868234 T/C cg25664220 chr3:72788482 NA -0.4 -6.31 -0.33 9.16e-10 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; CRC cis rs1580019 0.587 rs7806941 chr7:32553319 G/T cg14728415 chr7:32535168 LSM5;AVL9 0.45 6.38 0.33 6.1e-10 Cognitive ability; CRC cis rs2227564 0.620 rs11000785 chr10:75575963 T/C cg16540259 chr10:75572220 NDST2 0.51 7.94 0.4 3.27e-14 Crohn's disease;Inflammatory bowel disease; CRC cis rs2739330 0.828 rs2154593 chr22:24252085 A/G cg10150615 chr22:24372951 LOC391322 -0.64 -9.66 -0.47 1.39e-19 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs6788895 1.000 rs6795396 chr3:150510227 C/T cg09723797 chr3:150481914 SIAH2 0.86 6.3 0.33 9.6e-10 Breast cancer; CRC trans rs6430538 0.646 rs6734820 chr2:135536808 A/G cg15870184 chr7:99517151 TRIM4 0.38 6.09 0.32 3.16e-9 Parkinson's disease; CRC cis rs2295359 0.892 rs4655686 chr1:67638004 T/A cg03340356 chr1:67600835 NA 0.29 6.4 0.33 5.34e-10 Psoriasis; CRC cis rs3820068 0.581 rs3940061 chr1:15941276 C/T cg13390004 chr1:15929781 NA 0.5 7.08 0.36 8.64e-12 Systolic blood pressure; CRC cis rs2976388 0.609 rs2585150 chr8:143792669 C/T cg12516270 chr8:143859308 LYNX1 0.44 7.79 0.39 8.89e-14 Urinary tract infection frequency; CRC cis rs7666738 0.830 rs890470 chr4:98923435 A/C cg05340658 chr4:99064831 C4orf37 0.6 9.35 0.46 1.41e-18 Colonoscopy-negative controls vs population controls; CRC cis rs4953076 0.573 rs920519 chr2:44452344 T/C cg04920474 chr2:44395004 PPM1B 0.64 8.58 0.43 3.81e-16 Height; CRC trans rs9951602 0.573 rs8098953 chr18:76648734 A/G cg02800362 chr5:177631904 HNRNPAB 0.71 10.22 0.49 1.81e-21 Obesity-related traits; CRC cis rs13108904 0.870 rs13132584 chr4:1251504 G/T cg23123621 chr4:1343375 KIAA1530 0.32 5.64 0.3 3.65e-8 Obesity-related traits; CRC cis rs17376456 1.000 rs17376456 chr5:93557702 C/T cg09848695 chr5:92956644 FAM172A;MIR2277 -0.67 -5.69 -0.3 2.85e-8 Diabetic retinopathy; CRC cis rs2180341 0.597 rs3798859 chr6:127663116 C/T cg27446573 chr6:127587934 RNF146 0.62 9.17 0.45 5.4e-18 Breast cancer; CRC trans rs1572438 0.619 rs9502684 chr6:866737 G/A cg01563465 chr5:72512441 NA 0.31 6.14 0.32 2.4e-9 Aging; CRC cis rs1448094 0.512 rs61930861 chr12:86245023 G/T cg02569458 chr12:86230093 RASSF9 0.42 7.24 0.37 3.17e-12 Major depressive disorder; CRC cis rs939584 0.935 rs12714413 chr2:642253 T/C cg03610516 chr2:642275 NA 0.42 5.88 0.31 9.94e-9 Body mass index; CRC cis rs4563143 0.675 rs56293553 chr19:29270455 A/G cg12667521 chr19:29218732 NA 0.49 7.43 0.38 9.46e-13 Methadone dose in opioid dependence; CRC cis rs7647973 0.580 rs12629759 chr3:49237394 T/C cg20833759 chr3:49053208 WDR6;DALRD3 0.38 6.32 0.33 8.69e-10 Menarche (age at onset); CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg16868751 chr10:96162146 TBC1D12 -0.5 -6.48 -0.34 3.36e-10 Diisocyanate-induced asthma; CRC cis rs6540559 0.673 rs1073150 chr1:210017083 G/A cg22029157 chr1:209979665 IRF6 0.62 7.4 0.38 1.18e-12 Cleft lip with or without cleft palate; CRC cis rs2243480 1.000 rs6460261 chr7:65215580 T/C cg18252515 chr7:66147081 NA 1.16 13.27 0.59 1.71e-32 Diabetic kidney disease; CRC cis rs3008870 1.000 rs12137403 chr1:67437043 C/T cg08660285 chr1:67390436 MIER1;WDR78 -1.02 -14.67 -0.63 7.74e-38 Lymphocyte percentage of white cells; CRC cis rs7605827 0.897 rs1996516 chr2:15517246 G/A cg19274914 chr2:15703543 NA 0.39 5.94 0.31 7.35e-9 Educational attainment (years of education); CRC cis rs34779708 0.931 rs35136660 chr10:35385973 C/A cg03585969 chr10:35415529 CREM 0.67 8.87 0.44 4.78e-17 Inflammatory bowel disease;Crohn's disease; CRC cis rs2302190 0.882 rs11650710 chr17:56583547 C/T cg25885038 chr17:56607967 SEPT4 -0.52 -7.79 -0.39 9.08e-14 Vitamin D levels; CRC cis rs9372498 0.536 rs724868 chr6:118795152 C/T cg18833306 chr6:118973337 C6orf204 0.45 5.72 0.3 2.35e-8 Diastolic blood pressure; CRC cis rs7258465 1.000 rs2303697 chr19:18546678 T/C cg10790698 chr19:18539756 SSBP4 -0.47 -8.79 -0.44 8.33e-17 Breast cancer; CRC cis rs12410462 0.681 rs4486420 chr1:227572321 T/A cg23173402 chr1:227635558 NA 0.73 6.79 0.35 5.22e-11 Major depressive disorder; CRC cis rs72781680 1.000 rs72781665 chr2:24223086 G/A cg08917208 chr2:24149416 ATAD2B 0.9 8.9 0.44 3.79e-17 Lymphocyte counts; CRC cis rs34172651 0.606 rs7194189 chr16:24703484 G/T cg02428538 chr16:24856791 SLC5A11 0.56 6.76 0.35 6.38e-11 Intelligence (multi-trait analysis); CRC cis rs7493 1.000 rs2299265 chr7:95048870 C/G cg21856205 chr7:94953877 PON1 -0.51 -6.51 -0.34 2.73e-10 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs56235845 0.694 rs4532376 chr5:176774403 G/A cg17509989 chr5:176798049 RGS14 0.62 10.27 0.49 1.16e-21 Hemoglobin concentration;Hematocrit; CRC trans rs2303319 0.504 rs62188728 chr2:162335701 T/C cg11875773 chr22:50468633 TTLL8 -0.68 -6.05 -0.32 3.92e-9 Cognitive function; CRC trans rs3008706 0.584 rs7856877 chr9:15852445 G/C cg15918921 chr2:74212782 NA -0.53 -6.1 -0.32 2.9e-9 Bilirubin levels; CRC cis rs1005277 0.579 rs2505194 chr10:38393881 C/T cg00409905 chr10:38381863 ZNF37A -0.68 -11.24 -0.53 4.82e-25 Extrinsic epigenetic age acceleration; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg16435601 chr17:65822392 BPTF 0.41 6.35 0.33 7.25e-10 Liver disease severity in Alagille syndrome; CRC cis rs10504229 1.000 rs77857677 chr8:58170131 G/A cg05313129 chr8:58192883 C8orf71 -0.47 -6.99 -0.36 1.49e-11 Developmental language disorder (linguistic errors); CRC cis rs7527798 0.592 rs12022909 chr1:207859743 T/C cg21110645 chr1:207815933 NA -0.38 -6.05 -0.32 4.04e-9 Erythrocyte sedimentation rate; CRC cis rs28386778 0.897 rs8081454 chr17:61842646 A/G cg22520471 chr17:61851767 DDX42;CCDC47 0.74 11.57 0.54 3.22e-26 Prudent dietary pattern; CRC cis rs1801251 1.000 rs1446311 chr2:233705071 G/A cg25237894 chr2:233734115 C2orf82 -0.54 -8.79 -0.44 8.63e-17 Coronary artery disease; CRC cis rs763121 0.853 rs6519124 chr22:39045099 T/C cg06544989 chr22:39130855 UNC84B 0.46 7.37 0.38 1.4e-12 Menopause (age at onset); CRC cis rs11098499 0.542 rs10440343 chr4:120309787 G/C cg24375607 chr4:120327624 NA 0.51 7.86 0.4 5.5e-14 Corneal astigmatism; CRC cis rs9768139 0.611 rs12698211 chr7:158119623 G/A cg06219351 chr7:158114137 PTPRN2 -0.55 -8.34 -0.42 2.11e-15 Calcium levels; CRC cis rs748404 0.660 rs2439845 chr15:43722610 C/G cg02155558 chr15:43621948 ADAL;LCMT2 0.53 7.88 0.4 4.67e-14 Lung cancer; CRC cis rs950169 0.959 rs12902070 chr15:84793558 T/C cg03959625 chr15:84868606 LOC388152 0.41 6.04 0.32 4.05e-9 Schizophrenia; CRC cis rs6952808 0.929 rs2280550 chr7:1976556 G/A cg21782813 chr7:2030301 MAD1L1 0.48 7.82 0.4 7.26e-14 Bipolar disorder and schizophrenia; CRC cis rs1005277 0.522 rs1208767 chr10:38042295 G/T cg25427524 chr10:38739819 LOC399744 -0.73 -12.73 -0.57 1.94e-30 Extrinsic epigenetic age acceleration; CRC cis rs4555082 0.834 rs2816653 chr14:105713973 A/G cg06808227 chr14:105710500 BRF1 -0.65 -9.78 -0.47 5.43e-20 Mean platelet volume;Platelet distribution width; CRC cis rs1267303 0.562 rs2476162 chr1:47007324 G/A cg25110126 chr1:46999211 NA 0.46 7.02 0.36 1.25e-11 Monobrow; CRC cis rs10883723 0.810 rs10786671 chr10:104271303 G/A cg11453585 chr10:104263688 ACTR1A;SUFU 0.91 17.35 0.69 2.37e-48 Allergic disease (asthma, hay fever or eczema); CRC cis rs9914988 0.943 rs2242345 chr17:27185827 C/T cg12682573 chr17:27188876 MIR451;MIR144 -0.57 -7.92 -0.4 3.79e-14 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs6500602 0.673 rs4786513 chr16:4576423 T/C cg13763550 chr16:4524223 NMRAL1;HMOX2 0.43 5.69 0.3 2.8e-8 Schizophrenia; CRC cis rs7082209 1.000 rs7082209 chr10:44814336 C/T cg09554077 chr10:44749378 NA -0.42 -5.66 -0.3 3.38e-8 Resistance to Mycobacterium tuberculosis in HIV-positive individuals measured by a negative tuberculin skin test (continuous); CRC cis rs10992471 0.756 rs11792342 chr9:95143668 G/A cg14631576 chr9:95140430 CENPP -0.4 -7.44 -0.38 8.78e-13 Visceral adipose tissue/subcutaneous adipose tissue ratio; CRC cis rs7072216 0.763 rs1061437 chr10:100176154 C/T cg26618903 chr10:100175079 PYROXD2 -0.53 -8.81 -0.44 7.21e-17 Metabolite levels; CRC cis rs11122272 0.735 rs2295420 chr1:231485640 C/T cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.57 -8.77 -0.44 9.76e-17 Hemoglobin concentration; CRC cis rs6952808 0.792 rs2056480 chr7:1954301 A/G cg20295408 chr7:1910781 MAD1L1 0.43 5.99 0.31 5.36e-9 Bipolar disorder and schizophrenia; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg14640386 chr17:5185735 RABEP1 -0.39 -5.98 -0.31 5.91e-9 Myopia (pathological); CRC cis rs1532331 0.966 rs6451674 chr5:43110754 C/T cg09164108 chr5:43007320 NA 0.38 5.73 0.3 2.23e-8 Menarche (age at onset); CRC cis rs6743376 0.532 rs2515395 chr2:113818702 G/C cg09040174 chr2:113837401 NA 0.44 6.44 0.33 4.3e-10 Inflammatory biomarkers; CRC cis rs6912958 0.559 rs242267 chr6:88061837 A/G cg12350822 chr6:88032061 C6orf162;GJB7 -0.45 -8.82 -0.44 7.07e-17 Monocyte percentage of white cells; CRC cis rs7932354 0.528 rs11039107 chr11:47157866 G/A cg03339077 chr11:47165057 C11orf49 -0.46 -6.36 -0.33 6.9e-10 Bone mineral density (hip);Bone mineral density; CRC cis rs501916 1.000 rs648627 chr15:48055738 C/T cg16110827 chr15:48056943 SEMA6D -0.36 -6.07 -0.32 3.49e-9 Inflammatory bowel disease;Ulcerative colitis; CRC cis rs8031584 0.678 rs8028173 chr15:31155749 A/G cg14829155 chr15:31115871 NA -0.66 -10.21 -0.49 1.9e-21 Huntington's disease progression; CRC cis rs1707322 1.000 rs6687301 chr1:46382852 T/C cg06784218 chr1:46089804 CCDC17 0.52 9.12 0.45 7.88e-18 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs12188164 0.543 rs2434694 chr5:462734 C/T cg14122633 chr5:456516 EXOC3 -0.4 -7.16 -0.37 5.37e-12 Cystic fibrosis severity; CRC cis rs12148488 0.966 rs1867148 chr15:75339985 T/C cg17294928 chr15:75287854 SCAMP5 -0.41 -6.04 -0.32 4.14e-9 Caffeine consumption; CRC cis rs490234 0.934 rs13293237 chr9:128430966 T/C cg14078157 chr9:128172775 NA -0.37 -6.08 -0.32 3.26e-9 Mean arterial pressure; CRC cis rs9462027 0.628 rs6929567 chr6:34692735 T/C cg07306190 chr6:34760872 UHRF1BP1 0.34 6.07 0.32 3.49e-9 Systemic lupus erythematosus; CRC cis rs7937682 0.883 rs517982 chr11:111462687 T/C cg19812747 chr11:111475976 SIK2 -0.56 -9.46 -0.46 5.87e-19 Primary sclerosing cholangitis; CRC cis rs12760731 0.623 rs71628283 chr1:178458450 G/A cg00404053 chr1:178313656 RASAL2 0.95 9.31 0.46 1.93e-18 Obesity-related traits; CRC trans rs8002861 0.846 rs12867732 chr13:44483084 C/A cg17145862 chr1:211918768 LPGAT1 -0.69 -12.38 -0.56 3.63e-29 Leprosy; CRC cis rs1057239 0.739 rs1014554 chr1:175133626 A/G cg00321850 chr1:175162397 KIAA0040 0.43 7.36 0.38 1.47e-12 Diastolic blood pressure; CRC cis rs853679 1.000 rs1778511 chr6:28229411 G/A cg03623178 chr6:28175578 NA -0.7 -7.3 -0.37 2.15e-12 Depression; CRC cis rs79349575 0.783 rs4793991 chr17:47001801 A/G cg00947319 chr17:47005597 UBE2Z -0.34 -5.88 -0.31 9.88e-9 Type 2 diabetes; CRC cis rs67311347 0.955 rs11719205 chr3:40417258 G/A cg09455208 chr3:40491958 NA 0.43 8.76 0.43 1.05e-16 Renal cell carcinoma; CRC cis rs6831352 0.879 rs29001215 chr4:100051722 T/C cg12011299 chr4:100065546 ADH4 -0.49 -9.21 -0.45 4.04e-18 Alcohol dependence; CRC cis rs7618915 0.571 rs6805539 chr3:52609710 T/A cg08222913 chr3:52553049 STAB1 -0.34 -6.3 -0.33 9.31e-10 Bipolar disorder; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg15008879 chr10:22292810 DNAJC1 0.47 6.19 0.32 1.78e-9 Thyroid stimulating hormone; CRC cis rs17376456 0.877 rs9314093 chr5:93333347 G/A cg25358565 chr5:93447407 FAM172A 1.07 10.6 0.5 8.87e-23 Diabetic retinopathy; CRC cis rs7591163 1.000 rs1039665 chr2:228717392 A/G cg08034379 chr2:228736324 WDR69 -0.54 -7.27 -0.37 2.63e-12 Blood pressure; CRC trans rs6940638 0.956 rs3922717 chr6:27030924 A/G cg06606381 chr12:133084897 FBRSL1 -0.6 -6.52 -0.34 2.71e-10 Intelligence (multi-trait analysis); CRC cis rs9911578 0.967 rs11079354 chr17:56594460 G/A cg05425664 chr17:57184151 TRIM37 0.51 8.14 0.41 8.43e-15 Intelligence (multi-trait analysis); CRC cis rs1552244 0.882 rs13077641 chr3:10022935 G/A cg10729496 chr3:10149963 C3orf24 0.48 6.25 0.33 1.25e-9 Alzheimer's disease; CRC cis rs11971779 0.584 rs7786469 chr7:139094621 G/A cg23387468 chr7:139079360 LUC7L2 0.41 7.04 0.36 1.14e-11 Diisocyanate-induced asthma; CRC cis rs875971 0.545 rs11767262 chr7:65767224 T/A cg03233332 chr7:66118400 NA -0.44 -6.22 -0.32 1.49e-9 Aortic root size; CRC cis rs2019137 0.539 rs6755040 chr2:113981137 T/C cg12889195 chr2:113992843 PAX8;LOC440839;LOC654433 0.66 10.21 0.49 1.95e-21 Lymphocyte counts; CRC cis rs9649213 0.593 rs1076272 chr7:98031005 C/G cg08684580 chr7:98029266 BAIAP2L1 -0.32 -5.78 -0.3 1.78e-8 Prostate cancer (SNP x SNP interaction); CRC cis rs597539 0.617 rs686348 chr11:68636996 A/G cg21963583 chr11:68658836 MRPL21 0.59 10.65 0.51 6e-23 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC trans rs7539118 0.623 rs12127810 chr1:189526779 C/T cg17255063 chr4:41751830 PHOX2B -0.57 -6.25 -0.33 1.24e-9 Daytime sleep phenotypes; CRC cis rs2677744 0.626 rs12905855 chr15:91498429 G/C cg23684204 chr15:91497937 RCCD1 0.45 6.8 0.35 4.84e-11 Attention deficit hyperactivity disorder; CRC cis rs1448094 0.845 rs11117129 chr12:86349390 A/G cg25456477 chr12:86230367 RASSF9 0.33 5.62 0.3 4.16e-8 Major depressive disorder; CRC trans rs7395662 0.963 rs9667588 chr11:48730337 C/T cg21153622 chr11:89784906 NA 0.46 7.41 0.38 1.06e-12 HDL cholesterol; CRC trans rs1490453 0.629 rs6829009 chr4:149247221 G/C cg09978996 chr10:70321668 TET1 -0.41 -6.03 -0.32 4.29e-9 Biochemical measures; CRC cis rs1950626 0.623 rs61991083 chr14:101436435 T/C cg02351406 chr14:101447389 SNORD114-20;SNORD114-21 0.75 12.07 0.55 5.21e-28 Pelvic organ prolapse (moderate/severe); CRC cis rs644148 0.730 rs2571044 chr19:44985573 G/A cg15540054 chr19:45004280 ZNF180 -0.54 -6.82 -0.35 4.5e-11 Personality dimensions; CRC cis rs17253792 0.822 rs8013714 chr14:56172286 T/C cg01858014 chr14:56050164 KTN1 -0.72 -6.94 -0.36 2.05e-11 Putamen volume; CRC cis rs929354 0.742 rs3808317 chr7:156944460 A/G cg17757837 chr7:157058334 UBE3C 0.74 12.39 0.56 3.31e-29 Body mass index; CRC cis rs7074356 0.522 rs1591958 chr10:82062661 G/A cg27171509 chr10:82033454 MAT1A -0.41 -7.88 -0.4 4.76e-14 Borderline personality disorder; CRC cis rs7772486 0.764 rs9399569 chr6:146242942 C/T cg13319975 chr6:146136371 FBXO30 0.39 5.84 0.31 1.24e-8 Lobe attachment (rater-scored or self-reported); CRC cis rs2075371 0.829 rs10954442 chr7:134007587 A/G cg11752832 chr7:134001865 SLC35B4 -0.44 -6.7 -0.35 8.85e-11 Mean platelet volume; CRC cis rs853679 0.550 rs9295762 chr6:28155418 C/T cg12273811 chr6:28175739 NA -0.74 -10.32 -0.49 7.94e-22 Depression; CRC cis rs9292777 0.692 rs55904678 chr5:40397400 T/C cg09067459 chr5:40385259 NA -0.55 -9.01 -0.44 1.72e-17 Crohn's disease;Multiple sclerosis; CRC cis rs7777484 0.534 rs2533890 chr7:2828743 C/T cg09658497 chr7:2847517 GNA12 -0.38 -6.32 -0.33 8.47e-10 Height; CRC cis rs4713118 0.955 rs9468203 chr6:27688667 A/G cg02683197 chr6:28174875 NA 0.54 6.94 0.36 2.11e-11 Parkinson's disease; CRC cis rs4713118 0.869 rs9283883 chr6:27715470 T/A cg20933634 chr6:27740509 NA 0.58 8.46 0.42 8.89e-16 Parkinson's disease; CRC cis rs13256369 1.000 rs12547721 chr8:8570671 C/T cg06671706 chr8:8559999 CLDN23 0.55 8.17 0.41 6.58e-15 Obesity-related traits; CRC cis rs1949733 1.000 rs2688223 chr4:8471398 T/C cg11789530 chr4:8429930 ACOX3 0.81 11.79 0.55 5.12e-27 Response to antineoplastic agents; CRC cis rs853679 0.760 rs9295768 chr6:28209102 G/A cg15786705 chr6:28176104 NA 0.62 6.67 0.34 1.11e-10 Depression; CRC trans rs7267979 1.000 rs2482928 chr20:25331530 A/G cg17903999 chr18:56338584 MALT1 0.42 6.97 0.36 1.73e-11 Liver enzyme levels (alkaline phosphatase); CRC cis rs8014204 0.566 rs11629369 chr14:75162021 G/A cg03030879 chr14:75389066 RPS6KL1 -0.4 -6.32 -0.33 8.72e-10 Caffeine consumption; CRC cis rs2275731 0.505 rs7894216 chr10:16479251 C/G cg04254609 chr10:16479192 PTER -0.58 -8.65 -0.43 2.23e-16 Bone fracture in osteoporosis; CRC cis rs5758511 0.680 rs34107327 chr22:42648353 T/G cg00645731 chr22:42541494 CYP2D7P1 0.66 10.22 0.49 1.82e-21 Birth weight; CRC cis rs12701220 0.655 rs10215292 chr7:1135263 A/G cg02733842 chr7:1102375 C7orf50 -0.6 -7.39 -0.38 1.25e-12 Bronchopulmonary dysplasia; CRC cis rs2180341 0.781 rs877102 chr6:127587086 T/C cg24812749 chr6:127587940 RNF146 0.74 10.76 0.51 2.38e-23 Breast cancer; CRC trans rs1499614 1.000 rs60326618 chr7:66166358 G/A cg10756647 chr7:56101905 PSPH 0.77 8.1 0.41 1.09e-14 Gout; CRC cis rs1552244 1.000 rs9881859 chr3:10072814 A/T cg08888203 chr3:10149979 C3orf24 0.69 9.55 0.47 3.13e-19 Alzheimer's disease; CRC cis rs2188554 0.740 rs213945 chr7:117190703 A/G cg09181792 chr7:117119393 CFTR -0.33 -6.09 -0.32 3.12e-9 Esophageal adenocarcinoma; CRC cis rs950027 0.620 rs1145089 chr15:45652054 G/C cg10760299 chr15:45669010 GATM 0.37 5.77 0.3 1.85e-8 Response to fenofibrate (adiponectin levels); CRC trans rs2303319 0.504 rs62189042 chr2:162602320 G/T cg18122310 chr12:50236657 BCDIN3D -0.73 -6.35 -0.33 7.23e-10 Cognitive function; CRC trans rs35110281 0.807 rs2838328 chr21:45023234 G/C cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.42 6.87 0.35 3.24e-11 Mean corpuscular volume; CRC cis rs1552244 0.938 rs67667957 chr3:10167264 G/C cg13047869 chr3:10149882 C3orf24 0.56 7.6 0.39 3.07e-13 Alzheimer's disease; CRC trans rs1005277 0.579 rs2474584 chr10:38416389 C/T cg23533926 chr12:111358616 MYL2 -0.53 -7.96 -0.4 2.83e-14 Extrinsic epigenetic age acceleration; CRC cis rs2412459 1.000 rs8023482 chr15:40307095 A/C cg02712587 chr15:40268421 EIF2AK4 -0.69 -5.86 -0.31 1.09e-8 Response to haloperidol in psychosis; CRC cis rs881375 0.715 rs11794516 chr9:123640230 A/G cg09586646 chr9:123605570 PSMD5;LOC253039 0.45 6.58 0.34 1.85e-10 Rheumatoid arthritis; CRC trans rs853679 0.546 rs200953 chr6:27837267 T/C cg06606381 chr12:133084897 FBRSL1 -0.73 -6.4 -0.33 5.31e-10 Depression; CRC cis rs4845875 0.626 rs7538516 chr1:11836682 C/T cg02448276 chr1:11845238 NA 0.36 5.61 0.3 4.38e-8 Midregional pro atrial natriuretic peptide levels; CRC cis rs6502050 0.835 rs4789665 chr17:80168097 A/C cg09264619 chr17:80180166 NA -0.36 -6.06 -0.32 3.63e-9 Life satisfaction; CRC cis rs10791323 0.592 rs2851115 chr11:133705381 C/A cg03690763 chr11:133734501 NA -0.36 -5.94 -0.31 7.17e-9 Childhood ear infection; CRC cis rs40363 0.645 rs1690446 chr16:3519009 T/C cg21433313 chr16:3507492 NAT15 0.61 8.68 0.43 1.9e-16 Tuberculosis; CRC cis rs7618915 0.501 rs3755798 chr3:52741160 G/A cg08222913 chr3:52553049 STAB1 -0.32 -5.91 -0.31 8.52e-9 Bipolar disorder; CRC cis rs4713118 0.621 rs4713134 chr6:28034121 T/C cg02631126 chr6:28058918 ZSCAN12L1 0.28 5.95 0.31 6.79e-9 Parkinson's disease; CRC trans rs925098 0.577 rs2724470 chr4:17996046 A/G cg05258489 chr8:61593179 CHD7 -0.44 -6.29 -0.33 1.01e-9 Birth weight;Height; CRC cis rs2976388 0.609 rs2585140 chr8:143806896 A/G cg24046110 chr8:143859143 LYNX1 0.48 8.33 0.42 2.27e-15 Urinary tract infection frequency; CRC cis rs561341 1.000 rs497479 chr17:30328605 C/T cg00745463 chr17:30367425 LRRC37B -0.86 -9.53 -0.47 3.61e-19 Hip circumference adjusted for BMI; CRC cis rs9911578 0.967 rs9894274 chr17:56977919 G/A cg12560992 chr17:57184187 TRIM37 0.92 16.88 0.68 1.74e-46 Intelligence (multi-trait analysis); CRC trans rs7267979 1.000 rs4813562 chr20:25352588 G/A cg17903999 chr18:56338584 MALT1 0.42 6.94 0.36 2.1e-11 Liver enzyme levels (alkaline phosphatase); CRC cis rs1865760 0.613 rs9379801 chr6:25901711 T/C cg12310025 chr6:25882481 NA -0.47 -7.16 -0.37 5.39e-12 Height; CRC cis rs6589219 0.954 rs3802840 chr11:111171646 G/T cg25129781 chr11:111156908 C11orf53 0.31 5.64 0.3 3.66e-8 Colorectal cancer; CRC cis rs6951245 0.935 rs79143504 chr7:1110212 A/G cg03188948 chr7:1209495 NA 0.64 6.46 0.34 3.75e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs362296 0.511 rs2051558 chr4:3324886 G/A cg08741688 chr4:3415352 RGS12 -0.36 -5.74 -0.3 2.2e-8 Parental longevity (mother's age at death); CRC cis rs2179367 0.959 rs579789 chr6:149679371 A/G cg07828024 chr6:149772892 ZC3H12D -0.37 -6.04 -0.32 4.14e-9 Dupuytren's disease; CRC cis rs748404 0.578 rs4547312 chr15:43632138 A/G cg02155558 chr15:43621948 ADAL;LCMT2 0.52 7.65 0.39 2.31e-13 Lung cancer; CRC cis rs1005277 0.579 rs2474567 chr10:38382492 C/T cg25427524 chr10:38739819 LOC399744 -0.77 -13.65 -0.6 6.29e-34 Extrinsic epigenetic age acceleration; CRC cis rs447735 0.587 rs11647958 chr16:89720909 A/T cg03605463 chr16:89740564 NA 0.45 7.37 0.38 1.35e-12 Hemoglobin concentration; CRC cis rs9916302 0.706 rs667239 chr17:37442241 A/G cg15445000 chr17:37608096 MED1 -0.39 -7.09 -0.36 8.1e-12 Glomerular filtration rate (creatinine); CRC cis rs2281845 0.507 rs11589642 chr1:201100748 A/G cg08885800 chr1:201084119 NA -0.4 -5.71 -0.3 2.57e-8 Permanent tooth development; CRC cis rs870825 0.616 rs2003994 chr4:185636568 G/T cg04058563 chr4:185651563 MLF1IP 0.73 9.38 0.46 1.13e-18 Blood protein levels; CRC cis rs9303542 0.559 rs8079617 chr17:46610028 T/G cg04904318 chr17:46607828 HOXB1 -0.54 -6.3 -0.33 9.71e-10 Ovarian cancer;Epithelial ovarian cancer; CRC trans rs2303319 0.504 rs56026147 chr2:162614089 T/C cg23247704 chr1:116518985 SLC22A15 -0.72 -6.14 -0.32 2.42e-9 Cognitive function; CRC cis rs9649213 0.574 rs62478236 chr7:98030377 G/A cg08684580 chr7:98029266 BAIAP2L1 -0.33 -5.83 -0.31 1.32e-8 Prostate cancer (SNP x SNP interaction); CRC trans rs2303319 0.504 rs12467613 chr2:162603216 G/T cg14875682 chr5:52083620 ITGA1;PELO -0.73 -6.16 -0.32 2.11e-9 Cognitive function; CRC cis rs10504229 0.683 rs61306359 chr8:58134646 G/A cg21724239 chr8:58056113 NA 0.49 6.81 0.35 4.75e-11 Developmental language disorder (linguistic errors); CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg04015759 chr2:27718181 FNDC4 -0.36 -6.03 -0.32 4.41e-9 Myopia (pathological); CRC cis rs6429082 0.755 rs291384 chr1:235644300 C/T cg26050004 chr1:235667680 B3GALNT2 0.59 8.1 0.41 1.11e-14 Adiposity; CRC cis rs2576037 0.526 rs10853547 chr18:44530548 A/C cg24750912 chr18:44543259 TCEB3CL;KATNAL2 0.3 5.96 0.31 6.43e-9 Personality dimensions; CRC cis rs2806561 0.765 rs679591 chr1:23499916 T/C cg12483005 chr1:23474871 LUZP1 0.51 7.32 0.37 1.87e-12 Height; CRC cis rs4077468 1.000 rs11801695 chr1:205916175 A/C cg13172432 chr1:205912842 SLC26A9 0.34 5.71 0.3 2.48e-8 Cystic fibrosis-related diabetes; CRC cis rs7224737 1.000 rs9889618 chr17:40293467 C/T cg02228675 chr17:40259724 DHX58 -0.48 -6.8 -0.35 5.05e-11 Fibrinogen levels; CRC cis rs694739 0.657 rs11231770 chr11:64140625 G/A cg02228329 chr11:64053129 BAD;GPR137 0.5 6.79 0.35 5.31e-11 Alopecia areata;Crohn's disease;Psoriasis vulgaris; CRC cis rs1451375 1.000 rs2329341 chr7:50620275 A/C cg14593290 chr7:50529359 DDC 0.57 7.89 0.4 4.57e-14 Malaria; CRC cis rs9914988 0.673 rs9890212 chr17:27169890 G/C cg16670446 chr17:27188758 MIR451;MIR144 0.55 8.67 0.43 1.97e-16 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs6558174 0.965 rs2009212 chr8:22491496 G/A cg03733263 chr8:22462867 KIAA1967 0.51 6.78 0.35 5.55e-11 Breast cancer; CRC cis rs10504229 0.683 rs10504221 chr8:58140256 A/G cg02725872 chr8:58115012 NA -0.64 -11.55 -0.54 3.85e-26 Developmental language disorder (linguistic errors); CRC cis rs2404602 0.536 rs11072599 chr15:76774508 T/C cg26408565 chr15:76604113 ETFA -0.36 -5.65 -0.3 3.56e-8 Blood metabolite levels; CRC cis rs4819052 0.918 rs34886433 chr21:46680538 G/C cg11663144 chr21:46675770 NA -0.78 -10.67 -0.51 4.89e-23 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs7590720 1.000 rs7592663 chr2:216894978 T/C cg12620499 chr2:216877984 MREG 0.87 14.34 0.62 1.51e-36 Alcohol dependence; CRC cis rs10876993 0.928 rs1628552 chr12:58082142 C/T cg15848620 chr12:58087721 OS9 -0.59 -8.1 -0.41 1.12e-14 Celiac disease or Rheumatoid arthritis; CRC cis rs1580019 0.563 rs34201720 chr7:32568935 G/A cg07520158 chr7:32535189 LSM5;AVL9 0.54 7.94 0.4 3.18e-14 Cognitive ability; CRC cis rs9648716 0.935 rs7791924 chr7:140578070 C/A cg10747023 chr7:140774559 NA 0.45 5.93 0.31 7.57e-9 Type 2 diabetes; CRC trans rs629535 0.508 rs56207225 chr8:70146628 C/A cg21567404 chr3:27674614 NA -0.9 -13.07 -0.58 9.76e-32 Dupuytren's disease; CRC cis rs9925964 0.687 rs12917722 chr16:30948397 A/G cg03418659 chr16:31128414 MYST1 0.44 6.27 0.33 1.11e-9 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs6547741 0.904 rs1528403 chr2:27846645 C/G cg27432699 chr2:27873401 GPN1 0.7 12.5 0.57 1.37e-29 Oral cavity cancer; CRC trans rs6601327 0.602 rs7820917 chr8:9647868 C/T cg16141378 chr3:129829833 LOC729375 -0.41 -6.1 -0.32 2.92e-9 Multiple myeloma (hyperdiploidy); CRC cis rs11758351 0.866 rs2069018 chr6:26205718 T/C cg01420254 chr6:26195488 NA 0.8 8.79 0.44 8.31e-17 Gout;Renal underexcretion gout; CRC cis rs2836974 0.681 rs8128827 chr21:40710547 C/T cg17971929 chr21:40555470 PSMG1 0.74 9.87 0.48 2.68e-20 Cognitive function; CRC cis rs9549328 0.731 rs2873371 chr13:113616242 C/T cg08614441 chr13:113633676 MCF2L -0.45 -7.84 -0.4 6.44e-14 Systolic blood pressure; CRC cis rs7726839 0.561 rs11955068 chr5:582324 C/T cg14541582 chr5:601475 NA -0.31 -6.54 -0.34 2.29e-10 Obesity-related traits; CRC trans rs1005277 0.557 rs1854563 chr10:38434961 G/A cg17830980 chr10:43048298 ZNF37B -0.59 -9.89 -0.48 2.25e-20 Extrinsic epigenetic age acceleration; CRC cis rs11758351 1.000 rs2143346 chr6:26198449 C/G cg01420254 chr6:26195488 NA -0.84 -8.8 -0.44 7.75e-17 Gout;Renal underexcretion gout; CRC cis rs7412746 0.611 rs2280627 chr1:150935872 A/G cg10589385 chr1:150898437 SETDB1 0.28 5.96 0.31 6.39e-9 Melanoma; CRC cis rs9322193 0.923 rs9322196 chr6:149940781 T/G cg00933542 chr6:150070202 PCMT1 0.3 6.36 0.33 6.66e-10 Lung cancer; CRC cis rs9322817 0.691 rs2034821 chr6:105219537 C/T cg02098413 chr6:105308735 HACE1 -0.44 -8.51 -0.42 6.38e-16 Thyroid stimulating hormone; CRC cis rs4819052 0.851 rs13050359 chr21:46672671 T/G cg02159808 chr21:46707872 POFUT2;LOC642852 0.5 6.67 0.35 1.05e-10 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs2281845 0.965 rs3738263 chr1:201083506 A/G cg17810781 chr1:201082982 CACNA1S 0.49 8.37 0.42 1.7e-15 Permanent tooth development; CRC cis rs4563143 0.675 rs73025085 chr19:29247018 C/A cg12667521 chr19:29218732 NA 0.49 7.49 0.38 6.26e-13 Methadone dose in opioid dependence; CRC trans rs459571 0.920 rs433402 chr9:136898627 A/G cg09836344 chr4:1243392 C4orf42;CTBP1 -0.81 -11.01 -0.52 3.39e-24 Platelet distribution width; CRC cis rs9462027 0.628 rs2764206 chr6:34712900 G/A cg07306190 chr6:34760872 UHRF1BP1 -0.35 -6.24 -0.33 1.36e-9 Systemic lupus erythematosus; CRC cis rs36715 1.000 rs36705 chr5:127554486 A/G cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.6 7.66 0.39 2.14e-13 Breast cancer; CRC cis rs11792861 0.926 rs10512391 chr9:111809530 A/G cg05043794 chr9:111880884 C9orf5 -0.35 -6.32 -0.33 8.36e-10 Menarche (age at onset); CRC cis rs875971 0.545 rs316328 chr7:65608838 A/G cg11764359 chr7:65958608 NA -0.46 -6.22 -0.32 1.49e-9 Aortic root size; CRC cis rs73206853 0.563 rs73194050 chr12:111200634 T/C cg12870014 chr12:110450643 ANKRD13A 0.72 8.18 0.41 6.16e-15 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC cis rs55665837 1.000 rs10047457 chr11:14439459 T/A cg19336497 chr11:14380999 RRAS2 -0.39 -6.73 -0.35 7.56e-11 Vitamin D levels; CRC cis rs2457480 0.852 rs61857485 chr10:44719292 C/T cg09554077 chr10:44749378 NA 0.65 7.29 0.37 2.37e-12 Coronary artery disease; CRC cis rs4253772 0.550 rs6007761 chr22:46670394 C/T cg03482458 chr22:46692211 CN5H6.4;GTSE1 -0.54 -7.28 -0.37 2.41e-12 LDL cholesterol;Cholesterol, total; CRC cis rs9322193 0.923 rs9767554 chr6:149937996 T/C cg07701084 chr6:150067640 NUP43 0.53 7.69 0.39 1.69e-13 Lung cancer; CRC cis rs9814567 0.762 rs13071852 chr3:134223217 C/G cg06109529 chr3:134205091 CEP63;ANAPC13 0.7 8.78 0.44 9.26e-17 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs832540 0.629 rs10055224 chr5:56081201 C/T cg20203395 chr5:56204925 C5orf35 0.41 5.7 0.3 2.73e-8 Coronary artery disease; CRC cis rs1577917 0.654 rs9450284 chr6:86199329 G/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A 0.49 7.04 0.36 1.15e-11 Response to antipsychotic treatment; CRC cis rs35306767 0.953 rs12354639 chr10:963681 G/A cg20503657 chr10:835505 NA 0.79 10.08 0.49 5.16e-21 Eosinophil percentage of granulocytes; CRC cis rs2731664 0.792 rs2545795 chr5:176887106 A/C cg23176889 chr5:176863531 GRK6 -0.75 -16.49 -0.67 6.01e-45 Intelligence (multi-trait analysis); CRC cis rs1577917 1.000 rs7747824 chr6:86647106 G/A cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.51 -6.86 -0.35 3.38e-11 Response to antipsychotic treatment; CRC cis rs644799 1.000 rs644799 chr11:95564259 A/G cg25622487 chr11:95524042 FAM76B;CEP57 0.76 12.0 0.55 9.41e-28 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs12188164 1.000 rs56042615 chr5:437667 G/A cg26850624 chr5:429559 AHRR -0.81 -13.83 -0.61 1.3e-34 Cystic fibrosis severity; CRC trans rs2303319 0.504 rs12465734 chr2:162437859 A/G cg09481857 chr22:21368659 P2RX6;MGC16703 -0.65 -6.0 -0.31 5.13e-9 Cognitive function; CRC trans rs12408261 0.843 rs7544452 chr1:189313343 A/G cg20050113 chr2:103236861 SLC9A2 0.25 6.04 0.32 4.08e-9 Number of pregnancies; CRC cis rs908922 0.676 rs493133 chr1:152493875 G/C cg09873164 chr1:152488093 CRCT1 0.37 6.26 0.33 1.18e-9 Hair morphology; CRC cis rs11098499 0.580 rs12509234 chr4:120319434 T/C cg09307838 chr4:120376055 NA 0.71 10.89 0.51 8.42e-24 Corneal astigmatism; CRC cis rs6754459 0.694 rs4404281 chr2:3706055 C/T cg00999904 chr2:3704751 ALLC -0.45 -6.68 -0.35 1.05e-10 Response to inhaled corticosteroid treatment in asthma (change in FEV1); CRC trans rs4263408 0.934 rs9683743 chr4:39703194 A/C cg06479426 chr20:61274286 SLCO4A1 -0.41 -6.0 -0.31 5.19e-9 Plasma amyloid beta peptide concentrations (ABx-40); CRC cis rs6840360 0.642 rs2724580 chr4:152372505 A/G cg09659197 chr4:152720779 NA 0.33 6.46 0.34 3.69e-10 Intelligence (multi-trait analysis); CRC cis rs300703 0.935 rs300755 chr2:228505 C/T cg21211680 chr2:198530 NA 0.99 8.46 0.42 8.82e-16 Blood protein levels; CRC cis rs7762018 1.000 rs6912959 chr6:170126224 G/A cg24289452 chr6:170231220 NA -0.58 -6.58 -0.34 1.81e-10 Thiazide-induced adverse metabolic effects in hypertensive patients; CRC cis rs1950626 0.623 rs4402490 chr14:101445453 A/G cg02351406 chr14:101447389 SNORD114-20;SNORD114-21 -0.76 -11.94 -0.55 1.55e-27 Pelvic organ prolapse (moderate/severe); CRC cis rs4711336 0.712 rs942641 chr6:33687007 G/A cg14003231 chr6:33640908 ITPR3 0.4 6.48 0.34 3.44e-10 Height; CRC cis rs4713118 0.513 rs149955 chr6:28036225 G/C cg10876282 chr6:28092338 ZSCAN16 0.46 6.1 0.32 3e-9 Parkinson's disease; CRC cis rs2180341 0.618 rs12529077 chr6:127634244 G/T cg24812749 chr6:127587940 RNF146 0.65 9.67 0.47 1.22e-19 Breast cancer; CRC cis rs4713118 0.513 rs149958 chr6:28013617 A/C cg21251018 chr6:28226885 NKAPL 0.48 7.4 0.38 1.14e-12 Parkinson's disease; CRC cis rs12477438 0.572 rs10170063 chr2:99655639 A/C cg26064155 chr2:99771622 LIPT1;TSGA10 -0.63 -8.55 -0.43 4.61e-16 Chronic sinus infection; CRC cis rs9381040 0.610 rs6940462 chr6:41020223 G/A cg25110423 chr6:41068646 NFYA;LOC221442 -0.38 -5.83 -0.31 1.29e-8 Alzheimer's disease (late onset); CRC cis rs12950390 0.853 rs12450733 chr17:45855404 A/G cg24803719 chr17:45855879 NA -0.31 -6.92 -0.36 2.34e-11 IgG glycosylation; CRC cis rs3931020 0.530 rs12125889 chr1:75241971 A/G cg21535942 chr1:75199100 CRYZ;TYW3 0.43 5.64 0.3 3.58e-8 Resistin levels; CRC cis rs7208859 0.623 rs78071511 chr17:29128154 C/T cg13385521 chr17:29058706 SUZ12P 0.74 8.44 0.42 9.97e-16 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs10193935 0.901 rs13022188 chr2:42704423 A/C cg27598129 chr2:42591480 NA 0.68 7.65 0.39 2.23e-13 Colonoscopy-negative controls vs population controls; CRC cis rs514406 0.698 rs567880 chr1:53348564 T/G cg24675658 chr1:53192096 ZYG11B -0.68 -10.19 -0.49 2.33e-21 Monocyte count; CRC cis rs28374715 0.609 rs8043237 chr15:41514298 G/A cg18705301 chr15:41695430 NDUFAF1 -0.88 -13.33 -0.59 1.08e-32 Ulcerative colitis; CRC cis rs10256972 0.577 rs4999286 chr7:1199506 C/G cg23708337 chr7:1209742 NA 0.51 7.83 0.4 6.66e-14 Longevity;Endometriosis; CRC cis rs11209185 0.509 rs9436356 chr1:68447202 A/G cg22082780 chr1:68452167 NA 0.41 6.11 0.32 2.8e-9 Itch intensity from mosquito bite adjusted by bite size; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg09467605 chr19:2785488 THOP1 0.45 6.14 0.32 2.41e-9 Anxiety disorder; CRC cis rs4713118 0.513 rs1225591 chr6:28148752 G/A cg25164649 chr6:28176230 NA 0.65 9.23 0.45 3.45e-18 Parkinson's disease; CRC cis rs5769765 1.000 rs761879 chr22:50241210 G/A cg08270630 chr22:50330655 NA 0.4 5.9 0.31 8.85e-9 Schizophrenia; CRC cis rs6502050 0.835 rs6502077 chr17:80122966 G/C cg25804541 chr17:80189381 SLC16A3 -0.31 -5.95 -0.31 6.84e-9 Life satisfaction; CRC trans rs17270561 0.609 rs1165211 chr6:25800922 T/C cg02936872 chr9:99801550 CTSL2 0.48 6.22 0.32 1.48e-9 Iron status biomarkers; CRC cis rs2425143 0.908 rs11697087 chr20:34427583 G/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.53 -5.84 -0.31 1.26e-8 Blood protein levels; CRC cis rs3785574 0.924 rs2584641 chr17:61862889 A/G cg25654072 chr17:61904446 PSMC5;FTSJ3 0.43 6.0 0.31 5.12e-9 Height; CRC cis rs9322193 0.923 rs7767622 chr6:150002902 T/C cg07701084 chr6:150067640 NUP43 0.56 8.2 0.41 5.45e-15 Lung cancer; CRC cis rs9443645 0.901 rs1890229 chr6:79695029 C/T cg09184832 chr6:79620586 NA -0.51 -9.15 -0.45 5.94e-18 Intelligence (multi-trait analysis); CRC cis rs11792861 0.926 rs76689835 chr9:111833792 G/A cg05043794 chr9:111880884 C9orf5 -0.37 -6.63 -0.34 1.36e-10 Menarche (age at onset); CRC cis rs8060686 0.641 rs78537727 chr16:68120606 A/G cg08314208 chr16:67682810 RLTPR -0.55 -5.96 -0.31 6.57e-9 HDL cholesterol;Metabolic syndrome; CRC cis rs6960043 0.748 rs10228561 chr7:15063961 C/T cg19272540 chr7:15055459 NA -0.22 -5.91 -0.31 8.61e-9 Type 2 diabetes; CRC trans rs8123881 0.733 rs7268466 chr20:15810676 C/T cg25428213 chr17:80929211 B3GNTL1 -0.52 -5.98 -0.31 5.77e-9 Body mass index; CRC trans rs66759488 0.739 rs10851451 chr15:47608991 A/G cg00685614 chr16:89118838 NA -0.26 -6.28 -0.33 1.09e-9 Lung cancer; CRC cis rs477895 0.713 rs11607165 chr11:63963947 T/G cg19465662 chr11:63993652 NUDT22;TRPT1 0.73 8.97 0.44 2.31e-17 Mean platelet volume; CRC cis rs4713118 0.513 rs149941 chr6:28001033 T/C cg10876282 chr6:28092338 ZSCAN16 0.47 6.37 0.33 6.53e-10 Parkinson's disease; CRC cis rs7113874 0.569 rs10840072 chr11:8569360 T/C cg17679104 chr11:8615758 STK33 -0.35 -5.91 -0.31 8.67e-9 Body mass index in physically active individuals;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs2398893 0.596 rs13299181 chr9:96887457 G/A cg14459158 chr9:96720562 NA 0.45 6.42 0.33 4.79e-10 Waist-hip ratio;Waist-to-hip ratio adjusted for body mass index; CRC cis rs1153858 1.000 rs2056493 chr15:45648272 A/G cg14582100 chr15:45693742 SPATA5L1 0.29 6.0 0.31 5.17e-9 Homoarginine levels; CRC cis rs747650 0.892 rs2029298 chr11:47234718 C/T cg03339077 chr11:47165057 C11orf49 0.45 6.36 0.33 6.59e-10 Acne (severe); CRC cis rs6752107 0.967 rs10210302 chr2:234158839 C/T cg07618928 chr2:234183455 ATG16L1;SCARNA5 0.65 11.42 0.53 1.17e-25 Crohn's disease;Inflammatory bowel disease; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg04787407 chr4:99916511 METAP1 0.52 6.68 0.35 1.01e-10 Thyroid stimulating hormone; CRC cis rs12134245 0.747 rs35654098 chr1:92001452 T/A cg21854759 chr1:92012499 NA -0.53 -8.79 -0.44 8.36e-17 Breast cancer; CRC cis rs812925 0.537 rs10196146 chr2:61605379 C/A cg10580144 chr2:61372316 C2orf74 -0.33 -7.23 -0.37 3.43e-12 Immature fraction of reticulocytes; CRC cis rs477895 0.838 rs12794145 chr11:64006484 C/T cg04317338 chr11:64019027 PLCB3 0.72 8.67 0.43 1.99e-16 Mean platelet volume; CRC cis rs4713118 0.621 rs4713132 chr6:28034035 A/G cg06470822 chr6:28175283 NA 0.94 12.8 0.58 1.0500000000000001e-30 Parkinson's disease; CRC cis rs12541335 0.639 rs13257108 chr8:22165043 T/C cg14487702 chr8:22132665 PIWIL2 0.37 5.62 0.3 4.07e-8 Hypertriglyceridemia; CRC cis rs6908034 0.607 rs76245225 chr6:19813188 T/G cg02682789 chr6:19804855 NA 0.81 6.48 0.34 3.35e-10 Endometriosis;Deep ovarian and/or rectovaginal disease with dense adhesions; CRC cis rs1215050 0.740 rs783941 chr4:99008235 T/C cg05340658 chr4:99064831 C4orf37 -0.48 -7.34 -0.38 1.65e-12 Waist-to-hip ratio adjusted for body mass index; CRC cis rs4927850 0.957 rs4927851 chr3:195751853 A/G cg01181863 chr3:195395398 SDHAP2 -0.57 -7.97 -0.4 2.67e-14 Pancreatic cancer; CRC cis rs738322 0.775 rs4375 chr22:38539041 T/C cg17652424 chr22:38574118 PLA2G6 -0.18 -5.65 -0.3 3.49e-8 Cutaneous nevi; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg12646931 chr5:89770577 MBLAC2;POLR3G 0.46 6.2 0.32 1.7e-9 Anxiety disorder; CRC cis rs9322193 0.923 rs35967444 chr6:149996724 G/A cg00933542 chr6:150070202 PCMT1 0.3 6.18 0.32 1.89e-9 Lung cancer; CRC cis rs2549003 1.000 rs2070726 chr5:131821738 C/A cg21138405 chr5:131827807 IRF1 0.57 11.38 0.53 1.59e-25 Asthma (sex interaction); CRC cis rs919433 0.680 rs2244271 chr2:198286581 C/T cg10820045 chr2:198174542 NA 0.39 6.55 0.34 2.2e-10 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC cis rs4731207 0.596 rs6466965 chr7:124579726 A/G cg23710748 chr7:124431027 NA -0.39 -6.12 -0.32 2.71e-9 Cutaneous malignant melanoma; CRC cis rs4282054 0.631 rs13081155 chr3:52732429 A/G cg08222913 chr3:52553049 STAB1 -0.38 -7.28 -0.37 2.51e-12 Cognitive function; CRC cis rs1862618 0.853 rs860580 chr5:56149429 G/T cg12311346 chr5:56204834 C5orf35 0.76 10.03 0.48 7.6e-21 Initial pursuit acceleration; CRC cis rs875971 0.862 rs4149461 chr7:65744732 T/C cg12463550 chr7:65579703 CRCP -0.52 -7.39 -0.38 1.23e-12 Aortic root size; CRC cis rs6499255 0.638 rs57824734 chr16:69811995 C/T cg15192750 chr16:69999425 NA 0.55 7.38 0.38 1.3e-12 IgE levels; CRC cis rs711830 1.000 rs711830 chr2:177037311 C/T cg13092806 chr2:177043255 NA -0.73 -9.3 -0.46 2.08e-18 Serous invasive ovarian cancer;Epithelial ovarian cancer;Invasive epithelial ovarian cancer;Mucinous ovarian carcinoma;Low-grade serous and serous borderline ovarian cancer;Serous borderline ovarian cancer;High-grade serous ovarian cancer; CRC cis rs6743376 0.556 rs6748448 chr2:113819419 A/G cg09040174 chr2:113837401 NA 0.44 6.44 0.33 4.3e-10 Inflammatory biomarkers; CRC cis rs2816062 0.786 rs2816055 chr1:18898248 A/G cg18795169 chr1:18902165 NA -0.92 -19.57 -0.73 4.35e-57 Urate levels in lean individuals; CRC cis rs919433 0.963 rs12618612 chr2:198171058 G/T cg10820045 chr2:198174542 NA -0.55 -9.29 -0.46 2.12e-18 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC cis rs11971779 0.680 rs2355786 chr7:139065622 A/C cg07862535 chr7:139043722 LUC7L2 -0.61 -7.8 -0.4 8.13e-14 Diisocyanate-induced asthma; CRC cis rs4824093 0.610 rs12168949 chr22:50317714 A/G cg22709217 chr22:50311962 ALG12;CRELD2 -0.92 -8.61 -0.43 2.99e-16 Amyotrophic lateral sclerosis (sporadic); CRC cis rs11112613 0.713 rs11112589 chr12:105951226 C/G cg03607813 chr12:105948248 NA -0.78 -10.92 -0.52 7.02e-24 Corrected insulin response;Corrected insulin response adjusted for insulin sensitivity index; CRC cis rs2204008 0.522 rs12370263 chr12:38113311 A/G cg26384229 chr12:38710491 ALG10B 0.66 8.92 0.44 3.24e-17 Bladder cancer; CRC cis rs9368481 0.546 rs12664610 chr6:26885031 G/A cg12292205 chr6:26970375 C6orf41 0.63 9.91 0.48 1.94e-20 Autism spectrum disorder or schizophrenia; CRC cis rs10751667 1.000 rs7396366 chr11:986185 C/A cg01483505 chr11:975446 AP2A2 0.4 6.1 0.32 2.93e-9 Alzheimer's disease (late onset); CRC cis rs2617583 0.967 rs2617595 chr5:1448246 C/T cg07151155 chr5:1473589 LPCAT1 -0.42 -6.5 -0.34 2.9e-10 Breast cancer; CRC cis rs875971 0.895 rs3857684 chr7:65938158 G/C cg12463550 chr7:65579703 CRCP 0.48 6.94 0.36 2.12e-11 Aortic root size; CRC cis rs6502050 0.871 rs9916649 chr17:80075739 G/A cg25804541 chr17:80189381 SLC16A3 0.32 6.13 0.32 2.51e-9 Life satisfaction; CRC cis rs853679 0.517 rs9393895 chr6:28127621 T/C cg15786705 chr6:28176104 NA 0.78 9.75 0.47 6.51e-20 Depression; CRC cis rs60843830 0.633 rs1078763 chr2:113763 A/G cg25945732 chr2:264204 ACP1;SH3YL1 -0.44 -6.49 -0.34 3.22e-10 Spherical equivalent (joint analysis main effects and education interaction); CRC cis rs6089584 0.816 rs6061411 chr20:60634716 C/A cg12751644 chr20:60527061 NA -0.37 -5.67 -0.3 3.08e-8 Body mass index; CRC cis rs875971 0.862 rs1860469 chr7:66106875 A/G cg00343986 chr7:65444356 GUSB -0.46 -6.41 -0.33 5.12e-10 Aortic root size; CRC cis rs4638749 0.677 rs10190865 chr2:108843624 T/C cg25838818 chr2:108905173 SULT1C2 -0.33 -5.61 -0.3 4.35e-8 Blood pressure; CRC cis rs3741151 0.773 rs73542979 chr11:73127526 G/C cg17517138 chr11:73019481 ARHGEF17 0.92 7.7 0.39 1.63e-13 GIP levels in response to oral glucose tolerance test (120 minutes); CRC cis rs10905065 0.895 rs1567707 chr10:5853817 G/C cg11519256 chr10:5708881 ASB13 -0.44 -6.3 -0.33 9.4e-10 Menopause (age at onset); CRC cis rs722599 0.748 rs17102884 chr14:75374899 C/T cg08847533 chr14:75593920 NEK9 -0.46 -6.19 -0.32 1.84e-9 IgG glycosylation; CRC cis rs57590327 0.503 rs9852235 chr3:81508355 A/G cg07356753 chr3:81810745 GBE1 0.43 5.66 0.3 3.36e-8 Extraversion; CRC cis rs8017423 0.647 rs4904680 chr14:90822075 C/T cg14092571 chr14:90743983 NA 0.39 6.02 0.32 4.62e-9 Mortality in heart failure; CRC cis rs2404602 0.669 rs17367297 chr15:77158026 A/C cg22467129 chr15:76604101 ETFA -0.37 -5.97 -0.31 6.27e-9 Blood metabolite levels; CRC cis rs6500602 0.674 rs7191664 chr16:4541924 T/C cg14951292 chr16:4525986 HMOX2;NMRAL1 0.73 10.41 0.5 4.02e-22 Schizophrenia; CRC cis rs5769765 0.908 rs138867 chr22:50207703 A/G cg22709217 chr22:50311962 ALG12;CRELD2 0.78 10.87 0.51 1.04e-23 Schizophrenia; CRC cis rs4144743 0.938 rs55677902 chr17:45322572 G/T cg18085866 chr17:45331354 ITGB3 -0.61 -8.3 -0.42 2.78e-15 Body mass index; CRC cis rs360798 0.512 rs12989754 chr2:63020970 A/G cg17519650 chr2:63277830 OTX1 -0.43 -6.14 -0.32 2.36e-9 Coronary artery disease; CRC cis rs12541335 0.639 rs4871994 chr8:22206038 G/A cg27266060 chr8:22091797 NA 0.36 5.99 0.31 5.53e-9 Hypertriglyceridemia; CRC cis rs7937682 0.632 rs14133 chr11:111782697 C/G cg19812747 chr11:111475976 SIK2 0.44 6.43 0.33 4.57e-10 Primary sclerosing cholangitis; CRC cis rs9814567 1.000 rs4309773 chr3:134277301 G/A cg06109529 chr3:134205091 CEP63;ANAPC13 -0.81 -12.16 -0.56 2.46e-28 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs644799 0.509 rs561635 chr11:95634232 C/T cg03916912 chr11:95522834 CEP57;FAM76B -0.6 -9.53 -0.47 3.64e-19 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs7827545 0.545 rs6578228 chr8:135562422 G/A cg17885191 chr8:135476712 NA 0.65 7.57 0.39 3.69e-13 Hypertension (SNP x SNP interaction); CRC cis rs311392 0.902 rs1511147 chr8:55091227 C/T cg06042504 chr8:55087323 NA -0.41 -6.28 -0.33 1.08e-9 Pelvic organ prolapse (moderate/severe); CRC cis rs7208859 0.573 rs8070182 chr17:29135594 A/C cg01831904 chr17:28903510 LRRC37B2 -0.55 -5.63 -0.3 3.93e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs539514 0.664 rs479824 chr13:76308360 C/T cg04757411 chr13:76259545 LMO7 -0.35 -5.84 -0.31 1.27e-8 Type 1 diabetes; CRC cis rs400736 0.655 rs11121086 chr1:8151224 C/T cg25007680 chr1:8021821 PARK7 -0.45 -6.23 -0.32 1.43e-9 Response to antidepressants and depression; CRC cis rs9648716 1.000 rs1267646 chr7:140485690 C/T cg10747023 chr7:140774559 NA 0.44 5.67 0.3 3.14e-8 Type 2 diabetes; CRC cis rs477692 0.569 rs10764883 chr10:131307817 A/G cg05714579 chr10:131428358 MGMT 0.54 7.6 0.39 3.22e-13 Response to temozolomide; CRC cis rs7202877 0.610 rs3844219 chr16:75370230 G/T cg03315344 chr16:75512273 CHST6 0.46 5.64 0.3 3.69e-8 Type 2 diabetes;Type 1 diabetes; CRC cis rs8044995 0.563 rs56331745 chr16:68368770 G/T cg09835421 chr16:68378352 PRMT7 -0.77 -8.03 -0.4 1.78e-14 Schizophrenia; CRC trans rs9676308 1.000 rs8110638 chr19:57569719 C/T cg17664269 chr3:3080621 CNTN4 -0.65 -5.96 -0.31 6.48e-9 Colorectal cancer; CRC cis rs4665809 1.000 rs4233709 chr2:26291493 C/T cg26119090 chr2:26468346 HADHA;HADHB 0.56 7.29 0.37 2.3e-12 Gut microbiome composition (summer); CRC cis rs12325245 0.536 rs34676074 chr16:58549321 G/C cg02549819 chr16:58548995 SETD6 1.29 8.25 0.41 3.97e-15 Schizophrenia; CRC trans rs11098499 0.731 rs6846966 chr4:120293208 A/G cg25214090 chr10:38739885 LOC399744 0.62 9.89 0.48 2.35e-20 Corneal astigmatism; CRC trans rs6940638 1.000 rs6940638 chr6:27046250 A/G cg06606381 chr12:133084897 FBRSL1 -0.57 -6.11 -0.32 2.81e-9 Intelligence (multi-trait analysis); CRC cis rs62229266 0.771 rs11701590 chr21:37384730 A/C cg12218747 chr21:37451666 NA -0.43 -7.34 -0.38 1.68e-12 Mitral valve prolapse; CRC cis rs4664293 0.967 rs7559127 chr2:160515935 T/C cg08347373 chr2:160653686 CD302 -0.37 -6.15 -0.32 2.21e-9 Monocyte percentage of white cells; CRC cis rs6951245 1.000 rs78896566 chr7:1080182 C/G cg22907277 chr7:1156413 C7orf50 0.72 7.47 0.38 7.14e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs8180040 1.000 rs11714294 chr3:47339723 G/A cg02527881 chr3:46936655 PTH1R 0.39 7.12 0.37 6.68e-12 Colorectal cancer; CRC cis rs11212617 0.967 rs374443 chr11:108221665 C/G cg01991180 chr11:108092276 ATM;NPAT 0.41 5.97 0.31 6.25e-9 Response to metformin in type 2 diabetes (glycemic); CRC cis rs60843830 1.000 rs3791220 chr2:227066 C/T cg00108164 chr2:264199 ACP1;SH3YL1 0.64 10.2 0.49 2.06e-21 Spherical equivalent (joint analysis main effects and education interaction); CRC cis rs57221529 0.709 rs111352378 chr5:577079 G/A cg14541582 chr5:601475 NA -0.37 -7.13 -0.37 6.35e-12 Lung disease severity in cystic fibrosis; CRC cis rs2953145 0.568 rs1133352 chr2:241522252 A/G cg07929629 chr2:241523174 NA -0.65 -10.05 -0.48 6.49e-21 Bipolar disorder; CRC cis rs7647973 0.626 rs35129566 chr3:49866584 T/G cg13072238 chr3:49761600 GMPPB 0.5 5.79 0.3 1.68e-8 Menarche (age at onset); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg23628684 chr21:30446052 CCT8 0.44 6.2 0.32 1.72e-9 Response to antipsychotic treatment; CRC cis rs9467711 0.538 rs13214169 chr6:25890656 A/G cg16898833 chr6:26189333 HIST1H4D 0.67 5.9 0.31 8.83e-9 Autism spectrum disorder or schizophrenia; CRC cis rs7208859 0.623 rs11657391 chr17:29194287 G/A cg14008862 chr17:28927542 LRRC37B2 0.55 5.74 0.3 2.12e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs9322193 0.884 rs7450246 chr6:150023653 C/T cg07701084 chr6:150067640 NUP43 0.61 9.12 0.45 7.81e-18 Lung cancer; CRC cis rs9814567 1.000 rs7619451 chr3:134233238 A/C cg06541857 chr3:134203789 ANAPC13;CEP63 -0.42 -5.94 -0.31 7.2e-9 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs881375 0.678 rs10118357 chr9:123680068 C/T cg09586646 chr9:123605570 PSMD5;LOC253039 0.46 7.03 0.36 1.23e-11 Rheumatoid arthritis; CRC cis rs9911578 0.935 rs420878 chr17:56709077 A/G cg12560992 chr17:57184187 TRIM37 0.91 16.61 0.68 2.07e-45 Intelligence (multi-trait analysis); CRC cis rs6586163 0.527 rs3824730 chr10:90752128 A/T cg03111039 chr10:90751583 FAS;ACTA2 0.83 12.63 0.57 4.48e-30 Chronic lymphocytic leukemia; CRC cis rs950169 1.000 rs1911155 chr15:84787635 A/G cg17507749 chr15:85114479 UBE2QP1 0.76 11.75 0.54 7.52e-27 Schizophrenia; CRC cis rs9296092 0.538 rs115770720 chr6:33517032 A/T cg13560919 chr6:33536144 NA -0.42 -5.94 -0.31 7.09e-9 Age at smoking initiation in chronic obstructive pulmonary disease; CRC cis rs2976388 0.609 rs2717550 chr8:143787808 T/A cg24046110 chr8:143859143 LYNX1 0.49 8.61 0.43 3.1e-16 Urinary tract infection frequency; CRC cis rs7412746 0.658 rs12067685 chr1:150952917 T/C cg17724175 chr1:150552817 MCL1 0.47 6.93 0.36 2.28e-11 Melanoma; CRC cis rs11583043 0.957 rs6577223 chr1:101499750 G/T cg16556008 chr1:101360663 SLC30A7;EXTL2 0.46 5.89 0.31 9.3e-9 Ulcerative colitis;Inflammatory bowel disease; CRC cis rs12760731 0.720 rs12048790 chr1:178407906 T/C cg00404053 chr1:178313656 RASAL2 0.95 9.79 0.47 5.03e-20 Obesity-related traits; CRC cis rs9522267 0.535 rs11069899 chr13:112231553 T/C cg10483660 chr13:112241077 NA -0.46 -8.59 -0.43 3.67e-16 Hepatitis; CRC cis rs2742417 0.624 rs2673068 chr3:45768981 G/A cg04837898 chr3:45731254 SACM1L -0.49 -8.02 -0.4 1.81e-14 Response to anti-depressant treatment in major depressive disorder; CRC cis rs3858526 0.584 rs10769266 chr11:5858460 C/T cg02574844 chr11:5959923 NA -0.49 -7.03 -0.36 1.2e-11 DNA methylation (variation); CRC cis rs2836950 0.565 rs7278297 chr21:40625752 A/C cg11890956 chr21:40555474 PSMG1 -0.61 -8.79 -0.44 8.73e-17 Menarche (age at onset); CRC cis rs7408868 1.000 rs6512018 chr19:15282138 T/C cg14696996 chr19:15285081 NOTCH3 0.96 8.93 0.44 2.98e-17 Pulse pressure; CRC cis rs11628318 0.617 rs11626481 chr14:103086356 A/G cg23461800 chr14:103021989 NA -0.67 -7.68 -0.39 1.87e-13 Platelet count; CRC cis rs9469578 1.000 rs6942022 chr6:33710284 C/T cg18708504 chr6:33715942 IP6K3 0.63 7.23 0.37 3.44e-12 Phosphorus levels; CRC cis rs6088580 0.634 rs6088502 chr20:33037644 A/T cg08999081 chr20:33150536 PIGU 0.61 11.35 0.53 1.99e-25 Glomerular filtration rate (creatinine); CRC cis rs929354 0.742 rs886677 chr7:157003782 T/A cg05182265 chr7:156933206 UBE3C -0.76 -14.49 -0.62 3.8e-37 Body mass index; CRC cis rs1568889 0.838 rs7127069 chr11:28325412 A/G cg06544937 chr11:28130018 METT5D1;KIF18A 0.92 15.62 0.65 1.5e-41 Bipolar disorder; CRC cis rs968567 0.705 rs174572 chr11:61598288 C/T cg06781209 chr11:61594997 FADS2 -0.57 -8.02 -0.4 1.84e-14 Blood metabolite levels;Rheumatoid arthritis;Vitiligo;Glycerophospholipid levels; CRC cis rs9486719 1.000 rs2472880 chr6:96860130 G/A cg06623918 chr6:96969491 KIAA0776 0.8 9.14 0.45 6.82e-18 Migraine;Coronary artery disease; CRC cis rs372883 0.554 rs10154065 chr21:30749480 G/C cg24692254 chr21:30365293 RNF160 0.63 9.62 0.47 1.8e-19 Pancreatic cancer; CRC cis rs17270561 0.609 rs9379786 chr6:25730255 T/C cg16482183 chr6:26056742 HIST1H1C 0.83 10.58 0.5 1.07e-22 Iron status biomarkers; CRC cis rs10751667 0.666 rs7395182 chr11:927553 A/C ch.11.42038R chr11:967971 AP2A2 0.6 10.22 0.49 1.74e-21 Alzheimer's disease (late onset); CRC cis rs4713118 0.786 rs200503 chr6:27785882 A/G cg25164649 chr6:28176230 NA 0.58 7.24 0.37 3.2e-12 Parkinson's disease; CRC cis rs2842992 0.789 rs9365093 chr6:160175819 C/G cg11366901 chr6:160182831 ACAT2 0.96 13.93 0.61 5.31e-35 Age-related macular degeneration (geographic atrophy); CRC cis rs9443645 0.901 rs4415132 chr6:79554107 T/C cg05283184 chr6:79620031 NA -0.57 -9.17 -0.45 5.23e-18 Intelligence (multi-trait analysis); CRC cis rs9462027 0.628 rs2814942 chr6:34644261 G/A cg07306190 chr6:34760872 UHRF1BP1 -0.35 -6.26 -0.33 1.17e-9 Systemic lupus erythematosus; CRC cis rs9858542 0.953 rs1873625 chr3:49666964 C/A cg00383909 chr3:49044727 WDR6 0.48 5.92 0.31 7.98e-9 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs11864453 0.963 rs7185215 chr16:72034864 T/C cg01557791 chr16:72042693 DHODH -0.53 -7.37 -0.38 1.41e-12 Fibrinogen levels; CRC cis rs375066 0.967 rs8104290 chr19:44367338 A/G cg12072164 chr19:44306565 LYPD5 0.37 5.61 0.3 4.31e-8 Breast cancer; CRC cis rs62244186 0.659 rs56231820 chr3:44530329 C/T cg11003573 chr3:44754125 ZNF502 -0.35 -5.89 -0.31 9.62e-9 Depressive symptoms; CRC cis rs10870270 0.956 rs67378218 chr10:133752420 A/C cg08754478 chr10:133766260 PPP2R2D -0.68 -9.86 -0.48 2.9e-20 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; CRC cis rs10504229 0.769 rs17215649 chr8:58152791 A/G cg11062466 chr8:58055876 NA 0.45 6.11 0.32 2.74e-9 Developmental language disorder (linguistic errors); CRC cis rs1448094 0.512 rs6539933 chr12:86247611 T/C cg02569458 chr12:86230093 RASSF9 0.43 7.4 0.38 1.17e-12 Major depressive disorder; CRC cis rs3736485 0.934 rs8036609 chr15:51861426 C/G cg08986416 chr15:51914746 DMXL2 -0.45 -6.56 -0.34 2.12e-10 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs10504229 1.000 rs61998258 chr8:58192284 T/C cg05313129 chr8:58192883 C8orf71 -0.47 -6.99 -0.36 1.49e-11 Developmental language disorder (linguistic errors); CRC cis rs6809651 0.524 rs1356292 chr3:185824903 C/T cg00760338 chr3:185826511 ETV5 0.74 9.19 0.45 4.55e-18 Body mass index in physically active individuals;Glomerular filtration rate (creatinine);Body mass index (joint analysis main effects and physical activity interaction);Body mass index;Body mass index in physically inactive individuals; CRC cis rs1451375 0.583 rs3807555 chr7:50610569 A/G cg18232548 chr7:50535776 DDC 0.46 6.16 0.32 2.1e-9 Malaria; CRC cis rs12802244 1 rs12802244 chr11:47932666 G/A cg18512352 chr11:47633146 NA -0.46 -8.61 -0.43 3e-16 Neuroticism; CRC cis rs2274471 0.645 rs10815163 chr9:5122932 A/G cg03390472 chr9:5043263 JAK2 -0.51 -5.9 -0.31 8.91e-9 Crohn's disease; CRC cis rs7951870 0.645 rs57804402 chr11:46729872 T/C cg19486271 chr11:47235900 DDB2 0.45 7.06 0.36 1.02e-11 Schizophrenia; CRC cis rs34172651 0.517 rs874484 chr16:24803242 T/C cg02428538 chr16:24856791 SLC5A11 -0.61 -6.88 -0.35 3.04e-11 Intelligence (multi-trait analysis); CRC cis rs2249625 0.545 rs2496487 chr6:72875226 G/C cg18830697 chr6:72922368 RIMS1 -0.39 -7.83 -0.4 6.67e-14 Acute urticaria and angioedema (non-steroidal anti-inflammatory drug-induced); CRC cis rs7666738 1.000 rs13106934 chr4:99028685 C/T cg03676636 chr4:99064102 C4orf37 0.25 6.92 0.36 2.44e-11 Colonoscopy-negative controls vs population controls; CRC cis rs11971779 0.680 rs7805824 chr7:139111169 C/G cg07862535 chr7:139043722 LUC7L2 -0.58 -7.53 -0.38 5.03e-13 Diisocyanate-induced asthma; CRC cis rs709400 0.628 rs7155014 chr14:103863970 C/G cg12935359 chr14:103987150 CKB -0.49 -7.48 -0.38 6.67e-13 Body mass index; CRC cis rs11724804 0.532 rs62297079 chr4:879977 G/A cg20916646 chr4:852691 GAK 0.6 8.59 0.43 3.65e-16 Primary biliary cholangitis;Limited cutaneous systemic scleroderma; CRC cis rs9419702 0.568 rs7920966 chr10:133555185 G/T cg04492858 chr10:133558786 NA 0.36 5.88 0.31 1e-8 Survival in rectal cancer; CRC cis rs6570726 0.935 rs436212 chr6:145849400 G/A cg05347473 chr6:146136440 FBXO30 0.38 6.09 0.32 3.19e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs9287719 0.967 rs6748036 chr2:10717489 C/T cg00105475 chr2:10696890 NA 0.46 7.41 0.38 1.08e-12 Prostate cancer; CRC cis rs172166 0.694 rs203893 chr6:28062066 C/A cg23161317 chr6:28129485 ZNF389 0.46 6.45 0.33 4.09e-10 Cardiac Troponin-T levels; CRC trans rs4843747 0.671 rs9933794 chr16:88116981 T/C cg26811252 chr16:29126840 RRN3P2 0.63 8.57 0.43 4.23e-16 Menopause (age at onset); CRC trans rs1823549 1.000 rs7528732 chr1:103200189 A/G cg08492707 chr21:34696952 IFNAR1 0.71 6.05 0.32 4.01e-9 Systemic juvenile idiopathic arthritis; CRC cis rs7208859 0.673 rs11652409 chr17:29182707 T/A cg13385521 chr17:29058706 SUZ12P 0.65 7.73 0.39 1.31e-13 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs524281 0.731 rs476551 chr11:66006323 G/C cg16950941 chr11:66035639 RAB1B -0.68 -7.95 -0.4 3.01e-14 Electroencephalogram traits; CRC cis rs1552244 0.882 rs35056669 chr3:10014171 C/T cg18598329 chr3:10140678 FANCD2;C3orf24 -0.82 -10.77 -0.51 2.31e-23 Alzheimer's disease; CRC cis rs2952156 0.920 rs12940986 chr17:37836581 A/G cg07936489 chr17:37558343 FBXL20 0.44 6.31 0.33 9.12e-10 Asthma; CRC cis rs9929218 0.817 rs3118228 chr16:68710737 T/G cg02972257 chr16:68554789 NA 0.53 6.58 0.34 1.89e-10 Colorectal cancer; CRC cis rs1008375 1.000 rs7436403 chr4:17692685 T/G cg16339924 chr4:17578868 LAP3 -0.43 -5.66 -0.3 3.29e-8 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs72781680 0.898 rs72780123 chr2:23996009 G/A cg08917208 chr2:24149416 ATAD2B 0.86 8.35 0.42 1.86e-15 Lymphocyte counts; CRC cis rs2898857 0.524 rs2072153 chr17:47390014 C/G cg08112188 chr17:47440006 ZNF652 -0.44 -5.92 -0.31 8.17e-9 Cancer; CRC cis rs2404602 0.967 rs12148805 chr15:76800659 G/A cg22467129 chr15:76604101 ETFA -0.37 -6.25 -0.33 1.24e-9 Blood metabolite levels; CRC cis rs1559088 0.600 rs58173463 chr19:33596749 C/T cg27124370 chr19:33622961 WDR88 0.46 6.84 0.35 3.9e-11 Bone ultrasound measurement (broadband ultrasound attenuation); CRC cis rs12760731 0.623 rs7547158 chr1:178309399 A/G cg00404053 chr1:178313656 RASAL2 0.73 9.16 0.45 5.79e-18 Obesity-related traits; CRC cis rs2228479 0.867 rs57492102 chr16:89975572 A/G cg06558623 chr16:89946397 TCF25 0.89 9.76 0.47 6.25e-20 Skin colour saturation; CRC cis rs1832871 0.711 rs9459887 chr6:158696479 C/T cg07165851 chr6:158734300 TULP4 0.6 7.59 0.39 3.38e-13 Height; CRC cis rs17376456 0.757 rs10066431 chr5:93198204 A/G cg09848695 chr5:92956644 FAM172A;MIR2277 0.71 6.31 0.33 8.84e-10 Diabetic retinopathy; CRC cis rs514406 0.607 rs6696940 chr1:53203427 C/T cg24675658 chr1:53192096 ZYG11B 0.68 10.46 0.5 2.76e-22 Monocyte count; CRC cis rs7932354 0.550 rs10769208 chr11:46822240 T/C cg19486271 chr11:47235900 DDB2 -0.43 -6.47 -0.34 3.56e-10 Bone mineral density (hip);Bone mineral density; CRC cis rs1788820 0.917 rs1652349 chr18:21142734 A/T cg14672496 chr18:21087552 C18orf8 0.53 9.3 0.46 2.07e-18 Body mass index; CRC cis rs3008870 0.755 rs11208974 chr1:67398119 A/T cg08660285 chr1:67390436 MIER1;WDR78 0.55 7.72 0.39 1.37e-13 Lymphocyte percentage of white cells; CRC cis rs6598955 0.640 rs1577507 chr1:26547179 C/T cg04990556 chr1:26633338 UBXN11 -0.79 -13.27 -0.59 1.75e-32 Obesity-related traits; CRC cis rs2153535 0.580 rs7767780 chr6:8453462 A/G cg07606381 chr6:8435919 SLC35B3 0.67 10.81 0.51 1.63e-23 Motion sickness; CRC cis rs9911578 1.000 rs6503887 chr17:56993320 T/C cg12560992 chr17:57184187 TRIM37 0.91 16.91 0.68 1.27e-46 Intelligence (multi-trait analysis); CRC cis rs10504229 0.906 rs59336968 chr8:58176857 T/C cg22535103 chr8:58192502 C8orf71 -0.82 -12.27 -0.56 9.63e-29 Developmental language disorder (linguistic errors); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg19737787 chr13:28492265 NA 0.41 7.19 0.37 4.49e-12 Liver disease severity in Alagille syndrome; CRC cis rs8062405 0.721 rs151181 chr16:28490517 A/G cg16576597 chr16:28551801 NUPR1 0.44 6.19 0.32 1.75e-9 Cognitive ability (multi-trait analysis);Cognitive ability; CRC cis rs7616330 0.775 rs6794619 chr3:71039895 A/G cg01511742 chr3:71112437 FOXP1 -0.56 -6.53 -0.34 2.52e-10 QT interval; CRC cis rs8141529 0.636 rs5762799 chr22:29187380 G/T cg02153584 chr22:29168773 CCDC117 0.48 6.13 0.32 2.58e-9 Lymphocyte counts; CRC cis rs9611565 0.802 rs73176694 chr22:41786788 C/T cg03806693 chr22:41940476 POLR3H -1.01 -12.7 -0.57 2.36e-30 Vitiligo; CRC cis rs9303401 0.659 rs34878689 chr17:56694330 G/A cg10487724 chr17:56770010 TEX14;RAD51C 0.8 9.19 0.45 4.41e-18 Cognitive test performance; CRC cis rs35883536 0.609 rs1577513 chr1:101044402 C/A cg06223162 chr1:101003688 GPR88 0.35 6.42 0.33 4.76e-10 Monocyte count; CRC cis rs9807989 0.773 rs5010059 chr2:102968826 C/G cg03938978 chr2:103052716 IL18RAP 0.36 5.92 0.31 7.92e-9 Asthma; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg15064598 chr1:28879563 TRNAU1AP 0.46 6.53 0.34 2.55e-10 Anxiety disorder; CRC cis rs6831352 0.918 rs29001209 chr4:100052340 C/A cg13256891 chr4:100009986 ADH5 -0.66 -8.89 -0.44 4.04e-17 Alcohol dependence; CRC cis rs2836974 0.897 rs2836928 chr21:40543320 C/T cg11644478 chr21:40555479 PSMG1 0.73 10.7 0.51 3.89e-23 Cognitive function; CRC cis rs116095464 0.558 rs6882584 chr5:223411 A/C cg22496380 chr5:211416 CCDC127 -0.83 -9.55 -0.47 3.03e-19 Breast cancer; CRC cis rs514406 0.679 rs61768344 chr1:53229274 G/A cg27535305 chr1:53392650 SCP2 0.47 8.52 0.43 5.79e-16 Monocyte count; CRC cis rs6860806 0.531 rs2631359 chr5:131707892 C/T cg24060327 chr5:131705240 SLC22A5 0.53 8.01 0.4 2.02e-14 Breast cancer; CRC cis rs7552404 0.961 rs448710 chr1:76116554 T/C cg03433033 chr1:76189801 ACADM -0.82 -11.32 -0.53 2.69e-25 Blood metabolite levels;Acylcarnitine levels; CRC cis rs28386778 0.897 rs11654841 chr17:61838259 C/T cg25654072 chr17:61904446 PSMC5;FTSJ3 0.7 10.83 0.51 1.44e-23 Prudent dietary pattern; CRC cis rs7639513 0.767 rs6784168 chr3:12702847 T/G cg23032965 chr3:12705835 RAF1 0.64 9.83 0.48 3.71e-20 Itch intensity from mosquito bite; CRC cis rs11758351 0.866 rs2022448 chr6:26207928 C/T cg01420254 chr6:26195488 NA 0.7 8.74 0.43 1.2e-16 Gout;Renal underexcretion gout; CRC trans rs7395662 1.000 rs11039745 chr11:48463811 G/C cg21153622 chr11:89784906 NA -0.51 -8.05 -0.41 1.48e-14 HDL cholesterol; CRC cis rs12594515 0.967 rs8039088 chr15:45990178 T/C cg19682013 chr15:45996608 NA 0.32 6.7 0.35 9.09e-11 Waist circumference;Weight; CRC cis rs1008375 0.966 rs2191504 chr4:17675592 C/G cg04450456 chr4:17643702 FAM184B 0.39 6.22 0.32 1.53e-9 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs10504229 0.679 rs11783963 chr8:58130496 T/A cg02290350 chr8:58132656 NA -0.58 -8.16 -0.41 7.29e-15 Developmental language disorder (linguistic errors); CRC trans rs4263408 0.934 rs9683743 chr4:39703194 A/C cg01202521 chr16:1360231 UBE2I -0.42 -6.19 -0.32 1.8e-9 Plasma amyloid beta peptide concentrations (ABx-40); CRC cis rs875971 0.862 rs2420611 chr7:65999320 A/G cg18252515 chr7:66147081 NA -0.43 -6.21 -0.32 1.56e-9 Aortic root size; CRC cis rs9910055 0.530 rs11656758 chr17:42301541 A/G cg19774624 chr17:42201019 HDAC5 -0.39 -5.83 -0.31 1.33e-8 Total body bone mineral density; CRC cis rs6860806 0.507 rs273912 chr5:131661349 A/C cg20512303 chr5:131592959 PDLIM4 -0.38 -6.59 -0.34 1.71e-10 Breast cancer; CRC cis rs9311474 0.502 rs4687624 chr3:52563572 C/T cg07507251 chr3:52567010 NT5DC2 0.49 7.33 0.37 1.77e-12 Electroencephalogram traits; CRC trans rs459571 0.920 rs417142 chr9:136891370 G/T cg09836344 chr4:1243392 C4orf42;CTBP1 -0.82 -11.47 -0.53 7.35e-26 Platelet distribution width; CRC cis rs9486719 1.000 rs11757063 chr6:96884886 C/T cg06623918 chr6:96969491 KIAA0776 -0.8 -9.57 -0.47 2.61e-19 Migraine;Coronary artery disease; CRC cis rs12701220 0.655 rs10215292 chr7:1135263 A/G cg26769984 chr7:1090371 C7orf50 0.51 6.92 0.36 2.31e-11 Bronchopulmonary dysplasia; CRC cis rs875971 0.862 rs880166 chr7:65670762 T/C cg00343986 chr7:65444356 GUSB -0.42 -6.01 -0.31 4.92e-9 Aortic root size; CRC cis rs3806843 0.735 rs6849 chr5:140086191 G/T cg26395211 chr5:140044315 WDR55 0.38 5.63 0.3 3.92e-8 Depressive symptoms (multi-trait analysis); CRC cis rs12188164 0.543 rs890972 chr5:462465 C/A cg14122633 chr5:456516 EXOC3 -0.4 -7.16 -0.37 5.37e-12 Cystic fibrosis severity; CRC cis rs57221529 0.766 rs17497684 chr5:558307 T/C cg14541582 chr5:601475 NA -0.32 -6.36 -0.33 6.83e-10 Lung disease severity in cystic fibrosis; CRC cis rs4665809 0.567 rs12999875 chr2:26414847 A/C cg26119090 chr2:26468346 HADHA;HADHB 1.05 15.02 0.64 3.46e-39 Gut microbiome composition (summer); CRC cis rs1799949 1.000 rs8176220 chr17:41222462 A/G cg05368731 chr17:41323189 NBR1 0.68 10.22 0.49 1.81e-21 Menopause (age at onset); CRC cis rs2549003 1.000 rs9282762 chr5:131822055 T/C cg02551604 chr5:131831745 NA -0.54 -8.34 -0.42 2e-15 Asthma (sex interaction); CRC cis rs11123610 0.520 rs12996655 chr2:3720900 G/A cg10645314 chr2:3704589 ALLC -0.54 -6.39 -0.33 5.78e-10 Response to inhaled corticosteroid treatment in asthma (change in FEV1); CRC cis rs9911578 1.000 rs12938772 chr17:56776320 T/C cg05425664 chr17:57184151 TRIM37 -0.49 -7.63 -0.39 2.59e-13 Intelligence (multi-trait analysis); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg24701985 chr7:149535383 ZNF862 0.46 6.55 0.34 2.28e-10 Response to antipsychotic treatment; CRC cis rs798554 0.679 rs1636249 chr7:2884283 T/G cg13628971 chr7:2884303 GNA12 0.6 8.63 0.43 2.73e-16 Height; CRC cis rs5750830 0.621 rs743838 chr22:39824707 T/G cg11247378 chr22:39784982 NA -0.41 -7.25 -0.37 2.95e-12 Intelligence (multi-trait analysis); CRC trans rs875971 0.545 rs1796219 chr7:66110964 A/G cg02869306 chr7:64672164 INTS4L1 0.43 6.09 0.32 3.17e-9 Aortic root size; CRC cis rs1107366 1.000 rs1107366 chr3:125904165 A/G cg08481491 chr3:125900108 ALDH1L1 -0.32 -5.68 -0.3 2.92e-8 Metabolite levels; CRC cis rs11628318 0.515 rs1190343 chr14:103100348 G/A cg12046867 chr14:103022105 NA -0.41 -5.62 -0.3 4.02e-8 Platelet count; CRC cis rs2075371 0.897 rs1643033 chr7:134004662 T/C cg02659138 chr7:134003124 SLC35B4 0.42 7.36 0.38 1.47e-12 Mean platelet volume; CRC cis rs875971 1.000 rs778706 chr7:65860424 A/G cg12463550 chr7:65579703 CRCP 0.48 6.96 0.36 1.89e-11 Aortic root size; CRC cis rs17767392 0.881 rs12880611 chr14:71923349 G/A cg13720639 chr14:72061746 SIPA1L1 -0.56 -7.17 -0.37 5.11e-12 Mitral valve prolapse; CRC cis rs6963495 0.818 rs56165465 chr7:105180384 C/T cg02135003 chr7:105160482 PUS7 -0.73 -10.52 -0.5 1.68e-22 Bipolar disorder (body mass index interaction); CRC cis rs2797685 1.000 rs707467 chr1:7861684 A/C cg04725166 chr1:7887271 PER3 -0.49 -6.21 -0.32 1.62e-9 Crohn's disease; CRC cis rs2153535 0.580 rs6597335 chr6:8527714 T/C cg21535247 chr6:8435926 SLC35B3 0.48 7.35 0.38 1.6e-12 Motion sickness; CRC cis rs4731207 0.596 rs7806530 chr7:124659884 C/T cg23710748 chr7:124431027 NA 0.37 5.94 0.31 7.28e-9 Cutaneous malignant melanoma; CRC cis rs394563 0.601 rs382720 chr6:149795261 C/T cg11245181 chr6:149772854 ZC3H12D 0.42 6.84 0.35 3.78e-11 Dupuytren's disease; CRC cis rs7107174 1.000 rs7119933 chr11:78049750 A/C cg02023728 chr11:77925099 USP35 0.48 8.59 0.43 3.44e-16 Testicular germ cell tumor; CRC cis rs67614146 1 rs67614146 chr6:87821827 AC/A cg12350822 chr6:88032061 C6orf162;GJB7 -0.47 -9.36 -0.46 1.29e-18 Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC trans rs2797160 1.000 rs1935774 chr6:125996661 A/G cg05039488 chr6:79577232 IRAK1BP1 0.5 7.28 0.37 2.48e-12 Endometrial cancer; CRC cis rs17152411 1.000 rs10901843 chr10:126638020 A/G cg07906193 chr10:126599966 NA 0.59 6.77 0.35 6.03e-11 Height; CRC cis rs1348850 0.567 rs7605609 chr2:178534942 C/G cg02961200 chr2:178257176 LOC100130691;AGPS 0.54 7.52 0.38 5.24e-13 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs1800469 1.000 rs2241714 chr19:41869392 C/T cg08477640 chr19:41863820 B9D2 -0.58 -7.99 -0.4 2.32e-14 Colorectal cancer; CRC cis rs704795 0.867 rs7566052 chr2:27628635 A/G cg24768116 chr2:27665128 KRTCAP3 -0.36 -8.07 -0.41 1.38e-14 Menopause (age at onset); CRC cis rs2762353 0.595 rs12207313 chr6:25741027 G/C cg12310025 chr6:25882481 NA 0.73 10.54 0.5 1.39e-22 Blood metabolite levels; CRC cis rs853679 0.517 rs9393886 chr6:28050039 T/G cg21251018 chr6:28226885 NKAPL 0.47 6.23 0.33 1.39e-9 Depression; CRC trans rs1005277 0.579 rs2474574 chr10:38387295 C/T cg23533926 chr12:111358616 MYL2 -0.52 -7.84 -0.4 6.17e-14 Extrinsic epigenetic age acceleration; CRC cis rs796364 0.950 rs188146 chr2:200750444 C/T cg12253985 chr2:200820533 C2orf60;C2orf47 0.61 6.84 0.35 3.79e-11 Schizophrenia; CRC cis rs1018836 0.663 rs56784954 chr8:91505094 C/T cg16814680 chr8:91681699 NA -0.69 -10.16 -0.49 2.94e-21 Ejection fraction in Tripanosoma cruzi seropositivity; CRC cis rs2565722 0.622 rs10945704 chr6:161290926 C/T cg03159191 chr6:161285451 NA -0.44 -5.98 -0.31 5.86e-9 Blood protein levels; CRC cis rs2075371 0.501 rs1643057 chr7:134027521 A/G cg20476274 chr7:133979776 SLC35B4 0.55 8.62 0.43 2.82e-16 Mean platelet volume; CRC cis rs883565 0.740 rs11708354 chr3:39115626 A/T cg01426195 chr3:39028469 NA -0.55 -8.8 -0.44 8.15e-17 Handedness; CRC cis rs7120118 0.517 rs3758674 chr11:47278938 T/C cg25783544 chr11:47291846 MADD 0.64 5.77 0.3 1.85e-8 HDL cholesterol; CRC cis rs10504229 1.000 rs73609764 chr8:58192971 G/A cg01721255 chr8:58191610 C8orf71 0.49 6.17 0.32 2e-9 Developmental language disorder (linguistic errors); CRC cis rs13118159 0.505 rs1250128 chr4:1257311 T/C cg20887711 chr4:1340912 KIAA1530 -0.73 -10.14 -0.49 3.33e-21 Longevity; CRC cis rs8141529 0.748 rs9620841 chr22:29290981 C/T cg15103426 chr22:29168792 CCDC117 0.51 7.1 0.36 7.57e-12 Lymphocyte counts; CRC cis rs561341 0.883 rs1034627 chr17:30219569 C/T cg12193833 chr17:30244370 NA -0.51 -6.58 -0.34 1.87e-10 Hip circumference adjusted for BMI; CRC cis rs1997103 1.000 rs2177804 chr7:55410302 G/A cg17469321 chr7:55412551 NA 0.72 11.28 0.53 3.48e-25 QRS interval (sulfonylurea treatment interaction); CRC cis rs3806843 0.735 rs801167 chr5:140081423 A/G cg19875535 chr5:140030758 IK 0.64 10.8 0.51 1.85e-23 Depressive symptoms (multi-trait analysis); CRC cis rs736801 0.521 rs2070729 chr5:131819921 G/T cg02551604 chr5:131831745 NA -0.41 -6.31 -0.33 8.82e-10 Breast cancer;Mosquito bite size; CRC cis rs2404602 1.000 rs2404602 chr15:77030792 A/G cg03037974 chr15:76606532 NA 0.6 10.17 0.49 2.53e-21 Blood metabolite levels; CRC cis rs3790645 1.000 rs282175 chr1:26895802 A/G cg17456097 chr1:26900765 RPS6KA1 0.45 6.71 0.35 8.6e-11 Glucose homeostasis traits; CRC cis rs4819052 0.851 rs2838840 chr21:46668494 A/G cg19498844 chr21:46707878 POFUT2;LOC642852 0.74 10.73 0.51 3.18e-23 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs516243 0.703 rs169538 chr1:10737045 T/C cg02903756 chr1:10750680 CASZ1 -0.48 -8.29 -0.42 2.84e-15 Migraine - clinic-based; CRC cis rs4713118 0.869 rs6902689 chr6:27709441 C/T cg21204522 chr6:27730016 NA -0.39 -5.61 -0.3 4.4e-8 Parkinson's disease; CRC cis rs853679 0.542 rs34131763 chr6:28075000 A/C cg15845792 chr6:28175446 NA 0.99 13.1 0.59 7.48e-32 Depression; CRC cis rs10504229 0.683 rs7817188 chr8:58129549 C/T cg21724239 chr8:58056113 NA 0.49 6.81 0.35 4.75e-11 Developmental language disorder (linguistic errors); CRC cis rs739401 0.611 rs494427 chr11:3048140 A/G cg25174290 chr11:3078921 CARS 0.46 7.04 0.36 1.15e-11 Longevity; CRC cis rs11148252 0.774 rs9536066 chr13:52983981 A/G cg02158880 chr13:53174818 NA 0.44 6.65 0.34 1.22e-10 Lewy body disease; CRC cis rs6546550 0.935 rs1056482 chr2:70108256 A/T cg02498382 chr2:70120550 SNRNP27 -0.39 -6.33 -0.33 8.18e-10 Prevalent atrial fibrillation; CRC cis rs6684514 1.000 rs10908499 chr1:156279176 G/C cg16558208 chr1:156270281 VHLL 0.56 8.8 0.44 7.83e-17 Mean corpuscular hemoglobin concentration;Glycated hemoglobin levels; CRC cis rs35110281 0.748 rs2838324 chr21:44999820 T/C cg04455712 chr21:45112962 RRP1B 0.43 8.3 0.42 2.7e-15 Mean corpuscular volume; CRC cis rs11098499 0.954 rs71629403 chr4:120372567 C/T cg24375607 chr4:120327624 NA 0.51 7.87 0.4 5.23e-14 Corneal astigmatism; CRC cis rs2243480 0.901 rs778730 chr7:65823325 T/A cg25985355 chr7:65971099 NA -0.54 -6.09 -0.32 3.09e-9 Diabetic kidney disease; CRC cis rs16852403 0.861 rs11583320 chr1:178042145 T/C cg00404053 chr1:178313656 RASAL2 0.48 6.03 0.32 4.46e-9 Childhood ear infection; CRC cis rs12545109 0.800 rs1530218 chr8:57407864 C/G cg09654669 chr8:57350985 NA -0.41 -5.71 -0.3 2.54e-8 Obesity-related traits; CRC cis rs2718058 0.519 rs2598047 chr7:37888488 G/T cg24998770 chr7:37888106 TXNDC3 0.37 6.07 0.32 3.51e-9 Alzheimer's disease (late onset); CRC cis rs9467711 0.651 rs72832596 chr6:25962951 C/A cg08501292 chr6:25962987 TRIM38 1.12 10.3 0.49 9.5e-22 Autism spectrum disorder or schizophrenia; CRC trans rs3942852 0.955 rs4752897 chr11:48136990 C/T cg15704280 chr7:45808275 SEPT13 -0.6 -7.21 -0.37 3.75e-12 Acute lymphoblastic leukemia (childhood); CRC cis rs1552244 0.882 rs17050699 chr3:10037167 G/A cg00166722 chr3:10149974 C3orf24 0.61 8.0 0.4 2.17e-14 Alzheimer's disease; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg07545535 chr7:76256818 POMZP3;LOC100133091 0.42 6.58 0.34 1.81e-10 Liver disease severity in Alagille syndrome; CRC trans rs4332037 0.539 rs11762636 chr7:2061111 C/A cg11693508 chr17:37793320 STARD3 0.61 7.23 0.37 3.36e-12 Bipolar disorder; CRC cis rs9914988 0.943 rs2242345 chr17:27185827 C/T cg20469991 chr17:27169893 C17orf63 0.58 7.02 0.36 1.26e-11 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs12024301 0.557 rs7530521 chr1:183610653 T/G cg11505048 chr1:183622726 RGL1;APOBEC4 0.81 7.0 0.36 1.42e-11 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs13191362 0.507 rs2849525 chr6:163126652 A/C cg06582575 chr6:163149167 PACRG;PARK2 -0.58 -8.97 -0.44 2.32e-17 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs7618915 0.547 rs68021750 chr3:52624769 G/A cg15147215 chr3:52552868 STAB1 -0.62 -10.17 -0.49 2.64e-21 Bipolar disorder; CRC cis rs600806 0.813 rs4970759 chr1:109982213 C/A cg23032129 chr1:109941072 SORT1 -0.27 -5.63 -0.3 3.86e-8 Intelligence (multi-trait analysis); CRC cis rs8177253 0.965 rs8177245 chr3:133479230 A/G cg11941060 chr3:133502564 NA -0.58 -10.21 -0.49 1.98e-21 Iron status biomarkers; CRC cis rs7677751 0.848 rs4635872 chr4:55099041 C/A cg00691999 chr4:55094011 PDGFRA 0.41 5.76 0.3 1.89e-8 Corneal astigmatism; CRC cis rs2336384 1.000 rs6668386 chr1:12047233 T/C cg13216073 chr1:12042593 MFN2 0.49 7.18 0.37 4.79e-12 Platelet count; CRC cis rs2204008 0.837 rs2127955 chr12:37969194 A/G cg26384229 chr12:38710491 ALG10B 0.62 9.51 0.46 4.28e-19 Bladder cancer; CRC cis rs6665290 0.901 rs3795453 chr1:227205331 A/G cg10327440 chr1:227177885 CDC42BPA -0.96 -19.75 -0.74 8.53e-58 Myeloid white cell count; CRC cis rs2730245 0.527 rs62475645 chr7:158656825 G/A cg24397884 chr7:158709396 WDR60 0.93 11.25 0.53 4.59e-25 Height; CRC cis rs3796352 1.000 rs2336540 chr3:52974589 G/A cg07884673 chr3:53033167 SFMBT1 0.69 6.12 0.32 2.67e-9 Immune reponse to smallpox (secreted IL-2); CRC cis rs17666538 0.539 rs1703925 chr8:608279 A/G cg10396713 chr8:602097 NA 0.58 5.83 0.31 1.33e-8 IgG glycosylation; CRC cis rs4665809 0.590 rs1469523 chr2:26474631 T/A cg04944784 chr2:26401820 FAM59B 0.85 11.05 0.52 2.29e-24 Gut microbiome composition (summer); CRC cis rs910316 1.000 rs4903279 chr14:75546583 C/T cg11812906 chr14:75593930 NEK9 0.61 9.7 0.47 1e-19 Height; CRC cis rs8072100 0.512 rs9303533 chr17:45386540 A/G cg25173405 chr17:45401733 C17orf57 -0.57 -9.49 -0.46 4.72e-19 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs6860806 0.507 rs270601 chr5:131656997 T/C cg11843238 chr5:131593191 PDLIM4 0.44 7.41 0.38 1.09e-12 Breast cancer; CRC cis rs17666538 1.000 rs59631161 chr8:587808 G/T cg23958373 chr8:599963 NA -0.88 -7.74 -0.39 1.21e-13 IgG glycosylation; CRC cis rs2976388 0.967 rs2976393 chr8:143763618 C/G cg22687807 chr8:143858763 LYNX1 -0.37 -6.51 -0.34 2.88e-10 Urinary tract infection frequency; CRC cis rs883565 0.569 rs784511 chr3:39165548 A/G cg01426195 chr3:39028469 NA 0.42 6.99 0.36 1.56e-11 Handedness; CRC cis rs561341 0.883 rs72821942 chr17:30234460 C/T cg00745463 chr17:30367425 LRRC37B -0.72 -8.16 -0.41 7.1e-15 Hip circumference adjusted for BMI; CRC cis rs1816752 0.870 rs73469543 chr13:24998970 T/C cg02811702 chr13:24901961 NA 0.42 5.8 0.3 1.52e-8 Obesity-related traits; CRC cis rs4713118 0.621 rs4713132 chr6:28034035 A/G cg15845792 chr6:28175446 NA 0.92 12.48 0.57 1.64e-29 Parkinson's disease; CRC cis rs11148252 0.634 rs4941727 chr13:52721067 A/G cg00495681 chr13:53174319 NA -0.53 -7.98 -0.4 2.38e-14 Lewy body disease; CRC cis rs926938 0.505 rs360593 chr1:115472265 T/G cg12756093 chr1:115239321 AMPD1 0.48 7.09 0.36 8.36e-12 Autism; CRC cis rs67311347 1.000 rs4973898 chr3:40459532 A/G cg24209194 chr3:40518798 ZNF619 -0.44 -6.72 -0.35 8.12e-11 Renal cell carcinoma; CRC cis rs16975963 0.644 rs11666662 chr19:38154702 A/T cg15135657 chr19:38346511 NA 0.47 6.61 0.34 1.6e-10 Longevity; CRC cis rs9549328 0.520 rs36144023 chr13:113616592 T/C cg17524180 chr13:113633600 MCF2L 0.52 9.39 0.46 1e-18 Systolic blood pressure; CRC cis rs13108904 0.967 rs900028 chr4:1279162 A/T cg21620606 chr4:1342894 KIAA1530 0.35 5.76 0.3 1.96e-8 Obesity-related traits; CRC cis rs1538970 0.924 rs1006216 chr1:45909994 A/G cg05343316 chr1:45956843 TESK2 0.74 9.85 0.48 3.12e-20 Platelet count; CRC cis rs798766 1.000 rs1665362 chr4:1726367 T/A cg05874882 chr4:1763078 NA -0.39 -7.5 -0.38 6.03e-13 Bladder cancer;Urinary bladder cancer; CRC cis rs17345786 0.628 rs11718446 chr3:101552553 C/T cg12386194 chr3:101231763 SENP7 0.49 6.73 0.35 7.35e-11 Colonoscopy-negative controls vs population controls; CRC cis rs1030268 0.505 rs77112963 chr7:133259399 G/A cg10665199 chr7:133106180 EXOC4 0.66 7.88 0.4 4.73e-14 Intelligence (multi-trait analysis); CRC cis rs2290405 1.000 rs2290405 chr4:946974 A/G cg23939001 chr4:940644 TMEM175 -0.34 -6.48 -0.34 3.43e-10 Systemic sclerosis; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg21789898 chr13:29293245 SLC46A3 0.42 6.18 0.32 1.91e-9 Response to antipsychotic treatment; CRC cis rs1552244 0.572 rs58223482 chr3:10169746 G/C cg02579736 chr3:10068473 FANCD2;CIDECP 1.01 11.62 0.54 2.28e-26 Alzheimer's disease; CRC cis rs72945132 0.882 rs55905028 chr11:70127750 G/A cg00319359 chr11:70116639 PPFIA1 0.67 7.4 0.38 1.13e-12 Coronary artery disease; CRC cis rs7586879 0.752 rs11683748 chr2:25130434 C/T cg22495460 chr2:25135724 ADCY3 -0.88 -15.19 -0.64 7.68e-40 Body mass index; CRC trans rs11098499 0.863 rs28718422 chr4:120466304 C/A cg25214090 chr10:38739885 LOC399744 0.65 10.43 0.5 3.37e-22 Corneal astigmatism; CRC cis rs4332037 0.539 rs4470910 chr7:2071723 C/T cg21155852 chr7:2048760 MAD1L1 -0.5 -6.79 -0.35 5.39e-11 Bipolar disorder; CRC cis rs853679 0.513 rs9468296 chr6:28113730 A/G cg18032046 chr6:28092343 ZSCAN16 -0.51 -5.93 -0.31 7.47e-9 Depression; CRC cis rs62064224 0.791 rs2344977 chr17:30720573 C/G cg21839984 chr17:30846986 MYO1D -0.46 -7.35 -0.38 1.63e-12 Schizophrenia; CRC cis rs7107174 0.892 rs4945273 chr11:78096977 T/C cg02023728 chr11:77925099 USP35 0.47 7.25 0.37 2.92e-12 Testicular germ cell tumor; CRC trans rs7937682 0.961 rs7106104 chr11:111635655 T/C cg18187862 chr3:45730750 SACM1L -0.54 -7.63 -0.39 2.48e-13 Primary sclerosing cholangitis; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg25621096 chr1:151032116 CDC42SE1;MLLT11 0.48 8.9 0.44 3.94e-17 Liver disease severity in Alagille syndrome; CRC cis rs2976388 0.647 rs2082801 chr8:143786461 A/G cg22687807 chr8:143858763 LYNX1 0.49 8.79 0.44 8.77e-17 Urinary tract infection frequency; CRC cis rs8060686 0.641 rs78537727 chr16:68120606 A/G cg26727032 chr16:67993705 SLC12A4 -0.57 -6.59 -0.34 1.72e-10 HDL cholesterol;Metabolic syndrome; CRC cis rs6088580 0.634 rs4258875 chr20:32924895 C/A cg24642439 chr20:33292090 TP53INP2 -0.39 -6.66 -0.34 1.18e-10 Glomerular filtration rate (creatinine); CRC trans rs1814175 0.645 rs12364337 chr11:49942580 A/T cg15704280 chr7:45808275 SEPT13 -0.95 -16.82 -0.68 3.11e-46 Height; CRC cis rs35520189 0.591 rs6733001 chr2:113701447 G/A cg12858261 chr2:113808755 IL1F8 0.49 6.87 0.35 3.29e-11 Obstructive sleep apnea trait (apnea hypopnea index); CRC cis rs7312933 0.703 rs11181380 chr12:42616040 A/T cg19980929 chr12:42632907 YAF2 0.45 6.63 0.34 1.36e-10 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CRC cis rs8180040 0.966 rs6787422 chr3:47418509 G/T cg27129171 chr3:47204927 SETD2 0.52 8.11 0.41 9.97e-15 Colorectal cancer; CRC cis rs1448094 0.511 rs17279464 chr12:86164473 C/T cg25456477 chr12:86230367 RASSF9 0.38 6.51 0.34 2.82e-10 Major depressive disorder; CRC cis rs274567 0.501 rs2631368 chr5:131705297 T/G cg27615366 chr5:131592974 PDLIM4 -0.34 -6.1 -0.32 2.98e-9 Blood metabolite levels; CRC cis rs59043219 1 rs59043219 chr1:209970610 G/A cg21951975 chr1:209979733 IRF6 0.67 13.15 0.59 5.13e-32 Crohn's disease;Inflammatory bowel disease;Alzheimer's disease (APOE e4 interaction); CRC cis rs7666738 0.830 rs35938349 chr4:98974998 T/C cg17366294 chr4:99064904 C4orf37 0.44 7.44 0.38 8.98e-13 Colonoscopy-negative controls vs population controls; CRC cis rs4481887 0.927 rs4405158 chr1:248490647 A/C cg00666640 chr1:248458726 OR2T12 0.49 8.29 0.42 3.01e-15 Common traits (Other); CRC trans rs7647973 0.626 rs2329021 chr3:49679072 G/A cg21659725 chr3:3221576 CRBN -0.67 -7.34 -0.38 1.72e-12 Menarche (age at onset); CRC cis rs2842992 0.724 rs4709368 chr6:160204127 C/T cg16489826 chr6:160211363 TCP1;MRPL18 -0.56 -8.44 -0.42 1.03e-15 Age-related macular degeneration (geographic atrophy); CRC cis rs10504229 0.683 rs73605816 chr8:58117167 T/C cg24829409 chr8:58192753 C8orf71 -0.55 -8.03 -0.4 1.71e-14 Developmental language disorder (linguistic errors); CRC trans rs7395662 1.000 rs11039871 chr11:48626620 C/T cg21153622 chr11:89784906 NA 0.45 7.15 0.37 5.81e-12 HDL cholesterol; CRC cis rs12477438 0.520 rs4340581 chr2:99725025 C/T cg26064155 chr2:99771622 LIPT1;TSGA10 0.9 16.76 0.68 5.08e-46 Chronic sinus infection; CRC cis rs10504229 0.683 rs72649188 chr8:58108829 A/G cg21724239 chr8:58056113 NA 0.52 6.97 0.36 1.79e-11 Developmental language disorder (linguistic errors); CRC cis rs11622475 1.000 rs1187446 chr14:104409896 C/T cg20488157 chr14:104394430 TDRD9 0.68 9.85 0.48 3.03e-20 Bipolar disorder; CRC cis rs727505 1.000 rs3925331 chr7:124446137 C/G cg23710748 chr7:124431027 NA -0.65 -11.51 -0.54 5.57e-26 Lewy body disease; CRC cis rs875971 0.895 rs3857684 chr7:65938158 G/C cg00343986 chr7:65444356 GUSB 0.44 6.41 0.33 5.09e-10 Aortic root size; CRC cis rs2243480 1.000 rs2707831 chr7:66062511 G/A cg18252515 chr7:66147081 NA -1.27 -15.22 -0.64 5.52e-40 Diabetic kidney disease; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg22919916 chr22:19110091 DGCR2 0.37 6.17 0.32 1.97e-9 Liver disease severity in Alagille syndrome; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg15740437 chr3:122102855 FAM162A;CCDC58 0.42 5.97 0.31 6.15e-9 Intelligence (multi-trait analysis); CRC cis rs3733585 0.753 rs12500805 chr4:10017979 C/T cg11266682 chr4:10021025 SLC2A9 0.54 10.91 0.52 7.44e-24 Cleft plate (environmental tobacco smoke interaction); CRC cis rs7552404 0.961 rs211710 chr1:76109038 G/A cg10523679 chr1:76189770 ACADM -0.82 -11.02 -0.52 3.1e-24 Blood metabolite levels;Acylcarnitine levels; CRC cis rs2882667 0.690 rs160403 chr5:138058482 T/C cg09476006 chr5:138032270 NA 0.57 10.02 0.48 8.46e-21 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs7833986 1.000 rs61690651 chr8:57096661 C/T cg23139584 chr8:56987506 RPS20;SNORD54 0.53 6.81 0.35 4.56e-11 Height; CRC cis rs7119 0.717 rs7180732 chr15:77829921 G/A cg10437265 chr15:77819839 NA 0.69 12.38 0.56 3.8e-29 Type 2 diabetes; CRC cis rs7829975 0.522 rs6601689 chr8:8172283 C/T cg08975724 chr8:8085496 FLJ10661 0.45 6.74 0.35 7.22e-11 Mood instability; CRC cis rs4889855 0.505 rs12952775 chr17:78607820 A/G cg16591659 chr17:78472290 NA -0.43 -6.3 -0.33 9.56e-10 Fractional excretion of uric acid; CRC trans rs10504229 1.000 rs55944282 chr8:58180821 A/G cg04077850 chr5:125800366 GRAMD3 0.37 6.27 0.33 1.15e-9 Developmental language disorder (linguistic errors); CRC cis rs6500602 0.627 rs11639998 chr16:4527109 T/C cg14951292 chr16:4525986 HMOX2;NMRAL1 0.75 10.53 0.5 1.58e-22 Schizophrenia; CRC cis rs908922 0.676 rs4240884 chr1:152529792 C/T cg23254163 chr1:152506842 NA -0.45 -9.13 -0.45 6.92e-18 Hair morphology; CRC cis rs8038465 0.615 rs11072430 chr15:73981701 A/G cg15420318 chr15:73925796 NPTN -0.37 -5.76 -0.3 1.98e-8 Liver enzyme levels (gamma-glutamyl transferase); CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg16823105 chr6:97372572 KLHL32 -0.52 -6.39 -0.33 5.59e-10 Diisocyanate-induced asthma; CRC cis rs1552244 1.000 rs7615764 chr3:10082592 C/T cg16606324 chr3:10149918 C3orf24 0.73 9.77 0.47 5.73e-20 Alzheimer's disease; CRC cis rs875971 0.862 rs2420173 chr7:65645399 A/T cg12463550 chr7:65579703 CRCP -0.54 -7.69 -0.39 1.7e-13 Aortic root size; CRC cis rs11122272 0.735 rs2790889 chr1:231520240 C/A cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.54 -8.09 -0.41 1.18e-14 Hemoglobin concentration; CRC cis rs932287 0.545 rs1960181 chr11:9046767 A/C cg14711859 chr11:8959438 ASCL3 -0.47 -7.44 -0.38 9.02e-13 Colonoscopy-negative controls vs population controls; CRC cis rs13108904 0.935 rs1732102 chr4:1277924 T/C cg16405210 chr4:1374714 KIAA1530 0.43 6.31 0.33 8.86e-10 Obesity-related traits; CRC cis rs7811142 0.830 rs6945952 chr7:99981775 A/G cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.61 7.88 0.4 4.81e-14 Platelet count; CRC cis rs847577 0.722 rs1013887 chr7:97709345 G/T cg24562669 chr7:97807699 LMTK2 0.73 16.23 0.67 6.44e-44 Breast cancer; CRC cis rs2404602 0.618 rs12442266 chr15:76567142 T/C cg03037974 chr15:76606532 NA 0.84 17.33 0.69 2.92e-48 Blood metabolite levels; CRC cis rs763121 0.785 rs5750646 chr22:39013830 T/C cg06544989 chr22:39130855 UNC84B 0.46 7.37 0.38 1.39e-12 Menopause (age at onset); CRC cis rs4654899 0.743 rs61778528 chr1:21059837 C/T cg02927042 chr1:21476669 EIF4G3 -0.44 -6.54 -0.34 2.33e-10 Superior frontal gyrus grey matter volume; CRC cis rs10504229 0.683 rs7820302 chr8:58142502 C/T cg02290350 chr8:58132656 NA -0.55 -8.04 -0.41 1.69e-14 Developmental language disorder (linguistic errors); CRC cis rs9910055 0.821 rs4473241 chr17:42281282 G/T cg16434002 chr17:42200994 HDAC5 -0.49 -7.17 -0.37 5.04e-12 Total body bone mineral density; CRC cis rs8180040 0.654 rs1466740 chr3:47245883 C/T cg02527881 chr3:46936655 PTH1R 0.35 6.17 0.32 2.04e-9 Colorectal cancer; CRC cis rs921968 0.565 rs1541777 chr2:219587291 A/G cg02176678 chr2:219576539 TTLL4 -0.39 -6.3 -0.33 9.48e-10 Mean corpuscular hemoglobin concentration; CRC cis rs10504229 0.775 rs17805146 chr8:58161484 G/A cg02725872 chr8:58115012 NA -0.6 -9.17 -0.45 5.2e-18 Developmental language disorder (linguistic errors); CRC cis rs10971721 0.643 rs72711741 chr9:33785111 A/G cg13495928 chr9:33750294 PRSS3 0.66 5.92 0.31 8.05e-9 Body mass index; CRC trans rs9929218 0.953 rs2902323 chr16:68736292 C/T cg04657470 chr2:198365150 HSPE1;HSPD1 -0.94 -12.55 -0.57 8.96e-30 Colorectal cancer; CRC cis rs6582630 0.574 rs12146797 chr12:38436499 T/C cg13010199 chr12:38710504 ALG10B 0.47 6.32 0.33 8.32e-10 Drug-induced liver injury (flucloxacillin); CRC cis rs6496667 0.865 rs7178103 chr15:90926799 C/T cg04176472 chr15:90893244 GABARAPL3 0.58 7.58 0.39 3.62e-13 Rheumatoid arthritis; CRC cis rs10463316 0.894 rs7710277 chr5:150767405 T/C cg03212797 chr5:150827313 SLC36A1 -0.5 -7.85 -0.4 6.1e-14 Metabolite levels (Pyroglutamine); CRC cis rs1448094 0.580 rs11615323 chr12:86282171 T/C cg19622623 chr12:86230825 RASSF9 -0.39 -5.82 -0.31 1.38e-8 Major depressive disorder; CRC cis rs1223397 0.651 rs2496149 chr6:13313893 A/G cg20827128 chr6:13274284 PHACTR1 0.36 5.62 0.3 4.07e-8 Blood pressure; CRC cis rs853679 0.542 rs34131763 chr6:28075000 A/C cg12172441 chr6:28176163 NA 0.62 7.33 0.37 1.76e-12 Depression; CRC cis rs780096 0.587 rs6760828 chr2:27579231 T/C cg21248554 chr2:27665150 KRTCAP3 -0.29 -6.67 -0.35 1.05e-10 Total body bone mineral density; CRC cis rs477895 0.568 rs34838337 chr11:63870892 T/C cg04317338 chr11:64019027 PLCB3 0.5 6.12 0.32 2.69e-9 Mean platelet volume; CRC cis rs3736485 0.966 rs2305708 chr15:51909960 C/T cg08986416 chr15:51914746 DMXL2 -0.45 -6.37 -0.33 6.54e-10 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs4713118 0.662 rs13218430 chr6:28029837 T/C cg15845792 chr6:28175446 NA 0.95 13.73 0.6 3.05e-34 Parkinson's disease; CRC cis rs9303401 0.646 rs7213269 chr17:57237796 C/T cg10487724 chr17:56770010 TEX14;RAD51C 0.43 6.36 0.33 6.68e-10 Cognitive test performance; CRC trans rs1005277 0.579 rs2504148 chr10:38400788 A/G cg11292332 chr7:45801988 SEPT13 -0.35 -6.23 -0.32 1.44e-9 Extrinsic epigenetic age acceleration; CRC cis rs6831352 0.589 rs2924584 chr4:99988208 A/G cg12011299 chr4:100065546 ADH4 0.57 13.44 0.6 4.15e-33 Alcohol dependence; CRC cis rs12681288 0.823 rs12681230 chr8:994422 G/A cg08648136 chr8:956695 NA 0.31 6.15 0.32 2.23e-9 Schizophrenia; CRC cis rs7591163 1.000 rs6436741 chr2:228714598 G/A cg21577049 chr2:228736449 WDR69 -0.47 -6.22 -0.32 1.5e-9 Blood pressure; CRC cis rs477895 0.713 rs11600867 chr11:63972052 T/A cg18225595 chr11:63971243 STIP1 0.59 7.6 0.39 3.15e-13 Mean platelet volume; CRC cis rs2739330 0.828 rs5760107 chr22:24252597 T/C cg10150615 chr22:24372951 LOC391322 -0.61 -9.32 -0.46 1.78e-18 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs7772486 0.790 rs1854900 chr6:146331382 G/A cg23711669 chr6:146136114 FBXO30 0.67 11.53 0.54 4.65e-26 Lobe attachment (rater-scored or self-reported); CRC cis rs11785400 0.793 rs35985277 chr8:143736137 C/T cg10596483 chr8:143751796 JRK 0.44 5.88 0.31 1.01e-8 Schizophrenia; CRC cis rs7811142 0.943 rs67196635 chr7:100025564 T/C cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.06 15.37 0.65 1.54e-40 Platelet count; CRC cis rs2243480 0.522 rs73150635 chr7:65972490 C/T cg18252515 chr7:66147081 NA -1.12 -10.05 -0.48 6.92e-21 Diabetic kidney disease; CRC cis rs910316 0.967 rs10142770 chr14:75525449 G/A cg11812906 chr14:75593930 NEK9 0.67 10.86 0.51 1.07e-23 Height; CRC cis rs853679 0.517 rs9393898 chr6:28130376 G/T cg25164649 chr6:28176230 NA 0.78 9.69 0.47 1.04e-19 Depression; CRC trans rs16846053 0.792 rs55893794 chr2:162418751 G/A cg27113153 chr11:123612418 ZNF202 -0.72 -6.15 -0.32 2.25e-9 Blood osmolality (transformed sodium); CRC trans rs7618501 1.000 rs9859153 chr3:49807085 G/T cg21582582 chr3:182698605 DCUN1D1 0.55 8.02 0.4 1.83e-14 Intelligence (multi-trait analysis); CRC cis rs17401966 1.000 rs1049887 chr1:10460485 T/C cg19773385 chr1:10388646 KIF1B -0.53 -6.83 -0.35 4.13e-11 Hepatocellular carcinoma; CRC cis rs4862750 0.872 rs9998172 chr4:187898773 T/C cg10295955 chr4:187884368 NA -1.07 -28.67 -0.85 1.81e-91 Lobe attachment (rater-scored or self-reported); CRC cis rs3617 0.572 rs2245538 chr3:52852060 T/C cg07507251 chr3:52567010 NT5DC2 0.4 6.09 0.32 3.07e-9 Red blood cell count;Autism spectrum disorder or schizophrenia; CRC cis rs28655083 0.673 rs2220233 chr16:77050294 A/G cg01753188 chr16:77233325 SYCE1L;MON1B -0.58 -6.85 -0.35 3.74e-11 Lobe attachment (rater-scored or self-reported); CRC cis rs4919694 1.000 rs76892505 chr10:104719290 G/A cg04362960 chr10:104952993 NT5C2 1.25 10.85 0.51 1.21e-23 Arsenic metabolism; CRC cis rs1218582 0.772 rs10908445 chr1:154849590 A/G cg03351412 chr1:154909251 PMVK -0.53 -8.47 -0.42 8.34e-16 Prostate cancer; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg04118154 chr1:45140072 C1orf228;TMEM53 0.45 6.28 0.33 1.06e-9 Response to antipsychotic treatment; CRC cis rs72781680 0.898 rs718139 chr2:23975911 G/A cg08917208 chr2:24149416 ATAD2B 1.03 9.71 0.47 9.22e-20 Lymphocyte counts; CRC trans rs8073060 0.586 rs7221203 chr17:34015532 T/C cg19694781 chr19:47549865 TMEM160 -1.07 -14.34 -0.62 1.5e-36 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; CRC trans rs113835537 0.627 rs4630309 chr11:66333072 A/C cg03753609 chr5:34656973 RAI14 0.61 6.67 0.35 1.09e-10 Airway imaging phenotypes; CRC cis rs17401966 0.931 rs3737155 chr1:10459779 G/A cg19773385 chr1:10388646 KIF1B -0.67 -10.51 -0.5 1.84e-22 Hepatocellular carcinoma; CRC cis rs1949733 0.666 rs3103070 chr4:8508825 A/G cg13073564 chr4:8508604 NA 0.45 6.59 0.34 1.73e-10 Response to antineoplastic agents; CRC cis rs7552404 0.924 rs1303169 chr1:76195041 T/C cg10523679 chr1:76189770 ACADM 0.78 11.93 0.55 1.63e-27 Blood metabolite levels;Acylcarnitine levels; CRC trans rs2727020 0.553 rs4980447 chr11:49591662 T/C cg11707556 chr5:10655725 ANKRD33B -0.49 -7.98 -0.4 2.52e-14 Coronary artery disease; CRC cis rs1707322 0.682 rs3014241 chr1:46087879 A/G cg06784218 chr1:46089804 CCDC17 -0.66 -12.09 -0.55 4.28e-28 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs601339 0.938 rs1696344 chr12:123183059 C/T cg22192744 chr12:123187474 GPR109A -0.4 -5.65 -0.3 3.46e-8 Adiponectin levels; CRC cis rs9487051 0.676 rs9398193 chr6:109593134 G/T cg12927641 chr6:109611667 NA -0.36 -6.44 -0.33 4.15e-10 Reticulocyte fraction of red cells; CRC cis rs815815 0.583 rs11125126 chr2:47395379 C/T cg27223769 chr2:47403360 CALM2 -0.51 -6.97 -0.36 1.7e-11 Dialysis-related mortality; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg17498102 chr14:71108199 TTC9 0.45 5.99 0.31 5.39e-9 Thyroid stimulating hormone; CRC cis rs6951245 1.000 rs79422648 chr7:1080241 T/C cg03188948 chr7:1209495 NA 0.63 6.54 0.34 2.29e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs13108904 0.901 rs7695691 chr4:1304632 A/G cg15763984 chr4:1342303 KIAA1530 0.34 5.7 0.3 2.68e-8 Obesity-related traits; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg14084056 chr12:48744539 ZNF641 0.35 6.11 0.32 2.87e-9 Liver disease severity in Alagille syndrome; CRC cis rs7666738 0.830 rs10031751 chr4:98939134 G/A cg05340658 chr4:99064831 C4orf37 0.6 9.35 0.46 1.41e-18 Colonoscopy-negative controls vs population controls; CRC cis rs4285028 0.747 rs11928871 chr3:121483388 G/C cg20356878 chr3:121714668 ILDR1 -0.51 -6.63 -0.34 1.39e-10 Multiple sclerosis; CRC cis rs9296092 0.517 rs7775914 chr6:33518110 T/C cg13560919 chr6:33536144 NA -0.43 -6.12 -0.32 2.68e-9 Age at smoking initiation in chronic obstructive pulmonary disease; CRC cis rs951366 0.789 rs823130 chr1:205714372 C/T cg14893161 chr1:205819251 PM20D1 0.83 13.09 0.59 8.54e-32 Menarche (age at onset); CRC cis rs55879323 1 rs55879323 chr1:152168740 C/T cg17718321 chr1:152188247 HRNR -0.35 -7.51 -0.38 5.57e-13 Inflammatory skin disease; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg15716185 chr18:60190644 ZCCHC2 0.56 8.59 0.43 3.51e-16 Response to antipsychotic treatment; CRC cis rs6952808 0.792 rs2056478 chr7:1953897 C/T cg02951883 chr7:2050386 MAD1L1 -0.69 -10.73 -0.51 3.16e-23 Bipolar disorder and schizophrenia; CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg15586420 chr15:90294517 MESP1 -0.5 -6.05 -0.32 3.96e-9 Diisocyanate-induced asthma; CRC cis rs736408 0.609 rs62255396 chr3:52782839 C/T cg08222913 chr3:52553049 STAB1 -0.34 -6.08 -0.32 3.35e-9 Bipolar disorder; CRC cis rs9902453 0.967 rs11080121 chr17:28528842 T/C cg26525008 chr17:28256777 EFCAB5;SSH2 0.6 9.22 0.45 3.63e-18 Coffee consumption (cups per day); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg22902534 chr3:183892754 AP2M1 0.38 6.07 0.32 3.59e-9 Liver disease severity in Alagille syndrome; CRC cis rs6502050 0.835 rs11658335 chr17:80084821 C/T cg09264619 chr17:80180166 NA 0.36 6.08 0.32 3.4e-9 Life satisfaction; CRC cis rs9649465 0.561 rs603060 chr7:123427568 A/G cg03229431 chr7:123269106 ASB15 -0.6 -9.66 -0.47 1.38e-19 Migraine; CRC cis rs4665809 0.941 rs1470096 chr2:26311482 T/C cg27170947 chr2:26402098 FAM59B -0.46 -5.89 -0.31 9.64e-9 Gut microbiome composition (summer); CRC cis rs870825 0.616 rs67641203 chr4:185623845 A/C cg04058563 chr4:185651563 MLF1IP 0.72 9.38 0.46 1.12e-18 Blood protein levels; CRC cis rs2075064 0.814 rs76496856 chr9:126780167 C/T cg14112217 chr9:126806003 NA 0.41 5.78 0.3 1.74e-8 Waist circumference; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg23956071 chr17:4710044 PLD2 0.39 6.63 0.34 1.39e-10 Liver disease severity in Alagille syndrome; CRC cis rs68170813 0.559 rs11769861 chr7:106979559 T/C cg02696742 chr7:106810147 HBP1 -0.58 -6.28 -0.33 1.08e-9 Coronary artery disease; CRC cis rs7659604 0.605 rs1396080 chr4:122740454 T/G cg20573242 chr4:122745356 CCNA2 0.58 9.07 0.45 1.14e-17 Type 2 diabetes; CRC cis rs9467711 0.790 rs10484439 chr6:26309908 G/A cg12315302 chr6:26189340 HIST1H4D 0.9 6.56 0.34 2.06e-10 Autism spectrum disorder or schizophrenia; CRC trans rs951252 0.504 rs11734405 chr4:146081096 C/T cg14321424 chr11:46403087 MDK 0.48 6.47 0.34 3.57e-10 Hip circumference; CRC trans rs7726839 0.540 rs74553517 chr5:665671 C/T cg11887960 chr12:57824829 NA 0.66 7.1 0.36 7.76e-12 Obesity-related traits; CRC cis rs7945705 0.875 rs10769955 chr11:8784647 G/C cg21881798 chr11:8931708 C11orf17;ST5 0.45 6.45 0.34 3.9e-10 Hemoglobin concentration; CRC cis rs644799 0.710 rs523153 chr11:95570961 G/A cg03916912 chr11:95522834 CEP57;FAM76B 0.87 16.23 0.67 6.25e-44 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs939658 0.935 rs4778651 chr15:79447810 G/A cg17916960 chr15:79447300 NA -0.47 -7.85 -0.4 5.96e-14 Refractive error; CRC cis rs4713118 0.527 rs35949862 chr6:28115367 A/G cg21251018 chr6:28226885 NKAPL 0.48 6.17 0.32 2.02e-9 Parkinson's disease; CRC cis rs13256369 1.000 rs12545771 chr8:8567977 C/G cg00074818 chr8:8560427 CLDN23 0.41 7.36 0.38 1.44e-12 Obesity-related traits; CRC cis rs208520 0.661 rs7766144 chr6:66827795 C/T cg07460842 chr6:66804631 NA -1.1 -15.01 -0.64 3.68e-39 Exhaled nitric oxide output; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg05098230 chr7:92076734 GATAD1 0.38 6.01 0.31 5.03e-9 Liver disease severity in Alagille syndrome; CRC cis rs1552172 0.734 rs9729027 chr1:145592073 A/T cg11743829 chr1:145714124 CD160 0.37 5.66 0.3 3.23e-8 Breast cancer; CRC cis rs72772090 0.539 rs10515248 chr5:96112005 C/T cg17330273 chr5:96107758 CAST;ERAP1 -0.66 -6.04 -0.32 4.12e-9 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC trans rs1005277 0.541 rs2263163 chr10:38389887 G/A cg11292332 chr7:45801988 SEPT13 -0.35 -6.1 -0.32 2.9e-9 Extrinsic epigenetic age acceleration; CRC cis rs11719291 0.833 rs73080361 chr3:48832146 G/A cg01304814 chr3:48885189 PRKAR2A 0.86 6.23 0.32 1.43e-9 Cognitive function; CRC cis rs13108904 0.935 rs13148614 chr4:1248357 G/C cg20092199 chr4:1342459 KIAA1530 0.39 6.76 0.35 6.27e-11 Obesity-related traits; CRC cis rs853679 0.882 rs9366717 chr6:28191057 C/T cg06470822 chr6:28175283 NA 0.86 6.93 0.36 2.27e-11 Depression; CRC cis rs3743266 0.613 rs1063100 chr15:60734697 A/G cg21667061 chr15:60772094 NARG2 -0.29 -5.8 -0.3 1.55e-8 Menarche (age at onset); CRC cis rs2032447 0.867 rs9295683 chr6:26069495 C/T cg12588279 chr6:26043732 HIST1H2BB 0.41 6.2 0.32 1.7e-9 Intelligence (multi-trait analysis); CRC cis rs2014572 1.000 rs3746231 chr19:57760057 G/A cg12963866 chr19:57752005 ZNF805 -0.42 -6.18 -0.32 1.95e-9 Hyperactive-impulsive symptoms; CRC cis rs12612619 0.689 rs1124649 chr2:27260469 G/A cg00617064 chr2:27272375 NA 0.37 5.75 0.3 2.07e-8 Venous thromboembolism adjusted for sickle cell variant rs77121243-T; CRC cis rs854765 0.964 rs2230316 chr17:17997209 C/T cg24612305 chr17:17875800 TOM1L2;LRRC48 -0.49 -7.06 -0.36 9.84e-12 Total body bone mineral density; CRC cis rs13191362 0.935 rs66507030 chr6:162953825 G/A cg06582575 chr6:163149167 PACRG;PARK2 0.79 9.71 0.47 9.3e-20 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs17162190 0.698 rs12093376 chr1:26849973 T/C cg17456097 chr1:26900765 RPS6KA1 0.42 5.94 0.31 7.38e-9 Mean corpuscular volume; CRC trans rs3780486 0.718 rs3818593 chr9:33120706 A/G cg04842962 chr6:43655489 MRPS18A 0.93 11.51 0.54 5.35e-26 IgG glycosylation; CRC cis rs11997175 0.646 rs6984073 chr8:33700070 G/A cg04338863 chr8:33670619 NA 0.43 6.76 0.35 6.28e-11 Body mass index; CRC cis rs2075371 1.000 rs1868783 chr7:133975087 A/G cg20476274 chr7:133979776 SLC35B4 0.81 14.98 0.64 4.65e-39 Mean platelet volume; CRC cis rs9326248 0.773 rs1060211 chr11:117039797 G/A cg11861562 chr11:117069780 TAGLN 0.34 6.22 0.32 1.49e-9 Blood protein levels; CRC cis rs478304 0.593 rs7120713 chr11:65483374 G/C cg05805236 chr11:65401703 PCNXL3 -0.4 -6.3 -0.33 9.68e-10 Acne (severe); CRC cis rs7223966 1.000 rs6504169 chr17:61709145 A/G cg23090583 chr17:61904693 PSMC5;FTSJ3 0.49 6.15 0.32 2.26e-9 Hip circumference adjusted for BMI;Body mass index; CRC cis rs2011503 0.714 rs7250233 chr19:19630948 C/T cg11584989 chr19:19387371 SF4 0.58 6.5 0.34 3e-10 Bipolar disorder; CRC cis rs11608355 0.521 rs7978210 chr12:109835990 A/G cg19025524 chr12:109796872 NA -0.54 -8.5 -0.42 6.87e-16 Neuroticism; CRC cis rs1670533 1.000 rs7669622 chr4:1058659 A/G cg27284194 chr4:1044797 NA 0.51 6.38 0.33 6.02e-10 Recombination rate (females); CRC cis rs7107174 0.901 rs10899496 chr11:78123831 A/G cg02023728 chr11:77925099 USP35 0.37 6.16 0.32 2.15e-9 Testicular germ cell tumor; CRC cis rs4974559 0.739 rs1250121 chr4:1263521 A/G cg02980000 chr4:1222292 CTBP1 -0.68 -7.98 -0.4 2.48e-14 Systolic blood pressure; CRC cis rs1862618 0.802 rs7733041 chr5:56107377 A/C cg24531977 chr5:56204891 C5orf35 -0.76 -10.44 -0.5 3.14e-22 Initial pursuit acceleration; CRC cis rs10450586 1.000 rs10450586 chr11:27308483 G/C cg10370305 chr11:27303972 NA 0.36 5.8 0.3 1.53e-8 Total body bone mineral density; CRC cis rs1707322 1.000 rs785490 chr1:46577124 T/C cg03146154 chr1:46216737 IPP -0.59 -8.06 -0.41 1.44e-14 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC trans rs1728785 1.000 rs1728765 chr16:68589433 G/A cg04657470 chr2:198365150 HSPE1;HSPD1 0.59 7.1 0.36 7.97e-12 Ulcerative colitis; CRC cis rs1524976 1.000 rs9817894 chr3:65465760 T/A cg16238336 chr3:65465873 MAGI1 -0.53 -7.64 -0.39 2.42e-13 PR interval; CRC cis rs4713118 0.513 rs149942 chr6:28001610 T/C cg02631126 chr6:28058918 ZSCAN12L1 0.23 5.63 0.3 3.89e-8 Parkinson's disease; CRC cis rs4665809 0.590 rs35727620 chr2:26458364 G/A cg27170947 chr2:26402098 FAM59B 0.59 7.71 0.39 1.53e-13 Gut microbiome composition (summer); CRC cis rs1862618 0.853 rs6885541 chr5:56110857 G/C cg22800045 chr5:56110881 MAP3K1 0.57 6.14 0.32 2.31e-9 Initial pursuit acceleration; CRC cis rs1707322 0.506 rs2991983 chr1:46079391 T/C cg06784218 chr1:46089804 CCDC17 -0.66 -12.06 -0.55 5.6e-28 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg05733361 chr15:85524456 PDE8A 0.49 6.23 0.32 1.43e-9 Thyroid stimulating hormone; CRC trans rs7308116 0.546 rs2374728 chr12:108227299 A/C cg10318744 chr14:69282256 NA -0.4 -5.96 -0.31 6.37e-9 Pelvic organ prolapse (moderate/severe); CRC cis rs4975709 0.589 rs1684967 chr5:1863055 G/C cg15595755 chr5:1867978 NA 0.43 7.4 0.38 1.17e-12 Cardiovascular disease risk factors; CRC cis rs13108904 0.870 rs2279281 chr4:1245277 T/G cg20092199 chr4:1342459 KIAA1530 0.32 5.76 0.3 1.9e-8 Obesity-related traits; CRC cis rs7043114 0.525 rs2025388 chr9:95128740 T/C cg14631576 chr9:95140430 CENPP -0.31 -5.9 -0.31 8.88e-9 Height; CRC cis rs524281 0.773 rs10791862 chr11:66013664 T/C cg16950941 chr11:66035639 RAB1B -0.7 -8.04 -0.41 1.67e-14 Electroencephalogram traits; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg16025584 chr9:139887217 C9orf142 0.51 6.7 0.35 8.92e-11 Thyroid stimulating hormone; CRC cis rs12908161 0.959 rs3748376 chr15:85328352 C/T cg11189052 chr15:85197271 WDR73 0.59 8.37 0.42 1.72e-15 Schizophrenia; CRC cis rs10504229 1.000 rs17216711 chr8:58170856 T/C cg01721255 chr8:58191610 C8orf71 0.49 6.17 0.32 2e-9 Developmental language disorder (linguistic errors); CRC cis rs9487051 0.735 rs882074 chr6:109611720 C/T cg01475377 chr6:109611718 NA -0.49 -9.24 -0.45 3.04e-18 Reticulocyte fraction of red cells; CRC cis rs798554 0.797 rs35957220 chr7:2812632 C/G cg17321639 chr7:2759063 NA -0.47 -6.05 -0.32 3.92e-9 Height; CRC cis rs12908161 0.959 rs34784022 chr15:85231906 T/C cg17507749 chr15:85114479 UBE2QP1 0.63 8.93 0.44 2.99e-17 Schizophrenia; CRC cis rs561341 0.660 rs7406043 chr17:30220152 C/G cg23018236 chr17:30244563 NA -0.57 -7.15 -0.37 5.62e-12 Hip circumference adjusted for BMI; CRC cis rs2013441 1.000 rs2526483 chr17:20112216 A/G cg13482628 chr17:19912719 NA -0.42 -6.57 -0.34 1.95e-10 Obesity-related traits; CRC cis rs7605827 0.930 rs2380649 chr2:15532612 A/C cg19274914 chr2:15703543 NA 0.39 5.87 0.31 1.06e-8 Educational attainment (years of education); CRC cis rs1003719 0.788 rs2006941 chr21:38467616 C/A cg10648535 chr21:38446584 PIGP;TTC3 0.52 7.41 0.38 1.07e-12 Eye color traits; CRC cis rs12479064 0.724 rs112900993 chr2:99948805 C/G cg14399236 chr2:99771627 LIPT1;TSGA10 -0.61 -7.25 -0.37 3.06e-12 Chronic sinus infection; CRC cis rs7258465 0.965 rs7253990 chr19:18604085 C/G cg10790698 chr19:18539756 SSBP4 -0.45 -8.61 -0.43 3.07e-16 Breast cancer; CRC cis rs9902453 0.780 rs10445384 chr17:28182685 A/G cg26525008 chr17:28256777 EFCAB5;SSH2 0.57 8.58 0.43 3.91e-16 Coffee consumption (cups per day); CRC cis rs10870270 0.956 rs6557 chr10:133781449 C/T cg17892150 chr10:133769511 PPP2R2D -0.75 -10.94 -0.52 5.62e-24 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; CRC cis rs4713118 0.869 rs9461400 chr6:27700559 A/G cg15786705 chr6:28176104 NA 0.54 7.62 0.39 2.72e-13 Parkinson's disease; CRC trans rs2303319 0.504 rs62187612 chr2:162432494 A/G cg11875773 chr22:50468633 TTLL8 -0.7 -6.07 -0.32 3.62e-9 Cognitive function; CRC cis rs72615157 0.664 rs6953580 chr7:99825275 A/G cg00814883 chr7:100076585 TSC22D4 -0.49 -5.98 -0.31 5.72e-9 Lung function (FEV1/FVC); CRC cis rs2976388 0.566 rs2585146 chr8:143798641 A/C cg24046110 chr8:143859143 LYNX1 0.5 7.94 0.4 3.32e-14 Urinary tract infection frequency; CRC cis rs7224737 1.000 rs9889640 chr17:40293497 C/T cg02450064 chr17:40260053 DHX58 -0.42 -6.13 -0.32 2.54e-9 Fibrinogen levels; CRC cis rs1218582 0.772 rs11264290 chr1:154912300 C/T cg06221963 chr1:154839813 KCNN3 -0.75 -14.79 -0.63 2.77e-38 Prostate cancer; CRC cis rs473651 0.935 rs474478 chr2:239335473 C/T cg18131467 chr2:239335373 ASB1 1.02 23.53 0.79 1.79e-72 Multiple system atrophy; CRC cis rs9368481 0.554 rs2754603 chr6:26965139 T/C cg05192639 chr6:26864778 GUSBL1 -0.35 -6.11 -0.32 2.79e-9 Autism spectrum disorder or schizophrenia; CRC cis rs863345 0.548 rs857687 chr1:158577998 T/C cg12129480 chr1:158549410 OR10X1 -0.34 -7.06 -0.36 1e-11 Pneumococcal bacteremia; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg16014136 chr7:89975892 GTPBP10 0.42 6.09 0.32 3.07e-9 Intelligence (multi-trait analysis); CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg24430189 chr2:128173685 NA -0.47 -6.15 -0.32 2.21e-9 Diisocyanate-induced asthma; CRC trans rs916888 0.610 rs199446 chr17:44813169 G/A cg10053473 chr17:62856997 LRRC37A3 0.62 8.77 0.44 9.79e-17 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs1348850 0.914 rs7591807 chr2:178252986 A/G cg22681709 chr2:178499509 PDE11A -0.37 -6.88 -0.35 3.03e-11 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs6723226 0.806 rs6543658 chr2:32718849 G/A cg02381751 chr2:32503542 YIPF4 0.59 8.45 0.42 9.43e-16 Intelligence (multi-trait analysis); CRC cis rs3106136 0.967 rs61514245 chr4:95165053 C/G cg11021082 chr4:95130006 SMARCAD1 -0.46 -7.15 -0.37 5.67e-12 Capecitabine sensitivity; CRC cis rs883565 0.696 rs6599007 chr3:39114445 A/C cg01426195 chr3:39028469 NA -0.54 -8.68 -0.43 1.86e-16 Handedness; CRC cis rs780096 0.526 rs780102 chr2:27659491 T/C cg02592271 chr2:27665507 KRTCAP3 -0.29 -6.69 -0.35 9.47e-11 Total body bone mineral density; CRC cis rs801193 0.967 rs1110414 chr7:66205582 A/G cg11764359 chr7:65958608 NA 0.54 8.25 0.41 3.77e-15 Aortic root size; CRC cis rs7552404 0.731 rs5745491 chr1:76350159 T/G cg10523679 chr1:76189770 ACADM -0.67 -8.2 -0.41 5.57e-15 Blood metabolite levels;Acylcarnitine levels; CRC cis rs2230307 0.536 rs580678 chr1:100483009 C/A cg24955406 chr1:100503596 HIAT1 0.59 7.01 0.36 1.34e-11 Carotid intima media thickness; CRC trans rs7395662 0.571 rs10838947 chr11:48568693 G/T cg00717180 chr2:96193071 NA -0.36 -6.0 -0.31 5.3e-9 HDL cholesterol; CRC cis rs11229555 0.957 rs10896796 chr11:58394256 A/G cg15696309 chr11:58395628 NA -0.95 -13.35 -0.59 8.41e-33 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; CRC cis rs11758351 1.000 rs78012445 chr6:26195080 G/C cg01420254 chr6:26195488 NA 0.81 8.55 0.43 4.7e-16 Gout;Renal underexcretion gout; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg01620991 chr7:66767710 STAG3L4;PMS2L4 0.41 6.04 0.32 4.16e-9 Intelligence (multi-trait analysis); CRC cis rs6952808 0.929 rs2280546 chr7:1976863 G/A cg02951883 chr7:2050386 MAD1L1 -0.7 -10.6 -0.5 8.82e-23 Bipolar disorder and schizophrenia; CRC cis rs877282 0.583 rs7072970 chr10:822757 G/A cg17470449 chr10:769945 NA 0.58 7.88 0.4 4.89e-14 Uric acid levels; CRC trans rs2303319 0.504 rs961421 chr2:162626099 G/C cg13490827 chr1:46269305 MAST2 -0.68 -5.99 -0.31 5.44e-9 Cognitive function; CRC trans rs264943 0.600 rs266055 chr2:104093800 C/A cg24033067 chr14:24674799 TSSK4 -0.41 -6.01 -0.31 4.8e-9 HIV-1 viral setpoint; CRC cis rs644799 0.544 rs555556 chr11:95618425 T/G cg03916912 chr11:95522834 CEP57;FAM76B 0.71 11.83 0.55 3.69e-27 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs4731207 0.735 rs12155120 chr7:124478232 T/C cg23710748 chr7:124431027 NA 0.38 6.08 0.32 3.42e-9 Cutaneous malignant melanoma; CRC cis rs7605827 0.930 rs2111448 chr2:15599073 T/G cg19274914 chr2:15703543 NA 0.39 5.96 0.31 6.58e-9 Educational attainment (years of education); CRC trans rs13046373 0.905 rs4816372 chr21:32077414 A/T cg09765302 chr1:159916077 IGSF9 -0.35 -6.04 -0.32 4.28e-9 HDL cholesterol; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg15559560 chr2:130939084 SMPD4;FAM128B 0.46 6.25 0.33 1.24e-9 Anxiety disorder; CRC cis rs9303280 0.806 rs11078928 chr17:38064469 T/C cg20243544 chr17:37824526 PNMT 0.38 5.65 0.3 3.53e-8 Self-reported allergy; CRC trans rs1376359 0.636 rs12072704 chr1:103123956 A/C cg16220183 chr17:56609687 SEPT4 -0.47 -6.48 -0.34 3.34e-10 QRS duration in Tripanosoma cruzi seropositivity; CRC cis rs2404602 0.631 rs9646213 chr15:76807672 G/C cg22467129 chr15:76604101 ETFA -0.46 -7.62 -0.39 2.65e-13 Blood metabolite levels; CRC cis rs13268772 0.523 rs270054 chr8:3255581 A/G cg23564432 chr8:3253958 CSMD1 0.34 6.27 0.33 1.13e-9 Schizophrenia; CRC cis rs4888262 0.526 rs8057279 chr16:74627303 C/T cg01733217 chr16:74700730 RFWD3 0.79 12.09 0.55 4.48e-28 Testicular germ cell tumor; CRC cis rs11148252 0.553 rs2147692 chr13:53287023 C/G cg20354231 chr13:53171401 NA -0.45 -7.39 -0.38 1.21e-12 Lewy body disease; CRC cis rs4243830 0.649 rs11579888 chr1:6609896 G/A cg05709478 chr1:6581295 PLEKHG5 -0.57 -6.81 -0.35 4.6e-11 Body mass index; CRC cis rs9488822 0.651 rs3798228 chr6:116321156 T/C cg05304507 chr6:116381966 FRK 0.3 8.24 0.41 4.08e-15 Cholesterol, total;LDL cholesterol; CRC cis rs881375 1.000 rs7037140 chr9:123656327 T/C cg14255062 chr9:123606675 PSMD5;LOC253039 0.42 6.03 0.32 4.38e-9 Rheumatoid arthritis; CRC cis rs6502050 0.871 rs6502051 chr17:80059332 A/C cg25804541 chr17:80189381 SLC16A3 0.3 5.63 0.3 3.94e-8 Life satisfaction; CRC cis rs9814567 1.000 rs13096604 chr3:134250099 G/T cg06541857 chr3:134203789 ANAPC13;CEP63 0.4 5.82 0.31 1.38e-8 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs10504229 0.728 rs17804750 chr8:58155751 T/C cg05313129 chr8:58192883 C8orf71 -0.47 -6.18 -0.32 1.94e-9 Developmental language disorder (linguistic errors); CRC cis rs1799949 1.000 rs4793212 chr17:41302750 T/C cg01879757 chr17:41196368 BRCA1 -0.42 -6.24 -0.33 1.31e-9 Menopause (age at onset); CRC cis rs6570726 0.791 rs6900040 chr6:145893134 C/T cg23711669 chr6:146136114 FBXO30 0.69 11.52 0.54 4.94e-26 Lobe attachment (rater-scored or self-reported); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg14842401 chr3:40566302 ZNF621 0.37 6.68 0.35 1.03e-10 Liver disease severity in Alagille syndrome; CRC cis rs6546550 0.901 rs3771531 chr2:70164034 T/C cg02498382 chr2:70120550 SNRNP27 -0.57 -9.62 -0.47 1.87e-19 Prevalent atrial fibrillation; CRC trans rs1005277 0.579 rs2472173 chr10:38374638 G/A cg27523141 chr10:43048294 ZNF37B 0.5 7.33 0.37 1.83e-12 Extrinsic epigenetic age acceleration; CRC cis rs950169 0.887 rs220333 chr15:85091133 C/T cg24253500 chr15:84953950 NA 0.36 5.98 0.31 5.94e-9 Schizophrenia; CRC cis rs2814982 0.605 rs114032116 chr6:34468333 C/T cg14254433 chr6:34482411 PACSIN1 -0.81 -8.61 -0.43 3.08e-16 Cholesterol, total;Total cholesterol levels; CRC cis rs2160860 0.965 rs2543050 chr8:39820296 C/G cg11363097 chr8:39792086 IDO2 -0.35 -5.65 -0.3 3.44e-8 Blood metabolite levels; CRC cis rs2932538 0.922 rs36029940 chr1:113106444 T/G cg22162597 chr1:113214053 CAPZA1 0.7 9.85 0.48 3.1e-20 Systolic blood pressure;Diastolic blood pressure;Hypertension;Blood pressure; CRC cis rs1528435 0.619 rs6745626 chr2:181436641 C/T cg23363182 chr2:181467187 NA -0.41 -6.44 -0.33 4.28e-10 Body mass index; CRC cis rs4604732 0.536 rs12074913 chr1:247631607 G/T cg02104434 chr1:247694406 LOC148824;OR2C3 0.54 8.14 0.41 8.34e-15 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CRC cis rs2180341 0.782 rs4487601 chr6:127723521 A/G cg27446573 chr6:127587934 RNF146 0.72 10.03 0.48 8.03e-21 Breast cancer; CRC cis rs877282 0.853 rs7092652 chr10:756109 G/A cg17470449 chr10:769945 NA 0.61 7.96 0.4 2.78e-14 Uric acid levels; CRC cis rs7659604 1.000 rs7689714 chr4:122665943 T/A cg20573242 chr4:122745356 CCNA2 0.43 6.47 0.34 3.46e-10 Type 2 diabetes; CRC cis rs6500602 0.826 rs11076830 chr16:4460049 A/G cg08645402 chr16:4508243 NA 0.55 7.57 0.39 3.81e-13 Schizophrenia; CRC cis rs4731207 0.596 rs10231491 chr7:124574091 C/T cg23710748 chr7:124431027 NA -0.39 -6.19 -0.32 1.8e-9 Cutaneous malignant melanoma; CRC cis rs9916302 0.653 rs4239223 chr17:37717004 T/C cg00129232 chr17:37814104 STARD3 -0.58 -7.33 -0.37 1.79e-12 Glomerular filtration rate (creatinine); CRC cis rs875971 0.862 rs10274883 chr7:66116091 C/T cg12463550 chr7:65579703 CRCP -0.46 -6.16 -0.32 2.1e-9 Aortic root size; CRC cis rs7923609 0.967 rs10761752 chr10:65160321 T/C cg08743896 chr10:65200160 JMJD1C -0.42 -5.95 -0.31 6.8e-9 Educational attainment;Liver enzyme levels (alkaline phosphatase); CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg21871735 chr16:2015157 SNHG9;RPS2;SNORA78 -0.52 -6.28 -0.33 1.06e-9 Diisocyanate-induced asthma; CRC cis rs3617 0.539 rs4687687 chr3:52948332 A/G cg11645453 chr3:52864694 ITIH4 -0.43 -8.28 -0.42 3.13e-15 Red blood cell count;Autism spectrum disorder or schizophrenia; CRC cis rs1008375 1.000 rs1121090 chr4:17676437 C/G cg16339924 chr4:17578868 LAP3 0.5 6.55 0.34 2.27e-10 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs459193 0.912 rs27984 chr5:55802419 C/T cg26646659 chr5:55776364 NA 0.49 6.72 0.35 7.87e-11 Coronary artery disease;Type 2 diabetes;Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);Waist-to-hip ratio adjusted for BMI in non-smokers;Waist-to-hip ratio adjusted for BMI (smoking interaction);Waist-to-hip ratio adjusted for body mass index;Waist-hip ratio;Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction); CRC cis rs4604732 0.536 rs12037221 chr1:247631212 T/C cg02104434 chr1:247694406 LOC148824;OR2C3 0.54 8.14 0.41 8.34e-15 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CRC cis rs4925386 0.959 rs4925385 chr20:60920624 A/G cg15193198 chr20:60906057 LAMA5 0.44 7.21 0.37 3.8e-12 Colorectal cancer;Colorectal cancer (SNP x SNP interaction); CRC cis rs561341 0.700 rs8079471 chr17:30218317 A/G cg00745463 chr17:30367425 LRRC37B -0.44 -5.95 -0.31 6.81e-9 Hip circumference adjusted for BMI; CRC cis rs478304 1.000 rs478304 chr11:65494260 G/T cg08755490 chr11:65554678 OVOL1 0.41 6.03 0.32 4.51e-9 Acne (severe); CRC trans rs1814175 0.645 rs1721996 chr11:49915527 G/A cg15704280 chr7:45808275 SEPT13 -0.95 -16.82 -0.68 3.11e-46 Height; CRC cis rs1862618 0.853 rs832565 chr5:56150803 T/G cg24531977 chr5:56204891 C5orf35 -0.82 -10.96 -0.52 4.91e-24 Initial pursuit acceleration; CRC cis rs3091242 0.933 rs34933589 chr1:25788198 T/C cg23205692 chr1:25664452 TMEM50A -0.41 -5.75 -0.3 2.02e-8 Erythrocyte sedimentation rate; CRC trans rs4785204 1.000 rs9939710 chr16:50093951 C/T cg07960154 chr17:37760198 NEUROD2 -0.66 -6.13 -0.32 2.45e-9 Esophageal cancer (squamous cell); CRC cis rs1552244 0.882 rs67631672 chr3:10004768 G/A cg10729496 chr3:10149963 C3orf24 0.51 6.7 0.35 9.25e-11 Alzheimer's disease; CRC trans rs2898290 0.578 rs34163377 chr8:11450213 C/G cg06636001 chr8:8085503 FLJ10661 0.54 7.51 0.38 5.65e-13 Systolic blood pressure; CRC cis rs270601 0.683 rs81598 chr5:131587960 C/G cg11843238 chr5:131593191 PDLIM4 0.52 9.01 0.44 1.69e-17 Acylcarnitine levels; CRC cis rs7666738 0.830 rs62321569 chr4:98984250 T/A cg17366294 chr4:99064904 C4orf37 0.43 7.33 0.37 1.76e-12 Colonoscopy-negative controls vs population controls; CRC cis rs11031096 0.738 rs2923950 chr11:4042069 G/C cg18678763 chr11:4115507 RRM1 0.35 5.73 0.3 2.23e-8 Mean corpuscular volume;Mean corpuscular hemoglobin; CRC cis rs72781680 0.611 rs72781692 chr2:24263319 T/G cg06627628 chr2:24431161 ITSN2 -0.54 -5.93 -0.31 7.68e-9 Lymphocyte counts; CRC cis rs4731207 0.594 rs6968500 chr7:124431722 G/C cg23710748 chr7:124431027 NA -0.43 -7.24 -0.37 3.14e-12 Cutaneous malignant melanoma; CRC cis rs711245 0.545 rs848617 chr2:36811298 G/C cg01206211 chr2:36825736 FEZ2 0.43 6.98 0.36 1.62e-11 Height; CRC cis rs8062405 0.755 rs12445823 chr16:28588049 A/C cg05139728 chr16:28306816 SBK1 -0.37 -6.05 -0.32 4.05e-9 Cognitive ability (multi-trait analysis);Cognitive ability; CRC cis rs7917772 0.636 rs7897384 chr10:104529042 T/G cg11453585 chr10:104263688 ACTR1A;SUFU -0.68 -10.16 -0.49 2.94e-21 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC cis rs7959452 0.590 rs7968629 chr12:69782857 G/A cg22834771 chr12:69754056 YEATS4 -0.54 -8.05 -0.41 1.57e-14 Blood protein levels; CRC cis rs7552404 0.690 rs11161620 chr1:76255228 A/G cg03433033 chr1:76189801 ACADM -0.68 -8.95 -0.44 2.65e-17 Blood metabolite levels;Acylcarnitine levels; CRC trans rs1814175 0.586 rs2866862 chr11:49954588 T/C cg11707556 chr5:10655725 ANKRD33B -0.51 -9.82 -0.48 3.9e-20 Height; CRC cis rs950169 0.614 rs765524 chr15:84681782 G/T cg11189052 chr15:85197271 WDR73 0.53 7.38 0.38 1.29e-12 Schizophrenia; CRC cis rs9902453 0.967 rs4429345 chr17:28458105 C/T cg26525008 chr17:28256777 EFCAB5;SSH2 -0.58 -9.14 -0.45 6.6e-18 Coffee consumption (cups per day); CRC cis rs2455601 1.000 rs11042108 chr11:8906021 G/A cg21881798 chr11:8931708 C11orf17;ST5 -0.57 -5.85 -0.31 1.21e-8 Schizophrenia; CRC cis rs6496667 0.730 rs7176776 chr15:91049140 T/G cg04176472 chr15:90893244 GABARAPL3 0.57 8.18 0.41 6.47e-15 Rheumatoid arthritis; CRC cis rs9611565 0.649 rs5758434 chr22:42116163 G/A cg03806693 chr22:41940476 POLR3H 0.67 9.45 0.46 6.78e-19 Vitiligo; CRC cis rs7412746 0.571 rs12402939 chr1:150615094 A/C cg17724175 chr1:150552817 MCL1 0.6 9.57 0.47 2.64e-19 Melanoma; CRC cis rs9649213 0.593 rs12704989 chr7:98029438 G/T cg24562669 chr7:97807699 LMTK2 0.43 7.05 0.36 1.04e-11 Prostate cancer (SNP x SNP interaction); CRC cis rs11628318 0.614 rs7149667 chr14:103129441 G/A cg23071808 chr14:103021642 NA 0.62 6.82 0.35 4.26e-11 Platelet count; CRC cis rs875971 0.505 rs6955582 chr7:65431686 A/G cg02869306 chr7:64672164 INTS4L1 -0.35 -5.9 -0.31 8.87e-9 Aortic root size; CRC trans rs11098499 0.754 rs66900435 chr4:120249425 C/A cg25214090 chr10:38739885 LOC399744 0.53 8.32 0.42 2.41e-15 Corneal astigmatism; CRC cis rs116095464 0.764 rs10069197 chr5:230822 G/C cg22496380 chr5:211416 CCDC127 -0.86 -10.02 -0.48 8.73e-21 Breast cancer; CRC cis rs1800469 1.000 rs1982072 chr19:41864509 T/A cg08477640 chr19:41863820 B9D2 0.58 8.0 0.4 2.2e-14 Colorectal cancer; CRC cis rs875971 0.660 rs801193 chr7:66030612 A/C cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.43 -6.39 -0.33 5.63e-10 Aortic root size; CRC cis rs7223966 1.000 rs8067431 chr17:61817048 T/C cg05941027 chr17:61774174 LIMD2 0.36 6.2 0.32 1.73e-9 Hip circumference adjusted for BMI;Body mass index; CRC trans rs4824093 0.610 rs73443986 chr22:50321193 C/T cg09872104 chr7:134855509 C7orf49 -0.85 -7.8 -0.4 8.48e-14 Amyotrophic lateral sclerosis (sporadic); CRC cis rs10883723 0.810 rs6584507 chr10:104254623 G/A cg11453585 chr10:104263688 ACTR1A;SUFU 0.92 17.58 0.7 2.89e-49 Allergic disease (asthma, hay fever or eczema); CRC cis rs4664293 0.934 rs1365800 chr2:160555623 A/C cg08347373 chr2:160653686 CD302 -0.46 -7.38 -0.38 1.29e-12 Monocyte percentage of white cells; CRC cis rs6456156 0.774 rs6930998 chr6:167526940 A/C cg19688584 chr6:167529678 CCR6 -0.35 -6.42 -0.33 4.63e-10 Primary biliary cholangitis; CRC trans rs2795502 1.000 rs2795497 chr10:43339475 C/A cg06791473 chr12:49259579 RND1 0.61 6.03 0.32 4.5e-9 Blood protein levels; CRC cis rs10463316 0.894 rs954339 chr5:150752161 C/A cg03212797 chr5:150827313 SLC36A1 -0.5 -7.96 -0.4 2.86e-14 Metabolite levels (Pyroglutamine); CRC trans rs13046373 0.905 rs4816372 chr21:32077414 A/T cg26035837 chr20:56885003 RAB22A;PPP4R1L -0.4 -6.03 -0.32 4.44e-9 HDL cholesterol; CRC cis rs9807989 0.507 rs2110659 chr2:103043867 G/A cg03938978 chr2:103052716 IL18RAP 0.59 10.1 0.49 4.49e-21 Asthma; CRC cis rs4363385 0.747 rs4845504 chr1:152960043 G/A cg25856811 chr1:152973957 SPRR3 -0.26 -7.29 -0.37 2.3e-12 Inflammatory skin disease; CRC cis rs4970966 0.904 rs12131809 chr1:150544640 C/T cg17724175 chr1:150552817 MCL1 -0.48 -5.89 -0.31 9.33e-9 Granulocyte percentage of myeloid white cells;Monocyte count;Monocyte percentage of white cells; CRC cis rs7927771 0.832 rs10838698 chr11:47385923 G/A cg20307385 chr11:47447363 PSMC3 0.62 9.21 0.45 4.06e-18 Subjective well-being; CRC cis rs78456975 1.000 rs10208340 chr2:1563100 G/A cg01028140 chr2:1542097 TPO -0.58 -6.07 -0.32 3.5e-9 Placebo response in major depressive disorder (% change in symptom score); CRC cis rs2243480 1.000 rs313809 chr7:65499983 G/A cg25985355 chr7:65971099 NA -0.52 -5.9 -0.31 8.82e-9 Diabetic kidney disease; CRC cis rs6502050 0.835 rs8070014 chr17:80115247 T/G cg13198984 chr17:80129470 CCDC57 0.46 8.18 0.41 6.3e-15 Life satisfaction; CRC cis rs9660180 0.620 rs34298494 chr1:1663402 A/C cg27541892 chr1:1571801 CDK11B -0.59 -8.43 -0.42 1.13e-15 Body mass index; CRC cis rs10411161 0.702 rs6509592 chr19:52393150 G/A cg22331349 chr19:52391350 ZNF577 0.49 6.19 0.32 1.78e-9 Breast cancer; CRC cis rs1448094 0.845 rs7132262 chr12:86346304 C/T cg18827107 chr12:86230957 RASSF9 -0.43 -6.86 -0.35 3.44e-11 Major depressive disorder; CRC cis rs10540 0.730 rs12789735 chr11:518509 G/A cg03576123 chr11:487126 PTDSS2 -1.04 -10.72 -0.51 3.38e-23 Body mass index; CRC trans rs11039798 0.588 rs7116858 chr11:48543920 C/A cg15704280 chr7:45808275 SEPT13 0.65 6.76 0.35 6.47e-11 Axial length; CRC cis rs9910055 0.529 rs228748 chr17:42174390 G/A cg19774624 chr17:42201019 HDAC5 0.53 7.18 0.37 4.67e-12 Total body bone mineral density; CRC cis rs2976388 0.609 rs2717605 chr8:143801015 T/G cg22687807 chr8:143858763 LYNX1 0.49 8.63 0.43 2.73e-16 Urinary tract infection frequency; CRC cis rs2243480 1.000 rs160639 chr7:65579987 C/G cg12463550 chr7:65579703 CRCP 0.66 6.15 0.32 2.28e-9 Diabetic kidney disease; CRC cis rs12477438 0.765 rs72957180 chr2:99694452 G/A cg26064155 chr2:99771622 LIPT1;TSGA10 -0.79 -11.23 -0.53 5.57e-25 Chronic sinus infection; CRC cis rs6951245 0.938 rs78351779 chr7:1097023 G/C cg03188948 chr7:1209495 NA 0.66 6.94 0.36 2.04e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs782590 1.000 rs782590 chr2:55843413 C/T cg18811423 chr2:55921094 PNPT1 0.82 14.84 0.63 1.74e-38 Metabolic syndrome; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg06753787 chr2:220074208 ZFAND2B 0.28 6.02 0.31 4.68e-9 Liver disease severity in Alagille syndrome; CRC cis rs2279817 1.000 rs10788681 chr1:18019524 C/A cg21791023 chr1:18019539 ARHGEF10L 0.51 6.49 0.34 3.2e-10 Neuroticism; CRC cis rs743757 0.878 rs9867588 chr3:50526880 T/C cg08207895 chr3:50388901 TUSC4;CYB561D2 0.43 5.99 0.31 5.58e-9 Diastolic blood pressure; CRC cis rs9611519 0.857 rs4820434 chr22:41637119 G/T cg03806693 chr22:41940476 POLR3H -0.76 -9.88 -0.48 2.55e-20 Neuroticism; CRC cis rs8072100 0.790 rs3760371 chr17:45695914 T/C cg25173405 chr17:45401733 C17orf57 0.39 5.81 0.31 1.45e-8 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs4434138 0.664 rs62255364 chr3:52701502 C/T cg15147215 chr3:52552868 STAB1 -0.64 -10.56 -0.5 1.24e-22 Intelligence (multi-trait analysis); CRC cis rs1707322 1.000 rs785465 chr1:46522577 G/T cg03146154 chr1:46216737 IPP 0.51 6.89 0.36 2.86e-11 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs13118159 0.801 rs1128427 chr4:1330759 T/C cg24560729 chr4:1342394 KIAA1530 0.44 7.8 0.4 8e-14 Longevity; CRC cis rs6694672 1.000 rs4350226 chr1:197132378 G/A cg13682187 chr1:196946512 CFHR5 0.49 7.81 0.4 7.48e-14 Asthma; CRC cis rs6570726 0.577 rs399502 chr6:145805874 A/G cg05347473 chr6:146136440 FBXO30 0.47 6.8 0.35 4.92e-11 Lobe attachment (rater-scored or self-reported); CRC cis rs282587 0.569 rs282598 chr13:113384331 A/G cg04656015 chr13:113407548 ATP11A 0.63 7.9 0.4 4.11e-14 Glycated hemoglobin levels; CRC cis rs10971721 0.822 rs72725392 chr9:33867778 A/G cg13495928 chr9:33750294 PRSS3 0.56 6.05 0.32 3.88e-9 Body mass index; CRC cis rs5753618 0.583 rs5753631 chr22:31863022 A/C cg07713946 chr22:31675144 LIMK2 0.37 5.74 0.3 2.18e-8 Colorectal cancer; CRC cis rs7255436 0.965 rs7249624 chr19:8446135 G/A cg16745616 chr19:8428856 ANGPTL4 -0.44 -6.94 -0.36 2.04e-11 HDL cholesterol; CRC cis rs9487051 0.652 rs9372210 chr6:109601703 G/C cg01475377 chr6:109611718 NA -0.39 -6.67 -0.35 1.05e-10 Reticulocyte fraction of red cells; CRC cis rs12048904 0.541 rs6699536 chr1:101276544 A/G cg00063077 chr1:101360652 SLC30A7;EXTL2 0.68 9.87 0.48 2.66e-20 Multiple sclerosis; CRC cis rs10504229 0.683 rs903702 chr8:58128557 T/C cg05313129 chr8:58192883 C8orf71 -0.43 -6.11 -0.32 2.74e-9 Developmental language disorder (linguistic errors); CRC cis rs950169 0.919 rs12915589 chr15:84734464 T/C cg03959625 chr15:84868606 LOC388152 0.41 6.08 0.32 3.26e-9 Schizophrenia; CRC cis rs11148252 0.967 rs4286007 chr13:53022518 A/G cg12458913 chr13:53173898 NA 0.54 8.61 0.43 3.09e-16 Lewy body disease; CRC cis rs597539 0.652 rs667989 chr11:68685776 T/A cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.87 14.49 0.62 3.92e-37 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs10540 1.000 rs12417570 chr11:462684 C/T cg19913688 chr11:428466 ANO9 -0.72 -6.86 -0.35 3.42e-11 Body mass index; CRC cis rs7847628 0.566 rs10739575 chr9:123606101 A/G cg09419670 chr9:123605666 PSMD5;LOC253039 -0.71 -7.96 -0.4 2.84e-14 Birth weight; CRC cis rs7113874 0.589 rs2028882 chr11:8504854 A/C cg20771178 chr11:8615675 STK33 -0.35 -5.72 -0.3 2.43e-8 Body mass index in physically active individuals;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs3820928 0.605 rs2228555 chr2:227872995 C/T cg11843606 chr2:227700838 RHBDD1 0.46 7.33 0.37 1.83e-12 Pulmonary function; CRC cis rs2075371 1.000 rs432487 chr7:133990114 T/G cg02659138 chr7:134003124 SLC35B4 0.4 6.96 0.36 1.84e-11 Mean platelet volume; CRC cis rs6088590 0.901 rs6087631 chr20:33403509 T/C cg24642439 chr20:33292090 TP53INP2 0.6 10.81 0.51 1.68e-23 Coronary artery disease; CRC cis rs2795502 1.000 rs1581702 chr10:43344246 G/A cg20628663 chr10:43360327 NA 0.69 10.81 0.51 1.62e-23 Blood protein levels; CRC cis rs728616 0.867 rs17884637 chr10:81687922 G/C cg11900509 chr10:81946545 ANXA11 -0.64 -6.66 -0.34 1.14e-10 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs6496667 1.000 rs7162243 chr15:90892631 G/T cg04176472 chr15:90893244 GABARAPL3 0.54 8.13 0.41 8.55e-15 Rheumatoid arthritis; CRC cis rs13191362 0.507 rs13211655 chr6:163177542 C/G cg21926612 chr6:163149169 PACRG;PARK2 0.58 9.11 0.45 8.03e-18 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs12594515 0.591 rs35554150 chr15:45990298 G/A cg22117107 chr15:45993392 NA -0.4 -6.51 -0.34 2.86e-10 Waist circumference;Weight; CRC cis rs73206853 0.698 rs73194015 chr12:111116651 C/T cg12870014 chr12:110450643 ANKRD13A 0.73 6.66 0.34 1.15e-10 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC cis rs5750830 0.546 rs4821891 chr22:39785381 C/T cg24399712 chr22:39784796 NA -0.53 -11.07 -0.52 2.03e-24 Intelligence (multi-trait analysis); CRC cis rs1218582 0.772 rs2102423 chr1:154916068 A/G cg06221963 chr1:154839813 KCNN3 -0.74 -14.41 -0.62 7.9e-37 Prostate cancer; CRC cis rs2739330 0.796 rs5760106 chr22:24250645 A/C cg11905131 chr22:24372483 LOC391322 0.72 11.42 0.53 1.17e-25 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs335206 0.641 rs335210 chr5:122501864 A/G cg16368670 chr5:122501738 PRDM6 -0.29 -6.05 -0.32 3.84e-9 QRS duration; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg17010941 chr8:102218219 ZNF706 0.44 6.28 0.33 1.07e-9 Anxiety disorder; CRC cis rs4689388 0.926 rs10937720 chr4:6295451 A/G cg14416269 chr4:6271139 WFS1 0.4 6.59 0.34 1.72e-10 Type 2 diabetes and other traits;Type 2 diabetes; CRC cis rs225245 0.791 rs4796103 chr17:34025182 A/G cg05299278 chr17:33885742 SLFN14 0.5 8.12 0.41 9.57e-15 Reticulocyte count;Reticulocyte fraction of red cells;High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells; CRC cis rs977987 0.800 rs12922951 chr16:75355096 C/G cg03315344 chr16:75512273 CHST6 0.52 8.8 0.44 7.76e-17 Dupuytren's disease; CRC cis rs6460942 0.908 rs77894875 chr7:12248257 T/C cg06484146 chr7:12443880 VWDE -0.64 -6.35 -0.33 7.2e-10 Coronary artery disease; CRC cis rs7224685 0.501 rs2676276 chr17:3919981 C/T cg11204139 chr17:3907470 NA -0.72 -14.39 -0.62 9.34e-37 Type 2 diabetes; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg16051027 chr20:32320358 ZNF341 0.41 6.03 0.32 4.35e-9 Response to antipsychotic treatment; CRC cis rs875971 0.545 rs1796226 chr7:66087710 C/T cg18876405 chr7:65276391 NA 0.45 6.27 0.33 1.14e-9 Aortic root size; CRC cis rs40363 0.645 rs6501177 chr16:3523681 C/T cg22508957 chr16:3507546 NAT15 0.6 9.41 0.46 8.82e-19 Tuberculosis; CRC trans rs514406 1.000 rs514406 chr1:53330458 A/G cg10287303 chr10:74855401 P4HA1 0.41 6.09 0.32 3.13e-9 Monocyte count; CRC cis rs12477438 0.520 rs13018891 chr2:99755099 C/G cg14399236 chr2:99771627 LIPT1;TSGA10 0.81 14.17 0.62 6.37e-36 Chronic sinus infection; CRC cis rs1997103 1.000 rs2331067 chr7:55408232 A/T cg17469321 chr7:55412551 NA 0.72 11.28 0.53 3.48e-25 QRS interval (sulfonylurea treatment interaction); CRC cis rs6951245 1.000 rs74887741 chr7:1110658 G/T cg20603222 chr7:1096387 C7orf50;GPR146 -0.73 -8.73 -0.43 1.29e-16 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs9649213 0.593 rs1468341 chr7:97987696 G/A cg00277769 chr7:97922759 BAIAP2L1 -0.6 -10.53 -0.5 1.59e-22 Prostate cancer (SNP x SNP interaction); CRC cis rs73206853 0.841 rs60219027 chr12:110759843 T/G cg12870014 chr12:110450643 ANKRD13A 0.8 7.76 0.39 1.1e-13 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC cis rs4132509 0.793 rs74379351 chr1:243779604 T/C cg21452805 chr1:244014465 NA 0.58 6.12 0.32 2.73e-9 RR interval (heart rate); CRC cis rs6842047 0.563 rs10025990 chr4:187146258 T/C cg09526685 chr4:187126073 CYP4V2 0.49 6.32 0.33 8.52e-10 Blood protein levels; CRC cis rs798554 0.757 rs2533878 chr7:2878707 A/G cg19346786 chr7:2764209 NA 0.4 6.84 0.35 3.9e-11 Height; CRC cis rs2040771 0.804 rs2073754 chr22:19221406 G/T cg02655711 chr22:19163373 SLC25A1 -0.52 -8.6 -0.43 3.21e-16 Metabolite levels (small molecules and protein measures); CRC cis rs523522 0.962 rs651627 chr12:121009198 C/T cg12219531 chr12:120966889 COQ5 0.68 9.03 0.45 1.48e-17 High light scatter reticulocyte count; CRC cis rs155076 1.000 rs261404 chr13:21858162 T/G cg21970626 chr13:21893289 NA 0.42 5.83 0.31 1.33e-8 White matter hyperintensity burden; CRC cis rs875971 1.000 rs778699 chr7:65868290 G/A cg11764359 chr7:65958608 NA 0.61 9.95 0.48 1.41e-20 Aortic root size; CRC cis rs1577917 0.518 rs2475787 chr6:86415236 T/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A 0.58 8.42 0.42 1.18e-15 Response to antipsychotic treatment; CRC trans rs1005277 0.579 rs1740735 chr10:38497777 A/C cg27523141 chr10:43048294 ZNF37B 0.47 6.84 0.35 3.98e-11 Extrinsic epigenetic age acceleration; CRC cis rs651907 0.557 rs7612283 chr3:101434919 C/T cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.59 8.0 0.4 2.14e-14 Colorectal cancer; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg24449885 chr12:51718355 BIN2 0.36 5.99 0.31 5.4e-9 Liver disease severity in Alagille syndrome; CRC cis rs4713118 0.662 rs9468274 chr6:28026077 G/T cg18032046 chr6:28092343 ZSCAN16 -0.51 -6.46 -0.34 3.86e-10 Parkinson's disease; CRC cis rs17767392 0.834 rs17767380 chr14:71747031 C/T cg13720639 chr14:72061746 SIPA1L1 -0.53 -6.34 -0.33 7.77e-10 Mitral valve prolapse; CRC cis rs11098499 0.863 rs11098532 chr4:120490726 C/A cg09307838 chr4:120376055 NA 0.68 10.13 0.49 3.48e-21 Corneal astigmatism; CRC trans rs9956878 0.555 rs8085188 chr18:73544676 A/G cg02128981 chr11:58904901 NA 0.37 6.03 0.32 4.48e-9 Obesity-related traits; CRC trans rs2727020 0.566 rs10839234 chr11:49185524 C/T cg11707556 chr5:10655725 ANKRD33B -0.34 -6.28 -0.33 1.04e-9 Coronary artery disease; CRC cis rs2832191 0.716 rs1888439 chr21:30454457 A/G cg08807101 chr21:30365312 RNF160 0.73 11.56 0.54 3.71e-26 Dental caries; CRC cis rs10883723 0.810 rs913025 chr10:104276043 C/T cg11453585 chr10:104263688 ACTR1A;SUFU 0.9 16.72 0.68 7.3e-46 Allergic disease (asthma, hay fever or eczema); CRC cis rs6964587 0.810 rs408 chr7:91556284 A/G cg17063962 chr7:91808500 NA -0.75 -12.75 -0.58 1.51e-30 Breast cancer; CRC cis rs9303280 0.901 rs9303277 chr17:37976469 C/T cg20243544 chr17:37824526 PNMT 0.41 6.48 0.34 3.28e-10 Self-reported allergy; CRC cis rs9303280 0.742 rs11557466 chr17:38024626 C/T cg00129232 chr17:37814104 STARD3 -0.46 -7.3 -0.37 2.24e-12 Self-reported allergy; CRC cis rs7909074 0.691 rs11239274 chr10:45393219 A/C cg04218760 chr10:45406644 TMEM72 0.29 7.82 0.4 7.23e-14 Mean corpuscular volume; CRC cis rs72772090 0.539 rs11739020 chr5:96113838 C/T cg17330273 chr5:96107758 CAST;ERAP1 0.64 6.33 0.33 7.98e-10 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs1559088 0.847 rs2287680 chr19:33608566 A/G cg27124370 chr19:33622961 WDR88 -0.44 -6.12 -0.32 2.67e-9 Bone ultrasound measurement (broadband ultrasound attenuation); CRC cis rs1552244 0.554 rs7638846 chr3:10048601 A/G cg02579736 chr3:10068473 FANCD2;CIDECP 0.68 9.45 0.46 6.67e-19 Alzheimer's disease; CRC cis rs2882667 0.931 rs10074461 chr5:138319815 G/T cg09476006 chr5:138032270 NA 0.39 6.49 0.34 3.21e-10 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs1448094 0.511 rs17280643 chr12:86210154 C/T cg25456477 chr12:86230367 RASSF9 -0.34 -6.14 -0.32 2.39e-9 Major depressive disorder; CRC cis rs6087990 0.735 rs2889703 chr20:31379184 C/A cg13636640 chr20:31349939 DNMT3B 0.67 11.96 0.55 1.27e-27 Ulcerative colitis; CRC cis rs2228479 0.850 rs11641552 chr16:89838700 C/A cg06656553 chr16:89960601 TCF25 -0.7 -5.97 -0.31 6.14e-9 Skin colour saturation; CRC cis rs375066 0.599 rs8106802 chr19:44350096 A/G cg19542119 chr19:44331823 ZNF283 0.4 5.61 0.3 4.24e-8 Breast cancer; CRC cis rs763121 0.853 rs4821809 chr22:39065743 G/C cg06022373 chr22:39101656 GTPBP1 0.8 12.67 0.57 3.21e-30 Menopause (age at onset); CRC cis rs694739 0.536 rs11231740 chr11:64046641 C/T cg24431193 chr11:63883947 FLRT1;MACROD1 -0.37 -5.76 -0.3 1.94e-8 Alopecia areata;Crohn's disease;Psoriasis vulgaris; CRC cis rs10504229 0.636 rs72649123 chr8:58045789 A/T cg02725872 chr8:58115012 NA -0.41 -6.33 -0.33 8.11e-10 Developmental language disorder (linguistic errors); CRC cis rs2380220 0.574 rs9400526 chr6:95998441 T/C cg15832292 chr6:96025679 MANEA 0.56 6.28 0.33 1.08e-9 Behavioural disinhibition (generation interaction); CRC cis rs10971721 0.643 rs10971701 chr9:33781898 A/G cg13495928 chr9:33750294 PRSS3 0.66 5.92 0.31 8.05e-9 Body mass index; CRC cis rs6432018 0.836 rs62119427 chr2:9742068 T/C cg12832956 chr2:9616023 IAH1 -0.37 -5.64 -0.3 3.67e-8 Heart rate variability traits; CRC cis rs9560113 1.000 rs9555810 chr13:112181437 C/G cg10483660 chr13:112241077 NA 0.36 5.79 0.3 1.63e-8 Menarche (age at onset); CRC cis rs13315871 1.000 rs11710058 chr3:58383048 G/A cg20936604 chr3:58311152 NA -0.71 -6.53 -0.34 2.5e-10 Cholesterol, total; CRC cis rs2276314 0.802 rs9963714 chr18:33592056 T/C cg05985134 chr18:33552581 C18orf21 0.49 6.4 0.33 5.32e-10 Endometriosis;Drug-induced torsades de pointes; CRC cis rs6502050 0.835 rs6502070 chr17:80112634 G/A cg02741985 chr17:80059408 CCDC57 0.43 7.11 0.36 7.43e-12 Life satisfaction; CRC cis rs7833986 0.818 rs79824205 chr8:57093233 A/T cg23139584 chr8:56987506 RPS20;SNORD54 0.62 7.53 0.38 4.84e-13 Height; CRC cis rs17270561 0.666 rs17320090 chr6:25720215 C/G cg16482183 chr6:26056742 HIST1H1C 0.73 9.47 0.46 5.57e-19 Iron status biomarkers; CRC cis rs2439831 0.850 rs28891769 chr15:44072860 C/G cg02155558 chr15:43621948 ADAL;LCMT2 0.69 7.61 0.39 2.95e-13 Lung cancer in ever smokers; CRC cis rs2302190 0.882 rs6503869 chr17:56637461 C/G cg25885038 chr17:56607967 SEPT4 -0.51 -7.72 -0.39 1.44e-13 Vitamin D levels; CRC cis rs875971 1.000 rs709597 chr7:65825983 A/G cg18912574 chr7:65842487 NCRNA00174 -0.36 -6.22 -0.32 1.55e-9 Aortic root size; CRC cis rs10504229 0.636 rs72649123 chr8:58045789 A/T cg22535103 chr8:58192502 C8orf71 -0.52 -6.34 -0.33 7.44e-10 Developmental language disorder (linguistic errors); CRC cis rs9916302 0.904 rs7210488 chr17:37539819 T/G cg07936489 chr17:37558343 FBXL20 0.85 13.55 0.6 1.57e-33 Glomerular filtration rate (creatinine); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg14280964 chr1:37940281 ZC3H12A 0.38 6.12 0.32 2.63e-9 Liver disease severity in Alagille syndrome; CRC cis rs4713118 0.869 rs9468214 chr6:27713299 G/C cg12172441 chr6:28176163 NA 0.54 7.44 0.38 8.97e-13 Parkinson's disease; CRC cis rs11758351 0.518 rs79922979 chr6:26224975 A/G cg01420254 chr6:26195488 NA 0.78 8.66 0.43 2.14e-16 Gout;Renal underexcretion gout; CRC cis rs6089584 0.816 rs6061411 chr20:60634716 C/A cg13770153 chr20:60521292 NA -0.56 -8.41 -0.42 1.24e-15 Body mass index; CRC cis rs7944584 0.563 rs61895112 chr11:47560433 T/C cg20307385 chr11:47447363 PSMC3 0.83 11.82 0.55 4.2e-27 Fasting blood glucose;Fasting blood glucose (BMI interaction); CRC cis rs7091068 0.518 rs9633674 chr10:95455431 C/T cg20715218 chr10:95462985 C10orf4 0.57 7.52 0.38 5.4e-13 Urinary tract infection frequency; CRC cis rs4481887 0.830 rs4916126 chr1:248466604 G/A cg00666640 chr1:248458726 OR2T12 0.52 9.22 0.45 3.57e-18 Common traits (Other); CRC cis rs10078 0.559 rs2037077 chr5:447226 A/G cg24955955 chr5:415729 AHRR 0.56 5.62 0.3 4.18e-8 Fat distribution (HIV); CRC cis rs832540 0.669 rs173764 chr5:56198920 C/T cg24531977 chr5:56204891 C5orf35 -0.6 -9.2 -0.45 4.12e-18 Coronary artery disease; CRC cis rs765787 0.505 rs1648302 chr15:45494238 A/G cg24006582 chr15:45444508 DUOX1 -0.52 -7.9 -0.4 4.11e-14 Uric acid levels; CRC cis rs6951245 1.000 rs113146460 chr7:1105164 C/G cg26224354 chr7:1096374 C7orf50;GPR146 -0.94 -12.26 -0.56 9.81e-29 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs13108904 0.870 rs4974577 chr4:1266046 G/A cg02018176 chr4:1364513 KIAA1530 0.45 7.34 0.38 1.64e-12 Obesity-related traits; CRC cis rs10256972 0.681 rs12702016 chr7:1129392 C/T cg23978390 chr7:1156363 C7orf50 0.53 7.41 0.38 1.1e-12 Longevity;Endometriosis; CRC cis rs1448094 0.935 rs4919775 chr12:86339985 T/C cg18827107 chr12:86230957 RASSF9 -0.38 -6.25 -0.33 1.3e-9 Major depressive disorder; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg09378497 chr16:1525169 CLCN7 0.39 6.21 0.32 1.62e-9 Intelligence (multi-trait analysis); CRC cis rs10193935 0.901 rs6544549 chr2:42693056 C/T cg27598129 chr2:42591480 NA 0.68 7.65 0.39 2.23e-13 Colonoscopy-negative controls vs population controls; CRC cis rs1401999 1.000 rs9858774 chr3:183652736 G/A cg20387954 chr3:183756860 HTR3D 0.45 7.63 0.39 2.53e-13 Anterior chamber depth; CRC cis rs6496667 0.779 rs16944424 chr15:90983465 C/T cg04176472 chr15:90893244 GABARAPL3 -0.59 -8.52 -0.43 5.75e-16 Rheumatoid arthritis; CRC cis rs4363385 0.747 rs1984198 chr1:152958584 T/C cg25856811 chr1:152973957 SPRR3 -0.27 -7.45 -0.38 8.07e-13 Inflammatory skin disease; CRC cis rs4964805 0.657 rs4964814 chr12:104189384 A/C cg02344784 chr12:104178138 NT5DC3 -0.78 -14.95 -0.64 6.47e-39 Attention deficit hyperactivity disorder; CRC cis rs4750440 0.733 rs2446585 chr10:14028086 C/T cg00551146 chr10:14014579 FRMD4A 0.41 7.08 0.36 8.72e-12 Adiponectin levels; CRC cis rs875971 0.522 rs781144 chr7:65440344 C/G cg05627663 chr7:65219948 SNORA22;CCT6P1 0.46 6.78 0.35 5.54e-11 Aortic root size; CRC cis rs10744422 0.858 rs10773627 chr12:123311853 A/G cg25930673 chr12:123319894 HIP1R -0.56 -6.1 -0.32 2.96e-9 Schizophrenia; CRC cis rs1348850 0.632 rs4470372 chr2:178505857 G/A cg02961200 chr2:178257176 LOC100130691;AGPS 0.62 8.74 0.43 1.21e-16 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg24981363 chr3:122512705 DIRC2;HSPBAP1 0.43 6.16 0.32 2.17e-9 Intelligence (multi-trait analysis); CRC cis rs172166 0.694 rs203892 chr6:28067196 T/C cg15786705 chr6:28176104 NA 0.63 8.99 0.44 2.02e-17 Cardiac Troponin-T levels; CRC cis rs4713118 0.786 rs200503 chr6:27785882 A/G cg15786705 chr6:28176104 NA 0.5 6.19 0.32 1.81e-9 Parkinson's disease; CRC cis rs1552244 0.882 rs55962400 chr3:10044457 C/T cg13047869 chr3:10149882 C3orf24 0.51 6.46 0.34 3.67e-10 Alzheimer's disease; CRC cis rs2836974 0.623 rs7280326 chr21:40700408 A/G cg11644478 chr21:40555479 PSMG1 -0.62 -9.35 -0.46 1.42e-18 Cognitive function; CRC cis rs11098499 0.863 rs2306456 chr4:120472422 C/G cg24375607 chr4:120327624 NA 0.48 7.26 0.37 2.86e-12 Corneal astigmatism; CRC cis rs3204270 0.759 rs8065104 chr17:79672605 G/A cg09655341 chr17:79618100 PDE6G 0.59 6.75 0.35 6.71e-11 Dental caries; CRC cis rs6502050 0.835 rs8067875 chr17:80092778 C/T cg19223190 chr17:80058835 NA 0.39 6.18 0.32 1.89e-9 Life satisfaction; CRC cis rs9486719 0.522 rs4839683 chr6:96851933 A/G cg06623918 chr6:96969491 KIAA0776 0.74 9.55 0.47 3.19e-19 Migraine;Coronary artery disease; CRC cis rs9296092 0.538 rs76589475 chr6:33519517 G/C cg13560919 chr6:33536144 NA -0.45 -6.28 -0.33 1.07e-9 Age at smoking initiation in chronic obstructive pulmonary disease; CRC cis rs1046896 0.627 rs7225515 chr17:80795783 C/T cg02711726 chr17:80685570 FN3KRP -0.54 -7.26 -0.37 2.83e-12 Glycated hemoglobin levels; CRC cis rs6964587 0.967 rs28594877 chr7:91644070 C/T cg17063962 chr7:91808500 NA 0.83 15.01 0.64 3.56e-39 Breast cancer; CRC cis rs863345 0.604 rs11265024 chr1:158513255 A/G cg12129480 chr1:158549410 OR10X1 -0.33 -6.98 -0.36 1.63e-11 Pneumococcal bacteremia; CRC cis rs4638749 0.734 rs4676191 chr2:108861242 A/G cg25838818 chr2:108905173 SULT1C2 -0.34 -5.83 -0.31 1.32e-8 Blood pressure; CRC cis rs7666738 0.830 rs36047842 chr4:99004902 C/A cg17366294 chr4:99064904 C4orf37 0.44 7.39 0.38 1.19e-12 Colonoscopy-negative controls vs population controls; CRC cis rs875971 0.964 rs55748098 chr7:65763618 T/C cg00343986 chr7:65444356 GUSB -0.43 -6.38 -0.33 6.12e-10 Aortic root size; CRC cis rs3617 0.573 rs9810807 chr3:52924227 C/T cg11645453 chr3:52864694 ITIH4 -0.36 -6.86 -0.35 3.51e-11 Red blood cell count;Autism spectrum disorder or schizophrenia; CRC cis rs2398893 1.000 rs1411861 chr9:96763614 A/G cg14459158 chr9:96720562 NA 0.47 7.31 0.37 2.04e-12 Waist-hip ratio;Waist-to-hip ratio adjusted for body mass index; CRC cis rs1018836 0.544 rs2339154 chr8:91459316 T/C cg16814680 chr8:91681699 NA -0.45 -6.87 -0.35 3.17e-11 Ejection fraction in Tripanosoma cruzi seropositivity; CRC cis rs7739232 0.834 rs17216271 chr6:53529252 C/T cg15658676 chr6:53530538 KLHL31 -0.76 -5.9 -0.31 8.9e-9 Hip circumference adjusted for BMI; CRC cis rs870825 0.860 rs61165411 chr4:185604461 G/A cg04058563 chr4:185651563 MLF1IP 0.65 6.58 0.34 1.87e-10 Blood protein levels; CRC cis rs2274273 0.624 rs10146637 chr14:55744810 G/A cg10130446 chr14:55658398 DLGAP5 -0.42 -6.02 -0.32 4.53e-9 Protein biomarker; CRC cis rs589448 0.902 rs315131 chr12:69761839 T/G cg14784868 chr12:69753453 YEATS4 0.91 17.67 0.7 1.31e-49 Cerebrospinal fluid biomarker levels; CRC cis rs801193 1.000 rs2707854 chr7:66212597 G/A cg18876405 chr7:65276391 NA 0.6 10.61 0.51 7.98e-23 Aortic root size; CRC trans rs11039798 0.588 rs11039807 chr11:48549391 T/A cg03929089 chr4:120376271 NA 0.65 6.96 0.36 1.88e-11 Axial length; CRC cis rs780094 0.500 rs4665987 chr2:27755825 G/A cg27432699 chr2:27873401 GPN1 0.47 6.07 0.32 3.47e-9 Calcium levels;Fasting blood insulin;Metabolic traits;Triglyceride levels;Fasting plasma glucose;Urate levels in overweight individuals;Urate levels in obese individuals;Uric acid levels;Height;Age-related diseases, mortality and associated endophenotypes;Renal underexcretion gout;Fasting blood glucose (BMI interaction);Urate levels;Gondoic acid (20:1n-9) levels;Fasting blood insulin (BMI interaction);Triglycerides;Plasma omega-3 polyunsaturated fatty acid levels (docosapentaenoic acid);Type 2 diabetes;Nonalcoholic fatty liver disease;Hypertriglyceridemia;C-reactive protein;Age-related disease endophenotypes;LDL cholesterol;Metabolic syndrome;Crohn's disease;Alcohol consumption (drinks per week);Homeostasis model assessment of insulin resistance;Alcohol consumption;Red blood cell count;Fasting blood glucose; CRC cis rs9814567 0.806 rs4955525 chr3:134317008 C/T cg06109529 chr3:134205091 CEP63;ANAPC13 -0.69 -10.17 -0.49 2.62e-21 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC trans rs2228479 0.850 rs2302162 chr16:89845287 A/G cg21302420 chr1:112162376 RAP1A 0.72 5.96 0.31 6.33e-9 Skin colour saturation; CRC cis rs9393692 0.905 rs989134 chr6:26336224 A/C cg13736514 chr6:26305472 NA -0.61 -11.45 -0.53 8.96e-26 Educational attainment; CRC cis rs2976388 0.524 rs7012804 chr8:143844650 A/G cg22687807 chr8:143858763 LYNX1 0.61 11.1 0.52 1.56e-24 Urinary tract infection frequency; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg16909824 chr1:151299438 PI4KB 0.41 6.0 0.31 5.19e-9 Intelligence (multi-trait analysis); CRC cis rs7666738 0.830 rs6817645 chr4:99016054 T/C cg17366294 chr4:99064904 C4orf37 0.44 7.35 0.38 1.55e-12 Colonoscopy-negative controls vs population controls; CRC cis rs939574 0.656 rs6710315 chr2:220137991 A/G cg00496455 chr2:220118770 TUBA4A;TUBA4B -0.65 -6.13 -0.32 2.58e-9 Platelet distribution width; CRC cis rs6496667 0.779 rs7170480 chr15:90951639 C/T cg04176472 chr15:90893244 GABARAPL3 0.64 8.14 0.41 8.09e-15 Rheumatoid arthritis; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg19660878 chr19:19774104 ATP13A1 0.45 6.25 0.33 1.28e-9 Anxiety disorder; CRC cis rs6714710 0.580 rs55886305 chr2:98495661 T/G cg26665480 chr2:98280029 ACTR1B 0.52 7.23 0.37 3.38e-12 Posterior cortical atrophy and Alzheimer's disease; CRC cis rs9435341 0.965 rs6669831 chr1:107608607 G/A cg14828511 chr1:107599125 PRMT6 -0.5 -7.25 -0.37 3.01e-12 Facial morphology (factor 21, depth of nasal alae); CRC cis rs13256369 1.000 rs9329165 chr8:8576642 C/T cg18904891 chr8:8559673 CLDN23 -0.55 -7.6 -0.39 3.21e-13 Obesity-related traits; CRC cis rs2404602 0.684 rs2047504 chr15:76883516 A/T cg23625390 chr15:77176239 SCAPER -0.86 -13.8 -0.61 1.7e-34 Blood metabolite levels; CRC trans rs2243480 1.000 rs2707844 chr7:66059509 G/A cg10756647 chr7:56101905 PSPH 0.75 7.84 0.4 6.2e-14 Diabetic kidney disease; CRC cis rs2979489 0.699 rs7840356 chr8:30406251 G/A cg26383811 chr8:30366931 RBPMS 0.66 9.57 0.47 2.61e-19 Mean corpuscular hemoglobin;Plateletcrit;Neutrophil count;Granulocyte count;Sum basophil neutrophil counts;Mean corpuscular volume;Myeloid white cell count;Sum neutrophil eosinophil counts; CRC cis rs2841277 0.646 rs3742935 chr14:105405599 G/C cg14403583 chr14:105418241 AHNAK2 -0.34 -6.03 -0.32 4.43e-9 Rheumatoid arthritis; CRC cis rs67311347 1.000 rs11914297 chr3:40410070 T/C cg24209194 chr3:40518798 ZNF619 0.38 5.7 0.3 2.63e-8 Renal cell carcinoma; CRC cis rs1728785 1.000 rs12918865 chr16:68566546 G/A cg02972257 chr16:68554789 NA -0.58 -7.04 -0.36 1.15e-11 Ulcerative colitis; CRC cis rs3768617 0.706 rs8179460 chr1:183056222 T/C ch.1.3577855R chr1:183094577 LAMC1 0.65 9.87 0.48 2.68e-20 Fuchs's corneal dystrophy; CRC cis rs1799949 1.000 rs1973646 chr17:41310495 T/C cg23758822 chr17:41437982 NA 0.82 13.62 0.6 8.34e-34 Menopause (age at onset); CRC cis rs7647973 0.600 rs35174559 chr3:49287759 T/C cg03060546 chr3:49711283 APEH 0.47 6.98 0.36 1.66e-11 Menarche (age at onset); CRC cis rs11229555 0.874 rs11229519 chr11:58310587 C/T cg15696309 chr11:58395628 NA -0.94 -12.71 -0.57 2.18e-30 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; CRC cis rs9322193 0.923 rs9478291 chr6:150050570 A/G cg05861140 chr6:150128134 PCMT1 -0.37 -5.97 -0.31 6.01e-9 Lung cancer; CRC cis rs2019137 0.936 rs12620738 chr2:113963739 C/T cg12889195 chr2:113992843 PAX8;LOC440839;LOC654433 -0.52 -7.46 -0.38 7.96e-13 Lymphocyte counts; CRC cis rs10924970 0.649 rs10925099 chr1:235366902 C/A cg09010748 chr1:235293032 TOMM20 -0.42 -5.82 -0.31 1.41e-8 Asthma; CRC cis rs10504229 1.000 rs79561699 chr8:58170601 A/G cg01721255 chr8:58191610 C8orf71 0.47 6.03 0.32 4.44e-9 Developmental language disorder (linguistic errors); CRC trans rs3733585 0.699 rs6823361 chr4:9963127 A/G cg26043149 chr18:55253948 FECH -0.48 -7.43 -0.38 9.29e-13 Cleft plate (environmental tobacco smoke interaction); CRC cis rs7809950 1.000 rs10251808 chr7:107120453 G/A cg23024343 chr7:107201750 COG5 -0.62 -8.73 -0.43 1.35e-16 Coronary artery disease; CRC cis rs8141529 0.748 rs6519766 chr22:29269991 A/G cg02153584 chr22:29168773 CCDC117 -0.49 -7.02 -0.36 1.28e-11 Lymphocyte counts; CRC cis rs7113874 0.569 rs4620720 chr11:8615939 G/A cg17679104 chr11:8615758 STK33 0.33 5.67 0.3 3.11e-8 Body mass index in physically active individuals;Body mass index (joint analysis main effects and physical activity interaction); CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg13826709 chr21:46708041 POFUT2;LOC642852 0.45 6.18 0.32 1.91e-9 Anxiety disorder; CRC cis rs4964805 0.672 rs11111757 chr12:104160762 G/C cg02344784 chr12:104178138 NT5DC3 0.45 6.67 0.35 1.07e-10 Attention deficit hyperactivity disorder; CRC trans rs9858542 1.000 rs9812791 chr3:49682311 G/A cg21659725 chr3:3221576 CRBN -0.71 -9.51 -0.46 4.13e-19 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs12762955 0.519 rs10795306 chr10:1019138 A/T cg20503657 chr10:835505 NA -0.45 -6.19 -0.32 1.8e-9 Response to angiotensin II receptor blocker therapy; CRC cis rs2278034 0.578 rs881753 chr3:195606770 C/T cg01181863 chr3:195395398 SDHAP2 0.61 9.05 0.45 1.24e-17 Bronchopulmonary dysplasia; CRC cis rs11711311 1.000 rs2603789 chr3:113470479 T/A cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.52 -7.12 -0.37 6.96e-12 IgG glycosylation; CRC cis rs1799949 0.965 rs9646413 chr17:41426157 A/G cg23758822 chr17:41437982 NA 0.86 15.59 0.65 1.97e-41 Menopause (age at onset); CRC cis rs9326248 1.000 rs4938344 chr11:117003749 G/A cg26566898 chr11:117069891 TAGLN 0.42 8.54 0.43 5.16e-16 Blood protein levels; CRC cis rs9326248 0.768 rs4936366 chr11:117026885 G/A cg26566898 chr11:117069891 TAGLN 0.4 7.12 0.37 6.73e-12 Blood protein levels; CRC cis rs1448094 0.511 rs34885805 chr12:86155180 A/T cg25456477 chr12:86230367 RASSF9 0.39 6.45 0.34 3.89e-10 Major depressive disorder; CRC cis rs7940866 1.000 rs7940866 chr11:130817579 A/T cg12179176 chr11:130786555 SNX19 -0.56 -8.19 -0.41 6.02e-15 Schizophrenia; CRC cis rs6558174 0.714 rs17674754 chr8:22533388 A/G cg03733263 chr8:22462867 KIAA1967 0.5 5.99 0.31 5.65e-9 Breast cancer; CRC cis rs1971762 0.527 rs784562 chr12:53919700 A/C cg06632207 chr12:54070931 ATP5G2 -0.48 -8.16 -0.41 7.32e-15 Height; CRC cis rs34172651 0.876 rs1862451 chr16:24803620 A/G cg00339695 chr16:24857497 SLC5A11 0.27 6.09 0.32 3.13e-9 Intelligence (multi-trait analysis); CRC cis rs7119 0.717 rs12911854 chr15:77817288 T/C cg27398640 chr15:77910606 LINGO1 -0.43 -7.48 -0.38 6.99e-13 Type 2 diabetes; CRC cis rs1005277 0.522 rs7072977 chr10:37940440 C/A cg25517755 chr10:38738941 LOC399744 -0.4 -5.62 -0.3 4.03e-8 Extrinsic epigenetic age acceleration; CRC cis rs2153535 0.505 rs1335629 chr6:8491863 C/T cg21535247 chr6:8435926 SLC35B3 0.49 7.38 0.38 1.3e-12 Motion sickness; CRC cis rs853679 0.517 rs2275508 chr6:28094731 T/C cg21251018 chr6:28226885 NKAPL 0.48 6.33 0.33 8.08e-10 Depression; CRC cis rs7216064 0.953 rs62086043 chr17:65968003 A/G cg12091567 chr17:66097778 LOC651250 -0.59 -7.04 -0.36 1.1e-11 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg05910138 chr5:74632922 HMGCR 0.47 6.89 0.36 2.84e-11 Intelligence (multi-trait analysis); CRC cis rs13256369 0.760 rs7816171 chr8:8575835 T/C cg00074818 chr8:8560427 CLDN23 0.34 6.23 0.32 1.42e-9 Obesity-related traits; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg08228715 chr17:79895357 PYCR1 0.47 6.52 0.34 2.59e-10 Anxiety disorder; CRC cis rs7680126 0.596 rs10805364 chr4:10275518 A/G cg00071950 chr4:10020882 SLC2A9 -0.44 -6.19 -0.32 1.82e-9 Urate levels in lean individuals;Urate levels in overweight individuals;Urate levels in obese individuals; CRC cis rs1552244 0.832 rs73024591 chr3:10203194 A/T cg18598329 chr3:10140678 FANCD2;C3orf24 -0.81 -9.06 -0.45 1.23e-17 Alzheimer's disease; CRC cis rs1348850 0.914 rs1975544 chr2:178465423 G/A cg02961200 chr2:178257176 LOC100130691;AGPS 0.56 7.56 0.38 4.09e-13 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs13108904 0.934 rs13125842 chr4:1280947 G/A cg05665937 chr4:1216051 CTBP1 0.4 5.76 0.3 1.96e-8 Obesity-related traits; CRC cis rs738322 0.934 rs84473 chr22:38557326 T/C cg17652424 chr22:38574118 PLA2G6 -0.22 -6.7 -0.35 8.86e-11 Cutaneous nevi; CRC cis rs2739330 0.587 rs4820571 chr22:24242973 A/G cg11060661 chr22:24314208 DDT;DDTL 0.38 6.27 0.33 1.16e-9 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs1891275 0.515 rs11186666 chr10:93477919 T/C cg07889827 chr10:93443413 NA -0.39 -6.5 -0.34 3.05e-10 Intelligence (multi-trait analysis); CRC cis rs853679 0.517 rs9393887 chr6:28059020 G/A cg03623178 chr6:28175578 NA 0.95 12.51 0.57 1.22e-29 Depression; CRC cis rs11098499 0.954 rs11098524 chr4:120390032 A/G cg24375607 chr4:120327624 NA 0.52 7.91 0.4 4.05e-14 Corneal astigmatism; CRC cis rs2976388 0.609 rs2572899 chr8:143785549 A/G cg20041105 chr8:143859282 LYNX1 0.46 8.18 0.41 6.2e-15 Urinary tract infection frequency; CRC cis rs6860806 0.507 rs2631371 chr5:131703691 G/A cg27615366 chr5:131592974 PDLIM4 -0.33 -5.77 -0.3 1.86e-8 Breast cancer; CRC cis rs2346177 0.846 rs6714738 chr2:46646164 G/A cg26688816 chr2:46740690 ATP6V1E2 -0.52 -8.23 -0.41 4.38e-15 HDL cholesterol; CRC cis rs10089 1.000 rs883074 chr5:127445823 C/T cg25462716 chr5:127418816 SLC12A2;FLJ33630 -0.55 -7.55 -0.38 4.23e-13 Ileal carcinoids; CRC cis rs172166 0.694 rs203877 chr6:28048624 T/C cg15845792 chr6:28175446 NA 0.78 11.62 0.54 2.13e-26 Cardiac Troponin-T levels; CRC cis rs17362650 0.653 rs10929581 chr2:9552379 C/T cg12832956 chr2:9616023 IAH1 -0.49 -6.5 -0.34 2.98e-10 Alcohol dependence (age at onset); CRC cis rs7605827 0.930 rs11902128 chr2:15515269 T/G cg19274914 chr2:15703543 NA 0.4 6.03 0.32 4.33e-9 Educational attainment (years of education); CRC trans rs6951245 0.786 rs77943789 chr7:1140158 C/T cg13565492 chr6:43139072 SRF -0.76 -8.43 -0.42 1.1e-15 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs6952808 0.542 rs10243920 chr7:1950385 G/A cg21782813 chr7:2030301 MAD1L1 0.4 7.28 0.37 2.55e-12 Bipolar disorder and schizophrenia; CRC cis rs9905704 0.918 rs694720 chr17:56708019 T/C cg12560992 chr17:57184187 TRIM37 0.56 7.63 0.39 2.5e-13 Testicular germ cell tumor; CRC cis rs7632954 0.567 rs6768518 chr3:8534828 G/A cg03495237 chr3:8533978 NA 0.35 6.38 0.33 5.85e-10 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs4494114 0.967 rs9438980 chr1:39355371 A/G cg25970120 chr1:39325951 RRAGC -0.42 -5.78 -0.3 1.77e-8 Blood protein levels; CRC cis rs1387259 0.931 rs1107654 chr12:48681097 T/G cg24011408 chr12:48396354 COL2A1 0.45 6.32 0.33 8.27e-10 Obstructive sleep apnea trait (apnea hypopnea index); CRC cis rs6840360 1.000 rs4696284 chr4:152595836 C/G cg09659197 chr4:152720779 NA 0.52 11.24 0.53 4.87e-25 Intelligence (multi-trait analysis); CRC cis rs57221529 0.766 rs12522303 chr5:555564 A/C cg09021430 chr5:549028 NA -0.72 -8.17 -0.41 6.5e-15 Lung disease severity in cystic fibrosis; CRC cis rs6951245 0.706 rs28522260 chr7:1183964 C/A cg20603222 chr7:1096387 C7orf50;GPR146 -0.64 -7.85 -0.4 5.76e-14 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs2289583 0.500 rs67168917 chr15:75391494 G/T cg09165964 chr15:75287851 SCAMP5 -0.51 -7.94 -0.4 3.22e-14 Systemic lupus erythematosus; CRC trans rs208520 0.690 rs3843513 chr6:66836797 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.08 -14.85 -0.63 1.53e-38 Exhaled nitric oxide output; CRC cis rs7927592 0.956 rs6591341 chr11:68335478 C/T cg16797656 chr11:68205561 LRP5 0.39 6.69 0.35 9.85e-11 Total body bone mineral density; CRC cis rs7659604 0.539 rs11098648 chr4:122759872 C/T cg06713675 chr4:122721982 EXOSC9 -0.51 -8.23 -0.41 4.48e-15 Type 2 diabetes; CRC cis rs801193 0.569 rs35070132 chr7:66238083 C/T cg18876405 chr7:65276391 NA 0.49 7.72 0.39 1.42e-13 Aortic root size; CRC cis rs1865760 0.566 rs9366634 chr6:26072396 C/G cg18357526 chr6:26021779 HIST1H4A 0.43 6.11 0.32 2.85e-9 Height; CRC cis rs990171 1.000 rs4851588 chr2:103073505 C/G cg03938978 chr2:103052716 IL18RAP 0.46 5.87 0.31 1.09e-8 Lymphocyte counts; CRC cis rs709400 0.663 rs62007718 chr14:103940436 G/A cg12935359 chr14:103987150 CKB -0.51 -7.91 -0.4 3.85e-14 Body mass index; CRC cis rs250677 0.958 rs36070 chr5:148417240 T/C cg23229984 chr5:148520753 ABLIM3 0.49 6.78 0.35 5.73e-11 Breast cancer; CRC cis rs539514 0.690 rs1092601 chr13:76309746 C/T cg04757411 chr13:76259545 LMO7 -0.35 -5.87 -0.31 1.06e-8 Type 1 diabetes; CRC cis rs2153535 0.580 rs9393016 chr6:8458573 T/A cg21535247 chr6:8435926 SLC35B3 0.51 7.9 0.4 4.36e-14 Motion sickness; CRC trans rs10504229 1.000 rs66870803 chr8:58180022 G/C cg04077850 chr5:125800366 GRAMD3 0.37 6.27 0.33 1.15e-9 Developmental language disorder (linguistic errors); CRC trans rs7647973 0.626 rs11709734 chr3:49745235 G/A cg21659725 chr3:3221576 CRBN -0.66 -7.53 -0.38 4.98e-13 Menarche (age at onset); CRC cis rs13108904 0.901 rs6851528 chr4:1296009 G/A cg24560729 chr4:1342394 KIAA1530 0.31 5.65 0.3 3.43e-8 Obesity-related traits; CRC cis rs58688157 0.705 rs12800061 chr11:587425 C/A cg07212818 chr11:638076 DRD4 -0.46 -5.87 -0.31 1.07e-8 Systemic lupus erythematosus; CRC cis rs10078 0.559 rs2671891 chr5:456386 A/G cg26072250 chr5:443457 EXOC3;C5orf55 0.59 5.84 0.31 1.23e-8 Fat distribution (HIV); CRC cis rs7107174 1.000 rs2511166 chr11:77964331 T/C cg02023728 chr11:77925099 USP35 0.5 8.41 0.42 1.22e-15 Testicular germ cell tumor; CRC cis rs9916302 0.904 rs634365 chr17:37436966 C/T cg15445000 chr17:37608096 MED1 0.39 8.58 0.43 3.71e-16 Glomerular filtration rate (creatinine); CRC cis rs4919087 1.000 rs11189127 chr10:99079023 G/A cg25902810 chr10:99078978 FRAT1 0.4 6.12 0.32 2.65e-9 Monocyte count; CRC cis rs6951245 0.872 rs112309216 chr7:1100296 A/T cg18402987 chr7:1209562 NA 0.67 7.17 0.37 5.02e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs4363385 0.720 rs6672735 chr1:152981086 A/G cg25856811 chr1:152973957 SPRR3 -0.25 -6.76 -0.35 6.27e-11 Inflammatory skin disease; CRC cis rs1862618 0.641 rs170733 chr5:56249251 A/G cg03609598 chr5:56110824 MAP3K1 0.6 8.15 0.41 7.56e-15 Initial pursuit acceleration; CRC cis rs7605827 0.860 rs6760297 chr2:15632472 T/C cg19274914 chr2:15703543 NA 0.39 5.9 0.31 8.83e-9 Educational attainment (years of education); CRC cis rs763014 1.000 rs763014 chr16:675680 T/C cg00802000 chr16:706648 WDR90 -0.44 -6.31 -0.33 8.99e-10 Height; CRC cis rs12887734 0.546 rs4906376 chr14:104272165 A/C cg01849466 chr14:104193079 ZFYVE21 -0.5 -7.11 -0.36 7.42e-12 Schizophrenia;Autism spectrum disorder or schizophrenia; CRC trans rs7395662 0.504 rs11039701 chr11:48389838 A/G cg15704280 chr7:45808275 SEPT13 -0.48 -6.95 -0.36 2.01e-11 HDL cholesterol; CRC cis rs9640161 0.742 rs11767726 chr7:150018096 A/C cg13722127 chr7:150037890 RARRES2 -0.47 -7.64 -0.39 2.38e-13 Blood protein levels;Circulating chemerin levels; CRC cis rs6502050 0.835 rs7502548 chr17:80087569 T/C cg25804541 chr17:80189381 SLC16A3 0.31 6.01 0.31 4.92e-9 Life satisfaction; CRC cis rs10486722 0.651 rs4720404 chr7:41776699 G/A cg22138096 chr7:41772439 LOC285954 0.48 6.2 0.32 1.7e-9 Pit-and-Fissure caries; CRC cis rs2276314 0.857 rs59649576 chr18:33616075 G/T cg05985134 chr18:33552581 C18orf21 0.51 7.03 0.36 1.19e-11 Endometriosis;Drug-induced torsades de pointes; CRC cis rs875971 1.000 rs6963646 chr7:65685767 T/C cg00343986 chr7:65444356 GUSB -0.45 -6.68 -0.35 1.03e-10 Aortic root size; CRC cis rs3617 0.625 rs2240915 chr3:52859526 T/A cg11645453 chr3:52864694 ITIH4 0.46 9.25 0.45 2.91e-18 Red blood cell count;Autism spectrum disorder or schizophrenia; CRC cis rs7191439 0.789 rs4433802 chr16:88784964 A/G cg02389323 chr16:88786976 FAM38A 1.0 8.56 0.43 4.4e-16 Plateletcrit; CRC cis rs651907 0.514 rs10936744 chr3:101433440 C/T cg11279151 chr3:101281821 RG9MTD1 -0.55 -7.56 -0.38 4.16e-13 Colorectal cancer; CRC cis rs4731207 0.596 rs9640828 chr7:124655481 A/C cg23710748 chr7:124431027 NA -0.39 -6.25 -0.33 1.24e-9 Cutaneous malignant melanoma; CRC cis rs2549003 0.933 rs3846731 chr5:131814264 T/C cg00255919 chr5:131827918 IRF1 0.59 11.92 0.55 1.8e-27 Asthma (sex interaction); CRC cis rs12477438 0.834 rs1563106 chr2:99701381 C/A cg26064155 chr2:99771622 LIPT1;TSGA10 -0.64 -8.91 -0.44 3.5e-17 Chronic sinus infection; CRC cis rs9911578 0.874 rs302874 chr17:56767996 A/G cg12560992 chr17:57184187 TRIM37 0.85 15.15 0.64 1.08e-39 Intelligence (multi-trait analysis); CRC cis rs853679 0.517 rs9380059 chr6:28132358 A/C cg18032046 chr6:28092343 ZSCAN16 -0.51 -5.93 -0.31 7.47e-9 Depression; CRC cis rs1062746 0.544 rs8059287 chr16:87332956 G/A cg02258303 chr16:87377426 FBXO31 -0.51 -7.34 -0.37 1.73e-12 Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 2 peripheral neuropathy); CRC trans rs330048 0.545 rs11249913 chr8:9143521 G/T cg06636001 chr8:8085503 FLJ10661 -0.48 -6.53 -0.34 2.55e-10 Systemic lupus erythematosus; CRC cis rs847577 0.540 rs3847055 chr7:97680645 A/G cg21770322 chr7:97807741 LMTK2 -0.56 -8.03 -0.4 1.78e-14 Breast cancer; CRC cis rs9814567 1.000 rs9289475 chr3:134236459 G/A cg06109529 chr3:134205091 CEP63;ANAPC13 -0.82 -12.18 -0.56 2.02e-28 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC trans rs2727020 0.521 rs2088526 chr11:49531968 G/A cg11707556 chr5:10655725 ANKRD33B 0.47 7.6 0.39 3.2e-13 Coronary artery disease; CRC cis rs1568889 0.838 rs10835276 chr11:28167147 C/T cg06544937 chr11:28130018 METT5D1;KIF18A 0.91 15.29 0.64 2.98e-40 Bipolar disorder; CRC cis rs11255291 0.668 rs719748 chr10:7731885 A/G cg00997801 chr10:7671259 ITIH5 0.41 6.18 0.32 1.9e-9 Ovarian reserve; CRC cis rs13108904 0.557 rs1680033 chr4:1243404 C/T cg20092199 chr4:1342459 KIAA1530 -0.38 -6.09 -0.32 3.22e-9 Obesity-related traits; CRC cis rs4690686 0.500 rs7683662 chr4:177272004 A/T cg17059388 chr4:177262070 NA 0.38 5.69 0.3 2.87e-8 Essential tremor; CRC cis rs10504073 0.647 rs62507246 chr8:50013449 G/A cg00325661 chr8:49890786 NA 0.52 9.3 0.46 1.98e-18 Blood metabolite ratios; CRC cis rs477692 0.870 rs532248 chr10:131414156 T/A cg05714579 chr10:131428358 MGMT 0.57 8.31 0.42 2.63e-15 Response to temozolomide; CRC cis rs72717009 0.778 rs9427400 chr1:161477204 C/T cg23840854 chr1:161414152 NA -0.67 -8.14 -0.41 8.07e-15 Rheumatoid arthritis; CRC cis rs4692589 0.931 rs12647236 chr4:170966255 A/T cg19918862 chr4:170955249 NA -0.38 -6.17 -0.32 2.01e-9 Anxiety disorder; CRC cis rs921968 0.643 rs62191565 chr2:219482017 C/T cg02176678 chr2:219576539 TTLL4 0.49 8.27 0.42 3.26e-15 Mean corpuscular hemoglobin concentration; CRC cis rs10504229 0.593 rs76118562 chr8:57988110 G/C cg22535103 chr8:58192502 C8orf71 -0.63 -6.65 -0.34 1.2e-10 Developmental language disorder (linguistic errors); CRC cis rs8072100 0.875 rs12451409 chr17:45544856 A/G cg08085267 chr17:45401833 C17orf57 -0.6 -9.46 -0.46 6.22e-19 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs6908034 0.607 rs77753186 chr6:19812980 G/C cg02682789 chr6:19804855 NA 0.81 6.48 0.34 3.35e-10 Endometriosis;Deep ovarian and/or rectovaginal disease with dense adhesions; CRC cis rs2842992 0.915 rs1322427 chr6:160075454 C/A cg19482086 chr6:160211437 TCP1;MRPL18 0.68 8.56 0.43 4.28e-16 Age-related macular degeneration (geographic atrophy); CRC cis rs3741404 0.825 rs11603384 chr11:63949095 G/A cg19465662 chr11:63993652 NUDT22;TRPT1 0.89 14.46 0.62 5.11e-37 Platelet count; CRC cis rs2382817 0.580 rs6756265 chr2:219095554 G/A cg04731861 chr2:219085781 ARPC2 0.37 7.99 0.4 2.37e-14 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; CRC cis rs9443645 0.527 rs10943595 chr6:79575291 C/G cg09184832 chr6:79620586 NA -0.47 -8.22 -0.41 4.67e-15 Intelligence (multi-trait analysis); CRC cis rs11690935 0.921 rs908670 chr2:172690180 T/C cg13550731 chr2:172543902 DYNC1I2 -1.08 -18.07 -0.71 3.63e-51 Schizophrenia; CRC cis rs4780401 0.587 rs9931332 chr16:11807517 G/C cg01061890 chr16:11836724 TXNDC11 -0.62 -9.12 -0.45 7.73e-18 Rheumatoid arthritis; CRC cis rs4285028 0.656 rs2141487 chr3:121482765 A/G cg11130432 chr3:121712080 ILDR1 0.5 5.93 0.31 7.69e-9 Multiple sclerosis; CRC trans rs6075982 0.749 rs6082953 chr20:22947557 C/T cg03184243 chr8:28347962 FBXO16 0.49 6.11 0.32 2.76e-9 Obesity-related traits; CRC cis rs8014204 0.901 rs4899536 chr14:75316614 A/G cg03030879 chr14:75389066 RPS6KL1 0.53 8.51 0.42 6.42e-16 Caffeine consumption; CRC cis rs977987 0.806 rs1544810 chr16:75411163 A/T cg03315344 chr16:75512273 CHST6 0.53 8.85 0.44 5.48e-17 Dupuytren's disease; CRC cis rs9443645 0.901 rs4421161 chr6:79564219 A/G cg05283184 chr6:79620031 NA 0.58 9.27 0.46 2.5e-18 Intelligence (multi-trait analysis); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg04688917 chr3:179040469 ZNF639 0.43 6.01 0.31 5e-9 Response to antipsychotic treatment; CRC cis rs12497850 0.931 rs9311434 chr3:48884147 T/C cg20833759 chr3:49053208 WDR6;DALRD3 0.48 8.17 0.41 6.8e-15 Parkinson's disease; CRC cis rs6499255 1.000 rs11075733 chr16:69773435 G/T cg04110750 chr16:69646130 NFAT5 -0.53 -7.1 -0.36 7.5e-12 IgE levels; CRC cis rs743757 1.000 rs2236955 chr3:50429876 G/A cg08207895 chr3:50388901 TUSC4;CYB561D2 0.45 6.0 0.31 5.14e-9 Diastolic blood pressure; CRC cis rs76878669 0.561 rs1039594 chr11:66131149 C/T cg24851651 chr11:66362959 CCS -0.38 -6.62 -0.34 1.49e-10 Educational attainment (years of education); CRC cis rs3796352 1.000 rs34943350 chr3:53012888 C/T cg06204229 chr3:52865917 ITIH4 0.51 5.86 0.31 1.13e-8 Immune reponse to smallpox (secreted IL-2); CRC trans rs9858542 0.953 rs9837341 chr3:49664767 A/G cg21659725 chr3:3221576 CRBN -0.69 -9.07 -0.45 1.1e-17 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs910187 0.571 rs6512428 chr20:45807822 T/C cg27589058 chr20:45804311 EYA2 -0.4 -7.69 -0.39 1.7e-13 Migraine; CRC cis rs2252790 1.000 rs3021301 chr6:116670364 A/G cg18764771 chr6:116381957 FRK -0.22 -5.8 -0.3 1.59e-8 Fast beta electroencephalogram; CRC cis rs3750082 0.889 rs9639669 chr7:32913395 T/C cg05721444 chr7:32995514 FKBP9 0.51 7.87 0.4 5.33e-14 Glomerular filtration rate (creatinine); CRC cis rs294883 0.858 rs453265 chr6:159698936 C/T cg14500486 chr6:159655392 FNDC1 -0.36 -5.82 -0.31 1.4e-8 Coronary artery disease; CRC cis rs9649213 0.555 rs12667634 chr7:97965442 A/G cg24562669 chr7:97807699 LMTK2 0.43 7.15 0.37 5.67e-12 Prostate cancer (SNP x SNP interaction); CRC cis rs6952808 0.689 rs12668156 chr7:2019875 G/A cg02951883 chr7:2050386 MAD1L1 -0.76 -11.92 -0.55 1.8e-27 Bipolar disorder and schizophrenia; CRC cis rs12188164 0.502 rs55929184 chr5:405576 G/A cg26850624 chr5:429559 AHRR -0.72 -11.23 -0.53 5.67e-25 Cystic fibrosis severity; CRC cis rs3733585 0.699 rs7658170 chr4:9966593 C/T cg11266682 chr4:10021025 SLC2A9 0.46 9.09 0.45 9.66e-18 Cleft plate (environmental tobacco smoke interaction); CRC cis rs6912958 0.703 rs9359748 chr6:88095500 C/T cg04972856 chr6:88032051 C6orf162;GJB7 0.34 6.25 0.33 1.24e-9 Monocyte percentage of white cells; CRC cis rs2836974 0.627 rs8127986 chr21:40687211 A/T cg11890956 chr21:40555474 PSMG1 -0.84 -13.9 -0.61 6.99e-35 Cognitive function; CRC cis rs9372498 0.536 rs9489428 chr6:118852935 T/C cg10217327 chr6:118973057 C6orf204 0.51 5.78 0.3 1.73e-8 Diastolic blood pressure; CRC cis rs2836974 0.931 rs12151994 chr21:40690397 A/C cg06238570 chr21:40685208 BRWD1 0.75 10.23 0.49 1.63e-21 Cognitive function; CRC cis rs873946 0.504 rs12775990 chr10:134575836 C/T cg06453172 chr10:134556979 INPP5A -0.64 -8.05 -0.41 1.5e-14 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg27430182 chr3:126195181 ZXDC 0.43 6.11 0.32 2.77e-9 Response to antipsychotic treatment; CRC cis rs1552244 0.766 rs34232505 chr3:10186216 T/A cg10729496 chr3:10149963 C3orf24 0.59 7.7 0.39 1.62e-13 Alzheimer's disease; CRC cis rs1030877 0.515 rs920217 chr2:105904662 C/T cg02079111 chr2:105885981 TGFBRAP1 -0.46 -6.33 -0.33 7.88e-10 Obesity-related traits; CRC cis rs7618501 0.633 rs11130234 chr3:50024758 G/T cg24110177 chr3:50126178 RBM5 -0.47 -7.02 -0.36 1.26e-11 Intelligence (multi-trait analysis); CRC cis rs7618915 0.547 rs35211965 chr3:52685305 C/G cg10802521 chr3:52805072 NEK4 -0.58 -8.85 -0.44 5.34e-17 Bipolar disorder; CRC cis rs6502050 0.835 rs7222057 chr17:80087647 C/A cg09264619 chr17:80180166 NA -0.37 -6.13 -0.32 2.51e-9 Life satisfaction; CRC trans rs951252 0.504 rs11734405 chr4:146081096 C/T cg23355997 chr17:7154831 DULLARD;C17orf81 0.49 6.46 0.34 3.87e-10 Hip circumference; CRC cis rs7918232 0.941 rs10829195 chr10:27431564 G/A cg14240646 chr10:27532245 ACBD5 -0.85 -9.81 -0.48 4.13e-20 Breast cancer; CRC cis rs9341808 0.791 rs1324122 chr6:80946061 G/A cg08355045 chr6:80787529 NA 0.42 6.81 0.35 4.67e-11 Sitting height ratio; CRC cis rs34779708 0.931 rs6481935 chr10:35342959 C/T cg03585969 chr10:35415529 CREM 0.6 8.14 0.41 8.07e-15 Inflammatory bowel disease;Crohn's disease; CRC cis rs6496044 0.568 rs12708554 chr15:86074297 C/G cg17133734 chr15:86042851 AKAP13 0.41 6.68 0.35 1.03e-10 Interstitial lung disease; CRC cis rs720844 0.684 rs10928404 chr2:149311747 A/T cg09247360 chr2:149335327 NA -0.56 -5.75 -0.3 2.01e-8 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs2857891 0.817 rs2638094 chr11:6981488 A/G cg22096450 chr11:6947773 ZNF215 0.61 6.21 0.32 1.63e-9 Response to cytadine analogues (cytosine arabinoside); CRC cis rs35110281 0.565 rs7278003 chr21:44966069 T/C cg04455712 chr21:45112962 RRP1B 0.41 7.79 0.39 9.1e-14 Mean corpuscular volume; CRC cis rs28386778 0.897 rs4968663 chr17:61835603 A/T cg22520471 chr17:61851767 DDX42;CCDC47 0.74 11.6 0.54 2.6e-26 Prudent dietary pattern; CRC cis rs10504229 0.683 rs55986917 chr8:58137210 C/T cg02290350 chr8:58132656 NA -0.58 -8.16 -0.41 7.29e-15 Developmental language disorder (linguistic errors); CRC cis rs4700695 0.841 rs153367 chr5:65419170 G/A cg21114390 chr5:65439923 SFRS12 -0.53 -6.27 -0.33 1.16e-9 Facial morphology (factor 19); CRC cis rs11148252 0.553 rs9536219 chr13:53227301 C/T cg02158880 chr13:53174818 NA 0.54 8.55 0.43 4.56e-16 Lewy body disease; CRC cis rs12458462 0.859 rs2242177 chr18:77477379 G/A cg11879182 chr18:77439856 CTDP1 0.72 11.46 0.53 8.31e-26 Monocyte count; CRC cis rs6762 0.748 rs3059 chr11:840319 C/T cg15787769 chr11:842744 TSPAN4;POLR2L -0.46 -6.51 -0.34 2.84e-10 Mean platelet volume; CRC cis rs860295 0.702 rs11264386 chr1:155559170 G/T cg02153340 chr1:155202674 NA -0.58 -6.75 -0.35 6.59e-11 Body mass index; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg15680518 chr12:132414800 PUS1 0.46 6.18 0.32 1.88e-9 Thyroid stimulating hormone; CRC cis rs6740322 0.895 rs6760797 chr2:43559612 G/A cg06169590 chr2:43455088 ZFP36L2;LOC100129726 -0.66 -8.12 -0.41 9.57e-15 Coronary artery disease; CRC cis rs11212617 0.967 rs620613 chr11:108185478 C/T cg01991180 chr11:108092276 ATM;NPAT 0.39 5.63 0.3 3.88e-8 Response to metformin in type 2 diabetes (glycemic); CRC trans rs11148252 0.500 rs342768 chr13:53208882 C/T cg18335740 chr13:41363409 SLC25A15 0.77 13.83 0.61 1.26e-34 Lewy body disease; CRC cis rs7954584 0.567 rs11043251 chr12:122373279 C/T cg22618164 chr12:122356400 WDR66 0.37 5.61 0.3 4.23e-8 Mean corpuscular volume; CRC cis rs6570726 0.791 rs422099 chr6:145806936 C/T cg13319975 chr6:146136371 FBXO30 -0.46 -6.84 -0.35 3.79e-11 Lobe attachment (rater-scored or self-reported); CRC cis rs57590327 0.555 rs13072957 chr3:81776242 A/G cg07356753 chr3:81810745 GBE1 0.65 8.76 0.43 1.06e-16 Extraversion; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg27493885 chr12:95467123 NR2C1 0.43 5.97 0.31 6.06e-9 Anxiety disorder; CRC cis rs17376456 0.825 rs6898842 chr5:93213221 T/C cg09848695 chr5:92956644 FAM172A;MIR2277 0.68 5.81 0.31 1.48e-8 Diabetic retinopathy; CRC cis rs736408 0.609 rs1029871 chr3:52797634 G/C cg18404041 chr3:52824283 ITIH1 -0.43 -8.77 -0.44 1e-16 Bipolar disorder; CRC cis rs2281845 0.965 rs3738263 chr1:201083506 A/G cg01987224 chr1:201084466 NA 0.53 9.98 0.48 1.15e-20 Permanent tooth development; CRC cis rs4148883 0.675 rs11724783 chr4:100099688 C/A cg13256891 chr4:100009986 ADH5 0.42 6.09 0.32 3.07e-9 Alcohol dependence; CRC cis rs12024301 0.557 rs75012526 chr1:183596921 C/T cg11505048 chr1:183622726 RGL1;APOBEC4 0.76 6.93 0.36 2.16e-11 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs10197940 0.638 rs2288193 chr2:152348842 T/A cg06191203 chr2:152266755 RIF1 -0.73 -10.51 -0.5 1.85e-22 Lung cancer; CRC cis rs10504073 0.669 rs62507251 chr8:50028524 T/G cg00325661 chr8:49890786 NA 0.53 9.49 0.46 4.72e-19 Blood metabolite ratios; CRC trans rs6703335 0.870 rs10803142 chr1:243598234 A/G cg07491357 chr18:9914943 VAPA 0.49 6.87 0.35 3.23e-11 Schizophrenia;Schizophrenia, schizoaffective disorder or bipolar disorder; CRC cis rs1559088 0.739 rs9304845 chr19:33592794 A/G cg27124370 chr19:33622961 WDR88 0.45 6.3 0.33 9.74e-10 Bone ultrasound measurement (broadband ultrasound attenuation); CRC cis rs9467711 0.538 rs9467632 chr6:25889706 A/G cg08501292 chr6:25962987 TRIM38 1.11 9.7 0.47 1.03e-19 Autism spectrum disorder or schizophrenia; CRC cis rs853679 0.607 rs13190888 chr6:28285985 G/A cg15845792 chr6:28175446 NA 0.85 5.82 0.31 1.36e-8 Depression; CRC cis rs875971 0.862 rs10224872 chr7:65759773 T/A cg11764359 chr7:65958608 NA -0.61 -9.36 -0.46 1.28e-18 Aortic root size; CRC cis rs3540 1.000 rs3540 chr15:91045408 G/A cg22089800 chr15:90895588 ZNF774 0.48 7.66 0.39 2.11e-13 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; CRC cis rs2932538 0.922 rs34531155 chr1:113141550 C/T cg22162597 chr1:113214053 CAPZA1 0.71 10.05 0.48 6.61e-21 Systolic blood pressure;Diastolic blood pressure;Hypertension;Blood pressure; CRC cis rs6495367 1.000 rs4778882 chr15:79382019 A/G cg17916960 chr15:79447300 NA 0.39 6.31 0.33 9.15e-10 Spherical equivalent (joint analysis main effects and education interaction); CRC cis rs514406 0.861 rs4926576 chr1:53226775 C/T cg08859206 chr1:53392774 SCP2 0.42 6.56 0.34 2.14e-10 Monocyte count; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg24972080 chr11:65154083 FRMD8 0.42 6.91 0.36 2.48e-11 Liver disease severity in Alagille syndrome; CRC cis rs6570726 0.599 rs4398765 chr6:145935006 C/A cg05347473 chr6:146136440 FBXO30 0.48 6.91 0.36 2.48e-11 Lobe attachment (rater-scored or self-reported); CRC cis rs4664293 0.801 rs7590595 chr2:160571709 A/G cg08347373 chr2:160653686 CD302 -0.35 -5.62 -0.3 4.15e-8 Monocyte percentage of white cells; CRC cis rs854765 0.583 rs9912895 chr17:17826020 C/T cg24612305 chr17:17875800 TOM1L2;LRRC48 -0.66 -11.59 -0.54 2.92e-26 Total body bone mineral density; CRC cis rs6951245 1.000 rs11770909 chr7:1086716 G/A cg18402987 chr7:1209562 NA 0.64 6.67 0.35 1.08e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs9649213 0.593 rs62478177 chr7:97964611 G/A cg24562669 chr7:97807699 LMTK2 0.43 7.06 0.36 9.67e-12 Prostate cancer (SNP x SNP interaction); CRC cis rs9287719 0.967 rs6751398 chr2:10738972 T/C cg00105475 chr2:10696890 NA 0.45 7.3 0.37 2.19e-12 Prostate cancer; CRC cis rs6460942 0.908 rs6948654 chr7:12418546 T/A cg20607287 chr7:12443886 VWDE -0.6 -6.94 -0.36 2.14e-11 Coronary artery disease; CRC cis rs6964587 0.743 rs33993294 chr7:91998655 A/C cg17063962 chr7:91808500 NA 0.72 10.7 0.51 3.83e-23 Breast cancer; CRC cis rs6460942 1.000 rs6460936 chr7:12404913 T/C cg06484146 chr7:12443880 VWDE -0.76 -7.66 -0.39 2.09e-13 Coronary artery disease; CRC cis rs763014 0.966 rs4984675 chr16:670117 T/C cg07343612 chr16:622815 PIGQ -0.8 -13.33 -0.59 1.09e-32 Height; CRC cis rs78456975 1.000 rs10192959 chr2:1553393 G/T cg26248373 chr2:1572462 NA -0.66 -7.1 -0.36 7.65e-12 Placebo response in major depressive disorder (% change in symptom score); CRC cis rs2882667 0.858 rs6882112 chr5:138413735 C/T cg09476006 chr5:138032270 NA -0.42 -6.8 -0.35 5.04e-11 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs7617773 0.963 rs12494304 chr3:48178029 C/T cg11946769 chr3:48343235 NME6 -0.45 -6.33 -0.33 8.24e-10 Coronary artery disease; CRC cis rs3096299 0.583 rs2965949 chr16:89520452 A/G cg05320533 chr16:89541815 ANKRD11 -0.45 -6.31 -0.33 9.12e-10 Multiple myeloma (IgH translocation); CRC cis rs9534288 0.912 rs9534297 chr13:46624630 T/C cg15192986 chr13:46630673 CPB2 -0.74 -10.26 -0.49 1.29e-21 Blood protein levels; CRC cis rs6121246 0.529 rs6058196 chr20:30194714 A/T cg13852791 chr20:30311386 BCL2L1 0.6 8.21 0.41 5.04e-15 Mean corpuscular hemoglobin; CRC cis rs10504229 0.906 rs112793785 chr8:58190537 T/C cg24829409 chr8:58192753 C8orf71 -0.68 -11.29 -0.53 3.23e-25 Developmental language disorder (linguistic errors); CRC cis rs898097 0.841 rs4986136 chr17:80865119 A/G cg15369054 chr17:80825471 TBCD -0.55 -8.93 -0.44 2.98e-17 Breast cancer; CRC cis rs1150668 0.796 rs728122 chr6:28399124 G/A cg06470822 chr6:28175283 NA 0.51 7.56 0.38 3.95e-13 Pubertal anthropometrics; CRC cis rs8067545 0.750 rs35003563 chr17:19989218 G/A cg13482628 chr17:19912719 NA 0.47 7.63 0.39 2.58e-13 Schizophrenia; CRC cis rs4731207 0.724 rs6968693 chr7:124549976 C/T cg23710748 chr7:124431027 NA -0.37 -5.98 -0.31 5.75e-9 Cutaneous malignant melanoma; CRC cis rs3736485 0.932 rs11633395 chr15:51917957 G/T cg08986416 chr15:51914746 DMXL2 -0.46 -6.38 -0.33 5.89e-10 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs977987 0.836 rs4888376 chr16:75322573 T/C cg03315344 chr16:75512273 CHST6 0.54 8.95 0.44 2.67e-17 Dupuytren's disease; CRC cis rs7666738 0.830 rs13147195 chr4:98893334 G/T cg17366294 chr4:99064904 C4orf37 0.41 6.72 0.35 8.24e-11 Colonoscopy-negative controls vs population controls; CRC cis rs6665290 0.904 rs1343743 chr1:227183125 C/T cg10327440 chr1:227177885 CDC42BPA -1.04 -22.88 -0.78 5.34e-70 Myeloid white cell count; CRC cis rs4986172 0.690 rs11657325 chr17:43242694 C/T cg10701640 chr17:43249399 NA 0.47 9.78 0.47 5.23e-20 Height; CRC cis rs1046896 0.553 rs72634343 chr17:80827392 T/C cg02711726 chr17:80685570 FN3KRP -0.51 -6.87 -0.35 3.17e-11 Glycated hemoglobin levels; CRC cis rs4862750 0.957 rs2375916 chr4:187903923 A/G cg22105103 chr4:187893119 NA 0.63 10.97 0.52 4.42e-24 Lobe attachment (rater-scored or self-reported); CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg27549887 chr15:48623952 DUT -0.41 -6.18 -0.32 1.91e-9 Myopia (pathological); CRC cis rs853679 0.517 rs17711344 chr6:28077602 A/G cg15786705 chr6:28176104 NA -0.78 -9.96 -0.48 1.35e-20 Depression; CRC cis rs875971 0.660 rs7807930 chr7:66087165 C/T cg18876405 chr7:65276391 NA -0.62 -11.16 -0.52 9.67e-25 Aortic root size; CRC cis rs763121 0.853 rs5750673 chr22:39110124 G/A cg06022373 chr22:39101656 GTPBP1 0.78 12.07 0.55 5.23e-28 Menopause (age at onset); CRC cis rs7274811 0.744 rs3213183 chr20:32262962 C/T cg03904042 chr20:32255491 NECAB3;C20orf134 -0.39 -5.85 -0.31 1.19e-8 Height; CRC trans rs11148252 0.538 rs2296348 chr13:52710136 T/G cg18335740 chr13:41363409 SLC25A15 0.53 7.93 0.4 3.43e-14 Lewy body disease; CRC cis rs6761276 0.868 rs12468224 chr2:113834434 G/C cg09040174 chr2:113837401 NA 0.65 10.3 0.49 9.83e-22 Protein quantitative trait loci; CRC cis rs35110281 0.713 rs6518310 chr21:45098670 T/A cg04455712 chr21:45112962 RRP1B 0.43 8.35 0.42 1.87e-15 Mean corpuscular volume; CRC cis rs2635047 0.542 rs2684814 chr18:44754103 C/T cg19077165 chr18:44547161 KATNAL2 0.39 6.07 0.32 3.48e-9 Educational attainment; CRC cis rs28830936 0.966 rs17678552 chr15:42066190 T/C cg17847044 chr15:42102381 MAPKBP1 -0.31 -6.4 -0.33 5.28e-10 Diastolic blood pressure; CRC cis rs2120019 1.000 rs34237279 chr15:75361121 A/G cg17294928 chr15:75287854 SCAMP5 -0.77 -11.65 -0.54 1.72e-26 Blood trace element (Zn levels); CRC cis rs6968419 0.674 rs4730723 chr7:115904052 T/C cg02561103 chr7:115862891 TES -0.43 -6.5 -0.34 2.92e-10 Intraocular pressure; CRC cis rs9297145 0.678 rs62473048 chr7:98775511 T/C cg05967295 chr7:98741636 SMURF1 1.12 17.4 0.69 1.6e-48 Crohn's disease;Inflammatory bowel disease;Ulcerative colitis; CRC cis rs8062405 0.755 rs4788078 chr16:28559981 G/A cg05139728 chr16:28306816 SBK1 -0.37 -5.99 -0.31 5.4e-9 Cognitive ability (multi-trait analysis);Cognitive ability; CRC cis rs7811142 0.830 rs73401451 chr7:99981895 T/C cg00814883 chr7:100076585 TSC22D4 -0.68 -8.54 -0.43 4.97e-16 Platelet count; CRC cis rs6942756 1.000 rs66970518 chr7:128871006 G/A cg02491457 chr7:128862824 NA -0.74 -10.14 -0.49 3.45e-21 White matter hyperintensity burden; CRC cis rs873946 0.648 rs1543593 chr10:134553185 A/T cg06453172 chr10:134556979 INPP5A -0.71 -8.73 -0.43 1.33e-16 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CRC trans rs587242 1.000 rs4341405 chr1:96902589 A/G cg10631902 chr5:14652156 NA 0.44 6.84 0.35 3.84e-11 Body mass index (joint analysis main effects and physical activity interaction);Body mass index in physically inactive individuals;Body mass index; CRC cis rs262150 0.630 rs2730274 chr7:158796062 C/A cg12590608 chr7:158785262 NA 0.38 6.46 0.34 3.84e-10 Facial morphology (factor 20); CRC cis rs651907 0.557 rs11917569 chr3:101355063 G/C cg12386194 chr3:101231763 SENP7 0.48 6.86 0.35 3.45e-11 Colorectal cancer; CRC cis rs8060686 0.641 rs113704872 chr16:68032598 G/A cg26727032 chr16:67993705 SLC12A4 -0.58 -6.39 -0.33 5.67e-10 HDL cholesterol;Metabolic syndrome; CRC trans rs7301826 0.627 rs7315707 chr12:131272819 A/G cg13009927 chr2:242254519 SEPT2;HDLBP 0.47 5.96 0.31 6.53e-9 Plasma plasminogen activator levels; CRC cis rs2976388 0.590 rs4736322 chr8:143822208 T/C cg20041105 chr8:143859282 LYNX1 -0.41 -6.79 -0.35 5.23e-11 Urinary tract infection frequency; CRC trans rs35110281 0.782 rs2246602 chr21:45064296 C/A cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.5 8.49 0.42 7.06e-16 Mean corpuscular volume; CRC cis rs1008375 0.966 rs4515155 chr4:17696477 G/T cg16339924 chr4:17578868 LAP3 0.49 6.63 0.34 1.39e-10 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs7191439 0.674 rs4782429 chr16:88792097 A/G cg02389323 chr16:88786976 FAM38A 0.89 8.63 0.43 2.75e-16 Plateletcrit; CRC cis rs7613875 0.600 rs2624826 chr3:50155468 T/G cg24308560 chr3:49941425 MST1R 0.4 6.01 0.31 5.01e-9 Body mass index; CRC cis rs826838 1.000 rs11168367 chr12:38913397 T/G cg13010199 chr12:38710504 ALG10B 0.47 6.04 0.32 4.08e-9 Heart rate; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg03672602 chr19:19754555 GMIP 0.48 6.71 0.35 8.64e-11 Response to antipsychotic treatment; CRC cis rs9322193 0.923 rs10872649 chr6:150080590 T/G cg05861140 chr6:150128134 PCMT1 -0.39 -6.26 -0.33 1.21e-9 Lung cancer; CRC cis rs1005277 0.541 rs2472177 chr10:38384015 T/G cg00409905 chr10:38381863 ZNF37A -0.66 -11.28 -0.53 3.64e-25 Extrinsic epigenetic age acceleration; CRC cis rs853679 0.517 rs9393896 chr6:28127703 C/T cg03623178 chr6:28175578 NA 0.98 12.66 0.57 3.31e-30 Depression; CRC cis rs1707322 0.964 rs796773 chr1:46564475 C/T cg06784218 chr1:46089804 CCDC17 -0.55 -9.67 -0.47 1.26e-19 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs9858542 1.000 rs34762726 chr3:49689210 G/A cg07274523 chr3:49395745 GPX1 0.46 5.96 0.31 6.45e-9 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs9487051 0.734 rs56214745 chr6:109536748 G/T cg01475377 chr6:109611718 NA -0.33 -5.61 -0.3 4.36e-8 Reticulocyte fraction of red cells; CRC trans rs10411161 0.702 rs1433081 chr19:52390710 A/C cg22319618 chr22:45562946 NUP50 -0.58 -6.09 -0.32 3.22e-9 Breast cancer; CRC cis rs1499614 1.000 rs2707830 chr7:66167645 T/C cg12463550 chr7:65579703 CRCP 0.64 5.79 0.3 1.66e-8 Gout; CRC cis rs3772130 0.962 rs13433692 chr3:121484714 G/T cg20356878 chr3:121714668 ILDR1 0.51 7.9 0.4 4.1e-14 Cognitive performance; CRC cis rs4819052 0.807 rs7283915 chr21:46671288 T/C cg11663144 chr21:46675770 NA -0.83 -14.35 -0.62 1.38e-36 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs539096 0.566 rs3011220 chr1:44308867 A/G cg12908607 chr1:44402522 ARTN -0.55 -10.12 -0.49 3.81e-21 Intelligence (multi-trait analysis); CRC cis rs9393692 0.967 rs6456712 chr6:26302573 A/C cg00631329 chr6:26305371 NA -0.69 -12.89 -0.58 4.51e-31 Educational attainment; CRC cis rs1949733 0.523 rs62287455 chr4:8544994 A/T cg11789530 chr4:8429930 ACOX3 -0.56 -7.71 -0.39 1.46e-13 Response to antineoplastic agents; CRC cis rs9311474 0.507 rs4687644 chr3:52746541 T/G cg18404041 chr3:52824283 ITIH1 -0.4 -8.28 -0.42 3.21e-15 Electroencephalogram traits; CRC cis rs7493 0.755 rs13223537 chr7:94966167 C/T cg21856205 chr7:94953877 PON1 0.44 5.78 0.3 1.74e-8 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs1448094 0.512 rs60986162 chr12:86247054 T/G cg18827107 chr12:86230957 RASSF9 -0.45 -7.49 -0.38 6.6e-13 Major depressive disorder; CRC trans rs853679 1.000 rs7740487 chr6:28216486 C/G cg06606381 chr12:133084897 FBRSL1 -0.74 -7.05 -0.36 1.08e-11 Depression; CRC cis rs11608355 0.515 rs4766609 chr12:109973297 A/G cg05360138 chr12:110035743 NA 0.76 8.66 0.43 2.15e-16 Neuroticism; CRC cis rs10504229 0.683 rs72650849 chr8:58140323 A/G cg04204079 chr8:58130323 NA -0.45 -5.78 -0.3 1.71e-8 Developmental language disorder (linguistic errors); CRC cis rs4664308 0.967 rs62175559 chr2:160955833 G/A cg03641300 chr2:160917029 PLA2R1 -0.74 -12.19 -0.56 1.88e-28 Idiopathic membranous nephropathy; CRC cis rs2836974 0.602 rs8130854 chr21:40707041 G/A cg11644478 chr21:40555479 PSMG1 -0.64 -9.86 -0.48 3.01e-20 Cognitive function; CRC cis rs7086627 0.515 rs11202959 chr10:82209672 A/G cg00277334 chr10:82204260 NA -0.84 -16.95 -0.68 9.58e-47 Post bronchodilator FEV1; CRC cis rs703980 0.565 rs703970 chr10:80953136 A/C cg20744163 chr10:80999841 ZMIZ1 0.33 5.89 0.31 9.73e-9 Type 2 diabetes; CRC cis rs6502050 0.871 rs8072702 chr17:80074280 C/T cg19223190 chr17:80058835 NA -0.41 -6.53 -0.34 2.42e-10 Life satisfaction; CRC cis rs651907 0.535 rs34063583 chr3:101509948 C/T cg11279151 chr3:101281821 RG9MTD1 -0.53 -7.08 -0.36 8.95e-12 Colorectal cancer; CRC cis rs870825 0.929 rs72689262 chr4:185590950 C/G cg07424746 chr4:185654737 MLF1IP -0.59 -5.82 -0.31 1.4e-8 Blood protein levels; CRC cis rs600231 0.508 rs35292734 chr11:65227700 C/T cg17120908 chr11:65337727 SSSCA1 -0.71 -7.71 -0.39 1.54e-13 Bone mineral density; CRC cis rs2073300 0.609 rs6132615 chr20:23413200 T/C cg12062639 chr20:23401060 NAPB 0.84 7.67 0.39 2.02e-13 Peripheral arterial disease (traffic-related air pollution interaction); CRC trans rs208520 1.000 rs12192261 chr6:66985268 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.88 10.79 0.51 1.94e-23 Exhaled nitric oxide output; CRC cis rs6502050 0.835 rs4789677 chr17:80119842 A/G cg22110888 chr17:80059540 CCDC57 0.4 6.38 0.33 5.96e-10 Life satisfaction; CRC cis rs4654899 0.680 rs10916900 chr1:21239059 C/G cg02927042 chr1:21476669 EIF4G3 -0.4 -6.2 -0.32 1.71e-9 Superior frontal gyrus grey matter volume; CRC cis rs875971 0.662 rs448725 chr7:65514628 A/G cg18912574 chr7:65842487 NCRNA00174 0.37 6.47 0.34 3.56e-10 Aortic root size; CRC trans rs208520 0.661 rs6937856 chr6:66867468 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.05 -14.8 -0.63 2.42e-38 Exhaled nitric oxide output; CRC cis rs9463078 0.845 rs9349315 chr6:45172289 A/G cg25276700 chr6:44698697 NA -0.28 -6.75 -0.35 6.58e-11 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; CRC cis rs2153535 0.580 rs4960421 chr6:8459292 C/T cg07606381 chr6:8435919 SLC35B3 0.69 11.15 0.52 1.04e-24 Motion sickness; CRC cis rs6598955 0.694 rs6659387 chr1:26634307 G/A cg04990556 chr1:26633338 UBXN11 -0.77 -12.79 -0.58 1.15e-30 Obesity-related traits; CRC cis rs9467160 1.000 rs9461010 chr6:24440206 T/C cg16211469 chr6:24423932 MRS2 0.37 5.79 0.3 1.64e-8 Liver enzyme levels; CRC cis rs12545109 0.732 rs1973629 chr8:57429583 A/G cg09654669 chr8:57350985 NA -0.43 -5.7 -0.3 2.69e-8 Obesity-related traits; CRC cis rs9902453 0.765 rs2729448 chr17:28091953 T/C cg26525008 chr17:28256777 EFCAB5;SSH2 -0.72 -12.09 -0.55 4.14e-28 Coffee consumption (cups per day); CRC cis rs11577318 0.853 rs12728971 chr1:26626612 C/T cg00852783 chr1:26633632 UBXN11 0.47 6.76 0.35 6.21e-11 Granulocyte percentage of myeloid white cells; CRC cis rs28830936 1.000 rs17678138 chr15:42043067 G/A cg17847044 chr15:42102381 MAPKBP1 -0.29 -6.34 -0.33 7.72e-10 Diastolic blood pressure; CRC cis rs694739 0.964 rs2510066 chr11:64052447 C/T cg02228329 chr11:64053129 BAD;GPR137 0.62 9.16 0.45 5.83e-18 Alopecia areata;Crohn's disease;Psoriasis vulgaris; CRC cis rs1799949 0.965 rs4793234 chr17:41436183 A/G cg01879757 chr17:41196368 BRCA1 -0.44 -6.58 -0.34 1.81e-10 Menopause (age at onset); CRC cis rs875971 0.520 rs12666485 chr7:65625122 T/C cg18876405 chr7:65276391 NA 0.44 6.12 0.32 2.67e-9 Aortic root size; CRC trans rs3808502 0.503 rs2061830 chr8:11397457 C/G cg16141378 chr3:129829833 LOC729375 -0.46 -6.78 -0.35 5.43e-11 Neuroticism; CRC cis rs2282802 0.685 rs10077671 chr5:139689505 C/T cg26211634 chr5:139558579 C5orf32 0.44 7.75 0.39 1.18e-13 Intelligence (multi-trait analysis); CRC cis rs4363385 0.693 rs581447 chr1:153033269 A/G cg25856811 chr1:152973957 SPRR3 -0.24 -6.6 -0.34 1.62e-10 Inflammatory skin disease; CRC cis rs10504229 1.000 rs66495524 chr8:58187365 C/T cg02725872 chr8:58115012 NA -0.38 -6.43 -0.33 4.44e-10 Developmental language disorder (linguistic errors); CRC cis rs644799 0.562 rs669973 chr11:95571839 A/G cg03916912 chr11:95522834 CEP57;FAM76B 0.7 11.6 0.54 2.63e-26 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs6809651 0.524 rs56940353 chr3:185798296 T/C cg00760338 chr3:185826511 ETV5 -0.71 -9.22 -0.45 3.61e-18 Body mass index in physically active individuals;Glomerular filtration rate (creatinine);Body mass index (joint analysis main effects and physical activity interaction);Body mass index;Body mass index in physically inactive individuals; CRC cis rs9768139 0.611 rs12698211 chr7:158119623 G/A cg24154853 chr7:158122151 PTPRN2 0.64 10.59 0.5 9.21e-23 Calcium levels; CRC cis rs7264396 0.747 rs2425151 chr20:34394541 C/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.6 -10.47 -0.5 2.42e-22 Total cholesterol levels; CRC cis rs11123170 0.650 rs2289897 chr2:113977454 G/A cg11763394 chr2:113992921 PAX8;LOC440839;LOC654433 0.59 7.16 0.37 5.45e-12 Renal function-related traits (BUN); CRC cis rs13108904 0.870 rs4974542 chr4:1250908 A/G cg21620606 chr4:1342894 KIAA1530 0.4 6.94 0.36 2.06e-11 Obesity-related traits; CRC cis rs936229 0.861 rs7176022 chr15:75107880 G/T cg10253484 chr15:75165896 SCAMP2 0.41 6.14 0.32 2.39e-9 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); CRC cis rs12760731 0.720 rs12035174 chr1:178314311 A/T cg00404053 chr1:178313656 RASAL2 0.92 9.61 0.47 1.96e-19 Obesity-related traits; CRC cis rs4073582 0.595 rs10896104 chr11:66001869 C/T cg16950941 chr11:66035639 RAB1B 0.71 12.15 0.56 2.57e-28 Gout; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg08077726 chr17:74734280 SFRS2;MFSD11 0.47 6.49 0.34 3.08e-10 Response to antipsychotic treatment; CRC cis rs1003719 0.788 rs4817844 chr21:38447064 A/T cg10648535 chr21:38446584 PIGP;TTC3 -0.52 -7.47 -0.38 7.1e-13 Eye color traits; CRC cis rs7584330 0.554 rs6744807 chr2:238424684 A/G cg14458575 chr2:238380390 NA 0.42 6.11 0.32 2.87e-9 Prostate cancer; CRC cis rs11971779 0.680 rs11772026 chr7:139052589 T/G cg23387468 chr7:139079360 LUC7L2 0.41 7.04 0.36 1.14e-11 Diisocyanate-induced asthma; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg08017156 chr16:21611107 METTL9 0.49 6.81 0.35 4.54e-11 Response to antipsychotic treatment; CRC cis rs7493 1.000 rs2299265 chr7:95048870 C/G cg19678392 chr7:94953810 PON1 -0.59 -7.36 -0.38 1.49e-12 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs1448094 0.556 rs4897831 chr12:86168248 C/T cg25456477 chr12:86230367 RASSF9 0.4 6.76 0.35 6.23e-11 Major depressive disorder; CRC cis rs13082711 0.911 rs2887926 chr3:27494475 T/C cg02860705 chr3:27208620 NA 0.61 8.71 0.43 1.46e-16 Systolic blood pressure;Diastolic blood pressure;Blood pressure; CRC cis rs5769765 0.773 rs11090920 chr22:50320105 A/G cg22709217 chr22:50311962 ALG12;CRELD2 -0.97 -13.1 -0.59 7.73e-32 Schizophrenia; CRC cis rs12313068 0.709 rs11064912 chr12:110505699 A/T cg12870014 chr12:110450643 ANKRD13A -0.89 -14.89 -0.63 1.07e-38 Intelligence (multi-trait analysis); CRC cis rs1577917 0.560 rs12193777 chr6:86246709 C/A cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A 0.49 6.94 0.36 2.06e-11 Response to antipsychotic treatment; CRC cis rs1577917 0.958 rs2324840 chr6:86557620 T/A cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.5 -6.48 -0.34 3.33e-10 Response to antipsychotic treatment; CRC cis rs9903692 0.954 rs2240122 chr17:46152559 C/A cg21215337 chr17:46176117 CBX1 0.42 7.79 0.39 8.7e-14 Pulse pressure; CRC cis rs916888 0.773 rs199533 chr17:44828931 G/A cg17911788 chr17:44343683 NA -0.66 -7.28 -0.37 2.55e-12 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs11864453 0.647 rs10492814 chr16:72126514 G/A cg23815491 chr16:72088622 HP 0.51 7.65 0.39 2.3e-13 Fibrinogen levels; CRC cis rs8114671 0.562 rs6088636 chr20:33469746 C/T cg07148914 chr20:33460835 GGT7 0.38 6.41 0.33 5.12e-10 Height; CRC cis rs870825 0.616 rs7660939 chr4:185640792 T/C cg04058563 chr4:185651563 MLF1IP 0.73 9.54 0.47 3.32e-19 Blood protein levels; CRC cis rs853679 0.882 rs4713140 chr6:28097193 C/T cg06470822 chr6:28175283 NA 0.77 6.26 0.33 1.19e-9 Depression; CRC cis rs13108904 0.539 rs13135102 chr4:1330983 A/C cg02018176 chr4:1364513 KIAA1530 0.4 5.92 0.31 8.2e-9 Obesity-related traits; CRC trans rs1997103 1.000 rs2177805 chr7:55404381 T/A cg20935933 chr6:143382018 AIG1 0.51 6.68 0.35 1.03e-10 QRS interval (sulfonylurea treatment interaction); CRC cis rs3820068 0.603 rs2236215 chr1:15892415 A/C cg27534772 chr1:16042836 PLEKHM2 0.51 9.45 0.46 6.71e-19 Systolic blood pressure; CRC cis rs3858526 0.514 rs4595572 chr11:5864045 T/G cg05234568 chr11:5960015 NA -0.74 -12.53 -0.57 1.01e-29 DNA methylation (variation); CRC cis rs17376456 0.825 rs17372057 chr5:93071916 C/A cg25358565 chr5:93447407 FAM172A 0.96 9.42 0.46 8.02e-19 Diabetic retinopathy; CRC cis rs9911578 0.900 rs4793593 chr17:56892699 C/G cg12560992 chr17:57184187 TRIM37 -0.91 -16.33 -0.67 2.52e-44 Intelligence (multi-trait analysis); CRC cis rs661713 0.734 rs618371 chr6:90978829 G/A cg06866423 chr6:90926672 BACH2 0.38 5.71 0.3 2.56e-8 Hypothyroidism; CRC cis rs12497850 0.931 rs13064784 chr3:49135961 C/G cg07636037 chr3:49044803 WDR6 0.97 16.56 0.67 3.23e-45 Parkinson's disease; CRC cis rs317689 0.918 rs581911 chr12:69738293 C/T cg20891283 chr12:69753455 YEATS4 0.62 8.0 0.4 2.19e-14 Response to diuretic therapy; CRC cis rs9814567 0.964 rs9841180 chr3:134191880 C/G cg06109529 chr3:134205091 CEP63;ANAPC13 -0.8 -11.49 -0.54 6.33e-26 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs6840360 0.642 rs2709842 chr4:152370637 C/T cg09659197 chr4:152720779 NA -0.33 -6.43 -0.33 4.55e-10 Intelligence (multi-trait analysis); CRC cis rs947211 0.950 rs1775145 chr1:205756143 C/A cg11965913 chr1:205819406 PM20D1 0.47 6.59 0.34 1.71e-10 Parkinson's disease; CRC trans rs703108 0.731 rs7898954 chr10:22323646 A/G cg21396487 chr1:173793343 CENPL;DARS2 -0.46 -5.99 -0.31 5.61e-9 Monocyte percentage of white cells; CRC cis rs9322193 0.962 rs10872653 chr6:150100043 A/C cg00933542 chr6:150070202 PCMT1 0.28 5.63 0.3 3.86e-8 Lung cancer; CRC cis rs7927771 0.832 rs1317164 chr11:47419757 G/T cg05585544 chr11:47624801 NA -0.54 -9.63 -0.47 1.65e-19 Subjective well-being; CRC cis rs10504229 0.683 rs2005392 chr8:58106896 T/C cg21724239 chr8:58056113 NA 0.52 6.99 0.36 1.58e-11 Developmental language disorder (linguistic errors); CRC cis rs13098911 0.540 rs9825081 chr3:46108400 G/A cg12691230 chr3:46064611 XCR1 -0.53 -6.09 -0.32 3.17e-9 Celiac disease; CRC cis rs12802200 0.535 rs12282299 chr11:570009 T/C cg16486109 chr11:613632 IRF7 0.59 10.3 0.49 9.34e-22 Systemic lupus erythematosus; CRC cis rs3008870 1.000 rs2815352 chr1:67482104 A/G cg08660285 chr1:67390436 MIER1;WDR78 1.04 15.31 0.64 2.58e-40 Lymphocyte percentage of white cells; CRC cis rs4481887 0.893 rs10888355 chr1:248457180 G/A cg13385794 chr1:248469461 NA 0.39 6.99 0.36 1.52e-11 Common traits (Other); CRC cis rs35000415 0.938 rs35234849 chr7:128648953 T/C cg19972273 chr7:128594194 NA 0.68 6.31 0.33 8.75e-10 Systemic lupus erythematosus; CRC cis rs2836950 0.501 rs2836984 chr21:40700949 A/C cg11644478 chr21:40555479 PSMG1 -0.46 -6.75 -0.35 6.74e-11 Menarche (age at onset); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg10735211 chr4:4310922 ZNF509 -0.39 -6.16 -0.32 2.13e-9 Liver disease severity in Alagille syndrome; CRC cis rs17023223 0.581 rs10923750 chr1:119650795 T/G cg05756136 chr1:119680316 WARS2 -0.52 -6.87 -0.35 3.25e-11 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for BMI in active individuals; CRC cis rs1044826 0.647 rs4683463 chr3:139196946 T/G cg00490450 chr3:139108681 COPB2 0.44 6.47 0.34 3.52e-10 Obesity-related traits; CRC cis rs12762955 0.519 rs7094331 chr10:1022816 T/C cg19847866 chr10:1019161 NA 0.39 5.84 0.31 1.22e-8 Response to angiotensin II receptor blocker therapy; CRC cis rs12701220 0.541 rs12535516 chr7:1114440 C/G cg02733842 chr7:1102375 C7orf50 -0.91 -12.31 -0.56 6.67e-29 Bronchopulmonary dysplasia; CRC cis rs873946 0.648 rs12783354 chr10:134557235 T/A cg27286337 chr10:134555280 INPP5A 0.84 10.25 0.49 1.42e-21 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CRC cis rs4588572 0.601 rs10942855 chr5:77737529 G/A cg11446398 chr5:77624930 NA 0.46 6.1 0.32 3.01e-9 Triglycerides; CRC cis rs6121246 0.529 rs6058196 chr20:30194714 A/T cg18721089 chr20:30220636 NA -0.52 -7.93 -0.4 3.54e-14 Mean corpuscular hemoglobin; CRC cis rs4563143 0.675 rs73029049 chr19:29275534 C/A cg12756686 chr19:29218302 NA 0.61 9.07 0.45 1.08e-17 Methadone dose in opioid dependence; CRC cis rs1881396 0.783 rs10181342 chr2:27757343 A/G cg27432699 chr2:27873401 GPN1 0.65 8.57 0.43 4.1e-16 Nonalcoholic fatty liver disease; CRC cis rs12900413 0.687 rs11629590 chr15:90304644 A/G cg24249390 chr15:90295951 MESP1 0.56 8.64 0.43 2.56e-16 Coronary artery aneurysm in Kawasaki disease; CRC cis rs4862750 0.872 rs6825289 chr4:187879109 T/G cg07414643 chr4:187882934 NA 0.39 6.82 0.35 4.47e-11 Lobe attachment (rater-scored or self-reported); CRC cis rs35849525 0.776 rs7615318 chr3:49987475 C/T cg05623727 chr3:50126028 RBM5 0.53 6.97 0.36 1.71e-11 Intelligence (multi-trait analysis); CRC cis rs7584330 0.554 rs10176035 chr2:238433449 T/C cg14458575 chr2:238380390 NA 0.53 7.01 0.36 1.36e-11 Prostate cancer; CRC cis rs7973719 0.868 rs7315553 chr12:7353838 A/C cg07052231 chr12:7363540 PEX5 0.52 8.34 0.42 2.01e-15 IgG glycosylation; CRC cis rs7811142 1.000 rs6962151 chr7:100028484 T/C cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.76 10.89 0.51 8.98e-24 Platelet count; CRC trans rs1728785 1.000 rs1645936 chr16:68563743 A/G cg04657470 chr2:198365150 HSPE1;HSPD1 0.57 6.92 0.36 2.33e-11 Ulcerative colitis; CRC cis rs4731207 0.596 rs10226659 chr7:124609868 A/C cg23710748 chr7:124431027 NA -0.39 -6.25 -0.33 1.29e-9 Cutaneous malignant melanoma; CRC cis rs7264396 0.887 rs224363 chr20:34062710 C/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.42 -6.95 -0.36 2.01e-11 Total cholesterol levels; CRC cis rs6461049 0.765 rs4719431 chr7:2140312 T/C cg08027265 chr7:2291960 NA -0.37 -6.44 -0.33 4.31e-10 Schizophrenia; CRC cis rs282587 0.569 rs282600 chr13:113391602 G/A cg04656015 chr13:113407548 ATP11A 0.63 7.97 0.4 2.62e-14 Glycated hemoglobin levels; CRC cis rs6088590 1.000 rs2295354 chr20:33356541 T/C cg08999081 chr20:33150536 PIGU 0.5 8.44 0.42 1e-15 Coronary artery disease; CRC trans rs1814175 0.817 rs10769641 chr11:49960141 A/G cg21153622 chr11:89784906 NA -0.37 -6.03 -0.32 4.33e-9 Height; CRC cis rs10504229 1.000 rs77120900 chr8:58170368 C/T cg01721255 chr8:58191610 C8orf71 0.49 6.17 0.32 2e-9 Developmental language disorder (linguistic errors); CRC cis rs9818758 0.556 rs11716614 chr3:49017208 C/G cg07636037 chr3:49044803 WDR6 -0.84 -6.02 -0.32 4.57e-9 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; CRC cis rs2952156 0.883 rs8077172 chr17:37834977 G/T cg20243544 chr17:37824526 PNMT 0.55 8.95 0.44 2.66e-17 Asthma; CRC cis rs7208859 0.673 rs11656845 chr17:29206164 G/T cg01831904 chr17:28903510 LRRC37B2 -0.54 -5.69 -0.3 2.86e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC trans rs9291683 0.588 rs3756237 chr4:10013378 G/A cg26043149 chr18:55253948 FECH 0.51 7.91 0.4 3.95e-14 Bone mineral density; CRC cis rs67311347 0.956 rs12633446 chr3:40505661 G/A cg24209194 chr3:40518798 ZNF619 -0.44 -6.79 -0.35 5.28e-11 Renal cell carcinoma; CRC cis rs9611565 0.729 rs169362 chr22:41827589 G/C cg06634786 chr22:41940651 POLR3H 0.45 5.63 0.3 3.92e-8 Vitiligo; CRC trans rs7395662 0.824 rs4882180 chr11:48749357 C/A cg21153622 chr11:89784906 NA -0.47 -7.48 -0.38 7.01e-13 HDL cholesterol; CRC cis rs1983170 0.736 rs11164909 chr1:92002506 T/C cg21854759 chr1:92012499 NA 0.51 6.05 0.32 3.99e-9 Eosinophil percentage of white cells; CRC cis rs4713118 0.955 rs34752872 chr6:27683244 A/T cg15786705 chr6:28176104 NA 0.49 6.44 0.33 4.26e-10 Parkinson's disease; CRC cis rs1008375 1.000 rs7697889 chr4:17617961 G/T cg04450456 chr4:17643702 FAM184B 0.35 5.73 0.3 2.21e-8 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs13191362 0.935 rs67337490 chr6:162953961 G/A cg06582575 chr6:163149167 PACRG;PARK2 0.8 9.93 0.48 1.71e-20 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC trans rs459571 0.916 rs467303 chr9:136904835 C/T cg09836344 chr4:1243392 C4orf42;CTBP1 -0.81 -11.28 -0.53 3.65e-25 Platelet distribution width; CRC cis rs7746199 0.668 rs34864796 chr6:27459923 G/A cg15845792 chr6:28175446 NA 0.77 6.2 0.32 1.67e-9 Gait speed in old age;Autism spectrum disorder or schizophrenia; CRC cis rs67311347 1.000 rs56992941 chr3:40472434 A/T cg24209194 chr3:40518798 ZNF619 0.45 6.84 0.35 3.85e-11 Renal cell carcinoma; CRC cis rs709400 0.658 rs72708874 chr14:103899251 T/G cg12935359 chr14:103987150 CKB -0.52 -7.96 -0.4 2.89e-14 Body mass index; CRC cis rs7072216 0.621 rs3750604 chr10:100175581 G/A cg26618903 chr10:100175079 PYROXD2 -0.48 -7.13 -0.37 6.36e-12 Metabolite levels; CRC cis rs4713118 0.955 rs9380011 chr6:27683924 A/G cg12273811 chr6:28175739 NA 0.51 6.99 0.36 1.49e-11 Parkinson's disease; CRC cis rs7715806 0.500 rs17649248 chr5:74998426 C/T cg19683494 chr5:74908142 NA 0.58 6.45 0.34 3.96e-10 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs4242434 0.672 rs4615566 chr8:22520682 T/C cg03733263 chr8:22462867 KIAA1967 -0.8 -13.93 -0.61 5.27e-35 Exploratory eye movement dysfunction in schizophrenia (cognitive search score); CRC trans rs28735056 0.904 rs62103174 chr18:77621048 A/G cg03973167 chr4:185394988 IRF2 -0.43 -6.12 -0.32 2.64e-9 Schizophrenia; CRC cis rs6121246 0.609 rs2149281 chr20:30417918 G/A cg13852791 chr20:30311386 BCL2L1 0.74 14.75 0.63 3.71e-38 Mean corpuscular hemoglobin; CRC cis rs61656020 1 rs61656020 chr16:1882221 C/G cg14074117 chr16:1909714 C16orf73 0.46 6.79 0.35 5.13e-11 Ankle injury; CRC cis rs6860806 0.507 rs272878 chr5:131671769 C/T cg11843238 chr5:131593191 PDLIM4 -0.45 -7.83 -0.4 6.72e-14 Breast cancer; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg04844016 chr2:65659148 SPRED2 0.54 6.96 0.36 1.85e-11 Thyroid stimulating hormone; CRC cis rs514406 0.708 rs546334 chr1:53326210 T/C cg27535305 chr1:53392650 SCP2 -0.43 -7.77 -0.39 9.9e-14 Monocyte count; CRC cis rs5769765 0.862 rs138857 chr22:50199589 C/T cg22709217 chr22:50311962 ALG12;CRELD2 -0.82 -11.24 -0.53 4.89e-25 Schizophrenia; CRC cis rs1267303 0.642 rs6670699 chr1:46997270 C/T cg25110126 chr1:46999211 NA 0.59 8.42 0.42 1.17e-15 Monobrow; CRC cis rs10504229 0.639 rs35527749 chr8:58128077 G/T cg02725872 chr8:58115012 NA -0.58 -8.11 -0.41 1.03e-14 Developmental language disorder (linguistic errors); CRC cis rs7289126 1.000 rs5995558 chr22:38647639 A/G cg25457927 chr22:38595422 NA -0.33 -6.38 -0.33 6.13e-10 Mammographic density (dense area);Percent mammographic density; CRC cis rs9611565 0.592 rs4822040 chr22:41963553 C/G cg03806693 chr22:41940476 POLR3H -0.83 -10.33 -0.5 7.3e-22 Vitiligo; CRC cis rs6456156 0.586 rs10946209 chr6:167480991 G/A cg07741184 chr6:167504864 NA 0.4 6.88 0.35 3.05e-11 Primary biliary cholangitis; CRC trans rs17641971 0.662 rs1828495 chr8:49945281 C/T cg18784943 chr17:79371681 NA -0.38 -6.11 -0.32 2.84e-9 Blood metabolite levels; CRC cis rs7044106 0.762 rs10760112 chr9:123467570 C/T cg09419670 chr9:123605666 PSMD5;LOC253039 0.7 11.5 0.54 5.97e-26 Hip circumference adjusted for BMI; CRC cis rs12024301 0.557 rs7531622 chr1:183644870 G/A cg11505048 chr1:183622726 RGL1;APOBEC4 0.76 6.85 0.35 3.67e-11 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs40363 0.951 rs250632 chr16:3523047 C/T cg00484396 chr16:3507460 NAT15 0.72 8.21 0.41 5.19e-15 Tuberculosis; CRC cis rs9816226 0.938 rs73052046 chr3:185832414 C/T cg00760338 chr3:185826511 ETV5 -0.7 -7.3 -0.37 2.24e-12 Obesity;Body mass index; CRC cis rs7584330 0.868 rs67071074 chr2:238395429 T/C cg11271282 chr2:238384023 NA 0.47 6.08 0.32 3.26e-9 Prostate cancer; CRC cis rs12540874 0.670 rs3887826 chr7:50544961 G/A cg18232548 chr7:50535776 DDC -0.55 -8.34 -0.42 2.03e-15 Systemic sclerosis; CRC cis rs898097 0.841 rs8180 chr17:80901036 C/G cg15664640 chr17:80829946 TBCD 0.63 10.14 0.49 3.2e-21 Breast cancer; CRC cis rs6502050 0.769 rs8068708 chr17:80120424 T/C cg13198984 chr17:80129470 CCDC57 0.47 8.27 0.41 3.34e-15 Life satisfaction; CRC cis rs34779708 0.733 rs3853672 chr10:35549606 A/C cg03585969 chr10:35415529 CREM 0.5 6.52 0.34 2.66e-10 Inflammatory bowel disease;Crohn's disease; CRC cis rs7845219 0.525 rs6471501 chr8:95922491 A/G cg16049864 chr8:95962084 TP53INP1 -0.45 -6.76 -0.35 6.24e-11 Type 2 diabetes; CRC cis rs2019137 0.560 rs6707386 chr2:113981022 G/A cg11763394 chr2:113992921 PAX8;LOC440839;LOC654433 0.68 10.34 0.5 6.86e-22 Lymphocyte counts; CRC cis rs13108904 0.967 rs13109112 chr4:1290481 C/A cg16405210 chr4:1374714 KIAA1530 -0.44 -6.0 -0.31 5.22e-9 Obesity-related traits; CRC trans rs62295889 0.602 rs58048371 chr4:12538150 T/C cg03490839 chr16:73082051 ZFHX3 0.58 6.06 0.32 3.82e-9 Obesity-related traits; CRC cis rs10493773 0.618 rs17394091 chr1:86075098 A/G cg17807903 chr1:86174739 ZNHIT6 -0.45 -8.23 -0.41 4.56e-15 Urate levels in overweight individuals; CRC cis rs11112613 0.713 rs12316204 chr12:105944244 G/A cg03607813 chr12:105948248 NA 0.81 10.71 0.51 3.6e-23 Corrected insulin response;Corrected insulin response adjusted for insulin sensitivity index; CRC cis rs861020 0.630 rs686582 chr1:210008673 A/C cg05527609 chr1:210001259 C1orf107 0.77 10.91 0.52 7.19e-24 Orofacial clefts; CRC trans rs9929218 0.954 rs2961 chr16:68818903 T/C cg04657470 chr2:198365150 HSPE1;HSPD1 -0.8 -11.19 -0.53 7.33e-25 Colorectal cancer; CRC cis rs6120849 0.901 rs11696967 chr20:33743609 A/C cg24642439 chr20:33292090 TP53INP2 0.43 5.61 0.3 4.36e-8 Protein C levels; CRC cis rs3540 0.512 rs3862433 chr15:91076028 G/A cg22089800 chr15:90895588 ZNF774 -0.58 -9.56 -0.47 2.86e-19 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; CRC cis rs514406 0.792 rs481440 chr1:53344976 C/T cg24675658 chr1:53192096 ZYG11B -0.69 -10.33 -0.49 7.62e-22 Monocyte count; CRC cis rs344364 0.511 rs56077812 chr16:1948870 T/G cg14074117 chr16:1909714 C16orf73 0.41 5.66 0.3 3.28e-8 Glomerular filtration rate in chronic kidney disease; CRC cis rs801193 0.569 rs6951302 chr7:66132512 T/C cg18876405 chr7:65276391 NA -0.5 -8.05 -0.41 1.5e-14 Aortic root size; CRC trans rs7267979 0.934 rs2261115 chr20:25259807 G/A cg17903999 chr18:56338584 MALT1 -0.41 -6.71 -0.35 8.6e-11 Liver enzyme levels (alkaline phosphatase); CRC cis rs7618915 0.547 rs11709448 chr3:52647449 T/C cg05573699 chr3:52720067 GNL3;PBRM1 -0.44 -6.26 -0.33 1.18e-9 Bipolar disorder; CRC cis rs875971 0.660 rs13224319 chr7:66007363 A/G cg25985355 chr7:65971099 NA -0.32 -5.78 -0.3 1.75e-8 Aortic root size; CRC cis rs75422866 0.510 rs73105814 chr12:48119600 C/G cg14736327 chr12:48174669 SLC48A1 -0.72 -5.75 -0.3 2.05e-8 Pneumonia; CRC cis rs6496667 1.000 rs7177486 chr15:90897109 G/A cg04176472 chr15:90893244 GABARAPL3 0.6 8.04 0.41 1.69e-14 Rheumatoid arthritis; CRC cis rs1042058 0.565 rs2480297 chr10:30754512 A/G cg25182066 chr10:30743637 MAP3K8 -0.53 -7.32 -0.37 1.92e-12 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; CRC cis rs875971 0.862 rs801204 chr7:66022921 T/C cg18252515 chr7:66147081 NA 0.43 6.21 0.32 1.62e-9 Aortic root size; CRC cis rs6748734 1.000 rs4311055 chr2:241821017 T/C cg07537917 chr2:241836409 C2orf54 -0.22 -6.3 -0.33 9.55e-10 Urinary metabolites; CRC cis rs1862618 0.853 rs252904 chr5:56118733 A/T cg18230493 chr5:56204884 C5orf35 -0.68 -9.08 -0.45 1.03e-17 Initial pursuit acceleration; CRC cis rs12024301 0.557 rs16828976 chr1:183608481 T/A cg11505048 chr1:183622726 RGL1;APOBEC4 0.81 6.83 0.35 4.19e-11 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs11690935 0.959 rs973889 chr2:172579954 A/G cg13550731 chr2:172543902 DYNC1I2 -1.1 -18.72 -0.72 9.47e-54 Schizophrenia; CRC cis rs7677751 0.806 rs6836215 chr4:55102741 T/C cg00691999 chr4:55094011 PDGFRA 0.4 5.93 0.31 7.46e-9 Corneal astigmatism; CRC cis rs9467773 0.526 rs12199613 chr6:26367218 C/T cg09904177 chr6:26538194 HMGN4 -0.44 -6.04 -0.32 4.12e-9 Intelligence (multi-trait analysis); CRC cis rs10504229 0.593 rs10504216 chr8:57981470 G/A cg02725872 chr8:58115012 NA -0.52 -6.87 -0.35 3.24e-11 Developmental language disorder (linguistic errors); CRC cis rs10256972 0.504 rs2949178 chr7:1209925 T/C cg04025307 chr7:1156635 C7orf50 0.6 9.34 0.46 1.51e-18 Longevity;Endometriosis; CRC cis rs9640161 0.789 rs10952250 chr7:150025966 T/C cg13722127 chr7:150037890 RARRES2 0.48 8.02 0.4 1.82e-14 Blood protein levels;Circulating chemerin levels; CRC cis rs6089584 0.606 rs7270469 chr20:60577258 G/A cg06108461 chr20:60628389 TAF4 -0.63 -10.56 -0.5 1.21e-22 Body mass index; CRC cis rs7274811 0.744 rs209665 chr20:32128889 T/G cg03904042 chr20:32255491 NECAB3;C20orf134 -0.49 -7.17 -0.37 5.03e-12 Height; CRC cis rs13118159 0.714 rs6843025 chr4:1334418 C/G cg20092199 chr4:1342459 KIAA1530 0.45 8.15 0.41 7.71e-15 Longevity; CRC cis rs4423214 0.592 rs79634040 chr11:71230169 G/C cg05163923 chr11:71159392 DHCR7 -0.54 -5.73 -0.3 2.22e-8 Vitamin D levels; CRC cis rs853679 0.517 rs9380047 chr6:28037893 G/T cg12273811 chr6:28175739 NA 0.69 8.81 0.44 7.29e-17 Depression; CRC cis rs13108904 0.935 rs2293633 chr4:1291640 T/C cg20887711 chr4:1340912 KIAA1530 0.48 7.14 0.37 5.91e-12 Obesity-related traits; CRC cis rs4654899 0.929 rs7552999 chr1:21314454 T/C cg02927042 chr1:21476669 EIF4G3 -0.49 -7.92 -0.4 3.64e-14 Superior frontal gyrus grey matter volume; CRC cis rs7705042 0.865 rs11739961 chr5:141508488 A/C cg07392085 chr5:141489673 NDFIP1 0.46 7.47 0.38 7.1e-13 Asthma; CRC cis rs7589342 0.839 rs12995333 chr2:106436366 A/C cg16077055 chr2:106428750 NCK2 -0.42 -6.24 -0.33 1.33e-9 Addiction; CRC cis rs9828933 0.832 rs2292662 chr3:63897215 C/T cg16258503 chr3:63850278 ATXN7;THOC7 -0.63 -7.02 -0.36 1.24e-11 Type 2 diabetes; CRC cis rs72634258 0.786 rs4405150 chr1:8173672 T/C cg00042356 chr1:8021962 PARK7 -0.56 -6.36 -0.33 6.57e-10 Inflammatory bowel disease; CRC cis rs704795 0.836 rs1647281 chr2:27612938 G/C cg12000995 chr2:27665139 KRTCAP3 -0.3 -6.18 -0.32 1.88e-9 Menopause (age at onset); CRC cis rs4689388 0.890 rs4342257 chr4:6290037 G/C cg00701064 chr4:6280414 WFS1 0.75 12.87 0.58 5.43e-31 Type 2 diabetes and other traits;Type 2 diabetes; CRC cis rs4148883 0.689 rs2602861 chr4:100030896 C/T cg13256891 chr4:100009986 ADH5 0.45 6.43 0.33 4.36e-10 Alcohol dependence; CRC cis rs6831352 0.918 rs34805407 chr4:100050786 C/A cg12011299 chr4:100065546 ADH4 -0.49 -9.27 -0.45 2.61e-18 Alcohol dependence; CRC cis rs863345 0.604 rs2054992 chr1:158506015 G/A cg12129480 chr1:158549410 OR10X1 -0.3 -6.25 -0.33 1.25e-9 Pneumococcal bacteremia; CRC cis rs3026101 0.671 rs1544399 chr17:5305887 C/G cg25236894 chr17:5323110 RPAIN;NUP88 0.42 6.9 0.36 2.74e-11 Body mass index; CRC cis rs9322193 0.923 rs10782316 chr6:150073891 A/C cg07701084 chr6:150067640 NUP43 0.59 8.71 0.43 1.48e-16 Lung cancer; CRC cis rs67311347 1.000 rs12634013 chr3:40452388 T/C cg09455208 chr3:40491958 NA 0.49 9.25 0.45 2.86e-18 Renal cell carcinoma; CRC cis rs992157 0.835 rs13005100 chr2:219151767 C/T cg13835894 chr2:219148914 PNKD;TMBIM1 -0.35 -6.71 -0.35 8.58e-11 Colorectal cancer; CRC cis rs11577318 0.853 rs7541333 chr1:26622889 C/T cg00852783 chr1:26633632 UBXN11 0.42 6.13 0.32 2.49e-9 Granulocyte percentage of myeloid white cells; CRC trans rs2303319 0.504 rs56009150 chr2:162598582 T/C cg23247704 chr1:116518985 SLC22A15 -0.73 -6.21 -0.32 1.57e-9 Cognitive function; CRC cis rs1348850 0.914 rs12612857 chr2:178467144 A/G cg02961200 chr2:178257176 LOC100130691;AGPS 0.53 7.39 0.38 1.21e-12 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs6546550 0.901 rs11902198 chr2:70144596 C/A cg02498382 chr2:70120550 SNRNP27 -0.56 -9.52 -0.46 3.78e-19 Prevalent atrial fibrillation; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg23163999 chr3:125803012 SLC41A3 -0.4 -6.03 -0.32 4.37e-9 Myopia (pathological); CRC cis rs2842992 0.789 rs4235925 chr6:160202860 C/T cg11366901 chr6:160182831 ACAT2 0.98 14.51 0.62 3.26e-37 Age-related macular degeneration (geographic atrophy); CRC cis rs10504229 0.683 rs6998040 chr8:58110155 G/T cg24829409 chr8:58192753 C8orf71 0.57 8.19 0.41 5.76e-15 Developmental language disorder (linguistic errors); CRC cis rs7945718 0.650 rs10831889 chr11:12665834 A/T cg25843174 chr11:12811716 TEAD1 0.41 7.67 0.39 1.99e-13 Educational attainment (years of education); CRC cis rs875971 0.862 rs10240949 chr7:65804417 A/G cg18252515 chr7:66147081 NA 0.4 5.79 0.3 1.63e-8 Aortic root size; CRC cis rs11971779 0.680 rs7805824 chr7:139111169 C/G cg23387468 chr7:139079360 LUC7L2 -0.39 -6.83 -0.35 4.19e-11 Diisocyanate-induced asthma; CRC cis rs4819052 0.851 rs1999335 chr21:46670613 A/G cg02159808 chr21:46707872 POFUT2;LOC642852 0.49 6.4 0.33 5.43e-10 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg27362927 chr21:43299497 PRDM15 0.37 6.01 0.31 4.88e-9 Obesity-related traits; CRC cis rs6912958 0.754 rs4707374 chr6:88255438 T/C cg08069147 chr6:88032118 GJB7;C6orf162 -0.56 -8.42 -0.42 1.17e-15 Monocyte percentage of white cells; CRC trans rs7615952 1.000 rs7616044 chr3:125649354 G/C cg00769240 chr8:12517080 NA -0.54 -6.7 -0.35 9.16e-11 Blood pressure (smoking interaction); CRC cis rs7493 0.853 rs17166879 chr7:95053415 A/G cg19678392 chr7:94953810 PON1 -0.6 -7.35 -0.38 1.54e-12 Yu-Zhi constitution type in type 2 diabetes; CRC trans rs7615952 0.546 rs11711150 chr3:125315663 C/T cg21747405 chr11:67723411 NA -0.49 -6.16 -0.32 2.08e-9 Blood pressure (smoking interaction); CRC trans rs7267979 1.000 rs2500405 chr20:25360826 A/G cg17903999 chr18:56338584 MALT1 0.41 6.54 0.34 2.39e-10 Liver enzyme levels (alkaline phosphatase); CRC cis rs4555082 0.874 rs2816613 chr14:105726367 C/T cg06808227 chr14:105710500 BRF1 -0.62 -8.83 -0.44 6.31e-17 Mean platelet volume;Platelet distribution width; CRC cis rs9926296 0.605 rs886951 chr16:89836865 A/G cg27121462 chr16:89883253 FANCA 0.58 9.24 0.45 3.15e-18 Vitiligo; CRC cis rs8072100 0.967 rs4239163 chr17:45755954 C/T cg25173405 chr17:45401733 C17orf57 -0.45 -6.95 -0.36 2e-11 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg22178761 chr5:1008828 NKD2 -0.38 -6.01 -0.31 4.88e-9 Myopia (pathological); CRC cis rs3026101 0.671 rs739768 chr17:5290703 G/A cg25236894 chr17:5323110 RPAIN;NUP88 0.42 6.84 0.35 3.98e-11 Body mass index; CRC trans rs7615952 0.736 rs11921945 chr3:125643719 A/G cg00769240 chr8:12517080 NA -0.56 -6.8 -0.35 4.87e-11 Blood pressure (smoking interaction); CRC cis rs939584 0.932 rs13013021 chr2:632723 C/T cg03610516 chr2:642275 NA 0.42 5.64 0.3 3.58e-8 Body mass index; CRC cis rs6500596 0.570 rs8055628 chr16:4447477 G/A cg08645402 chr16:4508243 NA 0.5 6.38 0.33 5.84e-10 Schizophrenia; CRC cis rs4713118 0.869 rs9295743 chr6:27715102 G/C cg15845792 chr6:28175446 NA 0.66 9.22 0.45 3.56e-18 Parkinson's disease; CRC cis rs9322193 0.923 rs4870267 chr6:149992708 C/G cg07701084 chr6:150067640 NUP43 0.56 8.29 0.42 2.92e-15 Lung cancer; CRC cis rs6952808 0.825 rs12669937 chr7:1939765 C/T cg21782813 chr7:2030301 MAD1L1 0.46 7.9 0.4 4.35e-14 Bipolar disorder and schizophrenia; CRC cis rs853679 0.517 rs9380059 chr6:28132358 A/C cg21251018 chr6:28226885 NKAPL 0.48 6.17 0.32 2.02e-9 Depression; CRC cis rs4290604 0.588 rs62183338 chr2:237969547 C/G cg23555395 chr2:238036564 NA 0.62 6.15 0.32 2.26e-9 Asthma; CRC cis rs7412746 0.611 rs4319334 chr1:150766822 G/A cg15448220 chr1:150897856 SETDB1 0.45 6.46 0.34 3.73e-10 Melanoma; CRC cis rs1843834 0.539 rs6749402 chr2:225443901 T/G cg22455342 chr2:225449267 CUL3 0.68 9.02 0.45 1.55e-17 IgE levels in asthmatics (D.p. specific); CRC trans rs7615952 0.932 rs1976458 chr3:125647512 T/G cg21747405 chr11:67723411 NA -0.44 -6.27 -0.33 1.15e-9 Blood pressure (smoking interaction); CRC cis rs9549367 0.756 rs9603814 chr13:113900782 C/T cg00898013 chr13:113819073 PROZ 0.42 6.39 0.33 5.53e-10 Platelet distribution width; CRC cis rs7107174 1.000 rs2510045 chr11:77920563 G/T cg02023728 chr11:77925099 USP35 0.53 8.05 0.41 1.52e-14 Testicular germ cell tumor; CRC trans rs7615952 0.736 rs11921945 chr3:125643719 A/G cg07211511 chr3:129823064 LOC729375 -1.11 -18.68 -0.72 1.34e-53 Blood pressure (smoking interaction); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg05609751 chr17:4269695 UBE2G1 0.45 6.22 0.32 1.51e-9 Response to antipsychotic treatment; CRC cis rs782590 0.620 rs4322879 chr2:55797033 G/T cg18811423 chr2:55921094 PNPT1 -0.65 -9.73 -0.47 8e-20 Metabolic syndrome; CRC cis rs6503525 0.628 rs62068171 chr17:38103242 G/A cg24910161 chr17:38119198 GSDMA -0.42 -7.45 -0.38 8.14e-13 Asthma; CRC cis rs929354 1.000 rs1182381 chr7:157043473 G/A cg05182265 chr7:156933206 UBE3C 0.73 13.96 0.61 4.04e-35 Body mass index; CRC cis rs1448094 0.512 rs7137596 chr12:86239884 C/G cg02569458 chr12:86230093 RASSF9 0.43 7.34 0.38 1.68e-12 Major depressive disorder; CRC cis rs7208859 0.573 rs8064686 chr17:29134839 C/T cg13385521 chr17:29058706 SUZ12P 0.74 8.44 0.42 9.97e-16 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC trans rs7726839 0.540 rs11750321 chr5:599196 C/T cg25482853 chr8:67687455 SGK3 1.1 12.97 0.58 2.42e-31 Obesity-related traits; CRC cis rs6912958 0.781 rs9444504 chr6:88181046 A/C cg12350822 chr6:88032061 C6orf162;GJB7 -0.34 -6.24 -0.33 1.34e-9 Monocyte percentage of white cells; CRC cis rs6840360 0.642 rs2724574 chr4:152381800 A/T cg09659197 chr4:152720779 NA -0.32 -6.35 -0.33 6.97e-10 Intelligence (multi-trait analysis); CRC cis rs1799949 0.965 rs9911630 chr17:41188342 A/G cg25072359 chr17:41440525 NA 0.52 8.32 0.42 2.32e-15 Menopause (age at onset); CRC cis rs10504229 0.953 rs67886764 chr8:58187117 T/C cg22535103 chr8:58192502 C8orf71 -0.82 -12.27 -0.56 9.63e-29 Developmental language disorder (linguistic errors); CRC cis rs1348850 0.914 rs7565022 chr2:178320222 A/T cg22681709 chr2:178499509 PDE11A -0.36 -6.68 -0.35 1.03e-10 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs10751667 0.600 rs10902266 chr11:1005697 G/T cg23136738 chr11:925521 AP2A2 -0.4 -6.07 -0.32 3.43e-9 Alzheimer's disease (late onset); CRC cis rs2692947 0.655 rs2315668 chr2:96429562 T/C cg23100626 chr2:96804247 ASTL 0.26 6.61 0.34 1.51e-10 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; CRC trans rs3931020 0.720 rs927904 chr1:75260328 A/G cg10612998 chr14:21572012 ZNF219 0.46 5.97 0.31 6.27e-9 Resistin levels; CRC cis rs863345 0.604 rs1342950 chr1:158463723 G/A cg12129480 chr1:158549410 OR10X1 -0.3 -6.32 -0.33 8.42e-10 Pneumococcal bacteremia; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg23260799 chr11:451101 PTDSS2 0.5 6.68 0.35 1.02e-10 Thyroid stimulating hormone; CRC cis rs9487051 0.714 rs9487058 chr6:109631060 A/C cg01475377 chr6:109611718 NA -0.38 -6.73 -0.35 7.55e-11 Reticulocyte fraction of red cells; CRC cis rs8077889 0.917 rs60335331 chr17:41907509 A/G cg25876840 chr17:41920477 NA 0.51 7.64 0.39 2.39e-13 Triglycerides; CRC cis rs5750830 0.621 rs5750810 chr22:39792943 A/G cg11247378 chr22:39784982 NA -0.45 -8.53 -0.43 5.6e-16 Intelligence (multi-trait analysis); CRC cis rs748404 0.697 rs475261 chr15:43546456 C/T cg02155558 chr15:43621948 ADAL;LCMT2 0.4 5.98 0.31 5.9e-9 Lung cancer; CRC cis rs7618915 0.508 rs7628578 chr3:52628321 A/T cg10802521 chr3:52805072 NEK4 -0.58 -9.14 -0.45 6.65e-18 Bipolar disorder; CRC cis rs4713118 0.669 rs200997 chr6:27811815 G/A cg15845792 chr6:28175446 NA 0.66 9.3 0.46 2.02e-18 Parkinson's disease; CRC cis rs929354 0.742 rs7801905 chr7:156940111 T/C cg17757837 chr7:157058334 UBE3C 0.74 12.39 0.56 3.31e-29 Body mass index; CRC cis rs950169 0.580 rs11630887 chr15:85193015 A/T cg17507749 chr15:85114479 UBE2QP1 0.63 8.94 0.44 2.77e-17 Schizophrenia; CRC cis rs13191362 1.000 rs36042757 chr6:163004744 A/C cg06582575 chr6:163149167 PACRG;PARK2 0.73 10.55 0.5 1.3e-22 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC trans rs1814175 0.619 rs10769623 chr11:49865926 C/T cg15704280 chr7:45808275 SEPT13 -0.93 -16.5 -0.67 5.24e-45 Height; CRC cis rs6938 0.514 rs56338926 chr15:75259335 C/A cg09165964 chr15:75287851 SCAMP5 0.52 7.66 0.39 2.15e-13 Breast cancer; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg17942371 chr19:796826 PTBP1 0.48 7.08 0.36 8.66e-12 Response to antipsychotic treatment; CRC cis rs1728785 1.000 rs7196104 chr16:68579746 C/A cg02972257 chr16:68554789 NA -0.58 -7.24 -0.37 3.21e-12 Ulcerative colitis; CRC cis rs7224685 0.501 rs2676276 chr17:3919981 C/T cg09695851 chr17:3907499 NA -0.73 -14.26 -0.62 2.91e-36 Type 2 diabetes; CRC cis rs9467711 0.651 rs16891334 chr6:26124303 T/C cg19084075 chr6:26124329 HIST1H2AC;HIST1H2BC 0.66 6.03 0.32 4.49e-9 Autism spectrum disorder or schizophrenia; CRC cis rs6940638 0.688 rs2022272 chr6:27103580 A/G cg12292205 chr6:26970375 C6orf41 -0.52 -7.6 -0.39 3.12e-13 Intelligence (multi-trait analysis); CRC trans rs1005277 0.541 rs2505193 chr10:38394638 G/C cg17830980 chr10:43048298 ZNF37B -0.6 -9.98 -0.48 1.19e-20 Extrinsic epigenetic age acceleration; CRC trans rs1997103 0.911 rs9642575 chr7:55399090 C/T cg20935933 chr6:143382018 AIG1 0.53 6.82 0.35 4.42e-11 QRS interval (sulfonylurea treatment interaction); CRC trans rs2243480 1.000 rs316304 chr7:65616894 T/C cg10756647 chr7:56101905 PSPH 0.76 7.89 0.4 4.47e-14 Diabetic kidney disease; CRC cis rs9660992 0.573 rs12140422 chr1:205187981 G/A cg21643547 chr1:205240462 TMCC2 -0.37 -6.01 -0.31 4.94e-9 Mean corpuscular volume;Mean platelet volume; CRC cis rs7727544 1.000 rs7727038 chr5:131590257 C/T cg09877947 chr5:131593287 PDLIM4 0.38 7.21 0.37 3.96e-12 Blood metabolite levels; CRC cis rs10849893 0.554 rs10849888 chr12:121892786 A/G cg01154721 chr12:121881891 KDM2B -0.43 -6.23 -0.32 1.43e-9 Fasting blood glucose;Fasting blood glucose (BMI interaction); CRC cis rs1552244 0.882 rs55840655 chr3:10042690 C/T cg18598329 chr3:10140678 FANCD2;C3orf24 -0.81 -10.69 -0.51 4.35e-23 Alzheimer's disease; CRC cis rs67311347 0.955 rs60554147 chr3:40472503 T/C cg09455208 chr3:40491958 NA 0.43 8.72 0.43 1.36e-16 Renal cell carcinoma; CRC cis rs9296095 0.632 rs6914422 chr6:33534880 A/G cg14003231 chr6:33640908 ITPR3 -0.46 -7.11 -0.36 7.49e-12 Platelet count; CRC cis rs6121246 0.609 rs1009453 chr20:30404840 C/G cg13852791 chr20:30311386 BCL2L1 0.76 15.0 0.64 4.08e-39 Mean corpuscular hemoglobin; CRC trans rs333332 0.961 rs333333 chr3:124328388 G/A cg08451243 chr11:1273788 MUC5B 0.41 6.49 0.34 3.17e-10 Heschl's gyrus morphology; CRC cis rs9311474 0.507 rs6787154 chr3:52784416 C/T cg18099408 chr3:52552593 STAB1 -0.47 -7.83 -0.4 6.78e-14 Electroencephalogram traits; CRC cis rs7412746 0.658 rs8444 chr1:150938571 G/A cg15448220 chr1:150897856 SETDB1 0.57 8.3 0.42 2.66e-15 Melanoma; CRC cis rs9486715 0.867 rs9373887 chr6:96957004 C/T cg06623918 chr6:96969491 KIAA0776 1.03 20.48 0.75 1.08e-60 Headache; CRC cis rs7258465 1.000 rs10411009 chr19:18606266 A/G cg06953865 chr19:18549723 ISYNA1 -0.39 -6.01 -0.31 4.89e-9 Breast cancer; CRC trans rs3749237 1.000 rs2291542 chr3:49751585 C/T cg21659725 chr3:3221576 CRBN 0.56 8.11 0.41 9.82e-15 Resting heart rate; CRC cis rs3617 0.625 rs7652667 chr3:52866535 C/A cg15147215 chr3:52552868 STAB1 0.53 9.22 0.45 3.79e-18 Red blood cell count;Autism spectrum disorder or schizophrenia; CRC cis rs17685 0.753 rs1104879 chr7:75685568 C/T cg16489192 chr7:75678113 MDH2;STYXL1 -0.35 -5.6 -0.3 4.42e-8 Coffee consumption;Coffee consumption (cups per day); CRC cis rs10504229 0.683 rs7459958 chr8:58111905 G/T cg21724239 chr8:58056113 NA 0.5 6.89 0.35 2.89e-11 Developmental language disorder (linguistic errors); CRC cis rs1005277 0.579 rs1780138 chr10:38501654 A/G cg00409905 chr10:38381863 ZNF37A -0.62 -10.29 -0.49 1.03e-21 Extrinsic epigenetic age acceleration; CRC cis rs7666738 0.962 rs4699596 chr4:99012924 C/T cg17366294 chr4:99064904 C4orf37 0.45 7.31 0.37 1.98e-12 Colonoscopy-negative controls vs population controls; CRC cis rs4481887 0.893 rs1934543 chr1:248505602 C/G cg00666640 chr1:248458726 OR2T12 0.5 9.28 0.46 2.3e-18 Common traits (Other); CRC cis rs4713118 0.662 rs464312 chr6:27967591 T/A cg02683197 chr6:28174875 NA 0.65 9.03 0.45 1.48e-17 Parkinson's disease; CRC cis rs10876993 0.806 rs1689598 chr12:58050500 G/C cg18357645 chr12:58087776 OS9 0.58 7.87 0.4 5.23e-14 Celiac disease or Rheumatoid arthritis; CRC cis rs9486719 0.843 rs2472875 chr6:96844691 G/A cg06623918 chr6:96969491 KIAA0776 0.79 8.57 0.43 4.23e-16 Migraine;Coronary artery disease; CRC cis rs17767392 0.881 rs757850 chr14:72016006 C/G cg13720639 chr14:72061746 SIPA1L1 0.54 7.01 0.36 1.32e-11 Mitral valve prolapse; CRC cis rs950169 1.000 rs12902672 chr15:84716986 G/A cg11189052 chr15:85197271 WDR73 0.61 8.89 0.44 4.18e-17 Schizophrenia; CRC trans rs1325598 0.935 rs1325596 chr1:176794066 G/A cg03992096 chr13:114928177 NA -0.38 -6.04 -0.32 4.1e-9 Height; CRC cis rs7246657 0.943 rs13345116 chr19:37847098 A/T cg23950597 chr19:37808831 NA -0.47 -5.76 -0.3 1.94e-8 Coronary artery calcification; CRC trans rs951252 0.504 rs11734405 chr4:146081096 C/T cg11866396 chr17:5322940 RPAIN;NUP88 0.46 6.36 0.33 6.74e-10 Hip circumference; CRC cis rs1215050 0.740 rs783924 chr4:98969234 C/T cg05340658 chr4:99064831 C4orf37 -0.49 -7.52 -0.38 5.41e-13 Waist-to-hip ratio adjusted for body mass index; CRC cis rs9611565 0.512 rs139571 chr22:42214238 G/A cg06481639 chr22:41940642 POLR3H -0.63 -6.98 -0.36 1.63e-11 Vitiligo; CRC cis rs6456156 0.811 rs975822 chr6:167516458 C/T cg07513332 chr6:167530253 CCR6 -0.39 -7.01 -0.36 1.4e-11 Primary biliary cholangitis; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg12661088 chr5:43120934 ZNF131 0.46 5.98 0.31 5.82e-9 Thyroid stimulating hormone; CRC cis rs3892630 0.588 rs7245709 chr19:33242755 C/T cg22980127 chr19:33182716 NUDT19 0.92 12.32 0.56 6.34e-29 Red blood cell traits; CRC cis rs28386778 0.897 rs4968599 chr17:61835992 T/C cg06873352 chr17:61820015 STRADA 0.79 14.96 0.64 5.82e-39 Prudent dietary pattern; CRC cis rs9304742 1.000 rs9304742 chr19:53451291 A/G cg09915433 chr19:53449742 NA -0.66 -10.25 -0.49 1.42e-21 Psoriasis; CRC trans rs1005277 0.579 rs1780133 chr10:38499509 T/C cg23533926 chr12:111358616 MYL2 -0.56 -8.7 -0.43 1.64e-16 Extrinsic epigenetic age acceleration; CRC cis rs8060686 0.920 rs73591968 chr16:67803063 G/A cg08314208 chr16:67682810 RLTPR -0.65 -7.04 -0.36 1.12e-11 HDL cholesterol;Metabolic syndrome; CRC cis rs9467711 0.651 rs13191776 chr6:25955741 C/T cg08501292 chr6:25962987 TRIM38 1.06 9.09 0.45 9.76e-18 Autism spectrum disorder or schizophrenia; CRC cis rs1046896 0.594 rs8070403 chr17:80865404 A/G cg19500275 chr17:80737654 TBCD 0.54 7.48 0.38 6.82e-13 Glycated hemoglobin levels; CRC cis rs11098499 0.645 rs72676059 chr4:120290828 C/G cg09307838 chr4:120376055 NA 0.68 10.53 0.5 1.51e-22 Corneal astigmatism; CRC cis rs1904096 0.506 rs3113863 chr4:95147827 G/C cg11021082 chr4:95130006 SMARCAD1 -0.61 -9.61 -0.47 1.9e-19 Type 2 diabetes; CRC cis rs7208859 0.623 rs75136574 chr17:28934549 C/A cg19761014 chr17:28927070 LRRC37B2 0.59 5.88 0.31 1.02e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs2979489 1.000 rs2979469 chr8:30285091 C/G cg26383811 chr8:30366931 RBPMS 0.61 8.54 0.43 5.05e-16 Mean corpuscular hemoglobin;Plateletcrit;Neutrophil count;Granulocyte count;Sum basophil neutrophil counts;Mean corpuscular volume;Myeloid white cell count;Sum neutrophil eosinophil counts; CRC cis rs6933660 0.760 rs3806982 chr6:151774916 G/A cg14262678 chr6:151773367 RMND1;C6orf211 0.55 9.08 0.45 1.04e-17 Menarche (age at onset); CRC cis rs9457247 0.602 rs9459854 chr6:167465882 C/T cg07741184 chr6:167504864 NA 0.44 7.42 0.38 1.02e-12 Crohn's disease; CRC cis rs9322193 0.884 rs880245 chr6:150167398 A/G cg05861140 chr6:150128134 PCMT1 0.41 6.39 0.33 5.72e-10 Lung cancer; CRC cis rs35146811 1.000 rs35146811 chr7:99720994 A/C cg13334819 chr7:99746414 C7orf59 -0.62 -8.12 -0.41 9.71e-15 Coronary artery disease; CRC cis rs950169 0.845 rs4502182 chr15:84923520 A/G cg11189052 chr15:85197271 WDR73 0.64 8.98 0.44 2.15e-17 Schizophrenia; CRC trans rs1823549 0.793 rs10735772 chr1:103153132 C/A cg08492707 chr21:34696952 IFNAR1 -0.75 -6.0 -0.31 5.24e-9 Systemic juvenile idiopathic arthritis; CRC cis rs270601 0.661 rs10036208 chr5:131571323 T/C cg02033258 chr5:131593261 PDLIM4 0.5 8.84 0.44 6.01e-17 Acylcarnitine levels; CRC cis rs6740322 0.895 rs6711966 chr2:43561989 C/T cg06169590 chr2:43455088 ZFP36L2;LOC100129726 -0.57 -7.23 -0.37 3.48e-12 Coronary artery disease; CRC trans rs12599106 0.624 rs2173885 chr16:34992749 G/A cg07332563 chr6:291687 DUSP22 -0.6 -8.67 -0.43 2.02e-16 Menopause (age at onset); CRC cis rs7945705 0.818 rs4929916 chr11:8824996 C/T cg14711859 chr11:8959438 ASCL3 -0.35 -5.91 -0.31 8.64e-9 Hemoglobin concentration; CRC cis rs589448 0.538 rs683790 chr12:69751434 T/G cg14784868 chr12:69753453 YEATS4 0.66 8.92 0.44 3.39e-17 Cerebrospinal fluid biomarker levels; CRC cis rs7618915 0.547 rs62253703 chr3:52632357 T/C cg10802521 chr3:52805072 NEK4 -0.59 -9.08 -0.45 1.05e-17 Bipolar disorder; CRC cis rs2153535 0.580 rs2143356 chr6:8517675 C/T cg21535247 chr6:8435926 SLC35B3 0.48 7.35 0.38 1.63e-12 Motion sickness; CRC cis rs9611565 0.592 rs12484467 chr22:41957610 T/C cg03806693 chr22:41940476 POLR3H -1.01 -12.11 -0.56 3.64e-28 Vitiligo; CRC cis rs9354308 0.899 rs2802057 chr6:66548093 A/C cg07460842 chr6:66804631 NA 0.46 5.68 0.3 2.95e-8 Metabolite levels; CRC cis rs7527798 0.571 rs4844611 chr1:207827538 G/C cg21110645 chr1:207815933 NA -0.39 -6.18 -0.32 1.9e-9 Erythrocyte sedimentation rate; CRC cis rs17711722 0.640 rs13237956 chr7:65318029 G/A cg05627663 chr7:65219948 SNORA22;CCT6P1 0.49 7.37 0.38 1.41e-12 Calcium levels; CRC cis rs9467711 0.651 rs35778245 chr6:25944803 G/A cg16898833 chr6:26189333 HIST1H4D 0.64 5.73 0.3 2.27e-8 Autism spectrum disorder or schizophrenia; CRC cis rs10197940 0.624 rs6724796 chr2:152412813 C/T cg19508488 chr2:152266495 RIF1 0.58 8.75 0.43 1.15e-16 Lung cancer; CRC cis rs2013441 0.866 rs17686622 chr17:20020364 C/G cg13482628 chr17:19912719 NA -0.39 -5.72 -0.3 2.4e-8 Obesity-related traits; CRC cis rs1129187 1.000 rs1129187 chr6:42932200 G/T cg05552183 chr6:42928497 GNMT 0.62 9.79 0.48 4.85e-20 Alzheimer's disease in APOE e4+ carriers; CRC cis rs344364 0.511 rs1742469 chr16:1950244 C/T cg00046913 chr16:1877150 HAGH;FAHD1 -0.58 -6.06 -0.32 3.66e-9 Glomerular filtration rate in chronic kidney disease; CRC cis rs7408868 0.764 rs45504393 chr19:15277010 A/G cg14696996 chr19:15285081 NOTCH3 0.96 9.0 0.44 1.82e-17 Pulse pressure; CRC trans rs61931739 0.500 rs6488211 chr12:34375620 A/T cg26384229 chr12:38710491 ALG10B -0.65 -8.91 -0.44 3.43e-17 Morning vs. evening chronotype; CRC cis rs8062405 1.000 rs62037364 chr16:28868695 G/A cg08761264 chr16:28874980 SH2B1 -0.44 -5.84 -0.31 1.27e-8 Cognitive ability (multi-trait analysis);Cognitive ability; CRC cis rs9733 0.596 rs12072339 chr1:150686099 A/G cg15448220 chr1:150897856 SETDB1 0.45 6.41 0.33 5.09e-10 Tonsillectomy; CRC trans rs6703335 0.870 rs10803142 chr1:243598234 A/G cg20989729 chr11:101981056 YAP1 0.45 6.62 0.34 1.43e-10 Schizophrenia;Schizophrenia, schizoaffective disorder or bipolar disorder; CRC cis rs782590 0.967 rs2627759 chr2:55853341 T/C cg18811423 chr2:55921094 PNPT1 0.8 14.71 0.63 5.58e-38 Metabolic syndrome; CRC cis rs208520 0.690 rs12202805 chr6:66703903 A/G cg07460842 chr6:66804631 NA -1.0 -13.84 -0.61 1.19e-34 Exhaled nitric oxide output; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg05793409 chr1:35658810 SFPQ 0.42 6.07 0.32 3.56e-9 Intelligence (multi-trait analysis); CRC cis rs736408 0.609 rs2230535 chr3:52800284 T/C cg10802521 chr3:52805072 NEK4 -0.59 -9.03 -0.45 1.48e-17 Bipolar disorder; CRC cis rs7178572 0.568 rs4243045 chr15:77455914 A/C cg22256960 chr15:77711686 NA -0.66 -9.41 -0.46 8.66e-19 Type 2 diabetes; CRC cis rs62408225 1.000 rs55771973 chr6:90981319 T/G cg06866423 chr6:90926672 BACH2 0.5 8.15 0.41 7.56e-15 Eosinophil counts;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC trans rs66573146 0.634 rs55633489 chr4:6988745 C/A cg07817883 chr1:32538562 TMEM39B 1.32 12.42 0.56 2.68e-29 Granulocyte percentage of myeloid white cells; CRC cis rs62244186 0.748 rs2888410 chr3:44655476 A/C cg10263370 chr3:44754102 ZNF502 -0.38 -6.39 -0.33 5.64e-10 Depressive symptoms; CRC cis rs6502050 0.871 rs9916649 chr17:80075739 G/A cg11859384 chr17:80120422 CCDC57 0.37 5.82 0.31 1.43e-8 Life satisfaction; CRC cis rs881375 0.900 rs2241003 chr9:123666777 G/C cg14255062 chr9:123606675 PSMD5;LOC253039 0.42 6.46 0.34 3.81e-10 Rheumatoid arthritis; CRC cis rs4148883 0.675 rs34511427 chr4:100105405 G/T cg13256891 chr4:100009986 ADH5 0.43 6.23 0.32 1.43e-9 Alcohol dependence; CRC cis rs7312933 1.000 rs12372597 chr12:42412850 C/T cg01256987 chr12:42539512 GXYLT1 -0.43 -6.47 -0.34 3.47e-10 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CRC cis rs2836950 0.565 rs3171465 chr21:40552307 A/G cg06238570 chr21:40685208 BRWD1 -0.62 -9.04 -0.45 1.36e-17 Menarche (age at onset); CRC cis rs208520 0.690 rs866452 chr6:66849936 A/T cg07460842 chr6:66804631 NA -1.04 -14.51 -0.62 3.1e-37 Exhaled nitric oxide output; CRC cis rs8031584 0.958 rs61997079 chr15:31238271 G/C cg08704250 chr15:31115839 NA -0.44 -7.96 -0.4 2.86e-14 Huntington's disease progression; CRC cis rs3087591 0.922 rs11867284 chr17:29597464 G/A cg24425628 chr17:29625626 OMG;NF1 0.84 16.5 0.67 5.37e-45 Hip circumference; CRC cis rs7493 1.000 rs2040993 chr7:95047300 T/A cg17330251 chr7:94953956 PON1 -0.56 -7.25 -0.37 3.02e-12 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs9915657 0.870 rs12600458 chr17:70130545 C/T cg09344028 chr17:70110421 NA 0.43 6.5 0.34 2.96e-10 Thyroid hormone levels; CRC cis rs910316 0.967 rs175498 chr14:75536369 G/A cg08847533 chr14:75593920 NEK9 -0.91 -16.9 -0.68 1.44e-46 Height; CRC cis rs9796 0.621 rs2578655 chr15:41462809 T/G cg18705301 chr15:41695430 NDUFAF1 -0.43 -7.02 -0.36 1.25e-11 Menopause (age at onset); CRC cis rs10782582 0.593 rs11163915 chr1:76130199 C/T cg10523679 chr1:76189770 ACADM -0.4 -5.66 -0.3 3.28e-8 Daytime sleep phenotypes; CRC cis rs72781680 0.752 rs72796119 chr2:23917179 C/T cg08917208 chr2:24149416 ATAD2B 0.99 9.16 0.45 5.85e-18 Lymphocyte counts; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg21146272 chr6:42858716 C6orf226 0.51 7.19 0.37 4.33e-12 Response to antipsychotic treatment; CRC cis rs12042938 1.000 rs11122319 chr1:231808282 C/T cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.47 -6.4 -0.33 5.5e-10 Neuranatomic and neurocognitive phenotypes; CRC cis rs8063761 0.589 rs4238833 chr16:90050689 G/T cg12064134 chr16:90016061 DEF8 0.57 9.46 0.46 5.93e-19 Squamous cell carcinoma; CRC cis rs72720396 0.694 rs6689362 chr1:91203251 T/A cg13456504 chr1:91191583 NA -0.38 -5.96 -0.31 6.34e-9 Morning vs. evening chronotype;Chronotype; CRC cis rs2033711 0.870 rs4801583 chr19:58918405 A/G cg00825309 chr19:58991885 ZNF446 -0.46 -6.64 -0.34 1.28e-10 Uric acid clearance; CRC cis rs1448094 0.511 rs17279133 chr12:86162353 G/A cg25456477 chr12:86230367 RASSF9 0.38 6.43 0.33 4.41e-10 Major depressive disorder; CRC cis rs3617 0.599 rs12487379 chr3:52895785 G/A cg05573699 chr3:52720067 GNL3;PBRM1 -0.4 -5.81 -0.3 1.51e-8 Red blood cell count;Autism spectrum disorder or schizophrenia; CRC trans rs6600671 1.000 rs1591882 chr1:121183313 G/A cg00646200 chr1:148855367 NA 0.36 6.62 0.34 1.5e-10 Hip geometry; CRC cis rs10504229 0.683 rs2318147 chr8:58114931 C/T cg02290350 chr8:58132656 NA -0.57 -6.8 -0.35 5.02e-11 Developmental language disorder (linguistic errors); CRC cis rs6815814 0.898 rs5743592 chr4:38803063 A/G cg06935464 chr4:38784597 TLR10 0.58 6.14 0.32 2.44e-9 Breast cancer; CRC cis rs208520 1.000 rs12190773 chr6:66968194 T/C cg07460842 chr6:66804631 NA 0.92 11.45 0.53 8.97e-26 Exhaled nitric oxide output; CRC cis rs798554 0.644 rs1639040 chr7:2884116 G/T cg19717773 chr7:2847554 GNA12 -0.43 -6.11 -0.32 2.82e-9 Height; CRC cis rs6502050 0.835 rs67106357 chr17:80116826 T/G cg02741985 chr17:80059408 CCDC57 0.43 7.18 0.37 4.56e-12 Life satisfaction; CRC cis rs780096 0.526 rs780106 chr2:27681598 A/C cg17158414 chr2:27665306 KRTCAP3 -0.3 -6.68 -0.35 9.98e-11 Total body bone mineral density; CRC cis rs6089584 0.819 rs1467593 chr20:60601432 T/G cg23262073 chr20:60523788 NA 0.48 7.17 0.37 4.86e-12 Body mass index; CRC cis rs801193 1.000 rs3800812 chr7:66223461 T/C cg11764359 chr7:65958608 NA 0.54 8.31 0.42 2.48e-15 Aortic root size; CRC cis rs4718428 0.705 rs13231140 chr7:66361618 C/G cg18252515 chr7:66147081 NA -0.55 -7.65 -0.39 2.3e-13 Corneal structure; CRC cis rs4862750 1.000 rs4862751 chr4:187904050 G/A cg27532560 chr4:187881888 NA -0.57 -10.07 -0.49 5.72e-21 Lobe attachment (rater-scored or self-reported); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg07050827 chr2:228280252 NA 0.44 6.89 0.36 2.83e-11 Liver disease severity in Alagille syndrome; CRC cis rs2243480 1.000 rs313798 chr7:65493031 A/G cg25985355 chr7:65971099 NA -0.51 -5.83 -0.31 1.3e-8 Diabetic kidney disease; CRC cis rs6762 0.748 rs1130719 chr11:838760 T/A cg16425592 chr11:842748 TSPAN4;POLR2L -0.56 -8.25 -0.41 3.81e-15 Mean platelet volume; CRC cis rs6693567 0.545 rs7411534 chr1:150447269 C/T cg04165759 chr1:150448943 RPRD2 0.36 5.87 0.31 1.04e-8 Migraine; CRC cis rs992157 0.835 rs13031757 chr2:219151926 T/C cg04880052 chr2:219191631 PNKD -0.43 -6.8 -0.35 4.82e-11 Colorectal cancer; CRC cis rs9733 0.596 rs3087960 chr1:150620569 C/G cg18016565 chr1:150552671 MCL1 0.47 6.78 0.35 5.7e-11 Tonsillectomy; CRC cis rs6582630 0.548 rs1607870 chr12:38385964 G/T cg26384229 chr12:38710491 ALG10B -0.53 -7.78 -0.39 9.24e-14 Drug-induced liver injury (flucloxacillin); CRC cis rs9733 0.536 rs10888385 chr1:150574302 T/C cg18016565 chr1:150552671 MCL1 -0.47 -7.16 -0.37 5.15e-12 Tonsillectomy; CRC cis rs11764590 0.585 rs11772463 chr7:2078132 A/C cg24505167 chr7:1915268 MAD1L1 -0.42 -5.71 -0.3 2.5e-8 Neuroticism; CRC trans rs2908835 0.521 rs10772472 chr12:11610348 G/A cg03979024 chr10:419189 DIP2C -0.39 -6.1 -0.32 3.05e-9 Information processing speed; CRC cis rs9322193 0.886 rs4870055 chr6:150169569 C/T cg13206674 chr6:150067644 NUP43 0.55 8.01 0.4 1.95e-14 Lung cancer; CRC cis rs1215050 0.791 rs7681599 chr4:98664109 C/T cg05340658 chr4:99064831 C4orf37 -0.47 -7.01 -0.36 1.4e-11 Waist-to-hip ratio adjusted for body mass index; CRC cis rs12369635 1.000 rs73159540 chr12:129559421 C/T cg01909103 chr12:129572610 TMEM132D -0.74 -6.4 -0.33 5.45e-10 Schizophrenia (inflammation and infection response interaction); CRC cis rs9826463 0.702 rs56397702 chr3:142304764 C/T cg20824294 chr3:142316082 PLS1 0.42 6.69 0.35 9.5e-11 QRS duration in Tripanosoma cruzi seropositivity; CRC cis rs12580194 0.593 rs55659159 chr12:55747754 C/T cg23425280 chr12:56401806 NA 0.44 5.61 0.3 4.19e-8 Cancer; CRC cis rs3820928 1.000 rs10204368 chr2:227774244 G/C cg11843606 chr2:227700838 RHBDD1 -0.41 -5.96 -0.31 6.39e-9 Pulmonary function; CRC cis rs8180040 0.800 rs6768221 chr3:47296899 C/G cg10298567 chr3:47292165 KIF9 0.42 6.56 0.34 2.07e-10 Colorectal cancer; CRC cis rs2239547 0.618 rs4687663 chr3:52870618 T/A cg10802521 chr3:52805072 NEK4 -0.45 -6.1 -0.32 3.05e-9 Schizophrenia; CRC cis rs524281 0.861 rs11227410 chr11:65873396 G/C cg16950941 chr11:66035639 RAB1B -0.6 -7.43 -0.38 9.41e-13 Electroencephalogram traits; CRC cis rs2836950 0.501 rs35994303 chr21:40686020 C/T cg17971929 chr21:40555470 PSMG1 -0.53 -7.46 -0.38 7.58e-13 Menarche (age at onset); CRC cis rs2645694 0.626 rs2703119 chr4:77823640 C/T cg18351406 chr4:77819688 ANKRD56 0.51 7.87 0.4 5.17e-14 Emphysema distribution in smoking; CRC cis rs172166 0.694 rs536704 chr6:28092603 T/G cg02683197 chr6:28174875 NA 0.65 9.1 0.45 9.16e-18 Cardiac Troponin-T levels; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg05985164 chr12:57881757 MARS 0.39 6.1 0.32 3.01e-9 Liver disease severity in Alagille syndrome; CRC cis rs6540559 0.673 rs926346 chr1:209962204 A/T cg21951975 chr1:209979733 IRF6 0.49 6.61 0.34 1.54e-10 Cleft lip with or without cleft palate; CRC cis rs847577 0.630 rs11764933 chr7:97825188 G/A cg24562669 chr7:97807699 LMTK2 0.79 17.64 0.7 1.72e-49 Breast cancer; CRC cis rs9910055 0.718 rs7212854 chr17:42254417 A/G cg13607699 chr17:42295918 UBTF 0.47 6.28 0.33 1.09e-9 Total body bone mineral density; CRC cis rs16936870 0.543 rs2957094 chr8:71070527 A/T cg14232793 chr8:71155543 NCOA2 -0.46 -5.77 -0.3 1.81e-8 QT interval; CRC trans rs9561329 0.800 rs4773743 chr13:94036176 C/G cg23072629 chr2:239195537 PER2 0.33 6.25 0.33 1.24e-9 Neuroticism (age interaction); CRC cis rs7072216 0.727 rs942808 chr10:100168102 C/A cg26618903 chr10:100175079 PYROXD2 -0.55 -9.26 -0.45 2.73e-18 Metabolite levels; CRC cis rs9649213 0.593 rs7795176 chr7:97978287 A/C cg21770322 chr7:97807741 LMTK2 0.53 8.73 0.43 1.33e-16 Prostate cancer (SNP x SNP interaction); CRC trans rs2303319 0.504 rs62189043 chr2:162608466 A/T cg22677401 chr17:46026860 NA -0.67 -6.07 -0.32 3.57e-9 Cognitive function; CRC cis rs12477438 0.520 rs13798 chr2:99813614 T/C cg26064155 chr2:99771622 LIPT1;TSGA10 0.81 14.27 0.62 2.75e-36 Chronic sinus infection; CRC cis rs8031584 0.697 rs8036176 chr15:31175269 A/G cg08109568 chr15:31115862 NA -0.62 -9.38 -0.46 1.14e-18 Huntington's disease progression; CRC cis rs1728785 1.000 rs1170445 chr16:68573064 G/T cg02972257 chr16:68554789 NA -0.58 -7.15 -0.37 5.78e-12 Ulcerative colitis; CRC cis rs6951245 0.744 rs1133122 chr7:1192572 C/A cg20603222 chr7:1096387 C7orf50;GPR146 -0.63 -7.78 -0.39 9.25e-14 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs10504229 1.000 rs17216711 chr8:58170856 T/C cg05313129 chr8:58192883 C8orf71 -0.47 -6.99 -0.36 1.49e-11 Developmental language disorder (linguistic errors); CRC cis rs2019137 0.539 rs6755040 chr2:113981137 T/C cg21482265 chr2:113992762 PAX8;LOC440839;LOC654433 0.62 9.45 0.46 6.81e-19 Lymphocyte counts; CRC cis rs7259376 0.875 rs1091182 chr19:22475622 G/A cg02657401 chr19:22469223 NA 0.38 8.43 0.42 1.08e-15 Menopause (age at onset); CRC cis rs9322817 0.691 rs6571207 chr6:105242161 A/C cg02098413 chr6:105308735 HACE1 -0.44 -8.52 -0.43 5.86e-16 Thyroid stimulating hormone; CRC cis rs921968 0.565 rs6436084 chr2:219639782 A/G cg02176678 chr2:219576539 TTLL4 -0.41 -6.52 -0.34 2.65e-10 Mean corpuscular hemoglobin concentration; CRC cis rs7618501 0.633 rs6771546 chr3:49968572 T/C cg05623727 chr3:50126028 RBM5 0.45 7.59 0.39 3.28e-13 Intelligence (multi-trait analysis); CRC cis rs6951245 1.000 rs74652290 chr7:1090109 G/A cg04025307 chr7:1156635 C7orf50 0.63 6.77 0.35 5.84e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs11122272 0.735 rs11122280 chr1:231519816 T/C cg06096015 chr1:231504339 EGLN1 0.37 5.62 0.3 4.04e-8 Hemoglobin concentration; CRC cis rs1552244 0.938 rs7625049 chr3:10115619 C/T cg00166722 chr3:10149974 C3orf24 0.67 9.23 0.45 3.37e-18 Alzheimer's disease; CRC cis rs72730918 0.540 rs2252220 chr15:51934783 G/A cg14296394 chr15:51910925 DMXL2 -0.47 -6.32 -0.33 8.69e-10 Intelligence (multi-trait analysis); CRC cis rs7829975 0.714 rs59046059 chr8:8670736 C/A cg08975724 chr8:8085496 FLJ10661 0.47 7.06 0.36 9.71e-12 Mood instability; CRC cis rs1552244 1.000 rs7622966 chr3:10139833 C/T cg18598329 chr3:10140678 FANCD2;C3orf24 -0.9 -13.24 -0.59 2.25e-32 Alzheimer's disease; CRC cis rs4713118 0.539 rs200967 chr6:27862127 A/G cg12172441 chr6:28176163 NA 0.5 6.67 0.35 1.09e-10 Parkinson's disease; CRC cis rs10927875 0.518 rs732286 chr1:16344360 A/G cg22431228 chr1:16359049 CLCNKA -0.38 -6.96 -0.36 1.9e-11 Dilated cardiomyopathy; CRC cis rs921968 0.643 rs3845836 chr2:219504955 C/T cg02176678 chr2:219576539 TTLL4 0.51 8.55 0.43 4.87e-16 Mean corpuscular hemoglobin concentration; CRC cis rs7666738 1.000 rs13116475 chr4:99054843 C/T cg05340658 chr4:99064831 C4orf37 -0.48 -6.77 -0.35 5.98e-11 Colonoscopy-negative controls vs population controls; CRC cis rs6570726 0.935 rs452552 chr6:145820781 G/A cg05347473 chr6:146136440 FBXO30 0.37 6.0 0.31 5.27e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs875971 0.830 rs778715 chr7:65849209 C/T cg18876405 chr7:65276391 NA 0.51 8.56 0.43 4.3e-16 Aortic root size; CRC cis rs875971 1.000 rs6961990 chr7:65888570 C/A cg11764359 chr7:65958608 NA 0.62 9.99 0.48 1.05e-20 Aortic root size; CRC cis rs10256972 0.706 rs4285396 chr7:1123738 A/G cg07092213 chr7:1199455 ZFAND2A -0.42 -5.84 -0.31 1.27e-8 Longevity;Endometriosis; CRC cis rs4666002 0.665 rs2305929 chr2:28113911 A/G cg27432699 chr2:27873401 GPN1 0.55 6.21 0.32 1.58e-9 Phospholipid levels (plasma); CRC cis rs4731207 0.698 rs3815221 chr7:124481245 G/A cg23710748 chr7:124431027 NA 0.38 6.08 0.32 3.42e-9 Cutaneous malignant melanoma; CRC cis rs9399135 0.967 rs13191501 chr6:135366880 T/C cg22676075 chr6:135203613 NA 0.38 5.86 0.31 1.11e-8 Red blood cell count; CRC cis rs2625529 0.652 rs11072350 chr15:72464609 T/G cg16672083 chr15:72433130 SENP8 0.41 6.23 0.32 1.44e-9 Red blood cell count; CRC cis rs9796 0.870 rs3214068 chr15:41313064 C/G cg18705301 chr15:41695430 NDUFAF1 -0.36 -6.03 -0.32 4.3e-9 Menopause (age at onset); CRC cis rs61008539 0.586 rs6959154 chr7:856320 C/T cg15782153 chr7:917662 C7orf20 0.46 7.34 0.38 1.71e-12 Perceived unattractiveness to mosquitoes; CRC cis rs13118159 0.872 rs1882105 chr4:1345956 T/C cg16405210 chr4:1374714 KIAA1530 -0.55 -7.59 -0.39 3.43e-13 Longevity; CRC cis rs4499344 0.633 rs259256 chr19:33151802 C/T cg08127369 chr19:33164662 ANKRD27 0.39 5.83 0.31 1.31e-8 Mean platelet volume; CRC cis rs4713118 0.869 rs9366700 chr6:27696951 C/T cg08798685 chr6:27730294 NA -0.42 -6.26 -0.33 1.23e-9 Parkinson's disease; CRC cis rs17608059 0.518 rs4792436 chr17:13972307 T/A cg11395062 chr17:14139857 CDRT15 -0.61 -10.35 -0.5 6.3e-22 Temperament; CRC cis rs4481887 0.893 rs1934544 chr1:248505582 G/A cg00666640 chr1:248458726 OR2T12 0.49 9.13 0.45 6.88e-18 Common traits (Other); CRC cis rs9311474 1.000 rs7614727 chr3:52295895 C/T cg15147215 chr3:52552868 STAB1 -0.64 -10.9 -0.52 7.88e-24 Electroencephalogram traits; CRC cis rs11229555 0.645 rs7947248 chr11:58197750 C/T cg15696309 chr11:58395628 NA -0.9 -11.45 -0.53 8.8e-26 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; CRC cis rs9322193 0.923 rs11155671 chr6:149972132 G/A cg13206674 chr6:150067644 NUP43 0.65 9.75 0.47 6.68e-20 Lung cancer; CRC cis rs5750830 0.594 rs5757650 chr22:39778419 A/G cg05872129 chr22:39784769 NA -0.59 -10.47 -0.5 2.53e-22 Intelligence (multi-trait analysis); CRC cis rs473651 0.935 rs515412 chr2:239345394 A/T cg18131467 chr2:239335373 ASB1 1.0 21.49 0.76 1.31e-64 Multiple system atrophy; CRC cis rs11098499 0.866 rs12510451 chr4:120289143 C/T cg24375607 chr4:120327624 NA 0.48 7.48 0.38 6.72e-13 Corneal astigmatism; CRC cis rs8067545 0.611 rs2703786 chr17:20156369 T/C cg13482628 chr17:19912719 NA -0.48 -7.59 -0.39 3.33e-13 Schizophrenia; CRC cis rs9303401 0.659 rs62081315 chr17:56781468 T/C cg02118635 chr17:56770003 RAD51C;TEX14 0.79 10.13 0.49 3.5e-21 Cognitive test performance; CRC cis rs9486719 1.000 rs6923212 chr6:97061940 A/G cg06623918 chr6:96969491 KIAA0776 -0.81 -9.53 -0.47 3.47e-19 Migraine;Coronary artery disease; CRC cis rs16830122 0.514 rs67849779 chr1:154611208 G/A cg24304309 chr1:154577895 ADAR -0.56 -8.18 -0.41 6.35e-15 Alzheimer's disease in APOE e4- carriers; CRC cis rs7044106 0.791 rs2416799 chr9:123480866 G/T cg09586646 chr9:123605570 PSMD5;LOC253039 0.66 9.79 0.47 4.99e-20 Hip circumference adjusted for BMI; CRC cis rs13191362 1.000 rs35044651 chr6:163004142 G/A cg06582575 chr6:163149167 PACRG;PARK2 0.77 10.56 0.5 1.2e-22 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs7412746 0.611 rs11204726 chr1:150743492 T/C cg18016565 chr1:150552671 MCL1 0.43 5.95 0.31 6.7e-9 Melanoma; CRC trans rs9929218 0.954 rs12596834 chr16:68823199 T/C cg04657470 chr2:198365150 HSPE1;HSPD1 -0.77 -11.19 -0.53 7.43e-25 Colorectal cancer; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg23885884 chr7:135242577 NUP205 0.44 6.23 0.32 1.42e-9 Response to antipsychotic treatment; CRC cis rs763121 0.853 rs5750649 chr22:39036769 T/C cg06544989 chr22:39130855 UNC84B 0.46 7.37 0.38 1.4e-12 Menopause (age at onset); CRC cis rs6570726 0.967 rs365515 chr6:145802833 C/T cg05347473 chr6:146136440 FBXO30 -0.38 -5.92 -0.31 8.12e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs35306767 0.714 rs66797613 chr10:1090469 C/T cg20503657 chr10:835505 NA 0.83 9.88 0.48 2.57e-20 Eosinophil percentage of granulocytes; CRC cis rs12230513 0.732 rs7294659 chr12:55866519 T/C cg19537932 chr12:55886519 OR6C68 -0.71 -9.07 -0.45 1.07e-17 Contrast sensitivity; CRC cis rs7618915 0.501 rs34754793 chr3:52629177 A/T cg05573699 chr3:52720067 GNL3;PBRM1 -0.47 -6.96 -0.36 1.87e-11 Bipolar disorder; CRC cis rs1499614 1.000 rs2659913 chr7:66157336 T/A cg18252515 chr7:66147081 NA -1.24 -14.6 -0.63 1.48e-37 Gout; CRC cis rs9303401 0.659 rs35928756 chr17:56702652 C/T cg02118635 chr17:56770003 RAD51C;TEX14 0.79 9.9 0.48 2.16e-20 Cognitive test performance; CRC cis rs7635838 0.619 rs347614 chr3:11276399 T/C cg00170343 chr3:11313890 ATG7 0.55 8.31 0.42 2.56e-15 HDL cholesterol; CRC cis rs9420 0.809 rs11600169 chr11:57464945 T/A cg23127183 chr11:57508653 C11orf31 -0.53 -7.17 -0.37 5.1e-12 Schizophrenia; CRC cis rs7224685 0.569 rs7221595 chr17:4007594 C/T cg05562828 chr17:3906858 NA -0.47 -5.68 -0.3 2.9e-8 Type 2 diabetes; CRC cis rs9420 0.961 rs11602109 chr11:57435296 G/A cg23127183 chr11:57508653 C11orf31 -0.53 -7.17 -0.37 4.95e-12 Schizophrenia; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg07243103 chr16:699355 WDR90 0.53 7.37 0.38 1.37e-12 Anxiety disorder; CRC cis rs4642101 0.618 rs9877079 chr3:12821287 A/G cg24848339 chr3:12840334 CAND2 0.34 6.35 0.33 6.98e-10 QRS complex (12-leadsum); CRC cis rs7259376 0.936 rs12983542 chr19:22590585 C/G cg02657401 chr19:22469223 NA 0.32 6.88 0.35 3e-11 Menopause (age at onset); CRC cis rs534126 1.000 rs9918515 chr7:142922662 C/T cg04039957 chr7:143013207 CLCN1 -0.34 -6.14 -0.32 2.37e-9 Cancer; CRC cis rs10782582 0.593 rs11163967 chr1:76154185 T/C cg03433033 chr1:76189801 ACADM -0.43 -6.23 -0.33 1.39e-9 Daytime sleep phenotypes; CRC cis rs317689 0.788 rs317679 chr12:69693172 A/C cg20891283 chr12:69753455 YEATS4 0.47 6.08 0.32 3.37e-9 Response to diuretic therapy; CRC cis rs10208940 0.920 rs28361349 chr2:68785579 G/A cg12452813 chr2:68675892 NA 0.47 5.95 0.31 6.88e-9 Urate levels in lean individuals; CRC trans rs7937682 0.883 rs529529 chr11:111461128 C/T cg18187862 chr3:45730750 SACM1L 0.43 6.14 0.32 2.38e-9 Primary sclerosing cholangitis; CRC cis rs9463078 0.605 rs13216116 chr6:44936681 C/T cg25276700 chr6:44698697 NA 0.24 5.89 0.31 9.66e-9 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; CRC cis rs8072100 0.666 rs9913014 chr17:45460189 C/T cg25173405 chr17:45401733 C17orf57 -0.44 -6.56 -0.34 2.1e-10 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs2200578 1.000 rs12053519 chr2:99875018 G/A cg26064155 chr2:99771622 LIPT1;TSGA10 0.56 6.44 0.33 4.14e-10 IgG glycosylation; CRC cis rs4363385 0.747 rs10788850 chr1:152963932 A/T cg25856811 chr1:152973957 SPRR3 -0.27 -7.53 -0.38 5.01e-13 Inflammatory skin disease; CRC cis rs853679 0.546 rs200954 chr6:27838764 C/G cg26587870 chr6:27730563 NA -0.6 -5.91 -0.31 8.73e-9 Depression; CRC cis rs10504229 0.775 rs56155911 chr8:58163247 C/T cg21724239 chr8:58056113 NA 0.65 8.46 0.42 8.64e-16 Developmental language disorder (linguistic errors); CRC cis rs10504229 0.610 rs6999661 chr8:58127391 C/G cg04204079 chr8:58130323 NA -0.45 -5.78 -0.3 1.71e-8 Developmental language disorder (linguistic errors); CRC cis rs1799949 1.000 rs2298862 chr17:41176688 T/C cg01879757 chr17:41196368 BRCA1 -0.41 -6.07 -0.32 3.62e-9 Menopause (age at onset); CRC cis rs2243480 1.000 rs2257790 chr7:65600450 C/T cg25985355 chr7:65971099 NA -0.52 -5.98 -0.31 5.86e-9 Diabetic kidney disease; CRC cis rs801193 0.935 rs11772264 chr7:66176387 T/C cg00343986 chr7:65444356 GUSB 0.48 7.08 0.36 8.72e-12 Aortic root size; CRC cis rs4481887 0.962 rs10788770 chr1:248457474 T/G cg00666640 chr1:248458726 OR2T12 0.54 9.56 0.47 2.9e-19 Common traits (Other); CRC cis rs11105298 0.891 rs10858896 chr12:89920184 C/T cg00757033 chr12:89920650 WDR51B 0.37 6.08 0.32 3.37e-9 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; CRC cis rs12142240 0.660 rs72885163 chr1:46807117 C/A cg14993813 chr1:46806288 NSUN4 -0.49 -6.23 -0.32 1.43e-9 Menopause (age at onset); CRC cis rs896854 0.684 rs10099059 chr8:95986972 G/C cg16049864 chr8:95962084 TP53INP1 -0.64 -11.74 -0.54 7.81e-27 Type 2 diabetes; CRC cis rs651907 0.535 rs34263427 chr3:101507805 A/G cg11279151 chr3:101281821 RG9MTD1 -0.53 -7.07 -0.36 9.18e-12 Colorectal cancer; CRC cis rs1862618 0.671 rs28397234 chr5:56248428 T/G cg12311346 chr5:56204834 C5orf35 0.66 10.11 0.49 4.1e-21 Initial pursuit acceleration; CRC trans rs7859245 1.000 rs7873626 chr9:138490710 C/T cg14410503 chr7:47343076 TNS3 0.36 6.0 0.31 5.07e-9 Response to paliperidone in schizophrenia (negative Marder score); CRC cis rs3806843 1.000 rs4404730 chr5:140162610 G/A cg19875535 chr5:140030758 IK 0.56 9.01 0.45 1.66e-17 Depressive symptoms (multi-trait analysis); CRC cis rs7191439 0.858 rs11076702 chr16:88774569 A/C cg27087555 chr16:88793112 FAM38A -1.38 -11.7 -0.54 1.1e-26 Plateletcrit; CRC cis rs9868809 0.772 rs34096717 chr3:48719453 A/C cg07636037 chr3:49044803 WDR6 -0.64 -6.05 -0.32 4e-9 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; CRC cis rs9814567 1.000 rs7374325 chr3:134275601 G/C cg06109529 chr3:134205091 CEP63;ANAPC13 -0.82 -12.36 -0.56 4.36e-29 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs7847628 0.566 rs10739575 chr9:123606101 A/G cg09586646 chr9:123605570 PSMD5;LOC253039 -0.64 -6.69 -0.35 9.48e-11 Birth weight; CRC cis rs45509595 0.659 rs390764 chr6:27782535 C/T cg23259851 chr6:27775964 HIST1H2AI;HIST1H2BL 0.71 5.93 0.31 7.74e-9 Breast cancer; CRC trans rs561341 1.000 rs484175 chr17:30309041 G/A cg27661571 chr11:113659931 NA -0.95 -11.14 -0.52 1.11e-24 Hip circumference adjusted for BMI; CRC trans rs10983614 1.000 rs7867776 chr9:120072627 A/G cg03909902 chr12:108154529 PRDM4 0.44 6.11 0.32 2.77e-9 Survival in pancreatic cancer; CRC cis rs9486715 0.867 rs926277 chr6:96868837 T/A cg18709589 chr6:96969512 KIAA0776 0.47 7.01 0.36 1.34e-11 Headache; CRC cis rs634534 0.532 rs12794370 chr11:65770413 G/A cg26695010 chr11:65641043 EFEMP2 -0.4 -6.07 -0.32 3.48e-9 Sum eosinophil basophil counts;Eosinophil counts; CRC cis rs826838 0.967 rs6580726 chr12:39108623 T/C cg13010199 chr12:38710504 ALG10B -0.4 -5.9 -0.31 8.82e-9 Heart rate; CRC cis rs881375 0.678 rs10760130 chr9:123701990 G/A cg14255062 chr9:123606675 PSMD5;LOC253039 0.39 6.15 0.32 2.23e-9 Rheumatoid arthritis; CRC cis rs1707322 0.896 rs946528 chr1:46485562 C/T cg06784218 chr1:46089804 CCDC17 -0.53 -9.5 -0.46 4.54e-19 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs9467711 0.538 rs9467626 chr6:25873746 C/A cg08501292 chr6:25962987 TRIM38 1.1 9.57 0.47 2.57e-19 Autism spectrum disorder or schizophrenia; CRC cis rs1215050 0.740 rs783936 chr4:98928628 G/T cg05340658 chr4:99064831 C4orf37 -0.47 -7.07 -0.36 9.24e-12 Waist-to-hip ratio adjusted for body mass index; CRC cis rs597539 0.652 rs482172 chr11:68668437 C/A cg06028808 chr11:68637592 NA 0.42 6.65 0.34 1.19e-10 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs7615952 0.599 rs2333408 chr3:125732098 G/A cg04553112 chr3:125709451 NA -0.49 -6.07 -0.32 3.5e-9 Blood pressure (smoking interaction); CRC cis rs2012796 1.000 rs10450939 chr14:81825202 A/T cg02996355 chr14:81879375 NA 0.51 7.61 0.39 2.89e-13 Night sleep phenotypes; CRC trans rs1814175 0.817 rs2866545 chr11:49630824 A/C cg03929089 chr4:120376271 NA -0.95 -17.98 -0.7 8.09e-51 Height; CRC cis rs1552244 0.554 rs55847233 chr3:9991101 C/G cg02579736 chr3:10068473 FANCD2;CIDECP 0.62 9.03 0.45 1.53e-17 Alzheimer's disease; CRC cis rs892961 0.899 rs8071024 chr17:75414067 T/C cg05865280 chr17:75406074 SEPT9 0.62 14.27 0.62 2.79e-36 Airflow obstruction; CRC trans rs6600671 1.000 rs2185281 chr1:121179991 A/G cg09829573 chr1:144692074 NBPF9 -0.41 -6.11 -0.32 2.87e-9 Hip geometry; CRC cis rs1003719 0.788 rs1155787 chr21:38448069 G/A cg10648535 chr21:38446584 PIGP;TTC3 0.53 7.53 0.38 4.88e-13 Eye color traits; CRC cis rs1524976 1.000 rs1554664 chr3:65501649 A/G cg16238336 chr3:65465873 MAGI1 0.49 6.35 0.33 7.31e-10 PR interval; CRC cis rs7618501 0.633 rs6792892 chr3:49995518 T/C cg24308560 chr3:49941425 MST1R -0.51 -8.26 -0.41 3.52e-15 Intelligence (multi-trait analysis); CRC cis rs10751667 0.714 rs7396700 chr11:963863 A/C cg23136738 chr11:925521 AP2A2 -0.42 -7.09 -0.36 8.19e-12 Alzheimer's disease (late onset); CRC cis rs933688 1.000 rs11950530 chr5:90688740 A/G cg26981201 chr5:90679533 LOC100129716;ARRDC3 1.02 15.59 0.65 1.97e-41 Smoking behavior; CRC cis rs17095355 1.000 rs11194933 chr10:111725862 T/C cg00817464 chr10:111662876 XPNPEP1 -0.61 -8.38 -0.42 1.55e-15 Biliary atresia; CRC cis rs9611565 0.659 rs4822034 chr22:41931010 T/C cg03806693 chr22:41940476 POLR3H -1.12 -14.99 -0.64 4.54e-39 Vitiligo; CRC trans rs4689592 0.503 rs2292461 chr4:7058473 C/T cg07817883 chr1:32538562 TMEM39B -0.66 -7.75 -0.39 1.18e-13 Monocyte percentage of white cells; CRC cis rs4332037 0.950 rs62442895 chr7:1936938 G/A cg02421172 chr7:1938701 MAD1L1 0.44 5.9 0.31 9.26e-9 Bipolar disorder; CRC cis rs9916302 0.645 rs1053651 chr17:37822311 A/C cg07936489 chr17:37558343 FBXL20 -0.53 -7.88 -0.4 4.76e-14 Glomerular filtration rate (creatinine); CRC cis rs2991971 0.810 rs2356413 chr1:45914048 A/T cg24296786 chr1:45957014 TESK2 -0.5 -7.4 -0.38 1.17e-12 High light scatter reticulocyte count; CRC cis rs9814567 1.000 rs7371896 chr3:134249769 C/G cg06541857 chr3:134203789 ANAPC13;CEP63 -0.4 -6.01 -0.31 4.81e-9 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs2880765 0.743 rs7168345 chr15:86013601 A/G cg17133734 chr15:86042851 AKAP13 -0.4 -6.21 -0.32 1.64e-9 Coronary artery disease; CRC cis rs7408868 1.000 rs757472 chr19:15273221 T/C cg14696996 chr19:15285081 NOTCH3 0.65 6.58 0.34 1.8e-10 Pulse pressure; CRC cis rs4481887 0.893 rs28451623 chr1:248509783 G/A cg00666640 chr1:248458726 OR2T12 0.48 8.99 0.44 2.05e-17 Common traits (Other); CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg18891615 chr8:101962925 YWHAZ 0.39 6.3 0.33 9.36e-10 Obesity-related traits; CRC cis rs853679 0.517 rs17774663 chr6:28120898 G/A cg12273811 chr6:28175739 NA 0.73 9.16 0.45 5.8e-18 Depression; CRC cis rs17162190 0.698 rs4659444 chr1:26825116 C/T cg17456097 chr1:26900765 RPS6KA1 0.46 6.66 0.34 1.15e-10 Mean corpuscular volume; CRC cis rs561341 1.000 rs537166 chr17:30326827 C/T cg00745463 chr17:30367425 LRRC37B -0.7 -8.39 -0.42 1.42e-15 Hip circumference adjusted for BMI; CRC cis rs6495122 0.651 rs11636952 chr15:75114322 T/C cg14664628 chr15:75095509 CSK -0.75 -12.55 -0.57 8.48e-30 Caffeine consumption;Diastolic blood pressure;Coffee consumption; CRC cis rs561341 0.941 rs4795664 chr17:30233467 C/T cg13647721 chr17:30228624 UTP6 0.57 5.65 0.3 3.4e-8 Hip circumference adjusted for BMI; CRC cis rs1552244 0.626 rs2886396 chr3:10037670 C/T cg08888203 chr3:10149979 C3orf24 0.62 8.3 0.42 2.65e-15 Alzheimer's disease; CRC cis rs2404602 0.679 rs12900494 chr15:76912504 A/G cg22467129 chr15:76604101 ETFA -0.38 -6.33 -0.33 8.22e-10 Blood metabolite levels; CRC cis rs1799949 0.896 rs8176086 chr17:41274778 G/A cg05368731 chr17:41323189 NBR1 0.69 10.48 0.5 2.33e-22 Menopause (age at onset); CRC cis rs9733 0.596 rs1136808 chr1:150702717 G/C cg17724175 chr1:150552817 MCL1 0.57 9.12 0.45 7.76e-18 Tonsillectomy; CRC cis rs4478858 0.660 rs10798844 chr1:31819128 A/G cg07478791 chr1:31886160 SERINC2 -0.41 -5.65 -0.3 3.39e-8 Alcohol dependence; CRC cis rs7091068 0.616 rs7920366 chr10:95497178 A/T cg20715218 chr10:95462985 C10orf4 0.54 5.68 0.3 2.98e-8 Urinary tract infection frequency; CRC cis rs7208859 0.673 rs17826219 chr17:29161845 G/A cg01831904 chr17:28903510 LRRC37B2 -0.55 -5.75 -0.3 2.01e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs250677 0.687 rs42364 chr5:148438858 T/A cg18129178 chr5:148520854 ABLIM3 -0.37 -5.68 -0.3 2.91e-8 Breast cancer; CRC cis rs17253792 0.822 rs113692713 chr14:56087424 C/T cg24579896 chr14:56047964 C14orf33;KTN1 0.71 5.68 0.3 2.98e-8 Putamen volume; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg09463466 chr15:77925892 LINGO1 0.42 6.97 0.36 1.76e-11 Liver disease severity in Alagille syndrome; CRC cis rs2404602 0.692 rs55676827 chr15:76961716 C/T cg03037974 chr15:76606532 NA 0.7 12.57 0.57 7.07e-30 Blood metabolite levels; CRC cis rs6860806 0.507 rs272880 chr5:131670178 C/T cg09877947 chr5:131593287 PDLIM4 0.44 7.22 0.37 3.67e-12 Breast cancer; CRC cis rs2075371 0.796 rs35440439 chr7:134006094 C/T cg20476274 chr7:133979776 SLC35B4 0.66 10.76 0.51 2.5e-23 Mean platelet volume; CRC trans rs7939886 0.920 rs11231901 chr11:55811529 A/G cg03929089 chr4:120376271 NA 0.67 6.12 0.32 2.69e-9 Myopia (pathological); CRC trans rs3733585 0.673 rs7375587 chr4:9954758 A/T cg26043149 chr18:55253948 FECH 0.46 7.05 0.36 1.05e-11 Cleft plate (environmental tobacco smoke interaction); CRC cis rs10779751 1.000 rs1064261 chr1:11288758 C/T cg08854313 chr1:11322531 MTOR 0.65 9.03 0.45 1.48e-17 Body mass index; CRC cis rs1256061 0.624 rs1760988 chr14:64696813 A/G cg23250157 chr14:64679961 SYNE2 0.46 7.14 0.37 6.03e-12 Hemoglobin concentration;Red blood cell count;Hematocrit; CRC cis rs9393692 0.905 rs6908328 chr6:26292855 C/A cg00631329 chr6:26305371 NA -0.7 -13.51 -0.6 2.24e-33 Educational attainment; CRC cis rs9611565 0.840 rs4822025 chr22:41776646 C/G cg06634786 chr22:41940651 POLR3H -0.65 -7.51 -0.38 5.62e-13 Vitiligo; CRC cis rs11083475 0.681 rs62121377 chr19:39257296 G/A cg26703956 chr19:39260304 NA -0.38 -6.11 -0.32 2.83e-9 Heart rate; CRC cis rs1862618 0.853 rs190414 chr5:56116772 C/A cg03609598 chr5:56110824 MAP3K1 -0.83 -10.3 -0.49 9.59e-22 Initial pursuit acceleration; CRC cis rs2228479 0.717 rs11644967 chr16:89806614 T/A cg19635926 chr16:89946313 TCF25 0.66 6.88 0.35 3.09e-11 Skin colour saturation; CRC cis rs4665809 0.590 rs10495756 chr2:26485586 A/G cg25036284 chr2:26402008 FAM59B 0.62 7.86 0.4 5.64e-14 Gut microbiome composition (summer); CRC cis rs274567 0.501 rs274571 chr5:131712125 A/G cg12564285 chr5:131593104 PDLIM4 -0.46 -7.74 -0.39 1.23e-13 Blood metabolite levels; CRC cis rs6684514 0.961 rs72710222 chr1:156285995 T/C cg16558208 chr1:156270281 VHLL 0.57 8.84 0.44 5.99e-17 Mean corpuscular hemoglobin concentration;Glycated hemoglobin levels; CRC cis rs769267 0.965 rs1469712 chr19:19528821 C/A cg02546618 chr19:19431379 KIAA0892;SF4 0.45 6.23 0.32 1.44e-9 Tonsillectomy; CRC cis rs7789940 0.904 rs7459185 chr7:75934640 C/G cg10167463 chr7:75959203 YWHAG 0.66 9.3 0.46 1.96e-18 Multiple sclerosis; CRC cis rs7208859 0.623 rs216439 chr17:28927884 T/C cg13385521 chr17:29058706 SUZ12P 0.58 6.35 0.33 7.04e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs701145 0.556 rs355763 chr3:154012881 C/T cg16511985 chr3:153974050 SGEF 0.43 5.73 0.3 2.25e-8 Coronary artery disease; CRC trans rs2048656 0.605 rs13249234 chr8:9650401 T/C cg08975724 chr8:8085496 FLJ10661 0.46 6.52 0.34 2.61e-10 Schizophrenia; CRC cis rs9560113 1.000 rs9560106 chr13:112179605 A/G cg10483660 chr13:112241077 NA 0.34 5.65 0.3 3.52e-8 Menarche (age at onset); CRC cis rs4588572 0.643 rs2012562 chr5:77768088 T/A cg11547950 chr5:77652471 NA -0.52 -7.12 -0.37 6.73e-12 Triglycerides; CRC cis rs79387448 0.638 rs76255660 chr2:103091028 T/C cg00507830 chr2:103233733 NA 0.58 5.93 0.31 7.65e-9 Gut microbiota (bacterial taxa); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg05977900 chr3:182512126 ATP11B 0.49 6.87 0.35 3.27e-11 Response to antipsychotic treatment; CRC cis rs2204008 0.563 rs2320512 chr12:38266913 G/A cg26384229 chr12:38710491 ALG10B -0.52 -7.57 -0.39 3.8e-13 Bladder cancer; CRC cis rs7772486 0.754 rs702323 chr6:146008274 A/G cg13319975 chr6:146136371 FBXO30 0.43 6.29 0.33 9.84e-10 Lobe attachment (rater-scored or self-reported); CRC cis rs7762018 0.943 rs11546265 chr6:170108363 G/A cg24289452 chr6:170231220 NA -0.6 -6.56 -0.34 2.12e-10 Thiazide-induced adverse metabolic effects in hypertensive patients; CRC trans rs1728785 1.000 rs1645979 chr16:68603660 G/T cg04657470 chr2:198365150 HSPE1;HSPD1 0.74 8.69 0.43 1.71e-16 Ulcerative colitis; CRC cis rs11148252 0.583 rs9536048 chr13:52958788 T/C cg12458913 chr13:53173898 NA 0.49 6.6 0.34 1.67e-10 Lewy body disease; CRC cis rs8177179 0.967 rs10935085 chr3:133459735 C/T cg16262614 chr3:133464971 TF 0.5 9.49 0.46 4.83e-19 Iron status biomarkers (transferrin levels); CRC cis rs2625529 0.652 rs8027164 chr15:72407733 A/T cg16672083 chr15:72433130 SENP8 0.45 6.85 0.35 3.53e-11 Red blood cell count; CRC trans rs3780486 0.846 rs3780487 chr9:33139237 T/C cg20290983 chr6:43655470 MRPS18A 1.18 27.1 0.83 7.82e-86 IgG glycosylation; CRC cis rs7666738 0.830 rs10010698 chr4:98981594 C/T cg17366294 chr4:99064904 C4orf37 0.43 7.21 0.37 3.91e-12 Colonoscopy-negative controls vs population controls; CRC cis rs7833986 0.534 rs2976022 chr8:57007843 T/G cg23139584 chr8:56987506 RPS20;SNORD54 0.91 12.38 0.56 3.79e-29 Height; CRC cis rs9921222 0.521 rs78867928 chr16:368986 C/T cg00101154 chr16:420108 MRPL28 -0.61 -7.82 -0.4 7.43e-14 Bone mineral density (spine);Bone mineral density; CRC cis rs78456975 1.000 rs11883965 chr2:1560062 T/C cg26248373 chr2:1572462 NA -0.66 -7.21 -0.37 3.97e-12 Placebo response in major depressive disorder (% change in symptom score); CRC cis rs477895 0.838 rs12794145 chr11:64006484 C/T cg18225595 chr11:63971243 STIP1 0.62 7.83 0.4 6.92e-14 Mean platelet volume; CRC cis rs7264396 0.623 rs78949029 chr20:34384964 C/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.43 -5.9 -0.31 9.12e-9 Total cholesterol levels; CRC cis rs1832871 0.672 rs9457363 chr6:158777515 C/T cg07165851 chr6:158734300 TULP4 0.61 7.69 0.39 1.69e-13 Height; CRC cis rs9611565 0.659 rs9611603 chr22:41912750 A/G cg06481639 chr22:41940642 POLR3H -0.54 -6.3 -0.33 9.65e-10 Vitiligo; CRC trans rs11098499 0.863 rs1552092 chr4:120488496 C/T cg25214090 chr10:38739885 LOC399744 0.66 10.39 0.5 4.71e-22 Corneal astigmatism; CRC trans rs2710642 0.888 rs2539985 chr2:63134507 T/A cg05376469 chr2:102649931 NA -0.38 -6.05 -0.32 3.96e-9 LDL cholesterol levels;LDL cholesterol; CRC cis rs228769 0.543 rs170634 chr17:42175821 C/A cg19774624 chr17:42201019 HDAC5 0.54 7.45 0.38 8.16e-13 Bone mineral density (hip);Bone mineral density (spine); CRC cis rs769267 1.000 rs769267 chr19:19446936 A/G cg02546618 chr19:19431379 KIAA0892;SF4 0.43 5.98 0.31 5.78e-9 Tonsillectomy; CRC cis rs73206853 0.686 rs73194021 chr12:111131893 G/A cg12870014 chr12:110450643 ANKRD13A 0.65 6.07 0.32 3.62e-9 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC cis rs12143943 0.835 rs12730457 chr1:204548132 C/A cg17419461 chr1:204415978 PIK3C2B 0.42 6.47 0.34 3.5e-10 Cognitive performance; CRC cis rs2404602 0.583 rs12907668 chr15:76589767 A/T cg23625390 chr15:77176239 SCAPER 0.39 5.61 0.3 4.21e-8 Blood metabolite levels; CRC cis rs2066819 1.000 rs59811639 chr12:56695954 C/T cg26714650 chr12:56694279 CS -1.38 -11.56 -0.54 3.59e-26 Psoriasis vulgaris; CRC cis rs11958404 0.789 rs72800604 chr5:157502940 C/T cg05962755 chr5:157440814 NA 1.04 12.82 0.58 8.27e-31 IgG glycosylation; CRC cis rs2688608 0.592 rs11814282 chr10:75490217 T/C cg23231163 chr10:75533350 FUT11 -0.37 -5.9 -0.31 9.05e-9 Inflammatory bowel disease; CRC cis rs10504229 0.728 rs72650855 chr8:58152570 A/G cg11062466 chr8:58055876 NA 0.45 6.11 0.32 2.74e-9 Developmental language disorder (linguistic errors); CRC cis rs12479064 0.724 rs112900993 chr2:99948805 C/G cg26064155 chr2:99771622 LIPT1;TSGA10 -0.63 -7.44 -0.38 8.92e-13 Chronic sinus infection; CRC cis rs1862618 0.573 rs2034245 chr5:56243685 T/C cg20203395 chr5:56204925 C5orf35 0.8 10.02 0.48 8.68e-21 Initial pursuit acceleration; CRC cis rs7072216 0.763 rs10732782 chr10:100166506 C/A cg26618903 chr10:100175079 PYROXD2 -0.55 -9.26 -0.45 2.73e-18 Metabolite levels; CRC cis rs11105298 0.891 rs10858899 chr12:89923811 G/C cg08166232 chr12:89918718 WDR51B;GALNT4 -0.62 -7.9 -0.4 4.15e-14 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg06488666 chr20:33104140 DYNLRB1 0.47 6.58 0.34 1.87e-10 Response to antipsychotic treatment; CRC cis rs6860806 0.507 rs272868 chr5:131680751 C/G cg24060327 chr5:131705240 SLC22A5 -0.5 -7.51 -0.38 5.56e-13 Breast cancer; CRC cis rs7197653 0.748 rs8060690 chr16:68340085 G/T cg09835421 chr16:68378352 PRMT7 -0.81 -8.16 -0.41 7.17e-15 Magnesium levels; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg17841529 chr12:76953712 OSBPL8 0.48 7.0 0.36 1.4e-11 Intelligence (multi-trait analysis); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg18766056 chr1:39457186 AKIRIN1 0.4 6.52 0.34 2.69e-10 Liver disease severity in Alagille syndrome; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg16436711 chr6:27173574 NA 0.21 6.06 0.32 3.81e-9 Liver disease severity in Alagille syndrome; CRC cis rs10504229 0.775 rs17805026 chr8:58160637 A/C cg08219700 chr8:58056026 NA 0.46 5.72 0.3 2.37e-8 Developmental language disorder (linguistic errors); CRC cis rs10754283 0.967 rs6428559 chr1:90099036 C/T cg21401794 chr1:90099060 LRRC8C 0.43 6.14 0.32 2.37e-9 Amyotrophic lateral sclerosis (sporadic); CRC cis rs6860806 0.661 rs3763112 chr5:131586480 A/G cg02033258 chr5:131593261 PDLIM4 0.4 7.63 0.39 2.57e-13 Breast cancer; CRC cis rs7264396 0.790 rs6579255 chr20:34219496 T/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.62 -10.09 -0.49 5.04e-21 Total cholesterol levels; CRC trans rs951252 0.504 rs11734405 chr4:146081096 C/T cg13406896 chr2:10220712 CYS1 0.36 6.5 0.34 2.95e-10 Hip circumference; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg01301935 chr16:69599904 NFAT5;MIR1538 0.48 6.63 0.34 1.4e-10 Response to antipsychotic treatment; CRC cis rs703842 0.616 rs1875125 chr12:58227241 T/G cg00677455 chr12:58241039 CTDSP2 0.82 11.69 0.54 1.23e-26 Multiple sclerosis; CRC cis rs9361491 0.657 rs7766318 chr6:79451515 A/C cg05283184 chr6:79620031 NA -0.38 -5.73 -0.3 2.28e-8 Intelligence (multi-trait analysis); CRC cis rs7618501 0.633 rs7621026 chr3:49975334 A/G cg24110177 chr3:50126178 RBM5 -0.49 -7.54 -0.38 4.68e-13 Intelligence (multi-trait analysis); CRC cis rs2991971 0.967 rs2356551 chr1:46009318 C/T cg03123370 chr1:45965343 CCDC163P;MMACHC -0.37 -5.68 -0.3 2.99e-8 High light scatter reticulocyte count; CRC cis rs12142240 0.660 rs112560929 chr1:46822297 A/G cg14993813 chr1:46806288 NSUN4 -0.49 -6.22 -0.32 1.55e-9 Menopause (age at onset); CRC cis rs11148252 0.774 rs6561666 chr13:52930045 A/G cg12458913 chr13:53173898 NA 0.53 8.47 0.42 8.13e-16 Lewy body disease; CRC cis rs9303401 1.000 rs9904677 chr17:56873025 A/G cg02118635 chr17:56770003 RAD51C;TEX14 0.55 8.16 0.41 6.95e-15 Cognitive test performance; CRC cis rs7208859 0.623 rs7208088 chr17:29143667 C/T cg01831904 chr17:28903510 LRRC37B2 -0.63 -6.5 -0.34 3.04e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs8060686 0.920 rs1124324 chr16:67897487 C/T cg08314208 chr16:67682810 RLTPR -0.6 -6.91 -0.36 2.6e-11 HDL cholesterol;Metabolic syndrome; CRC cis rs9611565 0.659 rs28623192 chr22:41940524 A/G cg03806693 chr22:41940476 POLR3H -1.13 -15.26 -0.64 3.98e-40 Vitiligo; CRC cis rs230203 0.506 rs230196 chr20:55775623 C/A cg13236649 chr20:55835020 BMP7 0.38 5.63 0.3 3.83e-8 Monobrow; CRC cis rs9467773 0.620 rs2494716 chr6:26662736 T/C cg09904177 chr6:26538194 HMGN4 0.72 11.39 0.53 1.47e-25 Intelligence (multi-trait analysis); CRC cis rs1670533 1.000 rs13134921 chr4:1054177 A/G cg27284194 chr4:1044797 NA 0.5 6.2 0.32 1.66e-9 Recombination rate (females); CRC cis rs524281 0.731 rs2430979 chr11:65813383 C/T cg16950941 chr11:66035639 RAB1B 0.5 6.02 0.31 4.72e-9 Electroencephalogram traits; CRC cis rs727563 0.594 rs132807 chr22:42071584 T/C cg06634786 chr22:41940651 POLR3H 0.61 6.86 0.35 3.38e-11 Crohn's disease;Inflammatory bowel disease; CRC cis rs9914988 0.943 rs7217547 chr17:27106872 C/G cg20469991 chr17:27169893 C17orf63 -0.5 -6.16 -0.32 2.13e-9 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs9527 0.501 rs12244388 chr10:104640052 G/A cg04362960 chr10:104952993 NT5C2 0.62 8.88 0.44 4.55e-17 Arsenic metabolism; CRC cis rs7731657 0.537 rs2905534 chr5:130242005 C/T cg08523029 chr5:130500466 HINT1 -0.47 -6.05 -0.32 3.95e-9 Fasting plasma glucose; CRC cis rs1008375 1.000 rs1860596 chr4:17660082 C/T cg04450456 chr4:17643702 FAM184B 0.36 5.85 0.31 1.2e-8 Parasitemia in Tripanosoma cruzi seropositivity; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg03637447 chr2:99061186 INPP4A 0.47 6.68 0.35 1.04e-10 Response to antipsychotic treatment; CRC cis rs1218582 0.774 rs11264284 chr1:154875793 C/T cg03351412 chr1:154909251 PMVK 0.5 7.72 0.39 1.38e-13 Prostate cancer; CRC cis rs8013055 0.846 rs10147392 chr14:105978537 T/G cg23356831 chr14:105996513 TMEM121 0.42 7.19 0.37 4.4e-12 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis); CRC cis rs798554 1.000 rs798550 chr7:2760609 A/G cg17321639 chr7:2759063 NA -0.54 -7.79 -0.39 8.97e-14 Height; CRC cis rs172166 0.694 rs188105 chr6:28071393 C/T cg20615401 chr6:28092323 ZSCAN16 0.45 5.98 0.31 5.68e-9 Cardiac Troponin-T levels; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg07738077 chr19:53303448 ZNF28 -0.39 -6.23 -0.32 1.41e-9 Liver disease severity in Alagille syndrome; CRC cis rs887829 0.569 rs4663333 chr2:234655303 G/T cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.46 -7.25 -0.37 3e-12 Metabolic traits;Bilirubin levels;Cholelithiasis-related traits in sickle cell anemia;Metabolite levels;Total bilirubin levels in HIV-1 infection;Serum metabolite levels;Blood metabolite levels; CRC cis rs6938 0.534 rs1133322 chr15:75212357 A/G cg05627522 chr15:75251581 NA 0.38 5.89 0.31 9.58e-9 Breast cancer; CRC cis rs3736485 0.844 rs4775943 chr15:51770105 A/G cg08986416 chr15:51914746 DMXL2 -0.46 -6.55 -0.34 2.18e-10 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs7119 0.717 rs12910594 chr15:77817103 G/A cg10437265 chr15:77819839 NA 0.69 12.74 0.57 1.76e-30 Type 2 diabetes; CRC cis rs10504229 1.000 rs67344620 chr8:58187537 C/A cg02725872 chr8:58115012 NA -0.38 -6.43 -0.33 4.44e-10 Developmental language disorder (linguistic errors); CRC cis rs7811142 1.000 rs112317829 chr7:100043173 A/G cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.62 8.34 0.42 2.09e-15 Platelet count; CRC trans rs12599106 0.770 rs12445057 chr16:34970274 C/G cg05064044 chr6:292385 DUSP22 -0.72 -10.17 -0.49 2.57e-21 Menopause (age at onset); CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg22091798 chr11:62446605 UBXN1 0.57 7.67 0.39 1.98e-13 Thyroid stimulating hormone; CRC cis rs3820068 0.603 rs6668726 chr1:15962614 G/A cg24675056 chr1:15929824 NA 0.5 6.81 0.35 4.53e-11 Systolic blood pressure; CRC trans rs11039798 0.512 rs1988465 chr11:49011303 C/T cg03929089 chr4:120376271 NA 0.64 6.42 0.33 4.71e-10 Axial length; CRC cis rs12431939 0.947 rs68180359 chr14:51672027 G/A cg23942311 chr14:51606299 NA -0.57 -6.51 -0.34 2.79e-10 Cancer; CRC trans rs61931739 0.500 rs6488209 chr12:34319309 A/G cg26384229 chr12:38710491 ALG10B 0.51 7.24 0.37 3.24e-12 Morning vs. evening chronotype; CRC cis rs9914988 0.725 rs9905510 chr17:27092325 G/A cg02049041 chr17:27085579 C17orf63 0.44 5.61 0.3 4.31e-8 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs1552244 0.572 rs7645667 chr3:10157337 C/A cg16606324 chr3:10149918 C3orf24 0.7 8.09 0.41 1.19e-14 Alzheimer's disease; CRC cis rs6570726 0.967 rs9403706 chr6:145795187 C/T cg05347473 chr6:146136440 FBXO30 -0.37 -5.78 -0.3 1.69e-8 Lobe attachment (rater-scored or self-reported); CRC cis rs6545883 0.895 rs6545871 chr2:61692203 G/T cg15711740 chr2:61764176 XPO1 -0.45 -5.95 -0.31 6.92e-9 Tuberculosis; CRC cis rs2576037 0.583 rs8098948 chr18:44512332 C/A cg23996704 chr18:44553084 KATNAL2 -0.38 -7.55 -0.38 4.33e-13 Personality dimensions; CRC cis rs2084637 0.965 rs59872663 chr11:122400354 C/T cg21585512 chr11:122030076 LOC399959 -0.4 -7.29 -0.37 2.39e-12 Stroke; CRC cis rs7615952 0.688 rs12638240 chr3:125541238 G/A cg05084668 chr3:125655381 ALG1L -0.42 -5.94 -0.31 7.23e-9 Blood pressure (smoking interaction); CRC cis rs9894429 0.752 rs6565610 chr17:79592652 A/G cg18240062 chr17:79603768 NPLOC4 0.67 11.92 0.55 1.86e-27 Eye color traits; CRC cis rs7666738 0.716 rs11721453 chr4:99045485 G/T cg17366294 chr4:99064904 C4orf37 0.45 7.73 0.39 1.34e-13 Colonoscopy-negative controls vs population controls; CRC cis rs216303 1.000 rs216295 chr12:6154206 C/T cg19878637 chr12:6148451 VWF 0.51 6.27 0.33 1.16e-9 Low vWF levels; CRC cis rs28386778 0.897 rs2584608 chr17:61936710 A/G cg23090583 chr17:61904693 PSMC5;FTSJ3 0.99 18.04 0.71 4.57e-51 Prudent dietary pattern; CRC cis rs6088580 0.634 rs6059896 chr20:33111783 T/C cg08999081 chr20:33150536 PIGU 0.64 11.6 0.54 2.57e-26 Glomerular filtration rate (creatinine); CRC cis rs868943 0.582 rs12203127 chr6:116468315 A/T cg15226275 chr6:116381976 FRK 0.24 5.84 0.31 1.27e-8 Total cholesterol levels; CRC cis rs2019137 0.936 rs3828188 chr2:113954247 G/A cg19083407 chr2:113993142 PAX8;LOC440839;LOC654433 -0.46 -6.45 -0.33 4.04e-10 Lymphocyte counts; CRC cis rs10089 0.953 rs7713860 chr5:127428789 G/T cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.73 10.16 0.49 2.91e-21 Ileal carcinoids; CRC cis rs13118159 0.550 rs28522910 chr4:1374774 C/T cg02018176 chr4:1364513 KIAA1530 0.67 11.63 0.54 2.01e-26 Longevity; CRC cis rs514406 0.668 rs520281 chr1:53365235 G/C cg27535305 chr1:53392650 SCP2 -0.45 -7.98 -0.4 2.46e-14 Monocyte count; CRC cis rs6964587 1.000 rs6964587 chr7:91630620 G/T cg17063962 chr7:91808500 NA 0.8 14.22 0.62 4.28e-36 Breast cancer; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg09273779 chr9:35605990 TESK1 0.52 7.53 0.38 4.89e-13 Response to antipsychotic treatment; CRC cis rs860295 0.812 rs12081192 chr1:155738044 A/G cg02153340 chr1:155202674 NA -0.53 -6.53 -0.34 2.44e-10 Body mass index; CRC cis rs6502050 0.749 rs7209948 chr17:80086804 T/G cg25804541 chr17:80189381 SLC16A3 0.31 5.9 0.31 8.92e-9 Life satisfaction; CRC cis rs798554 0.757 rs2533882 chr7:2846894 G/T cg19346786 chr7:2764209 NA -0.44 -7.52 -0.38 5.29e-13 Height; CRC cis rs2976388 0.566 rs2585146 chr8:143798641 A/C cg24634471 chr8:143751801 JRK 0.46 6.43 0.33 4.58e-10 Urinary tract infection frequency; CRC cis rs9914988 0.887 rs62066838 chr17:27184533 C/T cg19196414 chr17:27188595 MIR451;MIR144 -0.39 -5.65 -0.3 3.53e-8 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs7615952 0.641 rs2365019 chr3:125808135 T/C cg05084668 chr3:125655381 ALG1L -0.46 -6.58 -0.34 1.91e-10 Blood pressure (smoking interaction); CRC cis rs7312774 0.748 rs1861745 chr12:107301642 C/T cg16260113 chr12:107380972 MTERFD3 0.82 8.06 0.41 1.43e-14 Severe influenza A (H1N1) infection; CRC cis rs1559088 0.895 rs1974784 chr19:33551563 T/G cg27124370 chr19:33622961 WDR88 0.41 5.72 0.3 2.45e-8 Bone ultrasound measurement (broadband ultrasound attenuation); CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg05329982 chr11:62359210 TUT1 0.56 7.41 0.38 1.05e-12 Thyroid stimulating hormone; CRC cis rs720844 0.684 rs16828967 chr2:149332672 G/A cg09247360 chr2:149335327 NA -0.56 -6.04 -0.32 4.27e-9 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs931127 0.505 rs2306362 chr11:65405510 G/T cg27068330 chr11:65405492 SIPA1 -0.8 -12.1 -0.56 3.82e-28 Systemic lupus erythematosus; CRC cis rs2032447 0.898 rs807205 chr6:26075035 C/G cg12310025 chr6:25882481 NA -0.48 -6.76 -0.35 6.39e-11 Intelligence (multi-trait analysis); CRC cis rs2836974 0.666 rs11910705 chr21:40685604 C/T cg22974920 chr21:40686053 BRWD1 -0.45 -6.12 -0.32 2.61e-9 Cognitive function; CRC cis rs589448 0.902 rs2603089 chr12:69776800 C/T cg22834771 chr12:69754056 YEATS4 0.55 8.66 0.43 2.12e-16 Cerebrospinal fluid biomarker levels; CRC trans rs11098499 0.865 rs4001305 chr4:120359236 G/T cg25214090 chr10:38739885 LOC399744 0.66 10.52 0.5 1.65e-22 Corneal astigmatism; CRC cis rs344364 0.511 rs2917515 chr16:1945271 G/C cg03013636 chr16:1946785 NA 0.58 6.66 0.34 1.15e-10 Glomerular filtration rate in chronic kidney disease; CRC cis rs734999 0.588 rs745368 chr1:2524205 C/T cg20673091 chr1:2541236 MMEL1 0.37 6.03 0.32 4.48e-9 Ulcerative colitis; CRC trans rs12599106 0.624 rs2173885 chr16:34992749 G/A cg03395511 chr6:291903 DUSP22 -0.64 -8.89 -0.44 4.19e-17 Menopause (age at onset); CRC cis rs10486722 0.607 rs11771454 chr7:41772806 A/G cg22138096 chr7:41772439 LOC285954 -0.69 -8.23 -0.41 4.53e-15 Pit-and-Fissure caries; CRC cis rs9325144 0.560 rs11182930 chr12:38633693 A/T cg26384229 chr12:38710491 ALG10B -0.56 -8.28 -0.42 3.07e-15 Morning vs. evening chronotype; CRC trans rs783540 0.681 rs1259178 chr15:83271876 T/C cg18393722 chr15:85113863 UBE2QP1 -0.39 -6.13 -0.32 2.45e-9 Schizophrenia; CRC cis rs1153858 1.000 rs10519021 chr15:45631795 G/A cg21132104 chr15:45694354 SPATA5L1 0.57 8.38 0.42 1.52e-15 Homoarginine levels; CRC cis rs8017423 0.630 rs12589687 chr14:90819570 C/G cg14092571 chr14:90743983 NA 0.39 6.03 0.32 4.43e-9 Mortality in heart failure; CRC cis rs7666738 0.830 rs10012003 chr4:99064881 A/G cg17366294 chr4:99064904 C4orf37 0.44 7.47 0.38 7.31e-13 Colonoscopy-negative controls vs population controls; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg10235275 chr10:65225544 JMJD1C;LOC84989 0.38 6.36 0.33 6.92e-10 Liver disease severity in Alagille syndrome; CRC cis rs11792861 0.926 rs7856626 chr9:111775502 C/G cg05043794 chr9:111880884 C9orf5 -0.36 -6.45 -0.34 3.97e-10 Menarche (age at onset); CRC cis rs2976388 0.566 rs2585146 chr8:143798641 A/C cg15511327 chr8:143859410 LYNX1 0.46 7.61 0.39 2.95e-13 Urinary tract infection frequency; CRC cis rs1129187 0.755 rs9471982 chr6:42935998 G/A cg27588902 chr6:42928151 GNMT -0.41 -7.51 -0.38 5.78e-13 Alzheimer's disease in APOE e4+ carriers; CRC trans rs995000 0.931 rs11208000 chr1:63108374 A/G cg05392265 chr1:68516453 DIRAS3 0.43 5.97 0.31 6.04e-9 Triglyceride levels; CRC cis rs2836974 0.897 rs2836925 chr21:40532353 T/C cg11890956 chr21:40555474 PSMG1 1.08 19.11 0.73 2.82e-55 Cognitive function; CRC cis rs7178572 0.568 rs11072643 chr15:77415508 T/A cg22256960 chr15:77711686 NA 0.62 8.06 0.41 1.44e-14 Type 2 diabetes; CRC cis rs7197653 0.748 rs61460037 chr16:68336125 A/C cg05110241 chr16:68378359 PRMT7 -0.73 -7.29 -0.37 2.31e-12 Magnesium levels; CRC cis rs34779708 0.931 rs7079498 chr10:35375344 C/T cg03585969 chr10:35415529 CREM 0.6 8.05 0.41 1.56e-14 Inflammatory bowel disease;Crohn's disease; CRC trans rs10504229 0.953 rs57669205 chr8:58172253 T/C cg04077850 chr5:125800366 GRAMD3 0.38 6.31 0.33 8.92e-10 Developmental language disorder (linguistic errors); CRC cis rs2573652 0.674 rs11630619 chr15:100543367 G/A cg00587665 chr15:100533223 ADAMTS17 -0.39 -6.83 -0.35 4.22e-11 Height; CRC cis rs6762 0.748 rs7936838 chr11:839093 G/C cg11173246 chr11:841376 TSPAN4;POLR2L -0.34 -5.71 -0.3 2.51e-8 Mean platelet volume; CRC cis rs847649 0.618 rs6465880 chr7:102515237 T/C cg18108683 chr7:102477205 FBXL13 -0.64 -11.03 -0.52 2.87e-24 Morning vs. evening chronotype; CRC cis rs6502050 0.835 rs12600852 chr17:80104593 G/A cg02741985 chr17:80059408 CCDC57 0.43 7.15 0.37 5.66e-12 Life satisfaction; CRC cis rs1223397 0.938 rs20499 chr6:13295004 C/T cg20827128 chr6:13274284 PHACTR1 0.46 5.61 0.3 4.29e-8 Blood pressure; CRC cis rs7725052 0.609 rs62357421 chr5:40460495 T/C cg09067459 chr5:40385259 NA -0.4 -6.68 -0.35 9.91e-11 Pediatric autoimmune diseases; CRC cis rs2832191 0.967 rs3787660 chr21:30520907 C/T cg08807101 chr21:30365312 RNF160 0.58 9.57 0.47 2.56e-19 Dental caries; CRC cis rs11690935 0.959 rs10166005 chr2:172607294 C/T cg13550731 chr2:172543902 DYNC1I2 -1.06 -17.36 -0.69 2.17e-48 Schizophrenia; CRC trans rs35110281 0.807 rs6518301 chr21:45016818 T/C cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.42 6.77 0.35 6.06e-11 Mean corpuscular volume; CRC cis rs7408868 0.706 rs7257550 chr19:15292088 C/G cg14696996 chr19:15285081 NOTCH3 0.73 7.77 0.39 1.01e-13 Pulse pressure; CRC cis rs7666738 0.830 rs11097582 chr4:98772201 G/A cg05340658 chr4:99064831 C4orf37 0.55 8.16 0.41 7.26e-15 Colonoscopy-negative controls vs population controls; CRC cis rs17253792 0.822 rs78395034 chr14:56069783 G/A cg24579896 chr14:56047964 C14orf33;KTN1 0.71 5.69 0.3 2.81e-8 Putamen volume; CRC cis rs13191362 1.000 rs13191362 chr6:163033350 A/G cg06582575 chr6:163149167 PACRG;PARK2 0.91 11.8 0.55 4.73e-27 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs728616 0.681 rs3862518 chr10:81917957 A/G cg05935833 chr10:81318306 SFTPA2 -0.46 -5.65 -0.3 3.57e-8 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs155076 1.000 rs261369 chr13:21868420 C/A cg21970626 chr13:21893289 NA 0.42 5.72 0.3 2.36e-8 White matter hyperintensity burden; CRC cis rs2952156 0.920 rs2517958 chr17:37838751 G/A cg07936489 chr17:37558343 FBXL20 -0.46 -6.54 -0.34 2.36e-10 Asthma; CRC cis rs9814567 1.000 rs9289476 chr3:134237103 C/T cg06109529 chr3:134205091 CEP63;ANAPC13 -0.81 -12.02 -0.55 8.05e-28 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs524023 1.000 rs559946 chr11:64358605 T/C cg14139581 chr11:64358342 SLC22A12 0.38 6.04 0.32 4.13e-9 Urate levels in obese individuals; CRC cis rs75920871 0.528 rs11216241 chr11:116899249 A/C cg20608306 chr11:116969690 SIK3 -0.32 -6.12 -0.32 2.69e-9 Subjective well-being; CRC cis rs7617480 0.648 rs9882443 chr3:48749064 G/A cg07636037 chr3:49044803 WDR6 0.78 9.47 0.46 5.6e-19 Subjective well-being (multi-trait analysis);Menarche (age at onset); CRC cis rs7552404 1.000 rs2133134 chr1:76179587 G/A cg10523679 chr1:76189770 ACADM 0.83 11.33 0.53 2.31e-25 Blood metabolite levels;Acylcarnitine levels; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg20529344 chr13:50707427 NA 0.21 6.55 0.34 2.21e-10 Liver disease severity in Alagille syndrome; CRC cis rs28386778 0.863 rs2727288 chr17:61901197 T/A cg07362569 chr17:61921086 SMARCD2 0.38 5.95 0.31 6.87e-9 Prudent dietary pattern; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg18204762 chr7:98741983 SMURF1 0.39 6.06 0.32 3.78e-9 Intelligence (multi-trait analysis); CRC cis rs8072100 0.967 rs8078880 chr17:45676526 G/C cg08085267 chr17:45401833 C17orf57 0.62 9.71 0.47 9.24e-20 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs6952808 0.692 rs56727870 chr7:2029940 T/C cg22963979 chr7:1858916 MAD1L1 -0.53 -7.7 -0.39 1.66e-13 Bipolar disorder and schizophrenia; CRC cis rs34375054 0.526 rs883315 chr12:125676889 T/C cg25124228 chr12:125621409 AACS -0.57 -8.11 -0.41 1.03e-14 Post bronchodilator FEV1/FVC ratio; CRC cis rs2243480 1.000 rs2707844 chr7:66059509 G/A cg18252515 chr7:66147081 NA -1.27 -15.22 -0.64 5.52e-40 Diabetic kidney disease; CRC cis rs8141529 0.748 rs132529 chr22:29296652 A/G cg02153584 chr22:29168773 CCDC117 -0.46 -6.62 -0.34 1.45e-10 Lymphocyte counts; CRC cis rs11677416 1.000 rs1878321 chr2:113544434 A/G cg06156847 chr2:113672199 IL1F7 -0.4 -6.0 -0.31 5.18e-9 Response to antipsychotic treatment in schizophrenia (working memory); CRC cis rs17539620 0.519 rs4077066 chr6:154838448 C/G cg20019720 chr6:154832845 CNKSR3 0.54 10.63 0.51 7.09e-23 Lipoprotein (a) levels; CRC trans rs2797160 1.000 rs1739357 chr6:126019655 T/G cg05039488 chr6:79577232 IRAK1BP1 0.52 7.61 0.39 2.87e-13 Endometrial cancer; CRC cis rs4713118 0.869 rs9468214 chr6:27713299 G/C cg25164649 chr6:28176230 NA 0.6 8.46 0.42 8.81e-16 Parkinson's disease; CRC trans rs11026407 0.967 rs7127246 chr11:22060228 C/G cg00413099 chr20:30192013 ID1 -0.57 -6.38 -0.33 5.92e-10 Plasma thyroid-stimulating hormone levels; CRC cis rs6938 0.618 rs11633472 chr15:75184084 T/G cg14664628 chr15:75095509 CSK -0.6 -9.23 -0.45 3.3e-18 Breast cancer; CRC cis rs10504229 0.728 rs78765835 chr8:58154337 A/G cg02725872 chr8:58115012 NA -0.57 -9.07 -0.45 1.09e-17 Developmental language disorder (linguistic errors); CRC cis rs2239547 0.563 rs4687560 chr3:52898121 T/G cg10802521 chr3:52805072 NEK4 -0.46 -6.2 -0.32 1.65e-9 Schizophrenia; CRC cis rs7584330 0.628 rs73098849 chr2:238389739 G/A cg16989719 chr2:238392110 NA -0.38 -5.64 -0.3 3.6e-8 Prostate cancer; CRC cis rs514406 0.861 rs4926932 chr1:53247495 C/T cg27535305 chr1:53392650 SCP2 0.39 7.07 0.36 9.43e-12 Monocyte count; CRC cis rs6988636 1.000 rs28624331 chr8:124190768 G/A cg27053337 chr8:124217698 FAM83A 0.43 6.59 0.34 1.74e-10 Urinary uromodulin levels; CRC cis rs13064411 0.696 rs6783965 chr3:113198722 C/T cg10517650 chr3:113235015 CCDC52 -0.38 -6.82 -0.35 4.35e-11 Response to simvastatin treatment (PCSK9 protein level change); CRC cis rs2739330 0.731 rs5751792 chr22:24401542 G/A cg09033563 chr22:24373618 LOC391322 -0.49 -7.24 -0.37 3.11e-12 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs2386661 0.547 rs57893347 chr10:5646191 G/A cg26603656 chr10:5671107 NA 0.44 7.53 0.38 4.88e-13 Breast cancer; CRC trans rs7647973 0.626 rs62260720 chr3:49853796 T/A cg21659725 chr3:3221576 CRBN 0.66 7.32 0.37 1.94e-12 Menarche (age at onset); CRC cis rs1451375 1.000 rs921451 chr7:50623285 A/G cg14593290 chr7:50529359 DDC 0.54 7.55 0.38 4.4e-13 Malaria; CRC cis rs6502050 0.835 rs12945993 chr17:80129485 T/C cg02741985 chr17:80059408 CCDC57 0.44 7.29 0.37 2.34e-12 Life satisfaction; CRC cis rs992157 0.804 rs7559525 chr2:219150307 A/G cg13835894 chr2:219148914 PNKD;TMBIM1 -0.35 -6.71 -0.35 8.58e-11 Colorectal cancer; CRC cis rs9311474 0.629 rs13081028 chr3:52555316 G/A cg18099408 chr3:52552593 STAB1 -0.63 -11.97 -0.55 1.14e-27 Electroencephalogram traits; CRC cis rs12612619 0.732 rs3806520 chr2:27276202 G/A cg00617064 chr2:27272375 NA -0.39 -6.47 -0.34 3.49e-10 Venous thromboembolism adjusted for sickle cell variant rs77121243-T; CRC cis rs8060686 0.844 rs7196076 chr16:67887494 T/A cg27539214 chr16:67997921 SLC12A4 -0.46 -5.82 -0.31 1.39e-8 HDL cholesterol;Metabolic syndrome; CRC cis rs6665290 0.935 rs6659424 chr1:227197875 A/G cg10327440 chr1:227177885 CDC42BPA -1.04 -23.45 -0.79 3.61e-72 Myeloid white cell count; CRC cis rs6088813 1.000 rs6142358 chr20:33960308 A/G cg14752227 chr20:34000481 UQCC 0.37 5.79 0.3 1.64e-8 Height; CRC cis rs3740540 0.530 rs2362506 chr10:126290751 C/G cg04949429 chr10:126290192 LHPP 0.43 6.36 0.33 6.77e-10 Obesity-related traits;Acute lymphoblastic leukemia (childhood); CRC cis rs908922 0.676 rs1001834 chr1:152495940 C/A cg09873164 chr1:152488093 CRCT1 0.37 6.22 0.32 1.49e-9 Hair morphology; CRC cis rs853679 1.000 rs735765 chr6:28170297 G/A cg06470822 chr6:28175283 NA 0.83 8.02 0.4 1.86e-14 Depression; CRC cis rs561341 1.000 rs111454793 chr17:30319267 T/C cg00745463 chr17:30367425 LRRC37B -0.88 -9.71 -0.47 9.33e-20 Hip circumference adjusted for BMI; CRC cis rs6570726 0.935 rs399169 chr6:145836353 C/A cg05347473 chr6:146136440 FBXO30 0.37 6.0 0.31 5.27e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs912057 0.833 rs1024245 chr6:6743319 A/G cg06612196 chr6:6737390 NA 0.51 8.17 0.41 6.92e-15 Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction); CRC cis rs10512697 0.536 rs62336073 chr5:3505717 T/C cg19473799 chr5:3511975 NA -0.82 -6.32 -0.33 8.41e-10 Immune response to smallpox vaccine (IL-6); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg13464717 chr19:2269532 OAZ1 0.38 6.18 0.32 1.93e-9 Liver disease severity in Alagille syndrome; CRC cis rs2721195 0.719 rs4925811 chr8:145802447 G/T cg26752003 chr8:145688521 CYHR1 0.51 8.18 0.41 6.05e-15 Age at first birth; CRC cis rs1003719 1.000 rs2835607 chr21:38491973 T/G cg10648535 chr21:38446584 PIGP;TTC3 0.52 7.09 0.36 8.5e-12 Eye color traits; CRC cis rs4666002 0.871 rs10208529 chr2:27786188 A/T cg27432699 chr2:27873401 GPN1 0.46 5.91 0.31 8.62e-9 Phospholipid levels (plasma); CRC cis rs6534441 0.727 rs17768496 chr4:125419243 A/G cg21609808 chr4:125404261 NA 0.44 6.29 0.33 1e-9 Major depressive disorder; CRC cis rs10504229 0.775 rs17804840 chr8:58157045 C/T cg20607798 chr8:58055168 NA 0.46 5.69 0.3 2.79e-8 Developmental language disorder (linguistic errors); CRC cis rs614226 0.935 rs3887875 chr12:120895749 A/G cg27489772 chr12:121021490 NA -0.49 -6.77 -0.35 6.01e-11 Type 1 diabetes nephropathy; CRC cis rs7197653 0.667 rs7190070 chr16:68353983 C/T cg09835421 chr16:68378352 PRMT7 -0.73 -7.6 -0.39 3.1e-13 Magnesium levels; CRC cis rs2204008 0.840 rs3892363 chr12:38479487 G/A cg26384229 chr12:38710491 ALG10B 0.72 10.11 0.49 4.19e-21 Bladder cancer; CRC trans rs7615952 0.673 rs7632557 chr3:125634881 G/C cg07211511 chr3:129823064 LOC729375 -1.2 -18.39 -0.71 1.85e-52 Blood pressure (smoking interaction); CRC cis rs6502050 0.805 rs62078303 chr17:80085210 A/G cg11859384 chr17:80120422 CCDC57 0.37 5.82 0.31 1.36e-8 Life satisfaction; CRC trans rs9908158 1 rs9908158 chr17:33890083 T/C cg19694781 chr19:47549865 TMEM160 0.42 6.46 0.34 3.83e-10 Platelet count;Platelet distribution width; CRC cis rs951366 0.903 rs708723 chr1:205739266 C/T cg14893161 chr1:205819251 PM20D1 0.46 6.9 0.36 2.68e-11 Menarche (age at onset); CRC cis rs4713118 0.616 rs9348789 chr6:28025486 C/T cg06470822 chr6:28175283 NA 0.95 13.58 0.6 1.14e-33 Parkinson's disease; CRC cis rs1218582 0.772 rs6669791 chr1:154845484 G/T cg09359103 chr1:154839909 KCNN3 -0.78 -14.57 -0.63 1.89e-37 Prostate cancer; CRC cis rs10832963 1.000 rs7943121 chr11:18656062 G/C cg20219074 chr11:18656078 SPTY2D1 0.6 8.48 0.42 7.85e-16 Breast cancer; CRC cis rs6700896 0.966 rs1938485 chr1:66082084 A/G cg04111102 chr1:66153794 NA 0.35 6.21 0.32 1.56e-9 C-reactive protein;Mean corpuscular volume;Mean corpuscular hemoglobin; CRC cis rs6740322 0.793 rs9808360 chr2:43546835 C/G cg06169590 chr2:43455088 ZFP36L2;LOC100129726 -0.6 -7.22 -0.37 3.65e-12 Coronary artery disease; CRC cis rs4713118 0.699 rs200978 chr6:27853168 C/G cg20933634 chr6:27740509 NA 0.54 6.98 0.36 1.66e-11 Parkinson's disease; CRC cis rs9649213 0.593 rs35941058 chr7:97918159 T/C cg00277769 chr7:97922759 BAIAP2L1 -0.61 -10.79 -0.51 1.87e-23 Prostate cancer (SNP x SNP interaction); CRC trans rs877282 0.685 rs56234340 chr10:781339 A/G cg22713356 chr15:30763199 NA 1.11 14.14 0.61 8.44e-36 Uric acid levels; CRC cis rs7591163 1.000 rs6738964 chr2:228739135 G/T cg20647610 chr2:228736258 WDR69 -0.51 -7.01 -0.36 1.37e-11 Blood pressure; CRC cis rs7662987 0.517 rs1311615 chr4:100012261 G/A cg13256891 chr4:100009986 ADH5 0.62 8.23 0.41 4.51e-15 Smoking initiation; CRC cis rs2019137 0.936 rs902696 chr2:113954879 G/T cg11763394 chr2:113992921 PAX8;LOC440839;LOC654433 0.49 6.95 0.36 1.94e-11 Lymphocyte counts; CRC cis rs17270561 0.636 rs6923839 chr6:25745853 G/A cg17691542 chr6:26056736 HIST1H1C 0.69 8.63 0.43 2.57e-16 Iron status biomarkers; CRC cis rs9875589 0.509 rs1601868 chr3:14065450 T/C cg14375111 chr3:14165186 TMEM43;CHCHD4 0.41 6.13 0.32 2.46e-9 Ovarian reserve; CRC cis rs3540 0.960 rs8025842 chr15:90995471 C/T cg22089800 chr15:90895588 ZNF774 0.51 7.97 0.4 2.56e-14 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; CRC trans rs116095464 0.558 rs6872854 chr5:209038 G/T cg00938859 chr5:1591904 SDHAP3 0.64 7.16 0.37 5.19e-12 Breast cancer; CRC cis rs2976388 0.507 rs2572874 chr8:143837219 C/T cg12516270 chr8:143859308 LYNX1 0.54 9.66 0.47 1.3e-19 Urinary tract infection frequency; CRC trans rs9951602 0.512 rs61021837 chr18:76648210 A/C cg02800362 chr5:177631904 HNRNPAB 0.72 10.34 0.5 6.97e-22 Obesity-related traits; CRC cis rs1218582 0.772 rs2102423 chr1:154916068 A/G cg24250549 chr1:154909240 PMVK 0.64 10.85 0.51 1.15e-23 Prostate cancer; CRC cis rs3806843 1.000 rs1476768 chr5:140173597 G/A cg16607685 chr5:140181889 PCDHA2;PCDHA1;PCDHA3 -0.26 -5.97 -0.31 6.06e-9 Depressive symptoms (multi-trait analysis); CRC cis rs10078 0.515 rs1053299 chr5:470760 G/A cg08916839 chr5:415575 AHRR 0.81 8.15 0.41 7.71e-15 Fat distribution (HIV); CRC cis rs10744422 1.000 rs2292134 chr12:123334033 C/G cg25930673 chr12:123319894 HIP1R -0.6 -6.32 -0.33 8.36e-10 Schizophrenia; CRC cis rs1183201 0.505 rs1165201 chr6:25874823 A/C cg15691649 chr6:25882328 NA -0.47 -6.3 -0.33 9.33e-10 Uric acid levels; CRC cis rs1552244 0.882 rs3732966 chr3:10015740 C/T cg18598329 chr3:10140678 FANCD2;C3orf24 -0.81 -10.69 -0.51 4.18e-23 Alzheimer's disease; CRC cis rs2806561 0.734 rs1952527 chr1:23400969 T/C cg12483005 chr1:23474871 LUZP1 0.52 7.44 0.38 9.08e-13 Height; CRC cis rs6674176 0.628 rs2240447 chr1:44415415 C/T cg15962314 chr1:44399869 ARTN 0.3 5.74 0.3 2.1e-8 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Cognitive ability; CRC cis rs1552244 0.832 rs3732968 chr3:10013273 A/G cg08888203 chr3:10149979 C3orf24 0.65 8.66 0.43 2.14e-16 Alzheimer's disease; CRC trans rs17685 0.725 rs6947068 chr7:75662056 T/C cg19862616 chr7:65841803 NCRNA00174 -0.97 -18.11 -0.71 2.34e-51 Coffee consumption;Coffee consumption (cups per day); CRC trans rs561341 1.000 rs2470243 chr17:30290955 C/T cg27661571 chr11:113659931 NA -0.96 -11.24 -0.53 5.07e-25 Hip circumference adjusted for BMI; CRC cis rs9322193 0.923 rs11155674 chr6:150032247 T/C cg13206674 chr6:150067644 NUP43 0.65 9.76 0.47 6.08e-20 Lung cancer; CRC cis rs10744422 1.000 rs897385 chr12:123341297 A/G cg25930673 chr12:123319894 HIP1R -0.61 -6.4 -0.33 5.25e-10 Schizophrenia; CRC cis rs9325144 0.723 rs11169535 chr12:39183494 C/T cg26384229 chr12:38710491 ALG10B -0.44 -5.83 -0.31 1.33e-8 Morning vs. evening chronotype; CRC cis rs7119 0.651 rs35657172 chr15:77847813 T/C cg27398640 chr15:77910606 LINGO1 -0.41 -6.83 -0.35 4.04e-11 Type 2 diabetes; CRC trans rs11581859 0.950 rs17390447 chr1:99384002 A/T cg12183875 chr3:169587454 LRRC31 -0.28 -6.26 -0.33 1.23e-9 Response to cognitive-behavioural therapy in anxiety disorder; CRC cis rs72615157 0.664 rs6953580 chr7:99825275 A/G cg19337854 chr7:99768885 GPC2 0.44 5.96 0.31 6.63e-9 Lung function (FEV1/FVC); CRC cis rs11212617 1.000 rs186593 chr11:108262439 G/A cg12106634 chr11:108092400 ATM;NPAT 0.43 6.5 0.34 3.04e-10 Response to metformin in type 2 diabetes (glycemic); CRC cis rs947583 0.588 rs12211505 chr6:136074821 T/C cg06563441 chr6:136217110 PDE7B 0.32 5.6 0.3 4.52e-8 Phosphorus levels; CRC trans rs7615952 0.512 rs11929125 chr3:125359443 G/A cg16558177 chr4:4109446 NA -0.62 -8.74 -0.43 1.23e-16 Blood pressure (smoking interaction); CRC cis rs13108904 0.870 rs1960426 chr4:1274365 C/T cg20887711 chr4:1340912 KIAA1530 0.4 5.72 0.3 2.38e-8 Obesity-related traits; CRC cis rs2011503 1.000 rs78883953 chr19:19630002 G/A cg11584989 chr19:19387371 SF4 0.57 6.39 0.33 5.7e-10 Bipolar disorder; CRC cis rs9394438 0.628 rs4714078 chr6:37543852 G/A cg00985040 chr6:37553208 NA -0.39 -6.46 -0.34 3.69e-10 IgG glycosylation; CRC cis rs11711311 1.000 rs9288983 chr3:113488699 A/G cg15478005 chr3:113465772 ATP6V1A;NAA50 0.43 5.91 0.31 8.58e-9 IgG glycosylation; CRC cis rs8018808 1.000 rs12101153 chr14:77863091 A/C cg20045696 chr14:77926864 AHSA1 -0.36 -5.6 -0.3 4.48e-8 Myeloid white cell count; CRC cis rs9648716 0.608 rs1267622 chr7:140528317 A/G cg10747023 chr7:140774559 NA 0.45 6.2 0.32 1.71e-9 Type 2 diabetes; CRC cis rs1707322 1.000 rs6429588 chr1:46454058 T/G cg03146154 chr1:46216737 IPP 0.51 7.14 0.37 5.96e-12 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs17270561 0.609 rs4711101 chr6:25741970 A/G cg16482183 chr6:26056742 HIST1H1C 0.83 10.69 0.51 4.46e-23 Iron status biomarkers; CRC cis rs8177253 0.665 rs9869535 chr3:133451581 G/A cg01448562 chr3:133502909 NA -0.39 -6.23 -0.32 1.41e-9 Iron status biomarkers; CRC cis rs231513 1.000 rs231518 chr17:41961451 C/T cg26893861 chr17:41843967 DUSP3 0.7 6.52 0.34 2.72e-10 Cognitive function; CRC cis rs9487051 0.676 rs6903107 chr6:109597711 A/G cg12927641 chr6:109611667 NA -0.36 -6.44 -0.33 4.15e-10 Reticulocyte fraction of red cells; CRC cis rs13082711 0.911 rs6773733 chr3:27502131 C/A cg02860705 chr3:27208620 NA 0.62 8.64 0.43 2.56e-16 Systolic blood pressure;Diastolic blood pressure;Blood pressure; CRC cis rs4555082 0.874 rs2735828 chr14:105710486 C/A cg10792982 chr14:105748885 BRF1 0.34 5.76 0.3 1.98e-8 Mean platelet volume;Platelet distribution width; CRC cis rs4713118 0.869 rs7776351 chr6:27726731 A/G cg25164649 chr6:28176230 NA -0.58 -8.25 -0.41 3.92e-15 Parkinson's disease; CRC cis rs1865760 0.964 rs9379802 chr6:25933898 T/A cg03264133 chr6:25882463 NA -0.42 -5.77 -0.3 1.79e-8 Height; CRC cis rs11098499 0.691 rs9307471 chr4:120261262 G/A cg09307838 chr4:120376055 NA 0.6 9.53 0.46 3.71e-19 Corneal astigmatism; CRC cis rs4409675 0.576 rs7356 chr1:28218100 T/C cg23691781 chr1:28212827 C1orf38 0.34 7.98 0.4 2.47e-14 Corneal astigmatism; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg20214692 chr10:1095144 IDI1 0.46 6.46 0.34 3.73e-10 Anxiety disorder; CRC cis rs6840360 0.642 rs7657670 chr4:152353375 A/G cg09659197 chr4:152720779 NA 0.34 6.66 0.34 1.14e-10 Intelligence (multi-trait analysis); CRC cis rs6701037 0.512 rs2285216 chr1:175133012 C/T cg00321850 chr1:175162397 KIAA0040 0.43 7.36 0.38 1.47e-12 Alcohol dependence; CRC cis rs10946940 0.965 rs6910838 chr6:27515519 A/C cg06470822 chr6:28175283 NA -0.51 -7.03 -0.36 1.21e-11 Systemic lupus erythematosus; CRC cis rs853679 0.517 rs868987 chr6:28110148 A/G cg02683197 chr6:28174875 NA -0.87 -10.95 -0.52 5.53e-24 Depression; CRC cis rs311392 0.867 rs367108 chr8:55093142 G/A cg06042504 chr8:55087323 NA -0.44 -6.82 -0.35 4.41e-11 Pelvic organ prolapse (moderate/severe); CRC cis rs561341 1.000 rs497479 chr17:30328605 C/T cg19193384 chr17:30244184 NA -0.63 -7.41 -0.38 1.09e-12 Hip circumference adjusted for BMI; CRC cis rs13118159 0.771 rs13117476 chr4:1334721 A/G cg20092199 chr4:1342459 KIAA1530 0.46 8.28 0.42 3.14e-15 Longevity; CRC cis rs9988450 1 rs9988450 chr1:62924448 C/T cg19896129 chr1:63156450 NA 0.41 6.15 0.32 2.24e-9 Triglycerides; CRC cis rs947583 0.588 rs12204523 chr6:136074994 C/A cg06563441 chr6:136217110 PDE7B 0.32 5.65 0.3 3.47e-8 Phosphorus levels; CRC cis rs7107174 1.000 rs2256187 chr11:77919768 G/A cg02023728 chr11:77925099 USP35 0.51 7.11 0.37 7.15e-12 Testicular germ cell tumor; CRC cis rs6790105 1 rs6790105 chr3:49393409 C/T cg20833759 chr3:49053208 WDR6;DALRD3 0.58 8.95 0.44 2.71e-17 Childhood ear infection; CRC cis rs3816788 0.837 rs6557640 chr8:21771731 A/T cg16476235 chr8:21771668 DOK2 0.42 7.15 0.37 5.49e-12 Lung cancer in ever smokers; CRC cis rs2976388 0.609 rs2164308 chr8:143785659 A/G cg05569086 chr8:143859399 LYNX1 -0.39 -6.76 -0.35 6.24e-11 Urinary tract infection frequency; CRC cis rs9916302 0.784 rs4795361 chr17:37573446 G/A cg15445000 chr17:37608096 MED1 0.42 9.26 0.45 2.62e-18 Glomerular filtration rate (creatinine); CRC cis rs7095944 0.614 rs7099316 chr10:126469005 G/A cg08799069 chr10:126477246 METTL10 -0.45 -7.11 -0.37 7.11e-12 Asthma; CRC cis rs2952156 0.883 rs907088 chr17:37833567 G/C cg07936489 chr17:37558343 FBXL20 -0.4 -5.8 -0.3 1.53e-8 Asthma; CRC cis rs4654899 0.802 rs3767247 chr1:21227338 T/C cg02927042 chr1:21476669 EIF4G3 -0.49 -7.75 -0.39 1.19e-13 Superior frontal gyrus grey matter volume; CRC cis rs9910055 0.762 rs1135215 chr17:42253519 T/C cg19774624 chr17:42201019 HDAC5 -0.69 -10.15 -0.49 3e-21 Total body bone mineral density; CRC cis rs7236492 0.688 rs9709477 chr18:77202786 C/A cg15644404 chr18:77186268 NFATC1 -0.57 -5.9 -0.31 9.19e-9 Inflammatory bowel disease;Crohn's disease; CRC cis rs9910055 0.530 rs8072954 chr17:42294722 G/A cg10896456 chr17:42255109 ASB16;C17orf65 0.34 5.91 0.31 8.61e-9 Total body bone mineral density; CRC cis rs6502050 0.871 rs8066137 chr17:80074316 T/C cg09264619 chr17:80180166 NA 0.36 5.92 0.31 8.27e-9 Life satisfaction; CRC cis rs939574 0.656 rs113370390 chr2:220132837 T/C cg00496455 chr2:220118770 TUBA4A;TUBA4B 0.87 7.11 0.37 7.21e-12 Platelet distribution width; CRC trans rs9467711 0.606 rs16891727 chr6:26488860 C/A cg06606381 chr12:133084897 FBRSL1 -0.81 -6.36 -0.33 6.92e-10 Autism spectrum disorder or schizophrenia; CRC cis rs2997447 0.655 rs2275949 chr1:26385150 C/G cg00300879 chr1:26503847 CNKSR1 0.32 6.2 0.32 1.65e-9 QRS complex (12-leadsum); CRC cis rs17270561 0.583 rs6926425 chr6:25785304 T/C cg17691542 chr6:26056736 HIST1H1C 0.56 7.73 0.39 1.33e-13 Iron status biomarkers; CRC cis rs10779751 1.000 rs7524202 chr1:11297762 T/C cg08854313 chr1:11322531 MTOR 0.66 9.35 0.46 1.38e-18 Body mass index; CRC cis rs6694672 1.000 rs10754214 chr1:197059892 A/G cg13682187 chr1:196946512 CFHR5 0.43 7.0 0.36 1.41e-11 Asthma; CRC cis rs13315871 1.000 rs9869276 chr3:58401076 G/A cg20936604 chr3:58311152 NA -0.75 -7.12 -0.37 6.99e-12 Cholesterol, total; CRC cis rs10463316 0.604 rs28744577 chr5:150768983 A/T cg03212797 chr5:150827313 SLC36A1 -0.49 -7.87 -0.4 5.22e-14 Metabolite levels (Pyroglutamine); CRC cis rs75804782 0.810 rs55694368 chr2:239317692 G/T cg18131467 chr2:239335373 ASB1 -0.68 -5.71 -0.3 2.51e-8 Morning vs. evening chronotype;Chronotype; CRC cis rs8072100 0.967 rs4794058 chr17:45597098 C/T cg08085267 chr17:45401833 C17orf57 0.63 10.18 0.49 2.37e-21 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs8258 0.501 rs474490 chr11:117287794 T/G cg15227623 chr11:117232454 CEP164 0.47 5.78 0.3 1.73e-8 Pulse pressure; CRC cis rs17152411 1.000 rs17152448 chr10:126675645 C/G cg07906193 chr10:126599966 NA 0.57 5.65 0.3 3.49e-8 Height; CRC cis rs11785400 1.000 rs4736365 chr8:143742197 A/G cg10596483 chr8:143751796 JRK 0.49 6.94 0.36 2.06e-11 Schizophrenia; CRC cis rs8114671 0.527 rs6060112 chr20:33489276 A/T cg07148914 chr20:33460835 GGT7 0.47 7.37 0.38 1.38e-12 Height; CRC cis rs10504229 0.906 rs67389108 chr8:58193718 G/A cg22535103 chr8:58192502 C8orf71 -0.74 -11.3 -0.53 2.95e-25 Developmental language disorder (linguistic errors); CRC cis rs6502050 0.764 rs35416122 chr17:80119006 A/G cg11859384 chr17:80120422 CCDC57 -0.36 -5.75 -0.3 2.06e-8 Life satisfaction; CRC trans rs629535 0.773 rs568159 chr8:70032908 C/G cg21567404 chr3:27674614 NA 0.95 16.08 0.66 2.35e-43 Dupuytren's disease; CRC cis rs12410462 0.591 rs11802190 chr1:227635162 A/C cg23173402 chr1:227635558 NA 0.44 5.9 0.31 9.09e-9 Major depressive disorder; CRC cis rs3820068 0.554 rs60233444 chr1:15921330 A/C cg13390004 chr1:15929781 NA 0.49 6.86 0.35 3.37e-11 Systolic blood pressure; CRC cis rs780096 0.526 rs780102 chr2:27659491 T/C cg24768116 chr2:27665128 KRTCAP3 -0.36 -8.22 -0.41 4.71e-15 Total body bone mineral density; CRC cis rs801193 0.569 rs7782587 chr7:66166472 C/T cg18252515 chr7:66147081 NA -0.42 -5.97 -0.31 6.21e-9 Aortic root size; CRC cis rs11622475 1.000 rs7143682 chr14:104413455 C/T cg20488157 chr14:104394430 TDRD9 0.68 9.9 0.48 2.07e-20 Bipolar disorder; CRC trans rs1814175 0.935 rs11040438 chr11:49622521 G/A cg11707556 chr5:10655725 ANKRD33B -0.43 -8.08 -0.41 1.29e-14 Height; CRC cis rs17376456 0.877 rs10073039 chr5:93467709 A/G cg25358565 chr5:93447407 FAM172A 1.02 10.5 0.5 1.92e-22 Diabetic retinopathy; CRC cis rs4713118 0.869 rs9348775 chr6:27695329 C/T cg15786705 chr6:28176104 NA 0.53 7.35 0.38 1.6e-12 Parkinson's disease; CRC cis rs6952808 0.792 rs13224989 chr7:1953766 C/G cg22963979 chr7:1858916 MAD1L1 -0.51 -7.62 -0.39 2.79e-13 Bipolar disorder and schizophrenia; CRC cis rs4423214 0.840 rs4435028 chr11:71183690 C/A cg05163923 chr11:71159392 DHCR7 -0.63 -7.61 -0.39 2.92e-13 Vitamin D levels; CRC cis rs6973256 0.897 rs9656423 chr7:133324987 C/T cg10665199 chr7:133106180 EXOC4 0.38 5.87 0.31 1.06e-8 Intelligence (multi-trait analysis); CRC cis rs780096 0.565 rs813592 chr2:27721971 T/C cg21248554 chr2:27665150 KRTCAP3 -0.3 -7.12 -0.37 7.02e-12 Total body bone mineral density; CRC trans rs596169 0.764 rs73103335 chr1:219111028 A/C cg09853702 chr12:47665230 NA 0.77 6.4 0.33 5.4e-10 Intraocular pressure; CRC cis rs10464366 0.746 rs17171537 chr7:39145647 C/T cg15212455 chr7:39170539 POU6F2 0.44 5.83 0.31 1.31e-8 IgG glycosylation; CRC cis rs36229146 1 rs36229146 chr7:22784486 TTATATATAAATATATATATATATATA/T cg05472934 chr7:22766657 IL6 0.76 12.02 0.55 7.58e-28 Eosinophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Sum eosinophil basophil counts;Eosinophil percentage of white cells; CRC cis rs9916302 0.904 rs9944411 chr17:37483599 T/C cg15445000 chr17:37608096 MED1 -0.41 -9.01 -0.44 1.75e-17 Glomerular filtration rate (creatinine); CRC cis rs9322193 0.923 rs10782317 chr6:150075047 C/T cg00933542 chr6:150070202 PCMT1 -0.34 -7.08 -0.36 8.95e-12 Lung cancer; CRC cis rs1153858 1.000 rs11070453 chr15:45645154 C/G cg10760299 chr15:45669010 GATM 0.5 7.87 0.4 5.11e-14 Homoarginine levels; CRC cis rs9914988 0.943 rs59461345 chr17:27151852 G/T cg16670446 chr17:27188758 MIR451;MIR144 0.53 8.4 0.42 1.32e-15 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs4727027 0.645 rs12704072 chr7:148904888 G/A cg23583168 chr7:148888333 NA -0.92 -17.38 -0.69 1.94e-48 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC cis rs801193 1.000 rs2707836 chr7:66160435 A/C cg11764359 chr7:65958608 NA 0.55 8.52 0.43 5.79e-16 Aortic root size; CRC cis rs9916302 0.904 rs8081338 chr17:37406139 C/T cg15445000 chr17:37608096 MED1 0.42 9.02 0.45 1.59e-17 Glomerular filtration rate (creatinine); CRC cis rs7659604 0.605 rs2071486 chr4:122740162 C/T cg06713675 chr4:122721982 EXOSC9 -0.42 -6.76 -0.35 6.14e-11 Type 2 diabetes; CRC trans rs208520 0.802 rs851600 chr6:66893754 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.91 -12.33 -0.56 5.79e-29 Exhaled nitric oxide output; CRC trans rs7726839 0.540 rs61731455 chr5:665295 A/G cg25482853 chr8:67687455 SGK3 1.16 13.2 0.59 3.15e-32 Obesity-related traits; CRC cis rs2806561 0.929 rs9426694 chr1:23539742 T/C cg19743168 chr1:23544995 NA 0.38 5.98 0.31 5.79e-9 Height; CRC cis rs738322 0.935 rs4384 chr22:38572440 G/C cg25457927 chr22:38595422 NA -0.4 -8.48 -0.42 7.78e-16 Cutaneous nevi; CRC cis rs1059312 0.778 rs4760594 chr12:129296865 T/A cg21616243 chr12:129299702 MGC16384;SLC15A4 -0.74 -13.01 -0.58 1.68e-31 Systemic lupus erythematosus; CRC cis rs2281845 0.507 rs11589642 chr1:201100748 A/G cg24849736 chr1:201084428 NA -0.45 -6.02 -0.32 4.54e-9 Permanent tooth development; CRC cis rs4664304 0.900 rs62176692 chr2:160743463 C/T cg03641300 chr2:160917029 PLA2R1 -0.41 -5.64 -0.3 3.68e-8 Crohn's disease;Inflammatory bowel disease; CRC cis rs9649213 0.593 rs13246843 chr7:98002661 G/T cg00277769 chr7:97922759 BAIAP2L1 -0.6 -10.53 -0.5 1.59e-22 Prostate cancer (SNP x SNP interaction); CRC cis rs2952156 0.920 rs1476278 chr17:37836243 C/T cg00129232 chr17:37814104 STARD3 -0.71 -12.58 -0.57 6.95e-30 Asthma; CRC cis rs13108904 0.935 rs4246685 chr4:1279727 T/C cg02018176 chr4:1364513 KIAA1530 0.48 7.94 0.4 3.22e-14 Obesity-related traits; CRC cis rs873946 0.586 rs12251911 chr10:134570595 A/G cg26818010 chr10:134567672 INPP5A -0.65 -8.81 -0.44 7.29e-17 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CRC trans rs10983614 1.000 rs7867776 chr9:120072627 A/G cg03855706 chr16:770778 FAM173A 0.46 6.05 0.32 3.9e-9 Survival in pancreatic cancer; CRC cis rs13118159 0.801 rs7664474 chr4:1329116 T/A cg19318889 chr4:1322082 MAEA 0.52 7.78 0.39 9.7e-14 Longevity; CRC cis rs1865760 0.516 rs9295684 chr6:26069669 T/C cg16482183 chr6:26056742 HIST1H1C 0.51 7.39 0.38 1.24e-12 Height; CRC cis rs6445967 1.000 rs1913716 chr3:58308331 G/A cg23715586 chr3:58305044 RPP14 0.35 5.88 0.31 1e-8 Platelet count; CRC cis rs7259376 1.000 rs1975174 chr19:22515251 G/T cg02657401 chr19:22469223 NA -0.38 -8.72 -0.43 1.44e-16 Menopause (age at onset); CRC cis rs9682041 0.696 rs11709437 chr3:170085568 T/G cg11886554 chr3:170076028 SKIL 0.69 8.15 0.41 7.52e-15 Glomerular filtration rate in non diabetics (creatinine);Glomerular filtration rate (creatinine); CRC cis rs2732480 0.577 rs2634680 chr12:48734564 T/C cg04545296 chr12:48745243 ZNF641 0.36 6.22 0.32 1.49e-9 Hemoglobin concentration;Red blood cell count;Hematocrit; CRC cis rs1957429 0.901 rs60979440 chr14:65390231 A/G cg23373153 chr14:65346875 NA -0.82 -8.53 -0.43 5.26e-16 Pediatric areal bone mineral density (radius); CRC cis rs7552404 0.690 rs2029681 chr1:76333846 G/A cg10523679 chr1:76189770 ACADM -0.67 -8.71 -0.43 1.46e-16 Blood metabolite levels;Acylcarnitine levels; CRC cis rs9926296 0.682 rs645019 chr16:89716883 C/T cg03605463 chr16:89740564 NA 0.55 8.4 0.42 1.4e-15 Vitiligo; CRC cis rs13191362 0.935 rs67368176 chr6:162968436 A/T cg06582575 chr6:163149167 PACRG;PARK2 0.82 10.19 0.49 2.3e-21 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs1046896 0.594 rs8070403 chr17:80865404 A/G cg03160526 chr17:80928410 B3GNTL1 0.57 7.62 0.39 2.66e-13 Glycated hemoglobin levels; CRC cis rs887829 0.641 rs7586110 chr2:234590527 T/G cg07512295 chr2:234599026 UGT1A6;UGT1A10;UGT1A9;UGT1A7;UGT1A8 0.38 5.85 0.31 1.2e-8 Metabolic traits;Bilirubin levels;Cholelithiasis-related traits in sickle cell anemia;Metabolite levels;Total bilirubin levels in HIV-1 infection;Serum metabolite levels;Blood metabolite levels; CRC cis rs2304069 0.779 rs245080 chr5:149354805 A/G cg22760475 chr5:149380129 HMGXB3;TIGD6 -0.54 -6.45 -0.34 3.95e-10 HIV-1 control; CRC cis rs2032447 0.765 rs1935235 chr6:26067782 C/G cg03264133 chr6:25882463 NA -0.48 -6.55 -0.34 2.16e-10 Intelligence (multi-trait analysis); CRC cis rs597539 0.652 rs514296 chr11:68654182 G/T cg06028808 chr11:68637592 NA 0.38 6.16 0.32 2.07e-9 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs365302 1.000 rs375150 chr6:159650025 G/T cg14500486 chr6:159655392 FNDC1 0.44 6.82 0.35 4.31e-11 Coronary heart disease; CRC cis rs7584330 0.617 rs10202195 chr2:238352128 A/G cg16989719 chr2:238392110 NA -0.44 -8.0 -0.4 2.13e-14 Prostate cancer; CRC trans rs11581859 1.000 rs4477298 chr1:99293842 A/G cg12183875 chr3:169587454 LRRC31 0.27 6.27 0.33 1.13e-9 Response to cognitive-behavioural therapy in anxiety disorder; CRC cis rs9372498 0.831 rs62421535 chr6:118724565 C/A cg15382696 chr6:118971807 C6orf204 0.56 5.62 0.3 4.18e-8 Diastolic blood pressure; CRC cis rs7113874 0.589 rs10769910 chr11:8499406 T/C cg20771178 chr11:8615675 STK33 0.34 5.67 0.3 3.07e-8 Body mass index in physically active individuals;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs7618915 0.501 rs1468638 chr3:52748058 T/C cg10802521 chr3:52805072 NEK4 -0.58 -9.05 -0.45 1.31e-17 Bipolar disorder; CRC cis rs8114671 0.562 rs6088642 chr20:33483186 G/T cg07148914 chr20:33460835 GGT7 0.4 6.44 0.33 4.17e-10 Height; CRC cis rs2816062 0.813 rs2745318 chr1:18895844 C/T cg18795169 chr1:18902165 NA 0.89 18.76 0.72 6.5e-54 Urate levels in lean individuals; CRC cis rs4808199 0.947 rs2099333 chr19:19605963 C/T cg03709012 chr19:19516395 GATAD2A 1.0 12.03 0.55 7.11e-28 Nonalcoholic fatty liver disease; CRC cis rs7493 0.755 rs17166861 chr7:95020602 G/C cg20119798 chr7:94954144 PON1 -0.47 -5.88 -0.31 9.89e-9 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs853679 0.517 rs4713150 chr6:28136212 G/A cg23161317 chr6:28129485 ZNF389 0.53 6.38 0.33 5.94e-10 Depression; CRC cis rs7843479 0.582 rs13439690 chr8:21778082 T/C cg08288130 chr8:21771540 DOK2 0.29 5.72 0.3 2.34e-8 Mean corpuscular volume; CRC cis rs28386778 0.897 rs2727333 chr17:61876023 G/A cg22520471 chr17:61851767 DDX42;CCDC47 0.75 11.69 0.54 1.18e-26 Prudent dietary pattern; CRC cis rs28386778 0.704 rs1051688 chr17:62006433 G/C cg23090583 chr17:61904693 PSMC5;FTSJ3 -0.68 -10.26 -0.49 1.32e-21 Prudent dietary pattern; CRC cis rs2032447 0.702 rs199753 chr6:26001888 G/A cg26028573 chr6:26043587 HIST1H2BB 0.52 7.54 0.38 4.64e-13 Intelligence (multi-trait analysis); CRC cis rs3796352 1.000 rs11714876 chr3:53101640 C/G cg06204229 chr3:52865917 ITIH4 -0.5 -5.92 -0.31 8.08e-9 Immune reponse to smallpox (secreted IL-2); CRC cis rs1577917 1.000 rs12196037 chr6:86694631 G/A cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.58 -7.21 -0.37 3.81e-12 Response to antipsychotic treatment; CRC cis rs611744 0.625 rs11991891 chr8:109294858 G/A cg21045802 chr8:109455806 TTC35 0.43 6.53 0.34 2.44e-10 Dupuytren's disease; CRC cis rs12926788 0.546 rs200531 chr16:24756172 G/A cg00339695 chr16:24857497 SLC5A11 -0.44 -9.16 -0.45 5.85e-18 Ejection fraction in Tripanosoma cruzi seropositivity; CRC cis rs282587 0.530 rs428853 chr13:113387222 T/C cg04656015 chr13:113407548 ATP11A 0.65 8.07 0.41 1.33e-14 Glycated hemoglobin levels; CRC trans rs9329221 0.527 rs6989657 chr8:10330873 C/G cg16141378 chr3:129829833 LOC729375 -0.42 -6.22 -0.32 1.47e-9 Neuroticism; CRC cis rs2576037 0.526 rs7240239 chr18:44460037 T/C cg24750912 chr18:44543259 TCEB3CL;KATNAL2 0.29 5.9 0.31 9e-9 Personality dimensions; CRC trans rs3849570 0.695 rs9830445 chr3:81508063 T/G cg23387109 chr10:94051229 MARCH5;CPEB3 -0.44 -6.0 -0.31 5.25e-9 Waist circumference;Body mass index; CRC trans rs7618501 1.000 rs57648519 chr3:49813169 C/A cg21659725 chr3:3221576 CRBN 0.91 17.8 0.7 4.22e-50 Intelligence (multi-trait analysis); CRC cis rs847649 0.842 rs4729873 chr7:102731781 G/A cg18108683 chr7:102477205 FBXL13 0.53 8.36 0.42 1.77e-15 Morning vs. evening chronotype; CRC cis rs2276314 0.802 rs58906216 chr18:33630297 T/C cg19628046 chr18:33552617 C18orf21 0.57 7.63 0.39 2.51e-13 Endometriosis;Drug-induced torsades de pointes; CRC cis rs17345786 0.798 rs4257518 chr3:101281709 C/T cg11279151 chr3:101281821 RG9MTD1 0.69 9.51 0.46 4.05e-19 Colonoscopy-negative controls vs population controls; CRC trans rs10983614 1.000 rs7867776 chr9:120072627 A/G cg25733613 chr11:111637437 PPP2R1B 0.45 6.26 0.33 1.2e-9 Survival in pancreatic cancer; CRC cis rs9393692 0.905 rs7747133 chr6:26293470 C/T cg00631329 chr6:26305371 NA -0.69 -13.6 -0.6 9.99e-34 Educational attainment; CRC cis rs6933660 0.800 rs963193 chr6:151789355 G/T cg14416726 chr6:151773293 C6orf211;RMND1 0.62 9.6 0.47 2.16e-19 Menarche (age at onset); CRC trans rs1005277 0.579 rs2472183 chr10:38392495 T/G cg23533926 chr12:111358616 MYL2 -0.52 -7.84 -0.4 6.17e-14 Extrinsic epigenetic age acceleration; CRC cis rs7605827 0.823 rs11689269 chr2:15621917 C/G cg19274914 chr2:15703543 NA 0.39 6.05 0.32 3.96e-9 Educational attainment (years of education); CRC cis rs7255436 0.965 rs7254882 chr19:8453822 A/G cg10174797 chr19:8464628 RAB11B 0.44 7.63 0.39 2.48e-13 HDL cholesterol; CRC cis rs9462846 0.658 rs9471970 chr6:42913646 G/A cg21280719 chr6:42927975 GNMT -0.32 -6.23 -0.32 1.41e-9 Blood protein levels; CRC cis rs4663866 0.901 rs34040298 chr2:239191607 T/C cg16914508 chr2:239161102 PER2 0.75 8.09 0.41 1.19e-14 Irritable bowel syndrome; CRC cis rs2882667 0.867 rs11749045 chr5:138420960 C/T cg04439458 chr5:138467593 SIL1 -0.31 -5.6 -0.3 4.49e-8 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs1580019 0.961 rs1610143 chr7:32498331 C/T cg07520158 chr7:32535189 LSM5;AVL9 0.45 6.48 0.34 3.4e-10 Cognitive ability; CRC cis rs896854 0.654 rs6982393 chr8:95980708 T/C cg13393036 chr8:95962371 TP53INP1 -0.54 -9.31 -0.46 1.83e-18 Type 2 diabetes; CRC cis rs4862750 0.914 rs11945845 chr4:187874136 T/C cg07414643 chr4:187882934 NA 0.37 6.41 0.33 5.12e-10 Lobe attachment (rater-scored or self-reported); CRC cis rs73200209 0.744 rs3741768 chr12:116446445 C/T cg01776926 chr12:116560359 MED13L -0.63 -7.4 -0.38 1.15e-12 Total body bone mineral density; CRC cis rs3857067 1.000 rs2219755 chr4:95015684 A/G cg11021082 chr4:95130006 SMARCAD1 -0.4 -6.05 -0.32 3.9e-9 QT interval; CRC cis rs1395 0.710 rs2083363 chr2:27475318 G/C cg14242246 chr2:27434262 C2orf28;SLC5A6 0.32 6.21 0.32 1.55e-9 Blood metabolite levels; CRC trans rs9561329 0.800 rs9561335 chr13:94034057 A/T cg23072629 chr2:239195537 PER2 0.32 6.01 0.31 5.03e-9 Neuroticism (age interaction); CRC cis rs9611565 0.659 rs4822037 chr22:41945113 G/T cg17554472 chr22:41940697 POLR3H -0.57 -6.03 -0.32 4.3e-9 Vitiligo; CRC cis rs2075371 1.000 rs432487 chr7:133990114 T/G cg20476274 chr7:133979776 SLC35B4 0.8 14.55 0.63 2.29e-37 Mean platelet volume; CRC trans rs7824557 0.524 rs7835318 chr8:10953874 G/A cg08071915 chr8:12219732 FAM66A 0.34 5.98 0.31 5.67e-9 Retinal vascular caliber; CRC cis rs60843830 1.000 rs60149603 chr2:285421 A/G cg25945732 chr2:264204 ACP1;SH3YL1 0.71 11.24 0.53 5.12e-25 Spherical equivalent (joint analysis main effects and education interaction); CRC cis rs2836950 0.520 rs8133928 chr21:40689963 G/A cg11890956 chr21:40555474 PSMG1 -0.61 -8.99 -0.44 1.95e-17 Menarche (age at onset); CRC trans rs66887589 0.934 rs2389873 chr4:120554714 A/G cg25214090 chr10:38739885 LOC399744 -0.42 -6.62 -0.34 1.5e-10 Diastolic blood pressure; CRC cis rs7412746 0.611 rs4970931 chr1:150910727 G/A cg17724175 chr1:150552817 MCL1 0.4 6.14 0.32 2.37e-9 Melanoma; CRC cis rs796364 1.000 rs281788 chr2:200783705 A/T cg12253985 chr2:200820533 C2orf60;C2orf47 0.6 6.61 0.34 1.52e-10 Schizophrenia; CRC cis rs1348850 0.872 rs4893825 chr2:178298687 A/G cg02961200 chr2:178257176 LOC100130691;AGPS 0.57 8.1 0.41 1.12e-14 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs9372498 0.536 rs9481808 chr6:118784571 G/A cg18833306 chr6:118973337 C6orf204 0.45 5.82 0.31 1.44e-8 Diastolic blood pressure; CRC cis rs12893668 0.572 rs4906356 chr14:104138701 C/T cg08213375 chr14:104286397 PPP1R13B 0.44 6.9 0.36 2.7e-11 Reticulocyte count; CRC cis rs1552244 0.554 rs34391585 chr3:9999208 G/C cg02579736 chr3:10068473 FANCD2;CIDECP 0.65 9.23 0.45 3.51e-18 Alzheimer's disease; CRC cis rs10911232 0.507 rs4442336 chr1:182982538 T/G ch.1.3577855R chr1:183094577 LAMC1 0.87 15.34 0.65 1.91e-40 Hypertriglyceridemia; CRC cis rs7487637 0.566 rs875023 chr12:48194435 A/G cg14736327 chr12:48174669 SLC48A1 0.59 7.45 0.38 8.11e-13 Mononucleosis; CRC cis rs6840360 0.934 rs6817058 chr4:152603865 T/C cg09659197 chr4:152720779 NA 0.51 10.69 0.51 4.4e-23 Intelligence (multi-trait analysis); CRC cis rs7809950 0.954 rs3779494 chr7:107250355 G/A cg23024343 chr7:107201750 COG5 0.63 9.09 0.45 9.66e-18 Coronary artery disease; CRC cis rs875971 0.505 rs2462573 chr7:65507392 C/T cg18912574 chr7:65842487 NCRNA00174 -0.35 -6.03 -0.32 4.52e-9 Aortic root size; CRC trans rs1814175 0.817 rs1996982 chr11:49972619 G/T cg11707556 chr5:10655725 ANKRD33B -0.44 -8.34 -0.42 2.03e-15 Height; CRC trans rs10243593 0.673 rs6966917 chr7:40075461 G/A cg13911576 chr9:84174038 NA 0.34 6.0 0.31 5.32e-9 Lymphocyte counts; CRC cis rs57221529 0.766 rs72706608 chr5:559203 C/T cg16447950 chr5:562315 NA -0.84 -11.5 -0.54 6.14e-26 Lung disease severity in cystic fibrosis; CRC cis rs9914988 0.887 rs2070265 chr17:27075423 A/G cg07195577 chr17:27052828 TLCD1 -0.4 -6.0 -0.31 5.12e-9 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs2625529 0.730 rs2957373 chr15:72340929 T/C cg16672083 chr15:72433130 SENP8 0.43 6.27 0.33 1.15e-9 Red blood cell count; CRC cis rs1552244 1.000 rs17032295 chr3:10086680 C/T cg08888203 chr3:10149979 C3orf24 0.7 10.03 0.48 7.85e-21 Alzheimer's disease; CRC cis rs1552244 1.000 rs35220123 chr3:10083169 C/T cg16606324 chr3:10149918 C3orf24 0.73 9.77 0.47 5.73e-20 Alzheimer's disease; CRC cis rs9292777 0.733 rs348595 chr5:40323714 A/G cg09067459 chr5:40385259 NA -0.56 -9.61 -0.47 1.89e-19 Crohn's disease;Multiple sclerosis; CRC trans rs208520 0.779 rs208446 chr6:66903515 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.9 -11.28 -0.53 3.66e-25 Exhaled nitric oxide output; CRC cis rs7552404 0.924 rs1858536 chr1:76161595 G/T cg03433033 chr1:76189801 ACADM 0.92 14.18 0.62 5.85e-36 Blood metabolite levels;Acylcarnitine levels; CRC cis rs10751667 0.666 rs7395488 chr11:954111 T/C cg06064525 chr11:970664 AP2A2 -0.31 -6.28 -0.33 1.07e-9 Alzheimer's disease (late onset); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg23903483 chr12:54120889 CALCOCO1 0.4 6.03 0.32 4.44e-9 Intelligence (multi-trait analysis); CRC cis rs2032447 0.714 rs2051540 chr6:25947197 T/C cg04800585 chr6:26043546 HIST1H2BB 0.48 6.93 0.36 2.28e-11 Intelligence (multi-trait analysis); CRC cis rs6831352 0.918 rs17817958 chr4:100061245 A/C cg13256891 chr4:100009986 ADH5 0.64 8.27 0.41 3.38e-15 Alcohol dependence; CRC cis rs427941 0.550 rs1902 chr7:101768791 C/T cg06246474 chr7:101738831 CUX1 0.37 5.66 0.3 3.27e-8 Plasma omega-3 polyunsaturated fatty acid level (eicosapentaenoic acid); CRC cis rs10779751 1.000 rs2024627 chr1:11298790 T/C cg08854313 chr1:11322531 MTOR 0.66 9.35 0.46 1.38e-18 Body mass index; CRC cis rs798554 0.680 rs2533889 chr7:2900309 G/C cg19346786 chr7:2764209 NA -0.37 -6.05 -0.32 3.87e-9 Height; CRC trans rs1455244 0.700 rs7229302 chr18:11508904 G/T cg25552655 chr19:33864476 CEBPG 0.39 6.05 0.32 4.03e-9 Schizophrenia; CRC cis rs3820068 0.603 rs67349836 chr1:15966176 T/C cg24675056 chr1:15929824 NA 0.51 7.28 0.37 2.53e-12 Systolic blood pressure; CRC cis rs514406 0.505 rs436363 chr1:53172163 T/C cg08859206 chr1:53392774 SCP2 -0.38 -5.9 -0.31 9.03e-9 Monocyte count; CRC cis rs9399137 0.507 rs13214669 chr6:135299959 T/C cg24558204 chr6:135376177 HBS1L 0.62 9.3 0.46 1.95e-18 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; CRC cis rs9911578 1.000 rs2611782 chr17:56717956 T/C cg05425664 chr17:57184151 TRIM37 -0.5 -7.95 -0.4 3.02e-14 Intelligence (multi-trait analysis); CRC cis rs57221529 0.709 rs4957056 chr5:570105 T/C cg17948913 chr5:572064 NA 0.56 6.51 0.34 2.77e-10 Lung disease severity in cystic fibrosis; CRC cis rs34526934 0.608 rs34720456 chr2:177027292 G/A cg03152288 chr2:177042942 NA -0.57 -7.37 -0.38 1.4e-12 Obstructive sleep apnea trait (apnea hypopnea index); CRC cis rs1448094 0.511 rs61930037 chr12:86154503 G/A cg02569458 chr12:86230093 RASSF9 0.51 8.43 0.42 1.13e-15 Major depressive disorder; CRC cis rs3008870 0.701 rs2815358 chr1:67493778 T/C cg08660285 chr1:67390436 MIER1;WDR78 0.56 7.94 0.4 3.26e-14 Lymphocyte percentage of white cells; CRC cis rs72627123 0.867 rs8020310 chr14:74494437 A/G cg12022184 chr14:74485813 ENTPD5;C14orf45 0.72 6.19 0.32 1.8e-9 Morning vs. evening chronotype; CRC cis rs4481887 0.790 rs4453078 chr1:248411889 A/G cg13385794 chr1:248469461 NA -0.33 -6.27 -0.33 1.15e-9 Common traits (Other); CRC cis rs11190604 1.000 rs11190592 chr10:102291059 T/C cg16342193 chr10:102329863 NA -0.36 -5.91 -0.31 8.64e-9 Palmitoleic acid (16:1n-7) levels; CRC cis rs2811415 0.597 rs1057156 chr3:127800071 A/G cg13719885 chr3:127795394 NA -0.4 -5.87 -0.31 1.05e-8 Lung function (FEV1/FVC); CRC cis rs10197940 0.624 rs13393122 chr2:152413315 A/G cg06191203 chr2:152266755 RIF1 -0.66 -9.43 -0.46 7.85e-19 Lung cancer; CRC cis rs7937682 0.889 rs516263 chr11:111484719 A/C cg19812747 chr11:111475976 SIK2 -0.59 -10.14 -0.49 3.31e-21 Primary sclerosing cholangitis; CRC cis rs10751667 0.643 rs11246362 chr11:969818 C/T cg01483505 chr11:975446 AP2A2 0.46 7.66 0.39 2.11e-13 Alzheimer's disease (late onset); CRC cis rs10256972 0.591 rs11766651 chr7:1161646 A/G cg04025307 chr7:1156635 C7orf50 0.73 11.89 0.55 2.26e-27 Longevity;Endometriosis; CRC cis rs7786877 0.723 rs73407376 chr7:100215200 C/T cg20848291 chr7:100343083 ZAN -0.52 -6.44 -0.33 4.24e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC trans rs561341 0.700 rs79272796 chr17:30226974 T/C cg20587970 chr11:113659929 NA -0.56 -7.6 -0.39 3.1400000000000003e-13 Hip circumference adjusted for BMI; CRC cis rs10504229 0.817 rs78138632 chr8:58191341 G/T cg01721255 chr8:58191610 C8orf71 0.61 5.87 0.31 1.05e-8 Developmental language disorder (linguistic errors); CRC cis rs7493 0.853 rs2299266 chr7:95049073 A/G cg01874867 chr7:94954059 PON1 -0.51 -6.36 -0.33 6.79e-10 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs921968 0.528 rs35695178 chr2:219589164 C/T cg02176678 chr2:219576539 TTLL4 -0.4 -6.39 -0.33 5.73e-10 Mean corpuscular hemoglobin concentration; CRC cis rs7666738 0.830 rs13119913 chr4:98977983 G/T cg17366294 chr4:99064904 C4orf37 0.44 7.32 0.37 1.94e-12 Colonoscopy-negative controls vs population controls; CRC cis rs4731207 0.565 rs998054 chr7:124640487 G/A cg23710748 chr7:124431027 NA -0.39 -6.17 -0.32 1.99e-9 Cutaneous malignant melanoma; CRC cis rs9905704 0.624 rs6503891 chr17:57065924 A/C cg12560992 chr17:57184187 TRIM37 0.64 9.8 0.48 4.73e-20 Testicular germ cell tumor; CRC cis rs13108904 0.539 rs13141992 chr4:1340765 C/T cg20092199 chr4:1342459 KIAA1530 0.46 7.25 0.37 3.06e-12 Obesity-related traits; CRC cis rs7927592 0.956 rs2510384 chr11:68391837 C/A cg16797656 chr11:68205561 LRP5 0.37 5.71 0.3 2.54e-8 Total body bone mineral density; CRC cis rs11792861 0.816 rs744980 chr9:111690388 C/T cg05043794 chr9:111880884 C9orf5 -0.32 -5.74 -0.3 2.16e-8 Menarche (age at onset); CRC trans rs747782 0.585 rs1316604 chr11:48279796 G/A cg15704280 chr7:45808275 SEPT13 0.68 6.58 0.34 1.89e-10 Intraocular pressure; CRC cis rs939584 1.000 rs2867112 chr2:651349 T/G cg03610516 chr2:642275 NA -0.42 -5.89 -0.31 9.71e-9 Body mass index; CRC cis rs6496667 1.000 rs8023776 chr15:90897952 A/G cg04176472 chr15:90893244 GABARAPL3 -0.51 -7.6 -0.39 3.04e-13 Rheumatoid arthritis; CRC cis rs4332037 0.802 rs73048106 chr7:1929019 G/T cg24505167 chr7:1915268 MAD1L1 -0.44 -6.23 -0.32 1.4e-9 Bipolar disorder; CRC cis rs10751667 0.643 rs11246362 chr11:969818 C/T ch.11.42038R chr11:967971 AP2A2 0.58 9.98 0.48 1.16e-20 Alzheimer's disease (late onset); CRC cis rs6933660 0.720 rs6914656 chr6:151753421 C/G cg14262678 chr6:151773367 RMND1;C6orf211 0.54 8.93 0.44 3.08e-17 Menarche (age at onset); CRC cis rs1997103 0.954 rs2177809 chr7:55378125 T/C cg17469321 chr7:55412551 NA 0.74 11.37 0.53 1.7e-25 QRS interval (sulfonylurea treatment interaction); CRC cis rs7811142 0.943 rs11769886 chr7:99998607 G/A cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.73 9.15 0.45 6.1e-18 Platelet count; CRC cis rs7937682 0.640 rs587010 chr11:111425658 C/A cg09085632 chr11:111637200 PPP2R1B -0.73 -12.03 -0.55 7.36e-28 Primary sclerosing cholangitis; CRC cis rs11864453 0.826 rs12708928 chr16:72137227 C/A cg23815491 chr16:72088622 HP 0.52 7.86 0.4 5.71e-14 Fibrinogen levels; CRC cis rs7412746 0.658 rs2275235 chr1:150730279 A/G cg10589385 chr1:150898437 SETDB1 0.31 6.34 0.33 7.79e-10 Melanoma; CRC cis rs6500395 0.926 rs2883643 chr16:48693018 C/G cg04672837 chr16:48644449 N4BP1 0.42 5.97 0.31 5.99e-9 Response to tocilizumab in rheumatoid arthritis; CRC cis rs459571 0.606 rs457420 chr9:136909261 A/G cg13789015 chr9:136890014 NCRNA00094 -0.4 -5.7 -0.3 2.65e-8 Platelet distribution width; CRC cis rs12048904 0.505 rs10493936 chr1:101213335 A/T cg15686842 chr1:101360669 SLC30A7;EXTL2 -0.55 -7.43 -0.38 9.72e-13 Multiple sclerosis; CRC cis rs6540559 1.000 rs6540559 chr1:209982025 G/A cg21951975 chr1:209979733 IRF6 0.43 6.66 0.34 1.14e-10 Cleft lip with or without cleft palate; CRC cis rs7197653 0.586 rs55856208 chr16:68324210 A/T cg09835421 chr16:68378352 PRMT7 -0.73 -7.23 -0.37 3.35e-12 Magnesium levels; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg20910436 chr10:74856386 P4HA1 0.42 6.04 0.32 4.2e-9 Response to antipsychotic treatment; CRC cis rs8180040 0.726 rs4078466 chr3:47126543 C/T cg10298567 chr3:47292165 KIF9 -0.38 -6.22 -0.32 1.51e-9 Colorectal cancer; CRC cis rs10752881 1.000 rs12035773 chr1:182985716 A/G ch.1.3577855R chr1:183094577 LAMC1 0.86 15.22 0.64 5.91e-40 Colorectal cancer; CRC cis rs10484885 0.763 rs56401039 chr6:90522486 C/T cg13799429 chr6:90582589 CASP8AP2 -0.71 -7.59 -0.39 3.23e-13 QRS interval (sulfonylurea treatment interaction); CRC cis rs875971 0.540 rs736270 chr7:65428822 T/C cg00343986 chr7:65444356 GUSB 0.55 8.03 0.4 1.81e-14 Aortic root size; CRC cis rs832540 1.000 rs252913 chr5:56195846 C/T cg24531977 chr5:56204891 C5orf35 0.39 6.04 0.32 4.08e-9 Coronary artery disease; CRC cis rs7493 0.755 rs17166859 chr7:94995519 T/C cg17330251 chr7:94953956 PON1 -0.52 -6.64 -0.34 1.26e-10 Yu-Zhi constitution type in type 2 diabetes; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg08642938 chr17:21117993 TMEM11 0.49 6.45 0.34 3.9e-10 Anxiety disorder; CRC cis rs6681460 0.649 rs1415984 chr1:67002117 A/G cg02459107 chr1:67143332 SGIP1 0.36 5.61 0.3 4.36e-8 Presence of antiphospholipid antibodies; CRC cis rs7918232 0.698 rs6482586 chr10:27297829 A/C cg14240646 chr10:27532245 ACBD5 -0.64 -7.1 -0.36 7.8e-12 Breast cancer; CRC cis rs4731207 0.596 rs10269342 chr7:124693845 C/G cg23710748 chr7:124431027 NA 0.42 6.76 0.35 6.39e-11 Cutaneous malignant melanoma; CRC cis rs4819052 0.851 rs2838836 chr21:46665875 G/T cg02159808 chr21:46707872 POFUT2;LOC642852 0.5 6.61 0.34 1.57e-10 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs7772486 0.790 rs2243665 chr6:146208120 A/C cg23711669 chr6:146136114 FBXO30 0.67 11.66 0.54 1.61e-26 Lobe attachment (rater-scored or self-reported); CRC cis rs17376456 0.569 rs896729 chr5:93222178 A/G cg09848695 chr5:92956644 FAM172A;MIR2277 -0.52 -5.88 -0.31 1.02e-8 Diabetic retinopathy; CRC cis rs798554 1.000 rs798536 chr7:2766383 G/A cg14895029 chr7:2775587 GNA12 -0.45 -6.53 -0.34 2.51e-10 Height; CRC trans rs6550704 0.687 rs9865314 chr3:22634337 A/G cg11530914 chr16:67281528 FHOD1;SLC9A5 -0.4 -6.0 -0.31 5.3e-9 Daytime sleep phenotypes; CRC cis rs7107174 1.000 rs10899492 chr11:78109810 G/A cg02023728 chr11:77925099 USP35 0.4 6.53 0.34 2.44e-10 Testicular germ cell tumor; CRC cis rs3820928 1.000 rs4675120 chr2:227774888 C/T cg11843606 chr2:227700838 RHBDD1 -0.41 -5.98 -0.31 5.91e-9 Pulmonary function; CRC cis rs75804782 0.641 rs72983861 chr2:239326126 G/A cg18131467 chr2:239335373 ASB1 -0.69 -5.95 -0.31 6.99e-9 Morning vs. evening chronotype;Chronotype; CRC trans rs1814175 0.791 rs10769625 chr11:49869887 G/A cg15704280 chr7:45808275 SEPT13 -1.01 -20.25 -0.74 8.67e-60 Height; CRC cis rs1046896 0.514 rs67735447 chr17:80823042 G/T cg02711726 chr17:80685570 FN3KRP -0.5 -6.91 -0.36 2.6e-11 Glycated hemoglobin levels; CRC cis rs1499614 1.000 rs2659903 chr7:66180931 G/A cg12463550 chr7:65579703 CRCP 0.64 5.77 0.3 1.84e-8 Gout; CRC cis rs12137294 0.829 rs1172154 chr1:205220639 T/G cg24159697 chr1:205181237 DSTYK -0.34 -6.08 -0.32 3.39e-9 Red cell distribution width; CRC trans rs2235573 0.527 rs139862 chr22:38351986 T/C cg19894588 chr14:64061835 NA 0.52 7.28 0.37 2.51e-12 Glioblastoma;Glioma; CRC cis rs9640161 0.659 rs77354576 chr7:150013300 A/C cg13722127 chr7:150037890 RARRES2 0.47 7.88 0.4 4.86e-14 Blood protein levels;Circulating chemerin levels; CRC cis rs514406 0.861 rs503015 chr1:53254456 T/C cg08859206 chr1:53392774 SCP2 0.45 6.96 0.36 1.89e-11 Monocyte count; CRC cis rs11583043 0.958 rs11583674 chr1:101396560 C/G cg00063077 chr1:101360652 SLC30A7;EXTL2 0.5 6.75 0.35 6.87e-11 Ulcerative colitis;Inflammatory bowel disease; CRC cis rs936229 0.656 rs2290572 chr15:75130573 A/G cg14664628 chr15:75095509 CSK -0.71 -12.26 -0.56 9.96e-29 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); CRC cis rs28386778 0.897 rs2028567 chr17:61915326 G/A cg11494091 chr17:61959527 GH2 0.63 10.75 0.51 2.7e-23 Prudent dietary pattern; CRC cis rs4819052 0.788 rs13049700 chr21:46701909 G/C cg11663144 chr21:46675770 NA -0.68 -10.66 -0.51 5.41e-23 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs780096 0.546 rs1260320 chr2:27722416 A/G cg27432699 chr2:27873401 GPN1 0.53 8.23 0.41 4.37e-15 Total body bone mineral density; CRC cis rs853679 1.000 rs6905391 chr6:28262686 G/A cg15786705 chr6:28176104 NA 0.55 5.81 0.31 1.45e-8 Depression; CRC trans rs916888 0.610 rs199536 chr17:44820425 T/C cg07870213 chr5:140052090 DND1 -0.62 -8.22 -0.41 4.83e-15 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs10193935 1.000 rs13419669 chr2:42387254 T/C cg27598129 chr2:42591480 NA -0.65 -7.51 -0.38 5.55e-13 Colonoscopy-negative controls vs population controls; CRC cis rs12711979 0.692 rs6751947 chr2:3820739 G/A cg17052675 chr2:3827356 NA -0.57 -10.83 -0.51 1.36e-23 Itch intensity from mosquito bite adjusted by bite size; CRC cis rs13082711 0.595 rs6778612 chr3:27370789 T/C cg02860705 chr3:27208620 NA -0.69 -9.18 -0.45 4.79e-18 Systolic blood pressure;Diastolic blood pressure;Blood pressure; CRC trans rs2055729 0.677 rs59880252 chr8:9741032 C/T cg06636001 chr8:8085503 FLJ10661 0.53 6.7 0.35 9.17e-11 Multiple myeloma (hyperdiploidy); CRC cis rs6500395 1.000 rs9939103 chr16:48592376 G/C cg04672837 chr16:48644449 N4BP1 0.44 6.5 0.34 2.95e-10 Response to tocilizumab in rheumatoid arthritis; CRC cis rs9487051 0.700 rs9400266 chr6:109596193 T/A cg21918786 chr6:109611834 NA -0.41 -7.17 -0.37 4.84e-12 Reticulocyte fraction of red cells; CRC trans rs7613875 0.600 rs2624832 chr3:50030858 C/T cg21659725 chr3:3221576 CRBN 0.44 6.39 0.33 5.6e-10 Body mass index; CRC cis rs3015497 0.646 rs2934687 chr14:51111889 G/A cg26011998 chr14:51135199 SAV1 -0.44 -5.67 -0.3 3.08e-8 Mean platelet volume; CRC cis rs10946940 0.930 rs12215012 chr6:27507494 C/G cg02683197 chr6:28174875 NA -0.52 -7.14 -0.37 6.1e-12 Systemic lupus erythematosus; CRC cis rs9303280 0.870 rs6503524 chr17:38069809 C/T cg00129232 chr17:37814104 STARD3 0.46 7.28 0.37 2.45e-12 Self-reported allergy; CRC cis rs9325144 0.560 rs10876005 chr12:39126149 C/G cg26384229 chr12:38710491 ALG10B -0.53 -7.88 -0.4 4.85e-14 Morning vs. evening chronotype; CRC cis rs4319547 0.656 rs28730465 chr12:122863864 A/C cg05707623 chr12:122985044 ZCCHC8 0.78 9.46 0.46 6.15e-19 Body mass index; CRC trans rs916888 0.821 rs415430 chr17:44859144 C/T cg22433210 chr17:43662623 NA -0.82 -9.07 -0.45 1.11e-17 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs6582630 0.638 rs61931383 chr12:38513845 G/A cg13010199 chr12:38710504 ALG10B -0.41 -5.95 -0.31 6.8e-9 Drug-induced liver injury (flucloxacillin); CRC cis rs1552244 0.882 rs66559400 chr3:10012551 G/A cg16606324 chr3:10149918 C3orf24 0.62 8.02 0.4 1.87e-14 Alzheimer's disease; CRC cis rs13108904 0.557 rs1250086 chr4:1248051 G/A cg05025164 chr4:1340916 KIAA1530 -0.5 -6.88 -0.35 2.96e-11 Obesity-related traits; CRC cis rs7586879 0.598 rs6545806 chr2:25124348 G/A cg04586622 chr2:25135609 ADCY3 -0.56 -10.45 -0.5 3.03e-22 Body mass index; CRC trans rs10982213 0.830 rs2274163 chr9:117188714 C/T cg23084309 chr19:6280164 MLLT1 0.38 6.06 0.32 3.72e-9 Interleukin-6 levels; CRC cis rs7666738 0.716 rs2865982 chr4:99031661 T/G cg05340658 chr4:99064831 C4orf37 0.61 9.42 0.46 8.23e-19 Colonoscopy-negative controls vs population controls; CRC cis rs10504229 0.569 rs75466737 chr8:58055034 A/G cg02725872 chr8:58115012 NA -0.56 -7.63 -0.39 2.61e-13 Developmental language disorder (linguistic errors); CRC cis rs10911232 0.507 rs4596846 chr1:182976034 C/T ch.1.3577855R chr1:183094577 LAMC1 0.87 15.17 0.64 9.22e-40 Hypertriglyceridemia; CRC cis rs9788333 0.962 rs12584792 chr13:21887208 C/T cg06138931 chr13:21896616 NA 0.54 8.48 0.42 7.47e-16 Thiazide-induced adverse metabolic effects in hypertensive patients; CRC cis rs736408 0.660 rs2019065 chr3:52809525 C/T cg15147215 chr3:52552868 STAB1 0.6 10.19 0.49 2.21e-21 Bipolar disorder; CRC cis rs3768617 0.510 rs2296292 chr1:183086757 A/C ch.1.3577855R chr1:183094577 LAMC1 0.89 15.86 0.66 1.84e-42 Fuchs's corneal dystrophy; CRC cis rs9322193 0.923 rs62439842 chr6:149996983 G/A cg07701084 chr6:150067640 NUP43 0.56 8.25 0.41 3.79e-15 Lung cancer; CRC cis rs7666738 0.830 rs4699577 chr4:98846513 G/A cg17366294 chr4:99064904 C4orf37 0.42 6.85 0.35 3.7e-11 Colonoscopy-negative controls vs population controls; CRC trans rs2303319 0.504 rs55638078 chr2:162524997 T/C cg03757145 chr4:76555832 CDKL2 -0.66 -5.97 -0.31 5.99e-9 Cognitive function; CRC cis rs9818758 0.607 rs34580506 chr3:49113713 C/A cg00383909 chr3:49044727 WDR6 1.31 12.49 0.57 1.48e-29 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; CRC cis rs1401999 1.000 rs1402003 chr3:183642879 C/T cg20387954 chr3:183756860 HTR3D 0.42 7.18 0.37 4.59e-12 Anterior chamber depth; CRC cis rs35146811 0.731 rs2257213 chr7:99810113 T/C cg13334819 chr7:99746414 C7orf59 0.55 7.17 0.37 4.92e-12 Coronary artery disease; CRC cis rs1881396 0.945 rs62141291 chr2:27784034 C/T cg27432699 chr2:27873401 GPN1 0.64 8.42 0.42 1.17e-15 Nonalcoholic fatty liver disease; CRC cis rs9291683 0.546 rs7442336 chr4:10045783 G/A cg00071950 chr4:10020882 SLC2A9 0.63 11.19 0.52 7.86e-25 Bone mineral density; CRC cis rs9611565 0.512 rs139562 chr22:42196684 G/C cg06481639 chr22:41940642 POLR3H -0.61 -6.81 -0.35 4.78e-11 Vitiligo; CRC cis rs60871478 1.000 rs12531530 chr7:827366 T/C cg13844804 chr7:814759 HEATR2 0.69 8.18 0.41 6.11e-15 Cerebrospinal P-tau181p levels; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg18570997 chr7:129710291 KLHDC10 0.49 7.49 0.38 6.3e-13 Intelligence (multi-trait analysis); CRC cis rs2153535 0.580 rs6597327 chr6:8482157 G/A cg21535247 chr6:8435926 SLC35B3 0.5 7.51 0.38 5.54e-13 Motion sickness; CRC cis rs561341 1.000 rs72823787 chr17:30283809 A/T cg19193384 chr17:30244184 NA -0.65 -7.5 -0.38 6.06e-13 Hip circumference adjusted for BMI; CRC cis rs17270561 0.609 rs1892245 chr6:25764833 G/T cg16482183 chr6:26056742 HIST1H1C 0.71 9.0 0.44 1.79e-17 Iron status biomarkers; CRC cis rs6570726 0.791 rs621382 chr6:145799144 T/C cg13319975 chr6:146136371 FBXO30 -0.46 -6.84 -0.35 3.81e-11 Lobe attachment (rater-scored or self-reported); CRC cis rs7811142 0.775 rs1059129 chr7:99926522 A/G cg00814883 chr7:100076585 TSC22D4 -0.65 -8.31 -0.42 2.57e-15 Platelet count; CRC cis rs2404602 0.647 rs4886840 chr15:77179002 A/G cg03037974 chr15:76606532 NA -0.55 -8.22 -0.41 4.68e-15 Blood metabolite levels; CRC cis rs3096299 0.685 rs12446145 chr16:89542695 C/T cg08392591 chr16:89556376 ANKRD11 0.42 5.75 0.3 2.09e-8 Multiple myeloma (IgH translocation); CRC cis rs4363385 0.818 rs4845512 chr1:152995241 C/T cg25856811 chr1:152973957 SPRR3 -0.24 -6.73 -0.35 7.68e-11 Inflammatory skin disease; CRC cis rs6570726 0.905 rs1355146 chr6:145781741 A/C cg23711669 chr6:146136114 FBXO30 -0.63 -10.59 -0.5 9.72e-23 Lobe attachment (rater-scored or self-reported); CRC cis rs10504229 0.593 rs75047131 chr8:58001320 A/G cg08219700 chr8:58056026 NA 0.55 6.44 0.33 4.2e-10 Developmental language disorder (linguistic errors); CRC cis rs9287719 0.967 rs7600728 chr2:10739999 A/G cg00105475 chr2:10696890 NA 0.45 7.3 0.37 2.19e-12 Prostate cancer; CRC cis rs6582630 0.593 rs7299329 chr12:38447943 G/C cg13010199 chr12:38710504 ALG10B 0.5 6.63 0.34 1.37e-10 Drug-induced liver injury (flucloxacillin); CRC cis rs11677416 1.000 rs1040193 chr2:113530099 C/T cg27083787 chr2:113543245 IL1A 0.47 6.71 0.35 8.5e-11 Response to antipsychotic treatment in schizophrenia (working memory); CRC cis rs7258465 1.000 rs10409505 chr19:18590251 C/G cg06462663 chr19:18546047 ISYNA1 0.48 7.36 0.38 1.47e-12 Breast cancer; CRC cis rs4843747 0.671 rs4072871 chr16:88106614 C/T cg03395651 chr16:88107091 BANP 0.61 8.25 0.41 3.73e-15 Menopause (age at onset); CRC cis rs2011503 0.941 rs4808944 chr19:19426613 A/C cg11584989 chr19:19387371 SF4 0.56 6.4 0.33 5.2e-10 Bipolar disorder; CRC trans rs459571 1.000 rs2810489 chr9:136922700 C/T cg09836344 chr4:1243392 C4orf42;CTBP1 -0.83 -11.68 -0.54 1.34e-26 Platelet distribution width; CRC cis rs1799949 0.602 rs8176235 chr17:41219560 C/T cg25072359 chr17:41440525 NA 0.43 5.83 0.31 1.35e-8 Menopause (age at onset); CRC cis rs1881797 1.000 rs12081895 chr1:247686666 C/G cg18198730 chr1:247681584 NA 0.54 8.43 0.42 1.08e-15 Acute lymphoblastic leukemia (childhood); CRC cis rs10028773 0.515 rs9994488 chr4:120587781 C/T cg09307838 chr4:120376055 NA 0.57 8.58 0.43 3.87e-16 Educational attainment; CRC cis rs9902453 0.904 rs7218379 chr17:28402737 C/T cg26525008 chr17:28256777 EFCAB5;SSH2 -0.69 -11.43 -0.53 1.03e-25 Coffee consumption (cups per day); CRC cis rs9733 0.527 rs11204694 chr1:150653391 G/A cg17724175 chr1:150552817 MCL1 0.61 9.78 0.47 5.24e-20 Tonsillectomy; CRC cis rs7666738 0.830 rs1426667 chr4:98949772 T/C cg17366294 chr4:99064904 C4orf37 0.43 7.34 0.38 1.69e-12 Colonoscopy-negative controls vs population controls; CRC cis rs7666738 0.830 rs957742 chr4:99029409 C/T cg05340658 chr4:99064831 C4orf37 0.61 9.42 0.46 8.23e-19 Colonoscopy-negative controls vs population controls; CRC cis rs4660306 0.961 rs7539253 chr1:45947420 C/T cg03123370 chr1:45965343 CCDC163P;MMACHC -0.56 -7.85 -0.4 5.99e-14 Homocysteine levels; CRC cis rs2475553 0.520 rs62437129 chr6:158655757 T/G cg07165851 chr6:158734300 TULP4 0.55 6.23 0.32 1.44e-9 Lipoprotein (a) - cholesterol levels; CRC cis rs896854 0.684 rs10099059 chr8:95986972 G/C cg09323728 chr8:95962352 TP53INP1 -0.43 -7.13 -0.37 6.43e-12 Type 2 diabetes; CRC cis rs7613875 0.580 rs2624819 chr3:50010571 G/T cg05623727 chr3:50126028 RBM5 0.57 10.07 0.49 5.62e-21 Body mass index; CRC cis rs4974559 0.739 rs28573879 chr4:1285910 C/T cg02980000 chr4:1222292 CTBP1 0.71 7.97 0.4 2.59e-14 Systolic blood pressure; CRC cis rs35306767 0.716 rs34487581 chr10:897201 G/A cg20503657 chr10:835505 NA 1.21 14.74 0.63 4.02e-38 Eosinophil percentage of granulocytes; CRC cis rs9916302 0.706 rs7208252 chr17:37584368 A/G cg00129232 chr17:37814104 STARD3 -0.58 -7.18 -0.37 4.56e-12 Glomerular filtration rate (creatinine); CRC cis rs11098499 0.954 rs13151285 chr4:120314741 C/A cg09307838 chr4:120376055 NA 0.71 10.93 0.52 6.41e-24 Corneal astigmatism; CRC cis rs7394190 0.748 rs4114992 chr10:75566829 A/G cg07699608 chr10:75541558 CHCHD1 0.58 6.25 0.33 1.28e-9 Incident atrial fibrillation; CRC cis rs4889855 0.505 rs7501740 chr17:78610345 A/G cg16591659 chr17:78472290 NA -0.43 -6.16 -0.32 2.08e-9 Fractional excretion of uric acid; CRC cis rs8180040 0.593 rs12715421 chr3:47084859 A/G cg10298567 chr3:47292165 KIF9 -0.39 -6.09 -0.32 3.13e-9 Colorectal cancer; CRC cis rs6951245 0.935 rs112554101 chr7:1065535 A/G cg27454412 chr7:1067447 C7orf50 0.5 5.83 0.31 1.31e-8 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC trans rs7395662 1.000 rs6485882 chr11:48592435 C/G cg21153622 chr11:89784906 NA 0.44 7.06 0.36 9.64e-12 HDL cholesterol; CRC cis rs300703 0.515 rs300695 chr2:182644 C/A cg21211680 chr2:198530 NA -0.69 -9.12 -0.45 7.78e-18 Blood protein levels; CRC cis rs1003719 0.715 rs9980353 chr21:38558812 T/G cg10648535 chr21:38446584 PIGP;TTC3 -0.47 -6.62 -0.34 1.49e-10 Eye color traits; CRC cis rs12887734 0.524 rs722637 chr14:104261723 G/T cg08213375 chr14:104286397 PPP1R13B -0.5 -8.5 -0.42 6.84e-16 Schizophrenia;Autism spectrum disorder or schizophrenia; CRC cis rs12580194 0.593 rs73118998 chr12:55736659 T/C cg19537932 chr12:55886519 OR6C68 -0.65 -8.42 -0.42 1.16e-15 Cancer; CRC cis rs9393692 0.905 rs6908328 chr6:26292855 C/A cg05868516 chr6:26286170 HIST1H4H 0.39 5.62 0.3 3.99e-8 Educational attainment; CRC trans rs2727020 0.554 rs7111711 chr11:49557880 G/A cg15704280 chr7:45808275 SEPT13 -0.76 -10.12 -0.49 3.87e-21 Coronary artery disease; CRC cis rs13118159 0.527 rs1250119 chr4:1261336 G/A cg20887711 chr4:1340912 KIAA1530 -0.73 -10.2 -0.49 2.1e-21 Longevity; CRC cis rs10760123 1 rs10760123 chr9:123650534 T/G cg00246817 chr9:123691163 NA -0.47 -5.97 -0.31 6.22e-9 Allergic disease (asthma, hay fever or eczema); CRC cis rs9768139 0.901 rs56113702 chr7:158117938 C/T cg25566285 chr7:158114605 PTPRN2 -0.59 -10.12 -0.49 3.88e-21 Calcium levels; CRC cis rs208520 0.754 rs12204635 chr6:66740779 C/A cg07460842 chr6:66804631 NA 1.06 14.78 0.63 2.91e-38 Exhaled nitric oxide output; CRC cis rs2842992 0.789 rs7758895 chr6:160193465 T/C cg19482086 chr6:160211437 TCP1;MRPL18 0.73 9.71 0.47 9.15e-20 Age-related macular degeneration (geographic atrophy); CRC cis rs6964587 0.839 rs11767135 chr7:91551245 T/G cg17063962 chr7:91808500 NA -0.75 -12.81 -0.58 9.21e-31 Breast cancer; CRC cis rs35306767 0.903 rs61833260 chr10:975148 T/G cg26597838 chr10:835615 NA 1.09 13.04 0.58 1.33e-31 Eosinophil percentage of granulocytes; CRC trans rs8002861 0.875 rs12869697 chr13:44439169 T/C cg17145862 chr1:211918768 LPGAT1 -0.67 -12.34 -0.56 5.23e-29 Leprosy; CRC cis rs4727027 0.870 rs13237714 chr7:148884083 A/G cg23583168 chr7:148888333 NA -0.92 -15.77 -0.66 4.2e-42 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC cis rs13108904 0.650 rs3796618 chr4:1349602 T/A cg05025164 chr4:1340916 KIAA1530 0.43 6.58 0.34 1.86e-10 Obesity-related traits; CRC cis rs2160860 0.930 rs2729484 chr8:39812080 T/C cg11363097 chr8:39792086 IDO2 -0.39 -6.44 -0.33 4.18e-10 Blood metabolite levels; CRC cis rs9527 0.590 rs1541213 chr10:104885330 A/G cg15744005 chr10:104629667 AS3MT -0.31 -6.1 -0.32 3.03e-9 Arsenic metabolism; CRC cis rs7731657 0.510 rs2569257 chr5:130245468 A/G cg08523029 chr5:130500466 HINT1 -0.49 -6.21 -0.32 1.61e-9 Fasting plasma glucose; CRC cis rs12134245 0.874 rs34842487 chr1:92021611 C/T cg02896835 chr1:92012615 NA -0.48 -7.67 -0.39 1.92e-13 Breast cancer; CRC cis rs2070488 0.775 rs9838614 chr3:38537671 A/C cg01465620 chr3:38496096 LOC100128640;ACVR2B -0.66 -10.89 -0.51 8.97e-24 Electrocardiographic conduction measures; CRC cis rs1799949 1.000 rs34534709 chr17:41302940 C/G cg01879757 chr17:41196368 BRCA1 -0.42 -6.24 -0.33 1.31e-9 Menopause (age at onset); CRC cis rs6543140 0.601 rs78178597 chr2:103023596 G/T cg09003973 chr2:102972529 NA 0.53 6.56 0.34 2.05e-10 Blood protein levels; CRC cis rs875971 0.862 rs11773628 chr7:65982631 G/T cg11764359 chr7:65958608 NA -0.61 -9.49 -0.46 4.73e-19 Aortic root size; CRC cis rs6502050 0.765 rs55905076 chr17:80105441 G/A cg22110888 chr17:80059540 CCDC57 0.4 6.35 0.33 7.32e-10 Life satisfaction; CRC trans rs853679 0.546 rs34295134 chr6:27828151 T/A cg16898833 chr6:26189333 HIST1H4D 0.67 6.03 0.32 4.43e-9 Depression; CRC cis rs1348850 0.567 rs880898 chr2:178532470 C/T cg02961200 chr2:178257176 LOC100130691;AGPS 0.58 8.28 0.42 3.05e-15 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs7659604 0.967 rs28529384 chr4:122664215 T/C cg06713675 chr4:122721982 EXOSC9 -0.38 -6.28 -0.33 1.05e-9 Type 2 diabetes; CRC cis rs7617773 1.000 rs9832957 chr3:48185266 A/G cg11946769 chr3:48343235 NME6 -0.52 -7.06 -0.36 9.72e-12 Coronary artery disease; CRC cis rs10871290 0.551 rs3863435 chr16:74465396 C/G cg01733217 chr16:74700730 RFWD3 -0.67 -10.79 -0.51 1.98e-23 Breast cancer; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg05716599 chr10:64892916 NRBF2 0.39 5.99 0.31 5.5e-9 Liver disease severity in Alagille syndrome; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg15515537 chr12:133067734 FBRSL1 0.39 6.16 0.32 2.17e-9 Intelligence (multi-trait analysis); CRC cis rs4930103 0.935 rs2839698 chr11:2018853 G/A cg23202291 chr11:1979235 NA 0.47 6.56 0.34 2.06e-10 DNA methylation (parent-of-origin);DNA methylation (variation); CRC cis rs1552244 1.000 rs6442146 chr3:10073544 C/T cg13047869 chr3:10149882 C3orf24 0.52 7.32 0.37 1.86e-12 Alzheimer's disease; CRC cis rs6951245 0.935 rs61753396 chr7:1105372 A/G cg04025307 chr7:1156635 C7orf50 0.66 7.09 0.36 8.05e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs2153535 0.580 rs9405391 chr6:8466548 C/T cg21535247 chr6:8435926 SLC35B3 0.5 7.53 0.38 4.89e-13 Motion sickness; CRC cis rs8180040 0.934 rs12630641 chr3:47534836 G/T cg27129171 chr3:47204927 SETD2 0.52 8.07 0.41 1.29e-14 Colorectal cancer; CRC cis rs875971 1.000 rs1182882 chr7:65562063 C/T cg18912574 chr7:65842487 NCRNA00174 -0.37 -6.49 -0.34 3.13e-10 Aortic root size; CRC cis rs9611565 0.659 rs12484175 chr22:41953739 A/C cg17554472 chr22:41940697 POLR3H -0.56 -5.99 -0.31 5.59e-9 Vitiligo; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg21762534 chr19:17580568 SLC27A1 0.44 7.16 0.37 5.35e-12 Liver disease severity in Alagille syndrome; CRC cis rs2249625 0.545 rs2496505 chr6:72891063 C/G cg18830697 chr6:72922368 RIMS1 -0.4 -8.07 -0.41 1.32e-14 Acute urticaria and angioedema (non-steroidal anti-inflammatory drug-induced); CRC cis rs863345 0.604 rs11264999 chr1:158488860 T/C cg12129480 chr1:158549410 OR10X1 -0.29 -6.01 -0.31 4.98e-9 Pneumococcal bacteremia; CRC cis rs28386778 0.897 rs1470697 chr17:61799840 T/C cg25654072 chr17:61904446 PSMC5;FTSJ3 0.72 11.05 0.52 2.36e-24 Prudent dietary pattern; CRC cis rs10504229 1.000 rs115548028 chr8:58170672 T/C cg02290350 chr8:58132656 NA -0.42 -5.96 -0.31 6.62e-9 Developmental language disorder (linguistic errors); CRC cis rs10751667 0.600 rs11246376 chr11:999622 C/T ch.11.42038R chr11:967971 AP2A2 0.59 9.38 0.46 1.1e-18 Alzheimer's disease (late onset); CRC trans rs875971 0.660 rs2191268 chr7:66110224 C/T cg22242963 chr19:48837349 TMEM143 -0.4 -6.49 -0.34 3.16e-10 Aortic root size; CRC cis rs12142240 0.698 rs68012736 chr1:46839510 A/G cg14993813 chr1:46806288 NSUN4 -0.48 -6.05 -0.32 3.98e-9 Menopause (age at onset); CRC cis rs9341808 0.718 rs9352803 chr6:80864667 G/T cg08355045 chr6:80787529 NA 0.42 6.79 0.35 5.2e-11 Sitting height ratio; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg14614403 chr9:20621888 MLLT3 0.41 6.44 0.33 4.18e-10 Liver disease severity in Alagille syndrome; CRC cis rs892961 0.932 rs66886702 chr17:75412714 G/A cg05865280 chr17:75406074 SEPT9 0.63 14.51 0.62 3.27e-37 Airflow obstruction; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg15988263 chr1:44412313 IPO13 0.45 6.29 0.33 1e-9 Anxiety disorder; CRC trans rs2797369 0.882 rs4470856 chr6:101614466 C/A cg26346621 chr12:6873348 NA -0.38 -6.1 -0.32 2.96e-9 Renal function-related traits (eGRFcrea); CRC cis rs7224737 0.957 rs6503687 chr17:40295397 G/A cg02450064 chr17:40260053 DHX58 -0.42 -6.13 -0.32 2.54e-9 Fibrinogen levels; CRC cis rs6502050 0.835 rs9901076 chr17:80170020 G/A cg09264619 chr17:80180166 NA -0.34 -5.63 -0.3 3.83e-8 Life satisfaction; CRC cis rs17270561 0.636 rs2070642 chr6:25831212 G/A cg16482183 chr6:26056742 HIST1H1C 0.62 8.37 0.42 1.73e-15 Iron status biomarkers; CRC cis rs2160860 0.965 rs2543047 chr8:39819666 A/G cg11363097 chr8:39792086 IDO2 0.36 5.83 0.31 1.33e-8 Blood metabolite levels; CRC cis rs7212590 0.748 rs7220187 chr17:57897609 C/T cg10252138 chr17:58120427 NA -0.53 -5.61 -0.3 4.22e-8 Granulocyte percentage of myeloid white cells;Monocyte count;Monocyte percentage of white cells; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg23147149 chr17:2304328 MNT 0.5 7.34 0.38 1.67e-12 Response to antipsychotic treatment; CRC cis rs7666738 0.830 rs6823718 chr4:99063202 C/T cg17366294 chr4:99064904 C4orf37 0.44 7.47 0.38 7.31e-13 Colonoscopy-negative controls vs population controls; CRC cis rs561341 1.000 rs576985 chr17:30323323 C/T cg12193833 chr17:30244370 NA -0.76 -8.87 -0.44 4.62e-17 Hip circumference adjusted for BMI; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg15142938 chr11:59383312 OSBP 0.42 6.09 0.32 3.14e-9 Intelligence (multi-trait analysis); CRC cis rs733175 0.855 rs10022499 chr4:10006537 C/A cg00071950 chr4:10020882 SLC2A9 0.39 5.68 0.3 2.9e-8 Psychosis and Alzheimer's disease; CRC cis rs11622475 0.677 rs7145372 chr14:104359121 A/G cg20488157 chr14:104394430 TDRD9 -0.47 -6.35 -0.33 7.21e-10 Bipolar disorder; CRC cis rs10751667 0.666 rs6597960 chr11:977036 C/T cg23136738 chr11:925521 AP2A2 -0.42 -7.09 -0.36 8.19e-12 Alzheimer's disease (late onset); CRC trans rs877282 0.891 rs11253406 chr10:796297 G/A cg22713356 chr15:30763199 NA 1.34 16.68 0.68 1.08e-45 Uric acid levels; CRC cis rs9733 0.596 rs12072339 chr1:150686099 A/G cg10589385 chr1:150898437 SETDB1 0.28 5.96 0.31 6.66e-9 Tonsillectomy; CRC cis rs9522267 0.535 rs9522304 chr13:112237316 C/T cg26182253 chr13:112236782 NA 0.31 6.23 0.32 1.4e-9 Hepatitis; CRC cis rs1555322 0.505 rs591590 chr20:33866028 A/G cg13662093 chr20:33865505 NA -0.49 -6.54 -0.34 2.41e-10 Attention deficit hyperactivity disorder; CRC cis rs1153858 0.887 rs7171163 chr15:45636395 A/C cg10760299 chr15:45669010 GATM 0.5 7.97 0.4 2.67e-14 Homoarginine levels; CRC cis rs116095464 0.510 rs10057501 chr5:239545 T/C cg22857025 chr5:266934 NA -1.25 -16.43 -0.67 1.02e-44 Breast cancer; CRC cis rs7666738 0.830 rs10021044 chr4:99002488 A/T cg05340658 chr4:99064831 C4orf37 0.61 9.54 0.47 3.44e-19 Colonoscopy-negative controls vs population controls; CRC cis rs4665809 1.000 rs6709595 chr2:26259885 A/G cg27170947 chr2:26402098 FAM59B -0.44 -5.89 -0.31 9.43e-9 Gut microbiome composition (summer); CRC cis rs4664293 0.669 rs1549387 chr2:160417540 A/G cg08347373 chr2:160653686 CD302 0.41 6.9 0.36 2.6e-11 Monocyte percentage of white cells; CRC cis rs4713118 0.527 rs35949862 chr6:28115367 A/G cg15845792 chr6:28175446 NA 1.04 13.89 0.61 7.67e-35 Parkinson's disease; CRC cis rs6866344 0.697 rs11748497 chr5:178130012 C/G cg03877680 chr5:178157825 ZNF354A 0.77 10.88 0.51 9.71e-24 Neutrophil percentage of white cells; CRC cis rs6741819 1.000 rs72781779 chr2:7145953 G/A cg27144453 chr2:7172511 RNF144A -0.42 -6.29 -0.33 1e-9 Response to antipsychotic treatment; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg18313530 chr11:111749763 C11orf1;FDXACB1 0.38 6.12 0.32 2.63e-9 Intelligence (multi-trait analysis); CRC cis rs57221529 0.766 rs72706608 chr5:559203 C/T cg09021430 chr5:549028 NA -0.72 -8.17 -0.41 6.5e-15 Lung disease severity in cystic fibrosis; CRC cis rs910316 1.000 rs7303 chr14:75520065 T/C cg08847533 chr14:75593920 NEK9 0.95 18.13 0.71 2.1e-51 Height; CRC cis rs4268898 1.000 rs6746005 chr2:24434345 G/A cg06627628 chr2:24431161 ITSN2 0.5 7.39 0.38 1.19e-12 Asthma; CRC cis rs7208859 0.673 rs11080135 chr17:29176481 A/G cg14008862 chr17:28927542 LRRC37B2 0.55 5.74 0.3 2.1e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs79349575 0.783 rs903567 chr17:46980318 C/T cg00947319 chr17:47005597 UBE2Z -0.34 -5.91 -0.31 8.38e-9 Type 2 diabetes; CRC cis rs7659604 1.000 rs34952897 chr4:122664409 C/T cg06713675 chr4:122721982 EXOSC9 -0.38 -6.25 -0.33 1.27e-9 Type 2 diabetes; CRC cis rs10504229 0.639 rs2291764 chr8:58142943 A/C cg22535103 chr8:58192502 C8orf71 -0.81 -9.06 -0.45 1.15e-17 Developmental language disorder (linguistic errors); CRC cis rs13191362 0.872 rs35672319 chr6:163245464 C/A cg21926612 chr6:163149169 PACRG;PARK2 0.7 8.94 0.44 2.78e-17 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs870825 0.929 rs72689254 chr4:185589941 C/T cg04058563 chr4:185651563 MLF1IP 0.58 6.08 0.32 3.27e-9 Blood protein levels; CRC cis rs854572 1.000 rs854572 chr7:94954696 C/G cg01874867 chr7:94954059 PON1 -0.68 -11.47 -0.53 7.67e-26 Paraoxonase activity; CRC cis rs3733585 0.578 rs6837224 chr4:9955255 G/T cg11266682 chr4:10021025 SLC2A9 -0.47 -9.59 -0.47 2.27e-19 Cleft plate (environmental tobacco smoke interaction); CRC cis rs13323323 0.728 rs1004631 chr3:44592979 T/G cg14768256 chr3:44754587 ZNF502 -0.48 -5.99 -0.31 5.36e-9 IgG glycosylation; CRC cis rs8067545 0.611 rs2703800 chr17:20086562 C/T cg13482628 chr17:19912719 NA 0.45 7.17 0.37 4.95e-12 Schizophrenia; CRC cis rs16924133 0.793 rs67204237 chr11:33174541 G/A cg05567920 chr11:33183001 CSTF3 -0.75 -5.66 -0.3 3.31e-8 Anger; CRC cis rs6502050 0.805 rs11651863 chr17:80084539 T/C cg22110888 chr17:80059540 CCDC57 -0.41 -6.46 -0.34 3.78e-10 Life satisfaction; CRC cis rs7666738 0.800 rs7684523 chr4:98983175 G/T cg05340658 chr4:99064831 C4orf37 0.6 9.41 0.46 8.57e-19 Colonoscopy-negative controls vs population controls; CRC cis rs929354 0.742 rs2006844 chr7:157002851 G/A cg05182265 chr7:156933206 UBE3C -0.76 -14.49 -0.62 3.8e-37 Body mass index; CRC trans rs4841899 0.777 rs1980852 chr9:137422031 A/G cg27569887 chr3:30045896 RBMS3 0.34 6.18 0.32 1.87e-9 Stem cell factor levels; CRC trans rs6703335 0.870 rs10803142 chr1:243598234 A/G cg05210398 chr12:132470983 EP400 0.44 6.23 0.32 1.42e-9 Schizophrenia;Schizophrenia, schizoaffective disorder or bipolar disorder; CRC cis rs13082711 0.595 rs34453788 chr3:27330153 T/C cg02860705 chr3:27208620 NA 0.83 10.98 0.52 4.27e-24 Systolic blood pressure;Diastolic blood pressure;Blood pressure; CRC cis rs68170813 0.523 rs12532447 chr7:106940476 C/T cg02696742 chr7:106810147 HBP1 -0.59 -6.75 -0.35 6.73e-11 Coronary artery disease; CRC trans rs7819412 0.775 rs2898257 chr8:10935368 A/C cg16141378 chr3:129829833 LOC729375 0.46 6.55 0.34 2.21e-10 Triglycerides; CRC cis rs35146811 0.735 rs6948729 chr7:99787372 A/G cg13334819 chr7:99746414 C7orf59 -0.51 -6.72 -0.35 7.79e-11 Coronary artery disease; CRC cis rs12541635 0.966 rs62525736 chr8:107000638 G/C cg10147462 chr8:107024639 NA 0.45 7.28 0.37 2.43e-12 Age of smoking initiation; CRC cis rs394563 0.901 rs448874 chr6:149796967 C/T cg11245181 chr6:149772854 ZC3H12D -0.51 -8.49 -0.42 7.11e-16 Dupuytren's disease; CRC cis rs2072510 0.593 rs2540493 chr12:96415842 A/C cg22491680 chr12:96389547 HAL -0.46 -5.73 -0.3 2.23e-8 Metabolite levels (small molecules and protein measures); CRC cis rs6951245 0.872 rs11768486 chr7:1101290 C/A cg22907277 chr7:1156413 C7orf50 0.73 7.68 0.39 1.78e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs4713118 0.662 rs9468274 chr6:28026077 G/T cg15786705 chr6:28176104 NA 0.69 9.22 0.45 3.64e-18 Parkinson's disease; CRC cis rs9837602 1.000 rs1038294 chr3:99503728 A/G cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G -0.47 -5.62 -0.3 4.07e-8 Breast cancer; CRC cis rs2274273 0.805 rs7159808 chr14:55624327 G/T cg23234261 chr14:55582407 NA -0.29 -5.77 -0.3 1.86e-8 Protein biomarker; CRC cis rs7224685 0.501 rs781848 chr17:3958105 A/C cg09695851 chr17:3907499 NA 0.74 12.97 0.58 2.42e-31 Type 2 diabetes; CRC cis rs9398803 0.865 rs1361108 chr6:126767600 C/T cg19875578 chr6:126661172 C6orf173 0.44 6.21 0.32 1.64e-9 Male-pattern baldness; CRC trans rs2228479 0.702 rs17177891 chr16:89799950 C/T cg24644049 chr4:85504048 CDS1 0.9 7.37 0.38 1.39e-12 Skin colour saturation; CRC cis rs10504229 0.683 rs7835498 chr8:58129780 A/C cg05313129 chr8:58192883 C8orf71 -0.43 -6.11 -0.32 2.74e-9 Developmental language disorder (linguistic errors); CRC cis rs932541 1.000 rs6105609 chr20:16457330 A/G cg17003395 chr20:16555519 KIF16B 0.41 5.63 0.3 3.82e-8 Intelligence; CRC cis rs10504229 1.000 rs67243305 chr8:58174958 G/A cg02290350 chr8:58132656 NA -0.42 -5.87 -0.31 1.09e-8 Developmental language disorder (linguistic errors); CRC cis rs853679 0.517 rs9368558 chr6:28133306 A/G cg15786705 chr6:28176104 NA 0.78 9.83 0.48 3.57e-20 Depression; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg21961583 chr2:170684455 UBR3 0.43 6.14 0.32 2.32e-9 Response to antipsychotic treatment; CRC cis rs1256061 0.624 rs1152578 chr14:64697037 T/C cg23250157 chr14:64679961 SYNE2 0.46 7.21 0.37 3.79e-12 Hemoglobin concentration;Red blood cell count;Hematocrit; CRC cis rs73001065 0.591 rs2285626 chr19:19467545 C/T cg03709012 chr19:19516395 GATAD2A 0.78 7.74 0.39 1.22e-13 LDL cholesterol; CRC cis rs12594515 0.967 rs12595138 chr15:45986108 G/C cg22117107 chr15:45993392 NA -0.44 -8.88 -0.44 4.52e-17 Waist circumference;Weight; CRC cis rs1707322 1.000 rs11211248 chr1:46476844 A/G cg06784218 chr1:46089804 CCDC17 0.52 9.18 0.45 4.97e-18 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs7937682 0.575 rs11604704 chr11:111764396 G/A cg09085632 chr11:111637200 PPP2R1B 0.94 15.52 0.65 3.71e-41 Primary sclerosing cholangitis; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg01394034 chr12:98909208 TMPO;LOC100128191 0.37 5.97 0.31 6.06e-9 Liver disease severity in Alagille syndrome; CRC cis rs10927875 0.832 rs4661342 chr1:16160773 C/G cg21385522 chr1:16154831 NA -0.89 -10.87 -0.51 1.05e-23 Dilated cardiomyopathy; CRC cis rs2976388 0.609 rs1469811 chr8:143787999 C/T cg20041105 chr8:143859282 LYNX1 0.46 8.14 0.41 8.2e-15 Urinary tract infection frequency; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg02063360 chr14:105452560 C14orf79 0.46 6.59 0.34 1.79e-10 Response to antipsychotic treatment; CRC cis rs11971779 0.680 rs3924296 chr7:139041927 T/C cg23387468 chr7:139079360 LUC7L2 0.41 7.04 0.36 1.14e-11 Diisocyanate-induced asthma; CRC cis rs7246657 0.943 rs10404920 chr19:37881556 T/C cg23950597 chr19:37808831 NA -0.54 -6.5 -0.34 2.93e-10 Coronary artery calcification; CRC cis rs6429082 0.764 rs291377 chr1:235695186 C/T cg26050004 chr1:235667680 B3GALNT2 -0.51 -6.82 -0.35 4.38e-11 Adiposity; CRC cis rs807029 0.577 rs3740490 chr10:102756743 G/C cg04662943 chr10:102668895 NA 0.62 7.26 0.37 2.76e-12 Ejection fraction in Tripanosoma cruzi seropositivity; CRC cis rs875971 0.862 rs801194 chr7:66028495 T/C cg11764359 chr7:65958608 NA -0.58 -8.7 -0.43 1.62e-16 Aortic root size; CRC cis rs6951245 0.554 rs10270249 chr7:1151886 G/T cg22907277 chr7:1156413 C7orf50 0.82 10.67 0.51 5.24e-23 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs7849270 1.000 rs2541161 chr9:131884802 C/T cg13538475 chr9:131942899 NA 0.32 6.27 0.33 1.13e-9 Blood metabolite ratios; CRC cis rs6912958 0.547 rs451089 chr6:88041859 A/G cg12350822 chr6:88032061 C6orf162;GJB7 0.49 9.97 0.48 1.28e-20 Monocyte percentage of white cells; CRC cis rs10463316 0.862 rs7700650 chr5:150776473 C/T cg03212797 chr5:150827313 SLC36A1 -0.49 -7.82 -0.4 7.31e-14 Metabolite levels (Pyroglutamine); CRC cis rs11229555 0.645 rs11229429 chr11:58180872 G/A cg15696309 chr11:58395628 NA -0.81 -10.31 -0.49 8.83e-22 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; CRC cis rs9611565 0.659 rs28530678 chr22:41934961 G/C cg06481639 chr22:41940642 POLR3H -0.54 -6.0 -0.31 5.22e-9 Vitiligo; CRC cis rs834811 0.829 rs834818 chr7:135895070 A/G cg01726295 chr7:135938950 NA 0.47 8.28 0.42 3.15e-15 Post-traumatic stress disorder; CRC cis rs11971779 0.618 rs3778931 chr7:139102490 A/G cg07862535 chr7:139043722 LUC7L2 0.57 7.32 0.37 1.92e-12 Diisocyanate-induced asthma; CRC cis rs72634258 0.842 rs6577463 chr1:8169485 T/G cg26816564 chr1:7831052 VAMP3 -0.53 -6.21 -0.32 1.56e-9 Inflammatory bowel disease; CRC cis rs629535 0.699 rs539956 chr8:70033647 G/A cg26132723 chr8:70041827 NA 0.35 5.72 0.3 2.41e-8 Dupuytren's disease; CRC cis rs17345786 0.861 rs79181492 chr3:101216021 G/A cg12386194 chr3:101231763 SENP7 0.51 6.37 0.33 6.36e-10 Colonoscopy-negative controls vs population controls; CRC cis rs5751150 1 rs5751150 chr22:42153292 T/G cg17554472 chr22:41940697 POLR3H 0.56 5.71 0.3 2.55e-8 Cannabis dependence symptom count; CRC cis rs4838594 0.537 rs3896665 chr10:49689413 A/G cg17291251 chr10:49678358 ARHGAP22 0.4 6.13 0.32 2.48e-9 Daytime sleep phenotypes; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg04902049 chr1:36622448 MAP7D1 0.44 6.21 0.32 1.56e-9 Response to antipsychotic treatment; CRC trans rs2840044 1.000 rs225277 chr17:33973311 G/A cg19694781 chr19:47549865 TMEM160 -0.46 -7.26 -0.37 2.77e-12 Response to radiotherapy in cancer (late toxicity); CRC cis rs3106136 0.527 rs10016806 chr4:95158495 G/T cg11021082 chr4:95130006 SMARCAD1 -0.6 -9.52 -0.46 4e-19 Capecitabine sensitivity; CRC cis rs910187 0.678 rs6018328 chr20:45813180 T/C cg27589058 chr20:45804311 EYA2 -0.39 -7.38 -0.38 1.29e-12 Migraine; CRC cis rs12368653 1.000 rs12368653 chr12:58133256 A/G cg02175503 chr12:58329896 NA 0.42 5.84 0.31 1.28e-8 Multiple sclerosis; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg08742288 chr5:141031147 FCHSD1 0.37 6.08 0.32 3.25e-9 Liver disease severity in Alagille syndrome; CRC trans rs1997103 1.000 rs4947500 chr7:55407270 C/A cg20935933 chr6:143382018 AIG1 0.51 6.65 0.34 1.25e-10 QRS interval (sulfonylurea treatment interaction); CRC trans rs2243480 1.000 rs6460261 chr7:65215580 T/C cg10756647 chr7:56101905 PSPH -0.73 -7.62 -0.39 2.71e-13 Diabetic kidney disease; CRC trans rs2948294 0.524 rs13270062 chr8:8112650 C/A cg16141378 chr3:129829833 LOC729375 -0.47 -6.17 -0.32 1.98e-9 Red cell distribution width; CRC cis rs67478160 0.643 rs12891175 chr14:104274166 T/C cg01849466 chr14:104193079 ZFYVE21 -0.46 -8.11 -0.41 1.01e-14 Schizophrenia; CRC cis rs9768139 0.524 rs7779175 chr7:158136918 C/T cg06219351 chr7:158114137 PTPRN2 0.44 6.25 0.33 1.29e-9 Calcium levels; CRC cis rs798554 0.797 rs1182174 chr7:2875420 G/A cg13628971 chr7:2884303 GNA12 0.54 7.37 0.38 1.43e-12 Height; CRC trans rs11343 0.675 rs7359333 chr16:19262344 A/T cg07919936 chr2:451875 NA -0.48 -6.17 -0.32 2e-9 Parkinson's disease; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg10573190 chr2:85843190 USP39 0.47 6.5 0.34 2.92e-10 Response to antipsychotic treatment; CRC cis rs6747952 0.899 rs12731 chr2:239087912 G/A cg17459225 chr2:239074497 NA 0.46 7.93 0.4 3.51e-14 Mean corpuscular hemoglobin concentration; CRC cis rs4481887 0.861 rs4295906 chr1:248429861 C/T cg00666640 chr1:248458726 OR2T12 0.56 10.0 0.48 9.94e-21 Common traits (Other); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg26474270 chr16:73092823 ZFHX3 0.37 6.03 0.32 4.53e-9 Liver disease severity in Alagille syndrome; CRC cis rs7618915 0.571 rs6805539 chr3:52609710 T/A cg11645453 chr3:52864694 ITIH4 0.33 5.83 0.31 1.29e-8 Bipolar disorder; CRC cis rs10464366 0.957 rs2392618 chr7:39108392 G/A cg18850127 chr7:39170497 POU6F2 0.5 6.43 0.33 4.42e-10 IgG glycosylation; CRC cis rs2404602 0.716 rs17460201 chr15:76673627 C/T cg00316803 chr15:76480434 C15orf27 0.34 5.64 0.3 3.64e-8 Blood metabolite levels; CRC cis rs644799 1.000 rs632388 chr11:95563775 A/G cg25622487 chr11:95524042 FAM76B;CEP57 0.76 11.99 0.55 9.59e-28 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs12893668 0.703 rs2274267 chr14:104029449 G/A cg08213375 chr14:104286397 PPP1R13B 0.37 5.84 0.31 1.25e-8 Reticulocyte count; CRC cis rs11711311 1.000 rs9826465 chr3:113432254 G/T cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.51 -7.03 -0.36 1.23e-11 IgG glycosylation; CRC cis rs1153858 1.000 rs10444821 chr15:45647236 C/T cg14582100 chr15:45693742 SPATA5L1 0.28 5.91 0.31 8.44e-9 Homoarginine levels; CRC cis rs9322193 0.923 rs2342765 chr6:150180009 C/G cg13206674 chr6:150067644 NUP43 0.53 7.61 0.39 2.86e-13 Lung cancer; CRC cis rs3785574 0.962 rs7219920 chr17:61811642 C/G cg23090583 chr17:61904693 PSMC5;FTSJ3 0.64 9.41 0.46 8.84e-19 Height; CRC cis rs9322193 0.923 rs9371199 chr6:150138662 A/T cg04369109 chr6:150039330 LATS1 -0.45 -5.78 -0.3 1.72e-8 Lung cancer; CRC cis rs875971 0.895 rs12531677 chr7:65769086 G/A cg00343986 chr7:65444356 GUSB -0.45 -6.25 -0.33 1.27e-9 Aortic root size; CRC cis rs7811142 1.000 rs67163493 chr7:100023838 C/T cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.99 13.56 0.6 1.37e-33 Platelet count; CRC cis rs11212617 1.000 rs10431060 chr11:108288228 A/C cg14761454 chr11:108092087 ATM;NPAT 0.41 6.12 0.32 2.61e-9 Response to metformin in type 2 diabetes (glycemic); CRC cis rs9926296 0.744 rs164749 chr16:89708224 A/C cg01097406 chr16:89675127 NA 0.47 9.22 0.45 3.59e-18 Vitiligo; CRC cis rs172166 0.694 rs1225716 chr6:28113746 A/C cg15786705 chr6:28176104 NA 0.63 9.02 0.45 1.59e-17 Cardiac Troponin-T levels; CRC cis rs7945705 0.935 rs10769971 chr11:8925276 C/T cg14711859 chr11:8959438 ASCL3 -0.5 -7.97 -0.4 2.58e-14 Hemoglobin concentration; CRC cis rs9948 0.655 rs62156212 chr2:97399096 C/T cg20312557 chr2:97357134 FER1L5 -0.6 -5.61 -0.3 4.38e-8 Erectile dysfunction and prostate cancer treatment; CRC cis rs9488822 0.596 rs13192549 chr6:116338352 C/A cg18764771 chr6:116381957 FRK 0.23 6.36 0.33 6.76e-10 Cholesterol, total;LDL cholesterol; CRC cis rs17253792 0.822 rs80174205 chr14:56058694 T/C cg01858014 chr14:56050164 KTN1 -0.85 -6.72 -0.35 7.81e-11 Putamen volume; CRC cis rs11123170 0.542 rs28522253 chr2:113967387 G/A cg21482265 chr2:113992762 PAX8;LOC440839;LOC654433 0.52 6.13 0.32 2.53e-9 Renal function-related traits (BUN); CRC cis rs6951245 1.000 rs80031817 chr7:1096793 T/C cg21664854 chr7:1097933 C7orf50;GPR146 0.78 8.81 0.44 7.57e-17 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC trans rs1814175 0.904 rs7924371 chr11:49620595 C/T cg11707556 chr5:10655725 ANKRD33B -0.43 -8.08 -0.41 1.29e-14 Height; CRC cis rs875971 0.545 rs17138149 chr7:65693180 A/G cg05627663 chr7:65219948 SNORA22;CCT6P1 0.58 7.53 0.38 5e-13 Aortic root size; CRC cis rs71444571 1 rs71444571 chr12:123771015 G/A cg00376283 chr12:123451042 ABCB9 -0.54 -6.15 -0.32 2.2e-9 Lymphocyte percentage of white cells; CRC trans rs1555895 0.611 rs2892159 chr10:855061 G/A cg16899823 chr10:58121153 ZWINT -0.39 -6.03 -0.32 4.38e-9 Survival in rectal cancer; CRC cis rs10256972 0.621 rs2280725 chr7:1087426 G/T cg18765753 chr7:1198926 ZFAND2A -0.32 -5.7 -0.3 2.68e-8 Longevity;Endometriosis; CRC cis rs1348850 0.651 rs4893821 chr2:178229352 A/G cg02961200 chr2:178257176 LOC100130691;AGPS -0.49 -6.96 -0.36 1.81e-11 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs6570726 0.791 rs12205752 chr6:145896118 A/G cg05347473 chr6:146136440 FBXO30 0.38 5.85 0.31 1.18e-8 Lobe attachment (rater-scored or self-reported); CRC cis rs11030122 0.702 rs17279635 chr11:3973083 A/C cg18678763 chr11:4115507 RRM1 0.49 8.23 0.41 4.44e-15 Mean platelet volume;Platelet distribution width; CRC cis rs4665809 1.000 rs2891490 chr2:26325927 T/C cg26119090 chr2:26468346 HADHA;HADHB -0.62 -7.92 -0.4 3.73e-14 Gut microbiome composition (summer); CRC cis rs9527 0.615 rs7080462 chr10:104736699 T/C cg04362960 chr10:104952993 NT5C2 0.6 8.49 0.42 7.09e-16 Arsenic metabolism; CRC cis rs1348850 0.914 rs12104588 chr2:178253675 G/A cg02961200 chr2:178257176 LOC100130691;AGPS 0.61 9.17 0.45 5.25e-18 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs6545883 0.929 rs778140 chr2:61682976 C/T cg15711740 chr2:61764176 XPO1 -0.43 -5.62 -0.3 4.05e-8 Tuberculosis; CRC cis rs2204008 0.744 rs11495519 chr12:38060546 C/A cg13010199 chr12:38710504 ALG10B 0.44 5.64 0.3 3.74e-8 Bladder cancer; CRC cis rs78456975 0.600 rs72776256 chr2:1529595 C/A cg01028140 chr2:1542097 TPO -0.58 -5.89 -0.31 9.55e-9 Placebo response in major depressive disorder (% change in symptom score); CRC cis rs9443645 0.810 rs9443637 chr6:79714708 C/T cg09184832 chr6:79620586 NA -0.47 -8.46 -0.42 8.66e-16 Intelligence (multi-trait analysis); CRC cis rs2281845 0.533 rs112365857 chr1:201097222 G/C cg08885800 chr1:201084119 NA 0.42 5.87 0.31 1.06e-8 Permanent tooth development; CRC cis rs6089584 0.888 rs2146853 chr20:60617908 A/T cg23262073 chr20:60523788 NA -0.46 -7.24 -0.37 3.25e-12 Body mass index; CRC cis rs6120849 0.663 rs13041792 chr20:33545055 G/A cg08999081 chr20:33150536 PIGU 0.43 5.68 0.3 3e-8 Protein C levels; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg16672449 chr3:127842622 RUVBL1 0.49 6.33 0.33 7.8e-10 Thyroid stimulating hormone; CRC cis rs10971721 0.730 rs72725361 chr9:33806613 C/T cg13495928 chr9:33750294 PRSS3 0.56 5.85 0.31 1.16e-8 Body mass index; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg11122148 chr13:45150705 TSC22D1 -0.4 -6.79 -0.35 5.29e-11 Myopia (pathological); CRC cis rs8014204 0.604 rs11625594 chr14:75389833 G/A cg06998765 chr14:75389618 RPS6KL1 -0.26 -6.36 -0.33 6.74e-10 Caffeine consumption; CRC cis rs1799949 1.000 rs33918839 chr17:41329172 T/C cg05368731 chr17:41323189 NBR1 0.69 10.45 0.5 2.95e-22 Menopause (age at onset); CRC trans rs12599106 0.560 rs34151874 chr16:34989694 G/A cg20062050 chr1:227730881 NA 0.36 6.09 0.32 3.18e-9 Menopause (age at onset); CRC cis rs4481887 0.646 rs28421649 chr1:248548122 G/C cg00666640 chr1:248458726 OR2T12 0.33 6.29 0.33 9.92e-10 Common traits (Other); CRC cis rs10512697 0.803 rs13190123 chr5:3578348 G/A cg19473799 chr5:3511975 NA -0.73 -5.8 -0.3 1.53e-8 Immune response to smallpox vaccine (IL-6); CRC cis rs4474465 0.646 rs7936011 chr11:78275931 G/T cg27205649 chr11:78285834 NARS2 0.52 6.92 0.36 2.3e-11 Alzheimer's disease (survival time); CRC trans rs9784649 0.641 rs72755823 chr5:25075537 T/C cg08600765 chr20:34638493 LOC647979 -0.76 -9.28 -0.46 2.4e-18 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs9868809 0.505 rs9811027 chr3:48725014 G/C cg00383909 chr3:49044727 WDR6 0.78 7.97 0.4 2.56e-14 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; CRC cis rs2880765 0.835 rs7168860 chr15:86037030 G/A cg17133734 chr15:86042851 AKAP13 0.42 6.63 0.34 1.36e-10 Coronary artery disease; CRC trans rs5756813 0.727 rs4821703 chr22:38136676 C/T cg19894588 chr14:64061835 NA -0.61 -8.19 -0.41 5.88e-15 Optic cup area;Vertical cup-disc ratio; CRC cis rs1843834 0.858 rs12105685 chr2:225513164 A/G cg22455342 chr2:225449267 CUL3 0.48 6.43 0.33 4.38e-10 IgE levels in asthmatics (D.p. specific); CRC cis rs61160187 0.548 rs17392014 chr5:60165200 G/A cg16298547 chr5:60138761 ELOVL7 -0.29 -6.02 -0.32 4.6e-9 Educational attainment (years of education);Educational attainment (college completion); CRC cis rs2075165 0.836 rs7512751 chr1:156234439 T/G cg20302342 chr1:156215951 PAQR6 0.41 8.18 0.41 6.26e-15 Tonsillectomy; CRC cis rs270601 0.913 rs273916 chr5:131659830 C/A cg18301423 chr5:131593218 PDLIM4 0.38 6.32 0.33 8.74e-10 Acylcarnitine levels; CRC cis rs34375054 0.752 rs12582808 chr12:125661459 G/T cg06287003 chr12:125626642 AACS -0.63 -7.94 -0.4 3.26e-14 Post bronchodilator FEV1/FVC ratio; CRC cis rs4713118 0.513 rs149942 chr6:28001610 T/C cg03623178 chr6:28175578 NA 0.75 11.28 0.53 3.55e-25 Parkinson's disease; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg20420867 chr1:160175396 PEA15 0.41 6.04 0.32 4.06e-9 Intelligence (multi-trait analysis); CRC cis rs9733 0.569 rs11204691 chr1:150644339 A/T cg17724175 chr1:150552817 MCL1 0.58 9.4 0.46 9.25e-19 Tonsillectomy; CRC cis rs929354 0.553 rs34498858 chr7:156931337 T/C cg05182265 chr7:156933206 UBE3C -0.75 -14.17 -0.62 6.57e-36 Body mass index; CRC cis rs8060686 0.641 rs1125333 chr16:68227566 C/A cg08314208 chr16:67682810 RLTPR -0.54 -5.94 -0.31 7.18e-9 HDL cholesterol;Metabolic syndrome; CRC cis rs6570726 0.935 rs366308 chr6:145814532 T/A cg23711669 chr6:146136114 FBXO30 0.68 12.05 0.55 6.18e-28 Lobe attachment (rater-scored or self-reported); CRC cis rs2882667 0.861 rs13176902 chr5:138393329 T/C cg04439458 chr5:138467593 SIL1 -0.33 -6.12 -0.32 2.63e-9 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs3617 0.539 rs11922975 chr3:52936763 C/T cg18099408 chr3:52552593 STAB1 0.35 5.88 0.31 9.97e-9 Red blood cell count;Autism spectrum disorder or schizophrenia; CRC cis rs9527 0.590 rs7917650 chr10:104937100 G/C cg04362960 chr10:104952993 NT5C2 0.61 8.44 0.42 1.03e-15 Arsenic metabolism; CRC cis rs7267979 0.789 rs4815429 chr20:25521611 T/C cg24626310 chr20:25276739 ABHD12;PYGB -0.33 -5.7 -0.3 2.61e-8 Liver enzyme levels (alkaline phosphatase); CRC cis rs6674176 0.628 rs7556565 chr1:44416090 C/T cg15962314 chr1:44399869 ARTN 0.3 5.76 0.3 1.9e-8 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Cognitive ability; CRC cis rs2479724 0.846 rs1536702 chr6:41869950 T/A cg17623882 chr6:41773611 USP49 -0.54 -8.9 -0.44 3.86e-17 Menarche (age at onset); CRC cis rs7927592 0.763 rs7120876 chr11:68261398 C/G cg16797656 chr11:68205561 LRP5 0.5 9.29 0.46 2.19e-18 Total body bone mineral density; CRC cis rs35110281 0.811 rs1122873 chr21:45044672 G/C cg01579765 chr21:45077557 HSF2BP -0.39 -7.66 -0.39 2.06e-13 Mean corpuscular volume; CRC cis rs9427116 0.840 rs9427113 chr1:154626477 A/G cg17218026 chr1:154582156 ADAR 0.57 9.24 0.45 3.11e-18 Blood protein levels; CRC cis rs12928939 0.517 rs71384782 chr16:71978591 A/G cg03805757 chr16:71968109 PKD1L3 -0.6 -7.97 -0.4 2.67e-14 Post bronchodilator FEV1; CRC cis rs2281845 0.507 rs7547762 chr1:201088245 A/G cg24849736 chr1:201084428 NA 0.47 6.46 0.34 3.81e-10 Permanent tooth development; CRC cis rs7772486 0.727 rs10447449 chr6:146138707 A/G cg23711669 chr6:146136114 FBXO30 0.69 11.66 0.54 1.53e-26 Lobe attachment (rater-scored or self-reported); CRC cis rs2180341 0.694 rs2875972 chr6:127585522 T/C cg24812749 chr6:127587940 RNF146 0.78 11.25 0.53 4.48e-25 Breast cancer; CRC cis rs12464483 0.591 rs4952171 chr2:30886903 G/A cg12454169 chr2:30669597 LCLAT1 0.64 6.92 0.36 2.4e-11 Pre-treatment pain in head and neck squamous cell carcinoma; CRC cis rs561341 0.941 rs17780080 chr17:30343146 G/A cg23018236 chr17:30244563 NA -0.68 -8.1 -0.41 1.12e-14 Hip circumference adjusted for BMI; CRC cis rs2289681 0.525 rs34637106 chr17:42985772 C/T cg15193461 chr17:42977049 CCDC103;EFTUD2 -0.5 -6.18 -0.32 1.89e-9 Cognitive function; CRC cis rs9649213 0.593 rs6973775 chr7:98004685 G/A cg00277769 chr7:97922759 BAIAP2L1 -0.6 -10.38 -0.5 5.03e-22 Prostate cancer (SNP x SNP interaction); CRC cis rs921968 0.643 rs537520 chr2:219381852 A/G cg02176678 chr2:219576539 TTLL4 0.48 7.97 0.4 2.72e-14 Mean corpuscular hemoglobin concentration; CRC cis rs2652834 0.904 rs2937859 chr15:63366282 C/T cg05507819 chr15:63340323 TPM1 0.48 6.51 0.34 2.82e-10 HDL cholesterol; CRC cis rs10504229 0.728 rs72650868 chr8:58155568 G/C cg21724239 chr8:58056113 NA 0.62 8.38 0.42 1.51e-15 Developmental language disorder (linguistic errors); CRC cis rs79387448 0.638 rs6759588 chr2:103040159 A/G cg09003973 chr2:102972529 NA 0.97 9.77 0.47 5.9e-20 Gut microbiota (bacterial taxa); CRC cis rs76793172 0.623 rs8107744 chr19:46300848 C/A cg11657440 chr19:46296263 DMWD 0.58 5.93 0.31 7.81e-9 Eosinophil counts; CRC cis rs17253792 0.598 rs71413578 chr14:56018651 T/C cg01858014 chr14:56050164 KTN1 -0.86 -6.64 -0.34 1.27e-10 Putamen volume; CRC cis rs1570884 0.516 rs7330830 chr13:50167929 T/A cg03651054 chr13:50194643 NA 0.34 6.87 0.35 3.2e-11 Sum basophil neutrophil counts;Sum neutrophil eosinophil counts;Neutrophil count;Myeloid white cell count;Granulocyte count; CRC cis rs9467711 0.606 rs72836482 chr6:26359241 A/T cg14345882 chr6:26364793 BTN3A2 0.64 5.63 0.3 3.85e-8 Autism spectrum disorder or schizophrenia; CRC cis rs10504229 0.683 rs7000349 chr8:58114569 C/A cg05313129 chr8:58192883 C8orf71 -0.43 -6.0 -0.31 5.07e-9 Developmental language disorder (linguistic errors); CRC cis rs236352 0.576 rs3756905 chr6:36843777 C/T cg10099585 chr6:36853529 C6orf89 -0.46 -6.47 -0.34 3.6e-10 Heart rate; CRC cis rs7412746 0.658 rs12410394 chr1:150860186 G/A cg17724175 chr1:150552817 MCL1 0.47 7.08 0.36 8.64e-12 Melanoma; CRC cis rs6968419 0.747 rs6959237 chr7:115876365 C/T cg02561103 chr7:115862891 TES -0.42 -6.31 -0.33 8.85e-10 Intraocular pressure; CRC cis rs6952808 0.594 rs3778964 chr7:2138109 C/T cg02951883 chr7:2050386 MAD1L1 -0.67 -10.49 -0.5 2.16e-22 Bipolar disorder and schizophrenia; CRC cis rs9393692 0.905 rs1125000 chr6:26287256 C/T cg13736514 chr6:26305472 NA -0.62 -11.44 -0.53 9.41e-26 Educational attainment; CRC cis rs7131987 0.650 rs11050188 chr12:29473108 A/C cg09582351 chr12:29534625 ERGIC2 -0.34 -7.19 -0.37 4.36e-12 QT interval; CRC cis rs16924133 0.793 rs68188425 chr11:33196919 A/G cg05567920 chr11:33183001 CSTF3 -0.78 -6.09 -0.32 3.22e-9 Anger; CRC cis rs4908768 0.501 rs6577499 chr1:8612104 C/G cg20416874 chr1:8611966 RERE 0.43 6.08 0.32 3.38e-9 Neuroticism (multi-trait analysis);Subjective well-being (multi-trait analysis); CRC cis rs2933343 0.700 rs1683777 chr3:128624880 T/G cg11901034 chr3:128598214 ACAD9 -0.56 -8.11 -0.41 1.01e-14 IgG glycosylation; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg01778450 chr5:92920498 NR2F1 0.41 6.7 0.35 9.15e-11 Liver disease severity in Alagille syndrome; CRC trans rs7937682 0.921 rs4534611 chr11:111440425 C/G cg18187862 chr3:45730750 SACM1L 0.44 6.06 0.32 3.64e-9 Primary sclerosing cholangitis; CRC cis rs4700695 0.719 rs27078 chr5:65445331 G/C cg21114390 chr5:65439923 SFRS12 -0.63 -8.49 -0.42 6.96e-16 Facial morphology (factor 19); CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg21939482 chr7:6388130 C7orf70 -0.56 -6.94 -0.36 2.15e-11 Diisocyanate-induced asthma; CRC cis rs875971 0.862 rs2420611 chr7:65999320 A/G cg11764359 chr7:65958608 NA 0.59 8.86 0.44 5.17e-17 Aortic root size; CRC cis rs13082711 0.595 rs62255583 chr3:27309704 G/T cg02860705 chr3:27208620 NA 0.84 11.24 0.53 5.23e-25 Systolic blood pressure;Diastolic blood pressure;Blood pressure; CRC cis rs1552244 0.882 rs13084194 chr3:10031492 T/A cg10729496 chr3:10149963 C3orf24 0.52 6.41 0.33 5.07e-10 Alzheimer's disease; CRC cis rs453301 0.686 rs3895823 chr8:8873646 T/C cg14979609 chr8:8086686 FLJ10661 0.37 6.04 0.32 4.13e-9 Joint mobility (Beighton score); CRC cis rs9487051 1.000 rs1008084 chr6:109626965 G/A cg21918786 chr6:109611834 NA -0.38 -6.46 -0.34 3.84e-10 Reticulocyte fraction of red cells; CRC cis rs9611565 0.512 rs4822052 chr22:42193741 G/A cg06481639 chr22:41940642 POLR3H -0.5 -5.79 -0.3 1.62e-8 Vitiligo; CRC cis rs6963495 0.556 rs711433 chr7:105153191 A/G cg02135003 chr7:105160482 PUS7 0.51 8.03 0.4 1.7e-14 Bipolar disorder (body mass index interaction); CRC cis rs155076 0.666 rs9509640 chr13:21872880 T/C cg25811766 chr13:21894605 NA 0.66 7.65 0.39 2.29e-13 White matter hyperintensity burden; CRC cis rs10504229 0.815 rs72650879 chr8:58164648 A/G cg24829409 chr8:58192753 C8orf71 -0.62 -8.25 -0.41 3.81e-15 Developmental language disorder (linguistic errors); CRC cis rs9303401 0.632 rs9915267 chr17:57244907 A/G cg10487724 chr17:56770010 TEX14;RAD51C 0.42 6.41 0.33 5e-10 Cognitive test performance; CRC cis rs7465272 1.000 rs35900184 chr8:143693411 C/T cg19438565 chr8:143695827 ARC -0.44 -6.08 -0.32 3.35e-9 Bipolar disorder and schizophrenia; CRC cis rs7394190 0.748 rs2292307 chr10:75549916 C/A cg07699608 chr10:75541558 CHCHD1 0.7 6.92 0.36 2.37e-11 Incident atrial fibrillation; CRC cis rs523522 0.962 rs11065149 chr12:120956963 G/A cg12219531 chr12:120966889 COQ5 0.69 9.28 0.46 2.36e-18 High light scatter reticulocyte count; CRC trans rs11264213 0.711 rs10752603 chr1:36161576 C/A cg07175433 chr4:21947400 KCNIP4 0.37 6.36 0.33 6.71e-10 Schizophrenia; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg08694802 chr16:15149554 NTAN1 0.45 6.04 0.32 4.27e-9 Thyroid stimulating hormone; CRC trans rs1814175 0.817 rs10839465 chr11:49981554 C/A cg15704280 chr7:45808275 SEPT13 -1.02 -20.61 -0.75 3.5e-61 Height; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg19721801 chr19:12807424 FBXW9 0.45 6.23 0.32 1.4e-9 Anxiety disorder; CRC trans rs61883261 0.764 rs11025864 chr11:21008423 A/G cg13263472 chr14:102593156 HSP90AA1 -0.63 -6.24 -0.33 1.32e-9 Response to amphetamines; CRC cis rs1403694 0.695 rs5029969 chr3:186434405 G/T cg04611788 chr3:186434169 KNG1 -0.61 -9.13 -0.45 7.33e-18 Blood protein levels; CRC cis rs548181 0.609 rs511822 chr11:125534115 C/T cg03464685 chr11:125439445 EI24 1.18 12.42 0.56 2.63e-29 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs4148883 0.651 rs2851301 chr4:100010127 C/T cg13256891 chr4:100009986 ADH5 0.46 6.44 0.33 4.12e-10 Alcohol dependence; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg22834172 chr17:37774349 NA 0.44 6.15 0.32 2.22e-9 Response to antipsychotic treatment; CRC cis rs4665809 0.590 rs4665319 chr2:26424583 A/C cg08067268 chr2:26466485 HADHB;HADHA -0.49 -6.36 -0.33 6.59e-10 Gut microbiome composition (summer); CRC trans rs10983614 1.000 rs7867776 chr9:120072627 A/G cg08045063 chr3:43147672 C3orf39 0.47 6.33 0.33 7.97e-10 Survival in pancreatic cancer; CRC cis rs6460942 0.915 rs7803056 chr7:12306913 A/C cg06484146 chr7:12443880 VWDE -0.56 -7.22 -0.37 3.67e-12 Coronary artery disease; CRC cis rs6502050 0.835 rs4789670 chr17:80151805 T/C cg22110888 chr17:80059540 CCDC57 0.39 6.25 0.33 1.29e-9 Life satisfaction; CRC cis rs4975616 0.710 rs27996 chr5:1345474 A/G cg06550200 chr5:1325588 CLPTM1L -0.71 -11.22 -0.53 5.79e-25 Lung cancer; CRC cis rs10979 1.000 rs9484767 chr6:143887912 C/A cg25407410 chr6:143891975 LOC285740 -0.82 -13.41 -0.59 5.06e-33 Hypospadias; CRC cis rs55823223 0.590 rs11870142 chr17:73859002 A/G cg24416660 chr17:73865998 NA -0.4 -6.08 -0.32 3.34e-9 Psoriasis; CRC cis rs7666738 0.791 rs7657399 chr4:98851861 T/C cg17366294 chr4:99064904 C4orf37 0.4 6.48 0.34 3.45e-10 Colonoscopy-negative controls vs population controls; CRC cis rs1552172 0.887 rs12729321 chr1:145645820 G/T cg11743829 chr1:145714124 CD160 -0.4 -6.09 -0.32 3.23e-9 Breast cancer; CRC trans rs11250098 0.574 rs4240672 chr8:10767917 G/A cg06636001 chr8:8085503 FLJ10661 -0.5 -7.52 -0.38 5.38e-13 Morning vs. evening chronotype; CRC cis rs1448094 0.549 rs7297996 chr12:86235899 C/T cg02569458 chr12:86230093 RASSF9 0.45 7.68 0.39 1.84e-13 Major depressive disorder; CRC cis rs2067615 0.542 rs11113120 chr12:107203460 T/C cg13491945 chr12:107078410 RFX4 0.37 6.29 0.33 1.03e-9 Heart rate; CRC cis rs4665809 0.590 rs1469523 chr2:26474631 T/A cg08067268 chr2:26466485 HADHB;HADHA 0.66 8.38 0.42 1.54e-15 Gut microbiome composition (summer); CRC cis rs6496667 0.683 rs1869180 chr15:90895467 T/C cg22089800 chr15:90895588 ZNF774 0.4 5.77 0.3 1.82e-8 Rheumatoid arthritis; CRC cis rs6952808 0.723 rs1107592 chr7:2041432 C/T cg02951883 chr7:2050386 MAD1L1 0.71 11.86 0.55 2.87e-27 Bipolar disorder and schizophrenia; CRC cis rs4423214 1.000 rs4944062 chr11:71187294 G/T cg05163923 chr11:71159392 DHCR7 0.66 9.35 0.46 1.42e-18 Vitamin D levels; CRC cis rs12477438 0.520 rs11890338 chr2:99767868 C/T cg26064155 chr2:99771622 LIPT1;TSGA10 0.88 16.2 0.67 8.61e-44 Chronic sinus infection; CRC cis rs2019137 0.936 rs12620738 chr2:113963739 C/T cg21610815 chr2:113994035 PAX8;LOC654433;LOC440839 -0.46 -6.53 -0.34 2.53e-10 Lymphocyte counts; CRC cis rs7107174 1.000 rs7127187 chr11:77995188 G/A cg02023728 chr11:77925099 USP35 0.53 8.09 0.41 1.15e-14 Testicular germ cell tumor; CRC cis rs3733585 0.699 rs6852441 chr4:9973744 C/T cg11266682 chr4:10021025 SLC2A9 -0.46 -9.33 -0.46 1.66e-18 Cleft plate (environmental tobacco smoke interaction); CRC cis rs274567 0.501 rs272855 chr5:131687175 C/T cg02033258 chr5:131593261 PDLIM4 0.39 6.41 0.33 5.13e-10 Blood metabolite levels; CRC trans rs9329221 0.537 rs13254175 chr8:9978772 C/T cg06636001 chr8:8085503 FLJ10661 0.46 6.87 0.35 3.14e-11 Neuroticism; CRC cis rs561341 0.882 rs2428337 chr17:30299467 C/T cg00745463 chr17:30367425 LRRC37B -0.9 -9.9 -0.48 2.09e-20 Hip circumference adjusted for BMI; CRC cis rs10504229 0.683 rs72649187 chr8:58108320 A/G cg21724239 chr8:58056113 NA 0.52 6.97 0.36 1.79e-11 Developmental language disorder (linguistic errors); CRC cis rs860295 0.702 rs12041534 chr1:155407096 A/G cg02153340 chr1:155202674 NA 0.5 6.48 0.34 3.39e-10 Body mass index; CRC cis rs3540 0.960 rs2238327 chr15:91012949 G/A cg22089800 chr15:90895588 ZNF774 0.49 7.91 0.4 4.07e-14 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; CRC cis rs1348850 0.567 rs1405714 chr2:178538584 A/G cg22681709 chr2:178499509 PDE11A 0.46 8.42 0.42 1.18e-15 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs9549328 0.544 rs66893681 chr13:113617499 A/G cg08614441 chr13:113633676 MCF2L 0.4 7.06 0.36 9.78e-12 Systolic blood pressure; CRC trans rs11098499 0.863 rs3775849 chr4:120450908 G/C cg25214090 chr10:38739885 LOC399744 0.65 10.07 0.49 5.96e-21 Corneal astigmatism; CRC cis rs10927875 0.541 rs1739840 chr1:16342237 A/G cg22431228 chr1:16359049 CLCNKA -0.37 -6.72 -0.35 8.23e-11 Dilated cardiomyopathy; CRC cis rs9419702 0.614 rs9419567 chr10:133535149 C/G cg04492858 chr10:133558786 NA 0.35 5.62 0.3 4.12e-8 Survival in rectal cancer; CRC cis rs270601 0.770 rs4361510 chr5:131599647 C/T cg04518342 chr5:131593106 PDLIM4 0.52 9.66 0.47 1.37e-19 Acylcarnitine levels; CRC cis rs4862750 0.915 rs6835681 chr4:187903476 A/G cg11301795 chr4:187892539 NA -0.85 -18.45 -0.71 1.13e-52 Lobe attachment (rater-scored or self-reported); CRC trans rs7726839 0.540 rs72703092 chr5:599269 G/A cg25482853 chr8:67687455 SGK3 1.1 12.97 0.58 2.42e-31 Obesity-related traits; CRC cis rs6693567 0.565 rs834234 chr1:150352494 C/G cg15654264 chr1:150340011 RPRD2 -0.37 -5.79 -0.3 1.67e-8 Migraine; CRC cis rs7811142 0.775 rs1059129 chr7:99926522 A/G cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.7 9.7 0.47 9.74e-20 Platelet count; CRC cis rs5769765 0.773 rs11090920 chr22:50320105 A/G cg08270630 chr22:50330655 NA -0.43 -5.77 -0.3 1.87e-8 Schizophrenia; CRC cis rs9487051 0.872 rs9400269 chr6:109606065 C/G cg21918786 chr6:109611834 NA -0.45 -8.31 -0.42 2.54e-15 Reticulocyte fraction of red cells; CRC cis rs4509693 0.782 rs12268880 chr10:102495285 G/C cg23167259 chr10:102495509 NA -0.47 -5.87 -0.31 1.06e-8 Alzheimer's disease; CRC cis rs6860806 0.507 rs582490 chr5:131710095 G/A cg04518342 chr5:131593106 PDLIM4 -0.43 -7.01 -0.36 1.39e-11 Breast cancer; CRC cis rs4713118 0.513 rs156734 chr6:28007357 A/C cg25164649 chr6:28176230 NA 0.61 8.92 0.44 3.4e-17 Parkinson's disease; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg01246254 chr10:124134882 PLEKHA1 0.54 8.91 0.44 3.6e-17 Liver disease severity in Alagille syndrome; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg22312910 chr11:65082369 CDC42EP2 0.47 6.63 0.34 1.37e-10 Anxiety disorder; CRC trans rs6601327 0.641 rs12542457 chr8:9564600 A/G cg06636001 chr8:8085503 FLJ10661 -0.47 -6.81 -0.35 4.51e-11 Multiple myeloma (hyperdiploidy); CRC cis rs75920871 0.528 rs2513094 chr11:116806412 T/C cg20608306 chr11:116969690 SIK3 -0.34 -6.34 -0.33 7.68e-10 Subjective well-being; CRC cis rs208346 0.612 rs208356 chr7:2775825 A/T cg09658497 chr7:2847517 GNA12 0.37 6.03 0.32 4.43e-9 Loneliness (linear analysis); CRC cis rs10413329 0.782 rs10408457 chr19:13101196 T/G cg13338734 chr19:13113668 NFIX 0.33 5.66 0.3 3.23e-8 Intelligence (multi-trait analysis); CRC cis rs9322193 0.923 rs2151913 chr6:150130642 C/T cg05861140 chr6:150128134 PCMT1 -0.41 -6.55 -0.34 2.28e-10 Lung cancer; CRC cis rs3091242 1.000 rs9689 chr1:25688276 A/G cg27572855 chr1:25598939 RHD 0.33 6.03 0.32 4.52e-9 Erythrocyte sedimentation rate; CRC trans rs11098499 0.866 rs9991221 chr4:120292107 G/C cg25214090 chr10:38739885 LOC399744 0.61 9.66 0.47 1.39e-19 Corneal astigmatism; CRC cis rs3806843 1.000 rs3756340 chr5:140180451 T/G cg16607685 chr5:140181889 PCDHA2;PCDHA1;PCDHA3 -0.27 -6.27 -0.33 1.13e-9 Depressive symptoms (multi-trait analysis); CRC cis rs12134245 0.747 rs35654098 chr1:92001452 T/A cg25838465 chr1:92012736 NA -0.68 -12.62 -0.57 4.58e-30 Breast cancer; CRC cis rs2249694 0.878 rs2480256 chr10:135352514 A/G cg20169779 chr10:135381914 SYCE1 0.54 8.63 0.43 2.6e-16 Obesity-related traits; CRC cis rs10193935 0.901 rs6724626 chr2:42689757 C/G cg27598129 chr2:42591480 NA 0.67 7.88 0.4 4.72e-14 Colonoscopy-negative controls vs population controls; CRC cis rs10504229 0.775 rs17805146 chr8:58161484 G/A cg20607798 chr8:58055168 NA 0.47 5.78 0.3 1.76e-8 Developmental language disorder (linguistic errors); CRC cis rs1881797 1.000 rs10925069 chr1:247681313 C/T cg11166453 chr1:247681781 NA -0.49 -8.84 -0.44 5.9e-17 Acute lymphoblastic leukemia (childhood); CRC cis rs9868809 0.881 rs2276852 chr3:48666923 A/G cg07636037 chr3:49044803 WDR6 -0.63 -6.76 -0.35 6.2e-11 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; CRC cis rs9733 0.628 rs11807409 chr1:150683423 C/T cg17724175 chr1:150552817 MCL1 0.57 9.1 0.45 9.14e-18 Tonsillectomy; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg16025468 chr1:119682959 WARS2 0.36 5.97 0.31 6.27e-9 Liver disease severity in Alagille syndrome; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg17994379 chr17:43025264 KIF18B 0.44 6.55 0.34 2.27e-10 Response to antipsychotic treatment; CRC cis rs9733 0.570 rs951281 chr1:150691122 A/C cg10589385 chr1:150898437 SETDB1 0.28 5.96 0.31 6.66e-9 Tonsillectomy; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg13897145 chr3:113557582 GRAMD1C 0.5 6.62 0.34 1.44e-10 Thyroid stimulating hormone; CRC cis rs231513 0.954 rs231514 chr17:41964516 C/T cg26893861 chr17:41843967 DUSP3 -0.7 -6.44 -0.33 4.34e-10 Cognitive function; CRC cis rs12545109 0.842 rs2609975 chr8:57401667 T/C cg09654669 chr8:57350985 NA -0.39 -5.71 -0.3 2.54e-8 Obesity-related traits; CRC cis rs9611565 0.512 rs4512 chr22:42206084 G/C cg06481639 chr22:41940642 POLR3H -0.56 -6.17 -0.32 1.97e-9 Vitiligo; CRC cis rs4730250 0.707 rs257385 chr7:106807448 T/C cg02696742 chr7:106810147 HBP1 -0.65 -6.93 -0.36 2.28e-11 Osteoarthritis; CRC cis rs12431939 0.571 rs12589840 chr14:51720038 A/G cg23942311 chr14:51606299 NA 0.53 6.93 0.36 2.27e-11 Cancer; CRC cis rs853679 0.517 rs9368557 chr6:28131537 T/C cg15786705 chr6:28176104 NA 0.78 9.83 0.48 3.57e-20 Depression; CRC cis rs17345786 1.000 rs55641278 chr3:101290577 G/A cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.56 6.58 0.34 1.82e-10 Colonoscopy-negative controls vs population controls; CRC cis rs853679 0.517 rs4711165 chr6:28115184 T/G cg12273811 chr6:28175739 NA 0.73 9.16 0.45 5.8e-18 Depression; CRC cis rs477895 0.653 rs11231701 chr11:63893702 G/A cg23719950 chr11:63933701 MACROD1 -0.65 -8.23 -0.41 4.31e-15 Mean platelet volume; CRC cis rs6546324 1.000 rs2902026 chr2:67856440 G/C cg15745817 chr2:67799979 NA -0.29 -5.76 -0.3 1.96e-8 Endometriosis; CRC trans rs7647973 0.626 rs2131108 chr3:49665390 C/T cg21659725 chr3:3221576 CRBN -0.67 -7.43 -0.38 9.42e-13 Menarche (age at onset); CRC cis rs9381040 0.655 rs7738684 chr6:41038552 G/A cg04346459 chr6:41068666 NFYA;LOC221442 -0.42 -6.22 -0.32 1.49e-9 Alzheimer's disease (late onset); CRC cis rs853679 1.000 rs853676 chr6:28299687 C/T cg06470822 chr6:28175283 NA 0.65 6.56 0.34 2.04e-10 Depression; CRC cis rs875971 0.522 rs6960048 chr7:65408039 A/G cg05627663 chr7:65219948 SNORA22;CCT6P1 0.49 7.33 0.37 1.76e-12 Aortic root size; CRC cis rs17401966 0.867 rs7546364 chr1:10418815 G/A cg19773385 chr1:10388646 KIF1B -0.66 -10.72 -0.51 3.52e-23 Hepatocellular carcinoma; CRC cis rs9902453 1.000 rs9896062 chr17:28357047 G/A cg26525008 chr17:28256777 EFCAB5;SSH2 -0.59 -8.86 -0.44 4.95e-17 Coffee consumption (cups per day); CRC cis rs2985684 1.000 rs3007030 chr14:50086563 C/T cg04989706 chr14:50066350 PPIL5 -0.59 -8.07 -0.41 1.35e-14 Carotid intima media thickness; CRC cis rs1443512 0.704 rs4759308 chr12:54329031 A/T cg17410650 chr12:54324560 NA -0.37 -6.7 -0.35 8.79e-11 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for BMI in non-smokers;Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction);Waist-hip ratio;Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour); CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg09961100 chr19:5978428 RANBP3 0.46 6.42 0.33 4.88e-10 Anxiety disorder; CRC cis rs7726839 0.507 rs56282020 chr5:596701 T/C cg17948913 chr5:572064 NA 0.5 5.79 0.3 1.61e-8 Obesity-related traits; CRC cis rs7666738 0.830 rs28810677 chr4:99043193 C/T cg17366294 chr4:99064904 C4orf37 0.45 7.73 0.39 1.34e-13 Colonoscopy-negative controls vs population controls; CRC cis rs11948739 0.501 rs4254896 chr5:130363499 C/T cg08523029 chr5:130500466 HINT1 -0.45 -5.96 -0.31 6.37e-9 Pediatric bone mineral content (hip); CRC cis rs10504229 1.000 rs57624567 chr8:58176995 T/C cg05313129 chr8:58192883 C8orf71 -0.47 -6.99 -0.36 1.49e-11 Developmental language disorder (linguistic errors); CRC cis rs7412746 0.552 rs4970980 chr1:150864992 A/C cg17724175 chr1:150552817 MCL1 0.39 6.0 0.31 5.11e-9 Melanoma; CRC cis rs7737355 0.947 rs244733 chr5:130822778 T/C cg06307176 chr5:131281290 NA 0.41 6.1 0.32 2.96e-9 Life satisfaction; CRC cis rs1401999 1.000 rs3805108 chr3:183691650 T/C cg20387954 chr3:183756860 HTR3D 0.42 7.17 0.37 5.04e-12 Anterior chamber depth; CRC cis rs910316 0.687 rs11627442 chr14:75669649 A/G cg11812906 chr14:75593930 NEK9 -0.48 -6.99 -0.36 1.5e-11 Height; CRC trans rs2014572 0.967 rs10412975 chr19:57770554 C/A cg02674126 chr19:40336878 FBL 0.41 6.52 0.34 2.6200000000000003e-10 Hyperactive-impulsive symptoms; CRC cis rs910316 1.000 rs4903275 chr14:75512509 C/T cg11812906 chr14:75593930 NEK9 0.63 10.0 0.48 9.8e-21 Height; CRC cis rs9787249 1.000 rs9787249 chr1:40212878 G/A cg19912559 chr1:40204330 PPIE 0.52 7.7 0.39 1.65e-13 Blood protein levels; CRC cis rs898097 0.812 rs56405605 chr17:80843663 T/C cg15664640 chr17:80829946 TBCD -0.71 -11.94 -0.55 1.51e-27 Breast cancer; CRC cis rs4750440 0.642 rs7921741 chr10:14030776 G/A cg00551146 chr10:14014579 FRMD4A 0.37 5.91 0.31 8.59e-9 Adiponectin levels; CRC cis rs9549367 0.713 rs510160 chr13:113822481 A/G cg18105134 chr13:113819100 PROZ 0.83 13.38 0.59 6.67e-33 Platelet distribution width; CRC cis rs13108904 0.967 rs4642180 chr4:1278914 T/C cg00684032 chr4:1343700 KIAA1530 0.48 7.09 0.36 8.27e-12 Obesity-related traits; CRC cis rs76878669 0.515 rs12576299 chr11:66132286 T/C cg18002602 chr11:66138449 SLC29A2 0.28 6.03 0.32 4.42e-9 Educational attainment (years of education); CRC cis rs1005277 0.505 rs10827835 chr10:38150709 G/A cg25427524 chr10:38739819 LOC399744 0.74 12.99 0.58 1.92e-31 Extrinsic epigenetic age acceleration; CRC cis rs6963495 0.818 rs73190161 chr7:105156871 C/T cg02135003 chr7:105160482 PUS7 -0.9 -12.2 -0.56 1.71e-28 Bipolar disorder (body mass index interaction); CRC cis rs4481887 0.676 rs6691314 chr1:248548020 G/A cg26353448 chr1:248524236 OR2T4 -0.31 -5.91 -0.31 8.39e-9 Common traits (Other); CRC cis rs7647973 1.000 rs1464569 chr3:49460350 A/G cg20833759 chr3:49053208 WDR6;DALRD3 0.55 8.47 0.42 8.48e-16 Menarche (age at onset); CRC cis rs4679121 0.730 rs62264698 chr3:126159711 T/G cg05485589 chr3:126194908 ZXDC -0.8 -5.67 -0.3 3.12e-8 Pursuit maintenance gain; CRC cis rs6831352 0.589 rs1133483 chr4:100023923 G/C cg13256891 chr4:100009986 ADH5 0.58 8.85 0.44 5.5e-17 Alcohol dependence; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg08907850 chr10:1094976 IDI1 0.54 6.98 0.36 1.63e-11 Thyroid stimulating hormone; CRC cis rs12497850 0.627 rs4974078 chr3:49009386 C/T cg02487422 chr3:49467188 NICN1 0.39 6.47 0.34 3.58e-10 Parkinson's disease; CRC cis rs1401999 0.714 rs1533683 chr3:183635488 C/T cg01324343 chr3:183735012 ABCC5 0.67 10.89 0.51 8.91e-24 Anterior chamber depth; CRC cis rs6445525 0.806 rs4688634 chr3:66008310 A/G cg06109867 chr3:66002991 MAGI1 -0.37 -5.92 -0.31 8.08e-9 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg14083397 chr20:388473 RBCK1 0.45 6.53 0.34 2.45e-10 Intelligence (multi-trait analysis); CRC cis rs7089973 0.872 rs7918388 chr10:116614563 T/C cg03647239 chr10:116582469 FAM160B1 0.41 5.75 0.3 2.01e-8 Bipolar disorder or attention deficit hyperactivity disorder; CRC cis rs4665809 1.000 rs6546768 chr2:26328800 A/G cg26119090 chr2:26468346 HADHA;HADHB -0.6 -7.61 -0.39 3e-13 Gut microbiome composition (summer); CRC cis rs16867321 0.950 rs1919152 chr2:181507765 C/T cg23363182 chr2:181467187 NA -0.51 -6.51 -0.34 2.83e-10 Obesity; CRC cis rs8044868 0.512 rs4788461 chr16:72156000 C/A cg06172871 chr16:72088244 HP 0.41 6.05 0.32 4e-9 Body mass index (change over time) in cancer or chronic obstructive pulmonary disease;Body mass index (change over time) in cancer; CRC cis rs989128 0.600 rs2240218 chr17:48630580 A/T cg24438145 chr17:48624694 SPATA20 0.44 6.37 0.33 6.46e-10 Type 2 diabetes; CRC cis rs727505 0.954 rs66691367 chr7:124654217 G/T cg23710748 chr7:124431027 NA -0.81 -14.1 -0.61 1.26e-35 Lewy body disease; CRC cis rs4076764 0.846 rs12035840 chr1:163419177 G/C cg06092702 chr1:163392909 NA -0.55 -8.78 -0.44 9.18e-17 Motion sickness; CRC cis rs6921919 0.806 rs213230 chr6:28330264 A/G cg21251018 chr6:28226885 NKAPL 0.39 5.8 0.3 1.59e-8 Autism spectrum disorder or schizophrenia; CRC cis rs2032447 0.832 rs10425 chr6:26056549 A/G cg18357526 chr6:26021779 HIST1H4A 0.7 10.58 0.5 1.03e-22 Intelligence (multi-trait analysis); CRC cis rs7833986 0.501 rs2976044 chr8:56986737 A/G cg23139584 chr8:56987506 RPS20;SNORD54 0.69 9.87 0.48 2.72e-20 Height; CRC cis rs17270561 0.609 rs2000351 chr6:25759783 T/C cg17691542 chr6:26056736 HIST1H1C 0.64 8.14 0.41 8.02e-15 Iron status biomarkers; CRC cis rs274567 0.501 rs274571 chr5:131712125 A/G cg11843238 chr5:131593191 PDLIM4 -0.44 -7.48 -0.38 6.7e-13 Blood metabolite levels; CRC cis rs7085104 0.660 rs3781286 chr10:104595719 C/T cg04362960 chr10:104952993 NT5C2 0.6 8.92 0.44 3.39e-17 Immature fraction of reticulocytes;Schizophrenia; CRC cis rs709400 0.628 rs7146506 chr14:103924477 A/G cg12935359 chr14:103987150 CKB -0.48 -7.73 -0.39 1.36e-13 Body mass index; CRC trans rs1814175 0.692 rs1851873 chr11:49937767 A/G cg03929089 chr4:120376271 NA -0.75 -12.32 -0.56 5.96e-29 Height; CRC cis rs2749592 0.531 rs994804 chr10:37900140 A/C cg25517755 chr10:38738941 LOC399744 0.41 5.91 0.31 8.44e-9 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs1448094 0.511 rs10863083 chr12:86226739 C/A cg19622623 chr12:86230825 RASSF9 -0.4 -6.48 -0.34 3.3e-10 Major depressive disorder; CRC cis rs7927771 0.507 rs10838754 chr11:47758532 A/C cg20307385 chr11:47447363 PSMC3 0.45 6.3 0.33 9.5e-10 Subjective well-being; CRC cis rs4789294 0.806 rs9910471 chr17:74393478 G/C cg06840243 chr17:74442338 UBE2O 0.41 6.04 0.32 4.22e-9 Lymphocyte percentage of white cells; CRC trans rs3733585 0.699 rs28837683 chr4:9959808 C/T cg26043149 chr18:55253948 FECH -0.48 -7.43 -0.38 9.29e-13 Cleft plate (environmental tobacco smoke interaction); CRC cis rs1577917 0.916 rs12661611 chr6:86553835 G/A cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.44 -5.78 -0.3 1.75e-8 Response to antipsychotic treatment; CRC cis rs34375054 0.672 rs58416336 chr12:125606428 G/T cg25124228 chr12:125621409 AACS -0.58 -9.52 -0.46 3.8e-19 Post bronchodilator FEV1/FVC ratio; CRC cis rs704795 0.805 rs1728926 chr2:27612937 A/G cg21248554 chr2:27665150 KRTCAP3 -0.31 -7.15 -0.37 5.67e-12 Menopause (age at onset); CRC cis rs10499694 0.933 rs11575352 chr7:50594982 A/G cg14593290 chr7:50529359 DDC -0.44 -6.4 -0.33 5.38e-10 Body mass index; CRC cis rs2576037 0.583 rs530205 chr18:44385150 C/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.63 10.75 0.51 2.58e-23 Personality dimensions; CRC cis rs738322 0.934 rs133016 chr22:38572582 C/T cg25457927 chr22:38595422 NA -0.36 -7.57 -0.39 3.83e-13 Cutaneous nevi; CRC trans rs783540 0.592 rs2567632 chr15:83284804 A/G cg18393722 chr15:85113863 UBE2QP1 -0.39 -6.13 -0.32 2.46e-9 Schizophrenia; CRC cis rs10504229 1.000 rs17217047 chr8:58180296 G/A cg24829409 chr8:58192753 C8orf71 -0.68 -11.34 -0.53 2.27e-25 Developmental language disorder (linguistic errors); CRC cis rs1475911 1.000 rs2839465 chr21:43511232 C/T cg24372256 chr21:43528868 UMODL1;C21orf128 -0.54 -6.97 -0.36 1.77e-11 IgG glycosylation; CRC cis rs3796352 1.000 rs3796352 chr3:52913279 C/T cg27565382 chr3:53032988 SFMBT1 0.81 6.46 0.34 3.82e-10 Immune reponse to smallpox (secreted IL-2); CRC cis rs6951245 0.554 rs10270249 chr7:1151886 G/T cg03188948 chr7:1209495 NA 0.53 6.35 0.33 7.06e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs4253772 0.530 rs6008662 chr22:46713917 G/A cg09491104 chr22:46646882 C22orf40 -0.43 -6.38 -0.33 6.18e-10 LDL cholesterol;Cholesterol, total; CRC cis rs9322193 0.884 rs9322210 chr6:150016576 G/A cg13206674 chr6:150067644 NUP43 0.64 9.49 0.46 4.85e-19 Lung cancer; CRC cis rs9549367 0.713 rs510160 chr13:113822481 A/G cg24300038 chr13:113819356 PROZ 0.49 6.61 0.34 1.58e-10 Platelet distribution width; CRC cis rs597539 0.654 rs619727 chr11:68627535 A/G cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.85 14.66 0.63 8.41e-38 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs1552244 1.000 rs17032414 chr3:10158302 C/G cg18598329 chr3:10140678 FANCD2;C3orf24 -0.87 -12.58 -0.57 6.72e-30 Alzheimer's disease; CRC cis rs56399783 0.901 rs73033407 chr7:2878857 G/C cg19731401 chr7:2775893 GNA12 0.62 6.26 0.33 1.17e-9 Childhood ear infection; CRC trans rs7395662 0.609 rs10839190 chr11:48957008 T/C cg21153622 chr11:89784906 NA 0.45 7.14 0.37 5.85e-12 HDL cholesterol; CRC cis rs9649213 0.593 rs1468338 chr7:97951118 T/C cg24562669 chr7:97807699 LMTK2 0.42 7.04 0.36 1.1e-11 Prostate cancer (SNP x SNP interaction); CRC cis rs736408 0.509 rs13083798 chr3:52649748 A/G cg11645453 chr3:52864694 ITIH4 0.32 5.99 0.31 5.44e-9 Bipolar disorder; CRC cis rs4665809 1.000 rs10048683 chr2:26320519 C/T cg22920501 chr2:26401640 FAM59B -0.52 -7.11 -0.37 7.15e-12 Gut microbiome composition (summer); CRC cis rs1448094 0.512 rs1900701 chr12:86236231 T/C cg25456477 chr12:86230367 RASSF9 0.32 5.63 0.3 3.87e-8 Major depressive disorder; CRC cis rs9911578 0.967 rs12603238 chr17:57130785 C/T cg05425664 chr17:57184151 TRIM37 0.51 8.06 0.41 1.38e-14 Intelligence (multi-trait analysis); CRC cis rs1552244 0.766 rs34232505 chr3:10186216 T/A cg16606324 chr3:10149918 C3orf24 0.69 9.06 0.45 1.15e-17 Alzheimer's disease; CRC trans rs11581859 0.950 rs58724269 chr1:99372616 C/T cg12183875 chr3:169587454 LRRC31 0.27 6.43 0.33 4.37e-10 Response to cognitive-behavioural therapy in anxiety disorder; CRC cis rs9462027 0.628 rs7752060 chr6:34760325 T/C cg07306190 chr6:34760872 UHRF1BP1 -0.35 -6.23 -0.33 1.4e-9 Systemic lupus erythematosus; CRC cis rs7746199 0.668 rs34864796 chr6:27459923 G/A cg12273811 chr6:28175739 NA 0.68 5.73 0.3 2.22e-8 Gait speed in old age;Autism spectrum disorder or schizophrenia; CRC cis rs3087591 0.922 rs9892839 chr17:29618990 A/G cg24425628 chr17:29625626 OMG;NF1 -0.84 -16.46 -0.67 7.77e-45 Hip circumference; CRC cis rs7258465 0.897 rs1043327 chr19:18554972 A/G cg10790698 chr19:18539756 SSBP4 -0.46 -8.78 -0.44 9.28e-17 Breast cancer; CRC cis rs72717009 0.825 rs7552317 chr1:161479438 C/T cg23840854 chr1:161414152 NA -0.65 -8.0 -0.4 2.11e-14 Rheumatoid arthritis; CRC cis rs2075371 0.897 rs1646702 chr7:134000177 C/G cg20476274 chr7:133979776 SLC35B4 0.79 14.13 0.61 9.31e-36 Mean platelet volume; CRC trans rs2303319 0.504 rs62187656 chr2:162487699 A/G cg16721101 chr20:25176146 ENTPD6 -0.7 -6.08 -0.32 3.35e-9 Cognitive function; CRC cis rs911119 0.866 rs4346460 chr20:23569400 C/T cg16589663 chr20:23618590 CST3 0.42 5.93 0.31 7.51e-9 Chronic kidney disease; CRC trans rs1864729 1.000 rs2635162 chr8:98283629 C/T cg08679828 chr8:102218111 ZNF706 -0.59 -7.52 -0.38 5.11e-13 Estradiol plasma levels (breast cancer); CRC cis rs9486719 0.948 rs11153059 chr6:97014537 T/A cg18709589 chr6:96969512 KIAA0776 -0.52 -5.85 -0.31 1.21e-8 Migraine;Coronary artery disease; CRC cis rs539514 0.664 rs634729 chr13:76307981 C/T cg04757411 chr13:76259545 LMO7 -0.35 -5.97 -0.31 6.25e-9 Type 1 diabetes; CRC cis rs2228479 0.850 rs62054638 chr16:89821131 G/C cg06558623 chr16:89946397 TCF25 1.13 10.45 0.5 2.85e-22 Skin colour saturation; CRC cis rs4604732 0.631 rs10802509 chr1:247627158 C/T cg02104434 chr1:247694406 LOC148824;OR2C3 0.6 8.82 0.44 6.67e-17 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CRC cis rs315934 0.664 rs315921 chr2:113872051 C/T cg24553058 chr2:113831203 IL1F10 -0.52 -5.67 -0.3 3.15e-8 Dysmenorrheic pain; CRC cis rs9534288 0.664 rs1926446 chr13:46629995 A/C cg15192986 chr13:46630673 CPB2 0.68 10.13 0.49 3.55e-21 Blood protein levels; CRC cis rs8177253 0.665 rs10935074 chr3:133441692 T/G cg16262614 chr3:133464971 TF 0.34 6.2 0.32 1.69e-9 Iron status biomarkers; CRC cis rs1669338 0.588 rs3931974 chr3:3186894 A/G cg16797762 chr3:3221439 CRBN 0.6 5.72 0.3 2.43e-8 White matter integrity; CRC cis rs4148883 0.628 rs34195655 chr4:100073795 C/T cg13256891 chr4:100009986 ADH5 0.42 6.08 0.32 3.28e-9 Alcohol dependence; CRC cis rs9322193 0.923 rs10782317 chr6:150075047 C/T cg07701084 chr6:150067640 NUP43 -0.59 -8.74 -0.43 1.2e-16 Lung cancer; CRC cis rs7940866 0.774 rs10894292 chr11:130820757 C/T cg12179176 chr11:130786555 SNX19 0.61 8.97 0.44 2.35e-17 Schizophrenia; CRC cis rs1348850 0.537 rs3770010 chr2:178537796 T/C cg22681709 chr2:178499509 PDE11A -0.44 -8.16 -0.41 7.37e-15 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs909674 0.541 rs5750812 chr22:39793079 G/A cg24399712 chr22:39784796 NA -0.53 -11.41 -0.53 1.25e-25 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; CRC cis rs4711350 0.862 rs602399 chr6:33713779 C/T cg07979401 chr6:33739406 LEMD2 0.48 6.0 0.31 5.1e-9 Schizophrenia; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg11801572 chr13:77601451 FBXL3 0.43 6.21 0.32 1.59e-9 Intelligence (multi-trait analysis); CRC cis rs6502050 0.805 rs9898326 chr17:80119582 C/T cg25804541 chr17:80189381 SLC16A3 -0.31 -5.95 -0.31 6.84e-9 Life satisfaction; CRC cis rs2882667 0.690 rs1651358 chr5:138081007 A/G cg09476006 chr5:138032270 NA -0.55 -9.64 -0.47 1.54e-19 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs282587 0.627 rs388242 chr13:113415188 T/C cg04656015 chr13:113407548 ATP11A 0.62 7.98 0.4 2.52e-14 Glycated hemoglobin levels; CRC cis rs4253772 0.637 rs8139035 chr22:46651367 A/G cg03482458 chr22:46692211 CN5H6.4;GTSE1 0.48 6.36 0.33 6.94e-10 LDL cholesterol;Cholesterol, total; CRC cis rs35520189 0.557 rs12617864 chr2:113714976 G/T cg12858261 chr2:113808755 IL1F8 -0.47 -6.68 -0.35 1.02e-10 Obstructive sleep apnea trait (apnea hypopnea index); CRC cis rs11148252 0.846 rs7985262 chr13:52997161 C/T cg12458913 chr13:53173898 NA 0.52 8.02 0.4 1.88e-14 Lewy body disease; CRC cis rs6860806 0.507 rs272882 chr5:131669161 G/T cg20512303 chr5:131592959 PDLIM4 0.38 6.68 0.35 1.01e-10 Breast cancer; CRC cis rs17384381 1.000 rs35193119 chr1:85859265 T/C cg16011679 chr1:85725395 C1orf52 0.64 6.56 0.34 2.1e-10 Lobe attachment (rater-scored or self-reported); CRC cis rs2204008 0.743 rs11182052 chr12:38450421 T/C cg13010199 chr12:38710504 ALG10B 0.49 6.6 0.34 1.68e-10 Bladder cancer; CRC trans rs208520 0.526 rs9363522 chr6:66816642 C/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.17 -25.11 -0.81 1.83e-78 Exhaled nitric oxide output; CRC cis rs10504229 0.679 rs11783963 chr8:58130496 T/A cg22535103 chr8:58192502 C8orf71 -0.7 -9.34 -0.46 1.47e-18 Developmental language disorder (linguistic errors); CRC cis rs35883536 0.626 rs10493933 chr1:101111282 A/G cg06223162 chr1:101003688 GPR88 -0.34 -5.82 -0.31 1.43e-8 Monocyte count; CRC cis rs17767392 0.836 rs61989383 chr14:71983644 T/C cg13720639 chr14:72061746 SIPA1L1 -0.53 -6.87 -0.35 3.2e-11 Mitral valve prolapse; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg20317180 chr19:56111252 FIZ1;ZNF524 0.48 6.27 0.33 1.14e-9 Thyroid stimulating hormone; CRC cis rs6089584 0.888 rs2146853 chr20:60617908 A/T cg13770153 chr20:60521292 NA -0.58 -8.81 -0.44 7.37e-17 Body mass index; CRC trans rs941408 0.515 rs7253128 chr19:2776982 C/T cg22153745 chr1:153894579 GATAD2B -0.57 -7.89 -0.4 4.58e-14 Total cholesterol levels; CRC cis rs8077889 0.917 rs1859048 chr17:41892039 A/C cg25876840 chr17:41920477 NA -0.53 -7.8 -0.4 8.01e-14 Triglycerides; CRC cis rs3751196 0.901 rs74901375 chr12:104199707 C/T cg02344784 chr12:104178138 NT5DC3 0.69 6.98 0.36 1.67e-11 Sense of smell; CRC cis rs992157 0.835 rs34353396 chr2:219153982 T/C cg00012203 chr2:219082015 ARPC2 -0.47 -7.13 -0.37 6.5e-12 Colorectal cancer; CRC cis rs35883536 1.000 rs11586815 chr1:101089079 C/T cg14515779 chr1:101123966 NA -0.42 -8.11 -0.41 1.02e-14 Monocyte count; CRC cis rs62229266 0.771 rs7280136 chr21:37432910 C/G cg08632701 chr21:37451849 NA 0.4 6.29 0.33 1.03e-9 Mitral valve prolapse; CRC cis rs6570726 0.791 rs436498 chr6:145876347 G/A cg23711669 chr6:146136114 FBXO30 0.77 13.41 0.59 5.06e-33 Lobe attachment (rater-scored or self-reported); CRC cis rs11112613 0.713 rs11112590 chr12:105951376 C/G cg03607813 chr12:105948248 NA -0.83 -10.86 -0.51 1.13e-23 Corrected insulin response;Corrected insulin response adjusted for insulin sensitivity index; CRC cis rs34375054 0.624 rs4073534 chr12:125671800 C/T cg20959480 chr12:125599568 AACS 0.39 5.69 0.3 2.83e-8 Post bronchodilator FEV1/FVC ratio; CRC cis rs9517320 0.534 rs3858778 chr13:99172249 A/C cg07423050 chr13:99094983 FARP1 0.54 7.81 0.4 7.84e-14 Longevity; CRC cis rs6860806 0.661 rs2171247 chr5:131580234 G/T cg09877947 chr5:131593287 PDLIM4 0.44 7.99 0.4 2.37e-14 Breast cancer; CRC cis rs2066819 1.000 rs76430365 chr12:56699993 A/C cg26714650 chr12:56694279 CS -1.38 -11.56 -0.54 3.59e-26 Psoriasis vulgaris; CRC cis rs1129187 0.967 rs11752813 chr6:42928017 C/G cg21280719 chr6:42927975 GNMT -0.44 -9.57 -0.47 2.67e-19 Alzheimer's disease in APOE e4+ carriers; CRC cis rs1568889 0.887 rs7102237 chr11:28344296 A/C cg06544937 chr11:28130018 METT5D1;KIF18A 0.91 15.5 0.65 4.52e-41 Bipolar disorder; CRC cis rs7119 0.651 rs17394732 chr15:77835657 A/G cg10437265 chr15:77819839 NA -0.68 -12.24 -0.56 1.2e-28 Type 2 diabetes; CRC cis rs875971 0.862 rs11773628 chr7:65982631 G/T cg12463550 chr7:65579703 CRCP -0.48 -6.61 -0.34 1.51e-10 Aortic root size; CRC cis rs7605827 0.866 rs2287275 chr2:15658828 C/T cg19274914 chr2:15703543 NA 0.39 5.89 0.31 9.8e-9 Educational attainment (years of education); CRC cis rs9894429 0.966 rs6565604 chr17:79589242 G/A cg18240062 chr17:79603768 NPLOC4 0.56 9.32 0.46 1.78e-18 Eye color traits; CRC cis rs9361491 0.543 rs1507153 chr6:79484386 C/A cg05283184 chr6:79620031 NA -0.44 -6.38 -0.33 5.87e-10 Intelligence (multi-trait analysis); CRC cis rs514406 0.505 rs269286 chr1:53169018 C/T cg08859206 chr1:53392774 SCP2 0.44 6.82 0.35 4.5e-11 Monocyte count; CRC cis rs12541335 0.590 rs11136002 chr8:22217082 C/T cg27266060 chr8:22091797 NA 0.35 5.8 0.3 1.53e-8 Hypertriglyceridemia; CRC trans rs66573146 0.803 rs60228659 chr4:7031704 G/A cg07817883 chr1:32538562 TMEM39B 1.24 10.63 0.51 6.95e-23 Granulocyte percentage of myeloid white cells; CRC cis rs10504229 0.683 rs6999131 chr8:58127052 C/A cg22535103 chr8:58192502 C8orf71 -0.72 -8.13 -0.41 8.7e-15 Developmental language disorder (linguistic errors); CRC cis rs9467773 0.595 rs2451736 chr6:26620544 G/A cg09904177 chr6:26538194 HMGN4 0.72 11.21 0.53 6.63e-25 Intelligence (multi-trait analysis); CRC cis rs77956314 0.515 rs10850733 chr12:117380961 G/A cg25972092 chr12:117363249 FBXW8 0.56 6.66 0.34 1.17e-10 Subcortical brain region volumes;Hippocampal volume; CRC cis rs12477438 0.520 rs6542866 chr2:99764592 T/C cg26064155 chr2:99771622 LIPT1;TSGA10 0.78 13.38 0.59 6.83e-33 Chronic sinus infection; CRC cis rs3018066 0.748 rs11942153 chr4:106960172 C/T cg01869342 chr4:106983673 TBCK 0.45 6.8 0.35 4.97e-11 Cancer; CRC cis rs11166629 1.000 rs1867059 chr8:135647019 A/G cg27224718 chr8:135614730 ZFAT 0.52 7.67 0.39 1.95e-13 Smoking quantity; CRC cis rs7527798 0.592 rs1323722 chr1:207823405 C/T cg09232269 chr1:207846808 CR1L -0.51 -8.25 -0.41 3.81e-15 Erythrocyte sedimentation rate; CRC cis rs7647973 0.710 rs11130208 chr3:49615624 G/T cg13072238 chr3:49761600 GMPPB -0.54 -5.85 -0.31 1.19e-8 Menarche (age at onset); CRC cis rs977987 0.800 rs3784935 chr16:75336430 T/G cg03315344 chr16:75512273 CHST6 0.54 9.02 0.45 1.65e-17 Dupuytren's disease; CRC cis rs9303401 0.659 rs1864754 chr17:56688789 G/T cg10487724 chr17:56770010 TEX14;RAD51C -0.78 -9.79 -0.48 4.8e-20 Cognitive test performance; CRC cis rs6840360 0.533 rs13121190 chr4:152729072 T/G cg09659197 chr4:152720779 NA -0.42 -8.51 -0.42 6.31e-16 Intelligence (multi-trait analysis); CRC cis rs1799949 0.550 rs2343818 chr17:41409774 G/A cg23758822 chr17:41437982 NA 0.81 13.62 0.6 8.16e-34 Menopause (age at onset); CRC cis rs9911578 0.839 rs1871751 chr17:57190368 A/G cg12560992 chr17:57184187 TRIM37 0.92 17.42 0.69 1.29e-48 Intelligence (multi-trait analysis); CRC cis rs9733 0.596 rs6681990 chr1:150695929 A/G cg18016565 chr1:150552671 MCL1 0.45 6.52 0.34 2.57e-10 Tonsillectomy; CRC cis rs6582630 0.554 rs7299735 chr12:38450890 A/C cg13010199 chr12:38710504 ALG10B -0.42 -5.94 -0.31 7.34e-9 Drug-induced liver injury (flucloxacillin); CRC cis rs8072100 0.713 rs9895776 chr17:45486003 A/G cg08085267 chr17:45401833 C17orf57 -0.58 -8.75 -0.43 1.11e-16 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs11785400 1.000 rs13265663 chr8:143732255 A/C cg10596483 chr8:143751796 JRK 0.49 7.0 0.36 1.46e-11 Schizophrenia; CRC cis rs7811142 1.000 rs11764818 chr7:100043055 G/A cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.99 13.63 0.6 7.31e-34 Platelet count; CRC cis rs6546550 0.935 rs2168115 chr2:70034793 A/G cg02498382 chr2:70120550 SNRNP27 -0.47 -7.78 -0.39 9.29e-14 Prevalent atrial fibrillation; CRC cis rs2842992 0.724 rs4709368 chr6:160204127 C/T cg11366901 chr6:160182831 ACAT2 -0.72 -11.0 -0.52 3.61e-24 Age-related macular degeneration (geographic atrophy); CRC cis rs9462027 0.527 rs11755393 chr6:34824636 A/G cg07306190 chr6:34760872 UHRF1BP1 -0.34 -5.9 -0.31 9.06e-9 Systemic lupus erythematosus; CRC cis rs8180040 0.966 rs12486969 chr3:47429003 G/C cg27129171 chr3:47204927 SETD2 -0.6 -9.37 -0.46 1.19e-18 Colorectal cancer; CRC cis rs10504229 1.000 rs72650899 chr8:58180525 G/T cg22535103 chr8:58192502 C8orf71 -0.82 -12.27 -0.56 9.63e-29 Developmental language disorder (linguistic errors); CRC cis rs6499255 1.000 rs11641521 chr16:69823081 C/G cg04110750 chr16:69646130 NFAT5 -0.53 -7.13 -0.37 6.45e-12 IgE levels; CRC cis rs6089584 0.546 rs6061980 chr20:60618877 G/A cg13770153 chr20:60521292 NA -0.43 -6.48 -0.34 3.32e-10 Body mass index; CRC cis rs6500602 0.701 rs4785969 chr16:4536934 A/T cg14951292 chr16:4525986 HMOX2;NMRAL1 0.79 11.59 0.54 2.81e-26 Schizophrenia; CRC cis rs4478858 0.735 rs12408524 chr1:31835853 A/G cg00250761 chr1:31883323 NA -0.42 -7.75 -0.39 1.14e-13 Alcohol dependence; CRC cis rs752010 1.000 rs4999015 chr1:42093547 G/A cg06885757 chr1:42089581 HIVEP3 0.49 8.52 0.43 5.72e-16 Lupus nephritis in systemic lupus erythematosus; CRC trans rs3780486 0.846 rs7873903 chr9:33142728 G/A cg20290983 chr6:43655470 MRPS18A 1.18 25.39 0.81 1.6e-79 IgG glycosylation; CRC cis rs9467711 0.606 rs2076030 chr6:26426856 G/A cg12315302 chr6:26189340 HIST1H4D 0.77 5.99 0.31 5.51e-9 Autism spectrum disorder or schizophrenia; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg22664697 chr19:2819641 ZNF554 0.37 5.97 0.31 6.05e-9 Liver disease severity in Alagille syndrome; CRC cis rs7727544 0.901 rs55633655 chr5:131598756 T/G cg18301423 chr5:131593218 PDLIM4 0.29 5.69 0.3 2.86e-8 Blood metabolite levels; CRC cis rs3018066 0.867 rs13113845 chr4:107172377 C/G cg01869342 chr4:106983673 TBCK -0.36 -5.63 -0.3 3.82e-8 Cancer; CRC cis rs7923609 0.967 rs10509189 chr10:65264126 T/C cg08743896 chr10:65200160 JMJD1C -0.42 -5.94 -0.31 7.27e-9 Educational attainment;Liver enzyme levels (alkaline phosphatase); CRC cis rs9322193 0.924 rs9322189 chr6:149909933 T/C cg07701084 chr6:150067640 NUP43 0.57 8.15 0.41 7.5e-15 Lung cancer; CRC cis rs9807989 0.801 rs7558339 chr2:102970243 T/G cg03938978 chr2:103052716 IL18RAP 0.37 5.97 0.31 6.2e-9 Asthma; CRC cis rs3011225 0.683 rs4660753 chr1:44321044 G/A cg12908607 chr1:44402522 ARTN -0.53 -9.51 -0.46 4.11e-19 Amyotrophic lateral sclerosis (age of onset); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg22134634 chr17:57970430 TUBD1;RPS6KB1 0.44 6.01 0.31 5.03e-9 Response to antipsychotic treatment; CRC cis rs11098699 0.821 rs11942230 chr4:124199453 A/G cg09941581 chr4:124220074 SPATA5 0.41 5.95 0.31 6.87e-9 Mosquito bite size; CRC cis rs6500602 0.647 rs4786514 chr16:4576798 A/C cg13763550 chr16:4524223 NMRAL1;HMOX2 0.42 5.63 0.3 3.95e-8 Schizophrenia; CRC cis rs3749237 0.964 rs34522271 chr3:49808517 A/G cg24308560 chr3:49941425 MST1R -0.43 -6.18 -0.32 1.85e-9 Resting heart rate; CRC cis rs11212617 0.967 rs7395528 chr11:108056708 A/C cg12106634 chr11:108092400 ATM;NPAT 0.43 6.39 0.33 5.8e-10 Response to metformin in type 2 diabetes (glycemic); CRC cis rs4664293 0.585 rs10460301 chr2:160635077 A/G cg08347373 chr2:160653686 CD302 0.36 5.96 0.31 6.5e-9 Monocyte percentage of white cells; CRC cis rs2404602 0.716 rs17363713 chr15:76746128 G/C cg23625390 chr15:77176239 SCAPER 0.49 7.17 0.37 4.99e-12 Blood metabolite levels; CRC cis rs7618915 0.547 rs13085895 chr3:52678270 G/C cg05573699 chr3:52720067 GNL3;PBRM1 -0.47 -6.68 -0.35 1.02e-10 Bipolar disorder; CRC cis rs7786808 0.649 rs6459879 chr7:158211792 C/G cg01191920 chr7:158217561 PTPRN2 -0.58 -9.53 -0.47 3.66e-19 Obesity-related traits; CRC cis rs4290604 0.748 rs4621125 chr2:238080214 G/A cg23555395 chr2:238036564 NA -0.61 -6.14 -0.32 2.34e-9 Asthma; CRC cis rs6880778 0.505 rs7445978 chr5:40381056 A/T cg09067459 chr5:40385259 NA 0.46 8.01 0.4 2.07e-14 Inflammatory bowel disease; CRC cis rs17127169 0.536 rs112625995 chr1:65496627 A/G cg01340542 chr1:65468273 NA 0.98 6.86 0.35 3.38e-11 Sitting height ratio; CRC cis rs6541297 1.000 rs1998065 chr1:230286647 T/G cg05784532 chr1:230284198 GALNT2 0.43 5.79 0.3 1.66e-8 Coronary artery disease; CRC cis rs473651 0.503 rs515342 chr2:239367296 A/G cg04738700 chr2:239367308 NA -0.47 -6.03 -0.32 4.44e-9 Multiple system atrophy; CRC cis rs7727544 0.735 rs272881 chr5:131669264 G/A cg07395648 chr5:131743802 NA -0.4 -6.37 -0.33 6.4e-10 Blood metabolite levels; CRC trans rs11098499 0.789 rs9991166 chr4:120237851 G/A cg25214090 chr10:38739885 LOC399744 0.53 8.45 0.42 9.68e-16 Corneal astigmatism; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg17808901 chr3:39093368 WDR48 0.52 7.07 0.36 9.44e-12 Thyroid stimulating hormone; CRC cis rs172166 0.694 rs9295760 chr6:28147385 G/A cg15786705 chr6:28176104 NA 0.64 9.21 0.45 3.94e-18 Cardiac Troponin-T levels; CRC cis rs7811142 0.830 rs10085549 chr7:99983135 C/T cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.61 8.11 0.41 1.03e-14 Platelet count; CRC cis rs7584330 0.737 rs7595979 chr2:238364492 G/T cg11271282 chr2:238384023 NA 0.44 5.98 0.31 5.68e-9 Prostate cancer; CRC cis rs7224685 0.501 rs11649992 chr17:4026823 A/C cg05562828 chr17:3906858 NA -0.65 -11.11 -0.52 1.48e-24 Type 2 diabetes; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg09870606 chr16:74641419 GLG1 0.41 6.16 0.32 2.14e-9 Intelligence (multi-trait analysis); CRC trans rs1945213 0.694 rs7116741 chr11:55862620 C/T cg15704280 chr7:45808275 SEPT13 0.56 6.27 0.33 1.15e-9 Acute lymphoblastic leukemia (childhood); CRC cis rs9322193 0.962 rs62441335 chr6:150113794 G/A cg00933542 chr6:150070202 PCMT1 0.28 5.63 0.3 3.86e-8 Lung cancer; CRC cis rs6662572 0.737 rs6702764 chr1:46252717 A/G cg08644498 chr1:46502608 NA -0.43 -6.92 -0.36 2.43e-11 Blood protein levels; CRC cis rs910316 0.712 rs175037 chr14:75465038 T/C cg11812906 chr14:75593930 NEK9 -0.57 -8.73 -0.43 1.27e-16 Height; CRC cis rs1448094 0.511 rs4278581 chr12:86151054 A/G cg18827107 chr12:86230957 RASSF9 0.39 5.96 0.31 6.52e-9 Major depressive disorder; CRC cis rs514406 0.792 rs481440 chr1:53344976 C/T cg08859206 chr1:53392774 SCP2 -0.57 -8.91 -0.44 3.44e-17 Monocyte count; CRC cis rs10256972 0.681 rs12702016 chr7:1129392 C/T cg27094323 chr7:1216898 NA -0.38 -6.22 -0.32 1.53e-9 Longevity;Endometriosis; CRC trans rs3733585 0.699 rs6856127 chr4:9965443 T/C cg26043149 chr18:55253948 FECH -0.5 -7.65 -0.39 2.23e-13 Cleft plate (environmental tobacco smoke interaction); CRC cis rs477895 0.653 rs7939784 chr11:63910153 C/T cg05016508 chr11:63871570 FLRT1;MACROD1 0.53 6.83 0.35 4.22e-11 Mean platelet volume; CRC trans rs12599106 0.792 rs76039834 chr16:34598453 G/A cg01171360 chr6:293285 DUSP22 -0.46 -6.6 -0.34 1.61e-10 Menopause (age at onset); CRC cis rs2050392 0.771 rs303446 chr10:30728489 C/T cg25182066 chr10:30743637 MAP3K8 -0.41 -6.08 -0.32 3.4e-9 Inflammatory bowel disease; CRC cis rs858239 0.799 rs10279941 chr7:23370508 C/G cg00469287 chr7:23338798 C7orf30 0.48 6.22 0.32 1.51e-9 Cerebrospinal fluid biomarker levels; CRC cis rs7945705 0.712 rs61876274 chr11:9019190 A/T cg00186954 chr11:8933980 ST5;C11orf17 0.45 7.44 0.38 8.57e-13 Hemoglobin concentration; CRC cis rs1552244 0.706 rs279545 chr3:9972493 A/G cg00166722 chr3:10149974 C3orf24 0.41 5.76 0.3 1.95e-8 Alzheimer's disease; CRC cis rs9486719 0.843 rs2499792 chr6:96846264 A/C cg06623918 chr6:96969491 KIAA0776 0.79 8.57 0.43 4.23e-16 Migraine;Coronary artery disease; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg11610739 chr17:40075306 ACLY 0.41 6.0 0.31 5.22e-9 Intelligence (multi-trait analysis); CRC trans rs1997103 0.906 rs6593231 chr7:55402914 T/A cg20935933 chr6:143382018 AIG1 0.52 6.72 0.35 7.8e-11 QRS interval (sulfonylurea treatment interaction); CRC cis rs1215050 0.791 rs7688192 chr4:98900798 G/T cg05340658 chr4:99064831 C4orf37 -0.49 -7.34 -0.37 1.74e-12 Waist-to-hip ratio adjusted for body mass index; CRC cis rs9462027 0.628 rs2764198 chr6:34706128 T/C cg07306190 chr6:34760872 UHRF1BP1 -0.34 -6.07 -0.32 3.49e-9 Systemic lupus erythematosus; CRC cis rs12142240 0.659 rs111723629 chr1:46853361 G/T cg14993813 chr1:46806288 NSUN4 -0.48 -6.03 -0.32 4.47e-9 Menopause (age at onset); CRC cis rs13217239 0.646 rs2142685 chr6:27054497 C/T cg12292205 chr6:26970375 C6orf41 -0.51 -8.46 -0.42 9.08e-16 Schizophrenia; CRC cis rs73206853 0.841 rs6606683 chr12:110712212 T/G cg12870014 chr12:110450643 ANKRD13A 0.8 7.72 0.39 1.39e-13 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC cis rs1005277 0.522 rs7090858 chr10:38003670 A/C cg25427524 chr10:38739819 LOC399744 0.73 12.66 0.57 3.42e-30 Extrinsic epigenetic age acceleration; CRC cis rs3785574 0.962 rs2584633 chr17:61879501 T/C cg23090583 chr17:61904693 PSMC5;FTSJ3 0.66 9.59 0.47 2.2e-19 Height; CRC cis rs9467711 0.606 rs9379857 chr6:26367654 G/C cg14345882 chr6:26364793 BTN3A2 0.65 5.74 0.3 2.17e-8 Autism spectrum disorder or schizophrenia; CRC trans rs10411161 0.702 rs11878580 chr19:52388485 C/T cg22319618 chr22:45562946 NUP50 -0.65 -7.22 -0.37 3.63e-12 Breast cancer; CRC cis rs9420 0.961 rs7938083 chr11:57493622 C/A cg23127183 chr11:57508653 C11orf31 -0.52 -6.92 -0.36 2.38e-11 Schizophrenia; CRC cis rs8067545 0.641 rs4925060 chr17:19863258 C/G cg04132472 chr17:19861366 AKAP10 0.44 6.79 0.35 5.22e-11 Schizophrenia; CRC cis rs7940866 0.903 rs7942900 chr11:130839244 G/A cg12179176 chr11:130786555 SNX19 0.56 8.3 0.42 2.74e-15 Schizophrenia; CRC cis rs367615 0.537 rs431669 chr5:108663115 G/A cg17395555 chr5:108820864 NA 0.38 6.87 0.35 3.18e-11 Colorectal cancer (SNP x SNP interaction); CRC cis rs1957429 0.808 rs9783609 chr14:65352282 A/G cg23373153 chr14:65346875 NA 0.8 8.27 0.41 3.28e-15 Pediatric areal bone mineral density (radius); CRC cis rs10504229 0.815 rs17805008 chr8:58160185 G/T cg11062466 chr8:58055876 NA 0.45 5.93 0.31 7.79e-9 Developmental language disorder (linguistic errors); CRC cis rs7208859 0.623 rs11651858 chr17:29170718 A/G cg14008862 chr17:28927542 LRRC37B2 0.55 5.76 0.3 1.98e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs9311676 0.632 rs7624283 chr3:58369897 G/A cg06643156 chr3:58380774 PXK 0.42 6.39 0.33 5.78e-10 Systemic lupus erythematosus; CRC cis rs67311347 1.000 rs7617989 chr3:40512463 A/G cg09455208 chr3:40491958 NA -0.41 -8.29 -0.42 2.94e-15 Renal cell carcinoma; CRC cis rs769267 0.930 rs892022 chr19:19613381 G/A cg02546618 chr19:19431379 KIAA0892;SF4 0.43 5.86 0.31 1.1e-8 Tonsillectomy; CRC cis rs17376456 0.569 rs2924374 chr5:93151141 T/C cg25358565 chr5:93447407 FAM172A -0.64 -7.6 -0.39 3.17e-13 Diabetic retinopathy; CRC cis rs9902453 0.765 rs8079209 chr17:28186773 C/T cg26525008 chr17:28256777 EFCAB5;SSH2 0.66 10.76 0.51 2.49e-23 Coffee consumption (cups per day); CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg05998513 chr10:97321375 SORBS1 0.46 6.4 0.33 5.2400000000000005e-10 Anxiety disorder; CRC cis rs6496667 0.779 rs7168898 chr15:90943065 G/A cg04176472 chr15:90893244 GABARAPL3 0.58 7.58 0.39 3.6e-13 Rheumatoid arthritis; CRC cis rs9487051 1.000 rs9400272 chr6:109616762 A/G cg12927641 chr6:109611667 NA -0.33 -5.73 -0.3 2.25e-8 Reticulocyte fraction of red cells; CRC cis rs6696846 0.765 rs61822567 chr1:205078725 T/C cg03948781 chr1:205179583 DSTYK 0.4 5.63 0.3 3.93e-8 Red blood cell count; CRC cis rs9916302 0.904 rs2338755 chr17:37419317 C/T cg00129232 chr17:37814104 STARD3 0.51 7.59 0.39 3.36e-13 Glomerular filtration rate (creatinine); CRC cis rs863345 0.604 rs6697656 chr1:158520737 A/G cg12129480 chr1:158549410 OR10X1 -0.34 -7.1 -0.36 7.73e-12 Pneumococcal bacteremia; CRC cis rs8078723 0.630 rs60137005 chr17:38129996 A/T cg17467752 chr17:38218738 THRA 0.62 9.63 0.47 1.69e-19 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); CRC cis rs9292777 0.777 rs12523160 chr5:40385790 A/T cg09067459 chr5:40385259 NA -0.56 -9.28 -0.46 2.31e-18 Crohn's disease;Multiple sclerosis; CRC cis rs7927592 0.626 rs11228279 chr11:68309680 C/T cg16797656 chr11:68205561 LRP5 -0.48 -8.87 -0.44 4.67e-17 Total body bone mineral density; CRC cis rs9868809 0.881 rs13096357 chr3:48675856 C/A cg07636037 chr3:49044803 WDR6 -0.65 -6.42 -0.33 4.88e-10 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg05961215 chr15:35280640 ZNF770 0.44 6.2 0.32 1.7e-9 Response to antipsychotic treatment; CRC cis rs6912958 0.781 rs9450723 chr6:88226641 C/T cg08069147 chr6:88032118 GJB7;C6orf162 0.53 7.94 0.4 3.16e-14 Monocyte percentage of white cells; CRC cis rs13108904 0.557 rs1680030 chr4:1245500 A/T cg20092199 chr4:1342459 KIAA1530 -0.38 -6.17 -0.32 2.02e-9 Obesity-related traits; CRC cis rs12529935 0.609 rs77466181 chr6:90959209 G/A cg06866423 chr6:90926672 BACH2 0.75 7.0 0.36 1.46e-11 Systemic lupus erythematosus; CRC cis rs2075371 1.000 rs2598292 chr7:133988584 C/G cg02659138 chr7:134003124 SLC35B4 0.37 6.41 0.33 5.15e-10 Mean platelet volume; CRC cis rs28374715 0.662 rs28554139 chr15:41531084 C/T cg18705301 chr15:41695430 NDUFAF1 -0.91 -13.72 -0.6 3.43e-34 Ulcerative colitis; CRC trans rs11098499 0.954 rs2389803 chr4:120393511 A/G cg25214090 chr10:38739885 LOC399744 -0.66 -10.27 -0.49 1.2e-21 Corneal astigmatism; CRC trans rs853679 0.599 rs202906 chr6:28011652 C/T cg06606381 chr12:133084897 FBRSL1 0.77 7.48 0.38 6.87e-13 Depression; CRC cis rs853679 0.517 rs4713150 chr6:28136212 G/A cg06470822 chr6:28175283 NA 1.03 13.6 0.6 1.02e-33 Depression; CRC cis rs9914988 0.887 rs4795456 chr17:27072463 G/A cg20469991 chr17:27169893 C17orf63 -0.57 -6.98 -0.36 1.59e-11 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs6540559 0.673 rs6540560 chr1:209982073 A/G cg21951975 chr1:209979733 IRF6 -0.43 -6.01 -0.31 4.96e-9 Cleft lip with or without cleft palate; CRC cis rs477895 0.653 rs72918475 chr11:63878644 G/C cg18225595 chr11:63971243 STIP1 0.52 6.54 0.34 2.29e-10 Mean platelet volume; CRC cis rs7258465 1.000 rs7252848 chr19:18612351 C/G cg06462663 chr19:18546047 ISYNA1 0.45 6.82 0.35 4.31e-11 Breast cancer; CRC trans rs6762477 0.748 rs9831967 chr3:50217234 C/T cg21659725 chr3:3221576 CRBN -0.45 -6.67 -0.35 1.06e-10 Menarche (age at onset); CRC cis rs2832191 0.716 rs7509628 chr21:30454252 C/T cg08807101 chr21:30365312 RNF160 0.71 11.59 0.54 2.84e-26 Dental caries; CRC cis rs807669 1.000 rs807670 chr22:19154608 A/C cg02655711 chr22:19163373 SLC25A1 0.71 13.5 0.6 2.37e-33 Metabolite levels; CRC cis rs612683 0.599 rs2809823 chr1:101003762 C/A cg06223162 chr1:101003688 GPR88 0.49 9.91 0.48 1.98e-20 Breast cancer; CRC cis rs7945705 0.902 rs2016942 chr11:8938787 A/G cg14711859 chr11:8959438 ASCL3 -0.5 -8.07 -0.41 1.38e-14 Hemoglobin concentration; CRC cis rs12802200 0.561 rs7940600 chr11:572105 A/G cg16486109 chr11:613632 IRF7 0.59 10.58 0.5 1.02e-22 Systemic lupus erythematosus; CRC cis rs9372498 0.505 rs9481811 chr6:118801174 T/C cg22561889 chr6:118971681 C6orf204 0.51 6.52 0.34 2.67e-10 Diastolic blood pressure; CRC cis rs300703 0.678 rs423643 chr2:199648 A/C cg21211680 chr2:198530 NA 0.89 10.86 0.51 1.1e-23 Blood protein levels; CRC cis rs55665837 0.583 rs78843135 chr11:14411254 T/G cg05501817 chr11:14380813 RRAS2 -0.43 -5.95 -0.31 6.79e-9 Vitamin D levels; CRC cis rs3096299 0.503 rs9925045 chr16:89556476 T/C cg08392591 chr16:89556376 ANKRD11 0.47 6.23 0.32 1.44e-9 Multiple myeloma (IgH translocation); CRC trans rs2797160 0.967 rs1739358 chr6:126019736 G/A cg05039488 chr6:79577232 IRAK1BP1 0.5 7.41 0.38 1.07e-12 Endometrial cancer; CRC cis rs4285028 0.747 rs3732407 chr3:121416623 G/C cg20356878 chr3:121714668 ILDR1 -0.48 -6.4 -0.33 5.39e-10 Multiple sclerosis; CRC cis rs7216064 0.953 rs2086744 chr17:65849275 C/G cg12091567 chr17:66097778 LOC651250 -0.68 -7.87 -0.4 5.31e-14 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CRC cis rs9486715 0.929 rs7775721 chr6:97056979 C/T cg18709589 chr6:96969512 KIAA0776 -0.51 -7.49 -0.38 6.19e-13 Headache; CRC cis rs4665809 0.589 rs4665841 chr2:26448950 G/A cg04944784 chr2:26401820 FAM59B -0.86 -11.69 -0.54 1.25e-26 Gut microbiome composition (summer); CRC cis rs4780401 0.527 rs4780402 chr16:11839809 C/T cg01061890 chr16:11836724 TXNDC11 -0.46 -6.38 -0.33 5.99e-10 Rheumatoid arthritis; CRC cis rs12497850 0.805 rs6446198 chr3:49007638 T/A cg07636037 chr3:49044803 WDR6 1.03 18.28 0.71 4.94e-52 Parkinson's disease; CRC cis rs75920871 0.588 rs4938321 chr11:116852507 C/T cg01368799 chr11:117014884 PAFAH1B2 -0.42 -5.97 -0.31 6.14e-9 Subjective well-being; CRC cis rs1005277 0.557 rs1854563 chr10:38434961 G/A cg17219203 chr10:38645113 HSD17B7P2 -0.4 -5.68 -0.3 2.89e-8 Extrinsic epigenetic age acceleration; CRC cis rs265548 0.608 rs36690 chr19:17910483 C/T cg21960279 chr19:17905606 B3GNT3 0.46 7.37 0.38 1.41e-12 Tumor biomarkers; CRC cis rs79057730 0.599 rs4721086 chr7:821123 G/A cg05729249 chr7:766119 PRKAR1B;HEATR2 0.58 6.34 0.33 7.52e-10 Initial pursuit acceleration; CRC trans rs3733585 0.648 rs67820465 chr4:9975873 A/G cg26043149 chr18:55253948 FECH -0.48 -7.33 -0.37 1.84e-12 Cleft plate (environmental tobacco smoke interaction); CRC cis rs61160187 0.582 rs12655603 chr5:60204596 C/T cg16298547 chr5:60138761 ELOVL7 -0.28 -5.93 -0.31 7.59e-9 Educational attainment (years of education);Educational attainment (college completion); CRC trans rs853679 0.546 rs200490 chr6:27796935 G/T cg06606381 chr12:133084897 FBRSL1 -0.74 -6.49 -0.34 3.16e-10 Depression; CRC cis rs12142240 0.698 rs72677600 chr1:46834449 G/A cg00530320 chr1:46809349 NSUN4 0.57 7.56 0.38 3.94e-13 Menopause (age at onset); CRC cis rs9911578 0.967 rs72628392 chr17:56506160 A/G cg05425664 chr17:57184151 TRIM37 0.5 7.61 0.39 2.92e-13 Intelligence (multi-trait analysis); CRC cis rs10791323 0.572 rs1114367 chr11:133737304 G/T cg15485101 chr11:133734466 NA 0.47 8.13 0.41 9.13e-15 Childhood ear infection; CRC cis rs6912958 0.535 rs1753154 chr6:88032843 G/C cg04972856 chr6:88032051 C6orf162;GJB7 0.33 6.13 0.32 2.58e-9 Monocyte percentage of white cells; CRC cis rs9916302 0.861 rs644173 chr17:37430519 T/C cg15445000 chr17:37608096 MED1 0.41 8.98 0.44 2.16e-17 Glomerular filtration rate (creatinine); CRC cis rs2239547 0.563 rs4687699 chr3:53101224 C/T cg18404041 chr3:52824283 ITIH1 -0.31 -5.78 -0.3 1.7e-8 Schizophrenia; CRC cis rs11167764 1.000 rs6580220 chr5:141480558 G/A cg23435118 chr5:141488016 NDFIP1 -0.46 -7.28 -0.37 2.55e-12 Crohn's disease; CRC cis rs4820539 0.966 rs5751587 chr22:23470090 G/A cg14186256 chr22:23484241 RTDR1 0.92 18.38 0.71 2.04e-52 Bone mineral density; CRC cis rs4665809 0.567 rs6711402 chr2:26430983 A/G cg25036284 chr2:26402008 FAM59B -0.7 -8.49 -0.42 7.03e-16 Gut microbiome composition (summer); CRC cis rs4481887 0.830 rs28581861 chr1:248506028 T/G cg00666640 chr1:248458726 OR2T12 0.49 9.13 0.45 6.88e-18 Common traits (Other); CRC cis rs172166 0.769 rs149965 chr6:28018689 T/A cg12172441 chr6:28176163 NA 0.49 6.69 0.35 9.78e-11 Cardiac Troponin-T levels; CRC cis rs754466 0.651 rs10824584 chr10:79625947 G/A cg17075019 chr10:79541650 NA -0.89 -15.36 -0.65 1.55e-40 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs3806843 0.897 rs2531338 chr5:140136957 A/T cg19875535 chr5:140030758 IK -0.54 -8.65 -0.43 2.3e-16 Depressive symptoms (multi-trait analysis); CRC cis rs561341 1.000 rs4795670 chr17:30244839 T/C cg12193833 chr17:30244370 NA -0.58 -7.83 -0.4 6.56e-14 Hip circumference adjusted for BMI; CRC trans rs2727020 0.617 rs1917311 chr11:49422665 C/T cg15704280 chr7:45808275 SEPT13 -0.92 -17.19 -0.69 1.05e-47 Coronary artery disease; CRC cis rs10540 1.000 rs35898083 chr11:484469 C/T cg19913688 chr11:428466 ANO9 -0.73 -7.4 -0.38 1.18e-12 Body mass index; CRC cis rs1348850 0.958 rs11684320 chr2:178456346 T/C cg22681709 chr2:178499509 PDE11A -0.32 -6.02 -0.31 4.66e-9 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs7727544 0.735 rs274559 chr5:131720070 A/G cg12564285 chr5:131593104 PDLIM4 -0.33 -6.11 -0.32 2.83e-9 Blood metabolite levels; CRC cis rs1707322 1.000 rs7547284 chr1:46319565 C/G cg06784218 chr1:46089804 CCDC17 0.51 8.99 0.44 1.94e-17 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs7772486 0.875 rs2814874 chr6:146305895 C/T cg23711669 chr6:146136114 FBXO30 0.68 11.55 0.54 3.94e-26 Lobe attachment (rater-scored or self-reported); CRC cis rs3858526 0.959 rs1840179 chr11:5949148 A/G cg13902645 chr11:5959945 NA -0.64 -8.97 -0.44 2.35e-17 DNA methylation (variation); CRC cis rs7927592 0.672 rs10501398 chr11:68331715 C/G cg01657329 chr11:68192670 LRP5 0.58 9.71 0.47 9.32e-20 Total body bone mineral density; CRC cis rs1065852 0.526 rs56234624 chr22:42388826 A/G cg22189786 chr22:42395067 WBP2NL 0.43 6.35 0.33 6.98e-10 Response to serotonin reuptake inhibitors in major depressive disorder (plasma drug and metabolite levels); CRC cis rs9916302 0.904 rs10852933 chr17:37698194 G/T cg03013999 chr17:37608204 MED1 0.46 7.14 0.37 5.87e-12 Glomerular filtration rate (creatinine); CRC cis rs6740322 0.843 rs6727237 chr2:43562000 T/C cg06169590 chr2:43455088 ZFP36L2;LOC100129726 -0.57 -7.09 -0.36 8.1e-12 Coronary artery disease; CRC cis rs6433857 0.536 rs7557023 chr2:181350474 G/A cg23363182 chr2:181467187 NA -0.54 -8.14 -0.41 8.3e-15 Body mass index; CRC cis rs597539 0.652 rs674654 chr11:68698762 G/T cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.87 14.81 0.63 2.25e-38 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs965469 1.000 rs6037590 chr20:3374085 G/A cg25506879 chr20:3388711 C20orf194 -0.39 -5.68 -0.3 2.91e-8 IFN-related cytopenia; CRC cis rs9311676 0.656 rs4339119 chr3:58389462 A/G cg06643156 chr3:58380774 PXK 0.41 6.33 0.33 7.82e-10 Systemic lupus erythematosus; CRC cis rs2836974 0.897 rs13339986 chr21:40605982 T/C cg11890956 chr21:40555474 PSMG1 1.03 16.37 0.67 1.72e-44 Cognitive function; CRC cis rs55665837 1.000 rs12276938 chr11:14463488 C/G cg19336497 chr11:14380999 RRAS2 -0.4 -6.73 -0.35 7.53e-11 Vitamin D levels; CRC cis rs6545883 0.929 rs1186700 chr2:61663372 A/C cg15711740 chr2:61764176 XPO1 -0.46 -6.06 -0.32 3.78e-9 Tuberculosis; CRC cis rs8014204 0.747 rs2070598 chr14:75360906 C/T cg03030879 chr14:75389066 RPS6KL1 0.45 7.22 0.37 3.69e-12 Caffeine consumption; CRC cis rs8060686 0.641 rs73612208 chr16:68206844 G/A cg26727032 chr16:67993705 SLC12A4 -0.56 -7.48 -0.38 6.89e-13 HDL cholesterol;Metabolic syndrome; CRC cis rs4237845 0.804 rs10877034 chr12:58286444 T/C cg02175503 chr12:58329896 NA 0.59 8.54 0.43 4.96e-16 Intelligence (multi-trait analysis); CRC cis rs1799949 1.000 rs11653253 chr17:41182662 G/A cg23758822 chr17:41437982 NA 0.8 13.18 0.59 3.91e-32 Menopause (age at onset); CRC cis rs12545109 0.800 rs1595940 chr8:57398309 T/C cg09654669 chr8:57350985 NA -0.4 -5.73 -0.3 2.31e-8 Obesity-related traits; CRC cis rs10540 0.730 rs12789735 chr11:518509 G/A cg15790184 chr11:494944 RNH1 0.61 6.25 0.33 1.26e-9 Body mass index; CRC cis rs7412746 0.503 rs72704639 chr1:150798335 A/C cg15448220 chr1:150897856 SETDB1 0.47 7.02 0.36 1.26e-11 Melanoma; CRC cis rs7107174 0.892 rs11237450 chr11:78023356 C/A cg02023728 chr11:77925099 USP35 0.52 7.49 0.38 6.23e-13 Testicular germ cell tumor; CRC cis rs17826219 0.636 rs4055314 chr17:29079769 T/C cg13385521 chr17:29058706 SUZ12P 0.72 8.24 0.41 4.19e-15 Body mass index; CRC cis rs9311474 0.508 rs6786043 chr3:52604861 A/G cg05573699 chr3:52720067 GNL3;PBRM1 -0.47 -6.96 -0.36 1.9e-11 Electroencephalogram traits; CRC cis rs9311474 0.508 rs11714565 chr3:52606292 C/T cg15147215 chr3:52552868 STAB1 -0.64 -11.26 -0.53 4.1e-25 Electroencephalogram traits; CRC cis rs2842992 0.830 rs2758312 chr6:160153452 G/A cg11366901 chr6:160182831 ACAT2 0.98 14.33 0.62 1.63e-36 Age-related macular degeneration (geographic atrophy); CRC cis rs6460942 0.591 rs62448728 chr7:12332915 A/T cg20607287 chr7:12443886 VWDE -0.56 -6.15 -0.32 2.21e-9 Coronary artery disease; CRC cis rs2842992 0.724 rs15982 chr6:160199687 T/C cg16489826 chr6:160211363 TCP1;MRPL18 0.59 8.96 0.44 2.55e-17 Age-related macular degeneration (geographic atrophy); CRC cis rs9910055 0.529 rs228764 chr17:42185469 A/G cg19774624 chr17:42201019 HDAC5 0.44 5.9 0.31 9.24e-9 Total body bone mineral density; CRC cis rs4481887 1.000 rs4244174 chr1:248467956 A/G cg00666640 chr1:248458726 OR2T12 0.52 9.16 0.45 5.86e-18 Common traits (Other); CRC cis rs6540559 0.611 rs17015226 chr1:209970096 C/G cg22029157 chr1:209979665 IRF6 0.71 9.27 0.46 2.53e-18 Cleft lip with or without cleft palate; CRC cis rs10504229 0.683 rs61306359 chr8:58134646 G/A cg24829409 chr8:58192753 C8orf71 -0.55 -8.03 -0.4 1.71e-14 Developmental language disorder (linguistic errors); CRC cis rs66573146 1.000 rs56178503 chr4:6961748 C/T cg26116260 chr4:7069785 GRPEL1 -0.74 -5.76 -0.3 1.91e-8 Granulocyte percentage of myeloid white cells; CRC cis rs9457247 0.967 rs387733 chr6:167409771 C/T cg23791538 chr6:167370224 RNASET2 0.39 6.1 0.32 3.06e-9 Crohn's disease; CRC trans rs1005277 0.505 rs200935 chr10:38132810 T/A cg23533926 chr12:111358616 MYL2 -0.44 -6.44 -0.33 4.24e-10 Extrinsic epigenetic age acceleration; CRC cis rs3617 0.573 rs12638968 chr3:52919447 T/A cg15147215 chr3:52552868 STAB1 0.42 6.94 0.36 2.11e-11 Red blood cell count;Autism spectrum disorder or schizophrenia; CRC cis rs9549328 0.544 rs66893681 chr13:113617499 A/G cg20742385 chr13:113633654 MCF2L 0.56 9.5 0.46 4.54e-19 Systolic blood pressure; CRC cis rs17125944 0.686 rs7158645 chr14:53332152 C/T cg00686598 chr14:53173677 PSMC6 -0.62 -6.08 -0.32 3.25e-9 Alzheimer's disease (late onset); CRC cis rs11098499 0.863 rs13149407 chr4:120437825 A/G cg09307838 chr4:120376055 NA 0.68 10.31 0.49 8.96e-22 Corneal astigmatism; CRC trans rs7726839 0.540 rs12520279 chr5:657291 T/C cg25482853 chr8:67687455 SGK3 1.13 13.26 0.59 1.97e-32 Obesity-related traits; CRC cis rs59698941 0.550 rs60042615 chr5:132193220 A/G cg14825688 chr5:132208181 LEAP2 -0.4 -6.44 -0.33 4.19e-10 Apolipoprotein A-IV levels; CRC cis rs6456156 0.846 rs204293 chr6:167514481 T/C cg07741184 chr6:167504864 NA 0.35 6.02 0.31 4.78e-9 Primary biliary cholangitis; CRC cis rs9648716 1.000 rs10282499 chr7:140449834 C/T cg10747023 chr7:140774559 NA 0.44 5.77 0.3 1.8e-8 Type 2 diabetes; CRC cis rs6582630 0.519 rs11182021 chr12:38443709 A/T cg26384229 chr12:38710491 ALG10B -0.64 -9.57 -0.47 2.66e-19 Drug-induced liver injury (flucloxacillin); CRC cis rs7811142 1.000 rs11763511 chr7:100081944 G/A cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.08 15.27 0.64 3.58e-40 Platelet count; CRC cis rs12745968 0.532 rs10874724 chr1:93088183 C/A cg17283838 chr1:93427260 FAM69A -0.48 -6.46 -0.34 3.7e-10 Bipolar disorder and schizophrenia; CRC cis rs939658 1.000 rs8031019 chr15:79458512 C/T cg17916960 chr15:79447300 NA -0.41 -6.63 -0.34 1.37e-10 Refractive error; CRC cis rs9910055 0.531 rs6503490 chr17:42246656 A/G cg16434002 chr17:42200994 HDAC5 -0.51 -7.45 -0.38 8.33e-13 Total body bone mineral density; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg19462847 chr11:6633911 TAF10 0.49 7.17 0.37 4.88e-12 Response to antipsychotic treatment; CRC cis rs6502050 0.835 rs10163482 chr17:80110394 C/A cg11859384 chr17:80120422 CCDC57 -0.37 -5.85 -0.31 1.16e-8 Life satisfaction; CRC cis rs10504229 0.861 rs6990617 chr8:58182960 G/T cg01721255 chr8:58191610 C8orf71 0.49 6.17 0.32 2e-9 Developmental language disorder (linguistic errors); CRC cis rs644799 0.965 rs566877 chr11:95528045 G/A cg03916912 chr11:95522834 CEP57;FAM76B 0.95 18.15 0.71 1.71e-51 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs908922 1.000 rs1199150 chr1:152455602 T/C cg23254163 chr1:152506842 NA 0.38 6.43 0.33 4.59e-10 Hair morphology; CRC trans rs8073060 0.586 rs17638867 chr17:34052513 C/T cg19694781 chr19:47549865 TMEM160 1.03 14.01 0.61 2.58e-35 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; CRC cis rs4148883 0.645 rs2851287 chr4:100014548 G/A cg13256891 chr4:100009986 ADH5 0.45 6.46 0.34 3.85e-10 Alcohol dependence; CRC cis rs10078 0.559 rs2037077 chr5:447226 A/G cg08916839 chr5:415575 AHRR 0.74 7.65 0.39 2.18e-13 Fat distribution (HIV); CRC cis rs612683 0.536 rs1335753 chr1:101027157 G/T cg06223162 chr1:101003688 GPR88 0.35 6.3 0.33 9.44e-10 Breast cancer; CRC trans rs12408261 0.685 rs4085125 chr1:189277546 A/T cg02070205 chr10:30722105 MAP3K8 0.43 6.12 0.32 2.62e-9 Number of pregnancies; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg21395147 chr1:211849137 NEK2 0.36 5.97 0.31 6.27e-9 Liver disease severity in Alagille syndrome; CRC cis rs798554 0.610 rs2644297 chr7:2858906 A/C cg13628971 chr7:2884303 GNA12 0.43 6.76 0.35 6.35e-11 Height; CRC cis rs34779708 0.966 rs17500582 chr10:35498788 T/A cg03585969 chr10:35415529 CREM 0.55 7.4 0.38 1.17e-12 Inflammatory bowel disease;Crohn's disease; CRC cis rs12594515 1.000 rs12911309 chr15:45985719 G/C cg22117107 chr15:45993392 NA -0.44 -8.88 -0.44 4.52e-17 Waist circumference;Weight; CRC cis rs61774743 0.557 rs4359027 chr1:41848296 G/A cg00290994 chr1:41848739 NA 0.56 8.37 0.42 1.66e-15 Intelligence (multi-trait analysis); CRC cis rs11098499 0.863 rs10034450 chr4:120455649 A/G cg24375607 chr4:120327624 NA 0.47 7.05 0.36 1.06e-11 Corneal astigmatism; CRC cis rs875971 0.964 rs11765965 chr7:65842221 A/G cg00343986 chr7:65444356 GUSB 0.43 6.3 0.33 9.66e-10 Aortic root size; CRC cis rs7617773 0.539 rs13069884 chr3:48381148 T/A cg11946769 chr3:48343235 NME6 0.6 8.14 0.41 8.14e-15 Coronary artery disease; CRC trans rs12478296 1.000 rs56387669 chr2:243043889 T/C cg18288967 chr1:45987694 PRDX1 0.68 7.43 0.38 9.51e-13 Obesity-related traits; CRC trans rs9784649 0.641 rs72755823 chr5:25075537 T/C cg11038491 chr20:34638489 LOC647979 -0.69 -8.24 -0.41 4.17e-15 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs6912958 0.967 rs9450688 chr6:88159276 T/C cg12350822 chr6:88032061 C6orf162;GJB7 -0.36 -6.89 -0.36 2.78e-11 Monocyte percentage of white cells; CRC cis rs875971 0.862 rs28491091 chr7:65669064 G/T cg11764359 chr7:65958608 NA -0.58 -8.64 -0.43 2.54e-16 Aortic root size; CRC cis rs2836950 0.520 rs8130240 chr21:40538108 G/A cg17971929 chr21:40555470 PSMG1 -0.6 -8.86 -0.44 5.15e-17 Menarche (age at onset); CRC cis rs1570884 0.556 rs2146146 chr13:50170368 C/T cg02321871 chr13:50159138 RCBTB1 -0.43 -6.13 -0.32 2.5e-9 Sum basophil neutrophil counts;Sum neutrophil eosinophil counts;Neutrophil count;Myeloid white cell count;Granulocyte count; CRC cis rs9914544 1.000 rs67411574 chr17:18797337 A/G cg26306683 chr17:18585705 ZNF286B 0.49 7.0 0.36 1.47e-11 Educational attainment (years of education); CRC cis rs9303280 0.837 rs907092 chr17:37922259 A/G cg17344932 chr17:38183730 MED24;SNORD124 -0.36 -5.77 -0.3 1.81e-8 Self-reported allergy; CRC cis rs8141529 0.507 rs5762936 chr22:29381377 A/G cg15236460 chr22:30163365 UCRC;ZMAT5 0.5 5.63 0.3 3.78e-8 Lymphocyte counts; CRC cis rs4233802 1.000 rs4577299 chr2:151138798 A/C cg25300694 chr2:151184358 NA -0.95 -7.44 -0.38 8.95e-13 Plasma omega-3 polyunsaturated fatty acid levels (docosahexaenoic acid); CRC cis rs4654899 1.000 rs6700718 chr1:21299363 A/C cg02927042 chr1:21476669 EIF4G3 0.49 7.87 0.4 5.04e-14 Superior frontal gyrus grey matter volume; CRC trans rs11098499 0.789 rs1980024 chr4:120253047 C/T cg25214090 chr10:38739885 LOC399744 0.53 8.36 0.42 1.81e-15 Corneal astigmatism; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg03399598 chr4:174091002 GALNT7 0.51 7.31 0.37 2.05e-12 Response to antipsychotic treatment; CRC cis rs2795502 1.000 rs2795503 chr10:43347224 T/A cg27426351 chr10:43362370 NA -0.6 -7.16 -0.37 5.43e-12 Blood protein levels; CRC cis rs796364 0.951 rs11675980 chr2:201051150 A/G cg25936922 chr2:200820526 C2orf60;C2orf47 -0.65 -6.83 -0.35 4.19e-11 Schizophrenia; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg18153499 chr19:47142459 NA 0.38 6.25 0.33 1.29e-9 Liver disease severity in Alagille syndrome; CRC cis rs2404602 0.536 rs12915248 chr15:76765615 A/T cg23625390 chr15:77176239 SCAPER 0.4 5.77 0.3 1.84e-8 Blood metabolite levels; CRC trans rs6598955 0.671 rs12088858 chr1:26643708 C/A cg07461501 chr17:79650226 HGS;ARL16 -0.55 -6.45 -0.34 3.9e-10 Obesity-related traits; CRC cis rs4285028 0.747 rs11916169 chr3:121403211 A/G cg20356878 chr3:121714668 ILDR1 -0.42 -5.81 -0.31 1.47e-8 Multiple sclerosis; CRC cis rs4680 1.000 rs4633 chr22:19950235 C/T cg06346307 chr22:19949965 COMT 0.25 6.15 0.32 2.19e-9 Blood metabolite levels; CRC trans rs10983614 1.000 rs7867776 chr9:120072627 A/G cg05095774 chr18:52495848 RAB27B 0.44 6.27 0.33 1.13e-9 Survival in pancreatic cancer; CRC cis rs1401999 1.000 rs2313217 chr3:183635997 A/G cg01324343 chr3:183735012 ABCC5 0.81 14.49 0.62 3.72e-37 Anterior chamber depth; CRC cis rs1545257 0.537 rs11125583 chr2:24646278 C/A cg06627628 chr2:24431161 ITSN2 -0.48 -7.1 -0.36 7.7e-12 Sjögren's syndrome; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg19193201 chr18:30050907 FAM59A 0.49 8.44 0.42 1.05e-15 Liver disease severity in Alagille syndrome; CRC cis rs4555082 0.874 rs2816611 chr14:105722976 G/C cg18132624 chr14:105716052 BTBD6;BRF1 -0.46 -7.37 -0.38 1.44e-12 Mean platelet volume;Platelet distribution width; CRC cis rs950169 0.723 rs17589320 chr15:84919996 C/A cg17507749 chr15:85114479 UBE2QP1 0.75 10.99 0.52 3.83e-24 Schizophrenia; CRC trans rs9341835 0.740 rs7763834 chr6:64149357 T/C cg13657004 chr13:50234944 EBPL -0.37 -6.18 -0.32 1.91e-9 Schizophrenia; CRC cis rs4566357 0.615 rs10184991 chr2:227916533 G/A cg11843606 chr2:227700838 RHBDD1 -0.44 -6.85 -0.35 3.65e-11 Coronary artery disease; CRC cis rs12190007 0.517 rs3006210 chr6:169828915 C/T cg15038512 chr6:170123185 PHF10 -0.4 -6.15 -0.32 2.28e-9 Obesity-related traits; CRC cis rs7772486 0.754 rs9497434 chr6:146260753 C/T cg23711669 chr6:146136114 FBXO30 -0.72 -12.62 -0.57 4.76e-30 Lobe attachment (rater-scored or self-reported); CRC cis rs10504229 1.000 rs67913746 chr8:58177825 A/G cg24829409 chr8:58192753 C8orf71 -0.68 -11.34 -0.53 2.27e-25 Developmental language disorder (linguistic errors); CRC cis rs34779708 0.931 rs2384275 chr10:35297142 A/G cg03585969 chr10:35415529 CREM 0.62 8.44 0.42 1.01e-15 Inflammatory bowel disease;Crohn's disease; CRC cis rs2404602 0.618 rs12442266 chr15:76567142 T/C cg00316803 chr15:76480434 C15orf27 -0.39 -6.67 -0.35 1.05e-10 Blood metabolite levels; CRC cis rs6835098 1.000 rs10027708 chr4:174083116 T/C cg08422745 chr4:174089978 GALNT7 -0.94 -15.47 -0.65 5.96e-41 Dementia and core Alzheimer's disease neuropathologic changes; CRC cis rs6951245 1.000 rs11761941 chr7:1097183 G/A cg18402987 chr7:1209562 NA 0.67 7.17 0.37 5.02e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs2882667 0.898 rs4380651 chr5:138391072 A/G cg04439458 chr5:138467593 SIL1 -0.31 -5.61 -0.3 4.19e-8 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs6502050 0.835 rs34287733 chr17:80078236 C/T cg11859384 chr17:80120422 CCDC57 0.38 5.88 0.31 1.01e-8 Life satisfaction; CRC cis rs4665809 0.838 rs7565843 chr2:26292912 G/C cg26119090 chr2:26468346 HADHA;HADHB -0.61 -7.87 -0.4 5.22e-14 Gut microbiome composition (summer); CRC cis rs6921919 0.638 rs9468344 chr6:28309569 A/C cg06470822 chr6:28175283 NA 0.46 6.16 0.32 2.07e-9 Autism spectrum disorder or schizophrenia; CRC cis rs6121246 0.542 rs2376990 chr20:30238744 G/A cg13852791 chr20:30311386 BCL2L1 0.63 9.68 0.47 1.13e-19 Mean corpuscular hemoglobin; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg23844497 chr19:56135921 ZNF784 0.43 6.19 0.32 1.8e-9 Intelligence (multi-trait analysis); CRC cis rs3924048 0.574 rs11121928 chr1:12615888 C/G cg23650765 chr1:12612165 NA 0.36 7.18 0.37 4.58e-12 Optic cup area; CRC cis rs4713118 0.513 rs149878 chr6:27878738 T/G cg12273811 chr6:28175739 NA 0.59 8.66 0.43 2.15e-16 Parkinson's disease; CRC cis rs1506636 1.000 rs2429616 chr7:123406034 C/T cg03229431 chr7:123269106 ASB15 0.73 11.66 0.54 1.6e-26 Plateletcrit;Platelet count; CRC cis rs3741404 0.791 rs2282491 chr11:63918373 T/C cg19465662 chr11:63993652 NUDT22;TRPT1 0.85 14.12 0.61 1e-35 Platelet count; CRC cis rs7811142 0.830 rs11765869 chr7:99964789 T/G cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.09 14.62 0.63 1.22e-37 Platelet count; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg23098599 chr19:15235953 ILVBL 0.39 6.16 0.32 2.08e-9 Intelligence (multi-trait analysis); CRC cis rs801193 0.660 rs1016265 chr7:66214567 C/T cg18912574 chr7:65842487 NCRNA00174 0.35 5.9 0.31 8.96e-9 Aortic root size; CRC cis rs57221529 0.563 rs4957057 chr5:569230 C/G cg14541582 chr5:601475 NA -0.27 -5.76 -0.3 1.98e-8 Lung disease severity in cystic fibrosis; CRC cis rs11864453 1.000 rs7201491 chr16:72034312 G/A cg23815491 chr16:72088622 HP 0.56 8.52 0.43 5.92e-16 Fibrinogen levels; CRC cis rs7666738 0.791 rs2865958 chr4:99040732 G/T cg17366294 chr4:99064904 C4orf37 0.44 7.5 0.38 6.02e-13 Colonoscopy-negative controls vs population controls; CRC cis rs1336900 0.544 rs10888386 chr1:150611957 A/G cg15448220 chr1:150897856 SETDB1 -0.45 -6.25 -0.33 1.31e-9 Blood protein levels; CRC cis rs897984 0.645 rs9938550 chr16:30999142 A/G cg02466173 chr16:30829666 NA 0.61 9.21 0.45 3.86e-18 Dementia with Lewy bodies; CRC trans rs80264589 1 rs80264589 chr6:26927602 G/A cg06606381 chr12:133084897 FBRSL1 -0.97 -6.93 -0.36 2.18e-11 Lung cancer;Intelligence (multi-trait analysis); CRC cis rs6479527 0.875 rs3996241 chr9:96768979 G/T cg14459158 chr9:96720562 NA 0.4 7.11 0.36 7.37e-12 Esophageal adenocarcinoma; CRC cis rs4253772 0.550 rs6008598 chr22:46704243 C/T cg24881330 chr22:46731750 TRMU 0.63 7.11 0.36 7.28e-12 LDL cholesterol;Cholesterol, total; CRC cis rs4664293 0.867 rs34893664 chr2:160588777 T/A cg08347373 chr2:160653686 CD302 -0.47 -7.43 -0.38 9.32e-13 Monocyte percentage of white cells; CRC cis rs4594175 0.926 rs4617765 chr14:51598843 T/C cg23942311 chr14:51606299 NA 0.67 11.22 0.53 5.87e-25 Cancer; CRC cis rs4908768 0.539 rs1934138 chr1:8645816 G/A cg20416874 chr1:8611966 RERE -0.42 -6.04 -0.32 4.27e-9 Neuroticism (multi-trait analysis);Subjective well-being (multi-trait analysis); CRC cis rs972578 0.967 rs4822235 chr22:43338090 T/C cg01576275 chr22:43409880 NA -0.47 -7.65 -0.39 2.29e-13 Mean platelet volume; CRC cis rs1008375 0.932 rs2302394 chr4:17641188 A/G cg16339924 chr4:17578868 LAP3 0.58 7.31 0.37 2.06e-12 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs72781680 0.716 rs2712061 chr2:24026411 G/A cg08917208 chr2:24149416 ATAD2B 0.53 6.36 0.33 6.58e-10 Lymphocyte counts; CRC cis rs6502050 0.865 rs8079388 chr17:80162798 C/A cg19223190 chr17:80058835 NA 0.42 6.79 0.35 5.1e-11 Life satisfaction; CRC cis rs9660992 0.573 rs1172139 chr1:205213962 G/A cg00857998 chr1:205179979 DSTYK 0.43 5.71 0.3 2.57e-8 Mean corpuscular volume;Mean platelet volume; CRC cis rs9400239 0.622 rs1268171 chr6:109007304 C/G cg11073813 chr6:109029018 NA -0.4 -6.33 -0.33 7.89e-10 Waist circumference;Body mass index;BMI (adjusted for smoking behaviour); CRC cis rs41005 1.000 rs42357 chr2:8110896 C/T cg03155496 chr2:8117019 LOC339788 0.4 7.12 0.37 6.88e-12 Response to anti-TNF therapy in rheumatoid arthritis; CRC cis rs7811142 1.000 rs4472444 chr7:100070758 T/C cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.75 10.37 0.5 5.39e-22 Platelet count; CRC cis rs35110281 0.807 rs6518301 chr21:45016818 T/C cg01579765 chr21:45077557 HSF2BP -0.36 -6.86 -0.35 3.52e-11 Mean corpuscular volume; CRC cis rs910316 1.000 rs175492 chr14:75545220 A/C cg03030879 chr14:75389066 RPS6KL1 -0.45 -7.27 -0.37 2.62e-12 Height; CRC cis rs6951245 1.000 rs80031817 chr7:1096793 T/C cg07217954 chr7:1067459 C7orf50 0.55 5.72 0.3 2.36e-8 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs7945705 0.747 rs1980429 chr11:9010474 C/A cg12365402 chr11:9010492 NRIP3 -0.62 -11.6 -0.54 2.69e-26 Hemoglobin concentration; CRC cis rs7223966 0.921 rs67018565 chr17:61928055 C/A cg05941027 chr17:61774174 LIMD2 0.34 6.06 0.32 3.68e-9 Hip circumference adjusted for BMI;Body mass index; CRC cis rs1707322 0.663 rs3935296 chr1:46180470 T/C cg06784218 chr1:46089804 CCDC17 -0.66 -12.27 -0.56 9.04e-29 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs55823223 0.564 rs936396 chr17:73846829 C/G cg24416660 chr17:73865998 NA -0.38 -5.74 -0.3 2.1e-8 Psoriasis; CRC cis rs2976388 0.556 rs4736321 chr8:143822194 C/T cg05569086 chr8:143859399 LYNX1 -0.39 -6.06 -0.32 3.81e-9 Urinary tract infection frequency; CRC cis rs2549003 1.000 rs2549004 chr5:131827825 C/G cg02551604 chr5:131831745 NA 0.56 8.65 0.43 2.31e-16 Asthma (sex interaction); CRC cis rs6960043 0.875 rs6976381 chr7:15048814 T/C cg19272540 chr7:15055459 NA -0.23 -5.86 -0.31 1.12e-8 Type 2 diabetes; CRC cis rs9430161 0.579 rs9659356 chr1:11034817 A/G cg02454025 chr1:11042201 C1orf127 1.02 18.42 0.71 1.38e-52 Ewing sarcoma; CRC cis rs6988985 0.728 rs7003319 chr8:143954747 T/C cg10324643 chr8:143916377 GML 0.35 5.8 0.3 1.53e-8 Plasma androstenedione levels in resected early stage-receptor positive breast cancer; CRC cis rs1401999 0.966 rs1533682 chr3:183634879 A/G cg01324343 chr3:183735012 ABCC5 0.82 15.09 0.64 1.79e-39 Anterior chamber depth; CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg08306513 chr11:120040083 NA -0.5 -6.21 -0.32 1.57e-9 Diisocyanate-induced asthma; CRC cis rs9648716 0.810 rs6944039 chr7:140584017 A/T cg10747023 chr7:140774559 NA 0.44 5.88 0.31 9.82e-9 Type 2 diabetes; CRC cis rs10504229 0.817 rs114173899 chr8:58170640 G/T cg02290350 chr8:58132656 NA -0.42 -5.94 -0.31 7.42e-9 Developmental language disorder (linguistic errors); CRC cis rs968567 0.705 rs174573 chr11:61600327 G/A cg06781209 chr11:61594997 FADS2 -0.57 -8.0 -0.4 2.11e-14 Blood metabolite levels;Rheumatoid arthritis;Vitiligo;Glycerophospholipid levels; CRC cis rs8044868 0.530 rs7940 chr16:72146441 C/G cg23815491 chr16:72088622 HP 0.49 7.1 0.36 7.56e-12 Body mass index (change over time) in cancer or chronic obstructive pulmonary disease;Body mass index (change over time) in cancer; CRC cis rs10504229 1.000 rs17217082 chr8:58180918 G/A cg01721255 chr8:58191610 C8orf71 0.49 6.17 0.32 2e-9 Developmental language disorder (linguistic errors); CRC cis rs17711722 1.000 rs17711722 chr7:65271197 C/T cg18912574 chr7:65842487 NCRNA00174 -0.33 -5.62 -0.3 4.18e-8 Calcium levels; CRC cis rs877282 0.947 rs7904978 chr10:768078 C/T cg06581033 chr10:766294 NA -0.52 -5.77 -0.3 1.84e-8 Uric acid levels; CRC cis rs1448094 0.556 rs11611968 chr12:86168022 G/A cg00310523 chr12:86230176 RASSF9 0.4 6.52 0.34 2.7e-10 Major depressive disorder; CRC trans rs35110281 0.748 rs2838324 chr21:44999820 T/C cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.52 8.71 0.43 1.55e-16 Mean corpuscular volume; CRC cis rs734999 0.505 rs10910107 chr1:2539181 C/T cg18854424 chr1:2615690 NA 0.49 9.8 0.48 4.76e-20 Ulcerative colitis; CRC cis rs13202913 0.837 rs9397054 chr6:151789912 C/T cg10883421 chr6:151773342 RMND1;C6orf211 0.55 5.74 0.3 2.2e-8 Epstein-Barr virus copy number in lymphoblastoid cell lines; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg26505074 chr22:31477182 SMTN 0.5 7.32 0.37 1.92e-12 Intelligence (multi-trait analysis); CRC cis rs7786808 0.705 rs1377373 chr7:158215549 A/C cg15440763 chr7:158190612 PTPRN2 -0.41 -6.97 -0.36 1.71e-11 Obesity-related traits; CRC cis rs7591163 0.883 rs11891398 chr2:228723357 C/T cg21577049 chr2:228736449 WDR69 -0.44 -5.91 -0.31 8.7e-9 Blood pressure; CRC cis rs4555082 0.957 rs2816622 chr14:105733114 T/C cg18132624 chr14:105716052 BTBD6;BRF1 -0.43 -7.09 -0.36 8e-12 Mean platelet volume;Platelet distribution width; CRC cis rs853679 0.517 rs9283884 chr6:28135660 C/G cg15845792 chr6:28175446 NA -1.02 -13.3 -0.59 1.4e-32 Depression; CRC cis rs4970988 0.787 rs1532770 chr1:150725335 G/T cg18016565 chr1:150552671 MCL1 0.42 5.8 0.3 1.57e-8 Urate levels; CRC cis rs6772849 0.930 rs7639400 chr3:128323356 T/C cg08795948 chr3:128337044 NA 0.35 5.77 0.3 1.83e-8 Monocyte percentage of white cells;Monocyte count; CRC cis rs10504229 1.000 rs58382845 chr8:58169851 A/C cg02290350 chr8:58132656 NA -0.41 -5.74 -0.3 2.21e-8 Developmental language disorder (linguistic errors); CRC cis rs10927875 0.631 rs28579893 chr1:16347534 A/G cg10494257 chr1:16342123 HSPB7 0.44 5.75 0.3 2.02e-8 Dilated cardiomyopathy; CRC cis rs3785574 0.962 rs57553639 chr17:61848499 C/T cg25654072 chr17:61904446 PSMC5;FTSJ3 0.42 5.88 0.31 1.01e-8 Height; CRC cis rs11112613 0.713 rs12307351 chr12:105955634 T/A cg03607813 chr12:105948248 NA 0.8 10.45 0.5 2.88e-22 Corrected insulin response;Corrected insulin response adjusted for insulin sensitivity index; CRC cis rs17253792 0.818 rs78393484 chr14:56065802 T/C cg01858014 chr14:56050164 KTN1 -0.85 -6.69 -0.35 9.81e-11 Putamen volume; CRC cis rs1048238 0.506 rs6668183 chr1:16173814 G/C cg21385522 chr1:16154831 NA 0.61 9.05 0.45 1.28e-17 Systolic blood pressure; CRC cis rs243505 0.762 rs10225300 chr7:148502007 G/C cg09806900 chr7:148480153 CUL1 0.52 7.48 0.38 6.69e-13 Inflammatory bowel disease;Crohn's disease; CRC cis rs875971 0.830 rs1167406 chr7:65556936 G/C cg18876405 chr7:65276391 NA -0.51 -8.49 -0.42 6.96e-16 Aortic root size; CRC cis rs10504229 0.953 rs75253516 chr8:58171547 C/A cg24829409 chr8:58192753 C8orf71 -0.67 -10.85 -0.51 1.2e-23 Developmental language disorder (linguistic errors); CRC cis rs9303401 0.659 rs62083410 chr17:56964386 T/C cg02118635 chr17:56770003 RAD51C;TEX14 0.78 9.94 0.48 1.59e-20 Cognitive test performance; CRC cis rs4731207 0.619 rs4461840 chr7:124581065 A/T cg23710748 chr7:124431027 NA -0.38 -6.09 -0.32 3.18e-9 Cutaneous malignant melanoma; CRC cis rs1552244 0.832 rs115415687 chr3:10195704 C/T cg18598329 chr3:10140678 FANCD2;C3orf24 -0.8 -9.04 -0.45 1.41e-17 Alzheimer's disease; CRC trans rs12478296 0.681 rs56357900 chr2:243033966 A/C cg18288967 chr1:45987694 PRDX1 0.68 7.52 0.38 5.32e-13 Obesity-related traits; CRC cis rs9322193 0.847 rs12191643 chr6:149950048 C/T cg00933542 chr6:150070202 PCMT1 0.32 6.53 0.34 2.54e-10 Lung cancer; CRC cis rs9549367 0.713 rs3024746 chr13:113821777 G/A cg18105134 chr13:113819100 PROZ -0.86 -13.34 -0.59 9.22e-33 Platelet distribution width; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg17128646 chr2:198363565 HSPD1;HSPE1 0.42 6.17 0.32 1.98e-9 Intelligence (multi-trait analysis); CRC cis rs1552244 0.935 rs35148833 chr3:10116937 C/A cg08888203 chr3:10149979 C3orf24 0.73 10.16 0.49 2.86e-21 Alzheimer's disease; CRC cis rs3096299 0.658 rs4291902 chr16:89560315 G/C cg00750074 chr16:89608354 SPG7 -0.46 -6.95 -0.36 1.91e-11 Multiple myeloma (IgH translocation); CRC cis rs853679 0.882 rs9380064 chr6:28143118 A/G cg15845792 chr6:28175446 NA 0.8 6.4 0.33 5.31e-10 Depression; CRC cis rs881375 0.967 rs7046108 chr9:123660339 A/G cg09419670 chr9:123605666 PSMD5;LOC253039 -0.58 -8.34 -0.42 2.1e-15 Rheumatoid arthritis; CRC cis rs796364 0.806 rs1106400 chr2:201004089 T/C cg25936922 chr2:200820526 C2orf60;C2orf47 -0.57 -5.67 -0.3 3.07e-8 Schizophrenia; CRC trans rs561341 0.883 rs7406056 chr17:30220224 C/T cg27661571 chr11:113659931 NA -0.64 -7.36 -0.38 1.44e-12 Hip circumference adjusted for BMI; CRC cis rs13064411 0.542 rs9846539 chr3:113228688 A/G cg18753928 chr3:113234510 CCDC52 -0.52 -7.94 -0.4 3.18e-14 Response to simvastatin treatment (PCSK9 protein level change); CRC cis rs1008375 0.966 rs2872957 chr4:17651757 C/A cg04450456 chr4:17643702 FAM184B 0.37 5.88 0.31 9.91e-9 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs4319547 0.656 rs4997380 chr12:122838956 A/G cg05707623 chr12:122985044 ZCCHC8 -0.6 -7.42 -0.38 1e-12 Body mass index; CRC trans rs4130344 0.555 rs7664271 chr4:159865915 C/G cg04008429 chr3:160167646 TRIM59 0.4 6.05 0.32 3.86e-9 Intelligence (multi-trait analysis); CRC cis rs6701037 0.625 rs72719370 chr1:175128536 G/C cg14847009 chr1:175162515 KIAA0040 -0.27 -5.85 -0.31 1.21e-8 Alcohol dependence; CRC cis rs10206020 0.885 rs11899557 chr2:1576123 G/T cg12573674 chr2:1569213 NA -0.78 -10.53 -0.5 1.54e-22 IgG glycosylation; CRC cis rs6840360 0.642 rs1470281 chr4:152431552 A/G cg09659197 chr4:152720779 NA 0.34 6.68 0.35 1.05e-10 Intelligence (multi-trait analysis); CRC cis rs919433 1.000 rs2195510 chr2:198161195 A/G cg20885578 chr2:198174922 NA -0.37 -6.45 -0.34 3.91e-10 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC cis rs7085104 0.684 rs7092690 chr10:104609365 T/C cg15744005 chr10:104629667 AS3MT -0.37 -7.72 -0.39 1.45e-13 Immature fraction of reticulocytes;Schizophrenia; CRC cis rs6952808 0.723 rs11766575 chr7:2005747 T/C cg21782813 chr7:2030301 MAD1L1 0.52 8.88 0.44 4.47e-17 Bipolar disorder and schizophrenia; CRC cis rs2304069 0.545 rs1864998 chr5:149389465 C/T cg12661370 chr5:149340060 SLC26A2 0.43 6.19 0.32 1.8e-9 HIV-1 control; CRC cis rs6540559 1.000 rs2235372 chr1:209960436 A/G cg22029157 chr1:209979665 IRF6 -0.7 -9.98 -0.48 1.16e-20 Cleft lip with or without cleft palate; CRC trans rs208520 0.690 rs207740 chr6:66764132 T/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 1.04 14.61 0.63 1.29e-37 Exhaled nitric oxide output; CRC cis rs9549260 0.683 rs4941988 chr13:41196006 T/G cg21288729 chr13:41239152 FOXO1 0.42 6.59 0.34 1.8e-10 Red blood cell count; CRC cis rs55702914 0.652 rs12151726 chr2:198273591 C/T cg10820045 chr2:198174542 NA 0.38 6.65 0.34 1.19e-10 Major depression and alcohol dependence; CRC trans rs61931739 0.500 rs11053207 chr12:34459827 A/G cg13010199 chr12:38710504 ALG10B 0.46 6.5 0.34 3.07e-10 Morning vs. evening chronotype; CRC cis rs7216064 0.953 rs4790981 chr17:65921834 A/G cg12091567 chr17:66097778 LOC651250 -0.64 -8.04 -0.41 1.61e-14 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CRC trans rs11098499 0.863 rs12508173 chr4:120318526 T/C cg25214090 chr10:38739885 LOC399744 0.65 10.36 0.5 6.04e-22 Corneal astigmatism; CRC cis rs10504229 0.679 rs75402323 chr8:58136227 A/G cg02725872 chr8:58115012 NA -0.64 -11.55 -0.54 3.85e-26 Developmental language disorder (linguistic errors); CRC cis rs2075371 0.637 rs2544165 chr7:133920443 A/G cg20476274 chr7:133979776 SLC35B4 -0.74 -12.37 -0.56 4.1e-29 Mean platelet volume; CRC cis rs2836974 0.899 rs6517514 chr21:40527095 G/T cg11644478 chr21:40555479 PSMG1 0.82 13.39 0.59 6.26e-33 Cognitive function; CRC cis rs951366 0.764 rs823143 chr1:205743425 A/C cg24503407 chr1:205819492 PM20D1 0.83 13.04 0.58 1.3e-31 Menarche (age at onset); CRC cis rs7107174 1.000 rs2512550 chr11:77943848 C/T cg02023728 chr11:77925099 USP35 0.5 8.3 0.42 2.68e-15 Testicular germ cell tumor; CRC cis rs2180341 0.618 rs4502958 chr6:127593113 G/A cg27446573 chr6:127587934 RNF146 0.62 9.35 0.46 1.43e-18 Breast cancer; CRC cis rs2019137 0.539 rs6755040 chr2:113981137 T/C cg19083407 chr2:113993142 PAX8;LOC440839;LOC654433 0.59 8.88 0.44 4.57e-17 Lymphocyte counts; CRC cis rs6502050 0.835 rs4789675 chr17:80123144 G/A cg02741985 chr17:80059408 CCDC57 0.43 7.15 0.37 5.59e-12 Life satisfaction; CRC cis rs6582630 0.516 rs12814528 chr12:38296111 G/A cg26384229 chr12:38710491 ALG10B -0.52 -7.48 -0.38 6.83e-13 Drug-induced liver injury (flucloxacillin); CRC cis rs9309711 0.736 rs9309717 chr2:3495078 C/T cg10845886 chr2:3471009 TTC15 0.56 8.56 0.43 4.54e-16 Neurofibrillary tangles; CRC cis rs10504229 0.775 rs17805110 chr8:58161439 C/G cg22535103 chr8:58192502 C8orf71 0.69 8.32 0.42 2.45e-15 Developmental language disorder (linguistic errors); CRC cis rs8067545 0.611 rs7219908 chr17:20043036 A/G cg13482628 chr17:19912719 NA 0.43 6.75 0.35 6.5500000000000006e-11 Schizophrenia; CRC cis rs67311347 0.956 rs7640228 chr3:40516190 G/A cg24209194 chr3:40518798 ZNF619 -0.41 -6.04 -0.32 4.07e-9 Renal cell carcinoma; CRC cis rs644799 1.000 rs7749 chr11:95565789 G/A cg03916912 chr11:95522834 CEP57;FAM76B 0.95 18.45 0.71 1.09e-52 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs7666738 0.924 rs11097592 chr4:98927532 C/T cg17366294 chr4:99064904 C4orf37 0.48 7.63 0.39 2.5e-13 Colonoscopy-negative controls vs population controls; CRC cis rs1448094 0.510 rs1993806 chr12:86147151 T/C cg02569458 chr12:86230093 RASSF9 -0.48 -8.08 -0.41 1.27e-14 Major depressive disorder; CRC cis rs3091242 0.935 rs4233043 chr1:25765483 A/G cg23205692 chr1:25664452 TMEM50A 0.42 5.92 0.31 8.01e-9 Erythrocyte sedimentation rate; CRC cis rs6460942 0.591 rs10262667 chr7:12385391 C/T cg20607287 chr7:12443886 VWDE -0.53 -7.18 -0.37 4.53e-12 Coronary artery disease; CRC cis rs7552404 1.000 rs4646961 chr1:76217169 G/A cg03433033 chr1:76189801 ACADM 0.81 11.15 0.52 1.08e-24 Blood metabolite levels;Acylcarnitine levels; CRC cis rs7524258 0.835 rs7543228 chr1:7306538 G/C cg07173049 chr1:7289937 CAMTA1 0.56 8.95 0.44 2.72e-17 Tourette's syndrome or obsessive-compulsive disorder; CRC cis rs9487051 1.000 rs6568569 chr6:109613196 C/A cg01475377 chr6:109611718 NA -0.45 -8.11 -0.41 9.88e-15 Reticulocyte fraction of red cells; CRC cis rs12477438 0.520 rs11677247 chr2:99756358 A/G cg14399236 chr2:99771627 LIPT1;TSGA10 0.82 14.44 0.62 5.96e-37 Chronic sinus infection; CRC cis rs11212617 0.967 rs11212635 chr11:108310702 T/A cg12106634 chr11:108092400 ATM;NPAT -0.39 -5.68 -0.3 2.96e-8 Response to metformin in type 2 diabetes (glycemic); CRC cis rs3126085 0.877 rs4456097 chr1:152229741 G/A cg09127314 chr1:152161683 NA 0.47 5.99 0.31 5.61e-9 Atopic dermatitis; CRC cis rs17711722 0.522 rs6957759 chr7:65271785 A/G cg18876405 chr7:65276391 NA 0.54 9.11 0.45 8.09e-18 Calcium levels; CRC trans rs3733585 0.664 rs17185870 chr4:9958214 C/A cg26043149 chr18:55253948 FECH -0.5 -7.65 -0.39 2.29e-13 Cleft plate (environmental tobacco smoke interaction); CRC cis rs853679 1.000 rs1778508 chr6:28229881 C/T cg15845792 chr6:28175446 NA -0.58 -6.04 -0.32 4.15e-9 Depression; CRC cis rs7769051 0.522 rs6934155 chr6:133124021 C/T cg22852734 chr6:133119734 C6orf192 1.12 8.39 0.42 1.43e-15 Type 2 diabetes nephropathy; CRC trans rs1005277 0.579 rs1740735 chr10:38497777 A/C cg11292332 chr7:45801988 SEPT13 -0.38 -6.95 -0.36 1.93e-11 Extrinsic epigenetic age acceleration; CRC cis rs77106637 0.932 rs2886599 chr11:72721271 C/A cg03713592 chr11:72463424 ARAP1 0.82 7.5 0.38 6.11e-13 Type 2 diabetes; CRC cis rs902774 0.818 rs55958994 chr12:53301019 C/T cg16329197 chr12:53359506 NA -0.55 -6.0 -0.31 5.27e-9 Prostate cancer; CRC cis rs2976388 0.566 rs2585141 chr8:143806343 G/A cg15511327 chr8:143859410 LYNX1 -0.43 -7.22 -0.37 3.69e-12 Urinary tract infection frequency; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg07355693 chr12:125667907 NA 0.47 7.22 0.37 3.62e-12 Intelligence (multi-trait analysis); CRC cis rs523522 0.962 rs4767903 chr12:120930046 G/A cg27279351 chr12:120934652 DYNLL1 0.75 11.46 0.53 8.32e-26 High light scatter reticulocyte count; CRC cis rs1949733 0.598 rs55765509 chr4:8532732 T/A cg11789530 chr4:8429930 ACOX3 -0.61 -8.26 -0.41 3.65e-15 Response to antineoplastic agents; CRC cis rs2652834 1.000 rs2652832 chr15:63396928 T/C cg05507819 chr15:63340323 TPM1 0.46 5.98 0.31 5.96e-9 HDL cholesterol; CRC cis rs3823572 0.525 rs4546584 chr7:133704270 A/C cg03336402 chr7:133662267 EXOC4 0.66 9.56 0.47 2.87e-19 Intelligence (multi-trait analysis); CRC trans rs2727020 0.595 rs10769583 chr11:49483193 G/A cg03929089 chr4:120376271 NA -0.91 -17.23 -0.69 7.51e-48 Coronary artery disease; CRC cis rs9517320 0.534 rs3825430 chr13:99129653 C/T cg20487152 chr13:99095054 FARP1 -0.45 -6.44 -0.33 4.33e-10 Longevity; CRC cis rs10751667 0.600 rs11246377 chr11:999796 G/T ch.11.42038R chr11:967971 AP2A2 0.55 8.83 0.44 6.37e-17 Alzheimer's disease (late onset); CRC cis rs10504229 0.683 rs949856 chr8:58144496 G/A cg05313129 chr8:58192883 C8orf71 -0.43 -6.1 -0.32 3.06e-9 Developmental language disorder (linguistic errors); CRC cis rs7618915 0.547 rs33967311 chr3:52683864 G/T cg07507251 chr3:52567010 NT5DC2 0.41 5.87 0.31 1.04e-8 Bipolar disorder; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg04068910 chr10:101989347 CHUK 0.42 6.21 0.32 1.61e-9 Intelligence (multi-trait analysis); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg14862950 chr11:66112661 BRMS1 0.45 6.29 0.33 1.01e-9 Response to antipsychotic treatment; CRC cis rs6840360 0.615 rs12503677 chr4:152610543 A/G cg09659197 chr4:152720779 NA 0.42 8.45 0.42 9.24e-16 Intelligence (multi-trait analysis); CRC cis rs1670533 1.000 rs6858612 chr4:1053353 C/T cg27284194 chr4:1044797 NA 0.51 6.48 0.34 3.41e-10 Recombination rate (females); CRC cis rs4363385 0.818 rs11205175 chr1:153001296 A/C cg25856811 chr1:152973957 SPRR3 -0.26 -7.22 -0.37 3.71e-12 Inflammatory skin disease; CRC cis rs1552244 0.882 rs13088350 chr3:10044626 T/C cg13047869 chr3:10149882 C3orf24 0.51 6.97 0.36 1.74e-11 Alzheimer's disease; CRC cis rs6088590 0.502 rs6059861 chr20:33068563 A/T cg08999081 chr20:33150536 PIGU 0.61 11.42 0.53 1.15e-25 Coronary artery disease; CRC cis rs3806843 0.648 rs702399 chr5:140024432 C/T cg19875535 chr5:140030758 IK -0.64 -11.02 -0.52 3.12e-24 Depressive symptoms (multi-trait analysis); CRC cis rs2404602 0.552 rs4886823 chr15:76965402 A/G cg23625390 chr15:77176239 SCAPER -0.75 -10.77 -0.51 2.35e-23 Blood metabolite levels; CRC cis rs447 0.767 rs1468344 chr7:83748890 A/G cg22846510 chr7:83753280 SEMA3A -0.42 -5.8 -0.3 1.53e-8 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs593982 1.000 rs1941746 chr11:65502413 A/G cg08755490 chr11:65554678 OVOL1 1.2 18.64 0.72 2.04e-53 Atopic dermatitis; CRC cis rs12200782 0.505 rs1535275 chr6:26520767 G/C cg09904177 chr6:26538194 HMGN4 0.55 6.54 0.34 2.41e-10 Small cell lung carcinoma; CRC cis rs7385804 0.633 rs221795 chr7:100283261 C/T cg16850897 chr7:100343110 ZAN 0.47 7.08 0.36 8.98e-12 Iron status biomarkers;Mean corpuscular hemoglobin;Hematocrit;Iron status biomarkers (transferrin saturation);Red blood cell count;Iron status biomarkers (iron levels);Mean corpuscular volume;Hematological parameters; CRC cis rs7918232 0.627 rs10829165 chr10:27319465 A/G cg14442939 chr10:27389572 ANKRD26 0.64 7.51 0.38 5.79e-13 Breast cancer; CRC cis rs11997175 0.624 rs4621768 chr8:33677452 T/C cg04338863 chr8:33670619 NA 0.44 7.06 0.36 9.65e-12 Body mass index; CRC cis rs738322 1.000 rs133009 chr22:38569653 G/C cg03162506 chr22:38580953 NA 0.26 5.69 0.3 2.77e-8 Cutaneous nevi; CRC cis rs9303280 0.806 rs12936409 chr17:38043649 C/T cg20243544 chr17:37824526 PNMT 0.38 5.71 0.3 2.5e-8 Self-reported allergy; CRC cis rs8072100 0.935 rs8070759 chr17:45638760 C/T cg25173405 chr17:45401733 C17orf57 0.44 6.83 0.35 4.14e-11 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs185694 0.779 rs609919 chr13:30895904 C/G cg07600127 chr13:30881527 KATNAL1 -0.52 -5.86 -0.31 1.15e-8 Antineutrophil cytoplasmic antibody-associated vasculitis; CRC cis rs2832191 0.791 rs7283853 chr21:30498515 G/A cg08807101 chr21:30365312 RNF160 -0.61 -9.53 -0.46 3.71e-19 Dental caries; CRC cis rs67385638 0.802 rs11036635 chr11:5308896 C/T cg21506790 chr11:5277210 HBG2 0.34 5.88 0.31 1.03e-8 Hemoglobin levels; CRC cis rs6951245 0.678 rs28600085 chr7:1169636 C/T cg03188948 chr7:1209495 NA 0.63 7.07 0.36 9.12e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs1348850 0.526 rs4893829 chr2:178399810 A/G cg27490568 chr2:178487706 NA -0.6 -7.47 -0.38 7.31e-13 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC trans rs10983614 1.000 rs7867776 chr9:120072627 A/G cg26801646 chr10:76970496 VDAC2 0.47 6.76 0.35 6.18e-11 Survival in pancreatic cancer; CRC cis rs7677751 0.806 rs6554163 chr4:55102559 A/T cg13615338 chr4:55094005 PDGFRA 0.4 6.0 0.31 5.14e-9 Corneal astigmatism; CRC cis rs447 1.000 rs3801655 chr7:83753335 C/G cg22846510 chr7:83753280 SEMA3A -0.6 -7.71 -0.39 1.51e-13 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs7131987 0.903 rs11050153 chr12:29405148 T/C cg09582351 chr12:29534625 ERGIC2 -0.27 -5.76 -0.3 1.94e-8 QT interval; CRC trans rs1005277 0.579 rs1548255 chr10:38417193 T/C cg23533926 chr12:111358616 MYL2 -0.53 -7.92 -0.4 3.58e-14 Extrinsic epigenetic age acceleration; CRC cis rs2836974 0.899 rs114399588 chr21:40653958 G/A cg06238570 chr21:40685208 BRWD1 0.76 10.36 0.5 5.88e-22 Cognitive function; CRC cis rs13108904 0.539 rs13145722 chr4:1338422 T/A cg20092199 chr4:1342459 KIAA1530 0.45 7.25 0.37 3.05e-12 Obesity-related traits; CRC cis rs2243480 1.000 rs34815098 chr7:65292254 A/C cg12463550 chr7:65579703 CRCP 0.67 6.15 0.32 2.2e-9 Diabetic kidney disease; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg16599568 chr1:165567358 NA 0.53 7.78 0.39 9.59e-14 Response to antipsychotic treatment; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg15172729 chr11:67056446 ANKRD13D 0.41 6.45 0.34 4.03e-10 Intelligence (multi-trait analysis); CRC cis rs10504229 0.861 rs59873610 chr8:58172290 T/A cg01721255 chr8:58191610 C8orf71 0.49 6.17 0.32 2.06e-9 Developmental language disorder (linguistic errors); CRC cis rs7927592 0.731 rs7108376 chr11:68347870 A/G cg16797656 chr11:68205561 LRP5 -0.49 -8.95 -0.44 2.7e-17 Total body bone mineral density; CRC cis rs6499255 1.000 rs8045682 chr16:69786092 C/A cg00738113 chr16:70207722 CLEC18C -0.41 -5.93 -0.31 7.84e-9 IgE levels; CRC cis rs13108904 0.901 rs1680073 chr4:1280337 G/A cg15763984 chr4:1342303 KIAA1530 -0.35 -6.08 -0.32 3.29e-9 Obesity-related traits; CRC cis rs1552244 0.554 rs58020561 chr3:10054682 A/G cg00166722 chr3:10149974 C3orf24 0.43 6.32 0.33 8.43e-10 Alzheimer's disease; CRC trans rs1814175 0.817 rs4881623 chr11:49804991 C/T cg21153622 chr11:89784906 NA -0.37 -6.01 -0.31 4.99e-9 Height; CRC cis rs1577917 0.917 rs4707226 chr6:86527828 G/A cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.49 -6.58 -0.34 1.82e-10 Response to antipsychotic treatment; CRC cis rs35306767 0.715 rs17221456 chr10:1037234 T/C cg26597838 chr10:835615 NA 0.95 10.77 0.51 2.22e-23 Eosinophil percentage of granulocytes; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg15785704 chr17:30669010 C17orf75 0.42 5.96 0.31 6.38e-9 Response to antipsychotic treatment; CRC cis rs853679 0.517 rs67878650 chr6:28142587 G/C cg12172441 chr6:28176163 NA 0.63 7.43 0.38 9.41e-13 Depression; CRC trans rs7267979 1.000 rs2424716 chr20:25423538 G/A cg17903999 chr18:56338584 MALT1 -0.41 -6.71 -0.35 8.45e-11 Liver enzyme levels (alkaline phosphatase); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg20183778 chr7:102105344 ALKBH4;LRWD1 0.41 5.99 0.31 5.52e-9 Response to antipsychotic treatment; CRC cis rs9914988 1.000 rs901975 chr17:27189774 A/G cg12682573 chr17:27188876 MIR451;MIR144 -0.6 -8.94 -0.44 2.83e-17 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg18891615 chr8:101962925 YWHAZ 0.41 6.69 0.35 9.66e-11 Liver disease severity in Alagille syndrome; CRC trans rs208520 0.955 rs17644076 chr6:67004973 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.78 -9.56 -0.47 2.81e-19 Exhaled nitric oxide output; CRC cis rs4665809 0.941 rs1434079 chr2:26284670 C/G cg22920501 chr2:26401640 FAM59B -0.53 -7.23 -0.37 3.39e-12 Gut microbiome composition (summer); CRC cis rs2880765 0.835 rs4360874 chr15:86040820 A/T cg17133734 chr15:86042851 AKAP13 0.44 6.93 0.36 2.19e-11 Coronary artery disease; CRC cis rs7089973 0.872 rs7918253 chr10:116614501 T/C cg23260525 chr10:116636907 FAM160B1 0.31 6.65 0.34 1.23e-10 Bipolar disorder or attention deficit hyperactivity disorder; CRC cis rs1448094 0.533 rs10863078 chr12:86152672 C/T cg00310523 chr12:86230176 RASSF9 -0.38 -6.09 -0.32 3.19e-9 Major depressive disorder; CRC cis rs11190604 1.000 rs2273694 chr10:102256496 G/T cg16342193 chr10:102329863 NA -0.35 -5.68 -0.3 3.04e-8 Palmitoleic acid (16:1n-7) levels; CRC cis rs2760061 0.626 rs592736 chr1:228116831 A/G cg02753203 chr1:228287806 NA -0.6 -9.01 -0.44 1.76e-17 Diastolic blood pressure; CRC trans rs703108 0.731 rs7898954 chr10:22323646 A/G cg09455096 chr2:61765470 XPO1 -0.52 -5.97 -0.31 6.07e-9 Monocyte percentage of white cells; CRC trans rs9858542 0.953 rs11926781 chr3:49603289 C/T cg21665057 chr3:196295764 WDR53;FBXO45 -0.71 -9.56 -0.47 2.84e-19 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs6694672 1.000 rs4915309 chr1:197048781 A/T cg13682187 chr1:196946512 CFHR5 0.47 7.35 0.38 1.56e-12 Asthma; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg20769334 chr22:50913335 SBF1 0.4 6.57 0.34 1.97e-10 Liver disease severity in Alagille syndrome; CRC cis rs6089584 0.888 rs6061979 chr20:60617141 C/G cg18761221 chr20:60518478 NA 0.45 7.26 0.37 2.88e-12 Body mass index; CRC cis rs9814567 0.806 rs4955525 chr3:134317008 C/T cg06541857 chr3:134203789 ANAPC13;CEP63 -0.37 -5.67 -0.3 3.08e-8 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs6963495 0.606 rs6969426 chr7:105147150 G/A cg13798780 chr7:105162888 PUS7 0.66 8.06 0.41 1.39e-14 Bipolar disorder (body mass index interaction); CRC cis rs12586317 0.547 rs115019197 chr14:35503764 G/A cg16230307 chr14:35515116 FAM177A1 0.91 10.73 0.51 3.18e-23 Psoriasis; CRC trans rs2243480 1.000 rs6949812 chr7:65387101 G/A cg10756647 chr7:56101905 PSPH 0.73 8.07 0.41 1.36e-14 Diabetic kidney disease; CRC cis rs8177253 0.665 rs9869535 chr3:133451581 G/A cg24879335 chr3:133465180 TF 0.37 6.81 0.35 4.56e-11 Iron status biomarkers; CRC cis rs9527 0.571 rs4917985 chr10:104624072 C/T cg08772003 chr10:104629869 AS3MT -0.36 -5.95 -0.31 6.95e-9 Arsenic metabolism; CRC trans rs7395662 0.517 rs10454483 chr11:48754997 A/G cg15704280 chr7:45808275 SEPT13 -0.52 -7.54 -0.38 4.69e-13 HDL cholesterol; CRC cis rs9914988 0.943 rs12453504 chr17:27119524 C/A cg20469991 chr17:27169893 C17orf63 -0.6 -7.27 -0.37 2.59e-12 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs6951245 0.935 rs113365567 chr7:1108785 T/C cg18402987 chr7:1209562 NA 0.67 7.19 0.37 4.39e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs4785763 0.570 rs4785759 chr16:90050880 G/T cg05185784 chr16:90016020 DEF8 -0.53 -8.26 -0.41 3.72e-15 Melanoma; CRC cis rs6121246 0.559 rs6119652 chr20:30259445 C/G cg13852791 chr20:30311386 BCL2L1 0.71 13.8 0.61 1.74e-34 Mean corpuscular hemoglobin; CRC cis rs7216064 1.000 rs12602912 chr17:65870073 C/T cg12091567 chr17:66097778 LOC651250 -0.67 -7.79 -0.39 8.84e-14 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CRC cis rs6951245 1.000 rs77346188 chr7:1114023 C/A cg20603222 chr7:1096387 C7orf50;GPR146 -0.72 -8.6 -0.43 3.27e-16 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs6424115 0.729 rs561733 chr1:24049595 T/G cg15997130 chr1:24165203 NA 0.7 10.36 0.5 5.81e-22 Immature fraction of reticulocytes; CRC cis rs1552244 0.882 rs55840655 chr3:10042690 C/T cg02579736 chr3:10068473 FANCD2;CIDECP 0.93 12.04 0.55 6.69e-28 Alzheimer's disease; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg21998383 chr1:162039240 NOS1AP 0.44 6.25 0.33 1.29e-9 Response to antipsychotic treatment; CRC cis rs2832191 1.000 rs2832190 chr21:30488226 G/A cg24692254 chr21:30365293 RNF160 -0.65 -11.2 -0.53 7.06e-25 Dental caries; CRC cis rs2455601 1.000 rs11042114 chr11:8919889 C/T cg21881798 chr11:8931708 C11orf17;ST5 -0.55 -6.15 -0.32 2.27e-9 Schizophrenia; CRC cis rs56104184 0.725 rs4347731 chr19:49385154 A/G cg21252483 chr19:49399788 TULP2 -0.45 -6.11 -0.32 2.81e-9 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; CRC cis rs947211 0.846 rs823155 chr1:205762946 T/C cg14893161 chr1:205819251 PM20D1 0.47 6.87 0.35 3.27e-11 Parkinson's disease; CRC cis rs4660306 0.677 rs1691216 chr1:45899416 A/G cg03123370 chr1:45965343 CCDC163P;MMACHC 0.5 6.72 0.35 8.12e-11 Homocysteine levels; CRC cis rs72781680 0.848 rs72780199 chr2:24016269 A/C cg08917208 chr2:24149416 ATAD2B 0.84 8.11 0.41 1e-14 Lymphocyte counts; CRC cis rs1707322 1.000 rs1612419 chr1:46546945 T/C cg03146154 chr1:46216737 IPP -0.59 -8.06 -0.41 1.44e-14 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs10911251 0.508 rs729672 chr1:183109236 G/A ch.1.3577855R chr1:183094577 LAMC1 0.81 14.26 0.62 2.96e-36 Colorectal cancer; CRC cis rs8031584 0.958 rs1043742 chr15:31232581 A/C cg08109568 chr15:31115862 NA -0.51 -8.39 -0.42 1.49e-15 Huntington's disease progression; CRC cis rs920590 0.758 rs7011322 chr8:19661937 C/T cg03894339 chr8:19674705 INTS10 0.42 5.73 0.3 2.21e-8 Acute lymphoblastic leukemia (childhood); CRC cis rs9322193 0.886 rs9322198 chr6:149944908 T/C cg05861140 chr6:150128134 PCMT1 -0.36 -5.92 -0.31 8.26e-9 Lung cancer; CRC cis rs11122272 0.735 rs2244986 chr1:231537452 C/T cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.56 -8.44 -0.42 1.04e-15 Hemoglobin concentration; CRC cis rs2688608 0.530 rs71507081 chr10:75493136 G/A cg23231163 chr10:75533350 FUT11 -0.37 -5.89 -0.31 9.32e-9 Inflammatory bowel disease; CRC cis rs897984 0.762 rs2054213 chr16:30971810 A/G cg00531865 chr16:30841666 NA 0.46 6.61 0.34 1.59e-10 Dementia with Lewy bodies; CRC cis rs854765 0.929 rs854766 chr17:18012775 A/G cg24612305 chr17:17875800 TOM1L2;LRRC48 0.5 7.57 0.39 3.72e-13 Total body bone mineral density; CRC cis rs911119 0.837 rs2208289 chr20:23579526 A/G cg16589663 chr20:23618590 CST3 -0.49 -7.25 -0.37 3.09e-12 Chronic kidney disease; CRC cis rs7091068 0.662 rs829106 chr10:95441742 G/T cg20715218 chr10:95462985 C10orf4 0.56 5.88 0.31 1.03e-8 Urinary tract infection frequency; CRC cis rs6499129 0.558 rs9934328 chr16:67573367 G/C cg26727032 chr16:67993705 SLC12A4 -0.62 -8.04 -0.41 1.68e-14 Waist-to-hip ratio adjusted for body mass index; CRC cis rs7552404 0.696 rs12140121 chr1:76455001 A/G cg03433033 chr1:76189801 ACADM 0.69 8.16 0.41 7.37e-15 Blood metabolite levels;Acylcarnitine levels; CRC cis rs2197308 0.692 rs1904964 chr12:37933241 T/A cg26384229 chr12:38710491 ALG10B 0.67 8.98 0.44 2.06e-17 Morning vs. evening chronotype; CRC cis rs11577318 0.853 rs7416513 chr1:26647949 G/C cg00852783 chr1:26633632 UBXN11 0.47 6.5 0.34 2.94e-10 Granulocyte percentage of myeloid white cells; CRC cis rs2011503 0.882 rs2060276 chr19:19522491 T/G cg11584989 chr19:19387371 SF4 0.54 5.65 0.3 3.5e-8 Bipolar disorder; CRC cis rs8060686 0.516 rs73612297 chr16:68284754 T/G cg26727032 chr16:67993705 SLC12A4 -0.62 -8.86 -0.44 5.03e-17 HDL cholesterol;Metabolic syndrome; CRC cis rs7772486 0.875 rs1331639 chr6:146431869 A/G cg13319975 chr6:146136371 FBXO30 0.4 6.14 0.32 2.41e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs2251381 0.750 rs8129616 chr21:30520085 C/T cg08807101 chr21:30365312 RNF160 -0.64 -9.52 -0.46 3.92e-19 Selective IgA deficiency; CRC cis rs28386778 0.897 rs4968663 chr17:61835603 A/T cg23090583 chr17:61904693 PSMC5;FTSJ3 1.04 20.64 0.75 2.54e-61 Prudent dietary pattern; CRC trans rs4965869 0.703 rs2643356 chr15:101971388 A/G cg17508591 chr5:140214138 PCDHA6;PCDHA2;PCDHA1;PCDHA7;PCDHA5;PCDHA3;PCDHA4 0.28 6.17 0.32 2.04e-9 Platelet-derived growth factor BB levels; CRC cis rs3741404 0.560 rs17699798 chr11:63898806 C/G cg06243084 chr11:63990629 FERMT3 0.45 7.23 0.37 3.32e-12 Platelet count; CRC cis rs3806843 1.000 rs6870764 chr5:140171790 C/T cg19875535 chr5:140030758 IK 0.6 9.84 0.48 3.35e-20 Depressive symptoms (multi-trait analysis); CRC cis rs10256972 0.552 rs2949192 chr7:1203841 C/T cg07092213 chr7:1199455 ZFAND2A -0.47 -6.97 -0.36 1.73e-11 Longevity;Endometriosis; CRC cis rs72945132 0.607 rs67767222 chr11:70121610 T/A cg14191688 chr11:70257035 CTTN 0.42 5.85 0.31 1.18e-8 Coronary artery disease; CRC cis rs1580019 0.539 rs11769109 chr7:32571352 A/G cg14728415 chr7:32535168 LSM5;AVL9 0.43 6.18 0.32 1.89e-9 Cognitive ability; CRC cis rs12497850 0.931 rs7643368 chr3:48992855 T/G cg20833759 chr3:49053208 WDR6;DALRD3 0.54 9.38 0.46 1.08e-18 Parkinson's disease; CRC cis rs2013441 1.000 rs9900166 chr17:20192969 G/A cg13482628 chr17:19912719 NA -0.4 -6.16 -0.32 2.09e-9 Obesity-related traits; CRC cis rs6502050 0.769 rs11658272 chr17:80084596 C/T cg02741985 chr17:80059408 CCDC57 -0.44 -7.15 -0.37 5.61e-12 Life satisfaction; CRC cis rs4523957 0.651 rs7214741 chr17:2085598 C/T cg16513277 chr17:2031491 SMG6 -0.62 -10.52 -0.5 1.73e-22 Autism spectrum disorder or schizophrenia;Schizophrenia; CRC cis rs7586879 0.559 rs13387729 chr2:25076126 A/G cg22495460 chr2:25135724 ADCY3 -0.78 -14.35 -0.62 1.37e-36 Body mass index; CRC cis rs7618501 0.633 rs6792892 chr3:49995518 T/C cg24110177 chr3:50126178 RBM5 -0.45 -6.71 -0.35 8.44e-11 Intelligence (multi-trait analysis); CRC cis rs7937682 0.632 rs2070894 chr11:111780837 G/A cg19812747 chr11:111475976 SIK2 0.43 6.2 0.32 1.65e-9 Primary sclerosing cholangitis; CRC cis rs9372498 0.536 rs28605789 chr6:118889952 G/A cg07617317 chr6:118971624 C6orf204 0.5 6.13 0.32 2.57e-9 Diastolic blood pressure; CRC cis rs4819052 0.788 rs2236449 chr21:46702506 C/T cg19498844 chr21:46707878 POFUT2;LOC642852 0.76 10.82 0.51 1.56e-23 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs9311474 0.508 rs11718420 chr3:52611413 T/C cg15147215 chr3:52552868 STAB1 -0.65 -11.29 -0.53 3.36e-25 Electroencephalogram traits; CRC cis rs9894429 0.966 rs7405901 chr17:79587813 T/C cg13777783 chr17:79615861 NA -0.3 -5.72 -0.3 2.44e-8 Eye color traits; CRC cis rs2153535 0.580 rs1119691 chr6:8460452 C/T cg07606381 chr6:8435919 SLC35B3 0.68 10.95 0.52 5.22e-24 Motion sickness; CRC cis rs875971 1.000 rs6961717 chr7:65587537 C/T cg12463550 chr7:65579703 CRCP -0.47 -6.75 -0.35 6.72e-11 Aortic root size; CRC cis rs11587400 0.532 rs2268700 chr1:115228879 T/G cg12756093 chr1:115239321 AMPD1 -0.56 -7.87 -0.4 5.25e-14 Autism; CRC cis rs73200209 0.744 rs61354255 chr12:116444609 A/T cg01776926 chr12:116560359 MED13L -0.62 -7.24 -0.37 3.15e-12 Total body bone mineral density; CRC cis rs7584330 0.697 rs60278044 chr2:238357118 A/G cg14458575 chr2:238380390 NA 0.66 11.66 0.54 1.59e-26 Prostate cancer; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg03686870 chr4:103682143 MANBA 0.4 6.4 0.33 5.35e-10 Liver disease severity in Alagille syndrome; CRC cis rs9462846 0.691 rs67059212 chr6:42913269 T/G cg05552183 chr6:42928497 GNMT 0.47 6.57 0.34 1.92e-10 Blood protein levels; CRC trans rs7618501 0.521 rs2883059 chr3:49902160 C/T cg21659725 chr3:3221576 CRBN -0.53 -7.74 -0.39 1.21e-13 Intelligence (multi-trait analysis); CRC cis rs758324 0.947 rs6886188 chr5:131178252 C/T cg06307176 chr5:131281290 NA 0.44 6.43 0.33 4.48e-10 Alzheimer's disease in APOE e4- carriers; CRC cis rs2281845 0.507 rs12025414 chr1:201100496 A/G cg08885800 chr1:201084119 NA 0.41 5.7 0.3 2.62e-8 Permanent tooth development; CRC cis rs4665809 1.000 rs10048648 chr2:26320315 T/C cg04944784 chr2:26401820 FAM59B -0.58 -7.67 -0.39 1.97e-13 Gut microbiome composition (summer); CRC cis rs6500602 0.610 rs1659499 chr16:4595269 G/A cg08645402 chr16:4508243 NA -0.6 -10.48 -0.5 2.3e-22 Schizophrenia; CRC cis rs6748734 0.625 rs4295000 chr2:241821237 C/T cg16358738 chr2:241808595 AGXT -0.4 -6.99 -0.36 1.57e-11 Urinary metabolites; CRC cis rs2404602 0.647 rs11072618 chr15:77019342 A/G cg03037974 chr15:76606532 NA -0.53 -7.58 -0.39 3.5e-13 Blood metabolite levels; CRC trans rs2303319 0.504 rs62189055 chr2:162625749 C/A cg22902534 chr3:183892754 AP2M1 -0.72 -6.24 -0.33 1.32e-9 Cognitive function; CRC cis rs7651039 0.619 rs7640807 chr3:15685137 A/G cg16303742 chr3:15540471 COLQ 0.46 7.1 0.36 7.67e-12 Coronary heart disease; CRC cis rs1865760 0.613 rs9358894 chr6:25923315 C/T cg17691542 chr6:26056736 HIST1H1C 0.44 6.65 0.34 1.19e-10 Height; CRC trans rs6693295 0.793 rs2787953 chr1:246248659 T/A cg03680032 chr11:94965610 SESN3 0.48 6.17 0.32 1.98e-9 Migraine - clinic-based;Migraine with aura; CRC cis rs10504229 1.000 rs73607871 chr8:58173007 T/C cg01721255 chr8:58191610 C8orf71 0.49 6.17 0.32 2e-9 Developmental language disorder (linguistic errors); CRC cis rs7119 0.745 rs12911649 chr15:77807127 C/T cg27398640 chr15:77910606 LINGO1 -0.45 -7.78 -0.39 9.51e-14 Type 2 diabetes; CRC trans rs4843747 0.671 rs9921236 chr16:88117015 G/T cg26811252 chr16:29126840 RRN3P2 0.61 8.16 0.41 7.06e-15 Menopause (age at onset); CRC cis rs17376456 0.825 rs55724660 chr5:93276636 A/G cg21475434 chr5:93447410 FAM172A 0.82 7.84 0.4 6.37e-14 Diabetic retinopathy; CRC cis rs853679 0.517 rs9357066 chr6:28129831 T/C cg23161317 chr6:28129485 ZNF389 0.53 6.43 0.33 4.52e-10 Depression; CRC cis rs7534824 0.543 rs61780298 chr1:101402982 T/G cg16556008 chr1:101360663 SLC30A7;EXTL2 0.57 5.86 0.31 1.11e-8 Refractive astigmatism; CRC cis rs1507153 0.651 rs9350781 chr6:79481815 A/T cg09184832 chr6:79620586 NA -0.38 -6.22 -0.32 1.53e-9 Sjögren's syndrome; CRC cis rs7617773 0.817 rs13059037 chr3:48287879 A/G cg11946769 chr3:48343235 NME6 0.72 9.75 0.47 6.92e-20 Coronary artery disease; CRC cis rs10791323 0.602 rs7946895 chr11:133733893 T/C cg06766960 chr11:133703094 NA -0.41 -7.15 -0.37 5.73e-12 Childhood ear infection; CRC cis rs2576037 0.583 rs2156049 chr18:44455717 G/A cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.56 -8.81 -0.44 7.5e-17 Personality dimensions; CRC cis rs736408 0.812 rs2270197 chr3:52824095 T/G cg05573699 chr3:52720067 GNL3;PBRM1 -0.45 -5.88 -0.31 1.01e-8 Bipolar disorder; CRC cis rs6502050 0.777 rs7406162 chr17:80086386 C/T cg13198984 chr17:80129470 CCDC57 -0.48 -8.55 -0.43 4.57e-16 Life satisfaction; CRC cis rs12824058 0.737 rs11060829 chr12:130814996 G/T cg26677194 chr12:130822605 PIWIL1 0.45 7.3 0.37 2.23e-12 Menopause (age at onset); CRC cis rs4713118 0.513 rs200971 chr6:27858904 C/T cg12273811 chr6:28175739 NA 0.55 7.69 0.39 1.7e-13 Parkinson's disease; CRC cis rs6502050 0.799 rs7502524 chr17:80107261 C/T cg25804541 chr17:80189381 SLC16A3 -0.31 -5.97 -0.31 6.08e-9 Life satisfaction; CRC trans rs3942852 0.774 rs2279823 chr11:48146092 T/C cg03929089 chr4:120376271 NA -0.54 -6.77 -0.35 5.98e-11 Acute lymphoblastic leukemia (childhood); CRC cis rs394563 0.781 rs61516098 chr6:149794289 A/T cg11245181 chr6:149772854 ZC3H12D -0.55 -9.19 -0.45 4.73e-18 Dupuytren's disease; CRC cis rs10540 1.000 rs35231079 chr11:515224 G/A cg15790184 chr11:494944 RNH1 0.61 6.24 0.33 1.35e-9 Body mass index; CRC cis rs4713118 0.513 rs1225591 chr6:28148752 G/A cg15845792 chr6:28175446 NA 0.82 12.19 0.56 1.77e-28 Parkinson's disease; CRC cis rs9942416 0.660 rs17563686 chr5:74984818 A/T cg00601450 chr5:74908170 NA 0.41 5.85 0.31 1.21e-8 Age-related disease endophenotypes; CRC cis rs2179367 0.959 rs489551 chr6:149689457 A/G cg07828024 chr6:149772892 ZC3H12D -0.37 -6.04 -0.32 4.22e-9 Dupuytren's disease; CRC cis rs9435341 0.965 rs1730859 chr1:107617707 A/G cg15468180 chr1:107600409 PRMT6 0.42 6.29 0.33 9.84e-10 Facial morphology (factor 21, depth of nasal alae); CRC cis rs9522267 0.535 rs11069899 chr13:112231553 T/C cg14352298 chr13:112236639 NA 0.3 6.7 0.35 9.27e-11 Hepatitis; CRC cis rs1008375 1.000 rs4698635 chr4:17630242 C/A cg04450456 chr4:17643702 FAM184B 0.36 5.75 0.3 1.99e-8 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs4566357 0.615 rs3769642 chr2:227917323 T/C cg11843606 chr2:227700838 RHBDD1 -0.44 -6.81 -0.35 4.52e-11 Coronary artery disease; CRC trans rs7580658 0.614 rs7585198 chr2:127962635 C/T cg20477929 chr11:70116563 PPFIA1 -0.43 -6.09 -0.32 3.2e-9 Protein C levels; CRC cis rs9486719 1.000 rs3798296 chr6:97052286 G/A cg06623918 chr6:96969491 KIAA0776 -0.81 -9.54 -0.47 3.27e-19 Migraine;Coronary artery disease; CRC cis rs941873 0.805 rs876678 chr10:81111036 G/T cg09469691 chr10:81107165 PPIF 0.49 7.76 0.39 1.06e-13 Height; CRC cis rs1559088 0.901 rs7249983 chr19:33598851 C/A cg27124370 chr19:33622961 WDR88 0.44 6.19 0.32 1.78e-9 Bone ultrasound measurement (broadband ultrasound attenuation); CRC trans rs9467711 0.606 rs2076030 chr6:26426856 G/A cg06606381 chr12:133084897 FBRSL1 -0.83 -6.42 -0.33 4.83e-10 Autism spectrum disorder or schizophrenia; CRC cis rs4889855 0.530 rs9901467 chr17:78574008 G/A cg16591659 chr17:78472290 NA -0.41 -6.04 -0.32 4.18e-9 Fractional excretion of uric acid; CRC trans rs7395662 0.963 rs1588068 chr11:48671745 C/G cg21153622 chr11:89784906 NA -0.44 -7.09 -0.36 8.39e-12 HDL cholesterol; CRC cis rs7772486 0.790 rs2253768 chr6:146199922 A/G cg13319975 chr6:146136371 FBXO30 -0.46 -6.83 -0.35 4.03e-11 Lobe attachment (rater-scored or self-reported); CRC cis rs11758351 0.866 rs2069018 chr6:26205718 T/C cg22723502 chr6:26240528 HIST1H4F -0.39 -6.33 -0.33 8.03e-10 Gout;Renal underexcretion gout; CRC cis rs6893807 0.943 rs13166120 chr5:87948883 G/A cg09002922 chr5:87956389 LOC645323 -0.45 -6.58 -0.34 1.91e-10 Body mass index; CRC cis rs72772090 0.539 rs11740375 chr5:96112897 C/G cg17330273 chr5:96107758 CAST;ERAP1 -0.63 -5.74 -0.3 2.12e-8 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg19617932 chr12:1703704 FBXL14 0.38 6.04 0.32 4.06e-9 Liver disease severity in Alagille syndrome; CRC cis rs2223471 0.967 rs760899 chr6:50693607 T/C cg03432817 chr6:50765336 NA 0.39 6.31 0.33 8.97e-10 Subcutaneous adipose tissue; CRC cis rs9486719 1.000 rs2064947 chr6:97052754 C/T cg06623918 chr6:96969491 KIAA0776 -0.71 -8.47 -0.42 8.43e-16 Migraine;Coronary artery disease; CRC cis rs1048238 0.506 rs12023422 chr1:16187625 G/A cg21385522 chr1:16154831 NA 0.64 9.22 0.45 3.65e-18 Systolic blood pressure; CRC trans rs8073060 0.544 rs17550716 chr17:33893208 A/G cg19694781 chr19:47549865 TMEM160 1.0 14.27 0.62 2.71e-36 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; CRC trans rs10492002 0.800 rs7311803 chr12:81546193 A/G cg26598540 chr8:10753147 NA -0.32 -6.01 -0.31 5.05e-9 Response to antidepressant treatment (citalopram); CRC cis rs35110281 0.782 rs9981291 chr21:45031458 A/G cg04455712 chr21:45112962 RRP1B 0.41 8.02 0.4 1.88e-14 Mean corpuscular volume; CRC cis rs4604732 0.578 rs12040725 chr1:247644697 T/A cg12758973 chr1:247694275 LOC148824;OR2C3 0.44 6.35 0.33 7.05e-10 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CRC cis rs9682041 0.673 rs1511175 chr3:170076006 C/G cg11886554 chr3:170076028 SKIL 1.1 10.95 0.52 5.32e-24 Glomerular filtration rate in non diabetics (creatinine);Glomerular filtration rate (creatinine); CRC cis rs3733585 0.638 rs28715627 chr4:9958140 T/A cg11266682 chr4:10021025 SLC2A9 -0.47 -9.63 -0.47 1.69e-19 Cleft plate (environmental tobacco smoke interaction); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg21955402 chr17:18163716 SMCR7 0.43 6.22 0.32 1.54e-9 Response to antipsychotic treatment; CRC cis rs1448094 0.512 rs4488288 chr12:86245450 A/C cg25456477 chr12:86230367 RASSF9 0.32 5.67 0.3 3.13e-8 Major depressive disorder; CRC cis rs9322193 0.923 rs17745062 chr6:150042215 T/A cg00933542 chr6:150070202 PCMT1 0.3 6.26 0.33 1.17e-9 Lung cancer; CRC cis rs9322193 0.923 rs9767105 chr6:149980727 A/G cg05036130 chr6:150231994 NA 0.27 5.65 0.3 3.46e-8 Lung cancer; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg23815043 chr16:88729854 MGC23284;MVD 0.47 6.81 0.35 4.68e-11 Response to antipsychotic treatment; CRC cis rs13096480 0.583 rs17598137 chr3:49891362 G/T cg05127553 chr3:49823860 IP6K1 0.37 5.66 0.3 3.36e-8 Intelligence (multi-trait analysis); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg00320862 chr3:170588302 RPL22L1 0.38 6.03 0.32 4.46e-9 Liver disease severity in Alagille syndrome; CRC cis rs13191362 1.000 rs13209728 chr6:162997533 A/C cg21926612 chr6:163149169 PACRG;PARK2 0.77 11.26 0.53 4.18e-25 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs8060686 0.641 rs12445533 chr16:68082527 A/G cg26727032 chr16:67993705 SLC12A4 -0.56 -6.47 -0.34 3.57e-10 HDL cholesterol;Metabolic syndrome; CRC cis rs2836974 0.966 rs2836977 chr21:40666066 T/C cg11644478 chr21:40555479 PSMG1 0.79 11.82 0.55 4.31e-27 Cognitive function; CRC cis rs4731207 0.596 rs2170353 chr7:124595169 T/G cg23710748 chr7:124431027 NA -0.38 -5.98 -0.31 5.66e-9 Cutaneous malignant melanoma; CRC cis rs4665809 0.627 rs13032756 chr2:26489730 A/T cg04944784 chr2:26401820 FAM59B 0.86 11.49 0.54 6.38e-26 Gut microbiome composition (summer); CRC cis rs6964587 1.000 rs7806157 chr7:91601930 A/G cg17063962 chr7:91808500 NA 0.77 12.66 0.57 3.48e-30 Breast cancer; CRC cis rs10876993 0.928 rs2640636 chr12:58077544 A/G cg15848620 chr12:58087721 OS9 -0.65 -9.21 -0.45 3.84e-18 Celiac disease or Rheumatoid arthritis; CRC cis rs3733585 0.699 rs57574512 chr4:9960182 T/C cg00071950 chr4:10020882 SLC2A9 -0.54 -9.65 -0.47 1.42e-19 Cleft plate (environmental tobacco smoke interaction); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg24085258 chr19:4402334 CHAF1A 0.43 6.14 0.32 2.41e-9 Response to antipsychotic treatment; CRC cis rs4434138 0.594 rs7653028 chr3:52763000 A/T cg11645453 chr3:52864694 ITIH4 0.36 6.51 0.34 2.87e-10 Intelligence (multi-trait analysis); CRC cis rs853679 0.517 rs9393890 chr6:28063855 C/T cg12273811 chr6:28175739 NA 0.73 9.31 0.46 1.82e-18 Depression; CRC cis rs4481887 1.000 rs6697735 chr1:248465315 G/C cg13385794 chr1:248469461 NA 0.37 6.56 0.34 2.1e-10 Common traits (Other); CRC cis rs1005277 0.579 rs2103938 chr10:38493998 T/G cg25427524 chr10:38739819 LOC399744 -0.79 -14.5 -0.62 3.64e-37 Extrinsic epigenetic age acceleration; CRC cis rs12188164 0.686 rs72711365 chr5:416672 G/A cg26850624 chr5:429559 AHRR -0.74 -12.25 -0.56 1.1e-28 Cystic fibrosis severity; CRC trans rs10982213 0.830 rs2274163 chr9:117188714 C/T cg10554839 chr10:27529782 ACBD5 0.39 6.33 0.33 8.23e-10 Interleukin-6 levels; CRC cis rs4144027 0.904 rs10438244 chr14:104346185 A/G cg08213375 chr14:104286397 PPP1R13B -0.36 -5.89 -0.31 9.57e-9 Blood metabolite levels; CRC cis rs8077889 1.000 rs2066725 chr17:41891473 A/G cg26893861 chr17:41843967 DUSP3 0.9 13.45 0.6 3.68e-33 Triglycerides; CRC cis rs3796619 1.000 rs28620427 chr4:1086247 T/G cg11579758 chr4:1086637 RNF212 0.41 6.77 0.35 5.96e-11 Recombination rate (males); CRC cis rs6540559 0.673 rs6694552 chr1:209976459 A/C cg22029157 chr1:209979665 IRF6 0.73 9.51 0.46 4.3e-19 Cleft lip with or without cleft palate; CRC cis rs11690935 0.632 rs6723259 chr2:172622527 A/C cg13550731 chr2:172543902 DYNC1I2 0.67 9.99 0.48 1.08e-20 Schizophrenia; CRC cis rs12464483 0.591 rs2602775 chr2:30883012 C/T cg12454169 chr2:30669597 LCLAT1 0.47 6.11 0.32 2.78e-9 Pre-treatment pain in head and neck squamous cell carcinoma; CRC cis rs7615952 0.599 rs6438955 chr3:125730333 C/A cg02772935 chr3:125709198 NA -0.48 -6.07 -0.32 3.54e-9 Blood pressure (smoking interaction); CRC cis rs6952808 0.760 rs34961072 chr7:1948620 G/C cg00106254 chr7:1943704 MAD1L1 -0.53 -7.55 -0.38 4.43e-13 Bipolar disorder and schizophrenia; CRC cis rs765787 0.530 rs2899378 chr15:45537584 C/T cg24006582 chr15:45444508 DUOX1 0.57 8.25 0.41 3.85e-15 Uric acid levels; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg21962918 chr5:134094454 DDX46 0.39 6.38 0.33 5.87e-10 Liver disease severity in Alagille syndrome; CRC cis rs11997175 0.646 rs4609158 chr8:33693420 A/G cg04338863 chr8:33670619 NA 0.42 6.76 0.35 6.19e-11 Body mass index; CRC cis rs7917772 0.503 rs10748825 chr10:104293609 A/G cg04362960 chr10:104952993 NT5C2 -0.41 -5.79 -0.3 1.62e-8 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC cis rs1799949 1.000 rs12951869 chr17:41187567 T/G cg05368731 chr17:41323189 NBR1 0.69 10.07 0.49 5.76e-21 Menopause (age at onset); CRC cis rs10504229 0.683 rs11786043 chr8:58133174 T/C cg02725872 chr8:58115012 NA -0.64 -11.55 -0.54 3.85e-26 Developmental language disorder (linguistic errors); CRC cis rs394563 0.967 rs444784 chr6:149798366 C/G cg03678062 chr6:149772716 ZC3H12D -0.35 -6.18 -0.32 1.86e-9 Dupuytren's disease; CRC cis rs4268898 1.000 rs1203 chr2:24443330 A/G cg06627628 chr2:24431161 ITSN2 0.51 7.7 0.39 1.59e-13 Asthma; CRC cis rs7937682 0.889 rs11213971 chr11:111529829 A/G cg19812747 chr11:111475976 SIK2 -0.57 -9.67 -0.47 1.21e-19 Primary sclerosing cholangitis; CRC cis rs9527 0.637 rs11191424 chr10:104625886 G/A cg15744005 chr10:104629667 AS3MT -0.39 -8.07 -0.41 1.31e-14 Arsenic metabolism; CRC cis rs8077889 0.871 rs7212648 chr17:41917962 A/C cg16892393 chr17:41919603 NA 0.55 8.0 0.4 2.17e-14 Triglycerides; CRC cis rs8031584 0.541 rs2955797 chr15:31210981 A/G cg08109568 chr15:31115862 NA 0.4 6.49 0.34 3.19e-10 Huntington's disease progression; CRC cis rs2204008 0.837 rs11495722 chr12:38337245 G/A cg13010199 chr12:38710504 ALG10B 0.45 5.73 0.3 2.29e-8 Bladder cancer; CRC cis rs477895 0.653 rs2875749 chr11:63903878 C/A cg19465662 chr11:63993652 NUDT22;TRPT1 0.73 8.97 0.44 2.22e-17 Mean platelet volume; CRC cis rs12612619 0.732 rs7560144 chr2:27280460 A/G cg00617064 chr2:27272375 NA -0.37 -6.14 -0.32 2.36e-9 Venous thromboembolism adjusted for sickle cell variant rs77121243-T; CRC cis rs10504229 0.679 rs72649115 chr8:58037631 T/G cg11062466 chr8:58055876 NA 0.52 6.31 0.33 8.8e-10 Developmental language disorder (linguistic errors); CRC cis rs2811415 0.597 rs11709484 chr3:127745068 C/T cg13719885 chr3:127795394 NA -0.4 -6.02 -0.32 4.62e-9 Lung function (FEV1/FVC); CRC cis rs7666738 0.715 rs61114099 chr4:98931270 C/T cg17366294 chr4:99064904 C4orf37 0.43 7.32 0.37 1.95e-12 Colonoscopy-negative controls vs population controls; CRC cis rs12142240 0.660 rs7520497 chr1:46824919 C/A cg00530320 chr1:46809349 NSUN4 0.59 8.03 0.41 1.69e-14 Menopause (age at onset); CRC trans rs9929218 1.000 rs12599517 chr16:68814590 T/C cg04657470 chr2:198365150 HSPE1;HSPD1 -0.82 -11.54 -0.54 4.33e-26 Colorectal cancer; CRC trans rs2228479 0.850 rs17227057 chr16:89816333 C/T cg21302420 chr1:112162376 RAP1A 0.72 6.01 0.31 5.05e-9 Skin colour saturation; CRC cis rs12142240 0.698 rs17361805 chr1:46813967 C/T cg00530320 chr1:46809349 NSUN4 0.58 7.75 0.39 1.18e-13 Menopause (age at onset); CRC cis rs6570726 0.935 rs416987 chr6:145847005 G/C cg23711669 chr6:146136114 FBXO30 0.68 12.3 0.56 7.07e-29 Lobe attachment (rater-scored or self-reported); CRC cis rs6502050 0.835 rs7406529 chr17:80080877 C/T cg25804541 chr17:80189381 SLC16A3 0.31 6.01 0.31 4.97e-9 Life satisfaction; CRC cis rs4604732 0.536 rs7528219 chr1:247628307 C/T cg02104434 chr1:247694406 LOC148824;OR2C3 0.54 8.15 0.41 7.85e-15 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CRC cis rs6951245 1.000 rs78861357 chr7:1095418 C/T cg07217954 chr7:1067459 C7orf50 0.55 5.72 0.3 2.36e-8 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs243505 0.528 rs6977453 chr7:148474746 A/G cg09806900 chr7:148480153 CUL1 0.57 8.18 0.41 6.11e-15 Inflammatory bowel disease;Crohn's disease; CRC cis rs2115630 0.967 rs12595786 chr15:85336670 T/C cg11189052 chr15:85197271 WDR73 -0.6 -9.92 -0.48 1.77e-20 P wave terminal force; CRC cis rs798554 0.759 rs2644309 chr7:2889034 T/C cg19346786 chr7:2764209 NA -0.41 -6.83 -0.35 4.21e-11 Height; CRC cis rs7216064 0.773 rs74541577 chr17:65853651 C/T cg12091567 chr17:66097778 LOC651250 -0.68 -7.87 -0.4 5.31e-14 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CRC cis rs7827545 1.000 rs7008121 chr8:135565904 T/C cg13086574 chr8:135490821 ZFAT -0.36 -6.08 -0.32 3.29e-9 Hypertension (SNP x SNP interaction); CRC cis rs968567 0.638 rs7943728 chr11:61547068 G/A cg14911132 chr11:61596755 FADS2 -0.55 -6.21 -0.32 1.58e-9 Blood metabolite levels;Rheumatoid arthritis;Vitiligo;Glycerophospholipid levels; CRC cis rs13418455 0.691 rs62182920 chr2:181113573 G/C cg23363182 chr2:181467187 NA 0.4 5.65 0.3 3.48e-8 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs6504950 0.566 rs12937360 chr17:53046298 C/T cg19360675 chr17:53046073 COX11;STXBP4 0.46 6.83 0.35 4e-11 Breast cancer; CRC trans rs2303319 0.504 rs961421 chr2:162626099 G/C cg11326919 chr17:43324904 LOC100133991 -0.64 -5.99 -0.31 5.65e-9 Cognitive function; CRC cis rs8060686 0.641 rs111632263 chr16:68233122 T/A cg26727032 chr16:67993705 SLC12A4 -0.53 -6.23 -0.32 1.46e-9 HDL cholesterol;Metabolic syndrome; CRC cis rs13088645 0.532 rs7623580 chr3:134164345 C/G cg06109529 chr3:134205091 CEP63;ANAPC13 0.51 7.23 0.37 3.37e-12 Coronary artery disease; CRC trans rs1814175 0.645 rs28441045 chr11:50048971 C/T cg15704280 chr7:45808275 SEPT13 -0.94 -17.39 -0.69 1.77e-48 Height; CRC cis rs6952808 0.823 rs58222895 chr7:1885064 G/A cg22963979 chr7:1858916 MAD1L1 -0.58 -9.2 -0.45 4.31e-18 Bipolar disorder and schizophrenia; CRC cis rs4731207 0.698 rs7801140 chr7:124505761 T/C cg23710748 chr7:124431027 NA -0.38 -6.08 -0.32 3.42e-9 Cutaneous malignant melanoma; CRC cis rs9303280 0.870 rs6503524 chr17:38069809 C/T cg20243544 chr17:37824526 PNMT -0.43 -6.67 -0.35 1.09e-10 Self-reported allergy; CRC cis rs28386778 0.897 rs2584617 chr17:61925298 C/T cg23090583 chr17:61904693 PSMC5;FTSJ3 1.04 20.33 0.75 4.47e-60 Prudent dietary pattern; CRC trans rs3851050 0.651 rs10887487 chr10:81852700 A/G cg04055819 chr10:13749602 FRMD4A 0.43 6.01 0.31 4.91e-9 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs812925 0.537 rs2593620 chr2:61613261 A/G cg10580144 chr2:61372316 C2orf74 -0.32 -7.03 -0.36 1.17e-11 Immature fraction of reticulocytes; CRC cis rs394563 0.601 rs376269 chr6:149795154 C/T cg07828024 chr6:149772892 ZC3H12D -0.39 -6.48 -0.34 3.41e-10 Dupuytren's disease; CRC cis rs1799949 0.965 rs35954893 chr17:41333786 A/G cg25072359 chr17:41440525 NA 0.46 6.94 0.36 2.07e-11 Menopause (age at onset); CRC cis rs2188554 0.667 rs213949 chr7:117197031 T/A cg09181792 chr7:117119393 CFTR 0.34 6.16 0.32 2.14e-9 Esophageal adenocarcinoma; CRC cis rs524281 0.647 rs2302883 chr11:65824994 T/C cg14036092 chr11:66035641 RAB1B -0.43 -5.66 -0.3 3.3e-8 Electroencephalogram traits; CRC cis rs7927592 0.546 rs638076 chr11:68202580 A/G cg01657329 chr11:68192670 LRP5 -0.59 -9.5 -0.46 4.42e-19 Total body bone mineral density; CRC cis rs68170813 0.559 rs74584447 chr7:106944755 T/C cg02696742 chr7:106810147 HBP1 -0.59 -6.6 -0.34 1.66e-10 Coronary artery disease; CRC cis rs7493 0.755 rs740264 chr7:95021803 T/G cg17330251 chr7:94953956 PON1 -0.52 -6.56 -0.34 2.04e-10 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs2243480 1.000 rs431318 chr7:65511597 G/A cg12463550 chr7:65579703 CRCP 0.75 6.82 0.35 4.5e-11 Diabetic kidney disease; CRC cis rs2408955 0.500 rs12816820 chr12:48558325 A/G cg21466736 chr12:48725269 NA -0.47 -7.27 -0.37 2.62e-12 Glycated hemoglobin levels; CRC cis rs72781680 0.950 rs72798404 chr2:24180125 C/T cg08917208 chr2:24149416 ATAD2B 1.04 10.13 0.49 3.61e-21 Lymphocyte counts; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg27068619 chr7:149439536 NA 0.43 6.48 0.34 3.3e-10 Intelligence (multi-trait analysis); CRC cis rs6963495 0.769 rs117986187 chr7:105167311 G/A cg13798780 chr7:105162888 PUS7 0.69 8.2 0.41 5.36e-15 Bipolar disorder (body mass index interaction); CRC cis rs6545883 0.860 rs13023037 chr2:61620989 C/T cg15711740 chr2:61764176 XPO1 0.45 5.95 0.31 6.95e-9 Tuberculosis; CRC cis rs4363385 0.747 rs946100 chr1:152971663 C/T cg25856811 chr1:152973957 SPRR3 0.26 7.14 0.37 6.1e-12 Inflammatory skin disease; CRC cis rs9894429 0.646 rs58398000 chr17:79576923 G/A cg21028142 chr17:79581711 NPLOC4 -0.34 -7.1 -0.36 7.5e-12 Eye color traits; CRC cis rs875971 0.862 rs6958294 chr7:65794796 C/A cg18876405 chr7:65276391 NA -0.54 -8.68 -0.43 1.88e-16 Aortic root size; CRC cis rs12410462 0.681 rs6681096 chr1:227609720 G/A cg04117972 chr1:227635322 NA 0.77 8.03 0.4 1.73e-14 Major depressive disorder; CRC cis rs1153858 1.000 rs12439274 chr15:45636667 A/G cg14582100 chr15:45693742 SPATA5L1 0.3 6.33 0.33 7.86e-10 Homoarginine levels; CRC cis rs7945705 0.714 rs2653570 chr11:8987823 A/G cg21881798 chr11:8931708 C11orf17;ST5 -0.66 -11.06 -0.52 2.19e-24 Hemoglobin concentration; CRC cis rs8014204 0.566 rs12587457 chr14:75164141 C/T cg03030879 chr14:75389066 RPS6KL1 -0.38 -6.19 -0.32 1.74e-9 Caffeine consumption; CRC cis rs2742417 1.000 rs2742389 chr3:45756683 G/C cg04837898 chr3:45731254 SACM1L -0.35 -5.73 -0.3 2.26e-8 Response to anti-depressant treatment in major depressive disorder; CRC trans rs5756813 0.661 rs7286550 chr22:38196760 G/A cg19894588 chr14:64061835 NA -0.62 -8.41 -0.42 1.3e-15 Optic cup area;Vertical cup-disc ratio; CRC trans rs1005277 0.579 rs1740732 chr10:38491385 C/T cg17830980 chr10:43048298 ZNF37B -0.57 -9.58 -0.47 2.55e-19 Extrinsic epigenetic age acceleration; CRC cis rs875971 0.862 rs709609 chr7:65560561 A/G cg18252515 chr7:66147081 NA 0.4 5.9 0.31 9.26e-9 Aortic root size; CRC cis rs10924970 0.663 rs12749180 chr1:235364105 G/C cg09010748 chr1:235293032 TOMM20 -0.4 -5.64 -0.3 3.72e-8 Asthma; CRC cis rs11574514 1.000 rs28367503 chr16:67854534 A/G cg26727032 chr16:67993705 SLC12A4 -0.62 -6.02 -0.31 4.73e-9 Crohn's disease; CRC cis rs1799949 0.930 rs8176194 chr17:41231221 A/C cg19454999 chr17:41278357 BRCA1;NBR2 0.55 8.53 0.43 5.48e-16 Menopause (age at onset); CRC cis rs853679 0.517 rs1904841 chr6:28108085 C/T cg12172441 chr6:28176163 NA 0.62 7.31 0.37 2.06e-12 Depression; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg06188024 chr6:88182584 SLC35A1 0.44 6.34 0.33 7.67e-10 Intelligence (multi-trait analysis); CRC cis rs9381040 0.610 rs2268195 chr6:41024340 G/A cg03644281 chr6:41068752 NFYA;LOC221442 -0.44 -6.33 -0.33 8.04e-10 Alzheimer's disease (late onset); CRC cis rs6964587 0.967 rs28615927 chr7:91600648 C/A cg17063962 chr7:91808500 NA 0.8 14.25 0.62 3.19e-36 Breast cancer; CRC cis rs10191773 0.589 rs72831639 chr2:112949291 A/G cg04979063 chr2:113191202 RGPD5;RGPD8 0.68 5.95 0.31 6.68e-9 Yeast infection; CRC cis rs9811920 0.609 rs7636447 chr3:99612677 G/C cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G 0.47 6.24 0.33 1.38e-9 Axial length; CRC cis rs11785400 0.793 rs13248524 chr8:143739343 T/C cg24634471 chr8:143751801 JRK 0.47 6.38 0.33 5.98e-10 Schizophrenia; CRC cis rs597539 0.652 rs613128 chr11:68638058 G/T cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.89 15.85 0.66 1.89e-42 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs7945718 0.967 rs11022496 chr11:12789561 G/A cg25843174 chr11:12811716 TEAD1 0.5 9.65 0.47 1.5e-19 Educational attainment (years of education); CRC cis rs8008758 1.000 rs8013718 chr14:101689506 C/T cg26224664 chr14:101693935 NA -0.39 -5.88 -0.31 1.03e-8 Body mass index (alcohol intake interaction); CRC cis rs10504229 0.593 rs75047131 chr8:58001320 A/G cg20607798 chr8:58055168 NA 0.49 5.67 0.3 3.21e-8 Developmental language disorder (linguistic errors); CRC cis rs4862750 0.794 rs1030382 chr4:187903782 T/G cg06074448 chr4:187884817 NA -0.57 -10.12 -0.49 3.76e-21 Lobe attachment (rater-scored or self-reported); CRC cis rs4722166 0.532 rs4719713 chr7:22758811 G/A cg05472934 chr7:22766657 IL6 0.66 10.37 0.5 5.58e-22 Lung cancer; CRC cis rs7224685 0.501 rs4790171 chr17:4022899 T/C cg11204139 chr17:3907470 NA -0.76 -13.78 -0.61 1.97e-34 Type 2 diabetes; CRC trans rs11039798 0.764 rs10838882 chr11:48393035 T/A cg03929089 chr4:120376271 NA 0.63 6.15 0.32 2.29e-9 Axial length; CRC cis rs11785400 0.762 rs7017931 chr8:143726728 A/G cg24634471 chr8:143751801 JRK 0.51 7.08 0.36 8.81e-12 Schizophrenia; CRC cis rs887829 0.570 rs45615240 chr2:234599296 T/C cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.45 -7.06 -0.36 9.85e-12 Metabolic traits;Bilirubin levels;Cholelithiasis-related traits in sickle cell anemia;Metabolite levels;Total bilirubin levels in HIV-1 infection;Serum metabolite levels;Blood metabolite levels; CRC cis rs7918232 0.941 rs1085782 chr10:27440517 G/A cg14442939 chr10:27389572 ANKRD26 -0.82 -9.06 -0.45 1.15e-17 Breast cancer; CRC cis rs1862618 0.853 rs252922 chr5:56136343 G/T cg20203395 chr5:56204925 C5orf35 -0.69 -8.2 -0.41 5.44e-15 Initial pursuit acceleration; CRC cis rs12497850 0.931 rs9876848 chr3:48844059 G/A cg20833759 chr3:49053208 WDR6;DALRD3 0.53 9.07 0.45 1.13e-17 Parkinson's disease; CRC cis rs13088645 0.683 rs9790169 chr3:134151959 C/T cg06109529 chr3:134205091 CEP63;ANAPC13 -0.49 -7.39 -0.38 1.24e-12 Coronary artery disease; CRC cis rs2072510 0.569 rs17677343 chr12:96397081 T/A cg09636302 chr12:96389483 HAL -0.52 -6.38 -0.33 5.86e-10 Metabolite levels (small molecules and protein measures); CRC cis rs10788264 0.504 rs10749452 chr10:124028141 A/G cg09507567 chr10:124027408 NA 0.36 7.65 0.39 2.24e-13 Total body bone mineral density; CRC cis rs8078723 0.630 rs60137005 chr17:38129996 A/T cg17344932 chr17:38183730 MED24;SNORD124 -0.53 -8.73 -0.43 1.31e-16 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); CRC cis rs6500602 0.647 rs1641868 chr16:4594503 G/C cg08645402 chr16:4508243 NA 0.6 10.5 0.5 1.98e-22 Schizophrenia; CRC cis rs972578 1.000 rs733139 chr22:43390083 A/T cg01576275 chr22:43409880 NA -0.49 -7.91 -0.4 3.96e-14 Mean platelet volume; CRC cis rs6502050 0.835 rs7209474 chr17:80136418 C/T cg22110888 chr17:80059540 CCDC57 0.42 6.54 0.34 2.4e-10 Life satisfaction; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg17437088 chr7:130698670 FLJ43663 0.41 6.94 0.36 2.1e-11 Liver disease severity in Alagille syndrome; CRC cis rs9649213 0.593 rs1468338 chr7:97951118 T/C cg00277769 chr7:97922759 BAIAP2L1 -0.61 -10.7 -0.51 4.06e-23 Prostate cancer (SNP x SNP interaction); CRC trans rs2303319 0.582 rs56094729 chr2:162464835 C/T cg18122310 chr12:50236657 BCDIN3D -0.73 -6.13 -0.32 2.58e-9 Cognitive function; CRC trans rs7618501 0.602 rs10049087 chr3:50123417 A/G cg21659725 chr3:3221576 CRBN -0.62 -9.76 -0.47 6.07e-20 Intelligence (multi-trait analysis); CRC cis rs362272 0.505 rs60208975 chr4:3364530 A/G cg08741688 chr4:3415352 RGS12 -0.41 -6.04 -0.32 4.12e-9 Serum sulfate level; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg14239635 chr6:116892067 RWDD1 0.52 6.88 0.35 3.12e-11 Thyroid stimulating hormone; CRC trans rs7267979 0.868 rs6107019 chr20:25233985 C/T cg17903999 chr18:56338584 MALT1 -0.41 -6.48 -0.34 3.33e-10 Liver enzyme levels (alkaline phosphatase); CRC cis rs8040855 0.597 rs12902942 chr15:85584804 C/T cg10818794 chr15:86012489 AKAP13 -0.44 -5.87 -0.31 1.07e-8 Bulimia nervosa; CRC cis rs3785574 0.638 rs2854182 chr17:61969062 G/A cg06873352 chr17:61820015 STRADA 0.47 7.28 0.37 2.46e-12 Height; CRC trans rs2795502 0.882 rs2744093 chr10:43339243 A/G cg06791473 chr12:49259579 RND1 0.61 6.03 0.32 4.5e-9 Blood protein levels; CRC cis rs17711722 1.000 rs17711722 chr7:65271197 C/T cg11764359 chr7:65958608 NA -0.52 -7.92 -0.4 3.67e-14 Calcium levels; CRC cis rs2276314 0.857 rs28651028 chr18:33638910 G/A cg05985134 chr18:33552581 C18orf21 0.48 6.74 0.35 7.06e-11 Endometriosis;Drug-induced torsades de pointes; CRC cis rs12230513 0.732 rs6581047 chr12:55832001 C/G cg19537932 chr12:55886519 OR6C68 -0.73 -9.49 -0.46 5.01e-19 Contrast sensitivity; CRC cis rs2281845 0.965 rs3738262 chr1:201083343 A/G cg17810781 chr1:201082982 CACNA1S 0.48 8.07 0.41 1.3e-14 Permanent tooth development; CRC cis rs9768139 0.935 rs7800718 chr7:158121878 G/A cg24154853 chr7:158122151 PTPRN2 -0.6 -9.93 -0.48 1.72e-20 Calcium levels; CRC cis rs7527798 0.592 rs6667118 chr1:207822724 G/T cg09232269 chr1:207846808 CR1L -0.47 -7.66 -0.39 2.16e-13 Erythrocyte sedimentation rate; CRC cis rs1799949 1.000 rs34572725 chr17:41428666 G/A cg05368731 chr17:41323189 NBR1 0.66 9.98 0.48 1.19e-20 Menopause (age at onset); CRC cis rs2731664 0.792 rs466256 chr5:176875956 C/A cg23176889 chr5:176863531 GRK6 -0.75 -16.13 -0.66 1.62e-43 Intelligence (multi-trait analysis); CRC cis rs9902453 0.904 rs7225686 chr17:28356744 C/A cg26525008 chr17:28256777 EFCAB5;SSH2 -0.69 -11.35 -0.53 2.01e-25 Coffee consumption (cups per day); CRC cis rs3733346 0.505 rs11734449 chr4:921733 C/A cg20814179 chr4:940893 TMEM175 0.58 9.7 0.47 9.92e-20 Sjögren's syndrome; CRC cis rs736408 0.522 rs998909 chr3:52805093 A/G cg08222913 chr3:52553049 STAB1 -0.34 -6.29 -0.33 1.02e-9 Bipolar disorder; CRC cis rs394563 0.591 rs237028 chr6:149718650 C/T cg16235748 chr6:149772707 ZC3H12D -0.37 -6.78 -0.35 5.58e-11 Dupuytren's disease; CRC cis rs3091242 0.933 rs11802413 chr1:25760920 A/G cg02931644 chr1:25747376 RHCE -0.33 -5.75 -0.3 2.07e-8 Erythrocyte sedimentation rate; CRC cis rs13161895 0.702 rs74507840 chr5:179487430 G/A cg02702477 chr5:179499311 RNF130 0.83 8.65 0.43 2.24e-16 LDL cholesterol; CRC cis rs7119 0.667 rs907390 chr15:77902419 T/C cg27398640 chr15:77910606 LINGO1 0.45 8.62 0.43 2.86e-16 Type 2 diabetes; CRC cis rs9287719 0.649 rs6732429 chr2:10758972 C/T cg00105475 chr2:10696890 NA -0.42 -6.55 -0.34 2.22e-10 Prostate cancer; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg22817198 chr14:93651628 C14orf109;MOAP1 0.39 6.05 0.32 4e-9 Intelligence (multi-trait analysis); CRC cis rs172166 0.637 rs1233708 chr6:28173219 C/T cg12172441 chr6:28176163 NA 0.55 7.75 0.39 1.12e-13 Cardiac Troponin-T levels; CRC cis rs3741404 0.584 rs645461 chr11:63893694 C/T cg06219103 chr11:63990595 FERMT3 0.45 7.01 0.36 1.33e-11 Platelet count; CRC cis rs58688157 0.705 rs936469 chr11:606749 G/A cg03909863 chr11:638404 DRD4 -0.51 -6.85 -0.35 3.61e-11 Systemic lupus erythematosus; CRC cis rs9611565 0.802 rs9611571 chr22:41784867 G/A cg06634786 chr22:41940651 POLR3H -0.6 -7.1 -0.36 7.74e-12 Vitiligo; CRC cis rs72781680 0.611 rs2303289 chr2:24342242 C/G cg06627628 chr2:24431161 ITSN2 0.53 6.16 0.32 2.07e-9 Lymphocyte counts; CRC cis rs11098499 0.863 rs3775854 chr4:120471971 C/T cg24375607 chr4:120327624 NA 0.48 7.3 0.37 2.12e-12 Corneal astigmatism; CRC cis rs2180341 0.920 rs4472373 chr6:127705983 G/A cg27446573 chr6:127587934 RNF146 0.98 13.78 0.6 2.04e-34 Breast cancer; CRC cis rs600231 0.719 rs7114809 chr11:65251444 A/G cg17120908 chr11:65337727 SSSCA1 -0.59 -9.05 -0.45 1.31e-17 Bone mineral density; CRC cis rs12286929 0.898 rs11215384 chr11:115023851 C/G cg04055981 chr11:115044050 NA 0.35 5.71 0.3 2.54e-8 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs6860806 0.507 rs273901 chr5:131694360 G/T cg22638593 chr5:131593259 PDLIM4 0.39 6.39 0.33 5.55e-10 Breast cancer; CRC cis rs12148488 0.816 rs11854975 chr15:75363876 C/T cg14664628 chr15:75095509 CSK -0.41 -6.0 -0.31 5.34e-9 Caffeine consumption; CRC cis rs6963495 0.818 rs1355614 chr7:105179176 A/G cg02135003 chr7:105160482 PUS7 -0.66 -9.96 -0.48 1.32e-20 Bipolar disorder (body mass index interaction); CRC cis rs10479542 0.784 rs7703730 chr5:178986632 C/A cg26516362 chr5:178986906 RUFY1 -0.31 -5.61 -0.3 4.29e-8 Lung cancer; CRC cis rs10791323 0.633 rs2171006 chr11:133728323 T/C cg06766960 chr11:133703094 NA -0.42 -7.48 -0.38 6.97e-13 Childhood ear infection; CRC cis rs796364 0.715 rs1106399 chr2:201003837 A/C cg23649088 chr2:200775458 C2orf69 -0.57 -5.89 -0.31 9.63e-9 Schizophrenia; CRC cis rs9549367 0.789 rs3861720 chr13:113906097 A/G cg00898013 chr13:113819073 PROZ -0.46 -6.47 -0.34 3.56e-10 Platelet distribution width; CRC cis rs7917772 0.636 rs4919676 chr10:104524352 C/T cg11453585 chr10:104263688 ACTR1A;SUFU -0.69 -10.28 -0.49 1.15e-21 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC cis rs898097 0.801 rs68141193 chr17:80878816 C/T cg19046167 chr17:80928561 B3GNTL1 -0.42 -6.33 -0.33 8.03e-10 Breast cancer; CRC cis rs7119 0.604 rs2271397 chr15:77907775 T/C cg10437265 chr15:77819839 NA -0.44 -7.84 -0.4 6.35e-14 Type 2 diabetes; CRC cis rs2882667 0.858 rs7724108 chr5:138410922 A/G cg09476006 chr5:138032270 NA -0.43 -6.6 -0.34 1.62e-10 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs7937682 0.575 rs34558891 chr11:111737912 C/T cg09085632 chr11:111637200 PPP2R1B 0.95 15.63 0.65 1.46e-41 Primary sclerosing cholangitis; CRC cis rs4713118 0.824 rs9366702 chr6:27734470 T/C cg02683197 chr6:28174875 NA 0.65 8.41 0.42 1.22e-15 Parkinson's disease; CRC cis rs539096 0.540 rs3011217 chr1:44303266 C/T cg12908607 chr1:44402522 ARTN 0.51 9.18 0.45 5.09e-18 Intelligence (multi-trait analysis); CRC cis rs7493 0.853 rs17166879 chr7:95053415 A/G cg07404485 chr7:94953653 PON1 -0.47 -6.05 -0.32 3.87e-9 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs3617 0.625 rs7612624 chr3:52893426 T/C cg11645453 chr3:52864694 ITIH4 -0.46 -9.18 -0.45 5.03e-18 Red blood cell count;Autism spectrum disorder or schizophrenia; CRC cis rs881375 0.654 rs10760126 chr9:123662618 T/C cg09586646 chr9:123605570 PSMD5;LOC253039 0.47 7.08 0.36 8.85e-12 Rheumatoid arthritis; CRC trans rs1814175 0.715 rs11040586 chr11:49858432 T/A cg03929089 chr4:120376271 NA -0.92 -17.29 -0.69 4.09e-48 Height; CRC cis rs2880765 0.835 rs11638498 chr15:86023018 T/C cg17133734 chr15:86042851 AKAP13 0.42 6.79 0.35 5.35e-11 Coronary artery disease; CRC cis rs1865760 1.000 rs56118523 chr6:25908975 A/G cg17691542 chr6:26056736 HIST1H1C 0.55 8.35 0.42 1.88e-15 Height; CRC cis rs873946 0.648 rs3793673 chr10:134547732 A/C cg27286337 chr10:134555280 INPP5A 0.72 8.89 0.44 4.13e-17 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CRC cis rs6121246 0.909 rs6060979 chr20:30417522 C/T cg13852791 chr20:30311386 BCL2L1 0.61 9.91 0.48 1.99e-20 Mean corpuscular hemoglobin; CRC cis rs1375194 0.606 rs13393407 chr2:33818198 C/T cg04131969 chr2:33951647 MYADML -0.53 -7.8 -0.39 8.4e-14 Response to antidepressants in depression; CRC cis rs7945718 0.621 rs6485978 chr11:12678415 T/C cg25843174 chr11:12811716 TEAD1 0.39 7.17 0.37 4.89e-12 Educational attainment (years of education); CRC cis rs2302190 0.882 rs7216856 chr17:56472295 C/T cg12560992 chr17:57184187 TRIM37 0.48 6.11 0.32 2.78e-9 Vitamin D levels; CRC cis rs853679 0.517 rs4713137 chr6:28083521 C/G cg18032046 chr6:28092343 ZSCAN16 -0.52 -6.02 -0.31 4.76e-9 Depression; CRC trans rs616147 0.850 rs631312 chr3:39508968 A/G cg24004139 chr1:26670703 AIM1L 0.38 6.1 0.32 2.99e-9 Amyotrophic lateral sclerosis;Amyotrophic lateral sclerosis (sporadic); CRC cis rs2882667 0.931 rs3749665 chr5:138357211 A/G cg09476006 chr5:138032270 NA 0.46 7.48 0.38 6.81e-13 Age-related hearing impairment (SNP x SNP interaction); CRC trans rs11148252 0.740 rs7983971 chr13:52790700 C/T cg18335740 chr13:41363409 SLC25A15 0.52 7.65 0.39 2.23e-13 Lewy body disease; CRC cis rs4319547 0.737 rs4758646 chr12:122946507 G/A cg05707623 chr12:122985044 ZCCHC8 -0.54 -7.17 -0.37 4.87e-12 Body mass index; CRC cis rs4604732 0.588 rs7549955 chr1:247628321 G/A cg02104434 chr1:247694406 LOC148824;OR2C3 0.54 8.15 0.41 7.85e-15 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CRC trans rs1005277 0.579 rs2505196 chr10:38393563 G/A cg27523141 chr10:43048294 ZNF37B 0.49 7.21 0.37 3.88e-12 Extrinsic epigenetic age acceleration; CRC cis rs4836694 0.574 rs67899211 chr9:132935614 G/A cg13414629 chr9:132935646 FREQ 0.43 6.25 0.33 1.3e-9 Alzheimer's disease (cognitive decline); CRC trans rs11098499 0.863 rs10030660 chr4:120436704 G/A cg25214090 chr10:38739885 LOC399744 0.64 10.02 0.48 8.38e-21 Corneal astigmatism; CRC cis rs9527 0.545 rs7915816 chr10:104881750 A/G cg15744005 chr10:104629667 AS3MT -0.31 -6.1 -0.32 3.05e-9 Arsenic metabolism; CRC cis rs13256369 0.851 rs13271698 chr8:8567539 C/A cg00074818 chr8:8560427 CLDN23 0.42 7.44 0.38 8.59e-13 Obesity-related traits; CRC cis rs4363385 0.553 rs61813181 chr1:152942177 T/C cg25856811 chr1:152973957 SPRR3 -0.25 -6.59 -0.34 1.73e-10 Inflammatory skin disease; CRC cis rs2495707 0.647 rs1541266 chr10:102421292 C/T cg13834844 chr10:102415320 NA -0.34 -5.71 -0.3 2.57e-8 Body mass index; CRC cis rs738322 0.967 rs4383 chr22:38570927 C/G cg25457927 chr22:38595422 NA -0.35 -7.4 -0.38 1.13e-12 Cutaneous nevi; CRC cis rs877282 0.755 rs11253399 chr10:790030 T/A cg17470449 chr10:769945 NA 0.47 6.52 0.34 2.71e-10 Uric acid levels; CRC cis rs9443645 0.901 rs9352667 chr6:79572296 A/G cg05283184 chr6:79620031 NA 0.57 9.11 0.45 8.4e-18 Intelligence (multi-trait analysis); CRC cis rs12908161 0.959 rs11637728 chr15:85203392 A/T cg17507749 chr15:85114479 UBE2QP1 0.6 8.38 0.42 1.52e-15 Schizophrenia; CRC cis rs10504229 1.000 rs17216648 chr8:58169429 C/T cg01721255 chr8:58191610 C8orf71 0.47 5.97 0.31 6.02e-9 Developmental language disorder (linguistic errors); CRC cis rs2276314 1.000 rs9956938 chr18:33567061 A/G cg05985134 chr18:33552581 C18orf21 0.44 5.96 0.31 6.51e-9 Endometriosis;Drug-induced torsades de pointes; CRC cis rs807669 0.505 rs2236759 chr22:19187427 C/G cg02655711 chr22:19163373 SLC25A1 0.54 8.85 0.44 5.54e-17 Metabolite levels; CRC cis rs3008870 0.755 rs4486425 chr1:67460791 T/C cg08660285 chr1:67390436 MIER1;WDR78 -0.55 -7.69 -0.39 1.72e-13 Lymphocyte percentage of white cells; CRC cis rs4713118 0.516 rs7739216 chr6:28079946 G/T cg03623178 chr6:28175578 NA 0.95 12.14 0.56 2.76e-28 Parkinson's disease; CRC cis rs9640161 0.663 rs1916932 chr7:150021644 T/C cg13722127 chr7:150037890 RARRES2 0.47 7.66 0.39 2.07e-13 Blood protein levels;Circulating chemerin levels; CRC cis rs524023 0.874 rs492175 chr11:64433078 A/G cg06522879 chr11:64358276 SLC22A12 0.5 7.6 0.39 3.21e-13 Urate levels in obese individuals; CRC cis rs6032067 0.777 rs13039211 chr20:43784396 C/T cg10761708 chr20:43804764 PI3 0.48 5.62 0.3 4.06e-8 Blood protein levels; CRC cis rs7727544 0.735 rs2569266 chr5:131706791 T/C cg04518342 chr5:131593106 PDLIM4 -0.32 -5.66 -0.3 3.21e-8 Blood metabolite levels; CRC cis rs11958404 0.932 rs72816542 chr5:157416402 C/T cg05962755 chr5:157440814 NA 1.01 12.45 0.57 1.96e-29 IgG glycosylation; CRC cis rs947211 0.898 rs1772156 chr1:205752894 T/C cg11965913 chr1:205819406 PM20D1 0.41 5.8 0.3 1.59e-8 Parkinson's disease; CRC cis rs7613875 0.654 rs3774751 chr3:50209053 G/T cg05623727 chr3:50126028 RBM5 -0.35 -5.68 -0.3 3e-8 Body mass index; CRC cis rs7527798 0.614 rs11118253 chr1:207825469 G/C cg21110645 chr1:207815933 NA -0.39 -6.18 -0.32 1.9e-9 Erythrocyte sedimentation rate; CRC cis rs9322193 0.962 rs2342764 chr6:150156204 G/A cg13206674 chr6:150067644 NUP43 0.64 8.84 0.44 6.03e-17 Lung cancer; CRC cis rs1153858 1.000 rs16942000 chr15:45633003 C/T cg10760299 chr15:45669010 GATM 0.49 7.83 0.4 6.7e-14 Homoarginine levels; CRC cis rs738322 0.967 rs6001038 chr22:38570585 A/G cg17652424 chr22:38574118 PLA2G6 -0.22 -6.73 -0.35 7.71e-11 Cutaneous nevi; CRC cis rs3823572 0.542 rs2971971 chr7:133643848 A/G cg03336402 chr7:133662267 EXOC4 -0.66 -10.2 -0.49 2.07e-21 Intelligence (multi-trait analysis); CRC cis rs887829 0.641 rs10179094 chr2:234597825 T/A cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.45 -6.66 -0.34 1.12e-10 Metabolic traits;Bilirubin levels;Cholelithiasis-related traits in sickle cell anemia;Metabolite levels;Total bilirubin levels in HIV-1 infection;Serum metabolite levels;Blood metabolite levels; CRC cis rs4664293 0.867 rs3764968 chr2:160647090 C/T cg08347373 chr2:160653686 CD302 -0.51 -7.97 -0.4 2.62e-14 Monocyte percentage of white cells; CRC cis rs7927592 0.956 rs12274114 chr11:68255577 A/C cg01657329 chr11:68192670 LRP5 -0.46 -6.74 -0.35 7.19e-11 Total body bone mineral density; CRC cis rs2249694 0.878 rs2480256 chr10:135352514 A/G cg16964102 chr10:135390573 NA -0.39 -6.41 -0.33 5.19e-10 Obesity-related traits; CRC cis rs11148252 0.538 rs9535879 chr13:52704624 T/A cg00495681 chr13:53174319 NA 0.64 9.57 0.47 2.67e-19 Lewy body disease; CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg22428961 chr1:2344426 PEX10 0.38 6.36 0.33 6.61e-10 Obesity-related traits; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg11059266 chr4:48782139 FRYL 0.38 6.4 0.33 5.47e-10 Liver disease severity in Alagille syndrome; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg09610735 chr10:22609918 BMI1 0.44 6.19 0.32 1.77e-9 Response to antipsychotic treatment; CRC cis rs9648716 1.000 rs1267612 chr7:140511760 C/T cg10747023 chr7:140774559 NA 0.45 5.86 0.31 1.14e-8 Type 2 diabetes; CRC cis rs10504229 0.728 rs17804750 chr8:58155751 T/C cg08219700 chr8:58056026 NA 0.45 5.74 0.3 2.11e-8 Developmental language disorder (linguistic errors); CRC cis rs7107174 1.000 rs2510035 chr11:77953175 A/C cg02023728 chr11:77925099 USP35 0.51 7.4 0.38 1.12e-12 Testicular germ cell tumor; CRC cis rs7258465 1.000 rs4808134 chr19:18608579 G/A cg01065977 chr19:18549689 ISYNA1 -0.41 -6.43 -0.33 4.42e-10 Breast cancer; CRC cis rs9648716 1.000 rs6464157 chr7:140629408 T/C cg10747023 chr7:140774559 NA 0.46 6.02 0.31 4.76e-9 Type 2 diabetes; CRC cis rs995000 0.895 rs597470 chr1:62917796 T/G cg19896129 chr1:63156450 NA 0.44 6.81 0.35 4.71e-11 Triglyceride levels; CRC trans rs1455244 0.700 rs7229302 chr18:11508904 G/T cg22913584 chr5:81046758 SSBP2 0.4 6.06 0.32 3.63e-9 Schizophrenia; CRC cis rs72945132 0.882 rs59398290 chr11:70134819 G/A cg14191688 chr11:70257035 CTTN 0.4 5.62 0.3 4.07e-8 Coronary artery disease; CRC cis rs3785574 0.927 rs2854160 chr17:61977248 C/T cg06873352 chr17:61820015 STRADA 0.45 6.82 0.35 4.5e-11 Height; CRC cis rs7617480 0.648 rs9284885 chr3:48883100 A/C cg20833759 chr3:49053208 WDR6;DALRD3 0.67 11.05 0.52 2.36e-24 Subjective well-being (multi-trait analysis);Menarche (age at onset); CRC cis rs4072705 0.646 rs4838187 chr9:127242076 G/C cg13476313 chr9:127244764 NR5A1 0.29 6.06 0.32 3.83e-9 Menarche (age at onset); CRC cis rs7625357 0.964 rs1421005 chr3:169351777 C/T cg04414509 chr3:169351419 MECOM 0.63 8.97 0.44 2.34e-17 Childhood and early adolescence aggressive behavior; CRC cis rs10791097 0.694 rs4937583 chr11:130741606 A/G cg12179176 chr11:130786555 SNX19 0.75 12.66 0.57 3.28e-30 Autism spectrum disorder or schizophrenia;Schizophrenia; CRC cis rs17401966 1.000 rs12407992 chr1:10311983 A/C cg19773385 chr1:10388646 KIF1B -0.55 -7.58 -0.39 3.49e-13 Hepatocellular carcinoma; CRC cis rs6951245 1.000 rs28379681 chr7:1070539 C/T cg21664854 chr7:1097933 C7orf50;GPR146 0.79 8.92 0.44 3.39e-17 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC trans rs10504229 0.861 rs116923397 chr8:58185162 T/G cg04077850 chr5:125800366 GRAMD3 0.38 6.3 0.33 9.3e-10 Developmental language disorder (linguistic errors); CRC cis rs5769765 0.773 rs9616391 chr22:50314573 C/T cg02269571 chr22:50332266 NA -0.69 -8.83 -0.44 6.35e-17 Schizophrenia; CRC cis rs457287 0.772 rs10974799 chr9:4818453 G/C cg14182974 chr9:4791918 RCL1 -0.42 -5.62 -0.3 4.12e-8 Platelet count; CRC cis rs2797160 1.000 rs1739347 chr6:126014157 C/T cg05901451 chr6:126070800 HEY2 0.39 6.06 0.32 3.8e-9 Endometrial cancer; CRC cis rs12024301 0.557 rs10911409 chr1:183660804 T/G cg11505048 chr1:183622726 RGL1;APOBEC4 0.71 6.24 0.33 1.33e-9 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs875971 0.862 rs3893216 chr7:65790707 G/C cg12463550 chr7:65579703 CRCP -0.49 -6.59 -0.34 1.75e-10 Aortic root size; CRC trans rs2736345 0.502 rs12680762 chr8:11332026 A/G cg06636001 chr8:8085503 FLJ10661 -0.48 -6.03 -0.32 4.46e-9 Sjögren's syndrome;Systemic lupus erythematosus; CRC cis rs68170813 0.559 rs12537011 chr7:107027833 G/A cg02696742 chr7:106810147 HBP1 -0.59 -6.22 -0.32 1.52e-9 Coronary artery disease; CRC cis rs3768617 1.000 rs3768617 chr1:183092500 C/T ch.1.3577855R chr1:183094577 LAMC1 0.56 8.42 0.42 1.19e-15 Fuchs's corneal dystrophy; CRC cis rs6952808 0.798 rs28970524 chr7:1927484 C/T cg04267008 chr7:1944627 MAD1L1 -0.84 -12.6 -0.57 5.51e-30 Bipolar disorder and schizophrenia; CRC trans rs208515 0.518 rs12209790 chr6:66662965 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.93 11.75 0.54 7.56e-27 Exhaled nitric oxide levels; CRC cis rs3820068 0.655 rs59605679 chr1:15863796 T/G cg27534772 chr1:16042836 PLEKHM2 0.42 7.03 0.36 1.23e-11 Systolic blood pressure; CRC cis rs2404602 0.647 rs11072620 chr15:77048770 T/A cg03037974 chr15:76606532 NA -0.57 -8.77 -0.44 1.01e-16 Blood metabolite levels; CRC cis rs79349575 0.721 rs9904645 chr17:46969665 A/T cg00947319 chr17:47005597 UBE2Z -0.34 -5.83 -0.31 1.36e-8 Type 2 diabetes; CRC trans rs2243480 1.000 rs2462569 chr7:65474846 C/T cg10756647 chr7:56101905 PSPH -0.72 -8.08 -0.41 1.28e-14 Diabetic kidney disease; CRC cis rs6964587 0.626 rs7785941 chr7:91531024 T/C cg17063962 chr7:91808500 NA -0.58 -9.14 -0.45 6.68e-18 Breast cancer; CRC trans rs7302981 1.000 rs7302981 chr12:50537815 A/G cg18430156 chr2:187558795 FAM171B 0.35 6.02 0.31 4.72e-9 Systolic blood pressure; CRC cis rs6142102 0.923 rs3787230 chr20:32640272 A/G cg08999081 chr20:33150536 PIGU 0.37 5.83 0.31 1.33e-8 Skin pigmentation; CRC cis rs13336428 0.730 rs28653458 chr16:1525850 T/C cg08008072 chr16:1524255 CLCN7 -0.67 -13.37 -0.59 7.04e-33 Bone mineral density; CRC cis rs7927592 0.956 rs55816191 chr11:68262979 G/T cg16797656 chr11:68205561 LRP5 0.4 6.74 0.35 6.91e-11 Total body bone mineral density; CRC trans rs79243044 0.786 rs16932549 chr11:5560909 C/T cg08744461 chr12:108079556 PWP1 -0.43 -6.08 -0.32 3.24e-9 QRS duration in Tripanosoma cruzi seropositivity; CRC trans rs875971 0.660 rs2191268 chr7:66110224 C/T cg03341697 chr11:94277138 FUT4 -0.39 -5.98 -0.31 5.84e-9 Aortic root size; CRC trans rs7395662 0.622 rs2865620 chr11:48807911 C/T cg21153622 chr11:89784906 NA -0.48 -7.73 -0.39 1.35e-13 HDL cholesterol; CRC trans rs6686842 1.000 rs213733 chr1:41576989 T/C cg19787969 chr8:9763211 NA 0.28 5.97 0.31 6.03e-9 Height; CRC cis rs2354432 0.607 rs59606861 chr1:146761478 G/A cg25205988 chr1:146714368 CHD1L -1.15 -9.25 -0.45 2.98e-18 Mitochondrial DNA levels; CRC trans rs7618501 0.633 rs2883057 chr3:49998282 C/T cg21659725 chr3:3221576 CRBN 0.6 9.3 0.46 2.07e-18 Intelligence (multi-trait analysis); CRC cis rs2811415 0.597 rs1042912 chr3:127789695 C/T cg13719885 chr3:127795394 NA -0.39 -5.95 -0.31 6.69e-9 Lung function (FEV1/FVC); CRC cis rs9361491 0.657 rs4706730 chr6:79467903 C/T cg05283184 chr6:79620031 NA -0.37 -5.67 -0.3 3.16e-8 Intelligence (multi-trait analysis); CRC cis rs9311474 0.652 rs614288 chr3:52220203 T/C cg15147215 chr3:52552868 STAB1 -0.44 -7.2 -0.37 4.12e-12 Electroencephalogram traits; CRC cis rs755249 0.567 rs60323161 chr1:39710459 T/C cg18385671 chr1:39797026 MACF1 -0.44 -6.09 -0.32 3.08e-9 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs1552244 1.000 rs67006488 chr3:10152993 T/C cg02579736 chr3:10068473 FANCD2;CIDECP 1.03 13.67 0.6 5.38e-34 Alzheimer's disease; CRC cis rs9341808 0.754 rs9343973 chr6:80913216 A/G cg08355045 chr6:80787529 NA 0.43 6.94 0.36 2.08e-11 Sitting height ratio; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg08575399 chr20:60719638 PSMA7;SS18L1 0.5 7.11 0.36 7.13e-12 Response to antipsychotic treatment; CRC cis rs6546324 0.625 rs4671812 chr2:67832486 C/T cg15745817 chr2:67799979 NA -0.57 -9.64 -0.47 1.6e-19 Endometriosis; CRC cis rs11122272 0.706 rs2749710 chr1:231535112 A/C cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX 0.61 9.29 0.46 2.23e-18 Hemoglobin concentration; CRC cis rs2354432 0.556 rs2353977 chr1:146839637 G/T cg25205988 chr1:146714368 CHD1L 1.15 9.97 0.48 1.26e-20 Mitochondrial DNA levels; CRC cis rs1008375 1.000 rs28501187 chr4:17643620 G/A cg02297831 chr4:17616191 MED28 0.46 6.15 0.32 2.19e-9 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs10540 1.000 rs61876336 chr11:489537 C/T cg08200582 chr11:442649 ANO9 -0.7 -7.07 -0.36 9.14e-12 Body mass index; CRC cis rs12477438 0.501 rs7608938 chr2:99782226 C/T cg26064155 chr2:99771622 LIPT1;TSGA10 0.77 13.13 0.59 5.79e-32 Chronic sinus infection; CRC cis rs73206853 0.841 rs73191851 chr12:111032305 G/A cg12870014 chr12:110450643 ANKRD13A 0.81 8.35 0.42 1.95e-15 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC cis rs6951245 0.554 rs79367977 chr7:1152657 G/A cg03188948 chr7:1209495 NA 0.54 6.43 0.33 4.58e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs9372498 0.536 rs7356947 chr6:118767920 A/G cg24463073 chr6:118973353 C6orf204 0.51 6.81 0.35 4.71e-11 Diastolic blood pressure; CRC cis rs34779708 0.966 rs4934725 chr10:35398236 T/C cg03585969 chr10:35415529 CREM 0.66 8.73 0.43 1.33e-16 Inflammatory bowel disease;Crohn's disease; CRC cis rs1003719 0.591 rs2018521 chr21:38517264 A/G cg10648535 chr21:38446584 PIGP;TTC3 -0.42 -5.82 -0.31 1.37e-8 Eye color traits; CRC cis rs6570726 0.791 rs1280276 chr6:145892350 A/C cg13319975 chr6:146136371 FBXO30 -0.44 -6.41 -0.33 4.93e-10 Lobe attachment (rater-scored or self-reported); CRC cis rs7954584 0.626 rs10840637 chr12:122427310 A/G cg21171335 chr12:122356390 WDR66 0.39 5.99 0.31 5.56e-9 Mean corpuscular volume; CRC cis rs514406 0.893 rs1242330 chr1:53396842 T/G cg25767906 chr1:53392781 SCP2 -0.5 -8.04 -0.41 1.62e-14 Monocyte count; CRC cis rs344364 0.518 rs1657129 chr16:1945826 G/A cg00046913 chr16:1877150 HAGH;FAHD1 -0.56 -5.92 -0.31 7.93e-9 Glomerular filtration rate in chronic kidney disease; CRC cis rs12188164 0.515 rs11745246 chr5:410943 A/G cg17553881 chr5:443987 EXOC3;C5orf55 -0.32 -6.5 -0.34 2.9e-10 Cystic fibrosis severity; CRC cis rs10504229 1.000 rs117231141 chr8:58185465 A/G cg24829409 chr8:58192753 C8orf71 -0.68 -11.34 -0.53 2.27e-25 Developmental language disorder (linguistic errors); CRC cis rs3806843 0.576 rs246041 chr5:140331128 C/G cg19875535 chr5:140030758 IK 0.4 6.12 0.32 2.64e-9 Depressive symptoms (multi-trait analysis); CRC trans rs6544773 0.630 rs2673281 chr2:45065355 G/A cg10208897 chr5:178548229 ADAMTS2 0.35 6.0 0.31 5.08e-9 Mosquito bite size; CRC trans rs3942852 0.806 rs1875696 chr11:48133526 G/A cg15704280 chr7:45808275 SEPT13 -0.61 -7.8 -0.4 8.26e-14 Acute lymphoblastic leukemia (childhood); CRC cis rs6952808 1.000 rs4721122 chr7:1893311 C/G cg21782813 chr7:2030301 MAD1L1 0.41 7.07 0.36 9.12e-12 Bipolar disorder and schizophrenia; CRC cis rs4713118 0.824 rs9468225 chr6:27745719 T/G cg20933634 chr6:27740509 NA 0.64 8.8 0.44 7.72e-17 Parkinson's disease; CRC cis rs10782582 0.569 rs74090722 chr1:76197262 A/G cg10523679 chr1:76189770 ACADM -0.42 -6.08 -0.32 3.4e-9 Daytime sleep phenotypes; CRC cis rs7412746 0.611 rs2864873 chr1:150814174 A/G cg18016565 chr1:150552671 MCL1 0.43 6.0 0.31 5.13e-9 Melanoma; CRC cis rs9322817 0.653 rs9399896 chr6:105216969 A/G cg02098413 chr6:105308735 HACE1 -0.44 -8.51 -0.42 6.37e-16 Thyroid stimulating hormone; CRC trans rs7873102 0.702 rs7028020 chr9:38007747 C/T cg27470027 chr11:63684601 RCOR2 -0.36 -6.48 -0.34 3.43e-10 Brain structure; CRC cis rs769267 0.896 rs2315610 chr19:19597240 T/C cg02546618 chr19:19431379 KIAA0892;SF4 0.45 6.19 0.32 1.78e-9 Tonsillectomy; CRC cis rs6427782 0.582 rs6695240 chr1:199833586 G/A cg07208853 chr1:200005219 NR5A2 0.23 5.94 0.31 7.13e-9 Menarche (age at onset); CRC cis rs11155671 0.530 rs9383912 chr6:150206615 T/C cg19673125 chr6:150240577 RAET1G 0.29 5.63 0.3 3.82e-8 Testicular germ cell tumor; CRC cis rs79839061 0.610 rs3775122 chr4:893287 A/G cg14530993 chr4:882597 GAK -0.82 -7.8 -0.4 8.31e-14 Intelligence (multi-trait analysis); CRC cis rs4713118 0.824 rs13211701 chr6:27750079 T/C cg26587870 chr6:27730563 NA -0.45 -6.55 -0.34 2.18e-10 Parkinson's disease; CRC cis rs1005277 0.579 rs2472174 chr10:38375382 A/G cg00409905 chr10:38381863 ZNF37A -0.67 -11.24 -0.53 5.14e-25 Extrinsic epigenetic age acceleration; CRC cis rs7769051 1.000 rs9493438 chr6:133098349 T/C cg22852734 chr6:133119734 C6orf192 0.93 11.01 0.52 3.31e-24 Type 2 diabetes nephropathy; CRC cis rs4862750 0.872 rs6852907 chr4:187897094 A/C cg10295955 chr4:187884368 NA -1.06 -28.15 -0.84 1.27e-89 Lobe attachment (rater-scored or self-reported); CRC cis rs7659604 0.676 rs6534323 chr4:122695888 G/A cg19748678 chr4:122722346 EXOSC9 0.67 10.73 0.51 3.13e-23 Type 2 diabetes; CRC cis rs2153535 0.580 rs9406174 chr6:8516764 T/C cg07606381 chr6:8435919 SLC35B3 0.65 10.56 0.5 1.24e-22 Motion sickness; CRC cis rs13191362 1.000 rs35126854 chr6:163012443 C/T cg06582575 chr6:163149167 PACRG;PARK2 0.71 10.22 0.49 1.72e-21 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs936229 0.813 rs7085 chr15:75095483 T/C cg14664628 chr15:75095509 CSK -1.05 -21.32 -0.76 5.87e-64 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); CRC cis rs270601 0.837 rs367805 chr5:131701279 T/C cg02033258 chr5:131593261 PDLIM4 0.38 6.39 0.33 5.51e-10 Acylcarnitine levels; CRC cis rs2032447 0.867 rs9295683 chr6:26069495 C/T cg27635394 chr6:26043820 HIST1H2BB 0.38 5.73 0.3 2.21e-8 Intelligence (multi-trait analysis); CRC cis rs2245008 0.774 rs253136 chr16:83979601 A/C cg07978099 chr16:83986941 OSGIN1 -0.48 -6.1 -0.32 3.05e-9 Pursuit maintenance gain; CRC cis rs9611565 0.649 rs79005 chr22:41835544 G/A cg06634786 chr22:41940651 POLR3H 0.55 6.71 0.35 8.44e-11 Vitiligo; CRC cis rs7254114 0.686 rs7249565 chr19:11302807 C/T cg02815516 chr19:11306319 KANK2 -0.36 -7.07 -0.36 9.33e-12 Immature fraction of reticulocytes; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg09695362 chr17:43324895 LOC100133991 0.41 6.65 0.34 1.23e-10 Liver disease severity in Alagille syndrome; CRC cis rs1670533 1.000 rs7673898 chr4:1056569 C/A cg27284194 chr4:1044797 NA 0.5 6.2 0.32 1.66e-9 Recombination rate (females); CRC cis rs728616 0.867 rs61860400 chr10:81723427 T/C cg11900509 chr10:81946545 ANXA11 -0.68 -6.82 -0.35 4.39e-11 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs11122272 0.735 rs2749709 chr1:231530476 G/T cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.56 -8.43 -0.42 1.08e-15 Hemoglobin concentration; CRC trans rs11722228 0.549 rs56146302 chr4:10081052 C/T cg26043149 chr18:55253948 FECH 1.13 17.09 0.69 2.61e-47 Gout;Urate levels;Serum uric acid levels; CRC cis rs2228479 0.764 rs7184960 chr16:89961661 C/T cg06656553 chr16:89960601 TCF25 -0.55 -5.7 -0.3 2.62e-8 Skin colour saturation; CRC cis rs861020 0.527 rs614662 chr1:209962419 C/T cg23283495 chr1:209979779 IRF6 -0.32 -5.84 -0.31 1.23e-8 Orofacial clefts; CRC cis rs2739330 0.761 rs5760176 chr22:24402321 A/G cg09033563 chr22:24373618 LOC391322 0.49 7.29 0.37 2.29e-12 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs3749237 0.615 rs11130202 chr3:49566715 C/T cg02487422 chr3:49467188 NICN1 0.43 6.94 0.36 2.1e-11 Resting heart rate; CRC cis rs6504622 0.818 rs11079742 chr17:45020128 A/G cg16759221 chr17:45003025 GOSR2 0.49 7.4 0.38 1.17e-12 Orofacial clefts; CRC cis rs12142240 0.731 rs12385693 chr1:46818921 A/C cg14993813 chr1:46806288 NSUN4 -0.49 -6.18 -0.32 1.94e-9 Menopause (age at onset); CRC trans rs1005277 0.557 rs1854563 chr10:38434961 G/A cg27523141 chr10:43048294 ZNF37B 0.49 7.13 0.37 6.4e-12 Extrinsic epigenetic age acceleration; CRC cis rs6502050 0.764 rs28676462 chr17:80105100 G/C cg22110888 chr17:80059540 CCDC57 0.4 6.44 0.33 4.17e-10 Life satisfaction; CRC cis rs2032447 0.772 rs199754 chr6:25992309 A/G cg18357526 chr6:26021779 HIST1H4A 0.8 11.91 0.55 1.92e-27 Intelligence (multi-trait analysis); CRC cis rs7666738 0.830 rs10022389 chr4:99022229 T/C cg05340658 chr4:99064831 C4orf37 0.61 9.51 0.46 4.05e-19 Colonoscopy-negative controls vs population controls; CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg08180952 chr15:75744002 SIN3A 0.4 6.42 0.33 4.69e-10 Obesity-related traits; CRC cis rs6952808 1.000 rs4601204 chr7:1890925 C/T cg00106254 chr7:1943704 MAD1L1 -0.45 -6.43 -0.33 4.47e-10 Bipolar disorder and schizophrenia; CRC cis rs10450586 0.932 rs7480595 chr11:27316623 T/C cg10370305 chr11:27303972 NA 0.35 5.69 0.3 2.76e-8 Total body bone mineral density; CRC cis rs2046867 0.908 rs62251654 chr3:72816488 C/T cg25664220 chr3:72788482 NA -0.46 -6.39 -0.33 5.6e-10 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; CRC cis rs1552244 0.872 rs6792951 chr3:10119603 C/A cg02579736 chr3:10068473 FANCD2;CIDECP 0.96 13.0 0.58 1.85e-31 Alzheimer's disease; CRC cis rs72781680 0.898 rs7563564 chr2:23993404 T/C cg08917208 chr2:24149416 ATAD2B 0.87 8.46 0.42 8.88e-16 Lymphocyte counts; CRC cis rs4332037 0.539 rs11764780 chr7:2020904 G/C cg24505167 chr7:1915268 MAD1L1 -0.46 -6.42 -0.33 4.77e-10 Bipolar disorder; CRC cis rs2243480 1.000 rs313820 chr7:65574466 A/C cg25985355 chr7:65971099 NA -0.49 -5.73 -0.3 2.27e-8 Diabetic kidney disease; CRC trans rs853679 0.599 rs188015 chr6:27877446 T/A cg06606381 chr12:133084897 FBRSL1 -0.8 -7.28 -0.37 2.48e-12 Depression; CRC cis rs4665809 0.793 rs6546715 chr2:26261520 G/A cg26119090 chr2:26468346 HADHA;HADHB -0.61 -7.96 -0.4 2.87e-14 Gut microbiome composition (summer); CRC cis rs2050392 0.861 rs1042058 chr10:30728101 T/C cg18806716 chr10:30721971 MAP3K8 -0.5 -7.5 -0.38 5.82e-13 Inflammatory bowel disease; CRC cis rs977987 0.806 rs12930768 chr16:75464500 T/C cg03315344 chr16:75512273 CHST6 0.55 9.12 0.45 7.56e-18 Dupuytren's disease; CRC trans rs9929218 0.953 rs28608872 chr16:68802038 A/G cg04657470 chr2:198365150 HSPE1;HSPD1 -0.83 -11.86 -0.55 2.96e-27 Colorectal cancer; CRC cis rs12142240 0.659 rs111723629 chr1:46853361 G/T cg00530320 chr1:46809349 NSUN4 0.59 8.07 0.41 1.35e-14 Menopause (age at onset); CRC cis rs7615952 0.576 rs2276727 chr3:125826243 C/T cg18479299 chr3:125709523 NA -0.55 -6.64 -0.34 1.3e-10 Blood pressure (smoking interaction); CRC cis rs9916302 0.752 rs676882 chr17:37433424 A/T cg00129232 chr17:37814104 STARD3 0.52 6.42 0.33 4.77e-10 Glomerular filtration rate (creatinine); CRC cis rs7666738 0.791 rs2081621 chr4:98926753 C/A cg17366294 chr4:99064904 C4orf37 0.43 7.32 0.37 1.95e-12 Colonoscopy-negative controls vs population controls; CRC cis rs807029 0.577 rs11190787 chr10:102758625 G/T cg04662943 chr10:102668895 NA 0.58 6.93 0.36 2.17e-11 Ejection fraction in Tripanosoma cruzi seropositivity; CRC cis rs6662572 0.737 rs4388641 chr1:46522326 A/C cg08644498 chr1:46502608 NA 0.45 7.14 0.37 6.01e-12 Blood protein levels; CRC cis rs2153535 0.580 rs2152347 chr6:8474281 A/G cg21535247 chr6:8435926 SLC35B3 0.49 7.4 0.38 1.14e-12 Motion sickness; CRC cis rs1348850 0.914 rs4893938 chr2:178250095 T/C cg02961200 chr2:178257176 LOC100130691;AGPS 0.61 9.05 0.45 1.25e-17 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs2979489 0.891 rs2979508 chr8:30388444 C/T cg26383811 chr8:30366931 RBPMS -0.71 -10.61 -0.5 8.0700000000000006e-23 Mean corpuscular hemoglobin;Plateletcrit;Neutrophil count;Granulocyte count;Sum basophil neutrophil counts;Mean corpuscular volume;Myeloid white cell count;Sum neutrophil eosinophil counts; CRC cis rs7731657 0.537 rs971700 chr5:130361575 T/G cg08523029 chr5:130500466 HINT1 -0.47 -6.02 -0.31 4.67e-9 Fasting plasma glucose; CRC cis rs12291225 0.585 rs12270374 chr11:14375079 T/C cg05501817 chr11:14380813 RRAS2 -0.47 -6.52 -0.34 2.59e-10 Sense of smell; CRC cis rs6460942 0.915 rs1595802 chr7:12439672 C/T cg06484146 chr7:12443880 VWDE -0.8 -8.55 -0.43 4.58e-16 Coronary artery disease; CRC cis rs898097 1.000 rs898098 chr17:80904564 G/A cg19046167 chr17:80928561 B3GNTL1 0.4 6.36 0.33 6.66e-10 Breast cancer; CRC cis rs1552244 1.000 rs6807846 chr3:10134491 G/T cg18598329 chr3:10140678 FANCD2;C3orf24 -0.91 -13.02 -0.58 1.56e-31 Alzheimer's disease; CRC cis rs2070488 0.804 rs13092539 chr3:38458725 G/A cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.78 13.2 0.59 3.13e-32 Electrocardiographic conduction measures; CRC cis rs1552244 0.816 rs9847657 chr3:10173492 G/T cg13047869 chr3:10149882 C3orf24 0.44 6.51 0.34 2.82e-10 Alzheimer's disease; CRC cis rs10504229 0.565 rs7010503 chr8:58147127 G/A cg02290350 chr8:58132656 NA -0.53 -7.86 -0.4 5.64e-14 Developmental language disorder (linguistic errors); CRC cis rs4936891 0.577 rs4935862 chr11:123921479 C/T cg22125253 chr11:123886957 OR10G4 0.33 6.04 0.32 4.2e-9 Male fertility; CRC cis rs11031096 0.621 rs11031159 chr11:4179695 T/G cg18678763 chr11:4115507 RRM1 -0.36 -5.79 -0.3 1.68e-8 Mean corpuscular volume;Mean corpuscular hemoglobin; CRC cis rs1552244 0.882 rs6443276 chr3:10008905 C/A cg00166722 chr3:10149974 C3orf24 0.61 8.13 0.41 9.08e-15 Alzheimer's disease; CRC cis rs8180040 0.726 rs4682844 chr3:46982737 T/C cg27129171 chr3:47204927 SETD2 -0.74 -11.47 -0.53 7.33e-26 Colorectal cancer; CRC cis rs8072100 0.871 rs7206971 chr17:45425115 A/G cg25173405 chr17:45401733 C17orf57 0.51 8.29 0.42 3.01e-15 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC trans rs6956675 0.830 rs4585626 chr7:62671592 C/G cg01314568 chr7:57830625 NA 0.64 8.47 0.42 8.08e-16 Obesity-related traits; CRC cis rs76878669 0.561 rs12794121 chr11:66126169 G/T cg18002602 chr11:66138449 SLC29A2 0.28 6.13 0.32 2.55e-9 Educational attainment (years of education); CRC cis rs600806 0.850 rs10776806 chr1:109952127 G/A cg23032129 chr1:109941072 SORT1 -0.28 -5.94 -0.31 7.09e-9 Intelligence (multi-trait analysis); CRC cis rs9650657 0.538 rs6984496 chr8:10796093 G/T cg27411982 chr8:10470053 RP1L1 -0.38 -5.96 -0.31 6.58e-9 Neuroticism; CRC cis rs5769765 0.862 rs9616381 chr22:50312382 G/A cg04121214 chr22:50244548 NA 0.42 5.89 0.31 9.4e-9 Schizophrenia; CRC cis rs2032447 0.899 rs1090947 chr6:26076642 T/C cg17691542 chr6:26056736 HIST1H1C 0.41 5.79 0.3 1.67e-8 Intelligence (multi-trait analysis); CRC cis rs6429082 0.510 rs2789367 chr1:235506918 G/C cg26050004 chr1:235667680 B3GALNT2 0.4 5.86 0.31 1.11e-8 Adiposity; CRC cis rs4713118 0.513 rs149878 chr6:27878738 T/G cg15845792 chr6:28175446 NA 0.79 11.81 0.55 4.37e-27 Parkinson's disease; CRC cis rs8060686 0.668 rs9932414 chr16:68219969 A/G cg26727032 chr16:67993705 SLC12A4 -0.6 -9.49 -0.46 4.8e-19 HDL cholesterol;Metabolic syndrome; CRC cis rs2070677 1.000 rs1329149 chr10:135349801 T/C cg20169779 chr10:135381914 SYCE1 0.78 11.25 0.53 4.74e-25 Gout; CRC trans rs1814175 0.645 rs847630 chr11:49926360 C/T cg15704280 chr7:45808275 SEPT13 -0.95 -16.82 -0.68 3.11e-46 Height; CRC cis rs13108904 0.557 rs1680033 chr4:1243404 C/T cg24560729 chr4:1342394 KIAA1530 -0.34 -5.61 -0.3 4.2e-8 Obesity-related traits; CRC cis rs919433 0.680 rs788022 chr2:198280586 T/C cg10820045 chr2:198174542 NA 0.38 6.38 0.33 6.09e-10 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC cis rs9814567 0.964 rs9815894 chr3:134282796 C/G cg06541857 chr3:134203789 ANAPC13;CEP63 -0.4 -5.99 -0.31 5.53e-9 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC trans rs2547917 0.947 rs2591744 chr5:58715865 A/G cg15920655 chr2:129025795 HS6ST1 0.56 5.99 0.31 5.61e-9 Adverse response to chemotherapy (neutropenia/leucopenia) (gemcitabine); CRC cis rs7591163 1.000 rs7591163 chr2:228715375 C/T cg21577049 chr2:228736449 WDR69 -0.47 -6.28 -0.33 1.09e-9 Blood pressure; CRC cis rs1799949 1.000 rs11656097 chr17:41290613 G/T cg25072359 chr17:41440525 NA 0.46 6.97 0.36 1.79e-11 Menopause (age at onset); CRC cis rs2180341 0.521 rs12203812 chr6:127617816 A/T cg24812749 chr6:127587940 RNF146 0.48 6.77 0.35 5.93e-11 Breast cancer; CRC cis rs478222 0.930 rs510107 chr2:25319471 G/A cg22495460 chr2:25135724 ADCY3 0.43 6.47 0.34 3.64e-10 Type 1 diabetes; CRC cis rs7833790 1.000 rs7834808 chr8:82704996 A/G cg27398817 chr8:82754497 SNX16 -0.51 -6.0 -0.31 5.16e-9 Diastolic blood pressure; CRC cis rs7044106 0.762 rs1886337 chr9:123443776 G/C cg14255062 chr9:123606675 PSMD5;LOC253039 0.45 6.79 0.35 5.23e-11 Hip circumference adjusted for BMI; CRC cis rs17021463 0.676 rs62320932 chr4:95307037 C/T cg11021082 chr4:95130006 SMARCAD1 0.44 6.35 0.33 6.97e-10 Testicular germ cell tumor; CRC cis rs798554 0.679 rs1636250 chr7:2884433 T/C cg13628971 chr7:2884303 GNA12 0.61 8.3 0.42 2.72e-15 Height; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg12595990 chr12:49351331 ARF3 0.41 6.56 0.34 2.07e-10 Liver disease severity in Alagille syndrome; CRC cis rs1799949 0.965 rs9897425 chr17:41430179 C/G cg19454999 chr17:41278357 BRCA1;NBR2 0.39 6.06 0.32 3.67e-9 Menopause (age at onset); CRC cis rs938554 0.876 rs10017945 chr4:9937852 A/G cg00071950 chr4:10020882 SLC2A9 -0.41 -5.82 -0.31 1.4e-8 Blood metabolite levels; CRC cis rs11785400 1.000 rs11776301 chr8:143737142 A/G cg10596483 chr8:143751796 JRK 0.5 6.96 0.36 1.85e-11 Schizophrenia; CRC cis rs2227564 0.574 rs3849969 chr10:75525999 C/T cg16540259 chr10:75572220 NDST2 -0.52 -7.9 -0.4 4.3e-14 Crohn's disease;Inflammatory bowel disease; CRC cis rs853679 0.550 rs1233701 chr6:28168726 C/G cg21251018 chr6:28226885 NKAPL -0.45 -6.49 -0.34 3.18e-10 Depression; CRC cis rs7089973 0.668 rs7898347 chr10:116644324 G/A cg23260525 chr10:116636907 FAM160B1 0.35 7.75 0.39 1.16e-13 Bipolar disorder or attention deficit hyperactivity disorder; CRC trans rs9409565 0.826 rs639276 chr9:97206737 G/T cg05679027 chr9:99775184 HIATL2 -0.41 -6.15 -0.32 2.24e-9 Colorectal cancer (alcohol consumption interaction); CRC cis rs9926296 0.542 rs12599531 chr16:89909401 C/T cg04287289 chr16:89883240 FANCA -0.56 -8.55 -0.43 4.74e-16 Vitiligo; CRC cis rs820430 0.512 rs2120892 chr3:27249655 C/G cg02860705 chr3:27208620 NA 0.4 6.13 0.32 2.49e-9 Hypertension;Diastolic blood pressure;Systolic blood pressure; CRC cis rs3736485 0.966 rs8042221 chr15:51774613 A/G cg08986416 chr15:51914746 DMXL2 -0.44 -6.33 -0.33 7.97e-10 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC trans rs2303319 0.504 rs1449641 chr2:162619567 T/C cg22988483 chr14:93581567 ITPK1 -0.66 -6.08 -0.32 3.32e-9 Cognitive function; CRC cis rs7662987 0.517 rs4235436 chr4:100039620 G/A cg12011299 chr4:100065546 ADH4 0.49 9.26 0.45 2.63e-18 Smoking initiation; CRC cis rs9583531 0.760 rs1887200 chr13:111393137 A/C cg24331049 chr13:111365604 ING1 -0.5 -5.87 -0.31 1.04e-8 Coronary artery disease; CRC cis rs2976388 0.525 rs2016749 chr8:143836118 G/A cg15511327 chr8:143859410 LYNX1 -0.52 -9.14 -0.45 6.63e-18 Urinary tract infection frequency; CRC cis rs6570726 0.577 rs406868 chr6:145809983 C/T cg23711669 chr6:146136114 FBXO30 0.61 8.98 0.44 2.09e-17 Lobe attachment (rater-scored or self-reported); CRC cis rs9291683 0.507 rs6845554 chr4:10013173 T/G cg00071950 chr4:10020882 SLC2A9 0.62 11.19 0.52 7.8e-25 Bone mineral density; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg16532893 chr10:38146893 ZNF248 0.47 7.57 0.39 3.68e-13 Liver disease severity in Alagille syndrome; CRC cis rs1865721 0.771 rs7236311 chr18:73137450 A/G cg26385618 chr18:73139727 C18orf62 -0.39 -5.92 -0.31 7.88e-9 Intelligence; CRC cis rs860295 0.651 rs12239114 chr1:155322142 G/A cg02153340 chr1:155202674 NA -0.58 -6.88 -0.35 2.98e-11 Body mass index; CRC cis rs4713118 0.505 rs276371 chr6:27910708 A/T cg15786705 chr6:28176104 NA 0.42 5.87 0.31 1.04e-8 Parkinson's disease; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg05900430 chr19:48825159 NA 0.46 6.22 0.32 1.51e-9 Anxiety disorder; CRC cis rs11122272 0.735 rs2491404 chr1:231512127 C/T cg06096015 chr1:231504339 EGLN1 0.39 5.88 0.31 1.02e-8 Hemoglobin concentration; CRC cis rs863345 0.604 rs2051450 chr1:158464062 A/G cg12129480 chr1:158549410 OR10X1 -0.3 -6.26 -0.33 1.17e-9 Pneumococcal bacteremia; CRC cis rs798554 0.660 rs1182196 chr7:2866478 T/G cg13628971 chr7:2884303 GNA12 0.4 6.03 0.32 4.43e-9 Height; CRC cis rs3785574 0.962 rs2727324 chr17:61922102 G/C cg06601766 chr17:61851465 DDX42;CCDC47 0.54 7.52 0.38 5.36e-13 Height; CRC trans rs6550704 0.687 rs9865314 chr3:22634337 A/G cg18168387 chr12:120933482 DYNLL1 -0.41 -6.24 -0.33 1.31e-9 Daytime sleep phenotypes; CRC cis rs7937682 0.587 rs571594 chr11:111359334 A/G cg19812747 chr11:111475976 SIK2 0.43 6.6 0.34 1.66e-10 Primary sclerosing cholangitis; CRC cis rs9372498 0.505 rs62424202 chr6:118851027 T/C cg24463073 chr6:118973353 C6orf204 0.55 7.34 0.38 1.7e-12 Diastolic blood pressure; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg21218476 chr17:7117863 DLG4 0.37 6.02 0.31 4.61e-9 Liver disease severity in Alagille syndrome; CRC trans rs2228479 0.850 rs12597296 chr16:89822331 C/T cg24644049 chr4:85504048 CDS1 0.86 6.93 0.36 2.29e-11 Skin colour saturation; CRC cis rs4862750 0.914 rs1863405 chr4:187874528 G/T cg03647317 chr4:187891568 NA 0.54 10.26 0.49 1.27e-21 Lobe attachment (rater-scored or self-reported); CRC cis rs6570726 0.791 rs422099 chr6:145806936 C/T cg05347473 chr6:146136440 FBXO30 0.38 5.82 0.31 1.4e-8 Lobe attachment (rater-scored or self-reported); CRC cis rs2075371 0.933 rs1833475 chr7:133958263 C/T cg11752832 chr7:134001865 SLC35B4 0.44 6.72 0.35 8.13e-11 Mean platelet volume; CRC cis rs2228479 0.618 rs17233623 chr16:89811209 C/T cg06656553 chr16:89960601 TCF25 -0.63 -5.69 -0.3 2.79e-8 Skin colour saturation; CRC cis rs597539 0.652 rs514296 chr11:68654182 G/T cg04772025 chr11:68637568 NA 0.46 7.09 0.36 8.09e-12 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs240110 0.539 rs6919745 chr6:101338978 T/C cg09795085 chr6:101329169 ASCC3 0.49 6.83 0.35 4.03e-11 Neuroticism; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg17449403 chr12:48357323 TMEM106C 0.43 6.92 0.36 2.44e-11 Liver disease severity in Alagille syndrome; CRC cis rs2361718 0.500 rs8064429 chr17:78096187 A/C cg14949292 chr17:78079608 GAA -0.42 -6.04 -0.32 4.26e-9 Yeast infection; CRC cis rs4713118 0.597 rs172166 chr6:28020820 C/G cg18032046 chr6:28092343 ZSCAN16 -0.47 -6.07 -0.32 3.49e-9 Parkinson's disease; CRC cis rs7020830 0.858 rs7856690 chr9:37127545 A/T cg14294708 chr9:37120828 ZCCHC7 1.06 20.34 0.75 3.98e-60 Schizophrenia; CRC cis rs8067545 0.611 rs733794 chr17:20157957 T/C cg13482628 chr17:19912719 NA -0.48 -7.61 -0.39 2.96e-13 Schizophrenia; CRC cis rs6066835 0.867 rs16994110 chr20:47360830 T/C cg18078177 chr20:47281410 PREX1 0.61 5.6 0.3 4.46e-8 Multiple myeloma; CRC trans rs1997103 0.954 rs56030000 chr7:55405750 A/G cg20935933 chr6:143382018 AIG1 0.51 6.65 0.34 1.25e-10 QRS interval (sulfonylurea treatment interaction); CRC cis rs10504229 0.683 rs10504223 chr8:58140944 G/A cg21724239 chr8:58056113 NA 0.49 6.81 0.35 4.75e-11 Developmental language disorder (linguistic errors); CRC trans rs7267979 1.000 rs2500432 chr20:25290512 A/C cg17903999 chr18:56338584 MALT1 -0.43 -7.02 -0.36 1.25e-11 Liver enzyme levels (alkaline phosphatase); CRC cis rs2228479 0.850 rs17233567 chr16:89813821 G/A cg06656553 chr16:89960601 TCF25 -0.69 -5.74 -0.3 2.15e-8 Skin colour saturation; CRC cis rs1707322 1.000 rs34444543 chr1:46358862 G/A cg03146154 chr1:46216737 IPP 0.52 7.09 0.36 8.21e-12 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs7726839 0.561 rs4957048 chr5:583442 G/A cg14541582 chr5:601475 NA -0.32 -6.65 -0.34 1.22e-10 Obesity-related traits; CRC trans rs12714314 0.560 rs11694545 chr2:1939208 C/T cg05979741 chr2:110873485 MALL 0.47 6.17 0.32 2.03e-9 Type 2 diabetes (age of onset); CRC cis rs11122272 0.638 rs2739514 chr1:231514806 G/A cg06096015 chr1:231504339 EGLN1 0.41 6.05 0.32 4.03e-9 Hemoglobin concentration; CRC cis rs10504229 0.683 rs61306359 chr8:58134646 G/A cg22535103 chr8:58192502 C8orf71 -0.7 -9.34 -0.46 1.47e-18 Developmental language disorder (linguistic errors); CRC cis rs2075371 0.863 rs34231360 chr7:133944988 A/C cg02659138 chr7:134003124 SLC35B4 0.39 6.67 0.35 1.07e-10 Mean platelet volume; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg12820191 chr3:186524311 RFC4 0.38 6.13 0.32 2.49e-9 Liver disease severity in Alagille syndrome; CRC cis rs6586163 1.000 rs6586165 chr10:90755056 T/A cg03111039 chr10:90751583 FAS;ACTA2 -0.5 -7.29 -0.37 2.38e-12 Chronic lymphocytic leukemia; CRC cis rs76419734 0.510 rs2544402 chr4:106687733 A/G cg24545054 chr4:106630052 GSTCD;INTS12 -0.55 -6.28 -0.33 1.07e-9 Post bronchodilator FEV1; CRC trans rs9388451 0.626 rs9385383 chr6:126086290 G/T cg05039488 chr6:79577232 IRAK1BP1 -0.71 -12.04 -0.55 6.6e-28 Brugada syndrome; CRC cis rs6904897 0.563 rs4896117 chr6:135229400 T/C cg24558204 chr6:135376177 HBS1L -0.43 -6.17 -0.32 2.05e-9 Mean corpuscular volume;Mean corpuscular hemoglobin; CRC cis rs909002 0.849 rs10798879 chr1:32096815 T/C cg13919466 chr1:32135498 COL16A1 -0.32 -6.1 -0.32 2.99e-9 Intelligence (multi-trait analysis); CRC cis rs13118159 0.509 rs1882098 chr4:1352431 T/C cg02018176 chr4:1364513 KIAA1530 0.7 11.97 0.55 1.14e-27 Longevity; CRC trans rs2303319 0.504 rs72877343 chr2:162607487 A/C cg22922770 chr7:98923339 ARPC1A -0.67 -5.98 -0.31 5.68e-9 Cognitive function; CRC cis rs2932538 0.583 rs2932537 chr1:113230394 C/T cg22162597 chr1:113214053 CAPZA1 0.47 6.08 0.32 3.41e-9 Systolic blood pressure;Diastolic blood pressure;Hypertension;Blood pressure; CRC cis rs17125944 0.615 rs12586707 chr14:53298277 A/G cg00686598 chr14:53173677 PSMC6 -0.62 -5.96 -0.31 6.5e-9 Alzheimer's disease (late onset); CRC cis rs7312933 1.000 rs3229 chr12:42475888 G/A cg11827402 chr12:42719852 PPHLN1;ZCRB1 0.6 7.64 0.39 2.43e-13 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CRC cis rs4731207 0.596 rs1871772 chr7:124678872 G/T cg23710748 chr7:124431027 NA -0.4 -6.28 -0.33 1.09e-9 Cutaneous malignant melanoma; CRC trans rs7618501 0.633 rs2526748 chr3:50080439 A/G cg21665057 chr3:196295764 WDR53;FBXO45 -0.57 -9.07 -0.45 1.09e-17 Intelligence (multi-trait analysis); CRC cis rs1023500 0.505 rs134899 chr22:42683030 T/G cg04733989 chr22:42467013 NAGA 0.45 6.52 0.34 2.58e-10 Schizophrenia; CRC cis rs951366 0.789 rs823095 chr1:205679239 G/A cg24503407 chr1:205819492 PM20D1 0.81 12.09 0.55 4.19e-28 Menarche (age at onset); CRC cis rs12681287 0.640 rs7460650 chr8:87474085 A/G cg27223183 chr8:87520930 FAM82B -0.5 -7.18 -0.37 4.69e-12 Caudate activity during reward; CRC cis rs6674176 0.660 rs6680421 chr1:44408969 A/C cg13606994 chr1:44402422 ARTN 0.38 6.23 0.32 1.43e-9 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Cognitive ability; CRC cis rs11690935 0.959 rs3770451 chr2:172668715 T/G cg13550731 chr2:172543902 DYNC1I2 -1.08 -18.41 -0.71 1.62e-52 Schizophrenia; CRC cis rs897984 0.683 rs9932572 chr16:30841642 A/G cg00531865 chr16:30841666 NA -0.53 -8.04 -0.41 1.64e-14 Dementia with Lewy bodies; CRC cis rs1451375 0.794 rs11238134 chr7:50542927 A/C cg18232548 chr7:50535776 DDC -0.5 -7.72 -0.39 1.45e-13 Malaria; CRC cis rs7249142 0.549 rs7260127 chr19:19280499 C/T cg08207377 chr19:19281140 LOC729991-MEF2B;MEF2B 0.37 5.99 0.31 5.59e-9 IgG glycosylation; CRC cis rs1577917 0.958 rs13207354 chr6:86700263 A/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.52 -6.8 -0.35 5.06e-11 Response to antipsychotic treatment; CRC cis rs10504229 1.000 rs58947041 chr8:58188934 G/A cg02725872 chr8:58115012 NA -0.38 -6.43 -0.33 4.61e-10 Developmental language disorder (linguistic errors); CRC cis rs57590327 0.528 rs3821552 chr3:81702139 A/G cg07356753 chr3:81810745 GBE1 -0.65 -8.46 -0.42 8.63e-16 Extraversion; CRC cis rs9549328 0.700 rs2185001 chr13:113616369 G/T cg25790453 chr13:113633590 MCF2L -0.51 -8.79 -0.44 8.75e-17 Systolic blood pressure; CRC cis rs7258465 1.000 rs8109573 chr19:18617151 G/T cg01065977 chr19:18549689 ISYNA1 -0.41 -6.41 -0.33 5.18e-10 Breast cancer; CRC cis rs11098499 0.866 rs9991221 chr4:120292107 G/C cg09307838 chr4:120376055 NA 0.68 10.53 0.5 1.51e-22 Corneal astigmatism; CRC cis rs2204008 0.840 rs7957966 chr12:37953629 A/G cg13010199 chr12:38710504 ALG10B -0.5 -7.28 -0.37 2.47e-12 Bladder cancer; CRC cis rs9467773 0.620 rs2504566 chr6:26660488 G/C cg09904177 chr6:26538194 HMGN4 0.72 11.39 0.53 1.47e-25 Intelligence (multi-trait analysis); CRC trans rs11252926 0.565 rs60553947 chr10:474284 T/C cg00953403 chr17:74099816 EXOC7 -0.49 -7.38 -0.38 1.27e-12 Psychosis in Alzheimer's disease; CRC trans rs1005277 0.579 rs2505240 chr10:38442419 G/T cg11292332 chr7:45801988 SEPT13 -0.35 -6.22 -0.32 1.51e-9 Extrinsic epigenetic age acceleration; CRC cis rs1153858 1.000 rs7402650 chr15:45701895 C/T cg21132104 chr15:45694354 SPATA5L1 0.61 8.64 0.43 2.4e-16 Homoarginine levels; CRC cis rs10504229 1.000 rs73607875 chr8:58173522 T/C cg02725872 chr8:58115012 NA -0.38 -6.43 -0.33 4.44e-10 Developmental language disorder (linguistic errors); CRC cis rs172166 0.637 rs1225595 chr6:28151340 A/T cg12273811 chr6:28175739 NA 0.67 10.11 0.49 4.27e-21 Cardiac Troponin-T levels; CRC cis rs1451375 0.698 rs10899748 chr7:50646089 G/A cg14593290 chr7:50529359 DDC 0.56 7.27 0.37 2.7e-12 Malaria; CRC cis rs11690935 0.655 rs12997093 chr2:172564438 A/G cg13550731 chr2:172543902 DYNC1I2 0.65 9.62 0.47 1.79e-19 Schizophrenia; CRC cis rs13191362 1.000 rs13206253 chr6:163166902 A/G cg21926612 chr6:163149169 PACRG;PARK2 0.82 11.36 0.53 1.86e-25 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs600806 0.850 rs1880670 chr1:109941133 C/T cg23032129 chr1:109941072 SORT1 -0.28 -6.06 -0.32 3.68e-9 Intelligence (multi-trait analysis); CRC cis rs644799 0.965 rs566877 chr11:95528045 G/A cg25622487 chr11:95524042 FAM76B;CEP57 0.76 11.87 0.55 2.62e-27 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC trans rs12599106 0.839 rs3853177 chr16:34498532 A/G cg26668828 chr6:292823 DUSP22 -0.59 -8.61 -0.43 3.05e-16 Menopause (age at onset); CRC trans rs7267979 0.932 rs417130 chr20:25458320 T/C cg17903999 chr18:56338584 MALT1 -0.4 -6.8 -0.35 4.96e-11 Liver enzyme levels (alkaline phosphatase); CRC cis rs17767392 0.813 rs12887261 chr14:71941979 A/T cg13720639 chr14:72061746 SIPA1L1 -0.49 -6.34 -0.33 7.52e-10 Mitral valve prolapse; CRC cis rs6502050 0.835 rs35555954 chr17:80122438 T/C cg13198984 chr17:80129470 CCDC57 0.48 8.52 0.43 5.83e-16 Life satisfaction; CRC cis rs6951245 0.744 rs10265758 chr7:1172518 C/T cg04025307 chr7:1156635 C7orf50 0.67 7.92 0.4 3.57e-14 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs9303401 0.659 rs8074016 chr17:56840587 A/G cg10487724 chr17:56770010 TEX14;RAD51C 0.73 8.92 0.44 3.42e-17 Cognitive test performance; CRC cis rs10193935 0.901 rs62142639 chr2:42600019 C/G cg27598129 chr2:42591480 NA -0.68 -7.7 -0.39 1.56e-13 Colonoscopy-negative controls vs population controls; CRC cis rs6951245 1.000 rs2363286 chr7:1091625 A/G cg26224354 chr7:1096374 C7orf50;GPR146 -0.9 -11.98 -0.55 1.07e-27 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC trans rs1656966 1.000 rs1656966 chr3:186466252 C/T cg11065834 chr7:131012360 MKLN1 0.38 6.03 0.32 4.51e-9 Myopia (pathological); CRC cis rs35110281 0.667 rs4819287 chr21:45120147 A/G cg21573476 chr21:45109991 RRP1B -0.4 -5.95 -0.31 7.01e-9 Mean corpuscular volume; CRC cis rs853679 0.517 rs9348794 chr6:28117757 T/A cg15845792 chr6:28175446 NA 1.04 13.89 0.61 7.67e-35 Depression; CRC cis rs9611565 0.694 rs2142505 chr22:41820541 A/G cg03806693 chr22:41940476 POLR3H 1.1 13.39 0.59 6.08e-33 Vitiligo; CRC cis rs1707322 0.964 rs6675259 chr1:46502295 G/A cg06784218 chr1:46089804 CCDC17 -0.58 -10.25 -0.49 1.35e-21 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg03241323 chr2:187454863 ITGAV 0.4 6.63 0.34 1.38e-10 Liver disease severity in Alagille syndrome; CRC cis rs7517126 1.000 rs7412359 chr1:196832925 G/A cg13682187 chr1:196946512 CFHR5 -0.4 -6.35 -0.33 7.26e-10 Blood protein levels; CRC cis rs798554 0.686 rs7777484 chr7:2814271 A/G cg19717773 chr7:2847554 GNA12 -0.46 -7.4 -0.38 1.14e-12 Height; CRC cis rs10992471 0.580 rs10122383 chr9:95554675 A/G cg14631576 chr9:95140430 CENPP -0.34 -5.66 -0.3 3.38e-8 Visceral adipose tissue/subcutaneous adipose tissue ratio; CRC cis rs6570726 0.935 rs906774 chr6:145813770 T/C cg05347473 chr6:146136440 FBXO30 0.37 5.93 0.31 7.63e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs4743820 0.651 rs4237213 chr9:93932708 A/T cg14446406 chr9:93919335 NA -0.75 -13.49 -0.6 2.61e-33 Ulcerative colitis;Inflammatory bowel disease; CRC cis rs9916302 0.904 rs1966916 chr17:37425238 T/G cg03013999 chr17:37608204 MED1 0.48 7.43 0.38 9.6e-13 Glomerular filtration rate (creatinine); CRC cis rs2153535 0.580 rs6597337 chr6:8531652 C/T cg07606381 chr6:8435919 SLC35B3 0.67 10.99 0.52 3.99e-24 Motion sickness; CRC cis rs2842992 0.724 rs1128670 chr6:160211636 G/A cg16489826 chr6:160211363 TCP1;MRPL18 0.61 8.99 0.44 1.94e-17 Age-related macular degeneration (geographic atrophy); CRC cis rs6570726 0.791 rs9373463 chr6:145894762 C/T cg23711669 chr6:146136114 FBXO30 0.69 11.52 0.54 4.94e-26 Lobe attachment (rater-scored or self-reported); CRC cis rs9905704 0.918 rs302880 chr17:56761411 C/T cg12560992 chr17:57184187 TRIM37 0.56 7.72 0.39 1.41e-13 Testicular germ cell tumor; CRC cis rs6764363 0.616 rs9813769 chr3:286023 C/T cg02057681 chr3:285234 CHL1 0.38 5.8 0.3 1.54e-8 Sudden cardiac arrest; CRC cis rs34375054 0.738 rs10773145 chr12:125625603 C/T cg06987292 chr12:125626746 AACS 0.34 5.96 0.31 6.54e-9 Post bronchodilator FEV1/FVC ratio; CRC cis rs17376456 0.877 rs10055741 chr5:93297187 C/T cg09848695 chr5:92956644 FAM172A;MIR2277 0.63 5.67 0.3 3.18e-8 Diabetic retinopathy; CRC cis rs17253792 0.822 rs79747476 chr14:56160485 C/A cg01858014 chr14:56050164 KTN1 -0.89 -7.11 -0.37 7.14e-12 Putamen volume; CRC cis rs6860806 0.661 rs1588263 chr5:131577158 T/C cg18301423 chr5:131593218 PDLIM4 0.37 7.0 0.36 1.46e-11 Breast cancer; CRC cis rs7833790 0.927 rs61020899 chr8:82757090 C/T cg27398817 chr8:82754497 SNX16 0.55 6.66 0.34 1.12e-10 Diastolic blood pressure; CRC cis rs6088590 0.648 rs6058105 chr20:33271719 C/T cg24642439 chr20:33292090 TP53INP2 0.46 8.07 0.41 1.31e-14 Coronary artery disease; CRC trans rs916888 0.773 rs199445 chr17:44817408 C/T cg10053473 chr17:62856997 LRRC37A3 -0.78 -8.8 -0.44 8.02e-17 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs9527 0.571 rs12765337 chr10:104635344 G/C cg08772003 chr10:104629869 AS3MT -0.35 -5.8 -0.3 1.53e-8 Arsenic metabolism; CRC cis rs116161686 0.500 rs76610459 chr1:210050756 T/G cg22029157 chr1:209979665 IRF6 0.59 6.94 0.36 2.1e-11 Coronary artery disease; CRC cis rs4332037 0.826 rs4721188 chr7:1953615 G/A cg25834613 chr7:1915315 MAD1L1 0.4 5.9 0.31 8.83e-9 Bipolar disorder; CRC cis rs9916302 0.706 rs9899069 chr17:37540772 A/G cg07936489 chr17:37558343 FBXL20 0.92 11.73 0.54 9.09e-27 Glomerular filtration rate (creatinine); CRC trans rs2243480 1.000 rs78803505 chr7:65382572 A/T cg10756647 chr7:56101905 PSPH 0.73 8.07 0.41 1.36e-14 Diabetic kidney disease; CRC cis rs972578 0.967 rs926353 chr22:43371507 T/A cg01576275 chr22:43409880 NA -0.46 -7.36 -0.38 1.52e-12 Mean platelet volume; CRC cis rs67340775 0.541 rs200974 chr6:27855845 A/G cg06470822 chr6:28175283 NA 0.82 8.34 0.42 2.13e-15 Lung cancer in ever smokers; CRC cis rs73198271 0.531 rs17630714 chr8:8657681 C/T cg01851573 chr8:8652454 MFHAS1 0.52 6.25 0.33 1.27e-9 Bone ultrasound measurement (broadband ultrasound attenuation); CRC cis rs4713118 0.869 rs9295743 chr6:27715102 G/C cg12172441 chr6:28176163 NA 0.53 7.28 0.37 2.5e-12 Parkinson's disease; CRC trans rs875971 0.660 rs2191268 chr7:66110224 C/T cg14263244 chr12:80329611 PPP1R12A -0.4 -6.29 -0.33 9.95e-10 Aortic root size; CRC cis rs9292777 0.901 rs6876242 chr5:40422938 A/C cg09067459 chr5:40385259 NA 0.53 9.25 0.45 3.02e-18 Crohn's disease;Multiple sclerosis; CRC cis rs2836974 0.666 rs1888487 chr21:40683259 A/G cg11644478 chr21:40555479 PSMG1 -0.69 -11.0 -0.52 3.48e-24 Cognitive function; CRC cis rs2408955 0.522 rs2051851 chr12:48485940 G/C cg21466736 chr12:48725269 NA 0.46 7.12 0.37 6.99e-12 Glycated hemoglobin levels; CRC cis rs6951245 1.000 rs78185801 chr7:1096367 G/A cg26224354 chr7:1096374 C7orf50;GPR146 -0.93 -12.11 -0.56 3.59e-28 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC trans rs10242455 0.702 rs45448997 chr7:99041598 G/C cg09045935 chr12:6379348 NA 1.13 9.23 0.45 3.42e-18 Blood metabolite levels; CRC cis rs1044826 0.692 rs169824 chr3:139235006 G/C cg00490450 chr3:139108681 COPB2 -0.43 -6.49 -0.34 3.11e-10 Obesity-related traits; CRC cis rs2991971 1.000 rs667626 chr1:46020551 T/C cg15605315 chr1:45957053 TESK2 0.42 6.59 0.34 1.75e-10 High light scatter reticulocyte count; CRC cis rs1448094 0.512 rs12314318 chr12:86249238 T/C cg00310523 chr12:86230176 RASSF9 0.35 5.93 0.31 7.63e-9 Major depressive disorder; CRC cis rs6089584 0.526 rs6089316 chr20:60627552 C/T cg23262073 chr20:60523788 NA -0.42 -6.63 -0.34 1.38e-10 Body mass index; CRC cis rs951366 0.903 rs708723 chr1:205739266 C/T cg14159672 chr1:205819179 PM20D1 0.43 6.24 0.33 1.33e-9 Menarche (age at onset); CRC cis rs2933343 0.700 rs789240 chr3:128630635 T/C cg11901034 chr3:128598214 ACAD9 -0.56 -8.15 -0.41 7.75e-15 IgG glycosylation; CRC cis rs514406 0.798 rs575138 chr1:53328394 C/G cg25767906 chr1:53392781 SCP2 -0.51 -8.26 -0.41 3.59e-15 Monocyte count; CRC cis rs8062405 1.000 rs56404918 chr16:28846840 T/G cg08761264 chr16:28874980 SH2B1 -0.42 -5.64 -0.3 3.73e-8 Cognitive ability (multi-trait analysis);Cognitive ability; CRC cis rs13118159 0.742 rs7679860 chr4:1333987 C/T cg23123621 chr4:1343375 KIAA1530 0.37 6.38 0.33 6.03e-10 Longevity; CRC cis rs4713118 0.513 rs149958 chr6:28013617 A/C cg20615401 chr6:28092323 ZSCAN16 0.46 6.14 0.32 2.33e-9 Parkinson's disease; CRC trans rs4276421 0.806 rs6892594 chr5:45427173 C/T cg04793272 chr11:119020941 ABCG4 -0.37 -6.15 -0.32 2.28e-9 P wave duration; CRC cis rs7666738 0.927 rs4699328 chr4:99055890 C/T cg05340658 chr4:99064831 C4orf37 0.6 9.47 0.46 5.66e-19 Colonoscopy-negative controls vs population controls; CRC cis rs561341 1.000 rs1557731 chr17:30321567 T/G cg19193384 chr17:30244184 NA -0.54 -6.91 -0.36 2.52e-11 Hip circumference adjusted for BMI; CRC cis rs8180040 0.966 rs6800271 chr3:47470787 A/T cg27129171 chr3:47204927 SETD2 -0.61 -9.69 -0.47 1.11e-19 Colorectal cancer; CRC cis rs704795 0.836 rs1647281 chr2:27612938 G/C cg24768116 chr2:27665128 KRTCAP3 -0.35 -7.85 -0.4 6.05e-14 Menopause (age at onset); CRC cis rs651907 0.535 rs2290859 chr3:101525625 C/T cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.58 7.73 0.39 1.33e-13 Colorectal cancer; CRC cis rs7412746 0.658 rs6677420 chr1:150946490 G/A cg17724175 chr1:150552817 MCL1 0.47 6.88 0.35 3.11e-11 Melanoma; CRC cis rs9311474 0.607 rs13076398 chr3:52573096 G/A cg10802521 chr3:52805072 NEK4 -0.53 -8.28 -0.42 3.18e-15 Electroencephalogram traits; CRC cis rs7904368 0.568 rs7075036 chr10:16864810 C/T cg23933602 chr10:16859644 RSU1 0.76 12.26 0.56 1.01e-28 Ratio of the peak velocity of the mitral E-Wave divided by the peak velocity of the mitral A-wave.; CRC cis rs11758351 0.789 rs2069020 chr6:26205500 C/T cg22723502 chr6:26240528 HIST1H4F -0.39 -6.31 -0.33 8.78e-10 Gout;Renal underexcretion gout; CRC cis rs7937840 0.559 rs2000957 chr11:61877744 A/G cg01969543 chr11:61895209 INCENP -0.52 -7.35 -0.38 1.57e-12 Breast cancer; CRC cis rs11212617 0.935 rs186591 chr11:108200142 T/G cg12106634 chr11:108092400 ATM;NPAT 0.41 6.0 0.31 5.15e-9 Response to metformin in type 2 diabetes (glycemic); CRC cis rs1832871 0.521 rs62437410 chr6:158822888 G/C cg07165851 chr6:158734300 TULP4 0.45 5.89 0.31 9.7e-9 Height; CRC cis rs9916302 0.904 rs801419 chr17:37466327 A/G cg15445000 chr17:37608096 MED1 -0.4 -8.5 -0.42 6.75e-16 Glomerular filtration rate (creatinine); CRC cis rs6815814 0.861 rs73142654 chr4:38785697 T/A cg06935464 chr4:38784597 TLR10 0.69 9.03 0.45 1.49e-17 Breast cancer; CRC cis rs12681287 0.547 rs9297922 chr8:87542317 A/G cg27223183 chr8:87520930 FAM82B 0.5 6.72 0.35 7.91e-11 Caudate activity during reward; CRC cis rs1401999 1.000 rs4148579 chr3:183685249 T/C cg20387954 chr3:183756860 HTR3D 0.45 7.62 0.39 2.65e-13 Anterior chamber depth; CRC cis rs910316 0.737 rs175055 chr14:75488946 T/G cg03030879 chr14:75389066 RPS6KL1 0.42 6.46 0.34 3.75e-10 Height; CRC cis rs6543140 0.964 rs6543138 chr2:103066132 G/A cg09003973 chr2:102972529 NA 0.4 5.76 0.3 1.91e-8 Blood protein levels; CRC cis rs1552244 0.882 rs61429272 chr3:10037320 G/C cg08888203 chr3:10149979 C3orf24 0.62 8.3 0.42 2.65e-15 Alzheimer's disease; CRC trans rs10982213 0.830 rs2274163 chr9:117188714 C/T cg25314532 chr22:38349562 C22orf23;POLR2F 0.39 6.03 0.32 4.44e-9 Interleukin-6 levels; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg07235652 chr12:109531354 ALKBH2 0.38 6.15 0.32 2.21e-9 Liver disease severity in Alagille syndrome; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg17384870 chr19:52772871 ZNF766 0.42 6.47 0.34 3.61e-10 Intelligence (multi-trait analysis); CRC cis rs2050392 0.624 rs303435 chr10:30731491 T/C cg25182066 chr10:30743637 MAP3K8 -0.45 -6.03 -0.32 4.34e-9 Inflammatory bowel disease; CRC trans rs11098499 0.775 rs10029303 chr4:120286755 T/A cg25214090 chr10:38739885 LOC399744 0.61 9.66 0.47 1.39e-19 Corneal astigmatism; CRC cis rs9733 0.596 rs11204697 chr1:150658971 C/T cg18016565 chr1:150552671 MCL1 0.46 6.74 0.35 6.91e-11 Tonsillectomy; CRC cis rs1524976 1.000 rs2177685 chr3:65491171 T/C cg16238336 chr3:65465873 MAGI1 -0.53 -6.79 -0.35 5.34e-11 PR interval; CRC cis rs875971 0.545 rs10950027 chr7:65634151 C/T cg03233332 chr7:66118400 NA -0.45 -6.35 -0.33 7.35e-10 Aortic root size; CRC cis rs947211 0.846 rs708726 chr1:205762139 G/T cg14893161 chr1:205819251 PM20D1 -0.45 -6.65 -0.34 1.24e-10 Parkinson's disease; CRC cis rs1580019 0.563 rs764483 chr7:32578150 A/T cg06627557 chr7:32535165 LSM5;AVL9 0.96 18.22 0.71 9.09e-52 Cognitive ability; CRC cis rs6570726 0.791 rs9376945 chr6:145828080 T/A cg23711669 chr6:146136114 FBXO30 0.74 12.97 0.58 2.27e-31 Lobe attachment (rater-scored or self-reported); CRC cis rs10206020 0.885 rs11885392 chr2:1578182 C/A cg12573674 chr2:1569213 NA -0.77 -10.15 -0.49 3.03e-21 IgG glycosylation; CRC cis rs6502050 0.835 rs34960918 chr17:80113925 A/G cg09264619 chr17:80180166 NA -0.34 -5.81 -0.3 1.5e-8 Life satisfaction; CRC cis rs28386778 0.897 rs2584635 chr17:61865934 A/G cg06601766 chr17:61851465 DDX42;CCDC47 0.46 6.2 0.32 1.66e-9 Prudent dietary pattern; CRC cis rs7091068 0.671 rs1223296 chr10:95404621 T/C cg20715218 chr10:95462985 C10orf4 -0.48 -5.66 -0.3 3.38e-8 Urinary tract infection frequency; CRC cis rs10540 1.000 rs35996687 chr11:458595 G/A cg03934478 chr11:495069 RNH1 0.69 7.13 0.37 6.34e-12 Body mass index; CRC cis rs6479527 0.875 rs1331216 chr9:96767722 G/A cg14459158 chr9:96720562 NA 0.37 6.79 0.35 5.09e-11 Esophageal adenocarcinoma; CRC trans rs11098499 0.955 rs35916640 chr4:120155852 T/C cg25214090 chr10:38739885 LOC399744 0.51 7.84 0.4 6.42e-14 Corneal astigmatism; CRC cis rs17376456 0.825 rs72786702 chr5:93254656 A/C cg25358565 chr5:93447407 FAM172A 1.11 10.98 0.52 4.31e-24 Diabetic retinopathy; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg08872713 chr16:56716227 MT1X 0.46 5.98 0.31 5.72e-9 Anxiety disorder; CRC cis rs3733585 0.673 rs10000983 chr4:9951606 T/C cg11266682 chr4:10021025 SLC2A9 -0.48 -9.83 -0.48 3.62e-20 Cleft plate (environmental tobacco smoke interaction); CRC cis rs9488822 0.676 rs868943 chr6:116337503 G/A cg15226275 chr6:116381976 FRK 0.3 8.56 0.43 4.5e-16 Cholesterol, total;LDL cholesterol; CRC cis rs10883723 0.810 rs7090034 chr10:104281155 C/G cg04362960 chr10:104952993 NT5C2 -0.42 -5.9 -0.31 8.92e-9 Allergic disease (asthma, hay fever or eczema); CRC cis rs11785400 1.000 rs3824208 chr8:143743653 C/G cg24634471 chr8:143751801 JRK 0.53 7.55 0.38 4.46e-13 Schizophrenia; CRC cis rs35520189 0.591 rs12466697 chr2:113709876 C/G cg12858261 chr2:113808755 IL1F8 0.46 6.07 0.32 3.53e-9 Obstructive sleep apnea trait (apnea hypopnea index); CRC cis rs908922 0.676 rs11205031 chr1:152527662 C/T cg09873164 chr1:152488093 CRCT1 0.4 6.74 0.35 7.22e-11 Hair morphology; CRC cis rs17818399 0.620 rs1080871 chr2:46854708 A/G cg26688816 chr2:46740690 ATP6V1E2 -0.41 -6.09 -0.32 3.09e-9 Height; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg16055035 chr6:13487883 GFOD1;C6orf114 0.41 6.25 0.33 1.27e-9 Intelligence (multi-trait analysis); CRC cis rs1223397 0.651 rs2439534 chr6:13305757 C/T cg20827128 chr6:13274284 PHACTR1 -0.4 -6.03 -0.32 4.29e-9 Blood pressure; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg18845289 chr12:121124611 MLEC 0.44 6.31 0.33 9.18e-10 Response to antipsychotic treatment; CRC cis rs7208859 0.725 rs9891656 chr17:29243355 A/T cg14008862 chr17:28927542 LRRC37B2 0.47 5.87 0.31 1.04e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs17095355 0.901 rs12240333 chr10:111743972 T/A cg00817464 chr10:111662876 XPNPEP1 -0.63 -8.57 -0.43 3.99e-16 Biliary atresia; CRC cis rs2050392 1.000 rs7077496 chr10:30692028 G/A cg18806716 chr10:30721971 MAP3K8 0.45 6.82 0.35 4.44e-11 Inflammatory bowel disease; CRC cis rs12464483 0.591 rs4952170 chr2:30885429 G/A cg17749961 chr2:30669863 LCLAT1 0.54 5.7 0.3 2.64e-8 Pre-treatment pain in head and neck squamous cell carcinoma; CRC cis rs796364 1.000 rs281763 chr2:200794870 C/T cg25936922 chr2:200820526 C2orf60;C2orf47 0.7 7.65 0.39 2.21e-13 Schizophrenia; CRC cis rs2197308 0.659 rs11181327 chr12:37903171 C/T cg13010199 chr12:38710504 ALG10B -0.49 -7.17 -0.37 4.87e-12 Morning vs. evening chronotype; CRC cis rs1862618 0.853 rs252922 chr5:56136343 G/T cg18230493 chr5:56204884 C5orf35 -0.7 -9.07 -0.45 1.13e-17 Initial pursuit acceleration; CRC trans rs11098499 0.874 rs12509054 chr4:120115075 A/C cg25214090 chr10:38739885 LOC399744 0.52 7.73 0.39 1.34e-13 Corneal astigmatism; CRC cis rs7091068 0.671 rs1764322 chr10:95406276 T/G cg20715218 chr10:95462985 C10orf4 -0.46 -5.61 -0.3 4.29e-8 Urinary tract infection frequency; CRC cis rs7224685 0.520 rs12453690 chr17:4037678 T/C cg09695851 chr17:3907499 NA -0.75 -13.13 -0.59 5.82e-32 Type 2 diabetes; CRC cis rs8060686 0.641 rs113162813 chr16:68038969 A/G cg27539214 chr16:67997921 SLC12A4 -0.46 -5.64 -0.3 3.71e-8 HDL cholesterol;Metabolic syndrome; CRC cis rs853679 0.517 rs9380052 chr6:28064623 A/G cg21251018 chr6:28226885 NKAPL 0.5 6.49 0.34 3.1e-10 Depression; CRC cis rs896854 0.654 rs16893776 chr8:95973604 C/T cg16049864 chr8:95962084 TP53INP1 -0.64 -11.72 -0.54 9.25e-27 Type 2 diabetes; CRC trans rs1005277 0.579 rs2474571 chr10:38384639 T/G cg27523141 chr10:43048294 ZNF37B 0.5 7.24 0.37 3.2e-12 Extrinsic epigenetic age acceleration; CRC cis rs7527798 0.592 rs960088 chr1:207827067 A/C cg21110645 chr1:207815933 NA -0.39 -6.18 -0.32 1.9e-9 Erythrocyte sedimentation rate; CRC cis rs317689 0.690 rs547827 chr12:69669703 G/A cg14784868 chr12:69753453 YEATS4 0.44 5.66 0.3 3.28e-8 Response to diuretic therapy; CRC cis rs11758351 1.000 rs80095925 chr6:26184942 C/T cg10723962 chr6:26240782 HIST1H4F -0.41 -6.0 -0.31 5.21e-9 Gout;Renal underexcretion gout; CRC cis rs853679 0.546 rs200490 chr6:27796935 G/T cg23259851 chr6:27775964 HIST1H2AI;HIST1H2BL 0.67 5.69 0.3 2.85e-8 Depression; CRC cis rs4478858 0.735 rs4622114 chr1:31772571 A/G cg00250761 chr1:31883323 NA -0.43 -8.36 -0.42 1.84e-15 Alcohol dependence; CRC cis rs9467711 0.606 rs13190739 chr6:26587373 G/T cg16898833 chr6:26189333 HIST1H4D 1.14 8.46 0.42 8.89e-16 Autism spectrum disorder or schizophrenia; CRC cis rs3733585 0.588 rs6449154 chr4:9956404 C/T cg00071950 chr4:10020882 SLC2A9 -0.55 -9.75 -0.47 6.56e-20 Cleft plate (environmental tobacco smoke interaction); CRC cis rs9311474 0.659 rs1133415 chr3:52575831 G/A cg18591801 chr3:52553433 STAB1 -0.31 -5.89 -0.31 9.67e-9 Electroencephalogram traits; CRC cis rs728616 0.681 rs12769764 chr10:81917113 C/G cg14775751 chr10:81965438 ANXA11 -0.43 -5.7 -0.3 2.63e-8 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs2806561 0.929 rs2746556 chr1:23524541 G/A cg19743168 chr1:23544995 NA 0.4 6.21 0.32 1.58e-9 Height; CRC cis rs4237845 0.591 rs10747788 chr12:58315338 C/T cg00677455 chr12:58241039 CTDSP2 0.49 6.47 0.34 3.59e-10 Intelligence (multi-trait analysis); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg02836830 chr20:3767452 CENPB 0.42 6.92 0.36 2.35e-11 Liver disease severity in Alagille syndrome; CRC cis rs7246657 0.943 rs10424574 chr19:37838393 A/G cg23950597 chr19:37808831 NA -0.54 -6.5 -0.34 2.93e-10 Coronary artery calcification; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg27194998 chr19:47217554 PRKD2 -0.4 -6.22 -0.32 1.47e-9 Myopia (pathological); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg13045639 chr21:40555880 PSMG1 0.37 6.12 0.32 2.72e-9 Liver disease severity in Alagille syndrome; CRC trans rs1814175 0.817 rs12287396 chr11:49819798 G/C cg11707556 chr5:10655725 ANKRD33B -0.42 -7.91 -0.4 4.04e-14 Height; CRC cis rs12999616 0.817 rs35321033 chr2:98327812 T/C cg26665480 chr2:98280029 ACTR1B 0.52 6.43 0.33 4.6e-10 Colorectal cancer; CRC cis rs10751667 0.961 rs6421967 chr11:983966 T/C ch.11.42038R chr11:967971 AP2A2 0.67 11.08 0.52 1.8e-24 Alzheimer's disease (late onset); CRC cis rs7552404 0.960 rs12085123 chr1:76149749 G/A cg22875332 chr1:76189707 ACADM 0.68 9.29 0.46 2.24e-18 Blood metabolite levels;Acylcarnitine levels; CRC cis rs28374715 0.578 rs8036026 chr15:41630499 C/G cg18705301 chr15:41695430 NDUFAF1 -1.09 -18.75 -0.72 6.99e-54 Ulcerative colitis; CRC cis rs4713118 0.869 rs7776351 chr6:27726731 A/G cg12172441 chr6:28176163 NA -0.52 -7.19 -0.37 4.41e-12 Parkinson's disease; CRC cis rs3785574 1.000 rs3785574 chr17:61763185 T/C cg06601766 chr17:61851465 DDX42;CCDC47 0.6 8.29 0.42 2.83e-15 Height; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg03582286 chr4:71571171 RUFY3 0.43 6.58 0.34 1.89e-10 Intelligence (multi-trait analysis); CRC cis rs2462686 0.798 rs13241830 chr7:45961058 G/A cg23193639 chr7:45961078 IGFBP3 -0.37 -5.72 -0.3 2.37e-8 Major depressive disorder; CRC cis rs6951245 0.745 rs79788515 chr7:1101079 C/T cg04025307 chr7:1156635 C7orf50 0.63 6.69 0.35 9.69e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs769267 0.930 rs4808967 chr19:19640524 A/G cg02546618 chr19:19431379 KIAA0892;SF4 0.42 5.65 0.3 3.41e-8 Tonsillectomy; CRC trans rs11098499 0.754 rs1980026 chr4:120251643 C/A cg25214090 chr10:38739885 LOC399744 0.53 8.36 0.42 1.81e-15 Corneal astigmatism; CRC cis rs1552244 1.000 rs35198334 chr3:10104553 G/C cg16606324 chr3:10149918 C3orf24 0.71 9.38 0.46 1.1e-18 Alzheimer's disease; CRC cis rs4713118 0.621 rs9295756 chr6:28033396 G/T cg06470822 chr6:28175283 NA 0.96 13.02 0.58 1.54e-31 Parkinson's disease; CRC cis rs12681288 0.862 rs935821 chr8:1022455 G/A cg08648136 chr8:956695 NA 0.31 5.8 0.3 1.57e-8 Schizophrenia; CRC trans rs7580658 0.614 rs7585198 chr2:127962635 C/T cg06384055 chr11:17099234 RPS13 -0.49 -6.76 -0.35 6.22e-11 Protein C levels; CRC cis rs9611565 0.838 rs4239894 chr22:41745548 C/G cg03806693 chr22:41940476 POLR3H -0.92 -12.1 -0.55 3.99e-28 Vitiligo; CRC cis rs752092 0.802 rs2412005 chr15:101767591 T/A cg19997662 chr15:101784653 CHSY1 -0.49 -7.58 -0.39 3.53e-13 Corneal structure; CRC cis rs826838 0.935 rs11183940 chr12:38851642 A/G cg26384229 chr12:38710491 ALG10B 0.75 10.59 0.5 9.64e-23 Heart rate; CRC cis rs270601 0.913 rs273916 chr5:131659830 C/A cg22638593 chr5:131593259 PDLIM4 0.38 6.24 0.33 1.34e-9 Acylcarnitine levels; CRC cis rs11711311 1.000 rs9863050 chr3:113508888 C/G cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.52 -7.04 -0.36 1.14e-11 IgG glycosylation; CRC cis rs9443645 0.810 rs9361482 chr6:79750385 T/C cg09184832 chr6:79620586 NA -0.5 -8.91 -0.44 3.62e-17 Intelligence (multi-trait analysis); CRC cis rs9487051 0.700 rs9400266 chr6:109596193 T/A cg12927641 chr6:109611667 NA -0.36 -6.44 -0.33 4.15e-10 Reticulocyte fraction of red cells; CRC cis rs35883536 0.967 rs4908090 chr1:101135177 A/G cg14515779 chr1:101123966 NA -0.39 -7.57 -0.39 3.7e-13 Monocyte count; CRC trans rs459571 0.916 rs109536 chr9:136889987 G/C cg15028160 chr19:49622717 PPFIA3;C19orf73 -0.55 -6.8 -0.35 5.03e-11 Platelet distribution width; CRC cis rs7705042 0.865 rs449454 chr5:141533062 A/G cg07392085 chr5:141489673 NDFIP1 0.46 7.33 0.37 1.83e-12 Asthma; CRC cis rs2730260 0.537 rs73169234 chr7:158882366 C/T cg02254261 chr7:158964346 NA -0.54 -6.19 -0.32 1.8e-9 Myopia (pathological); CRC cis rs4713118 0.527 rs9461433 chr6:28095172 C/T cg12273811 chr6:28175739 NA 0.73 9.36 0.46 1.34e-18 Parkinson's disease; CRC cis rs1046896 0.586 rs9897951 chr17:80810662 T/C cg19046167 chr17:80928561 B3GNTL1 0.53 7.46 0.38 7.68e-13 Glycated hemoglobin levels; CRC cis rs4014195 0.521 rs12576996 chr11:65580638 G/T cg27068330 chr11:65405492 SIPA1 0.55 6.88 0.35 2.99e-11 Glomerular filtration rate (creatinine);Chronic kidney disease; CRC cis rs977987 0.806 rs4887823 chr16:75433074 T/A cg03315344 chr16:75512273 CHST6 0.54 9.0 0.44 1.86e-17 Dupuytren's disease; CRC cis rs832540 0.629 rs10055224 chr5:56081201 C/T cg18230493 chr5:56204884 C5orf35 0.41 5.96 0.31 6.36e-9 Coronary artery disease; CRC trans rs35110281 0.712 rs167930 chr21:44946625 G/A cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.43 6.84 0.35 3.93e-11 Mean corpuscular volume; CRC cis rs17023223 0.537 rs1057990 chr1:119575232 T/C cg05756136 chr1:119680316 WARS2 -0.47 -6.38 -0.33 5.84e-10 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for BMI in active individuals; CRC cis rs9914988 0.943 rs11651867 chr17:27147248 T/G cg16670446 chr17:27188758 MIR451;MIR144 0.53 8.4 0.42 1.32e-15 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs2730245 0.527 rs842693 chr7:158660491 C/T cg24397884 chr7:158709396 WDR60 0.92 10.85 0.51 1.18e-23 Height; CRC cis rs7172677 1.000 rs4886658 chr15:75414536 A/C cg14664628 chr15:75095509 CSK -0.49 -5.75 -0.3 2.03e-8 Systemic lupus erythematosus and Systemic sclerosis; CRC cis rs2204008 0.837 rs11180482 chr12:38235950 G/A cg13010199 chr12:38710504 ALG10B 0.45 5.82 0.31 1.39e-8 Bladder cancer; CRC cis rs10871290 1.000 rs11149710 chr16:74472546 G/T cg01733217 chr16:74700730 RFWD3 -0.66 -10.5 -0.5 2.04e-22 Breast cancer; CRC cis rs4889855 0.530 rs4889872 chr17:78621306 G/A cg16591659 chr17:78472290 NA 0.41 5.81 0.31 1.44e-8 Fractional excretion of uric acid; CRC cis rs3736485 0.816 rs11070851 chr15:51763249 C/G cg08986416 chr15:51914746 DMXL2 0.47 6.87 0.35 3.19e-11 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC trans rs1005277 0.579 rs2474567 chr10:38382492 C/T cg17830980 chr10:43048298 ZNF37B -0.6 -9.97 -0.48 1.23e-20 Extrinsic epigenetic age acceleration; CRC cis rs6502050 0.761 rs62078754 chr17:80058666 C/T cg22110888 chr17:80059540 CCDC57 -0.44 -6.79 -0.35 5.31e-11 Life satisfaction; CRC cis rs6951245 0.938 rs112425403 chr7:1071531 A/G cg26224354 chr7:1096374 C7orf50;GPR146 -0.88 -11.02 -0.52 3.09e-24 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs16852403 0.548 rs28760457 chr1:178174485 G/C cg00404053 chr1:178313656 RASAL2 0.5 6.59 0.34 1.75e-10 Childhood ear infection; CRC cis rs2230307 0.536 rs482466 chr1:100488177 C/T cg24955406 chr1:100503596 HIAT1 0.52 6.15 0.32 2.21e-9 Carotid intima media thickness; CRC cis rs2204008 0.643 rs1315347 chr12:38162494 C/T cg13010199 chr12:38710504 ALG10B -0.43 -6.17 -0.32 1.96e-9 Bladder cancer; CRC cis rs6570726 0.967 rs1396648 chr6:145785248 C/A cg23711669 chr6:146136114 FBXO30 -0.62 -10.53 -0.5 1.57e-22 Lobe attachment (rater-scored or self-reported); CRC cis rs561341 1.000 rs554078 chr17:30330109 A/C cg12193833 chr17:30244370 NA -0.76 -8.89 -0.44 4.15e-17 Hip circumference adjusted for BMI; CRC cis rs1448094 0.511 rs61930579 chr12:86157044 G/A cg02569458 chr12:86230093 RASSF9 0.51 8.43 0.42 1.13e-15 Major depressive disorder; CRC cis rs2576037 0.583 rs512699 chr18:44374681 C/T cg07416455 chr18:44543612 TCEB3CL;KATNAL2 0.52 7.76 0.39 1.06e-13 Personality dimensions; CRC cis rs7927771 0.524 rs7932703 chr11:47769936 A/C cg20307385 chr11:47447363 PSMC3 0.46 6.59 0.34 1.73e-10 Subjective well-being; CRC cis rs11105298 0.786 rs3803128 chr12:89860319 C/A cg08166232 chr12:89918718 WDR51B;GALNT4 -0.61 -7.77 -0.39 1.01e-13 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; CRC cis rs9611519 0.929 rs9611474 chr22:41434858 G/A cg03806693 chr22:41940476 POLR3H -0.58 -7.33 -0.37 1.84e-12 Neuroticism; CRC cis rs10504229 0.679 rs17800895 chr8:58050085 A/G cg08219700 chr8:58056026 NA 0.56 6.65 0.34 1.2e-10 Developmental language disorder (linguistic errors); CRC cis rs1799949 1.000 rs11658754 chr17:41292739 G/A cg23758822 chr17:41437982 NA 0.79 13.45 0.6 3.6e-33 Menopause (age at onset); CRC cis rs3772130 0.962 rs13065245 chr3:121566729 C/A cg20356878 chr3:121714668 ILDR1 0.53 8.22 0.41 4.69e-15 Cognitive performance; CRC cis rs2952156 0.920 rs2517955 chr17:37843681 C/T cg00129232 chr17:37814104 STARD3 -0.74 -13.22 -0.59 2.63e-32 Asthma; CRC cis rs9470366 0.816 rs7742159 chr6:36619452 A/C cg08179530 chr6:36648295 CDKN1A 0.49 5.79 0.3 1.61e-8 QRS duration; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg19487718 chr4:185747708 ACSL1 0.47 6.21 0.32 1.63e-9 Thyroid stimulating hormone; CRC cis rs939584 1.000 rs7588007 chr2:631255 T/C cg03610516 chr2:642275 NA 0.43 5.61 0.3 4.36e-8 Body mass index; CRC cis rs2290405 0.527 rs6829987 chr4:932974 C/G cg04045327 chr4:905805 GAK 0.42 6.76 0.35 6.16e-11 Systemic sclerosis; CRC cis rs9354308 0.899 rs2802055 chr6:66545756 T/C cg07460842 chr6:66804631 NA 0.46 5.69 0.3 2.83e-8 Metabolite levels; CRC cis rs6723226 0.698 rs13409142 chr2:32666137 C/T cg02381751 chr2:32503542 YIPF4 0.61 8.78 0.44 9.13e-17 Intelligence (multi-trait analysis); CRC cis rs9467773 0.620 rs2504600 chr6:26648334 C/A cg09904177 chr6:26538194 HMGN4 0.72 11.39 0.53 1.47e-25 Intelligence (multi-trait analysis); CRC cis rs9296736 1.000 rs4715438 chr6:53901329 G/A cg04374786 chr6:53939321 C6orf142 -0.45 -7.3 -0.37 2.23e-12 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs6674176 0.628 rs4660759 chr1:44432500 C/G cg13606994 chr1:44402422 ARTN -0.34 -5.76 -0.3 1.94e-8 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Cognitive ability; CRC cis rs13361707 0.700 rs10055925 chr5:40688059 A/G cg09067459 chr5:40385259 NA -0.39 -5.62 -0.3 4.13e-8 Gastric cancer;Non-cardia gastric cancer; CRC cis rs6502050 0.871 rs9916649 chr17:80075739 G/A cg02741985 chr17:80059408 CCDC57 -0.45 -7.4 -0.38 1.17e-12 Life satisfaction; CRC cis rs7640424 0.620 rs17231503 chr3:107817299 C/T cg09227934 chr3:107805635 CD47 -0.49 -6.45 -0.34 3.93e-10 Body mass index; CRC cis rs875971 0.964 rs55748098 chr7:65763618 T/C cg12463550 chr7:65579703 CRCP -0.48 -6.9 -0.36 2.67e-11 Aortic root size; CRC cis rs9311474 0.597 rs13303 chr3:52558008 T/C cg08222913 chr3:52553049 STAB1 -0.41 -8.25 -0.41 3.88e-15 Electroencephalogram traits; CRC cis rs34779708 0.966 rs10508816 chr10:35459976 G/A cg03585969 chr10:35415529 CREM 0.56 7.6 0.39 3.13e-13 Inflammatory bowel disease;Crohn's disease; CRC cis rs34172651 0.917 rs8049667 chr16:24773524 G/A cg06505273 chr16:24850292 NA 0.38 5.62 0.3 4.13e-8 Intelligence (multi-trait analysis); CRC cis rs908922 0.676 rs12129646 chr1:152518816 C/T cg09873164 chr1:152488093 CRCT1 0.39 6.51 0.34 2.85e-10 Hair morphology; CRC cis rs7615952 0.599 rs60847438 chr3:125746005 T/C cg06494592 chr3:125709126 NA -0.55 -6.43 -0.33 4.43e-10 Blood pressure (smoking interaction); CRC cis rs7659604 0.643 rs6839054 chr4:122663628 C/T cg19748678 chr4:122722346 EXOSC9 0.47 6.72 0.35 7.96e-11 Type 2 diabetes; CRC trans rs877282 0.947 rs4133015 chr10:774131 T/C cg22713356 chr15:30763199 NA 1.11 14.42 0.62 7.42e-37 Uric acid levels; CRC cis rs7772486 0.701 rs697056 chr6:146003897 C/T cg05347473 chr6:146136440 FBXO30 -0.38 -5.69 -0.3 2.82e-8 Lobe attachment (rater-scored or self-reported); CRC cis rs11711311 0.866 rs13313893 chr3:113400856 A/G cg15478005 chr3:113465772 ATP6V1A;NAA50 0.44 5.9 0.31 9.12e-9 IgG glycosylation; CRC cis rs763121 0.813 rs4821807 chr22:39065582 A/G cg06022373 chr22:39101656 GTPBP1 0.79 12.6 0.57 5.45e-30 Menopause (age at onset); CRC cis rs8044868 0.512 rs10048144 chr16:72052891 C/G cg23815491 chr16:72088622 HP 0.47 6.66 0.34 1.14e-10 Body mass index (change over time) in cancer or chronic obstructive pulmonary disease;Body mass index (change over time) in cancer; CRC cis rs7666738 0.753 rs7659724 chr4:98944063 C/T cg05340658 chr4:99064831 C4orf37 0.6 9.4 0.46 9.52e-19 Colonoscopy-negative controls vs population controls; CRC cis rs7617480 0.558 rs12715430 chr3:48942855 A/C cg07636037 chr3:49044803 WDR6 0.86 10.69 0.51 4.24e-23 Subjective well-being (multi-trait analysis);Menarche (age at onset); CRC trans rs6833159 0.527 rs10939231 chr4:28829372 A/T cg07318372 chr1:240071102 CHRM3 0.45 6.26 0.33 1.19e-9 Underweight status; CRC cis rs10504229 0.679 rs16921606 chr8:58034477 A/C cg02725872 chr8:58115012 NA -0.34 -5.91 -0.31 8.68e-9 Developmental language disorder (linguistic errors); CRC cis rs6500602 0.727 rs7193136 chr16:4580034 C/T cg14951292 chr16:4525986 HMOX2;NMRAL1 0.56 8.32 0.42 2.32e-15 Schizophrenia; CRC cis rs4713118 0.516 rs7739216 chr6:28079946 G/T cg02683197 chr6:28174875 NA 0.84 10.18 0.49 2.42e-21 Parkinson's disease; CRC cis rs9311474 0.508 rs2878628 chr3:52584715 C/T cg05573699 chr3:52720067 GNL3;PBRM1 0.46 6.64 0.34 1.3e-10 Electroencephalogram traits; CRC cis rs651907 0.557 rs13081846 chr3:101383321 T/C cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.62 8.41 0.42 1.3e-15 Colorectal cancer; CRC cis rs3736594 0.513 rs78170284 chr2:27835082 G/A cg27432699 chr2:27873401 GPN1 0.67 8.18 0.41 6.42e-15 Fasting blood glucose;Fasting blood glucose (BMI interaction); CRC cis rs7811142 1.000 rs6962151 chr7:100028484 T/C cg00814883 chr7:100076585 TSC22D4 -0.72 -9.44 -0.46 7.01e-19 Platelet count; CRC cis rs981844 0.740 rs1020702 chr4:154685712 A/C cg10279832 chr4:154682576 RNF175 0.38 5.81 0.31 1.47e-8 Response to statins (LDL cholesterol change); CRC cis rs11229555 0.609 rs34133416 chr11:58184720 T/C cg15696309 chr11:58395628 NA -0.81 -10.31 -0.49 8.83e-22 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; CRC cis rs6120849 0.754 rs6120790 chr20:33599090 A/T cg24642439 chr20:33292090 TP53INP2 0.44 5.72 0.3 2.39e-8 Protein C levels; CRC cis rs6495122 0.662 rs12898997 chr15:75090349 C/T cg14664628 chr15:75095509 CSK -0.72 -11.9 -0.55 2.15e-27 Caffeine consumption;Diastolic blood pressure;Coffee consumption; CRC cis rs9992667 0.955 rs12331049 chr4:38655772 C/T cg19726192 chr4:38663646 FLJ13197 -0.72 -9.08 -0.45 1.02e-17 Eosinophil percentage of granulocytes; CRC cis rs3741404 0.609 rs641378 chr11:63869493 T/C cg19465662 chr11:63993652 NUDT22;TRPT1 0.6 9.33 0.46 1.59e-18 Platelet count; CRC cis rs6582630 0.548 rs1607870 chr12:38385964 G/T cg13010199 chr12:38710504 ALG10B -0.4 -5.71 -0.3 2.52e-8 Drug-induced liver injury (flucloxacillin); CRC cis rs4664293 0.567 rs6711125 chr2:160501551 C/T cg08347373 chr2:160653686 CD302 0.39 6.68 0.35 1.03e-10 Monocyte percentage of white cells; CRC cis rs10743315 0.643 rs58663385 chr12:19337070 T/C cg02471346 chr12:19282374 PLEKHA5 0.67 6.2 0.32 1.68e-9 Gut microbiota (bacterial taxa); CRC trans rs2303319 0.504 rs62188990 chr2:162540635 G/A cg27113153 chr11:123612418 ZNF202 -0.7 -6.14 -0.32 2.35e-9 Cognitive function; CRC cis rs754466 0.651 rs11002322 chr10:79649653 G/T cg26805224 chr10:79626177 DLG5 -0.54 -7.98 -0.4 2.5e-14 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs73206853 0.841 rs3026483 chr12:110780905 A/G cg12870014 chr12:110450643 ANKRD13A 0.76 8.25 0.41 3.78e-15 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC cis rs4711336 0.664 rs4713662 chr6:33674188 A/G cg14003231 chr6:33640908 ITPR3 0.47 7.41 0.38 1.09e-12 Height; CRC cis rs6502050 0.835 rs8077772 chr17:80117220 A/G cg13939156 chr17:80058883 NA 0.36 5.73 0.3 2.26e-8 Life satisfaction; CRC cis rs10540 1.000 rs71487296 chr11:500282 G/A cg21784768 chr11:537496 LRRC56 -0.69 -6.58 -0.34 1.88e-10 Body mass index; CRC cis rs853679 0.517 rs9368551 chr6:28061792 A/G cg23161317 chr6:28129485 ZNF389 0.52 6.35 0.33 6.97e-10 Depression; CRC cis rs79349575 0.594 rs62078375 chr17:47034974 A/G cg00947319 chr17:47005597 UBE2Z -0.34 -5.76 -0.3 1.95e-8 Type 2 diabetes; CRC cis rs2976388 0.647 rs2082801 chr8:143786461 A/G cg15511327 chr8:143859410 LYNX1 0.41 7.33 0.37 1.83e-12 Urinary tract infection frequency; CRC cis rs11212617 0.967 rs227090 chr11:108241349 G/T cg14761454 chr11:108092087 ATM;NPAT 0.39 5.67 0.3 3.09e-8 Response to metformin in type 2 diabetes (glycemic); CRC cis rs6922632 1.000 rs28921123 chr6:24126112 G/A cg26194775 chr6:24126114 NRSN1 -0.9 -8.87 -0.44 4.87e-17 Information processing speed; CRC trans rs11039798 0.557 rs4436575 chr11:48398894 T/C cg03929089 chr4:120376271 NA -0.63 -6.58 -0.34 1.86e-10 Axial length; CRC trans rs7829975 0.714 rs11784052 chr8:8671962 C/T cg20542592 chr8:11973495 FAM66D -0.35 -6.05 -0.32 4.01e-9 Mood instability; CRC cis rs116095464 0.558 rs13356367 chr5:242395 C/T cg22857025 chr5:266934 NA -1.25 -16.72 -0.68 7.27e-46 Breast cancer; CRC cis rs28830936 0.966 rs1918310 chr15:42065253 A/C cg17847044 chr15:42102381 MAPKBP1 -0.31 -6.33 -0.33 8.23e-10 Diastolic blood pressure; CRC trans rs7937682 0.883 rs490492 chr11:111465150 C/T cg18187862 chr3:45730750 SACM1L 0.43 6.14 0.32 2.38e-9 Primary sclerosing cholangitis; CRC cis rs7202877 0.611 rs4888395 chr16:75413715 T/G cg03315344 chr16:75512273 CHST6 0.5 5.7 0.3 2.71e-8 Type 2 diabetes;Type 1 diabetes; CRC cis rs4654899 0.772 rs951805 chr1:21060356 A/G cg02927042 chr1:21476669 EIF4G3 0.49 7.54 0.38 4.72e-13 Superior frontal gyrus grey matter volume; CRC cis rs4718428 0.705 rs62465692 chr7:66295745 T/C cg12165864 chr7:66369176 NA -0.41 -5.62 -0.3 4.07e-8 Corneal structure; CRC trans rs11581859 0.950 rs72730310 chr1:99377948 A/C cg12183875 chr3:169587454 LRRC31 0.27 6.2 0.32 1.74e-9 Response to cognitive-behavioural therapy in anxiety disorder; CRC cis rs941873 0.868 rs10740497 chr10:81126380 T/C cg09469691 chr10:81107165 PPIF 0.58 9.37 0.46 1.18e-18 Height; CRC cis rs2760061 0.626 rs596208 chr1:228117982 G/C cg02753203 chr1:228287806 NA -0.65 -9.94 -0.48 1.57e-20 Diastolic blood pressure; CRC cis rs6912958 0.781 rs4707376 chr6:88270947 A/G cg08069147 chr6:88032118 GJB7;C6orf162 -0.56 -8.34 -0.42 2.07e-15 Monocyte percentage of white cells; CRC cis rs7258465 0.965 rs7256534 chr19:18586791 C/T cg06462663 chr19:18546047 ISYNA1 0.49 7.44 0.38 8.94e-13 Breast cancer; CRC cis rs9308731 0.583 rs6726007 chr2:111932122 A/T cg04202892 chr2:111875749 ACOXL 0.42 6.73 0.35 7.37e-11 Chronic lymphocytic leukemia; CRC cis rs13108904 0.870 rs2291199 chr4:1244267 A/G cg23123621 chr4:1343375 KIAA1530 0.33 5.75 0.3 2.07e-8 Obesity-related traits; CRC cis rs55665837 0.961 rs12576926 chr11:14480292 C/T cg19336497 chr11:14380999 RRAS2 -0.39 -6.55 -0.34 2.16e-10 Vitamin D levels; CRC trans rs12660387 1.000 rs12663626 chr6:65264646 A/T cg13393512 chr9:135749454 C9orf98 0.51 5.96 0.31 6.5e-9 Schizophrenia; CRC cis rs7615952 0.599 rs6803160 chr3:125709554 G/T cg02807482 chr3:125708958 NA -0.45 -5.89 -0.31 9.73e-9 Blood pressure (smoking interaction); CRC cis rs9311474 0.581 rs13621 chr3:52558133 T/C cg10802521 chr3:52805072 NEK4 -0.52 -8.33 -0.42 2.25e-15 Electroencephalogram traits; CRC cis rs4721295 0.502 rs2058430 chr7:2206110 A/G cg08027265 chr7:2291960 NA -0.38 -5.99 -0.31 5.41e-9 Schizophrenia, schizoaffective disorder or bipolar disorder; CRC cis rs951366 0.789 rs823095 chr1:205679239 G/A cg17178900 chr1:205818956 PM20D1 0.66 9.34 0.46 1.49e-18 Menarche (age at onset); CRC cis rs6032067 0.929 rs35869085 chr20:43805134 G/C cg10761708 chr20:43804764 PI3 0.51 5.89 0.31 9.53e-9 Blood protein levels; CRC cis rs6963495 0.818 rs73190181 chr7:105162907 A/C cg13798780 chr7:105162888 PUS7 0.68 8.08 0.41 1.27e-14 Bipolar disorder (body mass index interaction); CRC cis rs4713118 0.586 rs9468290 chr6:28087674 C/T cg03623178 chr6:28175578 NA 0.95 12.17 0.56 2.13e-28 Parkinson's disease; CRC cis rs9611565 0.512 rs964898 chr22:42142306 C/T cg06634786 chr22:41940651 POLR3H -0.67 -7.61 -0.39 2.86e-13 Vitiligo; CRC cis rs1401999 0.966 rs2139560 chr3:183653869 A/G cg01324343 chr3:183735012 ABCC5 0.82 14.95 0.64 6.37e-39 Anterior chamber depth; CRC cis rs9443645 0.527 rs10943600 chr6:79611505 G/A cg09184832 chr6:79620586 NA -0.47 -8.24 -0.41 4.1e-15 Intelligence (multi-trait analysis); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg10457504 chr17:19281708 MAPK7 0.45 6.8 0.35 4.8e-11 Intelligence (multi-trait analysis); CRC cis rs7258465 0.965 rs271622 chr19:18629277 A/G cg01065977 chr19:18549689 ISYNA1 -0.37 -5.66 -0.3 3.3e-8 Breast cancer; CRC cis rs2050392 0.928 rs2250077 chr10:30702929 A/G cg25182066 chr10:30743637 MAP3K8 -0.39 -5.8 -0.3 1.59e-8 Inflammatory bowel disease; CRC cis rs6674970 0.933 rs11204772 chr1:151056305 C/T cg11822372 chr1:151115635 SEMA6C 0.53 7.59 0.39 3.39e-13 Childhood ear infection; CRC cis rs1799949 0.965 rs8176310 chr17:41199913 T/C cg23758822 chr17:41437982 NA 0.92 18.56 0.72 3.96e-53 Menopause (age at onset); CRC cis rs514406 0.893 rs1242326 chr1:53399104 C/A cg24675658 chr1:53192096 ZYG11B -0.58 -8.53 -0.43 5.35e-16 Monocyte count; CRC cis rs2228479 0.717 rs1061647 chr16:89806063 G/C cg06558623 chr16:89946397 TCF25 1.16 10.95 0.52 5.2e-24 Skin colour saturation; CRC cis rs4665809 1.000 rs6729757 chr2:26285102 A/G cg27170947 chr2:26402098 FAM59B -0.45 -5.94 -0.31 7.45e-9 Gut microbiome composition (summer); CRC cis rs2404602 0.684 rs8037847 chr15:76856551 C/T cg23625390 chr15:77176239 SCAPER -0.86 -14.21 -0.62 4.44e-36 Blood metabolite levels; CRC cis rs10540 1.000 rs61876334 chr11:487201 T/C cg08200582 chr11:442649 ANO9 -0.7 -7.07 -0.36 9.14e-12 Body mass index; CRC cis rs12760731 0.641 rs10798605 chr1:178294872 G/A cg00404053 chr1:178313656 RASAL2 0.82 9.9 0.48 2.17e-20 Obesity-related traits; CRC cis rs2832191 0.740 rs2832175 chr21:30475606 A/G cg24692254 chr21:30365293 RNF160 -0.82 -15.34 -0.65 1.86e-40 Dental caries; CRC trans rs7395662 0.963 rs2865923 chr11:48724955 G/A cg21153622 chr11:89784906 NA -0.48 -7.72 -0.39 1.45e-13 HDL cholesterol; CRC cis rs4975616 0.804 rs456366 chr5:1337070 T/C cg26373071 chr5:1325741 CLPTM1L 0.55 9.97 0.48 1.23e-20 Lung cancer; CRC cis rs4689592 0.622 rs2276968 chr4:7070118 T/G cg19539972 chr4:7069911 GRPEL1 0.85 10.38 0.5 4.96e-22 Monocyte percentage of white cells; CRC cis rs9926296 0.546 rs6500442 chr16:89828862 T/C cg04287289 chr16:89883240 FANCA 0.81 14.31 0.62 1.89e-36 Vitiligo; CRC cis rs2832191 0.632 rs2246777 chr21:30309586 T/C cg24692254 chr21:30365293 RNF160 -0.85 -15.08 -0.64 2.05e-39 Dental caries; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg03462115 chr16:29801729 KIF22 0.48 7.61 0.39 2.84e-13 Liver disease severity in Alagille syndrome; CRC cis rs10751667 0.666 rs10902239 chr11:946484 A/G cg06064525 chr11:970664 AP2A2 0.31 6.33 0.33 8.26e-10 Alzheimer's disease (late onset); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg23486179 chr3:49466665 NICN1 0.48 7.94 0.4 3.16e-14 Liver disease severity in Alagille syndrome; CRC cis rs6694672 1.000 rs6003 chr1:197031021 C/T cg13682187 chr1:196946512 CFHR5 0.45 7.16 0.37 5.15e-12 Asthma; CRC cis rs1538970 1.000 rs4520450 chr1:45834773 A/G cg05343316 chr1:45956843 TESK2 0.68 8.98 0.44 2.15e-17 Platelet count; CRC cis rs9443645 0.901 rs9352683 chr6:79718795 T/G cg09184832 chr6:79620586 NA -0.51 -9.28 -0.46 2.3e-18 Intelligence (multi-trait analysis); CRC trans rs9291683 0.588 rs3733586 chr4:9997534 C/T cg26043149 chr18:55253948 FECH 0.5 7.79 0.39 8.99e-14 Bone mineral density; CRC cis rs2404602 0.583 rs4381566 chr15:76589262 A/G cg22467129 chr15:76604101 ETFA -0.47 -8.25 -0.41 3.75e-15 Blood metabolite levels; CRC cis rs9910055 0.529 rs850851 chr17:42177674 C/T cg19774624 chr17:42201019 HDAC5 0.43 5.61 0.3 4.2e-8 Total body bone mineral density; CRC cis rs9322193 0.884 rs9480009 chr6:150079638 A/G cg13206674 chr6:150067644 NUP43 0.68 10.28 0.49 1.08e-21 Lung cancer; CRC cis rs11690935 1.000 rs11678984 chr2:172535848 T/G cg13550731 chr2:172543902 DYNC1I2 1.06 19.24 0.73 8.72e-56 Schizophrenia; CRC cis rs3540 0.576 rs10152871 chr15:91047469 G/A cg22089800 chr15:90895588 ZNF774 -0.58 -9.64 -0.47 1.53e-19 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; CRC cis rs9611565 0.765 rs132905 chr22:41799106 C/A cg06481639 chr22:41940642 POLR3H 0.5 5.83 0.31 1.34e-8 Vitiligo; CRC cis rs898097 0.737 rs3785521 chr17:80895769 A/G cg15664640 chr17:80829946 TBCD 0.66 10.38 0.5 5.25e-22 Breast cancer; CRC cis rs7662987 0.517 rs3018047 chr4:100014510 C/T cg12011299 chr4:100065546 ADH4 -0.46 -8.55 -0.43 4.68e-16 Smoking initiation; CRC cis rs2115630 0.691 rs8040066 chr15:85176465 G/C cg09876464 chr15:85330779 ZNF592 0.39 6.5 0.34 2.99e-10 P wave terminal force; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg00267196 chr8:135710113 ZFAT 0.44 6.71 0.35 8.66e-11 Liver disease severity in Alagille syndrome; CRC cis rs12220238 1.000 rs12355771 chr10:75894404 C/T cg19889307 chr10:75911429 ADK;AP3M1 0.61 5.66 0.3 3.24e-8 Soluble interleukin-2 receptor subunit alpha; CRC trans rs6550704 0.687 rs9865314 chr3:22634337 A/G cg06905471 chr2:29092871 TRMT61B -0.42 -6.12 -0.32 2.65e-9 Daytime sleep phenotypes; CRC cis rs6952808 0.594 rs3778969 chr7:2139990 A/G cg04267008 chr7:1944627 MAD1L1 0.67 9.38 0.46 1.11e-18 Bipolar disorder and schizophrenia; CRC cis rs12142240 0.698 rs17361833 chr1:46828700 A/G cg00530320 chr1:46809349 NSUN4 0.59 8.11 0.41 1.02e-14 Menopause (age at onset); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg23661306 chr3:57541993 PDE12 0.43 7.09 0.36 8.08e-12 Liver disease severity in Alagille syndrome; CRC cis rs6938 0.534 rs1133322 chr15:75212357 A/G cg09165964 chr15:75287851 SCAMP5 0.63 10.29 0.49 1.07e-21 Breast cancer; CRC cis rs977987 0.806 rs4888425 chr16:75476363 T/C cg03315344 chr16:75512273 CHST6 0.55 9.27 0.45 2.58e-18 Dupuytren's disease; CRC cis rs10504229 0.683 rs2873638 chr8:58114593 G/A cg24829409 chr8:58192753 C8orf71 -0.54 -7.88 -0.4 4.9e-14 Developmental language disorder (linguistic errors); CRC cis rs929354 0.742 rs1182396 chr7:157031831 A/C cg05182265 chr7:156933206 UBE3C 0.76 14.46 0.62 4.88e-37 Body mass index; CRC trans rs3733655 0.545 rs7674790 chr4:31149277 A/T cg00008713 chr18:11980953 IMPA2 -0.44 -5.98 -0.31 5.68e-9 White matter hyperintensities in ischemic stroke; CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg14387610 chr18:59854615 PIGN;KIAA1468 0.38 6.1 0.32 3.03e-9 Obesity-related traits; CRC cis rs919433 0.963 rs12469546 chr2:198178826 T/C cg20885578 chr2:198174922 NA -0.42 -6.81 -0.35 4.68e-11 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC cis rs7617773 0.539 rs12486944 chr3:48390016 G/A cg11946769 chr3:48343235 NME6 0.61 8.29 0.42 2.86e-15 Coronary artery disease; CRC cis rs2075371 1.000 rs2241335 chr7:133979368 C/T cg02659138 chr7:134003124 SLC35B4 0.39 6.83 0.35 4.1e-11 Mean platelet volume; CRC cis rs67311347 1.000 rs11716675 chr3:40485280 G/T cg09455208 chr3:40491958 NA 0.43 8.72 0.43 1.36e-16 Renal cell carcinoma; CRC cis rs11098499 0.644 rs10012252 chr4:120559139 T/C cg24375607 chr4:120327624 NA 0.46 7.2 0.37 4.17e-12 Corneal astigmatism; CRC cis rs644148 0.785 rs2140111 chr19:44973019 A/C cg15540054 chr19:45004280 ZNF180 -0.55 -7.1 -0.36 7.5e-12 Personality dimensions; CRC cis rs11997175 0.653 rs7005254 chr8:33641781 A/T ch.8.33884649F chr8:33765107 NA 0.41 6.44 0.33 4.29e-10 Body mass index; CRC cis rs2836974 0.666 rs1888487 chr21:40683259 A/G cg22974920 chr21:40686053 BRWD1 -0.44 -6.09 -0.32 3.1e-9 Cognitive function; CRC cis rs10946940 1.000 rs10946940 chr6:27560587 A/G cg20933634 chr6:27740509 NA -0.39 -5.66 -0.3 3.26e-8 Systemic lupus erythematosus; CRC cis rs11252926 0.589 rs12359901 chr10:475068 A/G cg03684893 chr10:554711 DIP2C 0.34 5.66 0.3 3.28e-8 Psychosis in Alzheimer's disease; CRC cis rs7937682 0.924 rs4630327 chr11:111539327 C/T cg19812747 chr11:111475976 SIK2 0.54 9.56 0.47 2.88e-19 Primary sclerosing cholangitis; CRC cis rs4665809 0.590 rs66477033 chr2:26472497 T/C cg26119090 chr2:26468346 HADHA;HADHB 1.06 15.53 0.65 3.62e-41 Gut microbiome composition (summer); CRC cis rs8141529 0.748 rs5752826 chr22:29269808 A/G cg02153584 chr22:29168773 CCDC117 0.47 6.78 0.35 5.59e-11 Lymphocyte counts; CRC cis rs1799949 1.000 rs8176109 chr17:41265776 A/G cg05368731 chr17:41323189 NBR1 0.69 10.51 0.5 1.81e-22 Menopause (age at onset); CRC trans rs8002861 0.934 rs9533685 chr13:44468331 A/G cg17145862 chr1:211918768 LPGAT1 0.78 15.75 0.66 4.75e-42 Leprosy; CRC trans rs13046373 0.905 rs4816372 chr21:32077414 A/T cg05296866 chr19:5906773 VMAC -0.39 -6.12 -0.32 2.73e-9 HDL cholesterol; CRC cis rs7618915 0.501 rs13079063 chr3:52744460 A/G cg15147215 chr3:52552868 STAB1 -0.63 -10.59 -0.5 9.9e-23 Bipolar disorder; CRC cis rs4713118 0.516 rs6931858 chr6:28078411 A/T cg03623178 chr6:28175578 NA 0.89 11.13 0.52 1.25e-24 Parkinson's disease; CRC cis rs7172809 0.897 rs17394448 chr15:77825149 C/A cg10437265 chr15:77819839 NA -0.42 -7.15 -0.37 5.73e-12 Glucose homeostasis traits; CRC cis rs7618915 0.501 rs11714030 chr3:52765882 C/T cg15147215 chr3:52552868 STAB1 -0.62 -10.72 -0.51 3.45e-23 Bipolar disorder; CRC cis rs78663649 0.522 rs117196542 chr19:16578257 G/A cg10248733 chr19:16607483 C19orf44;CALR3 -0.89 -5.91 -0.31 8.79e-9 White blood cell count; CRC cis rs6998277 1.000 rs4281092 chr8:103647956 A/G cg10187029 chr8:103597600 NA -0.79 -10.44 -0.5 3.15e-22 Migraine; CRC cis rs7149337 0.717 rs4309324 chr14:51606336 A/T cg23942311 chr14:51606299 NA -0.74 -12.94 -0.58 3.18e-31 Cancer; CRC cis rs4253772 0.591 rs9615934 chr22:46682310 C/G cg24881330 chr22:46731750 TRMU 0.61 5.93 0.31 7.66e-9 LDL cholesterol;Cholesterol, total; CRC cis rs1451375 0.617 rs896307 chr7:50569060 T/C cg14593290 chr7:50529359 DDC -0.62 -8.26 -0.41 3.57e-15 Malaria; CRC cis rs2124969 0.562 rs13393480 chr2:161058790 G/T cg03641300 chr2:160917029 PLA2R1 -0.57 -9.31 -0.46 1.82e-18 Waist circumference adjusted for body mass index; CRC cis rs6461049 0.800 rs3800913 chr7:2163237 A/G cg08027265 chr7:2291960 NA -0.37 -6.38 -0.33 6.06e-10 Schizophrenia; CRC cis rs4332037 0.707 rs4721096 chr7:1877311 T/C cg23378565 chr7:2036160 MAD1L1 0.39 5.63 0.3 3.87e-8 Bipolar disorder; CRC cis rs7215564 0.908 rs34135683 chr17:78652903 G/T cg09596252 chr17:78655493 RPTOR 0.54 5.7 0.3 2.7e-8 Myopia (pathological); CRC cis rs4927850 0.709 rs6783079 chr3:195652708 T/C cg12923728 chr3:195709715 SDHAP1 -0.69 -9.1 -0.45 8.57e-18 Pancreatic cancer; CRC cis rs8141529 0.636 rs5762813 chr22:29203314 C/T cg15103426 chr22:29168792 CCDC117 0.48 5.91 0.31 8.6e-9 Lymphocyte counts; CRC cis rs1448094 0.512 rs6539933 chr12:86247611 T/C cg00310523 chr12:86230176 RASSF9 0.35 5.85 0.31 1.16e-8 Major depressive disorder; CRC cis rs769267 0.965 rs4808938 chr19:19401218 G/A cg20644253 chr19:19431407 KIAA0892;SF4 0.42 5.88 0.31 1.01e-8 Tonsillectomy; CRC cis rs3768617 0.510 rs10752896 chr1:183068516 A/C ch.1.3577855R chr1:183094577 LAMC1 0.86 15.13 0.64 1.3e-39 Fuchs's corneal dystrophy; CRC cis rs7772486 0.720 rs6931553 chr6:146112348 T/C cg13319975 chr6:146136371 FBXO30 0.46 6.67 0.35 1.07e-10 Lobe attachment (rater-scored or self-reported); CRC cis rs7945718 0.967 rs10741602 chr11:12761699 A/T cg25843174 chr11:12811716 TEAD1 0.49 9.16 0.45 5.55e-18 Educational attainment (years of education); CRC cis rs17209837 0.920 rs17149652 chr7:87087187 G/T cg00919237 chr7:87102261 ABCB4 -0.49 -6.03 -0.32 4.4e-9 Gallbladder cancer; CRC cis rs4434138 0.664 rs62255364 chr3:52701502 C/T cg18404041 chr3:52824283 ITIH1 -0.43 -8.73 -0.43 1.3e-16 Intelligence (multi-trait analysis); CRC cis rs9905704 0.918 rs2567901 chr17:56783255 C/T cg12560992 chr17:57184187 TRIM37 0.53 7.31 0.37 1.99e-12 Testicular germ cell tumor; CRC cis rs13108904 0.967 rs4974582 chr4:1279687 C/T cg00684032 chr4:1343700 KIAA1530 0.48 7.02 0.36 1.3e-11 Obesity-related traits; CRC trans rs2243480 0.901 rs313808 chr7:65499873 T/G cg10756647 chr7:56101905 PSPH 0.78 8.33 0.42 2.14e-15 Diabetic kidney disease; CRC cis rs10504229 0.815 rs72650879 chr8:58164648 A/G cg22535103 chr8:58192502 C8orf71 -0.73 -8.63 -0.43 2.64e-16 Developmental language disorder (linguistic errors); CRC cis rs7727544 0.904 rs7736102 chr5:131604257 G/A cg18758796 chr5:131593413 PDLIM4 0.33 6.16 0.32 2.09e-9 Blood metabolite levels; CRC cis rs7552404 0.727 rs1146653 chr1:76280438 A/G cg22875332 chr1:76189707 ACADM 0.56 7.71 0.39 1.55e-13 Blood metabolite levels;Acylcarnitine levels; CRC cis rs4589502 0.841 rs56401320 chr15:67140517 C/G cg12317470 chr15:67143691 NA 0.73 6.4 0.33 5.37e-10 Lung cancer (smoking interaction); CRC trans rs60843830 1.000 rs17714252 chr2:285471 G/A cg11347411 chr7:150020925 ACTR3C;LRRC61 0.59 9.17 0.45 5.25e-18 Spherical equivalent (joint analysis main effects and education interaction); CRC cis rs2239547 0.657 rs4687672 chr3:52880543 G/A cg15147215 chr3:52552868 STAB1 -0.41 -5.75 -0.3 2.04e-8 Schizophrenia; CRC cis rs11711311 0.911 rs9831422 chr3:113398195 G/A cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.51 -6.68 -0.35 1.02e-10 IgG glycosylation; CRC cis rs9467773 1.000 rs1884949 chr6:26568067 G/A cg09904177 chr6:26538194 HMGN4 0.86 14.82 0.63 2.06e-38 Intelligence (multi-trait analysis); CRC cis rs17401966 0.894 rs11587309 chr1:10446596 G/T cg19773385 chr1:10388646 KIF1B -0.67 -10.23 -0.49 1.71e-21 Hepatocellular carcinoma; CRC cis rs7264396 0.887 rs3818441 chr20:34046501 G/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.39 -6.41 -0.33 5.12e-10 Total cholesterol levels; CRC cis rs6558174 0.965 rs6558172 chr8:22492052 C/T cg03733263 chr8:22462867 KIAA1967 0.49 6.73 0.35 7.49e-11 Breast cancer; CRC cis rs4713118 0.869 rs9461400 chr6:27700559 A/G cg19041857 chr6:27730383 NA -0.41 -6.0 -0.31 5.3300000000000004e-09 Parkinson's disease; CRC cis rs7527798 0.592 rs960087 chr1:207826858 C/G cg09232269 chr1:207846808 CR1L -0.51 -8.26 -0.41 3.62e-15 Erythrocyte sedimentation rate; CRC cis rs2836974 0.931 rs8132285 chr21:40655752 T/C cg11644478 chr21:40555479 PSMG1 0.81 12.32 0.56 6.05e-29 Cognitive function; CRC cis rs6088590 1.000 rs6120750 chr20:33465289 A/C cg24642439 chr20:33292090 TP53INP2 0.51 8.74 0.43 1.21e-16 Coronary artery disease; CRC cis rs2204008 0.837 rs4312131 chr12:38181087 G/T cg26384229 chr12:38710491 ALG10B 0.71 9.53 0.47 3.56e-19 Bladder cancer; CRC cis rs763014 0.966 rs4984904 chr16:680809 C/G cg04562611 chr16:615315 C16orf11 0.37 6.19 0.32 1.81e-9 Height; CRC cis rs9527 0.590 rs12414232 chr10:104914491 A/T cg04362960 chr10:104952993 NT5C2 0.6 8.32 0.42 2.32e-15 Arsenic metabolism; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg18743068 chr10:94831650 NA 0.43 6.65 0.34 1.2e-10 Response to antipsychotic treatment; CRC cis rs2075371 0.966 rs1901204 chr7:133985896 A/G cg02659138 chr7:134003124 SLC35B4 0.39 6.79 0.35 5.23e-11 Mean platelet volume; CRC cis rs7618501 0.521 rs952594 chr3:49908023 G/A cg24110177 chr3:50126178 RBM5 -0.61 -9.4 -0.46 9.36e-19 Intelligence (multi-trait analysis); CRC cis rs2857891 0.909 rs56026267 chr11:6940211 T/C cg22096450 chr11:6947773 ZNF215 0.58 6.01 0.31 4.99e-9 Response to cytadine analogues (cytosine arabinoside); CRC cis rs4481887 0.927 rs4390209 chr1:248472613 A/T cg13385794 chr1:248469461 NA 0.38 6.75 0.35 6.84e-11 Common traits (Other); CRC cis rs61160187 0.582 rs67555188 chr5:60143228 T/G cg16298547 chr5:60138761 ELOVL7 -0.28 -5.77 -0.3 1.78e-8 Educational attainment (years of education);Educational attainment (college completion); CRC cis rs4363385 0.553 rs1415972 chr1:152953552 A/G cg25856811 chr1:152973957 SPRR3 0.23 6.22 0.32 1.5e-9 Inflammatory skin disease; CRC cis rs9341808 0.538 rs688867 chr6:80939228 A/G cg08355045 chr6:80787529 NA 0.35 5.85 0.31 1.19e-8 Sitting height ratio; CRC cis rs11679072 1.000 rs6740692 chr2:240448525 A/G cg03276489 chr2:240449683 NA -0.93 -9.41 -0.46 8.71e-19 Blood pressure (smoking interaction); CRC cis rs13108904 0.517 rs13128825 chr4:1334007 G/A cg20092199 chr4:1342459 KIAA1530 0.45 7.31 0.37 2.04e-12 Obesity-related traits; CRC cis rs877282 0.891 rs12767043 chr10:797943 C/T cg06581033 chr10:766294 NA -0.51 -5.7 -0.3 2.72e-8 Uric acid levels; CRC cis rs28386778 0.897 rs2236736 chr17:61938248 G/T cg23090583 chr17:61904693 PSMC5;FTSJ3 1.03 20.12 0.74 2.81e-59 Prudent dietary pattern; CRC cis rs7605827 0.930 rs6740183 chr2:15692583 T/C cg19274914 chr2:15703543 NA 0.39 5.82 0.31 1.4e-8 Educational attainment (years of education); CRC cis rs847649 0.692 rs6969054 chr7:102446569 T/C cg18108683 chr7:102477205 FBXL13 -0.67 -11.29 -0.53 3.37e-25 Morning vs. evening chronotype; CRC trans rs1005277 0.579 rs2023351 chr10:38378814 A/G cg23533926 chr12:111358616 MYL2 -0.52 -7.83 -0.4 6.57e-14 Extrinsic epigenetic age acceleration; CRC trans rs1814175 0.645 rs28549248 chr11:50042740 C/T cg03929089 chr4:120376271 NA -0.89 -15.95 -0.66 7.68e-43 Height; CRC cis rs1949733 0.656 rs2688224 chr4:8404700 C/G cg13073564 chr4:8508604 NA -0.46 -7.11 -0.36 7.34e-12 Response to antineoplastic agents; CRC cis rs2576037 0.526 rs4890703 chr18:44522037 A/G cg19077165 chr18:44547161 KATNAL2 -0.56 -8.62 -0.43 2.8e-16 Personality dimensions; CRC cis rs11098499 0.909 rs1546504 chr4:120241179 C/T cg24375607 chr4:120327624 NA 0.49 7.35 0.38 1.63e-12 Corneal astigmatism; CRC cis rs2404602 0.583 rs2469542 chr15:76557476 A/G cg03037974 chr15:76606532 NA -0.75 -14.36 -0.62 1.27e-36 Blood metabolite levels; CRC cis rs853679 0.517 rs9393890 chr6:28063855 C/T cg12172441 chr6:28176163 NA 0.62 7.33 0.37 1.76e-12 Depression; CRC cis rs3760982 0.813 rs10426528 chr19:44299298 A/G cg11993925 chr19:44307056 LYPD5 0.45 7.62 0.39 2.79e-13 Breast cancer (estrogen-receptor negative);Breast cancer; CRC cis rs2797160 1.000 rs1739377 chr6:126012236 T/C cg05901451 chr6:126070800 HEY2 0.4 6.14 0.32 2.35e-9 Endometrial cancer; CRC cis rs10979 0.603 rs9321920 chr6:143883588 C/G cg25407410 chr6:143891975 LOC285740 -0.71 -9.99 -0.48 1.07e-20 Hypospadias; CRC trans rs2553218 0.690 rs8032415 chr15:54851945 A/G cg18879991 chr6:27861393 HIST1H2AM;HIST1H2BO 0.47 6.28 0.33 1.04e-9 Immune response to smallpox vaccine (IL-6); CRC cis rs868943 0.743 rs4628134 chr6:116360141 A/G cg18764771 chr6:116381957 FRK 0.24 5.92 0.31 8.2e-9 Total cholesterol levels; CRC cis rs597583 0.715 rs2276340 chr11:117391966 G/A cg27161313 chr11:117392002 DSCAML1 -0.47 -5.98 -0.31 5.73e-9 Putamen volume; CRC cis rs910316 0.789 rs175444 chr14:75601782 G/C cg08847533 chr14:75593920 NEK9 -0.84 -14.61 -0.63 1.31e-37 Height; CRC cis rs4523957 0.928 rs10852932 chr17:2143460 G/T cg16513277 chr17:2031491 SMG6 -0.52 -8.76 -0.43 1.05e-16 Autism spectrum disorder or schizophrenia;Schizophrenia; CRC cis rs11758351 0.587 rs10484436 chr6:26237155 C/T cg08260959 chr6:26240920 HIST1H4F -0.36 -5.73 -0.3 2.25e-8 Gout;Renal underexcretion gout; CRC cis rs7945718 0.781 rs10741604 chr11:12840940 C/A cg25843174 chr11:12811716 TEAD1 0.5 9.21 0.45 3.85e-18 Educational attainment (years of education); CRC cis rs3820068 0.581 rs72645890 chr1:15930602 A/G cg27534772 chr1:16042836 PLEKHM2 0.54 10.46 0.5 2.7e-22 Systolic blood pressure; CRC cis rs60871478 0.945 rs62432254 chr7:804175 C/T cg13844804 chr7:814759 HEATR2 0.65 8.47 0.42 8.48e-16 Cerebrospinal P-tau181p levels; CRC cis rs11123610 0.520 rs7576701 chr2:3718227 T/C cg25251562 chr2:3704773 ALLC -0.49 -6.12 -0.32 2.62e-9 Response to inhaled corticosteroid treatment in asthma (change in FEV1); CRC cis rs763121 0.853 rs2072795 chr22:39064209 A/G cg06544989 chr22:39130855 UNC84B -0.46 -7.15 -0.37 5.69e-12 Menopause (age at onset); CRC cis rs9517320 0.517 rs4772097 chr13:99194652 C/A cg07423050 chr13:99094983 FARP1 -0.54 -7.53 -0.38 4.87e-13 Longevity; CRC cis rs853679 0.550 rs1225598 chr6:28160799 T/G cg15845792 chr6:28175446 NA 1.02 15.66 0.65 1.12e-41 Depression; CRC cis rs2836974 0.831 rs2836964 chr21:40631006 T/C cg11644478 chr21:40555479 PSMG1 0.81 12.32 0.56 6.37e-29 Cognitive function; CRC cis rs6951245 0.872 rs75280240 chr7:1058511 C/T cg24642844 chr7:1081250 C7orf50 -0.74 -8.92 -0.44 3.35e-17 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs9303401 0.614 rs35308719 chr17:57163501 C/T cg10487724 chr17:56770010 TEX14;RAD51C 0.69 8.54 0.43 5.13e-16 Cognitive test performance; CRC cis rs11098499 0.954 rs28572238 chr4:120316686 T/G cg09307838 chr4:120376055 NA 0.71 10.84 0.51 1.34e-23 Corneal astigmatism; CRC cis rs13064411 0.597 rs2291905 chr3:113010466 C/T cg10517650 chr3:113235015 CCDC52 -0.34 -6.12 -0.32 2.72e-9 Response to simvastatin treatment (PCSK9 protein level change); CRC cis rs425277 0.628 rs10797427 chr1:2060732 C/T cg24578937 chr1:2090814 PRKCZ -0.39 -7.29 -0.37 2.3e-12 Height; CRC cis rs853679 0.542 rs9393892 chr6:28081394 A/G cg15845792 chr6:28175446 NA 0.99 13.05 0.58 1.19e-31 Depression; CRC cis rs853679 0.517 rs9380065 chr6:28144751 A/G cg18032046 chr6:28092343 ZSCAN16 -0.52 -5.93 -0.31 7.58e-9 Depression; CRC cis rs7044106 0.762 rs10491783 chr9:123450155 C/G cg09419670 chr9:123605666 PSMD5;LOC253039 0.7 11.58 0.54 3.07e-26 Hip circumference adjusted for BMI; CRC cis rs12580194 0.957 rs12579451 chr12:55694116 C/T cg19537932 chr12:55886519 OR6C68 -0.51 -6.5 -0.34 3.01e-10 Cancer; CRC cis rs3736485 0.844 rs56189052 chr15:51822378 T/G cg08986416 chr15:51914746 DMXL2 -0.44 -6.18 -0.32 1.87e-9 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs1008375 1.000 rs6848360 chr4:17634442 G/T cg16339924 chr4:17578868 LAP3 0.54 7.05 0.36 1.03e-11 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs9463078 0.525 rs9395058 chr6:44984069 T/A cg25276700 chr6:44698697 NA -0.25 -6.04 -0.32 4.16e-9 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; CRC cis rs305851 0.875 rs9369136 chr6:39758887 C/T cg02386599 chr6:39769542 DAAM2 -0.37 -5.72 -0.3 2.38e-8 Lobe attachment (rater-scored or self-reported); CRC cis rs7937682 0.961 rs4936682 chr11:111629743 T/G cg09085632 chr11:111637200 PPP2R1B 1.07 20.4 0.75 2.24e-60 Primary sclerosing cholangitis; CRC cis rs12449964 0.524 rs4925094 chr17:17569012 C/T cg16928487 chr17:17741425 SREBF1 0.37 6.33 0.33 8.16e-10 Coronary artery disease or ischemic stroke; CRC cis rs3126085 0.799 rs11589532 chr1:152176539 G/A cg09127314 chr1:152161683 NA -0.51 -5.89 -0.31 9.59e-9 Atopic dermatitis; CRC cis rs7618915 0.547 rs34215106 chr3:52659124 T/C cg08222913 chr3:52553049 STAB1 -0.34 -6.12 -0.32 2.65e-9 Bipolar disorder; CRC cis rs7833790 0.724 rs10958045 chr8:82722994 T/C cg27398817 chr8:82754497 SNX16 -0.44 -6.06 -0.32 3.76e-9 Diastolic blood pressure; CRC cis rs10791097 0.694 rs4370948 chr11:130755700 A/C cg12179176 chr11:130786555 SNX19 0.75 12.42 0.56 2.72e-29 Autism spectrum disorder or schizophrenia;Schizophrenia; CRC cis rs2404602 0.692 rs1116535 chr15:77009514 C/G cg03037974 chr15:76606532 NA -0.69 -12.1 -0.56 3.82e-28 Blood metabolite levels; CRC cis rs990171 1.000 rs7597819 chr2:103092906 A/G cg03938978 chr2:103052716 IL18RAP 0.46 5.73 0.3 2.28e-8 Lymphocyte counts; CRC cis rs7512552 0.839 rs3820544 chr1:150457876 A/T cg15654264 chr1:150340011 RPRD2 0.61 8.36 0.42 1.83e-15 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); CRC cis rs7647973 0.593 rs55997059 chr3:49858661 A/T cg13072238 chr3:49761600 GMPPB 0.49 5.84 0.31 1.26e-8 Menarche (age at onset); CRC cis rs7666738 0.830 rs113999196 chr4:99041961 C/T cg17366294 chr4:99064904 C4orf37 0.45 7.73 0.39 1.34e-13 Colonoscopy-negative controls vs population controls; CRC cis rs9491140 0.539 rs911959 chr6:124688755 A/G cg19267163 chr6:125004984 NKAIN2 0.48 6.7 0.35 9e-11 Neuroticism; CRC cis rs4400599 1.000 rs4845364 chr1:154141908 A/G cg05139571 chr1:154127138 NUP210L 0.43 6.51 0.34 2.76e-10 Platelet distribution width; CRC trans rs8073060 0.586 rs226084 chr17:34019582 T/A cg19694781 chr19:47549865 TMEM160 -1.06 -14.24 -0.62 3.54e-36 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; CRC cis rs12908161 1.000 rs12910012 chr15:85298662 T/C cg17507749 chr15:85114479 UBE2QP1 0.62 8.97 0.44 2.36e-17 Schizophrenia; CRC cis rs7666738 0.830 rs9998803 chr4:99002519 C/T cg17366294 chr4:99064904 C4orf37 0.44 7.39 0.38 1.19e-12 Colonoscopy-negative controls vs population controls; CRC cis rs8170 0.603 rs971693 chr19:17422649 G/C cg04749549 chr19:17459798 NA -0.45 -7.67 -0.39 1.94e-13 Breast cancer (estrogen-receptor negative);Breast Cancer in BRCA1 mutation carriers;Ovarian cancer;Breast cancer;Epithelial ovarian cancer; CRC cis rs58688157 0.705 rs36060383 chr11:598723 A/C cg09218773 chr11:619014 MUPCDH -0.44 -6.38 -0.33 5.9e-10 Systemic lupus erythematosus; CRC cis rs3857067 0.839 rs12505694 chr4:95042940 T/G cg11021082 chr4:95130006 SMARCAD1 -0.38 -5.75 -0.3 2.07e-8 QT interval; CRC cis rs9527 0.590 rs12785223 chr10:104844011 C/T cg04362960 chr10:104952993 NT5C2 -0.59 -8.26 -0.41 3.64e-15 Arsenic metabolism; CRC cis rs6479527 0.840 rs4744310 chr9:96821508 A/G cg14459158 chr9:96720562 NA 0.38 6.71 0.35 8.37e-11 Esophageal adenocarcinoma; CRC cis rs4689388 0.853 rs1079214 chr4:6282157 T/C cg25554036 chr4:6271136 WFS1 0.54 8.69 0.43 1.68e-16 Type 2 diabetes and other traits;Type 2 diabetes; CRC cis rs2898681 0.519 rs7670068 chr4:53733984 T/G cg00338735 chr4:53728038 RASL11B 0.45 5.94 0.31 7.44e-9 Optic nerve measurement (cup area); CRC cis rs2073300 0.609 rs34648279 chr20:23402935 T/G cg12062639 chr20:23401060 NAPB 0.84 7.64 0.39 2.34e-13 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs9549328 0.565 rs35988856 chr13:113617427 T/C cg08614441 chr13:113633676 MCF2L 0.4 7.06 0.36 9.78e-12 Systolic blood pressure; CRC cis rs62064224 0.553 rs9896320 chr17:30689814 G/A cg21839984 chr17:30846986 MYO1D -0.35 -6.04 -0.32 4.12e-9 Schizophrenia; CRC cis rs4731207 0.596 rs10081375 chr7:124573175 A/G cg23710748 chr7:124431027 NA -0.39 -6.18 -0.32 1.91e-9 Cutaneous malignant melanoma; CRC cis rs10779751 0.887 rs6686835 chr1:11305316 G/A cg08854313 chr1:11322531 MTOR 0.7 10.08 0.49 5.44e-21 Body mass index; CRC trans rs747782 0.528 rs16905753 chr11:48285906 C/T cg15704280 chr7:45808275 SEPT13 0.69 6.97 0.36 1.75e-11 Intraocular pressure; CRC cis rs2304069 1.000 rs10072275 chr5:149401596 T/C cg22760475 chr5:149380129 HMGXB3;TIGD6 0.87 10.04 0.48 7.45e-21 HIV-1 control; CRC cis rs910316 0.967 rs1071989 chr14:75564659 G/T cg11812906 chr14:75593930 NEK9 0.61 9.64 0.47 1.5700000000000001e-19 Height; CRC cis rs926938 0.618 rs360624 chr1:115409476 A/C cg12756093 chr1:115239321 AMPD1 0.57 8.7 0.43 1.58e-16 Autism; CRC trans rs4650994 0.544 rs4075631 chr1:178506594 C/A cg27649806 chr9:35101217 STOML2 0.39 6.2 0.32 1.74e-9 HDL cholesterol levels;HDL cholesterol; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg24157364 chr6:143858286 NA 0.44 5.97 0.31 6.3e-9 Anxiety disorder; CRC cis rs7666738 0.830 rs12233741 chr4:98950296 C/T cg05340658 chr4:99064831 C4orf37 0.61 9.54 0.47 3.45e-19 Colonoscopy-negative controls vs population controls; CRC cis rs8031584 0.958 rs11637469 chr15:31238783 T/C cg08704250 chr15:31115839 NA -0.44 -7.96 -0.4 2.86e-14 Huntington's disease progression; CRC trans rs1455244 0.700 rs7229302 chr18:11508904 G/T cg20607318 chr19:36391512 NFKBID 0.44 6.7 0.35 9.2e-11 Schizophrenia; CRC trans rs1814175 0.645 rs10128563 chr11:50023681 T/C cg11707556 chr5:10655725 ANKRD33B -0.52 -10.25 -0.49 1.36e-21 Height; CRC cis rs10504229 0.906 rs113857287 chr8:58191683 T/C cg05313129 chr8:58192883 C8orf71 -0.46 -6.71 -0.35 8.67e-11 Developmental language disorder (linguistic errors); CRC cis rs7927771 0.929 rs12787646 chr11:47669665 T/C cg20307385 chr11:47447363 PSMC3 -0.52 -7.25 -0.37 3.05e-12 Subjective well-being; CRC cis rs780096 0.527 rs59644396 chr2:27646083 A/G cg21248554 chr2:27665150 KRTCAP3 -0.34 -7.93 -0.4 3.39e-14 Total body bone mineral density; CRC cis rs8072100 0.688 rs8079142 chr17:45442049 G/A cg25173405 chr17:45401733 C17orf57 -0.46 -7.07 -0.36 9.29e-12 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs7589728 1.000 rs11893832 chr2:88507537 G/C cg24977027 chr2:88469347 THNSL2 0.52 5.94 0.31 7.21e-9 Plasma clusterin levels; CRC cis rs9868809 0.772 rs12107252 chr3:48691316 T/C cg00383909 chr3:49044727 WDR6 0.67 7.3 0.37 2.15e-12 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; CRC cis rs7945705 0.905 rs2568054 chr11:8876029 A/G cg00186954 chr11:8933980 ST5;C11orf17 -0.45 -7.18 -0.37 4.79e-12 Hemoglobin concentration; CRC cis rs7618915 0.571 rs6798246 chr3:52599922 G/A cg08222913 chr3:52553049 STAB1 -0.34 -6.27 -0.33 1.14e-9 Bipolar disorder; CRC cis rs11098499 0.644 rs10050092 chr4:120532085 T/C cg24375607 chr4:120327624 NA 0.48 7.59 0.39 3.26e-13 Corneal astigmatism; CRC cis rs6840360 0.607 rs2724565 chr4:152350305 A/G cg09659197 chr4:152720779 NA 0.34 6.66 0.34 1.14e-10 Intelligence (multi-trait analysis); CRC cis rs4141404 0.740 rs4820946 chr22:31551160 A/G cg22777020 chr22:31556080 RNF185 0.48 5.84 0.31 1.26e-8 Paclitaxel-induced neuropathy; CRC cis rs9381040 0.655 rs6939989 chr6:41020205 A/G cg09580153 chr6:41068724 NFYA;LOC221442 -0.4 -5.91 -0.31 8.57e-9 Alzheimer's disease (late onset); CRC cis rs10870270 0.956 rs10870293 chr10:133771413 G/A cg08754478 chr10:133766260 PPP2R2D -0.65 -9.0 -0.44 1.88e-17 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; CRC cis rs13108904 0.870 rs12506095 chr4:1262233 T/C cg16405210 chr4:1374714 KIAA1530 -0.43 -5.88 -0.31 1.01e-8 Obesity-related traits; CRC cis rs2011503 1.000 rs11670687 chr19:19621752 A/G cg11584989 chr19:19387371 SF4 0.57 6.39 0.33 5.7e-10 Bipolar disorder; CRC cis rs921968 0.608 rs7598056 chr2:219352511 A/C cg02176678 chr2:219576539 TTLL4 0.48 7.96 0.4 2.84e-14 Mean corpuscular hemoglobin concentration; CRC cis rs769267 0.929 rs2965180 chr19:19491973 T/C cg03709012 chr19:19516395 GATAD2A -0.72 -11.24 -0.53 4.97e-25 Tonsillectomy; CRC cis rs11229555 0.645 rs4367960 chr11:58194961 C/G cg15696309 chr11:58395628 NA -0.82 -10.45 -0.5 2.81e-22 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; CRC cis rs3749237 0.964 rs11714957 chr3:49776178 C/T cg05072774 chr3:49840536 C3orf54 -0.43 -5.62 -0.3 4.12e-8 Resting heart rate; CRC cis rs2985684 0.948 rs2883437 chr14:50031666 A/G cg04989706 chr14:50066350 PPIL5 -0.62 -8.7 -0.43 1.65e-16 Carotid intima media thickness; CRC cis rs9814567 0.806 rs1880375 chr3:134322163 C/A cg06109529 chr3:134205091 CEP63;ANAPC13 -0.68 -10.11 -0.49 4.15e-21 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs12497850 0.931 rs3774628 chr3:48801840 C/T cg07636037 chr3:49044803 WDR6 1.02 17.9 0.7 1.7e-50 Parkinson's disease; CRC cis rs10504229 0.679 rs11783965 chr8:58130510 T/G cg05313129 chr8:58192883 C8orf71 -0.43 -6.07 -0.32 3.47e-9 Developmental language disorder (linguistic errors); CRC cis rs4073416 0.542 rs8019762 chr14:66087178 A/G cg03016385 chr14:66212404 NA -0.45 -6.2 -0.32 1.67e-9 N-glycan levels; CRC cis rs9467711 0.606 rs9393707 chr6:26362486 T/C cg14345882 chr6:26364793 BTN3A2 0.64 5.63 0.3 3.85e-8 Autism spectrum disorder or schizophrenia; CRC cis rs9325144 0.625 rs11534879 chr12:38968165 A/G cg13010199 chr12:38710504 ALG10B -0.4 -5.6 -0.3 4.5e-8 Morning vs. evening chronotype; CRC cis rs2882667 0.861 rs10075541 chr5:138390318 C/T cg04439458 chr5:138467593 SIL1 -0.34 -6.13 -0.32 2.45e-9 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs172166 0.538 rs1150686 chr6:28161271 T/G cg12172441 chr6:28176163 NA 0.45 6.52 0.34 2.58e-10 Cardiac Troponin-T levels; CRC cis rs4665809 1.000 rs4233708 chr2:26291345 C/T cg26119090 chr2:26468346 HADHA;HADHB -0.61 -7.8 -0.4 8.23e-14 Gut microbiome composition (summer); CRC cis rs2228479 0.717 rs17233678 chr16:89809962 T/C cg19635926 chr16:89946313 TCF25 0.66 5.98 0.31 5.71e-9 Skin colour saturation; CRC cis rs654950 0.806 rs2759251 chr1:42041749 C/G cg06885757 chr1:42089581 HIVEP3 -0.51 -8.68 -0.43 1.84e-16 Airway imaging phenotypes; CRC cis rs881375 0.967 rs1930778 chr9:123641369 A/C cg09586646 chr9:123605570 PSMD5;LOC253039 0.49 6.72 0.35 7.82e-11 Rheumatoid arthritis; CRC cis rs75920871 0.528 rs2513097 chr11:116836212 A/G cg01368799 chr11:117014884 PAFAH1B2 -0.4 -5.7 -0.3 2.72e-8 Subjective well-being; CRC cis rs4481887 0.861 rs10888345 chr1:248447533 A/G cg13385794 chr1:248469461 NA 0.39 6.93 0.36 2.28e-11 Common traits (Other); CRC cis rs294883 0.858 rs9347304 chr6:159717629 C/A cg14500486 chr6:159655392 FNDC1 -0.35 -5.81 -0.3 1.5e-8 Coronary artery disease; CRC cis rs7605827 0.897 rs6431694 chr2:15523031 T/C cg19274914 chr2:15703543 NA 0.38 5.63 0.3 3.81e-8 Educational attainment (years of education); CRC cis rs9325144 0.534 rs4882283 chr12:38710249 C/T cg26384229 chr12:38710491 ALG10B 0.53 7.75 0.39 1.15e-13 Morning vs. evening chronotype; CRC cis rs13144136 0.664 rs4296670 chr4:10651160 C/T cg10242279 chr4:10666415 CLNK -0.35 -5.93 -0.31 7.65e-9 Resistance to antihypertensive treatment in hypertension; CRC cis rs875971 0.929 rs12535036 chr7:65964063 G/T cg11764359 chr7:65958608 NA 0.63 10.25 0.49 1.39e-21 Aortic root size; CRC trans rs12478296 0.685 rs35577962 chr2:242993575 A/G cg06834434 chr14:75079333 LTBP2 0.53 5.98 0.31 5.95e-9 Obesity-related traits; CRC cis rs28386778 0.897 rs8077013 chr17:61850392 C/T cg23090583 chr17:61904693 PSMC5;FTSJ3 1.05 20.23 0.74 1.07e-59 Prudent dietary pattern; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg06583696 chr2:26101536 ASXL2 0.52 6.86 0.35 3.37e-11 Thyroid stimulating hormone; CRC cis rs10479542 0.784 rs6601050 chr5:178986261 C/G cg26516362 chr5:178986906 RUFY1 -0.39 -7.26 -0.37 2.84e-12 Lung cancer; CRC cis rs889312 0.500 rs832585 chr5:56125904 T/C cg24531977 chr5:56204891 C5orf35 -0.45 -6.87 -0.35 3.18e-11 Breast cancer;Breast cancer (early onset); CRC cis rs7618501 0.902 rs7645061 chr3:49868842 C/T cg24308560 chr3:49941425 MST1R -0.45 -7.12 -0.37 6.61e-12 Intelligence (multi-trait analysis); CRC cis rs7618501 0.573 rs2624824 chr3:50088266 T/C cg05623727 chr3:50126028 RBM5 -0.45 -7.61 -0.39 2.93e-13 Intelligence (multi-trait analysis); CRC cis rs7940866 0.838 rs10736592 chr11:130800572 C/T cg12179176 chr11:130786555 SNX19 0.62 8.96 0.44 2.43e-17 Schizophrenia; CRC trans rs587242 1.000 rs2011694 chr1:96884286 T/A cg10631902 chr5:14652156 NA 0.45 7.01 0.36 1.33e-11 Body mass index (joint analysis main effects and physical activity interaction);Body mass index in physically inactive individuals;Body mass index; CRC trans rs9388451 0.839 rs3799709 chr6:126078361 A/G cg05039488 chr6:79577232 IRAK1BP1 -0.57 -8.78 -0.44 8.99e-17 Brugada syndrome; CRC cis rs864537 0.676 rs1773561 chr1:167421951 C/T cg22356347 chr1:167427500 CD247 -0.39 -5.93 -0.31 7.48e-9 Celiac disease or Rheumatoid arthritis;Celiac disease; CRC cis rs11608355 1.000 rs11611370 chr12:109870291 A/G cg19025524 chr12:109796872 NA 0.47 6.83 0.35 4.18e-11 Neuroticism; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg04127825 chr1:167503222 NA 0.48 6.08 0.32 3.26e-9 Thyroid stimulating hormone; CRC cis rs12580194 0.593 rs61957941 chr12:55748058 G/A cg19537932 chr12:55886519 OR6C68 -0.72 -9.1 -0.45 9.11e-18 Cancer; CRC cis rs67311347 1.000 rs6762997 chr3:40478151 C/T cg09455208 chr3:40491958 NA 0.44 8.86 0.44 5.01e-17 Renal cell carcinoma; CRC cis rs9583531 0.689 rs1061386 chr13:111373368 G/C cg24331049 chr13:111365604 ING1 0.55 6.88 0.35 3.1e-11 Coronary artery disease; CRC cis rs2976388 0.556 rs10956985 chr8:143818750 C/A cg24634471 chr8:143751801 JRK -0.51 -6.88 -0.35 3.09e-11 Urinary tract infection frequency; CRC cis rs8077889 0.956 rs6503476 chr17:41850163 C/T cg26893861 chr17:41843967 DUSP3 0.99 14.53 0.63 2.69e-37 Triglycerides; CRC cis rs9486719 0.843 rs3860230 chr6:97036560 T/A cg18709589 chr6:96969512 KIAA0776 -0.46 -5.89 -0.31 9.75e-9 Migraine;Coronary artery disease; CRC cis rs7666738 0.761 rs13136913 chr4:98998031 C/T cg17366294 chr4:99064904 C4orf37 0.44 7.39 0.38 1.19e-12 Colonoscopy-negative controls vs population controls; CRC cis rs11212617 1.000 rs600329 chr11:108163733 A/G cg12106634 chr11:108092400 ATM;NPAT 0.42 6.03 0.32 4.3e-9 Response to metformin in type 2 diabetes (glycemic); CRC cis rs7493 0.901 rs11764079 chr7:95026229 A/G cg07404485 chr7:94953653 PON1 0.41 6.21 0.32 1.59e-9 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs4638749 0.677 rs10185601 chr2:108828278 A/G cg25838818 chr2:108905173 SULT1C2 -0.34 -5.78 -0.3 1.76e-8 Blood pressure; CRC cis rs6088590 0.561 rs11167239 chr20:33140472 G/A cg08999081 chr20:33150536 PIGU 0.63 12.05 0.55 6e-28 Coronary artery disease; CRC cis rs7605378 0.528 rs281791 chr2:200850402 A/G cg23649088 chr2:200775458 C2orf69 -0.7 -11.22 -0.53 6.02e-25 Osteoporosis; CRC cis rs1532331 0.933 rs6451675 chr5:43110855 C/G cg09164108 chr5:43007320 NA 0.38 5.73 0.3 2.33e-8 Menarche (age at onset); CRC cis rs9341808 0.527 rs7453746 chr6:80810013 T/G cg08355045 chr6:80787529 NA 0.4 6.72 0.35 7.82e-11 Sitting height ratio; CRC cis rs12580194 0.593 rs61956269 chr12:55768023 C/T cg23425280 chr12:56401806 NA 0.47 5.74 0.3 2.1e-8 Cancer; CRC cis rs3815700 0.841 rs10410895 chr19:33093655 T/G cg02997394 chr19:33096574 ANKRD27 0.75 8.68 0.43 1.88e-16 Eosinophilic esophagitis; CRC cis rs6951245 1.000 rs11761941 chr7:1097183 G/A cg26224354 chr7:1096374 C7orf50;GPR146 -0.93 -12.05 -0.55 5.9e-28 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC trans rs28735056 0.592 rs2277725 chr18:77694168 A/C cg05926928 chr17:57297772 GDPD1 -0.42 -6.02 -0.31 4.66e-9 Schizophrenia; CRC cis rs1348850 0.914 rs1348849 chr2:178358072 C/T cg22681709 chr2:178499509 PDE11A -0.4 -7.43 -0.38 9.19e-13 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs2708977 0.901 rs6753667 chr2:97160382 G/A cg01950434 chr2:97203154 ARID5A -0.42 -6.33 -0.33 7.87e-10 Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes; CRC cis rs7309 0.935 rs10930013 chr2:162070325 G/A cg21518248 chr2:162101506 NA 0.45 6.64 0.34 1.29e-10 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Educational attainment; CRC cis rs7258465 1.000 rs271623 chr19:18628947 A/G cg06462663 chr19:18546047 ISYNA1 0.52 7.94 0.4 3.13e-14 Breast cancer; CRC cis rs6951245 0.554 rs4724294 chr7:1139695 G/A cg21664854 chr7:1097933 C7orf50;GPR146 0.58 7.34 0.37 1.72e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs2019137 0.539 rs4849177 chr2:113982584 T/C cg12889195 chr2:113992843 PAX8;LOC440839;LOC654433 0.65 10.02 0.48 8.66e-21 Lymphocyte counts; CRC cis rs5753618 0.561 rs2078803 chr22:31652852 G/A cg07713946 chr22:31675144 LIMK2 -0.4 -5.79 -0.3 1.63e-8 Colorectal cancer; CRC cis rs4713118 0.869 rs7773070 chr6:27728827 T/C cg26587870 chr6:27730563 NA -0.42 -6.5 -0.34 3e-10 Parkinson's disease; CRC cis rs3820068 0.581 rs58567918 chr1:15925823 A/G cg13390004 chr1:15929781 NA 0.5 7.09 0.36 8.36e-12 Systolic blood pressure; CRC cis rs7659604 0.539 rs2063165 chr4:122750005 A/G cg20573242 chr4:122745356 CCNA2 0.58 8.74 0.43 1.17e-16 Type 2 diabetes; CRC cis rs9467773 1.000 rs10484442 chr6:26555879 A/G cg09904177 chr6:26538194 HMGN4 0.85 14.85 0.63 1.61e-38 Intelligence (multi-trait analysis); CRC cis rs10870270 1.000 rs11146338 chr10:133770291 C/G cg17892150 chr10:133769511 PPP2R2D -0.74 -10.97 -0.52 4.45e-24 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; CRC cis rs3018066 0.748 rs12509640 chr4:106996677 A/G cg01869342 chr4:106983673 TBCK -0.47 -6.99 -0.36 1.54e-11 Cancer; CRC cis rs12291225 0.545 rs11023187 chr11:14345559 T/G cg19336497 chr11:14380999 RRAS2 -0.52 -9.14 -0.45 6.61e-18 Sense of smell; CRC cis rs9487051 0.700 rs7773815 chr6:109602343 A/C cg01475377 chr6:109611718 NA -0.39 -6.87 -0.35 3.13e-11 Reticulocyte fraction of red cells; CRC cis rs4474465 0.850 rs4944205 chr11:78227790 T/A cg02023728 chr11:77925099 USP35 -0.35 -5.73 -0.3 2.28e-8 Alzheimer's disease (survival time); CRC cis rs12594515 1.000 rs8032835 chr15:45997897 C/G cg01629716 chr15:45996671 NA 0.41 8.35 0.42 1.94e-15 Waist circumference;Weight; CRC trans rs11654801 0.947 rs62056771 chr17:20900570 C/T cg23759823 chr7:139672531 TBXAS1 -0.48 -6.76 -0.35 6.16e-11 Mosquito bite size; CRC cis rs28735056 0.933 rs499472 chr18:77589759 C/T cg20368463 chr18:77673604 PQLC1 -0.54 -8.44 -0.42 9.91e-16 Schizophrenia; CRC cis rs611744 0.647 rs628206 chr8:109247873 A/G cg18478394 chr8:109455254 TTC35 0.37 5.78 0.3 1.75e-8 Dupuytren's disease; CRC cis rs1552244 0.572 rs6783705 chr3:10164783 A/G cg08888203 chr3:10149979 C3orf24 0.71 8.57 0.43 4.18e-16 Alzheimer's disease; CRC cis rs2292884 0.505 rs78063959 chr2:238428961 G/A cg08992911 chr2:238395768 MLPH 0.52 5.69 0.3 2.77e-8 Prostate cancer; CRC cis rs4363385 0.776 rs2879490 chr1:152947163 A/G cg25856811 chr1:152973957 SPRR3 -0.22 -6.08 -0.32 3.38e-9 Inflammatory skin disease; CRC cis rs597539 0.652 rs513615 chr11:68705504 G/T cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.87 14.42 0.62 7.16e-37 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs9393692 0.905 rs7769028 chr6:26267568 C/T cg00631329 chr6:26305371 NA -0.68 -13.16 -0.59 4.41e-32 Educational attainment; CRC cis rs6502050 0.835 rs66531647 chr17:80089022 G/T cg02741985 chr17:80059408 CCDC57 0.43 7.13 0.37 6.48e-12 Life satisfaction; CRC cis rs2762353 0.595 rs12200838 chr6:25753603 C/T cg12310025 chr6:25882481 NA 0.73 10.39 0.5 4.53e-22 Blood metabolite levels; CRC cis rs72634258 0.796 rs4369247 chr1:8168993 C/T cg26816564 chr1:7831052 VAMP3 -0.48 -5.87 -0.31 1.06e-8 Inflammatory bowel disease; CRC cis rs2976388 1.000 rs1045547 chr8:143763757 T/G cg24046110 chr8:143859143 LYNX1 -0.37 -6.37 -0.33 6.29e-10 Urinary tract infection frequency; CRC cis rs12926788 0.542 rs11862971 chr16:24767574 C/A cg06505273 chr16:24850292 NA 0.52 6.74 0.35 7.17e-11 Ejection fraction in Tripanosoma cruzi seropositivity; CRC cis rs13256369 1.000 rs13267501 chr8:8574058 G/A cg18904891 chr8:8559673 CLDN23 0.51 6.99 0.36 1.58e-11 Obesity-related traits; CRC cis rs2836974 0.568 rs4816620 chr21:40613786 A/G cg17971929 chr21:40555470 PSMG1 -0.73 -11.38 -0.53 1.56e-25 Cognitive function; CRC cis rs9303401 0.659 rs62083362 chr17:56846464 A/G cg10487724 chr17:56770010 TEX14;RAD51C 0.77 9.54 0.47 3.4e-19 Cognitive test performance; CRC cis rs7727544 0.636 rs2631365 chr5:131705949 T/C cg11843238 chr5:131593191 PDLIM4 -0.32 -5.93 -0.31 7.63e-9 Blood metabolite levels; CRC cis rs1862618 0.715 rs6866779 chr5:56090000 G/A cg24531977 chr5:56204891 C5orf35 -0.84 -11.21 -0.53 6.45e-25 Initial pursuit acceleration; CRC cis rs2456568 0.867 rs1395384 chr11:93663250 C/T cg26875233 chr11:93583750 C11orf90 0.35 6.84 0.35 3.78e-11 Response to serotonin reuptake inhibitors in major depressive disorder; CRC cis rs13082711 0.834 rs2840088 chr3:27428371 G/A cg02860705 chr3:27208620 NA 0.62 8.83 0.44 6.36e-17 Systolic blood pressure;Diastolic blood pressure;Blood pressure; CRC cis rs2635047 0.638 rs16954999 chr18:44610718 T/C cg19077165 chr18:44547161 KATNAL2 -0.42 -6.28 -0.33 1.09e-9 Educational attainment; CRC cis rs10504229 0.683 rs11786043 chr8:58133174 T/C cg24829409 chr8:58192753 C8orf71 -0.55 -8.03 -0.4 1.71e-14 Developmental language disorder (linguistic errors); CRC cis rs1832871 0.711 rs9459954 chr6:158709345 G/T cg07165851 chr6:158734300 TULP4 0.62 7.76 0.39 1.09e-13 Height; CRC cis rs875971 0.522 rs4718286 chr7:65292764 A/G cg02869306 chr7:64672164 INTS4L1 -0.34 -5.8 -0.3 1.59e-8 Aortic root size; CRC trans rs6703335 0.870 rs10803142 chr1:243598234 A/G cg22852276 chr20:35724169 RBL1 0.44 6.3 0.33 9.53e-10 Schizophrenia;Schizophrenia, schizoaffective disorder or bipolar disorder; CRC cis rs2179367 0.959 rs562428 chr6:149647525 T/C cg07828024 chr6:149772892 ZC3H12D -0.38 -6.02 -0.31 4.76e-9 Dupuytren's disease; CRC cis rs10540 1.000 rs35068485 chr11:466032 A/T cg15790184 chr11:494944 RNH1 0.59 6.1 0.32 2.95e-9 Body mass index; CRC cis rs4665809 1.000 rs4665816 chr2:26305094 G/C cg26119090 chr2:26468346 HADHA;HADHB -0.6 -7.92 -0.4 3.79e-14 Gut microbiome composition (summer); CRC cis rs2932538 0.922 rs12739994 chr1:113131159 T/C cg22162597 chr1:113214053 CAPZA1 0.68 8.79 0.44 8.37e-17 Systolic blood pressure;Diastolic blood pressure;Hypertension;Blood pressure; CRC trans rs492478 0.892 rs115598598 chr5:3908442 C/G cg09199442 chr11:28132951 METT5D1 -0.72 -6.15 -0.32 2.26e-9 Cognitive performance; CRC cis rs2629540 0.847 rs12762597 chr10:126387043 G/A cg08799069 chr10:126477246 METTL10 0.61 7.7 0.39 1.63e-13 Cocaine dependence; CRC cis rs28386778 0.863 rs6504178 chr17:61812733 A/G cg06873352 chr17:61820015 STRADA -0.75 -13.72 -0.6 3.47e-34 Prudent dietary pattern; CRC cis rs7843479 0.562 rs2127206 chr8:21786989 C/T cg16476235 chr8:21771668 DOK2 0.37 6.02 0.32 4.6e-9 Mean corpuscular volume; CRC trans rs288342 0.541 rs10931041 chr2:183685562 A/G cg05308643 chr6:124982296 NKAIN2 0.35 5.99 0.31 5.39e-9 Recurrent major depressive disorder; CRC cis rs6951245 1.000 rs78523927 chr7:1089458 T/C cg03188948 chr7:1209495 NA 0.64 6.46 0.34 3.71e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs10911251 0.528 rs2093982 chr1:183094191 T/C ch.1.3577855R chr1:183094577 LAMC1 0.89 15.86 0.66 1.84e-42 Colorectal cancer; CRC cis rs561341 0.941 rs4525554 chr17:30312819 T/C cg12193833 chr17:30244370 NA -0.75 -8.8 -0.44 7.92e-17 Hip circumference adjusted for BMI; CRC cis rs7615952 0.641 rs12488180 chr3:125782236 C/T cg05084668 chr3:125655381 ALG1L -0.45 -6.5 -0.34 2.96e-10 Blood pressure (smoking interaction); CRC cis rs6952808 1.000 rs6954673 chr7:1886937 C/T cg02951883 chr7:2050386 MAD1L1 -0.72 -11.39 -0.53 1.52e-25 Bipolar disorder and schizophrenia; CRC cis rs172166 0.694 rs9295760 chr6:28147385 G/A cg23161317 chr6:28129485 ZNF389 0.46 6.45 0.33 4.05e-10 Cardiac Troponin-T levels; CRC cis rs6460942 0.915 rs62448596 chr7:12446869 C/T cg06484146 chr7:12443880 VWDE -0.8 -8.59 -0.43 3.55e-16 Coronary artery disease; CRC cis rs67340775 0.541 rs200973 chr6:27858421 A/G cg26587870 chr6:27730563 NA -0.53 -6.25 -0.33 1.24e-9 Lung cancer in ever smokers; CRC cis rs6461049 0.800 rs3800909 chr7:2159594 C/G cg21782813 chr7:2030301 MAD1L1 0.47 8.55 0.43 4.73e-16 Schizophrenia; CRC cis rs2019137 0.560 rs6707386 chr2:113981022 G/A cg19083407 chr2:113993142 PAX8;LOC440839;LOC654433 0.61 8.89 0.44 4.21e-17 Lymphocyte counts; CRC cis rs67340775 0.541 rs200965 chr6:27866384 G/A cg15786705 chr6:28176104 NA 0.59 5.91 0.31 8.44e-9 Lung cancer in ever smokers; CRC cis rs875971 0.862 rs1860469 chr7:66106875 A/G cg18252515 chr7:66147081 NA 0.42 6.01 0.31 5.04e-9 Aortic root size; CRC cis rs11212617 0.840 rs228599 chr11:108107660 G/A cg12106634 chr11:108092400 ATM;NPAT 0.39 5.65 0.3 3.53e-8 Response to metformin in type 2 diabetes (glycemic); CRC cis rs8060686 0.858 rs13334918 chr16:67901343 A/G cg00318322 chr16:67708822 GFOD2 -0.31 -5.99 -0.31 5.54e-9 HDL cholesterol;Metabolic syndrome; CRC cis rs1448094 0.765 rs4919773 chr12:86337559 C/T cg18827107 chr12:86230957 RASSF9 -0.43 -6.83 -0.35 4.16e-11 Major depressive disorder; CRC cis rs10065203 0.527 rs173948 chr5:14347771 A/G cg26689441 chr5:14406021 TRIO -0.39 -6.45 -0.33 4.09e-10 Paclitaxel-induced neuropathy; CRC cis rs7103648 0.669 rs7131262 chr11:47836302 T/A cg20307385 chr11:47447363 PSMC3 0.75 10.29 0.49 1e-21 Diastolic blood pressure;Systolic blood pressure; CRC cis rs7615952 0.599 rs16834938 chr3:125706046 C/T cg15145296 chr3:125709740 NA -0.53 -6.42 -0.33 4.69e-10 Blood pressure (smoking interaction); CRC cis rs2415984 0.622 rs1761026 chr14:46930139 T/C cg14871534 chr14:47121158 RPL10L 0.41 5.93 0.31 7.52e-9 Number of children ever born; CRC trans rs877282 0.628 rs11253435 chr10:824169 T/C cg22713356 chr15:30763199 NA 0.79 9.0 0.44 1.83e-17 Uric acid levels; CRC cis rs7224685 0.569 rs8082483 chr17:4000849 G/A cg09597638 chr17:3907349 NA 0.44 5.66 0.3 3.27e-8 Type 2 diabetes; CRC cis rs9733 0.596 rs34140753 chr1:150642583 T/C cg10589385 chr1:150898437 SETDB1 0.28 5.98 0.31 5.86e-9 Tonsillectomy; CRC trans rs13315871 0.615 rs7618604 chr3:58357785 G/A cg25250853 chr2:85822726 RNF181 0.53 6.25 0.33 1.28e-9 Cholesterol, total; CRC cis rs2032447 0.530 rs9356996 chr6:26008487 C/A cg18357526 chr6:26021779 HIST1H4A 0.65 10.02 0.48 8.17e-21 Intelligence (multi-trait analysis); CRC cis rs1552244 0.572 rs59074548 chr3:10164347 G/C cg10729496 chr3:10149963 C3orf24 0.48 5.61 0.3 4.19e-8 Alzheimer's disease; CRC cis rs875971 0.830 rs587360 chr7:65522698 C/A cg12463550 chr7:65579703 CRCP 0.46 6.57 0.34 2e-10 Aortic root size; CRC cis rs4237845 0.788 rs6581157 chr12:58288793 C/T cg02175503 chr12:58329896 NA 0.53 6.74 0.35 7.32e-11 Intelligence (multi-trait analysis); CRC cis rs10791323 0.536 rs1944731 chr11:133726067 G/A cg06766960 chr11:133703094 NA -0.38 -6.2 -0.32 1.67e-9 Childhood ear infection; CRC cis rs11122272 0.735 rs2808584 chr1:231512925 A/G cg06096015 chr1:231504339 EGLN1 0.4 5.95 0.31 6.7e-9 Hemoglobin concentration; CRC cis rs2404602 0.692 rs58973160 chr15:77000342 T/C cg23625390 chr15:77176239 SCAPER 0.49 7.07 0.36 9.37e-12 Blood metabolite levels; CRC cis rs2739330 0.760 rs5751760 chr22:24243573 G/A cg16132339 chr22:24313637 DDTL;DDT 0.59 9.27 0.46 2.48e-18 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs6500602 0.701 rs8129 chr16:4562351 A/G cg14951292 chr16:4525986 HMOX2;NMRAL1 0.61 8.62 0.43 2.96e-16 Schizophrenia; CRC cis rs12586317 0.548 rs12590678 chr14:35602956 C/T cg05294307 chr14:35346193 BAZ1A -0.67 -7.26 -0.37 2.79e-12 Psoriasis; CRC cis rs1218582 0.682 rs12046459 chr1:154912017 A/C cg09359103 chr1:154839909 KCNN3 -0.72 -12.33 -0.56 5.82e-29 Prostate cancer; CRC cis rs10751667 0.600 rs10794342 chr11:924904 C/T ch.11.42038R chr11:967971 AP2A2 0.6 10.24 0.49 1.56e-21 Alzheimer's disease (late onset); CRC cis rs1707322 0.717 rs1135812 chr1:46095272 T/C cg03146154 chr1:46216737 IPP 0.66 9.6 0.47 2.07e-19 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC trans rs9858542 1.000 rs9858542 chr3:49701983 A/G cg21582582 chr3:182698605 DCUN1D1 0.55 6.66 0.34 1.13e-10 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs11229555 0.609 rs7128459 chr11:58179291 C/T cg15696309 chr11:58395628 NA -0.81 -10.31 -0.49 8.83e-22 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; CRC cis rs11098499 0.863 rs11731756 chr4:120478696 T/G cg24375607 chr4:120327624 NA 0.48 7.24 0.37 3.2e-12 Corneal astigmatism; CRC cis rs780094 0.585 rs3739095 chr2:27556721 C/T cg21248554 chr2:27665150 KRTCAP3 -0.26 -5.99 -0.31 5.52e-9 Calcium levels;Fasting blood insulin;Metabolic traits;Triglyceride levels;Fasting plasma glucose;Urate levels in overweight individuals;Urate levels in obese individuals;Uric acid levels;Height;Age-related diseases, mortality and associated endophenotypes;Renal underexcretion gout;Fasting blood glucose (BMI interaction);Urate levels;Gondoic acid (20:1n-9) levels;Fasting blood insulin (BMI interaction);Triglycerides;Plasma omega-3 polyunsaturated fatty acid levels (docosapentaenoic acid);Type 2 diabetes;Nonalcoholic fatty liver disease;Hypertriglyceridemia;C-reactive protein;Age-related disease endophenotypes;LDL cholesterol;Metabolic syndrome;Crohn's disease;Alcohol consumption (drinks per week);Homeostasis model assessment of insulin resistance;Alcohol consumption;Red blood cell count;Fasting blood glucose; CRC cis rs514406 0.825 rs497535 chr1:53284677 A/G cg24675658 chr1:53192096 ZYG11B 0.56 8.11 0.41 1.04e-14 Monocyte count; CRC cis rs9322193 0.962 rs6903998 chr6:150152493 T/C cg04369109 chr6:150039330 LATS1 -0.42 -5.69 -0.3 2.75e-8 Lung cancer; CRC trans rs853679 0.607 rs200489 chr6:27798257 T/C cg16898833 chr6:26189333 HIST1H4D 0.72 6.47 0.34 3.61e-10 Depression; CRC cis rs1448094 0.556 rs17279916 chr12:86170647 G/A cg00310523 chr12:86230176 RASSF9 0.42 6.8 0.35 4.86e-11 Major depressive disorder; CRC cis rs2243480 1.000 rs34529418 chr7:65403209 A/G cg18252515 chr7:66147081 NA -1.08 -12.66 -0.57 3.44e-30 Diabetic kidney disease; CRC cis rs11628318 0.614 rs11847932 chr14:103185435 T/G cg23071808 chr14:103021642 NA 0.61 6.79 0.35 5.2e-11 Platelet count; CRC cis rs1223397 1.000 rs1223402 chr6:13271640 G/A cg06879394 chr6:13274151 PHACTR1 0.54 6.52 0.34 2.66e-10 Blood pressure; CRC cis rs9595066 1.000 rs4942281 chr13:44708126 C/T cg04068111 chr13:44716778 NA -0.47 -6.0 -0.31 5.16e-9 Schizophrenia; CRC cis rs1127311 0.875 rs9427102 chr1:154586957 A/G cg17218026 chr1:154582156 ADAR 0.67 11.39 0.53 1.49e-25 C-reactive protein levels or triglyceride levels (pleiotropy); CRC cis rs6696846 0.765 rs11576867 chr1:205064676 C/T cg00857998 chr1:205179979 DSTYK 0.44 6.11 0.32 2.8e-9 Red blood cell count; CRC cis rs6951245 1.000 rs74785791 chr7:1088494 T/C cg18402987 chr7:1209562 NA 0.64 6.67 0.35 1.05e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs1552244 1.000 rs7652935 chr3:10151138 T/C cg13047869 chr3:10149882 C3orf24 0.57 7.73 0.39 1.34e-13 Alzheimer's disease; CRC cis rs432925 0.600 rs214249 chr16:348687 T/G cg06233593 chr16:337645 AXIN1 0.59 9.08 0.45 9.93e-18 Morning vs. evening chronotype; CRC cis rs57221529 0.664 rs72704802 chr5:554211 C/T cg16447950 chr5:562315 NA -0.84 -11.04 -0.52 2.51e-24 Lung disease severity in cystic fibrosis; CRC cis rs9488822 0.676 rs12190737 chr6:116328128 C/A cg26893134 chr6:116381904 FRK 0.26 7.61 0.39 2.98e-13 Cholesterol, total;LDL cholesterol; CRC cis rs7953508 0.711 rs3825198 chr12:93977465 T/A cg18151635 chr12:93972918 NA -0.7 -9.58 -0.47 2.42e-19 Pubertal anthropometrics; CRC cis rs10504229 0.683 rs7843919 chr8:58130792 T/C cg04204079 chr8:58130323 NA -0.45 -5.78 -0.3 1.71e-8 Developmental language disorder (linguistic errors); CRC cis rs17021463 0.902 rs62320439 chr4:95248721 G/C cg11021082 chr4:95130006 SMARCAD1 0.47 6.9 0.36 2.71e-11 Testicular germ cell tumor; CRC cis rs1008375 0.618 rs13129002 chr4:17567513 A/G cg16339924 chr4:17578868 LAP3 0.55 7.0 0.36 1.43e-11 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs7208859 0.623 rs9906957 chr17:29157755 C/T cg13385521 chr17:29058706 SUZ12P 0.69 8.16 0.41 7.14e-15 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs698833 0.926 rs1085485 chr2:44616728 A/G cg04920474 chr2:44395004 PPM1B 0.4 5.82 0.31 1.39e-8 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; CRC cis rs4689388 0.750 rs10755148 chr4:6295064 A/G cg25554036 chr4:6271136 WFS1 0.46 6.97 0.36 1.7e-11 Type 2 diabetes and other traits;Type 2 diabetes; CRC cis rs875971 0.540 rs736270 chr7:65428822 T/C cg18876405 chr7:65276391 NA 0.62 10.75 0.51 2.56e-23 Aortic root size; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg06062132 chr6:76311331 SENP6 0.43 5.98 0.31 5.77e-9 Response to antipsychotic treatment; CRC cis rs4664293 0.836 rs13403371 chr2:160593114 G/A cg08347373 chr2:160653686 CD302 -0.47 -7.43 -0.38 9.32e-13 Monocyte percentage of white cells; CRC cis rs17270561 0.578 rs76182885 chr6:25904085 G/C cg16482183 chr6:26056742 HIST1H1C 1.01 12.13 0.56 3.11e-28 Iron status biomarkers; CRC trans rs4942242 0.640 rs9533563 chr13:44212127 A/G cg19169023 chr15:41853346 TYRO3 -0.6 -8.48 -0.42 7.52e-16 Response to tocilizumab in rheumatoid arthritis; CRC cis rs7589728 0.514 rs74426843 chr2:88459388 C/T cg24977027 chr2:88469347 THNSL2 0.64 7.72 0.39 1.37e-13 Plasma clusterin levels; CRC cis rs478304 0.593 rs2236682 chr11:65480090 G/T cg05805236 chr11:65401703 PCNXL3 -0.4 -6.33 -0.33 7.94e-10 Acne (severe); CRC trans rs62295889 0.602 rs58099533 chr4:12538214 G/T cg03490839 chr16:73082051 ZFHX3 0.58 6.06 0.32 3.82e-9 Obesity-related traits; CRC trans rs7267979 1.000 rs6050547 chr20:25326012 C/T cg17903999 chr18:56338584 MALT1 0.42 6.88 0.35 2.95e-11 Liver enzyme levels (alkaline phosphatase); CRC cis rs11155671 0.530 rs6557133 chr6:150195384 G/T cg13206674 chr6:150067644 NUP43 0.5 7.05 0.36 1.09e-11 Testicular germ cell tumor; CRC cis rs1552244 1.000 rs67006488 chr3:10152993 T/C cg10729496 chr3:10149963 C3orf24 0.55 7.08 0.36 8.63e-12 Alzheimer's disease; CRC trans rs1656966 1.000 rs1656966 chr3:186466252 C/T cg14593956 chr5:138677986 PAIP2 0.41 6.3 0.33 9.7e-10 Myopia (pathological); CRC cis rs12541635 0.966 rs4734894 chr8:106995313 G/A cg10147462 chr8:107024639 NA 0.45 7.43 0.38 9.67e-13 Age of smoking initiation; CRC cis rs10504229 0.683 rs2873638 chr8:58114593 G/A cg22535103 chr8:58192502 C8orf71 -0.69 -9.23 -0.45 3.37e-18 Developmental language disorder (linguistic errors); CRC cis rs11098499 0.754 rs1511025 chr4:120240238 T/C cg24375607 chr4:120327624 NA 0.48 7.64 0.39 2.32e-13 Corneal astigmatism; CRC cis rs7799006 0.527 rs2159045 chr7:2207401 T/C cg08027265 chr7:2291960 NA -0.38 -5.97 -0.31 6.08e-9 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs3858526 0.883 rs4758183 chr11:5925178 C/G cg13902645 chr11:5959945 NA -0.6 -8.26 -0.41 3.66e-15 DNA methylation (variation); CRC cis rs35110281 0.811 rs2838337 chr21:45072621 A/C cg01579765 chr21:45077557 HSF2BP -0.41 -7.9 -0.4 4.31e-14 Mean corpuscular volume; CRC cis rs6534441 0.824 rs28548600 chr4:125458268 A/C cg21609808 chr4:125404261 NA 0.38 5.75 0.3 2.07e-8 Major depressive disorder; CRC cis rs9916302 0.904 rs2168785 chr17:37407135 C/T cg03013999 chr17:37608204 MED1 0.49 7.54 0.38 4.77e-13 Glomerular filtration rate (creatinine); CRC cis rs3764400 0.506 rs56103412 chr17:46542302 T/A cg10706073 chr17:46328419 SKAP1 -0.58 -5.95 -0.31 6.69e-9 Body mass index; CRC cis rs9372498 0.536 rs17080292 chr6:118850266 A/G cg22561889 chr6:118971681 C6orf204 0.51 6.65 0.34 1.23e-10 Diastolic blood pressure; CRC cis rs12188164 0.543 rs2672757 chr5:454732 A/G cg14122633 chr5:456516 EXOC3 -0.38 -6.71 -0.35 8.32e-11 Cystic fibrosis severity; CRC cis rs35264875 0.796 rs72928657 chr11:68852336 T/C cg01993067 chr11:68851601 TPCN2 0.56 6.3 0.33 9.54e-10 Blond vs. brown hair color; CRC cis rs9818758 0.556 rs11716614 chr3:49017208 C/G cg00383909 chr3:49044727 WDR6 1.36 11.14 0.52 1.1e-24 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; CRC cis rs2188554 0.771 rs213951 chr7:117202434 A/G cg09181792 chr7:117119393 CFTR 0.31 5.69 0.3 2.81e-8 Esophageal adenocarcinoma; CRC cis rs73200209 0.912 rs17498459 chr12:116541595 T/C cg01776926 chr12:116560359 MED13L -0.51 -6.27 -0.33 1.11e-9 Total body bone mineral density; CRC cis rs853679 0.517 rs4713144 chr6:28106790 C/G cg02631126 chr6:28058918 ZSCAN12L1 0.29 5.89 0.31 9.41e-9 Depression; CRC trans rs4927850 1.000 rs7627868 chr3:195753473 A/T cg16724585 chr3:197361211 NA -0.48 -7.08 -0.36 8.94e-12 Pancreatic cancer; CRC cis rs644799 0.710 rs1852535 chr11:95501241 A/G cg25478527 chr11:95522999 CEP57;FAM76B 0.49 7.49 0.38 6.2800000000000005e-13 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs951366 0.789 rs823137 chr1:205738302 C/T cg26354017 chr1:205819088 PM20D1 0.73 11.02 0.52 3.06e-24 Menarche (age at onset); CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg18162120 chr1:224621880 WDR26 -0.39 -6.14 -0.32 2.34e-9 Myopia (pathological); CRC cis rs11098499 0.865 rs11098513 chr4:120316075 A/G cg24375607 chr4:120327624 NA 0.5 7.58 0.39 3.48e-13 Corneal astigmatism; CRC trans rs2243480 1.000 rs3885839 chr7:65290403 G/T cg10756647 chr7:56101905 PSPH 0.7 7.15 0.37 5.55e-12 Diabetic kidney disease; CRC cis rs2019137 0.560 rs4849179 chr2:113985170 C/T cg07594247 chr2:113993304 PAX8;LOC440839;LOC654433 0.48 7.49 0.38 6.55e-13 Lymphocyte counts; CRC cis rs2282802 0.651 rs13353827 chr5:139654537 T/C cg26211634 chr5:139558579 C5orf32 0.43 7.39 0.38 1.26e-12 Intelligence (multi-trait analysis); CRC trans rs9292195 0.641 rs16877156 chr5:58427551 A/T cg27555894 chr19:5799374 NA -0.49 -6.24 -0.33 1.33e-9 Breast cancer; CRC cis rs3733585 0.664 rs17185870 chr4:9958214 C/A cg00071950 chr4:10020882 SLC2A9 -0.54 -9.58 -0.47 2.44e-19 Cleft plate (environmental tobacco smoke interaction); CRC cis rs76878669 0.561 rs10791872 chr11:66138434 C/G cg24851651 chr11:66362959 CCS 0.34 5.64 0.3 3.61e-8 Educational attainment (years of education); CRC cis rs13118159 0.505 rs1250128 chr4:1257311 T/C cg02475777 chr4:1388615 CRIPAK -0.5 -6.24 -0.33 1.32e-9 Longevity; CRC cis rs9837602 0.872 rs4928234 chr3:99704861 T/C cg07805332 chr3:99536008 MIR548G;C3orf26 0.47 6.2 0.32 1.65e-9 Breast cancer; CRC cis rs7666738 0.962 rs17027204 chr4:98997049 G/A cg03676636 chr4:99064102 C4orf37 0.23 6.35 0.33 7.2e-10 Colonoscopy-negative controls vs population controls; CRC cis rs2239547 0.657 rs2071040 chr3:52864860 A/G cg10802521 chr3:52805072 NEK4 -0.46 -6.04 -0.32 4.14e-9 Schizophrenia; CRC cis rs11574514 1.000 rs8051653 chr16:67848515 T/C cg26727032 chr16:67993705 SLC12A4 -0.62 -6.02 -0.31 4.73e-9 Crohn's disease; CRC cis rs6952808 0.689 rs79950306 chr7:2022063 C/G cg02951883 chr7:2050386 MAD1L1 -0.76 -11.96 -0.55 1.27e-27 Bipolar disorder and schizophrenia; CRC cis rs1153858 1.000 rs12441971 chr15:45671957 A/T cg10760299 chr15:45669010 GATM 0.5 7.82 0.4 7.18e-14 Homoarginine levels; CRC cis rs853679 0.517 rs9368557 chr6:28131537 T/C cg06470822 chr6:28175283 NA 1.03 13.59 0.6 1.04e-33 Depression; CRC cis rs9359856 0.518 rs72929359 chr6:90260111 A/G cg13799429 chr6:90582589 CASP8AP2 -0.59 -6.83 -0.35 4.08e-11 Bipolar disorder; CRC cis rs6499255 0.951 rs60099379 chr16:69582104 A/G cg15192750 chr16:69999425 NA 0.59 7.78 0.39 9.62e-14 IgE levels; CRC cis rs4481887 0.646 rs28421649 chr1:248548122 G/C cg26353448 chr1:248524236 OR2T4 -0.29 -6.0 -0.31 5.17e-9 Common traits (Other); CRC cis rs1448094 0.547 rs7954472 chr12:86166258 T/C cg19622623 chr12:86230825 RASSF9 -0.38 -5.8 -0.3 1.53e-8 Major depressive disorder; CRC cis rs891088 0.695 rs10411728 chr19:7194938 C/T cg09779027 chr19:7224513 INSR -0.61 -7.5 -0.38 6.12e-13 Hip circumference adjusted for BMI;Height; CRC cis rs6598955 0.670 rs11247892 chr1:26592727 A/G cg00852783 chr1:26633632 UBXN11 0.43 7.02 0.36 1.25e-11 Obesity-related traits; CRC cis rs743757 1.000 rs743757 chr3:50476378 C/G cg09545109 chr3:50388910 TUSC4;CYB561D2 -0.45 -6.57 -0.34 1.98e-10 Diastolic blood pressure; CRC cis rs7615952 0.599 rs6438953 chr3:125724951 T/C cg02807482 chr3:125708958 NA -0.41 -5.72 -0.3 2.37e-8 Blood pressure (smoking interaction); CRC cis rs10504229 0.861 rs57942497 chr8:58171239 G/T cg02290350 chr8:58132656 NA -0.42 -5.96 -0.31 6.62e-9 Developmental language disorder (linguistic errors); CRC cis rs7777754 0.512 rs3757472 chr7:50537983 A/C cg18232548 chr7:50535776 DDC -0.44 -6.78 -0.35 5.59e-11 Response to zileuton treatment in asthma (FEV1 change interaction); CRC cis rs2229774 1.000 rs2229774 chr12:53605545 A/G cg21746001 chr12:53610772 RARG 0.83 6.27 0.33 1.14e-9 Anthracycline-induced cardiotoxicity in childhood cancer; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg02717486 chr5:133512833 SKP1 0.37 5.97 0.31 6.03e-9 Liver disease severity in Alagille syndrome; CRC trans rs72665486 0.527 rs11729972 chr4:91978448 C/G cg19903196 chr1:212429231 NA 0.42 5.97 0.31 6.1e-9 Multiple myeloma; CRC cis rs6918586 0.636 rs198817 chr6:26126524 A/G cg18357526 chr6:26021779 HIST1H4A -0.49 -7.32 -0.37 1.97e-12 Schizophrenia; CRC cis rs7089973 0.966 rs749649 chr10:116641999 G/A cg23260525 chr10:116636907 FAM160B1 0.33 6.29 0.33 1.02e-9 Bipolar disorder or attention deficit hyperactivity disorder; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg16657816 chr16:30905695 BCL7C 0.47 6.84 0.35 3.97e-11 Anxiety disorder; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg17664265 chr3:186285263 TBCCD1 0.45 6.2 0.32 1.68e-9 Response to antipsychotic treatment; CRC cis rs1862618 0.715 rs6866779 chr5:56090000 G/A cg20203395 chr5:56204925 C5orf35 -0.74 -8.72 -0.43 1.41e-16 Initial pursuit acceleration; CRC cis rs34375054 0.752 rs12582808 chr12:125661459 G/T cg25124228 chr12:125621409 AACS -0.51 -6.29 -0.33 1.02e-9 Post bronchodilator FEV1/FVC ratio; CRC cis rs13108904 0.870 rs2291199 chr4:1244267 A/G cg21620606 chr4:1342894 KIAA1530 0.41 7.01 0.36 1.39e-11 Obesity-related traits; CRC cis rs3733585 0.699 rs6823361 chr4:9963127 A/G cg00071950 chr4:10020882 SLC2A9 -0.55 -9.92 -0.48 1.83e-20 Cleft plate (environmental tobacco smoke interaction); CRC cis rs920590 0.684 rs59565447 chr8:19668430 A/T cg03894339 chr8:19674705 INTS10 0.42 5.77 0.3 1.85e-8 Acute lymphoblastic leukemia (childhood); CRC cis rs1153858 1.000 rs11070457 chr15:45686943 A/C cg10760299 chr15:45669010 GATM 0.51 7.81 0.4 7.79e-14 Homoarginine levels; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg25817788 chr6:21589024 NA 0.46 6.68 0.35 1.02e-10 Response to antipsychotic treatment; CRC cis rs501120 1.000 rs665855 chr10:44757751 T/C cg09554077 chr10:44749378 NA 0.78 12.0 0.55 9.18e-28 Coronary artery disease;Coronary heart disease; CRC cis rs10782582 0.593 rs4638068 chr1:76161663 G/A cg03433033 chr1:76189801 ACADM -0.43 -6.24 -0.33 1.37e-9 Daytime sleep phenotypes; CRC cis rs877282 1.000 rs11253369 chr10:773610 C/G cg17470449 chr10:769945 NA 0.5 7.67 0.39 1.92e-13 Uric acid levels; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg18771857 chr5:138609219 MATR3;SNHG4 0.39 6.01 0.31 4.99e-9 Response to antipsychotic treatment; CRC trans rs3743266 0.613 rs2414669 chr15:60708824 A/G cg12836136 chr22:38245342 EIF3L 0.44 6.82 0.35 4.48e-11 Menarche (age at onset); CRC cis rs6662572 0.737 rs7530480 chr1:46399655 T/C cg08644498 chr1:46502608 NA -0.45 -7.08 -0.36 8.76e-12 Blood protein levels; CRC cis rs25645 0.502 rs9895948 chr17:38108363 T/C cg17344932 chr17:38183730 MED24;SNORD124 -0.56 -8.92 -0.44 3.24e-17 Myeloid white cell count; CRC cis rs9393692 0.905 rs7450556 chr6:26299900 C/T cg05868516 chr6:26286170 HIST1H4H 0.39 5.73 0.3 2.32e-8 Educational attainment; CRC cis rs7524258 0.868 rs1304712 chr1:7270538 C/T cg07173049 chr1:7289937 CAMTA1 0.54 9.12 0.45 7.61e-18 Tourette's syndrome or obsessive-compulsive disorder; CRC trans rs1455244 0.700 rs7229302 chr18:11508904 G/T cg08377010 chr19:48673515 LIG1 0.39 6.12 0.32 2.62e-9 Schizophrenia; CRC cis rs854765 0.964 rs854764 chr17:18011750 A/G cg09796270 chr17:17721594 SREBF1 -0.54 -7.73 -0.39 1.29e-13 Total body bone mineral density; CRC cis rs950169 1.000 rs34751999 chr15:84758419 T/C cg17507749 chr15:85114479 UBE2QP1 0.77 11.92 0.55 1.78e-27 Schizophrenia; CRC trans rs11098499 0.863 rs3822190 chr4:120428098 G/A cg25214090 chr10:38739885 LOC399744 0.63 9.76 0.47 6.33e-20 Corneal astigmatism; CRC cis rs6740322 0.793 rs13414908 chr2:43546658 G/C cg06169590 chr2:43455088 ZFP36L2;LOC100129726 -0.6 -7.25 -0.37 2.92e-12 Coronary artery disease; CRC cis rs11122272 0.735 rs2437147 chr1:231516756 T/C cg06096015 chr1:231504339 EGLN1 0.4 5.94 0.31 7.17e-9 Hemoglobin concentration; CRC cis rs6460942 0.915 rs62447638 chr7:12484667 G/A cg20607287 chr7:12443886 VWDE -0.66 -6.84 -0.35 3.78e-11 Coronary artery disease; CRC cis rs2115536 0.704 rs2163005 chr15:80194480 A/G cg00225070 chr15:80189496 MTHFS 0.49 7.44 0.38 8.57e-13 Eosinophil counts;Eosinophil percentage of white cells;Sum eosinophil basophil counts;Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; CRC cis rs7224685 0.501 rs11652060 chr17:4010412 A/T cg09695851 chr17:3907499 NA -0.79 -14.43 -0.62 6.36e-37 Type 2 diabetes; CRC cis rs4819052 0.851 rs2838842 chr21:46669217 C/T cg02159808 chr21:46707872 POFUT2;LOC642852 0.48 6.4 0.33 5.44e-10 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs1799949 1.000 rs16940 chr17:41245237 A/G cg01879757 chr17:41196368 BRCA1 -0.41 -6.02 -0.32 4.61e-9 Menopause (age at onset); CRC cis rs8063761 0.640 rs4785760 chr16:90051438 G/A cg25193494 chr16:90016004 DEF8 0.51 7.95 0.4 3.02e-14 Squamous cell carcinoma; CRC cis rs7412746 0.611 rs11204747 chr1:150927152 A/G cg17724175 chr1:150552817 MCL1 -0.38 -5.81 -0.3 1.5e-8 Melanoma; CRC cis rs2949837 0.581 rs2949838 chr7:45993924 T/C cg04796162 chr7:45961102 IGFBP3 0.41 7.16 0.37 5.19e-12 Sitting height ratio; CRC cis rs10504229 1.000 rs77823122 chr8:58170161 A/G cg22535103 chr8:58192502 C8orf71 -0.82 -12.27 -0.56 9.63e-29 Developmental language disorder (linguistic errors); CRC cis rs731174 0.921 rs6686264 chr1:38192337 A/T cg06917450 chr1:38156652 C1orf109 -0.46 -6.9 -0.36 2.61e-11 Prostate cancer (SNP x SNP interaction); CRC cis rs6545883 0.831 rs2592356 chr2:61810428 G/C cg15711740 chr2:61764176 XPO1 -0.52 -7.01 -0.36 1.33e-11 Tuberculosis; CRC cis rs60843830 0.964 rs17713879 chr2:254215 G/A cg00108164 chr2:264199 ACP1;SH3YL1 0.62 9.74 0.47 7.52e-20 Spherical equivalent (joint analysis main effects and education interaction); CRC cis rs2576037 0.583 rs530205 chr18:44385150 C/T cg23996704 chr18:44553084 KATNAL2 -0.31 -6.08 -0.32 3.38e-9 Personality dimensions; CRC cis rs6754459 0.603 rs11894441 chr2:3701972 A/G cg00999904 chr2:3704751 ALLC 0.42 5.97 0.31 6e-9 Response to inhaled corticosteroid treatment in asthma (change in FEV1); CRC cis rs933688 1.000 rs4382199 chr5:90744228 A/G cg26981201 chr5:90679533 LOC100129716;ARRDC3 0.98 15.01 0.64 3.59e-39 Smoking behavior; CRC cis rs2857891 1.000 rs2638092 chr11:6961746 G/A cg14883916 chr11:6947541 ZNF215 0.63 6.83 0.35 4.02e-11 Response to cytadine analogues (cytosine arabinoside); CRC cis rs9847710 0.967 rs2564938 chr3:53026384 C/T cg18404041 chr3:52824283 ITIH1 0.3 5.87 0.31 1.04e-8 Ulcerative colitis; CRC trans rs1814175 0.867 rs7926002 chr11:49616018 A/G cg03929089 chr4:120376271 NA -0.93 -16.89 -0.68 1.57e-46 Height; CRC cis rs4664293 0.667 rs10169681 chr2:160638576 G/A cg08347373 chr2:160653686 CD302 0.51 8.71 0.43 1.47e-16 Monocyte percentage of white cells; CRC cis rs7927771 1.000 rs10838757 chr11:47763016 T/C cg18512352 chr11:47633146 NA -0.49 -9.6 -0.47 2.09e-19 Subjective well-being; CRC cis rs6500602 0.627 rs6500610 chr16:4529613 A/G cg14951292 chr16:4525986 HMOX2;NMRAL1 0.72 10.13 0.49 3.73e-21 Schizophrenia; CRC cis rs6804368 0.553 rs1350785 chr3:30753995 A/C cg06106510 chr3:30762233 NA -0.35 -5.72 -0.3 2.44e-8 Blood metabolite levels; CRC cis rs6479527 0.904 rs4744316 chr9:96864456 A/C cg14459158 chr9:96720562 NA -0.39 -6.79 -0.35 5.29e-11 Esophageal adenocarcinoma; CRC cis rs6957923 0.967 rs11773741 chr7:23484232 A/G cg20265043 chr7:23510089 IGF2BP3 0.37 5.74 0.3 2.12e-8 Height; CRC cis rs9611565 0.512 rs5751148 chr22:42139078 A/G cg06481639 chr22:41940642 POLR3H 0.55 6.19 0.32 1.82e-9 Vitiligo; CRC cis rs9322193 0.923 rs1080670 chr6:149941297 C/G cg07701084 chr6:150067640 NUP43 0.55 8.04 0.41 1.58e-14 Lung cancer; CRC trans rs1005277 0.579 rs2474568 chr10:38383147 A/T cg27523141 chr10:43048294 ZNF37B 0.49 7.24 0.37 3.17e-12 Extrinsic epigenetic age acceleration; CRC cis rs7666738 0.830 rs2865981 chr4:99031493 G/A cg05340658 chr4:99064831 C4orf37 0.6 9.26 0.45 2.72e-18 Colonoscopy-negative controls vs population controls; CRC cis rs72634258 0.842 rs4325151 chr1:8168917 T/A cg26816564 chr1:7831052 VAMP3 -0.49 -6.05 -0.32 3.97e-9 Inflammatory bowel disease; CRC cis rs9649213 0.593 rs7787858 chr7:98009914 T/C cg08684580 chr7:98029266 BAIAP2L1 -0.32 -5.71 -0.3 2.56e-8 Prostate cancer (SNP x SNP interaction); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg07816229 chr5:154317915 GEMIN5 0.38 5.97 0.31 6.13e-9 Liver disease severity in Alagille syndrome; CRC trans rs8002861 1.000 rs8002861 chr13:44474517 G/A cg12856521 chr11:46389249 DGKZ 0.38 6.14 0.32 2.41e-9 Leprosy; CRC cis rs6952808 0.723 rs4721295 chr7:2036669 G/T cg18279126 chr7:2041391 MAD1L1 -0.39 -5.88 -0.31 9.89e-9 Bipolar disorder and schizophrenia; CRC cis rs394563 0.726 rs366905 chr6:149735097 T/A cg11245181 chr6:149772854 ZC3H12D -0.53 -9.33 -0.46 1.56e-18 Dupuytren's disease; CRC cis rs10876993 0.826 rs1678534 chr12:58057435 A/C cg18357645 chr12:58087776 OS9 0.56 7.62 0.39 2.7e-13 Celiac disease or Rheumatoid arthritis; CRC cis rs7493 0.755 rs34774523 chr7:94962142 G/A cg19678392 chr7:94953810 PON1 -0.53 -6.76 -0.35 6.2e-11 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs798554 0.797 rs1182183 chr7:2873136 C/T cg13628971 chr7:2884303 GNA12 0.54 7.33 0.37 1.84e-12 Height; CRC cis rs9916302 0.904 rs600010 chr17:37433517 T/C cg00129232 chr17:37814104 STARD3 -0.55 -8.05 -0.41 1.57e-14 Glomerular filtration rate (creatinine); CRC cis rs2019137 0.905 rs2276561 chr2:113956371 G/C cg07772999 chr2:113993052 PAX8;LOC440839;LOC654433 -0.45 -6.33 -0.33 8.1e-10 Lymphocyte counts; CRC cis rs4332037 0.538 rs4721164 chr7:1932629 C/G cg23422044 chr7:1970798 MAD1L1 -0.5 -6.9 -0.36 2.64e-11 Bipolar disorder; CRC cis rs25422 0.938 rs62421538 chr6:118729703 A/T cg24463073 chr6:118973353 C6orf204 0.51 6.66 0.34 1.13e-10 Renal cell carcinoma; CRC cis rs780096 0.546 rs1260320 chr2:27722416 A/G cg21248554 chr2:27665150 KRTCAP3 0.28 6.46 0.34 3.75e-10 Total body bone mineral density; CRC cis rs8060686 0.641 rs2285910 chr16:68104422 T/C cg08314208 chr16:67682810 RLTPR -0.57 -6.43 -0.33 4.6e-10 HDL cholesterol;Metabolic syndrome; CRC cis rs34375054 0.687 rs35540170 chr12:125669122 C/G cg02766259 chr12:125626809 AACS -0.48 -7.7 -0.39 1.58e-13 Post bronchodilator FEV1/FVC ratio; CRC cis rs2797160 1.000 rs1418642 chr6:125999768 G/A cg05901451 chr6:126070800 HEY2 -0.39 -5.96 -0.31 6.47e-9 Endometrial cancer; CRC cis rs992157 0.698 rs6746089 chr2:219170377 A/G cg00012203 chr2:219082015 ARPC2 0.45 6.74 0.35 7.22e-11 Colorectal cancer; CRC cis rs2455601 1.000 rs11042114 chr11:8919889 C/T cg09997546 chr11:8931473 C11orf17;ST5 -0.52 -6.87 -0.35 3.26e-11 Schizophrenia; CRC cis rs6563842 0.528 rs56340348 chr13:41296371 C/T cg21288729 chr13:41239152 FOXO1 0.41 6.34 0.33 7.52e-10 Eosinophil percentage of granulocytes;Sum eosinophil basophil counts;Eosinophil percentage of white cells; CRC cis rs10788264 0.504 rs1034533 chr10:124032434 A/G cg09507567 chr10:124027408 NA 0.36 7.58 0.39 3.52e-13 Total body bone mineral density; CRC cis rs9733 0.818 rs6694531 chr1:150683512 C/A cg18016565 chr1:150552671 MCL1 -0.42 -6.26 -0.33 1.18e-9 Tonsillectomy; CRC cis rs1475911 0.744 rs12481958 chr21:43517269 A/G cg24372256 chr21:43528868 UMODL1;C21orf128 -0.58 -8.38 -0.42 1.55e-15 IgG glycosylation; CRC cis rs13108904 0.901 rs4974594 chr4:1300480 C/T cg19318889 chr4:1322082 MAEA -0.43 -6.38 -0.33 5.9e-10 Obesity-related traits; CRC cis rs2014572 0.967 rs8100154 chr19:57765432 A/G cg12963866 chr19:57752005 ZNF805 -0.42 -6.17 -0.32 1.98e-9 Hyperactive-impulsive symptoms; CRC cis rs9443645 0.869 rs9343863 chr6:79752792 T/C cg11833968 chr6:79620685 NA -0.36 -6.17 -0.32 1.96e-9 Intelligence (multi-trait analysis); CRC cis rs875971 0.789 rs28815324 chr7:65565776 A/T cg02869306 chr7:64672164 INTS4L1 0.44 6.33 0.33 7.85e-10 Aortic root size; CRC cis rs1552244 0.554 rs3732964 chr3:10048839 C/G cg08888203 chr3:10149979 C3orf24 0.48 7.33 0.37 1.74e-12 Alzheimer's disease; CRC trans rs4843747 0.749 rs13333619 chr16:88072076 C/T cg26811252 chr16:29126840 RRN3P2 0.7 9.53 0.47 3.51e-19 Menopause (age at onset); CRC cis rs2880765 0.835 rs7161880 chr15:86018746 C/T cg17133734 chr15:86042851 AKAP13 0.42 6.72 0.35 8.23e-11 Coronary artery disease; CRC cis rs76878669 0.561 rs56321771 chr11:66161072 C/T cg18002602 chr11:66138449 SLC29A2 0.27 5.84 0.31 1.22e-8 Educational attainment (years of education); CRC cis rs1577917 0.876 rs66986937 chr6:86532191 A/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.59 -7.34 -0.38 1.68e-12 Response to antipsychotic treatment; CRC cis rs9309473 1.000 rs7564890 chr2:73641853 T/C cg20560298 chr2:73613845 ALMS1 -0.48 -5.95 -0.31 6.73e-9 Metabolite levels; CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg26035463 chr12:117627651 FBXO21 -0.49 -6.11 -0.32 2.85e-9 Diisocyanate-induced asthma; CRC cis rs7937682 0.924 rs875258 chr11:111530607 C/A cg19812747 chr11:111475976 SIK2 -0.58 -10.08 -0.49 5.38e-21 Primary sclerosing cholangitis; CRC cis rs2535633 0.820 rs7626551 chr3:52938092 C/G cg15147215 chr3:52552868 STAB1 0.45 7.44 0.38 8.85e-13 Body mass index; CRC cis rs9322193 0.923 rs57012784 chr6:149948827 G/A cg13206674 chr6:150067644 NUP43 0.65 9.75 0.47 6.73e-20 Lung cancer; CRC cis rs801193 0.569 rs11761542 chr7:66218196 G/A cg00343986 chr7:65444356 GUSB 0.44 6.15 0.32 2.3e-9 Aortic root size; CRC cis rs3736485 0.934 rs28648597 chr15:51856066 T/A cg08986416 chr15:51914746 DMXL2 -0.45 -6.56 -0.34 2.12e-10 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs57221529 0.766 rs12521051 chr5:560440 A/G cg14541582 chr5:601475 NA 0.33 6.49 0.34 3.22e-10 Lung disease severity in cystic fibrosis; CRC cis rs9486715 0.830 rs2475023 chr6:96996833 G/A cg18709589 chr6:96969512 KIAA0776 -0.5 -7.47 -0.38 7.12e-13 Headache; CRC cis rs2549003 1.000 rs6894655 chr5:131818649 T/C cg00255919 chr5:131827918 IRF1 0.59 11.88 0.55 2.57e-27 Asthma (sex interaction); CRC cis rs1448094 0.512 rs6539925 chr12:86244358 A/G cg00310523 chr12:86230176 RASSF9 0.33 5.62 0.3 3.97e-8 Major depressive disorder; CRC trans rs7690467 0.777 rs1813031 chr4:133378957 G/A cg20215290 chr12:32831428 DNM1L -0.4 -5.97 -0.31 5.98e-9 Eating disorders; CRC cis rs2721195 0.549 rs2958492 chr8:145919126 C/T cg12270520 chr8:146023939 ZNF517 0.36 5.78 0.3 1.76e-8 Age at first birth; CRC cis rs4822044 0.561 rs132781 chr22:42046122 T/G cg03806693 chr22:41940476 POLR3H 1.01 12.35 0.56 4.95e-29 Cannabis dependence symptom count; CRC cis rs9462846 0.919 rs34433785 chr6:42887693 A/C cg21280719 chr6:42927975 GNMT -0.35 -6.13 -0.32 2.47e-9 Blood protein levels; CRC cis rs728616 0.867 rs61860417 chr10:81734727 C/T cg05935833 chr10:81318306 SFTPA2 -0.7 -7.77 -0.39 9.93e-14 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs6066835 0.867 rs28404239 chr20:47361176 T/C cg18078177 chr20:47281410 PREX1 0.61 5.6 0.3 4.43e-8 Multiple myeloma; CRC cis rs78456975 0.689 rs13391992 chr2:1542153 G/A cg12573674 chr2:1569213 NA -0.78 -8.65 -0.43 2.34e-16 Placebo response in major depressive disorder (% change in symptom score); CRC cis rs7552404 1.000 rs1498315 chr1:76159225 G/A cg10523679 chr1:76189770 ACADM 0.83 11.55 0.54 4.04e-26 Blood metabolite levels;Acylcarnitine levels; CRC cis rs4713118 0.539 rs200967 chr6:27862127 A/G cg08798685 chr6:27730294 NA -0.42 -6.05 -0.32 3.91e-9 Parkinson's disease; CRC cis rs1862618 0.671 rs2591964 chr5:56236900 T/G cg24531977 chr5:56204891 C5orf35 0.67 10.28 0.49 1.1e-21 Initial pursuit acceleration; CRC cis rs1552244 0.515 rs111560858 chr3:10166845 G/A cg10729496 chr3:10149963 C3orf24 0.49 5.65 0.3 3.52e-8 Alzheimer's disease; CRC cis rs4665809 1.000 rs6546744 chr2:26302161 A/G cg26119090 chr2:26468346 HADHA;HADHB -0.61 -7.9 -0.4 4.28e-14 Gut microbiome composition (summer); CRC cis rs4332037 0.851 rs28728306 chr7:1961814 C/A cg23422044 chr7:1970798 MAD1L1 -0.64 -8.1 -0.41 1.08e-14 Bipolar disorder; CRC cis rs10946940 0.965 rs10946935 chr6:27501345 T/C cg06470822 chr6:28175283 NA -0.5 -6.85 -0.35 3.7e-11 Systemic lupus erythematosus; CRC cis rs7937682 0.889 rs567859 chr11:111486738 A/G cg09085632 chr11:111637200 PPP2R1B -0.98 -19.21 -0.73 1.09e-55 Primary sclerosing cholangitis; CRC trans rs12940923 0.935 rs11079342 chr17:56367633 G/C cg16900910 chr15:72789182 ARIH1 0.52 5.97 0.31 6.14e-9 Circulating myeloperoxidase levels (plasma); CRC cis rs7937682 0.737 rs518294 chr11:111424716 A/T cg19812747 chr11:111475976 SIK2 -0.47 -7.79 -0.39 8.56e-14 Primary sclerosing cholangitis; CRC cis rs1555895 0.656 rs7919815 chr10:842062 C/G cg10556349 chr10:835070 NA -0.38 -7.01 -0.36 1.34e-11 Survival in rectal cancer; CRC cis rs3026101 0.671 rs1806222 chr17:5289676 C/T cg25236894 chr17:5323110 RPAIN;NUP88 0.42 6.82 0.35 4.25e-11 Body mass index; CRC cis rs34311866 0.808 rs17783233 chr4:976598 T/C cg14530993 chr4:882597 GAK 0.61 5.84 0.31 1.26e-8 Parkinson's disease; CRC cis rs6988636 1.000 rs59834873 chr8:124188824 G/T cg27053337 chr8:124217698 FAM83A 0.47 7.15 0.37 5.57e-12 Urinary uromodulin levels; CRC cis rs10504229 0.593 rs116916898 chr8:57984958 G/A cg08219700 chr8:58056026 NA 0.57 5.83 0.31 1.32e-8 Developmental language disorder (linguistic errors); CRC cis rs12580194 0.556 rs11171433 chr12:55757797 A/T cg19537932 chr12:55886519 OR6C68 -0.72 -9.07 -0.45 1.12e-17 Cancer; CRC cis rs9372498 0.536 rs62424198 chr6:118827247 A/G cg01339444 chr6:118972232 C6orf204 0.53 6.02 0.32 4.58e-9 Diastolic blood pressure; CRC trans rs637571 0.522 rs12792888 chr11:65761446 C/T cg17712092 chr4:129076599 LARP1B 0.77 12.82 0.58 8.83e-31 Eosinophil percentage of white cells; CRC cis rs853679 0.546 rs200977 chr6:27854301 T/C cg15845792 chr6:28175446 NA 0.71 5.88 0.31 9.84e-9 Depression; CRC cis rs6570726 0.935 rs385134 chr6:145851005 C/T cg05347473 chr6:146136440 FBXO30 0.38 6.09 0.32 3.19e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs12024301 0.557 rs16828985 chr1:183609830 G/A cg11505048 chr1:183622726 RGL1;APOBEC4 0.81 7.01 0.36 1.33e-11 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs28386778 0.863 rs3760256 chr17:61821161 A/G cg06873352 chr17:61820015 STRADA 0.76 14.29 0.62 2.31e-36 Prudent dietary pattern; CRC cis rs801193 0.761 rs2659888 chr7:66230171 T/G cg11764359 chr7:65958608 NA 0.53 8.14 0.41 8.27e-15 Aortic root size; CRC cis rs501120 0.706 rs1657346 chr10:44777560 G/C cg09554077 chr10:44749378 NA 0.74 8.09 0.41 1.16e-14 Coronary artery disease;Coronary heart disease; CRC cis rs9814567 1.000 rs6772896 chr3:134203347 C/T cg06541857 chr3:134203789 ANAPC13;CEP63 -0.39 -5.76 -0.3 1.88e-8 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs6691722 0.506 rs11587667 chr1:24715435 C/G cg18323236 chr1:24743029 NIPAL3 0.45 6.75 0.35 6.61e-11 Response to interferon beta in multiple sclerosis; CRC cis rs9814567 0.727 rs4245908 chr3:134349205 A/T cg06109529 chr3:134205091 CEP63;ANAPC13 -0.62 -8.82 -0.44 6.83e-17 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs7945705 0.967 rs10769973 chr11:8928615 C/G cg12365402 chr11:9010492 NRIP3 0.5 8.04 0.41 1.62e-14 Hemoglobin concentration; CRC cis rs7044106 0.791 rs7036766 chr9:123479621 G/A cg14255062 chr9:123606675 PSMD5;LOC253039 0.49 7.3 0.37 2.23e-12 Hip circumference adjusted for BMI; CRC cis rs873946 0.586 rs12251911 chr10:134570595 A/G cg06453172 chr10:134556979 INPP5A -0.65 -8.32 -0.42 2.35e-15 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CRC cis rs6088590 1.000 rs55753039 chr20:33394940 C/T cg08999081 chr20:33150536 PIGU 0.52 8.69 0.43 1.75e-16 Coronary artery disease; CRC cis rs1153858 1.000 rs1554521 chr15:45664189 A/T cg21132104 chr15:45694354 SPATA5L1 -0.61 -8.85 -0.44 5.41e-17 Homoarginine levels; CRC cis rs6754311 0.731 rs745500 chr2:136583192 G/A cg15123519 chr2:136567270 LCT 0.33 6.42 0.33 4.87e-10 Mosquito bite size; CRC cis rs58688157 0.639 rs60568231 chr11:575553 A/T cg01842473 chr11:617407 IRF7;MUPCDH -0.54 -6.41 -0.33 5.15e-10 Systemic lupus erythematosus; CRC cis rs7605827 0.897 rs10202600 chr2:15514461 T/C cg19274914 chr2:15703543 NA 0.38 5.78 0.3 1.78e-8 Educational attainment (years of education); CRC cis rs17666538 0.585 rs4735812 chr8:607766 C/G cg07685180 chr8:600429 NA 0.75 7.14 0.37 5.86e-12 IgG glycosylation; CRC cis rs7829975 0.659 rs4382480 chr8:8721473 C/T cg06636001 chr8:8085503 FLJ10661 0.58 9.14 0.45 6.75e-18 Mood instability; CRC cis rs6502050 0.805 rs7406858 chr17:80080623 G/A cg13198984 chr17:80129470 CCDC57 -0.48 -8.58 -0.43 3.8e-16 Life satisfaction; CRC cis rs2067615 0.524 rs10861646 chr12:107071182 C/T cg13491945 chr12:107078410 RFX4 0.36 6.16 0.32 2.13e-9 Heart rate; CRC cis rs17234274 0.622 rs2128495 chr11:23234356 C/T cg05245346 chr11:23248277 NA 0.34 5.63 0.3 3.79e-8 Cancer; CRC trans rs7937682 1.000 rs7937682 chr11:111579939 C/G cg18187862 chr3:45730750 SACM1L 0.54 7.72 0.39 1.45e-13 Primary sclerosing cholangitis; CRC cis rs875971 1.000 rs1968225 chr7:65874773 T/C cg18876405 chr7:65276391 NA 0.52 9.04 0.45 1.37e-17 Aortic root size; CRC cis rs9287719 0.649 rs6714787 chr2:10729032 C/T cg00105475 chr2:10696890 NA 0.44 7.0 0.36 1.43e-11 Prostate cancer; CRC cis rs9486715 0.867 rs4438964 chr6:96917563 T/G cg18709589 chr6:96969512 KIAA0776 0.49 7.27 0.37 2.69e-12 Headache; CRC cis rs2811415 0.597 rs13083602 chr3:127758532 A/G cg13719885 chr3:127795394 NA -0.37 -5.67 -0.3 3.19e-8 Lung function (FEV1/FVC); CRC trans rs4942242 0.663 rs7332737 chr13:44215043 C/T cg19169023 chr15:41853346 TYRO3 -0.59 -8.32 -0.42 2.43e-15 Response to tocilizumab in rheumatoid arthritis; CRC cis rs8060686 0.516 rs8062085 chr16:68289313 C/A cg26727032 chr16:67993705 SLC12A4 -0.63 -8.97 -0.44 2.3e-17 HDL cholesterol;Metabolic syndrome; CRC cis rs1046896 0.627 rs7225515 chr17:80795783 C/T cg16060761 chr17:80687452 NA -0.47 -6.06 -0.32 3.8e-9 Glycated hemoglobin levels; CRC cis rs853679 0.517 rs9380061 chr6:28132803 T/C cg18032046 chr6:28092343 ZSCAN16 -0.51 -5.93 -0.31 7.47e-9 Depression; CRC trans rs916888 0.779 rs199498 chr17:44865603 A/G cg07870213 chr5:140052090 DND1 0.73 8.67 0.43 2.01e-16 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs6496667 0.821 rs28459968 chr15:90919002 C/G cg04176472 chr15:90893244 GABARAPL3 0.6 7.88 0.4 4.81e-14 Rheumatoid arthritis; CRC cis rs7917772 0.503 rs1409310 chr10:104282265 T/C cg11453585 chr10:104263688 ACTR1A;SUFU 0.91 17.47 0.69 8.43e-49 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC cis rs807669 0.835 rs1780639 chr22:19174603 T/C cg02655711 chr22:19163373 SLC25A1 0.98 20.12 0.74 2.92e-59 Metabolite levels; CRC cis rs4713118 0.955 rs9368529 chr6:27684631 G/A cg12172441 chr6:28176163 NA 0.46 5.99 0.31 5.42e-9 Parkinson's disease; CRC cis rs2730245 0.527 rs842702 chr7:158696814 C/T cg24397884 chr7:158709396 WDR60 0.93 11.38 0.53 1.56e-25 Height; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg26643908 chr2:36825150 FEZ2 0.36 6.18 0.32 1.88e-9 Liver disease severity in Alagille syndrome; CRC cis rs7552404 0.924 rs1146581 chr1:76213024 T/G cg10523679 chr1:76189770 ACADM 0.8 12.14 0.56 2.9e-28 Blood metabolite levels;Acylcarnitine levels; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg15733507 chr9:139965275 C9orf140 0.43 6.69 0.35 9.62e-11 Liver disease severity in Alagille syndrome; CRC cis rs10504229 1.000 rs73607874 chr8:58173433 G/C cg02725872 chr8:58115012 NA -0.38 -6.43 -0.33 4.44e-10 Developmental language disorder (linguistic errors); CRC cis rs853679 0.517 rs9393887 chr6:28059020 G/A cg06470822 chr6:28175283 NA 0.99 13.25 0.59 2.03e-32 Depression; CRC trans rs208520 1.000 rs12194996 chr6:66973366 G/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.84 10.1 0.49 4.52e-21 Exhaled nitric oxide output; CRC cis rs10504229 1.000 rs66796009 chr8:58174529 G/A cg01721255 chr8:58191610 C8orf71 0.49 6.18 0.32 1.88e-9 Developmental language disorder (linguistic errors); CRC cis rs7216064 1.000 rs4318247 chr17:65882172 A/G cg12091567 chr17:66097778 LOC651250 -0.67 -7.74 -0.39 1.24e-13 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CRC trans rs1005277 0.540 rs4934907 chr10:38015230 A/C cg27523141 chr10:43048294 ZNF37B 0.45 6.46 0.34 3.84e-10 Extrinsic epigenetic age acceleration; CRC cis rs7617773 0.817 rs9818937 chr3:48325281 G/A cg11946769 chr3:48343235 NME6 0.64 8.85 0.44 5.61e-17 Coronary artery disease; CRC cis rs6502050 0.835 rs9898697 chr17:80100498 A/G cg02741985 chr17:80059408 CCDC57 0.43 7.18 0.37 4.56e-12 Life satisfaction; CRC cis rs59698941 0.550 rs12652469 chr5:132182765 A/G cg14825688 chr5:132208181 LEAP2 -0.37 -5.88 -0.31 9.93e-9 Apolipoprotein A-IV levels; CRC trans rs7267979 1.000 rs6050631 chr20:25431749 C/T cg17903999 chr18:56338584 MALT1 -0.41 -6.7 -0.35 9.07e-11 Liver enzyme levels (alkaline phosphatase); CRC cis rs1712517 0.545 rs3740381 chr10:105046689 G/C cg04362960 chr10:104952993 NT5C2 -0.47 -6.15 -0.32 2.29e-9 Migraine; CRC cis rs3110496 0.685 rs550818 chr17:27901975 A/G cg26525008 chr17:28256777 EFCAB5;SSH2 0.47 6.3 0.33 9.42e-10 Height; CRC cis rs7208859 0.673 rs9889968 chr17:29220128 C/A cg14008862 chr17:28927542 LRRC37B2 0.55 5.75 0.3 2.04e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs3806843 0.583 rs408652 chr5:140330013 T/G cg19875535 chr5:140030758 IK 0.4 6.07 0.32 3.58e-9 Depressive symptoms (multi-trait analysis); CRC cis rs1150668 0.796 rs2247002 chr6:28397951 G/C cg03623178 chr6:28175578 NA 0.48 7.1 0.36 7.87e-12 Pubertal anthropometrics; CRC cis rs523522 0.962 rs603574 chr12:120998443 A/G cg27279351 chr12:120934652 DYNLL1 0.75 10.82 0.51 1.46e-23 High light scatter reticulocyte count; CRC cis rs9372253 1.000 rs11153232 chr6:110716252 G/T cg01119278 chr6:110721349 DDO 0.37 6.06 0.32 3.81e-9 Platelet distribution width; CRC cis rs10504229 0.775 rs56082079 chr8:58163732 T/C cg24829409 chr8:58192753 C8orf71 -0.61 -8.09 -0.41 1.13e-14 Developmental language disorder (linguistic errors); CRC cis rs6502050 0.805 rs9915071 chr17:80119138 T/C cg25804541 chr17:80189381 SLC16A3 -0.31 -5.95 -0.31 6.84e-9 Life satisfaction; CRC cis rs7552404 1.000 rs12123977 chr1:76209754 A/G cg22875332 chr1:76189707 ACADM -0.62 -8.33 -0.42 2.19e-15 Blood metabolite levels;Acylcarnitine levels; CRC trans rs7937682 0.924 rs4630327 chr11:111539327 C/T cg18187862 chr3:45730750 SACM1L -0.45 -6.77 -0.35 6.01e-11 Primary sclerosing cholangitis; CRC cis rs17253792 0.545 rs12893610 chr14:56016347 C/T cg01858014 chr14:56050164 KTN1 -0.9 -7.03 -0.36 1.19e-11 Putamen volume; CRC cis rs28386778 0.897 rs894408 chr17:61896814 C/T cg07362569 chr17:61921086 SMARCD2 0.38 5.95 0.31 6.87e-9 Prudent dietary pattern; CRC trans rs11039798 0.588 rs12278284 chr11:48612063 G/C cg15704280 chr7:45808275 SEPT13 0.65 7.04 0.36 1.13e-11 Axial length; CRC cis rs728616 0.867 rs61859022 chr10:81860799 G/A cg11900509 chr10:81946545 ANXA11 -0.55 -5.81 -0.31 1.46e-8 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs2153535 0.580 rs4960423 chr6:8477210 C/T cg07606381 chr6:8435919 SLC35B3 0.68 10.9 0.51 8.26e-24 Motion sickness; CRC cis rs6502050 0.835 rs12950475 chr17:80118924 T/C cg11859384 chr17:80120422 CCDC57 -0.36 -5.75 -0.3 2.06e-8 Life satisfaction; CRC cis rs9443645 0.901 rs1572585 chr6:79690576 C/T cg05283184 chr6:79620031 NA -0.59 -9.27 -0.45 2.6e-18 Intelligence (multi-trait analysis); CRC cis rs2949837 0.581 rs2965072 chr7:45980751 G/T cg04727332 chr7:45960243 IGFBP3 0.37 5.84 0.31 1.26e-8 Sitting height ratio; CRC cis rs12540874 0.931 rs4245555 chr7:50661409 A/G cg18232548 chr7:50535776 DDC -0.45 -6.26 -0.33 1.21e-9 Systemic sclerosis; CRC cis rs763014 0.932 rs2384972 chr16:674424 G/A cg07343612 chr16:622815 PIGQ -0.81 -13.73 -0.6 3.24e-34 Height; CRC cis rs765787 0.530 rs4442750 chr15:45535328 G/T cg24006582 chr15:45444508 DUOX1 -0.57 -8.79 -0.44 8.5e-17 Uric acid levels; CRC cis rs929354 0.772 rs2051876 chr7:157009037 A/G cg16102536 chr7:156981717 UBE3C -0.4 -6.71 -0.35 8.27e-11 Body mass index; CRC cis rs265548 0.510 rs28415068 chr19:17910582 T/A cg16744531 chr19:17905626 B3GNT3 0.51 8.5 0.42 6.81e-16 Tumor biomarkers; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg23134520 chr20:44485949 ACOT8;ZSWIM3 0.44 6.17 0.32 1.96e-9 Response to antipsychotic treatment; CRC cis rs778371 0.578 rs2675956 chr2:233753340 G/A cg25237894 chr2:233734115 C2orf82 -0.39 -6.03 -0.32 4.45e-9 Schizophrenia; CRC cis rs10512697 0.803 rs71594961 chr5:3578056 T/C cg19473799 chr5:3511975 NA -0.73 -5.8 -0.3 1.53e-8 Immune response to smallpox vaccine (IL-6); CRC cis rs13064411 0.501 rs13092925 chr3:113209375 C/G cg18753928 chr3:113234510 CCDC52 -0.53 -8.2 -0.41 5.32e-15 Response to simvastatin treatment (PCSK9 protein level change); CRC cis rs875971 0.862 rs12537823 chr7:65720884 C/T cg11764359 chr7:65958608 NA 0.6 9.17 0.45 5.11e-18 Aortic root size; CRC cis rs6679073 1.000 rs10494874 chr1:205754688 C/G cg23034840 chr1:205782522 SLC41A1 0.53 7.64 0.39 2.36e-13 Prostate-specific antigen levels; CRC cis rs3733585 0.725 rs6449201 chr4:9973894 C/T cg00071950 chr4:10020882 SLC2A9 -0.55 -9.81 -0.48 4.25e-20 Cleft plate (environmental tobacco smoke interaction); CRC cis rs1862618 0.853 rs252921 chr5:56137787 G/A cg12311346 chr5:56204834 C5orf35 -0.79 -10.49 -0.5 2.05e-22 Initial pursuit acceleration; CRC cis rs9487051 1.000 rs1341271 chr6:109617542 A/T cg01475377 chr6:109611718 NA -0.46 -8.05 -0.41 1.5e-14 Reticulocyte fraction of red cells; CRC cis rs728616 0.510 rs17617406 chr10:82174556 C/T cg11900509 chr10:81946545 ANXA11 0.52 5.96 0.31 6.55e-9 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs7727544 0.642 rs7705189 chr5:131623358 C/T cg02033258 chr5:131593261 PDLIM4 -0.33 -6.26 -0.33 1.21e-9 Blood metabolite levels; CRC trans rs9409565 0.826 rs4612412 chr9:97208627 C/G cg05679027 chr9:99775184 HIATL2 -0.41 -6.25 -0.33 1.3e-9 Colorectal cancer (alcohol consumption interaction); CRC cis rs9311474 0.629 rs13081028 chr3:52555316 G/A cg13284614 chr3:52569169 NT5DC2;LOC440957 0.37 5.92 0.31 8.27e-9 Electroencephalogram traits; CRC cis rs6942756 0.531 rs7800983 chr7:128971130 C/T cg02491457 chr7:128862824 NA 0.53 7.7 0.39 1.65e-13 White matter hyperintensity burden; CRC cis rs1448094 0.511 rs4559760 chr12:86149414 G/A cg00310523 chr12:86230176 RASSF9 -0.36 -5.92 -0.31 8.25e-9 Major depressive disorder; CRC cis rs8180040 0.966 rs7628631 chr3:47560863 C/T cg27129171 chr3:47204927 SETD2 -0.62 -9.93 -0.48 1.69e-20 Colorectal cancer; CRC cis rs2380220 0.808 rs2613551 chr6:95914740 G/A cg04719120 chr6:96025338 MANEA -0.53 -5.88 -0.31 9.93e-9 Behavioural disinhibition (generation interaction); CRC cis rs2991971 0.967 rs937291 chr1:45957039 G/T cg15605315 chr1:45957053 TESK2 0.42 6.7 0.35 9.26e-11 High light scatter reticulocyte count; CRC cis rs1707322 0.835 rs946525 chr1:46487277 A/T cg03146154 chr1:46216737 IPP -0.5 -6.97 -0.36 1.72e-11 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs10504229 0.815 rs55855654 chr8:58164299 T/G cg11062466 chr8:58055876 NA 0.45 5.81 0.3 1.49e-8 Developmental language disorder (linguistic errors); CRC cis rs4665809 0.590 rs7588328 chr2:26469788 G/A cg25036284 chr2:26402008 FAM59B 0.62 7.86 0.4 5.64e-14 Gut microbiome composition (summer); CRC cis rs56283067 0.847 rs1418432 chr6:44691372 T/C cg18551225 chr6:44695536 NA -0.41 -5.96 -0.31 6.36e-9 Total body bone mineral density; CRC cis rs6938 0.534 rs7495739 chr15:75185670 C/T cg18612461 chr15:75251733 NA -0.37 -5.6 -0.3 4.41e-8 Breast cancer; CRC cis rs7786808 0.505 rs67537656 chr7:158192646 C/T cg15440763 chr7:158190612 PTPRN2 -0.42 -6.77 -0.35 5.99e-11 Obesity-related traits; CRC cis rs2204008 0.580 rs36118148 chr12:38411812 G/A cg26384229 chr12:38710491 ALG10B -0.52 -7.46 -0.38 7.69e-13 Bladder cancer; CRC cis rs6502050 0.799 rs4789674 chr17:80123200 G/A cg19223190 chr17:80058835 NA 0.39 6.3 0.33 9.57e-10 Life satisfaction; CRC trans rs1814175 0.616 rs1722020 chr11:49904189 G/A cg15704280 chr7:45808275 SEPT13 -0.95 -16.76 -0.68 5.2e-46 Height; CRC cis rs6951245 1.000 rs74652290 chr7:1090109 G/A cg22907277 chr7:1156413 C7orf50 0.67 7.12 0.37 7.02e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs4919694 1.000 rs12266291 chr10:104806884 G/A cg04362960 chr10:104952993 NT5C2 1.11 10.44 0.5 3.09e-22 Arsenic metabolism; CRC cis rs597539 0.652 rs604524 chr11:68629929 G/A cg21963583 chr11:68658836 MRPL21 0.58 10.56 0.5 1.2e-22 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC trans rs6956675 0.881 rs1829737 chr7:62576000 G/A cg01314568 chr7:57830625 NA -0.67 -9.05 -0.45 1.24e-17 Obesity-related traits; CRC cis rs10028773 0.700 rs7671797 chr4:120248157 A/G cg24375607 chr4:120327624 NA 0.48 7.63 0.39 2.56e-13 Educational attainment; CRC cis rs7927592 0.731 rs2156463 chr11:68386311 T/C cg01657329 chr11:68192670 LRP5 -0.57 -9.4 -0.46 9.34e-19 Total body bone mineral density; CRC cis rs873946 0.648 rs35417213 chr10:134553749 A/G cg26818010 chr10:134567672 INPP5A -0.69 -9.02 -0.45 1.54e-17 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CRC cis rs7208859 0.614 rs28758251 chr17:29223312 A/T cg01831904 chr17:28903510 LRRC37B2 -0.56 -5.83 -0.31 1.35e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs7727544 0.507 rs11741341 chr5:131570218 A/G cg02033258 chr5:131593261 PDLIM4 0.46 8.67 0.43 2.04e-16 Blood metabolite levels; CRC cis rs950027 0.595 rs2486288 chr15:45712339 T/C cg10760299 chr15:45669010 GATM 0.36 5.61 0.3 4.26e-8 Response to fenofibrate (adiponectin levels); CRC cis rs4819052 0.851 rs2877018 chr21:46658306 G/A cg19498844 chr21:46707878 POFUT2;LOC642852 0.77 10.99 0.52 3.97e-24 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs7809950 0.871 rs11771278 chr7:107285925 C/T cg23024343 chr7:107201750 COG5 0.44 6.59 0.34 1.72e-10 Coronary artery disease; CRC cis rs644799 0.763 rs2950521 chr11:95536870 G/A cg03916912 chr11:95522834 CEP57;FAM76B 0.93 17.68 0.7 1.19e-49 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs11098499 0.954 rs3890049 chr4:120326283 T/A cg09307838 chr4:120376055 NA 0.72 11.03 0.52 2.79e-24 Corneal astigmatism; CRC cis rs4862750 0.624 rs34414639 chr4:187873417 C/A cg22105103 chr4:187893119 NA 0.6 10.52 0.5 1.67e-22 Lobe attachment (rater-scored or self-reported); CRC trans rs75804782 0.641 rs1030786 chr2:239361150 A/G cg01134436 chr17:81009848 B3GNTL1 0.72 6.54 0.34 2.32e-10 Morning vs. evening chronotype;Chronotype; CRC cis rs6502050 0.764 rs35416122 chr17:80119006 A/G cg19223190 chr17:80058835 NA 0.39 6.23 0.32 1.43e-9 Life satisfaction; CRC cis rs10946940 0.896 rs12208078 chr6:27498581 G/A cg02683197 chr6:28174875 NA -0.53 -7.25 -0.37 2.99e-12 Systemic lupus erythematosus; CRC cis rs870825 0.550 rs28525282 chr4:185631468 T/C cg04058563 chr4:185651563 MLF1IP 0.72 9.2 0.45 4.18e-18 Blood protein levels; CRC cis rs1395 0.744 rs11126934 chr2:27476613 T/C cg14242246 chr2:27434262 C2orf28;SLC5A6 0.33 6.25 0.33 1.26e-9 Blood metabolite levels; CRC trans rs10277209 0.932 rs1406296 chr7:109012340 T/C cg13575011 chr19:16022472 NA 0.48 5.98 0.31 5.91e-9 Prostate cancer (SNP x SNP interaction); CRC cis rs6502050 0.698 rs6502076 chr17:80121978 A/G cg13198984 chr17:80129470 CCDC57 0.47 8.35 0.42 1.88e-15 Life satisfaction; CRC cis rs12762955 0.528 rs10903358 chr10:1102386 G/A cg26597838 chr10:835615 NA 0.8 9.13 0.45 7.07e-18 Response to angiotensin II receptor blocker therapy; CRC trans rs2727020 0.615 rs4980435 chr11:49591576 G/A cg03929089 chr4:120376271 NA -0.92 -17.55 -0.7 3.8e-49 Coronary artery disease; CRC trans rs7615952 0.576 rs66671308 chr3:125793526 T/G cg07211511 chr3:129823064 LOC729375 -0.7 -9.4 -0.46 9.41e-19 Blood pressure (smoking interaction); CRC trans rs61931739 0.534 rs10844774 chr12:34166764 C/T cg26384229 chr12:38710491 ALG10B 0.55 7.0 0.36 1.44e-11 Morning vs. evening chronotype; CRC cis rs694739 0.536 rs11231740 chr11:64046641 C/T cg02228329 chr11:64053129 BAD;GPR137 -0.47 -6.94 -0.36 2.13e-11 Alopecia areata;Crohn's disease;Psoriasis vulgaris; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg13410609 chr19:50291885 AP2A1 -0.37 -6.04 -0.32 4.2e-9 Liver disease severity in Alagille syndrome; CRC cis rs4743820 0.590 rs10991785 chr9:93917111 C/T cg14446406 chr9:93919335 NA 0.77 13.47 0.6 2.94e-33 Ulcerative colitis;Inflammatory bowel disease; CRC cis rs1728785 0.818 rs11648503 chr16:68598938 G/A cg02972257 chr16:68554789 NA -0.66 -7.85 -0.4 5.99e-14 Ulcerative colitis; CRC cis rs11679072 1.000 rs13410440 chr2:240447304 C/T cg03276489 chr2:240449683 NA 0.87 9.07 0.45 1.13e-17 Blood pressure (smoking interaction); CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg13834670 chr9:129677390 RALGPS1 -0.44 -7.18 -0.37 4.63e-12 Myopia (pathological); CRC cis rs9486715 0.793 rs2499777 chr6:97013814 T/C cg06623918 chr6:96969491 KIAA0776 -1.03 -20.89 -0.76 2.86e-62 Headache; CRC cis rs7772486 0.720 rs6901888 chr6:146023144 A/G cg23711669 chr6:146136114 FBXO30 -0.73 -12.51 -0.57 1.22e-29 Lobe attachment (rater-scored or self-reported); CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg19998654 chr2:37458983 CEBPZ;C2orf56 0.42 6.75 0.35 6.52e-11 Obesity-related traits; CRC cis rs853679 0.517 rs9348796 chr6:28126202 A/G cg06470822 chr6:28175283 NA 1.03 13.59 0.6 1.04e-33 Depression; CRC cis rs3806843 0.676 rs1583005 chr5:140031537 G/A cg19875535 chr5:140030758 IK -0.67 -11.56 -0.54 3.65e-26 Depressive symptoms (multi-trait analysis); CRC trans rs7395662 0.591 rs4882138 chr11:48619321 A/G cg03929089 chr4:120376271 NA -0.46 -6.52 -0.34 2.68e-10 HDL cholesterol; CRC cis rs9660180 0.967 rs12034740 chr1:1728969 C/A cg05132306 chr1:1846340 CALML6 -0.42 -6.49 -0.34 3.18e-10 Body mass index; CRC cis rs1799949 1.000 rs33946455 chr17:41321846 C/T cg05368731 chr17:41323189 NBR1 0.69 10.52 0.5 1.69e-22 Menopause (age at onset); CRC cis rs6502050 0.835 rs6502059 chr17:80082886 T/C cg11859384 chr17:80120422 CCDC57 0.37 5.82 0.31 1.36e-8 Life satisfaction; CRC cis rs992157 1.000 rs4674280 chr2:219141458 C/G cg04731861 chr2:219085781 ARPC2 0.28 5.89 0.31 9.6e-9 Colorectal cancer; CRC cis rs6062302 0.522 rs2297428 chr20:62221766 C/T cg16989086 chr20:62203971 PRIC285 0.47 6.04 0.32 4.21e-9 Glioblastoma; CRC cis rs6912958 0.559 rs6921504 chr6:88058972 A/G cg08069147 chr6:88032118 GJB7;C6orf162 0.68 11.07 0.52 1.98e-24 Monocyte percentage of white cells; CRC cis rs597539 0.616 rs72945243 chr11:68633358 T/C cg06112835 chr11:68658793 MRPL21 0.42 6.9 0.36 2.74e-11 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg25887850 chr20:44509743 ZSWIM1 0.47 6.73 0.35 7.65e-11 Response to antipsychotic treatment; CRC cis rs2019137 0.560 rs6707386 chr2:113981022 G/A cg23564664 chr2:113997917 PAX8;LOC654433;LOC440839 -0.38 -6.11 -0.32 2.74e-9 Lymphocyte counts; CRC cis rs4689592 0.513 rs3857178 chr4:7066516 G/A cg26116260 chr4:7069785 GRPEL1 0.98 14.93 0.64 7.78e-39 Monocyte percentage of white cells; CRC cis rs6496667 0.909 rs56733567 chr15:90881557 G/T cg04176472 chr15:90893244 GABARAPL3 0.57 6.62 0.34 1.45e-10 Rheumatoid arthritis; CRC trans rs2303319 0.504 rs16846047 chr2:162561946 T/C cg12500891 chr11:57225987 NA -0.67 -6.03 -0.32 4.51e-9 Cognitive function; CRC cis rs10540 1.000 rs71487292 chr11:486076 G/A cg03576123 chr11:487126 PTDSS2 -1.1 -10.57 -0.5 1.15e-22 Body mass index; CRC cis rs9649213 0.593 rs7803372 chr7:97992257 A/G cg00277769 chr7:97922759 BAIAP2L1 -0.6 -10.43 -0.5 3.32e-22 Prostate cancer (SNP x SNP interaction); CRC cis rs11190604 0.767 rs11190531 chr10:102187310 T/A cg07080220 chr10:102295463 HIF1AN 0.47 5.75 0.3 2.08e-8 Palmitoleic acid (16:1n-7) levels; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg11713515 chr10:18940758 NSUN6 0.37 6.16 0.32 2.08e-9 Liver disease severity in Alagille syndrome; CRC cis rs6570726 0.791 rs9403730 chr6:145907233 C/T cg13319975 chr6:146136371 FBXO30 -0.42 -6.28 -0.33 1.04e-9 Lobe attachment (rater-scored or self-reported); CRC trans rs2303319 0.504 rs1006427 chr2:162592328 T/C cg13490827 chr1:46269305 MAST2 -0.69 -6.0 -0.31 5.24e-9 Cognitive function; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg26281728 chr15:85923949 AKAP13 0.42 6.62 0.34 1.43e-10 Liver disease severity in Alagille syndrome; CRC cis rs28386778 0.897 rs2727295 chr17:61887693 C/T cg25654072 chr17:61904446 PSMC5;FTSJ3 0.63 9.9 0.48 2.16e-20 Prudent dietary pattern; CRC cis rs4665809 0.590 rs7606351 chr2:26292545 A/C cg22920501 chr2:26401640 FAM59B -0.56 -7.33 -0.37 1.78e-12 Gut microbiome composition (summer); CRC cis rs35110281 0.807 rs9976441 chr21:45046591 G/A cg04455712 chr21:45112962 RRP1B 0.39 7.55 0.38 4.33e-13 Mean corpuscular volume; CRC cis rs9372498 0.536 rs62422235 chr6:118971913 G/A cg18833306 chr6:118973337 C6orf204 0.46 5.66 0.3 3.24e-8 Diastolic blood pressure; CRC cis rs6545883 0.524 rs12713435 chr2:61499789 C/T cg10580144 chr2:61372316 C2orf74 -0.35 -7.63 -0.39 2.59e-13 Tuberculosis; CRC cis rs6912958 0.712 rs6908386 chr6:88354746 T/C cg08069147 chr6:88032118 GJB7;C6orf162 -0.56 -8.42 -0.42 1.16e-15 Monocyte percentage of white cells; CRC cis rs6951245 1.000 rs79443843 chr7:1075245 G/A cg26224354 chr7:1096374 C7orf50;GPR146 -0.88 -11.04 -0.52 2.62e-24 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs3796352 0.667 rs11720228 chr3:52877270 G/A cg06204229 chr3:52865917 ITIH4 0.58 6.81 0.35 4.57e-11 Immune reponse to smallpox (secreted IL-2); CRC cis rs9291683 0.588 rs13121211 chr4:9999539 A/G cg00071950 chr4:10020882 SLC2A9 0.59 11.25 0.53 4.68e-25 Bone mineral density; CRC cis rs1448094 0.511 rs17279289 chr12:86162792 T/G cg00310523 chr12:86230176 RASSF9 0.36 5.91 0.31 8.34e-9 Major depressive disorder; CRC cis rs1577917 0.883 rs2166664 chr6:86596622 T/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.45 -5.92 -0.31 8.07e-9 Response to antipsychotic treatment; CRC cis rs853679 0.517 rs9380062 chr6:28137569 G/A cg15845792 chr6:28175446 NA 1.04 13.89 0.61 7.67e-35 Depression; CRC cis rs9914988 0.887 rs34644886 chr17:27168327 T/C cg20469991 chr17:27169893 C17orf63 -0.59 -7.02 -0.36 1.28e-11 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs4819052 0.851 rs2838828 chr21:46663423 A/G cg11663144 chr21:46675770 NA -0.83 -14.3 -0.62 1.99e-36 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs2204008 0.687 rs1733404 chr12:38123395 G/T cg26384229 chr12:38710491 ALG10B -0.63 -8.91 -0.44 3.66e-17 Bladder cancer; CRC cis rs1320333 0.772 rs2867136 chr2:701455 T/C cg20966539 chr2:681320 NA -0.56 -5.78 -0.3 1.73e-8 Obesity-related traits; CRC cis rs4665809 1.000 rs10170359 chr2:26272219 G/T cg22920501 chr2:26401640 FAM59B -0.57 -7.88 -0.4 4.86e-14 Gut microbiome composition (summer); CRC cis rs78456975 1.000 rs72778004 chr2:1571892 T/A cg26248373 chr2:1572462 NA -0.71 -8.13 -0.41 8.56e-15 Placebo response in major depressive disorder (% change in symptom score); CRC cis rs1552244 1.000 rs111392584 chr3:10075991 A/G cg08888203 chr3:10149979 C3orf24 0.73 10.08 0.49 5.45e-21 Alzheimer's disease; CRC cis rs17065868 0.764 rs6561176 chr13:45015449 T/C cg10246903 chr13:45222710 NA 0.57 6.3 0.33 9.58e-10 Antineutrophil cytoplasmic antibody-associated vasculitis; CRC cis rs2070677 0.668 rs7899159 chr10:135431451 C/T cg16964102 chr10:135390573 NA 0.44 5.81 0.31 1.46e-8 Gout; CRC cis rs6088590 0.648 rs6059991 chr20:33280836 C/T cg08999081 chr20:33150536 PIGU 0.58 10.56 0.5 1.18e-22 Coronary artery disease; CRC cis rs7605827 0.930 rs4140715 chr2:15515899 G/A cg19274914 chr2:15703543 NA 0.38 5.78 0.3 1.78e-8 Educational attainment (years of education); CRC trans rs12599106 0.792 rs11648801 chr16:34360980 C/T cg26668828 chr6:292823 DUSP22 -0.61 -8.95 -0.44 2.6e-17 Menopause (age at onset); CRC cis rs6952808 0.965 rs4719318 chr7:1887930 G/A cg22963979 chr7:1858916 MAD1L1 -0.59 -9.15 -0.45 6.29e-18 Bipolar disorder and schizophrenia; CRC cis rs4076764 0.535 rs4409627 chr1:163382050 A/G cg24596788 chr1:163392923 NA 0.48 7.62 0.39 2.77e-13 Motion sickness; CRC cis rs6546324 0.580 rs1430785 chr2:67869292 A/G cg15745817 chr2:67799979 NA -0.45 -8.29 -0.42 2.86e-15 Endometriosis; CRC cis rs875971 0.862 rs13226170 chr7:65999298 G/A cg11764359 chr7:65958608 NA 0.59 8.86 0.44 5.17e-17 Aortic root size; CRC cis rs4555082 0.750 rs2816650 chr14:105708343 C/T cg10792982 chr14:105748885 BRF1 0.36 5.91 0.31 8.48e-9 Mean platelet volume;Platelet distribution width; CRC cis rs2832191 0.935 rs67287920 chr21:30523519 C/A cg08807101 chr21:30365312 RNF160 -0.59 -9.49 -0.46 4.91e-19 Dental caries; CRC cis rs4919694 1.000 rs17787717 chr10:104695699 T/G cg04362960 chr10:104952993 NT5C2 1.21 10.91 0.52 7.09e-24 Arsenic metabolism; CRC cis rs10479542 0.721 rs6894113 chr5:178974789 G/C cg00080972 chr5:178986291 RUFY1 0.38 7.07 0.36 9.07e-12 Lung cancer; CRC cis rs941873 0.803 rs5015119 chr10:81101609 G/C cg09469691 chr10:81107165 PPIF 0.51 7.93 0.4 3.37e-14 Height; CRC cis rs875971 0.825 rs1860472 chr7:66082723 T/C cg18876405 chr7:65276391 NA -0.54 -8.57 -0.43 4.17e-16 Aortic root size; CRC cis rs2535633 0.631 rs11915851 chr3:53096047 C/T cg15147215 chr3:52552868 STAB1 -0.39 -5.77 -0.3 1.81e-8 Body mass index; CRC cis rs7618501 0.633 rs3774733 chr3:50037123 C/G cg05623727 chr3:50126028 RBM5 0.46 7.69 0.39 1.76e-13 Intelligence (multi-trait analysis); CRC cis rs7591163 1.000 rs6744308 chr2:228711816 T/G cg21577049 chr2:228736449 WDR69 -0.47 -6.22 -0.32 1.5e-9 Blood pressure; CRC trans rs12699921 0.632 rs2723552 chr7:17860661 T/G cg02066331 chr6:17282778 RBM24 -0.36 -6.09 -0.32 3.23e-9 Fibrinogen levels; CRC trans rs2727020 0.567 rs1164687 chr11:49290669 G/A cg03929089 chr4:120376271 NA 0.67 9.35 0.46 1.35e-18 Coronary artery disease; CRC cis rs34172651 0.837 rs1978451 chr16:24818286 C/G cg00339695 chr16:24857497 SLC5A11 0.27 6.11 0.32 2.83e-9 Intelligence (multi-trait analysis); CRC cis rs951366 0.622 rs11580015 chr1:205676088 G/C cg24503407 chr1:205819492 PM20D1 0.81 11.98 0.55 1.08e-27 Menarche (age at onset); CRC cis rs4927850 1.000 rs7614767 chr3:195753451 C/T cg01181863 chr3:195395398 SDHAP2 -0.58 -8.07 -0.41 1.3e-14 Pancreatic cancer; CRC cis rs2213920 0.619 rs4979528 chr9:118194902 G/A cg13918206 chr9:118159781 DEC1 0.62 5.96 0.31 6.67e-9 Docetaxel-induced peripheral neuropathy in metastatic castrate-resistant prostate cancer; CRC cis rs2836950 0.502 rs12627205 chr21:40630027 C/T cg11890956 chr21:40555474 PSMG1 -0.64 -9.37 -0.46 1.21e-18 Menarche (age at onset); CRC cis rs10504229 0.683 rs72649187 chr8:58108320 A/G cg24829409 chr8:58192753 C8orf71 -0.56 -7.95 -0.4 3.02e-14 Developmental language disorder (linguistic errors); CRC trans rs1814175 0.791 rs11040513 chr11:49778153 G/C cg03929089 chr4:120376271 NA -0.97 -19.26 -0.73 6.71e-56 Height; CRC cis rs7640424 0.929 rs327139 chr3:107822481 G/C cg09227934 chr3:107805635 CD47 0.42 6.32 0.33 8.31e-10 Body mass index; CRC cis rs3857067 0.736 rs2865333 chr4:95019964 A/G cg11021082 chr4:95130006 SMARCAD1 -0.4 -6.05 -0.32 3.9e-9 QT interval; CRC cis rs9322193 0.923 rs11155677 chr6:150078089 C/G cg00933542 chr6:150070202 PCMT1 0.33 6.97 0.36 1.73e-11 Lung cancer; CRC cis rs9309473 0.583 rs11126397 chr2:73588733 C/T cg20560298 chr2:73613845 ALMS1 -0.49 -6.78 -0.35 5.69e-11 Metabolite levels; CRC cis rs9435341 0.965 rs55909997 chr1:107581039 G/A cg09367891 chr1:107599246 PRMT6 0.69 10.08 0.49 5.39e-21 Facial morphology (factor 21, depth of nasal alae); CRC cis rs801193 0.569 rs6978178 chr7:66123084 G/A cg00343986 chr7:65444356 GUSB -0.45 -6.21 -0.32 1.6e-9 Aortic root size; CRC cis rs7618915 0.547 rs6762813 chr3:52726695 C/T cg18099408 chr3:52552593 STAB1 -0.44 -7.26 -0.37 2.77e-12 Bipolar disorder; CRC trans rs2727020 0.857 rs1917324 chr11:49371759 G/C cg15704280 chr7:45808275 SEPT13 -0.77 -10.34 -0.5 7.21e-22 Coronary artery disease; CRC cis rs12983728 0.505 rs35511051 chr19:58665817 C/A cg08687515 chr19:58661962 ZNF329 0.48 5.97 0.31 6.07e-9 Cholesterol, total; CRC cis rs12900413 0.645 rs28507224 chr15:90305393 T/C cg24249390 chr15:90295951 MESP1 -0.56 -9.02 -0.45 1.59e-17 Coronary artery aneurysm in Kawasaki disease; CRC cis rs933688 1.000 rs332529 chr5:90789470 G/A cg02339078 chr5:90679543 LOC100129716;ARRDC3 0.83 12.84 0.58 7.28e-31 Smoking behavior; CRC cis rs9491140 0.514 rs11154227 chr6:124681816 G/A cg05308643 chr6:124982296 NKAIN2 0.45 5.91 0.31 8.78e-9 Neuroticism; CRC cis rs12451471 0.637 rs7567 chr17:78093549 G/T cg08347473 chr17:78092826 GAA -0.37 -5.97 -0.31 6.08e-9 Plateletcrit;Mean corpuscular hemoglobin concentration; CRC cis rs796364 0.951 rs35618222 chr2:201065777 C/G cg25936922 chr2:200820526 C2orf60;C2orf47 0.61 6.63 0.34 1.35e-10 Schizophrenia; CRC cis rs9527 0.501 rs12244388 chr10:104640052 G/A cg15744005 chr10:104629667 AS3MT -0.37 -7.68 -0.39 1.83e-13 Arsenic metabolism; CRC cis rs736408 0.660 rs2019065 chr3:52809525 C/T cg18404041 chr3:52824283 ITIH1 0.39 8.07 0.41 1.34e-14 Bipolar disorder; CRC cis rs1881797 0.932 rs10925071 chr1:247686521 C/T cg18198730 chr1:247681584 NA -0.6 -10.78 -0.51 2.04e-23 Acute lymphoblastic leukemia (childhood); CRC cis rs8058578 1.000 rs7204278 chr16:30730274 A/G cg05768032 chr16:30646687 NA 0.37 5.64 0.3 3.69e-8 Multiple myeloma; CRC cis rs9381040 0.701 rs4711658 chr6:41162891 C/T cg03644281 chr6:41068752 NFYA;LOC221442 0.41 6.06 0.32 3.74e-9 Alzheimer's disease (late onset); CRC cis rs929354 0.742 rs3808316 chr7:156944787 C/G cg17757837 chr7:157058334 UBE3C 0.73 12.11 0.56 3.71e-28 Body mass index; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg24418792 chr10:104153828 NFKB2 0.42 6.11 0.32 2.85e-9 Anxiety disorder; CRC cis rs11148252 0.634 rs66849828 chr13:52714837 C/A cg00495681 chr13:53174319 NA 0.54 7.93 0.4 3.54e-14 Lewy body disease; CRC cis rs9467711 0.606 rs68112369 chr6:26365759 T/C cg16898833 chr6:26189333 HIST1H4D 0.74 6.28 0.33 1.05e-9 Autism spectrum disorder or schizophrenia; CRC cis rs75920871 0.528 rs11216241 chr11:116899249 A/C cg01368799 chr11:117014884 PAFAH1B2 -0.41 -5.84 -0.31 1.26e-8 Subjective well-being; CRC cis rs1790761 0.692 rs10896179 chr11:67316928 C/A cg24690094 chr11:67383802 NA 0.34 6.14 0.32 2.33e-9 Mean corpuscular volume; CRC cis rs2688608 0.592 rs11000758 chr10:75493610 A/T cg16540259 chr10:75572220 NDST2 0.38 5.98 0.31 5.77e-9 Inflammatory bowel disease; CRC cis rs2439831 0.867 rs2447196 chr15:43893818 A/G cg02155558 chr15:43621948 ADAL;LCMT2 -0.65 -7.64 -0.39 2.35e-13 Lung cancer in ever smokers; CRC cis rs703842 1.000 rs3782130 chr12:58161898 G/C cg00677455 chr12:58241039 CTDSP2 0.66 9.07 0.45 1.14e-17 Multiple sclerosis; CRC cis rs8060686 0.641 rs55725810 chr16:68189636 C/T cg08314208 chr16:67682810 RLTPR -0.53 -5.73 -0.3 2.33e-8 HDL cholesterol;Metabolic syndrome; CRC cis rs10504229 1.000 rs56740825 chr8:58175617 A/G cg22535103 chr8:58192502 C8orf71 -0.82 -12.27 -0.56 9.63e-29 Developmental language disorder (linguistic errors); CRC cis rs7659604 0.539 rs11098645 chr4:122729251 G/A cg19748678 chr4:122722346 EXOSC9 0.66 10.24 0.49 1.49e-21 Type 2 diabetes; CRC cis rs9640161 0.750 rs4395803 chr7:150025367 A/C cg12556325 chr7:150026731 C7orf29;LRRC61 -0.45 -6.71 -0.35 8.31e-11 Blood protein levels;Circulating chemerin levels; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg08137080 chr1:16482430 EPHA2 0.34 6.44 0.33 4.29e-10 Liver disease severity in Alagille syndrome; CRC cis rs17095355 1.000 rs958086 chr10:111752548 G/T cg00817464 chr10:111662876 XPNPEP1 -0.58 -7.3 -0.37 2.17e-12 Biliary atresia; CRC cis rs9393777 0.513 rs3999471 chr6:26650306 T/C cg12292205 chr6:26970375 C6orf41 -0.61 -6.99 -0.36 1.52e-11 Intelligence (multi-trait analysis); CRC cis rs11628318 0.614 rs62007925 chr14:103128288 G/A cg23071808 chr14:103021642 NA 0.62 6.96 0.36 1.82e-11 Platelet count; CRC trans rs2727020 0.704 rs4144700 chr11:49370834 C/A cg03929089 chr4:120376271 NA -0.83 -14.65 -0.63 9.06e-38 Coronary artery disease; CRC cis rs2072499 0.966 rs2842869 chr1:156160696 A/G cg25208724 chr1:156163844 SLC25A44 1.1 26.81 0.83 9.1200000000000006e-85 Testicular germ cell tumor; CRC cis rs589448 0.900 rs588493 chr12:69751986 G/A cg22834771 chr12:69754056 YEATS4 -0.56 -8.73 -0.43 1.33e-16 Cerebrospinal fluid biomarker levels; CRC cis rs1448094 0.511 rs11117042 chr12:86207547 G/T cg18827107 chr12:86230957 RASSF9 -0.37 -6.01 -0.31 5.05e-9 Major depressive disorder; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg05542295 chr17:55162876 AKAP1 0.44 6.23 0.32 1.4e-9 Response to antipsychotic treatment; CRC cis rs873946 0.648 rs1548281 chr10:134552982 C/T cg27286337 chr10:134555280 INPP5A 0.78 9.43 0.46 7.54e-19 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CRC cis rs911555 0.755 rs1138400 chr14:103956833 A/G cg24130564 chr14:104152367 KLC1 -0.41 -5.72 -0.3 2.43e-8 Intelligence (multi-trait analysis); CRC cis rs911555 0.723 rs2273701 chr14:103923225 G/T cg12935359 chr14:103987150 CKB 0.56 9.01 0.44 1.77e-17 Intelligence (multi-trait analysis); CRC cis rs9902453 0.934 rs7211246 chr17:28485762 A/G cg26525008 chr17:28256777 EFCAB5;SSH2 0.6 9.49 0.46 5.04e-19 Coffee consumption (cups per day); CRC trans rs10982213 0.830 rs2274163 chr9:117188714 C/T cg10922530 chr12:124457083 CCDC92;ZNF664 0.38 6.84 0.35 3.76e-11 Interleukin-6 levels; CRC trans rs800082 0.646 rs2717394 chr3:144280612 A/T cg24215973 chr2:240111563 HDAC4 0.57 8.87 0.44 4.89e-17 Smoking behavior; CRC cis rs10876993 0.928 rs1678530 chr12:58054076 A/C cg18357645 chr12:58087776 OS9 0.56 7.61 0.39 3e-13 Celiac disease or Rheumatoid arthritis; CRC cis rs2274273 0.840 rs7153110 chr14:55820628 A/G cg23234261 chr14:55582407 NA -0.29 -5.84 -0.31 1.24e-8 Protein biomarker; CRC cis rs28386778 0.897 rs2665796 chr17:61923716 G/C cg06873352 chr17:61820015 STRADA 0.76 14.24 0.62 3.62e-36 Prudent dietary pattern; CRC cis rs644799 0.965 rs687529 chr11:95545587 T/A cg25478527 chr11:95522999 CEP57;FAM76B 0.51 7.69 0.39 1.68e-13 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs6860806 0.661 rs4705929 chr5:131584178 G/T cg02033258 chr5:131593261 PDLIM4 0.4 7.71 0.39 1.48e-13 Breast cancer; CRC cis rs8177253 0.930 rs12595 chr3:133496553 T/C cg11941060 chr3:133502564 NA -0.59 -10.14 -0.49 3.4e-21 Iron status biomarkers; CRC cis rs10504229 0.724 rs72650827 chr8:58126884 A/T cg02290350 chr8:58132656 NA -0.58 -8.16 -0.41 7.29e-15 Developmental language disorder (linguistic errors); CRC cis rs12190007 0.512 rs2984464 chr6:169837242 T/C cg15038512 chr6:170123185 PHF10 -0.4 -6.15 -0.32 2.28e-9 Obesity-related traits; CRC cis rs56114371 0.530 rs9348774 chr6:27688930 C/T cg03623178 chr6:28175578 NA 0.5 6.01 0.31 4.82e-9 Breast cancer; CRC cis rs10504229 0.683 rs10504223 chr8:58140944 G/A cg05313129 chr8:58192883 C8orf71 -0.43 -6.11 -0.32 2.74e-9 Developmental language disorder (linguistic errors); CRC cis rs4853012 0.838 rs4429500 chr2:74345336 A/G cg19729930 chr2:74357872 NA 0.58 9.12 0.45 7.56e-18 Gestational age at birth (maternal effect); CRC cis rs4363385 0.693 rs310102 chr1:153042423 T/C cg25856811 chr1:152973957 SPRR3 -0.24 -6.58 -0.34 1.84e-10 Inflammatory skin disease; CRC cis rs597539 0.690 rs578791 chr11:68625809 C/T cg21963583 chr11:68658836 MRPL21 0.59 10.38 0.5 5.06e-22 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs4727027 0.933 rs28767030 chr7:148825918 T/G cg12479418 chr7:148823350 ZNF425;ZNF398 0.41 5.61 0.3 4.31e-8 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC cis rs2836974 0.590 rs9974757 chr21:40617244 T/C cg17971929 chr21:40555470 PSMG1 -0.72 -11.09 -0.52 1.7e-24 Cognitive function; CRC cis rs1448094 0.549 rs57614821 chr12:86235361 A/C cg25456477 chr12:86230367 RASSF9 0.36 6.24 0.33 1.37e-9 Major depressive disorder; CRC cis rs4332037 0.539 rs55993248 chr7:2071132 A/G cg13880726 chr7:1868755 MAD1L1 -0.46 -5.72 -0.3 2.42e-8 Bipolar disorder; CRC cis rs2760061 0.598 rs2796056 chr1:228122901 G/A cg18477163 chr1:228402036 OBSCN -0.34 -5.62 -0.3 4.14e-8 Diastolic blood pressure; CRC cis rs7727544 0.716 rs11955347 chr5:131567924 G/A cg04518342 chr5:131593106 PDLIM4 0.38 6.97 0.36 1.78e-11 Blood metabolite levels; CRC cis rs501120 0.584 rs1704223 chr10:44677014 C/T cg09554077 chr10:44749378 NA 0.7 7.85 0.4 5.95e-14 Coronary artery disease;Coronary heart disease; CRC cis rs1682361 1 rs1682361 chr3:136734014 G/C cg21827317 chr3:136751795 NA 0.52 8.62 0.43 2.94e-16 Schizophrenia; CRC cis rs13064411 0.735 rs722392 chr3:113228294 A/G cg18753928 chr3:113234510 CCDC52 -0.69 -10.6 -0.5 9.1e-23 Response to simvastatin treatment (PCSK9 protein level change); CRC cis rs4555082 0.874 rs2015978 chr14:105720134 G/C cg10792982 chr14:105748885 BRF1 0.39 6.57 0.34 2.03e-10 Mean platelet volume;Platelet distribution width; CRC cis rs2742417 0.603 rs1962800 chr3:45779943 C/T cg10512202 chr3:45649293 LIMD1 0.4 5.66 0.3 3.33e-8 Response to anti-depressant treatment in major depressive disorder; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg16143763 chr17:41116517 AARSD1 0.38 6.56 0.34 2.11e-10 Liver disease severity in Alagille syndrome; CRC trans rs2243480 1.000 rs6964245 chr7:65718717 G/A cg10756647 chr7:56101905 PSPH -0.78 -8.04 -0.41 1.65e-14 Diabetic kidney disease; CRC cis rs62244186 0.659 rs62251383 chr3:44552421 A/G cg10263370 chr3:44754102 ZNF502 -0.36 -5.98 -0.31 5.85e-9 Depressive symptoms; CRC cis rs4665809 1.000 rs6546744 chr2:26302161 A/G cg04944784 chr2:26401820 FAM59B -0.6 -7.75 -0.39 1.17e-13 Gut microbiome composition (summer); CRC trans rs4263408 0.934 rs9683743 chr4:39703194 A/C cg00844328 chr13:33002010 N4BP2L1 -0.42 -6.1 -0.32 2.95e-9 Plasma amyloid beta peptide concentrations (ABx-40); CRC cis rs892961 1.000 rs892961 chr17:75400100 A/T cg05865280 chr17:75406074 SEPT9 0.59 8.44 0.42 1.03e-15 Airflow obstruction; CRC cis rs10493773 0.532 rs1889919 chr1:86180034 A/G cg17807903 chr1:86174739 ZNHIT6 -0.56 -15.1 -0.64 1.73e-39 Urate levels in overweight individuals; CRC cis rs2929278 0.588 rs1975364 chr15:44150189 A/G cg02155558 chr15:43621948 ADAL;LCMT2 0.48 6.81 0.35 4.76e-11 Schizophrenia; CRC cis rs2032447 1.000 rs2032447 chr6:26044369 A/G cg27635394 chr6:26043820 HIST1H2BB 0.4 6.06 0.32 3.67e-9 Intelligence (multi-trait analysis); CRC cis rs780096 0.526 rs11127013 chr2:27692973 A/G cg21248554 chr2:27665150 KRTCAP3 -0.33 -7.3 -0.37 2.24e-12 Total body bone mineral density; CRC cis rs7131987 0.903 rs7308125 chr12:29425211 T/C cg09582351 chr12:29534625 ERGIC2 -0.34 -7.27 -0.37 2.69e-12 QT interval; CRC cis rs13108904 0.967 rs13109112 chr4:1290481 C/A cg02018176 chr4:1364513 KIAA1530 0.47 7.66 0.39 2.07e-13 Obesity-related traits; CRC cis rs11146838 1 rs11146838 chr10:39149977 A/T cg17219203 chr10:38645113 HSD17B7P2 -0.45 -6.42 -0.33 4.64e-10 Breast cancer; CRC cis rs2361718 0.501 rs8065486 chr17:78138196 A/G cg20811857 chr17:78079795 GAA 0.49 6.88 0.35 3.04e-11 Yeast infection; CRC cis rs4665809 1.000 rs1550382 chr2:26266877 T/G cg04944784 chr2:26401820 FAM59B -0.6 -7.72 -0.39 1.38e-13 Gut microbiome composition (summer); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg11970301 chr16:30087888 PPP4C 0.47 6.7 0.35 9.09e-11 Response to antipsychotic treatment; CRC cis rs8062405 0.755 rs56209193 chr16:28585636 C/T cg05139728 chr16:28306816 SBK1 -0.39 -6.22 -0.32 1.47e-9 Cognitive ability (multi-trait analysis);Cognitive ability; CRC cis rs6540556 0.723 rs11119327 chr1:209883804 T/C cg05527609 chr1:210001259 C1orf107 -0.53 -5.62 -0.3 4.17e-8 Red blood cell count; CRC cis rs12477438 0.798 rs6736064 chr2:99658201 G/A cg14399236 chr2:99771627 LIPT1;TSGA10 -0.74 -10.37 -0.5 5.51e-22 Chronic sinus infection; CRC cis rs295140 0.546 rs295119 chr2:201117944 C/T cg23649088 chr2:200775458 C2orf69 0.42 5.97 0.31 6.06e-9 QT interval; CRC cis rs11628318 0.614 rs72635192 chr14:103128646 C/T cg23071808 chr14:103021642 NA 0.62 6.96 0.36 1.82e-11 Platelet count; CRC cis rs60780116 1 rs60780116 chr4:185708807 T/C cg04058563 chr4:185651563 MLF1IP 0.58 6.19 0.32 1.74e-9 Type 2 diabetes; CRC cis rs76878669 0.538 rs4930360 chr11:66143247 T/A cg18002602 chr11:66138449 SLC29A2 0.29 6.19 0.32 1.84e-9 Educational attainment (years of education); CRC cis rs3858526 0.584 rs10769266 chr11:5858460 C/T cg05234568 chr11:5960015 NA -0.63 -8.87 -0.44 4.85e-17 DNA methylation (variation); CRC cis rs174601 0.864 rs174545 chr11:61569306 C/G cg00603274 chr11:61596626 FADS2 -0.44 -6.4 -0.33 5.33e-10 Blood metabolite levels;Red blood cell fatty acid levels;Liver enzyme levels (alkaline phosphatase);Gondoic acid (20:1n-9) levels;Trans fatty acid levels; CRC cis rs7945705 0.837 rs10769966 chr11:8847041 C/A cg14711859 chr11:8959438 ASCL3 -0.48 -8.18 -0.41 6.46e-15 Hemoglobin concentration; CRC cis rs62064224 0.614 rs4795700 chr17:30763794 A/G cg09324608 chr17:30823087 MYO1D 0.35 5.96 0.31 6.64e-9 Schizophrenia; CRC trans rs3774749 0.565 rs2518796 chr3:50207075 A/G cg21659725 chr3:3221576 CRBN 0.43 6.33 0.33 8.03e-10 Intelligence (multi-trait analysis); CRC cis rs2762353 0.524 rs9467596 chr6:25783022 A/G cg17691542 chr6:26056736 HIST1H1C -0.49 -7.03 -0.36 1.19e-11 Blood metabolite levels; CRC cis rs6460942 0.778 rs74993124 chr7:12462917 A/G cg20607287 chr7:12443886 VWDE -0.59 -7.37 -0.38 1.4e-12 Coronary artery disease; CRC cis rs7113874 0.610 rs11041924 chr11:8463107 C/T cg02811074 chr11:8615871 STK33 -0.36 -6.23 -0.32 1.45e-9 Body mass index in physically active individuals;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs13118159 0.550 rs10016557 chr4:1363628 C/T cg20887711 chr4:1340912 KIAA1530 -0.73 -10.54 -0.5 1.38e-22 Longevity; CRC cis rs11212617 0.967 rs634268 chr11:108186258 G/A cg01991180 chr11:108092276 ATM;NPAT 0.41 5.86 0.31 1.12e-8 Response to metformin in type 2 diabetes (glycemic); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg19586645 chr17:73266642 MIF4GD 0.43 6.51 0.34 2.87e-10 Intelligence (multi-trait analysis); CRC cis rs4727027 0.800 rs10952796 chr7:148813138 G/C cg12479418 chr7:148823350 ZNF425;ZNF398 0.43 5.88 0.31 1.01e-8 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC cis rs1150668 0.835 rs1233696 chr6:28143010 T/C cg06470822 chr6:28175283 NA 0.66 10.08 0.49 5.48e-21 Pubertal anthropometrics; CRC cis rs55702914 0.742 rs34555121 chr2:198166053 C/T cg20885578 chr2:198174922 NA 0.35 6.06 0.32 3.7e-9 Major depression and alcohol dependence; CRC cis rs1997103 0.954 rs7811098 chr7:55413012 A/G cg17469321 chr7:55412551 NA 0.74 11.73 0.54 8.89e-27 QRS interval (sulfonylurea treatment interaction); CRC cis rs7618915 0.571 rs6798246 chr3:52599922 G/A cg05573699 chr3:52720067 GNL3;PBRM1 -0.44 -6.23 -0.32 1.44e-9 Bipolar disorder; CRC cis rs11203032 0.831 rs10509567 chr10:90945756 G/A cg16672925 chr10:90967113 CH25H 0.45 5.63 0.3 3.93e-8 Heart failure; CRC cis rs225245 0.817 rs225290 chr17:33927904 C/G cg05299278 chr17:33885742 SLFN14 0.49 8.04 0.41 1.6e-14 Reticulocyte count;Reticulocyte fraction of red cells;High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells; CRC cis rs9916302 0.904 rs755500 chr17:37409865 C/T cg00129232 chr17:37814104 STARD3 -0.52 -7.64 -0.39 2.45e-13 Glomerular filtration rate (creatinine); CRC cis rs11971779 0.680 rs73154134 chr7:139039951 G/A cg07862535 chr7:139043722 LUC7L2 0.78 9.84 0.48 3.36e-20 Diisocyanate-induced asthma; CRC cis rs9902453 0.817 rs62068620 chr17:28167674 A/T cg26525008 chr17:28256777 EFCAB5;SSH2 0.57 8.63 0.43 2.59e-16 Coffee consumption (cups per day); CRC cis rs2836974 0.932 rs2150415 chr21:40615367 A/G cg11644478 chr21:40555479 PSMG1 0.79 11.95 0.55 1.41e-27 Cognitive function; CRC cis rs7811142 0.830 rs73401450 chr7:99981859 G/C cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.74 9.91 0.48 1.93e-20 Platelet count; CRC cis rs3736594 0.513 rs56725354 chr2:27824168 G/C cg27432699 chr2:27873401 GPN1 0.65 8.29 0.42 2.95e-15 Fasting blood glucose;Fasting blood glucose (BMI interaction); CRC cis rs11148252 0.712 rs61957257 chr13:52769702 G/A cg00495681 chr13:53174319 NA 0.63 9.88 0.48 2.53e-20 Lewy body disease; CRC trans rs10435719 0.899 rs11250177 chr8:11799099 G/A cg06636001 chr8:8085503 FLJ10661 0.49 7.25 0.37 2.92e-12 C-reactive protein levels or triglyceride levels (pleiotropy); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg04139749 chr14:77786727 GSTZ1;POMT2 0.4 6.36 0.33 6.68e-10 Liver disease severity in Alagille syndrome; CRC cis rs1862618 0.526 rs2591963 chr5:56237135 T/A cg20203395 chr5:56204925 C5orf35 0.8 9.74 0.47 7.54e-20 Initial pursuit acceleration; CRC cis rs12369179 1.000 rs12369179 chr12:122963550 C/T cg18578876 chr12:123200353 GPR109B -1.14 -9.02 -0.45 1.57e-17 Age-related diseases, mortality and associated endophenotypes;Age-related disease endophenotypes; CRC cis rs4713118 0.527 rs35949862 chr6:28115367 A/G cg02631126 chr6:28058918 ZSCAN12L1 0.29 5.91 0.31 8.38e-9 Parkinson's disease; CRC cis rs6495122 0.501 rs8039755 chr15:75337426 T/C cg18612461 chr15:75251733 NA -0.37 -5.64 -0.3 3.57e-8 Caffeine consumption;Diastolic blood pressure;Coffee consumption; CRC cis rs6662572 1.000 rs72688469 chr1:46118393 T/A cg08644498 chr1:46502608 NA 0.47 6.89 0.35 2.93e-11 Blood protein levels; CRC cis rs10540 1.000 rs12801271 chr11:508720 C/T cg08200582 chr11:442649 ANO9 -0.71 -7.39 -0.38 1.2e-12 Body mass index; CRC cis rs7666738 0.830 rs28818180 chr4:98953625 A/G cg05340658 chr4:99064831 C4orf37 0.61 9.54 0.47 3.45e-19 Colonoscopy-negative controls vs population controls; CRC cis rs1691799 0.899 rs903587 chr12:66746061 C/A cg16791601 chr12:66731901 HELB -0.73 -12.99 -0.58 1.9e-31 White blood cell count (basophil); CRC cis rs2243480 1.000 rs1404147 chr7:65264524 C/T cg25985355 chr7:65971099 NA -0.46 -5.98 -0.31 5.85e-9 Diabetic kidney disease; CRC cis rs6952808 0.689 rs2008263 chr7:2048335 A/G cg00106254 chr7:1943704 MAD1L1 -0.47 -6.96 -0.36 1.89e-11 Bipolar disorder and schizophrenia; CRC cis rs9462027 0.628 rs9462009 chr6:34716330 G/A cg07306190 chr6:34760872 UHRF1BP1 -0.35 -6.24 -0.33 1.36e-9 Systemic lupus erythematosus; CRC cis rs972578 0.837 rs6002963 chr22:43246146 C/T cg01576275 chr22:43409880 NA -0.41 -6.32 -0.33 8.72e-10 Mean platelet volume; CRC cis rs2019137 0.868 rs6755639 chr2:113981810 A/G cg21550016 chr2:113992930 PAX8;LOC440839;LOC654433 0.51 7.36 0.38 1.52e-12 Lymphocyte counts; CRC trans rs7395662 0.963 rs11040172 chr11:48968497 A/T cg21153622 chr11:89784906 NA -0.48 -7.62 -0.39 2.78e-13 HDL cholesterol; CRC cis rs13256369 1.000 rs10088439 chr8:8576699 T/G cg06671706 chr8:8559999 CLDN23 0.57 8.35 0.42 1.95e-15 Obesity-related traits; CRC cis rs6445967 1.000 rs12633655 chr3:58306321 T/C cg23715586 chr3:58305044 RPP14 0.34 5.72 0.3 2.45e-8 Platelet count; CRC cis rs9910055 0.529 rs228765 chr17:42186422 C/T cg09913183 chr17:42254507 C17orf65;ASB16 -0.49 -6.76 -0.35 6.31e-11 Total body bone mineral density; CRC trans rs11039798 0.925 rs12277669 chr11:48925316 A/T cg03929089 chr4:120376271 NA 0.64 6.1 0.32 2.95e-9 Axial length; CRC cis rs12580194 0.593 rs61957941 chr12:55748058 G/A cg23425280 chr12:56401806 NA 0.47 5.72 0.3 2.44e-8 Cancer; CRC cis rs9811920 0.609 rs6809988 chr3:99656615 A/G cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G -0.46 -6.16 -0.32 2.07e-9 Axial length; CRC cis rs9796 0.663 rs11853192 chr15:41368515 G/A cg18705301 chr15:41695430 NDUFAF1 -0.42 -6.92 -0.36 2.4e-11 Menopause (age at onset); CRC cis rs7914558 0.966 rs7908280 chr10:104816947 C/G cg15744005 chr10:104629667 AS3MT -0.34 -7.19 -0.37 4.36e-12 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs1348850 0.914 rs12693120 chr2:178283288 A/G cg22681709 chr2:178499509 PDE11A -0.4 -7.37 -0.38 1.41e-12 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs6598955 0.666 rs12759434 chr1:26607123 C/T cg04990556 chr1:26633338 UBXN11 -0.78 -13.01 -0.58 1.61e-31 Obesity-related traits; CRC cis rs12450688 1 rs12450688 chr17:38144229 G/A cg17467752 chr17:38218738 THRA -0.56 -8.93 -0.44 2.99e-17 Sum eosinophil basophil counts; CRC cis rs754466 0.651 rs11818687 chr10:79637709 C/T cg17075019 chr10:79541650 NA -0.88 -15.23 -0.64 4.95e-40 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs736801 0.740 rs17622378 chr5:131778452 A/G cg14196790 chr5:131705035 SLC22A5 0.35 5.73 0.3 2.25e-8 Breast cancer;Mosquito bite size; CRC cis rs4481887 0.927 rs12044126 chr1:248481952 T/C cg13385794 chr1:248469461 NA 0.38 6.68 0.35 1.01e-10 Common traits (Other); CRC cis rs7428 0.502 rs3184781 chr2:85549527 T/C cg24342717 chr2:85555507 TGOLN2 -0.72 -11.94 -0.55 1.5e-27 Ear protrusion; CRC cis rs9326248 1.000 rs664082 chr11:117071070 C/G cg26566898 chr11:117069891 TAGLN 0.45 9.65 0.47 1.49e-19 Blood protein levels; CRC cis rs972578 1.000 rs4140554 chr22:43355256 A/G cg01576275 chr22:43409880 NA 0.44 7.03 0.36 1.21e-11 Mean platelet volume; CRC cis rs2549003 1.000 rs9282763 chr5:131822133 T/C cg21138405 chr5:131827807 IRF1 0.57 11.38 0.53 1.59e-25 Asthma (sex interaction); CRC cis rs1059312 0.808 rs11059921 chr12:129289919 C/T cg04043695 chr12:129287642 SLC15A4 0.38 5.74 0.3 2.21e-8 Systemic lupus erythematosus; CRC cis rs6763159 0.967 rs11130727 chr3:59642877 T/C cg07069742 chr3:59644285 NA -0.33 -6.57 -0.34 2.01e-10 Conotruncal heart defects; CRC cis rs12681287 0.640 rs12550142 chr8:87471861 C/A cg27223183 chr8:87520930 FAM82B -0.52 -7.47 -0.38 7.07e-13 Caudate activity during reward; CRC cis rs11098499 0.954 rs6822679 chr4:120402702 A/C cg09307838 chr4:120376055 NA 0.7 10.95 0.52 5.46e-24 Corneal astigmatism; CRC cis rs10503871 0.594 rs10954994 chr8:30306419 C/A cg26383811 chr8:30366931 RBPMS 0.48 7.61 0.39 2.96e-13 Metabolite levels (X-11787); CRC cis rs2806561 0.765 rs641032 chr1:23513980 C/T cg12483005 chr1:23474871 LUZP1 -0.48 -6.99 -0.36 1.52e-11 Height; CRC cis rs79057730 0.599 rs4721086 chr7:821123 G/A cg06242242 chr7:766104 PRKAR1B;HEATR2 0.54 5.62 0.3 4.14e-8 Initial pursuit acceleration; CRC cis rs910316 0.935 rs175076 chr14:75505486 A/G cg11812906 chr14:75593930 NEK9 -0.62 -10.09 -0.49 4.84e-21 Height; CRC cis rs6088590 1.000 rs6087632 chr20:33407704 A/C cg24642439 chr20:33292090 TP53INP2 0.59 10.57 0.5 1.15e-22 Coronary artery disease; CRC trans rs9858542 1.000 rs4283605 chr3:49678651 A/G cg21659725 chr3:3221576 CRBN -0.72 -9.6 -0.47 2.08e-19 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs7020830 0.867 rs56098516 chr9:37362220 A/G cg14294708 chr9:37120828 ZCCHC7 1.19 27.0 0.83 1.83e-85 Schizophrenia; CRC cis rs11212617 1.000 rs227087 chr11:108244114 T/C cg01991180 chr11:108092276 ATM;NPAT 0.44 6.62 0.34 1.5e-10 Response to metformin in type 2 diabetes (glycemic); CRC cis rs1448094 0.510 rs1993806 chr12:86147151 T/C cg18827107 chr12:86230957 RASSF9 0.39 5.96 0.31 6.52e-9 Major depressive disorder; CRC cis rs10540 1.000 rs35068485 chr11:466032 A/T cg21784768 chr11:537496 LRRC56 -0.59 -5.64 -0.3 3.67e-8 Body mass index; CRC cis rs13108904 0.967 rs62293658 chr4:1276416 T/C cg15763984 chr4:1342303 KIAA1530 -0.35 -6.13 -0.32 2.5e-9 Obesity-related traits; CRC cis rs10504229 1.000 rs67188507 chr8:58187492 A/T cg02725872 chr8:58115012 NA -0.38 -6.43 -0.33 4.44e-10 Developmental language disorder (linguistic errors); CRC cis rs2376015 1 rs2376015 chr1:66123774 A/G cg04111102 chr1:66153794 NA 0.34 5.96 0.31 6.52e-9 Fibrinogen levels; CRC cis rs6961069 0.749 rs4316098 chr7:80259988 C/T cg04458919 chr7:80252533 CD36 0.34 5.98 0.31 5.72e-9 Platelet count; CRC cis rs8103278 0.507 rs2041975 chr19:46238555 T/C cg11657440 chr19:46296263 DMWD 0.71 11.89 0.55 2.39e-27 Coronary artery disease; CRC cis rs6089584 0.853 rs1746280 chr20:60577821 C/G cg23262073 chr20:60523788 NA -0.5 -7.74 -0.39 1.24e-13 Body mass index; CRC cis rs7552404 0.690 rs2029681 chr1:76333846 G/A cg22875332 chr1:76189707 ACADM -0.55 -7.17 -0.37 4.89e-12 Blood metabolite levels;Acylcarnitine levels; CRC cis rs2882667 0.690 rs9942422 chr5:138272536 A/G cg09476006 chr5:138032270 NA 0.6 10.13 0.49 3.64e-21 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs10479542 0.784 rs4701132 chr5:178985270 A/G cg26516362 chr5:178986906 RUFY1 -0.4 -7.54 -0.38 4.58e-13 Lung cancer; CRC cis rs7312933 0.703 rs10880268 chr12:42599122 C/T cg11827402 chr12:42719852 PPHLN1;ZCRB1 0.65 9.07 0.45 1.14e-17 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CRC cis rs9398803 0.830 rs4053271 chr6:126830512 T/C cg19875578 chr6:126661172 C6orf173 0.42 5.86 0.31 1.15e-8 Male-pattern baldness; CRC cis rs7917772 0.582 rs12411442 chr10:104349531 A/G cg11453585 chr10:104263688 ACTR1A;SUFU 0.82 15.29 0.64 3.08e-40 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC trans rs7267979 0.966 rs2261747 chr20:25261784 G/A cg17903999 chr18:56338584 MALT1 -0.41 -6.67 -0.35 1.06e-10 Liver enzyme levels (alkaline phosphatase); CRC cis rs875971 0.660 rs28698552 chr7:66005018 A/G cg00343986 chr7:65444356 GUSB 0.49 7.42 0.38 1e-12 Aortic root size; CRC cis rs796364 0.760 rs1569178 chr2:201024512 T/C cg25936922 chr2:200820526 C2orf60;C2orf47 -0.64 -5.81 -0.31 1.48e-8 Schizophrenia; CRC cis rs9517313 0.551 rs2274051 chr13:99091634 A/G cg07423050 chr13:99094983 FARP1 0.6 8.86 0.44 5.19e-17 Neuroticism; CRC cis rs72781680 0.752 rs72796114 chr2:23906133 C/G cg08917208 chr2:24149416 ATAD2B 1.02 9.32 0.46 1.8e-18 Lymphocyte counts; CRC cis rs501120 0.810 rs473501 chr10:44749171 G/A cg09554077 chr10:44749378 NA 0.9 13.3 0.59 1.4e-32 Coronary artery disease;Coronary heart disease; CRC cis rs28386778 0.897 rs1470697 chr17:61799840 T/C cg22520471 chr17:61851767 DDX42;CCDC47 0.73 11.17 0.52 9.08e-25 Prudent dietary pattern; CRC cis rs477895 0.713 rs2282490 chr11:63962152 T/C cg23719950 chr11:63933701 MACROD1 -0.67 -8.63 -0.43 2.76e-16 Mean platelet volume; CRC cis rs7089973 0.604 rs11196936 chr10:116588630 C/T cg23260525 chr10:116636907 FAM160B1 0.35 8.07 0.41 1.34e-14 Bipolar disorder or attention deficit hyperactivity disorder; CRC cis rs7811142 1.000 rs11773661 chr7:100073069 G/C cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.16 16.77 0.68 4.56e-46 Platelet count; CRC trans rs10842750 1.000 rs10842750 chr12:26690565 G/T cg10099229 chr12:6960622 USP5;CDCA3 0.51 6.02 0.31 4.7e-9 Kashin-Beck disease; CRC cis rs7659604 0.702 rs6826506 chr4:122710865 T/G cg06713675 chr4:122721982 EXOSC9 -0.5 -7.94 -0.4 3.19e-14 Type 2 diabetes; CRC cis rs6696846 0.740 rs11240369 chr1:205115099 G/A cg03948781 chr1:205179583 DSTYK 0.41 5.77 0.3 1.88e-8 Red blood cell count; CRC cis rs2976388 0.609 rs2585140 chr8:143806896 A/G cg12516270 chr8:143859308 LYNX1 0.43 7.57 0.39 3.83e-13 Urinary tract infection frequency; CRC cis rs6901250 0.851 rs607372 chr6:117155929 A/G cg12892004 chr6:117198278 RFX6 -0.43 -6.73 -0.35 7.45e-11 C-reactive protein levels; CRC cis rs6461049 0.765 rs10224497 chr7:2149967 A/G cg22963979 chr7:1858916 MAD1L1 -0.38 -5.96 -0.31 6.67e-9 Schizophrenia; CRC trans rs9291683 0.546 rs13129453 chr4:10044784 T/C cg26043149 chr18:55253948 FECH 0.51 7.63 0.39 2.62e-13 Bone mineral density; CRC cis rs7917772 0.503 rs2031601 chr10:104308064 T/G cg04362960 chr10:104952993 NT5C2 -0.41 -5.94 -0.31 7.31e-9 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC cis rs1005277 0.579 rs2474568 chr10:38383147 A/T cg25517755 chr10:38738941 LOC399744 -0.43 -6.2 -0.32 1.68e-9 Extrinsic epigenetic age acceleration; CRC cis rs7811142 1.000 rs60257855 chr7:100026780 G/C cg00814883 chr7:100076585 TSC22D4 -0.75 -9.55 -0.47 3.16e-19 Platelet count; CRC cis rs12681288 0.676 rs4565481 chr8:1001944 C/T cg04851639 chr8:1020857 NA -0.41 -8.12 -0.41 9.75e-15 Schizophrenia; CRC cis rs2108225 0.934 rs2301989 chr7:107443871 G/A cg18560240 chr7:107437656 SLC26A3 -0.57 -8.55 -0.43 4.81e-16 Ulcerative colitis; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg05943731 chr12:123444284 ABCB9 -0.35 -6.08 -0.32 3.37e-9 Liver disease severity in Alagille syndrome; CRC cis rs992157 1.000 rs2168704 chr2:219142492 G/A cg20019365 chr2:219134978 PNKD;AAMP 0.39 5.95 0.31 7.02e-9 Colorectal cancer; CRC cis rs7945705 0.905 rs7947631 chr11:8844909 A/G cg14711859 chr11:8959438 ASCL3 0.48 8.01 0.4 2.06e-14 Hemoglobin concentration; CRC cis rs6570726 0.791 rs9390336 chr6:145896823 A/T cg13319975 chr6:146136371 FBXO30 -0.42 -6.19 -0.32 1.75e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs7617773 0.963 rs9822496 chr3:48181333 T/C cg11946769 chr3:48343235 NME6 0.45 6.23 0.32 1.46e-9 Coronary artery disease; CRC cis rs1862618 0.853 rs6450409 chr5:56101399 A/G cg18230493 chr5:56204884 C5orf35 -0.7 -9.1 -0.45 9.03e-18 Initial pursuit acceleration; CRC cis rs800160 0.720 rs2106604 chr11:2341157 G/C cg09785033 chr11:2336066 TSPAN32 -0.5 -5.78 -0.3 1.7e-8 Bacteremia; CRC cis rs9457247 0.935 rs1794697 chr6:167395410 C/T cg23791538 chr6:167370224 RNASET2 -0.38 -5.97 -0.31 6.14e-9 Crohn's disease; CRC cis rs2070488 0.775 rs2051214 chr3:38560303 C/A cg01465620 chr3:38496096 LOC100128640;ACVR2B -0.65 -10.77 -0.51 2.32e-23 Electrocardiographic conduction measures; CRC cis rs10504229 1.000 rs17216620 chr8:58169412 A/G cg01721255 chr8:58191610 C8orf71 0.47 5.97 0.31 6.02e-9 Developmental language disorder (linguistic errors); CRC cis rs72781680 1.000 rs6710426 chr2:24159288 A/G cg08917208 chr2:24149416 ATAD2B 0.91 9.24 0.45 3.06e-18 Lymphocyte counts; CRC cis rs2880765 0.743 rs8039049 chr15:86007629 A/G cg17133734 chr15:86042851 AKAP13 0.4 6.33 0.33 8.2e-10 Coronary artery disease; CRC cis rs35883536 0.647 rs17402630 chr1:101046587 C/T cg06223162 chr1:101003688 GPR88 -0.34 -6.14 -0.32 2.43e-9 Monocyte count; CRC cis rs4737010 0.501 rs990174 chr8:41632230 A/G cg17182837 chr8:41585554 ANK1 -0.61 -8.67 -0.43 2.01e-16 Lymphocyte counts;High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Reticulocyte count;Reticulocyte fraction of red cells;Mean corpuscular volume;Immature fraction of reticulocytes;Mean corpuscular hemoglobin concentration; CRC cis rs1552244 0.832 rs73024591 chr3:10203194 A/T cg08888203 chr3:10149979 C3orf24 0.61 7.06 0.36 1.02e-11 Alzheimer's disease; CRC cis rs4665809 0.877 rs34536218 chr2:26287376 T/A cg27170947 chr2:26402098 FAM59B 0.49 5.79 0.3 1.61e-8 Gut microbiome composition (summer); CRC cis rs977987 0.806 rs6564258 chr16:75447363 G/A cg03315344 chr16:75512273 CHST6 0.54 9.08 0.45 1.04e-17 Dupuytren's disease; CRC cis rs6988985 0.818 rs3802228 chr8:143992218 A/G cg10324643 chr8:143916377 GML 0.4 6.72 0.35 8.24e-11 Plasma androstenedione levels in resected early stage-receptor positive breast cancer; CRC cis rs1799949 0.965 rs11080034 chr17:41443014 T/C cg23758822 chr17:41437982 NA 0.91 17.53 0.69 4.84e-49 Menopause (age at onset); CRC cis rs4713118 0.662 rs9380046 chr6:28030499 T/C cg12172441 chr6:28176163 NA 0.55 6.95 0.36 1.97e-11 Parkinson's disease; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg10137990 chr8:145137203 GPAA1 0.37 6.16 0.32 2.18e-9 Liver disease severity in Alagille syndrome; CRC cis rs10504229 0.775 rs72650869 chr8:58157923 T/A cg24829409 chr8:58192753 C8orf71 -0.6 -8.07 -0.41 1.29e-14 Developmental language disorder (linguistic errors); CRC cis rs6543140 0.964 rs13383602 chr2:103085962 C/T cg04239558 chr2:103089729 SLC9A4 0.37 6.61 0.34 1.51e-10 Blood protein levels; CRC cis rs4808199 1.000 rs4808199 chr19:19545099 C/T cg03709012 chr19:19516395 GATAD2A 1.04 12.44 0.57 2.14e-29 Nonalcoholic fatty liver disease; CRC cis rs9916302 0.904 rs8065963 chr17:37681332 C/T cg15445000 chr17:37608096 MED1 0.43 9.61 0.47 1.95e-19 Glomerular filtration rate (creatinine); CRC trans rs3733585 0.673 rs4697914 chr4:9952266 G/A cg26043149 chr18:55253948 FECH -0.5 -7.71 -0.39 1.51e-13 Cleft plate (environmental tobacco smoke interaction); CRC cis rs28386778 0.863 rs2584637 chr17:61942952 T/C cg11494091 chr17:61959527 GH2 0.62 10.48 0.5 2.36e-22 Prudent dietary pattern; CRC cis rs10870270 1.000 rs9971066 chr10:133788233 G/A cg08754478 chr10:133766260 PPP2R2D -0.65 -9.08 -0.45 1.05e-17 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; CRC cis rs910316 0.967 rs175502 chr14:75533679 A/G cg08847533 chr14:75593920 NEK9 -0.9 -16.81 -0.68 3.24e-46 Height; CRC cis rs3091242 0.933 rs35530120 chr1:25785451 A/G cg23205692 chr1:25664452 TMEM50A -0.4 -5.65 -0.3 3.53e-8 Erythrocyte sedimentation rate; CRC cis rs9372498 0.536 rs9481821 chr6:118846022 A/C cg07617317 chr6:118971624 C6orf204 0.47 5.9 0.31 8.84e-9 Diastolic blood pressure; CRC cis rs10504229 0.953 rs116564484 chr8:58172818 T/C cg02290350 chr8:58132656 NA -0.44 -6.39 -0.33 5.52e-10 Developmental language disorder (linguistic errors); CRC cis rs7208859 0.623 rs7220289 chr17:29103762 G/T cg01831904 chr17:28903510 LRRC37B2 -0.62 -6.34 -0.33 7.69e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs2882667 0.858 rs2043271 chr5:138459108 A/G cg09476006 chr5:138032270 NA 0.45 6.85 0.35 3.59e-11 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs651907 0.557 rs2288272 chr3:101378476 C/T cg11279151 chr3:101281821 RG9MTD1 -0.57 -7.73 -0.39 1.32e-13 Colorectal cancer; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg12698784 chr3:119813316 GSK3B 0.4 6.12 0.32 2.7e-9 Intelligence (multi-trait analysis); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg12404182 chr2:132250324 FAM128A;LOC150776 0.44 6.31 0.33 9.1e-10 Intelligence (multi-trait analysis); CRC cis rs737008 0.960 rs34764020 chr16:11378359 C/T cg00044050 chr16:11439710 C16orf75 -0.45 -6.02 -0.32 4.56e-9 Obesity-related traits; CRC trans rs1814175 0.615 rs11040654 chr11:49939485 T/G cg11707556 chr5:10655725 ANKRD33B -0.52 -9.95 -0.48 1.49e-20 Height; CRC cis rs4731207 0.596 rs13231916 chr7:124640225 A/G cg23710748 chr7:124431027 NA -0.39 -6.25 -0.33 1.24e-9 Cutaneous malignant melanoma; CRC cis rs17711722 0.701 rs55773927 chr7:65337902 T/C cg18876405 chr7:65276391 NA 0.65 11.91 0.55 1.97e-27 Calcium levels; CRC cis rs875971 0.862 rs6945775 chr7:65968974 G/A cg00343986 chr7:65444356 GUSB 0.43 6.05 0.32 3.87e-9 Aortic root size; CRC cis rs5769765 0.955 rs6520066 chr22:50294988 C/T cg08270630 chr22:50330655 NA -0.43 -6.63 -0.34 1.4e-10 Schizophrenia; CRC cis rs7666738 0.830 rs13149404 chr4:99070236 A/G cg17366294 chr4:99064904 C4orf37 0.43 7.29 0.37 2.29e-12 Colonoscopy-negative controls vs population controls; CRC cis rs13217239 0.646 rs4583981 chr6:26992023 G/T cg05192639 chr6:26864778 GUSBL1 0.31 6.01 0.31 5.05e-9 Schizophrenia; CRC trans rs10983614 1.000 rs7867776 chr9:120072627 A/G cg02726883 chr17:29421732 NF1 0.44 6.01 0.31 4.85e-9 Survival in pancreatic cancer; CRC cis rs4481887 0.927 rs7519334 chr1:248472076 C/T cg13385794 chr1:248469461 NA 0.38 6.77 0.35 5.95e-11 Common traits (Other); CRC cis rs7618915 0.531 rs77146033 chr3:52701501 G/T cg07507251 chr3:52567010 NT5DC2 0.41 5.89 0.31 9.77e-9 Bipolar disorder; CRC cis rs1552244 0.882 rs55840655 chr3:10042690 C/T cg16606324 chr3:10149918 C3orf24 0.62 8.08 0.41 1.25e-14 Alzheimer's disease; CRC cis rs10504229 0.683 rs16921817 chr8:58107563 A/T cg24829409 chr8:58192753 C8orf71 -0.56 -8.01 -0.4 2.05e-14 Developmental language disorder (linguistic errors); CRC cis rs7119 0.717 rs16968835 chr15:77734261 G/A cg17802220 chr15:77601643 NA -0.41 -6.04 -0.32 4.07e-9 Type 2 diabetes; CRC cis rs921968 0.643 rs586374 chr2:219383003 A/C cg02176678 chr2:219576539 TTLL4 0.48 8.0 0.4 2.1e-14 Mean corpuscular hemoglobin concentration; CRC cis rs2228479 0.850 rs62054610 chr16:89816920 G/A cg06558623 chr16:89946397 TCF25 1.15 10.8 0.51 1.85e-23 Skin colour saturation; CRC cis rs1348850 0.872 rs4893824 chr2:178298104 G/A cg27490568 chr2:178487706 NA 0.41 5.91 0.31 8.49e-9 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs9393777 0.546 rs9366673 chr6:26893329 C/G cg12292205 chr6:26970375 C6orf41 -0.69 -7.88 -0.4 4.87e-14 Intelligence (multi-trait analysis); CRC cis rs2477686 0.526 rs2477690 chr1:2395563 G/A cg11214544 chr1:2391121 NA -0.59 -9.31 -0.46 1.86e-18 Non-obstructive azoospermia; CRC cis rs1153858 1.000 rs4395020 chr15:45652889 A/C cg14582100 chr15:45693742 SPATA5L1 0.3 6.27 0.33 1.13e-9 Homoarginine levels; CRC cis rs10504229 0.683 rs11774585 chr8:58132685 G/A cg21724239 chr8:58056113 NA 0.49 6.81 0.35 4.75e-11 Developmental language disorder (linguistic errors); CRC cis rs17001868 0.568 rs9607701 chr22:40739116 A/G cg07138101 chr22:40742427 ADSL 0.59 7.84 0.4 6.24e-14 Mammographic density (dense area); CRC cis rs3617 0.625 rs2239548 chr3:52854186 A/C cg18099408 chr3:52552593 STAB1 -0.35 -6.0 -0.31 5.34e-9 Red blood cell count;Autism spectrum disorder or schizophrenia; CRC cis rs853679 0.517 rs1853097 chr6:28058635 A/G cg21251018 chr6:28226885 NKAPL 0.48 6.22 0.32 1.55e-9 Depression; CRC cis rs929354 0.772 rs10228145 chr7:157007337 A/G cg05182265 chr7:156933206 UBE3C -0.75 -14.28 -0.62 2.46e-36 Body mass index; CRC cis rs995000 0.899 rs1183260 chr1:62945418 A/G cg19896129 chr1:63156450 NA -0.45 -6.89 -0.36 2.83e-11 Triglyceride levels; CRC cis rs875971 0.862 rs10224872 chr7:65759773 T/A cg00343986 chr7:65444356 GUSB -0.4 -5.69 -0.3 2.77e-8 Aortic root size; CRC cis rs13108904 0.967 rs900028 chr4:1279162 A/T cg00684032 chr4:1343700 KIAA1530 0.47 6.9 0.36 2.68e-11 Obesity-related traits; CRC cis rs4666002 0.789 rs13030973 chr2:27928797 T/C cg27432699 chr2:27873401 GPN1 0.56 7.04 0.36 1.14e-11 Phospholipid levels (plasma); CRC cis rs875971 1.000 rs778726 chr7:65828731 C/T cg00343986 chr7:65444356 GUSB 0.43 6.33 0.33 8.2e-10 Aortic root size; CRC cis rs3857067 1.000 rs28840089 chr4:95000403 A/T cg11021082 chr4:95130006 SMARCAD1 -0.4 -6.04 -0.32 4.06e-9 QT interval; CRC cis rs807669 0.548 rs5748028 chr22:19172281 G/A cg02655711 chr22:19163373 SLC25A1 0.82 15.38 0.65 1.38e-40 Metabolite levels; CRC cis rs244731 0.959 rs6556307 chr5:176641434 C/T cg16006841 chr5:176797999 RGS14 0.61 8.14 0.41 8.28e-15 Urate levels in lean individuals; CRC cis rs6942756 1.000 rs2012919 chr7:128890812 C/T cg02491457 chr7:128862824 NA -0.76 -10.31 -0.49 8.66e-22 White matter hyperintensity burden; CRC cis rs4930561 1.000 rs10896298 chr11:67931459 C/T cg04465784 chr11:67976953 SUV420H1 -0.27 -5.62 -0.3 4.04e-8 Breast cancer in childhood cancer survivors;IgG glycosylation; CRC cis rs704795 0.836 rs1083865 chr2:27620827 A/G cg21248554 chr2:27665150 KRTCAP3 -0.32 -7.35 -0.38 1.59e-12 Menopause (age at onset); CRC cis rs67311347 0.544 rs4974040 chr3:40331059 G/A cg09455208 chr3:40491958 NA 0.31 6.36 0.33 6.69e-10 Renal cell carcinoma; CRC cis rs9911578 0.900 rs4793593 chr17:56892699 C/G cg05425664 chr17:57184151 TRIM37 0.47 7.26 0.37 2.9e-12 Intelligence (multi-trait analysis); CRC cis rs1552244 0.766 rs34232505 chr3:10186216 T/A cg02579736 chr3:10068473 FANCD2;CIDECP 0.94 11.95 0.55 1.45e-27 Alzheimer's disease; CRC cis rs17767392 0.834 rs61989252 chr14:71727914 G/A cg13720639 chr14:72061746 SIPA1L1 -0.52 -6.23 -0.32 1.41e-9 Mitral valve prolapse; CRC cis rs2762353 0.538 rs35670731 chr6:25728235 C/T cg07061783 chr6:25882402 NA 0.48 6.21 0.32 1.61e-9 Blood metabolite levels; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg10451772 chr3:127347880 PODXL2 0.43 7.45 0.38 8.15e-13 Liver disease severity in Alagille syndrome; CRC cis rs853679 0.517 rs3757187 chr6:28107654 T/C cg23161317 chr6:28129485 ZNF389 0.53 6.54 0.34 2.37e-10 Depression; CRC cis rs2346177 0.554 rs13002880 chr2:46708129 C/G cg26688816 chr2:46740690 ATP6V1E2 -0.62 -9.43 -0.46 7.61e-19 HDL cholesterol; CRC cis rs7705042 0.828 rs10875596 chr5:141495715 T/C cg07392085 chr5:141489673 NDFIP1 0.47 7.41 0.38 1.06e-12 Asthma; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg02500152 chr12:48357316 TMEM106C 0.44 7.09 0.36 8.31e-12 Liver disease severity in Alagille syndrome; CRC trans rs7726839 0.540 rs4957081 chr5:646418 G/C cg11887960 chr12:57824829 NA 0.64 7.2 0.37 4.1e-12 Obesity-related traits; CRC cis rs7811142 1.000 rs6962151 chr7:100028484 T/C cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.06 15.37 0.65 1.54e-40 Platelet count; CRC cis rs7086627 0.515 rs6585994 chr10:82191643 A/G cg00277334 chr10:82204260 NA -0.59 -9.99 -0.48 1.04e-20 Post bronchodilator FEV1; CRC cis rs28386778 1.000 rs2665849 chr17:61953670 T/C cg22520471 chr17:61851767 DDX42;CCDC47 0.74 11.42 0.53 1.11e-25 Prudent dietary pattern; CRC cis rs2243480 0.708 rs13242216 chr7:65898277 T/C cg12463550 chr7:65579703 CRCP 0.65 5.75 0.3 2.03e-8 Diabetic kidney disease; CRC cis rs6951245 0.572 rs80133931 chr7:1027286 C/T cg24642844 chr7:1081250 C7orf50 -0.92 -7.65 -0.39 2.18e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs35306767 0.623 rs56201968 chr10:1141666 A/G cg20503657 chr10:835505 NA 0.54 7.46 0.38 8.01e-13 Eosinophil percentage of granulocytes; CRC cis rs8077889 1.000 rs8077889 chr17:41878166 G/T cg26893861 chr17:41843967 DUSP3 -0.84 -10.99 -0.52 3.95e-24 Triglycerides; CRC cis rs13118159 0.509 rs7688922 chr4:1361011 T/C cg02018176 chr4:1364513 KIAA1530 0.72 12.38 0.56 3.77e-29 Longevity; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg23426587 chr9:21335126 KLHL9 0.47 6.69 0.35 9.75e-11 Response to antipsychotic treatment; CRC cis rs7618915 0.570 rs2336145 chr3:52629750 A/C cg10802521 chr3:52805072 NEK4 -0.58 -8.94 -0.44 2.87e-17 Bipolar disorder; CRC cis rs4713118 0.955 rs9368528 chr6:27683798 G/A cg19041857 chr6:27730383 NA -0.42 -5.94 -0.31 7.29e-9 Parkinson's disease; CRC cis rs10504229 0.639 rs56825757 chr8:58106469 A/G cg05313129 chr8:58192883 C8orf71 -0.43 -5.87 -0.31 1.09e-8 Developmental language disorder (linguistic errors); CRC trans rs10982213 0.830 rs2274163 chr9:117188714 C/T cg14363841 chr7:73185036 CLDN3 0.39 6.51 0.34 2.85e-10 Interleukin-6 levels; CRC cis rs17376456 0.825 rs10079708 chr5:93261796 G/C cg21475434 chr5:93447410 FAM172A 0.83 8.23 0.41 4.37e-15 Diabetic retinopathy; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg06589161 chr5:180618230 NA 0.4 6.47 0.34 3.45e-10 Liver disease severity in Alagille syndrome; CRC cis rs6831352 0.918 rs17218239 chr4:100057020 G/A cg13256891 chr4:100009986 ADH5 -0.66 -8.89 -0.44 4.04e-17 Alcohol dependence; CRC trans rs2303319 0.504 rs12467625 chr2:162603387 C/A cg10498984 chr16:28874827 SH2B1 -0.73 -6.3 -0.33 9.75e-10 Cognitive function; CRC cis rs796364 0.587 rs7588746 chr2:200986345 A/G cg23649088 chr2:200775458 C2orf69 0.48 5.71 0.3 2.58e-8 Schizophrenia; CRC cis rs2832191 0.791 rs2832202 chr21:30501342 G/A cg08807101 chr21:30365312 RNF160 -0.63 -9.91 -0.48 1.96e-20 Dental caries; CRC cis rs9921222 0.521 rs757460 chr16:367174 G/C cg00101154 chr16:420108 MRPL28 -0.53 -6.85 -0.35 3.73e-11 Bone mineral density (spine);Bone mineral density; CRC cis rs561341 0.883 rs72821942 chr17:30234460 C/T cg23018236 chr17:30244563 NA -0.62 -7.83 -0.4 6.75e-14 Hip circumference adjusted for BMI; CRC cis rs6679356 0.724 rs3828068 chr1:67817872 G/A cg24364144 chr1:67875067 SERBP1 0.43 6.66 0.34 1.14e-10 Primary biliary cholangitis; CRC trans rs10982213 0.830 rs2274163 chr9:117188714 C/T cg03729431 chr17:15848264 ADORA2B 0.41 6.52 0.34 2.66e-10 Interleukin-6 levels; CRC cis rs7264396 0.790 rs6060519 chr20:34217383 G/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.62 -10.09 -0.49 5.04e-21 Total cholesterol levels; CRC cis rs2228479 0.867 rs2270459 chr16:89979851 A/C cg04013166 chr16:89971882 TCF25 -0.5 -5.62 -0.3 4.13e-8 Skin colour saturation; CRC cis rs734999 0.588 rs2764842 chr1:2529192 A/G cg20673091 chr1:2541236 MMEL1 -0.36 -5.78 -0.3 1.76e-8 Ulcerative colitis; CRC cis rs11122272 0.735 rs971534 chr1:231521971 C/A cg06096015 chr1:231504339 EGLN1 0.4 5.98 0.31 5.78e-9 Hemoglobin concentration; CRC cis rs1881797 0.527 rs78486847 chr1:247638515 C/T cg05639522 chr1:247681581 NA 0.56 6.05 0.32 3.95e-9 Acute lymphoblastic leukemia (childhood); CRC cis rs7666738 0.830 rs1405767 chr4:98965295 T/C cg17366294 chr4:99064904 C4orf37 0.43 7.36 0.38 1.49e-12 Colonoscopy-negative controls vs population controls; CRC cis rs6951245 1.000 rs1997243 chr7:1083777 A/G cg26224354 chr7:1096374 C7orf50;GPR146 -0.89 -11.19 -0.53 7.61e-25 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs7937682 0.575 rs1346180 chr11:111715570 G/C cg19812747 chr11:111475976 SIK2 0.45 6.78 0.35 5.66e-11 Primary sclerosing cholangitis; CRC cis rs6456156 0.586 rs7746628 chr6:167483235 A/G cg07741184 chr6:167504864 NA 0.38 6.65 0.34 1.21e-10 Primary biliary cholangitis; CRC cis rs7089973 0.624 rs11196940 chr10:116593791 T/G cg23260525 chr10:116636907 FAM160B1 0.35 8.06 0.41 1.42e-14 Bipolar disorder or attention deficit hyperactivity disorder; CRC cis rs524281 0.773 rs2155201 chr11:65992344 T/C cg16950941 chr11:66035639 RAB1B -0.7 -8.05 -0.41 1.53e-14 Electroencephalogram traits; CRC cis rs1799949 1.000 rs11079056 chr17:41300799 C/A cg19454999 chr17:41278357 BRCA1;NBR2 0.55 8.65 0.43 2.28e-16 Menopause (age at onset); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg02429656 chr12:26275311 BHLHE41 0.41 6.16 0.32 2.12e-9 Intelligence (multi-trait analysis); CRC cis rs8060686 0.641 rs113162813 chr16:68038969 A/G cg26727032 chr16:67993705 SLC12A4 -0.54 -6.02 -0.31 4.69e-9 HDL cholesterol;Metabolic syndrome; CRC cis rs1843834 0.539 rs3912999 chr2:225390089 C/T cg22455342 chr2:225449267 CUL3 0.64 8.9 0.44 3.79e-17 IgE levels in asthmatics (D.p. specific); CRC cis rs12142240 0.698 rs41293285 chr1:46808426 C/T cg14993813 chr1:46806288 NSUN4 -0.49 -6.22 -0.32 1.5e-9 Menopause (age at onset); CRC cis rs9329221 0.620 rs6601427 chr8:10156025 A/G cg27411982 chr8:10470053 RP1L1 -0.36 -5.86 -0.31 1.13e-8 Neuroticism; CRC trans rs2303319 0.582 rs12464282 chr2:162448855 C/T cg22988483 chr14:93581567 ITPK1 -0.66 -6.07 -0.32 3.43e-9 Cognitive function; CRC cis rs10751667 0.666 rs7944815 chr11:959776 C/T cg06064525 chr11:970664 AP2A2 -0.3 -6.21 -0.32 1.58e-9 Alzheimer's disease (late onset); CRC cis rs1552244 1.000 rs12374115 chr3:10134766 A/G cg00166722 chr3:10149974 C3orf24 -0.63 -8.43 -0.42 1.13e-15 Alzheimer's disease; CRC cis rs780096 0.506 rs1647265 chr2:27692261 A/G cg12000995 chr2:27665139 KRTCAP3 -0.32 -6.67 -0.35 1.1e-10 Total body bone mineral density; CRC cis rs7927771 0.832 rs7940536 chr11:47395240 G/A cg05585544 chr11:47624801 NA 0.48 8.6 0.43 3.29e-16 Subjective well-being; CRC cis rs11997175 0.583 rs4739562 chr8:33844064 C/T cg04338863 chr8:33670619 NA -0.43 -6.04 -0.32 4.17e-9 Body mass index; CRC cis rs7258465 1.000 rs4808134 chr19:18608579 G/A cg10790698 chr19:18539756 SSBP4 -0.44 -8.44 -0.42 1e-15 Breast cancer; CRC cis rs1005277 0.579 rs116912400 chr10:38479207 G/T cg00409905 chr10:38381863 ZNF37A -0.65 -10.65 -0.51 5.95e-23 Extrinsic epigenetic age acceleration; CRC cis rs951366 0.585 rs72750964 chr1:205675240 C/T cg17178900 chr1:205818956 PM20D1 0.66 9.26 0.45 2.82e-18 Menarche (age at onset); CRC trans rs9329221 0.683 rs525726 chr8:9887797 G/C cg16141378 chr3:129829833 LOC729375 0.43 6.48 0.34 3.26e-10 Neuroticism; CRC cis rs919433 0.713 rs10178946 chr2:198463090 G/T cg10820045 chr2:198174542 NA 0.42 7.15 0.37 5.7e-12 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC cis rs7617773 0.501 rs12185901 chr3:48382919 G/T cg11946769 chr3:48343235 NME6 0.6 8.14 0.41 8.14e-15 Coronary artery disease; CRC cis rs11105298 0.891 rs10858898 chr12:89922111 A/G cg00757033 chr12:89920650 WDR51B 0.36 5.91 0.31 8.52e-9 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; CRC cis rs2832191 0.647 rs11170 chr21:30378090 C/T cg08807101 chr21:30365312 RNF160 0.7 11.11 0.52 1.5e-24 Dental caries; CRC cis rs79387448 0.701 rs11465586 chr2:102982709 C/G cg09003973 chr2:102972529 NA 0.99 10.97 0.52 4.69e-24 Gut microbiota (bacterial taxa); CRC cis rs11098699 0.821 rs1562063 chr4:124204110 G/A cg09941581 chr4:124220074 SPATA5 0.4 5.87 0.31 1.08e-8 Mosquito bite size; CRC cis rs875971 0.895 rs778700 chr7:65866450 C/T cg00343986 chr7:65444356 GUSB 0.43 6.3 0.33 9.66e-10 Aortic root size; CRC trans rs1933755 0.541 rs9375743 chr6:130907220 A/G cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.91 -6.52 -0.34 2.64e-10 Colorectal cancer (calcium intake interaction); CRC cis rs1005224 0.864 rs11625011 chr14:76144828 G/A cg04684003 chr14:76127793 TTLL5;C14orf1 -0.45 -6.42 -0.33 4.65e-10 Large artery stroke; CRC cis rs4862750 0.872 rs6836781 chr4:187899701 G/A cg22105103 chr4:187893119 NA 0.64 11.71 0.54 1.01e-26 Lobe attachment (rater-scored or self-reported); CRC cis rs3764400 0.564 rs12602670 chr17:46104880 T/C cg10706073 chr17:46328419 SKAP1 -0.65 -6.85 -0.35 3.56e-11 Body mass index; CRC trans rs10504229 1.000 rs60231757 chr8:58169937 T/C cg04077850 chr5:125800366 GRAMD3 0.37 6.27 0.33 1.15e-9 Developmental language disorder (linguistic errors); CRC cis rs780096 0.526 rs7594812 chr2:27611469 A/G cg17158414 chr2:27665306 KRTCAP3 -0.28 -6.01 -0.31 5.01e-9 Total body bone mineral density; CRC cis rs6586163 0.872 rs7910660 chr10:90743197 G/A cg13456138 chr10:90753195 FAS -0.44 -6.58 -0.34 1.84e-10 Chronic lymphocytic leukemia; CRC cis rs10504229 0.683 rs79284841 chr8:58107611 T/A cg21724239 chr8:58056113 NA 0.81 9.75 0.47 6.8e-20 Developmental language disorder (linguistic errors); CRC trans rs10983614 1.000 rs7867776 chr9:120072627 A/G cg20651681 chr7:50861418 GRB10 0.45 6.04 0.32 4.2e-9 Survival in pancreatic cancer; CRC cis rs7772486 0.875 rs9373485 chr6:146401429 A/T cg23711669 chr6:146136114 FBXO30 0.65 11.34 0.53 2.23e-25 Lobe attachment (rater-scored or self-reported); CRC cis rs2952156 0.883 rs1495100 chr17:37832279 C/T cg07936489 chr17:37558343 FBXL20 -0.41 -5.88 -0.31 1.01e-8 Asthma; CRC cis rs6502050 0.835 rs8067875 chr17:80092778 C/T cg13198984 chr17:80129470 CCDC57 0.48 8.52 0.43 5.9e-16 Life satisfaction; CRC cis rs9296736 0.890 rs9370258 chr6:53910988 T/G cg04374786 chr6:53939321 C6orf142 0.44 6.89 0.35 2.93e-11 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs666930 1.000 rs666930 chr1:120258970 A/G cg19096424 chr1:120255104 PHGDH 0.39 5.73 0.3 2.26e-8 Breast cancer; CRC cis rs4727027 0.769 rs10952797 chr7:148816722 A/T cg23583168 chr7:148888333 NA -0.92 -15.94 -0.66 8.83e-43 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC cis rs4423214 0.879 rs1790324 chr11:71150520 A/C cg13043300 chr11:71146211 DHCR7 -0.41 -5.85 -0.31 1.16e-8 Vitamin D levels; CRC cis rs11628318 0.614 rs10782496 chr14:103079725 C/G cg12046867 chr14:103022105 NA -0.44 -6.42 -0.33 4.76e-10 Platelet count; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg08483723 chr3:45267960 TMEM158 0.34 6.84 0.35 3.86e-11 Liver disease severity in Alagille syndrome; CRC cis rs2985684 0.895 rs3007033 chr14:50103816 T/C cg04989706 chr14:50066350 PPIL5 -0.5 -6.88 -0.35 3.09e-11 Carotid intima media thickness; CRC cis rs72781680 0.699 rs72794291 chr2:23897935 C/T cg08917208 chr2:24149416 ATAD2B 1.02 9.16 0.45 5.8e-18 Lymphocyte counts; CRC cis rs11148252 0.624 rs6561682 chr13:53266297 A/G cg02158880 chr13:53174818 NA -0.49 -6.95 -0.36 1.96e-11 Lewy body disease; CRC cis rs8072100 0.676 rs9905308 chr17:45409386 T/A cg25173405 chr17:45401733 C17orf57 -0.6 -10.33 -0.49 7.36e-22 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs473651 0.935 rs541128 chr2:239336449 A/G cg18131467 chr2:239335373 ASB1 1.03 23.54 0.79 1.63e-72 Multiple system atrophy; CRC cis rs10504229 1.000 rs1390411 chr8:58194146 C/A cg02290350 chr8:58132656 NA -0.42 -6.14 -0.32 2.33e-9 Developmental language disorder (linguistic errors); CRC cis rs2842992 0.915 rs2758350 chr6:160118056 A/G cg19482086 chr6:160211437 TCP1;MRPL18 0.69 8.63 0.43 2.64e-16 Age-related macular degeneration (geographic atrophy); CRC cis rs7131987 0.934 rs7316004 chr12:29411698 C/T cg09582351 chr12:29534625 ERGIC2 -0.28 -6.02 -0.31 4.66e-9 QT interval; CRC trans rs17685 0.712 rs11770149 chr7:75791644 G/A cg19862616 chr7:65841803 NCRNA00174 0.93 16.02 0.66 4.19e-43 Coffee consumption;Coffee consumption (cups per day); CRC cis rs67311347 1.000 rs9833430 chr3:40459043 C/T cg24209194 chr3:40518798 ZNF619 0.41 5.89 0.31 9.61e-9 Renal cell carcinoma; CRC cis rs56011263 0.687 rs4690293 chr4:706101 A/G cg14024328 chr4:719362 PCGF3 -0.56 -7.96 -0.4 2.85e-14 White blood cell count; CRC cis rs3091242 0.933 rs35403885 chr1:25784551 G/A cg27572855 chr1:25598939 RHD -0.36 -6.18 -0.32 1.94e-9 Erythrocyte sedimentation rate; CRC cis rs4601821 0.895 rs1055075 chr11:113239512 T/C cg14159747 chr11:113255604 NA 0.49 9.18 0.45 4.98e-18 Alcoholic chronic pancreatitis; CRC cis rs60871478 0.636 rs55663559 chr7:884057 G/A cg05535760 chr7:792225 HEATR2 -0.91 -10.26 -0.49 1.35e-21 Cerebrospinal P-tau181p levels; CRC cis rs595982 0.527 rs73061656 chr19:49372355 G/A cg15549821 chr19:49342101 PLEKHA4 -0.59 -6.87 -0.35 3.2e-11 Red cell distribution width; CRC cis rs6696846 0.765 rs72757524 chr1:205086473 C/T cg03948781 chr1:205179583 DSTYK 0.4 5.6 0.3 4.51e-8 Red blood cell count; CRC cis rs1572438 0.965 rs3799324 chr6:859376 G/A cg13447295 chr6:887704 NA -0.44 -6.16 -0.32 2.16e-9 Aging; CRC cis rs1568889 0.838 rs7131053 chr11:28143312 A/G cg06544937 chr11:28130018 METT5D1;KIF18A 0.91 15.54 0.65 3.21e-41 Bipolar disorder; CRC cis rs9467711 0.606 rs9379875 chr6:26444732 C/T cg14345882 chr6:26364793 BTN3A2 0.7 5.67 0.3 3.1e-8 Autism spectrum disorder or schizophrenia; CRC cis rs904251 0.580 rs62408367 chr6:37444813 G/A cg01843034 chr6:37503916 NA -0.33 -5.81 -0.3 1.48e-8 Cognitive performance; CRC cis rs4713118 0.955 rs9468203 chr6:27688667 A/G cg25164649 chr6:28176230 NA 0.52 6.83 0.35 4.2e-11 Parkinson's disease; CRC cis rs11758351 0.588 rs2050948 chr6:26234952 A/G cg10723962 chr6:26240782 HIST1H4F -0.39 -6.27 -0.33 1.15e-9 Gout;Renal underexcretion gout; CRC cis rs4523957 0.890 rs9895551 chr17:2115922 C/G cg16513277 chr17:2031491 SMG6 0.54 9.04 0.45 1.33e-17 Autism spectrum disorder or schizophrenia;Schizophrenia; CRC cis rs1953600 0.645 rs2573351 chr10:81931441 A/G cg11900509 chr10:81946545 ANXA11 -0.4 -6.58 -0.34 1.9e-10 Sarcoidosis; CRC cis rs870825 0.655 rs6552812 chr4:185653568 C/T cg04058563 chr4:185651563 MLF1IP -0.76 -9.21 -0.45 3.91e-18 Blood protein levels; CRC cis rs208520 0.874 rs208469 chr6:66915891 T/C cg07460842 chr6:66804631 NA -0.91 -12.19 -0.56 1.77e-28 Exhaled nitric oxide output; CRC cis rs1018836 0.828 rs7006279 chr8:91605364 A/G cg16814680 chr8:91681699 NA -0.69 -10.56 -0.5 1.21e-22 Ejection fraction in Tripanosoma cruzi seropositivity; CRC trans rs9929218 0.954 rs12599393 chr16:68829021 C/T cg04657470 chr2:198365150 HSPE1;HSPD1 -0.77 -11.03 -0.52 2.86e-24 Colorectal cancer; CRC cis rs317689 0.718 rs315130 chr12:69761444 T/C cg20891283 chr12:69753455 YEATS4 0.67 8.52 0.43 5.83e-16 Response to diuretic therapy; CRC cis rs4665809 1.000 rs6546766 chr2:26328680 T/C cg04944784 chr2:26401820 FAM59B -0.6 -7.57 -0.39 3.84e-13 Gut microbiome composition (summer); CRC cis rs6534441 0.857 rs59780240 chr4:125457329 A/C cg21609808 chr4:125404261 NA 0.38 5.75 0.3 2.07e-8 Major depressive disorder; CRC cis rs875971 1.000 rs10257427 chr7:65743208 T/C cg18876405 chr7:65276391 NA -0.52 -8.9 -0.44 3.88e-17 Aortic root size; CRC cis rs17767392 0.914 rs35613269 chr14:71887814 G/A cg13720639 chr14:72061746 SIPA1L1 -0.55 -6.95 -0.36 1.96e-11 Mitral valve prolapse; CRC cis rs10924970 0.601 rs4659647 chr1:235379186 G/A cg09010748 chr1:235293032 TOMM20 -0.42 -5.89 -0.31 9.32e-9 Asthma; CRC cis rs7098414 0.530 rs4146515 chr10:82116602 G/A cg00277334 chr10:82204260 NA -0.46 -7.53 -0.38 5.02e-13 Post bronchodilator FEV1; CRC trans rs1814175 0.645 rs11040535 chr11:49808669 C/T cg03929089 chr4:120376271 NA -0.89 -15.11 -0.64 1.55e-39 Height; CRC cis rs910316 1.000 rs12589876 chr14:75544189 G/A cg08847533 chr14:75593920 NEK9 0.93 17.81 0.7 3.75e-50 Height; CRC cis rs7618501 0.633 rs4688755 chr3:50064424 G/A cg24110177 chr3:50126178 RBM5 0.47 7.13 0.37 6.43e-12 Intelligence (multi-trait analysis); CRC cis rs2380220 0.720 rs9400397 chr6:95980623 C/A cg15832292 chr6:96025679 MANEA 0.6 6.57 0.34 2e-10 Behavioural disinhibition (generation interaction); CRC cis rs798554 0.757 rs1182181 chr7:2873247 C/G cg14895029 chr7:2775587 GNA12 -0.4 -5.83 -0.31 1.3e-8 Height; CRC trans rs3743266 0.613 rs2414669 chr15:60708824 A/G cg04091063 chr1:19615382 AKR7A3 0.37 5.97 0.31 6.31e-9 Menarche (age at onset); CRC cis rs3820068 0.581 rs72645893 chr1:15930943 C/G cg13390004 chr1:15929781 NA 0.51 7.2 0.37 4.22e-12 Systolic blood pressure; CRC cis rs6831352 0.918 rs4699713 chr4:100060513 C/T cg12011299 chr4:100065546 ADH4 -0.5 -9.49 -0.46 5.01e-19 Alcohol dependence; CRC cis rs853679 0.517 rs35193936 chr6:28076270 A/G cg21251018 chr6:28226885 NKAPL 0.48 6.26 0.33 1.17e-9 Depression; CRC cis rs116095464 0.558 rs28635197 chr5:279071 T/C cg22496380 chr5:211416 CCDC127 -0.88 -10.05 -0.48 6.51e-21 Breast cancer; CRC cis rs116095464 0.558 rs6875291 chr5:264192 T/C cg22496380 chr5:211416 CCDC127 -0.91 -10.46 -0.5 2.65e-22 Breast cancer; CRC cis rs6028335 0.502 rs7265661 chr20:37586842 G/T cg27552599 chr20:37590471 DHX35 0.39 5.97 0.31 6.23e-9 Alcohol and nicotine co-dependence; CRC cis rs7552404 0.731 rs10873808 chr1:76406767 T/C cg22875332 chr1:76189707 ACADM 0.55 6.54 0.34 2.41e-10 Blood metabolite levels;Acylcarnitine levels; CRC cis rs1218582 0.772 rs6683557 chr1:154852307 C/G cg09359103 chr1:154839909 KCNN3 -0.74 -13.32 -0.59 1.1e-32 Prostate cancer; CRC cis rs12200560 0.505 rs211173 chr6:97070804 C/T cg06623918 chr6:96969491 KIAA0776 0.48 7.01 0.36 1.38e-11 Coronary heart disease; CRC cis rs2836974 0.897 rs13047678 chr21:40708853 C/T cg17971929 chr21:40555470 PSMG1 0.67 8.97 0.44 2.34e-17 Cognitive function; CRC cis rs1799949 1.000 rs11655505 chr17:41278377 G/A cg25072359 chr17:41440525 NA 0.46 6.93 0.36 2.19e-11 Menopause (age at onset); CRC cis rs514406 0.929 rs485631 chr1:53330245 A/G cg25767906 chr1:53392781 SCP2 -0.51 -8.33 -0.42 2.23e-15 Monocyte count; CRC cis rs977987 0.645 rs10871311 chr16:75450912 T/A cg03315344 chr16:75512273 CHST6 0.55 9.28 0.46 2.28e-18 Dupuytren's disease; CRC cis rs9372498 0.536 rs62422236 chr6:118972633 G/T cg15382696 chr6:118971807 C6orf204 0.57 6.78 0.35 5.6e-11 Diastolic blood pressure; CRC cis rs9372498 0.536 rs62422227 chr6:118957200 C/G cg22561889 chr6:118971681 C6orf204 0.52 6.58 0.34 1.91e-10 Diastolic blood pressure; CRC cis rs7584330 0.554 rs729389 chr2:238425118 G/A cg08992911 chr2:238395768 MLPH 0.47 5.76 0.3 1.9e-8 Prostate cancer; CRC cis rs9322193 0.923 rs4870509 chr6:150023348 C/G cg13206674 chr6:150067644 NUP43 0.65 9.35 0.46 1.44e-18 Lung cancer; CRC cis rs1178968 0.748 rs10271751 chr7:72752062 T/C cg25889504 chr7:72793014 NA 0.53 6.04 0.32 4.16e-9 Triglyceride levels; CRC cis rs28493229 0.708 rs78084428 chr19:41160097 G/A cg21869046 chr19:41225005 ITPKC 0.4 6.06 0.32 3.69e-9 Kawasaki disease; CRC cis rs59104589 0.583 rs73018185 chr2:242241706 C/T cg19488206 chr2:242435732 STK25 0.47 6.54 0.34 2.37e-10 Fibrinogen levels; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg06539400 chr16:4365605 NA -0.42 -6.16 -0.32 2.15e-9 Myopia (pathological); CRC cis rs589448 0.538 rs622656 chr12:69753595 C/T cg14784868 chr12:69753453 YEATS4 0.67 9.13 0.45 7.25e-18 Cerebrospinal fluid biomarker levels; CRC cis rs6121246 0.909 rs3203770 chr20:30382315 A/G cg13852791 chr20:30311386 BCL2L1 0.72 11.41 0.53 1.22e-25 Mean corpuscular hemoglobin; CRC cis rs7914558 1.000 rs10883826 chr10:104830819 A/G cg15744005 chr10:104629667 AS3MT -0.34 -7.15 -0.37 5.59e-12 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg11355319 chr5:89825117 LYSMD3 0.57 7.67 0.39 1.91e-13 Thyroid stimulating hormone; CRC cis rs990171 1.000 rs6750020 chr2:102994714 G/A cg03938978 chr2:103052716 IL18RAP 0.46 5.82 0.31 1.37e-8 Lymphocyte counts; CRC cis rs4589502 1.000 rs79390908 chr15:67130924 C/T cg12317470 chr15:67143691 NA 0.75 6.11 0.32 2.77e-9 Lung cancer (smoking interaction); CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg22045829 chr13:60970476 TDRD3 0.44 5.99 0.31 5.58e-9 Anxiety disorder; CRC cis rs16937 0.662 rs10900468 chr1:205163057 A/G cg00857998 chr1:205179979 DSTYK 0.41 5.65 0.3 3.49e-8 Schizophrenia; CRC cis rs10493773 0.630 rs3753790 chr1:86174772 T/C cg17807903 chr1:86174739 ZNHIT6 -0.65 -17.77 -0.7 5.54e-50 Urate levels in overweight individuals; CRC cis rs951366 0.617 rs823075 chr1:205774897 C/T cg07167872 chr1:205819463 PM20D1 0.99 17.82 0.7 3.29e-50 Menarche (age at onset); CRC cis rs9549260 0.564 rs4941989 chr13:41299687 T/C cg21288729 chr13:41239152 FOXO1 0.42 6.58 0.34 1.82e-10 Red blood cell count; CRC trans rs2303319 0.504 rs62187655 chr2:162487440 C/G cg25193742 chr10:104614220 C10orf32 -0.73 -5.97 -0.31 6.18e-9 Cognitive function; CRC cis rs12230513 0.732 rs4356858 chr12:55867290 A/T cg19537932 chr12:55886519 OR6C68 -0.71 -8.93 -0.44 3.12e-17 Contrast sensitivity; CRC cis rs17685 0.593 rs56265719 chr7:75796269 C/T cg16489192 chr7:75678113 MDH2;STYXL1 -0.38 -5.89 -0.31 9.69e-9 Coffee consumption;Coffee consumption (cups per day); CRC cis rs2243480 1.000 rs458291 chr7:65520479 C/A cg12463550 chr7:65579703 CRCP 0.75 6.72 0.35 7.94e-11 Diabetic kidney disease; CRC cis rs2836974 0.563 rs6517522 chr21:40553845 T/C cg06238570 chr21:40685208 BRWD1 0.48 6.67 0.35 1.07e-10 Cognitive function; CRC cis rs2806561 0.514 rs11801120 chr1:23543307 C/T cg24466277 chr1:23519622 HTR1D -0.44 -5.95 -0.31 6.77e-9 Height; CRC cis rs10046574 0.561 rs10215176 chr7:135198589 A/G cg27474649 chr7:135195673 CNOT4 0.67 6.16 0.32 2.14e-9 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs7617773 0.743 rs13081633 chr3:48357281 A/G cg11946769 chr3:48343235 NME6 0.75 10.0 0.48 1e-20 Coronary artery disease; CRC cis rs1552244 1.000 rs9809061 chr3:10085130 C/G cg02579736 chr3:10068473 FANCD2;CIDECP 0.97 13.13 0.59 6.13e-32 Alzheimer's disease; CRC trans rs1814175 0.566 rs1811673 chr11:49602134 A/G cg11707556 chr5:10655725 ANKRD33B -0.5 -8.13 -0.41 8.89e-15 Height; CRC cis rs4988958 0.565 rs1035125 chr2:103033839 C/A cg03938978 chr2:103052716 IL18RAP 0.59 10.13 0.49 3.5e-21 Asthma (childhood onset); CRC cis rs116095464 0.558 rs7356561 chr5:284381 G/C cg22857025 chr5:266934 NA -1.24 -16.52 -0.67 4.4e-45 Breast cancer; CRC cis rs4409675 0.576 rs7520860 chr1:28232952 C/A cg23691781 chr1:28212827 C1orf38 0.34 7.88 0.4 4.9e-14 Corneal astigmatism; CRC cis rs7666738 0.830 rs7678911 chr4:99057430 C/T cg17366294 chr4:99064904 C4orf37 0.45 7.68 0.39 1.83e-13 Colonoscopy-negative controls vs population controls; CRC cis rs4713118 0.513 rs149944 chr6:28002818 C/T cg12273811 chr6:28175739 NA 0.55 8.1 0.41 1.06e-14 Parkinson's disease; CRC cis rs2415984 0.622 rs12434073 chr14:46921265 G/A cg14871534 chr14:47121158 RPL10L -0.41 -5.98 -0.31 5.86e-9 Number of children ever born; CRC cis rs798554 0.655 rs798492 chr7:2799184 C/T cg13628971 chr7:2884303 GNA12 -0.43 -6.53 -0.34 2.52e-10 Height; CRC cis rs1218582 0.740 rs1977879 chr1:154879743 G/A cg03351412 chr1:154909251 PMVK 0.54 8.68 0.43 1.92e-16 Prostate cancer; CRC trans rs8123881 0.733 rs7268466 chr20:15810676 C/T cg03844380 chr14:100680408 NA 0.57 6.06 0.32 3.76e-9 Body mass index; CRC cis rs28386778 0.863 rs1376110 chr17:61779927 A/C cg23090583 chr17:61904693 PSMC5;FTSJ3 1.03 18.47 0.71 9.51e-53 Prudent dietary pattern; CRC cis rs7632954 0.567 rs9864415 chr3:8512668 A/G cg03495237 chr3:8533978 NA -0.33 -6.07 -0.32 3.43e-9 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs11123610 0.520 rs35752035 chr2:3721353 G/C cg02938936 chr2:3718203 ALLC 0.43 5.65 0.3 3.54e-8 Response to inhaled corticosteroid treatment in asthma (change in FEV1); CRC cis rs2032447 0.802 rs12346 chr6:26097046 T/C cg27635394 chr6:26043820 HIST1H2BB 0.41 5.86 0.31 1.15e-8 Intelligence (multi-trait analysis); CRC cis rs55788414 0.932 rs35326835 chr16:81190413 T/C cg06400318 chr16:81190750 PKD1L2 -0.68 -6.92 -0.36 2.33e-11 Left ventricular obstructive tract defect (maternal effect); CRC cis rs9325144 0.560 rs6582539 chr12:38630097 C/T cg13010199 chr12:38710504 ALG10B -0.43 -6.12 -0.32 2.68e-9 Morning vs. evening chronotype; CRC cis rs7107174 0.892 rs4945265 chr11:78027458 G/A cg02023728 chr11:77925099 USP35 0.53 7.54 0.38 4.65e-13 Testicular germ cell tumor; CRC cis rs7618915 0.501 rs2109634 chr3:52752075 T/G cg18404041 chr3:52824283 ITIH1 -0.4 -8.28 -0.42 3.21e-15 Bipolar disorder; CRC cis rs4604732 0.631 rs11490201 chr1:247626262 A/G cg12758973 chr1:247694275 LOC148824;OR2C3 0.42 6.18 0.32 1.9e-9 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CRC cis rs4718428 0.705 rs12536410 chr7:66254290 G/A cg12165864 chr7:66369176 NA -0.41 -5.68 -0.3 2.9e-8 Corneal structure; CRC cis rs763014 0.932 rs2384975 chr16:651115 G/T cg02475695 chr16:616220 NHLRC4 0.48 8.0 0.4 2.13e-14 Height; CRC trans rs2303319 0.504 rs58622044 chr2:162596287 A/G cg10498984 chr16:28874827 SH2B1 -0.73 -6.25 -0.33 1.3e-9 Cognitive function; CRC cis rs2732480 0.557 rs2409004 chr12:48721451 T/C cg04545296 chr12:48745243 ZNF641 0.33 5.66 0.3 3.24e-8 Hemoglobin concentration;Red blood cell count;Hematocrit; CRC cis rs1552244 0.882 rs3846168 chr3:9996925 C/T cg08888203 chr3:10149979 C3orf24 0.62 8.58 0.43 3.76e-16 Alzheimer's disease; CRC cis rs9486715 1.000 rs6899647 chr6:97065661 A/G cg06623918 chr6:96969491 KIAA0776 -0.9 -15.14 -0.64 1.18e-39 Headache; CRC cis rs3741151 0.686 rs12290701 chr11:73271988 T/C cg17517138 chr11:73019481 ARHGEF17 0.55 5.62 0.3 4.03e-8 GIP levels in response to oral glucose tolerance test (120 minutes); CRC cis rs11809207 0.523 rs2783626 chr1:26501044 C/T cg24519413 chr1:26490540 NA -0.37 -6.3 -0.33 9.37e-10 Height; CRC cis rs12580194 0.593 rs3935215 chr12:55792401 T/A cg23425280 chr12:56401806 NA 0.46 5.62 0.3 4.07e-8 Cancer; CRC cis rs6921919 0.789 rs13210258 chr6:28308671 G/T cg15845792 chr6:28175446 NA 0.46 5.85 0.31 1.2e-8 Autism spectrum disorder or schizophrenia; CRC cis rs1707322 0.686 rs2275085 chr1:46085852 C/T cg03146154 chr1:46216737 IPP -0.66 -9.54 -0.47 3.32e-19 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs7487075 0.930 rs4076484 chr12:46833912 C/G cg17501823 chr12:47219793 SLC38A4 0.32 5.94 0.31 7.11e-9 Itch intensity from mosquito bite; CRC cis rs6502050 0.835 rs3924780 chr17:80112978 G/A cg19223190 chr17:80058835 NA 0.4 6.36 0.33 6.88e-10 Life satisfaction; CRC cis rs9443645 0.901 rs9352667 chr6:79572296 A/G cg09184832 chr6:79620586 NA 0.52 10.01 0.48 9.31e-21 Intelligence (multi-trait analysis); CRC cis rs4713118 0.586 rs9468290 chr6:28087674 C/T cg25164649 chr6:28176230 NA 0.77 9.5 0.46 4.6e-19 Parkinson's disease; CRC cis rs8180040 0.932 rs62246474 chr3:47398130 C/T cg10298567 chr3:47292165 KIF9 0.43 7.08 0.36 8.79e-12 Colorectal cancer; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg08322149 chr10:46222875 FAM21C 0.42 6.1 0.32 3.01e-9 Intelligence (multi-trait analysis); CRC cis rs4665809 0.590 rs6730317 chr2:26419482 C/T cg27170947 chr2:26402098 FAM59B -0.65 -8.45 -0.42 9.52e-16 Gut microbiome composition (summer); CRC cis rs13256369 0.760 rs7839473 chr8:8575836 C/T cg06671706 chr8:8559999 CLDN23 0.54 7.98 0.4 2.44e-14 Obesity-related traits; CRC cis rs10504229 0.861 rs116923397 chr8:58185162 T/G cg02290350 chr8:58132656 NA -0.42 -5.97 -0.31 6.16e-9 Developmental language disorder (linguistic errors); CRC cis rs972578 1.000 rs5759066 chr22:43366296 G/A cg01576275 chr22:43409880 NA -0.44 -7.14 -0.37 6.09e-12 Mean platelet volume; CRC cis rs1023500 0.551 rs133371 chr22:42465574 G/A cg15557168 chr22:42548783 NA -0.38 -6.64 -0.34 1.27e-10 Schizophrenia; CRC cis rs11098499 0.865 rs2389809 chr4:120377399 T/C cg24375607 chr4:120327624 NA 0.5 7.73 0.39 1.3e-13 Corneal astigmatism; CRC cis rs501120 0.657 rs617542 chr10:44743636 G/A cg09554077 chr10:44749378 NA 0.83 10.78 0.51 2.11e-23 Coronary artery disease;Coronary heart disease; CRC cis rs8072100 0.967 rs4793842 chr17:45671506 G/A cg08085267 chr17:45401833 C17orf57 0.61 9.65 0.47 1.44e-19 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs1448094 0.511 rs17279240 chr12:86162550 A/T cg18827107 chr12:86230957 RASSF9 -0.37 -5.73 -0.3 2.23e-8 Major depressive disorder; CRC cis rs651907 0.535 rs13059470 chr3:101424800 A/G cg11279151 chr3:101281821 RG9MTD1 0.52 7.15 0.37 5.8e-12 Colorectal cancer; CRC cis rs16867321 1.000 rs10185265 chr2:181438860 G/C cg23363182 chr2:181467187 NA -0.54 -6.87 -0.35 3.29e-11 Obesity; CRC cis rs8177253 0.798 rs9871148 chr3:133507509 T/C cg01448562 chr3:133502909 NA -0.67 -11.71 -0.54 1.04e-26 Iron status biomarkers; CRC cis rs1129187 0.902 rs6907751 chr6:42944850 C/T cg02359409 chr6:42947317 PEX6 -0.59 -9.34 -0.46 1.51e-18 Alzheimer's disease in APOE e4+ carriers; CRC trans rs7618501 0.602 rs2624853 chr3:50128893 A/G cg21659725 chr3:3221576 CRBN -0.55 -8.7 -0.43 1.64e-16 Intelligence (multi-trait analysis); CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg16857181 chr7:32931955 KBTBD2 0.46 6.02 0.31 4.58e-9 Thyroid stimulating hormone; CRC cis rs7618915 0.547 rs13064064 chr3:52657002 T/C cg07507251 chr3:52567010 NT5DC2 0.43 6.15 0.32 2.19e-9 Bipolar disorder; CRC cis rs2279817 1.000 rs905389 chr1:18021406 T/C cg21791023 chr1:18019539 ARHGEF10L 0.49 6.3 0.33 9.54e-10 Neuroticism; CRC cis rs9928842 0.941 rs8057145 chr16:75256251 A/G cg09066997 chr16:75300724 BCAR1 0.68 6.65 0.34 1.19e-10 Alcoholic chronic pancreatitis; CRC cis rs7945705 0.791 rs4579928 chr11:8815704 A/G cg12365402 chr11:9010492 NRIP3 0.36 6.15 0.32 2.28e-9 Hemoglobin concentration; CRC cis rs807669 0.525 rs2073740 chr22:19196112 A/C cg02655711 chr22:19163373 SLC25A1 -0.53 -8.77 -0.44 1.01e-16 Metabolite levels; CRC cis rs875971 0.929 rs778692 chr7:65872449 A/G cg18876405 chr7:65276391 NA 0.52 9.04 0.45 1.37e-17 Aortic root size; CRC cis rs7726839 0.561 rs72703046 chr5:580129 T/C cg09021430 chr5:549028 NA -0.86 -10.87 -0.51 9.9e-24 Obesity-related traits; CRC cis rs775227 0.574 rs60131925 chr3:113034768 T/C cg18753928 chr3:113234510 CCDC52 -0.53 -6.56 -0.34 2.07e-10 Dental caries; CRC cis rs6662572 0.901 rs28484896 chr1:46184200 C/G cg03123370 chr1:45965343 CCDC163P;MMACHC 0.5 6.14 0.32 2.33e-9 Blood protein levels; CRC trans rs9354352 0.818 rs9453548 chr6:66691885 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.58 -8.63 -0.43 2.74e-16 Initial pursuit acceleration in psychotic disorders; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg08949621 chr15:42265044 EHD4 0.43 6.18 0.32 1.9e-9 Intelligence (multi-trait analysis); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg11227645 chr1:224544764 CNIH4 0.38 6.01 0.31 4.94e-9 Liver disease severity in Alagille syndrome; CRC cis rs514406 0.698 rs511599 chr1:53362818 T/C cg25767906 chr1:53392781 SCP2 -0.49 -7.56 -0.38 3.96e-13 Monocyte count; CRC cis rs7818382 1.000 rs7818382 chr8:96054000 C/T cg23172400 chr8:95962367 TP53INP1 -0.48 -7.91 -0.4 4.04e-14 Alzheimer's disease (late onset); CRC cis rs11148252 0.574 rs3742297 chr13:53278067 T/C cg00495681 chr13:53174319 NA 0.9 17.25 0.69 5.9e-48 Lewy body disease; CRC cis rs7605378 0.752 rs769960 chr2:200710706 G/T cg23649088 chr2:200775458 C2orf69 -0.66 -9.57 -0.47 2.6e-19 Osteoporosis; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg07853084 chr13:73632891 KLF5 0.4 6.14 0.32 2.32e-9 Liver disease severity in Alagille syndrome; CRC trans rs2303319 0.504 rs62189047 chr2:162613314 T/A cg20024234 chr21:43431083 ZNF295 -0.66 -5.99 -0.31 5.57e-9 Cognitive function; CRC cis rs12142240 0.698 rs3991877 chr1:46853749 C/A cg00530320 chr1:46809349 NSUN4 0.59 8.07 0.41 1.35e-14 Menopause (age at onset); CRC cis rs13064411 0.696 rs2087129 chr3:113142769 T/A cg18753928 chr3:113234510 CCDC52 -0.51 -7.29 -0.37 2.27e-12 Response to simvastatin treatment (PCSK9 protein level change); CRC cis rs2361718 0.500 rs12451697 chr17:78100690 T/A cg12100956 chr17:78086420 GAA -0.36 -5.8 -0.3 1.54e-8 Yeast infection; CRC cis rs6582630 0.634 rs10748443 chr12:38734062 G/T cg13010199 chr12:38710504 ALG10B 0.4 5.98 0.31 5.8e-9 Drug-induced liver injury (flucloxacillin); CRC cis rs4380275 0.965 rs4315562 chr2:772723 A/G cg27237671 chr2:676223 TMEM18 -0.43 -6.11 -0.32 2.76e-9 Adverse response to chemotherapy (neutropenia/leucopenia) (doxorubicin); CRC cis rs2108225 0.837 rs6958729 chr7:107451211 A/G cg18560240 chr7:107437656 SLC26A3 0.65 10.01 0.48 8.83e-21 Ulcerative colitis; CRC cis rs9462027 0.606 rs2814984 chr6:34597513 T/C cg07306190 chr6:34760872 UHRF1BP1 -0.35 -6.2 -0.32 1.66e-9 Systemic lupus erythematosus; CRC trans rs2303319 0.504 rs56260047 chr2:162497225 G/T cg22988483 chr14:93581567 ITPK1 -0.66 -6.08 -0.32 3.27e-9 Cognitive function; CRC trans rs10139154 0.793 rs229227 chr14:31008191 T/G cg18753625 chr19:36705707 ZNF565;ZNF146 -0.43 -6.16 -0.32 2.07e-9 Amyotrophic lateral sclerosis; CRC cis rs6076065 0.723 rs761726 chr20:23401481 G/C cg11657817 chr20:23433608 CST11 0.44 6.44 0.33 4.36e-10 Facial morphology (factor 15, philtrum width); CRC cis rs780096 0.546 rs2911712 chr2:27626945 A/T cg17158414 chr2:27665306 KRTCAP3 -0.29 -6.23 -0.32 1.45e-9 Total body bone mineral density; CRC cis rs1552244 0.938 rs66915020 chr3:10110174 A/G cg16606324 chr3:10149918 C3orf24 0.67 9.13 0.45 6.91e-18 Alzheimer's disease; CRC cis rs3741151 0.773 rs11235770 chr11:73184002 C/T cg17517138 chr11:73019481 ARHGEF17 0.55 5.75 0.3 1.99e-8 GIP levels in response to oral glucose tolerance test (120 minutes); CRC cis rs7617480 0.648 rs10865953 chr3:48759562 C/T cg07636037 chr3:49044803 WDR6 0.76 9.28 0.46 2.33e-18 Subjective well-being (multi-trait analysis);Menarche (age at onset); CRC trans rs7395662 0.794 rs11511967 chr11:48820453 C/T cg21153622 chr11:89784906 NA -0.49 -7.79 -0.39 9.13e-14 HDL cholesterol; CRC cis rs4716602 0.573 rs34810003 chr7:156160883 T/C cg16983916 chr7:156159713 NA -0.39 -6.9 -0.36 2.65e-11 Anti-saccade response; CRC cis rs1552244 0.935 rs4441636 chr3:10083876 G/A cg16606324 chr3:10149918 C3orf24 0.73 9.68 0.47 1.16e-19 Alzheimer's disease; CRC cis rs7552404 0.924 rs3818855 chr1:76198785 C/T cg10523679 chr1:76189770 ACADM 0.86 13.12 0.59 6.23e-32 Blood metabolite levels;Acylcarnitine levels; CRC cis rs6032067 0.777 rs13038342 chr20:43800232 C/T cg10761708 chr20:43804764 PI3 0.47 5.7 0.3 2.68e-8 Blood protein levels; CRC cis rs6933660 0.676 rs3757316 chr6:151774339 A/G cg14416726 chr6:151773293 C6orf211;RMND1 0.59 8.52 0.43 5.8e-16 Menarche (age at onset); CRC cis rs10504229 1.000 rs114312649 chr8:58182539 C/G cg24829409 chr8:58192753 C8orf71 -0.68 -11.34 -0.53 2.27e-25 Developmental language disorder (linguistic errors); CRC trans rs1455244 0.700 rs7229302 chr18:11508904 G/T cg06659169 chr22:20748430 ZNF74 0.38 6.18 0.32 1.86e-9 Schizophrenia; CRC cis rs1862618 0.620 rs189695 chr5:56225769 T/C cg18230493 chr5:56204884 C5orf35 -0.59 -8.63 -0.43 2.72e-16 Initial pursuit acceleration; CRC cis rs10504229 0.728 rs72650861 chr8:58153273 T/C cg22535103 chr8:58192502 C8orf71 -0.68 -8.37 -0.42 1.72e-15 Developmental language disorder (linguistic errors); CRC cis rs804280 0.525 rs1004712 chr8:11622293 C/T cg12395012 chr8:11607386 GATA4 -0.43 -6.65 -0.34 1.21e-10 Myopia (pathological); CRC cis rs2013441 1.000 rs4588033 chr17:20029901 C/G cg13482628 chr17:19912719 NA -0.42 -6.43 -0.33 4.61e-10 Obesity-related traits; CRC cis rs6951245 1.000 rs79765398 chr7:1073764 A/G cg08132940 chr7:1081526 C7orf50 -0.54 -5.65 -0.3 3.48e-8 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs11098499 0.866 rs72676074 chr4:120359841 A/C cg09307838 chr4:120376055 NA 0.71 10.91 0.52 7.6e-24 Corneal astigmatism; CRC cis rs3106136 0.609 rs72665612 chr4:95101183 T/G cg11021082 chr4:95130006 SMARCAD1 -0.43 -6.16 -0.32 2.15e-9 Capecitabine sensitivity; CRC cis rs62064224 0.512 rs9912766 chr17:30712780 A/G cg18200150 chr17:30822561 MYO1D 0.44 8.52 0.43 5.79e-16 Schizophrenia; CRC cis rs7493 1.000 rs12026 chr7:95041016 G/C cg21856205 chr7:94953877 PON1 -0.49 -6.31 -0.33 8.83e-10 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs4243830 0.737 rs11122085 chr1:6597861 T/C cg05709478 chr1:6581295 PLEKHG5 0.58 6.34 0.33 7.63e-10 Body mass index; CRC cis rs2836974 0.899 rs34176878 chr21:40548855 C/A cg17971929 chr21:40555470 PSMG1 0.81 11.54 0.54 4.38e-26 Cognitive function; CRC cis rs11764590 0.694 rs2056477 chr7:2079744 G/C cg23378565 chr7:2036160 MAD1L1 -0.37 -5.84 -0.31 1.22e-8 Neuroticism; CRC cis rs13108904 0.840 rs3915420 chr4:1260337 T/C cg05665937 chr4:1216051 CTBP1 0.4 5.9 0.31 9.18e-9 Obesity-related traits; CRC cis rs921968 0.519 rs72966020 chr2:219642620 C/G cg02176678 chr2:219576539 TTLL4 -0.57 -9.02 -0.45 1.59e-17 Mean corpuscular hemoglobin concentration; CRC cis rs10256972 0.504 rs2949178 chr7:1209925 T/C cg26608667 chr7:1196370 ZFAND2A 0.42 6.86 0.35 3.4e-11 Longevity;Endometriosis; CRC cis rs763121 0.925 rs1056661 chr22:39080245 A/G cg06544989 chr22:39130855 UNC84B 0.48 7.94 0.4 3.16e-14 Menopause (age at onset); CRC trans rs8123881 0.733 rs7268466 chr20:15810676 C/T cg15035382 chr19:40728255 CNTD2 -0.5 -6.17 -0.32 2.04e-9 Body mass index; CRC cis rs780096 0.546 rs715326 chr2:27725761 A/G cg12000995 chr2:27665139 KRTCAP3 0.3 6.3 0.33 9.66e-10 Total body bone mineral density; CRC cis rs13256369 1.000 rs883648 chr8:8569521 A/G cg18904891 chr8:8559673 CLDN23 0.52 7.01 0.36 1.37e-11 Obesity-related traits; CRC cis rs7647973 0.580 rs35218722 chr3:49275805 A/G cg20833759 chr3:49053208 WDR6;DALRD3 0.38 6.28 0.33 1.06e-9 Menarche (age at onset); CRC trans rs1656966 1.000 rs1656966 chr3:186466252 C/T cg12027761 chr17:38279750 MSL1 0.4 6.01 0.31 4.93e-9 Myopia (pathological); CRC cis rs2688608 0.592 rs7909544 chr10:75484004 G/C cg16540259 chr10:75572220 NDST2 0.39 6.03 0.32 4.31e-9 Inflammatory bowel disease; CRC trans rs6951245 1.000 rs74366004 chr7:1088630 A/C cg13565492 chr6:43139072 SRF -0.71 -7.12 -0.37 7.03e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg18040181 chr10:76588616 MYST4 -0.41 -6.1 -0.32 2.9e-9 Liver disease severity in Alagille syndrome; CRC trans rs2797160 0.967 rs984041 chr6:126021328 A/T cg05039488 chr6:79577232 IRAK1BP1 0.5 7.47 0.38 7.24e-13 Endometrial cancer; CRC cis rs4409675 0.576 rs12062621 chr1:28230404 A/G cg23691781 chr1:28212827 C1orf38 0.31 7.17 0.37 4.98e-12 Corneal astigmatism; CRC cis rs13108904 0.901 rs1680073 chr4:1280337 G/A cg02018176 chr4:1364513 KIAA1530 -0.42 -7.2 -0.37 4.18e-12 Obesity-related traits; CRC cis rs926938 0.584 rs360607 chr1:115392401 C/A cg12756093 chr1:115239321 AMPD1 0.52 7.97 0.4 2.59e-14 Autism; CRC cis rs644799 0.625 rs1255175 chr11:95471186 G/A cg03916912 chr11:95522834 CEP57;FAM76B 0.56 8.67 0.43 2e-16 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs6951245 0.580 rs78894484 chr7:1138721 T/G cg18402987 chr7:1209562 NA 0.51 6.1 0.32 3.06e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs66887589 0.720 rs11724758 chr4:120239878 G/A cg09307838 chr4:120376055 NA 0.56 8.74 0.43 1.19e-16 Diastolic blood pressure; CRC cis rs9715521 0.867 rs7437815 chr4:59826005 T/C cg11281224 chr4:60001000 NA -0.38 -5.61 -0.3 4.32e-8 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs9660992 0.512 rs12123773 chr1:205122420 C/G cg00857998 chr1:205179979 DSTYK 0.47 6.4 0.33 5.21e-10 Mean corpuscular volume;Mean platelet volume; CRC cis rs763121 0.853 rs2072798 chr22:39148483 G/A cg06022373 chr22:39101656 GTPBP1 0.8 12.31 0.56 6.48e-29 Menopause (age at onset); CRC cis rs7659604 0.728 rs3924987 chr4:122689784 G/T cg20573242 chr4:122745356 CCNA2 0.51 7.28 0.37 2.4e-12 Type 2 diabetes; CRC cis rs1005277 0.579 rs1740735 chr10:38497777 A/C cg00409905 chr10:38381863 ZNF37A -0.62 -10.16 -0.49 2.77e-21 Extrinsic epigenetic age acceleration; CRC cis rs7959452 0.649 rs4761239 chr12:69776886 T/A cg14784868 chr12:69753453 YEATS4 0.83 14.13 0.61 9.37e-36 Blood protein levels; CRC cis rs514406 0.627 rs485128 chr1:53344583 T/C cg27535305 chr1:53392650 SCP2 -0.41 -7.36 -0.38 1.47e-12 Monocyte count; CRC cis rs208520 0.690 rs207114 chr6:66791703 C/T cg07460842 chr6:66804631 NA -1.1 -14.67 -0.63 7.8e-38 Exhaled nitric oxide output; CRC cis rs9322193 0.923 rs10782315 chr6:150064229 T/C cg04369109 chr6:150039330 LATS1 -0.42 -5.79 -0.3 1.6e-8 Lung cancer; CRC cis rs6968419 0.714 rs12666168 chr7:115856681 T/C cg02561103 chr7:115862891 TES -0.43 -6.42 -0.33 4.78e-10 Intraocular pressure; CRC cis rs2243480 1.000 rs4145008 chr7:65647511 T/G cg18252515 chr7:66147081 NA 1.23 14.37 0.62 1.07e-36 Diabetic kidney disease; CRC cis rs172166 0.543 rs1150691 chr6:28168033 A/G cg03623178 chr6:28175578 NA 0.7 10.38 0.5 5.15e-22 Cardiac Troponin-T levels; CRC cis rs3820068 0.603 rs35509554 chr1:15993514 C/T cg24675056 chr1:15929824 NA 0.53 6.94 0.36 2.04e-11 Systolic blood pressure; CRC trans rs916888 0.773 rs1378358 chr17:44787312 C/T cg22433210 chr17:43662623 NA 1.01 10.36 0.5 5.9e-22 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs4888262 0.508 rs4462623 chr16:74692426 C/T cg01733217 chr16:74700730 RFWD3 0.79 12.05 0.55 6.17e-28 Testicular germ cell tumor; CRC trans rs2055729 0.677 rs6601389 chr8:9740636 C/T cg08975724 chr8:8085496 FLJ10661 0.49 6.52 0.34 2.66e-10 Multiple myeloma (hyperdiploidy); CRC cis rs875971 1.000 rs6958484 chr7:65599446 G/A cg18876405 chr7:65276391 NA -0.52 -8.94 -0.44 2.87e-17 Aortic root size; CRC cis rs9911578 1.000 rs6503866 chr17:56619581 C/T cg05425664 chr17:57184151 TRIM37 0.51 8.17 0.41 6.81e-15 Intelligence (multi-trait analysis); CRC cis rs1552244 0.882 rs36006511 chr3:10054191 C/T cg08888203 chr3:10149979 C3orf24 0.65 8.61 0.43 3.07e-16 Alzheimer's disease; CRC cis rs16867335 1.000 rs11899423 chr2:181483750 C/A cg23363182 chr2:181467187 NA -0.48 -6.66 -0.34 1.13e-10 Survival in rectal cancer; CRC cis rs2197308 0.692 rs67352173 chr12:37906912 A/T cg26384229 chr12:38710491 ALG10B 0.65 8.96 0.44 2.52e-17 Morning vs. evening chronotype; CRC cis rs17376456 0.825 rs13182631 chr5:93115701 A/G cg21475434 chr5:93447410 FAM172A 0.71 6.8 0.35 4.84e-11 Diabetic retinopathy; CRC trans rs6550704 0.687 rs9865314 chr3:22634337 A/G cg08273200 chr1:39338480 MYCBP -0.43 -6.32 -0.33 8.32e-10 Daytime sleep phenotypes; CRC cis rs832540 0.629 rs10055224 chr5:56081201 C/T cg03609598 chr5:56110824 MAP3K1 0.46 6.36 0.33 6.84e-10 Coronary artery disease; CRC trans rs4672229 0.523 rs2678917 chr2:58120553 A/T cg20814774 chr4:10467319 NA 0.3 6.03 0.32 4.34e-9 Hirschsprung disease; CRC cis rs4713118 0.568 rs9468213 chr6:27706180 G/A cg15845792 chr6:28175446 NA 0.59 8.34 0.42 2.09e-15 Parkinson's disease; CRC cis rs741668 0.759 rs12428399 chr13:46634939 C/G cg06018095 chr13:46550134 ZC3H13 0.41 5.9 0.31 8.82e-9 Cerebrospinal fluid clusterin levels; CRC cis rs60871478 0.636 rs73045423 chr7:893952 G/A cg13844804 chr7:814759 HEATR2 -0.55 -5.81 -0.3 1.49e-8 Cerebrospinal P-tau181p levels; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg14634336 chr6:111804804 REV3L 0.52 7.59 0.39 3.38e-13 Response to antipsychotic treatment; CRC trans rs9929218 0.953 rs17772411 chr16:68810923 T/C cg04657470 chr2:198365150 HSPE1;HSPD1 -0.82 -11.5 -0.54 5.89e-26 Colorectal cancer; CRC cis rs1023500 0.573 rs6002592 chr22:42476754 A/C cg04733989 chr22:42467013 NAGA -0.6 -9.11 -0.45 8.21e-18 Schizophrenia; CRC cis rs9435341 0.762 rs2878349 chr1:107549245 G/A cg09367891 chr1:107599246 PRMT6 0.59 8.67 0.43 1.99e-16 Facial morphology (factor 21, depth of nasal alae); CRC cis rs9814567 0.712 rs9838119 chr3:134331980 C/T cg06109529 chr3:134205091 CEP63;ANAPC13 -0.67 -9.58 -0.47 2.53e-19 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs28386778 0.901 rs2665855 chr17:61965143 A/G cg23090583 chr17:61904693 PSMC5;FTSJ3 1.02 17.84 0.7 2.77e-50 Prudent dietary pattern; CRC cis rs7945705 0.902 rs11042088 chr11:8843515 T/A cg21881798 chr11:8931708 C11orf17;ST5 0.55 8.03 0.4 1.71e-14 Hemoglobin concentration; CRC cis rs1577917 0.883 rs12214536 chr6:86790310 G/A cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.49 -6.54 -0.34 2.29e-10 Response to antipsychotic treatment; CRC cis rs7927771 0.864 rs11600581 chr11:47448497 T/C cg18512352 chr11:47633146 NA -0.39 -7.66 -0.39 2.06e-13 Subjective well-being; CRC trans rs800082 1.000 rs62275526 chr3:144291707 G/A cg24215973 chr2:240111563 HDAC4 -0.51 -6.91 -0.36 2.56e-11 Smoking behavior; CRC cis rs11229555 0.645 rs7116007 chr11:58218701 C/T cg15696309 chr11:58395628 NA -0.91 -11.54 -0.54 4.09e-26 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; CRC cis rs735539 1.000 rs6490606 chr13:21285096 C/G cg04906043 chr13:21280425 IL17D 0.48 7.72 0.39 1.4e-13 Dental caries; CRC cis rs2257205 0.667 rs8071942 chr17:56778271 T/C cg25885038 chr17:56607967 SEPT4 -0.52 -5.71 -0.3 2.5e-8 Pancreatic cancer; CRC cis rs12541635 1.000 rs1896918 chr8:107090500 G/A cg10147462 chr8:107024639 NA -0.36 -6.12 -0.32 2.68e-9 Age of smoking initiation; CRC cis rs6761276 0.780 rs12477867 chr2:113835919 C/A cg09040174 chr2:113837401 NA 0.64 10.17 0.49 2.58e-21 Protein quantitative trait loci; CRC cis rs13315871 0.929 rs11717783 chr3:58267642 A/T cg20936604 chr3:58311152 NA -0.59 -5.66 -0.3 3.23e-8 Cholesterol, total; CRC cis rs7923609 0.936 rs10761778 chr10:65273782 A/G cg08743896 chr10:65200160 JMJD1C -0.42 -5.94 -0.31 7.27e-9 Educational attainment;Liver enzyme levels (alkaline phosphatase); CRC cis rs875971 0.862 rs2088655 chr7:65795711 T/C cg18252515 chr7:66147081 NA 0.42 5.93 0.31 7.79e-9 Aortic root size; CRC cis rs929354 0.772 rs6459741 chr7:157014553 G/T cg17757837 chr7:157058334 UBE3C 0.76 12.9 0.58 4.36e-31 Body mass index; CRC cis rs9911578 0.935 rs2302189 chr17:56584205 A/C cg05425664 chr17:57184151 TRIM37 0.52 8.27 0.41 3.45e-15 Intelligence (multi-trait analysis); CRC trans rs6600671 1.000 rs4844380 chr1:121193620 A/T cg09829573 chr1:144692074 NBPF9 -0.42 -6.26 -0.33 1.23e-9 Hip geometry; CRC cis rs9372498 0.536 rs72954806 chr6:118899965 C/G cg15382696 chr6:118971807 C6orf204 0.58 7.38 0.38 1.29e-12 Diastolic blood pressure; CRC cis rs698833 0.926 rs1067353 chr2:44666626 G/A cg04920474 chr2:44395004 PPM1B 0.38 5.63 0.3 3.85e-8 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; CRC cis rs7613875 0.620 rs17657664 chr3:50032008 T/G cg24308560 chr3:49941425 MST1R -0.44 -6.81 -0.35 4.69e-11 Body mass index; CRC cis rs12760731 0.720 rs12060844 chr1:178280816 T/C cg00404053 chr1:178313656 RASAL2 0.81 9.76 0.47 6.06e-20 Obesity-related traits; CRC cis rs1008375 1.000 rs6846238 chr4:17629939 A/G cg02297831 chr4:17616191 MED28 0.44 5.87 0.31 1.05e-8 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs9859260 0.710 rs419068 chr3:195782176 C/T cg12923728 chr3:195709715 SDHAP1 0.48 6.54 0.34 2.35e-10 Mean corpuscular volume; CRC cis rs7937682 0.921 rs1944119 chr11:111436387 A/G cg19812747 chr11:111475976 SIK2 0.49 7.26 0.37 2.84e-12 Primary sclerosing cholangitis; CRC cis rs6499255 0.951 rs3743673 chr16:69711311 A/T cg15192750 chr16:69999425 NA 0.6 8.04 0.41 1.59e-14 IgE levels; CRC cis rs9296404 1 rs9296404 chr6:42925803 T/C cg02359409 chr6:42947317 PEX6 -0.69 -11.41 -0.53 1.28e-25 Plasma homocysteine levels (post-methionine load test); CRC cis rs7412746 0.611 rs10888391 chr1:150729983 G/A cg15448220 chr1:150897856 SETDB1 0.52 7.3 0.37 2.16e-12 Melanoma; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg26612175 chr1:100503886 HIAT1 0.44 6.36 0.33 6.88e-10 Intelligence (multi-trait analysis); CRC cis rs875971 0.862 rs10261398 chr7:65750164 A/G cg00343986 chr7:65444356 GUSB -0.4 -5.68 -0.3 2.97e-8 Aortic root size; CRC cis rs4563143 0.675 rs55884228 chr19:29243897 G/T cg14983838 chr19:29218262 NA 0.46 6.76 0.35 6.47e-11 Methadone dose in opioid dependence; CRC cis rs3796619 1.000 rs4045481 chr4:1090625 C/T cg27284194 chr4:1044797 NA 0.38 5.92 0.31 7.93e-9 Recombination rate (males); CRC cis rs1971762 0.563 rs7958775 chr12:54077556 T/C cg06632207 chr12:54070931 ATP5G2 0.41 7.03 0.36 1.18e-11 Height; CRC cis rs597539 0.617 rs598353 chr11:68635770 C/A cg21963583 chr11:68658836 MRPL21 0.59 10.65 0.51 6e-23 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs9325144 0.600 rs10748442 chr12:38732939 A/T cg13010199 chr12:38710504 ALG10B 0.4 5.92 0.31 8.08e-9 Morning vs. evening chronotype; CRC cis rs11098499 0.863 rs9997631 chr4:120469995 C/G cg24375607 chr4:120327624 NA 0.49 7.49 0.38 6.44e-13 Corneal astigmatism; CRC cis rs4843747 0.749 rs12102841 chr16:88072574 C/G cg03395651 chr16:88107091 BANP -0.55 -7.47 -0.38 7.24e-13 Menopause (age at onset); CRC cis rs6570726 0.791 rs407887 chr6:145843759 C/T cg13319975 chr6:146136371 FBXO30 -0.45 -6.78 -0.35 5.73e-11 Lobe attachment (rater-scored or self-reported); CRC cis rs7769051 1.000 rs7761365 chr6:133101561 T/A cg22852734 chr6:133119734 C6orf192 0.93 11.05 0.52 2.33e-24 Type 2 diabetes nephropathy; CRC trans rs9650657 0.613 rs877116 chr8:10712945 G/T cg06636001 chr8:8085503 FLJ10661 -0.45 -6.43 -0.33 4.39e-10 Neuroticism; CRC trans rs9929218 1.000 rs11865026 chr16:68774283 A/G cg04657470 chr2:198365150 HSPE1;HSPD1 -0.96 -14.5 -0.62 3.44e-37 Colorectal cancer; CRC cis rs7131987 0.641 rs2015599 chr12:29435480 G/A cg09582351 chr12:29534625 ERGIC2 -0.3 -6.43 -0.33 4.54e-10 QT interval; CRC cis rs7527798 0.592 rs6667238 chr1:207822856 G/A cg21110645 chr1:207815933 NA -0.41 -6.45 -0.34 3.95e-10 Erythrocyte sedimentation rate; CRC cis rs477895 0.838 rs35090903 chr11:64000598 C/T cg18375707 chr11:64034959 PLCB3 0.46 6.46 0.34 3.81e-10 Mean platelet volume; CRC cis rs9303401 0.659 rs17222523 chr17:56620501 A/G cg02118635 chr17:56770003 RAD51C;TEX14 0.8 9.95 0.48 1.48e-20 Cognitive test performance; CRC cis rs4665809 0.525 rs10865402 chr2:26535383 A/G cg26119090 chr2:26468346 HADHA;HADHB -0.54 -6.77 -0.35 6.01e-11 Gut microbiome composition (summer); CRC cis rs10883723 0.810 rs2296585 chr10:104245549 C/T cg11453585 chr10:104263688 ACTR1A;SUFU 0.9 16.54 0.67 3.69e-45 Allergic disease (asthma, hay fever or eczema); CRC trans rs10802346 0.545 rs10924568 chr1:246385482 C/A cg13514129 chr1:39547527 MACF1 0.64 9.77 0.47 6e-20 Fractional exhaled nitric oxide (childhood); CRC trans rs2553218 0.690 rs8032415 chr15:54851945 A/G cg26235292 chr4:99850587 EIF4E 0.52 6.99 0.36 1.57e-11 Immune response to smallpox vaccine (IL-6); CRC cis rs950173 1.000 rs13000153 chr2:172586067 A/G cg13550731 chr2:172543902 DYNC1I2 -0.76 -6.13 -0.32 2.54e-9 Hippocampal volume; CRC cis rs7727544 0.647 rs72793280 chr5:131562900 C/T cg22638593 chr5:131593259 PDLIM4 0.35 6.29 0.33 1.02e-9 Blood metabolite levels; CRC cis rs644799 0.542 rs10831416 chr11:95467220 A/G cg03916912 chr11:95522834 CEP57;FAM76B 0.66 10.08 0.49 5.15e-21 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs208520 1.000 rs72882086 chr6:66976671 G/A cg07460842 chr6:66804631 NA 0.92 11.38 0.53 1.56e-25 Exhaled nitric oxide output; CRC cis rs9399137 0.507 rs4896128 chr6:135349756 A/G cg22676075 chr6:135203613 NA -0.58 -8.76 -0.43 1.08e-16 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; CRC cis rs7119 0.679 rs12902698 chr15:77809010 A/C cg10437265 chr15:77819839 NA 0.68 12.43 0.57 2.41e-29 Type 2 diabetes; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg19409588 chr3:32148040 GPD1L 0.44 6.21 0.32 1.61e-9 Anxiety disorder; CRC cis rs7937682 0.575 rs7107213 chr11:111750430 A/G cg19812747 chr11:111475976 SIK2 0.42 6.19 0.32 1.77e-9 Primary sclerosing cholangitis; CRC cis rs3026445 0.791 rs7309141 chr12:110587637 G/A cg12870014 chr12:110450643 ANKRD13A 0.44 6.97 0.36 1.73e-11 QT interval; CRC cis rs9747201 0.894 rs9944398 chr17:80177439 A/G cg09264619 chr17:80180166 NA -0.49 -6.9 -0.36 2.63e-11 Peripheral arterial disease (traffic-related air pollution interaction); CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg24132527 chr5:140019269 TMCO6 -0.38 -5.97 -0.31 6.24e-9 Myopia (pathological); CRC cis rs9868809 0.881 rs13076269 chr3:48675925 T/C cg07636037 chr3:49044803 WDR6 -0.64 -6.24 -0.33 1.32e-9 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; CRC cis rs11122272 0.670 rs2474632 chr1:231484361 C/T cg06096015 chr1:231504339 EGLN1 0.43 6.49 0.34 3.21e-10 Hemoglobin concentration; CRC cis rs8067545 0.750 rs11868084 chr17:19992717 A/G cg13482628 chr17:19912719 NA 0.46 7.55 0.38 4.46e-13 Schizophrenia; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg25362248 chr1:31192015 MATN1 0.4 6.02 0.31 4.78e-9 Intelligence (multi-trait analysis); CRC cis rs60871478 0.588 rs73043546 chr7:857513 C/G cg05535760 chr7:792225 HEATR2 -0.98 -10.6 -0.5 8.96e-23 Cerebrospinal P-tau181p levels; CRC cis rs172166 0.543 rs1150691 chr6:28168033 A/G cg21251018 chr6:28226885 NKAPL 0.55 9.07 0.45 1.12e-17 Cardiac Troponin-T levels; CRC cis rs1448094 0.845 rs7132262 chr12:86346304 C/T cg02569458 chr12:86230093 RASSF9 0.47 7.98 0.4 2.42e-14 Major depressive disorder; CRC cis rs6933660 0.720 rs6913515 chr6:151753470 G/C cg14262678 chr6:151773367 RMND1;C6orf211 0.49 7.9 0.4 4.1e-14 Menarche (age at onset); CRC cis rs12701220 0.895 rs12534778 chr7:1065861 C/T cg02733842 chr7:1102375 C7orf50 0.78 9.08 0.45 1.02e-17 Bronchopulmonary dysplasia; CRC cis rs540254 0.578 rs12117689 chr1:160782100 C/T cg20255094 chr1:160771763 LY9 0.49 6.34 0.33 7.78e-10 Blood protein levels; CRC cis rs6973256 0.583 rs2430768 chr7:133340287 T/C cg10665199 chr7:133106180 EXOC4 -0.45 -6.92 -0.36 2.3e-11 Intelligence (multi-trait analysis); CRC cis rs6665290 0.669 rs7552783 chr1:227174145 T/C cg10327440 chr1:227177885 CDC42BPA -0.94 -18.72 -0.72 9.63e-54 Myeloid white cell count; CRC cis rs727505 0.866 rs17327181 chr7:124720303 A/G cg23710748 chr7:124431027 NA -0.72 -12.4 -0.56 3e-29 Lewy body disease; CRC trans rs2243480 1.000 rs67536397 chr7:65947917 G/A cg10756647 chr7:56101905 PSPH 0.74 7.52 0.38 5.22e-13 Diabetic kidney disease; CRC cis rs7727544 0.735 rs274559 chr5:131720070 A/G cg07395648 chr5:131743802 NA 0.38 5.92 0.31 7.96e-9 Blood metabolite levels; CRC cis rs1552244 1.000 rs76041173 chr3:10078695 G/T cg00166722 chr3:10149974 C3orf24 0.71 9.45 0.46 6.66e-19 Alzheimer's disease; CRC cis rs6674176 0.597 rs3762422 chr1:44400532 T/A cg15962314 chr1:44399869 ARTN 0.32 6.23 0.32 1.41e-9 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Cognitive ability; CRC trans rs7395662 0.571 rs4882020 chr11:48615658 C/T cg03929089 chr4:120376271 NA -0.46 -6.52 -0.34 2.68e-10 HDL cholesterol; CRC cis rs1448094 0.967 rs7961782 chr12:86326461 T/C cg02569458 chr12:86230093 RASSF9 0.37 6.47 0.34 3.47e-10 Major depressive disorder; CRC cis rs354225 0.608 rs168505 chr2:54920968 C/T cg26097391 chr2:54893211 SPTBN1 0.51 8.39 0.42 1.5e-15 Schizophrenia; CRC cis rs7258465 0.931 rs7249020 chr19:18608147 A/G cg10790698 chr19:18539756 SSBP4 -0.44 -8.44 -0.42 1e-15 Breast cancer; CRC cis rs3824867 0.879 rs10742806 chr11:47456226 T/A cg05585544 chr11:47624801 NA -0.4 -6.36 -0.33 6.58e-10 Mean corpuscular hemoglobin; CRC cis rs11098499 0.818 rs12498599 chr4:120468503 C/T cg24375607 chr4:120327624 NA 0.48 7.45 0.38 8.51e-13 Corneal astigmatism; CRC cis rs6502050 0.835 rs3924780 chr17:80112978 G/A cg22110888 chr17:80059540 CCDC57 0.4 6.44 0.33 4.17e-10 Life satisfaction; CRC cis rs800160 0.777 rs11022291 chr11:2345621 T/C cg09785033 chr11:2336066 TSPAN32 -0.48 -5.72 -0.3 2.45e-8 Bacteremia; CRC cis rs17270561 0.609 rs9379789 chr6:25745579 A/G cg17691542 chr6:26056736 HIST1H1C 0.72 9.24 0.45 3.07e-18 Iron status biomarkers; CRC cis rs870825 0.616 rs28618216 chr4:185648998 T/C cg04058563 chr4:185651563 MLF1IP 0.72 9.3 0.46 2.04e-18 Blood protein levels; CRC cis rs769267 0.965 rs735273 chr19:19385411 T/C cg03709012 chr19:19516395 GATAD2A 0.72 11.0 0.52 3.62e-24 Tonsillectomy; CRC cis rs7216064 1.000 rs6504548 chr17:65886048 T/C cg12091567 chr17:66097778 LOC651250 -0.63 -7.82 -0.4 7.34e-14 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CRC cis rs2243480 1.000 rs73142162 chr7:65374296 A/T cg18252515 chr7:66147081 NA -1.14 -12.94 -0.58 3.11e-31 Diabetic kidney disease; CRC cis rs35110281 0.744 rs162395 chr21:44945759 T/C cg04455712 chr21:45112962 RRP1B 0.42 7.88 0.4 4.92e-14 Mean corpuscular volume; CRC cis rs1552244 1.000 rs55822690 chr3:10128003 A/G cg18598329 chr3:10140678 FANCD2;C3orf24 -0.91 -12.45 -0.57 2.12e-29 Alzheimer's disease; CRC cis rs9916302 0.851 rs12936646 chr17:37647450 A/T cg07936489 chr17:37558343 FBXL20 -0.76 -11.31 -0.53 2.72e-25 Glomerular filtration rate (creatinine); CRC cis rs1448094 0.533 rs4412812 chr12:86151238 G/A cg18827107 chr12:86230957 RASSF9 0.38 6.0 0.31 5.1e-9 Major depressive disorder; CRC cis rs4665809 0.938 rs4665822 chr2:26312555 C/G cg04944784 chr2:26401820 FAM59B -0.6 -7.74 -0.39 1.24e-13 Gut microbiome composition (summer); CRC cis rs9302690 0.557 rs223869 chr16:57494992 C/A cg16753122 chr16:57506917 DOK4 0.51 5.79 0.3 1.68e-8 Blood protein levels; CRC cis rs11148252 0.875 rs4884452 chr13:52949784 C/T cg02158880 chr13:53174818 NA -0.44 -6.62 -0.34 1.46e-10 Lewy body disease; CRC cis rs17666538 0.792 rs1669715 chr8:593641 T/C cg02524346 chr8:600233 NA 0.96 9.4 0.46 9.56e-19 IgG glycosylation; CRC cis rs7647973 0.593 rs4855885 chr3:49690199 G/A cg13072238 chr3:49761600 GMPPB -0.52 -5.7 -0.3 2.65e-8 Menarche (age at onset); CRC cis rs6604026 0.740 rs10874746 chr1:93323971 A/G cg17283838 chr1:93427260 FAM69A -0.45 -6.13 -0.32 2.52e-9 Multiple sclerosis; CRC cis rs2836974 0.590 rs11911822 chr21:40607843 C/T cg17971929 chr21:40555470 PSMG1 -0.73 -11.32 -0.53 2.66e-25 Cognitive function; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg20284698 chr3:48956327 C3orf71;ARIH2 -0.43 -7.18 -0.37 4.57e-12 Myopia (pathological); CRC cis rs7666738 0.830 rs1813642 chr4:98852225 G/A cg05340658 chr4:99064831 C4orf37 0.59 8.89 0.44 3.97e-17 Colonoscopy-negative controls vs population controls; CRC cis rs9858542 0.953 rs9853683 chr3:49512588 A/G cg07274523 chr3:49395745 GPX1 0.47 6.4 0.33 5.33e-10 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC trans rs8002861 0.664 rs895266 chr13:44461179 T/C cg17145862 chr1:211918768 LPGAT1 0.57 9.46 0.46 6.05e-19 Leprosy; CRC cis rs13191362 0.872 rs35672319 chr6:163245464 C/A cg06582575 chr6:163149167 PACRG;PARK2 0.69 8.74 0.43 1.19e-16 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs4731207 0.596 rs10500098 chr7:124658055 C/G cg23710748 chr7:124431027 NA -0.39 -6.17 -0.32 1.99e-9 Cutaneous malignant melanoma; CRC cis rs854765 0.505 rs4924832 chr17:17897739 A/G cg16928487 chr17:17741425 SREBF1 -0.48 -8.44 -0.42 1.04e-15 Total body bone mineral density; CRC trans rs8035957 1.000 rs4924273 chr15:38846738 C/G cg15208630 chr4:166034127 TMEM192 -0.52 -6.5 -0.34 2.97e-10 Type 1 diabetes; CRC cis rs4713118 0.869 rs9461401 chr6:27703291 G/A cg25164649 chr6:28176230 NA 0.58 8.19 0.41 5.97e-15 Parkinson's disease; CRC cis rs6815814 0.799 rs11466640 chr4:38778903 A/G cg06935464 chr4:38784597 TLR10 -0.57 -5.62 -0.3 4.13e-8 Breast cancer; CRC cis rs12220238 1.000 rs7909664 chr10:75869754 T/C cg19889307 chr10:75911429 ADK;AP3M1 0.63 6.28 0.33 1.09e-9 Soluble interleukin-2 receptor subunit alpha; CRC cis rs73001065 0.591 rs56273306 chr19:19621004 T/C cg03709012 chr19:19516395 GATAD2A 0.76 6.04 0.32 4.1e-9 LDL cholesterol; CRC cis rs13108904 0.870 rs4974545 chr4:1271923 C/T cg05665937 chr4:1216051 CTBP1 0.43 6.32 0.33 8.55e-10 Obesity-related traits; CRC cis rs8180040 1.000 rs295449 chr3:47375955 G/A cg02527881 chr3:46936655 PTH1R -0.4 -7.66 -0.39 2.09e-13 Colorectal cancer; CRC cis rs10751667 0.643 rs10794343 chr11:925493 C/T cg23136738 chr11:925521 AP2A2 -0.42 -7.03 -0.36 1.17e-11 Alzheimer's disease (late onset); CRC cis rs7584330 0.744 rs10929234 chr2:238380034 C/G cg14458575 chr2:238380390 NA -0.88 -16.25 -0.67 5.49e-44 Prostate cancer; CRC trans rs1814175 0.645 rs847627 chr11:49927177 G/A cg15704280 chr7:45808275 SEPT13 -0.95 -16.82 -0.68 3.11e-46 Height; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg18642567 chr14:21755798 RPGRIP1 0.42 6.44 0.33 4.29e-10 Myopia (pathological); CRC cis rs7107174 0.681 rs11237443 chr11:78005089 C/A cg02023728 chr11:77925099 USP35 0.54 8.44 0.42 1.03e-15 Testicular germ cell tumor; CRC cis rs6545883 0.826 rs777593 chr2:61419103 C/A cg15711740 chr2:61764176 XPO1 -0.44 -5.7 -0.3 2.63e-8 Tuberculosis; CRC cis rs2228479 0.618 rs17233623 chr16:89811209 C/T cg06558623 chr16:89946397 TCF25 0.94 9.29 0.46 2.1e-18 Skin colour saturation; CRC cis rs7772486 0.623 rs9485021 chr6:146068797 A/G cg23711669 chr6:146136114 FBXO30 -0.65 -10.77 -0.51 2.23e-23 Lobe attachment (rater-scored or self-reported); CRC cis rs8050755 0.649 rs45477195 chr16:2115481 C/T cg04515572 chr16:2107413 TSC2 -0.83 -7.87 -0.4 5.11e-14 Major depressive disorder; CRC cis rs6570726 0.935 rs446242 chr6:145843866 A/G cg13319975 chr6:146136371 FBXO30 -0.38 -5.84 -0.31 1.26e-8 Lobe attachment (rater-scored or self-reported); CRC trans rs951252 0.504 rs11734405 chr4:146081096 C/T cg09765074 chr10:69634185 NA -0.45 -6.3 -0.33 9.71e-10 Hip circumference; CRC cis rs2180341 0.960 rs1964130 chr6:127677391 C/G cg24812749 chr6:127587940 RNF146 0.84 11.65 0.54 1.77e-26 Breast cancer; CRC cis rs2204008 0.807 rs11182461 chr12:38539288 T/C cg13010199 chr12:38710504 ALG10B 0.47 5.99 0.31 5.65e-9 Bladder cancer; CRC trans rs11148252 0.811 rs9535895 chr13:52765847 G/A cg18335740 chr13:41363409 SLC25A15 0.54 8.4 0.42 1.31e-15 Lewy body disease; CRC cis rs28830936 1.000 rs17734856 chr15:42045160 T/C cg17847044 chr15:42102381 MAPKBP1 -0.29 -5.98 -0.31 5.96e-9 Diastolic blood pressure; CRC cis rs921968 0.643 rs6708683 chr2:219504503 G/A cg02176678 chr2:219576539 TTLL4 0.5 7.98 0.4 2.46e-14 Mean corpuscular hemoglobin concentration; CRC cis rs9915657 0.870 rs4140903 chr17:70133771 C/T cg09344028 chr17:70110421 NA 0.44 6.71 0.35 8.63e-11 Thyroid hormone levels; CRC cis rs9733 0.596 rs7529998 chr1:150662531 C/T cg15448220 chr1:150897856 SETDB1 0.45 6.43 0.33 4.42e-10 Tonsillectomy; CRC trans rs7395662 0.963 rs8189076 chr11:48732975 C/T cg21153622 chr11:89784906 NA 0.46 7.41 0.38 1.06e-12 HDL cholesterol; CRC cis rs3733585 0.648 rs35954357 chr4:9978758 G/C cg00071950 chr4:10020882 SLC2A9 0.56 9.85 0.48 3.11e-20 Cleft plate (environmental tobacco smoke interaction); CRC cis rs2346160 0.867 rs2076005 chr6:167704944 A/C cg04673565 chr6:167680447 NA -0.33 -5.64 -0.3 3.63e-8 Parental extreme longevity (95 years and older); CRC cis rs9388451 0.626 rs1343115 chr6:126069817 C/G cg05901451 chr6:126070800 HEY2 -0.54 -9.01 -0.44 1.69e-17 Brugada syndrome; CRC trans rs453301 0.571 rs2929456 chr8:9083416 G/A cg16141378 chr3:129829833 LOC729375 0.4 6.11 0.32 2.78e-9 Joint mobility (Beighton score); CRC trans rs6550704 0.687 rs9865314 chr3:22634337 A/G cg02923393 chr16:1543003 TELO2 -0.41 -6.0 -0.31 5.26e-9 Daytime sleep phenotypes; CRC cis rs4665809 0.531 rs3892649 chr2:26457267 T/G cg22920501 chr2:26401640 FAM59B 0.85 12.21 0.56 1.54e-28 Gut microbiome composition (summer); CRC cis rs9372498 0.764 rs9320652 chr6:118720448 A/G cg18833306 chr6:118973337 C6orf204 0.49 6.19 0.32 1.83e-9 Diastolic blood pressure; CRC cis rs6908034 0.607 rs12525152 chr6:19809424 A/T cg02682789 chr6:19804855 NA 0.74 6.54 0.34 2.35e-10 Endometriosis;Deep ovarian and/or rectovaginal disease with dense adhesions; CRC cis rs4493873 1.000 rs10110267 chr8:92073814 G/A cg16814680 chr8:91681699 NA 0.42 5.94 0.31 7.25e-9 Migraine - clinic-based; CRC cis rs4919694 1.000 rs11191490 chr10:104745174 T/A cg04362960 chr10:104952993 NT5C2 1.16 10.78 0.51 2.07e-23 Arsenic metabolism; CRC cis rs6502050 0.637 rs74765203 chr17:80118223 A/G cg11859384 chr17:80120422 CCDC57 -0.37 -5.74 -0.3 2.1e-8 Life satisfaction; CRC cis rs2976388 0.590 rs7828042 chr8:143819383 A/G cg04969067 chr8:143858791 LYNX1 -0.42 -6.66 -0.34 1.17e-10 Urinary tract infection frequency; CRC cis rs13315871 0.790 rs9825431 chr3:58406694 G/C cg20936604 chr3:58311152 NA -0.75 -7.12 -0.37 6.99e-12 Cholesterol, total; CRC cis rs295140 0.546 rs842830 chr2:201131124 C/T cg23649088 chr2:200775458 C2orf69 -0.4 -5.66 -0.3 3.3e-8 QT interval; CRC trans rs6539288 0.803 rs10778517 chr12:107341664 G/T cg25190001 chr12:49371310 WNT1 -0.34 -6.09 -0.32 3.12e-9 Total body bone mineral density; CRC cis rs7927592 0.913 rs10047412 chr11:68232912 T/C cg16797656 chr11:68205561 LRP5 0.41 6.56 0.34 2.05e-10 Total body bone mineral density; CRC cis rs9648716 1.000 rs1267623 chr7:140534267 C/T cg10747023 chr7:140774559 NA 0.45 5.84 0.31 1.27e-8 Type 2 diabetes; CRC cis rs2288073 0.965 rs6545335 chr2:24422011 G/A cg06627628 chr2:24431161 ITSN2 -0.71 -9.9 -0.48 2.12e-20 Venous thromboembolism (SNP x SNP interaction); CRC cis rs4654899 0.865 rs10916951 chr1:21528835 A/G cg02927042 chr1:21476669 EIF4G3 0.52 8.28 0.42 3.07e-15 Superior frontal gyrus grey matter volume; CRC cis rs10540 0.915 rs12419209 chr11:494510 T/C cg21784768 chr11:537496 LRRC56 -0.68 -6.51 -0.34 2.8e-10 Body mass index; CRC cis rs9807989 0.839 rs10204137 chr2:102968212 A/G cg03938978 chr2:103052716 IL18RAP 0.37 6.02 0.32 4.65e-9 Asthma; CRC cis rs1707322 0.827 rs6694302 chr1:46245645 A/T cg06784218 chr1:46089804 CCDC17 0.6 10.93 0.52 6.45e-24 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC trans rs5756813 1.000 rs1074407 chr22:38156183 T/A cg19894588 chr14:64061835 NA 0.62 9.17 0.45 5.43e-18 Optic cup area;Vertical cup-disc ratio; CRC cis rs7914558 0.966 rs10786727 chr10:104698523 G/A cg15744005 chr10:104629667 AS3MT -0.35 -7.54 -0.38 4.73e-13 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs1153858 1.000 rs56806728 chr15:45637814 A/G cg10760299 chr15:45669010 GATM 0.5 7.99 0.4 2.37e-14 Homoarginine levels; CRC cis rs17345786 0.906 rs59359251 chr3:101146362 A/C cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.58 6.85 0.35 3.63e-11 Colonoscopy-negative controls vs population controls; CRC cis rs4665809 0.878 rs6748745 chr2:26364190 C/T cg26119090 chr2:26468346 HADHA;HADHB -0.7 -8.4 -0.42 1.4e-15 Gut microbiome composition (summer); CRC cis rs7666738 0.830 rs62321565 chr4:98976571 G/A cg05340658 chr4:99064831 C4orf37 0.57 8.76 0.43 1.05e-16 Colonoscopy-negative controls vs population controls; CRC cis rs6460942 0.915 rs2216050 chr7:12304073 T/C cg06484146 chr7:12443880 VWDE -0.5 -6.46 -0.34 3.71e-10 Coronary artery disease; CRC cis rs1552244 0.938 rs7652951 chr3:10063763 A/C cg00166722 chr3:10149974 C3orf24 0.65 8.86 0.44 5.13e-17 Alzheimer's disease; CRC cis rs2257205 0.588 rs7214266 chr17:56851920 C/T cg25885038 chr17:56607967 SEPT4 -0.53 -5.75 -0.3 2.07e-8 Pancreatic cancer; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg26343512 chr14:77413728 NA 0.4 6.34 0.33 7.65e-10 Liver disease severity in Alagille syndrome; CRC cis rs4713118 0.629 rs203889 chr6:28021775 T/G cg23161317 chr6:28129485 ZNF389 0.43 5.62 0.3 4.16e-8 Parkinson's disease; CRC cis rs4862750 0.872 rs9997374 chr4:187877549 T/A cg03452623 chr4:187889614 NA -0.91 -21.52 -0.76 1.01e-64 Lobe attachment (rater-scored or self-reported); CRC cis rs2303759 0.918 rs7251704 chr19:49890873 T/G cg22590775 chr19:49891494 CCDC155 0.63 8.92 0.44 3.24e-17 Multiple sclerosis; CRC cis rs1865760 1.000 rs3830057 chr6:25918510 G/T cg16482183 chr6:26056742 HIST1H1C 0.54 7.79 0.39 8.74e-14 Height; CRC cis rs853679 0.517 rs9368557 chr6:28131537 T/C cg15845792 chr6:28175446 NA 1.04 13.89 0.61 7.67e-35 Depression; CRC cis rs13082711 0.863 rs34611823 chr3:27500344 A/G cg02860705 chr3:27208620 NA 0.61 8.72 0.43 1.35e-16 Systolic blood pressure;Diastolic blood pressure;Blood pressure; CRC cis rs853679 1.000 rs1936365 chr6:28268452 C/G cg03623178 chr6:28175578 NA -0.68 -7.41 -0.38 1.1e-12 Depression; CRC cis rs4363385 0.747 rs4845330 chr1:152981505 A/G cg25856811 chr1:152973957 SPRR3 -0.25 -6.78 -0.35 5.6e-11 Inflammatory skin disease; CRC cis rs9303401 0.661 rs9902820 chr17:56637545 A/C cg12560992 chr17:57184187 TRIM37 0.57 8.41 0.42 1.23e-15 Cognitive test performance; CRC cis rs11229555 0.645 rs4579945 chr11:58190873 T/C cg15696309 chr11:58395628 NA -0.82 -10.31 -0.49 8.59e-22 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg04135372 chr2:99061383 INPP4A -0.42 -6.05 -0.32 3.86e-9 Myopia (pathological); CRC cis rs2276314 0.857 rs62101394 chr18:33592299 C/T cg19628046 chr18:33552617 C18orf21 0.49 6.68 0.35 1.02e-10 Endometriosis;Drug-induced torsades de pointes; CRC cis rs11233250 0.502 rs11233279 chr11:82412740 T/C cg17391194 chr11:82401662 NA 0.38 5.99 0.31 5.57e-9 Glioblastoma;Glioma; CRC cis rs7945718 0.535 rs7114698 chr11:12707876 C/T cg25843174 chr11:12811716 TEAD1 0.41 7.58 0.39 3.61e-13 Educational attainment (years of education); CRC cis rs2898681 0.614 rs10016904 chr4:53694296 C/A cg00338735 chr4:53728038 RASL11B 0.43 6.5 0.34 3.04e-10 Optic nerve measurement (cup area); CRC cis rs539096 0.692 rs6686238 chr1:44210253 C/G cg12908607 chr1:44402522 ARTN -0.35 -6.06 -0.32 3.77e-9 Intelligence (multi-trait analysis); CRC cis rs7666738 0.830 rs10029849 chr4:99059362 T/C cg17366294 chr4:99064904 C4orf37 0.45 7.71 0.39 1.51e-13 Colonoscopy-negative controls vs population controls; CRC cis rs736408 0.812 rs2071506 chr3:52826276 T/C cg11645453 chr3:52864694 ITIH4 0.47 8.47 0.42 8.55e-16 Bipolar disorder; CRC cis rs7552404 0.731 rs10873787 chr1:76367797 G/A cg03433033 chr1:76189801 ACADM 0.72 8.73 0.43 1.35e-16 Blood metabolite levels;Acylcarnitine levels; CRC cis rs875971 0.545 rs10950027 chr7:65634151 C/T cg05627663 chr7:65219948 SNORA22;CCT6P1 0.59 7.7 0.39 1.64e-13 Aortic root size; CRC cis rs1707322 1.000 rs1707338 chr1:46511981 T/G cg06784218 chr1:46089804 CCDC17 -0.55 -9.74 -0.47 7.37e-20 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs13108904 0.901 rs7673398 chr4:1300077 G/A cg21620606 chr4:1342894 KIAA1530 0.4 7.19 0.37 4.37e-12 Obesity-related traits; CRC trans rs2383876 0.550 rs7008962 chr8:74073416 A/G cg23880589 chr17:7826623 KCNAB3 -0.36 -6.08 -0.32 3.29e-9 Corneal curvature; CRC cis rs1728785 1.000 rs4783653 chr16:68562815 C/T cg02972257 chr16:68554789 NA -0.59 -7.34 -0.38 1.71e-12 Ulcerative colitis; CRC cis rs769267 0.930 rs1063966 chr19:19616742 G/A cg01262667 chr19:19385393 TM6SF2 0.36 5.96 0.31 6.35e-9 Tonsillectomy; CRC trans rs208520 0.909 rs9453672 chr6:66991431 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.89 10.79 0.51 1.95e-23 Exhaled nitric oxide output; CRC cis rs7639513 0.545 rs13061104 chr3:12717321 G/T cg23032965 chr3:12705835 RAF1 0.53 7.09 0.36 8.05e-12 Itch intensity from mosquito bite; CRC cis rs6921919 0.583 rs2027361 chr6:28388308 A/G cg21251018 chr6:28226885 NKAPL 0.41 6.32 0.33 8.73e-10 Autism spectrum disorder or schizophrenia; CRC trans rs11098499 0.826 rs12511640 chr4:120251248 T/C cg25214090 chr10:38739885 LOC399744 0.53 8.36 0.42 1.81e-15 Corneal astigmatism; CRC cis rs7647973 0.710 rs11130207 chr3:49611666 T/G cg13072238 chr3:49761600 GMPPB -0.54 -5.85 -0.31 1.19e-8 Menarche (age at onset); CRC cis rs10504229 0.815 rs72650877 chr8:58164510 T/C cg24829409 chr8:58192753 C8orf71 -0.62 -8.25 -0.41 3.81e-15 Developmental language disorder (linguistic errors); CRC cis rs1577917 0.958 rs4707223 chr6:86509802 A/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.53 -7.06 -0.36 9.81e-12 Response to antipsychotic treatment; CRC cis rs6860806 0.507 rs270608 chr5:131648406 C/T cg18301423 chr5:131593218 PDLIM4 0.42 6.99 0.36 1.53e-11 Breast cancer; CRC cis rs2832191 1.000 rs9984793 chr21:30486471 T/C cg24692254 chr21:30365293 RNF160 -0.65 -11.2 -0.53 7.06e-25 Dental caries; CRC cis rs4713118 0.586 rs6905516 chr6:28086478 A/G cg02683197 chr6:28174875 NA 0.85 10.27 0.49 1.16e-21 Parkinson's disease; CRC cis rs73206853 0.841 rs7959516 chr12:110622224 A/C cg12870014 chr12:110450643 ANKRD13A 0.72 7.9 0.4 4.29e-14 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC cis rs12476592 0.602 rs6546007 chr2:63724795 C/T cg10828910 chr2:63850056 LOC388955 0.49 6.08 0.32 3.33e-9 Childhood ear infection; CRC cis rs7264396 0.635 rs6060703 chr20:34529906 T/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.63 -10.48 -0.5 2.23e-22 Total cholesterol levels; CRC cis rs60871478 1.000 rs34086011 chr7:805430 C/T cg05535760 chr7:792225 HEATR2 0.8 10.57 0.5 1.09e-22 Cerebrospinal P-tau181p levels; CRC cis rs755249 0.567 rs4660751 chr1:39905873 C/T cg18385671 chr1:39797026 MACF1 -0.41 -5.84 -0.31 1.28e-8 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs763121 0.853 rs5757162 chr22:38993370 C/T cg06022373 chr22:39101656 GTPBP1 0.76 11.08 0.52 1.87e-24 Menopause (age at onset); CRC cis rs2153535 0.580 rs2327062 chr6:8453858 G/A cg07606381 chr6:8435919 SLC35B3 0.68 10.87 0.51 1.01e-23 Motion sickness; CRC cis rs2070488 1.000 rs3792528 chr3:38493303 T/C cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.91 17.04 0.68 4.14e-47 Electrocardiographic conduction measures; CRC cis rs782590 0.967 rs11125579 chr2:55739804 T/C cg18811423 chr2:55921094 PNPT1 0.78 13.76 0.6 2.41e-34 Metabolic syndrome; CRC cis rs4700695 0.841 rs706681 chr5:65317913 G/T cg21114390 chr5:65439923 SFRS12 0.59 6.91 0.36 2.5e-11 Facial morphology (factor 19); CRC cis rs1552244 0.882 rs3755782 chr3:10029305 T/C cg10729496 chr3:10149963 C3orf24 0.48 6.25 0.33 1.25e-9 Alzheimer's disease; CRC cis rs2243480 1.000 rs383402 chr7:65586653 A/C cg25985355 chr7:65971099 NA 0.5 5.91 0.31 8.43e-9 Diabetic kidney disease; CRC trans rs11088226 0.598 rs79634586 chr21:33959363 A/G cg09050820 chr6:167586206 TCP10L2 0.87 8.71 0.43 1.47e-16 Gastritis; CRC cis rs17376456 0.877 rs13173952 chr5:93307557 A/T cg21475434 chr5:93447410 FAM172A 0.79 8.22 0.41 4.73e-15 Diabetic retinopathy; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg03759077 chr2:153575599 ARL6IP6 0.51 7.18 0.37 4.6e-12 Response to antipsychotic treatment; CRC cis rs9291683 0.530 rs35908990 chr4:9976105 G/A cg00071950 chr4:10020882 SLC2A9 0.64 11.88 0.55 2.61e-27 Bone mineral density; CRC cis rs12477438 0.871 rs13396584 chr2:99611768 G/T cg26064155 chr2:99771622 LIPT1;TSGA10 0.64 7.87 0.4 5.2e-14 Chronic sinus infection; CRC cis rs4561483 0.831 rs33648 chr16:11979622 G/A cg08843971 chr16:11963173 GSPT1 -0.62 -8.79 -0.44 8.65e-17 Testicular germ cell tumor; CRC cis rs2404602 0.716 rs2164101 chr15:76749117 A/G cg23625390 chr15:77176239 SCAPER 0.49 7.15 0.37 5.48e-12 Blood metabolite levels; CRC cis rs2929278 0.617 rs2955969 chr15:44114527 G/A cg02155558 chr15:43621948 ADAL;LCMT2 -0.43 -5.95 -0.31 6.96e-9 Schizophrenia; CRC cis rs6448317 0.954 rs13139649 chr4:24922007 C/A cg21108841 chr4:24914750 CCDC149 -0.46 -6.06 -0.32 3.72e-9 Heschl's gyrus morphology; CRC cis rs282587 0.569 rs9604415 chr13:113393615 G/T cg04656015 chr13:113407548 ATP11A 0.61 7.47 0.38 7.3e-13 Glycated hemoglobin levels; CRC cis rs6724607 0.905 rs10173771 chr2:191439248 T/C cg27211696 chr2:191398769 TMEM194B 0.41 6.1 0.32 2.99e-9 Pulse pressure; CRC cis rs908922 0.651 rs4845442 chr1:152485545 G/A cg09873164 chr1:152488093 CRCT1 0.36 6.07 0.32 3.6e-9 Hair morphology; CRC trans rs2303319 0.504 rs62189055 chr2:162625749 C/A cg03124313 chr19:36036028 GAPDHS;TMEM147 -0.67 -6.0 -0.31 5.21e-9 Cognitive function; CRC trans rs703108 0.731 rs7898954 chr10:22323646 A/G cg26468414 chr7:106810548 HBP1 -0.51 -6.04 -0.32 4.16e-9 Monocyte percentage of white cells; CRC cis rs7829975 0.714 rs4841040 chr8:8654527 T/C cg06636001 chr8:8085503 FLJ10661 0.61 9.61 0.47 1.98e-19 Mood instability; CRC cis rs798554 0.524 rs2283784 chr7:2855337 T/C cg13628971 chr7:2884303 GNA12 0.44 6.85 0.35 3.57e-11 Height; CRC cis rs7107174 1.000 rs1893448 chr11:77969180 G/A cg02023728 chr11:77925099 USP35 0.52 8.83 0.44 6.58e-17 Testicular germ cell tumor; CRC cis rs7739232 0.920 rs17216313 chr6:53530156 T/C cg15658676 chr6:53530538 KLHL31 -0.76 -5.9 -0.31 8.9e-9 Hip circumference adjusted for BMI; CRC cis rs9583531 0.689 rs9588247 chr13:111375571 G/T cg24331049 chr13:111365604 ING1 -0.57 -7.62 -0.39 2.77e-13 Coronary artery disease; CRC cis rs1707322 0.826 rs10890349 chr1:46249955 T/C cg06784218 chr1:46089804 CCDC17 0.6 10.93 0.52 6.45e-24 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs6860806 0.507 rs272891 chr5:131664394 G/T cg20512303 chr5:131592959 PDLIM4 0.4 6.83 0.35 4.21e-11 Breast cancer; CRC cis rs2976388 0.566 rs4736373 chr8:143792357 G/C cg20041105 chr8:143859282 LYNX1 -0.43 -6.93 -0.36 2.19e-11 Urinary tract infection frequency; CRC cis rs311392 0.526 rs311385 chr8:55101380 T/A cg06042504 chr8:55087323 NA -0.36 -5.72 -0.3 2.35e-8 Pelvic organ prolapse (moderate/severe); CRC cis rs6499255 0.951 rs7198242 chr16:69648495 C/T cg04110750 chr16:69646130 NFAT5 0.56 7.64 0.39 2.4e-13 IgE levels; CRC cis rs2859741 0.967 rs535876 chr1:37484052 C/G cg09363841 chr1:37513479 NA -0.62 -11.66 -0.54 1.55e-26 Forced expiratory volume in 1 second (environmental tobacco smoke interaction); CRC cis rs17818399 0.510 rs12105801 chr2:46799343 C/G cg26688816 chr2:46740690 ATP6V1E2 -0.49 -7.54 -0.38 4.73e-13 Height; CRC cis rs12145833 0.596 rs12123491 chr1:243297924 C/G cg02356786 chr1:243265016 LOC731275 0.79 6.08 0.32 3.39e-9 Obesity (early onset extreme); CRC cis rs8016982 0.674 rs759939 chr14:81663453 G/C cg01989461 chr14:81687754 GTF2A1 0.63 10.3 0.49 9.84e-22 Schizophrenia; CRC cis rs9311474 0.508 rs11720243 chr3:52618018 T/C cg18099408 chr3:52552593 STAB1 -0.48 -8.26 -0.41 3.69e-15 Electroencephalogram traits; CRC cis rs853679 0.542 rs9380063 chr6:28137853 A/G cg15845792 chr6:28175446 NA 1.04 13.89 0.61 7.67e-35 Depression; CRC cis rs9926296 0.712 rs2437957 chr16:89715648 G/A cg01097406 chr16:89675127 NA 0.53 9.66 0.47 1.39e-19 Vitiligo; CRC cis rs875971 0.545 rs801199 chr7:66025273 A/G cg03233332 chr7:66118400 NA 0.43 6.03 0.32 4.35e-9 Aortic root size; CRC cis rs7552404 1.000 rs7533888 chr1:76160449 A/C cg22875332 chr1:76189707 ACADM 0.68 9.25 0.45 2.82e-18 Blood metabolite levels;Acylcarnitine levels; CRC cis rs9322817 0.691 rs2499660 chr6:105285750 T/C cg02098413 chr6:105308735 HACE1 0.41 8.04 0.41 1.63e-14 Thyroid stimulating hormone; CRC cis rs7552404 0.961 rs17587071 chr1:76225083 A/C cg22875332 chr1:76189707 ACADM 0.7 9.56 0.47 2.9e-19 Blood metabolite levels;Acylcarnitine levels; CRC cis rs6460942 1.000 rs118083671 chr7:12466036 C/T cg20607287 chr7:12443886 VWDE -0.66 -6.93 -0.36 2.17e-11 Coronary artery disease; CRC cis rs614226 1.000 rs1167726 chr12:120967364 A/C cg27489772 chr12:121021490 NA -0.48 -6.51 -0.34 2.78e-10 Type 1 diabetes nephropathy; CRC cis rs68170813 0.559 rs10953536 chr7:107021691 G/A cg02696742 chr7:106810147 HBP1 -0.57 -5.81 -0.3 1.51e-8 Coronary artery disease; CRC cis rs17711722 0.565 rs73372653 chr7:65442795 A/T cg05627663 chr7:65219948 SNORA22;CCT6P1 0.64 9.9 0.48 2.07e-20 Calcium levels; CRC cis rs10504229 0.683 rs35889486 chr8:58117749 T/A cg24829409 chr8:58192753 C8orf71 -0.55 -8.03 -0.4 1.71e-14 Developmental language disorder (linguistic errors); CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg23104823 chr14:45553408 PRPF39 0.52 6.9 0.36 2.73e-11 Thyroid stimulating hormone; CRC cis rs929354 0.713 rs6946947 chr7:156948787 T/C cg05182265 chr7:156933206 UBE3C -0.76 -14.38 -0.62 1.04e-36 Body mass index; CRC cis rs3849570 0.961 rs10154945 chr3:81833766 A/C cg07356753 chr3:81810745 GBE1 -0.73 -11.01 -0.52 3.29e-24 Waist circumference;Body mass index; CRC cis rs6502050 0.835 rs34199331 chr17:80134487 C/T cg22110888 chr17:80059540 CCDC57 0.43 6.66 0.34 1.17e-10 Life satisfaction; CRC cis rs875971 1.000 rs4718357 chr7:65960878 A/G cg00343986 chr7:65444356 GUSB 0.44 6.47 0.34 3.56e-10 Aortic root size; CRC cis rs2120019 0.935 rs12591119 chr15:75355944 A/G cg09165964 chr15:75287851 SCAMP5 -0.85 -12.98 -0.58 2.24e-31 Blood trace element (Zn levels); CRC cis rs748404 0.578 rs2278856 chr15:43631356 G/A cg15269541 chr15:43626905 ADAL -0.36 -5.64 -0.3 3.76e-8 Lung cancer; CRC cis rs501120 0.657 rs115299170 chr10:44742925 T/C cg09554077 chr10:44749378 NA 0.83 10.78 0.51 2.11e-23 Coronary artery disease;Coronary heart disease; CRC cis rs3617 0.573 rs6795646 chr3:52922621 C/T cg11645453 chr3:52864694 ITIH4 -0.35 -6.7 -0.35 9.14e-11 Red blood cell count;Autism spectrum disorder or schizophrenia; CRC cis rs5769707 0.967 rs763126 chr22:49988574 G/T cg20744362 chr22:50050164 C22orf34 -0.28 -5.66 -0.3 3.28e-8 Monocyte count;Monocyte percentage of white cells; CRC cis rs7517126 1.000 rs35002268 chr1:196838511 G/A cg13682187 chr1:196946512 CFHR5 -0.36 -5.91 -0.31 8.52e-9 Blood protein levels; CRC cis rs10791097 0.629 rs11222361 chr11:130731424 T/G cg12179176 chr11:130786555 SNX19 0.67 10.78 0.51 2.04e-23 Autism spectrum disorder or schizophrenia;Schizophrenia; CRC cis rs12760731 0.565 rs12026482 chr1:178155861 G/A cg00404053 chr1:178313656 RASAL2 1.02 10.74 0.51 2.85e-23 Obesity-related traits; CRC cis rs6500602 0.627 rs3848372 chr16:4587875 C/A cg08645402 chr16:4508243 NA 0.55 8.59 0.43 3.5e-16 Schizophrenia; CRC cis rs10924970 0.625 rs2789366 chr1:235508270 G/A cg09010748 chr1:235293032 TOMM20 -0.44 -6.1 -0.32 2.91e-9 Asthma; CRC cis rs6502050 0.835 rs4789666 chr17:80162276 C/T cg22110888 chr17:80059540 CCDC57 0.42 6.63 0.34 1.37e-10 Life satisfaction; CRC cis rs7772486 0.566 rs735536 chr6:146036832 A/C cg13319975 chr6:146136371 FBXO30 0.44 6.64 0.34 1.3100000000000001e-10 Lobe attachment (rater-scored or self-reported); CRC cis rs9467711 0.591 rs9467621 chr6:25851338 G/A cg16898833 chr6:26189333 HIST1H4D 0.79 6.5 0.34 2.95e-10 Autism spectrum disorder or schizophrenia; CRC cis rs13161895 1.000 rs6873781 chr5:179436734 A/C cg02702477 chr5:179499311 RNF130 -0.56 -6.48 -0.34 3.35e-10 LDL cholesterol; CRC cis rs3796352 1.000 rs34943350 chr3:53012888 C/T cg27565382 chr3:53032988 SFMBT1 0.72 5.71 0.3 2.47e-8 Immune reponse to smallpox (secreted IL-2); CRC cis rs60871478 0.636 rs12534606 chr7:895928 A/G cg13798912 chr7:905769 UNC84A -0.63 -6.97 -0.36 1.74e-11 Cerebrospinal P-tau181p levels; CRC cis rs832540 0.898 rs702680 chr5:56220382 T/C cg18230493 chr5:56204884 C5orf35 -0.41 -6.06 -0.32 3.81e-9 Coronary artery disease; CRC cis rs2836950 0.520 rs8133928 chr21:40689963 G/A cg11644478 chr21:40555479 PSMG1 -0.44 -6.53 -0.34 2.56e-10 Menarche (age at onset); CRC cis rs6479527 0.806 rs1933669 chr9:96743654 C/T cg14459158 chr9:96720562 NA 0.39 7.05 0.36 1.04e-11 Esophageal adenocarcinoma; CRC cis rs11098499 0.954 rs28429722 chr4:120300093 G/A cg24375607 chr4:120327624 NA 0.51 7.86 0.4 5.5e-14 Corneal astigmatism; CRC cis rs28386778 0.897 rs6504177 chr17:61812655 C/T cg25654072 chr17:61904446 PSMC5;FTSJ3 0.68 10.66 0.51 5.55e-23 Prudent dietary pattern; CRC cis rs7508679 1.000 rs10401485 chr19:7222234 T/C cg00428638 chr19:7224713 INSR 0.94 18.93 0.72 1.41e-54 Hypothyroidism; CRC cis rs7618501 0.633 rs2883057 chr3:49998282 C/T cg24110177 chr3:50126178 RBM5 -0.46 -6.82 -0.35 4.46e-11 Intelligence (multi-trait analysis); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg12849291 chr2:97535965 SEMA4C 0.41 6.68 0.35 1e-10 Liver disease severity in Alagille syndrome; CRC cis rs2479724 0.905 rs2251274 chr6:41839438 T/G cg17623882 chr6:41773611 USP49 -0.58 -9.96 -0.48 1.37e-20 Menarche (age at onset); CRC cis rs11212617 1.000 rs637064 chr11:108140909 C/T cg01991180 chr11:108092276 ATM;NPAT 0.42 6.11 0.32 2.87e-9 Response to metformin in type 2 diabetes (glycemic); CRC cis rs60871478 1.000 rs12531530 chr7:827366 T/C cg13798912 chr7:905769 UNC84A 0.55 6.34 0.33 7.56e-10 Cerebrospinal P-tau181p levels; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg22522926 chr2:131851181 FAM168B 0.45 6.28 0.33 1.05e-9 Response to antipsychotic treatment; CRC cis rs853679 0.517 rs9380055 chr6:28081629 A/G cg02631126 chr6:28058918 ZSCAN12L1 0.29 5.87 0.31 1.05e-8 Depression; CRC cis rs7542091 0.704 rs1108628 chr1:210041150 A/G cg05527609 chr1:210001259 C1orf107 -0.43 -5.64 -0.3 3.64e-8 Monobrow; CRC cis rs17209837 0.607 rs4148820 chr7:87080482 T/C cg00919237 chr7:87102261 ABCB4 -0.52 -6.81 -0.35 4.72e-11 Gallbladder cancer; CRC cis rs765787 0.530 rs11636440 chr15:45535982 C/T cg24006582 chr15:45444508 DUOX1 -0.56 -8.6 -0.43 3.28e-16 Uric acid levels; CRC cis rs10927875 0.596 rs1806990 chr1:16129377 G/A cg21385522 chr1:16154831 NA -1.07 -17.43 -0.69 1.18e-48 Dilated cardiomyopathy; CRC cis rs10504073 0.647 rs11785310 chr8:50025035 G/A cg00325661 chr8:49890786 NA 0.52 9.29 0.46 2.13e-18 Blood metabolite ratios; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg11237883 chr7:75677249 STYXL1;MDH2 0.44 6.14 0.32 2.43e-9 Response to antipsychotic treatment; CRC cis rs13064411 0.696 rs7624994 chr3:113228009 T/C cg10517650 chr3:113235015 CCDC52 -0.41 -7.29 -0.37 2.4e-12 Response to simvastatin treatment (PCSK9 protein level change); CRC cis rs490234 0.702 rs1891035 chr9:128258684 T/C cg14078157 chr9:128172775 NA -0.39 -6.33 -0.33 7.91e-10 Mean arterial pressure; CRC trans rs6550704 0.687 rs9865314 chr3:22634337 A/G cg18585273 chr17:66197086 NA -0.44 -6.58 -0.34 1.81e-10 Daytime sleep phenotypes; CRC cis rs9322193 0.884 rs62439837 chr6:149991516 G/T cg00933542 chr6:150070202 PCMT1 0.3 5.95 0.31 6.9e-9 Lung cancer; CRC cis rs11031096 0.542 rs1452048 chr11:3965428 G/T cg18678763 chr11:4115507 RRM1 -0.4 -6.77 -0.35 5.95e-11 Mean corpuscular volume;Mean corpuscular hemoglobin; CRC cis rs4605213 0.605 rs41524846 chr17:49252238 A/G cg00965052 chr17:49230932 NME1;NME1-NME2 0.44 6.39 0.33 5.61e-10 Height; CRC cis rs2976388 0.566 rs6998746 chr8:143802456 A/C cg10596483 chr8:143751796 JRK 0.42 5.86 0.31 1.14e-8 Urinary tract infection frequency; CRC cis rs35362007 0.530 rs10484053 chr14:96011645 C/T cg13511115 chr14:96000878 GLRX5;SNHG10;SCARNA13 0.64 5.86 0.31 1.12e-8 Mean corpuscular volume;Mean corpuscular hemoglobin; CRC cis rs6772849 0.930 rs55987729 chr3:128340110 T/C cg08795948 chr3:128337044 NA 0.34 5.91 0.31 8.59e-9 Monocyte percentage of white cells;Monocyte count; CRC cis rs2795502 0.882 rs2744091 chr10:43339441 A/G cg27426351 chr10:43362370 NA -0.58 -6.99 -0.36 1.57e-11 Blood protein levels; CRC cis rs853679 0.882 rs9468287 chr6:28079741 G/T cg06470822 chr6:28175283 NA 0.81 6.46 0.34 3.8e-10 Depression; CRC cis rs832540 0.931 rs2662040 chr5:56246610 A/G cg24531977 chr5:56204891 C5orf35 0.51 7.86 0.4 5.48e-14 Coronary artery disease; CRC cis rs1267303 0.675 rs7519040 chr1:46986641 A/G cg08533674 chr1:46993347 NA -0.63 -8.13 -0.41 8.62e-15 Monobrow; CRC cis rs6570726 0.791 rs9403734 chr6:145931459 C/G cg05347473 chr6:146136440 FBXO30 0.38 5.66 0.3 3.3e-8 Lobe attachment (rater-scored or self-reported); CRC cis rs10493773 1.000 rs7523292 chr1:86134992 A/G cg17807903 chr1:86174739 ZNHIT6 -0.49 -9.66 -0.47 1.31e-19 Urate levels in overweight individuals; CRC cis rs62458065 0.513 rs10265319 chr7:32571564 A/C cg20159608 chr7:32802032 NA -0.63 -8.09 -0.41 1.13e-14 Metabolite levels (HVA/MHPG ratio); CRC cis rs8067545 0.611 rs2703771 chr17:20130154 C/G cg13482628 chr17:19912719 NA -0.47 -7.38 -0.38 1.31e-12 Schizophrenia; CRC cis rs2455601 0.744 rs2163626 chr11:8983547 A/G cg09997546 chr11:8931473 C11orf17;ST5 -0.47 -6.52 -0.34 2.58e-10 Schizophrenia; CRC cis rs9322193 0.923 rs2297930 chr6:150039496 T/C cg13206674 chr6:150067644 NUP43 0.65 9.76 0.47 6.08e-20 Lung cancer; CRC cis rs7552404 0.924 rs2275378 chr1:76198436 T/C cg22875332 chr1:76189707 ACADM 0.8 12.0 0.55 9.4e-28 Blood metabolite levels;Acylcarnitine levels; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg21219203 chr4:103748293 UBE2D3 0.5 7.16 0.37 5.14e-12 Response to antipsychotic treatment; CRC cis rs2839186 0.771 rs2839155 chr21:47639992 A/G cg13126279 chr21:47581558 C21orf56 -0.52 -8.48 -0.42 7.55e-16 Testicular germ cell tumor; CRC cis rs3849570 0.925 rs13091492 chr3:81891476 A/G cg07356753 chr3:81810745 GBE1 -0.65 -9.46 -0.46 6.15e-19 Waist circumference;Body mass index; CRC cis rs10256972 0.621 rs2363285 chr7:1091644 C/T cg04025307 chr7:1156635 C7orf50 0.39 6.13 0.32 2.47e-9 Longevity;Endometriosis; CRC cis rs6921919 0.638 rs1416920 chr6:28302784 A/G cg06470822 chr6:28175283 NA 0.48 6.43 0.33 4.59e-10 Autism spectrum disorder or schizophrenia; CRC cis rs3736594 0.513 rs1881396 chr2:27844601 G/T cg27432699 chr2:27873401 GPN1 -0.65 -8.38 -0.42 1.54e-15 Fasting blood glucose;Fasting blood glucose (BMI interaction); CRC cis rs9393692 0.905 rs6931391 chr6:26279235 G/C cg13736514 chr6:26305472 NA -0.62 -11.75 -0.54 7.66e-27 Educational attainment; CRC trans rs6951245 0.580 rs78894484 chr7:1138721 T/G cg13565492 chr6:43139072 SRF -0.84 -10.61 -0.5 8.06e-23 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs36229146 1 rs36229146 chr7:22784486 TTATATATAAATATATATATATATATA/T cg26061582 chr7:22766209 IL6 0.53 7.9 0.4 4.11e-14 Eosinophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Sum eosinophil basophil counts;Eosinophil percentage of white cells; CRC cis rs3743266 0.634 rs7165874 chr15:60784609 A/T cg21667061 chr15:60772094 NARG2 0.28 5.69 0.3 2.76e-8 Menarche (age at onset); CRC cis rs58688157 0.705 rs12419720 chr11:598205 C/G cg16486109 chr11:613632 IRF7 0.73 12.46 0.57 1.94e-29 Systemic lupus erythematosus; CRC cis rs7677751 0.806 rs60806423 chr4:55086816 C/T cg17187183 chr4:55093834 PDGFRA 0.52 7.57 0.39 3.81e-13 Corneal astigmatism; CRC cis rs28386778 0.897 rs6504177 chr17:61812655 C/T cg11494091 chr17:61959527 GH2 0.54 9.08 0.45 1.04e-17 Prudent dietary pattern; CRC cis rs6500602 0.727 rs4786515 chr16:4578133 T/A cg14951292 chr16:4525986 HMOX2;NMRAL1 0.58 8.79 0.44 8.46e-17 Schizophrenia; CRC cis rs12681287 0.547 rs4961197 chr8:87512436 T/C cg27223183 chr8:87520930 FAM82B -0.52 -7.41 -0.38 1.05e-12 Caudate activity during reward; CRC cis rs9549367 0.826 rs2302755 chr13:113898418 C/T cg18105134 chr13:113819100 PROZ -0.68 -9.95 -0.48 1.44e-20 Platelet distribution width; CRC cis rs9583531 0.574 rs7319459 chr13:111352408 T/C cg24331049 chr13:111365604 ING1 -0.61 -8.42 -0.42 1.21e-15 Coronary artery disease; CRC cis rs4862750 0.914 rs11943333 chr4:187872455 A/G cg03452623 chr4:187889614 NA -0.85 -17.78 -0.7 5.05e-50 Lobe attachment (rater-scored or self-reported); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg23367851 chr7:25165401 CYCS 0.44 6.18 0.32 1.92e-9 Response to antipsychotic treatment; CRC cis rs4242434 0.927 rs720746 chr8:22471399 T/C cg03733263 chr8:22462867 KIAA1967 1.03 19.2 0.73 1.21e-55 Exploratory eye movement dysfunction in schizophrenia (cognitive search score); CRC cis rs514406 0.929 rs12145105 chr1:53340564 T/C cg27535305 chr1:53392650 SCP2 -0.36 -6.47 -0.34 3.56e-10 Monocyte count; CRC cis rs10986311 0.775 rs3758207 chr9:127132020 C/T cg14243010 chr9:127117328 LOC100129034;PSMB7 -0.39 -6.0 -0.31 5.1e-9 Vitiligo; CRC cis rs2576037 0.583 rs11659693 chr18:44458733 C/T cg23996704 chr18:44553084 KATNAL2 -0.34 -7.02 -0.36 1.25e-11 Personality dimensions; CRC trans rs36069016 1 rs36069016 chr8:25058491 C/T cg23013931 chr22:41214857 SLC25A17 -0.48 -5.97 -0.31 6.05e-9 Coronary artery disease; CRC cis rs9522267 0.535 rs7339347 chr13:112237920 C/T cg10483660 chr13:112241077 NA -0.48 -9.22 -0.45 3.7e-18 Hepatitis; CRC cis rs17162190 0.698 rs4659443 chr1:26823631 C/T cg17456097 chr1:26900765 RPS6KA1 0.43 6.16 0.32 2.17e-9 Mean corpuscular volume; CRC cis rs853679 0.517 rs9468292 chr6:28095355 G/A cg18032046 chr6:28092343 ZSCAN16 -0.52 -6.08 -0.32 3.3e-9 Depression; CRC cis rs28386778 0.863 rs2251164 chr17:61884120 G/A cg11494091 chr17:61959527 GH2 0.59 10.03 0.48 7.61e-21 Prudent dietary pattern; CRC cis rs10911232 0.524 rs10737238 chr1:183025303 A/G ch.1.3577855R chr1:183094577 LAMC1 0.84 14.64 0.63 9.82e-38 Hypertriglyceridemia; CRC cis rs7973719 0.833 rs7962563 chr12:7353514 G/A cg07052231 chr12:7363540 PEX5 0.53 8.48 0.42 7.9e-16 IgG glycosylation; CRC cis rs7044106 0.762 rs1158554 chr9:123400898 G/A cg14255062 chr9:123606675 PSMD5;LOC253039 0.45 6.9 0.36 2.64e-11 Hip circumference adjusted for BMI; CRC cis rs35264875 1.000 rs1542334 chr11:68850773 G/C cg23740940 chr11:68924746 NA 0.44 5.75 0.3 2.04e-8 Blond vs. brown hair color; CRC cis rs4713118 0.539 rs200988 chr6:27819353 A/C cg26587870 chr6:27730563 NA -0.43 -6.64 -0.34 1.3e-10 Parkinson's disease; CRC cis rs61656020 1 rs61656020 chr16:1882221 C/G cg03013636 chr16:1946785 NA 0.54 6.78 0.35 5.45e-11 Ankle injury; CRC cis rs8177253 0.665 rs9869535 chr3:133451581 G/A cg16262614 chr3:133464971 TF 0.4 7.09 0.36 8.42e-12 Iron status biomarkers; CRC cis rs11025559 0.716 rs1596376 chr11:20454229 T/C cg19653624 chr11:20408972 PRMT3 -0.64 -7.9 -0.4 4.14e-14 Pursuit maintenance gain; CRC cis rs4423214 0.959 rs11606611 chr11:71164046 C/G cg05163923 chr11:71159392 DHCR7 0.67 9.53 0.46 3.69e-19 Vitamin D levels; CRC cis rs12188164 0.965 rs11739543 chr5:443676 G/A cg26850624 chr5:429559 AHRR -0.81 -13.6 -0.6 9.63e-34 Cystic fibrosis severity; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg04738309 chr5:111093624 C5orf13 0.47 6.67 0.35 1.12e-10 Response to antipsychotic treatment; CRC cis rs4665809 0.590 rs5001914 chr2:26415429 A/G cg26119090 chr2:26468346 HADHA;HADHB -1.05 -15.22 -0.64 5.61e-40 Gut microbiome composition (summer); CRC cis rs3806843 0.576 rs246062 chr5:140324580 T/A cg19875535 chr5:140030758 IK 0.39 6.02 0.31 4.67e-9 Depressive symptoms (multi-trait analysis); CRC cis rs9462027 0.628 rs6919654 chr6:34810739 A/G cg07306190 chr6:34760872 UHRF1BP1 -0.34 -6.02 -0.32 4.63e-9 Systemic lupus erythematosus; CRC cis rs7072216 0.687 rs11189586 chr10:100154096 A/G cg26618903 chr10:100175079 PYROXD2 -0.35 -5.64 -0.3 3.64e-8 Metabolite levels; CRC cis rs896854 0.517 rs10112447 chr8:95955701 C/T cg16049864 chr8:95962084 TP53INP1 -0.46 -7.34 -0.38 1.7e-12 Type 2 diabetes; CRC cis rs7605827 0.930 rs7571679 chr2:15596603 C/T cg19274914 chr2:15703543 NA 0.39 5.92 0.31 8.31e-9 Educational attainment (years of education); CRC cis rs4975709 0.589 rs4975744 chr5:1860049 A/G cg12288994 chr5:1860383 NA 0.41 7.24 0.37 3.13e-12 Cardiovascular disease risk factors; CRC trans rs877282 0.853 rs7069720 chr10:754487 A/G cg22713356 chr15:30763199 NA 1.19 13.88 0.61 8.17e-35 Uric acid levels; CRC cis rs4750440 0.702 rs33945078 chr10:14022425 G/A cg00551146 chr10:14014579 FRMD4A 0.37 6.02 0.31 4.71e-9 Adiponectin levels; CRC cis rs12950390 0.853 rs17773010 chr17:45858297 C/T cg24803719 chr17:45855879 NA -0.32 -7.03 -0.36 1.16e-11 IgG glycosylation; CRC cis rs10992471 0.756 rs10115222 chr9:95128149 C/T cg13798575 chr9:95087839 CENPP;NOL8 0.48 6.91 0.36 2.55e-11 Visceral adipose tissue/subcutaneous adipose tissue ratio; CRC cis rs9916302 0.904 rs11078898 chr17:37536480 A/G cg00129232 chr17:37814104 STARD3 0.53 7.92 0.4 3.73e-14 Glomerular filtration rate (creatinine); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg07307803 chr16:69600533 NFAT5;MIR1538 0.4 6.07 0.32 3.61e-9 Intelligence (multi-trait analysis); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg25062812 chr14:25519484 STXBP6 0.39 6.04 0.32 4.12e-9 Liver disease severity in Alagille syndrome; CRC trans rs2413583 0.591 rs17000979 chr22:39700758 C/T cg09612413 chr10:12085555 UPF2 -0.54 -6.25 -0.33 1.28e-9 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; CRC cis rs9443645 0.808 rs9361484 chr6:79758218 C/A cg09184832 chr6:79620586 NA -0.5 -9.16 -0.45 5.67e-18 Intelligence (multi-trait analysis); CRC cis rs3087591 0.959 rs2051505 chr17:29699859 C/G cg24425628 chr17:29625626 OMG;NF1 -0.85 -16.47 -0.67 7.23e-45 Hip circumference; CRC cis rs11212617 0.967 rs227054 chr11:108257943 A/G cg01991180 chr11:108092276 ATM;NPAT 0.44 6.37 0.33 6.42e-10 Response to metformin in type 2 diabetes (glycemic); CRC cis rs889312 0.500 rs252905 chr5:56118875 C/T cg18230493 chr5:56204884 C5orf35 -0.42 -6.4 -0.33 5.34e-10 Breast cancer;Breast cancer (early onset); CRC cis rs9467711 0.591 rs35528636 chr6:25995701 A/C cg08501292 chr6:25962987 TRIM38 0.84 7.76 0.39 1.1e-13 Autism spectrum disorder or schizophrenia; CRC cis rs2952156 0.883 rs2517960 chr17:37846521 T/C cg07936489 chr17:37558343 FBXL20 -0.46 -6.62 -0.34 1.43e-10 Asthma; CRC cis rs709400 0.633 rs7160208 chr14:103965528 G/A cg12935359 chr14:103987150 CKB -0.51 -8.31 -0.42 2.52e-15 Body mass index; CRC cis rs6502050 0.835 rs8078795 chr17:80126320 C/T cg11859384 chr17:80120422 CCDC57 -0.36 -5.6 -0.3 4.51e-8 Life satisfaction; CRC cis rs6952808 0.792 rs2056480 chr7:1954301 A/G cg04267008 chr7:1944627 MAD1L1 0.84 13.02 0.58 1.53e-31 Bipolar disorder and schizophrenia; CRC cis rs875971 0.545 rs12673308 chr7:65631361 C/A cg11764359 chr7:65958608 NA 0.47 5.9 0.31 9.21e-9 Aortic root size; CRC cis rs477895 0.713 rs11600867 chr11:63972052 T/A cg23719950 chr11:63933701 MACROD1 -0.67 -8.36 -0.42 1.75e-15 Mean platelet volume; CRC cis rs4654899 0.796 rs77366434 chr1:21520069 C/T cg02927042 chr1:21476669 EIF4G3 -0.51 -8.13 -0.41 8.73e-15 Superior frontal gyrus grey matter volume; CRC cis rs597539 0.652 rs513615 chr11:68705504 G/T cg06112835 chr11:68658793 MRPL21 0.42 6.65 0.34 1.21e-10 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs6502050 0.835 rs28640920 chr17:80105151 A/T cg11859384 chr17:80120422 CCDC57 -0.37 -5.85 -0.31 1.16e-8 Life satisfaction; CRC cis rs35110281 0.626 rs162367 chr21:44934857 A/G cg04455712 chr21:45112962 RRP1B 0.38 7.12 0.37 6.8e-12 Mean corpuscular volume; CRC cis rs1552244 0.706 rs279545 chr3:9972493 A/G cg02579736 chr3:10068473 FANCD2;CIDECP 0.67 9.05 0.45 1.24e-17 Alzheimer's disease; CRC cis rs5769765 0.862 rs138857 chr22:50199589 C/T cg04121214 chr22:50244548 NA 0.4 5.71 0.3 2.47e-8 Schizophrenia; CRC cis rs8180040 0.966 rs3736177 chr3:47451411 C/T cg27129171 chr3:47204927 SETD2 -0.62 -9.45 -0.46 6.79e-19 Colorectal cancer; CRC cis rs644799 0.509 rs580181 chr11:95643040 G/C cg25622487 chr11:95524042 FAM76B;CEP57 0.51 7.42 0.38 9.79e-13 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs7703744 0.681 rs73239280 chr5:118695579 G/A cg23917399 chr5:118691751 TNFAIP8 0.43 5.93 0.31 7.84e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs12348691 0.503 rs7848950 chr9:100612774 T/C cg13688889 chr9:100608707 NA -0.47 -6.03 -0.32 4.45e-9 Alopecia areata; CRC cis rs9916302 0.706 rs7208487 chr17:37543449 T/G cg07936489 chr17:37558343 FBXL20 0.92 11.73 0.54 9.09e-27 Glomerular filtration rate (creatinine); CRC cis rs6502050 0.835 rs8080423 chr17:80102279 A/G cg02741985 chr17:80059408 CCDC57 0.43 7.15 0.37 5.66e-12 Life satisfaction; CRC cis rs11190604 1.000 rs7079756 chr10:102302105 G/A cg07080220 chr10:102295463 HIF1AN 0.49 6.32 0.33 8.51e-10 Palmitoleic acid (16:1n-7) levels; CRC cis rs9296736 0.885 rs9349693 chr6:53939724 A/G cg04374786 chr6:53939321 C6orf142 0.44 7.1 0.36 7.62e-12 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs9303401 0.659 rs11495824 chr17:56918882 C/A cg02118635 chr17:56770003 RAD51C;TEX14 0.78 9.94 0.48 1.59e-20 Cognitive test performance; CRC cis rs1862618 0.715 rs6866779 chr5:56090000 G/A cg18230493 chr5:56204884 C5orf35 -0.76 -9.71 -0.47 8.96e-20 Initial pursuit acceleration; CRC cis rs344364 0.511 rs1742468 chr16:1950243 C/G cg00046913 chr16:1877150 HAGH;FAHD1 -0.58 -6.06 -0.32 3.66e-9 Glomerular filtration rate in chronic kidney disease; CRC cis rs6504622 0.537 rs197918 chr17:45003080 A/G cg16759221 chr17:45003025 GOSR2 -0.72 -11.41 -0.53 1.27e-25 Orofacial clefts; CRC trans rs2018683 0.677 rs2057956 chr7:28973460 G/A cg19402173 chr7:128379420 CALU -0.43 -6.23 -0.32 1.39e-9 Response to irinotecan and platinum-based chemotherapy in non-small-cell lung cancer; CRC trans rs2797160 1.000 rs2747723 chr6:126010790 C/T cg05039488 chr6:79577232 IRAK1BP1 0.5 7.51 0.38 5.8e-13 Endometrial cancer; CRC cis rs1153858 1.000 rs11070453 chr15:45645154 C/G cg14582100 chr15:45693742 SPATA5L1 0.29 5.96 0.31 6.5e-9 Homoarginine levels; CRC cis rs2243480 1.000 rs422164 chr7:65586605 C/G cg25985355 chr7:65971099 NA -0.49 -5.77 -0.3 1.85e-8 Diabetic kidney disease; CRC cis rs9648716 0.766 rs801157 chr7:140780908 T/G cg10747023 chr7:140774559 NA -0.46 -6.09 -0.32 3.1e-9 Type 2 diabetes; CRC cis rs2735413 0.918 rs4888733 chr16:78080523 C/T cg04733911 chr16:78082701 NA -0.44 -7.37 -0.38 1.38e-12 Systolic blood pressure (alcohol consumption interaction); CRC cis rs9467711 0.606 rs9366656 chr6:26434630 T/C cg08501292 chr6:25962987 TRIM38 0.83 6.43 0.33 4.44e-10 Autism spectrum disorder or schizophrenia; CRC cis rs951366 0.589 rs823099 chr1:205669322 C/A cg23034840 chr1:205782522 SLC41A1 0.49 6.41 0.33 5.08e-10 Menarche (age at onset); CRC cis rs2836974 0.932 rs2836953 chr21:40617483 G/A cg06238570 chr21:40685208 BRWD1 0.72 10.17 0.49 2.58e-21 Cognitive function; CRC cis rs9584850 0.834 rs12869627 chr13:99120452 G/A cg07423050 chr13:99094983 FARP1 0.45 6.36 0.33 6.9e-10 Neuroticism; CRC cis rs45509595 0.841 rs9368531 chr6:27781872 G/C cg03623178 chr6:28175578 NA 0.78 6.64 0.34 1.27e-10 Breast cancer; CRC cis rs6541297 1.000 rs1997947 chr1:230283764 A/G cg05784532 chr1:230284198 GALNT2 -0.4 -5.61 -0.3 4.29e-8 Coronary artery disease; CRC cis rs2303759 0.918 rs10405465 chr19:49869298 C/T cg22590775 chr19:49891494 CCDC155 0.58 8.54 0.43 5.12e-16 Multiple sclerosis; CRC cis rs28386778 0.701 rs2727337 chr17:61991966 G/A cg22520471 chr17:61851767 DDX42;CCDC47 -0.64 -9.63 -0.47 1.65e-19 Prudent dietary pattern; CRC cis rs7408868 1.000 rs10410514 chr19:15277610 C/T cg14696996 chr19:15285081 NOTCH3 0.96 9.0 0.44 1.82e-17 Pulse pressure; CRC cis rs9914988 1.000 rs6803 chr17:27187789 C/T cg16670446 chr17:27188758 MIR451;MIR144 -0.61 -10.46 -0.5 2.74e-22 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs370915 0.542 rs1425953 chr4:187833652 A/C cg19519643 chr4:187840862 NA -0.63 -10.9 -0.51 8.18e-24 Gout; CRC cis rs2811415 0.597 rs1007232 chr3:127801896 C/A cg13719885 chr3:127795394 NA -0.39 -5.85 -0.31 1.17e-8 Lung function (FEV1/FVC); CRC trans rs61931739 0.500 rs11053269 chr12:34545307 A/G cg13010199 chr12:38710504 ALG10B 0.45 6.52 0.34 2.65e-10 Morning vs. evening chronotype; CRC cis rs9911578 0.867 rs4793941 chr17:56472366 G/A cg05425664 chr17:57184151 TRIM37 0.46 7.06 0.36 9.89e-12 Intelligence (multi-trait analysis); CRC cis rs10927875 0.518 rs1763597 chr1:16343297 C/T cg24140574 chr1:16342155 HSPB7 0.47 6.74 0.35 7.16e-11 Dilated cardiomyopathy; CRC cis rs832540 0.898 rs702680 chr5:56220382 T/C cg24531977 chr5:56204891 C5orf35 -0.5 -7.59 -0.39 3.38e-13 Coronary artery disease; CRC cis rs7020830 0.898 rs2790063 chr9:37287405 G/A cg14294708 chr9:37120828 ZCCHC7 1.03 20.07 0.74 4.35e-59 Schizophrenia; CRC cis rs2717559 0.542 rs10956986 chr8:143886601 C/T cg05569086 chr8:143859399 LYNX1 -0.64 -11.51 -0.54 5.45e-26 Urinary tract infection frequency; CRC cis rs117623576 0.941 rs72784865 chr10:32443875 A/C cg03047570 chr10:32398778 NA -0.66 -6.28 -0.33 1.04e-9 Anti-saccade response; CRC cis rs68170813 0.521 rs61673847 chr7:106892431 A/G cg02696742 chr7:106810147 HBP1 -0.6 -6.5 -0.34 2.97e-10 Coronary artery disease; CRC cis rs6912958 0.754 rs2268994 chr6:88185386 A/T cg12350822 chr6:88032061 C6orf162;GJB7 -0.34 -6.39 -0.33 5.82e-10 Monocyte percentage of white cells; CRC cis rs853679 0.517 rs9393893 chr6:28109262 T/C cg03623178 chr6:28175578 NA 0.98 12.66 0.57 3.31e-30 Depression; CRC cis rs7615952 0.641 rs66520539 chr3:125780374 G/A cg15145296 chr3:125709740 NA -0.57 -6.75 -0.35 6.67e-11 Blood pressure (smoking interaction); CRC cis rs10504229 0.683 rs2318143 chr8:58114660 C/T cg02725872 chr8:58115012 NA -0.65 -11.61 -0.54 2.34e-26 Developmental language disorder (linguistic errors); CRC cis rs72781680 1.000 rs72781658 chr2:24220141 A/G cg08917208 chr2:24149416 ATAD2B 1.01 9.72 0.47 8.58e-20 Lymphocyte counts; CRC cis rs17666538 0.539 rs1703925 chr8:608279 A/G cg07234876 chr8:600039 NA 0.86 7.75 0.39 1.17e-13 IgG glycosylation; CRC cis rs3540 0.960 rs1505936 chr15:91010776 T/C cg04176472 chr15:90893244 GABARAPL3 0.34 5.85 0.31 1.2e-8 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; CRC cis rs55794721 0.543 rs1293260 chr1:25709104 C/G cg27572855 chr1:25598939 RHD 0.37 6.68 0.35 1.05e-10 Plateletcrit;Mean corpuscular volume; CRC cis rs6076065 0.748 rs2180139 chr20:23405281 G/A cg11657817 chr20:23433608 CST11 0.5 8.19 0.41 5.82e-15 Facial morphology (factor 15, philtrum width); CRC cis rs17253792 0.915 rs28537145 chr14:56179119 G/A cg01858014 chr14:56050164 KTN1 -0.79 -6.09 -0.32 3.09e-9 Putamen volume; CRC cis rs4665809 0.941 rs1434079 chr2:26284670 C/G cg27170947 chr2:26402098 FAM59B -0.45 -5.94 -0.31 7.45e-9 Gut microbiome composition (summer); CRC cis rs4713118 0.662 rs149948 chr6:27974817 C/G cg12172441 chr6:28176163 NA 0.55 7.6 0.39 3.15e-13 Parkinson's disease; CRC cis rs2204008 0.627 rs11176531 chr12:38152166 T/G cg26384229 chr12:38710491 ALG10B 0.76 9.95 0.48 1.47e-20 Bladder cancer; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg11455018 chr16:30709778 SRCAP 0.46 5.97 0.31 6.21e-9 Thyroid stimulating hormone; CRC cis rs2952156 0.920 rs1565920 chr17:37831613 G/A cg00129232 chr17:37814104 STARD3 -0.7 -12.3 -0.56 7.27e-29 Asthma; CRC trans rs7267979 0.866 rs6138609 chr20:25570985 T/A cg17903999 chr18:56338584 MALT1 -0.42 -6.99 -0.36 1.57e-11 Liver enzyme levels (alkaline phosphatase); CRC cis rs8060686 0.698 rs8044558 chr16:68210165 T/C cg08314208 chr16:67682810 RLTPR -0.48 -5.79 -0.3 1.64e-8 HDL cholesterol;Metabolic syndrome; CRC cis rs10927875 0.632 rs4661666 chr1:16162471 C/A cg21385522 chr1:16154831 NA -1.11 -19.54 -0.73 5.48e-57 Dilated cardiomyopathy; CRC cis rs4731207 0.564 rs6466972 chr7:124596249 T/G cg23710748 chr7:124431027 NA -0.38 -6.08 -0.32 3.35e-9 Cutaneous malignant melanoma; CRC cis rs9354308 0.933 rs2802063 chr6:66564148 T/C cg07460842 chr6:66804631 NA 0.47 5.9 0.31 9.09e-9 Metabolite levels; CRC trans rs62295889 0.602 rs73096562 chr4:12542593 C/A cg03490839 chr16:73082051 ZFHX3 0.57 6.0 0.31 5.21e-9 Obesity-related traits; CRC cis rs1062746 0.520 rs67174101 chr16:87328817 G/A cg02258303 chr16:87377426 FBXO31 -0.5 -7.34 -0.38 1.67e-12 Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 2 peripheral neuropathy); CRC cis rs873946 0.648 rs3750578 chr10:134563366 A/G cg26818010 chr10:134567672 INPP5A -0.69 -8.92 -0.44 3.24e-17 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CRC cis rs7074356 0.688 rs34894697 chr10:82169888 T/C cg05935833 chr10:81318306 SFTPA2 -0.45 -6.54 -0.34 2.32e-10 Borderline personality disorder; CRC cis rs7493 1.000 rs6961773 chr7:95037718 T/G cg19678392 chr7:94953810 PON1 -0.59 -7.46 -0.38 7.92e-13 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs1816752 0.870 rs2033954 chr13:25010567 C/T cg02811702 chr13:24901961 NA 0.47 6.59 0.34 1.7e-10 Obesity-related traits; CRC cis rs6496667 0.779 rs2238320 chr15:90972441 C/T cg04176472 chr15:90893244 GABARAPL3 0.6 8.52 0.43 5.97e-16 Rheumatoid arthritis; CRC cis rs9837602 1.000 rs1021103 chr3:99603230 G/A cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G 0.47 5.68 0.3 3.03e-8 Breast cancer; CRC cis rs35306767 0.903 rs7914758 chr10:891702 T/C cg26597838 chr10:835615 NA 1.26 14.66 0.63 8.53e-38 Eosinophil percentage of granulocytes; CRC cis rs1862618 0.853 rs2548664 chr5:56133555 G/A cg20203395 chr5:56204925 C5orf35 -0.71 -8.56 -0.43 4.27e-16 Initial pursuit acceleration; CRC cis rs1005277 0.540 rs1814077 chr10:37992018 G/C cg25517755 chr10:38738941 LOC399744 -0.43 -6.21 -0.32 1.59e-9 Extrinsic epigenetic age acceleration; CRC cis rs10484885 0.878 rs72921955 chr6:90588789 C/G cg13799429 chr6:90582589 CASP8AP2 -0.72 -7.59 -0.39 3.3e-13 QRS interval (sulfonylurea treatment interaction); CRC trans rs10982213 0.830 rs2274163 chr9:117188714 C/T cg08962709 chr4:95128673 SMARCAD1 -0.43 -6.34 -0.33 7.54e-10 Interleukin-6 levels; CRC cis rs853679 0.723 rs1736904 chr6:28219270 G/A cg06470822 chr6:28175283 NA 0.75 8.79 0.44 8.2e-17 Depression; CRC cis rs12620999 0.941 rs10929213 chr2:238020637 A/G cg23555395 chr2:238036564 NA -0.62 -9.6 -0.47 2.19e-19 Systemic lupus erythematosus; CRC cis rs4713118 0.662 rs13218430 chr6:28029837 T/C cg12172441 chr6:28176163 NA 0.55 6.94 0.36 2.03e-11 Parkinson's disease; CRC trans rs7613875 0.580 rs2624819 chr3:50010571 G/T cg21665057 chr3:196295764 WDR53;FBXO45 0.47 7.07 0.36 9.5e-12 Body mass index; CRC cis rs9660180 0.868 rs12567685 chr1:1806647 T/C cg03396347 chr1:1875803 NA -0.64 -10.02 -0.48 8.45e-21 Body mass index; CRC cis rs2072499 0.750 rs2241109 chr1:156173082 C/T cg25208724 chr1:156163844 SLC25A44 1.02 16.64 0.68 1.47e-45 Testicular germ cell tumor; CRC cis rs3091242 0.900 rs669063 chr1:25721154 A/G cg27572855 chr1:25598939 RHD 0.36 6.57 0.34 1.93e-10 Erythrocyte sedimentation rate; CRC cis rs172166 0.694 rs536704 chr6:28092603 T/G cg25164649 chr6:28176230 NA 0.62 8.94 0.44 2.82e-17 Cardiac Troponin-T levels; CRC cis rs7666738 0.830 rs17548431 chr4:98923768 C/G cg17366294 chr4:99064904 C4orf37 0.43 7.32 0.37 1.95e-12 Colonoscopy-negative controls vs population controls; CRC trans rs61931739 0.500 rs34997501 chr12:34549828 C/G cg26384229 chr12:38710491 ALG10B 0.67 8.78 0.44 9.34e-17 Morning vs. evening chronotype; CRC cis rs2502731 0.539 rs3003609 chr9:130984755 A/G cg09976142 chr9:130955436 CIZ1 -0.42 -7.16 -0.37 5.4e-12 Attention deficit hyperactivity disorder; CRC trans rs61931739 0.500 rs11053177 chr12:34412829 G/A cg13010199 chr12:38710504 ALG10B 0.45 6.46 0.34 3.76e-10 Morning vs. evening chronotype; CRC cis rs10242455 0.702 rs57832867 chr7:98966396 C/T cg18809830 chr7:99032528 PTCD1 -1.01 -7.57 -0.39 3.67e-13 Blood metabolite levels; CRC trans rs11148252 1.000 rs11148252 chr13:53009048 C/T cg18335740 chr13:41363409 SLC25A15 0.52 8.25 0.41 3.96e-15 Lewy body disease; CRC cis rs7605827 0.576 rs35785577 chr2:15659611 A/G cg19274914 chr2:15703543 NA 0.39 5.87 0.31 1.06e-8 Educational attainment (years of education); CRC cis rs4478858 0.735 rs10798842 chr1:31778648 A/G cg07478791 chr1:31886160 SERINC2 -0.41 -5.74 -0.3 2.21e-8 Alcohol dependence; CRC cis rs10504229 0.683 rs10504224 chr8:58143735 A/G cg24829409 chr8:58192753 C8orf71 -0.63 -7.97 -0.4 2.64e-14 Developmental language disorder (linguistic errors); CRC cis rs8067545 0.586 rs3850779 chr17:20171872 C/T cg13482628 chr17:19912719 NA -0.48 -7.62 -0.39 2.73e-13 Schizophrenia; CRC trans rs561341 0.709 rs8068049 chr17:30183857 T/C cg27661571 chr11:113659931 NA 0.71 7.49 0.38 6.6e-13 Hip circumference adjusted for BMI; CRC cis rs8067545 0.562 rs2526481 chr17:20127018 T/C cg13482628 chr17:19912719 NA -0.47 -7.31 -0.37 2.01e-12 Schizophrenia; CRC trans rs61931739 0.500 rs11519398 chr12:34473553 C/T cg26384229 chr12:38710491 ALG10B 0.67 8.47 0.42 8.27e-16 Morning vs. evening chronotype; CRC cis rs11764590 0.671 rs62444906 chr7:2083161 G/T cg25834613 chr7:1915315 MAD1L1 -0.48 -6.84 -0.35 3.86e-11 Neuroticism; CRC cis rs798554 0.757 rs2533879 chr7:2859847 G/A cg19346786 chr7:2764209 NA -0.42 -7.28 -0.37 2.5e-12 Height; CRC cis rs12762955 0.561 rs1904671 chr10:1014603 G/A cg19847866 chr10:1019161 NA 0.43 6.39 0.33 5.76e-10 Response to angiotensin II receptor blocker therapy; CRC cis rs4713118 0.824 rs2179095 chr6:27750858 A/G cg26587870 chr6:27730563 NA 0.49 7.22 0.37 3.52e-12 Parkinson's disease; CRC cis rs2354432 0.556 rs7520661 chr1:146793149 A/G cg25205988 chr1:146714368 CHD1L -0.99 -8.1 -0.41 1.08e-14 Mitochondrial DNA levels; CRC cis rs6460942 0.915 rs80345607 chr7:12442249 T/C cg10578991 chr7:12443926 VWDE -0.51 -5.61 -0.3 4.29e-8 Coronary artery disease; CRC trans rs2303319 0.504 rs62189055 chr2:162625749 C/A cg22677401 chr17:46026860 NA -0.68 -6.15 -0.32 2.24e-9 Cognitive function; CRC cis rs10504229 0.683 rs10504221 chr8:58140256 A/G cg21724239 chr8:58056113 NA 0.49 6.81 0.35 4.75e-11 Developmental language disorder (linguistic errors); CRC cis rs6681460 0.674 rs2121051 chr1:67017177 G/A cg02459107 chr1:67143332 SGIP1 0.4 6.15 0.32 2.22e-9 Presence of antiphospholipid antibodies; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg22605943 chr3:107243790 BBX 0.48 6.84 0.35 3.77e-11 Response to antipsychotic treatment; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg22753607 chr9:37120306 ZCCHC7 0.43 6.05 0.32 3.91e-9 Response to antipsychotic treatment; CRC cis rs6502050 0.731 rs4789730 chr17:80145983 T/A cg02741985 chr17:80059408 CCDC57 0.44 7.15 0.37 5.55e-12 Life satisfaction; CRC cis rs10504229 0.639 rs11781834 chr8:58133422 C/T cg22535103 chr8:58192502 C8orf71 -0.71 -9.31 -0.46 1.82e-18 Developmental language disorder (linguistic errors); CRC cis rs7843479 0.965 rs13278159 chr8:21799737 C/A cg17168535 chr8:21777572 XPO7 0.59 9.58 0.47 2.5e-19 Mean corpuscular volume; CRC cis rs2019137 0.560 rs6707386 chr2:113981022 G/A cg21482265 chr2:113992762 PAX8;LOC440839;LOC654433 0.64 9.56 0.47 2.81e-19 Lymphocyte counts; CRC cis rs7811142 1.000 rs7803454 chr7:99991548 C/T cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.56 6.71 0.35 8.43e-11 Platelet count; CRC cis rs4268898 0.965 rs4665673 chr2:24459737 A/T cg06627628 chr2:24431161 ITSN2 0.49 7.28 0.37 2.55e-12 Asthma; CRC cis rs11696501 0.739 rs6017637 chr20:44264190 G/A cg11783356 chr20:44313418 WFDC10B -0.37 -5.65 -0.3 3.41e-8 Brain structure; CRC cis rs6502050 0.835 rs4789676 chr17:80123078 C/T cg02741985 chr17:80059408 CCDC57 0.43 7.15 0.37 5.59e-12 Life satisfaction; CRC cis rs7618501 1.000 rs7431106 chr3:49808374 G/A cg24308560 chr3:49941425 MST1R -0.46 -7.23 -0.37 3.51e-12 Intelligence (multi-trait analysis); CRC trans rs10507577 0.671 rs1418618 chr13:53938770 G/A cg06491101 chr5:39032016 RICTOR 0.44 5.97 0.31 6.17e-9 Select biomarker traits; CRC cis rs55702914 0.904 rs73050839 chr2:198231218 T/G cg10820045 chr2:198174542 NA 0.34 5.97 0.31 6.14e-9 Major depression and alcohol dependence; CRC cis rs9916302 0.706 rs8078599 chr17:37518660 C/T cg00129232 chr17:37814104 STARD3 0.56 6.6 0.34 1.62e-10 Glomerular filtration rate (creatinine); CRC cis rs6484504 0.532 rs12788257 chr11:31255045 T/C cg14844989 chr11:31128820 NA -0.34 -5.91 -0.31 8.67e-9 Red blood cell count; CRC cis rs9611565 0.512 rs45500192 chr22:42177899 A/G cg06634786 chr22:41940651 POLR3H -0.7 -7.73 -0.39 1.28e-13 Vitiligo; CRC trans rs7615952 0.546 rs2922194 chr3:125332263 G/A cg16558177 chr4:4109446 NA -0.56 -6.39 -0.33 5.52e-10 Blood pressure (smoking interaction); CRC cis rs10256972 0.591 rs10229680 chr7:1158565 C/T cg18402987 chr7:1209562 NA 0.49 6.97 0.36 1.75e-11 Longevity;Endometriosis; CRC cis rs9925964 0.933 rs4889530 chr16:31065918 T/A cg02466173 chr16:30829666 NA 0.4 5.62 0.3 4.1e-8 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs7772486 0.688 rs1884364 chr6:146337817 C/G cg23711669 chr6:146136114 FBXO30 0.54 7.93 0.4 3.56e-14 Lobe attachment (rater-scored or self-reported); CRC cis rs7617773 0.780 rs13067450 chr3:48337206 C/T cg11946769 chr3:48343235 NME6 0.73 9.93 0.48 1.73e-20 Coronary artery disease; CRC cis rs1949733 0.523 rs16842560 chr4:8544238 G/A cg11789530 chr4:8429930 ACOX3 -0.56 -7.66 -0.39 2.15e-13 Response to antineoplastic agents; CRC cis rs6061231 1.000 rs11908473 chr20:60957770 C/G cg22601191 chr20:60968625 CABLES2 0.45 7.38 0.38 1.3e-12 Colorectal cancer; CRC cis rs7085104 0.632 rs7096475 chr10:104609676 A/G cg04362960 chr10:104952993 NT5C2 0.58 8.48 0.42 7.96e-16 Immature fraction of reticulocytes;Schizophrenia; CRC cis rs4481887 0.927 rs10888344 chr1:248446655 T/C cg13385794 chr1:248469461 NA 0.37 6.56 0.34 2.14e-10 Common traits (Other); CRC cis rs7552404 0.731 rs61770552 chr1:76373050 T/C cg22875332 chr1:76189707 ACADM 0.63 7.67 0.39 2e-13 Blood metabolite levels;Acylcarnitine levels; CRC cis rs11212617 0.967 rs227061 chr11:108205329 A/G cg01991180 chr11:108092276 ATM;NPAT 0.41 6.02 0.32 4.56e-9 Response to metformin in type 2 diabetes (glycemic); CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg14272860 chr19:42580418 ZNF574 -0.42 -6.54 -0.34 2.38e-10 Myopia (pathological); CRC cis rs938554 0.744 rs6449137 chr4:9932479 A/T cg00071950 chr4:10020882 SLC2A9 -0.39 -5.71 -0.3 2.5e-8 Blood metabolite levels; CRC cis rs10464366 0.798 rs885352 chr7:39116168 A/G cg18850127 chr7:39170497 POU6F2 0.43 5.77 0.3 1.87e-8 IgG glycosylation; CRC cis rs2985684 0.895 rs4900940 chr14:50075310 A/C cg10008539 chr14:50087325 RPL36AL;MGAT2 -0.46 -6.04 -0.32 4.13e-9 Carotid intima media thickness; CRC cis rs116095464 0.614 rs56299325 chr5:220594 C/T cg22857025 chr5:266934 NA -1.23 -16.9 -0.68 1.4300000000000001e-46 Breast cancer; CRC trans rs10838798 0.523 rs11039593 chr11:48240112 A/G cg03929089 chr4:120376271 NA -0.46 -6.51 -0.34 2.73e-10 Height; CRC cis rs2070677 0.935 rs2070676 chr10:135351137 C/G cg16964102 chr10:135390573 NA -0.49 -6.9 -0.36 2.72e-11 Gout; CRC cis rs2251381 0.565 rs2832279 chr21:30613466 G/T cg08807101 chr21:30365312 RNF160 0.57 8.12 0.41 9.73e-15 Selective IgA deficiency; CRC cis rs727479 0.585 rs12911554 chr15:51542757 C/T cg19946085 chr15:51559439 CYP19A1 -0.28 -5.6 -0.3 4.48e-8 Estradiol levels; CRC cis rs7487075 0.859 rs3782904 chr12:46757985 T/C cg22049899 chr12:47219821 SLC38A4 0.34 6.77 0.35 6.09e-11 Itch intensity from mosquito bite; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg03827375 chr15:60771498 NARG2 0.4 6.3 0.33 9.68e-10 Liver disease severity in Alagille syndrome; CRC trans rs12188164 0.686 rs72711370 chr5:421057 A/C cg15371732 chr17:78194151 SLC26A11;SGSH 0.46 6.34 0.33 7.53e-10 Cystic fibrosis severity; CRC cis rs3818285 0.679 rs552419 chr10:111630883 G/T cg00817464 chr10:111662876 XPNPEP1 0.66 11.8 0.55 4.8e-27 Superior crus of antihelix expression; CRC cis rs67311347 1.000 rs6762251 chr3:40531136 A/G cg24209194 chr3:40518798 ZNF619 -0.38 -5.63 -0.3 3.78e-8 Renal cell carcinoma; CRC cis rs4713118 0.666 rs2893930 chr6:27738806 T/C cg02683197 chr6:28174875 NA 0.68 7.33 0.37 1.81e-12 Parkinson's disease; CRC cis rs3733585 0.699 rs6449179 chr4:9969117 G/A cg00071950 chr4:10020882 SLC2A9 -0.54 -9.63 -0.47 1.7e-19 Cleft plate (environmental tobacco smoke interaction); CRC trans rs9858542 0.953 rs9814873 chr3:49454112 A/G cg21582582 chr3:182698605 DCUN1D1 -0.51 -6.38 -0.33 6.14e-10 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs1865760 1.000 rs56118523 chr6:25908975 A/G cg16482183 chr6:26056742 HIST1H1C 0.54 7.81 0.4 7.71e-14 Height; CRC cis rs6951245 1.000 rs78143408 chr7:1096846 G/A cg18402987 chr7:1209562 NA 0.67 7.15 0.37 5.54e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs2011503 1.000 rs2965184 chr19:19545428 C/T cg11584989 chr19:19387371 SF4 -0.55 -6.26 -0.33 1.2e-9 Bipolar disorder; CRC cis rs4713118 0.513 rs149945 chr6:28002853 T/C cg02683197 chr6:28174875 NA 0.59 8.24 0.41 4.23e-15 Parkinson's disease; CRC cis rs35883536 0.514 rs4908062 chr1:101013211 T/C cg06223162 chr1:101003688 GPR88 0.42 7.83 0.4 6.9e-14 Monocyte count; CRC cis rs1568889 0.838 rs716366 chr11:28121536 T/C cg06544937 chr11:28130018 METT5D1;KIF18A 0.9 15.06 0.64 2.37e-39 Bipolar disorder; CRC cis rs35306767 0.761 rs11253558 chr10:1043983 T/C cg26597838 chr10:835615 NA 0.94 11.17 0.52 8.94e-25 Eosinophil percentage of granulocytes; CRC cis rs1348850 0.632 rs11682717 chr2:178499240 C/G cg02961200 chr2:178257176 LOC100130691;AGPS 0.62 8.81 0.44 7.22e-17 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs4862750 0.624 rs34414639 chr4:187873417 C/A cg11301795 chr4:187892539 NA -0.83 -17.8 -0.7 4.02e-50 Lobe attachment (rater-scored or self-reported); CRC cis rs11212617 1.000 rs227088 chr11:108243755 C/T cg01991180 chr11:108092276 ATM;NPAT 0.43 6.34 0.33 7.4e-10 Response to metformin in type 2 diabetes (glycemic); CRC cis rs10193935 0.892 rs7574609 chr2:42388468 C/A cg27598129 chr2:42591480 NA -0.65 -7.45 -0.38 8.36e-13 Colonoscopy-negative controls vs population controls; CRC cis rs6570726 0.791 rs10457788 chr6:145921136 T/A cg05347473 chr6:146136440 FBXO30 0.39 5.88 0.31 1.02e-8 Lobe attachment (rater-scored or self-reported); CRC cis rs4819052 0.851 rs914218 chr21:46698445 G/C cg11663144 chr21:46675770 NA -0.85 -14.49 -0.62 3.88e-37 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs1670533 1.000 rs11247971 chr4:1053580 A/G cg27284194 chr4:1044797 NA 0.49 6.06 0.32 3.75e-9 Recombination rate (females); CRC cis rs7932354 0.528 rs7937950 chr11:47098445 A/C cg03339077 chr11:47165057 C11orf49 0.43 5.99 0.31 5.58e-9 Bone mineral density (hip);Bone mineral density; CRC cis rs7618501 0.699 rs9821675 chr3:49902544 A/G cg05623727 chr3:50126028 RBM5 0.46 7.41 0.38 1.1e-12 Intelligence (multi-trait analysis); CRC cis rs2760061 0.545 rs1745423 chr1:228224153 G/T cg01200585 chr1:228362443 C1orf69 -0.46 -6.39 -0.33 5.67e-10 Diastolic blood pressure; CRC cis rs3617 0.625 rs7620690 chr3:52891707 A/G cg15147215 chr3:52552868 STAB1 0.53 9.14 0.45 6.61e-18 Red blood cell count;Autism spectrum disorder or schizophrenia; CRC cis rs2013441 1.000 rs12451216 chr17:20025840 C/A cg13482628 chr17:19912719 NA 0.4 6.26 0.33 1.19e-9 Obesity-related traits; CRC cis rs10504229 0.683 rs11774585 chr8:58132685 G/A cg05313129 chr8:58192883 C8orf71 -0.43 -6.11 -0.32 2.74e-9 Developmental language disorder (linguistic errors); CRC cis rs9322193 0.962 rs952165 chr6:150120036 T/C cg13206674 chr6:150067644 NUP43 0.57 8.14 0.41 8.29e-15 Lung cancer; CRC cis rs12711979 0.513 rs7566217 chr2:3851381 A/C cg17052675 chr2:3827356 NA -0.33 -5.84 -0.31 1.26e-8 Itch intensity from mosquito bite adjusted by bite size; CRC cis rs12893668 0.543 rs1799796 chr14:104165927 T/C cg08213375 chr14:104286397 PPP1R13B 0.46 7.43 0.38 9.15e-13 Reticulocyte count; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg24167606 chr3:183103843 MCF2L2 0.33 6.01 0.31 4.88e-9 Liver disease severity in Alagille syndrome; CRC cis rs11690935 0.959 rs10803863 chr2:172535337 T/C cg13550731 chr2:172543902 DYNC1I2 1.1 19.13 0.73 2.29e-55 Schizophrenia; CRC cis rs861020 1.000 rs674433 chr1:209964875 A/C cg05527609 chr1:210001259 C1orf107 -0.85 -11.05 -0.52 2.41e-24 Orofacial clefts; CRC cis rs7659604 0.539 rs3217753 chr4:122746325 A/G cg19748678 chr4:122722346 EXOSC9 0.64 10.18 0.49 2.46e-21 Type 2 diabetes; CRC trans rs2303319 0.504 rs55821334 chr2:162452014 A/G cg15664909 chr17:685709 GLOD4;RNMTL1 -0.67 -5.96 -0.31 6.48e-9 Cognitive function; CRC cis rs6460942 0.630 rs17671056 chr7:12390961 C/G cg20607287 chr7:12443886 VWDE -0.55 -5.82 -0.31 1.4e-8 Coronary artery disease; CRC cis rs2243480 1.000 rs313820 chr7:65574466 A/C cg18252515 chr7:66147081 NA -1.18 -13.88 -0.61 8.21e-35 Diabetic kidney disease; CRC cis rs7927592 0.913 rs10896346 chr11:68352671 C/T cg16797656 chr11:68205561 LRP5 0.36 5.73 0.3 2.27e-8 Total body bone mineral density; CRC cis rs6502050 0.835 rs4247357 chr17:80166989 G/T cg22110888 chr17:80059540 CCDC57 0.39 6.22 0.32 1.5e-9 Life satisfaction; CRC cis rs9611565 0.694 rs202628 chr22:41849513 A/G cg06634786 chr22:41940651 POLR3H -0.55 -6.75 -0.35 6.62e-11 Vitiligo; CRC cis rs3857067 1.000 rs3857067 chr4:95026434 A/T cg11021082 chr4:95130006 SMARCAD1 -0.39 -5.81 -0.31 1.48e-8 QT interval; CRC cis rs2836974 0.584 rs34436313 chr21:40685246 A/G cg11890956 chr21:40555474 PSMG1 -0.88 -14.09 -0.61 1.3e-35 Cognitive function; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg13099106 chr12:120525172 CCDC64 0.4 5.97 0.31 6.2e-9 Intelligence (multi-trait analysis); CRC cis rs67311347 1.000 rs9874499 chr3:40441908 C/T cg09455208 chr3:40491958 NA 0.42 8.44 0.42 9.98e-16 Renal cell carcinoma; CRC cis rs12477438 0.501 rs11123770 chr2:99825102 A/G cg26064155 chr2:99771622 LIPT1;TSGA10 0.69 11.24 0.53 5.17e-25 Chronic sinus infection; CRC cis rs1008375 0.966 rs7675735 chr4:17587137 T/A cg16339924 chr4:17578868 LAP3 0.6 7.89 0.4 4.4e-14 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs875971 1.000 rs12698523 chr7:65968113 C/G cg18912574 chr7:65842487 NCRNA00174 0.35 6.09 0.32 3.11e-9 Aortic root size; CRC cis rs2050392 0.792 rs9338188 chr10:30721963 G/C cg25182066 chr10:30743637 MAP3K8 -0.42 -6.15 -0.32 2.24e-9 Inflammatory bowel disease; CRC cis rs13191362 0.810 rs35509380 chr6:163053028 A/G cg06582575 chr6:163149167 PACRG;PARK2 0.92 11.54 0.54 4.15e-26 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs1577917 0.771 rs7742201 chr6:86432930 A/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.68 -9.08 -0.45 1.01e-17 Response to antipsychotic treatment; CRC cis rs28386778 0.897 rs7222189 chr17:61836372 T/C cg11494091 chr17:61959527 GH2 0.6 10.2 0.49 2.13e-21 Prudent dietary pattern; CRC cis rs2243480 1.000 rs313802 chr7:65516373 A/G cg25985355 chr7:65971099 NA -0.54 -6.14 -0.32 2.35e-9 Diabetic kidney disease; CRC cis rs2033711 0.870 rs1051500 chr19:58944402 A/G cg13877915 chr19:58951672 ZNF132 0.52 8.49 0.42 7.15e-16 Uric acid clearance; CRC cis rs7772486 0.806 rs7740785 chr6:146171299 C/A cg23711669 chr6:146136114 FBXO30 0.7 12.0 0.55 9.03e-28 Lobe attachment (rater-scored or self-reported); CRC cis rs6693567 0.565 rs3754214 chr1:150478623 T/C cg15654264 chr1:150340011 RPRD2 0.4 5.87 0.31 1.07e-8 Migraine; CRC cis rs1322639 0.806 rs1322640 chr6:169586887 T/C cg04662567 chr6:169592167 NA 0.48 7.75 0.39 1.17e-13 Pulse pressure; CRC cis rs10504229 1.000 rs67388517 chr8:58176617 C/A cg01721255 chr8:58191610 C8orf71 0.49 6.17 0.32 2e-9 Developmental language disorder (linguistic errors); CRC cis rs9787249 0.957 rs7518431 chr1:40214944 C/T cg01941586 chr1:40203715 PPIE 0.44 6.09 0.32 3.1e-9 Blood protein levels; CRC cis rs12594515 1.000 rs6493170 chr15:45987019 G/A cg19682013 chr15:45996608 NA 0.32 6.78 0.35 5.45e-11 Waist circumference;Weight; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg07333738 chr16:765560 METRN 0.38 6.09 0.32 3.23e-9 Liver disease severity in Alagille syndrome; CRC cis rs11785693 0.862 rs11782556 chr8:5002389 C/G cg26367366 chr8:4980734 NA 0.69 8.34 0.42 2.13e-15 Neuroticism (multi-trait analysis);Neuroticism; CRC cis rs2070488 1.000 rs6772046 chr3:38479660 C/T cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.85 15.79 0.66 3.44e-42 Electrocardiographic conduction measures; CRC cis rs4654899 0.680 rs4233274 chr1:21121678 C/T cg02927042 chr1:21476669 EIF4G3 -0.38 -5.96 -0.31 6.53e-9 Superior frontal gyrus grey matter volume; CRC cis rs9928842 0.765 rs4479268 chr16:75224733 G/T cg09066997 chr16:75300724 BCAR1 -0.65 -6.26 -0.33 1.18e-9 Alcoholic chronic pancreatitis; CRC cis rs2160860 0.773 rs11787449 chr8:39797174 A/G cg11363097 chr8:39792086 IDO2 -0.43 -7.3 -0.37 2.14e-12 Blood metabolite levels; CRC cis rs6860806 0.661 rs6871350 chr5:131580220 A/G cg22638593 chr5:131593259 PDLIM4 0.39 7.25 0.37 2.96e-12 Breast cancer; CRC cis rs172166 0.637 rs1225597 chr6:28162087 C/T cg12172441 chr6:28176163 NA 0.59 8.52 0.43 5.68e-16 Cardiac Troponin-T levels; CRC cis rs6495122 0.501 rs7163636 chr15:75346760 C/T cg17294928 chr15:75287854 SCAMP5 0.42 6.35 0.33 7.34e-10 Caffeine consumption;Diastolic blood pressure;Coffee consumption; CRC cis rs1881797 0.872 rs12408686 chr1:247691141 C/T cg05639522 chr1:247681581 NA 0.5 7.49 0.38 6.2e-13 Acute lymphoblastic leukemia (childhood); CRC cis rs8014204 0.753 rs6574199 chr14:75356103 T/C cg03030879 chr14:75389066 RPS6KL1 0.54 8.83 0.44 6.45e-17 Caffeine consumption; CRC cis rs2477686 0.526 rs2477690 chr1:2395563 G/A cg13556452 chr1:2391241 NA -0.39 -6.38 -0.33 5.92e-10 Non-obstructive azoospermia; CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg13038030 chr17:73267041 MIF4GD -0.52 -6.23 -0.32 1.46e-9 Diisocyanate-induced asthma; CRC cis rs9549367 0.713 rs3024745 chr13:113821598 A/G cg24300038 chr13:113819356 PROZ -0.47 -5.96 -0.31 6.67e-9 Platelet distribution width; CRC cis rs11039389 1 rs11039389 chr11:47796062 T/C cg05585544 chr11:47624801 NA -0.61 -10.7 -0.51 4.08e-23 Neuroticism; CRC cis rs6500602 0.826 rs9925719 chr16:4461861 A/G cg08645402 chr16:4508243 NA 0.56 7.69 0.39 1.67e-13 Schizophrenia; CRC cis rs4974559 0.947 rs28509315 chr4:1358107 C/T cg02980000 chr4:1222292 CTBP1 0.72 8.03 0.4 1.8e-14 Systolic blood pressure; CRC cis rs9910055 0.529 rs400460 chr17:42182770 A/G cg13607699 chr17:42295918 UBTF -0.47 -6.42 -0.33 4.67e-10 Total body bone mineral density; CRC cis rs2721195 0.967 rs10108150 chr8:145687475 A/G cg15320075 chr8:145703422 NA -0.55 -8.35 -0.42 1.97e-15 Age at first birth; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg17408923 chr2:109335769 RANBP2 0.52 7.38 0.38 1.26e-12 Response to antipsychotic treatment; CRC cis rs977987 0.806 rs8050059 chr16:75388731 C/T cg03315344 chr16:75512273 CHST6 0.52 8.74 0.43 1.22e-16 Dupuytren's disease; CRC cis rs769267 0.965 rs1010207 chr19:19416045 T/C cg17414380 chr19:19431394 KIAA0892;SF4 0.42 5.68 0.3 2.89e-8 Tonsillectomy; CRC cis rs4665809 0.887 rs2384324 chr2:26354239 A/G cg04944784 chr2:26401820 FAM59B -0.68 -8.53 -0.43 5.51e-16 Gut microbiome composition (summer); CRC cis rs2032447 0.899 rs1090947 chr6:26076642 T/C cg04800585 chr6:26043546 HIST1H2BB 0.51 7.6 0.39 3.2e-13 Intelligence (multi-trait analysis); CRC cis rs8060686 0.920 rs73594581 chr16:67955554 G/A cg19582491 chr16:67682965 RLTPR -0.58 -6.7 -0.35 9.02e-11 HDL cholesterol;Metabolic syndrome; CRC cis rs7769051 0.522 rs60631157 chr6:133094817 G/A cg22852734 chr6:133119734 C6orf192 0.96 8.82 0.44 7.07e-17 Type 2 diabetes nephropathy; CRC cis rs6921919 0.697 rs12180820 chr6:28316478 A/G cg15845792 chr6:28175446 NA -0.47 -6.53 -0.34 2.54e-10 Autism spectrum disorder or schizophrenia; CRC cis rs9733 0.596 rs72702504 chr1:150635374 G/C cg18016565 chr1:150552671 MCL1 0.46 6.74 0.35 6.91e-11 Tonsillectomy; CRC cis rs4665809 1.000 rs1550382 chr2:26266877 T/G cg25036284 chr2:26402008 FAM59B -0.46 -6.02 -0.32 4.53e-9 Gut microbiome composition (summer); CRC cis rs2836950 0.520 rs59916147 chr21:40634702 T/G cg06238570 chr21:40685208 BRWD1 -0.64 -9.28 -0.46 2.29e-18 Menarche (age at onset); CRC cis rs2180341 0.618 rs4502958 chr6:127593113 G/A cg24812749 chr6:127587940 RNF146 0.63 9.41 0.46 8.71e-19 Breast cancer; CRC cis rs11785400 0.701 rs9721143 chr8:143727511 A/T cg24634471 chr8:143751801 JRK 0.51 7.08 0.36 8.81e-12 Schizophrenia; CRC cis rs8180040 0.691 rs12489211 chr3:47221451 T/A cg02527881 chr3:46936655 PTH1R -0.4 -7.48 -0.38 6.62e-13 Colorectal cancer; CRC cis rs34779708 0.931 rs12261654 chr10:35322024 G/A cg03585969 chr10:35415529 CREM 0.57 7.65 0.39 2.26e-13 Inflammatory bowel disease;Crohn's disease; CRC trans rs11098499 0.645 rs78422072 chr4:120281042 C/T cg25214090 chr10:38739885 LOC399744 0.6 9.39 0.46 1.01e-18 Corneal astigmatism; CRC cis rs12760731 0.641 rs11588490 chr1:178328139 T/A cg00404053 chr1:178313656 RASAL2 0.94 9.89 0.48 2.37e-20 Obesity-related traits; CRC cis rs2857891 0.909 rs56372435 chr11:6938658 T/C cg14883916 chr11:6947541 ZNF215 0.59 6.26 0.33 1.21e-9 Response to cytadine analogues (cytosine arabinoside); CRC cis rs8078723 0.933 rs55846942 chr17:38164470 G/A cg17467752 chr17:38218738 THRA 0.73 12.0 0.55 9.38e-28 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); CRC cis rs713587 0.776 rs2118826 chr2:25191745 A/T cg22495460 chr2:25135724 ADCY3 0.66 10.56 0.5 1.24e-22 Body mass index in non-asthmatics; CRC cis rs853679 0.550 rs1233699 chr6:28169158 A/T cg02683197 chr6:28174875 NA 0.9 12.58 0.57 6.51e-30 Depression; CRC cis rs853679 0.545 rs35949109 chr6:28025926 T/C cg15845792 chr6:28175446 NA 0.77 6.87 0.35 3.26e-11 Depression; CRC cis rs7914558 0.966 rs1971589 chr10:104744406 A/G cg15744005 chr10:104629667 AS3MT -0.35 -7.5 -0.38 5.82e-13 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs950169 0.580 rs4603535 chr15:85173872 C/T cg11189052 chr15:85197271 WDR73 0.64 9.35 0.46 1.35e-18 Schizophrenia; CRC cis rs13256369 1.000 rs1109619 chr8:8571616 G/T cg00074818 chr8:8560427 CLDN23 0.4 7.42 0.38 9.98e-13 Obesity-related traits; CRC cis rs447 0.943 rs10808306 chr7:83767093 G/A cg22846510 chr7:83753280 SEMA3A -0.61 -7.77 -0.39 9.88e-14 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs9837602 1.000 rs9878931 chr3:99712634 G/A cg07805332 chr3:99536008 MIR548G;C3orf26 -0.47 -6.2 -0.32 1.65e-9 Breast cancer; CRC cis rs2479724 0.901 rs6458244 chr6:41790455 C/T cg17623882 chr6:41773611 USP49 0.55 9.41 0.46 8.58e-19 Menarche (age at onset); CRC cis rs9910055 0.529 rs228766 chr17:42186813 A/G cg10896456 chr17:42255109 ASB16;C17orf65 -0.38 -5.77 -0.3 1.88e-8 Total body bone mineral density; CRC cis rs10540 0.730 rs34690033 chr11:492677 G/C cg15790184 chr11:494944 RNH1 0.6 6.17 0.32 2.01e-9 Body mass index; CRC cis rs7618915 0.547 rs2164884 chr3:52629633 C/T cg18099408 chr3:52552593 STAB1 -0.44 -7.27 -0.37 2.7e-12 Bipolar disorder; CRC cis rs9487051 0.807 rs7748641 chr6:109592381 C/T cg21918786 chr6:109611834 NA -0.44 -7.99 -0.4 2.37e-14 Reticulocyte fraction of red cells; CRC cis rs992157 0.767 rs2382822 chr2:219173327 T/C cg04731861 chr2:219085781 ARPC2 0.31 6.2 0.32 1.69e-9 Colorectal cancer; CRC cis rs10832963 1.000 rs4757676 chr11:18640477 C/T cg09201001 chr11:18656081 SPTY2D1 0.8 12.48 0.57 1.55e-29 Breast cancer; CRC cis rs10791323 0.604 rs2853116 chr11:133707063 A/G cg00579200 chr11:133705235 NA -0.41 -5.82 -0.31 1.36e-8 Childhood ear infection; CRC cis rs9462027 0.606 rs2814987 chr6:34605145 G/A cg07306190 chr6:34760872 UHRF1BP1 -0.35 -6.31 -0.33 9.16e-10 Systemic lupus erythematosus; CRC cis rs9491140 0.539 rs12210199 chr6:124684045 C/A cg22366943 chr6:124882293 NKAIN2 0.55 8.02 0.4 1.93e-14 Neuroticism; CRC trans rs8123881 0.733 rs7268466 chr20:15810676 C/T cg22876561 chr7:11013721 PHF14 0.55 6.39 0.33 5.82e-10 Body mass index; CRC cis rs4713118 0.869 rs9283883 chr6:27715470 T/A cg08798685 chr6:27730294 NA -0.43 -6.17 -0.32 2.02e-9 Parkinson's disease; CRC cis rs10504229 0.683 rs11786074 chr8:58133532 A/G cg04204079 chr8:58130323 NA -0.45 -5.78 -0.3 1.71e-8 Developmental language disorder (linguistic errors); CRC cis rs7945705 0.967 rs34842234 chr11:8891894 G/A cg12365402 chr11:9010492 NRIP3 0.47 7.62 0.39 2.67e-13 Hemoglobin concentration; CRC cis rs7103648 0.966 rs1377416 chr11:47416746 C/T cg20307385 chr11:47447363 PSMC3 0.97 17.69 0.7 1.07e-49 Diastolic blood pressure;Systolic blood pressure; CRC cis rs539514 0.690 rs2761398 chr13:76316933 C/A cg04757411 chr13:76259545 LMO7 -0.34 -5.78 -0.3 1.75e-8 Type 1 diabetes; CRC cis rs1046896 0.553 rs2292965 chr17:80900645 G/A cg16060761 chr17:80687452 NA -0.49 -6.51 -0.34 2.89e-10 Glycated hemoglobin levels; CRC cis rs7208859 0.623 rs11658022 chr17:29085359 A/T cg01831904 chr17:28903510 LRRC37B2 -0.66 -6.75 -0.35 6.59e-11 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg18426345 chr19:19516893 GATAD2A 0.44 6.48 0.34 3.36e-10 Intelligence (multi-trait analysis); CRC cis rs904251 0.523 rs2797799 chr6:37483620 T/G cg25019722 chr6:37503610 NA -0.47 -8.78 -0.44 9.33e-17 Cognitive performance; CRC cis rs9322193 0.884 rs7769115 chr6:150169932 C/T cg13206674 chr6:150067644 NUP43 0.58 8.26 0.41 3.68e-15 Lung cancer; CRC cis rs6088813 1.000 rs4911491 chr20:33947285 C/G cg14752227 chr20:34000481 UQCC -0.37 -5.82 -0.31 1.37e-8 Height; CRC cis rs7119 0.651 rs8041520 chr15:77839169 C/T cg27398640 chr15:77910606 LINGO1 -0.43 -7.28 -0.37 2.42e-12 Type 2 diabetes; CRC cis rs3736485 0.932 rs4774598 chr15:51919667 G/A cg08986416 chr15:51914746 DMXL2 -0.45 -6.4 -0.33 5.23e-10 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs7829975 0.714 rs12544992 chr8:8661681 C/G cg08975724 chr8:8085496 FLJ10661 0.45 6.97 0.36 1.69e-11 Mood instability; CRC cis rs11971779 0.680 rs10242419 chr7:139089380 A/G cg07862535 chr7:139043722 LUC7L2 -0.57 -7.36 -0.38 1.48e-12 Diisocyanate-induced asthma; CRC trans rs8100891 0.537 rs73038232 chr19:32987653 C/T cg08611549 chr12:108064394 NA 0.37 6.16 0.32 2.13e-9 Neuroticism; CRC cis rs9640161 0.750 rs11764936 chr7:150025915 G/T cg13722127 chr7:150037890 RARRES2 0.5 8.05 0.41 1.58e-14 Blood protein levels;Circulating chemerin levels; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg14914809 chr2:171705073 GAD1 0.39 6.12 0.32 2.68e-9 Liver disease severity in Alagille syndrome; CRC cis rs61996546 0.622 rs4542636 chr15:26867931 C/T cg15066197 chr15:26874202 GABRB3 -0.39 -6.02 -0.31 4.69e-9 Response to methotrexate in juvenile idiopathic arthritis; CRC cis rs9311474 0.659 rs7638808 chr3:52572056 C/T cg18099408 chr3:52552593 STAB1 0.54 9.67 0.47 1.2e-19 Electroencephalogram traits; CRC cis rs3741404 0.825 rs11604782 chr11:63946650 G/A cg18225595 chr11:63971243 STIP1 0.66 10.68 0.51 4.82e-23 Platelet count; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg03774484 chr12:7079822 PHB2;EMG1 -0.4 -5.97 -0.31 6.04e-9 Myopia (pathological); CRC cis rs951366 0.789 rs823094 chr1:205689807 G/T cg07157834 chr1:205819609 PM20D1 -0.75 -11.84 -0.55 3.46e-27 Menarche (age at onset); CRC cis rs11098499 0.648 rs2002047 chr4:120257228 A/G cg24375607 chr4:120327624 NA 0.47 7.45 0.38 8.16e-13 Corneal astigmatism; CRC cis rs6546550 0.935 rs1531025 chr2:70055505 G/T cg02498382 chr2:70120550 SNRNP27 -0.49 -8.31 -0.42 2.47e-15 Prevalent atrial fibrillation; CRC cis rs3796352 0.764 rs34872575 chr3:52986277 G/A cg07884673 chr3:53033167 SFMBT1 0.76 6.13 0.32 2.45e-9 Immune reponse to smallpox (secreted IL-2); CRC cis rs9660992 0.649 rs12128254 chr1:205268097 C/T cg21643547 chr1:205240462 TMCC2 -0.43 -6.78 -0.35 5.71e-11 Mean corpuscular volume;Mean platelet volume; CRC cis rs4727027 0.933 rs10238826 chr7:148830888 A/G cg12479418 chr7:148823350 ZNF425;ZNF398 0.42 5.75 0.3 2.05e-8 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC cis rs3824347 0.839 rs12553648 chr9:77570716 A/G cg01251476 chr9:77566080 C9orf40 -0.4 -6.27 -0.33 1.15e-9 Urinary magnesium-to-creatinine ratio; CRC cis rs8180040 0.764 rs11718795 chr3:47218727 G/A cg10298567 chr3:47292165 KIF9 -0.36 -5.89 -0.31 9.67e-9 Colorectal cancer; CRC trans rs13046373 0.905 rs4816372 chr21:32077414 A/T cg26688472 chr2:203638928 ICA1L -0.43 -6.43 -0.33 4.51e-10 HDL cholesterol; CRC cis rs9420 0.961 rs11606396 chr11:57435211 C/T cg23127183 chr11:57508653 C11orf31 -0.53 -7.14 -0.37 6.16e-12 Schizophrenia; CRC cis rs6951245 0.938 rs117729148 chr7:1108531 G/A cg24642844 chr7:1081250 C7orf50 -0.77 -9.29 -0.46 2.23e-18 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs4077515 0.577 rs3812584 chr9:139312719 C/T cg14019695 chr9:139328340 INPP5E -0.42 -6.23 -0.32 1.46e-9 Ulcerative colitis;IgA nephropathy;Inflammatory bowel disease;Crohn's disease; CRC cis rs28386778 0.863 rs9207 chr17:61823899 C/T cg25654072 chr17:61904446 PSMC5;FTSJ3 0.71 11.13 0.52 1.23e-24 Prudent dietary pattern; CRC cis rs13090388 1 rs13090388 chr3:49391082 C/T cg03060546 chr3:49711283 APEH -0.49 -6.83 -0.35 4.18e-11 Intelligence (multi-trait analysis);Educational attainment (years of education); CRC cis rs12122100 0.526 rs12122534 chr1:146504399 A/G cg02487331 chr1:146550467 NA 0.32 5.8 0.3 1.56e-8 HIV-1 control; CRC cis rs2013441 1.000 rs17686798 chr17:20029170 A/C cg13482628 chr17:19912719 NA -0.38 -5.84 -0.31 1.26e-8 Obesity-related traits; CRC cis rs6952808 0.609 rs11772205 chr7:1951236 C/T cg02951883 chr7:2050386 MAD1L1 -0.54 -8.87 -0.44 4.73e-17 Bipolar disorder and schizophrenia; CRC cis rs11252926 0.528 rs11252090 chr10:436547 C/T cg16386425 chr10:429943 DIP2C 0.42 6.2 0.32 1.71e-9 Psychosis in Alzheimer's disease; CRC cis rs28386778 0.863 rs8076760 chr17:61920497 T/C cg25654072 chr17:61904446 PSMC5;FTSJ3 0.72 11.16 0.52 9.37e-25 Prudent dietary pattern; CRC cis rs7618915 0.501 rs1866268 chr3:52719398 C/A cg05573699 chr3:52720067 GNL3;PBRM1 -0.49 -7.24 -0.37 3.29e-12 Bipolar disorder; CRC cis rs10979 1.000 rs9386038 chr6:143896358 A/G cg25407410 chr6:143891975 LOC285740 -0.84 -13.84 -0.61 1.22e-34 Hypospadias; CRC cis rs4820539 1.000 rs4822360 chr22:23482460 A/G cg14186256 chr22:23484241 RTDR1 0.89 17.06 0.69 3.26e-47 Bone mineral density; CRC cis rs9905704 0.881 rs695137 chr17:56776663 G/A cg12560992 chr17:57184187 TRIM37 0.53 7.37 0.38 1.41e-12 Testicular germ cell tumor; CRC cis rs1953600 0.805 rs2819947 chr10:81947757 T/C cg04850286 chr10:81895943 PLAC9 0.36 6.35 0.33 6.97e-10 Sarcoidosis; CRC cis rs10489202 0.608 rs10918826 chr1:168075316 C/T cg24449463 chr1:168025552 DCAF6 -0.52 -7.54 -0.38 4.57e-13 Schizophrenia; CRC cis rs10751667 0.643 rs6597969 chr11:928843 C/T cg23136738 chr11:925521 AP2A2 -0.41 -6.8 -0.35 4.92e-11 Alzheimer's disease (late onset); CRC cis rs5769765 0.720 rs138820 chr22:50164078 A/G cg22709217 chr22:50311962 ALG12;CRELD2 -0.8 -11.85 -0.55 3.26e-27 Schizophrenia; CRC cis rs12477438 0.798 rs1453561 chr2:99613924 C/T cg14399236 chr2:99771627 LIPT1;TSGA10 -0.71 -9.9 -0.48 2.1e-20 Chronic sinus infection; CRC cis rs67340775 0.541 rs200964 chr6:27866943 G/C cg15786705 chr6:28176104 NA 0.57 5.78 0.3 1.77e-8 Lung cancer in ever smokers; CRC cis rs6694672 0.867 rs2336595 chr1:197000476 T/C cg13682187 chr1:196946512 CFHR5 0.47 7.32 0.37 1.88e-12 Asthma; CRC cis rs12983728 1.000 rs12983728 chr19:58671267 G/A cg08687515 chr19:58661962 ZNF329 0.75 8.17 0.41 6.84e-15 Cholesterol, total; CRC cis rs490234 0.756 rs925473 chr9:128228026 A/G cg14078157 chr9:128172775 NA -0.39 -6.51 -0.34 2.81e-10 Mean arterial pressure; CRC cis rs9486719 0.947 rs11755945 chr6:96908038 G/C cg18709589 chr6:96969512 KIAA0776 -0.52 -5.79 -0.3 1.62e-8 Migraine;Coronary artery disease; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg14056668 chr15:52122448 TMOD3 0.42 5.97 0.31 6.03e-9 Intelligence (multi-trait analysis); CRC cis rs8060686 0.858 rs6499143 chr16:67874264 T/C cg07125278 chr16:67683757 RLTPR -0.48 -6.64 -0.34 1.29e-10 HDL cholesterol;Metabolic syndrome; CRC cis rs1005277 0.579 rs2474594 chr10:38426661 G/C cg00409905 chr10:38381863 ZNF37A -0.67 -11.17 -0.52 9.18e-25 Extrinsic epigenetic age acceleration; CRC cis rs3733585 0.725 rs10939636 chr4:9972640 T/G cg11266682 chr4:10021025 SLC2A9 -0.46 -9.33 -0.46 1.62e-18 Cleft plate (environmental tobacco smoke interaction); CRC cis rs1190552 0.706 rs2146426 chr14:102995068 A/G cg18135206 chr14:102964638 TECPR2 0.49 6.06 0.32 3.8e-9 Blood protein levels; CRC cis rs9322193 0.884 rs10782312 chr6:149943805 G/T cg00933542 chr6:150070202 PCMT1 0.29 6.08 0.32 3.37e-9 Lung cancer; CRC cis rs7124681 0.565 rs2904127 chr11:47817290 A/G cg20307385 chr11:47447363 PSMC3 0.46 6.64 0.34 1.33e-10 Body mass index (joint analysis main effects and physical activity interaction);Body mass index;Body mass index in physically active individuals; CRC cis rs6903823 0.527 rs4713158 chr6:28277771 C/A cg21251018 chr6:28226885 NKAPL 0.54 8.9 0.44 3.72e-17 Pulmonary function; CRC cis rs3806843 0.576 rs246006 chr5:140339228 G/A cg19875535 chr5:140030758 IK 0.4 6.12 0.32 2.64e-9 Depressive symptoms (multi-trait analysis); CRC cis rs6570726 0.935 rs585292 chr6:145862228 T/C cg23711669 chr6:146136114 FBXO30 0.7 12.46 0.57 1.8e-29 Lobe attachment (rater-scored or self-reported); CRC cis rs9486715 1.000 rs11153085 chr6:97066355 A/T cg06623918 chr6:96969491 KIAA0776 -0.9 -14.88 -0.63 1.14e-38 Headache; CRC cis rs11098499 0.863 rs1010739 chr4:120463471 C/T cg24375607 chr4:120327624 NA 0.46 7.04 0.36 1.15e-11 Corneal astigmatism; CRC cis rs13082711 0.520 rs12486671 chr3:27556832 A/G cg02860705 chr3:27208620 NA 0.41 6.08 0.32 3.34e-9 Systolic blood pressure;Diastolic blood pressure;Blood pressure; CRC cis rs875971 0.642 rs35526611 chr7:66094008 C/T cg25985355 chr7:65971099 NA 0.32 5.69 0.3 2.8e-8 Aortic root size; CRC cis rs1129187 0.755 rs9471982 chr6:42935998 G/A cg02353165 chr6:42928485 GNMT 0.69 11.52 0.54 4.96e-26 Alzheimer's disease in APOE e4+ carriers; CRC cis rs66569888 0.507 rs11673736 chr2:106886935 T/C cg15412446 chr2:106886593 NA -0.75 -14.1 -0.61 1.26e-35 Facial morphology (factor 23); CRC cis rs908922 0.676 rs908927 chr1:152513338 C/G cg09873164 chr1:152488093 CRCT1 0.4 6.6 0.34 1.66e-10 Hair morphology; CRC cis rs370915 0.963 rs59452206 chr4:187816484 G/T cg19519643 chr4:187840862 NA -0.41 -5.84 -0.31 1.23e-8 Gout; CRC cis rs919433 0.756 rs7575389 chr2:198198489 A/G cg03934865 chr2:198174659 NA -0.38 -6.13 -0.32 2.52e-9 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC trans rs4853036 0.629 rs34704699 chr2:70014710 G/A cg14633329 chr9:139640053 LCN6 -0.37 -6.2 -0.32 1.66e-9 Colorectal or endometrial cancer; CRC cis rs1215050 0.740 rs783945 chr4:99014394 G/A cg05340658 chr4:99064831 C4orf37 -0.49 -7.41 -0.38 1.09e-12 Waist-to-hip ratio adjusted for body mass index; CRC cis rs61160187 0.582 rs72757187 chr5:60263766 T/A cg16298547 chr5:60138761 ELOVL7 -0.27 -5.74 -0.3 2.15e-8 Educational attainment (years of education);Educational attainment (college completion); CRC cis rs4780355 0.843 rs243325 chr16:11354497 A/G cg00044050 chr16:11439710 C16orf75 0.4 5.69 0.3 2.83e-8 Crohn's disease and psoriasis; CRC trans rs17065417 1.000 rs1149280 chr6:105454799 T/A cg03946762 chr12:54785043 ZNF385A -0.55 -6.25 -0.33 1.31e-9 Neuroblastoma;Sporadic neuroblastoma; CRC cis rs6807306 1.000 rs2420025 chr3:167368802 A/C cg18801567 chr3:167450363 PDCD10 -0.39 -5.65 -0.3 3.41e-8 Mean platelet volume; CRC cis rs1552244 0.938 rs9873794 chr3:10074153 T/G cg00166722 chr3:10149974 C3orf24 0.65 8.96 0.44 2.39e-17 Alzheimer's disease; CRC cis rs9929218 0.954 rs9646284 chr16:68791306 C/G cg02972257 chr16:68554789 NA 0.45 5.73 0.3 2.27e-8 Colorectal cancer; CRC cis rs172166 0.694 rs203892 chr6:28067196 T/C cg02683197 chr6:28174875 NA 0.67 9.18 0.45 4.91e-18 Cardiac Troponin-T levels; CRC cis rs2180341 0.924 rs6930849 chr6:127630963 A/T cg24812749 chr6:127587940 RNF146 0.95 13.71 0.6 3.81e-34 Breast cancer; CRC cis rs3736485 0.966 rs10467923 chr15:51767265 A/C cg08986416 chr15:51914746 DMXL2 -0.43 -6.12 -0.32 2.69e-9 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs4660531 1.000 rs4660531 chr1:41839822 G/T cg19619003 chr1:41846758 NA -0.38 -5.92 -0.31 8.08e-9 Bipolar disorder; CRC cis rs9534288 0.762 rs3934247 chr13:46549137 C/T cg15192986 chr13:46630673 CPB2 -0.64 -9.45 -0.46 6.39e-19 Blood protein levels; CRC cis rs751728 0.865 rs751726 chr6:33764386 G/A cg25922239 chr6:33757077 LEMD2 0.62 9.84 0.48 3.5e-20 Crohn's disease; CRC cis rs2658782 0.950 rs2446061 chr11:93149277 C/T cg21115391 chr11:93143810 CCDC67 -0.4 -5.91 -0.31 8.77e-9 Pulmonary function decline; CRC cis rs77633900 0.772 rs8031378 chr15:76657874 A/G cg21673338 chr15:77095150 SCAPER -0.71 -6.52 -0.34 2.59e-10 Non-glioblastoma glioma;Glioma; CRC cis rs9303401 0.659 rs36093395 chr17:56957357 C/T cg10487724 chr17:56770010 TEX14;RAD51C 0.76 9.53 0.47 3.57e-19 Cognitive test performance; CRC cis rs4638749 0.677 rs4396668 chr2:108840364 C/T cg25838818 chr2:108905173 SULT1C2 -0.34 -5.72 -0.3 2.33e-8 Blood pressure; CRC cis rs7617773 0.817 rs79310258 chr3:48259667 C/G cg11946769 chr3:48343235 NME6 0.73 9.78 0.47 5.46e-20 Coronary artery disease; CRC cis rs853679 0.607 rs201002 chr6:27808192 A/G cg08798685 chr6:27730294 NA -0.61 -5.93 -0.31 7.55e-9 Depression; CRC cis rs1030268 0.651 rs13222377 chr7:133466346 C/T cg10665199 chr7:133106180 EXOC4 0.52 6.09 0.32 3.09e-9 Intelligence (multi-trait analysis); CRC cis rs10256972 0.732 rs12701856 chr7:1107707 C/T cg18402987 chr7:1209562 NA 0.44 6.48 0.34 3.28e-10 Longevity;Endometriosis; CRC cis rs6121246 0.529 rs58757492 chr20:30181425 G/A cg18721089 chr20:30220636 NA -0.53 -8.03 -0.4 1.78e-14 Mean corpuscular hemoglobin; CRC trans rs11098499 0.954 rs12502423 chr4:120424172 A/C cg25214090 chr10:38739885 LOC399744 0.64 9.87 0.48 2.62e-20 Corneal astigmatism; CRC trans rs12483148 1.000 rs12483148 chr21:37013621 T/C cg02629111 chr21:18966031 BTG3 0.72 6.12 0.32 2.63e-9 Obesity-related traits; CRC cis rs477895 0.653 rs34113693 chr11:63900123 G/T cg05016508 chr11:63871570 FLRT1;MACROD1 0.53 6.83 0.35 4.22e-11 Mean platelet volume; CRC cis rs8062405 0.964 rs11860513 chr16:28825420 C/T cg16576597 chr16:28551801 NUPR1 0.5 7.26 0.37 2.83e-12 Cognitive ability (multi-trait analysis);Cognitive ability; CRC cis rs12541335 0.639 rs4871994 chr8:22206038 G/A cg09517075 chr8:22133004 PIWIL2 0.48 8.2 0.41 5.35e-15 Hypertriglyceridemia; CRC cis rs4243830 0.850 rs1114661 chr1:6596871 G/A cg05709478 chr1:6581295 PLEKHG5 -0.59 -7.02 -0.36 1.25e-11 Body mass index; CRC cis rs1150688 1 rs1150688 chr6:28162780 T/C cg21251018 chr6:28226885 NKAPL 0.59 10.3 0.49 9.21e-22 Autism spectrum disorder or schizophrenia; CRC cis rs7552404 0.924 rs2153126 chr1:76199345 C/G cg22875332 chr1:76189707 ACADM 0.8 12.0 0.55 9.4e-28 Blood metabolite levels;Acylcarnitine levels; CRC trans rs4332037 0.826 rs4721188 chr7:1953615 G/A cg11693508 chr17:37793320 STARD3 -0.61 -7.49 -0.38 6.47e-13 Bipolar disorder; CRC cis rs847649 0.731 rs13222980 chr7:102703898 A/G cg18108683 chr7:102477205 FBXL13 0.52 8.2 0.41 5.36e-15 Morning vs. evening chronotype; CRC cis rs6479527 0.875 rs10761313 chr9:96770793 T/C cg14459158 chr9:96720562 NA 0.4 7.07 0.36 9.13e-12 Esophageal adenocarcinoma; CRC cis rs4077468 0.963 rs1342064 chr1:205913073 T/C cg13172432 chr1:205912842 SLC26A9 -0.33 -5.81 -0.3 1.5e-8 Cystic fibrosis-related diabetes; CRC cis rs11122272 0.525 rs61835222 chr1:231537917 C/A cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.57 -8.56 -0.43 4.41e-16 Hemoglobin concentration; CRC cis rs898097 0.805 rs60233158 chr17:80896612 A/G cg15664640 chr17:80829946 TBCD 0.65 10.47 0.5 2.56e-22 Breast cancer; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg11138794 chr3:122283215 PARP9;DTX3L 0.43 6.92 0.36 2.43e-11 Liver disease severity in Alagille syndrome; CRC cis rs3018066 0.666 rs12643397 chr4:107054976 G/C cg01869342 chr4:106983673 TBCK 0.43 5.75 0.3 2e-8 Cancer; CRC cis rs3858526 0.523 rs10769287 chr11:5884845 T/C cg26762873 chr11:5879799 OR52E8 -0.49 -7.55 -0.38 4.24e-13 DNA methylation (variation); CRC trans rs6598955 0.671 rs11247910 chr1:26645666 G/A cg07461501 chr17:79650226 HGS;ARL16 -0.55 -6.29 -0.33 9.89e-10 Obesity-related traits; CRC cis rs60871478 0.635 rs4311567 chr7:792295 T/C cg13844804 chr7:814759 HEATR2 0.68 7.92 0.4 3.65e-14 Cerebrospinal P-tau181p levels; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg14614337 chr9:131533978 ZER1 0.45 6.71 0.35 8.46e-11 Intelligence (multi-trait analysis); CRC cis rs2839186 0.933 rs56955294 chr21:47708953 A/G cg02776659 chr21:47717406 C21orf57 -0.34 -5.62 -0.3 4.13e-8 Testicular germ cell tumor; CRC cis rs9611565 0.503 rs5751156 chr22:42170025 A/G cg03806693 chr22:41940476 POLR3H 1.1 13.49 0.6 2.68e-33 Vitiligo; CRC cis rs4242434 0.536 rs1871900 chr8:22481449 A/G cg03733263 chr8:22462867 KIAA1967 0.68 11.01 0.52 3.14e-24 Exploratory eye movement dysfunction in schizophrenia (cognitive search score); CRC cis rs2239547 0.657 rs7638524 chr3:52874861 G/A cg15147215 chr3:52552868 STAB1 -0.42 -5.84 -0.31 1.28e-8 Schizophrenia; CRC cis rs6543140 0.855 rs4851591 chr2:103077423 T/C cg03938978 chr2:103052716 IL18RAP 0.41 6.54 0.34 2.37e-10 Blood protein levels; CRC cis rs2976388 1.000 rs2976396 chr8:143764001 A/G cg20041105 chr8:143859282 LYNX1 0.32 5.73 0.3 2.31e-8 Urinary tract infection frequency; CRC trans rs10802346 0.524 rs10802356 chr1:246385857 T/C cg13514129 chr1:39547527 MACF1 0.64 9.77 0.47 6e-20 Fractional exhaled nitric oxide (childhood); CRC cis rs7945718 0.839 rs2033908 chr11:12838286 G/T cg25843174 chr11:12811716 TEAD1 0.46 8.58 0.43 3.71e-16 Educational attainment (years of education); CRC cis rs9487051 0.872 rs9487043 chr6:109610474 C/T cg01475377 chr6:109611718 NA -0.48 -8.84 -0.44 5.78e-17 Reticulocyte fraction of red cells; CRC cis rs4665809 1.000 rs2384323 chr2:26306473 C/T cg25036284 chr2:26402008 FAM59B -0.46 -6.02 -0.31 4.67e-9 Gut microbiome composition (summer); CRC cis rs3015497 0.586 rs7144714 chr14:51078585 G/A cg09863266 chr14:51125203 SAV1 -0.3 -5.7 -0.3 2.66e-8 Mean platelet volume; CRC trans rs7267979 0.844 rs2474780 chr20:25285835 G/A cg17903999 chr18:56338584 MALT1 -0.43 -6.91 -0.36 2.48e-11 Liver enzyme levels (alkaline phosphatase); CRC cis rs3091242 0.809 rs660129 chr1:25727438 C/T cg27572855 chr1:25598939 RHD 0.35 6.07 0.32 3.43e-9 Erythrocyte sedimentation rate; CRC cis rs2019137 0.560 rs10175462 chr2:113988492 G/A cg17445212 chr2:113993313 PAX8;LOC440839;LOC654433 0.47 7.35 0.38 1.63e-12 Lymphocyte counts; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg15229027 chr14:64805542 ESR2 0.49 6.66 0.34 1.17e-10 Thyroid stimulating hormone; CRC cis rs1003719 0.788 rs2835600 chr21:38468958 A/G cg10648535 chr21:38446584 PIGP;TTC3 0.52 7.41 0.38 1.07e-12 Eye color traits; CRC cis rs5753037 0.585 rs249396 chr22:30213972 T/G cg01021169 chr22:30184971 ASCC2 -0.44 -6.95 -0.36 1.97e-11 Type 1 diabetes; CRC cis rs3749237 1.000 rs3749237 chr3:49770032 C/T cg03060546 chr3:49711283 APEH 0.5 7.52 0.38 5.43e-13 Resting heart rate; CRC cis rs9303280 0.806 rs11870965 chr17:38030205 T/A cg00129232 chr17:37814104 STARD3 -0.45 -7.16 -0.37 5.33e-12 Self-reported allergy; CRC cis rs912057 1.000 rs1294410 chr6:6738752 C/T cg06612196 chr6:6737390 NA -0.55 -8.74 -0.43 1.22e-16 Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg20538819 chr1:214724805 PTPN14 0.43 6.11 0.32 2.81e-9 Response to antipsychotic treatment; CRC cis rs57221529 0.655 rs11948381 chr5:568413 A/T cg14541582 chr5:601475 NA -0.27 -5.62 -0.3 4e-8 Lung disease severity in cystic fibrosis; CRC trans rs877282 0.898 rs11253343 chr10:765117 C/T cg22713356 chr15:30763199 NA 1.29 15.31 0.65 2.44e-40 Uric acid levels; CRC cis rs6558530 1.000 rs6558530 chr8:1706207 A/G cg19131313 chr8:1704013 NA -0.45 -5.9 -0.31 8.88e-9 Systolic blood pressure; CRC trans rs9929218 0.954 rs60302411 chr16:68824220 A/C cg04657470 chr2:198365150 HSPE1;HSPD1 -0.77 -11.19 -0.53 7.43e-25 Colorectal cancer; CRC cis rs929354 0.739 rs1182439 chr7:157027367 G/A cg05182265 chr7:156933206 UBE3C 0.76 14.57 0.63 1.95e-37 Body mass index; CRC cis rs294883 0.739 rs1504254 chr6:159731223 A/G cg14500486 chr6:159655392 FNDC1 -0.36 -6.18 -0.32 1.92e-9 Coronary artery disease; CRC cis rs73200209 0.744 rs17498893 chr12:116674831 G/C cg01776926 chr12:116560359 MED13L -0.6 -6.94 -0.36 2.12e-11 Total body bone mineral density; CRC cis rs6543140 0.964 rs2310301 chr2:103072935 C/T cg09003973 chr2:102972529 NA 0.41 5.83 0.31 1.33e-8 Blood protein levels; CRC cis rs1046896 0.514 rs9894705 chr17:80823758 A/C cg16060761 chr17:80687452 NA 0.43 5.67 0.3 3.21e-8 Glycated hemoglobin levels; CRC cis rs2303759 0.709 rs10422677 chr19:49824290 C/T cg22590775 chr19:49891494 CCDC155 0.59 7.77 0.39 9.86e-14 Multiple sclerosis; CRC cis rs4713118 0.586 rs6905522 chr6:28086479 A/C cg03623178 chr6:28175578 NA 0.95 12.17 0.56 2.13e-28 Parkinson's disease; CRC cis rs7618915 0.508 rs12498066 chr3:52627660 G/A cg07507251 chr3:52567010 NT5DC2 0.42 5.98 0.31 5.82e-9 Bipolar disorder; CRC cis rs4253772 0.591 rs6008545 chr22:46686375 C/T cg03482458 chr22:46692211 CN5H6.4;GTSE1 0.56 7.87 0.4 5.2e-14 LDL cholesterol;Cholesterol, total; CRC cis rs13118159 0.509 rs4974556 chr4:1358141 G/C cg19318889 chr4:1322082 MAEA 0.71 10.45 0.5 2.9e-22 Longevity; CRC cis rs1348850 0.609 rs1348851 chr2:178418677 C/T cg27490568 chr2:178487706 NA -0.6 -7.08 -0.36 8.59e-12 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs17209837 1.000 rs2302386 chr7:87091944 A/G cg00919237 chr7:87102261 ABCB4 -0.47 -5.63 -0.3 3.84e-8 Gallbladder cancer; CRC cis rs7937682 1.000 rs7121011 chr11:111568681 C/T cg09085632 chr11:111637200 PPP2R1B 1.03 19.18 0.73 1.45e-55 Primary sclerosing cholangitis; CRC cis rs2204008 0.521 rs7311188 chr12:38542813 C/G cg26384229 chr12:38710491 ALG10B -0.52 -7.61 -0.39 2.96e-13 Bladder cancer; CRC cis rs1949733 0.816 rs2631746 chr4:8490934 C/T cg11789530 chr4:8429930 ACOX3 -0.73 -11.44 -0.53 9.73e-26 Response to antineoplastic agents; CRC cis rs7216064 1.000 rs4271626 chr17:65930133 G/A cg12091567 chr17:66097778 LOC651250 -0.61 -7.18 -0.37 4.74e-12 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CRC trans rs3960554 0.808 rs2302434 chr7:75630183 C/T cg19862616 chr7:65841803 NCRNA00174 0.71 8.44 0.42 1.03e-15 Eotaxin levels; CRC cis rs2404602 0.692 rs2120108 chr15:76869929 G/T cg03037974 chr15:76606532 NA -0.69 -11.54 -0.54 4.27e-26 Blood metabolite levels; CRC cis rs853679 1.000 rs10456362 chr6:28221816 A/G cg03623178 chr6:28175578 NA -0.67 -7.18 -0.37 4.56e-12 Depression; CRC cis rs911119 0.955 rs6048945 chr20:23602228 C/T cg16589663 chr20:23618590 CST3 0.47 6.5 0.34 2.92e-10 Chronic kidney disease; CRC cis rs8060686 0.641 rs8059305 chr16:68036666 A/C cg26727032 chr16:67993705 SLC12A4 -0.59 -8.13 -0.41 8.93e-15 HDL cholesterol;Metabolic syndrome; CRC cis rs9309711 0.544 rs9752130 chr2:3488502 A/G cg10845886 chr2:3471009 TTC15 -0.41 -6.31 -0.33 9.18e-10 Neurofibrillary tangles; CRC cis rs17641971 0.599 rs818555 chr8:49999211 A/G cg00325661 chr8:49890786 NA -0.44 -7.75 -0.39 1.16e-13 Blood metabolite levels; CRC cis rs11792861 0.962 rs3829084 chr9:111801724 C/G cg05043794 chr9:111880884 C9orf5 0.34 6.3 0.33 9.71e-10 Menarche (age at onset); CRC cis rs2223471 1.000 rs6928000 chr6:50742161 G/A cg03432817 chr6:50765336 NA 0.4 6.36 0.33 6.7e-10 Subcutaneous adipose tissue; CRC cis rs4713118 0.824 rs742046 chr6:27739254 A/G cg12273811 chr6:28175739 NA 0.47 6.2 0.32 1.64e-9 Parkinson's disease; CRC cis rs400736 0.860 rs371452 chr1:8084051 C/T cg25007680 chr1:8021821 PARK7 0.52 7.26 0.37 2.82e-12 Response to antidepressants and depression; CRC cis rs2303759 0.918 rs1054770 chr19:49878115 G/A cg22307029 chr19:49891270 CCDC155 0.68 9.72 0.47 8.52e-20 Multiple sclerosis; CRC cis rs1005277 0.579 rs2504148 chr10:38400788 A/G cg00409905 chr10:38381863 ZNF37A -0.68 -11.35 -0.53 2.04e-25 Extrinsic epigenetic age acceleration; CRC cis rs6860806 0.507 rs273901 chr5:131694360 G/T cg20512303 chr5:131592959 PDLIM4 0.38 6.56 0.34 2.09e-10 Breast cancer; CRC cis rs2072499 0.966 rs2842869 chr1:156160696 A/G cg06970220 chr1:156163860 SLC25A44 0.5 7.13 0.37 6.42e-12 Testicular germ cell tumor; CRC trans rs7615952 0.512 rs11929125 chr3:125359443 G/A cg02007433 chr3:129722099 NA -0.61 -9.23 -0.45 3.33e-18 Blood pressure (smoking interaction); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg10424846 chr17:33894970 NA 0.39 6.62 0.34 1.46e-10 Liver disease severity in Alagille syndrome; CRC cis rs6963495 0.818 rs115609508 chr7:105163716 C/A cg13798780 chr7:105162888 PUS7 0.68 8.08 0.41 1.27e-14 Bipolar disorder (body mass index interaction); CRC cis rs7727544 0.654 rs4705849 chr5:131559199 T/A cg22638593 chr5:131593259 PDLIM4 0.36 6.56 0.34 2.12e-10 Blood metabolite levels; CRC cis rs344364 0.511 rs1657134 chr16:1953127 A/G cg09830162 chr16:1889614 FAHD1;C16orf73 -0.74 -9.17 -0.45 5.38e-18 Glomerular filtration rate in chronic kidney disease; CRC cis rs12410462 0.681 rs115959512 chr1:227599578 T/C cg23173402 chr1:227635558 NA 0.8 7.03 0.36 1.23e-11 Major depressive disorder; CRC trans rs10242455 1.000 rs28468623 chr7:98922812 C/G cg09045935 chr12:6379348 NA 0.72 6.68 0.35 1.03e-10 Blood metabolite levels; CRC cis rs13118159 0.872 rs1882105 chr4:1345956 T/C cg21620606 chr4:1342894 KIAA1530 0.5 8.56 0.43 4.31e-16 Longevity; CRC cis rs9868809 0.881 rs13076269 chr3:48675925 T/C cg00383909 chr3:49044727 WDR6 0.67 6.8 0.35 4.91e-11 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; CRC cis rs4974559 0.690 rs28515563 chr4:1315123 G/A cg02980000 chr4:1222292 CTBP1 0.72 7.95 0.4 2.93e-14 Systolic blood pressure; CRC cis rs9911578 1.000 rs6503870 chr17:56659018 C/T cg12560992 chr17:57184187 TRIM37 0.91 16.85 0.68 2.2e-46 Intelligence (multi-trait analysis); CRC cis rs6570726 0.905 rs377143 chr6:145834220 C/T cg23711669 chr6:146136114 FBXO30 0.63 10.81 0.51 1.66e-23 Lobe attachment (rater-scored or self-reported); CRC cis rs2404602 0.647 rs8025991 chr15:77155268 C/T cg03037974 chr15:76606532 NA -0.54 -8.07 -0.41 1.31e-14 Blood metabolite levels; CRC cis rs12586317 0.547 rs60152856 chr14:35421373 G/A cg05294307 chr14:35346193 BAZ1A -0.7 -7.7 -0.39 1.6e-13 Psoriasis; CRC cis rs11098499 0.754 rs9991959 chr4:120253773 C/T cg24375607 chr4:120327624 NA -0.47 -7.59 -0.39 3.42e-13 Corneal astigmatism; CRC cis rs2836974 0.605 rs2836988 chr21:40707975 A/G cg11890956 chr21:40555474 PSMG1 -0.83 -13.32 -0.59 1.12e-32 Cognitive function; CRC cis rs919433 0.783 rs788011 chr2:198230771 A/G cg03934865 chr2:198174659 NA 0.36 5.81 0.31 1.44e-8 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC cis rs9910055 0.529 rs615070 chr17:42176591 A/G cg19774624 chr17:42201019 HDAC5 -0.46 -6.31 -0.33 9.06e-10 Total body bone mineral density; CRC cis rs9372498 0.505 rs9481789 chr6:118734320 A/C cg18833306 chr6:118973337 C6orf204 0.44 5.81 0.31 1.48e-8 Diastolic blood pressure; CRC cis rs9925964 0.933 rs2303222 chr16:31085470 A/G cg02466173 chr16:30829666 NA 0.42 5.88 0.31 1e-8 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs709400 0.930 rs61996717 chr14:104048571 T/C cg12935359 chr14:103987150 CKB -0.37 -5.8 -0.3 1.58e-8 Body mass index; CRC cis rs763121 0.853 rs3747170 chr22:39067331 G/A cg06544989 chr22:39130855 UNC84B 0.46 7.11 0.36 7.48e-12 Menopause (age at onset); CRC cis rs35110281 0.720 rs162392 chr21:44941406 A/G cg04455712 chr21:45112962 RRP1B 0.43 8.26 0.41 3.59e-15 Mean corpuscular volume; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg14347670 chr6:41908995 CCND3 0.45 6.3 0.33 9.53e-10 Response to antipsychotic treatment; CRC cis rs2228479 0.702 rs62053701 chr16:89860584 G/A cg06558623 chr16:89946397 TCF25 1.18 11.57 0.54 3.24e-26 Skin colour saturation; CRC cis rs9291683 0.552 rs10939656 chr4:10014646 A/C cg00071950 chr4:10020882 SLC2A9 0.67 12.89 0.58 4.84e-31 Bone mineral density; CRC cis rs13253111 0.624 rs28372101 chr8:28099384 G/T cg26534493 chr8:28060551 NA 0.41 7.17 0.37 4.87e-12 Childhood body mass index; CRC cis rs826838 0.935 rs3886109 chr12:39189243 C/T cg26384229 chr12:38710491 ALG10B 0.69 9.33 0.46 1.61e-18 Heart rate; CRC trans rs916888 0.773 rs199451 chr17:44801784 G/A cg01341218 chr17:43662625 NA 0.97 10.37 0.5 5.57e-22 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC trans rs2303319 0.504 rs2175142 chr2:162450124 T/C cg18122310 chr12:50236657 BCDIN3D -0.72 -6.17 -0.32 2.06e-9 Cognitive function; CRC cis rs1448094 0.836 rs6539935 chr12:86376809 T/C cg19622623 chr12:86230825 RASSF9 -0.36 -5.77 -0.3 1.82e-8 Major depressive disorder; CRC cis rs17711722 0.640 rs13237956 chr7:65318029 G/A cg18876405 chr7:65276391 NA 0.64 11.85 0.55 3.23e-27 Calcium levels; CRC cis rs853679 0.517 rs7755442 chr6:28039015 T/C cg02631126 chr6:28058918 ZSCAN12L1 0.29 6.1 0.32 2.93e-9 Depression; CRC cis rs1799949 0.930 rs1554063 chr17:41287145 T/C cg25072359 chr17:41440525 NA 0.52 8.35 0.42 1.96e-15 Menopause (age at onset); CRC cis rs3820928 1.000 rs11686072 chr2:227777493 A/T cg11843606 chr2:227700838 RHBDD1 -0.41 -5.98 -0.31 5.91e-9 Pulmonary function; CRC cis rs599083 0.530 rs576118 chr11:68177708 C/T cg01657329 chr11:68192670 LRP5 0.5 7.18 0.37 4.79e-12 Bone mineral density (spine); CRC cis rs13108904 0.875 rs10024013 chr4:1280792 C/T cg02018176 chr4:1364513 KIAA1530 -0.46 -7.8 -0.4 8.03e-14 Obesity-related traits; CRC cis rs7552404 0.731 rs61770556 chr1:76421902 T/C cg03433033 chr1:76189801 ACADM 0.71 8.11 0.41 1.04e-14 Blood metabolite levels;Acylcarnitine levels; CRC trans rs3733585 0.637 rs6850684 chr4:9964380 G/T cg26043149 chr18:55253948 FECH -0.5 -7.62 -0.39 2.7e-13 Cleft plate (environmental tobacco smoke interaction); CRC cis rs7659604 0.539 rs11098646 chr4:122729301 T/C cg23574427 chr4:122746245 BBS7;CCNA2 -0.3 -5.65 -0.3 3.39e-8 Type 2 diabetes; CRC cis rs951366 0.617 rs708727 chr1:205767885 G/A cg26354017 chr1:205819088 PM20D1 0.93 15.88 0.66 1.43e-42 Menarche (age at onset); CRC cis rs9916302 0.904 rs11655531 chr17:37697959 T/C cg07936489 chr17:37558343 FBXL20 -0.81 -12.41 -0.56 2.83e-29 Glomerular filtration rate (creatinine); CRC cis rs9768139 0.733 rs13221388 chr7:158119270 G/A cg06219351 chr7:158114137 PTPRN2 -0.55 -8.34 -0.42 2.11e-15 Calcium levels; CRC cis rs10504073 0.584 rs10957337 chr8:49959027 G/T cg00325661 chr8:49890786 NA 0.6 10.73 0.51 3.14e-23 Blood metabolite ratios; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg18652121 chr3:179322868 MRPL47;NDUFB5 0.43 6.11 0.32 2.88e-9 Response to antipsychotic treatment; CRC trans rs2303319 0.504 rs62189046 chr2:162612371 C/G cg23247704 chr1:116518985 SLC22A15 -0.72 -6.14 -0.32 2.42e-9 Cognitive function; CRC cis rs7811142 1.000 rs11771241 chr7:99994785 G/A cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.16 16.58 0.67 2.55e-45 Platelet count; CRC trans rs1997103 0.822 rs10273426 chr7:55417857 G/A cg20935933 chr6:143382018 AIG1 0.51 6.48 0.34 3.34e-10 QRS interval (sulfonylurea treatment interaction); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg14045725 chr17:2240967 SGSM2;TSR1 0.41 6.29 0.33 1.02e-9 Intelligence (multi-trait analysis); CRC cis rs6952808 0.656 rs73048919 chr7:2103637 C/A cg00106254 chr7:1943704 MAD1L1 -0.42 -5.76 -0.3 1.9e-8 Bipolar disorder and schizophrenia; CRC cis rs9326248 0.954 rs521171 chr11:117064693 C/G cg15534755 chr11:117069859 TAGLN 0.34 6.46 0.34 3.84e-10 Blood protein levels; CRC cis rs4665809 0.590 rs66477033 chr2:26472497 T/C cg27170947 chr2:26402098 FAM59B 0.6 7.82 0.4 7.45e-14 Gut microbiome composition (summer); CRC cis rs17384381 0.636 rs11161615 chr1:85906816 A/G cg16011679 chr1:85725395 C1orf52 -0.5 -6.24 -0.33 1.37e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs1799949 1.000 rs2298862 chr17:41176688 T/C cg23758822 chr17:41437982 NA 0.8 13.22 0.59 2.77e-32 Menopause (age at onset); CRC cis rs853679 0.517 rs6932109 chr6:28078303 A/G cg23161317 chr6:28129485 ZNF389 -0.45 -5.75 -0.3 1.99e-8 Depression; CRC cis rs61774743 0.521 rs60144015 chr1:41845246 C/A cg08144172 chr1:41849203 NA 0.35 5.83 0.31 1.29e-8 Intelligence (multi-trait analysis); CRC cis rs13118159 0.550 rs28522910 chr4:1374774 C/T cg19318889 chr4:1322082 MAEA 0.65 9.69 0.47 1.04e-19 Longevity; CRC cis rs7615952 0.599 rs6779141 chr3:125709995 A/T cg02807482 chr3:125708958 NA -0.47 -5.96 -0.31 6.39e-9 Blood pressure (smoking interaction); CRC trans rs9693857 0.520 rs10107887 chr8:9364664 T/C cg06636001 chr8:8085503 FLJ10661 0.48 6.27 0.33 1.15e-9 Systolic blood pressure; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg20586607 chr14:50235780 KLHDC2 0.45 6.63 0.34 1.35e-10 Response to antipsychotic treatment; CRC cis rs4722166 0.630 rs12700390 chr7:22777129 G/T cg05472934 chr7:22766657 IL6 0.76 12.37 0.56 4.12e-29 Lung cancer; CRC cis rs9522267 0.535 rs9515452 chr13:112234553 A/G cg26182253 chr13:112236782 NA 0.31 6.3 0.33 9.74e-10 Hepatitis; CRC cis rs9368481 0.700 rs6911401 chr6:26913214 C/G cg12292205 chr6:26970375 C6orf41 0.66 10.89 0.51 8.49e-24 Autism spectrum disorder or schizophrenia; CRC cis rs910316 0.967 rs4899545 chr14:75568138 A/G cg03030879 chr14:75389066 RPS6KL1 -0.47 -7.46 -0.38 7.78e-13 Height; CRC cis rs4731207 0.698 rs4728009 chr7:124470961 A/C cg23710748 chr7:124431027 NA -0.38 -6.22 -0.32 1.48e-9 Cutaneous malignant melanoma; CRC cis rs2668423 0.922 rs266805 chr19:1376723 C/T cg02639931 chr19:1387894 NDUFS7 -0.63 -9.64 -0.47 1.59e-19 Nonalcoholic fatty liver disease; CRC cis rs2976388 1.000 rs2920295 chr8:143764937 A/G cg15511327 chr8:143859410 LYNX1 -0.33 -5.79 -0.3 1.66e-8 Urinary tract infection frequency; CRC cis rs60843830 0.964 rs17713568 chr2:242132 G/A cg00108164 chr2:264199 ACP1;SH3YL1 0.64 10.11 0.49 4.12e-21 Spherical equivalent (joint analysis main effects and education interaction); CRC cis rs3741151 1.000 rs112628073 chr11:73013626 C/T cg17517138 chr11:73019481 ARHGEF17 1.12 9.97 0.48 1.26e-20 GIP levels in response to oral glucose tolerance test (120 minutes); CRC cis rs7726839 0.540 rs58599998 chr5:596087 A/G cg17948913 chr5:572064 NA 0.5 5.79 0.3 1.61e-8 Obesity-related traits; CRC cis rs4555082 0.830 rs2255575 chr14:105727251 T/C cg18132624 chr14:105716052 BTBD6;BRF1 -0.46 -7.37 -0.38 1.44e-12 Mean platelet volume;Platelet distribution width; CRC cis rs41271473 0.519 rs9660783 chr1:228886880 C/T cg00850481 chr1:228891306 NA -0.39 -5.79 -0.3 1.65e-8 Chronic lymphocytic leukemia; CRC cis rs3793683 0.928 rs10781585 chr10:134553369 C/A cg26818010 chr10:134567672 INPP5A 0.43 7.04 0.36 1.16e-11 Migraine; CRC cis rs7258465 0.931 rs271629 chr19:18623198 G/A cg01065977 chr19:18549689 ISYNA1 -0.39 -6.14 -0.32 2.35e-9 Breast cancer; CRC cis rs10256972 0.758 rs7799391 chr7:1082566 C/G cg22907277 chr7:1156413 C7orf50 0.49 7.33 0.37 1.84e-12 Longevity;Endometriosis; CRC cis rs6741819 1.000 rs13398488 chr2:7142199 A/G cg27144453 chr2:7172511 RNF144A -0.42 -6.15 -0.32 2.26e-9 Response to antipsychotic treatment; CRC cis rs2836974 0.897 rs8132295 chr21:40527774 A/G cg17971929 chr21:40555470 PSMG1 -0.83 -12.68 -0.57 2.92e-30 Cognitive function; CRC cis rs765787 0.530 rs2413780 chr15:45538866 A/G cg24006582 chr15:45444508 DUOX1 -0.57 -8.63 -0.43 2.62e-16 Uric acid levels; CRC trans rs1656966 1.000 rs1656966 chr3:186466252 C/T cg25652642 chr19:10514370 MIR1181;CDC37 0.41 6.32 0.33 8.66e-10 Myopia (pathological); CRC cis rs9925964 0.933 rs2303223 chr16:31075175 G/A cg03418659 chr16:31128414 MYST1 0.47 6.72 0.35 7.9e-11 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs4604732 0.603 rs4546958 chr1:247639478 G/C cg02104434 chr1:247694406 LOC148824;OR2C3 0.42 6.73 0.35 7.71e-11 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CRC cis rs2645694 0.626 rs2703136 chr4:77828957 T/A cg10057126 chr4:77819792 ANKRD56 0.34 5.71 0.3 2.58e-8 Emphysema distribution in smoking; CRC cis rs6951245 0.872 rs11768486 chr7:1101290 C/A cg24642844 chr7:1081250 C7orf50 -0.76 -9.16 -0.45 5.78e-18 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs1953600 0.818 rs2152546 chr10:81906384 G/T cg04850286 chr10:81895943 PLAC9 -0.38 -7.01 -0.36 1.36e-11 Sarcoidosis; CRC cis rs2836974 1.000 rs12710454 chr21:40656919 A/G cg07074390 chr21:40555500 PSMG1 -0.45 -6.14 -0.32 2.44e-9 Cognitive function; CRC cis rs66573146 0.831 rs56031152 chr4:6973832 C/A cg00086871 chr4:6988644 TBC1D14 1.02 8.46 0.42 9.13e-16 Granulocyte percentage of myeloid white cells; CRC cis rs513349 1.000 rs513349 chr6:33541719 A/G cg24505687 chr6:33548425 BAK1 0.3 5.79 0.3 1.66e-8 Platelet count; CRC cis rs9322193 0.923 rs12176034 chr6:150121693 C/T cg04369109 chr6:150039330 LATS1 -0.47 -6.12 -0.32 2.68e-9 Lung cancer; CRC cis rs7107770 0.663 rs1078532 chr11:125073484 G/A cg27629782 chr11:125073726 PKNOX2 0.51 7.31 0.37 2.05e-12 Photic sneeze reflex; CRC cis rs7833790 0.636 rs12544174 chr8:82731477 G/A cg17211192 chr8:82754475 SNX16 -0.47 -6.61 -0.34 1.59e-10 Diastolic blood pressure; CRC cis rs863345 0.547 rs10908675 chr1:158504129 A/C cg12129480 chr1:158549410 OR10X1 -0.3 -6.27 -0.33 1.12e-9 Pneumococcal bacteremia; CRC cis rs1552244 0.935 rs2272124 chr3:10138189 T/C cg02579736 chr3:10068473 FANCD2;CIDECP 0.92 12.54 0.57 9.29e-30 Alzheimer's disease; CRC cis rs798554 1.000 rs798554 chr7:2759795 C/T cg14895029 chr7:2775587 GNA12 -0.4 -5.93 -0.31 7.5e-9 Height; CRC cis rs9640161 0.711 rs60268791 chr7:150023800 G/T cg13722127 chr7:150037890 RARRES2 0.48 8.03 0.4 1.77e-14 Blood protein levels;Circulating chemerin levels; CRC cis rs6499255 0.857 rs8060588 chr16:69656500 A/G cg04110750 chr16:69646130 NFAT5 -0.56 -7.62 -0.39 2.73e-13 IgE levels; CRC cis rs7705042 0.865 rs12656877 chr5:141490091 T/C cg08523384 chr5:141488047 NDFIP1 -0.33 -5.78 -0.3 1.71e-8 Asthma; CRC cis rs372883 0.648 rs368322 chr21:30717151 C/T cg24692254 chr21:30365293 RNF160 -0.61 -9.36 -0.46 1.25e-18 Pancreatic cancer; CRC cis rs6088580 0.634 rs4911422 chr20:32999345 T/C cg08999081 chr20:33150536 PIGU -0.61 -11.54 -0.54 4.11e-26 Glomerular filtration rate (creatinine); CRC cis rs10751667 0.666 rs7936830 chr11:959686 A/G ch.11.42038R chr11:967971 AP2A2 0.58 10.11 0.49 4.24e-21 Alzheimer's disease (late onset); CRC cis rs62244186 0.714 rs2293600 chr3:44599103 G/T cg11003573 chr3:44754125 ZNF502 0.35 5.94 0.31 7.09e-9 Depressive symptoms; CRC cis rs8077889 0.956 rs4793025 chr17:41841621 T/C cg25876840 chr17:41920477 NA 0.53 7.23 0.37 3.44e-12 Triglycerides; CRC cis rs71403859 0.504 rs35203704 chr16:71959661 G/A cg08717414 chr16:71523259 ZNF19 -0.83 -7.11 -0.37 7.17e-12 Post bronchodilator FEV1; CRC cis rs3741404 0.560 rs7938819 chr11:63910116 G/A cg15107132 chr11:63991130 FERMT3 0.38 6.2 0.32 1.73e-9 Platelet count; CRC cis rs375066 0.623 rs239948 chr19:44356887 A/T cg19542119 chr19:44331823 ZNF283 -0.41 -5.88 -0.31 1.02e-8 Breast cancer; CRC cis rs9487051 0.768 rs445796 chr6:109520145 T/C cg21918786 chr6:109611834 NA -0.33 -5.73 -0.3 2.3e-8 Reticulocyte fraction of red cells; CRC trans rs1908814 0.516 rs13281077 chr8:11794814 C/T cg06636001 chr8:8085503 FLJ10661 0.48 7.03 0.36 1.17e-11 Neuroticism; CRC cis rs11212617 0.967 rs11605442 chr11:108077857 G/A cg12106634 chr11:108092400 ATM;NPAT 0.42 6.27 0.33 1.14e-9 Response to metformin in type 2 diabetes (glycemic); CRC cis rs9325144 0.532 rs12812406 chr12:38719802 G/A cg13010199 chr12:38710504 ALG10B -0.43 -6.09 -0.32 3.2e-9 Morning vs. evening chronotype; CRC cis rs1018836 0.851 rs7014073 chr8:91618548 T/C cg16814680 chr8:91681699 NA -0.77 -12.25 -0.56 1.16e-28 Ejection fraction in Tripanosoma cruzi seropositivity; CRC cis rs2811415 0.597 rs9844891 chr3:127743260 C/T cg13719885 chr3:127795394 NA -0.36 -5.62 -0.3 4.1e-8 Lung function (FEV1/FVC); CRC cis rs1465370 0.682 rs2268382 chr7:130027037 A/C cg03229158 chr7:130009420 NA 0.42 5.93 0.31 7.86e-9 Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction);Waist circumference adjusted for BMI in active individuals;Waist circumference adjusted for body mass index; CRC cis rs929354 0.742 rs62491945 chr7:156955580 G/A cg05182265 chr7:156933206 UBE3C -0.76 -14.38 -0.62 1.04e-36 Body mass index; CRC trans rs7395662 0.963 rs1857786 chr11:48967424 G/A cg21153622 chr11:89784906 NA -0.48 -7.62 -0.39 2.78e-13 HDL cholesterol; CRC cis rs644799 1.000 rs11021319 chr11:95523123 C/G cg25622487 chr11:95524042 FAM76B;CEP57 0.76 11.89 0.55 2.32e-27 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs62229266 0.804 rs62230788 chr21:37380337 A/T cg08632701 chr21:37451849 NA -0.41 -6.16 -0.32 2.17e-9 Mitral valve prolapse; CRC cis rs4819052 0.788 rs4819051 chr21:46693128 C/T cg19498844 chr21:46707878 POFUT2;LOC642852 0.79 11.53 0.54 4.72e-26 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs1552244 0.882 rs17050660 chr3:10001772 A/G cg10729496 chr3:10149963 C3orf24 -0.49 -6.54 -0.34 2.37e-10 Alzheimer's disease; CRC cis rs78472555 0.954 rs2123926 chr15:100264518 T/C cg18869061 chr15:100272053 LYSMD4 -0.55 -6.66 -0.34 1.18e-10 Post bronchodilator FEV1/FVC ratio in COPD; CRC cis rs2836974 0.897 rs8132568 chr21:40527916 C/T cg11890956 chr21:40555474 PSMG1 1.1 21.19 0.76 1.86e-63 Cognitive function; CRC cis rs4731207 0.535 rs11769711 chr7:124574924 A/T cg23710748 chr7:124431027 NA -0.39 -6.19 -0.32 1.8e-9 Cutaneous malignant melanoma; CRC cis rs4972806 0.814 rs4246626 chr2:177046430 A/C cg03152288 chr2:177042942 NA 0.81 13.15 0.59 4.97e-32 IgG glycosylation; CRC cis rs2742417 1.000 rs2742417 chr3:45731451 C/T cg04837898 chr3:45731254 SACM1L -0.36 -5.9 -0.31 9.08e-9 Response to anti-depressant treatment in major depressive disorder; CRC cis rs2408955 0.522 rs11168408 chr12:48498327 G/A cg00601486 chr12:48723148 H1FNT -0.35 -6.55 -0.34 2.2e-10 Glycated hemoglobin levels; CRC cis rs9291683 0.530 rs11723970 chr4:9980462 T/C cg11266682 chr4:10021025 SLC2A9 0.5 10.34 0.5 6.86e-22 Bone mineral density; CRC cis rs6545883 0.831 rs9309336 chr2:61763165 T/C cg15711740 chr2:61764176 XPO1 -0.53 -7.3 -0.37 2.22e-12 Tuberculosis; CRC cis rs9549260 0.709 rs12585870 chr13:41199487 A/C cg21288729 chr13:41239152 FOXO1 0.43 6.85 0.35 3.7e-11 Red blood cell count; CRC cis rs3820068 0.580 rs12747696 chr1:16002978 A/G cg24675056 chr1:15929824 NA 0.52 7.18 0.37 4.69e-12 Systolic blood pressure; CRC cis rs7131987 0.903 rs6487796 chr12:29422764 A/G cg09582351 chr12:29534625 ERGIC2 -0.33 -7.11 -0.36 7.38e-12 QT interval; CRC cis rs881375 1.000 rs6478484 chr9:123652380 T/C cg09419670 chr9:123605666 PSMD5;LOC253039 0.59 8.69 0.43 1.79e-16 Rheumatoid arthritis; CRC cis rs1862618 0.620 rs2591967 chr5:56233551 C/G cg18230493 chr5:56204884 C5orf35 0.6 8.71 0.43 1.5e-16 Initial pursuit acceleration; CRC cis rs561341 1.000 rs1557731 chr17:30321567 T/G cg00745463 chr17:30367425 LRRC37B -0.7 -8.43 -0.42 1.1e-15 Hip circumference adjusted for BMI; CRC cis rs6570726 0.902 rs406979 chr6:145838983 G/T cg13319975 chr6:146136371 FBXO30 -0.38 -5.8 -0.3 1.53e-8 Lobe attachment (rater-scored or self-reported); CRC cis rs7917772 0.636 rs7897384 chr10:104529042 T/G cg22532475 chr10:104410764 TRIM8 0.34 5.8 0.3 1.58e-8 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC cis rs17065868 0.764 rs61949794 chr13:45030109 A/G cg10246903 chr13:45222710 NA 0.54 5.69 0.3 2.79e-8 Antineutrophil cytoplasmic antibody-associated vasculitis; CRC cis rs9818758 0.607 rs5030795 chr3:49141116 C/T cg00383909 chr3:49044727 WDR6 1.06 10.58 0.5 1.08e-22 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; CRC cis rs9341808 0.718 rs2322631 chr6:80843956 A/C cg08355045 chr6:80787529 NA 0.42 6.86 0.35 3.38e-11 Sitting height ratio; CRC cis rs4988958 0.525 rs3771159 chr2:103004958 T/C cg03938978 chr2:103052716 IL18RAP 0.59 10.18 0.49 2.53e-21 Asthma (childhood onset); CRC cis rs10504229 1.000 rs73609747 chr8:58189104 G/C cg24829409 chr8:58192753 C8orf71 -0.68 -11.34 -0.53 2.27e-25 Developmental language disorder (linguistic errors); CRC cis rs4988958 0.527 rs3771155 chr2:103037826 A/G cg03938978 chr2:103052716 IL18RAP 0.59 10.13 0.49 3.5e-21 Asthma (childhood onset); CRC cis rs2050392 0.965 rs2480279 chr10:30700032 C/T cg25182066 chr10:30743637 MAP3K8 -0.39 -5.78 -0.3 1.73e-8 Inflammatory bowel disease; CRC trans rs634534 0.622 rs531612 chr11:65705432 C/T cg17712092 chr4:129076599 LARP1B -0.64 -10.14 -0.49 3.28e-21 Sum eosinophil basophil counts;Eosinophil counts; CRC cis rs4073416 0.542 rs12433597 chr14:66028847 T/C cg03016385 chr14:66212404 NA -0.45 -6.25 -0.33 1.24e-9 N-glycan levels; CRC cis rs12497850 0.764 rs6784111 chr3:49178846 T/C cg20833759 chr3:49053208 WDR6;DALRD3 0.45 7.29 0.37 2.32e-12 Parkinson's disease; CRC cis rs2952156 0.959 rs1495101 chr17:37832103 C/A cg20243544 chr17:37824526 PNMT 0.55 8.43 0.42 1.08e-15 Asthma; CRC cis rs12762955 0.687 rs4880470 chr10:1077480 G/A cg18964960 chr10:1102726 WDR37 -0.44 -6.25 -0.33 1.27e-9 Response to angiotensin II receptor blocker therapy; CRC cis rs853679 0.517 rs17711344 chr6:28077602 A/G cg25164649 chr6:28176230 NA -0.74 -9.2 -0.45 4.39e-18 Depression; CRC cis rs11971779 0.625 rs10260850 chr7:139003602 G/T cg07862535 chr7:139043722 LUC7L2 0.54 6.82 0.35 4.41e-11 Diisocyanate-induced asthma; CRC cis rs2411233 1.000 rs7168645 chr15:39271165 C/T cg23129342 chr15:39283510 NA 0.31 5.65 0.3 3.48e-8 Platelet count; CRC cis rs10242455 0.557 rs59672032 chr7:99058697 T/C cg18809830 chr7:99032528 PTCD1 -0.87 -6.84 -0.35 3.98e-11 Blood metabolite levels; CRC cis rs6502050 0.871 rs8066970 chr17:80076051 T/C cg22110888 chr17:80059540 CCDC57 -0.43 -6.69 -0.35 9.49e-11 Life satisfaction; CRC trans rs7937682 1.000 rs11213973 chr11:111538903 A/T cg18187862 chr3:45730750 SACM1L 0.47 6.85 0.35 3.65e-11 Primary sclerosing cholangitis; CRC cis rs34375054 0.526 rs2343638 chr12:125677122 G/C cg25124228 chr12:125621409 AACS -0.57 -8.11 -0.41 1.03e-14 Post bronchodilator FEV1/FVC ratio; CRC cis rs8014671 0.553 rs11628785 chr14:70908217 G/A cg25576086 chr14:70833871 SYNJ2BP -0.35 -5.87 -0.31 1.05e-8 Prostate cancer; CRC cis rs7618915 0.571 rs2289249 chr3:52597664 G/A cg08222913 chr3:52553049 STAB1 -0.34 -6.27 -0.33 1.14e-9 Bipolar disorder; CRC cis rs11677416 1.000 rs72825514 chr2:113527706 G/T cg27083787 chr2:113543245 IL1A 0.49 6.88 0.35 3.07e-11 Response to antipsychotic treatment in schizophrenia (working memory); CRC cis rs35110281 0.755 rs4819270 chr21:45020919 G/A cg01579765 chr21:45077557 HSF2BP -0.38 -7.28 -0.37 2.53e-12 Mean corpuscular volume; CRC cis rs6762 0.748 rs3059 chr11:840319 C/T cg07691484 chr11:842764 TSPAN4;POLR2L -0.56 -8.29 -0.42 2.99e-15 Mean platelet volume; CRC cis rs10504229 0.683 rs16921810 chr8:58106067 A/G cg02290350 chr8:58132656 NA -0.59 -8.02 -0.4 1.88e-14 Developmental language disorder (linguistic errors); CRC cis rs6694672 0.867 rs10922166 chr1:197080036 G/C cg13682187 chr1:196946512 CFHR5 0.47 7.63 0.39 2.49e-13 Asthma; CRC cis rs1552244 1.000 rs67569278 chr3:10149893 T/C cg18598329 chr3:10140678 FANCD2;C3orf24 -0.88 -11.5 -0.54 5.74e-26 Alzheimer's disease; CRC cis rs1707322 0.752 rs10430105 chr1:46138876 G/A cg06784218 chr1:46089804 CCDC17 0.65 12.18 0.56 2e-28 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs4588572 0.644 rs1159930 chr5:77768943 C/T cg11446398 chr5:77624930 NA -0.41 -5.88 -0.31 1e-8 Triglycerides; CRC cis rs11123170 0.542 rs11123169 chr2:113967075 C/T cg12889195 chr2:113992843 PAX8;LOC440839;LOC654433 -0.48 -6.58 -0.34 1.9e-10 Renal function-related traits (BUN); CRC cis rs769267 0.965 rs4808937 chr19:19398005 A/G cg03709012 chr19:19516395 GATAD2A 0.71 10.97 0.52 4.39e-24 Tonsillectomy; CRC cis rs7223966 1.000 rs1877316 chr17:61766880 C/A cg05941027 chr17:61774174 LIMD2 0.36 6.52 0.34 2.65e-10 Hip circumference adjusted for BMI;Body mass index; CRC cis rs7224737 1.000 rs2240010 chr17:40278081 T/A cg02450064 chr17:40260053 DHX58 -0.43 -6.23 -0.32 1.44e-9 Fibrinogen levels; CRC cis rs524281 0.861 rs7946917 chr11:65956577 A/G cg16950941 chr11:66035639 RAB1B -0.6 -7.43 -0.38 9.29e-13 Electroencephalogram traits; CRC trans rs2727020 0.533 rs10839195 chr11:48973460 C/T cg00717180 chr2:96193071 NA -0.39 -6.47 -0.34 3.53e-10 Coronary artery disease; CRC cis rs853679 0.517 rs3757187 chr6:28107654 T/C cg02631126 chr6:28058918 ZSCAN12L1 0.29 5.89 0.31 9.41e-9 Depression; CRC cis rs10504229 0.683 rs16921823 chr8:58108612 G/C cg02290350 chr8:58132656 NA -0.59 -8.03 -0.4 1.7e-14 Developmental language disorder (linguistic errors); CRC cis rs644799 1.000 rs644799 chr11:95564259 A/G cg03916912 chr11:95522834 CEP57;FAM76B 0.96 18.53 0.71 5.15e-53 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs6662572 0.737 rs6700974 chr1:46371735 C/A cg03123370 chr1:45965343 CCDC163P;MMACHC -0.46 -5.85 -0.31 1.21e-8 Blood protein levels; CRC cis rs7617480 0.616 rs7429596 chr3:48808531 T/C cg20833759 chr3:49053208 WDR6;DALRD3 0.75 11.13 0.52 1.21e-24 Subjective well-being (multi-trait analysis);Menarche (age at onset); CRC cis rs1129187 0.686 rs6458313 chr6:42922018 A/G cg05552183 chr6:42928497 GNMT 0.52 7.85 0.4 5.79e-14 Alzheimer's disease in APOE e4+ carriers; CRC cis rs2404602 0.647 rs10851889 chr15:77023336 C/T cg23625390 chr15:77176239 SCAPER -0.86 -13.84 -0.61 1.22e-34 Blood metabolite levels; CRC cis rs6815814 0.847 rs11725309 chr4:38783848 T/C cg06935464 chr4:38784597 TLR10 0.61 6.28 0.33 1.09e-9 Breast cancer; CRC cis rs938554 0.577 rs7683856 chr4:10000947 A/G cg00071950 chr4:10020882 SLC2A9 0.48 6.66 0.34 1.18e-10 Blood metabolite levels; CRC cis rs10504229 0.636 rs117439064 chr8:58055279 A/G cg02725872 chr8:58115012 NA -0.57 -7.96 -0.4 2.76e-14 Developmental language disorder (linguistic errors); CRC cis rs9858542 0.953 rs1801143 chr3:49570200 C/T cg03060546 chr3:49711283 APEH -0.47 -6.62 -0.34 1.44e-10 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs9859260 0.744 rs539816 chr3:195784076 T/A cg12923728 chr3:195709715 SDHAP1 0.48 6.54 0.34 2.35e-10 Mean corpuscular volume; CRC cis rs4332037 0.624 rs11764124 chr7:1891723 C/G cg23378565 chr7:2036160 MAD1L1 -0.4 -6.14 -0.32 2.32e-9 Bipolar disorder; CRC cis rs10504229 0.683 rs66730544 chr8:58127280 A/T cg02725872 chr8:58115012 NA -0.64 -11.55 -0.54 3.85e-26 Developmental language disorder (linguistic errors); CRC cis rs11997175 0.646 rs12678266 chr8:33689254 A/G ch.8.33884649F chr8:33765107 NA 0.43 6.07 0.32 3.43e-9 Body mass index; CRC cis rs2576037 0.583 rs646128 chr18:44397691 A/C cg19077165 chr18:44547161 KATNAL2 -0.6 -9.68 -0.47 1.15e-19 Personality dimensions; CRC cis rs4713118 0.869 rs9366700 chr6:27696951 C/T cg26587870 chr6:27730563 NA -0.43 -6.72 -0.35 8.04e-11 Parkinson's disease; CRC cis rs9611565 0.659 rs9611604 chr22:41916001 C/G cg03806693 chr22:41940476 POLR3H -1.1 -13.98 -0.61 3.57e-35 Vitiligo; CRC cis rs2425143 0.915 rs2378408 chr20:34367732 T/C cg04508476 chr20:34239394 CPNE1;RBM12 0.48 6.08 0.32 3.36e-9 Blood protein levels; CRC cis rs9486719 1.000 rs9373978 chr6:97056255 T/C cg18709589 chr6:96969512 KIAA0776 -0.5 -5.67 -0.3 3.15e-8 Migraine;Coronary artery disease; CRC cis rs10782582 0.609 rs1159215 chr1:76317869 A/T cg03433033 chr1:76189801 ACADM -0.4 -5.68 -0.3 2.97e-8 Daytime sleep phenotypes; CRC cis rs17065868 0.764 rs9533851 chr13:45015430 A/T cg10246903 chr13:45222710 NA 0.58 5.65 0.3 3.45e-8 Antineutrophil cytoplasmic antibody-associated vasculitis; CRC cis rs11864453 0.826 rs6499560 chr16:72147666 G/T cg01557791 chr16:72042693 DHODH 0.45 6.41 0.33 4.92e-10 Fibrinogen levels; CRC cis rs7811142 0.943 rs67483801 chr7:100031758 G/T cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.14 17.63 0.7 1.96e-49 Platelet count; CRC cis rs2116941 1.000 rs2033493 chr19:10340854 A/C cg01850179 chr19:10340795 S1PR2 -0.79 -11.22 -0.53 5.72e-25 Pulse pressure; CRC trans rs1005277 0.579 rs2983343 chr10:38383332 A/G cg23533926 chr12:111358616 MYL2 -0.52 -7.85 -0.4 6.11e-14 Extrinsic epigenetic age acceleration; CRC cis rs1223397 0.938 rs9381884 chr6:13278788 A/G cg20827128 chr6:13274284 PHACTR1 0.51 6.32 0.33 8.27e-10 Blood pressure; CRC cis rs7618915 0.547 rs3755806 chr3:52643685 C/T cg18404041 chr3:52824283 ITIH1 0.4 8.16 0.41 7.41e-15 Bipolar disorder; CRC trans rs11098499 0.954 rs35091806 chr4:120325529 G/A cg25214090 chr10:38739885 LOC399744 0.66 10.47 0.5 2.41e-22 Corneal astigmatism; CRC cis rs58688157 0.705 rs36060383 chr11:598723 A/C cg07212818 chr11:638076 DRD4 -0.44 -5.78 -0.3 1.73e-8 Systemic lupus erythematosus; CRC cis rs6460942 0.841 rs17444203 chr7:12461864 C/G cg20607287 chr7:12443886 VWDE 0.57 7.27 0.37 2.68e-12 Coronary artery disease; CRC cis rs12476592 0.602 rs262484 chr2:63878015 A/G cg10828910 chr2:63850056 LOC388955 0.48 6.06 0.32 3.74e-9 Childhood ear infection; CRC cis rs9486719 1.000 rs2472888 chr6:96865501 T/C cg06623918 chr6:96969491 KIAA0776 0.81 9.48 0.46 5.18e-19 Migraine;Coronary artery disease; CRC cis rs8060686 0.641 rs9923710 chr16:68224018 C/T cg26727032 chr16:67993705 SLC12A4 -0.56 -7.5 -0.38 6e-13 HDL cholesterol;Metabolic syndrome; CRC trans rs9465187 0.542 rs2208859 chr6:18699420 A/G cg11414540 chr19:19313888 NR2C2AP 0.47 6.06 0.32 3.64e-9 Colonoscopy-negative controls vs population controls; CRC cis rs6952808 0.693 rs10950413 chr7:1912988 A/G cg21782813 chr7:2030301 MAD1L1 0.39 7.17 0.37 5.06e-12 Bipolar disorder and schizophrenia; CRC cis rs6088813 1.000 rs6088813 chr20:33975181 C/A cg14752227 chr20:34000481 UQCC -0.36 -5.62 -0.3 3.99e-8 Height; CRC cis rs4803468 1.000 rs284648 chr19:41926790 T/C cg09537434 chr19:41945824 ATP5SL -0.97 -18.39 -0.71 1.96e-52 Height; CRC cis rs1448094 0.512 rs6539931 chr12:86247473 C/T cg19622623 chr12:86230825 RASSF9 -0.41 -6.76 -0.35 6.45e-11 Major depressive disorder; CRC cis rs2811415 0.627 rs1984451 chr3:127768462 C/G cg13719885 chr3:127795394 NA -0.39 -5.99 -0.31 5.56e-9 Lung function (FEV1/FVC); CRC cis rs10504229 0.728 rs17804666 chr8:58154473 C/T cg08219700 chr8:58056026 NA 0.45 5.74 0.3 2.11e-8 Developmental language disorder (linguistic errors); CRC cis rs938554 0.513 rs3775947 chr4:9995240 C/T cg00071950 chr4:10020882 SLC2A9 0.44 6.92 0.36 2.4e-11 Blood metabolite levels; CRC cis rs6952808 0.692 rs10950473 chr7:1999453 G/A cg22963979 chr7:1858916 MAD1L1 -0.5 -7.14 -0.37 5.86e-12 Bipolar disorder and schizophrenia; CRC cis rs9287719 0.967 rs2110778 chr2:10748970 A/T cg00105475 chr2:10696890 NA 0.45 7.17 0.37 4.87e-12 Prostate cancer; CRC cis rs787274 0.718 rs4979173 chr9:115627699 A/C cg13803584 chr9:115635662 SNX30 -0.66 -6.35 -0.33 7.01e-10 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs1881797 1.000 rs66845073 chr1:247688010 C/T cg11166453 chr1:247681781 NA 0.42 6.95 0.36 1.93e-11 Acute lymphoblastic leukemia (childhood); CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg07940793 chr17:79603854 NPLOC4 0.38 5.98 0.31 5.84e-9 Obesity-related traits; CRC cis rs172166 0.694 rs203893 chr6:28062066 C/A cg25164649 chr6:28176230 NA 0.62 8.87 0.44 4.75e-17 Cardiac Troponin-T levels; CRC cis rs12477438 0.520 rs10865029 chr2:99718298 C/T cg26064155 chr2:99771622 LIPT1;TSGA10 0.88 16.24 0.67 5.52e-44 Chronic sinus infection; CRC cis rs73206853 0.764 rs76142162 chr12:110884307 C/G cg12870014 chr12:110450643 ANKRD13A 0.83 9.91 0.48 1.94e-20 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC cis rs7727544 0.684 rs272869 chr5:131677997 A/G cg07395648 chr5:131743802 NA -0.41 -6.43 -0.33 4.62e-10 Blood metabolite levels; CRC cis rs853679 0.517 rs35227624 chr6:28132726 A/G cg06470822 chr6:28175283 NA 1.03 13.59 0.6 1.04e-33 Depression; CRC cis rs11785693 0.862 rs7009771 chr8:4990189 C/T cg26367366 chr8:4980734 NA 0.79 9.67 0.47 1.27e-19 Neuroticism (multi-trait analysis);Neuroticism; CRC cis rs4862750 0.872 rs9997374 chr4:187877549 T/A cg22105103 chr4:187893119 NA 0.64 11.87 0.55 2.79e-27 Lobe attachment (rater-scored or self-reported); CRC cis rs2072499 1.000 rs2540173 chr1:156188214 A/G cg06970220 chr1:156163860 SLC25A44 0.52 7.56 0.38 4.01e-13 Testicular germ cell tumor; CRC cis rs2882667 0.858 rs11957527 chr5:138404895 T/C cg04439458 chr5:138467593 SIL1 -0.34 -5.8 -0.3 1.55e-8 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs3126085 0.825 rs7535078 chr1:152222915 T/C cg09127314 chr1:152161683 NA 0.5 6.59 0.34 1.75e-10 Atopic dermatitis; CRC cis rs735396 1.000 rs2259852 chr12:121434833 G/A cg02403541 chr12:121454288 C12orf43 0.44 6.67 0.34 1.11e-10 N-glycan levels; CRC trans rs1814175 0.817 rs4405313 chr11:50013636 G/A cg11707556 chr5:10655725 ANKRD33B -0.43 -8.45 -0.42 9.43e-16 Height; CRC cis rs514406 0.825 rs6588441 chr1:53223494 G/A cg25767906 chr1:53392781 SCP2 0.45 7.12 0.37 6.95e-12 Monocyte count; CRC trans rs7301826 0.627 rs7315707 chr12:131272819 A/G cg13402217 chr1:151584375 SNX27 0.49 6.1 0.32 2.9e-9 Plasma plasminogen activator levels; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg12868349 chr11:71639594 RNF121;LOC100133315 0.5 7.24 0.37 3.27e-12 Response to antipsychotic treatment; CRC cis rs10504229 0.724 rs73603871 chr8:58107612 A/G cg24829409 chr8:58192753 C8orf71 -0.56 -8.01 -0.4 2.05e-14 Developmental language disorder (linguistic errors); CRC cis rs13191362 0.810 rs35509380 chr6:163053028 A/G cg14584255 chr6:163149320 PACRG;PARK2 0.43 6.05 0.32 3.89e-9 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs9325144 0.534 rs1843866 chr12:38703160 G/T cg13010199 chr12:38710504 ALG10B 0.41 6.02 0.32 4.65e-9 Morning vs. evening chronotype; CRC cis rs9894429 1.000 rs4074915 chr17:79579230 G/A cg21028142 chr17:79581711 NPLOC4 -0.39 -8.62 -0.43 2.89e-16 Eye color traits; CRC cis rs477692 0.583 rs12415589 chr10:131428336 C/G cg05714579 chr10:131428358 MGMT -0.91 -14.4 -0.62 8.62e-37 Response to temozolomide; CRC cis rs500492 0.508 rs2744147 chr16:1073146 C/G cg09274344 chr16:1078689 NA 0.39 6.34 0.33 7.65e-10 Polycystic ovary syndrome; CRC cis rs8040855 0.627 rs12905036 chr15:85637788 C/T cg10818794 chr15:86012489 AKAP13 -0.42 -5.65 -0.3 3.41e-8 Bulimia nervosa; CRC cis rs1862618 0.853 rs832569 chr5:56154584 T/A cg22800045 chr5:56110881 MAP3K1 0.59 6.45 0.33 4.05e-10 Initial pursuit acceleration; CRC cis rs782590 0.748 rs782634 chr2:55897700 T/C cg18811423 chr2:55921094 PNPT1 0.82 14.5 0.62 3.42e-37 Metabolic syndrome; CRC cis rs1799949 1.000 rs1973646 chr17:41310495 T/C cg05368731 chr17:41323189 NBR1 0.66 9.6 0.47 2.1e-19 Menopause (age at onset); CRC cis rs34375054 0.526 rs4412800 chr12:125674742 C/T cg06987292 chr12:125626746 AACS 0.36 5.64 0.3 3.61e-8 Post bronchodilator FEV1/FVC ratio; CRC cis rs5750830 0.621 rs743838 chr22:39824707 T/G cg24399712 chr22:39784796 NA -0.48 -9.03 -0.45 1.43e-17 Intelligence (multi-trait analysis); CRC cis rs3011225 0.710 rs3011222 chr1:44317545 C/T cg12908607 chr1:44402522 ARTN -0.53 -9.51 -0.46 4.11e-19 Amyotrophic lateral sclerosis (age of onset); CRC cis rs8170 1.000 rs10425939 chr19:17397244 C/T cg04749549 chr19:17459798 NA -0.44 -5.84 -0.31 1.23e-8 Breast cancer (estrogen-receptor negative);Breast Cancer in BRCA1 mutation carriers;Ovarian cancer;Breast cancer;Epithelial ovarian cancer; CRC cis rs2380220 0.678 rs4308568 chr6:96009525 A/C cg07718321 chr6:96025334 MANEA -0.54 -6.91 -0.36 2.55e-11 Behavioural disinhibition (generation interaction); CRC cis rs10504229 0.689 rs17801390 chr8:58054768 T/C cg24829409 chr8:58192753 C8orf71 -0.68 -8.25 -0.41 3.95e-15 Developmental language disorder (linguistic errors); CRC cis rs10878977 1.000 rs17106576 chr12:69823491 T/G cg20891283 chr12:69753455 YEATS4 -0.5 -6.42 -0.33 4.86e-10 Colorectal cancer; CRC cis rs72627509 0.857 rs56155140 chr4:57824451 G/A cg26694713 chr4:57773883 REST 0.47 5.62 0.3 4.12e-8 Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); CRC cis rs9914988 0.778 rs9907185 chr17:27122414 C/T cg12682573 chr17:27188876 MIR451;MIR144 0.58 7.99 0.4 2.37e-14 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs7937682 0.921 rs10789841 chr11:111469582 T/C cg19812747 chr11:111475976 SIK2 0.53 7.65 0.39 2.23e-13 Primary sclerosing cholangitis; CRC cis rs875971 0.545 rs6970498 chr7:65740895 A/G cg18876405 chr7:65276391 NA 0.46 6.34 0.33 7.75e-10 Aortic root size; CRC cis rs28386778 1.000 rs2665849 chr17:61953670 T/C cg23090583 chr17:61904693 PSMC5;FTSJ3 1.03 19.47 0.73 1.07e-56 Prudent dietary pattern; CRC cis rs1707322 0.752 rs28438704 chr1:46170544 G/A cg03146154 chr1:46216737 IPP 0.67 9.82 0.48 3.95e-20 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs12618769 0.652 rs1139829 chr2:99225168 C/T cg18455616 chr2:99124870 INPP4A 0.36 5.86 0.31 1.14e-8 Bipolar disorder; CRC trans rs9858542 0.953 rs1873625 chr3:49666964 C/A cg21582582 chr3:182698605 DCUN1D1 -0.53 -6.39 -0.33 5.65e-10 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC trans rs11343 0.675 rs7359333 chr16:19262344 A/T cg15043615 chr17:74025708 NA -0.46 -6.15 -0.32 2.26e-9 Parkinson's disease; CRC cis rs67311347 1.000 rs951560 chr3:40463471 A/G cg24209194 chr3:40518798 ZNF619 0.43 6.56 0.34 2.05e-10 Renal cell carcinoma; CRC cis rs6565180 0.962 rs6565182 chr16:30374381 C/T cg01392867 chr16:30410429 ZNF48 -0.36 -5.69 -0.3 2.83e-8 Tonsillectomy; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg03662467 chr18:43753538 C18orf25 0.45 6.29 0.33 9.84e-10 Response to antipsychotic treatment; CRC cis rs367615 0.552 rs3828603 chr5:108712068 G/C cg17395555 chr5:108820864 NA -0.36 -6.88 -0.35 3.1e-11 Colorectal cancer (SNP x SNP interaction); CRC cis rs12024301 0.557 rs59983196 chr1:183591797 C/T cg11505048 chr1:183622726 RGL1;APOBEC4 0.76 6.93 0.36 2.16e-11 Peripheral arterial disease (traffic-related air pollution interaction); CRC trans rs2303319 0.504 rs12465645 chr2:162437639 A/G cg18122310 chr12:50236657 BCDIN3D -0.73 -6.01 -0.31 4.93e-9 Cognitive function; CRC cis rs473651 0.904 rs508274 chr2:239337723 G/A cg21699342 chr2:239360505 ASB1 0.58 10.55 0.5 1.29e-22 Multiple system atrophy; CRC cis rs7917772 0.503 rs11191347 chr10:104351617 C/T cg11453585 chr10:104263688 ACTR1A;SUFU 0.89 16.03 0.66 3.81e-43 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC cis rs4478858 0.735 rs7547897 chr1:31797593 G/A cg00250761 chr1:31883323 NA -0.44 -8.5 -0.42 6.71e-16 Alcohol dependence; CRC cis rs731174 0.797 rs539585 chr1:38148123 T/G cg06917450 chr1:38156652 C1orf109 -0.52 -7.23 -0.37 3.42e-12 Prostate cancer (SNP x SNP interaction); CRC cis rs2982552 0.844 rs3020346 chr6:152056771 C/T cg22157087 chr6:152012887 ESR1 -0.4 -6.17 -0.32 1.96e-9 Bone properties (heel); CRC cis rs8180040 0.676 rs66564457 chr3:47020072 G/A cg27129171 chr3:47204927 SETD2 0.65 10.27 0.49 1.21e-21 Colorectal cancer; CRC cis rs11997175 0.646 rs10954936 chr8:33686165 C/T cg04338863 chr8:33670619 NA 0.44 6.95 0.36 1.96e-11 Body mass index; CRC cis rs2050392 0.517 rs619864 chr10:30750950 A/G cg18806716 chr10:30721971 MAP3K8 0.62 8.91 0.44 3.54e-17 Inflammatory bowel disease; CRC cis rs5769707 0.967 rs2187891 chr22:49994094 C/T cg20744362 chr22:50050164 C22orf34 0.3 6.05 0.32 3.93e-9 Monocyte count;Monocyte percentage of white cells; CRC cis rs7552404 1.000 rs11161521 chr1:76216330 T/C cg10523679 chr1:76189770 ACADM 0.85 11.63 0.54 2.03e-26 Blood metabolite levels;Acylcarnitine levels; CRC cis rs11677416 1.000 rs2071375 chr2:113535438 C/T cg27083787 chr2:113543245 IL1A 0.47 6.63 0.34 1.42e-10 Response to antipsychotic treatment in schizophrenia (working memory); CRC cis rs1218582 0.682 rs12046459 chr1:154912017 A/C cg24250549 chr1:154909240 PMVK 0.62 10.33 0.49 7.53e-22 Prostate cancer; CRC cis rs11997175 0.574 rs12541661 chr8:33649856 T/G ch.8.33884649F chr8:33765107 NA 0.47 7.45 0.38 8.11e-13 Body mass index; CRC trans rs7647973 0.626 rs7649428 chr3:49868876 A/T cg21665057 chr3:196295764 WDR53;FBXO45 0.64 6.89 0.36 2.81e-11 Menarche (age at onset); CRC cis rs4730250 0.707 rs6960148 chr7:106786142 A/G cg02696742 chr7:106810147 HBP1 0.6 6.81 0.35 4.71e-11 Osteoarthritis; CRC cis rs6540559 0.932 rs764093 chr1:209983331 A/G cg25204440 chr1:209979598 IRF6 0.49 6.89 0.36 2.78e-11 Cleft lip with or without cleft palate; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg01860201 chr4:75720019 BTC 0.39 6.01 0.31 5e-9 Liver disease severity in Alagille syndrome; CRC cis rs939584 0.935 rs13387939 chr2:637498 C/A cg03610516 chr2:642275 NA 0.43 5.77 0.3 1.82e-8 Body mass index; CRC cis rs7731657 0.537 rs2419756 chr5:130259779 T/C cg08523029 chr5:130500466 HINT1 0.43 5.7 0.3 2.61e-8 Fasting plasma glucose; CRC cis rs847577 0.748 rs940430 chr7:97716540 A/G cg24562669 chr7:97807699 LMTK2 0.76 16.49 0.67 5.94e-45 Breast cancer; CRC cis rs6541297 0.793 rs6692319 chr1:230284375 C/T cg05784532 chr1:230284198 GALNT2 0.43 5.79 0.3 1.66e-8 Coronary artery disease; CRC cis rs2404602 0.536 rs11072599 chr15:76774508 T/C cg03037974 chr15:76606532 NA 0.66 11.49 0.54 6.38e-26 Blood metabolite levels; CRC cis rs11039389 1 rs11039389 chr11:47796062 T/C cg20307385 chr11:47447363 PSMC3 -0.49 -6.55 -0.34 2.19e-10 Neuroticism; CRC cis rs4662945 0.525 rs4662951 chr2:130256272 C/T cg05962382 chr2:130345044 NA -0.44 -7.61 -0.39 2.86e-13 Response to cytidine analogues (gemcitabine); CRC cis rs7487075 0.619 rs10785627 chr12:46824229 G/A cg22049899 chr12:47219821 SLC38A4 0.31 5.66 0.3 3.29e-8 Itch intensity from mosquito bite; CRC cis rs853679 0.517 rs4713143 chr6:28106759 A/C cg25164649 chr6:28176230 NA 0.76 9.53 0.46 3.71e-19 Depression; CRC trans rs2295389 0.932 rs4900478 chr14:101315481 A/C cg27513308 chr1:32797653 HDAC1 0.32 6.0 0.31 5.35e-9 Breast cancer; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg20284698 chr3:48956327 C3orf71;ARIH2 0.4 7.41 0.38 1.1e-12 Liver disease severity in Alagille syndrome; CRC cis rs853679 0.517 rs9393886 chr6:28050039 T/G cg23161317 chr6:28129485 ZNF389 0.5 6.21 0.32 1.57e-9 Depression; CRC cis rs6496667 0.821 rs6496674 chr15:90976340 G/T cg04176472 chr15:90893244 GABARAPL3 0.59 7.97 0.4 2.62e-14 Rheumatoid arthritis; CRC cis rs5769765 0.862 rs9616392 chr22:50314705 G/A cg02269571 chr22:50332266 NA -0.6 -7.97 -0.4 2.7e-14 Schizophrenia; CRC cis rs9314323 0.693 rs13264882 chr8:26224240 G/T cg13160058 chr8:26243215 BNIP3L -0.49 -7.98 -0.4 2.47e-14 Red cell distribution width; CRC trans rs6550704 0.687 rs9865314 chr3:22634337 A/G cg03183877 chr10:27444699 YME1L1;MASTL -0.41 -5.97 -0.31 6.22e-9 Daytime sleep phenotypes; CRC cis rs362272 0.524 rs2749781 chr4:3346617 T/C cg11522145 chr4:3412961 RGS12 -0.4 -6.07 -0.32 3.46e-9 Serum sulfate level; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg25699533 chr19:18682841 UBA52 0.49 6.98 0.36 1.62e-11 Response to antipsychotic treatment; CRC cis rs12995491 0.731 rs12992162 chr2:88508773 G/C cg07952391 chr2:88470173 THNSL2 -0.39 -5.73 -0.3 2.28e-8 Response to metformin (IC50); CRC cis rs6835098 0.962 rs6851632 chr4:174109611 A/G cg08422745 chr4:174089978 GALNT7 -0.95 -15.04 -0.64 2.78e-39 Dementia and core Alzheimer's disease neuropathologic changes; CRC cis rs7772486 0.686 rs702314 chr6:146003510 G/A cg23711669 chr6:146136114 FBXO30 -0.65 -10.79 -0.51 1.91e-23 Lobe attachment (rater-scored or self-reported); CRC trans rs2303319 0.504 rs16845960 chr2:162501613 A/G cg12500891 chr11:57225987 NA -0.67 -6.03 -0.32 4.51e-9 Cognitive function; CRC cis rs9611565 0.765 rs132908 chr22:41801795 G/A cg06634786 chr22:41940651 POLR3H 0.67 7.61 0.39 2.99e-13 Vitiligo; CRC cis rs1580019 0.563 rs4723169 chr7:32567577 G/A cg06627557 chr7:32535165 LSM5;AVL9 0.96 18.12 0.71 2.23e-51 Cognitive ability; CRC trans rs4714291 0.674 rs3008837 chr6:40046725 C/T cg02267698 chr19:7991119 CTXN1 -0.45 -6.06 -0.32 3.81e-9 Strep throat; CRC cis rs6502050 0.835 rs3935128 chr17:80113414 T/C cg09264619 chr17:80180166 NA -0.34 -5.81 -0.3 1.5e-8 Life satisfaction; CRC cis rs910316 1.000 rs876402 chr14:75601862 C/T cg11812906 chr14:75593930 NEK9 -0.63 -10.25 -0.49 1.36e-21 Height; CRC cis rs34172651 0.517 rs2303084 chr16:24834581 G/C cg00339695 chr16:24857497 SLC5A11 0.4 7.67 0.39 1.98e-13 Intelligence (multi-trait analysis); CRC cis rs728616 0.867 rs17885031 chr10:81696091 G/A cg11900509 chr10:81946545 ANXA11 -0.65 -6.71 -0.35 8.77e-11 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs12477438 0.765 rs6735801 chr2:99657995 G/T cg14399236 chr2:99771627 LIPT1;TSGA10 -0.6 -8.19 -0.41 6.03e-15 Chronic sinus infection; CRC cis rs875971 0.929 rs10950041 chr7:65973875 T/C cg12463550 chr7:65579703 CRCP 0.47 6.79 0.35 5.17e-11 Aortic root size; CRC cis rs11105298 0.891 rs10858889 chr12:89902604 G/A cg08166232 chr12:89918718 WDR51B;GALNT4 -0.6 -7.67 -0.39 1.94e-13 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; CRC cis rs912057 0.585 rs1745341 chr6:6744990 T/C cg06612196 chr6:6737390 NA 0.54 8.59 0.43 3.5e-16 Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction); CRC cis rs6963495 0.818 rs73190133 chr7:105147821 G/C cg13798780 chr7:105162888 PUS7 0.66 8.06 0.41 1.39e-14 Bipolar disorder (body mass index interaction); CRC cis rs763014 0.932 rs2384975 chr16:651115 G/T cg00802000 chr16:706648 WDR90 -0.44 -6.44 -0.33 4.26e-10 Height; CRC cis rs7909074 0.899 rs2026428 chr10:45389452 T/C cg04218760 chr10:45406644 TMEM72 -0.34 -9.55 -0.47 3.1400000000000002e-19 Mean corpuscular volume; CRC cis rs644799 0.710 rs3748253 chr11:95519506 G/A cg25622487 chr11:95524042 FAM76B;CEP57 0.8 13.42 0.59 4.69e-33 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs12497850 0.897 rs7432989 chr3:49105136 A/G cg07636037 chr3:49044803 WDR6 1.04 18.16 0.71 1.47e-51 Parkinson's disease; CRC cis rs4481887 0.741 rs6681758 chr1:248540413 T/A cg26353448 chr1:248524236 OR2T4 -0.33 -6.33 -0.33 8.18e-10 Common traits (Other); CRC cis rs72945132 1.000 rs72945129 chr11:70110808 C/T cg14191688 chr11:70257035 CTTN 0.51 6.3 0.33 9.8e-10 Coronary artery disease; CRC cis rs1552244 0.515 rs67342818 chr3:10166406 G/A cg13047869 chr3:10149882 C3orf24 0.54 6.49 0.34 3.1e-10 Alzheimer's disease; CRC cis rs1552244 0.808 rs17032306 chr3:10091399 C/G cg13047869 chr3:10149882 C3orf24 0.53 7.44 0.38 8.73e-13 Alzheimer's disease; CRC cis rs12995491 0.731 rs13019346 chr2:88509321 A/G cg18490616 chr2:88469792 THNSL2 -0.39 -5.66 -0.3 3.28e-8 Response to metformin (IC50); CRC cis rs2985684 0.846 rs11157693 chr14:50048426 T/C cg23565292 chr14:50234668 KLHDC2 -0.43 -6.16 -0.32 2.13e-9 Carotid intima media thickness; CRC cis rs28386778 0.897 rs8069969 chr17:61822223 T/G cg22520471 chr17:61851767 DDX42;CCDC47 0.74 11.56 0.54 3.69e-26 Prudent dietary pattern; CRC cis rs4713118 0.662 rs9468276 chr6:28027688 A/C cg18032046 chr6:28092343 ZSCAN16 -0.5 -6.33 -0.33 7.89e-10 Parkinson's disease; CRC cis rs968567 0.638 rs7943728 chr11:61547068 G/A cg21709803 chr11:61594965 FADS2 -0.57 -6.73 -0.35 7.66e-11 Blood metabolite levels;Rheumatoid arthritis;Vitiligo;Glycerophospholipid levels; CRC cis rs11098499 0.863 rs10004484 chr4:120442428 C/T cg09307838 chr4:120376055 NA 0.68 10.35 0.5 6.37e-22 Corneal astigmatism; CRC cis rs875971 0.895 rs12698520 chr7:65918707 C/A cg12463550 chr7:65579703 CRCP 0.48 6.78 0.35 5.46e-11 Aortic root size; CRC cis rs1552244 0.554 rs59465469 chr3:9990800 G/C cg16606324 chr3:10149918 C3orf24 0.47 7.29 0.37 2.29e-12 Alzheimer's disease; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg13937841 chr10:28821190 WAC 0.46 5.97 0.31 6.17e-9 Thyroid stimulating hormone; CRC cis rs7726839 0.540 rs3749618 chr5:602650 A/G cg09021430 chr5:549028 NA -0.73 -8.38 -0.42 1.56e-15 Obesity-related traits; CRC cis rs10504229 0.775 rs55825382 chr8:58157605 G/A cg20607798 chr8:58055168 NA 0.46 5.66 0.3 3.31e-8 Developmental language disorder (linguistic errors); CRC cis rs9291683 0.507 rs3796837 chr4:10011321 C/G cg11266682 chr4:10021025 SLC2A9 0.53 10.91 0.52 7.53e-24 Bone mineral density; CRC cis rs2857891 0.695 rs2468986 chr11:6986027 G/C cg04053776 chr11:6947353 ZNF215 0.37 5.73 0.3 2.22e-8 Response to cytadine analogues (cytosine arabinoside); CRC cis rs4731207 0.697 rs4360235 chr7:124526542 C/T cg23710748 chr7:124431027 NA -0.38 -6.08 -0.32 3.42e-9 Cutaneous malignant melanoma; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg08929303 chr1:207227076 PFKFB2 0.31 6.53 0.34 2.44e-10 Intelligence (multi-trait analysis); CRC trans rs1814175 0.645 rs2140602 chr11:50022800 G/C cg11707556 chr5:10655725 ANKRD33B -0.52 -10.25 -0.49 1.36e-21 Height; CRC cis rs644799 0.965 rs534488 chr11:95562327 G/A cg25622487 chr11:95524042 FAM76B;CEP57 0.76 11.99 0.55 9.59e-28 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg05663655 chr7:107532014 DLD 0.48 6.23 0.32 1.4e-9 Thyroid stimulating hormone; CRC cis rs12908161 1.000 rs60957376 chr15:85280792 T/G cg17507749 chr15:85114479 UBE2QP1 0.64 9.4 0.46 9.36e-19 Schizophrenia; CRC cis rs526821 0.553 rs510095 chr11:55289154 T/C cg04317927 chr11:55418816 OR4S2 0.41 6.81 0.35 4.52e-11 Pediatric bone mineral density (spine); CRC cis rs7208859 0.623 rs7214570 chr17:29147164 A/G cg01831904 chr17:28903510 LRRC37B2 -0.56 -5.99 -0.31 5.48e-9 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs6951245 1.000 rs884977 chr7:1066410 T/C cg21664854 chr7:1097933 C7orf50;GPR146 0.55 7.1 0.36 7.68e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs394563 0.781 rs61516098 chr6:149794289 A/T cg03678062 chr6:149772716 ZC3H12D -0.37 -6.3 -0.33 9.56e-10 Dupuytren's disease; CRC cis rs2070677 0.932 rs2987786 chr10:135365303 C/T cg20169779 chr10:135381914 SYCE1 -0.84 -11.77 -0.54 6.09e-27 Gout; CRC cis rs2857891 1.000 rs2857891 chr11:6962957 C/T cg04053776 chr11:6947353 ZNF215 0.5 6.87 0.35 3.21e-11 Response to cytadine analogues (cytosine arabinoside); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg17808901 chr3:39093368 WDR48 0.46 6.73 0.35 7.36e-11 Response to antipsychotic treatment; CRC cis rs73206853 0.563 rs7960749 chr12:111164369 T/C cg12870014 chr12:110450643 ANKRD13A 0.75 8.89 0.44 4.07e-17 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC cis rs6502050 0.805 rs11651863 chr17:80084539 T/C cg11859384 chr17:80120422 CCDC57 0.37 5.83 0.31 1.29e-8 Life satisfaction; CRC cis rs9292777 0.704 rs348594 chr5:40323938 A/G cg09067459 chr5:40385259 NA -0.55 -9.56 -0.47 2.88e-19 Crohn's disease;Multiple sclerosis; CRC cis rs13108904 0.840 rs13106092 chr4:1257290 T/A cg02018176 chr4:1364513 KIAA1530 0.45 7.4 0.38 1.17e-12 Obesity-related traits; CRC trans rs3749237 0.964 rs34522271 chr3:49808517 A/G cg21665057 chr3:196295764 WDR53;FBXO45 0.55 7.78 0.39 9.69e-14 Resting heart rate; CRC cis rs1005224 0.853 rs9323616 chr14:76151697 T/C cg04684003 chr14:76127793 TTLL5;C14orf1 -0.49 -7.0 -0.36 1.48e-11 Large artery stroke; CRC cis rs3820068 0.581 rs68052904 chr1:15916714 T/C cg24675056 chr1:15929824 NA 0.47 6.17 0.32 2.03e-9 Systolic blood pressure; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg17002091 chr14:100772763 SLC25A29;MIR345 0.45 6.32 0.33 8.35e-10 Response to antipsychotic treatment; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg26861593 chr1:161195893 TOMM40L 0.46 6.59 0.34 1.76e-10 Response to antipsychotic treatment; CRC cis rs9457247 0.663 rs9459839 chr6:167431829 T/C cg07741184 chr6:167504864 NA 0.35 6.29 0.33 1.04e-9 Crohn's disease; CRC cis rs736408 0.527 rs2336147 chr3:52626443 T/C cg18099408 chr3:52552593 STAB1 -0.54 -9.84 -0.48 3.43e-20 Bipolar disorder; CRC cis rs7259376 0.748 rs1230305 chr19:22641917 C/T cg02657401 chr19:22469223 NA -0.35 -7.55 -0.38 4.19e-13 Menopause (age at onset); CRC cis rs703842 0.616 rs10783851 chr12:58231155 A/G cg00677455 chr12:58241039 CTDSP2 -0.78 -11.01 -0.52 3.31e-24 Multiple sclerosis; CRC cis rs6502050 0.698 rs67143649 chr17:80117772 C/G cg22110888 chr17:80059540 CCDC57 0.4 6.45 0.34 3.95e-10 Life satisfaction; CRC cis rs10464366 0.544 rs9639812 chr7:39192058 C/T cg21665744 chr7:39171113 POU6F2 0.45 5.93 0.31 7.73e-9 IgG glycosylation; CRC cis rs9612 1.000 rs346544 chr19:44256205 A/G cg08581076 chr19:44259116 C19orf61 0.46 5.97 0.31 6.09e-9 Exhaled nitric oxide output; CRC cis rs4964805 0.954 rs11111785 chr12:104189056 A/G cg02344784 chr12:104178138 NT5DC3 0.56 8.51 0.42 6.45e-16 Attention deficit hyperactivity disorder; CRC cis rs1322512 0.837 rs2800627 chr6:153006507 C/A cg03415253 chr6:152958462 SYNE1 0.4 6.03 0.32 4.39e-9 Tonometry; CRC cis rs2346177 0.875 rs4413204 chr2:46647092 C/G cg26688816 chr2:46740690 ATP6V1E2 -0.53 -8.49 -0.42 6.98e-16 HDL cholesterol; CRC cis rs9768139 0.901 rs56113702 chr7:158117938 C/T cg23298862 chr7:158159286 PTPRN2 -0.48 -7.91 -0.4 3.98e-14 Calcium levels; CRC cis rs12824058 0.798 rs4759652 chr12:130808771 C/T cg24838063 chr12:130822603 PIWIL1 0.59 9.77 0.47 5.65e-20 Menopause (age at onset); CRC cis rs40363 0.645 rs250627 chr16:3527050 G/A cg22508957 chr16:3507546 NAT15 0.59 9.18 0.45 4.97e-18 Tuberculosis; CRC cis rs1005277 0.579 rs2474572 chr10:38385316 A/G cg25427524 chr10:38739819 LOC399744 -0.77 -14.06 -0.61 1.68e-35 Extrinsic epigenetic age acceleration; CRC cis rs28386778 0.897 rs2584610 chr17:61934783 T/C cg11494091 chr17:61959527 GH2 0.62 10.5 0.5 1.92e-22 Prudent dietary pattern; CRC cis rs9399137 0.507 rs4289677 chr6:135275485 A/G cg24558204 chr6:135376177 HBS1L 0.61 8.79 0.44 8.32e-17 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; CRC cis rs6694672 0.681 rs615647 chr1:197188908 T/C cg13682187 chr1:196946512 CFHR5 0.49 6.92 0.36 2.31e-11 Asthma; CRC cis rs10193935 1.000 rs4048 chr2:42424595 A/C cg27598129 chr2:42591480 NA -0.72 -7.48 -0.38 7.03e-13 Colonoscopy-negative controls vs population controls; CRC trans rs561341 1.000 rs497479 chr17:30328605 C/T cg27661571 chr11:113659931 NA -0.9 -10.42 -0.5 3.66e-22 Hip circumference adjusted for BMI; CRC cis rs9910055 0.530 rs11652651 chr17:42302907 A/G cg19774624 chr17:42201019 HDAC5 0.39 5.76 0.3 1.88e-8 Total body bone mineral density; CRC cis rs2303759 0.918 rs2288480 chr19:49867016 C/G cg22307029 chr19:49891270 CCDC155 0.68 9.81 0.48 4.26e-20 Multiple sclerosis; CRC cis rs12586317 0.883 rs4982254 chr14:35755737 C/T cg16230307 chr14:35515116 FAM177A1 0.53 6.24 0.33 1.33e-9 Psoriasis; CRC cis rs4862750 0.872 rs6821507 chr4:187876829 G/T cg07414643 chr4:187882934 NA -0.37 -6.53 -0.34 2.53e-10 Lobe attachment (rater-scored or self-reported); CRC cis rs11785400 0.793 rs4371985 chr8:143737279 C/T cg24634471 chr8:143751801 JRK 0.45 6.29 0.33 1.03e-9 Schizophrenia; CRC cis rs12900413 0.687 rs35060998 chr15:90310294 A/G cg24249390 chr15:90295951 MESP1 -0.58 -9.29 -0.46 2.2e-18 Coronary artery aneurysm in Kawasaki disease; CRC cis rs1129187 0.755 rs4714638 chr6:42917017 A/G cg10862848 chr6:42927986 GNMT -0.38 -8.89 -0.44 3.97e-17 Alzheimer's disease in APOE e4+ carriers; CRC cis rs6951245 1.000 rs113066613 chr7:1094128 T/C cg07217954 chr7:1067459 C7orf50 0.55 5.71 0.3 2.48e-8 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs7647973 1.000 rs2140270 chr3:49439440 A/G cg20833759 chr3:49053208 WDR6;DALRD3 -0.55 -8.2 -0.41 5.38e-15 Menarche (age at onset); CRC cis rs875971 0.545 rs6460281 chr7:65681115 A/C cg18876405 chr7:65276391 NA 0.47 6.57 0.34 1.94e-10 Aortic root size; CRC cis rs2404602 1.000 rs2896954 chr15:76851692 C/A cg03037974 chr15:76606532 NA 0.63 10.79 0.51 1.93e-23 Blood metabolite levels; CRC cis rs2070488 0.775 rs6599208 chr3:38558104 A/C cg01465620 chr3:38496096 LOC100128640;ACVR2B -0.74 -12.44 -0.57 2.29e-29 Electrocardiographic conduction measures; CRC cis rs9487051 0.872 rs1111866 chr6:109610846 A/C cg01475377 chr6:109611718 NA 0.49 9.23 0.45 3.38e-18 Reticulocyte fraction of red cells; CRC cis rs2346160 0.867 rs206975 chr6:167690356 A/G cg04673565 chr6:167680447 NA -0.38 -6.52 -0.34 2.64e-10 Parental extreme longevity (95 years and older); CRC cis rs7762018 1.000 rs74900588 chr6:170102180 A/C cg19338460 chr6:170058176 WDR27 -0.73 -7.89 -0.4 4.53e-14 Thiazide-induced adverse metabolic effects in hypertensive patients; CRC trans rs11764590 0.694 rs4721359 chr7:2104951 A/G cg11693508 chr17:37793320 STARD3 0.48 6.47 0.34 3.46e-10 Neuroticism; CRC trans rs2303319 0.504 rs62189055 chr2:162625749 C/A cg20024234 chr21:43431083 ZNF295 -0.68 -6.17 -0.32 2.02e-9 Cognitive function; CRC cis rs977987 0.778 rs34222958 chr16:75398252 C/T cg03315344 chr16:75512273 CHST6 0.54 9.07 0.45 1.13e-17 Dupuytren's disease; CRC cis rs910316 1.000 rs1047418 chr14:75605792 A/G cg03030879 chr14:75389066 RPS6KL1 -0.48 -7.51 -0.38 5.59e-13 Height; CRC trans rs6472235 0.837 rs2357568 chr8:66917002 C/G cg07884673 chr3:53033167 SFMBT1 -0.45 -6.12 -0.32 2.62e-9 Myopia (pathological);Plateletcrit; CRC cis rs4727027 0.933 rs13225884 chr7:148857795 A/G cg12479418 chr7:148823350 ZNF425;ZNF398 0.41 5.65 0.3 3.51e-8 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC cis rs6586163 0.527 rs12775501 chr10:90750909 C/T cg03111039 chr10:90751583 FAS;ACTA2 0.83 12.58 0.57 6.62e-30 Chronic lymphocytic leukemia; CRC cis rs79387448 0.745 rs76746266 chr2:103124920 C/T cg00507830 chr2:103233733 NA 0.51 5.8 0.3 1.55e-8 Gut microbiota (bacterial taxa); CRC cis rs7639513 0.590 rs3729931 chr3:12626516 A/G cg23032965 chr3:12705835 RAF1 -0.59 -9.42 -0.46 7.96e-19 Itch intensity from mosquito bite; CRC cis rs35110281 0.776 rs1073522 chr21:45009219 T/A cg01579765 chr21:45077557 HSF2BP -0.39 -7.48 -0.38 6.73e-13 Mean corpuscular volume; CRC trans rs300774 0.841 rs410690 chr2:203346 G/A cg02806739 chr17:80273242 CD7 -0.5 -6.01 -0.31 5.02e-9 Suicide attempts in bipolar disorder; CRC trans rs10982213 0.830 rs2274163 chr9:117188714 C/T cg04713951 chr22:38966166 DMC1 0.39 6.13 0.32 2.51e-9 Interleukin-6 levels; CRC cis rs2046867 0.818 rs17010184 chr3:72870242 A/T cg25664220 chr3:72788482 NA 0.47 6.83 0.35 4.22e-11 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; CRC cis rs514406 0.661 rs550561 chr1:53375134 C/T cg24675658 chr1:53192096 ZYG11B -0.7 -10.17 -0.49 2.57e-21 Monocyte count; CRC cis rs798554 0.731 rs2283779 chr7:2815140 G/A cg13628971 chr7:2884303 GNA12 0.42 6.19 0.32 1.82e-9 Height; CRC cis rs9916302 0.904 rs4239222 chr17:37696235 A/C cg03013999 chr17:37608204 MED1 -0.44 -6.8 -0.35 4.88e-11 Glomerular filtration rate (creatinine); CRC cis rs2243480 0.901 rs778730 chr7:65823325 T/A cg18252515 chr7:66147081 NA -1.28 -14.82 -0.63 2.09e-38 Diabetic kidney disease; CRC cis rs853679 0.517 rs4713145 chr6:28106827 T/C cg15786705 chr6:28176104 NA 0.77 9.75 0.47 6.92e-20 Depression; CRC cis rs28386778 0.797 rs4968664 chr17:61851366 C/G cg07362569 chr17:61921086 SMARCD2 0.38 5.84 0.31 1.25e-8 Prudent dietary pattern; CRC cis rs7215564 0.730 rs2316066 chr17:78659785 A/G cg09596252 chr17:78655493 RPTOR 0.53 5.66 0.3 3.26e-8 Myopia (pathological); CRC cis rs79839061 0.610 rs1564282 chr4:852313 C/T cg07828340 chr4:882639 GAK 1.19 11.11 0.52 1.43e-24 Intelligence (multi-trait analysis); CRC trans rs1900442 0.536 rs1815346 chr13:42547580 A/G cg02119577 chr21:40195074 ETS2 0.38 6.15 0.32 2.25e-9 Tuberculosis; CRC cis rs8177253 1.000 rs8177271 chr3:133482230 G/A cg01448562 chr3:133502909 NA -0.54 -9.16 -0.45 5.61e-18 Iron status biomarkers; CRC cis rs9463078 0.547 rs4714822 chr6:44742290 T/C cg25276700 chr6:44698697 NA 0.3 7.76 0.39 1.09e-13 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; CRC cis rs6543140 0.964 rs6736135 chr2:103064924 A/G cg04239558 chr2:103089729 SLC9A4 0.36 6.17 0.32 2.01e-9 Blood protein levels; CRC cis rs61774743 0.754 rs11578963 chr1:41834183 A/G cg00290994 chr1:41848739 NA -0.48 -7.21 -0.37 3.94e-12 Intelligence (multi-trait analysis); CRC cis rs9814567 1.000 rs9834755 chr3:134206845 G/A cg06541857 chr3:134203789 ANAPC13;CEP63 -0.4 -6.04 -0.32 4.25e-9 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs2739330 0.789 rs5760109 chr22:24252938 C/G cg11060661 chr22:24314208 DDT;DDTL 0.49 8.47 0.42 8.2e-16 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs4862750 0.957 rs6858853 chr4:187903412 A/C cg27532560 chr4:187881888 NA 0.58 10.64 0.51 6.62e-23 Lobe attachment (rater-scored or self-reported); CRC cis rs10504229 0.593 rs76118562 chr8:57988110 G/C cg24829409 chr8:58192753 C8orf71 -0.53 -6.22 -0.32 1.5e-9 Developmental language disorder (linguistic errors); CRC trans rs11098499 0.754 rs2036860 chr4:120248934 A/G cg25214090 chr10:38739885 LOC399744 0.53 8.37 0.42 1.72e-15 Corneal astigmatism; CRC cis rs9322193 0.923 rs10782318 chr6:150075273 A/G cg00933542 chr6:150070202 PCMT1 0.32 6.29 0.33 1.02e-9 Lung cancer; CRC cis rs7618915 0.547 rs6768697 chr3:52703615 C/T cg15147215 chr3:52552868 STAB1 -0.62 -10.31 -0.49 8.76e-22 Bipolar disorder; CRC cis rs6545883 0.931 rs12713438 chr2:61725501 G/A cg15711740 chr2:61764176 XPO1 -0.47 -6.51 -0.34 2.74e-10 Tuberculosis; CRC cis rs11690935 0.632 rs11690807 chr2:172628120 G/A cg13550731 chr2:172543902 DYNC1I2 0.67 9.99 0.48 1.04e-20 Schizophrenia; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg08931196 chr11:119205177 RNF26 -0.42 -6.38 -0.33 6.17e-10 Myopia (pathological); CRC cis rs1046896 0.553 rs9893885 chr17:80837107 C/T cg19046167 chr17:80928561 B3GNTL1 0.52 7.2 0.37 4.17e-12 Glycated hemoglobin levels; CRC cis rs13191362 1.000 rs67046187 chr6:163068532 C/A cg21926612 chr6:163149169 PACRG;PARK2 0.97 12.69 0.57 2.66e-30 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs12822507 0.783 rs10772585 chr12:12772733 T/C cg11838227 chr12:12764436 CREBL2 0.41 5.62 0.3 4.09e-8 Systemic lupus erythematosus; CRC cis rs780096 0.546 rs7563162 chr2:27631191 C/T cg17158414 chr2:27665306 KRTCAP3 -0.29 -6.26 -0.33 1.2e-9 Total body bone mineral density; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg20919306 chr17:11924526 MAP2K4 0.37 6.07 0.32 3.61e-9 Liver disease severity in Alagille syndrome; CRC cis rs11677416 0.961 rs1894399 chr2:113540177 C/T cg06156847 chr2:113672199 IL1F7 -0.39 -5.99 -0.31 5.37e-9 Response to antipsychotic treatment in schizophrenia (working memory); CRC cis rs6860806 0.507 rs156322 chr5:131653925 C/T cg11843238 chr5:131593191 PDLIM4 0.42 6.95 0.36 1.91e-11 Breast cancer; CRC cis rs11098499 1.000 rs6837898 chr4:120179154 C/T cg09307838 chr4:120376055 NA 0.64 9.87 0.48 2.78e-20 Corneal astigmatism; CRC cis rs12477438 0.748 rs6712773 chr2:99585781 A/G cg14399236 chr2:99771627 LIPT1;TSGA10 -0.74 -10.37 -0.5 5.51e-22 Chronic sinus infection; CRC cis rs2204008 0.729 rs114133083 chr12:38182923 G/C cg26384229 chr12:38710491 ALG10B -0.56 -8.25 -0.41 3.84e-15 Bladder cancer; CRC cis rs860295 0.702 rs10796943 chr1:155414729 T/C cg02153340 chr1:155202674 NA -0.58 -6.88 -0.35 3.04e-11 Body mass index; CRC cis rs61996546 0.622 rs17560758 chr15:26836402 C/T cg15066197 chr15:26874202 GABRB3 -0.39 -5.8 -0.3 1.58e-8 Response to methotrexate in juvenile idiopathic arthritis; CRC cis rs910316 0.789 rs4899552 chr14:75667921 C/A cg03030879 chr14:75389066 RPS6KL1 0.39 5.84 0.31 1.27e-8 Height; CRC cis rs12190007 0.517 rs3006183 chr6:169808263 T/C cg15038512 chr6:170123185 PHF10 -0.39 -6.05 -0.32 3.86e-9 Obesity-related traits; CRC cis rs2075371 0.527 rs1862046 chr7:134023524 T/C cg02659138 chr7:134003124 SLC35B4 0.37 5.83 0.31 1.31e-8 Mean platelet volume; CRC cis rs921968 0.565 rs6436072 chr2:219598095 C/T cg02176678 chr2:219576539 TTLL4 -0.39 -6.27 -0.33 1.12e-9 Mean corpuscular hemoglobin concentration; CRC cis rs6599388 0.803 rs11248057 chr4:906131 C/G cg08222618 chr4:941054 TMEM175 -0.44 -7.07 -0.36 9.24e-12 Parkinson's disease; CRC cis rs6732160 0.588 rs62151795 chr2:73376840 G/A cg01422370 chr2:73384389 NA 0.37 5.75 0.3 2.07e-8 Intelligence (multi-trait analysis); CRC cis rs4862750 0.872 rs13110072 chr4:187878524 A/G cg22105103 chr4:187893119 NA 0.64 11.86 0.55 2.89e-27 Lobe attachment (rater-scored or self-reported); CRC cis rs9467711 0.606 rs9348709 chr6:26360311 G/A cg16898833 chr6:26189333 HIST1H4D 0.75 6.55 0.34 2.26e-10 Autism spectrum disorder or schizophrenia; CRC cis rs10504229 0.654 rs903705 chr8:58128185 T/A cg04204079 chr8:58130323 NA -0.45 -5.78 -0.3 1.71e-8 Developmental language disorder (linguistic errors); CRC cis rs7617480 0.616 rs9873227 chr3:48773108 G/C cg07636037 chr3:49044803 WDR6 0.86 10.16 0.49 2.81e-21 Subjective well-being (multi-trait analysis);Menarche (age at onset); CRC cis rs3859192 0.599 rs2302777 chr17:38179492 A/G cg17467752 chr17:38218738 THRA -0.53 -7.75 -0.39 1.13e-13 White blood cell count; CRC cis rs10504229 0.683 rs62621195 chr8:58133964 G/A cg24829409 chr8:58192753 C8orf71 -0.55 -8.03 -0.4 1.71e-14 Developmental language disorder (linguistic errors); CRC cis rs9467603 1.000 rs13200921 chr6:25790378 T/C cg08501292 chr6:25962987 TRIM38 1.09 9.3 0.46 2.03e-18 Intelligence (multi-trait analysis); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg05001908 chr7:128045859 IMPDH1 0.44 7.35 0.38 1.61e-12 Liver disease severity in Alagille syndrome; CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg13404532 chr3:128483276 RAB7A -0.37 -6.07 -0.32 3.6e-9 Obesity-related traits; CRC trans rs61931739 0.500 rs6488221 chr12:34525671 A/G cg26384229 chr12:38710491 ALG10B 0.59 8.77 0.44 9.48e-17 Morning vs. evening chronotype; CRC trans rs11654801 0.947 rs3785544 chr17:20915515 C/T cg23759823 chr7:139672531 TBXAS1 -0.47 -6.75 -0.35 6.86e-11 Mosquito bite size; CRC cis rs514406 0.929 rs557920 chr1:53338757 C/A cg25767906 chr1:53392781 SCP2 -0.51 -8.16 -0.41 7.02e-15 Monocyte count; CRC cis rs7264396 0.887 rs6060435 chr20:34069370 C/T cg04508476 chr20:34239394 CPNE1;RBM12 0.39 6.6 0.34 1.61e-10 Total cholesterol levels; CRC cis rs7259376 0.905 rs116632927 chr19:22562520 C/T cg02657401 chr19:22469223 NA -0.33 -7.19 -0.37 4.46e-12 Menopause (age at onset); CRC trans rs17685 0.753 rs8200 chr7:75696606 C/G cg19862616 chr7:65841803 NCRNA00174 -0.97 -18.33 -0.71 3.23e-52 Coffee consumption;Coffee consumption (cups per day); CRC cis rs12760731 0.668 rs10913532 chr1:178278692 A/G cg00404053 chr1:178313656 RASAL2 0.7 8.98 0.44 2.19e-17 Obesity-related traits; CRC cis rs2243480 1.000 rs3885839 chr7:65290403 G/T cg12463550 chr7:65579703 CRCP 0.71 6.54 0.34 2.33e-10 Diabetic kidney disease; CRC cis rs854765 0.647 rs854769 chr17:18019011 A/G cg04398451 chr17:18023971 MYO15A 0.67 12.36 0.56 4.4e-29 Total body bone mineral density; CRC cis rs4308124 0.679 rs7600458 chr2:111963590 G/C cg04571233 chr2:111982156 NA -0.55 -8.2 -0.41 5.46e-15 Vitiligo; CRC cis rs4561483 0.583 rs12149833 chr16:12003723 C/T cg08843971 chr16:11963173 GSPT1 0.5 7.46 0.38 7.84e-13 Testicular germ cell tumor; CRC trans rs8123881 0.733 rs7268466 chr20:15810676 C/T cg07167098 chr12:21654695 RECQL;GOLT1B 0.57 6.06 0.32 3.77e-9 Body mass index; CRC cis rs2243480 0.908 rs55876148 chr7:65379800 G/A cg25985355 chr7:65971099 NA -0.48 -5.67 -0.3 3.12e-8 Diabetic kidney disease; CRC cis rs10504229 0.728 rs78765835 chr8:58154337 A/G cg02290350 chr8:58132656 NA -0.51 -6.57 -0.34 1.98e-10 Developmental language disorder (linguistic errors); CRC cis rs597539 0.652 rs674654 chr11:68698762 G/T cg04772025 chr11:68637568 NA 0.48 7.32 0.37 1.89e-12 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs1983170 1.000 rs597288 chr1:91999296 C/T cg21854759 chr1:92012499 NA 0.47 6.2 0.32 1.73e-9 Eosinophil percentage of white cells; CRC cis rs875971 0.660 rs62465434 chr7:66005152 A/C cg11764359 chr7:65958608 NA 0.55 8.6 0.43 3.21e-16 Aortic root size; CRC cis rs763121 0.853 rs2413546 chr22:39107001 G/A cg06022373 chr22:39101656 GTPBP1 0.78 12.18 0.56 1.98e-28 Menopause (age at onset); CRC cis rs3617 0.625 rs2240917 chr3:52851137 T/C cg07507251 chr3:52567010 NT5DC2 0.4 6.1 0.32 3e-9 Red blood cell count;Autism spectrum disorder or schizophrenia; CRC cis rs7619833 0.620 rs13085724 chr3:27258758 C/T cg02860705 chr3:27208620 NA 0.39 6.13 0.32 2.54e-9 Breast cancer; CRC cis rs2033711 0.840 rs3764533 chr19:58929194 A/G cg00825309 chr19:58991885 ZNF446 -0.52 -7.71 -0.39 1.54e-13 Uric acid clearance; CRC cis rs634534 0.561 rs14157 chr11:65769780 T/G cg17985854 chr11:65770987 BANF1;EIF1AD 0.53 8.97 0.44 2.27e-17 Sum eosinophil basophil counts;Eosinophil counts; CRC cis rs765787 0.530 rs11636018 chr15:45539137 T/C cg24006582 chr15:45444508 DUOX1 -0.57 -8.63 -0.43 2.62e-16 Uric acid levels; CRC cis rs9733 0.540 rs4971041 chr1:150537357 C/T cg17724175 chr1:150552817 MCL1 -0.54 -8.69 -0.43 1.75e-16 Tonsillectomy; CRC cis rs8014204 0.762 rs8016389 chr14:75287554 T/C cg03030879 chr14:75389066 RPS6KL1 -0.4 -6.3 -0.33 9.39e-10 Caffeine consumption; CRC cis rs992157 0.835 rs4674283 chr2:219144254 G/A cg13835894 chr2:219148914 PNKD;TMBIM1 -0.35 -6.76 -0.35 6.22e-11 Colorectal cancer; CRC cis rs995000 0.931 rs1168089 chr1:63113719 T/C cg19896129 chr1:63156450 NA -0.4 -6.23 -0.32 1.4e-9 Triglyceride levels; CRC cis rs60843830 1.000 rs7605824 chr2:280819 A/G cg00108164 chr2:264199 ACP1;SH3YL1 -0.63 -10.04 -0.48 7.43e-21 Spherical equivalent (joint analysis main effects and education interaction); CRC cis rs7737355 0.947 rs2191001 chr5:131096677 C/G cg06307176 chr5:131281290 NA 0.43 6.36 0.33 6.62e-10 Life satisfaction; CRC cis rs4242434 0.854 rs3735893 chr8:22452704 A/G cg03733263 chr8:22462867 KIAA1967 0.96 18.57 0.72 3.66e-53 Exploratory eye movement dysfunction in schizophrenia (cognitive search score); CRC cis rs17227506 0.730 rs36106719 chr8:13457693 G/C cg03566418 chr8:13424080 C8orf48 0.39 6.47 0.34 3.53e-10 Nonsyndromic cleft lip with cleft palate; CRC cis rs9733 0.596 rs6690725 chr1:150632322 T/C cg15448220 chr1:150897856 SETDB1 0.45 6.43 0.33 4.42e-10 Tonsillectomy; CRC trans rs2216228 1.000 rs16924758 chr12:22364519 C/T cg07476617 chr2:201981834 CFLAR 0.5 6.0 0.31 5.26e-9 Non-alcoholic fatty liver disease histology (lobular); CRC cis rs12477438 0.520 rs13035311 chr2:99717322 C/G cg26064155 chr2:99771622 LIPT1;TSGA10 0.83 14.73 0.63 4.68e-38 Chronic sinus infection; CRC cis rs2070488 0.636 rs2284817 chr3:38510388 A/G cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.58 8.55 0.43 4.65e-16 Electrocardiographic conduction measures; CRC cis rs4076764 0.958 rs10917748 chr1:163400377 T/C cg24596788 chr1:163392923 NA -0.68 -10.9 -0.52 7.79e-24 Motion sickness; CRC cis rs9768139 0.708 rs896781 chr7:158114114 T/C cg06219351 chr7:158114137 PTPRN2 -0.61 -9.78 -0.47 5.22e-20 Calcium levels; CRC cis rs7666738 0.830 rs62318471 chr4:98925848 G/A cg05340658 chr4:99064831 C4orf37 0.6 9.35 0.46 1.34e-18 Colonoscopy-negative controls vs population controls; CRC cis rs7107174 1.000 rs2511186 chr11:77984306 C/G cg02023728 chr11:77925099 USP35 0.54 8.26 0.41 3.49e-15 Testicular germ cell tumor; CRC cis rs10504229 1.000 rs73609760 chr8:58192170 A/G cg01721255 chr8:58191610 C8orf71 0.48 5.89 0.31 9.6e-9 Developmental language disorder (linguistic errors); CRC cis rs17767392 0.958 rs10483836 chr14:72001614 A/C cg13720639 chr14:72061746 SIPA1L1 -0.55 -6.92 -0.36 2.34e-11 Mitral valve prolapse; CRC trans rs2303319 0.504 rs62188988 chr2:162531068 T/C cg01191114 chr3:48936118 SLC25A20 -0.68 -6.16 -0.32 2.14e-9 Cognitive function; CRC cis rs11673344 0.583 rs10425719 chr19:37950798 C/G cg11669319 chr19:37771680 NA -0.41 -5.78 -0.3 1.73e-8 Obesity-related traits; CRC cis rs9914988 0.943 rs11652272 chr17:27167973 C/G cg16670446 chr17:27188758 MIR451;MIR144 0.55 8.38 0.42 1.57e-15 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs76878669 0.561 rs7117630 chr11:66154777 C/T cg18002602 chr11:66138449 SLC29A2 -0.31 -6.71 -0.35 8.36e-11 Educational attainment (years of education); CRC cis rs478304 0.593 rs4645927 chr11:65482827 C/T cg05805236 chr11:65401703 PCNXL3 -0.4 -6.21 -0.32 1.63e-9 Acne (severe); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg24725560 chr11:32605793 EIF3M 0.43 6.14 0.32 2.34e-9 Response to antipsychotic treatment; CRC cis rs709400 0.628 rs11622320 chr14:103912194 A/T cg12935359 chr14:103987150 CKB -0.5 -7.67 -0.39 2.01e-13 Body mass index; CRC trans rs9858542 0.903 rs35999162 chr3:49597230 C/G cg21582582 chr3:182698605 DCUN1D1 -0.52 -6.51 -0.34 2.79e-10 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs8060686 0.641 rs57408712 chr16:68242573 G/C cg08314208 chr16:67682810 RLTPR -0.55 -6.14 -0.32 2.34e-9 HDL cholesterol;Metabolic syndrome; CRC cis rs9549367 0.713 rs3024743 chr13:113821430 C/T cg00898013 chr13:113819073 PROZ -0.55 -8.06 -0.41 1.43e-14 Platelet distribution width; CRC cis rs1862618 0.853 rs252910 chr5:56192983 G/A cg20203395 chr5:56204925 C5orf35 -0.74 -8.3 -0.42 2.82e-15 Initial pursuit acceleration; CRC cis rs73206853 0.563 rs16940950 chr12:111136459 A/G cg12870014 chr12:110450643 ANKRD13A 0.8 9.08 0.45 1.04e-17 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC cis rs9467160 0.834 rs10946701 chr6:24453878 T/A cg20631270 chr6:24437470 GPLD1 0.46 6.3 0.33 9.53e-10 Liver enzyme levels; CRC cis rs9858542 0.951 rs1800668 chr3:49395757 G/A cg07274523 chr3:49395745 GPX1 0.46 6.23 0.32 1.46e-9 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs7726839 0.540 rs4957080 chr5:644552 A/C cg14541582 chr5:601475 NA 0.36 7.27 0.37 2.63e-12 Obesity-related traits; CRC cis rs9549367 0.756 rs9549702 chr13:113881944 T/G cg18105134 chr13:113819100 PROZ -0.74 -11.62 -0.54 2.27e-26 Platelet distribution width; CRC cis rs73200209 0.744 rs56159580 chr12:116420448 T/C cg01776926 chr12:116560359 MED13L -0.68 -7.83 -0.4 6.65e-14 Total body bone mineral density; CRC trans rs2727020 0.681 rs2866362 chr11:49379316 A/G cg11707556 chr5:10655725 ANKRD33B -0.35 -6.57 -0.34 1.96e-10 Coronary artery disease; CRC cis rs2298450 0.550 rs9977284 chr21:37654627 T/A cg02919814 chr21:37666008 DOPEY2 -0.44 -6.43 -0.33 4.4e-10 Schizophrenia; CRC cis rs7119 0.635 rs907374 chr15:77884026 C/T cg10437265 chr15:77819839 NA -0.53 -9.25 -0.45 2.83e-18 Type 2 diabetes; CRC cis rs4604732 0.631 rs10925043 chr1:247627001 G/A cg12754571 chr1:247694271 LOC148824;OR2C3 0.41 5.78 0.3 1.74e-8 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CRC cis rs4713118 0.869 rs9393851 chr6:27699581 A/T cg08798685 chr6:27730294 NA -0.42 -6.26 -0.33 1.23e-9 Parkinson's disease; CRC cis rs11628318 0.614 rs1190338 chr14:103105792 T/G cg23461800 chr14:103021989 NA -0.7 -8.03 -0.4 1.73e-14 Platelet count; CRC cis rs9910055 0.639 rs7217858 chr17:42254527 T/G cg09913183 chr17:42254507 C17orf65;ASB16 0.65 10.18 0.49 2.38e-21 Total body bone mineral density; CRC cis rs11122272 0.735 rs2486727 chr1:231539245 A/G cg06096015 chr1:231504339 EGLN1 0.39 5.84 0.31 1.28e-8 Hemoglobin concentration; CRC cis rs2857891 0.909 rs56261447 chr11:6939382 A/C cg04053776 chr11:6947353 ZNF215 0.51 6.84 0.35 3.86e-11 Response to cytadine analogues (cytosine arabinoside); CRC cis rs11764590 0.950 rs11514731 chr7:2051503 C/G cg23422044 chr7:1970798 MAD1L1 -0.57 -6.82 -0.35 4.26e-11 Neuroticism; CRC cis rs873946 0.648 rs12771651 chr10:134554482 C/A cg27286337 chr10:134555280 INPP5A 0.84 10.38 0.5 4.98e-22 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CRC cis rs6867032 1.000 rs16902321 chr5:2015148 A/G cg26168224 chr5:2018326 NA 0.97 18.69 0.72 1.23e-53 Gut microbiome composition (winter); CRC cis rs939584 1.000 rs12714414 chr2:651407 A/G cg03610516 chr2:642275 NA -0.43 -5.97 -0.31 6.25e-9 Body mass index; CRC cis rs7737355 0.947 rs6890784 chr5:130939540 T/C cg06307176 chr5:131281290 NA 0.5 7.06 0.36 1.01e-11 Life satisfaction; CRC cis rs35883536 1.000 rs871151 chr1:101123737 G/A cg14515779 chr1:101123966 NA -0.45 -8.79 -0.44 8.55e-17 Monocyte count; CRC cis rs4423214 0.650 rs2186777 chr11:71219803 C/A cg05163923 chr11:71159392 DHCR7 0.57 7.23 0.37 3.34e-12 Vitamin D levels; CRC cis rs904251 0.772 rs10692 chr6:37450914 T/C cg25019722 chr6:37503610 NA -0.41 -6.86 -0.35 3.47e-11 Cognitive performance; CRC cis rs736801 0.607 rs11739135 chr5:131733397 C/G cg00255919 chr5:131827918 IRF1 -0.35 -5.75 -0.3 2.06e-8 Breast cancer;Mosquito bite size; CRC cis rs2976388 1.000 rs2920297 chr8:143763083 A/G cg22687807 chr8:143858763 LYNX1 -0.37 -6.47 -0.34 3.46e-10 Urinary tract infection frequency; CRC cis rs1670533 1.000 rs2290411 chr4:1051077 T/C cg27284194 chr4:1044797 NA 0.51 6.23 0.33 1.39e-9 Recombination rate (females); CRC cis rs7666738 0.822 rs28512427 chr4:98919029 G/A cg17366294 chr4:99064904 C4orf37 0.43 7.14 0.37 6.09e-12 Colonoscopy-negative controls vs population controls; CRC cis rs12541635 0.639 rs10095827 chr8:106984403 A/G cg10147462 chr8:107024639 NA 0.57 9.92 0.48 1.85e-20 Age of smoking initiation; CRC cis rs4604732 0.603 rs10802513 chr1:247633919 C/T cg02104434 chr1:247694406 LOC148824;OR2C3 0.4 6.61 0.34 1.59e-10 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CRC cis rs9467711 0.591 rs13216785 chr6:26079185 C/T cg19084075 chr6:26124329 HIST1H2AC;HIST1H2BC 0.66 6.2 0.32 1.67e-9 Autism spectrum disorder or schizophrenia; CRC cis rs8078723 0.738 rs8066582 chr17:38146929 A/G cg17467752 chr17:38218738 THRA -0.57 -9.0 -0.44 1.79e-17 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); CRC cis rs344364 0.511 rs2982447 chr16:1947413 C/T cg14074117 chr16:1909714 C16orf73 -0.4 -5.63 -0.3 3.84e-8 Glomerular filtration rate in chronic kidney disease; CRC cis rs861020 1.000 rs7555285 chr1:209970355 C/G cg09163369 chr1:210001066 C1orf107 -0.49 -6.67 -0.35 1.07e-10 Orofacial clefts; CRC trans rs916888 0.738 rs199515 chr17:44856641 C/G cg10053473 chr17:62856997 LRRC37A3 0.69 8.29 0.42 2.97e-15 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs17209837 0.607 rs4148821 chr7:87079602 G/C cg00919237 chr7:87102261 ABCB4 -0.5 -6.59 -0.34 1.7e-10 Gallbladder cancer; CRC cis rs10905065 0.930 rs10737012 chr10:5746686 G/A cg11519256 chr10:5708881 ASB13 0.44 6.33 0.33 7.84e-10 Menopause (age at onset); CRC cis rs4665809 0.590 rs1049987 chr2:26413817 C/T cg08067268 chr2:26466485 HADHB;HADHA 0.68 8.55 0.43 4.67e-16 Gut microbiome composition (summer); CRC cis rs9733 0.596 rs12403255 chr1:150660412 C/T cg18016565 chr1:150552671 MCL1 0.45 6.59 0.34 1.72e-10 Tonsillectomy; CRC cis rs2806561 1.000 rs1208932 chr1:23429122 T/G cg19743168 chr1:23544995 NA -0.36 -5.67 -0.3 3.21e-8 Height; CRC cis rs6500395 1.000 rs12598514 chr16:48689319 T/C cg04672837 chr16:48644449 N4BP1 -0.44 -6.6 -0.34 1.65e-10 Response to tocilizumab in rheumatoid arthritis; CRC cis rs10504229 0.683 rs17802743 chr8:58105897 C/T cg02290350 chr8:58132656 NA -0.57 -6.64 -0.34 1.28e-10 Developmental language disorder (linguistic errors); CRC cis rs6748734 1.000 rs4675860 chr2:241840417 A/G cg16358738 chr2:241808595 AGXT -0.41 -6.0 -0.31 5.17e-9 Urinary metabolites; CRC cis rs1062746 0.557 rs35441225 chr16:87335498 C/A cg02258303 chr16:87377426 FBXO31 -0.49 -7.35 -0.38 1.63e-12 Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 2 peripheral neuropathy); CRC cis rs6681460 0.966 rs7524851 chr1:67093018 T/C cg02459107 chr1:67143332 SGIP1 0.43 7.07 0.36 9.07e-12 Presence of antiphospholipid antibodies; CRC cis rs2204008 0.837 rs11180821 chr12:38242843 A/G cg26384229 chr12:38710491 ALG10B 0.66 9.19 0.45 4.44e-18 Bladder cancer; CRC cis rs669446 0.533 rs6429638 chr1:44211010 A/G cg12908607 chr1:44402522 ARTN -0.38 -6.33 -0.33 8.09e-10 Amyotrophic lateral sclerosis (age of onset); CRC cis rs7945705 0.967 rs2568090 chr11:8849495 T/C cg21881798 chr11:8931708 C11orf17;ST5 0.56 8.35 0.42 1.92e-15 Hemoglobin concentration; CRC cis rs1862618 0.853 rs832568 chr5:56153776 G/A cg18230493 chr5:56204884 C5orf35 -0.73 -9.18 -0.45 4.8e-18 Initial pursuit acceleration; CRC cis rs2032447 0.531 rs428469 chr6:25898624 G/A cg18357526 chr6:26021779 HIST1H4A 0.6 7.5 0.38 5.83e-13 Intelligence (multi-trait analysis); CRC cis rs6912958 0.754 rs6918909 chr6:88247251 A/C cg12350822 chr6:88032061 C6orf162;GJB7 -0.32 -6.0 -0.31 5.3e-9 Monocyte percentage of white cells; CRC cis rs651907 0.535 rs12633089 chr3:101528763 C/T cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.6 7.95 0.4 3.02e-14 Colorectal cancer; CRC cis rs6502050 0.799 rs4789681 chr17:80100546 G/A cg11859384 chr17:80120422 CCDC57 -0.37 -5.85 -0.31 1.16e-8 Life satisfaction; CRC cis rs853679 0.517 rs17774663 chr6:28120898 G/A cg15786705 chr6:28176104 NA 0.78 9.83 0.48 3.57e-20 Depression; CRC trans rs2727020 0.636 rs10839275 chr11:49438962 T/A cg03929089 chr4:120376271 NA -0.87 -16.07 -0.66 2.67e-43 Coronary artery disease; CRC cis rs4862307 0.836 rs4507404 chr4:185003767 C/T cg06737308 chr4:185021514 ENPP6 -0.46 -7.39 -0.38 1.26e-12 Serum dimethylarginine levels (asymmetric/symetric ratio); CRC cis rs9292777 0.777 rs10512734 chr5:40393605 C/T cg09067459 chr5:40385259 NA 0.54 8.82 0.44 6.64e-17 Crohn's disease;Multiple sclerosis; CRC cis rs4713118 0.869 rs6902689 chr6:27709441 C/T cg06470822 chr6:28175283 NA 0.71 10.02 0.48 8.63e-21 Parkinson's disease; CRC cis rs2565722 0.622 rs57300662 chr6:161301965 A/G cg03159191 chr6:161285451 NA -0.46 -6.28 -0.33 1.07e-9 Blood protein levels; CRC cis rs1348850 0.793 rs13000048 chr2:178337089 C/A cg02961200 chr2:178257176 LOC100130691;AGPS 0.58 8.37 0.42 1.66e-15 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs10504229 0.728 rs17804720 chr8:58154565 T/C cg11062466 chr8:58055876 NA 0.45 6.11 0.32 2.74e-9 Developmental language disorder (linguistic errors); CRC cis rs7618501 0.633 rs2252833 chr3:50004209 C/T cg24308560 chr3:49941425 MST1R -0.55 -9.23 -0.45 3.27e-18 Intelligence (multi-trait analysis); CRC cis rs1519814 0.915 rs6992410 chr8:121113566 T/G cg22335954 chr8:121166405 COL14A1 -0.55 -6.23 -0.32 1.45e-9 Breast cancer; CRC cis rs12476592 0.602 rs11898615 chr2:63748284 C/A cg10828910 chr2:63850056 LOC388955 0.47 5.96 0.31 6.67e-9 Childhood ear infection; CRC cis rs1065852 0.526 rs59993856 chr22:42403980 C/T cg22189786 chr22:42395067 WBP2NL 0.43 6.39 0.33 5.61e-10 Response to serotonin reuptake inhibitors in major depressive disorder (plasma drug and metabolite levels); CRC cis rs13191362 1.000 rs73035021 chr6:163000716 C/A cg23758597 chr6:163146217 PARK2 -0.55 -6.12 -0.32 2.61e-9 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs2204008 0.666 rs67792345 chr12:38204698 T/C cg26384229 chr12:38710491 ALG10B 0.64 8.19 0.41 5.89e-15 Bladder cancer; CRC cis rs2404602 0.692 rs12594556 chr15:77165363 G/A cg23625390 chr15:77176239 SCAPER 0.46 6.53 0.34 2.56e-10 Blood metabolite levels; CRC cis rs911119 1.000 rs3827143 chr20:23619617 A/G cg16589663 chr20:23618590 CST3 0.62 8.01 0.4 2.01e-14 Chronic kidney disease; CRC cis rs1552244 0.935 rs41520445 chr3:10153141 A/C cg08888203 chr3:10149979 C3orf24 -0.7 -9.5 -0.46 4.53e-19 Alzheimer's disease; CRC cis rs10751667 0.643 rs10902238 chr11:944810 G/A cg23136738 chr11:925521 AP2A2 -0.41 -6.73 -0.35 7.76e-11 Alzheimer's disease (late onset); CRC cis rs7412746 0.611 rs36008098 chr1:150856806 G/A cg17724175 chr1:150552817 MCL1 0.43 6.5 0.34 2.96e-10 Melanoma; CRC cis rs11711311 1.000 rs9830975 chr3:113486019 A/G cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.51 -6.92 -0.36 2.41e-11 IgG glycosylation; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg14233568 chr2:65216118 SLC1A4 0.4 6.16 0.32 2.15e-9 Liver disease severity in Alagille syndrome; CRC cis rs6762 0.748 rs5030780 chr11:838110 C/T cg16425592 chr11:842748 TSPAN4;POLR2L -0.57 -8.54 -0.43 5.04e-16 Mean platelet volume; CRC cis rs9910055 0.762 rs2631299 chr17:42219773 G/T cg10896456 chr17:42255109 ASB16;C17orf65 0.45 7.31 0.37 2.04e-12 Total body bone mineral density; CRC cis rs477692 0.699 rs471357 chr10:131389373 C/G cg05714579 chr10:131428358 MGMT 0.46 6.55 0.34 2.25e-10 Response to temozolomide; CRC cis rs1799949 0.965 rs4239149 chr17:41328095 A/G cg05368731 chr17:41323189 NBR1 -0.57 -8.53 -0.43 5.56e-16 Menopause (age at onset); CRC cis rs11971779 0.715 rs55714903 chr7:139074590 T/C cg07862535 chr7:139043722 LUC7L2 0.82 10.66 0.51 5.69e-23 Diisocyanate-induced asthma; CRC trans rs875971 0.660 rs2191268 chr7:66110224 C/T cg10194655 chr12:110841920 ANAPC7 -0.39 -6.27 -0.33 1.14e-9 Aortic root size; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg17365369 chr19:52773256 ZNF766 -0.41 -6.02 -0.31 4.78e-9 Myopia (pathological); CRC cis rs28374715 0.662 rs691906 chr15:41474636 T/A cg18705301 chr15:41695430 NDUFAF1 0.85 13.08 0.58 9.14e-32 Ulcerative colitis; CRC trans rs2727020 0.688 rs4929894 chr11:49196333 G/C cg15704280 chr7:45808275 SEPT13 -0.84 -14.29 -0.62 2.17e-36 Coronary artery disease; CRC cis rs7615952 0.641 rs12487875 chr3:125787224 C/A cg06494592 chr3:125709126 NA -0.56 -6.78 -0.35 5.66e-11 Blood pressure (smoking interaction); CRC cis rs7618915 0.547 rs10780035 chr3:52764624 C/T cg18099408 chr3:52552593 STAB1 -0.44 -7.2 -0.37 4.11e-12 Bipolar disorder; CRC cis rs6582630 0.638 rs12423236 chr12:38548162 G/A cg13010199 chr12:38710504 ALG10B -0.42 -6.05 -0.32 3.97e-9 Drug-induced liver injury (flucloxacillin); CRC cis rs425277 0.606 rs12082939 chr1:2078922 C/T cg03732007 chr1:2071316 PRKCZ 0.4 6.65 0.34 1.2e-10 Height; CRC cis rs1005277 0.579 rs176838 chr10:38371899 A/T cg25427524 chr10:38739819 LOC399744 0.75 13.23 0.59 2.56e-32 Extrinsic epigenetic age acceleration; CRC cis rs11077998 0.844 rs1109123 chr17:80522391 T/C cg10255544 chr17:80519551 FOXK2 0.36 5.65 0.3 3.5e-8 Reticulocyte fraction of red cells; CRC cis rs3768617 0.624 rs34105373 chr1:183098387 T/C ch.1.3577855R chr1:183094577 LAMC1 0.64 9.73 0.47 8.05e-20 Fuchs's corneal dystrophy; CRC cis rs8103278 0.507 rs2041975 chr19:46238555 T/C cg14061069 chr19:46274453 DMPK 0.71 12.8 0.58 1.04e-30 Coronary artery disease; CRC cis rs4268898 1.000 rs10165445 chr2:24441698 C/T cg06627628 chr2:24431161 ITSN2 0.5 7.58 0.39 3.65e-13 Asthma; CRC cis rs2456568 1.000 rs2456568 chr11:93691332 A/T cg26875233 chr11:93583750 C11orf90 -0.33 -6.38 -0.33 6.15e-10 Response to serotonin reuptake inhibitors in major depressive disorder; CRC cis rs77861329 1.000 rs9857878 chr3:52109668 A/G cg08692210 chr3:52188851 WDR51A -0.84 -7.16 -0.37 5.43e-12 Macrophage inflammatory protein 1b levels; CRC cis rs9322193 0.923 rs11155674 chr6:150032247 T/C cg00933542 chr6:150070202 PCMT1 0.31 6.38 0.33 6.16e-10 Lung cancer; CRC cis rs1003719 0.654 rs764175 chr21:38517058 C/T cg10648535 chr21:38446584 PIGP;TTC3 -0.48 -6.63 -0.34 1.39e-10 Eye color traits; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg02326931 chr13:37572901 ALG5 0.48 6.03 0.32 4.37e-9 Thyroid stimulating hormone; CRC cis rs4713118 0.866 rs9468217 chr6:27726467 G/A cg25164649 chr6:28176230 NA 0.66 8.19 0.41 6.02e-15 Parkinson's disease; CRC cis rs3749237 0.595 rs1464566 chr3:49459376 T/C cg02487422 chr3:49467188 NICN1 0.41 6.71 0.35 8.55e-11 Resting heart rate; CRC cis rs2976388 1.000 rs1045531 chr8:143763547 C/A cg20041105 chr8:143859282 LYNX1 -0.32 -5.65 -0.3 3.45e-8 Urinary tract infection frequency; CRC cis rs9309711 0.666 rs11127429 chr2:3485224 T/G cg15541040 chr2:3486749 NA -0.52 -8.23 -0.41 4.52e-15 Neurofibrillary tangles; CRC cis rs7584330 0.518 rs74478860 chr2:238437364 C/G cg08992911 chr2:238395768 MLPH 0.61 6.19 0.32 1.8e-9 Prostate cancer; CRC cis rs8103278 0.507 rs4802276 chr19:46260748 T/C cg20908204 chr19:46285434 DMPK 0.38 8.34 0.42 2.02e-15 Coronary artery disease; CRC cis rs4804155 0.590 rs17766692 chr19:11342599 C/T cg00586551 chr19:11347513 LOC55908;DOCK6 0.83 8.46 0.42 8.6e-16 HDL cholesterol;Total cholesterol levels; CRC cis rs798554 0.704 rs798531 chr7:2770067 G/C cg17321639 chr7:2759063 NA -0.38 -5.68 -0.3 3.04e-8 Height; CRC cis rs4731207 0.698 rs4422720 chr7:124499402 C/G cg23710748 chr7:124431027 NA -0.38 -6.08 -0.32 3.42e-9 Cutaneous malignant melanoma; CRC cis rs4268898 0.735 rs34125395 chr2:24558242 C/T cg06627628 chr2:24431161 ITSN2 0.44 6.35 0.33 6.95e-10 Asthma; CRC cis rs2836633 0.929 rs11702165 chr21:40035313 C/T cg12884169 chr21:40033163 ERG 0.43 9.95 0.48 1.43e-20 Coronary artery disease; CRC cis rs4638749 0.677 rs4676186 chr2:108842640 T/C cg25838818 chr2:108905173 SULT1C2 -0.34 -5.72 -0.3 2.33e-8 Blood pressure; CRC cis rs7258465 0.931 rs7249020 chr19:18608147 A/G cg06953865 chr19:18549723 ISYNA1 -0.37 -5.65 -0.3 3.56e-8 Breast cancer; CRC cis rs9515201 1.000 rs9515201 chr13:111040798 A/C cg18114040 chr13:111062247 COL4A2 -0.33 -5.82 -0.31 1.43e-8 White matter hyperintensity burden; CRC cis rs7586879 0.789 rs13428763 chr2:25132855 T/G cg04586622 chr2:25135609 ADCY3 -0.58 -9.72 -0.47 8.37e-20 Body mass index; CRC cis rs6831352 1.000 rs1126670 chr4:100052733 C/A cg13256891 chr4:100009986 ADH5 0.6 8.52 0.43 5.77e-16 Alcohol dependence; CRC cis rs7647973 1.000 rs11130189 chr3:49347357 C/A cg07636037 chr3:49044803 WDR6 0.6 7.25 0.37 2.91e-12 Menarche (age at onset); CRC cis rs4919087 1.000 rs10786326 chr10:99070377 G/A cg25902810 chr10:99078978 FRAT1 0.39 5.98 0.31 5.73e-9 Monocyte count; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg10753582 chr1:170043676 KIFAP3 0.43 6.24 0.33 1.36e-9 Response to antipsychotic treatment; CRC cis rs6700896 0.931 rs79050868 chr1:66120916 G/A cg04111102 chr1:66153794 NA 0.34 5.92 0.31 8.22e-9 C-reactive protein;Mean corpuscular volume;Mean corpuscular hemoglobin; CRC cis rs2404602 0.647 rs11633869 chr15:77133322 G/T cg23625390 chr15:77176239 SCAPER 0.88 14.23 0.62 3.93e-36 Blood metabolite levels; CRC cis rs758324 0.947 rs6861174 chr5:131156129 A/G cg25547332 chr5:131281432 NA 0.39 5.69 0.3 2.79e-8 Alzheimer's disease in APOE e4- carriers; CRC trans rs3780486 0.846 rs4584234 chr9:33147479 G/A cg20290983 chr6:43655470 MRPS18A 1.14 25.06 0.81 2.91e-78 IgG glycosylation; CRC cis rs40363 0.645 rs250629 chr16:3525431 C/A cg21433313 chr16:3507492 NAT15 0.57 8.33 0.42 2.29e-15 Tuberculosis; CRC cis rs7772486 0.764 rs2265468 chr6:146218346 A/C cg13319975 chr6:146136371 FBXO30 -0.43 -6.54 -0.34 2.31e-10 Lobe attachment (rater-scored or self-reported); CRC cis rs6951245 0.529 rs76001997 chr7:1152615 C/T cg04025307 chr7:1156635 C7orf50 0.65 8.2 0.41 5.55e-15 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs2050392 0.517 rs160018 chr10:30772703 T/C cg25182066 chr10:30743637 MAP3K8 -0.6 -8.22 -0.41 4.79e-15 Inflammatory bowel disease; CRC cis rs72615157 0.634 rs2272343 chr7:99778285 A/C cg13153964 chr7:100026424 MEPCE;ZCWPW1 0.78 9.46 0.46 5.95e-19 Lung function (FEV1/FVC); CRC cis rs3806843 0.735 rs702394 chr5:140086786 A/G cg26395211 chr5:140044315 WDR55 0.38 5.62 0.3 4.01e-8 Depressive symptoms (multi-trait analysis); CRC cis rs7572644 0.640 rs4583413 chr2:28074824 C/T cg27432699 chr2:27873401 GPN1 0.45 6.1 0.32 3.03e-9 Response to carboplatin and paclitaxel in ovarian cancer (Caspase 3/7 EC50); CRC cis rs6060717 0.610 rs2590965 chr20:34613120 C/T cg04508476 chr20:34239394 CPNE1;RBM12 0.46 7.01 0.36 1.35e-11 Hip circumference adjusted for BMI; CRC cis rs11971779 0.680 rs17613690 chr7:139088401 C/T cg23387468 chr7:139079360 LUC7L2 -0.4 -6.82 -0.35 4.27e-11 Diisocyanate-induced asthma; CRC cis rs3087591 0.683 rs12602834 chr17:29637308 G/A cg24425628 chr17:29625626 OMG;NF1 0.71 13.17 0.59 4.3e-32 Hip circumference; CRC trans rs2303319 0.504 rs1449641 chr2:162619567 T/C cg12500891 chr11:57225987 NA -0.65 -6.05 -0.32 3.87e-9 Cognitive function; CRC cis rs7927771 1.000 rs7105282 chr11:47805614 C/A cg18512352 chr11:47633146 NA -0.49 -9.48 -0.46 5.08e-19 Subjective well-being; CRC cis rs2949837 0.581 rs1542819 chr7:45978059 T/C cg23193639 chr7:45961078 IGFBP3 0.4 6.66 0.34 1.14e-10 Sitting height ratio; CRC cis rs2933343 1.000 rs876756 chr3:128627623 G/A cg11901034 chr3:128598214 ACAD9 -0.51 -6.12 -0.32 2.73e-9 IgG glycosylation; CRC cis rs6570726 0.935 rs449377 chr6:145852437 C/G cg05347473 chr6:146136440 FBXO30 0.37 5.92 0.31 8.07e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs35146811 0.961 rs35991721 chr7:99728790 G/T cg03265037 chr7:99691720 MIR25;MCM7;MIR106B;MIR93 0.46 5.68 0.3 3e-8 Coronary artery disease; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg02451362 chr17:79885650 LOC92659;MAFG 0.44 6.02 0.31 4.68e-9 Anxiety disorder; CRC cis rs6427782 0.521 rs6670899 chr1:199891438 C/A cg07208853 chr1:200005219 NR5A2 0.22 5.72 0.3 2.41e-8 Menarche (age at onset); CRC cis rs9902453 0.967 rs7222685 chr17:28496430 A/T cg26525008 chr17:28256777 EFCAB5;SSH2 0.58 9.14 0.45 6.58e-18 Coffee consumption (cups per day); CRC cis rs7113874 0.569 rs10160430 chr11:8599876 G/T cg20771178 chr11:8615675 STK33 0.35 5.73 0.3 2.26e-8 Body mass index in physically active individuals;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs6502050 0.835 rs67106357 chr17:80116826 T/G cg22110888 chr17:80059540 CCDC57 0.4 6.48 0.34 3.37e-10 Life satisfaction; CRC cis rs796364 0.951 rs12463436 chr2:201061962 C/G cg25936922 chr2:200820526 C2orf60;C2orf47 0.53 6.03 0.32 4.39e-9 Schizophrenia; CRC cis rs1799949 0.930 rs35292991 chr17:41334016 C/A cg01879757 chr17:41196368 BRCA1 -0.44 -6.58 -0.34 1.87e-10 Menopause (age at onset); CRC trans rs7615952 0.512 rs4679430 chr3:125357893 T/C cg03844506 chr4:4109441 NA -0.51 -7.57 -0.39 3.88e-13 Blood pressure (smoking interaction); CRC cis rs2303745 0.589 rs6512179 chr19:17399105 T/C cg02221750 chr19:17393354 ANKLE1 -0.46 -6.79 -0.35 5.17e-11 Systemic lupus erythematosus; CRC cis rs2075371 0.965 rs1862049 chr7:133978344 A/T cg20476274 chr7:133979776 SLC35B4 0.82 15.15 0.64 1.05e-39 Mean platelet volume; CRC cis rs9910055 0.529 rs170637 chr17:42186868 C/T cg09913183 chr17:42254507 C17orf65;ASB16 -0.51 -6.98 -0.36 1.61e-11 Total body bone mineral density; CRC cis rs9488822 0.702 rs6909746 chr6:116352750 C/T cg15226275 chr6:116381976 FRK 0.3 8.69 0.43 1.78e-16 Cholesterol, total;LDL cholesterol; CRC cis rs1865721 0.804 rs7243462 chr18:73147998 A/T cg26385618 chr18:73139727 C18orf62 -0.41 -5.7 -0.3 2.61e-8 Intelligence; CRC cis rs2249694 0.520 rs7095996 chr10:135328948 G/A cg20169779 chr10:135381914 SYCE1 -0.55 -7.68 -0.39 1.85e-13 Obesity-related traits; CRC cis rs9393692 0.676 rs1543681 chr6:26187783 G/T cg00631329 chr6:26305371 NA -0.56 -10.05 -0.48 6.82e-21 Educational attainment; CRC cis rs12545109 0.879 rs2576588 chr8:57381627 G/A cg09654669 chr8:57350985 NA -0.43 -6.77 -0.35 5.89e-11 Obesity-related traits; CRC cis rs7618501 1.000 rs1049256 chr3:49763338 T/C cg24308560 chr3:49941425 MST1R 0.44 6.94 0.36 2.05e-11 Intelligence (multi-trait analysis); CRC cis rs1572438 0.760 rs7766714 chr6:869519 C/T cg13447295 chr6:887704 NA -0.49 -7.11 -0.36 7.39e-12 Aging; CRC cis rs9287719 0.967 rs7605461 chr2:10738134 G/A cg00105475 chr2:10696890 NA 0.45 7.3 0.37 2.19e-12 Prostate cancer; CRC cis rs4819052 0.851 rs2330011 chr21:46658498 G/A cg19498844 chr21:46707878 POFUT2;LOC642852 0.7 10.19 0.49 2.2e-21 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs116979167 0.575 rs67661063 chr7:105187259 T/G cg02135003 chr7:105160482 PUS7 -0.54 -8.33 -0.42 2.23e-15 Bipolar disorder (body mass index interaction); CRC cis rs10875746 0.859 rs4760622 chr12:48591960 C/A cg26205652 chr12:48591994 NA 0.47 5.92 0.31 8.15e-9 Longevity (90 years and older); CRC cis rs7591163 1.000 rs1039665 chr2:228717392 A/G cg01216370 chr2:228736459 WDR69 -0.45 -5.69 -0.3 2.8e-8 Blood pressure; CRC cis rs13108904 0.901 rs2293634 chr4:1291711 T/G cg21620606 chr4:1342894 KIAA1530 0.35 6.15 0.32 2.19e-9 Obesity-related traits; CRC cis rs10242455 0.557 rs57830676 chr7:99281363 C/T cg18809830 chr7:99032528 PTCD1 -0.99 -7.58 -0.39 3.64e-13 Blood metabolite levels; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg10355997 chr15:50647554 GABPB1;FLJ10038;LOC100129387 0.43 6.16 0.32 2.08e-9 Response to antipsychotic treatment; CRC trans rs7824557 0.507 rs7010590 chr8:11062882 C/T cg06636001 chr8:8085503 FLJ10661 0.55 8.31 0.42 2.62e-15 Retinal vascular caliber; CRC cis rs60871478 0.786 rs12536056 chr7:831351 T/A cg13844804 chr7:814759 HEATR2 -0.65 -7.39 -0.38 1.25e-12 Cerebrospinal P-tau181p levels; CRC cis rs1448094 0.512 rs7303330 chr12:86255123 G/A cg02569458 chr12:86230093 RASSF9 0.43 7.37 0.38 1.35e-12 Major depressive disorder; CRC cis rs1950626 0.833 rs34463495 chr14:101411186 A/C cg02351406 chr14:101447389 SNORD114-20;SNORD114-21 0.95 16.09 0.66 2.16e-43 Pelvic organ prolapse (moderate/severe); CRC cis rs1580019 0.563 rs13244332 chr7:32537679 G/A cg14728415 chr7:32535168 LSM5;AVL9 0.48 6.9 0.36 2.68e-11 Cognitive ability; CRC cis rs12249377 0.519 rs12259060 chr10:92579949 A/G cg14313238 chr10:92632228 RPP30 0.48 6.58 0.34 1.81e-10 White matter microstructure (global fractional anisotropy); CRC trans rs6951245 0.744 rs10265736 chr7:1172465 C/T cg13565492 chr6:43139072 SRF -0.74 -8.26 -0.41 3.58e-15 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs9549260 0.876 rs9549258 chr13:41248026 T/C cg21288729 chr13:41239152 FOXO1 0.49 6.19 0.32 1.84e-9 Red blood cell count; CRC trans rs1814175 0.676 rs11040647 chr11:49935947 A/C cg03929089 chr4:120376271 NA -0.91 -16.07 -0.66 2.65e-43 Height; CRC cis rs798554 0.683 rs1636264 chr7:2864586 G/T cg19346786 chr7:2764209 NA -0.37 -6.71 -0.35 8.64e-11 Height; CRC cis rs72945132 0.825 rs7950280 chr11:70213455 G/T cg00319359 chr11:70116639 PPFIA1 0.55 5.85 0.31 1.2e-8 Coronary artery disease; CRC cis rs736408 0.609 rs2230535 chr3:52800284 T/C cg15147215 chr3:52552868 STAB1 -0.63 -10.27 -0.49 1.16e-21 Bipolar disorder; CRC cis rs780096 0.565 rs8179252 chr2:27746832 A/C cg12000995 chr2:27665139 KRTCAP3 -0.3 -6.33 -0.33 8.1e-10 Total body bone mineral density; CRC cis rs34172651 0.837 rs12596793 chr16:24823667 C/G cg00339695 chr16:24857497 SLC5A11 0.25 5.95 0.31 7.02e-9 Intelligence (multi-trait analysis); CRC cis rs524023 0.958 rs12802649 chr11:64359627 C/T cg14139581 chr11:64358342 SLC22A12 -0.39 -6.19 -0.32 1.81e-9 Urate levels in obese individuals; CRC cis rs2180341 0.595 rs7771391 chr6:127749656 C/G cg24812749 chr6:127587940 RNF146 0.56 7.48 0.38 6.66e-13 Breast cancer; CRC cis rs6988985 0.818 rs7463212 chr8:143991858 A/T cg10324643 chr8:143916377 GML -0.4 -6.95 -0.36 1.94e-11 Plasma androstenedione levels in resected early stage-receptor positive breast cancer; CRC cis rs2408955 0.522 rs2051851 chr12:48485940 G/C cg00601486 chr12:48723148 H1FNT -0.34 -6.67 -0.35 1.09e-10 Glycated hemoglobin levels; CRC trans rs4332037 0.586 rs62442944 chr7:2015047 T/G cg11693508 chr17:37793320 STARD3 0.64 7.62 0.39 2.79e-13 Bipolar disorder; CRC cis rs9916302 0.851 rs7225096 chr17:37664443 T/C cg00129232 chr17:37814104 STARD3 -0.55 -8.16 -0.41 6.96e-15 Glomerular filtration rate (creatinine); CRC cis rs11190604 0.943 rs9420792 chr10:102258439 C/T cg07080220 chr10:102295463 HIF1AN 0.48 5.88 0.31 9.89e-9 Palmitoleic acid (16:1n-7) levels; CRC cis rs703842 0.532 rs238516 chr12:58117355 T/C cg18357645 chr12:58087776 OS9 0.5 6.83 0.35 4.06e-11 Multiple sclerosis; CRC cis rs6963495 0.745 rs55906043 chr7:105165367 T/G cg13798780 chr7:105162888 PUS7 0.69 8.2 0.41 5.36e-15 Bipolar disorder (body mass index interaction); CRC cis rs2019137 0.836 rs4848318 chr2:113953952 T/C cg21610815 chr2:113994035 PAX8;LOC654433;LOC440839 -0.45 -6.42 -0.33 4.82e-10 Lymphocyte counts; CRC cis rs9649465 0.561 rs631445 chr7:123413707 C/T cg03229431 chr7:123269106 ASB15 -0.58 -9.4 -0.46 9.41e-19 Migraine; CRC cis rs4555082 0.834 rs2816631 chr14:105739477 G/A cg18132624 chr14:105716052 BTBD6;BRF1 -0.51 -8.28 -0.42 3.19e-15 Mean platelet volume;Platelet distribution width; CRC trans rs208520 0.690 rs207094 chr6:66799009 G/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.07 -15.42 -0.65 9.24e-41 Exhaled nitric oxide output; CRC cis rs4731207 0.533 rs1481326 chr7:124625984 G/A cg23710748 chr7:124431027 NA -0.39 -6.24 -0.33 1.35e-9 Cutaneous malignant melanoma; CRC cis rs2243480 1.000 rs10950032 chr7:65738591 C/A cg12463550 chr7:65579703 CRCP -0.68 -6.07 -0.32 3.43e-9 Diabetic kidney disease; CRC cis rs2243480 1.000 rs10807702 chr7:65767843 C/T cg25985355 chr7:65971099 NA -0.52 -5.97 -0.31 6.09e-9 Diabetic kidney disease; CRC cis rs4727027 0.865 rs62505077 chr7:148849656 T/A cg12479418 chr7:148823350 ZNF425;ZNF398 0.43 5.84 0.31 1.26e-8 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC cis rs1865760 0.929 rs2876693 chr6:25954434 C/G cg17691542 chr6:26056736 HIST1H1C 0.55 8.26 0.41 3.66e-15 Height; CRC cis rs9292777 0.720 rs12514415 chr5:40435036 C/T cg09067459 chr5:40385259 NA -0.53 -8.63 -0.43 2.76e-16 Crohn's disease;Multiple sclerosis; CRC cis rs12497850 0.931 rs9311434 chr3:48884147 T/C cg07636037 chr3:49044803 WDR6 1.03 18.4 0.71 1.66e-52 Parkinson's disease; CRC cis rs9611565 0.512 rs6002474 chr22:42168181 A/G cg06634786 chr22:41940651 POLR3H 0.68 7.52 0.38 5.14e-13 Vitiligo; CRC cis rs1348850 0.645 rs11887886 chr2:178425730 C/T cg27490568 chr2:178487706 NA 0.5 6.38 0.33 6.01e-10 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC trans rs11098499 0.697 rs28655325 chr4:120372999 A/G cg25214090 chr10:38739885 LOC399744 0.66 10.47 0.5 2.41e-22 Corneal astigmatism; CRC cis rs736408 0.522 rs998909 chr3:52805093 A/G cg15147215 chr3:52552868 STAB1 -0.62 -10.56 -0.5 1.25e-22 Bipolar disorder; CRC cis rs79387448 0.701 rs11465596 chr2:102987093 C/A cg00507830 chr2:103233733 NA 0.59 5.89 0.31 9.5e-9 Gut microbiota (bacterial taxa); CRC cis rs4555082 0.872 rs7153832 chr14:105730563 G/T cg18132624 chr14:105716052 BTBD6;BRF1 -0.43 -7.09 -0.36 8e-12 Mean platelet volume;Platelet distribution width; CRC cis rs3820068 0.705 rs927206 chr1:15893338 C/T cg27534772 chr1:16042836 PLEKHM2 0.43 7.12 0.37 6.95e-12 Systolic blood pressure; CRC cis rs7264396 0.747 rs2425158 chr20:34419664 T/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.6 -10.52 -0.5 1.71e-22 Total cholesterol levels; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg04252616 chr1:149646781 NA -0.38 -6.37 -0.33 6.44e-10 Liver disease severity in Alagille syndrome; CRC cis rs9814567 0.762 rs13079012 chr3:134247706 A/C cg06109529 chr3:134205091 CEP63;ANAPC13 0.7 8.79 0.44 8.7e-17 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs950169 0.800 rs34302901 chr15:85110943 C/G cg11189052 chr15:85197271 WDR73 0.63 9.8 0.48 4.5e-20 Schizophrenia; CRC cis rs910316 0.692 rs7156586 chr14:75506230 A/T cg03030879 chr14:75389066 RPS6KL1 -0.57 -8.48 -0.42 7.52e-16 Height; CRC cis rs11785400 0.793 rs35985277 chr8:143736137 C/T cg24634471 chr8:143751801 JRK 0.48 6.52 0.34 2.61e-10 Schizophrenia; CRC cis rs2806561 0.606 rs218341 chr1:23294153 G/C cg12483005 chr1:23474871 LUZP1 0.5 7.4 0.38 1.14e-12 Height; CRC cis rs10128264 0.902 rs1250583 chr10:80975004 A/G cg20744163 chr10:80999841 ZMIZ1 0.44 7.87 0.4 5.24e-14 Response to methotrexate in juvenile idiopathic arthritis; CRC cis rs6089584 0.888 rs2181590 chr20:60622843 T/C cg06108461 chr20:60628389 TAF4 -0.93 -16.42 -0.67 1.17e-44 Body mass index; CRC cis rs6951245 0.706 rs28685743 chr7:1197736 C/T cg03188948 chr7:1209495 NA 0.71 7.93 0.4 3.48e-14 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs1005277 0.602 rs1780141 chr10:38504299 T/C cg17219203 chr10:38645113 HSD17B7P2 -0.41 -5.93 -0.31 7.61e-9 Extrinsic epigenetic age acceleration; CRC cis rs4713118 0.666 rs4140646 chr6:27738801 G/A cg25164649 chr6:28176230 NA 0.7 7.91 0.4 3.86e-14 Parkinson's disease; CRC cis rs1707322 1.000 rs4641257 chr1:46353589 G/A cg03146154 chr1:46216737 IPP 0.51 7.1 0.36 7.52e-12 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs875971 0.545 rs1267814 chr7:66044409 G/A cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.57 -7.28 -0.37 2.43e-12 Aortic root size; CRC cis rs10540 1.000 rs71487292 chr11:486076 G/A cg15790184 chr11:494944 RNH1 0.62 5.83 0.31 1.36e-8 Body mass index; CRC cis rs763121 0.853 rs5750662 chr22:39072472 G/A cg06544989 chr22:39130855 UNC84B 0.45 6.9 0.36 2.7e-11 Menopause (age at onset); CRC cis rs9911578 1.000 rs6503870 chr17:56659018 C/T cg05425664 chr17:57184151 TRIM37 -0.51 -8.18 -0.41 6.28e-15 Intelligence (multi-trait analysis); CRC cis rs7523050 0.643 rs35520362 chr1:109419841 C/T cg08274380 chr1:109419600 GPSM2 0.88 7.66 0.39 2.07e-13 Fat distribution (HIV); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg27309920 chr12:6798957 ZNF384 0.42 6.19 0.32 1.78e-9 Intelligence (multi-trait analysis); CRC trans rs6500957 0.920 rs17648524 chr16:7459683 C/G cg19584864 chr3:150127772 TSC22D2 0.42 6.02 0.31 4.63e-9 Spherical equivalent (joint analysis main effects and education interaction); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg09408520 chr2:157188965 NR4A2 0.44 6.2 0.32 1.73e-9 Response to antipsychotic treatment; CRC cis rs4665809 1.000 rs4233708 chr2:26291345 C/T cg25036284 chr2:26402008 FAM59B -0.45 -5.94 -0.31 7.45e-9 Gut microbiome composition (summer); CRC cis rs780096 0.546 rs1528533 chr2:27595756 G/C cg02592271 chr2:27665507 KRTCAP3 -0.27 -6.28 -0.33 1.08e-9 Total body bone mineral density; CRC cis rs1218582 0.772 rs1109815 chr1:154909268 A/G cg16680214 chr1:154839983 KCNN3 -0.45 -8.83 -0.44 6.25e-17 Prostate cancer; CRC cis rs1552244 0.882 rs17050672 chr3:10025463 G/A cg08888203 chr3:10149979 C3orf24 0.59 7.24 0.37 3.22e-12 Alzheimer's disease; CRC cis rs7312933 0.558 rs1796381 chr12:42842475 C/T cg11827402 chr12:42719852 PPHLN1;ZCRB1 0.64 9.73 0.47 7.98e-20 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CRC cis rs889312 0.500 rs252905 chr5:56118875 C/T cg20203395 chr5:56204925 C5orf35 -0.44 -6.28 -0.33 1.07e-9 Breast cancer;Breast cancer (early onset); CRC cis rs875971 0.545 rs4441996 chr7:65588220 T/C cg11764359 chr7:65958608 NA -0.46 -5.86 -0.31 1.15e-8 Aortic root size; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg26402253 chr7:87849886 SRI 0.52 6.83 0.35 4.21e-11 Thyroid stimulating hormone; CRC cis rs7429990 0.965 rs11707679 chr3:47956506 T/C cg11946769 chr3:48343235 NME6 0.49 6.19 0.32 1.8e-9 Educational attainment (years of education); CRC cis rs950027 0.620 rs35861938 chr15:45637343 T/C cg10760299 chr15:45669010 GATM 0.36 5.82 0.31 1.42e-8 Response to fenofibrate (adiponectin levels); CRC cis rs4665809 0.938 rs35844686 chr2:26304949 A/G cg26119090 chr2:26468346 HADHA;HADHB 0.64 7.35 0.38 1.6e-12 Gut microbiome composition (summer); CRC cis rs9912789 0.807 rs9896850 chr17:79191726 C/T cg25342872 chr17:79175132 AZI1 -0.46 -8.19 -0.41 5.67e-15 Frontotemporal dementia; CRC cis rs910316 1.000 rs12589376 chr14:75561152 C/T cg11812906 chr14:75593930 NEK9 0.61 9.64 0.47 1.5700000000000001e-19 Height; CRC cis rs28386778 0.897 rs8079818 chr17:61824667 C/G cg25654072 chr17:61904446 PSMC5;FTSJ3 0.73 11.32 0.53 2.54e-25 Prudent dietary pattern; CRC cis rs62408225 1.000 rs6454805 chr6:90986353 A/G cg06866423 chr6:90926672 BACH2 0.48 7.94 0.4 3.28e-14 Eosinophil counts;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC cis rs9768139 0.708 rs10234067 chr7:158114542 C/T cg06219351 chr7:158114137 PTPRN2 -0.6 -9.53 -0.47 3.61e-19 Calcium levels; CRC cis rs4481887 0.741 rs6587462 chr1:248539094 C/T cg26353448 chr1:248524236 OR2T4 0.32 6.15 0.32 2.26e-9 Common traits (Other); CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg23791442 chr22:43010704 POLDIP3;RNU12 0.46 6.46 0.34 3.66e-10 Anxiety disorder; CRC cis rs698833 0.501 rs12473699 chr2:44507673 G/A cg04920474 chr2:44395004 PPM1B 0.44 6.67 0.35 1.09e-10 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; CRC cis rs4363385 0.747 rs1415970 chr1:152965741 G/C cg25856811 chr1:152973957 SPRR3 -0.26 -7.27 -0.37 2.72e-12 Inflammatory skin disease; CRC cis rs735396 0.770 rs2259820 chr12:121435342 C/T cg02403541 chr12:121454288 C12orf43 0.49 7.23 0.37 3.36e-12 N-glycan levels; CRC cis rs6543140 0.964 rs4851592 chr2:103087641 C/T cg04239558 chr2:103089729 SLC9A4 0.37 6.59 0.34 1.77e-10 Blood protein levels; CRC cis rs9372498 0.536 rs72952793 chr6:118892979 T/A cg24463073 chr6:118973353 C6orf204 0.55 7.16 0.37 5.24e-12 Diastolic blood pressure; CRC cis rs4766646 0.619 rs4766639 chr12:110298925 A/G cg01252219 chr12:110302105 GLTP 0.41 6.26 0.33 1.17e-9 Metabolite levels (MHPG); CRC trans rs916888 0.821 rs199525 chr17:44847834 T/G cg22433210 chr17:43662623 NA 1.03 10.45 0.5 2.99e-22 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs861020 0.630 rs628300 chr1:209998298 C/T cg05527609 chr1:210001259 C1orf107 0.86 11.66 0.54 1.6e-26 Orofacial clefts; CRC cis rs9905704 0.624 rs8080071 chr17:57093825 C/T cg12560992 chr17:57184187 TRIM37 -0.65 -9.93 -0.48 1.75e-20 Testicular germ cell tumor; CRC cis rs1448094 0.511 rs17279464 chr12:86164473 C/T cg00310523 chr12:86230176 RASSF9 0.37 5.93 0.31 7.85e-9 Major depressive disorder; CRC cis rs17826219 0.706 rs73271850 chr17:29142140 A/G cg01831904 chr17:28903510 LRRC37B2 -0.63 -6.5 -0.34 3.04e-10 Body mass index; CRC cis rs4889855 0.545 rs61171555 chr17:78465975 T/G cg16591659 chr17:78472290 NA -0.58 -7.38 -0.38 1.33e-12 Fractional excretion of uric acid; CRC cis rs832540 0.898 rs170732 chr5:56251777 C/T cg18230493 chr5:56204884 C5orf35 -0.39 -6.05 -0.32 3.93e-9 Coronary artery disease; CRC cis rs6951245 1.000 rs79327308 chr7:1108141 A/C cg21664854 chr7:1097933 C7orf50;GPR146 0.78 8.89 0.44 4.21e-17 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs10504229 0.728 rs1495867 chr8:58155500 G/T cg11062466 chr8:58055876 NA 0.45 6.11 0.32 2.74e-9 Developmental language disorder (linguistic errors); CRC cis rs7845219 0.544 rs4735332 chr8:95923660 C/T cg16049864 chr8:95962084 TP53INP1 -0.44 -6.79 -0.35 5.32e-11 Type 2 diabetes; CRC cis rs740160 0.558 rs17161669 chr7:98908663 G/A cg24650262 chr7:98904301 NA 0.55 5.8 0.3 1.56e-8 Dehydroepiandrosterone sulphate levels; CRC cis rs200986 1 rs200986 chr6:27824766 G/C cg15845792 chr6:28175446 NA 0.74 10.71 0.51 3.65e-23 Autism spectrum disorder or schizophrenia; CRC cis rs2732480 0.577 rs2634693 chr12:48706498 C/T cg21466736 chr12:48725269 NA -0.61 -9.04 -0.45 1.34e-17 Hemoglobin concentration;Red blood cell count;Hematocrit; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg08449531 chr17:48610095 EPN3 0.42 6.06 0.32 3.75e-9 Response to antipsychotic treatment; CRC cis rs7524258 0.778 rs12028181 chr1:7315085 C/T cg07173049 chr1:7289937 CAMTA1 -0.51 -8.32 -0.42 2.33e-15 Tourette's syndrome or obsessive-compulsive disorder; CRC cis rs861020 0.959 rs658860 chr1:209990549 C/T cg09163369 chr1:210001066 C1orf107 0.6 7.74 0.39 1.26e-13 Orofacial clefts; CRC cis rs561341 0.739 rs9906455 chr17:30215669 G/A cg00745463 chr17:30367425 LRRC37B 0.58 7.61 0.39 2.87e-13 Hip circumference adjusted for BMI; CRC cis rs4253772 0.591 rs9615348 chr22:46729338 C/G cg24881330 chr22:46731750 TRMU 0.66 5.72 0.3 2.36e-8 LDL cholesterol;Cholesterol, total; CRC cis rs13118159 0.742 rs34947293 chr4:1335034 T/C cg16405210 chr4:1374714 KIAA1530 -0.44 -6.2 -0.32 1.71e-9 Longevity; CRC cis rs2050392 0.624 rs303447 chr10:30728464 T/C cg25182066 chr10:30743637 MAP3K8 -0.45 -5.99 -0.31 5.55e-9 Inflammatory bowel disease; CRC trans rs6472235 0.837 rs28402886 chr8:66927891 G/A cg07884673 chr3:53033167 SFMBT1 -0.45 -6.03 -0.32 4.47e-9 Myopia (pathological);Plateletcrit; CRC cis rs853679 0.517 rs1340004 chr6:28103691 C/T cg18032046 chr6:28092343 ZSCAN16 -0.51 -5.92 -0.31 7.94e-9 Depression; CRC cis rs2535633 0.631 rs2581803 chr3:52994981 G/A cg05573699 chr3:52720067 GNL3;PBRM1 0.4 5.77 0.3 1.79e-8 Body mass index; CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg12679980 chr5:43557583 PAIP1 0.38 6.17 0.32 1.99e-9 Obesity-related traits; CRC cis rs6496044 0.568 rs6496066 chr15:86075462 A/C cg17133734 chr15:86042851 AKAP13 0.4 6.49 0.34 3.21e-10 Interstitial lung disease; CRC cis rs270601 0.770 rs4361510 chr5:131599647 C/T cg27615366 chr5:131592974 PDLIM4 0.34 6.48 0.34 3.38e-10 Acylcarnitine levels; CRC cis rs9322193 0.926 rs9689036 chr6:150101699 T/C cg07701084 chr6:150067640 NUP43 0.47 6.72 0.35 8.19e-11 Lung cancer; CRC cis rs9487051 0.676 rs7753697 chr6:109593292 A/G cg01475377 chr6:109611718 NA -0.37 -6.58 -0.34 1.85e-10 Reticulocyte fraction of red cells; CRC cis rs7811142 0.720 rs7795656 chr7:99950297 A/T cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.13 16.6 0.68 2.15e-45 Platelet count; CRC cis rs6570726 0.791 rs6912079 chr6:145894949 G/A cg23711669 chr6:146136114 FBXO30 0.78 13.54 0.6 1.63e-33 Lobe attachment (rater-scored or self-reported); CRC cis rs2180341 0.596 rs12215298 chr6:127676833 C/T cg27446573 chr6:127587934 RNF146 0.67 9.93 0.48 1.68e-20 Breast cancer; CRC cis rs8177253 0.828 rs8177259 chr3:133480388 T/C cg16262614 chr3:133464971 TF 0.33 5.91 0.31 8.53e-9 Iron status biomarkers; CRC cis rs9311676 0.632 rs7610312 chr3:58374029 A/G cg06643156 chr3:58380774 PXK 0.41 6.33 0.33 7.82e-10 Systemic lupus erythematosus; CRC cis rs4332037 1.000 rs4332037 chr7:1950809 C/T cg02421172 chr7:1938701 MAD1L1 0.43 6.1 0.32 3.06e-9 Bipolar disorder; CRC trans rs116095464 0.558 rs6555052 chr5:224268 G/A cg00938859 chr5:1591904 SDHAP3 0.7 7.63 0.39 2.58e-13 Breast cancer; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg16711694 chr5:34656625 RAI14 -0.4 -6.23 -0.32 1.46e-9 Myopia (pathological); CRC cis rs10751667 0.643 rs7396407 chr11:929374 A/T cg06064525 chr11:970664 AP2A2 -0.33 -6.65 -0.34 1.25e-10 Alzheimer's disease (late onset); CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg04136173 chr3:38065951 PLCD1 -0.43 -6.45 -0.34 4.1e-10 Myopia (pathological); CRC cis rs9611565 0.512 rs6519289 chr22:42170432 A/C cg06634786 chr22:41940651 POLR3H 0.68 7.47 0.38 7.35e-13 Vitiligo; CRC cis rs8031584 0.679 rs34017474 chr15:31230611 T/C cg19680485 chr15:31195859 MTMR15 -0.41 -5.87 -0.31 1.08e-8 Huntington's disease progression; CRC cis rs8180040 1.000 rs2302278 chr3:47361082 G/T cg27129171 chr3:47204927 SETD2 -0.56 -8.7 -0.43 1.64e-16 Colorectal cancer; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg08086906 chr16:86588932 MTHFSD;FLJ30679 0.45 6.66 0.34 1.17e-10 Response to antipsychotic treatment; CRC cis rs4692589 1.000 rs7688417 chr4:170938732 C/T cg19918862 chr4:170955249 NA 0.39 6.34 0.33 7.47e-10 Anxiety disorder; CRC trans rs116095464 0.867 rs7726582 chr5:215349 C/G cg00938859 chr5:1591904 SDHAP3 0.63 6.79 0.35 5.31e-11 Breast cancer; CRC cis rs35110281 0.720 rs162394 chr21:44943550 C/G cg04455712 chr21:45112962 RRP1B -0.42 -8.12 -0.41 9.58e-15 Mean corpuscular volume; CRC cis rs4237845 0.742 rs6650219 chr12:58289100 T/C cg02175503 chr12:58329896 NA 0.59 8.37 0.42 1.73e-15 Intelligence (multi-trait analysis); CRC cis rs11997175 0.583 rs34540455 chr8:33799300 C/T cg04338863 chr8:33670619 NA 0.41 6.11 0.32 2.76e-9 Body mass index; CRC cis rs5769765 0.908 rs9616396 chr22:50317825 T/C cg02269571 chr22:50332266 NA -0.62 -7.87 -0.4 5.21e-14 Schizophrenia; CRC cis rs7666738 0.830 rs9884501 chr4:98893721 A/C cg05340658 chr4:99064831 C4orf37 0.56 8.37 0.42 1.62e-15 Colonoscopy-negative controls vs population controls; CRC cis rs1799949 0.965 rs9646413 chr17:41426157 A/G cg05368731 chr17:41323189 NBR1 0.64 9.69 0.47 1.05e-19 Menopause (age at onset); CRC cis rs3540 0.597 rs4620932 chr15:91036569 G/A cg22089800 chr15:90895588 ZNF774 0.55 8.95 0.44 2.65e-17 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; CRC cis rs6684514 1.000 rs12027741 chr1:156248148 T/G cg16558208 chr1:156270281 VHLL 0.59 9.2 0.45 4.08e-18 Mean corpuscular hemoglobin concentration;Glycated hemoglobin levels; CRC cis rs2153535 0.601 rs6906170 chr6:8543128 T/A cg07606381 chr6:8435919 SLC35B3 0.67 11.11 0.52 1.5e-24 Motion sickness; CRC cis rs9467711 0.591 rs13192365 chr6:25993968 T/C cg08501292 chr6:25962987 TRIM38 0.84 7.76 0.39 1.1e-13 Autism spectrum disorder or schizophrenia; CRC cis rs25422 0.887 rs9481844 chr6:118990941 G/A cg18833306 chr6:118973337 C6orf204 0.47 6.82 0.35 4.37e-11 Renal cell carcinoma; CRC cis rs3750082 0.852 rs6462425 chr7:32898595 C/A cg05721444 chr7:32995514 FKBP9 0.48 7.47 0.38 7.45e-13 Glomerular filtration rate (creatinine); CRC cis rs34779708 0.966 rs4934735 chr10:35496730 C/T cg03585969 chr10:35415529 CREM -0.54 -7.33 -0.37 1.76e-12 Inflammatory bowel disease;Crohn's disease; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg19017420 chr11:64781299 ARL2 0.45 6.46 0.34 3.82e-10 Intelligence (multi-trait analysis); CRC cis rs9322193 0.924 rs9498382 chr6:149932118 A/G cg05861140 chr6:150128134 PCMT1 -0.36 -5.92 -0.31 8.15e-9 Lung cancer; CRC cis rs9287719 0.967 rs6432112 chr2:10744874 A/G cg00105475 chr2:10696890 NA -0.47 -7.5 -0.38 6.04e-13 Prostate cancer; CRC cis rs8180040 0.577 rs12493425 chr3:47176946 T/G cg10298567 chr3:47292165 KIF9 -0.39 -6.12 -0.32 2.7e-9 Colorectal cancer; CRC cis rs9837602 1.000 rs6790877 chr3:99779658 C/T cg07805332 chr3:99536008 MIR548G;C3orf26 -0.48 -6.31 -0.33 8.91e-10 Breast cancer; CRC cis rs3096299 0.632 rs8051537 chr16:89544384 T/A cg01788221 chr16:89496183 ANKRD11 -0.39 -5.87 -0.31 1.06e-8 Multiple myeloma (IgH translocation); CRC cis rs7552404 1.000 rs7534754 chr1:76185308 G/A cg22875332 chr1:76189707 ACADM 0.69 9.38 0.46 1.15e-18 Blood metabolite levels;Acylcarnitine levels; CRC cis rs10256972 0.616 rs6463001 chr7:1108272 A/C cg03188948 chr7:1209495 NA 0.4 6.06 0.32 3.78e-9 Longevity;Endometriosis; CRC cis rs2243480 1.000 rs2177703 chr7:65391717 C/A cg18252515 chr7:66147081 NA -1.08 -12.66 -0.57 3.44e-30 Diabetic kidney disease; CRC trans rs8002861 0.967 rs2325071 chr13:44476793 T/C cg17145862 chr1:211918768 LPGAT1 0.77 15.53 0.65 3.57e-41 Leprosy; CRC cis rs7412746 0.658 rs2272214 chr1:150931462 C/T cg10589385 chr1:150898437 SETDB1 0.32 6.77 0.35 5.94e-11 Melanoma; CRC cis rs1707322 1.000 rs3922887 chr1:46473802 A/G cg06784218 chr1:46089804 CCDC17 0.52 9.14 0.45 6.52e-18 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs1816752 0.666 rs7994022 chr13:25017230 A/G cg02811702 chr13:24901961 NA 0.47 6.48 0.34 3.27e-10 Obesity-related traits; CRC cis rs7208859 0.673 rs3816780 chr17:29161358 C/T cg13385521 chr17:29058706 SUZ12P 0.64 7.63 0.39 2.55e-13 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs9916302 0.904 rs8066704 chr17:37477218 C/T cg07936489 chr17:37558343 FBXL20 0.83 13.12 0.59 6.38e-32 Glomerular filtration rate (creatinine); CRC trans rs1814175 0.654 rs7482446 chr11:49779020 A/G cg03929089 chr4:120376271 NA -0.98 -19.42 -0.73 1.7e-56 Height; CRC cis rs11195062 0.766 rs7897645 chr10:112006669 C/A cg00817464 chr10:111662876 XPNPEP1 -0.37 -5.61 -0.3 4.32e-8 Multiple myeloma; CRC trans rs1005277 0.522 rs11011343 chr10:38002698 A/G cg27523141 chr10:43048294 ZNF37B 0.44 6.42 0.33 4.79e-10 Extrinsic epigenetic age acceleration; CRC trans rs1814175 0.615 rs4545557 chr11:50027329 A/C cg11707556 chr5:10655725 ANKRD33B -0.52 -10.25 -0.49 1.36e-21 Height; CRC cis rs7703744 0.681 rs73239278 chr5:118695051 G/A cg17471836 chr5:118691007 TNFAIP8 0.43 5.94 0.31 7.32e-9 Lobe attachment (rater-scored or self-reported); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg15928446 chr16:30661850 PRR14 0.42 6.23 0.32 1.46e-9 Intelligence (multi-trait analysis); CRC cis rs1448094 0.872 rs7313373 chr12:86398370 C/G cg02569458 chr12:86230093 RASSF9 0.39 6.62 0.34 1.46e-10 Major depressive disorder; CRC cis rs5753618 0.509 rs5997902 chr22:31583007 A/G cg22777020 chr22:31556080 RNF185 -0.53 -6.1 -0.32 2.92e-9 Colorectal cancer; CRC cis rs9517313 0.554 rs3809366 chr13:99230266 C/T cg07423050 chr13:99094983 FARP1 -0.55 -7.63 -0.39 2.62e-13 Neuroticism; CRC cis rs9329221 0.527 rs4841351 chr8:10327367 G/A cg27411982 chr8:10470053 RP1L1 -0.37 -5.81 -0.31 1.47e-8 Neuroticism; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg00779180 chr16:25117992 NA 0.44 6.03 0.32 4.52e-9 Anxiety disorder; CRC cis rs8031584 0.958 rs11629793 chr15:31238423 G/A cg08704250 chr15:31115839 NA -0.42 -7.68 -0.39 1.81e-13 Huntington's disease progression; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg09046255 chr16:30662126 PRR14 0.36 6.29 0.33 1.02e-9 Liver disease severity in Alagille syndrome; CRC cis rs7086627 0.515 rs10887901 chr10:82210581 G/A cg09626299 chr10:82213104 TSPAN14 -0.37 -6.25 -0.33 1.29e-9 Post bronchodilator FEV1; CRC cis rs73206853 0.614 rs57154770 chr12:110814415 T/C cg12870014 chr12:110450643 ANKRD13A 0.77 8.38 0.42 1.59e-15 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC cis rs1707322 0.717 rs12023439 chr1:46104636 C/T cg03146154 chr1:46216737 IPP 0.65 9.42 0.46 8.41e-19 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs7666738 0.830 rs10019087 chr4:99030211 C/T cg05340658 chr4:99064831 C4orf37 0.61 9.42 0.46 8.23e-19 Colonoscopy-negative controls vs population controls; CRC cis rs68170813 0.559 rs2107318 chr7:106845969 A/G cg02696742 chr7:106810147 HBP1 -0.62 -6.81 -0.35 4.76e-11 Coronary artery disease; CRC cis rs8060686 0.858 rs20549 chr16:67969930 A/G cg26727032 chr16:67993705 SLC12A4 -0.71 -10.71 -0.51 3.76e-23 HDL cholesterol;Metabolic syndrome; CRC cis rs4363385 0.747 rs6671524 chr1:152974247 C/G cg25856811 chr1:152973957 SPRR3 -0.25 -6.76 -0.35 6.27e-11 Inflammatory skin disease; CRC cis rs7259376 0.902 rs10420380 chr19:22600624 C/T cg02657401 chr19:22469223 NA 0.31 6.82 0.35 4.25e-11 Menopause (age at onset); CRC cis rs9868809 0.772 rs12107418 chr3:48689787 A/G cg00383909 chr3:49044727 WDR6 0.67 7.38 0.38 1.27e-12 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg00474734 chr12:53645975 MFSD5 0.42 7.45 0.38 8.19e-13 Liver disease severity in Alagille syndrome; CRC trans rs925098 0.577 rs2724470 chr4:17996046 A/G cg03646922 chr17:4167316 ANKFY1 -0.4 -6.05 -0.32 3.87e-9 Birth weight;Height; CRC cis rs6997458 0.742 rs20571 chr8:86351997 G/A cg21346043 chr8:86351067 CA3 -0.26 -5.87 -0.31 1.07e-8 Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; CRC cis rs6952808 0.723 rs60432611 chr7:2029629 G/C cg22963979 chr7:1858916 MAD1L1 -0.53 -7.7 -0.39 1.66e-13 Bipolar disorder and schizophrenia; CRC cis rs6694672 0.850 rs10801587 chr1:197058380 C/T cg13682187 chr1:196946512 CFHR5 0.55 8.27 0.42 3.27e-15 Asthma; CRC cis rs9640161 0.742 rs2159236 chr7:150017214 A/G cg13722127 chr7:150037890 RARRES2 0.51 7.94 0.4 3.18e-14 Blood protein levels;Circulating chemerin levels; CRC cis rs1577917 0.538 rs6454483 chr6:86418283 A/G cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A 0.42 5.65 0.3 3.4e-8 Response to antipsychotic treatment; CRC cis rs11758351 0.660 rs55848726 chr6:26224434 T/C cg08260959 chr6:26240920 HIST1H4F -0.35 -5.6 -0.3 4.44e-8 Gout;Renal underexcretion gout; CRC cis rs6696846 0.765 rs4394715 chr1:205108393 T/G cg00857998 chr1:205179979 DSTYK 0.46 6.31 0.33 8.95e-10 Red blood cell count; CRC cis rs4713118 0.868 rs9468220 chr6:27732976 A/G cg03623178 chr6:28175578 NA -0.71 -7.77 -0.39 9.91e-14 Parkinson's disease; CRC cis rs10504229 0.683 rs55986917 chr8:58137210 C/T cg21724239 chr8:58056113 NA 0.49 6.81 0.35 4.75e-11 Developmental language disorder (linguistic errors); CRC cis rs7772486 0.790 rs9485024 chr6:146142487 A/G cg13319975 chr6:146136371 FBXO30 0.4 6.07 0.32 3.51e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs12477438 0.798 rs1453562 chr2:99615850 G/A cg26064155 chr2:99771622 LIPT1;TSGA10 -0.79 -11.26 -0.53 4.29e-25 Chronic sinus infection; CRC cis rs8114671 0.562 rs4911449 chr20:33512236 T/G cg07148914 chr20:33460835 GGT7 0.39 6.33 0.33 8.21e-10 Height; CRC cis rs9311474 0.508 rs7614498 chr3:52618941 A/T cg08222913 chr3:52553049 STAB1 -0.34 -6.32 -0.33 8.43e-10 Electroencephalogram traits; CRC cis rs10751667 0.643 rs11246348 chr11:939476 G/C ch.11.42038R chr11:967971 AP2A2 0.6 10.27 0.49 1.24e-21 Alzheimer's disease (late onset); CRC cis rs11997175 0.574 rs4236733 chr8:33655582 G/A ch.8.33884649F chr8:33765107 NA 0.48 7.79 0.39 8.75e-14 Body mass index; CRC trans rs1973993 0.567 rs2800433 chr1:96998126 T/A cg10631902 chr5:14652156 NA 0.5 9.36 0.46 1.3e-18 Weight; CRC cis rs1580019 0.537 rs7804609 chr7:32558094 A/C cg06627557 chr7:32535165 LSM5;AVL9 0.96 17.94 0.7 1.16e-50 Cognitive ability; CRC cis rs1799949 0.602 rs8176235 chr17:41219560 C/T cg23758822 chr17:41437982 NA 0.77 11.22 0.53 5.97e-25 Menopause (age at onset); CRC cis rs9467711 0.606 rs34104395 chr6:26478252 C/T cg12315302 chr6:26189340 HIST1H4D 0.99 6.84 0.35 3.94e-11 Autism spectrum disorder or schizophrenia; CRC cis rs6500395 0.963 rs4785248 chr16:48687947 A/G cg04672837 chr16:48644449 N4BP1 -0.45 -6.63 -0.34 1.38e-10 Response to tocilizumab in rheumatoid arthritis; CRC cis rs780096 0.526 rs10182937 chr2:27651693 T/C cg24768116 chr2:27665128 KRTCAP3 -0.35 -7.97 -0.4 2.59e-14 Total body bone mineral density; CRC cis rs11226613 0.568 rs10895769 chr11:104954019 A/C cg04181079 chr11:104896587 CASP1 -0.41 -5.67 -0.3 3.11e-8 Bronchopulmonary dysplasia; CRC cis rs11958404 0.932 rs72816588 chr5:157434390 C/T cg05962755 chr5:157440814 NA 1.01 12.88 0.58 5.12e-31 IgG glycosylation; CRC cis rs67311347 1.000 rs2276868 chr3:40498845 C/T cg24209194 chr3:40518798 ZNF619 -0.45 -7.11 -0.36 7.37e-12 Renal cell carcinoma; CRC cis rs7119 0.651 rs12909292 chr15:77837982 G/T cg10437265 chr15:77819839 NA 0.63 10.81 0.51 1.58e-23 Type 2 diabetes; CRC cis rs4665809 0.877 rs35224700 chr2:26298037 T/C cg04944784 chr2:26401820 FAM59B 0.68 7.79 0.39 8.9e-14 Gut microbiome composition (summer); CRC cis rs950776 0.616 rs56276142 chr15:78889795 T/C cg06917634 chr15:78832804 PSMA4 0.53 8.1 0.41 1.1e-14 Sudden cardiac arrest; CRC cis rs10832963 0.686 rs11024743 chr11:18653712 A/G cg20219074 chr11:18656078 SPTY2D1 0.6 8.48 0.42 7.98e-16 Breast cancer; CRC cis rs970548 1.000 rs970548 chr10:46013277 A/C cg15590007 chr10:45870220 ALOX5 0.49 6.34 0.33 7.78e-10 Total cholesterol levels;Cholesterol, total;HDL cholesterol;HDL cholesterol levels; CRC cis rs9325144 0.534 rs1843887 chr12:38692380 T/C cg13010199 chr12:38710504 ALG10B 0.41 6.02 0.32 4.61e-9 Morning vs. evening chronotype; CRC cis rs9325144 0.647 rs35254764 chr12:39102928 T/C cg26384229 chr12:38710491 ALG10B -0.52 -7.34 -0.37 1.74e-12 Morning vs. evening chronotype; CRC cis rs2204008 0.744 rs66474616 chr12:38461564 G/A cg26384229 chr12:38710491 ALG10B 0.71 9.5 0.46 4.39e-19 Bladder cancer; CRC cis rs13108904 0.870 rs2291199 chr4:1244267 A/G cg16405210 chr4:1374714 KIAA1530 -0.42 -5.87 -0.31 1.06e-8 Obesity-related traits; CRC cis rs4253772 0.591 rs6007740 chr22:46654323 A/G cg03482458 chr22:46692211 CN5H6.4;GTSE1 -0.53 -7.05 -0.36 1.05e-11 LDL cholesterol;Cholesterol, total; CRC cis rs45430 1.000 rs364525 chr21:42745578 A/G cg22778903 chr21:42741698 MX2 -0.38 -6.26 -0.33 1.18e-9 Melanoma; CRC cis rs2617583 0.967 rs2550947 chr5:1450506 T/C cg07151155 chr5:1473589 LPCAT1 -0.42 -6.49 -0.34 3.19e-10 Breast cancer; CRC cis rs7119 0.717 rs34194537 chr15:77795761 G/A cg05673287 chr15:77411982 SGK269 -0.54 -8.05 -0.41 1.52e-14 Type 2 diabetes; CRC cis rs6988636 1.000 rs11992152 chr8:124189455 T/A cg27053337 chr8:124217698 FAM83A 0.44 6.91 0.36 2.58e-11 Urinary uromodulin levels; CRC trans rs2303319 0.504 rs62188990 chr2:162540635 G/A cg18122310 chr12:50236657 BCDIN3D -0.72 -6.22 -0.32 1.54e-9 Cognitive function; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg24715260 chr17:80056221 FASN 0.45 6.18 0.32 1.87e-9 Anxiety disorder; CRC cis rs720844 0.935 rs4972380 chr2:149336522 C/T cg09247360 chr2:149335327 NA -0.61 -7.7 -0.39 1.5700000000000001e-13 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs9875589 0.957 rs1433358 chr3:13943862 A/C cg19554555 chr3:13937349 NA 0.44 6.38 0.33 5.98e-10 Ovarian reserve; CRC cis rs644148 0.730 rs2117383 chr19:44978298 A/C cg15540054 chr19:45004280 ZNF180 0.54 6.74 0.35 7.19e-11 Personality dimensions; CRC cis rs7095944 0.584 rs11245347 chr10:126427037 G/T cg08799069 chr10:126477246 METTL10 -0.47 -7.42 -0.38 1.02e-12 Asthma; CRC cis rs600626 0.529 rs10899115 chr11:75471849 A/G cg24262691 chr11:75473276 NA 0.53 8.11 0.41 1.01e-14 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CRC cis rs2742417 1.000 rs1969626 chr3:45746836 A/G cg04837898 chr3:45731254 SACM1L -0.36 -5.92 -0.31 7.98e-9 Response to anti-depressant treatment in major depressive disorder; CRC cis rs727505 0.721 rs17327715 chr7:124760611 G/C cg23710748 chr7:124431027 NA -0.66 -11.23 -0.53 5.42e-25 Lewy body disease; CRC cis rs12505749 0.542 rs4340842 chr4:57338188 A/G cg06922635 chr4:57371607 ARL9 -0.54 -5.79 -0.3 1.62e-8 Airflow obstruction; CRC cis rs10256972 0.758 rs2280724 chr7:1064720 A/G cg07308232 chr7:1071921 C7orf50 -0.45 -6.15 -0.32 2.25e-9 Longevity;Endometriosis; CRC cis rs7412746 0.658 rs59024312 chr1:150909005 T/G cg17724175 chr1:150552817 MCL1 0.44 6.69 0.35 9.45e-11 Melanoma; CRC cis rs10504229 0.683 rs10504224 chr8:58143735 A/G cg02725872 chr8:58115012 NA -0.58 -8.44 -0.42 9.89e-16 Developmental language disorder (linguistic errors); CRC cis rs2204008 0.575 rs10444564 chr12:38043782 T/C cg26384229 chr12:38710491 ALG10B 0.68 9.03 0.45 1.48e-17 Bladder cancer; CRC cis rs8060686 0.858 rs7187289 chr16:67967878 A/C cg07125278 chr16:67683757 RLTPR -0.46 -5.95 -0.31 6.69e-9 HDL cholesterol;Metabolic syndrome; CRC trans rs925098 0.577 rs2724470 chr4:17996046 A/G cg19223106 chr19:58898630 RPS5 -0.42 -6.14 -0.32 2.32e-9 Birth weight;Height; CRC cis rs7607369 0.536 rs4674344 chr2:219669875 A/T cg02176678 chr2:219576539 TTLL4 -0.37 -5.82 -0.31 1.43e-8 Red blood cell count;Amyotrophic lateral sclerosis; CRC cis rs10256972 0.521 rs10280960 chr7:1103697 A/G cg07308232 chr7:1071921 C7orf50 -0.43 -6.22 -0.32 1.52e-9 Longevity;Endometriosis; CRC cis rs2692947 0.673 rs3111873 chr2:96781986 G/C cg23100626 chr2:96804247 ASTL -0.29 -7.74 -0.39 1.19e-13 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg10089324 chr1:51984752 EPS15 0.43 6.11 0.32 2.78e-9 Response to antipsychotic treatment; CRC cis rs62229266 0.693 rs2835264 chr21:37435965 C/T cg08632701 chr21:37451849 NA -0.41 -6.4 -0.33 5.41e-10 Mitral valve prolapse; CRC cis rs2811415 0.597 rs56211835 chr3:127803232 C/T cg13719885 chr3:127795394 NA -0.39 -5.9 -0.31 9.25e-9 Lung function (FEV1/FVC); CRC cis rs1552244 0.938 rs7647987 chr3:10140696 A/G cg13047869 chr3:10149882 C3orf24 0.51 7.34 0.37 1.72e-12 Alzheimer's disease; CRC cis rs4654899 1.000 rs2271115 chr1:21295864 C/T cg02927042 chr1:21476669 EIF4G3 -0.48 -7.78 -0.39 9.4e-14 Superior frontal gyrus grey matter volume; CRC cis rs2408955 0.542 rs7975632 chr12:48443048 C/T cg00601486 chr12:48723148 H1FNT 0.36 7.03 0.36 1.17e-11 Glycated hemoglobin levels; CRC trans rs2294025 0.932 rs7816892 chr8:134169898 A/G cg21959181 chr7:150755243 CDK5;SLC4A2 -0.35 -6.09 -0.32 3.19e-9 Graves' disease; CRC cis rs9303401 0.659 rs12150536 chr17:56640834 C/T cg10487724 chr17:56770010 TEX14;RAD51C 0.78 9.37 0.46 1.23e-18 Cognitive test performance; CRC cis rs13161895 1.000 rs34882290 chr5:179463836 C/A cg02702477 chr5:179499311 RNF130 0.54 6.22 0.32 1.52e-9 LDL cholesterol; CRC cis rs1799949 0.965 rs6503726 chr17:41284742 T/C cg19454999 chr17:41278357 BRCA1;NBR2 0.41 6.26 0.33 1.22e-9 Menopause (age at onset); CRC cis rs9921222 0.500 rs11645742 chr16:367516 C/T cg00101154 chr16:420108 MRPL28 -0.6 -7.61 -0.39 2.86e-13 Bone mineral density (spine);Bone mineral density; CRC cis rs17826219 0.561 rs11655876 chr17:29017150 G/A cg01831904 chr17:28903510 LRRC37B2 -0.53 -5.94 -0.31 7.38e-9 Body mass index; CRC cis rs4604732 0.642 rs10802514 chr1:247637749 A/C cg02104434 chr1:247694406 LOC148824;OR2C3 0.37 6.13 0.32 2.53e-9 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CRC cis rs7617773 0.780 rs71323396 chr3:48374734 T/G cg11946769 chr3:48343235 NME6 0.74 9.93 0.48 1.76e-20 Coronary artery disease; CRC cis rs6964587 0.934 rs1544377 chr7:91687351 A/G cg17063962 chr7:91808500 NA 0.8 14.02 0.61 2.36e-35 Breast cancer; CRC cis rs2882667 0.898 rs3925110 chr5:138371365 C/G cg04439458 chr5:138467593 SIL1 -0.33 -6.01 -0.31 5.04e-9 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs60871478 1.000 rs4374882 chr7:821798 C/T cg05535760 chr7:792225 HEATR2 0.82 11.36 0.53 1.89e-25 Cerebrospinal P-tau181p levels; CRC cis rs11167764 1.000 rs10057309 chr5:141479870 T/C cg08523384 chr5:141488047 NDFIP1 -0.51 -8.47 -0.42 8.2e-16 Crohn's disease; CRC cis rs787274 1.000 rs2796037 chr9:115511826 C/T cg13803584 chr9:115635662 SNX30 0.61 5.76 0.3 1.9e-8 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs9649213 0.593 rs6955647 chr7:98004562 T/C cg24562669 chr7:97807699 LMTK2 0.42 6.95 0.36 2.01e-11 Prostate cancer (SNP x SNP interaction); CRC cis rs1577917 0.958 rs4707236 chr6:86583967 A/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.51 -6.82 -0.35 4.5e-11 Response to antipsychotic treatment; CRC cis rs6066835 0.867 rs6095283 chr20:47374382 G/A cg18078177 chr20:47281410 PREX1 0.69 5.89 0.31 9.56e-9 Multiple myeloma; CRC cis rs9837602 1.000 rs9873878 chr3:99711816 G/T cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G 0.48 5.74 0.3 2.13e-8 Breast cancer; CRC trans rs9858542 0.903 rs17080528 chr3:49389842 C/T cg21582582 chr3:182698605 DCUN1D1 -0.53 -6.65 -0.34 1.25e-10 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs3785574 0.962 rs8079161 chr17:61808561 C/G cg25654072 chr17:61904446 PSMC5;FTSJ3 0.43 5.95 0.31 6.82e-9 Height; CRC cis rs7666738 0.830 rs6825211 chr4:98807698 A/T cg17366294 chr4:99064904 C4orf37 0.42 6.87 0.35 3.3e-11 Colonoscopy-negative controls vs population controls; CRC trans rs7615952 0.512 rs4234285 chr3:125404477 G/A cg17147758 chr8:6949321 NA -0.52 -7.37 -0.38 1.42e-12 Blood pressure (smoking interaction); CRC trans rs916888 0.821 rs199509 chr17:44858728 G/A cg07870213 chr5:140052090 DND1 -0.85 -10.09 -0.49 4.88e-21 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC trans rs208520 0.608 rs3846803 chr6:66805743 C/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.08 -15.32 -0.65 2.3e-40 Exhaled nitric oxide output; CRC cis rs568617 0.953 rs658938 chr11:65651830 A/G cg19792802 chr11:65647270 CTSW -0.5 -7.55 -0.38 4.23e-13 Crohn's disease; CRC cis rs9381040 0.701 rs6933231 chr6:41163700 T/C cg04346459 chr6:41068666 NFYA;LOC221442 -0.42 -6.59 -0.34 1.77e-10 Alzheimer's disease (late onset); CRC cis rs2013441 0.786 rs4003797 chr17:20288900 T/C cg13482628 chr17:19912719 NA -0.44 -6.69 -0.35 9.4e-11 Obesity-related traits; CRC cis rs713587 0.719 rs4665736 chr2:25187599 C/T cg04586622 chr2:25135609 ADCY3 0.35 5.96 0.31 6.35e-9 Body mass index in non-asthmatics; CRC cis rs8180040 0.603 rs9854790 chr3:47101306 T/G cg02527881 chr3:46936655 PTH1R -0.34 -5.91 -0.31 8.74e-9 Colorectal cancer; CRC cis rs847649 0.842 rs4729860 chr7:102625567 C/T cg18108683 chr7:102477205 FBXL13 0.53 8.64 0.43 2.44e-16 Morning vs. evening chronotype; CRC cis rs10256972 0.591 rs6950319 chr7:1161324 A/G cg07308232 chr7:1071921 C7orf50 -0.43 -5.7 -0.3 2.67e-8 Longevity;Endometriosis; CRC cis rs17767392 0.958 rs17767553 chr14:71910587 A/T cg13720639 chr14:72061746 SIPA1L1 -0.57 -7.29 -0.37 2.34e-12 Mitral valve prolapse; CRC cis rs6088580 0.634 rs2424992 chr20:33012060 C/T cg24642439 chr20:33292090 TP53INP2 0.37 6.3 0.33 9.54e-10 Glomerular filtration rate (creatinine); CRC cis rs992157 0.560 rs7578940 chr2:219083318 G/T cg04731861 chr2:219085781 ARPC2 0.37 7.75 0.39 1.13e-13 Colorectal cancer; CRC cis rs10463316 0.894 rs7723379 chr5:150765025 T/C cg03212797 chr5:150827313 SLC36A1 -0.49 -7.7 -0.39 1.6e-13 Metabolite levels (Pyroglutamine); CRC cis rs5758511 0.680 rs5751243 chr22:42617177 T/C cg00645731 chr22:42541494 CYP2D7P1 0.64 9.78 0.47 5.32e-20 Birth weight; CRC cis rs2576037 0.901 rs6507719 chr18:44581310 A/T cg07416455 chr18:44543612 TCEB3CL;KATNAL2 0.4 5.91 0.31 8.51e-9 Personality dimensions; CRC cis rs13108904 0.901 rs2293634 chr4:1291711 T/G cg20092199 chr4:1342459 KIAA1530 0.37 6.65 0.34 1.22e-10 Obesity-related traits; CRC cis rs4713118 0.824 rs2092075 chr6:27749330 G/C cg19041857 chr6:27730383 NA -0.44 -5.94 -0.31 7.12e-9 Parkinson's disease; CRC cis rs9811920 0.603 rs2638948 chr3:99501539 G/T cg07805332 chr3:99536008 MIR548G;C3orf26 0.39 5.97 0.31 6.11e-9 Axial length; CRC cis rs6831352 0.879 rs29001229 chr4:100046823 A/G cg12011299 chr4:100065546 ADH4 -0.49 -9.33 -0.46 1.6e-18 Alcohol dependence; CRC cis rs2857891 0.697 rs1004754 chr11:6946248 T/C cg06872519 chr11:6947619 ZNF215 0.59 5.86 0.31 1.11e-8 Response to cytadine analogues (cytosine arabinoside); CRC cis rs4713675 0.584 rs749847 chr6:33665001 G/C cg14003231 chr6:33640908 ITPR3 0.5 8.11 0.41 1.01e-14 Plateletcrit; CRC cis rs7216064 1.000 rs8079754 chr17:65887896 A/G cg12091567 chr17:66097778 LOC651250 -0.63 -7.47 -0.38 7.15e-13 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CRC cis rs11958404 0.932 rs7711898 chr5:157430688 A/G cg05962755 chr5:157440814 NA 1.01 12.88 0.58 5.12e-31 IgG glycosylation; CRC cis rs3018066 0.666 rs7669087 chr4:107032880 A/G cg01869342 chr4:106983673 TBCK 0.46 6.19 0.32 1.83e-9 Cancer; CRC trans rs57590327 0.504 rs4856348 chr3:81502923 T/G cg23387109 chr10:94051229 MARCH5;CPEB3 -0.45 -6.06 -0.32 3.7e-9 Extraversion; CRC cis rs798554 0.757 rs1183085 chr7:2875570 G/A cg04166393 chr7:2884313 GNA12 0.51 6.84 0.35 3.91e-11 Height; CRC cis rs9486715 1.000 rs9486725 chr6:97061159 C/T cg06623918 chr6:96969491 KIAA0776 -1.01 -19.37 -0.73 2.69e-56 Headache; CRC cis rs853679 0.760 rs11962305 chr6:28199937 G/C cg06470822 chr6:28175283 NA 0.77 8.09 0.41 1.18e-14 Depression; CRC cis rs2404602 0.716 rs17460201 chr15:76673627 C/T cg22467129 chr15:76604101 ETFA 0.43 7.2 0.37 4.25e-12 Blood metabolite levels; CRC cis rs6540556 0.634 rs11485195 chr1:209891738 T/C cg05527609 chr1:210001259 C1orf107 -0.55 -6.0 -0.31 5.1e-9 Red blood cell count; CRC cis rs8060686 0.641 rs75909028 chr16:68089578 A/C cg08314208 chr16:67682810 RLTPR -0.63 -6.75 -0.35 6.58e-11 HDL cholesterol;Metabolic syndrome; CRC cis rs7786877 0.500 rs2272572 chr7:100285888 C/T cg16850897 chr7:100343110 ZAN -0.59 -8.65 -0.43 2.38e-16 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs10256972 0.567 rs2949185 chr7:1209013 A/G cg23978390 chr7:1156363 C7orf50 0.52 7.25 0.37 2.95e-12 Longevity;Endometriosis; CRC cis rs6570726 0.557 rs403956 chr6:145829956 T/C cg23711669 chr6:146136114 FBXO30 0.62 9.3 0.46 1.95e-18 Lobe attachment (rater-scored or self-reported); CRC cis rs11628318 0.853 rs6575925 chr14:103034507 C/T cg08075719 chr14:103021372 NA -0.68 -9.22 -0.45 3.57e-18 Platelet count; CRC cis rs78456975 0.506 rs13402886 chr2:1575348 G/A cg12573674 chr2:1569213 NA -0.75 -10.05 -0.48 6.63e-21 Placebo response in major depressive disorder (% change in symptom score); CRC cis rs823143 0.570 rs823084 chr1:205798313 G/T cg26354017 chr1:205819088 PM20D1 0.63 9.77 0.47 5.82e-20 Monocyte percentage of white cells; CRC cis rs10504229 0.683 rs10504225 chr8:58145121 A/T cg02725872 chr8:58115012 NA -0.63 -11.21 -0.53 6.31e-25 Developmental language disorder (linguistic errors); CRC cis rs7589728 0.563 rs2292868 chr2:88475047 A/G cg04511125 chr2:88470314 THNSL2 -0.77 -7.92 -0.4 3.73e-14 Plasma clusterin levels; CRC trans rs877282 0.945 rs35342920 chr10:790484 T/C cg22713356 chr15:30763199 NA 1.34 16.68 0.68 1.08e-45 Uric acid levels; CRC cis rs7215564 0.908 rs4889884 chr17:78664465 A/G cg09596252 chr17:78655493 RPTOR 0.56 6.11 0.32 2.76e-9 Myopia (pathological); CRC cis rs911119 0.913 rs3810575 chr20:23583392 G/A cg16589663 chr20:23618590 CST3 0.42 5.76 0.3 1.95e-8 Chronic kidney disease; CRC cis rs17345786 0.906 rs58835747 chr3:101243634 T/C cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.56 6.55 0.34 2.24e-10 Colonoscopy-negative controls vs population controls; CRC cis rs11098499 0.954 rs35091806 chr4:120325529 G/A cg24375607 chr4:120327624 NA 0.51 7.98 0.4 2.49e-14 Corneal astigmatism; CRC cis rs2795502 0.564 rs3004259 chr10:43486041 A/G cg20628663 chr10:43360327 NA -0.59 -6.86 -0.35 3.49e-11 Blood protein levels; CRC cis rs2038227 1 rs2038227 chr16:539140 C/A cg02264733 chr16:588086 SOLH -0.37 -5.68 -0.3 2.9e-8 Venous thromboembolism (SNP x SNP interaction); CRC cis rs3106136 0.900 rs13142645 chr4:95208714 A/G cg11021082 chr4:95130006 SMARCAD1 -0.47 -7.37 -0.38 1.38e-12 Capecitabine sensitivity; CRC cis rs7107174 1.000 rs4945270 chr11:78068216 A/G cg02023728 chr11:77925099 USP35 0.5 7.49 0.38 6.44e-13 Testicular germ cell tumor; CRC cis rs7208859 0.623 rs9895785 chr17:29107708 C/T cg01831904 chr17:28903510 LRRC37B2 0.64 6.5 0.34 2.91e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs947211 0.948 rs12565968 chr1:205755046 A/G cg11965913 chr1:205819406 PM20D1 -0.41 -5.67 -0.3 3.21e-8 Parkinson's disease; CRC cis rs7799006 0.527 rs3779009 chr7:2203692 G/C cg08027265 chr7:2291960 NA -0.36 -5.74 -0.3 2.16e-8 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs4076764 1.000 rs12740984 chr1:163422151 A/G cg24596788 chr1:163392923 NA 0.63 10.07 0.49 5.61e-21 Motion sickness; CRC cis rs77861329 1.000 rs352148 chr3:52208898 A/G cg08692210 chr3:52188851 WDR51A 0.77 7.16 0.37 5.3e-12 Macrophage inflammatory protein 1b levels; CRC trans rs877282 1.000 rs7100358 chr10:773681 G/A cg22713356 chr15:30763199 NA 1.13 14.65 0.63 9.5e-38 Uric acid levels; CRC cis rs853679 0.517 rs9295759 chr6:28124469 C/T cg06470822 chr6:28175283 NA 1.03 13.59 0.6 1.04e-33 Depression; CRC cis rs17711722 0.523 rs365896 chr7:65510697 A/G cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.65 -10.33 -0.5 7.23e-22 Calcium levels; CRC cis rs9549367 0.713 rs9577211 chr13:113830718 G/C cg00898013 chr13:113819073 PROZ -0.54 -7.75 -0.39 1.19e-13 Platelet distribution width; CRC cis rs2415984 0.579 rs61993337 chr14:46965297 C/T cg14871534 chr14:47121158 RPL10L -0.42 -6.19 -0.32 1.83e-9 Number of children ever born; CRC cis rs898097 0.756 rs56249965 chr17:80806603 C/G cg19046167 chr17:80928561 B3GNTL1 -0.41 -6.21 -0.32 1.56e-9 Breast cancer; CRC cis rs801193 0.967 rs2420827 chr7:66147101 G/A cg11764359 chr7:65958608 NA -0.53 -8.05 -0.41 1.58e-14 Aortic root size; CRC trans rs9784649 1.000 rs11738315 chr5:24967891 T/C cg11038491 chr20:34638489 LOC647979 -0.59 -7.18 -0.37 4.59e-12 Peripheral arterial disease (traffic-related air pollution interaction); CRC trans rs2055729 0.634 rs6601390 chr8:9740657 A/G cg08975724 chr8:8085496 FLJ10661 0.49 6.43 0.33 4.37e-10 Multiple myeloma (hyperdiploidy); CRC cis rs28386778 0.787 rs2665827 chr17:61961350 G/C cg25654072 chr17:61904446 PSMC5;FTSJ3 0.72 10.71 0.51 3.66e-23 Prudent dietary pattern; CRC cis rs891088 0.614 rs41315074 chr19:7184243 C/G cg09779027 chr19:7224513 INSR -0.56 -5.96 -0.31 6.61e-9 Hip circumference adjusted for BMI;Height; CRC trans rs1005277 0.541 rs1740741 chr10:38515334 C/T cg23533926 chr12:111358616 MYL2 -0.56 -8.67 -0.43 2e-16 Extrinsic epigenetic age acceleration; CRC cis rs2239547 0.522 rs6773040 chr3:52935428 C/A cg18404041 chr3:52824283 ITIH1 0.35 6.4 0.33 5.36e-10 Schizophrenia; CRC cis rs7772486 0.790 rs7742333 chr6:146159029 A/G cg23711669 chr6:146136114 FBXO30 -0.69 -11.46 -0.53 7.99e-26 Lobe attachment (rater-scored or self-reported); CRC cis rs4919694 0.901 rs113541728 chr10:104716771 A/T cg04362960 chr10:104952993 NT5C2 1.11 10.4 0.5 4.45e-22 Arsenic metabolism; CRC cis rs10751667 0.666 rs7394992 chr11:980690 G/C cg23136738 chr11:925521 AP2A2 -0.42 -7.14 -0.37 6.07e-12 Alzheimer's disease (late onset); CRC cis rs61160187 0.582 rs976631 chr5:60216043 T/C cg16298547 chr5:60138761 ELOVL7 -0.28 -5.97 -0.31 6.06e-9 Educational attainment (years of education);Educational attainment (college completion); CRC cis rs7635838 0.684 rs2606758 chr3:11353064 G/A cg00170343 chr3:11313890 ATG7 0.48 7.46 0.38 7.66e-13 HDL cholesterol; CRC trans rs73162807 0.655 rs73160973 chr3:146422587 G/A cg26896787 chr1:228603707 TRIM17 -0.59 -5.99 -0.31 5.61e-9 Platelet-derived growth factor BB levels; CRC cis rs950169 0.920 rs2135551 chr15:84707851 A/G cg03959625 chr15:84868606 LOC388152 0.41 6.08 0.32 3.27e-9 Schizophrenia; CRC cis rs9462846 0.853 rs9462850 chr6:42872475 C/T cg21280719 chr6:42927975 GNMT -0.33 -6.47 -0.34 3.65e-10 Blood protein levels; CRC cis rs939574 0.660 rs6716253 chr2:220127016 G/A cg00496455 chr2:220118770 TUBA4A;TUBA4B 0.85 7.43 0.38 9.29e-13 Platelet distribution width; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg16780568 chr10:89578019 ATAD1;CFLP1 0.35 6.09 0.32 3.14e-9 Liver disease severity in Alagille syndrome; CRC cis rs1799949 0.894 rs71367985 chr17:41374463 G/A cg25072359 chr17:41440525 NA 0.53 8.5 0.42 6.79e-16 Menopause (age at onset); CRC cis rs11583043 0.958 rs12746722 chr1:101464789 G/T cg16556008 chr1:101360663 SLC30A7;EXTL2 0.46 6.05 0.32 3.97e-9 Ulcerative colitis;Inflammatory bowel disease; CRC trans rs17685 0.725 rs4476928 chr7:75642107 C/A cg19862616 chr7:65841803 NCRNA00174 -0.97 -18.08 -0.71 3.18e-51 Coffee consumption;Coffee consumption (cups per day); CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg22968175 chr19:42721878 DEDD2 0.46 5.96 0.31 6.48e-9 Thyroid stimulating hormone; CRC cis rs4689388 0.926 rs4308429 chr4:6294001 A/G cg14416269 chr4:6271139 WFS1 0.4 6.62 0.34 1.43e-10 Type 2 diabetes and other traits;Type 2 diabetes; CRC cis rs875971 0.528 rs801213 chr7:66014918 C/T cg18876405 chr7:65276391 NA -0.44 -6.21 -0.32 1.57e-9 Aortic root size; CRC cis rs2839186 0.619 rs2187118 chr21:47611310 C/T cg13012494 chr21:47604986 C21orf56 0.45 7.26 0.37 2.77e-12 Testicular germ cell tumor; CRC cis rs4665809 0.590 rs2033317 chr2:26477650 G/A cg08067268 chr2:26466485 HADHB;HADHA 0.64 8.39 0.42 1.46e-15 Gut microbiome composition (summer); CRC cis rs6502050 0.805 rs7406858 chr17:80080623 G/A cg09264619 chr17:80180166 NA 0.37 6.13 0.32 2.47e-9 Life satisfaction; CRC cis rs3126085 0.735 rs4845752 chr1:152226576 C/A cg09127314 chr1:152161683 NA 0.47 5.99 0.31 5.57e-9 Atopic dermatitis; CRC cis rs7680126 0.596 rs10020887 chr4:10140751 C/G cg00071950 chr4:10020882 SLC2A9 -0.47 -6.13 -0.32 2.51e-9 Urate levels in lean individuals;Urate levels in overweight individuals;Urate levels in obese individuals; CRC trans rs7944735 0.517 rs12274550 chr11:48196752 C/A cg03929089 chr4:120376271 NA 0.59 6.07 0.32 3.62e-9 Intraocular pressure; CRC cis rs28386778 0.830 rs67905415 chr17:61841236 G/A cg23090583 chr17:61904693 PSMC5;FTSJ3 1.04 20.65 0.75 2.49e-61 Prudent dietary pattern; CRC cis rs1448094 0.933 rs11836175 chr12:86311644 A/T cg02569458 chr12:86230093 RASSF9 0.38 6.49 0.34 3.21e-10 Major depressive disorder; CRC trans rs1728785 1.000 rs1645976 chr16:68563509 T/C cg04657470 chr2:198365150 HSPE1;HSPD1 0.57 6.78 0.35 5.72e-11 Ulcerative colitis; CRC cis rs1552244 0.572 rs68013239 chr3:10165711 G/T cg16606324 chr3:10149918 C3orf24 0.66 7.74 0.39 1.19e-13 Alzheimer's disease; CRC cis rs9837602 1.000 rs17379739 chr3:99724792 G/A cg07805332 chr3:99536008 MIR548G;C3orf26 -0.51 -6.79 -0.35 5.11e-11 Breast cancer; CRC cis rs2072499 1.000 rs2072499 chr1:156169610 A/G cg24450063 chr1:156163899 SLC25A44 1.13 27.34 0.83 1.06e-86 Testicular germ cell tumor; CRC cis rs17401966 0.931 rs1002076 chr1:10438892 G/A cg19773385 chr1:10388646 KIF1B -0.69 -11.04 -0.52 2.5e-24 Hepatocellular carcinoma; CRC cis rs889312 0.500 rs252906 chr5:56119190 G/T cg18230493 chr5:56204884 C5orf35 -0.43 -6.4 -0.33 5.29e-10 Breast cancer;Breast cancer (early onset); CRC cis rs4423214 1.000 rs11606612 chr11:71164047 C/A cg05163923 chr11:71159392 DHCR7 0.67 9.53 0.46 3.69e-19 Vitamin D levels; CRC cis rs514406 0.861 rs12038438 chr1:53230581 A/T cg08859206 chr1:53392774 SCP2 0.43 6.6 0.34 1.66e-10 Monocyte count; CRC cis rs870825 0.698 rs2696046 chr4:185599972 G/A cg04058563 chr4:185651563 MLF1IP -0.54 -5.83 -0.31 1.35e-8 Blood protein levels; CRC cis rs651907 0.557 rs2318090 chr3:101474933 A/G cg12386194 chr3:101231763 SENP7 0.48 6.98 0.36 1.59e-11 Colorectal cancer; CRC cis rs7727544 0.716 rs4705926 chr5:131561758 C/T cg04518342 chr5:131593106 PDLIM4 0.36 6.57 0.34 1.97e-10 Blood metabolite levels; CRC cis rs3087591 0.887 rs7503395 chr17:29440554 C/T cg24425628 chr17:29625626 OMG;NF1 0.86 16.45 0.67 8.73e-45 Hip circumference; CRC cis rs2228479 0.850 rs2238527 chr16:89840708 C/A cg06558623 chr16:89946397 TCF25 1.09 10.23 0.49 1.69e-21 Skin colour saturation; CRC cis rs4713118 0.621 rs4713134 chr6:28034121 T/C cg12273811 chr6:28175739 NA 0.63 8.16 0.41 7.43e-15 Parkinson's disease; CRC trans rs11088226 0.681 rs8131384 chr21:33944127 C/T cg09050820 chr6:167586206 TCP10L2 0.86 9.0 0.44 1.79e-17 Gastritis; CRC cis rs9372498 0.536 rs62422220 chr6:118923731 G/A cg24463073 chr6:118973353 C6orf204 0.51 6.75 0.35 6.86e-11 Diastolic blood pressure; CRC trans rs1127311 1.000 rs10908419 chr1:154567699 G/A cg05270119 chr15:66161672 RAB11A 0.44 6.06 0.32 3.75e-9 C-reactive protein levels or triglyceride levels (pleiotropy); CRC cis rs11971779 0.680 rs4732376 chr7:139098024 G/A cg07862535 chr7:139043722 LUC7L2 0.57 7.32 0.37 1.92e-12 Diisocyanate-induced asthma; CRC cis rs898097 0.841 rs9896263 chr17:80902741 A/G cg16060761 chr17:80687452 NA -0.4 -5.78 -0.3 1.69e-8 Breast cancer; CRC cis rs4731207 0.596 rs1600737 chr7:124639547 C/T cg23710748 chr7:124431027 NA -0.39 -6.2 -0.32 1.68e-9 Cutaneous malignant melanoma; CRC cis rs28386778 0.830 rs2665798 chr17:61921397 C/T cg22520471 chr17:61851767 DDX42;CCDC47 0.75 11.71 0.54 1.02e-26 Prudent dietary pattern; CRC cis rs2228479 0.867 rs11645970 chr16:89958118 G/A cg04013166 chr16:89971882 TCF25 0.6 5.76 0.3 1.91e-8 Skin colour saturation; CRC cis rs10078 0.571 rs2561664 chr5:459793 T/C cg07599136 chr5:415885 AHRR 0.72 7.18 0.37 4.65e-12 Fat distribution (HIV); CRC cis rs10504229 0.683 rs73603877 chr8:58108428 C/T cg04204079 chr8:58130323 NA -0.46 -5.8 -0.3 1.58e-8 Developmental language disorder (linguistic errors); CRC cis rs7618915 0.547 rs3774365 chr3:52642487 T/C cg18099408 chr3:52552593 STAB1 -0.45 -7.42 -0.38 1.02e-12 Bipolar disorder; CRC cis rs9648716 0.766 rs511001 chr7:140782039 G/T cg10747023 chr7:140774559 NA -0.47 -6.11 -0.32 2.85e-9 Type 2 diabetes; CRC cis rs10979 1.000 rs6570565 chr6:143899531 C/T cg25407410 chr6:143891975 LOC285740 -0.8 -12.72 -0.57 2e-30 Hypospadias; CRC cis rs7542091 0.506 rs992976 chr1:210066658 A/T cg22029157 chr1:209979665 IRF6 -0.41 -6.42 -0.33 4.65e-10 Monobrow; CRC cis rs9462027 0.628 rs6942040 chr6:34761809 A/C cg07306190 chr6:34760872 UHRF1BP1 -0.35 -6.24 -0.33 1.31e-9 Systemic lupus erythematosus; CRC cis rs1941023 0.606 rs7946122 chr11:60172770 G/A cg08716584 chr11:60157161 MS4A7 -0.57 -9.23 -0.45 3.44e-18 Congenital heart disease (maternal effect); CRC trans rs7615952 0.543 rs4645102 chr3:125424441 A/G cg21747405 chr11:67723411 NA -0.57 -8.88 -0.44 4.28e-17 Blood pressure (smoking interaction); CRC cis rs2739330 0.760 rs5751761 chr22:24243736 A/G cg16132339 chr22:24313637 DDTL;DDT -0.56 -8.69 -0.43 1.69e-16 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs1143633 0.537 rs4447608 chr2:113605957 C/T cg12858261 chr2:113808755 IL1F8 -0.35 -5.76 -0.3 1.97e-8 Allergic disease (asthma, hay fever or eczema); CRC trans rs7690467 0.926 rs62318141 chr4:133388785 A/C cg19296258 chr17:78878799 RPTOR -0.47 -6.29 -0.33 1e-9 Eating disorders; CRC cis rs2252790 0.859 rs2858848 chr6:116679275 A/G cg18764771 chr6:116381957 FRK -0.22 -6.01 -0.31 4.85e-9 Fast beta electroencephalogram; CRC cis rs7487075 0.619 rs12314541 chr12:46794766 T/C cg22049899 chr12:47219821 SLC38A4 0.32 5.88 0.31 1.01e-8 Itch intensity from mosquito bite; CRC cis rs7909074 1.000 rs4948925 chr10:45392455 C/T cg04218760 chr10:45406644 TMEM72 -0.35 -10.08 -0.49 5.32e-21 Mean corpuscular volume; CRC trans rs2727020 0.658 rs4980440 chr11:49386017 C/T cg15704280 chr7:45808275 SEPT13 -0.91 -16.89 -0.68 1.54e-46 Coronary artery disease; CRC cis rs2921036 0.529 rs2979192 chr8:8338147 C/T cg08975724 chr8:8085496 FLJ10661 0.42 6.14 0.32 2.36e-9 Neuroticism; CRC cis rs35110281 0.693 rs4819290 chr21:45122713 C/T cg01579765 chr21:45077557 HSF2BP -0.35 -6.53 -0.34 2.49e-10 Mean corpuscular volume; CRC cis rs13191362 1.000 rs13193282 chr6:163015442 T/C cg23758597 chr6:163146217 PARK2 -0.56 -6.17 -0.32 2.03e-9 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs2731664 0.792 rs1130857 chr5:176863519 G/C cg23176889 chr5:176863531 GRK6 -0.73 -16.44 -0.67 9.36e-45 Intelligence (multi-trait analysis); CRC cis rs3815700 1.000 rs2287670 chr19:33095057 G/A cg02997394 chr19:33096574 ANKRD27 0.73 8.31 0.42 2.61e-15 Eosinophilic esophagitis; CRC cis rs776905 0.598 rs569557 chr13:113769917 G/A cg09069900 chr13:113776964 F10 -0.44 -6.94 -0.36 2.11e-11 Blood protein levels; CRC cis rs4665809 0.652 rs6727974 chr2:26524639 A/G cg26119090 chr2:26468346 HADHA;HADHB 0.8 11.46 0.53 8.25e-26 Gut microbiome composition (summer); CRC cis rs2204008 0.641 rs2387810 chr12:38368875 G/T cg26384229 chr12:38710491 ALG10B 0.69 9.77 0.47 5.7e-20 Bladder cancer; CRC cis rs7107174 1.000 rs10899455 chr11:77999163 T/C cg02023728 chr11:77925099 USP35 0.52 8.35 0.42 1.9e-15 Testicular germ cell tumor; CRC cis rs1552244 1.000 rs9875081 chr3:10083935 G/A cg18598329 chr3:10140678 FANCD2;C3orf24 -0.89 -12.69 -0.57 2.6e-30 Alzheimer's disease; CRC cis rs7584330 0.554 rs57140815 chr2:238428330 A/G cg14458575 chr2:238380390 NA 0.43 6.04 0.32 4.26e-9 Prostate cancer; CRC cis rs10911232 0.507 rs10797816 chr1:182998486 A/T ch.1.3577855R chr1:183094577 LAMC1 0.81 13.36 0.59 8.15e-33 Hypertriglyceridemia; CRC cis rs6840360 0.574 rs2709844 chr4:152368212 C/T cg09659197 chr4:152720779 NA 0.33 6.61 0.34 1.57e-10 Intelligence (multi-trait analysis); CRC cis rs1448094 0.512 rs7303330 chr12:86255123 G/A cg18827107 chr12:86230957 RASSF9 -0.45 -7.38 -0.38 1.33e-12 Major depressive disorder; CRC cis rs7246657 0.943 rs8109038 chr19:38015709 A/G cg23950597 chr19:37808831 NA 0.54 6.27 0.33 1.13e-9 Coronary artery calcification; CRC cis rs28386778 0.897 rs2854208 chr17:61946885 C/T cg25654072 chr17:61904446 PSMC5;FTSJ3 0.71 10.92 0.52 6.8e-24 Prudent dietary pattern; CRC cis rs881375 0.967 rs10435843 chr9:123668033 A/G cg09586646 chr9:123605570 PSMD5;LOC253039 0.53 7.17 0.37 5.01e-12 Rheumatoid arthritis; CRC cis rs28386778 0.966 rs2008053 chr17:61954918 G/C cg00280220 chr17:61926910 NA 0.33 5.67 0.3 3.12e-8 Prudent dietary pattern; CRC trans rs8012941 0.593 rs4902190 chr14:63314591 A/G cg03143876 chr20:50808547 ZFP64 0.39 6.13 0.32 2.58e-9 Major depressive disorder; CRC cis rs802075 0.967 rs554805 chr6:49653451 A/G cg20364632 chr6:49636226 NA -0.35 -5.78 -0.3 1.71e-8 Bone mineral density (hip) and age at menarche; CRC cis rs709400 0.930 rs61996717 chr14:104048571 T/C cg01849466 chr14:104193079 ZFYVE21 0.38 5.95 0.31 7.01e-9 Body mass index; CRC cis rs10193935 1.000 rs72796507 chr2:42409840 A/G cg27598129 chr2:42591480 NA -0.65 -7.58 -0.39 3.45e-13 Colonoscopy-negative controls vs population controls; CRC cis rs3087591 0.920 rs2905881 chr17:29547862 T/C cg24425628 chr17:29625626 OMG;NF1 0.86 16.9 0.68 1.39e-46 Hip circumference; CRC cis rs801193 0.569 rs2659893 chr7:66199993 G/A cg18252515 chr7:66147081 NA -0.41 -5.81 -0.3 1.5e-8 Aortic root size; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg00258805 chr17:29876732 NA 0.36 6.07 0.32 3.57e-9 Liver disease severity in Alagille syndrome; CRC cis rs7829975 0.606 rs11776838 chr8:8794801 C/T cg06636001 chr8:8085503 FLJ10661 -0.51 -7.73 -0.39 1.3e-13 Mood instability; CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg15929228 chr2:240323491 HDAC4 0.37 6.03 0.32 4.53e-9 Obesity-related traits; CRC cis rs7178375 0.607 rs12903674 chr15:31194552 G/C cg14829155 chr15:31115871 NA -0.6 -5.93 -0.31 7.79e-9 Hypertriglyceridemia; CRC cis rs2953174 0.786 rs2953177 chr2:241516616 A/G cg07929629 chr2:241523174 NA 0.51 5.97 0.31 6.1e-9 Bipolar disorder; CRC cis rs9733 0.596 rs72702523 chr1:150650425 G/T cg17724175 chr1:150552817 MCL1 0.58 9.38 0.46 1.11e-18 Tonsillectomy; CRC cis rs11098499 0.730 rs12505735 chr4:120532956 G/T cg09307838 chr4:120376055 NA 0.68 10.09 0.49 4.96e-21 Corneal astigmatism; CRC cis rs28386778 0.591 rs2584619 chr17:61913215 T/A cg25654072 chr17:61904446 PSMC5;FTSJ3 0.72 11.22 0.53 6.14e-25 Prudent dietary pattern; CRC cis rs4665809 0.941 rs6735145 chr2:26270302 T/C cg04944784 chr2:26401820 FAM59B -0.6 -7.72 -0.39 1.37e-13 Gut microbiome composition (summer); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg07589846 chr1:212872696 BATF3 0.4 6.42 0.33 4.81e-10 Liver disease severity in Alagille syndrome; CRC cis rs2019137 0.868 rs6755639 chr2:113981810 A/G cg25243455 chr2:114033360 PAX8;LOC440839 -0.25 -5.76 -0.3 1.9e-8 Lymphocyte counts; CRC cis rs2243480 1.000 rs78803505 chr7:65382572 A/T cg12463550 chr7:65579703 CRCP 0.63 6.04 0.32 4.17e-9 Diabetic kidney disease; CRC cis rs11758351 1.000 rs76722536 chr6:26192946 C/G cg22723502 chr6:26240528 HIST1H4F -0.39 -5.95 -0.31 6.71e-9 Gout;Renal underexcretion gout; CRC cis rs6089584 0.888 rs6061973 chr20:60610870 C/T cg23262073 chr20:60523788 NA -0.45 -6.89 -0.36 2.78e-11 Body mass index; CRC cis rs7113874 0.550 rs10840084 chr11:8609274 G/A cg20771178 chr11:8615675 STK33 0.35 5.68 0.3 3e-8 Body mass index in physically active individuals;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs9494145 0.590 rs9376090 chr6:135411228 T/C cg22676075 chr6:135203613 NA 0.59 7.51 0.38 5.48e-13 Mean platelet volume;Platelet count;Fetal hemoglobin levels in sickle cell anemia;Red blood cell traits; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg02717630 chr16:46865118 C16orf87 0.43 7.29 0.37 2.38e-12 Liver disease severity in Alagille syndrome; CRC cis rs10791323 0.569 rs10736608 chr11:133740048 C/T cg15485101 chr11:133734466 NA 0.43 8.1 0.41 1.06e-14 Childhood ear infection; CRC trans rs264943 0.575 rs171952 chr2:104092943 A/G cg24033067 chr14:24674799 TSSK4 -0.41 -6.01 -0.31 4.94e-9 HIV-1 viral setpoint; CRC cis rs9359856 0.600 rs17584763 chr6:90502088 G/A cg13799429 chr6:90582589 CASP8AP2 -0.72 -8.06 -0.41 1.46e-14 Bipolar disorder; CRC cis rs897984 0.683 rs12447534 chr16:30804257 C/T cg00531865 chr16:30841666 NA 0.5 7.34 0.38 1.7e-12 Dementia with Lewy bodies; CRC cis rs6540556 0.608 rs4314885 chr1:209902704 G/A cg23920097 chr1:209922102 NA -0.47 -5.76 -0.3 1.91e-8 Red blood cell count; CRC cis rs9323205 0.577 rs9672038 chr14:51724856 A/G cg23942311 chr14:51606299 NA -0.56 -8.28 -0.42 3.04e-15 Cancer; CRC cis rs7258465 1.000 rs10411009 chr19:18606266 A/G cg10790698 chr19:18539756 SSBP4 -0.43 -8.31 -0.42 2.61e-15 Breast cancer; CRC cis rs9916302 0.706 rs9891892 chr17:37479856 A/C cg15445000 chr17:37608096 MED1 -0.34 -6.04 -0.32 4.2e-9 Glomerular filtration rate (creatinine); CRC cis rs6432018 1.000 rs11887863 chr2:9739429 G/T cg12832956 chr2:9616023 IAH1 -0.37 -5.62 -0.3 4.14e-8 Heart rate variability traits; CRC trans rs6561151 0.957 rs2121034 chr13:44473866 G/T cg17145862 chr1:211918768 LPGAT1 0.5 7.11 0.36 7.31e-12 Crohn's disease; CRC cis rs6831352 0.918 rs7670241 chr4:100059619 G/T cg13256891 chr4:100009986 ADH5 -0.66 -8.89 -0.44 4.04e-17 Alcohol dependence; CRC cis rs919433 0.783 rs55725278 chr2:198238223 C/T cg10820045 chr2:198174542 NA 0.45 8.01 0.4 1.99e-14 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC cis rs7849270 0.959 rs10760591 chr9:131915028 A/G cg13538475 chr9:131942899 NA -0.31 -5.97 -0.31 6.05e-9 Blood metabolite ratios; CRC cis rs9303401 0.659 rs36093395 chr17:56957357 C/T cg02118635 chr17:56770003 RAD51C;TEX14 0.78 9.94 0.48 1.59e-20 Cognitive test performance; CRC cis rs875971 0.660 rs1860468 chr7:66107252 T/C cg00343986 chr7:65444356 GUSB -0.51 -7.61 -0.39 3e-13 Aortic root size; CRC cis rs2228479 0.850 rs11649100 chr16:89798179 A/G cg06558623 chr16:89946397 TCF25 1.16 10.93 0.52 6.45e-24 Skin colour saturation; CRC cis rs425277 0.628 rs3107147 chr1:2048729 G/A cg24578937 chr1:2090814 PRKCZ -0.44 -7.91 -0.4 3.86e-14 Height; CRC cis rs3091242 0.933 rs7541095 chr1:25761291 T/C cg23205692 chr1:25664452 TMEM50A 0.43 6.15 0.32 2.23e-9 Erythrocyte sedimentation rate; CRC cis rs3789045 0.729 rs12039968 chr1:204490674 C/T cg17419461 chr1:204415978 PIK3C2B -0.57 -7.95 -0.4 3.06e-14 Educational attainment (college completion); CRC cis rs7517126 1.000 rs6428369 chr1:196844335 A/G cg13682187 chr1:196946512 CFHR5 -0.35 -5.63 -0.3 3.9e-8 Blood protein levels; CRC cis rs9527 0.571 rs12765337 chr10:104635344 G/C cg04362960 chr10:104952993 NT5C2 0.6 8.47 0.42 8.16e-16 Arsenic metabolism; CRC cis rs10504229 0.639 rs67996345 chr8:58117127 A/G cg22535103 chr8:58192502 C8orf71 -0.7 -9.34 -0.46 1.47e-18 Developmental language disorder (linguistic errors); CRC cis rs2836974 0.965 rs8134733 chr21:40683459 C/T cg06238570 chr21:40685208 BRWD1 0.79 10.81 0.51 1.61e-23 Cognitive function; CRC cis rs1448094 0.511 rs10506918 chr12:86227913 A/G cg19622623 chr12:86230825 RASSF9 0.39 6.25 0.33 1.27e-9 Major depressive disorder; CRC cis rs9443645 0.869 rs9448591 chr6:79606490 C/T cg11833968 chr6:79620685 NA -0.37 -6.47 -0.34 3.53e-10 Intelligence (multi-trait analysis); CRC cis rs853679 0.517 rs9380047 chr6:28037893 G/T cg15845792 chr6:28175446 NA 0.96 12.86 0.58 6.21e-31 Depression; CRC cis rs7917772 0.536 rs4919667 chr10:104426011 A/G cg22532475 chr10:104410764 TRIM8 0.38 6.48 0.34 3.3e-10 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC cis rs7937682 0.883 rs12804962 chr11:111442683 A/T cg19812747 chr11:111475976 SIK2 0.55 9.18 0.45 4.98e-18 Primary sclerosing cholangitis; CRC cis rs8177179 0.503 rs13061966 chr3:133412277 C/A cg24879335 chr3:133465180 TF 0.31 5.64 0.3 3.75e-8 Iron status biomarkers (transferrin levels); CRC cis rs933688 1.000 rs61612071 chr5:90741470 G/A cg26981201 chr5:90679533 LOC100129716;ARRDC3 0.98 15.01 0.64 3.59e-39 Smoking behavior; CRC cis rs910316 0.737 rs175510 chr14:75524839 G/A cg11812906 chr14:75593930 NEK9 -0.59 -9.18 -0.45 4.87e-18 Height; CRC cis rs2836974 0.644 rs2836986 chr21:40702136 A/C cg17971929 chr21:40555470 PSMG1 -0.63 -9.03 -0.45 1.45e-17 Cognitive function; CRC cis rs6860806 0.507 rs274570 chr5:131713226 C/T cg07395648 chr5:131743802 NA 0.41 5.63 0.3 3.84e-8 Breast cancer; CRC cis rs3858526 0.883 rs11039584 chr11:5935251 C/G cg13902645 chr11:5959945 NA -0.61 -8.44 -0.42 1.01e-15 DNA methylation (variation); CRC cis rs7843479 0.601 rs4422769 chr8:21844265 A/G cg16476235 chr8:21771668 DOK2 0.39 6.65 0.34 1.22e-10 Mean corpuscular volume; CRC cis rs78456975 1.000 rs13422995 chr2:1553554 C/A cg12573674 chr2:1569213 NA -0.75 -7.87 -0.4 5.22e-14 Placebo response in major depressive disorder (% change in symptom score); CRC cis rs896854 0.684 rs10099941 chr8:95987008 C/T cg13393036 chr8:95962371 TP53INP1 -0.51 -8.76 -0.43 1.05e-16 Type 2 diabetes; CRC cis rs6570726 0.935 rs12663204 chr6:145818373 G/A cg05347473 chr6:146136440 FBXO30 0.37 6.0 0.31 5.27e-9 Lobe attachment (rater-scored or self-reported); CRC trans rs7395662 0.658 rs11493304 chr11:48895591 C/T cg21153622 chr11:89784906 NA -0.47 -7.42 -0.38 9.85e-13 HDL cholesterol; CRC cis rs887797 0.557 rs8072699 chr17:64592569 T/C cg27019712 chr17:64599478 PRKCA -0.36 -5.66 -0.3 3.36e-8 Possible neuropathic pain in post total joint replacement surgery for osteoarthritis; CRC cis rs34375054 0.573 rs12811438 chr12:125653490 C/T cg25124228 chr12:125621409 AACS -0.58 -6.58 -0.34 1.88e-10 Post bronchodilator FEV1/FVC ratio; CRC cis rs9894429 0.608 rs7406382 chr17:79597786 T/C cg21028142 chr17:79581711 NPLOC4 0.34 7.14 0.37 5.88e-12 Eye color traits; CRC cis rs10911363 0.592 rs12117885 chr1:183494214 C/T cg09173681 chr1:183549694 NCF2 -0.73 -10.41 -0.5 3.92e-22 Systemic lupus erythematosus; CRC cis rs1799949 1.000 rs1545764 chr17:41424565 G/A cg25072359 chr17:41440525 NA 0.44 6.4 0.33 5.49e-10 Menopause (age at onset); CRC cis rs1552172 0.922 rs17352469 chr1:145693383 A/G cg11743829 chr1:145714124 CD160 -0.4 -6.07 -0.32 3.49e-9 Breast cancer; CRC cis rs995000 0.931 rs2131925 chr1:63025942 G/T cg19896129 chr1:63156450 NA -0.43 -6.67 -0.35 1.06e-10 Triglyceride levels; CRC cis rs2444217 0.872 rs2531977 chr16:4043701 C/G cg09300795 chr16:4042428 ADCY9 0.43 6.64 0.34 1.33e-10 Body mass index; CRC cis rs2969070 0.867 rs2906166 chr7:2508072 A/G cg03277898 chr7:2518824 NA -0.43 -6.25 -0.33 1.31e-9 Diastolic blood pressure; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg11276456 chr10:74856846 P4HA1 0.43 6.46 0.34 3.77e-10 Intelligence (multi-trait analysis); CRC cis rs9914988 1.000 rs9916866 chr17:27183155 C/G cg20469991 chr17:27169893 C17orf63 0.47 5.85 0.31 1.2e-8 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs9733 0.536 rs6661415 chr1:150635869 G/A cg18016565 chr1:150552671 MCL1 0.47 6.81 0.35 4.55e-11 Tonsillectomy; CRC cis rs2346177 0.513 rs1530625 chr2:46658067 C/T cg26688816 chr2:46740690 ATP6V1E2 -0.58 -9.46 -0.46 6.02e-19 HDL cholesterol; CRC cis rs9486715 0.867 rs4240553 chr6:96965324 T/C cg18709589 chr6:96969512 KIAA0776 0.48 7.06 0.36 9.66e-12 Headache; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg04542325 chr14:76452293 C14orf179 0.44 5.96 0.31 6.47e-9 Anxiety disorder; CRC cis rs1580019 0.883 rs6945294 chr7:32472099 G/A cg06627557 chr7:32535165 LSM5;AVL9 0.81 12.47 0.57 1.65e-29 Cognitive ability; CRC cis rs6088590 1.000 rs6119530 chr20:33403930 A/G cg08999081 chr20:33150536 PIGU 0.53 8.98 0.44 2.13e-17 Coronary artery disease; CRC trans rs2303319 0.504 rs62189048 chr2:162613494 G/C cg22902534 chr3:183892754 AP2M1 -0.7 -6.1 -0.32 2.96e-9 Cognitive function; CRC cis rs4234798 0.546 rs4689667 chr4:7249188 A/T cg18431297 chr4:7219810 SORCS2 -0.5 -8.21 -0.41 4.96e-15 Insulin-like growth factors; CRC cis rs13256369 1.000 rs883648 chr8:8569521 A/G cg06636001 chr8:8085503 FLJ10661 0.5 6.32 0.33 8.52e-10 Obesity-related traits; CRC cis rs736408 0.609 rs2230534 chr3:52802402 A/C cg18099408 chr3:52552593 STAB1 -0.45 -7.3 -0.37 2.12e-12 Bipolar disorder; CRC cis rs7666738 0.830 rs2019163 chr4:99022747 C/T cg17366294 chr4:99064904 C4orf37 0.43 7.29 0.37 2.28e-12 Colonoscopy-negative controls vs population controls; CRC cis rs1577917 0.771 rs2842612 chr6:86303091 G/A cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.67 -8.79 -0.44 8.78e-17 Response to antipsychotic treatment; CRC cis rs9611565 0.765 rs132920 chr22:41810170 T/C cg03806693 chr22:41940476 POLR3H 0.99 12.49 0.57 1.47e-29 Vitiligo; CRC trans rs11148252 0.840 rs56304200 chr13:52781763 T/A cg18335740 chr13:41363409 SLC25A15 0.54 8.33 0.42 2.22e-15 Lewy body disease; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg21655969 chr15:90792609 TTLL13 0.34 5.99 0.31 5.36e-9 Liver disease severity in Alagille syndrome; CRC cis rs7586879 0.789 rs67221599 chr2:25131948 T/C cg04586622 chr2:25135609 ADCY3 -0.58 -9.75 -0.47 6.53e-20 Body mass index; CRC cis rs10256972 0.684 rs2363279 chr7:1096143 A/G cg02869364 chr7:1081709 C7orf50 -0.36 -5.61 -0.3 4.24e-8 Longevity;Endometriosis; CRC cis rs3741151 1.000 rs76764824 chr11:73073580 C/T cg17517138 chr11:73019481 ARHGEF17 1.12 9.63 0.47 1.74e-19 GIP levels in response to oral glucose tolerance test (120 minutes); CRC cis rs4727963 0.740 rs12706479 chr7:122736336 G/A cg03640110 chr7:122635026 TAS2R16 0.35 6.33 0.33 8.19e-10 Adverse response to chemotherapy (neutropenia/leucopenia) (docetaxel); CRC cis rs853679 0.517 rs1947862 chr6:28105196 C/T cg25164649 chr6:28176230 NA 0.76 9.56 0.47 2.82e-19 Depression; CRC cis rs2019137 0.539 rs6755040 chr2:113981137 T/C cg01577475 chr2:114033581 PAX8;LOC440839 -0.24 -6.15 -0.32 2.23e-9 Lymphocyte counts; CRC cis rs10504229 0.906 rs58559296 chr8:58171714 T/C cg24829409 chr8:58192753 C8orf71 -0.68 -11.34 -0.53 2.27e-25 Developmental language disorder (linguistic errors); CRC cis rs9818758 0.607 rs71324929 chr3:49044713 C/T cg00383909 chr3:49044727 WDR6 1.36 12.4 0.56 3.13e-29 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; CRC cis rs8062405 0.755 rs12447461 chr16:28582941 C/A cg16576597 chr16:28551801 NUPR1 0.55 8.11 0.41 1.05e-14 Cognitive ability (multi-trait analysis);Cognitive ability; CRC cis rs875971 0.895 rs6460278 chr7:65662736 T/C cg12463550 chr7:65579703 CRCP -0.5 -6.75 -0.35 6.76e-11 Aortic root size; CRC cis rs1003719 0.523 rs1063949 chr21:38574675 T/C cg10648535 chr21:38446584 PIGP;TTC3 -0.45 -6.23 -0.32 1.41e-9 Eye color traits; CRC cis rs8017423 0.630 rs4900038 chr14:90821677 A/G cg14092571 chr14:90743983 NA 0.39 5.97 0.31 6.31e-9 Mortality in heart failure; CRC cis rs2361718 0.500 rs8064429 chr17:78096187 A/C cg08347473 chr17:78092826 GAA -0.33 -5.64 -0.3 3.73e-8 Yeast infection; CRC cis rs782590 0.818 rs2627782 chr2:55825352 A/G cg18811423 chr2:55921094 PNPT1 0.79 13.91 0.61 6.74e-35 Metabolic syndrome; CRC cis rs55702914 0.775 rs17405686 chr2:198241861 A/G cg10820045 chr2:198174542 NA 0.37 6.54 0.34 2.38e-10 Major depression and alcohol dependence; CRC cis rs9549328 0.542 rs36172983 chr13:113616582 T/C cg08614441 chr13:113633676 MCF2L 0.4 6.97 0.36 1.69e-11 Systolic blood pressure; CRC cis rs3091242 0.933 rs11802413 chr1:25760920 A/G cg20684491 chr1:25596433 NA -0.43 -7.49 -0.38 6.29e-13 Erythrocyte sedimentation rate; CRC cis rs7811142 0.943 rs73403312 chr7:100024153 T/C cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.74 10.28 0.49 1.11e-21 Platelet count; CRC cis rs1499614 1.000 rs1267817 chr7:66110040 G/T cg18252515 chr7:66147081 NA -1.26 -14.98 -0.64 4.69e-39 Gout; CRC trans rs916888 0.610 rs199453 chr17:44800946 C/T cg22433210 chr17:43662623 NA 0.6 7.36 0.38 1.47e-12 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs2243480 1.000 rs2257790 chr7:65600450 C/T cg12463550 chr7:65579703 CRCP 0.7 6.48 0.34 3.32e-10 Diabetic kidney disease; CRC cis rs9322193 0.962 rs4552 chr6:150132319 A/T cg13206674 chr6:150067644 NUP43 0.57 8.17 0.41 6.87e-15 Lung cancer; CRC cis rs7937682 0.632 rs10891294 chr11:111699224 C/T cg09085632 chr11:111637200 PPP2R1B 0.95 15.07 0.64 2.16e-39 Primary sclerosing cholangitis; CRC cis rs10197940 0.662 rs2432945 chr2:152278414 T/C cg19508488 chr2:152266495 RIF1 0.52 7.65 0.39 2.2e-13 Lung cancer; CRC cis rs10504229 1.000 rs59797486 chr8:58174435 T/C cg22535103 chr8:58192502 C8orf71 -0.75 -11.55 -0.54 3.78e-26 Developmental language disorder (linguistic errors); CRC cis rs6968419 0.674 rs7459355 chr7:115906775 A/G cg02561103 chr7:115862891 TES -0.43 -6.42 -0.33 4.81e-10 Intraocular pressure; CRC cis rs7587476 0.861 rs3768716 chr2:215635794 T/C cg04004882 chr2:215674386 BARD1 0.58 6.62 0.34 1.48e-10 Neuroblastoma; CRC cis rs12476592 0.602 rs2166497 chr2:63800159 C/T cg10828910 chr2:63850056 LOC388955 0.49 6.11 0.32 2.79e-9 Childhood ear infection; CRC cis rs9311474 0.629 rs7636227 chr3:52566682 G/A cg10802521 chr3:52805072 NEK4 -0.41 -6.47 -0.34 3.62e-10 Electroencephalogram traits; CRC cis rs2404602 0.647 rs7165053 chr15:76978918 A/G cg03037974 chr15:76606532 NA -0.52 -7.9 -0.4 4.26e-14 Blood metabolite levels; CRC cis rs9747201 0.862 rs11651738 chr17:80178691 A/T cg14673194 chr17:80132900 CCDC57 -0.46 -5.86 -0.31 1.12e-8 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs763121 0.853 rs4821816 chr22:39113134 G/A cg06022373 chr22:39101656 GTPBP1 0.8 13.09 0.59 8.61e-32 Menopause (age at onset); CRC trans rs7613875 0.580 rs3774745 chr3:50204745 C/T cg21665057 chr3:196295764 WDR53;FBXO45 -0.5 -7.91 -0.4 4.07e-14 Body mass index; CRC cis rs11122272 0.735 rs11122279 chr1:231519804 A/G cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.54 -8.09 -0.41 1.18e-14 Hemoglobin concentration; CRC cis rs34375054 0.573 rs12811438 chr12:125653490 C/T cg02766259 chr12:125626809 AACS -0.44 -6.1 -0.32 3.02e-9 Post bronchodilator FEV1/FVC ratio; CRC cis rs539514 0.690 rs1924214 chr13:76317632 A/G cg04757411 chr13:76259545 LMO7 -0.34 -5.78 -0.3 1.74e-8 Type 1 diabetes; CRC cis rs208520 1.000 rs12193164 chr6:66978962 C/T cg07460842 chr6:66804631 NA 0.91 11.17 0.52 8.75e-25 Exhaled nitric oxide output; CRC cis rs6964587 0.597 rs975707 chr7:91874527 C/G cg17063962 chr7:91808500 NA 0.57 8.92 0.44 3.42e-17 Breast cancer; CRC cis rs25422 0.938 rs7356858 chr6:118765814 G/C cg22561889 chr6:118971681 C6orf204 0.53 6.87 0.35 3.16e-11 Renal cell carcinoma; CRC cis rs4727027 0.865 rs12154368 chr7:148862041 C/T cg12479418 chr7:148823350 ZNF425;ZNF398 0.42 5.75 0.3 2e-8 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC cis rs28386778 0.863 rs894414 chr17:61916384 T/C cg23090583 chr17:61904693 PSMC5;FTSJ3 1.05 20.55 0.75 5.84e-61 Prudent dietary pattern; CRC cis rs7259376 1.000 rs7259376 chr19:22507705 C/T cg02657401 chr19:22469223 NA 0.37 8.29 0.42 2.89e-15 Menopause (age at onset); CRC cis rs12580194 0.556 rs73119000 chr12:55736662 G/A cg19537932 chr12:55886519 OR6C68 -0.65 -8.42 -0.42 1.16e-15 Cancer; CRC cis rs2836974 0.897 rs35064900 chr21:40555492 A/G cg17971929 chr21:40555470 PSMG1 0.87 13.1 0.59 7.35e-32 Cognitive function; CRC cis rs6502050 0.835 rs10163496 chr17:80110867 G/A cg09264619 chr17:80180166 NA -0.34 -5.81 -0.3 1.5e-8 Life satisfaction; CRC cis rs12541635 0.677 rs7819501 chr8:107006962 C/T cg10147462 chr8:107024639 NA -0.59 -9.85 -0.48 3.03e-20 Age of smoking initiation; CRC cis rs561341 0.660 rs7406043 chr17:30220152 C/G cg19193384 chr17:30244184 NA -0.52 -6.28 -0.33 1.1e-9 Hip circumference adjusted for BMI; CRC cis rs736408 0.736 rs4687550 chr3:52823430 T/G cg10802521 chr3:52805072 NEK4 -0.49 -6.93 -0.36 2.24e-11 Bipolar disorder; CRC cis rs9611565 0.559 rs5758397 chr22:42019251 C/T cg06634786 chr22:41940651 POLR3H 0.61 6.5 0.34 2.99e-10 Vitiligo; CRC cis rs4713118 0.869 rs9393851 chr6:27699581 A/T cg20933634 chr6:27740509 NA 0.58 8.5 0.42 6.74e-16 Parkinson's disease; CRC cis rs11098499 0.754 rs9991959 chr4:120253773 C/T cg09307838 chr4:120376055 NA -0.6 -9.46 -0.46 6.04e-19 Corneal astigmatism; CRC cis rs3736485 0.844 rs4774591 chr15:51770185 T/C cg08986416 chr15:51914746 DMXL2 -0.46 -6.55 -0.34 2.18e-10 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs9902453 0.838 rs9646438 chr17:28209091 C/T cg26525008 chr17:28256777 EFCAB5;SSH2 0.59 8.81 0.44 7.18e-17 Coffee consumption (cups per day); CRC cis rs3750082 0.889 rs4437549 chr7:32914965 C/T cg05721444 chr7:32995514 FKBP9 0.51 7.87 0.4 5.33e-14 Glomerular filtration rate (creatinine); CRC cis rs10751667 0.600 rs10902264 chr11:1003523 G/A cg23136738 chr11:925521 AP2A2 -0.4 -6.24 -0.33 1.34e-9 Alzheimer's disease (late onset); CRC cis rs713477 0.524 rs4901560 chr14:55888533 C/T cg13175173 chr14:55914753 NA 0.51 8.26 0.41 3.64e-15 Pediatric bone mineral content (femoral neck); CRC cis rs1348850 0.668 rs2365619 chr2:178497366 A/G cg22681709 chr2:178499509 PDE11A 0.36 5.86 0.31 1.11e-8 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg05000123 chr14:20937394 PNP 0.52 6.85 0.35 3.69e-11 Thyroid stimulating hormone; CRC cis rs7666738 0.962 rs2865950 chr4:99040061 T/C cg17366294 chr4:99064904 C4orf37 0.46 7.39 0.38 1.25e-12 Colonoscopy-negative controls vs population controls; CRC cis rs7618915 0.547 rs4687638 chr3:52651966 A/C cg08222913 chr3:52553049 STAB1 -0.34 -6.08 -0.32 3.35e-9 Bipolar disorder; CRC cis rs763121 0.819 rs3747173 chr22:39069045 A/G cg06022373 chr22:39101656 GTPBP1 0.8 12.62 0.57 4.84e-30 Menopause (age at onset); CRC cis rs12477438 0.765 rs9710648 chr2:99673129 A/C cg14399236 chr2:99771627 LIPT1;TSGA10 -0.6 -8.19 -0.41 6.03e-15 Chronic sinus infection; CRC cis rs2239547 0.657 rs12496077 chr3:52886241 G/A cg10802521 chr3:52805072 NEK4 -0.46 -6.16 -0.32 2.11e-9 Schizophrenia; CRC cis rs9611565 0.625 rs12483991 chr22:41935285 A/G cg03806693 chr22:41940476 POLR3H -0.91 -12.21 -0.56 1.58e-28 Vitiligo; CRC cis rs6500602 0.727 rs11076836 chr16:4569331 G/A cg08645402 chr16:4508243 NA 0.64 11.34 0.53 2.3e-25 Schizophrenia; CRC trans rs10983614 1.000 rs7867776 chr9:120072627 A/G cg19590674 chr17:25783100 NA 0.48 6.58 0.34 1.81e-10 Survival in pancreatic cancer; CRC cis rs6500602 0.727 rs11076836 chr16:4569331 G/A cg14951292 chr16:4525986 HMOX2;NMRAL1 0.55 8.36 0.42 1.84e-15 Schizophrenia; CRC cis rs887829 0.569 rs7574296 chr2:234638249 A/G cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.51 -8.3 -0.42 2.8e-15 Metabolic traits;Bilirubin levels;Cholelithiasis-related traits in sickle cell anemia;Metabolite levels;Total bilirubin levels in HIV-1 infection;Serum metabolite levels;Blood metabolite levels; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg23926253 chr19:19303735 LOC729991-MEF2B;LOC729991;RFXANK 0.44 6.05 0.32 4.04e-9 Anxiety disorder; CRC cis rs2239547 0.603 rs2276825 chr3:52886605 T/C cg11645453 chr3:52864694 ITIH4 0.59 10.42 0.5 3.82e-22 Schizophrenia; CRC cis rs965469 0.948 rs2236094 chr20:3260368 C/G cg25506879 chr20:3388711 C20orf194 0.38 5.62 0.3 4.14e-8 IFN-related cytopenia; CRC cis rs875971 0.895 rs6460300 chr7:65952924 A/G cg18876405 chr7:65276391 NA 0.52 8.9 0.44 3.86e-17 Aortic root size; CRC cis rs4713118 0.547 rs2116981 chr6:28067951 T/G cg06470822 chr6:28175283 NA 1.0 13.33 0.59 1.04e-32 Parkinson's disease; CRC cis rs11628318 0.614 rs62007925 chr14:103128288 G/A cg08075719 chr14:103021372 NA 0.65 7.55 0.38 4.22e-13 Platelet count; CRC cis rs2832191 0.671 rs2832212 chr21:30511417 G/A cg08807101 chr21:30365312 RNF160 -0.52 -7.24 -0.37 3.16e-12 Dental caries; CRC cis rs10870270 1.000 rs7077744 chr10:133770201 C/T cg17892150 chr10:133769511 PPP2R2D -0.74 -10.97 -0.52 4.45e-24 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; CRC cis rs10256972 0.553 rs4236381 chr7:1165723 A/C cg03923535 chr7:1197113 ZFAND2A 0.66 9.25 0.45 2.97e-18 Longevity;Endometriosis; CRC trans rs7821565 0.904 rs72636537 chr8:52163430 G/A cg09187163 chr7:72721838 NSUN5 -0.41 -6.07 -0.32 3.61e-9 Tuberculosis; CRC trans rs10242455 1.000 rs17161692 chr7:98953863 A/G cg04001138 chr6:49514721 NA 0.59 5.98 0.31 5.68e-9 Blood metabolite levels; CRC cis rs7937682 0.593 rs4598705 chr11:111345840 G/A cg09085632 chr11:111637200 PPP2R1B 0.42 5.79 0.3 1.61e-8 Primary sclerosing cholangitis; CRC trans rs66573146 1.000 rs7686168 chr4:6986057 C/A cg07817883 chr1:32538562 TMEM39B 1.51 13.4 0.59 5.67e-33 Granulocyte percentage of myeloid white cells; CRC cis rs2404602 0.716 rs12917430 chr15:76674360 T/C cg23625390 chr15:77176239 SCAPER 0.51 7.6 0.39 3.12e-13 Blood metabolite levels; CRC cis rs11997175 0.646 rs7464237 chr8:33716596 C/T ch.8.33884649F chr8:33765107 NA 0.45 6.55 0.34 2.26e-10 Body mass index; CRC cis rs17401966 0.838 rs12139981 chr1:10390696 T/C cg19773385 chr1:10388646 KIF1B -0.67 -10.84 -0.51 1.29e-23 Hepatocellular carcinoma; CRC cis rs116095464 0.614 rs10067482 chr5:219328 T/G cg22496380 chr5:211416 CCDC127 -0.83 -9.55 -0.47 3.03e-19 Breast cancer; CRC cis rs60843830 1.000 rs55753056 chr2:243929 G/A cg25945732 chr2:264204 ACP1;SH3YL1 0.73 12.1 0.55 3.97e-28 Spherical equivalent (joint analysis main effects and education interaction); CRC trans rs9956878 0.555 rs8085188 chr18:73544676 A/G cg09097040 chr12:68726427 MDM1 -0.39 -6.41 -0.33 5.08e-10 Obesity-related traits; CRC cis rs6952808 0.542 rs10243920 chr7:1950385 G/A cg02951883 chr7:2050386 MAD1L1 -0.54 -8.86 -0.44 5.03e-17 Bipolar disorder and schizophrenia; CRC cis rs12410462 0.901 rs1120000 chr1:227659615 T/C cg04117972 chr1:227635322 NA 0.55 6.4 0.33 5.39e-10 Major depressive disorder; CRC cis rs9534288 0.797 rs2182482 chr13:46582654 T/A cg15192986 chr13:46630673 CPB2 -0.67 -9.85 -0.48 3.16e-20 Blood protein levels; CRC cis rs9443645 0.869 rs11754419 chr6:79729648 A/G cg11833968 chr6:79620685 NA -0.36 -6.22 -0.32 1.5e-9 Intelligence (multi-trait analysis); CRC cis rs4319547 0.695 rs10773103 chr12:122856532 A/G cg23029597 chr12:123009494 RSRC2 0.59 7.21 0.37 3.98e-12 Body mass index; CRC cis rs477692 0.544 rs7904404 chr10:131447612 G/A cg05714579 chr10:131428358 MGMT -0.84 -12.9 -0.58 4.49e-31 Response to temozolomide; CRC cis rs6860806 0.507 rs274570 chr5:131713226 C/T cg18758796 chr5:131593413 PDLIM4 -0.4 -6.45 -0.34 3.99e-10 Breast cancer; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg25969087 chr8:101733612 PABPC1 0.46 6.3 0.33 9.43e-10 Anxiety disorder; CRC trans rs9825823 0.617 rs2083264 chr3:61074229 A/G cg02548606 chr15:77363299 TSPAN3 0.43 5.96 0.31 6.42e-9 Depressive symptom measurement or major depressive disorder; CRC cis rs10911251 0.528 rs2147584 chr1:183074764 T/C ch.1.3577855R chr1:183094577 LAMC1 0.87 15.49 0.65 5.14e-41 Colorectal cancer; CRC cis rs35306767 0.855 rs12771179 chr10:872347 A/G cg20503657 chr10:835505 NA 1.23 15.05 0.64 2.68e-39 Eosinophil percentage of granulocytes; CRC cis rs6479527 0.806 rs1933668 chr9:96743773 A/G cg14459158 chr9:96720562 NA -0.4 -7.28 -0.37 2.42e-12 Esophageal adenocarcinoma; CRC cis rs501120 0.564 rs11238904 chr10:44684707 C/T cg09554077 chr10:44749378 NA 0.55 7.62 0.39 2.81e-13 Coronary artery disease;Coronary heart disease; CRC cis rs3540 0.597 rs10152221 chr15:91047664 A/G cg22089800 chr15:90895588 ZNF774 -0.57 -9.51 -0.46 4.22e-19 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; CRC cis rs858239 0.676 rs274032 chr7:23374559 C/G cg00469287 chr7:23338798 C7orf30 0.44 6.02 0.31 4.74e-9 Cerebrospinal fluid biomarker levels; CRC cis rs2991971 0.903 rs2991973 chr1:46020632 G/A cg03123370 chr1:45965343 CCDC163P;MMACHC -0.4 -5.94 -0.31 7.08e-9 High light scatter reticulocyte count; CRC cis rs910316 0.763 rs175042 chr14:75470833 A/T cg03030879 chr14:75389066 RPS6KL1 0.4 6.02 0.32 4.56e-9 Height; CRC cis rs9914544 1.000 rs67411574 chr17:18797337 A/G cg26378065 chr17:18585709 ZNF286B 0.42 5.82 0.31 1.39e-8 Educational attainment (years of education); CRC cis rs7572644 0.679 rs4419196 chr2:28075298 A/G cg27432699 chr2:27873401 GPN1 0.43 5.98 0.31 5.68e-9 Response to carboplatin and paclitaxel in ovarian cancer (Caspase 3/7 EC50); CRC cis rs2303759 0.918 rs10405465 chr19:49869298 C/T cg24324837 chr19:49891574 CCDC155 0.54 7.85 0.4 5.83e-14 Multiple sclerosis; CRC cis rs4867766 0.871 rs113284505 chr5:173954800 A/G cg20434911 chr5:173954559 NA -0.78 -9.35 -0.46 1.34e-18 Stroke; CRC cis rs3749237 0.964 rs2234385 chr3:49846041 G/A cg03060546 chr3:49711283 APEH 0.42 6.3 0.33 9.44e-10 Resting heart rate; CRC cis rs28386778 0.897 rs9913323 chr17:61851485 C/A cg06601766 chr17:61851465 DDX42;CCDC47 0.43 5.92 0.31 7.91e-9 Prudent dietary pattern; CRC cis rs8072100 0.967 rs7221548 chr17:45582952 T/C cg25173405 chr17:45401733 C17orf57 0.46 7.23 0.37 3.38e-12 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs11148252 0.875 rs4885953 chr13:52976491 G/A cg02158880 chr13:53174818 NA 0.41 6.14 0.32 2.42e-9 Lewy body disease; CRC cis rs10504229 0.593 rs17192845 chr8:58053339 C/T cg20607798 chr8:58055168 NA 0.55 6.15 0.32 2.26e-9 Developmental language disorder (linguistic errors); CRC cis rs6088590 0.687 rs73106933 chr20:33287425 T/C cg24642439 chr20:33292090 TP53INP2 0.47 8.2 0.41 5.29e-15 Coronary artery disease; CRC cis rs4713675 0.565 rs942640 chr6:33686442 G/T cg14003231 chr6:33640908 ITPR3 0.49 8.01 0.4 1.98e-14 Plateletcrit; CRC trans rs4650994 0.525 rs2493848 chr1:178547838 T/A cg05059571 chr16:84539110 KIAA1609 0.57 7.85 0.4 6.02e-14 HDL cholesterol levels;HDL cholesterol; CRC trans rs7267979 1.000 rs2258769 chr20:25276680 G/C cg17903999 chr18:56338584 MALT1 -0.42 -7.08 -0.36 8.6e-12 Liver enzyme levels (alkaline phosphatase); CRC cis rs1862618 0.671 rs906631 chr5:56245803 C/G cg12311346 chr5:56204834 C5orf35 0.64 9.72 0.47 8.47e-20 Initial pursuit acceleration; CRC cis rs7618915 0.547 rs2268027 chr3:52766606 G/A cg08222913 chr3:52553049 STAB1 -0.33 -6.02 -0.31 4.78e-9 Bipolar disorder; CRC cis rs10504229 1.000 rs66731170 chr8:58187895 C/G cg02290350 chr8:58132656 NA -0.42 -5.96 -0.31 6.62e-9 Developmental language disorder (linguistic errors); CRC cis rs59104589 0.617 rs16843671 chr2:242374358 T/C cg19488206 chr2:242435732 STK25 0.49 7.12 0.37 6.65e-12 Fibrinogen levels; CRC cis rs4713118 0.662 rs149900 chr6:28014597 C/T cg02683197 chr6:28174875 NA 0.71 9.27 0.46 2.55e-18 Parkinson's disease; CRC cis rs11764590 0.715 rs55770986 chr7:2087823 T/C cg02421172 chr7:1938701 MAD1L1 0.42 5.64 0.3 3.61e-8 Neuroticism; CRC cis rs9911578 0.813 rs8066773 chr17:56601552 A/G cg12560992 chr17:57184187 TRIM37 0.86 14.03 0.61 2.24e-35 Intelligence (multi-trait analysis); CRC cis rs769267 0.965 rs13964 chr19:19468710 C/G cg01262667 chr19:19385393 TM6SF2 -0.37 -6.12 -0.32 2.69e-9 Tonsillectomy; CRC cis rs1799949 1.000 rs33920795 chr17:41329010 A/G cg25072359 chr17:41440525 NA 0.46 6.91 0.36 2.52e-11 Menopause (age at onset); CRC cis rs9614461 0.826 rs9614649 chr22:45746097 C/A cg15911859 chr22:45810043 RIBC2;SMC1B 0.63 6.63 0.34 1.39e-10 Tonsillectomy; CRC cis rs611744 0.647 rs7015513 chr8:109262570 A/C cg18478394 chr8:109455254 TTC35 0.39 5.95 0.31 6.73e-9 Dupuytren's disease; CRC cis rs7527798 0.592 rs6657161 chr1:207847128 C/T cg09232269 chr1:207846808 CR1L -0.5 -7.82 -0.4 7.03e-14 Erythrocyte sedimentation rate; CRC cis rs6764363 0.527 rs7650973 chr3:276196 A/G cg02057681 chr3:285234 CHL1 0.39 6.68 0.35 1.05e-10 Sudden cardiac arrest; CRC cis rs123509 0.913 rs339661 chr3:42753904 G/A cg12982090 chr3:42733453 KBTBD5 0.56 7.26 0.37 2.74e-12 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs3858526 0.628 rs1840177 chr11:5944627 T/G cg25319279 chr11:5960081 NA 0.36 6.17 0.32 1.99e-9 DNA methylation (variation); CRC cis rs58688157 0.705 rs936469 chr11:606749 G/A cg11503833 chr11:492997 NA 0.44 5.63 0.3 3.81e-8 Systemic lupus erythematosus; CRC cis rs853679 0.550 rs1233704 chr6:28166923 A/G cg03623178 chr6:28175578 NA -1.01 -15.74 -0.66 5.29e-42 Depression; CRC cis rs4862750 0.832 rs6836076 chr4:187899660 A/C cg03647317 chr4:187891568 NA -0.54 -10.28 -0.49 1.09e-21 Lobe attachment (rater-scored or self-reported); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg09019432 chr17:62503014 CCDC45;DDX5 0.44 6.13 0.32 2.5e-9 Response to antipsychotic treatment; CRC cis rs9361491 0.657 rs4706730 chr6:79467903 C/T cg09184832 chr6:79620586 NA -0.33 -5.9 -0.31 9.22e-9 Intelligence (multi-trait analysis); CRC cis rs9487051 0.768 rs371960 chr6:109525082 A/G cg01475377 chr6:109611718 NA -0.36 -6.35 -0.33 6.99e-10 Reticulocyte fraction of red cells; CRC cis rs2742417 0.587 rs2742375 chr3:45784602 G/A cg04837898 chr3:45731254 SACM1L -0.47 -7.58 -0.39 3.6e-13 Response to anti-depressant treatment in major depressive disorder; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg03337784 chr13:41768818 KBTBD7 0.43 6.02 0.31 4.55e-9 Response to antipsychotic treatment; CRC cis rs17270561 0.609 rs9358873 chr6:25731783 C/T cg16482183 chr6:26056742 HIST1H1C 0.85 10.66 0.51 5.33e-23 Iron status biomarkers; CRC trans rs2303319 0.504 rs62189046 chr2:162612371 C/G cg25193742 chr10:104614220 C10orf32 -0.77 -6.51 -0.34 2.87e-10 Cognitive function; CRC cis rs1355223 0.573 rs7125773 chr11:34723573 A/G cg11058730 chr11:34937778 PDHX;APIP -0.43 -5.62 -0.3 4e-8 Systemic lupus erythematosus and Systemic sclerosis; CRC cis rs9747201 1.000 rs56283054 chr17:80135326 C/T cg14673194 chr17:80132900 CCDC57 0.48 6.19 0.32 1.78e-9 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs801193 0.569 rs2659908 chr7:66160822 G/A cg11764359 chr7:65958608 NA 0.59 8.87 0.44 4.85e-17 Aortic root size; CRC cis rs28386778 0.897 rs2727287 chr17:61904728 G/A cg07362569 chr17:61921086 SMARCD2 0.39 6.02 0.31 4.7e-9 Prudent dietary pattern; CRC cis rs860295 0.812 rs4278368 chr1:155722557 G/A cg02153340 chr1:155202674 NA -0.52 -6.46 -0.34 3.71e-10 Body mass index; CRC cis rs2404602 0.611 rs2404734 chr15:76936165 T/C cg03037974 chr15:76606532 NA -0.5 -7.26 -0.37 2.81e-12 Blood metabolite levels; CRC cis rs1971762 0.527 rs7300936 chr12:54030586 C/T cg06632207 chr12:54070931 ATP5G2 0.49 8.48 0.42 7.63e-16 Height; CRC cis rs2239547 0.522 rs2581797 chr3:52972468 C/T cg15147215 chr3:52552868 STAB1 0.38 5.76 0.3 1.98e-8 Schizophrenia; CRC cis rs72781680 0.593 rs72797817 chr2:24350569 A/G cg20701182 chr2:24300061 SF3B14 0.58 7.06 0.36 9.73e-12 Lymphocyte counts; CRC cis rs7666738 0.962 rs2865991 chr4:99067369 C/A cg03676636 chr4:99064102 C4orf37 0.21 5.84 0.31 1.22e-8 Colonoscopy-negative controls vs population controls; CRC cis rs3806843 0.868 rs2262574 chr5:140123635 G/T cg19875535 chr5:140030758 IK -0.51 -8.26 -0.41 3.68e-15 Depressive symptoms (multi-trait analysis); CRC cis rs7617773 0.963 rs6766754 chr3:48182589 T/C cg11946769 chr3:48343235 NME6 -0.47 -6.71 -0.35 8.55e-11 Coronary artery disease; CRC cis rs8070740 0.898 rs4790770 chr17:5324893 A/C cg25236894 chr17:5323110 RPAIN;NUP88 0.48 7.5 0.38 5.95e-13 Menopause (age at onset); CRC cis rs17095355 1.000 rs72828245 chr10:111746596 G/T cg00817464 chr10:111662876 XPNPEP1 -0.61 -8.36 -0.42 1.75e-15 Biliary atresia; CRC cis rs6860806 0.661 rs6890009 chr5:131580033 G/T cg11843238 chr5:131593191 PDLIM4 0.42 8.03 0.4 1.71e-14 Breast cancer; CRC cis rs2842992 0.830 rs2025190 chr6:160138241 C/T cg19482086 chr6:160211437 TCP1;MRPL18 0.74 9.15 0.45 6.16e-18 Age-related macular degeneration (geographic atrophy); CRC trans rs61931739 0.500 rs11519123 chr12:34436478 A/G cg26384229 chr12:38710491 ALG10B 0.61 8.99 0.44 2.05e-17 Morning vs. evening chronotype; CRC trans rs13046373 0.905 rs4816372 chr21:32077414 A/T cg05818854 chr2:71295273 NAGK -0.43 -6.27 -0.33 1.11e-9 HDL cholesterol; CRC cis rs2204008 0.543 rs2387018 chr12:38065638 C/T cg26384229 chr12:38710491 ALG10B 0.68 9.15 0.45 6.07e-18 Bladder cancer; CRC cis rs17234274 0.549 rs4922644 chr11:23233709 G/A cg05245346 chr11:23248277 NA 0.35 5.66 0.3 3.29e-8 Cancer; CRC cis rs5760092 0.572 rs738806 chr22:24234172 A/G cg00024416 chr22:24240387 NA -0.47 -6.49 -0.34 3.1e-10 Urinary 1,3-butadiene metabolite levels in smokers; CRC trans rs9393777 0.920 rs13195040 chr6:27413924 C/T cg06606381 chr12:133084897 FBRSL1 1.06 7.31 0.37 2.05e-12 Intelligence (multi-trait analysis); CRC cis rs5769707 0.521 rs9616715 chr22:50058582 C/T cg20744362 chr22:50050164 C22orf34 0.32 5.82 0.31 1.38e-8 Monocyte count;Monocyte percentage of white cells; CRC cis rs4665809 0.618 rs7579199 chr2:26266496 G/A cg27170947 chr2:26402098 FAM59B -0.44 -5.83 -0.31 1.32e-8 Gut microbiome composition (summer); CRC trans rs6600671 1.000 rs10903159 chr1:121181997 G/T cg00646200 chr1:148855367 NA 0.34 6.22 0.32 1.49e-9 Hip geometry; CRC cis rs523522 0.962 rs509445 chr12:121017243 A/C cg12219531 chr12:120966889 COQ5 0.69 9.12 0.45 7.92e-18 High light scatter reticulocyte count; CRC cis rs6908843 0.532 rs79555858 chr6:166666497 G/A cg06878426 chr6:166666287 NA 0.56 6.06 0.32 3.67e-9 Macrophage inflammatory protein 1b levels; CRC cis rs611744 0.506 rs4735054 chr8:109261780 A/C cg21045802 chr8:109455806 TTC35 -0.46 -7.19 -0.37 4.39e-12 Dupuytren's disease; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg07491357 chr18:9914943 VAPA 0.48 6.6 0.34 1.66e-10 Response to antipsychotic treatment; CRC cis rs561341 1.000 rs530715 chr17:30320544 T/G cg23018236 chr17:30244563 NA -0.58 -7.7 -0.39 1.64e-13 Hip circumference adjusted for BMI; CRC cis rs2559856 1.000 rs2695288 chr12:102088112 T/C cg12924262 chr12:102091054 CHPT1 0.55 8.23 0.41 4.43e-15 Blood protein levels; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg10893370 chr17:30228961 UTP6 0.44 6.23 0.32 1.43e-9 Response to antipsychotic treatment; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg25048357 chr11:118955763 HMBS 0.42 6.11 0.32 2.84e-9 Intelligence (multi-trait analysis); CRC cis rs2302190 0.882 rs3809709 chr17:56590559 C/T cg12560992 chr17:57184187 TRIM37 0.52 6.11 0.32 2.81e-9 Vitamin D levels; CRC cis rs854765 0.547 rs4584886 chr17:17896205 C/T cg24612305 chr17:17875800 TOM1L2;LRRC48 0.73 13.54 0.6 1.73e-33 Total body bone mineral density; CRC cis rs9547692 1.000 rs1328042 chr13:37466947 G/A cg01493522 chr13:37497338 NA -0.52 -7.16 -0.37 5.21e-12 Coronary artery disease; CRC cis rs10504229 0.681 rs11779172 chr8:58045538 A/G cg02725872 chr8:58115012 NA -0.41 -6.33 -0.33 8.11e-10 Developmental language disorder (linguistic errors); CRC cis rs4975616 0.869 rs465498 chr5:1325803 A/G cg26373071 chr5:1325741 CLPTM1L 0.54 9.8 0.48 4.62e-20 Lung cancer; CRC cis rs6951245 0.554 rs75075857 chr7:1140298 C/T cg24642844 chr7:1081250 C7orf50 -0.49 -6.39 -0.33 5.7e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs854572 1.000 rs854572 chr7:94954696 C/G cg19678392 chr7:94953810 PON1 -0.86 -16.0 -0.66 4.9e-43 Paraoxonase activity; CRC cis rs6545883 0.929 rs10200055 chr2:61628017 T/A cg15711740 chr2:61764176 XPO1 0.44 5.85 0.31 1.19e-8 Tuberculosis; CRC cis rs4332037 0.539 rs55773130 chr7:2070554 T/C cg21155852 chr7:2048760 MAD1L1 -0.5 -6.77 -0.35 5.83e-11 Bipolar disorder; CRC cis rs7769051 0.522 rs6930703 chr6:133111266 C/T cg22852734 chr6:133119734 C6orf192 0.83 6.87 0.35 3.31e-11 Type 2 diabetes nephropathy; CRC trans rs561341 0.709 rs8068049 chr17:30183857 T/C cg00801512 chr17:28996047 NA 0.57 6.45 0.34 4.07e-10 Hip circumference adjusted for BMI; CRC cis rs6582630 0.502 rs12815350 chr12:38439921 A/T cg13010199 chr12:38710504 ALG10B 0.47 6.09 0.32 3.16e-9 Drug-induced liver injury (flucloxacillin); CRC cis rs2836974 0.897 rs13049280 chr21:40594656 C/G cg11890956 chr21:40555474 PSMG1 1.03 16.37 0.67 1.72e-44 Cognitive function; CRC cis rs4975616 0.869 rs452384 chr5:1330840 T/C cg06550200 chr5:1325588 CLPTM1L -0.74 -12.24 -0.56 1.22e-28 Lung cancer; CRC cis rs1784581 0.802 rs6455787 chr6:162411378 G/A cg17173639 chr6:162384350 PARK2 0.7 11.45 0.53 8.88e-26 Itch intensity from mosquito bite; CRC cis rs9462846 0.725 rs6927188 chr6:42912589 C/T cg05552183 chr6:42928497 GNMT -0.49 -6.08 -0.32 3.3e-9 Blood protein levels; CRC cis rs7258465 0.965 rs1560118 chr19:18570035 G/A cg06462663 chr19:18546047 ISYNA1 0.47 7.08 0.36 8.6e-12 Breast cancer; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg27482438 chr7:102312200 POLR2J2 0.43 6.07 0.32 3.61e-9 Anxiety disorder; CRC cis rs9733 0.818 rs11204702 chr1:150663507 C/A cg18016565 chr1:150552671 MCL1 -0.42 -6.22 -0.32 1.5e-9 Tonsillectomy; CRC cis rs1707322 0.717 rs11211161 chr1:46148138 A/C cg06784218 chr1:46089804 CCDC17 0.65 12.14 0.56 2.73e-28 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs6933660 0.683 rs6916340 chr6:151779064 T/C cg10883421 chr6:151773342 RMND1;C6orf211 0.81 14.91 0.63 9.46e-39 Menarche (age at onset); CRC cis rs600806 0.850 rs4120621 chr1:109949008 A/G cg23032129 chr1:109941072 SORT1 -0.28 -5.94 -0.31 7.09e-9 Intelligence (multi-trait analysis); CRC cis rs2243480 1.000 rs431318 chr7:65511597 G/A cg25985355 chr7:65971099 NA -0.54 -6.14 -0.32 2.35e-9 Diabetic kidney disease; CRC cis rs2952156 0.920 rs2517955 chr17:37843681 C/T cg20243544 chr17:37824526 PNMT 0.57 9.07 0.45 1.12e-17 Asthma; CRC cis rs2806561 0.704 rs2806570 chr1:23527005 C/T cg12483005 chr1:23474871 LUZP1 -0.5 -7.19 -0.37 4.25e-12 Height; CRC cis rs3809566 1.000 rs3809566 chr15:63333724 A/G cg05507819 chr15:63340323 TPM1 0.44 6.76 0.35 6.36e-11 Platelet count; CRC cis rs12586317 0.557 rs8004288 chr14:35679288 A/G cg07166546 chr14:35805898 NA -0.32 -6.1 -0.32 3.01e-9 Psoriasis; CRC cis rs7618915 0.501 rs3774366 chr3:52641255 T/C cg10802521 chr3:52805072 NEK4 -0.57 -9.11 -0.45 8.49e-18 Bipolar disorder; CRC cis rs7512552 0.839 rs4581308 chr1:150276872 A/G cg15654264 chr1:150340011 RPRD2 -0.58 -7.97 -0.4 2.68e-14 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); CRC cis rs66573146 0.831 rs6832482 chr4:7023433 A/T cg00086871 chr4:6988644 TBC1D14 0.98 8.4 0.42 1.37e-15 Granulocyte percentage of myeloid white cells; CRC cis rs17376456 0.757 rs10066431 chr5:93198204 A/G cg25358565 chr5:93447407 FAM172A 1.06 10.36 0.5 5.88e-22 Diabetic retinopathy; CRC cis rs7909074 1.000 rs12777258 chr10:45394961 A/G cg05187965 chr10:45406764 TMEM72 0.38 8.7 0.43 1.59e-16 Mean corpuscular volume; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg05308161 chr15:59063885 FAM63B 0.42 6.13 0.32 2.45e-9 Intelligence (multi-trait analysis); CRC cis rs9611565 0.840 rs2234059 chr22:41777913 T/C cg06634786 chr22:41940651 POLR3H -0.68 -7.81 -0.4 7.69e-14 Vitiligo; CRC cis rs4731207 0.646 rs67453484 chr7:124454524 T/A cg23710748 chr7:124431027 NA 0.38 5.98 0.31 5.89e-9 Cutaneous malignant melanoma; CRC cis rs1950626 0.671 rs34675695 chr14:101447913 C/T cg02351406 chr14:101447389 SNORD114-20;SNORD114-21 0.97 16.0 0.66 5.06e-43 Pelvic organ prolapse (moderate/severe); CRC cis rs4555082 0.834 rs2816607 chr14:105718385 A/T cg18132624 chr14:105716052 BTBD6;BRF1 -0.51 -8.24 -0.41 4.17e-15 Mean platelet volume;Platelet distribution width; CRC cis rs4727027 0.680 rs6464941 chr7:148826352 A/G cg23583168 chr7:148888333 NA -0.81 -12.03 -0.55 7.24e-28 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC cis rs4076764 0.846 rs12036398 chr1:163422204 C/T cg06092702 chr1:163392909 NA 0.5 7.86 0.4 5.49e-14 Motion sickness; CRC cis rs116095464 0.558 rs7730700 chr5:264713 G/A cg22496380 chr5:211416 CCDC127 -0.91 -10.46 -0.5 2.65e-22 Breast cancer; CRC cis rs4629710 0.592 rs4310080 chr6:131538377 T/G cg12606694 chr6:131520996 AKAP7 0.56 8.41 0.42 1.25e-15 Multiple myeloma (IgH translocation); CRC cis rs8064454 1.000 rs11651755 chr17:36099840 A/G cg04198914 chr17:36106025 HNF1B 0.28 6.01 0.31 4.89e-9 Prostate cancer; CRC cis rs4819052 1.000 rs2297284 chr21:46705345 G/A cg11663144 chr21:46675770 NA -0.77 -11.15 -0.52 1.08e-24 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs12681288 0.676 rs4565481 chr8:1001944 C/T cg15309053 chr8:964076 NA 0.43 7.1 0.36 7.77e-12 Schizophrenia; CRC cis rs4423214 0.840 rs1123007 chr11:71185357 G/A cg05163923 chr11:71159392 DHCR7 -0.63 -7.61 -0.39 2.92e-13 Vitamin D levels; CRC cis rs6445967 1.000 rs9846885 chr3:58285789 C/T cg23715586 chr3:58305044 RPP14 0.36 6.18 0.32 1.89e-9 Platelet count; CRC cis rs501916 0.602 rs472081 chr15:48058652 G/T cg16110827 chr15:48056943 SEMA6D -0.43 -6.59 -0.34 1.73e-10 Inflammatory bowel disease;Ulcerative colitis; CRC cis rs7493 0.950 rs6961624 chr7:95037661 T/C cg01874867 chr7:94954059 PON1 -0.49 -6.36 -0.33 6.6e-10 Yu-Zhi constitution type in type 2 diabetes; CRC trans rs9467711 0.538 rs35942482 chr6:26444938 T/A cg06606381 chr12:133084897 FBRSL1 -0.85 -6.39 -0.33 5.62e-10 Autism spectrum disorder or schizophrenia; CRC cis rs3749237 0.595 rs3924462 chr3:49524236 T/G cg03060546 chr3:49711283 APEH 0.69 11.93 0.55 1.62e-27 Resting heart rate; CRC cis rs394563 0.591 rs237035 chr6:149710848 C/T cg07828024 chr6:149772892 ZC3H12D -0.5 -9.23 -0.45 3.38e-18 Dupuytren's disease; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg04441191 chr3:48130393 MAP4 -0.46 -7.26 -0.37 2.8e-12 Myopia (pathological); CRC cis rs11098499 0.863 rs13134665 chr4:120426430 T/C cg24375607 chr4:120327624 NA 0.47 7.16 0.37 5.26e-12 Corneal astigmatism; CRC cis rs1865760 0.663 rs9348704 chr6:26000393 A/C cg17691542 chr6:26056736 HIST1H1C 0.55 8.7 0.43 1.57e-16 Height; CRC cis rs7647973 0.626 rs62260720 chr3:49853796 T/A cg13072238 chr3:49761600 GMPPB 0.5 5.84 0.31 1.25e-8 Menarche (age at onset); CRC cis rs3820068 0.603 rs6695903 chr1:15985940 C/T cg13390004 chr1:15929781 NA 0.44 6.33 0.33 7.98e-10 Systolic blood pressure; CRC cis rs9322193 0.923 rs9689723 chr6:149977071 C/A cg07701084 chr6:150067640 NUP43 0.56 8.2 0.41 5.44e-15 Lung cancer; CRC cis rs11677416 1.000 rs4848303 chr2:113552698 A/G cg27083787 chr2:113543245 IL1A 0.46 6.25 0.33 1.29e-9 Response to antipsychotic treatment in schizophrenia (working memory); CRC trans rs10242455 0.702 rs7794068 chr7:99146873 A/T cg09045935 chr12:6379348 NA 1.05 8.45 0.42 9.72e-16 Blood metabolite levels; CRC cis rs7584330 0.554 rs77180399 chr2:238442951 G/A cg14458575 chr2:238380390 NA 0.81 10.19 0.49 2.33e-21 Prostate cancer; CRC cis rs10504229 0.683 rs16921810 chr8:58106067 A/G cg22535103 chr8:58192502 C8orf71 -0.69 -8.8 -0.44 7.79e-17 Developmental language disorder (linguistic errors); CRC cis rs7772486 0.790 rs2265918 chr6:146219164 A/G cg13319975 chr6:146136371 FBXO30 -0.41 -6.16 -0.32 2.18e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs1448094 0.512 rs57278040 chr12:86237886 A/G cg25456477 chr12:86230367 RASSF9 0.32 5.6 0.3 4.42e-8 Major depressive disorder; CRC cis rs4132509 0.696 rs10927062 chr1:243889364 A/G cg21452805 chr1:244014465 NA 0.48 6.65 0.34 1.19e-10 RR interval (heart rate); CRC cis rs7781266 0.842 rs4363141 chr7:133225346 C/T cg03336402 chr7:133662267 EXOC4 0.49 5.78 0.3 1.71e-8 Educational attainment (college completion); CRC cis rs7312933 0.669 rs7974476 chr12:42542484 C/A cg11827402 chr12:42719852 PPHLN1;ZCRB1 0.6 8.5 0.42 6.78e-16 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CRC cis rs2276314 0.947 rs3898595 chr18:33565885 T/A cg19628046 chr18:33552617 C18orf21 0.5 6.86 0.35 3.48e-11 Endometriosis;Drug-induced torsades de pointes; CRC cis rs617791 0.508 rs1047464 chr11:65769456 A/T cg09783858 chr11:65769428 EIF1AD;BANF1 0.5 7.62 0.39 2.73e-13 Breast cancer; CRC cis rs9463078 0.630 rs7775717 chr6:44967761 G/A cg25276700 chr6:44698697 NA -0.25 -6.09 -0.32 3.22e-9 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; CRC cis rs877282 0.947 rs957642 chr10:773966 C/T cg17470449 chr10:769945 NA 0.6 8.77 0.44 9.79e-17 Uric acid levels; CRC cis rs6951245 0.554 rs76243429 chr7:1152543 C/T cg23978390 chr7:1156363 C7orf50 0.5 5.63 0.3 3.92e-8 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs1552244 1.000 rs67006488 chr3:10152993 T/C cg18598329 chr3:10140678 FANCD2;C3orf24 -0.89 -11.92 -0.55 1.84e-27 Alzheimer's disease; CRC trans rs6956675 1.000 rs6956675 chr7:62577770 A/G cg01314568 chr7:57830625 NA -0.68 -9.57 -0.47 2.71e-19 Obesity-related traits; CRC cis rs2243480 1.000 rs2465120 chr7:65620974 C/G cg12463550 chr7:65579703 CRCP 0.71 6.52 0.34 2.65e-10 Diabetic kidney disease; CRC cis rs6951245 1.000 rs76804143 chr7:1082021 C/T cg04025307 chr7:1156635 C7orf50 0.64 6.76 0.35 6.29e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs9467711 0.606 rs72836482 chr6:26359241 A/T cg16898833 chr6:26189333 HIST1H4D 0.75 6.55 0.34 2.26e-10 Autism spectrum disorder or schizophrenia; CRC cis rs12024301 0.557 rs11802393 chr1:183654169 T/C cg11505048 chr1:183622726 RGL1;APOBEC4 0.71 6.24 0.33 1.33e-9 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs9443645 0.527 rs2063123 chr6:79658535 T/C cg05283184 chr6:79620031 NA -0.44 -6.33 -0.33 8.18e-10 Intelligence (multi-trait analysis); CRC cis rs11212617 0.967 rs228588 chr11:108113331 C/G cg14761454 chr11:108092087 ATM;NPAT 0.39 5.73 0.3 2.23e-8 Response to metformin in type 2 diabetes (glycemic); CRC cis rs889312 0.500 rs832552 chr5:56113850 A/C cg24531977 chr5:56204891 C5orf35 0.44 6.89 0.36 2.77e-11 Breast cancer;Breast cancer (early onset); CRC cis rs9467711 0.606 rs28360517 chr6:26602453 A/G cg16898833 chr6:26189333 HIST1H4D 0.89 7.39 0.38 1.2e-12 Autism spectrum disorder or schizophrenia; CRC cis rs1568889 1.000 rs7949704 chr11:28373543 A/G cg06544937 chr11:28130018 METT5D1;KIF18A 0.78 10.52 0.5 1.67e-22 Bipolar disorder; CRC cis rs10256972 0.732 rs12701856 chr7:1107707 C/T cg02869364 chr7:1081709 C7orf50 -0.37 -5.61 -0.3 4.32e-8 Longevity;Endometriosis; CRC cis rs79349575 0.783 rs12602933 chr17:47029280 G/C cg00947319 chr17:47005597 UBE2Z -0.33 -5.67 -0.3 3.19e-8 Type 2 diabetes; CRC cis rs1150668 0.699 rs12214383 chr6:28223731 T/C cg03623178 chr6:28175578 NA -0.52 -7.7 -0.39 1.56e-13 Pubertal anthropometrics; CRC cis rs875971 0.505 rs2462573 chr7:65507392 C/T cg00343986 chr7:65444356 GUSB -0.56 -8.5 -0.42 6.79e-16 Aortic root size; CRC cis rs644148 0.867 rs2571060 chr19:44971647 C/G cg15540054 chr19:45004280 ZNF180 -0.69 -9.74 -0.47 7.51e-20 Personality dimensions; CRC trans rs116095464 0.558 rs62346526 chr5:220614 T/C cg00938859 chr5:1591904 SDHAP3 0.68 7.39 0.38 1.24e-12 Breast cancer; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg17173732 chr18:60986891 BCL2 0.44 6.06 0.32 3.74e-9 Thyroid stimulating hormone; CRC cis rs7811142 0.830 rs73401451 chr7:99981895 T/C cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.73 10.01 0.48 9.43e-21 Platelet count; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg11590700 chr3:169381241 MECOM 0.47 7.73 0.39 1.29e-13 Intelligence (multi-trait analysis); CRC cis rs601339 1.000 rs1798219 chr12:123180061 A/C cg22192744 chr12:123187474 GPR109A -0.4 -5.66 -0.3 3.25e-8 Adiponectin levels; CRC cis rs2832077 0.527 rs2250141 chr21:30241984 A/T cg24692254 chr21:30365293 RNF160 0.45 6.48 0.34 3.27e-10 Cognitive test performance; CRC cis rs8099014 0.906 rs4940692 chr18:56099715 A/G cg12907477 chr18:56117327 MIR122 0.46 6.37 0.33 6.2e-10 Platelet count; CRC cis rs10870270 1.000 rs6560694 chr10:133773448 G/A cg08754478 chr10:133766260 PPP2R2D -0.66 -9.28 -0.46 2.34e-18 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; CRC cis rs6541297 1.000 rs2352723 chr1:230291868 C/T cg05784532 chr1:230284198 GALNT2 -0.43 -5.67 -0.3 3.06e-8 Coronary artery disease; CRC cis rs897984 0.513 rs17839568 chr16:31099783 T/C cg02466173 chr16:30829666 NA -0.59 -8.97 -0.44 2.32e-17 Dementia with Lewy bodies; CRC trans rs9784649 1.000 rs3933895 chr5:25004929 A/T cg11038491 chr20:34638489 LOC647979 -0.54 -5.99 -0.31 5.45e-9 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs4713118 0.621 rs9368548 chr6:28034737 A/G cg15845792 chr6:28175446 NA 0.92 12.39 0.56 3.27e-29 Parkinson's disease; CRC cis rs2860975 1.000 rs2860975 chr10:96766934 G/T cg09036531 chr10:96991505 NA 0.43 6.0 0.31 5.23e-9 Immune response to smallpox vaccine (IL-6); CRC cis rs6541297 1.000 rs6682741 chr1:230279090 T/C cg20703242 chr1:230279135 GALNT2 0.51 8.0 0.4 2.18e-14 Coronary artery disease; CRC cis rs12926788 0.689 rs34365165 chr16:24856208 G/A cg02428538 chr16:24856791 SLC5A11 -0.75 -8.81 -0.44 7.42e-17 Ejection fraction in Tripanosoma cruzi seropositivity; CRC cis rs1552244 0.554 rs3732963 chr3:10048885 G/T cg13047869 chr3:10149882 C3orf24 0.39 5.95 0.31 6.8e-9 Alzheimer's disease; CRC trans rs10983614 1.000 rs7867776 chr9:120072627 A/G cg08301299 chr16:2317849 RNPS1 0.49 6.88 0.35 2.96e-11 Survival in pancreatic cancer; CRC trans rs2228479 0.850 rs17226973 chr16:89825248 T/C cg24644049 chr4:85504048 CDS1 0.86 6.93 0.36 2.29e-11 Skin colour saturation; CRC cis rs7617773 0.780 rs77044321 chr3:48349314 C/T cg11946769 chr3:48343235 NME6 0.75 10.0 0.48 1e-20 Coronary artery disease; CRC cis rs6804368 0.649 rs9836912 chr3:30761581 A/G cg06106510 chr3:30762233 NA 0.41 7.47 0.38 7.2e-13 Blood metabolite levels; CRC cis rs926938 0.618 rs360675 chr1:115490918 T/C cg12756093 chr1:115239321 AMPD1 0.57 8.77 0.44 1.01e-16 Autism; CRC cis rs853679 0.517 rs4713135 chr6:28039586 G/A cg25164649 chr6:28176230 NA 0.73 9.16 0.45 5.49e-18 Depression; CRC cis rs6088580 0.634 rs6059896 chr20:33111783 T/C cg24642439 chr20:33292090 TP53INP2 0.41 6.73 0.35 7.44e-11 Glomerular filtration rate (creatinine); CRC cis rs9467773 1.000 rs9986382 chr6:26550619 T/C cg09904177 chr6:26538194 HMGN4 0.86 14.9 0.63 1.01e-38 Intelligence (multi-trait analysis); CRC cis rs9914988 0.887 rs11080072 chr17:27081160 G/T cg12682573 chr17:27188876 MIR451;MIR144 0.62 9.4 0.46 9.58e-19 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs1552244 1.000 rs9875081 chr3:10083935 G/A cg08888203 chr3:10149979 C3orf24 0.7 10.01 0.48 8.99e-21 Alzheimer's disease; CRC cis rs172166 0.516 rs1225715 chr6:28113373 C/T cg12172441 chr6:28176163 NA -0.42 -6.0 -0.31 5.2e-9 Cardiac Troponin-T levels; CRC cis rs4867766 0.585 rs6556141 chr5:173952640 C/T cg20434911 chr5:173954559 NA -0.51 -6.18 -0.32 1.92e-9 Stroke; CRC cis rs5769765 0.646 rs9627789 chr22:50300562 A/G cg08270630 chr22:50330655 NA -0.39 -5.62 -0.3 4.13e-8 Schizophrenia; CRC trans rs3807766 0.581 rs6954104 chr7:77693258 C/T cg01087382 chr6:91297190 MAP3K7 -0.46 -6.34 -0.33 7.56e-10 3-hydroxypropylmercapturic acid levels in smokers; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg08063013 chr11:63742144 COX8A 0.45 6.34 0.33 7.47e-10 Response to antipsychotic treatment; CRC cis rs6714710 0.603 rs35255677 chr2:98567820 G/A cg26665480 chr2:98280029 ACTR1B 0.56 7.72 0.39 1.4e-13 Posterior cortical atrophy and Alzheimer's disease; CRC cis rs763121 0.819 rs5757126 chr22:38923675 T/C cg06544989 chr22:39130855 UNC84B 0.45 6.71 0.35 8.29e-11 Menopause (age at onset); CRC cis rs12476592 0.602 rs2604614 chr2:63894133 T/G cg10828910 chr2:63850056 LOC388955 0.52 6.44 0.33 4.3e-10 Childhood ear infection; CRC cis rs10905065 0.931 rs2497 chr10:5807608 A/G cg11519256 chr10:5708881 ASB13 -0.46 -6.35 -0.33 7.18e-10 Menopause (age at onset); CRC cis rs11677370 0.603 rs10178523 chr2:3854169 G/A cg17052675 chr2:3827356 NA -0.65 -10.71 -0.51 3.57e-23 Type 2 diabetes; CRC cis rs875971 0.545 rs6979636 chr7:65741625 A/G cg18876405 chr7:65276391 NA 0.44 6.59 0.34 1.72e-10 Aortic root size; CRC cis rs4242434 0.889 rs11785755 chr8:22453223 C/A cg03733263 chr8:22462867 KIAA1967 1.02 18.19 0.71 1.14e-51 Exploratory eye movement dysfunction in schizophrenia (cognitive search score); CRC cis rs9896933 0.830 rs113051447 chr17:80791806 A/G cg15664640 chr17:80829946 TBCD -0.55 -6.72 -0.35 8.27e-11 Bone mineral accretion in asthma (oral corticosteroid dose interaction); CRC cis rs1355223 1.000 rs1355223 chr11:34764479 A/G cg11058730 chr11:34937778 PDHX;APIP -0.46 -6.5 -0.34 2.95e-10 Systemic lupus erythematosus and Systemic sclerosis; CRC cis rs7249142 0.506 rs8101388 chr19:19293938 A/C cg26504305 chr19:19281019 LOC729991-MEF2B;MEF2B -0.44 -8.64 -0.43 2.54e-16 IgG glycosylation; CRC trans rs12599106 0.818 rs17723574 chr16:34602945 C/G cg15383120 chr6:291909 DUSP22 -0.49 -6.95 -0.36 2.02e-11 Menopause (age at onset); CRC cis rs875971 0.862 rs778705 chr7:65861115 G/A cg12463550 chr7:65579703 CRCP 0.48 6.52 0.34 2.72e-10 Aortic root size; CRC cis rs6088580 0.634 rs1890000 chr20:32968312 G/T cg08999081 chr20:33150536 PIGU -0.62 -11.69 -0.54 1.27e-26 Glomerular filtration rate (creatinine); CRC cis rs1580019 0.885 rs4460270 chr7:32496450 C/T cg06627557 chr7:32535165 LSM5;AVL9 0.71 11.2 0.53 6.71e-25 Cognitive ability; CRC cis rs10504229 0.683 rs16921810 chr8:58106067 A/G cg05313129 chr8:58192883 C8orf71 -0.43 -5.87 -0.31 1.09e-8 Developmental language disorder (linguistic errors); CRC cis rs4713118 0.619 rs200486 chr6:27779506 C/T cg20933634 chr6:27740509 NA 0.59 7.03 0.36 1.2e-11 Parkinson's disease; CRC cis rs10504229 0.953 rs67677367 chr8:58175264 T/G cg01721255 chr8:58191610 C8orf71 0.49 6.17 0.32 2e-9 Developmental language disorder (linguistic errors); CRC cis rs780096 0.587 rs1049817 chr2:27550967 A/G cg24768116 chr2:27665128 KRTCAP3 -0.31 -7.0 -0.36 1.42e-11 Total body bone mineral density; CRC cis rs7208859 0.623 rs9916725 chr17:29107471 A/C cg01831904 chr17:28903510 LRRC37B2 -0.63 -6.45 -0.33 4.07e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs875971 1.000 rs6945843 chr7:65734783 G/A cg00343986 chr7:65444356 GUSB -0.43 -6.45 -0.33 4.02e-10 Aortic root size; CRC cis rs9649213 0.574 rs34817002 chr7:97887051 G/A cg00277769 chr7:97922759 BAIAP2L1 -0.6 -10.15 -0.49 3.03e-21 Prostate cancer (SNP x SNP interaction); CRC cis rs832540 0.864 rs252908 chr5:56120686 T/C cg24531977 chr5:56204891 C5orf35 -0.45 -6.93 -0.36 2.25e-11 Coronary artery disease; CRC cis rs11122272 0.735 rs910823 chr1:231498766 G/T cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.53 -8.11 -0.41 1.03e-14 Hemoglobin concentration; CRC cis rs4938330 0.608 rs2239012 chr11:117088362 A/G cg01368799 chr11:117014884 PAFAH1B2 -0.47 -6.05 -0.32 3.94e-9 Blood protein levels; CRC cis rs10791323 0.569 rs2156680 chr11:133742292 T/G cg15485101 chr11:133734466 NA 0.43 8.1 0.41 1.06e-14 Childhood ear infection; CRC cis rs9287719 0.870 rs10167676 chr2:10753140 G/A cg00105475 chr2:10696890 NA 0.45 7.17 0.37 4.85e-12 Prostate cancer; CRC cis rs35110281 0.774 rs9978811 chr21:44998683 C/T cg01579765 chr21:45077557 HSF2BP -0.36 -6.86 -0.35 3.37e-11 Mean corpuscular volume; CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg18861140 chr18:3449789 TGIF1 0.45 7.39 0.38 1.24e-12 Obesity-related traits; CRC cis rs6748734 0.817 rs4465762 chr2:241798862 G/A cg16358738 chr2:241808595 AGXT -0.4 -6.25 -0.33 1.24e-9 Urinary metabolites; CRC cis rs12477438 0.520 rs11678456 chr2:99708237 G/A cg14399236 chr2:99771627 LIPT1;TSGA10 0.78 13.68 0.6 5.07e-34 Chronic sinus infection; CRC cis rs9914988 0.943 rs4795467 chr17:27180784 C/T cg20469991 chr17:27169893 C17orf63 -0.52 -5.76 -0.3 1.95e-8 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs6088580 0.634 rs4911151 chr20:32932273 T/C cg24642439 chr20:33292090 TP53INP2 -0.4 -6.68 -0.35 1.03e-10 Glomerular filtration rate (creatinine); CRC cis rs13315871 1.000 rs28668389 chr3:58323942 G/C cg20936604 chr3:58311152 NA -0.76 -7.91 -0.4 4.04e-14 Cholesterol, total; CRC cis rs10540 1.000 rs35811812 chr11:498442 G/A cg03576123 chr11:487126 PTDSS2 -0.9 -9.83 -0.48 3.68e-20 Body mass index; CRC cis rs34375054 0.525 rs7133864 chr12:125606180 C/T cg06287003 chr12:125626642 AACS -0.5 -7.39 -0.38 1.19e-12 Post bronchodilator FEV1/FVC ratio; CRC cis rs1223397 0.702 rs1223400 chr6:13271242 T/C cg20827128 chr6:13274284 PHACTR1 0.55 6.62 0.34 1.46e-10 Blood pressure; CRC cis rs863345 0.564 rs10908667 chr1:158500121 G/A cg12129480 chr1:158549410 OR10X1 -0.3 -6.24 -0.33 1.35e-9 Pneumococcal bacteremia; CRC cis rs10489202 0.608 rs6659593 chr1:168072152 A/T cg24449463 chr1:168025552 DCAF6 -0.5 -6.98 -0.36 1.59e-11 Schizophrenia; CRC cis rs4819052 0.807 rs1075788 chr21:46666564 T/G cg19498844 chr21:46707878 POFUT2;LOC642852 0.72 10.43 0.5 3.53e-22 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs3858526 0.883 rs7481923 chr11:5933342 T/C cg05234568 chr11:5960015 NA -0.53 -7.27 -0.37 2.57e-12 DNA methylation (variation); CRC cis rs9902453 0.967 rs4356528 chr17:28489670 A/G cg26525008 chr17:28256777 EFCAB5;SSH2 0.56 8.42 0.42 1.15e-15 Coffee consumption (cups per day); CRC cis rs28830936 0.966 rs2303518 chr15:42109975 T/G cg17847044 chr15:42102381 MAPKBP1 -0.32 -6.71 -0.35 8.44e-11 Diastolic blood pressure; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg10459029 chr2:242640849 ING5 0.48 6.81 0.35 4.73e-11 Response to antipsychotic treatment; CRC cis rs548181 0.736 rs540723 chr11:125489621 A/G cg03464685 chr11:125439445 EI24 1.08 11.38 0.53 1.56e-25 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs4722166 0.630 rs12700391 chr7:22777327 C/A cg05472934 chr7:22766657 IL6 0.76 12.37 0.56 4.12e-29 Lung cancer; CRC cis rs10791323 0.582 rs2851120 chr11:133708065 A/G cg00579200 chr11:133705235 NA -0.39 -5.68 -0.3 3.03e-8 Childhood ear infection; CRC cis rs875971 0.505 rs1723275 chr7:65504633 G/C cg18912574 chr7:65842487 NCRNA00174 -0.36 -6.09 -0.32 3.15e-9 Aortic root size; CRC cis rs4731207 0.596 rs1481330 chr7:124631363 C/T cg23710748 chr7:124431027 NA -0.43 -6.94 -0.36 2.08e-11 Cutaneous malignant melanoma; CRC cis rs6502050 0.835 rs34287733 chr17:80078236 C/T cg13198984 chr17:80129470 CCDC57 -0.48 -8.5 -0.42 6.61e-16 Life satisfaction; CRC trans rs1814175 0.817 rs11493756 chr11:50017885 T/C cg03929089 chr4:120376271 NA -0.93 -17.98 -0.7 7.84e-51 Height; CRC cis rs5753618 0.539 rs8135344 chr22:31671932 G/T cg22777020 chr22:31556080 RNF185 -0.51 -5.86 -0.31 1.15e-8 Colorectal cancer; CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg05165064 chr20:18037039 OVOL2 -0.53 -6.87 -0.35 3.19e-11 Diisocyanate-induced asthma; CRC cis rs447735 0.587 rs258336 chr16:89720831 A/C cg01097406 chr16:89675127 NA 0.44 8.51 0.42 6.43e-16 Hemoglobin concentration; CRC cis rs1707322 0.752 rs6658700 chr1:46160260 C/T cg06784218 chr1:46089804 CCDC17 0.65 12.15 0.56 2.54e-28 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs9487051 0.698 rs13202939 chr6:109649655 A/G cg01475377 chr6:109611718 NA -0.37 -5.73 -0.3 2.22e-8 Reticulocyte fraction of red cells; CRC cis rs45509595 0.841 rs200501 chr6:27788942 C/T cg23259851 chr6:27775964 HIST1H2AI;HIST1H2BL 0.71 5.93 0.31 7.74e-9 Breast cancer; CRC cis rs7249142 0.562 rs10854009 chr19:19284705 A/C cg26504305 chr19:19281019 LOC729991-MEF2B;MEF2B -0.45 -9.1 -0.45 9.16e-18 IgG glycosylation; CRC trans rs8002861 0.781 rs7322781 chr13:44442238 T/C cg17145862 chr1:211918768 LPGAT1 0.71 14.1 0.61 1.25e-35 Leprosy; CRC cis rs3796352 1.000 rs13069006 chr3:52973305 G/C cg27565382 chr3:53032988 SFMBT1 0.77 6.23 0.32 1.41e-9 Immune reponse to smallpox (secreted IL-2); CRC cis rs1401999 1.000 rs939338 chr3:183704068 A/G cg05044414 chr3:183734942 ABCC5 -0.49 -8.59 -0.43 3.44e-16 Anterior chamber depth; CRC cis rs7680126 0.596 rs10022911 chr4:10140551 A/G cg00071950 chr4:10020882 SLC2A9 -0.47 -6.16 -0.32 2.13e-9 Urate levels in lean individuals;Urate levels in overweight individuals;Urate levels in obese individuals; CRC trans rs9858542 0.953 rs7623659 chr3:49414791 C/T cg21582582 chr3:182698605 DCUN1D1 -0.52 -6.61 -0.34 1.52e-10 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs55883249 0.957 rs17362839 chr2:9754439 T/C cg23886495 chr2:9695866 ADAM17 0.52 5.97 0.31 6.19e-9 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; CRC cis rs10504229 0.906 rs114627636 chr8:58173732 C/T cg11062466 chr8:58055876 NA 0.49 5.67 0.3 3.14e-8 Developmental language disorder (linguistic errors); CRC cis rs28655083 0.550 rs598340 chr16:77102504 A/G cg01753188 chr16:77233325 SYCE1L;MON1B 0.48 6.81 0.35 4.54e-11 Lobe attachment (rater-scored or self-reported); CRC cis rs1552244 0.882 rs3755783 chr3:10029289 A/G cg02579736 chr3:10068473 FANCD2;CIDECP 0.9 10.69 0.51 4.22e-23 Alzheimer's disease; CRC cis rs2228479 0.867 rs62052189 chr16:89975555 G/C cg06558623 chr16:89946397 TCF25 0.89 9.76 0.47 6.25e-20 Skin colour saturation; CRC cis rs7119 0.717 rs12916515 chr15:77818518 G/T cg10437265 chr15:77819839 NA 0.68 12.24 0.56 1.2e-28 Type 2 diabetes; CRC cis rs453301 0.571 rs2929453 chr8:9084341 A/G cg08975724 chr8:8085496 FLJ10661 -0.41 -6.58 -0.34 1.88e-10 Joint mobility (Beighton score); CRC cis rs2204008 0.702 rs3849999 chr12:38483498 G/A cg26384229 chr12:38710491 ALG10B -0.53 -7.56 -0.38 4e-13 Bladder cancer; CRC cis rs7584330 0.704 rs72620820 chr2:238358844 G/A cg14458575 chr2:238380390 NA 0.91 16.37 0.67 1.84e-44 Prostate cancer; CRC cis rs7666738 0.830 rs35822567 chr4:98654138 G/A cg17366294 chr4:99064904 C4orf37 0.35 5.7 0.3 2.66e-8 Colonoscopy-negative controls vs population controls; CRC cis rs875971 0.862 rs11763189 chr7:65983529 G/A cg11764359 chr7:65958608 NA 0.61 9.49 0.46 4.73e-19 Aortic root size; CRC cis rs9322193 0.962 rs4552 chr6:150132319 A/T cg05861140 chr6:150128134 PCMT1 -0.43 -7.01 -0.36 1.33e-11 Lung cancer; CRC cis rs62244186 0.659 rs9873072 chr3:44516496 G/A cg18165381 chr3:44552316 NA -0.39 -5.91 -0.31 8.43e-9 Depressive symptoms; CRC cis rs853679 0.517 rs9368553 chr6:28082265 T/C cg23161317 chr6:28129485 ZNF389 0.54 6.56 0.34 2.12e-10 Depression; CRC cis rs62045849 0.557 rs117708030 chr16:89181220 A/G cg08015503 chr16:89190385 ACSF3 1.04 6.26 0.33 1.19e-9 Red blood cell count; CRC cis rs79839061 0.656 rs3775126 chr4:886345 C/T cg07828340 chr4:882639 GAK 1.13 11.6 0.54 2.58e-26 Intelligence (multi-trait analysis); CRC cis rs782590 0.683 rs782633 chr2:55898203 A/G cg18811423 chr2:55921094 PNPT1 0.85 16.24 0.67 6e-44 Metabolic syndrome; CRC trans rs1814175 0.645 rs28478790 chr11:50054322 C/A cg15704280 chr7:45808275 SEPT13 -0.94 -17.39 -0.69 1.77e-48 Height; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg02190572 chr10:74057806 NA 0.55 7.68 0.39 1.9e-13 Anxiety disorder; CRC trans rs925098 0.577 rs2724470 chr4:17996046 A/G cg06802599 chr6:42981650 MEA1;KLHDC3 -0.42 -6.1 -0.32 2.9e-9 Birth weight;Height; CRC trans rs61931739 0.500 rs7955933 chr12:34473608 A/G cg26384229 chr12:38710491 ALG10B 0.6 8.58 0.43 3.78e-16 Morning vs. evening chronotype; CRC cis rs6842047 1.000 rs10471184 chr4:187122904 C/T cg09526685 chr4:187126073 CYP4V2 -0.49 -6.6 -0.34 1.64e-10 Blood protein levels; CRC cis rs2836974 0.931 rs13047663 chr21:40708818 C/T cg06238570 chr21:40685208 BRWD1 0.7 9.3 0.46 1.97e-18 Cognitive function; CRC cis rs10193935 0.901 rs59984817 chr2:42566909 C/G cg27598129 chr2:42591480 NA -0.72 -8.05 -0.41 1.52e-14 Colonoscopy-negative controls vs population controls; CRC cis rs12476592 0.602 rs262525 chr2:63893158 A/G cg10828910 chr2:63850056 LOC388955 0.51 6.35 0.33 7.16e-10 Childhood ear infection; CRC cis rs4665809 0.549 rs7577896 chr2:26524493 C/T cg04944784 chr2:26401820 FAM59B 0.82 9.5 0.46 4.6e-19 Gut microbiome composition (summer); CRC cis rs950169 0.580 rs1061737 chr15:85183790 G/C cg17507749 chr15:85114479 UBE2QP1 0.65 9.27 0.45 2.58e-18 Schizophrenia; CRC cis rs7412746 0.611 rs4509581 chr1:150774465 A/G cg10589385 chr1:150898437 SETDB1 0.3 6.16 0.32 2.11e-9 Melanoma; CRC cis rs853679 0.569 rs9348798 chr6:28143011 G/A cg03623178 chr6:28175578 NA 0.97 12.38 0.56 3.55e-29 Depression; CRC cis rs1506636 1.000 rs2896332 chr7:123297223 A/T cg03229431 chr7:123269106 ASB15 -0.78 -12.46 -0.57 1.92e-29 Plateletcrit;Platelet count; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg18516317 chr2:54950679 EML6 -0.39 -5.96 -0.31 6.53e-9 Myopia (pathological); CRC cis rs10504229 0.953 rs66676208 chr8:58173866 C/T cg22535103 chr8:58192502 C8orf71 -0.82 -12.27 -0.56 9.63e-29 Developmental language disorder (linguistic errors); CRC cis rs7412746 0.658 rs10305714 chr1:150800655 C/T cg17724175 chr1:150552817 MCL1 -0.48 -7.22 -0.37 3.65e-12 Melanoma; CRC cis rs2346160 1.000 rs7753298 chr6:167664193 G/A cg27333441 chr6:167680455 NA 0.38 6.32 0.33 8.71e-10 Parental extreme longevity (95 years and older); CRC cis rs7666738 0.830 rs1426667 chr4:98949772 T/C cg05340658 chr4:99064831 C4orf37 0.61 9.54 0.47 3.45e-19 Colonoscopy-negative controls vs population controls; CRC cis rs7829975 0.508 rs4841006 chr8:8501474 T/C cg06636001 chr8:8085503 FLJ10661 -0.51 -7.7 -0.39 1.58e-13 Mood instability; CRC cis rs2303759 0.881 rs10412811 chr19:49884495 G/A cg22133161 chr19:49891603 CCDC155 0.51 7.0 0.36 1.42e-11 Multiple sclerosis; CRC cis rs7408868 0.908 rs62113793 chr19:15277336 G/A cg14696996 chr19:15285081 NOTCH3 0.98 9.08 0.45 1.03e-17 Pulse pressure; CRC cis rs2227564 0.729 rs2633303 chr10:75645882 G/T cg16540259 chr10:75572220 NDST2 0.41 5.64 0.3 3.59e-8 Crohn's disease;Inflammatory bowel disease; CRC cis rs611744 0.647 rs676654 chr8:109242303 A/G cg21045802 chr8:109455806 TTC35 0.46 7.01 0.36 1.39e-11 Dupuytren's disease; CRC cis rs4862750 0.881 rs6813866 chr4:187872161 T/G cg11301795 chr4:187892539 NA -0.86 -18.69 -0.72 1.29e-53 Lobe attachment (rater-scored or self-reported); CRC cis rs736801 0.808 rs72797303 chr5:131796163 T/C cg21138405 chr5:131827807 IRF1 -0.36 -6.22 -0.32 1.53e-9 Breast cancer;Mosquito bite size; CRC cis rs11650494 0.908 rs9891264 chr17:47407342 T/A cg08112188 chr17:47440006 ZNF652 0.87 8.73 0.43 1.27e-16 Prostate cancer; CRC cis rs8060686 0.920 rs2292316 chr16:67861134 C/G cg06138825 chr16:67683817 RLTPR 0.52 5.71 0.3 2.51e-8 HDL cholesterol;Metabolic syndrome; CRC cis rs4713118 0.539 rs200988 chr6:27819353 A/C cg15845792 chr6:28175446 NA 0.73 10.46 0.5 2.64e-22 Parkinson's disease; CRC cis rs6499255 0.951 rs12232410 chr16:69736851 G/A cg04110750 chr16:69646130 NFAT5 -0.53 -7.72 -0.39 1.45e-13 IgE levels; CRC cis rs1552244 0.572 rs57268864 chr3:10164233 C/A cg18598329 chr3:10140678 FANCD2;C3orf24 -0.91 -10.81 -0.51 1.62e-23 Alzheimer's disease; CRC cis rs12249377 0.519 rs12259401 chr10:92594121 T/G cg14313238 chr10:92632228 RPP30 0.47 6.48 0.34 3.42e-10 White matter microstructure (global fractional anisotropy); CRC cis rs11958404 0.932 rs76228149 chr5:157434486 G/A cg05962755 chr5:157440814 NA 1.01 12.88 0.58 5.12e-31 IgG glycosylation; CRC cis rs929354 0.772 rs1002389 chr7:156968323 C/G cg16102536 chr7:156981717 UBE3C 0.4 6.69 0.35 9.74e-11 Body mass index; CRC cis rs4481887 1.000 rs7527822 chr1:248467301 A/G cg13385794 chr1:248469461 NA 0.4 6.96 0.36 1.83e-11 Common traits (Other); CRC cis rs6831352 0.918 rs7670060 chr4:100059568 G/T cg12011299 chr4:100065546 ADH4 -0.49 -9.25 -0.45 3.02e-18 Alcohol dependence; CRC cis rs2739330 0.731 rs5751792 chr22:24401542 G/A cg23131131 chr22:24373011 LOC391322 -0.49 -7.43 -0.38 9.33e-13 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs9381040 0.748 rs9357348 chr6:41154232 A/G cg03526776 chr6:41159608 TREML2 0.36 6.53 0.34 2.52e-10 Alzheimer's disease (late onset); CRC cis rs7666738 0.791 rs28858828 chr4:98950442 C/G cg05340658 chr4:99064831 C4orf37 0.61 9.54 0.47 3.45e-19 Colonoscopy-negative controls vs population controls; CRC cis rs1223397 0.938 rs9395602 chr6:13278753 C/T cg20827128 chr6:13274284 PHACTR1 0.55 6.61 0.34 1.56e-10 Blood pressure; CRC cis rs3749237 0.557 rs7631908 chr3:49425707 T/G cg03060546 chr3:49711283 APEH 0.6 10.25 0.49 1.36e-21 Resting heart rate; CRC cis rs4423214 0.840 rs1790341 chr11:71177578 T/C cg13043300 chr11:71146211 DHCR7 -0.44 -5.91 -0.31 8.58e-9 Vitamin D levels; CRC cis rs11122272 0.735 rs2808596 chr1:231530723 A/G cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.56 -8.43 -0.42 1.08e-15 Hemoglobin concentration; CRC cis rs4664293 0.647 rs1966530 chr2:160477408 G/A cg08347373 chr2:160653686 CD302 -0.39 -6.74 -0.35 7.18e-11 Monocyte percentage of white cells; CRC cis rs9322193 0.962 rs7740784 chr6:150154500 C/T cg07701084 chr6:150067640 NUP43 0.57 7.83 0.4 6.72e-14 Lung cancer; CRC cis rs1348850 0.914 rs4893944 chr2:178289357 G/T cg22681709 chr2:178499509 PDE11A -0.37 -6.82 -0.35 4.25e-11 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC trans rs6951245 1.000 rs78308415 chr7:1072634 G/A cg13565492 chr6:43139072 SRF -0.71 -7.2 -0.37 4.18e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs8114671 0.570 rs3761144 chr20:33544075 C/G cg07148914 chr20:33460835 GGT7 0.41 6.57 0.34 1.97e-10 Height; CRC cis rs17345786 1.000 rs3804778 chr3:101294572 C/T cg12386194 chr3:101231763 SENP7 0.51 6.35 0.33 7.21e-10 Colonoscopy-negative controls vs population controls; CRC cis rs1873147 0.569 rs11071710 chr15:63309193 A/G cg12160578 chr15:63334699 TPM1 0.61 7.22 0.37 3.62e-12 Orofacial clefts; CRC cis rs9457247 0.510 rs6456151 chr6:167471851 A/C cg07741184 chr6:167504864 NA 0.39 6.85 0.35 3.66e-11 Crohn's disease; CRC trans rs7944735 0.517 rs74763661 chr11:48233772 T/C cg15704280 chr7:45808275 SEPT13 0.69 6.8 0.35 5.06e-11 Intraocular pressure; CRC cis rs1448094 0.512 rs57278040 chr12:86237886 A/G cg02569458 chr12:86230093 RASSF9 0.43 7.27 0.37 2.56e-12 Major depressive disorder; CRC cis rs3741151 1.000 rs61037777 chr11:73046663 A/G cg17517138 chr11:73019481 ARHGEF17 0.67 6.99 0.36 1.56e-11 GIP levels in response to oral glucose tolerance test (120 minutes); CRC cis rs1577917 1.000 rs884841 chr6:86680300 A/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.51 -6.83 -0.35 4.23e-11 Response to antipsychotic treatment; CRC cis rs6570726 0.935 rs409725 chr6:145840340 G/A cg23711669 chr6:146136114 FBXO30 0.68 12.16 0.56 2.33e-28 Lobe attachment (rater-scored or self-reported); CRC trans rs7937682 0.889 rs490199 chr11:111487890 A/G cg18187862 chr3:45730750 SACM1L 0.45 6.47 0.34 3.61e-10 Primary sclerosing cholangitis; CRC cis rs2289583 0.544 rs6495132 chr15:75255322 C/T cg14664628 chr15:75095509 CSK 0.42 5.68 0.3 2.93e-8 Systemic lupus erythematosus; CRC cis rs1707322 0.717 rs28752166 chr1:46213309 G/A cg06784218 chr1:46089804 CCDC17 0.65 12.05 0.55 5.8e-28 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC trans rs11039798 0.764 rs11040030 chr11:48800985 C/T cg03929089 chr4:120376271 NA 0.63 6.01 0.31 4.92e-9 Axial length; CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg02445447 chr2:106015594 FHL2 0.43 6.96 0.36 1.87e-11 Obesity-related traits; CRC cis rs11758351 1.000 rs77957229 chr6:26185226 A/G cg10723962 chr6:26240782 HIST1H4F -0.4 -6.03 -0.32 4.38e-9 Gout;Renal underexcretion gout; CRC cis rs11690935 0.851 rs10201430 chr2:172813241 T/C cg13550731 chr2:172543902 DYNC1I2 -0.97 -15.37 -0.65 1.46e-40 Schizophrenia; CRC cis rs11155671 0.530 rs7742993 chr6:150205095 G/A cg07701084 chr6:150067640 NUP43 0.51 7.41 0.38 1.09e-12 Testicular germ cell tumor; CRC trans rs1005277 0.579 rs1740742 chr10:38518860 C/T cg11292332 chr7:45801988 SEPT13 -0.39 -7.05 -0.36 1.05e-11 Extrinsic epigenetic age acceleration; CRC trans rs6076960 0.623 rs6038407 chr20:6267326 A/G cg24759859 chr6:86352639 SYNCRIP 0.48 6.48 0.34 3.29e-10 Smooth-surface caries; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg25744181 chr1:231664219 TSNAX-DISC1;TSNAX 0.44 6.1 0.32 3.06e-9 Response to antipsychotic treatment; CRC cis rs9322193 0.962 rs7745915 chr6:150155247 C/T cg05861140 chr6:150128134 PCMT1 -0.44 -7.12 -0.37 6.69e-12 Lung cancer; CRC cis rs1799949 1.000 rs33994002 chr17:41328818 T/A cg25072359 chr17:41440525 NA 0.46 6.91 0.36 2.52e-11 Menopause (age at onset); CRC cis rs1707322 0.963 rs6690652 chr1:46376692 G/T cg06784218 chr1:46089804 CCDC17 0.52 9.12 0.45 7.88e-18 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs12950390 0.853 rs11079792 chr17:45863311 T/C cg24803719 chr17:45855879 NA -0.31 -6.93 -0.36 2.28e-11 IgG glycosylation; CRC cis rs4843747 0.708 rs11866437 chr16:88072279 A/G cg17633681 chr16:88106987 BANP -0.78 -13.89 -0.61 7.74e-35 Menopause (age at onset); CRC cis rs9916302 0.904 rs801419 chr17:37466327 A/G cg03013999 chr17:37608204 MED1 -0.46 -7.02 -0.36 1.29e-11 Glomerular filtration rate (creatinine); CRC cis rs6088580 0.634 rs4911423 chr20:32999386 T/A cg08999081 chr20:33150536 PIGU -0.61 -11.52 -0.54 4.84e-26 Glomerular filtration rate (creatinine); CRC cis rs1656402 0.906 rs7607107 chr2:233452344 T/G cg03852847 chr2:233439513 NA -0.41 -6.82 -0.35 4.45e-11 Non-small cell lung cancer (survival); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg02545393 chr11:70244902 CTTN 0.39 6.31 0.33 9e-10 Liver disease severity in Alagille syndrome; CRC cis rs2228479 0.717 rs9282682 chr16:89805794 A/G cg19635926 chr16:89946313 TCF25 0.65 6.7 0.35 9.28e-11 Skin colour saturation; CRC cis rs62229266 0.804 rs2835241 chr21:37411380 G/T cg08632701 chr21:37451849 NA 0.44 6.87 0.35 3.13e-11 Mitral valve prolapse; CRC cis rs929354 0.772 rs1182441 chr7:157026650 A/G cg05182265 chr7:156933206 UBE3C 0.76 14.55 0.63 2.33e-37 Body mass index; CRC cis rs4820539 0.966 rs5759600 chr22:23483769 C/A cg14186256 chr22:23484241 RTDR1 0.9 17.66 0.7 1.46e-49 Bone mineral density; CRC cis rs10769945 0.679 rs7102920 chr11:1917872 C/T cg23202291 chr11:1979235 NA 0.41 6.02 0.32 4.53e-9 DNA methylation (variation); CRC cis rs6502050 0.835 rs7503225 chr17:80099639 C/A cg19223190 chr17:80058835 NA 0.4 6.36 0.33 6.88e-10 Life satisfaction; CRC cis rs4689388 0.853 rs1079216 chr4:6282473 T/C cg00701064 chr4:6280414 WFS1 0.77 13.12 0.59 6.45e-32 Type 2 diabetes and other traits;Type 2 diabetes; CRC cis rs4722166 0.695 rs7787893 chr7:22774437 A/G cg26061582 chr7:22766209 IL6 0.54 8.86 0.44 5.23e-17 Lung cancer; CRC cis rs6604026 0.656 rs2774945 chr1:93346239 T/C cg17283838 chr1:93427260 FAM69A -0.44 -5.69 -0.3 2.76e-8 Multiple sclerosis; CRC cis rs10924970 0.687 rs28593631 chr1:235354572 A/T cg26050004 chr1:235667680 B3GALNT2 0.39 5.74 0.3 2.13e-8 Asthma; CRC cis rs9611565 0.659 rs1810460 chr22:41927700 C/T cg06634786 chr22:41940651 POLR3H -0.62 -7.25 -0.37 2.93e-12 Vitiligo; CRC cis rs2204008 0.522 rs117743143 chr12:38030824 C/T cg26384229 chr12:38710491 ALG10B 0.64 9.83 0.48 3.63e-20 Bladder cancer; CRC cis rs7312933 1.000 rs11181328 chr12:42504679 T/G cg11827402 chr12:42719852 PPHLN1;ZCRB1 0.59 7.46 0.38 7.83e-13 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg07481194 chr14:23398747 PRMT5 0.44 5.99 0.31 5.6e-9 Response to antipsychotic treatment; CRC trans rs6545883 0.965 rs6545872 chr2:61724568 G/A cg11704114 chr12:21509398 SLCO1A2 -0.32 -6.02 -0.31 4.62e-9 Tuberculosis; CRC cis rs6693567 0.565 rs7513182 chr1:150442612 A/G cg04165759 chr1:150448943 RPRD2 -0.34 -5.66 -0.3 3.38e-8 Migraine; CRC cis rs597539 0.652 rs667989 chr11:68685776 T/A cg06112835 chr11:68658793 MRPL21 0.43 6.73 0.35 7.33e-11 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC trans rs12599106 0.648 rs12447240 chr16:34928236 C/T cg07332563 chr6:291687 DUSP22 0.59 8.43 0.42 1.11e-15 Menopause (age at onset); CRC trans rs5756813 0.688 rs56114444 chr22:38123364 C/T cg19894588 chr14:64061835 NA -0.59 -7.71 -0.39 1.47e-13 Optic cup area;Vertical cup-disc ratio; CRC cis rs7769051 0.522 rs6934155 chr6:133124021 C/T cg07930552 chr6:133119739 C6orf192 0.92 7.33 0.37 1.84e-12 Type 2 diabetes nephropathy; CRC cis rs6424115 0.830 rs3123554 chr1:24196401 C/T cg09473613 chr1:24152604 HMGCL -0.34 -5.72 -0.3 2.41e-8 Immature fraction of reticulocytes; CRC cis rs172166 0.694 rs9295760 chr6:28147385 G/A cg06470822 chr6:28175283 NA 0.83 12.2 0.56 1.72e-28 Cardiac Troponin-T levels; CRC cis rs6964587 0.933 rs28671255 chr7:91770705 A/G cg17063962 chr7:91808500 NA 0.84 14.96 0.64 5.65e-39 Breast cancer; CRC cis rs35306767 0.903 rs12761424 chr10:967295 C/T cg20503657 chr10:835505 NA 0.79 10.11 0.49 4.26e-21 Eosinophil percentage of granulocytes; CRC cis rs12477438 0.765 rs17708262 chr2:99696313 T/A cg14399236 chr2:99771627 LIPT1;TSGA10 -0.6 -8.18 -0.41 6.47e-15 Chronic sinus infection; CRC cis rs12701220 0.744 rs2030958 chr7:1076010 G/T cg02733842 chr7:1102375 C7orf50 -0.79 -9.15 -0.45 6.2e-18 Bronchopulmonary dysplasia; CRC cis rs28386778 0.897 rs2597634 chr17:61878144 G/A cg06601766 chr17:61851465 DDX42;CCDC47 0.45 6.14 0.32 2.4e-9 Prudent dietary pattern; CRC cis rs10193935 0.901 rs871045 chr2:42609431 G/C cg27598129 chr2:42591480 NA -0.66 -7.51 -0.38 5.64e-13 Colonoscopy-negative controls vs population controls; CRC trans rs1005277 0.579 rs11011461 chr10:38431427 G/A cg27523141 chr10:43048294 ZNF37B 0.49 7.18 0.37 4.65e-12 Extrinsic epigenetic age acceleration; CRC cis rs1448094 0.512 rs61930862 chr12:86246567 A/G cg00310523 chr12:86230176 RASSF9 0.35 5.93 0.31 7.63e-9 Major depressive disorder; CRC cis rs208520 0.690 rs207102 chr6:66795671 G/A cg07460842 chr6:66804631 NA -1.09 -15.38 -0.65 1.37e-40 Exhaled nitric oxide output; CRC cis rs561341 0.941 rs2428341 chr17:30317295 C/T cg12193833 chr17:30244370 NA -0.58 -8.01 -0.4 1.96e-14 Hip circumference adjusted for BMI; CRC cis rs7772486 0.875 rs6930975 chr6:146387111 C/T cg13319975 chr6:146136371 FBXO30 -0.38 -5.76 -0.3 1.97e-8 Lobe attachment (rater-scored or self-reported); CRC cis rs9635726 0.638 rs2952155 chr17:37861718 T/C cg20243544 chr17:37824526 PNMT 0.6 8.49 0.42 7.4e-16 Primary biliary cholangitis; CRC trans rs1814175 0.616 rs1722001 chr11:49894427 A/G cg15704280 chr7:45808275 SEPT13 -0.94 -16.84 -0.68 2.56e-46 Height; CRC cis rs4237845 0.780 rs3751331 chr12:58290278 G/A cg02175503 chr12:58329896 NA 0.53 6.78 0.35 5.54e-11 Intelligence (multi-trait analysis); CRC cis rs34311866 0.752 rs11725653 chr4:963397 C/T cg14530993 chr4:882597 GAK 0.75 6.91 0.36 2.59e-11 Parkinson's disease; CRC cis rs6754311 0.628 rs309811 chr2:136625602 A/G cg15123519 chr2:136567270 LCT 0.34 6.57 0.34 1.95e-10 Mosquito bite size; CRC cis rs6860806 0.661 rs2171247 chr5:131580234 G/T cg04518342 chr5:131593106 PDLIM4 0.45 8.18 0.41 6.2e-15 Breast cancer; CRC cis rs875971 0.895 rs1833495 chr7:65921595 T/C cg12463550 chr7:65579703 CRCP 0.48 6.78 0.35 5.54e-11 Aortic root size; CRC cis rs11212617 0.934 rs694376 chr11:108119048 C/A cg14761454 chr11:108092087 ATM;NPAT 0.39 5.73 0.3 2.23e-8 Response to metformin in type 2 diabetes (glycemic); CRC cis rs7666738 1.000 rs7666738 chr4:98968077 C/T cg05340658 chr4:99064831 C4orf37 0.51 7.25 0.37 2.94e-12 Colonoscopy-negative controls vs population controls; CRC cis rs10504229 0.775 rs55764517 chr8:58158238 G/A cg22535103 chr8:58192502 C8orf71 -0.7 -8.43 -0.42 1.07e-15 Developmental language disorder (linguistic errors); CRC cis rs60843830 0.928 rs55742348 chr2:217563 T/A cg00108164 chr2:264199 ACP1;SH3YL1 0.63 9.8 0.48 4.59e-20 Spherical equivalent (joint analysis main effects and education interaction); CRC cis rs7635838 0.892 rs34830847 chr3:11437798 A/C cg00170343 chr3:11313890 ATG7 0.41 6.35 0.33 7.03e-10 HDL cholesterol; CRC cis rs7208859 0.673 rs61223749 chr17:29163747 G/A cg14008862 chr17:28927542 LRRC37B2 0.55 5.8 0.3 1.56e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs7904368 0.806 rs7099178 chr10:16862578 C/G cg14835575 chr10:16859367 RSU1 0.44 5.91 0.31 8.73e-9 Ratio of the peak velocity of the mitral E-Wave divided by the peak velocity of the mitral A-wave.; CRC cis rs873946 0.586 rs3793685 chr10:134569316 G/A cg06453172 chr10:134556979 INPP5A -0.69 -8.23 -0.41 4.32e-15 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CRC cis rs4629710 0.617 rs28360555 chr6:131538952 C/A cg12606694 chr6:131520996 AKAP7 0.56 8.41 0.42 1.25e-15 Multiple myeloma (IgH translocation); CRC trans rs61931739 0.517 rs7958856 chr12:34294737 T/C cg26384229 chr12:38710491 ALG10B 0.53 6.75 0.35 6.88e-11 Morning vs. evening chronotype; CRC cis rs10256972 0.577 rs6962809 chr7:1208889 A/G cg22907277 chr7:1156413 C7orf50 0.65 9.81 0.48 4.2e-20 Longevity;Endometriosis; CRC cis rs6502050 0.635 rs11867440 chr17:80147185 A/T cg22110888 chr17:80059540 CCDC57 0.4 6.24 0.33 1.33e-9 Life satisfaction; CRC cis rs10504229 0.639 rs35527749 chr8:58128077 G/T cg11062466 chr8:58055876 NA 0.57 7.05 0.36 1.04e-11 Developmental language disorder (linguistic errors); CRC cis rs9818758 0.607 rs11713297 chr3:49213030 A/G cg00383909 chr3:49044727 WDR6 0.84 8.72 0.43 1.36e-16 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; CRC cis rs9463078 0.653 rs1411148 chr6:45043618 A/G cg25276700 chr6:44698697 NA -0.24 -5.82 -0.31 1.4e-8 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; CRC cis rs2836974 0.966 rs7283420 chr21:40666865 T/C cg06238570 chr21:40685208 BRWD1 0.76 10.33 0.49 7.54e-22 Cognitive function; CRC cis rs72781680 0.898 rs72780191 chr2:24007122 T/C cg08917208 chr2:24149416 ATAD2B 0.98 9.25 0.45 2.88e-18 Lymphocyte counts; CRC cis rs6743226 0.934 rs7604465 chr2:242249828 C/T cg10021735 chr2:242295487 FARP2 0.47 6.9 0.36 2.73e-11 Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI in non-smokers; CRC cis rs8177253 1.000 rs8177252 chr3:133480174 C/A cg11941060 chr3:133502564 NA -0.6 -10.54 -0.5 1.46e-22 Iron status biomarkers; CRC cis rs6693567 0.545 rs4970922 chr1:150458094 C/A cg15654264 chr1:150340011 RPRD2 0.4 5.92 0.31 7.99e-9 Migraine; CRC cis rs7605827 0.930 rs11676115 chr2:15602962 G/A cg19274914 chr2:15703543 NA 0.39 5.92 0.31 8.2e-9 Educational attainment (years of education); CRC trans rs7647973 0.710 rs1532204 chr3:49609477 C/G cg21659725 chr3:3221576 CRBN -0.69 -7.14 -0.37 6.11e-12 Menarche (age at onset); CRC cis rs17713451 0.593 rs6955903 chr7:151269152 C/G cg18404559 chr7:151322523 PRKAG2 -0.57 -6.41 -0.33 5.12e-10 Interleukin-4 levels; CRC cis rs1887596 0.705 rs533287 chr13:27197419 G/A cg01312412 chr13:27282625 NA 0.45 6.0 0.31 5.11e-9 Facial morphology (factor 3, length of philtrum); CRC cis rs800160 0.777 rs2521294 chr11:2348778 C/T cg09785033 chr11:2336066 TSPAN32 -0.55 -6.48 -0.34 3.39e-10 Bacteremia; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg16091319 chr1:193028569 TROVE2;UCHL5 0.41 5.98 0.31 5.73e-9 Intelligence (multi-trait analysis); CRC cis rs7635838 0.722 rs2594982 chr3:11379958 C/T cg00170343 chr3:11313890 ATG7 0.46 7.08 0.36 8.84e-12 HDL cholesterol; CRC cis rs7202877 0.706 rs4887813 chr16:75312494 A/G cg03315344 chr16:75512273 CHST6 0.54 6.14 0.32 2.31e-9 Type 2 diabetes;Type 1 diabetes; CRC cis rs2274273 0.624 rs7155954 chr14:55750943 G/A cg10130446 chr14:55658398 DLGAP5 -0.42 -6.0 -0.31 5.22e-9 Protein biomarker; CRC cis rs1387259 0.570 rs12368659 chr12:48562299 C/A cg21466736 chr12:48725269 NA -0.47 -7.21 -0.37 3.97e-12 Obstructive sleep apnea trait (apnea hypopnea index); CRC cis rs17270561 0.609 rs4712957 chr6:25719814 C/T cg17691542 chr6:26056736 HIST1H1C 0.64 8.21 0.41 5.1e-15 Iron status biomarkers; CRC cis rs10242455 0.557 rs45492501 chr7:99047030 T/A cg18809830 chr7:99032528 PTCD1 -1.03 -7.68 -0.39 1.85e-13 Blood metabolite levels; CRC cis rs4713118 0.955 rs9380012 chr6:27684654 A/G cg03623178 chr6:28175578 NA 0.63 8.4 0.42 1.36e-15 Parkinson's disease; CRC cis rs561341 1.000 rs4795667 chr17:30244443 T/C cg00745463 chr17:30367425 LRRC37B -0.8 -8.84 -0.44 5.76e-17 Hip circumference adjusted for BMI; CRC cis rs2033711 0.870 rs4801270 chr19:58932762 C/A cg13877915 chr19:58951672 ZNF132 0.51 8.45 0.42 9.22e-16 Uric acid clearance; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg14325169 chr10:60145452 TFAM 0.44 6.44 0.33 4.13e-10 Intelligence (multi-trait analysis); CRC cis rs2549003 1.000 rs7735073 chr5:131815357 G/A cg02551604 chr5:131831745 NA -0.54 -8.38 -0.42 1.58e-15 Asthma (sex interaction); CRC cis rs780096 0.526 rs1406295 chr2:27689700 A/G cg21248554 chr2:27665150 KRTCAP3 -0.33 -7.82 -0.4 7.44e-14 Total body bone mineral density; CRC trans rs2228479 0.867 rs35542367 chr16:89965825 G/C cg21302420 chr1:112162376 RAP1A 0.71 6.63 0.34 1.4e-10 Skin colour saturation; CRC cis rs501120 1.000 rs534079 chr10:44752558 G/T cg09554077 chr10:44749378 NA 0.89 13.32 0.59 1.14e-32 Coronary artery disease;Coronary heart disease; CRC cis rs11574514 0.661 rs8058310 chr16:67893839 G/A cg26727032 chr16:67993705 SLC12A4 -0.61 -5.91 -0.31 8.58e-9 Crohn's disease; CRC cis rs904251 0.737 rs914347 chr6:37484970 A/C cg01843034 chr6:37503916 NA -0.46 -8.71 -0.43 1.54e-16 Cognitive performance; CRC cis rs703842 0.642 rs10876994 chr12:58064737 A/C cg18357645 chr12:58087776 OS9 -0.49 -5.75 -0.3 1.99e-8 Multiple sclerosis; CRC cis rs877282 1.000 rs71491304 chr10:772982 C/T cg17470449 chr10:769945 NA 0.6 8.43 0.42 1.1e-15 Uric acid levels; CRC cis rs875971 0.862 rs4368860 chr7:65608482 C/G cg00343986 chr7:65444356 GUSB -0.42 -5.91 -0.31 8.53e-9 Aortic root size; CRC cis rs6546550 0.935 rs60207187 chr2:70093910 G/A cg02498382 chr2:70120550 SNRNP27 -0.4 -6.44 -0.33 4.15e-10 Prevalent atrial fibrillation; CRC cis rs6951245 1.000 rs78861357 chr7:1095418 C/T cg04025307 chr7:1156635 C7orf50 0.63 6.74 0.35 7.02e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs8180040 0.932 rs12490058 chr3:47529063 T/C cg27129171 chr3:47204927 SETD2 0.52 8.08 0.41 1.27e-14 Colorectal cancer; CRC cis rs17092148 0.790 rs6087602 chr20:33170689 G/A cg08999081 chr20:33150536 PIGU 0.5 6.38 0.33 5.94e-10 Neuroticism; CRC cis rs4819052 0.851 rs8126930 chr21:46671715 A/G cg11663144 chr21:46675770 NA -0.69 -11.46 -0.53 8.49e-26 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs4664293 0.867 rs2303550 chr2:160637621 G/A cg08347373 chr2:160653686 CD302 -0.47 -7.47 -0.38 7.5e-13 Monocyte percentage of white cells; CRC trans rs2018683 0.707 rs4722878 chr7:28973031 C/T cg19402173 chr7:128379420 CALU -0.42 -6.12 -0.32 2.61e-9 Response to irinotecan and platinum-based chemotherapy in non-small-cell lung cancer; CRC cis rs1506636 0.512 rs1035015 chr7:123309842 G/C cg03229431 chr7:123269106 ASB15 0.72 8.8 0.44 8.06e-17 Plateletcrit;Platelet count; CRC trans rs7829975 0.626 rs907183 chr8:8729761 C/G cg16141378 chr3:129829833 LOC729375 0.45 6.77 0.35 5.83e-11 Mood instability; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg12232852 chr3:69129018 UBA3 0.47 6.14 0.32 2.42e-9 Thyroid stimulating hormone; CRC cis rs12594515 1.000 rs8038058 chr15:45990272 C/T cg06207120 chr15:45996521 NA 0.32 7.76 0.39 1.05e-13 Waist circumference;Weight; CRC cis rs10028773 0.632 rs34481394 chr4:120248374 C/T cg09307838 chr4:120376055 NA 0.64 9.48 0.46 5.15e-19 Educational attainment; CRC cis rs6951245 1.000 rs79327308 chr7:1108141 A/C cg04025307 chr7:1156635 C7orf50 0.66 7.09 0.36 8.05e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs10504229 0.683 rs7827881 chr8:58132137 C/T cg02290350 chr8:58132656 NA -0.57 -8.01 -0.4 1.97e-14 Developmental language disorder (linguistic errors); CRC cis rs6594535 0.922 rs3797737 chr5:111090124 C/G cg06838283 chr5:111090142 C5orf13 0.55 8.34 0.42 2.08e-15 Chickenpox; CRC cis rs9517320 1.000 rs7338549 chr13:99142745 C/T cg07423050 chr13:99094983 FARP1 0.38 6.01 0.31 4.89e-9 Longevity; CRC cis rs748404 0.560 rs1869258 chr15:43803621 A/C cg02155558 chr15:43621948 ADAL;LCMT2 0.52 7.49 0.38 6.38e-13 Lung cancer; CRC cis rs9469913 0.668 rs76967117 chr6:34603691 G/A cg17674042 chr6:34482479 PACSIN1 -0.74 -7.11 -0.37 7.05e-12 Body mass index (joint analysis main effects and physical activity interaction);Body mass index;Body mass index in physically active individuals; CRC cis rs7666738 0.830 rs35433756 chr4:99070555 C/T cg17366294 chr4:99064904 C4orf37 0.43 7.29 0.37 2.29e-12 Colonoscopy-negative controls vs population controls; CRC cis rs7666738 0.791 rs62318907 chr4:99037120 C/T cg05340658 chr4:99064831 C4orf37 0.6 9.4 0.46 9.75e-19 Colonoscopy-negative controls vs population controls; CRC cis rs7246657 0.943 rs12981532 chr19:37889280 G/A cg23950597 chr19:37808831 NA -0.54 -6.5 -0.34 2.93e-10 Coronary artery calcification; CRC cis rs7178572 0.568 rs4886866 chr15:77696166 A/T cg22256960 chr15:77711686 NA -0.68 -9.85 -0.48 3.2e-20 Type 2 diabetes; CRC cis rs9611565 0.659 rs9607815 chr22:41950671 A/T cg06481639 chr22:41940642 POLR3H -0.52 -6.08 -0.32 3.42e-9 Vitiligo; CRC cis rs4243830 0.510 rs7518459 chr1:6596678 C/G cg05709478 chr1:6581295 PLEKHG5 -0.58 -6.93 -0.36 2.25e-11 Body mass index; CRC cis rs12451471 0.637 rs12950757 chr17:78096800 T/G cg24585782 chr17:78113791 EIF4A3 -0.52 -7.09 -0.36 8.41e-12 Plateletcrit;Mean corpuscular hemoglobin concentration; CRC cis rs2315504 0.568 rs8078796 chr17:38963647 G/A cg06456531 chr17:38929184 KRT26 -0.32 -5.8 -0.3 1.6e-8 Height; CRC trans rs11098499 0.954 rs6820115 chr4:120398182 T/C cg25214090 chr10:38739885 LOC399744 0.63 10.33 0.49 7.61e-22 Corneal astigmatism; CRC cis rs9486719 1.000 rs28623445 chr6:96899116 G/T cg06623918 chr6:96969491 KIAA0776 -0.81 -9.47 -0.46 5.55e-19 Migraine;Coronary artery disease; CRC cis rs6860806 0.507 rs274570 chr5:131713226 C/T cg11843238 chr5:131593191 PDLIM4 -0.43 -7.31 -0.37 2.07e-12 Breast cancer; CRC cis rs3733585 0.638 rs7377625 chr4:9953099 T/C cg11266682 chr4:10021025 SLC2A9 -0.47 -9.58 -0.47 2.41e-19 Cleft plate (environmental tobacco smoke interaction); CRC cis rs17539620 0.507 rs6927301 chr6:154872080 G/T cg20019720 chr6:154832845 CNKSR3 -0.34 -7.53 -0.38 5.09e-13 Lipoprotein (a) levels; CRC cis rs4688759 0.719 rs73079018 chr3:49875327 T/C cg01304814 chr3:48885189 PRKAR2A 0.81 6.26 0.33 1.23e-9 Blood protein levels; CRC cis rs11249608 0.636 rs13359549 chr5:178449178 T/A cg01312482 chr5:178451176 ZNF879 -0.36 -6.07 -0.32 3.55e-9 Pubertal anthropometrics; CRC cis rs17666538 0.585 rs1703927 chr8:613620 A/G cg02524346 chr8:600233 NA -0.76 -7.49 -0.38 6.54e-13 IgG glycosylation; CRC cis rs754466 0.724 rs11002318 chr10:79633807 G/A cg17075019 chr10:79541650 NA -0.88 -15.23 -0.64 4.95e-40 Liver enzyme levels (gamma-glutamyl transferase); CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg02047359 chr10:75174015 ANXA7 -0.51 -6.3 -0.33 9.78e-10 Diisocyanate-induced asthma; CRC cis rs6694672 1.000 rs9427940 chr1:196943353 G/T cg13682187 chr1:196946512 CFHR5 -0.46 -6.84 -0.35 3.79e-11 Asthma; CRC cis rs7215564 0.643 rs59992540 chr17:78658265 G/A cg09596252 chr17:78655493 RPTOR 0.53 5.66 0.3 3.26e-8 Myopia (pathological); CRC cis rs155076 1.000 rs261432 chr13:21865915 G/C cg21970626 chr13:21893289 NA 0.42 5.82 0.31 1.36e-8 White matter hyperintensity burden; CRC cis rs2732480 0.577 rs2732486 chr12:48737834 G/A cg21466736 chr12:48725269 NA -0.59 -8.67 -0.43 2.02e-16 Hemoglobin concentration;Red blood cell count;Hematocrit; CRC cis rs40363 0.645 rs1690446 chr16:3519009 T/C cg00484396 chr16:3507460 NAT15 0.55 7.87 0.4 5.09e-14 Tuberculosis; CRC cis rs7394190 0.810 rs7394178 chr10:75421580 G/A cg07699608 chr10:75541558 CHCHD1 0.58 6.19 0.32 1.77e-9 Incident atrial fibrillation; CRC trans rs747334 0.846 rs4423105 chr10:92724446 C/G cg19856520 chr1:39696676 MACF1 -0.32 -5.97 -0.31 6.05e-9 Fibroblast growth factor basic levels; CRC cis rs3204270 0.500 rs62077175 chr17:79649568 G/T cg18367735 chr17:79674897 NA 0.49 5.7 0.3 2.6e-8 Dental caries; CRC cis rs3136516 0.504 rs11038910 chr11:46543524 C/T cg16389345 chr11:46697382 NA 0.35 5.65 0.3 3.54e-8 Venous thromboembolism; CRC cis rs875971 0.638 rs10278816 chr7:66036987 T/C cg11764359 chr7:65958608 NA -0.55 -8.63 -0.43 2.66e-16 Aortic root size; CRC cis rs8014204 0.762 rs973879 chr14:75297727 T/C cg03030879 chr14:75389066 RPS6KL1 -0.41 -6.55 -0.34 2.16e-10 Caffeine consumption; CRC cis rs3617 0.573 rs9810807 chr3:52924227 C/T cg18099408 chr3:52552593 STAB1 0.34 5.82 0.31 1.38e-8 Red blood cell count;Autism spectrum disorder or schizophrenia; CRC cis rs4664293 0.647 rs6432539 chr2:160448720 T/C cg08347373 chr2:160653686 CD302 -0.38 -6.48 -0.34 3.42e-10 Monocyte percentage of white cells; CRC cis rs1862618 0.671 rs832531 chr5:56228401 A/G cg18230493 chr5:56204884 C5orf35 -0.59 -8.66 -0.43 2.2e-16 Initial pursuit acceleration; CRC cis rs847577 0.646 rs10270222 chr7:97781799 C/T cg24562669 chr7:97807699 LMTK2 -0.61 -11.46 -0.53 8.22e-26 Breast cancer; CRC cis rs2072510 0.932 rs10859999 chr12:96391334 A/G cg22491680 chr12:96389547 HAL 0.39 5.98 0.31 5.66e-9 Metabolite levels (small molecules and protein measures); CRC cis rs2522056 1.000 rs10900807 chr5:131757480 G/C cg20512303 chr5:131592959 PDLIM4 -0.36 -5.63 -0.3 3.9e-8 Lymphocyte counts;Fibrinogen; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg12892311 chr8:8860454 ERI1 0.4 6.04 0.32 4.2e-9 Intelligence (multi-trait analysis); CRC trans rs561341 0.882 rs504887 chr17:30322881 T/A cg27661571 chr11:113659931 NA -0.81 -9.84 -0.48 3.51e-20 Hip circumference adjusted for BMI; CRC cis rs10982256 0.774 rs12551529 chr9:117256896 A/G cg13636371 chr9:117264095 DFNB31 -0.34 -6.55 -0.34 2.17e-10 Bipolar disorder; CRC trans rs2727020 0.563 rs10769582 chr11:49474040 T/C cg15704280 chr7:45808275 SEPT13 -0.92 -17.56 -0.7 3.78e-49 Coronary artery disease; CRC cis rs7781266 0.790 rs73148998 chr7:133181812 C/T cg03336402 chr7:133662267 EXOC4 0.47 5.62 0.3 4.03e-8 Educational attainment (college completion); CRC cis rs2257205 0.667 rs16943186 chr17:56801848 C/T cg25885038 chr17:56607967 SEPT4 -0.52 -5.71 -0.3 2.5e-8 Pancreatic cancer; CRC cis rs9372498 0.536 rs1319988 chr6:118782379 G/A cg24463073 chr6:118973353 C6orf204 0.52 6.84 0.35 3.84e-11 Diastolic blood pressure; CRC cis rs9910055 0.529 rs183462 chr17:42183376 G/C cg10896456 chr17:42255109 ASB16;C17orf65 -0.37 -5.67 -0.3 3.18e-8 Total body bone mineral density; CRC cis rs1707322 0.752 rs28507722 chr1:46206540 A/G cg03146154 chr1:46216737 IPP 0.68 9.85 0.48 3.13e-20 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs798554 1.000 rs798548 chr7:2760935 A/G cg14895029 chr7:2775587 GNA12 -0.38 -5.76 -0.3 1.89e-8 Height; CRC cis rs11155671 0.530 rs2342767 chr6:150209717 C/G cg07701084 chr6:150067640 NUP43 0.49 7.2 0.37 4.04e-12 Testicular germ cell tumor; CRC cis rs2019137 0.560 rs10175462 chr2:113988492 G/A cg07594247 chr2:113993304 PAX8;LOC440839;LOC654433 0.49 7.62 0.39 2.82e-13 Lymphocyte counts; CRC trans rs1376359 0.673 rs35759666 chr1:103155715 T/A cg16220183 chr17:56609687 SEPT4 -0.45 -6.26 -0.33 1.17e-9 QRS duration in Tripanosoma cruzi seropositivity; CRC cis rs11098499 0.863 rs7657849 chr4:120455494 T/C cg24375607 chr4:120327624 NA 0.47 7.05 0.36 1.06e-11 Corneal astigmatism; CRC cis rs10927875 0.541 rs1763599 chr1:16342602 C/T cg10494257 chr1:16342123 HSPB7 0.45 6.27 0.33 1.1e-9 Dilated cardiomyopathy; CRC cis rs9916302 0.904 rs650106 chr17:37451559 A/G cg00129232 chr17:37814104 STARD3 0.55 8.26 0.41 3.49e-15 Glomerular filtration rate (creatinine); CRC cis rs912057 0.632 rs1294432 chr6:6745027 C/T cg06612196 chr6:6737390 NA 0.54 8.59 0.43 3.5e-16 Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction); CRC cis rs2120019 1.000 rs2083731 chr15:75368538 A/C cg17294928 chr15:75287854 SCAMP5 -0.73 -10.9 -0.51 8.26e-24 Blood trace element (Zn levels); CRC cis rs10229583 0.527 rs10249616 chr7:127399500 A/G cg01233922 chr7:127693937 SND1 -0.54 -8.11 -0.41 1.05e-14 Type 2 diabetes; CRC trans rs10838798 0.563 rs11039516 chr11:48124157 T/A cg21153622 chr11:89784906 NA -0.45 -7.09 -0.36 8.43e-12 Height; CRC cis rs1448094 0.511 rs61930035 chr12:86153695 G/A cg25456477 chr12:86230367 RASSF9 0.39 6.45 0.34 3.89e-10 Major depressive disorder; CRC cis rs7811142 1.000 rs1000215 chr7:100004543 A/G cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.15 17.69 0.7 1.16e-49 Platelet count; CRC cis rs6121246 0.909 rs1994249 chr20:30287593 C/T cg13852791 chr20:30311386 BCL2L1 0.68 10.95 0.52 5.15e-24 Mean corpuscular hemoglobin; CRC cis rs4713118 0.629 rs149899 chr6:28019979 C/T cg15845792 chr6:28175446 NA 0.9 13.11 0.59 6.83e-32 Parkinson's disease; CRC cis rs17767294 0.612 rs12332927 chr6:27955115 T/C cg03623178 chr6:28175578 NA 0.65 6.96 0.36 1.83e-11 Parkinson's disease; CRC cis rs758324 0.947 rs6596040 chr5:131198777 C/T cg06307176 chr5:131281290 NA 0.43 6.3 0.33 9.35e-10 Alzheimer's disease in APOE e4- carriers; CRC cis rs8078723 0.714 rs9915252 chr17:38145088 C/G cg17344932 chr17:38183730 MED24;SNORD124 0.48 7.94 0.4 3.33e-14 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); CRC cis rs9910055 0.960 rs9911991 chr17:42278916 G/C cg13607699 chr17:42295918 UBTF 0.56 7.7 0.39 1.65e-13 Total body bone mineral density; CRC cis rs3749237 0.595 rs3924462 chr3:49524236 T/G cg02487422 chr3:49467188 NICN1 0.43 6.91 0.36 2.5e-11 Resting heart rate; CRC cis rs2289328 0.823 rs35565646 chr15:40660515 G/A cg13931752 chr15:40660718 DISP2 0.48 5.91 0.31 8.39e-9 Intelligence (multi-trait analysis);Cognitive ability;Cognitive ability (multi-trait analysis); CRC cis rs2637266 0.538 rs11001818 chr10:78313936 A/T cg18941641 chr10:78392320 NA -0.36 -5.9 -0.31 9.19e-9 Pulmonary function; CRC cis rs7773004 0.936 rs6917995 chr6:26327814 T/C cg00631329 chr6:26305371 NA -0.46 -7.61 -0.39 2.89e-13 Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for body mass index;Waist circumference adjusted for BMI in non-smokers;Waist circumference adjusted for BMI (adjusted for smoking behaviour); CRC trans rs4650994 0.507 rs12405456 chr1:178512331 T/G cg05059571 chr16:84539110 KIAA1609 -0.65 -9.21 -0.45 3.97e-18 HDL cholesterol levels;HDL cholesterol; CRC cis rs2576037 0.899 rs2060417 chr18:44576486 C/A cg07416455 chr18:44543612 TCEB3CL;KATNAL2 0.53 7.63 0.39 2.52e-13 Personality dimensions; CRC cis rs7618915 0.547 rs3774365 chr3:52642487 T/C cg10802521 chr3:52805072 NEK4 -0.58 -9.03 -0.45 1.5e-17 Bipolar disorder; CRC cis rs2806561 0.765 rs4333826 chr1:23517514 C/T cg12483005 chr1:23474871 LUZP1 0.49 7.15 0.37 5.58e-12 Height; CRC cis rs9326248 0.861 rs1871757 chr11:117030581 A/T cg26566898 chr11:117069891 TAGLN 0.38 6.91 0.36 2.47e-11 Blood protein levels; CRC cis rs4547160 0.572 rs1032494 chr12:63473125 A/G cg26727693 chr12:63544175 AVPR1A -0.43 -7.76 -0.39 1.08e-13 Morning vs. evening chronotype; CRC cis rs10464366 0.544 rs6952466 chr7:39155032 A/T cg10621924 chr7:39171070 POU6F2 0.41 5.64 0.3 3.73e-8 IgG glycosylation; CRC cis rs3096299 0.754 rs2965816 chr16:89514183 G/T cg01788221 chr16:89496183 ANKRD11 0.4 6.03 0.32 4.38e-9 Multiple myeloma (IgH translocation); CRC cis rs1552244 0.554 rs6768339 chr3:10006079 G/T cg02579736 chr3:10068473 FANCD2;CIDECP -0.64 -8.85 -0.44 5.44e-17 Alzheimer's disease; CRC cis rs10986311 0.775 rs1007185 chr9:127136644 G/C cg14243010 chr9:127117328 LOC100129034;PSMB7 -0.4 -6.03 -0.32 4.41e-9 Vitiligo; CRC cis rs992157 0.764 rs62183964 chr2:219186592 G/A cg04880052 chr2:219191631 PNKD 0.4 6.1 0.32 3.01e-9 Colorectal cancer; CRC cis rs7193541 0.965 rs28616016 chr16:74676964 T/C cg01733217 chr16:74700730 RFWD3 0.86 15.81 0.66 2.9e-42 Multiple myeloma; CRC cis rs9916302 0.752 rs12150047 chr17:37601755 A/G cg15445000 chr17:37608096 MED1 0.36 6.27 0.33 1.14e-9 Glomerular filtration rate (creatinine); CRC cis rs3087591 0.821 rs1034705 chr17:29536133 C/G cg24425628 chr17:29625626 OMG;NF1 -0.83 -16.16 -0.67 1.21e-43 Hip circumference; CRC cis rs9368481 0.761 rs9348746 chr6:26970357 C/G cg18867708 chr6:26865862 GUSBL1 -0.42 -5.98 -0.31 5.82e-9 Autism spectrum disorder or schizophrenia; CRC cis rs12519773 0.597 rs4308464 chr5:92468867 G/C cg18783429 chr5:92414398 NA 0.3 6.4 0.33 5.48e-10 Migraine; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg11028609 chr22:50312261 ALG12;CRELD2 0.4 5.96 0.31 6.53e-9 Response to antipsychotic treatment; CRC cis rs7258465 1.000 rs10405636 chr19:18538742 A/C cg06462663 chr19:18546047 ISYNA1 0.5 7.4 0.38 1.16e-12 Breast cancer; CRC cis rs7772486 0.875 rs2748485 chr6:146332421 T/C cg23711669 chr6:146136114 FBXO30 0.63 10.6 0.5 8.82e-23 Lobe attachment (rater-scored or self-reported); CRC cis rs11229555 0.574 rs66573492 chr11:58183797 G/A cg15696309 chr11:58395628 NA -0.81 -10.31 -0.49 8.83e-22 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; CRC cis rs9302635 0.678 rs8054585 chr16:72225314 G/A cg23815491 chr16:72088622 HP 0.53 6.89 0.36 2.86e-11 Blood protein levels; CRC cis rs8005677 1.000 rs8005677 chr14:23376678 T/C cg25600027 chr14:23388339 RBM23 -0.53 -8.37 -0.42 1.63e-15 Cognitive ability (multi-trait analysis); CRC cis rs875971 0.862 rs6460307 chr7:66060871 A/G cg00343986 chr7:65444356 GUSB 0.47 6.61 0.34 1.57e-10 Aortic root size; CRC cis rs10782582 0.593 rs12131493 chr1:76139172 G/A cg03433033 chr1:76189801 ACADM -0.41 -5.93 -0.31 7.53e-9 Daytime sleep phenotypes; CRC cis rs10751667 0.666 rs7395321 chr11:940280 C/T ch.11.42038R chr11:967971 AP2A2 0.58 9.85 0.48 3.1e-20 Alzheimer's disease (late onset); CRC cis rs4728302 0.869 rs958405 chr7:133597151 A/G cg03336402 chr7:133662267 EXOC4 -0.44 -6.33 -0.33 8.01e-10 Intelligence;Intelligence (multi-trait analysis); CRC cis rs57221529 0.709 rs72707023 chr5:667620 G/A cg09021430 chr5:549028 NA -0.69 -7.26 -0.37 2.85e-12 Lung disease severity in cystic fibrosis; CRC cis rs13082711 0.911 rs13089870 chr3:27447626 C/T cg02860705 chr3:27208620 NA 0.59 8.56 0.43 4.53e-16 Systolic blood pressure;Diastolic blood pressure;Blood pressure; CRC trans rs2303319 0.504 rs56026147 chr2:162614089 T/C cg04551154 chr10:95462393 C10orf4 -0.75 -6.37 -0.33 6.43e-10 Cognitive function; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg04915425 chr11:47236385 DDB2 0.49 6.18 0.32 1.94e-9 Thyroid stimulating hormone; CRC cis rs1862618 0.853 rs832582 chr5:56177743 G/A cg22800045 chr5:56110881 MAP3K1 0.62 6.64 0.34 1.29e-10 Initial pursuit acceleration; CRC cis rs10504229 0.683 rs6995355 chr8:58113870 C/T cg05313129 chr8:58192883 C8orf71 -0.43 -6.0 -0.31 5.07e-9 Developmental language disorder (linguistic errors); CRC cis rs629535 0.773 rs489206 chr8:70064883 T/C cg26132723 chr8:70041827 NA 0.36 5.82 0.31 1.41e-8 Dupuytren's disease; CRC cis rs2549003 0.674 rs960757 chr5:131826310 G/A cg02551604 chr5:131831745 NA -0.6 -9.36 -0.46 1.26e-18 Asthma (sex interaction); CRC cis rs11148252 0.846 rs9379 chr13:53050479 G/A cg02158880 chr13:53174818 NA 0.5 7.51 0.38 5.53e-13 Lewy body disease; CRC cis rs911119 0.954 rs2405367 chr20:23622880 A/G cg16589663 chr20:23618590 CST3 -0.63 -8.68 -0.43 1.87e-16 Chronic kidney disease; CRC trans rs931812 0.964 rs2102290 chr8:101919844 G/C cg20993868 chr7:22813445 NA 0.43 8.07 0.41 1.33e-14 Attention deficit hyperactivity disorder and conduct disorder; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg11265468 chr6:17987657 KIF13A 0.38 6.04 0.32 4.05e-9 Liver disease severity in Alagille syndrome; CRC cis rs9467711 0.606 rs2235251 chr6:26431982 C/T cg14345882 chr6:26364793 BTN3A2 0.7 5.67 0.3 3.1e-8 Autism spectrum disorder or schizophrenia; CRC cis rs8177253 1.000 rs1358023 chr3:133484393 T/C cg11941060 chr3:133502564 NA -0.58 -10.08 -0.49 5.23e-21 Iron status biomarkers; CRC cis rs8105895 0.877 rs2359833 chr19:22242221 T/G cg02657401 chr19:22469223 NA -0.34 -5.65 -0.3 3.56e-8 Body mass index (change over time); CRC cis rs9296092 0.538 rs62407565 chr6:33535739 A/G cg13560919 chr6:33536144 NA -0.47 -6.72 -0.35 8.26e-11 Age at smoking initiation in chronic obstructive pulmonary disease; CRC cis rs17253792 0.822 rs12100753 chr14:56042870 G/A cg01858014 chr14:56050164 KTN1 -0.9 -7.44 -0.38 8.61e-13 Putamen volume; CRC cis rs12898370 0.561 rs34129891 chr15:77481210 T/C cg10437265 chr15:77819839 NA 0.53 5.93 0.31 7.55e-9 Risky sexual behaviors (alcohol dependence interaction); CRC trans rs7027930 0.761 rs2131781 chr9:561426 T/A cg27061366 chr19:13044373 FARSA 0.52 6.1 0.32 2.93e-9 Pulmonary function decline; CRC trans rs2303319 0.504 rs62189055 chr2:162625749 C/A cg23919916 chr10:103825097 HPS6 -0.69 -5.99 -0.31 5.59e-9 Cognitive function; CRC cis rs3789045 0.615 rs11240748 chr1:204453320 C/T cg17419461 chr1:204415978 PIK3C2B -0.62 -9.22 -0.45 3.52e-18 Educational attainment (college completion); CRC cis rs6840360 0.571 rs62327268 chr4:152522326 T/A cg09659197 chr4:152720779 NA 0.32 5.81 0.31 1.44e-8 Intelligence (multi-trait analysis); CRC cis rs1046896 0.553 rs9893885 chr17:80837107 C/T cg03160526 chr17:80928410 B3GNTL1 0.58 7.76 0.39 1.06e-13 Glycated hemoglobin levels; CRC cis rs1865760 0.613 rs2071300 chr6:25914572 C/T cg16482183 chr6:26056742 HIST1H1C 0.42 6.14 0.32 2.31e-9 Height; CRC cis rs9926296 0.568 rs4420527 chr16:89814188 C/T cg04287289 chr16:89883240 FANCA -0.81 -14.36 -0.62 1.24e-36 Vitiligo; CRC cis rs4713118 0.615 rs9295747 chr6:27736993 G/T cg02683197 chr6:28174875 NA -0.61 -8.58 -0.43 3.87e-16 Parkinson's disease; CRC cis rs3793683 0.928 rs2148666 chr10:134553785 A/G cg26818010 chr10:134567672 INPP5A -0.43 -6.99 -0.36 1.56e-11 Migraine; CRC cis rs10504229 0.593 rs77607045 chr8:58010464 T/C cg02290350 chr8:58132656 NA -0.51 -5.89 -0.31 9.42e-9 Developmental language disorder (linguistic errors); CRC cis rs270601 0.690 rs162907 chr5:131580152 A/G cg11843238 chr5:131593191 PDLIM4 -0.54 -9.85 -0.48 3.13e-20 Acylcarnitine levels; CRC cis rs11229555 0.574 rs12271501 chr11:58214969 T/C cg15696309 chr11:58395628 NA -0.82 -10.31 -0.49 8.59e-22 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; CRC cis rs9902453 0.904 rs12936302 chr17:28349476 G/A cg26525008 chr17:28256777 EFCAB5;SSH2 -0.72 -12.08 -0.55 4.55e-28 Coffee consumption (cups per day); CRC cis rs6545883 0.507 rs4411680 chr2:61584105 A/C cg10580144 chr2:61372316 C2orf74 -0.35 -7.84 -0.4 6.23e-14 Tuberculosis; CRC cis rs6582630 0.519 rs80226845 chr12:38528231 C/A cg13010199 chr12:38710504 ALG10B 0.49 6.54 0.34 2.31e-10 Drug-induced liver injury (flucloxacillin); CRC cis rs7618501 0.521 rs3796386 chr3:49899795 G/A cg24110177 chr3:50126178 RBM5 -0.61 -9.23 -0.45 3.34e-18 Intelligence (multi-trait analysis); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg13514538 chr8:144942538 EPPK1 -0.4 -6.58 -0.34 1.91e-10 Liver disease severity in Alagille syndrome; CRC cis rs2404602 1.000 rs2120107 chr15:76869789 A/G cg22467129 chr15:76604101 ETFA -0.34 -5.79 -0.3 1.66e-8 Blood metabolite levels; CRC cis rs3862260 0.509 rs3795663 chr1:120165187 G/A cg11530693 chr1:120165357 ZNF697 0.61 9.64 0.47 1.54e-19 Systemic lupus erythematosus; CRC cis rs9902453 0.791 rs3115090 chr17:28035014 C/T cg26525008 chr17:28256777 EFCAB5;SSH2 0.69 11.45 0.53 9.06e-26 Coffee consumption (cups per day); CRC cis rs6762 0.748 rs7929032 chr11:839078 G/A cg16425592 chr11:842748 TSPAN4;POLR2L -0.55 -8.2 -0.41 5.53e-15 Mean platelet volume; CRC cis rs4665809 0.590 rs2289019 chr2:26420809 G/C cg04944784 chr2:26401820 FAM59B -0.82 -10.57 -0.5 1.14e-22 Gut microbiome composition (summer); CRC cis rs801193 0.591 rs2707839 chr7:66193084 A/G cg18876405 chr7:65276391 NA 0.5 8.23 0.41 4.47e-15 Aortic root size; CRC cis rs877282 1.000 rs12773872 chr10:771939 T/C cg17470449 chr10:769945 NA 0.63 8.43 0.42 1.11e-15 Uric acid levels; CRC cis rs9902453 0.967 rs12602065 chr17:28482488 A/C cg26525008 chr17:28256777 EFCAB5;SSH2 0.58 9.14 0.45 6.59e-18 Coffee consumption (cups per day); CRC cis rs6951245 0.872 rs11768486 chr7:1101290 C/A cg03188948 chr7:1209495 NA 0.65 6.84 0.35 3.8e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs3736485 0.844 rs17524813 chr15:51793533 G/T cg08986416 chr15:51914746 DMXL2 -0.45 -6.42 -0.33 4.67e-10 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs6540559 0.611 rs6540563 chr1:210019858 C/G cg21951975 chr1:209979733 IRF6 0.46 5.6 0.3 4.48e-8 Cleft lip with or without cleft palate; CRC cis rs62244186 0.545 rs725866 chr3:44765533 A/G cg11003573 chr3:44754125 ZNF502 -0.35 -6.25 -0.33 1.27e-9 Depressive symptoms; CRC cis rs1691799 0.836 rs1184552 chr12:66756215 A/G cg16791601 chr12:66731901 HELB -0.72 -12.56 -0.57 7.95e-30 White blood cell count (basophil); CRC cis rs7224685 0.501 rs781823 chr17:3966280 G/C cg05562828 chr17:3906858 NA 0.67 12.55 0.57 8.33e-30 Type 2 diabetes; CRC cis rs1580019 0.587 rs34488151 chr7:32548146 A/G cg14728415 chr7:32535168 LSM5;AVL9 0.45 6.48 0.34 3.28e-10 Cognitive ability; CRC cis rs6570726 0.599 rs9376951 chr6:145898911 C/T cg13319975 chr6:146136371 FBXO30 -0.6 -8.56 -0.43 4.46e-16 Lobe attachment (rater-scored or self-reported); CRC cis rs12325245 0.536 rs8058781 chr16:58653838 G/A cg21335942 chr16:58549945 SETD6 0.86 5.72 0.3 2.39e-8 Schizophrenia; CRC cis rs2882667 0.858 rs6596460 chr5:138414180 G/A cg04439458 chr5:138467593 SIL1 -0.33 -5.87 -0.31 1.09e-8 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs561341 1.000 rs530209 chr17:30315287 A/G cg23018236 chr17:30244563 NA -0.67 -8.02 -0.4 1.83e-14 Hip circumference adjusted for BMI; CRC cis rs3791406 1.000 rs3791412 chr2:240031088 A/G cg14550559 chr2:240039617 HDAC4 -0.51 -7.62 -0.39 2.8e-13 Skin aging (microtopography measurement); CRC cis rs7429990 0.932 rs11720151 chr3:48140634 G/A cg11946769 chr3:48343235 NME6 -0.48 -6.29 -0.33 1.02e-9 Educational attainment (years of education); CRC cis rs951366 0.903 rs823114 chr1:205719532 G/A cg11965913 chr1:205819406 PM20D1 0.45 6.87 0.35 3.14e-11 Menarche (age at onset); CRC cis rs9513593 1.000 rs723090 chr13:100017105 A/G cg21788972 chr13:99853209 UBAC2 0.46 5.84 0.31 1.27e-8 Psoriasis; CRC cis rs950169 0.919 rs12915589 chr15:84734464 T/C cg17507749 chr15:85114479 UBE2QP1 0.77 11.93 0.55 1.64e-27 Schizophrenia; CRC trans rs925098 0.577 rs2724470 chr4:17996046 A/G cg17524151 chr16:475494 RAB11FIP3 -0.43 -6.28 -0.33 1.05e-9 Birth weight;Height; CRC cis rs4713118 0.662 rs175954 chr6:28011585 A/G cg02631126 chr6:28058918 ZSCAN12L1 0.25 5.63 0.3 3.77e-8 Parkinson's disease; CRC cis rs11105298 0.891 rs6538190 chr12:89885942 T/C cg00757033 chr12:89920650 WDR51B 0.38 6.41 0.33 5.02e-10 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; CRC cis rs765787 0.530 rs11854690 chr15:45516016 C/T cg24006582 chr15:45444508 DUOX1 -0.57 -8.75 -0.43 1.15e-16 Uric acid levels; CRC cis rs2836974 0.897 rs1984022 chr21:40596085 G/A cg11644478 chr21:40555479 PSMG1 0.79 12.03 0.55 7.39e-28 Cognitive function; CRC cis rs73206853 0.841 rs56117211 chr12:111123485 T/G cg12870014 chr12:110450643 ANKRD13A 0.68 6.37 0.33 6.39e-10 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC cis rs1580019 0.587 rs7804457 chr7:32557981 A/G cg07520158 chr7:32535189 LSM5;AVL9 0.53 7.87 0.4 5.26e-14 Cognitive ability; CRC cis rs534126 0.885 rs10274425 chr7:143016166 A/G cg04182207 chr7:143013161 CLCN1 0.34 6.32 0.33 8.58e-10 Cancer; CRC cis rs3820068 0.705 rs4645992 chr1:15849742 G/T cg27534772 chr1:16042836 PLEKHM2 0.43 6.95 0.36 1.92e-11 Systolic blood pressure; CRC cis rs4604732 0.631 rs76761880 chr1:247626377 T/A cg12754571 chr1:247694271 LOC148824;OR2C3 0.41 5.78 0.3 1.74e-8 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CRC cis rs2180341 0.920 rs9401951 chr6:127671632 A/C cg27446573 chr6:127587934 RNF146 0.97 13.77 0.6 2.17e-34 Breast cancer; CRC cis rs10256972 0.967 rs1881122 chr7:1040946 A/T cg07308232 chr7:1071921 C7orf50 -0.43 -6.01 -0.31 4.95e-9 Longevity;Endometriosis; CRC cis rs9318086 0.648 rs7331047 chr13:24467342 T/C cg25267304 chr13:24462978 PCOTH;MIPEP 0.66 10.59 0.5 9.54e-23 Myopia (pathological); CRC cis rs2839186 0.558 rs2968 chr21:47608580 C/T cg26721908 chr21:47610096 LSS 0.45 7.4 0.38 1.16e-12 Testicular germ cell tumor; CRC cis rs1008375 0.897 rs1006723 chr4:17618524 G/A cg16339924 chr4:17578868 LAP3 0.52 6.99 0.36 1.5e-11 Parasitemia in Tripanosoma cruzi seropositivity; CRC trans rs8073060 0.544 rs7211724 chr17:33993414 C/G cg19694781 chr19:47549865 TMEM160 -1.1 -15.87 -0.66 1.67e-42 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; CRC cis rs12024301 0.557 rs6674310 chr1:183603471 C/G cg11505048 chr1:183622726 RGL1;APOBEC4 0.75 6.81 0.35 4.6e-11 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs2795502 0.873 rs3121327 chr10:43388285 G/A cg27426351 chr10:43362370 NA 0.61 7.45 0.38 8.48e-13 Blood protein levels; CRC cis rs4713118 0.868 rs742047 chr6:27739380 A/G cg15845792 chr6:28175446 NA 0.7 7.72 0.39 1.43e-13 Parkinson's disease; CRC cis rs12681287 0.640 rs12544463 chr8:87481114 A/G cg27223183 chr8:87520930 FAM82B -0.53 -7.52 -0.38 5.31e-13 Caudate activity during reward; CRC cis rs7727544 0.625 rs3091338 chr5:131402738 C/T cg18758796 chr5:131593413 PDLIM4 0.37 6.02 0.32 4.62e-9 Blood metabolite levels; CRC cis rs9443645 0.901 rs9341754 chr6:79584973 A/C cg09184832 chr6:79620586 NA -0.52 -9.73 -0.47 8.04e-20 Intelligence (multi-trait analysis); CRC cis rs727479 0.543 rs4324076 chr15:51510868 A/C cg19946085 chr15:51559439 CYP19A1 -0.32 -6.45 -0.34 3.93e-10 Estradiol levels; CRC cis rs6951245 0.872 rs76161580 chr7:1100307 G/T cg03188948 chr7:1209495 NA 0.65 6.84 0.35 3.8e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs6502050 0.835 rs12051747 chr17:80114814 T/C cg13198984 chr17:80129470 CCDC57 0.45 8.05 0.41 1.51e-14 Life satisfaction; CRC cis rs7666738 0.830 rs7662948 chr4:99020132 G/C cg17366294 chr4:99064904 C4orf37 0.43 7.29 0.37 2.27e-12 Colonoscopy-negative controls vs population controls; CRC cis rs6502050 0.835 rs34867501 chr17:80121358 T/C cg19223190 chr17:80058835 NA 0.39 6.23 0.32 1.43e-9 Life satisfaction; CRC cis rs7666738 0.830 rs59751489 chr4:98933802 A/G cg17366294 chr4:99064904 C4orf37 0.43 7.32 0.37 1.95e-12 Colonoscopy-negative controls vs population controls; CRC cis rs9303401 1.000 rs7218362 chr17:56888299 A/G cg12560992 chr17:57184187 TRIM37 0.44 5.85 0.31 1.19e-8 Cognitive test performance; CRC cis rs12701220 0.655 rs7799656 chr7:1140515 C/T cg02733842 chr7:1102375 C7orf50 -0.56 -7.06 -0.36 9.85e-12 Bronchopulmonary dysplasia; CRC cis rs2882667 0.861 rs13176902 chr5:138393329 T/C cg09476006 chr5:138032270 NA 0.44 7.39 0.38 1.21e-12 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs10206020 0.921 rs72778009 chr2:1573322 G/T cg12573674 chr2:1569213 NA -0.82 -10.96 -0.52 5.02e-24 IgG glycosylation; CRC trans rs6984305 0.541 rs17716118 chr8:9180134 A/G cg17124844 chr8:1624822 DLGAP2 -0.55 -6.52 -0.34 2.64e-10 Liver enzyme levels (alkaline phosphatase); CRC cis rs911119 0.657 rs6114214 chr20:23627924 A/T cg16589663 chr20:23618590 CST3 0.58 7.22 0.37 3.58e-12 Chronic kidney disease; CRC cis rs1448094 0.512 rs7302741 chr12:86237127 C/T cg02569458 chr12:86230093 RASSF9 0.45 7.68 0.39 1.84e-13 Major depressive disorder; CRC cis rs769267 0.965 rs2023882 chr19:19405405 T/C cg01262667 chr19:19385393 TM6SF2 0.36 5.92 0.31 7.95e-9 Tonsillectomy; CRC cis rs1223397 0.938 rs13205692 chr6:13291560 C/T cg20827128 chr6:13274284 PHACTR1 0.56 6.56 0.34 2.05e-10 Blood pressure; CRC cis rs6459804 1.000 rs6459804 chr7:157510195 C/T cg05585630 chr7:157510462 PTPRN2 -0.42 -6.61 -0.34 1.54e-10 Bipolar disorder and schizophrenia; CRC cis rs1867631 0.585 rs6694782 chr1:67126762 C/T cg02459107 chr1:67143332 SGIP1 -0.36 -6.31 -0.33 8.85e-10 Menopause (age at onset); CRC cis rs965469 1.000 rs6051831 chr20:3373712 G/T cg25506879 chr20:3388711 C20orf194 0.4 5.8 0.3 1.52e-8 IFN-related cytopenia; CRC cis rs4631830 0.683 rs10763193 chr10:51504938 G/A cg20129853 chr10:51489980 NA 0.35 5.78 0.3 1.7e-8 Prostate-specific antigen levels; CRC cis rs9926296 0.568 rs4420527 chr16:89814188 C/T cg27121462 chr16:89883253 FANCA -0.57 -8.9 -0.44 3.76e-17 Vitiligo; CRC cis rs7731657 0.537 rs2419934 chr5:130295768 T/C cg08523029 chr5:130500466 HINT1 -0.49 -6.17 -0.32 2.02e-9 Fasting plasma glucose; CRC cis rs7615952 0.641 rs7632497 chr3:125783086 A/C cg04553112 chr3:125709451 NA -0.51 -5.91 -0.31 8.52e-9 Blood pressure (smoking interaction); CRC trans rs9650657 0.770 rs6601529 chr8:10670550 A/G cg06636001 chr8:8085503 FLJ10661 -0.42 -6.06 -0.32 3.74e-9 Neuroticism; CRC cis rs2228479 0.717 rs1061647 chr16:89806063 G/C cg19635926 chr16:89946313 TCF25 0.68 6.15 0.32 2.2e-9 Skin colour saturation; CRC cis rs11997175 0.574 rs4733456 chr8:33656359 C/T cg04338863 chr8:33670619 NA 0.41 7.28 0.37 2.48e-12 Body mass index; CRC cis rs6903823 0.508 rs1150726 chr6:28243042 C/T cg21251018 chr6:28226885 NKAPL 0.54 9.16 0.45 5.65e-18 Pulmonary function; CRC cis rs9549328 0.700 rs3011474 chr13:113617865 T/C cg24588162 chr13:113633484 MCF2L 0.36 6.39 0.33 5.65e-10 Systolic blood pressure; CRC cis rs1943345 0.519 rs11233504 chr11:82886525 A/G cg07047830 chr11:82868014 PCF11 0.53 7.8 0.39 8.47e-14 Obesity-related traits; CRC cis rs2251381 0.523 rs2832306 chr21:30754468 C/T cg24692254 chr21:30365293 RNF160 -0.55 -8.41 -0.42 1.28e-15 Selective IgA deficiency; CRC trans rs6561151 0.957 rs1932990 chr13:44460242 C/T cg17145862 chr1:211918768 LPGAT1 0.5 7.11 0.36 7.22e-12 Crohn's disease; CRC cis rs2836950 0.501 rs35994303 chr21:40686020 C/T cg11644478 chr21:40555479 PSMG1 -0.45 -6.57 -0.34 2e-10 Menarche (age at onset); CRC cis rs4665809 0.878 rs35709953 chr2:26334997 G/A cg22920501 chr2:26401640 FAM59B 0.56 6.73 0.35 7.73e-11 Gut microbiome composition (summer); CRC trans rs4263408 0.934 rs9683743 chr4:39703194 A/C cg14221884 chr12:63328524 PPM1H -0.43 -6.38 -0.33 6.18e-10 Plasma amyloid beta peptide concentrations (ABx-40); CRC cis rs10911363 0.592 rs4047798 chr1:183421406 C/T cg09173681 chr1:183549694 NCF2 -0.78 -10.56 -0.5 1.19e-22 Systemic lupus erythematosus; CRC cis rs7927592 0.913 rs12294029 chr11:68257059 A/C cg16797656 chr11:68205561 LRP5 0.39 6.21 0.32 1.59e-9 Total body bone mineral density; CRC cis rs6543140 0.964 rs11903551 chr2:103084181 C/G cg03938978 chr2:103052716 IL18RAP 0.41 6.52 0.34 2.71e-10 Blood protein levels; CRC cis rs4819052 0.840 rs914217 chr21:46698299 A/G cg11663144 chr21:46675770 NA -0.78 -10.97 -0.52 4.54e-24 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs896854 0.654 rs4735340 chr8:95976251 A/T cg13393036 chr8:95962371 TP53INP1 -0.54 -9.29 -0.46 2.16e-18 Type 2 diabetes; CRC cis rs929354 0.772 rs1182365 chr7:157017255 A/T cg05182265 chr7:156933206 UBE3C 0.77 14.67 0.63 7.87e-38 Body mass index; CRC cis rs17376456 0.877 rs10073039 chr5:93467709 A/G cg09848695 chr5:92956644 FAM172A;MIR2277 0.63 5.85 0.31 1.19e-8 Diabetic retinopathy; CRC cis rs9399135 0.967 rs12526055 chr6:135325918 C/T cg22676075 chr6:135203613 NA 0.41 6.33 0.33 7.94e-10 Red blood cell count; CRC cis rs12474201 0.928 rs12998753 chr2:46938385 A/G cg06386533 chr2:46925753 SOCS5 0.83 13.73 0.6 3.08e-34 Height; CRC cis rs6933660 0.646 rs3816778 chr6:151773353 G/C cg17179660 chr6:151773299 C6orf211;RMND1 -0.45 -6.93 -0.36 2.29e-11 Menarche (age at onset); CRC cis rs7666738 0.830 rs62321570 chr4:98984276 G/A cg17366294 chr4:99064904 C4orf37 0.43 7.33 0.37 1.76e-12 Colonoscopy-negative controls vs population controls; CRC trans rs61931739 0.534 rs6488189 chr12:33995865 C/T cg26384229 chr12:38710491 ALG10B 0.53 6.73 0.35 7.37e-11 Morning vs. evening chronotype; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg07805724 chr3:69062774 C3orf64 0.47 6.58 0.34 1.85e-10 Anxiety disorder; CRC cis rs2976388 0.506 rs2572902 chr8:143791387 A/G cg05569086 chr8:143859399 LYNX1 0.4 6.96 0.36 1.91e-11 Urinary tract infection frequency; CRC cis rs10504073 0.565 rs974780 chr8:49930976 G/A cg00325661 chr8:49890786 NA 0.64 11.52 0.54 5.1e-26 Blood metabolite ratios; CRC cis rs473651 0.901 rs563282 chr2:239329736 T/C cg21699342 chr2:239360505 ASB1 0.53 9.12 0.45 7.9e-18 Multiple system atrophy; CRC trans rs4332037 0.707 rs73046323 chr7:1882795 G/A cg11693508 chr17:37793320 STARD3 0.63 8.09 0.41 1.18e-14 Bipolar disorder; CRC cis rs6460942 0.659 rs28366613 chr7:12512167 C/T cg06484146 chr7:12443880 VWDE -0.57 -5.9 -0.31 9.2e-9 Coronary artery disease; CRC cis rs9372498 0.505 rs62422250 chr6:118990182 T/C cg22561889 chr6:118971681 C6orf204 0.55 6.59 0.34 1.73e-10 Diastolic blood pressure; CRC cis rs8070740 0.947 rs3809842 chr17:5329199 C/T cg25236894 chr17:5323110 RPAIN;NUP88 0.48 6.98 0.36 1.65e-11 Menopause (age at onset); CRC cis rs6546550 0.901 rs34586537 chr2:70163316 G/T cg02498382 chr2:70120550 SNRNP27 0.55 9.43 0.46 7.48e-19 Prevalent atrial fibrillation; CRC cis rs875971 0.862 rs7783779 chr7:65796626 A/G cg18252515 chr7:66147081 NA 0.41 5.73 0.3 2.3e-8 Aortic root size; CRC cis rs7937682 0.632 rs1045282 chr11:111754574 A/C cg19812747 chr11:111475976 SIK2 0.42 6.08 0.32 3.39e-9 Primary sclerosing cholangitis; CRC cis rs12983728 0.831 rs35081008 chr19:58662235 C/T cg21877656 chr19:58662188 ZNF329 0.7 7.66 0.39 2.13e-13 Cholesterol, total; CRC cis rs3768617 0.510 rs1886500 chr1:183095048 G/A ch.1.3577855R chr1:183094577 LAMC1 0.89 15.86 0.66 1.84e-42 Fuchs's corneal dystrophy; CRC cis rs798554 0.679 rs2533877 chr7:2882421 G/A cg19717773 chr7:2847554 GNA12 -0.44 -6.16 -0.32 2.14e-9 Height; CRC cis rs79387448 0.745 rs17027341 chr2:103136559 A/G cg09003973 chr2:102972529 NA 0.65 7.3 0.37 2.22e-12 Gut microbiota (bacterial taxa); CRC cis rs651907 0.557 rs13077925 chr3:101488181 T/A cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.58 7.83 0.4 6.82e-14 Colorectal cancer; CRC cis rs763121 0.853 rs9306329 chr22:39072454 C/T cg06544989 chr22:39130855 UNC84B 0.45 6.9 0.36 2.7e-11 Menopause (age at onset); CRC cis rs12701220 0.503 rs12702024 chr7:1129820 G/C cg00990874 chr7:1149470 C7orf50 -0.62 -7.3 -0.37 2.13e-12 Bronchopulmonary dysplasia; CRC cis rs1784581 0.588 rs6455789 chr6:162417948 C/T cg17173639 chr6:162384350 PARK2 0.6 9.72 0.47 8.36e-20 Itch intensity from mosquito bite; CRC cis rs9747201 0.925 rs62078748 chr17:80055325 C/T cg14673194 chr17:80132900 CCDC57 0.49 6.12 0.32 2.59e-9 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs72945132 0.882 rs17160762 chr11:70134766 A/G cg14191688 chr11:70257035 CTTN -0.44 -5.83 -0.31 1.34e-8 Coronary artery disease; CRC cis rs9916302 0.800 rs8081220 chr17:37473157 A/C cg07936489 chr17:37558343 FBXL20 0.8 11.89 0.55 2.31e-27 Glomerular filtration rate (creatinine); CRC cis rs4713118 0.824 rs9468225 chr6:27745719 T/G cg15786705 chr6:28176104 NA 0.56 7.35 0.38 1.55e-12 Parkinson's disease; CRC cis rs67478160 0.643 rs8005594 chr14:104279889 T/C cg01849466 chr14:104193079 ZFYVE21 -0.46 -8.12 -0.41 9.55e-15 Schizophrenia; CRC trans rs8123881 0.733 rs7268466 chr20:15810676 C/T cg18711617 chr17:49338392 MBTD1;UTP18 0.55 6.23 0.32 1.44e-9 Body mass index; CRC cis rs3091242 0.933 rs11249250 chr1:25767609 G/A cg02931644 chr1:25747376 RHCE 0.33 5.66 0.3 3.35e-8 Erythrocyte sedimentation rate; CRC cis rs1552244 0.882 rs13075842 chr3:10055813 A/C cg16606324 chr3:10149918 C3orf24 0.62 7.91 0.4 3.93e-14 Alzheimer's disease; CRC cis rs7786808 0.530 rs7785656 chr7:158184164 C/G cg09998033 chr7:158218633 PTPRN2 -0.63 -9.03 -0.45 1.52e-17 Obesity-related traits; CRC cis rs6459788 0.527 rs6980250 chr7:157228710 C/T cg06271696 chr7:157225062 NA -0.71 -12.93 -0.58 3.35e-31 Epstein-Barr virus copy number in lymphoblastoid cell lines; CRC cis rs896623 0.597 rs4455437 chr4:122136763 C/T cg19463078 chr4:122099598 TNIP3 -0.39 -5.94 -0.31 7.1e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs853679 0.517 rs9468297 chr6:28118874 G/T cg12273811 chr6:28175739 NA 0.73 9.16 0.45 5.8e-18 Depression; CRC cis rs28374715 0.510 rs8034073 chr15:41545613 A/C cg18705301 chr15:41695430 NDUFAF1 -0.52 -8.78 -0.44 9.05e-17 Ulcerative colitis; CRC cis rs1124376 1.000 rs9819628 chr3:20140837 A/G cg05072819 chr3:20081367 KAT2B -0.51 -6.23 -0.33 1.39e-9 Bipolar disorder and schizophrenia; CRC cis rs12701220 0.894 rs12539012 chr7:1052133 G/A cg26769984 chr7:1090371 C7orf50 0.69 9.17 0.45 5.21e-18 Bronchopulmonary dysplasia; CRC cis rs7615952 0.641 rs12495947 chr3:125771698 C/T cg15145296 chr3:125709740 NA -0.57 -6.75 -0.35 6.67e-11 Blood pressure (smoking interaction); CRC cis rs12620999 0.941 rs7593758 chr2:237980920 G/T cg23555395 chr2:238036564 NA -0.57 -9.47 -0.46 5.57e-19 Systemic lupus erythematosus; CRC cis rs7647973 1.000 rs9862534 chr3:49598064 A/G cg20833759 chr3:49053208 WDR6;DALRD3 0.54 8.31 0.42 2.47e-15 Menarche (age at onset); CRC cis rs13191362 0.935 rs7769048 chr6:163010040 T/A cg23758597 chr6:163146217 PARK2 -0.55 -6.12 -0.32 2.7e-9 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC trans rs1005277 0.540 rs1987431 chr10:37988887 T/C cg23533926 chr12:111358616 MYL2 -0.44 -6.48 -0.34 3.36e-10 Extrinsic epigenetic age acceleration; CRC cis rs9733 0.791 rs11800059 chr1:150651175 C/T cg17724175 chr1:150552817 MCL1 -0.46 -7.28 -0.37 2.5e-12 Tonsillectomy; CRC cis rs977987 0.843 rs4887820 chr16:75397287 C/T cg03315344 chr16:75512273 CHST6 0.54 9.07 0.45 1.13e-17 Dupuytren's disease; CRC cis rs6502050 0.835 rs12450189 chr17:80095128 A/C cg22110888 chr17:80059540 CCDC57 0.4 6.44 0.33 4.17e-10 Life satisfaction; CRC trans rs3780486 1.000 rs12342831 chr9:33124872 A/G cg20290983 chr6:43655470 MRPS18A 1.03 16.85 0.68 2.3e-46 IgG glycosylation; CRC cis rs8099014 0.814 rs4245272 chr18:56115145 T/A cg12907477 chr18:56117327 MIR122 0.46 5.96 0.31 6.58e-9 Platelet count; CRC cis rs6570726 0.791 rs370112 chr6:145859853 T/G cg23711669 chr6:146136114 FBXO30 0.76 13.16 0.59 4.72e-32 Lobe attachment (rater-scored or self-reported); CRC cis rs950169 1.000 rs79318564 chr15:84786150 G/A cg03959625 chr15:84868606 LOC388152 0.41 6.16 0.32 2.09e-9 Schizophrenia; CRC cis rs78456975 0.527 rs72778003 chr2:1571487 G/A cg26248373 chr2:1572462 NA -0.85 -11.89 -0.55 2.27e-27 Placebo response in major depressive disorder (% change in symptom score); CRC cis rs2120019 1.000 rs7162900 chr15:75368017 T/C cg11632617 chr15:75315747 PPCDC -0.56 -8.05 -0.41 1.52e-14 Blood trace element (Zn levels); CRC cis rs561341 1.000 rs546748 chr17:30324293 A/C cg19193384 chr17:30244184 NA -0.49 -6.73 -0.35 7.54e-11 Hip circumference adjusted for BMI; CRC cis rs875971 1.000 rs10244498 chr7:66116056 A/G cg00343986 chr7:65444356 GUSB 0.44 6.23 0.32 1.41e-9 Aortic root size; CRC cis rs6952808 0.825 rs34922657 chr7:1938655 C/T cg20295408 chr7:1910781 MAD1L1 -0.42 -5.85 -0.31 1.17e-8 Bipolar disorder and schizophrenia; CRC cis rs4713118 0.621 rs9295755 chr6:28033174 C/T cg12273811 chr6:28175739 NA -0.61 -7.89 -0.4 4.46e-14 Parkinson's disease; CRC cis rs8044868 0.566 rs3812984 chr16:72207797 C/T cg23815491 chr16:72088622 HP 0.42 6.2 0.32 1.71e-9 Body mass index (change over time) in cancer or chronic obstructive pulmonary disease;Body mass index (change over time) in cancer; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg02698600 chr1:201450009 NA 0.39 6.37 0.33 6.29e-10 Liver disease severity in Alagille syndrome; CRC cis rs7666738 0.791 rs6851549 chr4:99029827 G/A cg17366294 chr4:99064904 C4orf37 0.44 7.43 0.38 9.22e-13 Colonoscopy-negative controls vs population controls; CRC cis rs1008375 1.000 rs11724495 chr4:17621310 G/A cg16339924 chr4:17578868 LAP3 0.58 7.78 0.39 9.17e-14 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs17376456 0.877 rs12716460 chr5:93416733 A/G cg21475434 chr5:93447410 FAM172A 0.74 7.63 0.39 2.64e-13 Diabetic retinopathy; CRC cis rs7208859 0.673 rs2470251 chr17:29095061 T/C cg01831904 chr17:28903510 LRRC37B2 -0.52 -6.03 -0.32 4.33e-9 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs4936891 0.645 rs74858431 chr11:123902862 T/C cg22125253 chr11:123886957 OR10G4 0.4 7.44 0.38 8.86e-13 Male fertility; CRC cis rs1401999 0.966 rs2313212 chr3:183700928 A/G cg05044414 chr3:183734942 ABCC5 0.48 8.3 0.42 2.77e-15 Anterior chamber depth; CRC cis rs9911578 1.000 rs9904879 chr17:56864422 G/A cg12560992 chr17:57184187 TRIM37 0.9 16.6 0.68 2.13e-45 Intelligence (multi-trait analysis); CRC cis rs644799 0.526 rs693792 chr11:95622200 C/T cg03916912 chr11:95522834 CEP57;FAM76B 0.66 10.82 0.51 1.53e-23 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs9322193 0.926 rs9383546 chr6:150143879 T/A cg07701084 chr6:150067640 NUP43 0.47 6.56 0.34 2.07e-10 Lung cancer; CRC cis rs9341808 0.718 rs9443734 chr6:80820293 C/T cg08355045 chr6:80787529 NA 0.43 6.88 0.35 2.95e-11 Sitting height ratio; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg13967864 chr9:100396098 NCBP1;TSTD2 0.46 6.27 0.33 1.13e-9 Anxiety disorder; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg02007933 chr16:89767497 SPATA2L 0.53 7.25 0.37 3.04e-12 Anxiety disorder; CRC cis rs7119 0.717 rs12909645 chr15:77816819 A/T cg27398640 chr15:77910606 LINGO1 -0.43 -7.47 -0.38 7.13e-13 Type 2 diabetes; CRC cis rs7772486 0.875 rs9390372 chr6:146363638 G/C cg05347473 chr6:146136440 FBXO30 0.37 5.89 0.31 9.38e-9 Lobe attachment (rater-scored or self-reported); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg23612220 chr1:151129298 TNFAIP8L2 0.23 6.17 0.32 2.06e-9 Liver disease severity in Alagille syndrome; CRC cis rs9894429 0.646 rs7405937 chr17:79597811 G/A cg21984481 chr17:79567631 NPLOC4 -0.46 -7.98 -0.4 2.47e-14 Eye color traits; CRC cis rs68170813 0.559 rs7794598 chr7:106826381 C/T cg02696742 chr7:106810147 HBP1 -0.6 -7.06 -0.36 9.66e-12 Coronary artery disease; CRC trans rs11148252 0.564 rs2296350 chr13:52710044 T/C cg18335740 chr13:41363409 SLC25A15 0.53 7.93 0.4 3.43e-14 Lewy body disease; CRC cis rs6460942 0.591 rs4721082 chr7:12341804 A/G cg20607287 chr7:12443886 VWDE -0.55 -5.98 -0.31 5.94e-9 Coronary artery disease; CRC cis rs8032158 0.702 rs11632977 chr15:56131609 T/C cg02198044 chr15:56286336 NEDD4 -0.36 -5.76 -0.3 1.97e-8 Keloid; CRC cis rs2243480 1.000 rs160643 chr7:65558222 C/T cg18252515 chr7:66147081 NA -0.99 -12.6 -0.57 5.6e-30 Diabetic kidney disease; CRC cis rs2882667 0.690 rs288028 chr5:138221989 C/G cg09476006 chr5:138032270 NA 0.56 9.37 0.46 1.24e-18 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs2019137 0.868 rs3748916 chr2:113984033 C/T cg12889195 chr2:113992843 PAX8;LOC440839;LOC654433 -0.51 -7.35 -0.38 1.59e-12 Lymphocyte counts; CRC cis rs731174 0.959 rs11264092 chr1:38190625 T/C cg06917450 chr1:38156652 C1orf109 -0.49 -6.95 -0.36 1.92e-11 Prostate cancer (SNP x SNP interaction); CRC cis rs738322 0.555 rs5750547 chr22:38546700 A/G cg25457927 chr22:38595422 NA 0.36 7.2 0.37 4.18e-12 Cutaneous nevi; CRC cis rs2243480 1.000 rs316326 chr7:65609453 T/C cg18252515 chr7:66147081 NA -1.24 -14.76 -0.63 3.58e-38 Diabetic kidney disease; CRC trans rs11039798 0.588 rs10838923 chr11:48534864 C/G cg15704280 chr7:45808275 SEPT13 0.6 6.34 0.33 7.68e-10 Axial length; CRC cis rs853679 0.517 rs1904841 chr6:28108085 C/T cg12963246 chr6:28129442 ZNF389 0.5 5.9 0.31 8.91e-9 Depression; CRC cis rs6598955 0.724 rs10902737 chr1:26635716 G/A cg00852783 chr1:26633632 UBXN11 0.39 6.18 0.32 1.92e-9 Obesity-related traits; CRC cis rs6502050 0.842 rs7218075 chr17:80076808 C/G cg02741985 chr17:80059408 CCDC57 -0.45 -7.4 -0.38 1.17e-12 Life satisfaction; CRC trans rs9329221 0.537 rs13282106 chr8:9981900 G/T cg16141378 chr3:129829833 LOC729375 -0.41 -6.0 -0.31 5.07e-9 Neuroticism; CRC cis rs12477438 0.520 rs6542870 chr2:99796638 C/T cg26064155 chr2:99771622 LIPT1;TSGA10 0.87 15.96 0.66 7.31e-43 Chronic sinus infection; CRC cis rs4900538 0.821 rs8016191 chr14:102825340 G/A cg18135206 chr14:102964638 TECPR2 -0.97 -17.37 -0.69 2.04e-48 Mean corpuscular volume;Mean corpuscular hemoglobin; CRC cis rs2019137 0.560 rs7421852 chr2:113990261 G/A cg21550016 chr2:113992930 PAX8;LOC440839;LOC654433 0.65 9.75 0.47 6.84e-20 Lymphocyte counts; CRC trans rs10983614 1.000 rs7867776 chr9:120072627 A/G cg00387457 chr20:34639042 LOC647979 0.46 6.06 0.32 3.64e-9 Survival in pancreatic cancer; CRC cis rs7666738 0.830 rs60391193 chr4:98933912 T/G cg17366294 chr4:99064904 C4orf37 0.43 7.32 0.37 1.95e-12 Colonoscopy-negative controls vs population controls; CRC cis rs4954585 0.708 rs13034241 chr2:137021263 G/A cg05194412 chr2:137003533 NA 0.44 6.82 0.35 4.34e-11 Colorectal cancer; CRC cis rs1707322 0.682 rs10890334 chr1:46100378 A/T cg06784218 chr1:46089804 CCDC17 0.65 12.37 0.56 3.93e-29 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs9467773 0.620 rs2504571 chr6:26643435 C/T cg09904177 chr6:26538194 HMGN4 0.72 11.27 0.53 3.96e-25 Intelligence (multi-trait analysis); CRC cis rs7605827 0.930 rs11688071 chr2:15612626 T/G cg19274914 chr2:15703543 NA 0.38 5.89 0.31 9.63e-9 Educational attainment (years of education); CRC cis rs4268898 0.722 rs2288072 chr2:24390517 G/A cg06627628 chr2:24431161 ITSN2 0.41 6.04 0.32 4.11e-9 Asthma; CRC cis rs2985684 0.894 rs4900932 chr14:50022928 A/G cg04989706 chr14:50066350 PPIL5 -0.59 -8.42 -0.42 1.17e-15 Carotid intima media thickness; CRC cis rs875971 0.895 rs1974769 chr7:65950614 G/A cg18876405 chr7:65276391 NA 0.52 8.9 0.44 3.86e-17 Aortic root size; CRC cis rs17641971 0.684 rs11785391 chr8:49930203 G/T cg00325661 chr8:49890786 NA 0.36 6.33 0.33 8e-10 Blood metabolite levels; CRC cis rs853679 0.517 rs9380065 chr6:28144751 A/G cg15786705 chr6:28176104 NA 0.78 9.7 0.47 1.01e-19 Depression; CRC cis rs919433 0.680 rs7568250 chr2:198409611 G/A cg10820045 chr2:198174542 NA 0.38 6.34 0.33 7.67e-10 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC trans rs7395662 1.000 rs7938880 chr11:48642154 T/C cg21153622 chr11:89784906 NA -0.48 -7.76 -0.39 1.07e-13 HDL cholesterol; CRC cis rs2859741 0.967 rs494157 chr1:37512995 C/T cg09363841 chr1:37513479 NA 0.64 12.44 0.57 2.16e-29 Forced expiratory volume in 1 second (environmental tobacco smoke interaction); CRC cis rs10089 1.000 rs10478798 chr5:127442394 C/T cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.72 9.97 0.48 1.21e-20 Ileal carcinoids; CRC cis rs3018066 0.867 rs60538413 chr4:106952235 G/A cg01869342 chr4:106983673 TBCK 0.42 6.37 0.33 6.34e-10 Cancer; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg22608999 chr17:46184744 SNX11 0.47 6.54 0.34 2.41e-10 Response to antipsychotic treatment; CRC cis rs7224737 1.000 rs9889618 chr17:40293467 C/T cg20291162 chr17:40259547 DHX58 -0.55 -8.01 -0.4 2.06e-14 Fibrinogen levels; CRC cis rs4332037 0.722 rs60346318 chr7:1915824 C/G cg25834613 chr7:1915315 MAD1L1 -0.5 -7.85 -0.4 6.08e-14 Bipolar disorder; CRC cis rs7258465 1.000 rs34171762 chr19:18559410 G/A cg06953865 chr19:18549723 ISYNA1 -0.38 -5.79 -0.3 1.68e-8 Breast cancer; CRC cis rs476633 0.573 rs6492995 chr15:41529712 T/C cg18705301 chr15:41695430 NDUFAF1 -0.53 -8.66 -0.43 2.17e-16 Glomerular filtration rate (creatinine); CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg16211055 chr1:228594250 TRIM11 0.46 5.96 0.31 6.44e-9 Thyroid stimulating hormone; CRC cis rs7296418 0.961 rs7957096 chr12:123544878 A/G cg13010344 chr12:123464640 ARL6IP4 -0.36 -6.26 -0.33 1.19e-9 Platelet count; CRC cis rs798554 0.959 rs798557 chr7:2758982 G/A cg17321639 chr7:2759063 NA -0.52 -7.03 -0.36 1.18e-11 Height; CRC cis rs2070488 0.804 rs6764551 chr3:38460305 A/G cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.74 12.78 0.58 1.25e-30 Electrocardiographic conduction measures; CRC cis rs6867032 1.000 rs2129472 chr5:2016247 G/A cg26168224 chr5:2018326 NA 1.0 18.55 0.71 4.56e-53 Gut microbiome composition (winter); CRC cis rs11191270 0.554 rs10444022 chr10:104084889 A/G cg15320455 chr10:103880129 LDB1 0.75 6.99 0.36 1.57e-11 Intelligence (multi-trait analysis); CRC cis rs11212617 0.967 rs6589017 chr11:108308504 A/G cg12106634 chr11:108092400 ATM;NPAT 0.4 5.83 0.31 1.33e-8 Response to metformin in type 2 diabetes (glycemic); CRC cis rs2739330 0.627 rs9608219 chr22:24274119 G/C cg15242686 chr22:24348715 GSTTP1 0.46 7.03 0.36 1.18e-11 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs72945132 0.882 rs947781 chr11:70212755 G/A cg00319359 chr11:70116639 PPFIA1 0.57 6.39 0.33 5.8e-10 Coronary artery disease; CRC cis rs9389248 0.690 rs2072826 chr6:135253558 G/C cg22676075 chr6:135203613 NA -0.65 -10.08 -0.49 5.16e-21 High light scatter reticulocyte percentage of red cells; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg06649899 chr16:67261154 TMEM208;LRRC29 0.41 6.08 0.32 3.3e-9 Intelligence (multi-trait analysis); CRC cis rs12286929 0.898 rs117569901 chr11:115018509 T/G cg04055981 chr11:115044050 NA 0.39 6.33 0.33 7.96e-10 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs6456156 0.806 rs11967165 chr6:167529936 T/C cg05540913 chr6:167530185 CCR6 -0.42 -7.54 -0.38 4.71e-13 Primary biliary cholangitis; CRC trans rs11250097 0.549 rs11778177 chr8:11310362 C/T cg06636001 chr8:8085503 FLJ10661 -0.47 -6.65 -0.34 1.25e-10 Neuroticism; CRC cis rs9467773 1.000 rs4871 chr6:26545632 G/A cg09904177 chr6:26538194 HMGN4 0.85 14.88 0.63 1.17e-38 Intelligence (multi-trait analysis); CRC cis rs4363385 0.934 rs4240865 chr1:152954839 G/T cg25856811 chr1:152973957 SPRR3 0.22 5.81 0.31 1.44e-8 Inflammatory skin disease; CRC cis rs9905704 0.801 rs302847 chr17:56687481 C/T cg12560992 chr17:57184187 TRIM37 0.57 8.31 0.42 2.59e-15 Testicular germ cell tumor; CRC cis rs875971 0.965 rs9969301 chr7:65781655 G/A cg18876405 chr7:65276391 NA -0.53 -9.13 -0.45 6.95e-18 Aortic root size; CRC cis rs1401999 0.898 rs4148561 chr3:183726379 A/G cg01324343 chr3:183735012 ABCC5 0.79 14.33 0.62 1.63e-36 Anterior chamber depth; CRC cis rs4972806 0.739 rs10834 chr2:177042087 A/G cg14324370 chr2:177042789 NA 0.69 10.1 0.49 4.57e-21 IgG glycosylation; CRC cis rs1577917 1.000 rs10455455 chr6:86670214 G/A cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.56 -6.99 -0.36 1.51e-11 Response to antipsychotic treatment; CRC cis rs9916302 0.904 rs7216086 chr17:37709422 G/A cg07936489 chr17:37558343 FBXL20 -0.81 -12.31 -0.56 6.7200000000000006e-29 Glomerular filtration rate (creatinine); CRC cis rs7726839 0.540 rs72703087 chr5:598029 C/T cg16447950 chr5:562315 NA -0.74 -9.79 -0.47 4.96e-20 Obesity-related traits; CRC cis rs17401966 0.838 rs12132134 chr1:10378428 A/G cg19773385 chr1:10388646 KIF1B -0.61 -9.35 -0.46 1.35e-18 Hepatocellular carcinoma; CRC cis rs13108904 0.935 rs3755920 chr4:1243617 T/C cg19318889 chr4:1322082 MAEA 0.47 7.09 0.36 8.35e-12 Obesity-related traits; CRC cis rs4964805 0.626 rs11111767 chr12:104176246 A/G cg02344784 chr12:104178138 NT5DC3 -0.52 -7.78 -0.39 9.16e-14 Attention deficit hyperactivity disorder; CRC cis rs4713118 0.786 rs200502 chr6:27788062 C/T cg02683197 chr6:28174875 NA 0.64 7.86 0.4 5.59e-14 Parkinson's disease; CRC trans rs2243480 1.000 rs34933526 chr7:65383199 A/G cg10756647 chr7:56101905 PSPH 0.73 8.07 0.41 1.36e-14 Diabetic kidney disease; CRC cis rs9309473 0.687 rs6546827 chr2:73606493 C/T cg20560298 chr2:73613845 ALMS1 -0.53 -7.27 -0.37 2.69e-12 Metabolite levels; CRC cis rs6089584 0.507 rs28545731 chr20:60634102 C/T cg23463467 chr20:60627584 TAF4 0.44 8.15 0.41 7.92e-15 Body mass index; CRC cis rs801193 1.000 rs7785213 chr7:66138978 A/C cg25985355 chr7:65971099 NA 0.33 5.74 0.3 2.15e-8 Aortic root size; CRC cis rs2067615 0.524 rs4964187 chr12:107080313 C/A cg13491945 chr12:107078410 RFX4 0.36 6.2 0.32 1.67e-9 Heart rate; CRC cis rs6951245 1.000 rs113575110 chr7:1084394 G/A cg26224354 chr7:1096374 C7orf50;GPR146 -0.89 -11.23 -0.53 5.33e-25 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs6951245 0.872 rs75280240 chr7:1058511 C/T cg20603222 chr7:1096387 C7orf50;GPR146 -0.64 -7.55 -0.38 4.32e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg14211646 chr1:26758996 DHDDS 0.49 6.3 0.33 9.37e-10 Thyroid stimulating hormone; CRC trans rs8073060 0.586 rs72829927 chr17:34049992 A/G cg19694781 chr19:47549865 TMEM160 1.08 14.73 0.63 4.38e-38 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; CRC cis rs116095464 0.558 rs9312979 chr5:222057 A/C cg22496380 chr5:211416 CCDC127 -0.95 -9.42 -0.46 8.46e-19 Breast cancer; CRC cis rs9901225 1 rs9901225 chr17:40755811 C/T cg14558262 chr17:40713999 COASY 0.54 8.48 0.42 7.8e-16 Colorectal or endometrial cancer; CRC cis rs10208940 0.920 rs11894861 chr2:68706723 C/G cg12452813 chr2:68675892 NA 0.52 6.39 0.33 5.53e-10 Urate levels in lean individuals; CRC cis rs9611519 1.000 rs3818003 chr22:41609690 C/T cg03806693 chr22:41940476 POLR3H -0.45 -5.91 -0.31 8.38e-9 Neuroticism; CRC cis rs6952808 0.929 rs2280548 chr7:1976667 G/T cg04267008 chr7:1944627 MAD1L1 -0.76 -10.46 -0.5 2.69e-22 Bipolar disorder and schizophrenia; CRC cis rs1568889 0.774 rs11030235 chr11:28212375 A/G cg06544937 chr11:28130018 METT5D1;KIF18A 0.9 15.17 0.64 8.74e-40 Bipolar disorder; CRC cis rs1728785 0.792 rs1111502 chr16:68581209 A/G cg02972257 chr16:68554789 NA -0.58 -7.25 -0.37 3.09e-12 Ulcerative colitis; CRC cis rs2836974 0.666 rs4818015 chr21:40675493 A/C cg11890956 chr21:40555474 PSMG1 0.88 15.0 0.64 3.98e-39 Cognitive function; CRC cis rs9814567 0.679 rs1880379 chr3:134330612 C/T cg06109529 chr3:134205091 CEP63;ANAPC13 -0.67 -9.58 -0.47 2.53e-19 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs28386778 0.863 rs1376110 chr17:61779927 A/C cg11494091 chr17:61959527 GH2 0.66 10.96 0.52 4.85e-24 Prudent dietary pattern; CRC cis rs1883415 0.552 rs2328824 chr6:24507761 G/A cg20631270 chr6:24437470 GPLD1 -0.39 -6.0 -0.31 5.3e-9 Liver enzyme levels (alkaline phosphatase); CRC cis rs12155623 0.504 rs10808736 chr8:49873039 C/A cg22283653 chr8:49824208 NA 0.36 6.03 0.32 4.52e-9 Sudden cardiac arrest; CRC cis rs2243480 1.000 rs36068983 chr7:65408991 C/T cg18252515 chr7:66147081 NA -1.06 -12.44 -0.57 2.13e-29 Diabetic kidney disease; CRC cis rs9807989 0.507 rs2310300 chr2:103049074 A/G cg03938978 chr2:103052716 IL18RAP 0.59 10.1 0.49 4.69e-21 Asthma; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg08191566 chr7:64254770 ZNF138 0.37 6.18 0.32 1.92e-9 Liver disease severity in Alagille syndrome; CRC cis rs7044106 0.791 rs4837792 chr9:123483559 G/A cg09586646 chr9:123605570 PSMD5;LOC253039 0.63 9.3 0.46 2.01e-18 Hip circumference adjusted for BMI; CRC cis rs9398803 0.931 rs9375435 chr6:126661858 C/T cg19875578 chr6:126661172 C6orf173 0.4 5.63 0.3 3.9e-8 Male-pattern baldness; CRC cis rs13191362 0.507 rs2023037 chr6:163120385 C/T cg06582575 chr6:163149167 PACRG;PARK2 0.52 8.04 0.41 1.67e-14 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs7666738 0.830 rs35939134 chr4:98980311 A/G cg05340658 chr4:99064831 C4orf37 0.6 9.41 0.46 8.57e-19 Colonoscopy-negative controls vs population controls; CRC cis rs9814567 1.000 rs7630874 chr3:134293291 T/C cg06109529 chr3:134205091 CEP63;ANAPC13 0.83 12.18 0.56 1.98e-28 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC trans rs951252 0.504 rs11734405 chr4:146081096 C/T cg00832928 chr3:150329458 SELT -0.46 -5.96 -0.31 6.43e-9 Hip circumference; CRC cis rs2120019 0.935 rs8043181 chr15:75380424 T/C cg17294928 chr15:75287854 SCAMP5 -0.72 -10.61 -0.5 8.28e-23 Blood trace element (Zn levels); CRC cis rs34172651 0.571 rs9922156 chr16:24704329 C/A cg02428538 chr16:24856791 SLC5A11 0.58 7.13 0.37 6.38e-12 Intelligence (multi-trait analysis); CRC cis rs7726839 0.561 rs11955068 chr5:582324 C/T cg09021430 chr5:549028 NA -0.86 -10.93 -0.52 6.06e-24 Obesity-related traits; CRC cis rs35110281 0.714 rs2282526 chr21:45080552 A/T cg04455712 chr21:45112962 RRP1B 0.41 8.0 0.4 2.08e-14 Mean corpuscular volume; CRC cis rs6499255 1.000 rs55863174 chr16:69819996 G/C cg15192750 chr16:69999425 NA 0.57 7.39 0.38 1.19e-12 IgE levels; CRC cis rs2980439 0.870 rs2945230 chr8:8109936 A/G cg06636001 chr8:8085503 FLJ10661 0.61 9.52 0.46 3.95e-19 Neuroticism; CRC cis rs4664304 0.966 rs7601374 chr2:160754050 T/C cg03641300 chr2:160917029 PLA2R1 -0.4 -5.7 -0.3 2.69e-8 Crohn's disease;Inflammatory bowel disease; CRC trans rs11992162 0.967 rs10108320 chr8:11832263 A/T cg06636001 chr8:8085503 FLJ10661 -0.44 -6.45 -0.34 3.91e-10 Monocyte count; CRC cis rs2303745 0.589 rs6512179 chr19:17399105 T/C cg04248312 chr19:17393744 ANKLE1 -0.97 -14.52 -0.62 2.89e-37 Systemic lupus erythematosus; CRC cis rs9908102 0.740 rs60875833 chr17:12912789 T/G cg26162695 chr17:12921313 ELAC2 0.43 5.85 0.31 1.17e-8 Schizophrenia; CRC cis rs7666738 0.830 rs10010223 chr4:99021758 G/A cg05340658 chr4:99064831 C4orf37 0.61 9.51 0.46 4.05e-19 Colonoscopy-negative controls vs population controls; CRC cis rs17023223 0.537 rs61806983 chr1:119731524 G/C cg05756136 chr1:119680316 WARS2 -0.52 -7.13 -0.37 6.21e-12 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for BMI in active individuals; CRC cis rs7845219 0.544 rs4735330 chr8:95917770 A/C cg16049864 chr8:95962084 TP53INP1 -0.44 -6.69 -0.35 9.62e-11 Type 2 diabetes; CRC trans rs12699921 0.632 rs2691594 chr7:17864816 C/G cg15753394 chr6:17282781 RBM24 -0.36 -6.01 -0.31 5.03e-9 Fibrinogen levels; CRC cis rs7213347 0.780 rs7209564 chr17:2168233 C/T cg15816464 chr17:2026533 SMG6 0.38 6.4 0.33 5.22e-10 Total body bone mineral density; CRC cis rs11098699 0.821 rs11734868 chr4:124211544 A/G cg09941581 chr4:124220074 SPATA5 0.4 5.73 0.3 2.23e-8 Mosquito bite size; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg21413251 chr9:71320693 PIP5K1B 0.42 6.07 0.32 3.45e-9 Intelligence (multi-trait analysis); CRC cis rs7918232 0.662 rs10764662 chr10:27300643 T/A cg14442939 chr10:27389572 ANKRD26 0.65 7.08 0.36 8.52e-12 Breast cancer; CRC cis rs4713118 0.614 rs9380007 chr6:27660508 T/C cg15845792 chr6:28175446 NA 0.51 7.22 0.37 3.68e-12 Parkinson's disease; CRC cis rs3857067 1.000 rs1509940 chr4:95018758 C/T cg11021082 chr4:95130006 SMARCAD1 -0.4 -6.06 -0.32 3.63e-9 QT interval; CRC cis rs12135062 0.538 rs2651929 chr1:3101353 C/T cg21609526 chr1:3105151 PRDM16 0.34 5.7 0.3 2.71e-8 Migraine; CRC cis rs4148883 0.629 rs2602899 chr4:100010128 C/T cg12011299 chr4:100065546 ADH4 0.53 11.51 0.54 5.44e-26 Alcohol dependence; CRC cis rs34779708 0.966 rs998658 chr10:35408654 A/G cg03585969 chr10:35415529 CREM 0.59 7.97 0.4 2.56e-14 Inflammatory bowel disease;Crohn's disease; CRC cis rs875971 1.000 rs6970030 chr7:65968679 T/C cg18876405 chr7:65276391 NA 0.51 8.78 0.44 9.39e-17 Aortic root size; CRC cis rs10078 0.571 rs2721028 chr5:443849 A/G cg24955955 chr5:415729 AHRR 0.71 6.77 0.35 5.87e-11 Fat distribution (HIV); CRC cis rs13108904 0.901 rs7668661 chr4:1300172 A/G cg19318889 chr4:1322082 MAEA 0.41 6.3 0.33 9.63e-10 Obesity-related traits; CRC cis rs875971 0.545 rs66594357 chr7:65792784 G/A cg18876405 chr7:65276391 NA 0.45 6.38 0.33 6.09e-10 Aortic root size; CRC cis rs8072100 0.967 rs8072644 chr17:45653364 A/T cg25173405 chr17:45401733 C17orf57 0.42 6.61 0.34 1.59e-10 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs10463316 0.894 rs10062856 chr5:150768196 C/G cg03212797 chr5:150827313 SLC36A1 -0.49 -7.74 -0.39 1.26e-13 Metabolite levels (Pyroglutamine); CRC cis rs28386778 0.897 rs4968598 chr17:61835579 T/C cg22520471 chr17:61851767 DDX42;CCDC47 0.74 11.6 0.54 2.6e-26 Prudent dietary pattern; CRC cis rs6460942 0.841 rs62448597 chr7:12449110 G/C cg20607287 chr7:12443886 VWDE -0.68 -7.35 -0.38 1.59e-12 Coronary artery disease; CRC trans rs1814175 0.529 rs1988417 chr11:49932430 A/G cg03929089 chr4:120376271 NA -0.8 -11.56 -0.54 3.46e-26 Height; CRC cis rs13126513 0.519 rs959247 chr4:100556984 A/G cg05468953 chr4:100565104 NA 0.53 7.88 0.4 4.93e-14 Metabolite levels (MHPG); CRC cis rs7949030 0.626 rs11231154 chr11:62362293 A/G cg11742103 chr11:62369870 EML3;MTA2 0.62 11.71 0.54 1e-26 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; CRC cis rs1062746 1.000 rs1062746 chr16:87364650 A/G cg02258303 chr16:87377426 FBXO31 -0.57 -8.99 -0.44 1.95e-17 Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 2 peripheral neuropathy); CRC cis rs4713118 0.869 rs9283882 chr6:27715258 A/C cg15786705 chr6:28176104 NA 0.55 7.78 0.39 9.76e-14 Parkinson's disease; CRC cis rs875971 0.862 rs880166 chr7:65670762 T/C cg12463550 chr7:65579703 CRCP -0.53 -7.5 -0.38 6.05e-13 Aortic root size; CRC cis rs10503871 0.761 rs6997010 chr8:30365489 T/A cg26383811 chr8:30366931 RBPMS 0.49 8.12 0.41 9.78e-15 Metabolite levels (X-11787); CRC cis rs11190604 1.000 rs12355721 chr10:102244911 C/T cg16342193 chr10:102329863 NA -0.37 -6.01 -0.31 5.02e-9 Palmitoleic acid (16:1n-7) levels; CRC cis rs7208859 0.573 rs8078656 chr17:29080971 A/T cg01831904 chr17:28903510 LRRC37B2 -0.63 -6.49 -0.34 3.16e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs9916302 0.904 rs4794807 chr17:37531718 T/A cg15445000 chr17:37608096 MED1 -0.42 -9.13 -0.45 7.24e-18 Glomerular filtration rate (creatinine); CRC cis rs9611565 0.729 rs203320 chr22:41913477 T/C cg03806693 chr22:41940476 POLR3H -0.72 -10.24 -0.49 1.52e-21 Vitiligo; CRC cis rs4332037 0.575 rs55952733 chr7:2070680 G/A cg02825527 chr7:2087843 MAD1L1 -0.46 -5.62 -0.3 4.15e-8 Bipolar disorder; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg27351675 chr17:16284307 UBB 0.41 6.31 0.33 9.04e-10 Liver disease severity in Alagille syndrome; CRC cis rs16937 0.662 rs10900464 chr1:205157100 T/C cg00857998 chr1:205179979 DSTYK 0.41 5.65 0.3 3.49e-8 Schizophrenia; CRC cis rs9287719 0.967 rs6721514 chr2:10751062 T/C cg00105475 chr2:10696890 NA 0.45 7.09 0.36 8.03e-12 Prostate cancer; CRC cis rs6691722 0.503 rs6692646 chr1:24707629 C/T cg18323236 chr1:24743029 NIPAL3 0.39 5.68 0.3 3.01e-8 Response to interferon beta in multiple sclerosis; CRC cis rs9649213 0.593 rs6465673 chr7:97968887 C/T cg24562669 chr7:97807699 LMTK2 0.43 7.15 0.37 5.66e-12 Prostate cancer (SNP x SNP interaction); CRC cis rs7647973 0.667 rs9869256 chr3:49624095 T/G cg13072238 chr3:49761600 GMPPB -0.57 -5.81 -0.31 1.46e-8 Menarche (age at onset); CRC cis rs597539 0.652 rs514833 chr11:68657734 C/T cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.9 15.68 0.65 8.67e-42 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs9488822 0.596 rs13206506 chr6:116324460 A/G cg05304507 chr6:116381966 FRK 0.31 7.98 0.4 2.38e-14 Cholesterol, total;LDL cholesterol; CRC cis rs853679 0.517 rs9366715 chr6:28064633 A/G cg23161317 chr6:28129485 ZNF389 0.52 6.38 0.33 6.1e-10 Depression; CRC cis rs270601 0.739 rs1979981 chr5:131601720 G/A cg22638593 chr5:131593259 PDLIM4 0.49 9.08 0.45 1.05e-17 Acylcarnitine levels; CRC cis rs4523957 0.620 rs1565764 chr17:2074303 G/A cg16513277 chr17:2031491 SMG6 -0.64 -10.79 -0.51 1.94e-23 Autism spectrum disorder or schizophrenia;Schizophrenia; CRC trans rs12599106 0.839 rs3853177 chr16:34498532 A/G cg03395511 chr6:291903 DUSP22 -0.5 -6.83 -0.35 4.18e-11 Menopause (age at onset); CRC cis rs1707322 1.000 rs1707322 chr1:46505147 C/T cg06784218 chr1:46089804 CCDC17 0.55 9.78 0.47 5.37e-20 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs55823223 0.590 rs11870142 chr17:73859002 A/G cg10935138 chr17:73851978 WBP2 0.56 6.98 0.36 1.59e-11 Psoriasis; CRC cis rs736408 0.570 rs11130327 chr3:52793239 A/G cg08222913 chr3:52553049 STAB1 -0.34 -6.15 -0.32 2.24e-9 Bipolar disorder; CRC cis rs329648 1.000 rs329652 chr11:133769699 A/G cg15485101 chr11:133734466 NA 0.36 5.78 0.3 1.77e-8 Parkinson's disease; CRC cis rs10504229 1.000 rs66495524 chr8:58187365 C/T cg22535103 chr8:58192502 C8orf71 -0.82 -12.27 -0.56 9.63e-29 Developmental language disorder (linguistic errors); CRC cis rs6662572 0.851 rs55654017 chr1:46249299 T/G cg03123370 chr1:45965343 CCDC163P;MMACHC 0.45 5.64 0.3 3.71e-8 Blood protein levels; CRC cis rs2179367 0.959 rs652807 chr6:149737495 A/G cg16235748 chr6:149772707 ZC3H12D 0.34 5.79 0.3 1.62e-8 Dupuytren's disease; CRC cis rs7613875 0.654 rs3774751 chr3:50209053 G/T cg24110177 chr3:50126178 RBM5 0.38 5.71 0.3 2.56e-8 Body mass index; CRC cis rs3617 0.625 rs11719137 chr3:52876389 G/T cg11645453 chr3:52864694 ITIH4 -0.46 -9.32 -0.46 1.79e-18 Red blood cell count;Autism spectrum disorder or schizophrenia; CRC cis rs2073499 0.872 rs77097132 chr3:50301050 C/T cg09545109 chr3:50388910 TUSC4;CYB561D2 0.64 5.65 0.3 3.5e-8 Schizophrenia; CRC cis rs2120019 0.938 rs5020842 chr15:75322310 T/C cg11632617 chr15:75315747 PPCDC -0.56 -7.73 -0.39 1.29e-13 Blood trace element (Zn levels); CRC trans rs1005277 0.522 rs9417256 chr10:37976990 A/G cg23533926 chr12:111358616 MYL2 -0.43 -6.28 -0.33 1.05e-9 Extrinsic epigenetic age acceleration; CRC cis rs2535633 0.631 rs2710346 chr3:52974152 C/T cg15147215 chr3:52552868 STAB1 0.43 6.92 0.36 2.38e-11 Body mass index; CRC cis rs6988636 1.000 rs57322232 chr8:124193532 A/G cg27053337 chr8:124217698 FAM83A 0.42 6.36 0.33 6.62e-10 Urinary uromodulin levels; CRC cis rs35849525 0.633 rs62263602 chr3:50152491 C/T cg05623727 chr3:50126028 RBM5 0.53 6.93 0.36 2.25e-11 Intelligence (multi-trait analysis); CRC trans rs2055729 0.645 rs6989793 chr8:9744650 A/G cg08975724 chr8:8085496 FLJ10661 -0.48 -6.03 -0.32 4.39e-9 Multiple myeloma (hyperdiploidy); CRC cis rs589448 0.538 rs683790 chr12:69751434 T/G cg19645103 chr12:69753606 YEATS4 -0.43 -5.62 -0.3 4.09e-8 Cerebrospinal fluid biomarker levels; CRC cis rs13064411 0.627 rs28710051 chr3:113143531 G/A cg10517650 chr3:113235015 CCDC52 -0.36 -5.92 -0.31 8.19e-9 Response to simvastatin treatment (PCSK9 protein level change); CRC cis rs270601 0.690 rs162907 chr5:131580152 A/G cg12564285 chr5:131593104 PDLIM4 -0.57 -10.33 -0.5 7.3e-22 Acylcarnitine levels; CRC cis rs7659604 0.676 rs7691955 chr4:122700462 A/T cg06713675 chr4:122721982 EXOSC9 -0.51 -8.34 -0.42 1.99e-15 Type 2 diabetes; CRC cis rs1448094 0.511 rs61930588 chr12:86158991 A/G cg02569458 chr12:86230093 RASSF9 0.47 7.83 0.4 6.55e-14 Major depressive disorder; CRC cis rs72634258 0.842 rs7545677 chr1:8165619 C/T cg00042356 chr1:8021962 PARK7 0.55 6.27 0.33 1.15e-9 Inflammatory bowel disease; CRC cis rs6502050 0.777 rs6502058 chr17:80082500 A/C cg11859384 chr17:80120422 CCDC57 0.37 5.82 0.31 1.36e-8 Life satisfaction; CRC cis rs478304 0.619 rs10896028 chr11:65432187 A/T cg05805236 chr11:65401703 PCNXL3 -0.41 -6.61 -0.34 1.6e-10 Acne (severe); CRC cis rs2075371 0.897 rs1646733 chr7:134002228 C/A cg20476274 chr7:133979776 SLC35B4 0.73 12.46 0.57 1.81e-29 Mean platelet volume; CRC cis rs4268898 0.662 rs12052954 chr2:24425620 C/T cg06627628 chr2:24431161 ITSN2 0.8 11.21 0.53 6.66e-25 Asthma; CRC cis rs12190007 0.547 rs3006178 chr6:169823936 G/A cg15038512 chr6:170123185 PHF10 -0.38 -5.93 -0.31 7.8e-9 Obesity-related traits; CRC cis rs1670533 1.000 rs13107058 chr4:1054379 G/A cg27284194 chr4:1044797 NA 0.5 6.2 0.32 1.66e-9 Recombination rate (females); CRC cis rs1008375 0.966 rs28441502 chr4:17598384 G/A cg16339924 chr4:17578868 LAP3 0.6 8.06 0.41 1.42e-14 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs896854 0.936 rs10108430 chr8:95961794 C/T cg16049864 chr8:95962084 TP53INP1 -0.65 -11.9 -0.55 2.05e-27 Type 2 diabetes; CRC trans rs7395662 0.517 rs2021248 chr11:49013054 C/T cg03929089 chr4:120376271 NA -0.48 -6.82 -0.35 4.29e-11 HDL cholesterol; CRC trans rs11225569 0.539 rs11225822 chr11:103345030 A/C cg01615333 chr12:127765195 NA -0.62 -6.02 -0.31 4.68e-9 Diisocyanate-induced asthma; CRC cis rs12476592 0.602 rs262505 chr2:63861786 C/T cg10828910 chr2:63850056 LOC388955 0.47 5.65 0.3 3.48e-8 Childhood ear infection; CRC cis rs12745968 0.569 rs7521752 chr1:93017141 C/T cg17283838 chr1:93427260 FAM69A -0.46 -6.16 -0.32 2.13e-9 Bipolar disorder and schizophrenia; CRC cis rs6502050 0.835 rs28481866 chr17:80105160 G/A cg13198984 chr17:80129470 CCDC57 0.46 8.16 0.41 6.94e-15 Life satisfaction; CRC cis rs11864453 0.749 rs7192730 chr16:72124219 T/C cg23815491 chr16:72088622 HP 0.5 7.6 0.39 3.09e-13 Fibrinogen levels; CRC cis rs9527 0.615 rs9733635 chr10:104711940 G/A cg04362960 chr10:104952993 NT5C2 0.59 8.46 0.42 9.09e-16 Arsenic metabolism; CRC cis rs908922 0.651 rs4240886 chr1:152530396 A/T cg09873164 chr1:152488093 CRCT1 -0.35 -6.01 -0.31 4.93e-9 Hair morphology; CRC trans rs6733379 0.588 rs2193790 chr2:34445953 A/G cg26462239 chr17:45608823 NPEPPS -0.44 -6.28 -0.33 1.08e-9 Attention deficit hyperactivity disorder and conduct disorder; CRC cis rs6502050 0.835 rs7222057 chr17:80087647 C/A cg19223190 chr17:80058835 NA 0.39 6.09 0.32 3.08e-9 Life satisfaction; CRC cis rs6951245 0.554 rs2070118 chr7:1132505 G/A cg04025307 chr7:1156635 C7orf50 0.7 8.84 0.44 5.72e-17 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs17532515 0.628 rs12502572 chr4:141485134 C/T cg09181644 chr4:141490428 UCP1 0.32 5.72 0.3 2.4e-8 Select biomarker traits; CRC cis rs4319547 0.737 rs10773176 chr12:122944713 A/G cg05707623 chr12:122985044 ZCCHC8 -0.54 -7.15 -0.37 5.79e-12 Body mass index; CRC trans rs4650994 0.935 rs2811289 chr1:178572693 G/A cg05059571 chr16:84539110 KIAA1609 0.47 7.1 0.36 7.73e-12 HDL cholesterol levels;HDL cholesterol; CRC cis rs2439831 0.867 rs2447211 chr15:43936351 G/A cg02155558 chr15:43621948 ADAL;LCMT2 0.67 7.57 0.38 3.88e-13 Lung cancer in ever smokers; CRC cis rs556990 0.760 rs3024739 chr13:113819948 G/A cg18105134 chr13:113819100 PROZ -0.85 -11.99 -0.55 1.03e-27 Blood protein levels; CRC cis rs6062302 0.522 rs914558 chr20:62216976 A/G cg09650180 chr20:62225654 GMEB2 -0.51 -6.83 -0.35 4.15e-11 Glioblastoma; CRC cis rs11148252 0.740 rs9526914 chr13:52976300 G/T cg00495681 chr13:53174319 NA 0.54 7.88 0.4 4.89e-14 Lewy body disease; CRC cis rs600626 0.636 rs10899109 chr11:75451201 G/A cg24262691 chr11:75473276 NA 0.55 7.56 0.38 4.02e-13 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CRC cis rs6424115 1.000 rs2256179 chr1:24132305 A/G cg15997130 chr1:24165203 NA -0.73 -11.7 -0.54 1.09e-26 Immature fraction of reticulocytes; CRC cis rs12135062 0.687 rs6685614 chr1:3108517 C/T cg00254258 chr1:3105189 PRDM16 0.42 7.37 0.38 1.36e-12 Migraine; CRC cis rs7086627 0.515 rs10887903 chr10:82210641 C/T cg09626299 chr10:82213104 TSPAN14 -0.38 -6.51 -0.34 2.76e-10 Post bronchodilator FEV1; CRC cis rs853679 0.546 rs175597 chr6:27810626 T/C cg23259851 chr6:27775964 HIST1H2AI;HIST1H2BL 0.71 5.97 0.31 5.98e-9 Depression; CRC cis rs9660180 0.967 rs11260623 chr1:1781456 G/T cg05132306 chr1:1846340 CALML6 -0.51 -7.88 -0.4 4.7e-14 Body mass index; CRC trans rs1814175 0.645 rs28634872 chr11:50042175 T/A cg03929089 chr4:120376271 NA -0.89 -16.04 -0.66 3.41e-43 Height; CRC cis rs798554 0.683 rs1636264 chr7:2864586 G/T cg17321639 chr7:2759063 NA -0.42 -5.91 -0.31 8.33e-9 Height; CRC cis rs3793683 0.928 rs10781585 chr10:134553369 C/A cg27286337 chr10:134555280 INPP5A -0.88 -17.02 -0.68 4.93e-47 Migraine; CRC trans rs1005277 0.522 rs1208767 chr10:38042295 G/T cg23533926 chr12:111358616 MYL2 -0.44 -6.45 -0.34 3.99e-10 Extrinsic epigenetic age acceleration; CRC cis rs10504229 1.000 rs67705655 chr8:58177688 G/A cg24829409 chr8:58192753 C8orf71 -0.68 -11.34 -0.53 2.27e-25 Developmental language disorder (linguistic errors); CRC trans rs1814175 0.817 rs11493756 chr11:50017885 T/C cg11707556 chr5:10655725 ANKRD33B -0.42 -8.03 -0.4 1.75e-14 Height; CRC cis rs73206853 0.764 rs7314552 chr12:110618890 C/T cg12870014 chr12:110450643 ANKRD13A 0.82 10.2 0.49 2.1e-21 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC cis rs11203032 0.831 rs10887932 chr10:90966996 C/G cg16672925 chr10:90967113 CH25H 0.46 6.13 0.32 2.45e-9 Heart failure; CRC cis rs6912958 1.000 rs6454630 chr6:88171357 C/G cg12350822 chr6:88032061 C6orf162;GJB7 0.31 6.02 0.32 4.61e-9 Monocyte percentage of white cells; CRC trans rs1814175 0.645 rs847632 chr11:49926097 C/T cg03929089 chr4:120376271 NA -0.9 -15.65 -0.65 1.22e-41 Height; CRC cis rs713477 0.654 rs11158040 chr14:55914607 T/C cg13175173 chr14:55914753 NA -0.43 -7.78 -0.39 9.59e-14 Pediatric bone mineral content (femoral neck); CRC cis rs155076 0.938 rs9509630 chr13:21844314 G/A cg25811766 chr13:21894605 NA -0.57 -6.0 -0.31 5.12e-9 White matter hyperintensity burden; CRC cis rs12220238 1.000 rs6480723 chr10:75966366 A/G cg19889307 chr10:75911429 ADK;AP3M1 0.54 5.61 0.3 4.26e-8 Soluble interleukin-2 receptor subunit alpha; CRC cis rs769267 0.930 rs747050 chr19:19584987 C/G cg01262667 chr19:19385393 TM6SF2 0.36 5.84 0.31 1.25e-8 Tonsillectomy; CRC cis rs13191362 0.507 rs2023036 chr6:163122736 C/T cg06582575 chr6:163149167 PACRG;PARK2 0.56 8.5 0.42 6.76e-16 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs4588572 0.643 rs1159929 chr5:77768820 A/G cg11547950 chr5:77652471 NA 0.51 6.9 0.36 2.66e-11 Triglycerides; CRC cis rs898097 0.625 rs898095 chr17:80890638 T/C cg15664640 chr17:80829946 TBCD 0.47 7.83 0.4 6.76e-14 Breast cancer; CRC cis rs9303401 0.659 rs7224276 chr17:56897827 C/T cg10487724 chr17:56770010 TEX14;RAD51C 0.76 9.59 0.47 2.2e-19 Cognitive test performance; CRC cis rs8077889 0.703 rs231531 chr17:41946180 A/C cg25876840 chr17:41920477 NA 0.47 6.36 0.33 6.78e-10 Triglycerides; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg07050772 chr17:48423262 XYLT2 0.38 6.0 0.31 5.31e-9 Liver disease severity in Alagille syndrome; CRC cis rs9733 0.596 rs1336898 chr1:150665050 G/A cg15448220 chr1:150897856 SETDB1 0.45 6.43 0.33 4.42e-10 Tonsillectomy; CRC cis rs2836974 0.897 rs8132419 chr21:40527827 C/T cg17971929 chr21:40555470 PSMG1 0.84 12.96 0.58 2.62e-31 Cognitive function; CRC cis rs12477438 0.798 rs6542848 chr2:99573732 T/C cg26064155 chr2:99771622 LIPT1;TSGA10 -0.75 -10.54 -0.5 1.39e-22 Chronic sinus infection; CRC cis rs10256972 0.567 rs2949185 chr7:1209013 A/G cg07308232 chr7:1071921 C7orf50 -0.45 -6.13 -0.32 2.54e-9 Longevity;Endometriosis; CRC cis rs875971 0.862 rs2901152 chr7:65765004 G/A cg00343986 chr7:65444356 GUSB -0.45 -6.27 -0.33 1.12e-9 Aortic root size; CRC cis rs6502050 0.731 rs34796376 chr17:80116635 G/T cg19223190 chr17:80058835 NA 0.39 6.31 0.33 9.07e-10 Life satisfaction; CRC cis rs9549367 0.789 rs9604040 chr13:113910611 A/G cg18105134 chr13:113819100 PROZ 0.76 11.76 0.54 7.03e-27 Platelet distribution width; CRC cis rs8060686 0.920 rs12448923 chr16:67839128 C/T cg19582491 chr16:67682965 RLTPR -0.58 -6.92 -0.36 2.32e-11 HDL cholesterol;Metabolic syndrome; CRC cis rs1005277 0.579 rs11011461 chr10:38431427 G/A cg00409905 chr10:38381863 ZNF37A -0.67 -11.18 -0.52 8.29e-25 Extrinsic epigenetic age acceleration; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg03053427 chr7:75649626 STYXL1 0.44 6.51 0.34 2.74e-10 Response to antipsychotic treatment; CRC cis rs2281845 0.929 rs6704363 chr1:201096383 A/G cg24849736 chr1:201084428 NA 0.64 11.68 0.54 1.33e-26 Permanent tooth development; CRC cis rs763121 0.925 rs9611008 chr22:39098787 T/C cg06544989 chr22:39130855 UNC84B 0.49 7.99 0.4 2.3e-14 Menopause (age at onset); CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg27581118 chr15:85780523 NA 0.37 6.26 0.33 1.21e-9 Myopia (pathological); CRC cis rs6502050 0.805 rs11077970 chr17:80085916 C/T cg25804541 chr17:80189381 SLC16A3 0.31 5.88 0.31 1.03e-8 Life satisfaction; CRC cis rs10493773 0.674 rs414618 chr1:86220418 G/A cg17807903 chr1:86174739 ZNHIT6 0.43 9.86 0.48 3.02e-20 Urate levels in overweight individuals; CRC cis rs73200209 0.744 rs7136498 chr12:116483993 T/G cg01776926 chr12:116560359 MED13L -0.64 -7.68 -0.39 1.78e-13 Total body bone mineral density; CRC cis rs3733346 0.529 rs6842493 chr4:914638 T/C cg23939001 chr4:940644 TMEM175 0.73 15.07 0.64 2.08e-39 Sjögren's syndrome; CRC cis rs798554 0.757 rs1713919 chr7:2864706 C/A cg04166393 chr7:2884313 GNA12 0.52 6.93 0.36 2.26e-11 Height; CRC cis rs6456156 0.742 rs1331299 chr6:167533467 A/G cg05540913 chr6:167530185 CCR6 0.42 7.79 0.39 8.94e-14 Primary biliary cholangitis; CRC cis rs7618915 0.571 rs2289249 chr3:52597664 G/A cg15147215 chr3:52552868 STAB1 -0.63 -10.56 -0.5 1.22e-22 Bipolar disorder; CRC trans rs2055729 0.710 rs13257396 chr8:9736383 A/C cg06636001 chr8:8085503 FLJ10661 0.57 6.94 0.36 2.03e-11 Multiple myeloma (hyperdiploidy); CRC trans rs925098 0.577 rs2724470 chr4:17996046 A/G cg24342377 chr7:97868109 TECPR1 0.41 6.13 0.32 2.46e-9 Birth weight;Height; CRC cis rs3736485 0.816 rs11632853 chr15:51855933 T/C cg08986416 chr15:51914746 DMXL2 -0.48 -6.97 -0.36 1.78e-11 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs28386778 0.830 rs2584625 chr17:61903445 G/C cg25654072 chr17:61904446 PSMC5;FTSJ3 0.74 11.51 0.54 5.33e-26 Prudent dietary pattern; CRC cis rs2274273 0.563 rs79163357 chr14:55738449 G/A cg10130446 chr14:55658398 DLGAP5 -0.43 -6.12 -0.32 2.67e-9 Protein biomarker; CRC cis rs769267 0.896 rs10410664 chr19:19556651 G/A cg02546618 chr19:19431379 KIAA0892;SF4 0.46 6.38 0.33 6.05e-10 Tonsillectomy; CRC cis rs10924970 0.601 rs12402448 chr1:235448095 A/T cg09010748 chr1:235293032 TOMM20 -0.42 -5.87 -0.31 1.04e-8 Asthma; CRC cis rs644799 1.000 rs586238 chr11:95560371 C/T cg03916912 chr11:95522834 CEP57;FAM76B 0.96 18.49 0.71 7.83e-53 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC trans rs1455244 0.700 rs7229302 chr18:11508904 G/T cg12691373 chr17:79670378 MRPL12 0.42 6.76 0.35 6.39e-11 Schizophrenia; CRC cis rs7727544 0.582 rs4361509 chr5:131536753 A/G cg02033258 chr5:131593261 PDLIM4 -0.33 -5.88 -0.31 9.91e-9 Blood metabolite levels; CRC cis rs8060686 0.920 rs16942887 chr16:67928042 G/A cg26727032 chr16:67993705 SLC12A4 -0.58 -7.09 -0.36 8.05e-12 HDL cholesterol;Metabolic syndrome; CRC cis rs911555 0.755 rs11627446 chr14:103946450 G/C cg12935359 chr14:103987150 CKB -0.55 -9.05 -0.45 1.24e-17 Intelligence (multi-trait analysis); CRC cis rs58799304 0.531 rs12035615 chr1:156055344 C/T cg15685922 chr1:156045208 MEX3A -0.46 -8.23 -0.41 4.5e-15 Ischemic stroke; CRC cis rs6952808 1.000 rs4256490 chr7:1890764 G/A cg20295408 chr7:1910781 MAD1L1 -0.43 -5.98 -0.31 5.97e-9 Bipolar disorder and schizophrenia; CRC cis rs2576037 0.583 rs8096263 chr18:44515216 C/T cg19077165 chr18:44547161 KATNAL2 -0.66 -11.13 -0.52 1.25e-24 Personality dimensions; CRC cis rs2797685 1.000 rs1689904 chr1:7890801 C/T cg04725166 chr1:7887271 PER3 -0.48 -6.06 -0.32 3.69e-9 Crohn's disease; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg09626274 chr15:77224230 RCN2 0.47 6.35 0.33 7.13e-10 Anxiety disorder; CRC trans rs11098499 0.954 rs12499324 chr4:120393786 C/T cg25214090 chr10:38739885 LOC399744 0.66 10.65 0.51 6.07e-23 Corneal astigmatism; CRC trans rs2727020 0.658 rs1851992 chr11:49438110 C/T cg15704280 chr7:45808275 SEPT13 -0.91 -17.24 -0.69 6.89e-48 Coronary artery disease; CRC cis rs1018836 0.847 rs4735226 chr8:91569238 T/A cg16814680 chr8:91681699 NA -0.74 -11.74 -0.54 8.38e-27 Ejection fraction in Tripanosoma cruzi seropositivity; CRC cis rs10924970 0.649 rs12029822 chr1:235381342 T/G cg09010748 chr1:235293032 TOMM20 -0.42 -5.75 -0.3 2.04e-8 Asthma; CRC cis rs6502050 0.871 rs6502056 chr17:80070912 C/G cg13198984 chr17:80129470 CCDC57 -0.45 -7.67 -0.39 1.93e-13 Life satisfaction; CRC cis rs6066835 1.000 rs6066831 chr20:47354131 C/A cg18078177 chr20:47281410 PREX1 0.63 5.78 0.3 1.7e-8 Multiple myeloma; CRC cis rs5769765 0.955 rs9616394 chr22:50314927 G/C cg02269571 chr22:50332266 NA -0.6 -7.96 -0.4 2.83e-14 Schizophrenia; CRC cis rs1538970 0.816 rs868351 chr1:46009818 G/T cg05343316 chr1:45956843 TESK2 0.73 9.94 0.48 1.6e-20 Platelet count; CRC cis rs9914988 0.943 rs4262997 chr17:27129562 A/G cg20469991 chr17:27169893 C17orf63 -0.6 -7.27 -0.37 2.59e-12 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs2576037 0.583 rs641366 chr18:44430326 C/T cg23996704 chr18:44553084 KATNAL2 -0.33 -6.85 -0.35 3.54e-11 Personality dimensions; CRC cis rs780096 0.506 rs1728922 chr2:27644464 A/C cg12648201 chr2:27665141 KRTCAP3 -0.29 -5.83 -0.31 1.3e-8 Total body bone mineral density; CRC cis rs972578 0.905 rs55682747 chr22:43361928 A/T cg01576275 chr22:43409880 NA -0.45 -7.27 -0.37 2.62e-12 Mean platelet volume; CRC cis rs908922 0.676 rs4240884 chr1:152529792 C/T cg09873164 chr1:152488093 CRCT1 -0.36 -6.13 -0.32 2.48e-9 Hair morphology; CRC cis rs11098499 1.000 rs11098499 chr4:120187611 C/T cg09307838 chr4:120376055 NA 0.63 9.63 0.47 1.72e-19 Corneal astigmatism; CRC cis rs2842992 0.724 rs2273827 chr6:160211339 C/A cg19482086 chr6:160211437 TCP1;MRPL18 0.84 13.56 0.6 1.38e-33 Age-related macular degeneration (geographic atrophy); CRC cis rs7134594 0.677 rs2075440 chr12:109859100 C/T cg19025524 chr12:109796872 NA 0.39 5.84 0.31 1.29e-8 HDL cholesterol; CRC cis rs1223397 0.651 rs488297 chr6:13300496 C/T cg20827128 chr6:13274284 PHACTR1 0.37 5.6 0.3 4.42e-8 Blood pressure; CRC cis rs7113874 0.569 rs4418812 chr11:8612000 A/G cg17679104 chr11:8615758 STK33 0.36 6.07 0.32 3.54e-9 Body mass index in physically active individuals;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs7085104 0.572 rs284860 chr10:104572963 T/C cg11453585 chr10:104263688 ACTR1A;SUFU 0.41 5.93 0.31 7.76e-9 Immature fraction of reticulocytes;Schizophrenia; CRC cis rs3820068 0.581 rs72645889 chr1:15930251 T/G cg27534772 chr1:16042836 PLEKHM2 0.54 10.46 0.5 2.7e-22 Systolic blood pressure; CRC cis rs7829975 0.572 rs28730413 chr8:8795447 A/C cg06636001 chr8:8085503 FLJ10661 -0.52 -7.59 -0.39 3.26e-13 Mood instability; CRC cis rs72634258 0.945 rs36016881 chr1:8051241 A/G cg26816564 chr1:7831052 VAMP3 0.55 6.17 0.32 1.97e-9 Inflammatory bowel disease; CRC cis rs992157 0.735 rs10932765 chr2:219099484 T/C cg00012203 chr2:219082015 ARPC2 0.62 10.18 0.49 2.46e-21 Colorectal cancer; CRC cis rs9322193 0.566 rs9397070 chr6:150243209 T/C cg13206674 chr6:150067644 NUP43 -0.45 -5.75 -0.3 2.06e-8 Lung cancer; CRC cis rs11650494 0.808 rs61286260 chr17:47433222 T/C cg08112188 chr17:47440006 ZNF652 0.9 9.07 0.45 1.09e-17 Prostate cancer; CRC cis rs2732480 0.517 rs2634676 chr12:48738236 A/G cg21466736 chr12:48725269 NA -0.59 -8.67 -0.43 2.02e-16 Hemoglobin concentration;Red blood cell count;Hematocrit; CRC cis rs6076065 0.723 rs4813495 chr20:23391617 A/G cg11657817 chr20:23433608 CST11 0.43 6.32 0.33 8.28e-10 Facial morphology (factor 15, philtrum width); CRC cis rs9322193 0.923 rs1934534 chr6:150033032 A/G cg13206674 chr6:150067644 NUP43 0.66 9.85 0.48 3.16e-20 Lung cancer; CRC trans rs7613875 0.580 rs6808044 chr3:50136165 A/G cg21665057 chr3:196295764 WDR53;FBXO45 -0.43 -6.22 -0.32 1.5e-9 Body mass index; CRC cis rs7089973 0.604 rs7923693 chr10:116619566 A/G cg23260525 chr10:116636907 FAM160B1 0.39 9.2 0.45 4.19e-18 Bipolar disorder or attention deficit hyperactivity disorder; CRC cis rs17065868 0.764 rs9533865 chr13:45037349 C/A cg10246903 chr13:45222710 NA 0.54 5.69 0.3 2.79e-8 Antineutrophil cytoplasmic antibody-associated vasculitis; CRC cis rs1707322 1.000 rs785490 chr1:46577124 T/C cg06784218 chr1:46089804 CCDC17 -0.61 -10.54 -0.5 1.37e-22 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs561341 0.739 rs8070554 chr17:30216868 A/T cg13647721 chr17:30228624 UTP6 -0.62 -7.47 -0.38 7.15e-13 Hip circumference adjusted for BMI; CRC cis rs3858526 0.959 rs11039540 chr11:5928334 C/T cg02574844 chr11:5959923 NA -0.43 -6.11 -0.32 2.77e-9 DNA methylation (variation); CRC cis rs8141529 0.732 rs5752798 chr22:29181868 A/G cg02153584 chr22:29168773 CCDC117 0.54 7.98 0.4 2.39e-14 Lymphocyte counts; CRC cis rs1670533 1.000 rs11735663 chr4:1051845 C/T cg27284194 chr4:1044797 NA 0.51 6.35 0.33 7.31e-10 Recombination rate (females); CRC cis rs3733585 0.563 rs881971 chr4:9930962 A/G cg00071950 chr4:10020882 SLC2A9 -0.54 -9.37 -0.46 1.2e-18 Cleft plate (environmental tobacco smoke interaction); CRC cis rs875971 0.571 rs78668714 chr7:65939451 G/A cg03233332 chr7:66118400 NA -0.41 -5.63 -0.3 3.93e-8 Aortic root size; CRC cis rs2576037 0.526 rs10853544 chr18:44474194 T/C cg23996704 chr18:44553084 KATNAL2 -0.35 -7.07 -0.36 9.44e-12 Personality dimensions; CRC cis rs11628318 0.614 rs11847932 chr14:103185435 T/G cg12046867 chr14:103022105 NA 0.75 8.81 0.44 7.1e-17 Platelet count; CRC cis rs4474465 0.688 rs10899553 chr11:78265210 A/G cg27205649 chr11:78285834 NARS2 0.48 6.19 0.32 1.77e-9 Alzheimer's disease (survival time); CRC cis rs6964587 1.000 rs35653487 chr7:91745441 C/G cg17063962 chr7:91808500 NA 0.83 14.57 0.63 1.95e-37 Breast cancer; CRC trans rs10982213 0.830 rs2274163 chr9:117188714 C/T cg08830818 chr3:122514143 HSPBAP1;DIRC2 0.36 6.37 0.33 6.36e-10 Interleukin-6 levels; CRC cis rs2204008 0.782 rs11514339 chr12:38236670 G/A cg13010199 chr12:38710504 ALG10B 0.46 5.85 0.31 1.19e-8 Bladder cancer; CRC cis rs4713118 0.513 rs149989 chr6:27998184 T/A cg02683197 chr6:28174875 NA 0.61 8.5 0.42 6.89e-16 Parkinson's disease; CRC cis rs4689592 0.503 rs56099074 chr4:7071259 A/G cg26116260 chr4:7069785 GRPEL1 -0.91 -11.41 -0.53 1.21e-25 Monocyte percentage of white cells; CRC cis rs4938330 0.629 rs12269901 chr11:116973929 C/G cg01368799 chr11:117014884 PAFAH1B2 -0.46 -6.82 -0.35 4.31e-11 Blood protein levels; CRC cis rs728616 0.717 rs111403425 chr10:81820542 C/T cg05935833 chr10:81318306 SFTPA2 -0.56 -6.36 -0.33 6.81e-10 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs67311347 0.956 rs4974029 chr3:40521318 C/G cg09455208 chr3:40491958 NA 0.47 9.47 0.46 5.85e-19 Renal cell carcinoma; CRC cis rs7572644 0.699 rs1506537 chr2:28181901 G/C cg27432699 chr2:27873401 GPN1 -0.4 -5.62 -0.3 4.01e-8 Response to carboplatin and paclitaxel in ovarian cancer (Caspase 3/7 EC50); CRC cis rs9814567 0.929 rs9838834 chr3:134207077 G/A cg06541857 chr3:134203789 ANAPC13;CEP63 -0.38 -5.72 -0.3 2.36e-8 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs7772486 0.754 rs697054 chr6:146003770 C/T cg13319975 chr6:146136371 FBXO30 -0.44 -6.37 -0.33 6.49e-10 Lobe attachment (rater-scored or self-reported); CRC cis rs7618915 0.501 rs3733039 chr3:52719088 C/T cg08222913 chr3:52553049 STAB1 -0.34 -6.36 -0.33 6.78e-10 Bipolar disorder; CRC cis rs881375 0.967 rs1930780 chr9:123686219 C/G cg09419670 chr9:123605666 PSMD5;LOC253039 0.58 8.45 0.42 9.62e-16 Rheumatoid arthritis; CRC cis rs16975963 0.644 rs11666738 chr19:38130319 C/G cg15135657 chr19:38346511 NA -0.45 -6.4 -0.33 5.4e-10 Longevity; CRC cis rs7654585 0.645 rs6828416 chr4:25933273 C/T cg10409131 chr4:25915609 C4orf52 0.55 7.54 0.38 4.57e-13 Obesity-related traits; CRC cis rs644799 1.000 rs481630 chr11:95582447 G/C cg25478527 chr11:95522999 CEP57;FAM76B 0.52 7.86 0.4 5.4e-14 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs2404602 0.735 rs2280306 chr15:76652258 C/G cg03037974 chr15:76606532 NA -0.49 -7.29 -0.37 2.38e-12 Blood metabolite levels; CRC cis rs12618769 0.652 rs72823788 chr2:99213080 C/T cg18455616 chr2:99124870 INPP4A 0.35 5.82 0.31 1.41e-8 Bipolar disorder; CRC cis rs684232 0.800 rs865702 chr17:568153 A/T cg15660573 chr17:549704 VPS53 -0.43 -6.19 -0.32 1.79e-9 Prostate cancer; CRC cis rs1799949 1.000 rs8176212 chr17:41226601 G/C cg05368731 chr17:41323189 NBR1 0.69 10.39 0.5 4.77e-22 Menopause (age at onset); CRC trans rs1814175 0.754 rs28593359 chr11:50042357 C/T cg11707556 chr5:10655725 ANKRD33B -0.42 -8.03 -0.4 1.75e-14 Height; CRC cis rs7618915 0.547 rs4687548 chr3:52666650 A/T cg11645453 chr3:52864694 ITIH4 0.36 6.23 0.32 1.41e-9 Bipolar disorder; CRC trans rs8002861 0.901 rs9525867 chr13:44463557 G/A cg17145862 chr1:211918768 LPGAT1 0.77 15.42 0.65 9.57e-41 Leprosy; CRC cis rs7647973 1.000 rs974495 chr3:49400482 T/C cg07636037 chr3:49044803 WDR6 0.66 8.27 0.41 3.29e-15 Menarche (age at onset); CRC cis rs7605378 0.528 rs281791 chr2:200850402 A/G cg17644776 chr2:200775616 C2orf69 -0.46 -7.13 -0.37 6.22e-12 Osteoporosis; CRC cis rs473651 0.904 rs62196716 chr2:239356977 C/G cg21699342 chr2:239360505 ASB1 0.58 10.6 0.5 8.84e-23 Multiple system atrophy; CRC cis rs11809207 0.568 rs1892494 chr1:26497626 C/G cg24519413 chr1:26490540 NA 0.38 6.35 0.33 7.05e-10 Height; CRC cis rs1707322 1.000 rs4454479 chr1:46423555 G/A cg06784218 chr1:46089804 CCDC17 0.51 9.06 0.45 1.19e-17 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs35306767 0.903 rs11253488 chr10:922482 G/C cg20503657 chr10:835505 NA 0.96 12.2 0.56 1.71e-28 Eosinophil percentage of granulocytes; CRC cis rs9486715 0.838 rs7452350 chr6:96883326 C/A cg18709589 chr6:96969512 KIAA0776 0.47 7.01 0.36 1.34e-11 Headache; CRC cis rs2559856 0.935 rs2559864 chr12:102084710 C/G cg12924262 chr12:102091054 CHPT1 0.56 8.28 0.42 3.15e-15 Blood protein levels; CRC cis rs10504229 0.775 rs17805146 chr8:58161484 G/A cg24829409 chr8:58192753 C8orf71 -0.6 -8.04 -0.41 1.67e-14 Developmental language disorder (linguistic errors); CRC cis rs2404602 0.692 rs3816266 chr15:76993835 T/G cg23625390 chr15:77176239 SCAPER 0.49 7.26 0.37 2.76e-12 Blood metabolite levels; CRC cis rs6570726 0.599 rs4398765 chr6:145935006 C/A cg23711669 chr6:146136114 FBXO30 0.62 9.07 0.45 1.08e-17 Lobe attachment (rater-scored or self-reported); CRC cis rs2242116 0.796 rs4587 chr3:46963502 T/C cg02527881 chr3:46936655 PTH1R -0.48 -8.4 -0.42 1.37e-15 Birth weight; CRC cis rs3091242 0.967 rs665372 chr1:25719235 A/C cg27572855 chr1:25598939 RHD 0.35 6.2 0.32 1.7e-9 Erythrocyte sedimentation rate; CRC cis rs9322193 0.923 rs10872649 chr6:150080590 T/G cg00933542 chr6:150070202 PCMT1 0.33 6.97 0.36 1.73e-11 Lung cancer; CRC cis rs79349575 0.783 rs62075839 chr17:46996434 G/C cg00947319 chr17:47005597 UBE2Z -0.34 -5.87 -0.31 1.06e-8 Type 2 diabetes; CRC cis rs7246657 0.943 rs34603719 chr19:37794528 T/G cg23950597 chr19:37808831 NA -0.52 -6.09 -0.32 3.19e-9 Coronary artery calcification; CRC cis rs754466 0.580 rs17516020 chr10:79538734 C/T cg17075019 chr10:79541650 NA -0.76 -10.32 -0.49 8.08e-22 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs6952808 0.630 rs10239050 chr7:2158390 A/G cg22963979 chr7:1858916 MAD1L1 -0.43 -6.29 -0.33 1e-9 Bipolar disorder and schizophrenia; CRC cis rs597539 0.652 rs553875 chr11:68695144 T/G cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.86 14.13 0.61 8.98e-36 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs2839186 0.771 rs13049175 chr21:47641326 G/A cg13126279 chr21:47581558 C21orf56 0.54 8.82 0.44 7.05e-17 Testicular germ cell tumor; CRC trans rs561341 0.769 rs8074383 chr17:30178793 C/T cg27661571 chr11:113659931 NA 0.72 7.69 0.39 1.71e-13 Hip circumference adjusted for BMI; CRC cis rs55823223 0.564 rs12103594 chr17:73855279 C/T cg08125733 chr17:73851984 WBP2 0.72 9.09 0.45 9.41e-18 Psoriasis; CRC cis rs7727544 0.507 rs11741341 chr5:131570218 A/G cg27615366 chr5:131592974 PDLIM4 0.34 6.32 0.33 8.75e-10 Blood metabolite levels; CRC trans rs6413860 0.688 rs10802435 chr1:246859404 G/A cg25623271 chr1:240656217 GREM2 0.44 6.17 0.32 2.04e-9 Gut microbiome composition (summer); CRC cis rs7945705 0.902 rs11042152 chr11:9020987 C/T cg21881798 chr11:8931708 C11orf17;ST5 0.63 9.52 0.46 3.96e-19 Hemoglobin concentration; CRC cis rs6445967 1.000 rs14927 chr3:58305033 G/T cg23715586 chr3:58305044 RPP14 -0.36 -5.89 -0.31 9.71e-9 Platelet count; CRC cis rs2462686 1.000 rs1534150 chr7:45985290 T/C cg15898840 chr7:45960834 IGFBP3 -0.39 -5.77 -0.3 1.87e-8 Major depressive disorder; CRC cis rs9928842 0.765 rs2870467 chr16:75223881 A/G cg09066997 chr16:75300724 BCAR1 0.66 6.19 0.32 1.77e-9 Alcoholic chronic pancreatitis; CRC cis rs4713118 0.955 rs9380010 chr6:27683572 A/G cg06470822 chr6:28175283 NA 0.67 9.07 0.45 1.1e-17 Parkinson's disease; CRC cis rs7605378 1.000 rs769954 chr2:200692159 C/G cg17644776 chr2:200775616 C2orf69 -0.4 -5.73 -0.3 2.3e-8 Osteoporosis; CRC cis rs4692589 1.000 rs4321597 chr4:170934424 C/T cg19918862 chr4:170955249 NA 0.38 6.22 0.32 1.48e-9 Anxiety disorder; CRC cis rs6952808 0.717 rs10950422 chr7:1926577 T/C cg02951883 chr7:2050386 MAD1L1 -0.55 -9.28 -0.46 2.36e-18 Bipolar disorder and schizophrenia; CRC cis rs10751667 1.000 rs7395632 chr11:958789 C/T ch.11.42038R chr11:967971 AP2A2 -0.63 -10.32 -0.49 8.4e-22 Alzheimer's disease (late onset); CRC cis rs2204008 0.776 rs8186824 chr12:38316537 A/C cg26384229 chr12:38710491 ALG10B 0.66 9.51 0.46 4.18e-19 Bladder cancer; CRC cis rs6502050 0.835 rs10163485 chr17:80110750 C/T cg02741985 chr17:80059408 CCDC57 0.43 7.15 0.37 5.66e-12 Life satisfaction; CRC cis rs17270561 0.609 rs1317510 chr6:25778924 T/C cg16482183 chr6:26056742 HIST1H1C 0.73 9.1 0.45 9.03e-18 Iron status biomarkers; CRC cis rs7703051 0.585 rs918623 chr5:74596682 A/C cg19683494 chr5:74908142 NA 0.53 6.77 0.35 5.88e-11 LDL cholesterol;Age-related disease endophenotypes;Age-related diseases, mortality and associated endophenotypes; CRC cis rs7811142 1.000 rs11761725 chr7:100039815 C/T cg00814883 chr7:100076585 TSC22D4 -0.79 -9.9 -0.48 2.1e-20 Platelet count; CRC cis rs4862750 0.872 rs6821507 chr4:187876829 G/T cg22105103 chr4:187893119 NA -0.63 -11.62 -0.54 2.13e-26 Lobe attachment (rater-scored or self-reported); CRC cis rs1005277 0.579 rs1740735 chr10:38497777 A/C cg03665457 chr10:38645376 HSD17B7P2 -0.42 -5.98 -0.31 5.93e-9 Extrinsic epigenetic age acceleration; CRC cis rs35762459 1 rs35762459 chr11:8844653 T/TA cg12365402 chr11:9010492 NRIP3 -0.37 -6.11 -0.32 2.81e-9 Immature fraction of reticulocytes; CRC cis rs4689592 0.619 rs3796908 chr4:7061378 G/A cg06697600 chr4:7070879 GRPEL1 -0.55 -7.99 -0.4 2.37e-14 Monocyte percentage of white cells; CRC cis rs9457247 1.000 rs400837 chr6:167411008 T/C cg23791538 chr6:167370224 RNASET2 -0.39 -6.08 -0.32 3.37e-9 Crohn's disease; CRC cis rs9372498 0.536 rs62424195 chr6:118812108 T/A cg18833306 chr6:118973337 C6orf204 0.45 5.88 0.31 1.01e-8 Diastolic blood pressure; CRC cis rs881375 0.631 rs2416808 chr9:123706283 G/A cg09419670 chr9:123605666 PSMD5;LOC253039 0.5 7.99 0.4 2.37e-14 Rheumatoid arthritis; CRC cis rs7044106 0.708 rs10984992 chr9:123473416 G/A cg14255062 chr9:123606675 PSMD5;LOC253039 0.47 7.11 0.36 7.24e-12 Hip circumference adjusted for BMI; CRC trans rs10242455 0.702 rs6976017 chr7:99249999 G/A cg09045935 chr12:6379348 NA 0.92 6.84 0.35 3.8e-11 Blood metabolite levels; CRC cis rs832540 0.519 rs10039338 chr5:56260363 C/T cg18230493 chr5:56204884 C5orf35 0.37 5.74 0.3 2.18e-8 Coronary artery disease; CRC cis rs9522267 0.535 rs7323829 chr13:112232308 C/G cg26182253 chr13:112236782 NA 0.31 6.25 0.33 1.26e-9 Hepatitis; CRC cis rs11098499 0.863 rs10009626 chr4:120470005 T/C cg09307838 chr4:120376055 NA 0.67 10.3 0.49 9.15e-22 Corneal astigmatism; CRC cis rs6684514 0.961 rs112017075 chr1:156327716 G/A cg16558208 chr1:156270281 VHLL 0.54 8.19 0.41 5.71e-15 Mean corpuscular hemoglobin concentration;Glycated hemoglobin levels; CRC cis rs1018836 0.923 rs2213886 chr8:91554163 G/C cg16814680 chr8:91681699 NA -0.77 -12.68 -0.57 2.79e-30 Ejection fraction in Tripanosoma cruzi seropositivity; CRC cis rs7615952 0.599 rs6438955 chr3:125730333 C/A cg18479299 chr3:125709523 NA -0.5 -6.43 -0.33 4.44e-10 Blood pressure (smoking interaction); CRC cis rs4728302 0.838 rs10225605 chr7:133591676 G/A cg03336402 chr7:133662267 EXOC4 -0.45 -6.56 -0.34 2.04e-10 Intelligence;Intelligence (multi-trait analysis); CRC cis rs17270561 0.609 rs9358877 chr6:25739228 A/G cg16482183 chr6:26056742 HIST1H1C 0.83 10.58 0.5 1.07e-22 Iron status biomarkers; CRC trans rs2084898 0.891 rs504236 chr11:120000263 T/C cg10387956 chr15:72646210 HEXA 0.68 6.27 0.33 1.12e-9 Stroke (pediatric); CRC cis rs929596 0.785 rs34352510 chr2:234650562 T/C cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.74 -11.03 -0.52 2.81e-24 Total bilirubin levels in HIV-1 infection; CRC cis rs7605827 0.893 rs2098463 chr2:15512175 C/G cg19274914 chr2:15703543 NA 0.38 5.8 0.3 1.59e-8 Educational attainment (years of education); CRC cis rs3087591 0.597 rs731759 chr17:29722809 A/T cg24425628 chr17:29625626 OMG;NF1 -0.58 -9.87 -0.48 2.69e-20 Hip circumference; CRC cis rs116095464 0.558 rs9687898 chr5:253952 A/G cg22496380 chr5:211416 CCDC127 -0.91 -10.46 -0.5 2.65e-22 Breast cancer; CRC cis rs6496667 1.000 rs8042825 chr15:90897885 C/G cg04176472 chr15:90893244 GABARAPL3 -0.49 -7.33 -0.37 1.82e-12 Rheumatoid arthritis; CRC cis rs79387448 0.745 rs17027428 chr2:103163175 G/A cg09003973 chr2:102972529 NA 0.73 8.01 0.4 1.97e-14 Gut microbiota (bacterial taxa); CRC cis rs6952808 0.575 rs2056479 chr7:1954273 G/A cg02951883 chr7:2050386 MAD1L1 -0.52 -8.61 -0.43 3.09e-16 Bipolar disorder and schizophrenia; CRC cis rs40363 0.645 rs1690450 chr16:3521051 G/A cg00484396 chr16:3507460 NAT15 0.57 8.86 0.44 5.01e-17 Tuberculosis; CRC cis rs2302777 0.507 rs9889716 chr17:38108298 A/G cg17344932 chr17:38183730 MED24;SNORD124 -0.56 -8.92 -0.44 3.24e-17 Multiple myeloma (hyperdiploidy); CRC cis rs4423214 0.802 rs2276358 chr11:71184498 G/A cg05163923 chr11:71159392 DHCR7 -0.63 -7.61 -0.39 2.92e-13 Vitamin D levels; CRC cis rs965469 1.000 rs2236107 chr20:3285821 C/T cg25506879 chr20:3388711 C20orf194 -0.4 -5.7 -0.3 2.69e-8 IFN-related cytopenia; CRC cis rs3767633 1.000 rs3767633 chr1:161826615 T/A cg09175582 chr1:161736000 ATF6 0.7 6.29 0.33 1.03e-9 IgG glycosylation; CRC cis rs28374715 0.681 rs7165396 chr15:41586947 T/C cg18705301 chr15:41695430 NDUFAF1 -1.09 -18.12 -0.71 2.13e-51 Ulcerative colitis; CRC cis rs7725052 0.609 rs4523044 chr5:40468024 C/T cg09067459 chr5:40385259 NA 0.4 6.57 0.34 1.94e-10 Pediatric autoimmune diseases; CRC cis rs7772486 0.754 rs4895682 chr6:146062861 G/A cg23711669 chr6:146136114 FBXO30 -0.75 -12.72 -0.57 2.06e-30 Lobe attachment (rater-scored or self-reported); CRC cis rs9733 0.596 rs72702552 chr1:150677462 G/A cg17724175 chr1:150552817 MCL1 0.6 9.66 0.47 1.39e-19 Tonsillectomy; CRC trans rs10982213 0.830 rs2274163 chr9:117188714 C/T cg01956267 chr2:158732380 ACVR1 0.4 5.97 0.31 6.2e-9 Interleukin-6 levels; CRC cis rs362272 0.545 rs2748447 chr4:3337831 G/A cg11522145 chr4:3412961 RGS12 -0.41 -6.36 -0.33 6.67e-10 Serum sulfate level; CRC cis rs12580194 0.593 rs13377995 chr12:55757380 C/G cg19537932 chr12:55886519 OR6C68 -0.67 -8.83 -0.44 6.47e-17 Cancer; CRC cis rs875971 0.862 rs709609 chr7:65560561 A/G cg18876405 chr7:65276391 NA -0.51 -8.49 -0.42 6.96e-16 Aortic root size; CRC cis rs3806843 0.576 rs155363 chr5:140301543 A/G cg19875535 chr5:140030758 IK 0.44 6.72 0.35 8.07e-11 Depressive symptoms (multi-trait analysis); CRC cis rs9443645 0.901 rs6940637 chr6:79705845 C/T cg09184832 chr6:79620586 NA -0.51 -9.35 -0.46 1.41e-18 Intelligence (multi-trait analysis); CRC cis rs28386778 0.562 rs721575 chr17:61782920 A/G cg23090583 chr17:61904693 PSMC5;FTSJ3 -0.85 -14.42 -0.62 6.98e-37 Prudent dietary pattern; CRC cis rs6938 0.575 rs12902515 chr15:75160998 G/C cg05627522 chr15:75251581 NA 0.37 5.71 0.3 2.53e-8 Breast cancer; CRC cis rs2948294 0.588 rs4840913 chr8:8116906 A/C cg08975724 chr8:8085496 FLJ10661 0.43 5.75 0.3 2.07e-8 Red cell distribution width; CRC cis rs6502050 0.749 rs7406163 chr17:80086389 C/T cg22110888 chr17:80059540 CCDC57 -0.41 -6.46 -0.34 3.81e-10 Life satisfaction; CRC cis rs9486715 0.867 rs9373907 chr6:96981189 G/A cg18709589 chr6:96969512 KIAA0776 0.4 5.63 0.3 3.95e-8 Headache; CRC trans rs1962073 0.623 rs7459532 chr8:10261068 C/T cg16141378 chr3:129829833 LOC729375 0.39 6.09 0.32 3.23e-9 Response to chemotherapy in breast cancer hypertensive cases (cumulative dose) (bevacizumab); CRC cis rs3858526 0.833 rs4758184 chr11:5926719 A/G cg02574844 chr11:5959923 NA -0.41 -5.69 -0.3 2.87e-8 DNA methylation (variation); CRC cis rs2502731 1.000 rs2502731 chr9:130976557 A/G cg09976142 chr9:130955436 CIZ1 -0.5 -8.44 -0.42 1.01e-15 Attention deficit hyperactivity disorder; CRC cis rs910187 0.678 rs6122561 chr20:45813809 A/G cg27589058 chr20:45804311 EYA2 -0.37 -7.31 -0.37 1.99e-12 Migraine; CRC cis rs11122272 0.735 rs2749714 chr1:231538634 G/C cg06096015 chr1:231504339 EGLN1 0.42 6.2 0.32 1.74e-9 Hemoglobin concentration; CRC cis rs9733 0.519 rs3768005 chr1:150680988 A/T cg17724175 chr1:150552817 MCL1 0.6 9.51 0.46 4.03e-19 Tonsillectomy; CRC cis rs7249142 0.549 rs539 chr19:19287802 A/G cg12558012 chr19:19281197 LOC729991-MEF2B;MEF2B 0.6 9.44 0.46 6.92e-19 IgG glycosylation; CRC cis rs6502050 0.871 rs6502055 chr17:80070868 G/T cg13198984 chr17:80129470 CCDC57 -0.46 -7.86 -0.4 5.37e-14 Life satisfaction; CRC cis rs9914988 0.619 rs35477460 chr17:27320276 C/T cg16670446 chr17:27188758 MIR451;MIR144 0.48 6.53 0.34 2.47e-10 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs8177253 0.761 rs35332919 chr3:133519002 T/A cg11941060 chr3:133502564 NA -0.69 -12.2 -0.56 1.66e-28 Iron status biomarkers; CRC cis rs6840360 0.615 rs28659854 chr4:152607442 T/C cg09659197 chr4:152720779 NA 0.4 7.84 0.4 6.22e-14 Intelligence (multi-trait analysis); CRC cis rs6502050 0.835 rs4459614 chr17:80086597 C/T cg11859384 chr17:80120422 CCDC57 0.37 5.66 0.3 3.24e-8 Life satisfaction; CRC cis rs728616 0.558 rs12772945 chr10:82154496 C/T cg05935833 chr10:81318306 SFTPA2 -0.58 -6.97 -0.36 1.74e-11 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs3858526 0.834 rs7128847 chr11:6003111 C/T cg13902645 chr11:5959945 NA -0.54 -6.85 -0.35 3.6e-11 DNA methylation (variation); CRC cis rs12477438 0.520 rs2632283 chr2:99776000 C/G cg14399236 chr2:99771627 LIPT1;TSGA10 0.73 12.17 0.56 2.24e-28 Chronic sinus infection; CRC cis rs2204008 0.775 rs11182513 chr12:38560252 G/C cg26384229 chr12:38710491 ALG10B 0.7 9.43 0.46 7.85e-19 Bladder cancer; CRC cis rs910316 0.737 rs2098251 chr14:75492696 G/A cg08847533 chr14:75593920 NEK9 0.84 14.65 0.63 9e-38 Height; CRC cis rs1865760 1.000 rs2071301 chr6:25914263 G/T cg16482183 chr6:26056742 HIST1H1C 0.52 7.49 0.38 6.41e-13 Height; CRC cis rs12188164 0.502 rs55929184 chr5:405576 G/A cg17553881 chr5:443987 EXOC3;C5orf55 -0.33 -6.65 -0.34 1.26e-10 Cystic fibrosis severity; CRC cis rs736408 0.609 rs13082208 chr3:52781539 T/G cg05573699 chr3:52720067 GNL3;PBRM1 -0.45 -6.32 -0.33 8.33e-10 Bipolar disorder; CRC cis rs11105298 0.891 rs10858865 chr12:89846476 G/A cg08166232 chr12:89918718 WDR51B;GALNT4 -0.61 -7.74 -0.39 1.27e-13 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; CRC cis rs4654899 1.000 rs4654899 chr1:21410231 G/T cg02927042 chr1:21476669 EIF4G3 -0.46 -7.45 -0.38 8.1e-13 Superior frontal gyrus grey matter volume; CRC trans rs7395662 0.853 rs35255233 chr11:48442870 T/A cg21153622 chr11:89784906 NA -0.46 -7.26 -0.37 2.75e-12 HDL cholesterol; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg09864156 chr10:70939728 SUPV3L1 0.42 6.0 0.31 5.29e-9 Response to antipsychotic treatment; CRC cis rs4713118 0.513 rs183244 chr6:28031838 C/A cg18032046 chr6:28092343 ZSCAN16 -0.45 -5.99 -0.31 5.44e-9 Parkinson's disease; CRC cis rs6121246 0.954 rs6060989 chr20:30429763 C/T cg13852791 chr20:30311386 BCL2L1 0.63 10.07 0.49 5.54e-21 Mean corpuscular hemoglobin; CRC cis rs2836974 0.863 rs12483216 chr21:40539614 T/C cg11644478 chr21:40555479 PSMG1 0.81 12.73 0.57 1.92e-30 Cognitive function; CRC cis rs1030268 0.651 rs12707118 chr7:133474900 C/T cg10665199 chr7:133106180 EXOC4 -0.53 -6.16 -0.32 2.16e-9 Intelligence (multi-trait analysis); CRC cis rs7617773 0.539 rs13094496 chr3:48387050 G/C cg11946769 chr3:48343235 NME6 0.61 8.34 0.42 2.03e-15 Coronary artery disease; CRC cis rs951366 0.789 rs823130 chr1:205714372 C/T cg26354017 chr1:205819088 PM20D1 0.74 11.13 0.52 1.21e-24 Menarche (age at onset); CRC cis rs2153535 0.580 rs6920779 chr6:8437624 C/T cg07606381 chr6:8435919 SLC35B3 0.68 10.89 0.51 8.99e-24 Motion sickness; CRC cis rs10911232 0.507 rs4652766 chr1:182994336 A/G ch.1.3577855R chr1:183094577 LAMC1 0.87 15.17 0.64 8.94e-40 Hypertriglyceridemia; CRC cis rs10504229 0.724 rs58715581 chr8:58134568 A/G cg04204079 chr8:58130323 NA -0.45 -5.78 -0.3 1.71e-8 Developmental language disorder (linguistic errors); CRC trans rs2832077 0.943 rs2832091 chr21:30162855 C/T cg14791747 chr16:20752902 THUMPD1 0.56 7.0 0.36 1.46e-11 Cognitive test performance; CRC cis rs7493 1.000 rs2299265 chr7:95048870 C/G cg01874867 chr7:94954059 PON1 -0.51 -6.42 -0.33 4.74e-10 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs6540556 0.859 rs11119341 chr1:209940675 A/G cg05527609 chr1:210001259 C1orf107 0.49 6.14 0.32 2.34e-9 Red blood cell count; CRC cis rs6499255 0.951 rs8052086 chr16:69692468 A/C cg15192750 chr16:69999425 NA 0.59 7.93 0.4 3.45e-14 IgE levels; CRC cis rs1129187 0.719 rs3805953 chr6:42936900 C/T cg03790207 chr6:42947109 PEX6 -0.49 -6.97 -0.36 1.77e-11 Alzheimer's disease in APOE e4+ carriers; CRC trans rs629535 0.862 rs654604 chr8:70048939 C/A cg21567404 chr3:27674614 NA 0.95 16.08 0.66 2.35e-43 Dupuytren's disease; CRC cis rs11711311 1.000 rs9828449 chr3:113518602 T/C cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.52 -7.08 -0.36 8.63e-12 IgG glycosylation; CRC cis rs1448094 0.512 rs1349063 chr12:86264237 C/T cg19622623 chr12:86230825 RASSF9 -0.41 -6.6 -0.34 1.62e-10 Major depressive disorder; CRC cis rs55702914 0.809 rs6738721 chr2:198182334 A/G cg20885578 chr2:198174922 NA -0.34 -5.84 -0.31 1.28e-8 Major depression and alcohol dependence; CRC cis rs12928939 0.911 rs7202840 chr16:71824714 C/T cg08717414 chr16:71523259 ZNF19 -0.51 -6.32 -0.33 8.64e-10 Post bronchodilator FEV1; CRC cis rs2224391 1.000 rs9784870 chr6:5261359 A/G cg09085698 chr6:5261316 LYRM4;FARS2 -0.44 -5.76 -0.3 1.98e-8 Height; CRC cis rs73200209 0.744 rs73198012 chr12:116463855 G/A cg01776926 chr12:116560359 MED13L -0.59 -6.67 -0.35 1.08e-10 Total body bone mineral density; CRC cis rs4664293 0.967 rs10176436 chr2:160515394 G/A cg08347373 chr2:160653686 CD302 -0.37 -6.15 -0.32 2.21e-9 Monocyte percentage of white cells; CRC cis rs56114371 0.530 rs9348774 chr6:27688930 C/T cg26587870 chr6:27730563 NA -0.43 -6.01 -0.31 4.83e-9 Breast cancer; CRC cis rs2197308 0.605 rs2387437 chr12:37919367 T/C cg13010199 chr12:38710504 ALG10B 0.45 5.99 0.31 5.52e-9 Morning vs. evening chronotype; CRC cis rs6582630 0.519 rs11520262 chr12:38333051 A/G cg13010199 chr12:38710504 ALG10B 0.46 6.08 0.32 3.31e-9 Drug-induced liver injury (flucloxacillin); CRC cis rs9372498 0.536 rs9481833 chr6:118919631 G/A cg15382696 chr6:118971807 C6orf204 0.6 7.72 0.39 1.38e-13 Diastolic blood pressure; CRC cis rs9682041 0.740 rs2111826 chr3:170140846 A/G cg11886554 chr3:170076028 SKIL 1.04 10.12 0.49 3.75e-21 Glomerular filtration rate in non diabetics (creatinine);Glomerular filtration rate (creatinine); CRC cis rs10540 1.000 rs61876340 chr11:495699 A/C cg03576123 chr11:487126 PTDSS2 -1.04 -10.79 -0.51 1.91e-23 Body mass index; CRC cis rs55665837 1.000 rs10832268 chr11:14465068 C/A cg19336497 chr11:14380999 RRAS2 -0.38 -6.54 -0.34 2.29e-10 Vitamin D levels; CRC cis rs7772486 0.875 rs9322044 chr6:146369608 T/C cg05347473 chr6:146136440 FBXO30 0.36 5.66 0.3 3.36e-8 Lobe attachment (rater-scored or self-reported); CRC cis rs7937682 0.663 rs35581942 chr11:111756286 C/T cg19812747 chr11:111475976 SIK2 0.42 6.08 0.32 3.39e-9 Primary sclerosing cholangitis; CRC cis rs10876993 0.928 rs2640629 chr12:58065448 C/T cg15848620 chr12:58087721 OS9 -0.61 -8.58 -0.43 3.82e-16 Celiac disease or Rheumatoid arthritis; CRC trans rs2303319 0.504 rs62189054 chr2:162624654 C/G cg20024234 chr21:43431083 ZNF295 -0.66 -5.96 -0.31 6.5e-9 Cognitive function; CRC cis rs7089973 0.872 rs3180654 chr10:116615045 T/C cg03647239 chr10:116582469 FAM160B1 0.41 5.75 0.3 2.01e-8 Bipolar disorder or attention deficit hyperactivity disorder; CRC cis rs6424115 1.000 rs974698 chr1:24132785 C/T cg09473613 chr1:24152604 HMGCL 0.34 5.87 0.31 1.07e-8 Immature fraction of reticulocytes; CRC cis rs798554 1.000 rs798544 chr7:2763102 A/G cg05055821 chr7:2758924 NA 0.36 5.63 0.3 3.85e-8 Height; CRC cis rs736408 0.527 rs2577831 chr3:52628056 C/A cg11645453 chr3:52864694 ITIH4 0.36 6.62 0.34 1.46e-10 Bipolar disorder; CRC cis rs9807989 0.507 rs1592459 chr2:103031569 A/G cg03938978 chr2:103052716 IL18RAP 0.59 10.13 0.49 3.5e-21 Asthma; CRC cis rs7584330 0.737 rs1390985 chr2:238367420 G/A cg11271282 chr2:238384023 NA 0.43 5.78 0.3 1.74e-8 Prostate cancer; CRC cis rs17227506 0.693 rs4531057 chr8:13457799 C/T cg03566418 chr8:13424080 C8orf48 -0.35 -5.99 -0.31 5.61e-9 Nonsyndromic cleft lip with cleft palate; CRC cis rs897984 0.511 rs7196726 chr16:31092075 G/A cg02466173 chr16:30829666 NA -0.59 -8.99 -0.44 2.04e-17 Dementia with Lewy bodies; CRC cis rs317689 0.690 rs595348 chr12:69638610 T/C cg20891283 chr12:69753455 YEATS4 0.47 6.07 0.32 3.44e-9 Response to diuretic therapy; CRC cis rs3096299 0.658 rs12443705 chr16:89547054 C/G cg08392591 chr16:89556376 ANKRD11 0.43 5.87 0.31 1.06e-8 Multiple myeloma (IgH translocation); CRC cis rs11711311 0.955 rs12634241 chr3:113397685 T/C cg15478005 chr3:113465772 ATP6V1A;NAA50 0.43 5.8 0.3 1.59e-8 IgG glycosylation; CRC trans rs61931739 0.517 rs12816423 chr12:34067736 G/A cg26384229 chr12:38710491 ALG10B 0.54 6.86 0.35 3.41e-11 Morning vs. evening chronotype; CRC cis rs863345 0.967 rs10908680 chr1:158521961 T/C cg12129480 chr1:158549410 OR10X1 -0.26 -5.65 -0.3 3.44e-8 Pneumococcal bacteremia; CRC cis rs2882667 0.690 rs17031 chr5:138270542 A/T cg09476006 chr5:138032270 NA 0.53 8.85 0.44 5.33e-17 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs9399135 0.967 rs4895436 chr6:135295001 G/A cg22676075 chr6:135203613 NA 0.43 6.69 0.35 9.9e-11 Red blood cell count; CRC cis rs79349575 0.783 rs62075818 chr17:46982327 T/A cg00947319 chr17:47005597 UBE2Z -0.34 -5.91 -0.31 8.38e-9 Type 2 diabetes; CRC cis rs8180040 1.000 rs4858888 chr3:47405305 C/T cg02527881 chr3:46936655 PTH1R 0.36 6.49 0.34 3.23e-10 Colorectal cancer; CRC cis rs9910055 0.659 rs7212573 chr17:42254281 A/G cg09913183 chr17:42254507 C17orf65;ASB16 0.65 10.15 0.49 3.15e-21 Total body bone mineral density; CRC cis rs10089 0.953 rs1012851 chr5:127360241 T/C cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.73 10.64 0.51 6.47e-23 Ileal carcinoids; CRC cis rs1799949 0.536 rs4793227 chr17:41412250 A/C cg25072359 chr17:41440525 NA 0.53 8.48 0.42 7.71e-16 Menopause (age at onset); CRC cis rs853679 0.517 rs3734573 chr6:28059437 T/C cg02631126 chr6:28058918 ZSCAN12L1 0.3 6.09 0.32 3.18e-9 Depression; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg10132348 chr4:6784379 KIAA0232 0.38 6.26 0.33 1.2e-9 Liver disease severity in Alagille syndrome; CRC cis rs861020 0.771 rs661849 chr1:210001233 C/T cg09163369 chr1:210001066 C1orf107 0.62 8.29 0.42 2.99e-15 Orofacial clefts; CRC trans rs6762477 0.748 rs3755831 chr3:50228767 G/T cg21665057 chr3:196295764 WDR53;FBXO45 -0.44 -6.7 -0.35 9.11e-11 Menarche (age at onset); CRC cis rs1865760 0.566 rs1539183 chr6:26075051 G/C cg17691542 chr6:26056736 HIST1H1C 0.56 8.51 0.42 6.43e-16 Height; CRC cis rs2976388 0.590 rs7828042 chr8:143819383 A/G cg22687807 chr8:143858763 LYNX1 -0.45 -7.44 -0.38 8.84e-13 Urinary tract infection frequency; CRC cis rs9443645 0.869 rs4706080 chr6:79760997 C/T cg11833968 chr6:79620685 NA -0.37 -6.35 -0.33 7.05e-10 Intelligence (multi-trait analysis); CRC cis rs637571 0.522 rs7105628 chr11:65763067 C/T cg26695010 chr11:65641043 EFEMP2 -0.41 -6.08 -0.32 3.42e-9 Eosinophil percentage of white cells; CRC cis rs8017423 0.647 rs12882575 chr14:90820454 C/G cg14092571 chr14:90743983 NA 0.39 5.98 0.31 5.81e-9 Mortality in heart failure; CRC cis rs796364 1.000 rs281783 chr2:200751582 G/A cg12253985 chr2:200820533 C2orf60;C2orf47 0.61 6.84 0.35 3.79e-11 Schizophrenia; CRC trans rs7613875 0.620 rs7430334 chr3:50078221 T/C cg21665057 chr3:196295764 WDR53;FBXO45 -0.47 -7.08 -0.36 8.67e-12 Body mass index; CRC cis rs9837602 1.000 rs10212525 chr3:99713377 T/C cg07805332 chr3:99536008 MIR548G;C3orf26 -0.47 -6.2 -0.32 1.65e-9 Breast cancer; CRC cis rs6693567 0.565 rs834225 chr1:150300727 T/C cg15654264 chr1:150340011 RPRD2 0.42 6.35 0.33 7.02e-10 Migraine; CRC cis rs1348850 1.000 rs3927978 chr2:178443854 A/G cg02961200 chr2:178257176 LOC100130691;AGPS -0.56 -8.16 -0.41 7.4e-15 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs9322193 0.923 rs10747276 chr6:150079875 G/A cg13206674 chr6:150067644 NUP43 0.66 9.88 0.48 2.47e-20 Lung cancer; CRC cis rs6933660 0.800 rs9383893 chr6:151757327 T/C cg14416726 chr6:151773293 C6orf211;RMND1 -0.59 -8.74 -0.43 1.22e-16 Menarche (age at onset); CRC cis rs11249608 0.548 rs13156530 chr5:178475017 C/T cg01312482 chr5:178451176 ZNF879 -0.35 -5.77 -0.3 1.81e-8 Pubertal anthropometrics; CRC cis rs9372498 0.536 rs62424199 chr6:118827252 G/A cg22561889 chr6:118971681 C6orf204 0.51 6.6 0.34 1.69e-10 Diastolic blood pressure; CRC cis rs34172651 0.917 rs2343606 chr16:24793741 C/T cg00339695 chr16:24857497 SLC5A11 0.28 6.13 0.32 2.47e-9 Intelligence (multi-trait analysis); CRC trans rs11895698 1 rs11895698 chr2:239338495 C/T cg01134436 chr17:81009848 B3GNTL1 0.58 6.42 0.33 4.72e-10 Chronotype; CRC trans rs2727020 0.619 rs1164665 chr11:49295630 T/C cg15704280 chr7:45808275 SEPT13 0.67 8.9 0.44 3.94e-17 Coronary artery disease; CRC cis rs3733585 0.699 rs6856127 chr4:9965443 T/C cg11266682 chr4:10021025 SLC2A9 -0.47 -9.6 -0.47 2.1e-19 Cleft plate (environmental tobacco smoke interaction); CRC cis rs12477438 1.000 rs57846982 chr2:99921574 A/C cg14399236 chr2:99771627 LIPT1;TSGA10 -0.72 -8.42 -0.42 1.18e-15 Chronic sinus infection; CRC cis rs4972806 0.849 rs2857541 chr2:177029086 C/T cg10305451 chr2:177043427 NA 0.72 11.21 0.53 6.62e-25 IgG glycosylation; CRC cis rs881375 1.000 rs10760121 chr9:123647915 G/T cg14255062 chr9:123606675 PSMD5;LOC253039 0.43 6.08 0.32 3.37e-9 Rheumatoid arthritis; CRC cis rs10751667 0.857 rs7481221 chr11:966813 G/C ch.11.42038R chr11:967971 AP2A2 0.58 9.98 0.48 1.16e-20 Alzheimer's disease (late onset); CRC cis rs7666738 0.830 rs7672901 chr4:98938781 C/T cg05340658 chr4:99064831 C4orf37 0.59 9.25 0.45 2.92e-18 Colonoscopy-negative controls vs population controls; CRC cis rs9733 0.596 rs2175615 chr1:150624101 A/G cg17724175 chr1:150552817 MCL1 0.58 9.4 0.46 9.25e-19 Tonsillectomy; CRC cis rs10504229 0.683 rs903702 chr8:58128557 T/C cg24829409 chr8:58192753 C8orf71 -0.55 -8.03 -0.4 1.71e-14 Developmental language disorder (linguistic errors); CRC cis rs8180040 0.620 rs4683322 chr3:47093189 T/C cg02527881 chr3:46936655 PTH1R -0.34 -5.96 -0.31 6.66e-9 Colorectal cancer; CRC cis rs10504229 0.683 rs67077711 chr8:58139769 G/T cg04204079 chr8:58130323 NA -0.45 -5.78 -0.3 1.71e-8 Developmental language disorder (linguistic errors); CRC trans rs2303319 0.504 rs62189052 chr2:162623869 C/G cg22922770 chr7:98923339 ARPC1A -0.67 -5.99 -0.31 5.55e-9 Cognitive function; CRC cis rs3749237 0.964 rs13084243 chr3:49821878 G/C cg03060546 chr3:49711283 APEH 0.55 8.3 0.42 2.77e-15 Resting heart rate; CRC cis rs2795502 0.630 rs2282443 chr10:43474169 A/G cg20628663 chr10:43360327 NA 0.64 7.23 0.37 3.33e-12 Blood protein levels; CRC cis rs801193 1.000 rs7783924 chr7:66209057 A/C cg05627663 chr7:65219948 SNORA22;CCT6P1 0.42 6.12 0.32 2.65e-9 Aortic root size; CRC trans rs2727020 0.558 rs1164675 chr11:49325972 C/T cg03929089 chr4:120376271 NA 0.79 12.37 0.56 4.12e-29 Coronary artery disease; CRC cis rs3824347 0.804 rs10781255 chr9:77575790 C/T cg01251476 chr9:77566080 C9orf40 0.38 5.85 0.31 1.18e-8 Urinary magnesium-to-creatinine ratio; CRC cis rs2239547 0.618 rs13083728 chr3:52868445 G/A cg10802521 chr3:52805072 NEK4 -0.45 -6.1 -0.32 3.05e-9 Schizophrenia; CRC cis rs3087591 0.708 rs2525574 chr17:29705947 T/C cg24425628 chr17:29625626 OMG;NF1 0.72 13.49 0.6 2.64e-33 Hip circumference; CRC cis rs17270561 0.666 rs1141034 chr6:25780332 C/T cg17691542 chr6:26056736 HIST1H1C 0.66 8.34 0.42 2e-15 Iron status biomarkers; CRC cis rs875971 1.000 rs7801282 chr7:65613687 C/T cg18876405 chr7:65276391 NA -0.52 -8.98 -0.44 2.07e-17 Aortic root size; CRC cis rs6840360 0.967 rs1105534 chr4:152605312 C/A cg09659197 chr4:152720779 NA 0.49 10.43 0.5 3.51e-22 Intelligence (multi-trait analysis); CRC cis rs9910055 0.529 rs190144 chr17:42164584 A/G cg13607699 chr17:42295918 UBTF -0.48 -6.17 -0.32 1.98e-9 Total body bone mineral density; CRC trans rs35110281 0.776 rs2838338 chr21:45075582 T/C cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.5 8.43 0.42 1.07e-15 Mean corpuscular volume; CRC cis rs2115630 0.645 rs4842978 chr15:85197253 T/C cg11189052 chr15:85197271 WDR73 -0.73 -12.89 -0.58 4.56e-31 P wave terminal force; CRC cis rs67311347 0.544 rs6599088 chr3:40329288 T/C cg09455208 chr3:40491958 NA 0.31 6.23 0.33 1.4e-9 Renal cell carcinoma; CRC cis rs17092148 0.887 rs6059931 chr20:33175338 A/G cg08999081 chr20:33150536 PIGU 0.49 6.14 0.32 2.39e-9 Neuroticism; CRC cis rs1568889 1.000 rs7933332 chr11:28036392 T/C cg06544937 chr11:28130018 METT5D1;KIF18A 0.81 11.58 0.54 3.12e-26 Bipolar disorder; CRC cis rs526821 1.000 rs526821 chr11:55306151 A/G cg04317927 chr11:55418816 OR4S2 0.32 5.98 0.31 5.92e-9 Pediatric bone mineral density (spine); CRC cis rs2692947 0.702 rs7604842 chr2:96777340 C/T cg23100626 chr2:96804247 ASTL -0.28 -7.42 -0.38 9.81e-13 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; CRC trans rs10504229 1.000 rs78953746 chr8:58170608 A/G cg04077850 chr5:125800366 GRAMD3 0.37 6.21 0.32 1.64e-9 Developmental language disorder (linguistic errors); CRC cis rs12999616 0.602 rs905484 chr2:98590083 T/A cg26665480 chr2:98280029 ACTR1B 0.56 6.33 0.33 8.12e-10 Colorectal cancer; CRC cis rs1434579 0.966 rs7246892 chr19:44928668 A/G cg15540054 chr19:45004280 ZNF180 0.5 6.39 0.33 5.71e-10 Tuberculosis; CRC cis rs11105298 0.891 rs11105312 chr12:89920733 C/T cg00757033 chr12:89920650 WDR51B 0.36 6.06 0.32 3.79e-9 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; CRC trans rs6463739 0.965 rs6976317 chr7:7902349 C/G cg09417038 chr21:47716443 C21orf57 0.4 6.09 0.32 3.12e-9 Small cell lung carcinoma; CRC cis rs4332037 0.754 rs62436669 chr7:1926636 G/A cg25834613 chr7:1915315 MAD1L1 -0.47 -6.86 -0.35 3.37e-11 Bipolar disorder; CRC cis rs7932354 0.502 rs11600668 chr11:47193566 G/A cg19486271 chr11:47235900 DDB2 0.47 6.64 0.34 1.29e-10 Bone mineral density (hip);Bone mineral density; CRC cis rs6831352 0.877 rs28987101 chr4:100049253 T/G cg12011299 chr4:100065546 ADH4 -0.49 -9.27 -0.45 2.61e-18 Alcohol dependence; CRC cis rs4803468 1.000 rs2241710 chr19:41912092 G/C cg09537434 chr19:41945824 ATP5SL -0.98 -18.86 -0.72 2.59e-54 Height; CRC cis rs2971970 0.519 rs4728303 chr7:133633518 G/T cg03336402 chr7:133662267 EXOC4 0.63 9.63 0.47 1.65e-19 Intelligence (multi-trait analysis); CRC cis rs798554 0.567 rs2527695 chr7:2858267 T/G cg04166393 chr7:2884313 GNA12 0.37 5.67 0.3 3.05e-8 Height; CRC trans rs12599106 0.660 rs12919333 chr16:34991336 C/T cg15383120 chr6:291909 DUSP22 -0.6 -8.36 -0.42 1.76e-15 Menopause (age at onset); CRC cis rs3806843 1.000 rs2240695 chr5:140168151 G/T cg16607685 chr5:140181889 PCDHA2;PCDHA1;PCDHA3 -0.26 -5.92 -0.31 8.09e-9 Depressive symptoms (multi-trait analysis); CRC cis rs4713118 0.666 rs4140646 chr6:27738801 G/A cg15786705 chr6:28176104 NA 0.6 6.74 0.35 7.32e-11 Parkinson's disease; CRC cis rs6570726 0.935 rs369458 chr6:145812809 A/G cg05347473 chr6:146136440 FBXO30 0.37 5.89 0.31 9.78e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs2014572 0.967 rs10412975 chr19:57770554 C/A cg12963866 chr19:57752005 ZNF805 -0.44 -6.54 -0.34 2.36e-10 Hyperactive-impulsive symptoms; CRC cis rs6952808 1.000 rs6977733 chr7:1886725 A/T cg21782813 chr7:2030301 MAD1L1 -0.44 -7.36 -0.38 1.46e-12 Bipolar disorder and schizophrenia; CRC cis rs55665837 1.000 rs34980103 chr11:14512885 C/T cg19336497 chr11:14380999 RRAS2 -0.4 -6.66 -0.34 1.16e-10 Vitamin D levels; CRC cis rs892961 0.836 rs8071497 chr17:75414358 T/C cg05865280 chr17:75406074 SEPT9 0.62 14.1 0.61 1.2e-35 Airflow obstruction; CRC trans rs1814175 0.645 rs1851844 chr11:50021773 T/C cg15704280 chr7:45808275 SEPT13 -0.92 -16.92 -0.68 1.2e-46 Height; CRC cis rs8060686 0.858 rs7198357 chr16:67884619 A/G cg01951491 chr16:67709440 GFOD2 0.43 5.61 0.3 4.27e-8 HDL cholesterol;Metabolic syndrome; CRC cis rs2549003 0.966 rs10065633 chr5:131816716 T/C cg02551604 chr5:131831745 NA -0.54 -8.36 -0.42 1.76e-15 Asthma (sex interaction); CRC cis rs28386778 0.830 rs2597637 chr17:61875066 T/G cg06873352 chr17:61820015 STRADA 0.8 15.3 0.64 2.82e-40 Prudent dietary pattern; CRC trans rs1814175 0.626 rs1722008 chr11:49897676 A/T cg11707556 chr5:10655725 ANKRD33B -0.43 -8.1 -0.41 1.08e-14 Height; CRC cis rs9929218 0.953 rs11075696 chr16:68731365 A/G cg02972257 chr16:68554789 NA 0.47 5.8 0.3 1.59e-8 Colorectal cancer; CRC trans rs3780486 0.505 rs10758188 chr9:33123386 C/T cg20290983 chr6:43655470 MRPS18A -0.95 -17.8 -0.7 3.9e-50 IgG glycosylation; CRC cis rs6591182 0.504 rs7130955 chr11:65372580 C/T cg27068330 chr11:65405492 SIPA1 -0.52 -7.75 -0.39 1.14e-13 Non-alcoholic fatty liver disease histology (lobular); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg07584320 chr11:94964503 SESN3 0.41 6.57 0.34 1.96e-10 Liver disease severity in Alagille syndrome; CRC cis rs6831352 0.918 rs29001195 chr4:100054244 G/T cg12011299 chr4:100065546 ADH4 -0.49 -9.27 -0.45 2.61e-18 Alcohol dependence; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg14023350 chr14:89631066 FOXN3 0.28 6.72 0.35 8.11e-11 Liver disease severity in Alagille syndrome; CRC cis rs929354 0.742 rs3808316 chr7:156944787 C/G cg05182265 chr7:156933206 UBE3C -0.75 -13.75 -0.6 2.6e-34 Body mass index; CRC trans rs1814175 0.817 rs1988416 chr11:49932324 G/A cg15704280 chr7:45808275 SEPT13 -1.02 -20.57 -0.75 5.09e-61 Height; CRC cis rs6831352 1.000 rs6837685 chr4:100049145 G/A cg12011299 chr4:100065546 ADH4 0.53 10.92 0.52 6.76e-24 Alcohol dependence; CRC cis rs7772486 0.875 rs2814873 chr6:146308932 T/C cg13319975 chr6:146136371 FBXO30 -0.39 -5.87 -0.31 1.08e-8 Lobe attachment (rater-scored or self-reported); CRC cis rs6665290 0.868 rs2183836 chr1:227199404 A/T cg10327440 chr1:227177885 CDC42BPA -1.01 -21.46 -0.76 1.61e-64 Myeloid white cell count; CRC cis rs9341808 0.739 rs4706831 chr6:81007699 T/C cg08355045 chr6:80787529 NA 0.37 6.16 0.32 2.08e-9 Sitting height ratio; CRC cis rs447 1.000 rs7781923 chr7:83747200 T/G cg22846510 chr7:83753280 SEMA3A -0.59 -7.65 -0.39 2.29e-13 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC trans rs561341 1.000 rs484175 chr17:30309041 G/A cg20587970 chr11:113659929 NA -1.43 -20.51 -0.75 8.67e-61 Hip circumference adjusted for BMI; CRC cis rs1983891 1.000 rs9296365 chr6:41535379 A/G cg20194872 chr6:41519635 FOXP4 0.39 5.64 0.3 3.61e-8 Prostate cancer; CRC cis rs9814567 1.000 rs3846055 chr3:134203973 T/A cg06541857 chr3:134203789 ANAPC13;CEP63 -0.41 -6.32 -0.33 8.47e-10 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs1691799 0.867 rs1168343 chr12:66758581 C/T cg16791601 chr12:66731901 HELB -0.73 -12.82 -0.58 8.7e-31 White blood cell count (basophil); CRC cis rs1538970 0.816 rs4633317 chr1:45985157 T/C cg05343316 chr1:45956843 TESK2 0.75 10.02 0.48 8.28e-21 Platelet count; CRC cis rs8017423 0.647 rs4904673 chr14:90817338 G/A cg14092571 chr14:90743983 NA 0.38 5.86 0.31 1.12e-8 Mortality in heart failure; CRC cis rs524281 0.817 rs10896097 chr11:65967953 A/C cg16950941 chr11:66035639 RAB1B -0.58 -7.27 -0.37 2.6e-12 Electroencephalogram traits; CRC cis rs477895 0.713 rs3802933 chr11:63988102 C/T cg18225595 chr11:63971243 STIP1 0.56 7.4 0.38 1.16e-12 Mean platelet volume; CRC cis rs929354 0.772 rs2023975 chr7:157012096 G/A cg17757837 chr7:157058334 UBE3C 0.75 12.7 0.57 2.49e-30 Body mass index; CRC cis rs4268898 1.000 rs4268898 chr2:24490413 C/T cg06627628 chr2:24431161 ITSN2 0.49 7.32 0.37 1.87e-12 Asthma; CRC cis rs57221529 0.709 rs72707024 chr5:667915 G/A cg09021430 chr5:549028 NA -0.57 -6.06 -0.32 3.79e-9 Lung disease severity in cystic fibrosis; CRC cis rs972578 0.791 rs4822243 chr22:43383503 T/C cg01576275 chr22:43409880 NA -0.48 -7.71 -0.39 1.47e-13 Mean platelet volume; CRC cis rs6502050 0.799 rs28376857 chr17:80104351 G/A cg13198984 chr17:80129470 CCDC57 0.46 8.16 0.41 6.94e-15 Life satisfaction; CRC cis rs6088590 0.648 rs6058105 chr20:33271719 C/T cg08999081 chr20:33150536 PIGU 0.59 11.07 0.52 1.99e-24 Coronary artery disease; CRC cis rs11628318 0.802 rs6575926 chr14:103050183 G/A cg08075719 chr14:103021372 NA -0.7 -9.22 -0.45 3.63e-18 Platelet count; CRC cis rs2204008 0.743 rs2132212 chr12:38039405 G/A cg13010199 chr12:38710504 ALG10B 0.5 7.33 0.37 1.85e-12 Bladder cancer; CRC cis rs738322 0.554 rs6001033 chr22:38557513 T/A cg03162506 chr22:38580953 NA 0.28 6.0 0.31 5.31e-9 Cutaneous nevi; CRC cis rs780096 0.506 rs780100 chr2:27652153 G/T cg12000995 chr2:27665139 KRTCAP3 -0.31 -6.54 -0.34 2.37e-10 Total body bone mineral density; CRC cis rs28386778 0.897 rs2584617 chr17:61925298 C/T cg06601766 chr17:61851465 DDX42;CCDC47 0.43 5.86 0.31 1.1e-8 Prudent dietary pattern; CRC cis rs79349575 0.749 rs957557 chr17:47003221 G/T cg00947319 chr17:47005597 UBE2Z -0.35 -5.99 -0.31 5.54e-9 Type 2 diabetes; CRC cis rs736408 0.509 rs3774349 chr3:52722335 A/C cg11645453 chr3:52864694 ITIH4 0.33 6.05 0.32 4.01e-9 Bipolar disorder; CRC cis rs13191362 1.000 rs67025553 chr6:163011552 C/T cg23758597 chr6:163146217 PARK2 -0.56 -6.17 -0.32 2.03e-9 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC trans rs11098499 0.863 rs10013305 chr4:120450424 G/A cg25214090 chr10:38739885 LOC399744 0.65 10.07 0.49 5.96e-21 Corneal astigmatism; CRC cis rs60871478 1.000 rs62432253 chr7:802928 A/G cg13798912 chr7:905769 UNC84A 0.56 6.46 0.34 3.72e-10 Cerebrospinal P-tau181p levels; CRC cis rs12472274 0.646 rs10929269 chr2:239097423 A/G cg17459225 chr2:239074497 NA 0.7 8.23 0.41 4.48e-15 Phospholipid levels (plasma); CRC cis rs875971 0.862 rs10250544 chr7:65766561 A/G cg12463550 chr7:65579703 CRCP -0.49 -6.67 -0.35 1.09e-10 Aortic root size; CRC cis rs10256972 0.721 rs2030959 chr7:1075906 T/C cg16145915 chr7:1198662 ZFAND2A -0.3 -5.87 -0.31 1.04e-8 Longevity;Endometriosis; CRC cis rs9910055 0.530 rs11652651 chr17:42302907 A/G cg10896456 chr17:42255109 ASB16;C17orf65 -0.34 -5.8 -0.3 1.52e-8 Total body bone mineral density; CRC cis rs9325144 0.600 rs6582630 chr12:38743508 A/G cg26384229 chr12:38710491 ALG10B -0.56 -8.18 -0.41 6.3e-15 Morning vs. evening chronotype; CRC cis rs11785400 0.753 rs9773415 chr8:143731170 G/A cg10596483 chr8:143751796 JRK 0.49 6.6 0.34 1.67e-10 Schizophrenia; CRC cis rs1983170 1.000 rs1983170 chr1:91986482 G/A cg02896835 chr1:92012615 NA 0.49 6.33 0.33 8.05e-10 Eosinophil percentage of white cells; CRC cis rs1055129 0.560 rs2608880 chr17:73938957 C/T cg08125733 chr17:73851984 WBP2 0.5 6.64 0.34 1.3e-10 White matter hyperintensity burden; CRC cis rs951366 0.617 rs823080 chr1:205789282 G/A cg17178900 chr1:205818956 PM20D1 0.85 13.79 0.61 1.8e-34 Menarche (age at onset); CRC cis rs10504229 0.562 rs2014516 chr8:58128288 C/A cg22535103 chr8:58192502 C8orf71 -0.7 -9.34 -0.46 1.47e-18 Developmental language disorder (linguistic errors); CRC cis rs7677751 0.747 rs1800809 chr4:55093914 A/G cg17187183 chr4:55093834 PDGFRA 0.52 7.37 0.38 1.36e-12 Corneal astigmatism; CRC cis rs9372498 0.505 rs62424204 chr6:118861642 G/A cg22561889 chr6:118971681 C6orf204 0.51 6.52 0.34 2.72e-10 Diastolic blood pressure; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg06966887 chr5:443603 EXOC3;C5orf55 0.46 6.51 0.34 2.82e-10 Response to antipsychotic treatment; CRC cis rs2204008 0.624 rs2320449 chr12:38224190 T/C cg13010199 chr12:38710504 ALG10B 0.45 5.74 0.3 2.1e-8 Bladder cancer; CRC cis rs9303401 0.632 rs9915267 chr17:57244907 A/G cg02118635 chr17:56770003 RAD51C;TEX14 0.44 6.83 0.35 4.2e-11 Cognitive test performance; CRC cis rs941764 0.965 rs747159 chr14:91841030 A/C cg10511902 chr14:91842949 CCDC88C -0.61 -10.45 -0.5 2.96e-22 Breast cancer; CRC cis rs2227564 0.620 rs11000785 chr10:75575963 T/C cg00564723 chr10:75632066 CAMK2G -0.3 -7.4 -0.38 1.18e-12 Crohn's disease;Inflammatory bowel disease; CRC cis rs6912958 0.559 rs446851 chr6:88043640 G/A cg08069147 chr6:88032118 GJB7;C6orf162 0.7 11.24 0.53 4.88e-25 Monocyte percentage of white cells; CRC cis rs7224737 1.000 rs12603330 chr17:40290589 T/A cg02228675 chr17:40259724 DHX58 -0.48 -6.8 -0.35 5.05e-11 Fibrinogen levels; CRC cis rs7215564 0.908 rs2316063 chr17:78663360 G/A cg09596252 chr17:78655493 RPTOR 0.54 6.08 0.32 3.26e-9 Myopia (pathological); CRC cis rs8180040 0.681 rs9818382 chr3:47193034 C/T cg10298567 chr3:47292165 KIF9 -0.4 -6.25 -0.33 1.3e-9 Colorectal cancer; CRC cis rs9303280 0.776 rs11078926 chr17:38062976 G/A cg20243544 chr17:37824526 PNMT 0.39 5.83 0.31 1.29e-8 Self-reported allergy; CRC cis rs77633900 0.614 rs2468123 chr15:76931345 T/C cg21673338 chr15:77095150 SCAPER -0.77 -8.23 -0.41 4.56e-15 Non-glioblastoma glioma;Glioma; CRC cis rs6570726 0.846 rs6570698 chr6:145918635 C/G cg13319975 chr6:146136371 FBXO30 -0.41 -6.0 -0.31 5.17e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs7487075 0.893 rs2408508 chr12:46730600 T/C cg22049899 chr12:47219821 SLC38A4 0.35 6.82 0.35 4.45e-11 Itch intensity from mosquito bite; CRC cis rs2179367 0.959 rs537354 chr6:149665937 C/T cg11245181 chr6:149772854 ZC3H12D -0.42 -6.3 -0.33 9.3e-10 Dupuytren's disease; CRC cis rs644799 0.710 rs10765771 chr11:95521044 A/G cg25622487 chr11:95524042 FAM76B;CEP57 0.8 13.45 0.6 3.78e-33 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs9611565 0.659 rs73178641 chr22:41952075 A/T cg03806693 chr22:41940476 POLR3H -1.15 -15.58 -0.65 2.2e-41 Vitiligo; CRC trans rs3858526 0.883 rs10769320 chr11:5932831 G/C cg01505111 chr6:125621795 HDDC2 0.38 6.02 0.31 4.68e-9 DNA methylation (variation); CRC cis rs9517320 0.534 rs9554478 chr13:99187792 G/A cg20487152 chr13:99095054 FARP1 -0.46 -6.53 -0.34 2.5e-10 Longevity; CRC cis rs9303280 0.773 rs12949100 chr17:38057189 G/A cg17344932 chr17:38183730 MED24;SNORD124 0.39 6.13 0.32 2.46e-9 Self-reported allergy; CRC cis rs1799949 1.000 rs8176202 chr17:41230228 G/A cg25072359 chr17:41440525 NA 0.43 6.35 0.33 7.25e-10 Menopause (age at onset); CRC cis rs951366 0.789 rs864783 chr1:205711974 T/C cg17178900 chr1:205818956 PM20D1 0.67 9.72 0.47 8.48e-20 Menarche (age at onset); CRC cis rs763014 1.000 rs7205409 chr16:642610 A/G cg02475695 chr16:616220 NHLRC4 0.44 7.44 0.38 8.79e-13 Height; CRC cis rs1633360 1 rs1633360 chr12:58108052 C/T cg18357645 chr12:58087776 OS9 0.52 7.43 0.38 9.71e-13 Rheumatoid arthritis; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg05329982 chr11:62359210 TUT1 0.43 6.01 0.31 4.81e-9 Response to antipsychotic treatment; CRC cis rs853679 0.760 rs2299029 chr6:28198831 G/A cg03623178 chr6:28175578 NA 0.77 8.37 0.42 1.67e-15 Depression; CRC trans rs7937682 0.855 rs10891285 chr11:111527775 T/C cg18187862 chr3:45730750 SACM1L 0.49 7.05 0.36 1.07e-11 Primary sclerosing cholangitis; CRC cis rs1538970 0.816 rs61788356 chr1:46006675 C/T cg05343316 chr1:45956843 TESK2 0.72 9.42 0.46 8e-19 Platelet count; CRC trans rs7267979 1.000 rs6083828 chr20:25369918 T/C cg17903999 chr18:56338584 MALT1 0.42 6.84 0.35 3.84e-11 Liver enzyme levels (alkaline phosphatase); CRC cis rs7666738 0.830 rs13148324 chr4:98833616 G/A cg17366294 chr4:99064904 C4orf37 0.43 6.87 0.35 3.26e-11 Colonoscopy-negative controls vs population controls; CRC cis rs853679 0.517 rs12332979 chr6:28141548 T/G cg18032046 chr6:28092343 ZSCAN16 -0.52 -5.93 -0.31 7.58e-9 Depression; CRC cis rs847577 0.630 rs2132276 chr7:97826340 G/A cg00277769 chr7:97922759 BAIAP2L1 -0.41 -6.88 -0.35 2.99e-11 Breast cancer; CRC cis rs6860806 0.507 rs273915 chr5:131660119 G/C cg27615366 chr5:131592974 PDLIM4 0.32 5.68 0.3 2.98e-8 Breast cancer; CRC cis rs2836974 0.831 rs34294410 chr21:40555160 C/G cg17971929 chr21:40555470 PSMG1 0.83 11.82 0.55 4.02e-27 Cognitive function; CRC cis rs727505 1.000 rs28622327 chr7:124526213 C/T cg23710748 chr7:124431027 NA -0.8 -14.18 -0.62 6.24e-36 Lewy body disease; CRC cis rs9462027 0.628 rs9380455 chr6:34690778 C/A cg07306190 chr6:34760872 UHRF1BP1 0.34 5.97 0.31 6.27e-9 Systemic lupus erythematosus; CRC cis rs3796352 0.667 rs34860124 chr3:52857778 T/A cg06204229 chr3:52865917 ITIH4 0.61 7.13 0.37 6.5e-12 Immune reponse to smallpox (secreted IL-2); CRC cis rs68170813 0.559 rs3823960 chr7:107009349 T/C cg02696742 chr7:106810147 HBP1 -0.57 -6.22 -0.32 1.52e-9 Coronary artery disease; CRC cis rs7523050 0.643 rs7522324 chr1:109399644 T/C cg08274380 chr1:109419600 GPSM2 0.84 6.6 0.34 1.69e-10 Fat distribution (HIV); CRC cis rs1059312 1.000 rs7136092 chr12:129280164 G/C cg09035930 chr12:129282057 SLC15A4 0.54 9.06 0.45 1.19e-17 Systemic lupus erythematosus; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg11105585 chr21:45759228 C21orf2 0.4 6.29 0.33 1.01e-9 Liver disease severity in Alagille syndrome; CRC cis rs950169 1.000 rs1848093 chr15:84755527 G/C cg03959625 chr15:84868606 LOC388152 0.41 6.07 0.32 3.55e-9 Schizophrenia; CRC cis rs7216064 1.000 rs9912084 chr17:65868035 A/C cg12091567 chr17:66097778 LOC651250 -0.62 -7.85 -0.4 6.07e-14 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CRC cis rs10197940 0.578 rs2444264 chr2:152310928 G/T cg06191203 chr2:152266755 RIF1 0.43 6.12 0.32 2.68e-9 Lung cancer; CRC cis rs4332037 0.722 rs60346318 chr7:1915824 C/G cg24505167 chr7:1915268 MAD1L1 -0.49 -7.44 -0.38 8.84e-13 Bipolar disorder; CRC cis rs1577917 1.000 rs12207305 chr6:86723502 A/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.53 -6.9 -0.36 2.63e-11 Response to antipsychotic treatment; CRC cis rs4862750 0.872 rs6825289 chr4:187879109 T/G cg10295955 chr4:187884368 NA -1.03 -26.25 -0.82 1.1e-82 Lobe attachment (rater-scored or self-reported); CRC cis rs10499694 0.933 rs12718583 chr7:50582631 T/C cg14593290 chr7:50529359 DDC -0.43 -6.25 -0.33 1.29e-9 Body mass index; CRC cis rs875971 0.545 rs4718348 chr7:65906576 A/G cg05627663 chr7:65219948 SNORA22;CCT6P1 0.53 6.7 0.35 9.04e-11 Aortic root size; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg06797938 chr17:1466136 PITPNA 0.41 6.25 0.33 1.29e-9 Liver disease severity in Alagille syndrome; CRC cis rs17021463 0.872 rs10856909 chr4:95268748 C/G cg11021082 chr4:95130006 SMARCAD1 0.44 6.61 0.34 1.55e-10 Testicular germ cell tumor; CRC trans rs2797160 1.000 rs1739378 chr6:126012262 C/A cg05039488 chr6:79577232 IRAK1BP1 0.51 7.6 0.39 3.09e-13 Endometrial cancer; CRC cis rs9291683 0.620 rs11722946 chr4:10125990 A/G cg00071950 chr4:10020882 SLC2A9 -0.48 -8.16 -0.41 7.01e-15 Bone mineral density; CRC trans rs2303319 0.504 rs1006428 chr2:162592559 A/C cg23919916 chr10:103825097 HPS6 -0.69 -6.01 -0.31 4.8e-9 Cognitive function; CRC cis rs11577318 0.853 rs2276712 chr1:26627478 T/C cg04990556 chr1:26633338 UBXN11 -0.49 -6.25 -0.33 1.3e-9 Granulocyte percentage of myeloid white cells; CRC cis rs7917772 0.636 rs7911747 chr10:104528890 A/G cg04362960 chr10:104952993 NT5C2 0.46 6.11 0.32 2.84e-9 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC cis rs6912958 0.935 rs2179844 chr6:88165773 C/A cg12350822 chr6:88032061 C6orf162;GJB7 -0.36 -6.94 -0.36 2.13e-11 Monocyte percentage of white cells; CRC cis rs12541635 0.677 rs55639043 chr8:107055993 C/T cg10147462 chr8:107024639 NA 0.62 11.23 0.53 5.35e-25 Age of smoking initiation; CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg16522107 chr15:65579214 PARP16 0.38 6.15 0.32 2.18e-9 Obesity-related traits; CRC cis rs12681287 0.640 rs6992287 chr8:87418960 G/A cg27223183 chr8:87520930 FAM82B 0.51 6.96 0.36 1.87e-11 Caudate activity during reward; CRC cis rs208515 0.525 rs12215007 chr6:66671008 C/T cg07460842 chr6:66804631 NA -0.96 -12.27 -0.56 9.23e-29 Exhaled nitric oxide levels; CRC cis rs6502050 0.698 rs6502076 chr17:80121978 A/G cg22110888 chr17:80059540 CCDC57 0.4 6.38 0.33 5.96e-10 Life satisfaction; CRC cis rs2777491 0.957 rs3743038 chr15:41694743 C/T cg18705301 chr15:41695430 NDUFAF1 -0.73 -12.39 -0.56 3.46e-29 Ulcerative colitis; CRC trans rs2014572 0.967 rs10411941 chr19:57762886 C/T cg02674126 chr19:40336878 FBL 0.42 6.74 0.35 6.98e-11 Hyperactive-impulsive symptoms; CRC trans rs2303319 0.504 rs35304298 chr2:162617185 G/T cg23247704 chr1:116518985 SLC22A15 -0.72 -6.12 -0.32 2.7e-9 Cognitive function; CRC cis rs294883 0.739 rs962340 chr6:159729096 C/T cg14500486 chr6:159655392 FNDC1 -0.36 -6.19 -0.32 1.81e-9 Coronary artery disease; CRC cis rs9649213 0.593 rs1132971 chr7:97921533 A/G cg00277769 chr7:97922759 BAIAP2L1 -0.61 -10.79 -0.51 1.87e-23 Prostate cancer (SNP x SNP interaction); CRC trans rs2710642 0.815 rs6545971 chr2:63074986 A/T cg05376469 chr2:102649931 NA -0.36 -5.97 -0.31 6.05e-9 LDL cholesterol levels;LDL cholesterol; CRC cis rs8180040 0.676 rs7633698 chr3:47013452 A/T cg27129171 chr3:47204927 SETD2 0.65 10.3 0.49 9.6e-22 Colorectal cancer; CRC cis rs644799 0.710 rs3017756 chr11:95537358 G/A cg03916912 chr11:95522834 CEP57;FAM76B 0.85 15.75 0.66 4.84e-42 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs1862618 0.627 rs744023 chr5:56197078 C/T cg12311346 chr5:56204834 C5orf35 -0.99 -12.34 -0.56 5.32e-29 Initial pursuit acceleration; CRC cis rs9858542 0.537 rs34514189 chr3:49373045 A/G cg00383909 chr3:49044727 WDR6 0.69 7.1 0.36 7.97e-12 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs10493773 0.609 rs11161651 chr1:86177816 A/G cg17807903 chr1:86174739 ZNHIT6 -0.62 -17.0 -0.68 5.73e-47 Urate levels in overweight individuals; CRC cis rs672059 0.934 rs6703054 chr1:183155778 A/C ch.1.3577855R chr1:183094577 LAMC1 0.51 7.38 0.38 1.29e-12 Hypertriglyceridemia; CRC cis rs881375 0.967 rs10739579 chr9:123694788 C/A cg09419670 chr9:123605666 PSMD5;LOC253039 0.57 8.48 0.42 7.73e-16 Rheumatoid arthritis; CRC cis rs2836974 0.644 rs2836982 chr21:40689171 C/A cg11890956 chr21:40555474 PSMG1 -0.81 -12.8 -0.58 1.02e-30 Cognitive function; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg17592812 chr19:16296137 FAM32A 0.43 6.3 0.33 9.57e-10 Intelligence (multi-trait analysis); CRC cis rs7552404 0.628 rs4949686 chr1:76473299 G/C cg03433033 chr1:76189801 ACADM 0.66 7.59 0.39 3.24e-13 Blood metabolite levels;Acylcarnitine levels; CRC cis rs853679 0.517 rs9368557 chr6:28131537 T/C cg23161317 chr6:28129485 ZNF389 0.53 6.43 0.33 4.52e-10 Depression; CRC cis rs6500395 0.962 rs9924483 chr16:48646258 C/T cg04672837 chr16:48644449 N4BP1 0.42 5.83 0.31 1.31e-8 Response to tocilizumab in rheumatoid arthritis; CRC cis rs6952808 0.630 rs4719443 chr7:2161099 A/G cg04267008 chr7:1944627 MAD1L1 -0.71 -9.89 -0.48 2.3e-20 Bipolar disorder and schizophrenia; CRC cis rs4481887 0.893 rs10736379 chr1:248455876 A/T cg13385794 chr1:248469461 NA 0.37 6.53 0.34 2.55e-10 Common traits (Other); CRC cis rs2115536 1.000 rs11637477 chr15:80193295 C/T cg00225070 chr15:80189496 MTHFS 0.53 8.57 0.43 4.03e-16 Eosinophil counts;Eosinophil percentage of white cells;Sum eosinophil basophil counts;Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; CRC cis rs875971 0.964 rs6978429 chr7:65959876 T/G cg12463550 chr7:65579703 CRCP 0.47 6.79 0.35 5.17e-11 Aortic root size; CRC cis rs736801 0.780 rs2188962 chr5:131770805 C/T cg07395648 chr5:131743802 NA -0.41 -5.96 -0.31 6.36e-9 Breast cancer;Mosquito bite size; CRC cis rs2522056 1.000 rs2706383 chr5:131792402 G/A cg24060327 chr5:131705240 SLC22A5 0.39 5.61 0.3 4.4e-8 Lymphocyte counts;Fibrinogen; CRC cis rs875971 0.545 rs313828 chr7:65552614 T/C cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.6 -7.49 -0.38 6.26e-13 Aortic root size; CRC cis rs10857712 0.703 rs1056521 chr10:135235890 T/C cg17796960 chr10:135278976 LOC619207 -0.37 -5.65 -0.3 3.53e-8 Systemic lupus erythematosus; CRC cis rs6912958 0.874 rs2103764 chr6:88157392 T/A cg08069147 chr6:88032118 GJB7;C6orf162 -0.63 -9.61 -0.47 1.99e-19 Monocyte percentage of white cells; CRC cis rs9814567 0.806 rs4955534 chr3:134319723 T/A cg06541857 chr3:134203789 ANAPC13;CEP63 -0.37 -5.73 -0.3 2.3e-8 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs6502050 0.835 rs6502067 chr17:80111205 A/G cg13198984 chr17:80129470 CCDC57 0.46 8.16 0.41 6.94e-15 Life satisfaction; CRC cis rs7618915 0.570 rs2336145 chr3:52629750 A/C cg07507251 chr3:52567010 NT5DC2 0.46 6.6 0.34 1.67e-10 Bipolar disorder; CRC cis rs75920871 0.528 rs11216244 chr11:116912730 C/T cg01368799 chr11:117014884 PAFAH1B2 -0.4 -5.72 -0.3 2.43e-8 Subjective well-being; CRC cis rs7914558 1.000 rs10748838 chr10:104943986 T/A cg15744005 chr10:104629667 AS3MT -0.34 -7.2 -0.37 4.18e-12 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs6499255 1.000 rs11641521 chr16:69823081 C/G cg15192750 chr16:69999425 NA 0.56 7.22 0.37 3.54e-12 IgE levels; CRC cis rs644799 0.544 rs687559 chr11:95598629 C/T cg03916912 chr11:95522834 CEP57;FAM76B -0.64 -10.49 -0.5 2.13e-22 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs3820068 0.603 rs72645900 chr1:15931980 A/T cg13390004 chr1:15929781 NA 0.49 6.98 0.36 1.64e-11 Systolic blood pressure; CRC cis rs10540 1.000 rs61876326 chr11:467368 A/G cg08200582 chr11:442649 ANO9 -0.69 -7.21 -0.37 3.75e-12 Body mass index; CRC trans rs453301 0.571 rs330048 chr8:9087278 A/C cg16141378 chr3:129829833 LOC729375 0.41 6.11 0.32 2.78e-9 Joint mobility (Beighton score); CRC trans rs561341 1.000 rs554078 chr17:30330109 A/C cg27661571 chr11:113659931 NA -0.96 -11.08 -0.52 1.89e-24 Hip circumference adjusted for BMI; CRC cis rs394563 0.690 rs237009 chr6:149759552 C/T cg17885791 chr6:149771845 ZC3H12D -0.33 -5.84 -0.31 1.25e-8 Dupuytren's disease; CRC cis rs7927771 0.864 rs112060627 chr11:47426956 G/A cg20307385 chr11:47447363 PSMC3 -0.63 -9.2 -0.45 4.33e-18 Subjective well-being; CRC cis rs7618915 0.524 rs10433615 chr3:52638482 C/T cg18099408 chr3:52552593 STAB1 -0.44 -7.27 -0.37 2.7e-12 Bipolar disorder; CRC cis rs67311347 1.000 rs12492035 chr3:40467110 G/A cg09455208 chr3:40491958 NA 0.5 10.04 0.48 7.46e-21 Renal cell carcinoma; CRC cis rs6942756 1.000 rs11763056 chr7:128960871 C/A cg02491457 chr7:128862824 NA -0.76 -10.25 -0.49 1.46e-21 White matter hyperintensity burden; CRC cis rs9467711 0.606 rs2072806 chr6:26385093 C/G cg08501292 chr6:25962987 TRIM38 0.84 6.5 0.34 2.92e-10 Autism spectrum disorder or schizophrenia; CRC cis rs1218582 0.774 rs4845681 chr1:154868055 G/T cg09359103 chr1:154839909 KCNN3 -0.68 -11.78 -0.54 5.76e-27 Prostate cancer; CRC cis rs73198271 0.562 rs17698256 chr8:8659613 C/T cg01851573 chr8:8652454 MFHAS1 0.48 6.19 0.32 1.75e-9 Bone ultrasound measurement (broadband ultrasound attenuation); CRC cis rs769267 0.965 rs2965198 chr19:19473030 A/G cg02546618 chr19:19431379 KIAA0892;SF4 -0.48 -6.59 -0.34 1.72e-10 Tonsillectomy; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg05318427 chr2:85199320 KCMF1 0.52 7.55 0.38 4.3e-13 Response to antipsychotic treatment; CRC cis rs6951245 0.882 rs10256720 chr7:1210825 C/G cg18402987 chr7:1209562 NA 0.8 9.25 0.45 2.96e-18 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs34172651 0.617 rs9922436 chr16:24704490 C/G cg00339695 chr16:24857497 SLC5A11 0.35 7.17 0.37 4.91e-12 Intelligence (multi-trait analysis); CRC cis rs10865541 0.902 rs12476309 chr2:3404845 C/T cg22182287 chr2:3452347 TTC15 0.37 5.95 0.31 6.72e-9 Obesity-related traits; CRC cis rs28386778 0.831 rs2584618 chr17:61923611 T/C cg11494091 chr17:61959527 GH2 0.63 10.87 0.51 1.04e-23 Prudent dietary pattern; CRC cis rs1200821 0.529 rs2505707 chr10:37801254 T/C cg25427524 chr10:38739819 LOC399744 -0.59 -9.54 -0.47 3.23e-19 Hemostatic factors and hematological phenotypes; CRC trans rs12940923 1.000 rs11868285 chr17:56371181 C/T cg16900910 chr15:72789182 ARIH1 0.52 5.97 0.31 6.14e-9 Circulating myeloperoxidase levels (plasma); CRC cis rs875971 1.000 rs1540651 chr7:65650121 C/T cg12463550 chr7:65579703 CRCP -0.5 -7.26 -0.37 2.87e-12 Aortic root size; CRC cis rs459482 1.000 rs459498 chr21:42795027 G/A cg14166395 chr21:42792516 MX1 0.51 7.06 0.36 9.9e-12 IgG glycosylation; CRC cis rs10504229 0.593 rs12155520 chr8:58014318 C/T cg20607798 chr8:58055168 NA 0.5 5.78 0.3 1.75e-8 Developmental language disorder (linguistic errors); CRC trans rs7267979 0.966 rs2387882 chr20:25378802 C/T cg17903999 chr18:56338584 MALT1 0.42 6.98 0.36 1.65e-11 Liver enzyme levels (alkaline phosphatase); CRC cis rs2197308 0.659 rs11181327 chr12:37903171 C/T cg26384229 chr12:38710491 ALG10B -0.63 -9.63 -0.47 1.65e-19 Morning vs. evening chronotype; CRC cis rs72615157 0.664 rs6953580 chr7:99825275 A/G cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.46 5.88 0.31 1.02e-8 Lung function (FEV1/FVC); CRC trans rs9388451 0.839 rs3799711 chr6:126075313 C/T cg05039488 chr6:79577232 IRAK1BP1 0.56 8.48 0.42 7.7e-16 Brugada syndrome; CRC cis rs4423214 0.840 rs2017686 chr11:71187061 C/G cg13043300 chr11:71146211 DHCR7 -0.44 -5.98 -0.31 5.98e-9 Vitamin D levels; CRC cis rs910316 1.000 rs910316 chr14:75626042 A/C cg11812906 chr14:75593930 NEK9 0.65 10.22 0.49 1.83e-21 Height; CRC cis rs11587400 0.679 rs6537834 chr1:115108870 T/C cg12756093 chr1:115239321 AMPD1 0.43 5.9 0.31 9.27e-9 Autism; CRC cis rs853679 0.517 rs9368554 chr6:28082711 T/C cg12963246 chr6:28129442 ZNF389 0.5 5.8 0.3 1.53e-8 Depression; CRC cis rs1552244 0.882 rs68153882 chr3:10013110 T/C cg08888203 chr3:10149979 C3orf24 0.62 8.32 0.42 2.36e-15 Alzheimer's disease; CRC trans rs57221529 0.766 rs12522303 chr5:555564 A/C cg25482853 chr8:67687455 SGK3 1.25 15.72 0.65 6.58e-42 Lung disease severity in cystic fibrosis; CRC trans rs208520 0.690 rs207091 chr6:66799847 G/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.07 -15.42 -0.65 9.24e-41 Exhaled nitric oxide output; CRC cis rs6088590 0.561 rs6087605 chr20:33180624 G/T cg08999081 chr20:33150536 PIGU 0.65 12.57 0.57 7.42e-30 Coronary artery disease; CRC cis rs4594175 0.886 rs11157802 chr14:51622984 C/T cg23942311 chr14:51606299 NA 0.66 10.88 0.51 9.1e-24 Cancer; CRC cis rs7927771 0.832 rs10838698 chr11:47385923 G/A cg18512352 chr11:47633146 NA 0.35 6.88 0.35 2.96e-11 Subjective well-being; CRC cis rs875971 0.508 rs10242423 chr7:66059175 A/G cg00343986 chr7:65444356 GUSB -0.47 -7.07 -0.36 9.5e-12 Aortic root size; CRC cis rs9322193 0.923 rs9688517 chr6:150061791 T/C cg07701084 chr6:150067640 NUP43 0.61 9.13 0.45 7.29e-18 Lung cancer; CRC cis rs67311347 1.000 rs12494022 chr3:40426652 A/C cg24209194 chr3:40518798 ZNF619 0.41 5.6 0.3 4.46e-8 Renal cell carcinoma; CRC cis rs7927771 0.965 rs12787112 chr11:47687147 A/G cg20307385 chr11:47447363 PSMC3 -0.52 -7.12 -0.37 6.8e-12 Subjective well-being; CRC cis rs4862750 0.914 rs11945845 chr4:187874136 T/C cg27532560 chr4:187881888 NA -0.54 -9.87 -0.48 2.69e-20 Lobe attachment (rater-scored or self-reported); CRC cis rs4713118 0.662 rs9468275 chr6:28026136 G/T cg21251018 chr6:28226885 NKAPL 0.46 6.46 0.34 3.67e-10 Parkinson's disease; CRC trans rs1814175 0.817 rs80244685 chr11:49763292 C/A cg21153622 chr11:89784906 NA -0.39 -5.97 -0.31 6.21e-9 Height; CRC cis rs1005277 0.579 rs2505240 chr10:38442419 G/T cg25517755 chr10:38738941 LOC399744 -0.42 -6.1 -0.32 3.03e-9 Extrinsic epigenetic age acceleration; CRC cis rs612683 0.518 rs10875287 chr1:100812908 T/C cg06223162 chr1:101003688 GPR88 -0.32 -5.66 -0.3 3.25e-8 Breast cancer; CRC cis rs35110281 0.633 rs4818860 chr21:45119617 C/T cg04455712 chr21:45112962 RRP1B 0.42 8.09 0.41 1.16e-14 Mean corpuscular volume; CRC cis rs10791323 0.593 rs2282604 chr11:133714672 A/G cg15485101 chr11:133734466 NA 0.45 7.79 0.39 8.96e-14 Childhood ear infection; CRC cis rs7618915 0.547 rs13064064 chr3:52657002 T/C cg05573699 chr3:52720067 GNL3;PBRM1 -0.46 -6.59 -0.34 1.76e-10 Bipolar disorder; CRC cis rs2032447 0.966 rs3752416 chr6:26045929 T/C cg03517284 chr6:25882590 NA -0.45 -6.31 -0.33 8.79e-10 Intelligence (multi-trait analysis); CRC cis rs9921222 0.521 rs757460 chr16:367174 G/C cg08923669 chr16:420230 MRPL28 -0.49 -6.29 -0.33 1.01e-9 Bone mineral density (spine);Bone mineral density; CRC cis rs7618915 0.571 rs12632381 chr3:52607685 G/A cg15147215 chr3:52552868 STAB1 -0.63 -10.56 -0.5 1.18e-22 Bipolar disorder; CRC cis rs75804782 0.641 rs72987304 chr2:239345532 C/T cg18131467 chr2:239335373 ASB1 -0.71 -6.28 -0.33 1.06e-9 Morning vs. evening chronotype;Chronotype; CRC cis rs7208859 0.623 rs58908911 chr17:29244558 C/T cg13385521 chr17:29058706 SUZ12P 0.68 7.91 0.4 4.06e-14 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs4363385 0.510 rs11576797 chr1:153049417 T/C cg25856811 chr1:152973957 SPRR3 -0.21 -5.62 -0.3 4.03e-8 Inflammatory skin disease; CRC cis rs9814567 0.762 rs13071253 chr3:134316653 C/T cg06109529 chr3:134205091 CEP63;ANAPC13 0.68 9.01 0.44 1.72e-17 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs644799 0.648 rs1255176 chr11:95471465 A/T cg03916912 chr11:95522834 CEP57;FAM76B 0.56 8.89 0.44 4.24e-17 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs11229555 0.645 rs7117080 chr11:58178677 C/G cg15696309 chr11:58395628 NA -0.73 -9.67 -0.47 1.27e-19 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; CRC cis rs2882667 0.754 rs11746434 chr5:138435303 A/G cg04439458 chr5:138467593 SIL1 -0.36 -6.02 -0.32 4.62e-9 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs7095944 0.585 rs7080838 chr10:126419841 A/G cg08799069 chr10:126477246 METTL10 0.46 7.17 0.37 4.83e-12 Asthma; CRC cis rs2281845 0.507 rs7547762 chr1:201088245 A/G cg08885800 chr1:201084119 NA 0.42 6.06 0.32 3.64e-9 Permanent tooth development; CRC cis rs9322193 0.923 rs4869812 chr6:149990583 A/G cg13206674 chr6:150067644 NUP43 0.64 9.58 0.47 2.48e-19 Lung cancer; CRC cis rs4665809 0.627 rs13014338 chr2:26463024 C/T cg25036284 chr2:26402008 FAM59B 0.61 7.76 0.39 1.09e-13 Gut microbiome composition (summer); CRC cis rs853679 0.517 rs9368557 chr6:28131537 T/C cg02683197 chr6:28174875 NA 0.87 10.73 0.51 3.25e-23 Depression; CRC cis rs2276314 0.857 rs28396546 chr18:33639024 T/C cg05985134 chr18:33552581 C18orf21 0.5 6.79 0.35 5.24e-11 Endometriosis;Drug-induced torsades de pointes; CRC cis rs1570884 0.556 rs2146146 chr13:50170368 C/T cg08779649 chr13:50194554 NA 0.43 8.96 0.44 2.46e-17 Sum basophil neutrophil counts;Sum neutrophil eosinophil counts;Neutrophil count;Myeloid white cell count;Granulocyte count; CRC cis rs881375 0.678 rs9886724 chr9:123665019 A/G cg09586646 chr9:123605570 PSMD5;LOC253039 0.46 6.84 0.35 3.88e-11 Rheumatoid arthritis; CRC cis rs10256972 0.504 rs2949178 chr7:1209925 T/C cg09177884 chr7:1199841 ZFAND2A -0.56 -8.52 -0.43 5.72e-16 Longevity;Endometriosis; CRC cis rs1552244 0.882 rs55962400 chr3:10044457 C/T cg02579736 chr3:10068473 FANCD2;CIDECP 0.93 11.05 0.52 2.44e-24 Alzheimer's disease; CRC cis rs769267 0.501 rs2965187 chr19:19522970 T/A cg03709012 chr19:19516395 GATAD2A 0.52 5.62 0.3 4.16e-8 Tonsillectomy; CRC cis rs2303759 0.626 rs12982246 chr19:49801169 A/G cg22133161 chr19:49891603 CCDC155 0.48 6.3 0.33 9.42e-10 Multiple sclerosis; CRC cis rs6840360 0.615 rs6858483 chr4:152465509 C/T cg09659197 chr4:152720779 NA 0.31 5.64 0.3 3.6e-8 Intelligence (multi-trait analysis); CRC cis rs9322193 0.962 rs3805753 chr6:150116798 C/T cg13206674 chr6:150067644 NUP43 0.57 8.14 0.41 8.29e-15 Lung cancer; CRC cis rs274567 0.550 rs272885 chr5:131667736 A/G cg24060327 chr5:131705240 SLC22A5 -0.51 -7.62 -0.39 2.71e-13 Blood metabolite levels; CRC cis rs1865760 0.622 rs9295685 chr6:26071725 G/C cg17691542 chr6:26056736 HIST1H1C 0.56 8.59 0.43 3.66e-16 Height; CRC cis rs2204008 0.806 rs3922574 chr12:38329069 C/T cg13010199 chr12:38710504 ALG10B 0.45 6.01 0.31 5.04e-9 Bladder cancer; CRC cis rs6582630 0.560 rs4882325 chr12:38510037 C/T cg13010199 chr12:38710504 ALG10B -0.43 -6.25 -0.33 1.28e-9 Drug-induced liver injury (flucloxacillin); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg01498160 chr12:26348463 SSPN 0.38 6.06 0.32 3.74e-9 Intelligence (multi-trait analysis); CRC cis rs1348850 0.914 rs4893957 chr2:178380409 A/G cg02961200 chr2:178257176 LOC100130691;AGPS 0.6 8.62 0.43 2.93e-16 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs7726839 0.794 rs10474792 chr5:600058 G/A cg09021430 chr5:549028 NA -0.66 -8.65 -0.43 2.25e-16 Obesity-related traits; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg06795559 chr20:5931181 MCM8;TRMT6 0.38 6.4 0.33 5.23e-10 Liver disease severity in Alagille syndrome; CRC cis rs9359856 0.564 rs3818133 chr6:90374456 A/G cg13799429 chr6:90582589 CASP8AP2 -0.73 -7.32 -0.37 1.89e-12 Bipolar disorder; CRC cis rs4290604 0.748 rs62183341 chr2:237973410 G/C cg23555395 chr2:238036564 NA 0.61 6.08 0.32 3.32e-9 Asthma; CRC cis rs2842992 0.724 rs9365097 chr6:160211259 G/A cg19482086 chr6:160211437 TCP1;MRPL18 0.82 13.34 0.59 9.27e-33 Age-related macular degeneration (geographic atrophy); CRC cis rs7811142 0.830 rs6965458 chr7:99973402 G/A cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.71 8.96 0.44 2.38e-17 Platelet count; CRC cis rs13253111 1.000 rs13253111 chr8:28061974 C/T cg26534493 chr8:28060551 NA -0.47 -8.31 -0.42 2.56e-15 Childhood body mass index; CRC cis rs910316 0.967 rs175502 chr14:75533679 A/G cg03030879 chr14:75389066 RPS6KL1 0.45 7.1 0.36 7.5e-12 Height; CRC cis rs77633900 0.614 rs279997 chr15:76949262 T/C cg21673338 chr15:77095150 SCAPER -0.77 -8.27 -0.41 3.46e-15 Non-glioblastoma glioma;Glioma; CRC cis rs6460942 0.514 rs118124486 chr7:12470381 T/G cg06484146 chr7:12443880 VWDE -0.48 -6.93 -0.36 2.19e-11 Coronary artery disease; CRC cis rs4665809 0.590 rs3806514 chr2:26466772 C/T cg08067268 chr2:26466485 HADHB;HADHA 0.64 8.33 0.42 2.17e-15 Gut microbiome composition (summer); CRC cis rs11148252 1.000 rs4886018 chr13:52990717 C/T cg12458913 chr13:53173898 NA 0.51 8.22 0.41 4.68e-15 Lewy body disease; CRC cis rs13315871 0.929 rs13080508 chr3:58300116 G/A cg20936604 chr3:58311152 NA -0.71 -7.49 -0.38 6.33e-13 Cholesterol, total; CRC cis rs6582630 0.533 rs11504406 chr12:38334580 C/T cg26384229 chr12:38710491 ALG10B -0.52 -7.49 -0.38 6.29e-13 Drug-induced liver injury (flucloxacillin); CRC cis rs514406 0.505 rs416968 chr1:53183513 A/G cg24675658 chr1:53192096 ZYG11B -0.59 -8.99 -0.44 1.97e-17 Monocyte count; CRC cis rs10256972 0.706 rs12701969 chr7:1121849 A/G cg23978390 chr7:1156363 C7orf50 0.52 6.99 0.36 1.49e-11 Longevity;Endometriosis; CRC cis rs9916302 0.768 rs11078900 chr17:37614641 C/T cg15445000 chr17:37608096 MED1 0.42 9.22 0.45 3.78e-18 Glomerular filtration rate (creatinine); CRC cis rs2011503 0.941 rs11670775 chr19:19649636 A/G cg11584989 chr19:19387371 SF4 0.58 6.39 0.33 5.61e-10 Bipolar disorder; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg24480577 chr20:62169334 PTK6 0.41 6.56 0.34 2.05e-10 Liver disease severity in Alagille syndrome; CRC trans rs72766638 1.000 rs72766638 chr9:136931778 C/A cg09836344 chr4:1243392 C4orf42;CTBP1 -0.61 -6.54 -0.34 2.33e-10 Mosquito bite size; CRC cis rs875971 0.862 rs10240949 chr7:65804417 A/G cg11764359 chr7:65958608 NA -0.61 -9.44 -0.46 6.9e-19 Aortic root size; CRC cis rs9326248 0.520 rs6589602 chr11:117037065 T/C cg11861562 chr11:117069780 TAGLN 0.31 6.9 0.36 2.74e-11 Blood protein levels; CRC trans rs11098499 0.738 rs34566984 chr4:120361270 G/A cg25214090 chr10:38739885 LOC399744 0.66 10.47 0.5 2.41e-22 Corneal astigmatism; CRC cis rs2243480 1.000 rs402418 chr7:65509469 G/A cg12463550 chr7:65579703 CRCP 0.75 6.82 0.35 4.5e-11 Diabetic kidney disease; CRC cis rs3858526 0.606 rs10838883 chr11:5952147 G/A cg25319279 chr11:5960081 NA 0.36 6.39 0.33 5.8e-10 DNA methylation (variation); CRC cis rs2404602 0.716 rs1946650 chr15:76848463 T/C cg03037974 chr15:76606532 NA 0.71 12.66 0.57 3.3e-30 Blood metabolite levels; CRC cis rs6840360 0.515 rs11099811 chr4:152320532 C/A cg09659197 chr4:152720779 NA 0.3 5.66 0.3 3.28e-8 Intelligence (multi-trait analysis); CRC cis rs11785693 0.862 rs11778306 chr8:4988269 A/C cg26367366 chr8:4980734 NA 0.8 9.95 0.48 1.45e-20 Neuroticism (multi-trait analysis);Neuroticism; CRC cis rs12024301 0.557 rs11811536 chr1:183604258 C/A cg11505048 chr1:183622726 RGL1;APOBEC4 0.77 6.87 0.35 3.26e-11 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs6952808 0.717 rs12534679 chr7:1926745 G/A cg04267008 chr7:1944627 MAD1L1 -0.58 -8.86 -0.44 5.25e-17 Bipolar disorder and schizophrenia; CRC cis rs2243480 0.615 rs34363376 chr7:65939536 T/C cg18252515 chr7:66147081 NA -1.27 -14.62 -0.63 1.2e-37 Diabetic kidney disease; CRC cis rs9325144 0.671 rs7486919 chr12:38767997 A/G cg26384229 chr12:38710491 ALG10B -0.51 -7.46 -0.38 7.89e-13 Morning vs. evening chronotype; CRC cis rs244731 1.000 rs244731 chr5:176539679 C/T cg16006841 chr5:176797999 RGS14 0.61 8.3 0.42 2.66e-15 Urate levels in lean individuals; CRC cis rs907683 0.584 rs12991025 chr2:220284779 C/T cg15015639 chr2:220282977 DES 0.44 7.03 0.36 1.18e-11 Resting heart rate; CRC cis rs9322193 0.962 rs9322223 chr6:150122645 G/A cg13206674 chr6:150067644 NUP43 0.53 7.59 0.39 3.32e-13 Lung cancer; CRC cis rs9534288 0.783 rs7987385 chr13:46634131 A/G cg15192986 chr13:46630673 CPB2 -0.78 -10.96 -0.52 5.02e-24 Blood protein levels; CRC cis rs10504229 0.906 rs58559296 chr8:58171714 T/C cg02725872 chr8:58115012 NA -0.38 -6.43 -0.33 4.44e-10 Developmental language disorder (linguistic errors); CRC cis rs3617 0.625 rs2336558 chr3:52886240 C/T cg15147215 chr3:52552868 STAB1 0.53 9.14 0.45 6.62e-18 Red blood cell count;Autism spectrum disorder or schizophrenia; CRC cis rs589448 0.538 rs683790 chr12:69751434 T/G cg20891283 chr12:69753455 YEATS4 0.71 9.97 0.48 1.22e-20 Cerebrospinal fluid biomarker levels; CRC cis rs6752107 0.846 rs7559194 chr2:234206799 G/A cg07618928 chr2:234183455 ATG16L1;SCARNA5 0.59 9.71 0.47 9.45e-20 Crohn's disease;Inflammatory bowel disease; CRC cis rs3751196 0.808 rs17034650 chr12:104219550 G/A cg02344784 chr12:104178138 NT5DC3 0.71 7.25 0.37 3.05e-12 Sense of smell; CRC cis rs6586163 0.872 rs1926201 chr10:90746360 G/C cg03111039 chr10:90751583 FAS;ACTA2 -0.5 -7.13 -0.37 6.43e-12 Chronic lymphocytic leukemia; CRC cis rs11690935 0.798 rs13018768 chr2:172598592 A/G cg13550731 chr2:172543902 DYNC1I2 -1.09 -18.38 -0.71 2.03e-52 Schizophrenia; CRC cis rs9399135 0.967 rs45544135 chr6:135324051 T/C cg22676075 chr6:135203613 NA 0.42 6.51 0.34 2.78e-10 Red blood cell count; CRC cis rs1355223 0.833 rs286885 chr11:34687346 G/T cg11058730 chr11:34937778 PDHX;APIP 0.41 5.66 0.3 3.36e-8 Systemic lupus erythematosus and Systemic sclerosis; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg25944898 chr11:64085532 PRDX5;TRMT112 0.36 6.05 0.32 3.84e-9 Liver disease severity in Alagille syndrome; CRC cis rs875971 0.862 rs6959268 chr7:65812966 G/A cg18252515 chr7:66147081 NA 0.4 5.79 0.3 1.63e-8 Aortic root size; CRC cis rs2032447 0.714 rs199726 chr6:25953360 G/A cg26028573 chr6:26043587 HIST1H2BB 0.42 6.26 0.33 1.2e-9 Intelligence (multi-trait analysis); CRC cis rs10540 0.915 rs12419209 chr11:494510 T/C cg03934478 chr11:495069 RNH1 0.69 7.73 0.39 1.28e-13 Body mass index; CRC cis rs6942756 1.000 rs12111832 chr7:128889025 G/C cg02491457 chr7:128862824 NA -0.76 -10.24 -0.49 1.56e-21 White matter hyperintensity burden; CRC trans rs264943 0.600 rs11675977 chr2:104095893 G/A cg24033067 chr14:24674799 TSSK4 -0.41 -6.01 -0.31 4.8e-9 HIV-1 viral setpoint; CRC cis rs11038871 0.815 rs6485686 chr11:46657430 T/G cg16389345 chr11:46697382 NA 0.35 5.65 0.3 3.49e-8 Immunoglobulin A; CRC cis rs4566357 0.595 rs1320406 chr2:227920474 C/T cg11843606 chr2:227700838 RHBDD1 -0.42 -6.46 -0.34 3.74e-10 Coronary artery disease; CRC cis rs739401 0.611 rs391188 chr11:3047634 G/A cg25174290 chr11:3078921 CARS 0.45 6.84 0.35 3.82e-11 Longevity; CRC cis rs7914558 0.902 rs3736922 chr10:104850632 A/G cg04362960 chr10:104952993 NT5C2 -0.54 -8.01 -0.4 1.97e-14 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs7953508 0.506 rs930316 chr12:93967035 A/G cg18151635 chr12:93972918 NA -0.8 -11.67 -0.54 1.42e-26 Pubertal anthropometrics; CRC cis rs1215050 0.765 rs1588018 chr4:98756324 G/C cg05340658 chr4:99064831 C4orf37 0.44 6.45 0.33 4.07e-10 Waist-to-hip ratio adjusted for body mass index; CRC cis rs7617480 0.617 rs7610519 chr3:48746427 C/G cg20833759 chr3:49053208 WDR6;DALRD3 0.58 9.0 0.44 1.87e-17 Subjective well-being (multi-trait analysis);Menarche (age at onset); CRC cis rs3087591 0.960 rs2018634 chr17:29560678 A/C cg24425628 chr17:29625626 OMG;NF1 -0.86 -16.57 -0.67 2.97e-45 Hip circumference; CRC cis rs6582630 0.599 rs12824838 chr12:38373584 G/T cg26384229 chr12:38710491 ALG10B -0.52 -7.62 -0.39 2.76e-13 Drug-induced liver injury (flucloxacillin); CRC cis rs9393692 0.905 rs7761298 chr6:26278436 C/T cg13736514 chr6:26305472 NA -0.61 -11.46 -0.53 8.56e-26 Educational attainment; CRC cis rs1348850 0.567 rs7605609 chr2:178534942 C/G cg22681709 chr2:178499509 PDE11A -0.45 -8.3 -0.42 2.8e-15 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC trans rs1814175 0.669 rs12364577 chr11:49707361 A/C cg15704280 chr7:45808275 SEPT13 -0.75 -12.19 -0.56 1.89e-28 Height; CRC cis rs853679 0.513 rs9468296 chr6:28113730 A/G cg21251018 chr6:28226885 NKAPL 0.48 6.17 0.32 2.02e-9 Depression; CRC cis rs6460942 0.591 rs62448729 chr7:12333720 G/C cg06484146 chr7:12443880 VWDE -0.64 -6.83 -0.35 4.2e-11 Coronary artery disease; CRC cis rs9928842 0.882 rs1107593 chr16:75261329 G/C cg09066997 chr16:75300724 BCAR1 0.68 6.36 0.33 6.83e-10 Alcoholic chronic pancreatitis; CRC cis rs9916302 0.904 rs801420 chr17:37466103 C/G cg03013999 chr17:37608204 MED1 -0.48 -7.51 -0.38 5.62e-13 Glomerular filtration rate (creatinine); CRC cis rs7119 0.717 rs62009070 chr15:77817884 G/C cg27398640 chr15:77910606 LINGO1 -0.43 -7.47 -0.38 7.13e-13 Type 2 diabetes; CRC cis rs10760158 0.832 rs10760172 chr9:124061902 C/T cg14417974 chr9:124058376 GSN -0.34 -5.73 -0.3 2.32e-8 Pulse pressure; CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg03533382 chr5:126853128 PRRC1 -0.57 -7.1 -0.36 7.69e-12 Diisocyanate-induced asthma; CRC cis rs7666738 0.830 rs7684646 chr4:99071062 C/T cg05340658 chr4:99064831 C4orf37 0.61 9.5 0.46 4.66e-19 Colonoscopy-negative controls vs population controls; CRC cis rs3741404 0.620 rs882147 chr11:63976689 T/A cg18225595 chr11:63971243 STIP1 0.53 8.55 0.43 4.69e-16 Platelet count; CRC cis rs2625529 0.652 rs2957750 chr15:72332258 C/T cg16672083 chr15:72433130 SENP8 0.43 6.37 0.33 6.37e-10 Red blood cell count; CRC cis rs3764400 0.517 rs7209042 chr17:46207792 G/C cg10706073 chr17:46328419 SKAP1 0.58 6.26 0.33 1.22e-9 Body mass index; CRC cis rs9783347 0.857 rs4150561 chr11:18354877 T/C cg15585147 chr11:18324498 HPS5 0.45 6.34 0.33 7.44e-10 Pancreatic cancer; CRC trans rs9914544 0.545 rs9912568 chr17:18792719 G/A cg21372672 chr17:16614065 CCDC144A -0.38 -6.1 -0.32 3e-9 Educational attainment (years of education); CRC cis rs6951245 0.748 rs79658522 chr7:1095877 A/G cg18402987 chr7:1209562 NA 0.67 7.15 0.37 5.54e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs10791323 0.569 rs5019134 chr11:133713082 G/C cg03690763 chr11:133734501 NA -0.34 -5.78 -0.3 1.71e-8 Childhood ear infection; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg05765466 chr1:45957060 TESK2 0.49 6.19 0.32 1.83e-9 Thyroid stimulating hormone; CRC cis rs7584330 0.518 rs74003109 chr2:238448150 C/T cg14458575 chr2:238380390 NA 0.65 8.02 0.4 1.82e-14 Prostate cancer; CRC cis rs17253792 0.822 rs17683656 chr14:56053361 C/T cg01858014 chr14:56050164 KTN1 0.84 7.17 0.37 4.9e-12 Putamen volume; CRC cis rs9291683 0.632 rs7679916 chr4:10042160 C/T cg00071950 chr4:10020882 SLC2A9 0.67 12.66 0.57 3.38e-30 Bone mineral density; CRC cis rs875971 1.000 rs7789768 chr7:65938980 A/C cg18912574 chr7:65842487 NCRNA00174 0.36 6.1 0.32 2.97e-9 Aortic root size; CRC trans rs8123881 0.733 rs7268466 chr20:15810676 C/T cg03632145 chr6:24403130 MRS2 0.56 6.06 0.32 3.74e-9 Body mass index; CRC cis rs172166 0.538 rs1150686 chr6:28161271 T/G cg21251018 chr6:28226885 NKAPL 0.59 10.3 0.49 9.21e-22 Cardiac Troponin-T levels; CRC cis rs3126085 0.825 rs868303 chr1:152178563 C/A cg09127314 chr1:152161683 NA 0.51 6.48 0.34 3.44e-10 Atopic dermatitis; CRC cis rs780096 0.565 rs11681351 chr2:27743423 G/A cg24768116 chr2:27665128 KRTCAP3 -0.33 -7.15 -0.37 5.67e-12 Total body bone mineral density; CRC cis rs501120 0.584 rs1746034 chr10:44714768 T/C cg09554077 chr10:44749378 NA 0.65 7.29 0.37 2.37e-12 Coronary artery disease;Coronary heart disease; CRC cis rs9612 1.000 rs28446957 chr19:44246600 T/A cg08581076 chr19:44259116 C19orf61 0.55 6.91 0.36 2.52e-11 Exhaled nitric oxide output; CRC cis rs10493773 0.775 rs2069208 chr1:86117583 T/C cg17807903 chr1:86174739 ZNHIT6 -0.51 -11.14 -0.52 1.1e-24 Urate levels in overweight individuals; CRC cis rs2197308 0.740 rs1842595 chr12:37906223 G/A cg13010199 chr12:38710504 ALG10B -0.47 -6.92 -0.36 2.32e-11 Morning vs. evening chronotype; CRC cis rs9527 0.590 rs12415388 chr10:104796345 T/C cg04362960 chr10:104952993 NT5C2 0.59 8.53 0.43 5.48e-16 Arsenic metabolism; CRC cis rs7020830 0.861 rs6476622 chr9:37308049 T/A cg14294708 chr9:37120828 ZCCHC7 1.17 26.86 0.83 6.04e-85 Schizophrenia; CRC cis rs736801 0.780 rs2188962 chr5:131770805 C/T cg12564285 chr5:131593104 PDLIM4 0.33 5.72 0.3 2.4e-8 Breast cancer;Mosquito bite size; CRC cis rs6041 0.822 rs1755685 chr13:113757192 A/C cg09069900 chr13:113776964 F10 0.43 7.04 0.36 1.14e-11 End-stage coagulation; CRC cis rs6809651 0.524 rs79262908 chr3:185803594 C/T cg00760338 chr3:185826511 ETV5 -0.74 -9.24 -0.45 3.04e-18 Body mass index in physically active individuals;Glomerular filtration rate (creatinine);Body mass index (joint analysis main effects and physical activity interaction);Body mass index;Body mass index in physically inactive individuals; CRC cis rs694739 0.628 rs538147 chr11:64129722 G/A cg23796481 chr11:64053134 BAD;GPR137 0.48 6.8 0.35 5.01e-11 Alopecia areata;Crohn's disease;Psoriasis vulgaris; CRC cis rs12474201 0.588 rs3768719 chr2:46987935 T/G cg06386533 chr2:46925753 SOCS5 0.58 8.86 0.44 5.05e-17 Height; CRC cis rs6952808 0.689 rs1107591 chr7:2041638 G/A cg00106254 chr7:1943704 MAD1L1 -0.54 -7.98 -0.4 2.47e-14 Bipolar disorder and schizophrenia; CRC cis rs7119 0.717 rs12904254 chr15:77802585 C/A cg27398640 chr15:77910606 LINGO1 -0.46 -7.77 -0.39 1.01e-13 Type 2 diabetes; CRC cis rs4713675 0.584 rs4711339 chr6:33667199 A/G cg14003231 chr6:33640908 ITPR3 0.49 8.01 0.4 1.94e-14 Plateletcrit; CRC cis rs79976124 0.837 rs12201218 chr6:66653619 C/T cg07460842 chr6:66804631 NA -0.75 -9.25 -0.45 2.94e-18 Type 2 diabetes; CRC cis rs7705042 0.865 rs249642 chr5:141524980 G/C cg08523384 chr5:141488047 NDFIP1 -0.32 -5.71 -0.3 2.5e-8 Asthma; CRC cis rs4689388 0.890 rs4688989 chr4:6290594 T/C cg00701064 chr4:6280414 WFS1 0.74 12.44 0.57 2.15e-29 Type 2 diabetes and other traits;Type 2 diabetes; CRC trans rs10504229 0.953 rs67677367 chr8:58175264 T/G cg04077850 chr5:125800366 GRAMD3 0.37 6.27 0.33 1.15e-9 Developmental language disorder (linguistic errors); CRC cis rs282587 0.569 rs428270 chr13:113411956 T/G cg04656015 chr13:113407548 ATP11A 0.64 8.28 0.42 3.04e-15 Glycated hemoglobin levels; CRC cis rs7615952 0.800 rs12489350 chr3:125644116 T/C cg05084668 chr3:125655381 ALG1L -0.59 -9.03 -0.45 1.5e-17 Blood pressure (smoking interaction); CRC cis rs7113874 0.513 rs2015629 chr11:8564426 A/T cg02811074 chr11:8615871 STK33 -0.37 -6.23 -0.33 1.39e-9 Body mass index in physically active individuals;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs6461049 0.734 rs1558465 chr7:2151398 G/C cg04267008 chr7:1944627 MAD1L1 -0.49 -6.88 -0.35 3.03e-11 Schizophrenia; CRC cis rs597539 0.652 rs514296 chr11:68654182 G/T cg21963583 chr11:68658836 MRPL21 0.62 11.53 0.54 4.68e-26 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs4930103 0.935 rs4930098 chr11:2020955 G/C cg23202291 chr11:1979235 NA 0.48 6.59 0.34 1.78e-10 DNA methylation (parent-of-origin);DNA methylation (variation); CRC cis rs10256972 0.577 rs2949179 chr7:1209885 C/G cg03923535 chr7:1197113 ZFAND2A 0.71 10.73 0.51 3.25e-23 Longevity;Endometriosis; CRC cis rs8141529 0.753 rs5752813 chr22:29226570 T/G cg15103426 chr22:29168792 CCDC117 0.56 8.08 0.41 1.28e-14 Lymphocyte counts; CRC cis rs4555082 0.915 rs2816632 chr14:105741355 C/T cg10792982 chr14:105748885 BRF1 -0.32 -5.85 -0.31 1.19e-8 Mean platelet volume;Platelet distribution width; CRC cis rs911555 0.755 rs8014800 chr14:103946302 T/C cg12935359 chr14:103987150 CKB 0.56 9.12 0.45 7.89e-18 Intelligence (multi-trait analysis); CRC cis rs597539 0.552 rs6591360 chr11:68718669 G/T cg21963583 chr11:68658836 MRPL21 0.53 9.34 0.46 1.52e-18 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs9517320 1.000 rs912337 chr13:99141272 A/G cg07423050 chr13:99094983 FARP1 -0.36 -5.83 -0.31 1.3e-8 Longevity; CRC cis rs12540874 0.698 rs3823674 chr7:50571996 C/T cg14593290 chr7:50529359 DDC -0.45 -6.33 -0.33 7.96e-10 Systemic sclerosis; CRC trans rs11885103 0.543 rs2685227 chr2:561099 T/C cg12228919 chr15:44955936 SPG11 -0.46 -6.87 -0.35 3.13e-11 Heschl's gyrus morphology; CRC cis rs4665809 0.590 rs62128457 chr2:26467347 C/A cg22920501 chr2:26401640 FAM59B 0.83 11.96 0.55 1.28e-27 Gut microbiome composition (summer); CRC cis rs6089584 0.927 rs3787427 chr20:60579789 T/C cg23262073 chr20:60523788 NA -0.41 -6.91 -0.36 2.47e-11 Body mass index; CRC cis rs9325144 0.647 rs12830095 chr12:38864199 C/T cg26384229 chr12:38710491 ALG10B -0.5 -7.22 -0.37 3.66e-12 Morning vs. evening chronotype; CRC cis rs490234 0.812 rs4329365 chr9:128445758 A/C cg14078157 chr9:128172775 NA -0.35 -5.74 -0.3 2.17e-8 Mean arterial pressure; CRC cis rs7618915 0.501 rs1468638 chr3:52748058 T/C cg18099408 chr3:52552593 STAB1 -0.46 -7.71 -0.39 1.48e-13 Bipolar disorder; CRC cis rs365302 1.000 rs542031 chr6:159651967 A/C cg14500486 chr6:159655392 FNDC1 0.44 6.82 0.35 4.31e-11 Coronary heart disease; CRC cis rs2227564 0.794 rs2688620 chr10:75684532 A/G cg00564723 chr10:75632066 CAMK2G -0.32 -7.12 -0.37 7e-12 Crohn's disease;Inflammatory bowel disease; CRC cis rs939574 1.000 rs1024131 chr2:220117458 G/A cg00496455 chr2:220118770 TUBA4A;TUBA4B 0.89 8.98 0.44 2.2e-17 Platelet distribution width; CRC trans rs7824557 0.564 rs13274106 chr8:11233958 A/G cg06636001 chr8:8085503 FLJ10661 -0.49 -7.4 -0.38 1.16e-12 Retinal vascular caliber; CRC cis rs1881797 1.000 rs67977965 chr1:247687835 G/A cg11166453 chr1:247681781 NA 0.42 6.95 0.36 1.93e-11 Acute lymphoblastic leukemia (childhood); CRC cis rs1707322 0.691 rs28495425 chr1:46187320 T/G cg06784218 chr1:46089804 CCDC17 0.66 12.27 0.56 9.04e-29 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs1218582 0.774 rs2335409 chr1:154916106 G/A cg24250549 chr1:154909240 PMVK 0.59 9.32 0.46 1.73e-18 Prostate cancer; CRC cis rs2625529 0.617 rs2128112 chr15:72186286 A/T cg16672083 chr15:72433130 SENP8 0.46 7.09 0.36 8.39e-12 Red blood cell count; CRC cis rs6952808 0.594 rs3778969 chr7:2139990 A/G cg22963979 chr7:1858916 MAD1L1 0.45 6.48 0.34 3.26e-10 Bipolar disorder and schizophrenia; CRC cis rs9902453 0.845 rs3102558 chr17:28023142 C/A cg26525008 chr17:28256777 EFCAB5;SSH2 0.6 8.98 0.44 2.17e-17 Coffee consumption (cups per day); CRC cis rs2836633 0.965 rs2836621 chr21:40054149 C/T cg12884169 chr21:40033163 ERG 0.36 7.89 0.4 4.64e-14 Coronary artery disease; CRC cis rs9733 0.596 rs11204704 chr1:150671630 T/C cg17724175 chr1:150552817 MCL1 0.6 9.61 0.47 1.89e-19 Tonsillectomy; CRC cis rs9311474 0.713 rs352166 chr3:52238677 C/T cg18099408 chr3:52552593 STAB1 -0.35 -5.7 -0.3 2.69e-8 Electroencephalogram traits; CRC cis rs7020830 0.931 rs7851239 chr9:37138672 A/G cg14294708 chr9:37120828 ZCCHC7 -1.08 -20.51 -0.75 8.6e-61 Schizophrenia; CRC cis rs875971 0.545 rs17138156 chr7:65714695 C/T cg11764359 chr7:65958608 NA 0.46 5.85 0.31 1.21e-8 Aortic root size; CRC cis rs11971779 0.584 rs7786469 chr7:139094621 G/A cg07862535 chr7:139043722 LUC7L2 0.57 7.35 0.38 1.61e-12 Diisocyanate-induced asthma; CRC cis rs514406 0.505 rs12726160 chr1:53175099 A/G cg27535305 chr1:53392650 SCP2 -0.31 -5.63 -0.3 3.85e-8 Monocyte count; CRC cis rs6570726 0.935 rs415590 chr6:145851244 T/C cg23711669 chr6:146136114 FBXO30 0.68 12.3 0.56 7.07e-29 Lobe attachment (rater-scored or self-reported); CRC cis rs644799 0.965 rs545342 chr11:95545369 T/C cg25478527 chr11:95522999 CEP57;FAM76B 0.51 7.69 0.39 1.68e-13 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs9467773 0.620 rs4368798 chr6:26593471 A/G cg09904177 chr6:26538194 HMGN4 0.73 11.54 0.54 4.38e-26 Intelligence (multi-trait analysis); CRC trans rs9291683 0.527 rs3822247 chr4:10094671 G/A cg26043149 chr18:55253948 FECH -0.53 -7.75 -0.39 1.13e-13 Bone mineral density; CRC cis rs9311676 0.632 rs57700771 chr3:58360327 G/A cg06643156 chr3:58380774 PXK 0.43 6.73 0.35 7.6e-11 Systemic lupus erythematosus; CRC cis rs7044106 0.762 rs1867254 chr9:123429078 C/T cg09586646 chr9:123605570 PSMD5;LOC253039 0.6 8.55 0.43 4.64e-16 Hip circumference adjusted for BMI; CRC cis rs6754311 0.731 rs892715 chr2:136576577 T/C cg25344623 chr2:136566232 LCT 0.32 5.81 0.31 1.47e-8 Mosquito bite size; CRC cis rs3857067 1.000 rs3857068 chr4:95026494 C/G cg11021082 chr4:95130006 SMARCAD1 0.4 6.04 0.32 4.11e-9 QT interval; CRC cis rs4853036 0.903 rs13021969 chr2:70117602 T/C cg02498382 chr2:70120550 SNRNP27 -0.44 -6.72 -0.35 8.12e-11 Colorectal or endometrial cancer; CRC cis rs7727544 0.735 rs272875 chr5:131674888 T/C cg12564285 chr5:131593104 PDLIM4 0.31 5.68 0.3 2.99e-8 Blood metabolite levels; CRC cis rs7517126 1.000 rs34833349 chr1:196870299 A/G cg13682187 chr1:196946512 CFHR5 -0.42 -6.09 -0.32 3.2e-9 Blood protein levels; CRC trans rs629535 0.821 rs680993 chr8:70050247 G/A cg21567404 chr3:27674614 NA 0.96 16.25 0.67 5.03e-44 Dupuytren's disease; CRC cis rs9814567 0.806 rs11927540 chr3:134319455 C/T cg06109529 chr3:134205091 CEP63;ANAPC13 -0.7 -10.55 -0.5 1.36e-22 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs477692 1.000 rs530466 chr10:131427717 A/G cg05714579 chr10:131428358 MGMT 0.57 8.48 0.42 7.72e-16 Response to temozolomide; CRC cis rs889312 0.500 rs1867731 chr5:56132115 C/G cg24531977 chr5:56204891 C5orf35 -0.45 -6.9 -0.36 2.64e-11 Breast cancer;Breast cancer (early onset); CRC cis rs1401999 1.000 rs4148571 chr3:183720576 A/C cg20387954 chr3:183756860 HTR3D 0.46 7.96 0.4 2.89e-14 Anterior chamber depth; CRC cis rs1552244 0.935 rs35586456 chr3:10116938 A/G cg02579736 chr3:10068473 FANCD2;CIDECP 0.97 13.13 0.59 6.13e-32 Alzheimer's disease; CRC trans rs4955793 0.537 rs9875529 chr3:178651680 A/T cg11644478 chr21:40555479 PSMG1 0.66 6.06 0.32 3.69e-9 Post-traumatic stress disorder (asjusted for relatedness); CRC cis rs1580019 0.885 rs4580942 chr7:32496435 A/G cg06627557 chr7:32535165 LSM5;AVL9 0.71 11.18 0.52 8.41e-25 Cognitive ability; CRC cis rs7224685 0.539 rs2054039 chr17:4014538 C/A cg09695851 chr17:3907499 NA 0.65 11.29 0.53 3.23e-25 Type 2 diabetes; CRC cis rs10504229 0.683 rs2318144 chr8:58114743 G/A cg22535103 chr8:58192502 C8orf71 -0.72 -8.21 -0.41 5.04e-15 Developmental language disorder (linguistic errors); CRC cis rs4594175 0.926 rs72688713 chr14:51598375 C/T cg23942311 chr14:51606299 NA 0.66 10.56 0.5 1.26e-22 Cancer; CRC cis rs1882538 0.503 rs1345938 chr7:133137867 C/T cg10665199 chr7:133106180 EXOC4 -0.65 -9.91 -0.48 1.97e-20 Intelligence (multi-trait analysis); CRC cis rs13118159 0.836 rs2293630 chr4:1342521 G/A cg20887711 chr4:1340912 KIAA1530 0.4 5.61 0.3 4.29e-8 Longevity; CRC cis rs13256369 1.000 rs10088439 chr8:8576699 T/G cg00074818 chr8:8560427 CLDN23 0.36 6.52 0.34 2.68e-10 Obesity-related traits; CRC cis rs501120 0.713 rs676966 chr10:44739594 A/G cg09554077 chr10:44749378 NA -0.73 -8.33 -0.42 2.26e-15 Coronary artery disease;Coronary heart disease; CRC cis rs9611565 0.921 rs5758297 chr22:41720697 A/G cg03806693 chr22:41940476 POLR3H -0.63 -8.86 -0.44 5.09e-17 Vitiligo; CRC cis rs9649213 0.593 rs6967576 chr7:98016373 A/G cg00277769 chr7:97922759 BAIAP2L1 0.54 9.07 0.45 1.1e-17 Prostate cancer (SNP x SNP interaction); CRC cis rs6665290 0.935 rs6704144 chr1:227201030 C/G cg10327440 chr1:227177885 CDC42BPA -0.99 -20.4 -0.75 2.34e-60 Myeloid white cell count; CRC cis rs2732480 0.577 rs2732486 chr12:48737834 G/A cg04545296 chr12:48745243 ZNF641 0.36 6.19 0.32 1.81e-9 Hemoglobin concentration;Red blood cell count;Hematocrit; CRC cis rs7849270 1.000 rs34055941 chr9:131895076 T/C cg13538475 chr9:131942899 NA -0.31 -6.1 -0.32 2.97e-9 Blood metabolite ratios; CRC cis rs7586879 0.575 rs6712981 chr2:25126230 A/G cg04586622 chr2:25135609 ADCY3 -0.54 -10.01 -0.48 9.31e-21 Body mass index; CRC cis rs9527 0.615 rs12248123 chr10:104735366 A/G cg04362960 chr10:104952993 NT5C2 0.6 8.53 0.43 5.49e-16 Arsenic metabolism; CRC cis rs2836974 0.568 rs452377 chr21:40537183 T/C cg17971929 chr21:40555470 PSMG1 0.74 11.81 0.55 4.55e-27 Cognitive function; CRC cis rs728616 0.867 rs2152548 chr10:81802667 G/A cg05935833 chr10:81318306 SFTPA2 -0.64 -7.35 -0.38 1.56e-12 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs17826219 0.706 rs8075357 chr17:29057197 A/C cg01831904 chr17:28903510 LRRC37B2 -0.62 -6.36 -0.33 6.9e-10 Body mass index; CRC cis rs778371 0.915 rs748002 chr2:233757679 G/A cg25237894 chr2:233734115 C2orf82 -0.41 -5.68 -0.3 2.98e-8 Schizophrenia; CRC cis rs9902453 0.904 rs7213076 chr17:28419428 G/A cg26525008 chr17:28256777 EFCAB5;SSH2 -0.72 -12.03 -0.55 6.96e-28 Coffee consumption (cups per day); CRC cis rs9611565 0.765 rs132921 chr22:41812044 G/A cg03806693 chr22:41940476 POLR3H 0.97 12.45 0.57 2.01e-29 Vitiligo; CRC cis rs1448094 0.967 rs2405789 chr12:86320466 C/T cg19622623 chr12:86230825 RASSF9 0.35 5.82 0.31 1.43e-8 Major depressive disorder; CRC cis rs72634258 0.945 rs7539255 chr1:8133352 T/C cg26816564 chr1:7831052 VAMP3 0.6 6.36 0.33 6.59e-10 Inflammatory bowel disease; CRC cis rs9649213 0.555 rs6968193 chr7:97915902 C/T cg00277769 chr7:97922759 BAIAP2L1 -0.61 -10.79 -0.51 1.87e-23 Prostate cancer (SNP x SNP interaction); CRC cis rs2075371 1.000 rs2598285 chr7:133971153 A/T cg11752832 chr7:134001865 SLC35B4 0.48 7.44 0.38 8.89e-13 Mean platelet volume; CRC cis rs372883 0.901 rs8133749 chr21:30615935 C/T cg24692254 chr21:30365293 RNF160 -0.37 -5.66 -0.3 3.3e-8 Pancreatic cancer; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg01300405 chr19:19626978 NDUFA13;TSSK6 0.37 6.02 0.31 4.53e-9 Liver disease severity in Alagille syndrome; CRC cis rs9611565 0.659 rs202653 chr22:41840158 C/T cg03806693 chr22:41940476 POLR3H 0.96 12.82 0.58 8.27e-31 Vitiligo; CRC cis rs7726839 0.540 rs72703079 chr5:595173 T/C cg14541582 chr5:601475 NA -0.35 -7.25 -0.37 3.02e-12 Obesity-related traits; CRC cis rs72634258 0.945 rs35675666 chr1:8021973 G/T cg00042356 chr1:8021962 PARK7 0.68 8.15 0.41 7.65e-15 Inflammatory bowel disease; CRC cis rs10504229 1.000 rs68076606 chr8:58191271 A/G cg02290350 chr8:58132656 NA -0.42 -5.96 -0.31 6.62e-9 Developmental language disorder (linguistic errors); CRC cis rs10208940 0.920 rs7423646 chr2:68758180 A/G cg12452813 chr2:68675892 NA 0.48 6.05 0.32 4.01e-9 Urate levels in lean individuals; CRC cis rs9322193 0.884 rs10872646 chr6:150067675 A/G cg00933542 chr6:150070202 PCMT1 0.33 6.97 0.36 1.73e-11 Lung cancer; CRC cis rs16975963 0.793 rs59616348 chr19:38447753 G/A cg15135657 chr19:38346511 NA -0.41 -5.62 -0.3 4.14e-8 Longevity; CRC trans rs2055729 0.634 rs6601390 chr8:9740657 A/G cg06636001 chr8:8085503 FLJ10661 0.54 6.91 0.36 2.49e-11 Multiple myeloma (hyperdiploidy); CRC cis rs9296095 0.948 rs75080135 chr6:33552707 A/C cg14003231 chr6:33640908 ITPR3 0.6 8.35 0.42 1.87e-15 Platelet count; CRC cis rs11583043 0.918 rs3850453 chr1:101408933 T/C cg16556008 chr1:101360663 SLC30A7;EXTL2 0.56 7.87 0.4 5.12e-14 Ulcerative colitis;Inflammatory bowel disease; CRC cis rs911119 0.913 rs3004145 chr20:23582876 C/G cg16589663 chr20:23618590 CST3 -0.53 -7.57 -0.38 3.88e-13 Chronic kidney disease; CRC cis rs3820068 0.705 rs4646075 chr1:15827461 T/C cg27534772 chr1:16042836 PLEKHM2 0.41 6.95 0.36 1.99e-11 Systolic blood pressure; CRC cis rs7666738 0.678 rs7670805 chr4:99008763 A/G cg17366294 chr4:99064904 C4orf37 0.43 7.27 0.37 2.64e-12 Colonoscopy-negative controls vs population controls; CRC cis rs1524976 0.738 rs62252647 chr3:65438217 C/T cg16238336 chr3:65465873 MAGI1 -0.48 -6.36 -0.33 6.58e-10 PR interval; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg12525736 chr1:228269915 ARF1 -0.4 -5.98 -0.31 5.93e-9 Myopia (pathological); CRC trans rs12200782 0.649 rs9467744 chr6:26386711 T/C cg25800765 chr12:85673347 ALX1 0.26 5.96 0.31 6.54e-9 Small cell lung carcinoma; CRC cis rs4728302 0.703 rs3823572 chr7:133680601 G/A cg10665199 chr7:133106180 EXOC4 0.4 6.25 0.33 1.27e-9 Intelligence;Intelligence (multi-trait analysis); CRC cis rs597539 0.652 rs514833 chr11:68657734 C/T cg06112835 chr11:68658793 MRPL21 0.47 7.57 0.38 3.88e-13 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs6570726 0.791 rs427128 chr6:145865917 T/C cg23711669 chr6:146136114 FBXO30 0.76 13.24 0.59 2.19e-32 Lobe attachment (rater-scored or self-reported); CRC trans rs2303319 0.504 rs62189046 chr2:162612371 C/G cg22677401 chr17:46026860 NA -0.67 -6.07 -0.32 3.57e-9 Cognitive function; CRC cis rs1003719 0.715 rs7277820 chr21:38580309 A/G cg10648535 chr21:38446584 PIGP;TTC3 -0.46 -6.48 -0.34 3.36e-10 Eye color traits; CRC cis rs13191362 0.872 rs56404230 chr6:163252863 C/T cg21926612 chr6:163149169 PACRG;PARK2 0.71 9.1 0.45 9.12e-18 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg11184682 chr3:50365769 TUSC2 0.47 6.66 0.34 1.16e-10 Response to antipsychotic treatment; CRC cis rs755249 0.567 rs3118014 chr1:39914090 G/A cg18385671 chr1:39797026 MACF1 -0.4 -5.7 -0.3 2.71e-8 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs9583531 0.843 rs7999702 chr13:111382264 A/C cg24331049 chr13:111365604 ING1 -0.51 -5.79 -0.3 1.6e-8 Coronary artery disease; CRC cis rs7586879 0.681 rs6545790 chr2:25109302 A/G cg22495460 chr2:25135724 ADCY3 -0.85 -16.47 -0.67 7.33e-45 Body mass index; CRC cis rs7727544 0.669 rs113823725 chr5:131563501 C/G cg18301423 chr5:131593218 PDLIM4 0.31 5.63 0.3 3.86e-8 Blood metabolite levels; CRC cis rs7412746 0.658 rs1546376 chr1:150937661 A/G cg18016565 chr1:150552671 MCL1 0.43 6.09 0.32 3.15e-9 Melanoma; CRC cis rs2120019 1.000 rs67544533 chr15:75361539 A/G cg09165964 chr15:75287851 SCAMP5 -0.82 -13.09 -0.59 8.02e-32 Blood trace element (Zn levels); CRC cis rs853679 0.550 rs1225599 chr6:28165190 C/T cg12172441 chr6:28176163 NA 0.69 9.19 0.45 4.69e-18 Depression; CRC cis rs7605827 0.893 rs4668929 chr2:15719044 C/A cg19274914 chr2:15703543 NA 0.38 5.84 0.31 1.23e-8 Educational attainment (years of education); CRC cis rs4903604 0.581 rs11159279 chr14:78036358 C/T cg18872420 chr14:78023429 SPTLC2 0.35 6.03 0.32 4.38e-9 Gut microbiome composition (winter); CRC cis rs78456975 1.000 rs28742145 chr2:1562671 T/C cg26248373 chr2:1572462 NA -0.66 -7.2 -0.37 4.09e-12 Placebo response in major depressive disorder (% change in symptom score); CRC cis rs79057730 0.599 rs4333501 chr7:803244 C/T cg05729249 chr7:766119 PRKAR1B;HEATR2 0.66 7.49 0.38 6.54e-13 Initial pursuit acceleration; CRC cis rs17767392 0.915 rs7147434 chr14:71811526 G/T cg13720639 chr14:72061746 SIPA1L1 -0.54 -6.68 -0.35 1.02e-10 Mitral valve prolapse; CRC cis rs6933660 0.720 rs6914656 chr6:151753421 C/G cg10883421 chr6:151773342 RMND1;C6orf211 0.76 13.33 0.59 1.07e-32 Menarche (age at onset); CRC trans rs13046373 0.905 rs4816372 chr21:32077414 A/T cg12575751 chr11:17297984 NUCB2 -0.41 -6.05 -0.32 4.04e-9 HDL cholesterol; CRC cis rs877282 0.947 rs7923867 chr10:768094 G/A cg06581033 chr10:766294 NA -0.52 -5.77 -0.3 1.84e-8 Uric acid levels; CRC cis rs1153858 1.000 rs72623915 chr15:45647433 C/T cg10760299 chr15:45669010 GATM 0.49 7.79 0.39 8.71e-14 Homoarginine levels; CRC cis rs2239547 0.522 rs2710345 chr3:52976075 T/C cg10802521 chr3:52805072 NEK4 0.45 6.2 0.32 1.7e-9 Schizophrenia; CRC cis rs3733585 0.699 rs6852441 chr4:9973744 C/T cg00071950 chr4:10020882 SLC2A9 -0.55 -9.81 -0.48 4.25e-20 Cleft plate (environmental tobacco smoke interaction); CRC cis rs5769765 0.862 rs9616392 chr22:50314705 G/A cg08270630 chr22:50330655 NA -0.4 -5.82 -0.31 1.39e-8 Schizophrenia; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg07839030 chr22:50946641 LMF2;NCAPH2 0.4 6.01 0.31 4.96e-9 Intelligence (multi-trait analysis); CRC cis rs13191362 1.000 rs34228197 chr6:163008232 A/G cg06582575 chr6:163149167 PACRG;PARK2 0.71 10.22 0.49 1.72e-21 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC trans rs7647973 0.593 rs9870755 chr3:49809841 A/G cg21665057 chr3:196295764 WDR53;FBXO45 -0.62 -6.88 -0.35 3.11e-11 Menarche (age at onset); CRC cis rs12476592 0.602 rs7571325 chr2:63785914 G/A cg10828910 chr2:63850056 LOC388955 0.49 6.11 0.32 2.79e-9 Childhood ear infection; CRC cis rs644799 0.544 rs499637 chr11:95569183 G/A cg03916912 chr11:95522834 CEP57;FAM76B 0.7 11.6 0.54 2.63e-26 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs4889855 0.530 rs7220588 chr17:78598231 G/A cg16591659 chr17:78472290 NA -0.43 -6.23 -0.32 1.42e-9 Fractional excretion of uric acid; CRC cis rs5753037 0.585 rs5752962 chr22:30188245 A/C cg01021169 chr22:30184971 ASCC2 -0.43 -6.9 -0.36 2.62e-11 Type 1 diabetes; CRC trans rs4072705 0.646 rs915034 chr9:127244955 G/A cg15061682 chr13:102850387 FGF14 -0.31 -6.04 -0.32 4.21e-9 Menarche (age at onset); CRC cis rs875971 0.825 rs66981195 chr7:66079035 C/A cg18876405 chr7:65276391 NA -0.54 -8.65 -0.43 2.29e-16 Aortic root size; CRC cis rs4700695 0.668 rs20768 chr5:65484805 C/T cg21114390 chr5:65439923 SFRS12 -0.59 -7.99 -0.4 2.25e-14 Facial morphology (factor 19); CRC cis rs2204008 0.805 rs4589389 chr12:37946120 C/A cg13010199 chr12:38710504 ALG10B -0.47 -6.85 -0.35 3.59e-11 Bladder cancer; CRC cis rs9326248 0.520 rs236919 chr11:117095361 A/G cg11861562 chr11:117069780 TAGLN 0.33 7.31 0.37 2.06e-12 Blood protein levels; CRC cis rs11123170 0.543 rs2166421 chr2:113990242 T/C cg21550016 chr2:113992930 PAX8;LOC440839;LOC654433 0.52 5.88 0.31 1.02e-8 Renal function-related traits (BUN); CRC cis rs4728302 0.838 rs6954700 chr7:133588739 G/A cg10665199 chr7:133106180 EXOC4 0.38 5.8 0.3 1.54e-8 Intelligence;Intelligence (multi-trait analysis); CRC cis rs11098499 0.564 rs11098507 chr4:120288286 G/A cg09307838 chr4:120376055 NA 0.68 10.53 0.5 1.51e-22 Corneal astigmatism; CRC cis rs9527 0.590 rs10786744 chr10:104945028 A/C cg04362960 chr10:104952993 NT5C2 -0.63 -8.86 -0.44 5.16e-17 Arsenic metabolism; CRC cis rs6748734 0.625 rs7598309 chr2:241824876 A/T cg16358738 chr2:241808595 AGXT -0.4 -6.99 -0.36 1.52e-11 Urinary metabolites; CRC cis rs2635047 1.000 rs2635043 chr18:44679769 A/G cg19077165 chr18:44547161 KATNAL2 -0.45 -7.48 -0.38 7.03e-13 Educational attainment; CRC cis rs28386778 0.734 rs7210724 chr17:61799198 T/C cg06873352 chr17:61820015 STRADA 0.79 14.79 0.63 2.66e-38 Prudent dietary pattern; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg16608617 chr2:202898681 FZD7 0.44 6.87 0.35 3.18e-11 Liver disease severity in Alagille syndrome; CRC cis rs11608355 0.810 rs2217971 chr12:109857666 G/C cg19025524 chr12:109796872 NA -0.45 -6.05 -0.32 3.98e-9 Neuroticism; CRC cis rs4237845 0.837 rs7971877 chr12:58287630 T/G cg02175503 chr12:58329896 NA 0.59 8.38 0.42 1.56e-15 Intelligence (multi-trait analysis); CRC cis rs2976388 0.647 rs2164307 chr8:143788831 A/T cg05569086 chr8:143859399 LYNX1 0.38 6.74 0.35 7.09e-11 Urinary tract infection frequency; CRC cis rs2859741 1.000 rs2859741 chr1:37509352 C/T cg09363841 chr1:37513479 NA -0.63 -11.56 -0.54 3.75e-26 Forced expiratory volume in 1 second (environmental tobacco smoke interaction); CRC cis rs9463078 0.617 rs9381365 chr6:45077975 G/A cg25276700 chr6:44698697 NA -0.24 -5.76 -0.3 1.97e-8 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; CRC cis rs7914558 0.966 rs11191471 chr10:104702050 T/A cg15744005 chr10:104629667 AS3MT -0.35 -7.55 -0.38 4.22e-13 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs9287719 0.686 rs10174605 chr2:10725232 G/A cg00105475 chr2:10696890 NA 0.44 7.0 0.36 1.43e-11 Prostate cancer; CRC cis rs35306767 0.951 rs61833265 chr10:990143 C/T cg20503657 chr10:835505 NA 1.0 12.2 0.56 1.68e-28 Eosinophil percentage of granulocytes; CRC trans rs7267979 0.966 rs2257461 chr20:25265554 A/G cg17903999 chr18:56338584 MALT1 -0.41 -6.88 -0.35 3.08e-11 Liver enzyme levels (alkaline phosphatase); CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg17832277 chr13:103249000 TPP2 -0.5 -5.96 -0.31 6.51e-9 Diisocyanate-induced asthma; CRC cis rs6840360 1.000 rs7669977 chr4:152677527 T/C cg09659197 chr4:152720779 NA 0.52 11.39 0.53 1.43e-25 Intelligence (multi-trait analysis); CRC cis rs34172651 0.583 rs4787649 chr16:24700215 C/T cg02428538 chr16:24856791 SLC5A11 0.58 7.02 0.36 1.25e-11 Intelligence (multi-trait analysis); CRC cis rs77861329 1.000 rs13319566 chr3:52095555 C/G cg08692210 chr3:52188851 WDR51A 0.88 8.43 0.42 1.1e-15 Macrophage inflammatory protein 1b levels; CRC cis rs863345 0.604 rs1157525 chr1:158457253 T/C cg12129480 chr1:158549410 OR10X1 -0.29 -6.07 -0.32 3.49e-9 Pneumococcal bacteremia; CRC cis rs17767392 0.958 rs3784066 chr14:72007454 A/T cg13720639 chr14:72061746 SIPA1L1 -0.57 -7.2 -0.37 4e-12 Mitral valve prolapse; CRC cis rs7618915 0.533 rs35107891 chr3:52613656 G/C cg07507251 chr3:52567010 NT5DC2 0.46 6.73 0.35 7.48e-11 Bipolar disorder; CRC cis rs853679 0.598 rs9380054 chr6:28067537 G/A cg23161317 chr6:28129485 ZNF389 0.52 6.38 0.33 6.1e-10 Depression; CRC cis rs9368481 0.546 rs12664610 chr6:26885031 G/A cg18278486 chr6:26987575 LOC100270746;C6orf41 0.39 6.05 0.32 3.89e-9 Autism spectrum disorder or schizophrenia; CRC cis rs59918340 0.764 rs3824234 chr8:142229370 T/C cg17298326 chr8:142245477 NA -0.37 -5.65 -0.3 3.55e-8 Immature fraction of reticulocytes; CRC cis rs2976388 0.590 rs10110970 chr8:143820410 G/C cg12516270 chr8:143859308 LYNX1 -0.39 -6.44 -0.33 4.18e-10 Urinary tract infection frequency; CRC cis rs4862750 0.758 rs2375915 chr4:187896255 A/C cg03647317 chr4:187891568 NA -0.55 -10.46 -0.5 2.72e-22 Lobe attachment (rater-scored or self-reported); CRC cis rs12540874 0.698 rs12718574 chr7:50573848 G/C cg18232548 chr7:50535776 DDC -0.53 -7.93 -0.4 3.45e-14 Systemic sclerosis; CRC cis rs9549367 0.789 rs71446679 chr13:113894821 C/T cg18105134 chr13:113819100 PROZ -0.71 -10.34 -0.5 7.19e-22 Platelet distribution width; CRC cis rs10986311 0.802 rs6478659 chr9:127128274 A/G cg14243010 chr9:127117328 LOC100129034;PSMB7 -0.37 -5.64 -0.3 3.75e-8 Vitiligo; CRC cis rs9486719 1.000 rs11153064 chr6:97021959 A/G cg18709589 chr6:96969512 KIAA0776 -0.52 -5.85 -0.31 1.21e-8 Migraine;Coronary artery disease; CRC cis rs1218582 0.774 rs1007170 chr1:154881461 G/A cg06221963 chr1:154839813 KCNN3 -0.8 -16.05 -0.66 3.11e-43 Prostate cancer; CRC cis rs11098499 0.863 rs1480940 chr4:120457682 T/C cg09307838 chr4:120376055 NA 0.69 10.41 0.5 3.93e-22 Corneal astigmatism; CRC cis rs12291225 0.585 rs10832242 chr11:14340504 C/T cg19336497 chr11:14380999 RRAS2 0.51 9.11 0.45 8.09e-18 Sense of smell; CRC cis rs780094 0.564 rs4665978 chr2:27648726 T/C cg12648201 chr2:27665141 KRTCAP3 -0.29 -5.77 -0.3 1.78e-8 Calcium levels;Fasting blood insulin;Metabolic traits;Triglyceride levels;Fasting plasma glucose;Urate levels in overweight individuals;Urate levels in obese individuals;Uric acid levels;Height;Age-related diseases, mortality and associated endophenotypes;Renal underexcretion gout;Fasting blood glucose (BMI interaction);Urate levels;Gondoic acid (20:1n-9) levels;Fasting blood insulin (BMI interaction);Triglycerides;Plasma omega-3 polyunsaturated fatty acid levels (docosapentaenoic acid);Type 2 diabetes;Nonalcoholic fatty liver disease;Hypertriglyceridemia;C-reactive protein;Age-related disease endophenotypes;LDL cholesterol;Metabolic syndrome;Crohn's disease;Alcohol consumption (drinks per week);Homeostasis model assessment of insulin resistance;Alcohol consumption;Red blood cell count;Fasting blood glucose; CRC cis rs6500602 0.627 rs841231 chr16:4583147 C/T cg14951292 chr16:4525986 HMOX2;NMRAL1 -0.63 -9.05 -0.45 1.24e-17 Schizophrenia; CRC cis rs3015497 0.646 rs2934698 chr14:51137883 G/C cg26011998 chr14:51135199 SAV1 -0.46 -5.72 -0.3 2.39e-8 Mean platelet volume; CRC cis rs13031619 0.660 rs34855424 chr2:3702780 C/A cg25251562 chr2:3704773 ALLC -0.78 -9.7 -0.47 9.76e-20 Response to inhaled corticosteroid treatment in asthma (change in FEV1); CRC cis rs1881492 0.554 rs868746 chr2:233457831 A/G cg03852847 chr2:233439513 NA -0.42 -6.77 -0.35 5.92e-11 Refractive error; CRC cis rs9393692 1.000 rs9393692 chr6:26276650 A/G cg13736514 chr6:26305472 NA -0.64 -11.6 -0.54 2.63e-26 Educational attainment; CRC cis rs897984 0.542 rs4468641 chr16:31096876 A/C cg02466173 chr16:30829666 NA -0.59 -8.87 -0.44 4.73e-17 Dementia with Lewy bodies; CRC cis rs6951245 0.706 rs28522260 chr7:1183964 C/A cg03188948 chr7:1209495 NA 0.69 7.68 0.39 1.78e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs950027 0.595 rs2486288 chr15:45712339 T/C cg21132104 chr15:45694354 SPATA5L1 0.4 5.66 0.3 3.33e-8 Response to fenofibrate (adiponectin levels); CRC cis rs514406 0.861 rs11206026 chr1:53281708 G/A cg08859206 chr1:53392774 SCP2 -0.44 -6.71 -0.35 8.31e-11 Monocyte count; CRC cis rs1552244 1.000 rs9834980 chr3:10065528 G/A cg00166722 chr3:10149974 C3orf24 0.65 8.86 0.44 5.13e-17 Alzheimer's disease; CRC cis rs28386778 0.829 rs1877317 chr17:61776479 T/C cg23090583 chr17:61904693 PSMC5;FTSJ3 1.05 19.33 0.73 3.76e-56 Prudent dietary pattern; CRC cis rs4700695 0.841 rs957526 chr5:65345830 A/G cg21114390 chr5:65439923 SFRS12 0.51 6.37 0.33 6.27e-10 Facial morphology (factor 19); CRC cis rs9322193 0.923 rs4869750 chr6:150177132 C/T cg00933542 chr6:150070202 PCMT1 0.29 5.87 0.31 1.07e-8 Lung cancer; CRC cis rs6424115 0.830 rs2502995 chr1:24199290 T/C cg15997130 chr1:24165203 NA 0.72 10.57 0.5 1.16e-22 Immature fraction of reticulocytes; CRC cis rs7932354 0.583 rs10769211 chr11:46872873 G/A cg19486271 chr11:47235900 DDB2 -0.42 -6.34 -0.33 7.49e-10 Bone mineral density (hip);Bone mineral density; CRC cis rs1348850 0.526 rs7582179 chr2:178370631 A/G cg27490568 chr2:178487706 NA 0.57 7.07 0.36 9.44e-12 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs4400599 0.600 rs12095767 chr1:154188028 T/C cg26808167 chr1:154192205 UBAP2L;C1orf43 -0.37 -5.65 -0.3 3.39e-8 Platelet distribution width; CRC trans rs2243480 1.000 rs462853 chr7:65558167 G/C cg10756647 chr7:56101905 PSPH 0.69 7.49 0.38 6.21e-13 Diabetic kidney disease; CRC cis rs554111 1.000 rs554111 chr1:21042300 C/G cg00373020 chr1:21041521 KIF17 0.4 6.18 0.32 1.87e-9 Facial morphology (factor 17, height of vermillion upper lip); CRC cis rs7772486 0.875 rs2814872 chr6:146310234 T/C cg23711669 chr6:146136114 FBXO30 0.69 11.68 0.54 1.28e-26 Lobe attachment (rater-scored or self-reported); CRC cis rs7020830 0.858 rs67036212 chr9:37133538 A/G cg14294708 chr9:37120828 ZCCHC7 1.18 24.41 0.8 7.86e-76 Schizophrenia; CRC cis rs4363385 0.720 rs1611764 chr1:152957887 G/A cg25856811 chr1:152973957 SPRR3 -0.26 -7.25 -0.37 3.01e-12 Inflammatory skin disease; CRC cis rs7927592 0.956 rs10896348 chr11:68357368 T/C cg16797656 chr11:68205561 LRP5 0.39 6.7 0.35 9.05e-11 Total body bone mineral density; CRC cis rs9517320 0.534 rs9556962 chr13:99156648 C/T cg07423050 chr13:99094983 FARP1 -0.58 -8.09 -0.41 1.2e-14 Longevity; CRC cis rs10504229 0.683 rs2291765 chr8:58142874 C/T cg02725872 chr8:58115012 NA -0.56 -10.27 -0.49 1.21e-21 Developmental language disorder (linguistic errors); CRC cis rs796364 0.806 rs76112266 chr2:201087157 C/G cg25936922 chr2:200820526 C2orf60;C2orf47 -0.61 -5.67 -0.3 3.15e-8 Schizophrenia; CRC cis rs929354 0.707 rs1182445 chr7:157024428 C/G cg17757837 chr7:157058334 UBE3C -0.75 -12.98 -0.58 2.18e-31 Body mass index; CRC cis rs10752881 0.935 rs10911197 chr1:182995399 T/C ch.1.3577855R chr1:183094577 LAMC1 0.87 15.17 0.64 8.94e-40 Colorectal cancer; CRC cis rs6460942 0.730 rs73053536 chr7:12323131 C/G cg20607287 chr7:12443886 VWDE -0.66 -5.81 -0.3 1.51e-8 Coronary artery disease; CRC cis rs950169 1.000 rs11638297 chr15:84782417 A/C cg11189052 chr15:85197271 WDR73 0.59 8.57 0.43 4.2e-16 Schizophrenia; CRC cis rs9649213 0.593 rs6947208 chr7:97912204 C/T cg00277769 chr7:97922759 BAIAP2L1 -0.6 -10.56 -0.5 1.21e-22 Prostate cancer (SNP x SNP interaction); CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg27141267 chr11:66175971 NA 0.48 6.22 0.32 1.53e-9 Thyroid stimulating hormone; CRC cis rs10197940 0.662 rs10173699 chr2:152281561 C/G cg06191203 chr2:152266755 RIF1 0.67 9.54 0.47 3.43e-19 Lung cancer; CRC cis rs6951245 1.000 rs118059236 chr7:1073202 A/C cg21664854 chr7:1097933 C7orf50;GPR146 0.79 8.92 0.44 3.39e-17 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs10883723 0.810 rs3740406 chr10:104272789 C/T cg11453585 chr10:104263688 ACTR1A;SUFU 0.91 17.32 0.69 3.11e-48 Allergic disease (asthma, hay fever or eczema); CRC cis rs611744 0.647 rs9969614 chr8:109260581 A/G cg21045802 chr8:109455806 TTC35 0.43 6.97 0.36 1.75e-11 Dupuytren's disease; CRC cis rs1552244 0.816 rs13076197 chr3:10019773 T/C cg18598329 chr3:10140678 FANCD2;C3orf24 -0.81 -10.69 -0.51 4.18e-23 Alzheimer's disease; CRC trans rs10983614 1.000 rs7867776 chr9:120072627 A/G cg10766172 chr7:27498479 NA 0.48 6.74 0.35 7.2e-11 Survival in pancreatic cancer; CRC cis rs9478217 1 rs9478217 chr6:151874122 A/G cg10883421 chr6:151773342 RMND1;C6orf211 -0.38 -5.9 -0.31 9.14e-9 Total body bone mineral density (age 30-45); CRC cis rs7786808 0.608 rs9692003 chr7:158204696 G/A cg17401720 chr7:158221031 PTPRN2 -0.44 -7.38 -0.38 1.28e-12 Obesity-related traits; CRC cis rs9814567 1.000 rs9871305 chr3:134213538 C/T cg06541857 chr3:134203789 ANAPC13;CEP63 -0.39 -5.86 -0.31 1.15e-8 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs780096 0.546 rs2911712 chr2:27626945 A/T cg24768116 chr2:27665128 KRTCAP3 -0.36 -8.07 -0.41 1.38e-14 Total body bone mineral density; CRC cis rs4862750 0.832 rs10007858 chr4:187877492 A/G cg11301795 chr4:187892539 NA -0.86 -19.42 -0.73 1.58e-56 Lobe attachment (rater-scored or self-reported); CRC cis rs13191362 0.688 rs73035006 chr6:162997083 G/T cg23758597 chr6:163146217 PARK2 -0.55 -6.12 -0.32 2.61e-9 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs6738485 0.552 rs62146770 chr2:106854277 C/T cg16099169 chr2:106886729 NA -0.39 -6.65 -0.34 1.26e-10 Pursuit maintenance gain;Pursuit maintenance gain in psychotic disorders; CRC cis rs7618915 0.501 rs13085775 chr3:52678370 C/T cg18404041 chr3:52824283 ITIH1 -0.41 -8.63 -0.43 2.69e-16 Bipolar disorder; CRC cis rs4689388 0.890 rs6838400 chr4:6295427 C/G cg14416269 chr4:6271139 WFS1 0.4 6.59 0.34 1.72e-10 Type 2 diabetes and other traits;Type 2 diabetes; CRC cis rs10504229 0.679 rs11781858 chr8:58038406 C/T cg02290350 chr8:58132656 NA -0.56 -6.4 -0.33 5.27e-10 Developmental language disorder (linguistic errors); CRC cis rs1707322 0.752 rs61784793 chr1:46149285 G/A cg03146154 chr1:46216737 IPP 0.67 9.71 0.47 8.93e-20 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs11098499 0.779 rs72918579 chr4:120333222 G/C cg24375607 chr4:120327624 NA 0.51 7.66 0.39 2.14e-13 Corneal astigmatism; CRC cis rs6701037 0.625 rs67332874 chr1:175128537 G/A cg17845761 chr1:175162550 KIAA0040 -0.27 -5.61 -0.3 4.39e-8 Alcohol dependence; CRC cis rs9733 0.596 rs6678013 chr1:150623285 T/G cg15448220 chr1:150897856 SETDB1 0.45 6.43 0.33 4.42e-10 Tonsillectomy; CRC cis rs2243480 1.000 rs1267820 chr7:66050295 C/G cg12463550 chr7:65579703 CRCP 0.69 6.23 0.32 1.4e-9 Diabetic kidney disease; CRC cis rs7587476 0.689 rs78989396 chr2:215714816 C/T cg04004882 chr2:215674386 BARD1 0.65 9.04 0.45 1.38e-17 Neuroblastoma; CRC trans rs11098499 1.000 rs12506395 chr4:120185094 C/T cg25214090 chr10:38739885 LOC399744 0.51 7.83 0.4 6.77e-14 Corneal astigmatism; CRC cis rs9611565 0.659 rs4822037 chr22:41945113 G/T cg06481639 chr22:41940642 POLR3H -0.54 -6.14 -0.32 2.32e-9 Vitiligo; CRC cis rs704795 0.775 rs4665975 chr2:27626017 A/T cg02592271 chr2:27665507 KRTCAP3 -0.28 -5.93 -0.31 7.53e-9 Menopause (age at onset); CRC cis rs9303280 0.901 rs2313430 chr17:37929816 T/C cg20243544 chr17:37824526 PNMT -0.41 -6.5 -0.34 2.96e-10 Self-reported allergy; CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg07936430 chr16:30538244 ZNF768 0.39 6.06 0.32 3.62e-9 Obesity-related traits; CRC cis rs514406 0.893 rs2897561 chr1:53388747 C/A cg27535305 chr1:53392650 SCP2 -0.4 -7.17 -0.37 4.94e-12 Monocyte count; CRC cis rs9517320 0.515 rs72646416 chr13:99232916 C/G cg07423050 chr13:99094983 FARP1 -0.53 -7.44 -0.38 8.9e-13 Longevity; CRC cis rs9560113 0.960 rs9560101 chr13:112173798 G/A cg14154082 chr13:112174009 NA 0.35 5.71 0.3 2.59e-8 Menarche (age at onset); CRC trans rs747782 0.527 rs12289516 chr11:48234680 G/A cg03929089 chr4:120376271 NA 0.7 6.87 0.35 3.18e-11 Intraocular pressure; CRC cis rs9868809 0.505 rs11706203 chr3:48746239 T/A cg07636037 chr3:49044803 WDR6 -0.68 -6.55 -0.34 2.25e-10 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; CRC cis rs12048904 0.964 rs17123467 chr1:101331760 G/A cg00063077 chr1:101360652 SLC30A7;EXTL2 0.52 7.6 0.39 3.19e-13 Multiple sclerosis; CRC cis rs9487051 0.604 rs9320282 chr6:109619377 A/G cg12927641 chr6:109611667 NA -0.36 -6.34 -0.33 7.51e-10 Reticulocyte fraction of red cells; CRC cis rs13108904 0.539 rs13145722 chr4:1338422 T/A cg23123621 chr4:1343375 KIAA1530 0.36 5.68 0.3 3e-8 Obesity-related traits; CRC cis rs6831352 0.734 rs2602857 chr4:100030318 G/A cg13256891 chr4:100009986 ADH5 0.57 7.9 0.4 4.36e-14 Alcohol dependence; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg11861730 chr11:128392683 ETS1 0.41 6.04 0.32 4.08e-9 Response to antipsychotic treatment; CRC cis rs1562242 0.653 rs2441112 chr5:57601615 T/C cg09002358 chr5:57541568 NA 0.84 7.78 0.39 9.62e-14 Educational attainment (years of education); CRC cis rs1355223 1.000 rs11602909 chr11:34768003 T/C cg11058730 chr11:34937778 PDHX;APIP -0.45 -6.31 -0.33 9.11e-10 Systemic lupus erythematosus and Systemic sclerosis; CRC cis rs9487051 0.768 rs442405 chr6:109526980 T/G cg21918786 chr6:109611834 NA -0.35 -5.92 -0.31 8.13e-9 Reticulocyte fraction of red cells; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg14791747 chr16:20752902 THUMPD1 0.41 6.33 0.33 8.01e-10 Liver disease severity in Alagille syndrome; CRC cis rs2180341 0.960 rs7751865 chr6:127683040 G/A cg27446573 chr6:127587934 RNF146 0.92 13.23 0.59 2.47e-32 Breast cancer; CRC cis rs6740322 0.748 rs6732337 chr2:43462822 C/T cg06169590 chr2:43455088 ZFP36L2;LOC100129726 0.73 9.38 0.46 1.11e-18 Coronary artery disease; CRC cis rs9611565 0.546 rs2092274 chr22:42123737 A/G cg03806693 chr22:41940476 POLR3H 1.0 12.85 0.58 6.4e-31 Vitiligo; CRC cis rs950169 0.959 rs12902070 chr15:84793558 T/C cg17507749 chr15:85114479 UBE2QP1 0.76 11.84 0.55 3.48e-27 Schizophrenia; CRC trans rs1455244 0.700 rs7229302 chr18:11508904 G/T cg26599104 chr19:40932063 SERTAD1 0.39 5.99 0.31 5.46e-9 Schizophrenia; CRC cis rs6502050 0.799 rs6502088 chr17:80169484 C/T cg02741985 chr17:80059408 CCDC57 0.43 7.14 0.37 5.91e-12 Life satisfaction; CRC cis rs919433 0.680 rs788017 chr2:198265173 T/A cg10820045 chr2:198174542 NA 0.37 6.18 0.32 1.87e-9 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC cis rs3096299 0.967 rs7205785 chr16:89458984 A/G cg01788221 chr16:89496183 ANKRD11 -0.42 -6.22 -0.32 1.54e-9 Multiple myeloma (IgH translocation); CRC cis rs875971 0.929 rs6970860 chr7:65976634 A/G cg18912574 chr7:65842487 NCRNA00174 0.35 6.09 0.32 3.11e-9 Aortic root size; CRC cis rs10927875 0.691 rs1048261 chr1:16340951 A/T cg22431228 chr1:16359049 CLCNKA -0.42 -7.42 -0.38 1.04e-12 Dilated cardiomyopathy; CRC cis rs28386778 0.830 rs2597637 chr17:61875066 T/G cg11494091 chr17:61959527 GH2 0.62 10.57 0.5 1.13e-22 Prudent dietary pattern; CRC cis rs66569888 0.633 rs11680226 chr2:106745044 A/G cg16099169 chr2:106886729 NA 0.4 5.89 0.31 9.49e-9 Facial morphology (factor 23); CRC cis rs561341 1.000 rs72823785 chr17:30273784 C/T cg12193833 chr17:30244370 NA -0.74 -8.72 -0.43 1.45e-16 Hip circumference adjusted for BMI; CRC cis rs561341 0.882 rs563539 chr17:30307958 A/G cg23018236 chr17:30244563 NA -0.6 -8.06 -0.41 1.38e-14 Hip circumference adjusted for BMI; CRC cis rs2645694 0.626 rs2703136 chr4:77828957 T/A cg03477792 chr4:77819574 ANKRD56 0.46 6.62 0.34 1.49e-10 Emphysema distribution in smoking; CRC cis rs6973256 0.901 rs2991231 chr7:133321915 T/C cg10665199 chr7:133106180 EXOC4 -0.38 -5.97 -0.31 5.99e-9 Intelligence (multi-trait analysis); CRC cis rs6429082 0.509 rs2803846 chr1:235521054 C/G cg26050004 chr1:235667680 B3GALNT2 0.44 6.35 0.33 7.06e-10 Adiposity; CRC cis rs9640161 0.742 rs2108854 chr7:150017408 C/T cg12556325 chr7:150026731 C7orf29;LRRC61 0.44 6.49 0.34 3.17e-10 Blood protein levels;Circulating chemerin levels; CRC cis rs2885056 0.783 rs12459941 chr19:10666112 A/G cg06392426 chr19:10676186 KRI1 -0.56 -6.81 -0.35 4.75e-11 Red cell distribution width; CRC trans rs2303319 0.504 rs55840249 chr2:162426849 C/A cg09481857 chr22:21368659 P2RX6;MGC16703 -0.65 -6.12 -0.32 2.63e-9 Cognitive function; CRC cis rs763121 0.853 rs5757204 chr22:39046700 A/C cg06544989 chr22:39130855 UNC84B 0.44 6.85 0.35 3.71e-11 Menopause (age at onset); CRC cis rs4819052 0.765 rs2838868 chr21:46714641 A/G cg19498844 chr21:46707878 POFUT2;LOC642852 -0.77 -9.77 -0.47 5.98e-20 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs11098499 0.863 rs13140409 chr4:120503460 A/G cg09307838 chr4:120376055 NA 0.69 10.17 0.49 2.66e-21 Corneal astigmatism; CRC cis rs10751667 0.643 rs10751669 chr11:942344 C/G ch.11.42038R chr11:967971 AP2A2 -0.6 -10.2 -0.49 2.03e-21 Alzheimer's disease (late onset); CRC cis rs4919694 1.000 rs77505796 chr10:104647774 A/T cg04362960 chr10:104952993 NT5C2 1.23 10.39 0.5 4.73e-22 Arsenic metabolism; CRC cis rs807029 0.577 rs11190786 chr10:102757442 A/G cg04662943 chr10:102668895 NA 0.61 7.13 0.37 6.44e-12 Ejection fraction in Tripanosoma cruzi seropositivity; CRC cis rs780096 0.526 rs2010087 chr2:27637235 C/T cg21248554 chr2:27665150 KRTCAP3 -0.32 -7.38 -0.38 1.34e-12 Total body bone mineral density; CRC trans rs800082 0.539 rs1178897 chr3:144241161 A/C cg24215973 chr2:240111563 HDAC4 -0.43 -6.02 -0.31 4.79e-9 Smoking behavior; CRC trans rs45509595 0.749 rs401763 chr6:27782528 T/C cg06606381 chr12:133084897 FBRSL1 -0.78 -6.64 -0.34 1.26e-10 Breast cancer; CRC cis rs1448094 0.836 rs6539935 chr12:86376809 T/C cg02569458 chr12:86230093 RASSF9 0.4 6.8 0.35 4.93e-11 Major depressive disorder; CRC cis rs2274273 0.624 rs67412516 chr14:55853237 A/T cg10130446 chr14:55658398 DLGAP5 -0.42 -5.78 -0.3 1.71e-8 Protein biomarker; CRC cis rs4713118 0.513 rs1225591 chr6:28148752 G/A cg02683197 chr6:28174875 NA 0.7 9.78 0.47 5.24e-20 Parkinson's disease; CRC cis rs896854 0.625 rs7823886 chr8:95986459 A/T cg13393036 chr8:95962371 TP53INP1 -0.53 -8.83 -0.44 6.38e-17 Type 2 diabetes; CRC cis rs6662572 0.703 rs7556472 chr1:46339811 G/A cg08644498 chr1:46502608 NA -0.45 -7.07 -0.36 9.42e-12 Blood protein levels; CRC cis rs2857891 0.695 rs2857895 chr11:6982992 C/G cg04053776 chr11:6947353 ZNF215 -0.39 -6.08 -0.32 3.41e-9 Response to cytadine analogues (cytosine arabinoside); CRC cis rs367615 0.537 rs17161729 chr5:108660528 C/G cg17395555 chr5:108820864 NA -0.32 -5.95 -0.31 7.02e-9 Colorectal cancer (SNP x SNP interaction); CRC cis rs4481887 0.893 rs10888348 chr1:248448610 C/G cg00666640 chr1:248458726 OR2T12 0.53 9.62 0.47 1.75e-19 Common traits (Other); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg12232852 chr3:69129018 UBA3 0.53 7.71 0.39 1.46e-13 Response to antipsychotic treatment; CRC cis rs1552244 0.882 rs7636817 chr3:10014876 G/T cg18598329 chr3:10140678 FANCD2;C3orf24 -0.82 -10.76 -0.51 2.49e-23 Alzheimer's disease; CRC cis rs4474742 1 rs4474742 chr17:28065578 A/T cg26525008 chr17:28256777 EFCAB5;SSH2 -0.72 -12.18 -0.56 2.05e-28 Monocyte count; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg21605452 chr3:176915282 TBL1XR1 0.47 6.04 0.32 4.26e-9 Thyroid stimulating hormone; CRC cis rs9910055 0.529 rs228746 chr17:42173752 T/C cg19774624 chr17:42201019 HDAC5 0.49 6.54 0.34 2.38e-10 Total body bone mineral density; CRC cis rs9549260 0.755 rs12585875 chr13:41199531 A/G cg21288729 chr13:41239152 FOXO1 0.45 7.04 0.36 1.16e-11 Red blood cell count; CRC cis rs6456156 0.792 rs10946215 chr6:167516181 A/G cg07741184 chr6:167504864 NA -0.48 -8.41 -0.42 1.28e-15 Primary biliary cholangitis; CRC cis rs7618915 0.547 rs12487591 chr3:52642936 A/T cg05573699 chr3:52720067 GNL3;PBRM1 -0.47 -6.92 -0.36 2.39e-11 Bipolar disorder; CRC cis rs2239547 0.657 rs13072536 chr3:52861211 A/T cg10802521 chr3:52805072 NEK4 -0.45 -6.0 -0.31 5.32e-9 Schizophrenia; CRC cis rs11997175 0.646 rs4733177 chr8:33691754 A/G cg04338863 chr8:33670619 NA 0.43 6.76 0.35 6.42e-11 Body mass index; CRC cis rs12701220 0.604 rs12702122 chr7:1149494 C/G cg26240231 chr7:1148101 C7orf50 -0.46 -6.69 -0.35 9.41e-11 Bronchopulmonary dysplasia; CRC cis rs7945718 0.967 rs7927470 chr11:12748899 A/T cg25843174 chr11:12811716 TEAD1 0.48 9.03 0.45 1.5e-17 Educational attainment (years of education); CRC cis rs2692947 0.599 rs7561198 chr2:96774981 C/G cg23100626 chr2:96804247 ASTL -0.29 -7.81 -0.4 7.66e-14 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; CRC cis rs10752881 0.935 rs10911235 chr1:183053746 G/A ch.1.3577855R chr1:183094577 LAMC1 0.84 14.59 0.63 1.55e-37 Colorectal cancer; CRC cis rs3824867 0.920 rs7101772 chr11:47449378 A/G cg05585544 chr11:47624801 NA 0.4 6.15 0.32 2.24e-9 Mean corpuscular hemoglobin; CRC cis rs3785574 0.962 rs56295011 chr17:61850359 A/G cg22520471 chr17:61851767 DDX42;CCDC47 0.45 6.29 0.33 1.02e-9 Height; CRC cis rs6570726 0.902 rs406979 chr6:145838983 G/T cg23711669 chr6:146136114 FBXO30 0.68 12.0 0.55 9.22e-28 Lobe attachment (rater-scored or self-reported); CRC cis rs875971 0.825 rs66981195 chr7:66079035 C/A cg00343986 chr7:65444356 GUSB -0.45 -6.17 -0.32 1.96e-9 Aortic root size; CRC cis rs58804349 0.605 rs117540287 chr10:43512040 G/T cg20628663 chr10:43360327 NA 0.58 6.76 0.35 6.33e-11 Pediatric bone mineral content (radius); CRC cis rs4862750 0.872 rs56389997 chr4:187894796 A/C cg06074448 chr4:187884817 NA -0.59 -10.92 -0.52 6.94e-24 Lobe attachment (rater-scored or self-reported); CRC trans rs1005277 0.557 rs176887 chr10:38406094 T/C cg17830980 chr10:43048298 ZNF37B -0.6 -9.93 -0.48 1.65e-20 Extrinsic epigenetic age acceleration; CRC cis rs853679 0.574 rs1233705 chr6:28166447 C/G cg15786705 chr6:28176104 NA 0.81 11.69 0.54 1.25e-26 Depression; CRC cis rs10256972 0.577 rs4999286 chr7:1199506 C/G cg18765753 chr7:1198926 ZFAND2A -0.4 -6.98 -0.36 1.63e-11 Longevity;Endometriosis; CRC cis rs9814567 0.806 rs6806810 chr3:134323522 G/A cg06109529 chr3:134205091 CEP63;ANAPC13 -0.68 -10.11 -0.49 4.11e-21 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg05314606 chr18:46478925 NA 0.42 6.06 0.32 3.74e-9 Intelligence (multi-trait analysis); CRC cis rs6860806 0.507 rs200837 chr5:131699958 G/A cg04518342 chr5:131593106 PDLIM4 0.43 6.96 0.36 1.82e-11 Breast cancer; CRC cis rs6840360 1.000 rs1896883 chr4:152595373 C/T cg09659197 chr4:152720779 NA -0.51 -10.96 -0.52 4.74e-24 Intelligence (multi-trait analysis); CRC cis rs8014671 0.597 rs1044527 chr14:70833819 C/G cg05203877 chr14:70655686 SLC8A3 -0.34 -6.64 -0.34 1.28e-10 Prostate cancer; CRC cis rs11122272 0.735 rs2474630 chr1:231535335 G/A cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.58 -8.64 -0.43 2.42e-16 Hemoglobin concentration; CRC cis rs798554 0.757 rs1182198 chr7:2862906 C/T cg13628971 chr7:2884303 GNA12 0.56 7.39 0.38 1.25e-12 Height; CRC cis rs4481887 0.962 rs5009868 chr1:248474495 A/G cg00666640 chr1:248458726 OR2T12 0.54 9.38 0.46 1.13e-18 Common traits (Other); CRC cis rs6089584 0.962 rs6142913 chr20:60566950 A/G cg23262073 chr20:60523788 NA -0.46 -7.53 -0.38 4.84e-13 Body mass index; CRC cis rs10504229 0.861 rs114700910 chr8:58170642 C/T cg02725872 chr8:58115012 NA -0.38 -6.32 -0.33 8.27e-10 Developmental language disorder (linguistic errors); CRC cis rs4727027 0.704 rs4727031 chr7:148908305 T/C cg23583168 chr7:148888333 NA -0.91 -16.47 -0.67 7.02e-45 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC cis rs2742417 1.000 rs2742390 chr3:45756722 A/G cg04837898 chr3:45731254 SACM1L 0.35 5.81 0.31 1.45e-8 Response to anti-depressant treatment in major depressive disorder; CRC cis rs9733 0.596 rs1336898 chr1:150665050 G/A cg18016565 chr1:150552671 MCL1 0.46 6.74 0.35 6.91e-11 Tonsillectomy; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg03670816 chr5:53606426 ARL15 0.35 6.25 0.33 1.29e-9 Liver disease severity in Alagille syndrome; CRC cis rs4713118 0.662 rs149970 chr6:27980220 C/T cg10876282 chr6:28092338 ZSCAN16 0.53 6.74 0.35 7.23e-11 Parkinson's disease; CRC cis rs10170846 0.861 rs4674677 chr2:223529658 G/A cg25565276 chr2:223520875 FARSB 0.47 6.39 0.33 5.61e-10 Schizophrenia (inflammation and infection response interaction); CRC cis rs875971 0.638 rs10249404 chr7:66046724 G/A cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.43 -6.32 -0.33 8.44e-10 Aortic root size; CRC cis rs391936 0.872 rs2059875 chr2:8448194 A/G cg12167548 chr2:8464763 NA 0.31 5.62 0.3 4.04e-8 Selective IgA deficiency; CRC cis rs4332037 0.851 rs34040190 chr7:1920356 G/A cg24505167 chr7:1915268 MAD1L1 -0.47 -6.44 -0.33 4.35e-10 Bipolar disorder; CRC cis rs6502050 0.805 rs7225560 chr17:80160884 C/G cg09264619 chr17:80180166 NA -0.34 -5.61 -0.3 4.4e-8 Life satisfaction; CRC cis rs9916302 0.800 rs8081220 chr17:37473157 A/C cg15445000 chr17:37608096 MED1 -0.4 -8.55 -0.43 4.85e-16 Glomerular filtration rate (creatinine); CRC trans rs875971 0.660 rs2191268 chr7:66110224 C/T cg01561839 chr1:224521239 NA -0.39 -6.35 -0.33 7.17e-10 Aortic root size; CRC cis rs10193935 0.901 rs10200000 chr2:42442212 A/G cg27598129 chr2:42591480 NA -0.69 -8.02 -0.4 1.87e-14 Colonoscopy-negative controls vs population controls; CRC cis rs853679 0.550 rs1233701 chr6:28168726 C/G cg12172441 chr6:28176163 NA -0.7 -9.5 -0.46 4.46e-19 Depression; CRC cis rs7772486 0.790 rs2253880 chr6:146200774 T/C cg13319975 chr6:146136371 FBXO30 -0.42 -6.29 -0.33 1e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs951366 0.789 rs1775154 chr1:205696615 T/A cg07167872 chr1:205819463 PM20D1 0.76 11.55 0.54 4.05e-26 Menarche (age at onset); CRC cis rs7945705 0.967 rs10769968 chr11:8907583 G/C cg00186954 chr11:8933980 ST5;C11orf17 0.47 7.38 0.38 1.33e-12 Hemoglobin concentration; CRC cis rs1799949 1.000 rs8176273 chr17:41211653 A/G cg19454999 chr17:41278357 BRCA1;NBR2 0.53 8.15 0.41 7.88e-15 Menopause (age at onset); CRC cis rs2404602 0.692 rs12913810 chr15:77166675 T/C cg22467129 chr15:76604101 ETFA -0.38 -6.07 -0.32 3.61e-9 Blood metabolite levels; CRC cis rs7666738 0.861 rs10018654 chr4:99002226 A/G cg17366294 chr4:99064904 C4orf37 0.44 7.39 0.38 1.19e-12 Colonoscopy-negative controls vs population controls; CRC cis rs10504229 0.683 rs2318148 chr8:58114955 G/A cg02290350 chr8:58132656 NA -0.58 -8.23 -0.41 4.53e-15 Developmental language disorder (linguistic errors); CRC cis rs7937682 0.921 rs10891280 chr11:111433609 A/T cg19812747 chr11:111475976 SIK2 0.49 7.28 0.37 2.51e-12 Primary sclerosing cholangitis; CRC trans rs11098499 0.775 rs67281037 chr4:120281157 G/C cg25214090 chr10:38739885 LOC399744 0.61 9.66 0.47 1.39e-19 Corneal astigmatism; CRC cis rs7586879 1.000 rs7603153 chr2:25116966 T/C cg04586622 chr2:25135609 ADCY3 -0.43 -7.19 -0.37 4.46e-12 Body mass index; CRC cis rs4820539 1.000 rs4822361 chr22:23482718 A/G cg14186256 chr22:23484241 RTDR1 -0.9 -17.9 -0.7 1.65e-50 Bone mineral density; CRC cis rs12188164 1.000 rs34847072 chr5:437862 G/C cg16322479 chr5:444228 EXOC3;C5orf55 0.48 7.84 0.4 6.19e-14 Cystic fibrosis severity; CRC cis rs71403859 0.502 rs12708914 chr16:71470636 G/A cg08717414 chr16:71523259 ZNF19 -0.58 -6.87 -0.35 3.31e-11 Post bronchodilator FEV1; CRC cis rs9549328 0.700 rs3011473 chr13:113618096 A/G cg20742385 chr13:113633654 MCF2L 0.57 9.58 0.47 2.44e-19 Systolic blood pressure; CRC cis rs6662572 0.671 rs10749861 chr1:46440252 A/C cg08644498 chr1:46502608 NA -0.46 -7.3 -0.37 2.16e-12 Blood protein levels; CRC trans rs11989744 0.597 rs2033788 chr8:23574847 G/T cg03492747 chr16:86543808 FOXF1 -0.51 -8.9 -0.44 3.95e-17 Waist-hip ratio; CRC cis rs1707322 0.963 rs11211238 chr1:46449415 G/A cg06784218 chr1:46089804 CCDC17 0.51 8.96 0.44 2.39e-17 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs1030268 0.546 rs12707100 chr7:133274376 T/C cg10665199 chr7:133106180 EXOC4 0.65 7.8 0.39 8.38e-14 Intelligence (multi-trait analysis); CRC cis rs2204008 0.870 rs12369578 chr12:38444227 C/T cg26384229 chr12:38710491 ALG10B 0.67 9.15 0.45 6.1e-18 Bladder cancer; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg07760851 chr11:695000 TMEM80;DEAF1 0.45 6.55 0.34 2.28e-10 Intelligence (multi-trait analysis); CRC cis rs3733585 0.673 rs4311316 chr4:9955971 A/C cg00071950 chr4:10020882 SLC2A9 0.53 9.31 0.46 1.89e-18 Cleft plate (environmental tobacco smoke interaction); CRC cis rs5747327 0.835 rs181396 chr22:18224155 A/G cg19898043 chr22:18121309 BCL2L13 0.37 5.65 0.3 3.45e-8 Myeloid white cell count;Granulocyte count; CRC cis rs6700896 0.931 rs10789192 chr1:66125770 G/A cg04111102 chr1:66153794 NA 0.35 6.1 0.32 3.03e-9 C-reactive protein;Mean corpuscular volume;Mean corpuscular hemoglobin; CRC cis rs4808199 1.000 rs12972397 chr19:19562349 G/A cg03709012 chr19:19516395 GATAD2A 1.03 12.44 0.57 2.21e-29 Nonalcoholic fatty liver disease; CRC cis rs4664293 0.867 rs2081723 chr2:160594160 A/G cg08347373 chr2:160653686 CD302 -0.47 -7.43 -0.38 9.32e-13 Monocyte percentage of white cells; CRC cis rs7762018 0.769 rs4716339 chr6:170063210 C/T cg24289452 chr6:170231220 NA -0.7 -7.24 -0.37 3.23e-12 Thiazide-induced adverse metabolic effects in hypertensive patients; CRC cis rs939658 0.728 rs12904323 chr15:79412583 A/C cg17916960 chr15:79447300 NA -0.41 -6.34 -0.33 7.46e-10 Refractive error; CRC cis rs7615952 0.641 rs6805074 chr3:125772274 T/A cg18479299 chr3:125709523 NA -0.55 -6.58 -0.34 1.86e-10 Blood pressure (smoking interaction); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg01080592 chr19:36248739 HSPB6;C19orf55 0.52 7.15 0.37 5.56e-12 Response to antipsychotic treatment; CRC cis rs7208859 0.623 rs9915566 chr17:29132158 G/A cg13385521 chr17:29058706 SUZ12P 0.74 8.44 0.42 9.97e-16 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs2075165 0.901 rs6701440 chr1:156249505 A/G cg20302342 chr1:156215951 PAQR6 0.38 7.23 0.37 3.35e-12 Tonsillectomy; CRC cis rs5753037 0.676 rs737945 chr22:30202774 G/C cg01021169 chr22:30184971 ASCC2 -0.4 -6.28 -0.33 1.05e-9 Type 1 diabetes; CRC cis rs6499255 0.951 rs1437136 chr16:69672675 G/C cg05250797 chr16:70222502 NA 0.41 5.69 0.3 2.78e-8 IgE levels; CRC trans rs61931739 0.534 rs11053072 chr12:34202399 A/C cg26384229 chr12:38710491 ALG10B 0.54 6.87 0.35 3.22e-11 Morning vs. evening chronotype; CRC cis rs13108904 0.901 rs7695691 chr4:1304632 A/G cg16405210 chr4:1374714 KIAA1530 -0.43 -6.11 -0.32 2.87e-9 Obesity-related traits; CRC trans rs7267979 1.000 rs4815412 chr20:25350325 A/G cg17903999 chr18:56338584 MALT1 -0.39 -6.49 -0.34 3.08e-10 Liver enzyme levels (alkaline phosphatase); CRC cis rs4363385 0.782 rs4845515 chr1:153003871 G/T cg25856811 chr1:152973957 SPRR3 -0.24 -6.69 -0.35 9.55e-11 Inflammatory skin disease; CRC cis rs2795502 0.515 rs116848302 chr10:43367783 G/A cg20628663 chr10:43360327 NA 0.73 7.8 0.4 8.07e-14 Blood protein levels; CRC cis rs769267 0.930 rs2315022 chr19:19413381 A/G cg01262667 chr19:19385393 TM6SF2 0.38 6.24 0.33 1.36e-9 Tonsillectomy; CRC cis rs970548 0.955 rs11239551 chr10:46026107 G/A cg15590007 chr10:45870220 ALOX5 0.51 6.5 0.34 3.01e-10 Total cholesterol levels;Cholesterol, total;HDL cholesterol;HDL cholesterol levels; CRC cis rs73198271 0.562 rs964772 chr8:8651306 A/G cg01851573 chr8:8652454 MFHAS1 0.54 7.0 0.36 1.48e-11 Bone ultrasound measurement (broadband ultrasound attenuation); CRC cis rs7726839 0.540 rs3792720 chr5:643028 T/G cg17948913 chr5:572064 NA 0.49 5.61 0.3 4.41e-8 Obesity-related traits; CRC cis rs4716602 0.572 rs10271030 chr7:156159796 T/C cg16983916 chr7:156159713 NA -0.39 -6.73 -0.35 7.53e-11 Anti-saccade response; CRC trans rs7757969 0.500 rs9487733 chr6:112158215 A/G cg08211895 chr2:48828358 STON1-GTF2A1L 0.31 6.07 0.32 3.57e-9 Schizophrenia; CRC cis rs57994353 0.578 rs10448340 chr9:139320069 A/C cg14119001 chr9:139324193 INPP5E -0.39 -6.22 -0.32 1.53e-9 Eosinophil counts;Cutaneous squamous cell carcinoma; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg23350889 chr12:133100618 FBRSL1 0.43 6.51 0.34 2.87e-10 Intelligence (multi-trait analysis); CRC cis rs360798 0.532 rs12994674 chr2:62996645 G/A cg17519650 chr2:63277830 OTX1 -0.42 -5.64 -0.3 3.68e-8 Coronary artery disease; CRC cis rs7089973 0.668 rs10885622 chr10:116643844 C/T cg23260525 chr10:116636907 FAM160B1 0.35 7.78 0.39 9.67e-14 Bipolar disorder or attention deficit hyperactivity disorder; CRC cis rs12760731 0.641 rs12727289 chr1:178327027 T/C cg00404053 chr1:178313656 RASAL2 0.85 10.33 0.49 7.65e-22 Obesity-related traits; CRC cis rs7909074 0.831 rs11239271 chr10:45376294 A/G cg05187965 chr10:45406764 TMEM72 -0.36 -8.53 -0.43 5.44e-16 Mean corpuscular volume; CRC trans rs629535 0.590 rs62513427 chr8:70138891 A/T cg21567404 chr3:27674614 NA -0.91 -13.22 -0.59 2.63e-32 Dupuytren's disease; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg14669749 chr1:2246478 NA 0.42 6.18 0.32 1.89e-9 Intelligence (multi-trait analysis); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg12353516 chr17:19281309 MAPK7 0.44 6.39 0.33 5.81e-10 Intelligence (multi-trait analysis); CRC cis rs7809950 0.678 rs62482499 chr7:106975059 C/G cg23024343 chr7:107201750 COG5 -0.64 -8.76 -0.43 1.03e-16 Coronary artery disease; CRC cis rs10504229 0.593 rs78459635 chr8:58004995 G/T cg21724239 chr8:58056113 NA 0.79 9.99 0.48 1.06e-20 Developmental language disorder (linguistic errors); CRC cis rs2880765 0.835 rs7180213 chr15:86021187 G/A cg17133734 chr15:86042851 AKAP13 0.42 6.79 0.35 5.35e-11 Coronary artery disease; CRC cis rs9487051 0.872 rs9480922 chr6:109607211 G/A cg21918786 chr6:109611834 NA -0.45 -8.25 -0.41 3.94e-15 Reticulocyte fraction of red cells; CRC cis rs9325144 0.555 rs4882358 chr12:38726640 A/G cg13010199 chr12:38710504 ALG10B 0.4 5.82 0.31 1.43e-8 Morning vs. evening chronotype; CRC cis rs11690935 0.549 rs2129475 chr2:172916772 A/G cg13550731 chr2:172543902 DYNC1I2 0.61 8.99 0.44 1.99e-17 Schizophrenia; CRC cis rs2836974 0.965 rs34578707 chr21:40675167 G/A cg11890956 chr21:40555474 PSMG1 0.98 15.34 0.65 1.88e-40 Cognitive function; CRC cis rs72781680 0.898 rs17462558 chr2:24020812 T/C cg08917208 chr2:24149416 ATAD2B 0.86 8.58 0.43 3.88e-16 Lymphocyte counts; CRC cis rs9534288 0.797 rs9534277 chr13:46578349 T/C cg15192986 chr13:46630673 CPB2 -0.67 -9.85 -0.48 3.16e-20 Blood protein levels; CRC cis rs2072499 0.966 rs2842869 chr1:156160696 A/G cg24450063 chr1:156163899 SLC25A44 1.15 27.61 0.84 1.1e-87 Testicular germ cell tumor; CRC cis rs4728302 0.869 rs13231079 chr7:133604373 C/G cg03336402 chr7:133662267 EXOC4 -0.45 -6.52 -0.34 2.58e-10 Intelligence;Intelligence (multi-trait analysis); CRC cis rs16975963 0.843 rs73025630 chr19:38351284 G/A cg15135657 chr19:38346511 NA -0.43 -5.76 -0.3 1.89e-8 Longevity; CRC cis rs4481887 0.927 rs4916121 chr1:248432003 C/T cg13385794 chr1:248469461 NA 0.41 7.06 0.36 9.96e-12 Common traits (Other); CRC cis rs231513 0.954 rs231512 chr17:41965831 G/A cg16892393 chr17:41919603 NA -0.54 -5.92 -0.31 8.28e-9 Cognitive function; CRC cis rs59104589 0.583 rs28386824 chr2:242349893 A/G cg19488206 chr2:242435732 STK25 0.44 6.47 0.34 3.6e-10 Fibrinogen levels; CRC trans rs7824557 0.707 rs3808518 chr8:11143272 A/C cg06636001 chr8:8085503 FLJ10661 -0.45 -6.52 -0.34 2.71e-10 Retinal vascular caliber; CRC cis rs1215050 0.791 rs260893 chr4:98744785 A/C cg05340658 chr4:99064831 C4orf37 0.47 6.88 0.35 3.09e-11 Waist-to-hip ratio adjusted for body mass index; CRC cis rs7772486 0.686 rs1337841 chr6:146059487 A/G cg23711669 chr6:146136114 FBXO30 -0.66 -11.09 -0.52 1.75e-24 Lobe attachment (rater-scored or self-reported); CRC cis rs737337 0.623 rs12463177 chr19:11341680 G/C cg00586551 chr19:11347513 LOC55908;DOCK6 0.82 9.12 0.45 7.86e-18 HDL cholesterol;HDL cholesterol levels; CRC cis rs2836974 0.897 rs2836973 chr21:40654928 A/G cg17971929 chr21:40555470 PSMG1 0.86 12.94 0.58 3.02e-31 Cognitive function; CRC cis rs4862750 0.872 rs6553030 chr4:187899234 T/C cg22105103 chr4:187893119 NA 0.64 11.71 0.54 1.01e-26 Lobe attachment (rater-scored or self-reported); CRC cis rs62229266 0.804 rs998383 chr21:37445739 C/G cg08632701 chr21:37451849 NA -0.44 -6.89 -0.36 2.78e-11 Mitral valve prolapse; CRC cis rs6961069 0.749 rs1537477 chr7:80251202 A/C cg04458919 chr7:80252533 CD36 0.36 6.46 0.34 3.86e-10 Platelet count; CRC cis rs763014 0.966 rs4984675 chr16:670117 T/C cg03804128 chr16:635623 NA 0.3 6.82 0.35 4.31e-11 Height; CRC cis rs10256972 0.552 rs7805591 chr7:1210745 A/G cg18402987 chr7:1209562 NA 0.57 8.61 0.43 3.05e-16 Longevity;Endometriosis; CRC cis rs8099014 0.559 rs9319928 chr18:56099996 T/G cg19312305 chr18:56117016 MIR122 -0.43 -5.95 -0.31 7e-9 Platelet count; CRC cis rs7625357 0.964 rs7652404 chr3:169352458 A/G cg04414509 chr3:169351419 MECOM 0.6 8.44 0.42 1e-15 Childhood and early adolescence aggressive behavior; CRC cis rs9309711 0.643 rs4535074 chr2:3481637 A/G cg08493051 chr2:3487164 NA -0.39 -5.63 -0.3 3.79e-8 Neurofibrillary tangles; CRC cis rs10750766 1 rs10750766 chr11:65473798 C/A cg27068330 chr11:65405492 SIPA1 -0.48 -6.08 -0.32 3.24e-9 High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count;Immature fraction of reticulocytes; CRC cis rs644799 0.930 rs631099 chr11:95563482 T/C cg25622487 chr11:95524042 FAM76B;CEP57 0.76 11.99 0.55 9.59e-28 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg04799218 chr12:7125780 LPCAT3 0.52 7.23 0.37 3.36e-12 Anxiety disorder; CRC cis rs17092148 0.652 rs76324086 chr20:33079392 T/G cg08999081 chr20:33150536 PIGU -0.46 -5.71 -0.3 2.5e-8 Neuroticism; CRC cis rs6582630 0.519 rs8189618 chr12:38276281 A/C cg26384229 chr12:38710491 ALG10B 0.67 9.01 0.44 1.77e-17 Drug-induced liver injury (flucloxacillin); CRC cis rs10504229 0.545 rs56394419 chr8:58128982 T/C cg05313129 chr8:58192883 C8orf71 -0.43 -6.11 -0.32 2.74e-9 Developmental language disorder (linguistic errors); CRC cis rs77633900 0.772 rs2957611 chr15:76704878 C/T cg21673338 chr15:77095150 SCAPER -0.66 -5.62 -0.3 4.15e-8 Non-glioblastoma glioma;Glioma; CRC cis rs6142102 0.961 rs2300204 chr20:32588773 G/A cg08999081 chr20:33150536 PIGU 0.37 5.64 0.3 3.69e-8 Skin pigmentation; CRC cis rs12024301 0.557 rs78324977 chr1:183598882 C/T cg11505048 chr1:183622726 RGL1;APOBEC4 0.76 6.95 0.36 1.92e-11 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs13118159 0.509 rs10023473 chr4:1375285 C/T cg19318889 chr4:1322082 MAEA 0.65 9.75 0.47 6.97e-20 Longevity; CRC cis rs12497850 0.931 rs7627404 chr3:48819668 A/C cg07636037 chr3:49044803 WDR6 1.01 17.62 0.7 2.11e-49 Parkinson's disease; CRC trans rs783540 0.967 rs1864699 chr15:83323318 A/G cg18393722 chr15:85113863 UBE2QP1 0.37 6.1 0.32 2.98e-9 Schizophrenia; CRC cis rs28386778 0.897 rs1470697 chr17:61799840 T/C cg23090583 chr17:61904693 PSMC5;FTSJ3 1.03 19.28 0.73 5.63e-56 Prudent dietary pattern; CRC trans rs1656966 1.000 rs1656966 chr3:186466252 C/T cg21611145 chr19:13261629 IER2;STX10 0.39 6.02 0.31 4.72e-9 Myopia (pathological); CRC cis rs3789045 0.729 rs16853822 chr1:204450341 C/G cg17419461 chr1:204415978 PIK3C2B -0.61 -8.47 -0.42 8.41e-16 Educational attainment (college completion); CRC cis rs6604026 0.922 rs1854797 chr1:93298756 T/C cg17283838 chr1:93427260 FAM69A 0.45 5.77 0.3 1.83e-8 Multiple sclerosis; CRC cis rs1712517 0.835 rs2506961 chr10:105007926 G/T cg05636881 chr10:105038444 INA -0.49 -8.81 -0.44 7.1e-17 Migraine; CRC cis rs10193935 0.901 rs10490552 chr2:42559947 C/T cg27598129 chr2:42591480 NA 0.52 6.65 0.34 1.21e-10 Colonoscopy-negative controls vs population controls; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg27486582 chr12:120884061 TRIAP1;GATC 0.48 6.9 0.36 2.66e-11 Intelligence (multi-trait analysis); CRC cis rs9381040 0.610 rs2235679 chr6:41020577 G/T cg04346459 chr6:41068666 NFYA;LOC221442 -0.41 -6.2 -0.32 1.67e-9 Alzheimer's disease (late onset); CRC cis rs73206853 0.620 rs111354540 chr12:111150302 A/G cg12870014 chr12:110450643 ANKRD13A 0.67 6.47 0.34 3.66e-10 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC cis rs9611565 0.649 rs5758344 chr22:41817685 G/A cg06634786 chr22:41940651 POLR3H 0.7 7.85 0.4 6.01e-14 Vitiligo; CRC cis rs13108904 0.870 rs4974543 chr4:1251222 A/G cg02018176 chr4:1364513 KIAA1530 0.45 7.56 0.38 4.03e-13 Obesity-related traits; CRC trans rs2727020 0.729 rs1917325 chr11:49370004 G/A cg03929089 chr4:120376271 NA -0.83 -14.65 -0.63 9.06e-38 Coronary artery disease; CRC cis rs6088580 0.634 rs2378133 chr20:32919505 C/G cg08999081 chr20:33150536 PIGU -0.62 -11.49 -0.54 6.32e-26 Glomerular filtration rate (creatinine); CRC cis rs28386778 0.863 rs7221573 chr17:61859390 G/A cg06873352 chr17:61820015 STRADA 0.77 14.5 0.62 3.51e-37 Prudent dietary pattern; CRC cis rs875971 0.838 rs2173570 chr7:65762963 T/A cg00343986 chr7:65444356 GUSB -0.43 -6.21 -0.32 1.56e-9 Aortic root size; CRC cis rs1223397 0.651 rs2458314 chr6:13309224 C/T cg06879394 chr6:13274151 PHACTR1 0.37 5.63 0.3 3.84e-8 Blood pressure; CRC cis rs9902453 0.715 rs2628176 chr17:28139292 A/T cg26525008 chr17:28256777 EFCAB5;SSH2 -0.63 -10.02 -0.48 8.67e-21 Coffee consumption (cups per day); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg02076414 chr1:47779921 STIL 0.42 6.3 0.33 9.77e-10 Response to antipsychotic treatment; CRC cis rs870825 0.616 rs6843185 chr4:185649878 A/C cg04058563 chr4:185651563 MLF1IP 0.71 9.27 0.46 2.47e-18 Blood protein levels; CRC trans rs9467711 0.659 rs3823158 chr6:26463271 T/A cg06606381 chr12:133084897 FBRSL1 -1.1 -7.57 -0.39 3.74e-13 Autism spectrum disorder or schizophrenia; CRC cis rs2836974 0.897 rs2836933 chr21:40564202 C/G cg11890956 chr21:40555474 PSMG1 1.09 18.53 0.71 5.18e-53 Cognitive function; CRC cis rs12142240 0.698 rs10158130 chr1:46822600 T/C cg14993813 chr1:46806288 NSUN4 -0.49 -6.22 -0.32 1.55e-9 Menopause (age at onset); CRC cis rs4588572 0.644 rs6873144 chr5:77741784 C/T cg11547950 chr5:77652471 NA -0.49 -7.1 -0.36 7.7e-12 Triglycerides; CRC cis rs12431939 1.000 rs56220306 chr14:51648738 A/T cg23942311 chr14:51606299 NA -0.53 -6.11 -0.32 2.75e-9 Cancer; CRC cis rs7258465 1.000 rs34256197 chr19:18606472 G/A cg06462663 chr19:18546047 ISYNA1 0.48 7.26 0.37 2.73e-12 Breast cancer; CRC cis rs910187 0.572 rs6018325 chr20:45810335 A/G cg27589058 chr20:45804311 EYA2 -0.4 -7.69 -0.39 1.67e-13 Migraine; CRC cis rs7680126 0.633 rs2024280 chr4:10291813 A/G cg00071950 chr4:10020882 SLC2A9 -0.5 -6.45 -0.34 3.98e-10 Urate levels in lean individuals;Urate levels in overweight individuals;Urate levels in obese individuals; CRC cis rs7904368 0.806 rs6602161 chr10:16862280 A/G cg14835575 chr10:16859367 RSU1 0.46 6.31 0.33 9.1e-10 Ratio of the peak velocity of the mitral E-Wave divided by the peak velocity of the mitral A-wave.; CRC trans rs6550704 0.687 rs9865314 chr3:22634337 A/G cg05824432 chr16:2301222 DCI -0.42 -6.08 -0.32 3.28e-9 Daytime sleep phenotypes; CRC cis rs600806 0.893 rs370088 chr1:109858119 T/C cg23032129 chr1:109941072 SORT1 -0.27 -5.8 -0.3 1.59e-8 Intelligence (multi-trait analysis); CRC cis rs9467773 1.000 rs9393728 chr6:26509330 C/G cg09904177 chr6:26538194 HMGN4 0.85 14.75 0.63 3.95e-38 Intelligence (multi-trait analysis); CRC cis rs9659323 0.539 rs1750331 chr1:119494973 A/G cg05756136 chr1:119680316 WARS2 -0.39 -5.63 -0.3 3.89e-8 Body mass index; CRC cis rs4588572 0.643 rs6874309 chr5:77774498 A/T cg11446398 chr5:77624930 NA -0.45 -6.22 -0.32 1.49e-9 Triglycerides; CRC cis rs6860806 0.661 rs6890009 chr5:131580033 G/T cg04518342 chr5:131593106 PDLIM4 0.43 7.82 0.4 7.22e-14 Breast cancer; CRC cis rs9611565 0.765 rs9607800 chr22:41784562 A/G cg03806693 chr22:41940476 POLR3H -1.01 -12.7 -0.57 2.36e-30 Vitiligo; CRC cis rs7043114 0.525 rs7020874 chr9:95112560 G/A cg13798575 chr9:95087839 CENPP;NOL8 -0.39 -5.83 -0.31 1.36e-8 Height; CRC cis rs8067545 0.750 rs11870111 chr17:19992738 G/A cg13482628 chr17:19912719 NA 0.46 7.55 0.38 4.46e-13 Schizophrenia; CRC cis rs67311347 0.544 rs35112505 chr3:40337075 A/G cg09455208 chr3:40491958 NA 0.31 6.31 0.33 8.76e-10 Renal cell carcinoma; CRC cis rs713587 0.776 rs1172294 chr2:25169200 A/G cg04586622 chr2:25135609 ADCY3 -0.35 -6.02 -0.31 4.74e-9 Body mass index in non-asthmatics; CRC cis rs10504229 1.000 rs67913746 chr8:58177825 A/G cg02725872 chr8:58115012 NA -0.38 -6.43 -0.33 4.44e-10 Developmental language disorder (linguistic errors); CRC cis rs9858542 0.953 rs6809216 chr3:49412559 G/A cg00383909 chr3:49044727 WDR6 0.43 5.65 0.3 3.45e-8 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs311392 0.867 rs364484 chr8:55093492 G/T cg20636351 chr8:55087400 NA -0.33 -5.96 -0.31 6.62e-9 Pelvic organ prolapse (moderate/severe); CRC cis rs2576037 0.796 rs2247021 chr18:44578794 A/C cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.43 -6.38 -0.33 6.02e-10 Personality dimensions; CRC cis rs765787 0.530 rs28897155 chr15:45533974 T/C cg24006582 chr15:45444508 DUOX1 -0.57 -8.79 -0.44 8.5e-17 Uric acid levels; CRC cis rs743757 1.000 rs2236987 chr3:50504546 C/T cg08207895 chr3:50388901 TUSC4;CYB561D2 -0.4 -5.71 -0.3 2.5e-8 Diastolic blood pressure; CRC cis rs4819052 0.851 rs13049337 chr21:46663460 T/G cg11663144 chr21:46675770 NA -0.83 -14.3 -0.62 1.99e-36 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs9814567 1.000 rs11706117 chr3:134212526 T/C cg06109529 chr3:134205091 CEP63;ANAPC13 -0.83 -12.17 -0.56 2.2e-28 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC trans rs1005277 0.579 rs2505248 chr10:38459097 A/G cg11292332 chr7:45801988 SEPT13 -0.35 -6.27 -0.33 1.13e-9 Extrinsic epigenetic age acceleration; CRC cis rs28386778 0.742 rs3020617 chr17:61947303 A/G cg25654072 chr17:61904446 PSMC5;FTSJ3 0.71 10.89 0.51 8.75e-24 Prudent dietary pattern; CRC cis rs4843747 0.636 rs4075597 chr16:88107590 C/A cg17633681 chr16:88106987 BANP 0.87 15.42 0.65 9.15e-41 Menopause (age at onset); CRC trans rs634534 0.562 rs1151505 chr11:65734539 C/T cg17712092 chr4:129076599 LARP1B 0.62 10.15 0.49 3.12e-21 Sum eosinophil basophil counts;Eosinophil counts; CRC trans rs4869931 0.929 rs9480530 chr6:151006962 A/T cg01367992 chr1:160766535 LY9 0.37 5.99 0.31 5.6e-9 Systolic blood pressure in sickle cell anemia; CRC cis rs11098499 0.954 rs11734241 chr4:120416872 A/G cg09307838 chr4:120376055 NA 0.72 11.05 0.52 2.45e-24 Corneal astigmatism; CRC cis rs12431939 0.598 rs7144511 chr14:51740243 A/G cg23942311 chr14:51606299 NA 0.47 6.41 0.33 5.11e-10 Cancer; CRC cis rs7412746 0.611 rs9661876 chr1:150910911 C/T cg17724175 chr1:150552817 MCL1 0.4 6.14 0.32 2.37e-9 Melanoma; CRC cis rs155076 0.711 rs4769158 chr13:21881975 T/C cg25811766 chr13:21894605 NA 0.57 6.77 0.35 5.88e-11 White matter hyperintensity burden; CRC cis rs6804368 0.553 rs9829308 chr3:30763073 A/C cg06106510 chr3:30762233 NA 0.39 6.29 0.33 1.02e-9 Blood metabolite levels; CRC trans rs4650994 0.525 rs4651000 chr1:178532223 A/G cg05059571 chr16:84539110 KIAA1609 -0.55 -7.73 -0.39 1.3e-13 HDL cholesterol levels;HDL cholesterol; CRC cis rs67478160 0.643 rs2295141 chr14:104212949 T/C cg08213375 chr14:104286397 PPP1R13B 0.65 13.79 0.61 1.92e-34 Schizophrenia; CRC cis rs250677 1.000 rs36082 chr5:148428844 C/G cg23229984 chr5:148520753 ABLIM3 0.53 7.12 0.37 6.7e-12 Breast cancer; CRC cis rs5167 0.504 rs7259679 chr19:45457306 C/T cg13119609 chr19:45449297 APOC2 0.31 5.85 0.31 1.19e-8 Blood protein levels; CRC cis rs17376456 0.877 rs10055340 chr5:93317644 T/C cg09848695 chr5:92956644 FAM172A;MIR2277 0.64 5.92 0.31 8.24e-9 Diabetic retinopathy; CRC cis rs9420 0.961 rs11604325 chr11:57497011 C/A cg23127183 chr11:57508653 C11orf31 -0.53 -7.16 -0.37 5.32e-12 Schizophrenia; CRC cis rs9611519 1.000 rs5758268 chr22:41622419 A/T cg03806693 chr22:41940476 POLR3H -0.48 -6.21 -0.32 1.6e-9 Neuroticism; CRC cis rs28386778 0.897 rs2727290 chr17:61894728 G/T cg11494091 chr17:61959527 GH2 0.6 10.1 0.49 4.51e-21 Prudent dietary pattern; CRC trans rs10504229 1.000 rs56350499 chr8:58178139 C/T cg04077850 chr5:125800366 GRAMD3 0.37 6.27 0.33 1.15e-9 Developmental language disorder (linguistic errors); CRC cis rs1552244 0.572 rs3894321 chr3:10168892 A/C cg16606324 chr3:10149918 C3orf24 0.69 8.17 0.41 6.69e-15 Alzheimer's disease; CRC cis rs6502050 0.769 rs4789741 chr17:80119184 A/C cg22110888 chr17:80059540 CCDC57 0.41 6.47 0.34 3.51e-10 Life satisfaction; CRC cis rs13315871 1.000 rs4367085 chr3:58389235 A/G cg20936604 chr3:58311152 NA -0.71 -6.59 -0.34 1.75e-10 Cholesterol, total; CRC cis rs7618501 0.602 rs2624816 chr3:50117312 T/G cg24308560 chr3:49941425 MST1R 0.5 8.23 0.41 4.39e-15 Intelligence (multi-trait analysis); CRC cis rs9398803 0.865 rs9375442 chr6:126803137 A/C cg19875578 chr6:126661172 C6orf173 0.43 5.99 0.31 5.61e-9 Male-pattern baldness; CRC cis rs736408 0.540 rs4687637 chr3:52634092 C/T cg14092988 chr3:52407081 DNAH1 0.29 5.61 0.3 4.29e-8 Bipolar disorder; CRC cis rs7312933 0.558 rs2178753 chr12:42732804 T/C cg11827402 chr12:42719852 PPHLN1;ZCRB1 -0.66 -9.53 -0.47 3.53e-19 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CRC cis rs12451471 0.500 rs8077056 chr17:78076006 C/T cg21238619 chr17:78079768 GAA -0.34 -5.62 -0.3 4.08e-8 Plateletcrit;Mean corpuscular hemoglobin concentration; CRC trans rs9929218 0.953 rs34909703 chr16:68740097 T/C cg04657470 chr2:198365150 HSPE1;HSPD1 -0.97 -14.27 -0.62 2.67e-36 Colorectal cancer; CRC trans rs2727020 0.521 rs7930855 chr11:49521660 C/T cg03929089 chr4:120376271 NA 0.76 10.11 0.49 4.18e-21 Coronary artery disease; CRC cis rs7202877 0.706 rs8055609 chr16:75402088 C/T cg03315344 chr16:75512273 CHST6 0.5 5.9 0.31 8.85e-9 Type 2 diabetes;Type 1 diabetes; CRC cis rs2842992 0.915 rs2842958 chr6:160108425 A/G cg19482086 chr6:160211437 TCP1;MRPL18 0.69 8.6 0.43 3.33e-16 Age-related macular degeneration (geographic atrophy); CRC cis rs6964587 0.655 rs6965864 chr7:91595596 A/G cg17063962 chr7:91808500 NA 0.62 10.03 0.48 7.92e-21 Breast cancer; CRC cis rs2836974 0.897 rs34035316 chr21:40594023 T/C cg17971929 chr21:40555470 PSMG1 0.82 11.69 0.54 1.24e-26 Cognitive function; CRC cis rs40363 0.723 rs8060367 chr16:3537919 C/A cg05754148 chr16:3507555 NAT15 -0.7 -6.85 -0.35 3.65e-11 Tuberculosis; CRC cis rs6582630 0.519 rs12582285 chr12:38298753 C/T cg26384229 chr12:38710491 ALG10B 0.69 9.77 0.47 5.73e-20 Drug-induced liver injury (flucloxacillin); CRC trans rs79464052 0.826 rs76686252 chr5:141012013 G/A cg05255351 chr5:1503979 LPCAT1 -0.56 -6.87 -0.35 3.22e-11 Diffuse large B cell lymphoma; CRC cis rs13256369 0.951 rs13260947 chr8:8565883 A/G cg06636001 chr8:8085503 FLJ10661 0.46 5.91 0.31 8.32e-9 Obesity-related traits; CRC trans rs10504229 1.000 rs72650892 chr8:58179714 A/G cg04077850 chr5:125800366 GRAMD3 0.37 6.27 0.33 1.15e-9 Developmental language disorder (linguistic errors); CRC cis rs1707322 0.686 rs2230658 chr1:46078854 A/G cg03146154 chr1:46216737 IPP -0.69 -9.82 -0.48 3.89e-20 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs2380220 0.872 rs66723559 chr6:95956338 T/C cg04719120 chr6:96025338 MANEA -0.55 -6.04 -0.32 4.15e-9 Behavioural disinhibition (generation interaction); CRC cis rs2032447 0.839 rs199750 chr6:26016462 A/G cg12310025 chr6:25882481 NA 0.52 7.3 0.37 2.16e-12 Intelligence (multi-trait analysis); CRC cis rs754466 0.580 rs1058198 chr10:79566632 G/A cg17075019 chr10:79541650 NA -0.93 -17.29 -0.69 4.36e-48 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs17376456 0.825 rs72786702 chr5:93254656 A/C cg21475434 chr5:93447410 FAM172A 0.83 8.24 0.41 4.04e-15 Diabetic retinopathy; CRC cis rs35883536 0.626 rs11799819 chr1:101049382 G/A cg06223162 chr1:101003688 GPR88 -0.34 -6.02 -0.31 4.73e-9 Monocyte count; CRC cis rs9534288 0.783 rs1126366 chr13:46633148 C/G cg15192986 chr13:46630673 CPB2 -0.78 -10.96 -0.52 5.02e-24 Blood protein levels; CRC cis rs7584330 0.518 rs7561919 chr2:238435241 A/G cg14458575 chr2:238380390 NA 0.76 9.77 0.47 5.98e-20 Prostate cancer; CRC cis rs7615952 0.576 rs4646748 chr3:125826329 G/A cg18479299 chr3:125709523 NA -0.56 -6.73 -0.35 7.71e-11 Blood pressure (smoking interaction); CRC cis rs8062405 0.691 rs11646653 chr16:28922149 C/T cg16576597 chr16:28551801 NUPR1 -0.45 -6.39 -0.33 5.59e-10 Cognitive ability (multi-trait analysis);Cognitive ability; CRC cis rs6502050 0.865 rs8079388 chr17:80162798 C/A cg02741985 chr17:80059408 CCDC57 0.44 7.28 0.37 2.55e-12 Life satisfaction; CRC cis rs9527 0.571 rs12765337 chr10:104635344 G/C cg15744005 chr10:104629667 AS3MT -0.38 -7.69 -0.39 1.72e-13 Arsenic metabolism; CRC cis rs9611565 0.644 rs2413652 chr22:42097238 C/T cg03806693 chr22:41940476 POLR3H 0.69 9.6 0.47 2.06e-19 Vitiligo; CRC trans rs2228479 0.618 rs34689166 chr16:89860697 C/T cg24644049 chr4:85504048 CDS1 0.83 6.97 0.36 1.69e-11 Skin colour saturation; CRC cis rs9522267 0.511 rs4773397 chr13:112245044 T/C cg26182253 chr13:112236782 NA 0.3 5.95 0.31 6.91e-9 Hepatitis; CRC trans rs1005277 0.579 rs2472178 chr10:38384750 T/C cg27523141 chr10:43048294 ZNF37B 0.49 7.38 0.38 1.32e-12 Extrinsic epigenetic age acceleration; CRC cis rs8180040 0.966 rs34634681 chr3:47579102 G/A cg02527881 chr3:46936655 PTH1R 0.36 6.28 0.33 1.05e-9 Colorectal cancer; CRC cis rs17818399 0.749 rs35625984 chr2:46805908 A/G cg21681030 chr2:46777652 RHOQ 0.44 6.18 0.32 1.93e-9 Height; CRC cis rs9902453 0.934 rs7213902 chr17:28322935 C/T cg26525008 chr17:28256777 EFCAB5;SSH2 0.58 8.75 0.43 1.13e-16 Coffee consumption (cups per day); CRC cis rs1971762 0.561 rs4759288 chr12:54084006 T/A cg06632207 chr12:54070931 ATP5G2 0.41 7.09 0.36 8.46e-12 Height; CRC cis rs4481887 1.000 rs7553333 chr1:248493956 C/G cg00666640 chr1:248458726 OR2T12 0.54 9.36 0.46 1.28e-18 Common traits (Other); CRC cis rs754466 0.580 rs1866437 chr10:79526766 A/G cg26805224 chr10:79626177 DLG5 -0.51 -7.46 -0.38 7.85e-13 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs57221529 0.825 rs72703051 chr5:582997 G/A cg14541582 chr5:601475 NA -0.37 -6.71 -0.35 8.52e-11 Lung disease severity in cystic fibrosis; CRC cis rs4474465 0.790 rs4492845 chr11:78260161 C/T cg27205649 chr11:78285834 NARS2 0.5 6.42 0.33 4.77e-10 Alzheimer's disease (survival time); CRC cis rs9322193 0.923 rs3798761 chr6:150004779 A/G cg13206674 chr6:150067644 NUP43 0.65 9.76 0.47 6.08e-20 Lung cancer; CRC cis rs1580019 0.961 rs4320456 chr7:32496003 T/C cg07520158 chr7:32535189 LSM5;AVL9 0.45 6.48 0.34 3.4e-10 Cognitive ability; CRC cis rs34172651 0.571 rs9922156 chr16:24704329 C/A cg00339695 chr16:24857497 SLC5A11 -0.36 -7.5 -0.38 6.17e-13 Intelligence (multi-trait analysis); CRC cis rs6693567 0.526 rs698918 chr1:150319762 A/G cg15654264 chr1:150340011 RPRD2 0.37 5.81 0.31 1.46e-8 Migraine; CRC cis rs1865760 0.566 rs10807006 chr6:26048752 C/A cg17691542 chr6:26056736 HIST1H1C 0.55 8.25 0.41 3.86e-15 Height; CRC cis rs2840044 1.000 rs225295 chr17:33925755 A/G cg05299278 chr17:33885742 SLFN14 0.4 6.09 0.32 3.16e-9 Response to radiotherapy in cancer (late toxicity); CRC cis rs10504229 0.681 rs11779172 chr8:58045538 A/G cg22535103 chr8:58192502 C8orf71 -0.52 -6.34 -0.33 7.44e-10 Developmental language disorder (linguistic errors); CRC cis rs12900463 0.813 rs186266 chr15:85402795 A/G cg11189052 chr15:85197271 WDR73 0.46 6.35 0.33 7.23e-10 Adverse response to chemotherapy (neutropenia/leucopenia) (gemcitabine); CRC cis rs4689388 0.856 rs1046314 chr4:6303955 A/G cg14416269 chr4:6271139 WFS1 -0.38 -6.13 -0.32 2.49e-9 Type 2 diabetes and other traits;Type 2 diabetes; CRC cis rs9549328 0.643 rs4907567 chr13:113617533 C/T cg25790453 chr13:113633590 MCF2L 0.44 7.62 0.39 2.7e-13 Systolic blood pressure; CRC cis rs6461049 0.765 rs10224497 chr7:2149967 A/G cg14004847 chr7:1930337 MAD1L1 -0.4 -5.73 -0.3 2.3e-8 Schizophrenia; CRC cis rs1862618 0.671 rs2591956 chr5:56244604 G/A cg20203395 chr5:56204925 C5orf35 0.57 7.89 0.4 4.39e-14 Initial pursuit acceleration; CRC cis rs832540 0.629 rs10940512 chr5:56082094 G/C cg20203395 chr5:56204925 C5orf35 -0.47 -6.44 -0.33 4.15e-10 Coronary artery disease; CRC cis rs10992471 0.580 rs10992366 chr9:95317214 G/A cg14631576 chr9:95140430 CENPP -0.38 -6.63 -0.34 1.36e-10 Visceral adipose tissue/subcutaneous adipose tissue ratio; CRC cis rs1784581 0.588 rs9885762 chr6:162411954 G/A cg17173639 chr6:162384350 PARK2 0.6 9.75 0.47 6.86e-20 Itch intensity from mosquito bite; CRC cis rs7666738 0.830 rs1834645 chr4:98979593 T/A cg17366294 chr4:99064904 C4orf37 0.43 7.35 0.38 1.57e-12 Colonoscopy-negative controls vs population controls; CRC cis rs7692995 1.000 rs6828122 chr4:18006052 A/G cg08925142 chr4:18023851 LCORL -0.55 -6.06 -0.32 3.73e-9 Height; CRC cis rs7493 1.000 rs17876123 chr7:95045307 C/A cg04155289 chr7:94953770 PON1 -0.62 -7.74 -0.39 1.23e-13 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs72720396 0.789 rs12048450 chr1:91199660 G/A cg13456504 chr1:91191583 NA 0.44 5.89 0.31 9.7e-9 Morning vs. evening chronotype;Chronotype; CRC cis rs7223966 1.000 rs8081541 chr17:61812483 C/T cg05941027 chr17:61774174 LIMD2 0.36 6.41 0.33 4.96e-10 Hip circumference adjusted for BMI;Body mass index; CRC cis rs34172651 0.517 rs11639856 chr16:24788645 A/T cg06505273 chr16:24850292 NA -0.47 -5.87 -0.31 1.05e-8 Intelligence (multi-trait analysis); CRC cis rs7959452 0.684 rs11177615 chr12:69754189 G/A cg22834771 chr12:69754056 YEATS4 -0.5 -7.33 -0.37 1.84e-12 Blood protein levels; CRC cis rs870825 0.860 rs72689297 chr4:185600957 A/T cg04058563 chr4:185651563 MLF1IP 0.63 6.52 0.34 2.71e-10 Blood protein levels; CRC cis rs10504229 0.683 rs55868006 chr8:58135703 C/T cg05313129 chr8:58192883 C8orf71 -0.43 -6.11 -0.32 2.74e-9 Developmental language disorder (linguistic errors); CRC cis rs1348850 0.526 rs10930797 chr2:178437553 C/G cg27490568 chr2:178487706 NA 0.66 7.78 0.39 9.4e-14 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs1799949 0.965 rs8067269 chr17:41235799 C/T cg05368731 chr17:41323189 NBR1 0.56 8.3 0.42 2.7e-15 Menopause (age at onset); CRC cis rs172166 0.516 rs2021826 chr6:28132756 G/A cg10876282 chr6:28092338 ZSCAN16 0.4 5.7 0.3 2.67e-8 Cardiac Troponin-T levels; CRC cis rs875971 0.825 rs7384021 chr7:66077904 A/G cg11764359 chr7:65958608 NA -0.59 -8.76 -0.43 1.09e-16 Aortic root size; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg13794888 chr15:75917792 SNUPN 0.49 6.45 0.34 4.09e-10 Thyroid stimulating hormone; CRC trans rs1814175 0.645 rs28454367 chr11:50045708 G/A cg11707556 chr5:10655725 ANKRD33B -0.52 -10.16 -0.49 2.82e-21 Height; CRC cis rs7618501 0.633 rs9814664 chr3:50078541 C/T cg24308560 chr3:49941425 MST1R 0.53 8.84 0.44 5.87e-17 Intelligence (multi-trait analysis); CRC cis rs7216064 0.954 rs4790974 chr17:65951107 A/T cg12091567 chr17:66097778 LOC651250 0.64 8.05 0.41 1.53e-14 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CRC cis rs9611565 0.659 rs9611602 chr22:41908405 T/C cg06481639 chr22:41940642 POLR3H -0.54 -6.3 -0.33 9.65e-10 Vitiligo; CRC cis rs875971 0.545 rs1796222 chr7:66057154 T/C cg18876405 chr7:65276391 NA -0.46 -6.34 -0.33 7.38e-10 Aortic root size; CRC trans rs800082 0.505 rs920148 chr3:144246677 A/C cg24215973 chr2:240111563 HDAC4 0.46 6.51 0.34 2.87e-10 Smoking behavior; CRC cis rs1983891 0.908 rs2148342 chr6:41519522 G/A cg20194872 chr6:41519635 FOXP4 0.4 5.86 0.31 1.14e-8 Prostate cancer; CRC cis rs270601 0.683 rs81598 chr5:131587960 C/G cg09877947 chr5:131593287 PDLIM4 0.55 9.42 0.46 8.11e-19 Acylcarnitine levels; CRC cis rs270601 0.770 rs4361510 chr5:131599647 C/T cg11843238 chr5:131593191 PDLIM4 0.49 9.29 0.46 2.11e-18 Acylcarnitine levels; CRC cis rs60843830 0.662 rs6721594 chr2:305203 C/T cg00108164 chr2:264199 ACP1;SH3YL1 -0.52 -7.65 -0.39 2.22e-13 Spherical equivalent (joint analysis main effects and education interaction); CRC cis rs12505749 0.660 rs7690100 chr4:57344320 C/A cg06922635 chr4:57371607 ARL9 -0.55 -5.72 -0.3 2.34e-8 Airflow obstruction; CRC cis rs7927771 1.000 rs35902101 chr11:47795169 C/T cg05585544 chr11:47624801 NA -0.62 -10.82 -0.51 1.47e-23 Subjective well-being; CRC cis rs4665809 0.652 rs10779956 chr2:26405985 A/G cg04944784 chr2:26401820 FAM59B -0.86 -10.95 -0.52 5.39e-24 Gut microbiome composition (summer); CRC trans rs4263408 0.934 rs9683743 chr4:39703194 A/C cg17958798 chr17:7200008 NA -0.42 -6.45 -0.34 3.97e-10 Plasma amyloid beta peptide concentrations (ABx-40); CRC cis rs2404602 1.000 rs2404741 chr15:76851735 C/T cg03037974 chr15:76606532 NA 0.65 11.09 0.52 1.77e-24 Blood metabolite levels; CRC cis rs4555082 0.834 rs2975217 chr14:105710238 A/C cg10792982 chr14:105748885 BRF1 0.35 5.76 0.3 1.93e-8 Mean platelet volume;Platelet distribution width; CRC cis rs12477438 0.798 rs9808541 chr2:99642179 A/T cg26064155 chr2:99771622 LIPT1;TSGA10 -0.79 -11.26 -0.53 4.29e-25 Chronic sinus infection; CRC cis rs4819052 0.851 rs2838855 chr21:46680566 C/G cg19498844 chr21:46707878 POFUT2;LOC642852 -0.75 -10.94 -0.52 5.8e-24 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs644799 0.672 rs11021307 chr11:95501407 C/T cg25622487 chr11:95524042 FAM76B;CEP57 0.79 13.03 0.58 1.44e-31 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs4718428 0.705 rs68168107 chr7:66255238 G/A cg18252515 chr7:66147081 NA -0.54 -7.36 -0.38 1.46e-12 Corneal structure; CRC cis rs12586317 0.548 rs12590678 chr14:35602956 C/T cg16230307 chr14:35515116 FAM177A1 0.72 8.03 0.4 1.71e-14 Psoriasis; CRC cis rs4808199 0.895 rs10421505 chr19:19459554 C/T cg26732615 chr19:19648335 CILP2;YJEFN3 0.45 5.84 0.31 1.28e-8 Nonalcoholic fatty liver disease; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg08845439 chr1:151512945 TUFT1 -0.4 -5.98 -0.31 5.92e-9 Myopia (pathological); CRC cis rs8016982 0.657 rs8021125 chr14:81704787 C/T cg01989461 chr14:81687754 GTF2A1 -0.54 -8.44 -0.42 9.96e-16 Schizophrenia; CRC cis rs990171 0.955 rs6708413 chr2:103063369 C/T cg03938978 chr2:103052716 IL18RAP 0.46 5.91 0.31 8.48e-9 Lymphocyte counts; CRC cis rs875971 0.862 rs6460290 chr7:65809106 G/A cg18252515 chr7:66147081 NA 0.4 5.8 0.3 1.57e-8 Aortic root size; CRC cis rs6748734 0.625 rs6741220 chr2:241822432 C/T cg16358738 chr2:241808595 AGXT 0.39 6.86 0.35 3.37e-11 Urinary metabolites; CRC cis rs6912958 0.781 rs9450712 chr6:88193175 C/T cg08069147 chr6:88032118 GJB7;C6orf162 -0.55 -8.24 -0.41 4.03e-15 Monocyte percentage of white cells; CRC cis rs67340775 0.541 rs200975 chr6:27855625 G/T cg03623178 chr6:28175578 NA 0.88 9.15 0.45 6.03e-18 Lung cancer in ever smokers; CRC cis rs2842992 0.830 rs1853259 chr6:160147441 A/G cg11366901 chr6:160182831 ACAT2 -0.93 -12.8 -0.58 9.85e-31 Age-related macular degeneration (geographic atrophy); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg15844609 chr19:38806846 YIF1B 0.43 6.08 0.32 3.24e-9 Response to antipsychotic treatment; CRC cis rs9916302 0.706 rs4488484 chr17:37717377 A/T cg15445000 chr17:37608096 MED1 -0.35 -6.31 -0.33 8.8e-10 Glomerular filtration rate (creatinine); CRC cis rs9372498 0.505 rs4416700 chr6:118975461 G/C cg07617317 chr6:118971624 C6orf204 0.49 5.72 0.3 2.45e-8 Diastolic blood pressure; CRC cis rs12594515 0.967 rs11070465 chr15:45984899 A/G cg06207120 chr15:45996521 NA 0.32 7.77 0.39 1e-13 Waist circumference;Weight; CRC cis rs60871478 0.947 rs4074610 chr7:791755 G/A cg04727924 chr7:799746 HEATR2 -0.44 -6.43 -0.33 4.42e-10 Cerebrospinal P-tau181p levels; CRC cis rs34330 0.562 rs12229100 chr12:12865836 A/G cg04607235 chr12:12878440 APOLD1 0.73 7.56 0.38 3.97e-13 Systemic lupus erythematosus; CRC trans rs3743266 0.613 rs2414669 chr15:60708824 A/G cg23029100 chr15:76603787 ETFA 0.38 5.98 0.31 5.68e-9 Menarche (age at onset); CRC cis rs9487051 0.676 rs6568560 chr6:109592851 G/A cg01475377 chr6:109611718 NA -0.39 -6.89 -0.36 2.77e-11 Reticulocyte fraction of red cells; CRC trans rs10155981 0.510 rs78815495 chr7:22584529 C/T cg10694741 chr17:37382161 STAC2 0.43 6.07 0.32 3.43e-9 Bilirubin levels; CRC trans rs475616 0.917 rs866919 chr10:30513283 C/T cg13852879 chr17:77778467 NA 0.39 5.97 0.31 6.05e-9 Monocyte count; CRC cis rs904251 0.600 rs12211110 chr6:37466232 A/G cg25019722 chr6:37503610 NA -0.38 -6.64 -0.34 1.3e-10 Cognitive performance; CRC cis rs13191362 0.872 rs13194619 chr6:163203657 C/T cg23758597 chr6:163146217 PARK2 -0.68 -6.94 -0.36 2.11e-11 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs6964587 1.000 rs6956431 chr7:91750016 T/C cg17063962 chr7:91808500 NA 0.81 14.33 0.62 1.56e-36 Breast cancer; CRC cis rs853679 0.517 rs9366715 chr6:28064633 A/G cg06470822 chr6:28175283 NA 1.0 13.33 0.59 1.04e-32 Depression; CRC cis rs3617 0.539 rs9880619 chr3:52953055 G/A cg11645453 chr3:52864694 ITIH4 -0.4 -7.84 -0.4 6.26e-14 Red blood cell count;Autism spectrum disorder or schizophrenia; CRC cis rs3751196 0.901 rs77344054 chr12:104161253 C/T cg02344784 chr12:104178138 NT5DC3 0.68 6.76 0.35 6.18e-11 Sense of smell; CRC cis rs9462027 0.628 rs2814969 chr6:34713399 C/A cg07306190 chr6:34760872 UHRF1BP1 -0.35 -6.24 -0.33 1.36e-9 Systemic lupus erythematosus; CRC cis rs1552244 1.000 rs9879080 chr3:10084224 C/T cg02579736 chr3:10068473 FANCD2;CIDECP 0.97 13.13 0.59 6.13e-32 Alzheimer's disease; CRC cis rs7552404 0.696 rs12140121 chr1:76455001 A/G cg10523679 chr1:76189770 ACADM 0.69 8.06 0.41 1.43e-14 Blood metabolite levels;Acylcarnitine levels; CRC cis rs9443645 0.901 rs9361451 chr6:79555055 T/C cg05283184 chr6:79620031 NA -0.57 -9.17 -0.45 5.23e-18 Intelligence (multi-trait analysis); CRC trans rs561341 0.941 rs17780086 chr17:30343282 G/A cg27661571 chr11:113659931 NA -0.96 -11.16 -0.52 9.58e-25 Hip circumference adjusted for BMI; CRC cis rs4481887 0.679 rs4466692 chr1:248423174 C/G cg13385794 chr1:248469461 NA 0.37 6.34 0.33 7.37e-10 Common traits (Other); CRC cis rs13091206 1 rs13091206 chr3:49238718 A/G cg07636037 chr3:49044803 WDR6 0.83 9.09 0.45 9.72e-18 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs6564851 0.506 rs11643509 chr16:81260435 A/C cg05274606 chr16:81253692 PKD1L2 -0.37 -6.12 -0.32 2.61e-9 Carotenoid and tocopherol levels; CRC trans rs2727020 0.556 rs2866365 chr11:49390731 A/G cg03929089 chr4:120376271 NA -0.73 -9.38 -0.46 1.14e-18 Coronary artery disease; CRC cis rs10870270 1.000 rs10430617 chr10:133748889 T/C cg17892150 chr10:133769511 PPP2R2D -0.75 -11.5 -0.54 5.85e-26 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; CRC cis rs881375 0.902 rs2900180 chr9:123706382 T/C cg00246817 chr9:123691163 NA -0.44 -5.75 -0.3 2.06e-8 Rheumatoid arthritis; CRC cis rs7927592 0.956 rs7124078 chr11:68298633 G/T cg01657329 chr11:68192670 LRP5 -0.47 -6.76 -0.35 6.25e-11 Total body bone mineral density; CRC cis rs7264396 0.563 rs2425137 chr20:34345396 G/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.46 -6.51 -0.34 2.83e-10 Total cholesterol levels; CRC cis rs17065868 0.764 rs9525955 chr13:45006463 G/A cg10246903 chr13:45222710 NA 0.56 5.63 0.3 3.82e-8 Antineutrophil cytoplasmic antibody-associated vasculitis; CRC cis rs11098499 0.866 rs12513310 chr4:120288039 T/A cg09307838 chr4:120376055 NA 0.68 10.53 0.5 1.51e-22 Corneal astigmatism; CRC cis rs4660306 0.961 rs4660871 chr1:45995232 C/A cg03123370 chr1:45965343 CCDC163P;MMACHC -0.53 -7.52 -0.38 5.27e-13 Homocysteine levels; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg19729279 chr5:133861951 PHF15 0.4 5.96 0.31 6.48e-9 Intelligence (multi-trait analysis); CRC cis rs2727020 0.521 rs10839299 chr11:49573981 C/T cg25886479 chr11:50257625 LOC441601 -0.34 -5.7 -0.3 2.7e-8 Coronary artery disease; CRC cis rs12580194 0.593 rs61956269 chr12:55768023 C/T cg19537932 chr12:55886519 OR6C68 -0.72 -9.12 -0.45 7.47e-18 Cancer; CRC cis rs765787 0.530 rs12904265 chr15:45526713 C/T cg24006582 chr15:45444508 DUOX1 0.57 8.23 0.41 4.35e-15 Uric acid levels; CRC cis rs929596 0.614 rs10929302 chr2:234665782 G/A cg02227331 chr2:234663937 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 0.41 5.77 0.3 1.84e-8 Total bilirubin levels in HIV-1 infection; CRC cis rs7264396 0.580 rs2064511 chr20:34448810 A/G cg04508476 chr20:34239394 CPNE1;RBM12 0.58 8.59 0.43 3.55e-16 Total cholesterol levels; CRC cis rs9902453 0.904 rs4528633 chr17:28356136 C/T cg26525008 chr17:28256777 EFCAB5;SSH2 -0.7 -11.48 -0.53 7.05e-26 Coffee consumption (cups per day); CRC cis rs17092148 0.652 rs2281695 chr20:33129164 T/C cg08999081 chr20:33150536 PIGU 0.49 6.17 0.32 1.96e-9 Neuroticism; CRC cis rs798554 0.610 rs2644297 chr7:2858906 A/C cg04166393 chr7:2884313 GNA12 0.37 5.68 0.3 3e-8 Height; CRC cis rs2243480 1.000 rs160634 chr7:65528664 C/T cg18252515 chr7:66147081 NA 0.98 12.57 0.57 7.09e-30 Diabetic kidney disease; CRC cis rs7917772 0.503 rs7902306 chr10:104290462 C/T cg22532475 chr10:104410764 TRIM8 -0.36 -6.27 -0.33 1.11e-9 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC cis rs9322193 0.923 rs35961297 chr6:149989065 T/C cg13206674 chr6:150067644 NUP43 0.63 9.32 0.46 1.7e-18 Lung cancer; CRC cis rs9487051 0.872 rs9480922 chr6:109607211 G/A cg01475377 chr6:109611718 NA -0.49 -9.3 -0.46 1.98e-18 Reticulocyte fraction of red cells; CRC cis rs6499255 0.951 rs3169315 chr16:69720964 G/A cg04110750 chr16:69646130 NFAT5 -0.51 -7.42 -0.38 1.03e-12 IgE levels; CRC cis rs847577 0.508 rs12538837 chr7:97684468 C/T cg24562669 chr7:97807699 LMTK2 0.48 7.21 0.37 3.92e-12 Breast cancer; CRC cis rs2652834 1.000 rs11637852 chr15:63397151 G/A cg05507819 chr15:63340323 TPM1 0.47 6.08 0.32 3.41e-9 HDL cholesterol; CRC cis rs1784581 0.855 rs1790002 chr6:162384397 G/T cg17173639 chr6:162384350 PARK2 -0.85 -15.19 -0.64 7.35e-40 Itch intensity from mosquito bite; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg10062258 chr1:65885702 LEPROT;LEPR 0.37 6.05 0.32 3.87e-9 Liver disease severity in Alagille syndrome; CRC cis rs1862618 0.853 rs1833896 chr5:56097669 C/A cg03609598 chr5:56110824 MAP3K1 -0.8 -9.78 -0.47 5.44e-20 Initial pursuit acceleration; CRC cis rs7680126 0.562 rs4698036 chr4:10331294 T/G cg11266682 chr4:10021025 SLC2A9 -0.39 -6.31 -0.33 9.08e-10 Urate levels in lean individuals;Urate levels in overweight individuals;Urate levels in obese individuals; CRC trans rs7615952 0.932 rs11922218 chr3:125631289 C/T cg16558177 chr4:4109446 NA -0.49 -5.99 -0.31 5.37e-9 Blood pressure (smoking interaction); CRC cis rs1670533 0.818 rs585735 chr4:1080391 G/C cg27284194 chr4:1044797 NA 0.49 6.24 0.33 1.37e-9 Recombination rate (females); CRC cis rs7727544 0.735 rs274566 chr5:131715011 A/G cg21138405 chr5:131827807 IRF1 0.32 5.84 0.31 1.28e-8 Blood metabolite levels; CRC cis rs2153535 0.580 rs1034273 chr6:8468145 A/G cg21535247 chr6:8435926 SLC35B3 0.49 7.4 0.38 1.14e-12 Motion sickness; CRC cis rs875971 0.964 rs12668936 chr7:65914404 C/T cg11764359 chr7:65958608 NA 0.61 9.76 0.47 6.36e-20 Aortic root size; CRC cis rs13108904 0.557 rs1250086 chr4:1248051 G/A cg23123621 chr4:1343375 KIAA1530 -0.35 -5.77 -0.3 1.87e-8 Obesity-related traits; CRC cis rs1570884 0.556 rs2146146 chr13:50170368 C/T cg03651054 chr13:50194643 NA 0.34 6.88 0.35 3.01e-11 Sum basophil neutrophil counts;Sum neutrophil eosinophil counts;Neutrophil count;Myeloid white cell count;Granulocyte count; CRC cis rs9311474 0.581 rs4687626 chr3:52569098 G/A cg10802521 chr3:52805072 NEK4 -0.53 -8.37 -0.42 1.71e-15 Electroencephalogram traits; CRC cis rs1799949 1.000 rs4792981 chr17:41308274 A/G cg19454999 chr17:41278357 BRCA1;NBR2 0.55 8.66 0.43 2.2e-16 Menopause (age at onset); CRC cis rs7829975 0.688 rs6601703 chr8:8380224 A/G cg06636001 chr8:8085503 FLJ10661 0.54 8.21 0.41 5.18e-15 Mood instability; CRC trans rs7395662 0.517 rs11039885 chr11:48647107 A/G cg15704280 chr7:45808275 SEPT13 -0.49 -6.99 -0.36 1.58e-11 HDL cholesterol; CRC cis rs7833986 0.534 rs2667980 chr8:56896541 A/T cg23139584 chr8:56987506 RPS20;SNORD54 0.79 11.35 0.53 2e-25 Height; CRC cis rs11148252 0.740 rs7983971 chr13:52790700 C/T cg02158880 chr13:53174818 NA 0.45 6.41 0.33 5.07e-10 Lewy body disease; CRC trans rs1814175 0.616 rs1851848 chr11:49992254 G/C cg15704280 chr7:45808275 SEPT13 -0.95 -16.95 -0.68 9.06e-47 Height; CRC cis rs929596 0.561 rs11891311 chr2:234639310 A/G cg02227331 chr2:234663937 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.41 -6.41 -0.33 5.09e-10 Total bilirubin levels in HIV-1 infection; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg23439141 chr13:113951774 LAMP1 0.46 7.66 0.39 2.07e-13 Liver disease severity in Alagille syndrome; CRC cis rs2115630 1.000 rs11854291 chr15:85363708 T/C cg11189052 chr15:85197271 WDR73 -0.57 -9.45 -0.46 6.56e-19 P wave terminal force; CRC cis rs7584330 0.518 rs13420503 chr2:238437623 G/A cg14458575 chr2:238380390 NA 0.52 6.89 0.36 2.86e-11 Prostate cancer; CRC cis rs1448094 0.511 rs4278581 chr12:86151054 A/G cg02569458 chr12:86230093 RASSF9 -0.48 -8.08 -0.41 1.27e-14 Major depressive disorder; CRC cis rs673253 0.662 rs11586016 chr1:44031793 G/C cg10881128 chr1:44031826 PTPRF 0.23 6.55 0.34 2.18e-10 Intelligence (multi-trait analysis); CRC trans rs561341 0.941 rs736678 chr17:30347423 G/T cg20587970 chr11:113659929 NA -1.37 -19.19 -0.73 1.31e-55 Hip circumference adjusted for BMI; CRC cis rs10045504 0.502 rs72746054 chr5:38762351 C/T cg15396434 chr5:38725168 NA -0.62 -6.08 -0.32 3.31e-9 Night sleep phenotypes; CRC cis rs7043114 0.525 rs6479416 chr9:95053871 G/T cg14631576 chr9:95140430 CENPP -0.3 -5.76 -0.3 1.92e-8 Height; CRC cis rs9916302 0.904 rs8076494 chr17:37516722 A/G cg03013999 chr17:37608204 MED1 -0.46 -6.95 -0.36 1.95e-11 Glomerular filtration rate (creatinine); CRC cis rs9303401 0.659 rs62081316 chr17:56781499 C/T cg02118635 chr17:56770003 RAD51C;TEX14 0.79 10.13 0.49 3.5e-21 Cognitive test performance; CRC cis rs932287 0.540 rs4910442 chr11:9044337 T/C cg00186954 chr11:8933980 ST5;C11orf17 0.38 5.78 0.3 1.75e-8 Colonoscopy-negative controls vs population controls; CRC cis rs2153535 0.580 rs7743418 chr6:8438128 A/C cg07606381 chr6:8435919 SLC35B3 0.67 10.71 0.51 3.8e-23 Motion sickness; CRC cis rs11123170 0.543 rs35222158 chr2:113986629 C/T cg12889195 chr2:113992843 PAX8;LOC440839;LOC654433 0.5 5.91 0.31 8.45e-9 Renal function-related traits (BUN); CRC cis rs1403694 0.695 rs13317089 chr3:186436217 G/C cg04611788 chr3:186434169 KNG1 -0.61 -9.1 -0.45 8.64e-18 Blood protein levels; CRC cis rs2455601 0.638 rs2742485 chr11:8986787 C/G cg09997546 chr11:8931473 C11orf17;ST5 -0.44 -6.14 -0.32 2.42e-9 Schizophrenia; CRC cis rs4713118 0.527 rs9461433 chr6:28095172 C/T cg03623178 chr6:28175578 NA 0.96 12.57 0.57 7.23e-30 Parkinson's disease; CRC trans rs561341 1.000 rs117979353 chr17:30272866 A/G cg20587970 chr11:113659929 NA -1.42 -20.2 -0.74 1.43e-59 Hip circumference adjusted for BMI; CRC cis rs6500602 0.964 rs2304633 chr16:4496973 T/A cg14951292 chr16:4525986 HMOX2;NMRAL1 0.58 8.5 0.42 6.72e-16 Schizophrenia; CRC cis rs449789 0.857 rs1553482 chr6:159722147 T/G cg14500486 chr6:159655392 FNDC1 -0.48 -7.42 -0.38 1.03e-12 Pulse pressure; CRC cis rs1577917 0.771 rs9294337 chr6:86248460 T/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A 0.66 8.73 0.43 1.33e-16 Response to antipsychotic treatment; CRC cis rs6952808 0.609 rs6944877 chr7:1952582 T/G cg22963979 chr7:1858916 MAD1L1 -0.4 -6.38 -0.33 6.13e-10 Bipolar disorder and schizophrenia; CRC cis rs8180040 0.654 rs13078131 chr3:47204939 G/T cg10298567 chr3:47292165 KIF9 -0.37 -6.09 -0.32 3.23e-9 Colorectal cancer; CRC cis rs6460942 0.915 rs62447642 chr7:12489147 T/C cg20607287 chr7:12443886 VWDE -0.67 -6.98 -0.36 1.65e-11 Coronary artery disease; CRC cis rs7666738 0.830 rs34461023 chr4:99023751 C/T cg17366294 chr4:99064904 C4orf37 0.45 7.51 0.38 5.74e-13 Colonoscopy-negative controls vs population controls; CRC cis rs72781680 0.904 rs72796340 chr2:24143622 T/A cg08917208 chr2:24149416 ATAD2B 0.91 9.24 0.45 3.06e-18 Lymphocyte counts; CRC cis rs9914988 0.832 rs4795462 chr17:27130991 C/T cg16670446 chr17:27188758 MIR451;MIR144 0.55 8.52 0.43 5.75e-16 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs4891159 0.548 rs12454625 chr18:74128751 A/G cg24786174 chr18:74118243 ZNF516 0.9 21.07 0.76 5.42e-63 Longevity; CRC cis rs7772486 0.754 rs2328707 chr6:146053498 G/A cg23711669 chr6:146136114 FBXO30 -0.75 -12.8 -0.58 1e-30 Lobe attachment (rater-scored or self-reported); CRC cis rs7412746 0.611 rs10888395 chr1:150762171 C/T cg10589385 chr1:150898437 SETDB1 0.3 6.08 0.32 3.34e-9 Melanoma; CRC cis rs2228479 0.717 rs62052210 chr16:89980158 A/G cg06656553 chr16:89960601 TCF25 -0.56 -5.77 -0.3 1.83e-8 Skin colour saturation; CRC cis rs10229583 0.563 rs10270127 chr7:127262010 G/A cg01233922 chr7:127693937 SND1 -0.44 -6.27 -0.33 1.1e-9 Type 2 diabetes; CRC cis rs938554 0.692 rs13125209 chr4:9982044 A/C cg00071950 chr4:10020882 SLC2A9 0.48 6.73 0.35 7.5e-11 Blood metabolite levels; CRC cis rs9532580 0.553 rs9549250 chr13:41225229 T/G cg21288729 chr13:41239152 FOXO1 0.48 7.48 0.38 6.95e-13 Mean corpuscular hemoglobin; CRC cis rs8141529 0.702 rs469992 chr22:29314899 T/C cg15103426 chr22:29168792 CCDC117 -0.51 -7.17 -0.37 5.1e-12 Lymphocyte counts; CRC cis rs6840360 0.571 rs4696274 chr4:152528478 C/A cg09659197 chr4:152720779 NA 0.32 5.75 0.3 1.99e-8 Intelligence (multi-trait analysis); CRC cis rs2046867 0.818 rs62249860 chr3:72866073 T/G cg25664220 chr3:72788482 NA -0.46 -6.65 -0.34 1.21e-10 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; CRC cis rs6066835 0.867 rs6066844 chr20:47375153 T/C cg18078177 chr20:47281410 PREX1 0.69 5.92 0.31 8.27e-9 Multiple myeloma; CRC cis rs875971 0.545 rs221986 chr7:65570310 T/C cg03233332 chr7:66118400 NA 0.46 6.4 0.33 5.23e-10 Aortic root size; CRC cis rs9916302 0.904 rs9894500 chr17:37515735 G/C cg03013999 chr17:37608204 MED1 -0.46 -6.94 -0.36 2.05e-11 Glomerular filtration rate (creatinine); CRC cis rs2019137 0.901 rs4849176 chr2:113977936 C/T cg21482265 chr2:113992762 PAX8;LOC440839;LOC654433 -0.45 -6.44 -0.33 4.19e-10 Lymphocyte counts; CRC cis rs910316 0.870 rs7147712 chr14:75670707 C/G cg11812906 chr14:75593930 NEK9 -0.52 -7.95 -0.4 3.08e-14 Height; CRC cis rs1005277 0.579 rs2749616 chr10:38510993 A/T cg25517755 chr10:38738941 LOC399744 -0.42 -5.98 -0.31 5.66e-9 Extrinsic epigenetic age acceleration; CRC cis rs11627756 0.957 rs12434778 chr14:103142135 G/T cg12046867 chr14:103022105 NA 0.44 6.03 0.32 4.41e-9 Mean platelet volume; CRC cis rs55665837 1.000 rs11023216 chr11:14437153 G/A cg19336497 chr11:14380999 RRAS2 -0.39 -6.68 -0.35 1.02e-10 Vitamin D levels; CRC cis rs9916302 0.851 rs9904919 chr17:37556431 G/C cg15445000 chr17:37608096 MED1 -0.4 -8.69 -0.43 1.77e-16 Glomerular filtration rate (creatinine); CRC cis rs597539 0.652 rs559032 chr11:68710847 G/T cg06028808 chr11:68637592 NA 0.38 5.96 0.31 6.4e-9 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs73200209 0.912 rs56174185 chr12:116517258 T/C cg01776926 chr12:116560359 MED13L -0.52 -6.25 -0.33 1.24e-9 Total body bone mineral density; CRC cis rs17270561 0.636 rs6923839 chr6:25745853 G/A cg16482183 chr6:26056742 HIST1H1C 0.81 10.22 0.49 1.73e-21 Iron status biomarkers; CRC cis rs2072510 0.569 rs61937881 chr12:96393587 C/T cg22491680 chr12:96389547 HAL -0.5 -6.2 -0.32 1.7e-9 Metabolite levels (small molecules and protein measures); CRC cis rs703842 0.616 rs10877024 chr12:58226709 C/T cg00677455 chr12:58241039 CTDSP2 0.82 11.73 0.54 8.62e-27 Multiple sclerosis; CRC cis rs9354308 0.933 rs1938068 chr6:66607807 T/C cg07460842 chr6:66804631 NA 0.45 5.74 0.3 2.18e-8 Metabolite levels; CRC cis rs1129187 0.686 rs6458313 chr6:42922018 A/G cg26304593 chr6:42947056 PEX6 -0.44 -6.24 -0.33 1.36e-9 Alzheimer's disease in APOE e4+ carriers; CRC cis rs4862750 0.957 rs2375916 chr4:187903923 A/G cg07414643 chr4:187882934 NA 0.35 5.75 0.3 2e-8 Lobe attachment (rater-scored or self-reported); CRC cis rs4862750 0.914 rs6837117 chr4:187872379 C/T cg07414643 chr4:187882934 NA 0.37 6.47 0.34 3.47e-10 Lobe attachment (rater-scored or self-reported); CRC cis rs3818285 0.515 rs4918471 chr10:111660500 C/A cg00817464 chr10:111662876 XPNPEP1 -0.47 -6.45 -0.34 3.88e-10 Superior crus of antihelix expression; CRC cis rs2227564 0.729 rs2688617 chr10:75646147 A/T cg00564723 chr10:75632066 CAMK2G -0.34 -7.84 -0.4 6.22e-14 Crohn's disease;Inflammatory bowel disease; CRC trans rs10982213 0.830 rs2274163 chr9:117188714 C/T cg00012762 chr17:72744649 SLC9A3R1 0.43 6.97 0.36 1.72e-11 Interleukin-6 levels; CRC cis rs2354432 0.607 rs68080346 chr1:146708484 T/C cg25205988 chr1:146714368 CHD1L -1.11 -9.49 -0.46 4.7e-19 Mitochondrial DNA levels; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg27507545 chr10:103880405 LDB1 0.45 6.05 0.32 3.83e-9 Thyroid stimulating hormone; CRC cis rs344364 0.629 rs9806826 chr16:1894912 C/T cg09830162 chr16:1889614 FAHD1;C16orf73 -0.58 -8.61 -0.43 3e-16 Glomerular filtration rate in chronic kidney disease; CRC cis rs7618915 0.547 rs2286800 chr3:52778051 C/T cg08222913 chr3:52553049 STAB1 -0.33 -6.02 -0.31 4.78e-9 Bipolar disorder; CRC cis rs4731207 0.596 rs10280341 chr7:124583935 A/G cg23710748 chr7:124431027 NA -0.38 -6.08 -0.32 3.25e-9 Cutaneous malignant melanoma; CRC trans rs916888 0.779 rs199498 chr17:44865603 A/G cg22433210 chr17:43662623 NA 0.73 8.22 0.41 4.85e-15 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs11098499 0.863 rs1155576 chr4:120450159 A/C cg09307838 chr4:120376055 NA 0.69 10.39 0.5 4.7e-22 Corneal astigmatism; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg11254426 chr10:127464165 MMP21 -0.4 -6.74 -0.35 7.06e-11 Liver disease severity in Alagille syndrome; CRC cis rs2836974 0.897 rs34394827 chr21:40528087 T/C cg06238570 chr21:40685208 BRWD1 0.74 10.37 0.5 5.5e-22 Cognitive function; CRC cis rs2153535 0.601 rs6906170 chr6:8543128 T/A cg21535247 chr6:8435926 SLC35B3 0.5 7.78 0.39 9.25e-14 Motion sickness; CRC trans rs12940923 1.000 rs34861306 chr17:56377187 G/A cg16900910 chr15:72789182 ARIH1 0.53 6.08 0.32 3.35e-9 Circulating myeloperoxidase levels (plasma); CRC cis rs2013441 1.000 rs2703810 chr17:20113715 C/T cg13482628 chr17:19912719 NA -0.42 -6.57 -0.34 1.95e-10 Obesity-related traits; CRC cis rs7640424 0.819 rs34937412 chr3:107829484 G/C cg09227934 chr3:107805635 CD47 -0.46 -6.7 -0.35 9.1e-11 Body mass index; CRC cis rs7811142 1.000 rs67239991 chr7:100046504 A/G cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.76 10.89 0.51 8.98e-24 Platelet count; CRC cis rs4319547 0.956 rs10847179 chr12:123040985 T/C cg05707623 chr12:122985044 ZCCHC8 -0.8 -9.97 -0.48 1.28e-20 Body mass index; CRC cis rs6951245 1.000 rs11763020 chr7:1060288 C/T cg03188948 chr7:1209495 NA 0.58 6.01 0.31 4.98e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs7772486 0.790 rs9791313 chr6:146266172 T/C cg23711669 chr6:146136114 FBXO30 -0.65 -11.14 -0.52 1.1e-24 Lobe attachment (rater-scored or self-reported); CRC cis rs561341 0.714 rs55925849 chr17:30253085 C/T cg12193833 chr17:30244370 NA -0.73 -8.5 -0.42 6.48e-16 Hip circumference adjusted for BMI; CRC cis rs2742417 1.000 rs2673033 chr3:45756350 C/G cg04837898 chr3:45731254 SACM1L -0.36 -5.88 -0.31 1.01e-8 Response to anti-depressant treatment in major depressive disorder; CRC trans rs10504229 1.000 rs58371676 chr8:58189382 G/A cg04077850 chr5:125800366 GRAMD3 0.37 6.27 0.33 1.15e-9 Developmental language disorder (linguistic errors); CRC cis rs672059 1.000 rs652753 chr1:183156569 A/T ch.1.3577855R chr1:183094577 LAMC1 0.49 7.13 0.37 6.54e-12 Hypertriglyceridemia; CRC cis rs7945705 0.747 rs1980429 chr11:9010474 C/A cg14711859 chr11:8959438 ASCL3 0.38 6.35 0.33 7.19e-10 Hemoglobin concentration; CRC trans rs11098499 0.562 rs58583086 chr4:120556362 A/G cg25214090 chr10:38739885 LOC399744 -0.51 -8.22 -0.41 4.7e-15 Corneal astigmatism; CRC cis rs7647973 1.000 rs62261249 chr3:49594060 T/C cg20833759 chr3:49053208 WDR6;DALRD3 -0.61 -8.69 -0.43 1.73e-16 Menarche (age at onset); CRC cis rs853679 0.517 rs12174753 chr6:28042465 C/G cg15786705 chr6:28176104 NA 0.73 9.26 0.45 2.63e-18 Depression; CRC cis rs35306767 0.855 rs34251037 chr10:867884 C/T cg26597838 chr10:835615 NA 1.25 15.13 0.64 1.26e-39 Eosinophil percentage of granulocytes; CRC cis rs3741404 0.672 rs4980524 chr11:63959259 A/C cg19465662 chr11:63993652 NUDT22;TRPT1 0.75 12.1 0.55 4e-28 Platelet count; CRC cis rs801193 1.000 rs2659909 chr7:66160279 G/A cg00343986 chr7:65444356 GUSB 0.46 6.81 0.35 4.59e-11 Aortic root size; CRC cis rs7680126 0.530 rs2903827 chr4:10175872 C/G cg00071950 chr4:10020882 SLC2A9 -0.46 -6.04 -0.32 4.27e-9 Urate levels in lean individuals;Urate levels in overweight individuals;Urate levels in obese individuals; CRC cis rs11098499 0.863 rs3775854 chr4:120471971 C/T cg09307838 chr4:120376055 NA 0.67 10.09 0.49 4.88e-21 Corneal astigmatism; CRC cis rs7224685 0.520 rs12453690 chr17:4037678 T/C cg11204139 chr17:3907470 NA -0.73 -12.92 -0.58 3.48e-31 Type 2 diabetes; CRC cis rs7811142 0.779 rs77370288 chr7:99947897 A/T cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.74 9.89 0.48 2.36e-20 Platelet count; CRC cis rs12681287 0.547 rs13260345 chr8:87483721 T/C cg27223183 chr8:87520930 FAM82B -0.53 -7.52 -0.38 5.31e-13 Caudate activity during reward; CRC cis rs6545883 0.524 rs17482440 chr2:61548857 C/T cg10580144 chr2:61372316 C2orf74 -0.35 -7.93 -0.4 3.4e-14 Tuberculosis; CRC cis rs9303280 0.743 rs12946510 chr17:37912377 C/T cg11212589 chr17:38028394 ZPBP2 0.34 5.9 0.31 9.02e-9 Self-reported allergy; CRC cis rs2735413 0.881 rs12920025 chr16:78083005 C/T cg04733911 chr16:78082701 NA -0.45 -7.41 -0.38 1.11e-12 Systolic blood pressure (alcohol consumption interaction); CRC cis rs10489202 0.608 rs10918827 chr1:168077044 A/G cg24449463 chr1:168025552 DCAF6 0.51 7.29 0.37 2.26e-12 Schizophrenia; CRC cis rs2072510 0.569 rs7970524 chr12:96390152 A/G cg15438951 chr12:96389694 HAL -0.46 -5.88 -0.31 9.93e-9 Metabolite levels (small molecules and protein measures); CRC trans rs11098499 0.564 rs11098507 chr4:120288286 G/A cg25214090 chr10:38739885 LOC399744 0.61 9.66 0.47 1.39e-19 Corneal astigmatism; CRC trans rs9585327 0.584 rs4772260 chr13:100645723 A/G cg13237843 chr11:6640720 TPP1 0.42 6.75 0.35 6.58e-11 Myopia; CRC cis rs4332037 0.950 rs62442895 chr7:1936938 G/A cg23378565 chr7:2036160 MAD1L1 -0.46 -6.51 -0.34 2.85e-10 Bipolar disorder; CRC cis rs6662572 0.671 rs10749861 chr1:46440252 A/C cg03123370 chr1:45965343 CCDC163P;MMACHC -0.44 -5.7 -0.3 2.71e-8 Blood protein levels; CRC cis rs1008375 1.000 rs6854733 chr4:17640526 C/T cg04450456 chr4:17643702 FAM184B 0.41 6.72 0.35 8.23e-11 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs3771570 0.901 rs4675963 chr2:242324763 G/A cg21155796 chr2:242212141 HDLBP 0.55 6.67 0.34 1.12e-10 Prostate cancer; CRC cis rs13191362 0.935 rs73008456 chr6:163013697 G/A cg23758597 chr6:163146217 PARK2 -0.55 -6.12 -0.32 2.7e-9 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs8044868 0.512 rs10048144 chr16:72052891 C/G cg06172871 chr16:72088244 HP 0.44 6.35 0.33 7.31e-10 Body mass index (change over time) in cancer or chronic obstructive pulmonary disease;Body mass index (change over time) in cancer; CRC cis rs7917772 0.560 rs729023 chr10:104341887 A/G cg11453585 chr10:104263688 ACTR1A;SUFU -0.83 -15.19 -0.64 7.35e-40 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC cis rs8180040 0.726 rs1869869 chr3:47027833 G/A cg27129171 chr3:47204927 SETD2 0.66 10.35 0.5 6.25e-22 Colorectal cancer; CRC cis rs7945705 0.967 rs2568090 chr11:8849495 T/C cg12365402 chr11:9010492 NRIP3 0.39 6.16 0.32 2.07e-9 Hemoglobin concentration; CRC cis rs13191362 0.935 rs13219926 chr6:163004213 T/C cg21926612 chr6:163149169 PACRG;PARK2 0.8 11.15 0.52 1.08e-24 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs642858 1.000 rs1361248 chr6:140295358 A/G cg27524944 chr6:140295369 NA -0.37 -6.15 -0.32 2.24e-9 Type 2 diabetes; CRC cis rs12024301 0.557 rs77047385 chr1:183643180 C/T cg11505048 chr1:183622726 RGL1;APOBEC4 0.81 7.06 0.36 1.01e-11 Peripheral arterial disease (traffic-related air pollution interaction); CRC trans rs7647973 0.710 rs6446284 chr3:49616997 A/G cg21665057 chr3:196295764 WDR53;FBXO45 -0.67 -6.94 -0.36 2.13e-11 Menarche (age at onset); CRC trans rs2228479 0.850 rs62054599 chr16:89808850 C/G cg21302420 chr1:112162376 RAP1A 0.72 5.96 0.31 6.38e-9 Skin colour saturation; CRC cis rs2404602 0.692 rs59088060 chr15:76859974 T/C cg22467129 chr15:76604101 ETFA -0.39 -6.43 -0.33 4.59e-10 Blood metabolite levels; CRC cis rs72615157 0.595 rs112241539 chr7:99847237 C/T cg07160278 chr7:100027354 MEPCE;ZCWPW1 0.77 8.75 0.43 1.16e-16 Lung function (FEV1/FVC); CRC cis rs28386778 0.830 rs2597637 chr17:61875066 T/G cg22520471 chr17:61851767 DDX42;CCDC47 0.75 11.65 0.54 1.65e-26 Prudent dietary pattern; CRC cis rs9522267 0.511 rs1163626 chr13:112225200 A/C cg10483660 chr13:112241077 NA -0.48 -9.11 -0.45 7.99e-18 Hepatitis; CRC cis rs873946 0.564 rs12772704 chr10:134557318 G/A cg18305652 chr10:134549665 INPP5A 0.48 6.12 0.32 2.73e-9 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CRC cis rs1153858 1.000 rs10519021 chr15:45631795 G/A cg14582100 chr15:45693742 SPATA5L1 0.28 5.81 0.31 1.45e-8 Homoarginine levels; CRC trans rs747782 0.528 rs11039674 chr11:48336116 C/T cg03929089 chr4:120376271 NA 0.67 6.42 0.33 4.68e-10 Intraocular pressure; CRC cis rs798554 0.704 rs798512 chr7:2782592 C/G cg19717773 chr7:2847554 GNA12 -0.41 -6.71 -0.35 8.3e-11 Height; CRC cis rs853679 0.517 rs17774663 chr6:28120898 G/A cg02683197 chr6:28174875 NA 0.87 10.73 0.51 3.25e-23 Depression; CRC cis rs7772486 0.790 rs9485024 chr6:146142487 A/G cg23711669 chr6:146136114 FBXO30 -0.64 -10.8 -0.51 1.72e-23 Lobe attachment (rater-scored or self-reported); CRC cis rs6032067 0.929 rs17424578 chr20:43806321 A/G cg10761708 chr20:43804764 PI3 0.51 5.86 0.31 1.15e-8 Blood protein levels; CRC cis rs1018836 0.892 rs11776824 chr8:91553256 T/C cg16814680 chr8:91681699 NA -0.64 -10.3 -0.49 9.3e-22 Ejection fraction in Tripanosoma cruzi seropositivity; CRC cis rs7208859 0.573 rs11654035 chr17:29136426 T/C cg13385521 chr17:29058706 SUZ12P 0.74 8.25 0.41 3.81e-15 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs34638657 0.518 rs2288050 chr16:82183403 C/T cg07918374 chr16:82182319 MPHOSPH6 -0.41 -5.8 -0.3 1.52e-8 Lung adenocarcinoma; CRC cis rs7107770 0.739 rs12808899 chr11:125082124 T/C cg27629782 chr11:125073726 PKNOX2 0.53 7.75 0.39 1.16e-13 Photic sneeze reflex; CRC cis rs992157 0.835 rs6729058 chr2:219148369 G/A cg13835894 chr2:219148914 PNKD;TMBIM1 -0.36 -6.81 -0.35 4.74e-11 Colorectal cancer; CRC cis rs1887596 0.705 rs4771004 chr13:27214082 A/G cg01312412 chr13:27282625 NA 0.43 5.9 0.31 8.84e-9 Facial morphology (factor 3, length of philtrum); CRC cis rs6142102 0.961 rs6119447 chr20:32668576 A/G cg08999081 chr20:33150536 PIGU 0.37 5.79 0.3 1.63e-8 Skin pigmentation; CRC cis rs6964587 1.000 rs60147309 chr7:91736098 C/G cg17063962 chr7:91808500 NA 0.8 13.89 0.61 7.52e-35 Breast cancer; CRC cis rs6952808 0.723 rs60995052 chr7:2030007 G/C cg22963979 chr7:1858916 MAD1L1 -0.53 -7.7 -0.39 1.66e-13 Bipolar disorder and schizophrenia; CRC trans rs57221529 0.766 rs17563576 chr5:560476 A/G cg11887960 chr12:57824829 NA 0.55 6.33 0.33 7.86e-10 Lung disease severity in cystic fibrosis; CRC cis rs7617773 0.817 rs9834095 chr3:48327751 G/A cg11946769 chr3:48343235 NME6 0.64 8.85 0.44 5.61e-17 Coronary artery disease; CRC trans rs3942852 0.688 rs10742834 chr11:48169717 G/A cg03929089 chr4:120376271 NA -0.72 -9.05 -0.45 1.27e-17 Acute lymphoblastic leukemia (childhood); CRC cis rs875971 0.862 rs13536 chr7:66019190 G/A cg00343986 chr7:65444356 GUSB -0.44 -6.15 -0.32 2.21e-9 Aortic root size; CRC cis rs4285028 0.747 rs11928871 chr3:121483388 G/C cg11130432 chr3:121712080 ILDR1 -0.54 -6.28 -0.33 1.04e-9 Multiple sclerosis; CRC cis rs916888 0.779 rs199498 chr17:44865603 A/G cg01570182 chr17:44337453 NA 0.93 11.07 0.52 1.98e-24 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs2404602 1.000 rs12443137 chr15:76840832 G/T cg23625390 chr15:77176239 SCAPER 0.59 9.21 0.45 4.06e-18 Blood metabolite levels; CRC cis rs3204270 0.639 rs62080199 chr17:79627906 T/G cg09655341 chr17:79618100 PDE6G 0.63 7.21 0.37 3.83e-12 Dental caries; CRC cis rs17376456 0.877 rs34184666 chr5:93444584 T/C cg25358565 chr5:93447407 FAM172A 1.02 10.47 0.5 2.42e-22 Diabetic retinopathy; CRC cis rs11212617 1.000 rs654005 chr11:108155397 G/A cg14761454 chr11:108092087 ATM;NPAT 0.42 6.26 0.33 1.2e-9 Response to metformin in type 2 diabetes (glycemic); CRC cis rs4474465 0.850 rs7117513 chr11:78206418 T/G cg27205649 chr11:78285834 NARS2 0.47 5.79 0.3 1.61e-8 Alzheimer's disease (survival time); CRC cis rs58688157 0.705 rs12800061 chr11:587425 C/A cg09218773 chr11:619014 MUPCDH -0.42 -5.95 -0.31 6.95e-9 Systemic lupus erythematosus; CRC cis rs4332037 0.539 rs868754 chr7:2033780 G/C cg23378565 chr7:2036160 MAD1L1 -0.51 -6.87 -0.35 3.21e-11 Bipolar disorder; CRC trans rs66887589 0.807 rs7694483 chr4:120405929 T/A cg25214090 chr10:38739885 LOC399744 0.4 6.33 0.33 8.21e-10 Diastolic blood pressure; CRC cis rs780096 0.526 rs3845687 chr2:27689899 T/C cg17158414 chr2:27665306 KRTCAP3 -0.28 -6.09 -0.32 3.06e-9 Total body bone mineral density; CRC cis rs1448094 0.967 rs1374995 chr12:86341764 A/G cg02569458 chr12:86230093 RASSF9 0.4 6.85 0.35 3.7e-11 Major depressive disorder; CRC cis rs12410462 0.681 rs115956039 chr1:227661978 G/A cg23173402 chr1:227635558 NA 0.85 8.65 0.43 2.36e-16 Major depressive disorder; CRC cis rs7208859 0.623 rs8067035 chr17:29102188 T/C cg01831904 chr17:28903510 LRRC37B2 -0.63 -6.62 -0.34 1.47e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs10504229 0.683 rs7827014 chr8:58132230 G/A cg02725872 chr8:58115012 NA -0.64 -11.55 -0.54 3.85e-26 Developmental language disorder (linguistic errors); CRC cis rs17376456 0.825 rs13171131 chr5:93223028 C/T cg09848695 chr5:92956644 FAM172A;MIR2277 0.67 6.02 0.32 4.63e-9 Diabetic retinopathy; CRC cis rs2797160 1.000 rs983543 chr6:126005767 G/A cg05901451 chr6:126070800 HEY2 -0.4 -6.18 -0.32 1.93e-9 Endometrial cancer; CRC cis rs769267 0.929 rs2905421 chr19:19457908 G/T cg20644253 chr19:19431407 KIAA0892;SF4 0.42 5.76 0.3 1.96e-8 Tonsillectomy; CRC cis rs727505 0.866 rs66650870 chr7:124713194 T/C cg23710748 chr7:124431027 NA -0.73 -12.7 -0.57 2.47e-30 Lewy body disease; CRC cis rs1865760 0.892 rs9379806 chr6:25940958 G/A cg17691542 chr6:26056736 HIST1H1C 0.54 7.73 0.39 1.35e-13 Height; CRC trans rs561341 0.943 rs508566 chr17:30289861 G/C cg27661571 chr11:113659931 NA -0.96 -11.22 -0.53 5.78e-25 Hip circumference adjusted for BMI; CRC cis rs6545883 0.894 rs12620105 chr2:61512321 A/T cg15711740 chr2:61764176 XPO1 0.43 5.72 0.3 2.36e-8 Tuberculosis; CRC cis rs939584 1.000 rs2867114 chr2:651380 C/T cg03610516 chr2:642275 NA -0.43 -5.94 -0.31 7.33e-9 Body mass index; CRC cis rs28386778 0.897 rs9912557 chr17:61784963 C/A cg06601766 chr17:61851465 DDX42;CCDC47 0.45 6.05 0.32 3.88e-9 Prudent dietary pattern; CRC cis rs13191362 0.810 rs13200053 chr6:163011443 G/A cg06582575 chr6:163149167 PACRG;PARK2 0.75 10.24 0.49 1.58e-21 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs12451471 0.559 rs34746710 chr17:78079224 G/A cg24585782 chr17:78113791 EIF4A3 -0.52 -7.32 -0.37 1.97e-12 Plateletcrit;Mean corpuscular hemoglobin concentration; CRC cis rs2066819 1.000 rs75598973 chr12:56746558 C/T cg26714650 chr12:56694279 CS -1.44 -11.18 -0.52 8.02e-25 Psoriasis vulgaris; CRC cis rs7113874 0.524 rs9300090 chr11:8585384 G/A cg20771178 chr11:8615675 STK33 -0.36 -5.65 -0.3 3.5e-8 Body mass index in physically active individuals;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs2153535 0.580 rs9406171 chr6:8515362 T/C cg07606381 chr6:8435919 SLC35B3 0.66 10.72 0.51 3.48e-23 Motion sickness; CRC cis rs514406 0.644 rs7530078 chr1:53204861 G/T cg27535305 chr1:53392650 SCP2 0.34 6.36 0.33 6.57e-10 Monocyte count; CRC cis rs4665809 0.590 rs72809668 chr2:26467653 C/T cg26119090 chr2:26468346 HADHA;HADHB 1.06 15.5 0.65 4.69e-41 Gut microbiome composition (summer); CRC cis rs1218582 0.741 rs11264291 chr1:154914797 C/T cg09359103 chr1:154839909 KCNN3 -0.72 -12.45 -0.57 1.99e-29 Prostate cancer; CRC cis rs9467711 0.591 rs35902160 chr6:26128538 C/G cg08501292 chr6:25962987 TRIM38 0.64 6.15 0.32 2.27e-9 Autism spectrum disorder or schizophrenia; CRC trans rs7939886 0.920 rs79521305 chr11:55811332 G/A cg03929089 chr4:120376271 NA 0.66 5.98 0.31 5.9e-9 Myopia (pathological); CRC cis rs6460942 0.591 rs4721079 chr7:12337742 A/G cg06484146 chr7:12443880 VWDE -0.6 -6.59 -0.34 1.75e-10 Coronary artery disease; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg02349096 chr19:11450198 RAB3D 0.38 6.03 0.32 4.43e-9 Liver disease severity in Alagille syndrome; CRC cis rs1862618 0.802 rs4389648 chr5:56103602 A/G cg22800045 chr5:56110881 MAP3K1 0.57 6.19 0.32 1.83e-9 Initial pursuit acceleration; CRC trans rs208520 0.690 rs10944872 chr6:66708239 T/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.96 13.68 0.6 4.84e-34 Exhaled nitric oxide output; CRC cis rs72615157 0.561 rs113401658 chr7:99858505 C/T cg07160278 chr7:100027354 MEPCE;ZCWPW1 0.78 8.98 0.44 2.12e-17 Lung function (FEV1/FVC); CRC cis rs921968 0.565 rs2272191 chr2:219609776 G/A cg02176678 chr2:219576539 TTLL4 -0.39 -6.23 -0.32 1.4e-9 Mean corpuscular hemoglobin concentration; CRC cis rs6662572 0.737 rs4256763 chr1:46379518 A/G cg08644498 chr1:46502608 NA -0.44 -6.85 -0.35 3.69e-11 Blood protein levels; CRC cis rs2439831 0.850 rs28858500 chr15:44156942 C/T cg02155558 chr15:43621948 ADAL;LCMT2 0.68 7.44 0.38 8.68e-13 Lung cancer in ever smokers; CRC cis rs4665809 1.000 rs4665823 chr2:26312723 A/G cg26119090 chr2:26468346 HADHA;HADHB -0.62 -7.95 -0.4 2.95e-14 Gut microbiome composition (summer); CRC cis rs875971 0.862 rs801204 chr7:66022921 T/C cg11764359 chr7:65958608 NA -0.59 -8.82 -0.44 6.62e-17 Aortic root size; CRC cis rs2228479 0.850 rs11076623 chr16:89844120 G/T cg06656553 chr16:89960601 TCF25 -0.71 -5.96 -0.31 6.42e-9 Skin colour saturation; CRC cis rs1559088 0.948 rs7257858 chr19:33591231 T/C cg27124370 chr19:33622961 WDR88 0.45 6.3 0.33 9.74e-10 Bone ultrasound measurement (broadband ultrasound attenuation); CRC cis rs9322193 0.962 rs9688412 chr6:150124283 A/G cg07701084 chr6:150067640 NUP43 -0.46 -6.58 -0.34 1.84e-10 Lung cancer; CRC cis rs834811 0.871 rs834819 chr7:135895281 G/A cg01726295 chr7:135938950 NA 0.4 6.92 0.36 2.31e-11 Post-traumatic stress disorder; CRC cis rs782590 0.967 rs6545506 chr2:55798108 A/G cg18811423 chr2:55921094 PNPT1 -0.78 -14.41 -0.62 7.82e-37 Metabolic syndrome; CRC cis rs6088590 0.582 rs6059909 chr20:33139691 C/A cg24642439 chr20:33292090 TP53INP2 0.41 7.01 0.36 1.35e-11 Coronary artery disease; CRC cis rs270601 0.770 rs4361510 chr5:131599647 C/T cg24060327 chr5:131705240 SLC22A5 -0.4 -6.21 -0.32 1.59e-9 Acylcarnitine levels; CRC cis rs4919694 1.000 rs10509758 chr10:104681710 T/C cg04362960 chr10:104952993 NT5C2 1.06 9.98 0.48 1.11e-20 Arsenic metabolism; CRC cis rs7224737 1.000 rs11869069 chr17:40287101 C/G cg02450064 chr17:40260053 DHX58 -0.43 -6.21 -0.32 1.64e-9 Fibrinogen levels; CRC cis rs7107174 1.000 rs2511182 chr11:77982130 G/C cg02023728 chr11:77925099 USP35 0.51 7.36 0.38 1.51e-12 Testicular germ cell tumor; CRC cis rs10256972 0.616 rs4585652 chr7:1145396 A/G cg04025307 chr7:1156635 C7orf50 0.73 11.69 0.54 1.19e-26 Longevity;Endometriosis; CRC cis rs7781266 0.501 rs28551473 chr7:133631089 G/C cg03336402 chr7:133662267 EXOC4 0.67 10.32 0.49 8.37e-22 Educational attainment (college completion); CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg08483723 chr3:45267960 TMEM158 -0.33 -6.02 -0.31 4.58e-9 Myopia (pathological); CRC trans rs58106596 0.660 rs62197212 chr2:232562727 G/A cg01370599 chr3:116745421 NA 0.88 10.4 0.5 4.42e-22 White blood cell count;Lymphocyte counts; CRC cis rs11148252 0.574 rs2038826 chr13:53280013 G/A cg12458913 chr13:53173898 NA 0.76 13.79 0.61 1.8e-34 Lewy body disease; CRC cis rs12477438 0.501 rs13008171 chr2:99743419 G/A cg26064155 chr2:99771622 LIPT1;TSGA10 0.77 12.95 0.58 2.85e-31 Chronic sinus infection; CRC cis rs1005277 0.579 rs2474588 chr10:38420870 A/G cg25427524 chr10:38739819 LOC399744 -0.75 -13.3 -0.59 1.39e-32 Extrinsic epigenetic age acceleration; CRC trans rs8002861 0.664 rs9567292 chr13:44444816 A/G cg17145862 chr1:211918768 LPGAT1 0.57 9.83 0.48 3.72e-20 Leprosy; CRC cis rs7940866 0.834 rs10894302 chr11:130861994 C/T cg12179176 chr11:130786555 SNX19 0.6 8.52 0.43 5.7e-16 Schizophrenia; CRC cis rs7246657 0.943 rs10415937 chr19:37830064 T/G cg23950597 chr19:37808831 NA -0.47 -5.77 -0.3 1.86e-8 Coronary artery calcification; CRC cis rs8031584 0.958 rs61997079 chr15:31238271 G/C cg14829155 chr15:31115871 NA -0.5 -8.12 -0.41 9.41e-15 Huntington's disease progression; CRC cis rs4481887 0.745 rs4540687 chr1:248476099 C/G cg13385794 chr1:248469461 NA 0.38 6.65 0.34 1.26e-10 Common traits (Other); CRC cis rs6951245 1.000 rs78523927 chr7:1089458 T/C cg20603222 chr7:1096387 C7orf50;GPR146 -0.73 -8.49 -0.42 7.07e-16 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs13118159 0.836 rs2276903 chr4:1343405 A/G cg15763984 chr4:1342303 KIAA1530 0.49 8.72 0.43 1.38e-16 Longevity; CRC cis rs11098499 0.505 rs75122014 chr4:120362426 G/C cg09307838 chr4:120376055 NA 0.72 11.14 0.52 1.1e-24 Corneal astigmatism; CRC cis rs611744 0.647 rs615233 chr8:109254262 C/T cg21045802 chr8:109455806 TTC35 0.42 6.65 0.34 1.24e-10 Dupuytren's disease; CRC cis rs9611565 0.512 rs9607841 chr22:42186838 G/A cg06481639 chr22:41940642 POLR3H -0.6 -6.74 -0.35 7.08e-11 Vitiligo; CRC cis rs4363385 0.747 rs1415971 chr1:152965779 T/G cg25856811 chr1:152973957 SPRR3 -0.26 -7.27 -0.37 2.72e-12 Inflammatory skin disease; CRC cis rs769267 1.000 rs769267 chr19:19446936 A/G cg20644253 chr19:19431407 KIAA0892;SF4 0.41 5.72 0.3 2.44e-8 Tonsillectomy; CRC cis rs2495707 0.624 rs2489007 chr10:102422046 A/G cg03932441 chr10:102415297 NA 0.33 5.75 0.3 2.06e-8 Body mass index; CRC cis rs9322193 0.961 rs9285521 chr6:149906712 T/G cg13206674 chr6:150067644 NUP43 0.67 9.8 0.48 4.66e-20 Lung cancer; CRC cis rs7666738 0.830 rs991169 chr4:98928567 C/A cg05340658 chr4:99064831 C4orf37 0.6 9.35 0.46 1.41e-18 Colonoscopy-negative controls vs population controls; CRC cis rs9660180 0.620 rs3817856 chr1:1663831 C/T cg23982607 chr1:1823379 GNB1 0.42 5.87 0.31 1.08e-8 Body mass index; CRC cis rs6582630 0.537 rs66855609 chr12:38299029 T/C cg26384229 chr12:38710491 ALG10B 0.67 9.94 0.48 1.61e-20 Drug-induced liver injury (flucloxacillin); CRC cis rs796364 0.951 rs6722092 chr2:201059371 G/T cg25936922 chr2:200820526 C2orf60;C2orf47 0.53 5.88 0.31 1.01e-8 Schizophrenia; CRC cis rs394563 0.559 rs13219868 chr6:149686518 T/G cg16235748 chr6:149772707 ZC3H12D 0.37 6.8 0.35 4.97e-11 Dupuytren's disease; CRC cis rs6952808 0.729 rs35797753 chr7:1954914 G/A cg02951883 chr7:2050386 MAD1L1 -0.68 -10.72 -0.51 3.44e-23 Bipolar disorder and schizophrenia; CRC cis rs473651 0.935 rs483166 chr2:239346641 C/T cg08773314 chr2:239334832 ASB1 -0.38 -8.57 -0.43 4.03e-16 Multiple system atrophy; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg01139526 chr5:139682850 PFDN1 0.47 6.76 0.35 6.47e-11 Intelligence (multi-trait analysis); CRC cis rs4820539 1.000 rs5759595 chr22:23471624 G/A cg14186256 chr22:23484241 RTDR1 0.92 18.32 0.71 3.46e-52 Bone mineral density; CRC cis rs7552404 0.883 rs77773255 chr1:76217193 G/A cg03433033 chr1:76189801 ACADM 0.82 11.25 0.53 4.73e-25 Blood metabolite levels;Acylcarnitine levels; CRC cis rs478304 0.934 rs1193692 chr11:65504069 A/C cg08755490 chr11:65554678 OVOL1 0.43 6.39 0.33 5.53e-10 Acne (severe); CRC cis rs6684514 0.845 rs12138564 chr1:156291600 G/T cg16558208 chr1:156270281 VHLL 0.56 8.78 0.44 9.09e-17 Mean corpuscular hemoglobin concentration;Glycated hemoglobin levels; CRC cis rs55788414 0.932 rs9940095 chr16:81182108 A/G cg06400318 chr16:81190750 PKD1L2 -0.59 -6.78 -0.35 5.73e-11 Left ventricular obstructive tract defect (maternal effect); CRC cis rs7909074 0.831 rs11239271 chr10:45376294 A/G cg04218760 chr10:45406644 TMEM72 -0.33 -9.54 -0.47 3.34e-19 Mean corpuscular volume; CRC cis rs9902453 0.934 rs12453172 chr17:28441590 G/C cg26525008 chr17:28256777 EFCAB5;SSH2 0.58 8.72 0.43 1.44e-16 Coffee consumption (cups per day); CRC cis rs10905065 0.965 rs10795520 chr10:5764160 G/A cg11519256 chr10:5708881 ASB13 0.48 7.12 0.37 7e-12 Menopause (age at onset); CRC cis rs6500395 1.000 rs34844432 chr16:48682418 C/T cg04672837 chr16:48644449 N4BP1 0.45 6.63 0.34 1.38e-10 Response to tocilizumab in rheumatoid arthritis; CRC cis rs10256972 0.552 rs6978842 chr7:1204599 A/C cg18765753 chr7:1198926 ZFAND2A -0.52 -9.65 -0.47 1.48e-19 Longevity;Endometriosis; CRC cis rs10751667 0.621 rs7396107 chr11:970029 C/T cg06064525 chr11:970664 AP2A2 -0.3 -6.11 -0.32 2.78e-9 Alzheimer's disease (late onset); CRC cis rs1552244 1.000 rs7615646 chr3:10089773 A/C cg08888203 chr3:10149979 C3orf24 0.73 10.16 0.49 2.86e-21 Alzheimer's disease; CRC cis rs6429082 0.634 rs3856245 chr1:235571428 G/A cg26050004 chr1:235667680 B3GALNT2 -0.44 -5.83 -0.31 1.33e-8 Adiposity; CRC cis rs2786111 0.928 rs554009 chr1:197294699 C/T cg13682187 chr1:196946512 CFHR5 0.29 5.74 0.3 2.17e-8 Lupus nephritis in systemic lupus erythematosus; CRC cis rs7937682 0.889 rs493865 chr11:111495178 A/C cg19812747 chr11:111475976 SIK2 -0.57 -9.75 -0.47 7e-20 Primary sclerosing cholangitis; CRC cis rs9443645 0.901 rs1572584 chr6:79690290 A/G cg09184832 chr6:79620586 NA 0.5 9.1 0.45 8.56e-18 Intelligence (multi-trait analysis); CRC cis rs763121 0.853 rs5757141 chr22:38957483 G/A cg06022373 chr22:39101656 GTPBP1 0.72 10.63 0.51 6.88e-23 Menopause (age at onset); CRC cis rs10189230 0.967 rs1864460 chr2:222347655 A/C cg14652038 chr2:222343519 EPHA4 0.55 10.4 0.5 4.28e-22 Urate levels in lean individuals; CRC cis rs9311676 0.656 rs10866016 chr3:58390844 C/T cg06643156 chr3:58380774 PXK 0.41 6.33 0.33 7.82e-10 Systemic lupus erythematosus; CRC cis rs2404602 0.583 rs12908334 chr15:76581592 C/T cg00316803 chr15:76480434 C15orf27 -0.39 -6.69 -0.35 9.55e-11 Blood metabolite levels; CRC cis rs9837602 1.000 rs7620228 chr3:99790332 A/C cg07805332 chr3:99536008 MIR548G;C3orf26 -0.46 -5.9 -0.31 9.23e-9 Breast cancer; CRC cis rs6952808 0.929 rs2280548 chr7:1976667 G/T cg21782813 chr7:2030301 MAD1L1 0.48 7.85 0.4 6.04e-14 Bipolar disorder and schizophrenia; CRC cis rs365302 1.000 rs411523 chr6:159618790 G/A cg14500486 chr6:159655392 FNDC1 0.53 7.76 0.39 1.05e-13 Coronary heart disease; CRC cis rs9549260 0.755 rs7317254 chr13:41217849 A/G cg21288729 chr13:41239152 FOXO1 0.49 7.68 0.39 1.79e-13 Red blood cell count; CRC cis rs881375 0.867 rs6478487 chr9:123672777 C/T cg09419670 chr9:123605666 PSMD5;LOC253039 0.59 8.74 0.43 1.23e-16 Rheumatoid arthritis; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg02923393 chr16:1543003 TELO2 0.47 6.58 0.34 1.89e-10 Response to antipsychotic treatment; CRC cis rs4423214 0.592 rs3829251 chr11:71194559 G/A cg05163923 chr11:71159392 DHCR7 -0.57 -5.91 -0.31 8.38e-9 Vitamin D levels; CRC cis rs9486719 1.000 rs2145535 chr6:97034715 G/A cg18709589 chr6:96969512 KIAA0776 -0.52 -5.83 -0.31 1.3e-8 Migraine;Coronary artery disease; CRC cis rs6461049 0.800 rs3800909 chr7:2159594 C/G cg08027265 chr7:2291960 NA -0.36 -6.29 -0.33 9.91e-10 Schizophrenia; CRC cis rs4494114 0.967 rs9438986 chr1:39369652 T/G cg25970120 chr1:39325951 RRAGC -0.42 -5.63 -0.3 3.9e-8 Blood protein levels; CRC cis rs7020830 0.931 rs13293916 chr9:37136359 C/G cg14294708 chr9:37120828 ZCCHC7 1.2 26.62 0.83 4.51e-84 Schizophrenia; CRC cis rs11650494 0.908 rs77488129 chr17:47448970 G/A cg08112188 chr17:47440006 ZNF652 1.23 11.49 0.54 6.58e-26 Prostate cancer; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg08475517 chr19:2783460 SGTA 0.44 6.06 0.32 3.66e-9 Response to antipsychotic treatment; CRC cis rs7772486 0.790 rs9403749 chr6:146162239 A/G cg05347473 chr6:146136440 FBXO30 0.38 5.69 0.3 2.87e-8 Lobe attachment (rater-scored or self-reported); CRC cis rs6598955 0.724 rs12068388 chr1:26621596 G/A cg00852783 chr1:26633632 UBXN11 0.43 6.86 0.35 3.38e-11 Obesity-related traits; CRC cis rs2067615 0.579 rs4385986 chr12:107133775 C/T cg13491945 chr12:107078410 RFX4 0.34 5.86 0.31 1.09e-8 Heart rate; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg00683158 chr19:7660969 KIAA1543 0.48 7.02 0.36 1.25e-11 Response to antipsychotic treatment; CRC cis rs875971 0.862 rs10276077 chr7:65728411 A/G cg12463550 chr7:65579703 CRCP -0.52 -7.37 -0.38 1.38e-12 Aortic root size; CRC cis rs8180040 0.629 rs7426969 chr3:47091355 T/C cg10298567 chr3:47292165 KIF9 -0.4 -6.29 -0.33 1.04e-9 Colorectal cancer; CRC cis rs3806843 0.966 rs6891559 chr5:140145206 G/A cg16607685 chr5:140181889 PCDHA2;PCDHA1;PCDHA3 -0.28 -6.41 -0.33 5.1e-10 Depressive symptoms (multi-trait analysis); CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg09311052 chr1:154531418 UBE2Q1 -0.55 -6.74 -0.35 7.3e-11 Diisocyanate-induced asthma; CRC trans rs2727020 0.595 rs11040328 chr11:49339055 T/C cg15704280 chr7:45808275 SEPT13 -0.65 -9.95 -0.48 1.45e-20 Coronary artery disease; CRC cis rs4819052 0.851 rs2236443 chr21:46678174 T/C cg02159808 chr21:46707872 POFUT2;LOC642852 0.52 6.99 0.36 1.58e-11 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs1065656 0.563 rs391546 chr16:1915581 T/G cg09830162 chr16:1889614 FAHD1;C16orf73 0.54 8.08 0.41 1.23e-14 Insulin-like growth factors; CRC cis rs6066835 0.572 rs11698365 chr20:47259527 C/T cg18078177 chr20:47281410 PREX1 0.78 5.96 0.31 6.37e-9 Multiple myeloma; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg03945577 chr1:150602196 ENSA 0.45 6.26 0.33 1.21e-9 Response to antipsychotic treatment; CRC cis rs12530845 0.623 rs73721664 chr7:135343575 A/C cg23117316 chr7:135346802 PL-5283 -0.48 -6.16 -0.32 2.13e-9 Red blood cell traits; CRC cis rs2456568 0.900 rs1518571 chr11:93667420 C/A cg26875233 chr11:93583750 C11orf90 -0.33 -6.41 -0.33 4.93e-10 Response to serotonin reuptake inhibitors in major depressive disorder; CRC cis rs13256369 0.951 rs13259955 chr8:8565885 C/G cg06671706 chr8:8559999 CLDN23 0.62 9.28 0.46 2.32e-18 Obesity-related traits; CRC cis rs12477438 0.501 rs13000731 chr2:99795231 G/T cg26064155 chr2:99771622 LIPT1;TSGA10 0.77 13.13 0.59 5.79e-32 Chronic sinus infection; CRC cis rs847649 1.000 rs4620204 chr7:102594217 T/C cg18108683 chr7:102477205 FBXL13 0.58 9.37 0.46 1.19e-18 Morning vs. evening chronotype; CRC cis rs10751667 0.621 rs10794348 chr11:939941 G/A ch.11.42038R chr11:967971 AP2A2 0.61 10.38 0.5 4.91e-22 Alzheimer's disease (late onset); CRC cis rs2882667 0.690 rs1703212 chr5:138078552 A/G cg09476006 chr5:138032270 NA -0.57 -10.31 -0.49 8.67e-22 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs734999 0.545 rs3890745 chr1:2553624 C/T cg18854424 chr1:2615690 NA -0.41 -7.78 -0.39 9.21e-14 Ulcerative colitis; CRC cis rs4713118 0.955 rs9468201 chr6:27687035 C/T cg20933634 chr6:27740509 NA 0.57 8.07 0.41 1.33e-14 Parkinson's disease; CRC trans rs12702919 0.837 rs2713339 chr7:9548713 C/A cg15597424 chr4:24472487 NA -0.39 -6.32 -0.33 8.56e-10 PR interval in Tripanosoma cruzi seropositivity; CRC cis rs2153535 0.580 rs763376 chr6:8492776 G/A cg21535247 chr6:8435926 SLC35B3 0.49 7.39 0.38 1.21e-12 Motion sickness; CRC cis rs1878931 0.697 rs10048148 chr16:3417450 C/G cg26668626 chr16:3451006 ZNF174;ZNF434 0.91 15.39 0.65 1.25e-40 Body mass index (adult); CRC cis rs758324 0.947 rs7734536 chr5:131162124 C/T cg25547332 chr5:131281432 NA 0.39 5.73 0.3 2.25e-8 Alzheimer's disease in APOE e4- carriers; CRC cis rs7493 0.853 rs35686517 chr7:95052611 G/A cg04155289 chr7:94953770 PON1 -0.63 -7.73 -0.39 1.32e-13 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs10504229 1.000 rs67895971 chr8:58177994 A/G cg22535103 chr8:58192502 C8orf71 -0.82 -12.27 -0.56 9.63e-29 Developmental language disorder (linguistic errors); CRC cis rs875971 0.619 rs2302918 chr7:66000932 A/G cg05627663 chr7:65219948 SNORA22;CCT6P1 0.45 6.67 0.35 1.09e-10 Aortic root size; CRC cis rs853679 0.517 rs7755442 chr6:28039015 T/C cg21251018 chr6:28226885 NKAPL 0.46 6.12 0.32 2.73e-9 Depression; CRC cis rs9894429 0.646 rs12948797 chr17:79617384 G/A cg09655341 chr17:79618100 PDE6G -0.37 -6.24 -0.33 1.38e-9 Eye color traits; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg16585985 chr1:161360266 NA 0.42 6.31 0.33 9.13e-10 Intelligence (multi-trait analysis); CRC cis rs9788333 0.888 rs35880230 chr13:21885972 A/G cg23743428 chr13:21893420 NA -0.47 -9.09 -0.45 9.81e-18 Thiazide-induced adverse metabolic effects in hypertensive patients; CRC cis rs250677 0.687 rs250671 chr5:148446523 T/C cg18129178 chr5:148520854 ABLIM3 -0.36 -5.64 -0.3 3.72e-8 Breast cancer; CRC cis rs6840360 0.642 rs2724551 chr4:152355383 T/C cg09659197 chr4:152720779 NA 0.34 6.66 0.34 1.14e-10 Intelligence (multi-trait analysis); CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg24833071 chr7:75115655 POM121C 0.37 6.01 0.31 4.81e-9 Obesity-related traits; CRC cis rs12681287 0.640 rs13261901 chr8:87478717 G/C cg27223183 chr8:87520930 FAM82B -0.53 -7.52 -0.38 5.31e-13 Caudate activity during reward; CRC cis rs7580658 0.724 rs6712446 chr2:127998399 G/T cg09760422 chr2:128146352 NA -0.36 -7.06 -0.36 9.73e-12 Protein C levels; CRC cis rs853679 0.542 rs9393892 chr6:28081394 A/G cg15786705 chr6:28176104 NA 0.74 9.27 0.46 2.5e-18 Depression; CRC cis rs10751667 0.600 rs10794342 chr11:924904 C/T cg06064525 chr11:970664 AP2A2 -0.33 -6.66 -0.34 1.18e-10 Alzheimer's disease (late onset); CRC cis rs11626933 1.000 rs11621007 chr14:90743967 G/A cg14092571 chr14:90743983 NA -0.94 -15.38 -0.65 1.29e-40 Gut microbiota (bacterial taxa); CRC cis rs1190552 0.846 rs11623570 chr14:102959277 G/T cg18135206 chr14:102964638 TECPR2 0.55 6.77 0.35 6e-11 Blood protein levels; CRC trans rs1814175 0.817 rs10839397 chr11:49857074 C/T cg11707556 chr5:10655725 ANKRD33B -0.42 -7.87 -0.4 5.18e-14 Height; CRC cis rs10791323 0.660 rs2156681 chr11:133731644 G/T cg06766960 chr11:133703094 NA -0.41 -7.44 -0.38 8.81e-13 Childhood ear infection; CRC cis rs7659604 0.539 rs2221628 chr4:122795361 G/A cg20573242 chr4:122745356 CCNA2 0.56 8.36 0.42 1.76e-15 Type 2 diabetes; CRC cis rs1046896 0.553 rs2292965 chr17:80900645 G/A cg08200770 chr17:80723486 TBCD -0.45 -6.77 -0.35 5.85e-11 Glycated hemoglobin levels; CRC cis rs752010 0.841 rs17363834 chr1:42076607 C/T cg06885757 chr1:42089581 HIVEP3 0.33 5.86 0.31 1.13e-8 Lupus nephritis in systemic lupus erythematosus; CRC cis rs2153535 0.560 rs9379214 chr6:8480870 T/C cg21535247 chr6:8435926 SLC35B3 0.49 7.38 0.38 1.3e-12 Motion sickness; CRC cis rs2404602 0.692 rs12902452 chr15:76921465 T/C cg23625390 chr15:77176239 SCAPER 0.48 7.06 0.36 9.99e-12 Blood metabolite levels; CRC cis rs3750082 0.889 rs3750081 chr7:32930876 T/G cg05721444 chr7:32995514 FKBP9 0.51 7.9 0.4 4.28e-14 Glomerular filtration rate (creatinine); CRC cis rs72772090 0.520 rs56325109 chr5:96112295 C/T cg17330273 chr5:96107758 CAST;ERAP1 -0.66 -6.04 -0.32 4.12e-9 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs514406 0.505 rs856721 chr1:53162156 C/A cg24675658 chr1:53192096 ZYG11B -0.68 -10.24 -0.49 1.53e-21 Monocyte count; CRC cis rs71403859 0.554 rs12373065 chr16:71870032 T/A cg08717414 chr16:71523259 ZNF19 -0.88 -7.45 -0.38 8.19e-13 Post bronchodilator FEV1; CRC cis rs2046867 0.862 rs35178407 chr3:72799703 C/T cg25664220 chr3:72788482 NA -0.4 -6.09 -0.32 3.22e-9 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; CRC cis rs910316 0.935 rs2268620 chr14:75640403 G/A cg11812906 chr14:75593930 NEK9 -0.61 -9.39 -0.46 1.05e-18 Height; CRC cis rs10971721 0.822 rs118115128 chr9:33935449 G/A cg13495928 chr9:33750294 PRSS3 0.56 5.95 0.31 6.96e-9 Body mass index; CRC cis rs6598955 0.543 rs112752634 chr1:26534217 G/A cg04990556 chr1:26633338 UBXN11 0.82 9.58 0.47 2.49e-19 Obesity-related traits; CRC cis rs17767392 1.000 rs17767392 chr14:71764777 C/T cg13720639 chr14:72061746 SIPA1L1 -0.53 -6.81 -0.35 4.7e-11 Mitral valve prolapse; CRC cis rs6500395 1.000 rs28577888 chr16:48673281 T/G cg04672837 chr16:48644449 N4BP1 0.45 6.73 0.35 7.64e-11 Response to tocilizumab in rheumatoid arthritis; CRC trans rs7647973 0.626 rs1078341 chr3:49685592 A/G cg21659725 chr3:3221576 CRBN -0.63 -7.18 -0.37 4.53e-12 Menarche (age at onset); CRC cis rs875971 0.545 rs73376401 chr7:65639828 G/A cg11764359 chr7:65958608 NA 0.47 6.05 0.32 4e-9 Aortic root size; CRC cis rs4555082 0.957 rs3000073 chr14:105729792 G/A cg13114125 chr14:105738426 BRF1 -0.75 -11.38 -0.53 1.61e-25 Mean platelet volume;Platelet distribution width; CRC cis rs12410462 0.681 rs114950580 chr1:227673334 G/C cg23173402 chr1:227635558 NA 0.86 7.04 0.36 1.14e-11 Major depressive disorder; CRC trans rs7937682 1.000 rs11608149 chr11:111535102 G/A cg18187862 chr3:45730750 SACM1L -0.55 -7.65 -0.39 2.29e-13 Primary sclerosing cholangitis; CRC cis rs6502050 0.835 rs34960918 chr17:80113925 A/G cg25804541 chr17:80189381 SLC16A3 -0.31 -5.97 -0.31 6.08e-9 Life satisfaction; CRC cis rs6585424 1.000 rs2304410 chr10:81921810 T/C cg11900509 chr10:81946545 ANXA11 -0.72 -8.81 -0.44 7.22e-17 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs4604732 0.631 rs12039596 chr1:247624766 A/G cg12754571 chr1:247694271 LOC148824;OR2C3 0.42 5.92 0.31 7.9e-9 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CRC cis rs12586317 0.547 rs10134907 chr14:35499211 A/C cg05294307 chr14:35346193 BAZ1A -0.69 -7.47 -0.38 7.35e-13 Psoriasis; CRC trans rs208520 0.874 rs208491 chr6:66928459 C/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.93 -12.01 -0.55 8.16e-28 Exhaled nitric oxide output; CRC cis rs2243480 1.000 rs160655 chr7:65533214 T/C cg18252515 chr7:66147081 NA -1.12 -13.21 -0.59 3.05e-32 Diabetic kidney disease; CRC cis rs9660180 0.967 rs6603802 chr1:1812521 C/T cg03396347 chr1:1875803 NA -0.62 -9.7 -0.47 9.63e-20 Body mass index; CRC cis rs9648716 1.000 rs7785306 chr7:140619488 C/T cg10747023 chr7:140774559 NA 0.46 6.03 0.32 4.51e-9 Type 2 diabetes; CRC cis rs1129187 0.755 rs4714638 chr6:42917017 A/G cg26304593 chr6:42947056 PEX6 -0.44 -6.23 -0.32 1.46e-9 Alzheimer's disease in APOE e4+ carriers; CRC trans rs7618501 1.000 rs9855505 chr3:49792158 T/G cg21582582 chr3:182698605 DCUN1D1 -0.57 -8.4 -0.42 1.38e-15 Intelligence (multi-trait analysis); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg16956745 chr1:36689900 THRAP3 0.45 6.47 0.34 3.64e-10 Intelligence (multi-trait analysis); CRC cis rs9894429 0.608 rs7406382 chr17:79597786 T/C cg21984481 chr17:79567631 NPLOC4 -0.46 -7.98 -0.4 2.47e-14 Eye color traits; CRC cis rs28386778 0.897 rs2727323 chr17:61921999 G/T cg25654072 chr17:61904446 PSMC5;FTSJ3 0.7 10.94 0.52 5.62e-24 Prudent dietary pattern; CRC cis rs9911578 0.933 rs2632508 chr17:56533235 G/A cg12560992 chr17:57184187 TRIM37 0.91 16.6 0.68 2.2e-45 Intelligence (multi-trait analysis); CRC cis rs8180040 0.681 rs9818382 chr3:47193034 C/T cg02527881 chr3:46936655 PTH1R -0.35 -6.09 -0.32 3.07e-9 Colorectal cancer; CRC cis rs55665837 0.559 rs11023210 chr11:14422762 A/G cg19336497 chr11:14380999 RRAS2 0.43 7.41 0.38 1.05e-12 Vitamin D levels; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg05697231 chr15:74286614 PML 0.41 6.07 0.32 3.6e-9 Intelligence (multi-trait analysis); CRC cis rs7647973 1.000 rs9842132 chr3:49427933 G/A cg07636037 chr3:49044803 WDR6 -0.65 -7.81 -0.4 7.8e-14 Menarche (age at onset); CRC cis rs9322193 0.884 rs62439837 chr6:149991516 G/T cg07701084 chr6:150067640 NUP43 0.56 7.86 0.4 5.47e-14 Lung cancer; CRC cis rs11628318 0.853 rs4906226 chr14:103027359 C/T cg23071808 chr14:103021642 NA -0.72 -9.36 -0.46 1.32e-18 Platelet count; CRC cis rs875971 0.522 rs7784623 chr7:65395034 T/G cg18876405 chr7:65276391 NA 0.65 11.95 0.55 1.41e-27 Aortic root size; CRC cis rs769267 0.965 rs4808937 chr19:19398005 A/G cg20644253 chr19:19431407 KIAA0892;SF4 0.42 5.88 0.31 1.01e-8 Tonsillectomy; CRC cis rs6952808 0.789 rs35729895 chr7:1885069 C/T cg02951883 chr7:2050386 MAD1L1 -0.64 -10.44 -0.5 3.12e-22 Bipolar disorder and schizophrenia; CRC cis rs28456 1 rs28456 chr11:61589481 A/G cg06781209 chr11:61594997 FADS2 -0.41 -5.87 -0.31 1.04e-8 Bipolar disorder; CRC cis rs7927592 0.763 rs3740628 chr11:68381415 A/G cg16797656 chr11:68205561 LRP5 0.48 8.96 0.44 2.46e-17 Total body bone mineral density; CRC cis rs6681460 0.932 rs536410 chr1:67191084 C/T cg02459107 chr1:67143332 SGIP1 0.4 7.28 0.37 2.54e-12 Presence of antiphospholipid antibodies; CRC cis rs891088 0.695 rs10411728 chr19:7194938 C/T cg00428638 chr19:7224713 INSR -0.63 -7.75 -0.39 1.18e-13 Hip circumference adjusted for BMI;Height; CRC trans rs4942242 0.663 rs7332737 chr13:44215043 C/T cg27382691 chr15:76552771 ETFA;TYRO3P -0.47 -6.12 -0.32 2.62e-9 Response to tocilizumab in rheumatoid arthritis; CRC cis rs6951245 0.872 rs74360401 chr7:1067403 G/A cg24642844 chr7:1081250 C7orf50 -0.78 -9.35 -0.46 1.42e-18 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg05742564 chr16:23568708 UBFD1;EARS2 -0.44 -6.43 -0.33 4.43e-10 Myopia (pathological); CRC cis rs17209837 0.607 rs45478299 chr7:87111321 G/A cg00919237 chr7:87102261 ABCB4 -0.51 -6.7 -0.35 9.12e-11 Gallbladder cancer; CRC cis rs6074578 0.740 rs1858599 chr20:147917 A/C cg16931068 chr20:139680 DEFB127 0.3 5.63 0.3 3.91e-8 Hirschsprung disease; CRC cis rs9549260 0.755 rs3900833 chr13:41188292 A/G cg21288729 chr13:41239152 FOXO1 0.42 6.52 0.34 2.61e-10 Red blood cell count; CRC cis rs2404602 0.647 rs35710279 chr15:77082234 T/A cg23625390 chr15:77176239 SCAPER -0.85 -13.02 -0.58 1.48e-31 Blood metabolite levels; CRC cis rs992157 0.735 rs13430006 chr2:219113089 A/C cg04731861 chr2:219085781 ARPC2 0.32 6.84 0.35 3.9e-11 Colorectal cancer; CRC cis rs4237845 0.761 rs11172378 chr12:58298161 C/T cg02175503 chr12:58329896 NA 0.55 7.23 0.37 3.42e-12 Intelligence (multi-trait analysis); CRC cis rs1451375 0.755 rs6969081 chr7:50624505 A/T cg14593290 chr7:50529359 DDC 0.5 7.34 0.38 1.64e-12 Malaria; CRC cis rs2386661 0.547 rs57893347 chr10:5646191 G/A cg17085576 chr10:5658249 NA -0.43 -6.18 -0.32 1.89e-9 Breast cancer; CRC cis rs9462846 0.919 rs6936722 chr6:42891311 A/G cg21280719 chr6:42927975 GNMT 0.32 6.1 0.32 3.03e-9 Blood protein levels; CRC cis rs1065852 0.526 rs9607869 chr22:42418110 T/A cg22189786 chr22:42395067 WBP2NL 0.43 6.17 0.32 2.02e-9 Response to serotonin reuptake inhibitors in major depressive disorder (plasma drug and metabolite levels); CRC cis rs1707322 1.000 rs785517 chr1:46567535 A/T cg03146154 chr1:46216737 IPP -0.6 -8.09 -0.41 1.18e-14 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs6558530 0.692 rs6558525 chr8:1702523 A/G cg19131313 chr8:1704013 NA -0.49 -6.08 -0.32 3.42e-9 Systolic blood pressure; CRC cis rs2440129 0.611 rs1126667 chr17:6902760 C/T cg03762994 chr17:6899332 ALOX12 -0.62 -11.57 -0.54 3.4e-26 Tonsillectomy; CRC trans rs4650994 0.935 rs12039531 chr1:178515612 G/A cg05059571 chr16:84539110 KIAA1609 -0.48 -7.34 -0.38 1.63e-12 HDL cholesterol levels;HDL cholesterol; CRC cis rs4665809 1.000 rs4665305 chr2:26313524 C/T cg22920501 chr2:26401640 FAM59B -0.51 -7.07 -0.36 9.42e-12 Gut microbiome composition (summer); CRC cis rs1577917 0.740 rs9353327 chr6:86394066 C/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.57 -8.0 -0.4 2.21e-14 Response to antipsychotic treatment; CRC cis rs4474465 0.736 rs4945291 chr11:78254413 C/T cg02023728 chr11:77925099 USP35 -0.35 -5.99 -0.31 5.35e-9 Alzheimer's disease (survival time); CRC trans rs2228479 0.850 rs12596934 chr16:89841605 T/G cg21302420 chr1:112162376 RAP1A 0.72 5.96 0.31 6.33e-9 Skin colour saturation; CRC cis rs28386778 0.897 rs2584608 chr17:61936710 A/G cg06601766 chr17:61851465 DDX42;CCDC47 0.43 5.86 0.31 1.14e-8 Prudent dietary pattern; CRC cis rs172166 0.694 rs1150666 chr6:28123928 T/C cg23161317 chr6:28129485 ZNF389 0.46 6.5 0.34 2.93e-10 Cardiac Troponin-T levels; CRC trans rs4263408 0.934 rs9683743 chr4:39703194 A/C cg16687227 chr3:58477487 KCTD6 -0.41 -6.07 -0.32 3.6e-9 Plasma amyloid beta peptide concentrations (ABx-40); CRC cis rs2019137 0.936 rs3811059 chr2:113962071 C/T cg21482265 chr2:113992762 PAX8;LOC440839;LOC654433 -0.48 -6.78 -0.35 5.48e-11 Lymphocyte counts; CRC cis rs12913538 0.519 rs7168691 chr15:62888952 A/T cg09983546 chr15:62884068 NA 0.51 6.14 0.32 2.38e-9 Sleep depth; CRC cis rs514406 0.861 rs11206011 chr1:53235910 T/C cg25767906 chr1:53392781 SCP2 0.4 6.54 0.34 2.39e-10 Monocyte count; CRC cis rs7769051 0.711 rs9493436 chr6:133088275 T/C cg07930552 chr6:133119739 C6orf192 0.57 6.78 0.35 5.67e-11 Type 2 diabetes nephropathy; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg20584198 chr12:57637690 STAC3 0.51 7.0 0.36 1.43e-11 Thyroid stimulating hormone; CRC cis rs3820068 0.705 rs4646091 chr1:15822043 T/C cg27534772 chr1:16042836 PLEKHM2 0.41 6.95 0.36 1.99e-11 Systolic blood pressure; CRC cis rs6951245 0.529 rs10262070 chr7:1141738 C/T cg18402987 chr7:1209562 NA 0.53 6.41 0.33 5.02e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs4237845 0.844 rs7306124 chr12:58303349 A/T cg00677455 chr12:58241039 CTDSP2 0.54 8.2 0.41 5.29e-15 Intelligence (multi-trait analysis); CRC cis rs9393692 0.645 rs2179152 chr6:26325888 T/C cg00631329 chr6:26305371 NA -0.71 -12.76 -0.58 1.39e-30 Educational attainment; CRC cis rs9311474 0.508 rs6786043 chr3:52604861 A/G cg10802521 chr3:52805072 NEK4 -0.58 -9.23 -0.45 3.45e-18 Electroencephalogram traits; CRC trans rs7618501 0.633 rs2526751 chr3:50064867 T/C cg21665057 chr3:196295764 WDR53;FBXO45 -0.61 -9.71 -0.47 8.9e-20 Intelligence (multi-trait analysis); CRC cis rs875971 0.522 rs781144 chr7:65440344 C/G cg11764359 chr7:65958608 NA 0.51 7.84 0.4 6.37e-14 Aortic root size; CRC cis rs12753569 0.748 rs1013630 chr1:76513819 G/T cg00791851 chr1:76518896 NA 0.38 6.91 0.36 2.56e-11 Personality dimensions; CRC cis rs881375 0.967 rs2239658 chr9:123671837 A/G cg00246817 chr9:123691163 NA -0.44 -5.64 -0.3 3.72e-8 Rheumatoid arthritis; CRC cis rs10504229 0.775 rs72650869 chr8:58157923 T/A cg08219700 chr8:58056026 NA 0.46 5.72 0.3 2.37e-8 Developmental language disorder (linguistic errors); CRC cis rs142483589 1 rs142483589 chr9:139320323 CCG/C cg14119001 chr9:139324193 INPP5E -0.5 -7.21 -0.37 3.94e-12 White blood cell count; CRC cis rs1799949 1.000 rs8176273 chr17:41211653 A/G cg05368731 chr17:41323189 NBR1 0.65 9.48 0.46 5.19e-19 Menopause (age at onset); CRC cis rs67478160 0.634 rs2024669 chr14:104275602 G/C cg08213375 chr14:104286397 PPP1R13B 0.57 11.69 0.54 1.22e-26 Schizophrenia; CRC cis rs10256972 0.758 rs9801444 chr7:1080444 A/C cg07308232 chr7:1071921 C7orf50 0.49 6.94 0.36 2.15e-11 Longevity;Endometriosis; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg08400120 chr3:169940839 PRKCI 0.49 6.44 0.33 4.3e-10 Thyroid stimulating hormone; CRC cis rs6952808 0.689 rs2008263 chr7:2048335 A/G cg19624444 chr7:2048497 MAD1L1 0.33 5.88 0.31 1.02e-8 Bipolar disorder and schizophrenia; CRC cis rs2949837 0.581 rs2949838 chr7:45993924 T/C cg15898840 chr7:45960834 IGFBP3 0.47 7.92 0.4 3.77e-14 Sitting height ratio; CRC cis rs6032067 0.777 rs62208382 chr20:43785549 C/T cg10761708 chr20:43804764 PI3 0.48 5.62 0.3 4.06e-8 Blood protein levels; CRC cis rs6860806 0.632 rs4330455 chr5:131586349 T/C cg02033258 chr5:131593261 PDLIM4 0.4 7.59 0.39 3.34e-13 Breast cancer; CRC cis rs9381040 0.626 rs2272986 chr6:41037778 C/T cg25110423 chr6:41068646 NFYA;LOC221442 -0.4 -6.04 -0.32 4.23e-9 Alzheimer's disease (late onset); CRC trans rs10982213 0.830 rs2274163 chr9:117188714 C/T cg00515161 chr17:59940900 BRIP1 -0.45 -6.89 -0.36 2.81e-11 Interleukin-6 levels; CRC cis rs7927771 0.965 rs17788930 chr11:47752775 A/G cg05585544 chr11:47624801 NA -0.61 -10.75 -0.51 2.56e-23 Subjective well-being; CRC cis rs9814567 1.000 rs7356093 chr3:134238753 T/C cg06541857 chr3:134203789 ANAPC13;CEP63 -0.41 -6.27 -0.33 1.16e-9 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs4604732 0.631 rs1106719 chr1:247624713 A/G cg12758973 chr1:247694275 LOC148824;OR2C3 -0.43 -6.26 -0.33 1.2e-9 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CRC cis rs35520189 0.591 rs11690185 chr2:113698136 C/T cg12858261 chr2:113808755 IL1F8 0.47 6.28 0.33 1.05e-9 Obstructive sleep apnea trait (apnea hypopnea index); CRC cis rs4321325 0.733 rs78238478 chr2:127936306 G/A cg11380483 chr2:127933992 NA 0.63 7.44 0.38 8.6e-13 Protein C levels; CRC cis rs9487051 0.735 rs1260594 chr6:109519891 A/C cg21918786 chr6:109611834 NA -0.35 -6.01 -0.31 4.88e-9 Reticulocyte fraction of red cells; CRC trans rs9784649 0.891 rs57762467 chr5:25025700 C/T cg08600765 chr20:34638493 LOC647979 -0.62 -7.06 -0.36 1.01e-11 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs58688157 0.705 rs12419618 chr11:611531 G/A cg01842473 chr11:617407 IRF7;MUPCDH -0.54 -6.38 -0.33 5.93e-10 Systemic lupus erythematosus; CRC cis rs17234274 0.622 rs1384480 chr11:23237995 C/G cg05245346 chr11:23248277 NA 0.34 5.63 0.3 3.79e-8 Cancer; CRC cis rs4972806 0.849 rs2857541 chr2:177029086 C/T cg03152288 chr2:177042942 NA 0.8 12.66 0.57 3.41e-30 IgG glycosylation; CRC cis rs1577917 0.958 rs884842 chr6:86680397 A/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.51 -6.75 -0.35 6.53e-11 Response to antipsychotic treatment; CRC cis rs2243480 0.901 rs73148097 chr7:65431787 A/C cg12463550 chr7:65579703 CRCP 0.66 6.24 0.33 1.31e-9 Diabetic kidney disease; CRC cis rs13191362 0.935 rs67084568 chr6:162988548 C/A cg23758597 chr6:163146217 PARK2 -0.56 -6.18 -0.32 1.93e-9 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs3806843 1.000 rs2240692 chr5:140183585 A/G cg19875535 chr5:140030758 IK 0.63 10.19 0.49 2.26e-21 Depressive symptoms (multi-trait analysis); CRC trans rs6076960 0.622 rs6054063 chr20:6262992 C/A cg21095983 chr6:86352623 SYNCRIP 0.48 6.83 0.35 4.16e-11 Smooth-surface caries; CRC cis rs7666738 0.830 rs62321597 chr4:99014221 C/A cg17366294 chr4:99064904 C4orf37 0.44 7.36 0.38 1.5e-12 Colonoscopy-negative controls vs population controls; CRC cis rs9443645 0.901 rs6937465 chr6:79570345 G/T cg09184832 chr6:79620586 NA -0.5 -9.44 -0.46 7.12e-19 Intelligence (multi-trait analysis); CRC cis rs9768139 0.903 rs28503558 chr7:158119568 C/T cg24154853 chr7:158122151 PTPRN2 -0.59 -9.85 -0.48 3.18e-20 Calcium levels; CRC cis rs7705042 1.000 rs7705042 chr5:141492419 C/A cg07392085 chr5:141489673 NDFIP1 0.47 7.41 0.38 1.06e-12 Asthma; CRC cis rs1443512 0.812 rs1561987 chr12:54335268 C/T cg17410650 chr12:54324560 NA -0.33 -5.92 -0.31 8.06e-9 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for BMI in non-smokers;Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction);Waist-hip ratio;Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour); CRC trans rs62103177 0.733 rs62096747 chr18:77619568 A/G cg05926928 chr17:57297772 GDPD1 1.02 10.13 0.49 3.7e-21 Opioid sensitivity; CRC trans rs1005277 0.579 rs2474563 chr10:38375938 T/C cg11292332 chr7:45801988 SEPT13 -0.35 -6.21 -0.32 1.58e-9 Extrinsic epigenetic age acceleration; CRC cis rs62045849 0.546 rs71395385 chr16:89196279 A/G cg08015503 chr16:89190385 ACSF3 0.95 6.22 0.32 1.48e-9 Red blood cell count; CRC cis rs2239547 0.522 rs9842974 chr3:53011050 C/A cg11645453 chr3:52864694 ITIH4 0.52 9.15 0.45 6.07e-18 Schizophrenia; CRC cis rs4243830 0.522 rs11122086 chr1:6601246 T/G cg22792644 chr1:6614718 TAS1R1;NOL9 -0.8 -9.59 -0.47 2.33e-19 Body mass index; CRC cis rs9467711 0.517 rs16901784 chr6:26555433 C/A cg12315302 chr6:26189340 HIST1H4D 0.75 6.25 0.33 1.31e-9 Autism spectrum disorder or schizophrenia; CRC cis rs9488822 0.676 rs873879 chr6:116391259 A/G cg15226275 chr6:116381976 FRK 0.31 8.66 0.43 2.11e-16 Cholesterol, total;LDL cholesterol; CRC cis rs7191439 0.858 rs8044367 chr16:88783374 A/G cg02389323 chr16:88786976 FAM38A 0.98 8.97 0.44 2.31e-17 Plateletcrit; CRC cis rs7618915 0.547 rs2336542 chr3:52710636 A/G cg05573699 chr3:52720067 GNL3;PBRM1 -0.47 -6.77 -0.35 6.02e-11 Bipolar disorder; CRC cis rs208520 0.874 rs208485 chr6:66925654 T/C cg07460842 chr6:66804631 NA -0.94 -12.2 -0.56 1.65e-28 Exhaled nitric oxide output; CRC trans rs17685 0.753 rs1859791 chr7:75786043 T/C cg19862616 chr7:65841803 NCRNA00174 0.98 18.08 0.71 3.12e-51 Coffee consumption;Coffee consumption (cups per day); CRC cis rs2153535 0.580 rs9393025 chr6:8490618 G/A cg21535247 chr6:8435926 SLC35B3 0.5 7.54 0.38 4.72e-13 Motion sickness; CRC cis rs6547741 0.935 rs4260197 chr2:27794150 C/G cg27432699 chr2:27873401 GPN1 -0.74 -13.44 -0.6 3.92e-33 Oral cavity cancer; CRC cis rs4665809 1.000 rs4665305 chr2:26313524 C/T cg26119090 chr2:26468346 HADHA;HADHB -0.6 -7.93 -0.4 3.38e-14 Gut microbiome composition (summer); CRC cis rs738322 1.000 rs133012 chr22:38570721 G/A cg25457927 chr22:38595422 NA -0.35 -7.4 -0.38 1.13e-12 Cutaneous nevi; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg02668984 chr17:48172022 PDK2 0.49 6.43 0.33 4.54e-10 Thyroid stimulating hormone; CRC cis rs950169 1.000 rs35648189 chr15:84740748 T/C cg03959625 chr15:84868606 LOC388152 0.41 6.08 0.32 3.26e-9 Schizophrenia; CRC cis rs2404602 0.583 rs2469542 chr15:76557476 A/G cg00316803 chr15:76480434 C15orf27 0.39 6.85 0.35 3.72e-11 Blood metabolite levels; CRC cis rs4731207 0.596 rs1031956 chr7:124627183 G/T cg23710748 chr7:124431027 NA -0.39 -6.16 -0.32 2.1e-9 Cutaneous malignant melanoma; CRC cis rs950776 0.593 rs481134 chr15:78877563 C/T cg06917634 chr15:78832804 PSMA4 0.59 9.22 0.45 3.66e-18 Sudden cardiac arrest; CRC trans rs747782 0.528 rs7937670 chr11:48313216 C/T cg27395922 chr11:50257633 LOC441601 0.48 6.14 0.32 2.4e-9 Intraocular pressure; CRC cis rs477895 0.653 rs72918475 chr11:63878644 G/C cg01518246 chr11:63870912 FLRT1;MACROD1 0.47 6.04 0.32 4.27e-9 Mean platelet volume; CRC trans rs66573146 1.000 rs56350643 chr4:7017591 G/A cg07817883 chr1:32538562 TMEM39B 1.49 11.99 0.55 9.79e-28 Granulocyte percentage of myeloid white cells; CRC cis rs904251 0.523 rs2776874 chr6:37483197 C/T cg01843034 chr6:37503916 NA -0.44 -8.32 -0.42 2.31e-15 Cognitive performance; CRC cis rs17376456 0.825 rs67328989 chr5:93243133 T/A cg09848695 chr5:92956644 FAM172A;MIR2277 0.67 6.07 0.32 3.51e-9 Diabetic retinopathy; CRC cis rs9660992 0.573 rs1172158 chr1:205208948 G/A cg00857998 chr1:205179979 DSTYK 0.43 5.69 0.3 2.83e-8 Mean corpuscular volume;Mean platelet volume; CRC cis rs4481887 0.861 rs4575112 chr1:248473534 A/G cg13385794 chr1:248469461 NA 0.38 6.75 0.35 6.84e-11 Common traits (Other); CRC cis rs12479064 0.694 rs4341989 chr2:100046783 C/T cg14399236 chr2:99771627 LIPT1;TSGA10 -0.68 -8.57 -0.43 4.05e-16 Chronic sinus infection; CRC cis rs6694672 1.000 rs857026 chr1:197012194 T/C cg13682187 chr1:196946512 CFHR5 0.43 6.87 0.35 3.23e-11 Asthma; CRC cis rs853679 0.517 rs9368555 chr6:28108967 T/C cg06470822 chr6:28175283 NA 1.03 13.59 0.6 1.04e-33 Depression; CRC trans rs561341 0.609 rs11658984 chr17:30186612 C/T cg20587970 chr11:113659929 NA 0.69 8.73 0.43 1.34e-16 Hip circumference adjusted for BMI; CRC cis rs477895 1.000 rs1047206 chr11:64089216 C/G cg04317338 chr11:64019027 PLCB3 0.61 5.98 0.31 5.71e-9 Mean platelet volume; CRC cis rs7827545 0.644 rs7386524 chr8:135534005 T/C cg17885191 chr8:135476712 NA -0.58 -7.58 -0.39 3.58e-13 Hypertension (SNP x SNP interaction); CRC cis rs7587476 0.689 rs10498025 chr2:215749256 A/G cg04004882 chr2:215674386 BARD1 0.66 9.02 0.45 1.62e-17 Neuroblastoma; CRC cis rs7666738 0.753 rs1830230 chr4:99026186 G/C cg17366294 chr4:99064904 C4orf37 0.44 7.43 0.38 9.49e-13 Colonoscopy-negative controls vs population controls; CRC cis rs2153535 0.580 rs7341201 chr6:8470270 T/C cg21535247 chr6:8435926 SLC35B3 0.5 7.53 0.38 4.89e-13 Motion sickness; CRC cis rs704795 0.836 rs1083865 chr2:27620827 A/G cg24768116 chr2:27665128 KRTCAP3 -0.36 -8.07 -0.41 1.38e-14 Menopause (age at onset); CRC cis rs826838 1.000 rs11169031 chr12:39056738 T/C cg26384229 chr12:38710491 ALG10B 0.72 10.12 0.49 3.77e-21 Heart rate; CRC cis rs6963495 0.745 rs73192152 chr7:105212258 A/C cg13798780 chr7:105162888 PUS7 0.63 7.2 0.37 4.02e-12 Bipolar disorder (body mass index interaction); CRC cis rs13256369 1.000 rs9329166 chr8:8576655 C/T cg06636001 chr8:8085503 FLJ10661 0.53 6.37 0.33 6.51e-10 Obesity-related traits; CRC cis rs2153535 0.580 rs986060 chr6:8465428 T/C cg21535247 chr6:8435926 SLC35B3 0.5 7.53 0.38 4.89e-13 Motion sickness; CRC trans rs9291683 0.609 rs36084205 chr4:10028678 A/C cg26043149 chr18:55253948 FECH 0.53 8.12 0.41 9.3e-15 Bone mineral density; CRC cis rs7772486 0.686 rs2328708 chr6:146095739 G/A cg23711669 chr6:146136114 FBXO30 -0.66 -11.05 -0.52 2.37e-24 Lobe attachment (rater-scored or self-reported); CRC cis rs6951245 0.786 rs77943789 chr7:1140158 C/T cg18402987 chr7:1209562 NA 0.64 7.24 0.37 3.12e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg18555811 chr3:193852889 HES1 0.4 6.15 0.32 2.2e-9 Liver disease severity in Alagille syndrome; CRC cis rs62408225 0.802 rs2325261 chr6:90921407 T/C cg06866423 chr6:90926672 BACH2 0.69 13.03 0.58 1.38e-31 Eosinophil counts;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC cis rs3736485 0.966 rs4775959 chr15:51891636 T/C cg08986416 chr15:51914746 DMXL2 -0.45 -6.46 -0.34 3.79e-10 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs4713118 0.869 rs9283881 chr6:27715255 A/T cg03623178 chr6:28175578 NA 0.67 9.51 0.46 4.25e-19 Parkinson's disease; CRC cis rs17767392 0.881 rs35971049 chr14:72012219 T/A cg13720639 chr14:72061746 SIPA1L1 -0.54 -7.01 -0.36 1.32e-11 Mitral valve prolapse; CRC cis rs910187 0.605 rs6066224 chr20:45806632 T/A cg27589058 chr20:45804311 EYA2 -0.44 -8.59 -0.43 3.49e-16 Migraine; CRC cis rs3796352 1.000 rs71301809 chr3:53090312 C/T cg06204229 chr3:52865917 ITIH4 0.5 5.93 0.31 7.74e-9 Immune reponse to smallpox (secreted IL-2); CRC cis rs10992471 0.729 rs6479418 chr9:95064762 G/A cg13798575 chr9:95087839 CENPP;NOL8 -0.48 -7.02 -0.36 1.3e-11 Visceral adipose tissue/subcutaneous adipose tissue ratio; CRC cis rs1552244 0.935 rs35586456 chr3:10116938 A/G cg18598329 chr3:10140678 FANCD2;C3orf24 -0.89 -12.69 -0.57 2.6e-30 Alzheimer's disease; CRC cis rs853679 0.517 rs17774663 chr6:28120898 G/A cg23161317 chr6:28129485 ZNF389 0.53 6.43 0.33 4.52e-10 Depression; CRC cis rs7666738 0.830 rs62318906 chr4:99037110 C/T cg17366294 chr4:99064904 C4orf37 0.44 7.47 0.38 7.18e-13 Colonoscopy-negative controls vs population controls; CRC cis rs921968 0.565 rs6436083 chr2:219639719 C/T cg02176678 chr2:219576539 TTLL4 -0.41 -6.52 -0.34 2.65e-10 Mean corpuscular hemoglobin concentration; CRC cis rs7618915 0.501 rs34754793 chr3:52629177 A/T cg10802521 chr3:52805072 NEK4 -0.58 -9.07 -0.45 1.13e-17 Bipolar disorder; CRC cis rs1707322 0.963 rs10789478 chr1:46350506 C/T cg03146154 chr1:46216737 IPP 0.58 8.14 0.41 8.04e-15 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs9814567 1.000 rs9989967 chr3:134238964 A/C cg06109529 chr3:134205091 CEP63;ANAPC13 -0.8 -11.99 -0.55 9.75e-28 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs427943 0.722 rs8126895 chr21:46609258 A/G cg19498844 chr21:46707878 POFUT2;LOC642852 0.45 5.92 0.31 7.91e-9 Body mass index; CRC cis rs2842992 0.747 rs9365095 chr6:160192928 T/G cg16489826 chr6:160211363 TCP1;MRPL18 0.49 6.27 0.33 1.13e-9 Age-related macular degeneration (geographic atrophy); CRC cis rs2758596 1.000 rs2758617 chr1:156160693 A/G cg25208724 chr1:156163844 SLC25A44 0.73 6.98 0.36 1.64e-11 Paclitaxel disposition in epithelial ovarian cancer; CRC cis rs7615952 0.641 rs12487875 chr3:125787224 C/A cg04553112 chr3:125709451 NA -0.51 -6.0 -0.31 5.13e-9 Blood pressure (smoking interaction); CRC cis rs6952808 0.792 rs34269264 chr7:1948712 C/T cg21782813 chr7:2030301 MAD1L1 0.44 7.41 0.38 1.04e-12 Bipolar disorder and schizophrenia; CRC cis rs9399135 0.967 rs3756799 chr6:135341011 A/G cg22676075 chr6:135203613 NA 0.41 6.26 0.33 1.22e-9 Red blood cell count; CRC cis rs28386778 0.865 rs2727276 chr17:61929709 G/A cg06601766 chr17:61851465 DDX42;CCDC47 0.42 5.77 0.3 1.86e-8 Prudent dietary pattern; CRC cis rs35306767 1.000 rs35306767 chr10:989437 A/T cg26597838 chr10:835615 NA 1.05 12.37 0.56 4.06e-29 Eosinophil percentage of granulocytes; CRC trans rs3794271 0.706 rs9971816 chr12:20826911 C/T cg25606773 chr6:46110412 ENPP4 0.45 6.41 0.33 4.99e-10 Response to TNF-alpha inhibitors in rheumatoid arthritis; CRC trans rs1814175 0.645 rs12364337 chr11:49942580 A/T cg11707556 chr5:10655725 ANKRD33B -0.52 -9.95 -0.48 1.49e-20 Height; CRC cis rs3806843 0.547 rs246048 chr5:140327900 G/A cg19875535 chr5:140030758 IK 0.39 6.02 0.31 4.67e-9 Depressive symptoms (multi-trait analysis); CRC cis rs763121 0.853 rs6001175 chr22:39018334 T/C cg06022373 chr22:39101656 GTPBP1 0.8 13.5 0.6 2.38e-33 Menopause (age at onset); CRC cis rs7811142 0.830 rs7341507 chr7:99951315 A/G cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.7 9.67 0.47 1.24e-19 Platelet count; CRC cis rs7959452 0.535 rs7308481 chr12:69659299 A/G cg20891283 chr12:69753455 YEATS4 0.78 13.01 0.58 1.65e-31 Blood protein levels; CRC cis rs6502050 0.835 rs8066284 chr17:80127825 C/T cg13198984 chr17:80129470 CCDC57 0.46 8.13 0.41 9e-15 Life satisfaction; CRC cis rs66573146 0.572 rs73199995 chr4:6955801 G/C cg00086871 chr4:6988644 TBC1D14 0.86 8.33 0.42 2.29e-15 Granulocyte percentage of myeloid white cells; CRC cis rs2243480 1.000 rs313809 chr7:65499983 G/A cg12463550 chr7:65579703 CRCP 0.71 6.41 0.33 4.97e-10 Diabetic kidney disease; CRC trans rs58688157 0.705 rs12419618 chr11:611531 G/A cg19188899 chr13:112838565 NA -0.43 -6.77 -0.35 5.75e-11 Systemic lupus erythematosus; CRC cis rs477692 0.569 rs10764885 chr10:131310207 G/A cg05714579 chr10:131428358 MGMT 0.53 7.65 0.39 2.28e-13 Response to temozolomide; CRC cis rs270601 0.721 rs270621 chr5:131605821 C/A cg02033258 chr5:131593261 PDLIM4 0.48 8.32 0.42 2.31e-15 Acylcarnitine levels; CRC cis rs6942756 0.715 rs6467242 chr7:129001173 T/A cg02491457 chr7:128862824 NA -0.61 -8.3 -0.42 2.77e-15 White matter hyperintensity burden; CRC cis rs2346177 0.542 rs6757564 chr2:46702619 G/C cg26688816 chr2:46740690 ATP6V1E2 -0.58 -9.22 -0.45 3.72e-18 HDL cholesterol; CRC cis rs6500395 0.962 rs17826468 chr16:48568271 A/G cg04672837 chr16:48644449 N4BP1 0.41 5.9 0.31 9.11e-9 Response to tocilizumab in rheumatoid arthritis; CRC cis rs2243480 1.000 rs56985706 chr7:65394562 C/T cg18252515 chr7:66147081 NA -1.08 -12.66 -0.57 3.44e-30 Diabetic kidney disease; CRC cis rs7727544 0.836 rs10463892 chr5:131598705 T/C cg11843238 chr5:131593191 PDLIM4 0.34 6.62 0.34 1.5e-10 Blood metabolite levels; CRC cis rs10927875 0.501 rs9660676 chr1:16279041 C/T cg21385522 chr1:16154831 NA -0.83 -9.71 -0.47 9.23e-20 Dilated cardiomyopathy; CRC cis rs2730245 1.000 rs2252502 chr7:158738634 G/C cg24397884 chr7:158709396 WDR60 -0.96 -16.26 -0.67 4.64e-44 Height; CRC trans rs7615952 0.546 rs16836896 chr3:125311262 A/T cg02560186 chr11:3602584 NA -0.55 -6.64 -0.34 1.29e-10 Blood pressure (smoking interaction); CRC cis rs9660180 0.783 rs1107910 chr1:1692321 C/T cg13866156 chr1:1669148 SLC35E2 -0.5 -7.67 -0.39 1.92e-13 Body mass index; CRC cis rs10450586 0.863 rs7119628 chr11:27302716 G/A cg10370305 chr11:27303972 NA 0.37 6.06 0.32 3.69e-9 Total body bone mineral density; CRC cis rs863345 0.604 rs949397 chr1:158461951 G/T cg12129480 chr1:158549410 OR10X1 -0.29 -6.04 -0.32 4.2e-9 Pneumococcal bacteremia; CRC cis rs2455601 0.882 rs11042105 chr11:8894510 G/C cg21881798 chr11:8931708 C11orf17;ST5 -0.54 -6.08 -0.32 3.41e-9 Schizophrenia; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg25009629 chr6:41748519 FRS3;PRICKLE4 0.41 6.81 0.35 4.57e-11 Liver disease severity in Alagille syndrome; CRC cis rs9303280 0.806 rs2305480 chr17:38062196 G/A cg11212589 chr17:38028394 ZPBP2 0.42 7.7 0.39 1.59e-13 Self-reported allergy; CRC cis rs1046896 0.731 rs9906115 chr17:80791469 G/A cg17346650 chr17:80929145 B3GNTL1 0.47 6.73 0.35 7.74e-11 Glycated hemoglobin levels; CRC cis rs933688 0.941 rs2887007 chr5:90740531 A/T cg02339078 chr5:90679543 LOC100129716;ARRDC3 0.93 15.43 0.65 8.56e-41 Smoking behavior; CRC cis rs9381040 0.655 rs9394756 chr6:41016183 A/G cg04346459 chr6:41068666 NFYA;LOC221442 -0.43 -6.35 -0.33 7.24e-10 Alzheimer's disease (late onset); CRC cis rs1707322 0.716 rs28375469 chr1:46195375 T/C cg06784218 chr1:46089804 CCDC17 0.65 12.05 0.55 5.8e-28 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs1707322 0.964 rs785516 chr1:46564758 T/G cg03146154 chr1:46216737 IPP -0.59 -8.06 -0.41 1.44e-14 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC trans rs35110281 0.776 rs229357 chr21:44982717 T/C cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.54 9.26 0.45 2.62e-18 Mean corpuscular volume; CRC cis rs12681288 0.823 rs4735974 chr8:1000218 T/G cg08648136 chr8:956695 NA 0.3 6.03 0.32 4.3e-9 Schizophrenia; CRC cis rs12681287 0.640 rs28561640 chr8:87425638 G/A cg27223183 chr8:87520930 FAM82B 0.51 6.94 0.36 2.15e-11 Caudate activity during reward; CRC cis rs1223397 0.651 rs2439541 chr6:13310567 T/C cg07912922 chr6:13274314 PHACTR1 0.39 6.07 0.32 3.52e-9 Blood pressure; CRC cis rs853679 0.517 rs36078605 chr6:28078032 A/C cg02631126 chr6:28058918 ZSCAN12L1 0.28 5.69 0.3 2.82e-8 Depression; CRC cis rs2991971 0.967 rs12133294 chr1:45988764 C/T cg24296786 chr1:45957014 TESK2 0.57 8.45 0.42 9.31e-16 High light scatter reticulocyte count; CRC cis rs4638749 0.677 rs10174695 chr2:108842164 G/A cg25838818 chr2:108905173 SULT1C2 -0.33 -5.61 -0.3 4.35e-8 Blood pressure; CRC cis rs924607 0.900 rs1697950 chr5:616890 G/A cg24163568 chr5:669837 TPPP -0.43 -6.91 -0.36 2.48e-11 Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia; CRC cis rs9487051 0.676 rs1608041 chr6:109595903 G/A cg01475377 chr6:109611718 NA -0.37 -6.58 -0.34 1.85e-10 Reticulocyte fraction of red cells; CRC cis rs938554 0.876 rs737267 chr4:9934744 G/T cg00071950 chr4:10020882 SLC2A9 -0.4 -5.63 -0.3 3.94e-8 Blood metabolite levels; CRC cis rs1552244 1.000 rs28684871 chr3:10072635 C/A cg00166722 chr3:10149974 C3orf24 0.63 8.38 0.42 1.55e-15 Alzheimer's disease; CRC cis rs10256972 0.552 rs7805591 chr7:1210745 A/G cg22907277 chr7:1156413 C7orf50 0.65 9.81 0.48 4.36e-20 Longevity;Endometriosis; CRC cis rs6570726 0.516 rs9322025 chr6:145729196 C/T cg23711669 chr6:146136114 FBXO30 0.45 7.23 0.37 3.5e-12 Lobe attachment (rater-scored or self-reported); CRC cis rs972578 0.806 rs4822225 chr22:43310652 G/T cg01576275 chr22:43409880 NA -0.39 -6.0 -0.31 5.21e-9 Mean platelet volume; CRC trans rs9443645 0.870 rs9350799 chr6:79723651 C/A cg06129210 chr16:17565129 XYLT1 -0.34 -6.0 -0.31 5.24e-9 Intelligence (multi-trait analysis); CRC cis rs2070488 0.775 rs1073505 chr3:38566722 T/C cg01465620 chr3:38496096 LOC100128640;ACVR2B -0.75 -12.46 -0.57 1.87e-29 Electrocardiographic conduction measures; CRC cis rs6942756 1.000 rs7778277 chr7:128978805 C/T cg02491457 chr7:128862824 NA -0.76 -10.25 -0.49 1.46e-21 White matter hyperintensity burden; CRC cis rs873946 0.517 rs7071784 chr10:134559980 T/C cg06453172 chr10:134556979 INPP5A -0.58 -7.75 -0.39 1.13e-13 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CRC cis rs78456975 1.000 rs13413356 chr2:1553849 G/T cg12573674 chr2:1569213 NA -0.75 -7.87 -0.4 5.22e-14 Placebo response in major depressive disorder (% change in symptom score); CRC cis rs796364 0.951 rs7565005 chr2:201013277 A/G cg23649088 chr2:200775458 C2orf69 -0.58 -6.36 -0.33 6.94e-10 Schizophrenia; CRC cis rs7074356 0.569 rs1832683 chr10:82032331 C/T cg05935833 chr10:81318306 SFTPA2 -0.41 -5.89 -0.31 9.46e-9 Borderline personality disorder; CRC cis rs10256972 0.616 rs6957733 chr7:1106327 T/G cg03188948 chr7:1209495 NA 0.4 6.02 0.32 4.56e-9 Longevity;Endometriosis; CRC cis rs4594175 0.926 rs10135534 chr14:51617970 C/A cg23942311 chr14:51606299 NA 0.66 11.17 0.52 8.84e-25 Cancer; CRC cis rs11971779 0.680 rs10085902 chr7:139109105 G/C cg23387468 chr7:139079360 LUC7L2 0.41 7.05 0.36 1.04e-11 Diisocyanate-induced asthma; CRC cis rs7772486 0.875 rs10457793 chr6:146415403 A/G cg13319975 chr6:146136371 FBXO30 -0.4 -6.17 -0.32 2.05e-9 Lobe attachment (rater-scored or self-reported); CRC trans rs7647973 0.626 rs9829155 chr3:49817450 T/C cg21665057 chr3:196295764 WDR53;FBXO45 0.61 6.73 0.35 7.76e-11 Menarche (age at onset); CRC cis rs6121246 0.559 rs6058352 chr20:30269179 T/C cg13852791 chr20:30311386 BCL2L1 0.74 14.62 0.63 1.24e-37 Mean corpuscular hemoglobin; CRC trans rs11098499 0.604 rs2389887 chr4:120570644 T/C cg25214090 chr10:38739885 LOC399744 0.58 8.59 0.43 3.67e-16 Corneal astigmatism; CRC cis rs7811142 1.000 rs11766752 chr7:100073292 A/G cg00814883 chr7:100076585 TSC22D4 -0.74 -9.58 -0.47 2.55e-19 Platelet count; CRC cis rs2243480 1.000 rs313831 chr7:65551226 C/T cg25985355 chr7:65971099 NA -0.48 -5.67 -0.3 3.15e-8 Diabetic kidney disease; CRC cis rs12477438 0.798 rs6716913 chr2:99580641 T/C cg14399236 chr2:99771627 LIPT1;TSGA10 -0.7 -9.74 -0.47 7.45e-20 Chronic sinus infection; CRC cis rs12142240 0.698 rs61519400 chr1:46855298 A/G cg00530320 chr1:46809349 NSUN4 0.58 7.9 0.4 4.24e-14 Menopause (age at onset); CRC cis rs7517126 1.000 rs2336536 chr1:196839514 T/C cg13682187 chr1:196946512 CFHR5 -0.36 -5.92 -0.31 7.89e-9 Blood protein levels; CRC cis rs8072100 0.967 rs11871606 chr17:45732774 G/T cg08085267 chr17:45401833 C17orf57 0.61 9.94 0.48 1.61e-20 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs40363 0.729 rs6501176 chr16:3522197 A/G cg22508957 chr16:3507546 NAT15 -0.72 -9.41 -0.46 9.19e-19 Tuberculosis; CRC cis rs72772090 0.539 rs72775810 chr5:96185307 A/T cg17330273 chr5:96107758 CAST;ERAP1 -0.61 -5.71 -0.3 2.48e-8 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs7811142 1.000 rs67239991 chr7:100046504 A/G cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.16 17.98 0.7 7.57e-51 Platelet count; CRC cis rs2836950 0.501 rs11088470 chr21:40689162 A/G cg11890956 chr21:40555474 PSMG1 -0.61 -8.99 -0.44 1.95e-17 Menarche (age at onset); CRC cis rs1448094 0.549 rs12308898 chr12:86233678 G/A cg00310523 chr12:86230176 RASSF9 0.35 5.8 0.3 1.52e-8 Major depressive disorder; CRC cis rs4713118 0.662 rs469228 chr6:27970704 A/G cg12172441 chr6:28176163 NA 0.54 7.43 0.38 9.55e-13 Parkinson's disease; CRC cis rs10504229 1.000 rs66796009 chr8:58174529 G/A cg02290350 chr8:58132656 NA -0.42 -6.0 -0.31 5.25e-9 Developmental language disorder (linguistic errors); CRC cis rs9837602 0.872 rs34996634 chr3:99738219 T/A cg07805332 chr3:99536008 MIR548G;C3orf26 -0.49 -6.1 -0.32 3.05e-9 Breast cancer; CRC cis rs7772486 0.536 rs9373467 chr6:145955605 C/T cg13319975 chr6:146136371 FBXO30 -0.61 -8.69 -0.43 1.74e-16 Lobe attachment (rater-scored or self-reported); CRC cis rs17001868 0.568 rs760700 chr22:40800071 C/T cg07138101 chr22:40742427 ADSL -0.49 -6.85 -0.35 3.75e-11 Mammographic density (dense area); CRC trans rs9858542 0.953 rs7633271 chr3:49555963 T/C cg21659725 chr3:3221576 CRBN -0.66 -9.09 -0.45 9.55e-18 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs1707322 0.964 rs1707339 chr1:46513179 A/G cg06784218 chr1:46089804 CCDC17 -0.55 -9.74 -0.47 7.37e-20 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs7103648 0.669 rs7114011 chr11:47811309 A/C cg20307385 chr11:47447363 PSMC3 0.75 10.24 0.49 1.55e-21 Diastolic blood pressure;Systolic blood pressure; CRC cis rs35146811 0.735 rs1727133 chr7:99812870 C/T cg00553149 chr7:99775558 STAG3;GPC2 -0.24 -5.61 -0.3 4.38e-8 Coronary artery disease; CRC cis rs7811142 1.000 rs11766752 chr7:100073292 A/G cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.75 10.37 0.5 5.39e-22 Platelet count; CRC cis rs1401999 1.000 rs6805913 chr3:183662924 T/G cg01324343 chr3:183735012 ABCC5 0.81 14.73 0.63 4.44e-38 Anterior chamber depth; CRC cis rs7666738 0.791 rs10017624 chr4:98984009 G/T cg05340658 chr4:99064831 C4orf37 0.6 9.41 0.46 8.57e-19 Colonoscopy-negative controls vs population controls; CRC cis rs11190604 1.000 rs2489050 chr10:102350898 T/A cg16342193 chr10:102329863 NA -0.38 -5.97 -0.31 6.03e-9 Palmitoleic acid (16:1n-7) levels; CRC trans rs10507419 1.000 rs17753659 chr13:35187616 T/G cg00944431 chr1:10896004 NA 0.42 6.03 0.32 4.37e-9 Immunoglobulin light chain (AL) amyloidosis (serum Ig lambda profile);Immunoglobulin light chain (AL) amyloidosis (serum IgG profile); CRC cis rs3858526 1.000 rs11039787 chr11:5965611 C/T cg02574844 chr11:5959923 NA -0.47 -6.61 -0.34 1.56e-10 DNA methylation (variation); CRC cis rs8060686 0.516 rs13339471 chr16:68253008 A/G cg26727032 chr16:67993705 SLC12A4 -0.63 -9.37 -0.46 1.18e-18 HDL cholesterol;Metabolic syndrome; CRC cis rs9311676 0.632 rs34086582 chr3:58419944 C/T cg06643156 chr3:58380774 PXK 0.42 6.43 0.33 4.39e-10 Systemic lupus erythematosus; CRC cis rs9914988 0.943 rs12951232 chr17:27132638 G/C cg16670446 chr17:27188758 MIR451;MIR144 0.55 8.52 0.43 5.75e-16 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs2949837 0.581 rs2949838 chr7:45993924 T/C cg10677697 chr7:45961126 IGFBP3 0.36 6.34 0.33 7.54e-10 Sitting height ratio; CRC cis rs6694672 0.681 rs865071 chr1:197017976 G/A cg13682187 chr1:196946512 CFHR5 0.48 7.43 0.38 9.48e-13 Asthma; CRC cis rs12024301 0.557 rs10911411 chr1:183661522 G/A cg11505048 chr1:183622726 RGL1;APOBEC4 0.71 6.24 0.33 1.33e-9 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs2249694 1.000 rs2480259 chr10:135352076 A/G cg20169779 chr10:135381914 SYCE1 0.54 8.71 0.43 1.45e-16 Obesity-related traits; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg16294016 chr4:190862268 FRG1 0.42 6.92 0.36 2.44e-11 Liver disease severity in Alagille syndrome; CRC cis rs875971 0.545 rs316324 chr7:65610614 A/G cg11764359 chr7:65958608 NA -0.48 -6.06 -0.32 3.67e-9 Aortic root size; CRC cis rs5769707 0.632 rs1476037 chr22:49991377 G/A cg20744362 chr22:50050164 C22orf34 0.31 5.72 0.3 2.37e-8 Monocyte count;Monocyte percentage of white cells; CRC cis rs2228479 0.850 rs2238532 chr16:89863672 T/C cg06558623 chr16:89946397 TCF25 1.16 11.31 0.53 2.79e-25 Skin colour saturation; CRC cis rs11785400 0.793 rs2976400 chr8:143743611 G/A cg10596483 chr8:143751796 JRK 0.44 5.87 0.31 1.09e-8 Schizophrenia; CRC cis rs7124681 0.584 rs4752792 chr11:47815702 G/A cg20307385 chr11:47447363 PSMC3 -0.46 -6.74 -0.35 7.09e-11 Body mass index (joint analysis main effects and physical activity interaction);Body mass index;Body mass index in physically active individuals; CRC cis rs6502050 0.835 rs9904520 chr17:80100117 T/C cg02741985 chr17:80059408 CCDC57 0.43 7.15 0.37 5.66e-12 Life satisfaction; CRC cis rs2797160 0.904 rs1418637 chr6:125992553 A/G cg05901451 chr6:126070800 HEY2 -0.37 -5.64 -0.3 3.63e-8 Endometrial cancer; CRC cis rs9303542 0.559 rs12603976 chr17:46617163 C/A cg04904318 chr17:46607828 HOXB1 -0.52 -6.11 -0.32 2.82e-9 Ovarian cancer;Epithelial ovarian cancer; CRC cis rs77633900 0.772 rs284884 chr15:76828289 A/G cg21673338 chr15:77095150 SCAPER -0.71 -6.2 -0.32 1.71e-9 Non-glioblastoma glioma;Glioma; CRC cis rs3540 0.574 rs2526000 chr15:90962626 C/T cg22089800 chr15:90895588 ZNF774 0.58 9.48 0.46 5.35e-19 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; CRC cis rs7584330 0.554 rs729389 chr2:238425118 G/A cg14458575 chr2:238380390 NA 0.45 6.46 0.34 3.83e-10 Prostate cancer; CRC cis rs4666002 0.956 rs13020949 chr2:27836605 C/T cg27432699 chr2:27873401 GPN1 0.48 6.18 0.32 1.89e-9 Phospholipid levels (plasma); CRC cis rs2066819 1.000 rs77120931 chr12:56646213 A/C cg26714650 chr12:56694279 CS -1.38 -11.34 -0.53 2.14e-25 Psoriasis vulgaris; CRC cis rs10504229 1.000 rs66886949 chr8:58187613 A/G cg22535103 chr8:58192502 C8orf71 -0.82 -12.27 -0.56 9.63e-29 Developmental language disorder (linguistic errors); CRC cis rs6743376 0.556 rs2515397 chr2:113819258 T/C cg24553058 chr2:113831203 IL1F10 0.43 6.96 0.36 1.81e-11 Inflammatory biomarkers; CRC cis rs9435341 0.965 rs1335053 chr1:107622823 C/T cg14828511 chr1:107599125 PRMT6 -0.54 -7.49 -0.38 6.29e-13 Facial morphology (factor 21, depth of nasal alae); CRC cis rs9826463 0.527 rs56088529 chr3:142146369 A/G cg20824294 chr3:142316082 PLS1 0.35 5.64 0.3 3.61e-8 QRS duration in Tripanosoma cruzi seropositivity; CRC cis rs7246760 1.000 rs67359088 chr19:9863668 C/T cg16876255 chr19:9731953 ZNF561 0.68 5.71 0.3 2.5e-8 Pursuit maintenance gain; CRC trans rs57221529 0.766 rs4245972 chr5:578572 A/G cg25482853 chr8:67687455 SGK3 1.25 14.99 0.64 4.45e-39 Lung disease severity in cystic fibrosis; CRC cis rs2933343 0.621 rs6764682 chr3:128568383 G/A cg11901034 chr3:128598214 ACAD9 0.52 7.56 0.38 4.1e-13 IgG glycosylation; CRC cis rs2836974 0.931 rs13047663 chr21:40708818 C/T cg07074390 chr21:40555500 PSMG1 -0.45 -5.99 -0.31 5.57e-9 Cognitive function; CRC cis rs9858542 0.953 rs9858280 chr3:49597737 T/C cg07274523 chr3:49395745 GPX1 0.47 6.41 0.33 5.12e-10 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC trans rs587242 0.955 rs4949996 chr1:96965124 A/T cg10631902 chr5:14652156 NA 0.4 6.15 0.32 2.23e-9 Body mass index (joint analysis main effects and physical activity interaction);Body mass index in physically inactive individuals;Body mass index; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg16587860 chr12:123459310 OGFOD2;ABCB9 0.43 6.12 0.32 2.64e-9 Response to antipsychotic treatment; CRC cis rs6977660 0.652 rs10486362 chr7:19755224 A/G cg07541023 chr7:19748670 TWISTNB -1.13 -10.47 -0.5 2.57e-22 Thyroid stimulating hormone; CRC cis rs7615952 0.641 rs66520539 chr3:125780374 G/A cg04553112 chr3:125709451 NA -0.51 -5.89 -0.31 9.55e-9 Blood pressure (smoking interaction); CRC cis rs13108904 0.967 rs62293658 chr4:1276416 T/C cg16405210 chr4:1374714 KIAA1530 0.45 6.68 0.35 1.01e-10 Obesity-related traits; CRC cis rs9911578 0.900 rs717828 chr17:56535932 A/G cg05425664 chr17:57184151 TRIM37 -0.52 -8.13 -0.41 8.73e-15 Intelligence (multi-trait analysis); CRC cis rs896854 0.631 rs10097617 chr8:95961626 T/C cg09323728 chr8:95962352 TP53INP1 -0.44 -7.3 -0.37 2.12e-12 Type 2 diabetes; CRC cis rs12541335 0.639 rs7003478 chr8:22201123 A/G cg14487702 chr8:22132665 PIWIL2 0.38 5.68 0.3 3.04e-8 Hypertriglyceridemia; CRC cis rs17270561 0.666 rs4712971 chr6:25771900 T/C cg17691542 chr6:26056736 HIST1H1C 0.67 8.29 0.42 2.95e-15 Iron status biomarkers; CRC cis rs763121 0.853 rs6001182 chr22:39047443 A/G cg06544989 chr22:39130855 UNC84B 0.44 6.84 0.35 3.76e-11 Menopause (age at onset); CRC cis rs9311474 0.581 rs13621 chr3:52558133 T/C cg11645453 chr3:52864694 ITIH4 0.34 6.27 0.33 1.12e-9 Electroencephalogram traits; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg14266050 chr4:2845671 ADD1 -0.41 -6.05 -0.32 3.95e-9 Myopia (pathological); CRC cis rs2836974 0.829 rs8128191 chr21:40527311 A/G cg11890956 chr21:40555474 PSMG1 1.1 21.14 0.76 3.07e-63 Cognitive function; CRC cis rs7312774 0.748 rs7966019 chr12:107297502 G/T cg16260113 chr12:107380972 MTERFD3 0.78 7.73 0.39 1.29e-13 Severe influenza A (H1N1) infection; CRC cis rs11971779 0.680 rs6960876 chr7:139112176 C/T cg07862535 chr7:139043722 LUC7L2 -0.57 -7.42 -0.38 9.83e-13 Diisocyanate-induced asthma; CRC cis rs501120 0.584 rs61857484 chr10:44719215 C/A cg09554077 chr10:44749378 NA 0.65 7.29 0.37 2.37e-12 Coronary artery disease;Coronary heart disease; CRC cis rs2281845 0.826 rs4915214 chr1:201076290 T/A cg08885800 chr1:201084119 NA 0.42 7.43 0.38 9.59e-13 Permanent tooth development; CRC cis rs12188164 0.543 rs2434695 chr5:464177 C/G cg14122633 chr5:456516 EXOC3 -0.39 -6.89 -0.36 2.78e-11 Cystic fibrosis severity; CRC cis rs7680126 0.500 rs11735668 chr4:10148655 C/G cg00071950 chr4:10020882 SLC2A9 -0.48 -5.9 -0.31 8.88e-9 Urate levels in lean individuals;Urate levels in overweight individuals;Urate levels in obese individuals; CRC cis rs3857536 0.813 rs9453639 chr6:66933538 C/T cg07460842 chr6:66804631 NA -0.42 -5.7 -0.3 2.64e-8 Blood trace element (Cu levels); CRC cis rs798554 1.000 rs798544 chr7:2763102 A/G cg19717773 chr7:2847554 GNA12 0.43 6.29 0.33 1.02e-9 Height; CRC cis rs7044106 0.762 rs7357638 chr9:123389204 G/A cg09586646 chr9:123605570 PSMD5;LOC253039 0.62 8.78 0.44 8.97e-17 Hip circumference adjusted for BMI; CRC cis rs17376456 0.825 rs74825443 chr5:93254973 T/C cg09848695 chr5:92956644 FAM172A;MIR2277 0.7 6.21 0.32 1.58e-9 Diabetic retinopathy; CRC cis rs13108904 0.870 rs4974578 chr4:1266072 A/G cg19318889 chr4:1322082 MAEA 0.41 5.78 0.3 1.71e-8 Obesity-related traits; CRC cis rs11997175 0.574 rs4446694 chr8:33654978 A/G ch.8.33884649F chr8:33765107 NA 0.48 7.79 0.39 8.75e-14 Body mass index; CRC cis rs7107174 0.792 rs2888465 chr11:77945807 T/C cg02023728 chr11:77925099 USP35 0.57 8.71 0.43 1.52e-16 Testicular germ cell tumor; CRC cis rs6952808 0.578 rs6949478 chr7:1841342 A/G cg21782813 chr7:2030301 MAD1L1 -0.37 -5.73 -0.3 2.28e-8 Bipolar disorder and schizophrenia; CRC cis rs6502050 0.731 rs9892653 chr17:80100191 G/T cg02741985 chr17:80059408 CCDC57 0.43 7.15 0.37 5.66e-12 Life satisfaction; CRC cis rs79057730 0.599 rs35928068 chr7:805363 G/C cg11064039 chr7:766100 PRKAR1B;HEATR2 0.69 6.73 0.35 7.62e-11 Initial pursuit acceleration; CRC cis rs5769707 0.967 rs2051626 chr22:50008973 G/A cg05373962 chr22:49881684 NA -0.39 -7.47 -0.38 7.34e-13 Monocyte count;Monocyte percentage of white cells; CRC trans rs853679 0.546 rs200977 chr6:27854301 T/C cg12315302 chr6:26189340 HIST1H4D 0.71 6.01 0.31 5.02e-9 Depression; CRC cis rs1129187 0.837 rs3763236 chr6:42902508 C/T cg02353165 chr6:42928485 GNMT -0.63 -10.28 -0.49 1.12e-21 Alzheimer's disease in APOE e4+ carriers; CRC trans rs8002861 0.905 rs12874535 chr13:44433565 A/G cg17145862 chr1:211918768 LPGAT1 -0.68 -12.46 -0.57 1.86e-29 Leprosy; CRC cis rs10208940 0.764 rs6546420 chr2:68799454 G/A cg12452813 chr2:68675892 NA 0.47 5.93 0.31 7.79e-9 Urate levels in lean individuals; CRC cis rs2739330 0.796 rs2154594 chr22:24254055 A/G cg04234412 chr22:24373322 LOC391322 0.7 11.35 0.53 1.96e-25 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs9300255 0.699 rs11057204 chr12:123725827 T/C cg00376283 chr12:123451042 ABCB9 0.54 7.05 0.36 1.08e-11 Neutrophil percentage of white cells; CRC cis rs10504229 0.728 rs72650860 chr8:58153111 A/G cg21724239 chr8:58056113 NA 0.62 8.38 0.42 1.51e-15 Developmental language disorder (linguistic errors); CRC cis rs7208859 0.623 rs9899268 chr17:29150255 T/C cg19761014 chr17:28927070 LRRC37B2 0.58 5.85 0.31 1.16e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs7680126 0.633 rs11730631 chr4:10292968 C/T cg11266682 chr4:10021025 SLC2A9 0.42 6.49 0.34 3.22e-10 Urate levels in lean individuals;Urate levels in overweight individuals;Urate levels in obese individuals; CRC cis rs9311676 0.632 rs6774357 chr3:58361530 A/C cg06643156 chr3:58380774 PXK 0.43 6.73 0.35 7.6e-11 Systemic lupus erythematosus; CRC cis rs62064224 0.512 rs9912766 chr17:30712780 A/G cg25809561 chr17:30822961 MYO1D 0.51 9.16 0.45 5.77e-18 Schizophrenia; CRC trans rs4733601 0.659 rs12156376 chr8:129253823 A/G cg01372202 chr19:50097851 PRR12 0.38 5.97 0.31 6.15e-9 Diffuse large B cell lymphoma; CRC trans rs643955 0.609 rs13259465 chr8:9982953 C/G cg06636001 chr8:8085503 FLJ10661 -0.43 -6.05 -0.32 3.93e-9 Systemic lupus erythematosus; CRC cis rs7927771 0.800 rs35996350 chr11:47389223 A/G cg05585544 chr11:47624801 NA -0.5 -8.79 -0.44 8.59e-17 Subjective well-being; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg23024448 chr19:51222118 NA 0.37 6.23 0.32 1.42e-9 Liver disease severity in Alagille syndrome; CRC cis rs965469 1.000 rs2092990 chr20:3346338 C/T cg25506879 chr20:3388711 C20orf194 -0.4 -5.77 -0.3 1.81e-8 IFN-related cytopenia; CRC cis rs4853012 0.539 rs9789534 chr2:74362990 A/T cg05890377 chr2:74357713 NA 0.54 9.09 0.45 9.44e-18 Gestational age at birth (maternal effect); CRC cis rs875971 1.000 rs11971949 chr7:65626014 A/G cg11764359 chr7:65958608 NA -0.62 -9.97 -0.48 1.21e-20 Aortic root size; CRC cis rs7945705 0.870 rs4929922 chr11:8975776 A/G cg14711859 chr11:8959438 ASCL3 0.46 7.07 0.36 9.17e-12 Hemoglobin concentration; CRC cis rs10870270 0.913 rs4880326 chr10:133745547 C/A cg08754478 chr10:133766260 PPP2R2D -0.68 -9.75 -0.47 6.55e-20 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; CRC cis rs17767392 0.836 rs2332640 chr14:72044547 C/T cg13720639 chr14:72061746 SIPA1L1 0.57 7.06 0.36 1.01e-11 Mitral valve prolapse; CRC cis rs7618501 0.633 rs2526751 chr3:50064867 T/C cg05623727 chr3:50126028 RBM5 -0.45 -7.5 -0.38 5.92e-13 Intelligence (multi-trait analysis); CRC cis rs7493 0.950 rs56265549 chr7:95047155 G/A cg04155289 chr7:94953770 PON1 -0.59 -7.48 -0.38 6.83e-13 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs6484504 0.532 rs1475558 chr11:31263428 A/G cg14844989 chr11:31128820 NA -0.34 -5.9 -0.31 8.82e-9 Red blood cell count; CRC cis rs932287 0.858 rs7109896 chr11:9054522 A/G cg21881798 chr11:8931708 C11orf17;ST5 0.45 6.61 0.34 1.52e-10 Colonoscopy-negative controls vs population controls; CRC trans rs2727020 0.729 rs4980439 chr11:49342246 G/C cg15704280 chr7:45808275 SEPT13 -0.87 -15.89 -0.66 1.31e-42 Coronary artery disease; CRC trans rs2243480 1.000 rs431318 chr7:65511597 G/A cg10756647 chr7:56101905 PSPH 0.75 7.66 0.39 2.05e-13 Diabetic kidney disease; CRC trans rs3960554 0.808 rs4728587 chr7:75803132 C/T cg19862616 chr7:65841803 NCRNA00174 0.74 8.53 0.43 5.62e-16 Eotaxin levels; CRC cis rs7811142 0.830 rs7792959 chr7:99972403 C/T cg00814883 chr7:100076585 TSC22D4 -0.68 -8.64 -0.43 2.57e-16 Platelet count; CRC cis rs9326248 0.954 rs10790177 chr11:117048417 A/G cg10398005 chr11:117014888 PAFAH1B2 -0.4 -5.74 -0.3 2.2e-8 Blood protein levels; CRC cis rs79387448 0.638 rs78123896 chr2:103075417 T/C cg09003973 chr2:102972529 NA 0.73 7.66 0.39 2.12e-13 Gut microbiota (bacterial taxa); CRC cis rs6921919 0.583 rs16894108 chr6:28401790 A/G cg21251018 chr6:28226885 NKAPL 0.4 6.1 0.32 2.93e-9 Autism spectrum disorder or schizophrenia; CRC cis rs185694 0.947 rs595451 chr13:30896848 T/C cg07600127 chr13:30881527 KATNAL1 -0.56 -6.05 -0.32 3.94e-9 Antineutrophil cytoplasmic antibody-associated vasculitis; CRC cis rs12230513 0.732 rs4130004 chr12:55860773 G/T cg19537932 chr12:55886519 OR6C68 -0.73 -9.4 -0.46 9.2e-19 Contrast sensitivity; CRC cis rs7089973 0.604 rs61596353 chr10:116597763 T/C cg23260525 chr10:116636907 FAM160B1 0.35 8.12 0.41 9.56e-15 Bipolar disorder or attention deficit hyperactivity disorder; CRC trans rs11039798 1.000 rs12280020 chr11:48618844 G/C cg15704280 chr7:45808275 SEPT13 0.61 6.02 0.31 4.62e-9 Axial length; CRC cis rs6502050 0.835 rs7503225 chr17:80099639 C/A cg11859384 chr17:80120422 CCDC57 -0.37 -5.85 -0.31 1.16e-8 Life satisfaction; CRC cis rs1559088 0.545 rs7257431 chr19:33566924 A/G cg27124370 chr19:33622961 WDR88 0.49 7.21 0.37 3.79e-12 Bone ultrasound measurement (broadband ultrasound attenuation); CRC cis rs62244186 0.714 rs2293600 chr3:44599103 G/T cg10263370 chr3:44754102 ZNF502 0.37 6.22 0.32 1.53e-9 Depressive symptoms; CRC cis rs10540 0.908 rs35608427 chr11:498976 T/C cg03934478 chr11:495069 RNH1 0.67 7.53 0.38 5.04e-13 Body mass index; CRC trans rs1005277 0.579 rs2474586 chr10:38418882 T/C cg23533926 chr12:111358616 MYL2 -0.53 -7.96 -0.4 2.83e-14 Extrinsic epigenetic age acceleration; CRC cis rs11645898 0.935 rs4788611 chr16:72175256 A/G cg14768367 chr16:72042858 DHODH -0.6 -6.68 -0.35 1.04e-10 Blood protein levels; CRC cis rs9905704 0.647 rs2108435 chr17:57102133 T/C cg12560992 chr17:57184187 TRIM37 -0.67 -10.45 -0.5 2.96e-22 Testicular germ cell tumor; CRC cis rs4812048 0.649 rs6070702 chr20:57621562 G/C cg14073986 chr20:57617431 SLMO2 0.56 5.93 0.31 7.64e-9 Mean platelet volume; CRC cis rs9733 0.596 rs12077833 chr1:150674333 C/T cg18016565 chr1:150552671 MCL1 0.46 6.68 0.35 1.04e-10 Tonsillectomy; CRC cis rs8016982 1.000 rs8016982 chr14:81707057 C/T cg01989461 chr14:81687754 GTF2A1 0.41 5.73 0.3 2.22e-8 Schizophrenia; CRC cis rs1552244 0.882 rs61429272 chr3:10037320 G/C cg16606324 chr3:10149918 C3orf24 0.62 8.08 0.41 1.25e-14 Alzheimer's disease; CRC cis rs6952808 0.792 rs34269264 chr7:1948712 C/T cg20295408 chr7:1910781 MAD1L1 -0.43 -5.93 -0.31 7.62e-9 Bipolar disorder and schizophrenia; CRC cis rs802075 0.764 rs13202956 chr6:49652613 C/T cg20364632 chr6:49636226 NA -0.41 -6.86 -0.35 3.51e-11 Bone mineral density (hip) and age at menarche; CRC cis rs9486715 0.964 rs6921480 chr6:97066329 C/G cg06623918 chr6:96969491 KIAA0776 -0.9 -14.88 -0.63 1.14e-38 Headache; CRC cis rs9391253 0.534 rs1933802 chr6:105365891 C/G cg02098413 chr6:105308735 HACE1 0.31 5.65 0.3 3.44e-8 Height;Age at voice drop;Puberty onset (breast development); CRC cis rs11719291 0.915 rs1048940 chr3:48725707 C/T cg01304814 chr3:48885189 PRKAR2A 0.87 6.49 0.34 3.07e-10 Cognitive function; CRC cis rs2997447 0.846 rs61775419 chr1:26395539 C/T cg24519413 chr1:26490540 NA 0.46 5.66 0.3 3.22e-8 QRS complex (12-leadsum); CRC cis rs185694 0.779 rs628483 chr13:30895462 C/T cg07600127 chr13:30881527 KATNAL1 -0.51 -5.8 -0.3 1.52e-8 Antineutrophil cytoplasmic antibody-associated vasculitis; CRC cis rs6912958 0.712 rs7746465 chr6:88348996 T/G cg08069147 chr6:88032118 GJB7;C6orf162 -0.56 -8.42 -0.42 1.16e-15 Monocyte percentage of white cells; CRC cis rs853679 0.517 rs35227624 chr6:28132726 A/G cg02631126 chr6:28058918 ZSCAN12L1 0.29 5.91 0.31 8.38e-9 Depression; CRC cis rs344364 0.511 rs1742473 chr16:1953095 T/C cg03013636 chr16:1946785 NA 0.55 6.89 0.36 2.82e-11 Glomerular filtration rate in chronic kidney disease; CRC cis rs7635838 0.617 rs13071193 chr3:11284226 G/T cg00170343 chr3:11313890 ATG7 -0.57 -8.91 -0.44 3.6e-17 HDL cholesterol; CRC trans rs916888 0.647 rs199523 chr17:44848517 C/A cg10053473 chr17:62856997 LRRC37A3 0.66 9.12 0.45 7.86e-18 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs728616 0.510 rs35671072 chr10:82172255 A/G cg05935833 chr10:81318306 SFTPA2 -0.56 -6.86 -0.35 3.32e-11 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs2120019 0.938 rs8036573 chr15:75308690 C/T cg09165964 chr15:75287851 SCAMP5 -0.88 -13.59 -0.6 1.11e-33 Blood trace element (Zn levels); CRC trans rs7395662 1.000 rs4882129 chr11:48588774 T/C cg21153622 chr11:89784906 NA -0.46 -7.35 -0.38 1.54e-12 HDL cholesterol; CRC cis rs11098499 0.691 rs9996644 chr4:120238877 G/T cg24375607 chr4:120327624 NA 0.48 7.64 0.39 2.41e-13 Corneal astigmatism; CRC cis rs6502050 0.835 rs56232956 chr17:80078929 C/T cg25804541 chr17:80189381 SLC16A3 0.31 6.01 0.31 4.93e-9 Life satisfaction; CRC cis rs6831352 0.879 rs34360292 chr4:100051303 T/C cg13256891 chr4:100009986 ADH5 -0.66 -8.89 -0.44 4.04e-17 Alcohol dependence; CRC cis rs7493 1.000 rs2068604 chr7:95041542 G/T cg04155289 chr7:94953770 PON1 -0.6 -7.41 -0.38 1.05e-12 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs3751196 0.710 rs55993375 chr12:104220684 T/C cg02344784 chr12:104178138 NT5DC3 0.71 7.28 0.37 2.55e-12 Sense of smell; CRC cis rs10256972 0.706 rs12701969 chr7:1121849 A/G cg18402987 chr7:1209562 NA 0.42 5.92 0.31 7.97e-9 Longevity;Endometriosis; CRC trans rs1814175 0.645 rs11040703 chr11:50024961 C/T cg03929089 chr4:120376271 NA -0.88 -15.84 -0.66 2.09e-42 Height; CRC cis rs644799 1.000 rs2508289 chr11:95624669 A/G cg25478527 chr11:95522999 CEP57;FAM76B 0.5 7.4 0.38 1.13e-12 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC trans rs7615952 0.558 rs7641353 chr3:125339879 T/C cg17147758 chr8:6949321 NA -0.52 -7.18 -0.37 4.67e-12 Blood pressure (smoking interaction); CRC cis rs6951245 0.744 rs10265736 chr7:1172465 C/T cg03188948 chr7:1209495 NA 0.64 7.21 0.37 3.87e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs2836950 0.565 rs2150413 chr21:40614878 C/T cg06238570 chr21:40685208 BRWD1 -0.64 -9.41 -0.46 8.65e-19 Menarche (age at onset); CRC cis rs6570726 0.791 rs1509214 chr6:145784606 A/C cg13319975 chr6:146136371 FBXO30 0.47 7.31 0.37 2e-12 Lobe attachment (rater-scored or self-reported); CRC cis rs7208859 0.673 rs216420 chr17:28938508 C/T cg01831904 chr17:28903510 LRRC37B2 -0.52 -6.01 -0.31 4.86e-9 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC trans rs7618501 1.000 rs2271961 chr3:49878113 C/T cg21582582 chr3:182698605 DCUN1D1 -0.52 -7.7 -0.39 1.56e-13 Intelligence (multi-trait analysis); CRC cis rs56104184 0.725 rs4347731 chr19:49385154 A/G cg15549821 chr19:49342101 PLEKHA4 -0.68 -6.81 -0.35 4.51e-11 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; CRC cis rs1552244 1.000 rs7631678 chr3:10078816 T/G cg00166722 chr3:10149974 C3orf24 0.71 9.49 0.46 4.86e-19 Alzheimer's disease; CRC cis rs4665809 0.590 rs13006973 chr2:26454707 C/T cg08067268 chr2:26466485 HADHB;HADHA 0.65 8.34 0.42 2e-15 Gut microbiome composition (summer); CRC cis rs6951245 0.554 rs10270249 chr7:1151886 G/T cg26224354 chr7:1096374 C7orf50;GPR146 -0.58 -7.9 -0.4 4.16e-14 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs1153858 1.000 rs12909158 chr15:45621174 A/G cg14582100 chr15:45693742 SPATA5L1 0.29 5.97 0.31 6.12e-9 Homoarginine levels; CRC cis rs601339 0.938 rs1696345 chr12:123183060 T/G cg22192744 chr12:123187474 GPR109A -0.4 -5.61 -0.3 4.33e-8 Adiponectin levels; CRC cis rs853679 0.769 rs7752608 chr6:28301195 A/G cg06470822 chr6:28175283 NA 0.72 5.76 0.3 1.89e-8 Depression; CRC cis rs9291683 0.530 rs11723591 chr4:9985398 T/A cg11266682 chr4:10021025 SLC2A9 0.51 10.38 0.5 4.96e-22 Bone mineral density; CRC cis rs1670533 0.872 rs10017931 chr4:1060747 G/A cg27284194 chr4:1044797 NA 0.44 5.74 0.3 2.13e-8 Recombination rate (females); CRC cis rs769267 0.930 rs2099334 chr19:19578450 A/G cg01262667 chr19:19385393 TM6SF2 0.36 5.84 0.31 1.25e-8 Tonsillectomy; CRC cis rs1707322 0.686 rs1547924 chr1:46085112 C/T cg03146154 chr1:46216737 IPP 0.67 9.49 0.46 4.72e-19 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs1005277 0.691 rs2474558 chr10:38486141 A/C cg00409905 chr10:38381863 ZNF37A 0.59 9.03 0.45 1.52e-17 Extrinsic epigenetic age acceleration; CRC cis rs7208859 0.623 rs80355557 chr17:29154421 C/T cg13385521 chr17:29058706 SUZ12P 0.64 7.34 0.38 1.63e-12 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs2013441 1.000 rs2058971 chr17:20219508 T/A cg13482628 chr17:19912719 NA -0.42 -6.55 -0.34 2.25e-10 Obesity-related traits; CRC cis rs2762353 0.595 rs13194155 chr6:25755508 C/T cg03517284 chr6:25882590 NA 0.74 10.46 0.5 2.8e-22 Blood metabolite levels; CRC cis rs6502050 0.835 rs7219138 chr17:80079896 C/T cg02741985 chr17:80059408 CCDC57 -0.44 -7.17 -0.37 4.96e-12 Life satisfaction; CRC cis rs7727544 0.716 rs10058655 chr5:131570896 A/T cg18758796 chr5:131593413 PDLIM4 0.36 6.46 0.34 3.74e-10 Blood metabolite levels; CRC cis rs7580658 0.724 rs71414745 chr2:127992588 A/G cg09760422 chr2:128146352 NA -0.29 -5.64 -0.3 3.61e-8 Protein C levels; CRC cis rs4737010 0.644 rs555466 chr8:41610346 G/A cg17182837 chr8:41585554 ANK1 0.52 7.49 0.38 6.54e-13 Lymphocyte counts;High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Reticulocyte count;Reticulocyte fraction of red cells;Mean corpuscular volume;Immature fraction of reticulocytes;Mean corpuscular hemoglobin concentration; CRC cis rs7927592 0.913 rs4084149 chr11:68288567 A/G cg16797656 chr11:68205561 LRP5 0.37 5.89 0.31 9.67e-9 Total body bone mineral density; CRC cis rs7605827 0.930 rs7605727 chr2:15598693 A/G cg19274914 chr2:15703543 NA 0.4 6.04 0.32 4.18e-9 Educational attainment (years of education); CRC cis rs898097 0.841 rs2271918 chr17:80861206 A/G cg19046167 chr17:80928561 B3GNTL1 -0.45 -6.67 -0.35 1.07e-10 Breast cancer; CRC cis rs7811142 1.000 rs11763414 chr7:100016844 C/G cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.19 17.8 0.7 4.05e-50 Platelet count; CRC cis rs10751667 0.643 rs10902237 chr11:944801 C/A cg06064525 chr11:970664 AP2A2 -0.35 -6.91 -0.36 2.51e-11 Alzheimer's disease (late onset); CRC trans rs8002861 0.664 rs1466005 chr13:44424210 T/C cg17145862 chr1:211918768 LPGAT1 0.58 9.94 0.48 1.58e-20 Leprosy; CRC cis rs11628318 0.570 rs2896450 chr14:103076595 T/C cg08075719 chr14:103021372 NA -0.67 -7.91 -0.4 3.96e-14 Platelet count; CRC cis rs7493 0.901 rs17883318 chr7:94958312 G/A cg17330251 chr7:94953956 PON1 -0.48 -6.78 -0.35 5.6e-11 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs651907 0.557 rs34624546 chr3:101374226 T/G cg12386194 chr3:101231763 SENP7 0.49 7.12 0.37 7.01e-12 Colorectal cancer; CRC cis rs7666738 0.830 rs13108422 chr4:99059267 G/A cg17366294 chr4:99064904 C4orf37 0.44 7.36 0.38 1.44e-12 Colonoscopy-negative controls vs population controls; CRC cis rs11608355 1.000 rs7970482 chr12:109862335 G/A cg19025524 chr12:109796872 NA -0.47 -6.68 -0.35 1.02e-10 Neuroticism; CRC cis rs4665809 1.000 rs4665817 chr2:26305167 G/A cg25036284 chr2:26402008 FAM59B -0.47 -5.88 -0.31 9.99e-9 Gut microbiome composition (summer); CRC cis rs8105895 0.935 rs4542784 chr19:22239751 G/A cg02657401 chr19:22469223 NA -0.34 -5.65 -0.3 3.56e-8 Body mass index (change over time); CRC cis rs892961 1.000 rs11077907 chr17:75400706 G/A cg05865280 chr17:75406074 SEPT9 0.58 11.98 0.55 1.12e-27 Airflow obstruction; CRC cis rs5167 0.566 rs204905 chr19:45460764 G/A cg09555818 chr19:45449301 APOC2 0.33 5.75 0.3 2.07e-8 Blood protein levels; CRC cis rs1023500 0.573 rs133380 chr22:42468910 C/T cg25452165 chr22:42524984 CYP2D6 0.42 6.37 0.33 6.36e-10 Schizophrenia; CRC cis rs2243480 1.000 rs778704 chr7:65863467 T/C cg25985355 chr7:65971099 NA -0.53 -5.98 -0.31 5.75e-9 Diabetic kidney disease; CRC cis rs877282 0.898 rs12357016 chr10:765675 C/T cg17470449 chr10:769945 NA 0.64 8.08 0.41 1.28e-14 Uric acid levels; CRC cis rs8060686 0.516 rs7194894 chr16:68145062 C/T cg26727032 chr16:67993705 SLC12A4 -0.6 -8.11 -0.41 1.04e-14 HDL cholesterol;Metabolic syndrome; CRC cis rs17685 0.712 rs11770149 chr7:75791644 G/A cg16489192 chr7:75678113 MDH2;STYXL1 -0.38 -5.89 -0.31 9.69e-9 Coffee consumption;Coffee consumption (cups per day); CRC cis rs9462027 0.628 rs6937132 chr6:34799221 T/A cg07306190 chr6:34760872 UHRF1BP1 -0.34 -6.09 -0.32 3.16e-9 Systemic lupus erythematosus; CRC cis rs12497850 0.931 rs6446196 chr3:49004723 A/G cg07636037 chr3:49044803 WDR6 1.03 18.31 0.71 3.83e-52 Parkinson's disease; CRC cis rs6964587 0.839 rs6949881 chr7:91433827 C/T cg17063962 chr7:91808500 NA 0.67 10.84 0.51 1.26e-23 Breast cancer; CRC cis rs1580019 0.534 rs13237495 chr7:32560687 A/G cg14728415 chr7:32535168 LSM5;AVL9 0.43 6.16 0.32 2.08e-9 Cognitive ability; CRC cis rs2243480 1.000 rs316334 chr7:65602126 G/T cg25985355 chr7:65971099 NA -0.52 -5.98 -0.31 5.86e-9 Diabetic kidney disease; CRC cis rs644799 0.965 rs10831430 chr11:95509638 T/C cg25478527 chr11:95522999 CEP57;FAM76B 0.53 7.79 0.39 8.67e-14 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs950169 0.881 rs4081123 chr15:84956235 A/G cg11189052 chr15:85197271 WDR73 0.63 8.8 0.44 7.65e-17 Schizophrenia; CRC cis rs514406 0.689 rs7548389 chr1:53404211 C/T cg08859206 chr1:53392774 SCP2 -0.6 -9.8 -0.48 4.79e-20 Monocyte count; CRC cis rs4713118 0.666 rs2893930 chr6:27738806 T/C cg25164649 chr6:28176230 NA 0.7 7.91 0.4 3.86e-14 Parkinson's disease; CRC cis rs11212617 0.967 rs12272183 chr11:108077181 A/G cg14761454 chr11:108092087 ATM;NPAT 0.38 5.7 0.3 2.65e-8 Response to metformin in type 2 diabetes (glycemic); CRC cis rs4713118 0.715 rs200480 chr6:27773664 A/G cg06470822 chr6:28175283 NA 0.64 9.08 0.45 1.04e-17 Parkinson's disease; CRC cis rs6062302 0.522 rs13038448 chr20:62218453 C/T cg06363034 chr20:62225388 GMEB2 -0.43 -6.66 -0.34 1.13e-10 Glioblastoma; CRC cis rs2760061 0.819 rs1745417 chr1:228204279 C/T cg18477163 chr1:228402036 OBSCN 0.4 6.76 0.35 6.24e-11 Diastolic blood pressure; CRC cis rs2976388 0.609 rs2164308 chr8:143785659 A/G cg04969067 chr8:143858791 LYNX1 -0.42 -7.08 -0.36 8.99e-12 Urinary tract infection frequency; CRC cis rs72730918 0.618 rs1531156 chr15:51990057 G/T cg14296394 chr15:51910925 DMXL2 0.45 5.79 0.3 1.6e-8 Intelligence (multi-trait analysis); CRC trans rs9329221 0.683 rs658385 chr8:9892177 C/T cg16141378 chr3:129829833 LOC729375 0.41 6.21 0.32 1.56e-9 Neuroticism; CRC cis rs9584850 0.834 rs7334078 chr13:99120484 C/T cg20750642 chr13:99100586 FARP1 0.39 5.7 0.3 2.7e-8 Neuroticism; CRC cis rs853679 0.517 rs67878650 chr6:28142587 G/C cg23161317 chr6:28129485 ZNF389 0.54 6.47 0.34 3.49e-10 Depression; CRC cis rs2115630 0.846 rs8024538 chr15:85368419 A/T cg11189052 chr15:85197271 WDR73 -0.61 -9.82 -0.48 3.83e-20 P wave terminal force; CRC cis rs7618915 0.547 rs11130315 chr3:52697163 A/G cg05573699 chr3:52720067 GNL3;PBRM1 -0.47 -6.77 -0.35 6.02e-11 Bipolar disorder; CRC cis rs9372498 0.536 rs9481825 chr6:118876092 C/T cg18833306 chr6:118973337 C6orf204 0.44 5.98 0.31 5.77e-9 Diastolic blood pressure; CRC cis rs875971 0.545 rs7783889 chr7:65748353 T/A cg18876405 chr7:65276391 NA 0.45 6.32 0.33 8.5e-10 Aortic root size; CRC cis rs9302065 0.681 rs9524903 chr13:95963565 A/G cg26751094 chr13:95954534 ABCC4 -0.33 -5.87 -0.31 1.08e-8 Blood metabolite levels; CRC cis rs2404602 0.735 rs2454450 chr15:76831236 G/A cg03037974 chr15:76606532 NA -0.49 -7.29 -0.37 2.37e-12 Blood metabolite levels; CRC cis rs8062405 0.755 rs4787455 chr16:28589455 G/A cg05139728 chr16:28306816 SBK1 -0.37 -6.12 -0.32 2.74e-9 Cognitive ability (multi-trait analysis);Cognitive ability; CRC cis rs6706785 0.660 rs6727608 chr2:240443992 T/C cg03276489 chr2:240449683 NA -0.53 -6.41 -0.33 4.98e-10 Conotruncal heart defects; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg03195230 chr11:64073135 ESRRA 0.44 6.0 0.31 5.09e-9 Anxiety disorder; CRC trans rs2380220 1.000 rs6931299 chr6:95969842 A/T cg09420816 chr15:77925960 LINGO1 -0.59 -6.19 -0.32 1.77e-9 Behavioural disinhibition (generation interaction); CRC cis rs2235649 0.623 rs8048162 chr16:1848918 C/T cg00935504 chr16:1863053 HAGH 0.31 5.62 0.3 4.07e-8 Blood metabolite levels; CRC cis rs977987 0.778 rs7206541 chr16:75436713 A/T cg03315344 chr16:75512273 CHST6 0.54 9.08 0.45 1.01e-17 Dupuytren's disease; CRC cis rs7727544 0.548 rs4705938 chr5:131694077 A/G cg18758796 chr5:131593413 PDLIM4 0.34 5.96 0.31 6.35e-9 Blood metabolite levels; CRC cis rs7264396 0.563 rs2066066 chr20:34329359 T/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.48 -6.57 -0.34 1.92e-10 Total cholesterol levels; CRC cis rs10504073 0.647 rs12549138 chr8:50007203 C/T cg00325661 chr8:49890786 NA 0.53 9.48 0.46 5.15e-19 Blood metabolite ratios; CRC cis rs1448094 0.512 rs57278040 chr12:86237886 A/G cg18827107 chr12:86230957 RASSF9 -0.47 -7.82 -0.4 7.27e-14 Major depressive disorder; CRC trans rs1590305 0.686 rs7337526 chr13:38061307 C/T cg03965764 chr11:45248109 NA -0.61 -6.17 -0.32 2.01e-9 Hip geometry; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg20355731 chr12:37942439 NA 0.44 6.83 0.35 4.2e-11 Liver disease severity in Alagille syndrome; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg27231188 chr1:233464510 KIAA1804 0.47 6.78 0.35 5.5e-11 Thyroid stimulating hormone; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg10902427 chr5:176944034 DDX41 0.45 7.56 0.38 4.16e-13 Liver disease severity in Alagille syndrome; CRC cis rs9549367 0.713 rs1323315 chr13:113859658 T/C cg00898013 chr13:113819073 PROZ 0.5 7.42 0.38 1.03e-12 Platelet distribution width; CRC cis rs6076065 0.748 rs2424542 chr20:23386800 C/T cg11657817 chr20:23433608 CST11 0.52 8.76 0.43 1.07e-16 Facial morphology (factor 15, philtrum width); CRC cis rs12142240 0.698 rs17357635 chr1:46808668 G/A cg00530320 chr1:46809349 NSUN4 0.58 7.98 0.4 2.46e-14 Menopause (age at onset); CRC trans rs2303319 0.504 rs56260047 chr2:162497225 G/T cg10272801 chr16:14013773 ERCC4 -0.67 -6.07 -0.32 3.6e-9 Cognitive function; CRC cis rs6938 0.575 rs12902515 chr15:75160998 G/C cg14664628 chr15:75095509 CSK -0.65 -10.45 -0.5 2.94e-22 Breast cancer; CRC cis rs7927592 0.913 rs67005337 chr11:68307758 A/C cg01657329 chr11:68192670 LRP5 -0.46 -6.58 -0.34 1.89e-10 Total body bone mineral density; CRC cis rs7258465 0.931 rs8107347 chr19:18612748 G/A cg01065977 chr19:18549689 ISYNA1 -0.41 -6.41 -0.33 5.1e-10 Breast cancer; CRC cis rs2404602 0.647 rs3812909 chr15:77176200 A/T cg03037974 chr15:76606532 NA -0.55 -8.23 -0.41 4.29e-15 Blood metabolite levels; CRC cis rs78456975 0.941 rs6755875 chr2:1557109 T/C cg26248373 chr2:1572462 NA -0.64 -7.08 -0.36 8.94e-12 Placebo response in major depressive disorder (% change in symptom score); CRC cis rs17767294 0.611 rs66487884 chr6:28202912 C/G cg15845792 chr6:28175446 NA 0.88 8.42 0.42 1.18e-15 Parkinson's disease; CRC cis rs6570726 0.791 rs6912079 chr6:145894949 G/A cg13319975 chr6:146136371 FBXO30 -0.45 -6.58 -0.34 1.85e-10 Lobe attachment (rater-scored or self-reported); CRC cis rs4073416 0.535 rs7150448 chr14:65871502 C/T cg03016385 chr14:66212404 NA -0.43 -5.86 -0.31 1.11e-8 N-glycan levels; CRC cis rs9649213 0.574 rs7789440 chr7:97888798 G/T cg00277769 chr7:97922759 BAIAP2L1 -0.6 -10.29 -0.49 1.01e-21 Prostate cancer (SNP x SNP interaction); CRC cis rs1475911 1.000 rs2839466 chr21:43512324 A/G cg19766460 chr21:43528205 UMODL1;C21orf128 -0.66 -8.0 -0.4 2.14e-14 IgG glycosylation; CRC cis rs9611565 0.694 rs202613 chr22:41821993 C/A cg06481639 chr22:41940642 POLR3H 0.51 5.63 0.3 3.96e-8 Vitiligo; CRC cis rs2346177 0.874 rs11125075 chr2:46656344 A/G cg26688816 chr2:46740690 ATP6V1E2 -0.48 -7.08 -0.36 8.77e-12 HDL cholesterol; CRC cis rs477692 1.000 rs4750759 chr10:131436603 G/A cg05714579 chr10:131428358 MGMT -0.51 -7.58 -0.39 3.66e-13 Response to temozolomide; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg18827097 chr2:3522506 ADI1 0.48 7.08 0.36 8.82e-12 Response to antipsychotic treatment; CRC cis rs28386778 0.897 rs2665832 chr17:61912261 C/T cg06601766 chr17:61851465 DDX42;CCDC47 0.44 6.01 0.31 4.88e-9 Prudent dietary pattern; CRC cis rs11098499 0.779 rs7699346 chr4:120310542 C/T cg09307838 chr4:120376055 NA 0.71 10.95 0.52 5.3e-24 Corneal astigmatism; CRC cis rs4689388 0.926 rs10937718 chr4:6295217 T/C cg25554036 chr4:6271136 WFS1 0.53 8.7 0.43 1.59e-16 Type 2 diabetes and other traits;Type 2 diabetes; CRC cis rs34524635 1 rs34524635 chr10:65261176 CT/C cg08743896 chr10:65200160 JMJD1C -0.41 -5.9 -0.31 8.92e-9 Vascular endothelial growth factor levels; CRC cis rs3741404 0.560 rs7938819 chr11:63910116 G/A cg19465662 chr11:63993652 NUDT22;TRPT1 -0.75 -12.05 -0.55 6.16e-28 Platelet count; CRC cis rs10504229 1.000 rs72650885 chr8:58175131 G/A cg05313129 chr8:58192883 C8orf71 -0.47 -6.99 -0.36 1.49e-11 Developmental language disorder (linguistic errors); CRC cis rs11123610 0.679 rs34705357 chr2:3716032 C/T cg10645314 chr2:3704589 ALLC -0.47 -5.83 -0.31 1.31e-8 Response to inhaled corticosteroid treatment in asthma (change in FEV1); CRC cis rs208520 0.690 rs7764570 chr6:66827600 G/C cg07460842 chr6:66804631 NA -1.01 -14.0 -0.61 3.04e-35 Exhaled nitric oxide output; CRC cis rs4926298 1.000 rs1077151 chr19:13151108 A/G cg23899408 chr19:12877188 HOOK2 -0.47 -6.5 -0.34 2.99e-10 Bipolar disorder; CRC cis rs2692947 0.800 rs4332959 chr2:96549121 C/T cg22654517 chr2:96458247 NA 0.33 6.02 0.32 4.57e-9 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; CRC cis rs2836950 0.545 rs8132143 chr21:40584258 A/T cg17971929 chr21:40555470 PSMG1 -0.59 -8.65 -0.43 2.27e-16 Menarche (age at onset); CRC trans rs6956675 1.000 rs6968327 chr7:62574489 A/G cg01314568 chr7:57830625 NA -0.67 -9.18 -0.45 4.9e-18 Obesity-related traits; CRC cis rs950169 0.840 rs4842854 chr15:84942339 T/G cg11189052 chr15:85197271 WDR73 0.63 8.8 0.44 7.65e-17 Schizophrenia; CRC cis rs1843834 0.539 rs1494109 chr2:225441833 G/A cg22455342 chr2:225449267 CUL3 0.68 9.02 0.45 1.55e-17 IgE levels in asthmatics (D.p. specific); CRC cis rs3772130 0.962 rs9822949 chr3:121541239 T/G cg20356878 chr3:121714668 ILDR1 0.51 7.93 0.4 3.43e-14 Cognitive performance; CRC cis rs7043114 0.507 rs6479420 chr9:95116406 T/C cg13798575 chr9:95087839 CENPP;NOL8 -0.4 -5.87 -0.31 1.07e-8 Height; CRC cis rs11190604 1.000 rs2495750 chr10:102327708 A/G cg16342193 chr10:102329863 NA -0.35 -5.89 -0.31 9.59e-9 Palmitoleic acid (16:1n-7) levels; CRC cis rs9649213 0.593 rs7797943 chr7:97946902 T/C cg24562669 chr7:97807699 LMTK2 0.42 6.95 0.36 1.95e-11 Prostate cancer (SNP x SNP interaction); CRC cis rs875971 1.000 rs4717292 chr7:65895598 G/A cg12463550 chr7:65579703 CRCP 0.48 6.78 0.35 5.54e-11 Aortic root size; CRC cis rs3857067 1.000 rs28876091 chr4:95000394 A/G cg11021082 chr4:95130006 SMARCAD1 -0.4 -6.04 -0.32 4.06e-9 QT interval; CRC cis rs8077889 0.956 rs4793026 chr17:41850508 A/G cg25876840 chr17:41920477 NA 0.44 6.55 0.34 2.26e-10 Triglycerides; CRC cis rs1348850 0.668 rs13010396 chr2:178492934 T/C cg02961200 chr2:178257176 LOC100130691;AGPS 0.46 5.84 0.31 1.26e-8 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs1552244 0.882 rs66559400 chr3:10012551 G/A cg10729496 chr3:10149963 C3orf24 0.49 6.38 0.33 5.96e-10 Alzheimer's disease; CRC cis rs6951245 1.000 rs113575110 chr7:1084394 G/A cg04025307 chr7:1156635 C7orf50 0.64 6.69 0.35 9.78e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs10789491 1.000 rs4553120 chr1:47165729 C/T cg15501359 chr1:47185051 KIAA0494 0.72 8.56 0.43 4.45e-16 Response to hepatitis C treatment; CRC cis rs4253772 0.591 rs6519993 chr22:46656479 A/G cg09491104 chr22:46646882 C22orf40 -0.48 -7.41 -0.38 1.1e-12 LDL cholesterol;Cholesterol, total; CRC cis rs5750830 0.649 rs5750820 chr22:39825322 T/G cg25956985 chr22:39795188 MAP3K7IP1 -0.47 -6.83 -0.35 4.04e-11 Intelligence (multi-trait analysis); CRC cis rs11098499 0.863 rs1480936 chr4:120462861 C/T cg24375607 chr4:120327624 NA 0.48 7.43 0.38 9.4e-13 Corneal astigmatism; CRC cis rs9486715 0.838 rs9386576 chr6:96954717 C/T cg06623918 chr6:96969491 KIAA0776 1.02 20.45 0.75 1.42e-60 Headache; CRC cis rs7208859 0.573 rs4055105 chr17:29102550 A/G cg01831904 chr17:28903510 LRRC37B2 -0.62 -6.44 -0.33 4.27e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs10504229 0.728 rs17215676 chr8:58152915 G/T cg24829409 chr8:58192753 C8orf71 -0.58 -7.96 -0.4 2.86e-14 Developmental language disorder (linguistic errors); CRC cis rs1129187 0.902 rs10948059 chr6:42928461 C/T cg27588902 chr6:42928151 GNMT -0.39 -7.19 -0.37 4.46e-12 Alzheimer's disease in APOE e4+ carriers; CRC cis rs763121 0.853 rs5757211 chr22:39051705 C/T cg06022373 chr22:39101656 GTPBP1 0.77 12.08 0.55 4.67e-28 Menopause (age at onset); CRC cis rs2075671 0.903 rs62483570 chr7:100300649 C/T cg16850897 chr7:100343110 ZAN -0.62 -9.02 -0.45 1.61e-17 Other erythrocyte phenotypes; CRC cis rs916888 0.821 rs199513 chr17:44856932 A/G cg01570182 chr17:44337453 NA -0.97 -11.61 -0.54 2.4e-26 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg15099042 chr20:44563274 PCIF1 0.46 6.44 0.33 4.28e-10 Anxiety disorder; CRC cis rs4664293 0.836 rs2556102 chr2:160655122 C/T cg08347373 chr2:160653686 CD302 -0.51 -7.87 -0.4 5.14e-14 Monocyte percentage of white cells; CRC cis rs8062405 0.755 rs56209193 chr16:28585636 C/T cg16576597 chr16:28551801 NUPR1 0.52 7.5 0.38 5.99e-13 Cognitive ability (multi-trait analysis);Cognitive ability; CRC cis rs10504229 0.683 rs11785260 chr8:58132906 A/G cg05313129 chr8:58192883 C8orf71 -0.43 -6.11 -0.32 2.74e-9 Developmental language disorder (linguistic errors); CRC trans rs2303319 0.504 rs1006428 chr2:162592559 A/C cg13490827 chr1:46269305 MAST2 -0.69 -6.0 -0.31 5.24e-9 Cognitive function; CRC trans rs916888 0.821 rs199514 chr17:44856881 G/A cg10053473 chr17:62856997 LRRC37A3 0.69 7.93 0.4 3.51e-14 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs67311347 1.000 rs4571217 chr3:40521973 A/G cg09455208 chr3:40491958 NA 0.51 10.49 0.5 2.05e-22 Renal cell carcinoma; CRC cis rs1971762 0.583 rs12319789 chr12:54090450 G/C cg06632207 chr12:54070931 ATP5G2 0.4 6.76 0.35 6.3e-11 Height; CRC cis rs172166 0.516 rs1225710 chr6:28100640 C/T cg15845792 chr6:28175446 NA -0.63 -9.49 -0.46 4.81e-19 Cardiac Troponin-T levels; CRC cis rs116095464 0.558 rs10462754 chr5:246669 T/C cg22496380 chr5:211416 CCDC127 -0.91 -10.37 -0.5 5.56e-22 Breast cancer; CRC cis rs11098499 0.754 rs7689729 chr4:120256192 A/G cg24375607 chr4:120327624 NA 0.47 7.45 0.38 8.16e-13 Corneal astigmatism; CRC cis rs9311474 0.629 rs13081028 chr3:52555316 G/A cg07507251 chr3:52567010 NT5DC2 0.5 7.83 0.4 6.71e-14 Electroencephalogram traits; CRC cis rs7932354 0.528 rs10838660 chr11:47152273 C/T cg03339077 chr11:47165057 C11orf49 0.44 6.27 0.33 1.14e-9 Bone mineral density (hip);Bone mineral density; CRC cis rs2243480 0.901 rs2456483 chr7:65461575 T/C cg18252515 chr7:66147081 NA -1.06 -12.27 -0.56 9.34e-29 Diabetic kidney disease; CRC trans rs3845702 0.736 rs16867131 chr2:180848651 A/G cg25411327 chr19:5210703 PTPRS 0.58 6.0 0.31 5.21e-9 Schizophrenia; CRC trans rs4684776 0.606 rs17833547 chr3:11655204 T/C cg20302342 chr1:156215951 PAQR6 -0.45 -6.04 -0.32 4.27e-9 Small vessel stroke; CRC trans rs4687833 0.874 rs1468738 chr3:118631621 C/A cg20439624 chr19:44010874 ETHE1 -0.45 -6.04 -0.32 4.13e-9 Lung function (forced expiratory flow during mid-portion (25% and 75%) of forced vital capacity); CRC trans rs1814175 0.817 rs7924619 chr11:49620632 G/A cg03929089 chr4:120376271 NA -0.95 -17.98 -0.7 8.09e-51 Height; CRC trans rs1945213 0.694 rs12422168 chr11:55866840 A/G cg03929089 chr4:120376271 NA 0.55 6.35 0.33 7.07e-10 Acute lymphoblastic leukemia (childhood); CRC cis rs7552404 0.883 rs11161493 chr1:76206254 T/A cg10523679 chr1:76189770 ACADM 0.94 14.31 0.62 1.87e-36 Blood metabolite levels;Acylcarnitine levels; CRC cis rs896854 0.625 rs4735335 chr8:95973327 G/C cg09323728 chr8:95962352 TP53INP1 -0.45 -7.47 -0.38 7.43e-13 Type 2 diabetes; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg02679955 chr17:73521473 LLGL2 0.43 5.96 0.31 6.48e-9 Response to antipsychotic treatment; CRC cis rs172166 0.516 rs2622322 chr6:28117443 C/G cg15845792 chr6:28175446 NA 0.64 9.61 0.47 1.97e-19 Cardiac Troponin-T levels; CRC cis rs9549260 0.564 rs4245402 chr13:41287540 C/T cg21288729 chr13:41239152 FOXO1 0.43 6.64 0.34 1.27e-10 Red blood cell count; CRC cis rs7666738 0.830 rs13138059 chr4:99050430 A/G cg17366294 chr4:99064904 C4orf37 0.46 7.78 0.39 9.74e-14 Colonoscopy-negative controls vs population controls; CRC cis rs11098499 0.535 rs10005542 chr4:120268302 T/C cg24375607 chr4:120327624 NA 0.47 7.57 0.39 3.86e-13 Corneal astigmatism; CRC trans rs2303319 0.504 rs12470743 chr2:162611202 G/A cg12500891 chr11:57225987 NA -0.65 -6.06 -0.32 3.77e-9 Cognitive function; CRC cis rs1552244 1.000 rs7611218 chr3:10063960 T/C cg18598329 chr3:10140678 FANCD2;C3orf24 -0.88 -12.22 -0.56 1.48e-28 Alzheimer's disease; CRC cis rs8060686 0.748 rs3785098 chr16:67993643 T/C cg07125278 chr16:67683757 RLTPR -0.44 -5.69 -0.3 2.78e-8 HDL cholesterol;Metabolic syndrome; CRC cis rs17376456 0.877 rs34673483 chr5:93315079 C/A cg21475434 chr5:93447410 FAM172A 0.79 8.19 0.41 5.81e-15 Diabetic retinopathy; CRC cis rs10193935 0.901 rs3088290 chr2:42578143 A/G cg27598129 chr2:42591480 NA -0.69 -7.77 -0.39 1.02e-13 Colonoscopy-negative controls vs population controls; CRC cis rs3858526 0.755 rs10769368 chr11:5962084 C/T cg05234568 chr11:5960015 NA 0.47 6.62 0.34 1.46e-10 DNA methylation (variation); CRC cis rs6089584 0.566 rs11699442 chr20:60623268 A/G cg23262073 chr20:60523788 NA -0.42 -6.69 -0.35 9.36e-11 Body mass index; CRC cis rs9372498 0.536 rs17080302 chr6:118854037 A/G cg07617317 chr6:118971624 C6orf204 0.5 6.26 0.33 1.22e-9 Diastolic blood pressure; CRC cis rs2075371 0.897 rs1643102 chr7:133999983 T/A cg11752832 chr7:134001865 SLC35B4 0.5 7.63 0.39 2.52e-13 Mean platelet volume; CRC cis rs9858542 0.953 rs6809216 chr3:49412559 G/A cg03060546 chr3:49711283 APEH -0.48 -6.85 -0.35 3.71e-11 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs9549367 0.789 rs2287248 chr13:113889226 T/C cg18105134 chr13:113819100 PROZ -0.72 -10.75 -0.51 2.75e-23 Platelet distribution width; CRC cis rs9381040 0.674 rs3747742 chr6:41162518 C/T cg04346459 chr6:41068666 NFYA;LOC221442 0.53 8.08 0.41 1.27e-14 Alzheimer's disease (late onset); CRC cis rs13144136 0.643 rs4339204 chr4:10661011 A/T cg10242279 chr4:10666415 CLNK -0.37 -6.47 -0.34 3.53e-10 Resistance to antihypertensive treatment in hypertension; CRC cis rs13108904 0.875 rs10024013 chr4:1280792 C/T cg05665937 chr4:1216051 CTBP1 -0.38 -5.83 -0.31 1.36e-8 Obesity-related traits; CRC cis rs7772486 0.713 rs2328704 chr6:146020494 T/C cg05347473 chr6:146136440 FBXO30 -0.38 -5.77 -0.3 1.83e-8 Lobe attachment (rater-scored or self-reported); CRC cis rs12286929 0.668 rs17304149 chr11:115049180 C/T cg04055981 chr11:115044050 NA 0.4 6.24 0.33 1.35e-9 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs1003719 0.737 rs2835587 chr21:38461795 A/T cg10648535 chr21:38446584 PIGP;TTC3 0.52 7.34 0.38 1.66e-12 Eye color traits; CRC cis rs11711311 0.712 rs2271498 chr3:113334752 A/G cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.48 -6.71 -0.35 8.48e-11 IgG glycosylation; CRC trans rs2303319 0.504 rs62189046 chr2:162612371 C/G cg22922770 chr7:98923339 ARPC1A -0.67 -5.98 -0.31 5.68e-9 Cognitive function; CRC cis rs727505 0.721 rs11536526 chr7:124749441 G/A cg23710748 chr7:124431027 NA -0.66 -11.34 -0.53 2.26e-25 Lewy body disease; CRC cis rs1707322 1.000 rs12124847 chr1:46380850 T/A cg06784218 chr1:46089804 CCDC17 0.6 10.83 0.51 1.4e-23 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs3812049 0.737 rs790154 chr5:127501235 A/G cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.73 9.02 0.45 1.6e-17 Lymphocyte counts;Red cell distribution width; CRC cis rs10242455 0.571 rs117370443 chr7:98975258 T/C cg18809830 chr7:99032528 PTCD1 -0.96 -7.13 -0.37 6.4e-12 Blood metabolite levels; CRC cis rs2180341 0.920 rs7756880 chr6:127683999 A/T cg24812749 chr6:127587940 RNF146 0.95 13.32 0.59 1.16e-32 Breast cancer; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg08064720 chr7:152131894 MLL3 0.46 6.55 0.34 2.19e-10 Response to antipsychotic treatment; CRC cis rs1223397 0.938 rs17767967 chr6:13282067 C/T cg20827128 chr6:13274284 PHACTR1 0.55 6.55 0.34 2.19e-10 Blood pressure; CRC cis rs6860806 0.507 rs156322 chr5:131653925 C/T cg24060327 chr5:131705240 SLC22A5 -0.52 -7.52 -0.38 5.09e-13 Breast cancer; CRC cis rs6952808 0.964 rs10950400 chr7:1882470 C/T cg22963979 chr7:1858916 MAD1L1 -0.64 -9.73 -0.47 8.04e-20 Bipolar disorder and schizophrenia; CRC cis rs1799949 1.000 rs11653460 chr17:41331306 C/T cg05368731 chr17:41323189 NBR1 0.67 9.93 0.48 1.65e-20 Menopause (age at onset); CRC cis rs72945132 0.882 rs17425511 chr11:70183737 C/G cg00319359 chr11:70116639 PPFIA1 0.65 6.51 0.34 2.81e-10 Coronary artery disease; CRC cis rs4285028 0.948 rs34478505 chr3:121694071 C/T cg20356878 chr3:121714668 ILDR1 -0.48 -6.92 -0.36 2.41e-11 Multiple sclerosis; CRC cis rs6860806 0.631 rs7736284 chr5:131588151 T/C cg22638593 chr5:131593259 PDLIM4 0.41 7.57 0.39 3.83e-13 Breast cancer; CRC cis rs2836974 0.897 rs35123057 chr21:40711689 C/T cg11890956 chr21:40555474 PSMG1 0.98 14.83 0.63 1.86e-38 Cognitive function; CRC cis rs798554 0.723 rs798518 chr7:2777825 A/G cg19346786 chr7:2764209 NA -0.41 -7.46 -0.38 7.78e-13 Height; CRC cis rs950169 1.000 rs79318564 chr15:84786150 G/A cg11189052 chr15:85197271 WDR73 0.61 8.94 0.44 2.8e-17 Schizophrenia; CRC cis rs7617480 0.648 rs9859473 chr3:48837182 A/G cg20833759 chr3:49053208 WDR6;DALRD3 0.74 11.74 0.54 7.86e-27 Subjective well-being (multi-trait analysis);Menarche (age at onset); CRC cis rs9435341 0.965 rs61798468 chr1:107569316 T/G cg15468180 chr1:107600409 PRMT6 0.39 5.79 0.3 1.66e-8 Facial morphology (factor 21, depth of nasal alae); CRC cis rs13108904 0.905 rs1680074 chr4:1279621 G/A cg20092199 chr4:1342459 KIAA1530 -0.42 -7.77 -0.39 1.02e-13 Obesity-related traits; CRC cis rs853679 0.506 rs1150693 chr6:28174590 T/C cg03623178 chr6:28175578 NA 0.94 13.49 0.6 2.5e-33 Depression; CRC cis rs929354 0.709 rs1182363 chr7:157019151 A/G cg05182265 chr7:156933206 UBE3C 0.77 14.67 0.63 7.87e-38 Body mass index; CRC cis rs11577318 0.796 rs4625269 chr1:26626967 C/A cg04990556 chr1:26633338 UBXN11 -0.48 -6.17 -0.32 2.06e-9 Granulocyte percentage of myeloid white cells; CRC cis rs10924970 0.687 rs10802438 chr1:235357543 A/G cg09010748 chr1:235293032 TOMM20 -0.41 -5.7 -0.3 2.6e-8 Asthma; CRC cis rs9660180 0.967 rs12044597 chr1:1708801 A/G cg17747265 chr1:1875780 NA -0.74 -12.74 -0.57 1.72e-30 Body mass index; CRC cis rs3092073 0.624 rs13040315 chr20:44585793 A/G cg27529037 chr20:44575021 PCIF1 0.4 7.09 0.36 8.03e-12 Intelligence (multi-trait analysis); CRC cis rs1799949 0.930 rs2298861 chr17:41176831 G/A cg19454999 chr17:41278357 BRCA1;NBR2 0.53 8.09 0.41 1.2e-14 Menopause (age at onset); CRC cis rs9303401 0.659 rs34351230 chr17:56782555 C/A cg02118635 chr17:56770003 RAD51C;TEX14 0.79 10.13 0.49 3.5e-21 Cognitive test performance; CRC cis rs12893668 0.572 rs12590968 chr14:104136633 G/C cg24130564 chr14:104152367 KLC1 -0.42 -5.63 -0.3 3.82e-8 Reticulocyte count; CRC cis rs611744 0.647 rs4735053 chr8:109260776 A/G cg21045802 chr8:109455806 TTC35 0.4 6.38 0.33 5.99e-10 Dupuytren's disease; CRC cis rs748404 0.660 rs690446 chr15:43761264 G/C cg02155558 chr15:43621948 ADAL;LCMT2 0.52 7.57 0.38 3.89e-13 Lung cancer; CRC cis rs12760731 0.582 rs12048597 chr1:178538316 T/A cg00404053 chr1:178313656 RASAL2 0.63 7.09 0.36 8.37e-12 Obesity-related traits; CRC cis rs7811142 0.945 rs6955362 chr7:100056166 C/T cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.17 17.51 0.69 5.94e-49 Platelet count; CRC cis rs11792861 0.816 rs72607157 chr9:111748001 T/G cg05043794 chr9:111880884 C9orf5 -0.33 -5.79 -0.3 1.69e-8 Menarche (age at onset); CRC cis rs7224685 0.569 rs34357603 chr17:4008760 G/A cg09597638 chr17:3907349 NA 0.45 5.77 0.3 1.8e-8 Type 2 diabetes; CRC trans rs875971 0.545 rs6969224 chr7:65834998 T/G cg02869306 chr7:64672164 INTS4L1 -0.45 -6.47 -0.34 3.49e-10 Aortic root size; CRC cis rs6502050 0.799 rs6502089 chr17:80169523 G/A cg22110888 chr17:80059540 CCDC57 0.42 6.64 0.34 1.33e-10 Life satisfaction; CRC cis rs8031584 0.918 rs34095794 chr15:31269691 C/T cg14829155 chr15:31115871 NA -0.49 -8.13 -0.41 8.67e-15 Huntington's disease progression; CRC cis rs7692995 1.000 rs34683079 chr4:17939302 T/C cg08925142 chr4:18023851 LCORL -0.52 -5.81 -0.31 1.45e-8 Height; CRC cis rs739401 0.611 rs7394974 chr11:3038868 C/T cg25174290 chr11:3078921 CARS 0.47 7.33 0.37 1.83e-12 Longevity; CRC trans rs9329221 0.736 rs11250002 chr8:10257041 T/G cg06636001 chr8:8085503 FLJ10661 0.5 7.47 0.38 7.39e-13 Neuroticism; CRC cis rs7772486 0.790 rs2265474 chr6:146182092 G/A cg13319975 chr6:146136371 FBXO30 -0.48 -7.16 -0.37 5.17e-12 Lobe attachment (rater-scored or self-reported); CRC cis rs9916302 0.768 rs62077464 chr17:37656056 C/G cg00129232 chr17:37814104 STARD3 -0.56 -8.2 -0.41 5.32e-15 Glomerular filtration rate (creatinine); CRC trans rs2727020 0.595 rs11040328 chr11:49339055 T/C cg21153622 chr11:89784906 NA -0.5 -8.35 -0.42 1.94e-15 Coronary artery disease; CRC cis rs853679 0.542 rs2295594 chr6:28053097 G/A cg12172441 chr6:28176163 NA 0.6 7.2 0.37 4.23e-12 Depression; CRC cis rs7617480 0.648 rs6766238 chr3:48801929 G/A cg07636037 chr3:49044803 WDR6 0.86 10.55 0.5 1.34e-22 Subjective well-being (multi-trait analysis);Menarche (age at onset); CRC cis rs881375 0.967 rs1930781 chr9:123687834 G/A cg14255062 chr9:123606675 PSMD5;LOC253039 0.41 5.95 0.31 6.99e-9 Rheumatoid arthritis; CRC cis rs7264396 0.635 rs6060692 chr20:34517925 A/T cg04508476 chr20:34239394 CPNE1;RBM12 0.62 10.78 0.51 2.09e-23 Total cholesterol levels; CRC cis rs11722228 1.000 rs6823877 chr4:9921931 T/C cg11266682 chr4:10021025 SLC2A9 -0.39 -6.75 -0.35 6.61e-11 Gout;Urate levels;Serum uric acid levels; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg17452277 chr8:110551976 EBAG9 0.41 6.37 0.33 6.43e-10 Liver disease severity in Alagille syndrome; CRC cis rs2067615 0.599 rs10778508 chr12:107159405 A/G cg13491945 chr12:107078410 RFX4 -0.34 -5.83 -0.31 1.32e-8 Heart rate; CRC cis rs6921919 0.583 rs7749736 chr6:28346031 G/C cg21251018 chr6:28226885 NKAPL 0.39 6.02 0.31 4.74e-9 Autism spectrum disorder or schizophrenia; CRC cis rs12479064 0.694 rs4341989 chr2:100046783 C/T cg26064155 chr2:99771622 LIPT1;TSGA10 -0.68 -8.45 -0.42 9.71e-16 Chronic sinus infection; CRC cis rs6860806 0.531 rs272887 chr5:131665713 A/G cg04518342 chr5:131593106 PDLIM4 0.42 6.81 0.35 4.51e-11 Breast cancer; CRC cis rs6570726 1.000 rs450076 chr6:145847655 G/T cg23711669 chr6:146136114 FBXO30 0.7 12.17 0.56 2.25e-28 Lobe attachment (rater-scored or self-reported); CRC cis rs9611565 0.659 rs12483786 chr22:41938536 A/G cg03806693 chr22:41940476 POLR3H -1.12 -14.83 -0.63 1.88e-38 Vitiligo; CRC cis rs651907 0.557 rs3094297 chr3:101399260 A/G cg12386194 chr3:101231763 SENP7 0.46 6.82 0.35 4.33e-11 Colorectal cancer; CRC cis rs4604732 0.527 rs7546805 chr1:247627259 G/A cg12754571 chr1:247694271 LOC148824;OR2C3 0.41 5.77 0.3 1.87e-8 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CRC cis rs28386778 0.897 rs4968598 chr17:61835579 T/C cg23090583 chr17:61904693 PSMC5;FTSJ3 1.04 20.64 0.75 2.54e-61 Prudent dietary pattern; CRC cis rs897984 0.537 rs8045637 chr16:30818662 C/T cg02466173 chr16:30829666 NA -0.88 -16.26 -0.67 4.65e-44 Dementia with Lewy bodies; CRC cis rs1580019 0.523 rs13236410 chr7:32690663 G/A cg14728415 chr7:32535168 LSM5;AVL9 0.46 6.53 0.34 2.51e-10 Cognitive ability; CRC cis rs57221529 0.766 rs56278696 chr5:582669 A/G cg16447950 chr5:562315 NA -0.81 -10.62 -0.51 7.76e-23 Lung disease severity in cystic fibrosis; CRC cis rs734999 0.566 rs12748729 chr1:2558740 C/T cg20673091 chr1:2541236 MMEL1 -0.37 -5.92 -0.31 7.9e-9 Ulcerative colitis; CRC cis rs9549328 0.700 rs4907568 chr13:113617574 A/T cg08614441 chr13:113633676 MCF2L -0.4 -7.07 -0.36 9.06e-12 Systolic blood pressure; CRC cis rs9457247 1.000 rs389946 chr6:167407268 T/C cg23791538 chr6:167370224 RNASET2 -0.39 -6.07 -0.32 3.55e-9 Crohn's disease; CRC cis rs9811920 0.609 rs793462 chr3:99616461 G/A cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G 0.46 6.18 0.32 1.87e-9 Axial length; CRC trans rs916888 0.779 rs199528 chr17:44843136 C/T cg01341218 chr17:43662625 NA 0.99 10.21 0.49 1.91e-21 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs832540 0.898 rs252888 chr5:56227326 T/A cg12311346 chr5:56204834 C5orf35 -0.5 -7.7 -0.39 1.5700000000000001e-13 Coronary artery disease; CRC cis rs2997447 0.633 rs11247848 chr1:26357667 G/A cg19633962 chr1:26362018 EXTL1 -0.57 -5.95 -0.31 7.01e-9 QRS complex (12-leadsum); CRC cis rs9527 0.544 rs1572578 chr10:104822431 C/G cg04362960 chr10:104952993 NT5C2 0.58 8.29 0.42 2.82e-15 Arsenic metabolism; CRC cis rs853679 0.517 rs36078605 chr6:28078032 A/C cg12273811 chr6:28175739 NA 0.72 9.05 0.45 1.25e-17 Depression; CRC cis rs4466137 0.830 rs6886442 chr5:82973210 A/C cg15083037 chr5:83017644 HAPLN1 0.51 7.33 0.37 1.83e-12 Prostate cancer; CRC cis rs1348850 0.914 rs2121430 chr2:178318375 A/G cg02961200 chr2:178257176 LOC100130691;AGPS 0.6 8.75 0.43 1.13e-16 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg01769160 chr11:20408933 PRMT3 0.44 6.14 0.32 2.34e-9 Response to antipsychotic treatment; CRC cis rs10870270 1.000 rs11146324 chr10:133767445 A/C cg08754478 chr10:133766260 PPP2R2D -0.66 -9.33 -0.46 1.67e-18 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; CRC cis rs9325144 0.555 rs2387855 chr12:38687964 T/G cg13010199 chr12:38710504 ALG10B 0.42 6.24 0.33 1.38e-9 Morning vs. evening chronotype; CRC cis rs28386778 0.863 rs6504178 chr17:61812733 A/G cg23090583 chr17:61904693 PSMC5;FTSJ3 -1.03 -19.57 -0.73 4.19e-57 Prudent dietary pattern; CRC cis rs911119 0.955 rs12625716 chr20:23606845 A/G cg16589663 chr20:23618590 CST3 -0.52 -6.95 -0.36 1.92e-11 Chronic kidney disease; CRC cis rs9463078 0.547 rs2038557 chr6:44740471 G/A cg25276700 chr6:44698697 NA 0.3 7.76 0.39 1.09e-13 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; CRC cis rs9649213 0.593 rs2107716 chr7:97944744 G/A cg21770322 chr7:97807741 LMTK2 0.51 8.38 0.42 1.57e-15 Prostate cancer (SNP x SNP interaction); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg05062674 chr16:89882627 FANCA 0.42 6.84 0.35 3.8e-11 Liver disease severity in Alagille syndrome; CRC cis rs11098499 0.615 rs28850368 chr4:120554313 G/A cg24375607 chr4:120327624 NA 0.48 7.5 0.38 6.14e-13 Corneal astigmatism; CRC cis rs629535 0.821 rs497398 chr8:70037434 A/T cg26132723 chr8:70041827 NA 0.35 5.72 0.3 2.41e-8 Dupuytren's disease; CRC cis rs875971 0.965 rs10267430 chr7:65743023 G/T cg18912574 chr7:65842487 NCRNA00174 -0.37 -6.33 -0.33 7.93e-10 Aortic root size; CRC cis rs3767633 0.925 rs1394070 chr1:161814020 T/G cg09175582 chr1:161736000 ATF6 0.69 6.26 0.33 1.18e-9 IgG glycosylation; CRC cis rs873946 0.586 rs12774727 chr10:134569910 T/C cg27286337 chr10:134555280 INPP5A 0.82 9.99 0.48 1.11e-20 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CRC cis rs6121246 0.954 rs73241710 chr20:30424956 G/A cg18721089 chr20:30220636 NA -0.36 -5.75 -0.3 2.07e-8 Mean corpuscular hemoglobin; CRC cis rs10504229 1.000 rs77823122 chr8:58170161 A/G cg05313129 chr8:58192883 C8orf71 -0.47 -6.99 -0.36 1.49e-11 Developmental language disorder (linguistic errors); CRC cis rs896854 1.000 rs7003387 chr8:95961979 C/G cg09323728 chr8:95962352 TP53INP1 -0.42 -6.79 -0.35 5.16e-11 Type 2 diabetes; CRC cis rs4700695 0.925 rs4700692 chr5:65396279 T/C cg21114390 chr5:65439923 SFRS12 -0.54 -6.87 -0.35 3.19e-11 Facial morphology (factor 19); CRC trans rs1814175 0.817 rs10769617 chr11:49810421 G/A cg03929089 chr4:120376271 NA -0.96 -18.51 -0.71 6.54e-53 Height; CRC cis rs853679 0.517 rs9393884 chr6:28046789 A/G cg02683197 chr6:28174875 NA 0.79 9.81 0.48 4.32e-20 Depression; CRC cis rs11212617 0.935 rs12792979 chr11:108335378 C/T cg01991180 chr11:108092276 ATM;NPAT -0.39 -5.61 -0.3 4.3e-8 Response to metformin in type 2 diabetes (glycemic); CRC cis rs8014671 0.597 rs8021180 chr14:70783943 A/G cg23609571 chr14:70655845 SLC8A3 -0.3 -6.14 -0.32 2.35e-9 Prostate cancer; CRC cis rs2295359 0.892 rs4655687 chr1:67649946 C/T cg03340356 chr1:67600835 NA 0.3 6.73 0.35 7.62e-11 Psoriasis; CRC trans rs1997103 0.822 rs940878 chr7:55419663 A/G cg20935933 chr6:143382018 AIG1 0.52 6.56 0.34 2.1e-10 QRS interval (sulfonylurea treatment interaction); CRC trans rs5417 0.775 rs222852 chr17:7140606 A/G cg15655154 chr3:113604241 GRAMD1C 0.53 9.11 0.45 8e-18 Diastolic blood pressure; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg01217080 chr12:54773536 ZNF385A 0.4 6.45 0.34 3.9e-10 Response to antipsychotic treatment; CRC cis rs7772486 0.743 rs9390344 chr6:146012755 C/G cg05347473 chr6:146136440 FBXO30 -0.37 -5.67 -0.3 3.13e-8 Lobe attachment (rater-scored or self-reported); CRC cis rs477895 0.713 rs67546972 chr11:63962162 G/A cg18225595 chr11:63971243 STIP1 0.61 8.14 0.41 7.99e-15 Mean platelet volume; CRC cis rs2859741 0.967 rs575939 chr1:37513854 T/C cg09363841 chr1:37513479 NA -0.62 -11.81 -0.55 4.59e-27 Forced expiratory volume in 1 second (environmental tobacco smoke interaction); CRC cis rs6834538 0.519 rs1843728 chr4:113413127 A/G cg10021238 chr4:113569128 MIR367;LARP7 -0.37 -5.78 -0.3 1.74e-8 Free thyroxine concentration; CRC cis rs1552244 1.000 rs2272125 chr3:10138069 A/C cg18598329 chr3:10140678 FANCD2;C3orf24 -0.9 -13.32 -0.59 1.17e-32 Alzheimer's disease; CRC cis rs6952808 1.000 rs59248873 chr7:1888185 A/G cg21782813 chr7:2030301 MAD1L1 0.4 6.91 0.36 2.55e-11 Bipolar disorder and schizophrenia; CRC cis rs7617480 0.648 rs6801211 chr3:48774420 C/G cg20833759 chr3:49053208 WDR6;DALRD3 0.67 10.88 0.51 9.12e-24 Subjective well-being (multi-trait analysis);Menarche (age at onset); CRC cis rs3789045 0.774 rs12039365 chr1:204488687 A/G cg17419461 chr1:204415978 PIK3C2B -0.57 -7.95 -0.4 3.06e-14 Educational attainment (college completion); CRC cis rs2072499 0.750 rs7534339 chr1:156156219 A/G cg24450063 chr1:156163899 SLC25A44 1.1 17.28 0.69 4.41e-48 Testicular germ cell tumor; CRC cis rs8041447 0.832 rs7350775 chr15:63056159 A/T cg12790106 chr15:63105204 TLN2 -0.41 -6.2 -0.32 1.64e-9 Immature fraction of reticulocytes; CRC cis rs7827545 0.545 rs1867062 chr8:135559079 G/A cg17885191 chr8:135476712 NA 0.66 7.65 0.39 2.3e-13 Hypertension (SNP x SNP interaction); CRC cis rs2108622 0.958 rs79400241 chr19:15984402 C/G cg13772218 chr19:15982569 NA 0.46 6.23 0.32 1.41e-9 Circulating phylloquinone levels;Vitamin E levels;Acenocoumarol maintenance dosage;Response to Vitamin E supplementation;Metabolite levels;Warfarin maintenance dose; CRC cis rs2976388 0.609 rs1594999 chr8:143790574 G/A cg15511327 chr8:143859410 LYNX1 0.42 7.45 0.38 8.2e-13 Urinary tract infection frequency; CRC trans rs800082 1.000 rs1405597 chr3:144314276 A/C cg24215973 chr2:240111563 HDAC4 -0.51 -7.2 -0.37 4.05e-12 Smoking behavior; CRC cis rs921968 0.643 rs524902 chr2:219433357 A/C cg02176678 chr2:219576539 TTLL4 0.49 7.88 0.4 4.72e-14 Mean corpuscular hemoglobin concentration; CRC cis rs2645694 0.626 rs2703151 chr4:77834095 A/G cg18351406 chr4:77819688 ANKRD56 0.42 6.26 0.33 1.22e-9 Emphysema distribution in smoking; CRC cis rs34779708 0.931 rs4934724 chr10:35393669 C/T cg03585969 chr10:35415529 CREM 0.66 8.77 0.44 9.7e-17 Inflammatory bowel disease;Crohn's disease; CRC cis rs28386778 0.897 rs2584626 chr17:61903179 A/G cg22520471 chr17:61851767 DDX42;CCDC47 0.75 11.75 0.54 7.35e-27 Prudent dietary pattern; CRC cis rs853679 1.000 rs10456362 chr6:28221816 A/G cg15845792 chr6:28175446 NA -0.59 -6.23 -0.32 1.44e-9 Depression; CRC cis rs12956009 0.583 rs16952069 chr18:44904220 T/A cg19077165 chr18:44547161 KATNAL2 -0.42 -6.07 -0.32 3.59e-9 Educational attainment (years of education); CRC cis rs7224685 0.501 rs7211478 chr17:3897178 C/T cg10724054 chr17:3904396 NA -0.46 -7.52 -0.38 5.33e-13 Type 2 diabetes; CRC cis rs10791097 0.690 rs12286234 chr11:130730528 T/C cg12179176 chr11:130786555 SNX19 0.69 11.31 0.53 2.9e-25 Autism spectrum disorder or schizophrenia;Schizophrenia; CRC cis rs10193935 0.748 rs11124879 chr2:42697576 C/A cg27598129 chr2:42591480 NA 0.68 7.65 0.39 2.23e-13 Colonoscopy-negative controls vs population controls; CRC cis rs12983728 1.000 rs12983728 chr19:58671267 G/A cg06882758 chr19:58662330 ZNF329 0.73 7.69 0.39 1.71e-13 Cholesterol, total; CRC cis rs992157 0.764 rs3731861 chr2:219191256 T/C cg04880052 chr2:219191631 PNKD -0.44 -6.55 -0.34 2.23e-10 Colorectal cancer; CRC cis rs796364 1.000 rs35594306 chr2:200775125 T/C cg12253985 chr2:200820533 C2orf60;C2orf47 -0.65 -6.32 -0.33 8.69e-10 Schizophrenia; CRC cis rs875971 0.545 rs6970498 chr7:65740895 A/G cg03233332 chr7:66118400 NA -0.42 -5.79 -0.3 1.6e-8 Aortic root size; CRC cis rs10751667 0.714 rs7933889 chr11:972270 C/T ch.11.42038R chr11:967971 AP2A2 0.58 10.01 0.48 9.05e-21 Alzheimer's disease (late onset); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg11140307 chr16:66730384 CMTM4 0.44 6.51 0.34 2.86e-10 Intelligence (multi-trait analysis); CRC cis rs3889199 1.000 rs3889199 chr1:59653742 A/G cg25881383 chr1:59680599 NA -0.37 -6.02 -0.31 4.68e-9 Pulse pressure; CRC cis rs2976388 0.578 rs3758081 chr8:143824373 A/G cg05569086 chr8:143859399 LYNX1 -0.4 -6.25 -0.33 1.27e-9 Urinary tract infection frequency; CRC cis rs3858526 0.584 rs10734559 chr11:5861788 A/C cg13902645 chr11:5959945 NA -0.66 -9.38 -0.46 1.12e-18 DNA methylation (variation); CRC cis rs2929278 0.588 rs688009 chr15:44156302 C/T cg02155558 chr15:43621948 ADAL;LCMT2 0.46 6.33 0.33 7.91e-10 Schizophrenia; CRC cis rs7811142 1.000 rs73161759 chr7:100009994 T/C cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.62 8.15 0.41 7.87e-15 Platelet count; CRC trans rs9329221 0.576 rs1986972 chr8:10268805 C/T cg06636001 chr8:8085503 FLJ10661 0.52 7.83 0.4 6.88e-14 Neuroticism; CRC trans rs1814175 0.616 rs1722020 chr11:49904189 G/A cg03929089 chr4:120376271 NA -0.92 -16.06 -0.66 3.01e-43 Height; CRC cis rs738322 0.554 rs6001033 chr22:38557513 T/A cg25457927 chr22:38595422 NA -0.32 -6.6 -0.34 1.6e-10 Cutaneous nevi; CRC cis rs72781680 1.000 rs7588286 chr2:24071427 A/G cg08917208 chr2:24149416 ATAD2B 0.93 9.54 0.47 3.27e-19 Lymphocyte counts; CRC cis rs5745709 0.861 rs2214825 chr7:81371619 A/G cg18944653 chr7:81381353 HGF -0.3 -5.79 -0.3 1.64e-8 Gout; CRC cis rs908922 0.651 rs4240885 chr1:152529850 G/C cg23254163 chr1:152506842 NA 0.49 9.71 0.47 9.49e-20 Hair morphology; CRC cis rs2228479 0.717 rs2286392 chr16:89809549 A/G cg06558623 chr16:89946397 TCF25 0.85 8.82 0.44 7.03e-17 Skin colour saturation; CRC cis rs28386778 0.897 rs2665844 chr17:61874455 A/G cg23090583 chr17:61904693 PSMC5;FTSJ3 1.05 20.15 0.74 2.13e-59 Prudent dietary pattern; CRC cis rs2404602 0.655 rs4886824 chr15:76969256 A/G cg23625390 chr15:77176239 SCAPER 0.49 7.17 0.37 4.83e-12 Blood metabolite levels; CRC cis rs765787 0.530 rs4514617 chr15:45535439 A/G cg24006582 chr15:45444508 DUOX1 -0.54 -8.41 -0.42 1.26e-15 Uric acid levels; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg17706896 chr19:46406599 MYPOP 0.44 6.63 0.34 1.34e-10 Response to antipsychotic treatment; CRC cis rs887829 0.588 rs4663971 chr2:234674252 C/G cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.48 -7.56 -0.38 4.15e-13 Metabolic traits;Bilirubin levels;Cholelithiasis-related traits in sickle cell anemia;Metabolite levels;Total bilirubin levels in HIV-1 infection;Serum metabolite levels;Blood metabolite levels; CRC cis rs3791556 1.000 rs3791568 chr2:240115701 G/A cg03281426 chr2:240109471 HDAC4 0.62 6.74 0.35 7.01e-11 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs2985684 0.802 rs10150823 chr14:50051751 C/T cg04989706 chr14:50066350 PPIL5 -0.62 -8.8 -0.44 7.77e-17 Carotid intima media thickness; CRC cis rs6546324 0.625 rs4671817 chr2:67866437 T/G cg15745817 chr2:67799979 NA -0.55 -9.54 -0.47 3.34e-19 Endometriosis; CRC cis rs2380220 0.935 rs7744491 chr6:95994980 T/G cg15832292 chr6:96025679 MANEA 0.58 6.02 0.32 4.57e-9 Behavioural disinhibition (generation interaction); CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg27499259 chr13:28400924 NA 0.48 6.18 0.32 1.89e-9 Thyroid stimulating hormone; CRC cis rs1008375 0.966 rs2191504 chr4:17675592 C/G cg16339924 chr4:17578868 LAP3 0.5 6.55 0.34 2.27e-10 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs910316 1.000 rs13099 chr14:75599155 G/A cg03030879 chr14:75389066 RPS6KL1 0.47 7.36 0.38 1.49e-12 Height; CRC cis rs910316 0.934 rs8016330 chr14:75657507 G/T cg08847533 chr14:75593920 NEK9 -0.85 -14.54 -0.63 2.51e-37 Height; CRC cis rs34034915 1 rs34034915 chr6:27720703 T/TG cg08798685 chr6:27730294 NA -0.4 -6.02 -0.32 4.56e-9 Hepatitis A; CRC cis rs10845606 1.000 rs10845610 chr12:12839107 G/A cg04607235 chr12:12878440 APOLD1 -0.57 -5.83 -0.31 1.33e-8 Systemic lupus erythematosus; CRC cis rs10782582 0.609 rs2881785 chr1:76318096 T/C cg10523679 chr1:76189770 ACADM -0.42 -5.91 -0.31 8.53e-9 Daytime sleep phenotypes; CRC cis rs11098499 0.774 rs73842616 chr4:120290683 G/A cg24375607 chr4:120327624 NA 0.48 7.48 0.38 6.72e-13 Corneal astigmatism; CRC cis rs763121 0.853 rs7289577 chr22:39042214 C/G cg06022373 chr22:39101656 GTPBP1 0.78 12.39 0.56 3.54e-29 Menopause (age at onset); CRC cis rs798554 1.000 rs798545 chr7:2762386 C/T cg19346786 chr7:2764209 NA -0.42 -7.63 -0.39 2.57e-13 Height; CRC cis rs8060686 0.545 rs55897859 chr16:68286748 G/C cg26727032 chr16:67993705 SLC12A4 -0.63 -6.45 -0.34 3.95e-10 HDL cholesterol;Metabolic syndrome; CRC cis rs9462027 0.651 rs9469885 chr6:34758716 A/T cg07306190 chr6:34760872 UHRF1BP1 -0.35 -6.23 -0.33 1.4e-9 Systemic lupus erythematosus; CRC cis rs1552244 0.882 rs13099136 chr3:10031431 G/A cg02579736 chr3:10068473 FANCD2;CIDECP 0.93 12.01 0.55 8.67e-28 Alzheimer's disease; CRC trans rs7267979 1.000 rs4815420 chr20:25383979 C/T cg17903999 chr18:56338584 MALT1 0.42 6.97 0.36 1.71e-11 Liver enzyme levels (alkaline phosphatase); CRC cis rs6761276 0.899 rs11693750 chr2:113835602 C/T cg09040174 chr2:113837401 NA 0.65 10.31 0.49 9.07e-22 Protein quantitative trait loci; CRC cis rs72781680 0.898 rs12623079 chr2:24103749 G/A cg08917208 chr2:24149416 ATAD2B 0.88 8.73 0.43 1.32e-16 Lymphocyte counts; CRC cis rs7940866 0.834 rs10894298 chr11:130840571 C/A cg12179176 chr11:130786555 SNX19 0.6 8.63 0.43 2.74e-16 Schizophrenia; CRC cis rs1568889 0.838 rs1525717 chr11:28081205 T/C cg06544937 chr11:28130018 METT5D1;KIF18A 0.92 15.47 0.65 5.89e-41 Bipolar disorder; CRC cis rs10540 1.000 rs12421457 chr11:505780 T/C cg15790184 chr11:494944 RNH1 0.6 6.17 0.32 1.95e-9 Body mass index; CRC cis rs796364 0.865 rs769948 chr2:200728475 C/A cg12253985 chr2:200820533 C2orf60;C2orf47 0.59 6.54 0.34 2.31e-10 Schizophrenia; CRC cis rs7666738 0.606 rs6852813 chr4:99084671 G/A cg05340658 chr4:99064831 C4orf37 0.49 7.21 0.37 3.95e-12 Colonoscopy-negative controls vs population controls; CRC trans rs2303319 0.504 rs12473088 chr2:162485073 A/G cg25193742 chr10:104614220 C10orf32 -0.78 -6.16 -0.32 2.17e-9 Cognitive function; CRC cis rs6456156 1.000 rs6911766 chr6:167523170 T/G cg07513332 chr6:167530253 CCR6 -0.41 -7.24 -0.37 3.29e-12 Primary biliary cholangitis; CRC cis rs67311347 1.000 rs6795475 chr3:40489281 A/G cg09455208 chr3:40491958 NA 0.43 8.74 0.43 1.19e-16 Renal cell carcinoma; CRC cis rs8044995 0.563 rs3785116 chr16:68372730 G/A cg05110241 chr16:68378359 PRMT7 -0.8 -7.84 -0.4 6.29e-14 Schizophrenia; CRC cis rs9400271 0.632 rs9372205 chr6:109588401 A/T cg01475377 chr6:109611718 NA -0.35 -6.09 -0.32 3.18e-9 Sum neutrophil eosinophil counts;Sum basophil neutrophil counts;White blood cell count;Neutrophil count;Myeloid white cell count;Granulocyte count; CRC cis rs2011503 1.000 rs1989867 chr19:19447470 A/G cg11584989 chr19:19387371 SF4 -0.52 -6.13 -0.32 2.55e-9 Bipolar disorder; CRC cis rs853679 0.546 rs200995 chr6:27813694 C/T cg26958806 chr6:27640298 NA -0.67 -5.87 -0.31 1.05e-8 Depression; CRC cis rs10504229 1.000 rs17217047 chr8:58180296 G/A cg22535103 chr8:58192502 C8orf71 -0.82 -12.27 -0.56 9.63e-29 Developmental language disorder (linguistic errors); CRC cis rs9611565 0.512 rs139573 chr22:42214785 G/A cg17554472 chr22:41940697 POLR3H -0.6 -6.07 -0.32 3.54e-9 Vitiligo; CRC cis rs2976388 1.000 rs1045605 chr8:143764101 C/G cg24046110 chr8:143859143 LYNX1 -0.38 -6.61 -0.34 1.58e-10 Urinary tract infection frequency; CRC cis rs172166 0.516 rs2791333 chr6:28111114 A/G cg15786705 chr6:28176104 NA 0.48 7.23 0.37 3.44e-12 Cardiac Troponin-T levels; CRC cis rs9660180 0.967 rs11260623 chr1:1781456 G/T cg03396347 chr1:1875803 NA -0.63 -9.81 -0.48 4.29e-20 Body mass index; CRC cis rs1552244 0.882 rs13089863 chr3:10032259 G/T cg10729496 chr3:10149963 C3orf24 -0.53 -6.69 -0.35 9.38e-11 Alzheimer's disease; CRC cis rs9807989 0.839 rs10192036 chr2:102968211 C/A cg03938978 chr2:103052716 IL18RAP 0.37 6.02 0.32 4.65e-9 Asthma; CRC cis rs8031584 0.706 rs798084 chr15:31126935 C/T cg14829155 chr15:31115871 NA -0.62 -9.75 -0.47 6.71e-20 Huntington's disease progression; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg03592283 chr3:44666723 ZNF197 0.45 7.34 0.38 1.69e-12 Liver disease severity in Alagille syndrome; CRC cis rs600806 0.888 rs3879450 chr1:109909149 C/T cg23032129 chr1:109941072 SORT1 -0.28 -6.01 -0.31 5.02e-9 Intelligence (multi-trait analysis); CRC cis rs7666738 0.830 rs13116691 chr4:98929771 A/C cg05340658 chr4:99064831 C4orf37 0.6 9.35 0.46 1.41e-18 Colonoscopy-negative controls vs population controls; CRC cis rs7666738 0.830 rs11097608 chr4:99011693 T/C cg05340658 chr4:99064831 C4orf37 0.61 9.38 0.46 1.07e-18 Colonoscopy-negative controls vs population controls; CRC cis rs1129187 0.935 rs4987173 chr6:42931224 G/A cg02353165 chr6:42928485 GNMT 0.85 15.74 0.66 5.3e-42 Alzheimer's disease in APOE e4+ carriers; CRC cis rs8180040 1.000 rs553989 chr3:47400328 A/G cg27129171 chr3:47204927 SETD2 -0.65 -10.68 -0.51 4.61e-23 Colorectal cancer; CRC cis rs9520326 1.000 rs1041062 chr13:107867751 C/A cg07094987 chr13:107865374 FAM155A -0.37 -5.8 -0.3 1.57e-8 Obsessive-compulsive symptoms; CRC cis rs216303 0.722 rs216296 chr12:6154670 A/G cg19878637 chr12:6148451 VWF -0.62 -6.59 -0.34 1.71e-10 Low vWF levels; CRC cis rs116095464 0.558 rs73024831 chr5:257192 A/G cg22857025 chr5:266934 NA -1.25 -16.78 -0.68 4.42e-46 Breast cancer; CRC cis rs7666738 0.962 rs17027204 chr4:98997049 G/A cg05340658 chr4:99064831 C4orf37 0.53 7.7 0.39 1.64e-13 Colonoscopy-negative controls vs population controls; CRC cis rs875971 0.830 rs7799834 chr7:65880694 A/C cg18876405 chr7:65276391 NA 0.52 9.04 0.45 1.37e-17 Aortic root size; CRC cis rs1862618 0.671 rs2591966 chr5:56233688 T/G cg20203395 chr5:56204925 C5orf35 0.58 8.23 0.41 4.44e-15 Initial pursuit acceleration; CRC cis rs651907 0.514 rs12636046 chr3:101434448 T/G cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.59 7.98 0.4 2.5e-14 Colorectal cancer; CRC cis rs12541635 0.677 rs2163124 chr8:107058862 G/T cg10147462 chr8:107024639 NA 0.61 11.08 0.52 1.89e-24 Age of smoking initiation; CRC cis rs28386778 0.724 rs35092235 chr17:61944621 T/C cg11494091 chr17:61959527 GH2 0.61 10.23 0.49 1.62e-21 Prudent dietary pattern; CRC cis rs4862750 0.872 rs13110072 chr4:187878524 A/G cg10295955 chr4:187884368 NA -1.03 -26.25 -0.82 1.1e-82 Lobe attachment (rater-scored or self-reported); CRC cis rs7258465 0.897 rs1043327 chr19:18554972 A/G cg01065977 chr19:18549689 ISYNA1 -0.41 -6.4 -0.33 5.49e-10 Breast cancer; CRC trans rs2243480 1.000 rs6958289 chr7:65657111 T/G cg10756647 chr7:56101905 PSPH -0.76 -7.72 -0.39 1.4e-13 Diabetic kidney disease; CRC cis rs593982 0.858 rs663797 chr11:65552740 A/G cg08755490 chr11:65554678 OVOL1 1.2 16.18 0.67 9.88e-44 Atopic dermatitis; CRC cis rs6546550 0.901 rs6741449 chr2:70156589 A/G cg02498382 chr2:70120550 SNRNP27 -0.56 -9.54 -0.47 3.23e-19 Prevalent atrial fibrillation; CRC cis rs2243480 0.901 rs2900904 chr7:65204264 C/G cg25985355 chr7:65971099 NA -0.5 -5.84 -0.31 1.28e-8 Diabetic kidney disease; CRC trans rs17685 0.753 rs10262501 chr7:75668172 G/A cg19862616 chr7:65841803 NCRNA00174 -0.97 -17.53 -0.69 4.67e-49 Coffee consumption;Coffee consumption (cups per day); CRC cis rs7085104 0.632 rs6162 chr10:104596981 G/A cg04362960 chr10:104952993 NT5C2 0.59 8.69 0.43 1.7e-16 Immature fraction of reticulocytes;Schizophrenia; CRC cis rs10499694 0.735 rs2044859 chr7:50612562 A/G cg14593290 chr7:50529359 DDC 0.49 6.96 0.36 1.87e-11 Body mass index; CRC cis rs12822507 0.732 rs4555 chr12:12796872 T/C cg11838227 chr12:12764436 CREBL2 0.41 5.65 0.3 3.54e-8 Systemic lupus erythematosus; CRC cis rs78456975 0.527 rs72778003 chr2:1571487 G/A cg12573674 chr2:1569213 NA -0.81 -10.33 -0.49 7.72e-22 Placebo response in major depressive disorder (% change in symptom score); CRC cis rs28386778 0.897 rs2727290 chr17:61894728 G/T cg07362569 chr17:61921086 SMARCD2 0.38 5.95 0.31 6.87e-9 Prudent dietary pattern; CRC cis rs17253792 0.659 rs34330219 chr14:56017375 G/A cg01858014 chr14:56050164 KTN1 -0.86 -6.64 -0.34 1.27e-10 Putamen volume; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg17274400 chr12:8234945 NECAP1 0.46 5.96 0.31 6.34e-9 Thyroid stimulating hormone; CRC cis rs6743376 0.556 rs6733859 chr2:113819382 C/T cg24553058 chr2:113831203 IL1F10 0.43 6.96 0.36 1.81e-11 Inflammatory biomarkers; CRC cis rs4957048 0.891 rs11960196 chr5:568857 C/A cg16447950 chr5:562315 NA -0.85 -13.05 -0.58 1.17e-31 Ulcerative colitis; CRC cis rs710865 0.519 rs10753518 chr1:19483593 T/C cg13387374 chr1:19411106 UBR4 0.47 7.39 0.38 1.2e-12 Brain structure; CRC cis rs7208859 0.573 rs28779471 chr17:29084369 T/C cg13385521 chr17:29058706 SUZ12P 0.73 8.4 0.42 1.39e-15 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs1577917 0.958 rs12198971 chr6:86525445 G/A cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.49 -6.58 -0.34 1.82e-10 Response to antipsychotic treatment; CRC cis rs9902453 0.904 rs4567782 chr17:28268800 A/C cg26525008 chr17:28256777 EFCAB5;SSH2 0.7 11.54 0.54 4.14e-26 Coffee consumption (cups per day); CRC cis rs9916302 0.904 rs11078898 chr17:37536480 A/G cg03013999 chr17:37608204 MED1 -0.48 -7.51 -0.38 5.54e-13 Glomerular filtration rate (creatinine); CRC cis rs4665809 0.878 rs6720312 chr2:26364934 A/G cg25036284 chr2:26402008 FAM59B 0.48 5.72 0.3 2.37e-8 Gut microbiome composition (summer); CRC cis rs514406 0.929 rs564273 chr1:53332445 G/C cg08859206 chr1:53392774 SCP2 -0.43 -6.9 -0.36 2.68e-11 Monocyte count; CRC cis rs708547 0.624 rs1277284 chr4:57855361 T/G cg25525207 chr4:57843836 C4orf14;POLR2B -0.49 -7.33 -0.37 1.85e-12 Response to bleomycin (chromatid breaks); CRC cis rs11758351 0.660 rs11755943 chr6:26211368 A/G cg10723962 chr6:26240782 HIST1H4F -0.4 -6.54 -0.34 2.36e-10 Gout;Renal underexcretion gout; CRC trans rs7613875 0.663 rs6762477 chr3:50093209 G/A cg21659725 chr3:3221576 CRBN -0.44 -6.43 -0.33 4.47e-10 Body mass index; CRC trans rs73439953 0.592 rs7237384 chr18:56604022 A/G cg04573316 chr19:54216680 MIR519D 0.33 6.14 0.32 2.36e-9 Triptolide cytotoxicity; CRC trans rs17685 0.725 rs4728548 chr7:75654632 A/T cg19862616 chr7:65841803 NCRNA00174 -0.8 -11.31 -0.53 2.77e-25 Coffee consumption;Coffee consumption (cups per day); CRC cis rs12580194 0.593 rs60774348 chr12:55757717 A/G cg23425280 chr12:56401806 NA 0.47 5.78 0.3 1.76e-8 Cancer; CRC trans rs2303319 0.504 rs56026147 chr2:162614089 T/C cg22988483 chr14:93581567 ITPK1 -0.66 -6.07 -0.32 3.52e-9 Cognitive function; CRC cis rs172166 0.637 rs1225592 chr6:28150242 G/A cg15845792 chr6:28175446 NA 0.86 13.37 0.59 7.62e-33 Cardiac Troponin-T levels; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg03433549 chr12:56498817 PA2G4 0.42 6.05 0.32 3.88e-9 Intelligence (multi-trait analysis); CRC cis rs798766 0.830 rs8389 chr4:1746844 A/T cg05874882 chr4:1763078 NA -0.39 -7.3 -0.37 2.22e-12 Bladder cancer;Urinary bladder cancer; CRC cis rs7772486 0.875 rs854148 chr6:146310979 G/C cg13319975 chr6:146136371 FBXO30 -0.39 -5.83 -0.31 1.32e-8 Lobe attachment (rater-scored or self-reported); CRC cis rs8060686 0.841 rs73594554 chr16:67920049 G/A cg19582491 chr16:67682965 RLTPR -0.59 -7.0 -0.36 1.41e-11 HDL cholesterol;Metabolic syndrome; CRC trans rs4618210 0.722 rs1806555 chr3:17016794 G/T cg10765900 chr13:60971006 TDRD3 0.47 5.99 0.31 5.59e-9 Myocardial infarction; CRC cis rs736408 0.546 rs3733046 chr3:52621627 C/T cg11645453 chr3:52864694 ITIH4 0.35 6.22 0.32 1.47e-9 Bipolar disorder; CRC cis rs1179624 0.708 rs35887080 chr7:75260992 T/C cg05145297 chr7:75264568 HIP1 0.56 7.73 0.39 1.28e-13 Age-related nuclear cataracts; CRC cis rs10504229 0.679 rs17800895 chr8:58050085 A/G cg21724239 chr8:58056113 NA 0.75 9.58 0.47 2.38e-19 Developmental language disorder (linguistic errors); CRC cis rs2073499 1.000 rs12629572 chr3:50324672 T/G cg08207895 chr3:50388901 TUSC4;CYB561D2 0.57 6.35 0.33 6.99e-10 Schizophrenia; CRC cis rs12458462 1.000 rs12458462 chr18:77472436 C/A cg11879182 chr18:77439856 CTDP1 0.71 11.14 0.52 1.11e-24 Monocyte count; CRC cis rs4780401 0.609 rs8047190 chr16:11807097 T/C cg01061890 chr16:11836724 TXNDC11 -0.62 -9.16 -0.45 5.58e-18 Rheumatoid arthritis; CRC cis rs9311474 0.569 rs7614981 chr3:52566914 G/T cg07507251 chr3:52567010 NT5DC2 0.62 10.52 0.5 1.66e-22 Electroencephalogram traits; CRC trans rs2303319 0.504 rs961421 chr2:162626099 G/C cg25193742 chr10:104614220 C10orf32 -0.76 -6.46 -0.34 3.66e-10 Cognitive function; CRC cis rs2180341 0.960 rs7745944 chr6:127709574 A/G cg27446573 chr6:127587934 RNF146 0.98 13.76 0.6 2.35e-34 Breast cancer; CRC cis rs4481887 0.927 rs9651177 chr1:248445702 A/G cg13385794 chr1:248469461 NA 0.34 6.13 0.32 2.53e-9 Common traits (Other); CRC cis rs4481887 0.893 rs1339992 chr1:248509182 G/A cg00666640 chr1:248458726 OR2T12 0.49 9.09 0.45 9.72e-18 Common traits (Other); CRC cis rs9649213 0.593 rs6968144 chr7:97915697 G/A cg21770322 chr7:97807741 LMTK2 0.55 9.29 0.46 2.16e-18 Prostate cancer (SNP x SNP interaction); CRC trans rs2303319 0.504 rs55925603 chr2:162497210 G/A cg04269497 chr6:167369491 RNASET2 -0.71 -6.01 -0.31 4.99e-9 Cognitive function; CRC cis rs58804349 0.685 rs11239855 chr10:43483879 A/G cg15903213 chr10:43522190 NA 0.76 6.65 0.34 1.2e-10 Pediatric bone mineral content (radius); CRC cis rs1862618 0.853 rs10461617 chr5:56104308 A/G cg03609598 chr5:56110824 MAP3K1 -0.86 -10.68 -0.51 4.54e-23 Initial pursuit acceleration; CRC cis rs1559088 0.576 rs11084707 chr19:33612873 C/T cg27124370 chr19:33622961 WDR88 0.48 7.12 0.37 6.97e-12 Bone ultrasound measurement (broadband ultrasound attenuation); CRC trans rs11581859 1.000 rs72728530 chr1:99290529 C/T cg12183875 chr3:169587454 LRRC31 0.27 6.21 0.32 1.58e-9 Response to cognitive-behavioural therapy in anxiety disorder; CRC cis rs6500602 0.928 rs3747581 chr16:4462619 A/G cg14951292 chr16:4525986 HMOX2;NMRAL1 0.49 6.96 0.36 1.86e-11 Schizophrenia; CRC cis rs1348850 0.567 rs1527401 chr2:178522104 C/T cg22681709 chr2:178499509 PDE11A -0.44 -8.05 -0.41 1.52e-14 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs4713118 0.615 rs57252182 chr6:27720249 C/A cg15845792 chr6:28175446 NA 0.59 8.34 0.42 2.1e-15 Parkinson's disease; CRC cis rs672059 1.000 rs1760624 chr1:183158552 C/A ch.1.3577855R chr1:183094577 LAMC1 0.5 7.28 0.37 2.41e-12 Hypertriglyceridemia; CRC cis rs514406 0.644 rs7530078 chr1:53204861 G/T cg08859206 chr1:53392774 SCP2 0.41 6.49 0.34 3.21e-10 Monocyte count; CRC cis rs8044868 0.586 rs12917999 chr16:72089451 T/C cg06172871 chr16:72088244 HP 0.43 6.36 0.33 6.92e-10 Body mass index (change over time) in cancer or chronic obstructive pulmonary disease;Body mass index (change over time) in cancer; CRC cis rs17681684 0.565 rs62066034 chr17:9758829 A/G cg26853458 chr17:9805074 RCVRN 0.54 9.45 0.46 6.64e-19 GIP levels in response to oral glucose tolerance test (fasting); CRC cis rs6952808 0.609 rs10230383 chr7:1950113 T/C cg02951883 chr7:2050386 MAD1L1 -0.53 -8.69 -0.43 1.76e-16 Bipolar disorder and schizophrenia; CRC cis rs7851660 0.548 rs1156850 chr9:100573164 G/A cg13688889 chr9:100608707 NA -0.41 -5.82 -0.31 1.4e-8 Strep throat; CRC trans rs9388451 0.626 rs7748729 chr6:126077381 C/T cg05039488 chr6:79577232 IRAK1BP1 -0.73 -12.66 -0.57 3.39e-30 Brugada syndrome; CRC cis rs4713118 0.824 rs9366702 chr6:27734470 T/C cg06470822 chr6:28175283 NA 0.74 9.85 0.48 3.23e-20 Parkinson's disease; CRC cis rs747650 0.504 rs10769227 chr11:47002614 A/T cg19486271 chr11:47235900 DDB2 -0.44 -5.88 -0.31 1.03e-8 Acne (severe); CRC cis rs5750830 0.649 rs5750815 chr22:39798449 T/C cg11247378 chr22:39784982 NA -0.43 -7.63 -0.39 2.54e-13 Intelligence (multi-trait analysis); CRC cis rs9549260 0.564 rs6563844 chr13:41298190 T/C cg21288729 chr13:41239152 FOXO1 0.39 5.92 0.31 8.3e-9 Red blood cell count; CRC cis rs6121246 0.909 rs6060870 chr20:30303299 C/T cg13852791 chr20:30311386 BCL2L1 0.69 11.04 0.52 2.49e-24 Mean corpuscular hemoglobin; CRC trans rs10983614 1.000 rs7867776 chr9:120072627 A/G cg20601730 chr10:7830119 ATP5C1;KIN 0.44 6.3 0.33 9.76e-10 Survival in pancreatic cancer; CRC cis rs10208940 0.920 rs11893513 chr2:68760647 C/T cg12452813 chr2:68675892 NA 0.48 5.99 0.31 5.47e-9 Urate levels in lean individuals; CRC cis rs13191362 0.810 rs35509380 chr6:163053028 A/G cg23758597 chr6:163146217 PARK2 -0.68 -6.78 -0.35 5.72e-11 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs2204008 0.745 rs12146863 chr12:38502346 G/A cg13010199 chr12:38710504 ALG10B 0.48 6.46 0.34 3.84e-10 Bladder cancer; CRC cis rs67311347 1.000 rs28871903 chr3:40511094 T/G cg09455208 chr3:40491958 NA 0.51 9.88 0.48 2.58e-20 Renal cell carcinoma; CRC cis rs11212617 1.000 rs7112136 chr11:108287131 G/A cg12106634 chr11:108092400 ATM;NPAT 0.43 6.51 0.34 2.82e-10 Response to metformin in type 2 diabetes (glycemic); CRC cis rs67478160 0.619 rs11160759 chr14:104231542 C/T cg01849466 chr14:104193079 ZFYVE21 -0.5 -9.0 -0.44 1.84e-17 Schizophrenia; CRC cis rs7811142 1.000 rs28490152 chr7:100020982 G/A cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.02 14.66 0.63 8.58e-38 Platelet count; CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg26618056 chr16:25043323 NA 0.37 6.17 0.32 2.05e-9 Obesity-related traits; CRC cis rs8010715 1.000 rs3742500 chr14:24611978 G/T cg23112188 chr14:24563095 PCK2 -0.36 -6.5 -0.34 3.05e-10 IgG glycosylation; CRC cis rs9325144 0.555 rs61929925 chr12:38698828 C/A cg13010199 chr12:38710504 ALG10B -0.43 -6.16 -0.32 2.12e-9 Morning vs. evening chronotype; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg03257047 chr6:52860152 GSTA4 0.48 6.62 0.34 1.44e-10 Response to antipsychotic treatment; CRC cis rs2455601 0.786 rs56680262 chr11:8971555 C/T cg09997546 chr11:8931473 C11orf17;ST5 -0.52 -7.01 -0.36 1.37e-11 Schizophrenia; CRC cis rs9467773 0.587 rs10946813 chr6:26345141 A/G cg09904177 chr6:26538194 HMGN4 0.47 6.91 0.36 2.48e-11 Intelligence (multi-trait analysis); CRC cis rs60871478 0.679 rs62432240 chr7:794813 A/G cg05535760 chr7:792225 HEATR2 0.98 11.34 0.53 2.19e-25 Cerebrospinal P-tau181p levels; CRC cis rs2228479 0.850 rs1800339 chr16:89839637 C/A cg19635926 chr16:89946313 TCF25 0.62 5.73 0.3 2.3e-8 Skin colour saturation; CRC cis rs73200209 0.744 rs11612907 chr12:116495255 A/G cg01776926 chr12:116560359 MED13L -0.64 -7.69 -0.39 1.72e-13 Total body bone mineral density; CRC cis rs12681287 0.640 rs7830480 chr8:87403137 T/C cg27223183 chr8:87520930 FAM82B 0.53 7.2 0.37 4.05e-12 Caudate activity during reward; CRC cis rs28386778 0.863 rs3760254 chr17:61851751 T/G cg23090583 chr17:61904693 PSMC5;FTSJ3 1.04 20.53 0.75 6.95e-61 Prudent dietary pattern; CRC cis rs4555082 0.874 rs2816626 chr14:105735425 G/A cg18132624 chr14:105716052 BTBD6;BRF1 -0.47 -7.57 -0.39 3.82e-13 Mean platelet volume;Platelet distribution width; CRC cis rs10504229 0.728 rs72650856 chr8:58152695 C/T cg11062466 chr8:58055876 NA 0.45 6.11 0.32 2.74e-9 Developmental language disorder (linguistic errors); CRC cis rs4973397 0.765 rs2290130 chr2:232263127 G/A cg13347044 chr2:232276743 NA 0.45 6.36 0.33 6.61e-10 Anti-saccade response; CRC cis rs6088590 0.931 rs6088624 chr20:33436852 T/A cg24642439 chr20:33292090 TP53INP2 0.56 9.73 0.47 7.74e-20 Coronary artery disease; CRC cis rs9467603 1.000 rs6939997 chr6:25821224 C/T cg08501292 chr6:25962987 TRIM38 1.08 9.37 0.46 1.19e-18 Intelligence (multi-trait analysis); CRC trans rs875971 0.660 rs2191268 chr7:66110224 C/T cg19636311 chr20:16710621 SNRPB2 -0.4 -6.27 -0.33 1.14e-9 Aortic root size; CRC trans rs1814175 0.616 rs10769644 chr11:49987676 C/A cg11707556 chr5:10655725 ANKRD33B -0.52 -10.05 -0.48 6.61e-21 Height; CRC cis rs9595066 1.000 rs66786230 chr13:44711625 T/C cg04068111 chr13:44716778 NA -0.49 -6.28 -0.33 1.09e-9 Schizophrenia; CRC cis rs77972916 0.536 rs7589361 chr2:43589328 C/T cg06169590 chr2:43455088 ZFP36L2;LOC100129726 -0.47 -5.77 -0.3 1.84e-8 Granulocyte percentage of myeloid white cells; CRC cis rs62244186 0.520 rs9311361 chr3:44796132 T/G cg11003573 chr3:44754125 ZNF502 -0.35 -6.13 -0.32 2.5e-9 Depressive symptoms; CRC cis rs6740322 0.895 rs9309098 chr2:43554972 A/C cg06169590 chr2:43455088 ZFP36L2;LOC100129726 0.59 7.3 0.37 2.11e-12 Coronary artery disease; CRC cis rs929354 0.713 rs6946660 chr7:156948648 T/C cg17757837 chr7:157058334 UBE3C 0.74 12.39 0.56 3.31e-29 Body mass index; CRC cis rs10540 1.000 rs61876340 chr11:495699 A/C cg08200582 chr11:442649 ANO9 -0.71 -7.42 -0.38 9.82e-13 Body mass index; CRC cis rs1570884 0.516 rs9316463 chr13:50176844 G/A cg03651054 chr13:50194643 NA 0.36 7.24 0.37 3.1e-12 Sum basophil neutrophil counts;Sum neutrophil eosinophil counts;Neutrophil count;Myeloid white cell count;Granulocyte count; CRC cis rs13118159 0.714 rs6843025 chr4:1334418 C/G cg19318889 chr4:1322082 MAEA 0.5 7.48 0.38 7e-13 Longevity; CRC trans rs9291683 0.610 rs993173 chr4:10323935 T/C cg26043149 chr18:55253948 FECH -0.54 -8.31 -0.42 2.57e-15 Bone mineral density; CRC cis rs34172651 0.617 rs9922436 chr16:24704490 C/G cg06028605 chr16:24865363 SLC5A11 0.43 6.87 0.35 3.13e-11 Intelligence (multi-trait analysis); CRC cis rs7071206 0.947 rs1877998 chr10:79411740 C/T cg07817648 chr10:79422355 NA -0.66 -8.86 -0.44 5.13e-17 Bone mineral density; CRC cis rs6502050 0.799 rs6502066 chr17:80103737 T/C cg13198984 chr17:80129470 CCDC57 0.46 8.16 0.41 6.94e-15 Life satisfaction; CRC cis rs8078723 1.000 rs56922390 chr17:38157021 C/G cg17344932 chr17:38183730 MED24;SNORD124 -0.45 -6.9 -0.36 2.73e-11 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); CRC cis rs4629180 0.586 rs1848699 chr2:102137903 C/G cg04415270 chr2:102091202 RFX8 -0.36 -6.11 -0.32 2.78e-9 Chronic rhinosinusitis with nasal polyps; CRC cis rs9649213 0.593 rs6465662 chr7:97917801 A/T cg00277769 chr7:97922759 BAIAP2L1 -0.61 -10.73 -0.51 3.09e-23 Prostate cancer (SNP x SNP interaction); CRC cis rs1009181 0.585 rs9379827 chr6:26153335 G/T cg00631329 chr6:26305371 NA -0.41 -6.2 -0.32 1.7e-9 Childhood ear infection; CRC cis rs763121 1.000 rs1946990 chr22:38912771 C/T cg06022373 chr22:39101656 GTPBP1 -0.72 -12.0 -0.55 9.33e-28 Menopause (age at onset); CRC cis rs4824093 0.610 rs4824113 chr22:50284974 C/T cg22709217 chr22:50311962 ALG12;CRELD2 -0.97 -8.49 -0.42 7.01e-16 Amyotrophic lateral sclerosis (sporadic); CRC cis rs6951245 0.572 rs75818004 chr7:1047572 C/T cg20603222 chr7:1096387 C7orf50;GPR146 -0.7 -5.73 -0.3 2.26e-8 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs9916302 0.904 rs8079560 chr17:37497661 C/T cg07936489 chr17:37558343 FBXL20 0.85 13.42 0.59 4.61e-33 Glomerular filtration rate (creatinine); CRC trans rs7615952 0.512 rs4234285 chr3:125404477 G/A cg08546805 chr12:8549446 NA -0.4 -6.06 -0.32 3.81e-9 Blood pressure (smoking interaction); CRC trans rs61931739 0.500 rs11052994 chr12:34065843 C/T cg26384229 chr12:38710491 ALG10B 0.54 6.86 0.35 3.41e-11 Morning vs. evening chronotype; CRC cis rs62244186 0.659 rs9873072 chr3:44516496 G/A cg10263370 chr3:44754102 ZNF502 -0.36 -5.98 -0.31 5.86e-9 Depressive symptoms; CRC cis rs367943 0.966 rs348924 chr5:112817930 T/G cg12552261 chr5:112820674 MCC -0.49 -7.66 -0.39 2.06e-13 Type 2 diabetes; CRC cis rs11971779 0.523 rs10234578 chr7:139037988 T/C cg23387468 chr7:139079360 LUC7L2 0.41 6.99 0.36 1.55e-11 Diisocyanate-induced asthma; CRC cis rs561341 0.941 rs72825736 chr17:30330286 G/A cg12193833 chr17:30244370 NA -0.76 -8.88 -0.44 4.33e-17 Hip circumference adjusted for BMI; CRC cis rs4727027 0.933 rs12704062 chr7:148827865 G/A cg23583168 chr7:148888333 NA -0.93 -16.32 -0.67 2.74e-44 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC cis rs1728785 0.681 rs4783647 chr16:68558048 G/A cg02972257 chr16:68554789 NA 0.63 7.27 0.37 2.59e-12 Ulcerative colitis; CRC cis rs1005277 0.579 rs2474588 chr10:38420870 A/G cg00409905 chr10:38381863 ZNF37A -0.66 -11.09 -0.52 1.74e-24 Extrinsic epigenetic age acceleration; CRC cis rs6860806 0.507 rs2631369 chr5:131705266 G/C cg20512303 chr5:131592959 PDLIM4 -0.38 -6.6 -0.34 1.6e-10 Breast cancer; CRC cis rs3785574 0.962 rs4968660 chr17:61792221 G/A cg25654072 chr17:61904446 PSMC5;FTSJ3 0.42 5.86 0.31 1.11e-8 Height; CRC cis rs7552404 0.731 rs11161836 chr1:76354333 C/T cg03433033 chr1:76189801 ACADM 0.72 8.66 0.43 2.09e-16 Blood metabolite levels;Acylcarnitine levels; CRC cis rs780096 0.526 rs780117 chr2:27698343 C/G cg17158414 chr2:27665306 KRTCAP3 -0.3 -6.68 -0.35 9.98e-11 Total body bone mineral density; CRC cis rs1799949 1.000 rs4793212 chr17:41302750 T/C cg25072359 chr17:41440525 NA 0.44 6.42 0.33 4.86e-10 Menopause (age at onset); CRC cis rs748404 0.631 rs560191 chr15:43767774 G/C cg02155558 chr15:43621948 ADAL;LCMT2 0.52 7.47 0.38 7.38e-13 Lung cancer; CRC cis rs11690935 0.959 rs66835971 chr2:172677459 G/A cg13550731 chr2:172543902 DYNC1I2 -1.08 -18.21 -0.71 9.68e-52 Schizophrenia; CRC cis rs6938 0.514 rs35556055 chr15:75253414 G/A cg17294928 chr15:75287854 SCAMP5 0.49 7.02 0.36 1.29e-11 Breast cancer; CRC cis rs10504229 0.683 rs10504224 chr8:58143735 A/G cg22535103 chr8:58192502 C8orf71 -0.74 -8.41 -0.42 1.27e-15 Developmental language disorder (linguistic errors); CRC cis rs11677416 1.000 rs3783555 chr2:113531093 T/C cg27083787 chr2:113543245 IL1A 0.46 6.59 0.34 1.76e-10 Response to antipsychotic treatment in schizophrenia (working memory); CRC cis rs9381040 0.610 rs2268196 chr6:41021950 C/G cg03644281 chr6:41068752 NFYA;LOC221442 0.45 6.49 0.34 3.07e-10 Alzheimer's disease (late onset); CRC cis rs2204008 0.818 rs1589389 chr12:38416041 G/A cg26384229 chr12:38710491 ALG10B -0.65 -9.62 -0.47 1.88e-19 Bladder cancer; CRC cis rs7224685 0.774 rs8081417 chr17:3902650 T/A cg09695851 chr17:3907499 NA 0.74 12.15 0.56 2.55e-28 Type 2 diabetes; CRC cis rs13108904 0.901 rs1680073 chr4:1280337 G/A cg20887711 chr4:1340912 KIAA1530 -0.48 -7.13 -0.37 6.43e-12 Obesity-related traits; CRC cis rs1448094 0.511 rs61930035 chr12:86153695 G/A cg02569458 chr12:86230093 RASSF9 0.51 8.43 0.42 1.13e-15 Major depressive disorder; CRC cis rs9372498 0.536 rs62422227 chr6:118957200 C/G cg15382696 chr6:118971807 C6orf204 0.6 7.53 0.38 5.03e-13 Diastolic blood pressure; CRC cis rs5753618 0.561 rs9606830 chr22:31717799 T/G cg22777020 chr22:31556080 RNF185 0.55 6.33 0.33 7.93e-10 Colorectal cancer; CRC cis rs4076764 1.000 rs4076764 chr1:163441286 A/G cg24596788 chr1:163392923 NA -0.63 -10.13 -0.49 3.5e-21 Motion sickness; CRC cis rs7224685 0.569 rs12947597 chr17:3999199 A/G cg09695851 chr17:3907499 NA -0.48 -6.04 -0.32 4.06e-9 Type 2 diabetes; CRC cis rs6062302 0.522 rs13038448 chr20:62218453 C/T cg16989086 chr20:62203971 PRIC285 0.48 6.22 0.32 1.54e-9 Glioblastoma; CRC cis rs8072100 0.817 rs7213086 chr17:45752310 C/G cg08085267 chr17:45401833 C17orf57 -0.56 -8.6 -0.43 3.41e-16 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs8044995 0.563 rs61746794 chr16:68387457 C/T cg09835421 chr16:68378352 PRMT7 -0.79 -8.09 -0.41 1.2e-14 Schizophrenia; CRC cis rs6951245 0.554 rs10246354 chr7:1132456 C/T cg26224354 chr7:1096374 C7orf50;GPR146 -0.63 -8.45 -0.42 9.26e-16 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs6582630 0.555 rs10880624 chr12:38526316 C/T cg26384229 chr12:38710491 ALG10B 0.71 10.13 0.49 3.74e-21 Drug-induced liver injury (flucloxacillin); CRC cis rs7107174 0.901 rs1055248 chr11:77925573 T/C cg02023728 chr11:77925099 USP35 0.54 8.6 0.43 3.37e-16 Testicular germ cell tumor; CRC cis rs875971 0.862 rs6978028 chr7:65886300 G/C cg18252515 chr7:66147081 NA -0.42 -5.99 -0.31 5.64e-9 Aortic root size; CRC cis rs7833790 1.000 rs7833790 chr8:82731157 T/C cg17211192 chr8:82754475 SNX16 -0.47 -5.97 -0.31 6.16e-9 Diastolic blood pressure; CRC trans rs11814448 1.000 rs12248406 chr10:22319508 A/G cg09300795 chr16:4042428 ADCY9 0.66 6.09 0.32 3.12e-9 Breast cancer; CRC cis rs713477 0.631 rs7145182 chr14:55905231 C/G cg13175173 chr14:55914753 NA -0.41 -7.21 -0.37 3.79e-12 Pediatric bone mineral content (femoral neck); CRC cis rs7932354 0.528 rs12224096 chr11:47174361 C/T cg19486271 chr11:47235900 DDB2 0.44 6.42 0.33 4.79e-10 Bone mineral density (hip);Bone mineral density; CRC cis rs7487075 0.619 rs6582645 chr12:46805144 C/T cg22049899 chr12:47219821 SLC38A4 0.31 5.67 0.3 3.17e-8 Itch intensity from mosquito bite; CRC cis rs7927771 0.832 rs56030824 chr11:47397353 G/A cg05585544 chr11:47624801 NA -0.56 -9.84 -0.48 3.44e-20 Subjective well-being; CRC cis rs6964587 0.967 rs12535601 chr7:91718346 A/G cg17063962 chr7:91808500 NA 0.79 13.94 0.61 4.96e-35 Breast cancer; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg19580880 chr14:21538547 FLJ10357 0.45 6.01 0.31 5.02e-9 Anxiety disorder; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg06646493 chr1:116519019 SLC22A15 -0.38 -6.03 -0.32 4.41e-9 Myopia (pathological); CRC cis rs7613875 0.578 rs2526749 chr3:50076734 A/G cg05623727 chr3:50126028 RBM5 -0.56 -9.67 -0.47 1.28e-19 Body mass index; CRC cis rs853679 0.527 rs853683 chr6:28295039 A/G cg21251018 chr6:28226885 NKAPL 0.52 8.59 0.43 3.61e-16 Depression; CRC cis rs2243480 1.000 rs313814 chr7:65503293 C/A cg18252515 chr7:66147081 NA -1.19 -13.16 -0.59 4.5e-32 Diabetic kidney disease; CRC cis rs9467711 0.651 rs13220395 chr6:26055368 A/G cg16898833 chr6:26189333 HIST1H4D -0.71 -6.16 -0.32 2.13e-9 Autism spectrum disorder or schizophrenia; CRC cis rs1552244 1.000 rs6789156 chr3:10124120 C/T cg02579736 chr3:10068473 FANCD2;CIDECP 0.98 12.82 0.58 8.74e-31 Alzheimer's disease; CRC cis rs2739330 0.828 rs2330635 chr22:24251344 T/C cg24846343 chr22:24311635 DDTL 0.84 14.44 0.62 5.93e-37 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs4713118 0.621 rs9295756 chr6:28033396 G/T cg15845792 chr6:28175446 NA 0.9 11.84 0.55 3.41e-27 Parkinson's disease; CRC cis rs7811142 1.000 rs11761784 chr7:100039970 C/T cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.02 14.75 0.63 3.76e-38 Platelet count; CRC cis rs7937682 0.558 rs7113067 chr11:111692182 G/A cg19812747 chr11:111475976 SIK2 0.44 6.37 0.33 6.53e-10 Primary sclerosing cholangitis; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg21257117 chr11:65029643 POLA2 0.47 6.55 0.34 2.25e-10 Response to antipsychotic treatment; CRC cis rs72781680 1.000 rs72781653 chr2:24215633 T/C cg08917208 chr2:24149416 ATAD2B 0.89 8.97 0.44 2.34e-17 Lymphocyte counts; CRC cis rs9443645 0.901 rs4565265 chr6:79741958 A/G cg11833968 chr6:79620685 NA -0.36 -6.1 -0.32 2.99e-9 Intelligence (multi-trait analysis); CRC cis rs950169 0.545 rs4354897 chr15:84644971 T/C cg24253500 chr15:84953950 NA 0.39 6.06 0.32 3.83e-9 Schizophrenia; CRC cis rs728616 0.717 rs111403425 chr10:81820542 C/T cg11900509 chr10:81946545 ANXA11 -0.53 -5.67 -0.3 3.13e-8 Chronic obstructive pulmonary disease-related biomarkers; CRC trans rs7615952 0.932 rs11922218 chr3:125631289 C/T cg02560186 chr11:3602584 NA -0.46 -6.01 -0.31 4.79e-9 Blood pressure (smoking interaction); CRC trans rs1814175 0.754 rs28663627 chr11:50048829 C/T cg15704280 chr7:45808275 SEPT13 -0.99 -20.32 -0.75 4.54e-60 Height; CRC cis rs12594515 0.967 rs11857628 chr15:45998206 C/T cg19682013 chr15:45996608 NA 0.29 5.9 0.31 8.97e-9 Waist circumference;Weight; CRC cis rs6912958 0.559 rs395358 chr6:88057924 T/C cg04972856 chr6:88032051 C6orf162;GJB7 0.3 5.75 0.3 2.06e-8 Monocyte percentage of white cells; CRC trans rs9583531 0.689 rs9521913 chr13:111382058 C/T cg20064139 chr20:41823021 NA 0.3 6.06 0.32 3.64e-9 Coronary artery disease; CRC cis rs6089584 0.821 rs2273990 chr20:60579149 G/T cg23463467 chr20:60627584 TAF4 0.3 5.63 0.3 3.77e-8 Body mass index; CRC cis rs853679 0.517 rs9357061 chr6:28051772 A/G cg12273811 chr6:28175739 NA 0.71 9.07 0.45 1.08e-17 Depression; CRC cis rs7843479 0.601 rs10866827 chr8:21801141 G/A cg17168535 chr8:21777572 XPO7 0.63 10.77 0.51 2.28e-23 Mean corpuscular volume; CRC cis rs672059 1.000 rs563026 chr1:183161037 A/T ch.1.3577855R chr1:183094577 LAMC1 -0.5 -7.28 -0.37 2.41e-12 Hypertriglyceridemia; CRC cis rs6502050 0.799 rs28376857 chr17:80104351 G/A cg25804541 chr17:80189381 SLC16A3 -0.31 -5.97 -0.31 6.08e-9 Life satisfaction; CRC cis rs9359856 0.518 rs11962279 chr6:90233695 A/C cg13799429 chr6:90582589 CASP8AP2 -0.54 -6.14 -0.32 2.36e-9 Bipolar disorder; CRC cis rs1218582 0.772 rs2335408 chr1:154915977 G/A cg24250549 chr1:154909240 PMVK 0.64 10.85 0.51 1.15e-23 Prostate cancer; CRC cis rs79349575 0.783 rs962272 chr17:46978283 A/G cg22482690 chr17:47019901 SNF8 0.49 8.2 0.41 5.55e-15 Type 2 diabetes; CRC cis rs3820928 1.000 rs10197757 chr2:227763244 A/C cg11843606 chr2:227700838 RHBDD1 -0.39 -5.61 -0.3 4.32e-8 Pulmonary function; CRC cis rs10924970 0.967 rs12030186 chr1:235397477 G/A cg26050004 chr1:235667680 B3GALNT2 0.39 5.78 0.3 1.71e-8 Asthma; CRC cis rs3091242 0.781 rs71652378 chr1:25721457 G/C cg20684491 chr1:25596433 NA 0.43 7.48 0.38 7.03e-13 Erythrocyte sedimentation rate; CRC cis rs780096 0.526 rs1406295 chr2:27689700 A/G cg22903471 chr2:27725779 GCKR -0.37 -6.06 -0.32 3.65e-9 Total body bone mineral density; CRC cis rs10751667 0.666 rs6597958 chr11:978087 C/T cg23136738 chr11:925521 AP2A2 -0.42 -7.09 -0.36 8.19e-12 Alzheimer's disease (late onset); CRC cis rs2455601 0.882 rs10840139 chr11:8894838 T/G cg09997546 chr11:8931473 C11orf17;ST5 -0.52 -6.85 -0.35 3.62e-11 Schizophrenia; CRC cis rs7786808 0.741 rs62479982 chr7:158227546 A/G cg15440763 chr7:158190612 PTPRN2 0.42 6.58 0.34 1.82e-10 Obesity-related traits; CRC cis rs7809950 1.000 rs2107713 chr7:107232369 C/T cg23024343 chr7:107201750 COG5 -0.56 -8.35 -0.42 1.94e-15 Coronary artery disease; CRC cis rs13191362 0.507 rs2846519 chr6:163045463 G/A cg06582575 chr6:163149167 PACRG;PARK2 -0.57 -8.84 -0.44 5.73e-17 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs9322193 0.962 rs4380763 chr6:149999222 A/G cg07701084 chr6:150067640 NUP43 0.56 8.23 0.41 4.42e-15 Lung cancer; CRC cis rs11958404 0.932 rs72816583 chr5:157432647 T/C cg05962755 chr5:157440814 NA 1.01 12.88 0.58 5.12e-31 IgG glycosylation; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg26175033 chr2:43037432 NA 0.37 6.22 0.32 1.53e-9 Liver disease severity in Alagille syndrome; CRC cis rs13108904 0.901 rs6851528 chr4:1296009 G/A cg02018176 chr4:1364513 KIAA1530 0.37 6.12 0.32 2.63e-9 Obesity-related traits; CRC cis rs6735179 0.603 rs10164788 chr2:1753379 G/A cg19300414 chr2:1746591 PXDN 0.44 7.54 0.38 4.73e-13 Response to antipsychotic treatment; CRC cis rs245880 0.740 rs245892 chr7:29191273 T/C cg17163760 chr7:29186267 CPVL -0.39 -6.79 -0.35 5.41e-11 Warfarin maintenance dose; CRC trans rs10242455 0.702 rs917152 chr7:99004497 T/C cg09045935 chr12:6379348 NA 0.98 7.64 0.39 2.42e-13 Blood metabolite levels; CRC cis rs2228479 0.850 rs17226512 chr16:89839976 T/C cg19635926 chr16:89946313 TCF25 0.62 5.73 0.3 2.3e-8 Skin colour saturation; CRC cis rs2576037 0.526 rs4890703 chr18:44522037 A/G cg07643061 chr18:44555308 TCEB3C;TCEB3CL;KATNAL2 -0.39 -6.57 -0.34 1.98e-10 Personality dimensions; CRC cis rs13118159 0.899 rs3796613 chr4:1353321 A/T cg24560729 chr4:1342394 KIAA1530 0.42 7.52 0.38 5.26e-13 Longevity; CRC cis rs9926296 0.712 rs258330 chr16:89729574 T/G cg01097406 chr16:89675127 NA 0.51 9.38 0.46 1.09e-18 Vitiligo; CRC cis rs908922 0.676 rs2181172 chr1:152491794 A/G cg23254163 chr1:152506842 NA 0.5 10.14 0.49 3.42e-21 Hair morphology; CRC cis rs881375 0.935 rs7034390 chr9:123646488 A/T cg14255062 chr9:123606675 PSMD5;LOC253039 0.41 5.98 0.31 5.85e-9 Rheumatoid arthritis; CRC cis rs9457247 0.967 rs428805 chr6:167403132 C/A cg23791538 chr6:167370224 RNASET2 -0.38 -5.94 -0.31 7.32e-9 Crohn's disease; CRC trans rs887829 0.694 rs869283 chr2:234626287 G/A cg14520829 chr3:18390388 SATB1 0.4 6.2 0.32 1.68e-9 Metabolic traits;Bilirubin levels;Cholelithiasis-related traits in sickle cell anemia;Metabolite levels;Total bilirubin levels in HIV-1 infection;Serum metabolite levels;Blood metabolite levels; CRC cis rs875971 0.895 rs7788984 chr7:65915616 A/G cg11764359 chr7:65958608 NA 0.63 9.94 0.48 1.59e-20 Aortic root size; CRC trans rs116095464 0.558 rs7710005 chr5:233572 A/G cg00938859 chr5:1591904 SDHAP3 0.72 7.77 0.39 1.04e-13 Breast cancer; CRC cis rs10751667 0.643 rs7395613 chr11:933873 C/T cg23136738 chr11:925521 AP2A2 -0.41 -6.78 -0.35 5.53e-11 Alzheimer's disease (late onset); CRC cis rs3858526 0.917 rs9284148 chr11:5973185 G/C cg02574844 chr11:5959923 NA -0.46 -6.06 -0.32 3.75e-9 DNA methylation (variation); CRC cis rs3733585 0.673 rs4292333 chr4:9953871 G/A cg00071950 chr4:10020882 SLC2A9 -0.55 -9.74 -0.47 7.09e-20 Cleft plate (environmental tobacco smoke interaction); CRC cis rs3785574 0.962 rs2727331 chr17:61926990 G/T cg22520471 chr17:61851767 DDX42;CCDC47 0.44 5.93 0.31 7.55e-9 Height; CRC cis rs2204008 0.846 rs2030416 chr12:38465118 A/G cg13010199 chr12:38710504 ALG10B -0.48 -6.91 -0.36 2.47e-11 Bladder cancer; CRC cis rs12545109 0.807 rs13263281 chr8:57346582 C/A cg09654669 chr8:57350985 NA -0.44 -6.76 -0.35 6.3e-11 Obesity-related traits; CRC trans rs1814175 0.546 rs1614397 chr11:49913384 G/C cg15704280 chr7:45808275 SEPT13 -0.97 -18.78 -0.72 5.61e-54 Height; CRC cis rs1448094 0.791 rs7303256 chr12:86333217 C/T cg18827107 chr12:86230957 RASSF9 0.42 6.77 0.35 5.93e-11 Major depressive disorder; CRC cis rs7666738 0.791 rs34152299 chr4:98929862 G/C cg17366294 chr4:99064904 C4orf37 0.43 7.32 0.37 1.95e-12 Colonoscopy-negative controls vs population controls; CRC cis rs4824093 0.544 rs73443951 chr22:50301251 C/T cg22709217 chr22:50311962 ALG12;CRELD2 -0.9 -8.71 -0.43 1.47e-16 Amyotrophic lateral sclerosis (sporadic); CRC cis rs7493 0.950 rs17880101 chr7:95031457 A/T cg04155289 chr7:94953770 PON1 -0.61 -7.59 -0.39 3.3e-13 Yu-Zhi constitution type in type 2 diabetes; CRC trans rs853679 0.723 rs9366718 chr6:28205502 A/T cg06606381 chr12:133084897 FBRSL1 -0.65 -6.69 -0.35 9.61e-11 Depression; CRC trans rs944990 0.595 rs10123378 chr9:96375217 C/T cg11478273 chr8:128806682 PVT1 0.42 6.47 0.34 3.52e-10 Body mass index; CRC cis rs7927592 0.763 rs10896326 chr11:68234571 T/C cg01657329 chr11:68192670 LRP5 -0.54 -8.78 -0.44 8.92e-17 Total body bone mineral density; CRC cis rs853679 0.517 rs9468298 chr6:28122345 A/G cg18032046 chr6:28092343 ZSCAN16 -0.51 -5.93 -0.31 7.47e-9 Depression; CRC cis rs57502260 0.573 rs12291008 chr11:68389072 T/C cg01657329 chr11:68192670 LRP5 -0.47 -5.87 -0.31 1.06e-8 Total body bone mineral density (age 45-60); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg08162337 chr19:41223262 ITPKC;ADCK4 0.37 5.96 0.31 6.35e-9 Liver disease severity in Alagille syndrome; CRC trans rs3001167 0.609 rs4603111 chr1:194546369 A/C cg22004422 chr13:113740730 MCF2L -0.6 -6.19 -0.32 1.83e-9 Obesity-related traits; CRC cis rs7666738 0.830 rs7662948 chr4:99020132 G/C cg05340658 chr4:99064831 C4orf37 0.61 9.5 0.46 4.4e-19 Colonoscopy-negative controls vs population controls; CRC cis rs35306767 0.903 rs12249634 chr10:872744 G/A cg20503657 chr10:835505 NA 0.94 11.53 0.54 4.69e-26 Eosinophil percentage of granulocytes; CRC cis rs727505 1.000 rs2402751 chr7:124434760 C/T cg23710748 chr7:124431027 NA -0.87 -14.33 -0.62 1.53e-36 Lewy body disease; CRC cis rs9894429 0.646 rs7406828 chr17:79619226 A/G cg21984481 chr17:79567631 NPLOC4 0.39 6.58 0.34 1.81e-10 Eye color traits; CRC cis rs1008375 1.000 rs28480159 chr4:17685707 A/C cg16339924 chr4:17578868 LAP3 0.53 7.2 0.37 4.23e-12 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs4642101 0.512 rs9813960 chr3:12818205 A/G cg24848339 chr3:12840334 CAND2 0.32 5.92 0.31 7.99e-9 QRS complex (12-leadsum); CRC cis rs4474465 0.790 rs4944206 chr11:78263127 T/C cg27205649 chr11:78285834 NARS2 0.51 6.68 0.35 1.01e-10 Alzheimer's disease (survival time); CRC trans rs2303319 0.504 rs58622044 chr2:162596287 A/G cg14225146 chr17:72744664 SLC9A3R1 -0.68 -6.08 -0.32 3.32e-9 Cognitive function; CRC cis rs10046574 0.831 rs17479687 chr7:135074833 C/G cg27474649 chr7:135195673 CNOT4 0.68 5.6 0.3 4.51e-8 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs10849893 0.557 rs10849890 chr12:121902725 T/C cg01154721 chr12:121881891 KDM2B -0.43 -6.21 -0.32 1.55e-9 Fasting blood glucose;Fasting blood glucose (BMI interaction); CRC cis rs9916302 0.904 rs4795357 chr17:37569551 T/C cg00129232 chr17:37814104 STARD3 -0.55 -8.02 -0.4 1.92e-14 Glomerular filtration rate (creatinine); CRC cis rs7959452 0.868 rs10878967 chr12:69740869 T/C cg20891283 chr12:69753455 YEATS4 0.74 12.17 0.56 2.18e-28 Blood protein levels; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg16116313 chr12:122255002 SETD1B -0.41 -6.39 -0.33 5.82e-10 Liver disease severity in Alagille syndrome; CRC cis rs7589728 0.514 rs78204719 chr2:88460747 G/C cg04511125 chr2:88470314 THNSL2 0.8 8.46 0.42 8.97e-16 Plasma clusterin levels; CRC cis rs1799949 0.930 rs1554063 chr17:41287145 T/C cg07153921 chr17:41440717 NA -0.38 -5.74 -0.3 2.1e-8 Menopause (age at onset); CRC cis rs4713118 0.869 rs9283880 chr6:27715243 A/C cg20933634 chr6:27740509 NA 0.59 8.66 0.43 2.1e-16 Parkinson's disease; CRC cis rs4243830 0.850 rs2063806 chr1:6610382 C/T cg22792644 chr1:6614718 TAS1R1;NOL9 -0.81 -9.88 -0.48 2.55e-20 Body mass index; CRC cis rs7568458 0.846 rs1078004 chr2:85769711 C/G cg02493740 chr2:85810744 VAMP5 -0.38 -6.08 -0.32 3.28e-9 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); CRC cis rs7258465 0.931 rs34053595 chr19:18556749 T/C cg06462663 chr19:18546047 ISYNA1 0.44 6.39 0.33 5.79e-10 Breast cancer; CRC cis rs875971 0.516 rs6945322 chr7:65336056 T/C cg11764359 chr7:65958608 NA 0.51 7.83 0.4 6.7e-14 Aortic root size; CRC cis rs514406 0.861 rs7417821 chr1:53295117 A/G cg25767906 chr1:53392781 SCP2 -0.41 -6.73 -0.35 7.36e-11 Monocyte count; CRC trans rs1814175 0.645 rs1851857 chr11:49855589 A/C cg11707556 chr5:10655725 ANKRD33B -0.51 -9.74 -0.47 7.05e-20 Height; CRC cis rs8077889 0.957 rs17742929 chr17:41891437 C/T cg25876840 chr17:41920477 NA 0.6 8.57 0.43 4.04e-16 Triglycerides; CRC cis rs7487075 0.786 rs2172398 chr12:46672571 A/G cg22049899 chr12:47219821 SLC38A4 0.32 6.12 0.32 2.72e-9 Itch intensity from mosquito bite; CRC cis rs6964587 0.869 rs2023784 chr7:91524677 A/G cg17063962 chr7:91808500 NA -0.74 -12.25 -0.56 1.1e-28 Breast cancer; CRC cis rs713477 0.935 rs4901564 chr14:55912409 G/T cg13175173 chr14:55914753 NA -0.52 -9.79 -0.48 4.94e-20 Pediatric bone mineral content (femoral neck); CRC cis rs751728 1.000 rs3806108 chr6:33767579 C/G cg25922239 chr6:33757077 LEMD2 0.6 9.31 0.46 1.82e-18 Crohn's disease; CRC trans rs2727020 0.702 rs609054 chr11:49219725 C/G cg11707556 chr5:10655725 ANKRD33B 0.36 6.58 0.34 1.81e-10 Coronary artery disease; CRC cis rs10771431 0.597 rs10771412 chr12:9354353 A/C cg22349387 chr12:9600060 DDX12 -0.36 -5.65 -0.3 3.41e-8 Breast size; CRC cis rs425277 0.606 rs451061 chr1:2075068 C/G cg04315214 chr1:2043799 PRKCZ -0.38 -6.74 -0.35 6.91e-11 Height; CRC cis rs11677370 0.561 rs12986995 chr2:3826965 G/A cg17052675 chr2:3827356 NA -0.68 -11.63 -0.54 1.98e-26 Type 2 diabetes; CRC cis rs6504622 0.791 rs61671555 chr17:45037857 C/T cg16759221 chr17:45003025 GOSR2 -0.5 -7.47 -0.38 7.24e-13 Orofacial clefts; CRC trans rs6951245 1.000 rs113575110 chr7:1084394 G/A cg13565492 chr6:43139072 SRF -0.71 -7.25 -0.37 2.95e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg22874627 chr3:31575329 STT3B 0.43 6.02 0.31 4.72e-9 Response to antipsychotic treatment; CRC cis rs3858526 0.523 rs10769290 chr11:5886947 T/A cg05234568 chr11:5960015 NA -0.65 -9.68 -0.47 1.12e-19 DNA methylation (variation); CRC cis rs9326248 0.603 rs7396061 chr11:116750874 A/C cg10398005 chr11:117014888 PAFAH1B2 -0.38 -5.68 -0.3 2.95e-8 Blood protein levels; CRC cis rs2354432 0.607 rs1530336 chr1:146685121 G/A cg25205988 chr1:146714368 CHD1L 1.07 9.25 0.45 2.99e-18 Mitochondrial DNA levels; CRC cis rs2635047 0.604 rs1434527 chr18:44742868 G/T cg19077165 chr18:44547161 KATNAL2 0.4 5.96 0.31 6.37e-9 Educational attainment; CRC cis rs11212617 0.967 rs7127490 chr11:108286758 T/C cg12106634 chr11:108092400 ATM;NPAT 0.39 5.68 0.3 3.01e-8 Response to metformin in type 2 diabetes (glycemic); CRC cis rs9902453 0.691 rs140701 chr17:28538532 C/T cg26525008 chr17:28256777 EFCAB5;SSH2 0.49 7.43 0.38 9.35e-13 Coffee consumption (cups per day); CRC cis rs7623687 0.579 rs78807522 chr3:49056150 C/A cg19401529 chr3:49056140 DALRD3 0.7 7.23 0.37 3.32e-12 Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease);Coronary artery disease; CRC cis rs736408 0.540 rs4687637 chr3:52634092 C/T cg10802521 chr3:52805072 NEK4 -0.56 -8.82 -0.44 6.72e-17 Bipolar disorder; CRC cis rs7224685 0.501 rs781852 chr17:3953102 A/G cg21851534 chr17:3907994 ZZEF1 0.37 6.45 0.33 4.08e-10 Type 2 diabetes; CRC cis rs1559088 0.847 rs3760891 chr19:33599708 C/T cg27124370 chr19:33622961 WDR88 0.44 6.12 0.32 2.64e-9 Bone ultrasound measurement (broadband ultrasound attenuation); CRC cis rs7301826 0.651 rs10744484 chr12:131298506 T/G cg11011512 chr12:131303247 STX2 0.37 5.62 0.3 4.1e-8 Plasma plasminogen activator levels; CRC cis rs6540559 0.673 rs6540564 chr1:210019910 T/C cg21951975 chr1:209979733 IRF6 0.46 5.6 0.3 4.48e-8 Cleft lip with or without cleft palate; CRC trans rs6686842 1.000 rs213734 chr1:41575699 C/T cg19787969 chr8:9763211 NA 0.28 5.97 0.31 6.03e-9 Height; CRC cis rs477895 1.000 rs1047206 chr11:64089216 C/G cg18375707 chr11:64034959 PLCB3 0.48 5.6 0.3 4.49e-8 Mean platelet volume; CRC cis rs7552404 0.731 rs1689275 chr1:76409655 T/C cg03433033 chr1:76189801 ACADM -0.58 -7.18 -0.37 4.7e-12 Blood metabolite levels;Acylcarnitine levels; CRC cis rs6952808 0.635 rs12154473 chr7:1982181 A/G cg02951883 chr7:2050386 MAD1L1 0.62 10.25 0.49 1.36e-21 Bipolar disorder and schizophrenia; CRC cis rs2153535 0.580 rs1855769 chr6:8473095 A/G cg07606381 chr6:8435919 SLC35B3 0.67 10.76 0.51 2.39e-23 Motion sickness; CRC cis rs1008375 0.966 rs2098152 chr4:17684392 G/T cg16339924 chr4:17578868 LAP3 0.53 7.05 0.36 1.06e-11 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs3800461 0.544 rs76990047 chr6:34504042 T/G cg14254433 chr6:34482411 PACSIN1 -0.67 -6.48 -0.34 3.41e-10 Chronic lymphocytic leukemia; CRC cis rs6908034 0.600 rs79733895 chr6:19799541 A/G cg02682789 chr6:19804855 NA 0.81 6.89 0.35 2.9100000000000002e-11 Endometriosis;Deep ovarian and/or rectovaginal disease with dense adhesions; CRC cis rs35110281 0.667 rs4819286 chr21:45120121 G/A cg01579765 chr21:45077557 HSF2BP -0.32 -6.09 -0.32 3.2e-9 Mean corpuscular volume; CRC cis rs798554 0.757 rs1182198 chr7:2862906 C/T cg19717773 chr7:2847554 GNA12 -0.49 -6.86 -0.35 3.46e-11 Height; CRC cis rs7605827 0.930 rs7596435 chr2:15605091 T/C cg19274914 chr2:15703543 NA 0.39 5.95 0.31 6.89e-9 Educational attainment (years of education); CRC cis rs7799006 0.527 rs2159045 chr7:2207401 T/C cg04267008 chr7:1944627 MAD1L1 -0.45 -5.66 -0.3 3.26e-8 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs208520 0.690 rs207077 chr6:66769855 A/C cg07460842 chr6:66804631 NA -1.04 -14.15 -0.62 7.52e-36 Exhaled nitric oxide output; CRC cis rs933688 1.000 rs12651840 chr5:90729592 T/C cg02339078 chr5:90679543 LOC100129716;ARRDC3 0.95 14.84 0.63 1.66e-38 Smoking behavior; CRC cis rs1545257 0.537 rs12988283 chr2:24642086 G/C cg06627628 chr2:24431161 ITSN2 -0.47 -7.0 -0.36 1.46e-11 Sjögren's syndrome; CRC cis rs1552244 0.935 rs28815328 chr3:10062227 G/A cg02579736 chr3:10068473 FANCD2;CIDECP 0.95 12.56 0.57 7.8e-30 Alzheimer's disease; CRC trans rs57221529 0.655 rs11948381 chr5:568413 A/T cg25482853 chr8:67687455 SGK3 0.98 12.1 0.55 3.83e-28 Lung disease severity in cystic fibrosis; CRC cis rs534126 1.000 rs476826 chr7:142906434 C/T cg04182207 chr7:143013161 CLCN1 0.31 5.63 0.3 3.8e-8 Cancer; CRC trans rs916888 0.610 rs199444 chr17:44818276 T/C cg10053473 chr17:62856997 LRRC37A3 -0.65 -8.92 -0.44 3.39e-17 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs2635047 0.638 rs2571010 chr18:44652130 A/G cg19077165 chr18:44547161 KATNAL2 -0.43 -6.66 -0.34 1.17e-10 Educational attainment; CRC cis rs6743376 0.532 rs2251872 chr2:113818632 G/A cg09040174 chr2:113837401 NA 0.44 6.44 0.33 4.3e-10 Inflammatory biomarkers; CRC cis rs6952808 0.656 rs11764212 chr7:2067593 C/A cg22963979 chr7:1858916 MAD1L1 -0.51 -7.13 -0.37 6.4e-12 Bipolar disorder and schizophrenia; CRC cis rs2243480 1.000 rs313832 chr7:65550891 G/T cg18252515 chr7:66147081 NA -1.13 -13.33 -0.59 1.06e-32 Diabetic kidney disease; CRC cis rs7487075 0.619 rs10785629 chr12:46854727 G/A cg22049899 chr12:47219821 SLC38A4 0.31 5.79 0.3 1.62e-8 Itch intensity from mosquito bite; CRC cis rs9368481 0.761 rs9357030 chr6:26985026 G/T cg18278486 chr6:26987575 LOC100270746;C6orf41 -0.52 -8.28 -0.42 3.08e-15 Autism spectrum disorder or schizophrenia; CRC cis rs10911363 0.573 rs2702181 chr1:183516985 T/A cg09173681 chr1:183549694 NCF2 0.79 11.0 0.52 3.61e-24 Systemic lupus erythematosus; CRC cis rs6908034 0.607 rs12526109 chr6:19820089 C/A cg02682789 chr6:19804855 NA 0.85 6.54 0.34 2.32e-10 Endometriosis;Deep ovarian and/or rectovaginal disease with dense adhesions; CRC cis rs354033 0.837 rs60206402 chr7:149189637 G/A cg24335155 chr7:149193227 ZNF746 0.41 6.22 0.32 1.48e-9 Multiple sclerosis; CRC cis rs2228479 0.850 rs17233455 chr16:89816407 A/G cg06656553 chr16:89960601 TCF25 -0.69 -5.74 -0.3 2.15e-8 Skin colour saturation; CRC trans rs7395662 0.500 rs1605360 chr11:48685714 G/A cg21153622 chr11:89784906 NA -0.52 -8.86 -0.44 5.1e-17 HDL cholesterol; CRC cis rs11098499 0.866 rs12513310 chr4:120288039 T/A cg24375607 chr4:120327624 NA 0.48 7.48 0.38 6.72e-13 Corneal astigmatism; CRC trans rs2235573 0.527 rs139884 chr22:38369976 A/G cg19894588 chr14:64061835 NA 0.52 7.26 0.37 2.88e-12 Glioblastoma;Glioma; CRC cis rs2153535 0.580 rs4587214 chr6:8454119 T/C cg07606381 chr6:8435919 SLC35B3 0.68 10.92 0.52 6.84e-24 Motion sickness; CRC cis rs10504229 0.906 rs56138544 chr8:58184558 A/C cg22535103 chr8:58192502 C8orf71 -0.82 -12.27 -0.56 9.63e-29 Developmental language disorder (linguistic errors); CRC cis rs6500395 1.000 rs9938308 chr16:48607229 A/G cg04672837 chr16:48644449 N4BP1 0.45 6.69 0.35 9.58e-11 Response to tocilizumab in rheumatoid arthritis; CRC cis rs4665809 0.877 rs35224700 chr2:26298037 T/C cg27170947 chr2:26402098 FAM59B 0.51 6.11 0.32 2.81e-9 Gut microbiome composition (summer); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg23446514 chr15:66797150 ZWILCH;SNORD18A;RPL4 0.42 6.39 0.33 5.64e-10 Liver disease severity in Alagille syndrome; CRC cis rs3768617 0.510 rs723014 chr1:183076287 A/G ch.1.3577855R chr1:183094577 LAMC1 0.87 15.4 0.65 1.15e-40 Fuchs's corneal dystrophy; CRC cis rs7119 0.717 rs11632729 chr15:77722006 G/A cg17802220 chr15:77601643 NA -0.42 -6.24 -0.33 1.35e-9 Type 2 diabetes; CRC cis rs514406 0.621 rs1930306 chr1:53195686 C/G cg24675658 chr1:53192096 ZYG11B 0.67 10.43 0.5 3.45e-22 Monocyte count; CRC cis rs2625529 0.652 rs8040216 chr15:72255249 C/T cg16672083 chr15:72433130 SENP8 0.47 7.03 0.36 1.23e-11 Red blood cell count; CRC cis rs28386778 0.863 rs2727288 chr17:61901197 T/A cg22520471 chr17:61851767 DDX42;CCDC47 0.75 11.75 0.54 7.35e-27 Prudent dietary pattern; CRC cis rs2011503 1.000 rs8101219 chr19:19643715 G/A cg11584989 chr19:19387371 SF4 0.59 6.53 0.34 2.48e-10 Bipolar disorder; CRC cis rs4242434 0.927 rs7843828 chr8:22463623 C/T cg03733263 chr8:22462867 KIAA1967 1.04 19.99 0.74 9.55e-59 Exploratory eye movement dysfunction in schizophrenia (cognitive search score); CRC cis rs7615952 0.641 rs6805074 chr3:125772274 T/A cg06494592 chr3:125709126 NA -0.56 -6.73 -0.35 7.33e-11 Blood pressure (smoking interaction); CRC cis rs6725806 1.000 rs6725806 chr2:103216172 T/G cg21010569 chr2:103233596 NA 0.44 6.19 0.32 1.82e-9 Blood protein levels; CRC cis rs4713118 0.955 rs9468204 chr6:27688809 C/T cg02683197 chr6:28174875 NA 0.57 7.44 0.38 8.73e-13 Parkinson's disease; CRC cis rs2836974 0.568 rs4816620 chr21:40613786 A/G cg11890956 chr21:40555474 PSMG1 -0.92 -16.25 -0.67 5.28e-44 Cognitive function; CRC cis rs875971 1.000 rs6956179 chr7:65806659 C/T cg12463550 chr7:65579703 CRCP -0.47 -6.78 -0.35 5.75e-11 Aortic root size; CRC trans rs12829704 0.588 rs11045917 chr12:21419948 G/A cg22494081 chr2:11774142 GREB1 0.51 6.06 0.32 3.77e-9 Blood metabolite levels; CRC cis rs68170813 0.559 rs11764448 chr7:106924928 A/G cg02696742 chr7:106810147 HBP1 -0.61 -6.71 -0.35 8.63e-11 Coronary artery disease; CRC cis rs1348850 0.634 rs2293471 chr2:178487729 T/G cg27490568 chr2:178487706 NA 0.51 7.16 0.37 5.18e-12 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs7119 0.651 rs12904823 chr15:77837662 G/A cg10437265 chr15:77819839 NA 0.68 12.16 0.56 2.36e-28 Type 2 diabetes; CRC cis rs11123170 0.529 rs1015753 chr2:113968803 T/G cg21482265 chr2:113992762 PAX8;LOC440839;LOC654433 0.51 6.11 0.32 2.79e-9 Renal function-related traits (BUN); CRC cis rs853679 0.517 rs4713137 chr6:28083521 C/G cg15786705 chr6:28176104 NA 0.76 9.47 0.46 5.57e-19 Depression; CRC cis rs561341 1.000 rs4795669 chr17:30244701 C/T cg19193384 chr17:30244184 NA -0.58 -6.88 -0.35 3.08e-11 Hip circumference adjusted for BMI; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg17544762 chr6:151300474 MTHFD1L 0.5 7.53 0.38 4.86e-13 Liver disease severity in Alagille syndrome; CRC trans rs12478296 0.786 rs6721704 chr2:242994923 A/G cg18288967 chr1:45987694 PRDX1 0.68 7.73 0.39 1.3e-13 Obesity-related traits; CRC cis rs73206853 0.563 rs73194040 chr12:111181106 C/T cg12870014 chr12:110450643 ANKRD13A 0.74 8.71 0.43 1.51e-16 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC trans rs8002861 0.967 rs2166301 chr13:44473955 A/T cg17145862 chr1:211918768 LPGAT1 0.78 15.73 0.66 5.89e-42 Leprosy; CRC cis rs6963495 0.872 rs73190193 chr7:105164852 A/G cg02135003 chr7:105160482 PUS7 -0.91 -12.32 -0.56 6.19e-29 Bipolar disorder (body mass index interaction); CRC cis rs3806843 1.000 rs6891995 chr5:140172008 A/G cg19875535 chr5:140030758 IK 0.6 9.84 0.48 3.35e-20 Depressive symptoms (multi-trait analysis); CRC cis rs2982552 0.844 rs2982559 chr6:152055905 G/A cg22157087 chr6:152012887 ESR1 0.37 5.81 0.3 1.48e-8 Bone properties (heel); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg00862618 chr12:2904096 FKBP4 -0.45 -6.96 -0.36 1.8e-11 Liver disease severity in Alagille syndrome; CRC cis rs4363385 0.818 rs368912 chr1:153016204 C/G cg25856811 chr1:152973957 SPRR3 -0.27 -7.35 -0.38 1.6e-12 Inflammatory skin disease; CRC cis rs2882667 0.858 rs13176497 chr5:138446074 T/C cg09476006 chr5:138032270 NA 0.45 6.92 0.36 2.41e-11 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs929596 0.531 rs2741012 chr2:234508963 C/T cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.42 -5.75 -0.3 2.06e-8 Total bilirubin levels in HIV-1 infection; CRC cis rs11122272 0.735 rs2486743 chr1:231506928 C/G cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.51 -7.66 -0.39 2.06e-13 Hemoglobin concentration; CRC cis rs769267 0.965 rs8101938 chr19:19390497 G/A cg01262667 chr19:19385393 TM6SF2 0.36 5.87 0.31 1.06e-8 Tonsillectomy; CRC cis rs1552244 0.882 rs13088350 chr3:10044626 T/C cg00166722 chr3:10149974 C3orf24 0.61 8.0 0.4 2.17e-14 Alzheimer's disease; CRC cis rs1059312 0.808 rs4760537 chr12:129301299 C/A cg23521905 chr12:129298690 SLC15A4;MGC16384 0.36 6.35 0.33 7.15e-10 Systemic lupus erythematosus; CRC cis rs7044106 0.762 rs10491783 chr9:123450155 C/G cg14255062 chr9:123606675 PSMD5;LOC253039 0.45 6.87 0.35 3.18e-11 Hip circumference adjusted for BMI; CRC cis rs6679356 0.587 rs946685 chr1:67815715 A/G cg24364144 chr1:67875067 SERBP1 0.43 5.71 0.3 2.48e-8 Primary biliary cholangitis; CRC cis rs10782582 0.609 rs1796815 chr1:76396793 T/G cg10523679 chr1:76189770 ACADM -0.42 -5.89 -0.31 9.49e-9 Daytime sleep phenotypes; CRC cis rs7811142 0.830 rs6965458 chr7:99973402 G/A cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.14 15.09 0.64 1.75e-39 Platelet count; CRC cis rs7786808 0.608 rs6978352 chr7:158209802 T/C cg17401720 chr7:158221031 PTPRN2 -0.44 -7.3 -0.37 2.19e-12 Obesity-related traits; CRC cis rs8105895 0.935 rs10420042 chr19:22251926 T/A cg02657401 chr19:22469223 NA -0.34 -5.65 -0.3 3.56e-8 Body mass index (change over time); CRC cis rs34526934 0.608 rs7606110 chr2:177028551 T/C cg09355771 chr2:177043147 NA -0.51 -6.47 -0.34 3.56e-10 Obstructive sleep apnea trait (apnea hypopnea index); CRC cis rs11971779 0.793 rs11772447 chr7:139033589 T/G cg07862535 chr7:139043722 LUC7L2 0.79 10.21 0.49 1.93e-21 Diisocyanate-induced asthma; CRC cis rs60871478 1.000 rs62432242 chr7:797715 G/A cg05535760 chr7:792225 HEATR2 0.77 10.03 0.48 7.97e-21 Cerebrospinal P-tau181p levels; CRC cis rs2243480 1.000 rs464895 chr7:65527106 A/G cg18252515 chr7:66147081 NA -1.15 -12.31 -0.56 6.5e-29 Diabetic kidney disease; CRC cis rs1757171 0.542 rs3818985 chr6:37484214 G/T cg01843034 chr6:37503916 NA -0.4 -7.2 -0.37 4.18e-12 Cognitive performance; CRC cis rs4819052 0.851 rs28622522 chr21:46676599 G/T cg19498844 chr21:46707878 POFUT2;LOC642852 0.78 11.33 0.53 2.35e-25 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg10137990 chr8:145137203 GPAA1 -0.39 -6.06 -0.32 3.81e-9 Myopia (pathological); CRC cis rs6951245 0.935 rs76525951 chr7:1096013 C/T cg07217954 chr7:1067459 C7orf50 0.55 5.72 0.3 2.36e-8 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg15413566 chr7:8301971 ICA1 0.38 6.11 0.32 2.74e-9 Obesity-related traits; CRC cis rs172166 0.694 rs203892 chr6:28067196 T/C cg15845792 chr6:28175446 NA 0.79 11.71 0.54 1.05e-26 Cardiac Troponin-T levels; CRC cis rs6860806 0.507 rs635619 chr5:131720265 G/A cg07395648 chr5:131743802 NA 0.41 5.69 0.3 2.8e-8 Breast cancer; CRC cis rs6831352 0.734 rs3018046 chr4:100030388 C/T cg12011299 chr4:100065546 ADH4 0.45 8.75 0.43 1.11e-16 Alcohol dependence; CRC cis rs947211 0.948 rs863725 chr1:205751196 C/T cg07167872 chr1:205819463 PM20D1 0.43 5.88 0.31 9.87e-9 Parkinson's disease; CRC cis rs28386778 0.897 rs8067102 chr17:61848779 C/G cg06873352 chr17:61820015 STRADA 0.79 14.96 0.64 5.82e-39 Prudent dietary pattern; CRC cis rs7781266 0.790 rs62469963 chr7:133176419 G/A cg03336402 chr7:133662267 EXOC4 0.48 5.71 0.3 2.57e-8 Educational attainment (college completion); CRC cis rs1348850 0.567 rs3770005 chr2:178528874 A/G cg02961200 chr2:178257176 LOC100130691;AGPS 0.59 8.41 0.42 1.25e-15 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs6499255 1.000 rs1139178 chr16:69781468 T/C cg04110750 chr16:69646130 NFAT5 -0.51 -6.75 -0.35 6.86e-11 IgE levels; CRC cis rs12479064 0.724 rs3087403 chr2:100058870 C/T cg14399236 chr2:99771627 LIPT1;TSGA10 -0.58 -7.6 -0.39 3.07e-13 Chronic sinus infection; CRC cis rs6963495 0.818 rs73190156 chr7:105153567 C/T cg13798780 chr7:105162888 PUS7 0.68 8.08 0.41 1.27e-14 Bipolar disorder (body mass index interaction); CRC cis rs28386778 0.897 rs2584639 chr17:61863732 C/T cg22520471 chr17:61851767 DDX42;CCDC47 0.75 11.73 0.54 8.92e-27 Prudent dietary pattern; CRC cis rs12477438 0.798 rs13412764 chr2:99583733 G/A cg14399236 chr2:99771627 LIPT1;TSGA10 -0.7 -9.74 -0.47 7.45e-20 Chronic sinus infection; CRC cis rs8180040 0.726 rs6785790 chr3:47146932 C/T cg27129171 chr3:47204927 SETD2 0.68 11.06 0.52 2.24e-24 Colorectal cancer; CRC cis rs1865760 0.532 rs2006736 chr6:26086017 C/T cg17691542 chr6:26056736 HIST1H1C 0.56 8.51 0.42 6.1e-16 Height; CRC cis rs7524258 0.835 rs7521425 chr1:7306543 C/T cg07173049 chr1:7289937 CAMTA1 0.55 8.84 0.44 6.06e-17 Tourette's syndrome or obsessive-compulsive disorder; CRC cis rs3812762 0.701 rs4929915 chr11:8824418 A/C cg00186954 chr11:8933980 ST5;C11orf17 -0.52 -7.62 -0.39 2.72e-13 Hypospadias; CRC cis rs12541635 0.739 rs7833595 chr8:107089603 G/T cg10147462 chr8:107024639 NA -0.54 -9.45 -0.46 6.71e-19 Age of smoking initiation; CRC cis rs4665809 0.590 rs3806514 chr2:26466772 C/T cg22920501 chr2:26401640 FAM59B 0.85 12.62 0.57 4.71e-30 Gut microbiome composition (summer); CRC cis rs10499694 1.000 rs10499694 chr7:50614173 A/G cg18232548 chr7:50535776 DDC -0.4 -6.13 -0.32 2.47e-9 Body mass index; CRC trans rs4386084 1.000 rs12906877 chr15:50256819 T/C cg02453146 chr1:53068587 GPX7 -0.34 -5.97 -0.31 6.13e-9 Basophil percentage of white cells;Basophil percentage of granulocytes; CRC cis rs7493 1.000 rs12155103 chr7:95037131 G/A cg07404485 chr7:94953653 PON1 -0.45 -6.04 -0.32 4.26e-9 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs4727027 0.704 rs12704083 chr7:148909759 G/A cg23583168 chr7:148888333 NA -0.92 -17.32 -0.69 3.2e-48 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC cis rs11203032 0.831 rs10887927 chr10:90940687 T/C cg16672925 chr10:90967113 CH25H 0.44 5.7 0.3 2.6e-8 Heart failure; CRC cis rs7208859 0.623 rs12103508 chr17:29086781 T/G cg13385521 chr17:29058706 SUZ12P 0.73 8.33 0.42 2.14e-15 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs7209700 0.547 rs884696 chr17:45341244 C/A cg25173405 chr17:45401733 C17orf57 0.47 5.99 0.31 5.65e-9 IgG glycosylation; CRC cis rs728616 0.764 rs56196124 chr10:81902655 A/T cg05935833 chr10:81318306 SFTPA2 -0.56 -6.52 -0.34 2.58e-10 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs9682041 0.597 rs13076319 chr3:170104630 T/G cg11886554 chr3:170076028 SKIL 0.66 8.14 0.41 8.4e-15 Glomerular filtration rate in non diabetics (creatinine);Glomerular filtration rate (creatinine); CRC cis rs10971721 0.749 rs10971741 chr9:33856867 C/G cg13495928 chr9:33750294 PRSS3 0.55 5.93 0.31 7.7e-9 Body mass index; CRC cis rs76793172 0.623 rs10775546 chr19:46267534 C/T cg11657440 chr19:46296263 DMWD 0.57 5.68 0.3 3.01e-8 Eosinophil counts; CRC cis rs589448 0.902 rs2603090 chr12:69777188 G/A cg14784868 chr12:69753453 YEATS4 0.9 17.43 0.69 1.19e-48 Cerebrospinal fluid biomarker levels; CRC cis rs282587 0.502 rs371150 chr13:113397815 C/T cg04656015 chr13:113407548 ATP11A 0.64 8.02 0.4 1.83e-14 Glycated hemoglobin levels; CRC trans rs10875595 0.836 rs2879202 chr5:140668375 G/T cg11712506 chr5:113699683 KCNN2 0.42 5.99 0.31 5.51e-9 Pulmonary function decline; CRC trans rs208515 0.525 rs12193560 chr6:66690457 A/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.94 11.91 0.55 2.03e-27 Exhaled nitric oxide levels; CRC trans rs28735056 0.565 rs12957336 chr18:77716889 A/G cg05926928 chr17:57297772 GDPD1 -0.42 -6.31 -0.33 8.99e-10 Schizophrenia; CRC cis rs9527 0.545 rs11191602 chr10:104954219 C/T cg15744005 chr10:104629667 AS3MT -0.29 -5.76 -0.3 1.92e-8 Arsenic metabolism; CRC cis rs2415984 0.579 rs113349829 chr14:46973973 C/A cg14871534 chr14:47121158 RPL10L -0.39 -5.85 -0.31 1.21e-8 Number of children ever born; CRC cis rs6088813 1.000 rs6088799 chr20:33934301 T/C cg14752227 chr20:34000481 UQCC -0.37 -5.75 -0.3 2.09e-8 Height; CRC cis rs6952809 0.516 rs6952959 chr7:2440722 C/T cg23289794 chr7:2394357 EIF3B -0.79 -9.51 -0.46 4.25e-19 Multiple sclerosis; CRC cis rs3126085 0.935 rs1353436 chr1:152172658 G/A cg09127314 chr1:152161683 NA 0.53 6.87 0.35 3.25e-11 Atopic dermatitis; CRC cis rs2797160 1.000 rs1739363 chr6:126020980 G/A cg05901451 chr6:126070800 HEY2 0.39 6.04 0.32 4.14e-9 Endometrial cancer; CRC cis rs2014572 0.875 rs10405008 chr19:57753643 C/G cg12963866 chr19:57752005 ZNF805 0.4 5.92 0.31 8.11e-9 Hyperactive-impulsive symptoms; CRC cis rs875971 0.545 rs73142245 chr7:65691649 A/G cg03233332 chr7:66118400 NA -0.42 -5.86 -0.31 1.14e-8 Aortic root size; CRC cis rs7580658 0.891 rs55998967 chr2:128048674 A/C cg09760422 chr2:128146352 NA -0.38 -7.43 -0.38 9.45e-13 Protein C levels; CRC cis rs12410462 1.000 rs75637482 chr1:227622944 A/T cg23173402 chr1:227635558 NA 0.71 8.03 0.4 1.71e-14 Major depressive disorder; CRC cis rs477692 0.699 rs557311 chr10:131389484 A/G cg05714579 chr10:131428358 MGMT 0.46 6.55 0.34 2.25e-10 Response to temozolomide; CRC cis rs1005277 0.579 rs2474587 chr10:38420666 C/T cg00409905 chr10:38381863 ZNF37A -0.66 -11.09 -0.52 1.74e-24 Extrinsic epigenetic age acceleration; CRC trans rs9858542 0.953 rs35169793 chr3:49423274 A/G cg21582582 chr3:182698605 DCUN1D1 -0.52 -6.61 -0.34 1.52e-10 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs9549367 0.713 rs3024756 chr13:113822950 G/C cg00898013 chr13:113819073 PROZ -0.55 -7.93 -0.4 3.44e-14 Platelet distribution width; CRC cis rs4780401 0.609 rs8063099 chr16:11806714 T/G cg01061890 chr16:11836724 TXNDC11 -0.62 -9.16 -0.45 5.58e-18 Rheumatoid arthritis; CRC cis rs10752881 1.000 rs12403189 chr1:182983832 G/C ch.1.3577855R chr1:183094577 LAMC1 0.87 15.34 0.65 1.9e-40 Colorectal cancer; CRC cis rs6502050 0.835 rs7219138 chr17:80079896 C/T cg25804541 chr17:80189381 SLC16A3 0.31 6.01 0.31 4.93e-9 Life satisfaction; CRC cis rs1577917 0.687 rs1470531 chr6:86507369 T/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.51 -6.69 -0.35 9.73e-11 Response to antipsychotic treatment; CRC cis rs2404602 0.716 rs7174953 chr15:76906847 A/C cg03037974 chr15:76606532 NA 0.69 12.08 0.55 4.76e-28 Blood metabolite levels; CRC cis rs1707322 0.865 rs785501 chr1:46579611 C/T cg03146154 chr1:46216737 IPP -0.52 -7.15 -0.37 5.72e-12 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs8062405 0.690 rs7187604 chr16:28565953 A/G cg05139728 chr16:28306816 SBK1 -0.37 -5.96 -0.31 6.44e-9 Cognitive ability (multi-trait analysis);Cognitive ability; CRC cis rs6952808 0.689 rs12668156 chr7:2019875 G/A cg00106254 chr7:1943704 MAD1L1 -0.49 -6.98 -0.36 1.6e-11 Bipolar disorder and schizophrenia; CRC cis rs6089584 0.566 rs2146852 chr20:60616492 T/G cg23463467 chr20:60627584 TAF4 0.42 7.87 0.4 5.15e-14 Body mass index; CRC cis rs7927771 1.000 rs4752873 chr11:47857520 C/T cg20307385 chr11:47447363 PSMC3 -0.5 -6.66 -0.34 1.18e-10 Subjective well-being; CRC cis rs7618915 0.547 rs13069481 chr3:52666866 C/T cg07507251 chr3:52567010 NT5DC2 0.42 5.98 0.31 5.97e-9 Bipolar disorder; CRC cis rs3824867 0.920 rs7126210 chr11:47460306 A/G cg05585544 chr11:47624801 NA -0.4 -6.35 -0.33 7.06e-10 Mean corpuscular hemoglobin; CRC cis rs68170813 0.559 rs113211438 chr7:106969198 G/A cg02696742 chr7:106810147 HBP1 -0.57 -6.22 -0.32 1.52e-9 Coronary artery disease; CRC cis rs10751667 0.643 rs7395592 chr11:934094 C/G cg01483505 chr11:975446 AP2A2 0.41 6.59 0.34 1.74e-10 Alzheimer's disease (late onset); CRC trans rs2832077 0.943 rs11700746 chr21:30189207 T/C cg14791747 chr16:20752902 THUMPD1 0.52 6.29 0.33 9.91e-10 Cognitive test performance; CRC cis rs9303401 0.659 rs34818467 chr17:56643109 C/T cg10487724 chr17:56770010 TEX14;RAD51C -0.66 -8.43 -0.42 1.11e-15 Cognitive test performance; CRC cis rs9463078 0.764 rs3799968 chr6:44805377 C/T cg25276700 chr6:44698697 NA -0.26 -6.35 -0.33 7.14e-10 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; CRC cis rs4889855 0.614 rs9898443 chr17:78469357 C/T cg16591659 chr17:78472290 NA 0.55 7.15 0.37 5.69e-12 Fractional excretion of uric acid; CRC cis rs7849270 0.959 rs913275 chr9:131910644 G/A cg13538475 chr9:131942899 NA -0.29 -5.76 -0.3 1.9e-8 Blood metabolite ratios; CRC cis rs2380220 0.541 rs72928277 chr6:96079745 G/T cg23517279 chr6:96025343 MANEA -0.56 -6.2 -0.32 1.64e-9 Behavioural disinhibition (generation interaction); CRC trans rs7819412 0.594 rs7460507 chr8:10969075 C/T cg06636001 chr8:8085503 FLJ10661 -0.59 -8.86 -0.44 5.05e-17 Triglycerides; CRC cis rs10504229 1.000 rs58053450 chr8:58173348 T/C cg22535103 chr8:58192502 C8orf71 -0.82 -12.27 -0.56 9.63e-29 Developmental language disorder (linguistic errors); CRC cis rs6743226 0.901 rs7599888 chr2:242248033 C/G cg10021735 chr2:242295487 FARP2 -0.49 -6.9 -0.36 2.64e-11 Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI in non-smokers; CRC cis rs2882667 0.658 rs10076442 chr5:138276779 T/C cg09476006 chr5:138032270 NA 0.58 10.16 0.49 2.89e-21 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs5753618 0.509 rs5997912 chr22:31593861 A/G cg22777020 chr22:31556080 RNF185 -0.53 -6.2 -0.32 1.72e-9 Colorectal cancer; CRC cis rs644799 0.601 rs568878 chr11:95578694 G/T cg03916912 chr11:95522834 CEP57;FAM76B 0.76 13.09 0.59 8.57e-32 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs4144743 0.528 rs2292866 chr17:45356782 T/C cg18085866 chr17:45331354 ITGB3 -0.59 -6.54 -0.34 2.31e-10 Body mass index; CRC cis rs933688 0.759 rs1423593 chr5:90752351 T/G cg26981201 chr5:90679533 LOC100129716;ARRDC3 0.94 14.49 0.62 3.98e-37 Smoking behavior; CRC trans rs1005277 0.579 rs1740747 chr10:38520465 G/A cg23533926 chr12:111358616 MYL2 -0.56 -8.67 -0.43 2e-16 Extrinsic epigenetic age acceleration; CRC trans rs61931739 0.500 rs11053290 chr12:34582392 C/T cg26384229 chr12:38710491 ALG10B -0.61 -8.95 -0.44 2.57e-17 Morning vs. evening chronotype; CRC cis rs11792861 0.589 rs75742991 chr9:111929624 C/G cg05043794 chr9:111880884 C9orf5 -0.36 -6.57 -0.34 2.02e-10 Menarche (age at onset); CRC cis rs9814567 1.000 rs9813774 chr3:134227100 G/A cg06109529 chr3:134205091 CEP63;ANAPC13 -0.81 -12.26 -0.56 1e-28 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs4731207 0.724 rs2057907 chr7:124443684 G/A cg23710748 chr7:124431027 NA 0.37 5.99 0.31 5.62e-9 Cutaneous malignant melanoma; CRC cis rs875971 0.862 rs1983372 chr7:65611351 C/T cg12463550 chr7:65579703 CRCP -0.52 -7.39 -0.38 1.24e-12 Aortic root size; CRC cis rs7258465 1.000 rs7258465 chr19:18533642 A/G cg10790698 chr19:18539756 SSBP4 -0.46 -8.92 -0.44 3.19e-17 Breast cancer; CRC cis rs2727020 0.729 rs10839283 chr11:49490943 T/C cg27395922 chr11:50257633 LOC441601 0.34 5.85 0.31 1.19e-8 Coronary artery disease; CRC cis rs1707322 1.000 rs1707338 chr1:46511981 T/G cg03146154 chr1:46216737 IPP -0.51 -7.09 -0.36 8.16e-12 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs6496667 1.000 rs6496669 chr15:90895265 A/G cg04176472 chr15:90893244 GABARAPL3 -0.54 -7.96 -0.4 2.88e-14 Rheumatoid arthritis; CRC cis rs10791097 0.703 rs11222360 chr11:130730871 C/T cg12179176 chr11:130786555 SNX19 0.66 10.73 0.51 3.05e-23 Autism spectrum disorder or schizophrenia;Schizophrenia; CRC trans rs7819412 0.875 rs11250121 chr8:11060311 A/C cg06636001 chr8:8085503 FLJ10661 -0.57 -8.7 -0.43 1.63e-16 Triglycerides; CRC cis rs7824557 0.603 rs2250028 chr8:11213589 T/G cg08265495 chr8:11212668 TDH 0.32 5.63 0.3 3.93e-8 Retinal vascular caliber; CRC cis rs950027 0.620 rs1049518 chr15:45653367 G/A cg21132104 chr15:45694354 SPATA5L1 0.42 6.03 0.32 4.3e-9 Response to fenofibrate (adiponectin levels); CRC cis rs9902453 0.904 rs7208579 chr17:28263067 C/G cg26525008 chr17:28256777 EFCAB5;SSH2 0.7 11.54 0.54 4.14e-26 Coffee consumption (cups per day); CRC cis rs1801251 0.752 rs2675966 chr2:233735543 T/C cg25237894 chr2:233734115 C2orf82 -0.63 -11.01 -0.52 3.15e-24 Coronary artery disease; CRC cis rs801193 0.660 rs2659914 chr7:66156914 C/T cg18876405 chr7:65276391 NA 0.5 8.33 0.42 2.28e-15 Aortic root size; CRC cis rs7223966 1.000 rs11657081 chr17:61792339 C/T cg23090583 chr17:61904693 PSMC5;FTSJ3 0.45 5.74 0.3 2.12e-8 Hip circumference adjusted for BMI;Body mass index; CRC cis rs9400271 0.632 rs9398191 chr6:109586561 C/T cg01475377 chr6:109611718 NA -0.34 -5.9 -0.31 8.91e-9 Sum neutrophil eosinophil counts;Sum basophil neutrophil counts;White blood cell count;Neutrophil count;Myeloid white cell count;Granulocyte count; CRC cis rs12530845 0.623 rs7798256 chr7:135344211 C/A cg23117316 chr7:135346802 PL-5283 -0.49 -6.26 -0.33 1.23e-9 Red blood cell traits; CRC cis rs4964805 0.594 rs4964830 chr12:104168908 A/G cg02344784 chr12:104178138 NT5DC3 -0.41 -6.12 -0.32 2.73e-9 Attention deficit hyperactivity disorder; CRC cis rs3733585 0.683 rs13112015 chr4:9933796 C/T cg11266682 chr4:10021025 SLC2A9 -0.52 -10.56 -0.5 1.22e-22 Cleft plate (environmental tobacco smoke interaction); CRC cis rs10464366 0.519 rs6974609 chr7:39219149 C/T cg18850127 chr7:39170497 POU6F2 0.55 7.13 0.37 6.46e-12 IgG glycosylation; CRC cis rs11098499 0.774 rs11098505 chr4:120284627 C/T cg09307838 chr4:120376055 NA 0.68 10.53 0.5 1.51e-22 Corneal astigmatism; CRC cis rs10751667 0.666 rs4072741 chr11:976565 T/C cg23136738 chr11:925521 AP2A2 -0.41 -6.92 -0.36 2.32e-11 Alzheimer's disease (late onset); CRC cis rs7412746 0.563 rs3768013 chr1:150815411 G/A cg15448220 chr1:150897856 SETDB1 0.47 6.67 0.34 1.11e-10 Melanoma; CRC cis rs367615 0.537 rs10463600 chr5:108663636 G/A cg17395555 chr5:108820864 NA 0.39 6.97 0.36 1.76e-11 Colorectal cancer (SNP x SNP interaction); CRC cis rs72627509 0.904 rs56281640 chr4:57765816 G/A cg26694713 chr4:57773883 REST 0.47 5.86 0.31 1.1e-8 Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg25803766 chr8:145150394 CYC1 0.45 6.21 0.32 1.63e-9 Anxiety disorder; CRC cis rs873946 0.517 rs2803990 chr10:134560340 A/G cg06453172 chr10:134556979 INPP5A -0.61 -8.48 -0.42 7.6e-16 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CRC cis rs2933343 0.621 rs789249 chr3:128578453 T/C cg11901034 chr3:128598214 ACAD9 -0.55 -8.07 -0.41 1.36e-14 IgG glycosylation; CRC cis rs9326248 0.813 rs4938350 chr11:117022276 A/G cg11861562 chr11:117069780 TAGLN 0.35 6.42 0.33 4.82e-10 Blood protein levels; CRC cis rs6701037 0.625 rs34270511 chr1:175128543 C/T cg17845761 chr1:175162550 KIAA0040 -0.27 -5.61 -0.3 4.39e-8 Alcohol dependence; CRC cis rs2200578 1.000 rs7566277 chr2:99916242 T/C cg26064155 chr2:99771622 LIPT1;TSGA10 0.52 5.74 0.3 2.13e-8 IgG glycosylation; CRC cis rs6570726 0.577 rs403345 chr6:145845171 T/C cg13319975 chr6:146136371 FBXO30 -0.62 -9.21 -0.45 3.82e-18 Lobe attachment (rater-scored or self-reported); CRC cis rs9733 0.791 rs11800059 chr1:150651175 C/T cg18016565 chr1:150552671 MCL1 -0.43 -6.29 -0.33 9.83e-10 Tonsillectomy; CRC cis rs1816752 0.875 rs1050110 chr13:25009485 C/G cg02811702 chr13:24901961 NA 0.48 6.63 0.34 1.41e-10 Obesity-related traits; CRC cis rs13256369 1.000 rs4840352 chr8:8573508 A/G cg17143192 chr8:8559678 CLDN23 0.48 6.09 0.32 3.11e-9 Obesity-related traits; CRC cis rs12476592 0.602 rs6732791 chr2:63788901 C/A cg10828910 chr2:63850056 LOC388955 0.49 6.11 0.32 2.79e-9 Childhood ear infection; CRC cis rs8005677 0.798 rs35615180 chr14:23404389 T/C cg25600027 chr14:23388339 RBM23 -0.43 -6.34 -0.33 7.59e-10 Cognitive ability (multi-trait analysis); CRC cis rs2439831 0.850 rs12442297 chr15:44168470 C/T cg02155558 chr15:43621948 ADAL;LCMT2 0.68 6.75 0.35 6.62e-11 Lung cancer in ever smokers; CRC trans rs9858542 1.000 rs34762726 chr3:49689210 G/A cg21659725 chr3:3221576 CRBN -0.71 -9.44 -0.46 7.35e-19 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg22805796 chr17:79829393 ARHGDIA 0.42 6.23 0.32 1.41e-9 Intelligence (multi-trait analysis); CRC cis rs40363 0.645 rs1690449 chr16:3520893 C/G cg00484396 chr16:3507460 NAT15 0.57 8.62 0.43 2.84e-16 Tuberculosis; CRC cis rs739496 0.542 rs7399113 chr12:111792848 G/A cg10833066 chr12:111807467 FAM109A 0.56 7.25 0.37 3.06e-12 Platelet count; CRC cis rs7131987 0.845 rs7299861 chr12:29409667 G/A cg09582351 chr12:29534625 ERGIC2 -0.28 -6.01 -0.31 5.06e-9 QT interval; CRC cis rs1707322 1.000 rs3922887 chr1:46473802 A/G cg03146154 chr1:46216737 IPP 0.49 6.85 0.35 3.62e-11 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs7605827 0.930 rs7577512 chr2:15623218 G/T cg19274914 chr2:15703543 NA 0.39 5.95 0.31 6.89e-9 Educational attainment (years of education); CRC cis rs7927771 0.524 rs7933184 chr11:47682402 C/T cg20307385 chr11:47447363 PSMC3 0.46 6.75 0.35 6.82e-11 Subjective well-being; CRC cis rs2067615 0.579 rs12312782 chr12:107135647 G/A cg13491945 chr12:107078410 RFX4 0.35 5.98 0.31 5.87e-9 Heart rate; CRC cis rs73206853 0.841 rs3893403 chr12:111083980 G/A cg12870014 chr12:110450643 ANKRD13A 0.8 8.27 0.41 3.31e-15 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC cis rs3799378 0.582 rs1796518 chr6:26388672 C/T cg09904177 chr6:26538194 HMGN4 -0.45 -5.95 -0.31 6.89e-9 Intelligence (multi-trait analysis); CRC cis rs4713118 0.869 rs9283883 chr6:27715470 T/A cg19041857 chr6:27730383 NA -0.43 -6.07 -0.32 3.49e-9 Parkinson's disease; CRC cis rs9322193 0.607 rs6925151 chr6:150210723 C/T cg07701084 chr6:150067640 NUP43 0.43 5.97 0.31 6.18e-9 Lung cancer; CRC trans rs11039798 0.764 rs12277213 chr11:48782176 G/A cg15704280 chr7:45808275 SEPT13 0.63 6.04 0.32 4.07e-9 Axial length; CRC cis rs9733 0.596 rs7538493 chr1:150655421 T/C cg17724175 chr1:150552817 MCL1 0.58 9.4 0.46 9.25e-19 Tonsillectomy; CRC cis rs7605827 0.930 rs6760888 chr2:15537863 T/C cg19274914 chr2:15703543 NA 0.4 5.94 0.31 7.26e-9 Educational attainment (years of education); CRC cis rs7737355 0.947 rs10041744 chr5:130860852 C/T cg06307176 chr5:131281290 NA 0.42 6.22 0.32 1.54e-9 Life satisfaction; CRC cis rs61897795 0.628 rs174579 chr11:61605613 C/T cg21709803 chr11:61594965 FADS2 -0.45 -5.66 -0.3 3.33e-8 Neutrophil count;Sum basophil neutrophil counts; CRC cis rs875971 0.862 rs778720 chr7:65846275 A/C cg18876405 chr7:65276391 NA -0.5 -8.36 -0.42 1.74e-15 Aortic root size; CRC cis rs3751196 0.803 rs12426526 chr12:104146373 A/G cg02344784 chr12:104178138 NT5DC3 0.67 6.39 0.33 5.83e-10 Sense of smell; CRC cis rs1656402 1.000 rs1071997 chr2:233425541 A/G cg03852847 chr2:233439513 NA 0.45 7.74 0.39 1.27e-13 Non-small cell lung cancer (survival); CRC cis rs2204008 0.627 rs10878488 chr12:38148666 G/A cg13010199 chr12:38710504 ALG10B 0.46 5.82 0.31 1.39e-8 Bladder cancer; CRC cis rs950169 0.580 rs11634322 chr15:85172209 C/T cg11189052 chr15:85197271 WDR73 0.63 9.27 0.46 2.56e-18 Schizophrenia; CRC trans rs7267979 1.000 rs2856 chr20:25433536 T/C cg17903999 chr18:56338584 MALT1 -0.41 -6.88 -0.35 2.94e-11 Liver enzyme levels (alkaline phosphatase); CRC cis rs6963495 0.818 rs6944787 chr7:105147309 C/T cg02135003 chr7:105160482 PUS7 -0.89 -12.26 -0.56 9.87e-29 Bipolar disorder (body mass index interaction); CRC cis rs4713118 0.662 rs469228 chr6:27970704 A/G cg10876282 chr6:28092338 ZSCAN16 0.44 5.88 0.31 9.85e-9 Parkinson's disease; CRC cis rs56283067 0.847 rs12204270 chr6:44697502 A/T cg18551225 chr6:44695536 NA -0.42 -6.14 -0.32 2.41e-9 Total body bone mineral density; CRC cis rs12410462 0.581 rs77837509 chr1:227559873 C/T cg04117972 chr1:227635322 NA 0.65 5.99 0.31 5.38e-9 Major depressive disorder; CRC cis rs4716602 0.596 rs12698432 chr7:156158719 C/G cg16983916 chr7:156159713 NA 0.38 6.74 0.35 7.22e-11 Anti-saccade response; CRC cis rs1448094 0.967 rs10863115 chr12:86332586 T/C cg19622623 chr12:86230825 RASSF9 -0.35 -5.71 -0.3 2.47e-8 Major depressive disorder; CRC cis rs7258465 1.000 rs10425982 chr19:18586519 T/A cg06462663 chr19:18546047 ISYNA1 0.49 7.42 0.38 1.01e-12 Breast cancer; CRC cis rs561341 0.629 rs7216107 chr17:30224419 G/A cg13647721 chr17:30228624 UTP6 0.56 7.25 0.37 2.95e-12 Hip circumference adjusted for BMI; CRC cis rs2290416 0.786 rs60401352 chr8:144673097 G/A cg08017634 chr8:144659831 NAPRT1 0.65 5.78 0.3 1.72e-8 Attention deficit hyperactivity disorder; CRC cis rs7772486 0.701 rs2244308 chr6:146213706 C/T cg23711669 chr6:146136114 FBXO30 0.66 11.24 0.53 4.87e-25 Lobe attachment (rater-scored or self-reported); CRC cis rs7945705 0.967 rs7943377 chr11:8848700 C/T cg12365402 chr11:9010492 NRIP3 0.39 6.09 0.32 3.2e-9 Hemoglobin concentration; CRC cis rs847577 0.674 rs7790479 chr7:97713101 C/G cg21770322 chr7:97807741 LMTK2 0.82 18.06 0.71 3.69e-51 Breast cancer; CRC cis rs17209837 0.607 rs11561963 chr7:87116550 T/A cg00919237 chr7:87102261 ABCB4 -0.5 -6.31 -0.33 9.24e-10 Gallbladder cancer; CRC cis rs2839186 0.771 rs13046451 chr21:47641373 T/A cg13126279 chr21:47581558 C21orf56 0.53 8.6 0.43 3.3e-16 Testicular germ cell tumor; CRC cis rs9733 0.596 rs2275236 chr1:150669952 A/G cg15448220 chr1:150897856 SETDB1 -0.46 -6.52 -0.34 2.57e-10 Tonsillectomy; CRC cis rs780096 0.587 rs6760828 chr2:27579231 T/C cg24768116 chr2:27665128 KRTCAP3 -0.33 -7.42 -0.38 1.03e-12 Total body bone mineral density; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg01185801 chr11:65265397 MALAT1 0.51 6.65 0.34 1.23e-10 Thyroid stimulating hormone; CRC cis rs7552404 0.731 rs5745491 chr1:76350159 T/G cg03433033 chr1:76189801 ACADM -0.68 -8.44 -0.42 1.01e-15 Blood metabolite levels;Acylcarnitine levels; CRC cis rs727505 1.000 rs67939974 chr7:124554364 C/T cg23710748 chr7:124431027 NA -0.85 -14.97 -0.64 5.39e-39 Lewy body disease; CRC cis rs629535 0.665 rs2433331 chr8:70041943 T/C cg26132723 chr8:70041827 NA 0.36 5.92 0.31 7.91e-9 Dupuytren's disease; CRC cis rs832540 0.629 rs10940512 chr5:56082094 G/C cg12311346 chr5:56204834 C5orf35 -0.52 -7.68 -0.39 1.79e-13 Coronary artery disease; CRC cis rs4073416 0.518 rs2184601 chr14:65897368 T/A cg03016385 chr14:66212404 NA -0.42 -5.71 -0.3 2.54e-8 N-glycan levels; CRC cis rs1443512 0.755 rs1373160 chr12:54340383 A/G cg25382128 chr12:54346509 NA -0.39 -5.71 -0.3 2.57e-8 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for BMI in non-smokers;Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction);Waist-hip ratio;Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour); CRC cis rs13082711 0.554 rs1494423 chr3:27375345 A/G cg02860705 chr3:27208620 NA -0.64 -7.98 -0.4 2.42e-14 Systolic blood pressure;Diastolic blood pressure;Blood pressure; CRC cis rs8060686 0.641 rs9674047 chr16:68045046 G/A cg08314208 chr16:67682810 RLTPR -0.49 -5.89 -0.31 9.5e-9 HDL cholesterol;Metabolic syndrome; CRC cis rs892961 0.777 rs747483 chr17:75412091 C/T cg05865280 chr17:75406074 SEPT9 0.62 14.4 0.62 8.72e-37 Airflow obstruction; CRC trans rs7800418 0.723 rs56104401 chr7:26590489 C/G cg14387656 chr2:233470847 EFHD1 0.48 6.58 0.34 1.88e-10 Cognitive function; CRC cis rs4713118 0.527 rs9461433 chr6:28095172 C/T cg21251018 chr6:28226885 NKAPL 0.48 6.33 0.33 7.86e-10 Parkinson's disease; CRC cis rs7264396 0.887 rs224362 chr20:34062642 C/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.4 -6.59 -0.34 1.7e-10 Total cholesterol levels; CRC cis rs4819052 0.851 rs35871601 chr21:46675214 C/T cg19498844 chr21:46707878 POFUT2;LOC642852 0.78 11.28 0.53 3.77e-25 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs4363385 0.818 rs557553 chr1:153010370 T/G cg25856811 chr1:152973957 SPRR3 -0.25 -6.99 -0.36 1.51e-11 Inflammatory skin disease; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg01637218 chr1:29063669 YTHDF2 0.46 6.43 0.33 4.46e-10 Response to antipsychotic treatment; CRC cis rs6860806 0.507 rs2631364 chr5:131706914 C/G cg09877947 chr5:131593287 PDLIM4 -0.45 -7.3 -0.37 2.16e-12 Breast cancer; CRC cis rs539514 0.690 rs528783 chr13:76319460 T/C cg04757411 chr13:76259545 LMO7 -0.36 -6.09 -0.32 3.12e-9 Type 1 diabetes; CRC cis rs6062302 0.522 rs6089929 chr20:62219679 C/T cg09650180 chr20:62225654 GMEB2 -0.51 -6.8 -0.35 4.8e-11 Glioblastoma; CRC trans rs1814175 0.817 rs1794164 chr11:49899610 T/C cg03929089 chr4:120376271 NA -0.94 -17.83 -0.7 3.13e-50 Height; CRC cis rs1008375 0.966 rs2302393 chr4:17654341 G/A cg04450456 chr4:17643702 FAM184B 0.39 6.25 0.33 1.3e-9 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs4862750 0.872 rs6553030 chr4:187899234 T/C cg07414643 chr4:187882934 NA 0.39 6.95 0.36 1.94e-11 Lobe attachment (rater-scored or self-reported); CRC cis rs623323 1.000 rs623323 chr17:700020 A/G cg02666820 chr17:700054 NA 0.44 7.21 0.37 3.76e-12 Type 2 diabetes; CRC cis rs2777491 1.000 rs316605 chr15:41771591 G/A cg18705301 chr15:41695430 NDUFAF1 -0.75 -12.98 -0.58 2.24e-31 Ulcerative colitis; CRC cis rs11212617 0.901 rs2083707 chr11:108066130 A/T cg14761454 chr11:108092087 ATM;NPAT 0.39 5.75 0.3 1.99e-8 Response to metformin in type 2 diabetes (glycemic); CRC cis rs7503807 0.515 rs12946217 chr17:78686566 C/A cg00549398 chr17:78725201 RPTOR 0.43 5.77 0.3 1.87e-8 Obesity; CRC cis rs713587 0.713 rs1982200 chr2:25205427 C/T cg04586622 chr2:25135609 ADCY3 0.36 6.09 0.32 3.16e-9 Body mass index in non-asthmatics; CRC cis rs2479724 0.840 rs10498752 chr6:41768510 T/C cg17623882 chr6:41773611 USP49 0.57 9.65 0.47 1.45e-19 Menarche (age at onset); CRC cis rs1059312 0.522 rs3825181 chr12:129279264 G/A cg21616243 chr12:129299702 MGC16384;SLC15A4 0.51 7.4 0.38 1.15e-12 Systemic lupus erythematosus; CRC cis rs11764590 0.715 rs62444907 chr7:2083267 C/T cg13880726 chr7:1868755 MAD1L1 -0.48 -5.78 -0.3 1.74e-8 Neuroticism; CRC cis rs9611519 0.780 rs1535048 chr22:41684093 C/T cg03806693 chr22:41940476 POLR3H -0.62 -8.33 -0.42 2.22e-15 Neuroticism; CRC cis rs6456156 0.904 rs2023305 chr6:167524898 A/G cg07513332 chr6:167530253 CCR6 0.37 6.53 0.34 2.51e-10 Primary biliary cholangitis; CRC cis rs13191362 1.000 rs34697913 chr6:163000187 T/C cg23758597 chr6:163146217 PARK2 -0.55 -6.12 -0.32 2.61e-9 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs501120 0.584 rs680091 chr10:44738932 G/A cg09554077 chr10:44749378 NA 0.75 8.54 0.43 5.05e-16 Coronary artery disease;Coronary heart disease; CRC cis rs2075165 0.901 rs2025577 chr1:156314104 T/C cg20302342 chr1:156215951 PAQR6 0.37 7.26 0.37 2.9e-12 Tonsillectomy; CRC cis rs7945718 0.621 rs10831896 chr11:12693361 G/A cg25843174 chr11:12811716 TEAD1 0.4 7.47 0.38 7.18e-13 Educational attainment (years of education); CRC cis rs7503807 0.515 rs12948040 chr17:78678434 A/G cg00549398 chr17:78725201 RPTOR 0.43 5.77 0.3 1.86e-8 Obesity; CRC cis rs9517320 1.000 rs9584856 chr13:99126551 G/T cg07423050 chr13:99094983 FARP1 0.4 6.57 0.34 1.92e-10 Longevity; CRC cis rs34779708 0.966 rs2045917 chr10:35418526 G/A cg03585969 chr10:35415529 CREM 0.59 7.83 0.4 6.66e-14 Inflammatory bowel disease;Crohn's disease; CRC cis rs826838 0.900 rs11169301 chr12:39128497 C/A cg13010199 chr12:38710504 ALG10B 0.44 5.68 0.3 3.01e-8 Heart rate; CRC trans rs877282 0.945 rs11253391 chr10:788752 G/A cg22713356 chr15:30763199 NA 1.35 16.39 0.67 1.43e-44 Uric acid levels; CRC cis rs9303280 0.901 rs12950743 chr17:38049233 T/C cg20243544 chr17:37824526 PNMT 0.45 6.82 0.35 4.48e-11 Self-reported allergy; CRC cis rs4713118 0.824 rs9468223 chr6:27740666 C/T cg15845792 chr6:28175446 NA 0.68 8.97 0.44 2.33e-17 Parkinson's disease; CRC cis rs2243480 1.000 rs2420170 chr7:65656053 T/C cg25985355 chr7:65971099 NA 0.54 6.05 0.32 3.85e-9 Diabetic kidney disease; CRC cis rs2842992 0.789 rs7758895 chr6:160193465 T/C cg16489826 chr6:160211363 TCP1;MRPL18 0.49 6.29 0.33 1.02e-9 Age-related macular degeneration (geographic atrophy); CRC cis rs79349575 0.783 rs62075852 chr17:47017176 T/C cg22482690 chr17:47019901 SNF8 0.48 8.01 0.4 2.01e-14 Type 2 diabetes; CRC cis rs79387448 0.745 rs6709719 chr2:103144953 G/A cg09003973 chr2:102972529 NA 0.72 7.85 0.4 5.81e-14 Gut microbiota (bacterial taxa); CRC trans rs2228479 0.850 rs2238531 chr16:89856217 C/G cg24644049 chr4:85504048 CDS1 0.83 7.0 0.36 1.47e-11 Skin colour saturation; CRC cis rs2073300 0.609 rs77673953 chr20:23398794 G/C cg12062639 chr20:23401060 NAPB 0.84 7.63 0.39 2.54e-13 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs4713118 0.513 rs202908 chr6:28011551 C/G cg02683197 chr6:28174875 NA 0.61 8.34 0.42 2.04e-15 Parkinson's disease; CRC cis rs28386778 0.742 rs3020617 chr17:61947303 A/G cg06601766 chr17:61851465 DDX42;CCDC47 0.44 5.88 0.31 1.03e-8 Prudent dietary pattern; CRC cis rs6963495 0.745 rs73190169 chr7:105160500 A/G cg13798780 chr7:105162888 PUS7 0.68 8.08 0.41 1.27e-14 Bipolar disorder (body mass index interaction); CRC cis rs1475911 1.000 rs34421316 chr21:43513989 C/T cg24372256 chr21:43528868 UMODL1;C21orf128 -0.55 -7.28 -0.37 2.44e-12 IgG glycosylation; CRC cis rs7224685 0.501 rs11650023 chr17:4012850 C/T cg09695851 chr17:3907499 NA -0.79 -14.31 -0.62 1.86e-36 Type 2 diabetes; CRC cis rs2737618 0.722 rs2737680 chr1:200088559 C/A cg21825944 chr1:200113062 NR5A2 -0.52 -7.54 -0.38 4.66e-13 Uric acid levels; CRC cis rs12580194 0.593 rs7487419 chr12:55769801 C/G cg19537932 chr12:55886519 OR6C68 -0.71 -9.13 -0.45 6.89e-18 Cancer; CRC cis rs4689388 0.856 rs4308430 chr4:6294095 A/G cg00701064 chr4:6280414 WFS1 0.76 13.28 0.59 1.65e-32 Type 2 diabetes and other traits;Type 2 diabetes; CRC cis rs4654899 0.931 rs4654726 chr1:21203898 A/C cg02927042 chr1:21476669 EIF4G3 0.4 6.48 0.34 3.39e-10 Superior frontal gyrus grey matter volume; CRC cis rs17376456 0.825 rs34592268 chr5:93232751 G/C cg25358565 chr5:93447407 FAM172A 1.06 10.66 0.51 5.35e-23 Diabetic retinopathy; CRC cis rs4713118 0.869 rs6901520 chr6:27714575 G/T cg26587870 chr6:27730563 NA -0.43 -6.71 -0.35 8.63e-11 Parkinson's disease; CRC cis rs10504229 1.000 rs66936919 chr8:58172868 C/G cg02725872 chr8:58115012 NA -0.39 -6.78 -0.35 5.63e-11 Developmental language disorder (linguistic errors); CRC cis rs8077889 0.917 rs72836559 chr17:41913529 C/T cg26893861 chr17:41843967 DUSP3 0.96 12.36 0.56 4.54e-29 Triglycerides; CRC cis rs13108904 0.967 rs2293635 chr4:1291791 A/G cg16405210 chr4:1374714 KIAA1530 -0.44 -5.94 -0.31 7.1e-9 Obesity-related traits; CRC cis rs523522 1.000 rs523522 chr12:121020250 A/T cg12219531 chr12:120966889 COQ5 0.69 9.03 0.45 1.48e-17 High light scatter reticulocyte count; CRC cis rs11105298 0.891 rs10858869 chr12:89857611 C/T cg08166232 chr12:89918718 WDR51B;GALNT4 -0.61 -7.7 -0.39 1.62e-13 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; CRC cis rs1568889 1.000 rs9783281 chr11:28033786 T/C cg06544937 chr11:28130018 METT5D1;KIF18A 0.8 11.29 0.53 3.24e-25 Bipolar disorder; CRC cis rs7584330 0.737 rs1390985 chr2:238367420 G/A cg14458575 chr2:238380390 NA 0.64 11.76 0.54 6.65e-27 Prostate cancer; CRC cis rs3785574 0.962 rs62077512 chr17:61851435 C/T cg11494091 chr17:61959527 GH2 0.38 5.9 0.31 9.09e-9 Height; CRC cis rs9462027 0.651 rs7748203 chr6:34812054 T/C cg07306190 chr6:34760872 UHRF1BP1 -0.34 -6.08 -0.32 3.4e-9 Systemic lupus erythematosus; CRC cis rs763121 0.853 rs3747174 chr22:39069181 T/C cg06544989 chr22:39130855 UNC84B 0.45 6.9 0.36 2.7e-11 Menopause (age at onset); CRC cis rs896854 0.540 rs2011567 chr8:95971920 G/A cg23172400 chr8:95962367 TP53INP1 -0.49 -8.21 -0.41 5.16e-15 Type 2 diabetes; CRC cis rs11792861 0.555 rs4978767 chr9:111762925 C/T cg14432460 chr9:111696404 IKBKAP;C9orf6 0.53 7.45 0.38 8.43e-13 Menarche (age at onset); CRC trans rs11098499 0.866 rs6847778 chr4:120293582 A/G cg25214090 chr10:38739885 LOC399744 0.62 9.91 0.48 2.05e-20 Corneal astigmatism; CRC cis rs7121446 0.555 rs6589903 chr11:121863966 C/T cg13820391 chr11:121835505 NA 0.33 6.05 0.32 4.04e-9 Cardiovascular risk factors (age interaction); CRC cis rs1348850 0.914 rs7587604 chr2:178309848 T/A cg22681709 chr2:178499509 PDE11A -0.37 -6.72 -0.35 8.11e-11 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC trans rs12495832 0.778 rs4681145 chr3:147894103 C/G cg10221266 chr7:153579447 NA 0.56 6.13 0.32 2.54e-9 Chin dimples; CRC cis rs7937682 0.737 rs679032 chr11:111423286 G/T cg19812747 chr11:111475976 SIK2 -0.47 -7.79 -0.39 8.56e-14 Primary sclerosing cholangitis; CRC cis rs6570726 0.577 rs406868 chr6:145809983 C/T cg13319975 chr6:146136371 FBXO30 -0.63 -9.22 -0.45 3.79e-18 Lobe attachment (rater-scored or self-reported); CRC cis rs694739 0.726 rs17857342 chr11:64138905 T/G cg02228329 chr11:64053129 BAD;GPR137 0.48 6.55 0.34 2.17e-10 Alopecia areata;Crohn's disease;Psoriasis vulgaris; CRC cis rs4727027 0.769 rs2140957 chr7:148758885 A/G cg12479418 chr7:148823350 ZNF425;ZNF398 0.42 5.69 0.3 2.83e-8 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC cis rs10779751 0.726 rs1205593 chr1:11252716 T/C cg08854313 chr1:11322531 MTOR 0.59 7.4 0.38 1.13e-12 Body mass index; CRC cis rs28386778 0.897 rs1470697 chr17:61799840 T/C cg11494091 chr17:61959527 GH2 0.61 10.2 0.49 2.05e-21 Prudent dietary pattern; CRC cis rs58804349 0.685 rs9422671 chr10:43288626 T/G cg08461752 chr10:43522343 NA -0.78 -6.03 -0.32 4.48e-9 Pediatric bone mineral content (radius); CRC cis rs1552244 0.572 rs6785976 chr3:10168647 A/G cg08888203 chr3:10149979 C3orf24 0.71 8.63 0.43 2.63e-16 Alzheimer's disease; CRC cis rs2303759 0.709 rs8102574 chr19:49828897 A/G cg22590775 chr19:49891494 CCDC155 0.6 7.79 0.39 8.76e-14 Multiple sclerosis; CRC cis rs9916302 0.706 rs439537 chr17:37734482 T/C cg15445000 chr17:37608096 MED1 0.36 6.14 0.32 2.38e-9 Glomerular filtration rate (creatinine); CRC cis rs2032447 0.899 rs1090947 chr6:26076642 T/C cg18357526 chr6:26021779 HIST1H4A 0.75 11.39 0.53 1.44e-25 Intelligence (multi-trait analysis); CRC cis rs9858542 0.953 rs11713474 chr3:49611457 A/G cg00383909 chr3:49044727 WDR6 0.45 5.66 0.3 3.24e-8 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs8180040 0.903 rs2276854 chr3:47276968 C/T cg02527881 chr3:46936655 PTH1R -0.38 -6.95 -0.36 1.99e-11 Colorectal cancer; CRC cis rs1799949 1.000 rs8176233 chr17:41219804 T/C cg23758822 chr17:41437982 NA 0.81 13.64 0.6 7.09e-34 Menopause (age at onset); CRC cis rs926938 0.563 rs360630 chr1:115415132 C/T cg12756093 chr1:115239321 AMPD1 0.56 8.21 0.41 5.11e-15 Autism; CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg02164492 chr11:46414469 NA -0.42 -6.09 -0.32 3.2e-9 Diisocyanate-induced asthma; CRC cis rs9517320 1.000 rs9645890 chr13:99126637 C/T cg07423050 chr13:99094983 FARP1 0.41 6.57 0.34 1.93e-10 Longevity; CRC cis rs28386778 0.765 rs2070680 chr17:61986988 A/G cg22520471 chr17:61851767 DDX42;CCDC47 -0.63 -9.94 -0.48 1.51e-20 Prudent dietary pattern; CRC cis rs7107174 0.792 rs10751287 chr11:78072476 T/C cg02023728 chr11:77925099 USP35 0.49 8.5 0.42 6.73e-16 Testicular germ cell tumor; CRC cis rs6951245 1.000 rs11763835 chr7:1094513 A/G cg07217954 chr7:1067459 C7orf50 0.56 5.77 0.3 1.86e-8 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs1656402 1.000 rs3108615 chr2:233429700 C/A cg03852847 chr2:233439513 NA 0.44 7.56 0.38 4.08e-13 Non-small cell lung cancer (survival); CRC cis rs877282 1.000 rs7100358 chr10:773681 G/A cg17470449 chr10:769945 NA 0.61 8.85 0.44 5.42e-17 Uric acid levels; CRC cis rs9311676 0.632 rs1126735 chr3:58413408 A/G cg06643156 chr3:58380774 PXK 0.41 6.33 0.33 8.22e-10 Systemic lupus erythematosus; CRC trans rs7824557 0.583 rs2736292 chr8:11234500 A/T cg06636001 chr8:8085503 FLJ10661 0.5 7.63 0.39 2.51e-13 Retinal vascular caliber; CRC cis rs875971 0.660 rs12698534 chr7:65986845 C/T cg11764359 chr7:65958608 NA 0.55 8.6 0.43 3.21e-16 Aortic root size; CRC cis rs796364 0.568 rs11890894 chr2:201072055 C/T cg25936922 chr2:200820526 C2orf60;C2orf47 0.48 5.83 0.31 1.34e-8 Schizophrenia; CRC cis rs2404602 0.735 rs2957614 chr15:76696635 C/T cg23625390 chr15:77176239 SCAPER 0.85 13.79 0.61 1.85e-34 Blood metabolite levels; CRC cis rs11583043 0.874 rs41312668 chr1:101443582 C/T cg16556008 chr1:101360663 SLC30A7;EXTL2 0.44 5.67 0.3 3.07e-8 Ulcerative colitis;Inflammatory bowel disease; CRC cis rs1799949 0.929 rs799905 chr17:41277187 G/C cg05368731 chr17:41323189 NBR1 0.59 8.78 0.44 9.2e-17 Menopause (age at onset); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg25061763 chr12:62860430 MON2 0.42 6.38 0.33 5.98e-10 Intelligence (multi-trait analysis); CRC cis rs7811142 0.943 rs28660238 chr7:100023308 C/T cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.75 10.9 0.52 7.9e-24 Platelet count; CRC cis rs11758351 0.587 rs2050950 chr6:26234883 A/G cg08260959 chr6:26240920 HIST1H4F -0.35 -5.73 -0.3 2.24e-8 Gout;Renal underexcretion gout; CRC cis rs9486719 0.857 rs11759769 chr6:97065212 G/A cg06623918 chr6:96969491 KIAA0776 -0.8 -10.52 -0.5 1.66e-22 Migraine;Coronary artery disease; CRC trans rs561341 0.609 rs2051810 chr17:30195841 C/T cg20587970 chr11:113659929 NA 0.68 8.56 0.43 4.46e-16 Hip circumference adjusted for BMI; CRC cis rs116095464 0.510 rs10057501 chr5:239545 T/C cg22496380 chr5:211416 CCDC127 -0.91 -10.22 -0.49 1.73e-21 Breast cancer; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg23763197 chr11:118965649 H2AFX 0.49 7.18 0.37 4.64e-12 Response to antipsychotic treatment; CRC cis rs4731207 0.698 rs6959712 chr7:124499003 T/A cg23710748 chr7:124431027 NA -0.38 -6.08 -0.32 3.31e-9 Cutaneous malignant melanoma; CRC cis rs4237845 0.537 rs10747787 chr12:58260657 A/G cg00677455 chr12:58241039 CTDSP2 0.74 11.22 0.53 5.81e-25 Intelligence (multi-trait analysis); CRC cis rs7927771 0.965 rs4752881 chr11:47898535 A/G cg18512352 chr11:47633146 NA -0.49 -9.3 -0.46 2.03e-18 Subjective well-being; CRC cis rs1862618 0.802 rs194058 chr5:56188977 G/A cg20203395 chr5:56204925 C5orf35 -0.71 -8.15 -0.41 7.76e-15 Initial pursuit acceleration; CRC cis rs951366 0.617 rs823080 chr1:205789282 G/A cg14893161 chr1:205819251 PM20D1 1.05 20.4 0.75 2.3e-60 Menarche (age at onset); CRC trans rs2243480 0.901 rs3813708 chr7:65305632 C/A cg10756647 chr7:56101905 PSPH 0.71 7.28 0.37 2.5e-12 Diabetic kidney disease; CRC trans rs6472235 0.837 rs7010679 chr8:66935691 A/T cg07884673 chr3:53033167 SFMBT1 -0.45 -6.03 -0.32 4.47e-9 Myopia (pathological);Plateletcrit; CRC cis rs56307353 0.652 rs4807191 chr19:1990309 C/T cg24355006 chr19:1969744 CSNK1G2 -0.49 -8.02 -0.4 1.87e-14 Coronary artery disease; CRC trans rs4843747 0.605 rs28399183 chr16:88107277 G/A cg26811252 chr16:29126840 RRN3P2 0.63 8.58 0.43 3.74e-16 Menopause (age at onset); CRC trans rs9858542 0.953 rs9837027 chr3:49597013 C/T cg21659725 chr3:3221576 CRBN -0.7 -9.69 -0.47 1.06e-19 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs17270561 0.609 rs1892246 chr6:25764408 C/T cg16482183 chr6:26056742 HIST1H1C 0.72 9.1 0.45 8.76e-18 Iron status biomarkers; CRC cis rs12410462 1.000 rs12407171 chr1:227642282 G/A cg04117972 chr1:227635322 NA 0.66 7.49 0.38 6.53e-13 Major depressive disorder; CRC cis rs875971 0.895 rs10755833 chr7:65913917 A/G cg00343986 chr7:65444356 GUSB 0.43 6.29 0.33 1.03e-9 Aortic root size; CRC cis rs6502050 0.871 rs6416857 chr17:80063004 A/G cg13198984 chr17:80129470 CCDC57 -0.46 -7.94 -0.4 3.17e-14 Life satisfaction; CRC cis rs9649213 0.613 rs7777415 chr7:97959214 A/T cg24562669 chr7:97807699 LMTK2 0.44 7.3 0.37 2.17e-12 Prostate cancer (SNP x SNP interaction); CRC cis rs11122272 0.735 rs2739515 chr1:231514681 G/A cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.54 -8.11 -0.41 1.04e-14 Hemoglobin concentration; CRC cis rs938554 0.501 rs7671266 chr4:10056376 C/T cg11266682 chr4:10021025 SLC2A9 -0.42 -6.69 -0.35 9.63e-11 Blood metabolite levels; CRC cis rs6570726 0.791 rs378937 chr6:145834745 C/T cg05347473 chr6:146136440 FBXO30 0.39 6.02 0.31 4.73e-9 Lobe attachment (rater-scored or self-reported); CRC trans rs6703335 0.870 rs10803142 chr1:243598234 A/G cg09332974 chr1:113616366 LRIG2 0.43 6.05 0.32 4e-9 Schizophrenia;Schizophrenia, schizoaffective disorder or bipolar disorder; CRC cis rs3087591 0.708 rs2107359 chr17:29697223 A/T cg24425628 chr17:29625626 OMG;NF1 0.7 12.97 0.58 2.27e-31 Hip circumference; CRC cis rs11203032 0.831 rs4933496 chr10:90952338 T/C cg16672925 chr10:90967113 CH25H 0.45 5.74 0.3 2.17e-8 Heart failure; CRC cis rs1129187 0.755 rs9471988 chr6:42944773 T/C cg26304593 chr6:42947056 PEX6 -0.46 -6.64 -0.34 1.28e-10 Alzheimer's disease in APOE e4+ carriers; CRC cis rs9896052 0.591 rs11077790 chr17:73464718 G/A cg21038819 chr17:73507788 CASKIN2 0.42 6.61 0.34 1.58e-10 Sight-threatening diabetic retinopathy in type 2 diabetes; CRC cis rs9303401 0.614 rs34550282 chr17:57092788 G/A cg10487724 chr17:56770010 TEX14;RAD51C 0.71 8.91 0.44 3.45e-17 Cognitive test performance; CRC cis rs7811142 0.830 rs3087502 chr7:99955364 G/A cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.73 9.99 0.48 1.07e-20 Platelet count; CRC cis rs992157 0.710 rs12996912 chr2:219110555 A/G cg04731861 chr2:219085781 ARPC2 -0.32 -6.75 -0.35 6.64e-11 Colorectal cancer; CRC cis rs4713118 0.662 rs9468271 chr6:28024570 A/G cg12273811 chr6:28175739 NA 0.63 8.44 0.42 9.98e-16 Parkinson's disease; CRC cis rs589448 0.535 rs12423794 chr12:69713018 G/A cg20891283 chr12:69753455 YEATS4 0.8 13.33 0.59 1.07e-32 Cerebrospinal fluid biomarker levels; CRC cis rs1322512 1.000 rs1744369 chr6:152946531 T/A cg03415253 chr6:152958462 SYNE1 -0.41 -6.37 -0.33 6.5e-10 Tonometry; CRC cis rs12760731 0.720 rs34194793 chr1:178329065 G/T cg00404053 chr1:178313656 RASAL2 0.94 9.89 0.48 2.37e-20 Obesity-related traits; CRC cis rs7833790 1.000 rs28696138 chr8:82770794 G/A cg17211192 chr8:82754475 SNX16 0.56 6.79 0.35 5.1e-11 Diastolic blood pressure; CRC cis rs9905704 0.846 rs302878 chr17:56762964 G/A cg12560992 chr17:57184187 TRIM37 0.57 8.25 0.41 3.82e-15 Testicular germ cell tumor; CRC cis rs10751667 0.643 rs11246348 chr11:939476 G/C cg01483505 chr11:975446 AP2A2 0.42 6.71 0.35 8.38e-11 Alzheimer's disease (late onset); CRC cis rs4713118 0.955 rs9368529 chr6:27684631 G/A cg25164649 chr6:28176230 NA 0.53 7.14 0.37 6.07e-12 Parkinson's disease; CRC cis rs17713451 0.593 rs28764001 chr7:151269426 C/G cg18404559 chr7:151322523 PRKAG2 -0.57 -6.41 -0.33 5.12e-10 Interleukin-4 levels; CRC cis rs7618501 0.699 rs2681781 chr3:49898273 A/G cg05623727 chr3:50126028 RBM5 0.45 7.23 0.37 3.47e-12 Intelligence (multi-trait analysis); CRC cis rs9359856 0.564 rs36040566 chr6:90372574 A/C cg13799429 chr6:90582589 CASP8AP2 -0.73 -7.32 -0.37 1.89e-12 Bipolar disorder; CRC trans rs56176327 0.600 rs7628207 chr3:49754970 T/C cg21659725 chr3:3221576 CRBN -0.66 -7.53 -0.38 4.98e-13 Intelligence (multi-trait analysis); CRC cis rs427941 0.703 rs201458 chr7:101741439 T/C cg06246474 chr7:101738831 CUX1 0.46 7.24 0.37 3.2e-12 Plasma omega-3 polyunsaturated fatty acid level (eicosapentaenoic acid); CRC cis rs250677 0.687 rs185155 chr5:148455893 T/C cg23229984 chr5:148520753 ABLIM3 0.49 6.51 0.34 2.83e-10 Breast cancer; CRC cis rs6546324 0.580 rs6724133 chr2:67858671 A/G cg15745817 chr2:67799979 NA -0.57 -9.68 -0.47 1.16e-19 Endometriosis; CRC cis rs4713118 0.513 rs149954 chr6:28035246 G/A cg18032046 chr6:28092343 ZSCAN16 -0.42 -5.7 -0.3 2.6e-8 Parkinson's disease; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg14441964 chr10:75910358 ADK;AP3M1 0.39 5.98 0.31 5.9e-9 Intelligence (multi-trait analysis); CRC cis rs2481665 0.902 rs1013293 chr1:62570321 G/A cg18591186 chr1:62594603 INADL -0.61 -8.93 -0.44 3.16e-17 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs832540 0.864 rs252908 chr5:56120686 T/C cg18230493 chr5:56204884 C5orf35 -0.41 -6.17 -0.32 2.05e-9 Coronary artery disease; CRC cis rs13191362 0.935 rs73008456 chr6:163013697 G/A cg06582575 chr6:163149167 PACRG;PARK2 0.75 10.24 0.49 1.58e-21 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs9443645 0.901 rs9343843 chr6:79585625 C/T cg05283184 chr6:79620031 NA -0.58 -9.37 -0.46 1.21e-18 Intelligence (multi-trait analysis); CRC cis rs853679 0.517 rs1904841 chr6:28108085 C/T cg06470822 chr6:28175283 NA 1.0 13.22 0.59 2.69e-32 Depression; CRC cis rs763014 0.966 rs12935215 chr16:670605 T/C cg00802000 chr16:706648 WDR90 -0.44 -6.35 -0.33 7.31e-10 Height; CRC cis rs741668 0.931 rs4417456 chr13:46588408 T/C cg06018095 chr13:46550134 ZC3H13 0.41 5.73 0.3 2.21e-8 Cerebrospinal fluid clusterin levels; CRC cis rs600231 0.508 rs34582634 chr11:65220206 G/A cg17120908 chr11:65337727 SSSCA1 -0.71 -7.74 -0.39 1.27e-13 Bone mineral density; CRC cis rs7727544 0.716 rs4705926 chr5:131561758 C/T cg18758796 chr5:131593413 PDLIM4 0.34 6.16 0.32 2.14e-9 Blood metabolite levels; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg22468868 chr17:58042029 RNFT1 0.5 6.94 0.36 2.07e-11 Anxiety disorder; CRC cis rs7927771 0.832 rs11039212 chr11:47393303 A/T cg05585544 chr11:47624801 NA 0.5 8.9 0.44 3.78e-17 Subjective well-being; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg07355262 chr7:5347698 TNRC18 -0.32 -6.02 -0.31 4.59e-9 Liver disease severity in Alagille syndrome; CRC cis rs853679 1.000 rs735765 chr6:28170297 G/A cg02683197 chr6:28174875 NA 0.67 6.22 0.32 1.53e-9 Depression; CRC cis rs60871478 0.592 rs4275123 chr7:857352 A/G cg05535760 chr7:792225 HEATR2 -0.64 -7.59 -0.39 3.39e-13 Cerebrospinal P-tau181p levels; CRC cis rs514406 0.565 rs897732 chr1:53382816 A/C cg27535305 chr1:53392650 SCP2 -0.45 -7.98 -0.4 2.52e-14 Monocyte count; CRC cis rs875971 0.862 rs10276077 chr7:65728411 A/G cg18252515 chr7:66147081 NA 0.4 5.73 0.3 2.28e-8 Aortic root size; CRC cis rs2836974 0.863 rs8132333 chr21:40527900 A/G cg17971929 chr21:40555470 PSMG1 0.84 12.82 0.58 8.77e-31 Cognitive function; CRC cis rs10486722 0.607 rs6463038 chr7:41768105 G/A cg22138096 chr7:41772439 LOC285954 0.55 7.02 0.36 1.31e-11 Pit-and-Fissure caries; CRC cis rs10924970 1.000 rs4660114 chr1:235328341 G/A cg26050004 chr1:235667680 B3GALNT2 0.4 5.97 0.31 6.04e-9 Asthma; CRC trans rs11343 0.675 rs7359333 chr16:19262344 A/T cg03273382 chr1:205782342 SLC41A1 -0.5 -6.43 -0.33 4.36e-10 Parkinson's disease; CRC cis rs35883536 1.000 rs2065784 chr1:101096056 A/G cg14515779 chr1:101123966 NA 0.41 7.76 0.39 1.1e-13 Monocyte count; CRC cis rs2637266 0.521 rs7906422 chr10:78298260 A/G cg18941641 chr10:78392320 NA -0.35 -5.82 -0.31 1.39e-8 Pulmonary function; CRC trans rs9291683 0.588 rs35866697 chr4:10018604 C/A cg26043149 chr18:55253948 FECH 0.51 7.82 0.4 7.29e-14 Bone mineral density; CRC cis rs9640161 0.789 rs2098053 chr7:150043205 G/A cg13722127 chr7:150037890 RARRES2 0.47 7.1 0.36 7.74e-12 Blood protein levels;Circulating chemerin levels; CRC cis rs11711311 1.000 rs7645473 chr3:113516187 T/C cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.52 -7.08 -0.36 8.83e-12 IgG glycosylation; CRC trans rs1728785 0.901 rs821169 chr16:68630184 C/T cg04657470 chr2:198365150 HSPE1;HSPD1 0.6 7.26 0.37 2.76e-12 Ulcerative colitis; CRC cis rs2456568 0.741 rs9633811 chr11:93628327 A/G cg26875233 chr11:93583750 C11orf90 0.31 5.88 0.31 1.02e-8 Response to serotonin reuptake inhibitors in major depressive disorder; CRC cis rs11628318 0.853 rs28444760 chr14:103041148 A/G cg12046867 chr14:103022105 NA -0.84 -11.91 -0.55 1.93e-27 Platelet count; CRC cis rs10982256 0.774 rs10759712 chr9:117253434 G/A cg13636371 chr9:117264095 DFNB31 -0.34 -6.51 -0.34 2.78e-10 Bipolar disorder; CRC trans rs11098499 0.863 rs6833334 chr4:120504227 C/T cg25214090 chr10:38739885 LOC399744 0.67 10.4 0.5 4.43e-22 Corneal astigmatism; CRC cis rs9381040 0.537 rs9462669 chr6:41013659 C/A cg25110423 chr6:41068646 NFYA;LOC221442 -0.38 -5.79 -0.3 1.63e-8 Alzheimer's disease (late onset); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg26706625 chr10:43800313 NA 0.38 6.26 0.33 1.17e-9 Liver disease severity in Alagille syndrome; CRC cis rs826838 1.000 rs1684416 chr12:39130301 G/A cg26384229 chr12:38710491 ALG10B -0.64 -9.67 -0.47 1.21e-19 Heart rate; CRC cis rs2380220 0.872 rs67846436 chr6:95951521 G/T cg04719120 chr6:96025338 MANEA -0.55 -6.1 -0.32 2.91e-9 Behavioural disinhibition (generation interaction); CRC cis rs55788414 0.932 rs2317119 chr16:81182854 T/C cg06400318 chr16:81190750 PKD1L2 -0.59 -6.78 -0.35 5.73e-11 Left ventricular obstructive tract defect (maternal effect); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg01546243 chr14:61748019 TMEM30B 0.42 6.31 0.33 8.92e-10 Response to antipsychotic treatment; CRC cis rs2066819 1.000 rs78121408 chr12:56684798 C/T cg26714650 chr12:56694279 CS -1.41 -11.64 -0.54 1.88e-26 Psoriasis vulgaris; CRC cis rs826838 1.000 rs7975243 chr12:38849220 C/T cg13010199 chr12:38710504 ALG10B 0.47 6.02 0.31 4.79e-9 Heart rate; CRC trans rs948562 0.744 rs78111333 chr11:58249947 G/A cg26660744 chr1:1573181 CDK11B 0.48 6.02 0.31 4.74e-9 Lymphoma; CRC cis rs6963495 0.818 rs55691539 chr7:105165774 T/C cg13798780 chr7:105162888 PUS7 0.69 8.2 0.41 5.36e-15 Bipolar disorder (body mass index interaction); CRC cis rs7666738 0.753 rs28390295 chr4:99028497 C/A cg17366294 chr4:99064904 C4orf37 0.44 7.48 0.38 6.96e-13 Colonoscopy-negative controls vs population controls; CRC trans rs2303319 0.504 rs2194732 chr2:162289156 G/A cg21546874 chr1:9294571 H6PD -0.76 -6.01 -0.31 4.89e-9 Cognitive function; CRC cis rs2070488 0.804 rs13100195 chr3:38482539 A/G cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.79 13.72 0.6 3.52e-34 Electrocardiographic conduction measures; CRC cis rs13108904 0.901 rs7695691 chr4:1304632 A/G cg20887711 chr4:1340912 KIAA1530 0.42 6.05 0.32 3.99e-9 Obesity-related traits; CRC cis rs751728 0.664 rs943474 chr6:33749834 G/C cg25922239 chr6:33757077 LEMD2 0.46 6.82 0.35 4.29e-11 Crohn's disease; CRC cis rs6463523 0.815 rs66886645 chr7:763853 C/A cg14391382 chr7:866102 UNC84A 0.54 8.07 0.41 1.37e-14 Subjective well-being; CRC cis rs875971 0.825 rs4587224 chr7:65736182 G/A cg00343986 chr7:65444356 GUSB -0.4 -5.62 -0.3 4.07e-8 Aortic root size; CRC cis rs2573652 1.000 rs2581362 chr15:100513524 T/C cg00587665 chr15:100533223 ADAMTS17 -0.35 -6.01 -0.31 4.93e-9 Height; CRC cis rs6545883 0.929 rs12617911 chr2:61740825 A/G cg15711740 chr2:61764176 XPO1 -0.52 -7.16 -0.37 5.33e-12 Tuberculosis; CRC cis rs7264396 0.887 rs224364 chr20:34063865 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.41 -6.67 -0.35 1.07e-10 Total cholesterol levels; CRC cis rs7208859 0.673 rs17826219 chr17:29161845 G/A cg13385521 chr17:29058706 SUZ12P 0.69 8.07 0.41 1.34e-14 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs73206853 0.688 rs57837519 chr12:110961082 C/T cg12870014 chr12:110450643 ANKRD13A 0.69 8.72 0.43 1.37e-16 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC cis rs853679 0.517 rs56310871 chr6:28044482 A/G cg15786705 chr6:28176104 NA 0.73 9.31 0.46 1.85e-18 Depression; CRC cis rs832540 0.656 rs6893754 chr5:56100006 G/A cg18230493 chr5:56204884 C5orf35 -0.41 -5.91 -0.31 8.45e-9 Coronary artery disease; CRC cis rs10992471 0.603 rs10761163 chr9:95313287 A/T cg14631576 chr9:95140430 CENPP -0.38 -6.6 -0.34 1.62e-10 Visceral adipose tissue/subcutaneous adipose tissue ratio; CRC cis rs4665809 0.590 rs66477033 chr2:26472497 T/C cg25036284 chr2:26402008 FAM59B 0.62 7.86 0.4 5.64e-14 Gut microbiome composition (summer); CRC cis rs720844 0.684 rs930651 chr2:149317682 C/T cg09247360 chr2:149335327 NA -0.56 -6.03 -0.32 4.49e-9 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs7605827 0.930 rs6725454 chr2:15692879 C/A cg19274914 chr2:15703543 NA 0.39 5.82 0.31 1.4e-8 Educational attainment (years of education); CRC cis rs6540559 1.000 rs12070337 chr1:209992127 G/A cg21951975 chr1:209979733 IRF6 0.46 6.54 0.34 2.4e-10 Cleft lip with or without cleft palate; CRC cis rs875971 0.830 rs778711 chr7:65851657 G/A cg18252515 chr7:66147081 NA -0.42 -5.99 -0.31 5.64e-9 Aortic root size; CRC cis rs7493 0.950 rs7785705 chr7:95033803 A/T cg07404485 chr7:94953653 PON1 -0.47 -6.24 -0.33 1.37e-9 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs877282 0.945 rs12782447 chr10:771870 C/T cg17470449 chr10:769945 NA 0.63 8.45 0.42 9.61e-16 Uric acid levels; CRC cis rs12286929 0.644 rs3793957 chr11:115095654 C/T cg04055981 chr11:115044050 NA 0.37 5.72 0.3 2.35e-8 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs514406 0.525 rs269291 chr1:53189297 C/T cg24675658 chr1:53192096 ZYG11B -0.69 -10.63 -0.51 6.87e-23 Monocyte count; CRC cis rs834811 0.563 rs17243442 chr7:135875487 A/G cg01726295 chr7:135938950 NA 0.34 5.71 0.3 2.48e-8 Post-traumatic stress disorder; CRC cis rs17362650 1.000 rs12474969 chr2:9697067 C/T cg12832956 chr2:9616023 IAH1 -0.44 -5.96 -0.31 6.58e-9 Alcohol dependence (age at onset); CRC trans rs10133840 0.963 rs2789383 chr14:95408809 G/A cg09075307 chr12:132547245 EP400 -0.46 -5.97 -0.31 6.3e-9 Body mass index (dietary energy interaction); CRC cis rs59918340 0.764 rs4961258 chr8:142232878 A/G cg03316587 chr8:142245164 NA 0.42 6.45 0.33 4.05e-10 Immature fraction of reticulocytes; CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg02113521 chr15:22892956 CYFIP1 0.4 6.55 0.34 2.19e-10 Obesity-related traits; CRC cis rs9296092 0.517 rs11751684 chr6:33528739 G/T cg13560919 chr6:33536144 NA -0.43 -5.84 -0.31 1.25e-8 Age at smoking initiation in chronic obstructive pulmonary disease; CRC trans rs9858542 0.953 rs35261698 chr3:49537839 C/G cg21659725 chr3:3221576 CRBN -0.68 -9.33 -0.46 1.64e-18 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC trans rs783540 1.000 rs1259180 chr15:83244680 T/C cg18393722 chr15:85113863 UBE2QP1 -0.4 -6.78 -0.35 5.69e-11 Schizophrenia; CRC cis rs9814567 0.929 rs1863911 chr3:134205231 C/A cg06109529 chr3:134205091 CEP63;ANAPC13 -0.8 -12.39 -0.56 3.47e-29 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs2067615 0.599 rs1579808 chr12:107239947 A/G cg13491945 chr12:107078410 RFX4 -0.35 -6.02 -0.32 4.56e-9 Heart rate; CRC cis rs801193 0.935 rs2286683 chr7:66129843 G/A cg11764359 chr7:65958608 NA -0.54 -8.3 -0.42 2.71e-15 Aortic root size; CRC cis rs6840360 0.615 rs72728171 chr4:152469372 C/A cg09659197 chr4:152720779 NA 0.31 5.66 0.3 3.25e-8 Intelligence (multi-trait analysis); CRC cis rs9443645 0.901 rs7742034 chr6:79737106 A/G cg11833968 chr6:79620685 NA -0.36 -6.15 -0.32 2.19e-9 Intelligence (multi-trait analysis); CRC cis rs1707322 1.000 rs4524994 chr1:46370263 A/G cg03146154 chr1:46216737 IPP 0.51 7.08 0.36 8.81e-12 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC trans rs9956878 0.555 rs8085188 chr18:73544676 A/G cg13898548 chr5:176924827 PDLIM7 -0.4 -6.62 -0.34 1.44e-10 Obesity-related traits; CRC cis rs11098499 0.955 rs7684942 chr4:120162201 C/T cg09307838 chr4:120376055 NA 0.61 9.41 0.46 8.75e-19 Corneal astigmatism; CRC cis rs10504229 0.596 rs7004566 chr8:58115602 G/C cg05313129 chr8:58192883 C8orf71 -0.43 -6.11 -0.32 2.74e-9 Developmental language disorder (linguistic errors); CRC cis rs7113874 0.589 rs10840058 chr11:8498399 G/T cg02811074 chr11:8615871 STK33 0.36 6.15 0.32 2.24e-9 Body mass index in physically active individuals;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs7945705 0.783 rs11042125 chr11:8938049 A/T cg00186954 chr11:8933980 ST5;C11orf17 -0.43 -6.71 -0.35 8.39e-11 Hemoglobin concentration; CRC cis rs3858526 0.514 rs1530973 chr11:5861449 C/T cg13902645 chr11:5959945 NA -0.65 -9.24 -0.45 3.14e-18 DNA methylation (variation); CRC cis rs9926296 0.605 rs12599180 chr16:89839306 C/T cg27121462 chr16:89883253 FANCA -0.55 -8.63 -0.43 2.66e-16 Vitiligo; CRC cis rs72781680 0.848 rs55725028 chr2:23966447 A/G cg08917208 chr2:24149416 ATAD2B 1.0 9.51 0.46 4.07e-19 Lymphocyte counts; CRC cis rs847577 0.630 rs6969384 chr7:97732842 C/T cg00277769 chr7:97922759 BAIAP2L1 -0.41 -6.85 -0.35 3.69e-11 Breast cancer; CRC cis rs6952808 0.608 rs6461049 chr7:2017445 C/T cg00106254 chr7:1943704 MAD1L1 0.38 5.89 0.31 9.8e-9 Bipolar disorder and schizophrenia; CRC cis rs3820068 0.581 rs72645890 chr1:15930602 A/G cg13390004 chr1:15929781 NA 0.51 7.2 0.37 4.22e-12 Systolic blood pressure; CRC cis rs7762018 0.769 rs7766146 chr6:170070135 A/T cg24289452 chr6:170231220 NA -0.67 -6.78 -0.35 5.59e-11 Thiazide-induced adverse metabolic effects in hypertensive patients; CRC cis rs2839186 0.619 rs55689527 chr21:47622727 A/G cg26721908 chr21:47610096 LSS -0.46 -7.52 -0.38 5.35e-13 Testicular germ cell tumor; CRC trans rs925098 0.577 rs2724470 chr4:17996046 A/G cg18963330 chr11:120081890 OAF -0.44 -6.31 -0.33 8.92e-10 Birth weight;Height; CRC cis rs1451375 0.617 rs11772714 chr7:50542843 G/A cg18232548 chr7:50535776 DDC -0.43 -5.66 -0.3 3.22e-8 Malaria; CRC cis rs6952808 0.723 rs55689856 chr7:2037215 G/A cg21782813 chr7:2030301 MAD1L1 0.53 9.16 0.45 5.56e-18 Bipolar disorder and schizophrenia; CRC cis rs847577 0.609 rs6465657 chr7:97816327 C/T cg00277769 chr7:97922759 BAIAP2L1 -0.41 -6.79 -0.35 5.37e-11 Breast cancer; CRC trans rs1005277 0.579 rs2474599 chr10:38438939 A/G cg17830980 chr10:43048298 ZNF37B -0.58 -9.8 -0.48 4.78e-20 Extrinsic epigenetic age acceleration; CRC cis rs910316 1.000 rs4903289 chr14:75623988 C/T cg08847533 chr14:75593920 NEK9 -0.94 -17.75 -0.7 6.25e-50 Height; CRC cis rs9868809 0.772 rs28452701 chr3:48708575 C/T cg00383909 chr3:49044727 WDR6 0.73 7.28 0.37 2.54e-12 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg06216926 chr14:92572917 ATXN3 0.45 6.61 0.34 1.53e-10 Intelligence (multi-trait analysis); CRC cis rs9911578 0.785 rs10853008 chr17:56993407 T/C cg05425664 chr17:57184151 TRIM37 0.44 6.1 0.32 3.01e-9 Intelligence (multi-trait analysis); CRC cis rs9291683 0.546 rs10939672 chr4:10052136 A/G cg02734326 chr4:10020555 SLC2A9 0.35 5.62 0.3 4.15e-8 Bone mineral density; CRC cis rs4332037 0.539 rs34809719 chr7:2028968 G/T cg24505167 chr7:1915268 MAD1L1 -0.45 -6.28 -0.33 1.09e-9 Bipolar disorder; CRC cis rs939658 0.935 rs2204069 chr15:79449335 A/G cg17916960 chr15:79447300 NA 0.48 7.91 0.4 3.86e-14 Refractive error; CRC cis rs1218582 0.740 rs1977879 chr1:154879743 G/A cg06221963 chr1:154839813 KCNN3 -0.76 -15.38 -0.65 1.34e-40 Prostate cancer; CRC cis rs17376456 0.825 rs10078941 chr5:93279029 C/T cg21475434 chr5:93447410 FAM172A 0.83 8.23 0.41 4.37e-15 Diabetic retinopathy; CRC cis rs9916302 0.904 rs7210488 chr17:37539819 T/G cg00129232 chr17:37814104 STARD3 0.53 7.96 0.4 2.76e-14 Glomerular filtration rate (creatinine); CRC cis rs9914988 0.778 rs4794837 chr17:27110024 T/C cg07195577 chr17:27052828 TLCD1 0.42 6.02 0.32 4.64e-9 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC trans rs2243480 1.000 rs313824 chr7:65581207 C/T cg10756647 chr7:56101905 PSPH 0.73 7.68 0.39 1.79e-13 Diabetic kidney disease; CRC cis rs28386778 0.863 rs894414 chr17:61916384 T/C cg06601766 chr17:61851465 DDX42;CCDC47 0.44 5.94 0.31 7.26e-9 Prudent dietary pattern; CRC cis rs2710642 0.678 rs11125946 chr2:63298150 C/T cg17519650 chr2:63277830 OTX1 -0.55 -7.82 -0.4 7.04e-14 LDL cholesterol levels;LDL cholesterol; CRC cis rs9894429 1.000 rs9674872 chr17:79581931 T/A cg18240062 chr17:79603768 NPLOC4 0.56 9.34 0.46 1.54e-18 Eye color traits; CRC cis rs7586879 0.616 rs916485 chr2:25082273 T/C cg04586622 chr2:25135609 ADCY3 -0.54 -10.07 -0.49 5.8e-21 Body mass index; CRC cis rs344364 0.511 rs2982446 chr16:1947153 C/T cg14074117 chr16:1909714 C16orf73 0.42 5.88 0.31 1.03e-8 Glomerular filtration rate in chronic kidney disease; CRC cis rs4654899 0.758 rs1354792 chr1:21391875 C/T cg02927042 chr1:21476669 EIF4G3 0.38 5.85 0.31 1.19e-8 Superior frontal gyrus grey matter volume; CRC cis rs270601 0.633 rs4535443 chr5:131572561 A/G cg20512303 chr5:131592959 PDLIM4 0.41 7.25 0.37 3.04e-12 Acylcarnitine levels; CRC cis rs881375 0.967 rs1860824 chr9:123659339 G/T cg09586646 chr9:123605570 PSMD5;LOC253039 0.53 7.18 0.37 4.57e-12 Rheumatoid arthritis; CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg04703844 chr8:74207197 RPL7;RDH10 -0.55 -6.7 -0.35 8.96e-11 Diisocyanate-induced asthma; CRC cis rs6456156 0.586 rs12525855 chr6:167480013 T/G cg23791538 chr6:167370224 RNASET2 -0.39 -5.79 -0.3 1.67e-8 Primary biliary cholangitis; CRC cis rs11628318 0.802 rs2277471 chr14:103024387 A/C cg02094049 chr14:103021097 NA 0.44 5.79 0.3 1.6e-8 Platelet count; CRC cis rs6121246 0.567 rs6060247 chr20:30190720 C/G cg13852791 chr20:30311386 BCL2L1 0.58 7.72 0.39 1.4e-13 Mean corpuscular hemoglobin; CRC cis rs1448094 0.511 rs17345299 chr12:86166005 C/G cg25456477 chr12:86230367 RASSF9 0.38 6.32 0.33 8.37e-10 Major depressive disorder; CRC cis rs910316 1.000 rs3742780 chr14:75505008 G/C cg11812906 chr14:75593930 NEK9 0.63 10.03 0.48 8.12e-21 Height; CRC cis rs1552244 1.000 rs66838678 chr3:10150350 G/A cg10729496 chr3:10149963 C3orf24 0.55 7.1 0.36 7.93e-12 Alzheimer's disease; CRC cis rs72772090 0.539 rs72773989 chr5:96163613 C/T cg17330273 chr5:96107758 CAST;ERAP1 -0.63 -6.09 -0.32 3.23e-9 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs9503598 0.714 rs11242859 chr6:3454032 G/A cg00476032 chr6:3446245 SLC22A23 0.38 6.25 0.33 1.24e-9 Cognitive ability (multi-trait analysis);Cognitive ability;Intelligence (multi-trait analysis); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg04389262 chr14:89882592 FOXN3 0.44 6.26 0.33 1.23e-9 Intelligence (multi-trait analysis); CRC cis rs6754311 0.773 rs309137 chr2:136765951 A/G cg15123519 chr2:136567270 LCT -0.33 -6.21 -0.32 1.62e-9 Mosquito bite size; CRC cis rs7208859 0.623 rs7219361 chr17:29080393 G/A cg13385521 chr17:29058706 SUZ12P 0.7 7.93 0.4 3.5e-14 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs9527 0.590 rs2182348 chr10:104872684 A/G cg04362960 chr10:104952993 NT5C2 0.61 8.46 0.42 8.85e-16 Arsenic metabolism; CRC cis rs10256972 0.732 rs1574108 chr7:1105805 T/C cg03188948 chr7:1209495 NA 0.42 6.05 0.32 3.98e-9 Longevity;Endometriosis; CRC cis rs780096 0.526 rs11126999 chr2:27670307 G/A cg12000995 chr2:27665139 KRTCAP3 -0.32 -6.44 -0.33 4.29e-10 Total body bone mineral density; CRC cis rs7224685 1.000 rs1377807 chr17:4045440 C/G cg09695851 chr17:3907499 NA 0.44 6.05 0.32 3.89e-9 Type 2 diabetes; CRC cis rs6912958 1.000 rs6933587 chr6:88175577 T/G cg08069147 chr6:88032118 GJB7;C6orf162 -0.57 -8.6 -0.43 3.37e-16 Monocyte percentage of white cells; CRC cis rs7264396 0.623 rs6119609 chr20:34039394 G/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.43 -7.02 -0.36 1.29e-11 Total cholesterol levels; CRC cis rs6951245 0.678 rs28600085 chr7:1169636 C/T cg22907277 chr7:1156413 C7orf50 0.78 9.01 0.45 1.66e-17 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs34172651 0.517 rs7204288 chr16:24784531 A/G cg00339695 chr16:24857497 SLC5A11 0.43 8.74 0.43 1.18e-16 Intelligence (multi-trait analysis); CRC cis rs1499614 0.901 rs2178742 chr7:66197799 G/A cg18252515 chr7:66147081 NA -1.24 -14.49 -0.62 3.96e-37 Gout; CRC trans rs8073060 0.544 rs225252 chr17:33952401 G/A cg19694781 chr19:47549865 TMEM160 -1.05 -14.75 -0.63 3.75e-38 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; CRC cis rs9811920 0.809 rs793475 chr3:99543764 A/G cg07805332 chr3:99536008 MIR548G;C3orf26 0.39 6.09 0.32 3.13e-9 Axial length; CRC cis rs7618501 0.521 rs11709573 chr3:49956628 C/T cg24308560 chr3:49941425 MST1R -0.44 -6.64 -0.34 1.32e-10 Intelligence (multi-trait analysis); CRC cis rs11809207 0.953 rs17163666 chr1:26525383 A/G cg24519413 chr1:26490540 NA 0.41 5.64 0.3 3.62e-8 Height; CRC cis rs7584330 0.554 rs3751110 chr2:238427142 T/C cg14458575 chr2:238380390 NA 0.46 6.53 0.34 2.47e-10 Prostate cancer; CRC cis rs7849270 1.000 rs3118632 chr9:131901284 G/A cg13538475 chr9:131942899 NA 0.33 6.35 0.33 7.11e-10 Blood metabolite ratios; CRC cis rs763121 0.853 rs1056610 chr22:39080078 C/T cg06022373 chr22:39101656 GTPBP1 -0.82 -13.49 -0.6 2.57e-33 Menopause (age at onset); CRC trans rs2727020 0.658 rs10839278 chr11:49450847 G/C cg03929089 chr4:120376271 NA -0.87 -16.2 -0.67 8.2e-44 Coronary artery disease; CRC cis rs10870270 0.830 rs10781571 chr10:133774316 G/C cg08754478 chr10:133766260 PPP2R2D -0.66 -9.23 -0.45 3.28e-18 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; CRC cis rs7177699 0.557 rs9806363 chr15:79110302 A/G cg15571903 chr15:79123663 NA -0.31 -6.06 -0.32 3.65e-9 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; CRC cis rs11123610 0.520 rs35752035 chr2:3721353 G/C cg10645314 chr2:3704589 ALLC -0.54 -6.29 -0.33 1.02e-9 Response to inhaled corticosteroid treatment in asthma (change in FEV1); CRC cis rs1218582 0.772 rs1976559 chr1:154879788 A/T cg24250549 chr1:154909240 PMVK 0.65 11.29 0.53 3.2e-25 Prostate cancer; CRC cis rs10751667 0.666 rs10902235 chr11:938892 T/C ch.11.42038R chr11:967971 AP2A2 0.58 9.85 0.48 3.1e-20 Alzheimer's disease (late onset); CRC trans rs116095464 0.558 rs6869925 chr5:264036 A/G cg00938859 chr5:1591904 SDHAP3 0.73 7.89 0.4 4.53e-14 Breast cancer; CRC cis rs172166 0.611 rs203883 chr6:28078356 A/G cg12273811 chr6:28175739 NA 0.61 8.84 0.44 5.98e-17 Cardiac Troponin-T levels; CRC cis rs881375 0.967 rs7034653 chr9:123687372 G/A cg09586646 chr9:123605570 PSMD5;LOC253039 0.48 6.58 0.34 1.82e-10 Rheumatoid arthritis; CRC cis rs1448094 0.511 rs17345975 chr12:86202318 T/A cg18827107 chr12:86230957 RASSF9 -0.38 -6.05 -0.32 4.03e-9 Major depressive disorder; CRC cis rs7843479 0.544 rs7839925 chr8:21792983 G/C cg17168535 chr8:21777572 XPO7 0.66 11.26 0.53 4.32e-25 Mean corpuscular volume; CRC cis rs9916302 0.904 rs7501488 chr17:37576417 T/G cg07936489 chr17:37558343 FBXL20 -0.85 -13.38 -0.59 6.93e-33 Glomerular filtration rate (creatinine); CRC cis rs9488822 0.676 rs6918059 chr6:116349041 C/T cg26893134 chr6:116381904 FRK 0.27 7.96 0.4 2.77e-14 Cholesterol, total;LDL cholesterol; CRC cis rs79349575 0.651 rs4378658 chr17:46993370 G/A cg22482690 chr17:47019901 SNF8 0.48 8.01 0.4 2.05e-14 Type 2 diabetes; CRC cis rs752010 0.905 rs10890150 chr1:42095603 A/C cg06885757 chr1:42089581 HIVEP3 0.51 8.87 0.44 4.71e-17 Lupus nephritis in systemic lupus erythematosus; CRC cis rs644799 0.601 rs662168 chr11:95586982 C/T cg03916912 chr11:95522834 CEP57;FAM76B 0.75 12.83 0.58 7.56e-31 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs2415984 0.579 rs1389606 chr14:46964226 T/C cg14871534 chr14:47121158 RPL10L 0.4 5.96 0.31 6.64e-9 Number of children ever born; CRC cis rs7786808 0.564 rs10267128 chr7:158198490 G/A cg17401720 chr7:158221031 PTPRN2 -0.41 -6.74 -0.35 7.22e-11 Obesity-related traits; CRC cis rs7223966 1.000 rs55868506 chr17:61851686 T/G cg23090583 chr17:61904693 PSMC5;FTSJ3 0.5 6.21 0.32 1.62e-9 Hip circumference adjusted for BMI;Body mass index; CRC cis rs16830122 0.514 rs67849779 chr1:154611208 G/A cg17218026 chr1:154582156 ADAR -0.47 -6.12 -0.32 2.59e-9 Alzheimer's disease in APOE e4- carriers; CRC cis rs7666738 0.822 rs17484018 chr4:98988960 G/A cg05340658 chr4:99064831 C4orf37 0.61 9.54 0.47 3.21e-19 Colonoscopy-negative controls vs population controls; CRC cis rs13108904 0.901 rs1680073 chr4:1280337 G/A cg21620606 chr4:1342894 KIAA1530 -0.43 -7.81 -0.4 7.76e-14 Obesity-related traits; CRC cis rs2243480 0.908 rs313822 chr7:65573939 G/A cg12463550 chr7:65579703 CRCP 0.66 6.15 0.32 2.28e-9 Diabetic kidney disease; CRC cis rs6088580 0.634 rs4277599 chr20:33008905 A/G cg24642439 chr20:33292090 TP53INP2 -0.36 -6.31 -0.33 9.24e-10 Glomerular filtration rate (creatinine); CRC cis rs523522 0.962 rs2168319 chr12:120933217 C/T cg27279351 chr12:120934652 DYNLL1 0.75 11.3 0.53 3.15e-25 High light scatter reticulocyte count; CRC trans rs11098499 0.599 rs3864142 chr4:120266191 A/T cg25214090 chr10:38739885 LOC399744 0.53 8.51 0.42 6.36e-16 Corneal astigmatism; CRC cis rs2243480 1.000 rs34702770 chr7:65344823 T/C cg12463550 chr7:65579703 CRCP 0.66 6.14 0.32 2.36e-9 Diabetic kidney disease; CRC cis rs9903692 0.954 rs9747001 chr17:46154669 G/A cg21215337 chr17:46176117 CBX1 0.42 7.79 0.39 8.93e-14 Pulse pressure; CRC cis rs2952156 0.920 rs1565920 chr17:37831613 G/A cg20243544 chr17:37824526 PNMT 0.56 8.95 0.44 2.59e-17 Asthma; CRC cis rs9399137 0.507 rs13197750 chr6:135312380 G/A cg24558204 chr6:135376177 HBS1L 0.62 9.46 0.46 5.88e-19 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; CRC trans rs2303319 0.504 rs1023835 chr2:162593973 A/G cg14875682 chr5:52083620 ITGA1;PELO -0.73 -6.16 -0.32 2.11e-9 Cognitive function; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg02203542 chr20:305175 SOX12 0.46 6.41 0.33 5.07e-10 Response to antipsychotic treatment; CRC cis rs7085104 0.660 rs7902804 chr10:104585405 A/T cg04362960 chr10:104952993 NT5C2 0.63 9.16 0.45 5.75e-18 Immature fraction of reticulocytes;Schizophrenia; CRC cis rs912057 0.526 rs746453 chr6:6734221 C/A cg06612196 chr6:6737390 NA 0.58 9.5 0.46 4.38e-19 Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction); CRC cis rs7586879 0.681 rs28836469 chr2:25117215 A/G cg22495460 chr2:25135724 ADCY3 -0.87 -17.11 -0.69 2.25e-47 Body mass index; CRC cis rs6502050 0.830 rs8074436 chr17:80158422 A/G cg19223190 chr17:80058835 NA 0.41 6.7 0.35 8.79e-11 Life satisfaction; CRC trans rs916888 0.773 rs169201 chr17:44790203 A/G cg23590916 chr17:43697445 MGC57346 0.73 7.27 0.37 2.72e-12 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC trans rs3942852 0.622 rs6485806 chr11:48102806 A/G cg15704280 chr7:45808275 SEPT13 0.57 7.33 0.37 1.75e-12 Acute lymphoblastic leukemia (childhood); CRC cis rs9297145 0.585 rs10953283 chr7:98782750 A/G cg05967295 chr7:98741636 SMURF1 0.56 8.7 0.43 1.57e-16 Crohn's disease;Inflammatory bowel disease;Ulcerative colitis; CRC cis rs2816062 0.786 rs2745317 chr1:18896552 G/A cg18795169 chr1:18902165 NA -0.92 -19.57 -0.73 4.36e-57 Urate levels in lean individuals; CRC cis rs7727544 0.582 rs2278398 chr5:131530441 C/T cg18758796 chr5:131593413 PDLIM4 -0.33 -5.71 -0.3 2.58e-8 Blood metabolite levels; CRC cis rs7481584 0.624 rs516443 chr11:3047294 A/G cg25174290 chr11:3078921 CARS -0.4 -5.65 -0.3 3.5e-8 Calcium levels; CRC cis rs9372498 0.505 rs62422250 chr6:118990182 T/C cg15382696 chr6:118971807 C6orf204 0.6 7.01 0.36 1.34e-11 Diastolic blood pressure; CRC cis rs62064224 0.546 rs1018866 chr17:30829664 A/C cg21839984 chr17:30846986 MYO1D -0.45 -7.65 -0.39 2.28e-13 Schizophrenia; CRC cis rs2576037 0.583 rs487386 chr18:44377004 A/G cg19077165 chr18:44547161 KATNAL2 -0.54 -8.59 -0.43 3.49e-16 Personality dimensions; CRC cis rs2108622 0.727 rs12610967 chr19:15977929 C/A cg13772218 chr19:15982569 NA 0.48 6.69 0.35 9.62e-11 Circulating phylloquinone levels;Vitamin E levels;Acenocoumarol maintenance dosage;Response to Vitamin E supplementation;Metabolite levels;Warfarin maintenance dose; CRC cis rs11650494 0.710 rs16948071 chr17:47468706 T/G cg08112188 chr17:47440006 ZNF652 0.81 6.52 0.34 2.72e-10 Prostate cancer; CRC cis rs317689 0.613 rs315112 chr12:69785926 T/A cg19645103 chr12:69753606 YEATS4 -0.44 -5.76 -0.3 1.9e-8 Response to diuretic therapy; CRC cis rs6088580 0.634 rs4911418 chr20:32994257 G/A cg24642439 chr20:33292090 TP53INP2 -0.37 -6.31 -0.33 8.76e-10 Glomerular filtration rate (creatinine); CRC cis rs651907 0.514 rs11706494 chr3:101509475 A/T cg12386194 chr3:101231763 SENP7 0.52 7.45 0.38 8.17e-13 Colorectal cancer; CRC cis rs4819052 0.851 rs9753963 chr21:46661437 G/A cg11663144 chr21:46675770 NA -0.83 -14.12 -0.61 9.88e-36 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC trans rs4927850 1.000 rs7630875 chr3:195753766 A/G cg16724585 chr3:197361211 NA -0.47 -7.08 -0.36 9.03e-12 Pancreatic cancer; CRC cis rs12711979 0.512 rs1466227 chr2:3832358 T/C cg17052675 chr2:3827356 NA -0.35 -5.92 -0.31 7.96e-9 Itch intensity from mosquito bite adjusted by bite size; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg12530254 chr20:17949265 C20orf72;SNX5 0.48 6.18 0.32 1.93e-9 Anxiety disorder; CRC cis rs67311347 1.000 rs9841335 chr3:40475858 G/A cg09455208 chr3:40491958 NA 0.43 8.72 0.43 1.36e-16 Renal cell carcinoma; CRC cis rs8038465 0.622 rs7182124 chr15:73915254 C/T cg15420318 chr15:73925796 NPTN 0.44 7.0 0.36 1.45e-11 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs6662572 0.737 rs9429187 chr1:46558927 C/A cg03123370 chr1:45965343 CCDC163P;MMACHC 0.47 6.25 0.33 1.29e-9 Blood protein levels; CRC cis rs4588572 0.537 rs7719228 chr5:77730576 G/A cg11446398 chr5:77624930 NA 0.41 5.89 0.31 9.63e-9 Triglycerides; CRC cis rs1552244 0.808 rs7615088 chr3:10035896 A/T cg16606324 chr3:10149918 C3orf24 0.62 8.08 0.41 1.25e-14 Alzheimer's disease; CRC cis rs728616 0.614 rs61859191 chr10:82091027 T/C cg05935833 chr10:81318306 SFTPA2 -0.57 -7.0 -0.36 1.48e-11 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs2033711 0.870 rs4801583 chr19:58918405 A/G cg13877915 chr19:58951672 ZNF132 0.51 8.42 0.42 1.14e-15 Uric acid clearance; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg12822074 chr11:57243865 RTN4RL2 0.37 6.23 0.32 1.43e-9 Liver disease severity in Alagille syndrome; CRC cis rs7945705 0.902 rs2012696 chr11:8995818 A/C cg12365402 chr11:9010492 NRIP3 0.52 8.64 0.43 2.57e-16 Hemoglobin concentration; CRC cis rs2463822 1.000 rs118049526 chr11:62107508 C/T cg06239285 chr11:62104954 ASRGL1 -1.02 -10.21 -0.49 1.89e-21 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs875971 0.862 rs3893216 chr7:65790707 G/C cg18876405 chr7:65276391 NA -0.54 -8.68 -0.43 1.88e-16 Aortic root size; CRC cis rs35264875 1.000 rs35264875 chr11:68846399 A/T cg03469862 chr11:68924853 NA 0.45 5.78 0.3 1.76e-8 Blond vs. brown hair color; CRC cis rs6545883 0.525 rs1177274 chr2:61368532 T/G cg10580144 chr2:61372316 C2orf74 0.28 5.78 0.3 1.7e-8 Tuberculosis; CRC cis rs4919694 1.000 rs35159404 chr10:104805610 C/A cg04362960 chr10:104952993 NT5C2 1.1 10.28 0.49 1.15e-21 Arsenic metabolism; CRC cis rs7914558 1.000 rs7094843 chr10:104806654 A/C cg15744005 chr10:104629667 AS3MT -0.33 -7.05 -0.36 1.04e-11 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC trans rs62103177 0.525 rs612913 chr18:77845882 A/G cg05926928 chr17:57297772 GDPD1 -0.58 -6.01 -0.31 4.91e-9 Opioid sensitivity; CRC cis rs1023500 0.573 rs133370 chr22:42465260 T/C cg04733989 chr22:42467013 NAGA 0.57 8.7 0.43 1.6e-16 Schizophrenia; CRC cis rs3018066 0.666 rs28868894 chr4:107035282 C/T cg01869342 chr4:106983673 TBCK 0.42 5.66 0.3 3.38e-8 Cancer; CRC cis rs9322193 0.847 rs9505972 chr6:150096391 A/C cg00933542 chr6:150070202 PCMT1 0.31 6.01 0.31 4.88e-9 Lung cancer; CRC cis rs875971 0.660 rs62465434 chr7:66005152 A/C cg05627663 chr7:65219948 SNORA22;CCT6P1 0.43 6.46 0.34 3.8e-10 Aortic root size; CRC cis rs7091068 0.566 rs7098349 chr10:95514907 A/C cg20715218 chr10:95462985 C10orf4 0.54 5.67 0.3 3.08e-8 Urinary tract infection frequency; CRC cis rs7208859 0.623 rs609063 chr17:28951513 A/G cg13385521 chr17:29058706 SUZ12P 0.58 6.42 0.33 4.89e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs7727544 0.735 rs273914 chr5:131660431 A/T cg07395648 chr5:131743802 NA -0.39 -6.23 -0.32 1.4e-9 Blood metabolite levels; CRC cis rs2243480 1.000 rs313807 chr7:65499481 C/T cg12463550 chr7:65579703 CRCP 0.68 6.32 0.33 8.38e-10 Diabetic kidney disease; CRC cis rs4423214 0.959 rs12794668 chr11:71168715 C/T cg05163923 chr11:71159392 DHCR7 0.64 9.07 0.45 1.08e-17 Vitamin D levels; CRC cis rs9818758 0.607 rs5030795 chr3:49141116 C/T cg07636037 chr3:49044803 WDR6 -0.65 -5.71 -0.3 2.54e-8 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; CRC cis rs4819052 0.851 rs2838839 chr21:46667858 C/G cg19498844 chr21:46707878 POFUT2;LOC642852 -0.75 -10.72 -0.51 3.45e-23 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC trans rs9784649 0.760 rs72755820 chr5:25066181 G/A cg08600765 chr20:34638493 LOC647979 -0.64 -8.36 -0.42 1.73e-15 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs11148252 0.532 rs9536262 chr13:53303074 A/C cg02158880 chr13:53174818 NA -0.56 -9.25 -0.45 3.01e-18 Lewy body disease; CRC cis rs9911578 1.000 rs4636974 chr17:56965373 C/G cg12560992 chr17:57184187 TRIM37 0.92 16.96 0.68 8.06e-47 Intelligence (multi-trait analysis); CRC cis rs7259376 0.514 rs11673221 chr19:22492035 T/C cg02657401 chr19:22469223 NA -0.3 -6.56 -0.34 2.07e-10 Menopause (age at onset); CRC cis rs2046867 0.818 rs67355490 chr3:72830935 T/C cg25664220 chr3:72788482 NA -0.45 -6.37 -0.33 6.38e-10 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; CRC cis rs2739330 0.828 rs2330635 chr22:24251344 T/C cg04234412 chr22:24373322 LOC391322 -0.72 -11.31 -0.53 2.92e-25 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs4803455 0.565 rs11670143 chr19:41864971 A/G cg08477640 chr19:41863820 B9D2 0.48 7.45 0.38 8.22e-13 Migraine;Coronary artery disease; CRC cis rs10751667 0.621 rs7394862 chr11:927500 T/C cg01483505 chr11:975446 AP2A2 0.43 6.87 0.35 3.27e-11 Alzheimer's disease (late onset); CRC cis rs9987353 0.519 rs2929465 chr8:9064002 C/G cg06636001 chr8:8085503 FLJ10661 -0.44 -7.09 -0.36 8.35e-12 Recombination measurement; CRC cis rs6598955 0.671 rs17162105 chr1:26591255 A/G cg04990556 chr1:26633338 UBXN11 0.56 6.02 0.32 4.53e-9 Obesity-related traits; CRC cis rs1215050 0.765 rs783947 chr4:99012943 T/C cg05340658 chr4:99064831 C4orf37 -0.49 -7.58 -0.39 3.57e-13 Waist-to-hip ratio adjusted for body mass index; CRC cis rs801193 0.967 rs2420827 chr7:66147101 G/A cg00343986 chr7:65444356 GUSB -0.45 -6.54 -0.34 2.3e-10 Aortic root size; CRC cis rs4665809 1.000 rs4233708 chr2:26291345 C/T cg27170947 chr2:26402098 FAM59B -0.44 -5.85 -0.31 1.16e-8 Gut microbiome composition (summer); CRC cis rs7584330 0.554 rs79213383 chr2:238426890 A/G cg14458575 chr2:238380390 NA 0.46 6.53 0.34 2.47e-10 Prostate cancer; CRC cis rs9522267 0.535 rs9522286 chr13:112230909 A/G cg14352298 chr13:112236639 NA 0.3 6.71 0.35 8.5e-11 Hepatitis; CRC cis rs9549328 0.731 rs7983602 chr13:113620482 A/G cg08614441 chr13:113633676 MCF2L -0.5 -8.87 -0.44 4.61e-17 Systolic blood pressure; CRC cis rs3760982 0.585 rs61013802 chr19:44292142 A/T cg11993925 chr19:44307056 LYPD5 0.57 10.13 0.49 3.57e-21 Breast cancer (estrogen-receptor negative);Breast cancer; CRC cis rs34864796 0.547 rs200476 chr6:27768348 A/T cg12172441 chr6:28176163 NA 0.48 5.66 0.3 3.34e-8 Lung function (FEV1);Lung function (FEV1/FVC);Lung function (FVC); CRC cis rs7927771 0.832 rs7105851 chr11:47383275 T/C cg20307385 chr11:47447363 PSMC3 0.63 9.26 0.45 2.68e-18 Subjective well-being; CRC cis rs1223397 1.000 rs1223399 chr6:13271220 G/A cg20827128 chr6:13274284 PHACTR1 0.53 6.52 0.34 2.69e-10 Blood pressure; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg25883402 chr1:173837173 SNORD76;SNORD74;SNORD75;GAS5;ZBTB37 0.43 6.14 0.32 2.36e-9 Intelligence (multi-trait analysis); CRC cis rs7178572 0.568 rs12900433 chr15:77495028 T/C cg22256960 chr15:77711686 NA -0.67 -9.56 -0.47 2.93e-19 Type 2 diabetes; CRC cis rs523522 1.000 rs1563333 chr12:120934407 C/T cg12219531 chr12:120966889 COQ5 0.62 8.42 0.42 1.16e-15 High light scatter reticulocyte count; CRC cis rs6912958 0.559 rs183599 chr6:88061024 C/T cg12350822 chr6:88032061 C6orf162;GJB7 0.44 9.1 0.45 8.97e-18 Monocyte percentage of white cells; CRC cis rs11252926 0.574 rs4881254 chr10:453567 C/T cg16386425 chr10:429943 DIP2C -0.43 -6.57 -0.34 1.91e-10 Psychosis in Alzheimer's disease; CRC cis rs2228479 0.850 rs11645916 chr16:89835234 G/A cg06558623 chr16:89946397 TCF25 1.13 10.49 0.5 2.06e-22 Skin colour saturation; CRC cis rs1865760 0.532 rs9295687 chr6:26082710 T/C cg18357526 chr6:26021779 HIST1H4A 0.43 6.09 0.32 3.08e-9 Height; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg23508540 chr1:9884032 CLSTN1 0.43 6.77 0.35 5.98e-11 Liver disease severity in Alagille syndrome; CRC cis rs9372498 0.536 rs9481825 chr6:118876092 C/T cg24463073 chr6:118973353 C6orf204 0.49 6.65 0.34 1.22e-10 Diastolic blood pressure; CRC cis rs7772486 0.625 rs2050027 chr6:146116113 C/G cg13319975 chr6:146136371 FBXO30 0.46 6.98 0.36 1.6e-11 Lobe attachment (rater-scored or self-reported); CRC cis rs3749237 0.595 rs1464568 chr3:49458266 G/A cg07636037 chr3:49044803 WDR6 0.54 7.88 0.4 4.91e-14 Resting heart rate; CRC cis rs1619661 0.505 rs10899997 chr10:44683841 T/G cg09554077 chr10:44749378 NA 0.47 7.14 0.37 6.09e-12 QT interval (ambient particulate matter interaction); CRC cis rs6424115 1.000 rs7514394 chr1:24100223 A/G cg15997130 chr1:24165203 NA -0.67 -10.61 -0.51 7.86e-23 Immature fraction of reticulocytes; CRC cis rs7523050 0.643 rs34367763 chr1:109400805 C/T cg08274380 chr1:109419600 GPSM2 0.84 6.6 0.34 1.69e-10 Fat distribution (HIV); CRC cis rs4862750 1.000 rs4862750 chr4:187904043 C/T cg07414643 chr4:187882934 NA 0.35 5.87 0.31 1.06e-8 Lobe attachment (rater-scored or self-reported); CRC cis rs3760982 1.000 rs11669175 chr19:44289824 A/G cg12072164 chr19:44306565 LYPD5 0.41 6.42 0.33 4.75e-10 Breast cancer (estrogen-receptor negative);Breast cancer; CRC cis rs921968 0.643 rs2303561 chr2:219527005 C/T cg02176678 chr2:219576539 TTLL4 -0.48 -7.65 -0.39 2.19e-13 Mean corpuscular hemoglobin concentration; CRC cis rs12936587 0.576 rs8073975 chr17:17555631 G/T cg09796270 chr17:17721594 SREBF1 -0.46 -7.78 -0.39 9.38e-14 Hip circumference;Coronary artery disease or large artery stroke;Coronary heart disease;Coronary artery disease; CRC trans rs10155879 0.505 rs12704265 chr7:86142678 A/G cg09567212 chr6:37787045 ZFAND3 0.59 6.32 0.33 8.62e-10 Interleukin-4 levels; CRC cis rs7615952 0.599 rs2333408 chr3:125732098 G/A cg18479299 chr3:125709523 NA -0.5 -6.47 -0.34 3.65e-10 Blood pressure (smoking interaction); CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg04924415 chr12:100661456 SCYL2;DEPDC4 -0.4 -6.11 -0.32 2.77e-9 Myopia (pathological); CRC cis rs9611565 0.512 rs5751153 chr22:42156561 T/C cg06481639 chr22:41940642 POLR3H 0.55 6.05 0.32 3.91e-9 Vitiligo; CRC cis rs769267 1.000 rs769267 chr19:19446936 A/G cg01262667 chr19:19385393 TM6SF2 0.39 6.6 0.34 1.65e-10 Tonsillectomy; CRC cis rs1552244 1.000 rs6764068 chr3:10153842 A/G cg16606324 chr3:10149918 C3orf24 0.72 9.48 0.46 5.05e-19 Alzheimer's disease; CRC cis rs7666738 0.830 rs34671152 chr4:98978177 C/T cg05340658 chr4:99064831 C4orf37 0.6 9.35 0.46 1.41e-18 Colonoscopy-negative controls vs population controls; CRC cis rs7772486 0.686 rs6570705 chr6:145961201 C/T cg05347473 chr6:146136440 FBXO30 0.37 5.71 0.3 2.55e-8 Lobe attachment (rater-scored or self-reported); CRC cis rs950776 0.593 rs601079 chr15:78869579 T/A cg06917634 chr15:78832804 PSMA4 -0.57 -8.81 -0.44 7.32e-17 Sudden cardiac arrest; CRC cis rs6834538 0.558 rs701760 chr4:113439212 C/G cg10021238 chr4:113569128 MIR367;LARP7 -0.39 -6.46 -0.34 3.84e-10 Free thyroxine concentration; CRC cis rs8103278 0.507 rs7260651 chr19:46260245 G/A cg11657440 chr19:46296263 DMWD 0.7 12.22 0.56 1.42e-28 Coronary artery disease; CRC cis rs6951245 1.000 rs1997243 chr7:1083777 A/G cg03188948 chr7:1209495 NA 0.63 6.54 0.34 2.29e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs9372498 0.572 rs62422190 chr6:118909235 A/G cg22561889 chr6:118971681 C6orf204 0.47 5.9 0.31 8.96e-9 Diastolic blood pressure; CRC trans rs7395662 1.000 rs12806328 chr11:48647971 G/A cg21153622 chr11:89784906 NA -0.48 -7.76 -0.39 1.06e-13 HDL cholesterol; CRC cis rs3733346 0.553 rs6813110 chr4:942660 C/T cg15105011 chr4:940614 TMEM175 0.48 8.13 0.41 9.1e-15 Sjögren's syndrome; CRC cis rs2408955 0.521 rs10875753 chr12:48557141 C/T cg21466736 chr12:48725269 NA -0.47 -7.33 -0.37 1.81e-12 Glycated hemoglobin levels; CRC trans rs11039798 0.565 rs7118675 chr11:48532063 C/A cg03929089 chr4:120376271 NA 0.64 6.64 0.34 1.26e-10 Axial length; CRC cis rs11212617 0.934 rs10890834 chr11:108286443 C/T cg14761454 chr11:108092087 ATM;NPAT 0.43 6.61 0.34 1.52e-10 Response to metformin in type 2 diabetes (glycemic); CRC cis rs9303542 0.625 rs17703660 chr17:46567134 T/C cg04904318 chr17:46607828 HOXB1 -0.51 -5.81 -0.31 1.44e-8 Ovarian cancer;Epithelial ovarian cancer; CRC cis rs9814567 1.000 rs6801596 chr3:134252114 C/T cg06109529 chr3:134205091 CEP63;ANAPC13 -0.8 -11.99 -0.55 9.75e-28 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs208515 0.556 rs12201658 chr6:66678457 T/C cg07460842 chr6:66804631 NA 0.93 11.66 0.54 1.56e-26 Exhaled nitric oxide levels; CRC trans rs2303319 0.504 rs56965753 chr2:162597251 A/G cg10498984 chr16:28874827 SH2B1 -0.73 -6.3 -0.33 9.75e-10 Cognitive function; CRC cis rs898097 0.625 rs6502017 chr17:80891135 C/T cg15369054 chr17:80825471 TBCD -0.35 -5.9 -0.31 8.9e-9 Breast cancer; CRC cis rs2836633 1.000 rs2836633 chr21:40067445 C/T cg05519781 chr21:40033154 ERG -0.6 -11.23 -0.53 5.42e-25 Coronary artery disease; CRC cis rs17253792 0.822 rs77741349 chr14:56097462 C/T cg24579896 chr14:56047964 C14orf33;KTN1 0.71 5.69 0.3 2.81e-8 Putamen volume; CRC trans rs1814175 0.645 rs1851850 chr11:50012168 G/A cg03929089 chr4:120376271 NA -0.89 -16.02 -0.66 4.26e-43 Height; CRC cis rs2404602 0.536 rs1587381 chr15:76769620 G/A cg26408565 chr15:76604113 ETFA -0.37 -5.8 -0.3 1.55e-8 Blood metabolite levels; CRC cis rs2242116 0.592 rs2290545 chr3:46967040 C/T cg27129171 chr3:47204927 SETD2 0.52 6.39 0.33 5.66e-10 Birth weight; CRC cis rs9393692 0.875 rs6939589 chr6:26289203 C/T cg13736514 chr6:26305472 NA 0.61 11.36 0.53 1.83e-25 Educational attainment; CRC cis rs12594515 1.000 rs6493175 chr15:45989898 T/C cg06207120 chr15:45996521 NA 0.32 7.75 0.39 1.14e-13 Waist circumference;Weight; CRC cis rs3749237 0.595 rs885592 chr3:49497883 T/G cg07636037 chr3:49044803 WDR6 0.56 8.04 0.41 1.63e-14 Resting heart rate; CRC cis rs7618915 0.547 rs11130315 chr3:52697163 A/G cg08222913 chr3:52553049 STAB1 -0.34 -6.23 -0.32 1.45e-9 Bipolar disorder; CRC cis rs155076 0.702 rs482731 chr13:21846075 G/A cg25811766 chr13:21894605 NA -0.57 -5.99 -0.31 5.45e-9 White matter hyperintensity burden; CRC cis rs735396 1.000 rs1169309 chr12:121439192 G/T cg02403541 chr12:121454288 C12orf43 0.45 6.71 0.35 8.4e-11 N-glycan levels; CRC cis rs514406 0.607 rs6665324 chr1:53201610 G/A cg24675658 chr1:53192096 ZYG11B 0.72 11.92 0.55 1.85e-27 Monocyte count; CRC cis rs1552244 0.882 rs67762674 chr3:10014485 C/T cg18598329 chr3:10140678 FANCD2;C3orf24 -0.81 -10.56 -0.5 1.26e-22 Alzheimer's disease; CRC cis rs10489202 0.632 rs202268 chr1:167927339 T/C cg24449463 chr1:168025552 DCAF6 -0.59 -8.54 -0.43 4.96e-16 Schizophrenia; CRC trans rs146671954 1 rs146671954 chr9:136934203 G/A cg09836344 chr4:1243392 C4orf42;CTBP1 -0.57 -6.06 -0.32 3.65e-9 Red cell distribution width; CRC cis rs9308731 1.000 rs6750599 chr2:111893869 A/T cg04202892 chr2:111875749 ACOXL -0.36 -5.83 -0.31 1.31e-8 Chronic lymphocytic leukemia; CRC cis rs116095464 0.558 rs9687621 chr5:229194 C/T cg22857025 chr5:266934 NA -1.16 -12.13 -0.56 3.01e-28 Breast cancer; CRC cis rs56399783 0.901 rs73047387 chr7:2774125 G/A cg19731401 chr7:2775893 GNA12 0.66 6.93 0.36 2.16e-11 Childhood ear infection; CRC trans rs10504229 1.000 rs67705655 chr8:58177688 G/A cg04077850 chr5:125800366 GRAMD3 0.37 6.27 0.33 1.15e-9 Developmental language disorder (linguistic errors); CRC cis rs28386778 0.897 rs9912557 chr17:61784963 C/A cg07362569 chr17:61921086 SMARCD2 0.37 5.65 0.3 3.47e-8 Prudent dietary pattern; CRC cis rs2832191 0.740 rs2012645 chr21:30445961 G/A cg08807101 chr21:30365312 RNF160 0.71 11.57 0.54 3.39e-26 Dental caries; CRC trans rs2727020 0.729 rs588458 chr11:49214048 C/A cg21153622 chr11:89784906 NA 0.43 6.9 0.36 2.64e-11 Coronary artery disease; CRC cis rs2153535 0.542 rs9393012 chr6:8439809 G/A cg21535247 chr6:8435926 SLC35B3 0.48 7.26 0.37 2.78e-12 Motion sickness; CRC cis rs3796352 1.000 rs2564926 chr3:53094730 G/A cg06204229 chr3:52865917 ITIH4 -0.49 -6.09 -0.32 3.18e-9 Immune reponse to smallpox (secreted IL-2); CRC trans rs208520 0.909 rs9345809 chr6:67017543 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.83 9.86 0.48 2.82e-20 Exhaled nitric oxide output; CRC cis rs7224685 0.501 rs11652060 chr17:4010412 A/T cg11204139 chr17:3907470 NA -0.78 -14.23 -0.62 3.89e-36 Type 2 diabetes; CRC cis rs17021463 0.676 rs13124715 chr4:95313382 C/T cg11021082 chr4:95130006 SMARCAD1 0.42 5.94 0.31 7.06e-9 Testicular germ cell tumor; CRC cis rs34172651 0.517 rs2547040 chr16:24736408 G/C cg00339695 chr16:24857497 SLC5A11 -0.44 -9.18 -0.45 4.93e-18 Intelligence (multi-trait analysis); CRC trans rs10802346 0.545 rs6662672 chr1:246387611 A/C cg22732515 chr19:44031385 ETHE1 0.69 10.39 0.5 4.57e-22 Fractional exhaled nitric oxide (childhood); CRC cis rs782590 0.643 rs13009906 chr2:55739434 A/G cg18811423 chr2:55921094 PNPT1 -0.67 -10.22 -0.49 1.84e-21 Metabolic syndrome; CRC cis rs1572438 0.895 rs12202771 chr6:857147 C/T cg13447295 chr6:887704 NA -0.42 -6.19 -0.32 1.84e-9 Aging; CRC cis rs7666738 0.830 rs34412187 chr4:99010454 A/G cg05340658 chr4:99064831 C4orf37 0.61 9.54 0.47 3.44e-19 Colonoscopy-negative controls vs population controls; CRC cis rs78545713 0.649 rs11753717 chr6:26220202 G/C cg01420254 chr6:26195488 NA 0.66 5.87 0.31 1.04e-8 Iron status biomarkers (total iron binding capacity); CRC cis rs4523957 0.651 rs9908373 chr17:2086534 G/A cg16513277 chr17:2031491 SMG6 -0.61 -9.97 -0.48 1.2e-20 Autism spectrum disorder or schizophrenia;Schizophrenia; CRC cis rs9326248 0.798 rs10892079 chr11:117016824 T/G cg11861562 chr11:117069780 TAGLN 0.4 8.28 0.42 3.11e-15 Blood protein levels; CRC cis rs66731853 0.769 rs530104 chr1:20895721 A/G cg04087271 chr1:20915334 CDA -0.38 -6.4 -0.33 5.2e-10 Mean corpuscular volume; CRC cis rs7542091 1.000 rs7542091 chr1:210031948 G/C cg22029157 chr1:209979665 IRF6 0.52 8.47 0.42 8.14e-16 Monobrow; CRC cis rs9381040 0.610 rs6941090 chr6:41043465 G/A cg04346459 chr6:41068666 NFYA;LOC221442 -0.4 -5.82 -0.31 1.43e-8 Alzheimer's disease (late onset); CRC cis rs12477438 0.561 rs2084988 chr2:99655755 T/C cg14399236 chr2:99771627 LIPT1;TSGA10 -0.6 -8.19 -0.41 6.03e-15 Chronic sinus infection; CRC cis rs796364 0.906 rs6740981 chr2:201060216 T/C cg12253985 chr2:200820533 C2orf60;C2orf47 0.52 5.93 0.31 7.86e-9 Schizophrenia; CRC cis rs28386778 0.830 rs2597637 chr17:61875066 T/G cg07362569 chr17:61921086 SMARCD2 0.37 5.7 0.3 2.64e-8 Prudent dietary pattern; CRC cis rs9393692 0.620 rs9358927 chr6:26330492 T/G cg13736514 chr6:26305472 NA -0.46 -7.58 -0.39 3.67e-13 Educational attainment; CRC cis rs853679 0.550 rs1233704 chr6:28166923 A/G cg12273811 chr6:28175739 NA -0.76 -10.97 -0.52 4.41e-24 Depression; CRC cis rs1799949 0.965 rs8176323 chr17:41195711 G/C cg23758822 chr17:41437982 NA 0.8 13.7 0.6 4.08e-34 Menopause (age at onset); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg12075144 chr3:155588060 GMPS 0.38 6.15 0.32 2.3e-9 Liver disease severity in Alagille syndrome; CRC cis rs614226 0.935 rs17431717 chr12:120912210 G/A cg27489772 chr12:121021490 NA -0.48 -6.25 -0.33 1.26e-9 Type 1 diabetes nephropathy; CRC cis rs1150668 0.699 rs1531681 chr6:28226878 A/G cg03623178 chr6:28175578 NA 0.51 7.65 0.39 2.25e-13 Pubertal anthropometrics; CRC cis rs9910055 0.529 rs400460 chr17:42182770 A/G cg19774624 chr17:42201019 HDAC5 0.43 5.84 0.31 1.27e-8 Total body bone mineral density; CRC cis rs72781680 0.715 rs72796332 chr2:24142060 G/A cg08917208 chr2:24149416 ATAD2B 0.55 6.71 0.35 8.52e-11 Lymphocyte counts; CRC cis rs6662572 0.806 rs11211133 chr1:45991079 G/A cg08644498 chr1:46502608 NA 0.42 6.0 0.31 5.12e-9 Blood protein levels; CRC cis rs514406 0.825 rs487453 chr1:53271225 T/C cg24675658 chr1:53192096 ZYG11B 0.59 9.23 0.45 3.31e-18 Monocyte count; CRC cis rs2108622 0.727 rs55954696 chr19:15981805 A/G cg13772218 chr19:15982569 NA 0.48 6.81 0.35 4.52e-11 Circulating phylloquinone levels;Vitamin E levels;Acenocoumarol maintenance dosage;Response to Vitamin E supplementation;Metabolite levels;Warfarin maintenance dose; CRC cis rs4319547 0.619 rs7973869 chr12:122874284 G/C cg05707623 chr12:122985044 ZCCHC8 -0.69 -8.35 -0.42 1.96e-15 Body mass index; CRC cis rs7647973 0.516 rs4499638 chr3:49202782 C/G cg06212747 chr3:49208901 KLHDC8B 0.38 5.7 0.3 2.67e-8 Menarche (age at onset); CRC cis rs9487051 0.872 rs9386789 chr6:109603218 A/G cg12927641 chr6:109611667 NA -0.36 -6.57 -0.34 1.99e-10 Reticulocyte fraction of red cells; CRC cis rs28386778 0.830 rs7209321 chr17:61855668 A/C cg23090583 chr17:61904693 PSMC5;FTSJ3 1.02 18.69 0.72 1.29e-53 Prudent dietary pattern; CRC cis rs7119 0.651 rs8041398 chr15:77839173 A/G cg10437265 chr15:77819839 NA 0.58 10.16 0.49 2.83e-21 Type 2 diabetes; CRC cis rs10504229 0.511 rs75967910 chr8:58024231 C/G cg11062466 chr8:58055876 NA 0.54 6.65 0.34 1.22e-10 Developmental language disorder (linguistic errors); CRC cis rs2075371 0.932 rs2598290 chr7:133987736 C/G cg02659138 chr7:134003124 SLC35B4 0.37 6.41 0.33 5.15e-10 Mean platelet volume; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg00567536 chr3:47422272 PTPN23 0.48 6.61 0.34 1.58e-10 Response to antipsychotic treatment; CRC trans rs925098 0.577 rs2724470 chr4:17996046 A/G cg00628130 chr8:95908808 CCNE2 -0.44 -6.33 -0.33 8.21e-10 Birth weight;Height; CRC cis rs7312933 0.612 rs10785334 chr12:42620377 A/G cg19980929 chr12:42632907 YAF2 -0.43 -6.35 -0.33 7.35e-10 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CRC cis rs9925964 0.967 rs2032915 chr16:31117413 C/T cg03418659 chr16:31128414 MYST1 0.5 7.3 0.37 2.15e-12 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs4604732 0.642 rs4489599 chr1:247635213 C/T cg02104434 chr1:247694406 LOC148824;OR2C3 -0.43 -7.19 -0.37 4.35e-12 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CRC cis rs4973397 0.519 rs1729082 chr2:232196472 T/A cg13347044 chr2:232276743 NA 0.41 6.19 0.32 1.79e-9 Anti-saccade response; CRC cis rs4713675 0.584 rs3227 chr6:33662295 G/C cg14003231 chr6:33640908 ITPR3 0.49 7.95 0.4 3.04e-14 Plateletcrit; CRC cis rs1005277 0.541 rs1740741 chr10:38515334 C/T cg17219203 chr10:38645113 HSD17B7P2 -0.41 -5.92 -0.31 8.11e-9 Extrinsic epigenetic age acceleration; CRC cis rs4481887 0.741 rs1361413 chr1:248529521 C/G cg26353448 chr1:248524236 OR2T4 0.34 6.5 0.34 3.03e-10 Common traits (Other); CRC cis rs2439831 0.850 rs2228368 chr15:44102010 A/C cg02155558 chr15:43621948 ADAL;LCMT2 0.67 7.39 0.38 1.19e-12 Lung cancer in ever smokers; CRC cis rs4588572 0.644 rs6873144 chr5:77741784 C/T cg11446398 chr5:77624930 NA 0.42 6.02 0.31 4.66e-9 Triglycerides; CRC trans rs1455244 0.700 rs7229302 chr18:11508904 G/T cg16505237 chr8:145550609 DGAT1 0.42 6.22 0.32 1.48e-9 Schizophrenia; CRC cis rs7493 1.000 rs6961773 chr7:95037718 T/G cg20119798 chr7:94954144 PON1 -0.5 -6.34 -0.33 7.49e-10 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs7394190 0.748 rs12572278 chr10:75504513 C/A cg07699608 chr10:75541558 CHCHD1 0.7 6.76 0.35 6.2e-11 Incident atrial fibrillation; CRC cis rs853679 0.546 rs200952 chr6:27836976 C/T cg19041857 chr6:27730383 NA -0.71 -6.71 -0.35 8.65e-11 Depression; CRC cis rs10504229 0.724 rs58715581 chr8:58134568 A/G cg02290350 chr8:58132656 NA -0.58 -8.16 -0.41 7.29e-15 Developmental language disorder (linguistic errors); CRC cis rs16937 0.640 rs6664706 chr1:205182563 T/C cg24159697 chr1:205181237 DSTYK -0.33 -6.01 -0.31 4.83e-9 Schizophrenia; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg05892773 chr1:112282121 C1orf183 0.5 6.97 0.36 1.73e-11 Response to antipsychotic treatment; CRC cis rs883565 0.696 rs7620304 chr3:39079623 T/A cg01426195 chr3:39028469 NA -0.53 -8.54 -0.43 4.97e-16 Handedness; CRC cis rs2290159 0.800 rs56363132 chr3:12680403 T/C cg23032965 chr3:12705835 RAF1 0.5 6.38 0.33 5.92e-10 Cholesterol, total; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg05775451 chr1:228353712 C1orf69 -0.42 -6.25 -0.33 1.3e-9 Myopia (pathological); CRC cis rs853679 0.517 rs35193936 chr6:28076270 A/G cg15845792 chr6:28175446 NA 0.99 13.1 0.59 7.48e-32 Depression; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg17079325 chr7:130131480 MEST;MESTIT1 0.24 6.16 0.32 2.14e-9 Liver disease severity in Alagille syndrome; CRC cis rs9372498 0.536 rs9489399 chr6:118767147 C/A cg01339444 chr6:118972232 C6orf204 0.52 5.87 0.31 1.08e-8 Diastolic blood pressure; CRC cis rs7647973 0.925 rs9834003 chr3:49216472 T/C cg07636037 chr3:49044803 WDR6 0.64 7.87 0.4 5.33e-14 Menarche (age at onset); CRC cis rs72717009 0.825 rs867624 chr1:161467837 A/T cg15358701 chr1:161410459 NA -0.66 -6.88 -0.35 3.1e-11 Rheumatoid arthritis; CRC cis rs2985684 1.000 rs3007031 chr14:50102269 G/C cg04989706 chr14:50066350 PPIL5 -0.5 -7.02 -0.36 1.25e-11 Carotid intima media thickness; CRC cis rs7923609 0.934 rs10761771 chr10:65230164 T/C cg08743896 chr10:65200160 JMJD1C -0.42 -6.05 -0.32 3.87e-9 Educational attainment;Liver enzyme levels (alkaline phosphatase); CRC cis rs9487051 1.000 rs9487048 chr6:109615603 G/T cg12927641 chr6:109611667 NA -0.32 -5.61 -0.3 4.19e-8 Reticulocyte fraction of red cells; CRC cis rs6502050 0.835 rs8078087 chr17:80113322 T/G cg19223190 chr17:80058835 NA 0.4 6.36 0.33 6.88e-10 Life satisfaction; CRC cis rs12024301 0.557 rs77855373 chr1:183598435 A/G cg11505048 chr1:183622726 RGL1;APOBEC4 0.76 6.93 0.36 2.16e-11 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs6545883 0.965 rs1992765 chr2:61751333 A/G cg15711740 chr2:61764176 XPO1 -0.51 -7.05 -0.36 1.03e-11 Tuberculosis; CRC cis rs4713118 0.662 rs149970 chr6:27980220 C/T cg23161317 chr6:28129485 ZNF389 0.46 6.12 0.32 2.6e-9 Parkinson's disease; CRC cis rs10886503 0.777 rs4752317 chr10:121264341 C/A cg17804342 chr10:121271663 RGS10 0.78 7.55 0.38 4.29e-13 Obstetric antiphospholipid syndrome; CRC cis rs904251 0.523 rs1757191 chr6:37482871 C/T cg25019722 chr6:37503610 NA -0.46 -8.64 -0.43 2.4e-16 Cognitive performance; CRC cis rs9814567 0.793 rs55940445 chr3:134306064 G/T cg06109529 chr3:134205091 CEP63;ANAPC13 0.82 11.75 0.54 7.24e-27 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs1799949 0.501 rs9675035 chr17:41415016 A/T cg25072359 chr17:41440525 NA 0.45 6.86 0.35 3.32e-11 Menopause (age at onset); CRC cis rs875971 0.862 rs4718377 chr7:66049678 C/T cg18876405 chr7:65276391 NA -0.53 -8.61 -0.43 3.18e-16 Aortic root size; CRC cis rs6502050 0.835 rs6502070 chr17:80112634 G/A cg13198984 chr17:80129470 CCDC57 0.46 8.19 0.41 5.84e-15 Life satisfaction; CRC cis rs780096 0.546 rs1647284 chr2:27608115 C/T cg02592271 chr2:27665507 KRTCAP3 -0.26 -5.97 -0.31 6e-9 Total body bone mineral density; CRC cis rs798554 0.679 rs798499 chr7:2792013 G/A cg04166393 chr7:2884313 GNA12 0.41 6.3 0.33 9.8e-10 Height; CRC cis rs4964805 1.000 rs4964806 chr12:104192760 C/T cg02344784 chr12:104178138 NT5DC3 0.55 8.37 0.42 1.67e-15 Attention deficit hyperactivity disorder; CRC cis rs12950390 0.853 rs4793647 chr17:45854090 G/C cg24803719 chr17:45855879 NA -0.32 -7.02 -0.36 1.24e-11 IgG glycosylation; CRC cis rs1448094 0.512 rs7308229 chr12:86239849 A/T cg25456477 chr12:86230367 RASSF9 -0.36 -6.19 -0.32 1.76e-9 Major depressive disorder; CRC cis rs62408225 1.000 rs62408222 chr6:90948476 A/G cg06866423 chr6:90926672 BACH2 0.47 7.67 0.39 1.91e-13 Eosinophil counts;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC cis rs6502050 0.835 rs8073351 chr17:80127625 A/G cg13198984 chr17:80129470 CCDC57 0.46 8.13 0.41 9e-15 Life satisfaction; CRC cis rs733592 0.931 rs765260 chr12:48431936 C/T cg24011408 chr12:48396354 COL2A1 -0.38 -5.7 -0.3 2.63e-8 Plateletcrit; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg16322302 chr3:49157769 USP19 0.46 6.55 0.34 2.26e-10 Response to antipsychotic treatment; CRC cis rs7119 0.604 rs2271396 chr15:77907535 C/G cg10437265 chr15:77819839 NA -0.44 -7.98 -0.4 2.52e-14 Type 2 diabetes; CRC cis rs4654899 1.000 rs885363 chr1:21325360 C/A cg02927042 chr1:21476669 EIF4G3 -0.48 -7.79 -0.39 8.94e-14 Superior frontal gyrus grey matter volume; CRC cis rs1387259 0.839 rs7486941 chr12:48578631 C/G cg21466736 chr12:48725269 NA 0.49 7.6 0.39 3.21e-13 Obstructive sleep apnea trait (apnea hypopnea index); CRC cis rs10197940 0.578 rs2432957 chr2:152287897 A/C cg19508488 chr2:152266495 RIF1 0.47 6.79 0.35 5.4e-11 Lung cancer; CRC cis rs1348850 0.793 rs6734528 chr2:178493731 G/A cg22681709 chr2:178499509 PDE11A -0.41 -7.52 -0.38 5.43e-13 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs210143 1 rs210143 chr6:33546930 T/C cg07679836 chr6:33548423 BAK1 0.35 5.79 0.3 1.65e-8 Neutrophil percentage of granulocytes;B-cell malignancies (chronic lymphocytic leukemia, Hodgkin lymphoma or multiple myeloma) (pleiotropy);Chronic lymphocytic leukemia; CRC cis rs1448094 0.506 rs61930640 chr12:86173333 T/C cg02569458 chr12:86230093 RASSF9 0.49 8.02 0.4 1.85e-14 Major depressive disorder; CRC cis rs6088580 0.634 rs6058070 chr20:33103521 G/C cg08999081 chr20:33150536 PIGU 0.64 11.5 0.54 6.02e-26 Glomerular filtration rate (creatinine); CRC cis rs2625529 0.617 rs7175373 chr15:72203517 G/T cg16672083 chr15:72433130 SENP8 0.44 6.7 0.35 9.25e-11 Red blood cell count; CRC cis rs3204270 1.000 rs3204270 chr17:79682051 C/T cg09655341 chr17:79618100 PDE6G 0.57 5.89 0.31 9.33e-9 Dental caries; CRC cis rs10256972 0.732 rs12701856 chr7:1107707 C/T cg22907277 chr7:1156413 C7orf50 0.5 7.16 0.37 5.22e-12 Longevity;Endometriosis; CRC cis rs2327429 0.767 rs12190287 chr6:134214525 C/G cg06296503 chr6:134217401 NA -0.45 -7.78 -0.39 9.76e-14 Coronary artery disease; CRC cis rs10992471 0.729 rs13284038 chr9:95555488 A/G cg13798575 chr9:95087839 CENPP;NOL8 -0.43 -6.09 -0.32 3.14e-9 Visceral adipose tissue/subcutaneous adipose tissue ratio; CRC cis rs6951245 0.706 rs28685743 chr7:1197736 C/T cg24642844 chr7:1081250 C7orf50 -0.65 -7.9 -0.4 4.11e-14 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs1552244 1.000 rs17032268 chr3:10067972 C/T cg16606324 chr3:10149918 C3orf24 0.69 9.43 0.46 7.91e-19 Alzheimer's disease; CRC cis rs2304069 0.550 rs216144 chr5:149445480 T/C cg22760475 chr5:149380129 HMGXB3;TIGD6 0.65 7.74 0.39 1.21e-13 HIV-1 control; CRC cis rs7927592 0.956 rs12271290 chr11:68326236 A/G cg16797656 chr11:68205561 LRP5 -0.35 -5.63 -0.3 3.96e-8 Total body bone mineral density; CRC cis rs950169 0.544 rs2036949 chr15:85163605 T/C cg17507749 chr15:85114479 UBE2QP1 0.63 9.02 0.45 1.58e-17 Schizophrenia; CRC cis rs8014204 0.839 rs6574197 chr14:75331487 A/G cg03030879 chr14:75389066 RPS6KL1 0.56 8.96 0.44 2.39e-17 Caffeine consumption; CRC trans rs6951245 0.554 rs75075857 chr7:1140298 C/T cg13565492 chr6:43139072 SRF -0.83 -10.59 -0.5 9.71e-23 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC trans rs7267979 1.000 rs6083804 chr20:25317060 A/G cg17903999 chr18:56338584 MALT1 0.42 6.91 0.36 2.48e-11 Liver enzyme levels (alkaline phosphatase); CRC cis rs798554 0.660 rs2527694 chr7:2858240 T/C cg19717773 chr7:2847554 GNA12 -0.48 -8.17 -0.41 6.59e-15 Height; CRC cis rs6952808 0.564 rs73038441 chr7:2139286 T/C cg22963979 chr7:1858916 MAD1L1 -0.46 -6.63 -0.34 1.36e-10 Bipolar disorder and schizophrenia; CRC cis rs17270561 0.583 rs6908407 chr6:25703656 A/T cg16482183 chr6:26056742 HIST1H1C -0.72 -9.17 -0.45 5.43e-18 Iron status biomarkers; CRC cis rs1153858 1.000 rs10444821 chr15:45647236 C/T cg10760299 chr15:45669010 GATM 0.49 7.79 0.39 8.71e-14 Homoarginine levels; CRC cis rs8072100 0.967 rs7219303 chr17:45737701 A/G cg25173405 chr17:45401733 C17orf57 0.44 6.9 0.36 2.61e-11 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs7937682 0.924 rs513425 chr11:111504861 C/T cg09085632 chr11:111637200 PPP2R1B -0.99 -19.28 -0.73 5.84e-56 Primary sclerosing cholangitis; CRC cis rs4713118 0.824 rs2092075 chr6:27749330 G/C cg25164649 chr6:28176230 NA 0.6 7.91 0.4 3.87e-14 Parkinson's disease; CRC trans rs1455244 0.700 rs7229302 chr18:11508904 G/T cg23442955 chr1:55680982 USP24 0.4 6.48 0.34 3.31e-10 Schizophrenia; CRC cis rs5417 0.775 rs222852 chr17:7140606 A/G cg14660024 chr17:7154518 C17orf81;DULLARD -0.5 -8.38 -0.42 1.6e-15 Diastolic blood pressure; CRC cis rs6912958 0.967 rs6905947 chr6:88161949 C/T cg12350822 chr6:88032061 C6orf162;GJB7 -0.44 -8.58 -0.43 3.84e-16 Monocyte percentage of white cells; CRC cis rs877282 0.755 rs1769242 chr10:787896 T/C cg17470449 chr10:769945 NA 0.45 6.28 0.33 1.07e-9 Uric acid levels; CRC cis rs2976388 0.578 rs13263987 chr8:143827387 A/C cg15511327 chr8:143859410 LYNX1 -0.4 -6.34 -0.33 7.39e-10 Urinary tract infection frequency; CRC cis rs769267 1.000 rs2074089 chr19:19449603 G/A cg03709012 chr19:19516395 GATAD2A -0.67 -10.29 -0.49 1.03e-21 Tonsillectomy; CRC cis rs10791097 0.765 rs4622274 chr11:130729486 C/T cg12179176 chr11:130786555 SNX19 0.67 10.89 0.51 8.69e-24 Autism spectrum disorder or schizophrenia;Schizophrenia; CRC cis rs12950390 0.814 rs4794099 chr17:45838358 T/C cg24803719 chr17:45855879 NA -0.3 -6.54 -0.34 2.31e-10 IgG glycosylation; CRC cis rs3806843 0.933 rs2240696 chr5:140168070 A/G cg19875535 chr5:140030758 IK 0.6 9.78 0.47 5.3e-20 Depressive symptoms (multi-trait analysis); CRC cis rs9640161 0.789 rs10282458 chr7:150045302 C/T cg13722127 chr7:150037890 RARRES2 0.41 6.4 0.33 5.5e-10 Blood protein levels;Circulating chemerin levels; CRC cis rs7843479 0.601 rs11780532 chr8:21838670 T/A cg16476235 chr8:21771668 DOK2 0.4 6.94 0.36 2.07e-11 Mean corpuscular volume; CRC cis rs41271473 0.526 rs10916339 chr1:228716894 C/T cg16512390 chr1:228756714 NA 0.66 7.03 0.36 1.18e-11 Chronic lymphocytic leukemia; CRC cis rs3858526 0.883 rs10769333 chr11:5939685 A/T cg02574844 chr11:5959923 NA -0.42 -5.9 -0.31 8.85e-9 DNA methylation (variation); CRC trans rs3749237 1.000 rs2307021 chr3:49765483 C/G cg21665057 chr3:196295764 WDR53;FBXO45 0.51 6.98 0.36 1.62e-11 Resting heart rate; CRC cis rs9900062 1.000 rs2521879 chr17:62742678 A/G cg02598441 chr17:62777298 LOC146880 -0.59 -7.0 -0.36 1.41e-11 QT interval; CRC cis rs780096 0.526 rs13391837 chr2:27649375 A/G cg17158414 chr2:27665306 KRTCAP3 -0.29 -6.26 -0.33 1.2e-9 Total body bone mineral density; CRC cis rs853679 0.517 rs3173443 chr6:28137027 T/G cg12273811 chr6:28175739 NA 0.73 9.16 0.45 5.8e-18 Depression; CRC cis rs6831352 0.734 rs2602857 chr4:100030318 G/A cg12011299 chr4:100065546 ADH4 0.45 8.75 0.43 1.11e-16 Alcohol dependence; CRC cis rs950169 0.724 rs11632668 chr15:84948687 T/C cg11189052 chr15:85197271 WDR73 0.63 8.81 0.44 7.5e-17 Schizophrenia; CRC cis rs561341 0.941 rs2428338 chr17:30299629 T/C cg23018236 chr17:30244563 NA -0.59 -7.93 -0.4 3.43e-14 Hip circumference adjusted for BMI; CRC trans rs2727020 0.688 rs2734002 chr11:49234162 A/G cg21153622 chr11:89784906 NA 0.41 6.53 0.34 2.52e-10 Coronary artery disease; CRC trans rs877282 0.945 rs11253397 chr10:789774 A/G cg22713356 chr15:30763199 NA 1.34 16.68 0.68 1.08e-45 Uric acid levels; CRC cis rs9323205 0.765 rs2999390 chr14:51654944 C/G cg23942311 chr14:51606299 NA -0.57 -9.28 -0.46 2.42e-18 Cancer; CRC cis rs28386778 0.897 rs2584610 chr17:61934783 T/C cg06873352 chr17:61820015 STRADA 0.77 14.34 0.62 1.49e-36 Prudent dietary pattern; CRC cis rs477895 0.653 rs12797120 chr11:63906819 C/T cg23719950 chr11:63933701 MACROD1 -0.65 -8.25 -0.41 3.82e-15 Mean platelet volume; CRC cis rs11098499 1.000 rs28419773 chr4:120211061 T/C cg09307838 chr4:120376055 NA 0.65 9.99 0.48 1.08e-20 Corneal astigmatism; CRC cis rs4319547 0.698 rs4039670 chr12:122822655 A/G cg23029597 chr12:123009494 RSRC2 -0.5 -6.2 -0.32 1.72e-9 Body mass index; CRC cis rs1215050 0.765 rs783925 chr4:98969881 T/C cg05340658 chr4:99064831 C4orf37 -0.49 -7.52 -0.38 5.41e-13 Waist-to-hip ratio adjusted for body mass index; CRC cis rs17739167 0.532 rs8035074 chr15:42239779 C/T cg20935245 chr15:42234343 EHD4 0.38 6.02 0.31 4.72e-9 Monocyte count; CRC cis rs1448094 0.511 rs10506920 chr12:86165212 A/T cg19622623 chr12:86230825 RASSF9 -0.38 -5.85 -0.31 1.18e-8 Major depressive disorder; CRC cis rs8014671 0.531 rs12880777 chr14:70874695 A/G cg25576086 chr14:70833871 SYNJ2BP -0.36 -6.1 -0.32 2.91e-9 Prostate cancer; CRC cis rs4713118 0.614 rs9380007 chr6:27660508 T/C cg20933634 chr6:27740509 NA 0.39 5.79 0.3 1.61e-8 Parkinson's disease; CRC cis rs2303759 0.551 rs7249040 chr19:49790602 C/T cg22307029 chr19:49891270 CCDC155 0.68 9.06 0.45 1.17e-17 Multiple sclerosis; CRC cis rs447 0.848 rs9969195 chr7:83753142 T/C cg22846510 chr7:83753280 SEMA3A -0.6 -7.73 -0.39 1.3e-13 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs9467711 0.720 rs7749823 chr6:26158079 A/C cg16898833 chr6:26189333 HIST1H4D 0.68 6.24 0.33 1.35e-9 Autism spectrum disorder or schizophrenia; CRC cis rs6712932 0.962 rs2053241 chr2:105842228 G/A cg20265528 chr2:105853269 NA -0.33 -5.6 -0.3 4.51e-8 Type 2 diabetes; CRC cis rs1448094 0.817 rs73176252 chr12:86347649 T/A cg00310523 chr12:86230176 RASSF9 0.44 7.48 0.38 7.04e-13 Major depressive disorder; CRC cis rs6121246 0.909 rs2376992 chr20:30263418 T/C cg07809909 chr20:30433512 FOXS1 0.35 5.74 0.3 2.11e-8 Mean corpuscular hemoglobin; CRC cis rs9322193 0.923 rs9404048 chr6:149937324 C/T cg05861140 chr6:150128134 PCMT1 -0.36 -5.85 -0.31 1.17e-8 Lung cancer; CRC cis rs977987 0.836 rs8055974 chr16:75470986 C/G cg03315344 chr16:75512273 CHST6 0.56 9.58 0.47 2.43e-19 Dupuytren's disease; CRC cis rs2806561 0.765 rs2806557 chr1:23503372 T/A cg12483005 chr1:23474871 LUZP1 0.51 7.41 0.38 1.06e-12 Height; CRC trans rs9630182 0.561 rs10832040 chr11:13473207 C/A cg13741668 chr9:85679694 NA 0.37 6.03 0.32 4.51e-9 Bone mineral density; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg21705844 chr17:3539499 SHPK;CTNS 0.47 7.19 0.37 4.37e-12 Intelligence (multi-trait analysis); CRC cis rs2732480 0.577 rs2732457 chr12:48758379 A/G cg21466736 chr12:48725269 NA 0.58 8.54 0.43 4.97e-16 Hemoglobin concentration;Red blood cell count;Hematocrit; CRC cis rs875971 0.502 rs2946580 chr7:65531842 G/A cg18876405 chr7:65276391 NA -0.46 -6.3 -0.33 9.54e-10 Aortic root size; CRC cis rs17270561 0.609 rs9393655 chr6:25711338 A/G cg16482183 chr6:26056742 HIST1H1C 0.73 9.24 0.45 3.05e-18 Iron status biomarkers; CRC cis rs933688 0.938 rs7720235 chr5:90659329 A/T cg26981201 chr5:90679533 LOC100129716;ARRDC3 1.01 17.23 0.69 7.57e-48 Smoking behavior; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg06966887 chr5:443603 EXOC3;C5orf55 0.48 6.2 0.32 1.69e-9 Thyroid stimulating hormone; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg15813570 chr14:64854563 MTHFD1 0.47 6.19 0.32 1.8e-9 Thyroid stimulating hormone; CRC trans rs11764590 0.715 rs9639202 chr7:2087315 G/A cg11693508 chr17:37793320 STARD3 0.6 6.91 0.36 2.59e-11 Neuroticism; CRC cis rs13256369 0.760 rs7816171 chr8:8575835 T/C cg17143192 chr8:8559678 CLDN23 0.48 6.45 0.33 4.09e-10 Obesity-related traits; CRC cis rs2404602 0.647 rs7178250 chr15:77099107 T/C cg23625390 chr15:77176239 SCAPER -0.85 -13.72 -0.6 3.53e-34 Blood metabolite levels; CRC cis rs11608355 0.545 rs2302703 chr12:109898832 G/A cg05360138 chr12:110035743 NA 0.77 8.7 0.43 1.65e-16 Neuroticism; CRC cis rs2882667 0.858 rs11750382 chr5:138456994 A/G cg09476006 chr5:138032270 NA -0.43 -6.62 -0.34 1.46e-10 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs6502050 0.835 rs7503111 chr17:80101587 A/T cg13198984 chr17:80129470 CCDC57 0.46 8.16 0.41 6.94e-15 Life satisfaction; CRC cis rs834811 0.623 rs1097151 chr7:135883871 A/G cg01726295 chr7:135938950 NA -0.41 -7.03 -0.36 1.17e-11 Post-traumatic stress disorder; CRC trans rs2303319 0.504 rs1006427 chr2:162592328 T/C cg22988483 chr14:93581567 ITPK1 -0.66 -6.07 -0.32 3.52e-9 Cognitive function; CRC cis rs514406 0.861 rs1571979 chr1:53237526 G/A cg25767906 chr1:53392781 SCP2 0.45 7.23 0.37 3.5e-12 Monocyte count; CRC cis rs6761276 0.899 rs11891557 chr2:113835319 G/A cg24553058 chr2:113831203 IL1F10 0.39 6.3 0.33 9.43e-10 Protein quantitative trait loci; CRC cis rs1862618 0.853 rs832565 chr5:56150803 T/G cg18230493 chr5:56204884 C5orf35 -0.72 -9.21 -0.45 4.06e-18 Initial pursuit acceleration; CRC trans rs3942852 1.000 rs3942852 chr11:48115089 C/T cg15704280 chr7:45808275 SEPT13 -0.56 -6.84 -0.35 3.77e-11 Acute lymphoblastic leukemia (childhood); CRC cis rs11864453 0.713 rs3764312 chr16:72125733 A/C cg01557791 chr16:72042693 DHODH -0.44 -6.14 -0.32 2.36e-9 Fibrinogen levels; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg25563067 chr17:20059234 CYTSB 0.45 7.7 0.39 1.5700000000000001e-13 Liver disease severity in Alagille syndrome; CRC cis rs6142102 0.961 rs2284386 chr20:32644396 G/A cg08999081 chr20:33150536 PIGU 0.38 5.94 0.31 7.26e-9 Skin pigmentation; CRC cis rs2243480 1.000 rs466983 chr7:65520496 T/G cg18252515 chr7:66147081 NA -1.17 -12.85 -0.58 6.56e-31 Diabetic kidney disease; CRC cis rs16852403 0.548 rs3748788 chr1:178202807 A/G cg00404053 chr1:178313656 RASAL2 0.5 6.55 0.34 2.21e-10 Childhood ear infection; CRC cis rs875971 0.862 rs10263690 chr7:65766453 G/C cg12463550 chr7:65579703 CRCP -0.49 -6.67 -0.35 1.09e-10 Aortic root size; CRC cis rs911119 0.955 rs6114201 chr20:23607231 T/A cg16589663 chr20:23618590 CST3 0.47 6.73 0.35 7.35e-11 Chronic kidney disease; CRC cis rs7107174 1.000 rs2512538 chr11:77972461 T/G cg02023728 chr11:77925099 USP35 0.52 7.37 0.38 1.43e-12 Testicular germ cell tumor; CRC cis rs2721195 0.967 rs10108150 chr8:145687475 A/G cg11211951 chr8:145729740 GPT -0.39 -6.75 -0.35 6.5e-11 Age at first birth; CRC cis rs11628318 0.763 rs11623312 chr14:103022060 G/T cg12046867 chr14:103022105 NA -0.79 -10.77 -0.51 2.28e-23 Platelet count; CRC cis rs7762018 0.655 rs2184194 chr6:170148394 C/T cg19338460 chr6:170058176 WDR27 -0.69 -7.6 -0.39 3.03e-13 Thiazide-induced adverse metabolic effects in hypertensive patients; CRC cis rs11785400 0.793 rs10956992 chr8:143736235 A/C cg10596483 chr8:143751796 JRK 0.47 6.38 0.33 5.95e-10 Schizophrenia; CRC cis rs7789940 0.904 rs56919252 chr7:75937520 T/C cg10167463 chr7:75959203 YWHAG -0.7 -9.15 -0.45 5.93e-18 Multiple sclerosis; CRC cis rs875971 0.545 rs6969224 chr7:65834998 T/G cg11764359 chr7:65958608 NA 0.45 5.63 0.3 3.81e-8 Aortic root size; CRC cis rs6831352 0.918 rs17217949 chr4:100054312 A/G cg12011299 chr4:100065546 ADH4 -0.49 -9.27 -0.45 2.61e-18 Alcohol dependence; CRC cis rs13256369 1.000 rs1109619 chr8:8571616 G/T cg17143192 chr8:8559678 CLDN23 0.46 6.07 0.32 3.45e-9 Obesity-related traits; CRC cis rs1046896 0.520 rs9895409 chr17:80902719 C/T cg16060761 chr17:80687452 NA -0.49 -6.62 -0.34 1.44e-10 Glycated hemoglobin levels; CRC cis rs4253772 0.591 rs6007727 chr22:46650959 G/A cg09491104 chr22:46646882 C22orf40 -0.48 -7.51 -0.38 5.72e-13 LDL cholesterol;Cholesterol, total; CRC trans rs1814175 0.645 rs11040703 chr11:50024961 C/T cg11707556 chr5:10655725 ANKRD33B -0.52 -10.25 -0.49 1.36e-21 Height; CRC cis rs67311347 0.784 rs13326389 chr3:40459724 A/G cg09455208 chr3:40491958 NA 0.5 10.0 0.48 9.66e-21 Renal cell carcinoma; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg08431062 chr19:16607243 C19orf44;CALR3 0.43 6.07 0.32 3.56e-9 Response to antipsychotic treatment; CRC cis rs2658782 1.000 rs2658778 chr11:93148948 C/G cg21115391 chr11:93143810 CCDC67 -0.4 -5.87 -0.31 1.07e-8 Pulmonary function decline; CRC cis rs41271473 0.526 rs1925720 chr1:228728377 G/C cg16512390 chr1:228756714 NA 0.64 6.72 0.35 7.95e-11 Chronic lymphocytic leukemia; CRC cis rs6748734 1.000 rs7604393 chr2:241825034 T/G cg16358738 chr2:241808595 AGXT -0.4 -6.02 -0.31 4.76e-9 Urinary metabolites; CRC cis rs853679 0.517 rs35227624 chr6:28132726 A/G cg23161317 chr6:28129485 ZNF389 0.53 6.43 0.33 4.52e-10 Depression; CRC cis rs9682041 0.696 rs6774380 chr3:170091644 T/A cg11886554 chr3:170076028 SKIL 0.69 8.23 0.41 4.47e-15 Glomerular filtration rate in non diabetics (creatinine);Glomerular filtration rate (creatinine); CRC cis rs3731896 0.848 rs4485556 chr2:220157418 A/C cg00496455 chr2:220118770 TUBA4A;TUBA4B 0.52 5.93 0.31 7.82e-9 Educational attainment; CRC cis rs62158211 0.565 rs57611236 chr2:114103804 A/T cg17784749 chr2:114082611 LOC440839 0.45 5.83 0.31 1.32e-8 Sleep duration (oversleepers vs undersleepers);Sleep traits (multi-trait analysis);Sleep duration; CRC cis rs1003719 0.715 rs2835658 chr21:38565201 A/G cg10648535 chr21:38446584 PIGP;TTC3 -0.47 -6.47 -0.34 3.46e-10 Eye color traits; CRC cis rs11758351 1.000 rs77961951 chr6:26186075 A/G cg22723502 chr6:26240528 HIST1H4F -0.43 -6.46 -0.34 3.78e-10 Gout;Renal underexcretion gout; CRC trans rs2303319 0.504 rs12467625 chr2:162603387 C/A cg09481857 chr22:21368659 P2RX6;MGC16703 -0.65 -6.31 -0.33 9.13e-10 Cognitive function; CRC trans rs79976124 0.797 rs79522358 chr6:66641140 C/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.76 9.55 0.47 3.03e-19 Type 2 diabetes; CRC cis rs6540556 0.723 rs7539852 chr1:209898539 A/G cg23920097 chr1:209922102 NA -0.48 -5.62 -0.3 4.1e-8 Red blood cell count; CRC cis rs711245 0.518 rs11886145 chr2:36825716 C/G cg01206211 chr2:36825736 FEZ2 0.66 11.75 0.54 7.44e-27 Height; CRC cis rs2840044 0.534 rs2124246 chr17:33885431 G/A cg05299278 chr17:33885742 SLFN14 0.52 8.54 0.43 5.1e-16 Response to radiotherapy in cancer (late toxicity); CRC cis rs11252926 0.537 rs4554800 chr10:458477 G/T cg16386425 chr10:429943 DIP2C 0.43 6.61 0.34 1.53e-10 Psychosis in Alzheimer's disease; CRC cis rs371025208 1 rs371025208 chr20:43928602 TGGGTGTGTGTGTGTAGGG/T cg06407657 chr20:43937138 MATN4;RBPJL 0.41 6.43 0.33 4.61e-10 Parental longevity (mother's age at death); CRC cis rs7408868 0.611 rs11669982 chr19:15292366 C/T cg14696996 chr19:15285081 NOTCH3 0.53 6.2 0.32 1.71e-9 Pulse pressure; CRC cis rs11190604 0.767 rs4919459 chr10:102200371 C/T cg16342193 chr10:102329863 NA -0.36 -5.89 -0.31 9.47e-9 Palmitoleic acid (16:1n-7) levels; CRC cis rs2070488 0.965 rs35553573 chr3:38441439 C/T cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.9 16.56 0.67 3.28e-45 Electrocardiographic conduction measures; CRC cis rs921968 0.643 rs598701 chr2:219387005 C/G cg02176678 chr2:219576539 TTLL4 -0.48 -7.71 -0.39 1.56e-13 Mean corpuscular hemoglobin concentration; CRC cis rs2737618 0.651 rs2816975 chr1:200081159 A/G cg21825944 chr1:200113062 NR5A2 -0.48 -7.17 -0.37 5.09e-12 Uric acid levels; CRC cis rs7202877 0.610 rs8053632 chr16:75364940 C/T cg03315344 chr16:75512273 CHST6 0.48 5.84 0.31 1.27e-8 Type 2 diabetes;Type 1 diabetes; CRC cis rs17767392 0.871 rs34347034 chr14:71935513 G/A cg13720639 chr14:72061746 SIPA1L1 -0.56 -7.17 -0.37 5.11e-12 Mitral valve prolapse; CRC cis rs9463078 0.874 rs7743116 chr6:45142858 T/C cg25276700 chr6:44698697 NA -0.29 -6.81 -0.35 4.57e-11 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; CRC trans rs35110281 0.563 rs162371 chr21:44931489 G/T cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.46 7.5 0.38 5.82e-13 Mean corpuscular volume; CRC cis rs12541335 0.590 rs11136002 chr8:22217082 C/T cg26039829 chr8:22132926 PIWIL2 0.53 9.42 0.46 8.34e-19 Hypertriglyceridemia; CRC cis rs2839186 0.872 rs13046834 chr21:47701485 T/C cg09417038 chr21:47716443 C21orf57 -0.41 -6.8 -0.35 4.94e-11 Testicular germ cell tumor; CRC cis rs898097 0.691 rs7222773 chr17:80907283 A/G cg15664640 chr17:80829946 TBCD 0.49 8.19 0.41 5.89e-15 Breast cancer; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg08860546 chr16:4233762 NA -0.42 -6.18 -0.32 1.94e-9 Myopia (pathological); CRC cis rs7937682 0.921 rs7130753 chr11:111470567 C/T cg19812747 chr11:111475976 SIK2 0.53 7.62 0.39 2.78e-13 Primary sclerosing cholangitis; CRC cis rs6500395 1.000 rs11076578 chr16:48714520 C/G cg04672837 chr16:48644449 N4BP1 -0.45 -6.63 -0.34 1.38e-10 Response to tocilizumab in rheumatoid arthritis; CRC cis rs7107174 1.000 rs1485483 chr11:77930138 T/C cg02023728 chr11:77925099 USP35 0.51 7.35 0.38 1.59e-12 Testicular germ cell tumor; CRC cis rs57221529 0.766 rs72703064 chr5:587825 T/C cg09021430 chr5:549028 NA -0.72 -7.85 -0.4 5.75e-14 Lung disease severity in cystic fibrosis; CRC cis rs826838 0.967 rs11168299 chr12:38902028 G/T cg26384229 chr12:38710491 ALG10B 0.75 10.41 0.5 3.99e-22 Heart rate; CRC cis rs1862618 0.620 rs189695 chr5:56225769 T/C cg24531977 chr5:56204891 C5orf35 -0.68 -10.3 -0.49 9.57e-22 Initial pursuit acceleration; CRC cis rs3820068 0.822 rs2901964 chr1:15792426 C/G cg27534772 chr1:16042836 PLEKHM2 0.37 6.34 0.33 7.43e-10 Systolic blood pressure; CRC cis rs9322193 0.923 rs35961297 chr6:149989065 T/C cg07701084 chr6:150067640 NUP43 0.56 8.25 0.41 3.79e-15 Lung cancer; CRC cis rs7959452 0.590 rs11177619 chr12:69758871 G/A cg20891283 chr12:69753455 YEATS4 0.91 17.38 0.69 1.84e-48 Blood protein levels; CRC cis rs66887589 0.616 rs11731675 chr4:120212514 T/C cg09307838 chr4:120376055 NA 0.56 8.59 0.43 3.57e-16 Diastolic blood pressure; CRC cis rs2949837 0.603 rs1542818 chr7:45977656 G/T cg23193639 chr7:45961078 IGFBP3 0.4 6.66 0.34 1.14e-10 Sitting height ratio; CRC cis rs1003719 0.788 rs8133549 chr21:38447489 C/T cg10648535 chr21:38446584 PIGP;TTC3 0.53 7.58 0.39 3.56e-13 Eye color traits; CRC cis rs4478858 0.684 rs7515988 chr1:31731061 C/T cg00250761 chr1:31883323 NA 0.46 9.09 0.45 9.87e-18 Alcohol dependence; CRC cis rs75804782 0.641 rs11904390 chr2:239344663 T/A cg18131467 chr2:239335373 ASB1 -0.71 -6.32 -0.33 8.61e-10 Morning vs. evening chronotype;Chronotype; CRC cis rs7618501 0.602 rs2624853 chr3:50128893 A/G cg05623727 chr3:50126028 RBM5 -0.44 -7.47 -0.38 7.28e-13 Intelligence (multi-trait analysis); CRC cis rs1707322 1.000 rs11211244 chr1:46456673 G/A cg06784218 chr1:46089804 CCDC17 0.52 9.22 0.45 3.7e-18 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs9916302 0.851 rs12936996 chr17:37665554 A/G cg15445000 chr17:37608096 MED1 -0.42 -9.26 -0.45 2.8e-18 Glomerular filtration rate (creatinine); CRC cis rs7264396 0.790 rs6058290 chr20:34247702 G/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.59 -9.84 -0.48 3.48e-20 Total cholesterol levels; CRC cis rs4481887 0.927 rs4282853 chr1:248475127 A/G cg13385794 chr1:248469461 NA 0.38 6.65 0.34 1.26e-10 Common traits (Other); CRC cis rs10504229 0.593 rs16921626 chr8:58040359 C/T cg02725872 chr8:58115012 NA -0.41 -6.38 -0.33 6.05e-10 Developmental language disorder (linguistic errors); CRC cis rs2153535 0.580 rs4960412 chr6:8438261 G/C cg07606381 chr6:8435919 SLC35B3 0.68 10.89 0.51 8.99e-24 Motion sickness; CRC cis rs972578 0.747 rs5758975 chr22:43233265 C/T cg01576275 chr22:43409880 NA -0.39 -6.1 -0.32 2.99e-9 Mean platelet volume; CRC cis rs10504229 0.683 rs7838958 chr8:58136968 T/C cg24829409 chr8:58192753 C8orf71 -0.55 -8.03 -0.4 1.71e-14 Developmental language disorder (linguistic errors); CRC cis rs1403694 0.515 rs1622922 chr3:186449884 C/T cg04611788 chr3:186434169 KNG1 -0.57 -8.32 -0.42 2.41e-15 Blood protein levels; CRC trans rs1814175 0.647 rs28456013 chr11:50047629 T/C cg21153622 chr11:89784906 NA -0.43 -6.99 -0.36 1.58e-11 Height; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg17839278 chr11:47664375 MTCH2 0.45 6.11 0.32 2.77e-9 Response to antipsychotic treatment; CRC cis rs67478160 0.643 rs8005225 chr14:104300151 C/T cg01849466 chr14:104193079 ZFYVE21 0.5 9.07 0.45 1.13e-17 Schizophrenia; CRC cis rs11190604 0.725 rs9420796 chr10:102323092 G/C cg07080220 chr10:102295463 HIF1AN 0.49 6.2 0.32 1.7e-9 Palmitoleic acid (16:1n-7) levels; CRC cis rs28386778 0.897 rs968719 chr17:61908271 C/T cg23090583 chr17:61904693 PSMC5;FTSJ3 1.06 18.73 0.72 8.35e-54 Prudent dietary pattern; CRC cis rs546131 0.928 rs572690 chr11:34833614 A/G cg11058730 chr11:34937778 PDHX;APIP 0.48 7.02 0.36 1.24e-11 Lung disease severity in cystic fibrosis; CRC cis rs6964587 1.000 rs6465343 chr7:91618208 T/C cg17063962 chr7:91808500 NA 0.83 14.72 0.63 5.05e-38 Breast cancer; CRC cis rs2624839 0.704 rs14321 chr3:50226151 T/C cg05623727 chr3:50126028 RBM5 -0.4 -5.96 -0.31 6.35e-9 Intelligence (multi-trait analysis); CRC cis rs2404602 0.583 rs12898415 chr15:76574232 C/T cg23625390 chr15:77176239 SCAPER 0.39 5.61 0.3 4.33e-8 Blood metabolite levels; CRC cis rs11098499 0.954 rs17009122 chr4:120362403 G/A cg24375607 chr4:120327624 NA 0.51 7.98 0.4 2.49e-14 Corneal astigmatism; CRC cis rs3820068 0.603 rs932602 chr1:15986087 A/G cg24675056 chr1:15929824 NA 0.54 7.31 0.37 2.07e-12 Systolic blood pressure; CRC cis rs11077998 0.935 rs11653926 chr17:80484953 G/A cg10255544 chr17:80519551 FOXK2 0.4 6.24 0.33 1.37e-9 Reticulocyte fraction of red cells; CRC cis rs1862618 0.802 rs4389648 chr5:56103602 A/G cg18230493 chr5:56204884 C5orf35 -0.75 -9.49 -0.46 4.75e-19 Initial pursuit acceleration; CRC cis rs6951245 0.872 rs75398423 chr7:1098414 T/G cg22907277 chr7:1156413 C7orf50 0.73 7.68 0.39 1.78e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs4727027 0.704 rs7784122 chr7:148904624 A/G cg23583168 chr7:148888333 NA 0.91 17.17 0.69 1.3e-47 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC cis rs11690935 0.632 rs6737308 chr2:172872042 G/A cg13550731 chr2:172543902 DYNC1I2 0.65 9.31 0.46 1.84e-18 Schizophrenia; CRC trans rs9388451 0.868 rs1268083 chr6:126049040 T/C cg05039488 chr6:79577232 IRAK1BP1 0.57 8.92 0.44 3.33e-17 Brugada syndrome; CRC cis rs9443645 0.545 rs10755377 chr6:79637925 T/C cg05283184 chr6:79620031 NA -0.43 -6.32 -0.33 8.48e-10 Intelligence (multi-trait analysis); CRC cis rs11212617 0.967 rs189037 chr11:108093833 G/A cg01991180 chr11:108092276 ATM;NPAT 0.4 5.66 0.3 3.26e-8 Response to metformin in type 2 diabetes (glycemic); CRC trans rs61931739 0.500 rs11053211 chr12:34464334 T/C cg26384229 chr12:38710491 ALG10B 0.62 9.06 0.45 1.16e-17 Morning vs. evening chronotype; CRC trans rs2228479 0.702 rs62052710 chr16:89854893 C/T cg24644049 chr4:85504048 CDS1 0.93 7.58 0.39 3.6e-13 Skin colour saturation; CRC cis rs6089584 0.888 rs6061973 chr20:60610870 C/T cg13770153 chr20:60521292 NA -0.55 -8.22 -0.41 4.82e-15 Body mass index; CRC cis rs11098499 0.909 rs73842633 chr4:120375464 G/A cg09307838 chr4:120376055 NA 0.71 10.95 0.52 5.2e-24 Corneal astigmatism; CRC cis rs4713118 0.824 rs2179095 chr6:27750858 A/G cg08798685 chr6:27730294 NA 0.53 7.53 0.38 5.09e-13 Parkinson's disease; CRC cis rs9902453 0.935 rs4310926 chr17:28433275 A/G cg26525008 chr17:28256777 EFCAB5;SSH2 0.68 10.96 0.52 5.08e-24 Coffee consumption (cups per day); CRC cis rs4713118 0.513 rs149972 chr6:27983227 C/T cg25164649 chr6:28176230 NA 0.62 8.92 0.44 3.23e-17 Parkinson's disease; CRC cis rs2688482 0.512 rs3103953 chr3:195520597 G/A cg12923728 chr3:195709715 SDHAP1 0.6 6.29 0.33 1.03e-9 Lung disease severity in cystic fibrosis; CRC cis rs7429990 0.932 rs6766641 chr3:48145224 G/A cg11946769 chr3:48343235 NME6 -0.5 -6.59 -0.34 1.75e-10 Educational attainment (years of education); CRC cis rs2799081 1 rs2799081 chr6:28270584 T/C cg15845792 chr6:28175446 NA 0.44 5.74 0.3 2.15e-8 Myopia; CRC cis rs10760158 0.832 rs10818519 chr9:124012935 G/C cg14417974 chr9:124058376 GSN -0.34 -5.7 -0.3 2.62e-8 Pulse pressure; CRC cis rs9894429 0.572 rs112417725 chr17:79578219 A/G cg21984481 chr17:79567631 NPLOC4 0.46 8.0 0.4 2.21e-14 Eye color traits; CRC cis rs2153535 0.601 rs2327054 chr6:8443130 T/C cg21535247 chr6:8435926 SLC35B3 0.49 7.27 0.37 2.65e-12 Motion sickness; CRC cis rs60843830 0.661 rs62116681 chr2:104197 A/T cg00108164 chr2:264199 ACP1;SH3YL1 0.41 5.66 0.3 3.27e-8 Spherical equivalent (joint analysis main effects and education interaction); CRC cis rs4665809 0.793 rs6546715 chr2:26261520 G/A cg04944784 chr2:26401820 FAM59B -0.58 -7.52 -0.38 5.39e-13 Gut microbiome composition (summer); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg21051031 chr5:93905482 C5orf36;MIR1974 -0.36 -5.99 -0.31 5.6e-9 Liver disease severity in Alagille syndrome; CRC cis rs9768139 0.733 rs13309363 chr7:158122179 C/A cg23298862 chr7:158159286 PTPRN2 0.39 6.05 0.32 3.99e-9 Calcium levels; CRC trans rs877282 1.000 rs34257857 chr10:772993 C/A cg22713356 chr15:30763199 NA 1.15 14.73 0.63 4.62e-38 Uric acid levels; CRC cis rs561341 0.941 rs7215147 chr17:30266711 G/A cg00745463 chr17:30367425 LRRC37B -0.62 -7.89 -0.4 4.65e-14 Hip circumference adjusted for BMI; CRC cis rs2274273 0.615 rs17672058 chr14:55673394 C/T cg10130446 chr14:55658398 DLGAP5 -0.43 -5.81 -0.31 1.46e-8 Protein biomarker; CRC cis rs311392 0.867 rs434952 chr8:55091998 C/T cg20636351 chr8:55087400 NA -0.33 -5.96 -0.31 6.62e-9 Pelvic organ prolapse (moderate/severe); CRC cis rs2842992 0.789 rs2342446 chr6:160220687 A/G cg16489826 chr6:160211363 TCP1;MRPL18 0.49 6.14 0.32 2.32e-9 Age-related macular degeneration (geographic atrophy); CRC cis rs1018836 0.786 rs7016220 chr8:91606848 A/G cg16814680 chr8:91681699 NA -0.69 -10.51 -0.5 1.77e-22 Ejection fraction in Tripanosoma cruzi seropositivity; CRC cis rs77633900 0.772 rs79181196 chr15:76656281 G/T cg21673338 chr15:77095150 SCAPER -0.74 -6.88 -0.35 3e-11 Non-glioblastoma glioma;Glioma; CRC cis rs28493229 0.708 rs10407431 chr19:41160870 T/C cg21869046 chr19:41225005 ITPKC 0.41 6.15 0.32 2.26e-9 Kawasaki disease; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg23781003 chr4:120988207 MAD2L1 0.51 7.32 0.37 1.98e-12 Response to antipsychotic treatment; CRC cis rs2050392 1.000 rs2253585 chr10:30696503 C/T cg18806716 chr10:30721971 MAP3K8 -0.47 -7.18 -0.37 4.58e-12 Inflammatory bowel disease; CRC cis rs10504229 0.683 rs7820302 chr8:58142502 C/T cg04204079 chr8:58130323 NA -0.42 -5.66 -0.3 3.32e-8 Developmental language disorder (linguistic errors); CRC trans rs61931739 0.500 rs7133447 chr12:34041901 A/G cg26384229 chr12:38710491 ALG10B 0.47 6.36 0.33 6.58e-10 Morning vs. evening chronotype; CRC cis rs2439831 0.850 rs28564774 chr15:44125475 G/C cg02155558 chr15:43621948 ADAL;LCMT2 0.69 7.46 0.38 7.65e-13 Lung cancer in ever smokers; CRC trans rs2243480 1.000 rs67728539 chr7:65378124 G/A cg10756647 chr7:56101905 PSPH 0.73 7.83 0.4 6.99e-14 Diabetic kidney disease; CRC cis rs17155006 0.612 rs435361 chr7:107738552 C/T cg05962710 chr7:107745446 LAMB4 -0.43 -7.53 -0.38 4.79e-13 Pneumococcal bacteremia; CRC cis rs3820068 0.532 rs74057713 chr1:15944620 G/C cg27534772 chr1:16042836 PLEKHM2 0.54 10.62 0.51 7.47e-23 Systolic blood pressure; CRC cis rs1519814 1.000 rs4871037 chr8:121124042 A/G cg22335954 chr8:121166405 COL14A1 -0.55 -6.25 -0.33 1.25e-9 Breast cancer; CRC cis rs289828 0.868 rs289829 chr2:152136901 A/G cg06191203 chr2:152266755 RIF1 -0.4 -5.69 -0.3 2.87e-8 Blood protein levels; CRC cis rs12024301 0.557 rs12040169 chr1:183639963 C/T cg11505048 chr1:183622726 RGL1;APOBEC4 0.79 6.98 0.36 1.59e-11 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs7647973 1.000 rs11720542 chr3:49357427 A/G cg20833759 chr3:49053208 WDR6;DALRD3 0.53 8.0 0.4 2.12e-14 Menarche (age at onset); CRC cis rs6933660 0.646 rs3736176 chr6:151773320 T/A cg14416726 chr6:151773293 C6orf211;RMND1 -0.77 -12.76 -0.58 1.49e-30 Menarche (age at onset); CRC cis rs875971 0.638 rs801205 chr7:66022144 C/A cg18876405 chr7:65276391 NA -0.61 -10.95 -0.52 5.42e-24 Aortic root size; CRC cis rs9611565 0.694 rs5758347 chr22:41821019 G/T cg06481639 chr22:41940642 POLR3H 0.51 5.63 0.3 3.96e-8 Vitiligo; CRC cis rs16870629 0.541 rs2334955 chr5:1062444 A/G cg00278107 chr5:1061253 SLC12A7 -0.82 -13.21 -0.59 2.86e-32 QT interval; CRC cis rs7786808 0.525 rs10253961 chr7:158194858 G/A cg17401720 chr7:158221031 PTPRN2 -0.4 -6.67 -0.35 1.06e-10 Obesity-related traits; CRC cis rs1218582 0.661 rs4845695 chr1:154911798 A/G cg06221963 chr1:154839813 KCNN3 -0.78 -13.78 -0.61 1.99e-34 Prostate cancer; CRC trans rs6703335 0.870 rs10803142 chr1:243598234 A/G cg03309838 chr22:41215494 SLC25A17 0.44 6.35 0.33 7.21e-10 Schizophrenia;Schizophrenia, schizoaffective disorder or bipolar disorder; CRC cis rs394563 0.690 rs237010 chr6:149758750 G/T cg11245181 chr6:149772854 ZC3H12D -0.58 -10.47 -0.5 2.56e-22 Dupuytren's disease; CRC cis rs17666538 0.535 rs7822126 chr8:643810 A/G cg02524346 chr8:600233 NA 0.72 7.67 0.39 2.01e-13 IgG glycosylation; CRC cis rs72615157 0.606 rs941288 chr7:99776808 G/A cg19337854 chr7:99768885 GPC2 0.43 5.6 0.3 4.47e-8 Lung function (FEV1/FVC); CRC trans rs11148252 0.514 rs3783242 chr13:52717950 C/T cg18335740 chr13:41363409 SLC25A15 0.48 7.09 0.36 8.44e-12 Lewy body disease; CRC cis rs58688157 0.705 rs36060383 chr11:598723 A/C cg01842473 chr11:617407 IRF7;MUPCDH -0.55 -6.58 -0.34 1.88e-10 Systemic lupus erythematosus; CRC cis rs9322817 0.691 rs4591886 chr6:105249970 G/C cg02098413 chr6:105308735 HACE1 -0.44 -8.6 -0.43 3.29e-16 Thyroid stimulating hormone; CRC cis rs972578 0.967 rs2068944 chr22:43356442 T/G cg01576275 chr22:43409880 NA -0.46 -7.41 -0.38 1.08e-12 Mean platelet volume; CRC trans rs7618501 1.000 rs6775384 chr3:49853073 G/A cg21665057 chr3:196295764 WDR53;FBXO45 0.81 14.76 0.63 3.61e-38 Intelligence (multi-trait analysis); CRC cis rs12188164 0.714 rs11741954 chr5:421455 G/T cg21972741 chr5:435613 AHRR 0.5 6.74 0.35 6.96e-11 Cystic fibrosis severity; CRC cis rs9916302 0.645 rs1053651 chr17:37822311 A/C cg15445000 chr17:37608096 MED1 0.26 5.71 0.3 2.54e-8 Glomerular filtration rate (creatinine); CRC cis rs1707322 0.964 rs10437063 chr1:46273666 G/A cg06784218 chr1:46089804 CCDC17 0.51 8.99 0.44 1.92e-17 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC trans rs7395662 0.963 rs2135681 chr11:48728388 T/C cg21153622 chr11:89784906 NA -0.48 -7.72 -0.39 1.45e-13 HDL cholesterol; CRC cis rs2880765 0.743 rs4551990 chr15:86015287 A/C cg17133734 chr15:86042851 AKAP13 0.39 6.06 0.32 3.78e-9 Coronary artery disease; CRC cis rs832540 0.669 rs832538 chr5:56200016 C/T cg03609598 chr5:56110824 MAP3K1 -0.56 -7.68 -0.39 1.86e-13 Coronary artery disease; CRC cis rs10489202 0.632 rs6659713 chr1:168072249 G/T cg24449463 chr1:168025552 DCAF6 0.51 7.35 0.38 1.57e-12 Schizophrenia; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg03352409 chr22:21336370 LZTR1 0.54 7.1 0.36 7.52e-12 Thyroid stimulating hormone; CRC cis rs7762018 0.607 rs80106119 chr6:170048309 T/C cg19338460 chr6:170058176 WDR27 -1.25 -10.26 -0.49 1.27e-21 Thiazide-induced adverse metabolic effects in hypertensive patients; CRC cis rs61008539 0.853 rs10950611 chr7:861094 G/T cg15782153 chr7:917662 C7orf20 0.48 7.76 0.39 1.06e-13 Perceived unattractiveness to mosquitoes; CRC cis rs875971 0.545 rs2279757 chr7:65828663 T/C cg05627663 chr7:65219948 SNORA22;CCT6P1 0.62 7.92 0.4 3.58e-14 Aortic root size; CRC cis rs12188164 0.965 rs72717435 chr5:448202 G/A cg17553881 chr5:443987 EXOC3;C5orf55 -0.37 -7.81 -0.4 7.64e-14 Cystic fibrosis severity; CRC trans rs4650994 0.544 rs6675811 chr1:178499068 T/A cg27649806 chr9:35101217 STOML2 0.38 6.08 0.32 3.37e-9 HDL cholesterol levels;HDL cholesterol; CRC cis rs9488822 0.676 rs12202641 chr6:116314634 A/G cg05304507 chr6:116381966 FRK -0.3 -8.07 -0.41 1.34e-14 Cholesterol, total;LDL cholesterol; CRC cis rs826838 0.874 rs11183816 chr12:38834656 T/G cg26384229 chr12:38710491 ALG10B 0.75 10.46 0.5 2.69e-22 Heart rate; CRC cis rs1506636 0.962 rs1019220 chr7:123365122 G/A cg03229431 chr7:123269106 ASB15 -0.74 -11.75 -0.54 7.63e-27 Plateletcrit;Platelet count; CRC cis rs1223397 0.651 rs2496149 chr6:13313893 A/G cg07912922 chr6:13274314 PHACTR1 0.37 5.78 0.3 1.71e-8 Blood pressure; CRC cis rs798554 0.679 rs2533870 chr7:2885274 C/G cg13628971 chr7:2884303 GNA12 -0.59 -8.23 -0.41 4.32e-15 Height; CRC cis rs9322193 0.923 rs7740278 chr6:149961252 C/T cg13206674 chr6:150067644 NUP43 0.65 9.76 0.47 6.33e-20 Lung cancer; CRC cis rs13108904 0.935 rs1620928 chr4:1279124 C/T cg16405210 chr4:1374714 KIAA1530 0.45 6.4 0.33 5.39e-10 Obesity-related traits; CRC cis rs7727544 0.654 rs4705849 chr5:131559199 T/A cg14196790 chr5:131705035 SLC22A5 0.35 6.07 0.32 3.46e-9 Blood metabolite levels; CRC cis rs9811920 0.809 rs796976 chr3:99621002 G/A cg07805332 chr3:99536008 MIR548G;C3orf26 -0.39 -6.08 -0.32 3.35e-9 Axial length; CRC cis rs9911578 0.934 rs8081967 chr17:57072701 T/C cg05425664 chr17:57184151 TRIM37 -0.54 -8.45 -0.42 9.73e-16 Intelligence (multi-trait analysis); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg22658884 chr19:14192470 NA 0.46 6.39 0.33 5.62e-10 Response to antipsychotic treatment; CRC cis rs9322193 0.962 rs35031906 chr6:149998574 T/C cg07701084 chr6:150067640 NUP43 0.46 6.55 0.34 2.17e-10 Lung cancer; CRC cis rs6752107 0.936 rs10192702 chr2:234206750 A/C cg07618928 chr2:234183455 ATG16L1;SCARNA5 0.59 9.71 0.47 9.45e-20 Crohn's disease;Inflammatory bowel disease; CRC cis rs12024301 0.557 rs12029723 chr1:183594236 G/C cg11505048 chr1:183622726 RGL1;APOBEC4 0.76 6.93 0.36 2.16e-11 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs12142240 0.698 rs1475389 chr1:46816429 T/C cg00530320 chr1:46809349 NSUN4 0.57 7.75 0.39 1.19e-13 Menopause (age at onset); CRC cis rs12594515 1.000 rs11070464 chr15:45984776 C/A cg06207120 chr15:45996521 NA 0.32 7.72 0.39 1.38e-13 Waist circumference;Weight; CRC cis rs11785400 0.793 rs4457308 chr8:143733922 G/A cg10596483 chr8:143751796 JRK 0.47 6.47 0.34 3.46e-10 Schizophrenia; CRC cis rs4713118 0.591 rs2056924 chr6:27690174 G/A cg08798685 chr6:27730294 NA -0.38 -5.67 -0.3 3.16e-8 Parkinson's disease; CRC cis rs7647973 0.516 rs4955418 chr3:49200627 A/G cg20833759 chr3:49053208 WDR6;DALRD3 0.4 6.44 0.33 4.22e-10 Menarche (age at onset); CRC cis rs59104589 0.517 rs15129 chr2:242168976 T/C cg19488206 chr2:242435732 STK25 0.39 5.96 0.31 6.49e-9 Fibrinogen levels; CRC cis rs294883 0.858 rs1553481 chr6:159701771 C/T cg14500486 chr6:159655392 FNDC1 -0.35 -5.75 -0.3 2.09e-8 Coronary artery disease; CRC cis rs17270561 0.636 rs11794 chr6:25701718 G/A cg17691542 chr6:26056736 HIST1H1C 0.69 8.53 0.43 5.51e-16 Iron status biomarkers; CRC cis rs8072100 0.713 rs11079776 chr17:45546893 C/T cg25173405 chr17:45401733 C17orf57 -0.42 -6.4 -0.33 5.3e-10 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs853679 0.517 rs9368553 chr6:28082265 T/C cg02631126 chr6:28058918 ZSCAN12L1 0.29 5.87 0.31 1.05e-8 Depression; CRC trans rs11098499 0.722 rs28713555 chr4:120251995 C/T cg25214090 chr10:38739885 LOC399744 0.53 8.36 0.42 1.81e-15 Corneal astigmatism; CRC cis rs6500395 1.000 rs7188741 chr16:48607966 T/C cg04672837 chr16:48644449 N4BP1 0.45 6.65 0.34 1.25e-10 Response to tocilizumab in rheumatoid arthritis; CRC cis rs8077889 0.917 rs58283314 chr17:41905963 T/G cg25876840 chr17:41920477 NA 0.53 7.92 0.4 3.77e-14 Triglycerides; CRC cis rs7659604 0.518 rs17452156 chr4:122733623 T/C cg23574427 chr4:122746245 BBS7;CCNA2 -0.3 -5.64 -0.3 3.66e-8 Type 2 diabetes; CRC cis rs4711350 0.953 rs1547668 chr6:33775446 A/G cg07979401 chr6:33739406 LEMD2 -0.47 -6.0 -0.31 5.11e-9 Schizophrenia; CRC cis rs10504229 0.638 rs6981055 chr8:58113941 T/C cg02290350 chr8:58132656 NA -0.58 -8.24 -0.41 4.09e-15 Developmental language disorder (linguistic errors); CRC cis rs73206853 0.841 rs67974983 chr12:110519237 T/G cg12870014 chr12:110450643 ANKRD13A 0.74 8.75 0.43 1.14e-16 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg05926606 chr21:40685342 BRWD1 -0.42 -6.29 -0.33 1.01e-9 Myopia (pathological); CRC cis rs3096299 0.685 rs4785676 chr16:89553624 T/C cg01788221 chr16:89496183 ANKRD11 -0.38 -5.63 -0.3 3.84e-8 Multiple myeloma (IgH translocation); CRC cis rs3751196 0.908 rs12423476 chr12:104210442 C/G cg02344784 chr12:104178138 NT5DC3 0.69 8.58 0.43 3.93e-16 Sense of smell; CRC cis rs1552244 0.572 rs67439440 chr3:10169503 C/T cg08888203 chr3:10149979 C3orf24 0.71 8.58 0.43 3.91e-16 Alzheimer's disease; CRC trans rs703108 0.731 rs7898954 chr10:22323646 A/G cg17295864 chr8:62381505 CLVS1 -0.54 -6.68 -0.35 9.96e-11 Monocyte percentage of white cells; CRC trans rs35110281 0.774 rs9978811 chr21:44998683 C/T cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.43 6.97 0.36 1.74e-11 Mean corpuscular volume; CRC cis rs9325144 0.647 rs11169222 chr12:39105210 C/T cg26384229 chr12:38710491 ALG10B -0.52 -7.34 -0.37 1.74e-12 Morning vs. evening chronotype; CRC cis rs12477438 0.677 rs12475034 chr2:99699464 A/G cg14399236 chr2:99771627 LIPT1;TSGA10 -0.65 -7.94 -0.4 3.14e-14 Chronic sinus infection; CRC cis rs2274471 0.591 rs7034539 chr9:5081585 C/T cg03390472 chr9:5043263 JAK2 0.59 7.15 0.37 5.67e-12 Crohn's disease; CRC cis rs9549328 0.800 rs9549616 chr13:113627762 T/G cg16822035 chr13:113633379 MCF2L -0.29 -5.91 -0.31 8.49e-9 Systolic blood pressure; CRC cis rs6674970 0.748 rs56299877 chr1:151115645 C/T cg11822372 chr1:151115635 SEMA6C -0.84 -11.47 -0.53 7.38e-26 Childhood ear infection; CRC cis rs6921919 0.789 rs1119211 chr6:28309136 C/G cg21251018 chr6:28226885 NKAPL -0.42 -6.31 -0.33 8.9e-10 Autism spectrum disorder or schizophrenia; CRC cis rs875971 0.862 rs10256544 chr7:65675128 A/G cg12463550 chr7:65579703 CRCP 0.51 7.25 0.37 3.09e-12 Aortic root size; CRC cis rs1448094 0.511 rs59668915 chr12:86197170 C/T cg02569458 chr12:86230093 RASSF9 0.44 7.61 0.39 2.88e-13 Major depressive disorder; CRC cis rs9291683 0.530 rs6449196 chr4:9973660 C/T cg00071950 chr4:10020882 SLC2A9 -0.65 -12.04 -0.55 6.65e-28 Bone mineral density; CRC cis rs4073582 1.000 rs801732 chr11:65935502 T/A cg14036092 chr11:66035641 RAB1B 0.55 7.8 0.4 8.29e-14 Gout; CRC cis rs1971762 0.545 rs9788134 chr12:54046067 A/T cg06632207 chr12:54070931 ATP5G2 0.5 8.79 0.44 8.18e-17 Height; CRC cis rs9467711 0.651 rs34116162 chr6:25937652 G/A cg16898833 chr6:26189333 HIST1H4D 0.72 6.01 0.31 5.01e-9 Autism spectrum disorder or schizophrenia; CRC cis rs7811142 0.943 rs67196635 chr7:100025564 T/C cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.62 8.34 0.42 2.01e-15 Platelet count; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg08143133 chr22:32598570 RFPL2 0.49 7.56 0.38 4.03e-13 Liver disease severity in Alagille syndrome; CRC cis rs7212590 0.618 rs7217337 chr17:58023417 C/T cg10252138 chr17:58120427 NA -0.58 -6.28 -0.33 1.1e-9 Granulocyte percentage of myeloid white cells;Monocyte count;Monocyte percentage of white cells; CRC cis rs7945705 0.869 rs7925728 chr11:9013002 A/G cg12365402 chr11:9010492 NRIP3 -0.58 -10.54 -0.5 1.37e-22 Hemoglobin concentration; CRC cis rs4594175 0.926 rs12432356 chr14:51631223 T/G cg23942311 chr14:51606299 NA 0.63 10.39 0.5 4.86e-22 Cancer; CRC cis rs853679 0.517 rs9393896 chr6:28127703 C/T cg18032046 chr6:28092343 ZSCAN16 -0.51 -5.93 -0.31 7.47e-9 Depression; CRC cis rs743757 1.000 rs2236973 chr3:50474284 T/C cg08207895 chr3:50388901 TUSC4;CYB561D2 0.45 6.59 0.34 1.77e-10 Diastolic blood pressure; CRC cis rs6062302 0.548 rs6089940 chr20:62252695 C/T cg16989086 chr20:62203971 PRIC285 0.51 6.48 0.34 3.36e-10 Glioblastoma; CRC cis rs10256972 0.681 rs6979076 chr7:1116247 C/T cg18402987 chr7:1209562 NA -0.46 -6.82 -0.35 4.43e-11 Longevity;Endometriosis; CRC cis rs12908161 1.000 rs12903134 chr15:85337699 T/A cg17507749 chr15:85114479 UBE2QP1 0.62 8.75 0.43 1.15e-16 Schizophrenia; CRC cis rs7215564 0.818 rs901063 chr17:78595696 A/T cg09596252 chr17:78655493 RPTOR -0.6 -5.71 -0.3 2.48e-8 Myopia (pathological); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg24028120 chr19:33463094 C19orf40;CCDC123 0.42 5.99 0.31 5.4e-9 Response to antipsychotic treatment; CRC cis rs939584 1.000 rs7604609 chr2:643303 C/G cg03610516 chr2:642275 NA 0.4 5.62 0.3 4.1e-8 Body mass index; CRC cis rs6951245 1.000 rs28528096 chr7:1070912 G/C cg20603222 chr7:1096387 C7orf50;GPR146 -0.69 -8.1 -0.41 1.07e-14 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs2180341 0.574 rs13192350 chr6:127677762 G/T cg24812749 chr6:127587940 RNF146 0.63 9.27 0.46 2.51e-18 Breast cancer; CRC cis rs9875589 0.509 rs1488379 chr3:14014719 A/G cg14375111 chr3:14165186 TMEM43;CHCHD4 0.41 5.95 0.31 6.74e-9 Ovarian reserve; CRC cis rs28386778 0.897 rs11654841 chr17:61838259 C/T cg23090583 chr17:61904693 PSMC5;FTSJ3 1.04 20.38 0.75 2.76e-60 Prudent dietary pattern; CRC cis rs6952808 0.792 rs12537914 chr7:1948359 C/T cg04267008 chr7:1944627 MAD1L1 -0.83 -12.55 -0.57 8.82e-30 Bipolar disorder and schizophrenia; CRC cis rs4321325 0.668 rs56346774 chr2:127932551 G/A cg11380483 chr2:127933992 NA 0.65 7.23 0.37 3.33e-12 Protein C levels; CRC cis rs2274273 0.588 rs2880103 chr14:55737832 A/C cg10130446 chr14:55658398 DLGAP5 -0.43 -6.17 -0.32 2.04e-9 Protein biomarker; CRC cis rs1044826 0.642 rs4683464 chr3:139196961 C/T cg00490450 chr3:139108681 COPB2 0.43 6.4 0.33 5.38e-10 Obesity-related traits; CRC cis rs12701220 0.655 rs12702117 chr7:1148702 T/C cg26769984 chr7:1090371 C7orf50 0.55 7.6 0.39 3.08e-13 Bronchopulmonary dysplasia; CRC cis rs2032447 0.798 rs807214 chr6:26061769 G/C cg04800585 chr6:26043546 HIST1H2BB 0.52 7.84 0.4 6.18e-14 Intelligence (multi-trait analysis); CRC trans rs931812 1.000 rs931812 chr8:101919321 A/G cg20993868 chr7:22813445 NA -0.42 -7.85 -0.4 6.03e-14 Attention deficit hyperactivity disorder and conduct disorder; CRC cis rs9894429 0.621 rs9747119 chr17:79607017 A/G cg21028142 chr17:79581711 NPLOC4 0.34 7.06 0.36 1.02e-11 Eye color traits; CRC cis rs1577917 0.920 rs1337842 chr6:86675097 G/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.45 -5.88 -0.31 1.03e-8 Response to antipsychotic treatment; CRC cis rs7666738 0.830 rs4292342 chr4:98959870 A/T cg17366294 chr4:99064904 C4orf37 0.44 7.44 0.38 8.91e-13 Colonoscopy-negative controls vs population controls; CRC cis rs7811142 1.000 rs73161759 chr7:100009994 T/C cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.15 17.19 0.69 1.08e-47 Platelet count; CRC cis rs7772486 0.875 rs2180192 chr6:146322284 T/C cg23711669 chr6:146136114 FBXO30 0.69 11.66 0.54 1.62e-26 Lobe attachment (rater-scored or self-reported); CRC cis rs2411233 0.967 rs6492849 chr15:39271087 T/C cg23129342 chr15:39283510 NA 0.31 5.65 0.3 3.48e-8 Platelet count; CRC cis rs9322193 0.884 rs10872646 chr6:150067675 A/G cg13206674 chr6:150067644 NUP43 0.68 10.28 0.49 1.08e-21 Lung cancer; CRC cis rs7605827 0.930 rs10164574 chr2:15677258 G/A cg19274914 chr2:15703543 NA 0.38 5.8 0.3 1.53e-8 Educational attainment (years of education); CRC cis rs67478160 0.571 rs1155751 chr14:104286547 C/G cg08213375 chr14:104286397 PPP1R13B 0.66 13.82 0.61 1.49e-34 Schizophrenia; CRC cis rs8078723 0.966 rs2227322 chr17:38171668 C/G cg17344932 chr17:38183730 MED24;SNORD124 -0.46 -7.11 -0.36 7.37e-12 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); CRC cis rs28386778 0.724 rs35092235 chr17:61944621 T/C cg06601766 chr17:61851465 DDX42;CCDC47 0.44 5.92 0.31 8.24e-9 Prudent dietary pattern; CRC cis rs28386778 0.897 rs2665844 chr17:61874455 A/G cg07362569 chr17:61921086 SMARCD2 0.37 5.7 0.3 2.64e-8 Prudent dietary pattern; CRC cis rs4862750 0.872 rs10027252 chr4:187873462 T/G cg03452623 chr4:187889614 NA -0.89 -18.87 -0.72 2.38e-54 Lobe attachment (rater-scored or self-reported); CRC cis rs2050392 0.624 rs2489842 chr10:30721991 T/C cg18806716 chr10:30721971 MAP3K8 -0.71 -10.23 -0.49 1.62e-21 Inflammatory bowel disease; CRC cis rs1728785 1.000 rs6499181 chr16:68593002 A/T cg02972257 chr16:68554789 NA -0.6 -7.54 -0.38 4.71e-13 Ulcerative colitis; CRC cis rs12142240 0.698 rs57267378 chr1:46816644 A/G cg00530320 chr1:46809349 NSUN4 0.57 7.75 0.39 1.19e-13 Menopause (age at onset); CRC cis rs77956314 0.515 rs10850741 chr12:117432004 A/G cg02017074 chr12:117425053 FBXW8 0.65 8.31 0.42 2.61e-15 Subcortical brain region volumes;Hippocampal volume; CRC cis rs904251 0.802 rs2646933 chr6:37402070 C/G cg25019722 chr6:37503610 NA -0.4 -6.72 -0.35 8.2e-11 Cognitive performance; CRC cis rs875971 0.545 rs1547529 chr7:65723846 T/C cg11764359 chr7:65958608 NA 0.47 5.98 0.31 5.7e-9 Aortic root size; CRC cis rs9346649 0.630 rs4708643 chr6:168491681 A/G cg02770688 chr6:168491649 NA 0.63 9.15 0.45 6.24e-18 Venous thromboembolism adjusted for sickle cell variant rs77121243-T; CRC cis rs769267 0.965 rs1469712 chr19:19528821 C/A cg01262667 chr19:19385393 TM6SF2 0.38 6.39 0.33 5.6e-10 Tonsillectomy; CRC cis rs13108904 0.901 rs2293634 chr4:1291711 T/G cg19318889 chr4:1322082 MAEA 0.45 6.71 0.35 8.68e-11 Obesity-related traits; CRC cis rs73206853 0.563 rs1050587 chr12:111158161 T/C cg12870014 chr12:110450643 ANKRD13A 0.78 9.52 0.46 3.96e-19 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC cis rs755249 0.567 rs41270803 chr1:39766041 A/G cg18385671 chr1:39797026 MACF1 -0.42 -5.98 -0.31 5.94e-9 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs644799 0.965 rs11021317 chr11:95517576 C/T cg25622487 chr11:95524042 FAM76B;CEP57 0.76 11.68 0.54 1.28e-26 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs6684428 0.536 rs4468206 chr1:56397362 A/T cg19679543 chr1:56394286 NA 0.35 5.79 0.3 1.64e-8 Airflow obstruction; CRC cis rs9768139 0.708 rs921615 chr7:158117935 A/G cg25566285 chr7:158114605 PTPRN2 0.47 7.5 0.38 6.01e-13 Calcium levels; CRC cis rs10791323 0.604 rs2853115 chr11:133707908 C/T cg00579200 chr11:133705235 NA 0.39 5.7 0.3 2.62e-8 Childhood ear infection; CRC trans rs7395662 0.658 rs8189235 chr11:48740064 G/A cg21153622 chr11:89784906 NA 0.44 7.12 0.37 6.64e-12 HDL cholesterol; CRC cis rs2295359 0.892 rs56920441 chr1:67652012 A/G cg03340356 chr1:67600835 NA 0.27 6.13 0.32 2.52e-9 Psoriasis; CRC trans rs12200782 0.649 rs9467745 chr6:26386762 G/A cg25800765 chr12:85673347 ALX1 0.26 5.96 0.31 6.54e-9 Small cell lung carcinoma; CRC cis rs548181 0.611 rs2849225 chr11:125415936 A/G cg03464685 chr11:125439445 EI24 1.38 14.37 0.62 1.1e-36 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs362296 0.511 rs2051558 chr4:3324886 G/A cg16416165 chr4:3325029 RGS12 0.44 7.39 0.38 1.25e-12 Parental longevity (mother's age at death); CRC cis rs1552244 0.882 rs13099507 chr3:10031603 G/A cg16606324 chr3:10149918 C3orf24 0.59 7.13 0.37 6.53e-12 Alzheimer's disease; CRC cis rs835154 0.900 rs835153 chr5:14877474 A/G cg18064842 chr5:14874549 NA -0.47 -7.2 -0.37 4.14e-12 Blood metabolite levels; CRC cis rs7737355 1.000 rs798415 chr5:130693723 T/G cg06307176 chr5:131281290 NA -0.39 -5.6 -0.3 4.46e-8 Life satisfaction; CRC cis rs9942416 0.660 rs4704231 chr5:74986576 G/A cg00601450 chr5:74908170 NA 0.41 5.76 0.3 1.95e-8 Age-related disease endophenotypes; CRC cis rs243505 0.595 rs10233740 chr7:148567263 C/T cg09806900 chr7:148480153 CUL1 0.49 6.14 0.32 2.34e-9 Inflammatory bowel disease;Crohn's disease; CRC cis rs73198271 0.530 rs113160067 chr8:8654521 A/C cg01851573 chr8:8652454 MFHAS1 0.55 6.92 0.36 2.4e-11 Bone ultrasound measurement (broadband ultrasound attenuation); CRC cis rs4731207 0.596 rs1585967 chr7:124613344 T/C cg23710748 chr7:124431027 NA -0.39 -6.25 -0.33 1.29e-9 Cutaneous malignant melanoma; CRC trans rs9291683 0.561 rs3733584 chr4:10036506 T/C cg26043149 chr18:55253948 FECH 0.53 8.17 0.41 6.8e-15 Bone mineral density; CRC cis rs3026101 0.671 rs3026129 chr17:5295371 T/C cg25236894 chr17:5323110 RPAIN;NUP88 0.42 6.84 0.35 3.98e-11 Body mass index; CRC cis rs16852403 0.658 rs10157702 chr1:178109045 G/A cg00404053 chr1:178313656 RASAL2 0.61 7.68 0.39 1.89e-13 Childhood ear infection; CRC cis rs66679842 1 rs66679842 chr6:88171407 AC/A cg08069147 chr6:88032118 GJB7;C6orf162 -0.43 -5.62 -0.3 4.14e-8 Itch intensity from mosquito bite adjusted by bite size; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg14479329 chr6:167370587 RNASET2 -0.43 -6.23 -0.32 1.45e-9 Myopia (pathological); CRC trans rs4689592 0.554 rs3822270 chr4:7069804 C/A cg07817883 chr1:32538562 TMEM39B -0.61 -7.69 -0.39 1.75e-13 Monocyte percentage of white cells; CRC cis rs9381040 0.655 rs9381029 chr6:41026453 G/C cg25110423 chr6:41068646 NFYA;LOC221442 -0.38 -5.81 -0.3 1.49e-8 Alzheimer's disease (late onset); CRC cis rs501120 0.535 rs10900002 chr10:44697564 A/T cg09554077 chr10:44749378 NA 0.69 7.91 0.4 4.04e-14 Coronary artery disease;Coronary heart disease; CRC cis rs72730918 0.618 rs1531157 chr15:51990058 A/T cg14296394 chr15:51910925 DMXL2 0.46 5.84 0.31 1.25e-8 Intelligence (multi-trait analysis); CRC cis rs1165668 0.785 rs2583223 chr12:104316841 G/A cg21863207 chr12:104234989 NT5DC3 0.49 7.36 0.38 1.52e-12 Coronary heart disease (SNP X SNP interaction); CRC cis rs853679 0.567 rs7754960 chr6:28346945 G/C cg21251018 chr6:28226885 NKAPL 0.42 6.05 0.32 3.95e-9 Depression; CRC cis rs7833986 0.941 rs13278255 chr8:57067975 C/T cg23139584 chr8:56987506 RPS20;SNORD54 0.62 7.94 0.4 3.19e-14 Height; CRC cis rs1218582 0.772 rs6683557 chr1:154852307 C/G cg24250549 chr1:154909240 PMVK 0.64 10.94 0.52 5.69e-24 Prostate cancer; CRC cis rs6867032 0.917 rs10474733 chr5:2004160 A/G cg26168224 chr5:2018326 NA -0.85 -13.74 -0.6 2.97e-34 Gut microbiome composition (winter); CRC trans rs7395662 0.597 rs2135684 chr11:48748469 G/A cg21153622 chr11:89784906 NA -0.47 -7.63 -0.39 2.61e-13 HDL cholesterol; CRC cis rs4713675 0.505 rs2395450 chr6:33654588 C/T cg14003231 chr6:33640908 ITPR3 0.51 8.04 0.41 1.64e-14 Plateletcrit; CRC cis rs9906944 0.707 rs9916472 chr17:47109998 C/T cg09029085 chr17:47094198 IGF2BP1 0.3 5.61 0.3 4.37e-8 Intelligence (multi-trait analysis);Body fat percentage; CRC trans rs1656966 1.000 rs1656966 chr3:186466252 C/T cg21292957 chr21:34602922 IFNAR2 0.41 6.32 0.33 8.35e-10 Myopia (pathological); CRC cis rs10540 0.730 rs61877766 chr11:512973 T/G cg21784768 chr11:537496 LRRC56 -0.7 -6.6 -0.34 1.65e-10 Body mass index; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg09525523 chr12:16064153 DERA 0.39 6.22 0.32 1.52e-9 Liver disease severity in Alagille syndrome; CRC cis rs3820068 0.626 rs61103742 chr1:15909153 A/C cg27534772 chr1:16042836 PLEKHM2 0.51 9.18 0.45 5.06e-18 Systolic blood pressure; CRC cis rs116095464 0.542 rs28650039 chr5:273954 C/A cg22857025 chr5:266934 NA -1.25 -16.7 -0.68 9.21e-46 Breast cancer; CRC cis rs1552244 0.554 rs6800204 chr3:9995404 A/G cg18598329 chr3:10140678 FANCD2;C3orf24 -0.52 -7.53 -0.38 4.79e-13 Alzheimer's disease; CRC cis rs7940866 0.845 rs1991899 chr11:130801649 C/T cg12179176 chr11:130786555 SNX19 -0.55 -8.4 -0.42 1.39e-15 Schizophrenia; CRC cis rs7692995 1.000 rs7663818 chr4:17936443 C/T cg08925142 chr4:18023851 LCORL -0.53 -5.83 -0.31 1.34e-8 Height; CRC cis rs4665809 0.590 rs1122972 chr2:26418788 A/C cg04944784 chr2:26401820 FAM59B -0.82 -10.57 -0.5 1.14e-22 Gut microbiome composition (summer); CRC cis rs7786808 0.741 rs62479982 chr7:158227546 A/G cg17401720 chr7:158221031 PTPRN2 0.49 8.14 0.41 8.16e-15 Obesity-related traits; CRC cis rs10504229 0.953 rs67886764 chr8:58187117 T/C cg05313129 chr8:58192883 C8orf71 -0.47 -6.99 -0.36 1.49e-11 Developmental language disorder (linguistic errors); CRC cis rs7246657 0.943 rs7255952 chr19:37988797 A/G cg23950597 chr19:37808831 NA -0.52 -6.18 -0.32 1.87e-9 Coronary artery calcification; CRC cis rs367615 0.552 rs2416210 chr5:108741137 C/T cg17395555 chr5:108820864 NA -0.34 -6.69 -0.35 9.8e-11 Colorectal cancer (SNP x SNP interaction); CRC cis rs6142102 0.961 rs973409 chr20:32536364 A/G cg08999081 chr20:33150536 PIGU 0.4 5.76 0.3 1.97e-8 Skin pigmentation; CRC cis rs6088813 1.000 rs62211529 chr20:33959315 T/C cg14752227 chr20:34000481 UQCC -0.37 -5.6 -0.3 4.46e-8 Height; CRC cis rs3733346 0.553 rs6813110 chr4:942660 C/T cg20456258 chr4:962124 DGKQ 0.3 6.52 0.34 2.58e-10 Sjögren's syndrome; CRC cis rs7666738 0.830 rs13148913 chr4:99009732 C/T cg05340658 chr4:99064831 C4orf37 0.61 9.54 0.47 3.44e-19 Colonoscopy-negative controls vs population controls; CRC cis rs208520 0.837 rs208471 chr6:66916749 A/C cg07460842 chr6:66804631 NA -0.94 -12.2 -0.56 1.65e-28 Exhaled nitric oxide output; CRC cis rs10504229 0.683 rs72650839 chr8:58130029 C/T cg02725872 chr8:58115012 NA -0.64 -11.55 -0.54 3.85e-26 Developmental language disorder (linguistic errors); CRC cis rs637571 0.528 rs11602769 chr11:65594139 T/C cg26695010 chr11:65641043 EFEMP2 0.51 7.68 0.39 1.78e-13 Eosinophil percentage of white cells; CRC cis rs2075371 1.000 rs2544211 chr7:133973230 A/G cg20476274 chr7:133979776 SLC35B4 0.78 13.72 0.6 3.43e-34 Mean platelet volume; CRC cis rs10504229 1.000 rs57941207 chr8:58169821 A/G cg24829409 chr8:58192753 C8orf71 -0.67 -11.0 -0.52 3.54e-24 Developmental language disorder (linguistic errors); CRC cis rs11677370 0.603 rs11675498 chr2:3850943 G/T cg17052675 chr2:3827356 NA -0.67 -10.92 -0.52 6.77e-24 Type 2 diabetes; CRC cis rs4665809 1.000 rs4665821 chr2:26309949 A/C cg27170947 chr2:26402098 FAM59B -0.45 -6.03 -0.32 4.4e-9 Gut microbiome composition (summer); CRC cis rs2073499 1.000 rs12629572 chr3:50324672 T/G cg09545109 chr3:50388910 TUSC4;CYB561D2 0.57 6.27 0.33 1.14e-9 Schizophrenia; CRC cis rs6570726 0.791 rs365869 chr6:145884751 C/T cg13319975 chr6:146136371 FBXO30 -0.44 -6.54 -0.34 2.39e-10 Lobe attachment (rater-scored or self-reported); CRC trans rs2243480 1.000 rs35058610 chr7:65390925 G/A cg10756647 chr7:56101905 PSPH 0.73 7.99 0.4 2.25e-14 Diabetic kidney disease; CRC cis rs1005277 0.579 rs2505194 chr10:38393881 C/T cg25517755 chr10:38738941 LOC399744 -0.44 -6.32 -0.33 8.37e-10 Extrinsic epigenetic age acceleration; CRC cis rs10504229 0.679 rs12679941 chr8:58051812 G/T cg11062466 chr8:58055876 NA 0.42 5.83 0.31 1.31e-8 Developmental language disorder (linguistic errors); CRC cis rs7647973 0.593 rs9870755 chr3:49809841 A/G cg13072238 chr3:49761600 GMPPB -0.49 -5.72 -0.3 2.37e-8 Menarche (age at onset); CRC cis rs7917772 0.503 rs7087665 chr10:104282418 T/C cg11453585 chr10:104263688 ACTR1A;SUFU 0.91 17.47 0.69 8.43e-49 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC trans rs7267979 1.000 rs4815405 chr20:25317492 T/C cg17903999 chr18:56338584 MALT1 0.42 6.91 0.36 2.48e-11 Liver enzyme levels (alkaline phosphatase); CRC cis rs8141529 0.956 rs469989 chr22:29303595 G/C cg15103426 chr22:29168792 CCDC117 -0.48 -6.58 -0.34 1.85e-10 Lymphocyte counts; CRC trans rs2929451 0.566 rs17658270 chr8:9153619 C/G cg06636001 chr8:8085503 FLJ10661 0.43 6.32 0.33 8.44e-10 Nose size; CRC cis rs12477438 0.765 rs12470471 chr2:99689141 A/T cg26064155 chr2:99771622 LIPT1;TSGA10 0.6 8.14 0.41 8.11e-15 Chronic sinus infection; CRC cis rs7666738 0.830 rs11947027 chr4:99005941 T/C cg05340658 chr4:99064831 C4orf37 0.61 9.54 0.47 3.44e-19 Colonoscopy-negative controls vs population controls; CRC cis rs13256369 0.950 rs13248096 chr8:8577476 C/T cg06636001 chr8:8085503 FLJ10661 0.51 6.67 0.35 1.08e-10 Obesity-related traits; CRC cis rs875971 0.965 rs10267430 chr7:65743023 G/T cg12463550 chr7:65579703 CRCP -0.48 -6.86 -0.35 3.42e-11 Aortic root size; CRC cis rs644799 0.672 rs11021347 chr11:95653494 T/C cg03916912 chr11:95522834 CEP57;FAM76B 0.85 15.15 0.64 1.02e-39 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs6952808 0.595 rs2398705 chr7:2164995 G/A cg22963979 chr7:1858916 MAD1L1 -0.45 -6.43 -0.33 4.57e-10 Bipolar disorder and schizophrenia; CRC cis rs10743315 0.643 rs12578443 chr12:19321893 G/C cg02471346 chr12:19282374 PLEKHA5 0.72 6.82 0.35 4.32e-11 Gut microbiota (bacterial taxa); CRC cis rs4689592 0.554 rs3951346 chr4:7073321 C/T cg06697600 chr4:7070879 GRPEL1 -0.45 -6.74 -0.35 6.93e-11 Monocyte percentage of white cells; CRC cis rs2836950 0.545 rs2836959 chr21:40623668 T/G cg06238570 chr21:40685208 BRWD1 -0.63 -9.18 -0.45 4.78e-18 Menarche (age at onset); CRC cis rs13108904 0.870 rs1960426 chr4:1274365 C/T cg16405210 chr4:1374714 KIAA1530 -0.42 -6.02 -0.32 4.55e-9 Obesity-related traits; CRC cis rs9443645 0.901 rs1567167 chr6:79553827 C/T cg09184832 chr6:79620586 NA -0.5 -9.44 -0.46 7.08e-19 Intelligence (multi-trait analysis); CRC cis rs1801251 1.000 rs2592102 chr2:233726772 G/T cg25237894 chr2:233734115 C2orf82 -0.53 -8.47 -0.42 8.28e-16 Coronary artery disease; CRC cis rs2976388 0.578 rs3758081 chr8:143824373 A/G cg20041105 chr8:143859282 LYNX1 -0.44 -6.9 -0.36 2.74e-11 Urinary tract infection frequency; CRC cis rs6951245 1.000 rs74347384 chr7:1072440 G/A cg26224354 chr7:1096374 C7orf50;GPR146 -0.88 -11.08 -0.52 1.89e-24 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs1218582 0.772 rs12069356 chr1:154849771 C/T cg24250549 chr1:154909240 PMVK 0.6 10.02 0.48 8.42e-21 Prostate cancer; CRC cis rs9858542 0.953 rs1873625 chr3:49666964 C/A cg07274523 chr3:49395745 GPX1 0.47 6.07 0.32 3.48e-9 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs6570726 0.791 rs6900040 chr6:145893134 C/T cg05347473 chr6:146136440 FBXO30 0.38 5.85 0.31 1.18e-8 Lobe attachment (rater-scored or self-reported); CRC cis rs12594515 1.000 rs8038058 chr15:45990272 C/T cg22117107 chr15:45993392 NA -0.44 -9.05 -0.45 1.27e-17 Waist circumference;Weight; CRC cis rs10197940 0.789 rs2444256 chr2:152280365 C/T cg06191203 chr2:152266755 RIF1 -0.6 -9.34 -0.46 1.52e-18 Lung cancer; CRC cis rs2180341 1.000 rs6569482 chr6:127631371 C/T cg24812749 chr6:127587940 RNF146 0.95 13.71 0.6 3.81e-34 Breast cancer; CRC trans rs7267979 0.966 rs6037083 chr20:25290543 T/C cg17903999 chr18:56338584 MALT1 0.41 6.75 0.35 6.6e-11 Liver enzyme levels (alkaline phosphatase); CRC cis rs6701037 0.566 rs10753091 chr1:175134571 T/C cg17845761 chr1:175162550 KIAA0040 0.3 6.44 0.33 4.23e-10 Alcohol dependence; CRC cis rs1218582 0.741 rs883718 chr1:154846274 C/T cg09359103 chr1:154839909 KCNN3 -0.77 -14.37 -0.62 1.12e-36 Prostate cancer; CRC cis rs2737618 0.551 rs2816989 chr1:200070765 G/T cg21825944 chr1:200113062 NR5A2 0.46 6.38 0.33 6.08e-10 Uric acid levels; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg18159324 chr12:52463368 C12orf44 0.43 6.02 0.31 4.62e-9 Response to antipsychotic treatment; CRC cis rs9486719 1.000 rs11153058 chr6:97012746 C/T cg18709589 chr6:96969512 KIAA0776 -0.52 -5.85 -0.31 1.21e-8 Migraine;Coronary artery disease; CRC cis rs1904096 0.506 rs10034781 chr4:95169682 A/C cg11021082 chr4:95130006 SMARCAD1 0.49 7.36 0.38 1.51e-12 Type 2 diabetes; CRC trans rs7618501 0.602 rs2624816 chr3:50117312 T/G cg21665057 chr3:196295764 WDR53;FBXO45 -0.58 -9.35 -0.46 1.43e-18 Intelligence (multi-trait analysis); CRC cis rs916888 0.610 rs199529 chr17:44837217 A/C cg01570182 chr17:44337453 NA 1.03 11.46 0.53 8.45e-26 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs7772486 0.754 rs4896839 chr6:146019689 T/G cg23711669 chr6:146136114 FBXO30 -0.76 -12.87 -0.58 5.54e-31 Lobe attachment (rater-scored or self-reported); CRC cis rs427394 0.659 rs274717 chr5:6721067 C/T cg15145174 chr5:6755386 POLS 0.48 7.05 0.36 1.05e-11 Menopause (age at onset); CRC cis rs2573652 0.722 rs12898366 chr15:100543067 C/T cg00587665 chr15:100533223 ADAMTS17 -0.36 -6.28 -0.33 1.07e-9 Height; CRC cis rs10089 1.000 rs62373701 chr5:127416294 C/T cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.75 10.88 0.51 9.03e-24 Ileal carcinoids; CRC cis rs2228479 0.850 rs12599473 chr16:89827435 A/C cg19635926 chr16:89946313 TCF25 0.63 5.68 0.3 3.01e-8 Skin colour saturation; CRC cis rs847577 0.630 rs6969384 chr7:97732842 C/T cg24562669 chr7:97807699 LMTK2 0.78 17.5 0.69 6.1e-49 Breast cancer; CRC cis rs11785400 1.000 rs13265663 chr8:143732255 A/C cg24634471 chr8:143751801 JRK 0.53 7.58 0.39 3.48e-13 Schizophrenia; CRC cis rs9467773 1.000 rs12526680 chr6:26550954 A/G cg09904177 chr6:26538194 HMGN4 0.86 14.93 0.64 7.73e-39 Intelligence (multi-trait analysis); CRC cis rs10946940 0.632 rs9366698 chr6:27672035 C/G cg02683197 chr6:28174875 NA 0.51 6.17 0.32 1.99e-9 Systemic lupus erythematosus; CRC trans rs561341 0.941 rs550213 chr17:30317518 C/G cg20587970 chr11:113659929 NA -1.18 -17.19 -0.69 1.02e-47 Hip circumference adjusted for BMI; CRC cis rs6570726 0.764 rs9399553 chr6:145873664 A/T cg13319975 chr6:146136371 FBXO30 -0.45 -6.62 -0.34 1.46e-10 Lobe attachment (rater-scored or self-reported); CRC trans rs1814175 0.519 rs3913237 chr11:49551828 G/A cg11707556 chr5:10655725 ANKRD33B 0.48 7.74 0.39 1.26e-13 Height; CRC trans rs1455244 0.700 rs7229302 chr18:11508904 G/T cg00508563 chr19:30335539 NA 0.46 7.41 0.38 1.1e-12 Schizophrenia; CRC cis rs9926296 0.605 rs12709094 chr16:89853017 A/G cg04287289 chr16:89883240 FANCA 0.82 14.5 0.62 3.66e-37 Vitiligo; CRC cis rs6088580 0.584 rs2378203 chr20:32993846 A/T cg24642439 chr20:33292090 TP53INP2 -0.37 -6.25 -0.33 1.28e-9 Glomerular filtration rate (creatinine); CRC cis rs10256972 0.591 rs6950319 chr7:1161324 A/G cg03188948 chr7:1209495 NA 0.46 6.56 0.34 2.08e-10 Longevity;Endometriosis; CRC cis rs514406 0.505 rs447581 chr1:53177098 T/C cg24675658 chr1:53192096 ZYG11B -0.63 -9.66 -0.47 1.34e-19 Monocyte count; CRC cis rs4713118 0.869 rs6456802 chr6:27698355 A/G cg20933634 chr6:27740509 NA 0.58 8.5 0.42 6.74e-16 Parkinson's disease; CRC cis rs6500395 1.000 rs9936454 chr16:48617782 T/G cg04672837 chr16:48644449 N4BP1 0.45 6.71 0.35 8.43e-11 Response to tocilizumab in rheumatoid arthritis; CRC cis rs1046896 1.000 rs9909940 chr17:80689036 C/T cg03160526 chr17:80928410 B3GNTL1 0.49 7.26 0.37 2.73e-12 Glycated hemoglobin levels; CRC cis rs10197940 0.545 rs2444267 chr2:152308611 T/G cg06191203 chr2:152266755 RIF1 -0.45 -6.37 -0.33 6.22e-10 Lung cancer; CRC cis rs736408 0.608 rs4687657 chr3:52852538 G/T cg10802521 chr3:52805072 NEK4 -0.47 -6.33 -0.33 8.18e-10 Bipolar disorder; CRC cis rs13191362 1.000 rs67025553 chr6:163011552 C/T cg21926612 chr6:163149169 PACRG;PARK2 0.79 10.93 0.52 6.15e-24 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs11764590 0.715 rs9969125 chr7:2088460 C/T cg02421172 chr7:1938701 MAD1L1 0.45 6.03 0.32 4.38e-9 Neuroticism; CRC cis rs4423214 1.000 rs3794060 chr11:71187679 C/T cg05163923 chr11:71159392 DHCR7 0.66 9.34 0.46 1.47e-18 Vitamin D levels; CRC cis rs9457247 0.663 rs2282860 chr6:167440244 T/C cg07741184 chr6:167504864 NA 0.35 6.32 0.33 8.58e-10 Crohn's disease; CRC cis rs8180040 0.903 rs6791842 chr3:47279810 T/C cg02527881 chr3:46936655 PTH1R -0.38 -7.03 -0.36 1.22e-11 Colorectal cancer; CRC cis rs478304 0.654 rs7947604 chr11:65442059 G/C cg05805236 chr11:65401703 PCNXL3 -0.38 -5.86 -0.31 1.13e-8 Acne (severe); CRC cis rs4253772 0.591 rs9627324 chr22:46656511 A/G cg09491104 chr22:46646882 C22orf40 -0.48 -7.41 -0.38 1.1e-12 LDL cholesterol;Cholesterol, total; CRC cis rs6502050 0.723 rs11657069 chr17:80083809 C/T cg11859384 chr17:80120422 CCDC57 0.37 5.82 0.31 1.36e-8 Life satisfaction; CRC cis rs897984 0.542 rs8061047 chr16:31068960 T/C cg02466173 chr16:30829666 NA -0.61 -9.3 -0.46 1.95e-18 Dementia with Lewy bodies; CRC cis rs1707322 0.721 rs11211151 chr1:46112752 T/C cg06784218 chr1:46089804 CCDC17 0.65 12.17 0.56 2.14e-28 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs6502050 0.835 rs7502676 chr17:80093433 C/G cg09264619 chr17:80180166 NA -0.37 -6.28 -0.33 1.04e-9 Life satisfaction; CRC cis rs1707322 0.682 rs28490344 chr1:46197948 C/T cg06784218 chr1:46089804 CCDC17 0.66 12.27 0.56 9.04e-29 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs6964587 0.692 rs10271430 chr7:91710466 G/C cg17063962 chr7:91808500 NA 0.59 9.6 0.47 2.11e-19 Breast cancer; CRC cis rs12477438 0.501 rs11692336 chr2:99740606 T/C cg26064155 chr2:99771622 LIPT1;TSGA10 0.77 13.12 0.59 6.33e-32 Chronic sinus infection; CRC cis rs6088580 0.634 rs6088483 chr20:32984714 T/A cg24642439 chr20:33292090 TP53INP2 -0.37 -6.34 -0.33 7.53e-10 Glomerular filtration rate (creatinine); CRC trans rs7267979 1.000 rs2259956 chr20:25282433 A/G cg17903999 chr18:56338584 MALT1 -0.42 -6.99 -0.36 1.52e-11 Liver enzyme levels (alkaline phosphatase); CRC cis rs6582630 0.593 rs11182590 chr12:38574274 A/T cg26384229 chr12:38710491 ALG10B 0.5 7.08 0.36 8.73e-12 Drug-induced liver injury (flucloxacillin); CRC cis rs7914558 0.966 rs10883805 chr10:104708251 T/C cg15744005 chr10:104629667 AS3MT -0.35 -7.54 -0.38 4.73e-13 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs67311347 1.000 rs9332450 chr3:40458041 C/T cg24209194 chr3:40518798 ZNF619 -0.44 -6.61 -0.34 1.56e-10 Renal cell carcinoma; CRC trans rs3942852 0.868 rs6485808 chr11:48109151 A/G cg03929089 chr4:120376271 NA -0.56 -6.25 -0.33 1.27e-9 Acute lymphoblastic leukemia (childhood); CRC trans rs10982213 0.830 rs2274163 chr9:117188714 C/T cg09765074 chr10:69634185 NA -0.38 -6.26 -0.33 1.21e-9 Interleukin-6 levels; CRC cis rs727563 0.635 rs5758444 chr22:42133921 T/A cg06481639 chr22:41940642 POLR3H 0.52 6.03 0.32 4.43e-9 Crohn's disease;Inflammatory bowel disease; CRC cis rs8062405 1.000 rs61737565 chr16:28855522 G/C cg16576597 chr16:28551801 NUPR1 0.48 6.83 0.35 4.24e-11 Cognitive ability (multi-trait analysis);Cognitive ability; CRC cis rs10979 1.000 rs9390104 chr6:143890978 T/C cg25407410 chr6:143891975 LOC285740 -0.81 -13.31 -0.59 1.21e-32 Hypospadias; CRC cis rs1448094 0.511 rs1993807 chr12:86146833 A/G cg06740227 chr12:86229804 RASSF9 -0.37 -5.64 -0.3 3.71e-8 Major depressive disorder; CRC cis rs3768617 0.510 rs1413389 chr1:183096668 C/T ch.1.3577855R chr1:183094577 LAMC1 0.89 15.86 0.66 1.84e-42 Fuchs's corneal dystrophy; CRC cis rs6952808 0.792 rs4721184 chr7:1950784 T/C cg22963979 chr7:1858916 MAD1L1 -0.52 -7.73 -0.39 1.34e-13 Bipolar disorder and schizophrenia; CRC cis rs10256972 0.706 rs4285396 chr7:1123738 A/G cg18765753 chr7:1198926 ZFAND2A -0.36 -6.13 -0.32 2.57e-9 Longevity;Endometriosis; CRC cis rs6121246 0.909 rs6087778 chr20:30354142 G/A cg13852791 chr20:30311386 BCL2L1 0.69 10.77 0.51 2.2e-23 Mean corpuscular hemoglobin; CRC trans rs2665103 0.655 rs1501367 chr15:82522816 A/G cg04831495 chr15:85060580 GOLGA6L5 -0.38 -6.14 -0.32 2.35e-9 Intelligence (multi-trait analysis); CRC cis rs477895 1.000 rs1047206 chr11:64089216 C/G cg19465662 chr11:63993652 NUDT22;TRPT1 0.65 6.25 0.33 1.25e-9 Mean platelet volume; CRC cis rs11252926 0.550 rs11252134 chr10:442599 G/A cg03684893 chr10:554711 DIP2C -0.33 -5.65 -0.3 3.42e-8 Psychosis in Alzheimer's disease; CRC cis rs4132509 0.744 rs12021907 chr1:243995640 A/G cg21452805 chr1:244014465 NA -0.57 -6.51 -0.34 2.77e-10 RR interval (heart rate); CRC cis rs67478160 0.643 rs12434686 chr14:104316033 C/T cg08213375 chr14:104286397 PPP1R13B -0.64 -13.25 -0.59 2.01e-32 Schizophrenia; CRC cis rs908922 0.651 rs564107 chr1:152519295 C/T cg09873164 chr1:152488093 CRCT1 0.37 6.29 0.33 1e-9 Hair morphology; CRC cis rs11608355 0.515 rs12818537 chr12:109902150 C/T cg05360138 chr12:110035743 NA 0.77 8.7 0.43 1.65e-16 Neuroticism; CRC cis rs1878931 0.582 rs27238 chr16:3441223 G/A cg26668626 chr16:3451006 ZNF174;ZNF434 -0.57 -6.92 -0.36 2.42e-11 Body mass index (adult); CRC cis rs67311347 0.956 rs7640228 chr3:40516190 G/A cg09455208 chr3:40491958 NA -0.46 -9.34 -0.46 1.47e-18 Renal cell carcinoma; CRC cis rs7945705 0.875 rs2653616 chr11:8885892 A/G cg21881798 chr11:8931708 C11orf17;ST5 -0.75 -12.73 -0.57 1.93e-30 Hemoglobin concentration; CRC cis rs713587 0.776 rs2118826 chr2:25191745 A/T cg04586622 chr2:25135609 ADCY3 0.35 5.74 0.3 2.1e-8 Body mass index in non-asthmatics; CRC cis rs2976388 1.000 rs2920295 chr8:143764937 A/G cg24046110 chr8:143859143 LYNX1 -0.39 -6.77 -0.35 6.02e-11 Urinary tract infection frequency; CRC trans rs17126268 0.502 rs1538826 chr1:102883645 C/T cg18468354 chr14:36993517 NA 0.38 6.12 0.32 2.65e-9 Glomerular filtration rate; CRC cis rs3750965 0.919 rs12280942 chr11:68859683 A/G cg06818126 chr11:68850279 TPCN2 0.56 8.04 0.41 1.58e-14 Hair color; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg23426587 chr9:21335126 KLHL9 0.49 6.38 0.33 6.05e-10 Thyroid stimulating hormone; CRC trans rs10875746 0.859 rs4760622 chr12:48591960 C/A cg16281234 chr15:35388805 NA -0.5 -6.37 -0.33 6.39e-10 Longevity (90 years and older); CRC cis rs7618915 0.570 rs4687633 chr3:52630548 G/A cg10802521 chr3:52805072 NEK4 -0.59 -9.08 -0.45 1.05e-17 Bipolar disorder; CRC cis rs7258465 1.000 rs8111708 chr19:18558876 A/G cg06462663 chr19:18546047 ISYNA1 0.44 6.42 0.33 4.66e-10 Breast cancer; CRC cis rs9462027 0.628 rs7741437 chr6:34737553 C/T cg07306190 chr6:34760872 UHRF1BP1 -0.35 -6.24 -0.33 1.36e-9 Systemic lupus erythematosus; CRC cis rs6860806 0.661 rs4705927 chr5:131578608 C/G cg12564285 chr5:131593104 PDLIM4 0.48 9.37 0.46 1.18e-18 Breast cancer; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg16695835 chr1:90460886 LOC492303;ZNF326 0.45 6.19 0.32 1.82e-9 Anxiety disorder; CRC cis rs1707322 1.000 rs12133129 chr1:46373348 C/T cg06784218 chr1:46089804 CCDC17 0.52 9.12 0.45 7.88e-18 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC trans rs9858542 0.951 rs1800668 chr3:49395757 G/A cg21582582 chr3:182698605 DCUN1D1 -0.52 -6.66 -0.34 1.12e-10 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs9311676 0.632 rs11925533 chr3:58429908 G/A cg06643156 chr3:58380774 PXK 0.42 6.51 0.34 2.86e-10 Systemic lupus erythematosus; CRC trans rs8035957 1.000 rs4924273 chr15:38846738 C/G cg05792022 chr13:41239732 FOXO1 -0.54 -6.4 -0.33 5.2400000000000005e-10 Type 1 diabetes; CRC cis rs875971 0.545 rs6961853 chr7:66002022 G/A cg05627663 chr7:65219948 SNORA22;CCT6P1 0.56 7.23 0.37 3.32e-12 Aortic root size; CRC cis rs798554 1.000 rs798550 chr7:2760609 A/G cg19346786 chr7:2764209 NA -0.41 -7.59 -0.39 3.4e-13 Height; CRC trans rs11098499 0.754 rs12509621 chr4:120249660 T/C cg25214090 chr10:38739885 LOC399744 0.53 8.36 0.42 1.81e-15 Corneal astigmatism; CRC cis rs2075671 0.903 rs11983334 chr7:100302434 C/T cg16850897 chr7:100343110 ZAN -0.61 -9.14 -0.45 6.37e-18 Other erythrocyte phenotypes; CRC trans rs11098499 0.954 rs28685688 chr4:120420334 T/C cg25214090 chr10:38739885 LOC399744 0.65 10.15 0.49 3.02e-21 Corneal astigmatism; CRC cis rs847577 0.715 rs4729402 chr7:97707731 A/G cg24562669 chr7:97807699 LMTK2 0.63 11.39 0.53 1.43e-25 Breast cancer; CRC cis rs13256369 1.000 rs10088439 chr8:8576699 T/G cg18904891 chr8:8559673 CLDN23 0.52 6.94 0.36 2.09e-11 Obesity-related traits; CRC cis rs72945132 0.882 rs12279046 chr11:70130388 A/G cg00319359 chr11:70116639 PPFIA1 0.61 6.79 0.35 5.14e-11 Coronary artery disease; CRC trans rs1455244 0.700 rs7229302 chr18:11508904 G/T cg04594242 chr17:7737283 NA 0.38 5.96 0.31 6.55e-9 Schizophrenia; CRC cis rs10886503 0.623 rs10787973 chr10:121257200 A/G cg17804342 chr10:121271663 RGS10 -0.49 -5.98 -0.31 5.76e-9 Obstetric antiphospholipid syndrome; CRC cis rs9818758 0.607 rs10049462 chr3:49309684 C/T cg00383909 chr3:49044727 WDR6 1.1 10.48 0.5 2.33e-22 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; CRC cis rs3087591 0.919 rs2952993 chr17:29539998 G/A cg24425628 chr17:29625626 OMG;NF1 0.82 14.5 0.62 3.4e-37 Hip circumference; CRC cis rs7772486 0.686 rs9399565 chr6:146081906 G/T cg23711669 chr6:146136114 FBXO30 -0.66 -11.09 -0.52 1.77e-24 Lobe attachment (rater-scored or self-reported); CRC cis rs995000 0.931 rs10889354 chr1:63129082 T/C cg19896129 chr1:63156450 NA 0.39 5.83 0.31 1.36e-8 Triglyceride levels; CRC cis rs561341 1.000 rs498391 chr17:30328704 G/A cg19193384 chr17:30244184 NA -0.65 -7.56 -0.38 4.14e-13 Hip circumference adjusted for BMI; CRC cis rs4523957 0.855 rs9896535 chr17:2133205 C/T cg16513277 chr17:2031491 SMG6 -0.52 -8.79 -0.44 8.39e-17 Autism spectrum disorder or schizophrenia;Schizophrenia; CRC cis rs11148252 0.553 rs2147692 chr13:53287023 C/G cg02158880 chr13:53174818 NA 0.57 9.33 0.46 1.6e-18 Lewy body disease; CRC cis rs6952808 1.000 rs4721122 chr7:1893311 C/G cg20295408 chr7:1910781 MAD1L1 -0.39 -5.62 -0.3 4.01e-8 Bipolar disorder and schizophrenia; CRC trans rs2727020 0.634 rs11040331 chr11:49345726 T/C cg11707556 chr5:10655725 ANKRD33B -0.42 -6.48 -0.34 3.27e-10 Coronary artery disease; CRC cis rs6764363 0.504 rs4684334 chr3:278697 A/C cg02057681 chr3:285234 CHL1 0.41 7.0 0.36 1.44e-11 Sudden cardiac arrest; CRC trans rs11098499 0.913 rs35271032 chr4:120156659 C/T cg25214090 chr10:38739885 LOC399744 0.5 7.73 0.39 1.29e-13 Corneal astigmatism; CRC cis rs7726839 1.000 rs7726839 chr5:618586 A/G cg16447950 chr5:562315 NA -0.57 -9.14 -0.45 6.49e-18 Obesity-related traits; CRC cis rs400736 0.930 rs370812 chr1:8075894 C/T cg25007680 chr1:8021821 PARK7 0.54 7.67 0.39 2e-13 Response to antidepressants and depression; CRC cis rs4727027 0.870 rs13237714 chr7:148884083 A/G cg12479418 chr7:148823350 ZNF425;ZNF398 0.46 6.27 0.33 1.12e-9 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC trans rs7618501 0.633 rs2252833 chr3:50004209 C/T cg21659725 chr3:3221576 CRBN 0.53 8.17 0.41 6.59e-15 Intelligence (multi-trait analysis); CRC cis rs10463316 0.894 rs6880137 chr5:150755232 A/G cg03212797 chr5:150827313 SLC36A1 -0.5 -7.93 -0.4 3.57e-14 Metabolite levels (Pyroglutamine); CRC trans rs10983614 1.000 rs7867776 chr9:120072627 A/G cg10180764 chr2:128284465 IWS1 0.45 6.08 0.32 3.25e-9 Survival in pancreatic cancer; CRC cis rs11098499 0.954 rs7687843 chr4:120421211 C/T cg24375607 chr4:120327624 NA 0.48 7.34 0.38 1.69e-12 Corneal astigmatism; CRC cis rs9467711 0.606 rs34878490 chr6:26370572 C/T cg16898833 chr6:26189333 HIST1H4D 0.76 6.58 0.34 1.88e-10 Autism spectrum disorder or schizophrenia; CRC cis rs3768617 0.811 rs12066082 chr1:183054863 G/C ch.1.3577855R chr1:183094577 LAMC1 0.61 9.0 0.44 1.81e-17 Fuchs's corneal dystrophy; CRC cis rs11212617 0.837 rs10890822 chr11:108027060 C/A cg01991180 chr11:108092276 ATM;NPAT 0.43 6.34 0.33 7.45e-10 Response to metformin in type 2 diabetes (glycemic); CRC cis rs372883 0.648 rs382732 chr21:30719010 A/G cg24692254 chr21:30365293 RNF160 0.58 8.8 0.44 8.1e-17 Pancreatic cancer; CRC cis rs6743376 0.556 rs2515391 chr2:113815997 C/T cg24553058 chr2:113831203 IL1F10 0.39 6.44 0.33 4.13e-10 Inflammatory biomarkers; CRC cis rs7811142 0.830 rs11771936 chr7:99943283 A/G cg00814883 chr7:100076585 TSC22D4 -0.71 -8.75 -0.43 1.13e-16 Platelet count; CRC cis rs9463078 0.683 rs227841 chr6:44690309 A/T cg25276700 chr6:44698697 NA 0.25 5.93 0.31 7.62e-9 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; CRC cis rs9942416 0.660 rs194137 chr5:74978857 G/A cg19683494 chr5:74908142 NA -0.49 -6.26 -0.33 1.23e-9 Age-related disease endophenotypes; CRC cis rs6598955 0.670 rs3795688 chr1:26560481 C/A cg00852783 chr1:26633632 UBXN11 0.43 6.96 0.36 1.89e-11 Obesity-related traits; CRC trans rs7613875 0.620 rs7430334 chr3:50078221 T/C cg21659725 chr3:3221576 CRBN -0.46 -6.84 -0.35 3.92e-11 Body mass index; CRC cis rs9314323 0.592 rs12165 chr8:26269412 C/T cg13160058 chr8:26243215 BNIP3L -0.39 -6.87 -0.35 3.28e-11 Red cell distribution width; CRC trans rs916888 0.773 rs199451 chr17:44801784 G/A cg07870213 chr5:140052090 DND1 1.01 11.43 0.53 1.09e-25 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs6952808 0.609 rs10230383 chr7:1950113 T/C cg14004847 chr7:1930337 MAD1L1 -0.41 -6.0 -0.31 5.12e-9 Bipolar disorder and schizophrenia; CRC cis rs6951245 0.554 rs11544331 chr7:1131411 C/T cg26224354 chr7:1096374 C7orf50;GPR146 -0.63 -8.51 -0.42 6.31e-16 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs863345 0.604 rs12059669 chr1:158501480 T/C cg12129480 chr1:158549410 OR10X1 -0.3 -6.27 -0.33 1.12e-9 Pneumococcal bacteremia; CRC cis rs4731207 0.698 rs7778956 chr7:124527733 C/T cg23710748 chr7:124431027 NA -0.37 -5.99 -0.31 5.5e-9 Cutaneous malignant melanoma; CRC cis rs853679 1.000 rs853694 chr6:28279100 A/T cg03623178 chr6:28175578 NA 0.68 7.02 0.36 1.24e-11 Depression; CRC cis rs2380220 0.576 rs4368819 chr6:96031109 T/G cg23517279 chr6:96025343 MANEA 0.55 6.39 0.33 5.62e-10 Behavioural disinhibition (generation interaction); CRC cis rs10504229 1.000 rs111915672 chr8:58191665 T/C cg22535103 chr8:58192502 C8orf71 -0.81 -11.95 -0.55 1.34e-27 Developmental language disorder (linguistic errors); CRC cis rs6502050 0.805 rs8082653 chr17:80162382 G/A cg22110888 chr17:80059540 CCDC57 0.41 6.57 0.34 2.01e-10 Life satisfaction; CRC cis rs2760061 0.819 rs708115 chr1:228198046 C/T cg18477163 chr1:228402036 OBSCN 0.44 7.4 0.38 1.12e-12 Diastolic blood pressure; CRC cis rs9311474 0.508 rs1570 chr3:52586682 T/A cg18404041 chr3:52824283 ITIH1 -0.41 -8.71 -0.43 1.56e-16 Electroencephalogram traits; CRC cis rs6977660 0.652 rs12673842 chr7:19747437 T/C cg07541023 chr7:19748670 TWISTNB 1.14 10.61 0.5 8.13e-23 Thyroid stimulating hormone; CRC cis rs55702914 0.837 rs2195507 chr2:198172336 T/C cg10820045 chr2:198174542 NA -0.46 -8.61 -0.43 3.05e-16 Major depression and alcohol dependence; CRC cis rs3768617 0.510 rs12086466 chr1:183075778 C/T ch.1.3577855R chr1:183094577 LAMC1 -0.88 -16.31 -0.67 2.94e-44 Fuchs's corneal dystrophy; CRC cis rs344364 0.511 rs2982452 chr16:1949511 G/A cg09830162 chr16:1889614 FAHD1;C16orf73 -0.77 -9.36 -0.46 1.32e-18 Glomerular filtration rate in chronic kidney disease; CRC cis rs7044106 0.762 rs10984972 chr9:123409864 T/C cg09419670 chr9:123605666 PSMD5;LOC253039 0.7 11.43 0.53 1.04e-25 Hip circumference adjusted for BMI; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg08402873 chr20:10653164 JAG1 0.49 6.24 0.33 1.35e-9 Thyroid stimulating hormone; CRC cis rs727505 0.607 rs67313231 chr7:124804532 T/A cg23710748 chr7:124431027 NA -0.61 -10.22 -0.49 1.82e-21 Lewy body disease; CRC cis rs887829 0.570 rs6759892 chr2:234601669 G/T cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 0.45 7.04 0.36 1.13e-11 Metabolic traits;Bilirubin levels;Cholelithiasis-related traits in sickle cell anemia;Metabolite levels;Total bilirubin levels in HIV-1 infection;Serum metabolite levels;Blood metabolite levels; CRC cis rs13256369 1.000 rs13267501 chr8:8574058 G/A cg00074818 chr8:8560427 CLDN23 0.36 6.71 0.35 8.62e-11 Obesity-related traits; CRC trans rs8124695 0.764 rs6029084 chr20:39007766 C/T cg15699267 chr20:61809557 MIR124-3 -0.53 -6.04 -0.32 4.19e-9 Dupuytren's disease; CRC cis rs1348850 0.914 rs6761593 chr2:178451600 A/G cg22681709 chr2:178499509 PDE11A 0.33 6.15 0.32 2.2e-9 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs5745709 0.861 rs4732404 chr7:81363897 G/T cg18944653 chr7:81381353 HGF 0.3 5.66 0.3 3.32e-8 Gout; CRC cis rs7918232 0.941 rs7096505 chr10:27326999 T/C cg14240646 chr10:27532245 ACBD5 -0.82 -9.12 -0.45 7.54e-18 Breast cancer; CRC cis rs11123170 0.529 rs35606997 chr2:113973350 G/A cg21482265 chr2:113992762 PAX8;LOC440839;LOC654433 0.47 5.79 0.3 1.61e-8 Renal function-related traits (BUN); CRC cis rs13118159 0.742 rs34947293 chr4:1335034 T/C cg23123621 chr4:1343375 KIAA1530 0.38 6.89 0.35 2.9e-11 Longevity; CRC cis rs3749237 1.000 rs4768 chr3:49758764 A/G cg03060546 chr3:49711283 APEH 0.51 7.62 0.39 2.77e-13 Resting heart rate; CRC cis rs651907 0.535 rs12631513 chr3:101517476 A/C cg12386194 chr3:101231763 SENP7 0.52 7.45 0.38 8.46e-13 Colorectal cancer; CRC cis rs2243480 1.000 rs160634 chr7:65528664 C/T cg25985355 chr7:65971099 NA 0.46 6.2 0.32 1.68e-9 Diabetic kidney disease; CRC cis rs2033711 0.870 rs7408188 chr19:58939389 T/G cg13877915 chr19:58951672 ZNF132 0.52 8.66 0.43 2.11e-16 Uric acid clearance; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg24794758 chr19:54663461 LENG1 0.41 6.09 0.32 3.22e-9 Intelligence (multi-trait analysis); CRC cis rs5758511 0.773 rs7288749 chr22:42356430 C/T cg00645731 chr22:42541494 CYP2D7P1 0.49 7.36 0.38 1.52e-12 Birth weight; CRC cis rs7705042 0.865 rs4912622 chr5:141490587 A/G cg08523384 chr5:141488047 NDFIP1 0.33 5.84 0.31 1.25e-8 Asthma; CRC cis rs11758351 0.660 rs56398712 chr6:26213868 A/G cg08260959 chr6:26240920 HIST1H4F -0.35 -5.6 -0.3 4.46e-8 Gout;Renal underexcretion gout; CRC cis rs2179367 0.887 rs2789488 chr6:149725290 A/G cg07828024 chr6:149772892 ZC3H12D 0.34 5.85 0.31 1.19e-8 Dupuytren's disease; CRC cis rs7799006 0.527 rs3779009 chr7:2203692 G/C cg04267008 chr7:1944627 MAD1L1 -0.45 -5.78 -0.3 1.75e-8 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs4713118 0.539 rs510987 chr6:27847517 G/A cg26587870 chr6:27730563 NA -0.44 -6.65 -0.34 1.2e-10 Parkinson's disease; CRC cis rs10504229 0.636 rs77753517 chr8:58115897 C/T cg24829409 chr8:58192753 C8orf71 -0.55 -8.03 -0.4 1.71e-14 Developmental language disorder (linguistic errors); CRC cis rs2415984 0.579 rs2255935 chr14:46964271 A/G cg14871534 chr14:47121158 RPL10L 0.4 5.96 0.31 6.64e-9 Number of children ever born; CRC cis rs3733585 0.563 rs881971 chr4:9930962 A/G cg11266682 chr4:10021025 SLC2A9 -0.48 -9.62 -0.47 1.84e-19 Cleft plate (environmental tobacco smoke interaction); CRC cis rs8072100 0.935 rs12943464 chr17:45690351 A/T cg08085267 chr17:45401833 C17orf57 0.61 9.66 0.47 1.36e-19 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs10888329 0.745 rs10888324 chr1:248361268 G/A cg00666640 chr1:248458726 OR2T12 0.44 7.07 0.36 9.39e-12 Autism spectrum disorder; CRC cis rs8180040 1.000 rs553989 chr3:47400328 A/G cg02527881 chr3:46936655 PTH1R 0.38 7.09 0.36 8.08e-12 Colorectal cancer; CRC cis rs7772486 0.720 rs702320 chr6:146006654 G/A cg23711669 chr6:146136114 FBXO30 -0.76 -12.99 -0.58 1.96e-31 Lobe attachment (rater-scored or self-reported); CRC cis rs9291683 0.510 rs4318649 chr4:10016815 T/C cg11266682 chr4:10021025 SLC2A9 0.54 11.08 0.52 1.79e-24 Bone mineral density; CRC cis rs6840360 0.615 rs12641433 chr4:152607548 A/C cg09659197 chr4:152720779 NA 0.39 7.56 0.38 4.18e-13 Intelligence (multi-trait analysis); CRC cis rs2302777 0.507 rs9889711 chr17:38108292 A/T cg24910161 chr17:38119198 GSDMA -0.36 -5.94 -0.31 7.28e-9 Multiple myeloma (hyperdiploidy); CRC cis rs6952808 0.595 rs3800917 chr7:2167939 A/G cg04267008 chr7:1944627 MAD1L1 0.67 9.25 0.45 2.89e-18 Bipolar disorder and schizophrenia; CRC cis rs1448094 0.512 rs4540904 chr12:86235472 A/G cg18827107 chr12:86230957 RASSF9 -0.46 -7.69 -0.39 1.68e-13 Major depressive disorder; CRC cis rs7772486 0.558 rs7753273 chr6:146066039 C/T cg05347473 chr6:146136440 FBXO30 -0.5 -7.18 -0.37 4.54e-12 Lobe attachment (rater-scored or self-reported); CRC cis rs2949837 0.581 rs1542819 chr7:45978059 T/C cg04796162 chr7:45961102 IGFBP3 0.4 6.83 0.35 4.07e-11 Sitting height ratio; CRC cis rs875971 0.862 rs3926380 chr7:66080645 G/T cg12463550 chr7:65579703 CRCP -0.47 -6.3 -0.33 9.38e-10 Aortic root size; CRC cis rs9902453 0.934 rs4343336 chr17:28488236 A/C cg26525008 chr17:28256777 EFCAB5;SSH2 0.58 9.14 0.45 6.58e-18 Coffee consumption (cups per day); CRC cis rs9291683 0.530 rs17246501 chr4:9985710 A/C cg11266682 chr4:10021025 SLC2A9 0.51 10.49 0.5 2.11e-22 Bone mineral density; CRC cis rs6088580 0.567 rs6088520 chr20:33132364 A/G cg24642439 chr20:33292090 TP53INP2 -0.36 -5.92 -0.31 7.92e-9 Glomerular filtration rate (creatinine); CRC cis rs8177253 0.965 rs4854761 chr3:133498789 A/G cg11941060 chr3:133502564 NA 0.56 9.64 0.47 1.54e-19 Iron status biomarkers; CRC cis rs11148252 0.840 rs4369550 chr13:52744910 A/G cg02158880 chr13:53174818 NA 0.44 6.59 0.34 1.79e-10 Lewy body disease; CRC cis rs10242455 0.557 rs2404487 chr7:99038057 G/A cg18809830 chr7:99032528 PTCD1 -1.03 -7.68 -0.39 1.85e-13 Blood metabolite levels; CRC cis rs2777491 0.540 rs7164684 chr15:41705008 G/T cg18705301 chr15:41695430 NDUFAF1 -1.11 -18.75 -0.72 7.06e-54 Ulcerative colitis; CRC cis rs4555082 0.834 rs2735817 chr14:105717796 A/G cg13114125 chr14:105738426 BRF1 0.8 12.18 0.56 1.95e-28 Mean platelet volume;Platelet distribution width; CRC cis rs8031584 0.958 rs11629793 chr15:31238423 G/A cg14829155 chr15:31115871 NA -0.48 -7.8 -0.4 8.13e-14 Huntington's disease progression; CRC cis rs4319547 0.695 rs12314643 chr12:122917423 C/T cg23029597 chr12:123009494 RSRC2 -0.5 -6.61 -0.34 1.55e-10 Body mass index; CRC cis rs2228479 0.717 rs11649210 chr16:89807233 C/G cg06558623 chr16:89946397 TCF25 0.89 8.86 0.44 4.97e-17 Skin colour saturation; CRC cis rs10971721 0.822 rs12376664 chr9:33808703 T/A cg13495928 chr9:33750294 PRSS3 0.56 5.85 0.31 1.16e-8 Body mass index; CRC cis rs2070488 0.574 rs57754356 chr3:38488706 C/G cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.75 13.13 0.59 5.98e-32 Electrocardiographic conduction measures; CRC cis rs731174 0.759 rs575254 chr1:38149692 C/G cg06917450 chr1:38156652 C1orf109 -0.51 -7.18 -0.37 4.74e-12 Prostate cancer (SNP x SNP interaction); CRC trans rs2243480 0.908 rs4718273 chr7:65216099 G/A cg10756647 chr7:56101905 PSPH -0.71 -7.56 -0.38 4.01e-13 Diabetic kidney disease; CRC trans rs2189609 0.521 rs2526066 chr16:74037837 A/C cg26398333 chr1:153895721 GATAD2B -0.44 -6.02 -0.31 4.58e-9 Energy expenditure (24h); CRC trans rs7726839 0.540 rs3749615 chr5:601485 C/T cg11887960 chr12:57824829 NA 0.59 6.59 0.34 1.72e-10 Obesity-related traits; CRC cis rs6951245 1.000 rs78143408 chr7:1096846 G/A cg04025307 chr7:1156635 C7orf50 0.63 6.74 0.35 7.02e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs71403859 0.730 rs17356316 chr16:71746921 C/T cg08717414 chr16:71523259 ZNF19 -0.98 -8.48 -0.42 7.5e-16 Post bronchodilator FEV1; CRC cis rs6964587 0.626 rs10243083 chr7:91552530 G/A cg17063962 chr7:91808500 NA -0.6 -9.67 -0.47 1.27e-19 Breast cancer; CRC cis rs13217239 0.646 rs6456767 chr6:27070543 C/T cg11262757 chr6:27280423 POM121L2 0.27 5.66 0.3 3.24e-8 Schizophrenia; CRC cis rs7731657 0.537 rs72801738 chr5:130207637 A/G cg08523029 chr5:130500466 HINT1 -0.47 -6.11 -0.32 2.84e-9 Fasting plasma glucose; CRC cis rs13108904 0.967 rs4642180 chr4:1278914 T/C cg16405210 chr4:1374714 KIAA1530 -0.46 -6.29 -0.33 1.04e-9 Obesity-related traits; CRC cis rs9549367 0.713 rs3024757 chr13:113823186 G/T cg24300038 chr13:113819356 PROZ -0.46 -5.69 -0.3 2.84e-8 Platelet distribution width; CRC cis rs798554 0.759 rs2644291 chr7:2890456 T/C cg19717773 chr7:2847554 GNA12 -0.49 -6.82 -0.35 4.32e-11 Height; CRC cis rs941873 0.838 rs2233713 chr10:81107135 A/C cg09469691 chr10:81107165 PPIF 0.59 9.68 0.47 1.18e-19 Height; CRC cis rs1129187 0.755 rs9471988 chr6:42944773 T/C cg02353165 chr6:42928485 GNMT 0.72 12.06 0.55 5.75e-28 Alzheimer's disease in APOE e4+ carriers; CRC cis rs10504229 1.000 rs72650892 chr8:58179714 A/G cg24829409 chr8:58192753 C8orf71 -0.68 -11.34 -0.53 2.27e-25 Developmental language disorder (linguistic errors); CRC cis rs1707322 0.686 rs2230659 chr1:46078884 C/T cg03146154 chr1:46216737 IPP -0.69 -9.82 -0.48 3.89e-20 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs4665809 0.549 rs72809635 chr2:26411674 G/A cg25036284 chr2:26402008 FAM59B 0.69 8.24 0.41 4.27e-15 Gut microbiome composition (summer); CRC cis rs7772486 0.790 rs2485632 chr6:146193228 A/G cg23711669 chr6:146136114 FBXO30 0.75 12.95 0.58 2.77e-31 Lobe attachment (rater-scored or self-reported); CRC cis rs1153858 1.000 rs66939267 chr15:45676902 T/A cg10760299 chr15:45669010 GATM 0.49 7.65 0.39 2.19e-13 Homoarginine levels; CRC cis rs2758596 0.850 rs2241110 chr1:156172487 A/G cg24450063 chr1:156163899 SLC25A44 0.74 7.16 0.37 5.39e-12 Paclitaxel disposition in epithelial ovarian cancer; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg13321609 chr19:36119900 RBM42 0.49 6.96 0.36 1.8e-11 Response to antipsychotic treatment; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg18231159 chr7:99214508 ZNF498 0.41 6.61 0.34 1.51e-10 Liver disease severity in Alagille syndrome; CRC cis rs79349575 0.783 rs2112617 chr17:46977125 G/A cg22482690 chr17:47019901 SNF8 0.45 7.34 0.38 1.71e-12 Type 2 diabetes; CRC cis rs2839186 0.872 rs13052233 chr21:47707284 G/T cg09417038 chr21:47716443 C21orf57 -0.42 -6.91 -0.36 2.59e-11 Testicular germ cell tumor; CRC cis rs11229555 0.874 rs10896788 chr11:58292976 G/A cg15696309 chr11:58395628 NA -0.94 -12.69 -0.57 2.71e-30 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; CRC cis rs9916302 0.800 rs9892675 chr17:37549200 C/T cg15445000 chr17:37608096 MED1 -0.41 -8.12 -0.41 9.27e-15 Glomerular filtration rate (creatinine); CRC cis rs2836974 0.899 rs34978594 chr21:40580003 C/T cg06238570 chr21:40685208 BRWD1 0.78 10.77 0.51 2.25e-23 Cognitive function; CRC cis rs34172651 0.517 rs12927710 chr16:24790282 A/C cg02428538 chr16:24856791 SLC5A11 -0.6 -6.83 -0.35 4.09e-11 Intelligence (multi-trait analysis); CRC cis rs10504229 0.679 rs111843870 chr8:58126798 A/G cg02290350 chr8:58132656 NA -0.58 -8.16 -0.41 7.29e-15 Developmental language disorder (linguistic errors); CRC trans rs1814175 0.817 rs7947286 chr11:49874657 C/T cg21153622 chr11:89784906 NA -0.38 -6.04 -0.32 4.27e-9 Height; CRC cis rs501916 0.761 rs589889 chr15:48019016 C/G cg16110827 chr15:48056943 SEMA6D -0.49 -7.7 -0.39 1.58e-13 Inflammatory bowel disease;Ulcerative colitis; CRC cis rs561341 1.000 rs561341 chr17:30316385 T/G cg19193384 chr17:30244184 NA -0.65 -7.49 -0.38 6.27e-13 Hip circumference adjusted for BMI; CRC cis rs501120 0.810 rs684666 chr10:44745847 T/C cg09554077 chr10:44749378 NA 0.9 13.3 0.59 1.4e-32 Coronary artery disease;Coronary heart disease; CRC cis rs1448094 0.511 rs7959372 chr12:86160680 T/C cg02569458 chr12:86230093 RASSF9 0.47 7.83 0.4 6.84e-14 Major depressive disorder; CRC trans rs2303319 0.504 rs62189041 chr2:162599506 T/C cg22988483 chr14:93581567 ITPK1 -0.66 -6.07 -0.32 3.52e-9 Cognitive function; CRC cis rs2836974 0.627 rs9981301 chr21:40686078 G/C cg06238570 chr21:40685208 BRWD1 -0.85 -13.5 -0.6 2.41e-33 Cognitive function; CRC cis rs2882667 0.931 rs10068237 chr5:138337960 T/A cg09476006 chr5:138032270 NA 0.43 7.23 0.37 3.5e-12 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs6761276 0.899 rs11677043 chr2:113835520 A/G cg24553058 chr2:113831203 IL1F10 0.39 6.26 0.33 1.18e-9 Protein quantitative trait loci; CRC cis rs780096 0.526 rs10182937 chr2:27651693 T/C cg17158414 chr2:27665306 KRTCAP3 -0.3 -6.51 -0.34 2.82e-10 Total body bone mineral density; CRC cis rs10911232 0.507 rs10797815 chr1:182996827 A/G ch.1.3577855R chr1:183094577 LAMC1 0.86 15.15 0.64 1.1e-39 Hypertriglyceridemia; CRC cis rs6089584 0.927 rs1886007 chr20:60581049 G/A cg06108461 chr20:60628389 TAF4 -0.69 -11.57 -0.54 3.25e-26 Body mass index; CRC cis rs7119 0.717 rs35284122 chr15:77804568 G/T cg10437265 chr15:77819839 NA 0.67 11.9 0.55 2.1e-27 Type 2 diabetes; CRC cis rs10046574 0.731 rs6961685 chr7:135115985 T/C cg27474649 chr7:135195673 CNOT4 0.69 5.71 0.3 2.49e-8 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs9916302 0.706 rs9909304 chr17:37500508 G/T cg07936489 chr17:37558343 FBXL20 0.91 11.44 0.53 9.34e-26 Glomerular filtration rate (creatinine); CRC cis rs4253772 0.591 rs6008362 chr22:46652737 G/A cg09491104 chr22:46646882 C22orf40 -0.49 -7.62 -0.39 2.7e-13 LDL cholesterol;Cholesterol, total; CRC cis rs7727544 0.735 rs2569266 chr5:131706791 T/C cg07395648 chr5:131743802 NA 0.43 6.69 0.35 9.41e-11 Blood metabolite levels; CRC cis rs644799 0.965 rs11021310 chr11:95502106 A/C cg03916912 chr11:95522834 CEP57;FAM76B 0.95 17.5 0.69 6.2e-49 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs13191362 0.938 rs35211042 chr6:162998703 A/G cg21926612 chr6:163149169 PACRG;PARK2 0.77 11.26 0.53 4.18e-25 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs1547553 1 rs1547553 chr18:77926197 C/A cg14906638 chr18:78001859 PARD6G -0.68 -7.54 -0.38 4.67e-13 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs9768139 0.903 rs28503558 chr7:158119568 C/T cg23298862 chr7:158159286 PTPRN2 -0.48 -7.92 -0.4 3.58e-14 Calcium levels; CRC cis rs76878669 0.561 rs11227465 chr11:66115879 T/A cg18002602 chr11:66138449 SLC29A2 -0.3 -6.21 -0.32 1.58e-9 Educational attainment (years of education); CRC cis rs9303280 0.806 rs4795395 chr17:37962987 T/A cg00129232 chr17:37814104 STARD3 -0.45 -7.39 -0.38 1.19e-12 Self-reported allergy; CRC cis rs9303401 0.659 rs714959 chr17:56628601 A/G cg02118635 chr17:56770003 RAD51C;TEX14 0.75 9.52 0.46 3.75e-19 Cognitive test performance; CRC trans rs7613875 0.578 rs2526749 chr3:50076734 A/G cg21659725 chr3:3221576 CRBN -0.46 -6.84 -0.35 3.92e-11 Body mass index; CRC cis rs896854 0.608 rs7004862 chr8:95876963 T/G cg09323728 chr8:95962352 TP53INP1 -0.38 -5.98 -0.31 5.66e-9 Type 2 diabetes; CRC cis rs17270561 0.887 rs12201170 chr6:25866247 A/G cg16482183 chr6:26056742 HIST1H1C 0.89 10.18 0.49 2.48e-21 Iron status biomarkers; CRC cis rs10504229 1.000 rs59549824 chr8:58186205 A/C cg02290350 chr8:58132656 NA -0.42 -6.02 -0.31 4.7e-9 Developmental language disorder (linguistic errors); CRC cis rs7666738 0.830 rs1593573 chr4:98925293 T/C cg05340658 chr4:99064831 C4orf37 0.6 9.35 0.46 1.41e-18 Colonoscopy-negative controls vs population controls; CRC trans rs800082 0.507 rs2575183 chr3:144260523 C/T cg24215973 chr2:240111563 HDAC4 0.44 6.08 0.32 3.25e-9 Smoking behavior; CRC cis rs270601 0.837 rs367805 chr5:131701279 T/C cg12564285 chr5:131593104 PDLIM4 0.44 7.41 0.38 1.06e-12 Acylcarnitine levels; CRC cis rs17713451 0.542 rs73475440 chr7:151279385 A/G cg18404559 chr7:151322523 PRKAG2 -0.54 -6.27 -0.33 1.13e-9 Interleukin-4 levels; CRC cis rs11148252 0.774 rs7993748 chr13:52941631 C/T cg12458913 chr13:53173898 NA 0.54 8.81 0.44 7.38e-17 Lewy body disease; CRC cis rs2836974 1.000 rs12710454 chr21:40656919 A/G cg17971929 chr21:40555470 PSMG1 0.72 9.78 0.47 5.23e-20 Cognitive function; CRC cis rs2576037 0.523 rs4890705 chr18:44509758 A/G cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.57 -8.45 -0.42 9.39e-16 Personality dimensions; CRC trans rs9858542 0.953 rs7646366 chr3:49470668 G/A cg21665057 chr3:196295764 WDR53;FBXO45 -0.63 -8.63 -0.43 2.58e-16 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs3768617 0.510 rs3768616 chr1:183103551 T/C ch.1.3577855R chr1:183094577 LAMC1 0.85 14.49 0.62 3.95e-37 Fuchs's corneal dystrophy; CRC cis rs9311474 0.713 rs352167 chr3:52238656 C/T cg15147215 chr3:52552868 STAB1 0.49 8.13 0.41 8.58e-15 Electroencephalogram traits; CRC cis rs72772090 0.634 rs72773906 chr5:96092274 C/G cg17330273 chr5:96107758 CAST;ERAP1 -0.68 -6.55 -0.34 2.22e-10 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs13064411 0.696 rs6438159 chr3:113217341 T/C cg10517650 chr3:113235015 CCDC52 -0.41 -7.18 -0.37 4.55e-12 Response to simvastatin treatment (PCSK9 protein level change); CRC cis rs6598955 0.640 rs6667826 chr1:26531408 T/C cg00852783 chr1:26633632 UBXN11 0.46 7.24 0.37 3.25e-12 Obesity-related traits; CRC cis rs1707322 1.000 rs12097799 chr1:46459886 C/A cg06784218 chr1:46089804 CCDC17 0.52 9.2 0.45 4.11e-18 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs13256369 1.000 rs12550458 chr8:8567832 G/A cg18904891 chr8:8559673 CLDN23 0.52 6.89 0.35 2.9e-11 Obesity-related traits; CRC cis rs4478858 0.647 rs11577679 chr1:31726185 T/C cg00250761 chr1:31883323 NA -0.45 -8.81 -0.44 7.53e-17 Alcohol dependence; CRC cis rs6582630 0.555 rs1829583 chr12:38423161 T/C cg13010199 chr12:38710504 ALG10B -0.46 -6.54 -0.34 2.3e-10 Drug-induced liver injury (flucloxacillin); CRC cis rs11711311 0.747 rs2895415 chr3:113345565 A/G cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.52 -6.9 -0.36 2.73e-11 IgG glycosylation; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg25134909 chr11:47587211 PTPMT1 0.45 6.83 0.35 4.15e-11 Intelligence (multi-trait analysis); CRC cis rs7617480 0.617 rs7610519 chr3:48746427 C/G cg07636037 chr3:49044803 WDR6 0.71 8.86 0.44 5.26e-17 Subjective well-being (multi-trait analysis);Menarche (age at onset); CRC cis rs11229555 0.874 rs11601687 chr11:58338628 T/C cg15696309 chr11:58395628 NA -0.95 -12.73 -0.57 1.82e-30 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; CRC cis rs644799 1.000 rs527899 chr11:95529242 T/G cg03916912 chr11:95522834 CEP57;FAM76B 0.95 18.15 0.71 1.71e-51 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs3885907 1.000 rs9508832 chr13:31314264 G/A cg19953038 chr13:31306303 NA -0.36 -5.95 -0.31 6.96e-9 Adverse response to chemotherapy in breast cancer (alopecia) (cyclophosphamide+epirubicin+/-5FU); CRC cis rs60871478 0.947 rs62432255 chr7:804219 G/A cg05535760 chr7:792225 HEATR2 0.8 10.57 0.5 1.09e-22 Cerebrospinal P-tau181p levels; CRC cis rs62244186 0.516 rs11922470 chr3:44777795 C/T cg15225532 chr3:44803084 KIF15;KIAA1143 0.61 9.03 0.45 1.48e-17 Depressive symptoms; CRC trans rs1656966 1.000 rs1656966 chr3:186466252 C/T cg19812495 chr5:71616193 MRPS27;PTCD2 0.4 5.99 0.31 5.53e-9 Myopia (pathological); CRC cis rs11690935 0.885 rs7602037 chr2:172817794 G/A cg13550731 chr2:172543902 DYNC1I2 -1.02 -16.26 -0.67 5e-44 Schizophrenia; CRC cis rs6964587 0.967 rs2299235 chr7:91627500 C/T cg17063962 chr7:91808500 NA 0.8 14.14 0.61 8.7e-36 Breast cancer; CRC trans rs9858542 0.953 rs34363169 chr3:49537712 G/A cg21659725 chr3:3221576 CRBN -0.66 -8.98 -0.44 2.18e-17 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs7647973 1.000 rs2312462 chr3:49601255 A/G cg07690219 chr3:49449608 TCTA;RHOA -0.5 -5.76 -0.3 1.92e-8 Menarche (age at onset); CRC cis rs45509595 0.841 rs370155 chr6:27782031 T/G cg19041857 chr6:27730383 NA -0.74 -7.3 -0.37 2.23e-12 Breast cancer; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg05882699 chr10:126840591 CTBP2 0.35 6.07 0.32 3.48e-9 Liver disease severity in Alagille syndrome; CRC cis rs55883249 1.000 rs76964971 chr2:9763904 C/A cg23886495 chr2:9695866 ADAM17 0.51 5.87 0.31 1.05e-8 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; CRC cis rs3008870 1.000 rs2985818 chr1:67398916 G/A cg08660285 chr1:67390436 MIER1;WDR78 1.02 15.1 0.64 1.64e-39 Lymphocyte percentage of white cells; CRC trans rs7395662 1.000 rs10838954 chr11:48579323 C/T cg21153622 chr11:89784906 NA -0.43 -6.88 -0.35 3.06e-11 HDL cholesterol; CRC cis rs883565 0.916 rs12636980 chr3:39124132 C/T cg01426195 chr3:39028469 NA 0.45 6.45 0.33 4.03e-10 Handedness; CRC cis rs1801251 1.000 rs56777991 chr2:233635388 A/C cg25237894 chr2:233734115 C2orf82 0.5 8.22 0.41 4.87e-15 Coronary artery disease; CRC cis rs651907 0.535 rs13094753 chr3:101525082 A/G cg11279151 chr3:101281821 RG9MTD1 -0.53 -7.09 -0.36 8.3e-12 Colorectal cancer; CRC cis rs1218582 0.741 rs10908444 chr1:154840287 G/A cg03351412 chr1:154909251 PMVK 0.53 8.63 0.43 2.72e-16 Prostate cancer; CRC cis rs9487051 0.872 rs9386791 chr6:109608497 C/T cg21918786 chr6:109611834 NA -0.44 -8.06 -0.41 1.45e-14 Reticulocyte fraction of red cells; CRC cis rs6662572 0.686 rs72677541 chr1:46561560 C/T cg08644498 chr1:46502608 NA 0.45 7.18 0.37 4.64e-12 Blood protein levels; CRC trans rs2980436 1 rs2980436 chr8:8092025 A/G cg16141378 chr3:129829833 LOC729375 0.51 7.37 0.38 1.39e-12 Schizophrenia; CRC cis rs6831352 0.918 rs17218108 chr4:100055755 T/C cg12011299 chr4:100065546 ADH4 -0.49 -9.27 -0.45 2.61e-18 Alcohol dependence; CRC cis rs7089973 0.872 rs7909657 chr10:116629096 C/G cg03647239 chr10:116582469 FAM160B1 0.41 5.79 0.3 1.67e-8 Bipolar disorder or attention deficit hyperactivity disorder; CRC cis rs6570726 0.935 rs585292 chr6:145862228 T/C cg05347473 chr6:146136440 FBXO30 0.38 6.05 0.32 4e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs4332037 0.624 rs73046339 chr7:1889300 G/A cg23378565 chr7:2036160 MAD1L1 -0.4 -6.13 -0.32 2.48e-9 Bipolar disorder; CRC cis rs1552244 1.000 rs2160869 chr3:10079255 G/A cg10729496 chr3:10149963 C3orf24 0.5 6.81 0.35 4.65e-11 Alzheimer's disease; CRC trans rs35110281 0.748 rs2838322 chr21:44998615 G/C cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.52 8.71 0.43 1.55e-16 Mean corpuscular volume; CRC cis rs7666738 0.830 rs11097605 chr4:98985167 T/C cg17366294 chr4:99064904 C4orf37 0.43 7.21 0.37 3.91e-12 Colonoscopy-negative controls vs population controls; CRC cis rs2692947 0.740 rs4907280 chr2:96402126 A/G cg23100626 chr2:96804247 ASTL 0.26 6.76 0.35 6.45e-11 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; CRC cis rs597539 0.552 rs10896384 chr11:68720011 A/G cg04772025 chr11:68637568 NA -0.44 -6.91 -0.36 2.47e-11 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs3733585 0.699 rs4515163 chr4:9959603 C/T cg11266682 chr4:10021025 SLC2A9 -0.47 -9.67 -0.47 1.2e-19 Cleft plate (environmental tobacco smoke interaction); CRC cis rs4713675 0.584 rs942643 chr6:33668370 A/G cg14003231 chr6:33640908 ITPR3 0.5 8.02 0.4 1.82e-14 Plateletcrit; CRC cis rs9910055 0.762 rs11080007 chr17:42265442 A/G cg09913183 chr17:42254507 C17orf65;ASB16 -0.6 -8.64 -0.43 2.54e-16 Total body bone mineral density; CRC cis rs4713118 0.621 rs4713132 chr6:28034035 A/G cg12963246 chr6:28129442 ZNF389 0.47 5.77 0.3 1.84e-8 Parkinson's disease; CRC cis rs4588572 0.643 rs1560197 chr5:77768302 T/C cg11547950 chr5:77652471 NA -0.53 -7.2 -0.37 4.12e-12 Triglycerides; CRC trans rs10802346 0.514 rs4443861 chr1:246372574 G/T cg22732515 chr19:44031385 ETHE1 0.61 9.07 0.45 1.1e-17 Fractional exhaled nitric oxide (childhood); CRC cis rs305851 0.875 rs9394629 chr6:39758362 A/G cg02386599 chr6:39769542 DAAM2 0.38 6.06 0.32 3.67e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs6662572 0.906 rs76438782 chr1:46240425 C/A cg03123370 chr1:45965343 CCDC163P;MMACHC 0.47 6.07 0.32 3.53e-9 Blood protein levels; CRC cis rs7301826 0.651 rs1973834 chr12:131280157 C/T cg11011512 chr12:131303247 STX2 0.39 5.82 0.31 1.41e-8 Plasma plasminogen activator levels; CRC cis rs2160860 0.736 rs7845418 chr8:39800005 C/A cg11363097 chr8:39792086 IDO2 -0.45 -7.65 -0.39 2.28e-13 Blood metabolite levels; CRC trans rs9650657 0.537 rs11250092 chr8:10786543 A/G cg06636001 chr8:8085503 FLJ10661 0.61 8.93 0.44 3.1e-17 Neuroticism; CRC cis rs1707322 1.000 rs6695421 chr1:46380207 T/C cg06784218 chr1:46089804 CCDC17 0.52 9.12 0.45 7.88e-18 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs55702914 0.837 rs2195507 chr2:198172336 T/C cg20885578 chr2:198174922 NA -0.35 -6.07 -0.32 3.56e-9 Major depression and alcohol dependence; CRC cis rs10504229 0.775 rs55825382 chr8:58157605 G/A cg02290350 chr8:58132656 NA -0.51 -6.35 -0.33 7.11e-10 Developmental language disorder (linguistic errors); CRC cis rs1215050 0.740 rs2695464 chr4:98980929 T/C cg05340658 chr4:99064831 C4orf37 -0.48 -7.19 -0.37 4.35e-12 Waist-to-hip ratio adjusted for body mass index; CRC cis rs9487051 0.898 rs882072 chr6:109611806 A/G cg21918786 chr6:109611834 NA -0.45 -8.22 -0.41 4.68e-15 Reticulocyte fraction of red cells; CRC cis rs7647973 1.000 rs3905330 chr3:49550774 A/G cg07690219 chr3:49449608 TCTA;RHOA -0.52 -6.17 -0.32 1.96e-9 Menarche (age at onset); CRC cis rs972578 1.000 rs738377 chr22:43389570 C/T cg01576275 chr22:43409880 NA -0.49 -7.91 -0.4 3.96e-14 Mean platelet volume; CRC cis rs9487051 0.872 rs9480923 chr6:109607369 G/C cg21918786 chr6:109611834 NA -0.45 -8.25 -0.41 3.94e-15 Reticulocyte fraction of red cells; CRC cis rs1552244 0.554 rs2272121 chr3:10047680 A/G cg08888203 chr3:10149979 C3orf24 0.48 7.28 0.37 2.52e-12 Alzheimer's disease; CRC cis rs7586879 0.765 rs6545758 chr2:25074874 C/T cg04586622 chr2:25135609 ADCY3 0.48 8.2 0.41 5.28e-15 Body mass index; CRC cis rs78456975 0.527 rs4073862 chr2:1563433 A/G cg12573674 chr2:1569213 NA -0.85 -10.94 -0.52 6e-24 Placebo response in major depressive disorder (% change in symptom score); CRC cis rs11958404 0.517 rs35212858 chr5:157238942 T/C cg05962755 chr5:157440814 NA 0.75 8.89 0.44 4.15e-17 IgG glycosylation; CRC cis rs4862750 0.872 rs6830828 chr4:187897472 T/G cg27532560 chr4:187881888 NA -0.56 -10.23 -0.49 1.63e-21 Lobe attachment (rater-scored or self-reported); CRC cis rs17767294 0.611 rs66487884 chr6:28202912 C/G cg03623178 chr6:28175578 NA 0.82 7.73 0.39 1.35e-13 Parkinson's disease; CRC cis rs9921222 0.521 rs757460 chr16:367174 G/C cg12437481 chr16:420112 MRPL28 -0.56 -7.35 -0.38 1.58e-12 Bone mineral density (spine);Bone mineral density; CRC trans rs1005277 0.579 rs176880 chr10:38401417 C/G cg27523141 chr10:43048294 ZNF37B -0.49 -7.24 -0.37 3.25e-12 Extrinsic epigenetic age acceleration; CRC cis rs9399135 0.967 rs17638970 chr6:135320063 A/G cg22676075 chr6:135203613 NA 0.42 6.51 0.34 2.78e-10 Red blood cell count; CRC cis rs35146811 0.660 rs3779045 chr7:99779259 T/C cg00553149 chr7:99775558 STAG3;GPC2 0.24 5.9 0.31 8.81e-9 Coronary artery disease; CRC trans rs2303319 0.504 rs56965753 chr2:162597251 A/G cg14875682 chr5:52083620 ITGA1;PELO -0.73 -6.16 -0.32 2.11e-9 Cognitive function; CRC cis rs514406 0.825 rs6588441 chr1:53223494 G/A cg24675658 chr1:53192096 ZYG11B 0.53 7.8 0.39 8.34e-14 Monocyte count; CRC cis rs3806843 0.735 rs2530241 chr5:140054485 C/T cg16607685 chr5:140181889 PCDHA2;PCDHA1;PCDHA3 0.26 5.87 0.31 1.06e-8 Depressive symptoms (multi-trait analysis); CRC cis rs6479527 0.875 rs7045643 chr9:96822071 G/T cg14459158 chr9:96720562 NA 0.36 6.47 0.34 3.62e-10 Esophageal adenocarcinoma; CRC cis rs9549367 0.756 rs9603814 chr13:113900782 C/T cg18105134 chr13:113819100 PROZ 0.7 11.02 0.52 2.97e-24 Platelet distribution width; CRC cis rs951366 0.764 rs708725 chr1:205744138 G/T cg17178900 chr1:205818956 PM20D1 0.68 10.18 0.49 2.4e-21 Menarche (age at onset); CRC cis rs1105228 0.819 rs573814 chr6:165713998 C/T cg20535254 chr6:165714960 C6orf118 -0.3 -6.17 -0.32 2.01e-9 Number of pregnancies;Number of children; CRC cis rs939574 0.790 rs79225383 chr2:220093972 C/A cg00496455 chr2:220118770 TUBA4A;TUBA4B 0.91 8.44 0.42 1.06e-15 Platelet distribution width; CRC cis rs6076065 0.707 rs2424555 chr20:23417705 A/G cg11657817 chr20:23433608 CST11 0.53 8.78 0.44 9.29e-17 Facial morphology (factor 15, philtrum width); CRC trans rs9291683 0.588 rs3796829 chr4:10019138 C/G cg26043149 chr18:55253948 FECH 0.51 7.91 0.4 3.95e-14 Bone mineral density; CRC cis rs12135062 0.901 rs2651928 chr1:3101722 C/T cg21609526 chr1:3105151 PRDM16 -0.57 -9.77 -0.47 5.85e-20 Migraine; CRC cis rs72627123 0.867 rs73303116 chr14:74483615 C/T cg12022184 chr14:74485813 ENTPD5;C14orf45 0.71 5.81 0.3 1.5e-8 Morning vs. evening chronotype; CRC cis rs7666738 0.830 rs7662596 chr4:99019962 G/T cg17366294 chr4:99064904 C4orf37 0.43 7.29 0.37 2.28e-12 Colonoscopy-negative controls vs population controls; CRC cis rs7727544 0.654 rs4705849 chr5:131559199 T/A cg09877947 chr5:131593287 PDLIM4 0.36 6.55 0.34 2.26e-10 Blood metabolite levels; CRC cis rs72945132 0.882 rs12289915 chr11:70131956 G/C cg14191688 chr11:70257035 CTTN 0.4 5.62 0.3 4.07e-8 Coronary artery disease; CRC cis rs597539 0.616 rs631001 chr11:68642974 C/T cg04772025 chr11:68637568 NA 0.49 7.16 0.37 5.29e-12 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs798554 0.757 rs1182198 chr7:2862906 C/T cg17321639 chr7:2759063 NA -0.54 -7.05 -0.36 1.04e-11 Height; CRC cis rs501120 0.584 rs11591406 chr10:44690710 G/A cg09554077 chr10:44749378 NA 0.68 7.33 0.37 1.78e-12 Coronary artery disease;Coronary heart disease; CRC cis rs910316 0.967 rs11159116 chr14:75550584 G/T cg03030879 chr14:75389066 RPS6KL1 -0.46 -7.33 -0.37 1.8e-12 Height; CRC cis rs6502050 0.835 rs4789754 chr17:80091941 C/T cg19223190 chr17:80058835 NA 0.39 6.12 0.32 2.66e-9 Life satisfaction; CRC cis rs2032447 0.869 rs2230655 chr6:26033506 A/G cg12310025 chr6:25882481 NA 0.52 7.25 0.37 2.96e-12 Intelligence (multi-trait analysis); CRC cis rs4713118 0.513 rs149959 chr6:28013854 T/C cg12273811 chr6:28175739 NA 0.56 8.01 0.4 1.98e-14 Parkinson's disease; CRC trans rs7618501 0.602 rs34831713 chr3:50118748 T/C cg21659725 chr3:3221576 CRBN -0.54 -8.58 -0.43 3.76e-16 Intelligence (multi-trait analysis); CRC cis rs55665837 1.000 rs10466412 chr11:14505189 A/T cg19336497 chr11:14380999 RRAS2 -0.38 -6.49 -0.34 3.18e-10 Vitamin D levels; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg16857181 chr7:32931955 KBTBD2 0.44 6.22 0.32 1.55e-9 Response to antipsychotic treatment; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg07630564 chr3:128445061 RAB7A 0.42 7.04 0.36 1.15e-11 Liver disease severity in Alagille syndrome; CRC cis rs11785400 0.793 rs4736362 chr8:143741381 G/A cg10596483 chr8:143751796 JRK 0.43 5.82 0.31 1.39e-8 Schizophrenia; CRC cis rs1451375 0.617 rs10276473 chr7:50612997 A/C cg14593290 chr7:50529359 DDC -0.61 -8.19 -0.41 5.78e-15 Malaria; CRC cis rs2708977 0.933 rs6576972 chr2:97152446 C/T cg01950434 chr2:97203154 ARID5A -0.41 -5.99 -0.31 5.41e-9 Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes; CRC cis rs10256972 0.521 rs871019 chr7:1105230 A/G cg07308232 chr7:1071921 C7orf50 -0.41 -5.93 -0.31 7.47e-9 Longevity;Endometriosis; CRC cis rs7626444 0.625 rs843535 chr3:196473064 G/A cg12930392 chr3:196481615 PAK2 0.4 7.05 0.36 1.07e-11 Monocyte count; CRC cis rs780096 0.526 rs1647266 chr2:27693485 T/C cg12648201 chr2:27665141 KRTCAP3 -0.31 -6.28 -0.33 1.05e-9 Total body bone mineral density; CRC cis rs9894429 1.000 rs7222241 chr17:79574714 C/G cg13777783 chr17:79615861 NA -0.3 -5.69 -0.3 2.77e-8 Eye color traits; CRC cis rs1018836 0.923 rs9694450 chr8:91618292 G/A cg16814680 chr8:91681699 NA -0.75 -11.59 -0.54 2.85e-26 Ejection fraction in Tripanosoma cruzi seropositivity; CRC cis rs13108904 0.967 rs11730939 chr4:1285560 G/A cg21620606 chr4:1342894 KIAA1530 0.35 5.75 0.3 2.04e-8 Obesity-related traits; CRC cis rs7259376 0.936 rs55983151 chr19:22552936 T/A cg02657401 chr19:22469223 NA -0.31 -6.76 -0.35 6.13e-11 Menopause (age at onset); CRC cis rs7224685 0.569 rs8082483 chr17:4000849 G/A cg11204139 chr17:3907470 NA 0.51 6.5 0.34 3.06e-10 Type 2 diabetes; CRC cis rs6580649 0.943 rs9651993 chr12:48404692 G/A cg05342945 chr12:48394962 COL2A1 -0.44 -5.93 -0.31 7.86e-9 Lung cancer; CRC cis rs2276314 0.857 rs6507158 chr18:33636066 A/C cg05985134 chr18:33552581 C18orf21 0.51 7.33 0.37 1.85e-12 Endometriosis;Drug-induced torsades de pointes; CRC cis rs6951245 0.554 rs75075857 chr7:1140298 C/T cg26224354 chr7:1096374 C7orf50;GPR146 -0.59 -7.99 -0.4 2.37e-14 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs9322193 0.962 rs62439843 chr6:149997657 T/C cg05861140 chr6:150128134 PCMT1 -0.43 -6.93 -0.36 2.17e-11 Lung cancer; CRC cis rs1865760 0.588 rs9467658 chr6:26010881 T/G cg18357526 chr6:26021779 HIST1H4A 0.42 6.08 0.32 3.24e-9 Height; CRC cis rs754466 0.651 rs11818687 chr10:79637709 C/T cg26805224 chr10:79626177 DLG5 -0.55 -8.24 -0.41 4.24e-15 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs644799 1.000 rs487609 chr11:95588102 T/G cg25622487 chr11:95524042 FAM76B;CEP57 0.75 11.68 0.54 1.37e-26 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs4819052 0.851 rs875621 chr21:46682295 A/G cg19498844 chr21:46707878 POFUT2;LOC642852 0.77 11.14 0.52 1.17e-24 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC trans rs10802346 0.545 rs1361408 chr1:246410054 T/G cg22732515 chr19:44031385 ETHE1 0.71 11.23 0.53 5.35e-25 Fractional exhaled nitric oxide (childhood); CRC trans rs2303319 0.504 rs62189054 chr2:162624654 C/G cg12500891 chr11:57225987 NA -0.65 -6.05 -0.32 3.87e-9 Cognitive function; CRC cis rs12286929 0.609 rs11602686 chr11:115100638 G/A cg04055981 chr11:115044050 NA 0.37 5.7 0.3 2.6e-8 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs3106136 0.933 rs34383543 chr4:95163792 T/C cg11021082 chr4:95130006 SMARCAD1 -0.46 -7.15 -0.37 5.67e-12 Capecitabine sensitivity; CRC cis rs7487075 1.000 rs7487075 chr12:46828918 G/A cg17501823 chr12:47219793 SLC38A4 0.31 5.68 0.3 3.03e-8 Itch intensity from mosquito bite; CRC cis rs881375 1.000 rs10818480 chr9:123643170 T/C cg14255062 chr9:123606675 PSMD5;LOC253039 0.42 6.12 0.32 2.64e-9 Rheumatoid arthritis; CRC cis rs7429990 0.965 rs62260764 chr3:47990500 G/C cg11946769 chr3:48343235 NME6 0.57 6.66 0.34 1.14e-10 Educational attainment (years of education); CRC cis rs919433 0.713 rs55642934 chr2:198491110 C/T cg10820045 chr2:198174542 NA 0.4 6.83 0.35 4e-11 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC cis rs7647973 0.667 rs4241405 chr3:49642027 C/T cg03060546 chr3:49711283 APEH 0.66 7.69 0.39 1.69e-13 Menarche (age at onset); CRC cis rs970548 0.688 rs2082111 chr10:45931060 A/C cg15590007 chr10:45870220 ALOX5 0.64 6.67 0.35 1.09e-10 Total cholesterol levels;Cholesterol, total;HDL cholesterol;HDL cholesterol levels; CRC cis rs3820068 0.603 rs3795763 chr1:15959977 C/T cg13390004 chr1:15929781 NA 0.5 7.06 0.36 1.02e-11 Systolic blood pressure; CRC cis rs2239547 0.657 rs7620706 chr3:52891756 A/T cg18404041 chr3:52824283 ITIH1 -0.4 -7.31 -0.37 1.99e-12 Schizophrenia; CRC cis rs853679 0.517 rs9368551 chr6:28061792 A/G cg25164649 chr6:28176230 NA 0.75 9.36 0.46 1.32e-18 Depression; CRC cis rs12497850 0.931 rs9840684 chr3:48893780 T/C cg07636037 chr3:49044803 WDR6 1.03 18.15 0.71 1.69e-51 Parkinson's disease; CRC cis rs344364 0.511 rs2982455 chr16:1950498 T/G cg14074117 chr16:1909714 C16orf73 0.41 5.63 0.3 3.77e-8 Glomerular filtration rate in chronic kidney disease; CRC trans rs16957091 0.528 rs66932813 chr15:43088622 T/G cg15973384 chr6:168817498 NA 0.52 6.06 0.32 3.75e-9 MGMT methylation in smokers; CRC cis rs8077889 0.871 rs16940243 chr17:41900003 C/G cg26893861 chr17:41843967 DUSP3 0.9 13.17 0.59 4.25e-32 Triglycerides; CRC cis rs4604732 0.631 rs12039642 chr1:247624898 A/G cg12754571 chr1:247694271 LOC148824;OR2C3 0.41 5.78 0.3 1.74e-8 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CRC cis rs4481887 0.893 rs9651175 chr1:248446888 G/T cg13385794 chr1:248469461 NA 0.38 6.65 0.34 1.24e-10 Common traits (Other); CRC cis rs77861329 1.000 rs9847073 chr3:52144947 C/T cg08692210 chr3:52188851 WDR51A -0.83 -7.81 -0.4 7.54e-14 Macrophage inflammatory protein 1b levels; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg27014642 chr1:109791839 CELSR2 0.48 6.27 0.33 1.12e-9 Thyroid stimulating hormone; CRC cis rs1577917 0.958 rs11755864 chr6:86691791 A/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.52 -6.8 -0.35 4.97e-11 Response to antipsychotic treatment; CRC trans rs2303319 0.504 rs62187611 chr2:162431946 A/G cg10498984 chr16:28874827 SH2B1 -0.73 -5.99 -0.31 5.54e-9 Cognitive function; CRC cis rs79349575 0.811 rs60708039 chr17:46999373 C/G cg00947319 chr17:47005597 UBE2Z -0.34 -5.87 -0.31 1.06e-8 Type 2 diabetes; CRC trans rs7819412 1.000 rs7819412 chr8:11045161 A/G cg16141378 chr3:129829833 LOC729375 -0.41 -6.09 -0.32 3.18e-9 Triglycerides; CRC cis rs798554 0.757 rs2533882 chr7:2846894 G/T cg19717773 chr7:2847554 GNA12 -0.49 -6.85 -0.35 3.64e-11 Height; CRC cis rs4843747 0.605 rs28399183 chr16:88107277 G/A cg17633681 chr16:88106987 BANP 0.87 15.92 0.66 1.06e-42 Menopause (age at onset); CRC cis rs9807989 0.729 rs10170583 chr2:102974764 G/A cg03938978 chr2:103052716 IL18RAP 0.37 6.07 0.32 3.47e-9 Asthma; CRC trans rs41997 0.785 rs2110215 chr7:118071216 C/T cg20503117 chr3:5164013 ARL8B -0.63 -6.19 -0.32 1.76e-9 Response to platinum-based chemotherapy in non-small-cell lung cancer; CRC cis rs172166 0.652 rs476167 chr6:28065888 T/C cg03623178 chr6:28175578 NA 0.8 11.88 0.55 2.41e-27 Cardiac Troponin-T levels; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg12115800 chr3:73144435 NA 0.3 6.08 0.32 3.38e-9 Liver disease severity in Alagille syndrome; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg07058086 chr8:29120186 KIF13B 0.38 6.14 0.32 2.37e-9 Liver disease severity in Alagille syndrome; CRC cis rs853679 0.517 rs2273564 chr6:28057594 A/T cg15845792 chr6:28175446 NA 0.98 13.03 0.58 1.45e-31 Depression; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg00884529 chr7:16685823 BZW2;ANKMY2 0.48 6.44 0.33 4.32e-10 Thyroid stimulating hormone; CRC cis rs7552404 0.960 rs4949877 chr1:76201668 C/G cg22875332 chr1:76189707 ACADM 0.69 9.24 0.45 3.13e-18 Blood metabolite levels;Acylcarnitine levels; CRC cis rs9611519 0.603 rs9607764 chr22:41411804 G/C cg03806693 chr22:41940476 POLR3H -0.41 -5.75 -0.3 2.02e-8 Neuroticism; CRC cis rs9914988 0.778 rs9907185 chr17:27122414 C/T cg20469991 chr17:27169893 C17orf63 -0.6 -7.27 -0.37 2.59e-12 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs798554 0.836 rs13243214 chr7:2817455 G/T cg14895029 chr7:2775587 GNA12 -0.46 -6.67 -0.35 1.09e-10 Height; CRC cis rs17345786 1.000 rs11715368 chr3:101336380 G/A cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.59 6.91 0.36 2.52e-11 Colonoscopy-negative controls vs population controls; CRC cis rs9322193 0.923 rs10872650 chr6:150082095 A/G cg00933542 chr6:150070202 PCMT1 0.33 6.77 0.35 5.78e-11 Lung cancer; CRC cis rs6570726 0.791 rs401331 chr6:145831408 A/G cg13319975 chr6:146136371 FBXO30 -0.44 -6.61 -0.34 1.53e-10 Lobe attachment (rater-scored or self-reported); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg08847724 chr12:12420135 LRP6 0.44 6.2 0.32 1.7e-9 Response to antipsychotic treatment; CRC cis rs7259376 0.775 rs7257134 chr19:22540857 A/T cg02657401 chr19:22469223 NA -0.35 -7.52 -0.38 5.33e-13 Menopause (age at onset); CRC cis rs853679 0.517 rs9393894 chr6:28112562 A/G cg23161317 chr6:28129485 ZNF389 0.53 6.43 0.33 4.52e-10 Depression; CRC cis rs2153535 0.580 rs2183112 chr6:8528212 G/A cg07606381 chr6:8435919 SLC35B3 0.67 10.85 0.51 1.15e-23 Motion sickness; CRC cis rs4664293 0.510 rs1968343 chr2:160568758 C/T cg08347373 chr2:160653686 CD302 0.36 5.94 0.31 7.21e-9 Monocyte percentage of white cells; CRC cis rs2084637 1.000 rs10892852 chr11:122390440 C/T cg21585512 chr11:122030076 LOC399959 -0.41 -7.5 -0.38 5.96e-13 Stroke; CRC cis rs6952808 0.895 rs12669518 chr7:1921429 G/C cg00106254 chr7:1943704 MAD1L1 -0.46 -7.04 -0.36 1.11e-11 Bipolar disorder and schizophrenia; CRC cis rs4676482 0.578 rs784504 chr3:39195260 G/C cg02254461 chr3:39195904 CSRNP1 -0.64 -8.82 -0.44 7.04e-17 Colonoscopy-negative controls vs population controls; CRC cis rs1881797 1.000 rs12063141 chr1:247688343 G/A cg21399703 chr1:247681439 NA 0.5 7.99 0.4 2.23e-14 Acute lymphoblastic leukemia (childhood); CRC cis rs6743376 0.532 rs2515395 chr2:113818702 G/C cg24553058 chr2:113831203 IL1F10 0.43 6.96 0.36 1.81e-11 Inflammatory biomarkers; CRC cis rs1552244 1.000 rs9875081 chr3:10083935 G/A cg16606324 chr3:10149918 C3orf24 0.7 9.66 0.47 1.31e-19 Alzheimer's disease; CRC cis rs561341 1.000 rs530209 chr17:30315287 A/G cg19193384 chr17:30244184 NA -0.65 -7.49 -0.38 6.27e-13 Hip circumference adjusted for BMI; CRC cis rs7811142 1.000 rs6975514 chr7:100056220 T/C cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.75 10.17 0.49 2.66e-21 Platelet count; CRC cis rs1153858 1.000 rs7171577 chr15:45627979 G/A cg21132104 chr15:45694354 SPATA5L1 0.57 8.31 0.42 2.54e-15 Homoarginine levels; CRC cis rs11098499 0.754 rs1511017 chr4:120250805 G/A cg24375607 chr4:120327624 NA 0.47 7.6 0.39 3.06e-13 Corneal astigmatism; CRC cis rs7833790 0.750 rs10108955 chr8:82690644 C/T cg17211192 chr8:82754475 SNX16 -0.5 -6.22 -0.32 1.47e-9 Diastolic blood pressure; CRC cis rs11792861 0.851 rs17552292 chr9:111891954 C/T cg05043794 chr9:111880884 C9orf5 -0.35 -6.48 -0.34 3.41e-10 Menarche (age at onset); CRC cis rs561341 0.739 rs6505267 chr17:30225950 A/C cg12193833 chr17:30244370 NA -0.46 -6.26 -0.33 1.17e-9 Hip circumference adjusted for BMI; CRC cis rs858239 1.000 rs156421 chr7:23312487 A/G cg00469287 chr7:23338798 C7orf30 0.49 6.51 0.34 2.78e-10 Cerebrospinal fluid biomarker levels; CRC cis rs1223397 0.938 rs9381884 chr6:13278788 A/G cg06879394 chr6:13274151 PHACTR1 0.47 5.77 0.3 1.79e-8 Blood pressure; CRC cis rs9611565 0.559 rs12483860 chr22:41961916 C/T cg06634786 chr22:41940651 POLR3H -0.52 -6.07 -0.32 3.46e-9 Vitiligo; CRC cis rs12505749 0.542 rs6554358 chr4:57372576 A/T cg06922635 chr4:57371607 ARL9 -0.54 -5.72 -0.3 2.35e-8 Airflow obstruction; CRC cis rs1577917 0.883 rs9450348 chr6:86598036 T/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.45 -5.92 -0.31 8.07e-9 Response to antipsychotic treatment; CRC cis rs6912958 0.781 rs9444519 chr6:88290398 T/C cg08069147 chr6:88032118 GJB7;C6orf162 -0.57 -8.57 -0.43 4.19e-16 Monocyte percentage of white cells; CRC cis rs853679 0.517 rs9357061 chr6:28051772 A/G cg12172441 chr6:28176163 NA 0.6 7.2 0.37 4.23e-12 Depression; CRC cis rs2075371 0.931 rs1646697 chr7:133999930 G/A cg02659138 chr7:134003124 SLC35B4 0.42 7.36 0.38 1.49e-12 Mean platelet volume; CRC cis rs681343 1.000 rs679574 chr19:49206108 C/G cg01656853 chr19:49199172 FUT2 0.23 5.62 0.3 4.1e-8 Lung adenocarcinoma;Primary sclerosing cholangitis;Childhood ear infection; CRC trans rs877282 0.898 rs11253348 chr10:765852 C/T cg22713356 chr15:30763199 NA 1.3 15.02 0.64 3.32e-39 Uric acid levels; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg19952228 chr3:122102923 FAM162A;CCDC58 0.44 6.33 0.33 8.08e-10 Anxiety disorder; CRC cis rs11792861 0.888 rs72607168 chr9:111832192 G/C cg05043794 chr9:111880884 C9orf5 -0.37 -6.62 -0.34 1.43e-10 Menarche (age at onset); CRC cis rs1707322 1.000 rs3922886 chr1:46473902 A/T cg06784218 chr1:46089804 CCDC17 0.52 9.14 0.45 6.52e-18 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs2836950 0.565 rs2836945 chr21:40596757 C/T cg17971929 chr21:40555470 PSMG1 -0.6 -8.89 -0.44 4e-17 Menarche (age at onset); CRC trans rs617791 0.569 rs11227370 chr11:65747693 C/T cg17712092 chr4:129076599 LARP1B -0.48 -7.0 -0.36 1.46e-11 Breast cancer; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg08050352 chr16:46864715 C16orf87 0.41 6.08 0.32 3.36e-9 Intelligence (multi-trait analysis); CRC cis rs9902453 0.872 rs34698290 chr17:28500465 A/G cg26525008 chr17:28256777 EFCAB5;SSH2 0.56 8.42 0.42 1.15e-15 Coffee consumption (cups per day); CRC trans rs4263408 0.934 rs9683743 chr4:39703194 A/C cg07951519 chr17:4607306 PELP1 -0.41 -6.04 -0.32 4.09e-9 Plasma amyloid beta peptide concentrations (ABx-40); CRC trans rs1455244 0.700 rs7229302 chr18:11508904 G/T cg05612640 chr18:77748679 TXNL4A 0.4 5.98 0.31 5.73e-9 Schizophrenia; CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg24725560 chr11:32605793 EIF3M -0.5 -6.08 -0.32 3.28e-9 Diisocyanate-induced asthma; CRC cis rs6701037 0.512 rs2285216 chr1:175133012 C/T cg14847009 chr1:175162515 KIAA0040 0.3 6.67 0.34 1.11e-10 Alcohol dependence; CRC cis rs6089584 0.927 rs2281734 chr20:60582401 C/A cg18761221 chr20:60518478 NA 0.4 6.89 0.36 2.83e-11 Body mass index; CRC cis rs12024301 0.557 rs12042646 chr1:183614282 C/T cg11505048 chr1:183622726 RGL1;APOBEC4 -0.68 -6.38 -0.33 5.97e-10 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs2976388 0.507 rs2572874 chr8:143837219 C/T cg22687807 chr8:143858763 LYNX1 0.59 10.54 0.5 1.39e-22 Urinary tract infection frequency; CRC cis rs7107174 1.000 rs2244508 chr11:77948515 T/A cg02023728 chr11:77925099 USP35 0.5 7.64 0.39 2.43e-13 Testicular germ cell tumor; CRC cis rs9517320 0.515 rs61969456 chr13:99174799 C/G cg07423050 chr13:99094983 FARP1 -0.56 -8.11 -0.41 9.83e-15 Longevity; CRC cis rs889398 0.617 rs1566456 chr16:69900226 G/C cg00738113 chr16:70207722 CLEC18C -0.34 -5.9 -0.31 8.81e-9 Body mass index; CRC cis rs910316 0.737 rs108621 chr14:75480637 T/C cg08847533 chr14:75593920 NEK9 -0.84 -14.48 -0.62 4.13e-37 Height; CRC cis rs2811415 0.627 rs1042911 chr3:127789594 T/G cg13719885 chr3:127795394 NA -0.4 -6.05 -0.32 3.83e-9 Lung function (FEV1/FVC); CRC trans rs2303319 0.504 rs72877343 chr2:162607487 A/C cg12500891 chr11:57225987 NA -0.65 -6.06 -0.32 3.77e-9 Cognitive function; CRC cis rs1129187 0.755 rs9471988 chr6:42944773 T/C cg00597713 chr6:42947103 PEX6 -0.4 -5.62 -0.3 4.18e-8 Alzheimer's disease in APOE e4+ carriers; CRC trans rs10242455 0.702 rs45461000 chr7:99052710 A/G cg09045935 chr12:6379348 NA 1.14 8.98 0.44 2.21e-17 Blood metabolite levels; CRC cis rs1707322 0.717 rs3014245 chr1:46086913 C/T cg03146154 chr1:46216737 IPP -0.65 -9.19 -0.45 4.59e-18 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs40363 0.645 rs1690446 chr16:3519009 T/C cg05754148 chr16:3507555 NAT15 0.54 7.36 0.38 1.44e-12 Tuberculosis; CRC trans rs360798 0.512 rs2710640 chr2:63144305 A/G cg05376469 chr2:102649931 NA -0.38 -6.32 -0.33 8.43e-10 Coronary artery disease; CRC cis rs4919694 1.000 rs12246689 chr10:104817031 C/T cg04362960 chr10:104952993 NT5C2 1.11 10.44 0.5 3.09e-22 Arsenic metabolism; CRC cis rs2535633 0.661 rs4515041 chr3:52996032 T/A cg11645453 chr3:52864694 ITIH4 -0.4 -7.47 -0.38 7.52e-13 Body mass index; CRC cis rs16852403 0.619 rs10913509 chr1:178122784 C/G cg00404053 chr1:178313656 RASAL2 0.59 7.54 0.38 4.58e-13 Childhood ear infection; CRC cis rs17401966 1.000 rs60743860 chr1:10442926 G/C cg19773385 chr1:10388646 KIF1B -0.56 -7.38 -0.38 1.3e-12 Hepatocellular carcinoma; CRC cis rs733592 0.524 rs10875726 chr12:48425992 A/G cg21466736 chr12:48725269 NA 0.49 7.72 0.39 1.41e-13 Plateletcrit; CRC cis rs17376456 0.877 rs10062711 chr5:93348659 G/A cg09848695 chr5:92956644 FAM172A;MIR2277 0.64 5.74 0.3 2.14e-8 Diabetic retinopathy; CRC cis rs6804368 0.553 rs7617829 chr3:30769948 C/T cg06106510 chr3:30762233 NA 0.35 5.6 0.3 4.45e-8 Blood metabolite levels; CRC cis rs12971120 0.783 rs7229256 chr18:72169129 T/A cg26446133 chr18:72167187 CNDP2 -0.76 -15.24 -0.64 4.77e-40 Refractive error; CRC cis rs7394190 0.748 rs4746139 chr10:75407649 A/C cg07699608 chr10:75541558 CHCHD1 0.61 6.21 0.32 1.57e-9 Incident atrial fibrillation; CRC cis rs6582630 0.599 rs12309369 chr12:38419683 C/G cg26384229 chr12:38710491 ALG10B -0.52 -7.51 -0.38 5.69e-13 Drug-induced liver injury (flucloxacillin); CRC cis rs9491140 0.539 rs11154228 chr6:124686042 A/G cg05308643 chr6:124982296 NKAIN2 0.48 6.66 0.34 1.17e-10 Neuroticism; CRC cis rs9902453 0.765 rs2250320 chr17:28128657 G/C cg26525008 chr17:28256777 EFCAB5;SSH2 -0.73 -12.22 -0.56 1.39e-28 Coffee consumption (cups per day); CRC cis rs1997103 1.000 rs4947499 chr7:55407196 T/C cg17469321 chr7:55412551 NA 0.72 11.28 0.53 3.48e-25 QRS interval (sulfonylurea treatment interaction); CRC cis rs3796352 0.568 rs11713376 chr3:52958927 A/G cg06204229 chr3:52865917 ITIH4 0.52 6.66 0.34 1.13e-10 Immune reponse to smallpox (secreted IL-2); CRC cis rs2730245 0.527 rs1188971 chr7:158664463 G/T cg24397884 chr7:158709396 WDR60 0.9 11.08 0.52 1.82e-24 Height; CRC cis rs597539 0.652 rs611046 chr11:68631704 A/G cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.85 14.03 0.61 2.31e-35 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs7932354 0.528 rs1965952 chr11:47181040 G/A cg19486271 chr11:47235900 DDB2 0.44 6.32 0.33 8.73e-10 Bone mineral density (hip);Bone mineral density; CRC cis rs875971 1.000 rs6970030 chr7:65968679 T/C cg12463550 chr7:65579703 CRCP 0.47 6.79 0.35 5.17e-11 Aortic root size; CRC cis rs8141529 1.000 rs132534 chr22:29299806 T/C cg15103426 chr22:29168792 CCDC117 -0.44 -5.9 -0.31 9.02e-9 Lymphocyte counts; CRC cis rs79349575 0.783 rs4399576 chr17:47009835 G/A cg22482690 chr17:47019901 SNF8 0.48 8.01 0.4 2e-14 Type 2 diabetes; CRC cis rs9916302 0.904 rs8068427 chr17:37511517 G/A cg07936489 chr17:37558343 FBXL20 0.82 12.31 0.56 6.59e-29 Glomerular filtration rate (creatinine); CRC trans rs1814175 0.817 rs1996982 chr11:49972619 G/T cg15704280 chr7:45808275 SEPT13 -1.02 -20.61 -0.75 3.5e-61 Height; CRC cis rs2070677 0.935 rs4582924 chr10:135409033 T/G cg16964102 chr10:135390573 NA 0.52 7.05 0.36 1.04e-11 Gout; CRC trans rs3808502 0.605 rs11784572 chr8:11174484 C/G cg06636001 chr8:8085503 FLJ10661 -0.44 -6.25 -0.33 1.29e-9 Neuroticism; CRC cis rs478304 0.934 rs603645 chr11:65533000 A/C cg08755490 chr11:65554678 OVOL1 0.42 6.15 0.32 2.24e-9 Acne (severe); CRC cis rs7615952 0.576 rs4646759 chr3:125822946 G/C cg02772935 chr3:125709198 NA -0.49 -5.71 -0.3 2.46e-8 Blood pressure (smoking interaction); CRC cis rs9341808 0.718 rs9443735 chr6:80820474 G/T cg08355045 chr6:80787529 NA 0.43 6.88 0.35 2.95e-11 Sitting height ratio; CRC cis rs7937682 0.632 rs3944619 chr11:111774743 A/G cg19812747 chr11:111475976 SIK2 0.43 6.3 0.33 9.57e-10 Primary sclerosing cholangitis; CRC cis rs7584330 0.554 rs79213383 chr2:238426890 A/G cg08992911 chr2:238395768 MLPH 0.47 5.75 0.3 2.04e-8 Prostate cancer; CRC trans rs798502 0.541 rs2644307 chr7:2832973 G/A cg04264129 chr7:80682238 NA -0.4 -6.3 -0.33 9.45e-10 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Inflammatory bowel disease;Waist circumference adjusted for BMI in non-smokers;Ulcerative colitis;Waist circumference adjusted for body mass index;Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction); CRC cis rs9640161 0.659 rs7788316 chr7:150013995 A/T cg13722127 chr7:150037890 RARRES2 0.47 7.81 0.4 7.65e-14 Blood protein levels;Circulating chemerin levels; CRC cis rs6429082 0.818 rs61836206 chr1:235638754 C/G cg26050004 chr1:235667680 B3GALNT2 0.59 7.97 0.4 2.71e-14 Adiposity; CRC cis rs1218582 0.741 rs7544528 chr1:154844585 C/T cg16680214 chr1:154839983 KCNN3 -0.5 -9.98 -0.48 1.18e-20 Prostate cancer; CRC cis rs2153535 0.580 rs7755284 chr6:8457479 T/C cg07606381 chr6:8435919 SLC35B3 0.69 11.13 0.52 1.26e-24 Motion sickness; CRC cis rs2077654 0.822 rs12293228 chr11:17436951 C/T cg25308976 chr11:17434268 ABCC8 0.64 6.57 0.34 2.03e-10 Gout; CRC cis rs12711979 0.740 rs6711963 chr2:3820915 A/T cg17052675 chr2:3827356 NA -0.57 -10.83 -0.51 1.38e-23 Itch intensity from mosquito bite adjusted by bite size; CRC cis rs2688482 0.557 rs2550236 chr3:195522321 A/G cg18918831 chr3:195489782 MUC4 0.68 7.94 0.4 3.13e-14 Lung disease severity in cystic fibrosis; CRC trans rs1814175 0.588 rs10466497 chr11:49864381 A/T cg15704280 chr7:45808275 SEPT13 -0.94 -16.36 -0.67 1.93e-44 Height; CRC cis rs17362650 1.000 rs13032363 chr2:9620740 T/C cg12832956 chr2:9616023 IAH1 -0.5 -6.13 -0.32 2.55e-9 Alcohol dependence (age at onset); CRC cis rs883565 0.740 rs2293312 chr3:39111140 C/A cg01426195 chr3:39028469 NA -0.54 -8.65 -0.43 2.36e-16 Handedness; CRC cis rs4819052 0.851 rs2838855 chr21:46680566 C/G cg02159808 chr21:46707872 POFUT2;LOC642852 -0.52 -6.89 -0.36 2.87e-11 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs1949733 0.598 rs869602 chr4:8535371 G/T cg11789530 chr4:8429930 ACOX3 -0.57 -7.94 -0.4 3.17e-14 Response to antineoplastic agents; CRC trans rs2303319 0.504 rs55841284 chr2:162560011 A/G cg09481857 chr22:21368659 P2RX6;MGC16703 -0.61 -5.99 -0.31 5.62e-9 Cognitive function; CRC cis rs4862750 0.914 rs6553028 chr4:187876046 T/C cg27532560 chr4:187881888 NA -0.55 -9.77 -0.47 6.02e-20 Lobe attachment (rater-scored or self-reported); CRC cis rs1712517 0.771 rs2008530 chr10:105058839 G/A cg05636881 chr10:105038444 INA 0.46 7.82 0.4 7.09e-14 Migraine; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg12376772 chr13:32526694 EEF1DP3 -0.4 -6.5 -0.34 2.93e-10 Liver disease severity in Alagille syndrome; CRC cis rs2739330 0.791 rs4822458 chr22:24265659 C/T cg18538332 chr22:24372958 LOC391322 -0.67 -10.49 -0.5 2.04e-22 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs12760731 0.720 rs67857740 chr1:178402250 A/G cg00404053 chr1:178313656 RASAL2 0.98 10.07 0.49 5.63e-21 Obesity-related traits; CRC cis rs1552244 1.000 rs17032396 chr3:10153559 A/G cg18598329 chr3:10140678 FANCD2;C3orf24 0.88 11.72 0.54 9.6e-27 Alzheimer's disease; CRC cis rs763121 0.853 rs9306329 chr22:39072454 C/T cg06022373 chr22:39101656 GTPBP1 0.8 12.62 0.57 4.84e-30 Menopause (age at onset); CRC cis rs3087591 0.960 rs2953000 chr17:29509791 C/T cg24425628 chr17:29625626 OMG;NF1 0.84 16.01 0.66 4.45e-43 Hip circumference; CRC cis rs7772486 0.686 rs9403739 chr6:146015357 A/G cg13319975 chr6:146136371 FBXO30 0.44 6.56 0.34 2.11e-10 Lobe attachment (rater-scored or self-reported); CRC cis rs7927771 0.800 rs55876153 chr11:47416636 G/A cg05585544 chr11:47624801 NA -0.55 -9.67 -0.47 1.2e-19 Subjective well-being; CRC cis rs7959452 0.562 rs10878975 chr12:69782044 G/C cg14784868 chr12:69753453 YEATS4 0.84 14.68 0.63 7.14e-38 Blood protein levels; CRC cis rs12497850 0.931 rs9755490 chr3:48871664 A/C cg07636037 chr3:49044803 WDR6 1.03 18.15 0.71 1.69e-51 Parkinson's disease; CRC cis rs977987 0.800 rs4888378 chr16:75332041 A/G cg03315344 chr16:75512273 CHST6 0.54 9.05 0.45 1.24e-17 Dupuytren's disease; CRC cis rs7113874 0.569 rs11041999 chr11:8605739 T/C cg20771178 chr11:8615675 STK33 0.35 5.72 0.3 2.37e-8 Body mass index in physically active individuals;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs10504229 0.683 rs6999984 chr8:58115079 G/A cg24829409 chr8:58192753 C8orf71 -0.54 -7.94 -0.4 3.33e-14 Developmental language disorder (linguistic errors); CRC trans rs7267979 0.966 rs2257233 chr20:25265984 A/C cg17903999 chr18:56338584 MALT1 0.42 6.84 0.35 3.97e-11 Liver enzyme levels (alkaline phosphatase); CRC cis rs524281 0.861 rs7942894 chr11:65976525 T/C cg16950941 chr11:66035639 RAB1B -0.59 -7.06 -0.36 9.9e-12 Electroencephalogram traits; CRC trans rs6550704 0.687 rs9865314 chr3:22634337 A/G cg07991241 chr10:33269695 NA -0.42 -6.16 -0.32 2.09e-9 Daytime sleep phenotypes; CRC cis rs12762955 0.561 rs6560863 chr10:1013535 C/A cg19847866 chr10:1019161 NA 0.44 6.49 0.34 3.15e-10 Response to angiotensin II receptor blocker therapy; CRC cis rs1124376 0.748 rs6771367 chr3:20160266 A/T cg05072819 chr3:20081367 KAT2B 0.46 5.79 0.3 1.61e-8 Bipolar disorder and schizophrenia; CRC cis rs11098499 0.722 rs10006192 chr4:120263022 T/C cg24375607 chr4:120327624 NA 0.49 7.95 0.4 2.97e-14 Corneal astigmatism; CRC cis rs7772486 0.790 rs9497425 chr6:146234197 G/A cg13319975 chr6:146136371 FBXO30 0.39 5.84 0.31 1.24e-8 Lobe attachment (rater-scored or self-reported); CRC cis rs9368481 0.594 rs7768643 chr6:26891919 C/T cg18867708 chr6:26865862 GUSBL1 0.44 6.37 0.33 6.37e-10 Autism spectrum disorder or schizophrenia; CRC cis rs7927771 0.756 rs10742803 chr11:47439938 A/G cg20307385 chr11:47447363 PSMC3 0.59 8.91 0.44 3.43e-17 Subjective well-being; CRC cis rs72615157 0.634 rs74774557 chr7:99810425 A/G cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.46 5.7 0.3 2.64e-8 Lung function (FEV1/FVC); CRC trans rs61931739 0.500 rs11053246 chr12:34516620 C/T cg26384229 chr12:38710491 ALG10B 0.67 8.79 0.44 8.27e-17 Morning vs. evening chronotype; CRC cis rs4423214 0.840 rs1792229 chr11:71179395 A/G cg05163923 chr11:71159392 DHCR7 -0.66 -7.87 -0.4 5.27e-14 Vitamin D levels; CRC cis rs8114671 0.562 rs6119545 chr20:33522869 T/C cg07148914 chr20:33460835 GGT7 0.4 6.65 0.34 1.21e-10 Height; CRC cis rs921968 0.678 rs689116 chr2:219433888 C/A cg02176678 chr2:219576539 TTLL4 0.49 7.88 0.4 4.73e-14 Mean corpuscular hemoglobin concentration; CRC trans rs12699921 0.632 rs2723552 chr7:17860661 T/G cg15753394 chr6:17282781 RBM24 -0.36 -6.01 -0.31 5.03e-9 Fibrinogen levels; CRC cis rs1881797 0.872 rs12408686 chr1:247691141 C/T cg18198730 chr1:247681584 NA 0.59 9.22 0.45 3.61e-18 Acute lymphoblastic leukemia (childhood); CRC cis rs1552172 0.887 rs2040085 chr1:145651861 G/A cg11743829 chr1:145714124 CD160 -0.42 -6.29 -0.33 1.04e-9 Breast cancer; CRC cis rs10071761 0.513 rs12514679 chr5:40366803 T/G cg09067459 chr5:40385259 NA -0.53 -7.11 -0.37 7.18e-12 Selective IgA deficiency; CRC cis rs708547 0.871 rs2687238 chr4:57880474 C/T cg25525207 chr4:57843836 C4orf14;POLR2B -0.47 -5.79 -0.3 1.69e-8 Response to bleomycin (chromatid breaks); CRC cis rs11190604 0.945 rs2495746 chr10:102328270 T/C cg16342193 chr10:102329863 NA -0.35 -5.9 -0.31 9.06e-9 Palmitoleic acid (16:1n-7) levels; CRC cis rs924607 1.000 rs11746907 chr5:598224 G/A cg04221910 chr5:616842 CEP72 -0.42 -6.93 -0.36 2.22e-11 Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia; CRC cis rs7918232 0.627 rs6482588 chr10:27308307 G/C cg14240646 chr10:27532245 ACBD5 -0.62 -6.9 -0.36 2.73e-11 Breast cancer; CRC cis rs7647973 0.925 rs9881860 chr3:49352522 A/T cg20833759 chr3:49053208 WDR6;DALRD3 0.59 9.0 0.44 1.88e-17 Menarche (age at onset); CRC cis rs853679 0.517 rs35512245 chr6:28079953 T/C cg02683197 chr6:28174875 NA 0.84 10.18 0.49 2.42e-21 Depression; CRC cis rs926938 0.606 rs6537844 chr1:115289295 G/A cg12756093 chr1:115239321 AMPD1 -0.52 -7.27 -0.37 2.56e-12 Autism; CRC cis rs9291683 0.620 rs4383618 chr4:10125151 T/C cg11266682 chr4:10021025 SLC2A9 -0.45 -8.77 -0.44 9.48e-17 Bone mineral density; CRC cis rs11212617 0.905 rs6589007 chr11:108040104 A/G cg01991180 chr11:108092276 ATM;NPAT 0.43 6.44 0.33 4.18e-10 Response to metformin in type 2 diabetes (glycemic); CRC trans rs1005277 0.540 rs1814077 chr10:37992018 G/C cg23533926 chr12:111358616 MYL2 -0.45 -6.59 -0.34 1.79e-10 Extrinsic epigenetic age acceleration; CRC cis rs1129187 0.755 rs9471976 chr6:42920549 G/T cg05552183 chr6:42928497 GNMT 0.52 8.03 0.4 1.75e-14 Alzheimer's disease in APOE e4+ carriers; CRC cis rs13108904 0.837 rs4519749 chr4:1280102 A/G cg00684032 chr4:1343700 KIAA1530 0.48 7.02 0.36 1.3e-11 Obesity-related traits; CRC cis rs2204008 0.606 rs1581358 chr12:38391582 G/T cg26384229 chr12:38710491 ALG10B 0.7 9.13 0.45 7.11e-18 Bladder cancer; CRC cis rs11971779 0.680 rs7795520 chr7:139079207 A/G cg23387468 chr7:139079360 LUC7L2 0.41 7.04 0.36 1.14e-11 Diisocyanate-induced asthma; CRC cis rs6681460 0.934 rs4655635 chr1:67068240 T/G cg02459107 chr1:67143332 SGIP1 0.4 6.88 0.35 3.08e-11 Presence of antiphospholipid antibodies; CRC cis rs908922 0.676 rs6587686 chr1:152528948 C/T cg23254163 chr1:152506842 NA 0.45 9.13 0.45 6.92e-18 Hair morphology; CRC cis rs919433 0.854 rs13013049 chr2:198208664 C/T cg03934865 chr2:198174659 NA -0.39 -5.74 -0.3 2.21e-8 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC cis rs6582630 0.519 rs4406888 chr12:38293312 A/C cg13010199 chr12:38710504 ALG10B 0.46 6.25 0.33 1.25e-9 Drug-induced liver injury (flucloxacillin); CRC cis rs9467711 0.516 rs629444 chr6:25885814 A/G cg08501292 chr6:25962987 TRIM38 -0.81 -8.24 -0.41 4.15e-15 Autism spectrum disorder or schizophrenia; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg02396668 chr19:50528878 VRK3;ZNF473 0.5 6.41 0.33 5.02e-10 Thyroid stimulating hormone; CRC cis rs6694672 0.867 rs1332662 chr1:197108427 A/G cg13682187 chr1:196946512 CFHR5 0.43 6.93 0.36 2.19e-11 Asthma; CRC cis rs4929949 0.901 rs4475924 chr11:8620009 T/C cg17679104 chr11:8615758 STK33 0.34 5.8 0.3 1.59e-8 Body mass index; CRC cis rs9894429 0.646 rs9902264 chr17:79613828 G/A cg21984481 chr17:79567631 NPLOC4 -0.43 -7.41 -0.38 1.08e-12 Eye color traits; CRC trans rs2303319 0.504 rs12467625 chr2:162603387 C/A cg10272801 chr16:14013773 ERCC4 -0.68 -6.07 -0.32 3.49e-9 Cognitive function; CRC trans rs2727020 0.521 rs1909220 chr11:49572109 T/C cg11707556 chr5:10655725 ANKRD33B -0.47 -7.57 -0.39 3.73e-13 Coronary artery disease; CRC cis rs992157 0.560 rs7578940 chr2:219083318 G/T cg00012203 chr2:219082015 ARPC2 -0.55 -8.63 -0.43 2.58e-16 Colorectal cancer; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg06731730 chr16:69788837 NOB1 0.4 6.02 0.31 4.73e-9 Intelligence (multi-trait analysis); CRC cis rs6920965 0.507 rs9385389 chr6:126215486 G/C cg05901451 chr6:126070800 HEY2 -0.39 -5.86 -0.31 1.14e-8 High light scatter reticulocyte count; CRC cis rs79387448 0.745 rs17027442 chr2:103164948 A/G cg09003973 chr2:102972529 NA -0.71 -7.94 -0.4 3.13e-14 Gut microbiota (bacterial taxa); CRC cis rs13108904 0.875 rs73069950 chr4:1276045 C/A cg02018176 chr4:1364513 KIAA1530 -0.48 -8.21 -0.41 5.05e-15 Obesity-related traits; CRC cis rs875971 0.545 rs316305 chr7:65617971 G/A cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.6 -7.78 -0.39 9.41e-14 Aortic root size; CRC cis rs10504229 0.906 rs114627636 chr8:58173732 C/T cg01721255 chr8:58191610 C8orf71 0.61 5.87 0.31 1.05e-8 Developmental language disorder (linguistic errors); CRC cis rs3749237 1.000 rs2307021 chr3:49765483 C/G cg24308560 chr3:49941425 MST1R -0.42 -5.89 -0.31 9.62e-9 Resting heart rate; CRC trans rs11098499 0.662 rs13108589 chr4:120268102 G/C cg25214090 chr10:38739885 LOC399744 0.53 8.23 0.41 4.56e-15 Corneal astigmatism; CRC cis rs2239547 0.522 rs2581801 chr3:52972907 G/T cg11645453 chr3:52864694 ITIH4 -0.52 -9.15 -0.45 5.91e-18 Schizophrenia; CRC cis rs1552244 1.000 rs58275763 chr3:10143274 C/T cg13047869 chr3:10149882 C3orf24 0.56 7.74 0.39 1.21e-13 Alzheimer's disease; CRC cis rs1799949 0.965 rs8176130 chr17:41258043 C/T cg25072359 chr17:41440525 NA 0.46 6.98 0.36 1.62e-11 Menopause (age at onset); CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg07950158 chr19:45874032 ERCC2 0.51 6.58 0.34 1.91e-10 Thyroid stimulating hormone; CRC cis rs5753618 0.583 rs9606839 chr22:31802710 A/C cg07713946 chr22:31675144 LIMK2 0.4 5.95 0.31 6.81e-9 Colorectal cancer; CRC cis rs1218582 0.661 rs4845695 chr1:154911798 A/G cg09359103 chr1:154839909 KCNN3 -0.72 -11.24 -0.53 5.05e-25 Prostate cancer; CRC cis rs1545257 0.505 rs958352 chr2:24634240 A/G cg06627628 chr2:24431161 ITSN2 -0.45 -6.65 -0.34 1.2e-10 Sjögren's syndrome; CRC cis rs6445967 1.000 rs34611088 chr3:58312923 G/A cg23715586 chr3:58305044 RPP14 0.35 5.92 0.31 8.13e-9 Platelet count; CRC trans rs587242 1.000 rs12045626 chr1:96917476 C/T cg10631902 chr5:14652156 NA 0.45 7.05 0.36 1.08e-11 Body mass index (joint analysis main effects and physical activity interaction);Body mass index in physically inactive individuals;Body mass index; CRC cis rs11252926 0.537 rs6560836 chr10:444997 C/T cg03684893 chr10:554711 DIP2C -0.33 -5.65 -0.3 3.42e-8 Psychosis in Alzheimer's disease; CRC cis rs8060686 0.641 rs73598006 chr16:68074454 C/G cg08314208 chr16:67682810 RLTPR -0.5 -6.04 -0.32 4.22e-9 HDL cholesterol;Metabolic syndrome; CRC trans rs208515 0.525 rs12191500 chr6:66668681 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.94 11.9 0.55 2.19e-27 Exhaled nitric oxide levels; CRC cis rs13118159 0.550 rs13123016 chr4:1340889 T/C cg02018176 chr4:1364513 KIAA1530 0.71 11.77 0.54 6.48e-27 Longevity; CRC cis rs25422 0.938 rs62424176 chr6:118798602 T/C cg24463073 chr6:118973353 C6orf204 0.51 6.73 0.35 7.51e-11 Renal cell carcinoma; CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg01149132 chr14:68141218 VTI1B 0.47 7.21 0.37 3.97e-12 Obesity-related traits; CRC cis rs8044868 0.530 rs12932845 chr16:72122765 G/A cg06172871 chr16:72088244 HP 0.4 5.85 0.31 1.18e-8 Body mass index (change over time) in cancer or chronic obstructive pulmonary disease;Body mass index (change over time) in cancer; CRC cis rs9715521 0.867 rs4860465 chr4:59832537 G/T cg11281224 chr4:60001000 NA -0.39 -5.77 -0.3 1.84e-8 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs9648716 1.000 rs2535946 chr7:140538008 C/T cg10747023 chr7:140774559 NA 0.44 5.76 0.3 1.94e-8 Type 2 diabetes; CRC trans rs3858526 0.920 rs11039548 chr11:5930283 G/A cg01505111 chr6:125621795 HDDC2 0.4 6.42 0.33 4.73e-10 DNA methylation (variation); CRC cis rs2153535 0.580 rs6921036 chr6:8455400 G/A cg21535247 chr6:8435926 SLC35B3 0.49 7.38 0.38 1.33e-12 Motion sickness; CRC cis rs597539 0.652 rs507520 chr11:68666054 C/T cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.88 14.78 0.63 3.03e-38 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC trans rs7937682 0.710 rs674230 chr11:111437887 A/G cg18187862 chr3:45730750 SACM1L 0.44 6.28 0.33 1.06e-9 Primary sclerosing cholangitis; CRC cis rs10486722 0.603 rs10250049 chr7:41774118 A/G cg22138096 chr7:41772439 LOC285954 0.39 5.89 0.31 9.49e-9 Pit-and-Fissure caries; CRC cis rs12711979 0.509 rs13021385 chr2:3826387 T/C cg17052675 chr2:3827356 NA -0.86 -21.11 -0.76 3.77e-63 Itch intensity from mosquito bite adjusted by bite size; CRC cis rs17155006 0.702 rs446566 chr7:107730650 A/G cg05962710 chr7:107745446 LAMB4 0.35 5.76 0.3 1.96e-8 Pneumococcal bacteremia; CRC cis rs9393777 0.528 rs9467989 chr6:27064275 C/T cg12292205 chr6:26970375 C6orf41 -0.65 -8.39 -0.42 1.41e-15 Intelligence (multi-trait analysis); CRC trans rs3808502 0.574 rs4841559 chr8:11416885 C/T cg06636001 chr8:8085503 FLJ10661 -0.54 -8.45 -0.42 9.23e-16 Neuroticism; CRC trans rs561341 0.714 rs474455 chr17:30312465 A/T cg27661571 chr11:113659931 NA -0.77 -9.63 -0.47 1.71e-19 Hip circumference adjusted for BMI; CRC cis rs9818758 0.607 rs11710247 chr3:49249800 G/T cg07636037 chr3:49044803 WDR6 -0.65 -5.74 -0.3 2.13e-8 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; CRC cis rs2836974 0.931 rs2836968 chr21:40642386 A/G cg11890956 chr21:40555474 PSMG1 1.11 19.05 0.72 4.69e-55 Cognitive function; CRC cis rs12936587 0.811 rs12945496 chr17:17537197 G/C cg24612305 chr17:17875800 TOM1L2;LRRC48 -0.43 -5.66 -0.3 3.25e-8 Hip circumference;Coronary artery disease or large artery stroke;Coronary heart disease;Coronary artery disease; CRC cis rs4555082 0.834 rs1473672 chr14:105721981 G/T cg10792982 chr14:105748885 BRF1 0.37 6.15 0.32 2.2e-9 Mean platelet volume;Platelet distribution width; CRC cis rs2153535 0.580 rs7341206 chr6:8470489 T/G cg21535247 chr6:8435926 SLC35B3 0.5 7.53 0.38 4.89e-13 Motion sickness; CRC cis rs2404602 0.669 rs9788684 chr15:77194838 A/T cg23625390 chr15:77176239 SCAPER 0.46 6.42 0.33 4.87e-10 Blood metabolite levels; CRC cis rs7680126 0.586 rs7689060 chr4:10305463 C/G cg11266682 chr4:10021025 SLC2A9 0.37 5.91 0.31 8.4e-9 Urate levels in lean individuals;Urate levels in overweight individuals;Urate levels in obese individuals; CRC cis rs8031584 0.678 rs798125 chr15:31116800 C/T cg14829155 chr15:31115871 NA 0.62 9.76 0.47 6.27e-20 Huntington's disease progression; CRC cis rs10504229 0.861 rs6990617 chr8:58182960 G/T cg24829409 chr8:58192753 C8orf71 -0.68 -11.34 -0.53 2.27e-25 Developmental language disorder (linguistic errors); CRC trans rs6951245 0.872 rs75280240 chr7:1058511 C/T cg13565492 chr6:43139072 SRF -0.68 -7.03 -0.36 1.23e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs7647973 0.560 rs7638154 chr3:49299375 C/A cg03060546 chr3:49711283 APEH 0.47 6.73 0.35 7.6e-11 Menarche (age at onset); CRC cis rs3796352 0.881 rs35385050 chr3:52997945 C/A cg27565382 chr3:53032988 SFMBT1 0.78 6.26 0.33 1.21e-9 Immune reponse to smallpox (secreted IL-2); CRC trans rs11098499 0.874 rs6832670 chr4:120118792 A/G cg25214090 chr10:38739885 LOC399744 0.52 7.73 0.39 1.34e-13 Corneal astigmatism; CRC cis rs1997103 1.000 rs1965556 chr7:55403584 C/G cg17469321 chr7:55412551 NA 0.72 11.24 0.53 5.04e-25 QRS interval (sulfonylurea treatment interaction); CRC cis rs910316 1.000 rs10146482 chr14:75574087 C/T cg11812906 chr14:75593930 NEK9 0.64 10.56 0.5 1.26e-22 Height; CRC cis rs8077889 0.917 rs60335331 chr17:41907509 A/G cg16892393 chr17:41919603 NA 0.47 7.16 0.37 5.32e-12 Triglycerides; CRC cis rs9549328 0.589 rs36164841 chr13:113616579 A/G cg17524180 chr13:113633600 MCF2L 0.52 9.39 0.46 1e-18 Systolic blood pressure; CRC cis rs2019137 0.901 rs4849176 chr2:113977936 C/T cg21550016 chr2:113992930 PAX8;LOC440839;LOC654433 -0.51 -7.29 -0.37 2.27e-12 Lymphocyte counts; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg10778271 chr6:64283102 PTP4A1 0.42 5.99 0.31 5.59e-9 Intelligence (multi-trait analysis); CRC cis rs2880765 0.566 rs55899824 chr15:86004091 C/T cg10818794 chr15:86012489 AKAP13 -0.49 -7.73 -0.39 1.28e-13 Coronary artery disease; CRC cis rs2239547 0.522 rs6770957 chr3:52995416 T/C cg10802521 chr3:52805072 NEK4 -0.45 -6.15 -0.32 2.28e-9 Schizophrenia; CRC cis rs2842992 0.692 rs9347342 chr6:160193129 T/C cg16489826 chr6:160211363 TCP1;MRPL18 0.61 9.29 0.46 2.19e-18 Age-related macular degeneration (geographic atrophy); CRC cis rs6504622 0.818 rs9910899 chr17:45034342 G/C cg16759221 chr17:45003025 GOSR2 -0.49 -7.4 -0.38 1.13e-12 Orofacial clefts; CRC cis rs9916302 0.706 rs7208487 chr17:37543449 T/G cg00129232 chr17:37814104 STARD3 0.57 7.04 0.36 1.14e-11 Glomerular filtration rate (creatinine); CRC cis rs17376456 0.825 rs28610997 chr5:93248374 T/C cg21475434 chr5:93447410 FAM172A 0.83 7.81 0.4 7.48e-14 Diabetic retinopathy; CRC cis rs59104589 0.521 rs34506685 chr2:242439988 A/G cg19488206 chr2:242435732 STK25 0.43 6.8 0.35 4.85e-11 Fibrinogen levels; CRC cis rs11650494 0.710 rs8066722 chr17:47475007 A/G cg08112188 chr17:47440006 ZNF652 -0.71 -6.49 -0.34 3.17e-10 Prostate cancer; CRC cis rs2439831 0.850 rs28718261 chr15:44043793 C/G cg02155558 chr15:43621948 ADAL;LCMT2 0.69 7.61 0.39 2.95e-13 Lung cancer in ever smokers; CRC cis rs79349575 0.783 rs4793998 chr17:47019899 C/T cg22482690 chr17:47019901 SNF8 0.48 8.01 0.4 2.01e-14 Type 2 diabetes; CRC cis rs6502050 0.529 rs35585236 chr17:80116641 T/C cg13198984 chr17:80129470 CCDC57 0.45 8.07 0.41 1.3e-14 Life satisfaction; CRC cis rs11958404 0.932 rs6895484 chr5:157429159 T/C cg05962755 chr5:157440814 NA 1.01 12.88 0.58 5.12e-31 IgG glycosylation; CRC cis rs7044106 0.791 rs2416797 chr9:123480600 C/A cg09419670 chr9:123605666 PSMD5;LOC253039 0.69 10.68 0.51 4.61e-23 Hip circumference adjusted for BMI; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg03969997 chr7:73256865 WBSCR27 0.44 6.42 0.33 4.78e-10 Intelligence (multi-trait analysis); CRC cis rs853679 1.000 rs2799079 chr6:28235176 A/C cg15786705 chr6:28176104 NA 0.54 5.94 0.31 7.27e-9 Depression; CRC trans rs7615952 0.641 rs6438951 chr3:125696999 A/G cg07211511 chr3:129823064 LOC729375 -0.78 -11.07 -0.52 1.96e-24 Blood pressure (smoking interaction); CRC cis rs6066835 0.681 rs3092222 chr20:47387628 C/T cg18078177 chr20:47281410 PREX1 0.68 6.03 0.32 4.33e-9 Multiple myeloma; CRC cis rs6662572 0.737 rs4256763 chr1:46379518 A/G cg03123370 chr1:45965343 CCDC163P;MMACHC -0.46 -5.85 -0.31 1.21e-8 Blood protein levels; CRC trans rs2303319 0.504 rs62189041 chr2:162599506 T/C cg22677401 chr17:46026860 NA -0.67 -6.07 -0.32 3.57e-9 Cognitive function; CRC cis rs910316 0.870 rs7147712 chr14:75670707 C/G cg08847533 chr14:75593920 NEK9 -0.8 -13.46 -0.6 3.37e-33 Height; CRC cis rs9457247 0.935 rs1044059 chr6:167369897 C/A cg23791538 chr6:167370224 RNASET2 0.38 5.87 0.31 1.08e-8 Crohn's disease; CRC trans rs7267979 0.903 rs2500400 chr20:25354705 A/G cg17903999 chr18:56338584 MALT1 0.41 6.87 0.35 3.27e-11 Liver enzyme levels (alkaline phosphatase); CRC cis rs7677751 0.767 rs890204 chr4:55064439 C/G cg13615338 chr4:55094005 PDGFRA 0.43 6.16 0.32 2.09e-9 Corneal astigmatism; CRC cis rs7615952 0.576 rs1127717 chr3:125826059 T/C cg15145296 chr3:125709740 NA -0.53 -6.33 -0.33 8.01e-10 Blood pressure (smoking interaction); CRC cis rs1451375 0.572 rs12666409 chr7:50634976 A/T cg14593290 chr7:50529359 DDC -0.54 -6.85 -0.35 3.64e-11 Malaria; CRC cis rs6951245 1.000 rs78628466 chr7:1068453 G/C cg03188948 chr7:1209495 NA 0.63 6.52 0.34 2.64e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs9303401 0.614 rs12948536 chr17:56580413 G/T cg10487724 chr17:56770010 TEX14;RAD51C 0.79 9.78 0.47 5.43e-20 Cognitive test performance; CRC cis rs1580019 0.922 rs34545272 chr7:32460630 C/T cg14728415 chr7:32535168 LSM5;AVL9 0.42 5.71 0.3 2.5e-8 Cognitive ability; CRC cis rs904251 0.523 rs2797794 chr6:37480604 T/C cg01843034 chr6:37503916 NA -0.44 -8.19 -0.41 5.81e-15 Cognitive performance; CRC cis rs17711722 0.727 rs2658585 chr7:65461941 A/T cg00343986 chr7:65444356 GUSB 0.57 8.55 0.43 4.85e-16 Calcium levels; CRC cis rs12753569 0.934 rs6593523 chr1:76486908 C/T cg00791851 chr1:76518896 NA -0.38 -6.69 -0.35 9.43e-11 Personality dimensions; CRC cis rs7590720 1.000 rs7559031 chr2:216902583 A/G cg12620499 chr2:216877984 MREG 0.86 14.23 0.62 3.68e-36 Alcohol dependence; CRC cis rs6460942 0.732 rs73677576 chr7:12286535 G/A cg20607287 chr7:12443886 VWDE -0.54 -5.69 -0.3 2.87e-8 Coronary artery disease; CRC cis rs4700695 0.719 rs27586 chr5:65445873 G/A cg21114390 chr5:65439923 SFRS12 -0.65 -8.66 -0.43 2.2e-16 Facial morphology (factor 19); CRC cis rs10504229 0.683 rs10504221 chr8:58140256 A/G cg04204079 chr8:58130323 NA -0.45 -5.78 -0.3 1.71e-8 Developmental language disorder (linguistic errors); CRC cis rs739401 0.527 rs418832 chr11:3072236 C/T cg25174290 chr11:3078921 CARS 0.49 7.54 0.38 4.54e-13 Longevity; CRC cis rs2019137 0.936 rs4849169 chr2:113953657 A/C cg07594247 chr2:113993304 PAX8;LOC440839;LOC654433 -0.38 -5.6 -0.3 4.42e-8 Lymphocyte counts; CRC cis rs739401 0.619 rs10766480 chr11:2961325 G/A cg05729581 chr11:3078854 CARS -0.51 -7.2 -0.37 4.25e-12 Longevity; CRC cis rs7647973 0.516 rs4308307 chr3:49193216 C/T cg07636037 chr3:49044803 WDR6 0.85 13.17 0.59 4.05e-32 Menarche (age at onset); CRC cis rs853679 0.517 rs9380047 chr6:28037893 G/T cg18032046 chr6:28092343 ZSCAN16 -0.49 -5.83 -0.31 1.31e-8 Depression; CRC cis rs7586879 0.616 rs10203386 chr2:25136866 T/A cg04586622 chr2:25135609 ADCY3 -0.67 -13.25 -0.59 2.06e-32 Body mass index; CRC cis rs12135062 0.687 rs6685614 chr1:3108517 C/T cg21609526 chr1:3105151 PRDM16 0.37 6.34 0.33 7.48e-10 Migraine; CRC cis rs898097 0.690 rs12452304 chr17:80811659 G/A cg15369054 chr17:80825471 TBCD 0.53 8.69 0.43 1.76e-16 Breast cancer; CRC cis rs9811920 0.609 rs793467 chr3:99539664 A/G cg07805332 chr3:99536008 MIR548G;C3orf26 -0.51 -7.61 -0.39 2.86e-13 Axial length; CRC cis rs4727027 0.933 rs10238826 chr7:148830888 A/G cg23583168 chr7:148888333 NA -0.88 -14.83 -0.63 1.87e-38 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC cis rs10504229 0.636 rs72649133 chr8:58054681 G/A cg22535103 chr8:58192502 C8orf71 -0.8 -8.67 -0.43 1.93e-16 Developmental language disorder (linguistic errors); CRC cis rs3772130 0.961 rs1573819 chr3:121469646 A/C cg20356878 chr3:121714668 ILDR1 0.51 7.92 0.4 3.72e-14 Cognitive performance; CRC cis rs6502050 0.835 rs9900072 chr17:80114360 C/G cg09264619 chr17:80180166 NA -0.35 -5.9 -0.31 8.84e-9 Life satisfaction; CRC cis rs11997175 0.574 rs12541661 chr8:33649856 T/G cg04338863 chr8:33670619 NA 0.4 6.84 0.35 3.8e-11 Body mass index; CRC cis rs9928842 0.882 rs9927264 chr16:75260241 T/C cg09066997 chr16:75300724 BCAR1 0.7 6.67 0.35 1.08e-10 Alcoholic chronic pancreatitis; CRC cis rs9486719 0.895 rs12195315 chr6:96905711 T/G cg18709589 chr6:96969512 KIAA0776 -0.52 -5.8 -0.3 1.57e-8 Migraine;Coronary artery disease; CRC trans rs6463739 1.000 rs6972172 chr7:7902214 C/T cg09417038 chr21:47716443 C21orf57 0.4 6.09 0.32 3.12e-9 Small cell lung carcinoma; CRC cis rs2806561 0.704 rs664301 chr1:23522522 C/T cg12483005 chr1:23474871 LUZP1 0.5 7.07 0.36 9.11e-12 Height; CRC cis rs739401 0.572 rs389285 chr11:3062673 G/A cg25174290 chr11:3078921 CARS 0.49 7.39 0.38 1.2e-12 Longevity; CRC cis rs12791968 1.000 rs1005935 chr11:45002498 A/C cg11846598 chr11:44996168 LOC221122 -0.73 -12.91 -0.58 3.85e-31 Inhibitory control; CRC cis rs6933660 0.800 rs9383900 chr6:151782816 A/C cg14262678 chr6:151773367 RMND1;C6orf211 0.54 9.0 0.44 1.89e-17 Menarche (age at onset); CRC cis rs28735056 0.592 rs10853392 chr18:77708781 A/G cg20368463 chr18:77673604 PQLC1 -0.51 -8.25 -0.41 3.77e-15 Schizophrenia; CRC cis rs17376456 0.825 rs35426871 chr5:93291613 C/T cg25358565 chr5:93447407 FAM172A 1.11 10.4 0.5 4.25e-22 Diabetic retinopathy; CRC cis rs9322193 0.923 rs12174035 chr6:150084447 A/T cg05861140 chr6:150128134 PCMT1 -0.39 -6.35 -0.33 7.28e-10 Lung cancer; CRC trans rs2727020 0.729 rs1164685 chr11:49293660 G/A cg15704280 chr7:45808275 SEPT13 0.89 16.05 0.66 3.2e-43 Coronary artery disease; CRC cis rs79349575 0.783 rs4793992 chr17:47008207 A/G cg22482690 chr17:47019901 SNF8 0.48 8.0 0.4 2.13e-14 Type 2 diabetes; CRC cis rs4713118 0.629 rs203887 chr6:28021269 C/T cg18032046 chr6:28092343 ZSCAN16 -0.47 -5.65 -0.3 3.57e-8 Parkinson's disease; CRC cis rs7769051 1.000 rs7765224 chr6:133101624 T/C cg22852734 chr6:133119734 C6orf192 0.93 11.05 0.52 2.33e-24 Type 2 diabetes nephropathy; CRC cis rs1552244 1.000 rs66838678 chr3:10150350 G/A cg16606324 chr3:10149918 C3orf24 0.73 9.63 0.47 1.7e-19 Alzheimer's disease; CRC cis rs10504229 1.000 rs61212428 chr8:58173963 G/A cg24829409 chr8:58192753 C8orf71 -0.68 -11.34 -0.53 2.27e-25 Developmental language disorder (linguistic errors); CRC cis rs1799949 0.501 rs35399157 chr17:41411602 G/C cg01879757 chr17:41196368 BRCA1 -0.44 -6.68 -0.35 1.04e-10 Menopause (age at onset); CRC cis rs9329289 0.632 rs2452187 chr10:2551147 C/G cg15501526 chr10:2543763 NA 0.68 12.65 0.57 3.83e-30 Age-related hearing impairment; CRC cis rs1552244 0.882 rs28366039 chr3:10028988 C/A cg02579736 chr3:10068473 FANCD2;CIDECP 0.9 10.66 0.51 5.6e-23 Alzheimer's disease; CRC cis rs12230513 0.632 rs59213907 chr12:55728911 A/T cg19537932 chr12:55886519 OR6C68 -0.7 -8.74 -0.43 1.21e-16 Contrast sensitivity; CRC cis rs62408225 1.000 rs62408227 chr6:90965171 A/G cg06866423 chr6:90926672 BACH2 0.48 7.89 0.4 4.42e-14 Eosinophil counts;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC cis rs13118159 0.550 rs4974612 chr4:1364543 A/G cg20887711 chr4:1340912 KIAA1530 0.76 11.07 0.52 1.96e-24 Longevity; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg06636316 chr19:30303495 CCNE1 0.39 6.23 0.32 1.46e-9 Liver disease severity in Alagille syndrome; CRC cis rs3733585 0.660 rs13122290 chr4:9933832 A/G cg00071950 chr4:10020882 SLC2A9 -0.63 -11.28 -0.53 3.61e-25 Cleft plate (environmental tobacco smoke interaction); CRC cis rs4843747 0.519 rs12599755 chr16:88107006 A/G cg17633681 chr16:88106987 BANP 0.89 15.44 0.65 7.89e-41 Menopause (age at onset); CRC cis rs2969070 0.867 rs886626 chr7:2498052 A/C cg03277898 chr7:2518824 NA -0.43 -6.21 -0.32 1.57e-9 Diastolic blood pressure; CRC cis rs66887589 0.967 rs13104219 chr4:120438174 G/T cg09307838 chr4:120376055 NA 0.53 8.07 0.41 1.34e-14 Diastolic blood pressure; CRC cis rs40363 0.680 rs72778116 chr16:3530752 A/G cg05754148 chr16:3507555 NAT15 0.67 6.07 0.32 3.5e-9 Tuberculosis; CRC cis rs7208859 0.673 rs28588622 chr17:29245699 G/A cg13385521 chr17:29058706 SUZ12P 0.67 7.89 0.4 4.41e-14 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC trans rs61931739 0.500 rs34061369 chr12:34519283 C/T cg26384229 chr12:38710491 ALG10B 0.67 8.81 0.44 7.35e-17 Morning vs. evening chronotype; CRC trans rs875971 0.545 rs2707851 chr7:66089165 C/T cg02869306 chr7:64672164 INTS4L1 0.42 6.05 0.32 3.85e-9 Aortic root size; CRC cis rs554111 0.963 rs666371 chr1:21041555 A/G cg00373020 chr1:21041521 KIF17 0.39 6.26 0.33 1.21e-9 Facial morphology (factor 17, height of vermillion upper lip); CRC cis rs801193 0.569 rs4717315 chr7:66178325 C/T cg18252515 chr7:66147081 NA -0.42 -6.0 -0.31 5.18e-9 Aortic root size; CRC cis rs1656402 1.000 rs1656402 chr2:233426526 C/T cg03852847 chr2:233439513 NA 0.45 7.66 0.39 2.1e-13 Non-small cell lung cancer (survival); CRC cis rs56399783 0.614 rs116929101 chr7:2760325 G/A cg19731401 chr7:2775893 GNA12 0.69 7.57 0.38 3.89e-13 Childhood ear infection; CRC cis rs514406 0.929 rs557847 chr1:53333116 A/G cg24675658 chr1:53192096 ZYG11B -0.55 -8.36 -0.42 1.83e-15 Monocyte count; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg08524483 chr7:5085471 RBAK 0.43 6.04 0.32 4.22e-9 Response to antipsychotic treatment; CRC cis rs1552244 1.000 rs17032414 chr3:10158302 C/G cg16606324 chr3:10149918 C3orf24 0.66 9.29 0.46 2.19e-18 Alzheimer's disease; CRC cis rs11212617 1.000 rs35244261 chr11:108283808 A/C cg12106634 chr11:108092400 ATM;NPAT -0.39 -5.66 -0.3 3.21e-8 Response to metformin in type 2 diabetes (glycemic); CRC cis rs2404602 0.716 rs56216512 chr15:76686936 T/C cg03037974 chr15:76606532 NA 0.73 13.0 0.58 1.88e-31 Blood metabolite levels; CRC cis rs72781680 0.948 rs72781652 chr2:24213754 G/A cg08917208 chr2:24149416 ATAD2B 0.9 9.11 0.45 8.5e-18 Lymphocyte counts; CRC cis rs7666738 0.800 rs2865987 chr4:99067852 A/C cg05340658 chr4:99064831 C4orf37 0.58 8.9 0.44 3.69e-17 Colonoscopy-negative controls vs population controls; CRC cis rs7620457 1.000 rs7620457 chr3:183747266 A/G cg01324343 chr3:183735012 ABCC5 -0.58 -7.05 -0.36 1.07e-11 Body mass index; CRC cis rs1008375 0.966 rs12509962 chr4:17680292 G/A cg04450456 chr4:17643702 FAM184B 0.4 6.37 0.33 6.42e-10 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs9911578 1.000 rs304292 chr17:56824123 G/A cg12560992 chr17:57184187 TRIM37 0.9 16.62 0.68 1.87e-45 Intelligence (multi-trait analysis); CRC cis rs748404 0.660 rs690512 chr15:43717678 A/G cg02155558 chr15:43621948 ADAL;LCMT2 0.53 7.88 0.4 4.67e-14 Lung cancer; CRC cis rs9847710 0.733 rs11923593 chr3:53088790 A/G cg18099408 chr3:52552593 STAB1 0.42 6.04 0.32 4.25e-9 Ulcerative colitis; CRC cis rs7618915 1.000 rs34569561 chr3:52287293 T/C cg14092988 chr3:52407081 DNAH1 0.38 6.69 0.35 9.33e-11 Bipolar disorder; CRC cis rs854765 0.547 rs4584886 chr17:17896205 C/T cg23957660 chr17:17878224 LRRC48 0.43 8.23 0.41 4.43e-15 Total body bone mineral density; CRC cis rs4722166 0.630 rs7781534 chr7:22778592 A/C cg26061582 chr7:22766209 IL6 0.55 8.35 0.42 1.92e-15 Lung cancer; CRC cis rs2180341 0.751 rs9388553 chr6:127574044 A/G cg27446573 chr6:127587934 RNF146 0.82 12.17 0.56 2.14e-28 Breast cancer; CRC cis rs8180040 0.627 rs6442059 chr3:47187075 C/G cg02527881 chr3:46936655 PTH1R -0.35 -6.09 -0.32 3.07e-9 Colorectal cancer; CRC cis rs9303401 1.000 rs6503877 chr17:56841948 C/T cg10487724 chr17:56770010 TEX14;RAD51C 0.56 8.2 0.41 5.34e-15 Cognitive test performance; CRC cis rs853679 0.542 rs6934769 chr6:28090931 A/G cg25164649 chr6:28176230 NA 0.76 9.53 0.46 3.71e-19 Depression; CRC cis rs875971 1.000 rs2420168 chr7:65630631 C/G cg18876405 chr7:65276391 NA -0.53 -9.23 -0.45 3.49e-18 Aortic root size; CRC cis rs60843830 0.964 rs17713879 chr2:254215 G/A cg25945732 chr2:264204 ACP1;SH3YL1 0.73 11.9 0.55 2.04e-27 Spherical equivalent (joint analysis main effects and education interaction); CRC cis rs11190604 1.000 rs3750629 chr10:102275727 A/G cg07080220 chr10:102295463 HIF1AN 0.46 5.73 0.3 2.26e-8 Palmitoleic acid (16:1n-7) levels; CRC cis rs6502050 0.799 rs7406257 chr17:80089340 G/A cg22110888 chr17:80059540 CCDC57 0.4 6.34 0.33 7.4e-10 Life satisfaction; CRC cis rs6500395 0.775 rs8050844 chr16:48665696 A/G cg04672837 chr16:48644449 N4BP1 0.44 6.53 0.34 2.53e-10 Response to tocilizumab in rheumatoid arthritis; CRC cis rs6754311 0.731 rs2164210 chr2:136580287 T/C cg15123519 chr2:136567270 LCT 0.33 6.39 0.33 5.65e-10 Mosquito bite size; CRC cis rs10078 0.515 rs890984 chr5:479540 A/G cg08916839 chr5:415575 AHRR 0.8 8.1 0.41 1.08e-14 Fat distribution (HIV); CRC cis rs977987 0.843 rs60730309 chr16:75431769 C/G cg03315344 chr16:75512273 CHST6 0.52 8.71 0.43 1.56e-16 Dupuytren's disease; CRC cis rs7503807 1.000 rs8079537 chr17:78600818 A/G cg09596252 chr17:78655493 RPTOR 0.39 6.09 0.32 3.12e-9 Obesity; CRC cis rs911119 0.955 rs4815224 chr20:23594112 C/G cg16589663 chr20:23618590 CST3 0.54 6.92 0.36 2.3e-11 Chronic kidney disease; CRC cis rs2290405 1.000 rs2290405 chr4:946974 A/G cg09237302 chr4:906077 GAK 0.32 6.13 0.32 2.51e-9 Systemic sclerosis; CRC cis rs7208859 0.623 rs7223209 chr17:29107220 C/A cg13385521 chr17:29058706 SUZ12P 0.73 8.4 0.42 1.39e-15 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs9527 0.590 rs2274339 chr10:104860053 T/A cg04362960 chr10:104952993 NT5C2 0.6 8.45 0.42 9.36e-16 Arsenic metabolism; CRC cis rs12476592 0.602 rs262529 chr2:63903892 A/C cg10828910 chr2:63850056 LOC388955 0.51 6.33 0.33 7.99e-10 Childhood ear infection; CRC trans rs9329221 0.683 rs3105738 chr8:9889914 A/T cg06636001 chr8:8085503 FLJ10661 -0.52 -8.25 -0.41 3.85e-15 Neuroticism; CRC cis rs13256369 1.000 rs885000 chr8:8568875 G/T cg06636001 chr8:8085503 FLJ10661 0.49 6.28 0.33 1.05e-9 Obesity-related traits; CRC cis rs4285028 0.898 rs4305455 chr3:121619774 T/C cg20356878 chr3:121714668 ILDR1 -0.46 -6.55 -0.34 2.27e-10 Multiple sclerosis; CRC cis rs910316 0.935 rs3742771 chr14:75599647 A/G cg03030879 chr14:75389066 RPS6KL1 -0.49 -7.59 -0.39 3.36e-13 Height; CRC cis rs3862030 0.503 rs10786673 chr10:104280537 G/A cg04362960 chr10:104952993 NT5C2 -0.42 -5.9 -0.31 8.92e-9 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for body mass index; CRC cis rs873946 0.590 rs12783478 chr10:134550700 A/G cg27286337 chr10:134555280 INPP5A 0.7 9.41 0.46 8.93e-19 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CRC cis rs7591163 1.000 rs4487084 chr2:228713179 G/A cg20647610 chr2:228736258 WDR69 -0.5 -6.76 -0.35 6.37e-11 Blood pressure; CRC cis rs2882667 0.858 rs66839813 chr5:138442322 A/T cg09476006 chr5:138032270 NA 0.44 6.69 0.35 9.76e-11 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs9517320 0.534 rs9556962 chr13:99156648 C/T cg20487152 chr13:99095054 FARP1 -0.47 -6.62 -0.34 1.43e-10 Longevity; CRC trans rs7395662 0.591 rs4882085 chr11:48504569 C/G cg03929089 chr4:120376271 NA -0.45 -6.43 -0.33 4.48e-10 HDL cholesterol; CRC trans rs4714291 0.802 rs2984430 chr6:39983741 A/G cg02267698 chr19:7991119 CTXN1 -0.52 -7.21 -0.37 3.92e-12 Strep throat; CRC cis rs3820068 0.532 rs72647105 chr1:15935238 C/G cg13390004 chr1:15929781 NA 0.5 7.14 0.37 6.11e-12 Systolic blood pressure; CRC cis rs1448094 0.967 rs7974794 chr12:86323280 A/G cg18827107 chr12:86230957 RASSF9 -0.37 -6.1 -0.32 2.98e-9 Major depressive disorder; CRC cis rs4713118 0.869 rs10214440 chr6:27702440 A/C cg19041857 chr6:27730383 NA -0.43 -6.13 -0.32 2.52e-9 Parkinson's disease; CRC cis rs2075371 0.932 rs34664116 chr7:133984878 G/A cg11752832 chr7:134001865 SLC35B4 0.43 6.48 0.34 3.38e-10 Mean platelet volume; CRC cis rs270601 0.739 rs3900945 chr5:131592870 T/C cg18301423 chr5:131593218 PDLIM4 0.45 8.28 0.42 3.06e-15 Acylcarnitine levels; CRC cis rs2731664 0.756 rs335433 chr5:176867207 T/C cg23176889 chr5:176863531 GRK6 -0.73 -15.93 -0.66 9.7e-43 Intelligence (multi-trait analysis); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg02955050 chr19:59070391 UBE2M;LOC100131691 0.38 6.24 0.33 1.36e-9 Liver disease severity in Alagille syndrome; CRC trans rs11098499 0.657 rs71614442 chr4:120379346 C/T cg25214090 chr10:38739885 LOC399744 0.66 10.6 0.5 9.04e-23 Corneal astigmatism; CRC cis rs2839186 0.632 rs2839184 chr21:47689013 G/A cg26721908 chr21:47610096 LSS -0.48 -6.93 -0.36 2.18e-11 Testicular germ cell tumor; CRC cis rs4713118 0.955 rs34752872 chr6:27683244 A/T cg12273811 chr6:28175739 NA 0.54 7.21 0.37 3.86e-12 Parkinson's disease; CRC cis rs1129187 0.755 rs2274517 chr6:42932715 A/G cg10862848 chr6:42927986 GNMT 0.38 9.19 0.45 4.47e-18 Alzheimer's disease in APOE e4+ carriers; CRC cis rs3859192 0.599 rs34342173 chr17:38161507 T/C cg17467752 chr17:38218738 THRA -0.5 -7.22 -0.37 3.55e-12 White blood cell count; CRC cis rs709400 0.526 rs11622473 chr14:103979762 G/A cg12935359 chr14:103987150 CKB -0.69 -9.09 -0.45 9.79e-18 Body mass index; CRC cis rs875971 0.545 rs221986 chr7:65570310 T/C cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.61 -7.94 -0.4 3.33e-14 Aortic root size; CRC cis rs6502050 0.769 rs9898292 chr17:80100345 A/T cg25804541 chr17:80189381 SLC16A3 -0.31 -5.97 -0.31 6.08e-9 Life satisfaction; CRC cis rs9467773 0.935 rs9461270 chr6:26544110 A/G cg09904177 chr6:26538194 HMGN4 0.85 14.88 0.63 1.17e-38 Intelligence (multi-trait analysis); CRC cis rs1971762 0.545 rs876252 chr12:54071422 A/G cg06632207 chr12:54070931 ATP5G2 0.51 8.87 0.44 4.88e-17 Height; CRC trans rs2727020 0.615 rs4980435 chr11:49591576 G/A cg21153622 chr11:89784906 NA -0.37 -5.98 -0.31 5.92e-9 Coronary artery disease; CRC cis rs12681288 0.676 rs17740799 chr8:1014327 C/T cg08648136 chr8:956695 NA -0.3 -5.64 -0.3 3.72e-8 Schizophrenia; CRC cis rs8014204 0.804 rs35641442 chr14:75207263 G/A cg03030879 chr14:75389066 RPS6KL1 -0.52 -8.31 -0.42 2.56e-15 Caffeine consumption; CRC cis rs62064224 0.589 rs9910731 chr17:30784034 A/G cg18200150 chr17:30822561 MYO1D 0.48 9.59 0.47 2.25e-19 Schizophrenia; CRC cis rs62432291 0.681 rs397476 chr6:159639284 A/G cg14500486 chr6:159655392 FNDC1 -0.7 -9.97 -0.48 1.21e-20 Joint mobility (Beighton score); CRC cis rs12476592 0.602 rs262488 chr2:63882179 C/T cg10828910 chr2:63850056 LOC388955 0.5 6.36 0.33 6.57e-10 Childhood ear infection; CRC trans rs4276421 0.837 rs7446182 chr5:45401817 A/T cg04793272 chr11:119020941 ABCG4 0.38 6.2 0.32 1.69e-9 P wave duration; CRC cis rs4566357 0.615 rs2894626 chr2:227916039 T/C cg11843606 chr2:227700838 RHBDD1 -0.44 -6.85 -0.35 3.65e-11 Coronary artery disease; CRC cis rs561341 1.000 rs693116 chr17:30246124 C/T cg12193833 chr17:30244370 NA -0.73 -8.49 -0.42 7.41e-16 Hip circumference adjusted for BMI; CRC cis rs9393777 0.920 rs13191227 chr6:27390115 G/C cg15845792 chr6:28175446 NA 0.89 5.71 0.3 2.56e-8 Intelligence (multi-trait analysis); CRC cis rs6951245 1.000 rs76804143 chr7:1082021 C/T cg18402987 chr7:1209562 NA 0.64 6.78 0.35 5.48e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs6909279 0.678 rs11155795 chr6:151851339 A/G cg10883421 chr6:151773342 RMND1;C6orf211 0.38 5.88 0.31 1.02e-8 Bone mineral density; CRC cis rs11585357 0.947 rs11584287 chr1:17607501 G/C cg08277548 chr1:17600880 PADI3 -0.91 -11.38 -0.53 1.62e-25 Hair shape; CRC cis rs999943 0.774 rs12205634 chr6:33611667 C/G cg14003231 chr6:33640908 ITPR3 0.98 18.19 0.71 1.16e-51 Obesity (extreme); CRC trans rs12699921 0.632 rs1524776 chr7:17872093 C/A cg02066331 chr6:17282778 RBM24 -0.36 -6.17 -0.32 2.02e-9 Fibrinogen levels; CRC cis rs3733585 0.673 rs4627861 chr4:9954238 T/G cg11266682 chr4:10021025 SLC2A9 -0.47 -9.62 -0.47 1.76e-19 Cleft plate (environmental tobacco smoke interaction); CRC cis rs12458462 0.787 rs56006341 chr18:77439844 G/T cg11879182 chr18:77439856 CTDP1 0.71 11.38 0.53 1.56e-25 Monocyte count; CRC cis rs7586879 0.719 rs7565468 chr2:25130092 C/T cg04586622 chr2:25135609 ADCY3 -0.57 -9.71 -0.47 8.94e-20 Body mass index; CRC cis rs765787 0.530 rs28396110 chr15:45536909 A/G cg24006582 chr15:45444508 DUOX1 -0.57 -8.63 -0.43 2.62e-16 Uric acid levels; CRC trans rs7267979 0.899 rs442834 chr20:25458096 A/G cg17903999 chr18:56338584 MALT1 -0.41 -6.95 -0.36 1.98e-11 Liver enzyme levels (alkaline phosphatase); CRC cis rs6662572 0.737 rs56295206 chr1:46551026 G/A cg08644498 chr1:46502608 NA 0.43 6.61 0.34 1.53e-10 Blood protein levels; CRC trans rs1005277 0.579 rs1780136 chr10:38501453 A/G cg27523141 chr10:43048294 ZNF37B 0.47 6.89 0.36 2.87e-11 Extrinsic epigenetic age acceleration; CRC cis rs9287719 0.935 rs728283 chr2:10750090 C/T cg00105475 chr2:10696890 NA 0.45 7.17 0.37 4.87e-12 Prostate cancer; CRC cis rs6495122 0.501 rs12904227 chr15:75387048 A/C cg17294928 chr15:75287854 SCAMP5 -0.43 -6.48 -0.34 3.29e-10 Caffeine consumption;Diastolic blood pressure;Coffee consumption; CRC cis rs1577917 0.958 rs2197648 chr6:86543887 C/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.49 -6.53 -0.34 2.47e-10 Response to antipsychotic treatment; CRC cis rs611744 0.647 rs1457211 chr8:109261318 C/T cg18478394 chr8:109455254 TTC35 -0.39 -5.96 -0.31 6.62e-9 Dupuytren's disease; CRC cis rs2228479 0.557 rs34420680 chr16:89809171 C/T cg06656553 chr16:89960601 TCF25 -0.72 -5.86 -0.31 1.14e-8 Skin colour saturation; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg21412992 chr1:61547497 NFIA 0.42 6.34 0.33 7.44e-10 Liver disease severity in Alagille syndrome; CRC cis rs72945132 0.714 rs66542029 chr11:70196302 A/T cg00319359 chr11:70116639 PPFIA1 0.56 6.1 0.32 2.9e-9 Coronary artery disease; CRC cis rs4862750 0.872 rs6830426 chr4:187897270 T/A cg03647317 chr4:187891568 NA -0.53 -9.9 -0.48 2.14e-20 Lobe attachment (rater-scored or self-reported); CRC trans rs10982213 0.830 rs2274163 chr9:117188714 C/T cg07050827 chr2:228280252 NA 0.44 6.85 0.35 3.59e-11 Interleukin-6 levels; CRC trans rs2303319 0.582 rs56094729 chr2:162464835 C/T cg03757145 chr4:76555832 CDKL2 -0.66 -5.97 -0.31 5.99e-9 Cognitive function; CRC cis rs7914558 1.000 rs3740387 chr10:104849468 G/A cg04362960 chr10:104952993 NT5C2 0.6 9.09 0.45 9.73e-18 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs7927592 0.913 rs7127948 chr11:68363062 G/A cg01657329 chr11:68192670 LRP5 -0.47 -6.79 -0.35 5.16e-11 Total body bone mineral density; CRC cis rs11098499 0.913 rs10006304 chr4:120124305 A/G cg09307838 chr4:120376055 NA 0.61 9.03 0.45 1.48e-17 Corneal astigmatism; CRC trans rs9929218 1.000 rs2113199 chr16:68814502 A/G cg04657470 chr2:198365150 HSPE1;HSPD1 -0.83 -11.85 -0.55 3.21e-27 Colorectal cancer; CRC cis rs2404602 0.716 rs7174953 chr15:76906847 A/C cg22467129 chr15:76604101 ETFA -0.39 -6.43 -0.33 4.62e-10 Blood metabolite levels; CRC cis rs6582630 0.638 rs35864536 chr12:38472255 T/A cg13010199 chr12:38710504 ALG10B -0.42 -5.98 -0.31 5.84e-9 Drug-induced liver injury (flucloxacillin); CRC cis rs9311474 0.713 rs352166 chr3:52238677 C/T cg08222913 chr3:52553049 STAB1 -0.35 -6.45 -0.34 3.98e-10 Electroencephalogram traits; CRC cis rs801193 0.636 rs2659895 chr7:66196471 C/A cg12463550 chr7:65579703 CRCP 0.45 6.25 0.33 1.26e-9 Aortic root size; CRC trans rs7615952 0.512 rs4234285 chr3:125404477 G/A cg02560186 chr11:3602584 NA -0.63 -9.64 -0.47 1.62e-19 Blood pressure (smoking interaction); CRC cis rs10791097 0.720 rs7119425 chr11:130733185 C/T cg12179176 chr11:130786555 SNX19 0.7 11.09 0.52 1.67e-24 Autism spectrum disorder or schizophrenia;Schizophrenia; CRC cis rs9303280 0.901 rs2952140 chr17:37928059 C/T cg20243544 chr17:37824526 PNMT -0.42 -6.54 -0.34 2.31e-10 Self-reported allergy; CRC cis rs2718798 1 rs2718798 chr3:133492088 A/C cg27366882 chr3:133540807 NA 0.4 5.93 0.31 7.46e-9 Ankle injury; CRC cis rs8077889 0.917 rs72836556 chr17:41911824 G/T cg25876840 chr17:41920477 NA 0.62 8.74 0.43 1.19e-16 Triglycerides; CRC cis rs9486719 1.000 rs12197411 chr6:97039621 G/A cg06623918 chr6:96969491 KIAA0776 -0.81 -9.6 -0.47 2.04e-19 Migraine;Coronary artery disease; CRC cis rs7945705 0.869 rs7925728 chr11:9013002 A/G cg21881798 chr11:8931708 C11orf17;ST5 -0.68 -11.34 -0.53 2.27e-25 Hemoglobin concentration; CRC cis rs9910055 0.502 rs1684662 chr17:42180822 T/A cg13607699 chr17:42295918 UBTF -0.48 -6.38 -0.33 6.17e-10 Total body bone mineral density; CRC trans rs12699921 0.568 rs2691605 chr7:17877448 T/C cg15753394 chr6:17282781 RBM24 -0.36 -6.13 -0.32 2.51e-9 Fibrinogen levels; CRC cis rs250677 0.687 rs168750 chr5:148446756 A/G cg23229984 chr5:148520753 ABLIM3 0.5 6.95 0.36 1.96e-11 Breast cancer; CRC cis rs7296418 0.961 rs7957096 chr12:123544878 A/G cg02203224 chr12:123464087 ARL6IP4;OGFOD2 -0.34 -5.65 -0.3 3.5e-8 Platelet count; CRC cis rs10504229 0.953 rs59265461 chr8:58189701 A/T cg22535103 chr8:58192502 C8orf71 -0.82 -12.27 -0.56 9.63e-29 Developmental language disorder (linguistic errors); CRC cis rs3540 0.533 rs12916560 chr15:91056259 A/C cg22089800 chr15:90895588 ZNF774 -0.58 -9.57 -0.47 2.68e-19 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; CRC cis rs853679 0.760 rs11967137 chr6:28199764 A/G cg02683197 chr6:28174875 NA 0.67 6.91 0.36 2.55e-11 Depression; CRC cis rs477692 0.673 rs579952 chr10:131356084 A/T cg05714579 chr10:131428358 MGMT -0.48 -6.77 -0.35 6.07e-11 Response to temozolomide; CRC cis rs514406 0.584 rs12095247 chr1:53193796 A/C cg08859206 chr1:53392774 SCP2 0.42 6.4 0.33 5.29e-10 Monocyte count; CRC cis rs11148252 0.740 rs9596643 chr13:52912380 G/A cg02158880 chr13:53174818 NA -0.44 -6.38 -0.33 6e-10 Lewy body disease; CRC cis rs10504229 0.593 rs79874994 chr8:57993709 C/A cg24829409 chr8:58192753 C8orf71 -0.53 -6.22 -0.32 1.5e-9 Developmental language disorder (linguistic errors); CRC cis rs10256972 0.567 rs2960835 chr7:1202963 A/G cg23708337 chr7:1209742 NA 0.49 7.52 0.38 5.39e-13 Longevity;Endometriosis; CRC cis rs1322512 0.917 rs2489545 chr6:153006907 C/T cg03415253 chr6:152958462 SYNE1 0.4 6.04 0.32 4.14e-9 Tonometry; CRC trans rs6693295 0.605 rs6692457 chr1:246216326 A/C cg03680032 chr11:94965610 SESN3 0.49 6.12 0.32 2.68e-9 Migraine - clinic-based;Migraine with aura; CRC cis rs7937682 0.632 rs11214015 chr11:111719417 A/T cg19812747 chr11:111475976 SIK2 -0.46 -6.62 -0.34 1.47e-10 Primary sclerosing cholangitis; CRC cis rs6570726 0.846 rs453834 chr6:145886261 T/C cg13319975 chr6:146136371 FBXO30 -0.39 -5.86 -0.31 1.13e-8 Lobe attachment (rater-scored or self-reported); CRC cis rs7814319 0.700 rs11995989 chr8:97264456 C/G cg20787634 chr8:97240163 UQCRB -0.45 -7.22 -0.37 3.54e-12 Lung function (FVC); CRC trans rs7615952 0.512 rs11929125 chr3:125359443 G/A cg21747405 chr11:67723411 NA -0.58 -9.13 -0.45 6.88e-18 Blood pressure (smoking interaction); CRC cis rs11212617 0.967 rs4754305 chr11:108075912 T/C cg12106634 chr11:108092400 ATM;NPAT 0.42 6.22 0.32 1.49e-9 Response to metformin in type 2 diabetes (glycemic); CRC cis rs11148252 0.553 rs7999849 chr13:53249414 A/G cg02158880 chr13:53174818 NA 0.54 8.63 0.43 2.65e-16 Lewy body disease; CRC cis rs6502050 0.835 rs12950475 chr17:80118924 T/C cg13198984 chr17:80129470 CCDC57 0.47 8.35 0.42 1.88e-15 Life satisfaction; CRC cis rs12477438 0.798 rs12473029 chr2:99637961 A/G cg26064155 chr2:99771622 LIPT1;TSGA10 -0.81 -11.61 -0.54 2.3e-26 Chronic sinus infection; CRC trans rs2303319 0.504 rs62188961 chr2:162495399 A/G cg18122310 chr12:50236657 BCDIN3D -0.74 -6.19 -0.32 1.81e-9 Cognitive function; CRC cis rs2404602 0.647 rs1443115 chr15:77041829 T/C cg23625390 chr15:77176239 SCAPER -0.84 -12.98 -0.58 2.2e-31 Blood metabolite levels; CRC cis rs57221529 0.713 rs56328416 chr5:591138 G/A cg14541582 chr5:601475 NA -0.36 -7.2 -0.37 4.08e-12 Lung disease severity in cystic fibrosis; CRC cis rs514406 0.548 rs6670871 chr1:53212082 A/C cg24675658 chr1:53192096 ZYG11B 0.65 10.06 0.49 6.2e-21 Monocyte count; CRC cis rs1799949 0.896 rs8176098 chr17:41268206 A/C cg19454999 chr17:41278357 BRCA1;NBR2 0.55 8.76 0.43 1.07e-16 Menopause (age at onset); CRC trans rs2727020 0.894 rs1917328 chr11:49359606 G/A cg15704280 chr7:45808275 SEPT13 -0.75 -9.91 -0.48 1.93e-20 Coronary artery disease; CRC cis rs11971779 0.584 rs10236055 chr7:139069991 A/G cg23387468 chr7:139079360 LUC7L2 0.41 7.04 0.36 1.14e-11 Diisocyanate-induced asthma; CRC cis rs72781680 0.612 rs33913065 chr2:24344060 T/G cg20701182 chr2:24300061 SF3B14 0.58 7.06 0.36 9.73e-12 Lymphocyte counts; CRC cis rs1552244 0.554 rs2272122 chr3:10047975 C/G cg08888203 chr3:10149979 C3orf24 0.49 7.26 0.37 2.76e-12 Alzheimer's disease; CRC cis rs3741404 0.560 rs12362602 chr11:63908660 G/A cg06219103 chr11:63990595 FERMT3 0.47 7.66 0.39 2.04e-13 Platelet count; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg00185336 chr7:73153699 ABHD11 0.43 6.38 0.33 5.94e-10 Response to antipsychotic treatment; CRC cis rs916888 0.821 rs199509 chr17:44858728 G/A cg15921436 chr17:44337874 NA -0.68 -7.81 -0.4 7.78e-14 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg12741539 chr12:42719903 PPHLN1;ZCRB1 0.45 6.52 0.34 2.64e-10 Intelligence (multi-trait analysis); CRC cis rs6754311 0.678 rs309181 chr2:136614813 C/G cg15123519 chr2:136567270 LCT 0.34 6.57 0.34 1.94e-10 Mosquito bite size; CRC trans rs1005277 0.579 rs2474588 chr10:38420870 A/G cg11292332 chr7:45801988 SEPT13 -0.35 -6.3 -0.33 9.49e-10 Extrinsic epigenetic age acceleration; CRC cis rs533581 0.866 rs865102 chr16:88969969 A/G cg16701003 chr16:89028210 CBFA2T3 0.43 6.96 0.36 1.88e-11 Social autistic-like traits; CRC cis rs2836974 0.965 rs8134733 chr21:40683459 C/T cg17971929 chr21:40555470 PSMG1 0.8 11.11 0.52 1.4e-24 Cognitive function; CRC cis rs10504229 0.683 rs11784908 chr8:58131472 T/C cg02290350 chr8:58132656 NA -0.58 -8.16 -0.41 7.29e-15 Developmental language disorder (linguistic errors); CRC trans rs12599106 0.792 rs11648801 chr16:34360980 C/T cg07332563 chr6:291687 DUSP22 -0.5 -7.05 -0.36 1.03e-11 Menopause (age at onset); CRC cis rs6540559 0.673 rs6540561 chr1:209982255 C/T cg22029157 chr1:209979665 IRF6 0.72 9.54 0.47 3.38e-19 Cleft lip with or without cleft palate; CRC cis rs6570726 0.935 rs369214 chr6:145856709 G/A cg05347473 chr6:146136440 FBXO30 0.38 6.1 0.32 2.92e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs1218582 0.741 rs883718 chr1:154846274 C/T cg03351412 chr1:154909251 PMVK 0.53 8.45 0.42 9.33e-16 Prostate cancer; CRC cis rs909002 1.000 rs1474182 chr1:32136398 C/T cg01639898 chr1:32083012 HCRTR1 0.29 5.78 0.3 1.72e-8 Intelligence (multi-trait analysis); CRC cis rs282587 0.502 rs416703 chr13:113399219 A/G cg04656015 chr13:113407548 ATP11A 0.62 7.97 0.4 2.63e-14 Glycated hemoglobin levels; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg08474403 chr1:68962753 DEPDC1 0.45 6.05 0.32 4.05e-9 Anxiety disorder; CRC cis rs597539 0.652 rs513359 chr11:68669496 A/T cg11716795 chr11:68671300 MRPL21;IGHMBP2 -0.89 -15.51 -0.65 4.12e-41 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs4713118 0.539 rs200967 chr6:27862127 A/G cg26587870 chr6:27730563 NA -0.44 -6.64 -0.34 1.32e-10 Parkinson's disease; CRC cis rs6748734 1.000 rs4675874 chr2:241819796 A/G cg04034577 chr2:241836375 C2orf54 0.42 8.81 0.44 7.16e-17 Urinary metabolites; CRC cis rs853679 0.517 rs9295761 chr6:28147987 A/G cg03623178 chr6:28175578 NA 0.99 12.74 0.57 1.71e-30 Depression; CRC cis rs12422267 0.609 rs10128884 chr12:132621624 C/T cg09764611 chr12:132620959 NA -0.57 -7.96 -0.4 2.73e-14 Plasma amyloid beta peptide concentrations (ABx-40); CRC cis rs8067545 0.685 rs4479309 chr17:19971583 C/T cg13482628 chr17:19912719 NA 0.51 7.97 0.4 2.59e-14 Schizophrenia; CRC cis rs7666738 0.791 rs62318641 chr4:98816964 T/C cg17366294 chr4:99064904 C4orf37 0.43 6.86 0.35 3.35e-11 Colonoscopy-negative controls vs population controls; CRC trans rs9926296 0.585 rs6500441 chr16:89828669 C/G ch.11.1155333R chr11:60687684 TMEM109 -0.43 -6.1 -0.32 3.04e-9 Vitiligo; CRC cis rs72945132 1.000 rs72945132 chr11:70113901 G/C cg00319359 chr11:70116639 PPFIA1 0.65 6.19 0.32 1.76e-9 Coronary artery disease; CRC cis rs1814175 0.527 rs3974435 chr11:49619533 G/A cg25886479 chr11:50257625 LOC441601 -0.33 -5.64 -0.3 3.65e-8 Height; CRC cis rs6495122 0.501 rs8039755 chr15:75337426 T/C cg14664628 chr15:75095509 CSK 0.47 6.81 0.35 4.59e-11 Caffeine consumption;Diastolic blood pressure;Coffee consumption; CRC cis rs2046867 0.818 rs62249866 chr3:72878632 T/C cg25664220 chr3:72788482 NA -0.46 -6.47 -0.34 3.62e-10 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; CRC cis rs7618915 0.571 rs33964154 chr3:52596914 A/G cg18099408 chr3:52552593 STAB1 -0.44 -7.36 -0.38 1.52e-12 Bipolar disorder; CRC cis rs7707921 0.705 rs226194 chr5:81585026 G/T cg07807695 chr5:81608485 ATP6AP1L -0.48 -7.59 -0.39 3.39e-13 Breast cancer; CRC cis rs66782572 1 rs66782572 chr3:52567617 A/G cg15147215 chr3:52552868 STAB1 -0.74 -14.83 -0.63 1.81e-38 Hemoglobin concentration; CRC cis rs1519814 1.000 rs10104973 chr8:121104385 C/T cg22335954 chr8:121166405 COL14A1 -0.5 -6.25 -0.33 1.24e-9 Breast cancer; CRC cis rs10504229 1.000 rs66886949 chr8:58187613 A/G cg01721255 chr8:58191610 C8orf71 0.49 6.17 0.32 2e-9 Developmental language disorder (linguistic errors); CRC cis rs483180 0.512 rs1163251 chr1:120209755 T/C cg19096424 chr1:120255104 PHGDH -0.44 -6.42 -0.33 4.64e-10 Macular telangiectasia type 2; CRC cis rs7072216 0.922 rs2296438 chr10:100146895 T/C cg26618903 chr10:100175079 PYROXD2 -0.35 -5.97 -0.31 6.2e-9 Metabolite levels; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg22146484 chr8:57123862 CHCHD7;PLAG1 0.46 6.76 0.35 6.11e-11 Response to antipsychotic treatment; CRC cis rs12048904 0.619 rs12239082 chr1:101330077 G/T cg16556008 chr1:101360663 SLC30A7;EXTL2 -0.91 -14.96 -0.64 5.92e-39 Multiple sclerosis; CRC cis rs870825 0.581 rs7675106 chr4:185652388 C/G cg07424746 chr4:185654737 MLF1IP 0.51 5.69 0.3 2.8e-8 Blood protein levels; CRC cis rs9902453 0.904 rs4547389 chr17:28364768 T/C cg26525008 chr17:28256777 EFCAB5;SSH2 -0.69 -11.35 -0.53 2.01e-25 Coffee consumption (cups per day); CRC cis rs9649213 0.593 rs2107716 chr7:97944744 G/A cg24562669 chr7:97807699 LMTK2 0.43 7.17 0.37 4.87e-12 Prostate cancer (SNP x SNP interaction); CRC cis rs12148488 0.966 rs1867148 chr15:75339985 T/C cg14664628 chr15:75095509 CSK 0.47 6.81 0.35 4.59e-11 Caffeine consumption; CRC cis rs7178572 0.568 rs7175674 chr15:77670910 C/T cg22256960 chr15:77711686 NA -0.64 -9.24 -0.45 3.07e-18 Type 2 diabetes; CRC cis rs7208859 0.623 rs55961983 chr17:29119286 G/A cg01831904 chr17:28903510 LRRC37B2 -0.63 -6.49 -0.34 3.2e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs6479527 0.840 rs1832857 chr9:96751679 T/C cg14459158 chr9:96720562 NA 0.41 7.52 0.38 5.11e-13 Esophageal adenocarcinoma; CRC cis rs2836633 0.894 rs55955614 chr21:40037330 T/G cg12884169 chr21:40033163 ERG 0.43 10.05 0.48 6.76e-21 Coronary artery disease; CRC trans rs877282 0.853 rs12763400 chr10:763617 C/T cg22713356 chr15:30763199 NA 1.28 15.26 0.64 3.9e-40 Uric acid levels; CRC cis rs11155671 0.530 rs3823021 chr6:150210999 G/C cg13206674 chr6:150067644 NUP43 0.49 7.04 0.36 1.13e-11 Testicular germ cell tumor; CRC cis rs1552244 0.554 rs6762397 chr3:10007840 C/T cg02579736 chr3:10068473 FANCD2;CIDECP 0.63 8.76 0.43 1.08e-16 Alzheimer's disease; CRC cis rs2276314 0.857 rs6507157 chr18:33631703 A/C cg05985134 chr18:33552581 C18orf21 0.5 6.67 0.35 1.09e-10 Endometriosis;Drug-induced torsades de pointes; CRC cis rs10504229 0.728 rs17215851 chr8:58154160 A/C cg05313129 chr8:58192883 C8orf71 -0.47 -6.18 -0.32 1.94e-9 Developmental language disorder (linguistic errors); CRC cis rs9611565 0.512 rs5758439 chr22:42131762 C/T cg03806693 chr22:41940476 POLR3H 1.08 13.41 0.59 5.35e-33 Vitiligo; CRC cis rs6582630 0.502 rs11495393 chr12:38341194 T/C cg26384229 chr12:38710491 ALG10B 0.68 9.66 0.47 1.31e-19 Drug-induced liver injury (flucloxacillin); CRC cis rs372883 0.648 rs1153288 chr21:30686091 A/G cg08807101 chr21:30365312 RNF160 0.5 6.84 0.35 3.81e-11 Pancreatic cancer; CRC cis rs7072216 0.763 rs6584205 chr10:100173806 C/T cg26618903 chr10:100175079 PYROXD2 -0.55 -8.99 -0.44 2.03e-17 Metabolite levels; CRC cis rs1336900 0.513 rs56253522 chr1:150614869 C/A cg18016565 chr1:150552671 MCL1 0.49 7.05 0.36 1.04e-11 Blood protein levels; CRC cis rs2455601 0.786 rs3763913 chr11:8951230 C/T cg21881798 chr11:8931708 C11orf17;ST5 -0.55 -6.31 -0.33 9.09e-10 Schizophrenia; CRC cis rs7584330 0.868 rs13386290 chr2:238393136 G/C cg11271282 chr2:238384023 NA 0.47 6.06 0.32 3.78e-9 Prostate cancer; CRC cis rs2295359 1.000 rs12043240 chr1:67624304 C/T cg03340356 chr1:67600835 NA 0.25 5.72 0.3 2.34e-8 Psoriasis; CRC cis rs11168351 0.864 rs12228750 chr12:48496997 G/A cg21466736 chr12:48725269 NA 0.47 7.26 0.37 2.77e-12 Bipolar disorder and schizophrenia; CRC cis rs1865760 0.566 rs9379821 chr6:26054268 A/C cg16482183 chr6:26056742 HIST1H1C 0.52 7.55 0.38 4.44e-13 Height; CRC cis rs6908034 0.607 rs112599867 chr6:19805532 A/G cg02682789 chr6:19804855 NA 0.8 6.74 0.35 6.9e-11 Endometriosis;Deep ovarian and/or rectovaginal disease with dense adhesions; CRC cis rs34779708 0.931 rs11010125 chr10:35502953 A/G cg03585969 chr10:35415529 CREM 0.55 7.4 0.38 1.17e-12 Inflammatory bowel disease;Crohn's disease; CRC cis rs561341 0.883 rs7219239 chr17:30212016 A/G cg13647721 chr17:30228624 UTP6 -0.56 -5.68 -0.3 3.04e-8 Hip circumference adjusted for BMI; CRC cis rs4665809 1.000 rs4233710 chr2:26291565 G/A cg25036284 chr2:26402008 FAM59B -0.46 -5.72 -0.3 2.38e-8 Gut microbiome composition (summer); CRC trans rs2727020 0.567 rs1164687 chr11:49290669 G/A cg15704280 chr7:45808275 SEPT13 0.72 10.13 0.49 3.57e-21 Coronary artery disease; CRC trans rs17742757 0.521 rs2736324 chr8:11328182 C/G cg06636001 chr8:8085503 FLJ10661 0.47 6.79 0.35 5.25e-11 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg09773150 chr17:3796596 CAMKK1 -0.42 -6.18 -0.32 1.84e-9 Myopia (pathological); CRC cis rs7119 0.717 rs12902896 chr15:77809150 G/T cg27398640 chr15:77910606 LINGO1 0.43 7.59 0.39 3.27e-13 Type 2 diabetes; CRC cis rs13253111 0.624 rs13277389 chr8:28100234 G/T cg26534493 chr8:28060551 NA 0.42 7.15 0.37 5.7e-12 Childhood body mass index; CRC cis rs34779708 0.931 rs35126129 chr10:35452141 G/A cg03585969 chr10:35415529 CREM 0.63 8.39 0.42 1.42e-15 Inflammatory bowel disease;Crohn's disease; CRC cis rs1448094 0.511 rs61930590 chr12:86159959 T/A cg02569458 chr12:86230093 RASSF9 0.47 7.83 0.4 6.84e-14 Major depressive disorder; CRC cis rs9911578 0.967 rs302843 chr17:56727986 C/T cg05425664 chr17:57184151 TRIM37 -0.5 -7.94 -0.4 3.16e-14 Intelligence (multi-trait analysis); CRC cis rs6499255 1.000 rs73579497 chr16:69824150 C/G cg00738113 chr16:70207722 CLEC18C -0.4 -5.78 -0.3 1.72e-8 IgE levels; CRC cis rs4363385 0.818 rs1750309 chr1:153013630 G/C cg25856811 chr1:152973957 SPRR3 -0.27 -7.49 -0.38 6.23e-13 Inflammatory skin disease; CRC cis rs35264875 0.898 rs56140802 chr11:68861631 G/A cg15234197 chr11:68924956 NA 0.42 5.8 0.3 1.57e-8 Blond vs. brown hair color; CRC cis rs13082711 0.595 rs1445114 chr3:27345489 C/A cg02860705 chr3:27208620 NA 0.81 10.48 0.5 2.25e-22 Systolic blood pressure;Diastolic blood pressure;Blood pressure; CRC cis rs7781266 0.790 rs11766325 chr7:133123616 A/C cg03336402 chr7:133662267 EXOC4 0.49 5.81 0.31 1.47e-8 Educational attainment (college completion); CRC cis rs995000 0.931 rs6690733 chr1:63060311 A/C cg19896129 chr1:63156450 NA 0.42 6.45 0.34 3.95e-10 Triglyceride levels; CRC cis rs2408955 0.522 rs3997 chr12:48481587 T/C cg24011408 chr12:48396354 COL2A1 -0.45 -6.41 -0.33 5.04e-10 Glycated hemoglobin levels; CRC cis rs6952808 0.760 rs34961072 chr7:1948620 G/C cg21782813 chr7:2030301 MAD1L1 0.44 7.15 0.37 5.56e-12 Bipolar disorder and schizophrenia; CRC cis rs2842992 0.830 rs2758313 chr6:160154099 C/G cg19482086 chr6:160211437 TCP1;MRPL18 0.73 9.36 0.46 1.33e-18 Age-related macular degeneration (geographic atrophy); CRC cis rs10464366 0.544 rs953874 chr7:39147916 G/A cg15212455 chr7:39170539 POU6F2 0.47 6.32 0.33 8.68e-10 IgG glycosylation; CRC cis rs727505 0.954 rs1525613 chr7:124658636 A/G cg23710748 chr7:124431027 NA -0.81 -14.1 -0.61 1.26e-35 Lewy body disease; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg03425468 chr1:155164676 MIR92B 0.45 7.2 0.37 4.21e-12 Liver disease severity in Alagille syndrome; CRC cis rs4332037 0.851 rs10268609 chr7:1962163 A/C cg25834613 chr7:1915315 MAD1L1 -0.44 -6.49 -0.34 3.21e-10 Bipolar disorder; CRC cis rs908922 0.676 rs568661 chr1:152519787 C/A cg09873164 chr1:152488093 CRCT1 0.37 6.29 0.33 1e-9 Hair morphology; CRC cis rs1865760 0.566 rs1539183 chr6:26075051 G/C cg16482183 chr6:26056742 HIST1H1C 0.52 7.57 0.39 3.69e-13 Height; CRC trans rs7395662 1.000 rs11039857 chr11:48610853 T/C cg21153622 chr11:89784906 NA -0.48 -7.68 -0.39 1.78e-13 HDL cholesterol; CRC cis rs7618915 0.571 rs67539070 chr3:52711974 T/C cg15147215 chr3:52552868 STAB1 -0.63 -10.4 -0.5 4.44e-22 Bipolar disorder; CRC cis rs9420 0.961 rs11229148 chr11:57621460 A/T cg23127183 chr11:57508653 C11orf31 -0.53 -7.06 -0.36 1.02e-11 Schizophrenia; CRC cis rs240764 0.578 rs12215909 chr6:101227598 T/C cg09795085 chr6:101329169 ASCC3 -0.41 -5.66 -0.3 3.23e-8 Neuroticism; CRC cis rs11212617 0.967 rs605394 chr11:108243628 C/T cg01991180 chr11:108092276 ATM;NPAT -0.42 -5.99 -0.31 5.43e-9 Response to metformin in type 2 diabetes (glycemic); CRC cis rs17152411 1.000 rs41303609 chr10:126670613 G/T cg07906193 chr10:126599966 NA 0.63 6.82 0.35 4.46e-11 Height; CRC cis rs2976388 0.609 rs2585152 chr8:143786214 A/T cg05569086 chr8:143859399 LYNX1 0.4 6.91 0.36 2.57e-11 Urinary tract infection frequency; CRC cis rs9463078 0.691 rs12209727 chr6:45353100 C/T cg25276700 chr6:44698697 NA 0.26 6.2 0.32 1.68e-9 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; CRC cis rs10504229 0.728 rs72650868 chr8:58155568 G/C cg05313129 chr8:58192883 C8orf71 -0.47 -6.18 -0.32 1.94e-9 Developmental language disorder (linguistic errors); CRC cis rs12024301 0.557 rs6424898 chr1:183596045 G/A cg11505048 chr1:183622726 RGL1;APOBEC4 0.76 6.93 0.36 2.16e-11 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs1577917 0.958 rs12198061 chr6:86550985 T/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.51 -6.67 -0.35 1.07e-10 Response to antipsychotic treatment; CRC cis rs875971 0.522 rs709604 chr7:65497434 A/G cg02869306 chr7:64672164 INTS4L1 0.34 5.62 0.3 4.15e-8 Aortic root size; CRC cis rs561341 0.609 rs2051810 chr17:30195841 C/T cg12193833 chr17:30244370 NA 0.45 5.97 0.31 6e-9 Hip circumference adjusted for BMI; CRC cis rs4713118 0.869 rs9283880 chr6:27715243 A/C cg08798685 chr6:27730294 NA -0.42 -6.22 -0.32 1.51e-9 Parkinson's disease; CRC cis rs477692 0.789 rs507900 chr10:131398144 A/G cg05714579 chr10:131428358 MGMT -0.5 -7.22 -0.37 3.54e-12 Response to temozolomide; CRC cis rs2204008 0.837 rs11181857 chr12:38413255 C/G cg13010199 chr12:38710504 ALG10B 0.46 6.2 0.32 1.73e-9 Bladder cancer; CRC cis rs1691799 0.899 rs1168301 chr12:66736771 C/T cg16791601 chr12:66731901 HELB -0.68 -11.49 -0.54 6.43e-26 White blood cell count (basophil); CRC cis rs7927592 0.673 rs498782 chr11:68275851 A/G cg16797656 chr11:68205561 LRP5 0.49 8.99 0.44 2e-17 Total body bone mineral density; CRC cis rs6502050 0.871 rs11870632 chr17:80075406 T/C cg11859384 chr17:80120422 CCDC57 0.37 5.82 0.31 1.43e-8 Life satisfaction; CRC trans rs10982213 0.830 rs2274163 chr9:117188714 C/T cg15704304 chr12:68881427 NA -0.4 -6.33 -0.33 7.97e-10 Interleukin-6 levels; CRC cis rs35883536 0.626 rs12135243 chr1:101092955 G/A cg14515779 chr1:101123966 NA 0.35 5.84 0.31 1.25e-8 Monocyte count; CRC cis rs9487051 0.837 rs4403290 chr6:109611583 A/T cg12927641 chr6:109611667 NA -0.37 -6.72 -0.35 8.01e-11 Reticulocyte fraction of red cells; CRC cis rs524281 0.731 rs11227433 chr11:66004693 G/A cg16950941 chr11:66035639 RAB1B -0.7 -8.04 -0.41 1.67e-14 Electroencephalogram traits; CRC cis rs1949733 0.656 rs6845969 chr4:8402465 A/T cg11789530 chr4:8429930 ACOX3 0.72 10.71 0.51 3.72e-23 Response to antineoplastic agents; CRC cis rs7584330 0.554 rs113271883 chr2:238425594 A/G cg14458575 chr2:238380390 NA 0.46 6.61 0.34 1.6e-10 Prostate cancer; CRC cis rs57221529 0.766 rs58015612 chr5:580665 A/T cg16447950 chr5:562315 NA -0.83 -10.78 -0.51 2.14e-23 Lung disease severity in cystic fibrosis; CRC cis rs589448 0.902 rs642786 chr12:69758462 T/C cg14784868 chr12:69753453 YEATS4 0.91 17.67 0.7 1.31e-49 Cerebrospinal fluid biomarker levels; CRC cis rs965469 1.000 rs1040727 chr20:3264292 G/A cg25506879 chr20:3388711 C20orf194 -0.4 -5.7 -0.3 2.71e-8 IFN-related cytopenia; CRC cis rs9462027 0.630 rs7341267 chr6:34727031 A/G cg07306190 chr6:34760872 UHRF1BP1 -0.35 -6.24 -0.33 1.36e-9 Systemic lupus erythematosus; CRC cis rs10540 1.000 rs12801148 chr11:511707 T/G cg21784768 chr11:537496 LRRC56 -0.7 -6.6 -0.34 1.65e-10 Body mass index; CRC cis rs71403859 0.614 rs12447033 chr16:71583655 G/T cg08717414 chr16:71523259 ZNF19 -0.95 -10.04 -0.48 7.06e-21 Post bronchodilator FEV1; CRC trans rs11098499 0.909 rs28714195 chr4:120316950 A/T cg25214090 chr10:38739885 LOC399744 0.65 10.23 0.49 1.69e-21 Corneal astigmatism; CRC cis rs5167 0.504 rs4803779 chr19:45456497 T/C cg13119609 chr19:45449297 APOC2 0.31 5.81 0.3 1.5e-8 Blood protein levels; CRC cis rs9488822 0.636 rs6937104 chr6:116375302 A/G cg26893134 chr6:116381904 FRK 0.28 8.0 0.4 2.15e-14 Cholesterol, total;LDL cholesterol; CRC cis rs6712932 1.000 rs6746579 chr2:105843223 G/T cg27422857 chr2:105853526 NA -0.34 -6.4 -0.33 5.46e-10 Type 2 diabetes; CRC trans rs11039798 0.620 rs10838833 chr11:48238880 C/T cg03929089 chr4:120376271 NA 0.71 6.93 0.36 2.26e-11 Axial length; CRC cis rs7618915 0.501 rs62253740 chr3:52684128 A/T cg11645453 chr3:52864694 ITIH4 0.37 6.63 0.34 1.38e-10 Bipolar disorder; CRC cis rs11958404 0.860 rs72816577 chr5:157431806 A/G cg05962755 chr5:157440814 NA 1.01 12.88 0.58 5.12e-31 IgG glycosylation; CRC cis rs2842992 0.830 rs1998365 chr6:160179535 A/T cg11366901 chr6:160182831 ACAT2 0.95 13.99 0.61 3.34e-35 Age-related macular degeneration (geographic atrophy); CRC cis rs798554 0.660 rs1182196 chr7:2866478 T/G cg17321639 chr7:2759063 NA -0.43 -6.46 -0.34 3.72e-10 Height; CRC cis rs11971779 0.680 rs10229358 chr7:139052545 C/T cg07862535 chr7:139043722 LUC7L2 -0.57 -7.34 -0.38 1.66e-12 Diisocyanate-induced asthma; CRC cis rs1707322 0.752 rs28890893 chr1:46186576 T/G cg03146154 chr1:46216737 IPP 0.68 9.85 0.48 3.13e-20 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs7811142 1.000 rs76913697 chr7:100002772 A/G cg00814883 chr7:100076585 TSC22D4 -0.73 -9.24 -0.45 3.04e-18 Platelet count; CRC cis rs9807989 0.811 rs4485585 chr2:102970759 T/C cg03938978 chr2:103052716 IL18RAP 0.37 5.97 0.31 6.2e-9 Asthma; CRC cis rs2404602 0.647 rs116505114 chr15:77074794 T/C cg03037974 chr15:76606532 NA -0.57 -8.66 -0.43 2.09e-16 Blood metabolite levels; CRC cis rs1448094 0.512 rs11503595 chr12:86244075 T/A cg00310523 chr12:86230176 RASSF9 0.33 5.62 0.3 3.97e-8 Major depressive disorder; CRC cis rs9611565 0.659 rs17367849 chr22:41923644 G/A cg17554472 chr22:41940697 POLR3H -0.56 -5.89 -0.31 9.48e-9 Vitiligo; CRC cis rs3018066 0.806 rs4314353 chr4:107028003 A/G cg01869342 chr4:106983673 TBCK 0.36 5.67 0.3 3.17e-8 Cancer; CRC cis rs3126085 0.877 rs7535536 chr1:152193544 A/G cg09127314 chr1:152161683 NA 0.52 6.81 0.35 4.79e-11 Atopic dermatitis; CRC cis rs6540559 0.673 rs11805830 chr1:209984969 C/T cg23283495 chr1:209979779 IRF6 0.46 6.63 0.34 1.4e-10 Cleft lip with or without cleft palate; CRC cis rs6585424 1.000 rs61860045 chr10:81947397 C/T cg11900509 chr10:81946545 ANXA11 -0.76 -9.15 -0.45 6.21e-18 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs17095355 1.000 rs72828232 chr10:111725298 C/T cg00817464 chr10:111662876 XPNPEP1 -0.59 -7.12 -0.37 6.81e-12 Biliary atresia; CRC cis rs1008375 0.931 rs6813374 chr4:17649494 T/C cg16339924 chr4:17578868 LAP3 0.55 7.28 0.37 2.41e-12 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs4589502 1.000 rs80263963 chr15:67127228 C/T cg12317470 chr15:67143691 NA 0.75 6.13 0.32 2.45e-9 Lung cancer (smoking interaction); CRC trans rs12439619 1.000 rs12439619 chr15:82546946 T/G cg04831495 chr15:85060580 GOLGA6L5 -0.48 -6.94 -0.36 2.11e-11 Intelligence (multi-trait analysis); CRC cis rs10911232 0.507 rs10797833 chr1:183044067 C/T ch.1.3577855R chr1:183094577 LAMC1 0.8 13.49 0.6 2.68e-33 Hypertriglyceridemia; CRC cis rs7666738 0.830 rs6532721 chr4:99048015 G/A cg05340658 chr4:99064831 C4orf37 0.6 9.35 0.46 1.4e-18 Colonoscopy-negative controls vs population controls; CRC cis rs8141797 0.642 rs1004058 chr22:24482500 A/C cg20894457 chr22:24584366 SUSD2 -0.61 -6.01 -0.31 4.95e-9 Amyotrophic lateral sclerosis;Coronary artery disease; CRC cis rs7618915 0.501 rs2289247 chr3:52727257 C/T cg15147215 chr3:52552868 STAB1 -0.64 -10.92 -0.52 6.97e-24 Bipolar disorder; CRC cis rs6461049 0.638 rs1859993 chr7:2183702 A/G cg08027265 chr7:2291960 NA -0.33 -5.72 -0.3 2.34e-8 Schizophrenia; CRC cis rs7959452 0.562 rs10878975 chr12:69782044 G/C cg22834771 chr12:69754056 YEATS4 -0.54 -8.1 -0.41 1.07e-14 Blood protein levels; CRC cis rs3806843 1.000 rs3756339 chr5:140180537 A/G cg16607685 chr5:140181889 PCDHA2;PCDHA1;PCDHA3 -0.26 -5.97 -0.31 6.03e-9 Depressive symptoms (multi-trait analysis); CRC cis rs11212617 0.805 rs10890821 chr11:108022061 A/T cg12106634 chr11:108092400 ATM;NPAT 0.45 6.73 0.35 7.5e-11 Response to metformin in type 2 diabetes (glycemic); CRC cis rs1707322 1.000 rs4460583 chr1:46449918 C/G cg06784218 chr1:46089804 CCDC17 0.51 8.96 0.44 2.39e-17 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg19963142 chr11:58345608 ZFP91;LPXN;ZFP91-CNTF 0.39 6.04 0.32 4.27e-9 Liver disease severity in Alagille syndrome; CRC cis rs17376456 0.825 rs17374166 chr5:93238655 T/C cg09848695 chr5:92956644 FAM172A;MIR2277 0.66 5.86 0.31 1.13e-8 Diabetic retinopathy; CRC cis rs1670533 1.000 rs11731320 chr4:1057916 T/A cg27284194 chr4:1044797 NA 0.5 6.2 0.32 1.66e-9 Recombination rate (females); CRC cis rs2204008 0.537 rs11170128 chr12:38006632 G/A cg26384229 chr12:38710491 ALG10B 0.67 8.91 0.44 3.49e-17 Bladder cancer; CRC cis rs3749237 0.595 rs4955412 chr3:49418168 A/C cg02487422 chr3:49467188 NICN1 0.42 6.89 0.35 2.9100000000000002e-11 Resting heart rate; CRC cis rs780096 0.546 rs2911712 chr2:27626945 A/T cg21248554 chr2:27665150 KRTCAP3 -0.32 -7.35 -0.38 1.59e-12 Total body bone mineral density; CRC cis rs2067615 0.524 rs10778505 chr12:107143126 G/C cg13491945 chr12:107078410 RFX4 0.34 5.85 0.31 1.19e-8 Heart rate; CRC cis rs60871478 0.947 rs4074610 chr7:791755 G/A cg13844804 chr7:814759 HEATR2 0.62 7.98 0.4 2.51e-14 Cerebrospinal P-tau181p levels; CRC cis rs4713118 0.516 rs6931858 chr6:28078411 A/T cg15845792 chr6:28175446 NA 0.94 11.95 0.55 1.4e-27 Parkinson's disease; CRC cis rs11098499 0.820 rs6534140 chr4:120455311 C/T cg24375607 chr4:120327624 NA 0.47 7.05 0.36 1.06e-11 Corneal astigmatism; CRC cis rs4862750 0.832 rs6419953 chr4:187900509 T/A cg27532560 chr4:187881888 NA -0.57 -10.58 -0.5 1.04e-22 Lobe attachment (rater-scored or self-reported); CRC cis rs644799 0.526 rs506180 chr11:95623109 G/A cg25622487 chr11:95524042 FAM76B;CEP57 0.51 7.56 0.38 4.1e-13 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs9768139 0.708 rs896782 chr7:158114115 G/A cg25566285 chr7:158114605 PTPRN2 0.52 8.58 0.43 3.77e-16 Calcium levels; CRC cis rs2408955 0.500 rs12816820 chr12:48558325 A/G cg00601486 chr12:48723148 H1FNT 0.35 6.77 0.35 6.03e-11 Glycated hemoglobin levels; CRC cis rs3733585 0.699 rs7437120 chr4:9967683 T/A cg00071950 chr4:10020882 SLC2A9 -0.55 -9.85 -0.48 3.13e-20 Cleft plate (environmental tobacco smoke interaction); CRC cis rs950169 0.649 rs12911612 chr15:84691014 T/C cg17507749 chr15:85114479 UBE2QP1 0.66 8.77 0.44 9.86e-17 Schizophrenia; CRC cis rs9611565 0.512 rs1983576 chr22:42166486 G/A cg06634786 chr22:41940651 POLR3H 0.66 7.3 0.37 2.18e-12 Vitiligo; CRC cis rs68170813 0.559 rs2894459 chr7:106960166 C/T cg02696742 chr7:106810147 HBP1 -0.58 -6.39 -0.33 5.58e-10 Coronary artery disease; CRC cis rs853679 0.517 rs1947862 chr6:28105196 C/T cg21251018 chr6:28226885 NKAPL 0.48 6.28 0.33 1.04e-9 Depression; CRC cis rs9311474 0.629 rs11709284 chr3:52559705 G/A cg07507251 chr3:52567010 NT5DC2 0.51 8.05 0.41 1.56e-14 Electroencephalogram traits; CRC cis rs2652834 1.000 rs7182618 chr15:63398622 T/C cg05507819 chr15:63340323 TPM1 0.46 5.87 0.31 1.05e-8 HDL cholesterol; CRC cis rs1451375 1.000 rs10247443 chr7:50620586 G/A cg14593290 chr7:50529359 DDC 0.57 7.88 0.4 4.85e-14 Malaria; CRC cis rs8072100 0.688 rs7221224 chr17:45419061 T/G cg25173405 chr17:45401733 C17orf57 0.42 6.19 0.32 1.77e-9 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs8077889 0.956 rs4792910 chr17:41840229 T/C cg26893861 chr17:41843967 DUSP3 0.99 12.98 0.58 2.16e-31 Triglycerides; CRC trans rs10983614 1.000 rs7867776 chr9:120072627 A/G cg25116269 chr2:55509523 PRDXDD1P 0.46 6.45 0.34 3.89e-10 Survival in pancreatic cancer; CRC cis rs11190604 1.000 rs17746014 chr10:102315354 T/C cg16342193 chr10:102329863 NA -0.36 -5.9 -0.31 9.08e-9 Palmitoleic acid (16:1n-7) levels; CRC cis rs1878931 0.520 rs2015640 chr16:3465018 G/C cg02880119 chr16:3481970 NA 0.49 6.75 0.35 6.85e-11 Body mass index (adult); CRC cis rs10089 1.000 rs1864922 chr5:127420700 T/C cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.71 9.87 0.48 2.78e-20 Ileal carcinoids; CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg15731816 chr14:75230414 YLPM1 -0.51 -6.2 -0.32 1.67e-9 Diisocyanate-induced asthma; CRC cis rs6694672 1.000 rs6656858 chr1:197113573 C/T cg13682187 chr1:196946512 CFHR5 0.45 7.21 0.37 3.89e-12 Asthma; CRC cis rs12681288 0.823 rs2701907 chr8:1003292 A/G cg15309053 chr8:964076 NA 0.34 6.03 0.32 4.45e-9 Schizophrenia; CRC cis rs9868809 0.505 rs28793701 chr3:48762683 C/G cg07636037 chr3:49044803 WDR6 -0.71 -6.59 -0.34 1.72e-10 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; CRC cis rs6500395 1.000 rs9933314 chr16:48676608 T/C cg04672837 chr16:48644449 N4BP1 0.45 6.67 0.35 1.09e-10 Response to tocilizumab in rheumatoid arthritis; CRC cis rs13108904 0.870 rs2291199 chr4:1244267 A/G cg02018176 chr4:1364513 KIAA1530 0.43 7.15 0.37 5.54e-12 Obesity-related traits; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg14978304 chr1:162039761 NOS1AP 0.47 6.57 0.34 1.92e-10 Anxiety disorder; CRC cis rs2721195 0.967 rs748193 chr8:145682115 C/T cg17328964 chr8:145687451 CYHR1 -0.74 -13.59 -0.6 1.06e-33 Age at first birth; CRC cis rs4819052 0.851 rs2838826 chr21:46655785 A/G cg19498844 chr21:46707878 POFUT2;LOC642852 0.74 10.22 0.49 1.73e-21 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs7662987 0.540 rs2851257 chr4:100039499 G/C cg12011299 chr4:100065546 ADH4 0.49 9.26 0.45 2.63e-18 Smoking initiation; CRC cis rs4972806 0.776 rs2072589 chr2:177042871 C/T cg10305451 chr2:177043427 NA 0.7 11.19 0.53 7.42e-25 IgG glycosylation; CRC cis rs611744 0.669 rs13251024 chr8:109258333 T/C cg18478394 chr8:109455254 TTC35 0.37 5.78 0.3 1.75e-8 Dupuytren's disease; CRC cis rs3091242 0.933 rs4649084 chr1:25752617 A/G cg27572855 chr1:25598939 RHD 0.36 6.25 0.33 1.29e-9 Erythrocyte sedimentation rate; CRC cis rs9549260 0.755 rs7985364 chr13:41179580 C/G cg21288729 chr13:41239152 FOXO1 0.39 5.97 0.31 6.03e-9 Red blood cell count; CRC cis rs2251381 0.523 rs2832306 chr21:30754468 C/T cg08807101 chr21:30365312 RNF160 -0.49 -7.11 -0.36 7.23e-12 Selective IgA deficiency; CRC cis rs6973256 0.897 rs2909224 chr7:133331041 C/G cg10665199 chr7:133106180 EXOC4 -0.37 -5.66 -0.3 3.26e-8 Intelligence (multi-trait analysis); CRC cis rs1387259 0.690 rs1601985 chr12:48761914 A/G cg24011408 chr12:48396354 COL2A1 0.45 6.24 0.33 1.36e-9 Obstructive sleep apnea trait (apnea hypopnea index); CRC trans rs7800418 0.723 rs55716901 chr7:26590736 G/C cg14387656 chr2:233470847 EFHD1 0.47 6.43 0.33 4.6e-10 Cognitive function; CRC cis rs950776 0.720 rs11637890 chr15:78935419 C/G cg06917634 chr15:78832804 PSMA4 -0.49 -7.14 -0.37 5.95e-12 Sudden cardiac arrest; CRC cis rs6694672 1.000 rs12731209 chr1:196947139 C/T cg13682187 chr1:196946512 CFHR5 -0.47 -7.41 -0.38 1.1e-12 Asthma; CRC cis rs7274811 0.595 rs13045068 chr20:32133484 G/C cg07470512 chr20:32255052 NECAB3;C20orf134 -0.44 -5.66 -0.3 3.31e-8 Height; CRC cis rs9463078 0.653 rs6910974 chr6:45082169 A/T cg25276700 chr6:44698697 NA -0.24 -5.84 -0.31 1.22e-8 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; CRC trans rs2118666 0.590 rs13017777 chr2:223069625 T/C cg09178651 chr17:42459368 ITGA2B 0.38 6.0 0.31 5.08e-9 Information processing speed; CRC cis rs2153535 0.580 rs9392224 chr6:8472614 G/A cg07606381 chr6:8435919 SLC35B3 0.68 10.9 0.51 8.26e-24 Motion sickness; CRC cis rs4713118 0.786 rs200503 chr6:27785882 A/G cg15845792 chr6:28175446 NA 0.68 8.53 0.43 5.38e-16 Parkinson's disease; CRC cis rs1692580 0.870 rs590367 chr1:2162944 C/T cg24578937 chr1:2090814 PRKCZ 0.46 8.08 0.41 1.28e-14 Coronary artery disease; CRC cis rs7959452 0.536 rs4761237 chr12:69776461 C/G cg20891283 chr12:69753455 YEATS4 0.91 17.35 0.69 2.48e-48 Blood protein levels; CRC cis rs1832871 0.672 rs62437361 chr6:158728759 C/T cg07165851 chr6:158734300 TULP4 0.62 7.68 0.39 1.84e-13 Height; CRC trans rs7613875 0.620 rs13079006 chr3:49996924 G/T cg21665057 chr3:196295764 WDR53;FBXO45 0.44 6.32 0.33 8.6e-10 Body mass index; CRC cis rs13108904 0.934 rs13125842 chr4:1280947 G/A cg19318889 chr4:1322082 MAEA 0.4 5.72 0.3 2.35e-8 Obesity-related traits; CRC cis rs9648716 1.000 rs1267637 chr7:140473338 A/C cg10747023 chr7:140774559 NA 0.44 5.64 0.3 3.71e-8 Type 2 diabetes; CRC trans rs11148252 0.875 rs7987115 chr13:52962097 C/T cg18335740 chr13:41363409 SLC25A15 0.46 7.1 0.36 7.67e-12 Lewy body disease; CRC cis rs4843747 0.636 rs11864872 chr16:88105966 A/G cg17633681 chr16:88106987 BANP 0.87 16.25 0.67 5.17e-44 Menopause (age at onset); CRC trans rs637571 0.565 rs633800 chr11:65638719 G/A cg17712092 chr4:129076599 LARP1B -0.57 -8.87 -0.44 4.59e-17 Eosinophil percentage of white cells; CRC cis rs6952808 0.895 rs4513875 chr7:1928159 C/T cg21782813 chr7:2030301 MAD1L1 0.47 8.06 0.41 1.47e-14 Bipolar disorder and schizophrenia; CRC cis rs853679 0.542 rs2295594 chr6:28053097 G/A cg03623178 chr6:28175578 NA 0.94 12.29 0.56 7.67e-29 Depression; CRC cis rs9916302 0.706 rs9899069 chr17:37540772 A/G cg15445000 chr17:37608096 MED1 -0.35 -6.23 -0.32 1.43e-9 Glomerular filtration rate (creatinine); CRC cis rs10504229 0.654 rs903705 chr8:58128185 T/A cg05313129 chr8:58192883 C8orf71 -0.43 -6.11 -0.32 2.74e-9 Developmental language disorder (linguistic errors); CRC cis rs262150 0.788 rs2657408 chr7:158782275 A/G cg10570241 chr7:158785291 NA 0.41 7.09 0.36 8.45e-12 Facial morphology (factor 20); CRC cis rs7209700 0.547 rs8078614 chr17:45351505 C/T cg08085267 chr17:45401833 C17orf57 0.53 6.6 0.34 1.61e-10 IgG glycosylation; CRC cis rs9287719 0.967 rs10929688 chr2:10756650 T/C cg00105475 chr2:10696890 NA 0.45 7.24 0.37 3.21e-12 Prostate cancer; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg03130149 chr11:3819041 PGAP2;NUP98 0.54 7.24 0.37 3.21e-12 Thyroid stimulating hormone; CRC cis rs372883 0.613 rs1153290 chr21:30687404 G/T cg08807101 chr21:30365312 RNF160 -0.47 -6.67 -0.35 1.09e-10 Pancreatic cancer; CRC cis rs3806843 1.000 rs2240692 chr5:140183585 A/G cg16607685 chr5:140181889 PCDHA2;PCDHA1;PCDHA3 -0.27 -6.15 -0.32 2.3e-9 Depressive symptoms (multi-trait analysis); CRC cis rs9291683 0.526 rs6827785 chr4:10018205 C/T cg00071950 chr4:10020882 SLC2A9 0.62 11.19 0.53 7.38e-25 Bone mineral density; CRC trans rs9929218 0.954 rs72785165 chr16:68755635 T/A cg04657470 chr2:198365150 HSPE1;HSPD1 -0.97 -14.44 -0.62 5.77e-37 Colorectal cancer; CRC cis rs13315871 1.000 rs71311871 chr3:58420613 A/G cg20936604 chr3:58311152 NA -0.77 -7.23 -0.37 3.49e-12 Cholesterol, total; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg12112058 chr1:224622605 WDR26 0.44 6.54 0.34 2.39e-10 Response to antipsychotic treatment; CRC cis rs13392177 0.660 rs12988046 chr2:219073804 A/G cg04880052 chr2:219191631 PNKD -0.41 -6.08 -0.32 3.25e-9 Pyoderma gangrenosum in inflammatory bowel disease; CRC cis rs1799949 1.000 rs8176077 chr17:41276348 T/C cg05368731 chr17:41323189 NBR1 0.69 10.48 0.5 2.22e-22 Menopause (age at onset); CRC cis rs2408955 0.522 rs6580650 chr12:48418556 G/T cg00601486 chr12:48723148 H1FNT -0.33 -6.22 -0.32 1.53e-9 Glycated hemoglobin levels; CRC cis rs1707322 0.964 rs7512395 chr1:46361177 G/A cg03146154 chr1:46216737 IPP 0.58 8.04 0.41 1.69e-14 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs1957429 0.901 rs8009996 chr14:65351582 A/G cg23373153 chr14:65346875 NA 0.82 8.33 0.42 2.18e-15 Pediatric areal bone mineral density (radius); CRC cis rs561341 0.556 rs542244 chr17:30307242 T/C cg12193833 chr17:30244370 NA -0.75 -8.8 -0.44 7.92e-17 Hip circumference adjusted for BMI; CRC cis rs11971779 0.680 rs111461944 chr7:139077903 G/C cg23387468 chr7:139079360 LUC7L2 0.41 7.04 0.36 1.14e-11 Diisocyanate-induced asthma; CRC cis rs2882667 0.898 rs11952020 chr5:138395156 A/T cg04439458 chr5:138467593 SIL1 -0.31 -5.62 -0.3 3.97e-8 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs3889199 0.887 rs7534174 chr1:59661309 T/G cg25881383 chr1:59680599 NA -0.39 -6.23 -0.32 1.41e-9 Pulse pressure; CRC cis rs7811142 0.830 rs11768967 chr7:99967644 G/A cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.88 11.8 0.55 5.03e-27 Platelet count; CRC cis rs2242116 0.727 rs10865943 chr3:46969970 T/C cg27129171 chr3:47204927 SETD2 0.47 6.72 0.35 7.84e-11 Birth weight; CRC cis rs56399783 0.901 rs17132741 chr7:2868997 C/T cg19731401 chr7:2775893 GNA12 -0.47 -5.63 -0.3 3.89e-8 Childhood ear infection; CRC cis rs6694672 1.000 rs857021 chr1:197007479 A/G cg13682187 chr1:196946512 CFHR5 0.45 7.07 0.36 9.61e-12 Asthma; CRC cis rs9311474 0.632 rs6445528 chr3:52572447 C/T cg15147215 chr3:52552868 STAB1 0.68 12.41 0.56 2.87e-29 Electroencephalogram traits; CRC cis rs11677416 1.000 rs6542092 chr2:113528322 C/G cg27083787 chr2:113543245 IL1A 0.44 6.35 0.33 7.26e-10 Response to antipsychotic treatment in schizophrenia (working memory); CRC trans rs804280 0.560 rs10503426 chr8:11589383 A/C cg06636001 chr8:8085503 FLJ10661 0.55 8.4 0.42 1.32e-15 Myopia (pathological); CRC cis rs4631830 0.695 rs11004584 chr10:51500088 G/T cg20129853 chr10:51489980 NA -0.42 -7.13 -0.37 6.32e-12 Prostate-specific antigen levels; CRC cis rs8058578 1.000 rs56656810 chr16:30788759 C/A cg02466173 chr16:30829666 NA -0.85 -12.99 -0.58 2.01e-31 Multiple myeloma; CRC cis rs17270561 0.636 rs4360128 chr6:25734558 A/G cg16482183 chr6:26056742 HIST1H1C 0.83 10.58 0.5 1.07e-22 Iron status biomarkers; CRC cis rs12477438 0.520 rs6542869 chr2:99783403 G/A cg14399236 chr2:99771627 LIPT1;TSGA10 0.79 13.77 0.6 2.29e-34 Chronic sinus infection; CRC cis rs4862750 0.872 rs13110072 chr4:187878524 A/G cg06074448 chr4:187884817 NA -0.58 -10.87 -0.51 9.87e-24 Lobe attachment (rater-scored or self-reported); CRC cis rs2976388 0.590 rs4736322 chr8:143822208 T/C cg12516270 chr8:143859308 LYNX1 -0.39 -6.45 -0.33 4.08e-10 Urinary tract infection frequency; CRC cis rs8005677 1.000 rs8006396 chr14:23380850 A/G cg25600027 chr14:23388339 RBM23 -0.53 -8.37 -0.42 1.65e-15 Cognitive ability (multi-trait analysis); CRC cis rs4910157 1 rs4910157 chr11:8941215 A/G cg14711859 chr11:8959438 ASCL3 -0.42 -6.88 -0.35 3.09e-11 Tonsillectomy; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg27261641 chr11:95523641 FAM76B;CEP57 0.41 6.05 0.32 3.94e-9 Intelligence (multi-trait analysis); CRC trans rs2243480 1.000 rs1499614 chr7:65730798 A/T cg10756647 chr7:56101905 PSPH 0.76 7.91 0.4 3.95e-14 Diabetic kidney disease; CRC cis rs1158570 0.500 rs2554369 chr8:131314047 C/T cg21674704 chr8:131455249 NA -0.42 -6.36 -0.33 6.61e-10 Platelet count; CRC cis rs1448094 0.842 rs10863159 chr12:86459140 T/C cg18827107 chr12:86230957 RASSF9 0.36 5.69 0.3 2.79e-8 Major depressive disorder; CRC cis rs1355223 0.506 rs7131229 chr11:34869328 A/G cg11058730 chr11:34937778 PDHX;APIP 0.43 5.97 0.31 6.27e-9 Systemic lupus erythematosus and Systemic sclerosis; CRC cis rs7727544 0.684 rs274567 chr5:131714409 C/T cg07395648 chr5:131743802 NA 0.41 6.53 0.34 2.48e-10 Blood metabolite levels; CRC cis rs6088813 1.000 rs2425065 chr20:33926268 A/T cg14752227 chr20:34000481 UQCC 0.37 5.77 0.3 1.83e-8 Height; CRC cis rs9916302 0.706 rs4795385 chr17:37733148 A/G cg07936489 chr17:37558343 FBXL20 0.93 11.32 0.53 2.62e-25 Glomerular filtration rate (creatinine); CRC cis rs6951245 1.000 rs11763793 chr7:1094342 A/G cg18402987 chr7:1209562 NA 0.68 7.29 0.37 2.35e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs8177253 0.761 rs35332919 chr3:133519002 T/A cg08048268 chr3:133502702 NA -0.47 -8.98 -0.44 2.06e-17 Iron status biomarkers; CRC cis rs2032447 0.869 rs2230655 chr6:26033506 A/G cg04800585 chr6:26043546 HIST1H2BB -0.58 -8.61 -0.43 3.16e-16 Intelligence (multi-trait analysis); CRC cis rs2228479 0.850 rs2238531 chr16:89856217 C/G cg06558623 chr16:89946397 TCF25 1.16 11.41 0.53 1.27e-25 Skin colour saturation; CRC trans rs6928289 0.545 rs12207738 chr6:137674945 C/G cg20212336 chr13:111268714 CARKD 0.4 6.04 0.32 4.25e-9 Thiazide-induced adverse metabolic effects in hypertensive patients; CRC trans rs3857536 0.611 rs6927407 chr6:66870010 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.49 -6.51 -0.34 2.83e-10 Blood trace element (Cu levels); CRC cis rs910316 0.737 rs175072 chr14:75502827 T/C cg08847533 chr14:75593920 NEK9 -0.82 -14.49 -0.62 3.79e-37 Height; CRC cis rs6842789 0.510 rs11098725 chr4:124919843 C/T cg01723706 chr4:124814442 LOC285419 0.37 5.81 0.31 1.45e-8 Neuroticism; CRC cis rs57221529 0.713 rs56328416 chr5:591138 G/A cg17948913 chr5:572064 NA 0.53 5.94 0.31 7.17e-9 Lung disease severity in cystic fibrosis; CRC cis rs13217239 0.646 rs12209886 chr6:26984757 G/A cg12292205 chr6:26970375 C6orf41 0.56 9.32 0.46 1.78e-18 Schizophrenia; CRC cis rs611744 0.517 rs62537573 chr8:109269281 C/T cg21045802 chr8:109455806 TTC35 0.46 7.02 0.36 1.24e-11 Dupuytren's disease; CRC trans rs877282 0.945 rs11253390 chr10:788678 A/G cg22713356 chr15:30763199 NA 1.35 16.39 0.67 1.43e-44 Uric acid levels; CRC cis rs11758351 1.000 rs3734530 chr6:26195408 G/C cg22723502 chr6:26240528 HIST1H4F -0.38 -5.83 -0.31 1.35e-8 Gout;Renal underexcretion gout; CRC cis rs5769765 0.773 rs58375955 chr22:50312630 A/G cg22709217 chr22:50311962 ALG12;CRELD2 -1.12 -18.26 -0.71 6.49e-52 Schizophrenia; CRC cis rs514406 0.861 rs4926576 chr1:53226775 C/T cg25767906 chr1:53392781 SCP2 0.45 7.12 0.37 6.95e-12 Monocyte count; CRC cis rs290268 0.669 rs10993693 chr9:93557698 C/T cg02608019 chr9:93564028 SYK 0.47 7.16 0.37 5.29e-12 Platelet count; CRC cis rs951366 0.789 rs823130 chr1:205714372 C/T cg23034840 chr1:205782522 SLC41A1 0.47 6.44 0.33 4.32e-10 Menarche (age at onset); CRC cis rs1656402 1.000 rs4973544 chr2:233435535 G/A cg03852847 chr2:233439513 NA -0.43 -6.97 -0.36 1.75e-11 Non-small cell lung cancer (survival); CRC cis rs9322193 0.923 rs9322208 chr6:149979683 A/T cg07701084 chr6:150067640 NUP43 0.56 8.22 0.41 4.65e-15 Lung cancer; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg16196077 chr10:64028521 RTKN2 0.36 6.27 0.33 1.13e-9 Liver disease severity in Alagille syndrome; CRC cis rs6604026 0.922 rs35051335 chr1:93295830 A/G cg17283838 chr1:93427260 FAM69A 0.45 5.68 0.3 2.92e-8 Multiple sclerosis; CRC trans rs12699921 0.568 rs2691605 chr7:17877448 T/C cg02066331 chr6:17282778 RBM24 -0.36 -6.18 -0.32 1.89e-9 Fibrinogen levels; CRC cis rs7814319 0.933 rs7827095 chr8:97239126 C/T cg20787634 chr8:97240163 UQCRB 0.52 9.12 0.45 7.6e-18 Lung function (FVC); CRC cis rs10876993 0.789 rs1689600 chr12:58049645 A/T cg15848620 chr12:58087721 OS9 -0.65 -8.94 -0.44 2.86e-17 Celiac disease or Rheumatoid arthritis; CRC trans rs1455244 0.700 rs7229302 chr18:11508904 G/T cg05862135 chr16:3074294 HCFC1R1;THOC6 0.39 6.21 0.32 1.6e-9 Schizophrenia; CRC cis rs9311676 0.632 rs11714389 chr3:58447299 C/T cg06643156 chr3:58380774 PXK 0.44 6.73 0.35 7.61e-11 Systemic lupus erythematosus; CRC trans rs11098499 0.754 rs12506487 chr4:120271361 T/G cg25214090 chr10:38739885 LOC399744 0.53 8.51 0.42 6.28e-16 Corneal astigmatism; CRC cis rs12928939 0.911 rs11645725 chr16:71826883 C/T cg08717414 chr16:71523259 ZNF19 -0.51 -6.32 -0.33 8.64e-10 Post bronchodilator FEV1; CRC cis rs17270561 0.609 rs9379785 chr6:25726213 G/A cg16482183 chr6:26056742 HIST1H1C 0.82 10.51 0.5 1.88e-22 Iron status biomarkers; CRC cis rs875971 0.706 rs1643374 chr7:65872682 T/A cg00343986 chr7:65444356 GUSB 0.46 6.62 0.34 1.49e-10 Aortic root size; CRC cis rs8060686 0.516 rs8048365 chr16:68253326 T/A cg26727032 chr16:67993705 SLC12A4 -0.63 -9.56 -0.47 2.92e-19 HDL cholesterol;Metabolic syndrome; CRC cis rs10883723 0.810 rs10748823 chr10:104274465 C/G cg11453585 chr10:104263688 ACTR1A;SUFU 0.91 17.43 0.69 1.17e-48 Allergic disease (asthma, hay fever or eczema); CRC cis rs2832191 0.791 rs8134407 chr21:30476586 G/A cg08807101 chr21:30365312 RNF160 0.64 10.28 0.49 1.11e-21 Dental caries; CRC cis rs12477438 0.520 rs2969379 chr2:99776686 G/A cg14399236 chr2:99771627 LIPT1;TSGA10 0.82 14.56 0.63 2.05e-37 Chronic sinus infection; CRC cis rs6500602 0.702 rs6500606 chr16:4502514 A/G cg14951292 chr16:4525986 HMOX2;NMRAL1 -0.61 -9.5 -0.46 4.5e-19 Schizophrenia; CRC cis rs4713118 0.869 rs9393851 chr6:27699581 A/T cg26587870 chr6:27730563 NA -0.43 -6.72 -0.35 8.04e-11 Parkinson's disease; CRC cis rs533581 0.866 rs562812 chr16:88970944 G/A cg09141835 chr16:88988174 CBFA2T3 -0.26 -5.64 -0.3 3.59e-8 Social autistic-like traits; CRC cis rs7772486 0.817 rs9386145 chr6:146363519 A/T cg23711669 chr6:146136114 FBXO30 0.68 11.85 0.55 3.22e-27 Lobe attachment (rater-scored or self-reported); CRC cis rs66887589 0.934 rs12648182 chr4:120503891 T/A cg09307838 chr4:120376055 NA -0.51 -7.76 -0.39 1.1e-13 Diastolic blood pressure; CRC cis rs7618915 0.571 rs2289249 chr3:52597664 G/A cg18404041 chr3:52824283 ITIH1 -0.43 -8.97 -0.44 2.23e-17 Bipolar disorder; CRC cis rs12760731 0.920 rs34440664 chr1:178477925 G/T cg00404053 chr1:178313656 RASAL2 0.86 8.35 0.42 1.88e-15 Obesity-related traits; CRC cis rs7940866 0.834 rs10791105 chr11:130839161 A/G cg12179176 chr11:130786555 SNX19 0.59 8.53 0.43 5.61e-16 Schizophrenia; CRC cis rs10876993 0.890 rs10783844 chr12:58098425 A/C cg18357645 chr12:58087776 OS9 0.61 8.64 0.43 2.54e-16 Celiac disease or Rheumatoid arthritis; CRC cis rs60843830 1.000 rs79716074 chr2:277003 A/G cg00108164 chr2:264199 ACP1;SH3YL1 0.62 9.74 0.47 7.19e-20 Spherical equivalent (joint analysis main effects and education interaction); CRC cis rs7927592 0.763 rs10791982 chr11:68337664 T/G cg16797656 chr11:68205561 LRP5 -0.48 -8.81 -0.44 7.17e-17 Total body bone mineral density; CRC cis rs4713118 0.523 rs2179096 chr6:27665920 C/T cg12172441 chr6:28176163 NA 0.45 6.35 0.33 7.17e-10 Parkinson's disease; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg17956079 chr11:73358572 PLEKHB1 0.52 7.27 0.37 2.6e-12 Thyroid stimulating hormone; CRC cis rs6499255 0.951 rs8045705 chr16:69581672 A/G cg04110750 chr16:69646130 NFAT5 -0.52 -7.11 -0.37 7.18e-12 IgE levels; CRC cis rs10504229 0.953 rs6991035 chr8:58183374 C/T cg24829409 chr8:58192753 C8orf71 -0.68 -11.34 -0.53 2.27e-25 Developmental language disorder (linguistic errors); CRC cis rs6502050 0.835 rs11654584 chr17:80079435 A/T cg13198984 chr17:80129470 CCDC57 0.47 8.12 0.41 9.18e-15 Life satisfaction; CRC cis rs4901869 0.966 rs1820557 chr14:59334863 C/G cg02291164 chr14:59296302 NA 0.34 6.3 0.33 9.8e-10 Panic disorder; CRC cis rs7772486 0.686 rs6933161 chr6:146081369 G/A cg13319975 chr6:146136371 FBXO30 0.43 6.41 0.33 5.09e-10 Lobe attachment (rater-scored or self-reported); CRC cis rs4074493 1.000 rs4378192 chr1:231173379 C/T cg22172038 chr1:231176991 FAM89A 0.34 5.9 0.31 9.23e-9 Carotid plaque burden (smoking interaction); CRC cis rs9811920 0.809 rs766778 chr3:99751480 C/T cg07805332 chr3:99536008 MIR548G;C3orf26 0.41 6.37 0.33 6.2e-10 Axial length; CRC cis rs3740540 0.507 rs2362500 chr10:126290431 T/C cg04949429 chr10:126290192 LHPP 0.43 6.35 0.33 6.99e-10 Obesity-related traits;Acute lymphoblastic leukemia (childhood); CRC cis rs9287719 0.649 rs6730247 chr2:10725888 G/C cg00105475 chr2:10696890 NA 0.44 7.0 0.36 1.43e-11 Prostate cancer; CRC cis rs7666738 0.830 rs1967980 chr4:98966426 C/G cg17366294 chr4:99064904 C4orf37 0.43 7.17 0.37 5.01e-12 Colonoscopy-negative controls vs population controls; CRC cis rs6831352 0.879 rs17218003 chr4:100054723 G/C cg13256891 chr4:100009986 ADH5 -0.66 -8.89 -0.44 4.04e-17 Alcohol dependence; CRC cis rs9818758 0.607 rs4855860 chr3:49526044 A/T cg00383909 chr3:49044727 WDR6 -1.11 -10.01 -0.48 9.26e-21 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; CRC cis rs995000 0.931 rs642845 chr1:62908235 T/C cg19896129 chr1:63156450 NA 0.44 6.84 0.35 3.76e-11 Triglyceride levels; CRC cis rs875971 0.862 rs1981799 chr7:65955559 T/C cg18876405 chr7:65276391 NA 0.52 8.9 0.44 3.86e-17 Aortic root size; CRC cis rs734999 0.967 rs6672381 chr1:2502834 A/G cg18854424 chr1:2615690 NA 0.34 6.39 0.33 5.68e-10 Ulcerative colitis; CRC cis rs68170813 0.559 rs6946036 chr7:106853659 G/A cg02696742 chr7:106810147 HBP1 -0.6 -6.58 -0.34 1.83e-10 Coronary artery disease; CRC cis rs896854 0.818 rs896855 chr8:95959808 A/G cg23172400 chr8:95962367 TP53INP1 -0.48 -8.11 -0.41 9.85e-15 Type 2 diabetes; CRC cis rs4819052 0.851 rs914214 chr21:46697820 G/T cg11663144 chr21:46675770 NA -0.85 -14.55 -0.63 2.21e-37 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC trans rs4263408 0.934 rs9683743 chr4:39703194 A/C cg15368822 chr1:226070397 TMEM63A -0.41 -6.04 -0.32 4.22e-9 Plasma amyloid beta peptide concentrations (ABx-40); CRC trans rs3749237 0.964 rs2352967 chr3:49871641 C/T cg21659725 chr3:3221576 CRBN 0.58 8.35 0.42 1.96e-15 Resting heart rate; CRC cis rs12900413 0.687 rs28435184 chr15:90306732 T/C cg24249390 chr15:90295951 MESP1 -0.59 -9.31 -0.46 1.87e-18 Coronary artery aneurysm in Kawasaki disease; CRC trans rs4813802 0.724 rs2876052 chr20:6711572 C/T cg17393568 chr4:190861806 FRG1 0.5 6.08 0.32 3.3e-9 Colorectal cancer; CRC trans rs1607741 1.000 rs10000244 chr4:72711845 A/G cg06437464 chr6:127441704 RSPO3 0.29 6.16 0.32 2.06e-9 Vitamin D levels; CRC cis rs4936891 0.599 rs729775 chr11:123910401 C/A cg22125253 chr11:123886957 OR10G4 -0.32 -5.94 -0.31 7.15e-9 Male fertility; CRC cis rs10512697 0.655 rs13173969 chr5:3487526 G/A cg19473799 chr5:3511975 NA -0.83 -6.35 -0.33 7.32e-10 Immune response to smallpox vaccine (IL-6); CRC cis rs9916302 0.706 rs9893735 chr17:37469858 A/C cg07936489 chr17:37558343 FBXL20 0.84 10.61 0.5 8.08e-23 Glomerular filtration rate (creatinine); CRC cis rs11955398 0.692 rs897672 chr5:59996101 C/G cg02684056 chr5:59996105 DEPDC1B 0.41 5.86 0.31 1.12e-8 Intelligence (multi-trait analysis); CRC cis rs9303280 0.806 rs62067034 chr17:38063738 C/T cg20243544 chr17:37824526 PNMT 0.46 7.09 0.36 8.38e-12 Self-reported allergy; CRC cis rs7772486 0.875 rs1331640 chr6:146427250 G/A cg23711669 chr6:146136114 FBXO30 0.67 11.74 0.54 8.1e-27 Lobe attachment (rater-scored or self-reported); CRC cis rs713587 0.646 rs2384061 chr2:25135620 C/T cg04586622 chr2:25135609 ADCY3 -0.67 -13.75 -0.6 2.66e-34 Body mass index in non-asthmatics; CRC cis rs2304069 0.954 rs1962603 chr5:149393006 G/T cg22760475 chr5:149380129 HMGXB3;TIGD6 0.88 10.04 0.48 7.31e-21 HIV-1 control; CRC cis rs2290416 0.892 rs76108894 chr8:144673533 G/A cg08017634 chr8:144659831 NAPRT1 0.67 5.72 0.3 2.44e-8 Attention deficit hyperactivity disorder; CRC cis rs5750830 0.649 rs5750822 chr22:39826788 C/T cg11247378 chr22:39784982 NA -0.47 -9.16 -0.45 5.73e-18 Intelligence (multi-trait analysis); CRC cis rs763014 0.932 rs35067229 chr16:649638 T/C cg08989290 chr16:615782 NHLRC4 0.48 9.41 0.46 8.82e-19 Height; CRC cis rs4689388 0.853 rs11729672 chr4:6293838 A/G cg00701064 chr4:6280414 WFS1 0.75 13.24 0.59 2.22e-32 Type 2 diabetes and other traits;Type 2 diabetes; CRC trans rs12599106 0.560 rs34151874 chr16:34989694 G/A cg15383120 chr6:291909 DUSP22 -0.59 -8.21 -0.41 5.02e-15 Menopause (age at onset); CRC cis rs972578 0.837 rs6002964 chr22:43246248 G/T cg01576275 chr22:43409880 NA -0.4 -6.21 -0.32 1.61e-9 Mean platelet volume; CRC cis rs6582630 0.555 rs7133706 chr12:38475465 G/A cg13010199 chr12:38710504 ALG10B -0.47 -6.6 -0.34 1.63e-10 Drug-induced liver injury (flucloxacillin); CRC cis rs77861329 1.000 rs164639 chr3:52210872 A/G cg08692210 chr3:52188851 WDR51A -0.77 -7.58 -0.39 3.47e-13 Macrophage inflammatory protein 1b levels; CRC cis rs9814567 1.000 rs13081177 chr3:134289860 A/G cg06109529 chr3:134205091 CEP63;ANAPC13 0.84 12.35 0.56 4.67e-29 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs9894429 0.646 rs7220310 chr17:79606056 C/A cg21028142 chr17:79581711 NPLOC4 0.35 7.29 0.37 2.38e-12 Eye color traits; CRC cis rs1953600 0.837 rs3098105 chr10:81953266 C/T cg04850286 chr10:81895943 PLAC9 0.37 6.71 0.35 8.44e-11 Sarcoidosis; CRC cis rs7705042 0.828 rs11750521 chr5:141500704 T/C cg07392085 chr5:141489673 NDFIP1 0.47 7.42 0.38 1.03e-12 Asthma; CRC cis rs62229266 0.804 rs12483151 chr21:37419578 C/T cg08632701 chr21:37451849 NA -0.45 -7.09 -0.36 8.4e-12 Mitral valve prolapse; CRC cis rs7487075 0.893 rs1471223 chr12:46727770 A/C cg22049899 chr12:47219821 SLC38A4 -0.35 -6.9 -0.36 2.67e-11 Itch intensity from mosquito bite; CRC cis rs9487051 0.768 rs398944 chr6:109523444 T/G cg21918786 chr6:109611834 NA -0.33 -5.63 -0.3 3.77e-8 Reticulocyte fraction of red cells; CRC cis rs11098499 0.863 rs3775849 chr4:120450908 G/C cg09307838 chr4:120376055 NA 0.69 10.34 0.5 6.68e-22 Corneal astigmatism; CRC cis rs262150 0.501 rs2730206 chr7:158815173 G/C cg10570241 chr7:158785291 NA 0.38 6.5 0.34 2.97e-10 Facial morphology (factor 20); CRC cis rs7192380 0.630 rs2965749 chr16:69771914 C/T cg00738113 chr16:70207722 CLEC18C 0.43 7.47 0.38 7.16e-13 Sjögren's syndrome; CRC cis rs9389248 0.690 rs2072826 chr6:135253558 G/C cg24558204 chr6:135376177 HBS1L -0.54 -7.86 -0.4 5.72e-14 High light scatter reticulocyte percentage of red cells; CRC cis rs875971 0.522 rs2949690 chr7:65483242 C/T cg02869306 chr7:64672164 INTS4L1 0.35 5.76 0.3 1.95e-8 Aortic root size; CRC cis rs2976388 1.000 rs2920296 chr8:143763109 A/G cg24046110 chr8:143859143 LYNX1 -0.37 -6.32 -0.33 8.7e-10 Urinary tract infection frequency; CRC cis rs2836974 0.965 rs8134733 chr21:40683459 C/T cg11890956 chr21:40555474 PSMG1 1.07 17.4 0.69 1.61e-48 Cognitive function; CRC cis rs6684514 1.000 rs12038481 chr1:156284815 T/C cg16558208 chr1:156270281 VHLL 0.58 8.92 0.44 3.2e-17 Mean corpuscular hemoglobin concentration;Glycated hemoglobin levels; CRC cis rs6499255 0.951 rs2361838 chr16:69676086 T/C cg04110750 chr16:69646130 NFAT5 -0.53 -7.27 -0.37 2.62e-12 IgE levels; CRC cis rs10504229 1.000 rs17216957 chr8:58179893 C/T cg02290350 chr8:58132656 NA -0.42 -5.96 -0.31 6.62e-9 Developmental language disorder (linguistic errors); CRC trans rs6546043 0.667 rs7596262 chr2:64149819 T/G cg20306022 chr2:7947960 NA -0.51 -6.17 -0.32 2.02e-9 Clozapine-induced agranulocytosis; CRC cis rs17209837 0.607 rs1473152 chr7:87080350 A/C cg00919237 chr7:87102261 ABCB4 -0.53 -7.04 -0.36 1.12e-11 Gallbladder cancer; CRC cis rs875971 0.545 rs17138156 chr7:65714695 C/T cg03233332 chr7:66118400 NA -0.44 -6.24 -0.33 1.31e-9 Aortic root size; CRC cis rs12477438 0.520 rs6741773 chr2:99738962 A/C cg14399236 chr2:99771627 LIPT1;TSGA10 0.82 14.31 0.62 1.84e-36 Chronic sinus infection; CRC cis rs72945132 0.619 rs34053053 chr11:70260598 C/T cg14191688 chr11:70257035 CTTN 0.7 8.85 0.44 5.67e-17 Coronary artery disease; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg22522926 chr2:131851181 FAM168B 0.49 6.34 0.33 7.55e-10 Thyroid stimulating hormone; CRC cis rs644799 0.544 rs1622515 chr11:95523433 A/G cg25622487 chr11:95524042 FAM76B;CEP57 0.59 8.8 0.44 8.11e-17 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs2952156 0.684 rs1877031 chr17:37814080 G/A cg00129232 chr17:37814104 STARD3 -0.7 -12.41 -0.56 2.76e-29 Asthma; CRC cis rs8077889 0.719 rs57227660 chr17:41858984 T/C cg25876840 chr17:41920477 NA 0.41 6.52 0.34 2.68e-10 Triglycerides; CRC trans rs34043159 1.000 rs2286240 chr2:102440166 G/A cg23013864 chr6:17393396 CAP2 0.41 6.0 0.31 5.24e-9 Parkinson's disease; CRC cis rs10540 0.908 rs1044707 chr11:491334 G/T cg03934478 chr11:495069 RNH1 -0.69 -7.86 -0.4 5.52e-14 Body mass index; CRC cis rs113835537 0.935 rs79106199 chr11:66420518 T/C cg22134325 chr11:66188745 NPAS4 0.41 6.71 0.35 8.55e-11 Airway imaging phenotypes; CRC cis rs7647973 0.626 rs2329021 chr3:49679072 G/A cg03060546 chr3:49711283 APEH 0.68 8.2 0.41 5.37e-15 Menarche (age at onset); CRC trans rs6951245 1.000 rs77346188 chr7:1114023 C/A cg13565492 chr6:43139072 SRF -0.73 -7.52 -0.38 5.23e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs425277 0.606 rs12082939 chr1:2078922 C/T cg04315214 chr1:2043799 PRKCZ -0.35 -6.08 -0.32 3.38e-9 Height; CRC cis rs1865760 0.516 rs9379819 chr6:26049819 A/C cg18357526 chr6:26021779 HIST1H4A 0.43 6.07 0.32 3.55e-9 Height; CRC trans rs1005277 0.579 rs2504148 chr10:38400788 A/G cg27523141 chr10:43048294 ZNF37B 0.49 7.24 0.37 3.25e-12 Extrinsic epigenetic age acceleration; CRC cis rs9372498 0.536 rs9489477 chr6:118946192 T/G cg22561889 chr6:118971681 C6orf204 0.52 6.62 0.34 1.45e-10 Diastolic blood pressure; CRC cis rs9388451 0.874 rs7739566 chr6:126094757 A/T cg05901451 chr6:126070800 HEY2 -0.65 -11.23 -0.53 5.35e-25 Brugada syndrome; CRC cis rs2204008 0.542 rs34770471 chr12:38009613 C/T cg26384229 chr12:38710491 ALG10B 0.68 8.95 0.44 2.57e-17 Bladder cancer; CRC cis rs3733585 0.534 rs7375642 chr4:9955236 A/G cg11266682 chr4:10021025 SLC2A9 -0.47 -9.59 -0.47 2.27e-19 Cleft plate (environmental tobacco smoke interaction); CRC cis rs3820068 0.581 rs67806552 chr1:15927138 T/C cg27534772 chr1:16042836 PLEKHM2 0.55 10.92 0.52 6.82e-24 Systolic blood pressure; CRC cis rs9381040 0.610 rs2235679 chr6:41020577 G/T cg25110423 chr6:41068646 NFYA;LOC221442 -0.38 -5.83 -0.31 1.29e-8 Alzheimer's disease (late onset); CRC cis rs7618915 0.501 rs7611731 chr3:52692721 T/C cg18404041 chr3:52824283 ITIH1 -0.41 -8.66 -0.43 2.11e-16 Bipolar disorder; CRC cis rs2243480 1.000 rs34637256 chr7:65360131 G/A cg18252515 chr7:66147081 NA -1.17 -13.57 -0.6 1.26e-33 Diabetic kidney disease; CRC cis rs35520189 0.591 rs12614988 chr2:113702178 A/C cg12858261 chr2:113808755 IL1F8 0.49 6.87 0.35 3.29e-11 Obstructive sleep apnea trait (apnea hypopnea index); CRC cis rs12760731 0.517 rs11587387 chr1:178229950 C/T cg00404053 chr1:178313656 RASAL2 1.03 10.81 0.51 1.61e-23 Obesity-related traits; CRC cis rs10504229 0.593 rs58647001 chr8:58025132 G/A cg02725872 chr8:58115012 NA -0.41 -7.38 -0.38 1.27e-12 Developmental language disorder (linguistic errors); CRC cis rs60733400 0.818 rs10909839 chr1:2708430 G/A cg20673091 chr1:2541236 MMEL1 0.36 5.72 0.3 2.44e-8 Multiple sclerosis; CRC trans rs58106596 0.517 rs56272010 chr2:232664963 T/G cg01370599 chr3:116745421 NA 0.46 6.02 0.31 4.64e-9 White blood cell count;Lymphocyte counts; CRC trans rs10982213 0.830 rs2274163 chr9:117188714 C/T cg14086160 chr1:159895389 TAGLN2 0.38 5.99 0.31 5.57e-9 Interleukin-6 levels; CRC cis rs2952156 0.834 rs903503 chr17:37829571 C/A cg11212589 chr17:38028394 ZPBP2 0.34 5.93 0.31 7.48e-9 Asthma; CRC cis rs4663866 1.000 rs4663865 chr2:239145960 C/T cg16914508 chr2:239161102 PER2 -0.68 -7.52 -0.38 5.15e-13 Irritable bowel syndrome; CRC cis rs9326248 1.000 rs10790175 chr11:117034729 A/G cg15534755 chr11:117069859 TAGLN 0.33 6.32 0.33 8.44e-10 Blood protein levels; CRC cis rs10751667 0.666 rs7123912 chr11:963936 T/C ch.11.42038R chr11:967971 AP2A2 0.58 9.98 0.48 1.16e-20 Alzheimer's disease (late onset); CRC cis rs7666738 0.830 rs34461023 chr4:99023751 C/T cg05340658 chr4:99064831 C4orf37 0.61 9.35 0.46 1.39e-18 Colonoscopy-negative controls vs population controls; CRC cis rs11212617 0.934 rs679782 chr11:108116700 T/C cg01991180 chr11:108092276 ATM;NPAT 0.4 5.65 0.3 3.57e-8 Response to metformin in type 2 diabetes (glycemic); CRC trans rs7395662 0.677 rs10839110 chr11:48839960 T/C cg21153622 chr11:89784906 NA -0.49 -7.75 -0.39 1.16e-13 HDL cholesterol; CRC cis rs10540 1.000 rs12419716 chr11:503385 C/G cg03352830 chr11:487213 PTDSS2 0.67 7.71 0.39 1.48e-13 Body mass index; CRC cis rs8177253 1.000 rs6439439 chr3:133481498 G/T cg01448562 chr3:133502909 NA -0.53 -9.03 -0.45 1.44e-17 Iron status biomarkers; CRC cis rs868036 1.000 rs1026734 chr15:68100950 T/C cg05925327 chr15:68127851 NA -0.31 -6.0 -0.31 5.18e-9 Restless legs syndrome; CRC cis rs3087591 0.960 rs6505232 chr17:29611411 T/C cg24425628 chr17:29625626 OMG;NF1 -0.88 -16.87 -0.68 1.83e-46 Hip circumference; CRC cis rs172166 0.611 rs203882 chr6:28078502 G/A cg03623178 chr6:28175578 NA 0.79 11.41 0.53 1.22e-25 Cardiac Troponin-T levels; CRC trans rs4942242 0.663 rs1472330 chr13:44209628 A/G cg26741380 chr15:41871084 TYRO3 0.45 6.2 0.32 1.73e-9 Response to tocilizumab in rheumatoid arthritis; CRC cis rs7584330 0.518 rs80282956 chr2:238447929 G/A cg08992911 chr2:238395768 MLPH 0.62 6.33 0.33 8.16e-10 Prostate cancer; CRC cis rs2354432 0.607 rs6694347 chr1:146751140 T/C cg25205988 chr1:146714368 CHD1L -1.24 -9.92 -0.48 1.84e-20 Mitochondrial DNA levels; CRC cis rs9393777 0.588 rs11967935 chr6:26560672 A/C cg12292205 chr6:26970375 C6orf41 -0.58 -6.32 -0.33 8.32e-10 Intelligence (multi-trait analysis); CRC cis rs7927592 0.731 rs643609 chr11:68241833 A/G cg16797656 chr11:68205561 LRP5 0.49 9.03 0.45 1.45e-17 Total body bone mineral density; CRC cis rs7615952 0.576 rs6780025 chr3:125815624 A/C cg05084668 chr3:125655381 ALG1L -0.46 -6.46 -0.34 3.68e-10 Blood pressure (smoking interaction); CRC cis rs6496667 0.865 rs7171422 chr15:90904741 G/A cg04176472 chr15:90893244 GABARAPL3 0.61 8.24 0.41 4.08e-15 Rheumatoid arthritis; CRC cis rs611744 0.625 rs4735055 chr8:109286642 G/A cg18478394 chr8:109455254 TTC35 0.39 5.86 0.31 1.11e-8 Dupuytren's disease; CRC trans rs61931739 0.500 rs11053185 chr12:34428857 A/G cg13010199 chr12:38710504 ALG10B 0.44 6.29 0.33 9.83e-10 Morning vs. evening chronotype; CRC cis rs4713118 0.824 rs9366702 chr6:27734470 T/C cg08798685 chr6:27730294 NA -0.51 -7.12 -0.37 6.75e-12 Parkinson's disease; CRC trans rs1005277 0.579 rs2472178 chr10:38384750 T/C cg17830980 chr10:43048298 ZNF37B -0.57 -9.52 -0.46 3.76e-19 Extrinsic epigenetic age acceleration; CRC cis rs9346649 0.583 rs4708642 chr6:168491500 G/A cg02770688 chr6:168491649 NA 0.63 9.28 0.46 2.38e-18 Venous thromboembolism adjusted for sickle cell variant rs77121243-T; CRC cis rs2252790 1.000 rs2498703 chr6:116660670 A/T cg18764771 chr6:116381957 FRK -0.22 -5.94 -0.31 7.42e-9 Fast beta electroencephalogram; CRC cis rs875971 0.540 rs35510581 chr7:65578777 G/A cg11764359 chr7:65958608 NA -0.55 -8.54 -0.43 5.05e-16 Aortic root size; CRC cis rs7677751 0.767 rs6554158 chr4:55066077 G/A cg00691999 chr4:55094011 PDGFRA 0.4 5.6 0.3 4.51e-8 Corneal astigmatism; CRC cis rs10791323 0.569 rs329664 chr11:133754975 G/T cg06766960 chr11:133703094 NA -0.34 -6.19 -0.32 1.79e-9 Childhood ear infection; CRC cis rs10791323 0.604 rs2853116 chr11:133707063 A/G cg06766960 chr11:133703094 NA -0.37 -6.17 -0.32 1.99e-9 Childhood ear infection; CRC trans rs35110281 0.714 rs7277539 chr21:45053011 A/G cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.51 8.5 0.42 6.61e-16 Mean corpuscular volume; CRC cis rs977987 0.843 rs10459859 chr16:75381950 T/C cg03315344 chr16:75512273 CHST6 0.51 8.71 0.43 1.48e-16 Dupuytren's disease; CRC cis rs9910055 0.530 rs2269905 chr17:42294462 A/G cg13607699 chr17:42295918 UBTF 0.81 14.4 0.62 8.38e-37 Total body bone mineral density; CRC cis rs6696846 0.765 rs61822565 chr1:205077332 T/C cg00857998 chr1:205179979 DSTYK 0.45 6.29 0.33 1e-9 Red blood cell count; CRC cis rs73206853 0.563 rs34378671 chr12:111163204 C/T cg12870014 chr12:110450643 ANKRD13A 0.75 8.94 0.44 2.88e-17 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC cis rs7224685 0.569 rs8065660 chr17:4000858 A/G cg11204139 chr17:3907470 NA 0.51 6.5 0.34 3.06e-10 Type 2 diabetes; CRC cis rs6089584 0.606 rs7270666 chr20:60577598 C/T cg23262073 chr20:60523788 NA -0.38 -6.74 -0.35 7.05e-11 Body mass index; CRC cis rs78707713 0.560 rs61848436 chr10:71247714 C/T cg12610070 chr10:71211762 TSPAN15 -0.41 -7.21 -0.37 3.93e-12 Venous thromboembolism; CRC cis rs9910055 0.659 rs7214540 chr17:42256604 A/G cg10896456 chr17:42255109 ASB16;C17orf65 0.45 7.78 0.39 9.4e-14 Total body bone mineral density; CRC cis rs1005277 0.602 rs2504142 chr10:38383793 C/T cg25517755 chr10:38738941 LOC399744 -0.44 -6.42 -0.33 4.85e-10 Extrinsic epigenetic age acceleration; CRC cis rs6951245 1.000 rs113575110 chr7:1084394 G/A cg21664854 chr7:1097933 C7orf50;GPR146 0.79 8.96 0.44 2.48e-17 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC trans rs208520 0.690 rs1738970 chr6:66809491 T/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.08 -15.42 -0.65 9.04e-41 Exhaled nitric oxide output; CRC cis rs7264396 0.690 rs2425164 chr20:34434916 G/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.6 -10.15 -0.49 2.96e-21 Total cholesterol levels; CRC cis rs58688157 0.705 rs7122021 chr11:595810 A/G cg03909863 chr11:638404 DRD4 -0.53 -7.14 -0.37 6.12e-12 Systemic lupus erythematosus; CRC cis rs4731207 0.698 rs10228682 chr7:124538036 C/T cg23710748 chr7:124431027 NA -0.38 -6.06 -0.32 3.65e-9 Cutaneous malignant melanoma; CRC cis rs1707322 0.721 rs9793568 chr1:46130373 G/A cg06784218 chr1:46089804 CCDC17 0.66 12.35 0.56 4.77e-29 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs9649213 0.537 rs35997266 chr7:97965566 T/C cg00277769 chr7:97922759 BAIAP2L1 -0.61 -10.51 -0.5 1.87e-22 Prostate cancer (SNP x SNP interaction); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg17968077 chr19:18314992 RAB3A 0.43 6.07 0.32 3.47e-9 Response to antipsychotic treatment; CRC trans rs1814175 0.645 rs28478790 chr11:50054322 C/A cg11707556 chr5:10655725 ANKRD33B -0.5 -9.83 -0.48 3.72e-20 Height; CRC cis rs17826219 0.636 rs2449770 chr17:29101064 G/T cg01831904 chr17:28903510 LRRC37B2 -0.63 -6.53 -0.34 2.51e-10 Body mass index; CRC cis rs12519773 0.525 rs57542119 chr5:92538853 T/C cg18783429 chr5:92414398 NA 0.28 6.01 0.31 4.93e-9 Migraine; CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg03582286 chr4:71571171 RUFY3 0.43 6.9 0.36 2.74e-11 Obesity-related traits; CRC cis rs3771570 1.000 rs60209440 chr2:242260340 G/C cg21155796 chr2:242212141 HDLBP 0.64 6.97 0.36 1.72e-11 Prostate cancer; CRC cis rs10791323 0.572 rs4412766 chr11:133742811 A/C cg15485101 chr11:133734466 NA 0.47 8.09 0.41 1.2e-14 Childhood ear infection; CRC cis rs2019137 0.539 rs6755040 chr2:113981137 T/C cg17445212 chr2:113993313 PAX8;LOC440839;LOC654433 0.47 7.3 0.37 2.14e-12 Lymphocyte counts; CRC cis rs6496044 0.568 rs4842888 chr15:86063133 C/T cg17133734 chr15:86042851 AKAP13 -0.41 -6.87 -0.35 3.2e-11 Interstitial lung disease; CRC cis rs7831492 0.548 rs10958699 chr8:41648358 C/T cg12180191 chr8:41686706 ANK1 -0.37 -5.74 -0.3 2.13e-8 Colorectal cancer; CRC cis rs12745968 0.623 rs10874732 chr1:93123559 A/T cg17283838 chr1:93427260 FAM69A -0.45 -6.14 -0.32 2.34e-9 Bipolar disorder and schizophrenia; CRC cis rs561341 0.769 rs12941700 chr17:30185022 A/G cg19193384 chr17:30244184 NA 0.49 5.69 0.3 2.78e-8 Hip circumference adjusted for BMI; CRC cis rs59918340 0.692 rs6983780 chr8:142231944 G/A cg23750338 chr8:142222470 SLC45A4 0.6 11.05 0.52 2.29e-24 Immature fraction of reticulocytes; CRC cis rs11098499 0.909 rs35111518 chr4:120440682 A/G cg24375607 chr4:120327624 NA 0.47 7.13 0.37 6.55e-12 Corneal astigmatism; CRC cis rs40363 0.729 rs6501176 chr16:3522197 A/G cg05754148 chr16:3507555 NAT15 -0.62 -7.39 -0.38 1.21e-12 Tuberculosis; CRC cis rs798554 0.642 rs2533871 chr7:2883006 C/G cg19346786 chr7:2764209 NA -0.39 -6.61 -0.34 1.6e-10 Height; CRC cis rs12410462 0.681 rs4486420 chr1:227572321 T/A cg04117972 chr1:227635322 NA 0.67 6.22 0.32 1.54e-9 Major depressive disorder; CRC cis rs6424115 0.830 rs2501425 chr1:24199339 A/C cg09473613 chr1:24152604 HMGCL 0.35 5.66 0.3 3.35e-8 Immature fraction of reticulocytes; CRC cis rs17270561 0.887 rs717551 chr6:25855624 T/C cg17691542 chr6:26056736 HIST1H1C 0.82 9.3 0.46 2.04e-18 Iron status biomarkers; CRC trans rs1890645 0.962 rs10921865 chr1:195524821 T/C cg13026754 chr14:94392718 FAM181A;C14orf86 -0.38 -5.99 -0.31 5.4e-9 Neonatal lupus; CRC trans rs208520 0.526 rs4710310 chr6:66802808 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.18 -25.41 -0.81 1.42e-79 Exhaled nitric oxide output; CRC cis rs73001065 0.901 rs10401969 chr19:19407718 A/G cg03709012 chr19:19516395 GATAD2A 0.83 6.35 0.33 7.24e-10 LDL cholesterol; CRC cis rs72627123 0.737 rs61475846 chr14:74485781 T/C cg12022184 chr14:74485813 ENTPD5;C14orf45 0.72 6.19 0.32 1.8e-9 Morning vs. evening chronotype; CRC trans rs6703335 0.870 rs10803142 chr1:243598234 A/G cg13425515 chr18:2571394 NDC80;METTL4 0.44 6.14 0.32 2.37e-9 Schizophrenia;Schizophrenia, schizoaffective disorder or bipolar disorder; CRC cis rs514406 0.893 rs476108 chr1:53317351 C/T cg25767906 chr1:53392781 SCP2 -0.45 -7.35 -0.38 1.54e-12 Monocyte count; CRC cis rs7647973 0.925 rs6808036 chr3:49236439 T/G cg07636037 chr3:49044803 WDR6 0.64 7.89 0.4 4.38e-14 Menarche (age at onset); CRC cis rs7264396 0.563 rs3827029 chr20:34332784 G/T cg04508476 chr20:34239394 CPNE1;RBM12 0.42 6.26 0.33 1.2e-9 Total cholesterol levels; CRC cis rs10464366 0.571 rs4723825 chr7:39157627 G/C cg20302533 chr7:39170763 POU6F2 0.42 5.7 0.3 2.74e-8 IgG glycosylation; CRC cis rs7833986 0.501 rs2719233 chr8:56886156 A/G cg23139584 chr8:56987506 RPS20;SNORD54 0.78 10.14 0.49 3.28e-21 Height; CRC cis rs4689388 0.890 rs4688991 chr4:6302220 C/G cg25554036 chr4:6271136 WFS1 0.52 8.47 0.42 8.39e-16 Type 2 diabetes and other traits;Type 2 diabetes; CRC cis rs972578 0.905 rs738396 chr22:43370791 G/A cg01576275 chr22:43409880 NA -0.45 -7.3 -0.37 2.13e-12 Mean platelet volume; CRC cis rs362272 0.524 rs10937924 chr4:3374898 T/C cg16416165 chr4:3325029 RGS12 0.4 5.99 0.31 5.54e-9 Serum sulfate level; CRC cis rs9302635 0.513 rs13334151 chr16:72189727 A/C cg23815491 chr16:72088622 HP 0.62 7.88 0.4 4.91e-14 Blood protein levels; CRC cis rs4964805 0.710 rs1866296 chr12:104187092 G/A cg02344784 chr12:104178138 NT5DC3 0.79 15.03 0.64 3.07e-39 Attention deficit hyperactivity disorder; CRC trans rs6076960 0.682 rs6054065 chr20:6267920 G/A cg17788362 chr6:86352627 SYNCRIP 0.49 6.89 0.36 2.79e-11 Smooth-surface caries; CRC cis rs713587 0.713 rs11682135 chr2:25205377 G/A cg04586622 chr2:25135609 ADCY3 0.36 6.09 0.32 3.16e-9 Body mass index in non-asthmatics; CRC cis rs1011108 1.000 rs1011108 chr2:26782621 A/G cg26900154 chr2:26781731 OTOF -0.42 -6.53 -0.34 2.49e-10 Periodontal microbiota; CRC cis rs1218582 0.774 rs4845680 chr1:154863195 A/G cg24250549 chr1:154909240 PMVK 0.64 10.87 0.51 1.02e-23 Prostate cancer; CRC trans rs916888 0.697 rs199516 chr17:44856485 C/T cg23590916 chr17:43697445 MGC57346 -0.57 -6.14 -0.32 2.41e-9 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs6502050 0.835 rs9911379 chr17:80114529 A/G cg22110888 chr17:80059540 CCDC57 0.42 6.74 0.35 7.04e-11 Life satisfaction; CRC cis rs9399137 0.561 rs11753985 chr6:135280438 C/T cg24558204 chr6:135376177 HBS1L 0.6 8.75 0.43 1.1e-16 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; CRC cis rs644799 0.526 rs542509 chr11:95641602 A/G cg25622487 chr11:95524042 FAM76B;CEP57 0.5 7.42 0.38 1.01e-12 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs9914988 0.778 rs4794837 chr17:27110024 T/C cg12682573 chr17:27188876 MIR451;MIR144 0.58 7.99 0.4 2.37e-14 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC trans rs2303319 0.504 rs55840249 chr2:162426849 C/A cg18122310 chr12:50236657 BCDIN3D -0.72 -6.06 -0.32 3.68e-9 Cognitive function; CRC cis rs2991971 0.967 rs644915 chr1:46007002 T/C cg15605315 chr1:45957053 TESK2 0.43 6.95 0.36 2.01e-11 High light scatter reticulocyte count; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg25978167 chr4:57301353 PAICS;PPAT 0.5 6.45 0.34 4.01e-10 Thyroid stimulating hormone; CRC cis rs8072100 0.544 rs7214993 chr17:45386797 C/G cg08085267 chr17:45401833 C17orf57 -0.6 -9.35 -0.46 1.35e-18 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs10992471 0.528 rs7860786 chr9:95245473 C/T cg14631576 chr9:95140430 CENPP -0.35 -6.46 -0.34 3.8e-10 Visceral adipose tissue/subcutaneous adipose tissue ratio; CRC cis rs62458065 0.513 rs10268803 chr7:32547835 A/G cg20159608 chr7:32802032 NA -0.62 -7.81 -0.4 7.87e-14 Metabolite levels (HVA/MHPG ratio); CRC cis rs6502050 0.835 rs7503111 chr17:80101587 A/T cg25804541 chr17:80189381 SLC16A3 -0.31 -5.97 -0.31 6.08e-9 Life satisfaction; CRC cis rs7615952 0.599 rs1044215 chr3:125725559 C/G cg18479299 chr3:125709523 NA -0.49 -6.44 -0.33 4.17e-10 Blood pressure (smoking interaction); CRC cis rs1862618 0.802 rs2591949 chr5:56132627 T/C cg24531977 chr5:56204891 C5orf35 -0.81 -10.94 -0.52 5.99e-24 Initial pursuit acceleration; CRC cis rs977987 0.806 rs12917651 chr16:75466696 G/T cg03315344 chr16:75512273 CHST6 0.55 9.12 0.45 7.56e-18 Dupuytren's disease; CRC cis rs2235544 0.664 rs41366847 chr1:54476967 C/G cg25741118 chr1:54482237 LDLRAD1 -0.22 -5.98 -0.31 5.9e-9 Multiple myeloma (hyperdiploidy);Thyroid hormone levels; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg06100147 chr7:143059260 FAM131B 0.37 6.29 0.33 1.02e-9 Liver disease severity in Alagille syndrome; CRC cis rs739401 0.611 rs2071104 chr11:3036933 G/T cg25174290 chr11:3078921 CARS 0.47 7.35 0.38 1.55e-12 Longevity; CRC cis rs2204008 0.580 rs1315373 chr12:38179114 T/G cg26384229 chr12:38710491 ALG10B -0.58 -8.61 -0.43 3.12e-16 Bladder cancer; CRC cis rs1670533 1.000 rs6599278 chr4:1058798 C/T cg27284194 chr4:1044797 NA 0.51 6.24 0.33 1.35e-9 Recombination rate (females); CRC cis rs992157 0.798 rs12053514 chr2:219167965 C/T cg00012203 chr2:219082015 ARPC2 -0.49 -7.25 -0.37 2.99e-12 Colorectal cancer; CRC cis rs11764590 0.671 rs62444906 chr7:2083161 G/T cg02825527 chr7:2087843 MAD1L1 -0.5 -6.02 -0.32 4.61e-9 Neuroticism; CRC cis rs8062405 0.755 rs4787456 chr16:28559573 C/T cg05139728 chr16:28306816 SBK1 -0.37 -5.99 -0.31 5.4e-9 Cognitive ability (multi-trait analysis);Cognitive ability; CRC cis rs6933660 0.646 rs6911456 chr6:151778934 A/G cg17179660 chr6:151773299 C6orf211;RMND1 -0.41 -6.16 -0.32 2.07e-9 Menarche (age at onset); CRC cis rs798554 0.679 rs2527681 chr7:2892384 A/T cg19717773 chr7:2847554 GNA12 -0.46 -6.66 -0.34 1.18e-10 Height; CRC cis rs6545883 0.929 rs13413337 chr2:61747123 A/G cg15711740 chr2:61764176 XPO1 -0.49 -6.74 -0.35 6.9e-11 Tuberculosis; CRC trans rs7142881 0.604 rs6571468 chr14:32288862 G/A cg07250515 chr12:56618133 OBFC2B 0.39 6.06 0.32 3.65e-9 Response to iloperidone treatment (QT prolongation); CRC cis rs9487051 0.676 rs6929438 chr6:109595506 C/T cg12927641 chr6:109611667 NA -0.35 -6.24 -0.33 1.33e-9 Reticulocyte fraction of red cells; CRC cis rs9911578 0.967 rs6503893 chr17:57149695 G/A cg12560992 chr17:57184187 TRIM37 0.94 17.88 0.7 2e-50 Intelligence (multi-trait analysis); CRC cis rs9322193 0.923 rs4869750 chr6:150177132 C/T cg07701084 chr6:150067640 NUP43 0.45 6.49 0.34 3.23e-10 Lung cancer; CRC cis rs13118159 1.000 rs13118159 chr4:1365127 A/G cg19318889 chr4:1322082 MAEA 0.41 5.72 0.3 2.36e-8 Longevity; CRC cis rs7712401 0.525 rs193541 chr5:122253304 C/T cg18764291 chr5:122110994 SNX2 0.41 6.47 0.34 3.6e-10 Mean platelet volume; CRC cis rs801193 1.000 rs2659906 chr7:66165310 T/C cg05627663 chr7:65219948 SNORA22;CCT6P1 0.43 6.27 0.33 1.13e-9 Aortic root size; CRC cis rs9611565 0.729 rs73176689 chr22:41782633 T/C cg06481639 chr22:41940642 POLR3H -0.51 -5.73 -0.3 2.25e-8 Vitiligo; CRC cis rs1904096 0.506 rs6532476 chr4:95192461 C/A cg11021082 chr4:95130006 SMARCAD1 -0.59 -9.42 -0.46 8.47e-19 Type 2 diabetes; CRC cis rs2279817 1.000 rs35148872 chr1:18020184 G/A cg21791023 chr1:18019539 ARHGEF10L -0.5 -5.64 -0.3 3.57e-8 Neuroticism; CRC cis rs16852403 0.548 rs10798601 chr1:178186881 C/T cg00404053 chr1:178313656 RASAL2 0.49 6.47 0.34 3.64e-10 Childhood ear infection; CRC cis rs4332037 0.539 rs56305291 chr7:2048706 A/G cg23378565 chr7:2036160 MAD1L1 -0.48 -6.66 -0.34 1.13e-10 Bipolar disorder; CRC cis rs7647973 0.626 rs7649428 chr3:49868876 A/T cg03060546 chr3:49711283 APEH -0.66 -7.73 -0.39 1.28e-13 Menarche (age at onset); CRC cis rs4713118 0.513 rs183244 chr6:28031838 C/A cg06470822 chr6:28175283 NA 0.82 12.11 0.56 3.71e-28 Parkinson's disease; CRC cis rs1816752 0.905 rs6490927 chr13:25013940 C/G cg02811702 chr13:24901961 NA 0.47 6.55 0.34 2.16e-10 Obesity-related traits; CRC cis rs11719291 0.833 rs73080361 chr3:48832146 G/A cg07636037 chr3:49044803 WDR6 -0.85 -6.05 -0.32 3.86e-9 Cognitive function; CRC cis rs9322193 0.962 rs9397357 chr6:150133601 G/A cg05861140 chr6:150128134 PCMT1 -0.41 -6.58 -0.34 1.8e-10 Lung cancer; CRC cis rs7692995 1.000 rs11930105 chr4:17972078 C/A cg08925142 chr4:18023851 LCORL -0.51 -5.68 -0.3 3.03e-8 Height; CRC cis rs853679 0.517 rs9295758 chr6:28120663 C/G cg12963246 chr6:28129442 ZNF389 0.49 5.7 0.3 2.71e-8 Depression; CRC cis rs11166629 1.000 rs966659 chr8:135639045 C/T cg27224718 chr8:135614730 ZFAT -0.5 -7.39 -0.38 1.24e-12 Smoking quantity; CRC cis rs10870270 1.000 rs7077744 chr10:133770201 C/T cg08754478 chr10:133766260 PPP2R2D -0.66 -9.29 -0.46 2.22e-18 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; CRC trans rs703108 0.731 rs7898954 chr10:22323646 A/G cg19427701 chr9:140196790 NRARP -0.5 -6.0 -0.31 5.31e-9 Monocyte percentage of white cells; CRC cis rs4713118 0.955 rs9380011 chr6:27683924 A/G cg26587870 chr6:27730563 NA -0.42 -6.28 -0.33 1.05e-9 Parkinson's disease; CRC cis rs860295 0.836 rs1360554 chr1:155473356 C/T cg02153340 chr1:155202674 NA 0.43 5.62 0.3 4.03e-8 Body mass index; CRC cis rs9487051 0.872 rs4601178 chr6:109611246 C/T cg12927641 chr6:109611667 NA -0.38 -6.94 -0.36 2.15e-11 Reticulocyte fraction of red cells; CRC cis rs896854 0.552 rs2515236 chr8:95934907 A/G cg16049864 chr8:95962084 TP53INP1 0.53 8.26 0.41 3.55e-15 Type 2 diabetes; CRC cis rs2243480 1.000 rs2465120 chr7:65620974 C/G cg25985355 chr7:65971099 NA -0.53 -6.05 -0.32 3.9e-9 Diabetic kidney disease; CRC cis rs9322193 0.886 rs17672976 chr6:150097343 T/A cg00933542 chr6:150070202 PCMT1 0.28 5.63 0.3 3.86e-8 Lung cancer; CRC cis rs12024301 0.557 rs12088165 chr1:183658099 C/T cg11505048 chr1:183622726 RGL1;APOBEC4 0.68 5.86 0.31 1.13e-8 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs13118159 0.836 rs2293630 chr4:1342521 G/A cg24560729 chr4:1342394 KIAA1530 0.46 8.38 0.42 1.59e-15 Longevity; CRC cis rs1863824 0.625 rs10887600 chr10:88169072 C/T cg07322936 chr10:88137208 NA -0.64 -8.66 -0.43 2.11e-16 Schizophrenia; CRC cis rs6502050 0.835 rs4789670 chr17:80151805 T/C cg13198984 chr17:80129470 CCDC57 0.44 7.82 0.4 7.02e-14 Life satisfaction; CRC cis rs12760731 0.623 rs12239670 chr1:178377761 G/T cg00404053 chr1:178313656 RASAL2 0.72 8.86 0.44 4.95e-17 Obesity-related traits; CRC cis rs425277 0.583 rs3107151 chr1:2051513 T/G cg12639453 chr1:2035780 PRKCZ -0.38 -7.12 -0.37 6.62e-12 Height; CRC cis rs798554 0.757 rs1182172 chr7:2878103 G/A cg17321639 chr7:2759063 NA -0.53 -6.98 -0.36 1.68e-11 Height; CRC cis rs1572438 1.000 rs9379167 chr6:866372 C/T cg21062780 chr6:887772 NA -0.43 -6.5 -0.34 3.04e-10 Aging; CRC cis rs4713118 0.662 rs149947 chr6:27972433 A/T cg02683197 chr6:28174875 NA 0.71 9.58 0.47 2.43e-19 Parkinson's disease; CRC trans rs2014572 0.967 rs8111977 chr19:57759158 T/A cg02674126 chr19:40336878 FBL 0.42 6.69 0.35 9.58e-11 Hyperactive-impulsive symptoms; CRC cis rs1697139 0.583 rs11960733 chr5:66538715 C/T cg16691251 chr5:66510806 NA 0.41 7.08 0.36 8.67e-12 Breast cancer; CRC cis rs4713118 0.527 rs9461433 chr6:28095172 C/T cg12963246 chr6:28129442 ZNF389 0.49 5.78 0.3 1.73e-8 Parkinson's disease; CRC cis rs9660992 0.674 rs56198325 chr1:205265450 G/A cg21643547 chr1:205240462 TMCC2 -0.45 -7.19 -0.37 4.43e-12 Mean corpuscular volume;Mean platelet volume; CRC cis rs10504229 0.654 rs903705 chr8:58128185 T/A cg24829409 chr8:58192753 C8orf71 -0.55 -8.03 -0.4 1.71e-14 Developmental language disorder (linguistic errors); CRC cis rs1448094 0.717 rs7298614 chr12:86296513 C/T cg02569458 chr12:86230093 RASSF9 0.37 6.12 0.32 2.69e-9 Major depressive disorder; CRC cis rs7945705 0.902 rs2016942 chr11:8938787 A/G cg12365402 chr11:9010492 NRIP3 0.48 7.8 0.39 8.4e-14 Hemoglobin concentration; CRC cis rs7586879 0.828 rs9631061 chr2:25109804 C/T cg04586622 chr2:25135609 ADCY3 -0.58 -9.88 -0.48 2.45e-20 Body mass index; CRC cis rs7666738 0.830 rs13148363 chr4:98847498 T/C cg05340658 chr4:99064831 C4orf37 0.55 8.06 0.41 1.38e-14 Colonoscopy-negative controls vs population controls; CRC cis rs3749237 0.595 rs4855859 chr3:49526300 C/T cg02487422 chr3:49467188 NICN1 0.43 6.91 0.36 2.5e-11 Resting heart rate; CRC cis rs9926296 0.605 rs8047486 chr16:89854025 A/T cg03388025 chr16:89894329 SPIRE2 0.4 7.84 0.4 6.28e-14 Vitiligo; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg17009717 chr2:113299708 POLR1B 0.44 6.17 0.32 2.03e-9 Response to antipsychotic treatment; CRC trans rs1455244 0.700 rs7229302 chr18:11508904 G/T cg24677732 chr10:6019526 IL15RA 0.42 6.61 0.34 1.53e-10 Schizophrenia; CRC cis rs7584330 0.744 rs10929234 chr2:238380034 C/G cg16989719 chr2:238392110 NA 0.46 7.84 0.4 6.16e-14 Prostate cancer; CRC cis rs13118159 0.573 rs7664763 chr4:1352305 A/G cg02475777 chr4:1388615 CRIPAK 0.54 6.92 0.36 2.34e-11 Longevity; CRC cis rs6502050 0.865 rs8073679 chr17:80155343 G/A cg19223190 chr17:80058835 NA 0.41 6.49 0.34 3.13e-10 Life satisfaction; CRC cis rs9916302 0.851 rs612209 chr17:37442713 G/C cg03013999 chr17:37608204 MED1 -0.49 -7.62 -0.39 2.81e-13 Glomerular filtration rate (creatinine); CRC cis rs6756513 0.509 rs11686934 chr2:70172116 C/T cg02498382 chr2:70120550 SNRNP27 0.41 6.89 0.36 2.86e-11 Breast cancer;Platelet count; CRC cis rs9462027 0.628 rs9469887 chr6:34758940 C/T cg07306190 chr6:34760872 UHRF1BP1 -0.35 -6.23 -0.33 1.4e-9 Systemic lupus erythematosus; CRC cis rs274567 0.602 rs272853 chr5:131688561 A/G cg09877947 chr5:131593287 PDLIM4 0.41 6.95 0.36 1.97e-11 Blood metabolite levels; CRC cis rs751837 0.591 rs2896462 chr14:103434739 A/G cg10087771 chr14:103399429 CDC42BPB 0.65 6.28 0.33 1.06e-9 Large B-cell lymphoma; CRC cis rs13191362 1.000 rs66789102 chr6:163104432 T/C cg06582575 chr6:163149167 PACRG;PARK2 0.93 11.84 0.55 3.6e-27 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs870825 0.929 rs72689278 chr4:185593718 C/T cg04058563 chr4:185651563 MLF1IP 0.74 7.5 0.38 5.81e-13 Blood protein levels; CRC trans rs3960554 0.740 rs10216079 chr7:75690988 A/C cg19862616 chr7:65841803 NCRNA00174 0.73 8.65 0.43 2.23e-16 Eotaxin levels; CRC trans rs9329221 0.527 rs34308302 chr8:10332022 C/T cg16141378 chr3:129829833 LOC729375 0.41 6.05 0.32 3.87e-9 Neuroticism; CRC cis rs9311474 1.000 rs7629072 chr3:52305633 C/T cg15147215 chr3:52552868 STAB1 -0.65 -11.37 -0.53 1.78e-25 Electroencephalogram traits; CRC cis rs57221529 0.600 rs11750269 chr5:666270 G/A cg14541582 chr5:601475 NA -0.35 -6.43 -0.33 4.48e-10 Lung disease severity in cystic fibrosis; CRC cis rs1552244 0.882 rs13099136 chr3:10031431 G/A cg00166722 chr3:10149974 C3orf24 0.61 8.0 0.4 2.15e-14 Alzheimer's disease; CRC cis rs2836974 0.899 rs2836957 chr21:40623134 T/C cg17971929 chr21:40555470 PSMG1 0.84 12.0 0.55 9.21e-28 Cognitive function; CRC cis rs9486719 0.895 rs3734238 chr6:96996228 A/T cg18709589 chr6:96969512 KIAA0776 -0.53 -5.98 -0.31 5.81e-9 Migraine;Coronary artery disease; CRC cis rs13064411 0.696 rs7631082 chr3:113208913 C/G cg18753928 chr3:113234510 CCDC52 -0.7 -10.83 -0.51 1.45e-23 Response to simvastatin treatment (PCSK9 protein level change); CRC cis rs7635838 0.859 rs6768611 chr3:11434465 G/A cg00170343 chr3:11313890 ATG7 0.38 5.67 0.3 3.05e-8 HDL cholesterol; CRC cis rs10504229 0.728 rs72650867 chr8:58154912 C/T cg08219700 chr8:58056026 NA 0.45 5.74 0.3 2.11e-8 Developmental language disorder (linguistic errors); CRC cis rs6694672 0.764 rs1415217 chr1:197151246 C/T cg13682187 chr1:196946512 CFHR5 0.43 6.94 0.36 2.09e-11 Asthma; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg22836370 chr18:51751085 MBD2 0.49 7.11 0.36 7.39e-12 Response to antipsychotic treatment; CRC cis rs9837602 1.000 rs6806178 chr3:99780393 A/C cg07805332 chr3:99536008 MIR548G;C3orf26 -0.51 -6.9 -0.36 2.6e-11 Breast cancer; CRC cis rs4638749 0.677 rs7568919 chr2:108832376 C/A cg25838818 chr2:108905173 SULT1C2 -0.34 -5.75 -0.3 2.01e-8 Blood pressure; CRC trans rs637571 0.780 rs677029 chr11:65683531 A/G cg17712092 chr4:129076599 LARP1B 0.94 17.44 0.69 1.11e-48 Eosinophil percentage of white cells; CRC trans rs800082 0.668 rs6805395 chr3:144292116 T/C cg24215973 chr2:240111563 HDAC4 -0.64 -10.19 -0.49 2.22e-21 Smoking behavior; CRC cis rs7943191 0.810 rs7942154 chr11:62337163 G/A cg02600515 chr11:62521696 ZBTB3 0.46 5.63 0.3 3.88e-8 Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction); CRC cis rs17711722 0.740 rs7809991 chr7:65406218 A/G cg11764359 chr7:65958608 NA 0.5 7.63 0.39 2.58e-13 Calcium levels; CRC cis rs1656402 0.834 rs11676437 chr2:233453065 A/G cg03852847 chr2:233439513 NA -0.42 -7.26 -0.37 2.83e-12 Non-small cell lung cancer (survival); CRC cis rs2075371 1.000 rs1868783 chr7:133975087 A/G cg11752832 chr7:134001865 SLC35B4 0.48 7.44 0.38 8.76e-13 Mean platelet volume; CRC cis rs2739330 0.828 rs5760108 chr22:24252668 G/T cg11905131 chr22:24372483 LOC391322 -0.72 -11.54 -0.54 4.27e-26 Liver enzyme levels (gamma-glutamyl transferase); CRC trans rs11650494 0.908 rs79768864 chr17:47446968 C/A cg11430096 chr6:110968061 CDK19 0.68 5.97 0.31 5.99e-9 Prostate cancer; CRC cis rs10504229 0.610 rs6993531 chr8:58147283 A/G cg21724239 chr8:58056113 NA 0.42 6.13 0.32 2.46e-9 Developmental language disorder (linguistic errors); CRC cis rs9549328 0.837 rs9549618 chr13:113628648 G/A cg20742385 chr13:113633654 MCF2L -0.71 -12.48 -0.57 1.53e-29 Systolic blood pressure; CRC cis rs2839186 0.814 rs2839167 chr21:47661587 A/G cg13012494 chr21:47604986 C21orf56 0.44 6.99 0.36 1.58e-11 Testicular germ cell tumor; CRC cis rs7020830 0.522 rs10814509 chr9:37111057 A/G cg14294708 chr9:37120828 ZCCHC7 0.78 13.71 0.6 3.83e-34 Schizophrenia; CRC cis rs17155006 0.746 rs435744 chr7:107748549 A/G cg05962710 chr7:107745446 LAMB4 -0.41 -7.44 -0.38 8.61e-13 Pneumococcal bacteremia; CRC cis rs853679 0.517 rs4713148 chr6:28115921 G/A cg18032046 chr6:28092343 ZSCAN16 -0.51 -5.93 -0.31 7.47e-9 Depression; CRC cis rs6735179 0.798 rs7589077 chr2:1773183 C/T cg19300414 chr2:1746591 PXDN 0.38 5.85 0.31 1.21e-8 Response to antipsychotic treatment; CRC cis rs11212617 0.967 rs6589019 chr11:108324961 T/C cg12106634 chr11:108092400 ATM;NPAT 0.39 5.67 0.3 3.17e-8 Response to metformin in type 2 diabetes (glycemic); CRC cis rs853679 0.517 rs9368558 chr6:28133306 A/G cg23161317 chr6:28129485 ZNF389 0.53 6.43 0.33 4.52e-10 Depression; CRC cis rs7927771 0.864 rs3781626 chr11:47442893 A/T cg05585544 chr11:47624801 NA -0.47 -8.53 -0.43 5.42e-16 Subjective well-being; CRC cis rs7666738 0.830 rs28619044 chr4:98789814 G/C cg17366294 chr4:99064904 C4orf37 0.42 6.87 0.35 3.3e-11 Colonoscopy-negative controls vs population controls; CRC cis rs7615952 0.599 rs6803160 chr3:125709554 G/T cg02772935 chr3:125709198 NA -0.49 -5.79 -0.3 1.61e-8 Blood pressure (smoking interaction); CRC cis rs2952156 0.920 rs12150298 chr17:37834541 T/C cg11212589 chr17:38028394 ZPBP2 0.35 6.15 0.32 2.26e-9 Asthma; CRC trans rs11343 0.675 rs7359333 chr16:19262344 A/T cg19960548 chr20:49407443 NA -0.51 -6.85 -0.35 3.66e-11 Parkinson's disease; CRC cis rs2882667 0.898 rs3828600 chr5:138386859 G/T cg04439458 chr5:138467593 SIL1 -0.32 -5.74 -0.3 2.18e-8 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs752010 0.714 rs7552928 chr1:42086664 C/T cg06885757 chr1:42089581 HIVEP3 0.51 9.11 0.45 8.4e-18 Lupus nephritis in systemic lupus erythematosus; CRC cis rs11123170 0.640 rs931472 chr2:113969948 C/T cg21610815 chr2:113994035 PAX8;LOC654433;LOC440839 -0.48 -6.36 -0.33 6.79e-10 Renal function-related traits (BUN); CRC trans rs6561151 0.681 rs61209988 chr13:44416335 G/C cg17145862 chr1:211918768 LPGAT1 0.49 6.4 0.33 5.47e-10 Crohn's disease; CRC cis rs7762018 1.000 rs6459657 chr6:170136454 A/G cg17545662 chr6:170176663 C6orf70 0.57 6.4 0.33 5.21e-10 Thiazide-induced adverse metabolic effects in hypertensive patients; CRC cis rs1799949 1.000 rs8176220 chr17:41222462 A/G cg01879757 chr17:41196368 BRCA1 -0.43 -6.53 -0.34 2.56e-10 Menopause (age at onset); CRC cis rs13108904 0.650 rs3796618 chr4:1349602 T/A cg16405210 chr4:1374714 KIAA1530 -0.58 -8.67 -0.43 2e-16 Obesity-related traits; CRC cis rs10744422 1.000 rs7139055 chr12:123364198 A/G cg25930673 chr12:123319894 HIP1R 0.7 7.19 0.37 4.26e-12 Schizophrenia; CRC cis rs3858526 0.508 rs10838734 chr11:5876325 T/G cg26762873 chr11:5879799 OR52E8 -0.5 -7.71 -0.39 1.48e-13 DNA methylation (variation); CRC trans rs2261181 0.711 rs111477823 chr12:66279822 C/A cg01001314 chr4:3669900 NA 0.7 6.09 0.32 3.18e-9 Type 2 diabetes; CRC trans rs2303319 0.504 rs62189054 chr2:162624654 C/G cg23247704 chr1:116518985 SLC22A15 -0.72 -6.12 -0.32 2.7e-9 Cognitive function; CRC cis rs7107174 1.000 rs11237480 chr11:78110385 C/A cg02023728 chr11:77925099 USP35 0.41 6.98 0.36 1.68e-11 Testicular germ cell tumor; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg02771034 chr3:50220121 SEMA3F -0.39 -6.2 -0.32 1.72e-9 Liver disease severity in Alagille syndrome; CRC cis rs847577 0.677 rs4729403 chr7:97707841 G/C cg21770322 chr7:97807741 LMTK2 -0.72 -13.18 -0.59 3.68e-32 Breast cancer; CRC cis rs7178572 0.568 rs10152181 chr15:77678346 A/G cg22256960 chr15:77711686 NA -0.66 -9.6 -0.47 2.13e-19 Type 2 diabetes; CRC cis rs9341808 0.667 rs2490239 chr6:80826289 G/A cg08355045 chr6:80787529 NA 0.39 6.6 0.34 1.64e-10 Sitting height ratio; CRC cis rs7917772 0.503 rs7078435 chr10:104304766 T/C cg11453585 chr10:104263688 ACTR1A;SUFU 0.89 16.6 0.68 2.25e-45 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC trans rs12310956 0.532 rs11052935 chr12:33970946 C/T cg26384229 chr12:38710491 ALG10B 0.47 6.31 0.33 9.14e-10 Morning vs. evening chronotype; CRC cis rs992157 0.585 rs62182795 chr2:219100202 C/T cg04880052 chr2:219191631 PNKD -0.42 -6.64 -0.34 1.3100000000000001e-10 Colorectal cancer; CRC trans rs7618501 0.501 rs35275715 chr3:49959148 A/G cg21659725 chr3:3221576 CRBN 0.47 6.84 0.35 3.98e-11 Intelligence (multi-trait analysis); CRC cis rs875971 0.790 rs10257911 chr7:65743770 A/G cg00343986 chr7:65444356 GUSB -0.45 -6.18 -0.32 1.85e-9 Aortic root size; CRC cis rs7829975 0.514 rs2976929 chr8:8258712 T/C cg06636001 chr8:8085503 FLJ10661 0.65 10.08 0.49 5.25e-21 Mood instability; CRC cis rs11098499 0.779 rs10016060 chr4:120298412 A/G cg09307838 chr4:120376055 NA 0.71 10.93 0.52 6.41e-24 Corneal astigmatism; CRC trans rs875971 0.660 rs2191268 chr7:66110224 C/T cg25227148 chr18:32870611 ZNF271;ZNF397OS -0.4 -6.3 -0.33 9.64e-10 Aortic root size; CRC cis rs873946 0.586 rs12783078 chr10:134569706 C/T cg27286337 chr10:134555280 INPP5A 0.82 9.94 0.48 1.61e-20 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CRC cis rs1552244 0.554 rs17050704 chr3:10045734 T/C cg08888203 chr3:10149979 C3orf24 0.48 7.32 0.37 1.9e-12 Alzheimer's disease; CRC cis rs9322193 0.923 rs4869812 chr6:149990583 A/G cg05861140 chr6:150128134 PCMT1 -0.37 -5.92 -0.31 8.12e-9 Lung cancer; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg02176770 chr11:73358590 PLEKHB1 0.43 6.0 0.31 5.34e-9 Response to antipsychotic treatment; CRC trans rs2795502 1.000 rs2744092 chr10:43339343 T/C cg06791473 chr12:49259579 RND1 0.61 6.03 0.32 4.5e-9 Blood protein levels; CRC cis rs262150 0.731 rs2657388 chr7:158763428 A/G cg10570241 chr7:158785291 NA -0.43 -7.68 -0.39 1.88e-13 Facial morphology (factor 20); CRC cis rs889312 0.500 rs11960484 chr5:56109154 C/T cg03609598 chr5:56110824 MAP3K1 0.44 6.26 0.33 1.23e-9 Breast cancer;Breast cancer (early onset); CRC cis rs6684514 1.000 rs10908495 chr1:156263940 T/C cg16558208 chr1:156270281 VHLL 0.56 8.73 0.43 1.29e-16 Mean corpuscular hemoglobin concentration;Glycated hemoglobin levels; CRC cis rs9837602 0.592 rs1606481 chr3:99427552 A/G cg07805332 chr3:99536008 MIR548G;C3orf26 0.41 5.61 0.3 4.35e-8 Breast cancer; CRC cis rs514406 0.893 rs1242326 chr1:53399104 C/A cg08859206 chr1:53392774 SCP2 -0.48 -7.53 -0.38 4.86e-13 Monocyte count; CRC cis rs79839061 0.656 rs28662837 chr4:879776 G/A cg14530993 chr4:882597 GAK 0.78 7.94 0.4 3.29e-14 Intelligence (multi-trait analysis); CRC trans rs7267979 0.966 rs2227890 chr20:25260931 A/G cg17903999 chr18:56338584 MALT1 -0.41 -6.76 -0.35 6.14e-11 Liver enzyme levels (alkaline phosphatase); CRC cis rs9814567 1.000 rs6800862 chr3:134228628 A/G cg06541857 chr3:134203789 ANAPC13;CEP63 -0.38 -5.76 -0.3 1.95e-8 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs2070997 0.702 rs7457 chr9:133762826 C/T cg01000188 chr9:133769184 QRFP 0.56 5.74 0.3 2.15e-8 Response to amphetamines; CRC cis rs1552244 1.000 rs7637888 chr3:10080722 T/C cg16606324 chr3:10149918 C3orf24 0.73 9.77 0.47 5.73e-20 Alzheimer's disease; CRC trans rs2303319 0.504 rs56260047 chr2:162497225 G/T cg04269497 chr6:167369491 RNASET2 -0.71 -6.01 -0.31 4.99e-9 Cognitive function; CRC cis rs73001065 0.551 rs56397647 chr19:19642795 C/T cg03709012 chr19:19516395 GATAD2A 0.83 6.96 0.36 1.8e-11 LDL cholesterol; CRC cis rs4713118 0.955 rs9468204 chr6:27688809 C/T cg12273811 chr6:28175739 NA 0.5 6.85 0.35 3.68e-11 Parkinson's disease; CRC cis rs6912958 0.558 rs9444530 chr6:88343318 C/T cg08069147 chr6:88032118 GJB7;C6orf162 0.54 8.28 0.42 3.15e-15 Monocyte percentage of white cells; CRC cis rs8180040 0.966 rs6792461 chr3:47473168 C/T cg10298567 chr3:47292165 KIF9 0.38 6.03 0.32 4.42e-9 Colorectal cancer; CRC cis rs11098699 0.821 rs11098703 chr4:124218462 C/G cg09941581 chr4:124220074 SPATA5 0.43 6.36 0.33 6.83e-10 Mosquito bite size; CRC cis rs6963495 0.818 rs6977748 chr7:105167462 T/G cg13798780 chr7:105162888 PUS7 0.66 7.8 0.39 8.45e-14 Bipolar disorder (body mass index interaction); CRC cis rs4654899 0.931 rs3125161 chr1:21126346 A/G cg02927042 chr1:21476669 EIF4G3 0.45 7.12 0.37 6.64e-12 Superior frontal gyrus grey matter volume; CRC cis rs6089584 0.927 rs3787427 chr20:60579789 T/C cg18761221 chr20:60518478 NA 0.39 6.87 0.35 3.19e-11 Body mass index; CRC cis rs4144743 1.000 rs4144744 chr17:45323262 A/G cg18085866 chr17:45331354 ITGB3 -0.59 -8.11 -0.41 1.02e-14 Body mass index; CRC cis rs9942416 0.660 rs10462356 chr5:74987108 C/T cg00601450 chr5:74908170 NA 0.41 5.76 0.3 1.95e-8 Age-related disease endophenotypes; CRC cis rs12802200 0.561 rs746707 chr11:571984 C/T cg09218773 chr11:619014 MUPCDH -0.36 -5.79 -0.3 1.64e-8 Systemic lupus erythematosus; CRC cis rs4664293 0.967 rs7595639 chr2:160533044 A/G cg08347373 chr2:160653686 CD302 -0.37 -6.08 -0.32 3.32e-9 Monocyte percentage of white cells; CRC cis rs10131894 0.635 rs174997 chr14:75434806 G/A cg08847533 chr14:75593920 NEK9 -0.7 -11.06 -0.52 2.17e-24 Coronary artery disease; CRC cis rs9648716 1.000 rs1267648 chr7:140505100 A/G cg10747023 chr7:140774559 NA 0.42 5.64 0.3 3.63e-8 Type 2 diabetes; CRC cis rs11077998 0.967 rs12185229 chr17:80499065 G/C cg10255544 chr17:80519551 FOXK2 0.38 5.98 0.31 5.72e-9 Reticulocyte fraction of red cells; CRC cis rs11758351 0.660 rs75156165 chr6:26235699 C/A cg01420254 chr6:26195488 NA 0.72 7.75 0.39 1.18e-13 Gout;Renal underexcretion gout; CRC cis rs6502050 0.835 rs7221544 chr17:80087337 C/T cg13198984 chr17:80129470 CCDC57 -0.46 -7.99 -0.4 2.24e-14 Life satisfaction; CRC cis rs10504229 0.683 rs11786845 chr8:58133642 T/C cg22535103 chr8:58192502 C8orf71 -0.69 -9.14 -0.45 6.55e-18 Developmental language disorder (linguistic errors); CRC cis rs12701220 0.542 rs6957866 chr7:1111674 G/A cg00990874 chr7:1149470 C7orf50 -0.5 -5.86 -0.31 1.13e-8 Bronchopulmonary dysplasia; CRC cis rs67478160 0.575 rs8014294 chr14:104322983 A/G cg01849466 chr14:104193079 ZFYVE21 -0.53 -9.5 -0.46 4.56e-19 Schizophrenia; CRC cis rs58688157 0.705 rs12795572 chr11:590999 G/A cg01842473 chr11:617407 IRF7;MUPCDH -0.56 -6.68 -0.35 9.99e-11 Systemic lupus erythematosus; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg18327994 chr9:132372705 NA 0.5 7.16 0.37 5.23e-12 Response to antipsychotic treatment; CRC cis rs28386778 0.863 rs9207 chr17:61823899 C/T cg22520471 chr17:61851767 DDX42;CCDC47 0.74 11.56 0.54 3.69e-26 Prudent dietary pattern; CRC trans rs7201408 0.528 rs12596252 chr16:20056993 G/A cg07180834 chr11:85838833 NA 0.44 6.03 0.32 4.46e-9 Attention deficit hyperactivity disorder (inattention symptoms); CRC cis rs6456156 0.846 rs204293 chr6:167514481 T/C cg05540913 chr6:167530185 CCR6 0.34 5.79 0.3 1.67e-8 Primary biliary cholangitis; CRC cis rs2239547 0.657 rs4687554 chr3:52864135 T/C cg11645453 chr3:52864694 ITIH4 0.61 10.96 0.52 4.76e-24 Schizophrenia; CRC cis rs950027 0.584 rs1145086 chr15:45654327 A/G cg10760299 chr15:45669010 GATM 0.36 5.67 0.3 3.17e-8 Response to fenofibrate (adiponectin levels); CRC cis rs2243480 1.000 rs313824 chr7:65581207 C/T cg18252515 chr7:66147081 NA -1.18 -13.88 -0.61 8.21e-35 Diabetic kidney disease; CRC cis rs950776 0.531 rs12915652 chr15:78831928 G/A cg06917634 chr15:78832804 PSMA4 0.66 10.49 0.5 2.16e-22 Sudden cardiac arrest; CRC cis rs1153858 1.000 rs12101539 chr15:45650666 C/G cg21132104 chr15:45694354 SPATA5L1 0.59 8.67 0.43 1.95e-16 Homoarginine levels; CRC cis rs4481887 0.893 rs4529743 chr1:248473683 G/C cg13385794 chr1:248469461 NA 0.38 6.75 0.35 6.84e-11 Common traits (Other); CRC cis rs853679 0.760 rs11962305 chr6:28199937 G/C cg21251018 chr6:28226885 NKAPL 0.51 5.98 0.31 5.84e-9 Depression; CRC cis rs6502050 0.835 rs7405738 chr17:80084227 A/G cg02741985 chr17:80059408 CCDC57 -0.44 -7.15 -0.37 5.61e-12 Life satisfaction; CRC cis rs2243480 1.000 rs2420171 chr7:65637760 T/C cg12463550 chr7:65579703 CRCP -0.71 -6.52 -0.34 2.61e-10 Diabetic kidney disease; CRC cis rs7208859 0.673 rs12103759 chr17:29235687 G/A cg14008862 chr17:28927542 LRRC37B2 0.56 5.8 0.3 1.6e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs4889855 0.530 rs62068346 chr17:78608052 A/G cg16591659 chr17:78472290 NA -0.43 -6.25 -0.33 1.25e-9 Fractional excretion of uric acid; CRC cis rs938554 0.784 rs1071988 chr4:9974638 A/G cg00071950 chr4:10020882 SLC2A9 -0.45 -6.46 -0.34 3.75e-10 Blood metabolite levels; CRC cis rs853679 0.513 rs9468296 chr6:28113730 A/G cg23161317 chr6:28129485 ZNF389 0.53 6.43 0.33 4.52e-10 Depression; CRC cis rs1580019 0.961 rs1580022 chr7:32497712 C/A cg07520158 chr7:32535189 LSM5;AVL9 0.45 6.48 0.34 3.4e-10 Cognitive ability; CRC cis rs1005277 0.579 rs1780146 chr10:38517874 C/A cg25517755 chr10:38738941 LOC399744 -0.42 -5.98 -0.31 5.66e-9 Extrinsic epigenetic age acceleration; CRC cis rs6681460 0.932 rs523956 chr1:67188276 A/G cg02459107 chr1:67143332 SGIP1 -0.36 -6.04 -0.32 4.21e-9 Presence of antiphospholipid antibodies; CRC cis rs7605827 0.897 rs13004112 chr2:15604048 C/T cg19274914 chr2:15703543 NA 0.39 6.02 0.32 4.65e-9 Educational attainment (years of education); CRC cis rs17253792 0.822 rs117050012 chr14:56038729 G/T cg01858014 chr14:56050164 KTN1 -0.88 -6.83 -0.35 4.04e-11 Putamen volume; CRC cis rs10540 1.000 rs61876340 chr11:495699 A/C cg03352830 chr11:487213 PTDSS2 0.67 7.7 0.39 1.63e-13 Body mass index; CRC cis rs2304069 0.954 rs4705408 chr5:149412545 A/G cg22760475 chr5:149380129 HMGXB3;TIGD6 -0.85 -9.64 -0.47 1.52e-19 HIV-1 control; CRC cis rs875971 0.862 rs6952182 chr7:65683317 T/G cg12463550 chr7:65579703 CRCP -0.5 -6.82 -0.35 4.33e-11 Aortic root size; CRC cis rs4319547 0.915 rs10773208 chr12:122970156 T/C cg23029597 chr12:123009494 RSRC2 -0.61 -7.57 -0.39 3.84e-13 Body mass index; CRC trans rs35110281 0.840 rs2838331 chr21:45026728 A/G cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO -0.51 -8.64 -0.43 2.55e-16 Mean corpuscular volume; CRC cis rs8060686 0.920 rs55661503 chr16:67836552 T/A cg08314208 chr16:67682810 RLTPR -0.65 -7.41 -0.38 1.08e-12 HDL cholesterol;Metabolic syndrome; CRC cis rs11758351 0.866 rs2069018 chr6:26205718 T/C cg10723962 chr6:26240782 HIST1H4F -0.38 -6.0 -0.31 5.06e-9 Gout;Renal underexcretion gout; CRC cis rs1519814 0.956 rs4871036 chr8:121101758 T/C cg22335954 chr8:121166405 COL14A1 -0.54 -6.41 -0.33 5.12e-10 Breast cancer; CRC cis rs853679 0.550 rs1237875 chr6:28173010 A/G cg15786705 chr6:28176104 NA -0.81 -11.55 -0.54 3.79e-26 Depression; CRC cis rs1552244 0.935 rs7618815 chr3:10151045 A/G cg16606324 chr3:10149918 C3orf24 0.73 9.63 0.47 1.7e-19 Alzheimer's disease; CRC cis rs713587 0.563 rs11686663 chr2:25107759 C/T cg04586622 chr2:25135609 ADCY3 -0.56 -10.38 -0.5 4.97e-22 Body mass index in non-asthmatics; CRC cis rs798554 0.797 rs798488 chr7:2802522 T/C cg14863265 chr7:2801509 GNA12 -0.43 -5.93 -0.31 7.56e-9 Height; CRC cis rs4713118 0.621 rs4713133 chr6:28034041 T/C cg15845792 chr6:28175446 NA 0.92 12.48 0.57 1.64e-29 Parkinson's disease; CRC cis rs1577917 0.518 rs6454482 chr6:86418188 G/A cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A 0.57 8.25 0.41 3.81e-15 Response to antipsychotic treatment; CRC cis rs1129187 0.935 rs4987173 chr6:42931224 G/A cg27588902 chr6:42928151 GNMT -0.39 -6.96 -0.36 1.89e-11 Alzheimer's disease in APOE e4+ carriers; CRC cis rs231513 0.911 rs231517 chr17:41961789 C/T cg26893861 chr17:41843967 DUSP3 -0.7 -7.13 -0.37 6.41e-12 Cognitive function; CRC cis rs1552244 1.000 rs6442148 chr3:10078289 G/C cg08888203 chr3:10149979 C3orf24 0.7 10.06 0.49 6.03e-21 Alzheimer's disease; CRC cis rs7917772 0.503 rs56397707 chr10:104302693 T/C cg11453585 chr10:104263688 ACTR1A;SUFU 0.9 16.75 0.68 5.87e-46 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg17829318 chr4:37688612 RELL1 0.4 6.21 0.32 1.6e-9 Response to antipsychotic treatment; CRC cis rs9467711 0.606 rs35076545 chr6:26603924 C/A cg08501292 chr6:25962987 TRIM38 0.88 6.11 0.32 2.84e-9 Autism spectrum disorder or schizophrenia; CRC trans rs4714291 0.748 rs3008829 chr6:39953963 C/T cg02267698 chr19:7991119 CTXN1 -0.48 -6.62 -0.34 1.5e-10 Strep throat; CRC cis rs7301826 0.651 rs7295705 chr12:131301885 C/T cg11011512 chr12:131303247 STX2 0.37 5.61 0.3 4.35e-8 Plasma plasminogen activator levels; CRC cis rs7216064 0.734 rs11653507 chr17:65892064 A/T cg12091567 chr17:66097778 LOC651250 -0.44 -5.74 -0.3 2.13e-8 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CRC cis rs11204677 1 rs11204677 chr1:150574695 C/G cg17724175 chr1:150552817 MCL1 -0.51 -8.1 -0.41 1.12e-14 Monocyte percentage of white cells;Granulocyte percentage of myeloid white cells; CRC cis rs947211 1.000 rs1775151 chr1:205745684 C/T cg11965913 chr1:205819406 PM20D1 0.46 6.37 0.33 6.41e-10 Parkinson's disease; CRC cis rs6456156 0.846 rs7774396 chr6:167519786 G/A cg07513332 chr6:167530253 CCR6 0.38 6.37 0.33 6.39e-10 Primary biliary cholangitis; CRC cis rs317689 0.690 rs317656 chr12:69681101 T/A cg14784868 chr12:69753453 YEATS4 0.45 5.83 0.31 1.29e-8 Response to diuretic therapy; CRC cis rs2404602 0.583 rs2139190 chr15:76555539 G/C cg00316803 chr15:76480434 C15orf27 -0.38 -6.52 -0.34 2.69e-10 Blood metabolite levels; CRC cis rs10791323 0.576 rs4937840 chr11:133734322 C/G cg03690763 chr11:133734501 NA -0.4 -6.69 -0.35 9.84e-11 Childhood ear infection; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg07254608 chr8:41997973 NA 0.44 6.28 0.33 1.07e-9 Response to antipsychotic treatment; CRC cis rs1451375 1.000 rs6949897 chr7:50621920 C/T cg18232548 chr7:50535776 DDC 0.47 6.62 0.34 1.43e-10 Malaria; CRC cis rs3750082 0.817 rs2060731 chr7:32968346 G/A cg05721444 chr7:32995514 FKBP9 -0.5 -7.64 -0.39 2.36e-13 Glomerular filtration rate (creatinine); CRC cis rs11577318 0.853 rs4471263 chr1:26622700 C/T cg00852783 chr1:26633632 UBXN11 0.47 6.7 0.35 9.14e-11 Granulocyte percentage of myeloid white cells; CRC cis rs524023 0.915 rs531763 chr11:64352063 A/G cg14139581 chr11:64358342 SLC22A12 0.38 6.02 0.31 4.73e-9 Urate levels in obese individuals; CRC trans rs7726839 0.794 rs6883536 chr5:599274 G/A cg25482853 chr8:67687455 SGK3 0.71 8.91 0.44 3.62e-17 Obesity-related traits; CRC cis rs4731207 0.596 rs6466971 chr7:124596007 G/A cg23710748 chr7:124431027 NA -0.39 -6.14 -0.32 2.34e-9 Cutaneous malignant melanoma; CRC cis rs3806843 1.000 rs7732179 chr5:140199039 G/A cg19875535 chr5:140030758 IK 0.56 9.11 0.45 8.18e-18 Depressive symptoms (multi-trait analysis); CRC cis rs6495122 0.644 rs11630087 chr15:75261673 G/T cg14664628 chr15:75095509 CSK -0.53 -7.61 -0.39 2.87e-13 Caffeine consumption;Diastolic blood pressure;Coffee consumption; CRC cis rs780096 0.526 rs1260341 chr2:27663215 T/A cg27432699 chr2:27873401 GPN1 -0.51 -7.82 -0.4 7.11e-14 Total body bone mineral density; CRC cis rs7224685 0.501 rs781839 chr17:3961489 C/T cg11204139 chr17:3907470 NA 0.74 14.04 0.61 2.11e-35 Type 2 diabetes; CRC cis rs3772130 1.000 rs35988617 chr3:121432902 A/G cg20356878 chr3:121714668 ILDR1 0.51 7.76 0.39 1.08e-13 Cognitive performance; CRC cis rs9322817 0.691 rs2486138 chr6:105290223 G/A cg02098413 chr6:105308735 HACE1 0.44 8.72 0.43 1.42e-16 Thyroid stimulating hormone; CRC cis rs7737355 0.947 rs3776007 chr5:130875085 C/G cg06307176 chr5:131281290 NA -0.44 -6.46 -0.34 3.76e-10 Life satisfaction; CRC cis rs875971 0.522 rs4718285 chr7:65292005 A/G cg18876405 chr7:65276391 NA 0.65 11.92 0.55 1.86e-27 Aortic root size; CRC cis rs6540559 1.000 rs742215 chr1:209961023 A/T cg21951975 chr1:209979733 IRF6 0.45 6.64 0.34 1.27e-10 Cleft lip with or without cleft palate; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G ch.8.34907260F chr8:34787718 NA 0.51 7.96 0.4 2.82e-14 Liver disease severity in Alagille syndrome; CRC cis rs270601 0.710 rs371709 chr5:131583240 A/G cg04518342 chr5:131593106 PDLIM4 0.54 9.23 0.45 3.37e-18 Acylcarnitine levels; CRC cis rs453301 0.719 rs34004903 chr8:8892604 C/T cg06636001 chr8:8085503 FLJ10661 -0.47 -7.15 -0.37 5.61e-12 Joint mobility (Beighton score); CRC cis rs9311676 0.656 rs7620012 chr3:58373716 G/A cg06643156 chr3:58380774 PXK 0.41 6.33 0.33 7.82e-10 Systemic lupus erythematosus; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg12751404 chr1:11866034 MTHFR;CLCN6 0.41 6.56 0.34 2.04e-10 Liver disease severity in Alagille syndrome; CRC cis rs873946 0.564 rs12263364 chr10:134555548 G/T cg06453172 chr10:134556979 INPP5A -0.62 -7.98 -0.4 2.43e-14 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CRC cis rs67311347 1.000 rs2305521 chr3:40429183 A/G cg09455208 chr3:40491958 NA 0.43 8.86 0.44 5.25e-17 Renal cell carcinoma; CRC cis rs9733 0.526 rs11204698 chr1:150659545 G/A cg18016565 chr1:150552671 MCL1 0.47 6.82 0.35 4.33e-11 Tonsillectomy; CRC cis rs2952156 0.920 rs732083 chr17:37834367 G/A cg07936489 chr17:37558343 FBXL20 -0.45 -6.55 -0.34 2.25e-10 Asthma; CRC cis rs754466 0.874 rs61855849 chr10:79659934 G/A cg17075019 chr10:79541650 NA -0.74 -10.37 -0.5 5.59e-22 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs7605827 0.897 rs13017859 chr2:15537641 T/C cg19274914 chr2:15703543 NA 0.4 5.94 0.31 7.2e-9 Educational attainment (years of education); CRC cis rs12701220 0.857 rs1057558 chr7:1062366 A/G cg00990874 chr7:1149470 C7orf50 -0.48 -5.9 -0.31 8.93e-9 Bronchopulmonary dysplasia; CRC cis rs2836974 0.897 rs68090597 chr21:40535633 A/G cg17971929 chr21:40555470 PSMG1 0.84 13.1 0.59 7.54e-32 Cognitive function; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg06419771 chr15:42264912 EHD4 0.49 6.96 0.36 1.84e-11 Response to antipsychotic treatment; CRC cis rs28386778 0.897 rs2584635 chr17:61865934 A/G cg06873352 chr17:61820015 STRADA 0.8 15.32 0.65 2.36e-40 Prudent dietary pattern; CRC cis rs473651 0.904 rs551859 chr2:239371836 T/C cg18131467 chr2:239335373 ASB1 0.91 18.07 0.71 3.4e-51 Multiple system atrophy; CRC trans rs9858542 0.953 rs9827021 chr3:49514764 C/A cg21659725 chr3:3221576 CRBN -0.68 -9.33 -0.46 1.64e-18 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs6662572 0.737 rs72692613 chr1:46399557 A/C cg03123370 chr1:45965343 CCDC163P;MMACHC 0.45 5.62 0.3 4.06e-8 Blood protein levels; CRC trans rs208515 0.525 rs10755508 chr6:66675790 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.9 11.36 0.53 1.95e-25 Exhaled nitric oxide levels; CRC cis rs11190604 1.000 rs10786596 chr10:102282126 C/A cg07080220 chr10:102295463 HIF1AN 0.49 6.32 0.33 8.65e-10 Palmitoleic acid (16:1n-7) levels; CRC cis rs523516 0.645 rs16525 chr17:37321605 C/T cg20555674 chr17:37321631 ARL5C 0.4 8.38 0.42 1.59e-15 IgG glycosylation; CRC cis rs854765 0.583 rs2350977 chr17:17802779 A/G cg04398451 chr17:18023971 MYO15A -0.5 -8.55 -0.43 4.7e-16 Total body bone mineral density; CRC cis rs2404602 0.716 rs67888330 chr15:76752483 A/G cg22467129 chr15:76604101 ETFA -0.46 -7.8 -0.4 8.25e-14 Blood metabolite levels; CRC cis rs34172651 0.917 rs172066 chr16:24756449 C/T cg06028605 chr16:24865363 SLC5A11 0.39 7.45 0.38 8.45e-13 Intelligence (multi-trait analysis); CRC cis rs10416265 0.527 rs7246814 chr19:33538414 G/T cg27124370 chr19:33622961 WDR88 0.49 7.45 0.38 8.26e-13 Bone properties (heel); CRC cis rs910316 1.000 rs4903289 chr14:75623988 C/T cg11812906 chr14:75593930 NEK9 -0.63 -9.92 -0.48 1.86e-20 Height; CRC trans rs2303319 0.504 rs58622044 chr2:162596287 A/G cg22922770 chr7:98923339 ARPC1A -0.69 -6.19 -0.32 1.77e-9 Cognitive function; CRC cis rs7605827 0.930 rs11684001 chr2:15513120 C/T cg19274914 chr2:15703543 NA 0.38 5.8 0.3 1.59e-8 Educational attainment (years of education); CRC cis rs10504229 0.728 rs17215621 chr8:58152706 C/A cg02290350 chr8:58132656 NA -0.51 -6.57 -0.34 1.98e-10 Developmental language disorder (linguistic errors); CRC cis rs9467711 0.606 rs9379873 chr6:26402717 T/C cg08501292 chr6:25962987 TRIM38 0.79 6.2 0.32 1.68e-9 Autism spectrum disorder or schizophrenia; CRC trans rs9951602 0.512 rs8084836 chr18:76647841 A/G cg02800362 chr5:177631904 HNRNPAB 0.72 10.36 0.5 6.11e-22 Obesity-related traits; CRC cis rs28829049 0.597 rs71645438 chr1:19502349 G/A cg13387374 chr1:19411106 UBR4 0.42 6.14 0.32 2.39e-9 QRS duration in Tripanosoma cruzi seropositivity; CRC cis rs868943 0.512 rs72953957 chr6:116546543 A/G cg26893134 chr6:116381904 FRK 0.24 5.7 0.3 2.61e-8 Total cholesterol levels; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg17827632 chr1:161087992 PFDN2;NIT1 0.43 5.99 0.31 5.49e-9 Response to antipsychotic treatment; CRC trans rs9858542 1.000 rs9882740 chr3:49702484 T/C cg21582582 chr3:182698605 DCUN1D1 -0.56 -6.85 -0.35 3.7e-11 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC trans rs1814175 0.588 rs10839463 chr11:49971643 A/G cg03929089 chr4:120376271 NA -0.91 -16.21 -0.67 7.71e-44 Height; CRC cis rs6502050 0.761 rs13949 chr17:80059596 T/C cg13198984 chr17:80129470 CCDC57 -0.41 -6.76 -0.35 6.3e-11 Life satisfaction; CRC cis rs1862618 0.853 rs1423620 chr5:56100996 G/T cg18230493 chr5:56204884 C5orf35 -0.72 -9.29 -0.46 2.14e-18 Initial pursuit acceleration; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg05200610 chr12:72233572 TBC1D15 0.38 6.23 0.32 1.46e-9 Liver disease severity in Alagille syndrome; CRC trans rs2303319 0.504 rs62189052 chr2:162623869 C/G cg10272801 chr16:14013773 ERCC4 -0.68 -6.07 -0.32 3.49e-9 Cognitive function; CRC trans rs7829975 0.514 rs2979151 chr8:8258019 A/G cg16141378 chr3:129829833 LOC729375 0.49 7.32 0.37 1.86e-12 Mood instability; CRC cis rs6540559 0.673 rs17317411 chr1:209961314 C/T cg22029157 chr1:209979665 IRF6 -0.64 -7.25 -0.37 3.06e-12 Cleft lip with or without cleft palate; CRC cis rs6938 0.534 rs8025447 chr15:75192222 T/G cg14664628 chr15:75095509 CSK -0.68 -10.91 -0.52 7.11e-24 Breast cancer; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg17921034 chr13:42846375 AKAP11 0.47 6.77 0.35 5.81e-11 Response to antipsychotic treatment; CRC cis rs10876993 0.928 rs813854 chr12:58071347 A/G cg18357645 chr12:58087776 OS9 0.6 8.49 0.42 7.08e-16 Celiac disease or Rheumatoid arthritis; CRC cis rs2032447 0.798 rs807214 chr6:26061769 G/C cg18357526 chr6:26021779 HIST1H4A 0.73 11.23 0.53 5.48e-25 Intelligence (multi-trait analysis); CRC cis rs7937682 0.924 rs7924683 chr11:111555796 C/A cg19812747 chr11:111475976 SIK2 -0.55 -9.4 -0.46 9.4e-19 Primary sclerosing cholangitis; CRC cis rs41271951 0.512 rs77306500 chr1:151080096 G/C cg11822372 chr1:151115635 SEMA6C -0.7 -5.62 -0.3 4.02e-8 Blood protein levels; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg02111504 chr5:93954110 C5orf36;ANKRD32 0.48 6.05 0.32 3.87e-9 Thyroid stimulating hormone; CRC cis rs9928842 0.770 rs4888364 chr16:75279510 A/G cg09066997 chr16:75300724 BCAR1 0.64 6.16 0.32 2.07e-9 Alcoholic chronic pancreatitis; CRC cis rs9611565 0.659 rs17367849 chr22:41923644 G/A cg06634786 chr22:41940651 POLR3H -0.71 -8.32 -0.42 2.41e-15 Vitiligo; CRC cis rs7264396 0.561 rs6060741 chr20:34571484 C/T cg04508476 chr20:34239394 CPNE1;RBM12 0.61 8.32 0.42 2.31e-15 Total cholesterol levels; CRC cis rs7618501 0.521 rs11130222 chr3:49901060 A/T cg05623727 chr3:50126028 RBM5 0.63 10.67 0.51 4.91e-23 Intelligence (multi-trait analysis); CRC trans rs9784649 1.000 rs56156666 chr5:24999440 A/T cg11038491 chr20:34638489 LOC647979 -0.59 -7.06 -0.36 9.96e-12 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs919433 0.890 rs979020 chr2:198169749 T/C cg20885578 chr2:198174922 NA -0.41 -7.16 -0.37 5.29e-12 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC cis rs12893668 0.645 rs35229468 chr14:104052057 C/T cg08213375 chr14:104286397 PPP1R13B 0.36 5.76 0.3 1.94e-8 Reticulocyte count; CRC trans rs6076960 0.684 rs6054058 chr20:6262187 T/C cg21095983 chr6:86352623 SYNCRIP 0.58 8.45 0.42 9.33e-16 Smooth-surface caries; CRC cis rs73198271 0.813 rs17697237 chr8:8615874 A/C cg01851573 chr8:8652454 MFHAS1 -0.44 -6.64 -0.34 1.3100000000000001e-10 Bone ultrasound measurement (broadband ultrasound attenuation); CRC cis rs12188164 1.000 rs34453673 chr5:434722 G/C cg26850624 chr5:429559 AHRR -0.82 -13.92 -0.61 5.7e-35 Cystic fibrosis severity; CRC cis rs611744 0.647 rs615126 chr8:109247619 C/T cg18478394 chr8:109455254 TTC35 0.39 6.03 0.32 4.51e-9 Dupuytren's disease; CRC trans rs3780486 0.846 rs10971420 chr9:33125000 T/C cg20290983 chr6:43655470 MRPS18A 1.16 26.9 0.83 4.44e-85 IgG glycosylation; CRC cis rs8060686 0.641 rs12598256 chr16:68084021 G/A cg26727032 chr16:67993705 SLC12A4 -0.56 -6.47 -0.34 3.57e-10 HDL cholesterol;Metabolic syndrome; CRC cis rs3796352 0.667 rs11720228 chr3:52877270 G/A cg27565382 chr3:53032988 SFMBT1 0.76 6.12 0.32 2.6e-9 Immune reponse to smallpox (secreted IL-2); CRC cis rs881375 1.000 rs881375 chr9:123652898 T/C cg09586646 chr9:123605570 PSMD5;LOC253039 0.53 7.17 0.37 5.09e-12 Rheumatoid arthritis; CRC cis rs10071761 0.513 rs12517921 chr5:40375907 C/T cg09067459 chr5:40385259 NA 0.49 6.95 0.36 2e-11 Selective IgA deficiency; CRC cis rs801193 0.636 rs2659895 chr7:66196471 C/A cg18912574 chr7:65842487 NCRNA00174 0.35 5.91 0.31 8.52e-9 Aortic root size; CRC cis rs7727544 0.507 rs9791170 chr5:131569627 A/G cg24060327 chr5:131705240 SLC22A5 -0.4 -6.2 -0.32 1.71e-9 Blood metabolite levels; CRC cis rs4665809 0.590 rs7579504 chr2:26439995 T/C cg25036284 chr2:26402008 FAM59B -0.61 -7.76 -0.39 1.09e-13 Gut microbiome composition (summer); CRC trans rs2243480 1.000 rs1701758 chr7:65470201 T/A cg10756647 chr7:56101905 PSPH 0.73 7.98 0.4 2.44e-14 Diabetic kidney disease; CRC cis rs2573652 1.000 rs2581346 chr15:100514178 T/G cg00587665 chr15:100533223 ADAMTS17 -0.35 -5.92 -0.31 8.31e-9 Height; CRC cis rs990171 0.506 rs6543107 chr2:102750730 A/T cg22835712 chr2:102737379 NA 0.41 5.62 0.3 3.98e-8 Lymphocyte counts; CRC cis rs7493 0.853 rs2299266 chr7:95049073 A/G cg20119798 chr7:94954144 PON1 -0.51 -6.46 -0.34 3.83e-10 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs7493 0.755 rs34774523 chr7:94962142 G/A cg04155289 chr7:94953770 PON1 -0.56 -7.15 -0.37 5.66e-12 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs7617773 0.817 rs11130163 chr3:48312658 T/C cg11946769 chr3:48343235 NME6 0.55 8.01 0.4 2.03e-14 Coronary artery disease; CRC cis rs7662987 0.517 rs2602877 chr4:100039847 T/A cg13256891 chr4:100009986 ADH5 0.62 8.37 0.42 1.64e-15 Smoking initiation; CRC trans rs3008706 0.539 rs1328287 chr9:15918773 A/G cg15918921 chr2:74212782 NA -0.48 -5.98 -0.31 5.97e-9 Bilirubin levels; CRC cis rs4713118 0.621 rs10484403 chr6:28033523 A/G cg02631126 chr6:28058918 ZSCAN12L1 0.28 5.87 0.31 1.04e-8 Parkinson's disease; CRC cis rs7591163 1.000 rs4300818 chr2:228713255 G/T cg22079747 chr2:228736145 WDR69 -0.44 -5.88 -0.31 1.01e-8 Blood pressure; CRC cis rs9910055 0.762 rs1135215 chr17:42253519 T/C cg16434002 chr17:42200994 HDAC5 -0.47 -6.33 -0.33 8.12e-10 Total body bone mineral density; CRC cis rs9287719 0.934 rs12692416 chr2:10745627 A/G cg00105475 chr2:10696890 NA 0.45 7.21 0.37 3.91e-12 Prostate cancer; CRC cis rs3733585 0.673 rs6849729 chr4:9958732 T/C cg00071950 chr4:10020882 SLC2A9 -0.54 -9.65 -0.47 1.42e-19 Cleft plate (environmental tobacco smoke interaction); CRC cis rs651907 0.557 rs1031710 chr3:101463895 C/T cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.59 7.94 0.4 3.21e-14 Colorectal cancer; CRC cis rs7312933 0.558 rs7305397 chr12:42850058 T/C cg11827402 chr12:42719852 PPHLN1;ZCRB1 0.65 8.93 0.44 3.09e-17 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CRC cis rs877282 0.945 rs17293517 chr10:778770 C/T cg06581033 chr10:766294 NA -0.51 -5.69 -0.3 2.75e-8 Uric acid levels; CRC cis rs10540 1.000 rs61876332 chr11:487101 C/T cg03576123 chr11:487126 PTDSS2 -1.02 -10.25 -0.49 1.4e-21 Body mass index; CRC cis rs10971721 0.822 rs12380143 chr9:33847586 C/T cg13495928 chr9:33750294 PRSS3 0.55 5.9 0.31 9.17e-9 Body mass index; CRC cis rs2404602 0.669 rs9788684 chr15:77194838 A/T cg03037974 chr15:76606532 NA 0.67 11.08 0.52 1.83e-24 Blood metabolite levels; CRC cis rs9326248 0.520 rs6589602 chr11:117037065 T/C cg15534755 chr11:117069859 TAGLN 0.3 5.83 0.31 1.33e-8 Blood protein levels; CRC cis rs9891119 0.576 rs13342031 chr17:40536871 C/G cg06270615 chr17:40516068 STAT3 -0.35 -7.24 -0.37 3.13e-12 Multiple sclerosis;Crohn's disease; CRC cis rs933688 1.000 rs12651840 chr5:90729592 T/C cg26981201 chr5:90679533 LOC100129716;ARRDC3 1.06 17.02 0.68 4.77e-47 Smoking behavior; CRC cis rs7552404 0.727 rs7547508 chr1:76327958 A/G cg03433033 chr1:76189801 ACADM -0.64 -8.52 -0.43 5.91e-16 Blood metabolite levels;Acylcarnitine levels; CRC cis rs1707322 0.964 rs785499 chr1:46592420 G/A cg06784218 chr1:46089804 CCDC17 -0.61 -10.54 -0.5 1.37e-22 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs7528419 0.927 rs660240 chr1:109817838 T/C cg00908766 chr1:109817496 CELSR2 0.43 7.6 0.39 3.05e-13 Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease);Myocardial infarction;Lipoprotein-associated phospholipase A2 activity and mass;Lipoprotein-associated phospholipase A2 activity change in response to darapladib treatment in cardiovascular disease;Cholesterol, total;Coronary artery disease; CRC cis rs1018836 0.923 rs11784529 chr8:91640956 C/A cg16814680 chr8:91681699 NA -0.69 -10.56 -0.5 1.23e-22 Ejection fraction in Tripanosoma cruzi seropositivity; CRC cis rs11997175 0.624 rs4733179 chr8:33692223 T/G ch.8.33884649F chr8:33765107 NA 0.46 6.69 0.35 9.33e-11 Body mass index; CRC cis rs6502050 0.835 rs67682841 chr17:80117745 T/C cg09264619 chr17:80180166 NA -0.35 -5.93 -0.31 7.76e-9 Life satisfaction; CRC cis rs7945705 0.870 rs1109305 chr11:8955272 C/T cg00186954 chr11:8933980 ST5;C11orf17 0.45 6.88 0.35 3.04e-11 Hemoglobin concentration; CRC cis rs73206853 0.841 rs118053970 chr12:110932820 C/G cg12870014 chr12:110450643 ANKRD13A 0.76 6.63 0.34 1.34e-10 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC cis rs9611565 0.546 rs34077262 chr22:42061639 A/G cg03806693 chr22:41940476 POLR3H 0.79 10.62 0.51 7.77e-23 Vitiligo; CRC cis rs6968419 0.755 rs3173919 chr7:115898177 G/C cg02561103 chr7:115862891 TES -0.44 -6.61 -0.34 1.51e-10 Intraocular pressure; CRC cis rs9733 0.596 rs6587518 chr1:150661787 T/C cg17724175 chr1:150552817 MCL1 0.59 9.4 0.46 9.36e-19 Tonsillectomy; CRC cis rs13217239 0.621 rs12527231 chr6:27001288 G/A cg05192639 chr6:26864778 GUSBL1 0.31 6.05 0.32 4.01e-9 Schizophrenia; CRC cis rs1552244 1.000 rs113134644 chr3:10086286 G/A cg13047869 chr3:10149882 C3orf24 0.54 7.48 0.38 6.65e-13 Alzheimer's disease; CRC cis rs1862618 0.671 rs832531 chr5:56228401 A/G cg03609598 chr5:56110824 MAP3K1 -0.6 -8.12 -0.41 9.67e-15 Initial pursuit acceleration; CRC cis rs561341 1.000 rs546519 chr17:30297682 T/G cg00745463 chr17:30367425 LRRC37B -0.75 -9.09 -0.45 9.8e-18 Hip circumference adjusted for BMI; CRC cis rs11971779 0.648 rs7799165 chr7:139084957 G/T cg23387468 chr7:139079360 LUC7L2 0.41 7.04 0.36 1.14e-11 Diisocyanate-induced asthma; CRC cis rs12824058 0.831 rs11060825 chr12:130807905 A/G cg26677194 chr12:130822605 PIWIL1 0.44 7.06 0.36 1.01e-11 Menopause (age at onset); CRC trans rs7939886 0.920 rs11534518 chr11:55808146 C/T cg03929089 chr4:120376271 NA 0.66 5.98 0.31 5.9e-9 Myopia (pathological); CRC cis rs35110281 0.667 rs2155722 chr21:45096206 A/G cg21573476 chr21:45109991 RRP1B 0.38 5.73 0.3 2.27e-8 Mean corpuscular volume; CRC trans rs2303319 0.504 rs62189046 chr2:162612371 C/G cg09481857 chr22:21368659 P2RX6;MGC16703 -0.65 -6.31 -0.33 9.13e-10 Cognitive function; CRC cis rs12760731 0.920 rs6695982 chr1:178480733 A/G cg00404053 chr1:178313656 RASAL2 0.57 6.85 0.35 3.65e-11 Obesity-related traits; CRC cis rs4713118 0.516 rs6931858 chr6:28078411 A/T cg12273811 chr6:28175739 NA 0.68 8.48 0.42 7.53e-16 Parkinson's disease; CRC cis rs1018836 0.923 rs2023626 chr8:91619264 G/T cg16814680 chr8:91681699 NA 0.74 11.94 0.55 1.48e-27 Ejection fraction in Tripanosoma cruzi seropositivity; CRC cis rs1878931 0.567 rs7196196 chr16:3411855 C/A cg26668626 chr16:3451006 ZNF174;ZNF434 0.88 14.22 0.62 4.28e-36 Body mass index (adult); CRC cis rs10504229 0.679 rs72649120 chr8:58040308 C/T cg22535103 chr8:58192502 C8orf71 -0.45 -5.77 -0.3 1.78e-8 Developmental language disorder (linguistic errors); CRC cis rs17443541 0.507 rs4675719 chr2:200472364 C/T cg03741458 chr2:200468445 NA -0.36 -5.64 -0.3 3.61e-8 Intelligence (multi-trait analysis); CRC cis rs875971 0.862 rs949930 chr7:65766822 C/G cg12463550 chr7:65579703 CRCP -0.52 -7.38 -0.38 1.33e-12 Aortic root size; CRC cis rs1008375 0.966 rs6825133 chr4:17577776 C/T cg02297831 chr4:17616191 MED28 0.44 5.73 0.3 2.27e-8 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs9486715 0.867 rs3849199 chr6:97049191 T/C cg06623918 chr6:96969491 KIAA0776 -1.02 -20.58 -0.75 4.48e-61 Headache; CRC cis rs16858210 0.913 rs1879255 chr3:183609445 C/A cg25686905 chr3:183603175 PARL -0.41 -5.74 -0.3 2.18e-8 Menopause (age at onset); CRC trans rs3780486 0.846 rs6476402 chr9:33148552 G/A cg20290983 chr6:43655470 MRPS18A 1.14 24.94 0.81 7.96e-78 IgG glycosylation; CRC cis rs801193 1.000 rs2707850 chr7:66203870 G/T cg18876405 chr7:65276391 NA 0.6 10.61 0.51 7.98e-23 Aortic root size; CRC trans rs3960554 0.569 rs1894761 chr7:75876754 C/T cg19862616 chr7:65841803 NCRNA00174 -0.5 -7.08 -0.36 8.73e-12 Eotaxin levels; CRC cis rs362272 0.524 rs13150241 chr4:3367281 A/G cg02993699 chr4:3415135 RGS12 -0.4 -6.35 -0.33 6.98e-10 Serum sulfate level; CRC cis rs12541335 0.639 rs11779277 chr8:22200683 C/T cg02788857 chr8:22132959 PIWIL2 0.5 8.53 0.43 5.57e-16 Hypertriglyceridemia; CRC cis rs13064447 0.753 rs9868500 chr3:12747690 A/G cg07775309 chr3:12595852 NA -0.36 -5.83 -0.31 1.34e-8 Major depression and alcohol dependence; CRC cis rs6504950 0.800 rs9891704 chr17:53010755 A/G cg26251398 chr17:52985966 TOM1L1 0.37 5.62 0.3 4.04e-8 Breast cancer; CRC cis rs35110281 0.837 rs12627667 chr21:45071396 A/C cg04455712 chr21:45112962 RRP1B 0.41 7.82 0.4 7.38e-14 Mean corpuscular volume; CRC cis rs875971 0.862 rs709609 chr7:65560561 A/G cg12463550 chr7:65579703 CRCP -0.53 -7.55 -0.38 4.32e-13 Aortic root size; CRC cis rs1577917 0.572 rs911927 chr6:86327860 C/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.57 -7.94 -0.4 3.24e-14 Response to antipsychotic treatment; CRC trans rs3733585 0.631 rs7699671 chr4:10125874 C/T cg26043149 chr18:55253948 FECH -0.56 -8.12 -0.41 9.47e-15 Cleft plate (environmental tobacco smoke interaction); CRC cis rs501120 1.000 rs620828 chr10:44760958 A/G cg09554077 chr10:44749378 NA 0.78 11.96 0.55 1.33e-27 Coronary artery disease;Coronary heart disease; CRC cis rs2062225 1.000 rs2128813 chr2:111758774 T/C cg11729679 chr2:111877065 BCL2L11 -0.56 -5.64 -0.3 3.67e-8 Monocyte count; CRC cis rs7259376 0.905 rs62118584 chr19:22541142 G/A cg02657401 chr19:22469223 NA -0.34 -7.52 -0.38 5.1e-13 Menopause (age at onset); CRC cis rs758324 0.947 rs1846650 chr5:131158767 C/T cg25547332 chr5:131281432 NA 0.39 5.73 0.3 2.25e-8 Alzheimer's disease in APOE e4- carriers; CRC cis rs7572644 0.640 rs4666014 chr2:28019175 A/G cg27432699 chr2:27873401 GPN1 -0.49 -6.47 -0.34 3.53e-10 Response to carboplatin and paclitaxel in ovarian cancer (Caspase 3/7 EC50); CRC cis rs561341 1.000 rs72823785 chr17:30273784 C/T cg19193384 chr17:30244184 NA -0.65 -7.48 -0.38 6.75e-13 Hip circumference adjusted for BMI; CRC cis rs7727544 0.735 rs274568 chr5:131713578 C/T cg12564285 chr5:131593104 PDLIM4 -0.31 -5.71 -0.3 2.51e-8 Blood metabolite levels; CRC cis rs7618915 0.547 rs62253733 chr3:52653414 A/G cg15147215 chr3:52552868 STAB1 -0.62 -10.25 -0.49 1.37e-21 Bipolar disorder; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg18635645 chr1:85667791 SYDE2 0.49 6.7 0.35 9.28e-11 Thyroid stimulating hormone; CRC cis rs826838 0.967 rs980572 chr12:39127673 A/C cg13010199 chr12:38710504 ALG10B 0.42 5.91 0.31 8.68e-9 Heart rate; CRC cis rs651907 0.535 rs34263427 chr3:101507805 A/G cg12386194 chr3:101231763 SENP7 0.51 7.36 0.38 1.49e-12 Colorectal cancer; CRC cis rs9916302 0.904 rs6503519 chr17:37706578 A/G cg03013999 chr17:37608204 MED1 0.47 7.27 0.37 2.66e-12 Glomerular filtration rate (creatinine); CRC trans rs944990 0.595 rs10123378 chr9:96375217 C/T cg01858300 chr15:41233997 NA 0.44 6.76 0.35 6.48e-11 Body mass index; CRC cis rs1707322 1.000 rs11211236 chr1:46443767 C/A cg06784218 chr1:46089804 CCDC17 0.51 8.96 0.44 2.39e-17 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs7259376 0.840 rs1808668 chr19:22518657 A/G cg02657401 chr19:22469223 NA -0.37 -8.18 -0.41 6.14e-15 Menopause (age at onset); CRC cis rs4969178 0.965 rs11077364 chr17:76400337 C/A cg20026190 chr17:76395443 PGS1 0.38 5.68 0.3 2.95e-8 HDL cholesterol levels; CRC cis rs9611565 0.659 rs56319767 chr22:41933837 G/A cg06481639 chr22:41940642 POLR3H -0.54 -6.25 -0.33 1.29e-9 Vitiligo; CRC cis rs10046574 0.561 rs11505984 chr7:135208359 G/A cg27474649 chr7:135195673 CNOT4 0.61 5.95 0.31 7.03e-9 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs4975709 0.589 rs4975745 chr5:1861058 G/C cg20790798 chr5:1857306 NA -0.45 -6.87 -0.35 3.19e-11 Cardiovascular disease risk factors; CRC cis rs736408 0.507 rs6445531 chr3:52717282 T/C cg18099408 chr3:52552593 STAB1 -0.47 -8.0 -0.4 2.22e-14 Bipolar disorder; CRC cis rs9902453 0.933 rs4470197 chr17:28464474 T/C cg26525008 chr17:28256777 EFCAB5;SSH2 0.61 9.56 0.47 2.94e-19 Coffee consumption (cups per day); CRC cis rs2882667 0.858 rs11959803 chr5:138451315 G/A cg09476006 chr5:138032270 NA 0.44 6.78 0.35 5.71e-11 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs1997103 1.000 rs6593233 chr7:55406200 C/T cg17469321 chr7:55412551 NA -0.7 -10.96 -0.52 5.01e-24 QRS interval (sulfonylurea treatment interaction); CRC cis rs10504229 1.000 rs68112919 chr8:58188247 G/A cg02725872 chr8:58115012 NA -0.38 -6.44 -0.33 4.16e-10 Developmental language disorder (linguistic errors); CRC cis rs7408868 0.764 rs62113791 chr19:15277009 C/T cg14696996 chr19:15285081 NOTCH3 0.96 9.0 0.44 1.82e-17 Pulse pressure; CRC cis rs748404 0.631 rs2412781 chr15:43667900 C/T cg02155558 chr15:43621948 ADAL;LCMT2 -0.49 -7.01 -0.36 1.36e-11 Lung cancer; CRC cis rs7809950 1.000 rs2253146 chr7:107200319 A/G cg23024343 chr7:107201750 COG5 -0.61 -8.53 -0.43 5.56e-16 Coronary artery disease; CRC cis rs4665809 0.590 rs7586047 chr2:26447335 A/G cg27170947 chr2:26402098 FAM59B -0.59 -7.71 -0.39 1.53e-13 Gut microbiome composition (summer); CRC cis rs7727544 0.716 rs11955347 chr5:131567924 G/A cg18301423 chr5:131593218 PDLIM4 0.31 5.7 0.3 2.69e-8 Blood metabolite levels; CRC cis rs2882667 0.858 rs11242447 chr5:138426173 T/C cg09476006 chr5:138032270 NA 0.44 6.76 0.35 6.23e-11 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs6088590 1.000 rs55753039 chr20:33394940 C/T cg24642439 chr20:33292090 TP53INP2 0.6 10.57 0.5 1.16e-22 Coronary artery disease; CRC cis rs7917772 0.636 rs4418737 chr10:104525123 A/G cg04362960 chr10:104952993 NT5C2 0.46 6.18 0.32 1.85e-9 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC cis rs7647973 1.000 rs74471041 chr3:49542543 T/G cg20833759 chr3:49053208 WDR6;DALRD3 -0.55 -8.02 -0.4 1.91e-14 Menarche (age at onset); CRC cis rs1129187 0.755 rs13215983 chr6:42924193 C/T cg27588902 chr6:42928151 GNMT -0.4 -7.28 -0.37 2.43e-12 Alzheimer's disease in APOE e4+ carriers; CRC cis rs7932354 0.528 rs7103581 chr11:47072805 G/T cg19486271 chr11:47235900 DDB2 -0.44 -6.59 -0.34 1.74e-10 Bone mineral density (hip);Bone mineral density; CRC cis rs4665809 0.590 rs4665315 chr2:26416036 T/G cg08067268 chr2:26466485 HADHB;HADHA -0.66 -8.45 -0.42 9.58e-16 Gut microbiome composition (summer); CRC cis rs7215564 0.908 rs8070102 chr17:78683982 C/T cg09596252 chr17:78655493 RPTOR 0.56 6.15 0.32 2.26e-9 Myopia (pathological); CRC cis rs72634258 0.945 rs34124834 chr1:8028930 T/G cg26816564 chr1:7831052 VAMP3 0.62 6.6 0.34 1.6e-10 Inflammatory bowel disease; CRC cis rs10540 1.000 rs61876333 chr11:487136 G/A cg03576123 chr11:487126 PTDSS2 -1.11 -10.69 -0.51 4.31e-23 Body mass index; CRC trans rs916888 0.610 rs199452 chr17:44801340 C/T cg01341218 chr17:43662625 NA 0.58 7.48 0.38 6.61e-13 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs10504229 1.000 rs67344620 chr8:58187537 C/A cg05313129 chr8:58192883 C8orf71 -0.47 -6.99 -0.36 1.49e-11 Developmental language disorder (linguistic errors); CRC cis rs832540 0.669 rs832539 chr5:56199386 A/C cg24531977 chr5:56204891 C5orf35 -0.61 -9.21 -0.45 3.88e-18 Coronary artery disease; CRC cis rs9486719 0.843 rs2499797 chr6:96848669 C/T cg06623918 chr6:96969491 KIAA0776 0.78 8.57 0.43 4.13e-16 Migraine;Coronary artery disease; CRC cis rs9467711 0.606 rs9379852 chr6:26357278 A/G cg16898833 chr6:26189333 HIST1H4D 0.75 6.55 0.34 2.26e-10 Autism spectrum disorder or schizophrenia; CRC cis rs9292777 0.865 rs6871591 chr5:40406130 T/A cg09067459 chr5:40385259 NA 0.52 9.11 0.45 8.41e-18 Crohn's disease;Multiple sclerosis; CRC cis rs7647973 1.000 rs1982861 chr3:49577665 A/G cg07636037 chr3:49044803 WDR6 0.68 8.2 0.41 5.55e-15 Menarche (age at onset); CRC cis rs11209185 0.545 rs1926284 chr1:68446291 T/C cg22082780 chr1:68452167 NA 0.39 5.98 0.31 5.89e-9 Itch intensity from mosquito bite adjusted by bite size; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg16931877 chr3:32726605 CNOT10 -0.39 -6.38 -0.33 6.07e-10 Myopia (pathological); CRC cis rs9902453 1.000 rs4075623 chr17:28386526 A/G cg26525008 chr17:28256777 EFCAB5;SSH2 -0.59 -8.86 -0.44 4.95e-17 Coffee consumption (cups per day); CRC cis rs10191773 0.589 rs72831638 chr2:112949212 C/G cg24977338 chr2:113188963 RGPD8;RGPD5 -0.66 -5.75 -0.3 2.07e-8 Yeast infection; CRC cis rs731174 0.802 rs628492 chr1:38178277 G/A cg06917450 chr1:38156652 C1orf109 -0.52 -7.05 -0.36 1.06e-11 Prostate cancer (SNP x SNP interaction); CRC cis rs6502050 0.835 rs4499294 chr17:80148346 C/T cg13198984 chr17:80129470 CCDC57 0.43 7.56 0.38 3.92e-13 Life satisfaction; CRC cis rs79349575 0.681 rs56080003 chr17:47019049 A/T cg00947319 chr17:47005597 UBE2Z -0.34 -5.89 -0.31 9.32e-9 Type 2 diabetes; CRC cis rs992157 0.798 rs10206064 chr2:219157959 T/C cg04880052 chr2:219191631 PNKD 0.42 6.76 0.35 6.16e-11 Colorectal cancer; CRC cis rs2974760 0.606 rs2858918 chr16:201183 T/C cg08400316 chr16:204221 HBZ 0.67 10.3 0.49 9.62e-22 Mean corpuscular volume;Mean corpuscular hemoglobin; CRC cis rs10540 1.000 rs61877760 chr11:506596 C/T cg03352830 chr11:487213 PTDSS2 0.66 7.53 0.38 4.88e-13 Body mass index; CRC cis rs754466 0.651 rs11002322 chr10:79649653 G/T cg17075019 chr10:79541650 NA -0.87 -14.63 -0.63 1.06e-37 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs7020830 0.571 rs3780335 chr9:37376587 A/G cg14294708 chr9:37120828 ZCCHC7 -0.81 -11.09 -0.52 1.77e-24 Schizophrenia; CRC cis rs60843830 0.964 rs17713568 chr2:242132 G/A cg25945732 chr2:264204 ACP1;SH3YL1 0.73 11.98 0.55 1.05e-27 Spherical equivalent (joint analysis main effects and education interaction); CRC cis rs4332037 0.707 rs73046323 chr7:1882795 G/A cg23422044 chr7:1970798 MAD1L1 -0.48 -6.17 -0.32 1.99e-9 Bipolar disorder; CRC cis rs6831352 1.000 rs6837685 chr4:100049145 G/A cg13256891 chr4:100009986 ADH5 0.61 8.71 0.43 1.48e-16 Alcohol dependence; CRC cis rs35520189 0.591 rs67995749 chr2:113700892 G/A cg12858261 chr2:113808755 IL1F8 0.49 6.87 0.35 3.29e-11 Obstructive sleep apnea trait (apnea hypopnea index); CRC cis rs17818399 0.547 rs7607308 chr2:46759104 T/C cg26688816 chr2:46740690 ATP6V1E2 -0.49 -6.22 -0.32 1.53e-9 Height; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg03535439 chr6:42981950 MEA1;KLHDC3 0.41 6.51 0.34 2.74e-10 Liver disease severity in Alagille syndrome; CRC cis rs9527 0.590 rs3781281 chr10:104852648 A/G cg15744005 chr10:104629667 AS3MT 0.33 6.49 0.34 3.08e-10 Arsenic metabolism; CRC trans rs2531992 1.000 rs710893 chr16:4014964 A/G cg09155362 chr15:33487289 NA -0.53 -6.34 -0.33 7.51e-10 Waist circumference; CRC cis rs6582630 0.537 rs11520294 chr12:38402705 C/A cg13010199 chr12:38710504 ALG10B 0.45 5.72 0.3 2.42e-8 Drug-induced liver injury (flucloxacillin); CRC cis rs6804368 0.531 rs9819044 chr3:30770520 C/T cg06106510 chr3:30762233 NA 0.35 5.7 0.3 2.73e-8 Blood metabolite levels; CRC cis rs10256972 0.684 rs2363279 chr7:1096143 A/G cg16145915 chr7:1198662 ZFAND2A -0.3 -5.69 -0.3 2.79e-8 Longevity;Endometriosis; CRC cis rs9938149 0.618 rs35542380 chr16:88299593 G/C cg05435882 chr16:88311214 NA -0.47 -6.17 -0.32 1.96e-9 Corneal structure;Central corneal thickness; CRC cis rs7843479 0.965 rs3816786 chr8:21860425 A/T cg17168535 chr8:21777572 XPO7 0.51 8.06 0.41 1.47e-14 Mean corpuscular volume; CRC cis rs9611565 0.694 rs9607816 chr22:41950897 G/A cg17554472 chr22:41940697 POLR3H -0.56 -6.07 -0.32 3.45e-9 Vitiligo; CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg25118631 chr4:120206103 USP53 -0.53 -6.7 -0.35 8.84e-11 Diisocyanate-induced asthma; CRC trans rs3780486 0.846 rs10116966 chr9:33122370 T/A cg04842962 chr6:43655489 MRPS18A 1.14 25.01 0.81 4.37e-78 IgG glycosylation; CRC cis rs72634258 0.796 rs6703955 chr1:8165975 C/G cg00042356 chr1:8021962 PARK7 -0.53 -6.24 -0.33 1.36e-9 Inflammatory bowel disease; CRC cis rs9534288 0.797 rs7995256 chr13:46579414 A/T cg15192986 chr13:46630673 CPB2 -0.67 -9.85 -0.48 3.16e-20 Blood protein levels; CRC cis rs35110281 0.774 rs9978811 chr21:44998683 C/T cg04455712 chr21:45112962 RRP1B 0.41 7.88 0.4 4.8e-14 Mean corpuscular volume; CRC cis rs17270561 0.609 rs4145216 chr6:25743559 G/A cg17691542 chr6:26056736 HIST1H1C 0.72 9.24 0.45 3.07e-18 Iron status biomarkers; CRC cis rs904251 0.686 rs931649 chr6:37466079 T/C cg25019722 chr6:37503610 NA -0.38 -5.61 -0.3 4.19e-8 Cognitive performance; CRC cis rs35740288 0.539 rs4843100 chr15:86339210 G/C cg20737812 chr15:86336631 KLHL25 -0.48 -7.6 -0.39 3.16e-13 Eosinophil percentage of white cells;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes; CRC trans rs7647973 0.710 rs1532204 chr3:49609477 C/G cg21665057 chr3:196295764 WDR53;FBXO45 -0.67 -6.94 -0.36 2.13e-11 Menarche (age at onset); CRC cis rs9322193 0.884 rs2064521 chr6:149946472 A/C cg00933542 chr6:150070202 PCMT1 -0.3 -6.09 -0.32 3.1e-9 Lung cancer; CRC cis rs4253772 0.591 rs6519993 chr22:46656479 A/G cg24881330 chr22:46731750 TRMU 0.6 7.07 0.36 9.23e-12 LDL cholesterol;Cholesterol, total; CRC cis rs2204008 0.543 rs2387018 chr12:38065638 C/T cg13010199 chr12:38710504 ALG10B 0.45 5.77 0.3 1.86e-8 Bladder cancer; CRC cis rs62244186 0.566 rs6766221 chr3:44882784 C/T cg10263370 chr3:44754102 ZNF502 -0.36 -5.99 -0.31 5.36e-9 Depressive symptoms; CRC cis rs7613875 0.578 rs2526749 chr3:50076734 A/G cg24308560 chr3:49941425 MST1R 0.43 6.82 0.35 4.29e-11 Body mass index; CRC cis rs12594515 1.000 rs11070464 chr15:45984776 C/A cg19682013 chr15:45996608 NA 0.35 7.17 0.37 5.09e-12 Waist circumference;Weight; CRC cis rs4332037 0.539 rs62444881 chr7:2052318 C/T cg24505167 chr7:1915268 MAD1L1 -0.44 -5.98 -0.31 5.89e-9 Bipolar disorder; CRC cis rs9381040 0.655 rs2268188 chr6:41042590 T/G cg04346459 chr6:41068666 NFYA;LOC221442 -0.4 -5.81 -0.31 1.47e-8 Alzheimer's disease (late onset); CRC cis rs7914558 0.966 rs10748839 chr10:104953547 A/G cg15744005 chr10:104629667 AS3MT -0.33 -6.79 -0.35 5.24e-11 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs4332037 0.552 rs11773627 chr7:2002733 A/G cg25834613 chr7:1915315 MAD1L1 -0.39 -5.88 -0.31 1.03e-8 Bipolar disorder; CRC cis rs12900413 0.603 rs2118848 chr15:90302503 T/C cg24249390 chr15:90295951 MESP1 -0.62 -9.79 -0.47 5.03e-20 Coronary artery aneurysm in Kawasaki disease; CRC cis rs637571 0.615 rs10160792 chr11:65667149 C/G cg04055107 chr11:65626734 MUS81;CFL1 0.49 6.83 0.35 4.15e-11 Eosinophil percentage of white cells; CRC cis rs611744 0.647 rs2848620 chr8:109249551 G/T cg18478394 chr8:109455254 TTC35 0.37 5.78 0.3 1.75e-8 Dupuytren's disease; CRC cis rs7918232 0.800 rs7907981 chr10:27444329 T/C cg14442939 chr10:27389572 ANKRD26 0.9 11.58 0.54 3.04e-26 Breast cancer; CRC cis rs6684514 1.000 rs2296375 chr1:156309372 G/C cg16558208 chr1:156270281 VHLL 0.55 8.56 0.43 4.27e-16 Mean corpuscular hemoglobin concentration;Glycated hemoglobin levels; CRC cis rs9291683 0.546 rs13139055 chr4:10038924 G/T cg00071950 chr4:10020882 SLC2A9 0.63 11.2 0.53 6.78e-25 Bone mineral density; CRC trans rs7618501 1.000 rs34451146 chr3:49813013 C/T cg21665057 chr3:196295764 WDR53;FBXO45 0.86 15.78 0.66 3.78e-42 Intelligence (multi-trait analysis); CRC trans rs61931739 0.500 rs6488222 chr12:34526289 G/A cg26384229 chr12:38710491 ALG10B 0.67 8.81 0.44 7.35e-17 Morning vs. evening chronotype; CRC cis rs853679 0.550 rs1150692 chr6:28173957 A/G cg21251018 chr6:28226885 NKAPL 0.45 6.43 0.33 4.5e-10 Depression; CRC cis rs10789491 1.000 rs1890473 chr1:47149794 C/T cg15501359 chr1:47185051 KIAA0494 0.63 8.09 0.41 1.2e-14 Response to hepatitis C treatment; CRC cis rs4132509 0.744 rs7519673 chr1:243993123 A/G cg21452805 chr1:244014465 NA 0.61 6.34 0.33 7.61e-10 RR interval (heart rate); CRC cis rs25422 0.938 rs114309775 chr6:118838782 G/A cg18833306 chr6:118973337 C6orf204 0.45 5.95 0.31 6.94e-9 Renal cell carcinoma; CRC cis rs921968 0.541 rs642520 chr2:219423605 A/G cg02176678 chr2:219576539 TTLL4 -0.53 -8.51 -0.42 6.33e-16 Mean corpuscular hemoglobin concentration; CRC cis rs8044995 0.517 rs61593058 chr16:68384496 T/C cg26727032 chr16:67993705 SLC12A4 -0.46 -6.14 -0.32 2.34e-9 Schizophrenia; CRC cis rs6582630 0.555 rs11613249 chr12:38519339 T/C cg13010199 chr12:38710504 ALG10B 0.48 6.4 0.33 5.21e-10 Drug-induced liver injury (flucloxacillin); CRC cis rs10504229 0.639 rs2291764 chr8:58142943 A/C cg08219700 chr8:58056026 NA 0.56 6.48 0.34 3.28e-10 Developmental language disorder (linguistic errors); CRC cis rs9611565 0.592 rs9611613 chr22:41961831 T/C cg03806693 chr22:41940476 POLR3H -0.89 -11.17 -0.52 8.84e-25 Vitiligo; CRC cis rs2243480 1.000 rs778729 chr7:65824419 T/C cg18252515 chr7:66147081 NA -1.31 -15.31 -0.64 2.59e-40 Diabetic kidney disease; CRC trans rs208520 0.690 rs7764570 chr6:66827600 G/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.99 -13.71 -0.6 3.64e-34 Exhaled nitric oxide output; CRC cis rs9902453 1.000 rs9890886 chr17:28391076 A/G cg26525008 chr17:28256777 EFCAB5;SSH2 -0.59 -8.78 -0.44 8.99e-17 Coffee consumption (cups per day); CRC cis rs67340775 0.541 rs200968 chr6:27859568 T/C cg26587870 chr6:27730563 NA -0.56 -6.47 -0.34 3.49e-10 Lung cancer in ever smokers; CRC cis rs11212617 1.000 rs654005 chr11:108155397 G/A cg01991180 chr11:108092276 ATM;NPAT 0.43 6.26 0.33 1.19e-9 Response to metformin in type 2 diabetes (glycemic); CRC trans rs916888 0.821 rs199505 chr17:44859410 A/G cg01341218 chr17:43662625 NA -0.83 -9.39 -0.46 1.03e-18 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs10504229 0.679 rs11783963 chr8:58130496 T/A cg21724239 chr8:58056113 NA 0.49 6.81 0.35 4.75e-11 Developmental language disorder (linguistic errors); CRC trans rs6950442 0.556 rs647318 chr7:114346537 A/C cg08672999 chr19:52675203 ZNF836 -0.54 -6.92 -0.36 2.34e-11 Body mass index; CRC cis rs9326248 0.689 rs4516002 chr11:116999059 A/G cg11861562 chr11:117069780 TAGLN 0.37 6.04 0.32 4.15e-9 Blood protein levels; CRC cis rs6963495 0.674 rs75880756 chr7:105163821 G/C cg02135003 chr7:105160482 PUS7 -0.9 -12.2 -0.56 1.71e-28 Bipolar disorder (body mass index interaction); CRC cis rs10905065 0.827 rs10752111 chr10:5837286 T/C cg25171089 chr10:5708825 ASB13 0.4 5.73 0.3 2.27e-8 Menopause (age at onset); CRC cis rs9443645 0.901 rs3805747 chr6:79672522 A/G cg11833968 chr6:79620685 NA -0.36 -6.21 -0.32 1.58e-9 Intelligence (multi-trait analysis); CRC cis rs548181 0.545 rs4486648 chr11:125610589 T/A cg03464685 chr11:125439445 EI24 -1.01 -11.08 -0.52 1.91e-24 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs1519814 1.000 rs10087151 chr8:121172261 C/T cg22335954 chr8:121166405 COL14A1 -0.55 -6.88 -0.35 3.04e-11 Breast cancer; CRC cis rs875971 1.000 rs778685 chr7:65836176 G/T cg18876405 chr7:65276391 NA 0.52 9.04 0.45 1.37e-17 Aortic root size; CRC cis rs4862750 0.872 rs6852907 chr4:187897094 A/C cg27532560 chr4:187881888 NA -0.56 -10.23 -0.49 1.63e-21 Lobe attachment (rater-scored or self-reported); CRC cis rs4363385 0.747 rs7521181 chr1:152955223 G/A cg25856811 chr1:152973957 SPRR3 -0.26 -7.22 -0.37 3.65e-12 Inflammatory skin disease; CRC cis rs10911251 0.508 rs944970 chr1:183112566 T/C ch.1.3577855R chr1:183094577 LAMC1 0.83 14.65 0.63 9.3e-38 Colorectal cancer; CRC cis rs8180040 0.620 rs6767907 chr3:47162661 C/T cg27129171 chr3:47204927 SETD2 -0.7 -11.06 -0.52 2.23e-24 Colorectal cancer; CRC cis rs812925 0.537 rs778139 chr2:61684564 A/G cg10580144 chr2:61372316 C2orf74 -0.33 -7.02 -0.36 1.31e-11 Immature fraction of reticulocytes; CRC cis rs2692947 0.631 rs2312954 chr2:96772447 C/T cg23100626 chr2:96804247 ASTL -0.27 -7.22 -0.37 3.61e-12 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; CRC cis rs10779751 0.762 rs1074078 chr1:11326788 C/T cg08854313 chr1:11322531 MTOR -0.44 -5.73 -0.3 2.25e-8 Body mass index; CRC cis rs62064224 0.614 rs9916114 chr17:30766950 T/C cg09324608 chr17:30823087 MYO1D 0.35 5.93 0.31 7.51e-9 Schizophrenia; CRC cis rs780096 0.505 rs12475426 chr2:27599132 G/A cg12000995 chr2:27665139 KRTCAP3 -0.3 -6.24 -0.33 1.36e-9 Total body bone mineral density; CRC cis rs6461049 0.765 rs1476887 chr7:2151633 T/C cg21782813 chr7:2030301 MAD1L1 0.47 8.34 0.42 2.05e-15 Schizophrenia; CRC cis rs1065852 0.526 rs739296 chr22:42389948 A/G cg22189786 chr22:42395067 WBP2NL -0.42 -6.3 -0.33 9.39e-10 Response to serotonin reuptake inhibitors in major depressive disorder (plasma drug and metabolite levels); CRC cis rs910316 0.967 rs175432 chr14:75615246 C/G cg08847533 chr14:75593920 NEK9 -0.89 -16.19 -0.67 9.31e-44 Height; CRC cis rs4973397 0.810 rs12694890 chr2:232276553 A/T cg13347044 chr2:232276743 NA -0.52 -7.52 -0.38 5.19e-13 Anti-saccade response; CRC cis rs17826219 0.500 rs57005940 chr17:29066329 C/G cg13385521 chr17:29058706 SUZ12P 0.72 8.17 0.41 6.77e-15 Body mass index; CRC cis rs10504229 0.728 rs72650867 chr8:58154912 C/T cg11062466 chr8:58055876 NA 0.45 6.11 0.32 2.74e-9 Developmental language disorder (linguistic errors); CRC cis rs7412746 0.622 rs11552229 chr1:150783985 T/C cg10589385 chr1:150898437 SETDB1 0.31 6.48 0.34 3.38e-10 Melanoma; CRC cis rs3815700 1.000 rs8109768 chr19:33095463 A/G cg02997394 chr19:33096574 ANKRD27 0.73 8.31 0.42 2.61e-15 Eosinophilic esophagitis; CRC cis rs6674176 0.597 rs2352990 chr1:44393276 T/A cg12908607 chr1:44402522 ARTN -0.55 -9.69 -0.47 1.09e-19 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Cognitive ability; CRC cis rs7843479 0.601 rs1031882 chr8:21788934 T/G cg17168535 chr8:21777572 XPO7 0.66 11.06 0.52 2.17e-24 Mean corpuscular volume; CRC cis rs1150668 0.768 rs1233713 chr6:28198281 A/G cg15845792 chr6:28175446 NA 0.6 9.1 0.45 9.17e-18 Pubertal anthropometrics; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg01437395 chr2:110962594 NPHP1 0.48 6.83 0.35 4.07e-11 Response to antipsychotic treatment; CRC cis rs35306767 0.903 rs35968821 chr10:910225 A/G cg26597838 chr10:835615 NA 0.98 12.1 0.55 4.02e-28 Eosinophil percentage of granulocytes; CRC cis rs860295 0.812 rs10908481 chr1:155713650 T/G cg02153340 chr1:155202674 NA -0.52 -6.37 -0.33 6.21e-10 Body mass index; CRC cis rs9300255 0.620 rs1727311 chr12:123660716 T/G cg00376283 chr12:123451042 ABCB9 0.58 6.65 0.34 1.22e-10 Neutrophil percentage of white cells; CRC cis rs7107174 1.000 rs2511187 chr11:77985849 T/A cg02023728 chr11:77925099 USP35 0.51 7.36 0.38 1.53e-12 Testicular germ cell tumor; CRC cis rs1003719 0.715 rs2835647 chr21:38546773 C/T cg10648535 chr21:38446584 PIGP;TTC3 -0.48 -6.67 -0.35 1.08e-10 Eye color traits; CRC cis rs76878669 0.561 rs1892940 chr11:66111251 A/G cg24851651 chr11:66362959 CCS 0.39 6.78 0.35 5.6e-11 Educational attainment (years of education); CRC trans rs931812 0.691 rs884488 chr8:101898523 C/G cg20993868 chr7:22813445 NA 0.42 8.34 0.42 2.09e-15 Attention deficit hyperactivity disorder and conduct disorder; CRC cis rs734999 0.545 rs12730932 chr1:2559589 T/G cg20673091 chr1:2541236 MMEL1 -0.38 -6.05 -0.32 4e-9 Ulcerative colitis; CRC cis rs6121246 0.865 rs77130187 chr20:30269060 G/A cg13852791 chr20:30311386 BCL2L1 0.63 8.39 0.42 1.45e-15 Mean corpuscular hemoglobin; CRC cis rs9443189 0.570 rs523465 chr6:76330434 G/C cg01950844 chr6:76311363 SENP6 0.75 10.01 0.48 9.2e-21 Prostate cancer; CRC cis rs965469 0.843 rs6037580 chr20:3351374 A/G cg25506879 chr20:3388711 C20orf194 -0.4 -5.83 -0.31 1.35e-8 IFN-related cytopenia; CRC cis rs2084637 1.000 rs34651745 chr11:122418046 A/G cg21585512 chr11:122030076 LOC399959 -0.37 -6.59 -0.34 1.74e-10 Stroke; CRC cis rs7772486 0.790 rs2247666 chr6:146220409 C/A cg23711669 chr6:146136114 FBXO30 0.72 12.75 0.57 1.61e-30 Lobe attachment (rater-scored or self-reported); CRC cis rs62229266 0.771 rs2835232 chr21:37393427 G/A cg08632701 chr21:37451849 NA -0.42 -6.6 -0.34 1.68e-10 Mitral valve prolapse; CRC cis rs4474465 0.688 rs4457782 chr11:78284733 A/G cg27205649 chr11:78285834 NARS2 0.51 6.64 0.34 1.3e-10 Alzheimer's disease (survival time); CRC cis rs6751744 0.514 rs12386214 chr2:160531523 C/T cg08347373 chr2:160653686 CD302 -0.37 -6.08 -0.32 3.32e-9 Dysphagia; CRC cis rs7666738 0.791 rs11097601 chr4:98960103 C/T cg17366294 chr4:99064904 C4orf37 0.43 7.23 0.37 3.44e-12 Colonoscopy-negative controls vs population controls; CRC cis rs875971 0.965 rs697968 chr7:65535033 G/A cg00343986 chr7:65444356 GUSB -0.47 -6.94 -0.36 2.05e-11 Aortic root size; CRC cis rs4481887 0.676 rs6691314 chr1:248548020 G/A cg00666640 chr1:248458726 OR2T12 0.42 7.7 0.39 1.61e-13 Common traits (Other); CRC trans rs61931739 0.534 rs7965503 chr12:34199349 A/G cg26384229 chr12:38710491 ALG10B 0.54 6.87 0.35 3.22e-11 Morning vs. evening chronotype; CRC cis rs7811142 0.830 rs11768967 chr7:99967644 G/A cg00814883 chr7:100076585 TSC22D4 -0.68 -8.64 -0.43 2.57e-16 Platelet count; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg24524451 chr7:140372725 ADCK2 0.39 6.42 0.33 4.73e-10 Liver disease severity in Alagille syndrome; CRC cis rs4711336 0.935 rs754404 chr6:33664730 T/C cg14003231 chr6:33640908 ITPR3 0.44 7.22 0.37 3.69e-12 Height; CRC cis rs7615952 0.641 rs61048217 chr3:125807905 G/T cg05084668 chr3:125655381 ALG1L -0.46 -6.58 -0.34 1.91e-10 Blood pressure (smoking interaction); CRC cis rs7264396 0.747 rs2425112 chr20:34319775 A/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.65 -10.73 -0.51 3.14e-23 Total cholesterol levels; CRC trans rs58688157 0.705 rs12795572 chr11:590999 G/A cg19188899 chr13:112838565 NA -0.43 -6.62 -0.34 1.42e-10 Systemic lupus erythematosus; CRC cis rs9381040 0.537 rs9462669 chr6:41013659 C/A cg03644281 chr6:41068752 NFYA;LOC221442 -0.43 -5.99 -0.31 5.47e-9 Alzheimer's disease (late onset); CRC trans rs9467711 0.659 rs72844462 chr6:26563864 A/C cg06606381 chr12:133084897 FBRSL1 -1.07 -7.41 -0.38 1.09e-12 Autism spectrum disorder or schizophrenia; CRC cis rs9463078 0.683 rs227848 chr6:44698499 G/A cg25276700 chr6:44698697 NA 0.25 5.93 0.31 7.68e-9 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; CRC cis rs12594515 0.967 rs11857628 chr15:45998206 C/T cg22117107 chr15:45993392 NA -0.41 -8.19 -0.41 5.87e-15 Waist circumference;Weight; CRC cis rs7267979 0.844 rs2257649 chr20:25263457 T/G cg24626310 chr20:25276739 ABHD12;PYGB 0.35 5.82 0.31 1.37e-8 Liver enzyme levels (alkaline phosphatase); CRC cis rs10771431 0.935 rs1117735 chr12:9372728 G/A cg08997352 chr12:9597637 DDX12 -0.42 -6.13 -0.32 2.51e-9 Breast size; CRC trans rs7267979 1.000 rs2184000 chr20:25395878 G/A cg17903999 chr18:56338584 MALT1 0.41 6.9 0.36 2.62e-11 Liver enzyme levels (alkaline phosphatase); CRC cis rs12024301 0.557 rs12033293 chr1:183640422 A/G cg11505048 chr1:183622726 RGL1;APOBEC4 0.81 7.06 0.36 1.01e-11 Peripheral arterial disease (traffic-related air pollution interaction); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg05926606 chr21:40685342 BRWD1 0.44 7.25 0.37 3e-12 Liver disease severity in Alagille syndrome; CRC cis rs7937682 0.961 rs552387 chr11:111490047 T/G cg09085632 chr11:111637200 PPP2R1B -0.98 -19.2 -0.73 1.2e-55 Primary sclerosing cholangitis; CRC cis rs6752107 1.000 rs10165561 chr2:234172915 G/C cg07618928 chr2:234183455 ATG16L1;SCARNA5 0.66 11.42 0.53 1.14e-25 Crohn's disease;Inflammatory bowel disease; CRC cis rs9303280 0.776 rs11078926 chr17:38062976 G/A cg00129232 chr17:37814104 STARD3 -0.48 -7.54 -0.38 4.65e-13 Self-reported allergy; CRC cis rs4523957 0.928 rs9899193 chr17:2156917 G/A cg16513277 chr17:2031491 SMG6 0.52 8.77 0.44 9.5e-17 Autism spectrum disorder or schizophrenia;Schizophrenia; CRC cis rs861020 0.630 rs656566 chr1:210006603 C/T cg05527609 chr1:210001259 C1orf107 0.77 10.66 0.51 5.37e-23 Orofacial clefts; CRC trans rs2727020 0.729 rs10839283 chr11:49490943 T/C cg03929089 chr4:120376271 NA 0.8 12.19 0.56 1.84e-28 Coronary artery disease; CRC cis rs2985684 0.846 rs10150624 chr14:50051565 A/G cg04989706 chr14:50066350 PPIL5 -0.62 -8.8 -0.44 7.77e-17 Carotid intima media thickness; CRC cis rs7587476 0.643 rs6714373 chr2:215719014 A/G cg04004882 chr2:215674386 BARD1 0.64 8.8 0.44 7.96e-17 Neuroblastoma; CRC cis rs4604732 0.631 rs12031721 chr1:247623773 G/A cg02104434 chr1:247694406 LOC148824;OR2C3 0.6 8.47 0.42 8.36e-16 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CRC cis rs1862618 0.573 rs1550821 chr5:56242323 C/T cg12311346 chr5:56204834 C5orf35 0.9 12.76 0.58 1.44e-30 Initial pursuit acceleration; CRC cis rs17711722 0.565 rs4717276 chr7:65294741 G/T cg07294406 chr7:64700536 NA 0.37 6.02 0.32 4.57e-9 Calcium levels; CRC cis rs4713118 0.629 rs203890 chr6:28022248 T/C cg06470822 chr6:28175283 NA 0.94 13.58 0.6 1.16e-33 Parkinson's disease; CRC cis rs798554 0.610 rs1182209 chr7:2808595 C/T cg04166393 chr7:2884313 GNA12 0.38 5.74 0.3 2.2e-8 Height; CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg10201608 chr2:85788586 GGCX -0.55 -6.7 -0.35 9.05e-11 Diisocyanate-induced asthma; CRC cis rs3823572 0.564 rs2971962 chr7:133639770 G/A cg03336402 chr7:133662267 EXOC4 0.67 10.04 0.48 7.53e-21 Intelligence (multi-trait analysis); CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg00873937 chr10:69991564 ATOH7 0.45 6.04 0.32 4.16e-9 Thyroid stimulating hormone; CRC cis rs8062405 0.755 rs4788074 chr16:28593597 A/G cg16576597 chr16:28551801 NUPR1 -0.55 -8.29 -0.42 2.9e-15 Cognitive ability (multi-trait analysis);Cognitive ability; CRC trans rs7819412 0.521 rs9329238 chr8:11033737 C/T cg06636001 chr8:8085503 FLJ10661 -0.46 -6.64 -0.34 1.3100000000000001e-10 Triglycerides; CRC cis rs4285028 0.948 rs35737776 chr3:121677856 G/A cg20356878 chr3:121714668 ILDR1 -0.48 -6.95 -0.36 1.93e-11 Multiple sclerosis; CRC cis rs713587 0.563 rs10865315 chr2:25100738 C/A cg22495460 chr2:25135724 ADCY3 -0.86 -16.36 -0.67 1.88e-44 Body mass index in non-asthmatics; CRC cis rs2730260 0.736 rs73169220 chr7:158846197 A/C cg02254261 chr7:158964346 NA -0.56 -6.2 -0.32 1.68e-9 Myopia (pathological); CRC cis rs1065852 0.526 rs739296 chr22:42389948 A/G cg00645731 chr22:42541494 CYP2D7P1 -0.39 -6.85 -0.35 3.56e-11 Response to serotonin reuptake inhibitors in major depressive disorder (plasma drug and metabolite levels); CRC cis rs1129187 0.967 rs3805952 chr6:42937126 C/T cg02359409 chr6:42947317 PEX6 -0.59 -9.23 -0.45 3.5e-18 Alzheimer's disease in APOE e4+ carriers; CRC cis rs4853012 0.838 rs4429500 chr2:74345336 A/G cg20891558 chr2:74357851 NA 0.57 9.12 0.45 7.74e-18 Gestational age at birth (maternal effect); CRC cis rs10197940 0.578 rs2432946 chr2:152306897 G/T cg06191203 chr2:152266755 RIF1 0.45 6.31 0.33 8.94e-10 Lung cancer; CRC cis rs10991814 0.920 rs75779763 chr9:94060031 G/A cg14446406 chr9:93919335 NA 0.5 5.99 0.31 5.45e-9 Neutrophil percentage of granulocytes; CRC cis rs9616064 0.531 rs867212 chr22:47063330 C/T cg05621596 chr22:47072043 GRAMD4 0.75 12.61 0.57 5.12e-30 Urate levels in obese individuals; CRC cis rs225245 0.755 rs6505493 chr17:34028901 A/G cg05299278 chr17:33885742 SLFN14 0.51 8.22 0.41 4.9e-15 Reticulocyte count;Reticulocyte fraction of red cells;High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells; CRC cis rs9322193 0.923 rs9800686 chr6:149955600 A/C cg00933542 chr6:150070202 PCMT1 0.31 6.23 0.33 1.4e-9 Lung cancer; CRC cis rs1003719 0.788 rs4572679 chr21:38453227 T/C cg10648535 chr21:38446584 PIGP;TTC3 0.51 7.26 0.37 2.81e-12 Eye color traits; CRC cis rs67478160 0.608 rs34066659 chr14:104263427 A/C cg08213375 chr14:104286397 PPP1R13B 0.63 13.35 0.59 8.5e-33 Schizophrenia; CRC trans rs1814175 0.935 rs10839329 chr11:49694206 G/A cg03929089 chr4:120376271 NA -0.94 -17.26 -0.69 5.33e-48 Height; CRC cis rs7572644 0.656 rs34096628 chr2:28060990 A/C cg27432699 chr2:27873401 GPN1 0.45 6.11 0.32 2.79e-9 Response to carboplatin and paclitaxel in ovarian cancer (Caspase 3/7 EC50); CRC cis rs1552244 1.000 rs113134644 chr3:10086286 G/A cg16606324 chr3:10149918 C3orf24 0.69 9.52 0.46 3.91e-19 Alzheimer's disease; CRC trans rs7647973 0.626 rs11709734 chr3:49745235 G/A cg21665057 chr3:196295764 WDR53;FBXO45 -0.61 -6.87 -0.35 3.25e-11 Menarche (age at onset); CRC cis rs6961069 0.933 rs7807607 chr7:80226885 C/T cg04458919 chr7:80252533 CD36 -0.33 -5.75 -0.3 2.06e-8 Platelet count; CRC cis rs853679 0.517 rs4713135 chr6:28039586 G/A cg21251018 chr6:28226885 NKAPL 0.46 6.12 0.32 2.73e-9 Depression; CRC cis rs10504229 0.906 rs111838497 chr8:58185620 A/C cg24829409 chr8:58192753 C8orf71 -0.68 -11.34 -0.53 2.27e-25 Developmental language disorder (linguistic errors); CRC cis rs6570726 0.967 rs403584 chr6:145807010 G/A cg23711669 chr6:146136114 FBXO30 0.62 10.7 0.51 4.1000000000000003e-23 Lobe attachment (rater-scored or self-reported); CRC cis rs1401999 0.690 rs6773408 chr3:183716609 G/T cg01324343 chr3:183735012 ABCC5 0.7 12.63 0.57 4.54e-30 Anterior chamber depth; CRC cis rs2032447 0.966 rs9358901 chr6:26024436 G/T cg27635394 chr6:26043820 HIST1H2BB 0.4 6.09 0.32 3.11e-9 Intelligence (multi-trait analysis); CRC cis rs9648716 1.000 rs6948703 chr7:140584438 T/C cg10747023 chr7:140774559 NA 0.44 5.88 0.31 9.82e-9 Type 2 diabetes; CRC cis rs4234798 0.585 rs13121616 chr4:7212389 A/G cg18431297 chr4:7219810 SORCS2 0.47 7.35 0.38 1.54e-12 Insulin-like growth factors; CRC cis rs12971120 0.891 rs71359051 chr18:72169723 G/A cg25817165 chr18:72167213 CNDP2 -0.65 -9.03 -0.45 1.43e-17 Refractive error; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg21843114 chr4:26334859 RBPJ -0.39 -6.39 -0.33 5.82e-10 Liver disease severity in Alagille syndrome; CRC cis rs2032447 0.714 rs2051540 chr6:25947197 T/C cg15691649 chr6:25882328 NA -0.42 -5.62 -0.3 4.04e-8 Intelligence (multi-trait analysis); CRC cis rs6700896 0.864 rs11208691 chr1:66092570 A/G cg04111102 chr1:66153794 NA 0.33 5.81 0.31 1.48e-8 C-reactive protein;Mean corpuscular volume;Mean corpuscular hemoglobin; CRC cis rs4664293 0.867 rs2357531 chr2:160597418 G/A cg08347373 chr2:160653686 CD302 -0.47 -7.43 -0.38 9.32e-13 Monocyte percentage of white cells; CRC cis rs684232 0.602 rs331010 chr17:547124 G/A cg15660573 chr17:549704 VPS53 -0.86 -15.78 -0.66 3.56e-42 Prostate cancer; CRC cis rs9914988 0.943 rs9902953 chr17:27139834 C/A cg07195577 chr17:27052828 TLCD1 0.42 6.01 0.31 4.85e-9 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs3858526 0.606 rs10838883 chr11:5952147 G/A cg26762873 chr11:5879799 OR52E8 0.42 7.11 0.37 7.18e-12 DNA methylation (variation); CRC cis rs9392556 0.533 rs619439 chr6:4113929 G/A cg10424681 chr6:4079350 C6orf201;C6orf146 0.24 6.07 0.32 3.52e-9 Blood metabolite levels; CRC cis rs11690935 0.959 rs4667694 chr2:172605399 G/A cg13550731 chr2:172543902 DYNC1I2 -1.06 -16.8 -0.68 3.44e-46 Schizophrenia; CRC cis rs798554 0.757 rs1183085 chr7:2875570 G/A cg14895029 chr7:2775587 GNA12 -0.42 -6.04 -0.32 4.19e-9 Height; CRC cis rs2692947 0.696 rs2969490 chr2:96803904 A/G cg23100626 chr2:96804247 ASTL 0.27 7.58 0.39 3.62e-13 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; CRC cis rs7666738 0.761 rs28758886 chr4:99059704 C/T cg17366294 chr4:99064904 C4orf37 0.45 7.71 0.39 1.51e-13 Colonoscopy-negative controls vs population controls; CRC cis rs59043219 1 rs59043219 chr1:209970610 G/A cg23283495 chr1:209979779 IRF6 0.58 11.27 0.53 3.84e-25 Crohn's disease;Inflammatory bowel disease;Alzheimer's disease (APOE e4 interaction); CRC cis rs2243480 0.908 rs4718273 chr7:65216099 G/A cg12463550 chr7:65579703 CRCP -0.67 -6.26 -0.33 1.21e-9 Diabetic kidney disease; CRC cis rs6952808 0.717 rs12534679 chr7:1926745 G/A cg02951883 chr7:2050386 MAD1L1 -0.57 -9.45 -0.46 6.37e-19 Bipolar disorder and schizophrenia; CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg08679808 chr17:79886116 LOC92659;MAFG 0.37 5.99 0.31 5.38e-9 Obesity-related traits; CRC cis rs6866344 0.697 rs17184281 chr5:178127563 G/A cg10224037 chr5:178157518 ZNF354A 0.79 11.59 0.54 2.72e-26 Neutrophil percentage of white cells; CRC cis rs11229555 0.645 rs11229463 chr11:58210147 A/G cg15696309 chr11:58395628 NA -0.82 -10.31 -0.49 8.59e-22 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; CRC cis rs10504229 0.683 rs59679713 chr8:58134370 G/C cg04204079 chr8:58130323 NA -0.44 -5.71 -0.3 2.52e-8 Developmental language disorder (linguistic errors); CRC cis rs6496667 0.779 rs8042913 chr15:91023147 G/C cg04176472 chr15:90893244 GABARAPL3 0.53 7.87 0.4 5.19e-14 Rheumatoid arthritis; CRC cis rs4930561 0.765 rs10896304 chr11:67981714 T/G cg16338278 chr11:67432957 ALDH3B2 0.4 5.7 0.3 2.64e-8 Breast cancer in childhood cancer survivors;IgG glycosylation; CRC trans rs11722228 0.508 rs3756227 chr4:10087995 C/A cg26043149 chr18:55253948 FECH 1.06 16.7 0.68 8.9e-46 Gout;Urate levels;Serum uric acid levels; CRC cis rs875971 0.660 rs3764903 chr7:66098482 G/A cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.43 -6.4 -0.33 5.21e-10 Aortic root size; CRC cis rs12541635 0.966 rs4416800 chr8:106996677 T/C cg10147462 chr8:107024639 NA 0.43 7.1 0.36 7.51e-12 Age of smoking initiation; CRC cis rs3772130 1.000 rs56314138 chr3:121356656 G/A cg20356878 chr3:121714668 ILDR1 0.49 7.65 0.39 2.22e-13 Cognitive performance; CRC cis rs9517320 0.534 rs9556963 chr13:99157026 G/A cg20487152 chr13:99095054 FARP1 -0.47 -6.68 -0.35 1.02e-10 Longevity; CRC cis rs391936 0.568 rs3102955 chr2:8467647 C/T cg12167548 chr2:8464763 NA 0.32 5.96 0.31 6.34e-9 Selective IgA deficiency; CRC cis rs1215050 0.755 rs6843393 chr4:98822619 C/G cg05340658 chr4:99064831 C4orf37 0.47 6.9 0.36 2.68e-11 Waist-to-hip ratio adjusted for body mass index; CRC cis rs10504229 0.683 rs56741275 chr8:58136108 C/G cg02725872 chr8:58115012 NA -0.64 -11.55 -0.54 3.85e-26 Developmental language disorder (linguistic errors); CRC cis rs853679 0.760 rs9393909 chr6:28207200 A/G cg06470822 chr6:28175283 NA -0.6 -5.9 -0.31 9.06e-9 Depression; CRC cis rs860295 0.665 rs11264367 chr1:155337338 T/C cg02153340 chr1:155202674 NA -0.57 -6.76 -0.35 6.48e-11 Body mass index; CRC cis rs59104589 0.570 rs3771569 chr2:242382606 A/T cg19488206 chr2:242435732 STK25 0.45 6.75 0.35 6.88e-11 Fibrinogen levels; CRC cis rs644799 1.000 rs10831431 chr11:95510089 C/T cg25478527 chr11:95522999 CEP57;FAM76B 0.53 7.88 0.4 4.93e-14 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs853679 0.542 rs9393892 chr6:28081394 A/G cg23161317 chr6:28129485 ZNF389 0.54 6.62 0.34 1.48e-10 Depression; CRC trans rs3806843 0.900 rs2531340 chr5:140131046 C/T cg06840491 chr10:48416966 GDF2 -0.35 -6.04 -0.32 4.16e-9 Depressive symptoms (multi-trait analysis); CRC trans rs9291683 0.595 rs13145442 chr4:10037261 C/A cg26043149 chr18:55253948 FECH 0.53 8.16 0.41 7.05e-15 Bone mineral density; CRC cis rs9322193 0.923 rs11155683 chr6:150100477 T/C cg00933542 chr6:150070202 PCMT1 0.28 5.63 0.3 3.86e-8 Lung cancer; CRC cis rs6598955 0.614 rs1134584 chr1:26608828 G/A cg00852783 chr1:26633632 UBXN11 0.41 6.72 0.35 7.92e-11 Obesity-related traits; CRC cis rs533581 0.866 rs2968474 chr16:88970566 A/G cg16701003 chr16:89028210 CBFA2T3 -0.43 -6.62 -0.34 1.46e-10 Social autistic-like traits; CRC cis rs7615952 0.599 rs2333408 chr3:125732098 G/A cg06494592 chr3:125709126 NA -0.52 -6.65 -0.34 1.23e-10 Blood pressure (smoking interaction); CRC cis rs7607369 0.714 rs4674334 chr2:219622811 T/C cg02176678 chr2:219576539 TTLL4 -0.57 -9.02 -0.45 1.61e-17 Red blood cell count;Amyotrophic lateral sclerosis; CRC cis rs7618915 0.547 rs34215106 chr3:52659124 T/C cg05573699 chr3:52720067 GNL3;PBRM1 -0.46 -6.59 -0.34 1.76e-10 Bipolar disorder; CRC cis rs17767392 0.846 rs34281934 chr14:71979756 C/T cg13720639 chr14:72061746 SIPA1L1 -0.49 -6.4 -0.33 5.31e-10 Mitral valve prolapse; CRC cis rs1267303 0.600 rs57100184 chr1:47004710 A/C cg25110126 chr1:46999211 NA 0.61 8.59 0.43 3.63e-16 Monobrow; CRC cis rs9487051 0.676 rs7773213 chr6:109601885 C/T cg12927641 chr6:109611667 NA -0.38 -6.61 -0.34 1.51e-10 Reticulocyte fraction of red cells; CRC cis rs1448094 0.527 rs59445394 chr12:86237843 C/T cg18827107 chr12:86230957 RASSF9 -0.5 -8.1 -0.41 1.1e-14 Major depressive disorder; CRC cis rs2842992 0.672 rs7738253 chr6:160193917 G/T cg11366901 chr6:160182831 ACAT2 0.94 13.28 0.59 1.62e-32 Age-related macular degeneration (geographic atrophy); CRC cis rs3617 0.591 rs11918800 chr3:52868145 G/A cg07507251 chr3:52567010 NT5DC2 -0.4 -6.2 -0.32 1.66e-9 Red blood cell count;Autism spectrum disorder or schizophrenia; CRC trans rs2303319 0.582 rs56315911 chr2:162560186 G/T cg09481857 chr22:21368659 P2RX6;MGC16703 -0.61 -5.99 -0.31 5.62e-9 Cognitive function; CRC cis rs1707322 1.000 rs6429580 chr1:46275648 A/G cg03146154 chr1:46216737 IPP 0.52 7.25 0.37 3.04e-12 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs6938 0.575 rs12909335 chr15:75214789 T/G cg09165964 chr15:75287851 SCAMP5 0.58 9.08 0.45 1.01e-17 Breast cancer; CRC cis rs950169 0.922 rs6603022 chr15:84830170 T/C cg11189052 chr15:85197271 WDR73 -0.59 -8.26 -0.41 3.66e-15 Schizophrenia; CRC cis rs9875589 0.957 rs1579551 chr3:13945571 C/G cg14375111 chr3:14165186 TMEM43;CHCHD4 0.39 5.72 0.3 2.38e-8 Ovarian reserve; CRC cis rs2933343 0.818 rs6764681 chr3:128568380 G/C cg11901034 chr3:128598214 ACAD9 0.47 5.65 0.3 3.53e-8 IgG glycosylation; CRC cis rs758324 0.812 rs477086 chr5:131284610 C/T cg25547332 chr5:131281432 NA -0.37 -5.89 -0.31 9.7e-9 Alzheimer's disease in APOE e4- carriers; CRC cis rs995000 0.899 rs1168030 chr1:62968491 C/T cg19896129 chr1:63156450 NA -0.39 -6.08 -0.32 3.29e-9 Triglyceride levels; CRC cis rs9303280 0.901 rs2313430 chr17:37929816 T/C cg00129232 chr17:37814104 STARD3 0.42 6.74 0.35 7.2e-11 Self-reported allergy; CRC cis rs7542091 0.579 rs34638782 chr1:210032055 C/G cg22029157 chr1:209979665 IRF6 0.47 7.35 0.38 1.57e-12 Monobrow; CRC trans rs9693857 0.520 rs4841163 chr8:9366178 C/G cg06636001 chr8:8085503 FLJ10661 0.47 6.35 0.33 7e-10 Systolic blood pressure; CRC cis rs73206853 0.841 rs73191816 chr12:110918564 G/A cg12870014 chr12:110450643 ANKRD13A 0.81 8.45 0.42 9.43e-16 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC cis rs6502050 0.835 rs4499294 chr17:80148346 C/T cg09264619 chr17:80180166 NA -0.37 -6.17 -0.32 2.04e-9 Life satisfaction; CRC cis rs9487051 0.714 rs7757347 chr6:109633815 G/A cg21918786 chr6:109611834 NA -0.4 -7.0 -0.36 1.47e-11 Reticulocyte fraction of red cells; CRC cis rs60871478 0.636 rs55663559 chr7:884057 G/A cg13844804 chr7:814759 HEATR2 -0.58 -6.16 -0.32 2.08e-9 Cerebrospinal P-tau181p levels; CRC cis rs1448094 0.872 rs12322940 chr12:86406708 G/C cg02569458 chr12:86230093 RASSF9 0.39 6.55 0.34 2.25e-10 Major depressive disorder; CRC cis rs11690935 1.000 rs3795999 chr2:172544483 A/G cg13550731 chr2:172543902 DYNC1I2 1.09 18.65 0.72 1.74e-53 Schizophrenia; CRC cis rs9916302 0.861 rs10491129 chr17:37461643 T/G cg07936489 chr17:37558343 FBXL20 0.77 11.46 0.53 7.98e-26 Glomerular filtration rate (creatinine); CRC trans rs7976838 0.908 rs34272110 chr12:60122507 T/C cg16974014 chr22:22007515 MIR130B 0.49 6.0 0.31 5.21e-9 Response to zileuton treatment in asthma (FEV1 change interaction); CRC trans rs7821565 0.904 rs66892367 chr8:52177170 T/C cg09187163 chr7:72721838 NSUN5 -0.41 -5.98 -0.31 5.7e-9 Tuberculosis; CRC cis rs11719291 0.504 rs34571182 chr3:49209057 T/A cg07636037 chr3:49044803 WDR6 -0.66 -5.7 -0.3 2.62e-8 Cognitive function; CRC cis rs801193 0.636 rs10233806 chr7:66118248 G/C cg18876405 chr7:65276391 NA -0.51 -8.43 -0.42 1.07e-15 Aortic root size; CRC cis rs7412746 0.658 rs1546376 chr1:150937661 A/G cg15448220 chr1:150897856 SETDB1 0.57 8.23 0.41 4.5e-15 Melanoma; CRC trans rs12301672 0.774 rs7297794 chr12:75540498 A/G cg16347928 chr1:854838 FLJ39609 0.44 6.18 0.32 1.84e-9 Colonoscopy-negative controls vs population controls; CRC cis rs9381040 0.655 rs2268187 chr6:41042993 G/A cg25110423 chr6:41068646 NFYA;LOC221442 -0.39 -5.97 -0.31 6.04e-9 Alzheimer's disease (late onset); CRC cis rs10924970 0.649 rs4659493 chr1:235482272 T/C cg09010748 chr1:235293032 TOMM20 -0.4 -5.65 -0.3 3.57e-8 Asthma; CRC cis rs4563143 0.514 rs112540771 chr19:29316100 C/T cg12756686 chr19:29218302 NA 0.6 8.24 0.41 4.11e-15 Methadone dose in opioid dependence; CRC trans rs10982213 0.830 rs2274163 chr9:117188714 C/T cg10117518 chr2:29117384 WDR43 0.39 6.05 0.32 3.87e-9 Interleukin-6 levels; CRC cis rs3996993 0.597 rs72938158 chr6:52735179 T/A cg20803780 chr6:52668592 GSTA1 0.39 6.6 0.34 1.61e-10 Hemoglobin concentration; CRC cis rs875971 0.862 rs709596 chr7:65825913 A/G cg00343986 chr7:65444356 GUSB 0.4 5.68 0.3 3.01e-8 Aortic root size; CRC cis rs2404602 0.716 rs56216512 chr15:76686936 T/C cg22467129 chr15:76604101 ETFA -0.44 -7.44 -0.38 9.04e-13 Blood metabolite levels; CRC cis rs7044106 0.664 rs7861679 chr9:123375589 A/G cg09419670 chr9:123605666 PSMD5;LOC253039 -0.65 -10.68 -0.51 4.71e-23 Hip circumference adjusted for BMI; CRC cis rs13392177 0.660 rs10932762 chr2:219076213 G/C cg00012203 chr2:219082015 ARPC2 -0.49 -7.18 -0.37 4.66e-12 Pyoderma gangrenosum in inflammatory bowel disease; CRC cis rs7917772 0.582 rs11191352 chr10:104372244 A/G cg11453585 chr10:104263688 ACTR1A;SUFU 0.83 15.21 0.64 6.05e-40 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC cis rs6543140 0.855 rs4851591 chr2:103077423 T/C cg09003973 chr2:102972529 NA 0.41 5.83 0.31 1.33e-8 Blood protein levels; CRC cis rs875971 0.545 rs73376401 chr7:65639828 G/A cg03233332 chr7:66118400 NA -0.45 -6.35 -0.33 6.98e-10 Aortic root size; CRC cis rs1832871 0.672 rs9456289 chr6:158740347 G/A cg07165851 chr6:158734300 TULP4 0.63 7.96 0.4 2.75e-14 Height; CRC cis rs2721195 0.967 rs748195 chr8:145682514 T/C cg15857475 chr8:145742913 RECQL4;LRRC14 0.69 11.29 0.53 3.24e-25 Age at first birth; CRC cis rs710216 0.843 rs10890232 chr1:43416514 C/T cg03128534 chr1:43423976 SLC2A1 0.48 6.4 0.33 5.27e-10 Red cell distribution width; CRC trans rs7615952 0.932 rs13314869 chr3:125644669 G/A cg21747405 chr11:67723411 NA -0.44 -6.25 -0.33 1.31e-9 Blood pressure (smoking interaction); CRC cis rs6502050 0.835 rs11658335 chr17:80084821 C/T cg25804541 chr17:80189381 SLC16A3 0.31 5.9 0.31 8.94e-9 Life satisfaction; CRC cis rs6961069 0.806 rs4728183 chr7:80256003 A/G cg04458919 chr7:80252533 CD36 0.36 6.23 0.32 1.43e-9 Platelet count; CRC cis rs9322193 0.962 rs9393175 chr6:149998723 A/G cg05861140 chr6:150128134 PCMT1 -0.38 -5.94 -0.31 7.44e-9 Lung cancer; CRC cis rs9399137 0.507 rs11754021 chr6:135308375 A/G cg22676075 chr6:135203613 NA 0.59 8.94 0.44 2.77e-17 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; CRC trans rs4684776 0.548 rs62248289 chr3:11637907 T/C cg20302342 chr1:156215951 PAQR6 -0.48 -6.31 -0.33 9e-10 Small vessel stroke; CRC cis rs12893668 0.703 rs7148456 chr14:104028270 C/T cg08213375 chr14:104286397 PPP1R13B -0.36 -5.82 -0.31 1.44e-8 Reticulocyte count; CRC cis rs10971721 0.822 rs72725370 chr9:33818457 A/T cg13495928 chr9:33750294 PRSS3 0.55 5.89 0.31 9.66e-9 Body mass index; CRC cis rs6088590 0.931 rs6088617 chr20:33408036 G/A cg08999081 chr20:33150536 PIGU 0.5 8.65 0.43 2.28e-16 Coronary artery disease; CRC trans rs2303319 0.504 rs62189043 chr2:162608466 A/T cg13490827 chr1:46269305 MAST2 -0.69 -6.0 -0.31 5.24e-9 Cognitive function; CRC cis rs3789045 0.560 rs1002779 chr1:204405098 T/A cg17419461 chr1:204415978 PIK3C2B -0.81 -10.79 -0.51 2.01e-23 Educational attainment (college completion); CRC cis rs13191362 0.872 rs13196631 chr6:163001588 A/G cg21926612 chr6:163149169 PACRG;PARK2 0.82 11.39 0.53 1.52e-25 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs11711311 0.911 rs9831422 chr3:113398195 G/A cg15478005 chr3:113465772 ATP6V1A;NAA50 0.46 6.09 0.32 3.16e-9 IgG glycosylation; CRC cis rs7493 0.950 rs6961624 chr7:95037661 T/C cg21856205 chr7:94953877 PON1 -0.49 -6.44 -0.33 4.12e-10 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs1838105 0.674 rs1634260 chr17:45174285 G/A cg16759221 chr17:45003025 GOSR2 -0.61 -9.17 -0.45 5.35e-18 Nonsyndromic cleft lip with cleft palate; CRC cis rs10193935 1.000 rs13424523 chr2:42413562 T/G cg27598129 chr2:42591480 NA -0.71 -8.3 -0.42 2.69e-15 Colonoscopy-negative controls vs population controls; CRC cis rs6988985 0.818 rs6471583 chr8:143991092 G/A cg10324643 chr8:143916377 GML 0.37 5.93 0.31 7.76e-9 Plasma androstenedione levels in resected early stage-receptor positive breast cancer; CRC cis rs7811142 1.000 rs113738841 chr7:100081306 C/T cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.16 17.05 0.68 3.64e-47 Platelet count; CRC cis rs17331151 0.573 rs2240916 chr3:52859212 T/A cg06204229 chr3:52865917 ITIH4 0.57 7.88 0.4 4.95e-14 Immune reponse to smallpox (secreted IL-2); CRC cis rs9443189 0.950 rs6453845 chr6:76576527 G/T cg01950844 chr6:76311363 SENP6 -0.62 -7.46 -0.38 7.93e-13 Prostate cancer; CRC cis rs6951245 0.529 rs76001997 chr7:1152615 C/T cg22907277 chr7:1156413 C7orf50 0.81 10.39 0.5 4.81e-22 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs4555082 0.756 rs76863138 chr14:105736379 C/T cg13114125 chr14:105738426 BRF1 -0.8 -11.62 -0.54 2.28e-26 Mean platelet volume;Platelet distribution width; CRC cis rs9309473 0.607 rs2421489 chr2:73593448 A/G cg20560298 chr2:73613845 ALMS1 -0.49 -6.6 -0.34 1.67e-10 Metabolite levels; CRC cis rs763121 0.853 rs5750669 chr22:39080638 T/A cg06022373 chr22:39101656 GTPBP1 0.77 11.74 0.54 8.16e-27 Menopause (age at onset); CRC cis rs6681460 0.966 rs6588215 chr1:67141949 A/G cg02459107 chr1:67143332 SGIP1 0.5 9.0 0.44 1.83e-17 Presence of antiphospholipid antibodies; CRC cis rs1691799 0.899 rs1168299 chr12:66736074 C/G cg16791601 chr12:66731901 HELB -0.73 -12.61 -0.57 5.09e-30 White blood cell count (basophil); CRC cis rs875971 1.000 rs709595 chr7:65817333 G/C cg00343986 chr7:65444356 GUSB 0.43 6.37 0.33 6.49e-10 Aortic root size; CRC cis rs9354308 0.933 rs2022856 chr6:66568235 G/T cg07460842 chr6:66804631 NA 0.47 5.92 0.31 8.03e-9 Metabolite levels; CRC cis rs2160860 0.585 rs11779697 chr8:39797735 C/T cg11363097 chr8:39792086 IDO2 -0.42 -7.25 -0.37 2.94e-12 Blood metabolite levels; CRC cis rs875971 0.964 rs1643388 chr7:65844562 T/C cg18912574 chr7:65842487 NCRNA00174 0.36 6.18 0.32 1.88e-9 Aortic root size; CRC cis rs7799006 0.527 rs73039284 chr7:2221583 C/G cg02951883 chr7:2050386 MAD1L1 -0.58 -8.32 -0.42 2.37e-15 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs7811142 1.000 rs60257855 chr7:100026780 G/C cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.17 17.34 0.69 2.56e-48 Platelet count; CRC cis rs7927771 0.832 rs7924485 chr11:47419129 A/G cg05585544 chr11:47624801 NA 0.54 9.5 0.46 4.38e-19 Subjective well-being; CRC cis rs1448094 0.556 rs17279916 chr12:86170647 G/A cg25456477 chr12:86230367 RASSF9 0.41 6.99 0.36 1.54e-11 Major depressive disorder; CRC trans rs10207628 0.941 rs11887884 chr2:127848041 C/T cg22628694 chr19:58663362 ZNF329 0.6 6.08 0.32 3.31e-9 Psychosis and Alzheimer's disease; CRC cis rs763014 1.000 rs763014 chr16:675680 T/C cg09263875 chr16:632152 PIGQ 0.8 12.73 0.57 1.89e-30 Height; CRC cis rs55665837 1.000 rs12295888 chr11:14450531 T/C cg19336497 chr11:14380999 RRAS2 -0.39 -6.64 -0.34 1.3100000000000001e-10 Vitamin D levels; CRC cis rs4964805 0.594 rs751448 chr12:104167185 C/T cg02344784 chr12:104178138 NT5DC3 0.41 6.14 0.32 2.39e-9 Attention deficit hyperactivity disorder; CRC cis rs2153535 0.580 rs7747306 chr6:8453663 C/G cg21535247 chr6:8435926 SLC35B3 -0.49 -7.55 -0.38 4.32e-13 Motion sickness; CRC cis rs1355223 0.525 rs12280958 chr11:34872799 G/A cg11058730 chr11:34937778 PDHX;APIP -0.43 -6.07 -0.32 3.51e-9 Systemic lupus erythematosus and Systemic sclerosis; CRC cis rs9649465 0.967 rs10224062 chr7:123304609 G/A cg03229431 chr7:123269106 ASB15 -0.37 -5.71 -0.3 2.56e-8 Migraine; CRC cis rs9547692 1.000 rs9547692 chr13:37473243 A/C cg01493522 chr13:37497338 NA -0.56 -7.61 -0.39 2.93e-13 Coronary artery disease; CRC cis rs1577917 1.000 rs12207610 chr6:86688016 A/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.51 -6.77 -0.35 5.76e-11 Response to antipsychotic treatment; CRC cis rs6582630 0.638 rs12425531 chr12:38550387 A/G cg13010199 chr12:38710504 ALG10B -0.42 -6.05 -0.32 3.97e-9 Drug-induced liver injury (flucloxacillin); CRC cis rs8062405 0.755 rs4788076 chr16:28570005 C/T cg05139728 chr16:28306816 SBK1 -0.37 -6.09 -0.32 3.19e-9 Cognitive ability (multi-trait analysis);Cognitive ability; CRC cis rs908922 0.651 rs564107 chr1:152519295 C/T cg23254163 chr1:152506842 NA 0.45 8.87 0.44 4.86e-17 Hair morphology; CRC cis rs2516839 0.605 rs12749496 chr1:161021893 G/C cg11161846 chr1:160990452 F11R -0.47 -7.18 -0.37 4.61e-12 Granulocyte percentage of myeloid white cells; CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg19355881 chr6:34759549 UHRF1BP1 0.39 6.27 0.33 1.14e-9 Obesity-related traits; CRC cis rs9926296 0.609 rs4785709 chr16:89796665 G/A cg03605463 chr16:89740564 NA 0.45 6.58 0.34 1.9e-10 Vitiligo; CRC cis rs5750830 0.649 rs4821894 chr22:39809820 G/C cg11247378 chr22:39784982 NA -0.41 -7.24 -0.37 3.12e-12 Intelligence (multi-trait analysis); CRC cis rs6598955 0.612 rs12738188 chr1:26548029 G/C cg04990556 chr1:26633338 UBXN11 -0.79 -13.27 -0.59 1.75e-32 Obesity-related traits; CRC cis rs1552244 0.706 rs279545 chr3:9972493 A/G cg18598329 chr3:10140678 FANCD2;C3orf24 -0.7 -10.31 -0.49 8.55e-22 Alzheimer's disease; CRC cis rs7659604 1.000 rs28433617 chr4:122664138 C/A cg19748678 chr4:122722346 EXOSC9 0.55 8.91 0.44 3.49e-17 Type 2 diabetes; CRC cis rs1506636 1.000 rs600774 chr7:123397831 C/T cg03229431 chr7:123269106 ASB15 0.7 10.92 0.52 6.71e-24 Plateletcrit;Platelet count; CRC cis rs3823572 0.542 rs11773892 chr7:133626334 G/T cg03336402 chr7:133662267 EXOC4 0.66 9.76 0.47 6.16e-20 Intelligence (multi-trait analysis); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg16271524 chr11:66139231 SLC29A2 0.41 6.02 0.31 4.71e-9 Response to antipsychotic treatment; CRC trans rs17111396 0.627 rs12100732 chr14:81506485 G/C cg22745369 chr6:3517953 NA -0.43 -6.04 -0.32 4.17e-9 Uric acid levels; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg03509965 chr14:75743987 FOS 0.39 6.09 0.32 3.09e-9 Intelligence (multi-trait analysis); CRC trans rs6550704 0.687 rs9865314 chr3:22634337 A/G cg18652453 chr5:68665041 TAF9;RAD17 -0.46 -7.09 -0.36 8.46e-12 Daytime sleep phenotypes; CRC cis rs2842992 0.768 rs2273824 chr6:160211445 C/T cg19482086 chr6:160211437 TCP1;MRPL18 0.84 13.53 0.6 1.75e-33 Age-related macular degeneration (geographic atrophy); CRC trans rs2840044 1.000 rs9900378 chr17:33911302 C/T cg19694781 chr19:47549865 TMEM160 0.44 7.01 0.36 1.36e-11 Response to radiotherapy in cancer (late toxicity); CRC cis rs863345 0.526 rs2051666 chr1:158507160 T/G cg12129480 chr1:158549410 OR10X1 -0.3 -6.17 -0.32 2.03e-9 Pneumococcal bacteremia; CRC cis rs7772486 0.622 rs1292333 chr6:145982344 C/T cg13319975 chr6:146136371 FBXO30 0.44 6.6 0.34 1.63e-10 Lobe attachment (rater-scored or self-reported); CRC cis rs798554 0.836 rs2260230 chr7:2822986 T/A cg14895029 chr7:2775587 GNA12 -0.45 -6.64 -0.34 1.3e-10 Height; CRC cis rs10504229 0.906 rs73607869 chr8:58172665 G/T cg02725872 chr8:58115012 NA -0.38 -6.43 -0.33 4.44e-10 Developmental language disorder (linguistic errors); CRC cis rs614226 1.000 rs616157 chr12:120925795 T/C cg27489772 chr12:121021490 NA -0.5 -6.56 -0.34 2.13e-10 Type 1 diabetes nephropathy; CRC cis rs916888 0.610 rs199536 chr17:44820425 T/C cg15921436 chr17:44337874 NA -0.52 -6.89 -0.36 2.81e-11 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs1448094 0.512 rs6539925 chr12:86244358 A/G cg02569458 chr12:86230093 RASSF9 0.42 7.24 0.37 3.17e-12 Major depressive disorder; CRC cis rs12928939 0.815 rs8049163 chr16:71719353 C/T cg08717414 chr16:71523259 ZNF19 -0.45 -5.61 -0.3 4.36e-8 Post bronchodilator FEV1; CRC cis rs6570726 0.791 rs12208019 chr6:145935572 T/C cg23711669 chr6:146136114 FBXO30 0.75 12.89 0.58 4.55e-31 Lobe attachment (rater-scored or self-reported); CRC trans rs2014572 1.000 rs3746231 chr19:57760057 G/A cg02674126 chr19:40336878 FBL 0.42 6.64 0.34 1.3e-10 Hyperactive-impulsive symptoms; CRC cis rs40363 0.645 rs250627 chr16:3527050 G/A cg21433313 chr16:3507492 NAT15 0.56 8.23 0.41 4.35e-15 Tuberculosis; CRC cis rs4282054 0.631 rs13081155 chr3:52732429 A/G cg05573699 chr3:52720067 GNL3;PBRM1 -0.53 -8.18 -0.41 6.34e-15 Cognitive function; CRC trans rs6951245 0.872 rs112309216 chr7:1100296 A/T cg13565492 chr6:43139072 SRF -0.72 -7.44 -0.38 8.63e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs4481887 0.861 rs6681336 chr1:248482756 C/T cg13385794 chr1:248469461 NA 0.4 7.11 0.36 7.23e-12 Common traits (Other); CRC cis rs10256972 0.567 rs7782651 chr7:1159895 T/G cg04025307 chr7:1156635 C7orf50 0.74 11.87 0.55 2.78e-27 Longevity;Endometriosis; CRC cis rs7662987 0.517 rs2602883 chr4:100040914 A/T cg12011299 chr4:100065546 ADH4 0.5 9.49 0.46 4.77e-19 Smoking initiation; CRC cis rs7914558 1.000 rs12780843 chr10:104769335 G/C cg04362960 chr10:104952993 NT5C2 0.6 9.04 0.45 1.33e-17 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs2370759 1.000 rs11597888 chr10:32635834 G/A cg01819863 chr10:32635814 EPC1 1.14 13.38 0.59 6.6e-33 Sexual dysfunction (female); CRC cis rs1707322 0.752 rs11211152 chr1:46114157 C/T cg03146154 chr1:46216737 IPP 0.66 9.64 0.47 1.6e-19 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg15097876 chr10:71993604 PPA1 0.46 6.39 0.33 5.83e-10 Response to antipsychotic treatment; CRC trans rs8035957 1.000 rs4924273 chr15:38846738 C/G cg10661591 chr3:100428033 TFG -0.52 -6.04 -0.32 4.21e-9 Type 1 diabetes; CRC cis rs2243480 1.000 rs58669269 chr7:65951953 T/C cg12463550 chr7:65579703 CRCP 0.65 5.72 0.3 2.4e-8 Diabetic kidney disease; CRC cis rs12024301 0.557 rs79818376 chr1:183598452 T/C cg11505048 chr1:183622726 RGL1;APOBEC4 0.76 6.93 0.36 2.16e-11 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs412050 0.502 rs17759796 chr22:22190163 A/C cg17089214 chr22:22089827 YPEL1 -0.57 -6.02 -0.32 4.54e-9 Attention deficit hyperactivity disorder; CRC cis rs6942756 0.747 rs692697 chr7:129112576 C/T cg02491457 chr7:128862824 NA 0.57 7.8 0.4 8.24e-14 White matter hyperintensity burden; CRC cis rs7786808 0.707 rs62479983 chr7:158227613 G/A cg15440763 chr7:158190612 PTPRN2 0.41 6.42 0.33 4.74e-10 Obesity-related traits; CRC cis rs7584330 0.554 rs10183995 chr2:238433307 G/A cg14458575 chr2:238380390 NA 0.53 7.01 0.36 1.36e-11 Prostate cancer; CRC trans rs57221529 0.766 rs4245972 chr5:578572 A/G cg11887960 chr12:57824829 NA 0.62 6.76 0.35 6.26e-11 Lung disease severity in cystic fibrosis; CRC cis rs7949030 0.626 rs7124057 chr11:62334096 A/G cg13298116 chr11:62369859 EML3;MTA2 0.61 10.89 0.51 8.54e-24 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; CRC cis rs1018836 0.923 rs4734269 chr8:91635474 G/C cg16814680 chr8:91681699 NA -0.74 -11.38 -0.53 1.65e-25 Ejection fraction in Tripanosoma cruzi seropositivity; CRC cis rs992157 0.710 rs6752254 chr2:219058743 C/T cg00012203 chr2:219082015 ARPC2 0.59 9.73 0.47 8.1e-20 Colorectal cancer; CRC cis rs9814567 0.762 rs13075332 chr3:134329836 C/G cg06109529 chr3:134205091 CEP63;ANAPC13 0.69 8.48 0.42 7.74e-16 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs889312 0.500 rs832552 chr5:56113850 A/C cg03609598 chr5:56110824 MAP3K1 0.44 6.32 0.33 8.59e-10 Breast cancer;Breast cancer (early onset); CRC cis rs6908034 0.607 rs113592672 chr6:19806063 G/C cg02682789 chr6:19804855 NA 0.79 6.75 0.35 6.62e-11 Endometriosis;Deep ovarian and/or rectovaginal disease with dense adhesions; CRC cis rs67478160 0.595 rs67768834 chr14:104221085 C/G cg08213375 chr14:104286397 PPP1R13B 0.65 13.76 0.6 2.47e-34 Schizophrenia; CRC cis rs801193 1.000 rs62466793 chr7:66191517 G/A cg00343986 chr7:65444356 GUSB 0.49 7.15 0.37 5.6e-12 Aortic root size; CRC cis rs394563 0.591 rs11964335 chr6:149658101 A/T cg03678062 chr6:149772716 ZC3H12D 0.33 6.02 0.31 4.7e-9 Dupuytren's disease; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg03610000 chr11:128392383 ETS1 -0.41 -6.32 -0.33 8.56e-10 Myopia (pathological); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg22479481 chr17:16120428 PIGL 0.47 6.73 0.35 7.54e-11 Response to antipsychotic treatment; CRC trans rs2228479 0.850 rs11645240 chr16:89837326 T/C cg24644049 chr4:85504048 CDS1 0.9 7.57 0.39 3.72e-13 Skin colour saturation; CRC cis rs7945705 0.935 rs2568062 chr11:8887945 A/G cg12365402 chr11:9010492 NRIP3 -0.49 -8.33 -0.42 2.25e-15 Hemoglobin concentration; CRC cis rs9443645 0.901 rs6912683 chr6:79543492 C/A cg11833968 chr6:79620685 NA -0.36 -6.25 -0.33 1.28e-9 Intelligence (multi-trait analysis); CRC cis rs2075371 0.829 rs35897242 chr7:134004041 G/A cg02659138 chr7:134003124 SLC35B4 0.42 7.34 0.38 1.65e-12 Mean platelet volume; CRC cis rs4972806 0.776 rs2072589 chr2:177042871 C/T cg09355771 chr2:177043147 NA 0.66 10.09 0.49 5.07e-21 IgG glycosylation; CRC cis rs7705042 0.865 rs6580229 chr5:141510754 A/G cg08523384 chr5:141488047 NDFIP1 -0.33 -5.82 -0.31 1.43e-8 Asthma; CRC cis rs12220238 1.000 rs10824075 chr10:75880254 T/C cg19889307 chr10:75911429 ADK;AP3M1 0.6 5.95 0.31 6.94e-9 Soluble interleukin-2 receptor subunit alpha; CRC cis rs1881797 1.000 rs67977965 chr1:247687835 G/A cg18198730 chr1:247681584 NA 0.54 8.41 0.42 1.25e-15 Acute lymphoblastic leukemia (childhood); CRC cis rs4638749 0.677 rs10203004 chr2:108826535 G/T cg25838818 chr2:108905173 SULT1C2 -0.34 -5.71 -0.3 2.52e-8 Blood pressure; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg00536289 chr16:28834130 ATXN2L 0.51 7.12 0.37 6.62e-12 Anxiety disorder; CRC cis rs889312 0.500 rs702691 chr5:56114526 T/G cg12311346 chr5:56204834 C5orf35 -0.46 -7.06 -0.36 9.71e-12 Breast cancer;Breast cancer (early onset); CRC cis rs7833790 0.700 rs28390260 chr8:82769175 A/T cg27398817 chr8:82754497 SNX16 0.43 5.95 0.31 6.84e-9 Diastolic blood pressure; CRC cis rs8072100 0.840 rs11079774 chr17:45479706 C/G cg25173405 chr17:45401733 C17orf57 -0.5 -8.01 -0.4 1.97e-14 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs3812049 0.826 rs34576922 chr5:127364103 C/G cg25462716 chr5:127418816 SLC12A2;FLJ33630 -0.78 -9.4 -0.46 9.27e-19 Lymphocyte counts;Red cell distribution width; CRC trans rs6956675 0.915 rs4717497 chr7:62645096 A/G cg01314568 chr7:57830625 NA -0.65 -9.29 -0.46 2.25e-18 Obesity-related traits; CRC cis rs4664293 0.625 rs7590617 chr2:160631948 A/G cg08347373 chr2:160653686 CD302 0.43 7.42 0.38 1.03e-12 Monocyte percentage of white cells; CRC cis rs4665809 0.590 rs6730310 chr2:26419470 C/G cg04944784 chr2:26401820 FAM59B -0.83 -10.56 -0.5 1.26e-22 Gut microbiome composition (summer); CRC cis rs4862750 0.872 rs7658314 chr4:187900356 T/C cg11301795 chr4:187892539 NA -0.87 -20.32 -0.75 4.87e-60 Lobe attachment (rater-scored or self-reported); CRC cis rs117623576 0.941 rs111379000 chr10:32427247 A/G cg03047570 chr10:32398778 NA -0.69 -7.39 -0.38 1.19e-12 Anti-saccade response; CRC cis rs2742417 0.935 rs2742393 chr3:45757417 T/A cg04837898 chr3:45731254 SACM1L -0.37 -6.03 -0.32 4.39e-9 Response to anti-depressant treatment in major depressive disorder; CRC cis rs7671266 0.559 rs7681212 chr4:10358964 C/G cg11266682 chr4:10021025 SLC2A9 0.42 6.53 0.34 2.5e-10 Cardiovascular disease risk factors; CRC cis rs12451471 0.529 rs2278620 chr17:78083565 G/A cg08347473 chr17:78092826 GAA -0.37 -6.13 -0.32 2.53e-9 Plateletcrit;Mean corpuscular hemoglobin concentration; CRC trans rs7819412 0.540 rs2409725 chr8:11041661 T/C cg06636001 chr8:8085503 FLJ10661 -0.45 -6.43 -0.33 4.46e-10 Triglycerides; CRC cis rs4716602 0.596 rs12386632 chr7:156158221 G/A cg16983916 chr7:156159713 NA -0.39 -6.92 -0.36 2.42e-11 Anti-saccade response; CRC cis rs2949837 0.581 rs1852210 chr7:45994256 C/T cg15898840 chr7:45960834 IGFBP3 0.46 7.49 0.38 6.55e-13 Sitting height ratio; CRC cis rs2228479 0.850 rs17232910 chr16:89839766 G/C cg06656553 chr16:89960601 TCF25 -0.7 -5.97 -0.31 6.14e-9 Skin colour saturation; CRC cis rs561341 1.000 rs498391 chr17:30328704 G/A cg12193833 chr17:30244370 NA -0.75 -8.83 -0.44 6.23e-17 Hip circumference adjusted for BMI; CRC cis rs12908161 0.683 rs12903256 chr15:85308141 G/T cg11189052 chr15:85197271 WDR73 0.5 7.45 0.38 8.21e-13 Schizophrenia; CRC cis rs9435341 0.965 rs2335077 chr1:107573565 A/G cg14671364 chr1:107599128 PRMT6 0.51 7.18 0.37 4.59e-12 Facial morphology (factor 21, depth of nasal alae); CRC cis rs17213078 0.505 rs737101 chr2:106732545 C/T cg15412446 chr2:106886593 NA 0.37 5.91 0.31 8.34e-9 Facial morphology (factor 23); CRC cis rs6502050 0.805 rs9915071 chr17:80119138 T/C cg22110888 chr17:80059540 CCDC57 0.4 6.38 0.33 5.96e-10 Life satisfaction; CRC cis rs7626444 0.625 rs1798637 chr3:196476639 C/T cg12930392 chr3:196481615 PAK2 0.4 7.26 0.37 2.73e-12 Monocyte count; CRC cis rs13144136 0.687 rs13128842 chr4:10661991 T/A cg10242279 chr4:10666415 CLNK -0.38 -6.66 -0.34 1.18e-10 Resistance to antihypertensive treatment in hypertension; CRC trans rs12699921 0.598 rs2691607 chr7:17879103 G/A cg15753394 chr6:17282781 RBM24 -0.36 -6.18 -0.32 1.86e-9 Fibrinogen levels; CRC cis rs597539 0.652 rs557625 chr11:68634722 G/A cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.89 15.85 0.66 1.89e-42 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs6429082 0.967 rs1305557 chr1:235627837 C/T cg26050004 chr1:235667680 B3GALNT2 0.46 6.77 0.35 5.91e-11 Adiposity; CRC cis rs12908161 0.515 rs12907646 chr15:85403496 G/A cg17507749 chr15:85114479 UBE2QP1 0.52 6.64 0.34 1.3e-10 Schizophrenia; CRC cis rs4713118 0.955 rs9393848 chr6:27688369 C/T cg20933634 chr6:27740509 NA 0.57 8.06 0.41 1.38e-14 Parkinson's disease; CRC cis rs12540874 0.542 rs4947581 chr7:50565967 G/A cg14593290 chr7:50529359 DDC -0.5 -7.16 -0.37 5.45e-12 Systemic sclerosis; CRC trans rs1814175 0.645 rs7119101 chr11:49955665 G/A cg15704280 chr7:45808275 SEPT13 -0.94 -16.88 -0.68 1.75e-46 Height; CRC cis rs8072100 0.811 rs1912483 chr17:45443494 A/G cg25173405 chr17:45401733 C17orf57 -0.52 -8.54 -0.43 5.04e-16 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC trans rs10411161 0.702 rs11879319 chr19:52389592 C/T cg22319618 chr22:45562946 NUP50 -0.61 -6.88 -0.35 2.96e-11 Breast cancer; CRC cis rs7191439 0.674 rs4782430 chr16:88792047 A/G cg27087555 chr16:88793112 FAM38A -1.39 -15.26 -0.64 4.07e-40 Plateletcrit; CRC cis rs4363385 0.669 rs4845519 chr1:153003916 G/T cg25856811 chr1:152973957 SPRR3 0.25 6.75 0.35 6.63e-11 Inflammatory skin disease; CRC cis rs11650494 0.908 rs8076023 chr17:47399633 C/G cg08112188 chr17:47440006 ZNF652 1.17 10.97 0.52 4.57e-24 Prostate cancer; CRC cis rs17253792 0.749 rs74979160 chr14:56097568 G/A cg24579896 chr14:56047964 C14orf33;KTN1 0.71 5.69 0.3 2.81e-8 Putamen volume; CRC cis rs881375 0.933 rs4837799 chr9:123668326 T/C cg14255062 chr9:123606675 PSMD5;LOC253039 0.43 6.16 0.32 2.07e-9 Rheumatoid arthritis; CRC cis rs977987 0.866 rs12932606 chr16:75493944 C/T cg03315344 chr16:75512273 CHST6 0.6 10.23 0.49 1.66e-21 Dupuytren's disease; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg02361612 chr7:130353136 COPG2 0.44 6.38 0.33 6.06e-10 Intelligence (multi-trait analysis); CRC cis rs6577655 0.517 rs4909293 chr8:135587888 G/A cg17885191 chr8:135476712 NA 0.5 5.62 0.3 4.09e-8 Visceral adipose tissue/subcutaneous adipose tissue ratio; CRC cis rs6952808 1.000 rs6954673 chr7:1886937 C/T cg22963979 chr7:1858916 MAD1L1 -0.66 -10.09 -0.49 4.87e-21 Bipolar disorder and schizophrenia; CRC cis rs6502050 0.723 rs8077209 chr17:80163221 A/G cg19223190 chr17:80058835 NA 0.39 6.26 0.33 1.2e-9 Life satisfaction; CRC cis rs763014 0.966 rs4247097 chr16:654224 G/A cg00802000 chr16:706648 WDR90 -0.44 -6.45 -0.33 4.05e-10 Height; CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg08577743 chr9:38621011 C9orf122;ANKRD18A -0.53 -6.86 -0.35 3.39e-11 Diisocyanate-induced asthma; CRC cis rs4076764 0.914 rs6689760 chr1:163358704 A/G cg24596788 chr1:163392923 NA 0.64 10.13 0.49 3.48e-21 Motion sickness; CRC cis rs9903692 0.954 rs6847 chr17:46147807 A/T cg10706073 chr17:46328419 SKAP1 0.42 5.65 0.3 3.55e-8 Pulse pressure; CRC cis rs3617 0.573 rs9825230 chr3:52901974 G/A cg15147215 chr3:52552868 STAB1 -0.43 -6.84 -0.35 3.91e-11 Red blood cell count;Autism spectrum disorder or schizophrenia; CRC cis rs909341 0.710 rs6011016 chr20:62302650 C/G cg16989086 chr20:62203971 PRIC285 -0.49 -6.39 -0.33 5.79e-10 Atopic dermatitis; CRC cis rs12802200 0.561 rs7940600 chr11:572105 A/G cg01842473 chr11:617407 IRF7;MUPCDH -0.49 -6.39 -0.33 5.54e-10 Systemic lupus erythematosus; CRC cis rs9393692 0.557 rs9366648 chr6:26306282 T/C cg13736514 chr6:26305472 NA -0.45 -7.3 -0.37 2.21e-12 Educational attainment; CRC trans rs7944735 0.517 rs7952205 chr11:48199227 A/G cg15704280 chr7:45808275 SEPT13 0.61 6.27 0.33 1.14e-9 Intraocular pressure; CRC cis rs1816752 0.935 rs4770676 chr13:25003883 A/G cg02811702 chr13:24901961 NA 0.47 6.47 0.34 3.62e-10 Obesity-related traits; CRC trans rs9693857 0.520 rs7821875 chr8:9359312 G/T cg06636001 chr8:8085503 FLJ10661 0.46 6.24 0.33 1.38e-9 Systolic blood pressure; CRC cis rs7224685 0.501 rs4790168 chr17:4022457 T/C cg09597638 chr17:3907349 NA -0.65 -11.3 -0.53 3.03e-25 Type 2 diabetes; CRC trans rs7618501 0.722 rs9853458 chr3:49783211 A/C cg21659725 chr3:3221576 CRBN -0.9 -17.3 -0.69 3.95e-48 Intelligence (multi-trait analysis); CRC cis rs9807989 0.765 rs6704565 chr2:102967431 G/A cg03938978 chr2:103052716 IL18RAP 0.37 5.97 0.31 6.2e-9 Asthma; CRC trans rs800082 1.000 rs2717391 chr3:144279698 T/C cg24215973 chr2:240111563 HDAC4 0.52 6.94 0.36 2.11e-11 Smoking behavior; CRC cis rs2228479 0.850 rs11647174 chr16:89958538 G/A cg06558623 chr16:89946397 TCF25 1.08 10.68 0.51 4.63e-23 Skin colour saturation; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg20149956 chr1:249132233 ZNF672 0.39 6.17 0.32 2.02e-9 Liver disease severity in Alagille syndrome; CRC cis rs6502050 0.835 rs34960918 chr17:80113925 A/G cg22110888 chr17:80059540 CCDC57 0.4 6.44 0.33 4.17e-10 Life satisfaction; CRC cis rs8067545 0.611 rs2703812 chr17:20114803 A/G cg13482628 chr17:19912719 NA -0.46 -7.29 -0.37 2.38e-12 Schizophrenia; CRC cis rs9322193 0.923 rs9688452 chr6:149979900 G/A cg00933542 chr6:150070202 PCMT1 0.31 6.44 0.33 4.28e-10 Lung cancer; CRC cis rs1355223 0.583 rs2956076 chr11:34874124 T/C cg24088639 chr11:34937564 PDHX;APIP -0.58 -8.52 -0.43 5.82e-16 Systemic lupus erythematosus and Systemic sclerosis; CRC cis rs3096299 0.685 rs12935112 chr16:89542858 C/T cg00750074 chr16:89608354 SPG7 0.45 6.91 0.36 2.56e-11 Multiple myeloma (IgH translocation); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg02114786 chr21:46293672 PTTG1IP 0.45 6.26 0.33 1.18e-9 Response to antipsychotic treatment; CRC cis rs79349575 0.715 rs11657238 chr17:46985634 A/G cg22482690 chr17:47019901 SNF8 0.43 7.05 0.36 1.09e-11 Type 2 diabetes; CRC cis rs514406 0.861 rs7518390 chr1:53233374 A/G cg24675658 chr1:53192096 ZYG11B 0.53 7.73 0.39 1.34e-13 Monocyte count; CRC cis rs9443645 0.588 rs1415310 chr6:79822314 C/T cg09184832 chr6:79620586 NA -0.39 -6.68 -0.35 1.05e-10 Intelligence (multi-trait analysis); CRC cis rs9322193 0.923 rs9800686 chr6:149955600 A/C cg05861140 chr6:150128134 PCMT1 -0.37 -5.78 -0.3 1.72e-8 Lung cancer; CRC trans rs61931739 0.534 rs2220547 chr12:34106255 G/A cg26384229 chr12:38710491 ALG10B 0.54 6.95 0.36 2e-11 Morning vs. evening chronotype; CRC cis rs10256972 0.591 rs10229680 chr7:1158565 C/T cg23978390 chr7:1156363 C7orf50 0.6 8.3 0.42 2.66e-15 Longevity;Endometriosis; CRC cis rs12760731 0.720 rs722321 chr1:178420220 C/T cg00404053 chr1:178313656 RASAL2 1.08 11.28 0.53 3.58e-25 Obesity-related traits; CRC cis rs6445525 0.935 rs4688632 chr3:66000290 A/G cg06109867 chr3:66002991 MAGI1 -0.4 -6.79 -0.35 5.4e-11 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs939584 1.000 rs4854348 chr2:647760 A/G cg03610516 chr2:642275 NA 0.41 5.93 0.31 7.83e-9 Body mass index; CRC cis rs12142240 0.731 rs6681857 chr1:46850124 T/C cg14993813 chr1:46806288 NSUN4 -0.48 -6.07 -0.32 3.6e-9 Menopause (age at onset); CRC cis rs28386778 0.897 rs6504177 chr17:61812655 C/T cg23090583 chr17:61904693 PSMC5;FTSJ3 0.98 18.6 0.72 2.81e-53 Prudent dietary pattern; CRC trans rs10838798 0.504 rs11039673 chr11:48335156 G/A cg15704280 chr7:45808275 SEPT13 -0.48 -6.73 -0.35 7.6e-11 Height; CRC cis rs60871478 0.679 rs4076965 chr7:793272 A/G cg13844804 chr7:814759 HEATR2 0.68 7.43 0.38 9.18e-13 Cerebrospinal P-tau181p levels; CRC cis rs2949837 0.581 rs2965068 chr7:45974375 T/C cg15898840 chr7:45960834 IGFBP3 0.43 7.2 0.37 4.24e-12 Sitting height ratio; CRC cis rs4423214 0.840 rs1792315 chr11:71165547 C/T cg13043300 chr11:71146211 DHCR7 -0.44 -5.84 -0.31 1.28e-8 Vitamin D levels; CRC cis rs2075371 0.966 rs2544224 chr7:133995832 A/G cg11752832 chr7:134001865 SLC35B4 0.5 7.72 0.39 1.45e-13 Mean platelet volume; CRC cis rs9916302 0.904 rs801419 chr17:37466327 A/G cg07936489 chr17:37558343 FBXL20 0.8 11.82 0.55 4.1e-27 Glomerular filtration rate (creatinine); CRC cis rs3806843 0.900 rs2531340 chr5:140131046 C/T cg19875535 chr5:140030758 IK -0.53 -8.41 -0.42 1.22e-15 Depressive symptoms (multi-trait analysis); CRC trans rs7618501 0.602 rs2245365 chr3:50097319 C/A cg21665057 chr3:196295764 WDR53;FBXO45 -0.61 -9.68 -0.47 1.13e-19 Intelligence (multi-trait analysis); CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg08877624 chr8:141521446 CHRAC1 0.38 6.36 0.33 6.88e-10 Obesity-related traits; CRC cis rs17376456 1.000 rs13181660 chr5:93533658 A/G cg21475434 chr5:93447410 FAM172A 0.68 6.85 0.35 3.55e-11 Diabetic retinopathy; CRC cis rs9322193 0.923 rs9689599 chr6:149953109 A/C cg00933542 chr6:150070202 PCMT1 0.29 6.08 0.32 3.37e-9 Lung cancer; CRC cis rs11764590 0.694 rs4721359 chr7:2104951 A/G cg14004847 chr7:1930337 MAD1L1 -0.43 -5.74 -0.3 2.21e-8 Neuroticism; CRC cis rs2032447 0.869 rs199752 chr6:26012875 C/T cg17691542 chr6:26056736 HIST1H1C 0.42 5.76 0.3 1.96e-8 Intelligence (multi-trait analysis); CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg24707616 chr17:16342815 NCRNA00188;SNORD49B;SNORD49A 0.51 6.68 0.35 1.02e-10 Thyroid stimulating hormone; CRC cis rs8114671 0.562 rs6088635 chr20:33466501 A/G cg07148914 chr20:33460835 GGT7 0.43 7.05 0.36 1.08e-11 Height; CRC cis rs9393692 0.557 rs725575 chr6:26301919 A/T cg13736514 chr6:26305472 NA -0.45 -7.34 -0.38 1.67e-12 Educational attainment; CRC cis rs11249608 0.548 rs6894076 chr5:178449813 T/C cg01312482 chr5:178451176 ZNF879 -0.36 -5.98 -0.31 5.94e-9 Pubertal anthropometrics; CRC cis rs2832191 0.632 rs2246777 chr21:30309586 T/C cg08807101 chr21:30365312 RNF160 -0.7 -10.75 -0.51 2.57e-23 Dental caries; CRC cis rs7666738 0.715 rs3857216 chr4:99032129 G/T cg05340658 chr4:99064831 C4orf37 0.61 9.42 0.46 8.23e-19 Colonoscopy-negative controls vs population controls; CRC trans rs853679 0.825 rs8180562 chr6:28141460 G/A cg06606381 chr12:133084897 FBRSL1 -0.92 -7.54 -0.38 4.53e-13 Depression; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg14929913 chr10:1147979 WDR37 -0.41 -6.59 -0.34 1.71e-10 Liver disease severity in Alagille syndrome; CRC cis rs7772486 0.875 rs9322048 chr6:146400439 A/G cg13319975 chr6:146136371 FBXO30 -0.37 -5.76 -0.3 1.92e-8 Lobe attachment (rater-scored or self-reported); CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg08830818 chr3:122514143 HSPBAP1;DIRC2 0.34 6.18 0.32 1.95e-9 Obesity-related traits; CRC cis rs10065203 0.527 rs152177 chr5:14354270 G/A cg26689441 chr5:14406021 TRIO -0.37 -6.19 -0.32 1.78e-9 Paclitaxel-induced neuropathy; CRC cis rs6701037 0.566 rs4344281 chr1:175135376 C/T cg17845761 chr1:175162550 KIAA0040 0.3 6.23 0.32 1.47e-9 Alcohol dependence; CRC cis rs172166 0.516 rs1225710 chr6:28100640 C/T cg12273811 chr6:28175739 NA -0.45 -6.75 -0.35 6.7e-11 Cardiac Troponin-T levels; CRC cis rs6951245 1.000 rs113858334 chr7:1073476 A/G cg20603222 chr7:1096387 C7orf50;GPR146 -0.69 -8.1 -0.41 1.07e-14 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs7659604 1.000 rs73844281 chr4:122664688 A/G cg06713675 chr4:122721982 EXOSC9 -0.38 -6.26 -0.33 1.17e-9 Type 2 diabetes; CRC cis rs9322193 0.923 rs9478291 chr6:150050570 A/G cg13206674 chr6:150067644 NUP43 0.69 10.43 0.5 3.29e-22 Lung cancer; CRC cis rs6921919 0.697 rs758398 chr6:28320674 C/T cg03623178 chr6:28175578 NA 0.45 6.04 0.32 4.23e-9 Autism spectrum disorder or schizophrenia; CRC cis rs9372498 0.536 rs9489447 chr6:118900846 G/A cg07617317 chr6:118971624 C6orf204 0.49 6.15 0.32 2.23e-9 Diastolic blood pressure; CRC cis rs60871478 1.000 rs62432251 chr7:801855 T/G cg05535760 chr7:792225 HEATR2 0.79 10.07 0.49 5.93e-21 Cerebrospinal P-tau181p levels; CRC cis rs995000 0.931 rs11207983 chr1:63012107 C/T cg19896129 chr1:63156450 NA -0.44 -6.92 -0.36 2.4e-11 Triglyceride levels; CRC cis rs4363385 0.720 rs1611755 chr1:152956420 T/C cg25856811 chr1:152973957 SPRR3 -0.26 -7.35 -0.38 1.63e-12 Inflammatory skin disease; CRC cis rs8180040 1.000 rs8180040 chr3:47388947 A/T cg02527881 chr3:46936655 PTH1R -0.38 -6.89 -0.36 2.77e-11 Colorectal cancer; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg09133386 chr6:20404188 E2F3 0.48 6.17 0.32 2.02e-9 Thyroid stimulating hormone; CRC cis rs2019137 0.936 rs2305133 chr2:113956821 C/G cg19083407 chr2:113993142 PAX8;LOC440839;LOC654433 -0.46 -6.45 -0.34 4e-10 Lymphocyte counts; CRC cis rs12545109 0.837 rs1437277 chr8:57356734 T/C cg09654669 chr8:57350985 NA -0.44 -5.93 -0.31 7.85e-9 Obesity-related traits; CRC cis rs875971 0.862 rs10950043 chr7:65988610 T/C cg00343986 chr7:65444356 GUSB 0.44 6.15 0.32 2.21e-9 Aortic root size; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg05226292 chr8:71520850 TRAM1 0.38 6.0 0.31 5.34e-9 Liver disease severity in Alagille syndrome; CRC cis rs600806 0.821 rs3879447 chr1:109891403 C/T cg23032129 chr1:109941072 SORT1 -0.27 -5.79 -0.3 1.65e-8 Intelligence (multi-trait analysis); CRC cis rs7474896 0.515 rs2738208 chr10:38306128 A/G cg25427524 chr10:38739819 LOC399744 0.6 7.34 0.37 1.73e-12 Obesity (extreme); CRC cis rs950169 1.000 rs12903820 chr15:84723820 A/G cg17507749 chr15:85114479 UBE2QP1 0.78 12.03 0.55 6.93e-28 Schizophrenia; CRC cis rs4363385 0.747 rs4845506 chr1:152968407 G/A cg25856811 chr1:152973957 SPRR3 -0.25 -6.99 -0.36 1.58e-11 Inflammatory skin disease; CRC cis rs853679 0.546 rs200981 chr6:27833174 A/G cg03623178 chr6:28175578 NA 0.78 6.87 0.35 3.3e-11 Depression; CRC cis rs916888 0.647 rs199449 chr17:44808902 G/A cg01570182 chr17:44337453 NA 0.74 9.46 0.46 5.88e-19 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs1552244 0.882 rs6796419 chr3:10040812 G/A cg00166722 chr3:10149974 C3orf24 0.57 7.8 0.4 8.13e-14 Alzheimer's disease; CRC cis rs6762 0.748 rs1130663 chr11:837582 G/A cg07691484 chr11:842764 TSPAN4;POLR2L -0.56 -8.33 -0.42 2.23e-15 Mean platelet volume; CRC cis rs6540559 0.673 rs6694552 chr1:209976459 A/C cg23283495 chr1:209979779 IRF6 0.48 6.85 0.35 3.68e-11 Cleft lip with or without cleft palate; CRC cis rs9611565 0.592 rs4822044 chr22:41979668 G/C cg06634786 chr22:41940651 POLR3H -0.64 -6.71 -0.35 8.33e-11 Vitiligo; CRC cis rs422249 0.512 rs174568 chr11:61593816 C/T cg06781209 chr11:61594997 FADS2 -0.38 -5.61 -0.3 4.33e-8 Trans fatty acid levels; CRC cis rs3736594 0.513 rs62131881 chr2:27764781 G/T cg27432699 chr2:27873401 GPN1 0.66 8.5 0.42 6.57e-16 Fasting blood glucose;Fasting blood glucose (BMI interaction); CRC trans rs7395662 0.571 rs12421145 chr11:48624725 C/A cg15704280 chr7:45808275 SEPT13 -0.49 -6.85 -0.35 3.64e-11 HDL cholesterol; CRC cis rs863345 0.504 rs857707 chr1:158564383 A/G cg12129480 chr1:158549410 OR10X1 -0.34 -7.16 -0.37 5.25e-12 Pneumococcal bacteremia; CRC cis rs10229583 0.563 rs7801118 chr7:127263886 G/A cg01233922 chr7:127693937 SND1 -0.44 -6.3 -0.33 9.77e-10 Type 2 diabetes; CRC cis rs7089973 0.872 rs7075888 chr10:116627117 C/T cg03647239 chr10:116582469 FAM160B1 0.41 5.79 0.3 1.67e-8 Bipolar disorder or attention deficit hyperactivity disorder; CRC cis rs2274273 0.686 rs2182207 chr14:55589803 G/A cg10130446 chr14:55658398 DLGAP5 -0.43 -5.8 -0.3 1.57e-8 Protein biomarker; CRC cis rs6684514 1.000 rs10908496 chr1:156264000 G/A cg16558208 chr1:156270281 VHLL 0.57 8.85 0.44 5.32e-17 Mean corpuscular hemoglobin concentration;Glycated hemoglobin levels; CRC cis rs703842 1.000 rs1875124 chr12:58196802 A/G cg00677455 chr12:58241039 CTDSP2 0.64 8.66 0.43 2.14e-16 Multiple sclerosis; CRC cis rs79387448 0.683 rs7571985 chr2:103147561 G/A cg09003973 chr2:102972529 NA 0.73 8.11 0.41 9.98e-15 Gut microbiota (bacterial taxa); CRC cis rs9788721 0.836 rs2656052 chr15:78740932 A/C cg18825076 chr15:78729989 IREB2 -0.46 -7.23 -0.37 3.33e-12 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio;Emphysema imaging phenotypes;Emphysema distribution in smoking;Local histogram emphysema pattern;Post bronchodilator FEV1/FVC ratio in COPD; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg03813033 chr19:50380022 AKT1S1;TBC1D17 0.44 6.34 0.33 7.64e-10 Response to antipsychotic treatment; CRC cis rs9911578 1.000 rs2643119 chr17:56827760 G/T cg05425664 chr17:57184151 TRIM37 -0.48 -7.6 -0.39 3.02e-13 Intelligence (multi-trait analysis); CRC cis rs1322512 1.000 rs1282551 chr6:153009944 C/T cg03415253 chr6:152958462 SYNE1 0.4 6.04 0.32 4.14e-9 Tonometry; CRC cis rs7945705 0.747 rs11042150 chr11:9010819 T/C cg00186954 chr11:8933980 ST5;C11orf17 -0.45 -7.66 -0.39 2.12e-13 Hemoglobin concentration; CRC cis rs4689388 0.926 rs4416547 chr4:6293967 G/A cg00701064 chr4:6280414 WFS1 0.75 13.24 0.59 2.22e-32 Type 2 diabetes and other traits;Type 2 diabetes; CRC cis rs6063312 0.518 rs6122718 chr20:47346225 A/G cg18078177 chr20:47281410 PREX1 -0.56 -8.64 -0.43 2.46e-16 Tonometry; CRC cis rs853679 0.550 rs1150689 chr6:28165099 T/C cg03623178 chr6:28175578 NA 1.0 15.19 0.64 7.35e-40 Depression; CRC cis rs7772486 0.875 rs9373485 chr6:146401429 A/T cg13319975 chr6:146136371 FBXO30 -0.41 -6.37 -0.33 6.52e-10 Lobe attachment (rater-scored or self-reported); CRC cis rs2077654 0.822 rs4148634 chr11:17429872 G/A cg25308976 chr11:17434268 ABCC8 0.81 7.97 0.4 2.55e-14 Gout; CRC cis rs4363385 0.782 rs1933381 chr1:153003255 C/G cg25856811 chr1:152973957 SPRR3 -0.25 -7.05 -0.36 1.07e-11 Inflammatory skin disease; CRC cis rs11122895 0.610 rs13397902 chr2:112607505 G/C cg23215929 chr2:112641879 ANAPC1 -0.41 -5.94 -0.31 7.16e-9 Allergic sensitization; CRC cis rs1561198 0.523 rs2118177 chr2:85890293 A/G cg02493740 chr2:85810744 VAMP5 -0.38 -5.78 -0.3 1.73e-8 Coronary artery disease; CRC cis rs514406 0.825 rs3863643 chr1:53224577 C/T cg24675658 chr1:53192096 ZYG11B 0.53 7.8 0.39 8.34e-14 Monocyte count; CRC cis rs2153535 0.601 rs7738877 chr6:8542230 A/G cg07606381 chr6:8435919 SLC35B3 0.64 10.42 0.5 3.84e-22 Motion sickness; CRC cis rs2839186 0.632 rs17176110 chr21:47706535 C/A cg09417038 chr21:47716443 C21orf57 -0.5 -8.38 -0.42 1.53e-15 Testicular germ cell tumor; CRC cis rs2180341 1.000 rs9401950 chr6:127655485 C/T cg27446573 chr6:127587934 RNF146 0.99 14.58 0.63 1.75e-37 Breast cancer; CRC cis rs57221529 0.766 rs4245972 chr5:578572 A/G cg09021430 chr5:549028 NA -0.72 -7.86 -0.4 5.63e-14 Lung disease severity in cystic fibrosis; CRC cis rs17376456 1.000 rs12188453 chr5:93560807 G/T cg09848695 chr5:92956644 FAM172A;MIR2277 -0.68 -5.91 -0.31 8.34e-9 Diabetic retinopathy; CRC cis rs6674176 0.628 rs2240447 chr1:44415415 C/T cg12908607 chr1:44402522 ARTN -0.58 -10.47 -0.5 2.47e-22 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Cognitive ability; CRC cis rs4076764 0.914 rs12123378 chr1:163377846 C/T cg06092702 chr1:163392909 NA -0.56 -8.84 -0.44 5.8e-17 Motion sickness; CRC trans rs8073060 0.572 rs1634683 chr17:33941560 G/C cg19694781 chr19:47549865 TMEM160 -0.98 -13.52 -0.6 1.98e-33 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; CRC cis rs701145 0.617 rs9820619 chr3:154028294 G/T cg16511985 chr3:153974050 SGEF 0.43 5.62 0.3 4e-8 Coronary artery disease; CRC cis rs2836974 0.897 rs12481860 chr21:40537836 T/A cg11890956 chr21:40555474 PSMG1 1.08 19.02 0.72 5.97e-55 Cognitive function; CRC cis rs372883 0.600 rs1312254 chr21:30695401 A/G cg24692254 chr21:30365293 RNF160 -0.64 -9.45 -0.46 6.43e-19 Pancreatic cancer; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg20401393 chr6:4135757 PECI 0.44 6.55 0.34 2.17e-10 Intelligence (multi-trait analysis); CRC cis rs1707322 1.000 rs7532204 chr1:46485075 C/G cg03146154 chr1:46216737 IPP -0.5 -6.97 -0.36 1.72e-11 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs172166 0.694 rs1225716 chr6:28113746 A/C cg25164649 chr6:28176230 NA 0.64 9.04 0.45 1.41e-17 Cardiac Troponin-T levels; CRC trans rs66759488 0.739 rs10851451 chr15:47608991 A/G cg08551088 chr10:121631655 C10orf119 -0.46 -6.07 -0.32 3.6e-9 Lung cancer; CRC cis rs17384381 0.953 rs12130145 chr1:85828970 G/C cg16011679 chr1:85725395 C1orf52 0.67 6.84 0.35 3.99e-11 Lobe attachment (rater-scored or self-reported); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg14723799 chr14:50101089 C14orf104 0.42 6.27 0.33 1.16e-9 Intelligence (multi-trait analysis); CRC cis rs75920871 0.528 rs7935834 chr11:116944437 C/G cg20608306 chr11:116969690 SIK3 -0.35 -6.74 -0.35 6.96e-11 Subjective well-being; CRC cis rs600231 0.623 rs587080 chr11:65253800 A/C cg17120908 chr11:65337727 SSSCA1 -0.6 -9.07 -0.45 1.08e-17 Bone mineral density; CRC cis rs751728 0.664 rs6929696 chr6:33759290 C/T cg25922239 chr6:33757077 LEMD2 -0.45 -6.74 -0.35 6.9e-11 Crohn's disease; CRC cis rs7412746 0.587 rs3849279 chr1:150944707 T/C cg17724175 chr1:150552817 MCL1 0.41 6.16 0.32 2.13e-9 Melanoma; CRC cis rs9322193 0.887 rs9767113 chr6:150039293 T/C cg05861140 chr6:150128134 PCMT1 -0.38 -5.85 -0.31 1.22e-8 Lung cancer; CRC cis rs920590 0.758 rs35280191 chr8:19665214 A/C cg03894339 chr8:19674705 INTS10 0.42 5.84 0.31 1.27e-8 Acute lymphoblastic leukemia (childhood); CRC trans rs7690467 0.794 rs62318144 chr4:133394581 C/T cg19296258 chr17:78878799 RPTOR -0.47 -6.23 -0.32 1.42e-9 Eating disorders; CRC cis rs1348850 0.634 rs1534304 chr2:178489264 C/T cg27490568 chr2:178487706 NA 0.51 7.25 0.37 2.95e-12 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs8103278 0.507 rs4802276 chr19:46260748 T/C cg11657440 chr19:46296263 DMWD 0.74 12.89 0.58 4.56e-31 Coronary artery disease; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg11808854 chr20:60697627 LSM14B 0.36 6.3 0.33 9.73e-10 Liver disease severity in Alagille syndrome; CRC cis rs9322193 0.923 rs9322214 chr6:150025122 C/T cg07701084 chr6:150067640 NUP43 0.57 8.02 0.4 1.92e-14 Lung cancer; CRC cis rs1707322 0.721 rs11211181 chr1:46236800 C/T cg06784218 chr1:46089804 CCDC17 0.54 9.91 0.48 2.03e-20 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC trans rs2303319 0.504 rs62189052 chr2:162623869 C/G cg22902534 chr3:183892754 AP2M1 -0.7 -6.07 -0.32 3.56e-9 Cognitive function; CRC cis rs10791323 0.517 rs1120246 chr11:133745212 G/A cg06766960 chr11:133703094 NA -0.32 -5.68 -0.3 2.89e-8 Childhood ear infection; CRC cis rs13392177 0.647 rs6718220 chr2:219066518 T/C cg04880052 chr2:219191631 PNKD -0.39 -5.9 -0.31 9.12e-9 Pyoderma gangrenosum in inflammatory bowel disease; CRC cis rs6761276 0.649 rs3827763 chr2:113831289 C/T cg09040174 chr2:113837401 NA -0.43 -5.78 -0.3 1.74e-8 Protein quantitative trait loci; CRC cis rs1862618 0.573 rs185220 chr5:56205357 A/G cg18230493 chr5:56204884 C5orf35 -0.89 -11.73 -0.54 8.92e-27 Initial pursuit acceleration; CRC cis rs910316 1.000 rs12897094 chr14:75579416 C/T cg03030879 chr14:75389066 RPS6KL1 -0.47 -7.36 -0.38 1.53e-12 Height; CRC cis rs3849570 0.643 rs6797240 chr3:81971856 T/C cg07356753 chr3:81810745 GBE1 -0.47 -6.42 -0.33 4.89e-10 Waist circumference;Body mass index; CRC cis rs17826219 0.568 rs7213925 chr17:29121634 A/G cg01831904 chr17:28903510 LRRC37B2 -0.63 -6.49 -0.34 3.2e-10 Body mass index; CRC cis rs4808199 0.948 rs7259434 chr19:19428805 A/T cg03709012 chr19:19516395 GATAD2A 0.88 11.02 0.52 3.07e-24 Nonalcoholic fatty liver disease; CRC trans rs561341 0.505 rs28708703 chr17:30386845 C/G cg20587970 chr11:113659929 NA -1.1 -15.9 -0.66 1.25e-42 Hip circumference adjusted for BMI; CRC cis rs2067615 0.599 rs12369214 chr12:107198611 G/A cg13491945 chr12:107078410 RFX4 0.35 6.0 0.31 5.12e-9 Heart rate; CRC cis rs1448094 0.511 rs2405616 chr12:86148042 A/G cg00310523 chr12:86230176 RASSF9 -0.36 -5.92 -0.31 8.25e-9 Major depressive disorder; CRC trans rs1814175 0.645 rs4411280 chr11:49962750 A/G cg11707556 chr5:10655725 ANKRD33B -0.52 -10.05 -0.48 6.61e-21 Height; CRC cis rs7618915 0.547 rs11130314 chr3:52697082 T/C cg11645453 chr3:52864694 ITIH4 0.35 6.14 0.32 2.31e-9 Bipolar disorder; CRC cis rs9733 0.596 rs11807058 chr1:150640475 G/A cg10589385 chr1:150898437 SETDB1 0.28 5.98 0.31 5.86e-9 Tonsillectomy; CRC cis rs524281 0.731 rs2276036 chr11:66033430 C/T cg14036092 chr11:66035641 RAB1B -0.55 -6.04 -0.32 4.16e-9 Electroencephalogram traits; CRC cis rs9346649 0.630 rs4708641 chr6:168491416 G/A cg02770688 chr6:168491649 NA 0.63 9.28 0.46 2.38e-18 Venous thromboembolism adjusted for sickle cell variant rs77121243-T; CRC cis rs12477438 0.798 rs10196680 chr2:99628617 A/G cg14399236 chr2:99771627 LIPT1;TSGA10 -0.74 -10.42 -0.5 3.73e-22 Chronic sinus infection; CRC cis rs9399135 0.967 rs1041480 chr6:135373076 G/T cg22676075 chr6:135203613 NA 0.39 6.08 0.32 3.42e-9 Red blood cell count; CRC cis rs10128264 0.609 rs1250591 chr10:80985374 A/G cg20744163 chr10:80999841 ZMIZ1 -0.34 -6.0 -0.31 5.23e-9 Response to methotrexate in juvenile idiopathic arthritis; CRC cis rs9916302 0.851 rs12947620 chr17:37605364 T/C cg07936489 chr17:37558343 FBXL20 -0.84 -13.1 -0.59 7.38e-32 Glomerular filtration rate (creatinine); CRC cis rs798554 0.836 rs2260230 chr7:2822986 T/A cg19717773 chr7:2847554 GNA12 -0.46 -6.53 -0.34 2.5e-10 Height; CRC cis rs4654899 0.833 rs10127757 chr1:21490045 A/G cg02927042 chr1:21476669 EIF4G3 -0.49 -7.66 -0.39 2.11e-13 Superior frontal gyrus grey matter volume; CRC cis rs6582630 0.519 rs12366667 chr12:38332632 C/T cg26384229 chr12:38710491 ALG10B 0.68 9.52 0.46 3.79e-19 Drug-induced liver injury (flucloxacillin); CRC trans rs7267979 0.903 rs2474769 chr20:25248725 C/T cg17903999 chr18:56338584 MALT1 -0.4 -6.38 -0.33 6.05e-10 Liver enzyme levels (alkaline phosphatase); CRC cis rs847577 0.515 rs10953238 chr7:97676259 C/T cg24562669 chr7:97807699 LMTK2 0.72 15.63 0.65 1.47e-41 Breast cancer; CRC cis rs12824058 0.831 rs12300308 chr12:130813825 G/A cg26677194 chr12:130822605 PIWIL1 0.45 7.22 0.37 3.62e-12 Menopause (age at onset); CRC cis rs919433 0.889 rs787998 chr2:198216092 A/G cg10820045 chr2:198174542 NA 0.48 8.41 0.42 1.24e-15 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC cis rs950169 0.960 rs35159785 chr15:84804014 G/A cg11189052 chr15:85197271 WDR73 0.63 8.87 0.44 4.87e-17 Schizophrenia; CRC cis rs10781543 0.839 rs6560632 chr9:139371786 A/C cg14169450 chr9:139327907 INPP5E 0.37 5.74 0.3 2.18e-8 Monocyte percentage of white cells; CRC cis rs2721195 0.874 rs2721173 chr8:145744429 C/T cg15320075 chr8:145703422 NA 0.55 9.04 0.45 1.34e-17 Age at first birth; CRC cis rs9322193 0.923 rs2342857 chr6:150130673 G/A cg05861140 chr6:150128134 PCMT1 -0.42 -6.83 -0.35 4.19e-11 Lung cancer; CRC cis rs1552244 0.872 rs6803517 chr3:10065426 C/T cg10729496 chr3:10149963 C3orf24 0.5 6.71 0.35 8.29e-11 Alzheimer's disease; CRC cis rs6504622 0.557 rs11654971 chr17:44998563 G/A cg16759221 chr17:45003025 GOSR2 0.6 9.66 0.47 1.33e-19 Orofacial clefts; CRC cis rs78456975 1.000 rs78456975 chr2:1554190 T/G cg12573674 chr2:1569213 NA -0.76 -7.84 -0.4 6.48e-14 Placebo response in major depressive disorder (% change in symptom score); CRC cis rs1451375 0.657 rs7802148 chr7:50648284 T/C cg14593290 chr7:50529359 DDC 0.51 7.11 0.37 7.09e-12 Malaria; CRC cis rs9287719 0.639 rs2357650 chr2:10696877 C/T cg00105475 chr2:10696890 NA 0.55 9.21 0.45 3.94e-18 Prostate cancer; CRC cis rs12497850 0.931 rs4974082 chr3:48999323 G/A cg20833759 chr3:49053208 WDR6;DALRD3 0.47 8.03 0.4 1.71e-14 Parkinson's disease; CRC cis rs28386778 0.897 rs57108948 chr17:61802378 T/C cg11494091 chr17:61959527 GH2 0.61 10.2 0.49 2.05e-21 Prudent dietary pattern; CRC trans rs11098499 0.739 rs2203039 chr4:120132347 T/C cg25214090 chr10:38739885 LOC399744 -0.42 -6.73 -0.35 7.57e-11 Corneal astigmatism; CRC cis rs763121 0.853 rs3827357 chr22:39079413 A/G cg06544989 chr22:39130855 UNC84B 0.45 6.92 0.36 2.35e-11 Menopause (age at onset); CRC cis rs796364 0.806 rs112305133 chr2:201010380 A/G cg25936922 chr2:200820526 C2orf60;C2orf47 -0.57 -5.67 -0.3 3.07e-8 Schizophrenia; CRC cis rs4665809 0.627 rs1465720 chr2:26412638 G/T cg25036284 chr2:26402008 FAM59B -0.63 -8.03 -0.4 1.73e-14 Gut microbiome composition (summer); CRC cis rs5750830 0.595 rs4821892 chr22:39795683 G/C cg05872129 chr22:39784769 NA -0.59 -10.69 -0.51 4.21e-23 Intelligence (multi-trait analysis); CRC cis rs7666738 0.800 rs2839836 chr4:98970512 A/G cg17366294 chr4:99064904 C4orf37 0.44 7.45 0.38 8.04e-13 Colonoscopy-negative controls vs population controls; CRC cis rs2635047 1.000 rs2635049 chr18:44687303 C/T cg19077165 chr18:44547161 KATNAL2 0.47 7.81 0.4 7.88e-14 Educational attainment; CRC cis rs34779708 0.931 rs58159560 chr10:35351249 C/T cg03585969 chr10:35415529 CREM 0.67 8.91 0.44 3.47e-17 Inflammatory bowel disease;Crohn's disease; CRC trans rs6479874 0.680 rs2660213 chr10:52742229 C/A cg15483030 chr1:5935144 NPHP4 -0.71 -6.38 -0.33 6.07e-10 Migraine; CRC cis rs1008375 0.800 rs62296338 chr4:17613425 G/T cg16339924 chr4:17578868 LAP3 0.48 6.26 0.33 1.17e-9 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs7605827 0.704 rs2160695 chr2:15673478 T/A cg19274914 chr2:15703543 NA 0.39 5.87 0.31 1.07e-8 Educational attainment (years of education); CRC cis rs7917772 0.532 rs10748829 chr10:104527244 G/A cg22532475 chr10:104410764 TRIM8 0.34 5.8 0.3 1.58e-8 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC cis rs3806843 0.735 rs3776129 chr5:140072292 G/A cg19875535 chr5:140030758 IK -0.63 -10.38 -0.5 5.03e-22 Depressive symptoms (multi-trait analysis); CRC cis rs2019137 0.936 rs4849169 chr2:113953657 A/C cg21610815 chr2:113994035 PAX8;LOC654433;LOC440839 -0.45 -6.42 -0.33 4.82e-10 Lymphocyte counts; CRC cis rs4132509 1.000 rs320320 chr1:243835186 A/G cg21452805 chr1:244014465 NA 0.42 5.76 0.3 1.98e-8 RR interval (heart rate); CRC cis rs9443645 0.869 rs9361467 chr6:79621098 A/G cg09184832 chr6:79620586 NA -0.51 -9.58 -0.47 2.54e-19 Intelligence (multi-trait analysis); CRC cis rs853679 0.517 rs6922063 chr6:28094366 G/A cg12963246 chr6:28129442 ZNF389 0.5 5.98 0.31 5.71e-9 Depression; CRC cis rs1395 0.744 rs9653564 chr2:27472618 G/A cg14242246 chr2:27434262 C2orf28;SLC5A6 0.32 6.27 0.33 1.16e-9 Blood metabolite levels; CRC cis rs7213347 0.707 rs9898390 chr17:2177484 C/G cg15816464 chr17:2026533 SMG6 0.37 6.16 0.32 2.12e-9 Total body bone mineral density; CRC cis rs7772486 0.875 rs2777479 chr6:146309178 C/A cg23711669 chr6:146136114 FBXO30 0.63 10.57 0.5 1.12e-22 Lobe attachment (rater-scored or self-reported); CRC cis rs17253792 0.822 rs10149408 chr14:56046075 G/A cg01858014 chr14:56050164 KTN1 -0.87 -7.54 -0.38 4.73e-13 Putamen volume; CRC cis rs995000 0.899 rs11207985 chr1:63013786 A/G cg19896129 chr1:63156450 NA -0.44 -6.82 -0.35 4.3e-11 Triglyceride levels; CRC cis rs354033 0.959 rs354041 chr7:149297035 A/C cg24335155 chr7:149193227 ZNF746 0.39 6.2 0.32 1.65e-9 Multiple sclerosis; CRC cis rs861020 1.000 rs680923 chr1:209986672 T/C cg09163369 chr1:210001066 C1orf107 0.6 7.74 0.39 1.26e-13 Orofacial clefts; CRC cis rs4073582 0.595 rs474005 chr11:66033301 C/T cg14036092 chr11:66035641 RAB1B 0.57 9.24 0.45 3.19e-18 Gout; CRC trans rs4263408 0.934 rs9683743 chr4:39703194 A/C cg04923388 chr5:41904550 C5orf51 -0.42 -6.25 -0.33 1.3e-9 Plasma amyloid beta peptide concentrations (ABx-40); CRC cis rs7089973 0.646 rs35453961 chr10:116638166 T/C cg23260525 chr10:116636907 FAM160B1 0.36 8.02 0.4 1.89e-14 Bipolar disorder or attention deficit hyperactivity disorder; CRC trans rs1814175 0.781 rs12286395 chr11:49954062 C/G cg03929089 chr4:120376271 NA -0.94 -17.92 -0.7 1.32e-50 Height; CRC cis rs1552244 0.832 rs67145301 chr3:10197314 G/A cg00166722 chr3:10149974 C3orf24 0.69 7.99 0.4 2.25e-14 Alzheimer's disease; CRC cis rs9649213 0.593 rs35941058 chr7:97918159 T/C cg21770322 chr7:97807741 LMTK2 0.54 9.03 0.45 1.52e-17 Prostate cancer (SNP x SNP interaction); CRC trans rs2727020 0.704 rs2988340 chr11:49176057 C/T cg03929089 chr4:120376271 NA -0.72 -11.23 -0.53 5.47e-25 Coronary artery disease; CRC cis rs9372498 0.536 rs9489407 chr6:118792337 A/T cg24463073 chr6:118973353 C6orf204 -0.51 -7.0 -0.36 1.44e-11 Diastolic blood pressure; CRC cis rs11971779 0.715 rs6954219 chr7:139065110 G/C cg23387468 chr7:139079360 LUC7L2 0.41 7.04 0.36 1.14e-11 Diisocyanate-induced asthma; CRC cis rs34172651 0.583 rs200541 chr16:24733141 A/G cg06505273 chr16:24850292 NA -0.48 -5.86 -0.31 1.15e-8 Intelligence (multi-trait analysis); CRC cis rs7224737 1.000 rs7219220 chr17:40294280 T/C cg02450064 chr17:40260053 DHX58 -0.42 -6.11 -0.32 2.88e-9 Fibrinogen levels; CRC cis rs3806843 0.576 rs246045 chr5:140329884 C/T cg19875535 chr5:140030758 IK 0.39 6.02 0.31 4.67e-9 Depressive symptoms (multi-trait analysis); CRC cis rs6502050 0.777 rs4625783 chr17:80086395 T/C cg11859384 chr17:80120422 CCDC57 0.37 5.83 0.31 1.36e-8 Life satisfaction; CRC cis rs734999 1.000 rs2016366 chr1:2513678 A/T cg18854424 chr1:2615690 NA 0.39 7.55 0.38 4.32e-13 Ulcerative colitis; CRC cis rs10986311 0.802 rs7049097 chr9:127110457 G/A cg14243010 chr9:127117328 LOC100129034;PSMB7 0.41 6.17 0.32 2.04e-9 Vitiligo; CRC cis rs1401999 0.628 rs7639048 chr3:183746044 A/G cg01324343 chr3:183735012 ABCC5 0.75 13.67 0.6 5.57e-34 Anterior chamber depth; CRC cis rs6502050 0.764 rs28676462 chr17:80105100 G/C cg25804541 chr17:80189381 SLC16A3 -0.31 -5.97 -0.31 6.08e-9 Life satisfaction; CRC cis rs12325245 0.536 rs12931124 chr16:58620063 G/A cg01472538 chr16:58549086 SETD6 1.12 7.38 0.38 1.3e-12 Schizophrenia; CRC trans rs10504229 1.000 rs76023408 chr8:58193345 A/G cg04077850 chr5:125800366 GRAMD3 0.37 6.24 0.33 1.38e-9 Developmental language disorder (linguistic errors); CRC cis rs6499255 1.000 rs6499255 chr16:69830328 A/G cg00738113 chr16:70207722 CLEC18C -0.44 -6.65 -0.34 1.23e-10 IgE levels; CRC cis rs4731207 0.624 rs1031955 chr7:124710858 G/C cg23710748 chr7:124431027 NA -0.4 -6.28 -0.33 1.07e-9 Cutaneous malignant melanoma; CRC cis rs12230513 0.732 rs61957760 chr12:55859957 G/T cg19537932 chr12:55886519 OR6C68 -0.72 -9.22 -0.45 3.61e-18 Contrast sensitivity; CRC cis rs2243480 1.000 rs12698509 chr7:65418876 C/T cg12463550 chr7:65579703 CRCP 0.61 6.0 0.31 5.22e-9 Diabetic kidney disease; CRC cis rs2836974 0.565 rs34304022 chr21:40579619 G/A cg11890956 chr21:40555474 PSMG1 0.74 7.93 0.4 3.51e-14 Cognitive function; CRC trans rs9329221 0.537 rs1484640 chr8:9983243 G/T cg06636001 chr8:8085503 FLJ10661 0.45 6.6 0.34 1.69e-10 Neuroticism; CRC cis rs4819052 0.959 rs8130866 chr21:46672112 G/A cg19498844 chr21:46707878 POFUT2;LOC642852 0.8 10.8 0.51 1.8e-23 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs7937682 0.883 rs659529 chr11:111436896 T/A cg19812747 chr11:111475976 SIK2 -0.53 -8.86 -0.44 5.06e-17 Primary sclerosing cholangitis; CRC cis rs9308731 0.644 rs7577824 chr2:111876763 G/A cg18646521 chr2:111875858 NA 0.37 5.85 0.31 1.19e-8 Chronic lymphocytic leukemia; CRC cis rs6973256 0.897 rs7777805 chr7:133337074 T/C cg10665199 chr7:133106180 EXOC4 -0.37 -5.66 -0.3 3.26e-8 Intelligence (multi-trait analysis); CRC cis rs11945232 1.000 rs11945232 chr4:88342369 A/G cg23841344 chr4:88312519 HSD17B11 -0.49 -6.73 -0.35 7.53e-11 Intelligence (multi-trait analysis); CRC cis rs711245 0.572 rs3821150 chr2:36795233 G/A cg09467607 chr2:36825704 FEZ2 0.59 8.69 0.43 1.73e-16 Height; CRC cis rs798766 0.903 rs798726 chr4:1685211 C/T cg02089348 chr4:1724449 TMEM129;TACC3 0.42 6.04 0.32 4.26e-9 Bladder cancer;Urinary bladder cancer; CRC trans rs61931739 0.500 rs11053217 chr12:34470036 A/C cg13010199 chr12:38710504 ALG10B 0.44 6.29 0.33 1e-9 Morning vs. evening chronotype; CRC cis rs17270561 0.525 rs12201678 chr6:25978993 C/T cg16482183 chr6:26056742 HIST1H1C 1.06 12.3 0.56 7.46e-29 Iron status biomarkers; CRC cis rs6570726 0.818 rs399516 chr6:145810849 C/A cg05347473 chr6:146136440 FBXO30 0.35 5.64 0.3 3.57e-8 Lobe attachment (rater-scored or self-reported); CRC cis rs7918232 0.941 rs788210 chr10:27476948 T/C cg14442939 chr10:27389572 ANKRD26 -0.85 -9.22 -0.45 3.76e-18 Breast cancer; CRC cis rs2952156 0.920 rs1476278 chr17:37836243 C/T cg07936489 chr17:37558343 FBXL20 -0.45 -6.47 -0.34 3.48e-10 Asthma; CRC cis rs6951245 0.554 rs2070118 chr7:1132505 G/A cg07217954 chr7:1067459 C7orf50 0.49 5.8 0.3 1.6e-8 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs1707322 0.827 rs6683274 chr1:46241638 T/G cg06784218 chr1:46089804 CCDC17 0.62 11.25 0.53 4.6e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs1448094 0.511 rs1993807 chr12:86146833 A/G cg19622623 chr12:86230825 RASSF9 0.4 6.15 0.32 2.22e-9 Major depressive disorder; CRC cis rs3859192 0.539 rs2302774 chr17:38183090 G/T cg17344932 chr17:38183730 MED24;SNORD124 0.87 17.62 0.7 2.1e-49 White blood cell count; CRC cis rs6500602 0.727 rs11076837 chr16:4569440 C/T cg08645402 chr16:4508243 NA 0.62 11.18 0.52 8.15e-25 Schizophrenia; CRC cis rs12477438 0.798 rs6736064 chr2:99658201 G/A cg26064155 chr2:99771622 LIPT1;TSGA10 -0.79 -11.26 -0.53 4.44e-25 Chronic sinus infection; CRC cis rs7605827 0.930 rs6753645 chr2:15539556 G/C cg19274914 chr2:15703543 NA 0.4 5.94 0.31 7.2e-9 Educational attainment (years of education); CRC cis rs2486012 0.737 rs6691988 chr1:44254402 A/G cg12908607 chr1:44402522 ARTN 0.41 6.08 0.32 3.25e-9 Intelligence (multi-trait analysis); CRC cis rs9611565 0.918 rs9611561 chr22:41757234 C/G cg06634786 chr22:41940651 POLR3H -0.63 -7.43 -0.38 9.66e-13 Vitiligo; CRC cis rs6570726 0.846 rs439035 chr6:145887990 G/C cg23711669 chr6:146136114 FBXO30 0.67 11.33 0.53 2.35e-25 Lobe attachment (rater-scored or self-reported); CRC cis rs4731207 0.596 rs6466990 chr7:124691512 C/T cg23710748 chr7:124431027 NA -0.4 -6.28 -0.33 1.09e-9 Cutaneous malignant melanoma; CRC cis rs780096 0.506 rs1262430 chr2:27673798 T/C cg12648201 chr2:27665141 KRTCAP3 -0.31 -6.23 -0.32 1.41e-9 Total body bone mineral density; CRC cis rs13108904 0.935 rs4974575 chr4:1252028 A/G cg02018176 chr4:1364513 KIAA1530 0.4 6.63 0.34 1.37e-10 Obesity-related traits; CRC cis rs9733 0.596 rs11204697 chr1:150658971 C/T cg15448220 chr1:150897856 SETDB1 0.45 6.43 0.33 4.42e-10 Tonsillectomy; CRC cis rs853679 0.517 rs9393894 chr6:28112562 A/G cg15845792 chr6:28175446 NA 1.04 13.89 0.61 7.67e-35 Depression; CRC cis rs2204008 0.502 rs2387275 chr12:38142836 G/A cg26384229 chr12:38710491 ALG10B 0.7 9.27 0.45 2.6e-18 Bladder cancer; CRC cis rs11122272 0.701 rs2474628 chr1:231526000 C/T cg06096015 chr1:231504339 EGLN1 0.4 5.98 0.31 5.78e-9 Hemoglobin concentration; CRC cis rs1707322 1.000 rs34694458 chr1:46332696 G/A cg06784218 chr1:46089804 CCDC17 0.5 8.75 0.43 1.13e-16 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg16078938 chr7:6769406 NA 0.39 6.0 0.31 5.19e-9 Liver disease severity in Alagille syndrome; CRC trans rs1005277 0.579 rs1780137 chr10:38501475 C/G cg27523141 chr10:43048294 ZNF37B 0.45 6.5 0.34 2.94e-10 Extrinsic epigenetic age acceleration; CRC trans rs10506458 0.915 rs17687426 chr12:63397900 G/C cg22491629 chr6:157744540 C6orf35 -0.77 -9.22 -0.45 3.61e-18 Hemostatic factors and hematological phenotypes; CRC cis rs6938 0.514 rs56338926 chr15:75259335 C/A cg17294928 chr15:75287854 SCAMP5 0.47 6.75 0.35 6.69e-11 Breast cancer; CRC cis rs3785574 0.962 rs13030 chr17:61908556 C/T cg25654072 chr17:61904446 PSMC5;FTSJ3 0.44 6.01 0.31 4.82e-9 Height; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg05682094 chr20:5108045 PCNA;CDS2 0.43 6.25 0.33 1.25e-9 Intelligence (multi-trait analysis); CRC cis rs2204008 0.603 rs4397954 chr12:38089157 T/C cg26384229 chr12:38710491 ALG10B 0.7 8.96 0.44 2.46e-17 Bladder cancer; CRC cis rs9902453 0.902 rs4075014 chr17:28305674 C/T cg26525008 chr17:28256777 EFCAB5;SSH2 0.58 8.8 0.44 7.96e-17 Coffee consumption (cups per day); CRC cis rs6681460 1.000 rs7532173 chr1:67086111 A/G cg02459107 chr1:67143332 SGIP1 0.4 6.78 0.35 5.6e-11 Presence of antiphospholipid antibodies; CRC cis rs13191362 0.507 rs6907151 chr6:163200701 T/A cg21926612 chr6:163149169 PACRG;PARK2 0.57 8.95 0.44 2.71e-17 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs736408 0.561 rs2276815 chr3:52853747 C/G cg15147215 chr3:52552868 STAB1 -0.42 -5.94 -0.31 7.43e-9 Bipolar disorder; CRC trans rs8073060 0.586 rs72829922 chr17:34044809 G/A cg19694781 chr19:47549865 TMEM160 1.08 14.73 0.63 4.38e-38 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; CRC cis rs8180040 1.000 rs2159400 chr3:47375890 T/C cg10298567 chr3:47292165 KIF9 0.44 7.19 0.37 4.39e-12 Colorectal cancer; CRC cis rs7635838 0.586 rs347617 chr3:11278211 C/T cg00170343 chr3:11313890 ATG7 0.59 9.13 0.45 7.15e-18 HDL cholesterol; CRC cis rs7191700 0.578 rs243324 chr16:11354970 A/G cg00044050 chr16:11439710 C16orf75 0.54 7.83 0.4 6.59e-14 Multiple sclerosis; CRC cis rs2075371 1.000 rs1862050 chr7:133980999 T/C cg20476274 chr7:133979776 SLC35B4 0.82 15.15 0.64 1.04e-39 Mean platelet volume; CRC trans rs9329221 0.662 rs13254942 chr8:10257678 C/T cg08975724 chr8:8085496 FLJ10661 -0.42 -6.53 -0.34 2.54e-10 Neuroticism; CRC cis rs3087591 0.879 rs12103564 chr17:29607243 A/T cg24425628 chr17:29625626 OMG;NF1 -0.82 -14.37 -0.62 1.11e-36 Hip circumference; CRC cis rs10779751 1.000 rs11121704 chr1:11293959 A/G cg08854313 chr1:11322531 MTOR -0.67 -9.83 -0.48 3.77e-20 Body mass index; CRC cis rs17270561 0.609 rs4711103 chr6:25742224 C/T cg16482183 chr6:26056742 HIST1H1C 0.83 10.69 0.51 4.46e-23 Iron status biomarkers; CRC cis rs2898681 0.519 rs6554057 chr4:53730147 A/T cg21521518 chr4:53727714 RASL11B 0.41 6.07 0.32 3.56e-9 Optic nerve measurement (cup area); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg26251429 chr2:28113398 BRE;RBKS;LOC100302650 0.38 6.01 0.31 4.85e-9 Liver disease severity in Alagille syndrome; CRC cis rs6089584 0.889 rs6142923 chr20:60596617 C/T cg18761221 chr20:60518478 NA -0.54 -8.39 -0.42 1.41e-15 Body mass index; CRC cis rs8067545 0.641 rs397969 chr17:19804247 T/C cg04132472 chr17:19861366 AKAP10 0.42 6.31 0.33 9.1e-10 Schizophrenia; CRC cis rs9372498 0.536 rs62421539 chr6:118730559 C/A cg22561889 chr6:118971681 C6orf204 0.53 6.92 0.36 2.43e-11 Diastolic blood pressure; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg19125323 chr17:74733470 MIR636;SFRS2;MFSD11 0.38 5.98 0.31 5.82e-9 Liver disease severity in Alagille syndrome; CRC cis rs12682352 0.602 rs635594 chr8:8613387 C/T cg08975724 chr8:8085496 FLJ10661 -0.42 -5.96 -0.31 6.36e-9 Neuroticism; CRC cis rs3820928 1.000 rs7561378 chr2:227772248 T/C cg11843606 chr2:227700838 RHBDD1 -0.41 -5.91 -0.31 8.42e-9 Pulmonary function; CRC cis rs6500395 1.000 rs8059819 chr16:48682834 A/G cg04672837 chr16:48644449 N4BP1 -0.44 -6.56 -0.34 2.14e-10 Response to tocilizumab in rheumatoid arthritis; CRC cis rs7927592 0.871 rs11228284 chr11:68322767 A/T cg16797656 chr11:68205561 LRP5 0.36 5.71 0.3 2.47e-8 Total body bone mineral density; CRC cis rs4713118 0.662 rs9468271 chr6:28024570 A/G cg18032046 chr6:28092343 ZSCAN16 -0.5 -6.37 -0.33 6.28e-10 Parkinson's disease; CRC cis rs868943 0.582 rs12214665 chr6:116466990 G/A cg15226275 chr6:116381976 FRK 0.26 6.08 0.32 3.31e-9 Total cholesterol levels; CRC trans rs6550704 0.687 rs9865314 chr3:22634337 A/G cg20357023 chr2:178417605 TTC30B -0.41 -6.03 -0.32 4.45e-9 Daytime sleep phenotypes; CRC cis rs6570726 0.905 rs421032 chr6:145827771 A/G cg13319975 chr6:146136371 FBXO30 -0.38 -5.8 -0.3 1.53e-8 Lobe attachment (rater-scored or self-reported); CRC cis rs208515 0.525 rs10944870 chr6:66687757 G/C cg07460842 chr6:66804631 NA 0.95 11.96 0.55 1.24e-27 Exhaled nitric oxide levels; CRC cis rs1223397 0.651 rs2496148 chr6:13313553 A/G cg20827128 chr6:13274284 PHACTR1 0.38 5.78 0.3 1.75e-8 Blood pressure; CRC cis rs7647973 0.626 rs62262722 chr3:49769419 G/C cg13072238 chr3:49761600 GMPPB 0.53 5.81 0.31 1.48e-8 Menarche (age at onset); CRC cis rs1552244 0.872 rs35988239 chr3:10074145 G/T cg13047869 chr3:10149882 C3orf24 0.52 6.06 0.32 3.74e-9 Alzheimer's disease; CRC trans rs561341 1.000 rs501312 chr17:30329066 A/G cg27661571 chr11:113659931 NA -0.94 -10.92 -0.52 7.04e-24 Hip circumference adjusted for BMI; CRC cis rs1552244 0.935 rs4441636 chr3:10083876 G/A cg18598329 chr3:10140678 FANCD2;C3orf24 -0.89 -11.83 -0.55 3.95e-27 Alzheimer's disease; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg09284707 chr11:107799080 RAB39 0.32 6.41 0.33 4.95e-10 Liver disease severity in Alagille syndrome; CRC cis rs55665837 0.520 rs10766189 chr11:14733923 G/A cg19336497 chr11:14380999 RRAS2 -0.34 -5.69 -0.3 2.76e-8 Vitamin D levels; CRC cis rs4474465 0.790 rs4945292 chr11:78254424 T/A cg02023728 chr11:77925099 USP35 -0.38 -6.33 -0.33 7.88e-10 Alzheimer's disease (survival time); CRC cis rs11212617 0.837 rs2070661 chr11:108043988 C/T cg14761454 chr11:108092087 ATM;NPAT 0.4 6.02 0.32 4.6e-9 Response to metformin in type 2 diabetes (glycemic); CRC cis rs875971 0.862 rs4368860 chr7:65608482 C/G cg11764359 chr7:65958608 NA -0.61 -9.39 -0.46 1.02e-18 Aortic root size; CRC cis rs2380220 0.808 rs2716070 chr6:95912375 T/C cg04719120 chr6:96025338 MANEA -0.53 -5.88 -0.31 9.93e-9 Behavioural disinhibition (generation interaction); CRC cis rs9329221 0.741 rs534523 chr8:9884999 C/G cg27411982 chr8:10470053 RP1L1 -0.37 -6.0 -0.31 5.21e-9 Neuroticism; CRC cis rs3793683 0.928 rs2148666 chr10:134553785 A/G cg27286337 chr10:134555280 INPP5A 0.89 17.32 0.69 3.19e-48 Migraine; CRC cis rs9818758 0.607 rs73082362 chr3:49113729 C/T cg00383909 chr3:49044727 WDR6 1.36 11.14 0.52 1.1e-24 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; CRC cis rs2933343 0.679 rs789254 chr3:128574593 A/G cg11901034 chr3:128598214 ACAD9 -0.57 -8.32 -0.42 2.41e-15 IgG glycosylation; CRC cis rs7945705 0.783 rs11042125 chr11:8938049 A/T cg14711859 chr11:8959438 ASCL3 0.46 7.53 0.38 4.82e-13 Hemoglobin concentration; CRC cis rs1799949 1.000 rs8176109 chr17:41265776 A/G cg23758822 chr17:41437982 NA 0.79 13.38 0.59 6.65e-33 Menopause (age at onset); CRC cis rs11098499 0.954 rs10017543 chr4:120321420 G/A cg24375607 chr4:120327624 NA 0.5 7.71 0.39 1.55e-13 Corneal astigmatism; CRC cis rs11627756 0.958 rs2146429 chr14:103071816 A/T cg12046867 chr14:103022105 NA -0.42 -5.77 -0.3 1.81e-8 Mean platelet volume; CRC cis rs2739330 0.760 rs5751760 chr22:24243573 G/A cg11060661 chr22:24314208 DDT;DDTL 0.49 8.45 0.42 9.82e-16 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs7225537 0.559 rs7214429 chr17:17059872 A/G cg26176665 chr17:16994978 MPRIP -0.36 -5.81 -0.3 1.5e-8 Mean platelet volume; CRC cis rs6866344 0.570 rs1132338 chr5:178139442 T/G cg03877680 chr5:178157825 ZNF354A 0.74 10.56 0.5 1.18e-22 Neutrophil percentage of white cells; CRC cis rs3785574 0.962 rs13030 chr17:61908556 C/T cg06873352 chr17:61820015 STRADA 0.49 7.77 0.39 1e-13 Height; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg01074628 chr11:74204917 LIPT2 0.43 6.16 0.32 2.08e-9 Intelligence (multi-trait analysis); CRC cis rs62408225 1.000 rs62408237 chr6:90980345 C/G cg06866423 chr6:90926672 BACH2 0.47 7.85 0.4 6.01e-14 Eosinophil counts;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC cis rs57221529 0.655 rs11948381 chr5:568413 A/T cg09021430 chr5:549028 NA -0.86 -11.19 -0.52 7.81e-25 Lung disease severity in cystic fibrosis; CRC trans rs7730934 1.000 rs6894414 chr5:55252495 A/G cg10323188 chr3:28613979 NA 0.52 6.11 0.32 2.84e-9 Blood protein levels; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg00222291 chr16:22385662 CDR2 0.41 6.21 0.32 1.58e-9 Liver disease severity in Alagille syndrome; CRC cis rs4555082 0.718 rs2816619 chr14:105732551 G/C cg18132624 chr14:105716052 BTBD6;BRF1 -0.49 -7.78 -0.39 9.16e-14 Mean platelet volume;Platelet distribution width; CRC cis rs1005277 0.579 rs2474563 chr10:38375938 T/C cg00409905 chr10:38381863 ZNF37A -0.67 -11.27 -0.53 3.95e-25 Extrinsic epigenetic age acceleration; CRC cis rs10751667 0.643 rs7394524 chr11:933865 T/C cg06064525 chr11:970664 AP2A2 -0.34 -6.75 -0.35 6.62e-11 Alzheimer's disease (late onset); CRC cis rs16852403 0.548 rs623225 chr1:178211322 C/A cg00404053 chr1:178313656 RASAL2 -0.48 -6.37 -0.33 6.21e-10 Childhood ear infection; CRC cis rs9467773 0.595 rs3799379 chr6:26404694 C/T cg09904177 chr6:26538194 HMGN4 -0.42 -5.81 -0.3 1.51e-8 Intelligence (multi-trait analysis); CRC cis rs10504229 0.683 rs2318147 chr8:58114931 C/T cg08219700 chr8:58056026 NA 0.53 6.35 0.33 7.35e-10 Developmental language disorder (linguistic errors); CRC cis rs3733585 0.673 rs4235348 chr4:9951968 T/C cg00071950 chr4:10020882 SLC2A9 -0.55 -9.74 -0.47 7.09e-20 Cleft plate (environmental tobacco smoke interaction); CRC cis rs2742540 0.503 rs2653556 chr11:8906636 C/G cg14711859 chr11:8959438 ASCL3 0.55 9.86 0.48 3e-20 Hematocrit; CRC cis rs7312933 0.524 rs11181465 chr12:42765098 T/G cg19980929 chr12:42632907 YAF2 0.41 6.18 0.32 1.86e-9 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CRC cis rs798554 0.797 rs1182174 chr7:2875420 G/A cg04166393 chr7:2884313 GNA12 0.54 7.28 0.37 2.5e-12 Height; CRC trans rs1814175 0.754 rs7103235 chr11:49699191 A/G cg15704280 chr7:45808275 SEPT13 -0.85 -13.3 -0.59 1.29e-32 Height; CRC cis rs10883723 0.810 rs3818470 chr10:104263675 T/C cg11453585 chr10:104263688 ACTR1A;SUFU 0.92 17.58 0.7 2.89e-49 Allergic disease (asthma, hay fever or eczema); CRC cis rs4363385 0.818 rs653332 chr1:153010481 C/T cg25856811 chr1:152973957 SPRR3 -0.25 -6.99 -0.36 1.51e-11 Inflammatory skin disease; CRC trans rs7267979 0.834 rs6115100 chr20:25225938 C/A cg17903999 chr18:56338584 MALT1 -0.4 -6.4 -0.33 5.39e-10 Liver enzyme levels (alkaline phosphatase); CRC cis rs875971 0.540 rs736270 chr7:65428822 T/C cg11764359 chr7:65958608 NA 0.52 7.64 0.39 2.33e-13 Aortic root size; CRC cis rs4665809 1.000 rs750451 chr2:26324241 G/A cg25036284 chr2:26402008 FAM59B -0.46 -5.97 -0.31 6e-9 Gut microbiome composition (summer); CRC cis rs28386778 0.897 rs9915552 chr17:61869095 G/A cg07362569 chr17:61921086 SMARCD2 0.37 5.7 0.3 2.7e-8 Prudent dietary pattern; CRC cis rs3790844 0.876 rs61486545 chr1:200008337 G/A cg13229857 chr1:200006247 NR5A2 0.51 7.1 0.36 7.83e-12 Pancreatic cancer; CRC cis rs6456156 0.586 rs10946208 chr6:167459596 C/T cg07741184 chr6:167504864 NA 0.42 7.22 0.37 3.58e-12 Primary biliary cholangitis; CRC cis rs7107770 0.663 rs893973 chr11:125073643 C/A cg27629782 chr11:125073726 PKNOX2 0.5 7.17 0.37 4.87e-12 Photic sneeze reflex; CRC cis rs1801251 0.963 rs13021246 chr2:233623111 T/C cg25237894 chr2:233734115 C2orf82 0.54 8.8 0.44 7.77e-17 Coronary artery disease; CRC cis rs1799949 0.930 rs56729776 chr17:41422131 C/T cg05368731 chr17:41323189 NBR1 0.65 9.39 0.46 1.03e-18 Menopause (age at onset); CRC cis rs6540556 0.723 rs12034758 chr1:209920545 G/A cg23920097 chr1:209922102 NA -0.54 -6.19 -0.32 1.79e-9 Red blood cell count; CRC cis rs7959452 0.535 rs4761228 chr12:69682327 G/A cg22834771 chr12:69754056 YEATS4 -0.41 -5.97 -0.31 6.17e-9 Blood protein levels; CRC cis rs6500602 0.702 rs2304634 chr16:4500544 C/T cg14951292 chr16:4525986 HMOX2;NMRAL1 0.58 9.01 0.44 1.75e-17 Schizophrenia; CRC cis rs2223471 0.692 rs9357674 chr6:50779740 A/G cg03432817 chr6:50765336 NA 0.37 5.8 0.3 1.58e-8 Subcutaneous adipose tissue; CRC cis rs9443645 0.527 rs1413969 chr6:79790982 A/G cg09184832 chr6:79620586 NA -0.43 -7.32 -0.37 1.87e-12 Intelligence (multi-trait analysis); CRC cis rs7659604 1.000 rs28618203 chr4:122663935 T/C cg20573242 chr4:122745356 CCNA2 0.42 6.29 0.33 9.89e-10 Type 2 diabetes; CRC cis rs2280018 0.963 rs12928424 chr16:15150773 C/G cg27102117 chr16:15229624 NA 0.39 6.77 0.35 5.97e-11 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid);Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CRC trans rs4263408 0.934 rs9683743 chr4:39703194 A/C cg12279128 chr22:24109851 CHCHD10 -0.43 -6.48 -0.34 3.28e-10 Plasma amyloid beta peptide concentrations (ABx-40); CRC cis rs2836974 0.796 rs77153312 chr21:40695499 G/A cg17971929 chr21:40555470 PSMG1 0.76 10.29 0.49 9.95e-22 Cognitive function; CRC cis rs1904096 0.506 rs10028613 chr4:95223698 T/C cg11021082 chr4:95130006 SMARCAD1 -0.48 -6.97 -0.36 1.73e-11 Type 2 diabetes; CRC cis rs2404602 0.692 rs8043474 chr15:76974723 T/C cg22467129 chr15:76604101 ETFA -0.4 -6.71 -0.35 8.3e-11 Blood metabolite levels; CRC cis rs4665809 0.590 rs35615763 chr2:26468778 C/G cg08067268 chr2:26466485 HADHB;HADHA 0.65 8.34 0.42 2e-15 Gut microbiome composition (summer); CRC trans rs6550704 0.687 rs9865314 chr3:22634337 A/G cg08703324 chr15:43785408 TP53BP1 -0.41 -6.21 -0.32 1.61e-9 Daytime sleep phenotypes; CRC cis rs2985684 0.947 rs1952013 chr14:50087357 C/G cg04989706 chr14:50066350 PPIL5 -0.55 -7.53 -0.38 4.78e-13 Carotid intima media thickness; CRC cis rs185694 1.000 rs202099 chr13:30896874 C/T cg04551440 chr13:30881194 KATNAL1 -0.61 -6.33 -0.33 7.8e-10 Antineutrophil cytoplasmic antibody-associated vasculitis; CRC cis rs6598955 0.671 rs6681452 chr1:26621101 G/A cg00852783 chr1:26633632 UBXN11 -0.51 -5.98 -0.31 5.68e-9 Obesity-related traits; CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg21257117 chr11:65029643 POLA2 -0.51 -6.09 -0.32 3.21e-9 Diisocyanate-induced asthma; CRC cis rs35146811 0.659 rs863450 chr7:99821685 C/T cg00553149 chr7:99775558 STAG3;GPC2 -0.25 -5.74 -0.3 2.16e-8 Coronary artery disease; CRC cis rs10504229 0.683 rs10504221 chr8:58140256 A/G cg05313129 chr8:58192883 C8orf71 -0.43 -6.11 -0.32 2.74e-9 Developmental language disorder (linguistic errors); CRC cis rs7772486 0.790 rs9403750 chr6:146167762 G/A cg13319975 chr6:146136371 FBXO30 -0.41 -6.19 -0.32 1.77e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs4665809 0.941 rs11126336 chr2:26245931 C/T cg26119090 chr2:26468346 HADHA;HADHB -0.61 -7.74 -0.39 1.27e-13 Gut microbiome composition (summer); CRC cis rs7086627 0.515 rs7077373 chr10:82211615 C/T cg09626299 chr10:82213104 TSPAN14 -0.37 -6.23 -0.33 1.39e-9 Post bronchodilator FEV1; CRC trans rs9929218 0.529 rs11075694 chr16:68730366 C/T cg04657470 chr2:198365150 HSPE1;HSPD1 1.06 21.61 0.77 4.37e-65 Colorectal cancer; CRC cis rs6502050 0.835 rs62080004 chr17:80079079 C/T cg02741985 chr17:80059408 CCDC57 -0.44 -7.17 -0.37 4.96e-12 Life satisfaction; CRC cis rs2011503 1.000 rs78176666 chr19:19636702 T/C cg11584989 chr19:19387371 SF4 0.58 6.48 0.34 3.27e-10 Bipolar disorder; CRC cis rs2243480 1.000 rs1167613 chr7:65487439 C/T cg25985355 chr7:65971099 NA -0.5 -5.73 -0.3 2.25e-8 Diabetic kidney disease; CRC cis rs1552244 1.000 rs12152515 chr3:10143976 C/T cg10729496 chr3:10149963 C3orf24 0.49 6.8 0.35 4.85e-11 Alzheimer's disease; CRC cis rs7618915 0.621 rs6788993 chr3:52605136 T/C cg08222913 chr3:52553049 STAB1 -0.35 -6.47 -0.34 3.65e-10 Bipolar disorder; CRC cis rs274567 0.501 rs274571 chr5:131712125 A/G cg04518342 chr5:131593106 PDLIM4 -0.44 -7.17 -0.37 5.09e-12 Blood metabolite levels; CRC cis rs6499255 0.951 rs10852457 chr16:69607853 C/T cg15192750 chr16:69999425 NA 0.57 7.72 0.39 1.42e-13 IgE levels; CRC cis rs9556958 0.708 rs4772092 chr13:99166614 A/G cg07423050 chr13:99094983 FARP1 -0.43 -6.49 -0.34 3.24e-10 Educational attainment (years of education); CRC trans rs10504229 1.000 rs58947041 chr8:58188934 G/A cg04077850 chr5:125800366 GRAMD3 0.37 6.23 0.32 1.39e-9 Developmental language disorder (linguistic errors); CRC cis rs3091242 0.933 rs11249250 chr1:25767609 G/A cg20684491 chr1:25596433 NA 0.43 7.46 0.38 7.77e-13 Erythrocyte sedimentation rate; CRC cis rs61472021 1 rs61472021 chr6:26090025 T/C cg08501292 chr6:25962987 TRIM38 0.56 5.92 0.31 7.89e-9 Autism spectrum disorder or schizophrenia; CRC cis rs13108904 0.935 rs6853002 chr4:1295991 C/T cg19318889 chr4:1322082 MAEA 0.4 5.97 0.31 6.21e-9 Obesity-related traits; CRC cis rs6762 0.748 rs3059 chr11:840319 C/T cg03116740 chr11:841335 TSPAN4;POLR2L -0.41 -6.94 -0.36 2.08e-11 Mean platelet volume; CRC cis rs926938 0.563 rs360661 chr1:115455280 G/A cg12756093 chr1:115239321 AMPD1 0.56 8.36 0.42 1.83e-15 Autism; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg21195395 chr19:5981162 NA -0.44 -7.36 -0.38 1.48e-12 Liver disease severity in Alagille syndrome; CRC cis rs7586879 1.000 rs1865687 chr2:25112885 G/A cg04586622 chr2:25135609 ADCY3 -0.43 -7.19 -0.37 4.46e-12 Body mass index; CRC cis rs12802200 0.535 rs35391985 chr11:570280 T/C cg01842473 chr11:617407 IRF7;MUPCDH -0.48 -6.31 -0.33 8.85e-10 Systemic lupus erythematosus; CRC cis rs548181 0.736 rs543389 chr11:125464841 A/G cg03464685 chr11:125439445 EI24 1.14 11.67 0.54 1.46e-26 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs13108904 0.846 rs12643212 chr4:1224948 A/G cg21620606 chr4:1342894 KIAA1530 0.34 5.84 0.31 1.24e-8 Obesity-related traits; CRC cis rs2243480 1.000 rs58669269 chr7:65951953 T/C cg18252515 chr7:66147081 NA -1.27 -14.68 -0.63 7.35e-38 Diabetic kidney disease; CRC cis rs9902453 0.967 rs1906450 chr17:28515744 A/T cg26525008 chr17:28256777 EFCAB5;SSH2 0.57 8.5 0.42 6.55e-16 Coffee consumption (cups per day); CRC cis rs7726839 0.555 rs4541696 chr5:581053 A/G cg09021430 chr5:549028 NA -0.88 -16.0 -0.66 5.02e-43 Obesity-related traits; CRC cis rs10979 0.571 rs6909701 chr6:143922918 C/G cg25407410 chr6:143891975 LOC285740 -0.59 -7.52 -0.38 5.32e-13 Hypospadias; CRC cis rs10078 0.515 rs2672739 chr5:443447 A/C cg07599136 chr5:415885 AHRR 0.58 5.84 0.31 1.24e-8 Fat distribution (HIV); CRC cis rs6921919 0.583 rs6907950 chr6:28370246 C/T cg21251018 chr6:28226885 NKAPL 0.41 6.0 0.31 5.12e-9 Autism spectrum disorder or schizophrenia; CRC cis rs1045714 0.779 rs3735113 chr7:2651563 G/A cg24848437 chr7:2645542 IQCE 0.63 6.26 0.33 1.21e-9 Urate levels in lean individuals; CRC cis rs1223397 0.651 rs202022 chr6:13302931 A/G cg07912922 chr6:13274314 PHACTR1 -0.38 -5.99 -0.31 5.39e-9 Blood pressure; CRC cis rs9381040 0.610 rs2294694 chr6:41046177 G/A cg03644281 chr6:41068752 NFYA;LOC221442 -0.43 -6.02 -0.32 4.63e-9 Alzheimer's disease (late onset); CRC cis rs400736 0.894 rs172811 chr1:8039949 A/G cg25007680 chr1:8021821 PARK7 0.53 7.57 0.39 3.68e-13 Response to antidepressants and depression; CRC cis rs853679 0.517 rs4713144 chr6:28106790 C/G cg03623178 chr6:28175578 NA 0.96 12.57 0.57 7.23e-30 Depression; CRC cis rs589448 0.902 rs2603090 chr12:69777188 G/A cg20891283 chr12:69753455 YEATS4 0.98 21.04 0.76 6.92e-63 Cerebrospinal fluid biomarker levels; CRC cis rs6565180 0.791 rs4247355 chr16:30392099 A/G cg17640201 chr16:30407289 ZNF48 0.83 13.81 0.61 1.53e-34 Tonsillectomy; CRC cis rs2455601 0.882 rs11042106 chr11:8896083 C/T cg21881798 chr11:8931708 C11orf17;ST5 0.55 6.26 0.33 1.22e-9 Schizophrenia; CRC cis rs12431939 0.744 rs12888250 chr14:51669195 C/G cg23942311 chr14:51606299 NA 0.49 6.79 0.35 5.35e-11 Cancer; CRC cis rs2739330 0.828 rs5760108 chr22:24252668 G/T cg18538332 chr22:24372958 LOC391322 -0.71 -11.18 -0.52 8.44e-25 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs12188164 0.930 rs72717440 chr5:449701 A/T cg26850624 chr5:429559 AHRR -0.81 -13.82 -0.61 1.41e-34 Cystic fibrosis severity; CRC cis rs62244186 0.659 rs7649834 chr3:44503732 C/T cg10263370 chr3:44754102 ZNF502 -0.36 -5.92 -0.31 7.94e-9 Depressive symptoms; CRC cis rs6089584 0.528 rs881994 chr20:60623931 G/A cg13770153 chr20:60521292 NA -0.44 -6.53 -0.34 2.51e-10 Body mass index; CRC cis rs6089584 0.854 rs8117075 chr20:60613766 T/C cg23262073 chr20:60523788 NA -0.47 -7.24 -0.37 3.29e-12 Body mass index; CRC cis rs9660992 0.508 rs113817010 chr1:205104581 C/A cg00857998 chr1:205179979 DSTYK 0.46 6.34 0.33 7.79e-10 Mean corpuscular volume;Mean platelet volume; CRC cis rs3858526 0.584 rs10742809 chr11:5862532 G/T cg05234568 chr11:5960015 NA 0.6 8.52 0.43 5.92e-16 DNA methylation (variation); CRC cis rs9649213 0.593 rs7797943 chr7:97946902 T/C cg21770322 chr7:97807741 LMTK2 0.5 8.12 0.41 9.48e-15 Prostate cancer (SNP x SNP interaction); CRC cis rs4285028 0.699 rs4676758 chr3:121583415 T/C cg20356878 chr3:121714668 ILDR1 0.49 6.94 0.36 2.11e-11 Multiple sclerosis; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg15655138 chr6:37139981 PIM1 0.46 6.4 0.33 5.39e-10 Response to antipsychotic treatment; CRC cis rs2011503 0.941 rs2315023 chr19:19413393 C/T cg11584989 chr19:19387371 SF4 0.56 6.43 0.33 4.42e-10 Bipolar disorder; CRC trans rs2710642 0.888 rs13418889 chr2:63079775 T/C cg05376469 chr2:102649931 NA -0.36 -6.03 -0.32 4.51e-9 LDL cholesterol levels;LDL cholesterol; CRC cis rs7677751 0.806 rs1800813 chr4:55094467 G/A cg17187183 chr4:55093834 PDGFRA 0.54 7.54 0.38 4.77e-13 Corneal astigmatism; CRC cis rs9443645 0.810 rs9448610 chr6:79739622 G/A cg09184832 chr6:79620586 NA -0.49 -8.82 -0.44 6.68e-17 Intelligence (multi-trait analysis); CRC cis rs8062405 0.698 rs7188071 chr16:28917644 T/C cg16576597 chr16:28551801 NUPR1 -0.48 -6.65 -0.34 1.19e-10 Cognitive ability (multi-trait analysis);Cognitive ability; CRC cis rs75920871 0.545 rs7939934 chr11:116861268 A/T cg01368799 chr11:117014884 PAFAH1B2 -0.43 -5.94 -0.31 7.08e-9 Subjective well-being; CRC cis rs881375 0.967 rs10435844 chr9:123668199 G/T cg00246817 chr9:123691163 NA -0.47 -6.04 -0.32 4.11e-9 Rheumatoid arthritis; CRC trans rs877282 0.583 rs11253424 chr10:813426 C/T cg22713356 chr15:30763199 NA 0.85 10.54 0.5 1.43e-22 Uric acid levels; CRC cis rs951366 0.789 rs823110 chr1:205701078 G/C cg07167872 chr1:205819463 PM20D1 0.76 11.55 0.54 4.05e-26 Menarche (age at onset); CRC cis rs8177253 0.965 rs4854762 chr3:133499063 A/G cg16262614 chr3:133464971 TF -0.32 -5.66 -0.3 3.36e-8 Iron status biomarkers; CRC cis rs2075671 0.855 rs11974395 chr7:100282538 G/A cg20848291 chr7:100343083 ZAN -0.67 -10.1 -0.49 4.64e-21 Other erythrocyte phenotypes; CRC trans rs9956878 0.555 rs8085188 chr18:73544676 A/G cg21211053 chr19:49496578 GYS1;RUVBL2 -0.38 -6.42 -0.33 4.67e-10 Obesity-related traits; CRC cis rs1552244 0.882 rs13088350 chr3:10044626 T/C cg02579736 chr3:10068473 FANCD2;CIDECP 0.93 12.04 0.55 6.69e-28 Alzheimer's disease; CRC cis rs7264396 0.690 rs2425180 chr20:34447160 G/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.6 -10.19 -0.49 2.18e-21 Total cholesterol levels; CRC trans rs2228479 0.850 rs17226498 chr16:89840631 T/C cg24644049 chr4:85504048 CDS1 0.92 7.68 0.39 1.79e-13 Skin colour saturation; CRC cis rs447 1.000 rs2067693 chr7:83759570 C/T cg22846510 chr7:83753280 SEMA3A -0.61 -7.79 -0.39 8.85e-14 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs1865760 0.508 rs9379820 chr6:26049924 T/C cg18357526 chr6:26021779 HIST1H4A 0.41 5.8 0.3 1.54e-8 Height; CRC cis rs2243480 1.000 rs316331 chr7:65604622 A/G cg25985355 chr7:65971099 NA 0.51 6.0 0.31 5.23e-9 Diabetic kidney disease; CRC cis rs7945705 0.818 rs2742552 chr11:8876852 C/T cg00186954 chr11:8933980 ST5;C11orf17 -0.49 -8.25 -0.41 3.74e-15 Hemoglobin concentration; CRC cis rs12479064 0.604 rs11893359 chr2:99954608 A/G cg26064155 chr2:99771622 LIPT1;TSGA10 -0.61 -7.57 -0.39 3.84e-13 Chronic sinus infection; CRC cis rs10504229 0.593 rs79874994 chr8:57993709 C/A cg21724239 chr8:58056113 NA 0.75 9.05 0.45 1.3e-17 Developmental language disorder (linguistic errors); CRC cis rs73206853 0.841 rs56324794 chr12:111086449 T/A cg12870014 chr12:110450643 ANKRD13A 0.71 7.52 0.38 5.25e-13 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC cis rs11212617 0.902 rs61913892 chr11:108340216 T/C cg12106634 chr11:108092400 ATM;NPAT 0.41 6.1 0.32 2.99e-9 Response to metformin in type 2 diabetes (glycemic); CRC cis rs1697139 0.935 rs1625369 chr5:66513022 C/T cg11553311 chr5:66541588 NA 0.48 8.12 0.41 9.49e-15 Breast cancer; CRC cis rs1023500 0.551 rs2859438 chr22:42466980 A/T cg11915388 chr22:42470451 FAM109B -0.43 -6.51 -0.34 2.85e-10 Schizophrenia; CRC cis rs9787249 0.957 rs7518431 chr1:40214944 C/T cg19912559 chr1:40204330 PPIE -0.52 -7.66 -0.39 2.03e-13 Blood protein levels; CRC cis rs9747201 0.926 rs34153075 chr17:80135728 C/A cg14673194 chr17:80132900 CCDC57 0.47 6.07 0.32 3.51e-9 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs2228479 0.850 rs76075456 chr16:89834270 T/C cg06558623 chr16:89946397 TCF25 1.13 10.49 0.5 2.13e-22 Skin colour saturation; CRC cis rs11997175 0.546 rs10808337 chr8:33583850 T/C cg04338863 chr8:33670619 NA 0.37 6.16 0.32 2.14e-9 Body mass index; CRC trans rs11098499 0.820 rs12503082 chr4:120284317 A/G cg25214090 chr10:38739885 LOC399744 0.61 9.66 0.47 1.39e-19 Corneal astigmatism; CRC cis rs7264396 0.887 rs1886696 chr20:34055706 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.35 -5.68 -0.3 3.01e-8 Total cholesterol levels; CRC cis rs72627123 0.867 rs74635757 chr14:74489225 C/T cg12022184 chr14:74485813 ENTPD5;C14orf45 0.72 6.19 0.32 1.8e-9 Morning vs. evening chronotype; CRC cis rs62103177 0.810 rs62103194 chr18:77629482 G/A cg12964065 chr18:77638022 KCNG2 0.66 6.69 0.35 9.56e-11 Opioid sensitivity; CRC cis rs2072499 0.966 rs2842864 chr1:156159217 G/A cg24450063 chr1:156163899 SLC25A44 1.15 27.61 0.84 1.1e-87 Testicular germ cell tumor; CRC cis rs11148252 0.538 rs9535880 chr13:52706143 G/A cg00495681 chr13:53174319 NA 0.62 9.32 0.46 1.72e-18 Lewy body disease; CRC cis rs875971 0.929 rs10950041 chr7:65973875 T/C cg18912574 chr7:65842487 NCRNA00174 0.35 6.09 0.32 3.11e-9 Aortic root size; CRC cis rs853679 0.517 rs36078605 chr6:28078032 A/C cg18032046 chr6:28092343 ZSCAN16 -0.52 -6.01 -0.31 4.86e-9 Depression; CRC cis rs4664293 0.669 rs13389096 chr2:160467757 G/A cg08347373 chr2:160653686 CD302 -0.39 -6.55 -0.34 2.16e-10 Monocyte percentage of white cells; CRC cis rs9534288 0.830 rs940 chr13:46627480 C/G cg15192986 chr13:46630673 CPB2 -0.75 -10.84 -0.51 1.27e-23 Blood protein levels; CRC cis rs875971 0.516 rs6945322 chr7:65336056 T/C cg00343986 chr7:65444356 GUSB 0.56 8.47 0.42 8.43e-16 Aortic root size; CRC cis rs9682041 0.877 rs10755126 chr3:170071694 C/G cg11886554 chr3:170076028 SKIL -0.65 -7.86 -0.4 5.5e-14 Glomerular filtration rate in non diabetics (creatinine);Glomerular filtration rate (creatinine); CRC cis rs6089584 0.850 rs6142939 chr20:60627729 A/G cg23262073 chr20:60523788 NA -0.48 -7.57 -0.39 3.7e-13 Body mass index; CRC cis rs2735413 0.881 rs12919672 chr16:78082760 C/G cg04733911 chr16:78082701 NA -0.45 -7.41 -0.38 1.11e-12 Systolic blood pressure (alcohol consumption interaction); CRC cis rs6502050 0.799 rs34448080 chr17:80121275 A/G cg09264619 chr17:80180166 NA -0.35 -5.93 -0.31 7.47e-9 Life satisfaction; CRC cis rs60871478 0.636 rs4719520 chr7:875216 C/G cg13798912 chr7:905769 UNC84A -0.62 -6.82 -0.35 4.29e-11 Cerebrospinal P-tau181p levels; CRC cis rs6964587 1.000 rs7789492 chr7:91668854 C/T cg17063962 chr7:91808500 NA 0.84 14.9 0.63 1.01e-38 Breast cancer; CRC cis rs875971 1.000 rs6958271 chr7:65979331 A/C cg18912574 chr7:65842487 NCRNA00174 0.36 6.16 0.32 2.15e-9 Aortic root size; CRC cis rs911119 0.866 rs6048925 chr20:23579056 C/A cg16589663 chr20:23618590 CST3 0.41 5.74 0.3 2.16e-8 Chronic kidney disease; CRC cis rs7811142 1.000 rs7809801 chr7:100072031 T/C cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.16 17.21 0.69 8.33e-48 Platelet count; CRC cis rs17711722 0.523 rs365896 chr7:65510697 A/G cg00343986 chr7:65444356 GUSB -0.47 -6.88 -0.35 3.09e-11 Calcium levels; CRC cis rs7811142 0.775 rs1636980 chr7:99938864 A/G cg00814883 chr7:100076585 TSC22D4 0.68 8.49 0.42 7.22e-16 Platelet count; CRC cis rs2276314 0.857 rs16967327 chr18:33587036 C/T cg05985134 chr18:33552581 C18orf21 0.46 6.3 0.33 9.7e-10 Endometriosis;Drug-induced torsades de pointes; CRC trans rs3942852 0.568 rs10769312 chr11:48094769 C/T cg15704280 chr7:45808275 SEPT13 0.67 9.4 0.46 9.55e-19 Acute lymphoblastic leukemia (childhood); CRC cis rs10781543 0.763 rs10781539 chr9:139320965 G/A cg14169450 chr9:139327907 INPP5E 0.36 5.65 0.3 3.42e-8 Monocyte percentage of white cells; CRC cis rs6540559 0.673 rs7511996 chr1:210018473 C/A cg22029157 chr1:209979665 IRF6 0.62 7.4 0.38 1.18e-12 Cleft lip with or without cleft palate; CRC cis rs4819052 0.885 rs28576202 chr21:46674684 G/A cg02159808 chr21:46707872 POFUT2;LOC642852 0.53 6.93 0.36 2.17e-11 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs10504229 0.638 rs7826839 chr8:58132075 G/T cg04204079 chr8:58130323 NA -0.45 -5.78 -0.3 1.71e-8 Developmental language disorder (linguistic errors); CRC cis rs10504229 0.906 rs7003285 chr8:58173108 A/G cg02725872 chr8:58115012 NA -0.38 -6.43 -0.33 4.44e-10 Developmental language disorder (linguistic errors); CRC cis rs2239547 0.522 rs2564947 chr3:53046216 C/T cg18404041 chr3:52824283 ITIH1 0.37 7.29 0.37 2.29e-12 Schizophrenia; CRC cis rs524281 0.861 rs3825067 chr11:65878419 A/G cg14036092 chr11:66035641 RAB1B 0.46 5.66 0.3 3.3e-8 Electroencephalogram traits; CRC cis rs11971779 0.680 rs6954547 chr7:139054734 C/T cg07862535 chr7:139043722 LUC7L2 0.57 7.35 0.38 1.61e-12 Diisocyanate-induced asthma; CRC cis rs546131 0.928 rs516228 chr11:34838823 C/T cg24088639 chr11:34937564 PDHX;APIP -0.48 -6.82 -0.35 4.34e-11 Lung disease severity in cystic fibrosis; CRC cis rs6502050 0.765 rs55905076 chr17:80105441 G/A cg09264619 chr17:80180166 NA -0.34 -5.64 -0.3 3.61e-8 Life satisfaction; CRC cis rs7044106 0.762 rs1886337 chr9:123443776 G/C cg09419670 chr9:123605666 PSMD5;LOC253039 0.7 11.47 0.53 7.45e-26 Hip circumference adjusted for BMI; CRC cis rs4660261 0.526 rs2040950 chr1:44315113 G/C cg12908607 chr1:44402522 ARTN -0.52 -9.44 -0.46 7.29e-19 Intelligence (multi-trait analysis); CRC trans rs1814175 0.745 rs7483456 chr11:49774613 C/T cg15704280 chr7:45808275 SEPT13 -1.01 -20.58 -0.75 4.39e-61 Height; CRC cis rs9443645 0.505 rs9359364 chr6:79795992 G/A cg09184832 chr6:79620586 NA -0.44 -7.39 -0.38 1.19e-12 Intelligence (multi-trait analysis); CRC cis rs951366 0.764 rs708725 chr1:205744138 G/T cg14893161 chr1:205819251 PM20D1 0.83 13.48 0.6 2.7e-33 Menarche (age at onset); CRC cis rs9894429 1.000 rs12948099 chr17:79600799 C/G cg21984481 chr17:79567631 NPLOC4 -0.51 -9.6 -0.47 2.19e-19 Eye color traits; CRC cis rs7726839 0.507 rs72703100 chr5:614291 C/T cg16447950 chr5:562315 NA -0.74 -9.73 -0.47 7.89e-20 Obesity-related traits; CRC trans rs34421088 0.576 rs2572432 chr8:11101723 A/G cg06636001 chr8:8085503 FLJ10661 -0.45 -6.23 -0.32 1.42e-9 Neuroticism; CRC cis rs11785400 0.793 rs2976400 chr8:143743611 G/A cg24634471 chr8:143751801 JRK 0.48 6.49 0.34 3.07e-10 Schizophrenia; CRC cis rs11676348 0.755 rs6436026 chr2:218951738 T/A cg00012203 chr2:219082015 ARPC2 -0.42 -6.17 -0.32 2.04e-9 Ulcerative colitis; CRC cis rs9549367 0.762 rs9549694 chr13:113870510 G/A cg18105134 chr13:113819100 PROZ -0.72 -10.79 -0.51 2.01e-23 Platelet distribution width; CRC cis rs853679 0.546 rs200952 chr6:27836976 C/T cg15845792 chr6:28175446 NA 0.73 6.16 0.32 2.08e-9 Depression; CRC cis rs2153535 0.526 rs7748404 chr6:8472500 A/T cg21535247 chr6:8435926 SLC35B3 0.5 7.53 0.38 4.89e-13 Motion sickness; CRC cis rs34172651 0.517 rs874484 chr16:24803242 T/C cg06505273 chr16:24850292 NA 0.47 5.69 0.3 2.77e-8 Intelligence (multi-trait analysis); CRC cis rs2204008 0.837 rs11612125 chr12:38213212 C/T cg13010199 chr12:38710504 ALG10B 0.45 5.74 0.3 2.1e-8 Bladder cancer; CRC cis rs10924970 0.967 rs10925270 chr1:235425875 C/T cg26050004 chr1:235667680 B3GALNT2 0.39 5.76 0.3 1.93e-8 Asthma; CRC cis rs7412746 0.611 rs6660084 chr1:150748803 T/C cg15448220 chr1:150897856 SETDB1 0.51 7.19 0.37 4.25e-12 Melanoma; CRC cis rs4731207 0.698 rs34600520 chr7:124490938 T/C cg23710748 chr7:124431027 NA -0.38 -6.08 -0.32 3.42e-9 Cutaneous malignant melanoma; CRC cis rs10504229 0.683 rs55660024 chr8:58128943 G/A cg04204079 chr8:58130323 NA -0.45 -5.78 -0.3 1.71e-8 Developmental language disorder (linguistic errors); CRC cis rs2354432 0.556 rs2353984 chr1:146813358 C/T cg25205988 chr1:146714368 CHD1L 1.14 9.9 0.48 2.19e-20 Mitochondrial DNA levels; CRC trans rs3780486 0.757 rs10121987 chr9:33119818 A/G cg04842962 chr6:43655489 MRPS18A 1.13 24.82 0.81 2.21e-77 IgG glycosylation; CRC cis rs1862618 0.627 rs744023 chr5:56197078 C/T cg20203395 chr5:56204925 C5orf35 -0.8 -8.73 -0.43 1.34e-16 Initial pursuit acceleration; CRC cis rs2243480 1.000 rs13220979 chr7:65363204 G/A cg18252515 chr7:66147081 NA -1.13 -13.15 -0.59 4.8e-32 Diabetic kidney disease; CRC cis rs4969178 0.832 rs4969185 chr17:76398157 G/C cg05887092 chr17:76393375 PGS1 0.55 9.88 0.48 2.46e-20 HDL cholesterol levels; CRC cis rs838147 0.508 rs507766 chr19:49208543 T/C cg21064579 chr19:49206444 FUT2 0.47 8.26 0.41 3.51e-15 Dietary macronutrient intake; CRC cis rs1018836 0.608 rs6992512 chr8:91477936 C/A cg16814680 chr8:91681699 NA -0.58 -8.65 -0.43 2.25e-16 Ejection fraction in Tripanosoma cruzi seropositivity; CRC cis rs225245 0.817 rs2301730 chr17:33998683 A/G cg05299278 chr17:33885742 SLFN14 0.49 8.09 0.41 1.2e-14 Reticulocyte count;Reticulocyte fraction of red cells;High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells; CRC trans rs7267979 1.000 rs1888998 chr20:25291826 A/G cg17903999 chr18:56338584 MALT1 0.43 7.01 0.36 1.36e-11 Liver enzyme levels (alkaline phosphatase); CRC cis rs2976388 0.507 rs2572874 chr8:143837219 C/T cg20041105 chr8:143859282 LYNX1 0.55 9.87 0.48 2.7e-20 Urinary tract infection frequency; CRC cis rs28386778 0.863 rs1376110 chr17:61779927 A/C cg25654072 chr17:61904446 PSMC5;FTSJ3 0.72 10.71 0.51 3.68e-23 Prudent dietary pattern; CRC trans rs916888 0.773 rs199535 chr17:44822662 A/G cg13957321 chr17:43675089 NA 0.49 6.18 0.32 1.94e-9 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC trans rs4841097 0.806 rs6992247 chr8:8948469 G/T cg16141378 chr3:129829833 LOC729375 -0.46 -6.56 -0.34 2.12e-10 Platelet distribution width; CRC cis rs7618915 0.571 rs6778844 chr3:52596398 C/T cg07507251 chr3:52567010 NT5DC2 -0.49 -7.06 -0.36 9.91e-12 Bipolar disorder; CRC cis rs2898681 0.519 rs6848200 chr4:53730181 A/G cg00791764 chr4:53727839 RASL11B 0.51 6.9 0.36 2.73e-11 Optic nerve measurement (cup area); CRC cis rs950169 1.000 rs35297609 chr15:84772896 A/G cg03959625 chr15:84868606 LOC388152 0.42 6.33 0.33 8.21e-10 Schizophrenia; CRC cis rs2072499 1.000 rs2241108 chr1:156181007 C/G cg24450063 chr1:156163899 SLC25A44 1.14 27.71 0.84 4.8e-88 Testicular germ cell tumor; CRC cis rs9549328 0.670 rs2993344 chr13:113617022 C/T cg08614441 chr13:113633676 MCF2L 0.4 7.12 0.37 6.64e-12 Systolic blood pressure; CRC cis rs12580194 0.593 rs7314118 chr12:55737403 A/C cg19537932 chr12:55886519 OR6C68 -0.66 -8.5 -0.42 6.6e-16 Cancer; CRC cis rs57221529 0.563 rs4957057 chr5:569230 C/G cg09021430 chr5:549028 NA -0.86 -11.13 -0.52 1.25e-24 Lung disease severity in cystic fibrosis; CRC cis rs796364 0.906 rs6740981 chr2:201060216 T/C cg25936922 chr2:200820526 C2orf60;C2orf47 0.56 6.26 0.33 1.22e-9 Schizophrenia; CRC cis rs6570726 0.818 rs412350 chr6:145852409 T/C cg05347473 chr6:146136440 FBXO30 0.39 6.11 0.32 2.82e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs354033 1.000 rs11766910 chr7:149279620 C/T cg24335155 chr7:149193227 ZNF746 0.36 5.63 0.3 3.93e-8 Multiple sclerosis; CRC cis rs6951245 0.935 rs79143504 chr7:1110212 A/G cg20603222 chr7:1096387 C7orf50;GPR146 -0.7 -8.01 -0.4 1.96e-14 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs921968 0.643 rs678218 chr2:219379709 C/A cg02176678 chr2:219576539 TTLL4 0.49 8.05 0.41 1.58e-14 Mean corpuscular hemoglobin concentration; CRC cis rs7208859 0.673 rs17826219 chr17:29161845 G/A cg14008862 chr17:28927542 LRRC37B2 0.55 5.8 0.3 1.56e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs7647973 1.000 rs11130190 chr3:49402137 T/C cg20833759 chr3:49053208 WDR6;DALRD3 0.55 8.2 0.41 5.38e-15 Menarche (age at onset); CRC cis rs9640161 0.659 rs59572505 chr7:150014986 C/T cg12556325 chr7:150026731 C7orf29;LRRC61 -0.43 -6.39 -0.33 5.73e-10 Blood protein levels;Circulating chemerin levels; CRC cis rs7123876 0.553 rs10898868 chr11:72431679 A/G cg04827223 chr11:72435913 ARAP1 -0.39 -5.62 -0.3 4.1e-8 Body mass index; CRC cis rs2228479 0.850 rs17233448 chr16:89816424 G/T cg06558623 chr16:89946397 TCF25 1.15 10.8 0.51 1.85e-23 Skin colour saturation; CRC cis rs9903692 0.954 rs9909933 chr17:46280232 G/T cg21215337 chr17:46176117 CBX1 0.43 7.83 0.4 6.68e-14 Pulse pressure; CRC cis rs11148252 0.538 rs9535885 chr13:52726524 A/G cg00495681 chr13:53174319 NA 0.64 9.57 0.47 2.75e-19 Lewy body disease; CRC cis rs10504229 0.554 rs17802082 chr8:58095867 C/T cg22535103 chr8:58192502 C8orf71 -0.58 -6.95 -0.36 1.94e-11 Developmental language disorder (linguistic errors); CRC cis rs800160 0.582 rs2521286 chr11:2341971 G/A cg09785033 chr11:2336066 TSPAN32 -0.46 -5.64 -0.3 3.74e-8 Bacteremia; CRC cis rs6674176 0.561 rs12127226 chr1:44395309 C/T cg12908607 chr1:44402522 ARTN -0.6 -10.98 -0.52 4.06e-24 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Cognitive ability; CRC cis rs7259376 0.869 rs6511346 chr19:22537574 T/C cg02657401 chr19:22469223 NA -0.32 -6.8 -0.35 4.8e-11 Menopause (age at onset); CRC cis rs12682352 0.602 rs4841044 chr8:8664940 A/G cg06636001 chr8:8085503 FLJ10661 -0.55 -8.42 -0.42 1.14e-15 Neuroticism; CRC cis rs7618915 0.547 rs13064064 chr3:52657002 T/C cg15147215 chr3:52552868 STAB1 -0.62 -10.22 -0.49 1.76e-21 Bipolar disorder; CRC cis rs4555082 0.830 rs2735812 chr14:105727575 A/G cg13114125 chr14:105738426 BRF1 -0.8 -11.68 -0.54 1.36e-26 Mean platelet volume;Platelet distribution width; CRC cis rs11971779 0.680 rs10261557 chr7:139099037 G/C cg23387468 chr7:139079360 LUC7L2 0.41 7.05 0.36 1.04e-11 Diisocyanate-induced asthma; CRC cis rs9359856 0.673 rs1179901 chr6:90321196 C/T cg13799429 chr6:90582589 CASP8AP2 -0.61 -8.15 -0.41 7.53e-15 Bipolar disorder; CRC cis rs7618501 0.521 rs3796386 chr3:49899795 G/A cg05623727 chr3:50126028 RBM5 0.58 9.81 0.48 4.43e-20 Intelligence (multi-trait analysis); CRC trans rs916888 0.821 rs199514 chr17:44856881 G/A cg23590916 chr17:43697445 MGC57346 -0.57 -6.03 -0.32 4.4e-9 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs514406 0.584 rs12095247 chr1:53193796 A/C cg27535305 chr1:53392650 SCP2 0.34 6.1 0.32 2.9e-9 Monocyte count; CRC cis rs10982256 0.967 rs10982246 chr9:117250393 A/G cg13636371 chr9:117264095 DFNB31 0.38 7.32 0.37 1.88e-12 Bipolar disorder; CRC trans rs1455244 0.700 rs7229302 chr18:11508904 G/T cg06019692 chr13:20207818 MPHOSPH8 0.38 6.01 0.31 4.97e-9 Schizophrenia; CRC cis rs10751667 0.666 rs7103585 chr11:971166 T/C cg06064525 chr11:970664 AP2A2 -0.3 -6.11 -0.32 2.78e-9 Alzheimer's disease (late onset); CRC cis rs1801251 1.000 rs283480 chr2:233648742 G/A cg25237894 chr2:233734115 C2orf82 0.57 9.23 0.45 3.51e-18 Coronary artery disease; CRC cis rs9837602 0.507 rs793452 chr3:99529523 C/T cg08350549 chr3:99591722 C3orf26;FILIP1L;MIR548G 0.38 5.91 0.31 8.77e-9 Breast cancer; CRC cis rs9814567 0.722 rs13083717 chr3:134348796 G/A cg06109529 chr3:134205091 CEP63;ANAPC13 0.62 7.51 0.38 5.51e-13 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs1881797 0.932 rs2387038 chr1:247674919 G/A cg11166453 chr1:247681781 NA 0.44 6.95 0.36 1.94e-11 Acute lymphoblastic leukemia (childhood); CRC cis rs6502050 0.835 rs34960918 chr17:80113925 A/G cg13198984 chr17:80129470 CCDC57 0.46 8.16 0.41 6.94e-15 Life satisfaction; CRC cis rs7618915 0.501 rs13085775 chr3:52678370 C/T cg08222913 chr3:52553049 STAB1 -0.33 -6.24 -0.33 1.35e-9 Bipolar disorder; CRC cis rs11690935 0.959 rs11897196 chr2:172585595 G/A cg13550731 chr2:172543902 DYNC1I2 -1.1 -18.58 -0.72 3.5e-53 Schizophrenia; CRC cis rs73001065 0.551 rs10424702 chr19:19508013 A/G cg03709012 chr19:19516395 GATAD2A 0.84 7.29 0.37 2.3e-12 LDL cholesterol; CRC cis rs7312774 0.618 rs12316286 chr12:107343020 C/A cg16260113 chr12:107380972 MTERFD3 0.79 8.09 0.41 1.18e-14 Severe influenza A (H1N1) infection; CRC cis rs3858526 0.834 rs7128847 chr11:6003111 C/T cg02574844 chr11:5959923 NA -0.43 -5.75 -0.3 2.05e-8 DNA methylation (variation); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg04402966 chr7:87505783 SLC25A40;DBF4 0.4 6.24 0.33 1.36e-9 Response to antipsychotic treatment; CRC cis rs8062405 0.964 rs7193733 chr16:28875482 A/G cg08761264 chr16:28874980 SH2B1 -0.44 -5.83 -0.31 1.33e-8 Cognitive ability (multi-trait analysis);Cognitive ability; CRC cis rs12580194 0.593 rs12578879 chr12:55797773 C/T cg19537932 chr12:55886519 OR6C68 -0.72 -9.09 -0.45 9.43e-18 Cancer; CRC cis rs2011503 1.000 rs6511029 chr19:19471419 G/T cg11584989 chr19:19387371 SF4 -0.52 -6.0 -0.31 5.07e-9 Bipolar disorder; CRC cis rs561341 1.000 rs68140514 chr17:30335781 T/C cg12193833 chr17:30244370 NA -0.64 -8.13 -0.41 8.94e-15 Hip circumference adjusted for BMI; CRC cis rs854765 0.505 rs4924832 chr17:17897739 A/G cg23957660 chr17:17878224 LRRC48 0.38 6.83 0.35 4.2e-11 Total body bone mineral density; CRC cis rs11122272 0.735 rs2790897 chr1:231491712 C/A cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.56 -8.34 -0.42 2.12e-15 Hemoglobin concentration; CRC cis rs7539542 0.556 rs6686801 chr1:202874730 C/T cg19681188 chr1:202830198 LOC148709 0.47 6.8 0.35 4.94e-11 Mean platelet volume; CRC trans rs8002861 0.935 rs4942256 chr13:44455920 A/T cg17145862 chr1:211918768 LPGAT1 0.79 16.07 0.66 2.57e-43 Leprosy; CRC cis rs12887734 0.524 rs4906363 chr14:104210239 G/A cg01849466 chr14:104193079 ZFYVE21 -0.44 -6.65 -0.34 1.21e-10 Schizophrenia;Autism spectrum disorder or schizophrenia; CRC cis rs4423214 0.765 rs2002064 chr11:71163420 A/G cg05163923 chr11:71159392 DHCR7 -0.67 -8.04 -0.41 1.67e-14 Vitamin D levels; CRC cis rs3018066 0.867 rs6843331 chr4:106958304 C/T cg01869342 chr4:106983673 TBCK 0.42 6.43 0.33 4.38e-10 Cancer; CRC cis rs763121 0.853 rs5757166 chr22:38995385 G/T cg06544989 chr22:39130855 UNC84B 0.46 7.41 0.38 1.08e-12 Menopause (age at onset); CRC cis rs8014204 0.836 rs11159099 chr14:75235397 A/G cg03030879 chr14:75389066 RPS6KL1 -0.5 -8.03 -0.4 1.76e-14 Caffeine consumption; CRC cis rs1577917 0.917 rs1414201 chr6:86500316 G/A cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.53 -6.93 -0.36 2.27e-11 Response to antipsychotic treatment; CRC cis rs875971 0.545 rs801199 chr7:66025273 A/G cg11764359 chr7:65958608 NA -0.45 -5.78 -0.3 1.77e-8 Aortic root size; CRC cis rs9733 0.596 rs6678013 chr1:150623285 T/G cg17724175 chr1:150552817 MCL1 0.58 9.4 0.46 9.25e-19 Tonsillectomy; CRC cis rs3956705 0.933 rs13311772 chr7:32999810 C/T cg05721444 chr7:32995514 FKBP9 -0.5 -7.2 -0.37 4.01e-12 Red cell distribution width; CRC trans rs7267979 0.966 rs3002698 chr20:25303379 C/G cg17903999 chr18:56338584 MALT1 0.44 7.16 0.37 5.3e-12 Liver enzyme levels (alkaline phosphatase); CRC trans rs2048656 0.635 rs7830613 chr8:9649769 A/G cg06636001 chr8:8085503 FLJ10661 -0.49 -6.89 -0.36 2.88e-11 Schizophrenia; CRC cis rs4642101 0.640 rs9877049 chr3:12821231 A/G cg24848339 chr3:12840334 CAND2 0.36 6.81 0.35 4.64e-11 QRS complex (12-leadsum); CRC cis rs6088590 0.561 rs6059934 chr20:33178324 G/T cg24642439 chr20:33292090 TP53INP2 0.42 7.07 0.36 9.21e-12 Coronary artery disease; CRC cis rs9372498 0.536 rs10484286 chr6:118956447 T/C cg24463073 chr6:118973353 C6orf204 0.51 6.47 0.34 3.56e-10 Diastolic blood pressure; CRC cis rs172166 0.694 rs203876 chr6:28046673 T/C cg25164649 chr6:28176230 NA 0.6 8.64 0.43 2.5e-16 Cardiac Troponin-T levels; CRC cis rs6831352 0.918 rs17218560 chr4:100060794 C/T cg13256891 chr4:100009986 ADH5 0.65 8.83 0.44 6.42e-17 Alcohol dependence; CRC cis rs10791323 0.581 rs2723608 chr11:133710149 A/G cg03690763 chr11:133734501 NA -0.35 -5.87 -0.31 1.07e-8 Childhood ear infection; CRC cis rs3785574 0.962 rs2584632 chr17:61880641 G/A cg25654072 chr17:61904446 PSMC5;FTSJ3 0.43 6.06 0.32 3.71e-9 Height; CRC trans rs6076960 0.652 rs3852945 chr20:6254118 T/C cg17788362 chr6:86352627 SYNCRIP 0.49 6.86 0.35 3.47e-11 Smooth-surface caries; CRC cis rs13191362 1.000 rs13215491 chr6:163010325 T/C cg21926612 chr6:163149169 PACRG;PARK2 0.78 10.8 0.51 1.77e-23 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs11148252 0.904 rs9526927 chr13:53051627 C/T cg02158880 chr13:53174818 NA 0.48 7.25 0.37 3.07e-12 Lewy body disease; CRC cis rs6700896 0.931 rs12042807 chr1:66134052 T/C cg04111102 chr1:66153794 NA 0.35 6.1 0.32 3.03e-9 C-reactive protein;Mean corpuscular volume;Mean corpuscular hemoglobin; CRC cis rs28386778 0.897 rs2727326 chr17:61923016 G/A cg25654072 chr17:61904446 PSMC5;FTSJ3 0.7 10.94 0.52 5.62e-24 Prudent dietary pattern; CRC cis rs7503807 0.935 rs62068348 chr17:78608575 T/C cg09596252 chr17:78655493 RPTOR 0.4 6.26 0.33 1.23e-9 Obesity; CRC cis rs6840360 0.642 rs2724568 chr4:152352223 C/G cg09659197 chr4:152720779 NA 0.34 6.73 0.35 7.72e-11 Intelligence (multi-trait analysis); CRC cis rs6580649 1.000 rs10783227 chr12:48400617 C/T cg05342945 chr12:48394962 COL2A1 -0.43 -6.03 -0.32 4.36e-9 Lung cancer; CRC cis rs116095464 0.681 rs9687745 chr5:229309 C/T cg22496380 chr5:211416 CCDC127 -0.86 -10.04 -0.48 7.52e-21 Breast cancer; CRC cis rs2108225 0.714 rs10953548 chr7:107436232 G/A cg18560240 chr7:107437656 SLC26A3 -0.6 -9.02 -0.45 1.61e-17 Ulcerative colitis; CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg06665941 chr21:34602869 IFNAR2 -0.52 -6.34 -0.33 7.52e-10 Diisocyanate-induced asthma; CRC cis rs7680126 0.596 rs4697714 chr4:10143786 A/T cg00071950 chr4:10020882 SLC2A9 -0.48 -6.25 -0.33 1.29e-9 Urate levels in lean individuals;Urate levels in overweight individuals;Urate levels in obese individuals; CRC cis rs910316 0.763 rs13712 chr14:75483812 T/C cg08847533 chr14:75593920 NEK9 0.85 15.05 0.64 2.58e-39 Height; CRC cis rs9814567 0.752 rs1534029 chr3:134330213 C/G cg06109529 chr3:134205091 CEP63;ANAPC13 -0.67 -9.6 -0.47 2.04e-19 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs2421770 0.530 rs3901811 chr11:35365675 C/T cg13971030 chr11:35366721 SLC1A2 -0.38 -6.67 -0.35 1.08e-10 Staphylococcus aureus nasal carriage (persistent); CRC cis rs3820068 0.581 rs72645861 chr1:15920314 A/G cg27534772 chr1:16042836 PLEKHM2 0.53 10.04 0.48 7.27e-21 Systolic blood pressure; CRC cis rs7666738 0.830 rs11097606 chr4:99011486 C/T cg17366294 chr4:99064904 C4orf37 0.44 7.35 0.38 1.54e-12 Colonoscopy-negative controls vs population controls; CRC cis rs7584330 0.826 rs72620825 chr2:238381243 G/A cg16989719 chr2:238392110 NA -0.45 -7.54 -0.38 4.75e-13 Prostate cancer; CRC cis rs6740322 1.000 rs4128209 chr2:43554729 G/C cg06169590 chr2:43455088 ZFP36L2;LOC100129726 -0.54 -6.85 -0.35 3.73e-11 Coronary artery disease; CRC cis rs823143 0.570 rs1361754 chr1:205801872 C/T cg07157834 chr1:205819609 PM20D1 -0.58 -8.92 -0.44 3.3e-17 Monocyte percentage of white cells; CRC cis rs1799949 0.965 rs2236762 chr17:41226675 A/T cg19454999 chr17:41278357 BRCA1;NBR2 0.4 6.12 0.32 2.66e-9 Menopause (age at onset); CRC cis rs3733585 0.805 rs882222 chr4:9981294 G/A cg00071950 chr4:10020882 SLC2A9 0.64 11.86 0.55 3.03e-27 Cleft plate (environmental tobacco smoke interaction); CRC cis rs950169 1.000 rs35648189 chr15:84740748 T/C cg11189052 chr15:85197271 WDR73 0.61 8.81 0.44 7.07e-17 Schizophrenia; CRC cis rs9611565 0.512 rs5751147 chr22:42139054 G/A cg06481639 chr22:41940642 POLR3H 0.56 6.21 0.32 1.59e-9 Vitiligo; CRC cis rs9372498 0.572 rs10484289 chr6:118827836 T/C cg18833306 chr6:118973337 C6orf204 0.44 5.82 0.31 1.38e-8 Diastolic blood pressure; CRC cis rs11148252 0.669 rs4884320 chr13:53006914 T/C cg12458913 chr13:53173898 NA 0.49 7.01 0.36 1.36e-11 Lewy body disease; CRC cis rs7043114 0.544 rs12335553 chr9:95297871 A/C cg13798575 chr9:95087839 CENPP;NOL8 -0.39 -5.71 -0.3 2.47e-8 Height; CRC cis rs9549260 0.577 rs6563841 chr13:41239178 A/C cg21288729 chr13:41239152 FOXO1 0.5 7.78 0.39 9.23e-14 Red blood cell count; CRC cis rs8077889 0.917 rs28694735 chr17:41912144 A/G cg16892393 chr17:41919603 NA 0.51 7.48 0.38 7.03e-13 Triglycerides; CRC cis rs10540 0.686 rs12421266 chr11:537120 C/T cg03934478 chr11:495069 RNH1 0.67 7.36 0.38 1.45e-12 Body mass index; CRC cis rs9814567 0.778 rs4955546 chr3:134334738 G/A cg06109529 chr3:134205091 CEP63;ANAPC13 -0.68 -9.77 -0.47 5.83e-20 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs7811142 1.000 rs60257855 chr7:100026780 G/C cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.62 7.99 0.4 2.22e-14 Platelet count; CRC cis rs4481887 0.708 rs6696691 chr1:248539720 T/C cg00666640 chr1:248458726 OR2T12 0.4 7.35 0.38 1.56e-12 Common traits (Other); CRC cis rs514406 0.861 rs7513052 chr1:53241360 C/T cg08859206 chr1:53392774 SCP2 0.43 6.9 0.36 2.7e-11 Monocyte count; CRC cis rs7177699 0.534 rs4387568 chr15:79109514 C/G cg15571903 chr15:79123663 NA -0.31 -6.0 -0.31 5.06e-9 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; CRC cis rs2479724 0.901 rs33954419 chr6:41786136 A/G cg17623882 chr6:41773611 USP49 -0.57 -9.84 -0.48 3.33e-20 Menarche (age at onset); CRC cis rs6456156 0.755 rs4710182 chr6:167514061 G/A cg07513332 chr6:167530253 CCR6 0.38 6.25 0.33 1.27e-9 Primary biliary cholangitis; CRC cis rs561341 1.000 rs4795667 chr17:30244443 T/C cg23018236 chr17:30244563 NA -0.64 -7.84 -0.4 6.23e-14 Hip circumference adjusted for BMI; CRC cis rs1577917 0.958 rs11755642 chr6:86450066 A/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.63 -8.0 -0.4 2.15e-14 Response to antipsychotic treatment; CRC trans rs629535 0.547 rs62513420 chr8:70122597 G/A cg21567404 chr3:27674614 NA -0.92 -13.28 -0.59 1.63e-32 Dupuytren's disease; CRC cis rs7725052 0.609 rs10065527 chr5:40456628 G/A cg09067459 chr5:40385259 NA -0.4 -6.68 -0.35 9.91e-11 Pediatric autoimmune diseases; CRC cis rs79976124 0.800 rs10944857 chr6:66637078 C/T cg07460842 chr6:66804631 NA 0.7 8.78 0.44 9.05e-17 Type 2 diabetes; CRC cis rs3785574 0.962 rs35448669 chr17:61938923 G/A cg23090583 chr17:61904693 PSMC5;FTSJ3 0.63 8.95 0.44 2.62e-17 Height; CRC cis rs7617773 0.817 rs4131361 chr3:48328812 T/C cg11946769 chr3:48343235 NME6 0.64 8.85 0.44 5.61e-17 Coronary artery disease; CRC cis rs951366 0.617 rs9438393 chr1:205782718 A/G cg23034840 chr1:205782522 SLC41A1 0.57 8.07 0.41 1.32e-14 Menarche (age at onset); CRC cis rs990171 0.955 rs4070554 chr2:103074493 A/G cg03938978 chr2:103052716 IL18RAP 0.46 5.87 0.31 1.09e-8 Lymphocyte counts; CRC cis rs10751667 0.643 rs7396046 chr11:937176 T/C ch.11.42038R chr11:967971 AP2A2 0.58 9.85 0.48 3.1e-20 Alzheimer's disease (late onset); CRC cis rs9322193 1.000 rs9322193 chr6:149919143 T/G cg05861140 chr6:150128134 PCMT1 -0.41 -6.67 -0.34 1.11e-10 Lung cancer; CRC cis rs172166 0.694 rs203876 chr6:28046673 T/C cg26587870 chr6:27730563 NA -0.38 -5.86 -0.31 1.1e-8 Cardiac Troponin-T levels; CRC cis rs889312 0.500 rs252905 chr5:56118875 C/T cg03609598 chr5:56110824 MAP3K1 -0.45 -6.34 -0.33 7.54e-10 Breast cancer;Breast cancer (early onset); CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg07610776 chr16:1832675 SPSB3;NUBP2 0.47 5.99 0.31 5.47e-9 Thyroid stimulating hormone; CRC cis rs7940866 0.838 rs1991898 chr11:130801786 C/G cg12179176 chr11:130786555 SNX19 -0.6 -8.94 -0.44 2.79e-17 Schizophrenia; CRC cis rs1983891 1.000 rs9381080 chr6:41527698 G/C cg20194872 chr6:41519635 FOXP4 0.4 5.75 0.3 2.04e-8 Prostate cancer; CRC cis rs4423214 0.840 rs1792234 chr11:71182018 T/C cg13043300 chr11:71146211 DHCR7 -0.43 -5.79 -0.3 1.67e-8 Vitamin D levels; CRC cis rs9486719 0.895 rs3734238 chr6:96996228 A/T cg06623918 chr6:96969491 KIAA0776 -0.82 -9.56 -0.47 2.8e-19 Migraine;Coronary artery disease; CRC cis rs8180040 0.845 rs295441 chr3:47333295 T/A cg02527881 chr3:46936655 PTH1R -0.4 -7.49 -0.38 6.52e-13 Colorectal cancer; CRC cis rs8180040 0.739 rs11719306 chr3:47184182 G/A cg10298567 chr3:47292165 KIF9 -0.39 -6.38 -0.33 6.13e-10 Colorectal cancer; CRC cis rs9911578 0.817 rs304264 chr17:56749628 A/G cg12560992 chr17:57184187 TRIM37 0.84 14.97 0.64 5.48e-39 Intelligence (multi-trait analysis); CRC cis rs765787 0.530 rs2668737 chr15:45522799 C/T cg24006582 chr15:45444508 DUOX1 -0.56 -8.42 -0.42 1.2e-15 Uric acid levels; CRC cis rs290268 0.669 rs10448310 chr9:93556174 A/G cg02608019 chr9:93564028 SYK 0.43 6.7 0.35 9.19e-11 Platelet count; CRC cis rs3741404 0.560 rs2875748 chr11:63915537 G/A cg05555928 chr11:63887634 MACROD1 0.37 6.05 0.32 3.99e-9 Platelet count; CRC cis rs473651 0.904 rs501333 chr2:239336045 G/A cg21699342 chr2:239360505 ASB1 0.58 10.43 0.5 3.43e-22 Multiple system atrophy; CRC cis rs6554196 0.932 rs3819387 chr4:55527065 C/T cg18836493 chr4:55524333 KIT 0.34 5.92 0.31 8.3e-9 Monocyte count; CRC cis rs66887589 0.934 rs7681980 chr4:120533223 G/A cg09307838 chr4:120376055 NA -0.51 -7.81 -0.4 7.86e-14 Diastolic blood pressure; CRC cis rs2576037 0.523 rs1539881 chr18:44477897 C/T cg19077165 chr18:44547161 KATNAL2 -0.67 -11.64 -0.54 1.9e-26 Personality dimensions; CRC cis rs17362650 0.694 rs10929582 chr2:9585200 C/G cg23886495 chr2:9695866 ADAM17 0.44 5.71 0.3 2.55e-8 Alcohol dependence (age at onset); CRC cis rs7264396 0.887 rs4911503 chr20:34063095 C/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.38 -6.2 -0.32 1.68e-9 Total cholesterol levels; CRC cis rs3849570 1.000 rs2290081 chr3:81810725 C/T cg07356753 chr3:81810745 GBE1 -0.74 -11.14 -0.52 1.16e-24 Waist circumference;Body mass index; CRC cis rs1129187 0.755 rs9462855 chr6:42925936 G/C cg02353165 chr6:42928485 GNMT 0.72 12.23 0.56 1.37e-28 Alzheimer's disease in APOE e4+ carriers; CRC cis rs7666738 0.830 rs1365458 chr4:98950961 C/T cg03676636 chr4:99064102 C4orf37 0.19 5.68 0.3 3.04e-8 Colonoscopy-negative controls vs population controls; CRC cis rs9517320 0.517 rs4772097 chr13:99194652 C/A cg20487152 chr13:99095054 FARP1 -0.44 -6.29 -0.33 1e-9 Longevity; CRC cis rs12802200 0.561 rs746708 chr11:572129 C/T cg01842473 chr11:617407 IRF7;MUPCDH -0.5 -6.57 -0.34 2e-10 Systemic lupus erythematosus; CRC cis rs7904985 1.000 rs11201991 chr10:88117122 T/C cg07322936 chr10:88137208 NA -0.47 -6.27 -0.33 1.15e-9 Barrett's esophagus; CRC cis rs7618915 0.547 rs2590846 chr3:52692359 C/G cg10802521 chr3:52805072 NEK4 -0.58 -9.01 -0.44 1.77e-17 Bipolar disorder; CRC cis rs7827545 1.000 rs1372660 chr8:135566788 C/G cg13086574 chr8:135490821 ZFAT -0.37 -6.26 -0.33 1.19e-9 Hypertension (SNP x SNP interaction); CRC cis rs972578 0.837 rs2092211 chr22:43318765 G/T cg01576275 chr22:43409880 NA -0.38 -5.88 -0.31 1.01e-8 Mean platelet volume; CRC trans rs116095464 0.558 rs7731089 chr5:290422 A/C cg00938859 chr5:1591904 SDHAP3 0.71 7.58 0.39 3.45e-13 Breast cancer; CRC cis rs1348850 0.632 rs13008833 chr2:178514439 G/C cg02961200 chr2:178257176 LOC100130691;AGPS 0.64 9.04 0.45 1.39e-17 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs1552244 1.000 rs7651058 chr3:10066964 C/T cg13047869 chr3:10149882 C3orf24 0.5 6.91 0.36 2.51e-11 Alzheimer's disease; CRC cis rs765787 0.530 rs1706834 chr15:45517854 G/A cg24006582 chr15:45444508 DUOX1 -0.53 -8.23 -0.41 4.38e-15 Uric acid levels; CRC cis rs826838 0.900 rs9739128 chr12:38948960 A/T cg26384229 chr12:38710491 ALG10B 0.73 10.25 0.49 1.37e-21 Heart rate; CRC cis rs3106136 0.967 rs11722476 chr4:95170839 G/A cg11021082 chr4:95130006 SMARCAD1 -0.46 -7.17 -0.37 4.89e-12 Capecitabine sensitivity; CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg07058086 chr8:29120186 KIF13B 0.38 6.23 0.32 1.42e-9 Obesity-related traits; CRC cis rs12580194 0.593 rs74844018 chr12:55766871 G/A cg19537932 chr12:55886519 OR6C68 -0.73 -9.2 -0.45 4.32e-18 Cancer; CRC cis rs4604732 0.588 rs12045675 chr1:247623915 C/A cg12758973 chr1:247694275 LOC148824;OR2C3 0.43 6.43 0.33 4.61e-10 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CRC trans rs35110281 0.720 rs162374 chr21:44927089 T/C cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO -0.49 -8.08 -0.41 1.23e-14 Mean corpuscular volume; CRC cis rs4713118 0.513 rs149945 chr6:28002853 T/C cg25164649 chr6:28176230 NA 0.61 8.98 0.44 2.21e-17 Parkinson's disease; CRC cis rs654950 1.000 rs646228 chr1:41986066 A/C cg06885757 chr1:42089581 HIVEP3 0.45 7.53 0.38 4.87e-13 Airway imaging phenotypes; CRC cis rs13191362 1.000 rs34177053 chr6:163007772 T/C cg06582575 chr6:163149167 PACRG;PARK2 0.71 10.22 0.49 1.72e-21 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs9916302 0.904 rs2168785 chr17:37407135 C/T cg15445000 chr17:37608096 MED1 0.42 9.19 0.45 4.43e-18 Glomerular filtration rate (creatinine); CRC cis rs7927771 1.000 rs34128973 chr11:47851376 C/T cg18512352 chr11:47633146 NA -0.48 -9.4 -0.46 9.71e-19 Subjective well-being; CRC cis rs3857536 0.740 rs9354390 chr6:66890162 C/T cg07460842 chr6:66804631 NA 0.43 5.76 0.3 1.93e-8 Blood trace element (Cu levels); CRC cis rs9648716 1.000 rs6464037 chr7:140456064 A/T cg10747023 chr7:140774559 NA -0.44 -5.72 -0.3 2.39e-8 Type 2 diabetes; CRC cis rs16852403 0.517 rs11584886 chr1:178243362 G/A cg00404053 chr1:178313656 RASAL2 0.48 6.12 0.32 2.7e-9 Childhood ear infection; CRC cis rs8078723 0.677 rs11658328 chr17:38149236 T/C cg17467752 chr17:38218738 THRA -0.57 -9.13 -0.45 6.89e-18 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); CRC cis rs7739232 0.764 rs75874790 chr6:53521241 A/C cg15658676 chr6:53530538 KLHL31 -0.67 -5.66 -0.3 3.32e-8 Hip circumference adjusted for BMI; CRC cis rs3768617 0.510 rs3768629 chr1:183074582 T/C ch.1.3577855R chr1:183094577 LAMC1 0.86 15.25 0.64 4.14e-40 Fuchs's corneal dystrophy; CRC cis rs9911578 0.934 rs58092632 chr17:57111101 T/C cg12560992 chr17:57184187 TRIM37 -0.95 -17.85 -0.7 2.63e-50 Intelligence (multi-trait analysis); CRC cis rs875971 0.964 rs697969 chr7:65558478 C/A cg12463550 chr7:65579703 CRCP -0.49 -7.05 -0.36 1.08e-11 Aortic root size; CRC cis rs2839186 0.814 rs12482209 chr21:47664275 C/G cg11766577 chr21:47581405 C21orf56 0.48 7.72 0.39 1.38e-13 Testicular germ cell tumor; CRC cis rs7918232 0.662 rs10764662 chr10:27300643 T/A cg14240646 chr10:27532245 ACBD5 -0.64 -7.1 -0.36 7.8e-12 Breast cancer; CRC cis rs67478160 0.634 rs2368559 chr14:104230535 C/T cg08213375 chr14:104286397 PPP1R13B 0.59 12.05 0.55 5.96e-28 Schizophrenia; CRC cis rs875971 0.862 rs1167408 chr7:65556108 G/A cg00343986 chr7:65444356 GUSB -0.44 -6.31 -0.33 9.16e-10 Aortic root size; CRC cis rs4665809 0.549 rs3828255 chr2:26413252 G/A cg22920501 chr2:26401640 FAM59B 0.83 10.49 0.5 2.19e-22 Gut microbiome composition (summer); CRC cis rs6502050 0.835 rs4789738 chr17:80123053 G/A cg09264619 chr17:80180166 NA -0.35 -5.93 -0.31 7.47e-9 Life satisfaction; CRC cis rs4660214 0.666 rs11205828 chr1:39719346 C/T cg11070191 chr1:39582205 MACF1 0.37 5.81 0.31 1.45e-8 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs79387448 0.745 rs1523196 chr2:103163700 T/G cg09003973 chr2:102972529 NA 0.73 8.01 0.4 1.97e-14 Gut microbiota (bacterial taxa); CRC cis rs17270561 0.609 rs4711101 chr6:25741970 A/G cg17691542 chr6:26056736 HIST1H1C 0.72 9.24 0.45 3.07e-18 Iron status biomarkers; CRC cis rs7953249 0.935 rs7135337 chr12:121404155 A/C cg02403541 chr12:121454288 C12orf43 -0.39 -5.89 -0.31 9.55e-9 Invasive epithelial ovarian cancer;High-grade serous ovarian cancer;Chronic obstructive pulmonary disease-related biomarkers;N-glycan levels;Serous invasive ovarian cancer;Epithelial ovarian cancer; CRC cis rs10493773 0.609 rs2389972 chr1:86190666 A/G cg17807903 chr1:86174739 ZNHIT6 -0.61 -16.72 -0.68 7.33e-46 Urate levels in overweight individuals; CRC cis rs7705042 0.865 rs4912804 chr5:141493614 T/C cg07392085 chr5:141489673 NDFIP1 0.47 7.46 0.38 7.85e-13 Asthma; CRC cis rs6541297 1.000 rs2144298 chr1:230280198 T/C cg20703242 chr1:230279135 GALNT2 0.52 7.7 0.39 1.58e-13 Coronary artery disease; CRC cis rs6500395 0.962 rs7199625 chr16:48650217 G/C cg04672837 chr16:48644449 N4BP1 0.41 5.82 0.31 1.42e-8 Response to tocilizumab in rheumatoid arthritis; CRC cis rs4974559 0.739 rs10032327 chr4:1323537 C/T cg02980000 chr4:1222292 CTBP1 0.78 8.39 0.42 1.44e-15 Systolic blood pressure; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg03389848 chr2:187350541 ZC3H15 0.38 6.35 0.33 7.01e-10 Liver disease severity in Alagille syndrome; CRC cis rs56146971 0.714 rs55709253 chr14:91853363 T/C cg16433844 chr14:91963127 SMEK1 -0.52 -6.15 -0.32 2.26e-9 Alzheimer disease and age of onset; CRC cis rs10779751 1.000 rs10779751 chr1:11284336 A/G cg08854313 chr1:11322531 MTOR 0.66 9.38 0.46 1.13e-18 Body mass index; CRC cis rs6938 0.575 rs12902515 chr15:75160998 G/C cg09165964 chr15:75287851 SCAMP5 0.55 8.77 0.44 9.47e-17 Breast cancer; CRC cis rs614226 0.935 rs2235222 chr12:120892193 G/C cg27489772 chr12:121021490 NA -0.49 -6.71 -0.35 8.69e-11 Type 1 diabetes nephropathy; CRC cis rs798766 1.000 rs2236786 chr4:1719294 T/C cg05874882 chr4:1763078 NA 0.4 6.86 0.35 3.35e-11 Bladder cancer;Urinary bladder cancer; CRC cis rs2976388 0.556 rs4736321 chr8:143822194 C/T cg24046110 chr8:143859143 LYNX1 -0.42 -6.45 -0.33 4.08e-10 Urinary tract infection frequency; CRC trans rs6550704 0.687 rs9865314 chr3:22634337 A/G cg15555727 chr8:144692268 PYCRL -0.42 -6.34 -0.33 7.58e-10 Daytime sleep phenotypes; CRC trans rs2228479 0.850 rs62052660 chr16:89847420 T/A cg21302420 chr1:112162376 RAP1A 0.72 5.96 0.31 6.33e-9 Skin colour saturation; CRC cis rs79349575 0.749 rs318093 chr17:46989354 A/G cg22482690 chr17:47019901 SNF8 0.48 8.06 0.41 1.48e-14 Type 2 diabetes; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg19455953 chr2:207630073 FASTKD2;MDH1B 0.5 6.67 0.35 1.09e-10 Thyroid stimulating hormone; CRC trans rs1814175 0.616 rs847641 chr11:49919261 T/C cg03929089 chr4:120376271 NA -0.91 -16.01 -0.66 4.58e-43 Height; CRC cis rs6662572 0.737 rs72677545 chr1:46571221 C/T cg03123370 chr1:45965343 CCDC163P;MMACHC 0.49 6.38 0.33 6.09e-10 Blood protein levels; CRC cis rs7647973 0.626 rs62262672 chr3:49655927 T/A cg03060546 chr3:49711283 APEH -0.63 -6.98 -0.36 1.62e-11 Menarche (age at onset); CRC cis rs7647973 0.626 rs11709734 chr3:49745235 G/A cg13072238 chr3:49761600 GMPPB -0.48 -5.68 -0.3 2.89e-8 Menarche (age at onset); CRC cis rs7617773 0.780 rs7632297 chr3:48348163 A/C cg11946769 chr3:48343235 NME6 0.73 9.71 0.47 9.45e-20 Coronary artery disease; CRC cis rs10540 0.908 rs12792111 chr11:520921 G/C cg08200582 chr11:442649 ANO9 -0.71 -7.3 -0.37 2.19e-12 Body mass index; CRC cis rs7107174 0.892 rs12284390 chr11:78103902 C/A cg02023728 chr11:77925099 USP35 0.47 7.25 0.37 2.92e-12 Testicular germ cell tumor; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg13478957 chr1:153700146 INTS3 0.44 6.09 0.32 3.17e-9 Response to antipsychotic treatment; CRC cis rs7249142 0.549 rs2238667 chr19:19282523 G/A cg19540702 chr19:19281175 LOC729991-MEF2B;MEF2B -0.38 -5.61 -0.3 4.21e-8 IgG glycosylation; CRC cis rs4713118 0.869 rs6930992 chr6:27712120 A/C cg21251018 chr6:28226885 NKAPL 0.38 5.71 0.3 2.5e-8 Parkinson's disease; CRC cis rs8020095 0.571 rs723432 chr14:67379015 A/C cg00791868 chr14:66963628 C14orf53 0.49 6.59 0.34 1.8e-10 Depression (quantitative trait); CRC cis rs2857891 1.000 rs2595500 chr11:6963165 C/T cg14883916 chr11:6947541 ZNF215 -0.61 -7.07 -0.36 9.62e-12 Response to cytadine analogues (cytosine arabinoside); CRC cis rs9420 0.961 rs11604333 chr11:57467035 C/G cg23127183 chr11:57508653 C11orf31 -0.52 -7.04 -0.36 1.12e-11 Schizophrenia; CRC cis rs7772486 0.641 rs9390374 chr6:146368175 A/T cg23711669 chr6:146136114 FBXO30 0.58 8.59 0.43 3.46e-16 Lobe attachment (rater-scored or self-reported); CRC cis rs4423214 1.000 rs7944926 chr11:71165625 A/G cg05163923 chr11:71159392 DHCR7 0.67 9.51 0.46 4.2e-19 Vitamin D levels; CRC cis rs9303280 0.773 rs11078925 chr17:38025208 T/C cg00129232 chr17:37814104 STARD3 -0.46 -7.25 -0.37 2.96e-12 Self-reported allergy; CRC cis rs7945705 0.846 rs4929911 chr11:8816495 T/C cg14711859 chr11:8959438 ASCL3 -0.35 -5.74 -0.3 2.2e-8 Hemoglobin concentration; CRC cis rs780096 0.506 rs8395 chr2:27715207 T/A cg02592271 chr2:27665507 KRTCAP3 -0.26 -5.82 -0.31 1.43e-8 Total body bone mineral density; CRC trans rs75804782 0.641 rs55740938 chr2:239332647 G/A cg01134436 chr17:81009848 B3GNTL1 0.79 7.42 0.38 9.91e-13 Morning vs. evening chronotype;Chronotype; CRC trans rs12599106 0.648 rs12447240 chr16:34928236 C/T cg21548813 chr6:291882 DUSP22 0.67 9.71 0.47 9.1e-20 Menopause (age at onset); CRC cis rs6951245 0.872 rs75280240 chr7:1058511 C/T cg21664854 chr7:1097933 C7orf50;GPR146 0.77 8.81 0.44 7.6e-17 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs7618915 0.547 rs11714419 chr3:52628816 A/G cg15147215 chr3:52552868 STAB1 -0.63 -10.26 -0.49 1.28e-21 Bipolar disorder; CRC cis rs7215564 0.908 rs35884143 chr17:78656043 A/G cg09596252 chr17:78655493 RPTOR 0.54 5.7 0.3 2.7e-8 Myopia (pathological); CRC cis rs7945718 0.621 rs61879826 chr11:12684486 T/C cg25843174 chr11:12811716 TEAD1 0.39 7.17 0.37 4.89e-12 Educational attainment (years of education); CRC cis rs9807989 0.524 rs7594402 chr2:103021267 A/T cg03938978 chr2:103052716 IL18RAP 0.59 10.17 0.49 2.54e-21 Asthma; CRC cis rs7772486 0.846 rs866473 chr6:146353414 A/C cg23711669 chr6:146136114 FBXO30 0.67 11.57 0.54 3.42e-26 Lobe attachment (rater-scored or self-reported); CRC cis rs2180341 0.842 rs9375492 chr6:127545492 C/T cg27446573 chr6:127587934 RNF146 -0.87 -11.15 -0.52 1.02e-24 Breast cancer; CRC cis rs17023223 0.537 rs10923767 chr1:119732347 C/T cg05756136 chr1:119680316 WARS2 -0.52 -6.99 -0.36 1.57e-11 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for BMI in active individuals; CRC cis rs3800461 0.544 rs41312309 chr6:34498328 C/T cg17674042 chr6:34482479 PACSIN1 -0.92 -9.2 -0.45 4.09e-18 Chronic lymphocytic leukemia; CRC cis rs7932354 0.583 rs7940578 chr11:46812227 A/G cg19486271 chr11:47235900 DDB2 -0.42 -6.42 -0.33 4.9e-10 Bone mineral density (hip);Bone mineral density; CRC cis rs501120 0.584 rs1615053 chr10:44677935 T/C cg09554077 chr10:44749378 NA 0.68 7.34 0.38 1.65e-12 Coronary artery disease;Coronary heart disease; CRC cis rs6694672 0.557 rs6671696 chr1:197083196 T/C cg13682187 chr1:196946512 CFHR5 0.46 7.36 0.38 1.52e-12 Asthma; CRC cis rs514406 0.929 rs2607095 chr1:53325639 T/C cg24675658 chr1:53192096 ZYG11B -0.57 -8.48 -0.42 7.78e-16 Monocyte count; CRC cis rs853679 0.517 rs9348793 chr6:28084189 G/A cg02631126 chr6:28058918 ZSCAN12L1 0.29 5.87 0.31 1.05e-8 Depression; CRC cis rs514406 0.679 rs541852 chr1:53256834 A/G cg08859206 chr1:53392774 SCP2 0.63 10.08 0.49 5.32e-21 Monocyte count; CRC cis rs921968 0.541 rs562510 chr2:219443001 A/C cg02176678 chr2:219576539 TTLL4 0.53 8.43 0.42 1.08e-15 Mean corpuscular hemoglobin concentration; CRC cis rs3858526 0.523 rs10769287 chr11:5884845 T/C cg02574844 chr11:5959923 NA -0.51 -7.64 -0.39 2.32e-13 DNA methylation (variation); CRC cis rs561341 1.000 rs757009 chr17:30243937 A/G cg23018236 chr17:30244563 NA -0.47 -6.55 -0.34 2.21e-10 Hip circumference adjusted for BMI; CRC cis rs2153535 0.580 rs4451187 chr6:8473910 C/T cg07606381 chr6:8435919 SLC35B3 0.68 10.85 0.51 1.17e-23 Motion sickness; CRC trans rs45509595 0.749 rs401763 chr6:27782528 T/C cg16898833 chr6:26189333 HIST1H4D 0.72 6.46 0.34 3.84e-10 Breast cancer; CRC cis rs8077889 0.917 rs72836547 chr17:41902799 G/T cg25876840 chr17:41920477 NA 0.61 8.6 0.43 3.23e-16 Triglycerides; CRC cis rs1949733 1.000 rs3103071 chr4:8508579 C/G cg11789530 chr4:8429930 ACOX3 -0.85 -12.66 -0.57 3.4e-30 Response to antineoplastic agents; CRC cis rs12477438 0.834 rs10179043 chr2:99687490 T/C cg14399236 chr2:99771627 LIPT1;TSGA10 -0.72 -10.1 -0.49 4.6e-21 Chronic sinus infection; CRC cis rs12594515 0.967 rs11857628 chr15:45998206 C/T cg06207120 chr15:45996521 NA 0.3 7.25 0.37 3e-12 Waist circumference;Weight; CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg16025584 chr9:139887217 C9orf142 -0.57 -7.1 -0.36 7.6e-12 Diisocyanate-induced asthma; CRC cis rs10946940 0.864 rs13201411 chr6:27498217 G/C cg08798685 chr6:27730294 NA 0.38 5.71 0.3 2.59e-8 Systemic lupus erythematosus; CRC cis rs56283067 0.847 rs10456118 chr6:44692825 G/T cg18551225 chr6:44695536 NA -0.41 -5.95 -0.31 6.68e-9 Total body bone mineral density; CRC cis rs7120118 0.517 rs61896015 chr11:47279928 C/A cg25783544 chr11:47291846 MADD 0.64 5.77 0.3 1.85e-8 HDL cholesterol; CRC cis rs4665809 0.590 rs2303892 chr2:26461733 C/G cg22920501 chr2:26401640 FAM59B 0.85 12.21 0.56 1.54e-28 Gut microbiome composition (summer); CRC cis rs7945705 0.747 rs2568020 chr11:8994715 C/T cg00186954 chr11:8933980 ST5;C11orf17 -0.46 -7.78 -0.39 9.52e-14 Hemoglobin concentration; CRC cis rs57221529 0.713 rs12522724 chr5:590742 T/C cg09021430 chr5:549028 NA -0.7 -7.75 -0.39 1.17e-13 Lung disease severity in cystic fibrosis; CRC cis rs854765 0.624 rs9899634 chr17:17727943 A/T cg04398451 chr17:18023971 MYO15A 0.47 7.89 0.4 4.54e-14 Total body bone mineral density; CRC cis rs7725052 0.609 rs6870757 chr5:40452107 C/T cg09067459 chr5:40385259 NA 0.38 6.33 0.33 8.18e-10 Pediatric autoimmune diseases; CRC cis rs35146811 0.586 rs6964754 chr7:99589404 G/A cg03265037 chr7:99691720 MIR25;MCM7;MIR106B;MIR93 0.43 5.76 0.3 1.92e-8 Coronary artery disease; CRC cis rs6952808 0.630 rs4719443 chr7:2161099 A/G cg00106254 chr7:1943704 MAD1L1 -0.4 -5.61 -0.3 4.23e-8 Bipolar disorder and schizophrenia; CRC cis rs13191362 0.507 rs13207363 chr6:163201285 C/G cg21926612 chr6:163149169 PACRG;PARK2 -0.54 -8.45 -0.42 9.38e-16 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs10504229 0.595 rs36081958 chr8:58117505 C/G cg02725872 chr8:58115012 NA -0.65 -11.45 -0.53 8.72e-26 Developmental language disorder (linguistic errors); CRC cis rs2576037 0.501 rs7227700 chr18:44537102 T/G cg23996704 chr18:44553084 KATNAL2 -0.38 -7.62 -0.39 2.68e-13 Personality dimensions; CRC cis rs11190604 0.943 rs113791644 chr10:102324330 T/G cg16342193 chr10:102329863 NA -0.37 -5.97 -0.31 6.08e-9 Palmitoleic acid (16:1n-7) levels; CRC cis rs7208859 0.623 rs9914242 chr17:29216245 G/T cg14008862 chr17:28927542 LRRC37B2 0.58 5.76 0.3 1.97e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs7811142 1.000 rs7794485 chr7:100068936 T/C cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.99 12.88 0.58 5.07e-31 Platelet count; CRC cis rs9469913 0.668 rs112563428 chr6:34800435 C/T cg14254433 chr6:34482411 PACSIN1 -0.64 -6.22 -0.32 1.48e-9 Body mass index (joint analysis main effects and physical activity interaction);Body mass index;Body mass index in physically active individuals; CRC cis rs35146811 0.538 rs3823642 chr7:99796072 T/C cg13334819 chr7:99746414 C7orf59 -0.52 -6.82 -0.35 4.39e-11 Coronary artery disease; CRC cis rs6594535 0.516 rs7731407 chr5:111101027 G/T cg06838283 chr5:111090142 C5orf13 0.39 6.14 0.32 2.43e-9 Chickenpox; CRC cis rs9462027 0.606 rs2814981 chr6:34581055 G/A cg07306190 chr6:34760872 UHRF1BP1 -0.35 -6.16 -0.32 2.08e-9 Systemic lupus erythematosus; CRC cis rs950169 0.580 rs36126054 chr15:85177723 T/G cg17507749 chr15:85114479 UBE2QP1 0.65 9.29 0.46 2.15e-18 Schizophrenia; CRC trans rs7395662 0.500 rs10838984 chr11:48640485 C/T cg21153622 chr11:89784906 NA -0.52 -8.58 -0.43 3.8e-16 HDL cholesterol; CRC cis rs6499255 1.000 rs11075733 chr16:69773435 G/T cg15192750 chr16:69999425 NA 0.55 7.29 0.37 2.29e-12 IgE levels; CRC cis rs2952156 0.684 rs931992 chr17:37821435 G/T cg07936489 chr17:37558343 FBXL20 -0.5 -7.37 -0.38 1.39e-12 Asthma; CRC cis rs801193 0.569 rs2659892 chr7:66200305 A/G cg18876405 chr7:65276391 NA 0.51 8.29 0.42 3.02e-15 Aortic root size; CRC cis rs11785693 0.862 rs17435612 chr8:4987896 C/T cg26367366 chr8:4980734 NA -0.72 -9.28 -0.46 2.28e-18 Neuroticism (multi-trait analysis);Neuroticism; CRC cis rs909002 0.800 rs3753613 chr1:32082000 C/T cg01639898 chr1:32083012 HCRTR1 -0.28 -5.72 -0.3 2.34e-8 Intelligence (multi-trait analysis); CRC cis rs7727544 0.904 rs6897575 chr5:131604535 C/T cg09877947 chr5:131593287 PDLIM4 0.36 6.82 0.35 4.47e-11 Blood metabolite levels; CRC cis rs62045849 0.557 rs9938463 chr16:89183772 A/G cg08015503 chr16:89190385 ACSF3 -0.94 -7.38 -0.38 1.32e-12 Red blood cell count; CRC cis rs9398803 0.865 rs9401882 chr6:126755055 A/G cg19875578 chr6:126661172 C6orf173 0.42 5.82 0.31 1.43e-8 Male-pattern baldness; CRC cis rs11098499 0.644 rs34835603 chr4:120553428 C/T cg24375607 chr4:120327624 NA 0.48 7.54 0.38 4.62e-13 Corneal astigmatism; CRC cis rs9372498 0.536 rs9489409 chr6:118802721 A/G cg01339444 chr6:118972232 C6orf204 0.53 5.97 0.31 6.07e-9 Diastolic blood pressure; CRC cis rs929596 0.501 rs4530361 chr2:234590041 A/G cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.42 -6.32 -0.33 8.45e-10 Total bilirubin levels in HIV-1 infection; CRC cis rs7246967 0.611 rs2194113 chr19:22958075 C/T cg08271804 chr19:22816896 ZNF492 0.38 5.85 0.31 1.2e-8 Bronchopulmonary dysplasia; CRC cis rs9733 0.596 rs17606613 chr1:150683015 C/T cg10589385 chr1:150898437 SETDB1 0.28 5.96 0.31 6.66e-9 Tonsillectomy; CRC cis rs7772486 0.875 rs7766595 chr6:146364507 A/T cg05347473 chr6:146136440 FBXO30 0.37 5.89 0.31 9.38e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs3858526 0.959 rs11039723 chr11:5956002 G/C cg02574844 chr11:5959923 NA -0.48 -6.62 -0.34 1.44e-10 DNA methylation (variation); CRC cis rs12681287 0.640 rs13264364 chr8:87466385 G/T cg27223183 chr8:87520930 FAM82B -0.52 -7.44 -0.38 8.7e-13 Caudate activity during reward; CRC cis rs7173389 1.000 rs8038766 chr15:73663314 A/G cg01796676 chr15:73680284 NA 0.52 7.12 0.37 6.76e-12 Resting heart rate; CRC cis rs832540 0.898 rs331498 chr5:56249842 C/G cg12311346 chr5:56204834 C5orf35 0.5 7.61 0.39 2.88e-13 Coronary artery disease; CRC cis rs3087591 0.920 rs4795592 chr17:29612620 C/G cg24425628 chr17:29625626 OMG;NF1 -0.85 -16.63 -0.68 1.68e-45 Hip circumference; CRC cis rs7666738 0.830 rs13139024 chr4:99020700 C/T cg17366294 chr4:99064904 C4orf37 0.43 7.29 0.37 2.28e-12 Colonoscopy-negative controls vs population controls; CRC cis rs3996993 0.809 rs4715326 chr6:52657552 C/T cg20803780 chr6:52668592 GSTA1 -0.38 -7.17 -0.37 5.05e-12 Hemoglobin concentration; CRC trans rs9858542 0.953 rs34588335 chr3:49407660 G/C cg21582582 chr3:182698605 DCUN1D1 -0.52 -6.61 -0.34 1.52e-10 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs7309 0.935 rs11884495 chr2:162059969 A/T cg22496339 chr2:162101262 NA 0.78 13.1 0.59 7.99e-32 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Educational attainment; CRC cis rs6840360 0.904 rs73862064 chr4:152503100 T/A cg09659197 chr4:152720779 NA 0.38 7.54 0.38 4.63e-13 Intelligence (multi-trait analysis); CRC cis rs16921914 0.559 rs2985140 chr11:31315886 C/T cg14844989 chr11:31128820 NA 0.35 6.19 0.32 1.79e-9 Bone mineral density (spine); CRC cis rs34891900 0.507 rs2587084 chr22:18140644 T/G cg19898043 chr22:18121309 BCL2L13 0.5 7.61 0.39 2.84e-13 Sum neutrophil eosinophil counts; CRC cis rs2811415 0.628 rs13067034 chr3:127750310 C/T cg13719885 chr3:127795394 NA -0.37 -5.67 -0.3 3.19e-8 Lung function (FEV1/FVC); CRC cis rs2739330 0.828 rs4820572 chr22:24250355 T/C cg11060661 chr22:24314208 DDT;DDTL 0.5 8.4 0.42 1.36e-15 Liver enzyme levels (gamma-glutamyl transferase); CRC trans rs3749237 0.964 rs11714957 chr3:49776178 C/T cg21665057 chr3:196295764 WDR53;FBXO45 0.56 7.87 0.4 5.15e-14 Resting heart rate; CRC cis rs6089584 0.888 rs6061979 chr20:60617141 C/G cg06108461 chr20:60628389 TAF4 -0.92 -15.92 -0.66 1.01e-42 Body mass index; CRC cis rs11758351 1.000 rs77961951 chr6:26186075 A/G cg10723962 chr6:26240782 HIST1H4F -0.41 -5.97 -0.31 6.07e-9 Gout;Renal underexcretion gout; CRC cis rs10206020 0.921 rs72776302 chr2:1571383 G/A cg12573674 chr2:1569213 NA -0.82 -10.94 -0.52 5.91e-24 IgG glycosylation; CRC trans rs875971 0.660 rs2191268 chr7:66110224 C/T ch.11.967412F chr11:46784048 SNORD67;CKAP5 -0.38 -6.04 -0.32 4.15e-9 Aortic root size; CRC cis rs514406 0.929 rs554301 chr1:53321948 A/T cg25767906 chr1:53392781 SCP2 0.44 7.3 0.37 2.14e-12 Monocyte count; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg20701983 chr7:135194361 CNOT4 -0.42 -6.18 -0.32 1.87e-9 Myopia (pathological); CRC trans rs11098499 0.954 rs10518331 chr4:120323595 C/T cg25214090 chr10:38739885 LOC399744 0.66 10.47 0.5 2.41e-22 Corneal astigmatism; CRC cis rs35306767 0.953 rs1539174 chr10:974870 C/G cg20503657 chr10:835505 NA 0.77 9.68 0.47 1.12e-19 Eosinophil percentage of granulocytes; CRC cis rs875971 0.862 rs6460282 chr7:65691246 T/C cg00343986 chr7:65444356 GUSB -0.47 -6.48 -0.34 3.41e-10 Aortic root size; CRC cis rs4423214 0.840 rs1792233 chr11:71182179 G/A cg05163923 chr11:71159392 DHCR7 -0.63 -7.59 -0.39 3.28e-13 Vitamin D levels; CRC cis rs68170813 0.559 rs1548523 chr7:106944408 G/A cg02696742 chr7:106810147 HBP1 -0.59 -6.66 -0.34 1.18e-10 Coronary artery disease; CRC cis rs6952808 0.698 rs11765639 chr7:1986738 G/A cg04267008 chr7:1944627 MAD1L1 -0.73 -9.7 -0.47 9.69e-20 Bipolar disorder and schizophrenia; CRC cis rs6504950 0.695 rs9904377 chr17:52985982 C/T cg26251398 chr17:52985966 TOM1L1 0.43 6.55 0.34 2.27e-10 Breast cancer; CRC cis rs7107174 1.000 rs10899470 chr11:78020052 C/T cg02023728 chr11:77925099 USP35 0.54 7.6 0.39 3.18e-13 Testicular germ cell tumor; CRC cis rs172166 0.516 rs1225710 chr6:28100640 C/T cg10876282 chr6:28092338 ZSCAN16 -0.42 -5.91 -0.31 8.48e-9 Cardiac Troponin-T levels; CRC cis rs11098499 0.562 rs2389879 chr4:120557684 G/A cg09307838 chr4:120376055 NA -0.6 -9.25 -0.45 2.87e-18 Corneal astigmatism; CRC cis rs6988636 1.000 rs59601467 chr8:124193488 C/T cg27053337 chr8:124217698 FAM83A 0.42 6.36 0.33 6.62e-10 Urinary uromodulin levels; CRC cis rs2075371 1.000 rs2598291 chr7:133988313 C/G cg11752832 chr7:134001865 SLC35B4 0.51 7.84 0.4 6.37e-14 Mean platelet volume; CRC cis rs561341 1.000 rs4795668 chr17:30244554 G/A cg00745463 chr17:30367425 LRRC37B -0.79 -8.82 -0.44 6.94e-17 Hip circumference adjusted for BMI; CRC cis rs1007738 0.580 rs10501319 chr11:47174062 C/T cg19486271 chr11:47235900 DDB2 0.42 5.76 0.3 1.92e-8 Bone mineral density (hip); CRC cis rs6860806 0.507 rs2631364 chr5:131706914 C/G cg18301423 chr5:131593218 PDLIM4 -0.39 -6.48 -0.34 3.33e-10 Breast cancer; CRC cis rs9910055 0.659 rs7214540 chr17:42256604 A/G cg09913183 chr17:42254507 C17orf65;ASB16 0.65 10.2 0.49 2.05e-21 Total body bone mineral density; CRC cis rs62158211 1.000 rs62158211 chr2:114106139 G/T cg17784749 chr2:114082611 LOC440839 0.55 6.35 0.33 7.18e-10 Sleep duration (oversleepers vs undersleepers);Sleep traits (multi-trait analysis);Sleep duration; CRC cis rs2075371 1.000 rs1862050 chr7:133980999 T/C cg02659138 chr7:134003124 SLC35B4 0.37 6.38 0.33 5.99e-10 Mean platelet volume; CRC cis rs2370759 0.945 rs74625866 chr10:32597618 A/T cg01819863 chr10:32635814 EPC1 1.09 12.79 0.58 1.12e-30 Sexual dysfunction (female); CRC cis rs9868809 0.881 rs2276852 chr3:48666923 A/G cg00383909 chr3:49044727 WDR6 0.59 6.45 0.34 3.9e-10 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; CRC cis rs561341 1.000 rs113115092 chr17:30284164 G/A cg23018236 chr17:30244563 NA -0.65 -7.78 -0.39 9.41e-14 Hip circumference adjusted for BMI; CRC cis rs449789 0.524 rs4709306 chr6:159775930 G/A cg14500486 chr6:159655392 FNDC1 -0.45 -6.77 -0.35 6.08e-11 Pulse pressure; CRC cis rs4964805 0.913 rs11111795 chr12:104204830 C/A cg02344784 chr12:104178138 NT5DC3 0.54 8.18 0.41 6.05e-15 Attention deficit hyperactivity disorder; CRC cis rs7122539 0.646 rs6591222 chr11:66551143 C/T cg24851651 chr11:66362959 CCS 0.41 6.78 0.35 5.58e-11 HIV-1 susceptibility; CRC cis rs1215050 0.776 rs1627946 chr4:98844416 G/A cg05340658 chr4:99064831 C4orf37 -0.48 -7.08 -0.36 8.54e-12 Waist-to-hip ratio adjusted for body mass index; CRC cis rs9522267 0.535 rs11069898 chr13:112231512 C/T cg10483660 chr13:112241077 NA -0.47 -8.7 -0.43 1.62e-16 Hepatitis; CRC cis rs4819052 0.800 rs4819045 chr21:46660138 C/A cg11663144 chr21:46675770 NA -0.83 -14.12 -0.61 9.88e-36 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs3091242 0.934 rs666686 chr1:25719511 A/G cg27572855 chr1:25598939 RHD 0.36 6.5 0.34 3.04e-10 Erythrocyte sedimentation rate; CRC trans rs7179994 0.579 rs72712679 chr15:28301730 C/T cg05237436 chr5:138533428 SIL1 0.71 6.29 0.33 1.03e-9 Shingles; CRC cis rs172166 0.561 rs149976 chr6:27987776 C/T cg03623178 chr6:28175578 NA -0.66 -9.89 -0.48 2.36e-20 Cardiac Troponin-T levels; CRC cis rs4853012 0.838 rs4452177 chr2:74345206 A/G cg05890377 chr2:74357713 NA 0.57 9.2 0.45 4.18e-18 Gestational age at birth (maternal effect); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg15112458 chr7:104654695 MLL5;LOC100216545 0.39 6.34 0.33 7.39e-10 Liver disease severity in Alagille syndrome; CRC cis rs10504229 0.683 rs16921829 chr8:58110950 A/G cg02725872 chr8:58115012 NA -0.66 -11.74 -0.54 8.39e-27 Developmental language disorder (linguistic errors); CRC cis rs13118159 0.550 rs4974612 chr4:1364543 A/G cg02475777 chr4:1388615 CRIPAK 0.51 6.45 0.34 3.99e-10 Longevity; CRC cis rs1124376 1.000 rs6774367 chr3:20163077 G/A cg05072819 chr3:20081367 KAT2B 0.46 5.74 0.3 2.2e-8 Bipolar disorder and schizophrenia; CRC cis rs6546550 0.803 rs10165883 chr2:70117015 C/T cg02498382 chr2:70120550 SNRNP27 -0.55 -9.26 -0.45 2.79e-18 Prevalent atrial fibrillation; CRC cis rs11212617 0.967 rs7127490 chr11:108286758 T/C cg01991180 chr11:108092276 ATM;NPAT 0.41 5.93 0.31 7.71e-9 Response to metformin in type 2 diabetes (glycemic); CRC cis rs10504229 0.610 rs7011877 chr8:58147181 C/T cg21724239 chr8:58056113 NA 0.42 6.13 0.32 2.46e-9 Developmental language disorder (linguistic errors); CRC cis rs8177253 0.763 rs12769 chr3:133474328 G/A cg24879335 chr3:133465180 TF 0.32 5.77 0.3 1.86e-8 Iron status biomarkers; CRC cis rs6665290 0.904 rs11587443 chr1:227187896 T/C cg10327440 chr1:227177885 CDC42BPA -1.04 -23.31 -0.79 1.24e-71 Myeloid white cell count; CRC cis rs17401966 0.522 rs10864450 chr1:10333959 G/T cg19773385 chr1:10388646 KIF1B -0.47 -7.33 -0.37 1.83e-12 Hepatocellular carcinoma; CRC trans rs587242 1.000 rs12727152 chr1:96915548 G/A cg10631902 chr5:14652156 NA 0.44 6.9 0.36 2.62e-11 Body mass index (joint analysis main effects and physical activity interaction);Body mass index in physically inactive individuals;Body mass index; CRC cis rs7635838 0.586 rs379241 chr3:11291565 G/A cg00170343 chr3:11313890 ATG7 0.58 8.96 0.44 2.48e-17 HDL cholesterol; CRC cis rs9322193 0.923 rs10782316 chr6:150073891 A/C cg05861140 chr6:150128134 PCMT1 -0.39 -6.26 -0.33 1.21e-9 Lung cancer; CRC cis rs17209837 1.000 rs45447097 chr7:87086144 G/A cg00919237 chr7:87102261 ABCB4 -0.5 -6.1 -0.32 3.03e-9 Gallbladder cancer; CRC trans rs11148252 0.634 rs4941727 chr13:52721067 A/G cg18335740 chr13:41363409 SLC25A15 -0.45 -6.75 -0.35 6.73e-11 Lewy body disease; CRC cis rs3771570 0.786 rs62186378 chr2:242211554 G/A cg21155796 chr2:242212141 HDLBP 0.63 6.88 0.35 2.95e-11 Prostate cancer; CRC cis rs6089584 0.854 rs6061985 chr20:60622362 T/C cg13770153 chr20:60521292 NA -0.58 -8.73 -0.43 1.3e-16 Body mass index; CRC cis rs6860806 0.507 rs272880 chr5:131670178 C/T cg24060327 chr5:131705240 SLC22A5 -0.52 -7.78 -0.39 9.63e-14 Breast cancer; CRC cis rs734999 0.545 rs4074789 chr1:2537464 A/G cg20673091 chr1:2541236 MMEL1 0.36 5.86 0.31 1.13e-8 Ulcerative colitis; CRC cis rs7811142 1.000 rs67239991 chr7:100046504 A/G cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.91 12.61 0.57 5.01e-30 Platelet count; CRC cis rs10504229 0.593 rs16921589 chr8:58024387 C/A cg02290350 chr8:58132656 NA -0.46 -5.84 -0.31 1.24e-8 Developmental language disorder (linguistic errors); CRC cis rs1048238 0.846 rs945419 chr1:16344858 C/T cg24140574 chr1:16342155 HSPB7 0.42 6.05 0.32 3.86e-9 Systolic blood pressure; CRC trans rs9929218 0.871 rs1862748 chr16:68832943 C/T cg04657470 chr2:198365150 HSPE1;HSPD1 -0.79 -11.5 -0.54 5.99e-26 Colorectal cancer; CRC cis rs2033711 0.783 rs11671113 chr19:58958087 C/T cg00825309 chr19:58991885 ZNF446 -0.47 -6.88 -0.35 2.97e-11 Uric acid clearance; CRC cis rs4319547 0.915 rs10734924 chr12:123018894 T/G cg05707623 chr12:122985044 ZCCHC8 -0.78 -9.72 -0.47 8.54e-20 Body mass index; CRC cis rs6860806 0.507 rs200837 chr5:131699958 G/A cg18758796 chr5:131593413 PDLIM4 0.4 6.43 0.33 4.39e-10 Breast cancer; CRC cis rs4665809 0.531 rs12987980 chr2:26462093 A/T cg25036284 chr2:26402008 FAM59B 0.62 7.86 0.4 5.64e-14 Gut microbiome composition (summer); CRC cis rs6988636 1.000 rs13260626 chr8:124190317 C/T cg27053337 chr8:124217698 FAM83A 0.43 6.59 0.34 1.74e-10 Urinary uromodulin levels; CRC cis rs9359856 0.956 rs6912680 chr6:90300010 T/G cg13799429 chr6:90582589 CASP8AP2 0.47 6.61 0.34 1.55e-10 Bipolar disorder; CRC cis rs8180040 0.620 rs7373821 chr3:47080127 A/C cg27129171 chr3:47204927 SETD2 0.73 11.53 0.54 4.47e-26 Colorectal cancer; CRC trans rs853679 0.760 rs9468317 chr6:28198456 A/G cg06606381 chr12:133084897 FBRSL1 -0.57 -6.08 -0.32 3.38e-9 Depression; CRC cis rs6585424 1.000 rs10466228 chr10:81924373 A/G cg11900509 chr10:81946545 ANXA11 -0.68 -8.54 -0.43 4.9e-16 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs6662572 0.737 rs7512448 chr1:46449291 A/G cg03123370 chr1:45965343 CCDC163P;MMACHC -0.44 -5.7 -0.3 2.71e-8 Blood protein levels; CRC cis rs977987 0.806 rs12449170 chr16:75463012 C/T cg03315344 chr16:75512273 CHST6 0.55 9.25 0.45 3.01e-18 Dupuytren's disease; CRC trans rs1814175 0.817 rs12295885 chr11:50036762 T/G cg03929089 chr4:120376271 NA -0.93 -17.98 -0.7 7.84e-51 Height; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg09341209 chr11:2422446 TSSC4 0.39 5.98 0.31 5.93e-9 Intelligence (multi-trait analysis); CRC cis rs1545257 0.537 rs3108793 chr2:24648138 A/C cg06627628 chr2:24431161 ITSN2 -0.45 -6.51 -0.34 2.87e-10 Sjögren's syndrome; CRC trans rs61931739 0.534 rs1852222 chr12:34008665 C/A cg26384229 chr12:38710491 ALG10B 0.51 6.97 0.36 1.7e-11 Morning vs. evening chronotype; CRC cis rs6502050 0.799 rs6416859 chr17:80111442 G/C cg25804541 chr17:80189381 SLC16A3 -0.31 -5.97 -0.31 6.08e-9 Life satisfaction; CRC cis rs787274 0.543 rs1041086 chr9:115627744 C/G cg13803584 chr9:115635662 SNX30 -0.66 -6.35 -0.33 7.01e-10 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs9303401 0.659 rs12952325 chr17:56899371 G/A cg10487724 chr17:56770010 TEX14;RAD51C 0.76 9.59 0.47 2.2e-19 Cognitive test performance; CRC cis rs910187 0.624 rs6018311 chr20:45792634 A/G cg27589058 chr20:45804311 EYA2 -0.35 -6.47 -0.34 3.64e-10 Migraine; CRC cis rs1336900 0.544 rs10888386 chr1:150611957 A/G cg18016565 chr1:150552671 MCL1 -0.49 -7.04 -0.36 1.1e-11 Blood protein levels; CRC cis rs932287 0.536 rs10840160 chr11:9053536 C/T cg14711859 chr11:8959438 ASCL3 0.38 5.92 0.31 8.09e-9 Colonoscopy-negative controls vs population controls; CRC cis rs561341 0.830 rs2301765 chr17:30202056 T/A cg00745463 chr17:30367425 LRRC37B 0.72 8.35 0.42 1.86e-15 Hip circumference adjusted for BMI; CRC cis rs7119 0.651 rs12904200 chr15:77845902 C/G cg27398640 chr15:77910606 LINGO1 -0.41 -6.85 -0.35 3.59e-11 Type 2 diabetes; CRC cis rs9311676 0.632 rs1126722 chr3:58413518 T/G cg06643156 chr3:58380774 PXK 0.42 6.45 0.33 4.08e-10 Systemic lupus erythematosus; CRC cis rs9325144 0.600 rs12297194 chr12:38735803 A/G cg13010199 chr12:38710504 ALG10B -0.4 -5.95 -0.31 6.86e-9 Morning vs. evening chronotype; CRC cis rs2013441 1.000 rs2107566 chr17:20103252 C/T cg13482628 chr17:19912719 NA -0.44 -6.38 -0.33 6.11e-10 Obesity-related traits; CRC cis rs12188164 0.610 rs57433159 chr5:418725 C/T cg16322479 chr5:444228 EXOC3;C5orf55 0.37 5.94 0.31 7.25e-9 Cystic fibrosis severity; CRC cis rs806215 0.950 rs3735644 chr7:127222157 G/A cg25922125 chr7:127225783 GCC1 -0.71 -7.48 -0.38 6.99e-13 Type 2 diabetes; CRC cis rs561341 1.000 rs530209 chr17:30315287 A/G cg12193833 chr17:30244370 NA -0.75 -8.8 -0.44 7.92e-17 Hip circumference adjusted for BMI; CRC trans rs11098499 1.000 rs28374891 chr4:120183550 G/A cg25214090 chr10:38739885 LOC399744 0.51 7.86 0.4 5.46e-14 Corneal astigmatism; CRC cis rs9457247 0.765 rs9457249 chr6:167426438 A/G cg23791538 chr6:167370224 RNASET2 -0.4 -5.98 -0.31 5.7e-9 Crohn's disease; CRC cis rs1552244 1.000 rs4260416 chr3:10125283 C/T cg02579736 chr3:10068473 FANCD2;CIDECP 0.97 13.18 0.59 3.68e-32 Alzheimer's disease; CRC cis rs2976388 0.609 rs1560986 chr8:143789775 T/C cg24046110 chr8:143859143 LYNX1 0.47 8.18 0.41 6.22e-15 Urinary tract infection frequency; CRC cis rs7737355 0.947 rs31254 chr5:130829404 C/T cg06307176 chr5:131281290 NA 0.41 5.97 0.31 6.13e-9 Life satisfaction; CRC cis rs12701220 0.503 rs12702047 chr7:1132720 G/A cg00990874 chr7:1149470 C7orf50 -0.63 -7.14 -0.37 6.2e-12 Bronchopulmonary dysplasia; CRC cis rs13256369 0.708 rs11249886 chr8:8562021 T/A cg00074818 chr8:8560427 CLDN23 0.4 7.1 0.36 7.63e-12 Obesity-related traits; CRC cis rs853679 0.517 rs9393898 chr6:28130376 G/T cg15786705 chr6:28176104 NA 0.78 9.7 0.47 1.01e-19 Depression; CRC cis rs9435341 0.965 rs12401598 chr1:107580533 C/A cg14671364 chr1:107599128 PRMT6 0.6 8.08 0.41 1.28e-14 Facial morphology (factor 21, depth of nasal alae); CRC cis rs13082711 0.554 rs4973729 chr3:27390637 G/A cg02860705 chr3:27208620 NA 0.86 10.95 0.52 5.42e-24 Systolic blood pressure;Diastolic blood pressure;Blood pressure; CRC cis rs79057730 0.599 rs35928068 chr7:805363 G/C cg06242242 chr7:766104 PRKAR1B;HEATR2 0.66 6.36 0.33 6.58e-10 Initial pursuit acceleration; CRC cis rs72781680 0.611 rs55905755 chr2:24330264 T/C cg06627628 chr2:24431161 ITSN2 -0.55 -6.24 -0.33 1.38e-9 Lymphocyte counts; CRC cis rs10504229 0.817 rs35207430 chr8:58167614 G/A cg01721255 chr8:58191610 C8orf71 0.46 5.91 0.31 8.36e-9 Developmental language disorder (linguistic errors); CRC cis rs10256972 0.706 rs4285396 chr7:1123738 A/G cg07308232 chr7:1071921 C7orf50 -0.47 -6.31 -0.33 8.99e-10 Longevity;Endometriosis; CRC cis rs72634258 0.945 rs2050198 chr1:8111839 T/G cg00042356 chr1:8021962 PARK7 0.66 7.09 0.36 8.35e-12 Inflammatory bowel disease; CRC cis rs4713118 0.621 rs9368548 chr6:28034737 A/G cg02631126 chr6:28058918 ZSCAN12L1 0.28 5.92 0.31 8.29e-9 Parkinson's disease; CRC cis rs3996993 0.809 rs7747087 chr6:52713999 G/A cg20803780 chr6:52668592 GSTA1 -0.38 -7.11 -0.37 7.11e-12 Hemoglobin concentration; CRC cis rs7705042 0.865 rs4912805 chr5:141493685 A/G cg07392085 chr5:141489673 NDFIP1 0.47 7.41 0.38 1.06e-12 Asthma; CRC cis rs2549003 1.000 rs2549009 chr5:131826765 T/C cg21138405 chr5:131827807 IRF1 -0.59 -11.74 -0.54 8.23e-27 Asthma (sex interaction); CRC cis rs9467773 0.595 rs6907924 chr6:26438817 T/G cg09904177 chr6:26538194 HMGN4 -0.44 -6.18 -0.32 1.89e-9 Intelligence (multi-trait analysis); CRC cis rs9549367 0.662 rs3818334 chr13:113825174 C/G cg24300038 chr13:113819356 PROZ -0.46 -5.73 -0.3 2.26e-8 Platelet distribution width; CRC trans rs7395662 0.571 rs4881998 chr11:48525186 C/T cg00717180 chr2:96193071 NA -0.37 -6.1 -0.32 2.99e-9 HDL cholesterol; CRC cis rs10504229 1.000 rs72650900 chr8:58185675 T/A cg01721255 chr8:58191610 C8orf71 0.49 6.17 0.32 2e-9 Developmental language disorder (linguistic errors); CRC cis rs317689 0.581 rs315132 chr12:69761996 G/C cg20891283 chr12:69753455 YEATS4 0.72 10.14 0.49 3.22e-21 Response to diuretic therapy; CRC cis rs4654899 0.680 rs12407731 chr1:21254789 C/T cg02927042 chr1:21476669 EIF4G3 -0.41 -6.38 -0.33 6.12e-10 Superior frontal gyrus grey matter volume; CRC cis rs597539 0.652 rs569777 chr11:68706848 G/A cg21963583 chr11:68658836 MRPL21 0.54 9.62 0.47 1.82e-19 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs3736594 0.765 rs12994085 chr2:27952406 C/T cg27432699 chr2:27873401 GPN1 -0.62 -8.77 -0.44 1e-16 Fasting blood glucose;Fasting blood glucose (BMI interaction); CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg14107975 chr11:96076498 MAML2 0.41 6.65 0.34 1.21e-10 Obesity-related traits; CRC cis rs1862618 0.573 rs832532 chr5:56221938 T/C cg03609598 chr5:56110824 MAP3K1 -0.72 -8.43 -0.42 1.09e-15 Initial pursuit acceleration; CRC cis rs1707322 1.000 rs4660331 chr1:46458783 A/C cg06784218 chr1:46089804 CCDC17 0.52 9.2 0.45 4.11e-18 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs9640161 0.789 rs2373751 chr7:150021599 G/C cg13722127 chr7:150037890 RARRES2 0.52 7.87 0.4 5.35e-14 Blood protein levels;Circulating chemerin levels; CRC cis rs68170813 0.559 rs6967745 chr7:106850548 G/T cg02696742 chr7:106810147 HBP1 -0.6 -6.58 -0.34 1.83e-10 Coronary artery disease; CRC trans rs9903692 0.954 rs875066 chr17:46139732 T/G cg13910583 chr8:56987998 RPS20 -0.45 -6.12 -0.32 2.71e-9 Pulse pressure; CRC cis rs35110281 0.774 rs2838321 chr21:44995488 A/T cg01579765 chr21:45077557 HSF2BP -0.35 -6.57 -0.34 2.02e-10 Mean corpuscular volume; CRC cis rs10504229 1.000 rs67895971 chr8:58177994 A/G cg01721255 chr8:58191610 C8orf71 0.49 6.17 0.32 2e-9 Developmental language disorder (linguistic errors); CRC cis rs9925964 0.933 rs8050894 chr16:31104509 C/G cg03418659 chr16:31128414 MYST1 0.46 6.84 0.35 3.76e-11 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs4727027 1.000 rs4727027 chr7:148869277 C/T cg23583168 chr7:148888333 NA -0.93 -16.59 -0.67 2.35e-45 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC cis rs10078 0.571 rs2561664 chr5:459793 T/C cg08916839 chr5:415575 AHRR 0.83 8.44 0.42 1e-15 Fat distribution (HIV); CRC cis rs1005277 0.691 rs2474558 chr10:38486141 A/C cg25427524 chr10:38739819 LOC399744 0.74 12.33 0.56 5.58e-29 Extrinsic epigenetic age acceleration; CRC cis rs9487051 0.802 rs6910696 chr6:109592329 A/T cg21918786 chr6:109611834 NA -0.44 -7.99 -0.4 2.37e-14 Reticulocyte fraction of red cells; CRC cis rs9291683 0.609 rs34709913 chr4:10028955 T/C cg00071950 chr4:10020882 SLC2A9 0.68 12.89 0.58 4.79e-31 Bone mineral density; CRC cis rs11148252 0.595 rs4885325 chr13:53171317 C/T cg00495681 chr13:53174319 NA 0.85 15.73 0.66 5.53e-42 Lewy body disease; CRC cis rs270601 0.913 rs273916 chr5:131659830 C/A cg12564285 chr5:131593104 PDLIM4 0.46 7.59 0.39 3.36e-13 Acylcarnitine levels; CRC cis rs904251 0.600 rs2270687 chr6:37418263 A/G cg01843034 chr6:37503916 NA -0.37 -6.67 -0.35 1.09e-10 Cognitive performance; CRC cis rs4862750 0.872 rs6553029 chr4:187876470 G/T cg07414643 chr4:187882934 NA -0.41 -7.16 -0.37 5.17e-12 Lobe attachment (rater-scored or self-reported); CRC trans rs12188164 0.515 rs11744936 chr5:412112 C/T cg15371732 chr17:78194151 SLC26A11;SGSH 0.44 6.07 0.32 3.48e-9 Cystic fibrosis severity; CRC cis rs644799 0.672 rs61902245 chr11:95517737 C/T cg03916912 chr11:95522834 CEP57;FAM76B 0.86 15.75 0.66 4.86e-42 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs951366 0.789 rs823095 chr1:205679239 G/A cg23034840 chr1:205782522 SLC41A1 0.46 6.18 0.32 1.88e-9 Menarche (age at onset); CRC cis rs1799949 0.965 rs33961729 chr17:41287924 C/A cg25072359 chr17:41440525 NA 0.44 6.42 0.33 4.86e-10 Menopause (age at onset); CRC cis rs11971779 0.625 rs2355784 chr7:139072493 G/T cg23387468 chr7:139079360 LUC7L2 0.41 7.04 0.36 1.14e-11 Diisocyanate-induced asthma; CRC cis rs6503525 0.591 rs8080734 chr17:38103285 G/A cg26162295 chr17:38119207 GSDMA -0.37 -6.78 -0.35 5.46e-11 Asthma; CRC cis rs10504229 0.728 rs17215851 chr8:58154160 A/C cg22535103 chr8:58192502 C8orf71 -0.68 -8.37 -0.42 1.72e-15 Developmental language disorder (linguistic errors); CRC cis rs8005677 0.962 rs34917191 chr14:23387628 T/C cg25600027 chr14:23388339 RBM23 -0.53 -8.3 -0.42 2.72e-15 Cognitive ability (multi-trait analysis); CRC cis rs4654899 0.965 rs6692244 chr1:21396886 C/A cg02927042 chr1:21476669 EIF4G3 -0.49 -7.71 -0.39 1.51e-13 Superior frontal gyrus grey matter volume; CRC cis rs4713118 0.513 rs200971 chr6:27858904 C/T cg20933634 chr6:27740509 NA 0.49 6.74 0.35 7.32e-11 Parkinson's disease; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg25367318 chr6:138725211 HEBP2 0.53 7.1 0.36 7.89e-12 Thyroid stimulating hormone; CRC cis rs9611565 0.504 rs5758452 chr22:42144927 G/A cg03806693 chr22:41940476 POLR3H 0.66 9.28 0.46 2.43e-18 Vitiligo; CRC cis rs6762 0.748 rs28735718 chr11:839629 A/G cg03885332 chr11:832357 CD151 -0.42 -6.28 -0.33 1.05e-9 Mean platelet volume; CRC cis rs12148488 0.966 rs12899062 chr15:75347641 A/C cg14664628 chr15:75095509 CSK 0.47 6.89 0.36 2.82e-11 Caffeine consumption; CRC cis rs4927850 0.709 rs6783079 chr3:195652708 T/C cg00031303 chr3:195681400 NA 0.72 9.64 0.47 1.51e-19 Pancreatic cancer; CRC cis rs344364 0.511 rs1742395 chr16:1955965 G/A cg09830162 chr16:1889614 FAHD1;C16orf73 -0.74 -9.2 -0.45 4.18e-18 Glomerular filtration rate in chronic kidney disease; CRC cis rs58688157 0.660 rs12797496 chr11:583767 C/T cg07212818 chr11:638076 DRD4 -0.46 -5.84 -0.31 1.23e-8 Systemic lupus erythematosus; CRC cis rs611744 0.647 rs7016198 chr8:109262752 G/A cg18478394 chr8:109455254 TTC35 0.38 5.82 0.31 1.41e-8 Dupuytren's disease; CRC cis rs796364 0.806 rs188102 chr2:200903189 T/A cg23649088 chr2:200775458 C2orf69 -0.63 -6.26 -0.33 1.22e-9 Schizophrenia; CRC cis rs728616 0.867 rs12781912 chr10:81918128 G/T cg11900509 chr10:81946545 ANXA11 -0.74 -8.77 -0.44 9.77e-17 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs9611565 0.918 rs9611566 chr22:41768625 A/G cg17554472 chr22:41940697 POLR3H 0.51 5.68 0.3 2.97e-8 Vitiligo; CRC cis rs34787248 1 rs34787248 chr6:28197886 C/T cg06470822 chr6:28175283 NA 0.81 8.72 0.43 1.41e-16 Autism spectrum disorder or schizophrenia; CRC cis rs6952808 0.862 rs4721135 chr7:1912222 A/G cg22963979 chr7:1858916 MAD1L1 -0.46 -7.29 -0.37 2.31e-12 Bipolar disorder and schizophrenia; CRC cis rs870825 0.616 rs1401360 chr4:185643571 T/C cg04058563 chr4:185651563 MLF1IP 0.72 9.42 0.46 8.15e-19 Blood protein levels; CRC trans rs7395662 0.571 rs4881998 chr11:48525186 C/T cg03929089 chr4:120376271 NA -0.46 -6.52 -0.34 2.7e-10 HDL cholesterol; CRC cis rs11098499 0.954 rs17006190 chr4:120418838 C/G cg09307838 chr4:120376055 NA 0.74 11.38 0.53 1.57e-25 Corneal astigmatism; CRC cis rs2370759 1.000 rs76998371 chr10:32631785 A/G cg01819863 chr10:32635814 EPC1 1.14 13.38 0.59 6.6e-33 Sexual dysfunction (female); CRC cis rs7043114 0.525 rs7847929 chr9:95154244 C/T cg14631576 chr9:95140430 CENPP -0.3 -5.63 -0.3 3.78e-8 Height; CRC trans rs10982213 0.830 rs2274163 chr9:117188714 C/T cg19304507 chr22:30278992 MTMR3 0.4 6.04 0.32 4.23e-9 Interleukin-6 levels; CRC cis rs1799949 1.000 rs33946455 chr17:41321846 C/T cg01879757 chr17:41196368 BRCA1 -0.43 -6.56 -0.34 2.12e-10 Menopause (age at onset); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg02756545 chr1:94884060 ABCD3 0.51 7.16 0.37 5.35e-12 Response to antipsychotic treatment; CRC cis rs703842 0.963 rs2291617 chr12:58166403 T/G cg04478727 chr12:58166393 METTL1;FAM119B 0.42 5.67 0.3 3.06e-8 Multiple sclerosis; CRC cis rs12477438 0.520 rs13023744 chr2:99738224 C/T cg26064155 chr2:99771622 LIPT1;TSGA10 0.91 16.79 0.68 3.83e-46 Chronic sinus infection; CRC trans rs10983614 1.000 rs7867776 chr9:120072627 A/G cg20567499 chr11:107730432 SLC35F2 0.5 7.14 0.37 6.05e-12 Survival in pancreatic cancer; CRC cis rs4730250 0.669 rs6466160 chr7:106793175 T/A cg02696742 chr7:106810147 HBP1 0.56 6.36 0.33 6.77e-10 Osteoarthritis; CRC cis rs72634258 0.796 rs10746475 chr1:8168261 T/A cg00042356 chr1:8021962 PARK7 -0.51 -5.96 -0.31 6.36e-9 Inflammatory bowel disease; CRC cis rs514406 0.929 rs1242224 chr1:53314887 G/A cg27535305 chr1:53392650 SCP2 -0.36 -6.59 -0.34 1.74e-10 Monocyte count; CRC cis rs12824058 0.831 rs11060825 chr12:130807905 A/G cg24838063 chr12:130822603 PIWIL1 0.57 9.55 0.47 3.1e-19 Menopause (age at onset); CRC cis rs1448094 0.511 rs2405621 chr12:86149336 A/T cg02569458 chr12:86230093 RASSF9 -0.46 -7.73 -0.39 1.31e-13 Major depressive disorder; CRC cis rs11608355 0.545 rs36094325 chr12:109911542 A/T cg05360138 chr12:110035743 NA 0.78 8.76 0.43 1.07e-16 Neuroticism; CRC cis rs4808199 0.649 rs12983940 chr19:19516431 G/A cg03709012 chr19:19516395 GATAD2A 1.05 12.92 0.58 3.76e-31 Nonalcoholic fatty liver disease; CRC cis rs1129187 0.755 rs2274514 chr6:42934500 C/T cg00597713 chr6:42947103 PEX6 -0.42 -6.0 -0.31 5.29e-9 Alzheimer's disease in APOE e4+ carriers; CRC cis rs6942756 0.876 rs28636722 chr7:129015151 C/T cg02491457 chr7:128862824 NA -0.61 -8.44 -0.42 1.05e-15 White matter hyperintensity burden; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg00753739 chr10:11653489 USP6NL 0.46 6.5 0.34 2.97e-10 Response to antipsychotic treatment; CRC cis rs734999 0.505 rs10797439 chr1:2540364 G/A cg20673091 chr1:2541236 MMEL1 0.36 5.88 0.31 9.88e-9 Ulcerative colitis; CRC cis rs875971 0.789 rs7808013 chr7:66071196 A/G cg18876405 chr7:65276391 NA -0.54 -8.57 -0.43 4.17e-16 Aortic root size; CRC trans rs1455244 0.700 rs7229302 chr18:11508904 G/T cg13628960 chr20:62258574 GMEB2 0.37 6.05 0.32 3.97e-9 Schizophrenia; CRC trans rs673253 0.686 rs2819333 chr1:44014573 A/T cg24014536 chr3:23847295 UBE2E1 -0.41 -6.14 -0.32 2.39e-9 Intelligence (multi-trait analysis); CRC cis rs4332037 0.624 rs73046339 chr7:1889300 G/A cg13880726 chr7:1868755 MAD1L1 -0.43 -5.8 -0.3 1.55e-8 Bipolar disorder; CRC cis rs1801251 1.000 rs4973054 chr2:233710713 G/C cg25237894 chr2:233734115 C2orf82 -0.54 -8.75 -0.43 1.15e-16 Coronary artery disease; CRC cis rs4665809 1.000 rs12469163 chr2:26283587 T/C cg27170947 chr2:26402098 FAM59B -0.44 -5.85 -0.31 1.21e-8 Gut microbiome composition (summer); CRC cis rs6424115 0.800 rs6665733 chr1:24200158 T/C cg10978503 chr1:24200527 CNR2 0.62 11.22 0.53 6.02e-25 Immature fraction of reticulocytes; CRC cis rs6120849 0.754 rs13433216 chr20:33616301 T/C cg08999081 chr20:33150536 PIGU 0.45 5.79 0.3 1.66e-8 Protein C levels; CRC cis rs2976388 0.609 rs2376491 chr8:143790934 G/A cg12516270 chr8:143859308 LYNX1 0.41 7.42 0.38 9.9e-13 Urinary tract infection frequency; CRC cis rs9916302 0.904 rs12452880 chr17:37591149 G/C cg00129232 chr17:37814104 STARD3 -0.54 -8.05 -0.41 1.48e-14 Glomerular filtration rate (creatinine); CRC cis rs9457247 0.579 rs2181059 chr6:167441624 T/C cg07741184 chr6:167504864 NA 0.35 6.32 0.33 8.58e-10 Crohn's disease; CRC cis rs6662572 0.737 rs6687316 chr1:46581449 G/A cg08644498 chr1:46502608 NA 0.43 7.01 0.36 1.32e-11 Blood protein levels; CRC cis rs11212617 1.000 rs227093 chr11:108233939 T/A cg14761454 chr11:108092087 ATM;NPAT 0.4 5.97 0.31 6.03e-9 Response to metformin in type 2 diabetes (glycemic); CRC cis rs4727027 0.899 rs11771339 chr7:148854132 A/T cg12479418 chr7:148823350 ZNF425;ZNF398 0.43 5.84 0.31 1.24e-8 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC cis rs2976388 1.000 rs1045605 chr8:143764101 C/G cg20041105 chr8:143859282 LYNX1 -0.33 -5.78 -0.3 1.78e-8 Urinary tract infection frequency; CRC cis rs11212617 0.967 rs227072 chr11:108212093 A/C cg01991180 chr11:108092276 ATM;NPAT 0.42 6.27 0.33 1.14e-9 Response to metformin in type 2 diabetes (glycemic); CRC cis rs7727544 0.507 rs10051679 chr5:131570931 T/A cg09877947 chr5:131593287 PDLIM4 0.52 9.41 0.46 8.99e-19 Blood metabolite levels; CRC cis rs5757676 1.000 rs5757676 chr22:39841700 T/C cg24399712 chr22:39784796 NA -0.37 -5.93 -0.31 7.53e-9 IgG glycosylation; CRC cis rs9303401 0.659 rs9303399 chr17:56672309 C/T cg10487724 chr17:56770010 TEX14;RAD51C 0.78 9.44 0.46 7.14e-19 Cognitive test performance; CRC cis rs801193 0.935 rs11772264 chr7:66176387 T/C cg11764359 chr7:65958608 NA 0.55 8.49 0.42 6.96e-16 Aortic root size; CRC trans rs5756813 0.754 rs4821711 chr22:38181115 C/T cg19894588 chr14:64061835 NA -0.55 -7.53 -0.38 4.93e-13 Optic cup area;Vertical cup-disc ratio; CRC trans rs66887589 1.000 rs66887589 chr4:120509279 T/C cg25214090 chr10:38739885 LOC399744 -0.41 -6.31 -0.33 9.11e-10 Diastolic blood pressure; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg06739866 chr14:22314682 NA 0.42 6.16 0.32 2.08e-9 Intelligence (multi-trait analysis); CRC cis rs728616 0.558 rs61859793 chr10:81686763 A/G cg05935833 chr10:81318306 SFTPA2 -0.62 -7.99 -0.4 2.29e-14 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs2153535 0.580 rs1932281 chr6:8473765 A/G cg21535247 chr6:8435926 SLC35B3 0.5 7.53 0.38 4.89e-13 Motion sickness; CRC cis rs875971 0.862 rs6964437 chr7:65686444 A/G cg11764359 chr7:65958608 NA -0.59 -8.75 -0.43 1.17e-16 Aortic root size; CRC cis rs2011503 0.882 rs113841472 chr19:19565482 T/G cg11584989 chr19:19387371 SF4 0.54 6.1 0.32 2.99e-9 Bipolar disorder; CRC cis rs1552244 1.000 rs9820598 chr3:10117912 C/G cg00166722 chr3:10149974 C3orf24 0.67 9.26 0.45 2.71e-18 Alzheimer's disease; CRC cis rs672059 0.513 rs572977 chr1:183164991 C/G cg01949993 chr1:183155116 LAMC2 -0.33 -5.8 -0.3 1.59e-8 Hypertriglyceridemia; CRC cis rs727505 0.954 rs59670428 chr7:124520966 C/A cg23710748 chr7:124431027 NA -0.68 -12.21 -0.56 1.6e-28 Lewy body disease; CRC trans rs9291683 0.588 rs12506364 chr4:10023448 C/T cg26043149 chr18:55253948 FECH 0.51 7.85 0.4 5.92e-14 Bone mineral density; CRC cis rs9486719 0.857 rs3798293 chr6:97033370 A/G cg18709589 chr6:96969512 KIAA0776 -0.55 -6.77 -0.35 5.84e-11 Migraine;Coronary artery disease; CRC cis rs34375054 0.660 rs12578446 chr12:125605887 A/G cg25124228 chr12:125621409 AACS -0.61 -8.51 -0.42 6.32e-16 Post bronchodilator FEV1/FVC ratio; CRC cis rs243505 0.559 rs734003 chr7:148505498 T/G cg09806900 chr7:148480153 CUL1 0.54 7.69 0.39 1.69e-13 Inflammatory bowel disease;Crohn's disease; CRC cis rs853679 0.517 rs9380058 chr6:28127444 T/C cg15845792 chr6:28175446 NA 1.04 13.81 0.61 1.6e-34 Depression; CRC cis rs7618915 0.501 rs12486554 chr3:52742537 A/T cg08222913 chr3:52553049 STAB1 -0.31 -5.73 -0.3 2.23e-8 Bipolar disorder; CRC cis rs12701220 0.655 rs10241018 chr7:1144774 G/C cg00990874 chr7:1149470 C7orf50 -0.71 -9.34 -0.46 1.53e-18 Bronchopulmonary dysplasia; CRC cis rs910316 0.967 rs8013444 chr14:75661981 A/G cg11812906 chr14:75593930 NEK9 -0.52 -7.91 -0.4 3.91e-14 Height; CRC cis rs2898681 0.519 rs76606067 chr4:53728221 G/T cg26260408 chr4:53727979 RASL11B 0.41 5.92 0.31 8.2e-9 Optic nerve measurement (cup area); CRC cis rs3087591 0.960 rs9898664 chr17:29567152 T/C cg24425628 chr17:29625626 OMG;NF1 -0.87 -16.85 -0.68 2.21e-46 Hip circumference; CRC cis rs9811920 0.541 rs1016914 chr3:99640121 C/T cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G 0.46 6.18 0.32 1.87e-9 Axial length; CRC cis rs4237845 0.591 rs4760344 chr12:58320783 A/T cg23860436 chr12:58378763 NA 0.35 5.88 0.31 1.03e-8 Intelligence (multi-trait analysis); CRC cis rs2228479 0.702 rs17226841 chr16:89828484 C/T cg06558623 chr16:89946397 TCF25 1.13 10.45 0.5 2.85e-22 Skin colour saturation; CRC cis rs977987 0.806 rs1364077 chr16:75396991 C/T cg03315344 chr16:75512273 CHST6 0.54 9.07 0.45 1.13e-17 Dupuytren's disease; CRC cis rs6860806 0.531 rs272888 chr5:131665423 T/C cg18758796 chr5:131593413 PDLIM4 0.39 6.26 0.33 1.23e-9 Breast cancer; CRC cis rs7587476 0.784 rs13008641 chr2:215698033 T/C cg04004882 chr2:215674386 BARD1 0.66 9.21 0.45 4.08e-18 Neuroblastoma; CRC cis rs9858542 0.537 rs9864406 chr3:49352619 A/G cg00383909 chr3:49044727 WDR6 0.6 6.88 0.35 3.04e-11 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs9733 0.596 rs6685702 chr1:150656307 A/G cg15448220 chr1:150897856 SETDB1 0.45 6.43 0.33 4.42e-10 Tonsillectomy; CRC cis rs10504229 0.728 rs17804365 chr8:58151537 C/A cg02725872 chr8:58115012 NA -0.57 -9.07 -0.45 1.09e-17 Developmental language disorder (linguistic errors); CRC cis rs10499694 0.967 rs11765748 chr7:50615616 T/A cg14593290 chr7:50529359 DDC -0.43 -6.26 -0.33 1.2e-9 Body mass index; CRC cis rs11148252 0.774 rs7334583 chr13:52930352 G/T cg00495681 chr13:53174319 NA -0.65 -10.2 -0.49 2.08e-21 Lewy body disease; CRC cis rs11711311 0.955 rs9851812 chr3:113412362 G/A cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.47 -6.25 -0.33 1.27e-9 IgG glycosylation; CRC cis rs9462027 0.628 rs1998702 chr6:34741917 A/G cg07306190 chr6:34760872 UHRF1BP1 -0.34 -6.12 -0.32 2.72e-9 Systemic lupus erythematosus; CRC cis rs10504229 0.683 rs11784908 chr8:58131472 T/C cg22535103 chr8:58192502 C8orf71 -0.7 -9.34 -0.46 1.47e-18 Developmental language disorder (linguistic errors); CRC cis rs6840360 0.571 rs4696110 chr4:152671325 G/A cg09659197 chr4:152720779 NA 0.43 8.9 0.44 3.94e-17 Intelligence (multi-trait analysis); CRC trans rs7944735 0.517 rs11039538 chr11:48154990 A/T cg15704280 chr7:45808275 SEPT13 0.65 5.97 0.31 6.07e-9 Intraocular pressure; CRC trans rs3749237 1.000 rs11717256 chr3:49868520 C/T cg21659725 chr3:3221576 CRBN 0.58 8.38 0.42 1.57e-15 Resting heart rate; CRC cis rs12824058 0.831 rs7485200 chr12:130811641 C/T cg24838063 chr12:130822603 PIWIL1 0.57 9.45 0.46 6.45e-19 Menopause (age at onset); CRC cis rs67311347 1.000 rs28707772 chr3:40504666 G/A cg24209194 chr3:40518798 ZNF619 0.41 5.71 0.3 2.58e-8 Renal cell carcinoma; CRC cis rs10504229 0.683 rs55807014 chr8:58131801 T/C cg05313129 chr8:58192883 C8orf71 -0.43 -6.11 -0.32 2.74e-9 Developmental language disorder (linguistic errors); CRC cis rs8022206 0.898 rs1980850 chr14:68647188 A/G cg19578161 chr14:68482919 RAD51L1 0.43 5.76 0.3 1.95e-8 Platelet count;Mean platelet volume; CRC cis rs769267 0.930 rs10419912 chr19:19597055 A/G cg02546618 chr19:19431379 KIAA0892;SF4 -0.45 -6.14 -0.32 2.37e-9 Tonsillectomy; CRC cis rs4953076 0.574 rs4953074 chr2:44464629 C/T cg04920474 chr2:44395004 PPM1B 0.63 8.71 0.43 1.54e-16 Height; CRC cis rs972578 0.806 rs5758955 chr22:43217149 G/C cg01576275 chr22:43409880 NA -0.42 -6.56 -0.34 2.05e-10 Mean platelet volume; CRC cis rs1799949 0.930 rs56729776 chr17:41422131 C/T cg19454999 chr17:41278357 BRCA1;NBR2 0.53 8.06 0.41 1.47e-14 Menopause (age at onset); CRC cis rs4689388 0.926 rs5018647 chr4:6292799 A/C cg14416269 chr4:6271139 WFS1 0.39 6.52 0.34 2.7e-10 Type 2 diabetes and other traits;Type 2 diabetes; CRC cis rs11190604 1.000 rs2489046 chr10:102346282 A/C cg07080220 chr10:102295463 HIF1AN 0.49 6.33 0.33 8.03e-10 Palmitoleic acid (16:1n-7) levels; CRC cis rs4665809 0.627 rs1465720 chr2:26412638 G/T cg26119090 chr2:26468346 HADHA;HADHB -1.02 -14.32 -0.62 1.72e-36 Gut microbiome composition (summer); CRC cis rs9463078 0.678 rs9395088 chr6:45240267 G/A cg25276700 chr6:44698697 NA -0.24 -5.87 -0.31 1.04e-8 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; CRC cis rs7772486 0.875 rs854146 chr6:146341033 A/G cg13319975 chr6:146136371 FBXO30 -0.39 -5.88 -0.31 1.03e-8 Lobe attachment (rater-scored or self-reported); CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg09730672 chr8:86157838 CA13 0.46 6.37 0.33 6.46e-10 Anxiety disorder; CRC cis rs12580194 0.593 rs12579346 chr12:55786856 A/G cg23425280 chr12:56401806 NA 0.47 5.71 0.3 2.53e-8 Cancer; CRC cis rs9488822 0.636 rs1544155 chr6:116346394 C/A cg05304507 chr6:116381966 FRK 0.32 8.55 0.43 4.55e-16 Cholesterol, total;LDL cholesterol; CRC cis rs1564271 0.553 rs2489583 chr10:26987698 A/G cg13837822 chr10:26931731 LOC731789 0.56 8.62 0.43 2.92e-16 Overall survival in serous epithelial ovarian cancer treated with paclitaxel and cisplatin; CRC cis rs9611565 0.512 rs139566 chr22:42199277 A/G cg06634786 chr22:41940651 POLR3H -0.69 -7.76 -0.39 1.07e-13 Vitiligo; CRC cis rs2718798 1 rs2718798 chr3:133492088 A/C cg08048268 chr3:133502702 NA -0.4 -7.41 -0.38 1.09e-12 Ankle injury; CRC cis rs6461049 0.800 rs3778977 chr7:2159746 C/T cg21782813 chr7:2030301 MAD1L1 0.5 9.16 0.45 5.76e-18 Schizophrenia; CRC cis rs2243480 0.901 rs73142137 chr7:65343442 A/T cg25985355 chr7:65971099 NA -0.5 -5.69 -0.3 2.86e-8 Diabetic kidney disease; CRC trans rs208515 0.525 rs1351866 chr6:66696969 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.96 12.25 0.56 1.12e-28 Exhaled nitric oxide levels; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg24088775 chr19:12595630 ZNF709 0.4 6.4 0.33 5.31e-10 Liver disease severity in Alagille syndrome; CRC cis rs8017423 0.522 rs12887028 chr14:90819605 A/G cg14092571 chr14:90743983 NA 0.39 5.98 0.31 5.81e-9 Mortality in heart failure; CRC cis rs13108904 0.935 rs3755920 chr4:1243617 T/C cg00684032 chr4:1343700 KIAA1530 0.4 5.87 0.31 1.09e-8 Obesity-related traits; CRC cis rs747650 0.504 rs4752815 chr11:46978698 G/A cg19486271 chr11:47235900 DDB2 -0.44 -5.84 -0.31 1.24e-8 Acne (severe); CRC cis rs1957429 0.901 rs6573583 chr14:65351211 G/T cg23373153 chr14:65346875 NA 0.8 8.31 0.42 2.59e-15 Pediatric areal bone mineral density (radius); CRC cis rs4268898 0.662 rs2303297 chr2:24432937 C/T cg06627628 chr2:24431161 ITSN2 -0.85 -11.58 -0.54 3.01e-26 Asthma; CRC trans rs7267979 1.000 rs6037105 chr20:25374199 C/A cg17903999 chr18:56338584 MALT1 0.42 6.98 0.36 1.63e-11 Liver enzyme levels (alkaline phosphatase); CRC cis rs7647973 0.961 rs4955417 chr3:49298205 T/C cg20833759 chr3:49053208 WDR6;DALRD3 0.53 8.04 0.41 1.62e-14 Menarche (age at onset); CRC cis rs600806 0.815 rs10858094 chr1:109950858 T/C cg23032129 chr1:109941072 SORT1 -0.29 -6.16 -0.32 2.08e-9 Intelligence (multi-trait analysis); CRC trans rs17780086 0.527 rs72827711 chr17:30537920 T/A cg00801512 chr17:28996047 NA -0.6 -6.1 -0.32 2.91e-9 Height; CRC cis rs4731207 0.698 rs10271687 chr7:124493731 C/T cg23710748 chr7:124431027 NA -0.38 -6.08 -0.32 3.42e-9 Cutaneous malignant melanoma; CRC cis rs9916302 0.904 rs11655531 chr17:37697959 T/C cg03013999 chr17:37608204 MED1 0.46 7.16 0.37 5.4e-12 Glomerular filtration rate (creatinine); CRC cis rs10256972 0.684 rs2363279 chr7:1096143 A/G cg07308232 chr7:1071921 C7orf50 -0.51 -7.21 -0.37 3.77e-12 Longevity;Endometriosis; CRC cis rs739401 0.588 rs10219272 chr11:3020789 G/A cg05729581 chr11:3078854 CARS -0.58 -8.61 -0.43 3.08e-16 Longevity; CRC cis rs4862750 0.794 rs7692427 chr4:187901727 G/A cg22105103 chr4:187893119 NA 0.64 11.71 0.54 1.01e-26 Lobe attachment (rater-scored or self-reported); CRC cis rs919433 0.714 rs2333855 chr2:198200213 T/G cg10820045 chr2:198174542 NA -0.48 -8.41 -0.42 1.31e-15 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC cis rs12477438 0.520 rs13010904 chr2:99754289 G/A cg26064155 chr2:99771622 LIPT1;TSGA10 0.9 16.76 0.68 4.95e-46 Chronic sinus infection; CRC trans rs10504229 1.000 rs59549824 chr8:58186205 A/C cg04077850 chr5:125800366 GRAMD3 0.38 6.29 0.33 9.98e-10 Developmental language disorder (linguistic errors); CRC cis rs6938 0.514 rs35556055 chr15:75253414 G/A cg18612461 chr15:75251733 NA 0.47 7.2 0.37 4.03e-12 Breast cancer; CRC cis rs13191362 0.938 rs13208970 chr6:163006368 G/T cg21926612 chr6:163149169 PACRG;PARK2 0.76 11.15 0.52 1.03e-24 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs7216064 0.953 rs11871285 chr17:65840809 G/T cg12091567 chr17:66097778 LOC651250 -0.68 -7.87 -0.4 5.31e-14 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CRC cis rs514406 0.861 rs4926932 chr1:53247495 C/T cg08859206 chr1:53392774 SCP2 0.44 6.74 0.35 7.19e-11 Monocyte count; CRC trans rs875971 0.660 rs2191268 chr7:66110224 C/T cg10529930 chr20:5986407 CRLS1 -0.38 -6.12 -0.32 2.72e-9 Aortic root size; CRC cis rs6570726 0.935 rs367643 chr6:145859602 A/C cg05347473 chr6:146136440 FBXO30 0.38 6.05 0.32 4e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs9393692 0.557 rs9379846 chr6:26314238 G/C cg13736514 chr6:26305472 NA -0.45 -7.24 -0.37 3.18e-12 Educational attainment; CRC cis rs17234274 0.644 rs10833965 chr11:23214880 A/G cg05245346 chr11:23248277 NA 0.36 5.93 0.31 7.53e-9 Cancer; CRC cis rs6502050 0.761 rs9908277 chr17:80060829 T/C cg02741985 chr17:80059408 CCDC57 -0.45 -7.28 -0.37 2.49e-12 Life satisfaction; CRC cis rs2019137 0.539 rs4849177 chr2:113982584 T/C cg07594247 chr2:113993304 PAX8;LOC440839;LOC654433 0.48 7.48 0.38 6.81e-13 Lymphocyte counts; CRC trans rs1728785 1.000 rs698716 chr16:68560296 C/T cg04657470 chr2:198365150 HSPE1;HSPD1 0.72 8.24 0.41 4.21e-15 Ulcerative colitis; CRC cis rs3617 0.539 rs11130331 chr3:52956918 G/A cg11645453 chr3:52864694 ITIH4 -0.39 -7.67 -0.39 1.97e-13 Red blood cell count;Autism spectrum disorder or schizophrenia; CRC cis rs2944755 0.959 rs2977491 chr8:141574277 A/G cg07466463 chr8:141574207 EIF2C2 0.4 5.96 0.31 6.33e-9 Thiazide-induced adverse metabolic effects in hypertensive patients; CRC cis rs2576037 0.583 rs8098948 chr18:44512332 C/A cg07643061 chr18:44555308 TCEB3C;TCEB3CL;KATNAL2 -0.33 -5.61 -0.3 4.38e-8 Personality dimensions; CRC trans rs11252926 0.673 rs7096559 chr10:499188 C/T cg00953403 chr17:74099816 EXOC7 0.47 7.08 0.36 8.79e-12 Psychosis in Alzheimer's disease; CRC cis rs7829975 0.593 rs2921077 chr8:8304502 C/T cg06636001 chr8:8085503 FLJ10661 0.62 9.94 0.48 1.62e-20 Mood instability; CRC cis rs7635838 0.819 rs6776159 chr3:11519324 A/G cg00170343 chr3:11313890 ATG7 0.43 6.53 0.34 2.53e-10 HDL cholesterol; CRC cis rs9549367 0.789 rs7994324 chr13:113906497 T/C cg00898013 chr13:113819073 PROZ -0.46 -6.47 -0.34 3.56e-10 Platelet distribution width; CRC cis rs6951245 1.000 rs75488469 chr7:1102122 A/G cg26224354 chr7:1096374 C7orf50;GPR146 -0.91 -11.72 -0.54 9.81e-27 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs7703744 0.597 rs73237297 chr5:118691121 G/T cg19893178 chr5:118692011 TNFAIP8 0.42 5.78 0.3 1.69e-8 Lobe attachment (rater-scored or self-reported); CRC cis rs35110281 0.622 rs9977258 chr21:44976485 G/T cg01579765 chr21:45077557 HSF2BP -0.37 -6.87 -0.35 3.17e-11 Mean corpuscular volume; CRC cis rs713477 0.845 rs4898863 chr14:55910284 T/A cg13175173 chr14:55914753 NA -0.47 -8.89 -0.44 4.25e-17 Pediatric bone mineral content (femoral neck); CRC cis rs13191362 1.000 rs13210756 chr6:163009030 T/A cg23758597 chr6:163146217 PARK2 -0.51 -5.9 -0.31 8.81e-9 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs875971 0.862 rs778736 chr7:65813848 C/T cg12463550 chr7:65579703 CRCP 0.49 6.58 0.34 1.85e-10 Aortic root size; CRC cis rs10504229 1.000 rs7007805 chr8:58179327 G/A cg02725872 chr8:58115012 NA -0.38 -6.43 -0.33 4.44e-10 Developmental language disorder (linguistic errors); CRC cis rs7827545 1.000 rs4909909 chr8:135564627 T/C cg17885191 chr8:135476712 NA 0.54 7.41 0.38 1.06e-12 Hypertension (SNP x SNP interaction); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg26056348 chr7:75932317 HSPB1 0.38 6.17 0.32 1.97e-9 Liver disease severity in Alagille syndrome; CRC cis rs68170813 0.559 rs12537785 chr7:107050221 T/C cg02696742 chr7:106810147 HBP1 -0.61 -6.64 -0.34 1.34e-10 Coronary artery disease; CRC cis rs4808199 0.895 rs4808196 chr19:19476520 G/A cg03709012 chr19:19516395 GATAD2A 1.03 12.39 0.56 3.54e-29 Nonalcoholic fatty liver disease; CRC cis rs3008870 1.000 rs1137656 chr1:67451602 A/C cg08660285 chr1:67390436 MIER1;WDR78 -1.04 -15.24 -0.64 4.66e-40 Lymphocyte percentage of white cells; CRC cis rs6460942 0.915 rs62448623 chr7:12464122 A/G cg20607287 chr7:12443886 VWDE -0.66 -6.93 -0.36 2.17e-11 Coronary artery disease; CRC cis rs875971 0.862 rs11773628 chr7:65982631 G/T cg00343986 chr7:65444356 GUSB -0.42 -5.98 -0.31 5.91e-9 Aortic root size; CRC trans rs116095464 0.558 rs13356367 chr5:242395 C/T cg00938859 chr5:1591904 SDHAP3 0.72 7.76 0.39 1.09e-13 Breast cancer; CRC cis rs3820928 0.874 rs2272198 chr2:227893017 A/G cg11843606 chr2:227700838 RHBDD1 0.39 5.71 0.3 2.58e-8 Pulmonary function; CRC cis rs11252926 0.931 rs12355162 chr10:563472 G/A cg03684893 chr10:554711 DIP2C 0.37 5.65 0.3 3.5e-8 Psychosis in Alzheimer's disease; CRC cis rs10504229 1.000 rs112272435 chr8:58170371 A/G cg24829409 chr8:58192753 C8orf71 -0.68 -11.34 -0.53 2.27e-25 Developmental language disorder (linguistic errors); CRC cis rs1153858 1.000 rs1980288 chr15:45620612 T/C cg14582100 chr15:45693742 SPATA5L1 0.29 5.98 0.31 5.72e-9 Homoarginine levels; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg17218029 chr1:156722047 HDGF 0.38 6.12 0.32 2.64e-9 Intelligence (multi-trait analysis); CRC cis rs10540 1.000 rs61876341 chr11:495892 C/G cg19913688 chr11:428466 ANO9 -0.7 -7.21 -0.37 3.76e-12 Body mass index; CRC cis rs4716602 0.596 rs10270517 chr7:156160010 A/G cg16983916 chr7:156159713 NA -0.39 -6.9 -0.36 2.74e-11 Anti-saccade response; CRC cis rs9527 0.590 rs11191544 chr10:104827198 C/G cg04362960 chr10:104952993 NT5C2 0.59 8.32 0.42 2.4e-15 Arsenic metabolism; CRC cis rs853679 0.517 rs9393891 chr6:28079160 C/T cg23161317 chr6:28129485 ZNF389 0.54 6.56 0.34 2.12e-10 Depression; CRC cis rs10479542 0.583 rs4131080 chr5:179044292 G/A cg19626725 chr5:178986131 RUFY1 0.33 6.09 0.32 3.21e-9 Lung cancer; CRC cis rs7647973 0.559 rs9586 chr3:49213637 C/T cg07636037 chr3:49044803 WDR6 0.59 6.99 0.36 1.57e-11 Menarche (age at onset); CRC cis rs12142240 0.698 rs17357711 chr1:46829013 A/G cg00530320 chr1:46809349 NSUN4 0.59 8.11 0.41 1.02e-14 Menopause (age at onset); CRC cis rs743757 1.000 rs2282754 chr3:50436827 T/C cg09545109 chr3:50388910 TUSC4;CYB561D2 0.44 6.23 0.32 1.46e-9 Diastolic blood pressure; CRC trans rs208520 0.690 rs12201156 chr6:66720874 G/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.97 13.62 0.6 8.16e-34 Exhaled nitric oxide output; CRC cis rs2739330 0.627 rs9608219 chr22:24274119 G/C cg04234412 chr22:24373322 LOC391322 -0.86 -15.31 -0.64 2.54e-40 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs9427116 0.502 rs9427104 chr1:154589232 C/T cg17218026 chr1:154582156 ADAR 0.69 12.57 0.57 7.09e-30 Blood protein levels; CRC cis rs951366 0.789 rs864783 chr1:205711974 T/C cg11965913 chr1:205819406 PM20D1 0.82 13.01 0.58 1.63e-31 Menarche (age at onset); CRC cis rs1448094 0.791 rs61929394 chr12:86331541 C/A cg02569458 chr12:86230093 RASSF9 0.45 7.66 0.39 2.16e-13 Major depressive disorder; CRC cis rs10540 0.908 rs71487293 chr11:486414 G/A cg21784768 chr11:537496 LRRC56 -0.67 -6.21 -0.32 1.63e-9 Body mass index; CRC cis rs10504229 0.683 rs34804288 chr8:58117570 C/A cg04204079 chr8:58130323 NA -0.45 -5.78 -0.3 1.71e-8 Developmental language disorder (linguistic errors); CRC cis rs34172651 0.876 rs11074653 chr16:24795959 C/T cg00339695 chr16:24857497 SLC5A11 0.28 6.29 0.33 1.01e-9 Intelligence (multi-trait analysis); CRC cis rs7615952 0.599 rs67575510 chr3:125742355 C/G cg05084668 chr3:125655381 ALG1L -0.44 -6.16 -0.32 2.09e-9 Blood pressure (smoking interaction); CRC trans rs5756813 0.700 rs1894525 chr22:38186400 G/A cg19894588 chr14:64061835 NA -0.56 -7.49 -0.38 6.22e-13 Optic cup area;Vertical cup-disc ratio; CRC cis rs7811142 0.830 rs11771936 chr7:99943283 A/G cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.17 16.62 0.68 1.76e-45 Platelet count; CRC cis rs7617480 0.610 rs10865954 chr3:49211989 T/C cg03060546 chr3:49711283 APEH 0.5 7.65 0.39 2.18e-13 Subjective well-being (multi-trait analysis);Menarche (age at onset); CRC cis rs939584 1.000 rs10169736 chr2:641082 A/T cg03610516 chr2:642275 NA 0.42 5.88 0.31 9.94e-9 Body mass index; CRC cis rs10416265 0.503 rs1981818 chr19:33615122 C/T cg27124370 chr19:33622961 WDR88 -0.44 -6.65 -0.34 1.25e-10 Bone properties (heel); CRC cis rs6088580 0.584 rs2378203 chr20:32993846 A/T cg08999081 chr20:33150536 PIGU -0.61 -11.56 -0.54 3.46e-26 Glomerular filtration rate (creatinine); CRC cis rs3750965 1.000 rs7937006 chr11:68843932 C/T cg06818126 chr11:68850279 TPCN2 -0.51 -7.16 -0.37 5.22e-12 Hair color; CRC cis rs728616 0.867 rs56123058 chr10:81811072 G/A cg11900509 chr10:81946545 ANXA11 -0.53 -5.78 -0.3 1.69e-8 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs853679 0.517 rs9393898 chr6:28130376 G/T cg06470822 chr6:28175283 NA 1.01 13.28 0.59 1.55e-32 Depression; CRC trans rs7647973 0.626 rs9829155 chr3:49817450 T/C cg21659725 chr3:3221576 CRBN 0.63 7.03 0.36 1.21e-11 Menarche (age at onset); CRC trans rs7615952 0.512 rs2979351 chr3:125363599 C/T cg02007433 chr3:129722099 NA -0.61 -9.23 -0.45 3.37e-18 Blood pressure (smoking interaction); CRC trans rs561341 0.739 rs4795663 chr17:30214542 T/C cg20587970 chr11:113659929 NA 0.53 7.28 0.37 2.52e-12 Hip circumference adjusted for BMI; CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg09880681 chr16:30538664 ZNF768 -0.53 -6.4 -0.33 5.29e-10 Diisocyanate-induced asthma; CRC cis rs910316 1.000 rs4322591 chr14:75600697 C/T cg08847533 chr14:75593920 NEK9 0.94 18.35 0.71 2.78e-52 Height; CRC cis rs875971 0.862 rs6960446 chr7:65733259 A/G cg00343986 chr7:65444356 GUSB -0.45 -6.2 -0.32 1.72e-9 Aortic root size; CRC cis rs6570726 0.791 rs9399558 chr6:145911730 T/C cg05347473 chr6:146136440 FBXO30 0.39 5.89 0.31 9.49e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs7312774 0.618 rs7975954 chr12:107345750 C/T cg16260113 chr12:107380972 MTERFD3 0.79 8.09 0.41 1.18e-14 Severe influenza A (H1N1) infection; CRC cis rs9486715 0.867 rs1855533 chr6:97050265 T/C cg18709589 chr6:96969512 KIAA0776 -0.5 -7.55 -0.38 4.38e-13 Headache; CRC cis rs9910055 0.762 rs11080007 chr17:42265442 A/G cg16434002 chr17:42200994 HDAC5 0.44 5.86 0.31 1.15e-8 Total body bone mineral density; CRC cis rs7246865 0.906 rs2278997 chr19:17166981 G/A cg19418318 chr19:17219073 MYO9B 0.42 6.81 0.35 4.61e-11 Reticulocyte fraction of red cells; CRC trans rs60843830 1.000 rs3791223 chr2:222336 T/C cg11347411 chr7:150020925 ACTR3C;LRRC61 0.59 9.0 0.44 1.84e-17 Spherical equivalent (joint analysis main effects and education interaction); CRC cis rs9388451 0.872 rs2008027 chr6:126052359 A/G cg05901451 chr6:126070800 HEY2 -0.66 -11.37 -0.53 1.67e-25 Brugada syndrome; CRC cis rs875971 0.545 rs73376401 chr7:65639828 G/A cg02869306 chr7:64672164 INTS4L1 -0.44 -6.45 -0.33 4.03e-10 Aortic root size; CRC cis rs68170813 0.559 rs2395881 chr7:107074323 A/C cg02696742 chr7:106810147 HBP1 -0.58 -6.04 -0.32 4.16e-9 Coronary artery disease; CRC cis rs9462846 0.853 rs7741552 chr6:42873823 A/G cg21280719 chr6:42927975 GNMT -0.33 -6.43 -0.33 4.47e-10 Blood protein levels; CRC cis rs477692 1.000 rs480643 chr10:131400308 A/G cg05714579 chr10:131428358 MGMT 0.54 7.61 0.39 2.89e-13 Response to temozolomide; CRC cis rs172166 0.637 rs1225595 chr6:28151340 A/T cg06470822 chr6:28175283 NA 0.84 13.01 0.58 1.61e-31 Cardiac Troponin-T levels; CRC trans rs2303319 0.504 rs12467613 chr2:162603216 G/T cg22677401 chr17:46026860 NA -0.67 -6.07 -0.32 3.57e-9 Cognitive function; CRC cis rs741668 0.931 rs2806926 chr13:46521667 A/G cg06018095 chr13:46550134 ZC3H13 0.43 6.34 0.33 7.39e-10 Cerebrospinal fluid clusterin levels; CRC cis rs17253792 0.822 rs80328469 chr14:56067701 G/A cg01858014 chr14:56050164 KTN1 -0.87 -7.23 -0.37 3.34e-12 Putamen volume; CRC cis rs11105298 0.786 rs10777186 chr12:89921277 G/A cg08166232 chr12:89918718 WDR51B;GALNT4 -0.63 -7.88 -0.4 4.75e-14 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; CRC cis rs853679 0.550 rs9295762 chr6:28155418 C/T cg03623178 chr6:28175578 NA -0.94 -13.51 -0.6 2.23e-33 Depression; CRC cis rs7605827 0.930 rs1990754 chr2:15615910 A/G cg19274914 chr2:15703543 NA 0.39 5.9 0.31 8.83e-9 Educational attainment (years of education); CRC cis rs17270561 0.553 rs9379784 chr6:25725506 A/G cg16482183 chr6:26056742 HIST1H1C 0.74 9.35 0.46 1.41e-18 Iron status biomarkers; CRC cis rs9814567 0.896 rs6799110 chr3:134206749 T/C cg06109529 chr3:134205091 CEP63;ANAPC13 -0.83 -12.65 -0.57 3.57e-30 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs9733 0.596 rs12086472 chr1:150697710 G/A cg18016565 chr1:150552671 MCL1 0.45 6.52 0.34 2.57e-10 Tonsillectomy; CRC cis rs9291683 0.597 rs11723016 chr4:10126189 A/G cg11266682 chr4:10021025 SLC2A9 -0.45 -8.86 -0.44 5.23e-17 Bone mineral density; CRC cis rs4919694 0.536 rs12256506 chr10:104963618 T/A cg04362960 chr10:104952993 NT5C2 0.89 9.04 0.45 1.37e-17 Arsenic metabolism; CRC cis rs67478160 0.575 rs8014294 chr14:104322983 A/G cg08213375 chr14:104286397 PPP1R13B 0.56 11.08 0.52 1.87e-24 Schizophrenia; CRC cis rs823143 0.570 rs823084 chr1:205798313 G/T cg14159672 chr1:205819179 PM20D1 0.63 9.49 0.46 4.69e-19 Monocyte percentage of white cells; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg03628274 chr19:18420511 LSM4 -0.38 -6.02 -0.31 4.58e-9 Liver disease severity in Alagille syndrome; CRC trans rs4942242 0.763 rs7326281 chr13:44233186 G/A cg27382691 chr15:76552771 ETFA;TYRO3P -0.45 -6.0 -0.31 5.19e-9 Response to tocilizumab in rheumatoid arthritis; CRC cis rs1881797 1.000 rs1881797 chr1:247689532 A/G cg21399703 chr1:247681439 NA 0.54 10.2 0.49 2.08e-21 Acute lymphoblastic leukemia (childhood); CRC cis rs10504229 0.683 rs11775506 chr8:58133639 G/T cg22535103 chr8:58192502 C8orf71 -0.69 -9.14 -0.45 6.55e-18 Developmental language disorder (linguistic errors); CRC trans rs637571 0.726 rs669371 chr11:65674153 G/T cg17712092 chr4:129076599 LARP1B -0.75 -12.61 -0.57 5.12e-30 Eosinophil percentage of white cells; CRC cis rs1862618 0.511 rs2591952 chr5:56120769 T/A cg22800045 chr5:56110881 MAP3K1 0.55 6.09 0.32 3.15e-9 Initial pursuit acceleration; CRC cis rs2075671 0.903 rs4727459 chr7:100276821 T/C cg16850897 chr7:100343110 ZAN -0.61 -8.98 -0.44 2.11e-17 Other erythrocyte phenotypes; CRC cis rs172166 0.637 rs1225597 chr6:28162087 C/T cg20615401 chr6:28092323 ZSCAN16 0.42 5.61 0.3 4.21e-8 Cardiac Troponin-T levels; CRC cis rs1506636 1.000 rs656425 chr7:123424525 A/C cg03229431 chr7:123269106 ASB15 0.73 11.68 0.54 1.34e-26 Plateletcrit;Platelet count; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg01853632 chr3:43147395 C3orf39 0.4 6.72 0.35 7.84e-11 Liver disease severity in Alagille syndrome; CRC cis rs3749237 0.537 rs4459909 chr3:49469217 T/C cg02487422 chr3:49467188 NICN1 0.41 6.71 0.35 8.45e-11 Resting heart rate; CRC cis rs12188164 0.930 rs72717440 chr5:449701 A/T cg15813090 chr5:442598 EXOC3;C5orf55 0.39 5.63 0.3 3.9e-8 Cystic fibrosis severity; CRC cis rs1799949 1.000 rs11651341 chr17:41428061 T/C cg19454999 chr17:41278357 BRCA1;NBR2 0.52 8.15 0.41 7.66e-15 Menopause (age at onset); CRC cis rs2549003 0.966 rs2070730 chr5:131819800 G/A cg21138405 chr5:131827807 IRF1 0.57 11.38 0.53 1.59e-25 Asthma (sex interaction); CRC cis rs6942756 0.806 rs2718115 chr7:128871532 A/G cg02491457 chr7:128862824 NA 0.64 9.03 0.45 1.44e-17 White matter hyperintensity burden; CRC cis rs12681287 0.547 rs10087788 chr8:87544174 G/A cg27223183 chr8:87520930 FAM82B 0.5 6.72 0.35 7.91e-11 Caudate activity during reward; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg08748207 chr12:46777589 NA 0.52 6.84 0.35 3.97e-11 Thyroid stimulating hormone; CRC cis rs780094 0.500 rs12987055 chr2:27834152 T/C cg27432699 chr2:27873401 GPN1 0.48 6.18 0.32 1.91e-9 Calcium levels;Fasting blood insulin;Metabolic traits;Triglyceride levels;Fasting plasma glucose;Urate levels in overweight individuals;Urate levels in obese individuals;Uric acid levels;Height;Age-related diseases, mortality and associated endophenotypes;Renal underexcretion gout;Fasting blood glucose (BMI interaction);Urate levels;Gondoic acid (20:1n-9) levels;Fasting blood insulin (BMI interaction);Triglycerides;Plasma omega-3 polyunsaturated fatty acid levels (docosapentaenoic acid);Type 2 diabetes;Nonalcoholic fatty liver disease;Hypertriglyceridemia;C-reactive protein;Age-related disease endophenotypes;LDL cholesterol;Metabolic syndrome;Crohn's disease;Alcohol consumption (drinks per week);Homeostasis model assessment of insulin resistance;Alcohol consumption;Red blood cell count;Fasting blood glucose; CRC cis rs559928 0.606 rs78038516 chr11:63978067 C/G cg19465662 chr11:63993652 NUDT22;TRPT1 0.71 6.86 0.35 3.5e-11 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; CRC cis rs873946 0.648 rs12782123 chr10:134554662 G/A cg18305652 chr10:134549665 INPP5A 0.5 6.42 0.33 4.77e-10 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CRC cis rs4332037 0.539 rs11764590 chr7:2032803 C/T cg02825527 chr7:2087843 MAD1L1 -0.49 -5.83 -0.31 1.34e-8 Bipolar disorder; CRC cis rs9487051 0.807 rs1915835 chr6:109597483 C/T cg21918786 chr6:109611834 NA -0.43 -7.79 -0.39 8.71e-14 Reticulocyte fraction of red cells; CRC cis rs9584850 0.789 rs7988345 chr13:99117685 A/G cg20487152 chr13:99095054 FARP1 0.43 6.29 0.33 1.01e-9 Neuroticism; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg04088893 chr5:149340277 SLC26A2 0.45 6.4 0.33 5.31e-10 Response to antipsychotic treatment; CRC cis rs12190007 0.508 rs9406321 chr6:169726841 A/T cg16388071 chr6:169726476 NA 0.48 7.61 0.39 2.9e-13 Obesity-related traits; CRC cis rs1218582 0.772 rs4845682 chr1:154877105 T/C cg09359103 chr1:154839909 KCNN3 -0.71 -12.5 -0.57 1.33e-29 Prostate cancer; CRC cis rs8070740 0.898 rs9303192 chr17:5324836 C/T cg25236894 chr17:5323110 RPAIN;NUP88 0.48 7.5 0.38 5.95e-13 Menopause (age at onset); CRC cis rs1580019 0.961 rs1868776 chr7:32494435 G/T cg07520158 chr7:32535189 LSM5;AVL9 -0.44 -6.34 -0.33 7.4e-10 Cognitive ability; CRC cis rs9611565 0.649 rs202645 chr22:41798520 A/G cg06481639 chr22:41940642 POLR3H 0.51 5.67 0.3 3.08e-8 Vitiligo; CRC cis rs7705042 0.865 rs9324866 chr5:141497650 A/G cg08523384 chr5:141488047 NDFIP1 -0.33 -5.85 -0.31 1.18e-8 Asthma; CRC cis rs9303401 0.659 rs12150264 chr17:56939927 G/A cg10487724 chr17:56770010 TEX14;RAD51C 0.76 9.51 0.46 4.05e-19 Cognitive test performance; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg23690033 chr15:37393574 MEIS2 0.43 6.03 0.32 4.44e-9 Anxiety disorder; CRC cis rs2522056 1.000 rs2057655 chr5:131807624 A/G cg24060327 chr5:131705240 SLC22A5 -0.42 -5.98 -0.31 5.67e-9 Lymphocyte counts;Fibrinogen; CRC cis rs11122272 0.735 rs2474630 chr1:231535335 G/A cg06096015 chr1:231504339 EGLN1 0.41 6.15 0.32 2.29e-9 Hemoglobin concentration; CRC cis rs7113874 0.569 rs4418812 chr11:8612000 A/G cg20771178 chr11:8615675 STK33 0.35 5.7 0.3 2.73e-8 Body mass index in physically active individuals;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs55665837 1.000 rs11023229 chr11:14461001 G/C cg19336497 chr11:14380999 RRAS2 -0.39 -6.64 -0.34 1.33e-10 Vitamin D levels; CRC cis rs9309473 0.632 rs6706179 chr2:73578577 C/T cg20560298 chr2:73613845 ALMS1 -0.48 -6.55 -0.34 2.24e-10 Metabolite levels; CRC cis rs6598955 0.724 rs7547520 chr1:26592310 C/T cg00852783 chr1:26633632 UBXN11 0.43 7.03 0.36 1.2e-11 Obesity-related traits; CRC cis rs9287719 0.967 rs3815521 chr2:10743654 G/C cg00105475 chr2:10696890 NA 0.45 7.3 0.37 2.19e-12 Prostate cancer; CRC cis rs1552244 0.935 rs7618815 chr3:10151045 A/G cg00166722 chr3:10149974 C3orf24 0.69 9.16 0.45 5.63e-18 Alzheimer's disease; CRC cis rs728616 1.000 rs728616 chr10:81847914 G/T cg05935833 chr10:81318306 SFTPA2 -0.56 -6.74 -0.35 7.13e-11 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs1448094 0.512 rs7299285 chr12:86244959 A/T cg02569458 chr12:86230093 RASSF9 0.42 7.2 0.37 4.01e-12 Major depressive disorder; CRC cis rs10504229 0.769 rs17215649 chr8:58152791 A/G cg21724239 chr8:58056113 NA 0.62 8.38 0.42 1.51e-15 Developmental language disorder (linguistic errors); CRC cis rs875971 0.862 rs4718377 chr7:66049678 C/T cg11764359 chr7:65958608 NA -0.59 -8.88 -0.44 4.53e-17 Aortic root size; CRC cis rs9905704 0.836 rs302875 chr17:56767874 A/G cg12560992 chr17:57184187 TRIM37 -0.55 -7.7 -0.39 1.64e-13 Testicular germ cell tumor; CRC cis rs1223397 0.651 rs59639740 chr6:13310895 T/G cg07912922 chr6:13274314 PHACTR1 0.38 6.0 0.31 5.21e-9 Blood pressure; CRC cis rs727505 0.954 rs67870530 chr7:124591878 A/G cg23710748 chr7:124431027 NA -0.82 -14.01 -0.61 2.7e-35 Lewy body disease; CRC cis rs7119 0.717 rs12901100 chr15:77815558 T/A cg10437265 chr15:77819839 NA 0.7 12.76 0.58 1.43e-30 Type 2 diabetes; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg15203618 chr11:85646125 NA -0.38 -6.12 -0.32 2.62e-9 Liver disease severity in Alagille syndrome; CRC cis rs1355223 0.545 rs12278318 chr11:34876507 C/G cg11058730 chr11:34937778 PDHX;APIP -0.43 -6.07 -0.32 3.51e-9 Systemic lupus erythematosus and Systemic sclerosis; CRC cis rs6952808 0.792 rs13224989 chr7:1953766 C/G cg20295408 chr7:1910781 MAD1L1 -0.41 -5.87 -0.31 1.05e-8 Bipolar disorder and schizophrenia; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg20588892 chr5:87565114 TMEM161B 0.44 6.17 0.32 2.06e-9 Response to antipsychotic treatment; CRC cis rs7666738 0.830 rs1534318 chr4:98965058 C/T cg05340658 chr4:99064831 C4orf37 0.58 8.86 0.44 5.16e-17 Colonoscopy-negative controls vs population controls; CRC cis rs561341 0.941 rs2428336 chr17:30290577 T/C cg12193833 chr17:30244370 NA -0.63 -8.02 -0.4 1.91e-14 Hip circumference adjusted for BMI; CRC cis rs11997175 0.902 rs7462140 chr8:33717880 A/G ch.8.33884649F chr8:33765107 NA 0.41 6.02 0.31 4.73e-9 Body mass index; CRC cis rs344364 0.511 rs911391 chr16:1947016 C/A cg09830162 chr16:1889614 FAHD1;C16orf73 -0.76 -9.19 -0.45 4.44e-18 Glomerular filtration rate in chronic kidney disease; CRC cis rs2797160 1.000 rs1832938 chr6:125988964 G/C cg05901451 chr6:126070800 HEY2 -0.38 -5.82 -0.31 1.36e-8 Endometrial cancer; CRC cis rs950169 0.800 rs34302901 chr15:85110943 C/G cg24253500 chr15:84953950 NA 0.36 6.3 0.33 9.47e-10 Schizophrenia; CRC cis rs10751667 0.961 rs7943115 chr11:973885 T/C cg23136738 chr11:925521 AP2A2 -0.51 -8.29 -0.42 2.96e-15 Alzheimer's disease (late onset); CRC cis rs2011503 1.000 rs8110250 chr19:19559989 G/A cg11584989 chr19:19387371 SF4 0.53 5.96 0.31 6.67e-9 Bipolar disorder; CRC cis rs6662572 0.950 rs11579176 chr1:46050561 G/T cg08644498 chr1:46502608 NA 0.49 7.04 0.36 1.12e-11 Blood protein levels; CRC cis rs11971779 0.590 rs6944104 chr7:139051120 T/A cg07862535 chr7:139043722 LUC7L2 0.57 7.35 0.38 1.61e-12 Diisocyanate-induced asthma; CRC cis rs6570726 0.791 rs6914203 chr6:145899975 C/A cg13319975 chr6:146136371 FBXO30 -0.39 -5.81 -0.31 1.48e-8 Lobe attachment (rater-scored or self-reported); CRC cis rs832540 0.931 rs331499 chr5:56210923 C/T cg24531977 chr5:56204891 C5orf35 -0.49 -7.44 -0.38 8.64e-13 Coronary artery disease; CRC cis rs11212617 0.967 rs227086 chr11:108244251 A/T cg12106634 chr11:108092400 ATM;NPAT 0.44 6.55 0.34 2.19e-10 Response to metformin in type 2 diabetes (glycemic); CRC trans rs4263408 0.934 rs9683743 chr4:39703194 A/C cg16304302 chr12:27486485 ARNTL2 -0.41 -6.11 -0.32 2.84e-9 Plasma amyloid beta peptide concentrations (ABx-40); CRC cis rs743757 1.000 rs2236964 chr3:50449062 C/G cg09545109 chr3:50388910 TUSC4;CYB561D2 -0.43 -6.25 -0.33 1.26e-9 Diastolic blood pressure; CRC cis rs4423214 1.000 rs12278461 chr11:71182185 C/T cg05163923 chr11:71159392 DHCR7 0.66 9.36 0.46 1.29e-18 Vitamin D levels; CRC cis rs10512697 1.000 rs17687944 chr5:3559290 A/G cg19473799 chr5:3511975 NA -0.73 -5.69 -0.3 2.77e-8 Immune response to smallpox vaccine (IL-6); CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg09844983 chr1:28240714 RPA2 -0.51 -6.16 -0.32 2.08e-9 Diisocyanate-induced asthma; CRC cis rs4481887 0.741 rs6682957 chr1:248535639 T/G cg00666640 chr1:248458726 OR2T12 0.43 7.64 0.39 2.42e-13 Common traits (Other); CRC cis rs1395 0.744 rs3739092 chr2:27462076 C/T cg14242246 chr2:27434262 C2orf28;SLC5A6 0.42 7.82 0.4 7.25e-14 Blood metabolite levels; CRC cis rs1799949 0.965 rs799917 chr17:41244936 G/A cg25072359 chr17:41440525 NA 0.51 8.12 0.41 9.26e-15 Menopause (age at onset); CRC cis rs10504229 1.000 rs57186557 chr8:58177277 A/G cg02290350 chr8:58132656 NA -0.42 -5.96 -0.31 6.62e-9 Developmental language disorder (linguistic errors); CRC cis rs7412746 0.658 rs6677420 chr1:150946490 G/A cg18016565 chr1:150552671 MCL1 0.43 5.91 0.31 8.66e-9 Melanoma; CRC cis rs7707921 1.000 rs79616997 chr5:81504600 G/T cg17942617 chr5:81327376 ATG10 0.4 6.05 0.32 4.04e-9 Breast cancer; CRC cis rs561341 1.000 rs72823787 chr17:30283809 A/T cg23018236 chr17:30244563 NA -0.65 -7.74 -0.39 1.21e-13 Hip circumference adjusted for BMI; CRC cis rs7107174 1.000 rs2511170 chr11:77980582 A/G cg02023728 chr11:77925099 USP35 0.55 8.36 0.42 1.75e-15 Testicular germ cell tumor; CRC cis rs12220238 1.000 rs7904207 chr10:75884474 A/T cg19889307 chr10:75911429 ADK;AP3M1 0.62 6.25 0.33 1.31e-9 Soluble interleukin-2 receptor subunit alpha; CRC cis rs4561483 0.667 rs3743590 chr16:11930337 A/C cg08843971 chr16:11963173 GSPT1 -0.39 -5.89 -0.31 9.62e-9 Testicular germ cell tumor; CRC cis rs977987 0.806 rs11644306 chr16:75490053 T/C cg03315344 chr16:75512273 CHST6 0.53 9.04 0.45 1.35e-17 Dupuytren's disease; CRC cis rs735396 0.595 rs2258287 chr12:121454313 G/T cg02403541 chr12:121454288 C12orf43 0.59 9.23 0.45 3.45e-18 N-glycan levels; CRC cis rs7408868 1.000 rs7247835 chr19:15262844 A/G cg14696996 chr19:15285081 NOTCH3 0.93 8.47 0.42 8.27e-16 Pulse pressure; CRC cis rs3996993 0.772 rs3957356 chr6:52668670 T/C cg20803780 chr6:52668592 GSTA1 -0.38 -7.01 -0.36 1.38e-11 Hemoglobin concentration; CRC cis rs6502050 0.835 rs6502065 chr17:80095642 T/C cg22110888 chr17:80059540 CCDC57 0.4 6.44 0.33 4.17e-10 Life satisfaction; CRC trans rs10060123 1.000 rs10072241 chr5:125685150 C/T ch.6.113866684R chr6:113759991 NA -0.37 -5.99 -0.31 5.61e-9 Visceral adipose tissue adjusted for BMI;Visceral adipose tissue; CRC cis rs10089 1.000 rs2054444 chr5:127493206 A/C cg25462716 chr5:127418816 SLC12A2;FLJ33630 -0.67 -8.78 -0.44 8.78e-17 Ileal carcinoids; CRC trans rs1945213 0.625 rs7128190 chr11:55858550 A/T cg15704280 chr7:45808275 SEPT13 0.56 6.27 0.33 1.15e-9 Acute lymphoblastic leukemia (childhood); CRC cis rs7772486 0.686 rs702314 chr6:146003510 G/A cg13319975 chr6:146136371 FBXO30 0.41 6.15 0.32 2.21e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs372883 0.648 rs1003772 chr21:30736145 A/T cg24692254 chr21:30365293 RNF160 0.64 9.69 0.47 1.05e-19 Pancreatic cancer; CRC cis rs7568458 0.684 rs7608074 chr2:85809703 T/G cg02493740 chr2:85810744 VAMP5 -0.54 -8.2 -0.41 5.35e-15 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); CRC cis rs10504229 0.683 rs16921823 chr8:58108612 G/C cg02725872 chr8:58115012 NA -0.66 -11.36 -0.53 1.84e-25 Developmental language disorder (linguistic errors); CRC cis rs7173389 0.551 rs74022957 chr15:73663239 G/A cg01796676 chr15:73680284 NA 0.58 5.88 0.31 9.96e-9 Resting heart rate; CRC cis rs2290405 0.593 rs12499663 chr4:888170 G/A cg23939001 chr4:940644 TMEM175 0.37 6.43 0.33 4.43e-10 Systemic sclerosis; CRC cis rs6120849 0.901 rs6060266 chr20:33733078 T/C cg24642439 chr20:33292090 TP53INP2 0.44 5.77 0.3 1.87e-8 Protein C levels; CRC cis rs11864453 0.560 rs6499561 chr16:72148404 A/G cg01557791 chr16:72042693 DHODH -0.43 -6.18 -0.32 1.95e-9 Fibrinogen levels; CRC cis rs561341 0.883 rs72821942 chr17:30234460 C/T cg13647721 chr17:30228624 UTP6 0.59 5.9 0.31 9.1e-9 Hip circumference adjusted for BMI; CRC cis rs1609391 0.543 rs2117009 chr3:136633571 A/T cg15507776 chr3:136538369 TMEM22 -0.34 -6.18 -0.32 1.92e-9 Neuroticism; CRC cis rs8044995 0.563 rs3743743 chr16:68397775 C/T cg09835421 chr16:68378352 PRMT7 -0.81 -8.27 -0.41 3.44e-15 Schizophrenia; CRC cis rs9303401 0.659 rs12944971 chr17:56988801 A/T cg10487724 chr17:56770010 TEX14;RAD51C 0.77 9.05 0.45 1.25e-17 Cognitive test performance; CRC cis rs9420 0.961 rs79260745 chr11:57612960 T/C cg23127183 chr11:57508653 C11orf31 -0.53 -7.11 -0.36 7.39e-12 Schizophrenia; CRC cis rs9916302 0.821 rs412430 chr17:37737094 C/G cg03013999 chr17:37608204 MED1 0.48 7.2 0.37 4.02e-12 Glomerular filtration rate (creatinine); CRC cis rs3733585 0.773 rs13107466 chr4:10019390 G/A cg00071950 chr4:10020882 SLC2A9 0.68 13.33 0.59 1.07e-32 Cleft plate (environmental tobacco smoke interaction); CRC trans rs1387259 0.839 rs7487682 chr12:48579665 A/C cg00419564 chr1:153508860 S100A6 -0.47 -6.31 -0.33 8.99e-10 Obstructive sleep apnea trait (apnea hypopnea index); CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg16189954 chr22:29138267 HSCB;CHEK2 0.47 6.32 0.33 8.44e-10 Thyroid stimulating hormone; CRC cis rs992157 0.764 rs13020391 chr2:219184436 C/T cg04880052 chr2:219191631 PNKD -0.45 -6.66 -0.34 1.18e-10 Colorectal cancer; CRC cis rs9393777 0.778 rs74689501 chr6:26887821 G/A cg16898833 chr6:26189333 HIST1H4D 0.85 6.28 0.33 1.06e-9 Intelligence (multi-trait analysis); CRC cis rs79349575 0.749 rs12601672 chr17:47006493 T/C cg22482690 chr17:47019901 SNF8 0.47 7.94 0.4 3.2e-14 Type 2 diabetes; CRC trans rs61931739 0.500 rs11053278 chr12:34555955 T/C cg26384229 chr12:38710491 ALG10B 0.6 8.84 0.44 5.75e-17 Morning vs. evening chronotype; CRC cis rs2735413 0.918 rs11646244 chr16:78082453 T/C cg04733911 chr16:78082701 NA -0.45 -7.41 -0.38 1.11e-12 Systolic blood pressure (alcohol consumption interaction); CRC cis rs6121246 0.559 rs6060944 chr20:30372114 G/A cg13852791 chr20:30311386 BCL2L1 0.78 15.32 0.65 2.24e-40 Mean corpuscular hemoglobin; CRC cis rs10751667 0.666 rs7394427 chr11:970405 G/A cg23136738 chr11:925521 AP2A2 -0.42 -7.09 -0.36 8.19e-12 Alzheimer's disease (late onset); CRC cis rs10464366 0.544 rs6952466 chr7:39155032 A/T cg15212455 chr7:39170539 POU6F2 0.49 6.58 0.34 1.89e-10 IgG glycosylation; CRC cis rs870825 1.000 rs870823 chr4:185588195 G/A cg07424746 chr4:185654737 MLF1IP -0.65 -6.07 -0.32 3.44e-9 Blood protein levels; CRC cis rs4819052 0.851 rs7279011 chr21:46655995 G/A cg19498844 chr21:46707878 POFUT2;LOC642852 0.73 10.1 0.49 4.42e-21 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs6952808 0.689 rs12670737 chr7:2046830 C/T cg18279126 chr7:2041391 MAD1L1 0.45 6.81 0.35 4.73e-11 Bipolar disorder and schizophrenia; CRC cis rs10540 0.841 rs35601764 chr11:532923 A/C cg03576123 chr11:487126 PTDSS2 -1.0 -10.1 -0.49 4.63e-21 Body mass index; CRC cis rs728616 0.614 rs61859199 chr10:82118613 G/T cg05935833 chr10:81318306 SFTPA2 -0.58 -7.02 -0.36 1.28e-11 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs362272 0.524 rs13150241 chr4:3367281 A/G cg01612440 chr4:3296283 NA 0.43 6.1 0.32 3.06e-9 Serum sulfate level; CRC cis rs12824058 0.831 rs11616174 chr12:130814503 A/G cg26677194 chr12:130822605 PIWIL1 0.44 7.23 0.37 3.4e-12 Menopause (age at onset); CRC cis rs17666538 0.585 rs1703927 chr8:613620 A/G cg13264159 chr8:625131 ERICH1 0.62 6.1 0.32 3e-9 IgG glycosylation; CRC cis rs4253772 0.515 rs74766656 chr22:46662497 A/G cg24881330 chr22:46731750 TRMU 0.65 6.29 0.33 1.02e-9 LDL cholesterol;Cholesterol, total; CRC cis rs9443645 0.901 rs1542977 chr6:79550307 G/T cg05283184 chr6:79620031 NA -0.57 -9.14 -0.45 6.8e-18 Intelligence (multi-trait analysis); CRC trans rs7976838 0.908 rs61933776 chr12:60118939 G/A cg16974014 chr22:22007515 MIR130B 0.49 6.02 0.31 4.62e-9 Response to zileuton treatment in asthma (FEV1 change interaction); CRC cis rs6952808 0.531 rs3778998 chr7:2180753 C/A cg04267008 chr7:1944627 MAD1L1 -0.55 -7.61 -0.39 2.87e-13 Bipolar disorder and schizophrenia; CRC cis rs7259376 0.777 rs2664067 chr19:22638066 C/T cg02657401 chr19:22469223 NA -0.36 -7.68 -0.39 1.89e-13 Menopause (age at onset); CRC cis rs11711311 1.000 rs1073040 chr3:113522123 C/G cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.54 -7.34 -0.37 1.73e-12 IgG glycosylation; CRC cis rs10504229 0.683 rs67077711 chr8:58139769 G/T cg02725872 chr8:58115012 NA -0.64 -11.55 -0.54 3.85e-26 Developmental language disorder (linguistic errors); CRC cis rs17095355 1.000 rs11194926 chr10:111700922 A/G cg00817464 chr10:111662876 XPNPEP1 0.62 8.14 0.41 8.08e-15 Biliary atresia; CRC trans rs17607347 0.738 rs7198449 chr16:72389230 C/T cg27230510 chr3:50404023 CACNA2D2 0.53 6.04 0.32 4.23e-9 Intelligence (multi-trait analysis); CRC cis rs2576037 0.526 rs998819 chr18:44564181 C/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 -0.53 -8.44 -0.42 1.04e-15 Personality dimensions; CRC cis rs1322512 1.000 rs2800633 chr6:153010308 T/G cg03415253 chr6:152958462 SYNE1 0.4 6.04 0.32 4.14e-9 Tonometry; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg01298356 chr11:64889837 FAU;MRPL49 0.42 6.16 0.32 2.13e-9 Intelligence (multi-trait analysis); CRC trans rs7615952 0.546 rs112919177 chr3:125346070 G/A cg02007433 chr3:129722099 NA -0.51 -6.26 -0.33 1.19e-9 Blood pressure (smoking interaction); CRC cis rs2404602 0.583 rs12898415 chr15:76574232 C/T cg26408565 chr15:76604113 ETFA -0.38 -6.01 -0.31 4.83e-9 Blood metabolite levels; CRC cis rs11645898 0.687 rs1424241 chr16:72078907 G/A cg14768367 chr16:72042858 DHODH -0.52 -6.09 -0.32 3.15e-9 Blood protein levels; CRC cis rs4604732 0.588 rs74154678 chr1:247626202 A/T cg12754571 chr1:247694271 LOC148824;OR2C3 0.41 5.75 0.3 2.04e-8 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CRC cis rs4319547 0.695 rs10846746 chr12:122868696 C/T cg23029597 chr12:123009494 RSRC2 0.58 7.04 0.36 1.16e-11 Body mass index; CRC cis rs929354 0.772 rs2366214 chr7:156992461 A/G cg05182265 chr7:156933206 UBE3C -0.76 -14.51 -0.62 3.13e-37 Body mass index; CRC cis rs6089584 0.830 rs4925331 chr20:60580174 T/C cg13770153 chr20:60521292 NA -0.55 -9.14 -0.45 6.38e-18 Body mass index; CRC cis rs1003719 0.715 rs7280251 chr21:38567911 T/C cg10648535 chr21:38446584 PIGP;TTC3 -0.45 -6.29 -0.33 9.85e-10 Eye color traits; CRC cis rs3820068 0.559 rs6675334 chr1:15923580 A/T cg24675056 chr1:15929824 NA 0.52 7.14 0.37 6.18e-12 Systolic blood pressure; CRC cis rs7043114 0.525 rs2274966 chr9:95155563 C/A cg14631576 chr9:95140430 CENPP -0.31 -5.9 -0.31 8.88e-9 Height; CRC cis rs875971 0.862 rs6460302 chr7:65960257 C/G cg11764359 chr7:65958608 NA 0.61 9.56 0.47 2.94e-19 Aortic root size; CRC cis rs736408 0.812 rs1075653 chr3:52825528 T/C cg08222913 chr3:52553049 STAB1 -0.34 -6.01 -0.31 5.01e-9 Bipolar disorder; CRC cis rs477692 1.000 rs477692 chr10:131426022 T/C cg05714579 chr10:131428358 MGMT 0.57 8.35 0.42 1.87e-15 Response to temozolomide; CRC cis rs7193541 0.684 rs4888262 chr16:74670458 C/T cg01733217 chr16:74700730 RFWD3 1.05 21.82 0.77 6.85e-66 Multiple myeloma; CRC trans rs10403021 1.000 rs10406970 chr19:30076221 A/G cg22044635 chr17:76557109 DNAH17 0.45 6.09 0.32 3.22e-9 Diabetic retinopathy; CRC cis rs6963495 0.818 rs56268110 chr7:105166712 T/C cg02135003 chr7:105160482 PUS7 -0.91 -12.41 -0.56 2.87e-29 Bipolar disorder (body mass index interaction); CRC cis rs6723226 0.750 rs3769597 chr2:32691400 T/G cg02381751 chr2:32503542 YIPF4 0.51 7.37 0.38 1.36e-12 Intelligence (multi-trait analysis); CRC cis rs3807766 0.581 rs6954104 chr7:77693258 C/T cg24315188 chr7:77428849 PHTF2;TMEM60 -0.42 -5.84 -0.31 1.25e-8 3-hydroxypropylmercapturic acid levels in smokers; CRC cis rs7089973 0.604 rs11196939 chr10:116593175 A/G cg23260525 chr10:116636907 FAM160B1 -0.34 -7.78 -0.39 9.3e-14 Bipolar disorder or attention deficit hyperactivity disorder; CRC cis rs9303280 0.806 rs11870965 chr17:38030205 T/A cg11212589 chr17:38028394 ZPBP2 0.43 7.97 0.4 2.71e-14 Self-reported allergy; CRC cis rs11252926 0.537 rs4554800 chr10:458477 G/T cg03684893 chr10:554711 DIP2C 0.32 5.64 0.3 3.65e-8 Psychosis in Alzheimer's disease; CRC trans rs7819412 0.668 rs2409715 chr8:11010136 A/T cg06636001 chr8:8085503 FLJ10661 -0.44 -6.64 -0.34 1.33e-10 Triglycerides; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg13265914 chr8:21999630 REEP4 0.5 6.75 0.35 6.5e-11 Thyroid stimulating hormone; CRC cis rs4713118 0.513 rs149989 chr6:27998184 T/A cg06470822 chr6:28175283 NA 0.8 12.28 0.56 8.36e-29 Parkinson's disease; CRC cis rs3772130 1.000 rs11714406 chr3:121372513 C/T cg20356878 chr3:121714668 ILDR1 0.49 7.58 0.39 3.64e-13 Cognitive performance; CRC cis rs2836950 0.520 rs11911087 chr21:40665192 G/A cg11890956 chr21:40555474 PSMG1 -0.63 -9.3 -0.46 1.96e-18 Menarche (age at onset); CRC cis rs9462846 1.000 rs2395941 chr6:42867821 G/A cg21280719 chr6:42927975 GNMT -0.34 -5.89 -0.31 9.44e-9 Blood protein levels; CRC cis rs4808199 0.895 rs7252888 chr19:19628037 C/T cg03709012 chr19:19516395 GATAD2A 0.95 11.63 0.54 2e-26 Nonalcoholic fatty liver disease; CRC cis rs11758351 0.660 rs56398712 chr6:26213868 A/G cg01420254 chr6:26195488 NA 0.77 8.6 0.43 3.3e-16 Gout;Renal underexcretion gout; CRC cis rs9649465 1.000 rs9641715 chr7:123348623 A/G cg03229431 chr7:123269106 ASB15 -0.36 -5.62 -0.3 4.05e-8 Migraine; CRC cis rs7584330 0.554 rs7582964 chr2:238385766 C/T cg16989719 chr2:238392110 NA 0.46 6.97 0.36 1.71e-11 Prostate cancer; CRC cis rs7618915 0.501 rs2159644 chr3:52774530 C/T cg11645453 chr3:52864694 ITIH4 0.36 6.48 0.34 3.31e-10 Bipolar disorder; CRC cis rs4074493 1.000 rs6700792 chr1:231170013 C/T cg22172038 chr1:231176991 FAM89A -0.34 -5.88 -0.31 9.87e-9 Carotid plaque burden (smoking interaction); CRC cis rs6570726 0.791 rs13202312 chr6:145913093 T/G cg23711669 chr6:146136114 FBXO30 0.75 12.89 0.58 4.75e-31 Lobe attachment (rater-scored or self-reported); CRC cis rs12477438 0.765 rs7605734 chr2:99644068 G/A cg14399236 chr2:99771627 LIPT1;TSGA10 -0.6 -8.2 -0.41 5.41e-15 Chronic sinus infection; CRC cis rs72945132 0.882 rs67822447 chr11:70230972 G/T cg00319359 chr11:70116639 PPFIA1 0.56 5.84 0.31 1.27e-8 Coronary artery disease; CRC cis rs9322193 0.851 rs9322194 chr6:149920249 C/T cg00933542 chr6:150070202 PCMT1 0.32 6.49 0.34 3.07e-10 Lung cancer; CRC cis rs2239547 0.563 rs4687560 chr3:52898121 T/G cg18404041 chr3:52824283 ITIH1 -0.4 -7.38 -0.38 1.27e-12 Schizophrenia; CRC trans rs1656966 1.000 rs1656966 chr3:186466252 C/T cg24167897 chr15:63796719 USP3 0.4 6.33 0.33 7.97e-10 Myopia (pathological); CRC cis rs7558233 0.614 rs4665213 chr2:23678781 A/G cg00747342 chr2:23700632 KLHL29 0.53 5.93 0.31 7.87e-9 Cannabis use (initiation); CRC cis rs802075 0.658 rs11757820 chr6:49636941 A/C cg20364632 chr6:49636226 NA 0.36 6.22 0.32 1.48e-9 Bone mineral density (hip) and age at menarche; CRC trans rs10504229 1.000 rs66936919 chr8:58172868 C/G cg04077850 chr5:125800366 GRAMD3 0.36 6.13 0.32 2.47e-9 Developmental language disorder (linguistic errors); CRC trans rs2228479 0.850 rs17232630 chr16:89851179 C/T cg24644049 chr4:85504048 CDS1 0.92 7.64 0.39 2.42e-13 Skin colour saturation; CRC trans rs2303319 0.504 rs55638078 chr2:162524997 T/C cg14875682 chr5:52083620 ITGA1;PELO -0.76 -6.16 -0.32 2.13e-9 Cognitive function; CRC cis rs754466 0.580 rs10824577 chr10:79577408 G/C cg26805224 chr10:79626177 DLG5 -0.49 -7.29 -0.37 2.37e-12 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs6743226 1.000 rs6743226 chr2:242236972 T/C cg10021735 chr2:242295487 FARP2 0.46 6.53 0.34 2.5e-10 Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI in non-smokers; CRC cis rs4862750 0.872 rs7658314 chr4:187900356 T/C cg22105103 chr4:187893119 NA 0.64 11.71 0.54 1.01e-26 Lobe attachment (rater-scored or self-reported); CRC cis rs921968 0.528 rs13022583 chr2:219589175 T/C cg02176678 chr2:219576539 TTLL4 -0.39 -6.3 -0.33 9.48e-10 Mean corpuscular hemoglobin concentration; CRC cis rs2243480 1.000 rs160639 chr7:65579987 C/G cg18252515 chr7:66147081 NA -1.18 -13.88 -0.61 8.21e-35 Diabetic kidney disease; CRC cis rs12451471 0.500 rs8077056 chr17:78076006 C/T cg24585782 chr17:78113791 EIF4A3 -0.53 -7.36 -0.38 1.44e-12 Plateletcrit;Mean corpuscular hemoglobin concentration; CRC cis rs6951245 1.000 rs79617366 chr7:1111958 G/C cg24642844 chr7:1081250 C7orf50 -0.78 -9.34 -0.46 1.47e-18 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs13108904 0.967 rs11247987 chr4:1294532 G/A cg16405210 chr4:1374714 KIAA1530 -0.44 -5.96 -0.31 6.46e-9 Obesity-related traits; CRC cis rs2976388 0.578 rs3736010 chr8:143817503 T/C cg10596483 chr8:143751796 JRK -0.5 -6.82 -0.35 4.5e-11 Urinary tract infection frequency; CRC cis rs2976388 0.609 rs2585152 chr8:143786214 A/T cg20041105 chr8:143859282 LYNX1 0.46 8.18 0.41 6.24e-15 Urinary tract infection frequency; CRC cis rs35146811 0.807 rs6953441 chr7:99617067 G/A cg13334819 chr7:99746414 C7orf59 -0.58 -7.96 -0.4 2.88e-14 Coronary artery disease; CRC cis rs2290405 0.527 rs7663192 chr4:923947 T/C cg09237302 chr4:906077 GAK -0.47 -8.35 -0.42 1.87e-15 Systemic sclerosis; CRC cis rs669446 0.562 rs6429636 chr1:44183540 G/T cg12908607 chr1:44402522 ARTN -0.33 -5.63 -0.3 3.94e-8 Amyotrophic lateral sclerosis (age of onset); CRC cis rs4474465 1.000 rs10899514 chr11:78172695 A/G cg27205649 chr11:78285834 NARS2 -0.46 -5.66 -0.3 3.26e-8 Alzheimer's disease (survival time); CRC cis rs4803468 0.905 rs284662 chr19:41932275 T/C cg09537434 chr19:41945824 ATP5SL -0.97 -17.81 -0.7 3.71e-50 Height; CRC cis rs6741819 0.740 rs771263 chr2:7128967 A/G cg27144453 chr2:7172511 RNF144A -0.41 -5.98 -0.31 5.73e-9 Response to antipsychotic treatment; CRC cis rs6964587 1.000 rs2282968 chr7:91580287 A/C cg17063962 chr7:91808500 NA -0.76 -12.36 -0.56 4.23e-29 Breast cancer; CRC cis rs9430161 0.579 rs7542354 chr1:11040385 G/A cg02454025 chr1:11042201 C1orf127 0.9 14.49 0.62 3.98e-37 Ewing sarcoma; CRC trans rs8073060 0.614 rs225275 chr17:33972567 G/C cg19694781 chr19:47549865 TMEM160 -1.05 -14.85 -0.63 1.57e-38 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; CRC cis rs1129187 0.755 rs9471982 chr6:42935998 G/A cg26304593 chr6:42947056 PEX6 -0.45 -6.54 -0.34 2.4e-10 Alzheimer's disease in APOE e4+ carriers; CRC cis rs2050392 0.590 rs2065723 chr10:30720462 A/T cg18806716 chr10:30721971 MAP3K8 -0.7 -10.18 -0.49 2.39e-21 Inflammatory bowel disease; CRC cis rs863345 0.565 rs10908668 chr1:158501933 C/T cg12129480 chr1:158549410 OR10X1 -0.3 -6.27 -0.33 1.12e-9 Pneumococcal bacteremia; CRC cis rs10242455 0.702 rs76702117 chr7:98916779 A/G cg18809830 chr7:99032528 PTCD1 -1.01 -6.97 -0.36 1.72e-11 Blood metabolite levels; CRC cis rs9467711 0.606 rs9358937 chr6:26374274 C/G cg14345882 chr6:26364793 BTN3A2 0.64 5.63 0.3 3.85e-8 Autism spectrum disorder or schizophrenia; CRC cis rs370915 0.542 rs7687552 chr4:187837862 G/C cg19519643 chr4:187840862 NA -0.65 -11.15 -0.52 1.01e-24 Gout; CRC cis rs35883536 1.000 rs2297712 chr1:101092813 C/T cg14515779 chr1:101123966 NA -0.43 -8.39 -0.42 1.49e-15 Monocyte count; CRC cis rs477692 0.967 rs519690 chr10:131424033 G/A cg05714579 chr10:131428358 MGMT 0.55 8.13 0.41 8.74e-15 Response to temozolomide; CRC cis rs11711311 1.000 rs10212375 chr3:113471336 G/A cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.51 -6.92 -0.36 2.31e-11 IgG glycosylation; CRC cis rs17401966 0.931 rs12408430 chr1:10323339 T/A cg19773385 chr1:10388646 KIF1B -0.7 -11.51 -0.54 5.51e-26 Hepatocellular carcinoma; CRC cis rs11622475 1.000 rs2273610 chr14:104387642 G/C cg20488157 chr14:104394430 TDRD9 0.68 9.55 0.47 3e-19 Bipolar disorder; CRC cis rs2013441 1.000 rs17759959 chr17:20024095 A/G cg13482628 chr17:19912719 NA 0.41 6.32 0.33 8.47e-10 Obesity-related traits; CRC cis rs4819052 0.851 rs2255766 chr21:46683777 C/T cg11663144 chr21:46675770 NA -0.83 -14.21 -0.62 4.78e-36 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs804280 0.565 rs1466785 chr8:11623456 C/T cg12395012 chr8:11607386 GATA4 -0.4 -6.56 -0.34 2.07e-10 Myopia (pathological); CRC cis rs10504229 0.679 rs17804870 chr8:58158071 A/G cg22535103 chr8:58192502 C8orf71 -0.84 -8.9 -0.44 3.72e-17 Developmental language disorder (linguistic errors); CRC cis rs1568889 1.000 rs7945367 chr11:28166272 G/T cg06544937 chr11:28130018 METT5D1;KIF18A 0.81 11.55 0.54 3.84e-26 Bipolar disorder; CRC cis rs2380220 0.576 rs4498363 chr6:96042338 A/C cg23517279 chr6:96025343 MANEA 0.56 6.37 0.33 6.47e-10 Behavioural disinhibition (generation interaction); CRC cis rs4713118 0.539 rs510987 chr6:27847517 G/A cg08798685 chr6:27730294 NA -0.41 -5.91 -0.31 8.62e-9 Parkinson's disease; CRC cis rs6951245 1.000 rs78308415 chr7:1072634 G/A cg20603222 chr7:1096387 C7orf50;GPR146 -0.7 -8.17 -0.41 6.82e-15 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs7591163 1.000 rs6744308 chr2:228711816 T/G cg08034379 chr2:228736324 WDR69 -0.53 -7.22 -0.37 3.59e-12 Blood pressure; CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg11355319 chr5:89825117 LYSMD3 -0.51 -6.2 -0.32 1.68e-9 Diisocyanate-induced asthma; CRC cis rs1801251 1.000 rs4517962 chr2:233578337 T/C cg25237894 chr2:233734115 C2orf82 0.49 7.99 0.4 2.31e-14 Coronary artery disease; CRC cis rs6565180 0.926 rs4787643 chr16:30393660 G/A cg01392867 chr16:30410429 ZNF48 0.38 6.1 0.32 3e-9 Tonsillectomy; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg26035323 chr1:44871156 RNF220 0.37 6.18 0.32 1.92e-9 Liver disease severity in Alagille syndrome; CRC cis rs1045714 0.895 rs4719602 chr7:2647800 G/A cg24848437 chr7:2645542 IQCE 0.61 6.33 0.33 8.03e-10 Urate levels in lean individuals; CRC cis rs599083 0.530 rs640569 chr11:68184820 A/G cg16797656 chr11:68205561 LRP5 -0.41 -6.45 -0.33 4.04e-10 Bone mineral density (spine); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg08017156 chr16:21611107 METTL9 0.42 5.99 0.31 5.38e-9 Intelligence (multi-trait analysis); CRC cis rs9368481 0.594 rs7768814 chr6:26892036 C/A cg18278486 chr6:26987575 LOC100270746;C6orf41 0.38 5.97 0.31 5.99e-9 Autism spectrum disorder or schizophrenia; CRC cis rs3862030 0.694 rs12781742 chr10:104227469 G/A cg11453585 chr10:104263688 ACTR1A;SUFU -0.77 -13.41 -0.59 5.15e-33 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for body mass index; CRC cis rs875971 0.862 rs6955837 chr7:66043142 C/T cg18252515 chr7:66147081 NA 0.44 6.21 0.32 1.64e-9 Aortic root size; CRC cis rs10504229 0.520 rs55967509 chr8:57992448 A/G cg21724239 chr8:58056113 NA 0.57 7.36 0.38 1.52e-12 Developmental language disorder (linguistic errors); CRC cis rs4713118 0.662 rs464312 chr6:27967591 T/A cg06470822 chr6:28175283 NA 0.84 12.77 0.58 1.28e-30 Parkinson's disease; CRC cis rs8060686 0.920 rs73591961 chr16:67801309 G/A cg26727032 chr16:67993705 SLC12A4 -0.6 -6.97 -0.36 1.69e-11 HDL cholesterol;Metabolic syndrome; CRC cis rs3800461 0.544 rs6919434 chr6:34498923 C/T cg14254433 chr6:34482411 PACSIN1 -0.67 -6.48 -0.34 3.41e-10 Chronic lymphocytic leukemia; CRC cis rs11785400 0.731 rs4736363 chr8:143742112 C/A cg24634471 chr8:143751801 JRK 0.52 7.21 0.37 3.82e-12 Schizophrenia; CRC cis rs113835537 0.935 rs11550057 chr11:66392880 C/T cg22134325 chr11:66188745 NPAS4 0.37 6.11 0.32 2.86e-9 Airway imaging phenotypes; CRC cis rs4819052 0.635 rs2838808 chr21:46621106 A/G cg19498844 chr21:46707878 POFUT2;LOC642852 0.55 7.16 0.37 5.36e-12 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs13315871 0.858 rs9848825 chr3:58239001 A/G cg20936604 chr3:58311152 NA -0.67 -6.76 -0.35 6.41e-11 Cholesterol, total; CRC cis rs1005277 0.579 rs2749616 chr10:38510993 A/T cg00409905 chr10:38381863 ZNF37A -0.64 -10.5 -0.5 1.92e-22 Extrinsic epigenetic age acceleration; CRC cis rs2882667 0.858 rs2043271 chr5:138459108 A/G cg04439458 chr5:138467593 SIL1 -0.36 -6.04 -0.32 4.14e-9 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs597539 0.652 rs557625 chr11:68634722 G/A cg06028808 chr11:68637592 NA 0.41 6.67 0.35 1.07e-10 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs10870270 1.000 rs10870270 chr10:133754334 G/A cg08754478 chr10:133766260 PPP2R2D -0.68 -9.79 -0.47 4.95e-20 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; CRC cis rs9814567 1.000 rs6787371 chr3:134254991 A/G cg06541857 chr3:134203789 ANAPC13;CEP63 -0.4 -6.01 -0.31 4.95e-9 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs7197653 0.748 rs11350 chr16:68335392 A/G cg09835421 chr16:68378352 PRMT7 -0.7 -7.22 -0.37 3.67e-12 Magnesium levels; CRC cis rs8067545 0.750 rs4925072 chr17:19956899 C/T cg13482628 chr17:19912719 NA -0.37 -5.65 -0.3 3.4e-8 Schizophrenia; CRC cis rs2857891 0.695 rs2857884 chr11:6984879 C/G cg04053776 chr11:6947353 ZNF215 0.4 6.24 0.33 1.33e-9 Response to cytadine analogues (cytosine arabinoside); CRC cis rs4629180 0.593 rs6707517 chr2:102089878 C/T cg12464048 chr2:102091129 RFX8 -0.42 -6.09 -0.32 3.23e-9 Chronic rhinosinusitis with nasal polyps; CRC trans rs561341 0.882 rs111484028 chr17:30287701 G/A cg20587970 chr11:113659929 NA -1.18 -17.22 -0.69 7.98e-48 Hip circumference adjusted for BMI; CRC cis rs965469 0.779 rs6037581 chr20:3351595 C/T cg25506879 chr20:3388711 C20orf194 -0.37 -5.73 -0.3 2.26e-8 IFN-related cytopenia; CRC cis rs3858526 0.584 rs10734559 chr11:5861788 A/C cg26762873 chr11:5879799 OR52E8 -0.47 -7.09 -0.36 8.33e-12 DNA methylation (variation); CRC cis rs7909074 0.865 rs10900123 chr10:45376574 C/T cg04218760 chr10:45406644 TMEM72 -0.33 -9.65 -0.47 1.44e-19 Mean corpuscular volume; CRC cis rs11105298 0.891 rs4842653 chr12:89834113 C/T cg00757033 chr12:89920650 WDR51B 0.37 6.19 0.32 1.8e-9 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; CRC trans rs11098499 0.863 rs3775845 chr4:120432447 T/C cg25214090 chr10:38739885 LOC399744 0.63 9.85 0.48 3.24e-20 Corneal astigmatism; CRC cis rs4820294 1.000 rs62236665 chr22:38059847 C/A cg21798802 chr22:38057573 PDXP 0.47 7.34 0.37 1.73e-12 Fat distribution (HIV); CRC cis rs11758351 0.866 rs75091077 chr6:26207546 A/C cg10723962 chr6:26240782 HIST1H4F -0.38 -6.26 -0.33 1.22e-9 Gout;Renal underexcretion gout; CRC cis rs720844 0.748 rs35057193 chr2:149339255 A/G cg09247360 chr2:149335327 NA -0.57 -6.01 -0.31 5.03e-9 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs10450586 0.932 rs10450561 chr11:27309956 C/T cg10370305 chr11:27303972 NA -0.35 -5.69 -0.3 2.74e-8 Total body bone mineral density; CRC cis rs9733 0.596 rs11807058 chr1:150640475 G/A cg17724175 chr1:150552817 MCL1 0.58 9.4 0.46 9.25e-19 Tonsillectomy; CRC cis rs4713118 0.911 rs9295746 chr6:27730064 T/C cg20933634 chr6:27740509 NA 0.53 6.55 0.34 2.24e-10 Parkinson's disease; CRC cis rs6952808 0.692 rs56727870 chr7:2029940 T/C cg21782813 chr7:2030301 MAD1L1 0.54 9.44 0.46 7.29e-19 Bipolar disorder and schizophrenia; CRC cis rs853679 0.550 rs1225599 chr6:28165190 C/T cg12273811 chr6:28175739 NA 0.76 10.93 0.52 6.19e-24 Depression; CRC cis rs4481887 1.000 rs4244178 chr1:248468441 A/G cg00666640 chr1:248458726 OR2T12 0.54 9.44 0.46 7.02e-19 Common traits (Other); CRC cis rs2228479 0.850 rs3785279 chr16:89824562 G/C cg19635926 chr16:89946313 TCF25 0.63 5.68 0.3 3.01e-8 Skin colour saturation; CRC cis rs938554 0.692 rs4428284 chr4:9996392 A/T cg11266682 chr4:10021025 SLC2A9 0.4 6.04 0.32 4.17e-9 Blood metabolite levels; CRC cis rs6502050 0.835 rs4499294 chr17:80148346 C/T cg02741985 chr17:80059408 CCDC57 0.44 7.18 0.37 4.6e-12 Life satisfaction; CRC cis rs28386778 0.897 rs8069969 chr17:61822223 T/G cg07362569 chr17:61921086 SMARCD2 0.37 5.71 0.3 2.58e-8 Prudent dietary pattern; CRC cis rs6088580 0.634 rs6059867 chr20:33078103 C/T cg08999081 chr20:33150536 PIGU 0.62 11.34 0.53 2.26e-25 Glomerular filtration rate (creatinine); CRC cis rs13191362 0.935 rs116735807 chr6:163010615 A/G cg21926612 chr6:163149169 PACRG;PARK2 0.79 10.93 0.52 6.15e-24 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs10870270 1.000 rs11146354 chr10:133774757 A/G cg17892150 chr10:133769511 PPP2R2D -0.74 -10.85 -0.51 1.23e-23 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; CRC cis rs644148 0.902 rs12982159 chr19:44964300 C/T cg15540054 chr19:45004280 ZNF180 -0.66 -9.27 -0.46 2.51e-18 Personality dimensions; CRC cis rs908922 0.676 rs4845782 chr1:152492225 A/G cg09873164 chr1:152488093 CRCT1 0.37 6.15 0.32 2.19e-9 Hair morphology; CRC cis rs1267303 0.642 rs11588450 chr1:47000996 C/T cg25110126 chr1:46999211 NA -0.54 -8.44 -0.42 1.04e-15 Monobrow; CRC cis rs7586673 1.000 rs16845584 chr2:161923830 C/T cg22496339 chr2:162101262 NA -0.55 -7.84 -0.4 6.16e-14 Intelligence (multi-trait analysis); CRC cis rs7617773 0.514 rs11130166 chr3:48388056 A/G cg11946769 chr3:48343235 NME6 0.61 8.38 0.42 1.54e-15 Coronary artery disease; CRC cis rs950880 0.593 rs887972 chr2:103040945 G/A cg03938978 chr2:103052716 IL18RAP -0.41 -5.67 -0.3 3.16e-8 Serum protein levels (sST2); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg02850371 chr1:244999141 FAM36A 0.44 6.03 0.32 4.28e-9 Response to antipsychotic treatment; CRC cis rs3741151 0.686 rs7941359 chr11:73158119 A/G cg17517138 chr11:73019481 ARHGEF17 0.55 5.84 0.31 1.25e-8 GIP levels in response to oral glucose tolerance test (120 minutes); CRC cis rs367615 0.661 rs9326773 chr5:108833523 C/T cg17395555 chr5:108820864 NA 0.45 8.97 0.44 2.28e-17 Colorectal cancer (SNP x SNP interaction); CRC cis rs4969178 0.896 rs12602206 chr17:76397133 A/G cg05887092 chr17:76393375 PGS1 0.55 10.0 0.48 1e-20 HDL cholesterol levels; CRC cis rs873946 0.590 rs7071777 chr10:134559976 T/A cg26818010 chr10:134567672 INPP5A -0.64 -8.11 -0.41 9.95e-15 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CRC cis rs910316 0.737 rs175080 chr14:75513828 G/A cg08847533 chr14:75593920 NEK9 -0.86 -14.98 -0.64 4.91e-39 Height; CRC cis rs344364 0.511 rs1657132 chr16:1949924 C/T cg09830162 chr16:1889614 FAHD1;C16orf73 -0.77 -9.2 -0.45 4.39e-18 Glomerular filtration rate in chronic kidney disease; CRC cis rs7312933 0.558 rs11181502 chr12:42823833 A/G cg11827402 chr12:42719852 PPHLN1;ZCRB1 0.67 9.67 0.47 1.22e-19 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CRC cis rs208520 0.909 rs9354410 chr6:67018584 C/T cg07460842 chr6:66804631 NA 0.82 9.83 0.48 3.69e-20 Exhaled nitric oxide output; CRC cis rs2991971 0.810 rs998199 chr1:45912898 A/C cg24296786 chr1:45957014 TESK2 -0.49 -7.31 -0.37 1.98e-12 High light scatter reticulocyte count; CRC cis rs769267 0.965 rs6511026 chr19:19391402 C/T cg01262667 chr19:19385393 TM6SF2 0.36 5.87 0.31 1.06e-8 Tonsillectomy; CRC cis rs13108904 0.870 rs13110563 chr4:1255772 G/C cg00684032 chr4:1343700 KIAA1530 0.47 7.05 0.36 1.09e-11 Obesity-related traits; CRC trans rs66573146 0.634 rs56097119 chr4:7018692 C/G cg07817883 chr1:32538562 TMEM39B 1.26 10.91 0.52 7.39e-24 Granulocyte percentage of myeloid white cells; CRC cis rs12048904 0.541 rs6699536 chr1:101276544 A/G cg16556008 chr1:101360663 SLC30A7;EXTL2 0.81 12.37 0.56 3.97e-29 Multiple sclerosis; CRC cis rs9549328 0.800 rs9549617 chr13:113628070 C/A cg17524180 chr13:113633600 MCF2L -0.68 -12.87 -0.58 5.53e-31 Systolic blood pressure; CRC cis rs9858542 0.953 rs11926781 chr3:49603289 C/T cg03060546 chr3:49711283 APEH -0.48 -6.5 -0.34 2.92e-10 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs7493 0.950 rs56265549 chr7:95047155 G/A cg01874867 chr7:94954059 PON1 -0.48 -6.19 -0.32 1.81e-9 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs992157 1.000 rs4791 chr2:219138940 C/T cg00012203 chr2:219082015 ARPC2 0.53 8.59 0.43 3.65e-16 Colorectal cancer; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg11081703 chr12:108909056 FICD 0.38 6.22 0.32 1.55e-9 Liver disease severity in Alagille syndrome; CRC cis rs6121246 0.954 rs6121245 chr20:30432060 G/A cg13852791 chr20:30311386 BCL2L1 0.59 9.62 0.47 1.77e-19 Mean corpuscular hemoglobin; CRC cis rs651907 0.535 rs11714444 chr3:101513682 G/A cg11279151 chr3:101281821 RG9MTD1 -0.53 -7.09 -0.36 8.3e-12 Colorectal cancer; CRC cis rs9611565 0.649 rs79009 chr22:41860864 C/A cg03806693 chr22:41940476 POLR3H 1.09 14.79 0.63 2.54e-38 Vitiligo; CRC cis rs798554 0.757 rs1182176 chr7:2874601 A/G cg14863265 chr7:2801509 GNA12 -0.4 -5.82 -0.31 1.41e-8 Height; CRC cis rs2180341 0.618 rs11154398 chr6:127654281 C/A cg27446573 chr6:127587934 RNF146 0.62 9.17 0.45 5.19e-18 Breast cancer; CRC trans rs11343 0.675 rs7359333 chr16:19262344 A/T cg06207806 chr3:122512713 DIRC2;HSPBAP1 -0.48 -5.99 -0.31 5.65e-9 Parkinson's disease; CRC cis rs4253772 0.550 rs6008613 chr22:46707924 G/T cg24881330 chr22:46731750 TRMU 0.59 6.36 0.33 6.75e-10 LDL cholesterol;Cholesterol, total; CRC cis rs644799 1.000 rs568668 chr11:95528209 G/A cg25478527 chr11:95522999 CEP57;FAM76B 0.51 7.69 0.39 1.7e-13 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs2019137 0.936 rs2241978 chr2:113954006 A/G cg21550016 chr2:113992930 PAX8;LOC440839;LOC654433 -0.52 -7.42 -0.38 1e-12 Lymphocyte counts; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg08495106 chr7:152161143 LOC100128822 0.42 6.13 0.32 2.53e-9 Intelligence (multi-trait analysis); CRC cis rs2832191 0.740 rs2832175 chr21:30475606 A/G cg08807101 chr21:30365312 RNF160 -0.68 -10.9 -0.51 8.15e-24 Dental caries; CRC trans rs1864729 1.000 rs2853320 chr8:98283523 C/G cg08679828 chr8:102218111 ZNF706 -0.59 -7.13 -0.37 6.34e-12 Estradiol plasma levels (breast cancer); CRC cis rs8105895 0.935 rs10406553 chr19:22237801 G/T cg02657401 chr19:22469223 NA -0.34 -5.65 -0.3 3.56e-8 Body mass index (change over time); CRC cis rs7666738 0.830 rs880472 chr4:98922595 C/A cg05340658 chr4:99064831 C4orf37 0.6 9.35 0.46 1.41e-18 Colonoscopy-negative controls vs population controls; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg19485873 chr19:48972334 CYTH2 0.39 6.03 0.32 4.31e-9 Intelligence (multi-trait analysis); CRC cis rs11679072 1.000 rs74002837 chr2:240449710 C/T cg03276489 chr2:240449683 NA -0.89 -8.87 -0.44 4.89e-17 Blood pressure (smoking interaction); CRC cis rs864537 0.622 rs1214598 chr1:167426424 C/T cg09179987 chr1:167433047 CD247 0.46 6.49 0.34 3.16e-10 Celiac disease or Rheumatoid arthritis;Celiac disease; CRC cis rs727479 0.502 rs12591172 chr15:51503727 G/A cg19946085 chr15:51559439 CYP19A1 -0.31 -6.43 -0.33 4.6e-10 Estradiol levels; CRC cis rs13108904 0.901 rs4516656 chr4:1279860 A/G cg00684032 chr4:1343700 KIAA1530 0.48 7.08 0.36 8.57e-12 Obesity-related traits; CRC cis rs4423214 1.000 rs2852853 chr11:71150217 C/T cg05163923 chr11:71159392 DHCR7 0.65 9.32 0.46 1.72e-18 Vitamin D levels; CRC cis rs4654899 0.571 rs1888759 chr1:21065167 G/A cg02927042 chr1:21476669 EIF4G3 -0.36 -5.6 -0.3 4.5e-8 Superior frontal gyrus grey matter volume; CRC cis rs2836974 0.568 rs429955 chr21:40539760 G/A cg22974920 chr21:40686053 BRWD1 0.43 6.08 0.32 3.39e-9 Cognitive function; CRC cis rs6540559 0.740 rs2064163 chr1:210048819 G/T cg22029157 chr1:209979665 IRF6 0.57 7.9 0.4 4.29e-14 Cleft lip with or without cleft palate; CRC cis rs1619661 0.530 rs7909598 chr10:44688935 T/C cg09554077 chr10:44749378 NA 0.49 7.51 0.38 5.71e-13 QT interval (ambient particulate matter interaction); CRC cis rs1127311 1.000 rs1127311 chr1:154556663 G/A cg17218026 chr1:154582156 ADAR 0.58 9.85 0.48 3.15e-20 C-reactive protein levels or triglyceride levels (pleiotropy); CRC cis rs9467711 0.606 rs34273322 chr6:26415409 T/A cg08501292 chr6:25962987 TRIM38 0.79 6.17 0.32 2e-9 Autism spectrum disorder or schizophrenia; CRC cis rs4862750 0.872 rs13101408 chr4:187894777 G/A cg22105103 chr4:187893119 NA 0.65 11.83 0.55 3.87e-27 Lobe attachment (rater-scored or self-reported); CRC cis rs8177253 1.000 rs8177247 chr3:133479499 T/G cg16262614 chr3:133464971 TF 0.33 5.89 0.31 9.5e-9 Iron status biomarkers; CRC cis rs10751667 0.666 rs7105477 chr11:964271 C/G ch.11.42038R chr11:967971 AP2A2 0.56 9.37 0.46 1.18e-18 Alzheimer's disease (late onset); CRC trans rs1814175 0.817 rs4881648 chr11:49812901 A/G cg15704280 chr7:45808275 SEPT13 -1.0 -19.77 -0.74 7.1e-58 Height; CRC cis rs8053891 0.585 rs12926804 chr16:71994932 A/G cg04254540 chr16:71951199 KIAA0174 -0.96 -9.7 -0.47 9.78e-20 Coronary artery disease; CRC cis rs2239547 0.657 rs2072391 chr3:52862200 C/T cg11645453 chr3:52864694 ITIH4 0.62 11.22 0.53 5.75e-25 Schizophrenia; CRC cis rs3540 0.960 rs28539372 chr15:91021412 T/A cg22089800 chr15:90895588 ZNF774 0.48 7.44 0.38 8.71e-13 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; CRC cis rs6840360 1.000 rs6818667 chr4:152598698 T/C cg09659197 chr4:152720779 NA 0.52 11.24 0.53 4.87e-25 Intelligence (multi-trait analysis); CRC cis rs11716531 0.574 rs13075192 chr3:27279235 C/T cg02860705 chr3:27208620 NA 0.7 9.48 0.46 5.18e-19 Diastolic blood pressure; CRC cis rs9463078 0.774 rs4510673 chr6:45350107 A/G cg25276700 chr6:44698697 NA 0.28 6.67 0.35 1.08e-10 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; CRC cis rs35306767 0.855 rs55708963 chr10:925712 C/A cg26597838 chr10:835615 NA 1.19 14.24 0.62 3.52e-36 Eosinophil percentage of granulocytes; CRC cis rs2565722 0.723 rs2489941 chr6:161285517 C/T cg03159191 chr6:161285451 NA -0.47 -6.29 -0.33 1e-9 Blood protein levels; CRC cis rs501120 0.657 rs646890 chr10:44741710 C/T cg09554077 chr10:44749378 NA 0.83 10.78 0.51 2.11e-23 Coronary artery disease;Coronary heart disease; CRC cis rs34172651 0.917 rs7204281 chr16:24784475 C/T cg06028605 chr16:24865363 SLC5A11 0.45 8.02 0.4 1.84e-14 Intelligence (multi-trait analysis); CRC cis rs11112613 0.775 rs12305225 chr12:105963266 G/C cg03607813 chr12:105948248 NA 0.6 8.49 0.42 7.19e-16 Corrected insulin response;Corrected insulin response adjusted for insulin sensitivity index; CRC cis rs7615952 0.932 rs1976458 chr3:125647512 T/G cg05084668 chr3:125655381 ALG1L -0.61 -9.21 -0.45 3.84e-18 Blood pressure (smoking interaction); CRC cis rs172166 0.516 rs2791333 chr6:28111114 A/G cg03623178 chr6:28175578 NA 0.66 10.08 0.49 5.22e-21 Cardiac Troponin-T levels; CRC cis rs2204008 0.805 rs11522896 chr12:38234427 T/C cg26384229 chr12:38710491 ALG10B 0.7 9.31 0.46 1.92e-18 Bladder cancer; CRC cis rs6860806 0.507 rs2631364 chr5:131706914 C/G cg02033258 chr5:131593261 PDLIM4 -0.38 -6.48 -0.34 3.33e-10 Breast cancer; CRC cis rs7618915 0.570 rs4687633 chr3:52630548 G/A cg18099408 chr3:52552593 STAB1 -0.44 -7.31 -0.37 2e-12 Bipolar disorder; CRC cis rs2153535 0.580 rs1335643 chr6:8488021 T/G cg21535247 chr6:8435926 SLC35B3 0.5 7.51 0.38 5.54e-13 Motion sickness; CRC cis rs4243830 0.850 rs2412309 chr1:6603151 A/G cg15205204 chr1:6545172 PLEKHG5 0.38 5.66 0.3 3.22e-8 Body mass index; CRC trans rs7824557 0.606 rs1047950 chr8:11185096 G/C cg06636001 chr8:8085503 FLJ10661 0.46 6.8 0.35 4.88e-11 Retinal vascular caliber; CRC cis rs7618915 0.501 rs2336149 chr3:52692124 G/A cg18404041 chr3:52824283 ITIH1 -0.41 -8.66 -0.43 2.11e-16 Bipolar disorder; CRC cis rs2760061 0.598 rs2796056 chr1:228122901 G/A cg02753203 chr1:228287806 NA -0.66 -10.25 -0.49 1.42e-21 Diastolic blood pressure; CRC cis rs7804356 0.859 rs2391362 chr7:26907123 T/C cg03456212 chr7:26904342 SKAP2 -0.52 -5.81 -0.31 1.48e-8 Type 1 diabetes; CRC cis rs7224685 0.501 rs2727064 chr17:3934101 A/G cg09597638 chr17:3907349 NA 0.63 10.95 0.52 5.13e-24 Type 2 diabetes; CRC cis rs17127169 0.649 rs41285422 chr1:65467871 T/G cg01340542 chr1:65468273 NA 0.81 5.63 0.3 3.87e-8 Sitting height ratio; CRC cis rs1552244 1.000 rs3895942 chr3:10108745 G/C cg02579736 chr3:10068473 FANCD2;CIDECP 0.96 12.9 0.58 4.44e-31 Alzheimer's disease; CRC cis rs1878931 0.582 rs9635562 chr16:3416689 G/A cg26668626 chr16:3451006 ZNF174;ZNF434 0.54 6.74 0.35 7.01e-11 Body mass index (adult); CRC trans rs9747201 0.962 rs62078313 chr17:80116708 A/C cg07393940 chr7:158741817 NA -0.52 -7.51 -0.38 5.44e-13 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs17376456 0.569 rs2045020 chr5:93224466 T/C cg21475434 chr5:93447410 FAM172A -0.51 -6.11 -0.32 2.81e-9 Diabetic retinopathy; CRC cis rs10256972 0.552 rs6978842 chr7:1204599 A/C cg22907277 chr7:1156413 C7orf50 0.65 10.13 0.49 3.54e-21 Longevity;Endometriosis; CRC cis rs10504229 0.775 rs55734109 chr8:58162322 G/A cg02725872 chr8:58115012 NA -0.59 -8.85 -0.44 5.51e-17 Developmental language disorder (linguistic errors); CRC cis rs4665809 0.816 rs2384359 chr2:26371364 T/C cg04944784 chr2:26401820 FAM59B -0.73 -8.51 -0.42 6.05e-16 Gut microbiome composition (summer); CRC cis rs2882667 0.898 rs6867343 chr5:138374428 C/T cg09476006 chr5:138032270 NA 0.44 7.44 0.38 9.02e-13 Age-related hearing impairment (SNP x SNP interaction); CRC trans rs951252 0.504 rs11734405 chr4:146081096 C/T cg22264975 chr6:90121670 RRAGD 0.33 6.3 0.33 9.37e-10 Hip circumference; CRC cis rs9463078 0.764 rs3846896 chr6:44834094 G/A cg25276700 chr6:44698697 NA -0.27 -6.55 -0.34 2.26e-10 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; CRC cis rs7772486 0.686 rs9497396 chr6:146014963 C/A cg23711669 chr6:146136114 FBXO30 -0.65 -10.83 -0.51 1.44e-23 Lobe attachment (rater-scored or self-reported); CRC cis rs2952156 0.920 rs2934956 chr17:37830447 T/A cg11212589 chr17:38028394 ZPBP2 0.35 6.16 0.32 2.08e-9 Asthma; CRC cis rs12134245 0.874 rs35115044 chr1:92021650 A/G cg02896835 chr1:92012615 NA -0.48 -7.67 -0.39 1.92e-13 Breast cancer; CRC cis rs898097 0.841 rs11656358 chr17:80853956 G/A cg16060761 chr17:80687452 NA 0.43 6.23 0.33 1.39e-9 Breast cancer; CRC trans rs9929218 1.000 rs13334471 chr16:68800452 T/C cg04657470 chr2:198365150 HSPE1;HSPD1 -0.83 -11.86 -0.55 2.96e-27 Colorectal cancer; CRC cis rs17125944 0.505 rs77690283 chr14:53233320 C/G cg00686598 chr14:53173677 PSMC6 1.18 10.99 0.52 3.92e-24 Alzheimer's disease (late onset); CRC cis rs7177699 0.550 rs4468572 chr15:79124475 C/T cg15571903 chr15:79123663 NA -0.34 -6.92 -0.36 2.41e-11 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg11510247 chr12:21590784 PYROXD1 0.41 6.47 0.34 3.56e-10 Liver disease severity in Alagille syndrome; CRC cis rs13108904 0.901 rs7695691 chr4:1304632 A/G cg20092199 chr4:1342459 KIAA1530 0.37 6.63 0.34 1.35e-10 Obesity-related traits; CRC cis rs79349575 0.783 rs9747646 chr17:47016882 C/T cg00947319 chr17:47005597 UBE2Z -0.34 -5.89 -0.31 9.32e-9 Type 2 diabetes; CRC cis rs2692947 0.860 rs2579520 chr2:96660300 C/T cg23100626 chr2:96804247 ASTL -0.24 -6.72 -0.35 7.92e-11 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; CRC cis rs911119 0.913 rs6048928 chr20:23585988 A/G cg16589663 chr20:23618590 CST3 0.58 7.62 0.39 2.78e-13 Chronic kidney disease; CRC cis rs6502050 0.835 rs12051747 chr17:80114814 T/C cg19223190 chr17:80058835 NA 0.39 6.2 0.32 1.67e-9 Life satisfaction; CRC cis rs561341 0.830 rs2301765 chr17:30202056 T/A cg13647721 chr17:30228624 UTP6 -0.56 -5.68 -0.3 3.04e-8 Hip circumference adjusted for BMI; CRC cis rs769267 0.930 rs2315022 chr19:19413381 A/G cg17414380 chr19:19431394 KIAA0892;SF4 0.42 5.68 0.3 2.89e-8 Tonsillectomy; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg25940730 chr4:16228647 TAPT1;FLJ39653 -0.45 -6.5 -0.34 3.02e-10 Myopia (pathological); CRC cis rs9322193 0.923 rs4869812 chr6:149990583 A/G cg00933542 chr6:150070202 PCMT1 0.3 6.06 0.32 3.71e-9 Lung cancer; CRC cis rs6582630 0.555 rs10880602 chr12:38505660 T/C cg13010199 chr12:38710504 ALG10B 0.47 6.44 0.33 4.34e-10 Drug-induced liver injury (flucloxacillin); CRC cis rs6594499 0.843 rs1993465 chr5:110433098 A/G cg04022379 chr5:110408740 TSLP 0.45 6.89 0.35 2.9100000000000002e-11 Allergic disease (asthma, hay fever or eczema); CRC cis rs4862750 0.872 rs9998173 chr4:187898778 T/A cg03452623 chr4:187889614 NA -0.93 -21.91 -0.77 3.09e-66 Lobe attachment (rater-scored or self-reported); CRC cis rs924607 1.000 rs11746907 chr5:598224 G/A cg01605746 chr5:669925 TPPP -0.34 -5.68 -0.3 2.92e-8 Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia; CRC cis rs17253792 0.822 rs78143160 chr14:56150097 A/G cg01858014 chr14:56050164 KTN1 -0.88 -7.22 -0.37 3.55e-12 Putamen volume; CRC cis rs4555082 0.874 rs2816621 chr14:105732762 A/T cg18132624 chr14:105716052 BTBD6;BRF1 -0.47 -7.45 -0.38 8.37e-13 Mean platelet volume;Platelet distribution width; CRC cis rs7762018 0.891 rs12529402 chr6:170147675 A/T cg19338460 chr6:170058176 WDR27 -0.69 -7.6 -0.39 3.03e-13 Thiazide-induced adverse metabolic effects in hypertensive patients; CRC cis rs12575642 0.660 rs58632573 chr11:63896299 C/T cg23719950 chr11:63933701 MACROD1 -0.65 -8.25 -0.41 3.86e-15 Attention deficit hyperactivity disorder; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg02851105 chr16:734504 JMJD8 0.47 6.34 0.33 7.38e-10 Anxiety disorder; CRC cis rs17384381 1.000 rs12140935 chr1:85855716 G/A cg16011679 chr1:85725395 C1orf52 0.63 6.45 0.33 4.05e-10 Lobe attachment (rater-scored or self-reported); CRC cis rs12142240 0.698 rs72885198 chr1:46812888 C/T cg00530320 chr1:46809349 NSUN4 0.58 7.8 0.4 8.18e-14 Menopause (age at onset); CRC cis rs362272 0.505 rs10155132 chr4:3369500 A/G cg02993699 chr4:3415135 RGS12 -0.39 -6.51 -0.34 2.8e-10 Serum sulfate level; CRC cis rs6694672 0.717 rs10733087 chr1:197055782 T/C cg13682187 chr1:196946512 CFHR5 0.48 7.65 0.39 2.3e-13 Asthma; CRC cis rs7402982 0.625 rs4966008 chr15:99203445 A/G cg03437748 chr15:99193247 IGF1R -0.57 -7.7 -0.39 1.5700000000000001e-13 Birth weight; CRC cis rs7937682 0.883 rs529529 chr11:111461128 C/T cg19812747 chr11:111475976 SIK2 -0.57 -9.72 -0.47 8.51e-20 Primary sclerosing cholangitis; CRC cis rs1050631 0.564 rs1625385 chr18:33717364 C/A cg25426722 chr18:33708991 SLC39A6;ELP2 0.37 5.69 0.3 2.8e-8 Esophageal squamous cell cancer (length of survival); CRC cis rs1448094 0.511 rs7968059 chr12:86163606 A/G cg19622623 chr12:86230825 RASSF9 -0.37 -5.73 -0.3 2.33e-8 Major depressive disorder; CRC cis rs10504229 1.000 rs57624567 chr8:58176995 T/C cg02290350 chr8:58132656 NA -0.42 -5.96 -0.31 6.62e-9 Developmental language disorder (linguistic errors); CRC trans rs2243480 0.708 rs35310401 chr7:65390359 A/G cg10756647 chr7:56101905 PSPH 0.73 8.07 0.41 1.36e-14 Diabetic kidney disease; CRC cis rs644799 0.965 rs607039 chr11:95547086 G/A cg25478527 chr11:95522999 CEP57;FAM76B 0.51 7.69 0.39 1.68e-13 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs7772486 0.790 rs4280983 chr6:146280790 G/C cg13319975 chr6:146136371 FBXO30 0.43 6.45 0.34 3.98e-10 Lobe attachment (rater-scored or self-reported); CRC cis rs1878931 0.535 rs7188903 chr16:3412861 A/G cg26668626 chr16:3451006 ZNF174;ZNF434 0.51 6.26 0.33 1.18e-9 Body mass index (adult); CRC cis rs7618915 0.501 rs10865974 chr3:52718280 A/C cg08222913 chr3:52553049 STAB1 0.35 6.53 0.34 2.48e-10 Bipolar disorder; CRC cis rs10927875 0.757 rs4661679 chr1:16321010 C/T cg21385522 chr1:16154831 NA 0.4 5.61 0.3 4.35e-8 Dilated cardiomyopathy; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg13819485 chr11:118868642 CCDC84 0.51 7.2 0.37 4.2e-12 Response to antipsychotic treatment; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg00526316 chr1:151043472 GABPB2 0.51 7.26 0.37 2.84e-12 Response to antipsychotic treatment; CRC trans rs10982213 0.830 rs2274163 chr9:117188714 C/T cg26591144 chr17:1532201 SLC43A2 0.4 6.29 0.33 9.84e-10 Interleukin-6 levels; CRC cis rs2346160 0.867 rs2989555 chr6:167704244 C/T cg04673565 chr6:167680447 NA -0.33 -5.67 -0.3 3.06e-8 Parental extreme longevity (95 years and older); CRC cis rs9427116 0.875 rs11264233 chr1:154625632 C/T cg17218026 chr1:154582156 ADAR 0.55 8.79 0.44 8.58e-17 Blood protein levels; CRC cis rs6570726 1.000 rs1935615 chr6:145921117 G/T cg23711669 chr6:146136114 FBXO30 0.69 11.17 0.52 8.91e-25 Lobe attachment (rater-scored or self-reported); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg00066449 chr7:99063909 ATP5J2 0.44 6.06 0.32 3.63e-9 Response to antipsychotic treatment; CRC cis rs6545883 0.868 rs6545887 chr2:61828818 C/G cg15711740 chr2:61764176 XPO1 -0.52 -7.14 -0.37 6.11e-12 Tuberculosis; CRC cis rs9916302 0.904 rs12450559 chr17:37694709 G/A cg03013999 chr17:37608204 MED1 0.45 6.86 0.35 3.45e-11 Glomerular filtration rate (creatinine); CRC cis rs7178572 0.568 rs12910480 chr15:77664212 G/C cg22256960 chr15:77711686 NA -0.65 -9.33 -0.46 1.56e-18 Type 2 diabetes; CRC cis rs11098499 0.955 rs7685268 chr4:120162188 G/A cg09307838 chr4:120376055 NA 0.61 9.41 0.46 8.75e-19 Corneal astigmatism; CRC cis rs2153535 0.580 rs1335641 chr6:8487860 G/T cg07606381 chr6:8435919 SLC35B3 0.68 10.89 0.51 8.84e-24 Motion sickness; CRC cis rs17376456 0.757 rs10066431 chr5:93198204 A/G cg21475434 chr5:93447410 FAM172A 0.75 7.34 0.37 1.73e-12 Diabetic retinopathy; CRC trans rs7618501 0.966 rs13085679 chr3:49869631 G/A cg21582582 chr3:182698605 DCUN1D1 0.53 7.65 0.39 2.17e-13 Intelligence (multi-trait analysis); CRC cis rs72615157 0.634 rs74774557 chr7:99810425 A/G cg16268157 chr7:99778414 STAG3 -0.44 -5.82 -0.31 1.36e-8 Lung function (FEV1/FVC); CRC cis rs775227 1.000 rs35341359 chr3:112994937 A/G cg18753928 chr3:113234510 CCDC52 -0.45 -5.64 -0.3 3.6e-8 Dental caries; CRC cis rs9560113 1.000 rs4773387 chr13:112180955 T/C cg10483660 chr13:112241077 NA 0.36 5.77 0.3 1.87e-8 Menarche (age at onset); CRC trans rs728616 0.614 rs35395602 chr10:81906770 A/G cg18543242 chr14:23290393 SLC7A7 0.45 6.08 0.32 3.29e-9 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs28386778 0.897 rs11654841 chr17:61838259 C/T cg22520471 chr17:61851767 DDX42;CCDC47 0.75 11.77 0.54 6.44e-27 Prudent dietary pattern; CRC cis rs1348850 0.958 rs4243390 chr2:178468008 G/A cg02961200 chr2:178257176 LOC100130691;AGPS 0.52 7.5 0.38 6.01e-13 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs208520 0.586 rs208442 chr6:66900618 T/A cg07460842 chr6:66804631 NA -0.67 -9.35 -0.46 1.4e-18 Exhaled nitric oxide output; CRC cis rs7119 0.717 rs12904348 chr15:77815738 G/C cg10437265 chr15:77819839 NA 0.67 12.5 0.57 1.31e-29 Type 2 diabetes; CRC cis rs1757171 0.504 rs11969056 chr6:37484285 C/T cg25019722 chr6:37503610 NA -0.44 -8.11 -0.41 1.01e-14 Cognitive performance; CRC cis rs28386778 0.591 rs2584619 chr17:61913215 T/A cg07362569 chr17:61921086 SMARCD2 0.38 5.89 0.31 9.68e-9 Prudent dietary pattern; CRC cis rs13064411 0.518 rs9870996 chr3:113238375 A/C cg18753928 chr3:113234510 CCDC52 -0.47 -7.33 -0.37 1.78e-12 Response to simvastatin treatment (PCSK9 protein level change); CRC cis rs4604732 0.631 rs56704806 chr1:247626148 T/C cg12758973 chr1:247694275 LOC148824;OR2C3 0.42 6.18 0.32 1.9e-9 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CRC cis rs59918340 0.764 rs10101692 chr8:142230823 C/T cg23750338 chr8:142222470 SLC45A4 0.62 11.45 0.53 8.95e-26 Immature fraction of reticulocytes; CRC cis rs11711311 0.955 rs9830102 chr3:113408302 C/A cg15478005 chr3:113465772 ATP6V1A;NAA50 0.46 6.31 0.33 9.17e-10 IgG glycosylation; CRC cis rs1448094 0.512 rs61930864 chr12:86246740 G/A cg02569458 chr12:86230093 RASSF9 0.43 7.4 0.38 1.17e-12 Major depressive disorder; CRC cis rs13323323 0.691 rs9814256 chr3:44668037 A/T cg14768256 chr3:44754587 ZNF502 -0.49 -6.26 -0.33 1.2e-9 IgG glycosylation; CRC cis rs853679 0.546 rs175597 chr6:27810626 T/C cg19041857 chr6:27730383 NA -0.69 -6.52 -0.34 2.68e-10 Depression; CRC cis rs2032447 0.613 rs6456708 chr6:26032847 G/C cg17691542 chr6:26056736 HIST1H1C 0.39 5.96 0.31 6.53e-9 Intelligence (multi-trait analysis); CRC cis rs2857891 0.817 rs2638101 chr11:6969131 G/A cg04053776 chr11:6947353 ZNF215 0.39 5.64 0.3 3.68e-8 Response to cytadine analogues (cytosine arabinoside); CRC cis rs1568889 1.000 rs9783375 chr11:28033667 C/T cg06544937 chr11:28130018 METT5D1;KIF18A 0.77 10.49 0.5 2.13e-22 Bipolar disorder; CRC cis rs6952808 0.692 rs11773316 chr7:2027354 C/T cg21782813 chr7:2030301 MAD1L1 0.56 9.77 0.47 5.73e-20 Bipolar disorder and schizophrenia; CRC trans rs1455244 0.700 rs7229302 chr18:11508904 G/T cg22917237 chr19:18633401 ELL 0.4 6.37 0.33 6.48e-10 Schizophrenia; CRC cis rs3096299 0.900 rs4785663 chr16:89434888 G/A cg01788221 chr16:89496183 ANKRD11 -0.39 -5.85 -0.31 1.18e-8 Multiple myeloma (IgH translocation); CRC cis rs3026101 0.723 rs1806247 chr17:5310409 T/C cg25236894 chr17:5323110 RPAIN;NUP88 0.42 6.9 0.36 2.74e-11 Body mass index; CRC cis rs2952156 0.652 rs11869286 chr17:37813856 C/G cg15445000 chr17:37608096 MED1 0.27 6.09 0.32 3.22e-9 Asthma; CRC cis rs9903692 0.908 rs12950402 chr17:46180114 A/G cg21215337 chr17:46176117 CBX1 -0.43 -7.98 -0.4 2.46e-14 Pulse pressure; CRC cis rs11098499 0.909 rs10002083 chr4:120311152 C/T cg24375607 chr4:120327624 NA 0.51 7.86 0.4 5.5e-14 Corneal astigmatism; CRC cis rs10463316 0.779 rs6871318 chr5:150801545 G/A cg03212797 chr5:150827313 SLC36A1 -0.52 -7.83 -0.4 6.69e-14 Metabolite levels (Pyroglutamine); CRC cis rs1799949 1.000 rs11657053 chr17:41191129 G/T cg25072359 chr17:41440525 NA 0.47 6.92 0.36 2.32e-11 Menopause (age at onset); CRC cis rs2839186 0.632 rs2839184 chr21:47689013 G/A cg20399509 chr21:47717575 C21orf57 -0.37 -5.8 -0.3 1.54e-8 Testicular germ cell tumor; CRC cis rs4363385 0.510 rs6587724 chr1:153034501 T/A cg25856811 chr1:152973957 SPRR3 -0.21 -5.69 -0.3 2.87e-8 Inflammatory skin disease; CRC cis rs2836974 0.568 rs377098 chr21:40535216 G/A cg06238570 chr21:40685208 BRWD1 -0.79 -12.75 -0.58 1.52e-30 Cognitive function; CRC cis rs35110281 0.667 rs2838354 chr21:45119857 T/C cg21573476 chr21:45109991 RRP1B -0.4 -5.95 -0.31 7.01e-9 Mean corpuscular volume; CRC cis rs17666538 0.585 rs1703927 chr8:613620 A/G cg07685180 chr8:600429 NA -0.63 -6.4 -0.33 5.39e-10 IgG glycosylation; CRC trans rs116095464 0.558 rs9654452 chr5:299561 C/T cg00938859 chr5:1591904 SDHAP3 0.71 7.49 0.38 6.55e-13 Breast cancer; CRC cis rs6684514 1.000 rs12117947 chr1:156244058 A/T cg16558208 chr1:156270281 VHLL 0.58 9.08 0.45 1.03e-17 Mean corpuscular hemoglobin concentration;Glycated hemoglobin levels; CRC cis rs644799 1.000 rs623191 chr11:95548359 A/G cg25622487 chr11:95524042 FAM76B;CEP57 0.76 11.87 0.55 2.62e-27 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs62458065 0.713 rs62463967 chr7:32498329 G/A cg20159608 chr7:32802032 NA -0.6 -7.25 -0.37 2.99e-12 Metabolite levels (HVA/MHPG ratio); CRC cis rs988712 0.705 rs1829469 chr11:27730556 A/G cg10635145 chr11:27742435 BDNF -0.4 -5.81 -0.3 1.48e-8 Obesity; CRC cis rs10883723 0.810 rs3818470 chr10:104263675 T/C cg04362960 chr10:104952993 NT5C2 -0.43 -6.1 -0.32 2.92e-9 Allergic disease (asthma, hay fever or eczema); CRC cis rs10504229 0.683 rs11786843 chr8:58133629 T/C cg24829409 chr8:58192753 C8orf71 -0.56 -8.31 -0.42 2.48e-15 Developmental language disorder (linguistic errors); CRC cis rs4713118 0.527 rs36042294 chr6:27720712 C/G cg02683197 chr6:28174875 NA 0.61 8.7 0.43 1.64e-16 Parkinson's disease; CRC cis rs62367758 0.683 rs316403 chr5:43072724 A/G cg09164108 chr5:43007320 NA -0.47 -5.79 -0.3 1.65e-8 Facial morphology (factor 8, orbital inclination due to vertical and horizontal position of exocanthion); CRC cis rs8077889 0.871 rs72836549 chr17:41904360 G/T cg25876840 chr17:41920477 NA 0.61 8.58 0.43 3.91e-16 Triglycerides; CRC trans rs11098499 0.913 rs11098496 chr4:120167466 C/G cg25214090 chr10:38739885 LOC399744 0.51 7.85 0.4 5.76e-14 Corneal astigmatism; CRC cis rs9916302 0.904 rs602688 chr17:37439496 C/T cg07936489 chr17:37558343 FBXL20 -0.76 -11.22 -0.53 6.03e-25 Glomerular filtration rate (creatinine); CRC cis rs68170813 0.559 rs75723759 chr7:106962407 A/G cg02696742 chr7:106810147 HBP1 -0.56 -6.07 -0.32 3.45e-9 Coronary artery disease; CRC cis rs10504229 0.953 rs75253516 chr8:58171547 C/A cg05313129 chr8:58192883 C8orf71 -0.47 -6.86 -0.35 3.35e-11 Developmental language disorder (linguistic errors); CRC cis rs35146811 0.735 rs1636978 chr7:99813912 G/A cg13334819 chr7:99746414 C7orf59 0.58 7.43 0.38 9.74e-13 Coronary artery disease; CRC cis rs6460942 0.915 rs6966791 chr7:12439714 T/C cg06484146 chr7:12443880 VWDE -0.81 -8.52 -0.43 5.76e-16 Coronary artery disease; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg03387111 chr3:101292956 PCNP 0.4 6.22 0.32 1.52e-9 Intelligence (multi-trait analysis); CRC cis rs1552244 1.000 rs6414438 chr3:10073824 G/C cg18598329 chr3:10140678 FANCD2;C3orf24 -0.88 -12.36 -0.56 4.52e-29 Alzheimer's disease; CRC cis rs11098499 0.954 rs11098525 chr4:120390152 G/A cg09307838 chr4:120376055 NA 0.71 10.97 0.52 4.45e-24 Corneal astigmatism; CRC cis rs899997 1.000 rs9888691 chr15:79010046 T/C cg22753661 chr15:79092743 ADAMTS7 0.4 5.72 0.3 2.45e-8 Coronary artery disease or large artery stroke; CRC cis rs1008375 1.000 rs55939327 chr4:17642937 T/A cg02297831 chr4:17616191 MED28 0.43 5.72 0.3 2.39e-8 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs10504229 0.683 rs6982990 chr8:58115275 C/T cg21724239 chr8:58056113 NA -0.49 -7.06 -0.36 9.66e-12 Developmental language disorder (linguistic errors); CRC cis rs7705042 0.793 rs1036207 chr5:141499041 A/G cg08523384 chr5:141488047 NDFIP1 -0.34 -5.95 -0.31 6.98e-9 Asthma; CRC cis rs926938 0.527 rs360594 chr1:115472401 G/A cg12756093 chr1:115239321 AMPD1 0.48 7.09 0.36 8.36e-12 Autism; CRC cis rs881375 1.000 rs1953126 chr9:123640500 T/C cg09419670 chr9:123605666 PSMD5;LOC253039 0.59 8.67 0.43 1.97e-16 Rheumatoid arthritis; CRC cis rs9916302 0.904 rs57399933 chr17:37551189 A/G cg07936489 chr17:37558343 FBXL20 0.85 13.38 0.59 6.93e-33 Glomerular filtration rate (creatinine); CRC cis rs8177179 0.967 rs4287912 chr3:133437778 A/G cg17775713 chr3:133465469 TF 0.32 5.84 0.31 1.22e-8 Iron status biomarkers (transferrin levels); CRC cis rs2243480 0.901 rs778732 chr7:65822360 C/T cg18252515 chr7:66147081 NA -1.27 -14.53 -0.63 2.75e-37 Diabetic kidney disease; CRC cis rs1552244 1.000 rs4269070 chr3:10126083 C/G cg10729496 chr3:10149963 C3orf24 0.51 6.89 0.35 2.92e-11 Alzheimer's disease; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg21819024 chr1:52344978 NRD1 0.46 5.97 0.31 6.29e-9 Thyroid stimulating hormone; CRC cis rs9549367 0.713 rs3024776 chr13:113827075 A/G cg24300038 chr13:113819356 PROZ 0.46 5.67 0.3 3.09e-8 Platelet distribution width; CRC cis rs490234 0.676 rs4838263 chr9:128225199 G/A cg14078157 chr9:128172775 NA -0.36 -6.0 -0.31 5.27e-9 Mean arterial pressure; CRC cis rs12594515 0.967 rs67854274 chr15:45990518 A/G cg06207120 chr15:45996521 NA 0.32 7.75 0.39 1.14e-13 Waist circumference;Weight; CRC cis rs7246865 0.859 rs7252102 chr19:17197012 A/G cg19418318 chr19:17219073 MYO9B 0.49 8.23 0.41 4.53e-15 Reticulocyte fraction of red cells; CRC cis rs13108904 0.901 rs13119532 chr4:1304505 G/C cg16405210 chr4:1374714 KIAA1530 -0.42 -5.78 -0.3 1.76e-8 Obesity-related traits; CRC cis rs9534288 0.797 rs9526134 chr13:46618046 G/T cg15192986 chr13:46630673 CPB2 -0.67 -9.67 -0.47 1.28e-19 Blood protein levels; CRC cis rs812925 0.537 rs778153 chr2:61608652 A/G cg10580144 chr2:61372316 C2orf74 -0.33 -7.38 -0.38 1.26e-12 Immature fraction of reticulocytes; CRC cis rs7524258 0.903 rs4908609 chr1:7292910 G/A cg07173049 chr1:7289937 CAMTA1 0.67 10.67 0.51 4.99e-23 Tourette's syndrome or obsessive-compulsive disorder; CRC trans rs1005277 0.579 rs2103938 chr10:38493998 T/G cg17830980 chr10:43048298 ZNF37B -0.57 -9.64 -0.47 1.61e-19 Extrinsic epigenetic age acceleration; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg20203792 chr4:20701925 PACRGL 0.48 6.15 0.32 2.25e-9 Thyroid stimulating hormone; CRC cis rs79349575 0.721 rs1008834 chr17:46968008 G/C cg00947319 chr17:47005597 UBE2Z -0.33 -5.7 -0.3 2.6e-8 Type 2 diabetes; CRC cis rs1865760 0.566 rs9295688 chr6:26084217 G/A cg17691542 chr6:26056736 HIST1H1C 0.54 8.16 0.41 7.07e-15 Height; CRC cis rs55788414 0.932 rs28514797 chr16:81185070 G/A cg06400318 chr16:81190750 PKD1L2 -0.59 -6.76 -0.35 6.2e-11 Left ventricular obstructive tract defect (maternal effect); CRC cis rs10504229 0.774 rs72650880 chr8:58164727 C/T cg11062466 chr8:58055876 NA 0.49 6.17 0.32 1.97e-9 Developmental language disorder (linguistic errors); CRC cis rs4862750 1.000 rs4862750 chr4:187904043 C/T cg03452623 chr4:187889614 NA -0.95 -21.81 -0.77 7.06e-66 Lobe attachment (rater-scored or self-reported); CRC cis rs10504229 0.683 rs11787247 chr8:58131528 G/T cg22535103 chr8:58192502 C8orf71 -0.7 -9.34 -0.46 1.47e-18 Developmental language disorder (linguistic errors); CRC cis rs12422267 0.536 rs12303484 chr12:132609558 G/A cg09764611 chr12:132620959 NA -0.61 -8.23 -0.41 4.39e-15 Plasma amyloid beta peptide concentrations (ABx-40); CRC cis rs2032447 0.736 rs115810 chr6:25975883 G/C cg03264133 chr6:25882463 NA -0.56 -7.63 -0.39 2.57e-13 Intelligence (multi-trait analysis); CRC cis rs7772172 0.502 rs2237166 chr6:16647158 C/T cg26843612 chr6:16636157 ATXN1 0.43 6.63 0.34 1.37e-10 Educational attainment (years of education); CRC cis rs4780401 0.609 rs9924522 chr16:11816852 C/A cg01061890 chr16:11836724 TXNDC11 -0.62 -9.25 -0.45 2.96e-18 Rheumatoid arthritis; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg05421555 chr15:85924342 AKAP13 0.45 7.43 0.38 9.36e-13 Liver disease severity in Alagille syndrome; CRC cis rs7119 0.651 rs35657172 chr15:77847813 T/C cg10437265 chr15:77819839 NA 0.59 9.97 0.48 1.23e-20 Type 2 diabetes; CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg02539911 chr17:58677246 PPM1D -0.6 -7.22 -0.37 3.57e-12 Diisocyanate-induced asthma; CRC cis rs6951245 1.000 rs77868187 chr7:1093968 A/C cg22907277 chr7:1156413 C7orf50 0.73 7.7 0.39 1.59e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs10504229 1.000 rs949848 chr8:58169125 A/G cg05313129 chr8:58192883 C8orf71 -0.47 -7.28 -0.37 2.55e-12 Developmental language disorder (linguistic errors); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg17819963 chr10:135191943 PAOX 0.4 7.06 0.36 1.02e-11 Liver disease severity in Alagille syndrome; CRC cis rs11971779 0.680 rs4728465 chr7:139069061 G/A cg07862535 chr7:139043722 LUC7L2 0.82 10.66 0.51 5.69e-23 Diisocyanate-induced asthma; CRC cis rs16852403 0.861 rs73049336 chr1:178042298 A/T cg00404053 chr1:178313656 RASAL2 0.48 6.03 0.32 4.46e-9 Childhood ear infection; CRC cis rs637571 0.522 rs679581 chr11:65746653 A/G cg26695010 chr11:65641043 EFEMP2 -0.39 -5.85 -0.31 1.19e-8 Eosinophil percentage of white cells; CRC cis rs7811142 0.830 rs11769057 chr7:99964661 A/G cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.61 7.95 0.4 3e-14 Platelet count; CRC cis rs9768139 0.935 rs10949715 chr7:158117246 G/T cg23298862 chr7:158159286 PTPRN2 0.47 7.66 0.39 2.16e-13 Calcium levels; CRC cis rs4481887 0.927 rs10788779 chr1:248481661 C/G cg00666640 chr1:248458726 OR2T12 0.47 7.99 0.4 2.29e-14 Common traits (Other); CRC cis rs2180341 0.694 rs2875972 chr6:127585522 T/C cg27446573 chr6:127587934 RNF146 0.81 11.96 0.55 1.24e-27 Breast cancer; CRC cis rs9916302 0.706 rs9906612 chr17:37547631 A/C cg07936489 chr17:37558343 FBXL20 0.92 11.73 0.54 8.63e-27 Glomerular filtration rate (creatinine); CRC cis rs6952808 0.698 rs11765639 chr7:1986738 G/A cg21782813 chr7:2030301 MAD1L1 0.49 7.89 0.4 4.4e-14 Bipolar disorder and schizophrenia; CRC trans rs1005277 0.579 rs2472182 chr10:38388865 T/C cg23533926 chr12:111358616 MYL2 -0.52 -7.84 -0.4 6.17e-14 Extrinsic epigenetic age acceleration; CRC cis rs4474465 0.790 rs4945293 chr11:78254554 T/C cg27205649 chr11:78285834 NARS2 0.52 6.67 0.34 1.11e-10 Alzheimer's disease (survival time); CRC cis rs7212938 0.509 rs3893044 chr17:38103016 C/T cg24910161 chr17:38119198 GSDMA 0.45 7.97 0.4 2.58e-14 Asthma and hay fever; CRC cis rs6456156 0.711 rs1855025 chr6:167537594 A/G cg19688584 chr6:167529678 CCR6 -0.34 -6.32 -0.33 8.63e-10 Primary biliary cholangitis; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg07133894 chr22:32808171 C22orf28 0.49 6.75 0.35 6.5500000000000006e-11 Response to antipsychotic treatment; CRC cis rs4423214 0.959 rs12800438 chr11:71171003 G/A cg05163923 chr11:71159392 DHCR7 0.66 9.38 0.46 1.13e-18 Vitamin D levels; CRC cis rs317689 0.718 rs315122 chr12:69771073 G/T cg14784868 chr12:69753453 YEATS4 0.56 7.03 0.36 1.19e-11 Response to diuretic therapy; CRC cis rs801193 0.569 rs3846973 chr7:66120035 T/C cg00343986 chr7:65444356 GUSB -0.45 -6.2 -0.32 1.7e-9 Aortic root size; CRC cis rs875971 0.929 rs12535036 chr7:65964063 G/T cg18912574 chr7:65842487 NCRNA00174 0.35 6.09 0.32 3.11e-9 Aortic root size; CRC cis rs75804782 0.641 rs72985397 chr2:239341354 A/G cg18131467 chr2:239335373 ASB1 -0.69 -6.22 -0.32 1.52e-9 Morning vs. evening chronotype;Chronotype; CRC cis rs6951245 1.000 rs113858334 chr7:1073476 A/G cg04025307 chr7:1156635 C7orf50 0.63 6.63 0.34 1.41e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs45430 1.000 rs408825 chr21:42743496 A/G cg22778903 chr21:42741698 MX2 -0.42 -7.15 -0.37 5.68e-12 Melanoma; CRC cis rs11148252 0.538 rs2408609 chr13:52714043 C/T cg02158880 chr13:53174818 NA 0.4 5.63 0.3 3.91e-8 Lewy body disease; CRC cis rs1448094 0.511 rs17279289 chr12:86162792 T/G cg25456477 chr12:86230367 RASSF9 0.38 6.43 0.33 4.41e-10 Major depressive disorder; CRC cis rs9322193 0.923 rs1112729 chr6:150087627 C/A cg13206674 chr6:150067644 NUP43 0.57 8.19 0.41 5.85e-15 Lung cancer; CRC cis rs11585357 0.843 rs113593167 chr1:17613355 G/A cg08277548 chr1:17600880 PADI3 -0.9 -11.44 -0.53 1e-25 Hair shape; CRC cis rs6424115 0.679 rs2294495 chr1:24075876 C/T cg15997130 chr1:24165203 NA -0.65 -8.12 -0.41 9.74e-15 Immature fraction of reticulocytes; CRC cis rs4713118 0.662 rs149946 chr6:27970031 A/C cg25164649 chr6:28176230 NA -0.66 -9.15 -0.45 6.32e-18 Parkinson's disease; CRC cis rs910316 0.687 rs11627442 chr14:75669649 A/G cg08847533 chr14:75593920 NEK9 -0.75 -11.86 -0.55 3.06e-27 Height; CRC cis rs4713118 0.955 rs9468200 chr6:27683063 T/A cg12273811 chr6:28175739 NA 0.54 7.21 0.37 3.86e-12 Parkinson's disease; CRC cis rs875971 0.545 rs316305 chr7:65617971 G/A cg11764359 chr7:65958608 NA -0.47 -5.92 -0.31 8e-9 Aortic root size; CRC cis rs6951245 1.000 rs11763835 chr7:1094513 A/G cg26224354 chr7:1096374 C7orf50;GPR146 -0.93 -12.14 -0.56 2.81e-28 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs116095464 0.558 rs56081398 chr5:247318 C/T cg22857025 chr5:266934 NA -1.16 -12.12 -0.56 3.3e-28 Breast cancer; CRC trans rs7604735 0.824 rs1881410 chr2:145821717 C/T cg26010734 chr19:15344046 EPHX3 -0.35 -6.08 -0.32 3.34e-9 Coronary artery disease; CRC cis rs7726839 0.540 rs3762951 chr5:662613 C/G cg09021430 chr5:549028 NA -0.71 -7.94 -0.4 3.27e-14 Obesity-related traits; CRC cis rs2276314 1.000 rs58054756 chr18:33554053 G/C cg19628046 chr18:33552617 C18orf21 0.47 6.51 0.34 2.73e-10 Endometriosis;Drug-induced torsades de pointes; CRC cis rs4689388 0.824 rs4467645 chr4:6294305 C/T cg25554036 chr4:6271136 WFS1 0.53 8.7 0.43 1.59e-16 Type 2 diabetes and other traits;Type 2 diabetes; CRC trans rs3780486 0.718 rs10971418 chr9:33122024 A/C cg20290983 chr6:43655470 MRPS18A -0.96 -12.69 -0.57 2.6e-30 IgG glycosylation; CRC cis rs13191362 1.000 rs55822577 chr6:163069710 G/A cg14584255 chr6:163149320 PACRG;PARK2 0.44 6.36 0.33 6.71e-10 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs3785574 0.745 rs2854162 chr17:61975610 T/C cg06601766 chr17:61851465 DDX42;CCDC47 -0.61 -8.32 -0.42 2.39e-15 Height; CRC cis rs10504229 0.953 rs75585481 chr8:58192202 T/C cg02290350 chr8:58132656 NA -0.42 -5.96 -0.31 6.62e-9 Developmental language disorder (linguistic errors); CRC cis rs4713118 0.513 rs202908 chr6:28011551 C/G cg06470822 chr6:28175283 NA 0.8 11.92 0.55 1.78e-27 Parkinson's disease; CRC cis rs7264396 0.563 rs2425103 chr20:34312329 G/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.49 -6.77 -0.35 6.03e-11 Total cholesterol levels; CRC cis rs1552244 1.000 rs6764068 chr3:10153842 A/G cg02579736 chr3:10068473 FANCD2;CIDECP 1.03 13.5 0.6 2.34e-33 Alzheimer's disease; CRC cis rs9325144 0.513 rs12313652 chr12:38665412 G/A cg13010199 chr12:38710504 ALG10B -0.42 -6.11 -0.32 2.75e-9 Morning vs. evening chronotype; CRC cis rs17376456 0.825 rs6874766 chr5:93213807 C/G cg21475434 chr5:93447410 FAM172A -0.8 -7.69 -0.39 1.67e-13 Diabetic retinopathy; CRC cis rs11711311 1.000 rs12736 chr3:113530211 T/C cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.52 -7.18 -0.37 4.76e-12 IgG glycosylation; CRC cis rs6952808 0.792 rs2056478 chr7:1953897 C/T cg22963979 chr7:1858916 MAD1L1 -0.51 -7.53 -0.38 4.97e-13 Bipolar disorder and schizophrenia; CRC trans rs6952808 0.510 rs13227554 chr7:2048220 G/C cg04565464 chr8:145669602 NFKBIL2 -0.43 -6.58 -0.34 1.82e-10 Bipolar disorder and schizophrenia; CRC cis rs113835537 0.866 rs59320108 chr11:66365996 A/T cg22134325 chr11:66188745 NPAS4 0.4 6.43 0.33 4.49e-10 Airway imaging phenotypes; CRC cis rs7224685 0.501 rs812996 chr17:3965674 T/C cg21851534 chr17:3907994 ZZEF1 0.37 6.41 0.33 5.16e-10 Type 2 diabetes; CRC cis rs77861329 1.000 rs9841469 chr3:52166596 C/A cg08692210 chr3:52188851 WDR51A 0.86 7.84 0.4 6.46e-14 Macrophage inflammatory protein 1b levels; CRC cis rs6502050 0.842 rs9894129 chr17:80075700 A/G cg19223190 chr17:80058835 NA -0.41 -6.56 -0.34 2.07e-10 Life satisfaction; CRC cis rs6088813 1.000 rs56306402 chr20:33937704 G/A cg14752227 chr20:34000481 UQCC -0.37 -5.73 -0.3 2.3e-8 Height; CRC cis rs7666738 0.819 rs13139560 chr4:99081188 C/T cg05340658 chr4:99064831 C4orf37 0.51 6.41 0.33 5.02e-10 Colonoscopy-negative controls vs population controls; CRC cis rs1552244 1.000 rs9824585 chr3:10114802 T/C cg16606324 chr3:10149918 C3orf24 0.7 9.64 0.47 1.61e-19 Alzheimer's disease; CRC cis rs10782582 0.569 rs2131557 chr1:76388589 A/C cg10523679 chr1:76189770 ACADM 0.4 5.65 0.3 3.47e-8 Daytime sleep phenotypes; CRC cis rs10751667 0.666 rs7943140 chr11:973824 T/C ch.11.42038R chr11:967971 AP2A2 0.58 10.03 0.48 7.98e-21 Alzheimer's disease (late onset); CRC cis rs78456975 0.600 rs72776256 chr2:1529595 C/A cg26248373 chr2:1572462 NA -0.63 -6.64 -0.34 1.29e-10 Placebo response in major depressive disorder (% change in symptom score); CRC cis rs1580019 0.539 rs11769109 chr7:32571352 A/G cg07520158 chr7:32535189 LSM5;AVL9 0.54 7.94 0.4 3.18e-14 Cognitive ability; CRC trans rs11343 0.675 rs7359333 chr16:19262344 A/T cg20999565 chr14:68265668 ZFYVE26 -0.54 -7.07 -0.36 9.14e-12 Parkinson's disease; CRC cis rs2549003 1.000 rs2070725 chr5:131821788 C/T cg00255919 chr5:131827918 IRF1 0.59 11.92 0.55 1.77e-27 Asthma (sex interaction); CRC cis rs10883723 0.810 rs12265877 chr10:104247247 C/G cg04362960 chr10:104952993 NT5C2 -0.43 -6.02 -0.32 4.58e-9 Allergic disease (asthma, hay fever or eczema); CRC cis rs736801 0.808 rs4705950 chr5:131793286 C/T cg02033258 chr5:131593261 PDLIM4 0.34 6.0 0.31 5.11e-9 Breast cancer;Mosquito bite size; CRC cis rs6089584 0.566 rs2146852 chr20:60616492 T/G cg23262073 chr20:60523788 NA -0.41 -6.57 -0.34 2e-10 Body mass index; CRC cis rs10504229 0.815 rs55855654 chr8:58164299 T/G cg02725872 chr8:58115012 NA -0.59 -9.08 -0.45 1.02e-17 Developmental language disorder (linguistic errors); CRC cis rs12142240 0.698 rs7548675 chr1:46809321 C/G cg14993813 chr1:46806288 NSUN4 -0.49 -6.22 -0.32 1.5e-9 Menopause (age at onset); CRC cis rs875971 0.545 rs12670811 chr7:65823019 C/A cg18876405 chr7:65276391 NA 0.45 6.27 0.33 1.11e-9 Aortic root size; CRC trans rs7726839 0.561 rs4957049 chr5:579080 C/A cg25482853 chr8:67687455 SGK3 1.01 12.23 0.56 1.28e-28 Obesity-related traits; CRC cis rs853679 0.527 rs853690 chr6:28285482 G/A cg06470822 chr6:28175283 NA 0.48 6.68 0.35 1.02e-10 Depression; CRC cis rs9894429 1.000 rs7222241 chr17:79574714 C/G cg21028142 chr17:79581711 NPLOC4 0.4 8.87 0.44 4.76e-17 Eye color traits; CRC cis rs4654899 0.802 rs12401413 chr1:21236503 T/C cg02927042 chr1:21476669 EIF4G3 -0.5 -7.96 -0.4 2.78e-14 Superior frontal gyrus grey matter volume; CRC cis rs3617 0.573 rs62253582 chr3:52928333 G/A cg15147215 chr3:52552868 STAB1 0.5 8.61 0.43 3.13e-16 Red blood cell count;Autism spectrum disorder or schizophrenia; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg26546504 chr18:54318490 WDR7 0.45 6.25 0.33 1.29e-9 Anxiety disorder; CRC cis rs7208859 0.623 rs7503542 chr17:29073830 A/C cg01831904 chr17:28903510 LRRC37B2 -0.62 -6.39 -0.33 5.8e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs6903823 0.508 rs1150721 chr6:28255040 G/C cg21251018 chr6:28226885 NKAPL 0.55 9.43 0.46 7.66e-19 Pulmonary function; CRC cis rs6834538 0.655 rs4428348 chr4:113423989 G/A cg10021238 chr4:113569128 MIR367;LARP7 -0.39 -5.79 -0.3 1.67e-8 Free thyroxine concentration; CRC cis rs1044826 0.642 rs6787649 chr3:139193321 C/T cg15131784 chr3:139108705 COPB2 0.4 5.78 0.3 1.76e-8 Obesity-related traits; CRC cis rs6429082 0.818 rs291381 chr1:235641924 A/G cg26050004 chr1:235667680 B3GALNT2 0.58 7.96 0.4 2.87e-14 Adiposity; CRC cis rs9341808 0.935 rs9343974 chr6:80924645 A/G cg08355045 chr6:80787529 NA 0.37 6.11 0.32 2.79e-9 Sitting height ratio; CRC cis rs7666738 0.830 rs28785514 chr4:98959135 G/A cg17366294 chr4:99064904 C4orf37 0.43 7.34 0.38 1.69e-12 Colonoscopy-negative controls vs population controls; CRC cis rs13256369 1.000 rs9329166 chr8:8576655 C/T cg06671706 chr8:8559999 CLDN23 0.6 8.31 0.42 2.62e-15 Obesity-related traits; CRC trans rs7618501 1.000 rs6446295 chr3:49809063 G/T cg21659725 chr3:3221576 CRBN 0.9 17.3 0.69 3.92e-48 Intelligence (multi-trait analysis); CRC cis rs736408 0.609 rs62255396 chr3:52782839 C/T cg10802521 chr3:52805072 NEK4 -0.58 -8.87 -0.44 4.88e-17 Bipolar disorder; CRC cis rs4523957 0.890 rs9900379 chr17:2101134 G/A cg16513277 chr17:2031491 SMG6 -0.5 -8.16 -0.41 6.96e-15 Autism spectrum disorder or schizophrenia;Schizophrenia; CRC cis rs10751667 0.560 rs7924794 chr11:962745 A/T cg06064525 chr11:970664 AP2A2 -0.3 -6.07 -0.32 3.46e-9 Alzheimer's disease (late onset); CRC cis rs6582630 0.638 rs12425531 chr12:38550387 A/G cg26384229 chr12:38710491 ALG10B -0.52 -7.56 -0.38 4.18e-13 Drug-induced liver injury (flucloxacillin); CRC cis rs1878931 0.582 rs10048083 chr16:3417465 A/C cg26668626 chr16:3451006 ZNF174;ZNF434 0.54 6.9 0.36 2.63e-11 Body mass index (adult); CRC cis rs2576037 0.526 rs7234570 chr18:44459656 A/G cg23996704 chr18:44553084 KATNAL2 -0.35 -7.24 -0.37 3.1e-12 Personality dimensions; CRC cis rs13064411 0.696 rs6786974 chr3:113190149 T/A cg18753928 chr3:113234510 CCDC52 -0.7 -10.88 -0.51 9.38e-24 Response to simvastatin treatment (PCSK9 protein level change); CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg23182539 chr10:121355708 TIAL1 -0.53 -6.52 -0.34 2.67e-10 Diisocyanate-induced asthma; CRC cis rs10876993 0.928 rs7136269 chr12:58075937 G/A cg15848620 chr12:58087721 OS9 -0.61 -8.38 -0.42 1.61e-15 Celiac disease or Rheumatoid arthritis; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg19683457 chr6:105307726 HACE1 -0.45 -6.72 -0.35 8.17e-11 Myopia (pathological); CRC trans rs12200782 0.649 rs4490658 chr6:26385113 A/G cg25800765 chr12:85673347 ALX1 0.26 5.96 0.31 6.54e-9 Small cell lung carcinoma; CRC cis rs12550646 0.652 rs12680139 chr8:41666355 G/T cg12180191 chr8:41686706 ANK1 -0.4 -5.88 -0.31 9.94e-9 Reticulocyte fraction of red cells;Reticulocyte count; CRC cis rs9457247 1.000 rs2149085 chr6:167371110 T/C cg23791538 chr6:167370224 RNASET2 0.39 6.0 0.31 5.34e-9 Crohn's disease; CRC cis rs3806843 0.576 rs246072 chr5:140320426 C/T cg19875535 chr5:140030758 IK 0.39 6.02 0.32 4.55e-9 Depressive symptoms (multi-trait analysis); CRC cis rs4665809 1.000 rs7573118 chr2:26308086 A/G cg25036284 chr2:26402008 FAM59B -0.46 -6.03 -0.32 4.3e-9 Gut microbiome composition (summer); CRC cis rs2836974 0.932 rs35571600 chr21:40590624 A/C cg17971929 chr21:40555470 PSMG1 0.84 12.13 0.56 2.95e-28 Cognitive function; CRC cis rs10512697 0.772 rs35155570 chr5:3518273 C/T cg19473799 chr5:3511975 NA -0.85 -6.62 -0.34 1.44e-10 Immune response to smallpox vaccine (IL-6); CRC cis rs11585357 1.000 rs11203346 chr1:17600822 A/G cg08277548 chr1:17600880 PADI3 -0.95 -12.92 -0.58 3.6e-31 Hair shape; CRC cis rs17152411 0.895 rs7079153 chr10:126587146 C/G cg07906193 chr10:126599966 NA 0.56 6.43 0.33 4.37e-10 Height; CRC cis rs9660992 0.573 rs4400674 chr1:205218425 A/C cg21643547 chr1:205240462 TMCC2 0.39 6.31 0.33 8.89e-10 Mean corpuscular volume;Mean platelet volume; CRC cis rs6502050 0.835 rs8067875 chr17:80092778 C/T cg09264619 chr17:80180166 NA -0.35 -5.86 -0.31 1.13e-8 Life satisfaction; CRC trans rs11098499 0.644 rs3986377 chr4:120260270 G/A cg25214090 chr10:38739885 LOC399744 0.55 9.0 0.44 1.84e-17 Corneal astigmatism; CRC cis rs45544231 0.544 rs8052175 chr16:52577142 C/T cg09051775 chr16:52580266 TOX3 -0.4 -6.37 -0.33 6.42e-10 Restless legs syndrome; CRC cis rs6502050 0.835 rs7503111 chr17:80101587 A/T cg19223190 chr17:80058835 NA 0.4 6.36 0.33 6.88e-10 Life satisfaction; CRC cis rs6964587 0.967 rs55801687 chr7:91762629 C/A cg17063962 chr7:91808500 NA 0.84 14.74 0.63 4.12e-38 Breast cancer; CRC cis rs1005277 0.579 rs2103938 chr10:38493998 T/G cg25517755 chr10:38738941 LOC399744 -0.4 -5.9 -0.31 9.11e-9 Extrinsic epigenetic age acceleration; CRC cis rs11098499 0.722 rs10006192 chr4:120263022 T/C cg09307838 chr4:120376055 NA 0.61 9.66 0.47 1.33e-19 Corneal astigmatism; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg08165151 chr6:88411075 NCRNA00120;AKIRIN2 0.43 6.07 0.32 3.6e-9 Intelligence (multi-trait analysis); CRC cis rs208520 0.690 rs12198745 chr6:66722598 T/C cg07460842 chr6:66804631 NA 0.98 13.68 0.6 5.03e-34 Exhaled nitric oxide output; CRC cis rs3996993 0.809 rs12524918 chr6:52736180 T/C cg20803780 chr6:52668592 GSTA1 0.37 6.85 0.35 3.6e-11 Hemoglobin concentration; CRC cis rs7246967 0.604 rs58653025 chr19:22941617 T/C cg08271804 chr19:22816896 ZNF492 0.38 5.85 0.31 1.2e-8 Bronchopulmonary dysplasia; CRC cis rs17539620 0.624 rs62432746 chr6:154838986 A/G cg20019720 chr6:154832845 CNKSR3 0.5 8.13 0.41 8.79e-15 Lipoprotein (a) levels; CRC cis rs9517320 1.000 rs7338549 chr13:99142745 C/T cg20487152 chr13:99095054 FARP1 0.35 5.7 0.3 2.72e-8 Longevity; CRC cis rs7829975 0.533 rs1039917 chr8:8718850 C/T cg08975724 chr8:8085496 FLJ10661 0.38 5.67 0.3 3.14e-8 Mood instability; CRC cis rs17270561 0.609 rs4145217 chr6:25743997 T/C cg17691542 chr6:26056736 HIST1H1C 0.72 9.24 0.45 3.07e-18 Iron status biomarkers; CRC cis rs9611519 0.894 rs4821998 chr22:41468273 C/G cg06634786 chr22:41940651 POLR3H -0.44 -5.7 -0.3 2.66e-8 Neuroticism; CRC cis rs17270561 0.943 rs76703022 chr6:25703529 A/C cg16482183 chr6:26056742 HIST1H1C 0.72 7.98 0.4 2.5e-14 Iron status biomarkers; CRC cis rs802075 1.000 rs360565 chr6:49657805 C/T cg20364632 chr6:49636226 NA -0.36 -5.88 -0.31 9.95e-9 Bone mineral density (hip) and age at menarche; CRC cis rs9894429 1.000 rs7503679 chr17:79583843 G/C cg13777783 chr17:79615861 NA -0.3 -5.72 -0.3 2.44e-8 Eye color traits; CRC cis rs7781266 0.500 rs2971975 chr7:133645355 G/A cg03336402 chr7:133662267 EXOC4 -0.67 -10.46 -0.5 2.65e-22 Educational attainment (college completion); CRC cis rs56283067 0.847 rs10456535 chr6:44692758 G/A cg18551225 chr6:44695536 NA -0.41 -5.95 -0.31 6.68e-9 Total body bone mineral density; CRC cis rs11711311 0.955 rs9813630 chr3:113377361 A/G cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.52 -7.01 -0.36 1.37e-11 IgG glycosylation; CRC cis rs939658 0.805 rs34222382 chr15:79440748 C/T cg17916960 chr15:79447300 NA -0.45 -7.32 -0.37 1.86e-12 Refractive error; CRC trans rs61931739 0.500 rs11053197 chr12:34441949 C/T cg26384229 chr12:38710491 ALG10B 0.67 8.86 0.44 5.18e-17 Morning vs. evening chronotype; CRC cis rs9322193 0.884 rs9322210 chr6:150016576 G/A cg00933542 chr6:150070202 PCMT1 0.29 5.96 0.31 6.41e-9 Lung cancer; CRC cis rs75920871 0.528 rs7108912 chr11:116925996 G/A cg20608306 chr11:116969690 SIK3 -0.34 -6.46 -0.34 3.86e-10 Subjective well-being; CRC cis rs2836974 1.000 rs12710454 chr21:40656919 A/G cg11644478 chr21:40555479 PSMG1 0.69 9.81 0.48 4.15e-20 Cognitive function; CRC cis rs12541635 0.967 rs4734896 chr8:107075454 T/C cg10147462 chr8:107024639 NA -0.38 -6.41 -0.33 5.1e-10 Age of smoking initiation; CRC cis rs950169 1.000 rs1848093 chr15:84755527 G/C cg17507749 chr15:85114479 UBE2QP1 0.77 11.92 0.55 1.78e-27 Schizophrenia; CRC cis rs2739330 0.828 rs2186366 chr22:24254113 A/G cg11905131 chr22:24372483 LOC391322 0.71 11.61 0.54 2.4e-26 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs6502050 0.865 rs74480314 chr17:80117716 C/T cg11859384 chr17:80120422 CCDC57 -0.37 -5.9 -0.31 8.99e-9 Life satisfaction; CRC cis rs2346177 0.874 rs35462976 chr2:46649049 A/G cg26688816 chr2:46740690 ATP6V1E2 -0.48 -7.18 -0.37 4.62e-12 HDL cholesterol; CRC trans rs61101201 0.962 rs10835790 chr11:31610022 C/T cg08301299 chr16:2317849 RNPS1 -0.52 -6.13 -0.32 2.51e-9 Optic disc area; CRC cis rs1129187 0.967 rs9462857 chr6:42943098 T/C cg21280719 chr6:42927975 GNMT -0.43 -9.45 -0.46 6.4e-19 Alzheimer's disease in APOE e4+ carriers; CRC cis rs6912958 0.515 rs381782 chr6:88040649 C/T cg12350822 chr6:88032061 C6orf162;GJB7 0.5 10.24 0.49 1.54e-21 Monocyte percentage of white cells; CRC trans rs60843830 1.000 rs7605824 chr2:280819 A/G cg11347411 chr7:150020925 ACTR3C;LRRC61 -0.61 -9.72 -0.47 8.23e-20 Spherical equivalent (joint analysis main effects and education interaction); CRC cis rs7927771 0.524 rs12226431 chr11:47805856 G/A cg20307385 chr11:47447363 PSMC3 0.46 6.59 0.34 1.7e-10 Subjective well-being; CRC cis rs990171 0.955 rs6734736 chr2:103062880 C/T cg03938978 chr2:103052716 IL18RAP 0.46 5.91 0.31 8.41e-9 Lymphocyte counts; CRC cis rs10504229 1.000 rs66840104 chr8:58190001 C/T cg01721255 chr8:58191610 C8orf71 0.49 6.17 0.32 2e-9 Developmental language disorder (linguistic errors); CRC cis rs6951245 1.000 rs79683221 chr7:1096139 A/G cg03188948 chr7:1209495 NA 0.66 6.94 0.36 2.04e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs968567 1.000 rs968567 chr11:61595564 C/T cg21709803 chr11:61594965 FADS2 -0.58 -6.8 -0.35 4.99e-11 Blood metabolite levels;Rheumatoid arthritis;Vitiligo;Glycerophospholipid levels; CRC cis rs8060686 0.641 rs11075665 chr16:68070774 C/T cg26727032 chr16:67993705 SLC12A4 -0.55 -6.4 -0.33 5.25e-10 HDL cholesterol;Metabolic syndrome; CRC cis rs2439831 0.867 rs496584 chr15:43831923 C/T cg15269541 chr15:43626905 ADAL -0.48 -5.84 -0.31 1.26e-8 Lung cancer in ever smokers; CRC cis rs908922 0.676 rs1001834 chr1:152495940 C/A cg23254163 chr1:152506842 NA 0.5 10.11 0.49 4.05e-21 Hair morphology; CRC cis rs597539 0.652 rs514833 chr11:68657734 C/T cg21963583 chr11:68658836 MRPL21 0.63 11.52 0.54 5.02e-26 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg25907053 chr2:70369816 NA 0.45 6.31 0.33 8.79e-10 Anxiety disorder; CRC cis rs3091242 0.900 rs669063 chr1:25721154 A/G cg20684491 chr1:25596433 NA 0.41 7.3 0.37 2.25e-12 Erythrocyte sedimentation rate; CRC cis rs10504229 0.683 rs56235637 chr8:58106008 T/C cg02290350 chr8:58132656 NA -0.59 -8.02 -0.4 1.88e-14 Developmental language disorder (linguistic errors); CRC cis rs881375 0.933 rs2239657 chr9:123671520 A/G cg09419670 chr9:123605666 PSMD5;LOC253039 -0.55 -8.07 -0.41 1.35e-14 Rheumatoid arthritis; CRC cis rs4920343 0.890 rs4920531 chr1:19095746 A/G cg19637330 chr1:19110922 NA -0.43 -6.51 -0.34 2.85e-10 Knee osteoarthritis; CRC cis rs7412746 0.658 rs7528773 chr1:150915875 G/A cg17724175 chr1:150552817 MCL1 0.44 6.69 0.35 9.45e-11 Melanoma; CRC cis rs10971721 0.822 rs72727341 chr9:33936876 C/A cg13495928 chr9:33750294 PRSS3 0.56 5.95 0.31 6.96e-9 Body mass index; CRC cis rs7044106 0.708 rs10984992 chr9:123473416 G/A cg09586646 chr9:123605570 PSMD5;LOC253039 0.63 9.18 0.45 4.87e-18 Hip circumference adjusted for BMI; CRC cis rs12477438 0.501 rs6753063 chr2:99801469 A/G cg26064155 chr2:99771622 LIPT1;TSGA10 0.87 15.96 0.66 7.31e-43 Chronic sinus infection; CRC cis rs7927771 0.832 rs896816 chr11:47394338 T/C cg05585544 chr11:47624801 NA 0.48 8.6 0.43 3.29e-16 Subjective well-being; CRC trans rs9329221 0.537 rs12678800 chr8:9978940 G/A cg06636001 chr8:8085503 FLJ10661 0.47 6.88 0.35 2.99e-11 Neuroticism; CRC cis rs4728302 0.608 rs10254118 chr7:133158353 T/A cg10665199 chr7:133106180 EXOC4 0.67 10.44 0.5 3.19e-22 Intelligence;Intelligence (multi-trait analysis); CRC cis rs12044355 0.827 rs11586191 chr1:231831781 G/C cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX 0.44 6.22 0.32 1.54e-9 Alzheimer's disease; CRC cis rs875971 0.862 rs778702 chr7:65864835 G/A cg18252515 chr7:66147081 NA -0.4 -5.88 -0.31 1e-8 Aortic root size; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg01881255 chr19:40950703 SERTAD3 0.49 7.3 0.37 2.2e-12 Response to antipsychotic treatment; CRC cis rs13256369 0.865 rs13282523 chr8:8577293 C/G cg00074818 chr8:8560427 CLDN23 0.32 5.88 0.31 9.95e-9 Obesity-related traits; CRC cis rs2976388 0.587 rs2717606 chr8:143799496 G/A cg22687807 chr8:143858763 LYNX1 0.51 8.97 0.44 2.24e-17 Urinary tract infection frequency; CRC trans rs4263408 0.934 rs9683743 chr4:39703194 A/C cg05755906 chr12:113623461 C12orf52;DDX54 -0.45 -6.38 -0.33 6.14e-10 Plasma amyloid beta peptide concentrations (ABx-40); CRC cis rs4843747 0.519 rs12599755 chr16:88107006 A/G cg03395651 chr16:88107091 BANP 0.6 7.76 0.39 1.12e-13 Menopause (age at onset); CRC cis rs8060686 0.545 rs12598630 chr16:68258852 T/G cg26727032 chr16:67993705 SLC12A4 -0.57 -6.22 -0.32 1.55e-9 HDL cholesterol;Metabolic syndrome; CRC cis rs3733585 0.806 rs7375599 chr4:9954918 C/T cg11266682 chr4:10021025 SLC2A9 0.51 10.66 0.51 5.62e-23 Cleft plate (environmental tobacco smoke interaction); CRC cis rs9486719 1.000 rs2499809 chr6:96870110 C/T cg06623918 chr6:96969491 KIAA0776 0.81 9.48 0.46 5.18e-19 Migraine;Coronary artery disease; CRC cis rs2050392 0.517 rs602966 chr10:30755853 C/T cg18806716 chr10:30721971 MAP3K8 -0.55 -7.65 -0.39 2.28e-13 Inflammatory bowel disease; CRC cis rs4654899 1.000 rs6426656 chr1:21343245 G/C cg02927042 chr1:21476669 EIF4G3 -0.48 -7.76 -0.39 1.09e-13 Superior frontal gyrus grey matter volume; CRC cis rs2836950 0.565 rs2836945 chr21:40596757 C/T cg11644478 chr21:40555479 PSMG1 -0.5 -7.44 -0.38 9.07e-13 Menarche (age at onset); CRC cis rs533581 0.866 rs2968474 chr16:88970566 A/G cg09141835 chr16:88988174 CBFA2T3 0.27 5.87 0.31 1.08e-8 Social autistic-like traits; CRC cis rs10751667 0.643 rs7942693 chr11:957832 G/A cg06064525 chr11:970664 AP2A2 -0.3 -6.22 -0.32 1.49e-9 Alzheimer's disease (late onset); CRC cis rs11122272 0.735 rs2247132 chr1:231493359 G/A cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.56 -8.34 -0.42 2.12e-15 Hemoglobin concentration; CRC cis rs7927771 0.965 rs35985502 chr11:47847428 G/A cg20307385 chr11:47447363 PSMC3 -0.49 -6.56 -0.34 2.04e-10 Subjective well-being; CRC cis rs4474465 0.915 rs12274873 chr11:78183015 C/G cg27205649 chr11:78285834 NARS2 -0.48 -5.94 -0.31 7.39e-9 Alzheimer's disease (survival time); CRC cis rs1218582 0.600 rs72702224 chr1:154911689 G/A cg24250549 chr1:154909240 PMVK 0.58 8.59 0.43 3.57e-16 Prostate cancer; CRC cis rs4363385 0.818 rs946096 chr1:153006529 T/A cg25856811 chr1:152973957 SPRR3 -0.25 -6.99 -0.36 1.51e-11 Inflammatory skin disease; CRC cis rs12291225 0.645 rs3763950 chr11:14278049 T/A cg19336497 chr11:14380999 RRAS2 -0.51 -8.4 -0.42 1.35e-15 Sense of smell; CRC cis rs1552244 0.572 rs3894322 chr3:10168965 G/A cg02579736 chr3:10068473 FANCD2;CIDECP 1.01 11.62 0.54 2.28e-26 Alzheimer's disease; CRC cis rs72615157 0.634 rs7789890 chr7:99800559 G/T cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.57 6.78 0.35 5.45e-11 Lung function (FEV1/FVC); CRC cis rs78456975 0.943 rs13385274 chr2:1576791 A/T cg26248373 chr2:1572462 NA -0.68 -8.31 -0.42 2.63e-15 Placebo response in major depressive disorder (% change in symptom score); CRC cis rs79057730 0.599 rs4720893 chr7:804434 G/A cg11064039 chr7:766100 PRKAR1B;HEATR2 0.69 6.74 0.35 7.28e-11 Initial pursuit acceleration; CRC cis rs1707322 1.000 rs10890353 chr1:46298383 G/T cg03146154 chr1:46216737 IPP 0.51 7.13 0.37 6.41e-12 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs10274279 0.660 rs4716760 chr7:157376644 A/G cg26886268 chr7:157387156 PTPRN2 0.46 6.49 0.34 3.17e-10 Myopia (pathological); CRC cis rs9787249 0.874 rs7520588 chr1:40214525 T/A cg24920358 chr1:40204285 PPIE 0.57 8.56 0.43 4.54e-16 Blood protein levels; CRC cis rs6504622 0.818 rs9898527 chr17:45036210 G/A cg16759221 chr17:45003025 GOSR2 -0.5 -7.47 -0.38 7.24e-13 Orofacial clefts; CRC cis rs35306767 0.855 rs12761180 chr10:872086 C/T cg26597838 chr10:835615 NA 1.25 15.13 0.64 1.26e-39 Eosinophil percentage of granulocytes; CRC cis rs1163251 0.837 rs660073 chr1:120245173 T/C cg19096424 chr1:120255104 PHGDH 0.41 5.85 0.31 1.16e-8 Blood metabolite levels; CRC trans rs75804782 0.641 rs56134361 chr2:239318905 A/G cg01134436 chr17:81009848 B3GNTL1 0.77 7.02 0.36 1.24e-11 Morning vs. evening chronotype;Chronotype; CRC cis rs2976388 0.609 rs2585149 chr8:143793320 T/C cg05569086 chr8:143859399 LYNX1 0.4 6.96 0.36 1.91e-11 Urinary tract infection frequency; CRC cis rs597539 0.616 rs631001 chr11:68642974 C/T cg21963583 chr11:68658836 MRPL21 0.64 11.21 0.53 6.38e-25 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs12586317 0.547 rs28569331 chr14:35473584 T/C cg16230307 chr14:35515116 FAM177A1 0.85 9.81 0.48 4.4e-20 Psoriasis; CRC trans rs2303319 0.504 rs1006427 chr2:162592328 T/C cg12500891 chr11:57225987 NA -0.65 -6.06 -0.32 3.77e-9 Cognitive function; CRC cis rs3733585 0.648 rs7378305 chr4:9954893 C/T cg11266682 chr4:10021025 SLC2A9 -0.47 -9.61 -0.47 1.9e-19 Cleft plate (environmental tobacco smoke interaction); CRC cis rs8180040 0.764 rs11716539 chr3:47186503 G/T cg10298567 chr3:47292165 KIF9 -0.38 -6.22 -0.32 1.47e-9 Colorectal cancer; CRC trans rs2795502 1.000 rs1581702 chr10:43344246 G/A cg06791473 chr12:49259579 RND1 -0.61 -6.05 -0.32 3.91e-9 Blood protein levels; CRC cis rs7927771 0.839 rs7124681 chr11:47529947 C/A cg18512352 chr11:47633146 NA -0.37 -7.32 -0.37 1.97e-12 Subjective well-being; CRC cis rs6540559 0.673 rs17015183 chr1:209948711 A/C cg23283495 chr1:209979779 IRF6 0.51 7.29 0.37 2.36e-12 Cleft lip with or without cleft palate; CRC cis rs17376456 0.877 rs35075119 chr5:93385457 T/C cg21475434 chr5:93447410 FAM172A 0.72 7.73 0.39 1.31e-13 Diabetic retinopathy; CRC cis rs763121 0.853 rs11704021 chr22:39074716 G/A cg06022373 chr22:39101656 GTPBP1 0.79 12.29 0.56 7.65e-29 Menopause (age at onset); CRC cis rs2019137 0.936 rs3828189 chr2:113954496 T/A cg12889195 chr2:113992843 PAX8;LOC440839;LOC654433 -0.5 -7.23 -0.37 3.48e-12 Lymphocyte counts; CRC cis rs9814567 1.000 rs6766818 chr3:134226159 C/T cg06109529 chr3:134205091 CEP63;ANAPC13 -0.82 -12.4 -0.56 3e-29 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs1878931 0.582 rs27225 chr16:3428060 G/A cg02880119 chr16:3481970 NA 0.43 6.05 0.32 3.91e-9 Body mass index (adult); CRC cis rs9488822 0.596 rs6568921 chr6:116373616 C/T cg18764771 chr6:116381957 FRK 0.25 6.8 0.35 4.83e-11 Cholesterol, total;LDL cholesterol; CRC cis rs9733 0.596 rs12085275 chr1:150650265 T/C cg18016565 chr1:150552671 MCL1 0.46 6.74 0.35 6.91e-11 Tonsillectomy; CRC cis rs9372498 0.536 rs9489442 chr6:118885950 A/C cg01339444 chr6:118972232 C6orf204 0.53 6.03 0.32 4.29e-9 Diastolic blood pressure; CRC cis rs2857078 0.720 rs9901595 chr17:42305699 G/A cg13607699 chr17:42295918 UBTF 0.76 13.03 0.58 1.46e-31 Red cell distribution width;Reticulocyte count; CRC cis rs11123610 0.520 rs11682697 chr2:3721127 A/G cg00999904 chr2:3704751 ALLC -0.53 -6.66 -0.34 1.15e-10 Response to inhaled corticosteroid treatment in asthma (change in FEV1); CRC cis rs294883 0.858 rs9347297 chr6:159702475 G/A cg14500486 chr6:159655392 FNDC1 -0.35 -5.75 -0.3 2.09e-8 Coronary artery disease; CRC cis rs4713118 0.527 rs9461433 chr6:28095172 C/T cg15786705 chr6:28176104 NA 0.77 9.75 0.47 6.92e-20 Parkinson's disease; CRC cis rs59104589 0.617 rs111937035 chr2:242212177 C/T cg19488206 chr2:242435732 STK25 0.49 7.07 0.36 9.41e-12 Fibrinogen levels; CRC cis rs6570726 0.791 rs401331 chr6:145831408 A/G cg23711669 chr6:146136114 FBXO30 0.74 12.86 0.58 5.93e-31 Lobe attachment (rater-scored or self-reported); CRC cis rs644799 0.965 rs565771 chr11:95644179 T/A cg03916912 chr11:95522834 CEP57;FAM76B 0.94 17.52 0.69 5.38e-49 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs6502050 0.761 rs12150321 chr17:80061558 T/C cg25804541 chr17:80189381 SLC16A3 0.32 5.98 0.31 5.75e-9 Life satisfaction; CRC cis rs6582630 0.531 rs3850000 chr12:38483752 T/C cg13010199 chr12:38710504 ALG10B 0.49 6.49 0.34 3.13e-10 Drug-induced liver injury (flucloxacillin); CRC cis rs12594515 1.000 rs6493170 chr15:45987019 G/A cg22117107 chr15:45993392 NA -0.45 -9.14 -0.45 6.79e-18 Waist circumference;Weight; CRC cis rs736408 0.609 rs2336545 chr3:52787603 C/T cg05573699 chr3:52720067 GNL3;PBRM1 0.45 6.47 0.34 3.47e-10 Bipolar disorder; CRC trans rs2303319 0.504 rs12470590 chr2:162493102 A/G cg13490827 chr1:46269305 MAST2 -0.72 -6.21 -0.32 1.56e-9 Cognitive function; CRC cis rs60871478 0.898 rs62432897 chr7:825429 A/G cg13844804 chr7:814759 HEATR2 0.68 8.14 0.41 8.45e-15 Cerebrospinal P-tau181p levels; CRC cis rs2243480 0.901 rs778693 chr7:65872345 T/G cg12463550 chr7:65579703 CRCP 0.7 6.26 0.33 1.22e-9 Diabetic kidney disease; CRC trans rs7937682 0.961 rs4936682 chr11:111629743 T/G cg18187862 chr3:45730750 SACM1L -0.53 -7.36 -0.38 1.5e-12 Primary sclerosing cholangitis; CRC cis rs427941 0.575 rs201520 chr7:101770677 G/A cg06246474 chr7:101738831 CUX1 0.37 5.66 0.3 3.27e-8 Plasma omega-3 polyunsaturated fatty acid level (eicosapentaenoic acid); CRC cis rs17376456 0.877 rs34673483 chr5:93315079 C/A cg25358565 chr5:93447407 FAM172A 1.05 10.89 0.51 8.72e-24 Diabetic retinopathy; CRC cis rs1348850 0.914 rs12693120 chr2:178283288 A/G cg02961200 chr2:178257176 LOC100130691;AGPS 0.63 9.15 0.45 6.03e-18 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs17376456 0.877 rs34673483 chr5:93315079 C/A cg09848695 chr5:92956644 FAM172A;MIR2277 0.64 5.92 0.31 8.24e-9 Diabetic retinopathy; CRC cis rs45544231 0.569 rs1362550 chr16:52582816 C/G cg09051775 chr16:52580266 TOX3 -0.42 -6.59 -0.34 1.77e-10 Restless legs syndrome; CRC cis rs7618915 0.508 rs7628578 chr3:52628321 A/T cg15147215 chr3:52552868 STAB1 -0.63 -10.7 -0.51 4.11e-23 Bipolar disorder; CRC cis rs11627756 0.801 rs4906237 chr14:103077649 T/G cg12046867 chr14:103022105 NA -0.44 -5.86 -0.31 1.13e-8 Mean platelet volume; CRC cis rs1949733 0.628 rs2688231 chr4:8490981 G/A cg13073564 chr4:8508604 NA -0.49 -7.6 -0.39 3.16e-13 Response to antineoplastic agents; CRC cis rs1799949 1.000 rs1960605 chr17:41305397 C/T cg23758822 chr17:41437982 NA 0.79 13.45 0.6 3.54e-33 Menopause (age at onset); CRC cis rs875971 0.798 rs57739047 chr7:65972566 A/T cg18252515 chr7:66147081 NA -0.42 -6.22 -0.32 1.55e-9 Aortic root size; CRC cis rs1046896 0.514 rs67735447 chr17:80823042 G/T cg17346650 chr17:80929145 B3GNTL1 0.48 7.24 0.37 3.26e-12 Glycated hemoglobin levels; CRC cis rs8060686 0.844 rs3785100 chr16:67997920 T/C cg26727032 chr16:67993705 SLC12A4 -0.59 -6.72 -0.35 7.96e-11 HDL cholesterol;Metabolic syndrome; CRC cis rs6546324 0.592 rs9309402 chr2:67869338 T/C cg15745817 chr2:67799979 NA -0.55 -9.54 -0.47 3.34e-19 Endometriosis; CRC cis rs72781680 0.898 rs12620558 chr2:23936022 G/A cg08917208 chr2:24149416 ATAD2B 0.99 9.37 0.46 1.21e-18 Lymphocyte counts; CRC cis rs9660180 1.000 rs3737628 chr1:1722932 C/T cg05132306 chr1:1846340 CALML6 -0.44 -6.86 -0.35 3.38e-11 Body mass index; CRC cis rs6684514 0.961 rs11264463 chr1:156242806 A/G cg16558208 chr1:156270281 VHLL 0.53 8.5 0.42 6.47e-16 Mean corpuscular hemoglobin concentration;Glycated hemoglobin levels; CRC cis rs11122272 0.735 rs910822 chr1:231498721 G/A cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.53 -8.16 -0.41 7.26e-15 Hemoglobin concentration; CRC cis rs6951245 0.935 rs11763765 chr7:1060510 C/T cg20603222 chr7:1096387 C7orf50;GPR146 -0.67 -7.81 -0.4 7.79e-14 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs1799949 1.000 rs35956818 chr17:41422985 T/C cg05368731 chr17:41323189 NBR1 0.67 10.08 0.49 5.26e-21 Menopause (age at onset); CRC cis rs4588572 0.601 rs10070202 chr5:77792462 A/C cg11547950 chr5:77652471 NA -0.57 -8.04 -0.41 1.68e-14 Triglycerides; CRC cis rs2243480 0.901 rs12530490 chr7:65691647 G/A cg18252515 chr7:66147081 NA 1.26 14.46 0.62 5.09e-37 Diabetic kidney disease; CRC cis rs6541297 0.941 rs6665258 chr1:230279058 G/A cg20703242 chr1:230279135 GALNT2 0.51 8.0 0.4 2.21e-14 Coronary artery disease; CRC cis rs7267979 0.844 rs869358 chr20:25374674 A/G cg24626310 chr20:25276739 ABHD12;PYGB -0.34 -5.75 -0.3 2.02e-8 Liver enzyme levels (alkaline phosphatase); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg02702510 chr10:46090551 MARCH8 0.45 6.26 0.33 1.2e-9 Response to antipsychotic treatment; CRC cis rs7614311 0.731 rs3774727 chr3:63977875 A/G cg22134162 chr3:63841271 THOC7 -0.56 -5.84 -0.31 1.24e-8 Lung function (FVC);Lung function (FEV1); CRC cis rs4074961 0.604 rs4411102 chr1:38063424 C/G cg13401533 chr1:37979913 MEAF6 0.44 6.23 0.32 1.42e-9 Axial length; CRC cis rs1707322 0.682 rs12041197 chr1:46104464 T/C cg03146154 chr1:46216737 IPP 0.67 9.75 0.47 6.55e-20 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs2806561 0.765 rs652783 chr1:23514313 G/T cg12483005 chr1:23474871 LUZP1 0.49 7.13 0.37 6.42e-12 Height; CRC cis rs12908161 1.000 rs12899981 chr15:85302373 G/A cg11189052 chr15:85197271 WDR73 0.58 8.43 0.42 1.1e-15 Schizophrenia; CRC cis rs13315871 0.929 rs34676912 chr3:58320298 C/A cg20936604 chr3:58311152 NA -0.77 -8.0 -0.4 2.15e-14 Cholesterol, total; CRC cis rs7914558 1.000 rs10509757 chr10:104752960 C/T cg04362960 chr10:104952993 NT5C2 0.6 9.13 0.45 7.14e-18 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs2976388 0.587 rs2717606 chr8:143799496 G/A cg20041105 chr8:143859282 LYNX1 0.46 8.12 0.41 9.33e-15 Urinary tract infection frequency; CRC cis rs873946 0.648 rs12782123 chr10:134554662 G/A cg06453172 chr10:134556979 INPP5A -0.69 -8.42 -0.42 1.18e-15 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg00558813 chr19:14063372 PODNL1;DCAF15 0.38 6.1 0.32 3.05e-9 Liver disease severity in Alagille syndrome; CRC cis rs7932354 0.528 rs4752962 chr11:47141670 C/G cg19486271 chr11:47235900 DDB2 0.49 7.16 0.37 5.34e-12 Bone mineral density (hip);Bone mineral density; CRC cis rs11098699 0.821 rs13148385 chr4:124206117 A/G cg09941581 chr4:124220074 SPATA5 0.4 5.87 0.31 1.08e-8 Mosquito bite size; CRC cis rs9649213 0.593 rs1468340 chr7:97987676 T/G cg00277769 chr7:97922759 BAIAP2L1 -0.6 -10.46 -0.5 2.68e-22 Prostate cancer (SNP x SNP interaction); CRC cis rs4242434 0.672 rs10099266 chr8:22484268 C/G cg03733263 chr8:22462867 KIAA1967 0.81 13.65 0.6 6.48e-34 Exploratory eye movement dysfunction in schizophrenia (cognitive search score); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg20975546 chr22:18893598 DGCR6 0.39 6.04 0.32 4.17e-9 Intelligence (multi-trait analysis); CRC cis rs2979489 0.838 rs2979513 chr8:30397925 G/C cg26383811 chr8:30366931 RBPMS -0.68 -9.95 -0.48 1.41e-20 Mean corpuscular hemoglobin;Plateletcrit;Neutrophil count;Granulocyte count;Sum basophil neutrophil counts;Mean corpuscular volume;Myeloid white cell count;Sum neutrophil eosinophil counts; CRC cis rs7705042 0.865 rs4385236 chr5:141513396 G/A cg08523384 chr5:141488047 NDFIP1 -0.31 -5.68 -0.3 3.02e-8 Asthma; CRC cis rs6502050 0.835 rs7502078 chr17:80131879 C/A cg02741985 chr17:80059408 CCDC57 0.44 7.29 0.37 2.38e-12 Life satisfaction; CRC cis rs2455601 0.608 rs11042104 chr11:8890924 C/G cg09997546 chr11:8931473 C11orf17;ST5 0.41 6.24 0.33 1.38e-9 Schizophrenia; CRC cis rs9467711 0.606 rs9366655 chr6:26377385 C/G cg16898833 chr6:26189333 HIST1H4D 0.75 6.38 0.33 5.93e-10 Autism spectrum disorder or schizophrenia; CRC cis rs7829975 0.742 rs1533059 chr8:8684953 A/G cg08975724 chr8:8085496 FLJ10661 -0.42 -6.25 -0.33 1.24e-9 Mood instability; CRC cis rs2019216 0.651 rs6565378 chr17:21831307 A/G cg05591447 chr17:21909280 FLJ36000 -0.31 -5.96 -0.31 6.38e-9 Pelvic organ prolapse; CRC cis rs1997103 1.000 rs6958022 chr7:55397389 G/A cg17469321 chr7:55412551 NA 0.74 11.4 0.53 1.38e-25 QRS interval (sulfonylurea treatment interaction); CRC cis rs6723226 0.721 rs3769600 chr2:32616879 G/A cg02381751 chr2:32503542 YIPF4 -0.53 -7.77 -0.39 1.03e-13 Intelligence (multi-trait analysis); CRC trans rs3942852 0.868 rs7122335 chr11:48106486 C/T cg15704280 chr7:45808275 SEPT13 -0.6 -6.89 -0.36 2.87e-11 Acute lymphoblastic leukemia (childhood); CRC cis rs741677 0.702 rs9893847 chr17:489043 C/G cg15660573 chr17:549704 VPS53 -0.44 -6.7 -0.35 8.83e-11 Waist circumference adjusted for body mass index;Waist circumference adjusted for BMI in active individuals;Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction); CRC cis rs6783573 0.510 rs11718490 chr3:46628763 C/T cg27371741 chr3:46619158 LRRC2;TDGF1 -0.42 -5.89 -0.31 9.67e-9 Cerebrospinal fluid biomarker levels; CRC cis rs875971 0.895 rs6460278 chr7:65662736 T/C cg11764359 chr7:65958608 NA -0.58 -8.64 -0.43 2.54e-16 Aortic root size; CRC cis rs798554 0.757 rs1182188 chr7:2869985 T/C cg14895029 chr7:2775587 GNA12 -0.4 -5.93 -0.31 7.82e-9 Height; CRC cis rs6951245 1.000 rs113858334 chr7:1073476 A/G cg18402987 chr7:1209562 NA 0.64 6.77 0.35 6.03e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs2153535 0.601 rs7775274 chr6:8530303 A/G cg07606381 chr6:8435919 SLC35B3 0.68 11.04 0.52 2.51e-24 Motion sickness; CRC cis rs734999 0.588 rs2764841 chr1:2529360 G/A cg20673091 chr1:2541236 MMEL1 -0.37 -5.81 -0.31 1.44e-8 Ulcerative colitis; CRC cis rs473651 0.935 rs520765 chr2:239354712 C/T cg08773314 chr2:239334832 ASB1 0.37 8.32 0.42 2.32e-15 Multiple system atrophy; CRC cis rs2404602 0.569 rs2469249 chr15:76772062 C/T cg03037974 chr15:76606532 NA -0.5 -6.95 -0.36 2.01e-11 Blood metabolite levels; CRC cis rs12580194 0.593 rs7959837 chr12:55734511 G/A cg19537932 chr12:55886519 OR6C68 -0.69 -8.71 -0.43 1.47e-16 Cancer; CRC cis rs832540 0.931 rs832529 chr5:56229288 C/T cg12311346 chr5:56204834 C5orf35 -0.51 -7.83 -0.4 6.75e-14 Coronary artery disease; CRC cis rs4478858 0.746 rs7544003 chr1:31689088 C/T cg00250761 chr1:31883323 NA 0.31 5.81 0.31 1.44e-8 Alcohol dependence; CRC cis rs12135062 0.851 rs2651927 chr1:3101762 A/C cg00254258 chr1:3105189 PRDM16 -0.54 -9.36 -0.46 1.25e-18 Migraine; CRC cis rs2019137 0.539 rs6755040 chr2:113981137 T/C cg21550016 chr2:113992930 PAX8;LOC440839;LOC654433 0.67 10.37 0.5 5.42e-22 Lymphocyte counts; CRC cis rs6502050 0.835 rs7405738 chr17:80084227 A/G cg09264619 chr17:80180166 NA 0.36 6.08 0.32 3.4e-9 Life satisfaction; CRC cis rs9894429 0.646 rs58398000 chr17:79576923 G/A cg21984481 chr17:79567631 NPLOC4 0.46 8.06 0.41 1.42e-14 Eye color traits; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg04078321 chr6:155635785 TFB1M 0.41 6.57 0.34 1.99e-10 Liver disease severity in Alagille syndrome; CRC cis rs896854 0.596 rs7823059 chr8:95974961 T/C cg09323728 chr8:95962352 TP53INP1 -0.45 -7.47 -0.38 7.48e-13 Type 2 diabetes; CRC cis rs17539620 0.624 rs111868524 chr6:154839960 G/C cg20019720 chr6:154832845 CNKSR3 0.5 8.01 0.4 1.96e-14 Lipoprotein (a) levels; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg20552752 chr15:90895281 ZNF774 0.51 7.56 0.38 3.96e-13 Response to antipsychotic treatment; CRC cis rs6120849 0.901 rs6058194 chr20:33739831 G/A cg24642439 chr20:33292090 TP53INP2 0.45 5.89 0.31 9.52e-9 Protein C levels; CRC trans rs8002861 0.935 rs4101376 chr13:44469835 C/T cg17145862 chr1:211918768 LPGAT1 -0.75 -15.44 -0.65 7.65e-41 Leprosy; CRC cis rs6499255 0.951 rs16958970 chr16:69627793 G/A cg15192750 chr16:69999425 NA 0.6 8.02 0.4 1.92e-14 IgE levels; CRC trans rs2727020 0.521 rs7126835 chr11:49594658 T/C cg15704280 chr7:45808275 SEPT13 -0.75 -10.05 -0.48 6.74e-21 Coronary artery disease; CRC cis rs798554 0.724 rs798498 chr7:2795882 T/G cg13628971 chr7:2884303 GNA12 0.54 7.9 0.4 4.17e-14 Height; CRC cis rs4481887 0.504 rs7544149 chr1:248360096 C/T cg00666640 chr1:248458726 OR2T12 0.44 7.07 0.36 9.39e-12 Common traits (Other); CRC cis rs35000415 0.938 rs71581958 chr7:128665542 C/T cg19972273 chr7:128594194 NA 0.68 6.32 0.33 8.52e-10 Systemic lupus erythematosus; CRC cis rs6570726 0.791 rs401561 chr6:145835917 G/T cg13319975 chr6:146136371 FBXO30 -0.44 -6.66 -0.34 1.13e-10 Lobe attachment (rater-scored or self-reported); CRC cis rs2411233 1.000 rs8034449 chr15:39278940 C/A cg23129342 chr15:39283510 NA 0.31 5.63 0.3 3.79e-8 Platelet count; CRC cis rs372883 0.530 rs55921835 chr21:30544623 A/G cg24692254 chr21:30365293 RNF160 -0.38 -5.61 -0.3 4.31e-8 Pancreatic cancer; CRC cis rs10078 0.515 rs6872510 chr5:481610 T/C cg07599136 chr5:415885 AHRR 0.72 6.99 0.36 1.52e-11 Fat distribution (HIV); CRC cis rs7953508 0.711 rs10492321 chr12:93980088 T/A cg18151635 chr12:93972918 NA -0.7 -9.69 -0.47 1.09e-19 Pubertal anthropometrics; CRC cis rs7640424 0.502 rs326359 chr3:107820619 G/A cg09227934 chr3:107805635 CD47 0.51 9.14 0.45 6.79e-18 Body mass index; CRC trans rs12495832 0.778 rs76487918 chr3:147926060 T/C cg10221266 chr7:153579447 NA 0.56 6.12 0.32 2.6e-9 Chin dimples; CRC cis rs459193 1.000 rs458741 chr5:55807837 T/C cg18302225 chr5:55776401 NA 0.58 8.6 0.43 3.38e-16 Coronary artery disease;Type 2 diabetes;Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);Waist-to-hip ratio adjusted for BMI in non-smokers;Waist-to-hip ratio adjusted for BMI (smoking interaction);Waist-to-hip ratio adjusted for body mass index;Waist-hip ratio;Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction); CRC cis rs6433857 0.594 rs10202422 chr2:181524944 C/T cg23363182 chr2:181467187 NA -0.47 -7.44 -0.38 9e-13 Body mass index; CRC cis rs12586317 0.547 rs10130773 chr14:35445299 G/A cg05294307 chr14:35346193 BAZ1A -0.71 -7.72 -0.39 1.41e-13 Psoriasis; CRC cis rs10540 0.570 rs8176330 chr11:535798 G/A cg21784768 chr11:537496 LRRC56 -0.72 -6.87 -0.35 3.26e-11 Body mass index; CRC cis rs4728302 0.869 rs11770927 chr7:133593126 G/A cg10665199 chr7:133106180 EXOC4 0.39 5.84 0.31 1.25e-8 Intelligence;Intelligence (multi-trait analysis); CRC cis rs60871478 1.000 rs35488064 chr7:812722 G/C cg05535760 chr7:792225 HEATR2 0.8 10.57 0.5 1.11e-22 Cerebrospinal P-tau181p levels; CRC cis rs11148252 0.740 rs7981050 chr13:52755149 C/T cg12458913 chr13:53173898 NA 0.5 7.48 0.38 6.78e-13 Lewy body disease; CRC cis rs7618915 0.547 rs11130314 chr3:52697082 T/C cg18099408 chr3:52552593 STAB1 -0.44 -7.22 -0.37 3.66e-12 Bipolar disorder; CRC cis rs4423214 0.840 rs1792235 chr11:71181473 C/T cg05163923 chr11:71159392 DHCR7 -0.64 -7.69 -0.39 1.71e-13 Vitamin D levels; CRC cis rs6502050 0.835 rs7218857 chr17:80161000 T/C cg22110888 chr17:80059540 CCDC57 0.38 6.07 0.32 3.61e-9 Life satisfaction; CRC cis rs7605827 0.930 rs2287263 chr2:15637366 C/T cg19274914 chr2:15703543 NA 0.38 5.81 0.3 1.5e-8 Educational attainment (years of education); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg08724901 chr15:89089781 DET1 0.46 6.41 0.33 5.14e-10 Response to antipsychotic treatment; CRC cis rs208515 0.525 rs9453538 chr6:66668508 G/A cg07460842 chr6:66804631 NA 0.96 12.07 0.55 5.02e-28 Exhaled nitric oxide levels; CRC cis rs68170813 0.599 rs77878465 chr7:106890996 G/A cg02696742 chr7:106810147 HBP1 -0.53 -6.01 -0.31 4.84e-9 Coronary artery disease; CRC cis rs9916302 0.800 rs8069451 chr17:37504933 C/T cg07936489 chr17:37558343 FBXL20 -0.81 -12.4 -0.56 3.07e-29 Glomerular filtration rate (creatinine); CRC cis rs597539 0.652 rs557625 chr11:68634722 G/A cg04772025 chr11:68637568 NA 0.51 8.11 0.41 1.04e-14 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs875971 0.545 rs4441996 chr7:65588220 T/C cg18876405 chr7:65276391 NA -0.44 -6.13 -0.32 2.51e-9 Aortic root size; CRC cis rs6502050 0.799 rs7406257 chr17:80089340 G/A cg19223190 chr17:80058835 NA 0.39 6.16 0.32 2.12e-9 Life satisfaction; CRC cis rs2795502 1.000 rs1581702 chr10:43344246 G/A cg27426351 chr10:43362370 NA 0.6 7.11 0.36 7.3e-12 Blood protein levels; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg14705778 chr4:174254825 HMGB2 0.44 6.59 0.34 1.72e-10 Intelligence (multi-trait analysis); CRC cis rs4665809 0.878 rs6748745 chr2:26364190 C/T cg25036284 chr2:26402008 FAM59B -0.48 -5.76 -0.3 1.96e-8 Gut microbiome composition (summer); CRC cis rs2762353 0.574 rs34067542 chr6:25728210 T/A cg07061783 chr6:25882402 NA 0.48 6.21 0.32 1.61e-9 Blood metabolite levels; CRC cis rs9322193 0.962 rs62441335 chr6:150113794 G/A cg13206674 chr6:150067644 NUP43 0.57 8.14 0.41 8.29e-15 Lung cancer; CRC cis rs8031584 0.918 rs61997140 chr15:31277312 A/G cg14829155 chr15:31115871 NA -0.5 -8.1 -0.41 1.09e-14 Huntington's disease progression; CRC cis rs6662572 0.737 rs4660901 chr1:46445257 G/A cg08644498 chr1:46502608 NA -0.46 -7.3 -0.37 2.16e-12 Blood protein levels; CRC trans rs1814175 0.586 rs2866862 chr11:49954588 T/C cg03929089 chr4:120376271 NA -0.91 -15.94 -0.66 8.84e-43 Height; CRC cis rs2885135 1.000 rs2885135 chr1:13906527 C/G cg04886857 chr1:13914270 PDPN 0.37 6.6 0.34 1.68e-10 Response to cytadine analogues (cytosine arabinoside); CRC cis rs780096 0.546 rs1104 chr2:27599875 T/G cg22903471 chr2:27725779 GCKR -0.37 -6.08 -0.32 3.27e-9 Total body bone mineral density; CRC cis rs9811920 0.638 rs793503 chr3:99588070 A/G cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G 0.45 5.98 0.31 5.85e-9 Axial length; CRC cis rs7927771 1.000 rs7947730 chr11:47786184 C/T cg18512352 chr11:47633146 NA -0.49 -9.48 -0.46 5.08e-19 Subjective well-being; CRC cis rs561341 1.000 rs55978022 chr17:30275937 T/C cg00745463 chr17:30367425 LRRC37B -0.89 -9.78 -0.47 5.21e-20 Hip circumference adjusted for BMI; CRC trans rs1728785 1.000 rs1615609 chr16:68596401 C/A cg04657470 chr2:198365150 HSPE1;HSPD1 0.59 7.14 0.37 5.95e-12 Ulcerative colitis; CRC cis rs78456975 1.000 rs55761535 chr2:1561450 A/G cg01028140 chr2:1542097 TPO -0.59 -6.17 -0.32 2.01e-9 Placebo response in major depressive disorder (% change in symptom score); CRC cis rs968567 1.000 rs968567 chr11:61595564 C/T cg16576620 chr11:61596068 FADS2 -0.45 -5.74 -0.3 2.2e-8 Blood metabolite levels;Rheumatoid arthritis;Vitiligo;Glycerophospholipid levels; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg09174674 chr1:9884042 CLSTN1 -0.41 -6.21 -0.32 1.64e-9 Myopia (pathological); CRC cis rs17345786 0.861 rs11707689 chr3:101086475 A/G cg11279151 chr3:101281821 RG9MTD1 -0.67 -8.38 -0.42 1.59e-15 Colonoscopy-negative controls vs population controls; CRC cis rs977987 0.800 rs1011121 chr16:75325933 A/G cg03315344 chr16:75512273 CHST6 0.54 9.01 0.44 1.71e-17 Dupuytren's disease; CRC trans rs10506458 0.915 rs12426308 chr12:63405778 C/T cg03429785 chr15:59498649 MYO1E;LDHAL6B -1.38 -20.5 -0.75 9.14e-61 Hemostatic factors and hematological phenotypes; CRC cis rs6942756 0.876 rs822038 chr7:129065477 A/G cg02491457 chr7:128862824 NA -0.59 -7.96 -0.4 2.89e-14 White matter hyperintensity burden; CRC cis rs2228479 0.850 rs62054610 chr16:89816920 G/A cg19635926 chr16:89946313 TCF25 0.66 5.97 0.31 6.1e-9 Skin colour saturation; CRC cis rs2806561 0.734 rs667211 chr1:23516142 T/C cg12483005 chr1:23474871 LUZP1 0.49 7.15 0.37 5.58e-12 Height; CRC trans rs11250098 0.541 rs6997997 chr8:10766082 T/C cg06636001 chr8:8085503 FLJ10661 -0.52 -7.65 -0.39 2.22e-13 Morning vs. evening chronotype; CRC cis rs9372498 0.536 rs28605789 chr6:118889952 G/A cg22561889 chr6:118971681 C6orf204 0.5 6.39 0.33 5.81e-10 Diastolic blood pressure; CRC cis rs1559088 0.576 rs4805852 chr19:33609441 C/T cg17764715 chr19:33622953 WDR88 0.46 6.8 0.35 4.87e-11 Bone ultrasound measurement (broadband ultrasound attenuation); CRC trans rs11343 0.675 rs7359333 chr16:19262344 A/T cg16239906 chr20:35724590 RBL1 -0.47 -6.19 -0.32 1.74e-9 Parkinson's disease; CRC cis rs10504229 1.000 rs72650885 chr8:58175131 G/A cg02725872 chr8:58115012 NA -0.38 -6.43 -0.33 4.44e-10 Developmental language disorder (linguistic errors); CRC cis rs736408 0.609 rs13095332 chr3:52787242 C/T cg10802521 chr3:52805072 NEK4 -0.57 -8.73 -0.43 1.32e-16 Bipolar disorder; CRC cis rs11009175 0.725 rs10827170 chr10:33290343 C/G cg00146027 chr10:33299147 NA 0.31 6.11 0.32 2.86e-9 Depression (quantitative trait); CRC cis rs780096 0.506 rs8395 chr2:27715207 T/A cg17158414 chr2:27665306 KRTCAP3 -0.28 -6.09 -0.32 3.11e-9 Total body bone mineral density; CRC cis rs34779708 0.931 rs12773169 chr10:35366462 G/C cg03585969 chr10:35415529 CREM 0.59 7.85 0.4 6.04e-14 Inflammatory bowel disease;Crohn's disease; CRC cis rs8177179 0.967 rs9820225 chr3:133449189 A/G cg17775713 chr3:133465469 TF 0.37 6.76 0.35 6.35e-11 Iron status biomarkers (transferrin levels); CRC cis rs6662572 0.737 rs11211214 chr1:46347328 C/T cg08644498 chr1:46502608 NA -0.46 -7.3 -0.37 2.2e-12 Blood protein levels; CRC cis rs4713118 0.621 rs9295756 chr6:28033396 G/T cg25164649 chr6:28176230 NA 0.7 8.96 0.44 2.42e-17 Parkinson's disease; CRC cis rs7044106 0.690 rs10739569 chr9:123361027 C/G cg09419670 chr9:123605666 PSMD5;LOC253039 0.54 8.24 0.41 4.15e-15 Hip circumference adjusted for BMI; CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg01279709 chr13:28196083 POLR1D;LNX2 -0.53 -6.35 -0.33 7.21e-10 Diisocyanate-induced asthma; CRC cis rs13064411 0.542 rs2087130 chr3:113226983 T/A cg18753928 chr3:113234510 CCDC52 -0.53 -8.13 -0.41 8.8e-15 Response to simvastatin treatment (PCSK9 protein level change); CRC cis rs7647973 0.516 rs4499638 chr3:49202782 C/G cg07636037 chr3:49044803 WDR6 0.84 12.77 0.58 1.27e-30 Menarche (age at onset); CRC cis rs17767392 0.705 rs4899393 chr14:71739924 C/T cg13720639 chr14:72061746 SIPA1L1 -0.47 -5.96 -0.31 6.47e-9 Mitral valve prolapse; CRC cis rs763014 0.932 rs34498660 chr16:666149 A/G cg09263875 chr16:632152 PIGQ 0.78 12.71 0.57 2.25e-30 Height; CRC cis rs875971 0.964 rs6978721 chr7:65883204 A/G cg00343986 chr7:65444356 GUSB 0.43 6.3 0.33 9.66e-10 Aortic root size; CRC cis rs908922 0.584 rs10888500 chr1:152532749 G/A cg09873164 chr1:152488093 CRCT1 0.36 6.16 0.32 2.11e-9 Hair morphology; CRC cis rs7119 0.651 rs12904200 chr15:77845902 C/G cg10437265 chr15:77819839 NA 0.59 9.99 0.48 1.03e-20 Type 2 diabetes; CRC cis rs1218582 0.772 rs4845693 chr1:154911257 A/G cg16680214 chr1:154839983 KCNN3 0.45 8.52 0.43 5.96e-16 Prostate cancer; CRC cis rs2380220 0.541 rs72928277 chr6:96079745 G/T cg04719120 chr6:96025338 MANEA -0.74 -9.08 -0.45 1.03e-17 Behavioural disinhibition (generation interaction); CRC cis rs9549367 0.789 rs3764125 chr13:113897648 A/G cg18105134 chr13:113819100 PROZ 0.69 9.42 0.46 8.49e-19 Platelet distribution width; CRC cis rs1005277 0.579 rs2983343 chr10:38383332 A/G cg25427524 chr10:38739819 LOC399744 -0.77 -13.64 -0.6 6.68e-34 Extrinsic epigenetic age acceleration; CRC cis rs2153535 0.553 rs2984099 chr6:8637274 C/T cg07606381 chr6:8435919 SLC35B3 -0.8 -10.61 -0.51 7.95e-23 Motion sickness; CRC cis rs1150668 0.768 rs1233713 chr6:28198281 A/G cg12273811 chr6:28175739 NA 0.45 7.01 0.36 1.39e-11 Pubertal anthropometrics; CRC cis rs9648716 1.000 rs10255711 chr7:140608476 C/A cg10747023 chr7:140774559 NA 0.47 6.02 0.32 4.63e-9 Type 2 diabetes; CRC cis rs1009181 0.585 rs2066295 chr6:26168903 A/G cg13736514 chr6:26305472 NA -0.4 -5.9 -0.31 8.91e-9 Childhood ear infection; CRC cis rs473651 0.904 rs10929275 chr2:239323169 A/G cg08773314 chr2:239334832 ASB1 0.37 8.56 0.43 4.47e-16 Multiple system atrophy; CRC cis rs9916302 0.706 rs667193 chr17:37448835 T/C cg00129232 chr17:37814104 STARD3 0.59 7.37 0.38 1.37e-12 Glomerular filtration rate (creatinine); CRC cis rs11252926 1.000 rs11252926 chr10:566379 C/T cg18196295 chr10:418757 DIP2C -0.56 -7.77 -0.39 9.81e-14 Psychosis in Alzheimer's disease; CRC cis rs6951245 0.638 rs4720486 chr7:1146764 G/A cg03188948 chr7:1209495 NA 0.54 6.34 0.33 7.39e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs3806843 1.000 rs2098058 chr5:140157427 A/C cg19875535 chr5:140030758 IK -0.6 -9.86 -0.48 2.84e-20 Depressive symptoms (multi-trait analysis); CRC cis rs5758511 0.773 rs10154700 chr22:42365073 G/T cg00645731 chr22:42541494 CYP2D7P1 0.54 8.24 0.41 4.26e-15 Birth weight; CRC cis rs4423214 1.000 rs2276362 chr11:71174452 A/G cg05163923 chr11:71159392 DHCR7 0.65 9.35 0.46 1.43e-18 Vitamin D levels; CRC cis rs1401999 0.714 rs7646621 chr3:183640865 A/C cg05044414 chr3:183734942 ABCC5 -0.34 -5.62 -0.3 4.04e-8 Anterior chamber depth; CRC cis rs769267 0.740 rs2965185 chr19:19525792 T/C cg03709012 chr19:19516395 GATAD2A 0.52 7.33 0.37 1.78e-12 Tonsillectomy; CRC cis rs6724607 1.000 rs6724607 chr2:191466532 C/T cg27211696 chr2:191398769 TMEM194B 0.43 6.36 0.33 6.91e-10 Pulse pressure; CRC cis rs7618915 0.547 rs11177 chr3:52721305 G/A cg18099408 chr3:52552593 STAB1 -0.44 -7.19 -0.37 4.28e-12 Bipolar disorder; CRC cis rs2991971 0.810 rs2036021 chr1:45901370 G/A cg15605315 chr1:45957053 TESK2 0.38 6.08 0.32 3.26e-9 High light scatter reticulocyte count; CRC cis rs1182196 0.502 rs757786 chr7:2836019 C/T cg09658497 chr7:2847517 GNA12 -0.37 -6.13 -0.32 2.51e-9 Plateletcrit; CRC cis rs9341808 0.718 rs3805922 chr6:80891989 A/G cg08355045 chr6:80787529 NA 0.43 6.95 0.36 1.94e-11 Sitting height ratio; CRC cis rs7618915 0.501 rs13079063 chr3:52744460 A/G cg08222913 chr3:52553049 STAB1 -0.33 -6.13 -0.32 2.5e-9 Bipolar disorder; CRC cis rs4523957 0.788 rs2169357 chr17:2096441 C/T cg16513277 chr17:2031491 SMG6 -0.56 -9.45 -0.46 6.8e-19 Autism spectrum disorder or schizophrenia;Schizophrenia; CRC cis rs10504229 0.596 rs7004566 chr8:58115602 G/C cg21724239 chr8:58056113 NA 0.49 6.81 0.35 4.75e-11 Developmental language disorder (linguistic errors); CRC cis rs12900413 0.879 rs2165072 chr15:90302629 A/G cg24249390 chr15:90295951 MESP1 -0.63 -9.01 -0.44 1.72e-17 Coronary artery aneurysm in Kawasaki disease; CRC cis rs1784581 0.651 rs1784590 chr6:162389462 C/A cg17173639 chr6:162384350 PARK2 -0.71 -11.88 -0.55 2.46e-27 Itch intensity from mosquito bite; CRC cis rs13191362 1.000 rs13202339 chr6:163081812 G/A cg14584255 chr6:163149320 PACRG;PARK2 0.43 6.14 0.32 2.38e-9 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs7666738 0.791 rs1896155 chr4:99020948 C/A cg17366294 chr4:99064904 C4orf37 0.43 7.29 0.37 2.28e-12 Colonoscopy-negative controls vs population controls; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg04204557 chr21:46065774 KRTAP10-11;C21orf29 -0.4 -6.49 -0.34 3.18e-10 Liver disease severity in Alagille syndrome; CRC cis rs769267 0.825 rs1469713 chr19:19528806 A/G cg02546618 chr19:19431379 KIAA0892;SF4 0.45 6.26 0.33 1.18e-9 Tonsillectomy; CRC cis rs7666738 0.830 rs11727612 chr4:99001662 T/C cg05340658 chr4:99064831 C4orf37 0.61 9.54 0.47 3.44e-19 Colonoscopy-negative controls vs population controls; CRC cis rs2019137 0.936 rs3828188 chr2:113954247 G/A cg07772999 chr2:113993052 PAX8;LOC440839;LOC654433 -0.45 -6.34 -0.33 7.77e-10 Lymphocyte counts; CRC cis rs6831352 0.918 rs7694646 chr4:100059732 T/A cg12011299 chr4:100065546 ADH4 -0.5 -9.49 -0.46 5.01e-19 Alcohol dependence; CRC cis rs6912958 0.712 rs4706294 chr6:88317675 G/C cg12350822 chr6:88032061 C6orf162;GJB7 -0.32 -6.02 -0.31 4.67e-9 Monocyte percentage of white cells; CRC cis rs1865760 0.573 rs7450342 chr6:25919480 T/C cg12310025 chr6:25882481 NA -0.44 -6.57 -0.34 1.95e-10 Height; CRC cis rs73206853 0.764 rs73191817 chr12:110918673 G/A cg12870014 chr12:110450643 ANKRD13A 0.84 9.69 0.47 1.07e-19 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC cis rs7523050 0.643 rs36052234 chr1:109402943 C/T cg08274380 chr1:109419600 GPSM2 0.85 6.65 0.34 1.24e-10 Fat distribution (HIV); CRC cis rs9611565 0.503 rs5996062 chr22:42167464 C/G cg06634786 chr22:41940651 POLR3H 0.66 7.3 0.37 2.18e-12 Vitiligo; CRC cis rs28386778 0.897 rs2584642 chr17:61942427 T/C cg25654072 chr17:61904446 PSMC5;FTSJ3 0.69 10.69 0.51 4.27e-23 Prudent dietary pattern; CRC cis rs6088580 0.634 rs6142157 chr20:32984172 C/G cg24642439 chr20:33292090 TP53INP2 -0.38 -6.41 -0.33 5.03e-10 Glomerular filtration rate (creatinine); CRC cis rs9682041 0.808 rs9875109 chr3:170064776 A/G cg11886554 chr3:170076028 SKIL -0.62 -7.2 -0.37 4.06e-12 Glomerular filtration rate in non diabetics (creatinine);Glomerular filtration rate (creatinine); CRC cis rs3096299 0.781 rs2965819 chr16:89501030 G/T cg00750074 chr16:89608354 SPG7 0.39 5.76 0.3 1.9e-8 Multiple myeloma (IgH translocation); CRC trans rs17661538 0.685 rs2497810 chr10:18360504 C/G cg13235825 chr11:107574836 NA 0.49 6.01 0.31 4.99e-9 Response to antipsychotic treatment; CRC cis rs10464366 0.544 rs2280667 chr7:39172228 A/C cg18850127 chr7:39170497 POU6F2 0.54 7.17 0.37 4.97e-12 IgG glycosylation; CRC cis rs7119 0.651 rs12902948 chr15:77849254 T/C cg27398640 chr15:77910606 LINGO1 -0.43 -7.17 -0.37 5.13e-12 Type 2 diabetes; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg25261059 chr19:44031185 ETHE1 0.41 6.47 0.34 3.63e-10 Liver disease severity in Alagille syndrome; CRC cis rs11122272 0.735 rs910824 chr1:231498773 C/G cg06096015 chr1:231504339 EGLN1 0.39 5.93 0.31 7.87e-9 Hemoglobin concentration; CRC cis rs6963495 0.818 rs56165465 chr7:105180384 C/T cg13798780 chr7:105162888 PUS7 0.56 7.36 0.38 1.45e-12 Bipolar disorder (body mass index interaction); CRC cis rs2645694 0.626 rs2703119 chr4:77823640 C/T cg03477792 chr4:77819574 ANKRD56 0.46 6.75 0.35 6.79e-11 Emphysema distribution in smoking; CRC cis rs1506636 1.000 rs615410 chr7:123437765 T/C cg03229431 chr7:123269106 ASB15 0.69 10.7 0.51 4.14e-23 Plateletcrit;Platelet count; CRC cis rs13161895 1.000 rs4700853 chr5:179473328 G/A cg02702477 chr5:179499311 RNF130 0.55 6.26 0.33 1.18e-9 LDL cholesterol; CRC cis rs1865760 0.964 rs1324084 chr6:25915134 C/T cg17691542 chr6:26056736 HIST1H1C 0.57 8.59 0.43 3.66e-16 Height; CRC cis rs140365914 1 rs140365914 chr7:155106570 C/T cg04811098 chr7:155088454 INSIG1 0.42 6.49 0.34 3.17e-10 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs4664293 0.647 rs12623149 chr2:160447346 A/G cg08347373 chr2:160653686 CD302 -0.38 -6.48 -0.34 3.42e-10 Monocyte percentage of white cells; CRC cis rs1348850 0.574 rs13431105 chr2:178434674 A/G cg27490568 chr2:178487706 NA 0.71 7.98 0.4 2.51e-14 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs2180341 0.513 rs12196828 chr6:127696864 C/T cg27446573 chr6:127587934 RNF146 0.62 9.09 0.45 9.37e-18 Breast cancer; CRC cis rs1552244 1.000 rs76041173 chr3:10078695 G/T cg13047869 chr3:10149882 C3orf24 0.57 7.74 0.39 1.26e-13 Alzheimer's disease; CRC cis rs4423214 0.879 rs1792283 chr11:71135136 T/C cg13043300 chr11:71146211 DHCR7 -0.42 -5.82 -0.31 1.37e-8 Vitamin D levels; CRC cis rs9462027 0.628 rs6921363 chr6:34770820 A/G cg07306190 chr6:34760872 UHRF1BP1 -0.33 -5.92 -0.31 8.21e-9 Systemic lupus erythematosus; CRC cis rs79349575 0.783 rs4794000 chr17:47022755 C/G cg22482690 chr17:47019901 SNF8 0.48 8.01 0.4 2.01e-14 Type 2 diabetes; CRC cis rs4595586 0.546 rs11169801 chr12:39241429 G/A cg26384229 chr12:38710491 ALG10B 0.54 6.65 0.34 1.23e-10 Morning vs. evening chronotype; CRC cis rs11190604 1.000 rs3750630 chr10:102275780 A/G cg07080220 chr10:102295463 HIF1AN 0.46 5.79 0.3 1.65e-8 Palmitoleic acid (16:1n-7) levels; CRC cis rs68170813 0.641 rs74524528 chr7:107090979 G/A cg02696742 chr7:106810147 HBP1 -0.57 -5.91 -0.31 8.42e-9 Coronary artery disease; CRC cis rs7811142 0.830 rs77861211 chr7:99962096 T/C cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.73 9.99 0.48 1.07e-20 Platelet count; CRC trans rs925098 0.577 rs2724470 chr4:17996046 A/G cg26801646 chr10:76970496 VDAC2 -0.45 -6.9 -0.36 2.76e-11 Birth weight;Height; CRC cis rs1552244 0.882 rs9757159 chr3:10039166 C/T cg00166722 chr3:10149974 C3orf24 0.61 8.0 0.4 2.17e-14 Alzheimer's disease; CRC cis rs9399135 0.967 rs9389251 chr6:135325717 A/G cg24558204 chr6:135376177 HBS1L 0.51 8.13 0.41 9e-15 Red blood cell count; CRC cis rs4713118 0.955 rs9380010 chr6:27683572 A/G cg19041857 chr6:27730383 NA -0.42 -5.94 -0.31 7.29e-9 Parkinson's disease; CRC cis rs4555082 0.874 rs1882846 chr14:105717448 G/C cg13114125 chr14:105738426 BRF1 -0.79 -11.64 -0.54 1.92e-26 Mean platelet volume;Platelet distribution width; CRC cis rs61774743 0.521 rs60144015 chr1:41845246 C/A cg00290994 chr1:41848739 NA 0.56 8.64 0.43 2.44e-16 Intelligence (multi-trait analysis); CRC cis rs3796619 0.924 rs11940546 chr4:1072485 C/T cg27284194 chr4:1044797 NA 0.42 6.43 0.33 4.43e-10 Recombination rate (males); CRC cis rs6502050 0.734 rs7217625 chr17:80157766 T/C cg19223190 chr17:80058835 NA 0.41 6.7 0.35 8.79e-11 Life satisfaction; CRC cis rs2495707 0.624 rs2489007 chr10:102422046 A/G cg24024056 chr10:102415556 NA 0.36 7.19 0.37 4.34e-12 Body mass index; CRC cis rs1552244 1.000 rs6786638 chr3:10118075 G/C cg02579736 chr3:10068473 FANCD2;CIDECP 1.02 13.77 0.6 2.25e-34 Alzheimer's disease; CRC cis rs45509595 0.841 rs370155 chr6:27782031 T/G cg08798685 chr6:27730294 NA -0.63 -6.14 -0.32 2.38e-9 Breast cancer; CRC cis rs1799949 0.965 rs8176310 chr17:41199913 T/C cg19454999 chr17:41278357 BRCA1;NBR2 0.4 6.13 0.32 2.47e-9 Menopause (age at onset); CRC cis rs7713065 0.531 rs2522051 chr5:131797578 C/T cg22638593 chr5:131593259 PDLIM4 0.33 5.93 0.31 7.5e-9 Lung function (FEV1/FVC); CRC cis rs6461049 0.765 rs10224497 chr7:2149967 A/G cg21782813 chr7:2030301 MAD1L1 0.42 7.72 0.39 1.38e-13 Schizophrenia; CRC cis rs2576037 0.526 rs2051292 chr18:44484372 C/G cg23996704 chr18:44553084 KATNAL2 -0.3 -5.83 -0.31 1.34e-8 Personality dimensions; CRC cis rs4908760 0.868 rs12131864 chr1:8591162 A/G cg20416874 chr1:8611966 RERE -0.46 -6.66 -0.34 1.16e-10 Vitiligo; CRC cis rs78707713 0.535 rs3812705 chr10:71211146 A/G cg12610070 chr10:71211762 TSPAN15 -0.42 -7.66 -0.39 2.04e-13 Venous thromboembolism; CRC cis rs35883536 0.967 rs3904673 chr1:101137162 A/C cg14515779 chr1:101123966 NA -0.41 -7.97 -0.4 2.69e-14 Monocyte count; CRC cis rs34172651 0.517 rs2287783 chr16:24831727 C/T cg02428538 chr16:24856791 SLC5A11 -0.54 -6.33 -0.33 7.82e-10 Intelligence (multi-trait analysis); CRC cis rs12618769 0.625 rs3769709 chr2:99187433 A/T cg18455616 chr2:99124870 INPP4A 0.36 5.87 0.31 1.07e-8 Bipolar disorder; CRC cis rs4964805 1.000 rs73192053 chr12:104190855 A/G cg02344784 chr12:104178138 NT5DC3 0.56 8.45 0.42 9.23e-16 Attention deficit hyperactivity disorder; CRC cis rs1448094 0.511 rs61930581 chr12:86157241 G/A cg18827107 chr12:86230957 RASSF9 -0.41 -6.18 -0.32 1.89e-9 Major depressive disorder; CRC cis rs6502050 0.842 rs62079996 chr17:80076862 A/G cg22110888 chr17:80059540 CCDC57 -0.42 -6.62 -0.34 1.48e-10 Life satisfaction; CRC cis rs2842992 0.789 rs3818300 chr6:160201677 G/A cg11366901 chr6:160182831 ACAT2 0.97 14.27 0.62 2.74e-36 Age-related macular degeneration (geographic atrophy); CRC cis rs6502050 0.835 rs6502067 chr17:80111205 A/G cg25804541 chr17:80189381 SLC16A3 -0.31 -5.97 -0.31 6.08e-9 Life satisfaction; CRC trans rs208520 0.690 rs1563929 chr6:66702108 G/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 1.04 14.68 0.63 7.01e-38 Exhaled nitric oxide output; CRC cis rs28386778 0.897 rs894406 chr17:61901657 A/G cg22520471 chr17:61851767 DDX42;CCDC47 0.75 11.75 0.54 7.35e-27 Prudent dietary pattern; CRC cis rs9891119 0.524 rs3736164 chr17:40539825 T/G cg06270615 chr17:40516068 STAT3 0.31 6.48 0.34 3.39e-10 Multiple sclerosis;Crohn's disease; CRC cis rs4319547 0.695 rs10846699 chr12:122853073 A/G cg05707623 chr12:122985044 ZCCHC8 0.73 9.43 0.46 7.79e-19 Body mass index; CRC cis rs9399137 0.507 rs13209780 chr6:135344795 G/C cg22676075 chr6:135203613 NA 0.59 8.87 0.44 4.6e-17 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; CRC cis rs6502050 0.787 rs7222326 chr17:80057272 T/C cg19223190 chr17:80058835 NA -0.49 -7.85 -0.4 5.86e-14 Life satisfaction; CRC cis rs1862618 0.853 rs3099459 chr5:56137170 G/C cg22800045 chr5:56110881 MAP3K1 0.58 6.33 0.33 8.25e-10 Initial pursuit acceleration; CRC cis rs13191362 1.000 rs35911566 chr6:162994154 T/C cg06582575 chr6:163149167 PACRG;PARK2 0.8 10.98 0.52 4.33e-24 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs796364 0.806 rs76568708 chr2:200929531 C/T cg25936922 chr2:200820526 C2orf60;C2orf47 -0.68 -6.47 -0.34 3.59e-10 Schizophrenia; CRC cis rs2836950 0.565 rs2836942 chr21:40591381 A/G cg17971929 chr21:40555470 PSMG1 -0.59 -8.67 -0.43 2.01e-16 Menarche (age at onset); CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg20848987 chr17:41116355 AARSD1 0.47 6.0 0.31 5.3e-9 Thyroid stimulating hormone; CRC cis rs826838 0.933 rs1906263 chr12:38653362 T/C cg26384229 chr12:38710491 ALG10B 0.71 10.11 0.49 4.37e-21 Heart rate; CRC cis rs10883723 0.810 rs10748824 chr10:104274466 T/C cg04362960 chr10:104952993 NT5C2 -0.42 -5.94 -0.31 7.28e-9 Allergic disease (asthma, hay fever or eczema); CRC cis rs7091068 0.518 rs4144098 chr10:95432600 C/T cg20715218 chr10:95462985 C10orf4 0.54 7.4 0.38 1.14e-12 Urinary tract infection frequency; CRC cis rs11098499 0.865 rs1112817 chr4:120297800 T/C cg24375607 chr4:120327624 NA 0.51 7.86 0.4 5.5e-14 Corneal astigmatism; CRC cis rs6502050 0.769 rs9916231 chr17:80119645 A/G cg25804541 chr17:80189381 SLC16A3 -0.31 -6.02 -0.32 4.6e-9 Life satisfaction; CRC cis rs67478160 0.643 rs11624184 chr14:104240998 A/G cg08213375 chr14:104286397 PPP1R13B 0.67 13.57 0.6 1.32e-33 Schizophrenia; CRC cis rs9868809 0.772 rs2302295 chr3:48690110 T/C cg07636037 chr3:49044803 WDR6 -0.69 -6.99 -0.36 1.5e-11 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg21509819 chr19:6737662 GPR108 0.42 6.43 0.33 4.55e-10 Liver disease severity in Alagille syndrome; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg05610740 chr12:96794311 CDK17 0.44 7.76 0.39 1.08e-13 Liver disease severity in Alagille syndrome; CRC cis rs208515 0.560 rs207084 chr6:66776966 T/C cg07460842 chr6:66804631 NA -1.12 -21.12 -0.76 3.49e-63 Exhaled nitric oxide levels; CRC cis rs896854 0.654 rs896846 chr8:95972453 G/A cg09323728 chr8:95962352 TP53INP1 -0.45 -7.46 -0.38 7.88e-13 Type 2 diabetes; CRC cis rs3540 0.597 rs7498113 chr15:91051192 C/G cg22089800 chr15:90895588 ZNF774 -0.57 -9.41 -0.46 9.04e-19 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; CRC cis rs78456975 1.000 rs11883965 chr2:1560062 T/C cg12573674 chr2:1569213 NA -0.77 -8.09 -0.41 1.13e-14 Placebo response in major depressive disorder (% change in symptom score); CRC cis rs10751667 1.000 rs6597965 chr11:964476 A/G ch.11.42038R chr11:967971 AP2A2 0.68 11.3 0.53 3.18e-25 Alzheimer's disease (late onset); CRC cis rs7412746 0.658 rs7528773 chr1:150915875 G/A cg18016565 chr1:150552671 MCL1 0.42 6.06 0.32 3.8e-9 Melanoma; CRC cis rs3008870 0.583 rs17497947 chr1:67457199 G/T cg08660285 chr1:67390436 MIER1;WDR78 -1.02 -12.41 -0.56 2.97e-29 Lymphocyte percentage of white cells; CRC cis rs10504229 0.683 rs56058640 chr8:58128862 C/T cg05313129 chr8:58192883 C8orf71 -0.43 -6.11 -0.32 2.74e-9 Developmental language disorder (linguistic errors); CRC cis rs738322 0.553 rs28565947 chr22:38570775 C/G cg25457927 chr22:38595422 NA -0.31 -5.86 -0.31 1.13e-8 Cutaneous nevi; CRC cis rs9914988 1.000 rs6803 chr17:27187789 C/T cg12682573 chr17:27188876 MIR451;MIR144 -0.6 -8.99 -0.44 1.93e-17 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs9372498 0.536 rs9489467 chr6:118935206 C/T cg18833306 chr6:118973337 C6orf204 0.45 5.81 0.3 1.49e-8 Diastolic blood pressure; CRC cis rs8072100 1.000 rs7210738 chr17:45757598 G/A cg25173405 chr17:45401733 C17orf57 0.47 7.3 0.37 2.19e-12 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs11864453 0.826 rs2074627 chr16:72136769 C/T cg23815491 chr16:72088622 HP 0.53 8.11 0.41 1.04e-14 Fibrinogen levels; CRC cis rs7945705 0.791 rs12421789 chr11:8813956 G/A cg21881798 chr11:8931708 C11orf17;ST5 -0.57 -9.25 -0.45 3.01e-18 Hemoglobin concentration; CRC cis rs7107174 1.000 rs4627115 chr11:78007873 T/G cg02023728 chr11:77925099 USP35 0.52 7.45 0.38 8.29e-13 Testicular germ cell tumor; CRC cis rs1499614 1.000 rs1882655 chr7:66147057 T/C cg25985355 chr7:65971099 NA 0.52 5.95 0.31 6.88e-9 Gout; CRC cis rs2730245 0.527 rs62476464 chr7:158698063 C/T cg24397884 chr7:158709396 WDR60 0.95 11.76 0.54 6.68e-27 Height; CRC cis rs2235649 0.746 rs35104579 chr16:1848657 A/T cg00935504 chr16:1863053 HAGH 0.31 5.65 0.3 3.39e-8 Blood metabolite levels; CRC trans rs17056278 1.000 rs10077799 chr5:158272083 C/T cg07204479 chr12:89915527 WDR51B;GALNT4 -0.48 -6.05 -0.32 3.92e-9 Hip circumference (psychosocial stress interaction); CRC cis rs2120019 0.938 rs35911108 chr15:75322179 G/A cg11632617 chr15:75315747 PPCDC -0.57 -7.79 -0.39 8.82e-14 Blood trace element (Zn levels); CRC cis rs10128264 0.902 rs942797 chr10:80986432 C/T cg18737081 chr10:80999807 ZMIZ1 -0.37 -6.41 -0.33 4.95e-10 Response to methotrexate in juvenile idiopathic arthritis; CRC cis rs7666738 0.830 rs1426665 chr4:99027764 C/T cg17366294 chr4:99064904 C4orf37 0.43 7.13 0.37 6.27e-12 Colonoscopy-negative controls vs population controls; CRC cis rs9611565 0.840 rs3788584 chr22:41779073 T/A cg03806693 chr22:41940476 POLR3H -1.08 -13.76 -0.6 2.34e-34 Vitiligo; CRC cis rs13191362 1.000 rs13190742 chr6:163008758 G/A cg21926612 chr6:163149169 PACRG;PARK2 0.78 10.8 0.51 1.77e-23 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs875971 0.862 rs7803416 chr7:65954199 A/G cg11764359 chr7:65958608 NA 0.63 10.13 0.49 3.71e-21 Aortic root size; CRC cis rs427941 0.632 rs201503 chr7:101759595 C/G cg06246474 chr7:101738831 CUX1 0.44 6.86 0.35 3.35e-11 Plasma omega-3 polyunsaturated fatty acid level (eicosapentaenoic acid); CRC cis rs995000 0.931 rs656297 chr1:62907595 A/G cg19896129 chr1:63156450 NA 0.44 6.77 0.35 5.88e-11 Triglyceride levels; CRC cis rs4803468 0.763 rs17318596 chr19:41937095 A/G cg09537434 chr19:41945824 ATP5SL -0.95 -17.34 -0.69 2.62e-48 Height; CRC cis rs2070488 0.745 rs7649153 chr3:38467753 T/A cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.56 8.19 0.41 5.82e-15 Electrocardiographic conduction measures; CRC cis rs8130944 0.828 rs4920134 chr21:44111151 T/C cg23590273 chr21:44105265 PDE9A -0.35 -5.62 -0.3 3.99e-8 Perceived unattractiveness to mosquitoes; CRC cis rs10504229 0.683 rs6995355 chr8:58113870 C/T cg02290350 chr8:58132656 NA -0.58 -8.24 -0.41 4.09e-15 Developmental language disorder (linguistic errors); CRC cis rs2274273 0.529 rs10131562 chr14:55847015 G/A cg10130446 chr14:55658398 DLGAP5 -0.41 -5.82 -0.31 1.38e-8 Protein biomarker; CRC cis rs972578 0.836 rs738539 chr22:43282801 A/C cg01576275 chr22:43409880 NA -0.41 -6.44 -0.33 4.16e-10 Mean platelet volume; CRC cis rs9491140 0.539 rs11154226 chr6:124681785 G/A cg22366943 chr6:124882293 NKAIN2 0.53 7.56 0.38 4.16e-13 Neuroticism; CRC cis rs7246865 0.871 rs10421727 chr19:17225128 G/A cg19418318 chr19:17219073 MYO9B 0.51 8.64 0.43 2.51e-16 Reticulocyte fraction of red cells; CRC cis rs11608355 0.521 rs6606706 chr12:109830173 C/T cg19025524 chr12:109796872 NA -0.56 -9.01 -0.44 1.74e-17 Neuroticism; CRC cis rs6701037 0.566 rs10489326 chr1:175134677 A/G cg17845761 chr1:175162550 KIAA0040 0.3 6.44 0.33 4.23e-10 Alcohol dependence; CRC trans rs1005277 0.579 rs2474571 chr10:38384639 T/G cg23533926 chr12:111358616 MYL2 -0.52 -7.83 -0.4 6.77e-14 Extrinsic epigenetic age acceleration; CRC cis rs2625529 0.730 rs1481861 chr15:72240129 A/G cg16672083 chr15:72433130 SENP8 0.45 6.45 0.34 3.89e-10 Red blood cell count; CRC cis rs7487075 1.000 rs7976280 chr12:46800825 G/A cg17501823 chr12:47219793 SLC38A4 0.32 5.64 0.3 3.58e-8 Itch intensity from mosquito bite; CRC cis rs881375 0.933 rs4837804 chr9:123705304 C/G cg14255062 chr9:123606675 PSMD5;LOC253039 0.4 5.79 0.3 1.64e-8 Rheumatoid arthritis; CRC cis rs6495122 0.501 rs8039755 chr15:75337426 T/C cg17294928 chr15:75287854 SCAMP5 -0.41 -6.04 -0.32 4.14e-9 Caffeine consumption;Diastolic blood pressure;Coffee consumption; CRC cis rs4665809 0.652 rs6727974 chr2:26524639 A/G cg25036284 chr2:26402008 FAM59B 0.45 6.14 0.32 2.33e-9 Gut microbiome composition (summer); CRC cis rs1451375 0.669 rs59086818 chr7:50653830 G/A cg18232548 chr7:50535776 DDC 0.44 6.3 0.33 9.55e-10 Malaria; CRC cis rs6815814 0.950 rs5743557 chr4:38806827 G/A cg06935464 chr4:38784597 TLR10 0.57 5.97 0.31 6.19e-9 Breast cancer; CRC cis rs10504229 0.636 rs77290284 chr8:58055269 G/T cg02290350 chr8:58132656 NA -0.6 -6.94 -0.36 2.16e-11 Developmental language disorder (linguistic errors); CRC cis rs9322817 1.000 rs9322817 chr6:105232233 A/C cg02098413 chr6:105308735 HACE1 -0.33 -6.0 -0.31 5.09e-9 Thyroid stimulating hormone; CRC cis rs9660992 0.710 rs1668869 chr1:205239779 G/C cg21643547 chr1:205240462 TMCC2 -0.46 -7.31 -0.37 2.04e-12 Mean corpuscular volume;Mean platelet volume; CRC cis rs9649213 0.593 rs3801254 chr7:98010811 G/A cg24562669 chr7:97807699 LMTK2 0.43 7.18 0.37 4.75e-12 Prostate cancer (SNP x SNP interaction); CRC cis rs73200209 0.912 rs10507267 chr12:116500910 T/C cg01776926 chr12:116560359 MED13L -0.53 -6.53 -0.34 2.53e-10 Total body bone mineral density; CRC cis rs501120 0.584 rs906944 chr10:44705439 G/A cg09554077 chr10:44749378 NA 0.65 7.61 0.39 2.94e-13 Coronary artery disease;Coronary heart disease; CRC cis rs6504622 0.967 rs9889762 chr17:45026366 C/T cg16759221 chr17:45003025 GOSR2 -0.49 -7.92 -0.4 3.72e-14 Orofacial clefts; CRC cis rs2227564 0.678 rs2242256 chr10:75597546 C/G cg16540259 chr10:75572220 NDST2 -0.47 -6.74 -0.35 6.97e-11 Crohn's disease;Inflammatory bowel disease; CRC cis rs4594175 0.926 rs4349056 chr14:51625819 A/G cg23942311 chr14:51606299 NA 0.65 10.85 0.51 1.21e-23 Cancer; CRC trans rs6951245 0.554 rs2070118 chr7:1132505 G/A cg13565492 chr6:43139072 SRF -0.83 -10.48 -0.5 2.33e-22 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs2249625 0.545 rs2463743 chr6:72874741 C/T cg18830697 chr6:72922368 RIMS1 -0.39 -7.83 -0.4 6.67e-14 Acute urticaria and angioedema (non-steroidal anti-inflammatory drug-induced); CRC cis rs7927771 0.832 rs55677087 chr11:47397714 C/G cg18512352 chr11:47633146 NA -0.37 -7.22 -0.37 3.58e-12 Subjective well-being; CRC cis rs736408 0.609 rs2230534 chr3:52802402 A/C cg11645453 chr3:52864694 ITIH4 0.35 6.11 0.32 2.8e-9 Bipolar disorder; CRC cis rs911186 0.786 rs3800307 chr6:27185792 A/T cg12292205 chr6:26970375 C6orf41 -0.73 -8.51 -0.42 6.28e-16 Autism spectrum disorder or schizophrenia; CRC cis rs3772130 0.583 rs28497949 chr3:121448675 T/A cg20356878 chr3:121714668 ILDR1 0.56 10.19 0.49 2.29e-21 Cognitive performance; CRC cis rs7618915 0.571 rs34115864 chr3:52612178 A/G cg15147215 chr3:52552868 STAB1 -0.63 -10.56 -0.5 1.22e-22 Bipolar disorder; CRC cis rs898097 0.756 rs11655103 chr17:80813467 T/C cg16060761 chr17:80687452 NA 0.4 5.95 0.31 6.88e-9 Breast cancer; CRC cis rs6570726 0.935 rs385134 chr6:145851005 C/T cg23711669 chr6:146136114 FBXO30 0.68 12.3 0.56 7.07e-29 Lobe attachment (rater-scored or self-reported); CRC cis rs7224737 1.000 rs9912088 chr17:40288278 T/C cg20291162 chr17:40259547 DHX58 -0.55 -8.1 -0.41 1.06e-14 Fibrinogen levels; CRC cis rs4319547 0.915 rs11058402 chr12:122981053 A/G cg23029597 chr12:123009494 RSRC2 -0.61 -7.61 -0.39 2.85e-13 Body mass index; CRC cis rs67311347 1.000 rs7612015 chr3:40399974 A/C cg09455208 chr3:40491958 NA 0.43 9.0 0.44 1.8e-17 Renal cell carcinoma; CRC cis rs6062509 0.965 rs6062504 chr20:62348907 A/G cg21849932 chr20:62369462 LIME1 -0.4 -5.64 -0.3 3.62e-8 Prostate cancer; CRC cis rs262150 0.574 rs2730273 chr7:158797754 A/C cg07130601 chr7:158766826 NA 0.42 6.04 0.32 4.05e-9 Facial morphology (factor 20); CRC trans rs7819412 0.521 rs2409720 chr8:11037903 A/C cg16141378 chr3:129829833 LOC729375 0.43 6.28 0.33 1.08e-9 Triglycerides; CRC cis rs8062405 1.000 rs62037371 chr16:28890131 C/A cg08761264 chr16:28874980 SH2B1 -0.44 -5.83 -0.31 1.33e-8 Cognitive ability (multi-trait analysis);Cognitive ability; CRC cis rs17767392 0.813 rs61989379 chr14:71964406 G/C cg13720639 chr14:72061746 SIPA1L1 -0.5 -6.46 -0.34 3.81e-10 Mitral valve prolapse; CRC trans rs6703335 0.870 rs10803142 chr1:243598234 A/G cg10389584 chr19:12512226 ZNF799 0.45 6.53 0.34 2.55e-10 Schizophrenia;Schizophrenia, schizoaffective disorder or bipolar disorder; CRC cis rs13118159 0.550 rs10016557 chr4:1363628 C/T cg05025164 chr4:1340916 KIAA1530 -0.56 -7.88 -0.4 4.9e-14 Longevity; CRC cis rs1223397 0.589 rs2439540 chr6:13309342 G/A cg07912922 chr6:13274314 PHACTR1 0.41 6.32 0.33 8.45e-10 Blood pressure; CRC cis rs12477438 0.520 rs13009147 chr2:99803998 T/G cg14399236 chr2:99771627 LIPT1;TSGA10 0.8 13.97 0.61 3.96e-35 Chronic sinus infection; CRC cis rs4666002 0.956 rs3749147 chr2:27851918 G/A cg27432699 chr2:27873401 GPN1 0.44 5.63 0.3 3.81e-8 Phospholipid levels (plasma); CRC cis rs7172677 0.960 rs8026273 chr15:75413766 T/A cg14664628 chr15:75095509 CSK -0.49 -5.75 -0.3 2.06e-8 Systemic lupus erythematosus and Systemic sclerosis; CRC cis rs1448094 0.512 rs7137596 chr12:86239884 C/G cg25456477 chr12:86230367 RASSF9 0.32 5.64 0.3 3.58e-8 Major depressive disorder; CRC cis rs6693567 0.565 rs543179 chr1:150274610 G/A cg15654264 chr1:150340011 RPRD2 -0.37 -5.63 -0.3 3.93e-8 Migraine; CRC cis rs6831352 0.918 rs29001232 chr4:100046654 G/C cg13256891 chr4:100009986 ADH5 -0.66 -8.89 -0.44 4.04e-17 Alcohol dependence; CRC cis rs7811142 1.000 rs60478351 chr7:100089017 C/T cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.74 9.96 0.48 1.4e-20 Platelet count; CRC cis rs7618501 0.603 rs72942333 chr3:49986118 T/C cg05623727 chr3:50126028 RBM5 0.46 7.58 0.39 3.49e-13 Intelligence (multi-trait analysis); CRC cis rs250677 1.000 rs28173 chr5:148423573 C/T cg23229984 chr5:148520753 ABLIM3 0.46 6.59 0.34 1.78e-10 Breast cancer; CRC cis rs1862618 0.573 rs2034245 chr5:56243685 T/C cg18230493 chr5:56204884 C5orf35 0.87 11.98 0.55 1.1e-27 Initial pursuit acceleration; CRC cis rs1129187 0.837 rs3763236 chr6:42902508 C/T cg02359409 chr6:42947317 PEX6 0.48 7.32 0.37 1.9e-12 Alzheimer's disease in APOE e4+ carriers; CRC cis rs9287719 0.839 rs11683335 chr2:10756665 C/G cg00105475 chr2:10696890 NA 0.45 7.17 0.37 4.85e-12 Prostate cancer; CRC trans rs72766638 0.895 rs11795079 chr9:136930134 T/C cg09836344 chr4:1243392 C4orf42;CTBP1 -0.58 -6.25 -0.33 1.24e-9 Mosquito bite size; CRC cis rs10504229 1.000 rs58947041 chr8:58188934 G/A cg24829409 chr8:58192753 C8orf71 -0.68 -11.33 -0.53 2.43e-25 Developmental language disorder (linguistic errors); CRC trans rs34156428 0.591 rs12577561 chr11:16806296 C/T cg05563613 chr7:99070410 ZNF789 0.71 6.22 0.32 1.5e-9 Coronary artery disease; CRC cis rs2204008 0.658 rs11181310 chr12:38315963 C/A cg13010199 chr12:38710504 ALG10B 0.46 6.18 0.32 1.88e-9 Bladder cancer; CRC cis rs67311347 1.000 rs2276870 chr3:40499182 C/T cg24209194 chr3:40518798 ZNF619 -0.44 -6.57 -0.34 1.97e-10 Renal cell carcinoma; CRC cis rs2197308 0.626 rs6581156 chr12:37858731 C/A cg26384229 chr12:38710491 ALG10B -0.63 -9.64 -0.47 1.62e-19 Morning vs. evening chronotype; CRC cis rs1129187 0.755 rs7760250 chr6:42929839 G/A cg26304593 chr6:42947056 PEX6 -0.46 -6.87 -0.35 3.2e-11 Alzheimer's disease in APOE e4+ carriers; CRC cis rs7954584 0.567 rs11043243 chr12:122356370 G/C cg21171335 chr12:122356390 WDR66 0.4 6.12 0.32 2.72e-9 Mean corpuscular volume; CRC cis rs4654899 0.897 rs7545133 chr1:21206143 T/G cg02927042 chr1:21476669 EIF4G3 0.39 6.13 0.32 2.5e-9 Superior frontal gyrus grey matter volume; CRC cis rs798554 0.959 rs798557 chr7:2758982 G/A cg19717773 chr7:2847554 GNA12 -0.44 -6.36 -0.33 6.74e-10 Height; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg23998478 chr2:121269292 NA 0.24 5.98 0.31 5.81e-9 Liver disease severity in Alagille syndrome; CRC trans rs4942242 1.000 rs1105856 chr13:44227067 G/T cg19169023 chr15:41853346 TYRO3 0.53 7.89 0.4 4.48e-14 Response to tocilizumab in rheumatoid arthritis; CRC cis rs4664293 0.867 rs2357529 chr2:160595433 C/A cg08347373 chr2:160653686 CD302 -0.47 -7.43 -0.38 9.32e-13 Monocyte percentage of white cells; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg10268230 chr11:130731963 NA 0.42 6.89 0.36 2.76e-11 Liver disease severity in Alagille syndrome; CRC cis rs7412746 0.621 rs7518156 chr1:150945794 A/C cg10589385 chr1:150898437 SETDB1 0.27 5.68 0.3 2.99e-8 Melanoma; CRC cis rs4631830 0.657 rs2611502 chr10:51500301 A/G cg20129853 chr10:51489980 NA -0.44 -7.35 -0.38 1.57e-12 Prostate-specific antigen levels; CRC cis rs9549328 0.731 rs7983602 chr13:113620482 A/G cg25790453 chr13:113633590 MCF2L -0.54 -9.66 -0.47 1.32e-19 Systolic blood pressure; CRC cis rs35306767 0.903 rs765867 chr10:869901 G/T cg26597838 chr10:835615 NA 0.93 11.32 0.53 2.67e-25 Eosinophil percentage of granulocytes; CRC cis rs10504229 0.683 rs1495866 chr8:58141128 T/C cg04204079 chr8:58130323 NA -0.45 -5.78 -0.3 1.71e-8 Developmental language disorder (linguistic errors); CRC cis rs4713118 0.662 rs9468271 chr6:28024570 A/G cg03623178 chr6:28175578 NA 0.92 13.05 0.58 1.2e-31 Parkinson's disease; CRC cis rs6502050 0.835 rs9911379 chr17:80114529 A/G cg11859384 chr17:80120422 CCDC57 -0.36 -5.76 -0.3 1.9e-8 Life satisfaction; CRC trans rs7615952 0.641 rs4490307 chr3:125712676 T/G cg07211511 chr3:129823064 LOC729375 -0.78 -11.86 -0.55 3.04e-27 Blood pressure (smoking interaction); CRC cis rs7618915 0.571 rs12487445 chr3:52618319 A/C cg11645453 chr3:52864694 ITIH4 0.36 6.27 0.33 1.13e-9 Bipolar disorder; CRC cis rs728616 0.867 rs61860417 chr10:81734727 C/T cg11900509 chr10:81946545 ANXA11 -0.63 -6.41 -0.33 5.12e-10 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs1801251 1.000 rs6714245 chr2:233580505 T/C cg25237894 chr2:233734115 C2orf82 0.5 8.07 0.41 1.37e-14 Coronary artery disease; CRC cis rs8103278 0.507 rs3745802 chr19:46271177 G/T cg11657440 chr19:46296263 DMWD 0.72 12.88 0.58 5.24e-31 Coronary artery disease; CRC cis rs9322193 0.923 rs9322208 chr6:149979683 A/T cg00933542 chr6:150070202 PCMT1 0.29 5.91 0.31 8.72e-9 Lung cancer; CRC cis rs12142240 0.698 rs17361763 chr1:46810670 T/C cg00530320 chr1:46809349 NSUN4 0.58 7.95 0.4 3.09e-14 Menopause (age at onset); CRC cis rs6976053 0.935 rs7803865 chr7:100505792 C/T cg10426581 chr7:100472382 SRRT -0.39 -5.97 -0.31 6.1e-9 Plasminogen activator inhibitor type 1 levels (PAI-1); CRC cis rs3760982 1.000 rs3760983 chr19:44286660 C/T cg11993925 chr19:44307056 LYPD5 -0.46 -7.58 -0.39 3.44e-13 Breast cancer (estrogen-receptor negative);Breast cancer; CRC cis rs514406 0.607 rs6696940 chr1:53203427 C/T cg08859206 chr1:53392774 SCP2 0.42 6.57 0.34 1.97e-10 Monocyte count; CRC cis rs826838 0.935 rs1684407 chr12:39127270 C/T cg13010199 chr12:38710504 ALG10B -0.41 -5.84 -0.31 1.27e-8 Heart rate; CRC cis rs4665809 0.878 rs892448 chr2:26366205 A/G cg04944784 chr2:26401820 FAM59B -0.55 -6.56 -0.34 2.03e-10 Gut microbiome composition (summer); CRC cis rs2635047 0.967 rs2684820 chr18:44664304 G/A cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.42 6.86 0.35 3.52e-11 Educational attainment; CRC cis rs4713118 0.955 rs9393848 chr6:27688369 C/T cg03623178 chr6:28175578 NA 0.66 8.88 0.44 4.32e-17 Parkinson's disease; CRC trans rs2018683 0.600 rs6948880 chr7:29003478 C/T cg19402173 chr7:128379420 CALU -0.51 -7.45 -0.38 8.3e-13 Response to irinotecan and platinum-based chemotherapy in non-small-cell lung cancer; CRC cis rs75920871 0.588 rs1815788 chr11:116834971 T/C cg20608306 chr11:116969690 SIK3 -0.31 -5.72 -0.3 2.4e-8 Subjective well-being; CRC cis rs3806843 1.000 rs3733710 chr5:140167463 C/T cg16607685 chr5:140181889 PCDHA2;PCDHA1;PCDHA3 -0.26 -5.92 -0.31 8.06e-9 Depressive symptoms (multi-trait analysis); CRC cis rs8180040 0.587 rs62246398 chr3:47066203 A/C cg27129171 chr3:47204927 SETD2 -0.73 -11.53 -0.54 4.47e-26 Colorectal cancer; CRC cis rs10540 0.730 rs34690033 chr11:492677 G/C cg03934478 chr11:495069 RNH1 0.69 7.66 0.39 2.09e-13 Body mass index; CRC cis rs614226 0.872 rs787827 chr12:120937794 A/G cg27489772 chr12:121021490 NA 0.49 6.89 0.35 2.9e-11 Type 1 diabetes nephropathy; CRC trans rs12714314 0.560 rs11694545 chr2:1939208 C/T cg21011830 chr19:17970855 RPL18AP3;RPL18A 0.46 5.97 0.31 6.05e-9 Type 2 diabetes (age of onset); CRC cis rs3096299 0.933 rs2965824 chr16:89455306 A/G cg01788221 chr16:89496183 ANKRD11 -0.45 -6.68 -0.35 1.03e-10 Multiple myeloma (IgH translocation); CRC cis rs4665809 1.000 rs2384323 chr2:26306473 C/T cg22920501 chr2:26401640 FAM59B -0.52 -7.13 -0.37 6.3e-12 Gut microbiome composition (summer); CRC cis rs4731207 0.596 rs6466989 chr7:124690963 A/G cg23710748 chr7:124431027 NA -0.4 -6.28 -0.33 1.06e-9 Cutaneous malignant melanoma; CRC cis rs873946 0.648 rs12771651 chr10:134554482 C/A cg18305652 chr10:134549665 INPP5A 0.5 6.5 0.34 3.06e-10 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CRC cis rs7666738 0.830 rs11947027 chr4:99005941 T/C cg17366294 chr4:99064904 C4orf37 0.44 7.39 0.38 1.19e-12 Colonoscopy-negative controls vs population controls; CRC cis rs1707322 0.964 rs785509 chr1:46527300 G/A cg06784218 chr1:46089804 CCDC17 -0.55 -9.46 -0.46 6.32e-19 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs9309473 1.000 rs11899740 chr2:73631212 G/A cg20560298 chr2:73613845 ALMS1 -0.54 -6.16 -0.32 2.1e-9 Metabolite levels; CRC cis rs7666738 0.927 rs6832373 chr4:99051967 A/G cg17366294 chr4:99064904 C4orf37 0.45 7.59 0.39 3.35e-13 Colonoscopy-negative controls vs population controls; CRC cis rs10751667 0.666 rs7105477 chr11:964271 C/G cg06064525 chr11:970664 AP2A2 -0.29 -5.79 -0.3 1.63e-8 Alzheimer's disease (late onset); CRC cis rs1065656 0.581 rs1065663 chr16:1839023 G/A cg09830162 chr16:1889614 FAHD1;C16orf73 0.58 7.15 0.37 5.49e-12 Insulin-like growth factors; CRC cis rs6582630 0.502 rs10880388 chr12:38401341 A/T cg13010199 chr12:38710504 ALG10B 0.47 6.32 0.33 8.35e-10 Drug-induced liver injury (flucloxacillin); CRC cis rs6938 0.534 rs1130741 chr15:75189930 A/G cg18612461 chr15:75251733 NA 0.38 5.87 0.31 1.06e-8 Breast cancer; CRC cis rs1552244 1.000 rs3826 chr3:10141065 T/G cg18598329 chr3:10140678 FANCD2;C3orf24 -0.9 -13.24 -0.59 2.25e-32 Alzheimer's disease; CRC cis rs597539 0.652 rs611046 chr11:68631704 A/G cg04772025 chr11:68637568 NA 0.53 8.15 0.41 7.46e-15 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs896854 0.846 rs7845219 chr8:95937502 T/C cg16049864 chr8:95962084 TP53INP1 -0.64 -11.12 -0.52 1.3e-24 Type 2 diabetes; CRC cis rs1843834 0.539 rs12694643 chr2:225446603 A/G cg22509189 chr2:225307070 NA -0.39 -5.86 -0.31 1.09e-8 IgE levels in asthmatics (D.p. specific); CRC cis rs4665809 0.941 rs41285975 chr2:26351144 T/C cg04944784 chr2:26401820 FAM59B -0.6 -7.67 -0.39 1.98e-13 Gut microbiome composition (summer); CRC cis rs13118159 0.550 rs28614045 chr4:1374695 C/A cg02475777 chr4:1388615 CRIPAK 0.49 6.41 0.33 4.98e-10 Longevity; CRC cis rs1816752 1.000 rs7326932 chr13:25004493 A/T cg02811702 chr13:24901961 NA 0.47 6.47 0.34 3.45e-10 Obesity-related traits; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg26551688 chr8:103822898 NA 0.35 5.98 0.31 5.96e-9 Liver disease severity in Alagille syndrome; CRC cis rs877282 0.898 rs12357995 chr10:765739 T/C cg17470449 chr10:769945 NA 0.64 8.08 0.41 1.28e-14 Uric acid levels; CRC cis rs875971 1.000 rs1540651 chr7:65650121 C/T cg18876405 chr7:65276391 NA -0.53 -9.17 -0.45 5.48e-18 Aortic root size; CRC cis rs10504229 0.906 rs111838497 chr8:58185620 A/C cg22535103 chr8:58192502 C8orf71 -0.82 -12.27 -0.56 9.63e-29 Developmental language disorder (linguistic errors); CRC cis rs1355223 0.583 rs2941057 chr11:34882220 G/A cg24088639 chr11:34937564 PDHX;APIP -0.58 -8.51 -0.42 6.2e-16 Systemic lupus erythematosus and Systemic sclerosis; CRC cis rs9914988 0.943 rs1035989 chr17:27143810 T/G cg20469991 chr17:27169893 C17orf63 -0.59 -7.19 -0.37 4.48e-12 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs1218582 0.628 rs12130132 chr1:154880386 C/T cg06221963 chr1:154839813 KCNN3 -0.75 -12.79 -0.58 1.08e-30 Prostate cancer; CRC cis rs2011503 1.000 rs61744761 chr19:19656615 C/T cg11584989 chr19:19387371 SF4 0.55 5.92 0.31 8.24e-9 Bipolar disorder; CRC cis rs9322193 0.923 rs9479094 chr6:150046219 C/T cg00933542 chr6:150070202 PCMT1 0.29 5.98 0.31 5.8e-9 Lung cancer; CRC trans rs7615952 0.866 rs6438949 chr3:125650064 G/C cg02560186 chr11:3602584 NA -0.46 -6.39 -0.33 5.68e-10 Blood pressure (smoking interaction); CRC cis rs7811142 1.000 rs7809801 chr7:100072031 T/C cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.05 14.87 0.63 1.3e-38 Platelet count; CRC cis rs4481887 0.508 rs6666148 chr1:248402758 C/T cg00666640 chr1:248458726 OR2T12 0.38 6.45 0.33 4.03e-10 Common traits (Other); CRC cis rs9611565 0.512 rs139573 chr22:42214785 G/A cg06481639 chr22:41940642 POLR3H -0.63 -6.96 -0.36 1.86e-11 Vitiligo; CRC cis rs10221833 0.602 rs355887 chr2:165634262 T/C cg03182029 chr2:165697222 COBLL1 0.5 5.77 0.3 1.79e-8 Response to statin therapy; CRC cis rs9826463 0.757 rs113288103 chr3:142175321 C/T cg20824294 chr3:142316082 PLS1 0.42 6.86 0.35 3.37e-11 QRS duration in Tripanosoma cruzi seropositivity; CRC cis rs1577917 1.000 rs10455158 chr6:86672825 A/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.52 -6.78 -0.35 5.74e-11 Response to antipsychotic treatment; CRC cis rs34375054 0.573 rs12581367 chr12:125654641 T/C cg02766259 chr12:125626809 AACS -0.42 -6.26 -0.33 1.17e-9 Post bronchodilator FEV1/FVC ratio; CRC cis rs11190604 1.000 rs11190540 chr10:102202629 A/G cg16342193 chr10:102329863 NA -0.35 -5.76 -0.3 1.96e-8 Palmitoleic acid (16:1n-7) levels; CRC cis rs4072705 0.617 rs10283445 chr9:127243637 A/G cg13476313 chr9:127244764 NR5A1 0.29 5.97 0.31 6.04e-9 Menarche (age at onset); CRC cis rs950776 0.518 rs12594391 chr15:78816240 A/G cg06917634 chr15:78832804 PSMA4 0.67 10.63 0.51 7.01e-23 Sudden cardiac arrest; CRC cis rs1158570 0.564 rs2554372 chr8:131333913 A/G cg26053073 chr8:131455383 NA -0.4 -6.21 -0.32 1.62e-9 Platelet count; CRC trans rs7580658 0.614 rs7585198 chr2:127962635 C/T cg08541953 chr1:6259338 RPL22 -0.45 -6.29 -0.33 9.89e-10 Protein C levels; CRC cis rs743757 1.000 rs2282752 chr3:50433967 G/C cg08207895 chr3:50388901 TUSC4;CYB561D2 0.45 6.6 0.34 1.61e-10 Diastolic blood pressure; CRC cis rs2404602 0.692 rs67010831 chr15:76965308 T/G cg23625390 chr15:77176239 SCAPER 0.49 7.19 0.37 4.36e-12 Blood metabolite levels; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg04159381 chr1:53018615 ZCCHC11 0.39 6.1 0.32 3e-9 Liver disease severity in Alagille syndrome; CRC cis rs7617773 0.780 rs4479622 chr3:48338173 C/T cg11946769 chr3:48343235 NME6 0.73 9.93 0.48 1.73e-20 Coronary artery disease; CRC cis rs801193 0.660 rs2659897 chr7:66187715 A/G cg11764359 chr7:65958608 NA -0.59 -9.19 -0.45 4.44e-18 Aortic root size; CRC cis rs9517320 1.000 rs12864890 chr13:99126457 T/C cg07423050 chr13:99094983 FARP1 0.42 6.71 0.35 8.77e-11 Longevity; CRC cis rs6952808 0.723 rs4721282 chr7:2025040 A/G cg02951883 chr7:2050386 MAD1L1 -0.74 -12.27 -0.56 9.68e-29 Bipolar disorder and schizophrenia; CRC cis rs896854 0.530 rs10956934 chr8:95992473 C/A cg13393036 chr8:95962371 TP53INP1 -0.51 -8.49 -0.42 7.01e-16 Type 2 diabetes; CRC cis rs9443645 0.901 rs12193319 chr6:79583437 C/A cg09184832 chr6:79620586 NA -0.52 -9.73 -0.47 8.04e-20 Intelligence (multi-trait analysis); CRC cis rs7727544 1.000 rs7727038 chr5:131590257 C/T cg18758796 chr5:131593413 PDLIM4 0.34 6.38 0.33 5.87e-10 Blood metabolite levels; CRC cis rs9372498 0.505 rs9481789 chr6:118734320 A/C cg10217327 chr6:118973057 C6orf204 0.51 5.73 0.3 2.29e-8 Diastolic blood pressure; CRC cis rs10504229 1.000 rs59549824 chr8:58186205 A/C cg05313129 chr8:58192883 C8orf71 -0.47 -6.96 -0.36 1.83e-11 Developmental language disorder (linguistic errors); CRC cis rs9733 0.596 rs7418501 chr1:150711896 A/T cg15448220 chr1:150897856 SETDB1 0.44 6.22 0.32 1.47e-9 Tonsillectomy; CRC cis rs2032447 0.966 rs3752416 chr6:26045929 T/C cg26028573 chr6:26043587 HIST1H2BB 0.48 7.34 0.38 1.69e-12 Intelligence (multi-trait analysis); CRC cis rs939658 0.805 rs8035606 chr15:79420245 C/T cg17916960 chr15:79447300 NA -0.45 -7.4 -0.38 1.16e-12 Refractive error; CRC cis rs75920871 0.528 rs723955 chr11:116925042 G/A cg20608306 chr11:116969690 SIK3 -0.34 -6.46 -0.34 3.86e-10 Subjective well-being; CRC cis rs8180040 0.676 rs13098228 chr3:47138253 A/G cg27129171 chr3:47204927 SETD2 0.76 12.95 0.58 2.86e-31 Colorectal cancer; CRC cis rs1976403 0.659 rs10799700 chr1:21820968 G/C cg17800788 chr1:21766015 NBPF3 0.4 7.12 0.37 6.8e-12 Liver enzyme levels (alkaline phosphatase); CRC cis rs6762477 0.748 rs11717349 chr3:50223977 C/T cg05623727 chr3:50126028 RBM5 -0.41 -6.91 -0.36 2.48e-11 Menarche (age at onset); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg08247611 chr16:71928811 KIAA0174 0.47 6.57 0.34 1.98e-10 Response to antipsychotic treatment; CRC cis rs1712517 0.524 rs1712509 chr10:105013870 G/T cg04362960 chr10:104952993 NT5C2 -0.49 -6.39 -0.33 5.71e-10 Migraine; CRC cis rs1862618 0.853 rs252921 chr5:56137787 G/A cg20203395 chr5:56204925 C5orf35 -0.69 -8.2 -0.41 5.44e-15 Initial pursuit acceleration; CRC cis rs8016982 0.674 rs11850714 chr14:81662993 C/G cg01989461 chr14:81687754 GTF2A1 0.63 10.37 0.5 5.37e-22 Schizophrenia; CRC cis rs853679 0.517 rs9380057 chr6:28104634 G/T cg12172441 chr6:28176163 NA 0.62 7.4 0.38 1.17e-12 Depression; CRC cis rs6921919 0.609 rs9461455 chr6:28329731 C/T cg21251018 chr6:28226885 NKAPL 0.42 6.43 0.33 4.53e-10 Autism spectrum disorder or schizophrenia; CRC cis rs4654899 0.758 rs12402486 chr1:21447935 A/G cg02927042 chr1:21476669 EIF4G3 0.39 6.24 0.33 1.35e-9 Superior frontal gyrus grey matter volume; CRC cis rs12291225 0.679 rs11023170 chr11:14294909 A/G cg05501817 chr11:14380813 RRAS2 -0.45 -5.94 -0.31 7.15e-9 Sense of smell; CRC cis rs4555082 0.874 rs1008628 chr14:105722726 T/C cg06808227 chr14:105710500 BRF1 -0.63 -9.18 -0.45 4.97e-18 Mean platelet volume;Platelet distribution width; CRC cis rs9318086 0.935 rs9652080 chr13:24435426 A/C cg25267304 chr13:24462978 PCOTH;MIPEP -0.58 -9.43 -0.46 7.71e-19 Myopia (pathological); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg00252696 chr1:31769601 ZCCHC17;SNRNP40 0.4 6.25 0.33 1.3e-9 Liver disease severity in Alagille syndrome; CRC cis rs6089584 0.821 rs2273990 chr20:60579149 G/T cg06108461 chr20:60628389 TAF4 -0.71 -12.21 -0.56 1.53e-28 Body mass index; CRC cis rs921968 0.612 rs2384950 chr2:219499719 T/C cg02176678 chr2:219576539 TTLL4 0.5 8.39 0.42 1.48e-15 Mean corpuscular hemoglobin concentration; CRC cis rs796364 0.806 rs34381014 chr2:200916403 C/T cg25936922 chr2:200820526 C2orf60;C2orf47 -0.7 -6.57 -0.34 2.02e-10 Schizophrenia; CRC cis rs7259376 0.704 rs1897613 chr19:22573575 G/A cg02657401 chr19:22469223 NA -0.3 -6.61 -0.34 1.59e-10 Menopause (age at onset); CRC cis rs4953076 0.573 rs13008237 chr2:44404902 A/G cg04920474 chr2:44395004 PPM1B 0.57 7.75 0.39 1.14e-13 Height; CRC cis rs8067545 0.641 rs203466 chr17:19809953 C/G cg04132472 chr17:19861366 AKAP10 -0.4 -6.52 -0.34 2.7e-10 Schizophrenia; CRC cis rs2739330 0.761 rs5760176 chr22:24402321 A/G cg24846343 chr22:24311635 DDTL -0.66 -10.94 -0.52 5.72e-24 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs6582630 0.519 rs11181998 chr12:38439970 C/A cg26384229 chr12:38710491 ALG10B 0.7 9.8 0.48 4.54e-20 Drug-induced liver injury (flucloxacillin); CRC cis rs6988985 0.728 rs6471570 chr8:143957405 A/C cg10324643 chr8:143916377 GML 0.37 6.14 0.32 2.43e-9 Plasma androstenedione levels in resected early stage-receptor positive breast cancer; CRC cis rs1401999 0.966 rs4148585 chr3:183670642 A/G cg01324343 chr3:183735012 ABCC5 0.81 14.71 0.63 5.47e-38 Anterior chamber depth; CRC cis rs10504229 0.683 rs11786527 chr8:58131344 G/C cg24829409 chr8:58192753 C8orf71 -0.56 -8.14 -0.41 7.98e-15 Developmental language disorder (linguistic errors); CRC cis rs7605827 0.930 rs4668447 chr2:15516166 T/C cg19274914 chr2:15703543 NA 0.38 5.78 0.3 1.78e-8 Educational attainment (years of education); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg04798158 chr14:75179846 FCF1;KIAA0317 0.41 5.99 0.31 5.53e-9 Liver disease severity in Alagille syndrome; CRC cis rs7809950 1.000 rs10276604 chr7:107216738 C/T cg23024343 chr7:107201750 COG5 0.6 8.99 0.44 2e-17 Coronary artery disease; CRC cis rs654950 0.840 rs116241899 chr1:41994546 T/C cg06885757 chr1:42089581 HIVEP3 -0.33 -5.68 -0.3 2.99e-8 Airway imaging phenotypes; CRC cis rs8180040 0.966 rs6787422 chr3:47418509 G/T cg10298567 chr3:47292165 KIF9 -0.36 -5.91 -0.31 8.43e-9 Colorectal cancer; CRC cis rs11212617 0.967 rs6589017 chr11:108308504 A/G cg01991180 chr11:108092276 ATM;NPAT 0.42 6.05 0.32 3.98e-9 Response to metformin in type 2 diabetes (glycemic); CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg21514356 chr4:135865523 NA 0.37 6.11 0.32 2.74e-9 Diisocyanate-induced asthma; CRC cis rs763121 0.819 rs138700 chr22:39129999 A/G cg06022373 chr22:39101656 GTPBP1 0.78 12.63 0.57 4.45e-30 Menopause (age at onset); CRC cis rs1801251 1.000 rs36007169 chr2:233621834 A/G cg25237894 chr2:233734115 C2orf82 0.54 8.8 0.44 7.77e-17 Coronary artery disease; CRC cis rs11122272 0.735 rs2491412 chr1:231535880 A/T cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.54 -8.03 -0.4 1.73e-14 Hemoglobin concentration; CRC cis rs10197940 0.532 rs13425170 chr2:152387112 A/C cg06191203 chr2:152266755 RIF1 -0.64 -7.97 -0.4 2.59e-14 Lung cancer; CRC cis rs2204008 0.563 rs2320512 chr12:38266913 G/A cg13010199 chr12:38710504 ALG10B -0.41 -5.81 -0.31 1.47e-8 Bladder cancer; CRC cis rs4713118 0.662 rs149948 chr6:27974817 C/G cg15786705 chr6:28176104 NA 0.65 9.33 0.46 1.63e-18 Parkinson's disease; CRC cis rs13108904 0.967 rs62293658 chr4:1276416 T/C cg05665937 chr4:1216051 CTBP1 -0.36 -5.64 -0.3 3.75e-8 Obesity-related traits; CRC cis rs59043219 1 rs59043219 chr1:209970610 G/A cg22338127 chr1:209979572 IRF6 0.42 6.01 0.31 5.01e-9 Crohn's disease;Inflammatory bowel disease;Alzheimer's disease (APOE e4 interaction); CRC cis rs17155006 0.664 rs451252 chr7:107738948 G/A cg05962710 chr7:107745446 LAMB4 -0.43 -7.53 -0.38 4.79e-13 Pneumococcal bacteremia; CRC cis rs9467773 1.000 rs9357010 chr6:26527945 C/G cg09904177 chr6:26538194 HMGN4 0.83 14.06 0.61 1.67e-35 Intelligence (multi-trait analysis); CRC cis rs7927592 0.956 rs7116899 chr11:68385535 G/T cg01657329 chr11:68192670 LRP5 -0.46 -6.75 -0.35 6.64e-11 Total body bone mineral density; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg23721301 chr10:112064230 SMNDC1 0.46 7.27 0.37 2.71e-12 Intelligence (multi-trait analysis); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg26396086 chr1:247494708 ZNF496 0.36 6.23 0.32 1.4e-9 Liver disease severity in Alagille syndrome; CRC cis rs10504229 0.861 rs59873610 chr8:58172290 T/A cg05313129 chr8:58192883 C8orf71 -0.47 -7.0 -0.36 1.47e-11 Developmental language disorder (linguistic errors); CRC cis rs28386778 0.863 rs3760256 chr17:61821161 A/G cg00280220 chr17:61926910 NA 0.33 5.64 0.3 3.66e-8 Prudent dietary pattern; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg05828906 chr6:126278519 HINT3 0.47 6.01 0.31 4.91e-9 Thyroid stimulating hormone; CRC cis rs9640161 0.750 rs59211922 chr7:150023790 T/G cg13722127 chr7:150037890 RARRES2 0.48 7.97 0.4 2.63e-14 Blood protein levels;Circulating chemerin levels; CRC cis rs4722166 0.598 rs4722180 chr7:22805072 A/G cg05472934 chr7:22766657 IL6 0.64 10.39 0.5 4.59e-22 Lung cancer; CRC cis rs9649213 0.593 rs736753 chr7:97931489 G/T cg21770322 chr7:97807741 LMTK2 0.5 8.23 0.41 4.39e-15 Prostate cancer (SNP x SNP interaction); CRC cis rs9788333 0.762 rs4441120 chr13:21886863 T/A cg21970626 chr13:21893289 NA -0.46 -8.75 -0.43 1.1e-16 Thiazide-induced adverse metabolic effects in hypertensive patients; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg08651674 chr6:7108441 RREB1 0.47 6.07 0.32 3.55e-9 Thyroid stimulating hormone; CRC cis rs11105298 0.891 rs6538190 chr12:89885942 T/C cg08166232 chr12:89918718 WDR51B;GALNT4 -0.61 -7.81 -0.4 7.9e-14 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; CRC cis rs7777484 0.517 rs2644306 chr7:2831602 A/G cg19717773 chr7:2847554 GNA12 -0.5 -8.88 -0.44 4.35e-17 Height; CRC cis rs7412746 0.587 rs11204722 chr1:150730184 A/C cg15448220 chr1:150897856 SETDB1 -0.5 -6.99 -0.36 1.53e-11 Melanoma; CRC cis rs2882667 0.690 rs311597 chr5:138055901 A/G cg09476006 chr5:138032270 NA 0.56 9.7 0.47 9.69e-20 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs780096 0.526 rs72819536 chr2:27682850 G/T cg02592271 chr2:27665507 KRTCAP3 -0.27 -5.94 -0.31 7.17e-9 Total body bone mineral density; CRC cis rs13161895 1.000 rs35973843 chr5:179466502 T/C cg02702477 chr5:179499311 RNF130 0.55 6.26 0.33 1.18e-9 LDL cholesterol; CRC cis rs11148252 0.875 rs9596651 chr13:52938582 A/G cg02158880 chr13:53174818 NA -0.43 -6.54 -0.34 2.29e-10 Lewy body disease; CRC cis rs2396545 0.634 rs35788385 chr11:570094 G/A cg03909863 chr11:638404 DRD4 -0.45 -5.74 -0.3 2.18e-8 Systemic lupus erythematosus and Systemic sclerosis; CRC cis rs1065852 0.526 rs4822079 chr22:42394612 G/C cg00645731 chr22:42541494 CYP2D7P1 0.39 6.68 0.35 1.04e-10 Response to serotonin reuptake inhibitors in major depressive disorder (plasma drug and metabolite levels); CRC cis rs4730250 0.707 rs257377 chr7:106801088 G/T cg02696742 chr7:106810147 HBP1 -0.63 -6.71 -0.35 8.31e-11 Osteoarthritis; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg19701416 chr10:28592092 NA 0.55 7.33 0.37 1.82e-12 Thyroid stimulating hormone; CRC cis rs7259376 0.902 rs7248242 chr19:22575994 A/G cg02657401 chr19:22469223 NA 0.32 6.92 0.36 2.34e-11 Menopause (age at onset); CRC trans rs1005277 0.579 rs1614236 chr10:38502996 C/T cg23533926 chr12:111358616 MYL2 -0.55 -8.38 -0.42 1.6e-15 Extrinsic epigenetic age acceleration; CRC cis rs7605827 0.897 rs4668922 chr2:15675130 C/T cg19274914 chr2:15703543 NA 0.39 5.87 0.31 1.07e-8 Educational attainment (years of education); CRC cis rs6543140 0.964 rs1523205 chr2:103070176 G/T cg09003973 chr2:102972529 NA 0.41 5.77 0.3 1.85e-8 Blood protein levels; CRC cis rs10927875 0.541 rs1763601 chr1:16340460 G/T cg22431228 chr1:16359049 CLCNKA -0.37 -6.72 -0.35 8.23e-11 Dilated cardiomyopathy; CRC cis rs57590327 0.503 rs6802480 chr3:81906671 G/A cg07356753 chr3:81810745 GBE1 -0.63 -8.54 -0.43 5.14e-16 Extraversion; CRC cis rs9611565 0.765 rs202659 chr22:41811620 T/C cg03806693 chr22:41940476 POLR3H 0.98 12.29 0.56 7.67e-29 Vitiligo; CRC cis rs4654899 0.897 rs1021077 chr1:21106016 A/G cg02927042 chr1:21476669 EIF4G3 -0.44 -7.02 -0.36 1.31e-11 Superior frontal gyrus grey matter volume; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg17935035 chr15:40763388 CHST14 0.4 6.25 0.33 1.28e-9 Liver disease severity in Alagille syndrome; CRC cis rs3008870 1.000 rs2985797 chr1:67431499 C/T cg08660285 chr1:67390436 MIER1;WDR78 -1.01 -14.08 -0.61 1.45e-35 Lymphocyte percentage of white cells; CRC cis rs11148252 0.840 rs3886077 chr13:52949053 C/A cg12458913 chr13:53173898 NA 0.53 8.27 0.41 3.34e-15 Lewy body disease; CRC cis rs1580019 0.885 rs4460269 chr7:32496445 T/C cg07520158 chr7:32535189 LSM5;AVL9 0.45 6.48 0.34 3.4e-10 Cognitive ability; CRC cis rs947211 0.846 rs708726 chr1:205762139 G/T cg24503407 chr1:205819492 PM20D1 -0.42 -6.04 -0.32 4.13e-9 Parkinson's disease; CRC cis rs1401999 0.724 rs1016752 chr3:183665062 C/G cg01324343 chr3:183735012 ABCC5 -0.75 -11.87 -0.55 2.82e-27 Anterior chamber depth; CRC cis rs9914988 0.887 rs11650282 chr17:27090741 C/G cg12682573 chr17:27188876 MIR451;MIR144 0.58 7.98 0.4 2.43e-14 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs3617 0.591 rs11918800 chr3:52868145 G/A cg15147215 chr3:52552868 STAB1 0.53 9.17 0.45 5.29e-18 Red blood cell count;Autism spectrum disorder or schizophrenia; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg05824535 chr16:25117957 NA 0.46 7.58 0.39 3.58e-13 Liver disease severity in Alagille syndrome; CRC cis rs11711311 1.000 rs7622515 chr3:113472538 G/A cg15478005 chr3:113465772 ATP6V1A;NAA50 0.42 5.83 0.31 1.34e-8 IgG glycosylation; CRC cis rs561341 0.941 rs8081016 chr17:30331751 A/G cg12193833 chr17:30244370 NA -0.76 -8.88 -0.44 4.33e-17 Hip circumference adjusted for BMI; CRC cis rs7618501 0.633 rs7621026 chr3:49975334 A/G cg24308560 chr3:49941425 MST1R -0.52 -8.75 -0.43 1.11e-16 Intelligence (multi-trait analysis); CRC cis rs7727544 0.901 rs55633655 chr5:131598756 T/G cg18758796 chr5:131593413 PDLIM4 0.33 6.12 0.32 2.72e-9 Blood metabolite levels; CRC cis rs4073416 0.568 rs1121885 chr14:66156914 A/G cg03016385 chr14:66212404 NA -0.42 -5.91 -0.31 8.71e-9 N-glycan levels; CRC trans rs459571 0.920 rs460154 chr9:136909309 C/T cg15028160 chr19:49622717 PPFIA3;C19orf73 -0.55 -7.18 -0.37 4.54e-12 Platelet distribution width; CRC cis rs7089973 0.624 rs11196930 chr10:116583596 C/T cg23260525 chr10:116636907 FAM160B1 0.35 8.12 0.41 9.33e-15 Bipolar disorder or attention deficit hyperactivity disorder; CRC cis rs6502050 0.731 rs12150589 chr17:80158233 A/T cg02741985 chr17:80059408 CCDC57 0.42 6.99 0.36 1.51e-11 Life satisfaction; CRC cis rs4689388 0.889 rs13128674 chr4:6294517 C/T cg00701064 chr4:6280414 WFS1 0.75 13.24 0.59 2.21e-32 Type 2 diabetes and other traits;Type 2 diabetes; CRC cis rs9549367 0.789 rs9549701 chr13:113881752 G/C cg18105134 chr13:113819100 PROZ -0.73 -10.87 -0.51 1.05e-23 Platelet distribution width; CRC cis rs11650494 0.710 rs57030023 chr17:47468546 T/A cg08112188 chr17:47440006 ZNF652 0.68 6.12 0.32 2.65e-9 Prostate cancer; CRC cis rs10464366 0.912 rs7785889 chr7:39106368 G/T cg18850127 chr7:39170497 POU6F2 0.49 6.09 0.32 3.09e-9 IgG glycosylation; CRC cis rs10463316 0.779 rs1810084 chr5:150777048 A/G cg03212797 chr5:150827313 SLC36A1 -0.42 -6.52 -0.34 2.71e-10 Metabolite levels (Pyroglutamine); CRC cis rs367943 0.901 rs463167 chr5:112799369 C/A cg12552261 chr5:112820674 MCC -0.5 -7.78 -0.39 9.28e-14 Type 2 diabetes; CRC cis rs4481887 1.000 rs4916124 chr1:248466495 T/C cg13385794 chr1:248469461 NA 0.39 6.98 0.36 1.62e-11 Common traits (Other); CRC cis rs12476592 0.571 rs185499 chr2:63867523 G/T cg10828910 chr2:63850056 LOC388955 0.5 6.24 0.33 1.37e-9 Childhood ear infection; CRC trans rs7615952 0.932 rs1976458 chr3:125647512 T/G cg16558177 chr4:4109446 NA -0.48 -6.21 -0.32 1.62e-9 Blood pressure (smoking interaction); CRC cis rs4713118 0.869 rs9283882 chr6:27715258 A/C cg06470822 chr6:28175283 NA 0.72 10.34 0.5 6.75e-22 Parkinson's disease; CRC trans rs951252 0.504 rs11734405 chr4:146081096 C/T cg02654935 chr6:12514489 NA -0.5 -6.82 -0.35 4.47e-11 Hip circumference; CRC cis rs9527 0.662 rs10786714 chr10:104598606 G/C cg04362960 chr10:104952993 NT5C2 0.67 8.57 0.43 4.02e-16 Arsenic metabolism; CRC trans rs7179994 0.579 rs72712678 chr15:28301550 T/C cg05237436 chr5:138533428 SIL1 0.71 6.29 0.33 1.03e-9 Shingles; CRC cis rs6089584 0.854 rs6061407 chr20:60622048 A/C cg18761221 chr20:60518478 NA 0.44 7.13 0.37 6.5e-12 Body mass index; CRC cis rs769267 0.931 rs2965193 chr19:19454828 G/A cg02546618 chr19:19431379 KIAA0892;SF4 -0.48 -6.65 -0.34 1.22e-10 Tonsillectomy; CRC cis rs9916302 0.904 rs755500 chr17:37409865 C/T cg15445000 chr17:37608096 MED1 0.39 8.37 0.42 1.62e-15 Glomerular filtration rate (creatinine); CRC cis rs4722166 0.597 rs1554606 chr7:22768707 T/G cg26061582 chr7:22766209 IL6 0.53 8.71 0.43 1.53e-16 Lung cancer; CRC trans rs875971 0.660 rs2191268 chr7:66110224 C/T cg25883402 chr1:173837173 SNORD76;SNORD74;SNORD75;GAS5;ZBTB37 -0.41 -6.3 -0.33 9.51e-10 Aortic root size; CRC trans rs2303319 0.504 rs1006427 chr2:162592328 T/C cg23919916 chr10:103825097 HPS6 -0.69 -6.01 -0.31 4.8e-9 Cognitive function; CRC trans rs12663356 0.528 rs9350359 chr6:21462624 C/T cg13309018 chr9:130965761 CIZ1;DNM1 0.4 6.16 0.32 2.07e-9 Crohn's disease; CRC cis rs597539 0.652 rs602364 chr11:68662167 C/T cg06112835 chr11:68658793 MRPL21 0.47 7.64 0.39 2.35e-13 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs7959452 0.868 rs12812860 chr12:69746671 T/C cg22834771 chr12:69754056 YEATS4 -0.48 -7.09 -0.36 8.44e-12 Blood protein levels; CRC cis rs7527798 0.545 rs6696228 chr1:207846830 G/A cg21110645 chr1:207815933 NA -0.38 -5.66 -0.3 3.34e-8 Erythrocyte sedimentation rate; CRC cis rs875971 1.000 rs1183245 chr7:65541185 C/T cg11764359 chr7:65958608 NA -0.6 -9.5 -0.46 4.46e-19 Aortic root size; CRC cis rs9398803 0.865 rs2152876 chr6:126761228 A/G cg19875578 chr6:126661172 C6orf173 -0.42 -6.02 -0.32 4.64e-9 Male-pattern baldness; CRC cis rs12580194 1.000 rs12582734 chr12:55689572 C/A cg19537932 chr12:55886519 OR6C68 -0.6 -8.37 -0.42 1.68e-15 Cancer; CRC trans rs637571 0.726 rs526631 chr11:65681965 T/G cg17712092 chr4:129076599 LARP1B -0.74 -12.37 -0.56 3.98e-29 Eosinophil percentage of white cells; CRC cis rs7412746 0.646 rs10399947 chr1:150861960 G/A cg10589385 chr1:150898437 SETDB1 0.29 6.34 0.33 7.45e-10 Melanoma; CRC cis rs9649213 0.593 rs6465673 chr7:97968887 C/T cg00277769 chr7:97922759 BAIAP2L1 -0.59 -10.3 -0.49 9.23e-22 Prostate cancer (SNP x SNP interaction); CRC cis rs7615952 0.599 rs6779141 chr3:125709995 A/T cg06494592 chr3:125709126 NA -0.56 -6.61 -0.34 1.54e-10 Blood pressure (smoking interaction); CRC cis rs354225 0.597 rs10176445 chr2:54845776 G/C cg26097391 chr2:54893211 SPTBN1 0.38 5.66 0.3 3.38e-8 Schizophrenia; CRC cis rs11622475 1.000 rs11625697 chr14:104464800 C/T cg20488157 chr14:104394430 TDRD9 0.68 9.88 0.48 2.46e-20 Bipolar disorder; CRC cis rs9611565 0.579 rs73178621 chr22:41921665 A/G cg06481639 chr22:41940642 POLR3H -0.57 -6.53 -0.34 2.54e-10 Vitiligo; CRC cis rs748404 0.660 rs690367 chr15:43748304 C/T cg02155558 chr15:43621948 ADAL;LCMT2 -0.51 -7.28 -0.37 2.42e-12 Lung cancer; CRC cis rs9399135 0.967 rs2327580 chr6:135364417 A/C cg22676075 chr6:135203613 NA 0.39 6.08 0.32 3.38e-9 Red blood cell count; CRC cis rs12188164 0.762 rs11745923 chr5:475408 T/G cg17553881 chr5:443987 EXOC3;C5orf55 -0.37 -7.67 -0.39 1.94e-13 Cystic fibrosis severity; CRC cis rs11785400 0.793 rs4467920 chr8:143736846 C/T cg24634471 chr8:143751801 JRK 0.47 6.43 0.33 4.4e-10 Schizophrenia; CRC cis rs6460942 0.915 rs62448594 chr7:12442229 C/G cg10578991 chr7:12443926 VWDE -0.51 -5.61 -0.3 4.29e-8 Coronary artery disease; CRC cis rs1218582 0.772 rs877343 chr1:154910012 A/G cg16680214 chr1:154839983 KCNN3 -0.45 -8.8 -0.44 7.87e-17 Prostate cancer; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg09033691 chr11:10829409 EIF4G2 0.48 6.96 0.36 1.88e-11 Response to antipsychotic treatment; CRC cis rs9814567 0.806 rs1880374 chr3:134322113 G/A cg06541857 chr3:134203789 ANAPC13;CEP63 -0.37 -5.73 -0.3 2.3e-8 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs7849270 1.000 rs932833 chr9:131884041 T/A cg13538475 chr9:131942899 NA -0.29 -5.86 -0.31 1.13e-8 Blood metabolite ratios; CRC cis rs9399135 0.967 rs4895434 chr6:135293365 G/A cg22676075 chr6:135203613 NA 0.41 6.18 0.32 1.91e-9 Red blood cell count; CRC cis rs2836974 0.666 rs4818015 chr21:40675493 A/C cg22974920 chr21:40686053 BRWD1 0.45 6.33 0.33 7.89e-10 Cognitive function; CRC cis rs7215564 0.908 rs8076854 chr17:78663962 A/G cg09596252 chr17:78655493 RPTOR 0.56 6.11 0.32 2.76e-9 Myopia (pathological); CRC trans rs7395662 1.000 rs10838912 chr11:48496477 A/G cg21153622 chr11:89784906 NA -0.5 -8.0 -0.4 2.15e-14 HDL cholesterol; CRC cis rs10504229 1.000 rs72650887 chr8:58177343 G/A cg02290350 chr8:58132656 NA -0.42 -5.9 -0.31 9.22e-9 Developmental language disorder (linguistic errors); CRC trans rs9858542 0.953 rs9827708 chr3:49649989 C/G cg21582582 chr3:182698605 DCUN1D1 -0.56 -6.77 -0.35 6.07e-11 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg01153342 chr14:74254319 C14orf43 0.5 6.56 0.34 2.05e-10 Thyroid stimulating hormone; CRC cis rs6502050 0.835 rs34673303 chr17:80085144 G/C cg11859384 chr17:80120422 CCDC57 0.37 5.82 0.31 1.36e-8 Life satisfaction; CRC cis rs2832191 0.692 rs2776240 chr21:30310639 C/T cg24692254 chr21:30365293 RNF160 0.83 15.11 0.64 1.48e-39 Dental caries; CRC cis rs7833986 0.501 rs2976036 chr8:57031721 G/T cg23139584 chr8:56987506 RPS20;SNORD54 0.91 12.31 0.56 6.9e-29 Height; CRC cis rs7264396 0.513 rs2425092 chr20:34306815 T/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.48 -6.67 -0.35 1.06e-10 Total cholesterol levels; CRC cis rs1862618 0.671 rs2591955 chr5:56244948 C/T cg12311346 chr5:56204834 C5orf35 0.64 9.72 0.47 8.47e-20 Initial pursuit acceleration; CRC trans rs3733585 0.605 rs4235354 chr4:10122942 C/A cg26043149 chr18:55253948 FECH -0.51 -7.08 -0.36 8.98e-12 Cleft plate (environmental tobacco smoke interaction); CRC trans rs6462411 0.591 rs917198 chr7:3876866 A/T cg14000125 chr20:61704742 NA 0.34 6.33 0.33 7.8e-10 Quantitative traits; CRC cis rs9611565 0.659 rs9607812 chr22:41941243 G/A cg17554472 chr22:41940697 POLR3H -0.56 -6.07 -0.32 3.61e-9 Vitiligo; CRC cis rs35306767 0.807 rs61831436 chr10:837882 G/A cg20503657 chr10:835505 NA 1.26 15.21 0.64 6.08e-40 Eosinophil percentage of granulocytes; CRC cis rs490234 0.841 rs10114882 chr9:128303425 T/C cg14078157 chr9:128172775 NA -0.38 -6.41 -0.33 4.94e-10 Mean arterial pressure; CRC cis rs1552244 0.554 rs2272120 chr3:10046703 C/T cg02579736 chr3:10068473 FANCD2;CIDECP 0.66 9.24 0.45 3.11e-18 Alzheimer's disease; CRC cis rs6963495 0.818 rs117887993 chr7:105193837 T/G cg02135003 chr7:105160482 PUS7 -0.95 -12.62 -0.57 4.76e-30 Bipolar disorder (body mass index interaction); CRC cis rs7113874 0.589 rs10769910 chr11:8499406 T/C cg02811074 chr11:8615871 STK33 0.36 6.15 0.32 2.24e-9 Body mass index in physically active individuals;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs9398803 0.865 rs9372839 chr6:126809870 G/A cg19875578 chr6:126661172 C6orf173 0.42 5.86 0.31 1.15e-8 Male-pattern baldness; CRC cis rs4713675 0.565 rs4713668 chr6:33690796 C/T cg14003231 chr6:33640908 ITPR3 0.52 8.41 0.42 1.24e-15 Plateletcrit; CRC cis rs7618915 0.571 rs12632381 chr3:52607685 G/A cg07507251 chr3:52567010 NT5DC2 0.46 6.72 0.35 8.08e-11 Bipolar disorder; CRC trans rs561341 1.000 rs113676348 chr17:30244327 A/G cg20587970 chr11:113659929 NA -1.28 -18.07 -0.71 3.36e-51 Hip circumference adjusted for BMI; CRC cis rs172166 0.694 rs203884 chr6:28077374 G/T cg03623178 chr6:28175578 NA 0.78 11.64 0.54 1.85e-26 Cardiac Troponin-T levels; CRC cis rs4713118 0.826 rs2893929 chr6:27738732 A/T cg15845792 chr6:28175446 NA 0.7 7.65 0.39 2.28e-13 Parkinson's disease; CRC cis rs801193 0.761 rs2659888 chr7:66230171 T/G cg18876405 chr7:65276391 NA 0.59 10.55 0.5 1.35e-22 Aortic root size; CRC cis rs34172651 0.517 rs200526 chr16:24760511 C/T cg06028605 chr16:24865363 SLC5A11 -0.6 -9.96 -0.48 1.33e-20 Intelligence (multi-trait analysis); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg15636040 chr1:147142673 ACP6 0.43 6.29 0.33 9.89e-10 Intelligence (multi-trait analysis); CRC cis rs17641971 0.708 rs1511363 chr8:49901023 C/T cg00325661 chr8:49890786 NA 0.36 6.29 0.33 1.04e-9 Blood metabolite levels; CRC cis rs4888262 0.545 rs4588013 chr16:74703388 C/T cg01733217 chr16:74700730 RFWD3 0.79 12.03 0.55 6.99e-28 Testicular germ cell tumor; CRC cis rs780096 0.506 rs2950834 chr2:27627366 G/A cg12648201 chr2:27665141 KRTCAP3 -0.3 -5.91 -0.31 8.74e-9 Total body bone mineral density; CRC cis rs270601 0.690 rs162907 chr5:131580152 A/G cg09877947 chr5:131593287 PDLIM4 -0.58 -10.22 -0.49 1.83e-21 Acylcarnitine levels; CRC cis rs4713118 0.824 rs9468225 chr6:27745719 T/G cg08798685 chr6:27730294 NA -0.47 -6.48 -0.34 3.31e-10 Parkinson's disease; CRC cis rs10463316 0.894 rs13361298 chr5:150765549 T/C cg03212797 chr5:150827313 SLC36A1 -0.49 -7.7 -0.39 1.6e-13 Metabolite levels (Pyroglutamine); CRC cis rs1552244 0.572 rs3894322 chr3:10168965 G/A cg18598329 chr3:10140678 FANCD2;C3orf24 -0.9 -10.73 -0.51 3.19e-23 Alzheimer's disease; CRC cis rs736408 0.609 rs2230534 chr3:52802402 A/C cg08222913 chr3:52553049 STAB1 -0.35 -6.2 -0.32 1.73e-9 Bipolar disorder; CRC cis rs7493 0.901 rs2237586 chr7:95051052 G/T cg20119798 chr7:94954144 PON1 -0.52 -6.48 -0.34 3.39e-10 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs3733585 0.673 rs6843873 chr4:9958788 A/C cg11266682 chr4:10021025 SLC2A9 -0.48 -9.71 -0.47 9.14e-20 Cleft plate (environmental tobacco smoke interaction); CRC cis rs1448094 0.511 rs17279289 chr12:86162792 T/G cg18827107 chr12:86230957 RASSF9 -0.37 -5.73 -0.3 2.23e-8 Major depressive disorder; CRC cis rs6582630 0.519 rs8189549 chr12:38245752 A/G cg13010199 chr12:38710504 ALG10B 0.45 5.75 0.3 2.07e-8 Drug-induced liver injury (flucloxacillin); CRC cis rs10221833 0.602 rs355878 chr2:165633029 T/C cg03182029 chr2:165697222 COBLL1 0.5 5.79 0.3 1.64e-8 Response to statin therapy; CRC cis rs6951245 1.000 rs79443843 chr7:1075245 G/A cg18402987 chr7:1209562 NA 0.64 6.77 0.35 5.8200000000000003e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs501916 0.634 rs8037600 chr15:48060331 A/G cg16110827 chr15:48056943 SEMA6D -0.45 -6.62 -0.34 1.43e-10 Inflammatory bowel disease;Ulcerative colitis; CRC trans rs72793342 0.651 rs8050463 chr16:30554159 A/G cg10454327 chr16:85204789 NA -0.49 -6.33 -0.33 7.95e-10 RANTES levels; CRC trans rs4263408 0.934 rs9683743 chr4:39703194 A/C cg01112643 chr6:157802216 ZDHHC14 -0.48 -7.05 -0.36 1.05e-11 Plasma amyloid beta peptide concentrations (ABx-40); CRC cis rs9916302 0.808 rs12943928 chr17:37611330 G/A cg03013999 chr17:37608204 MED1 0.45 6.87 0.35 3.15e-11 Glomerular filtration rate (creatinine); CRC cis rs7927771 0.800 rs12146565 chr11:47398963 G/A cg18512352 chr11:47633146 NA -0.4 -7.65 -0.39 2.26e-13 Subjective well-being; CRC cis rs9916302 0.808 rs6503515 chr17:37606433 G/T cg07936489 chr17:37558343 FBXL20 -0.84 -13.1 -0.59 7.38e-32 Glomerular filtration rate (creatinine); CRC cis rs10751667 0.666 rs10902248 chr11:957742 A/G cg23136738 chr11:925521 AP2A2 -0.42 -7.23 -0.37 3.41e-12 Alzheimer's disease (late onset); CRC cis rs7224685 0.501 rs4790171 chr17:4022899 T/C cg21851534 chr17:3907994 ZZEF1 -0.36 -6.0 -0.31 5.34e-9 Type 2 diabetes; CRC cis rs6502050 0.814 rs62079997 chr17:80076888 C/T cg11859384 chr17:80120422 CCDC57 0.37 5.82 0.31 1.43e-8 Life satisfaction; CRC cis rs1218582 0.741 rs10908444 chr1:154840287 G/A cg24250549 chr1:154909240 PMVK 0.64 11.1 0.52 1.57e-24 Prostate cancer; CRC cis rs7617773 0.817 rs6801801 chr3:48326433 T/C cg11946769 chr3:48343235 NME6 0.64 8.91 0.44 3.49e-17 Coronary artery disease; CRC cis rs9467711 0.606 rs2073529 chr6:26375159 C/T cg16898833 chr6:26189333 HIST1H4D -0.74 -6.6 -0.34 1.68e-10 Autism spectrum disorder or schizophrenia; CRC trans rs10983614 1.000 rs7867776 chr9:120072627 A/G cg04427462 chr19:47218031 PRKD2 0.48 6.56 0.34 2.14e-10 Survival in pancreatic cancer; CRC cis rs1799949 1.000 rs2298862 chr17:41176688 T/C cg05368731 chr17:41323189 NBR1 0.69 10.12 0.49 3.81e-21 Menopause (age at onset); CRC cis rs951366 0.789 rs823097 chr1:205681370 G/A cg17178900 chr1:205818956 PM20D1 0.66 9.36 0.46 1.24e-18 Menarche (age at onset); CRC cis rs7208859 0.623 rs7208088 chr17:29143667 C/T cg13385521 chr17:29058706 SUZ12P 0.73 8.39 0.42 1.43e-15 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs9469578 1.000 rs9469578 chr6:33706479 C/T cg18708504 chr6:33715942 IP6K3 0.64 7.34 0.38 1.67e-12 Phosphorus levels; CRC cis rs270601 0.770 rs1007602 chr5:131602166 T/C cg18301423 chr5:131593218 PDLIM4 0.44 8.18 0.41 6.25e-15 Acylcarnitine levels; CRC cis rs2380220 1.000 rs9400318 chr6:95972381 T/A cg07718321 chr6:96025334 MANEA 0.51 5.98 0.31 5.83e-9 Behavioural disinhibition (generation interaction); CRC trans rs11098499 0.954 rs28429722 chr4:120300093 G/A cg25214090 chr10:38739885 LOC399744 0.62 9.74 0.47 7.35e-20 Corneal astigmatism; CRC cis rs2594989 0.836 rs347607 chr3:11268021 A/C cg00170343 chr3:11313890 ATG7 -0.53 -6.09 -0.32 3.23e-9 Circulating chemerin levels; CRC cis rs10746514 0.841 rs9725652 chr1:232245997 T/A cg09506761 chr1:232265262 NA 0.42 5.9 0.31 9.22e-9 Response to statin therapy; CRC cis rs4737010 0.630 rs569451 chr8:41623001 G/A cg17182837 chr8:41585554 ANK1 0.54 7.58 0.39 3.5e-13 Lymphocyte counts;High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Reticulocyte count;Reticulocyte fraction of red cells;Mean corpuscular volume;Immature fraction of reticulocytes;Mean corpuscular hemoglobin concentration; CRC cis rs6844506 1.000 rs4862357 chr4:185220362 C/T cg18317788 chr4:185205197 NA -0.41 -5.92 -0.31 8.05e-9 Gestational age at birth in premature rupture of membrane-initiated deliveries (child effect); CRC cis rs57221529 0.766 rs12521988 chr5:556421 C/T cg17948913 chr5:572064 NA 0.55 6.33 0.33 7.93e-10 Lung disease severity in cystic fibrosis; CRC cis rs1005277 0.579 rs1780138 chr10:38501654 A/G cg17219203 chr10:38645113 HSD17B7P2 -0.41 -5.93 -0.31 7.61e-9 Extrinsic epigenetic age acceleration; CRC cis rs60871478 1.000 rs62432860 chr7:807522 G/C cg04727924 chr7:799746 HEATR2 -0.45 -6.79 -0.35 5.27e-11 Cerebrospinal P-tau181p levels; CRC cis rs35264875 1.000 rs72928652 chr11:68851547 G/A cg03469862 chr11:68924853 NA 0.46 5.91 0.31 8.56e-9 Blond vs. brown hair color; CRC cis rs7943191 0.810 rs7942991 chr11:62337203 A/G cg13298116 chr11:62369859 EML3;MTA2 -0.57 -8.95 -0.44 2.58e-17 Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction); CRC cis rs2455601 1.000 rs7104661 chr11:8902501 C/G cg21881798 chr11:8931708 C11orf17;ST5 -0.55 -5.65 -0.3 3.46e-8 Schizophrenia; CRC cis rs919433 0.963 rs1896854 chr2:198147776 G/T cg20885578 chr2:198174922 NA -0.36 -6.31 -0.33 9.06e-10 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC cis rs6088580 0.634 rs3736762 chr20:33037336 C/T cg08999081 chr20:33150536 PIGU 0.61 11.56 0.54 3.73e-26 Glomerular filtration rate (creatinine); CRC cis rs8031584 0.958 rs11637469 chr15:31238783 T/C cg08109568 chr15:31115862 NA -0.54 -8.66 -0.43 2.2e-16 Huntington's disease progression; CRC cis rs4731207 0.698 rs962863 chr7:124558339 C/T cg23710748 chr7:124431027 NA 0.37 5.82 0.31 1.43e-8 Cutaneous malignant melanoma; CRC cis rs4862750 0.872 rs11947595 chr4:187899827 C/T cg10295955 chr4:187884368 NA -1.06 -28.72 -0.85 1.21e-91 Lobe attachment (rater-scored or self-reported); CRC cis rs4731207 0.565 rs7776744 chr7:124599749 A/G cg23710748 chr7:124431027 NA -0.42 -6.7 -0.35 8.82e-11 Cutaneous malignant melanoma; CRC trans rs11148252 0.583 rs9536048 chr13:52958788 T/C cg18335740 chr13:41363409 SLC25A15 0.48 6.38 0.33 5.84e-10 Lewy body disease; CRC cis rs311392 0.966 rs454975 chr8:55087514 T/C cg06042504 chr8:55087323 NA -0.42 -6.5 -0.34 2.97e-10 Pelvic organ prolapse (moderate/severe); CRC cis rs873946 0.648 rs12782123 chr10:134554662 G/A cg27286337 chr10:134555280 INPP5A 0.84 10.34 0.5 7.08e-22 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CRC cis rs9467773 0.583 rs2498380 chr6:26643996 C/G cg09904177 chr6:26538194 HMGN4 -0.68 -10.6 -0.5 8.56e-23 Intelligence (multi-trait analysis); CRC cis rs711245 0.518 rs11886145 chr2:36825716 C/G cg07416916 chr2:36825888 FEZ2 0.37 6.94 0.36 2.03e-11 Height; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg19741408 chr1:90460434 ZNF326;LOC492303 0.48 6.25 0.33 1.24e-9 Thyroid stimulating hormone; CRC trans rs9771228 0.930 rs10259431 chr7:32281397 C/T cg02979224 chr7:93204462 CALCR 0.34 5.96 0.31 6.43e-9 Cognitive ability;Verbal-numerical reasoning; CRC cis rs2067615 0.524 rs10778503 chr12:107090616 C/T cg15890332 chr12:107067104 RFX4 0.32 5.66 0.3 3.33e-8 Heart rate; CRC cis rs9910055 0.607 rs13726 chr17:42239561 C/T cg09913183 chr17:42254507 C17orf65;ASB16 0.59 8.56 0.43 4.52e-16 Total body bone mineral density; CRC cis rs7208859 0.673 rs9909497 chr17:29173228 C/A cg13385521 chr17:29058706 SUZ12P 0.69 8.02 0.4 1.81e-14 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs4819052 0.851 rs2838828 chr21:46663423 A/G cg02159808 chr21:46707872 POFUT2;LOC642852 0.5 6.59 0.34 1.76e-10 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs9916302 0.784 rs4795382 chr17:37700860 A/G cg07936489 chr17:37558343 FBXL20 -0.85 -13.29 -0.59 1.52e-32 Glomerular filtration rate (creatinine); CRC cis rs9486715 0.867 rs9373887 chr6:96957004 C/T cg18709589 chr6:96969512 KIAA0776 0.49 7.21 0.37 3.84e-12 Headache; CRC cis rs6761276 0.899 rs11891557 chr2:113835319 G/A cg09040174 chr2:113837401 NA 0.64 10.17 0.49 2.58e-21 Protein quantitative trait loci; CRC cis rs990171 0.607 rs1558642 chr2:102763960 T/G cg22835712 chr2:102737379 NA 0.46 6.01 0.31 4.97e-9 Lymphocyte counts; CRC cis rs7760949 0.889 rs9475816 chr6:13935425 T/C cg27413430 chr6:13925136 RNF182 0.33 5.76 0.3 1.91e-8 Mean corpuscular hemoglobin concentration; CRC cis rs7552404 0.765 rs211717 chr1:76106969 G/A cg03433033 chr1:76189801 ACADM -0.81 -11.14 -0.52 1.12e-24 Blood metabolite levels;Acylcarnitine levels; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg08023809 chr12:53645616 MFSD5 0.42 6.09 0.32 3.08e-9 Intelligence (multi-trait analysis); CRC cis rs9926296 0.533 rs12102297 chr16:89812762 C/A cg03388025 chr16:89894329 SPIRE2 0.42 8.33 0.42 2.27e-15 Vitiligo; CRC cis rs28386778 0.863 rs6919 chr17:61909485 A/T cg07362569 chr17:61921086 SMARCD2 -0.4 -6.21 -0.32 1.62e-9 Prudent dietary pattern; CRC cis rs10504229 1.000 rs949848 chr8:58169125 A/G cg21724239 chr8:58056113 NA 0.39 5.75 0.3 2.02e-8 Developmental language disorder (linguistic errors); CRC cis rs1552244 1.000 rs6768102 chr3:10149380 A/G cg00166722 chr3:10149974 C3orf24 0.69 9.19 0.45 4.43e-18 Alzheimer's disease; CRC cis rs713587 0.571 rs564667 chr2:25310860 A/T cg22495460 chr2:25135724 ADCY3 0.39 5.77 0.3 1.87e-8 Body mass index in non-asthmatics; CRC cis rs1215050 0.740 rs783932 chr4:98973936 C/G cg05340658 chr4:99064831 C4orf37 -0.48 -7.26 -0.37 2.75e-12 Waist-to-hip ratio adjusted for body mass index; CRC cis rs11608355 0.515 rs11613718 chr12:109912332 C/T cg05360138 chr12:110035743 NA 0.77 8.62 0.43 2.95e-16 Neuroticism; CRC cis rs3858526 0.527 rs10839168 chr11:6002798 A/G cg13902645 chr11:5959945 NA 0.45 6.88 0.35 3.11e-11 DNA methylation (variation); CRC cis rs73001065 0.636 rs28720066 chr19:19572220 G/T cg03709012 chr19:19516395 GATAD2A 0.81 6.69 0.35 9.4e-11 LDL cholesterol; CRC cis rs7927592 0.731 rs488381 chr11:68291693 G/A cg16797656 chr11:68205561 LRP5 -0.49 -9.05 -0.45 1.25e-17 Total body bone mineral density; CRC cis rs4689592 0.546 rs10937784 chr4:7060935 G/C cg06697600 chr4:7070879 GRPEL1 -0.49 -7.41 -0.38 1.09e-12 Monocyte percentage of white cells; CRC cis rs76878669 0.561 rs1039594 chr11:66131149 C/T cg18002602 chr11:66138449 SLC29A2 0.28 5.99 0.31 5.4e-9 Educational attainment (years of education); CRC cis rs9814567 1.000 rs1138273 chr3:134261437 T/C cg06541857 chr3:134203789 ANAPC13;CEP63 -0.4 -6.02 -0.31 4.76e-9 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs72781680 0.898 rs72780125 chr2:24000145 T/C cg08917208 chr2:24149416 ATAD2B 1.01 9.55 0.47 3.13e-19 Lymphocyte counts; CRC cis rs8180040 0.966 rs6792488 chr3:47503349 C/T cg02527881 chr3:46936655 PTH1R 0.38 7.07 0.36 9.43e-12 Colorectal cancer; CRC cis rs533581 0.866 rs4995274 chr16:88970040 T/C cg05579598 chr16:88989069 CBFA2T3 0.34 6.84 0.35 3.77e-11 Social autistic-like traits; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg20826379 chr1:16011358 PLEKHM2 0.46 6.45 0.34 4.02e-10 Response to antipsychotic treatment; CRC cis rs2197308 0.715 rs11181816 chr12:37911626 A/G cg26384229 chr12:38710491 ALG10B -0.62 -9.31 -0.46 1.88e-18 Morning vs. evening chronotype; CRC cis rs1799949 0.965 rs6503727 chr17:41312859 C/T cg25072359 chr17:41440525 NA 0.54 8.77 0.44 1e-16 Menopause (age at onset); CRC cis rs28386778 0.897 rs1043127 chr17:61791210 T/G cg06601766 chr17:61851465 DDX42;CCDC47 0.44 5.97 0.31 6.27e-9 Prudent dietary pattern; CRC trans rs2303319 0.504 rs62187612 chr2:162432494 A/G cg14875682 chr5:52083620 ITGA1;PELO -0.8 -6.48 -0.34 3.35e-10 Cognitive function; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg26351039 chr19:49138730 DBP 0.42 6.58 0.34 1.83e-10 Liver disease severity in Alagille syndrome; CRC cis rs8051149 0.738 rs2287120 chr16:87871582 G/A cg01412419 chr16:87856264 NA 0.52 7.06 0.36 9.73e-12 Blood metabolite levels; CRC cis rs2404602 0.536 rs12915248 chr15:76765615 A/T cg22467129 chr15:76604101 ETFA -0.38 -6.37 -0.33 6.44e-10 Blood metabolite levels; CRC cis rs7769051 1.000 rs73554431 chr6:133129922 T/G cg22852734 chr6:133119734 C6orf192 0.94 11.45 0.53 9.31e-26 Type 2 diabetes nephropathy; CRC trans rs1436351 0.683 rs6780872 chr3:104624448 A/C cg09862801 chr2:45396991 NA -0.48 -6.0 -0.31 5.27e-9 Body mass index; CRC cis rs7552404 0.627 rs12127049 chr1:76353248 G/A cg03433033 chr1:76189801 ACADM 0.72 8.64 0.43 2.54e-16 Blood metabolite levels;Acylcarnitine levels; CRC cis rs9346649 0.606 rs6940383 chr6:168491688 G/A cg02770688 chr6:168491649 NA 0.6 8.74 0.43 1.22e-16 Venous thromboembolism adjusted for sickle cell variant rs77121243-T; CRC cis rs995000 0.965 rs11207981 chr1:63006087 C/A cg19896129 chr1:63156450 NA -0.45 -6.99 -0.36 1.52e-11 Triglyceride levels; CRC cis rs2857891 0.659 rs2638110 chr11:6993922 C/T cg04053776 chr11:6947353 ZNF215 0.41 6.4 0.33 5.22e-10 Response to cytadine analogues (cytosine arabinoside); CRC cis rs2404602 0.622 rs11632365 chr15:77139080 G/A cg23625390 chr15:77176239 SCAPER -0.76 -9.77 -0.47 5.84e-20 Blood metabolite levels; CRC cis rs17826219 0.706 rs8071236 chr17:29100002 T/C cg13385521 chr17:29058706 SUZ12P 0.73 8.4 0.42 1.39e-15 Body mass index; CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg05952120 chr17:61554416 ACE 0.4 6.53 0.34 2.54e-10 Obesity-related traits; CRC cis rs10876993 0.821 rs1629032 chr12:58038686 C/T cg15848620 chr12:58087721 OS9 -0.61 -8.36 -0.42 1.79e-15 Celiac disease or Rheumatoid arthritis; CRC cis rs9462027 0.628 rs7769961 chr6:34760162 G/C cg07306190 chr6:34760872 UHRF1BP1 -0.35 -6.24 -0.33 1.31e-9 Systemic lupus erythematosus; CRC cis rs1976403 0.510 rs1697421 chr1:21823292 C/T cg17800788 chr1:21766015 NBPF3 0.37 6.3 0.33 9.45e-10 Liver enzyme levels (alkaline phosphatase); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg19374457 chr1:44412380 IPO13 0.38 6.28 0.33 1.05e-9 Liver disease severity in Alagille syndrome; CRC cis rs4308124 0.708 rs28766030 chr2:111962429 T/C cg04571233 chr2:111982156 NA -0.55 -8.2 -0.41 5.46e-15 Vitiligo; CRC cis rs9462027 0.628 rs58671447 chr6:34752351 A/G cg07306190 chr6:34760872 UHRF1BP1 -0.35 -6.24 -0.33 1.31e-9 Systemic lupus erythematosus; CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg27397625 chr6:42952298 PPP2R5D -0.49 -6.08 -0.32 3.3e-9 Diisocyanate-induced asthma; CRC cis rs6502050 0.835 rs7222057 chr17:80087647 C/A cg02741985 chr17:80059408 CCDC57 0.44 7.17 0.37 4.94e-12 Life satisfaction; CRC cis rs4481887 0.927 rs4537599 chr1:248508741 G/A cg13385794 chr1:248469461 NA 0.38 6.56 0.34 2.15e-10 Common traits (Other); CRC cis rs7072216 0.763 rs4475861 chr10:100164989 C/T cg26618903 chr10:100175079 PYROXD2 -0.52 -8.72 -0.43 1.37e-16 Metabolite levels; CRC cis rs62458065 1.000 rs10246687 chr7:32465183 T/A cg20159608 chr7:32802032 NA -0.5 -6.31 -0.33 8.83e-10 Metabolite levels (HVA/MHPG ratio); CRC cis rs9467711 0.606 rs66827971 chr6:26365766 T/C cg16898833 chr6:26189333 HIST1H4D 0.76 6.58 0.34 1.88e-10 Autism spectrum disorder or schizophrenia; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg04971341 chr1:52607910 ZFYVE9 0.47 6.65 0.34 1.26e-10 Response to antipsychotic treatment; CRC trans rs7944735 0.507 rs10838802 chr11:48102478 A/G cg15704280 chr7:45808275 SEPT13 0.63 8.57 0.43 3.98e-16 Intraocular pressure; CRC cis rs4481887 0.676 rs7527991 chr1:248527649 T/A cg00666640 chr1:248458726 OR2T12 0.35 6.65 0.34 1.24e-10 Common traits (Other); CRC cis rs3820068 0.580 rs7512308 chr1:16006604 C/A cg27534772 chr1:16042836 PLEKHM2 0.54 10.08 0.49 5.46e-21 Systolic blood pressure; CRC cis rs739401 0.588 rs10219272 chr11:3020789 G/A cg08508325 chr11:3079039 CARS -0.5 -9.36 -0.46 1.29e-18 Longevity; CRC trans rs6951245 0.935 rs118132455 chr7:1068232 C/A cg13565492 chr6:43139072 SRF -0.71 -7.31 -0.37 2.04e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs6087990 0.899 rs6058893 chr20:31392777 C/T cg13636640 chr20:31349939 DNMT3B 0.84 17.66 0.7 1.49e-49 Ulcerative colitis; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg14192396 chr10:97416393 ALDH18A1 0.46 6.15 0.32 2.3e-9 Anxiety disorder; CRC cis rs1383484 0.545 rs9329363 chr15:84643134 T/G cg11189052 chr15:85197271 WDR73 -0.49 -6.05 -0.32 3.93e-9 Height; CRC cis rs17826219 0.706 rs8071236 chr17:29100002 T/C cg01831904 chr17:28903510 LRRC37B2 -0.63 -6.45 -0.33 4.07e-10 Body mass index; CRC trans rs561341 1.000 rs68140514 chr17:30335781 T/C cg27661571 chr11:113659931 NA -0.75 -9.23 -0.45 3.32e-18 Hip circumference adjusted for BMI; CRC cis rs9868809 0.764 rs41290686 chr3:48604059 G/A cg01304814 chr3:48885189 PRKAR2A 0.9 5.9 0.31 9.14e-9 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; CRC cis rs798554 0.836 rs798526 chr7:2775542 G/C cg14895029 chr7:2775587 GNA12 -0.48 -7.23 -0.37 3.34e-12 Height; CRC cis rs34779708 0.677 rs112355105 chr10:35550294 A/T cg03585969 chr10:35415529 CREM 0.5 6.49 0.34 3.17e-10 Inflammatory bowel disease;Crohn's disease; CRC cis rs7618915 0.501 rs3733039 chr3:52719088 C/T cg10802521 chr3:52805072 NEK4 -0.58 -9.11 -0.45 8.18e-18 Bipolar disorder; CRC cis rs6921919 0.583 rs12697938 chr6:28341099 T/C cg21251018 chr6:28226885 NKAPL 0.4 6.09 0.32 3.12e-9 Autism spectrum disorder or schizophrenia; CRC trans rs617791 0.508 rs1047464 chr11:65769456 A/T cg17712092 chr4:129076599 LARP1B -0.47 -6.81 -0.35 4.69e-11 Breast cancer; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg11424665 chr3:129158811 IFT122;MBD4 0.37 6.22 0.32 1.49e-9 Liver disease severity in Alagille syndrome; CRC cis rs317689 0.918 rs581911 chr12:69738293 C/T cg14784868 chr12:69753453 YEATS4 0.57 7.07 0.36 9.15e-12 Response to diuretic therapy; CRC cis rs13108904 0.518 rs4974603 chr4:1343168 C/T cg21620606 chr4:1342894 KIAA1530 0.51 8.52 0.43 5.68e-16 Obesity-related traits; CRC cis rs6502050 0.835 rs7503225 chr17:80099639 C/A cg02741985 chr17:80059408 CCDC57 0.43 7.15 0.37 5.66e-12 Life satisfaction; CRC cis rs7772486 0.641 rs67882056 chr6:146416301 T/C cg13319975 chr6:146136371 FBXO30 -0.53 -7.45 -0.38 8.18e-13 Lobe attachment (rater-scored or self-reported); CRC cis rs7626444 0.625 rs843541 chr3:196475750 A/G cg12930392 chr3:196481615 PAK2 0.4 7.26 0.37 2.74e-12 Monocyte count; CRC cis rs910316 0.646 rs11546525 chr14:75537381 C/T cg06998765 chr14:75389618 RPS6KL1 -0.25 -5.74 -0.3 2.11e-8 Height; CRC cis rs7725052 0.609 rs4559044 chr5:40452857 A/G cg09067459 chr5:40385259 NA -0.4 -6.68 -0.35 9.91e-11 Pediatric autoimmune diseases; CRC cis rs870825 0.929 rs2310102 chr4:185595141 C/G cg04058563 chr4:185651563 MLF1IP -0.55 -5.89 -0.31 9.48e-9 Blood protein levels; CRC cis rs7918232 0.830 rs10764672 chr10:27392541 A/C cg14442939 chr10:27389572 ANKRD26 -0.74 -8.83 -0.44 6.42e-17 Breast cancer; CRC cis rs9868809 0.772 rs73078349 chr3:48688114 G/A cg01304814 chr3:48885189 PRKAR2A 0.79 5.77 0.3 1.85e-8 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; CRC cis rs10979 1.000 rs9399447 chr6:143896163 T/A cg25407410 chr6:143891975 LOC285740 -0.84 -13.84 -0.61 1.22e-34 Hypospadias; CRC cis rs7085104 0.700 rs743572 chr10:104597152 A/G cg08772003 chr10:104629869 AS3MT -0.34 -5.88 -0.31 9.88e-9 Immature fraction of reticulocytes;Schizophrenia; CRC cis rs4819052 0.851 rs10470246 chr21:46659017 C/G cg02159808 chr21:46707872 POFUT2;LOC642852 0.49 6.44 0.33 4.36e-10 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs992157 0.764 rs2015863 chr2:219185161 C/T cg04880052 chr2:219191631 PNKD -0.45 -6.77 -0.35 6.06e-11 Colorectal cancer; CRC cis rs12586317 0.547 rs74243586 chr14:35477325 C/T cg05294307 chr14:35346193 BAZ1A -0.72 -7.89 -0.4 4.61e-14 Psoriasis; CRC cis rs1223397 0.702 rs1223400 chr6:13271242 T/C cg21538684 chr6:13274180 PHACTR1 0.48 5.86 0.31 1.13e-8 Blood pressure; CRC cis rs9584850 0.718 rs6491427 chr13:99113166 A/G cg07423050 chr13:99094983 FARP1 0.45 6.31 0.33 9.26e-10 Neuroticism; CRC cis rs7843479 0.509 rs3758156 chr8:21770796 A/G cg16476235 chr8:21771668 DOK2 0.41 6.95 0.36 1.97e-11 Mean corpuscular volume; CRC trans rs9650657 0.615 rs7012199 chr8:10696997 A/C cg06636001 chr8:8085503 FLJ10661 -0.39 -6.04 -0.32 4.22e-9 Neuroticism; CRC cis rs6952808 0.723 rs11765550 chr7:2027324 G/A cg02951883 chr7:2050386 MAD1L1 -0.79 -12.92 -0.58 3.65e-31 Bipolar disorder and schizophrenia; CRC cis rs2019137 0.836 rs4848318 chr2:113953952 T/C cg11763394 chr2:113992921 PAX8;LOC440839;LOC654433 -0.5 -7.2 -0.37 4.22e-12 Lymphocyte counts; CRC cis rs375066 0.935 rs10421518 chr19:44381286 A/G cg12072164 chr19:44306565 LYPD5 0.37 5.61 0.3 4.36e-8 Breast cancer; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg12876261 chr7:56119223 PSPH;CCT6A 0.37 6.03 0.32 4.3e-9 Liver disease severity in Alagille syndrome; CRC cis rs9462846 1.000 rs2092555 chr6:42863842 C/G cg02353165 chr6:42928485 GNMT 0.49 6.68 0.35 1.01e-10 Blood protein levels; CRC cis rs2249694 0.919 rs2987794 chr10:135378612 G/T cg16964102 chr10:135390573 NA -0.37 -5.98 -0.31 5.78e-9 Obesity-related traits; CRC trans rs2795502 1.000 rs2795503 chr10:43347224 T/A cg06791473 chr12:49259579 RND1 0.62 6.08 0.32 3.32e-9 Blood protein levels; CRC cis rs2635047 0.638 rs2571006 chr18:44718515 G/T cg19077165 chr18:44547161 KATNAL2 -0.43 -6.8 -0.35 5.08e-11 Educational attainment; CRC cis rs11758351 0.734 rs56220351 chr6:26206884 A/G cg22723502 chr6:26240528 HIST1H4F -0.38 -6.22 -0.32 1.52e-9 Gout;Renal underexcretion gout; CRC cis rs12791968 0.527 rs12285862 chr11:45014326 T/G cg11846598 chr11:44996168 LOC221122 -0.51 -6.53 -0.34 2.52e-10 Inhibitory control; CRC cis rs6912958 0.781 rs4334949 chr6:88290150 G/A cg08069147 chr6:88032118 GJB7;C6orf162 -0.57 -8.58 -0.43 3.68e-16 Monocyte percentage of white cells; CRC cis rs362272 0.545 rs3129308 chr4:3309272 C/T cg11522145 chr4:3412961 RGS12 -0.41 -6.45 -0.33 4.03e-10 Serum sulfate level; CRC cis rs514406 0.560 rs1889033 chr1:53211887 A/G cg27535305 chr1:53392650 SCP2 0.34 6.17 0.32 2.03e-9 Monocyte count; CRC cis rs9902453 1.000 rs59274738 chr17:28437635 C/A cg26525008 chr17:28256777 EFCAB5;SSH2 0.59 8.87 0.44 4.59e-17 Coffee consumption (cups per day); CRC cis rs1555322 0.530 rs932562 chr20:33871310 T/C cg08210727 chr20:33865349 NA 0.44 6.06 0.32 3.7e-9 Attention deficit hyperactivity disorder; CRC cis rs6963495 0.818 rs6944787 chr7:105147309 C/T cg13798780 chr7:105162888 PUS7 0.66 8.06 0.41 1.39e-14 Bipolar disorder (body mass index interaction); CRC cis rs10089 1.000 rs59484271 chr5:127503781 C/T cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.64 8.28 0.42 3.2e-15 Ileal carcinoids; CRC cis rs1799949 0.931 rs34474989 chr17:41445410 A/T cg19454999 chr17:41278357 BRCA1;NBR2 0.42 6.57 0.34 1.92e-10 Menopause (age at onset); CRC cis rs6088580 0.524 rs6087612 chr20:33230822 T/G cg08999081 chr20:33150536 PIGU -0.37 -5.61 -0.3 4.22e-8 Glomerular filtration rate (creatinine); CRC cis rs2153535 0.580 rs6921036 chr6:8455400 G/A cg07606381 chr6:8435919 SLC35B3 0.67 10.72 0.51 3.51e-23 Motion sickness; CRC cis rs6867032 0.958 rs4975798 chr5:2015580 G/A cg26168224 chr5:2018326 NA 1.0 18.55 0.71 4.56e-53 Gut microbiome composition (winter); CRC cis rs17127169 0.536 rs112625995 chr1:65496627 A/G cg11989330 chr1:65468827 NA 0.89 6.32 0.33 8.3e-10 Sitting height ratio; CRC cis rs4819052 0.851 rs4818768 chr21:46659818 T/A cg02159808 chr21:46707872 POFUT2;LOC642852 0.49 6.41 0.33 5.19e-10 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs7552404 0.731 rs12078299 chr1:76365764 T/A cg03433033 chr1:76189801 ACADM 0.73 8.72 0.43 1.44e-16 Blood metabolite levels;Acylcarnitine levels; CRC cis rs10927875 0.541 rs1739841 chr1:16342727 A/G cg22431228 chr1:16359049 CLCNKA -0.38 -6.91 -0.36 2.52e-11 Dilated cardiomyopathy; CRC trans rs6678914 0.966 rs12033460 chr1:202180214 A/G cg19977628 chr5:1262072 TERT 0.42 5.99 0.31 5.37e-9 Breast cancer (estrogen-receptor negative);Breast cancer; CRC cis rs447735 0.566 rs258337 chr16:89720710 T/A cg03605463 chr16:89740564 NA 0.45 7.2 0.37 4.14e-12 Hemoglobin concentration; CRC cis rs7849270 1.000 rs7036114 chr9:131893406 C/T cg13538475 chr9:131942899 NA -0.31 -6.03 -0.32 4.33e-9 Blood metabolite ratios; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg13035437 chr7:30634158 GARS 0.4 6.43 0.33 4.42e-10 Intelligence (multi-trait analysis); CRC cis rs1129187 0.755 rs2274514 chr6:42934500 C/T cg03790207 chr6:42947109 PEX6 -0.53 -7.75 -0.39 1.17e-13 Alzheimer's disease in APOE e4+ carriers; CRC cis rs908922 0.676 rs7529136 chr1:152516389 T/C cg09873164 chr1:152488093 CRCT1 0.37 6.18 0.32 1.88e-9 Hair morphology; CRC cis rs4737010 0.591 rs13282514 chr8:41619713 A/G cg17182837 chr8:41585554 ANK1 -0.5 -7.32 -0.37 1.92e-12 Lymphocyte counts;High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Reticulocyte count;Reticulocyte fraction of red cells;Mean corpuscular volume;Immature fraction of reticulocytes;Mean corpuscular hemoglobin concentration; CRC cis rs2836974 0.666 rs2836975 chr21:40663620 A/G cg11644478 chr21:40555479 PSMG1 -0.69 -11.28 -0.53 3.7e-25 Cognitive function; CRC cis rs6500395 1.000 rs11076573 chr16:48632758 A/G cg04672837 chr16:48644449 N4BP1 0.46 6.86 0.35 3.46e-11 Response to tocilizumab in rheumatoid arthritis; CRC cis rs9291683 1.000 rs9291683 chr4:10324160 C/T cg00071950 chr4:10020882 SLC2A9 0.52 9.46 0.46 6.27e-19 Bone mineral density; CRC trans rs9825823 0.617 rs2083264 chr3:61074229 A/G cg16211334 chr6:10695274 C6orf52;PAK1IP1 0.39 6.07 0.32 3.62e-9 Depressive symptom measurement or major depressive disorder; CRC cis rs2573652 0.722 rs8034841 chr15:100541593 G/T cg00587665 chr15:100533223 ADAMTS17 -0.4 -7.03 -0.36 1.17e-11 Height; CRC cis rs294883 0.826 rs9355265 chr6:159701137 C/T cg14500486 chr6:159655392 FNDC1 -0.35 -5.75 -0.3 2.09e-8 Coronary artery disease; CRC cis rs9400239 0.661 rs1268162 chr6:109009194 A/G cg11073813 chr6:109029018 NA -0.42 -6.82 -0.35 4.5e-11 Waist circumference;Body mass index;BMI (adjusted for smoking behaviour); CRC cis rs1552244 0.808 rs7615088 chr3:10035896 A/T cg08888203 chr3:10149979 C3orf24 0.62 8.3 0.42 2.65e-15 Alzheimer's disease; CRC cis rs909002 0.849 rs871634 chr1:32093167 G/C cg13919466 chr1:32135498 COL16A1 -0.31 -5.98 -0.31 5.78e-9 Intelligence (multi-trait analysis); CRC trans rs2303319 0.504 rs62189046 chr2:162612371 C/G cg12500891 chr11:57225987 NA -0.65 -6.06 -0.32 3.77e-9 Cognitive function; CRC cis rs2251381 0.741 rs2735966 chr21:30538174 G/A cg08807101 chr21:30365312 RNF160 0.64 9.47 0.46 5.62e-19 Selective IgA deficiency; CRC cis rs10540 0.915 rs35389167 chr11:460765 A/G cg03352830 chr11:487213 PTDSS2 0.67 7.86 0.4 5.71e-14 Body mass index; CRC cis rs7726839 0.561 rs4957048 chr5:583442 G/A cg09021430 chr5:549028 NA -0.86 -10.93 -0.52 6.42e-24 Obesity-related traits; CRC cis rs4595586 0.525 rs17464772 chr12:39247777 G/A cg26384229 chr12:38710491 ALG10B 0.52 6.39 0.33 5.64e-10 Morning vs. evening chronotype; CRC cis rs11792861 0.781 rs874864 chr9:111728718 C/T cg14432460 chr9:111696404 IKBKAP;C9orf6 0.45 6.06 0.32 3.69e-9 Menarche (age at onset); CRC cis rs2463822 1.000 rs1881534 chr11:62085083 A/G cg06239285 chr11:62104954 ASRGL1 0.98 10.87 0.51 9.87e-24 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs9515201 0.859 rs9515199 chr13:111033704 C/T cg05272587 chr13:111038400 COL4A2 0.45 7.33 0.37 1.78e-12 White matter hyperintensity burden; CRC cis rs4268898 0.760 rs7597919 chr2:24563646 A/G cg06627628 chr2:24431161 ITSN2 0.43 6.2 0.32 1.68e-9 Asthma; CRC cis rs11148252 0.774 rs7334583 chr13:52930352 G/T cg02158880 chr13:53174818 NA -0.47 -7.07 -0.36 9.39e-12 Lewy body disease; CRC cis rs4731207 0.596 rs10264288 chr7:124574527 A/G cg23710748 chr7:124431027 NA -0.39 -6.09 -0.32 3.17e-9 Cutaneous malignant melanoma; CRC trans rs2243480 1.000 rs34193460 chr7:65393110 A/G cg10756647 chr7:56101905 PSPH 0.72 7.65 0.39 2.27e-13 Diabetic kidney disease; CRC cis rs2290405 0.527 rs4690332 chr4:910520 C/T cg09237302 chr4:906077 GAK 0.46 8.37 0.42 1.62e-15 Systemic sclerosis; CRC cis rs13108904 0.517 rs13128825 chr4:1334007 G/A cg21620606 chr4:1342894 KIAA1530 0.51 8.16 0.41 7.43e-15 Obesity-related traits; CRC cis rs2857891 0.909 rs56026267 chr11:6940211 T/C cg14883916 chr11:6947541 ZNF215 0.59 6.26 0.33 1.21e-9 Response to cytadine analogues (cytosine arabinoside); CRC cis rs9467773 0.838 rs3734540 chr6:26463321 A/C cg09904177 chr6:26538194 HMGN4 0.69 10.52 0.5 1.68e-22 Intelligence (multi-trait analysis); CRC cis rs4727027 0.899 rs11768971 chr7:148825826 C/G cg23583168 chr7:148888333 NA -0.93 -16.32 -0.67 2.74e-44 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC trans rs116095464 0.558 rs9688136 chr5:229348 T/C cg00938859 chr5:1591904 SDHAP3 0.72 7.96 0.4 2.76e-14 Breast cancer; CRC trans rs11088226 0.645 rs2409457 chr21:33929895 T/C cg09050820 chr6:167586206 TCP10L2 0.85 9.15 0.45 6.24e-18 Gastritis; CRC cis rs4803468 1.000 rs284651 chr19:41928336 T/C cg09537434 chr19:41945824 ATP5SL -0.97 -18.39 -0.71 1.96e-52 Height; CRC cis rs929354 1.000 rs1182378 chr7:157048322 T/C cg17757837 chr7:157058334 UBE3C -0.81 -14.78 -0.63 3e-38 Body mass index; CRC trans rs11098499 0.754 rs1546503 chr4:120241167 T/C cg25214090 chr10:38739885 LOC399744 0.54 8.48 0.42 7.86e-16 Corneal astigmatism; CRC cis rs9487051 0.676 rs7773775 chr6:109600339 T/C cg01475377 chr6:109611718 NA -0.37 -6.54 -0.34 2.41e-10 Reticulocyte fraction of red cells; CRC trans rs9329221 0.905 rs17765901 chr8:10249480 G/T cg08975724 chr8:8085496 FLJ10661 -0.43 -6.69 -0.35 9.69e-11 Neuroticism; CRC cis rs11676348 0.967 rs4672873 chr2:219005210 A/G cg00012203 chr2:219082015 ARPC2 -0.38 -5.81 -0.3 1.49e-8 Ulcerative colitis; CRC cis rs9323205 0.953 rs11623710 chr14:51694261 C/T cg23942311 chr14:51606299 NA -0.54 -6.69 -0.35 9.5e-11 Cancer; CRC cis rs7927771 0.524 rs10742824 chr11:47864842 C/T cg20307385 chr11:47447363 PSMC3 0.45 6.62 0.34 1.48e-10 Subjective well-being; CRC cis rs9399135 0.636 rs4646871 chr6:135265617 A/G cg22676075 chr6:135203613 NA -0.44 -6.83 -0.35 4.19e-11 Red blood cell count; CRC cis rs8078723 0.738 rs8066582 chr17:38146929 A/G cg17344932 chr17:38183730 MED24;SNORD124 0.48 7.98 0.4 2.45e-14 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); CRC cis rs17331151 0.573 rs11718060 chr3:52875546 G/A cg06204229 chr3:52865917 ITIH4 0.56 7.63 0.39 2.48e-13 Immune reponse to smallpox (secreted IL-2); CRC cis rs1868673 1.000 rs6810143 chr3:150174510 A/T cg04908077 chr3:150187338 NA 0.33 5.77 0.3 1.82e-8 Waist circumference; CRC cis rs6088580 0.634 rs6120650 chr20:33039973 G/A cg08999081 chr20:33150536 PIGU 0.61 11.56 0.54 3.73e-26 Glomerular filtration rate (creatinine); CRC cis rs172166 0.694 rs9295760 chr6:28147385 G/A cg12172441 chr6:28176163 NA 0.55 7.48 0.38 6.69e-13 Cardiac Troponin-T levels; CRC cis rs4601821 0.635 rs12282356 chr11:113208382 A/G cg14159747 chr11:113255604 NA 0.43 8.04 0.41 1.62e-14 Alcoholic chronic pancreatitis; CRC trans rs1814175 0.817 rs10769598 chr11:49669326 C/G cg21153622 chr11:89784906 NA -0.38 -6.15 -0.32 2.29e-9 Height; CRC cis rs6484504 0.576 rs208083 chr11:31196880 C/T cg14844989 chr11:31128820 NA -0.32 -5.79 -0.3 1.69e-8 Red blood cell count; CRC cis rs1552244 1.000 rs35741213 chr3:10087661 A/G cg13047869 chr3:10149882 C3orf24 0.57 7.8 0.4 8.27e-14 Alzheimer's disease; CRC cis rs12995491 0.731 rs17435433 chr2:88509616 A/G cg18490616 chr2:88469792 THNSL2 -0.39 -5.75 -0.3 2.04e-8 Response to metformin (IC50); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg08286599 chr2:191208694 INPP1 0.51 7.38 0.38 1.27e-12 Response to antipsychotic treatment; CRC cis rs2735413 0.918 rs34094825 chr16:78081392 G/C cg04733911 chr16:78082701 NA -0.44 -7.37 -0.38 1.38e-12 Systolic blood pressure (alcohol consumption interaction); CRC cis rs11148252 0.774 rs56033750 chr13:52747278 A/C cg12458913 chr13:53173898 NA 0.56 8.95 0.44 2.6e-17 Lewy body disease; CRC cis rs11792861 0.816 rs11790105 chr9:111731785 T/C cg05043794 chr9:111880884 C9orf5 -0.34 -6.06 -0.32 3.76e-9 Menarche (age at onset); CRC cis rs6502050 0.814 rs62079997 chr17:80076888 C/T cg25804541 chr17:80189381 SLC16A3 0.32 6.13 0.32 2.51e-9 Life satisfaction; CRC cis rs6570726 0.935 rs392014 chr6:145843691 A/C cg23711669 chr6:146136114 FBXO30 0.68 12.13 0.56 3.13e-28 Lobe attachment (rater-scored or self-reported); CRC cis rs2239547 0.522 rs9865094 chr3:52985319 G/C cg11645453 chr3:52864694 ITIH4 -0.51 -9.67 -0.47 1.21e-19 Schizophrenia; CRC cis rs7044106 0.791 rs10984997 chr9:123481206 T/A cg09419670 chr9:123605666 PSMD5;LOC253039 0.69 10.53 0.5 1.53e-22 Hip circumference adjusted for BMI; CRC cis rs7811142 1.000 rs11771241 chr7:99994785 G/A cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.75 9.98 0.48 1.12e-20 Platelet count; CRC cis rs12325245 0.536 rs17821549 chr16:58554780 C/T cg02549819 chr16:58548995 SETD6 1.23 7.95 0.4 2.98e-14 Schizophrenia; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg05796909 chr17:7465070 SENP3 0.38 6.0 0.31 5.14e-9 Liver disease severity in Alagille syndrome; CRC cis rs4713118 0.662 rs175954 chr6:28011585 A/G cg02683197 chr6:28174875 NA 0.71 9.48 0.46 5.15e-19 Parkinson's disease; CRC cis rs9322193 0.923 rs14314 chr6:150141531 A/C cg13206674 chr6:150067644 NUP43 0.58 8.25 0.41 3.79e-15 Lung cancer; CRC cis rs4862750 0.872 rs6553029 chr4:187876470 G/T cg11301795 chr4:187892539 NA 0.83 17.94 0.7 1.18e-50 Lobe attachment (rater-scored or self-reported); CRC cis rs10504229 0.683 rs61201557 chr8:58138370 T/C cg02290350 chr8:58132656 NA -0.58 -8.16 -0.41 7.29e-15 Developmental language disorder (linguistic errors); CRC cis rs679087 0.640 rs79708380 chr12:29909457 G/A cg14258853 chr12:29935411 TMTC1 -0.39 -6.34 -0.33 7.51e-10 Schizophrenia; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg13703666 chr11:66115419 B3GNT1 0.51 6.7 0.35 8.85e-11 Thyroid stimulating hormone; CRC cis rs875971 0.789 rs10260426 chr7:65736042 G/T cg11764359 chr7:65958608 NA -0.58 -8.61 -0.43 3.09e-16 Aortic root size; CRC trans rs208520 0.560 rs2351880 chr6:66863707 G/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.05 -14.79 -0.63 2.62e-38 Exhaled nitric oxide output; CRC cis rs2576037 0.901 rs2060416 chr18:44576240 G/C cg20875182 chr18:44561130 TCEB3B;KATNAL2 -0.49 -7.94 -0.4 3.27e-14 Personality dimensions; CRC cis rs9322193 0.962 rs1889473 chr6:150146621 C/G cg13206674 chr6:150067644 NUP43 0.53 7.5 0.38 6.09e-13 Lung cancer; CRC cis rs7584330 0.780 rs937395 chr2:238378749 T/C cg16989719 chr2:238392110 NA -0.45 -8.98 -0.44 2.15e-17 Prostate cancer; CRC cis rs2019137 0.560 rs10175462 chr2:113988492 G/A cg09704166 chr2:114031854 PAX8;LOC440839 -0.36 -6.8 -0.35 4.87e-11 Lymphocyte counts; CRC cis rs1008375 1.000 rs4698649 chr4:17692782 A/G cg16339924 chr4:17578868 LAP3 0.47 6.31 0.33 8.96e-10 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs853679 0.517 rs9295758 chr6:28120663 C/G cg12273811 chr6:28175739 NA 0.73 9.16 0.45 5.8e-18 Depression; CRC trans rs1455244 0.700 rs7229302 chr18:11508904 G/T cg24879395 chr17:48785255 ANKRD40 0.4 6.03 0.32 4.45e-9 Schizophrenia; CRC cis rs9309473 0.687 rs11126399 chr2:73613341 G/A cg20560298 chr2:73613845 ALMS1 -0.56 -7.11 -0.37 7.06e-12 Metabolite levels; CRC cis rs7937682 0.883 rs1784775 chr11:111472460 T/C cg19812747 chr11:111475976 SIK2 -0.58 -9.91 -0.48 2e-20 Primary sclerosing cholangitis; CRC cis rs847577 0.609 rs11763970 chr7:97817321 A/G cg24562669 chr7:97807699 LMTK2 0.76 16.8 0.68 3.73e-46 Breast cancer; CRC cis rs4332037 0.754 rs62436669 chr7:1926636 G/A cg23422044 chr7:1970798 MAD1L1 -0.62 -7.81 -0.4 7.53e-14 Bipolar disorder; CRC trans rs2797160 0.967 rs1954360 chr6:126001064 A/G cg05039488 chr6:79577232 IRAK1BP1 -0.5 -7.47 -0.38 7.12e-13 Endometrial cancer; CRC cis rs4332037 0.901 rs7791899 chr7:1935988 T/C cg24505167 chr7:1915268 MAD1L1 -0.42 -5.88 -0.31 1e-8 Bipolar disorder; CRC cis rs1707322 1.000 rs4134387 chr1:46395158 A/T cg03146154 chr1:46216737 IPP 0.58 8.14 0.41 8.5e-15 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs6570726 0.935 rs422540 chr6:145837815 G/T cg05347473 chr6:146136440 FBXO30 0.37 6.0 0.31 5.27e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs2204008 0.694 rs10880262 chr12:38328696 C/T cg26384229 chr12:38710491 ALG10B 0.54 7.64 0.39 2.35e-13 Bladder cancer; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg13690588 chr1:28415118 EYA3 -0.39 -6.41 -0.33 4.97e-10 Myopia (pathological); CRC cis rs4891159 0.757 rs11665518 chr18:74147054 C/T cg24786174 chr18:74118243 ZNF516 -0.85 -14.7 -0.63 5.81e-38 Longevity; CRC cis rs1046896 0.739 rs28459016 chr17:80741194 G/A cg17346650 chr17:80929145 B3GNTL1 0.39 5.76 0.3 1.95e-8 Glycated hemoglobin levels; CRC cis rs10504229 0.728 rs72650858 chr8:58152832 G/A cg02725872 chr8:58115012 NA -0.57 -9.07 -0.45 1.09e-17 Developmental language disorder (linguistic errors); CRC cis rs1862618 0.802 rs42769 chr5:56144152 G/A cg20203395 chr5:56204925 C5orf35 -0.69 -8.26 -0.41 3.72e-15 Initial pursuit acceleration; CRC cis rs477895 1.000 rs7939107 chr11:64034773 C/T cg18225595 chr11:63971243 STIP1 0.58 6.62 0.34 1.46e-10 Mean platelet volume; CRC cis rs72945132 0.882 rs59398290 chr11:70134819 G/A cg00319359 chr11:70116639 PPFIA1 0.67 7.4 0.38 1.13e-12 Coronary artery disease; CRC cis rs7208859 0.623 rs7503335 chr17:29073962 G/A cg01831904 chr17:28903510 LRRC37B2 -0.63 -6.46 -0.34 3.66e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg21587861 chr12:32260103 BICD1 0.41 6.01 0.31 4.95e-9 Response to antipsychotic treatment; CRC cis rs1153858 1.000 rs4271549 chr15:45652730 G/A cg14582100 chr15:45693742 SPATA5L1 0.29 6.14 0.32 2.41e-9 Homoarginine levels; CRC cis rs9311474 0.508 rs2878628 chr3:52584715 C/T cg15147215 chr3:52552868 STAB1 0.64 11.0 0.52 3.6e-24 Electroencephalogram traits; CRC cis rs3126085 0.935 rs10888468 chr1:152181539 C/T cg09127314 chr1:152161683 NA 0.53 6.69 0.35 9.52e-11 Atopic dermatitis; CRC cis rs727505 1.000 rs77718560 chr7:124514544 T/A cg23710748 chr7:124431027 NA -0.8 -14.17 -0.62 6.58e-36 Lewy body disease; CRC cis rs911119 1.000 rs73318135 chr20:23618571 T/G cg16589663 chr20:23618590 CST3 0.62 7.98 0.4 2.41e-14 Chronic kidney disease; CRC cis rs1790761 0.967 rs1808279 chr11:67211569 T/C cg17375396 chr11:67202808 RPS6KB2 0.34 5.83 0.31 1.32e-8 Mean corpuscular volume; CRC cis rs763121 0.853 rs2413544 chr22:39059404 A/C cg06022373 chr22:39101656 GTPBP1 0.79 12.53 0.57 1.01e-29 Menopause (age at onset); CRC cis rs916888 0.687 rs199456 chr17:44797919 C/T cg01570182 chr17:44337453 NA 1.25 14.37 0.62 1.14e-36 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs10540 1.000 rs12417570 chr11:462684 C/T cg03352830 chr11:487213 PTDSS2 0.67 7.15 0.37 5.58e-12 Body mass index; CRC cis rs7264396 0.676 rs6060729 chr20:34557004 G/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.61 -9.83 -0.48 3.75e-20 Total cholesterol levels; CRC cis rs2274273 0.870 rs6573009 chr14:55682324 A/C cg23234261 chr14:55582407 NA -0.3 -5.93 -0.31 7.74e-9 Protein biomarker; CRC cis rs1670533 1.000 rs6852850 chr4:1052857 C/G cg27284194 chr4:1044797 NA 0.5 6.2 0.32 1.66e-9 Recombination rate (females); CRC cis rs6459788 0.720 rs11768765 chr7:157253133 C/T cg06271696 chr7:157225062 NA -0.57 -9.69 -0.47 1.07e-19 Epstein-Barr virus copy number in lymphoblastoid cell lines; CRC cis rs34311866 0.808 rs62294491 chr4:969111 C/T cg07828340 chr4:882639 GAK 1.09 10.3 0.49 9.83e-22 Parkinson's disease; CRC cis rs514406 0.861 rs551435 chr1:53260537 G/T cg08859206 chr1:53392774 SCP2 0.45 6.96 0.36 1.89e-11 Monocyte count; CRC cis rs524023 0.957 rs552307 chr11:64357539 G/A cg14139581 chr11:64358342 SLC22A12 0.38 5.99 0.31 5.4e-9 Urate levels in obese individuals; CRC trans rs10982213 0.830 rs2274163 chr9:117188714 C/T cg02284587 chr1:64971218 CACHD1 -0.41 -6.02 -0.31 4.54e-9 Interleukin-6 levels; CRC cis rs7493 0.853 rs2299266 chr7:95049073 A/G cg04155289 chr7:94953770 PON1 -0.62 -7.69 -0.39 1.77e-13 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs4478137 0.931 rs4057797 chr4:164245053 T/A cg06758707 chr4:164254230 NPY1R 0.38 5.87 0.31 1.05e-8 Subjective well-being (multi-trait analysis);Subjective well-being; CRC cis rs936229 0.511 rs12591513 chr15:75102714 G/A cg14664628 chr15:75095509 CSK -0.72 -11.98 -0.55 1.11e-27 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); CRC cis rs17539620 0.506 rs62432749 chr6:154839219 G/A cg20019720 chr6:154832845 CNKSR3 0.5 8.06 0.41 1.44e-14 Lipoprotein (a) levels; CRC cis rs2000999 0.725 rs12924886 chr16:72075593 A/T cg01557791 chr16:72042693 DHODH -0.58 -5.83 -0.31 1.35e-8 Total cholesterol levels;Cholesterol, total;Blood protein levels;LDL cholesterol levels;Haptoglobin levels;LDL cholesterol; CRC cis rs853679 0.517 rs1853097 chr6:28058635 A/G cg02683197 chr6:28174875 NA 0.82 10.03 0.48 7.9e-21 Depression; CRC cis rs2153535 0.601 rs2327059 chr6:8447071 A/G cg21535247 chr6:8435926 SLC35B3 0.5 7.53 0.38 4.92e-13 Motion sickness; CRC cis rs9814567 0.806 rs11927540 chr3:134319455 C/T cg06541857 chr3:134203789 ANAPC13;CEP63 -0.37 -5.8 -0.3 1.58e-8 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs7726839 0.540 rs72703083 chr5:595365 C/T cg09021430 chr5:549028 NA -0.72 -8.29 -0.42 2.99e-15 Obesity-related traits; CRC cis rs12594515 0.967 rs12595138 chr15:45986108 G/C cg06207120 chr15:45996521 NA 0.32 7.66 0.39 2.08e-13 Waist circumference;Weight; CRC cis rs67478160 0.608 rs4906368 chr14:104242397 A/C cg08213375 chr14:104286397 PPP1R13B 0.58 12.0 0.55 9.44e-28 Schizophrenia; CRC cis rs7309 0.870 rs2358016 chr2:162007430 C/G cg22496339 chr2:162101262 NA -0.8 -13.65 -0.6 6.59e-34 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Educational attainment; CRC cis rs4363385 0.647 rs7548977 chr1:152987365 T/G cg25856811 chr1:152973957 SPRR3 -0.22 -6.01 -0.31 4.96e-9 Inflammatory skin disease; CRC cis rs73206853 0.841 rs73191828 chr12:110946121 G/A cg12870014 chr12:110450643 ANKRD13A 0.73 7.86 0.4 5.56e-14 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg11530914 chr16:67281528 FHOD1;SLC9A5 -0.54 -6.61 -0.34 1.58e-10 Diisocyanate-induced asthma; CRC cis rs2777491 0.915 rs7178634 chr15:41634587 A/G cg18705301 chr15:41695430 NDUFAF1 -0.69 -11.43 -0.53 1.08e-25 Ulcerative colitis; CRC cis rs457287 0.554 rs456978 chr9:4833960 A/G cg14182974 chr9:4791918 RCL1 0.37 5.7 0.3 2.6e-8 Platelet count; CRC cis rs59104589 0.617 rs7568 chr2:242291743 A/G cg19488206 chr2:242435732 STK25 0.47 6.65 0.34 1.19e-10 Fibrinogen levels; CRC cis rs6952808 0.792 rs12536261 chr7:1953571 G/A cg04267008 chr7:1944627 MAD1L1 -0.84 -12.83 -0.58 7.85e-31 Bipolar disorder and schizophrenia; CRC cis rs4728302 0.838 rs7798804 chr7:133584085 C/T cg10665199 chr7:133106180 EXOC4 0.38 5.8 0.3 1.54e-8 Intelligence;Intelligence (multi-trait analysis); CRC cis rs11122272 0.668 rs2790874 chr1:231537988 A/G cg06096015 chr1:231504339 EGLN1 0.41 6.18 0.32 1.9e-9 Hemoglobin concentration; CRC cis rs8177253 1.000 rs8177240 chr3:133477701 T/G cg01448562 chr3:133502909 NA -0.52 -8.72 -0.43 1.44e-16 Iron status biomarkers; CRC cis rs6952808 0.608 rs58120505 chr7:2029867 T/C cg14004847 chr7:1930337 MAD1L1 -0.42 -5.79 -0.3 1.64e-8 Bipolar disorder and schizophrenia; CRC cis rs1215050 0.791 rs165239 chr4:98682549 C/T cg05340658 chr4:99064831 C4orf37 0.47 7.01 0.36 1.4e-11 Waist-to-hip ratio adjusted for body mass index; CRC cis rs6088590 1.000 rs1998028 chr20:33344595 A/T cg08999081 chr20:33150536 PIGU 0.51 8.78 0.44 9.35e-17 Coronary artery disease; CRC cis rs748404 0.697 rs572959 chr15:43550502 T/C cg02155558 chr15:43621948 ADAL;LCMT2 0.44 6.55 0.34 2.21e-10 Lung cancer; CRC cis rs853679 0.517 rs9380062 chr6:28137569 G/A cg12963246 chr6:28129442 ZNF389 0.49 5.7 0.3 2.71e-8 Depression; CRC trans rs58688157 0.705 rs12419720 chr11:598205 C/G cg19188899 chr13:112838565 NA -0.41 -6.4 -0.33 5.35e-10 Systemic lupus erythematosus; CRC cis rs9549328 0.700 rs4907570 chr13:113617651 T/C cg24588162 chr13:113633484 MCF2L 0.36 6.51 0.34 2.89e-10 Systolic blood pressure; CRC cis rs4243830 0.850 rs4908915 chr1:6601607 T/C cg22792644 chr1:6614718 TAS1R1;NOL9 -0.81 -9.22 -0.45 3.64e-18 Body mass index; CRC cis rs7923609 0.967 rs7915779 chr10:65244244 G/C cg08743896 chr10:65200160 JMJD1C -0.42 -6.06 -0.32 3.73e-9 Educational attainment;Liver enzyme levels (alkaline phosphatase); CRC cis rs11190604 1.000 rs7088512 chr10:102303498 G/T cg16342193 chr10:102329863 NA -0.33 -5.69 -0.3 2.85e-8 Palmitoleic acid (16:1n-7) levels; CRC cis rs9911578 0.835 rs9788975 chr17:56460800 G/A cg12560992 chr17:57184187 TRIM37 -0.83 -14.01 -0.61 2.8e-35 Intelligence (multi-trait analysis); CRC cis rs6502050 0.835 rs8065210 chr17:80090960 G/A cg25804541 chr17:80189381 SLC16A3 -0.3 -5.74 -0.3 2.19e-8 Life satisfaction; CRC cis rs7474896 0.537 rs2749588 chr10:38269457 C/G cg25427524 chr10:38739819 LOC399744 -0.56 -7.04 -0.36 1.12e-11 Obesity (extreme); CRC cis rs2952156 0.959 rs2941504 chr17:37830900 A/G cg00129232 chr17:37814104 STARD3 -0.68 -11.31 -0.53 2.8e-25 Asthma; CRC cis rs7666738 0.924 rs11097592 chr4:98927532 C/T cg05340658 chr4:99064831 C4orf37 0.5 6.94 0.36 2.1e-11 Colonoscopy-negative controls vs population controls; CRC cis rs8177253 0.829 rs9813689 chr3:133514822 C/T cg12373951 chr3:133503437 NA 0.26 6.51 0.34 2.85e-10 Iron status biomarkers; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg00356511 chr17:35716273 ACACA 0.39 6.25 0.33 1.24e-9 Liver disease severity in Alagille syndrome; CRC cis rs2739330 0.760 rs5751760 chr22:24243573 G/A cg09033563 chr22:24373618 LOC391322 -0.41 -5.77 -0.3 1.84e-8 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs4290604 0.665 rs6761002 chr2:238038873 T/C cg23555395 chr2:238036564 NA -0.65 -6.64 -0.34 1.3100000000000001e-10 Asthma; CRC cis rs3736594 0.527 rs62141279 chr2:27771415 C/T cg27432699 chr2:27873401 GPN1 0.64 8.18 0.41 6.34e-15 Fasting blood glucose;Fasting blood glucose (BMI interaction); CRC cis rs9463078 0.669 rs17288334 chr6:45351391 A/G cg25276700 chr6:44698697 NA 0.26 6.04 0.32 4.25e-9 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; CRC cis rs6912958 0.712 rs2754262 chr6:88405585 A/G cg08069147 chr6:88032118 GJB7;C6orf162 -0.53 -7.9 -0.4 4.09e-14 Monocyte percentage of white cells; CRC cis rs1997103 1.000 rs9642580 chr7:55400359 G/A cg17469321 chr7:55412551 NA 0.72 11.23 0.53 5.51e-25 QRS interval (sulfonylurea treatment interaction); CRC cis rs887797 0.557 rs9900353 chr17:64575492 A/G cg27019712 chr17:64599478 PRKCA 0.38 5.74 0.3 2.14e-8 Possible neuropathic pain in post total joint replacement surgery for osteoarthritis; CRC trans rs13046373 0.905 rs4816372 chr21:32077414 A/T cg08445226 chr3:99536904 C3orf26;MIR548G -0.42 -6.1 -0.32 2.92e-9 HDL cholesterol; CRC cis rs7584330 0.740 rs7586312 chr2:238439389 G/A cg16989719 chr2:238392110 NA -0.35 -6.25 -0.33 1.24e-9 Prostate cancer; CRC cis rs6952808 0.609 rs12699449 chr7:1951227 G/C cg00106254 chr7:1943704 MAD1L1 -0.37 -5.8 -0.3 1.57e-8 Bipolar disorder and schizophrenia; CRC cis rs7590720 0.851 rs13006614 chr2:216876204 C/T cg12620499 chr2:216877984 MREG 0.87 15.77 0.66 3.91e-42 Alcohol dependence; CRC trans rs629535 0.821 rs497398 chr8:70037434 A/T cg21567404 chr3:27674614 NA 0.95 16.08 0.66 2.35e-43 Dupuytren's disease; CRC cis rs4862750 0.914 rs10027250 chr4:187873460 T/C cg07414643 chr4:187882934 NA 0.36 6.21 0.32 1.63e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs9649213 0.574 rs7802541 chr7:97933855 C/A cg21770322 chr7:97807741 LMTK2 0.52 8.44 0.42 9.92e-16 Prostate cancer (SNP x SNP interaction); CRC trans rs73162807 0.655 rs17436397 chr3:146443282 T/C cg26896787 chr1:228603707 TRIM17 -0.59 -5.99 -0.31 5.61e-9 Platelet-derived growth factor BB levels; CRC cis rs801193 0.591 rs721717 chr7:66130292 G/T cg18876405 chr7:65276391 NA -0.5 -8.05 -0.41 1.5e-14 Aortic root size; CRC cis rs6912958 0.935 rs6454629 chr6:88165515 A/G cg08069147 chr6:88032118 GJB7;C6orf162 -0.63 -9.55 -0.47 3.07e-19 Monocyte percentage of white cells; CRC cis rs9902453 0.967 rs55744550 chr17:28475729 G/A cg26525008 chr17:28256777 EFCAB5;SSH2 0.58 9.15 0.45 6.04e-18 Coffee consumption (cups per day); CRC cis rs11955398 0.521 rs6449489 chr5:60026236 A/G cg02684056 chr5:59996105 DEPDC1B -0.4 -5.62 -0.3 3.98e-8 Intelligence (multi-trait analysis); CRC cis rs873946 0.586 rs36084869 chr10:134566069 G/A cg18305652 chr10:134549665 INPP5A 0.49 6.26 0.33 1.23e-9 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CRC trans rs79976124 0.800 rs6918860 chr6:66637741 G/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.72 9.09 0.45 9.43e-18 Type 2 diabetes; CRC cis rs7917772 0.503 rs7915589 chr10:104299264 G/A cg04362960 chr10:104952993 NT5C2 -0.41 -5.79 -0.3 1.62e-8 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC cis rs449789 0.524 rs1553480 chr6:159742596 T/C cg14500486 chr6:159655392 FNDC1 -0.49 -7.53 -0.38 4.81e-13 Pulse pressure; CRC cis rs796364 0.760 rs56225698 chr2:200910653 A/C cg25936922 chr2:200820526 C2orf60;C2orf47 -0.7 -6.57 -0.34 2.02e-10 Schizophrenia; CRC cis rs7089973 0.604 rs17095662 chr10:116596071 A/C cg23260525 chr10:116636907 FAM160B1 0.37 8.77 0.44 9.59e-17 Bipolar disorder or attention deficit hyperactivity disorder; CRC trans rs11098499 0.954 rs12508504 chr4:120410607 A/C cg25214090 chr10:38739885 LOC399744 0.64 10.61 0.5 8.1e-23 Corneal astigmatism; CRC cis rs4780401 0.609 rs55934118 chr16:11820003 G/C cg01061890 chr16:11836724 TXNDC11 -0.6 -8.98 -0.44 2.09e-17 Rheumatoid arthritis; CRC cis rs6952808 0.792 rs11771973 chr7:1950440 C/G cg21782813 chr7:2030301 MAD1L1 0.45 7.69 0.39 1.67e-13 Bipolar disorder and schizophrenia; CRC cis rs798554 0.679 rs1636250 chr7:2884433 T/C cg19346786 chr7:2764209 NA -0.37 -6.21 -0.32 1.64e-9 Height; CRC cis rs889398 0.835 rs12925429 chr16:69801539 G/A cg00738113 chr16:70207722 CLEC18C 0.37 6.24 0.33 1.36e-9 Body mass index; CRC cis rs28386778 0.897 rs2665797 chr17:61922485 C/G cg06601766 chr17:61851465 DDX42;CCDC47 -0.41 -5.64 -0.3 3.6e-8 Prudent dietary pattern; CRC cis rs9826463 0.757 rs73240314 chr3:142255090 T/C cg20824294 chr3:142316082 PLS1 0.41 6.96 0.36 1.85e-11 QRS duration in Tripanosoma cruzi seropositivity; CRC cis rs7647973 1.000 rs11720542 chr3:49357427 A/G cg07636037 chr3:49044803 WDR6 0.61 7.34 0.38 1.65e-12 Menarche (age at onset); CRC cis rs3764563 0.735 rs62106282 chr19:15727124 T/C cg20725493 chr19:15740067 CYP4F8 -0.67 -6.38 -0.33 5.84e-10 Inflammatory biomarkers; CRC cis rs1552244 0.938 rs67667957 chr3:10167264 G/C cg08888203 chr3:10149979 C3orf24 0.7 9.58 0.47 2.4e-19 Alzheimer's disease; CRC trans rs1864585 0.520 rs17776427 chr8:10672972 G/T cg26278703 chr11:58910052 FAM111A 0.54 6.47 0.34 3.63e-10 Neutrophil percentage of white cells;Lymphocyte percentage of white cells; CRC trans rs596169 0.649 rs3885898 chr1:219126770 T/C cg09853702 chr12:47665230 NA 0.77 6.4 0.33 5.4e-10 Intraocular pressure; CRC cis rs10992471 0.580 rs1535756 chr9:95202032 G/A cg14631576 chr9:95140430 CENPP -0.4 -7.13 -0.37 6.48e-12 Visceral adipose tissue/subcutaneous adipose tissue ratio; CRC cis rs853679 0.517 rs56310871 chr6:28044482 A/G cg15845792 chr6:28175446 NA 0.97 13.03 0.58 1.43e-31 Depression; CRC trans rs561341 1.000 rs117029332 chr17:30266085 C/G cg20587970 chr11:113659929 NA -1.43 -20.28 -0.75 6.91e-60 Hip circumference adjusted for BMI; CRC cis rs11608355 0.545 rs61941585 chr12:109905222 C/T cg05360138 chr12:110035743 NA 0.75 7.63 0.39 2.49e-13 Neuroticism; CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg05329982 chr11:62359210 TUT1 -0.52 -6.22 -0.32 1.48e-9 Diisocyanate-induced asthma; CRC cis rs10450586 0.863 rs7102043 chr11:27305839 C/T cg10370305 chr11:27303972 NA 0.37 6.02 0.31 4.69e-9 Total body bone mineral density; CRC cis rs11711311 0.955 rs2124105 chr3:113406003 G/A cg15478005 chr3:113465772 ATP6V1A;NAA50 0.46 6.2 0.32 1.73e-9 IgG glycosylation; CRC cis rs11122272 0.735 rs2491416 chr1:231547335 T/C cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX 0.56 8.41 0.42 1.27e-15 Hemoglobin concentration; CRC cis rs11123170 0.569 rs1049137 chr2:113975110 A/G cg12889195 chr2:113992843 PAX8;LOC440839;LOC654433 0.5 5.96 0.31 6.38e-9 Renal function-related traits (BUN); CRC cis rs13217239 0.646 rs10946897 chr6:26995251 A/C cg12292205 chr6:26970375 C6orf41 0.56 9.34 0.46 1.49e-18 Schizophrenia; CRC cis rs2739330 0.760 rs5751760 chr22:24243573 G/A cg10819733 chr22:24237672 NA -0.37 -6.35 -0.33 7.23e-10 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs208515 0.556 rs12206707 chr6:66697182 A/G cg07460842 chr6:66804631 NA 0.98 12.45 0.57 2.05e-29 Exhaled nitric oxide levels; CRC cis rs8141529 0.748 rs1318025 chr22:29283757 C/T cg02153584 chr22:29168773 CCDC117 0.46 6.64 0.34 1.29e-10 Lymphocyte counts; CRC cis rs1448094 0.545 rs11117077 chr12:86277317 A/G cg18827107 chr12:86230957 RASSF9 -0.45 -7.24 -0.37 3.29e-12 Major depressive disorder; CRC cis rs10982256 0.622 rs4979410 chr9:117239877 C/T cg13636371 chr9:117264095 DFNB31 0.33 6.13 0.32 2.46e-9 Bipolar disorder; CRC cis rs7618915 1.000 rs7618915 chr3:52279594 G/A cg15147215 chr3:52552868 STAB1 -0.53 -7.69 -0.39 1.7e-13 Bipolar disorder; CRC cis rs992157 0.835 rs12987180 chr2:219144089 G/A cg00012203 chr2:219082015 ARPC2 -0.47 -7.16 -0.37 5.15e-12 Colorectal cancer; CRC trans rs7819412 0.595 rs2409712 chr8:10986837 A/C cg16141378 chr3:129829833 LOC729375 0.44 6.59 0.34 1.8e-10 Triglycerides; CRC cis rs13144136 0.647 rs12509884 chr4:10654043 C/T cg10242279 chr4:10666415 CLNK -0.37 -6.39 -0.33 5.8e-10 Resistance to antihypertensive treatment in hypertension; CRC cis rs2243480 1.000 rs13237037 chr7:65997882 T/C cg12463550 chr7:65579703 CRCP 0.68 6.13 0.32 2.58e-9 Diabetic kidney disease; CRC cis rs1534166 0.647 rs7355929 chr3:133514190 C/T cg01448562 chr3:133502909 NA 0.45 6.7 0.35 9.07e-11 Alcohol consumption (transferrin glycosylation); CRC cis rs10791323 0.569 rs2156679 chr11:133742304 C/T cg15485101 chr11:133734466 NA 0.43 8.1 0.41 1.06e-14 Childhood ear infection; CRC cis rs9322193 0.923 rs9322214 chr6:150025122 C/T cg00933542 chr6:150070202 PCMT1 0.32 6.45 0.33 4.11e-10 Lung cancer; CRC cis rs7044106 0.762 rs1324473 chr9:123404610 C/T cg14255062 chr9:123606675 PSMD5;LOC253039 -0.45 -6.98 -0.36 1.63e-11 Hip circumference adjusted for BMI; CRC cis rs3859192 0.599 rs34933056 chr17:38162983 G/A cg17344932 chr17:38183730 MED24;SNORD124 0.86 16.5 0.67 5.46e-45 White blood cell count; CRC cis rs2839186 0.609 rs2839189 chr21:47694357 C/T cg26721908 chr21:47610096 LSS 0.47 6.84 0.35 3.93e-11 Testicular germ cell tumor; CRC cis rs1729951 0.575 rs747843 chr3:136703130 G/C cg21827317 chr3:136751795 NA 0.36 5.85 0.31 1.19e-8 Neuroticism; CRC cis rs2745959 0.611 rs2785644 chr1:208059691 C/T cg09788693 chr1:208063733 CD34 0.43 5.8 0.3 1.55e-8 Resting heart rate; CRC cis rs854572 0.870 rs757158 chr7:94955528 C/T cg04871131 chr7:94954202 PON1 -0.63 -9.63 -0.47 1.64e-19 Paraoxonase activity; CRC cis rs875971 0.862 rs10278014 chr7:66051264 C/T cg12463550 chr7:65579703 CRCP -0.48 -6.44 -0.33 4.22e-10 Aortic root size; CRC cis rs11628318 0.803 rs2277468 chr14:103024080 A/G cg12046867 chr14:103022105 NA -0.79 -10.71 -0.51 3.73e-23 Platelet count; CRC cis rs7781266 0.842 rs1364364 chr7:133244493 C/T cg03336402 chr7:133662267 EXOC4 0.49 5.78 0.3 1.74e-8 Educational attainment (college completion); CRC cis rs6598955 0.724 rs3924934 chr1:26644079 A/G cg04990556 chr1:26633338 UBXN11 -0.74 -11.88 -0.55 2.53e-27 Obesity-related traits; CRC cis rs1832871 0.672 rs111782080 chr6:158765385 G/A cg07165851 chr6:158734300 TULP4 0.62 7.81 0.4 7.61e-14 Height; CRC cis rs11971779 0.523 rs10234578 chr7:139037988 T/C cg07862535 chr7:139043722 LUC7L2 0.57 7.33 0.37 1.8e-12 Diisocyanate-induced asthma; CRC cis rs9914988 0.943 rs9890377 chr17:27111111 A/G cg20469991 chr17:27169893 C17orf63 -0.6 -7.27 -0.37 2.59e-12 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs4665809 0.525 rs4665324 chr2:26447147 A/C cg27170947 chr2:26402098 FAM59B -0.6 -7.82 -0.4 7.45e-14 Gut microbiome composition (summer); CRC cis rs6502050 0.835 rs3935129 chr17:80113381 G/C cg02741985 chr17:80059408 CCDC57 0.43 7.15 0.37 5.66e-12 Life satisfaction; CRC cis rs933688 1.000 rs6862125 chr5:90724598 T/C cg26981201 chr5:90679533 LOC100129716;ARRDC3 1.06 17.32 0.69 3.31e-48 Smoking behavior; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg06157335 chr1:53164003 C1orf163 0.51 6.43 0.33 4.62e-10 Thyroid stimulating hormone; CRC cis rs514406 0.505 rs431427 chr1:53179094 C/A cg25767906 chr1:53392781 SCP2 -0.39 -6.11 -0.32 2.86e-9 Monocyte count; CRC cis rs8180040 0.620 rs9844122 chr3:47108330 C/T cg27129171 chr3:47204927 SETD2 0.72 11.33 0.53 2.45e-25 Colorectal cancer; CRC cis rs477692 0.569 rs10764882 chr10:131306496 C/G cg05714579 chr10:131428358 MGMT 0.53 7.71 0.39 1.47e-13 Response to temozolomide; CRC cis rs2576037 0.763 rs2060418 chr18:44576535 A/C cg19077165 chr18:44547161 KATNAL2 0.44 6.75 0.35 6.6e-11 Personality dimensions; CRC trans rs6076960 0.684 rs3844461 chr20:6253115 G/A cg21095983 chr6:86352623 SYNCRIP 0.58 8.3 0.42 2.82e-15 Smooth-surface caries; CRC cis rs2976388 0.556 rs4736321 chr8:143822194 C/T cg24634471 chr8:143751801 JRK -0.5 -6.77 -0.35 5.9e-11 Urinary tract infection frequency; CRC cis rs6570726 0.738 rs7746330 chr6:145899257 A/C cg23711669 chr6:146136114 FBXO30 0.76 13.22 0.59 2.65e-32 Lobe attachment (rater-scored or self-reported); CRC cis rs4481887 0.732 rs4526647 chr1:248423788 C/G cg00666640 chr1:248458726 OR2T12 0.52 8.84 0.44 5.77e-17 Common traits (Other); CRC cis rs2346160 1.000 rs4709159 chr6:167664918 C/T cg27333441 chr6:167680455 NA -0.38 -6.22 -0.32 1.52e-9 Parental extreme longevity (95 years and older); CRC cis rs2408955 0.541 rs11168428 chr12:48547128 A/G cg21466736 chr12:48725269 NA 0.48 7.33 0.37 1.79e-12 Glycated hemoglobin levels; CRC cis rs3617 0.573 rs9880978 chr3:52923251 C/G cg15147215 chr3:52552868 STAB1 -0.48 -8.17 -0.41 6.75e-15 Red blood cell count;Autism spectrum disorder or schizophrenia; CRC cis rs11098499 0.954 rs4577559 chr4:120404043 T/G cg24375607 chr4:120327624 NA 0.49 7.68 0.39 1.78e-13 Corneal astigmatism; CRC cis rs4665809 1.000 rs11126375 chr2:26344787 G/A cg04944784 chr2:26401820 FAM59B -0.6 -7.67 -0.39 1.98e-13 Gut microbiome composition (summer); CRC cis rs9467773 1.000 rs10946834 chr6:26533664 G/C cg09904177 chr6:26538194 HMGN4 0.86 14.9 0.63 9.92e-39 Intelligence (multi-trait analysis); CRC cis rs172166 0.515 rs2622320 chr6:28115336 T/A cg06470822 chr6:28175283 NA 0.66 10.11 0.49 4.13e-21 Cardiac Troponin-T levels; CRC cis rs1953600 0.837 rs2573352 chr10:81939813 T/C cg00277334 chr10:82204260 NA 0.37 5.93 0.31 7.57e-9 Sarcoidosis; CRC cis rs12449964 0.524 rs4925093 chr17:17568946 G/T cg16928487 chr17:17741425 SREBF1 -0.35 -5.91 -0.31 8.46e-9 Coronary artery disease or ischemic stroke; CRC cis rs3760982 1.000 rs60184524 chr19:44294215 A/G cg11993925 chr19:44307056 LYPD5 0.46 7.58 0.39 3.5e-13 Breast cancer (estrogen-receptor negative);Breast cancer; CRC cis rs7666738 0.830 rs34244876 chr4:99031336 G/A cg17366294 chr4:99064904 C4orf37 0.44 7.48 0.38 6.96e-13 Colonoscopy-negative controls vs population controls; CRC cis rs13191362 1.000 rs71567659 chr6:163001736 G/A cg06582575 chr6:163149167 PACRG;PARK2 0.77 10.7 0.51 3.98e-23 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs59574136 1 rs59574136 chr7:2036460 T/C cg04267008 chr7:1944627 MAD1L1 -0.77 -11.27 -0.53 3.82e-25 Autism spectrum disorder or schizophrenia; CRC cis rs2404602 1.000 rs2120107 chr15:76869789 A/G cg03037974 chr15:76606532 NA 0.54 9.05 0.45 1.25e-17 Blood metabolite levels; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg16977668 chr6:86353909 SYNCRIP 0.42 6.24 0.33 1.32e-9 Intelligence (multi-trait analysis); CRC cis rs7927771 0.832 rs11605672 chr11:47413733 A/G cg20307385 chr11:47447363 PSMC3 -0.62 -8.92 -0.44 3.39e-17 Subjective well-being; CRC cis rs12477438 0.765 rs7605218 chr2:99593080 G/T cg14399236 chr2:99771627 LIPT1;TSGA10 -0.6 -8.2 -0.41 5.56e-15 Chronic sinus infection; CRC cis rs57221529 1.000 rs57221529 chr5:586624 A/G cg09021430 chr5:549028 NA -0.58 -6.31 -0.33 9.16e-10 Lung disease severity in cystic fibrosis; CRC cis rs7584330 0.697 rs1979762 chr2:238436502 T/C cg14458575 chr2:238380390 NA 0.47 8.24 0.41 4.19e-15 Prostate cancer; CRC cis rs7044106 0.537 rs10739573 chr9:123489818 A/G cg09419670 chr9:123605666 PSMD5;LOC253039 0.76 10.43 0.5 3.36e-22 Hip circumference adjusted for BMI; CRC cis rs950776 0.507 rs12912673 chr15:78810216 T/C cg06917634 chr15:78832804 PSMA4 0.67 10.71 0.51 3.55e-23 Sudden cardiac arrest; CRC cis rs4975616 0.869 rs452932 chr5:1330253 T/C cg26373071 chr5:1325741 CLPTM1L 0.55 10.06 0.49 6.09e-21 Lung cancer; CRC cis rs1008375 0.966 rs4698638 chr4:17632988 G/C cg16339924 chr4:17578868 LAP3 0.57 7.71 0.39 1.5e-13 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs4076764 0.958 rs11590567 chr1:163396438 A/G cg24596788 chr1:163392923 NA -0.68 -10.95 -0.52 5.37e-24 Motion sickness; CRC cis rs6860806 0.507 rs272880 chr5:131670178 C/T cg18758796 chr5:131593413 PDLIM4 0.39 6.4 0.33 5.28e-10 Breast cancer; CRC cis rs10744422 0.925 rs2292132 chr12:123332834 T/C cg25930673 chr12:123319894 HIP1R -0.6 -6.32 -0.33 8.36e-10 Schizophrenia; CRC cis rs1322512 1.000 rs9371626 chr6:153008926 G/A cg03415253 chr6:152958462 SYNE1 0.4 6.04 0.32 4.14e-9 Tonometry; CRC cis rs10197940 0.571 rs13393021 chr2:152413258 A/C cg19508488 chr2:152266495 RIF1 0.56 8.26 0.41 3.52e-15 Lung cancer; CRC cis rs733592 0.723 rs10875766 chr12:48593580 G/C cg24011408 chr12:48396354 COL2A1 0.39 5.67 0.3 3.08e-8 Plateletcrit; CRC cis rs6860806 0.661 rs6890009 chr5:131580033 G/T cg22638593 chr5:131593259 PDLIM4 0.39 7.3 0.37 2.13e-12 Breast cancer; CRC cis rs4731207 0.596 rs10231355 chr7:124581218 A/G cg23710748 chr7:124431027 NA -0.38 -6.09 -0.32 3.18e-9 Cutaneous malignant melanoma; CRC cis rs4654899 0.865 rs3856173 chr1:21114833 C/T cg02927042 chr1:21476669 EIF4G3 -0.43 -6.75 -0.35 6.54e-11 Superior frontal gyrus grey matter volume; CRC cis rs9420 0.961 rs71484468 chr11:57632799 G/C cg23127183 chr11:57508653 C11orf31 -0.51 -6.75 -0.35 6.79e-11 Schizophrenia; CRC cis rs2180341 0.824 rs9321076 chr6:127655614 G/A cg27446573 chr6:127587934 RNF146 0.99 14.58 0.63 1.75e-37 Breast cancer; CRC cis rs896854 0.540 rs2011567 chr8:95971920 G/A cg16049864 chr8:95962084 TP53INP1 -0.65 -11.84 -0.55 3.42e-27 Type 2 diabetes; CRC cis rs11123170 0.543 rs12472361 chr2:113980645 C/G cg21482265 chr2:113992762 PAX8;LOC440839;LOC654433 0.51 6.01 0.31 4.96e-9 Renal function-related traits (BUN); CRC cis rs62045849 0.557 rs6500533 chr16:89190065 G/A cg08015503 chr16:89190385 ACSF3 -0.93 -7.4 -0.38 1.18e-12 Red blood cell count; CRC trans rs3942852 0.910 rs10742831 chr11:48119691 G/A cg15704280 chr7:45808275 SEPT13 -0.62 -7.38 -0.38 1.33e-12 Acute lymphoblastic leukemia (childhood); CRC cis rs524281 0.861 rs7941469 chr11:65900152 A/G cg14036092 chr11:66035641 RAB1B 0.45 5.74 0.3 2.17e-8 Electroencephalogram traits; CRC cis rs6504950 0.830 rs17817901 chr17:53038745 A/G cg26251398 chr17:52985966 TOM1L1 0.42 5.62 0.3 4.01e-8 Breast cancer; CRC trans rs9929218 1.000 rs17772363 chr16:68788909 G/T cg04657470 chr2:198365150 HSPE1;HSPD1 -0.95 -14.01 -0.61 2.66e-35 Colorectal cancer; CRC cis rs12701220 0.847 rs10272002 chr7:1047615 A/G cg00990874 chr7:1149470 C7orf50 -0.58 -6.7 -0.35 8.79e-11 Bronchopulmonary dysplasia; CRC cis rs3743266 0.613 rs12442393 chr15:60734460 C/G cg21667061 chr15:60772094 NARG2 -0.29 -5.8 -0.3 1.54e-8 Menarche (age at onset); CRC cis rs7149337 0.836 rs34953083 chr14:51672432 A/G cg23942311 chr14:51606299 NA 0.75 13.7 0.6 3.98e-34 Cancer; CRC cis rs17162190 0.698 rs12046614 chr1:26851729 A/C cg17456097 chr1:26900765 RPS6KA1 0.48 6.09 0.32 3.22e-9 Mean corpuscular volume; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg17010769 chr15:79165973 MORF4L1 0.42 6.7 0.35 8.84e-11 Liver disease severity in Alagille syndrome; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg06079273 chr8:97247865 UQCRB 0.42 6.83 0.35 4.18e-11 Liver disease severity in Alagille syndrome; CRC cis rs9443645 0.901 rs13191068 chr6:79714867 T/C cg09184832 chr6:79620586 NA -0.51 -9.31 -0.46 1.81e-18 Intelligence (multi-trait analysis); CRC cis rs1186222 0.967 rs1179625 chr7:75255491 A/G cg05145297 chr7:75264568 HIP1 0.48 8.42 0.42 1.21e-15 Basophil percentage of granulocytes;White blood cell count (basophil);Basophil percentage of white cells; CRC cis rs6582630 0.502 rs1115515 chr12:38279830 C/T cg26384229 chr12:38710491 ALG10B 0.68 9.2 0.45 4.14e-18 Drug-induced liver injury (flucloxacillin); CRC trans rs10504229 1.000 rs114312649 chr8:58182539 C/G cg04077850 chr5:125800366 GRAMD3 0.37 6.27 0.33 1.15e-9 Developmental language disorder (linguistic errors); CRC cis rs9611565 0.694 rs19573 chr22:41865809 C/A cg06634786 chr22:41940651 POLR3H 0.57 6.99 0.36 1.51e-11 Vitiligo; CRC cis rs6952808 0.929 rs34145223 chr7:1926237 G/A cg21782813 chr7:2030301 MAD1L1 0.47 8.08 0.41 1.22e-14 Bipolar disorder and schizophrenia; CRC cis rs514406 0.798 rs575138 chr1:53328394 C/G cg08859206 chr1:53392774 SCP2 -0.59 -9.58 -0.47 2.38e-19 Monocyte count; CRC cis rs514406 0.505 rs436363 chr1:53172163 T/C cg24675658 chr1:53192096 ZYG11B -0.69 -10.78 -0.51 2.02e-23 Monocyte count; CRC cis rs28386778 0.863 rs58269663 chr17:61843130 G/A cg23090583 chr17:61904693 PSMC5;FTSJ3 1.05 20.23 0.74 1.07e-59 Prudent dietary pattern; CRC cis rs600806 0.850 rs10858085 chr1:109914983 A/G cg23032129 chr1:109941072 SORT1 -0.27 -5.84 -0.31 1.24e-8 Intelligence (multi-trait analysis); CRC cis rs17711722 1.000 rs17711722 chr7:65271197 C/T cg18876405 chr7:65276391 NA -0.67 -12.17 -0.56 2.12e-28 Calcium levels; CRC cis rs68170813 0.559 rs1989814 chr7:107045076 A/G cg02696742 chr7:106810147 HBP1 -0.58 -6.04 -0.32 4.16e-9 Coronary artery disease; CRC cis rs9517320 0.534 rs3825430 chr13:99129653 C/T cg07423050 chr13:99094983 FARP1 -0.56 -8.03 -0.4 1.78e-14 Longevity; CRC cis rs1697139 0.583 rs1428474 chr5:66544015 C/A cg16691251 chr5:66510806 NA 0.44 7.76 0.39 1.09e-13 Breast cancer; CRC cis rs2979489 0.624 rs62505275 chr8:30437639 C/T cg26383811 chr8:30366931 RBPMS -0.62 -9.3 -0.46 1.95e-18 Mean corpuscular hemoglobin;Plateletcrit;Neutrophil count;Granulocyte count;Sum basophil neutrophil counts;Mean corpuscular volume;Myeloid white cell count;Sum neutrophil eosinophil counts; CRC trans rs473651 0.935 rs541013 chr2:239336492 G/A cg13521940 chr21:36262239 RUNX1 -0.41 -6.17 -0.32 1.98e-9 Multiple system atrophy; CRC cis rs12532878 0.652 rs62482223 chr7:100198878 C/A cg00334542 chr7:100209784 MOSPD3 -0.56 -6.59 -0.34 1.71e-10 Mean corpuscular hemoglobin; CRC cis rs10504229 0.679 rs1442125 chr8:58036258 A/C cg02725872 chr8:58115012 NA 0.36 6.07 0.32 3.53e-9 Developmental language disorder (linguistic errors); CRC cis rs798554 0.610 rs2527696 chr7:2858315 T/C cg13628971 chr7:2884303 GNA12 0.42 6.54 0.34 2.37e-10 Height; CRC cis rs4700695 0.925 rs414001 chr5:65383259 C/G cg21114390 chr5:65439923 SFRS12 -0.62 -6.72 -0.35 8.15e-11 Facial morphology (factor 19); CRC cis rs4481887 1.000 rs4430369 chr1:248464330 A/G cg00666640 chr1:248458726 OR2T12 0.54 9.54 0.47 3.31e-19 Common traits (Other); CRC cis rs1552244 1.000 rs6764168 chr3:10123805 A/G cg08888203 chr3:10149979 C3orf24 0.73 10.19 0.49 2.26e-21 Alzheimer's disease; CRC cis rs735539 0.598 rs2290144 chr13:21265658 C/G cg27499820 chr13:21296301 IL17D 0.38 5.69 0.3 2.86e-8 Dental caries; CRC trans rs12495832 0.778 rs1598677 chr3:147932234 A/G cg10221266 chr7:153579447 NA 0.57 6.14 0.32 2.44e-9 Chin dimples; CRC cis rs597539 0.617 rs686348 chr11:68636996 A/G cg06112835 chr11:68658793 MRPL21 0.43 6.88 0.35 3.11e-11 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs12681288 0.823 rs2701907 chr8:1003292 A/G cg04851639 chr8:1020857 NA -0.33 -6.81 -0.35 4.63e-11 Schizophrenia; CRC cis rs2282802 0.685 rs6889283 chr5:139653439 G/T cg26211634 chr5:139558579 C5orf32 0.41 6.95 0.36 2.03e-11 Intelligence (multi-trait analysis); CRC cis rs17539620 0.624 rs871069 chr6:154837578 A/C cg20019720 chr6:154832845 CNKSR3 0.5 8.15 0.41 7.51e-15 Lipoprotein (a) levels; CRC cis rs9733 0.596 rs11582840 chr1:150688487 A/G cg18016565 chr1:150552671 MCL1 0.45 6.52 0.34 2.57e-10 Tonsillectomy; CRC cis rs2760061 0.626 rs2313118 chr1:228118084 T/C cg02753203 chr1:228287806 NA -0.61 -9.15 -0.45 6.2e-18 Diastolic blood pressure; CRC cis rs57221529 0.709 rs72707024 chr5:667915 G/A cg16447950 chr5:562315 NA -0.72 -9.03 -0.45 1.52e-17 Lung disease severity in cystic fibrosis; CRC cis rs875971 0.660 rs62465434 chr7:66005152 A/C cg25985355 chr7:65971099 NA -0.32 -5.67 -0.3 3.12e-8 Aortic root size; CRC cis rs853679 0.517 rs9393884 chr6:28046789 A/G cg12963246 chr6:28129442 ZNF389 0.48 5.76 0.3 1.94e-8 Depression; CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg03160445 chr3:100120349 LNP1;TOMM70A -0.51 -6.04 -0.32 4.17e-9 Diisocyanate-induced asthma; CRC cis rs763121 0.853 rs5757187 chr22:39021522 A/G cg06022373 chr22:39101656 GTPBP1 -0.75 -12.11 -0.56 3.77e-28 Menopause (age at onset); CRC cis rs896854 0.631 rs10097617 chr8:95961626 T/C cg13393036 chr8:95962371 TP53INP1 -0.55 -9.45 -0.46 6.59e-19 Type 2 diabetes; CRC cis rs1032355 1.000 rs1032355 chr4:100539896 C/T cg05468953 chr4:100565104 NA -0.43 -5.84 -0.31 1.28e-8 Celiac disease; CRC trans rs951252 0.504 rs11734405 chr4:146081096 C/T cg00921722 chr16:85061575 KIAA0513 0.48 6.0 0.31 5.19e-9 Hip circumference; CRC cis rs796364 0.951 rs971232 chr2:200792881 C/T cg12253985 chr2:200820533 C2orf60;C2orf47 0.6 6.61 0.34 1.58e-10 Schizophrenia; CRC cis rs17155006 0.664 rs405869 chr7:107742609 T/C cg05962710 chr7:107745446 LAMB4 -0.43 -7.64 -0.39 2.41e-13 Pneumococcal bacteremia; CRC cis rs11229555 0.598 rs1893902 chr11:58190747 A/G cg15696309 chr11:58395628 NA -0.81 -10.27 -0.49 1.19e-21 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; CRC cis rs10870270 0.913 rs115236491 chr10:133766855 T/G cg17892150 chr10:133769511 PPP2R2D -0.74 -10.95 -0.52 5.2e-24 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; CRC cis rs11098499 0.954 rs9998585 chr4:120396802 T/A cg24375607 chr4:120327624 NA 0.49 7.52 0.38 5.23e-13 Corneal astigmatism; CRC trans rs7615952 0.546 rs2976733 chr3:125414138 T/C cg02007433 chr3:129722099 NA -0.61 -9.27 -0.46 2.5e-18 Blood pressure (smoking interaction); CRC cis rs9649213 0.593 rs7458551 chr7:97952167 G/C cg21770322 chr7:97807741 LMTK2 0.51 8.29 0.42 2.88e-15 Prostate cancer (SNP x SNP interaction); CRC trans rs6561151 0.681 rs17462017 chr13:44472235 C/T cg12856521 chr11:46389249 DGKZ 0.81 9.93 0.48 1.73e-20 Crohn's disease; CRC cis rs2991971 0.934 rs11580609 chr1:45975856 C/G cg15605315 chr1:45957053 TESK2 0.42 6.8 0.35 4.86e-11 High light scatter reticulocyte count; CRC cis rs6499255 1.000 rs4497676 chr16:69814950 G/A cg15192750 chr16:69999425 NA 0.58 7.64 0.39 2.43e-13 IgE levels; CRC cis rs1018836 0.923 rs2105967 chr8:91587522 A/G cg16814680 chr8:91681699 NA -0.73 -11.64 -0.54 1.91e-26 Ejection fraction in Tripanosoma cruzi seropositivity; CRC cis rs12760731 0.720 rs12755909 chr1:178305298 G/A cg00404053 chr1:178313656 RASAL2 1.12 11.45 0.53 9.22e-26 Obesity-related traits; CRC cis rs7677751 0.848 rs4635872 chr4:55099041 C/A cg17187183 chr4:55093834 PDGFRA 0.51 7.27 0.37 2.72e-12 Corneal astigmatism; CRC cis rs8180040 0.654 rs6773521 chr3:47234419 A/G cg27129171 chr3:47204927 SETD2 -0.72 -11.39 -0.53 1.46e-25 Colorectal cancer; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg11680855 chr19:54694179 MBOAT7;TSEN34 0.43 6.16 0.32 2.06e-9 Intelligence (multi-trait analysis); CRC cis rs644799 1.000 rs514170 chr11:95556696 C/T cg25478527 chr11:95522999 CEP57;FAM76B 0.52 7.86 0.4 5.6e-14 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs7224685 0.501 rs11650023 chr17:4012850 C/T cg11204139 chr17:3907470 NA -0.77 -14.15 -0.62 7.9e-36 Type 2 diabetes; CRC cis rs6088580 0.634 rs4911152 chr20:32955024 T/C cg08999081 chr20:33150536 PIGU -0.61 -11.29 -0.53 3.21e-25 Glomerular filtration rate (creatinine); CRC cis rs728616 0.867 rs4387301 chr10:81736399 C/T cg05935833 chr10:81318306 SFTPA2 -0.76 -8.28 -0.42 3.12e-15 Chronic obstructive pulmonary disease-related biomarkers; CRC trans rs1005277 0.691 rs2474558 chr10:38486141 A/C cg23533926 chr12:111358616 MYL2 0.49 6.95 0.36 1.97e-11 Extrinsic epigenetic age acceleration; CRC cis rs9443645 0.901 rs9352686 chr6:79758223 T/G cg09184832 chr6:79620586 NA -0.5 -9.23 -0.45 3.45e-18 Intelligence (multi-trait analysis); CRC cis rs10504229 0.645 rs56670121 chr8:58138872 C/T cg05313129 chr8:58192883 C8orf71 -0.43 -6.09 -0.32 3.17e-9 Developmental language disorder (linguistic errors); CRC cis rs1555895 0.599 rs12243303 chr10:861390 C/T cg10556349 chr10:835070 NA -0.38 -7.38 -0.38 1.34e-12 Survival in rectal cancer; CRC cis rs13191362 0.810 rs34714603 chr6:163008078 C/T cg21926612 chr6:163149169 PACRG;PARK2 0.74 10.83 0.51 1.37e-23 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC trans rs1814175 0.684 rs1827015 chr11:49585241 A/G cg11707556 chr5:10655725 ANKRD33B -0.47 -8.74 -0.43 1.19e-16 Height; CRC cis rs1401999 0.966 rs2292998 chr3:183663833 T/C cg05044414 chr3:183734942 ABCC5 0.48 8.32 0.42 2.37e-15 Anterior chamber depth; CRC cis rs735539 0.645 rs9552252 chr13:21192905 C/T cg27499820 chr13:21296301 IL17D 0.44 6.14 0.32 2.32e-9 Dental caries; CRC cis rs589448 0.902 rs528974 chr12:69765918 A/T cg14784868 chr12:69753453 YEATS4 0.91 17.67 0.7 1.31e-49 Cerebrospinal fluid biomarker levels; CRC cis rs611744 0.647 rs12675265 chr8:109268805 C/T cg18478394 chr8:109455254 TTC35 0.39 6.0 0.31 5.12e-9 Dupuytren's disease; CRC cis rs8141529 0.664 rs5762862 chr22:29252732 C/T cg02153584 chr22:29168773 CCDC117 0.48 6.48 0.34 3.45e-10 Lymphocyte counts; CRC cis rs2245008 0.671 rs907036 chr16:83989850 A/T cg07978099 chr16:83986941 OSGIN1 0.55 7.86 0.4 5.44e-14 Pursuit maintenance gain; CRC cis rs9309711 0.666 rs4321399 chr2:3481659 G/A cg15506890 chr2:3487001 NA -0.49 -7.77 -0.39 1.01e-13 Neurofibrillary tangles; CRC cis rs853679 0.550 rs9295762 chr6:28155418 C/T cg15786705 chr6:28176104 NA -0.78 -10.89 -0.51 8.71e-24 Depression; CRC cis rs3733585 0.638 rs13145554 chr4:9979589 C/T cg11266682 chr4:10021025 SLC2A9 0.46 9.26 0.45 2.81e-18 Cleft plate (environmental tobacco smoke interaction); CRC trans rs11088226 0.681 rs2833899 chr21:33933263 T/C cg09050820 chr6:167586206 TCP10L2 0.83 8.82 0.44 6.99e-17 Gastritis; CRC cis rs11997175 0.784 rs36083407 chr8:33812930 G/T ch.8.33884649F chr8:33765107 NA 0.48 6.81 0.35 4.56e-11 Body mass index; CRC cis rs4713118 0.662 rs149969 chr6:27977737 A/G cg02631126 chr6:28058918 ZSCAN12L1 0.25 5.67 0.3 3.13e-8 Parkinson's disease; CRC cis rs2386661 0.591 rs11255051 chr10:5653450 A/G cg12223502 chr10:5658492 NA -0.36 -5.87 -0.31 1.09e-8 Breast cancer; CRC cis rs6570726 0.620 rs12201226 chr6:145913419 A/T cg13319975 chr6:146136371 FBXO30 -0.62 -8.9 -0.44 3.91e-17 Lobe attachment (rater-scored or self-reported); CRC cis rs4716602 0.596 rs10265909 chr7:156158095 T/C cg16983916 chr7:156159713 NA -0.39 -6.92 -0.36 2.42e-11 Anti-saccade response; CRC cis rs13315871 1.000 rs11709976 chr3:58325347 A/G cg20936604 chr3:58311152 NA -0.76 -7.91 -0.4 4.04e-14 Cholesterol, total; CRC trans rs11039798 0.557 rs4436575 chr11:48398894 T/C cg15704280 chr7:45808275 SEPT13 -0.66 -6.94 -0.36 2.15e-11 Axial length; CRC cis rs10751667 0.666 rs7124480 chr11:971601 G/A cg01483505 chr11:975446 AP2A2 0.44 7.09 0.36 8.31e-12 Alzheimer's disease (late onset); CRC cis rs7552404 0.731 rs5745445 chr1:76344332 G/A cg03433033 chr1:76189801 ACADM 0.71 8.54 0.43 5.22e-16 Blood metabolite levels;Acylcarnitine levels; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg27397625 chr6:42952298 PPP2R5D 0.51 6.81 0.35 4.67e-11 Thyroid stimulating hormone; CRC cis rs6502050 0.835 rs7502548 chr17:80087569 T/C cg22110888 chr17:80059540 CCDC57 -0.41 -6.38 -0.33 6.11e-10 Life satisfaction; CRC cis rs2832191 0.755 rs55671430 chr21:30492421 G/C cg24692254 chr21:30365293 RNF160 -0.69 -11.85 -0.55 3.36e-27 Dental caries; CRC cis rs929354 0.742 rs11980541 chr7:156988776 G/C cg05182265 chr7:156933206 UBE3C -0.76 -14.51 -0.62 3.13e-37 Body mass index; CRC cis rs10924970 0.967 rs7553200 chr1:235467940 C/T cg26050004 chr1:235667680 B3GALNT2 0.4 6.0 0.31 5.32e-9 Asthma; CRC cis rs13118159 0.550 rs28614045 chr4:1374695 C/A cg20887711 chr4:1340912 KIAA1530 0.67 9.61 0.47 1.94e-19 Longevity; CRC cis rs7267979 0.844 rs4815413 chr20:25359229 G/T cg24626310 chr20:25276739 ABHD12;PYGB -0.34 -5.69 -0.3 2.75e-8 Liver enzyme levels (alkaline phosphatase); CRC cis rs11864453 0.826 rs2072142 chr16:72132713 C/T cg01557791 chr16:72042693 DHODH -0.47 -6.59 -0.34 1.76e-10 Fibrinogen levels; CRC cis rs7223966 1.000 rs8078862 chr17:61854068 C/T cg23090583 chr17:61904693 PSMC5;FTSJ3 0.5 6.2 0.32 1.69e-9 Hip circumference adjusted for BMI;Body mass index; CRC cis rs9911578 0.704 rs72628393 chr17:56585314 A/T cg05425664 chr17:57184151 TRIM37 0.5 7.86 0.4 5.63e-14 Intelligence (multi-trait analysis); CRC cis rs10504229 0.639 rs66667899 chr8:58117065 C/T cg21724239 chr8:58056113 NA 0.49 6.81 0.35 4.75e-11 Developmental language disorder (linguistic errors); CRC cis rs4474465 1.000 rs10899508 chr11:78170708 T/G cg27205649 chr11:78285834 NARS2 -0.48 -5.85 -0.31 1.18e-8 Alzheimer's disease (survival time); CRC cis rs9916302 0.904 rs2303316 chr17:37704217 A/G cg07936489 chr17:37558343 FBXL20 -0.81 -12.64 -0.57 4.16e-30 Glomerular filtration rate (creatinine); CRC cis rs13108904 0.935 rs1732102 chr4:1277924 T/C cg23123621 chr4:1343375 KIAA1530 -0.34 -6.11 -0.32 2.89e-9 Obesity-related traits; CRC cis rs3796352 1.000 rs2336540 chr3:52974589 G/A cg27565382 chr3:53032988 SFMBT1 0.7 6.16 0.32 2.07e-9 Immune reponse to smallpox (secreted IL-2); CRC trans rs2980439 0.870 rs2945230 chr8:8109936 A/G cg16141378 chr3:129829833 LOC729375 -0.5 -7.69 -0.39 1.75e-13 Neuroticism; CRC cis rs7487075 0.754 rs10880962 chr12:46773444 C/G cg17501823 chr12:47219793 SLC38A4 0.31 5.66 0.3 3.37e-8 Itch intensity from mosquito bite; CRC cis rs9303401 0.659 rs17222691 chr17:56771096 C/T cg10487724 chr17:56770010 TEX14;RAD51C 0.79 9.58 0.47 2.53e-19 Cognitive test performance; CRC cis rs7591163 1.000 rs7574255 chr2:228699884 C/G cg00063174 chr2:228736253 WDR69 0.5 6.65 0.34 1.2e-10 Blood pressure; CRC cis rs7615952 0.641 rs7632497 chr3:125783086 A/C cg02772935 chr3:125709198 NA -0.49 -5.74 -0.3 2.14e-8 Blood pressure (smoking interaction); CRC cis rs11148252 0.904 rs9568734 chr13:53004222 G/A cg02158880 chr13:53174818 NA 0.48 7.28 0.37 2.42e-12 Lewy body disease; CRC cis rs3751196 0.808 rs56147174 chr12:104209661 T/C cg02344784 chr12:104178138 NT5DC3 0.7 7.14 0.37 6.08e-12 Sense of smell; CRC cis rs7429990 0.932 rs2166772 chr3:48047874 C/T cg11946769 chr3:48343235 NME6 -0.45 -5.87 -0.31 1.06e-8 Educational attainment (years of education); CRC cis rs1023500 0.505 rs134891 chr22:42675882 T/C cg15557168 chr22:42548783 NA -0.36 -6.28 -0.33 1.1e-9 Schizophrenia; CRC cis rs2832191 0.935 rs67287920 chr21:30523519 C/A cg24692254 chr21:30365293 RNF160 -0.61 -10.43 -0.5 3.53e-22 Dental caries; CRC cis rs72781680 0.898 rs72781639 chr2:24204148 C/G cg08917208 chr2:24149416 ATAD2B 0.9 9.13 0.45 6.93e-18 Lymphocyte counts; CRC cis rs896854 0.684 rs10099941 chr8:95987008 C/T cg09323728 chr8:95962352 TP53INP1 -0.43 -7.13 -0.37 6.43e-12 Type 2 diabetes; CRC cis rs9894429 1.000 rs7223613 chr17:79574803 C/T cg18240062 chr17:79603768 NPLOC4 -0.56 -9.34 -0.46 1.54e-18 Eye color traits; CRC trans rs61931739 0.500 rs34287388 chr12:34444626 C/A cg26384229 chr12:38710491 ALG10B 0.67 8.89 0.44 4.09e-17 Morning vs. evening chronotype; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg12857786 chr4:83934023 LIN54 0.52 7.46 0.38 7.55e-13 Response to antipsychotic treatment; CRC cis rs1401999 1.000 rs4148575 chr3:183702275 A/G cg20387954 chr3:183756860 HTR3D 0.43 7.37 0.38 1.42e-12 Anterior chamber depth; CRC cis rs28386778 0.897 rs11654841 chr17:61838259 C/T cg06601766 chr17:61851465 DDX42;CCDC47 0.42 5.79 0.3 1.63e-8 Prudent dietary pattern; CRC cis rs8067545 0.640 rs17759083 chr17:19963605 T/A cg13482628 chr17:19912719 NA 0.41 6.09 0.32 3.11e-9 Schizophrenia; CRC cis rs7954584 0.523 rs11043280 chr12:122426643 T/C cg21171335 chr12:122356390 WDR66 0.4 6.04 0.32 4.07e-9 Mean corpuscular volume; CRC cis rs9733 0.621 rs12746899 chr1:150579678 A/T cg17724175 chr1:150552817 MCL1 -0.51 -8.09 -0.41 1.17e-14 Tonsillectomy; CRC cis rs17490626 0.568 rs2033371 chr10:71212310 G/A cg12610070 chr10:71211762 TSPAN15 -0.42 -7.65 -0.39 2.19e-13 Thrombosis; CRC cis rs7264396 0.690 rs2425178 chr20:34446395 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.6 -10.19 -0.49 2.18e-21 Total cholesterol levels; CRC cis rs769267 0.930 rs7254927 chr19:19404786 C/G cg17414380 chr19:19431394 KIAA0892;SF4 0.41 5.64 0.3 3.59e-8 Tonsillectomy; CRC cis rs1005277 0.579 rs2749612 chr10:38488610 G/A cg17219203 chr10:38645113 HSD17B7P2 -0.41 -5.74 -0.3 2.21e-8 Extrinsic epigenetic age acceleration; CRC cis rs4803468 1.000 rs1043413 chr19:41939297 C/G cg09537434 chr19:41945824 ATP5SL 0.91 17.46 0.69 8.75e-49 Height; CRC cis rs853679 0.542 rs34131763 chr6:28075000 A/C cg02631126 chr6:28058918 ZSCAN12L1 0.3 6.11 0.32 2.83e-9 Depression; CRC cis rs4665809 0.556 rs1560869 chr2:26417095 T/C cg04944784 chr2:26401820 FAM59B -0.82 -10.57 -0.5 1.14e-22 Gut microbiome composition (summer); CRC cis rs7712401 0.755 rs1870560 chr5:122111210 G/C cg18764291 chr5:122110994 SNX2 0.43 6.96 0.36 1.82e-11 Mean platelet volume; CRC cis rs311392 0.554 rs376765 chr8:55097188 A/G cg06042504 chr8:55087323 NA -0.37 -5.77 -0.3 1.79e-8 Pelvic organ prolapse (moderate/severe); CRC cis rs769267 0.930 rs1054284 chr19:19616953 T/G cg03709012 chr19:19516395 GATAD2A 0.72 11.17 0.52 8.58e-25 Tonsillectomy; CRC cis rs2346177 0.638 rs34186951 chr2:46657659 A/G cg02822958 chr2:46747628 ATP6V1E2 0.39 6.04 0.32 4.13e-9 HDL cholesterol; CRC cis rs736408 0.609 rs2336545 chr3:52787603 C/T cg07507251 chr3:52567010 NT5DC2 -0.4 -5.8 -0.3 1.53e-8 Bipolar disorder; CRC cis rs10950821 0.881 rs17143180 chr7:20646786 C/G cg02470904 chr7:20686108 ABCB5 0.37 5.9 0.31 8.88e-9 Response to statin therapy; CRC cis rs477692 0.967 rs488143 chr10:131407369 A/C cg05714579 chr10:131428358 MGMT 0.58 8.42 0.42 1.21e-15 Response to temozolomide; CRC cis rs1448094 0.556 rs61930632 chr12:86168937 A/C cg18827107 chr12:86230957 RASSF9 -0.4 -6.24 -0.33 1.38e-9 Major depressive disorder; CRC cis rs798554 0.731 rs2283779 chr7:2815140 G/A cg17321639 chr7:2759063 NA -0.4 -5.74 -0.3 2.2e-8 Height; CRC cis rs2268241 0.938 rs17879003 chr21:34778527 C/T cg14850771 chr21:34775459 IFNGR2 0.76 9.41 0.46 8.77e-19 Obesity-related traits; CRC cis rs1215050 0.782 rs6532693 chr4:98655815 T/C cg05340658 chr4:99064831 C4orf37 -0.47 -7.01 -0.36 1.4e-11 Waist-to-hip ratio adjusted for body mass index; CRC trans rs60843830 1.000 rs11553746 chr2:272203 C/T cg11347411 chr7:150020925 ACTR3C;LRRC61 0.6 9.21 0.45 4.03e-18 Spherical equivalent (joint analysis main effects and education interaction); CRC cis rs9611565 0.694 rs79008 chr22:41850500 C/T cg06634786 chr22:41940651 POLR3H -0.53 -6.61 -0.34 1.54e-10 Vitiligo; CRC trans rs35110281 0.600 rs11089092 chr21:45120994 A/C cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.42 6.69 0.35 9.82e-11 Mean corpuscular volume; CRC cis rs853679 0.517 rs9380060 chr6:28132603 G/A cg21251018 chr6:28226885 NKAPL 0.48 6.17 0.32 2.02e-9 Depression; CRC cis rs9649213 0.574 rs34817002 chr7:97887051 G/A cg24562669 chr7:97807699 LMTK2 0.5 8.5 0.42 6.53e-16 Prostate cancer (SNP x SNP interaction); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg08209163 chr13:28024472 MTIF3 0.39 6.25 0.33 1.3e-9 Liver disease severity in Alagille syndrome; CRC cis rs9467773 0.804 rs2073526 chr6:26374658 C/T cg09904177 chr6:26538194 HMGN4 -0.56 -8.14 -0.41 8.52e-15 Intelligence (multi-trait analysis); CRC trans rs2303319 0.504 rs16846026 chr2:162537691 T/C cg18122310 chr12:50236657 BCDIN3D -0.73 -6.13 -0.32 2.58e-9 Cognitive function; CRC cis rs10504229 0.775 rs17805146 chr8:58161484 G/A cg05313129 chr8:58192883 C8orf71 -0.49 -6.21 -0.32 1.55e-9 Developmental language disorder (linguistic errors); CRC cis rs7618915 0.508 rs13065851 chr3:52644836 T/A cg15147215 chr3:52552868 STAB1 -0.62 -10.27 -0.49 1.2e-21 Bipolar disorder; CRC cis rs11583043 0.918 rs6693456 chr1:101424561 A/G cg16556008 chr1:101360663 SLC30A7;EXTL2 0.52 7.08 0.36 8.54e-12 Ulcerative colitis;Inflammatory bowel disease; CRC cis rs12142240 0.698 rs6695043 chr1:46844530 A/G cg00530320 chr1:46809349 NSUN4 -0.61 -7.93 -0.4 3.39e-14 Menopause (age at onset); CRC cis rs4862750 0.832 rs10007858 chr4:187877492 A/G cg03452623 chr4:187889614 NA -0.91 -21.44 -0.76 2.02e-64 Lobe attachment (rater-scored or self-reported); CRC cis rs449789 0.857 rs10455775 chr6:159723721 C/T cg14500486 chr6:159655392 FNDC1 -0.49 -7.26 -0.37 2.84e-12 Pulse pressure; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg06604058 chr11:63448992 RTN3 0.46 7.41 0.38 1.04e-12 Liver disease severity in Alagille syndrome; CRC cis rs270601 0.955 rs273911 chr5:131661526 C/G cg22638593 chr5:131593259 PDLIM4 0.39 6.37 0.33 6.2e-10 Acylcarnitine levels; CRC cis rs1005277 0.522 rs289649 chr10:37975384 T/C cg00409905 chr10:38381863 ZNF37A -0.64 -10.42 -0.5 3.65e-22 Extrinsic epigenetic age acceleration; CRC cis rs9318086 0.648 rs9507184 chr13:24473642 T/C cg25267304 chr13:24462978 PCOTH;MIPEP 0.64 10.27 0.49 1.24e-21 Myopia (pathological); CRC cis rs17065868 0.764 rs7996107 chr13:45033506 T/C cg10246903 chr13:45222710 NA 0.54 5.69 0.3 2.79e-8 Antineutrophil cytoplasmic antibody-associated vasculitis; CRC cis rs7107174 0.892 rs2510042 chr11:77923665 C/T cg02023728 chr11:77925099 USP35 0.52 7.8 0.4 8.25e-14 Testicular germ cell tumor; CRC cis rs7772486 0.597 rs9386136 chr6:146158300 A/T cg05347473 chr6:146136440 FBXO30 0.5 7.2 0.37 4.16e-12 Lobe attachment (rater-scored or self-reported); CRC cis rs4888262 0.526 rs7193423 chr16:74626340 A/C cg01733217 chr16:74700730 RFWD3 0.8 11.79 0.54 5.55e-27 Testicular germ cell tumor; CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg22998610 chr11:62538411 TAF6L 0.37 6.07 0.32 3.53e-9 Obesity-related traits; CRC cis rs1799949 0.896 rs35908185 chr17:41255111 A/T cg23758822 chr17:41437982 NA 0.8 13.55 0.6 1.54e-33 Menopause (age at onset); CRC cis rs58688157 0.705 rs12795572 chr11:590999 G/A cg09218773 chr11:619014 MUPCDH -0.44 -6.32 -0.33 8.32e-10 Systemic lupus erythematosus; CRC cis rs4713675 0.565 rs6928010 chr6:33676590 T/C cg14003231 chr6:33640908 ITPR3 0.51 8.28 0.42 3.03e-15 Plateletcrit; CRC cis rs6500602 0.609 rs7202910 chr16:4518948 T/A cg08645402 chr16:4508243 NA 0.52 7.75 0.39 1.19e-13 Schizophrenia; CRC cis rs7264396 0.775 rs2296402 chr20:34054729 T/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.38 -6.07 -0.32 3.43e-9 Total cholesterol levels; CRC cis rs11674184 0.714 rs16857668 chr2:11723110 G/A cg07314298 chr2:11723111 GREB1 -0.66 -12.06 -0.55 5.44e-28 Endometriosis; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg11827097 chr2:231280903 SP100 0.46 6.6 0.34 1.61e-10 Response to antipsychotic treatment; CRC cis rs6460942 0.915 rs6966791 chr7:12439714 T/C cg20607287 chr7:12443886 VWDE -0.68 -7.26 -0.37 2.76e-12 Coronary artery disease; CRC cis rs926938 0.527 rs360580 chr1:115462334 A/G cg12756093 chr1:115239321 AMPD1 0.48 6.99 0.36 1.51e-11 Autism; CRC trans rs875971 0.660 rs2191268 chr7:66110224 C/T cg17059624 chr11:85358760 TMEM126A -0.38 -6.02 -0.31 4.63e-9 Aortic root size; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg23850377 chr2:20251576 LAPTM4A 0.49 6.28 0.33 1.05e-9 Thyroid stimulating hormone; CRC cis rs853679 0.546 rs200990 chr6:27815823 T/G cg19041857 chr6:27730383 NA -0.75 -7.32 -0.37 1.93e-12 Depression; CRC trans rs2303319 0.504 rs35304298 chr2:162617185 G/T cg10272801 chr16:14013773 ERCC4 -0.68 -6.07 -0.32 3.49e-9 Cognitive function; CRC cis rs2836974 0.897 rs2836944 chr21:40593539 G/A cg11890956 chr21:40555474 PSMG1 1.08 18.41 0.71 1.56e-52 Cognitive function; CRC trans rs16846053 0.681 rs62187569 chr2:162373517 A/G cg09481857 chr22:21368659 P2RX6;MGC16703 -0.64 -6.11 -0.32 2.75e-9 Blood osmolality (transformed sodium); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg27665769 chr4:2757761 TNIP2 0.41 6.25 0.33 1.28e-9 Intelligence (multi-trait analysis); CRC cis rs447735 0.565 rs10852626 chr16:89914633 T/G cg04287289 chr16:89883240 FANCA 0.56 8.46 0.42 9.18e-16 Hemoglobin concentration; CRC cis rs7804356 1.000 rs3801803 chr7:26901740 T/C cg03456212 chr7:26904342 SKAP2 -0.5 -5.77 -0.3 1.88e-8 Type 1 diabetes; CRC cis rs12760731 0.544 rs34163217 chr1:178586984 C/T cg00404053 chr1:178313656 RASAL2 0.6 7.19 0.37 4.26e-12 Obesity-related traits; CRC cis rs9527 0.551 rs28606370 chr10:104670832 C/A cg08772003 chr10:104629869 AS3MT -0.36 -6.09 -0.32 3.22e-9 Arsenic metabolism; CRC cis rs10512697 0.772 rs13176060 chr5:3522987 C/T cg19473799 chr5:3511975 NA -0.83 -6.34 -0.33 7.66e-10 Immune response to smallpox vaccine (IL-6); CRC trans rs9858542 0.953 rs9811982 chr3:49624377 A/C cg21582582 chr3:182698605 DCUN1D1 -0.54 -6.68 -0.35 1.01e-10 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs7312933 0.533 rs3747557 chr12:42717961 G/T cg19980929 chr12:42632907 YAF2 -0.39 -5.9 -0.31 9.12e-9 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CRC trans rs8073060 0.586 rs6505485 chr17:33996102 C/T cg19694781 chr19:47549865 TMEM160 -0.98 -12.75 -0.58 1.5e-30 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; CRC cis rs2976388 0.609 rs2717603 chr8:143803193 T/C cg12516270 chr8:143859308 LYNX1 0.43 7.57 0.39 3.83e-13 Urinary tract infection frequency; CRC cis rs2882667 0.931 rs10070021 chr5:138324706 A/G cg04439458 chr5:138467593 SIL1 -0.31 -5.74 -0.3 2.15e-8 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs9462027 0.585 rs2814974 chr6:34572028 A/C cg07306190 chr6:34760872 UHRF1BP1 -0.34 -6.04 -0.32 4.08e-9 Systemic lupus erythematosus; CRC cis rs1129187 0.755 rs13215983 chr6:42924193 C/T cg21280719 chr6:42927975 GNMT -0.46 -10.31 -0.49 8.47e-22 Alzheimer's disease in APOE e4+ carriers; CRC cis rs12200560 0.505 rs172425 chr6:97075299 A/T cg06623918 chr6:96969491 KIAA0776 0.52 7.76 0.39 1.08e-13 Coronary heart disease; CRC cis rs77633900 0.614 rs2930681 chr15:76995150 G/A cg21673338 chr15:77095150 SCAPER -0.75 -7.89 -0.4 4.44e-14 Non-glioblastoma glioma;Glioma; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg01307092 chr12:53473443 SPRYD3 0.47 6.58 0.34 1.81e-10 Anxiety disorder; CRC cis rs12477438 0.765 rs6740054 chr2:99576631 C/T cg26064155 chr2:99771622 LIPT1;TSGA10 -0.62 -8.66 -0.43 2.14e-16 Chronic sinus infection; CRC cis rs9399135 0.967 rs9373122 chr6:135373534 G/A cg24558204 chr6:135376177 HBS1L 0.49 7.72 0.39 1.42e-13 Red blood cell count; CRC trans rs7618501 0.633 rs13060128 chr3:50025028 A/G cg21665057 chr3:196295764 WDR53;FBXO45 0.58 9.27 0.46 2.53e-18 Intelligence (multi-trait analysis); CRC cis rs8017423 0.569 rs10141476 chr14:90823351 C/T cg14092571 chr14:90743983 NA 0.38 5.92 0.31 8.07e-9 Mortality in heart failure; CRC cis rs798766 1.000 rs3099555 chr4:1725651 T/C cg02089348 chr4:1724449 TMEM129;TACC3 -0.39 -5.66 -0.3 3.33e-8 Bladder cancer;Urinary bladder cancer; CRC cis rs736408 0.634 rs11717836 chr3:52807736 A/G cg11645453 chr3:52864694 ITIH4 0.38 6.43 0.33 4.41e-10 Bipolar disorder; CRC cis rs798554 0.610 rs1182209 chr7:2808595 C/T cg19717773 chr7:2847554 GNA12 -0.45 -7.51 -0.38 5.51e-13 Height; CRC cis rs8060686 0.920 rs73591976 chr16:67811590 C/A cg08314208 chr16:67682810 RLTPR -0.65 -7.04 -0.36 1.12e-11 HDL cholesterol;Metabolic syndrome; CRC cis rs892961 0.899 rs747482 chr17:75412109 T/C cg05865280 chr17:75406074 SEPT9 0.62 14.3 0.62 2.08e-36 Airflow obstruction; CRC cis rs9648716 1.000 rs10234502 chr7:140522553 C/T cg10747023 chr7:140774559 NA 0.44 5.76 0.3 1.94e-8 Type 2 diabetes; CRC cis rs28386778 0.724 rs35092235 chr17:61944621 T/C cg23090583 chr17:61904693 PSMC5;FTSJ3 1.03 19.42 0.73 1.63e-56 Prudent dietary pattern; CRC cis rs514406 0.505 rs427319 chr1:53178807 T/G cg08859206 chr1:53392774 SCP2 -0.4 -6.09 -0.32 3.1e-9 Monocyte count; CRC trans rs116095464 0.558 rs28729548 chr5:229025 C/T cg00938859 chr5:1591904 SDHAP3 0.72 7.96 0.4 2.76e-14 Breast cancer; CRC cis rs4820294 1.000 rs62236667 chr22:38061520 C/G cg21798802 chr22:38057573 PDXP 0.47 7.7 0.39 1.63e-13 Fat distribution (HIV); CRC cis rs6964587 1.000 rs10243241 chr7:91705696 A/G cg17063962 chr7:91808500 NA 0.78 13.66 0.6 5.73e-34 Breast cancer; CRC cis rs523522 0.962 rs10744752 chr12:120900554 T/G cg12219531 chr12:120966889 COQ5 0.63 8.42 0.42 1.18e-15 High light scatter reticulocyte count; CRC cis rs9911578 0.967 rs8082544 chr17:57185807 C/T cg12560992 chr17:57184187 TRIM37 -0.95 -17.85 -0.7 2.47e-50 Intelligence (multi-trait analysis); CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg10691036 chr19:49622443 C19orf73;PPFIA3 0.47 6.2 0.32 1.68e-9 Anxiety disorder; CRC cis rs875971 1.000 rs1144895 chr7:65541307 C/G cg00343986 chr7:65444356 GUSB -0.47 -6.94 -0.36 2.05e-11 Aortic root size; CRC cis rs6952808 1.000 rs4721122 chr7:1893311 C/G cg02951883 chr7:2050386 MAD1L1 -0.66 -10.53 -0.5 1.52e-22 Bipolar disorder and schizophrenia; CRC cis rs3018066 0.867 rs4374692 chr4:107150985 A/G cg01869342 chr4:106983673 TBCK -0.36 -5.63 -0.3 3.82e-8 Cancer; CRC cis rs2067615 0.507 rs10746063 chr12:107086240 G/T cg15890332 chr12:107067104 RFX4 0.32 5.62 0.3 4.12e-8 Heart rate; CRC cis rs2077654 0.822 rs7944045 chr11:17439590 C/T cg25308976 chr11:17434268 ABCC8 0.78 7.95 0.4 2.94e-14 Gout; CRC cis rs56176327 0.600 rs7628207 chr3:49754970 T/C cg13072238 chr3:49761600 GMPPB -0.48 -5.68 -0.3 2.89e-8 Intelligence (multi-trait analysis); CRC cis rs6662572 0.703 rs72690847 chr1:46256929 A/G cg08644498 chr1:46502608 NA 0.44 6.85 0.35 3.61e-11 Blood protein levels; CRC cis rs6582630 0.519 rs9738104 chr12:38338459 A/C cg13010199 chr12:38710504 ALG10B 0.44 5.63 0.3 3.82e-8 Drug-induced liver injury (flucloxacillin); CRC trans rs10838798 0.504 rs11039530 chr11:48145746 C/T cg21153622 chr11:89784906 NA -0.45 -7.26 -0.37 2.84e-12 Height; CRC cis rs2014572 0.967 rs8112572 chr19:57759612 T/C cg24459738 chr19:57751996 ZNF805 -0.58 -9.16 -0.45 5.88e-18 Hyperactive-impulsive symptoms; CRC cis rs763121 0.889 rs9610971 chr22:38910810 C/T cg06544989 chr22:39130855 UNC84B 0.41 6.04 0.32 4.12e-9 Menopause (age at onset); CRC cis rs736801 0.808 rs2706403 chr5:131799012 A/G cg14196790 chr5:131705035 SLC22A5 -0.35 -5.77 -0.3 1.87e-8 Breast cancer;Mosquito bite size; CRC cis rs73200209 0.744 rs17498480 chr12:116558916 A/T cg01776926 chr12:116560359 MED13L -0.6 -7.21 -0.37 3.92e-12 Total body bone mineral density; CRC cis rs1278769 0.786 rs7998551 chr13:113540649 G/T cg00823993 chr13:113535758 ATP11A 0.65 8.76 0.43 1.06e-16 Interstitial lung disease; CRC trans rs1814175 0.645 rs847627 chr11:49927177 G/A cg11707556 chr5:10655725 ANKRD33B -0.52 -9.95 -0.48 1.49e-20 Height; CRC cis rs8031584 0.541 rs1983459 chr15:31208749 C/T cg08704250 chr15:31115839 NA -0.3 -5.66 -0.3 3.26e-8 Huntington's disease progression; CRC cis rs7937682 0.593 rs1944118 chr11:111352032 A/G cg09085632 chr11:111637200 PPP2R1B -0.41 -5.87 -0.31 1.07e-8 Primary sclerosing cholangitis; CRC cis rs12024301 0.557 rs79519767 chr1:183598988 G/C cg11505048 chr1:183622726 RGL1;APOBEC4 0.76 6.93 0.36 2.16e-11 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs7945705 0.783 rs11042125 chr11:8938049 A/T cg21881798 chr11:8931708 C11orf17;ST5 -0.65 -10.03 -0.48 7.85e-21 Hemoglobin concentration; CRC cis rs875971 0.825 rs1860472 chr7:66082723 T/C cg12463550 chr7:65579703 CRCP -0.47 -6.3 -0.33 9.38e-10 Aortic root size; CRC cis rs853679 0.517 rs9368556 chr6:28131153 T/C cg25164649 chr6:28176230 NA 0.78 9.66 0.47 1.33e-19 Depression; CRC cis rs4969178 0.645 rs4490057 chr17:76375095 C/T cg05887092 chr17:76393375 PGS1 -0.62 -12.32 -0.56 6.13e-29 HDL cholesterol levels; CRC cis rs12497850 0.931 rs9682444 chr3:48852639 A/G cg20833759 chr3:49053208 WDR6;DALRD3 0.53 9.14 0.45 6.55e-18 Parkinson's disease; CRC cis rs2346177 0.519 rs35509718 chr2:46696793 T/C cg02822958 chr2:46747628 ATP6V1E2 0.42 5.94 0.31 7.33e-9 HDL cholesterol; CRC trans rs7829975 0.711 rs12682352 chr8:8646246 A/G cg16141378 chr3:129829833 LOC729375 -0.45 -7.18 -0.37 4.62e-12 Mood instability; CRC cis rs7072216 0.881 rs7082192 chr10:100151844 T/C cg26618903 chr10:100175079 PYROXD2 -0.36 -6.04 -0.32 4.16e-9 Metabolite levels; CRC trans rs10983614 1.000 rs7867776 chr9:120072627 A/G cg15166552 chr3:156273067 SSR3 0.44 6.09 0.32 3.23e-9 Survival in pancreatic cancer; CRC cis rs9462846 0.853 rs7758629 chr6:42871264 C/A cg21280719 chr6:42927975 GNMT -0.33 -6.47 -0.34 3.65e-10 Blood protein levels; CRC cis rs6748734 1.000 rs4675868 chr2:241828542 A/C cg07537917 chr2:241836409 C2orf54 -0.22 -6.09 -0.32 3.12e-9 Urinary metabolites; CRC cis rs10189230 0.967 rs13026378 chr2:222352712 G/A cg14652038 chr2:222343519 EPHA4 0.52 10.09 0.49 4.79e-21 Urate levels in lean individuals; CRC cis rs2976388 0.556 rs4736323 chr8:143830359 C/T cg24046110 chr8:143859143 LYNX1 -0.4 -5.91 -0.31 8.55e-9 Urinary tract infection frequency; CRC cis rs4975709 0.610 rs4975704 chr5:1859807 C/A cg11168104 chr5:1857477 NA -0.39 -6.65 -0.34 1.2e-10 Cardiovascular disease risk factors; CRC cis rs7917772 0.503 rs10883732 chr10:104293461 G/A cg04362960 chr10:104952993 NT5C2 -0.41 -5.79 -0.3 1.62e-8 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC cis rs4713118 0.513 rs149951 chr6:28033087 T/C cg03623178 chr6:28175578 NA 0.77 11.49 0.54 6.21e-26 Parkinson's disease; CRC cis rs7100689 0.784 rs6585986 chr10:82171559 T/C cg00277334 chr10:82204260 NA -0.44 -5.8 -0.3 1.55e-8 Post bronchodilator FEV1; CRC cis rs117623576 0.680 rs740859 chr10:32361839 G/A cg03047570 chr10:32398778 NA -0.59 -6.05 -0.32 3.94e-9 Anti-saccade response; CRC cis rs9640161 0.750 rs3735167 chr7:150039555 C/T cg13722127 chr7:150037890 RARRES2 0.48 7.08 0.36 8.54e-12 Blood protein levels;Circulating chemerin levels; CRC cis rs6502050 0.835 rs7222057 chr17:80087647 C/A cg13198984 chr17:80129470 CCDC57 0.48 8.58 0.43 3.86e-16 Life satisfaction; CRC cis rs7769051 0.522 rs57176306 chr6:133142168 C/T cg22852734 chr6:133119734 C6orf192 0.93 7.26 0.37 2.82e-12 Type 2 diabetes nephropathy; CRC cis rs908922 0.961 rs574749 chr1:152460672 T/G cg23254163 chr1:152506842 NA 0.41 6.71 0.35 8.42e-11 Hair morphology; CRC cis rs10979 1.000 rs9390112 chr6:143896147 G/A cg25407410 chr6:143891975 LOC285740 -0.84 -13.64 -0.6 6.97e-34 Hypospadias; CRC cis rs7085104 0.572 rs284860 chr10:104572963 T/C cg23093090 chr10:104574429 C10orf26 0.4 6.65 0.34 1.19e-10 Immature fraction of reticulocytes;Schizophrenia; CRC cis rs2281845 0.965 rs7516023 chr1:201085521 C/T cg24849736 chr1:201084428 NA 0.66 12.31 0.56 6.96e-29 Permanent tooth development; CRC cis rs1215050 0.791 rs9993992 chr4:98810851 C/G cg05340658 chr4:99064831 C4orf37 0.47 6.83 0.35 4.02e-11 Waist-to-hip ratio adjusted for body mass index; CRC cis rs73206853 0.841 rs56065235 chr12:111016287 C/T cg12870014 chr12:110450643 ANKRD13A 0.77 7.23 0.37 3.44e-12 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC cis rs6840360 0.582 rs6813735 chr4:152326990 T/G cg09659197 chr4:152720779 NA 0.3 5.66 0.3 3.28e-8 Intelligence (multi-trait analysis); CRC trans rs7618501 0.521 rs6774354 chr3:49961780 G/A cg21665057 chr3:196295764 WDR53;FBXO45 0.48 7.07 0.36 9.57e-12 Intelligence (multi-trait analysis); CRC cis rs9381040 0.610 rs9367094 chr6:41017860 T/C cg25110423 chr6:41068646 NFYA;LOC221442 -0.37 -5.75 -0.3 2.08e-8 Alzheimer's disease (late onset); CRC cis rs4073582 1.000 rs524859 chr11:66041079 G/A cg14036092 chr11:66035641 RAB1B 0.59 8.69 0.43 1.78e-16 Gout; CRC cis rs7212938 0.509 rs62068170 chr17:38103210 G/A cg17467752 chr17:38218738 THRA 0.41 6.14 0.32 2.42e-9 Asthma and hay fever; CRC cis rs2274273 0.840 rs6573014 chr14:55735892 C/T cg23234261 chr14:55582407 NA 0.3 5.93 0.31 7.49e-9 Protein biomarker; CRC cis rs360798 0.512 rs2058566 chr2:63179076 C/T cg17519650 chr2:63277830 OTX1 0.46 6.45 0.34 3.88e-10 Coronary artery disease; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg10243681 chr15:73925924 NPTN 0.46 6.66 0.34 1.17e-10 Response to antipsychotic treatment; CRC cis rs2408955 0.522 rs6580650 chr12:48418556 G/T cg24011408 chr12:48396354 COL2A1 -0.44 -6.32 -0.33 8.34e-10 Glycated hemoglobin levels; CRC cis rs68170813 0.559 rs77671232 chr7:106939202 A/G cg02696742 chr7:106810147 HBP1 -0.51 -5.94 -0.31 7.45e-9 Coronary artery disease; CRC cis rs473651 0.935 rs559579 chr2:239339501 G/C cg08773314 chr2:239334832 ASB1 0.37 7.76 0.39 1.11e-13 Multiple system atrophy; CRC cis rs2160860 0.965 rs2729462 chr8:39822139 T/C cg11363097 chr8:39792086 IDO2 -0.35 -5.6 -0.3 4.5e-8 Blood metabolite levels; CRC cis rs1552244 0.882 rs55808392 chr3:10054681 C/T cg18598329 chr3:10140678 FANCD2;C3orf24 -0.83 -10.71 -0.51 3.76e-23 Alzheimer's disease; CRC cis rs561341 0.882 rs72825748 chr17:30367396 G/A cg00745463 chr17:30367425 LRRC37B -0.88 -9.69 -0.47 1.04e-19 Hip circumference adjusted for BMI; CRC cis rs7647973 1.000 rs9871024 chr3:49554241 T/C cg07690219 chr3:49449608 TCTA;RHOA 0.53 5.98 0.31 5.69e-9 Menarche (age at onset); CRC cis rs274567 0.602 rs272853 chr5:131688561 A/G cg11843238 chr5:131593191 PDLIM4 0.42 7.28 0.37 2.49e-12 Blood metabolite levels; CRC trans rs6066835 0.572 rs11698365 chr20:47259527 C/T cg21109867 chr19:55897418 RPL28 -0.84 -6.29 -0.33 1.01e-9 Multiple myeloma; CRC cis rs798766 1.000 rs3752749 chr4:1737262 T/C cg05874882 chr4:1763078 NA -0.39 -7.01 -0.36 1.32e-11 Bladder cancer;Urinary bladder cancer; CRC trans rs11581859 0.950 rs55831817 chr1:99373559 G/T cg12183875 chr3:169587454 LRRC31 0.28 6.4 0.33 5.49e-10 Response to cognitive-behavioural therapy in anxiety disorder; CRC cis rs10046574 0.634 rs10266715 chr7:135155366 C/T cg27474649 chr7:135195673 CNOT4 -0.65 -5.71 -0.3 2.59e-8 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs9611565 0.592 rs5758427 chr22:42099688 A/G cg03806693 chr22:41940476 POLR3H 1.0 12.92 0.58 3.72e-31 Vitiligo; CRC cis rs9649213 0.593 rs6973775 chr7:98004685 G/A cg24562669 chr7:97807699 LMTK2 0.44 7.28 0.37 2.5e-12 Prostate cancer (SNP x SNP interaction); CRC cis rs1059312 0.808 rs10847693 chr12:129292006 G/A cg23521905 chr12:129298690 SLC15A4;MGC16384 0.37 6.51 0.34 2.85e-10 Systemic lupus erythematosus; CRC cis rs870825 0.929 rs72689269 chr4:185592085 T/C cg04058563 chr4:185651563 MLF1IP 0.63 6.64 0.34 1.29e-10 Blood protein levels; CRC cis rs9372498 0.536 rs62422221 chr6:118925581 T/C cg01339444 chr6:118972232 C6orf204 0.51 5.61 0.3 4.29e-8 Diastolic blood pressure; CRC cis rs1878931 0.582 rs27231 chr16:3434966 C/T cg26668626 chr16:3451006 ZNF174;ZNF434 0.51 6.24 0.33 1.35e-9 Body mass index (adult); CRC cis rs2019137 0.539 rs4849177 chr2:113982584 T/C cg09704166 chr2:114031854 PAX8;LOC440839 -0.35 -6.63 -0.34 1.37e-10 Lymphocyte counts; CRC cis rs7487075 0.780 rs12296120 chr12:46737591 G/A cg22049899 chr12:47219821 SLC38A4 0.36 7.31 0.37 2.08e-12 Itch intensity from mosquito bite; CRC cis rs780096 0.546 rs2293572 chr2:27728777 C/G cg17158414 chr2:27665306 KRTCAP3 0.28 5.98 0.31 5.97e-9 Total body bone mineral density; CRC cis rs11155671 0.530 rs9383940 chr6:150226059 T/G cg05861140 chr6:150128134 PCMT1 -0.35 -5.82 -0.31 1.37e-8 Testicular germ cell tumor; CRC cis rs9894429 0.646 rs8079963 chr17:79603285 C/T cg21984481 chr17:79567631 NPLOC4 -0.45 -7.83 -0.4 6.9e-14 Eye color traits; CRC cis rs1865760 1.000 rs12209482 chr6:25909229 T/G cg17691542 chr6:26056736 HIST1H1C 0.55 8.35 0.42 1.88e-15 Height; CRC cis rs66782572 1 rs66782572 chr3:52567617 A/G cg07507251 chr3:52567010 NT5DC2 0.57 9.42 0.46 8.11e-19 Hemoglobin concentration; CRC cis rs873946 0.586 rs12259688 chr10:134549628 A/G cg26818010 chr10:134567672 INPP5A -0.65 -8.6 -0.43 3.37e-16 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CRC cis rs9322193 1.000 rs9322193 chr6:149919143 T/G cg13206674 chr6:150067644 NUP43 0.57 8.26 0.41 3.69e-15 Lung cancer; CRC cis rs9910055 0.762 rs6503489 chr17:42246289 G/A cg16434002 chr17:42200994 HDAC5 -0.46 -6.42 -0.33 4.63e-10 Total body bone mineral density; CRC cis rs7618915 0.501 rs13085775 chr3:52678370 C/T cg10802521 chr3:52805072 NEK4 -0.56 -8.9 -0.44 3.79e-17 Bipolar disorder; CRC cis rs6460942 0.558 rs4330594 chr7:12278615 G/A cg20607287 chr7:12443886 VWDE -0.53 -5.68 -0.3 2.93e-8 Coronary artery disease; CRC cis rs62064224 0.614 rs9916114 chr17:30766950 T/C cg18200150 chr17:30822561 MYO1D 0.47 8.85 0.44 5.39e-17 Schizophrenia; CRC cis rs4332037 0.539 rs34571717 chr7:2106855 T/C cg23422044 chr7:1970798 MAD1L1 -0.41 -5.67 -0.3 3.13e-8 Bipolar disorder; CRC cis rs1799949 1.000 rs8176234 chr17:41219780 T/C cg25072359 chr17:41440525 NA 0.47 7.04 0.36 1.11e-11 Menopause (age at onset); CRC cis rs4862750 0.914 rs9995391 chr4:187873749 A/T cg22105103 chr4:187893119 NA -0.59 -10.44 -0.5 3.11e-22 Lobe attachment (rater-scored or self-reported); CRC cis rs514406 0.861 rs2065477 chr1:53250213 C/T cg27535305 chr1:53392650 SCP2 -0.35 -6.16 -0.32 2.13e-9 Monocyte count; CRC cis rs10504229 1.000 rs6987435 chr8:58177334 G/A cg22535103 chr8:58192502 C8orf71 -0.79 -11.91 -0.55 2.01e-27 Developmental language disorder (linguistic errors); CRC cis rs9300255 0.516 rs6488868 chr12:123799974 A/G cg00376283 chr12:123451042 ABCB9 0.58 8.51 0.42 6.33e-16 Neutrophil percentage of white cells; CRC cis rs7680126 0.672 rs4697957 chr4:10182254 A/G cg00071950 chr4:10020882 SLC2A9 -0.46 -5.95 -0.31 6.92e-9 Urate levels in lean individuals;Urate levels in overweight individuals;Urate levels in obese individuals; CRC cis rs4731207 0.596 rs7779594 chr7:124636995 T/C cg23710748 chr7:124431027 NA -0.39 -6.26 -0.33 1.17e-9 Cutaneous malignant melanoma; CRC cis rs78456975 1.000 rs111935361 chr2:1554192 C/A cg12573674 chr2:1569213 NA -0.76 -7.84 -0.4 6.48e-14 Placebo response in major depressive disorder (% change in symptom score); CRC cis rs1046896 0.594 rs9914570 chr17:80783721 C/T cg19046167 chr17:80928561 B3GNTL1 0.5 6.87 0.35 3.3e-11 Glycated hemoglobin levels; CRC cis rs896854 0.654 rs13278601 chr8:95972974 G/C cg13393036 chr8:95962371 TP53INP1 -0.54 -9.28 -0.46 2.41e-18 Type 2 diabetes; CRC cis rs6456156 0.846 rs7749827 chr6:167515624 C/T cg07741184 chr6:167504864 NA -0.35 -6.0 -0.31 5.31e-9 Primary biliary cholangitis; CRC cis rs1552244 0.554 rs34391585 chr3:9999208 G/C cg13047869 chr3:10149882 C3orf24 0.36 5.73 0.3 2.27e-8 Alzheimer's disease; CRC cis rs733592 0.507 rs10747529 chr12:48473369 G/A cg21466736 chr12:48725269 NA 0.51 7.97 0.4 2.6e-14 Plateletcrit; CRC cis rs10504229 0.639 rs2291764 chr8:58142943 A/C cg21724239 chr8:58056113 NA 0.76 9.33 0.46 1.63e-18 Developmental language disorder (linguistic errors); CRC cis rs7640424 0.819 rs162070 chr3:107835448 G/A cg09227934 chr3:107805635 CD47 0.44 6.52 0.34 2.59e-10 Body mass index; CRC cis rs2077654 0.818 rs73423040 chr11:17436568 A/T cg25308976 chr11:17434268 ABCC8 0.66 6.75 0.35 6.58e-11 Gout; CRC cis rs910316 0.737 rs424120 chr14:75482828 G/T cg03030879 chr14:75389066 RPS6KL1 0.43 6.54 0.34 2.35e-10 Height; CRC cis rs10504229 1.000 rs66477954 chr8:58187810 C/T cg05313129 chr8:58192883 C8orf71 -0.47 -6.99 -0.36 1.49e-11 Developmental language disorder (linguistic errors); CRC cis rs2180341 0.920 rs7756880 chr6:127683999 A/T cg27446573 chr6:127587934 RNF146 0.97 13.77 0.6 2.17e-34 Breast cancer; CRC cis rs3540 0.920 rs7182658 chr15:91019248 A/T cg04176472 chr15:90893244 GABARAPL3 0.36 6.16 0.32 2.12e-9 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; CRC cis rs17092148 1.000 rs6060047 chr20:33367400 G/T cg08999081 chr20:33150536 PIGU -0.42 -5.79 -0.3 1.68e-8 Neuroticism; CRC trans rs8108034 0.920 rs30480 chr19:39807213 A/G cg15829294 chr19:12606397 ZNF709 -0.51 -6.19 -0.32 1.83e-9 Lung adenocarcinoma; CRC cis rs7949030 0.591 rs11231156 chr11:62366454 G/A cg11742103 chr11:62369870 EML3;MTA2 0.62 11.71 0.54 1e-26 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; CRC cis rs7727544 0.506 rs10040809 chr5:131343017 A/C cg12564285 chr5:131593104 PDLIM4 0.33 5.87 0.31 1.08e-8 Blood metabolite levels; CRC cis rs2795502 1.000 rs2142991 chr10:43341105 C/T cg27426351 chr10:43362370 NA -0.6 -7.08 -0.36 8.62e-12 Blood protein levels; CRC cis rs13191362 1.000 rs66594243 chr6:163169024 T/C cg23758597 chr6:163146217 PARK2 -0.71 -7.21 -0.37 3.75e-12 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs6504622 0.905 rs9898981 chr17:45026715 T/G cg16759221 chr17:45003025 GOSR2 -0.52 -8.19 -0.41 6.02e-15 Orofacial clefts; CRC cis rs6860806 0.507 rs272868 chr5:131680751 C/G cg11843238 chr5:131593191 PDLIM4 0.42 7.19 0.37 4.26e-12 Breast cancer; CRC cis rs1862618 0.853 rs10051747 chr5:56083289 C/A cg03609598 chr5:56110824 MAP3K1 -0.81 -9.74 -0.47 7.51e-20 Initial pursuit acceleration; CRC cis rs853679 0.550 rs1150689 chr6:28165099 T/C cg12273811 chr6:28175739 NA 0.76 10.93 0.52 6.19e-24 Depression; CRC cis rs9309473 1.000 rs7580825 chr2:73635148 G/A cg20560298 chr2:73613845 ALMS1 -0.48 -6.03 -0.32 4.39e-9 Metabolite levels; CRC cis rs853679 0.517 rs4713145 chr6:28106827 T/C cg02631126 chr6:28058918 ZSCAN12L1 0.29 5.89 0.31 9.41e-9 Depression; CRC cis rs798766 1.000 rs11732213 chr4:1704244 T/C cg05874882 chr4:1763078 NA 0.38 6.44 0.33 4.16e-10 Bladder cancer;Urinary bladder cancer; CRC trans rs11654801 0.755 rs11650623 chr17:20859620 G/A cg23759823 chr7:139672531 TBXAS1 -0.39 -6.33 -0.33 8.17e-10 Mosquito bite size; CRC trans rs9650657 0.645 rs9969657 chr8:10515278 A/G cg06636001 chr8:8085503 FLJ10661 0.43 6.61 0.34 1.53e-10 Neuroticism; CRC cis rs4073416 0.504 rs6573612 chr14:65912829 G/A cg03016385 chr14:66212404 NA -0.42 -5.76 -0.3 1.95e-8 N-glycan levels; CRC cis rs898097 0.841 rs9896263 chr17:80902741 A/G cg17346650 chr17:80929145 B3GNTL1 0.35 5.63 0.3 3.92e-8 Breast cancer; CRC cis rs2404602 0.622 rs1567671 chr15:77209200 C/G cg03037974 chr15:76606532 NA -0.52 -6.94 -0.36 2.07e-11 Blood metabolite levels; CRC cis rs7786808 0.778 rs34212455 chr7:158224490 C/T cg15440763 chr7:158190612 PTPRN2 0.42 6.5 0.34 2.94e-10 Obesity-related traits; CRC cis rs2933343 0.700 rs789239 chr3:128633808 T/C cg11901034 chr3:128598214 ACAD9 -0.56 -8.13 -0.41 9.06e-15 IgG glycosylation; CRC trans rs61931739 0.500 rs10844845 chr12:34381117 C/T cg13010199 chr12:38710504 ALG10B 0.44 6.29 0.33 9.85e-10 Morning vs. evening chronotype; CRC cis rs7618915 0.547 rs62255362 chr3:52699741 C/G cg15147215 chr3:52552868 STAB1 -0.63 -10.4 -0.5 4.44e-22 Bipolar disorder; CRC cis rs1499614 1.000 rs2659911 chr7:66158420 G/A cg12463550 chr7:65579703 CRCP 0.64 5.79 0.3 1.66e-8 Gout; CRC cis rs11122272 0.735 rs2749699 chr1:231520279 A/C cg06096015 chr1:231504339 EGLN1 0.4 5.94 0.31 7.17e-9 Hemoglobin concentration; CRC cis rs250677 0.917 rs36066 chr5:148419771 A/G cg23229984 chr5:148520753 ABLIM3 0.51 7.06 0.36 1.02e-11 Breast cancer; CRC cis rs56114371 0.777 rs200482 chr6:27773904 G/A cg19041857 chr6:27730383 NA -0.73 -7.16 -0.37 5.2e-12 Breast cancer; CRC cis rs4664293 0.647 rs10196064 chr2:160425965 G/A cg08347373 chr2:160653686 CD302 -0.39 -6.59 -0.34 1.76e-10 Monocyte percentage of white cells; CRC cis rs734999 0.566 rs10752747 chr1:2524915 G/T cg20673091 chr1:2541236 MMEL1 0.37 6.03 0.32 4.48e-9 Ulcerative colitis; CRC cis rs637571 0.522 rs566590 chr11:65754062 C/T cg26695010 chr11:65641043 EFEMP2 -0.4 -6.07 -0.32 3.5e-9 Eosinophil percentage of white cells; CRC trans rs7618501 1.000 rs9859153 chr3:49807085 G/T cg21665057 chr3:196295764 WDR53;FBXO45 0.86 15.78 0.66 3.53e-42 Intelligence (multi-trait analysis); CRC cis rs977987 0.836 rs7198873 chr16:75474754 G/A cg03315344 chr16:75512273 CHST6 0.55 9.34 0.46 1.5e-18 Dupuytren's disease; CRC cis rs1707322 0.752 rs11488313 chr1:46224780 G/C cg03146154 chr1:46216737 IPP 0.65 9.33 0.46 1.59e-18 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs617791 0.530 rs7934543 chr11:65752508 G/T cg27068330 chr11:65405492 SIPA1 -0.46 -6.31 -0.33 9.09e-10 Breast cancer; CRC cis rs10463316 0.894 rs7727926 chr5:150767216 G/A cg03212797 chr5:150827313 SLC36A1 -0.5 -7.85 -0.4 6.1e-14 Metabolite levels (Pyroglutamine); CRC cis rs637571 0.726 rs526631 chr11:65681965 T/G cg26695010 chr11:65641043 EFEMP2 0.45 6.88 0.35 3.08e-11 Eosinophil percentage of white cells; CRC cis rs6500395 1.000 rs2883475 chr16:48560315 C/T cg04672837 chr16:48644449 N4BP1 0.42 6.02 0.31 4.69e-9 Response to tocilizumab in rheumatoid arthritis; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg19012731 chr7:86688923 KIAA1324L 0.41 7.58 0.39 3.63e-13 Liver disease severity in Alagille syndrome; CRC cis rs2836974 0.897 rs12481860 chr21:40537836 T/A cg11644478 chr21:40555479 PSMG1 0.81 12.73 0.57 1.92e-30 Cognitive function; CRC cis rs7731657 0.537 rs2158352 chr5:130309465 A/G cg08523029 chr5:130500466 HINT1 0.45 5.66 0.3 3.38e-8 Fasting plasma glucose; CRC cis rs6598955 0.670 rs10794525 chr1:26537193 C/A cg00852783 chr1:26633632 UBXN11 0.46 7.37 0.38 1.43e-12 Obesity-related traits; CRC cis rs2404602 0.716 rs12437627 chr15:76845050 T/C cg22467129 chr15:76604101 ETFA -0.43 -7.35 -0.38 1.54e-12 Blood metabolite levels; CRC cis rs6500602 0.627 rs1641866 chr16:4593040 A/C cg06139259 chr16:4526053 HMOX2;NMRAL1 0.42 5.63 0.3 3.94e-8 Schizophrenia; CRC cis rs3796352 1.000 rs60942590 chr3:53016421 G/A cg27565382 chr3:53032988 SFMBT1 0.65 5.68 0.3 2.94e-8 Immune reponse to smallpox (secreted IL-2); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg26403198 chr8:145581686 FBXL6;GPR172A 0.44 5.99 0.31 5.65e-9 Response to antipsychotic treatment; CRC cis rs6461049 0.646 rs3778970 chr7:2143208 C/A cg02951883 chr7:2050386 MAD1L1 -0.67 -10.33 -0.49 7.59e-22 Schizophrenia; CRC cis rs10760158 0.739 rs4837819 chr9:124008434 A/G cg14417974 chr9:124058376 GSN -0.33 -5.6 -0.3 4.46e-8 Pulse pressure; CRC cis rs17826219 0.706 rs57698184 chr17:29064918 T/C cg01831904 chr17:28903510 LRRC37B2 -0.63 -6.47 -0.34 3.6e-10 Body mass index; CRC cis rs34375054 0.526 rs2343638 chr12:125677122 G/C cg05341575 chr12:125625032 AACS -0.38 -5.95 -0.31 6.79e-9 Post bronchodilator FEV1/FVC ratio; CRC cis rs4665809 1.000 rs4233710 chr2:26291565 G/A cg22920501 chr2:26401640 FAM59B -0.56 -7.27 -0.37 2.61e-12 Gut microbiome composition (summer); CRC cis rs35306767 0.903 rs12762228 chr10:880854 G/A cg26597838 chr10:835615 NA 1.26 14.66 0.63 8.53e-38 Eosinophil percentage of granulocytes; CRC trans rs7395662 0.525 rs1945189 chr11:48418889 A/G cg15704280 chr7:45808275 SEPT13 -0.49 -7.03 -0.36 1.18e-11 HDL cholesterol; CRC cis rs13256369 0.802 rs11249884 chr8:8561552 C/T cg17143192 chr8:8559678 CLDN23 -0.51 -6.58 -0.34 1.91e-10 Obesity-related traits; CRC cis rs7727544 0.716 rs72793278 chr5:131561372 C/A cg02033258 chr5:131593261 PDLIM4 0.36 6.78 0.35 5.69e-11 Blood metabolite levels; CRC cis rs9733 0.628 rs72700895 chr1:150626029 C/T cg18016565 chr1:150552671 MCL1 0.46 6.74 0.35 6.91e-11 Tonsillectomy; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg00352360 chr17:37009309 RPL23;SNORA21 0.47 6.12 0.32 2.64e-9 Thyroid stimulating hormone; CRC cis rs34779708 0.733 rs7081597 chr10:35546331 G/C cg03585969 chr10:35415529 CREM 0.52 6.86 0.35 3.39e-11 Inflammatory bowel disease;Crohn's disease; CRC cis rs9914988 0.887 rs4795456 chr17:27072463 G/A cg16670446 chr17:27188758 MIR451;MIR144 0.52 8.2 0.41 5.41e-15 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs2836950 0.565 rs3171465 chr21:40552307 A/G cg17971929 chr21:40555470 PSMG1 -0.58 -8.52 -0.43 5.91e-16 Menarche (age at onset); CRC cis rs7772486 0.875 rs2814875 chr6:146305810 G/A cg13319975 chr6:146136371 FBXO30 -0.4 -5.93 -0.31 7.7e-9 Lobe attachment (rater-scored or self-reported); CRC trans rs7618501 1.000 rs1049256 chr3:49763338 T/C cg21665057 chr3:196295764 WDR53;FBXO45 -0.85 -15.74 -0.66 5.05e-42 Intelligence (multi-trait analysis); CRC cis rs11212617 0.935 rs627418 chr11:108131225 T/C cg01991180 chr11:108092276 ATM;NPAT 0.4 5.83 0.31 1.33e-8 Response to metformin in type 2 diabetes (glycemic); CRC cis rs1153858 1.000 rs12440038 chr15:45706739 A/G cg10760299 chr15:45669010 GATM 0.51 7.74 0.39 1.25e-13 Homoarginine levels; CRC cis rs72615157 0.561 rs113844570 chr7:99873778 A/C cg19337854 chr7:99768885 GPC2 0.47 5.95 0.31 7e-9 Lung function (FEV1/FVC); CRC cis rs755249 0.529 rs3768299 chr1:39857192 C/T cg18385671 chr1:39797026 MACF1 -0.42 -6.05 -0.32 4.02e-9 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs780094 0.500 rs12464616 chr2:27827092 C/T cg27432699 chr2:27873401 GPN1 0.48 6.11 0.32 2.82e-9 Calcium levels;Fasting blood insulin;Metabolic traits;Triglyceride levels;Fasting plasma glucose;Urate levels in overweight individuals;Urate levels in obese individuals;Uric acid levels;Height;Age-related diseases, mortality and associated endophenotypes;Renal underexcretion gout;Fasting blood glucose (BMI interaction);Urate levels;Gondoic acid (20:1n-9) levels;Fasting blood insulin (BMI interaction);Triglycerides;Plasma omega-3 polyunsaturated fatty acid levels (docosapentaenoic acid);Type 2 diabetes;Nonalcoholic fatty liver disease;Hypertriglyceridemia;C-reactive protein;Age-related disease endophenotypes;LDL cholesterol;Metabolic syndrome;Crohn's disease;Alcohol consumption (drinks per week);Homeostasis model assessment of insulin resistance;Alcohol consumption;Red blood cell count;Fasting blood glucose; CRC cis rs9381040 0.610 rs4140580 chr6:41041742 C/T cg09580153 chr6:41068724 NFYA;LOC221442 -0.41 -5.9 -0.31 9.22e-9 Alzheimer's disease (late onset); CRC trans rs8108034 1.000 rs39587 chr19:39806997 C/T cg21249729 chr9:138392748 C9orf116;MRPS2 -0.54 -6.04 -0.32 4.28e-9 Lung adenocarcinoma; CRC trans rs7267979 1.000 rs6076345 chr20:25381895 T/G cg17903999 chr18:56338584 MALT1 0.42 6.93 0.36 2.17e-11 Liver enzyme levels (alkaline phosphatase); CRC cis rs57221529 0.766 rs72703065 chr5:588123 C/A cg14541582 chr5:601475 NA -0.37 -7.17 -0.37 5.13e-12 Lung disease severity in cystic fibrosis; CRC cis rs9372498 0.536 rs62422224 chr6:118941116 G/A cg24463073 chr6:118973353 C6orf204 0.51 6.47 0.34 3.56e-10 Diastolic blood pressure; CRC trans rs12478296 1.000 rs55758933 chr2:243040289 T/C cg18288967 chr1:45987694 PRDX1 0.68 7.48 0.38 6.93e-13 Obesity-related traits; CRC trans rs2303319 0.504 rs58622044 chr2:162596287 A/G cg20024234 chr21:43431083 ZNF295 -0.68 -6.17 -0.32 2.02e-9 Cognitive function; CRC cis rs11148252 0.532 rs9526975 chr13:53255804 C/T cg02158880 chr13:53174818 NA 0.65 10.08 0.49 5.47e-21 Lewy body disease; CRC cis rs447 0.583 rs6977516 chr7:83785834 T/G cg22846510 chr7:83753280 SEMA3A -0.43 -5.93 -0.31 7.83e-9 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg02056921 chr1:901892 PLEKHN1 0.5 7.4 0.38 1.13e-12 Response to antipsychotic treatment; CRC cis rs10504229 0.683 rs11786845 chr8:58133642 T/C cg02725872 chr8:58115012 NA -0.64 -11.39 -0.53 1.41e-25 Developmental language disorder (linguistic errors); CRC cis rs1030268 0.651 rs13222377 chr7:133466346 C/T cg03336402 chr7:133662267 EXOC4 -0.51 -5.62 -0.3 3.99e-8 Intelligence (multi-trait analysis); CRC cis rs6866614 0.608 rs17132288 chr5:131336105 C/T cg04518342 chr5:131593106 PDLIM4 0.33 5.75 0.3 2.03e-8 Perceived unattractiveness to mosquitoes; CRC cis rs9522267 0.535 rs11069897 chr13:112231319 A/G cg14352298 chr13:112236639 NA 0.3 6.71 0.35 8.5e-11 Hepatitis; CRC cis rs7731657 0.537 rs6595968 chr5:130284843 G/C cg08523029 chr5:130500466 HINT1 0.49 6.18 0.32 1.85e-9 Fasting plasma glucose; CRC cis rs10911232 0.507 rs10911196 chr1:182995233 G/A ch.1.3577855R chr1:183094577 LAMC1 0.87 15.17 0.64 8.94e-40 Hypertriglyceridemia; CRC cis rs2806561 0.796 rs1738467 chr1:23506521 C/T cg12483005 chr1:23474871 LUZP1 0.52 7.53 0.38 4.82e-13 Height; CRC cis rs7089973 0.604 rs7915943 chr10:116618077 G/A cg23260525 chr10:116636907 FAM160B1 0.36 8.51 0.42 6.43e-16 Bipolar disorder or attention deficit hyperactivity disorder; CRC trans rs7267979 0.932 rs2260997 chr20:25256266 A/C cg17903999 chr18:56338584 MALT1 0.4 6.51 0.34 2.74e-10 Liver enzyme levels (alkaline phosphatase); CRC cis rs2949837 0.528 rs10260816 chr7:46010100 C/G cg04727332 chr7:45960243 IGFBP3 -0.38 -5.86 -0.31 1.14e-8 Sitting height ratio; CRC cis rs992157 0.560 rs1514132 chr2:219084082 C/T cg04880052 chr2:219191631 PNKD -0.42 -6.63 -0.34 1.37e-10 Colorectal cancer; CRC cis rs12479064 0.724 rs62153852 chr2:99934713 C/T cg26064155 chr2:99771622 LIPT1;TSGA10 -0.64 -7.65 -0.39 2.27e-13 Chronic sinus infection; CRC trans rs10243593 0.673 rs773402 chr7:40073077 A/C cg13911576 chr9:84174038 NA -0.35 -6.05 -0.32 3.86e-9 Lymphocyte counts; CRC cis rs9814567 1.000 rs13059720 chr3:134242021 T/G cg06541857 chr3:134203789 ANAPC13;CEP63 0.4 5.82 0.31 1.38e-8 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs9393777 0.920 rs35869525 chr6:26946687 C/T cg16898833 chr6:26189333 HIST1H4D 0.87 6.41 0.33 5.05e-10 Intelligence (multi-trait analysis); CRC cis rs9549328 0.520 rs36144023 chr13:113616592 T/C cg25790453 chr13:113633590 MCF2L 0.43 7.55 0.38 4.25e-13 Systolic blood pressure; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg06456512 chr15:69113056 ANP32A 0.47 5.97 0.31 6.13e-9 Thyroid stimulating hormone; CRC trans rs6534347 0.788 rs2069763 chr4:123377482 C/A cg21129976 chr7:100421502 EPHB4 0.38 5.97 0.31 6.23e-9 Type 1 diabetes; CRC cis rs4718428 0.705 rs11028 chr7:66276217 T/C cg18252515 chr7:66147081 NA -0.52 -7.41 -0.38 1.07e-12 Corneal structure; CRC cis rs12325245 0.536 rs34129245 chr16:58588191 A/G cg01472538 chr16:58549086 SETD6 1.06 6.94 0.36 2.05e-11 Schizophrenia; CRC cis rs1009181 0.585 rs9379827 chr6:26153335 G/T cg13736514 chr6:26305472 NA -0.4 -5.97 -0.31 6e-9 Childhood ear infection; CRC trans rs6500957 0.920 rs17648524 chr16:7459683 C/G cg13786165 chr15:65477609 CLPX 0.45 6.58 0.34 1.87e-10 Spherical equivalent (joint analysis main effects and education interaction); CRC cis rs10504229 0.817 rs78138632 chr8:58191341 G/T cg22535103 chr8:58192502 C8orf71 -0.83 -8.92 -0.44 3.31e-17 Developmental language disorder (linguistic errors); CRC cis rs853679 0.766 rs9368561 chr6:28168343 C/T cg03623178 chr6:28175578 NA 0.88 7.31 0.37 2.1e-12 Depression; CRC cis rs853679 0.517 rs9380062 chr6:28137569 G/A cg15786705 chr6:28176104 NA 0.78 9.83 0.48 3.57e-20 Depression; CRC trans rs6762477 0.748 rs11717349 chr3:50223977 C/T cg21665057 chr3:196295764 WDR53;FBXO45 -0.43 -6.6 -0.34 1.66e-10 Menarche (age at onset); CRC cis rs7208859 0.673 rs999797 chr17:29159329 G/A cg01831904 chr17:28903510 LRRC37B2 -0.56 -5.86 -0.31 1.11e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs3806843 0.900 rs2563286 chr5:140125199 T/A cg19875535 chr5:140030758 IK -0.52 -8.48 -0.42 7.74e-16 Depressive symptoms (multi-trait analysis); CRC cis rs7487075 0.893 rs4547171 chr12:46733392 A/G cg22049899 chr12:47219821 SLC38A4 0.33 6.45 0.34 4e-10 Itch intensity from mosquito bite; CRC cis rs11122272 0.525 rs2739517 chr1:231537914 C/A cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.59 -8.89 -0.44 4.24e-17 Hemoglobin concentration; CRC cis rs6502050 0.787 rs11653012 chr17:80058857 C/T cg13198984 chr17:80129470 CCDC57 -0.39 -6.76 -0.35 6.14e-11 Life satisfaction; CRC cis rs7772486 0.875 rs9399573 chr6:146403255 A/T cg13319975 chr6:146136371 FBXO30 -0.39 -6.01 -0.31 4.96e-9 Lobe attachment (rater-scored or self-reported); CRC trans rs66573146 0.831 rs6851488 chr4:6987412 C/T cg07817883 chr1:32538562 TMEM39B 1.25 12.64 0.57 3.92e-30 Granulocyte percentage of myeloid white cells; CRC cis rs3733585 0.605 rs4697710 chr4:10122649 T/C cg00071950 chr4:10020882 SLC2A9 -0.56 -8.81 -0.44 7.1e-17 Cleft plate (environmental tobacco smoke interaction); CRC cis rs12594515 1.000 rs6493169 chr15:45986994 A/G cg22117107 chr15:45993392 NA 0.46 9.37 0.46 1.22e-18 Waist circumference;Weight; CRC cis rs13161895 1.000 rs13161895 chr5:179471201 C/T cg02702477 chr5:179499311 RNF130 0.55 6.26 0.33 1.18e-9 LDL cholesterol; CRC cis rs801193 0.660 rs10950049 chr7:66230860 T/C cg12463550 chr7:65579703 CRCP 0.46 6.34 0.33 7.75e-10 Aortic root size; CRC cis rs13217239 0.572 rs9379958 chr6:27066163 A/C cg12292205 chr6:26970375 C6orf41 -0.53 -8.69 -0.43 1.75e-16 Schizophrenia; CRC trans rs1005277 0.579 rs2472173 chr10:38374638 G/A cg23533926 chr12:111358616 MYL2 -0.52 -7.85 -0.4 6.09e-14 Extrinsic epigenetic age acceleration; CRC cis rs2739330 0.828 rs5751770 chr22:24252842 A/G cg16132339 chr22:24313637 DDTL;DDT 0.65 10.56 0.5 1.2e-22 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs6500602 0.893 rs6500598 chr16:4470964 G/T cg14951292 chr16:4525986 HMOX2;NMRAL1 0.57 7.52 0.38 5.31e-13 Schizophrenia; CRC cis rs752010 0.871 rs10890149 chr1:42092791 T/A cg06885757 chr1:42089581 HIVEP3 0.35 6.16 0.32 2.11e-9 Lupus nephritis in systemic lupus erythematosus; CRC cis rs4664293 1.000 rs4665083 chr2:160430127 C/T cg08347373 chr2:160653686 CD302 0.45 7.42 0.38 1e-12 Monocyte percentage of white cells; CRC trans rs1814175 0.647 rs1404157 chr11:49917301 G/C cg21153622 chr11:89784906 NA -0.43 -7.04 -0.36 1.12e-11 Height; CRC cis rs3126085 0.935 rs1390487 chr1:152194601 G/A cg09127314 chr1:152161683 NA 0.5 6.32 0.33 8.28e-10 Atopic dermatitis; CRC cis rs7945718 0.967 rs1440286 chr11:12809152 G/A cg25843174 chr11:12811716 TEAD1 0.48 9.25 0.45 2.82e-18 Educational attainment (years of education); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg17076921 chr10:75634595 CAMK2G 0.49 7.12 0.37 6.77e-12 Response to antipsychotic treatment; CRC trans rs4927850 0.881 rs7630489 chr3:195753401 T/C cg16724585 chr3:197361211 NA -0.48 -7.08 -0.36 8.94e-12 Pancreatic cancer; CRC cis rs10779751 1.000 rs7544489 chr1:11299511 A/G cg08854313 chr1:11322531 MTOR -0.77 -12.12 -0.56 3.36e-28 Body mass index; CRC cis rs6860806 0.507 rs2631362 chr5:131707293 A/G cg24060327 chr5:131705240 SLC22A5 0.56 8.39 0.42 1.46e-15 Breast cancer; CRC cis rs66782572 1 rs66782572 chr3:52567617 A/G cg08222913 chr3:52553049 STAB1 -0.42 -8.57 -0.43 4.18e-16 Hemoglobin concentration; CRC cis rs7552404 0.924 rs1694419 chr1:76219801 C/T cg22875332 chr1:76189707 ACADM 0.69 10.9 0.51 8.22e-24 Blood metabolite levels;Acylcarnitine levels; CRC trans rs208520 0.690 rs74707865 chr6:66717352 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 1.05 14.77 0.63 3.05e-38 Exhaled nitric oxide output; CRC cis rs394563 0.591 rs237018 chr6:149743930 A/G cg07828024 chr6:149772892 ZC3H12D -0.5 -9.52 -0.46 3.84e-19 Dupuytren's disease; CRC cis rs9914988 0.887 rs62066838 chr17:27184533 C/T cg20469991 chr17:27169893 C17orf63 0.48 5.9 0.31 8.83e-9 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs4731207 0.698 rs10954049 chr7:124535450 G/A cg23710748 chr7:124431027 NA -0.38 -6.06 -0.32 3.65e-9 Cutaneous malignant melanoma; CRC cis rs2204008 0.591 rs11495396 chr12:38380182 C/T cg26384229 chr12:38710491 ALG10B 0.69 9.77 0.47 5.95e-20 Bladder cancer; CRC cis rs9326248 0.813 rs588534 chr11:117068504 A/G cg26566898 chr11:117069891 TAGLN 0.39 6.96 0.36 1.8e-11 Blood protein levels; CRC cis rs951366 0.903 rs823114 chr1:205719532 G/A cg07157834 chr1:205819609 PM20D1 0.46 6.84 0.35 3.79e-11 Menarche (age at onset); CRC cis rs7100689 0.784 rs4934153 chr10:82191255 T/C cg00277334 chr10:82204260 NA -0.46 -6.04 -0.32 4.13e-9 Post bronchodilator FEV1; CRC cis rs7474896 0.616 rs2505239 chr10:38440765 A/G cg25427524 chr10:38739819 LOC399744 -0.52 -5.78 -0.3 1.72e-8 Obesity (extreme); CRC cis rs763014 0.966 rs7185390 chr16:666382 A/G cg08989290 chr16:615782 NHLRC4 0.45 8.7 0.43 1.61e-16 Height; CRC cis rs34779708 0.897 rs9665538 chr10:35461038 T/C cg03585969 chr10:35415529 CREM 0.55 7.4 0.38 1.18e-12 Inflammatory bowel disease;Crohn's disease; CRC cis rs7044106 0.708 rs2416760 chr9:123374639 T/C cg14255062 chr9:123606675 PSMD5;LOC253039 0.41 6.24 0.33 1.36e-9 Hip circumference adjusted for BMI; CRC cis rs10782582 0.609 rs1796827 chr1:76391536 A/T cg10523679 chr1:76189770 ACADM -0.39 -5.62 -0.3 4.18e-8 Daytime sleep phenotypes; CRC cis rs7249142 0.597 rs759999 chr19:19281207 A/C cg26504305 chr19:19281019 LOC729991-MEF2B;MEF2B -0.42 -8.45 -0.42 9.57e-16 IgG glycosylation; CRC cis rs13118159 0.509 rs1882098 chr4:1352431 T/C cg02475777 chr4:1388615 CRIPAK 0.5 6.42 0.33 4.84e-10 Longevity; CRC cis rs2243480 0.908 rs55876148 chr7:65379800 G/A cg18252515 chr7:66147081 NA -1.1 -12.69 -0.57 2.71e-30 Diabetic kidney disease; CRC trans rs61931739 0.500 rs7977186 chr12:34431486 C/G cg26384229 chr12:38710491 ALG10B 0.65 8.57 0.43 4.12e-16 Morning vs. evening chronotype; CRC cis rs10751667 0.666 rs7396677 chr11:958878 C/T cg06064525 chr11:970664 AP2A2 -0.3 -6.21 -0.32 1.58e-9 Alzheimer's disease (late onset); CRC cis rs10760158 0.769 rs10818517 chr9:124004599 A/T cg14417974 chr9:124058376 GSN -0.33 -5.61 -0.3 4.2e-8 Pulse pressure; CRC trans rs10838798 0.501 rs2270994 chr11:48157869 T/C cg21153622 chr11:89784906 NA -0.44 -6.72 -0.35 7.83e-11 Height; CRC cis rs853679 0.517 rs3757185 chr6:28107776 T/A cg02631126 chr6:28058918 ZSCAN12L1 0.29 5.89 0.31 9.41e-9 Depression; CRC cis rs8141797 0.901 rs8138467 chr22:24458096 A/G cg20894457 chr22:24584366 SUSD2 -0.64 -6.73 -0.35 7.58e-11 Amyotrophic lateral sclerosis;Coronary artery disease; CRC cis rs8020095 0.571 rs8003929 chr14:67533273 C/G cg00791868 chr14:66963628 C14orf53 0.5 7.0 0.36 1.46e-11 Depression (quantitative trait); CRC trans rs1864585 0.520 rs73208790 chr8:10680025 T/A cg26278703 chr11:58910052 FAM111A 0.56 6.5 0.34 2.94e-10 Neutrophil percentage of white cells;Lymphocyte percentage of white cells; CRC cis rs6088590 0.931 rs12625149 chr20:33425812 A/C cg24642439 chr20:33292090 TP53INP2 -0.49 -8.34 -0.42 2.09e-15 Coronary artery disease; CRC cis rs853679 0.517 rs4713141 chr6:28101678 G/C cg12963246 chr6:28129442 ZNF389 0.49 5.78 0.3 1.73e-8 Depression; CRC cis rs11809207 0.523 rs2783626 chr1:26501044 C/T cg00147160 chr1:26503991 CNKSR1 -0.29 -6.05 -0.32 3.88e-9 Height; CRC cis rs6761276 0.899 rs13389457 chr2:113834885 T/C cg24553058 chr2:113831203 IL1F10 0.4 6.44 0.33 4.26e-10 Protein quantitative trait loci; CRC cis rs7258465 1.000 rs2303695 chr19:18562624 C/T cg10790698 chr19:18539756 SSBP4 -0.44 -8.39 -0.42 1.46e-15 Breast cancer; CRC cis rs9929218 0.551 rs6499193 chr16:68727069 C/T cg01251360 chr16:68772225 CDH1 -0.23 -5.69 -0.3 2.81e-8 Colorectal cancer; CRC cis rs4481887 0.741 rs7540715 chr1:248544206 C/T cg00666640 chr1:248458726 OR2T12 0.4 7.28 0.37 2.49e-12 Common traits (Other); CRC cis rs1153858 1.000 rs4271549 chr15:45652730 G/A cg10760299 chr15:45669010 GATM 0.52 8.37 0.42 1.66e-15 Homoarginine levels; CRC cis rs7552404 1.000 rs11161511 chr1:76210477 A/G cg03433033 chr1:76189801 ACADM -0.77 -10.5 -0.5 2.01e-22 Blood metabolite levels;Acylcarnitine levels; CRC cis rs4819052 0.851 rs8133045 chr21:46658137 A/G cg02159808 chr21:46707872 POFUT2;LOC642852 0.49 6.41 0.33 5.19e-10 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs7618501 0.602 rs2240327 chr3:50113034 C/T cg24308560 chr3:49941425 MST1R -0.47 -7.54 -0.38 4.47e-13 Intelligence (multi-trait analysis); CRC cis rs9916302 0.706 rs7208487 chr17:37543449 T/G cg15445000 chr17:37608096 MED1 -0.35 -6.23 -0.32 1.43e-9 Glomerular filtration rate (creatinine); CRC cis rs270601 0.909 rs2569265 chr5:131704519 T/C cg02033258 chr5:131593261 PDLIM4 -0.38 -6.37 -0.33 6.28e-10 Acylcarnitine levels; CRC cis rs13256369 1.000 rs13256369 chr8:8577379 T/C cg18904891 chr8:8559673 CLDN23 0.51 7.07 0.36 9.53e-12 Obesity-related traits; CRC trans rs1814175 0.817 rs10128730 chr11:50023369 G/T cg11707556 chr5:10655725 ANKRD33B -0.43 -8.45 -0.42 9.43e-16 Height; CRC cis rs798766 1.000 rs798755 chr4:1720824 A/G cg05874882 chr4:1763078 NA -0.37 -7.03 -0.36 1.23e-11 Bladder cancer;Urinary bladder cancer; CRC cis rs2832191 0.671 rs73346699 chr21:30515529 C/T cg08807101 chr21:30365312 RNF160 -0.52 -7.18 -0.37 4.76e-12 Dental caries; CRC cis rs7312774 0.748 rs12308071 chr12:107314539 T/A cg16260113 chr12:107380972 MTERFD3 0.74 7.4 0.38 1.17e-12 Severe influenza A (H1N1) infection; CRC cis rs1552244 1.000 rs67134728 chr3:10151431 G/C cg13047869 chr3:10149882 C3orf24 0.57 7.76 0.39 1.08e-13 Alzheimer's disease; CRC cis rs7615952 0.576 rs2276726 chr3:125826287 C/G cg15145296 chr3:125709740 NA -0.48 -6.0 -0.31 5.29e-9 Blood pressure (smoking interaction); CRC trans rs2637266 0.622 rs4745816 chr10:78216814 C/T cg01717276 chr15:75949380 SNX33 -0.4 -6.05 -0.32 4e-9 Pulmonary function; CRC cis rs6500602 0.701 rs4786508 chr16:4568043 G/A cg13763550 chr16:4524223 NMRAL1;HMOX2 0.45 5.61 0.3 4.33e-8 Schizophrenia; CRC cis rs4689388 0.929 rs1046320 chr4:6304344 C/T cg14416269 chr4:6271139 WFS1 0.37 6.07 0.32 3.61e-9 Type 2 diabetes and other traits;Type 2 diabetes; CRC cis rs8077889 0.672 rs2106764 chr17:41852717 T/A cg25876840 chr17:41920477 NA 0.36 5.71 0.3 2.49e-8 Triglycerides; CRC cis rs6764363 0.527 rs12497412 chr3:278334 T/C cg02057681 chr3:285234 CHL1 0.42 7.22 0.37 3.62e-12 Sudden cardiac arrest; CRC cis rs7949030 0.626 rs61296092 chr11:62320838 T/C cg13298116 chr11:62369859 EML3;MTA2 0.62 11.09 0.52 1.65e-24 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; CRC cis rs172166 0.516 rs1225618 chr6:28129713 A/C cg21251018 chr6:28226885 NKAPL 0.57 9.97 0.48 1.24e-20 Cardiac Troponin-T levels; CRC cis rs116095464 0.558 rs10056628 chr5:279512 G/A cg22496380 chr5:211416 CCDC127 -0.97 -9.55 -0.47 3e-19 Breast cancer; CRC cis rs968567 0.705 rs174572 chr11:61598288 C/T cg19610905 chr11:61596333 FADS2 -0.42 -6.05 -0.32 3.93e-9 Blood metabolite levels;Rheumatoid arthritis;Vitiligo;Glycerophospholipid levels; CRC cis rs9467711 0.659 rs36162392 chr6:26569135 T/C cg16898833 chr6:26189333 HIST1H4D 1.15 8.49 0.42 7.38e-16 Autism spectrum disorder or schizophrenia; CRC cis rs372883 0.564 rs766928 chr21:30753606 A/G cg24692254 chr21:30365293 RNF160 0.59 8.97 0.44 2.25e-17 Pancreatic cancer; CRC cis rs11677416 1.000 rs1304037 chr2:113532236 C/T cg06156847 chr2:113672199 IL1F7 0.42 6.44 0.33 4.16e-10 Response to antipsychotic treatment in schizophrenia (working memory); CRC trans rs9528384 0.711 rs34645729 chr13:62255080 A/C cg08375866 chr1:50799151 NA -0.32 -6.04 -0.32 4.17e-9 Verbal declarative memory; CRC cis rs6502050 0.835 rs12600852 chr17:80104593 G/A cg22110888 chr17:80059540 CCDC57 0.4 6.44 0.33 4.17e-10 Life satisfaction; CRC cis rs709400 0.663 rs62007687 chr14:103903763 G/T cg12935359 chr14:103987150 CKB -0.51 -7.85 -0.4 5.78e-14 Body mass index; CRC cis rs7618915 0.570 rs13068293 chr3:52672167 C/A cg18099408 chr3:52552593 STAB1 -0.43 -7.08 -0.36 8.86e-12 Bipolar disorder; CRC cis rs3996993 0.780 rs4317409 chr6:52694489 G/A cg20803780 chr6:52668592 GSTA1 0.36 6.44 0.33 4.25e-10 Hemoglobin concentration; CRC cis rs6712932 1.000 rs10170234 chr2:105841841 C/G cg27422857 chr2:105853526 NA -0.35 -6.54 -0.34 2.39e-10 Type 2 diabetes; CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg12738349 chr22:24236284 MIF 0.4 6.59 0.34 1.73e-10 Obesity-related traits; CRC cis rs6693567 0.545 rs2133129 chr1:150355537 T/C cg04165759 chr1:150448943 RPRD2 0.36 5.91 0.31 8.34e-9 Migraine; CRC cis rs8180040 0.966 rs11705957 chr3:47443262 T/G cg27129171 chr3:47204927 SETD2 -0.6 -9.37 -0.46 1.19e-18 Colorectal cancer; CRC cis rs9435341 1.000 rs1762484 chr1:107613923 A/C cg09367891 chr1:107599246 PRMT6 -0.69 -10.35 -0.5 6.19e-22 Facial morphology (factor 21, depth of nasal alae); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg25970082 chr1:119683285 WARS2 0.47 6.63 0.34 1.39e-10 Response to antipsychotic treatment; CRC cis rs6460942 0.630 rs17671056 chr7:12390961 C/G cg06484146 chr7:12443880 VWDE -0.61 -6.32 -0.33 8.52e-10 Coronary artery disease; CRC cis rs35306767 0.633 rs17221491 chr10:1065191 A/G cg20503657 chr10:835505 NA 0.88 10.35 0.5 6.2e-22 Eosinophil percentage of granulocytes; CRC trans rs7615952 0.576 rs4646763 chr3:125822129 G/A cg07211511 chr3:129823064 LOC729375 -0.69 -9.09 -0.45 9.31e-18 Blood pressure (smoking interaction); CRC cis rs3741404 0.791 rs7112960 chr11:63907079 A/G cg06219103 chr11:63990595 FERMT3 -0.38 -5.73 -0.3 2.29e-8 Platelet count; CRC cis rs28386778 0.897 rs7222189 chr17:61836372 T/C cg22520471 chr17:61851767 DDX42;CCDC47 0.74 11.62 0.54 2.25e-26 Prudent dietary pattern; CRC cis rs3768617 0.510 rs3768619 chr1:183092404 C/G ch.1.3577855R chr1:183094577 LAMC1 0.89 15.86 0.66 1.84e-42 Fuchs's corneal dystrophy; CRC cis rs282587 0.569 rs447717 chr13:113415038 A/G cg04656015 chr13:113407548 ATP11A 0.62 8.04 0.41 1.61e-14 Glycated hemoglobin levels; CRC cis rs9814567 1.000 rs1357762 chr3:134264859 A/C cg06541857 chr3:134203789 ANAPC13;CEP63 -0.38 -5.64 -0.3 3.64e-8 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs2836974 0.605 rs2836971 chr21:40652040 A/C cg11644478 chr21:40555479 PSMG1 -0.7 -11.4 -0.53 1.35e-25 Cognitive function; CRC cis rs2050392 0.517 rs7096279 chr10:30759608 C/T cg18806716 chr10:30721971 MAP3K8 -0.58 -8.29 -0.42 2.92e-15 Inflammatory bowel disease; CRC cis rs7264396 0.790 rs6058288 chr20:34228680 A/G cg04508476 chr20:34239394 CPNE1;RBM12 0.58 9.66 0.47 1.3e-19 Total cholesterol levels; CRC cis rs9303401 0.659 rs16943326 chr17:57050365 C/T cg10487724 chr17:56770010 TEX14;RAD51C 0.79 9.91 0.48 2.03e-20 Cognitive test performance; CRC cis rs2046867 0.908 rs11928067 chr3:72796340 T/C cg25664220 chr3:72788482 NA -0.45 -6.37 -0.33 6.33e-10 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; CRC cis rs4665809 0.590 rs4665318 chr2:26424517 C/T cg04944784 chr2:26401820 FAM59B 0.85 10.91 0.52 7.49e-24 Gut microbiome composition (summer); CRC cis rs1707322 0.752 rs28812624 chr1:46203736 T/A cg06784218 chr1:46089804 CCDC17 0.65 12.05 0.55 5.8e-28 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs10208940 0.920 rs10205573 chr2:68829419 A/T cg12452813 chr2:68675892 NA 0.48 6.0 0.31 5.29e-9 Urate levels in lean individuals; CRC cis rs4819052 0.851 rs1999334 chr21:46670457 A/G cg02159808 chr21:46707872 POFUT2;LOC642852 0.45 6.11 0.32 2.81e-9 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs9372498 0.505 rs9481789 chr6:118734320 A/C cg24463073 chr6:118973353 C6orf204 0.51 6.81 0.35 4.71e-11 Diastolic blood pressure; CRC cis rs10540 1.000 rs35898083 chr11:484469 C/T cg08200582 chr11:442649 ANO9 -0.7 -7.12 -0.37 6.8e-12 Body mass index; CRC cis rs6912958 0.559 rs451465 chr6:88043372 C/T cg08069147 chr6:88032118 GJB7;C6orf162 -0.7 -11.37 -0.53 1.72e-25 Monocyte percentage of white cells; CRC cis rs9807841 0.592 rs11085743 chr19:10759442 G/A cg17710535 chr19:10819994 QTRT1 0.43 6.27 0.33 1.11e-9 Inflammatory skin disease; CRC trans rs1814175 0.645 rs1722000 chr11:49917928 A/C cg03929089 chr4:120376271 NA -0.91 -16.07 -0.66 2.65e-43 Height; CRC trans rs931812 0.757 rs4734015 chr8:101909258 C/G cg20993868 chr7:22813445 NA 0.44 8.85 0.44 5.4e-17 Attention deficit hyperactivity disorder and conduct disorder; CRC cis rs13191362 0.935 rs35100164 chr6:162963003 T/C cg21926612 chr6:163149169 PACRG;PARK2 0.82 10.41 0.5 3.86e-22 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs17376456 0.569 rs7736892 chr5:93205597 G/A cg25358565 chr5:93447407 FAM172A -0.65 -7.6 -0.39 3.09e-13 Diabetic retinopathy; CRC cis rs2179367 0.959 rs564961 chr6:149657227 G/A cg11245181 chr6:149772854 ZC3H12D -0.4 -6.08 -0.32 3.4e-9 Dupuytren's disease; CRC cis rs11764590 0.715 rs11766468 chr7:2082604 G/A cg02421172 chr7:1938701 MAD1L1 0.46 6.07 0.32 3.56e-9 Neuroticism; CRC cis rs7215564 0.908 rs55886624 chr17:78658657 G/A cg09596252 chr17:78655493 RPTOR 0.53 5.66 0.3 3.26e-8 Myopia (pathological); CRC cis rs7959452 0.590 rs11177628 chr12:69765421 G/A cg14784868 chr12:69753453 YEATS4 0.85 15.01 0.64 3.63e-39 Blood protein levels; CRC trans rs10983614 1.000 rs7867776 chr9:120072627 A/G cg04919811 chr17:78870302 RPTOR 0.45 6.23 0.32 1.45e-9 Survival in pancreatic cancer; CRC cis rs1267303 0.642 rs1267301 chr1:46992853 C/G cg08533674 chr1:46993347 NA 0.82 10.42 0.5 3.66e-22 Monobrow; CRC trans rs7726839 0.540 rs72703092 chr5:599269 G/A cg11887960 chr12:57824829 NA 0.59 6.56 0.34 2.05e-10 Obesity-related traits; CRC cis rs1046896 0.739 rs28459016 chr17:80741194 G/A cg02711726 chr17:80685570 FN3KRP -0.57 -7.93 -0.4 3.52e-14 Glycated hemoglobin levels; CRC cis rs7949030 0.626 rs72927213 chr11:62351198 G/C cg11742103 chr11:62369870 EML3;MTA2 0.63 11.91 0.55 2.02e-27 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; CRC cis rs10206020 0.885 rs6746052 chr2:1576811 T/C cg26248373 chr2:1572462 NA -0.83 -12.33 -0.56 5.69e-29 IgG glycosylation; CRC cis rs2739330 0.731 rs5751792 chr22:24401542 G/A cg18538332 chr22:24372958 LOC391322 -0.64 -10.22 -0.49 1.71e-21 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs6793245 0.801 rs6781009 chr3:38585434 T/C cg01465620 chr3:38496096 LOC100128640;ACVR2B -0.48 -5.84 -0.31 1.24e-8 QT interval; CRC trans rs10983614 1.000 rs7867776 chr9:120072627 A/G cg05030077 chr16:2255199 MLST8 0.45 6.2 0.32 1.73e-9 Survival in pancreatic cancer; CRC cis rs7726839 0.540 rs72703095 chr5:601789 T/C cg09021430 chr5:549028 NA -0.73 -8.35 -0.42 1.96e-15 Obesity-related traits; CRC cis rs11971779 0.680 rs7808740 chr7:139028955 G/T cg07862535 chr7:139043722 LUC7L2 0.55 7.14 0.37 5.99e-12 Diisocyanate-induced asthma; CRC cis rs9914988 0.943 rs11651867 chr17:27147248 T/G cg20469991 chr17:27169893 C17orf63 -0.59 -7.19 -0.37 4.48e-12 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC trans rs561341 0.941 rs2470236 chr17:30304940 G/C cg20587970 chr11:113659929 NA -1.18 -17.29 -0.69 4.03e-48 Hip circumference adjusted for BMI; CRC cis rs763121 0.853 rs1065201 chr22:39069510 T/C cg06544989 chr22:39130855 UNC84B 0.45 6.9 0.36 2.7e-11 Menopause (age at onset); CRC cis rs6502050 0.835 rs7503189 chr17:80099486 C/A cg25804541 chr17:80189381 SLC16A3 -0.31 -5.97 -0.31 6.08e-9 Life satisfaction; CRC cis rs6570726 0.846 rs6914304 chr6:145921017 T/C cg13319975 chr6:146136371 FBXO30 -0.41 -6.0 -0.31 5.17e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs12928939 0.517 rs12934512 chr16:71965230 C/G cg03805757 chr16:71968109 PKD1L3 -0.6 -7.97 -0.4 2.63e-14 Post bronchodilator FEV1; CRC cis rs4713118 0.869 rs9283883 chr6:27715470 T/A cg03623178 chr6:28175578 NA 0.69 9.6 0.47 2.12e-19 Parkinson's disease; CRC cis rs870825 0.616 rs12502860 chr4:185636105 T/C cg04058563 chr4:185651563 MLF1IP 0.73 9.38 0.46 1.13e-18 Blood protein levels; CRC trans rs2303319 0.504 rs1006427 chr2:162592328 T/C cg03774468 chr3:140950104 ACPL2 -0.65 -6.07 -0.32 3.61e-9 Cognitive function; CRC cis rs7618915 0.547 rs11130323 chr3:52770277 T/C cg10802521 chr3:52805072 NEK4 -0.58 -8.92 -0.44 3.26e-17 Bipolar disorder; CRC cis rs6952808 0.792 rs2056481 chr7:1955435 A/G cg02951883 chr7:2050386 MAD1L1 -0.71 -11.2 -0.53 7.26e-25 Bipolar disorder and schizophrenia; CRC cis rs9487051 0.768 rs1269172 chr6:109522080 G/C cg01475377 chr6:109611718 NA -0.33 -5.79 -0.3 1.62e-8 Reticulocyte fraction of red cells; CRC trans rs7944735 0.767 rs1017875 chr11:47999218 C/T cg03929089 chr4:120376271 NA 0.56 6.43 0.33 4.42e-10 Intraocular pressure; CRC cis rs1552244 0.935 rs35148833 chr3:10116937 C/A cg16606324 chr3:10149918 C3orf24 0.72 9.82 0.48 3.92e-20 Alzheimer's disease; CRC cis rs11758351 0.866 rs56186759 chr6:26207181 C/T cg22723502 chr6:26240528 HIST1H4F -0.37 -6.21 -0.32 1.63e-9 Gout;Renal underexcretion gout; CRC trans rs11098499 0.818 rs12498599 chr4:120468503 C/T cg25214090 chr10:38739885 LOC399744 0.65 10.43 0.5 3.37e-22 Corneal astigmatism; CRC cis rs28386778 0.897 rs3785572 chr17:61829989 C/T cg22520471 chr17:61851767 DDX42;CCDC47 0.74 11.6 0.54 2.6e-26 Prudent dietary pattern; CRC cis rs9393777 0.841 rs67092078 chr6:27054772 G/A cg12315302 chr6:26189340 HIST1H4D 0.91 6.25 0.33 1.24e-9 Intelligence (multi-trait analysis); CRC cis rs10504229 0.596 rs7004566 chr8:58115602 G/C cg02725872 chr8:58115012 NA -0.64 -11.55 -0.54 3.85e-26 Developmental language disorder (linguistic errors); CRC cis rs9311474 0.569 rs7614981 chr3:52566914 G/T cg05573699 chr3:52720067 GNL3;PBRM1 -0.4 -6.17 -0.32 1.98e-9 Electroencephalogram traits; CRC cis rs524281 0.861 rs3953856 chr11:65965908 T/A cg16950941 chr11:66035639 RAB1B -0.62 -7.59 -0.39 3.28e-13 Electroencephalogram traits; CRC cis rs10174077 0.874 rs6750342 chr2:152485754 A/G cg06191203 chr2:152266755 RIF1 -0.59 -8.5 -0.42 6.89e-16 Squamous cell lung carcinoma; CRC cis rs10540 1.000 rs116876680 chr11:517473 G/T cg21784768 chr11:537496 LRRC56 -0.7 -6.63 -0.34 1.39e-10 Body mass index; CRC cis rs7618915 0.547 rs11130311 chr3:52675005 T/C cg18404041 chr3:52824283 ITIH1 -0.43 -8.82 -0.44 7.03e-17 Bipolar disorder; CRC cis rs6582630 0.519 rs4002440 chr12:38485012 A/G cg13010199 chr12:38710504 ALG10B 0.49 6.49 0.34 3.13e-10 Drug-induced liver injury (flucloxacillin); CRC cis rs6724607 0.875 rs9630991 chr2:191432139 G/A cg21644426 chr2:191273491 MFSD6 0.49 6.64 0.34 1.26e-10 Pulse pressure; CRC cis rs6460942 0.558 rs4330594 chr7:12278615 G/A cg06484146 chr7:12443880 VWDE -0.62 -6.5 -0.34 2.96e-10 Coronary artery disease; CRC trans rs3780486 0.813 rs3780488 chr9:33133812 T/C cg20290983 chr6:43655470 MRPS18A 1.15 25.04 0.81 3.26e-78 IgG glycosylation; CRC cis rs7412746 0.611 rs2271076 chr1:150916657 C/T cg17724175 chr1:150552817 MCL1 0.4 6.14 0.32 2.37e-9 Melanoma; CRC cis rs2243480 1.000 rs160637 chr7:65584318 C/T cg18252515 chr7:66147081 NA -1.18 -13.88 -0.61 8.21e-35 Diabetic kidney disease; CRC cis rs9467711 0.591 rs16891315 chr6:26111756 T/C cg08501292 chr6:25962987 TRIM38 0.6 6.03 0.32 4.4e-9 Autism spectrum disorder or schizophrenia; CRC cis rs12497850 0.765 rs12487580 chr3:49182932 G/A cg03060546 chr3:49711283 APEH 0.4 5.61 0.3 4.38e-8 Parkinson's disease; CRC trans rs9929218 0.954 rs1981871 chr16:68819007 C/T cg04657470 chr2:198365150 HSPE1;HSPD1 -0.8 -11.53 -0.54 4.75e-26 Colorectal cancer; CRC cis rs1552244 1.000 rs35993975 chr3:10067794 A/G cg02579736 chr3:10068473 FANCD2;CIDECP 1.06 12.37 0.56 4.19e-29 Alzheimer's disease; CRC cis rs34172651 0.917 rs200536 chr16:24749203 G/A cg00339695 chr16:24857497 SLC5A11 -0.26 -5.92 -0.31 8.03e-9 Intelligence (multi-trait analysis); CRC cis rs10782582 0.609 rs5745331 chr1:76273313 A/G cg03433033 chr1:76189801 ACADM -0.4 -5.69 -0.3 2.75e-8 Daytime sleep phenotypes; CRC cis rs9457247 0.967 rs377753 chr6:167389496 A/T cg23791538 chr6:167370224 RNASET2 -0.38 -5.97 -0.31 6.08e-9 Crohn's disease; CRC cis rs9287719 0.649 rs10186984 chr2:10734192 C/G cg00105475 chr2:10696890 NA -0.44 -6.93 -0.36 2.26e-11 Prostate cancer; CRC cis rs7503807 0.905 rs62068345 chr17:78608040 C/T cg09596252 chr17:78655493 RPTOR 0.41 6.5 0.34 2.95e-10 Obesity; CRC cis rs9916302 0.808 rs6503515 chr17:37606433 G/T cg15445000 chr17:37608096 MED1 0.43 9.47 0.46 5.76e-19 Glomerular filtration rate (creatinine); CRC cis rs703842 1.000 rs4646536 chr12:58157988 A/G cg00677455 chr12:58241039 CTDSP2 0.69 9.94 0.48 1.62e-20 Multiple sclerosis; CRC trans rs9858542 0.953 rs11711485 chr3:49491983 G/T cg21659725 chr3:3221576 CRBN -0.65 -8.82 -0.44 7.04e-17 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs3087591 0.960 rs1124918 chr17:29492423 A/G cg24425628 chr17:29625626 OMG;NF1 -0.82 -14.88 -0.63 1.23e-38 Hip circumference; CRC trans rs2243480 0.803 rs36127118 chr7:65565505 A/G cg10756647 chr7:56101905 PSPH 0.69 7.49 0.38 6.21e-13 Diabetic kidney disease; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg11954230 chr10:105677556 OBFC1 0.47 6.61 0.34 1.59e-10 Response to antipsychotic treatment; CRC cis rs9372498 0.536 rs9489436 chr6:118873817 A/C cg10217327 chr6:118973057 C6orf204 0.51 5.86 0.31 1.12e-8 Diastolic blood pressure; CRC cis rs73206853 0.841 rs11065631 chr12:110778383 A/G cg12870014 chr12:110450643 ANKRD13A 0.84 8.83 0.44 6.5e-17 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC cis rs938554 0.513 rs11943372 chr4:9999346 T/A cg00071950 chr4:10020882 SLC2A9 0.44 6.9 0.36 2.74e-11 Blood metabolite levels; CRC cis rs9976767 0.932 rs9981707 chr21:43827829 T/C cg23042151 chr21:43824109 UBASH3A -0.37 -6.44 -0.33 4.17e-10 Type 1 diabetes; CRC cis rs4919087 1.000 rs3740512 chr10:99078745 C/T cg25902810 chr10:99078978 FRAT1 0.4 6.12 0.32 2.65e-9 Monocyte count; CRC cis rs317689 0.690 rs317646 chr12:69657145 A/G cg20891283 chr12:69753455 YEATS4 -0.43 -5.74 -0.3 2.17e-8 Response to diuretic therapy; CRC trans rs4263408 0.934 rs9683743 chr4:39703194 A/C cg20735442 chr6:36390970 PXT1 -0.42 -6.37 -0.33 6.47e-10 Plasma amyloid beta peptide concentrations (ABx-40); CRC cis rs2243480 0.901 rs35087093 chr7:65405208 C/T cg12463550 chr7:65579703 CRCP 0.62 5.95 0.31 6.68e-9 Diabetic kidney disease; CRC cis rs1801251 1.000 rs6747645 chr2:233571033 C/T cg25237894 chr2:233734115 C2orf82 -0.5 -7.99 -0.4 2.34e-14 Coronary artery disease; CRC cis rs13108904 0.840 rs13149790 chr4:1262239 A/G cg19318889 chr4:1322082 MAEA 0.4 5.69 0.3 2.83e-8 Obesity-related traits; CRC cis rs4819052 0.851 rs1999334 chr21:46670457 A/G cg19498844 chr21:46707878 POFUT2;LOC642852 0.67 9.81 0.48 4.12e-20 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs870825 0.929 rs56106324 chr4:185589901 C/A cg07424746 chr4:185654737 MLF1IP -0.6 -5.84 -0.31 1.25e-8 Blood protein levels; CRC cis rs3820068 0.603 rs17448778 chr1:15985306 A/G cg27534772 chr1:16042836 PLEKHM2 0.53 10.63 0.51 6.82e-23 Systolic blood pressure; CRC cis rs910316 0.763 rs175057 chr14:75489632 C/T cg11812906 chr14:75593930 NEK9 -0.55 -8.38 -0.42 1.55e-15 Height; CRC cis rs9549328 0.614 rs34306822 chr13:113616499 G/A cg25790453 chr13:113633590 MCF2L 0.43 7.55 0.38 4.25e-13 Systolic blood pressure; CRC cis rs2070488 1.000 rs7433707 chr3:38443180 G/C cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.9 16.47 0.67 7.29e-45 Electrocardiographic conduction measures; CRC cis rs12541635 0.902 rs62525696 chr8:106968703 C/T cg10147462 chr8:107024639 NA 0.44 7.13 0.37 6.32e-12 Age of smoking initiation; CRC cis rs28386778 0.591 rs2584619 chr17:61913215 T/A cg22520471 chr17:61851767 DDX42;CCDC47 0.75 11.8 0.55 4.95e-27 Prudent dietary pattern; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg04531794 chr10:99609860 GOLGA7B 0.44 6.97 0.36 1.75e-11 Liver disease severity in Alagille syndrome; CRC cis rs453301 0.571 rs2929453 chr8:9084341 A/G cg06636001 chr8:8085503 FLJ10661 -0.57 -9.36 -0.46 1.28e-18 Joint mobility (Beighton score); CRC cis rs2949837 0.581 rs2960437 chr7:45977352 G/A cg21268650 chr7:45961089 IGFBP3 0.37 6.35 0.33 7e-10 Sitting height ratio; CRC cis rs28655083 1.000 rs1843457 chr16:77072400 T/C cg01753188 chr16:77233325 SYCE1L;MON1B -0.56 -7.95 -0.4 2.91e-14 Lobe attachment (rater-scored or self-reported); CRC cis rs7274811 0.652 rs291672 chr20:31951168 G/A cg07470512 chr20:32255052 NECAB3;C20orf134 0.43 5.89 0.31 9.32e-9 Height; CRC cis rs9925964 0.933 rs881929 chr16:31079371 G/T cg03418659 chr16:31128414 MYST1 0.47 6.73 0.35 7.64e-11 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs5769707 1.000 rs5769707 chr22:50013402 G/T cg05373962 chr22:49881684 NA -0.38 -7.41 -0.38 1.07e-12 Monocyte count;Monocyte percentage of white cells; CRC cis rs7811142 1.000 rs11766752 chr7:100073292 A/G cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.91 12.27 0.56 9.02e-29 Platelet count; CRC cis rs875971 1.000 rs6979382 chr7:65886375 C/T cg00343986 chr7:65444356 GUSB 0.42 6.14 0.32 2.39e-9 Aortic root size; CRC cis rs6088590 1.000 rs6119535 chr20:33442138 A/C cg24642439 chr20:33292090 TP53INP2 0.51 8.78 0.44 8.9e-17 Coronary artery disease; CRC cis rs9549367 0.789 rs12869947 chr13:113896156 A/G cg18105134 chr13:113819100 PROZ -0.75 -10.62 -0.51 7.54e-23 Platelet distribution width; CRC cis rs7412746 0.658 rs3843843 chr1:150918084 C/T cg10589385 chr1:150898437 SETDB1 0.32 6.86 0.35 3.37e-11 Melanoma; CRC cis rs13108904 0.846 rs3775100 chr4:1225106 T/C cg02018176 chr4:1364513 KIAA1530 0.39 6.56 0.34 2.12e-10 Obesity-related traits; CRC cis rs743757 0.938 rs2282753 chr3:50436716 C/T cg08207895 chr3:50388901 TUSC4;CYB561D2 0.45 6.6 0.34 1.61e-10 Diastolic blood pressure; CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg19877921 chr17:61904685 PSMC5;FTSJ3 0.39 6.23 0.32 1.44e-9 Obesity-related traits; CRC cis rs6460942 0.915 rs62448620 chr7:12458170 C/T cg20607287 chr7:12443886 VWDE -0.66 -6.93 -0.36 2.17e-11 Coronary artery disease; CRC cis rs9916302 0.904 rs2338797 chr17:37548241 G/A cg15445000 chr17:37608096 MED1 -0.43 -9.56 -0.47 2.78e-19 Glomerular filtration rate (creatinine); CRC cis rs7945718 0.775 rs10500759 chr11:12822588 A/G cg25843174 chr11:12811716 TEAD1 -0.48 -9.16 -0.45 5.67e-18 Educational attainment (years of education); CRC cis rs7618915 0.571 rs34115864 chr3:52612178 A/G cg11645453 chr3:52864694 ITIH4 0.35 6.11 0.32 2.81e-9 Bipolar disorder; CRC cis rs7412746 0.611 rs7556661 chr1:150892009 C/T cg17724175 chr1:150552817 MCL1 0.44 6.66 0.34 1.14e-10 Melanoma; CRC cis rs6062302 0.549 rs4809586 chr20:62249402 C/T cg06363034 chr20:62225388 GMEB2 -0.44 -6.82 -0.35 4.44e-11 Glioblastoma; CRC cis rs727505 0.721 rs67607629 chr7:124765867 C/T cg23710748 chr7:124431027 NA -0.63 -11.17 -0.52 8.96e-25 Lewy body disease; CRC cis rs7615952 0.599 rs2279821 chr3:125734308 G/A cg15145296 chr3:125709740 NA -0.58 -6.62 -0.34 1.45e-10 Blood pressure (smoking interaction); CRC cis rs6840360 0.642 rs10857260 chr4:152424056 C/G cg09659197 chr4:152720779 NA 0.33 6.48 0.34 3.37e-10 Intelligence (multi-trait analysis); CRC cis rs6502050 0.842 rs7218075 chr17:80076808 C/G cg19223190 chr17:80058835 NA -0.41 -6.56 -0.34 2.07e-10 Life satisfaction; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg03347828 chr17:7739579 NA 0.49 6.5 0.34 2.95e-10 Thyroid stimulating hormone; CRC cis rs7264396 0.673 rs2425163 chr20:34432670 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.6 -10.34 -0.5 6.84e-22 Total cholesterol levels; CRC cis rs7680126 0.633 rs4698014 chr4:10286301 C/T cg00071950 chr4:10020882 SLC2A9 -0.45 -5.99 -0.31 5.42e-9 Urate levels in lean individuals;Urate levels in overweight individuals;Urate levels in obese individuals; CRC cis rs7666738 1.000 rs35066600 chr4:98991066 C/A cg05340658 chr4:99064831 C4orf37 0.53 7.69 0.39 1.69e-13 Colonoscopy-negative controls vs population controls; CRC cis rs4072980 0.545 rs11210870 chr1:38449910 T/C cg17077180 chr1:38461687 NA -0.39 -6.0 -0.31 5.24e-9 Coronary artery disease; CRC cis rs58235267 0.553 rs1025132 chr2:63360639 G/A cg17519650 chr2:63277830 OTX1 0.47 6.75 0.35 6.78e-11 Prostate-specific antigen levels (conditioned on lead SNPs); CRC cis rs7412746 0.658 rs12090215 chr1:150893660 C/A cg10589385 chr1:150898437 SETDB1 0.32 6.88 0.35 3.04e-11 Melanoma; CRC cis rs1950626 0.743 rs12887333 chr14:101462612 C/A cg02351406 chr14:101447389 SNORD114-20;SNORD114-21 0.97 15.55 0.65 2.82e-41 Pelvic organ prolapse (moderate/severe); CRC cis rs11249608 0.510 rs6861539 chr5:178452307 A/G cg01312482 chr5:178451176 ZNF879 -0.35 -5.86 -0.31 1.1e-8 Pubertal anthropometrics; CRC cis rs8067354 0.645 rs2645491 chr17:57877049 C/T cg13753209 chr17:57696993 CLTC 0.44 5.81 0.3 1.49e-8 Hemoglobin concentration; CRC cis rs7737355 0.947 rs11744232 chr5:130911732 A/G cg25547332 chr5:131281432 NA 0.37 5.73 0.3 2.28e-8 Life satisfaction; CRC cis rs10046574 0.831 rs76054058 chr7:135093486 G/C cg27474649 chr7:135195673 CNOT4 0.69 5.71 0.3 2.58e-8 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs1475911 0.708 rs11701371 chr21:43523972 C/G cg14562523 chr21:43528734 C21orf128;UMODL1 -0.64 -9.86 -0.48 2.88e-20 IgG glycosylation; CRC cis rs1448094 0.511 rs61930588 chr12:86158991 A/G cg18827107 chr12:86230957 RASSF9 -0.38 -5.82 -0.31 1.37e-8 Major depressive disorder; CRC cis rs644799 0.965 rs11021313 chr11:95506907 G/C cg25478527 chr11:95522999 CEP57;FAM76B 0.52 7.75 0.39 1.15e-13 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs6973256 0.828 rs62471409 chr7:133371246 C/T cg10665199 chr7:133106180 EXOC4 -0.39 -5.86 -0.31 1.14e-8 Intelligence (multi-trait analysis); CRC cis rs1448094 0.512 rs4488288 chr12:86245450 A/C cg19622623 chr12:86230825 RASSF9 -0.41 -6.7 -0.35 9.04e-11 Major depressive disorder; CRC cis rs7727544 0.735 rs272879 chr5:131670546 C/G cg24060327 chr5:131705240 SLC22A5 -0.38 -6.23 -0.32 1.41e-9 Blood metabolite levels; CRC cis rs644799 0.526 rs693172 chr11:95636618 A/G cg03916912 chr11:95522834 CEP57;FAM76B 0.67 10.9 0.52 7.82e-24 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs3733585 0.673 rs10000983 chr4:9951606 T/C cg00071950 chr4:10020882 SLC2A9 -0.57 -10.12 -0.49 3.76e-21 Cleft plate (environmental tobacco smoke interaction); CRC cis rs2732480 0.500 rs1387257 chr12:48636666 C/A cg24011408 chr12:48396354 COL2A1 0.44 6.21 0.32 1.64e-9 Hemoglobin concentration;Red blood cell count;Hematocrit; CRC cis rs7552404 1.000 rs7534754 chr1:76185308 G/A cg10523679 chr1:76189770 ACADM 0.85 11.74 0.54 7.88e-27 Blood metabolite levels;Acylcarnitine levels; CRC cis rs9846480 0.598 rs6439806 chr3:138057203 G/A cg25476813 chr3:138050155 TXNDC6 -0.38 -5.66 -0.3 3.31e-8 Whole-brain volume (Alzheimer's disease interaction); CRC cis rs10979 0.964 rs12526234 chr6:143898680 A/T cg25407410 chr6:143891975 LOC285740 -0.85 -13.66 -0.6 5.96e-34 Hypospadias; CRC cis rs17253792 0.822 rs17253716 chr14:56153661 G/C cg01858014 chr14:56050164 KTN1 -0.87 -7.03 -0.36 1.17e-11 Putamen volume; CRC cis rs11098499 0.564 rs11098507 chr4:120288286 G/A cg24375607 chr4:120327624 NA 0.48 7.48 0.38 6.72e-13 Corneal astigmatism; CRC cis rs951366 0.789 rs7536483 chr1:205718858 A/T cg07157834 chr1:205819609 PM20D1 0.76 11.48 0.53 6.93e-26 Menarche (age at onset); CRC cis rs1448094 0.717 rs7298614 chr12:86296513 C/T cg19622623 chr12:86230825 RASSF9 -0.42 -6.86 -0.35 3.33e-11 Major depressive disorder; CRC cis rs9443645 0.670 rs79209669 chr6:79719623 C/G cg11833968 chr6:79620685 NA -0.35 -6.04 -0.32 4.19e-9 Intelligence (multi-trait analysis); CRC cis rs7615952 0.599 rs1044215 chr3:125725559 C/G cg02807482 chr3:125708958 NA -0.41 -5.72 -0.3 2.37e-8 Blood pressure (smoking interaction); CRC cis rs2011503 1.000 rs111406321 chr19:19637437 G/A cg11584989 chr19:19387371 SF4 0.58 6.48 0.34 3.27e-10 Bipolar disorder; CRC cis rs10256972 0.706 rs12701969 chr7:1121849 A/G cg22907277 chr7:1156413 C7orf50 0.66 9.65 0.47 1.42e-19 Longevity;Endometriosis; CRC cis rs449789 0.857 rs575681 chr6:159703534 G/A cg14500486 chr6:159655392 FNDC1 -0.48 -7.4 -0.38 1.13e-12 Pulse pressure; CRC trans rs7615952 0.866 rs11922276 chr3:125631326 G/T cg02560186 chr11:3602584 NA -0.46 -6.01 -0.31 4.79e-9 Blood pressure (smoking interaction); CRC trans rs35110281 0.667 rs4819288 chr21:45120173 C/G cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.44 6.96 0.36 1.86e-11 Mean corpuscular volume; CRC cis rs4713118 0.662 rs9468277 chr6:28028390 C/A cg06470822 chr6:28175283 NA 0.95 13.56 0.6 1.43e-33 Parkinson's disease; CRC cis rs4713118 0.588 rs200994 chr6:27813813 A/C cg06470822 chr6:28175283 NA -0.78 -10.3 -0.49 9.3e-22 Parkinson's disease; CRC cis rs6951245 0.744 rs10265758 chr7:1172518 C/T cg21664854 chr7:1097933 C7orf50;GPR146 0.68 8.27 0.41 3.43e-15 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs2239547 0.607 rs9836178 chr3:52925403 T/C cg18404041 chr3:52824283 ITIH1 0.34 6.23 0.32 1.41e-9 Schizophrenia; CRC trans rs9693857 0.520 rs11249928 chr8:9363260 T/C cg06636001 chr8:8085503 FLJ10661 0.46 6.09 0.32 3.23e-9 Systolic blood pressure; CRC cis rs4731207 0.596 rs6466988 chr7:124678116 G/A cg23710748 chr7:124431027 NA -0.39 -6.18 -0.32 1.94e-9 Cutaneous malignant melanoma; CRC cis rs13082711 0.954 rs67282221 chr3:27552752 T/A cg02860705 chr3:27208620 NA 0.58 7.43 0.38 9.49e-13 Systolic blood pressure;Diastolic blood pressure;Blood pressure; CRC cis rs2075371 0.932 rs2241333 chr7:133970750 C/T cg02659138 chr7:134003124 SLC35B4 0.34 5.94 0.31 7.32e-9 Mean platelet volume; CRC cis rs7727544 0.735 rs270605 chr5:131651811 C/T cg24060327 chr5:131705240 SLC22A5 -0.37 -5.88 -0.31 1.01e-8 Blood metabolite levels; CRC cis rs6951245 1.000 rs75488469 chr7:1102122 A/G cg04025307 chr7:1156635 C7orf50 0.64 6.84 0.35 3.87e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs7487637 0.529 rs11168245 chr12:48204499 C/G cg14736327 chr12:48174669 SLC48A1 -0.6 -7.68 -0.39 1.85e-13 Mononucleosis; CRC cis rs2439831 0.867 rs2470134 chr15:43849886 A/G cg02155558 chr15:43621948 ADAL;LCMT2 -0.68 -7.52 -0.38 5.26e-13 Lung cancer in ever smokers; CRC trans rs12517041 1.000 rs2081952 chr5:23295605 A/G ch.8.1293020R chr8:59333349 UBXN2B -0.55 -6.17 -0.32 2.05e-9 Calcium levels; CRC cis rs7917772 0.503 rs7087665 chr10:104282418 T/C cg04362960 chr10:104952993 NT5C2 -0.42 -5.9 -0.31 8.92e-9 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC cis rs7811142 0.830 rs77861211 chr7:99962096 T/C cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.61 7.95 0.4 3e-14 Platelet count; CRC cis rs1707322 0.821 rs10749857 chr1:46248143 C/T cg06784218 chr1:46089804 CCDC17 0.6 10.75 0.51 2.58e-23 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs55675132 0.510 rs10489526 chr1:115293527 C/A cg12756093 chr1:115239321 AMPD1 0.52 6.24 0.33 1.34e-9 Schizophrenia; CRC trans rs7819412 0.775 rs11773990 chr8:10935082 T/C cg06636001 chr8:8085503 FLJ10661 -0.61 -9.06 -0.45 1.19e-17 Triglycerides; CRC cis rs826838 0.967 rs1684415 chr12:39130099 T/C cg13010199 chr12:38710504 ALG10B -0.41 -5.84 -0.31 1.27e-8 Heart rate; CRC cis rs2304069 0.565 rs13183261 chr5:149421847 T/G cg22760475 chr5:149380129 HMGXB3;TIGD6 0.44 6.43 0.33 4.47e-10 HIV-1 control; CRC cis rs4731207 0.596 rs1871776 chr7:124674648 A/G cg23710748 chr7:124431027 NA -0.4 -6.23 -0.33 1.39e-9 Cutaneous malignant melanoma; CRC cis rs17023223 0.537 rs12064137 chr1:119709749 G/A cg05756136 chr1:119680316 WARS2 -0.52 -7.14 -0.37 6e-12 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for BMI in active individuals; CRC cis rs853679 0.599 rs149990 chr6:27998258 G/A cg15786705 chr6:28176104 NA 0.67 6.36 0.33 6.67e-10 Depression; CRC cis rs6500602 0.767 rs8060219 chr16:4480158 T/A cg08645402 chr16:4508243 NA 0.55 9.0 0.44 1.82e-17 Schizophrenia; CRC cis rs4481887 0.893 rs10888349 chr1:248448625 T/C cg13385794 chr1:248469461 NA 0.37 6.43 0.33 4.61e-10 Common traits (Other); CRC cis rs7894407 0.856 rs7093667 chr10:105080575 T/C cg05636881 chr10:105038444 INA 0.36 5.8 0.3 1.59e-8 White matter hyperintensity burden; CRC trans rs1005277 0.579 rs2474584 chr10:38416389 C/T cg11292332 chr7:45801988 SEPT13 -0.35 -6.22 -0.32 1.47e-9 Extrinsic epigenetic age acceleration; CRC cis rs727505 0.520 rs1454125 chr7:124862733 C/T cg23710748 chr7:124431027 NA -0.62 -10.3 -0.49 9.36e-22 Lewy body disease; CRC cis rs2576037 0.796 rs2247221 chr18:44580082 C/T cg19077165 chr18:44547161 KATNAL2 0.42 6.55 0.34 2.27e-10 Personality dimensions; CRC cis rs9640161 0.742 rs2108852 chr7:150019628 T/C cg13722127 chr7:150037890 RARRES2 0.49 7.66 0.39 2.13e-13 Blood protein levels;Circulating chemerin levels; CRC cis rs2277425 0.755 rs2277424 chr13:111522420 A/G cg16032841 chr13:111522222 C13orf29 -0.73 -9.54 -0.47 3.33e-19 Sitting height ratio; CRC cis rs60843830 0.928 rs62114494 chr2:211317 C/T cg00108164 chr2:264199 ACP1;SH3YL1 0.61 9.32 0.46 1.7e-18 Spherical equivalent (joint analysis main effects and education interaction); CRC cis rs1712517 0.838 rs6584543 chr10:104997014 G/A cg05636881 chr10:105038444 INA -0.47 -8.42 -0.42 1.17e-15 Migraine; CRC trans rs916888 0.773 rs199448 chr17:44809001 A/G cg01341218 chr17:43662625 NA 0.97 10.48 0.5 2.24e-22 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs9325144 0.678 rs7315271 chr12:39164731 A/G cg26384229 chr12:38710491 ALG10B -0.42 -5.61 -0.3 4.34e-8 Morning vs. evening chronotype; CRC cis rs4819052 0.851 rs2838829 chr21:46664040 A/C cg02159808 chr21:46707872 POFUT2;LOC642852 0.5 6.63 0.34 1.38e-10 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC trans rs3733585 0.683 rs13112015 chr4:9933796 C/T cg26043149 chr18:55253948 FECH -0.52 -7.78 -0.39 9.57e-14 Cleft plate (environmental tobacco smoke interaction); CRC trans rs11989744 0.500 rs7844903 chr8:23568464 T/C cg03492747 chr16:86543808 FOXF1 -0.59 -10.49 -0.5 2.04e-22 Waist-hip ratio; CRC cis rs4629180 0.586 rs2048252 chr2:102138384 C/T cg01388757 chr2:102091195 RFX8 -0.35 -5.65 -0.3 3.53e-8 Chronic rhinosinusitis with nasal polyps; CRC cis rs17095355 1.000 rs55897175 chr10:111699190 C/T cg00817464 chr10:111662876 XPNPEP1 -0.62 -8.23 -0.41 4.54e-15 Biliary atresia; CRC cis rs79387448 0.745 rs17027341 chr2:103136559 A/G cg00507830 chr2:103233733 NA 0.49 5.65 0.3 3.56e-8 Gut microbiota (bacterial taxa); CRC trans rs6886261 1.000 rs10071791 chr5:43098119 T/C cg24995083 chr14:95787435 CLMN 0.79 6.08 0.32 3.34e-9 Conotruncal heart defects (inherited effects); CRC cis rs875971 1.000 rs778710 chr7:65854834 T/C cg18912574 chr7:65842487 NCRNA00174 0.36 6.18 0.32 1.88e-9 Aortic root size; CRC cis rs4743820 0.651 rs10114465 chr9:93936592 C/T cg14446406 chr9:93919335 NA 0.69 12.33 0.56 5.62e-29 Ulcerative colitis;Inflammatory bowel disease; CRC trans rs6833159 0.527 rs10939231 chr4:28829372 A/T cg25048357 chr11:118955763 HMBS -0.44 -6.2 -0.32 1.65e-9 Underweight status; CRC cis rs897984 0.609 rs4889609 chr16:31026427 A/G cg00531865 chr16:30841666 NA -0.46 -6.45 -0.33 4.09e-10 Dementia with Lewy bodies; CRC cis rs7811142 0.830 rs73401451 chr7:99981895 T/C cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.94 12.65 0.57 3.55e-30 Platelet count; CRC trans rs2055729 0.677 rs10098618 chr8:9741478 A/T cg06636001 chr8:8085503 FLJ10661 0.48 6.03 0.32 4.3e-9 Multiple myeloma (hyperdiploidy); CRC cis rs6684514 1.000 rs12134983 chr1:156290409 T/C cg16558208 chr1:156270281 VHLL 0.58 8.92 0.44 3.2e-17 Mean corpuscular hemoglobin concentration;Glycated hemoglobin levels; CRC cis rs905456 0.868 rs6770525 chr3:30747817 A/G cg06106510 chr3:30762233 NA 0.31 5.66 0.3 3.35e-8 Positive affect; CRC cis rs7809950 0.678 rs982447 chr7:106973534 T/C cg23024343 chr7:107201750 COG5 -0.7 -9.65 -0.47 1.47e-19 Coronary artery disease; CRC cis rs3741151 0.773 rs73542990 chr11:73134398 C/T cg17517138 chr11:73019481 ARHGEF17 0.92 7.7 0.39 1.63e-13 GIP levels in response to oral glucose tolerance test (120 minutes); CRC cis rs71403859 0.730 rs12922775 chr16:71584354 C/T cg08717414 chr16:71523259 ZNF19 -0.94 -9.18 -0.45 5.08e-18 Post bronchodilator FEV1; CRC cis rs2342371 0.756 rs12637868 chr3:196106754 G/A cg15048948 chr3:196158458 UBXN7 0.51 6.26 0.33 1.18e-9 Fat distribution (HIV); CRC trans rs10982213 0.830 rs2274163 chr9:117188714 C/T cg24847481 chr1:100435557 SLC35A3 0.36 5.97 0.31 6.3e-9 Interleukin-6 levels; CRC cis rs314370 0.951 rs12705095 chr7:100484381 T/G cg10426581 chr7:100472382 SRRT 0.62 7.06 0.36 9.92e-12 Resting heart rate; CRC cis rs1799949 1.000 rs8070085 chr17:41341984 C/T cg23758822 chr17:41437982 NA -0.76 -12.76 -0.58 1.43e-30 Menopause (age at onset); CRC cis rs6496667 0.954 rs7162211 chr15:90892585 G/C cg04176472 chr15:90893244 GABARAPL3 0.54 8.26 0.41 3.53e-15 Rheumatoid arthritis; CRC cis rs9976767 1.000 rs3761378 chr21:43832918 C/T cg23042151 chr21:43824109 UBASH3A 0.32 5.65 0.3 3.49e-8 Type 1 diabetes; CRC cis rs853679 0.628 rs9368560 chr6:28159960 T/C cg25164649 chr6:28176230 NA 0.78 10.49 0.5 2.18e-22 Depression; CRC cis rs172166 0.694 rs203893 chr6:28062066 C/A cg15845792 chr6:28175446 NA 0.79 11.65 0.54 1.65e-26 Cardiac Troponin-T levels; CRC trans rs10504229 1.000 rs77120900 chr8:58170368 C/T cg04077850 chr5:125800366 GRAMD3 0.37 6.27 0.33 1.15e-9 Developmental language disorder (linguistic errors); CRC cis rs2976388 0.609 rs2585140 chr8:143806896 A/G cg15511327 chr8:143859410 LYNX1 0.39 6.88 0.35 3.12e-11 Urinary tract infection frequency; CRC cis rs7927592 0.913 rs10896338 chr11:68299360 G/A cg01657329 chr11:68192670 LRP5 -0.46 -6.58 -0.34 1.89e-10 Total body bone mineral density; CRC cis rs4713118 0.824 rs2092075 chr6:27749330 G/C cg26587870 chr6:27730563 NA -0.45 -6.55 -0.34 2.18e-10 Parkinson's disease; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg10554839 chr10:27529782 ACBD5 0.46 7.67 0.39 1.99e-13 Liver disease severity in Alagille syndrome; CRC cis rs754466 1.000 rs56256440 chr10:79698207 A/G cg17075019 chr10:79541650 NA -0.72 -10.12 -0.49 4e-21 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs1707322 0.721 rs12091503 chr1:46107868 T/C cg06784218 chr1:46089804 CCDC17 0.66 12.54 0.57 9.25e-30 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs11148252 0.574 rs2038826 chr13:53280013 G/A cg02158880 chr13:53174818 NA 0.55 8.67 0.43 1.95e-16 Lewy body disease; CRC trans rs800082 0.698 rs800077 chr3:144349940 A/G cg24215973 chr2:240111563 HDAC4 -0.77 -10.45 -0.5 2.86e-22 Smoking behavior; CRC cis rs9322193 0.607 rs10457852 chr6:150201720 C/T cg13206674 chr6:150067644 NUP43 0.48 5.94 0.31 7.13e-9 Lung cancer; CRC cis rs780096 0.546 rs1060525 chr2:27635582 A/G cg27432699 chr2:27873401 GPN1 -0.47 -7.13 -0.37 6.41e-12 Total body bone mineral density; CRC trans rs6076960 0.652 rs6085467 chr20:6259004 T/C cg17788362 chr6:86352627 SYNCRIP 0.51 7.24 0.37 3.27e-12 Smooth-surface caries; CRC cis rs17095355 1.000 rs55728195 chr10:111715599 G/A cg00817464 chr10:111662876 XPNPEP1 -0.62 -8.34 -0.42 2.1e-15 Biliary atresia; CRC cis rs172166 0.561 rs149973 chr6:27983613 G/T cg02683197 chr6:28174875 NA 0.46 6.38 0.33 6.1e-10 Cardiac Troponin-T levels; CRC cis rs798554 0.797 rs798497 chr7:2795957 A/G cg14895029 chr7:2775587 GNA12 -0.46 -6.93 -0.36 2.19e-11 Height; CRC cis rs4689592 0.554 rs66925245 chr4:7071999 C/T cg19539972 chr4:7069911 GRPEL1 -0.85 -9.83 -0.48 3.74e-20 Monocyte percentage of white cells; CRC cis rs4073416 0.534 rs7147002 chr14:66032546 T/C cg03016385 chr14:66212404 NA -0.45 -6.19 -0.32 1.78e-9 N-glycan levels; CRC cis rs11098499 0.863 rs6853998 chr4:120475860 C/A cg09307838 chr4:120376055 NA 0.67 9.99 0.48 1.1e-20 Corneal astigmatism; CRC cis rs2070997 0.938 rs4740376 chr9:133747734 C/T cg01000188 chr9:133769184 QRFP 0.54 5.65 0.3 3.46e-8 Response to amphetamines; CRC cis rs4713118 0.539 rs200951 chr6:27835930 A/G cg02683197 chr6:28174875 NA 0.68 9.32 0.46 1.79e-18 Parkinson's disease; CRC cis rs3741404 0.825 rs7111753 chr11:63942189 A/G cg05016508 chr11:63871570 FLRT1;MACROD1 0.45 6.75 0.35 6.79e-11 Platelet count; CRC cis rs7726839 0.526 rs55647623 chr5:567747 T/C cg14541582 chr5:601475 NA -0.27 -5.88 -0.31 1e-8 Obesity-related traits; CRC cis rs6502050 0.835 rs4789666 chr17:80162276 C/T cg13198984 chr17:80129470 CCDC57 0.48 8.5 0.42 6.68e-16 Life satisfaction; CRC cis rs13256369 0.802 rs11249887 chr8:8562184 T/C cg06671706 chr8:8559999 CLDN23 0.61 9.05 0.45 1.3e-17 Obesity-related traits; CRC cis rs6424115 1.000 rs1018396 chr1:24133612 G/A cg15997130 chr1:24165203 NA 0.69 10.78 0.51 2.08e-23 Immature fraction of reticulocytes; CRC cis rs2811415 0.597 rs9819833 chr3:127793408 G/A cg13719885 chr3:127795394 NA -0.39 -5.86 -0.31 1.12e-8 Lung function (FEV1/FVC); CRC cis rs1552244 1.000 rs7615764 chr3:10082592 C/T cg00166722 chr3:10149974 C3orf24 0.71 9.49 0.46 4.86e-19 Alzheimer's disease; CRC cis rs11098499 0.954 rs1480931 chr4:120395809 G/T cg09307838 chr4:120376055 NA 0.69 10.92 0.52 6.88e-24 Corneal astigmatism; CRC cis rs7618915 0.533 rs35107891 chr3:52613656 G/C cg18404041 chr3:52824283 ITIH1 -0.43 -8.97 -0.44 2.23e-17 Bipolar disorder; CRC cis rs6502050 0.835 rs67634087 chr17:80118168 C/T cg25804541 chr17:80189381 SLC16A3 -0.32 -6.01 -0.31 5.04e-9 Life satisfaction; CRC cis rs71403859 0.502 rs17280181 chr16:71523514 C/T cg08717414 chr16:71523259 ZNF19 -1.0 -10.42 -0.5 3.76e-22 Post bronchodilator FEV1; CRC cis rs447 0.636 rs464 chr7:83786460 A/G cg22846510 chr7:83753280 SEMA3A -0.4 -5.66 -0.3 3.33e-8 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs9467711 0.591 rs35249036 chr6:26026163 C/G cg08501292 chr6:25962987 TRIM38 0.84 7.82 0.4 7.01e-14 Autism spectrum disorder or schizophrenia; CRC cis rs1403694 0.695 rs10439971 chr3:186434188 C/T cg04611788 chr3:186434169 KNG1 -0.61 -9.13 -0.45 7.33e-18 Blood protein levels; CRC cis rs11690935 0.918 rs11757 chr2:172641045 C/G cg13550731 chr2:172543902 DYNC1I2 -1.09 -18.22 -0.71 8.68e-52 Schizophrenia; CRC cis rs514406 0.668 rs520281 chr1:53365235 G/C cg25767906 chr1:53392781 SCP2 -0.49 -7.58 -0.39 3.53e-13 Monocyte count; CRC cis rs875971 0.862 rs4149461 chr7:65744732 T/C cg18252515 chr7:66147081 NA 0.39 5.72 0.3 2.45e-8 Aortic root size; CRC cis rs7552404 1.000 rs11161521 chr1:76216330 T/C cg22875332 chr1:76189707 ACADM 0.7 9.55 0.47 3.12e-19 Blood metabolite levels;Acylcarnitine levels; CRC trans rs6598955 0.671 rs12090258 chr1:26644698 C/T cg07461501 chr17:79650226 HGS;ARL16 -0.55 -6.45 -0.34 3.9e-10 Obesity-related traits; CRC cis rs4474465 0.850 rs4285892 chr11:78243134 C/A cg27205649 chr11:78285834 NARS2 0.49 6.27 0.33 1.11e-9 Alzheimer's disease (survival time); CRC cis rs8062405 0.755 rs4787455 chr16:28589455 G/A cg16576597 chr16:28551801 NUPR1 0.56 8.39 0.42 1.42e-15 Cognitive ability (multi-trait analysis);Cognitive ability; CRC cis rs6879260 1.000 rs729568 chr5:179732350 C/T cg23248424 chr5:179741104 GFPT2 0.62 9.36 0.46 1.3e-18 Height; CRC cis rs708547 0.874 rs1718869 chr4:57880232 A/C cg25525207 chr4:57843836 C4orf14;POLR2B -0.46 -5.7 -0.3 2.73e-8 Response to bleomycin (chromatid breaks); CRC cis rs765787 0.530 rs4775836 chr15:45537664 T/C cg24006582 chr15:45444508 DUOX1 -0.57 -8.63 -0.43 2.62e-16 Uric acid levels; CRC cis rs6502050 0.761 rs12150321 chr17:80061558 T/C cg02741985 chr17:80059408 CCDC57 -0.45 -7.25 -0.37 2.94e-12 Life satisfaction; CRC trans rs2727020 0.590 rs7949936 chr11:49378902 G/A cg15704280 chr7:45808275 SEPT13 -0.69 -8.52 -0.43 5.93e-16 Coronary artery disease; CRC cis rs7927592 0.956 rs7104877 chr11:68377602 G/T cg16797656 chr11:68205561 LRP5 -0.36 -5.88 -0.31 9.85e-9 Total body bone mineral density; CRC cis rs1448094 0.817 rs10863111 chr12:86330615 T/C cg00310523 chr12:86230176 RASSF9 0.43 7.26 0.37 2.88e-12 Major depressive disorder; CRC cis rs11212617 0.967 rs4753833 chr11:108057430 G/A cg01991180 chr11:108092276 ATM;NPAT 0.4 5.83 0.31 1.33e-8 Response to metformin in type 2 diabetes (glycemic); CRC cis rs9322193 0.923 rs9688452 chr6:149979900 G/A cg05861140 chr6:150128134 PCMT1 -0.38 -6.02 -0.32 4.6e-9 Lung cancer; CRC cis rs7937682 0.593 rs1944123 chr11:111356407 T/C cg09085632 chr11:111637200 PPP2R1B 0.41 5.71 0.3 2.52e-8 Primary sclerosing cholangitis; CRC cis rs3617 0.573 rs62253583 chr3:52928334 G/A cg18099408 chr3:52552593 STAB1 0.36 6.14 0.32 2.43e-9 Red blood cell count;Autism spectrum disorder or schizophrenia; CRC cis rs11696845 0.666 rs6103849 chr20:43365687 C/T cg25301532 chr20:43378953 KCNK15 -0.41 -6.94 -0.36 2.06e-11 Obesity-related traits; CRC cis rs2050392 0.829 rs306589 chr10:30723831 A/G cg18806716 chr10:30721971 MAP3K8 -0.49 -7.39 -0.38 1.2e-12 Inflammatory bowel disease; CRC cis rs1865760 1.000 rs9393675 chr6:25930116 G/A cg16482183 chr6:26056742 HIST1H1C 0.53 7.37 0.38 1.43e-12 Height; CRC cis rs281302 0.621 rs373553 chr15:47749001 G/C cg13159054 chr15:47721715 NA -0.43 -6.42 -0.33 4.65e-10 Educational attainment (years of education);Cognitive ability (multi-trait analysis); CRC cis rs11785693 0.862 rs6990234 chr8:4996812 A/G cg26367366 chr8:4980734 NA 0.81 9.75 0.47 6.71e-20 Neuroticism (multi-trait analysis);Neuroticism; CRC cis rs6951245 1.000 rs118059236 chr7:1073202 A/C cg04025307 chr7:1156635 C7orf50 0.63 6.63 0.34 1.41e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs7666738 0.830 rs7680909 chr4:98934604 A/G cg05340658 chr4:99064831 C4orf37 0.6 9.35 0.46 1.41e-18 Colonoscopy-negative controls vs population controls; CRC cis rs9911578 1.000 rs4793950 chr17:56593111 T/C cg12560992 chr17:57184187 TRIM37 -0.92 -17.23 -0.69 7.32e-48 Intelligence (multi-trait analysis); CRC cis rs1862618 0.573 rs832532 chr5:56221938 T/C cg24531977 chr5:56204891 C5orf35 -0.97 -14.02 -0.61 2.37e-35 Initial pursuit acceleration; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg14309743 chr22:50312258 ALG12;CRELD2 0.48 6.92 0.36 2.41e-11 Response to antipsychotic treatment; CRC cis rs9549367 0.789 rs12584813 chr13:113895443 C/G cg00898013 chr13:113819073 PROZ -0.43 -6.07 -0.32 3.59e-9 Platelet distribution width; CRC cis rs28386778 0.897 rs2859619 chr17:61917686 T/C cg06873352 chr17:61820015 STRADA 0.79 14.89 0.63 1.12e-38 Prudent dietary pattern; CRC cis rs8114671 0.562 rs6060064 chr20:33406339 C/G cg24642439 chr20:33292090 TP53INP2 -0.38 -6.1 -0.32 2.99e-9 Height; CRC cis rs4713118 0.824 rs9366702 chr6:27734470 T/C cg21204522 chr6:27730016 NA -0.42 -5.65 -0.3 3.43e-8 Parkinson's disease; CRC cis rs9398803 0.865 rs9398805 chr6:126726295 C/T cg19875578 chr6:126661172 C6orf173 0.42 5.89 0.31 9.49e-9 Male-pattern baldness; CRC cis rs1046896 0.553 rs3744160 chr17:80828303 G/A cg08200770 chr17:80723486 TBCD -0.48 -7.43 -0.38 9.65e-13 Glycated hemoglobin levels; CRC cis rs2033711 0.870 rs6510152 chr19:58953319 C/T cg13877915 chr19:58951672 ZNF132 0.48 7.65 0.39 2.26e-13 Uric acid clearance; CRC cis rs2046867 0.818 rs62249862 chr3:72867949 G/C cg25664220 chr3:72788482 NA -0.46 -6.65 -0.34 1.21e-10 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; CRC cis rs10193935 0.901 rs6544529 chr2:42510652 A/T cg27598129 chr2:42591480 NA -0.69 -7.91 -0.4 3.94e-14 Colonoscopy-negative controls vs population controls; CRC cis rs853679 0.517 rs4713145 chr6:28106827 T/C cg18032046 chr6:28092343 ZSCAN16 -0.52 -6.08 -0.32 3.3e-9 Depression; CRC cis rs2153535 0.547 rs9502720 chr6:8541362 C/A cg07606381 chr6:8435919 SLC35B3 0.68 11.23 0.53 5.44e-25 Motion sickness; CRC cis rs79387448 0.745 rs72993754 chr2:103151136 A/G cg09003973 chr2:102972529 NA 0.68 7.72 0.39 1.38e-13 Gut microbiota (bacterial taxa); CRC cis rs6921919 0.609 rs67211468 chr6:28391987 T/C cg21251018 chr6:28226885 NKAPL 0.4 6.08 0.32 3.25e-9 Autism spectrum disorder or schizophrenia; CRC cis rs57590327 0.555 rs2053805 chr3:81738414 T/C cg07356753 chr3:81810745 GBE1 -0.66 -8.82 -0.44 6.76e-17 Extraversion; CRC trans rs113835537 0.627 rs4630309 chr11:66333072 A/C cg02801645 chr22:24059735 LOC91316 0.56 6.02 0.31 4.59e-9 Airway imaging phenotypes; CRC cis rs9527 0.590 rs7920868 chr10:104795409 C/T cg04362960 chr10:104952993 NT5C2 0.59 8.36 0.42 1.81e-15 Arsenic metabolism; CRC trans rs1814175 0.791 rs9787917 chr11:49937281 C/T cg03929089 chr4:120376271 NA -0.98 -19.27 -0.73 6.62e-56 Height; CRC cis rs7607369 0.596 rs10165754 chr2:219287370 A/G cg02176678 chr2:219576539 TTLL4 -0.56 -8.18 -0.41 6.17e-15 Red blood cell count;Amyotrophic lateral sclerosis; CRC cis rs4660306 0.614 rs1765711 chr1:45936285 C/T cg03123370 chr1:45965343 CCDC163P;MMACHC 0.49 6.52 0.34 2.59e-10 Homocysteine levels; CRC cis rs34034915 1 rs34034915 chr6:27720703 T/TG cg02683197 chr6:28174875 NA 0.61 8.7 0.43 1.64e-16 Hepatitis A; CRC cis rs10540 0.915 rs12419209 chr11:494510 T/C cg08200582 chr11:442649 ANO9 -0.71 -7.42 -0.38 9.82e-13 Body mass index; CRC cis rs4862750 0.914 rs6837117 chr4:187872379 C/T cg03452623 chr4:187889614 NA -0.89 -19.74 -0.74 8.98e-58 Lobe attachment (rater-scored or self-reported); CRC cis rs748404 0.660 rs509306 chr15:43715171 A/G cg02155558 chr15:43621948 ADAL;LCMT2 0.53 7.88 0.4 4.67e-14 Lung cancer; CRC cis rs55702914 0.746 rs4850425 chr2:198152786 T/C cg20885578 chr2:198174922 NA -0.36 -6.27 -0.33 1.13e-9 Major depression and alcohol dependence; CRC cis rs9787249 0.957 rs10888958 chr1:40211737 T/C cg02773041 chr1:40204384 PPIE 0.64 9.58 0.47 2.45e-19 Blood protein levels; CRC cis rs1865760 0.613 rs9358894 chr6:25923315 C/T cg16482183 chr6:26056742 HIST1H1C 0.43 6.38 0.33 6.01e-10 Height; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg16870442 chr8:6264181 MCPH1 0.45 6.21 0.32 1.61e-9 Response to antipsychotic treatment; CRC cis rs12540874 0.794 rs1470750 chr7:50576648 C/G cg14593290 chr7:50529359 DDC -0.45 -6.15 -0.32 2.19e-9 Systemic sclerosis; CRC cis rs9914544 0.933 rs11871889 chr17:18771425 T/C cg26306683 chr17:18585705 ZNF286B 0.5 7.02 0.36 1.29e-11 Educational attainment (years of education); CRC cis rs7193541 0.564 rs4888274 chr16:74706298 A/T cg01733217 chr16:74700730 RFWD3 1.03 21.47 0.76 1.47e-64 Multiple myeloma; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg08020660 chr16:30076480 ALDOA 0.43 6.35 0.33 6.99e-10 Anxiety disorder; CRC cis rs1799949 0.965 rs4793230 chr17:41427403 A/C cg23758822 chr17:41437982 NA 0.93 18.6 0.72 2.71e-53 Menopause (age at onset); CRC cis rs73001065 0.591 rs57009615 chr19:19613622 A/G cg03709012 chr19:19516395 GATAD2A 0.89 8.11 0.41 1.03e-14 LDL cholesterol; CRC trans rs1493916 0.870 rs8083723 chr18:31384398 C/T cg27147174 chr7:100797783 AP1S1 -0.43 -7.16 -0.37 5.27e-12 Life satisfaction; CRC cis rs3087591 0.919 rs11080148 chr17:29609922 T/C cg24425628 chr17:29625626 OMG;NF1 -0.82 -14.37 -0.62 1.11e-36 Hip circumference; CRC trans rs1814175 0.645 rs7928714 chr11:49887622 G/A cg11707556 chr5:10655725 ANKRD33B -0.51 -9.67 -0.47 1.25e-19 Height; CRC cis rs10504229 1.000 rs57624567 chr8:58176995 T/C cg01721255 chr8:58191610 C8orf71 0.49 6.17 0.32 2e-9 Developmental language disorder (linguistic errors); CRC cis rs7301826 0.627 rs10773823 chr12:131294501 C/T cg11011512 chr12:131303247 STX2 0.37 5.62 0.3 4.1e-8 Plasma plasminogen activator levels; CRC cis rs9322193 0.923 rs4870267 chr6:149992708 C/G cg00933542 chr6:150070202 PCMT1 0.3 6.26 0.33 1.17e-9 Lung cancer; CRC cis rs9322193 0.962 rs9688809 chr6:150109056 C/T cg05861140 chr6:150128134 PCMT1 -0.43 -7.05 -0.36 1.03e-11 Lung cancer; CRC cis rs9925964 0.933 rs9939417 chr16:31053467 C/T cg02466173 chr16:30829666 NA 0.44 5.97 0.31 6.27e-9 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs9612 1.000 rs346527 chr19:44259361 A/G cg08581076 chr19:44259116 C19orf61 0.49 6.28 0.33 1.06e-9 Exhaled nitric oxide output; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg08546335 chr16:1877338 HAGH;FAHD1 0.44 6.02 0.31 4.75e-9 Anxiety disorder; CRC cis rs270601 0.633 rs733300 chr5:131572243 A/G cg27615366 chr5:131592974 PDLIM4 0.34 6.08 0.32 3.34e-9 Acylcarnitine levels; CRC cis rs9303401 0.659 rs35828828 chr17:56718205 C/T cg10487724 chr17:56770010 TEX14;RAD51C 0.79 9.71 0.47 9.1e-20 Cognitive test performance; CRC cis rs116095464 0.558 rs62344345 chr5:257420 C/T cg22857025 chr5:266934 NA -1.25 -16.68 -0.68 1.03e-45 Breast cancer; CRC cis rs7932354 0.655 rs6485690 chr11:46798631 A/G cg19486271 chr11:47235900 DDB2 -0.47 -7.66 -0.39 2.06e-13 Bone mineral density (hip);Bone mineral density; CRC cis rs433852 0.718 rs550455 chr19:49136515 A/G cg06677660 chr19:49140777 SEC1;DBP -0.45 -5.84 -0.31 1.26e-8 Elevated serum carcinoembryonic antigen levels;Posterior cortical atrophy and Alzheimer's disease; CRC trans rs2797160 1.000 rs1739367 chr6:126004720 G/T cg05039488 chr6:79577232 IRAK1BP1 -0.49 -7.32 -0.37 1.91e-12 Endometrial cancer; CRC cis rs6429082 0.608 rs903348 chr1:235571343 C/T cg26050004 chr1:235667680 B3GALNT2 -0.44 -5.76 -0.3 1.9e-8 Adiposity; CRC cis rs7659604 1.000 rs35901586 chr4:122664757 T/A cg19748678 chr4:122722346 EXOSC9 0.54 8.55 0.43 4.7e-16 Type 2 diabetes; CRC cis rs77633900 0.772 rs283802 chr15:76791270 C/T cg21673338 chr15:77095150 SCAPER -0.73 -6.66 -0.34 1.16e-10 Non-glioblastoma glioma;Glioma; CRC cis rs2354432 0.505 rs3737845 chr1:146724408 A/G cg25205988 chr1:146714368 CHD1L 1.15 9.46 0.46 6.23e-19 Mitochondrial DNA levels; CRC cis rs79387448 0.808 rs77518775 chr2:103237642 T/C cg21010569 chr2:103233596 NA 0.59 6.64 0.34 1.29e-10 Gut microbiota (bacterial taxa); CRC cis rs7481584 0.624 rs369461 chr11:3061992 A/G cg25174290 chr11:3078921 CARS -0.41 -5.76 -0.3 1.95e-8 Calcium levels; CRC cis rs972578 1.000 rs926351 chr22:43371176 T/C cg01576275 chr22:43409880 NA -0.45 -7.28 -0.37 2.47e-12 Mean platelet volume; CRC cis rs10504229 0.683 rs2291765 chr8:58142874 C/T cg02290350 chr8:58132656 NA -0.57 -8.44 -0.42 1.02e-15 Developmental language disorder (linguistic errors); CRC cis rs1059312 0.545 rs12303387 chr12:129276733 C/T cg21616243 chr12:129299702 MGC16384;SLC15A4 0.53 7.55 0.38 4.41e-13 Systemic lupus erythematosus; CRC cis rs4253772 0.513 rs12171124 chr22:46710693 A/C cg03482458 chr22:46692211 CN5H6.4;GTSE1 0.51 6.02 0.31 4.74e-9 LDL cholesterol;Cholesterol, total; CRC cis rs9393777 0.513 rs9368451 chr6:26654333 A/G cg12292205 chr6:26970375 C6orf41 -0.61 -6.99 -0.36 1.52e-11 Intelligence (multi-trait analysis); CRC cis rs1801251 0.685 rs1515961 chr2:233623763 C/A cg25237894 chr2:233734115 C2orf82 0.42 6.79 0.35 5.15e-11 Coronary artery disease; CRC cis rs477692 1.000 rs538969 chr10:131410608 C/T cg05714579 chr10:131428358 MGMT 0.53 7.76 0.39 1.09e-13 Response to temozolomide; CRC cis rs4423214 0.650 rs4245442 chr11:71220909 T/C cg05163923 chr11:71159392 DHCR7 0.56 7.08 0.36 8.76e-12 Vitamin D levels; CRC cis rs863345 0.625 rs6663286 chr1:158473725 C/A cg12129480 chr1:158549410 OR10X1 -0.3 -6.33 -0.33 7.99e-10 Pneumococcal bacteremia; CRC cis rs4665809 0.590 rs13387855 chr2:26420708 T/G cg26119090 chr2:26468346 HADHA;HADHB -1.05 -15.29 -0.64 3.04e-40 Gut microbiome composition (summer); CRC cis rs8180040 0.620 rs9875235 chr3:47083621 G/A cg27129171 chr3:47204927 SETD2 0.73 11.46 0.53 8.32e-26 Colorectal cancer; CRC cis rs769267 0.895 rs2916074 chr19:19530270 C/T cg01262667 chr19:19385393 TM6SF2 0.36 6.07 0.32 3.6e-9 Tonsillectomy; CRC cis rs597539 0.617 rs669659 chr11:68635623 G/C cg06028808 chr11:68637592 NA 0.41 6.73 0.35 7.71e-11 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs7811142 0.830 rs11765869 chr7:99964789 T/G cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.13 15.36 0.65 1.57e-40 Platelet count; CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg06622468 chr19:10491460 TYK2 0.41 6.5 0.34 2.99e-10 Obesity-related traits; CRC cis rs741668 0.894 rs2031633 chr13:46596140 C/T cg06018095 chr13:46550134 ZC3H13 0.43 5.92 0.31 7.95e-9 Cerebrospinal fluid clusterin levels; CRC trans rs7395662 1.000 rs7928083 chr11:48613148 C/G cg21153622 chr11:89784906 NA -0.48 -7.68 -0.39 1.78e-13 HDL cholesterol; CRC cis rs17270561 0.609 rs4712970 chr6:25770707 G/A cg16482183 chr6:26056742 HIST1H1C 0.7 8.69 0.43 1.78e-16 Iron status biomarkers; CRC cis rs10504229 0.679 rs17804870 chr8:58158071 A/G cg21724239 chr8:58056113 NA 0.78 9.06 0.45 1.22e-17 Developmental language disorder (linguistic errors); CRC cis rs13256369 1.000 rs12547721 chr8:8570671 C/T cg18904891 chr8:8559673 CLDN23 0.51 6.95 0.36 1.92e-11 Obesity-related traits; CRC cis rs1577917 0.958 rs34765423 chr6:86484448 C/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.63 -7.94 -0.4 3.16e-14 Response to antipsychotic treatment; CRC cis rs9291683 0.507 rs6845554 chr4:10013173 T/G cg11266682 chr4:10021025 SLC2A9 0.53 11.01 0.52 3.24e-24 Bone mineral density; CRC cis rs780096 0.506 rs2288155 chr2:27714526 T/C cg17158414 chr2:27665306 KRTCAP3 -0.29 -6.18 -0.32 1.9e-9 Total body bone mineral density; CRC cis rs2576037 0.583 rs641366 chr18:44430326 C/T cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.54 -8.38 -0.42 1.57e-15 Personality dimensions; CRC cis rs477895 0.713 rs12575642 chr11:63979643 G/T cg01518246 chr11:63870912 FLRT1;MACROD1 0.46 6.17 0.32 2.05e-9 Mean platelet volume; CRC cis rs9322193 0.607 rs6925151 chr6:150210723 C/T cg13206674 chr6:150067644 NUP43 0.44 5.94 0.31 7.21e-9 Lung cancer; CRC cis rs10504229 0.679 rs72649114 chr8:58037491 G/T cg02725872 chr8:58115012 NA -0.36 -6.17 -0.32 2.04e-9 Developmental language disorder (linguistic errors); CRC cis rs6088580 0.634 rs4911422 chr20:32999345 T/C cg24642439 chr20:33292090 TP53INP2 -0.37 -6.31 -0.33 8.76e-10 Glomerular filtration rate (creatinine); CRC cis rs7119 0.717 rs12910513 chr15:77817258 C/T cg10437265 chr15:77819839 NA 0.69 12.74 0.57 1.76e-30 Type 2 diabetes; CRC cis rs1881797 0.932 rs41305741 chr1:247689543 A/G cg11166453 chr1:247681781 NA 0.44 7.27 0.37 2.65e-12 Acute lymphoblastic leukemia (childhood); CRC cis rs56104184 0.830 rs17272645 chr19:49342366 C/G cg15549821 chr19:49342101 PLEKHA4 0.89 11.25 0.53 4.75e-25 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; CRC cis rs2735413 0.918 rs7190752 chr16:78077430 T/C cg04733911 chr16:78082701 NA -0.45 -7.5 -0.38 6.09e-13 Systolic blood pressure (alcohol consumption interaction); CRC cis rs9916302 0.904 rs8068427 chr17:37511517 G/A cg00129232 chr17:37814104 STARD3 0.54 7.85 0.4 5.97e-14 Glomerular filtration rate (creatinine); CRC cis rs6665290 0.669 rs3738725 chr1:227174210 T/C cg10327440 chr1:227177885 CDC42BPA -0.97 -20.15 -0.74 2.29e-59 Myeloid white cell count; CRC cis rs270601 0.633 rs733300 chr5:131572243 A/G cg04518342 chr5:131593106 PDLIM4 0.56 9.72 0.47 8.62e-20 Acylcarnitine levels; CRC cis rs853679 0.517 rs11552219 chr6:28126834 C/T cg15786705 chr6:28176104 NA 0.78 9.83 0.48 3.57e-20 Depression; CRC cis rs4700695 0.841 rs251294 chr5:65261848 A/G cg21114390 chr5:65439923 SFRS12 0.57 6.88 0.35 3.05e-11 Facial morphology (factor 19); CRC cis rs3096299 0.685 rs3803681 chr16:89544756 C/T cg01788221 chr16:89496183 ANKRD11 -0.4 -6.02 -0.31 4.66e-9 Multiple myeloma (IgH translocation); CRC cis rs597539 0.652 rs673821 chr11:68678718 G/T cg21963583 chr11:68658836 MRPL21 0.63 11.58 0.54 3.06e-26 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs3026445 0.832 rs7975364 chr12:110602275 A/T cg12870014 chr12:110450643 ANKRD13A 0.42 6.62 0.34 1.49e-10 QT interval; CRC cis rs6456156 0.792 rs10946213 chr6:167516095 A/G cg07513332 chr6:167530253 CCR6 -0.37 -6.32 -0.33 8.66e-10 Primary biliary cholangitis; CRC trans rs7615952 0.605 rs11708269 chr3:125332150 C/T cg02007433 chr3:129722099 NA -0.62 -6.07 -0.32 3.47e-9 Blood pressure (smoking interaction); CRC cis rs7914558 1.000 rs4917994 chr10:104811699 C/T cg15744005 chr10:104629667 AS3MT -0.33 -7.06 -0.36 9.89e-12 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs7659604 0.676 rs6855269 chr4:122697418 T/G cg20573242 chr4:122745356 CCNA2 0.52 7.61 0.39 2.91e-13 Type 2 diabetes; CRC cis rs798554 0.757 rs1182172 chr7:2878103 G/A cg14895029 chr7:2775587 GNA12 -0.4 -5.63 -0.3 3.9e-8 Height; CRC cis rs6502050 0.835 rs62078306 chr17:80085341 A/G cg13198984 chr17:80129470 CCDC57 -0.48 -8.56 -0.43 4.49e-16 Life satisfaction; CRC cis rs6952808 0.689 rs1107591 chr7:2041638 G/A cg22963979 chr7:1858916 MAD1L1 -0.52 -7.68 -0.39 1.78e-13 Bipolar disorder and schizophrenia; CRC cis rs6502050 0.777 rs11077969 chr17:80085633 A/G cg09264619 chr17:80180166 NA 0.36 6.08 0.32 3.4e-9 Life satisfaction; CRC cis rs4780401 0.642 rs7194145 chr16:11764615 T/G cg01061890 chr16:11836724 TXNDC11 -0.41 -5.61 -0.3 4.35e-8 Rheumatoid arthritis; CRC trans rs9858542 0.953 rs6446272 chr3:49463287 G/A cg21659725 chr3:3221576 CRBN -0.66 -9.16 -0.45 5.87e-18 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs7772486 0.688 rs1884364 chr6:146337817 C/G cg05347473 chr6:146136440 FBXO30 0.46 6.71 0.35 8.32e-11 Lobe attachment (rater-scored or self-reported); CRC cis rs7119 0.717 rs12916822 chr15:77818548 G/T cg27398640 chr15:77910606 LINGO1 -0.43 -7.47 -0.38 7.13e-13 Type 2 diabetes; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg23597375 chr22:42084934 NHP2L1 0.46 6.36 0.33 6.87e-10 Anxiety disorder; CRC cis rs34172651 0.917 rs11642302 chr16:24770856 G/A cg00339695 chr16:24857497 SLC5A11 0.28 6.55 0.34 2.16e-10 Intelligence (multi-trait analysis); CRC cis rs6662572 0.737 rs6680647 chr1:46345478 C/T cg03123370 chr1:45965343 CCDC163P;MMACHC 0.45 5.73 0.3 2.26e-8 Blood protein levels; CRC cis rs1577917 1.000 rs1337844 chr6:86677273 T/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.5 -6.66 -0.34 1.17e-10 Response to antipsychotic treatment; CRC trans rs875971 0.660 rs2191268 chr7:66110224 C/T ch.1.3875151R chr1:200949712 KIF21B -0.39 -6.24 -0.33 1.38e-9 Aortic root size; CRC trans rs11581859 0.950 rs6577238 chr1:99393710 T/C cg12183875 chr3:169587454 LRRC31 0.28 6.3 0.33 9.59e-10 Response to cognitive-behavioural therapy in anxiety disorder; CRC cis rs66887589 0.777 rs10015883 chr4:120268146 A/G cg09307838 chr4:120376055 NA 0.56 8.8 0.44 7.86e-17 Diastolic blood pressure; CRC cis rs9311676 0.656 rs11130635 chr3:58379143 A/G cg06643156 chr3:58380774 PXK 0.41 6.33 0.33 7.82e-10 Systemic lupus erythematosus; CRC cis rs6502050 0.835 rs28640920 chr17:80105151 A/T cg02741985 chr17:80059408 CCDC57 0.43 7.15 0.37 5.66e-12 Life satisfaction; CRC cis rs8010715 0.816 rs762093 chr14:24591918 G/C cg23112188 chr14:24563095 PCK2 -0.35 -7.02 -0.36 1.25e-11 IgG glycosylation; CRC cis rs2795502 0.630 rs1271547 chr10:43507665 C/T cg08461752 chr10:43522343 NA -0.82 -7.64 -0.39 2.45e-13 Blood protein levels; CRC cis rs1448094 0.512 rs11117057 chr12:86248546 C/T cg19622623 chr12:86230825 RASSF9 -0.41 -6.76 -0.35 6.45e-11 Major depressive disorder; CRC cis rs4665809 0.680 rs3955310 chr2:26290828 T/G cg04944784 chr2:26401820 FAM59B -0.59 -7.58 -0.39 3.46e-13 Gut microbiome composition (summer); CRC cis rs919433 0.680 rs6434934 chr2:198437386 C/G cg10820045 chr2:198174542 NA 0.39 6.71 0.35 8.4e-11 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC cis rs3858526 0.959 rs11039540 chr11:5928334 C/T cg13902645 chr11:5959945 NA -0.62 -8.67 -0.43 1.94e-16 DNA methylation (variation); CRC trans rs6066835 1.000 rs73136396 chr20:47337174 T/A cg21109867 chr19:55897418 RPL28 -0.76 -6.21 -0.32 1.59e-9 Multiple myeloma; CRC cis rs875971 0.545 rs316328 chr7:65608838 A/G cg02869306 chr7:64672164 INTS4L1 0.4 6.12 0.32 2.73e-9 Aortic root size; CRC cis rs514406 0.679 rs11585495 chr1:53244331 T/C cg08859206 chr1:53392774 SCP2 0.63 10.08 0.49 5.32e-21 Monocyte count; CRC cis rs780096 0.546 rs2293571 chr2:27729480 C/T cg12000995 chr2:27665139 KRTCAP3 -0.28 -5.79 -0.3 1.64e-8 Total body bone mineral density; CRC cis rs9487051 0.676 rs7773775 chr6:109600339 T/C cg21918786 chr6:109611834 NA -0.4 -7.13 -0.37 6.28e-12 Reticulocyte fraction of red cells; CRC trans rs7267979 1.000 rs6115140 chr20:25285507 C/A cg17903999 chr18:56338584 MALT1 -0.44 -7.23 -0.37 3.5e-12 Liver enzyme levels (alkaline phosphatase); CRC cis rs4680 1.000 rs4680 chr22:19951271 C/T cg22546130 chr22:19950026 COMT 0.27 7.24 0.37 3.17e-12 Blood metabolite levels; CRC cis rs7412746 0.658 rs2230061 chr1:150727539 G/A cg10589385 chr1:150898437 SETDB1 0.32 6.49 0.34 3.12e-10 Melanoma; CRC cis rs35110281 0.782 rs7282933 chr21:45046988 A/G cg04455712 chr21:45112962 RRP1B 0.41 7.98 0.4 2.47e-14 Mean corpuscular volume; CRC cis rs3540 0.513 rs2589974 chr15:90891566 C/T cg22089800 chr15:90895588 ZNF774 -0.61 -10.48 -0.5 2.22e-22 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; CRC cis rs7617480 0.616 rs7429596 chr3:48808531 T/C cg07636037 chr3:49044803 WDR6 0.87 10.29 0.49 1.01e-21 Subjective well-being (multi-trait analysis);Menarche (age at onset); CRC cis rs12580194 0.756 rs2169856 chr12:55572652 C/G cg19537932 chr12:55886519 OR6C68 0.52 5.92 0.31 8.06e-9 Cancer; CRC cis rs9322193 0.962 rs6903998 chr6:150152493 T/C cg13206674 chr6:150067644 NUP43 0.53 7.5 0.38 6.09e-13 Lung cancer; CRC cis rs4665809 1.000 rs7573118 chr2:26308086 A/G cg27170947 chr2:26402098 FAM59B -0.45 -6.06 -0.32 3.68e-9 Gut microbiome composition (summer); CRC cis rs10503871 0.905 rs6993734 chr8:30477733 T/C cg26383811 chr8:30366931 RBPMS 0.45 7.29 0.37 2.36e-12 Metabolite levels (X-11787); CRC cis rs10256972 0.552 rs2960830 chr7:1200641 T/C cg07308232 chr7:1071921 C7orf50 -0.42 -5.72 -0.3 2.36e-8 Longevity;Endometriosis; CRC cis rs9612 0.950 rs60649310 chr19:44269241 A/G cg08581076 chr19:44259116 C19orf61 0.46 5.7 0.3 2.66e-8 Exhaled nitric oxide output; CRC cis rs9322193 0.884 rs11155679 chr6:150080017 T/C cg13206674 chr6:150067644 NUP43 0.66 9.38 0.46 1.12e-18 Lung cancer; CRC cis rs8060686 0.920 rs16942887 chr16:67928042 G/A cg08314208 chr16:67682810 RLTPR -0.63 -7.22 -0.37 3.59e-12 HDL cholesterol;Metabolic syndrome; CRC cis rs11719291 0.651 rs1134043 chr3:49200137 G/T cg03060546 chr3:49711283 APEH -0.48 -5.76 -0.3 1.9e-8 Cognitive function; CRC cis rs17095355 1.000 rs7080576 chr10:111710817 C/T cg00817464 chr10:111662876 XPNPEP1 0.6 8.16 0.41 7.33e-15 Biliary atresia; CRC cis rs12760731 0.720 rs10913553 chr1:178423062 G/C cg00404053 chr1:178313656 RASAL2 0.97 10.21 0.49 1.85e-21 Obesity-related traits; CRC cis rs427943 0.778 rs13047803 chr21:46622369 T/C cg19498844 chr21:46707878 POFUT2;LOC642852 0.45 6.08 0.32 3.3e-9 Body mass index; CRC cis rs2354432 0.505 rs4424556 chr1:146863973 G/C cg25205988 chr1:146714368 CHD1L 1.15 10.02 0.48 8.48e-21 Mitochondrial DNA levels; CRC cis rs4757319 0.515 rs7934026 chr11:15339942 A/G cg03245590 chr11:15329459 NA 0.53 9.34 0.46 1.51e-18 Breast cancer; CRC cis rs9649213 0.593 rs13246942 chr7:97915021 C/T cg00277769 chr7:97922759 BAIAP2L1 -0.61 -10.81 -0.51 1.7e-23 Prostate cancer (SNP x SNP interaction); CRC cis rs2976388 0.609 rs2257796 chr8:143808667 T/C cg15511327 chr8:143859410 LYNX1 0.41 7.09 0.36 8.25e-12 Urinary tract infection frequency; CRC trans rs7267979 0.934 rs2257464 chr20:25265872 C/T cg17903999 chr18:56338584 MALT1 -0.41 -6.88 -0.35 3.08e-11 Liver enzyme levels (alkaline phosphatase); CRC cis rs12476592 0.571 rs6546005 chr2:63672071 G/A cg10828910 chr2:63850056 LOC388955 0.49 5.93 0.31 7.47e-9 Childhood ear infection; CRC cis rs9467711 0.538 rs35934643 chr6:26355094 G/A cg16898833 chr6:26189333 HIST1H4D 0.75 6.55 0.34 2.26e-10 Autism spectrum disorder or schizophrenia; CRC cis rs881375 0.935 rs7034390 chr9:123646488 A/T cg00246817 chr9:123691163 NA -0.45 -5.84 -0.31 1.22e-8 Rheumatoid arthritis; CRC cis rs4285028 0.948 rs71329247 chr3:121681523 C/T cg20356878 chr3:121714668 ILDR1 -0.48 -6.71 -0.35 8.68e-11 Multiple sclerosis; CRC cis rs1881797 1.000 rs1881794 chr1:247682920 G/C cg18198730 chr1:247681584 NA -0.59 -10.37 -0.5 5.7e-22 Acute lymphoblastic leukemia (childhood); CRC cis rs62064224 0.554 rs9889352 chr17:30775761 T/C cg25809561 chr17:30822961 MYO1D 0.58 10.56 0.5 1.24e-22 Schizophrenia; CRC cis rs4731207 0.724 rs57458159 chr7:124500810 C/T cg23710748 chr7:124431027 NA -0.38 -6.08 -0.32 3.42e-9 Cutaneous malignant melanoma; CRC cis rs6598955 0.724 rs12732295 chr1:26602251 C/T cg00852783 chr1:26633632 UBXN11 0.42 6.82 0.35 4.27e-11 Obesity-related traits; CRC cis rs67478160 0.619 rs12897150 chr14:104319530 A/T cg08213375 chr14:104286397 PPP1R13B 0.63 12.76 0.58 1.39e-30 Schizophrenia; CRC cis rs919433 0.926 rs12618567 chr2:198148191 A/T cg03934865 chr2:198174659 NA -0.45 -7.26 -0.37 2.83e-12 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC cis rs1448094 0.511 rs61930585 chr12:86158461 C/A cg02569458 chr12:86230093 RASSF9 0.51 8.43 0.42 1.07e-15 Major depressive disorder; CRC trans rs629535 0.814 rs55873935 chr8:70081646 G/A cg21567404 chr3:27674614 NA -0.93 -14.86 -0.63 1.48e-38 Dupuytren's disease; CRC cis rs10905065 0.965 rs2244755 chr10:5754611 G/A cg11519256 chr10:5708881 ASB13 0.43 6.14 0.32 2.31e-9 Menopause (age at onset); CRC cis rs6724607 1.000 rs4321393 chr2:191452899 G/T cg21644426 chr2:191273491 MFSD6 0.48 6.44 0.33 4.26e-10 Pulse pressure; CRC cis rs6502050 0.765 rs6502075 chr17:80121813 G/A cg22110888 chr17:80059540 CCDC57 0.4 6.38 0.33 5.96e-10 Life satisfaction; CRC cis rs7772486 0.754 rs697054 chr6:146003770 C/T cg23711669 chr6:146136114 FBXO30 0.76 13.09 0.59 8.18e-32 Lobe attachment (rater-scored or self-reported); CRC cis rs294883 0.739 rs4709291 chr6:159730267 T/C cg14500486 chr6:159655392 FNDC1 -0.36 -6.19 -0.32 1.81e-9 Coronary artery disease; CRC cis rs889312 0.500 rs185219 chr5:56136492 A/G cg24531977 chr5:56204891 C5orf35 -0.45 -6.76 -0.35 6.34e-11 Breast cancer;Breast cancer (early onset); CRC cis rs561341 0.825 rs2008368 chr17:30347397 T/C cg23018236 chr17:30244563 NA -0.69 -8.35 -0.42 1.89e-15 Hip circumference adjusted for BMI; CRC cis rs875971 0.545 rs6460281 chr7:65681115 A/C cg03233332 chr7:66118400 NA -0.45 -6.26 -0.33 1.22e-9 Aortic root size; CRC trans rs7267979 0.932 rs424487 chr20:25468131 C/G cg17903999 chr18:56338584 MALT1 -0.39 -6.64 -0.34 1.3100000000000001e-10 Liver enzyme levels (alkaline phosphatase); CRC cis rs73200209 0.744 rs11614312 chr12:116694851 A/G cg01776926 chr12:116560359 MED13L 0.6 7.28 0.37 2.51e-12 Total body bone mineral density; CRC cis rs2153535 0.580 rs9406161 chr6:8466144 G/T cg21535247 chr6:8435926 SLC35B3 0.5 7.53 0.38 4.89e-13 Motion sickness; CRC cis rs3820068 0.705 rs4646031 chr1:15834648 A/G cg27534772 chr1:16042836 PLEKHM2 0.42 7.09 0.36 8.14e-12 Systolic blood pressure; CRC cis rs12681287 0.640 rs13267782 chr8:87481887 G/T cg27223183 chr8:87520930 FAM82B -0.53 -7.52 -0.38 5.31e-13 Caudate activity during reward; CRC cis rs3807375 1.000 rs3807375 chr7:150667210 C/T cg10636020 chr7:150656979 KCNH2 -0.31 -5.65 -0.3 3.48e-8 Electrocardiographic traits;QT interval; CRC cis rs11645898 0.748 rs3852785 chr16:72198642 G/A cg14768367 chr16:72042858 DHODH -0.6 -6.53 -0.34 2.56e-10 Blood protein levels; CRC cis rs13108904 0.901 rs12641735 chr4:1304434 G/C cg19318889 chr4:1322082 MAEA 0.43 6.45 0.33 4.08e-10 Obesity-related traits; CRC trans rs10506458 0.688 rs60936040 chr12:63416461 G/A cg22491629 chr6:157744540 C6orf35 -0.53 -6.75 -0.35 6.71e-11 Hemostatic factors and hematological phenotypes; CRC cis rs2576037 0.526 rs4258717 chr18:44456954 T/C cg23996704 chr18:44553084 KATNAL2 -0.36 -7.39 -0.38 1.2e-12 Personality dimensions; CRC cis rs4665809 0.590 rs4665321 chr2:26433801 A/C cg25036284 chr2:26402008 FAM59B -0.62 -7.83 -0.4 6.87e-14 Gut microbiome composition (summer); CRC cis rs12612619 0.591 rs12714092 chr2:27314882 G/A cg00617064 chr2:27272375 NA 0.4 6.23 0.32 1.44e-9 Venous thromboembolism adjusted for sickle cell variant rs77121243-T; CRC cis rs995000 0.931 rs1748195 chr1:63049593 C/G cg19896129 chr1:63156450 NA -0.38 -5.96 -0.31 6.66e-9 Triglyceride levels; CRC cis rs6570726 0.791 rs6570693 chr6:145910841 C/T cg05347473 chr6:146136440 FBXO30 0.38 5.71 0.3 2.52e-8 Lobe attachment (rater-scored or self-reported); CRC cis rs2786111 0.965 rs1415214 chr1:197283185 C/T cg13682187 chr1:196946512 CFHR5 0.29 5.71 0.3 2.47e-8 Lupus nephritis in systemic lupus erythematosus; CRC cis rs6502050 0.799 rs34795957 chr17:80118013 G/A cg09264619 chr17:80180166 NA -0.35 -5.93 -0.31 7.76e-9 Life satisfaction; CRC trans rs1973993 0.967 rs1555543 chr1:96944797 A/C cg10631902 chr5:14652156 NA 0.51 9.12 0.45 7.65e-18 Weight; CRC cis rs7618915 0.547 rs34537256 chr3:52657472 A/G cg10802521 chr3:52805072 NEK4 -0.58 -8.83 -0.44 6.26e-17 Bipolar disorder; CRC cis rs12519773 0.576 rs55971857 chr5:92441594 A/C cg18783429 chr5:92414398 NA 0.33 6.9 0.36 2.61e-11 Migraine; CRC cis rs2455601 0.608 rs11042104 chr11:8890924 C/G cg21881798 chr11:8931708 C11orf17;ST5 0.52 6.91 0.36 2.49e-11 Schizophrenia; CRC cis rs4237845 0.773 rs6650217 chr12:58289072 T/G cg00677455 chr12:58241039 CTDSP2 0.52 7.47 0.38 7.08e-13 Intelligence (multi-trait analysis); CRC cis rs2290405 0.593 rs12499663 chr4:888170 G/A cg08222618 chr4:941054 TMEM175 0.36 6.07 0.32 3.45e-9 Systemic sclerosis; CRC cis rs57221529 0.709 rs72706612 chr5:561198 C/T cg14541582 chr5:601475 NA -0.33 -6.42 -0.33 4.64e-10 Lung disease severity in cystic fibrosis; CRC cis rs12926788 0.546 rs200531 chr16:24756172 G/A cg02428538 chr16:24856791 SLC5A11 0.56 6.71 0.35 8.45e-11 Ejection fraction in Tripanosoma cruzi seropositivity; CRC cis rs12220238 1.000 rs2279648 chr10:75867193 G/T cg19889307 chr10:75911429 ADK;AP3M1 0.6 5.61 0.3 4.22e-8 Soluble interleukin-2 receptor subunit alpha; CRC cis rs601339 1.000 rs1798219 chr12:123180061 A/C cg25190513 chr12:123201362 GPR109B -0.49 -6.27 -0.33 1.11e-9 Adiponectin levels; CRC cis rs12983728 0.831 rs35081008 chr19:58662235 C/T cg24884572 chr19:58661833 ZNF329 0.79 8.67 0.43 1.97e-16 Cholesterol, total; CRC cis rs6879260 1.000 rs7730585 chr5:179733440 T/C cg23221052 chr5:179740743 GFPT2 -0.61 -9.36 -0.46 1.25e-18 Height; CRC cis rs6540556 0.768 rs6692012 chr1:209935490 A/G cg23920097 chr1:209922102 NA -0.51 -6.34 -0.33 7.36e-10 Red blood cell count; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg05672380 chr19:36505394 ALKBH6 0.54 7.75 0.39 1.13e-13 Response to antipsychotic treatment; CRC cis rs9549260 0.709 rs9549247 chr13:41220777 G/C cg21288729 chr13:41239152 FOXO1 0.49 7.69 0.39 1.67e-13 Red blood cell count; CRC cis rs4700695 0.668 rs153393 chr5:65428707 A/G cg21114390 chr5:65439923 SFRS12 -0.6 -8.21 -0.41 5.04e-15 Facial morphology (factor 19); CRC cis rs5758511 0.680 rs5758692 chr22:42669029 T/A cg00645731 chr22:42541494 CYP2D7P1 0.63 9.55 0.47 3.13e-19 Birth weight; CRC cis rs12325245 0.536 rs35832551 chr16:58591444 G/T cg19824325 chr16:58548873 SETD6 0.9 6.09 0.32 3.09e-9 Schizophrenia; CRC cis rs250677 0.687 rs250666 chr5:148454622 A/G cg23229984 chr5:148520753 ABLIM3 0.5 6.93 0.36 2.16e-11 Breast cancer; CRC cis rs2077654 0.822 rs1805036 chr11:17434284 G/A cg25308976 chr11:17434268 ABCC8 0.79 8.27 0.41 3.45e-15 Gout; CRC trans rs9929218 1.000 rs8044058 chr16:68807088 G/A cg04657470 chr2:198365150 HSPE1;HSPD1 -0.83 -11.85 -0.55 3.21e-27 Colorectal cancer; CRC cis rs72781680 0.716 rs6731314 chr2:24048338 C/T cg08917208 chr2:24149416 ATAD2B -0.54 -6.42 -0.33 4.65e-10 Lymphocyte counts; CRC cis rs2239547 0.563 rs6445547 chr3:52908577 T/C cg11645453 chr3:52864694 ITIH4 0.53 9.19 0.45 4.7e-18 Schizophrenia; CRC trans rs2797160 1.000 rs1739376 chr6:126012084 C/G cg05039488 chr6:79577232 IRAK1BP1 0.5 7.55 0.38 4.44e-13 Endometrial cancer; CRC cis rs175714 0.845 rs175702 chr14:75971133 G/T cg01624173 chr14:75981868 NA -0.51 -8.39 -0.42 1.45e-15 Lymphocyte counts; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg16492226 chr5:83014308 HAPLN1 0.43 6.2 0.32 1.74e-9 Response to antipsychotic treatment; CRC cis rs2425143 1.000 rs11907811 chr20:34428078 A/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.49 -5.95 -0.31 7.05e-9 Blood protein levels; CRC cis rs6479527 0.875 rs10821285 chr9:96791789 C/T cg14459158 chr9:96720562 NA 0.39 6.95 0.36 1.96e-11 Esophageal adenocarcinoma; CRC cis rs3617 0.573 rs9850563 chr3:52912214 G/A cg07507251 chr3:52567010 NT5DC2 -0.39 -6.02 -0.32 4.53e-9 Red blood cell count;Autism spectrum disorder or schizophrenia; CRC cis rs77861329 1.000 rs352153 chr3:52211184 A/T cg08692210 chr3:52188851 WDR51A 0.78 7.39 0.38 1.2e-12 Macrophage inflammatory protein 1b levels; CRC cis rs8180040 0.902 rs73081205 chr3:47517670 A/C cg02527881 chr3:46936655 PTH1R 0.39 7.19 0.37 4.31e-12 Colorectal cancer; CRC cis rs644799 1.000 rs518919 chr11:95623313 G/C cg25622487 chr11:95524042 FAM76B;CEP57 0.74 11.28 0.53 3.49e-25 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs4713118 0.868 rs760587 chr6:27740300 C/A cg03623178 chr6:28175578 NA 0.75 8.36 0.42 1.77e-15 Parkinson's disease; CRC cis rs7119 0.717 rs11629835 chr15:77787469 G/T cg17802220 chr15:77601643 NA -0.47 -6.93 -0.36 2.28e-11 Type 2 diabetes; CRC cis rs7208859 0.673 rs9899525 chr17:29120296 T/A cg13385521 chr17:29058706 SUZ12P 0.74 8.44 0.42 9.97e-16 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg24098762 chr5:137667672 CDC25C 0.47 7.01 0.36 1.32e-11 Intelligence (multi-trait analysis); CRC cis rs1448094 0.511 rs10779207 chr12:86152913 A/G cg19622623 chr12:86230825 RASSF9 0.38 5.81 0.31 1.46e-8 Major depressive disorder; CRC cis rs669446 0.562 rs10890275 chr1:44194216 T/G cg12908607 chr1:44402522 ARTN -0.34 -5.79 -0.3 1.62e-8 Amyotrophic lateral sclerosis (age of onset); CRC cis rs936229 0.705 rs936227 chr15:75131959 A/G cg17294928 chr15:75287854 SCAMP5 0.38 5.76 0.3 1.93e-8 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); CRC cis rs9611565 0.659 rs12483998 chr22:41935362 A/G cg06634786 chr22:41940651 POLR3H -0.73 -8.41 -0.42 1.24e-15 Vitiligo; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg24479509 chr21:45209770 RRP1 0.45 6.02 0.31 4.56e-9 Anxiety disorder; CRC cis rs9303401 0.703 rs8077052 chr17:57208921 T/G cg02118635 chr17:56770003 RAD51C;TEX14 0.49 7.13 0.37 6.33e-12 Cognitive test performance; CRC cis rs4481887 0.927 rs4292985 chr1:248473692 T/A cg00666640 chr1:248458726 OR2T12 0.45 7.8 0.4 8.31e-14 Common traits (Other); CRC cis rs12900413 0.523 rs11636525 chr15:90300478 A/G cg24249390 chr15:90295951 MESP1 -0.58 -8.91 -0.44 3.45e-17 Coronary artery aneurysm in Kawasaki disease; CRC cis rs600806 0.888 rs10858084 chr1:109882250 T/A cg23032129 chr1:109941072 SORT1 -0.28 -6.03 -0.32 4.28e-9 Intelligence (multi-trait analysis); CRC cis rs6964587 1.000 rs11982213 chr7:91722966 A/G cg17063962 chr7:91808500 NA 0.78 13.78 0.6 2.1e-34 Breast cancer; CRC cis rs9486719 0.857 rs11759769 chr6:97065212 G/A cg18709589 chr6:96969512 KIAA0776 -0.5 -6.15 -0.32 2.28e-9 Migraine;Coronary artery disease; CRC cis rs8177253 0.763 rs6797713 chr3:133474832 T/C cg01448562 chr3:133502909 NA -0.47 -7.53 -0.38 5.08e-13 Iron status biomarkers; CRC cis rs12936587 0.748 rs12939297 chr17:17524247 G/A cg24612305 chr17:17875800 TOM1L2;LRRC48 -0.43 -5.79 -0.3 1.68e-8 Hip circumference;Coronary artery disease or large artery stroke;Coronary heart disease;Coronary artery disease; CRC cis rs2932538 0.922 rs12750023 chr1:113118329 G/A cg22162597 chr1:113214053 CAPZA1 0.71 10.31 0.49 8.69e-22 Systolic blood pressure;Diastolic blood pressure;Hypertension;Blood pressure; CRC cis rs7552404 1.000 rs12126607 chr1:76217097 G/A cg22875332 chr1:76189707 ACADM 0.7 9.43 0.46 7.56e-19 Blood metabolite levels;Acylcarnitine levels; CRC cis rs9660180 0.839 rs12040826 chr1:1705287 A/C cg17747265 chr1:1875780 NA -0.74 -12.65 -0.57 3.75e-30 Body mass index; CRC cis rs9443645 0.869 rs6913028 chr6:79513590 C/T cg11833968 chr6:79620685 NA -0.35 -6.17 -0.32 1.96e-9 Intelligence (multi-trait analysis); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg22240667 chr16:14396276 NA 0.43 6.28 0.33 1.08e-9 Intelligence (multi-trait analysis); CRC cis rs11123610 0.520 rs66557864 chr2:3720812 C/A cg19052272 chr2:3704530 ALLC -0.62 -7.6 -0.39 3.05e-13 Response to inhaled corticosteroid treatment in asthma (change in FEV1); CRC trans rs1814175 0.817 rs7927373 chr11:49957640 A/C cg03929089 chr4:120376271 NA -0.94 -17.92 -0.7 1.32e-50 Height; CRC cis rs653465 0.739 rs1357245 chr3:27186602 C/T cg02860705 chr3:27208620 NA -0.38 -5.99 -0.31 5.45e-9 Breast cancer (early onset); CRC cis rs9733 0.519 rs7521898 chr1:150707596 G/A cg15448220 chr1:150897856 SETDB1 0.48 6.83 0.35 4.16e-11 Tonsillectomy; CRC cis rs7762018 0.660 rs78181018 chr6:170096652 A/C cg19338460 chr6:170058176 WDR27 -1.24 -11.09 -0.52 1.67e-24 Thiazide-induced adverse metabolic effects in hypertensive patients; CRC cis rs1670533 1.000 rs62879260 chr4:1050850 T/C cg27284194 chr4:1044797 NA 0.51 6.23 0.33 1.39e-9 Recombination rate (females); CRC cis rs56114371 0.530 rs169262 chr6:27770890 C/T cg20933634 chr6:27740509 NA 0.61 7.8 0.4 8.12e-14 Breast cancer; CRC cis rs1347297 0.789 rs7589565 chr2:179282337 A/G cg03991736 chr2:179345203 MIR548N;PLEKHA3 -0.39 -5.64 -0.3 3.64e-8 Alzheimer disease and age of onset; CRC cis rs13118159 0.509 rs4974556 chr4:1358141 G/C cg02475777 chr4:1388615 CRIPAK 0.51 6.53 0.34 2.46e-10 Longevity; CRC cis rs7527798 0.592 rs12025522 chr1:207854355 A/C cg09232269 chr1:207846808 CR1L 0.46 7.5 0.38 6.09e-13 Erythrocyte sedimentation rate; CRC trans rs875971 0.660 rs2191268 chr7:66110224 C/T cg22717211 chr17:48944309 NA -0.4 -6.24 -0.33 1.37e-9 Aortic root size; CRC cis rs1448094 0.512 rs61930137 chr12:86242930 C/T cg02569458 chr12:86230093 RASSF9 0.42 7.24 0.37 3.17e-12 Major depressive disorder; CRC cis rs2108622 0.711 rs12609820 chr19:15978057 T/C cg13772218 chr19:15982569 NA 0.48 6.69 0.35 9.62e-11 Circulating phylloquinone levels;Vitamin E levels;Acenocoumarol maintenance dosage;Response to Vitamin E supplementation;Metabolite levels;Warfarin maintenance dose; CRC cis rs1619661 0.530 rs1627329 chr10:44691633 A/G cg09554077 chr10:44749378 NA 0.49 7.51 0.38 5.68e-13 QT interval (ambient particulate matter interaction); CRC cis rs4319547 0.956 rs10744275 chr12:123048618 A/G cg05707623 chr12:122985044 ZCCHC8 -0.8 -9.97 -0.48 1.25e-20 Body mass index; CRC cis rs644148 0.836 rs2686775 chr19:45000059 C/T cg15540054 chr19:45004280 ZNF180 -0.59 -8.28 -0.42 3.04e-15 Personality dimensions; CRC cis rs10267417 0.603 rs12333603 chr7:19907821 C/G cg07541023 chr7:19748670 TWISTNB -0.5 -5.8 -0.3 1.58e-8 Night sleep phenotypes; CRC cis rs9467711 0.606 rs34550936 chr6:26361985 A/G cg16898833 chr6:26189333 HIST1H4D 0.75 6.55 0.34 2.26e-10 Autism spectrum disorder or schizophrenia; CRC cis rs10504229 0.683 rs7822631 chr8:58130916 C/G cg04204079 chr8:58130323 NA -0.45 -5.78 -0.3 1.71e-8 Developmental language disorder (linguistic errors); CRC trans rs17607347 0.738 rs806733 chr16:72406328 T/C cg27230510 chr3:50404023 CACNA2D2 -0.54 -5.99 -0.31 5.53e-9 Intelligence (multi-trait analysis); CRC cis rs10256972 0.616 rs4998392 chr7:1113344 A/C cg16145915 chr7:1198662 ZFAND2A -0.31 -5.89 -0.31 9.47e-9 Longevity;Endometriosis; CRC trans rs2270927 1.000 rs4546360 chr5:75577563 T/C cg13563193 chr19:33072644 PDCD5 0.72 7.97 0.4 2.65e-14 Mean corpuscular volume; CRC cis rs2635047 0.600 rs2635056 chr18:44710568 G/A cg19077165 chr18:44547161 KATNAL2 -0.42 -6.62 -0.34 1.48e-10 Educational attainment; CRC cis rs11958404 0.932 rs72816563 chr5:157427447 C/T cg05962755 chr5:157440814 NA 0.88 11.49 0.53 6.67e-26 IgG glycosylation; CRC cis rs4332037 0.624 rs58169303 chr7:1883274 T/C cg25834613 chr7:1915315 MAD1L1 -0.4 -6.21 -0.32 1.62e-9 Bipolar disorder; CRC cis rs1552244 1.000 rs17032268 chr3:10067972 C/T cg08888203 chr3:10149979 C3orf24 0.69 9.69 0.47 1.04e-19 Alzheimer's disease; CRC cis rs34779708 0.931 rs35848945 chr10:35287561 G/T cg03585969 chr10:35415529 CREM 0.64 8.55 0.43 4.75e-16 Inflammatory bowel disease;Crohn's disease; CRC trans rs6860806 0.507 rs169256 chr5:131688533 A/G cg18525740 chr5:176449647 ZNF346 0.49 6.04 0.32 4.09e-9 Breast cancer; CRC cis rs12188164 0.965 rs56146525 chr5:442571 A/C cg16322479 chr5:444228 EXOC3;C5orf55 0.49 7.91 0.4 3.97e-14 Cystic fibrosis severity; CRC trans rs2243480 1.000 rs13310597 chr7:65598540 A/G cg10756647 chr7:56101905 PSPH 0.74 7.74 0.39 1.23e-13 Diabetic kidney disease; CRC cis rs9443645 0.901 rs9361466 chr6:79618352 T/C cg05283184 chr6:79620031 NA -0.57 -9.06 -0.45 1.18e-17 Intelligence (multi-trait analysis); CRC cis rs10046574 0.634 rs77474267 chr7:135098679 G/A cg27474649 chr7:135195673 CNOT4 0.69 5.71 0.3 2.58e-8 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs877282 0.891 rs12767043 chr10:797943 C/T cg17470449 chr10:769945 NA 0.67 8.93 0.44 3.07e-17 Uric acid levels; CRC cis rs1448094 0.967 rs7313443 chr12:86332940 G/A cg18827107 chr12:86230957 RASSF9 -0.37 -6.1 -0.32 2.98e-9 Major depressive disorder; CRC cis rs2749592 1.000 rs2749592 chr10:38258842 A/C cg00409905 chr10:38381863 ZNF37A -0.48 -6.76 -0.35 6.45e-11 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs9611565 0.608 rs202652 chr22:41838792 A/G cg06634786 chr22:41940651 POLR3H 0.55 6.71 0.35 8.44e-11 Vitiligo; CRC trans rs11039798 0.920 rs11040013 chr11:48782862 G/A cg03929089 chr4:120376271 NA 0.62 5.99 0.31 5.44e-9 Axial length; CRC cis rs2949837 0.581 rs2965068 chr7:45974375 T/C cg04796162 chr7:45961102 IGFBP3 0.38 6.73 0.35 7.47e-11 Sitting height ratio; CRC cis rs7113874 0.569 rs4418812 chr11:8612000 A/G cg02811074 chr11:8615871 STK33 0.35 6.0 0.31 5.19e-9 Body mass index in physically active individuals;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs9311474 0.607 rs28661185 chr3:52567188 G/T cg18099408 chr3:52552593 STAB1 -0.52 -9.11 -0.45 8.14e-18 Electroencephalogram traits; CRC cis rs9486719 1.000 rs11152969 chr6:96908712 A/C cg06623918 chr6:96969491 KIAA0776 -0.79 -9.2 -0.45 4.18e-18 Migraine;Coronary artery disease; CRC trans rs587242 1.000 rs662450 chr1:96891547 C/G cg10631902 chr5:14652156 NA 0.45 6.9 0.36 2.7e-11 Body mass index (joint analysis main effects and physical activity interaction);Body mass index in physically inactive individuals;Body mass index; CRC cis rs1153858 0.945 rs1974981 chr15:45729123 C/T cg21132104 chr15:45694354 SPATA5L1 -0.56 -8.09 -0.41 1.13e-14 Homoarginine levels; CRC cis rs9814567 0.964 rs3856729 chr3:134200925 A/G cg06541857 chr3:134203789 ANAPC13;CEP63 -0.4 -6.01 -0.31 4.84e-9 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs1552244 0.572 rs3894321 chr3:10168892 A/C cg13047869 chr3:10149882 C3orf24 0.54 6.67 0.35 1.09e-10 Alzheimer's disease; CRC cis rs2836974 1.000 rs2836974 chr21:40663181 A/G cg06238570 chr21:40685208 BRWD1 -0.79 -10.84 -0.51 1.25e-23 Cognitive function; CRC cis rs17767392 0.781 rs8008605 chr14:72045544 C/G cg13720639 chr14:72061746 SIPA1L1 0.52 5.94 0.31 7.38e-9 Mitral valve prolapse; CRC cis rs154659 1.000 rs154659 chr16:89667337 C/T cg01710450 chr16:89662404 CPNE7 0.42 5.83 0.31 1.34e-8 Tanning; CRC cis rs9457247 1.000 rs429083 chr6:167383972 T/C cg23791538 chr6:167370224 RNASET2 -0.38 -5.95 -0.31 6.86e-9 Crohn's disease; CRC cis rs10540 1.000 rs12786555 chr11:506229 C/T cg19913688 chr11:428466 ANO9 -0.7 -7.19 -0.37 4.26e-12 Body mass index; CRC cis rs951366 0.873 rs823118 chr1:205723572 C/T cg24503407 chr1:205819492 PM20D1 0.51 7.63 0.39 2.53e-13 Menarche (age at onset); CRC cis rs1506636 0.962 rs1472808 chr7:123354536 A/G cg03229431 chr7:123269106 ASB15 -0.74 -11.96 -0.55 1.28e-27 Plateletcrit;Platelet count; CRC cis rs6460942 0.591 rs75804221 chr7:12364319 C/T cg06484146 chr7:12443880 VWDE -0.6 -6.48 -0.34 3.38e-10 Coronary artery disease; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg07318372 chr1:240071102 CHRM3 -0.48 -7.24 -0.37 3.29e-12 Liver disease severity in Alagille syndrome; CRC cis rs6752107 1.000 rs2289472 chr2:234182240 C/T cg07618928 chr2:234183455 ATG16L1;SCARNA5 0.67 11.65 0.54 1.73e-26 Crohn's disease;Inflammatory bowel disease; CRC cis rs10256972 0.521 rs10280960 chr7:1103697 A/G cg03923535 chr7:1197113 ZFAND2A 0.52 7.68 0.39 1.84e-13 Longevity;Endometriosis; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg01196388 chr7:99063916 ATP5J2 0.45 6.19 0.32 1.83e-9 Response to antipsychotic treatment; CRC cis rs909674 0.524 rs5757670 chr22:39829736 G/A cg25956985 chr22:39795188 MAP3K7IP1 -0.44 -6.45 -0.34 4e-10 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; CRC cis rs9311474 0.659 rs7638808 chr3:52572056 C/T cg08222913 chr3:52553049 STAB1 0.37 7.19 0.37 4.38e-12 Electroencephalogram traits; CRC cis rs6502050 0.761 rs62078754 chr17:80058666 C/T cg13939156 chr17:80058883 NA 0.37 5.65 0.3 3.39e-8 Life satisfaction; CRC cis rs990171 1.000 rs10469840 chr2:103093243 T/C cg03938978 chr2:103052716 IL18RAP 0.45 5.71 0.3 2.5e-8 Lymphocyte counts; CRC cis rs12451471 0.500 rs8077056 chr17:78076006 C/T cg12100956 chr17:78086420 GAA -0.38 -6.05 -0.32 3.95e-9 Plateletcrit;Mean corpuscular hemoglobin concentration; CRC cis rs6860806 0.507 rs272891 chr5:131664394 G/T cg11843238 chr5:131593191 PDLIM4 0.43 7.27 0.37 2.6e-12 Breast cancer; CRC cis rs12291225 0.679 rs11605531 chr11:14291594 A/G cg19336497 chr11:14380999 RRAS2 -0.51 -8.53 -0.43 5.24e-16 Sense of smell; CRC cis rs67478160 0.643 rs876002 chr14:104239697 G/A cg01849466 chr14:104193079 ZFYVE21 -0.5 -9.0 -0.44 1.84e-17 Schizophrenia; CRC cis rs3768617 0.510 rs10752903 chr1:183100863 A/G ch.1.3577855R chr1:183094577 LAMC1 0.89 15.86 0.66 1.84e-42 Fuchs's corneal dystrophy; CRC cis rs9399135 0.967 rs4896125 chr6:135342569 C/T cg24558204 chr6:135376177 HBS1L 0.52 8.23 0.41 4.52e-15 Red blood cell count; CRC cis rs17376456 0.877 rs10072592 chr5:93405989 C/G cg09848695 chr5:92956644 FAM172A;MIR2277 0.64 5.88 0.31 1.03e-8 Diabetic retinopathy; CRC cis rs904251 0.965 rs1317563 chr6:37451854 G/T cg25019722 chr6:37503610 NA -0.33 -5.74 -0.3 2.18e-8 Cognitive performance; CRC cis rs6938 0.618 rs1133323 chr15:75212225 C/T cg17294928 chr15:75287854 SCAMP5 0.54 8.0 0.4 2.09e-14 Breast cancer; CRC cis rs274567 0.501 rs2631368 chr5:131705297 T/G cg22638593 chr5:131593259 PDLIM4 -0.41 -6.92 -0.36 2.44e-11 Blood metabolite levels; CRC cis rs6696846 0.715 rs61822659 chr1:205142847 G/A cg03948781 chr1:205179583 DSTYK 0.43 5.97 0.31 6.18e-9 Red blood cell count; CRC cis rs13253111 0.624 rs7832318 chr8:28110414 A/G cg26534493 chr8:28060551 NA 0.43 7.61 0.39 2.95e-13 Childhood body mass index; CRC trans rs1005277 0.579 rs9418322 chr10:38377296 G/T cg27523141 chr10:43048294 ZNF37B 0.5 7.35 0.38 1.55e-12 Extrinsic epigenetic age acceleration; CRC cis rs11958404 0.932 rs72816566 chr5:157427613 G/A cg05962755 chr5:157440814 NA 0.83 11.03 0.52 2.88e-24 IgG glycosylation; CRC cis rs9427116 1.000 rs9330261 chr1:154634998 T/A cg24304309 chr1:154577895 ADAR 0.37 6.03 0.32 4.51e-9 Blood protein levels; CRC cis rs1799949 1.000 rs2175957 chr17:41286822 T/G cg19454999 chr17:41278357 BRCA1;NBR2 0.54 8.44 0.42 9.92e-16 Menopause (age at onset); CRC cis rs3087591 0.879 rs4795591 chr17:29612410 C/A cg24425628 chr17:29625626 OMG;NF1 -0.88 -17.02 -0.68 4.81e-47 Hip circumference; CRC cis rs1448094 0.534 rs11613070 chr12:86167544 T/A cg02569458 chr12:86230093 RASSF9 0.48 8.02 0.4 1.9e-14 Major depressive disorder; CRC cis rs6598955 0.640 rs1577507 chr1:26547179 C/T cg00852783 chr1:26633632 UBXN11 0.44 7.12 0.37 6.79e-12 Obesity-related traits; CRC cis rs172166 0.637 rs1225592 chr6:28150242 G/A cg17949981 chr6:28129498 ZNF389 0.41 5.71 0.3 2.54e-8 Cardiac Troponin-T levels; CRC cis rs7932354 0.528 rs7947878 chr11:47028531 C/T cg03339077 chr11:47165057 C11orf49 0.44 6.26 0.33 1.23e-9 Bone mineral density (hip);Bone mineral density; CRC cis rs1451375 0.617 rs2329366 chr7:50544966 G/A cg14593290 chr7:50529359 DDC -0.62 -8.19 -0.41 5.86e-15 Malaria; CRC cis rs7811142 1.000 rs11773661 chr7:100073069 G/C cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.72 9.6 0.47 2.11e-19 Platelet count; CRC cis rs2882667 0.898 rs2116789 chr5:138394262 G/T cg09476006 chr5:138032270 NA 0.43 7.21 0.37 3.86e-12 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs7202877 0.610 rs1010631 chr16:75328590 C/G cg03315344 chr16:75512273 CHST6 0.51 5.94 0.31 7.34e-9 Type 2 diabetes;Type 1 diabetes; CRC cis rs1218582 0.710 rs7553195 chr1:154837796 T/C cg06221963 chr1:154839813 KCNN3 -0.75 -15.13 -0.64 1.26e-39 Prostate cancer; CRC cis rs2073300 0.609 rs74273791 chr20:23418067 A/T cg12062639 chr20:23401060 NAPB 0.84 7.67 0.39 2.02e-13 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs7756236 0.521 rs6930671 chr6:36625272 T/C cg08179530 chr6:36648295 CDKN1A 0.38 5.63 0.3 3.85e-8 QRS duration; CRC cis rs4731207 0.596 rs9641759 chr7:124666210 C/T cg23710748 chr7:124431027 NA -0.39 -6.09 -0.32 3.23e-9 Cutaneous malignant melanoma; CRC cis rs1218582 0.710 rs7553195 chr1:154837796 T/C cg16680214 chr1:154839983 KCNN3 -0.5 -10.09 -0.49 4.96e-21 Prostate cancer; CRC cis rs67311347 1.000 rs9860162 chr3:40403875 C/T cg24209194 chr3:40518798 ZNF619 0.38 5.66 0.3 3.28e-8 Renal cell carcinoma; CRC cis rs1552244 1.000 rs7622963 chr3:10139825 C/T cg10729496 chr3:10149963 C3orf24 0.49 6.78 0.35 5.57e-11 Alzheimer's disease; CRC cis rs12479064 0.724 rs3792150 chr2:100041849 G/A cg26064155 chr2:99771622 LIPT1;TSGA10 -0.62 -7.78 -0.39 9.76e-14 Chronic sinus infection; CRC cis rs12023718 0.588 rs10913585 chr1:178607694 C/T cg00404053 chr1:178313656 RASAL2 0.6 7.54 0.38 4.56e-13 Obesity-related traits; CRC cis rs6951245 1.000 rs76388414 chr7:1100694 G/A cg24642844 chr7:1081250 C7orf50 -0.76 -9.16 -0.45 5.78e-18 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs950169 0.922 rs2033284 chr15:84946273 C/T cg17507749 chr15:85114479 UBE2QP1 0.74 10.56 0.5 1.24e-22 Schizophrenia; CRC cis rs12134245 0.776 rs12125947 chr1:91990487 T/C cg07090678 chr1:91966139 CDC7 0.41 6.7 0.35 8.82e-11 Breast cancer; CRC cis rs7493 1.000 rs6961773 chr7:95037718 T/G cg01874867 chr7:94954059 PON1 -0.52 -6.54 -0.34 2.29e-10 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs6088580 0.634 rs9789792 chr20:32957709 G/A cg24642439 chr20:33292090 TP53INP2 -0.4 -6.74 -0.35 6.94e-11 Glomerular filtration rate (creatinine); CRC cis rs1691799 0.899 rs1168320 chr12:66744849 C/T cg16791601 chr12:66731901 HELB -0.73 -12.99 -0.58 1.92e-31 White blood cell count (basophil); CRC cis rs6066835 1.000 rs6066815 chr20:47299870 T/C cg18078177 chr20:47281410 PREX1 0.78 5.99 0.31 5.36e-9 Multiple myeloma; CRC cis rs3617 0.573 rs4687680 chr3:52907372 G/A cg05573699 chr3:52720067 GNL3;PBRM1 -0.4 -5.92 -0.31 8.03e-9 Red blood cell count;Autism spectrum disorder or schizophrenia; CRC cis rs6076065 0.723 rs2424545 chr20:23390876 A/G cg11657817 chr20:23433608 CST11 -0.43 -6.26 -0.33 1.19e-9 Facial morphology (factor 15, philtrum width); CRC cis rs11971779 0.616 rs7779314 chr7:139112696 G/C cg07862535 chr7:139043722 LUC7L2 0.57 7.35 0.38 1.61e-12 Diisocyanate-induced asthma; CRC cis rs7635838 0.718 rs2249051 chr3:11403234 G/A cg00170343 chr3:11313890 ATG7 0.46 7.13 0.37 6.55e-12 HDL cholesterol; CRC cis rs17401966 0.964 rs34215045 chr1:10361679 G/A cg19773385 chr1:10388646 KIF1B -0.58 -8.03 -0.4 1.73e-14 Hepatocellular carcinoma; CRC cis rs6496667 0.865 rs8039775 chr15:90883305 C/T cg04176472 chr15:90893244 GABARAPL3 0.56 6.49 0.34 3.13e-10 Rheumatoid arthritis; CRC cis rs10197940 0.510 rs7602715 chr2:152421937 A/G cg06191203 chr2:152266755 RIF1 -0.5 -6.77 -0.35 5.92e-11 Lung cancer; CRC cis rs875971 0.862 rs6978028 chr7:65886300 G/C cg18876405 chr7:65276391 NA 0.54 8.69 0.43 1.77e-16 Aortic root size; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg22577136 chr1:206644165 IKBKE 0.44 6.42 0.33 4.75e-10 Response to antipsychotic treatment; CRC cis rs3741404 0.825 rs60452247 chr11:63981507 G/A cg19465662 chr11:63993652 NUDT22;TRPT1 0.86 14.12 0.61 1.06e-35 Platelet count; CRC trans rs4332037 0.762 rs11770612 chr7:1915493 A/C cg11693508 chr17:37793320 STARD3 0.57 7.08 0.36 8.78e-12 Bipolar disorder; CRC cis rs924607 0.966 rs1621827 chr5:635074 A/G cg04221910 chr5:616842 CEP72 0.41 6.77 0.35 5.99e-11 Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg27316224 chr11:926106 AP2A2 0.37 6.0 0.31 5.21e-9 Liver disease severity in Alagille syndrome; CRC cis rs4970966 0.855 rs11204701 chr1:150662179 A/T cg17724175 chr1:150552817 MCL1 -0.5 -6.23 -0.32 1.45e-9 Granulocyte percentage of myeloid white cells;Monocyte count;Monocyte percentage of white cells; CRC cis rs422249 0.819 rs174605 chr11:61626921 G/T cg00603274 chr11:61596626 FADS2 -0.39 -5.63 -0.3 3.85e-8 Trans fatty acid levels; CRC cis rs17376456 0.597 rs1031423 chr5:93276883 A/G cg09848695 chr5:92956644 FAM172A;MIR2277 -0.48 -6.26 -0.33 1.19e-9 Diabetic retinopathy; CRC cis rs897984 0.762 rs1870293 chr16:30970941 T/C cg00531865 chr16:30841666 NA 0.43 5.96 0.31 6.37e-9 Dementia with Lewy bodies; CRC cis rs7725052 0.609 rs59384771 chr5:40447105 G/C cg09067459 chr5:40385259 NA -0.45 -7.36 -0.38 1.5e-12 Pediatric autoimmune diseases; CRC trans rs11098499 0.738 rs34965784 chr4:120361586 G/C cg25214090 chr10:38739885 LOC399744 0.66 10.46 0.5 2.62e-22 Corneal astigmatism; CRC cis rs12142240 0.667 rs55887761 chr1:46826587 C/A cg14993813 chr1:46806288 NSUN4 -0.49 -6.22 -0.32 1.55e-9 Menopause (age at onset); CRC cis rs9649213 0.593 rs13246843 chr7:98002661 G/T cg08684580 chr7:98029266 BAIAP2L1 -0.32 -5.67 -0.3 3.09e-8 Prostate cancer (SNP x SNP interaction); CRC cis rs1403694 0.695 rs3774291 chr3:186433471 C/T cg04611788 chr3:186434169 KNG1 -0.61 -9.13 -0.45 7.33e-18 Blood protein levels; CRC cis rs2075371 0.865 rs2544172 chr7:133931338 T/C cg20476274 chr7:133979776 SLC35B4 0.74 12.88 0.58 5.07e-31 Mean platelet volume; CRC trans rs7873102 0.702 rs7028020 chr9:38007747 C/T cg23943013 chr5:79551904 SERINC5 -0.42 -6.72 -0.35 8.03e-11 Brain structure; CRC cis rs6456156 0.774 rs6456158 chr6:167528032 A/C cg07513332 chr6:167530253 CCR6 0.46 8.65 0.43 2.29e-16 Primary biliary cholangitis; CRC cis rs2075371 0.965 rs2544216 chr7:133987902 G/A cg20476274 chr7:133979776 SLC35B4 0.82 15.1 0.64 1.62e-39 Mean platelet volume; CRC cis rs4434138 0.594 rs7653028 chr3:52763000 A/T cg18099408 chr3:52552593 STAB1 -0.46 -7.92 -0.4 3.81e-14 Intelligence (multi-trait analysis); CRC cis rs796364 1.000 rs281760 chr2:200787804 A/G cg12253985 chr2:200820533 C2orf60;C2orf47 0.6 6.61 0.34 1.58e-10 Schizophrenia; CRC cis rs4713118 0.539 rs200951 chr6:27835930 A/G cg06470822 chr6:28175283 NA 0.77 10.97 0.52 4.39e-24 Parkinson's disease; CRC cis rs6502050 0.871 rs6502056 chr17:80070912 C/G cg25804541 chr17:80189381 SLC16A3 0.32 6.12 0.32 2.66e-9 Life satisfaction; CRC trans rs8123881 0.733 rs7268466 chr20:15810676 C/T cg19478983 chr7:120590592 ING3 0.57 6.12 0.32 2.61e-9 Body mass index; CRC cis rs6952808 0.609 rs10227517 chr7:1950292 A/T cg02951883 chr7:2050386 MAD1L1 -0.53 -8.69 -0.43 1.76e-16 Bipolar disorder and schizophrenia; CRC trans rs1005277 0.579 rs2505240 chr10:38442419 G/T cg27523141 chr10:43048294 ZNF37B 0.49 7.13 0.37 6.4e-12 Extrinsic epigenetic age acceleration; CRC cis rs9322193 0.923 rs9800736 chr6:149982417 A/G cg07701084 chr6:150067640 NUP43 0.61 9.09 0.45 9.46e-18 Lung cancer; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg26724186 chr19:3676340 PIP5K1C -0.37 -6.13 -0.32 2.54e-9 Liver disease severity in Alagille syndrome; CRC cis rs11212617 0.967 rs227061 chr11:108205329 A/G cg14761454 chr11:108092087 ATM;NPAT 0.43 6.42 0.33 4.71e-10 Response to metformin in type 2 diabetes (glycemic); CRC cis rs459193 1.000 rs30000 chr5:55803533 G/A cg00049729 chr5:55776345 NA 0.39 5.8 0.3 1.58e-8 Coronary artery disease;Type 2 diabetes;Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);Waist-to-hip ratio adjusted for BMI in non-smokers;Waist-to-hip ratio adjusted for BMI (smoking interaction);Waist-to-hip ratio adjusted for body mass index;Waist-hip ratio;Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction); CRC cis rs12472274 0.646 rs35468889 chr2:239090959 G/A cg17459225 chr2:239074497 NA 0.71 8.6 0.43 3.31e-16 Phospholipid levels (plasma); CRC cis rs8067545 0.750 rs9896411 chr17:19987610 A/T cg13482628 chr17:19912719 NA 0.48 7.71 0.39 1.49e-13 Schizophrenia; CRC cis rs1335587 0.518 rs9513904 chr13:102107582 G/A cg03165014 chr13:102106348 ITGBL1 -0.4 -5.88 -0.31 1e-8 Obesity-related traits; CRC trans rs2243480 1.000 rs313820 chr7:65574466 A/C cg10756647 chr7:56101905 PSPH 0.73 7.68 0.39 1.79e-13 Diabetic kidney disease; CRC cis rs4665809 0.590 rs35532350 chr2:26441605 T/C cg26119090 chr2:26468346 HADHA;HADHB -1.06 -15.5 -0.65 4.69e-41 Gut microbiome composition (summer); CRC cis rs10463316 0.894 rs7707745 chr5:150765198 G/T cg03212797 chr5:150827313 SLC36A1 -0.48 -7.6 -0.39 3.08e-13 Metabolite levels (Pyroglutamine); CRC cis rs1799949 1.000 rs8176202 chr17:41230228 G/A cg05368731 chr17:41323189 NBR1 0.66 9.63 0.47 1.68e-19 Menopause (age at onset); CRC cis rs1448094 0.511 rs2405621 chr12:86149336 A/T cg25456477 chr12:86230367 RASSF9 -0.34 -5.85 -0.31 1.2e-8 Major depressive disorder; CRC cis rs8114671 0.562 rs2223881 chr20:33506463 A/C cg07148914 chr20:33460835 GGT7 0.44 7.06 0.36 9.84e-12 Height; CRC cis rs4555082 0.794 rs2735829 chr14:105708472 C/T cg18132624 chr14:105716052 BTBD6;BRF1 -0.51 -8.31 -0.42 2.57e-15 Mean platelet volume;Platelet distribution width; CRC cis rs11711311 0.955 rs12636240 chr3:113391282 A/G cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.52 -6.86 -0.35 3.38e-11 IgG glycosylation; CRC cis rs796364 1.000 rs1658807 chr2:200767512 C/T cg12253985 chr2:200820533 C2orf60;C2orf47 0.61 6.72 0.35 8e-11 Schizophrenia; CRC trans rs1997103 1.000 rs10228182 chr7:55406695 A/T cg20935933 chr6:143382018 AIG1 0.51 6.65 0.34 1.25e-10 QRS interval (sulfonylurea treatment interaction); CRC cis rs3091242 0.933 rs35497030 chr1:25783066 A/G cg20684491 chr1:25596433 NA -0.44 -7.51 -0.38 5.5e-13 Erythrocyte sedimentation rate; CRC cis rs11758351 0.660 rs77130538 chr6:26210723 T/C cg01420254 chr6:26195488 NA 0.79 8.84 0.44 6.05e-17 Gout;Renal underexcretion gout; CRC trans rs10504229 0.906 rs73607868 chr8:58172482 T/C cg04077850 chr5:125800366 GRAMD3 0.37 6.27 0.33 1.15e-9 Developmental language disorder (linguistic errors); CRC cis rs7814319 0.966 rs10955069 chr8:97253788 C/T cg20787634 chr8:97240163 UQCRB -0.56 -9.86 -0.48 2.94e-20 Lung function (FVC); CRC cis rs12291225 0.679 rs7934671 chr11:14305101 C/T cg05501817 chr11:14380813 RRAS2 -0.46 -6.09 -0.32 3.17e-9 Sense of smell; CRC cis rs7833986 0.501 rs2976038 chr8:57028864 G/A cg23139584 chr8:56987506 RPS20;SNORD54 0.91 12.31 0.56 6.9e-29 Height; CRC cis rs72781680 0.898 rs12623333 chr2:24111823 T/G cg08917208 chr2:24149416 ATAD2B 0.89 8.89 0.44 4.11e-17 Lymphocyte counts; CRC cis rs62064224 0.714 rs16967266 chr17:30632274 G/A cg21839984 chr17:30846986 MYO1D -0.34 -5.88 -0.31 1e-8 Schizophrenia; CRC cis rs7615952 0.599 rs66532274 chr3:125731845 G/A cg15145296 chr3:125709740 NA -0.54 -7.02 -0.36 1.3e-11 Blood pressure (smoking interaction); CRC trans rs4263408 0.934 rs9683743 chr4:39703194 A/C cg16062480 chr1:220219722 EPRS -0.44 -6.53 -0.34 2.48e-10 Plasma amyloid beta peptide concentrations (ABx-40); CRC cis rs972578 1.000 rs4820500 chr22:43379373 C/G cg01576275 chr22:43409880 NA -0.46 -7.28 -0.37 2.52e-12 Mean platelet volume; CRC cis rs4713118 0.696 rs2394002 chr6:27748015 G/A cg03623178 chr6:28175578 NA 0.71 9.38 0.46 1.11e-18 Parkinson's disease; CRC cis rs7647973 0.769 rs4974081 chr3:49070499 A/G cg07636037 chr3:49044803 WDR6 -0.84 -10.77 -0.51 2.19e-23 Menarche (age at onset); CRC cis rs6860806 0.507 rs200837 chr5:131699958 G/A cg12564285 chr5:131593104 PDLIM4 0.45 7.5 0.38 5.81e-13 Breast cancer; CRC cis rs4727027 0.870 rs11524138 chr7:148799125 G/A cg23583168 chr7:148888333 NA -0.92 -15.64 -0.65 1.34e-41 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC cis rs7772486 0.754 rs6570703 chr6:145957052 C/T cg23711669 chr6:146136114 FBXO30 0.67 11.1 0.52 1.62e-24 Lobe attachment (rater-scored or self-reported); CRC cis rs11212617 1.000 rs600931 chr11:108117335 C/T cg01991180 chr11:108092276 ATM;NPAT 0.43 6.26 0.33 1.23e-9 Response to metformin in type 2 diabetes (glycemic); CRC cis rs7615952 0.512 rs2979351 chr3:125363599 C/T cg11143507 chr3:125485238 NA -0.58 -7.43 -0.38 9.65e-13 Blood pressure (smoking interaction); CRC cis rs10504229 0.683 rs16921843 chr8:58113338 T/C cg02290350 chr8:58132656 NA -0.58 -8.24 -0.41 4.09e-15 Developmental language disorder (linguistic errors); CRC cis rs6598163 0.517 rs10902453 chr12:132297091 G/T cg22244940 chr12:132335942 MMP17 -0.4 -6.09 -0.32 3.14e-9 Migraine; CRC cis rs9435341 0.896 rs1623927 chr1:107596120 T/C cg14828511 chr1:107599125 PRMT6 -0.56 -7.65 -0.39 2.3e-13 Facial morphology (factor 21, depth of nasal alae); CRC cis rs7811142 0.830 rs6979910 chr7:99940630 A/C cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.02 14.09 0.61 1.36e-35 Platelet count; CRC cis rs6570726 1.000 rs404229 chr6:145868200 G/A cg23711669 chr6:146136114 FBXO30 0.72 12.48 0.57 1.58e-29 Lobe attachment (rater-scored or self-reported); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg23540765 chr19:1173635 SBNO2 0.41 6.73 0.35 7.66e-11 Liver disease severity in Alagille syndrome; CRC cis rs3806843 1.000 rs2337985 chr5:140157861 T/C cg16607685 chr5:140181889 PCDHA2;PCDHA1;PCDHA3 -0.26 -5.92 -0.31 8.06e-9 Depressive symptoms (multi-trait analysis); CRC cis rs6662572 0.906 rs76438782 chr1:46240425 C/A cg08644498 chr1:46502608 NA 0.47 7.53 0.38 5.05e-13 Blood protein levels; CRC cis rs9858542 1.000 rs4283605 chr3:49678651 A/G cg03060546 chr3:49711283 APEH -0.5 -6.75 -0.35 6.6e-11 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs6604026 0.630 rs35807969 chr1:93459069 T/A cg17283838 chr1:93427260 FAM69A 0.46 5.97 0.31 6.21e-9 Multiple sclerosis; CRC cis rs8067545 0.611 rs2526482 chr17:20119133 C/T cg13482628 chr17:19912719 NA -0.46 -7.3 -0.37 2.19e-12 Schizophrenia; CRC cis rs898097 1.000 rs898097 chr17:80904310 C/T cg15369054 chr17:80825471 TBCD -0.42 -6.87 -0.35 3.26e-11 Breast cancer; CRC cis rs6840360 0.642 rs2709831 chr4:152379651 G/A cg09659197 chr4:152720779 NA 0.33 6.61 0.34 1.57e-10 Intelligence (multi-trait analysis); CRC trans rs2243480 1.000 rs316334 chr7:65602126 G/T cg10756647 chr7:56101905 PSPH 0.74 7.72 0.39 1.43e-13 Diabetic kidney disease; CRC cis rs9868809 0.881 rs13096357 chr3:48675856 C/A cg00383909 chr3:49044727 WDR6 0.66 6.61 0.34 1.53e-10 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; CRC cis rs6951245 0.554 rs11544331 chr7:1131411 C/T cg23978390 chr7:1156363 C7orf50 0.52 5.76 0.3 1.98e-8 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs9303401 0.659 rs34556735 chr17:56694447 A/C cg10487724 chr17:56770010 TEX14;RAD51C 0.8 9.24 0.45 3.17e-18 Cognitive test performance; CRC cis rs1799949 1.000 rs2271573 chr17:41327621 A/G cg19454999 chr17:41278357 BRCA1;NBR2 0.54 8.21 0.41 5.03e-15 Menopause (age at onset); CRC cis rs597539 0.652 rs501799 chr11:68631240 G/T cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.86 15.28 0.64 3.24e-40 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs10924970 0.967 rs2382615 chr1:235454955 G/A cg26050004 chr1:235667680 B3GALNT2 0.4 5.98 0.31 5.81e-9 Asthma; CRC cis rs7246657 0.943 rs7255785 chr19:37971683 C/T cg23950597 chr19:37808831 NA -0.49 -6.06 -0.32 3.8e-9 Coronary artery calcification; CRC cis rs1046896 0.538 rs3803771 chr17:80687758 G/A cg03115019 chr17:80708279 FN3K -0.36 -5.98 -0.31 5.69e-9 Glycated hemoglobin levels; CRC cis rs34375054 0.624 rs12580033 chr12:125676083 A/T cg02766259 chr12:125626809 AACS -0.48 -7.73 -0.39 1.29e-13 Post bronchodilator FEV1/FVC ratio; CRC cis rs2282802 0.685 rs7737543 chr5:139646026 A/G cg26211634 chr5:139558579 C5orf32 0.43 7.39 0.38 1.26e-12 Intelligence (multi-trait analysis); CRC cis rs10791323 0.582 rs2851120 chr11:133708065 A/G cg15485101 chr11:133734466 NA 0.44 7.57 0.38 3.9e-13 Childhood ear infection; CRC cis rs16975963 0.843 rs73027451 chr19:38375666 C/T cg15135657 chr19:38346511 NA -0.42 -5.66 -0.3 3.26e-8 Longevity; CRC cis rs10504229 0.639 rs35527749 chr8:58128077 G/T cg22535103 chr8:58192502 C8orf71 -0.8 -8.99 -0.44 2.05e-17 Developmental language disorder (linguistic errors); CRC cis rs6570726 0.967 rs1396648 chr6:145785248 C/A cg05347473 chr6:146136440 FBXO30 -0.37 -5.85 -0.31 1.18e-8 Lobe attachment (rater-scored or self-reported); CRC cis rs6952808 0.723 rs1107592 chr7:2041432 C/T cg19624444 chr7:2048497 MAD1L1 -0.31 -5.63 -0.3 3.78e-8 Bipolar disorder and schizophrenia; CRC cis rs11098499 0.675 rs11098534 chr4:120556772 T/G cg24375607 chr4:120327624 NA 0.47 7.37 0.38 1.36e-12 Corneal astigmatism; CRC cis rs172166 0.694 rs203877 chr6:28048624 T/C cg25164649 chr6:28176230 NA 0.6 8.64 0.43 2.5e-16 Cardiac Troponin-T levels; CRC cis rs10463316 0.817 rs10040628 chr5:150821027 T/G cg03212797 chr5:150827313 SLC36A1 -0.48 -7.44 -0.38 8.65e-13 Metabolite levels (Pyroglutamine); CRC cis rs7725052 0.609 rs4496750 chr5:40452993 G/C cg09067459 chr5:40385259 NA -0.4 -6.68 -0.35 9.91e-11 Pediatric autoimmune diseases; CRC trans rs2303319 0.504 rs12470743 chr2:162611202 G/A cg25193742 chr10:104614220 C10orf32 -0.77 -6.51 -0.34 2.87e-10 Cognitive function; CRC cis rs1448094 0.533 rs7307617 chr12:86151317 T/C cg02569458 chr12:86230093 RASSF9 -0.48 -7.97 -0.4 2.72e-14 Major depressive disorder; CRC cis rs2811415 0.597 rs998392 chr3:127768329 A/G cg13719885 chr3:127795394 NA -0.37 -5.65 -0.3 3.49e-8 Lung function (FEV1/FVC); CRC cis rs651907 0.535 rs1460097 chr3:101497569 C/T cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.59 7.89 0.4 4.58e-14 Colorectal cancer; CRC cis rs453301 0.522 rs1964356 chr8:8853270 G/T cg08975724 chr8:8085496 FLJ10661 0.39 5.73 0.3 2.28e-8 Joint mobility (Beighton score); CRC cis rs9911578 0.967 rs11656413 chr17:57082013 A/C cg05425664 chr17:57184151 TRIM37 0.53 8.47 0.42 8.53e-16 Intelligence (multi-trait analysis); CRC cis rs911555 0.755 rs2756132 chr14:103967820 C/G cg12935359 chr14:103987150 CKB 0.56 8.95 0.44 2.7e-17 Intelligence (multi-trait analysis); CRC cis rs10504229 0.679 rs56040464 chr8:58131603 G/A cg02725872 chr8:58115012 NA -0.64 -11.55 -0.54 3.85e-26 Developmental language disorder (linguistic errors); CRC cis rs2180341 0.889 rs2000909 chr6:127711173 G/A cg27446573 chr6:127587934 RNF146 0.7 9.69 0.47 1.09e-19 Breast cancer; CRC cis rs11122272 0.735 rs2790876 chr1:231536033 C/T cg06096015 chr1:231504339 EGLN1 0.41 6.11 0.32 2.88e-9 Hemoglobin concentration; CRC cis rs4566357 0.615 rs10198214 chr2:227913314 A/C cg11843606 chr2:227700838 RHBDD1 -0.44 -6.85 -0.35 3.54e-11 Coronary artery disease; CRC cis rs2839186 0.814 rs12482209 chr21:47664275 C/G cg13126279 chr21:47581558 C21orf56 0.48 7.84 0.4 6.5e-14 Testicular germ cell tumor; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg14223017 chr19:2151266 AP3D1 0.45 7.16 0.37 5.31e-12 Liver disease severity in Alagille syndrome; CRC cis rs1832871 0.672 rs11751081 chr6:158761505 G/A cg07165851 chr6:158734300 TULP4 0.62 7.89 0.4 4.38e-14 Height; CRC cis rs11955398 0.647 rs57521726 chr5:59984897 A/T cg02684056 chr5:59996105 DEPDC1B 0.4 5.85 0.31 1.21e-8 Intelligence (multi-trait analysis); CRC cis rs6860806 0.661 rs334902 chr5:131586559 C/G cg11843238 chr5:131593191 PDLIM4 0.42 7.8 0.4 8.18e-14 Breast cancer; CRC cis rs875971 0.862 rs10278014 chr7:66051264 C/T cg11764359 chr7:65958608 NA -0.59 -8.88 -0.44 4.53e-17 Aortic root size; CRC cis rs6541297 1.000 rs6682741 chr1:230279090 T/C cg05784532 chr1:230284198 GALNT2 0.44 6.2 0.32 1.65e-9 Coronary artery disease; CRC cis rs7215564 0.908 rs35253080 chr17:78700167 G/A cg09596252 chr17:78655493 RPTOR 0.6 6.22 0.32 1.51e-9 Myopia (pathological); CRC trans rs7618501 0.521 rs952594 chr3:49908023 G/A cg21659725 chr3:3221576 CRBN 0.53 7.82 0.4 7.03e-14 Intelligence (multi-trait analysis); CRC cis rs977987 0.527 rs62059844 chr16:75429737 T/C cg03315344 chr16:75512273 CHST6 0.54 9.0 0.44 1.86e-17 Dupuytren's disease; CRC cis rs12451471 0.620 rs11150846 chr17:78098520 C/T cg08347473 chr17:78092826 GAA -0.35 -5.82 -0.31 1.43e-8 Plateletcrit;Mean corpuscular hemoglobin concentration; CRC cis rs12477438 1.000 rs57846982 chr2:99921574 A/C cg26064155 chr2:99771622 LIPT1;TSGA10 -0.8 -9.59 -0.47 2.24e-19 Chronic sinus infection; CRC cis rs5758659 0.652 rs5758553 chr22:42431429 G/A cg04733989 chr22:42467013 NAGA 0.41 5.81 0.3 1.51e-8 Cognitive function; CRC cis rs12477438 0.765 rs7605734 chr2:99644068 G/A cg26064155 chr2:99771622 LIPT1;TSGA10 -0.63 -8.55 -0.43 4.57e-16 Chronic sinus infection; CRC cis rs9527 0.615 rs7089065 chr10:104723022 C/T cg15744005 chr10:104629667 AS3MT -0.31 -6.23 -0.32 1.41e-9 Arsenic metabolism; CRC cis rs9463078 0.838 rs9395066 chr6:45095163 A/C cg25276700 chr6:44698697 NA -0.28 -6.81 -0.35 4.55e-11 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; CRC cis rs7107174 0.892 rs2512519 chr11:77953015 C/T cg02023728 chr11:77925099 USP35 0.52 8.08 0.41 1.27e-14 Testicular germ cell tumor; CRC cis rs6539267 0.741 rs10861572 chr12:106688576 A/G cg00173435 chr12:106696525 TCP11L2 -0.51 -6.8 -0.35 5e-11 Tourette syndrome; CRC cis rs7647973 1.000 rs62259944 chr3:49430883 G/A cg07636037 chr3:49044803 WDR6 -0.62 -7.13 -0.37 6.47e-12 Menarche (age at onset); CRC cis rs2836974 0.899 rs6517514 chr21:40527095 G/T cg06238570 chr21:40685208 BRWD1 0.71 10.1 0.49 4.5e-21 Cognitive function; CRC cis rs6912958 0.512 rs910563 chr6:88058885 G/A cg08069147 chr6:88032118 GJB7;C6orf162 0.68 11.07 0.52 1.98e-24 Monocyte percentage of white cells; CRC cis rs2932538 0.922 rs6691917 chr1:113137043 G/C cg22162597 chr1:113214053 CAPZA1 0.61 9.06 0.45 1.15e-17 Systolic blood pressure;Diastolic blood pressure;Hypertension;Blood pressure; CRC cis rs11123170 0.542 rs11123169 chr2:113967075 C/T cg19083407 chr2:113993142 PAX8;LOC440839;LOC654433 -0.44 -5.93 -0.31 7.75e-9 Renal function-related traits (BUN); CRC cis rs1018836 0.545 rs4236827 chr8:91688943 A/T cg16814680 chr8:91681699 NA -0.92 -19.6 -0.73 3.23e-57 Ejection fraction in Tripanosoma cruzi seropositivity; CRC cis rs11098499 0.779 rs6815934 chr4:120267310 T/C cg09307838 chr4:120376055 NA 0.62 9.69 0.47 1.07e-19 Corneal astigmatism; CRC cis rs910316 0.874 rs61980828 chr14:75630378 G/A cg11812906 chr14:75593930 NEK9 -0.65 -10.22 -0.49 1.83e-21 Height; CRC cis rs7727544 0.735 rs272894 chr5:131662460 C/T cg07395648 chr5:131743802 NA -0.39 -6.23 -0.33 1.39e-9 Blood metabolite levels; CRC cis rs514406 0.667 rs10788942 chr1:53210521 A/T cg25767906 chr1:53392781 SCP2 0.36 5.79 0.3 1.63e-8 Monocyte count; CRC cis rs7647973 0.626 rs1352889 chr3:49652148 T/C cg13072238 chr3:49761600 GMPPB -0.51 -5.96 -0.31 6.64e-9 Menarche (age at onset); CRC trans rs7618501 0.516 rs2856236 chr3:50161717 A/C cg21665057 chr3:196295764 WDR53;FBXO45 -0.53 -8.02 -0.4 1.88e-14 Intelligence (multi-trait analysis); CRC trans rs10982213 0.830 rs2274163 chr9:117188714 C/T cg15113064 chr3:124774855 HEG1 0.4 6.11 0.32 2.82e-9 Interleukin-6 levels; CRC cis rs1801251 1.000 rs2592105 chr2:233645968 C/G cg25237894 chr2:233734115 C2orf82 0.54 8.58 0.43 3.75e-16 Coronary artery disease; CRC trans rs944990 0.595 rs10123378 chr9:96375217 C/T cg11586124 chr12:58259160 NA 0.38 6.05 0.32 3.88e-9 Body mass index; CRC cis rs853679 0.699 rs9468318 chr6:28209531 T/A cg12273811 chr6:28175739 NA 0.55 5.86 0.31 1.12e-8 Depression; CRC cis rs11711311 1.000 rs12632983 chr3:113481913 A/C cg15478005 chr3:113465772 ATP6V1A;NAA50 0.42 5.87 0.31 1.08e-8 IgG glycosylation; CRC cis rs7647973 0.626 rs2329021 chr3:49679072 G/A cg13072238 chr3:49761600 GMPPB -0.52 -5.92 -0.31 8.06e-9 Menarche (age at onset); CRC cis rs6951245 0.872 rs76713558 chr7:1095866 A/G cg18402987 chr7:1209562 NA 0.67 7.15 0.37 5.54e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs9816226 0.591 rs10513801 chr3:185822353 T/G cg00760338 chr3:185826511 ETV5 -0.71 -5.84 -0.31 1.23e-8 Obesity;Body mass index; CRC cis rs802075 1.000 rs360559 chr6:49659871 A/C cg20364632 chr6:49636226 NA -0.36 -5.87 -0.31 1.05e-8 Bone mineral density (hip) and age at menarche; CRC cis rs4819052 0.851 rs4819040 chr21:46659762 T/C cg19498844 chr21:46707878 POFUT2;LOC642852 0.64 9.44 0.46 7.27e-19 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg21250466 chr4:854474 GAK -0.38 -5.99 -0.31 5.59e-9 Liver disease severity in Alagille syndrome; CRC cis rs6831352 0.734 rs3018046 chr4:100030388 C/T cg13256891 chr4:100009986 ADH5 0.57 7.9 0.4 4.36e-14 Alcohol dependence; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg13063040 chr8:145669623 NFKBIL2 0.45 7.42 0.38 9.91e-13 Liver disease severity in Alagille syndrome; CRC cis rs2019137 0.836 rs4848318 chr2:113953952 T/C cg19083407 chr2:113993142 PAX8;LOC440839;LOC654433 -0.47 -6.56 -0.34 2.04e-10 Lymphocyte counts; CRC cis rs7659604 0.540 rs10004284 chr4:122699222 A/T cg19748678 chr4:122722346 EXOSC9 -0.42 -5.72 -0.3 2.4e-8 Type 2 diabetes; CRC cis rs3820068 0.705 rs72643701 chr1:15866219 G/A cg27534772 chr1:16042836 PLEKHM2 0.44 7.44 0.38 8.59e-13 Systolic blood pressure; CRC cis rs752010 0.523 rs10890158 chr1:42117985 C/T cg06885757 chr1:42089581 HIVEP3 0.36 6.07 0.32 3.58e-9 Lupus nephritis in systemic lupus erythematosus; CRC cis rs6951245 0.935 rs112554101 chr7:1065535 A/G cg24642844 chr7:1081250 C7orf50 -0.58 -7.62 -0.39 2.65e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC trans rs1814175 0.754 rs10839453 chr11:49955815 A/T cg15704280 chr7:45808275 SEPT13 -1.02 -20.62 -0.75 3.25e-61 Height; CRC trans rs10242455 0.702 rs59574285 chr7:99236151 C/T cg09045935 chr12:6379348 NA 0.92 6.84 0.35 3.8e-11 Blood metabolite levels; CRC cis rs7044106 0.791 rs10985008 chr9:123492960 G/A cg14255062 chr9:123606675 PSMD5;LOC253039 0.5 7.58 0.39 3.61e-13 Hip circumference adjusted for BMI; CRC cis rs6088580 0.602 rs6059834 chr20:33019299 A/G cg08999081 chr20:33150536 PIGU 0.61 11.58 0.54 3.11e-26 Glomerular filtration rate (creatinine); CRC cis rs10791097 0.694 rs12361892 chr11:130744490 T/G cg12179176 chr11:130786555 SNX19 0.75 12.66 0.57 3.28e-30 Autism spectrum disorder or schizophrenia;Schizophrenia; CRC cis rs12618769 0.597 rs3754879 chr2:99164541 G/T cg18455616 chr2:99124870 INPP4A 0.36 5.92 0.31 8.23e-9 Bipolar disorder; CRC cis rs6582630 0.638 rs61931383 chr12:38513845 G/A cg26384229 chr12:38710491 ALG10B -0.52 -7.54 -0.38 4.68e-13 Drug-induced liver injury (flucloxacillin); CRC cis rs13191362 1.000 rs36113695 chr6:163004733 T/A cg21926612 chr6:163149169 PACRG;PARK2 0.8 11.15 0.52 1.08e-24 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs13256369 0.774 rs13260303 chr8:8587342 A/C cg18904891 chr8:8559673 CLDN23 0.55 7.65 0.39 2.18e-13 Obesity-related traits; CRC cis rs2228479 0.850 rs11076623 chr16:89844120 G/T cg06558623 chr16:89946397 TCF25 1.09 10.23 0.49 1.69e-21 Skin colour saturation; CRC cis rs9910055 0.664 rs433610 chr17:42197281 A/G cg19774624 chr17:42201019 HDAC5 0.65 9.52 0.46 3.85e-19 Total body bone mineral density; CRC cis rs7647973 0.961 rs4955443 chr3:49286618 T/G cg07636037 chr3:49044803 WDR6 0.62 7.6 0.39 3.2e-13 Menarche (age at onset); CRC cis rs4481887 0.927 rs6671702 chr1:248482851 G/A cg13385794 chr1:248469461 NA 0.4 7.11 0.36 7.23e-12 Common traits (Other); CRC cis rs10876993 0.928 rs2928053 chr12:58063475 T/C cg18357645 chr12:58087776 OS9 0.6 8.52 0.42 6.01e-16 Celiac disease or Rheumatoid arthritis; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg16226300 chr6:133136135 RPS12;SNORD101 0.46 7.23 0.37 3.44e-12 Liver disease severity in Alagille syndrome; CRC cis rs67340775 0.541 rs169287 chr6:27854760 C/A cg12273811 chr6:28175739 NA 0.58 6.02 0.31 4.78e-9 Lung cancer in ever smokers; CRC trans rs62103177 0.810 rs62103192 chr18:77629050 A/T cg05926928 chr17:57297772 GDPD1 1.06 9.98 0.48 1.12e-20 Opioid sensitivity; CRC cis rs3764400 0.567 rs12946208 chr17:46312129 G/A cg10706073 chr17:46328419 SKAP1 -0.61 -6.65 -0.34 1.23e-10 Body mass index; CRC cis rs2204008 0.837 rs2127955 chr12:37969194 A/G cg13010199 chr12:38710504 ALG10B 0.47 6.93 0.36 2.24e-11 Bladder cancer; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg14699228 chr3:49823994 IP6K1 0.36 6.12 0.32 2.71e-9 Liver disease severity in Alagille syndrome; CRC cis rs9488822 0.636 rs11153592 chr6:116330574 T/C cg15226275 chr6:116381976 FRK 0.3 8.52 0.42 6e-16 Cholesterol, total;LDL cholesterol; CRC trans rs11039798 0.588 rs10838970 chr11:48606267 G/T cg15704280 chr7:45808275 SEPT13 0.65 6.93 0.36 2.21e-11 Axial length; CRC cis rs2635047 0.777 rs9944807 chr18:44788908 A/G cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.36 5.62 0.3 4.01e-8 Educational attainment; CRC cis rs1215050 0.755 rs7696354 chr4:98820330 T/C cg05340658 chr4:99064831 C4orf37 0.49 7.08 0.36 8.86e-12 Waist-to-hip ratio adjusted for body mass index; CRC cis rs6952808 0.965 rs4719318 chr7:1887930 G/A cg00106254 chr7:1943704 MAD1L1 -0.42 -6.22 -0.32 1.47e-9 Bipolar disorder and schizophrenia; CRC cis rs10256972 0.567 rs2949185 chr7:1209013 A/G cg03923535 chr7:1197113 ZFAND2A 0.76 11.65 0.54 1.65e-26 Longevity;Endometriosis; CRC cis rs7520050 0.553 rs2993263 chr1:46021630 A/G cg15605315 chr1:45957053 TESK2 -0.39 -6.11 -0.32 2.79e-9 Red blood cell count;Reticulocyte count; CRC trans rs1005277 0.579 rs2474575 chr10:38387901 C/T cg17830980 chr10:43048298 ZNF37B -0.6 -9.96 -0.48 1.3e-20 Extrinsic epigenetic age acceleration; CRC cis rs7772486 0.875 rs13204280 chr6:146415368 T/C cg23711669 chr6:146136114 FBXO30 0.64 10.94 0.52 5.92e-24 Lobe attachment (rater-scored or self-reported); CRC cis rs9547692 1.000 rs527929 chr13:37478506 C/T cg01493522 chr13:37497338 NA -0.5 -6.9 -0.36 2.73e-11 Coronary artery disease; CRC trans rs561341 0.714 rs111760509 chr17:30304320 A/G cg27661571 chr11:113659931 NA -0.94 -10.89 -0.51 8.63e-24 Hip circumference adjusted for BMI; CRC cis rs9403521 1.000 rs6915784 chr6:143984268 A/C cg18240653 chr6:144019428 PHACTR2 -0.49 -5.79 -0.3 1.61e-8 Obesity-related traits; CRC cis rs4665809 0.652 rs6727974 chr2:26524639 A/G cg22920501 chr2:26401640 FAM59B 0.59 8.46 0.42 8.83e-16 Gut microbiome composition (summer); CRC cis rs853679 0.517 rs2275508 chr6:28094731 T/C cg15845792 chr6:28175446 NA 0.99 13.41 0.59 5.26e-33 Depression; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg14825729 chr4:147866863 TTC29 0.36 6.63 0.34 1.39e-10 Liver disease severity in Alagille syndrome; CRC cis rs57221529 0.766 rs4245972 chr5:578572 A/G cg17948913 chr5:572064 NA 0.56 6.25 0.33 1.28e-9 Lung disease severity in cystic fibrosis; CRC cis rs28386778 0.897 rs894413 chr17:61916347 A/G cg25654072 chr17:61904446 PSMC5;FTSJ3 0.72 11.16 0.52 9.37e-25 Prudent dietary pattern; CRC cis rs225245 0.782 rs321617 chr17:33915246 A/G cg05299278 chr17:33885742 SLFN14 0.48 7.91 0.4 3.98e-14 Reticulocyte count;Reticulocyte fraction of red cells;High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg15065896 chr3:37285038 GOLGA4 0.47 6.73 0.35 7.49e-11 Response to antipsychotic treatment; CRC cis rs7193541 1.000 rs7193541 chr16:74664743 C/T cg01733217 chr16:74700730 RFWD3 -0.85 -15.77 -0.66 4.18e-42 Multiple myeloma; CRC cis rs477692 0.935 rs554458 chr10:131427372 A/G cg05714579 chr10:131428358 MGMT 0.61 8.94 0.44 2.9e-17 Response to temozolomide; CRC cis rs1552244 0.882 rs56224841 chr3:10044014 A/C cg13047869 chr3:10149882 C3orf24 0.51 6.97 0.36 1.74e-11 Alzheimer's disease; CRC cis rs9911578 1.000 rs12449365 chr17:56600660 C/G cg12560992 chr17:57184187 TRIM37 -0.91 -17.1 -0.69 2.31e-47 Intelligence (multi-trait analysis); CRC cis rs1475911 0.507 rs11702347 chr21:43526454 C/T cg19766460 chr21:43528205 UMODL1;C21orf128 1.23 17.7 0.7 1.06e-49 IgG glycosylation; CRC trans rs9341835 0.772 rs9449233 chr6:64138234 G/T cg13657004 chr13:50234944 EBPL -0.37 -6.22 -0.32 1.48e-9 Schizophrenia; CRC cis rs6426558 0.537 rs689094 chr1:227308909 G/A cg10327440 chr1:227177885 CDC42BPA 0.45 6.79 0.35 5.1e-11 Neutrophil percentage of white cells; CRC trans rs1814175 0.645 rs11040699 chr11:50023798 C/G cg15704280 chr7:45808275 SEPT13 -0.92 -16.92 -0.68 1.2e-46 Height; CRC cis rs1941023 0.503 rs4528348 chr11:60129505 C/G cg08716584 chr11:60157161 MS4A7 -0.52 -8.73 -0.43 1.35e-16 Congenital heart disease (maternal effect); CRC cis rs4727027 0.835 rs11767810 chr7:148774433 T/A cg12479418 chr7:148823350 ZNF425;ZNF398 0.44 6.07 0.32 3.62e-9 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC cis rs2839186 0.708 rs6518285 chr21:47644667 T/C cg26721908 chr21:47610096 LSS -0.41 -6.46 -0.34 3.83e-10 Testicular germ cell tumor; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg22769031 chr20:35580195 SAMHD1 0.44 6.28 0.33 1.08e-9 Response to antipsychotic treatment; CRC cis rs672059 1.000 rs546183 chr1:183157753 A/G ch.1.3577855R chr1:183094577 LAMC1 0.5 7.29 0.37 2.38e-12 Hypertriglyceridemia; CRC cis rs12681288 0.823 rs2701903 chr8:1004029 A/G cg15309053 chr8:964076 NA -0.35 -6.65 -0.34 1.25e-10 Schizophrenia; CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg27343303 chr11:34380546 NA -0.49 -6.22 -0.32 1.49e-9 Diisocyanate-induced asthma; CRC trans rs61101201 0.962 rs10835790 chr11:31610022 C/T cg14190817 chr9:128003556 HSPA5 -0.5 -5.99 -0.31 5.63e-9 Optic disc area; CRC cis rs17067123 0.614 rs1036767 chr4:180068417 G/A cg26610307 chr4:180072759 NA -0.56 -6.76 -0.35 6.47e-11 Response to hepatitis C treatment; CRC cis rs28386778 0.831 rs2584618 chr17:61923611 T/C cg25654072 chr17:61904446 PSMC5;FTSJ3 0.72 11.19 0.52 7.76e-25 Prudent dietary pattern; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg15397725 chr14:53019133 TXNDC16;GPR137C 0.5 7.12 0.37 6.67e-12 Response to antipsychotic treatment; CRC cis rs9926296 0.509 rs2159113 chr16:89832083 C/T cg03388025 chr16:89894329 SPIRE2 0.36 6.88 0.35 3.11e-11 Vitiligo; CRC cis rs1862618 0.853 rs11739344 chr5:56111087 A/C cg18230493 chr5:56204884 C5orf35 -0.74 -9.38 -0.46 1.14e-18 Initial pursuit acceleration; CRC cis rs898097 0.585 rs9893200 chr17:80893028 A/C cg10494973 chr17:80897199 TBCD -0.38 -5.92 -0.31 7.93e-9 Breast cancer; CRC cis rs10751667 1.000 rs10794357 chr11:973374 T/C cg23136738 chr11:925521 AP2A2 -0.51 -8.17 -0.41 6.77e-15 Alzheimer's disease (late onset); CRC cis rs11628318 0.614 rs62007936 chr14:103198740 G/A cg23461800 chr14:103021989 NA 0.68 7.36 0.38 1.46e-12 Platelet count; CRC cis rs2404602 0.692 rs12910382 chr15:77053442 A/C cg22467129 chr15:76604101 ETFA -0.4 -6.59 -0.34 1.78e-10 Blood metabolite levels; CRC cis rs7949030 0.626 rs1061093 chr11:62334908 G/C cg22862634 chr11:62369728 EML3;MTA2 0.58 10.33 0.49 7.43e-22 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; CRC cis rs748404 0.697 rs554001 chr15:43551919 G/A cg02155558 chr15:43621948 ADAL;LCMT2 0.43 6.44 0.33 4.12e-10 Lung cancer; CRC trans rs7819412 0.668 rs4841507 chr8:11046394 C/G cg06636001 chr8:8085503 FLJ10661 -0.49 -7.49 -0.38 6.42e-13 Triglycerides; CRC cis rs1580019 0.568 rs2122633 chr7:32523870 G/T cg06627557 chr7:32535165 LSM5;AVL9 0.98 18.53 0.71 5.55e-53 Cognitive ability; CRC cis rs6662572 0.737 rs7512448 chr1:46449291 A/G cg08644498 chr1:46502608 NA -0.46 -7.3 -0.37 2.16e-12 Blood protein levels; CRC cis rs889312 0.500 rs832585 chr5:56125904 T/C cg20203395 chr5:56204925 C5orf35 -0.4 -5.65 -0.3 3.51e-8 Breast cancer;Breast cancer (early onset); CRC cis rs6967414 0.786 rs9639026 chr7:6746736 A/G cg00387323 chr7:6746715 ZNF12 0.61 6.03 0.32 4.31e-9 Hematocrit;Hemoglobin concentration; CRC trans rs8108034 1.000 rs39587 chr19:39806997 C/T cg20807030 chr8:67525572 MYBL1 -0.58 -6.37 -0.33 6.46e-10 Lung adenocarcinoma; CRC cis rs6952808 0.782 rs4236271 chr7:1881369 C/T cg02951883 chr7:2050386 MAD1L1 -0.57 -9.24 -0.45 3.18e-18 Bipolar disorder and schizophrenia; CRC cis rs8060686 1.000 rs8060686 chr16:67911517 T/C cg00318322 chr16:67708822 GFOD2 -0.3 -5.74 -0.3 2.11e-8 HDL cholesterol;Metabolic syndrome; CRC cis rs10504229 0.953 rs75585481 chr8:58192202 T/C cg02725872 chr8:58115012 NA -0.38 -6.43 -0.33 4.44e-10 Developmental language disorder (linguistic errors); CRC cis rs10779751 0.770 rs11585553 chr1:11233814 G/A cg08854313 chr1:11322531 MTOR -0.66 -7.74 -0.39 1.21e-13 Body mass index; CRC cis rs7508679 1.000 rs10410204 chr19:7224350 C/T cg00428638 chr19:7224713 INSR 0.98 20.42 0.75 1.98e-60 Hypothyroidism; CRC cis rs4713118 0.597 rs172166 chr6:28020820 C/G cg12172441 chr6:28176163 NA 0.54 6.99 0.36 1.58e-11 Parkinson's disease; CRC cis rs6570726 0.791 rs9376953 chr6:145912226 G/T cg05347473 chr6:146136440 FBXO30 0.39 5.89 0.31 9.49e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs2836974 0.613 rs2245455 chr21:40548087 A/T cg11644478 chr21:40555479 PSMG1 -0.66 -10.68 -0.51 4.84e-23 Cognitive function; CRC cis rs2274273 0.868 rs6573007 chr14:55625938 T/G cg23234261 chr14:55582407 NA -0.29 -5.7 -0.3 2.71e-8 Protein biomarker; CRC cis rs2050392 0.792 rs9338188 chr10:30721963 G/C cg18806716 chr10:30721971 MAP3K8 -0.5 -7.49 -0.38 6.43e-13 Inflammatory bowel disease; CRC cis rs4499344 0.664 rs259284 chr19:33163262 T/C cg08127369 chr19:33164662 ANKRD27 0.39 6.01 0.31 5.05e-9 Mean platelet volume; CRC cis rs12477438 0.520 rs13022329 chr2:99731189 A/T cg26064155 chr2:99771622 LIPT1;TSGA10 0.88 16.22 0.67 6.67e-44 Chronic sinus infection; CRC cis rs3785574 0.582 rs62072238 chr17:61948841 A/T cg06601766 chr17:61851465 DDX42;CCDC47 0.55 7.85 0.4 5.8e-14 Height; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg23002658 chr20:52824474 PFDN4 0.46 6.59 0.34 1.73e-10 Response to antipsychotic treatment; CRC trans rs2303319 0.504 rs1006427 chr2:162592328 T/C cg18122310 chr12:50236657 BCDIN3D -0.73 -6.35 -0.33 7.23e-10 Cognitive function; CRC cis rs950169 0.922 rs62028133 chr15:84919375 A/C cg17507749 chr15:85114479 UBE2QP1 0.75 10.99 0.52 3.83e-24 Schizophrenia; CRC cis rs2050392 1.000 rs2489864 chr10:30693744 C/G cg18806716 chr10:30721971 MAP3K8 -0.46 -6.98 -0.36 1.64e-11 Inflammatory bowel disease; CRC cis rs6840360 0.593 rs10222925 chr4:152690215 A/G cg09659197 chr4:152720779 NA 0.4 8.44 0.42 1.05e-15 Intelligence (multi-trait analysis); CRC cis rs270601 0.710 rs4705852 chr5:131602807 A/G cg18301423 chr5:131593218 PDLIM4 0.44 8.18 0.41 6.25e-15 Acylcarnitine levels; CRC cis rs10540 0.686 rs12421266 chr11:537120 C/T cg21784768 chr11:537496 LRRC56 -0.72 -6.87 -0.35 3.26e-11 Body mass index; CRC cis rs1223397 0.938 rs17767967 chr6:13282067 C/T cg06879394 chr6:13274151 PHACTR1 0.53 6.28 0.33 1.06e-9 Blood pressure; CRC cis rs9322193 0.923 rs4870267 chr6:149992708 C/G cg05861140 chr6:150128134 PCMT1 -0.37 -5.96 -0.31 6.32e-9 Lung cancer; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg04128394 chr6:86351353 SYNCRIP 0.43 6.35 0.33 7.05e-10 Intelligence (multi-trait analysis); CRC cis rs17376456 0.877 rs10055741 chr5:93297187 C/T cg21475434 chr5:93447410 FAM172A 0.77 7.8 0.4 8.13e-14 Diabetic retinopathy; CRC cis rs1865760 1.000 rs9358895 chr6:25924655 C/T cg16482183 chr6:26056742 HIST1H1C 0.55 7.96 0.4 2.84e-14 Height; CRC cis rs9733 0.596 rs17606613 chr1:150683015 C/T cg17724175 chr1:150552817 MCL1 0.57 9.12 0.45 7.76e-18 Tonsillectomy; CRC cis rs4601821 0.789 rs7123797 chr11:113262571 A/G cg14159747 chr11:113255604 NA 0.52 10.24 0.49 1.58e-21 Alcoholic chronic pancreatitis; CRC cis rs11148252 0.840 rs56304200 chr13:52781763 T/A cg12458913 chr13:53173898 NA 0.54 8.48 0.42 7.8e-16 Lewy body disease; CRC cis rs8072100 0.738 rs9900123 chr17:45549055 T/C cg08085267 chr17:45401833 C17orf57 -0.56 -8.73 -0.43 1.29e-16 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs1552244 1.000 rs35741213 chr3:10087661 A/G cg18598329 chr3:10140678 FANCD2;C3orf24 -0.87 -11.82 -0.55 4.24e-27 Alzheimer's disease; CRC cis rs116095464 0.558 rs7703803 chr5:292311 A/G cg22496380 chr5:211416 CCDC127 -0.9 -10.1 -0.49 4.58e-21 Breast cancer; CRC cis rs9372498 0.536 rs62424198 chr6:118827247 A/G cg07617317 chr6:118971624 C6orf204 0.5 6.26 0.33 1.19e-9 Diastolic blood pressure; CRC cis rs7772486 0.790 rs6923545 chr6:146244743 A/G cg13319975 chr6:146136371 FBXO30 0.43 6.52 0.34 2.66e-10 Lobe attachment (rater-scored or self-reported); CRC cis rs3771570 1.000 rs73004354 chr2:242356239 G/T cg21155796 chr2:242212141 HDLBP 0.65 6.98 0.36 1.67e-11 Prostate cancer; CRC cis rs11758351 1.000 rs17598927 chr6:26184640 C/G cg22723502 chr6:26240528 HIST1H4F 0.41 6.33 0.33 8.16e-10 Gout;Renal underexcretion gout; CRC cis rs870825 0.932 rs10034861 chr4:185577450 C/T cg04058563 chr4:185651563 MLF1IP 0.73 7.31 0.37 2.02e-12 Blood protein levels; CRC cis rs2576037 0.901 rs6507719 chr18:44581310 A/T cg23996704 chr18:44553084 KATNAL2 0.3 5.89 0.31 9.68e-9 Personality dimensions; CRC cis rs1153858 1.000 rs12595087 chr15:45655232 A/G cg10760299 chr15:45669010 GATM 0.52 8.23 0.41 4.56e-15 Homoarginine levels; CRC cis rs9527 0.615 rs7917295 chr10:104701187 A/G cg04362960 chr10:104952993 NT5C2 0.59 8.34 0.42 2.04e-15 Arsenic metabolism; CRC cis rs5753618 0.583 rs7293171 chr22:31802324 T/C cg22777020 chr22:31556080 RNF185 0.54 6.35 0.33 7.06e-10 Colorectal cancer; CRC cis rs10876993 0.890 rs1092472 chr12:58036688 G/T cg18357645 chr12:58087776 OS9 0.53 7.19 0.37 4.35e-12 Celiac disease or Rheumatoid arthritis; CRC cis rs7937682 0.921 rs11213945 chr11:111461003 A/G cg09085632 chr11:111637200 PPP2R1B 1.0 15.95 0.66 8.1e-43 Primary sclerosing cholangitis; CRC cis rs9649213 0.593 rs3779193 chr7:98028466 T/C cg00277769 chr7:97922759 BAIAP2L1 -0.57 -9.69 -0.47 1.06e-19 Prostate cancer (SNP x SNP interaction); CRC cis rs1790761 1.000 rs1790761 chr11:67221854 T/C cg17375396 chr11:67202808 RPS6KB2 0.33 5.65 0.3 3.4e-8 Mean corpuscular volume; CRC cis rs9549328 0.527 rs9549622 chr13:113640064 A/C cg17524180 chr13:113633600 MCF2L -0.5 -6.23 -0.32 1.47e-9 Systolic blood pressure; CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg04915463 chr1:162039957 NOS1AP -0.52 -6.28 -0.33 1.05e-9 Diisocyanate-induced asthma; CRC cis rs7493 1.000 rs2286232 chr7:95039445 C/T cg07404485 chr7:94953653 PON1 -0.45 -6.04 -0.32 4.26e-9 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs12545109 0.836 rs2196586 chr8:57347126 C/T cg09654669 chr8:57350985 NA 0.43 6.29 0.33 1.04e-9 Obesity-related traits; CRC cis rs7131987 0.903 rs11050152 chr12:29404424 G/T cg09582351 chr12:29534625 ERGIC2 -0.33 -7.07 -0.36 9.16e-12 QT interval; CRC cis rs909002 0.789 rs2139539 chr1:32117779 C/T cg01639898 chr1:32083012 HCRTR1 0.33 7.03 0.36 1.23e-11 Intelligence (multi-trait analysis); CRC cis rs9837602 1.000 rs793496 chr3:99507254 T/C cg07805332 chr3:99536008 MIR548G;C3orf26 0.45 5.94 0.31 7.07e-9 Breast cancer; CRC cis rs11030122 0.673 rs11030639 chr11:4039056 A/G cg18678763 chr11:4115507 RRM1 -0.46 -7.76 -0.39 1.06e-13 Mean platelet volume;Platelet distribution width; CRC cis rs7089973 0.872 rs7074729 chr10:116632257 C/G cg23260525 chr10:116636907 FAM160B1 0.32 6.87 0.35 3.2e-11 Bipolar disorder or attention deficit hyperactivity disorder; CRC cis rs6964587 0.934 rs35968894 chr7:91762145 A/G cg17063962 chr7:91808500 NA 0.77 11.3 0.53 3.08e-25 Breast cancer; CRC cis rs10905065 0.648 rs4237365 chr10:5821484 T/G cg11519256 chr10:5708881 ASB13 -0.43 -6.16 -0.32 2.1e-9 Menopause (age at onset); CRC cis rs11764590 0.694 rs10276536 chr7:2086960 C/T cg24505167 chr7:1915268 MAD1L1 -0.34 -5.62 -0.3 4.08e-8 Neuroticism; CRC trans rs12887734 0.569 rs66953418 chr14:104271470 G/A cg06206626 chr22:26825900 ASPHD2 0.41 6.09 0.32 3.15e-9 Schizophrenia;Autism spectrum disorder or schizophrenia; CRC cis rs798554 0.797 rs798486 chr7:2803037 A/G cg17321639 chr7:2759063 NA -0.47 -6.2 -0.32 1.69e-9 Height; CRC cis rs765787 0.530 rs12913123 chr15:45516425 C/T cg24006582 chr15:45444508 DUOX1 0.57 8.28 0.42 3.18e-15 Uric acid levels; CRC cis rs79387448 0.626 rs80256362 chr2:103025501 A/G cg09003973 chr2:102972529 NA 0.82 8.42 0.42 1.21e-15 Gut microbiota (bacterial taxa); CRC cis rs1983891 0.909 rs4714482 chr6:41528199 G/A cg20194872 chr6:41519635 FOXP4 0.4 5.75 0.3 2.04e-8 Prostate cancer; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg21685266 chr3:184971652 EHHADH 0.41 6.0 0.31 5.22e-9 Response to antipsychotic treatment; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg19586645 chr17:73266642 MIF4GD 0.47 6.24 0.33 1.35e-9 Thyroid stimulating hormone; CRC trans rs2243480 1.000 rs73142162 chr7:65374296 A/T cg10756647 chr7:56101905 PSPH 0.71 7.42 0.38 1.03e-12 Diabetic kidney disease; CRC cis rs7843479 0.562 rs4872191 chr8:21824547 A/G cg17168535 chr8:21777572 XPO7 0.6 10.2 0.49 2.14e-21 Mean corpuscular volume; CRC cis rs883565 0.654 rs6779880 chr3:39022926 G/T cg01426195 chr3:39028469 NA 0.5 7.89 0.4 4.43e-14 Handedness; CRC cis rs7666738 0.830 rs35276471 chr4:99068691 A/T cg05340658 chr4:99064831 C4orf37 0.6 9.33 0.46 1.57e-18 Colonoscopy-negative controls vs population controls; CRC trans rs11039798 0.588 rs10838923 chr11:48534864 C/G cg03929089 chr4:120376271 NA 0.6 6.33 0.33 8.1e-10 Axial length; CRC cis rs3018066 0.640 rs7658701 chr4:107049150 C/T cg01869342 chr4:106983673 TBCK 0.47 6.11 0.32 2.83e-9 Cancer; CRC cis rs6694672 0.717 rs7539642 chr1:197063841 A/G cg13682187 chr1:196946512 CFHR5 0.47 7.57 0.39 3.82e-13 Asthma; CRC cis rs7113874 0.569 rs9737401 chr11:8595652 C/T cg02811074 chr11:8615871 STK33 -0.35 -6.02 -0.31 4.77e-9 Body mass index in physically active individuals;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs9372498 0.536 rs9489395 chr6:118758884 T/C cg18833306 chr6:118973337 C6orf204 0.44 5.74 0.3 2.12e-8 Diastolic blood pressure; CRC cis rs6496667 0.600 rs7174198 chr15:91083186 C/T cg04176472 chr15:90893244 GABARAPL3 0.5 7.39 0.38 1.2e-12 Rheumatoid arthritis; CRC cis rs614226 0.935 rs7956998 chr12:120994932 G/A cg27489772 chr12:121021490 NA 0.49 6.7 0.35 9.31e-11 Type 1 diabetes nephropathy; CRC cis rs8060686 0.544 rs1124993 chr16:68114626 T/C cg26727032 chr16:67993705 SLC12A4 -0.61 -8.22 -0.41 4.66e-15 HDL cholesterol;Metabolic syndrome; CRC cis rs7274811 0.901 rs17404047 chr20:32305781 A/T cg14921437 chr20:32255988 NECAB3;C20orf134 -0.47 -6.08 -0.32 3.4e-9 Height; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg03929741 chr13:107187681 EFNB2 0.35 6.08 0.32 3.25e-9 Liver disease severity in Alagille syndrome; CRC cis rs4478858 0.806 rs6686845 chr1:31708796 A/T cg00250761 chr1:31883323 NA -0.43 -8.54 -0.43 4.94e-16 Alcohol dependence; CRC cis rs116095464 0.558 rs10057674 chr5:266813 C/T cg22857025 chr5:266934 NA -1.26 -17.0 -0.68 5.78e-47 Breast cancer; CRC cis rs13108904 0.901 rs4974594 chr4:1300480 C/T cg15763984 chr4:1342303 KIAA1530 -0.35 -6.0 -0.31 5.34e-9 Obesity-related traits; CRC cis rs7811142 1.000 rs67040465 chr7:100083078 G/A cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.93 11.94 0.55 1.54e-27 Platelet count; CRC trans rs6600671 1.000 rs1986111 chr1:121204788 C/T cg09829573 chr1:144692074 NBPF9 -0.42 -6.2 -0.32 1.68e-9 Hip geometry; CRC cis rs826838 0.967 rs1352123 chr12:39130992 T/C cg13010199 chr12:38710504 ALG10B -0.41 -5.84 -0.31 1.27e-8 Heart rate; CRC cis rs9372498 0.536 rs55899435 chr6:118812099 C/T cg22561889 chr6:118971681 C6orf204 0.51 6.6 0.34 1.68e-10 Diastolic blood pressure; CRC cis rs769267 0.930 rs2288852 chr19:19605348 T/C cg01262667 chr19:19385393 TM6SF2 0.36 5.88 0.31 1.01e-8 Tonsillectomy; CRC cis rs28735056 1.000 rs28735056 chr18:77622879 A/G cg12845895 chr18:77676008 PQLC1 -0.39 -5.73 -0.3 2.3e-8 Schizophrenia; CRC cis rs1552244 0.882 rs13075842 chr3:10055813 A/C cg13047869 chr3:10149882 C3orf24 0.52 6.87 0.35 3.26e-11 Alzheimer's disease; CRC cis rs4588572 0.537 rs7705718 chr5:77730349 T/C cg11547950 chr5:77652471 NA -0.49 -7.08 -0.36 9e-12 Triglycerides; CRC cis rs7258465 1.000 rs7251653 chr19:18608283 C/T cg06462663 chr19:18546047 ISYNA1 0.48 7.26 0.37 2.73e-12 Breast cancer; CRC cis rs7772486 0.875 rs9390377 chr6:146386932 G/A cg23711669 chr6:146136114 FBXO30 0.69 12.05 0.55 6.09e-28 Lobe attachment (rater-scored or self-reported); CRC cis rs4731207 0.596 rs10252579 chr7:124637106 A/T cg23710748 chr7:124431027 NA -0.38 -6.17 -0.32 2.01e-9 Cutaneous malignant melanoma; CRC cis rs6582630 0.554 rs7299735 chr12:38450890 A/C cg26384229 chr12:38710491 ALG10B -0.54 -7.64 -0.39 2.47e-13 Drug-induced liver injury (flucloxacillin); CRC cis rs911555 0.755 rs2756132 chr14:103967820 C/G cg24130564 chr14:104152367 KLC1 0.43 5.75 0.3 2.04e-8 Intelligence (multi-trait analysis); CRC cis rs17331151 0.573 rs13080929 chr3:52885112 A/C cg06204229 chr3:52865917 ITIH4 0.55 7.59 0.39 3.41e-13 Immune reponse to smallpox (secreted IL-2); CRC trans rs2228479 0.702 rs11076621 chr16:89837927 A/G cg24644049 chr4:85504048 CDS1 0.9 7.57 0.39 3.72e-13 Skin colour saturation; CRC cis rs17756712 0.725 rs9504483 chr6:620222 C/T cg16786516 chr6:604617 EXOC2 0.48 6.27 0.33 1.1e-9 Vertical cup-disc ratio; CRC cis rs546131 0.928 rs552627 chr11:34826680 G/A cg24088639 chr11:34937564 PDHX;APIP -0.42 -5.87 -0.31 1.08e-8 Lung disease severity in cystic fibrosis; CRC cis rs2549003 1.000 rs6894655 chr5:131818649 T/C cg02551604 chr5:131831745 NA -0.54 -8.36 -0.42 1.76e-15 Asthma (sex interaction); CRC cis rs3018066 0.867 rs3133168 chr4:107252245 G/A cg01869342 chr4:106983673 TBCK 0.36 5.61 0.3 4.25e-8 Cancer; CRC cis rs908922 0.676 rs1053590 chr1:152488428 T/C cg23254163 chr1:152506842 NA 0.45 8.92 0.44 3.34e-17 Hair morphology; CRC cis rs7615952 0.641 rs12491577 chr3:125731131 C/T cg04553112 chr3:125709451 NA -0.51 -5.89 -0.31 9.72e-9 Blood pressure (smoking interaction); CRC trans rs1814175 0.562 rs1794130 chr11:49903764 T/A cg11707556 chr5:10655725 ANKRD33B -0.52 -9.95 -0.48 1.49e-20 Height; CRC cis rs10504229 0.953 rs6990806 chr8:58183113 G/A cg05313129 chr8:58192883 C8orf71 -0.47 -6.99 -0.36 1.49e-11 Developmental language disorder (linguistic errors); CRC trans rs11098499 0.863 rs7699064 chr4:120428309 A/G cg25214090 chr10:38739885 LOC399744 -0.65 -10.01 -0.48 9.21e-21 Corneal astigmatism; CRC cis rs7671266 0.611 rs10939833 chr4:10309537 A/G cg00071950 chr4:10020882 SLC2A9 -0.44 -6.09 -0.32 3.19e-9 Cardiovascular disease risk factors; CRC cis rs7804356 0.906 rs114978183 chr7:26852740 A/T cg03456212 chr7:26904342 SKAP2 -0.52 -5.68 -0.3 2.98e-8 Type 1 diabetes; CRC cis rs7959452 0.535 rs7133487 chr12:69774377 G/A cg14784868 chr12:69753453 YEATS4 0.83 14.29 0.62 2.24e-36 Blood protein levels; CRC cis rs6502050 0.835 rs3935816 chr17:80137173 C/T cg22110888 chr17:80059540 CCDC57 0.4 6.31 0.33 8.81e-10 Life satisfaction; CRC trans rs6601327 0.641 rs7462070 chr8:9571364 C/T cg06636001 chr8:8085503 FLJ10661 -0.52 -7.44 -0.38 8.97e-13 Multiple myeloma (hyperdiploidy); CRC cis rs2243480 1.000 rs4718333 chr7:65772758 T/C cg12463550 chr7:65579703 CRCP -0.69 -6.18 -0.32 1.85e-9 Diabetic kidney disease; CRC trans rs11225569 0.539 rs72987444 chr11:103314612 A/G cg01615333 chr12:127765195 NA -0.63 -5.97 -0.31 6.2e-9 Diisocyanate-induced asthma; CRC cis rs7726839 0.540 rs74553517 chr5:665671 C/T cg16447950 chr5:562315 NA -0.81 -10.49 -0.5 2.1e-22 Obesity-related traits; CRC trans rs35110281 0.782 rs4818856 chr21:45043495 A/G cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.51 8.51 0.42 6.09e-16 Mean corpuscular volume; CRC cis rs6121246 0.512 rs6060938 chr20:30363645 T/C cg13852791 chr20:30311386 BCL2L1 0.78 15.32 0.65 2.24e-40 Mean corpuscular hemoglobin; CRC trans rs7395662 0.591 rs4882085 chr11:48504569 C/G cg00717180 chr2:96193071 NA -0.36 -5.99 -0.31 5.51e-9 HDL cholesterol; CRC cis rs10540 1.000 rs61876341 chr11:495892 C/G cg21784768 chr11:537496 LRRC56 -0.68 -6.51 -0.34 2.8e-10 Body mass index; CRC cis rs3806843 0.735 rs2530242 chr5:140053351 G/C cg16607685 chr5:140181889 PCDHA2;PCDHA1;PCDHA3 0.26 5.9 0.31 8.88e-9 Depressive symptoms (multi-trait analysis); CRC cis rs13217239 0.646 rs10456352 chr6:26990358 A/T cg05192639 chr6:26864778 GUSBL1 0.31 6.01 0.31 5.05e-9 Schizophrenia; CRC cis rs6461049 0.519 rs3778992 chr7:2175313 C/G cg14004847 chr7:1930337 MAD1L1 -0.46 -7.1 -0.36 7.66e-12 Schizophrenia; CRC cis rs4862750 0.914 rs1991256 chr4:187875330 A/G cg10295955 chr4:187884368 NA -1.0 -23.15 -0.79 4.87e-71 Lobe attachment (rater-scored or self-reported); CRC cis rs853679 0.550 rs1150689 chr6:28165099 T/C cg15786705 chr6:28176104 NA 0.81 11.69 0.54 1.25e-26 Depression; CRC cis rs17433780 0.860 rs10922545 chr1:89492201 C/T cg09516651 chr1:89888402 LOC400759 0.48 7.29 0.37 2.38e-12 Carotid intima media thickness; CRC cis rs9648716 0.608 rs1267622 chr7:140528317 A/G cg17554604 chr7:140774522 NA 0.44 5.9 0.31 8.81e-9 Type 2 diabetes; CRC trans rs1814175 0.527 rs7128827 chr11:49665644 C/T cg18944383 chr4:111397179 ENPEP -0.48 -6.55 -0.34 2.19e-10 Height; CRC cis rs11098499 0.863 rs3775847 chr4:120447642 A/C cg24375607 chr4:120327624 NA 0.46 6.98 0.36 1.64e-11 Corneal astigmatism; CRC cis rs7772486 0.641 rs2748489 chr6:146331287 T/G cg05347473 chr6:146136440 FBXO30 0.46 6.51 0.34 2.84e-10 Lobe attachment (rater-scored or self-reported); CRC cis rs10504229 0.683 rs16921843 chr8:58113338 T/C cg04204079 chr8:58130323 NA -0.45 -5.84 -0.31 1.27e-8 Developmental language disorder (linguistic errors); CRC cis rs4974559 0.790 rs28712208 chr4:1316695 A/T cg02980000 chr4:1222292 CTBP1 0.47 5.95 0.31 7.05e-9 Systolic blood pressure; CRC cis rs1218582 0.741 rs2335407 chr1:154843347 A/G cg16680214 chr1:154839983 KCNN3 0.49 9.9 0.48 2.1e-20 Prostate cancer; CRC cis rs11212617 0.967 rs228608 chr11:108088900 C/T cg01991180 chr11:108092276 ATM;NPAT 0.43 6.32 0.33 8.58e-10 Response to metformin in type 2 diabetes (glycemic); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg19309549 chr1:100435460 SLC35A3 0.46 6.59 0.34 1.79e-10 Response to antipsychotic treatment; CRC cis rs877282 0.898 rs12359731 chr10:759497 A/G cg17470449 chr10:769945 NA 0.63 8.58 0.43 3.74e-16 Uric acid levels; CRC cis rs6582630 0.502 rs3902522 chr12:38271203 T/C cg26384229 chr12:38710491 ALG10B 0.66 9.19 0.45 4.44e-18 Drug-induced liver injury (flucloxacillin); CRC cis rs4900538 0.855 rs1210074 chr14:102889098 G/A cg18135206 chr14:102964638 TECPR2 -0.96 -16.68 -0.68 1.11e-45 Mean corpuscular volume;Mean corpuscular hemoglobin; CRC cis rs644799 0.965 rs502521 chr11:95533557 T/A cg25478527 chr11:95522999 CEP57;FAM76B 0.51 7.67 0.39 1.95e-13 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs3849570 0.925 rs2873054 chr3:81888255 A/C cg07356753 chr3:81810745 GBE1 -0.66 -9.74 -0.47 7.06e-20 Waist circumference;Body mass index; CRC cis rs9814567 0.762 rs13067564 chr3:134209956 A/G cg06109529 chr3:134205091 CEP63;ANAPC13 0.7 8.76 0.43 1.04e-16 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs847577 0.609 rs11765552 chr7:97822115 T/A cg21770322 chr7:97807741 LMTK2 0.86 19.38 0.73 2.28e-56 Breast cancer; CRC trans rs11148252 0.755 rs116860555 chr13:52936937 C/T cg18335740 chr13:41363409 SLC25A15 -0.53 -8.25 -0.41 3.83e-15 Lewy body disease; CRC cis rs1552244 0.935 rs11926481 chr3:10142102 G/T cg02579736 chr3:10068473 FANCD2;CIDECP 0.95 12.86 0.58 5.89e-31 Alzheimer's disease; CRC cis rs7666738 0.680 rs34267968 chr4:99002574 A/T cg17366294 chr4:99064904 C4orf37 0.44 7.39 0.38 1.19e-12 Colonoscopy-negative controls vs population controls; CRC cis rs7202877 0.656 rs9923834 chr16:75507253 T/A cg03315344 chr16:75512273 CHST6 0.52 6.17 0.32 1.97e-9 Type 2 diabetes;Type 1 diabetes; CRC cis rs9372498 0.505 rs4416700 chr6:118975461 G/C cg10217327 chr6:118973057 C6orf204 0.52 5.64 0.3 3.65e-8 Diastolic blood pressure; CRC cis rs4665809 0.590 rs1368902 chr2:26440576 T/C cg08067268 chr2:26466485 HADHB;HADHA -0.65 -8.34 -0.42 2e-15 Gut microbiome composition (summer); CRC cis rs58688157 0.705 rs36060383 chr11:598723 A/C cg11503833 chr11:492997 NA 0.44 5.66 0.3 3.31e-8 Systemic lupus erythematosus; CRC cis rs34172651 0.917 rs200533 chr16:24754771 C/T cg00339695 chr16:24857497 SLC5A11 -0.25 -6.01 -0.31 4.84e-9 Intelligence (multi-trait analysis); CRC cis rs9659323 0.612 rs10923721 chr1:119542187 A/G cg26570165 chr1:119541833 NA -0.43 -7.19 -0.37 4.49e-12 Body mass index; CRC trans rs10155879 0.505 rs12704265 chr7:86142678 A/G cg20049727 chr4:1981032 WHSC1 0.54 6.03 0.32 4.47e-9 Interleukin-4 levels; CRC cis rs2404602 0.669 rs12441484 chr15:77109875 G/A cg03037974 chr15:76606532 NA 0.67 11.41 0.53 1.28e-25 Blood metabolite levels; CRC trans rs2303319 0.504 rs56026147 chr2:162614089 T/C cg22922770 chr7:98923339 ARPC1A -0.67 -5.98 -0.31 5.68e-9 Cognitive function; CRC cis rs7932354 0.528 rs7946709 chr11:47100796 G/T cg03339077 chr11:47165057 C11orf49 0.43 6.11 0.32 2.74e-9 Bone mineral density (hip);Bone mineral density; CRC cis rs7927771 0.832 rs10769262 chr11:47411581 G/A cg20307385 chr11:47447363 PSMC3 0.65 9.47 0.46 5.59e-19 Subjective well-being; CRC cis rs6570726 0.846 rs6570700 chr6:145931552 A/G cg13319975 chr6:146136371 FBXO30 -0.44 -6.54 -0.34 2.33e-10 Lobe attachment (rater-scored or self-reported); CRC cis rs79387448 0.745 rs74560841 chr2:103149210 G/A cg09003973 chr2:102972529 NA 0.94 9.72 0.47 8.71e-20 Gut microbiota (bacterial taxa); CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg18473153 chr3:49726928 MST1;RNF123 0.44 6.06 0.32 3.83e-9 Anxiety disorder; CRC cis rs6933660 0.760 rs3806982 chr6:151774916 G/A cg14416726 chr6:151773293 C6orf211;RMND1 -0.64 -10.01 -0.48 9.08e-21 Menarche (age at onset); CRC cis rs6951245 1.000 rs76833820 chr7:1070278 A/T cg24642844 chr7:1081250 C7orf50 -0.78 -9.35 -0.46 1.42e-18 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs644799 0.710 rs523153 chr11:95570961 G/A cg25622487 chr11:95524042 FAM76B;CEP57 0.81 13.7 0.6 4.11e-34 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs2032447 0.933 rs4401650 chr6:26035208 G/A cg12310025 chr6:25882481 NA -0.52 -7.24 -0.37 3.1e-12 Intelligence (multi-trait analysis); CRC cis rs1448094 0.512 rs11832503 chr12:86240797 A/G cg19622623 chr12:86230825 RASSF9 -0.41 -6.73 -0.35 7.69e-11 Major depressive disorder; CRC cis rs1178968 0.901 rs757937 chr7:72750159 C/T cg25889504 chr7:72793014 NA 0.5 5.79 0.3 1.67e-8 Triglyceride levels; CRC cis rs826838 0.935 rs1601579 chr12:39178606 G/C cg26384229 chr12:38710491 ALG10B 0.69 9.46 0.46 6.22e-19 Heart rate; CRC cis rs13315871 0.929 rs71311852 chr3:58298843 G/A cg20936604 chr3:58311152 NA -0.74 -6.95 -0.36 1.93e-11 Cholesterol, total; CRC trans rs1455244 0.700 rs7229302 chr18:11508904 G/T cg04827747 chr7:134855666 C7orf49 0.4 6.03 0.32 4.41e-9 Schizophrenia; CRC cis rs9847710 0.733 rs11923593 chr3:53088790 A/G cg15147215 chr3:52552868 STAB1 0.42 5.67 0.3 3.15e-8 Ulcerative colitis; CRC cis rs847649 0.924 rs6960428 chr7:102589706 C/G cg18108683 chr7:102477205 FBXL13 0.57 9.33 0.46 1.65e-18 Morning vs. evening chronotype; CRC cis rs7666738 0.830 rs60994860 chr4:99046753 G/A cg05340658 chr4:99064831 C4orf37 0.6 9.35 0.46 1.4e-18 Colonoscopy-negative controls vs population controls; CRC cis rs9768139 0.708 rs11771764 chr7:158119871 A/G cg25566285 chr7:158114605 PTPRN2 0.46 7.18 0.37 4.55e-12 Calcium levels; CRC cis rs9911578 0.967 rs405684 chr17:56777148 T/C cg05425664 chr17:57184151 TRIM37 -0.5 -7.9 -0.4 4.34e-14 Intelligence (multi-trait analysis); CRC cis rs17739167 0.550 rs6493014 chr15:42225008 A/G cg20935245 chr15:42234343 EHD4 -0.42 -6.58 -0.34 1.82e-10 Monocyte count; CRC trans rs7618501 0.633 rs2624843 chr3:49997963 G/A cg21665057 chr3:196295764 WDR53;FBXO45 0.56 8.82 0.44 6.66e-17 Intelligence (multi-trait analysis); CRC cis rs758324 0.891 rs635164 chr5:131312874 C/T cg25547332 chr5:131281432 NA -0.39 -5.73 -0.3 2.27e-8 Alzheimer's disease in APOE e4- carriers; CRC cis rs9894429 1.000 rs3935543 chr17:79579874 T/C cg21984481 chr17:79567631 NPLOC4 -0.53 -9.8 -0.48 4.52e-20 Eye color traits; CRC cis rs6724607 1.000 rs7598979 chr2:191453375 A/G cg27211696 chr2:191398769 TMEM194B 0.39 5.8 0.3 1.59e-8 Pulse pressure; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg23224356 chr2:98206733 ANKRD36B 0.41 6.53 0.34 2.45e-10 Liver disease severity in Alagille syndrome; CRC cis rs9611565 0.765 rs767593 chr22:41779971 G/T cg06634786 chr22:41940651 POLR3H -0.69 -7.9 -0.4 4.34e-14 Vitiligo; CRC cis rs7762018 1.000 rs73242910 chr6:170114670 A/G cg24289452 chr6:170231220 NA -0.6 -6.59 -0.34 1.75e-10 Thiazide-induced adverse metabolic effects in hypertensive patients; CRC cis rs6502050 0.814 rs9894554 chr17:80073423 C/G cg13198984 chr17:80129470 CCDC57 -0.45 -7.83 -0.4 6.67e-14 Life satisfaction; CRC cis rs7833986 0.501 rs2953910 chr8:56968761 C/G cg23139584 chr8:56987506 RPS20;SNORD54 0.89 12.19 0.56 1.87e-28 Height; CRC trans rs1728785 1.000 rs1624718 chr16:68580385 A/G cg04657470 chr2:198365150 HSPE1;HSPD1 0.58 7.07 0.36 9.08e-12 Ulcerative colitis; CRC cis rs9549260 0.712 rs1334241 chr13:41223110 C/T cg21288729 chr13:41239152 FOXO1 0.49 6.17 0.32 2.02e-9 Red blood cell count; CRC cis rs62244186 0.545 rs7640654 chr3:44763037 A/C cg10263370 chr3:44754102 ZNF502 -0.38 -6.46 -0.34 3.84e-10 Depressive symptoms; CRC cis rs1005277 0.505 rs200935 chr10:38132810 T/A cg25427524 chr10:38739819 LOC399744 -0.72 -12.58 -0.57 6.62e-30 Extrinsic epigenetic age acceleration; CRC cis rs7833790 1.000 rs7460277 chr8:82709777 T/C cg27398817 chr8:82754497 SNX16 -0.55 -6.77 -0.35 6.06e-11 Diastolic blood pressure; CRC cis rs1401999 1.000 rs1402003 chr3:183642879 C/T cg05044414 chr3:183734942 ABCC5 0.47 8.18 0.41 6.18e-15 Anterior chamber depth; CRC cis rs1050631 0.564 rs12185396 chr18:33738496 C/T cg25426722 chr18:33708991 SLC39A6;ELP2 0.4 6.23 0.32 1.45e-9 Esophageal squamous cell cancer (length of survival); CRC cis rs4891159 0.756 rs8084155 chr18:74134952 A/G cg24786174 chr18:74118243 ZNF516 -0.88 -18.86 -0.72 2.61e-54 Longevity; CRC cis rs4727027 0.865 rs12154368 chr7:148862041 C/T cg23583168 chr7:148888333 NA -0.92 -16.26 -0.67 4.73e-44 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC cis rs3790844 0.876 rs3790845 chr1:200006861 C/T cg07208853 chr1:200005219 NR5A2 0.36 8.93 0.44 3.07e-17 Pancreatic cancer; CRC trans rs11098499 0.954 rs56270433 chr4:120406030 C/T cg25214090 chr10:38739885 LOC399744 0.64 10.33 0.49 7.46e-22 Corneal astigmatism; CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg11192808 chr8:101170185 SPAG1 0.42 6.89 0.36 2.9e-11 Obesity-related traits; CRC cis rs35110281 0.782 rs2329442 chr21:45041790 T/C cg04455712 chr21:45112962 RRP1B 0.41 8.02 0.4 1.88e-14 Mean corpuscular volume; CRC cis rs9300255 0.830 rs28413626 chr12:123861452 G/A cg02203224 chr12:123464087 ARL6IP4;OGFOD2 0.39 5.98 0.31 5.86e-9 Neutrophil percentage of white cells; CRC cis rs34779708 0.931 rs2490663 chr10:35329735 A/G cg03585969 chr10:35415529 CREM -0.57 -7.62 -0.39 2.72e-13 Inflammatory bowel disease;Crohn's disease; CRC cis rs4332037 0.552 rs11773627 chr7:2002733 A/G cg13880726 chr7:1868755 MAD1L1 -0.43 -5.71 -0.3 2.59e-8 Bipolar disorder; CRC cis rs7119 0.717 rs62007348 chr15:77804501 C/T cg10437265 chr15:77819839 NA 0.67 11.95 0.55 1.39e-27 Type 2 diabetes; CRC trans rs2243480 0.803 rs13224048 chr7:65993766 G/A cg10756647 chr7:56101905 PSPH 0.77 7.97 0.4 2.55e-14 Diabetic kidney disease; CRC cis rs7811142 1.000 rs11771241 chr7:99994785 G/A cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.62 7.89 0.4 4.53e-14 Platelet count; CRC cis rs9894429 0.572 rs112417725 chr17:79578219 A/G cg21028142 chr17:79581711 NPLOC4 -0.34 -7.12 -0.37 6.79e-12 Eye color traits; CRC cis rs4072980 0.545 rs10890285 chr1:38453576 A/C cg12658694 chr1:38397304 INPP5B -0.53 -7.26 -0.37 2.81e-12 Coronary artery disease; CRC cis rs699 0.556 rs2478520 chr1:230867197 G/A cg07502417 chr1:230849801 AGT 0.29 5.73 0.3 2.26e-8 Coronary artery disease; CRC cis rs728616 0.614 rs3934643 chr10:81736817 G/A cg05935833 chr10:81318306 SFTPA2 -0.48 -5.74 -0.3 2.18e-8 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs9372498 0.505 rs56406560 chr6:118991787 G/A cg10217327 chr6:118973057 C6orf204 0.47 5.6 0.3 4.45e-8 Diastolic blood pressure; CRC cis rs4604732 0.589 rs78689516 chr1:247626274 C/T cg12754571 chr1:247694271 LOC148824;OR2C3 0.41 5.75 0.3 2.04e-8 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CRC cis rs317689 0.513 rs317659 chr12:69686132 T/A cg20891283 chr12:69753455 YEATS4 0.7 11.16 0.52 9.5e-25 Response to diuretic therapy; CRC cis rs7605827 0.930 rs7606850 chr2:15678250 T/C cg19274914 chr2:15703543 NA 0.39 5.82 0.31 1.4e-8 Educational attainment (years of education); CRC cis rs875971 0.756 rs2901210 chr7:66017505 G/A cg18876405 chr7:65276391 NA -0.51 -8.32 -0.42 2.42e-15 Aortic root size; CRC cis rs4721295 0.573 rs3779000 chr7:2181628 G/A cg04267008 chr7:1944627 MAD1L1 -0.62 -8.4 -0.42 1.39e-15 Schizophrenia, schizoaffective disorder or bipolar disorder; CRC cis rs6693567 0.545 rs11205375 chr1:150412474 C/T cg15654264 chr1:150340011 RPRD2 0.42 6.19 0.32 1.76e-9 Migraine; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg10699215 chr4:10118516 WDR1 0.5 7.02 0.36 1.26e-11 Anxiety disorder; CRC cis rs10927875 0.793 rs1763619 chr1:16326935 A/G cg24140574 chr1:16342155 HSPB7 0.43 5.75 0.3 2.04e-8 Dilated cardiomyopathy; CRC cis rs7937682 1.000 rs2186839 chr11:111534442 T/G cg09085632 chr11:111637200 PPP2R1B -1.03 -21.02 -0.76 8.53e-63 Primary sclerosing cholangitis; CRC cis rs9487051 0.872 rs9386794 chr6:109611521 A/C cg01475377 chr6:109611718 NA -0.49 -9.33 -0.46 1.65e-18 Reticulocyte fraction of red cells; CRC cis rs7546094 0.935 rs6700673 chr1:113157054 C/T cg22162597 chr1:113214053 CAPZA1 0.44 6.03 0.32 4.39e-9 Platelet distribution width; CRC cis rs9487051 0.646 rs55677234 chr6:109621974 G/A cg01475377 chr6:109611718 NA -0.35 -5.66 -0.3 3.23e-8 Reticulocyte fraction of red cells; CRC cis rs2836974 0.666 rs12626405 chr21:40663121 G/T cg11644478 chr21:40555479 PSMG1 -0.68 -10.91 -0.52 7.58e-24 Cognitive function; CRC cis rs2880765 0.835 rs730372 chr15:86038193 G/T cg17133734 chr15:86042851 AKAP13 -0.43 -6.61 -0.34 1.56e-10 Coronary artery disease; CRC trans rs9858542 1.000 rs9822268 chr3:49719729 G/A cg21582582 chr3:182698605 DCUN1D1 -0.59 -7.14 -0.37 6.03e-12 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs16852403 0.583 rs10913506 chr1:178092233 G/A cg00404053 chr1:178313656 RASAL2 0.6 7.69 0.39 1.74e-13 Childhood ear infection; CRC cis rs2019137 0.936 rs3828188 chr2:113954247 G/A cg21550016 chr2:113992930 PAX8;LOC440839;LOC654433 -0.51 -7.29 -0.37 2.38e-12 Lymphocyte counts; CRC cis rs801193 1.000 rs10252765 chr7:66228732 C/G cg00343986 chr7:65444356 GUSB 0.48 7.0 0.36 1.42e-11 Aortic root size; CRC cis rs270601 0.690 rs162904 chr5:131595784 C/T cg20512303 chr5:131592959 PDLIM4 -0.39 -6.79 -0.35 5.16e-11 Acylcarnitine levels; CRC cis rs67311347 1.000 rs7628247 chr3:40512682 G/T cg24209194 chr3:40518798 ZNF619 -0.42 -6.03 -0.32 4.34e-9 Renal cell carcinoma; CRC cis rs7074356 0.688 rs7898568 chr10:82183531 G/A cg27171509 chr10:82033454 MAT1A -0.36 -6.5 -0.34 2.9e-10 Borderline personality disorder; CRC trans rs2303319 0.504 rs62189043 chr2:162608466 A/T cg11326919 chr17:43324904 LOC100133991 -0.64 -5.97 -0.31 5.99e-9 Cognitive function; CRC cis rs72781680 0.716 rs7564732 chr2:24034178 C/T cg08917208 chr2:24149416 ATAD2B 0.53 6.6 0.34 1.64e-10 Lymphocyte counts; CRC cis rs853679 0.760 rs11967137 chr6:28199764 A/G cg15786705 chr6:28176104 NA 0.65 6.92 0.36 2.38e-11 Depression; CRC cis rs10504229 1.000 rs17805549 chr8:58179653 T/C cg01721255 chr8:58191610 C8orf71 0.49 6.17 0.32 2e-9 Developmental language disorder (linguistic errors); CRC cis rs644799 0.672 rs11021347 chr11:95653494 T/C cg25478527 chr11:95522999 CEP57;FAM76B 0.44 6.56 0.34 2.11e-10 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs2346160 0.899 rs206972 chr6:167689552 C/T cg27333441 chr6:167680455 NA -0.34 -5.88 -0.31 1.02e-8 Parental extreme longevity (95 years and older); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg24269434 chr3:126076368 KLF15 0.42 6.78 0.35 5.58e-11 Liver disease severity in Alagille syndrome; CRC trans rs703108 0.731 rs7898954 chr10:22323646 A/G cg11637544 chr11:66886765 KDM2A -0.51 -6.12 -0.32 2.63e-9 Monocyte percentage of white cells; CRC cis rs2120019 0.938 rs8028632 chr15:75321262 T/C cg09165964 chr15:75287851 SCAMP5 -0.86 -13.39 -0.59 5.93e-33 Blood trace element (Zn levels); CRC cis rs4563143 0.675 rs56123392 chr19:29255631 A/C cg03161606 chr19:29218774 NA 0.52 6.52 0.34 2.68e-10 Methadone dose in opioid dependence; CRC cis rs9611565 0.512 rs5751145 chr22:42133552 C/T cg06634786 chr22:41940651 POLR3H 0.67 7.4 0.38 1.13e-12 Vitiligo; CRC cis rs72772090 0.710 rs11739280 chr5:96074147 C/T cg17330273 chr5:96107758 CAST;ERAP1 0.58 5.64 0.3 3.72e-8 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs59918340 0.728 rs10875467 chr8:142233396 A/C cg17298326 chr8:142245477 NA 0.39 6.06 0.32 3.79e-9 Immature fraction of reticulocytes; CRC cis rs1656402 0.861 rs1729255 chr2:233429196 C/G cg03852847 chr2:233439513 NA 0.41 6.79 0.35 5.34e-11 Non-small cell lung cancer (survival); CRC cis rs3736485 0.764 rs55805232 chr15:51896598 C/A cg08986416 chr15:51914746 DMXL2 -0.49 -6.88 -0.35 2.96e-11 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs6570726 0.875 rs416243 chr6:145868081 A/T cg05347473 chr6:146136440 FBXO30 0.38 6.1 0.32 3.02e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs9303542 0.694 rs4793854 chr17:46572133 A/G cg04904318 chr17:46607828 HOXB1 0.43 5.66 0.3 3.37e-8 Ovarian cancer;Epithelial ovarian cancer; CRC trans rs7395662 0.890 rs11039806 chr11:48547716 T/A cg21153622 chr11:89784906 NA -0.45 -7.18 -0.37 4.68e-12 HDL cholesterol; CRC cis rs2637266 0.514 rs11516642 chr10:78473522 G/T cg18941641 chr10:78392320 NA -0.33 -5.77 -0.3 1.87e-8 Pulmonary function; CRC cis rs1878931 0.559 rs1968055 chr16:3392053 A/G cg26668626 chr16:3451006 ZNF174;ZNF434 0.52 7.29 0.37 2.27e-12 Body mass index (adult); CRC cis rs910316 0.575 rs12889133 chr14:75465089 C/T cg08847533 chr14:75593920 NEK9 0.82 12.56 0.57 8.1e-30 Height; CRC cis rs67385638 1.000 rs2855121 chr11:5277291 C/T cg21506790 chr11:5277210 HBG2 0.36 5.84 0.31 1.27e-8 Hemoglobin levels; CRC cis rs853679 0.628 rs9368560 chr6:28159960 T/C cg12963246 chr6:28129442 ZNF389 0.46 5.66 0.3 3.32e-8 Depression; CRC cis rs10540 0.908 rs35608427 chr11:498976 T/C cg03576123 chr11:487126 PTDSS2 -1.03 -10.73 -0.51 3.17e-23 Body mass index; CRC cis rs34172651 0.517 rs11862923 chr16:24767303 G/T cg02428538 chr16:24856791 SLC5A11 -0.56 -6.66 -0.34 1.16e-10 Intelligence (multi-trait analysis); CRC cis rs875971 1.000 rs778699 chr7:65868290 G/A cg00343986 chr7:65444356 GUSB 0.43 6.3 0.33 9.66e-10 Aortic root size; CRC cis rs9649213 0.593 rs6945554 chr7:97972946 T/C cg00277769 chr7:97922759 BAIAP2L1 -0.6 -10.38 -0.5 5.03e-22 Prostate cancer (SNP x SNP interaction); CRC cis rs9992667 0.955 rs28510735 chr4:38613941 G/A cg19726192 chr4:38663646 FLJ13197 -0.59 -7.59 -0.39 3.27e-13 Eosinophil percentage of granulocytes; CRC trans rs1005277 0.602 rs1740743 chr10:38519222 C/T cg23533926 chr12:111358616 MYL2 -0.56 -8.67 -0.43 2e-16 Extrinsic epigenetic age acceleration; CRC cis rs4481887 0.741 rs7417519 chr1:248550370 C/T cg00666640 chr1:248458726 OR2T12 -0.41 -7.55 -0.38 4.34e-13 Common traits (Other); CRC cis rs11997175 0.646 rs61693382 chr8:33697255 A/C ch.8.33884649F chr8:33765107 NA 0.46 6.6 0.34 1.68e-10 Body mass index; CRC trans rs1814175 0.645 rs1851849 chr11:50012164 G/A cg11707556 chr5:10655725 ANKRD33B -0.52 -10.1 -0.49 4.49e-21 Height; CRC trans rs1814175 0.645 rs1851844 chr11:50021773 T/C cg11707556 chr5:10655725 ANKRD33B -0.52 -10.25 -0.49 1.36e-21 Height; CRC cis rs2153535 0.580 rs9328478 chr6:8519183 A/G cg07606381 chr6:8435919 SLC35B3 0.66 10.68 0.51 4.6e-23 Motion sickness; CRC cis rs13118159 0.550 rs10016557 chr4:1363628 C/T cg19318889 chr4:1322082 MAEA -0.71 -10.51 -0.5 1.77e-22 Longevity; CRC cis rs4144743 1.000 rs4144746 chr17:45323355 C/G cg18085866 chr17:45331354 ITGB3 -0.59 -8.11 -0.41 1.02e-14 Body mass index; CRC cis rs9308731 0.644 rs1821968 chr2:111880623 C/T cg04202892 chr2:111875749 ACOXL 0.47 7.64 0.39 2.32e-13 Chronic lymphocytic leukemia; CRC cis rs6743376 0.556 rs6733859 chr2:113819382 C/T cg09040174 chr2:113837401 NA 0.44 6.44 0.33 4.3e-10 Inflammatory biomarkers; CRC cis rs763121 0.853 rs6001173 chr22:39015302 A/G cg06544989 chr22:39130855 UNC84B 0.47 7.52 0.38 5.36e-13 Menopause (age at onset); CRC cis rs9916302 0.904 rs4357971 chr17:37717280 C/T cg00129232 chr17:37814104 STARD3 -0.56 -8.36 -0.42 1.83e-15 Glomerular filtration rate (creatinine); CRC cis rs9399137 0.507 rs11753673 chr6:135316476 T/C cg24558204 chr6:135376177 HBS1L 0.62 9.46 0.46 5.88e-19 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; CRC cis rs17376456 0.825 rs36042718 chr5:93180997 C/T cg21475434 chr5:93447410 FAM172A 0.75 7.34 0.37 1.73e-12 Diabetic retinopathy; CRC cis rs597539 0.652 rs478647 chr11:68700424 C/T cg21963583 chr11:68658836 MRPL21 0.58 10.35 0.5 6.51e-22 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs7826238 0.539 rs2945891 chr8:8155475 C/T cg06636001 chr8:8085503 FLJ10661 0.58 8.86 0.44 5.19e-17 Systolic blood pressure; CRC cis rs3858526 0.727 rs10769353 chr11:5954809 C/T cg25319279 chr11:5960081 NA 0.36 6.0 0.31 5.26e-9 DNA methylation (variation); CRC cis rs208520 0.690 rs1738970 chr6:66809491 T/G cg07460842 chr6:66804631 NA -1.09 -15.35 -0.65 1.82e-40 Exhaled nitric oxide output; CRC cis rs34172651 0.502 rs12930727 chr16:24838497 G/T cg06028605 chr16:24865363 SLC5A11 -0.39 -7.05 -0.36 1.05e-11 Intelligence (multi-trait analysis); CRC cis rs7412746 0.634 rs72704658 chr1:150833010 T/C cg15448220 chr1:150897856 SETDB1 0.55 7.71 0.39 1.55e-13 Melanoma; CRC trans rs11148252 0.514 rs1886539 chr13:52726090 C/T cg18335740 chr13:41363409 SLC25A15 0.48 7.05 0.36 1.07e-11 Lewy body disease; CRC cis rs2635047 1.000 rs2635049 chr18:44687303 C/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 -0.4 -6.69 -0.35 9.74e-11 Educational attainment; CRC cis rs924607 0.898 rs1697990 chr5:626278 A/G cg24163568 chr5:669837 TPPP -0.43 -6.87 -0.35 3.18e-11 Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia; CRC cis rs9311474 0.629 rs4282054 chr3:52566065 T/C cg11645453 chr3:52864694 ITIH4 0.34 6.28 0.33 1.04e-9 Electroencephalogram traits; CRC cis rs514406 0.861 rs4926577 chr1:53226788 C/A cg25767906 chr1:53392781 SCP2 0.45 7.12 0.37 6.95e-12 Monocyte count; CRC cis rs7680126 0.596 rs4698029 chr4:10312798 C/G cg11266682 chr4:10021025 SLC2A9 0.42 6.55 0.34 2.26e-10 Urate levels in lean individuals;Urate levels in overweight individuals;Urate levels in obese individuals; CRC cis rs365302 1.000 rs445227 chr6:159645888 A/G cg14500486 chr6:159655392 FNDC1 0.43 6.59 0.34 1.76e-10 Coronary heart disease; CRC cis rs2404602 0.684 rs1011084 chr15:77007480 C/G cg03037974 chr15:76606532 NA -0.48 -6.89 -0.36 2.8e-11 Blood metabolite levels; CRC cis rs4332037 0.722 rs28705934 chr7:1916116 T/A cg21155852 chr7:2048760 MAD1L1 -0.4 -5.62 -0.3 4.03e-8 Bipolar disorder; CRC cis rs951366 1.000 rs4951261 chr1:205717823 A/C cg07157834 chr1:205819609 PM20D1 -0.4 -5.73 -0.3 2.32e-8 Menarche (age at onset); CRC cis rs2731664 0.792 rs163199 chr5:176890067 A/G cg23176889 chr5:176863531 GRK6 -0.73 -15.87 -0.66 1.64e-42 Intelligence (multi-trait analysis); CRC trans rs561341 0.883 rs7219239 chr17:30212016 A/G cg20587970 chr11:113659929 NA 0.92 11.23 0.53 5.4e-25 Hip circumference adjusted for BMI; CRC cis rs13118159 0.550 rs1137789 chr4:1381798 A/G cg16405210 chr4:1374714 KIAA1530 -0.93 -15.18 -0.64 8.34e-40 Longevity; CRC cis rs60871478 0.636 rs7792072 chr7:886239 C/T cg05535760 chr7:792225 HEATR2 -0.9 -10.05 -0.48 6.51e-21 Cerebrospinal P-tau181p levels; CRC cis rs1862618 0.526 rs2591963 chr5:56237135 T/A cg03609598 chr5:56110824 MAP3K1 0.75 8.73 0.43 1.31e-16 Initial pursuit acceleration; CRC cis rs9322193 0.923 rs11155671 chr6:149972132 G/A cg05861140 chr6:150128134 PCMT1 -0.37 -5.88 -0.31 9.98e-9 Lung cancer; CRC cis rs1387259 0.929 rs2956703 chr12:48670294 C/T cg21466736 chr12:48725269 NA -0.55 -8.18 -0.41 6.36e-15 Obstructive sleep apnea trait (apnea hypopnea index); CRC cis rs10504229 1.000 rs17805326 chr8:58169533 A/C cg24829409 chr8:58192753 C8orf71 -0.68 -11.34 -0.53 2.17e-25 Developmental language disorder (linguistic errors); CRC cis rs10979 1.000 rs9496673 chr6:143885393 C/G cg25407410 chr6:143891975 LOC285740 -0.8 -13.03 -0.58 1.37e-31 Hypospadias; CRC cis rs2749592 0.550 rs10764135 chr10:37866845 C/T cg00409905 chr10:38381863 ZNF37A 0.59 9.38 0.46 1.08e-18 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs933688 1.000 rs889213 chr5:90682151 C/T cg26981201 chr5:90679533 LOC100129716;ARRDC3 1.02 15.59 0.65 1.97e-41 Smoking behavior; CRC cis rs35306767 1.000 rs35306767 chr10:989437 A/T cg20503657 chr10:835505 NA 1.02 12.14 0.56 2.72e-28 Eosinophil percentage of granulocytes; CRC cis rs909674 0.818 rs7364148 chr22:39842165 T/C cg24399712 chr22:39784796 NA -0.42 -8.01 -0.4 1.99e-14 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; CRC cis rs6748734 0.553 rs7340215 chr2:241805851 A/G cg16358738 chr2:241808595 AGXT -0.43 -7.32 -0.37 1.94e-12 Urinary metabolites; CRC trans rs7829975 0.564 rs2921060 chr8:8317817 G/T cg16141378 chr3:129829833 LOC729375 0.57 8.12 0.41 9.42e-15 Mood instability; CRC cis rs10782582 0.593 rs74090712 chr1:76189098 A/G cg10523679 chr1:76189770 ACADM -0.4 -5.81 -0.31 1.44e-8 Daytime sleep phenotypes; CRC cis rs514406 0.861 rs72637996 chr1:53249618 A/T cg27535305 chr1:53392650 SCP2 0.38 7.23 0.37 3.43e-12 Monocyte count; CRC cis rs1577917 0.665 rs4304137 chr6:86217448 G/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A 0.67 8.79 0.44 8.52e-17 Response to antipsychotic treatment; CRC cis rs2075371 0.501 rs1646653 chr7:134024686 A/G cg11752832 chr7:134001865 SLC35B4 0.43 6.35 0.33 7.31e-10 Mean platelet volume; CRC trans rs7726839 0.578 rs10080150 chr5:593160 C/T cg25482853 chr8:67687455 SGK3 -0.49 -6.7 -0.35 8.85e-11 Obesity-related traits; CRC cis rs9649213 0.593 rs3779193 chr7:98028466 T/C cg24562669 chr7:97807699 LMTK2 0.43 7.06 0.36 1.01e-11 Prostate cancer (SNP x SNP interaction); CRC cis rs9443645 0.810 rs9448607 chr6:79715620 G/A cg05283184 chr6:79620031 NA -0.55 -8.5 -0.42 6.61e-16 Intelligence (multi-trait analysis); CRC cis rs17095355 1.000 rs12570145 chr10:111712913 A/G cg00817464 chr10:111662876 XPNPEP1 -0.54 -6.4 -0.33 5.34e-10 Biliary atresia; CRC cis rs6502050 0.799 rs4132775 chr17:80155412 C/T cg25804541 chr17:80189381 SLC16A3 -0.29 -5.66 -0.3 3.38e-8 Life satisfaction; CRC cis rs9914988 0.943 rs28847895 chr17:27172520 T/C cg20469991 chr17:27169893 C17orf63 -0.48 -5.89 -0.31 9.66e-9 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC trans rs9858542 0.953 rs3811699 chr3:49396360 T/C cg21659725 chr3:3221576 CRBN -0.65 -8.96 -0.44 2.56e-17 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg20340149 chr2:122407145 CLASP1 0.46 7.5 0.38 5.94e-13 Liver disease severity in Alagille syndrome; CRC trans rs7859245 0.819 rs10117157 chr9:138490836 T/C cg14410503 chr7:47343076 TNS3 0.38 6.22 0.32 1.49e-9 Response to paliperidone in schizophrenia (negative Marder score); CRC cis rs6570726 0.791 rs11155433 chr6:145907831 A/G cg13319975 chr6:146136371 FBXO30 0.43 6.33 0.33 7.9e-10 Lobe attachment (rater-scored or self-reported); CRC cis rs501120 0.733 rs587375 chr10:44745808 T/C cg09554077 chr10:44749378 NA 0.9 13.3 0.59 1.4e-32 Coronary artery disease;Coronary heart disease; CRC cis rs6973256 0.865 rs4728295 chr7:133322680 A/T cg10665199 chr7:133106180 EXOC4 -0.38 -5.87 -0.31 1.04e-8 Intelligence (multi-trait analysis); CRC cis rs76878669 0.561 rs12416747 chr11:66135614 A/G cg18002602 chr11:66138449 SLC29A2 0.28 6.07 0.32 3.46e-9 Educational attainment (years of education); CRC cis rs6445525 0.875 rs7636595 chr3:65992843 A/T cg06109867 chr3:66002991 MAGI1 0.41 6.73 0.35 7.53e-11 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs2836974 0.863 rs6517519 chr21:40540245 A/G cg11644478 chr21:40555479 PSMG1 0.81 12.73 0.57 1.92e-30 Cognitive function; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg17969245 chr12:52463835 C12orf44 0.45 6.63 0.34 1.4e-10 Intelligence (multi-trait analysis); CRC cis rs6088580 0.634 rs6579165 chr20:32994715 A/G cg08999081 chr20:33150536 PIGU -0.61 -11.54 -0.54 4.11e-26 Glomerular filtration rate (creatinine); CRC cis rs1046896 0.731 rs9906115 chr17:80791469 G/A cg19046167 chr17:80928561 B3GNTL1 0.49 6.66 0.34 1.16e-10 Glycated hemoglobin levels; CRC cis rs6933660 0.512 rs13198669 chr6:151799924 A/G cg10883421 chr6:151773342 RMND1;C6orf211 -0.63 -7.07 -0.36 9.46e-12 Menarche (age at onset); CRC cis rs2795502 1.000 rs3121323 chr10:43377166 A/G cg20628663 chr10:43360327 NA -0.7 -11.03 -0.52 2.75e-24 Blood protein levels; CRC cis rs10503871 0.625 rs13250304 chr8:30346587 G/A cg26383811 chr8:30366931 RBPMS 0.49 7.88 0.4 4.89e-14 Metabolite levels (X-11787); CRC trans rs2243480 1.000 rs402418 chr7:65509469 G/A cg10756647 chr7:56101905 PSPH 0.75 7.66 0.39 2.05e-13 Diabetic kidney disease; CRC cis rs6424115 0.830 rs2502993 chr1:24201262 A/G cg15997130 chr1:24165203 NA 0.73 10.74 0.51 2.79e-23 Immature fraction of reticulocytes; CRC cis rs11758351 1.000 rs79868973 chr6:26189312 C/G cg22723502 chr6:26240528 HIST1H4F -0.37 -6.02 -0.31 4.76e-9 Gout;Renal underexcretion gout; CRC cis rs9611565 0.918 rs73176685 chr22:41781094 C/G cg06634786 chr22:41940651 POLR3H -0.6 -7.07 -0.36 9.39e-12 Vitiligo; CRC cis rs2404602 0.716 rs7179142 chr15:76698268 G/A cg22467129 chr15:76604101 ETFA -0.43 -7.23 -0.37 3.45e-12 Blood metabolite levels; CRC cis rs977987 0.806 rs1030262 chr16:75491327 C/A cg03315344 chr16:75512273 CHST6 0.56 9.53 0.46 3.73e-19 Dupuytren's disease; CRC cis rs6499255 0.904 rs9929720 chr16:69557096 C/T cg15192750 chr16:69999425 NA -0.5 -6.91 -0.36 2.46e-11 IgE levels; CRC cis rs9322193 0.962 rs4869731 chr6:150131208 T/C cg00933542 chr6:150070202 PCMT1 0.28 5.64 0.3 3.7e-8 Lung cancer; CRC trans rs2727020 0.658 rs10839278 chr11:49450847 G/C cg11707556 chr5:10655725 ANKRD33B -0.38 -7.24 -0.37 3.13e-12 Coronary artery disease; CRC cis rs60843830 1.000 rs62114505 chr2:242426 A/G cg00108164 chr2:264199 ACP1;SH3YL1 0.64 10.17 0.49 2.67e-21 Spherical equivalent (joint analysis main effects and education interaction); CRC cis rs2425143 1.000 rs2425142 chr20:34350346 G/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.48 -6.08 -0.32 3.36e-9 Blood protein levels; CRC cis rs10924970 1.000 rs2382567 chr1:235349803 A/G cg26050004 chr1:235667680 B3GALNT2 0.39 5.77 0.3 1.88e-8 Asthma; CRC cis rs4474465 0.850 rs10899539 chr11:78243743 T/C cg27205649 chr11:78285834 NARS2 0.51 6.66 0.34 1.15e-10 Alzheimer's disease (survival time); CRC cis rs4713118 0.513 rs149951 chr6:28033087 T/C cg12273811 chr6:28175739 NA 0.57 8.23 0.41 4.52e-15 Parkinson's disease; CRC cis rs12594515 1.000 rs6493172 chr15:45987213 T/G cg19682013 chr15:45996608 NA 0.32 6.7 0.35 9.18e-11 Waist circumference;Weight; CRC cis rs9902453 1.000 rs4074170 chr17:28381141 C/G cg26525008 chr17:28256777 EFCAB5;SSH2 -0.59 -8.79 -0.44 8.24e-17 Coffee consumption (cups per day); CRC cis rs17270561 0.666 rs4711099 chr6:25741809 C/G cg16482183 chr6:26056742 HIST1H1C 0.83 10.69 0.51 4.46e-23 Iron status biomarkers; CRC cis rs12692738 0.526 rs355854 chr2:165628693 T/C cg03182029 chr2:165697222 COBLL1 0.5 5.86 0.31 1.11e-8 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);Waist-to-hip ratio adjusted for BMI in non-smokers;Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction);Waist-to-hip ratio adjusted for body mass index; CRC cis rs13108904 0.518 rs4974603 chr4:1343168 C/T cg15763984 chr4:1342303 KIAA1530 0.49 7.94 0.4 3.26e-14 Obesity-related traits; CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg09351035 chr11:748060 TALDO1 -0.52 -6.19 -0.32 1.84e-9 Diisocyanate-induced asthma; CRC cis rs9309473 1.000 rs11903916 chr2:73815328 G/A cg20560298 chr2:73613845 ALMS1 -0.5 -6.19 -0.32 1.83e-9 Metabolite levels; CRC cis rs12479064 0.724 rs3792143 chr2:100057020 C/T cg14399236 chr2:99771627 LIPT1;TSGA10 -0.62 -7.35 -0.38 1.57e-12 Chronic sinus infection; CRC cis rs826838 0.616 rs2387921 chr12:38624767 T/C cg26384229 chr12:38710491 ALG10B -0.52 -7.52 -0.38 5.28e-13 Heart rate; CRC trans rs9409565 0.826 rs9409767 chr9:97228524 T/C cg05679027 chr9:99775184 HIATL2 -0.4 -6.13 -0.32 2.48e-9 Colorectal cancer (alcohol consumption interaction); CRC cis rs7095944 0.614 rs10901818 chr10:126449428 G/A cg08799069 chr10:126477246 METTL10 -0.44 -6.92 -0.36 2.41e-11 Asthma; CRC cis rs853679 0.517 rs4713152 chr6:28137454 G/A cg12172441 chr6:28176163 NA 0.64 7.53 0.38 5.03e-13 Depression; CRC cis rs72945132 0.882 rs72945194 chr11:70138621 A/G cg00319359 chr11:70116639 PPFIA1 0.64 6.36 0.33 6.89e-10 Coronary artery disease; CRC cis rs9640161 0.742 rs2108853 chr7:150017589 A/C cg12556325 chr7:150026731 C7orf29;LRRC61 -0.44 -6.46 -0.34 3.79e-10 Blood protein levels;Circulating chemerin levels; CRC cis rs875971 0.862 rs880166 chr7:65670762 T/C cg11764359 chr7:65958608 NA -0.61 -9.39 -0.46 1.06e-18 Aortic root size; CRC cis rs3008870 1.000 rs1118393 chr1:67366668 A/G cg08660285 chr1:67390436 MIER1;WDR78 1.03 15.97 0.66 6.69e-43 Lymphocyte percentage of white cells; CRC cis rs7914558 0.966 rs10786724 chr10:104668942 A/G cg15744005 chr10:104629667 AS3MT -0.34 -7.32 -0.37 1.97e-12 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs9291683 0.507 rs6849273 chr4:10021595 C/T cg00071950 chr4:10020882 SLC2A9 0.62 11.06 0.52 2.13e-24 Bone mineral density; CRC cis rs9311474 0.508 rs3796353 chr3:52593230 C/T cg18404041 chr3:52824283 ITIH1 -0.41 -8.71 -0.43 1.56e-16 Electroencephalogram traits; CRC trans rs11148252 0.538 rs3368 chr13:52707240 C/G cg18335740 chr13:41363409 SLC25A15 0.53 7.89 0.4 4.58e-14 Lewy body disease; CRC cis rs7017697 0.642 rs3927029 chr8:19681933 G/A cg03894339 chr8:19674705 INTS10 -0.46 -5.99 -0.31 5.6e-9 Breast cancer; CRC cis rs916888 0.773 rs538628 chr17:44787313 G/C cg01570182 chr17:44337453 NA 1.25 13.89 0.61 7.8e-35 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs28386778 0.897 rs2665833 chr17:61906846 T/C cg06873352 chr17:61820015 STRADA 0.77 14.48 0.62 4.35e-37 Prudent dietary pattern; CRC trans rs11764590 0.651 rs12673687 chr7:2081873 C/T cg11693508 chr17:37793320 STARD3 0.46 6.29 0.33 9.85e-10 Neuroticism; CRC cis rs17095355 1.000 rs1376111 chr10:111707255 C/T cg00817464 chr10:111662876 XPNPEP1 -0.6 -8.11 -0.41 1.04e-14 Biliary atresia; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg12564526 chr7:66767603 PMS2L4;STAG3L4 -0.43 -6.46 -0.34 3.85e-10 Myopia (pathological); CRC cis rs344364 0.636 rs344363 chr16:1972548 C/T cg09830162 chr16:1889614 FAHD1;C16orf73 -0.71 -8.03 -0.4 1.79e-14 Glomerular filtration rate in chronic kidney disease; CRC cis rs4692589 0.897 rs13145318 chr4:170991262 C/T cg19918862 chr4:170955249 NA -0.34 -5.66 -0.3 3.29e-8 Anxiety disorder; CRC cis rs7737355 0.947 rs6895841 chr5:130773534 A/G cg06307176 chr5:131281290 NA 0.42 6.15 0.32 2.3e-9 Life satisfaction; CRC cis rs881375 1.000 rs1609810 chr9:123642351 C/T cg09586646 chr9:123605570 PSMD5;LOC253039 0.5 6.82 0.35 4.46e-11 Rheumatoid arthritis; CRC cis rs11123170 0.543 rs35222158 chr2:113986629 C/T cg21482265 chr2:113992762 PAX8;LOC440839;LOC654433 0.51 6.05 0.32 3.84e-9 Renal function-related traits (BUN); CRC cis rs875971 1.000 rs1363055 chr7:65943275 A/G cg00343986 chr7:65444356 GUSB 0.43 6.29 0.33 1.03e-9 Aortic root size; CRC cis rs1008375 1.000 rs2159584 chr4:17620568 G/A cg16339924 chr4:17578868 LAP3 0.53 7.16 0.37 5.23e-12 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs2386661 0.826 rs7073741 chr10:5671213 G/A cg26603656 chr10:5671107 NA 0.55 9.19 0.45 4.6e-18 Breast cancer; CRC cis rs870825 0.616 rs7658186 chr4:185622509 T/C cg04058563 chr4:185651563 MLF1IP 0.72 9.36 0.46 1.32e-18 Blood protein levels; CRC cis rs10504229 0.683 rs7843919 chr8:58130792 T/C cg24829409 chr8:58192753 C8orf71 -0.55 -8.03 -0.4 1.71e-14 Developmental language disorder (linguistic errors); CRC cis rs8077889 0.917 rs9894873 chr17:41911832 A/G cg25876840 chr17:41920477 NA 0.54 7.77 0.39 1.02e-13 Triglycerides; CRC cis rs1552244 0.882 rs35056669 chr3:10014171 C/T cg00166722 chr3:10149974 C3orf24 0.61 7.96 0.4 2.85e-14 Alzheimer's disease; CRC cis rs6088580 0.634 rs6059850 chr20:33044784 C/G cg08999081 chr20:33150536 PIGU 0.6 11.2 0.53 6.8e-25 Glomerular filtration rate (creatinine); CRC trans rs3733585 0.699 rs2018643 chr4:9947121 C/T cg26043149 chr18:55253948 FECH 0.43 6.47 0.34 3.48e-10 Cleft plate (environmental tobacco smoke interaction); CRC cis rs3845702 0.877 rs12693216 chr2:180839793 T/A cg23417306 chr2:180868811 CWC22 -0.45 -6.09 -0.32 3.1e-9 Schizophrenia; CRC cis rs6831352 0.819 rs896992 chr4:100002372 C/T cg13256891 chr4:100009986 ADH5 0.47 6.4 0.33 5.47e-10 Alcohol dependence; CRC cis rs4478858 0.735 rs6670067 chr1:31842947 C/T cg00250761 chr1:31883323 NA -0.43 -8.2 -0.41 5.35e-15 Alcohol dependence; CRC cis rs9733 0.596 rs6678013 chr1:150623285 T/G cg18016565 chr1:150552671 MCL1 0.46 6.74 0.35 6.91e-11 Tonsillectomy; CRC cis rs4713118 0.629 rs172165 chr6:28020814 T/G cg12273811 chr6:28175739 NA 0.61 8.39 0.42 1.45e-15 Parkinson's disease; CRC trans rs1005277 0.563 rs2505216 chr10:38482830 T/C cg17830980 chr10:43048298 ZNF37B -0.6 -9.93 -0.48 1.76e-20 Extrinsic epigenetic age acceleration; CRC cis rs62007496 0.562 rs8176375 chr14:103605092 G/A cg09274347 chr14:103599552 TNFAIP2 0.51 5.77 0.3 1.81e-8 Language performance in older adults (adjusted for episodic memory); CRC cis rs17826219 0.706 rs9893922 chr17:29068425 T/C cg01831904 chr17:28903510 LRRC37B2 -0.63 -6.46 -0.34 3.66e-10 Body mass index; CRC trans rs208520 0.526 rs9294682 chr6:66795159 G/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.16 -25.23 -0.81 6.72e-79 Exhaled nitric oxide output; CRC cis rs13178541 0.551 rs4315919 chr5:135108794 G/A cg25640822 chr5:134871645 NEUROG1 -0.29 -5.77 -0.3 1.8e-8 IgG glycosylation; CRC cis rs6598955 0.671 rs11247904 chr1:26621804 G/A cg00852783 chr1:26633632 UBXN11 -0.49 -5.64 -0.3 3.6e-8 Obesity-related traits; CRC cis rs5769765 1.000 rs4824112 chr22:50284345 A/G cg02269571 chr22:50332266 NA -0.61 -8.23 -0.41 4.42e-15 Schizophrenia; CRC cis rs2991971 0.967 rs937291 chr1:45957039 G/T cg24296786 chr1:45957014 TESK2 0.56 8.44 0.42 1.05e-15 High light scatter reticulocyte count; CRC cis rs12594515 1.000 rs11070467 chr15:45985001 C/T cg06207120 chr15:45996521 NA -0.32 -7.58 -0.39 3.45e-13 Waist circumference;Weight; CRC cis rs9462846 0.658 rs9471970 chr6:42913646 G/A cg10862848 chr6:42927986 GNMT -0.29 -6.02 -0.32 4.54e-9 Blood protein levels; CRC cis rs10504229 0.953 rs72652908 chr8:58191324 G/A cg02725872 chr8:58115012 NA -0.38 -6.43 -0.33 4.44e-10 Developmental language disorder (linguistic errors); CRC cis rs4713118 0.662 rs9380045 chr6:28025279 A/G cg18032046 chr6:28092343 ZSCAN16 -0.51 -6.46 -0.34 3.86e-10 Parkinson's disease; CRC cis rs117623576 0.941 rs7098334 chr10:32418501 G/T cg03047570 chr10:32398778 NA -0.8 -8.92 -0.44 3.36e-17 Anti-saccade response; CRC cis rs7246657 0.943 rs1015849 chr19:37946180 G/A cg23950597 chr19:37808831 NA -0.54 -6.46 -0.34 3.68e-10 Coronary artery calcification; CRC cis rs9611565 0.802 rs9611571 chr22:41784867 G/A cg06481639 chr22:41940642 POLR3H -0.49 -5.76 -0.3 1.9e-8 Vitiligo; CRC cis rs9393692 1.000 rs3999544 chr6:26285867 C/T cg13736514 chr6:26305472 NA -0.66 -12.06 -0.55 5.38e-28 Educational attainment; CRC cis rs7726839 0.561 rs4957049 chr5:579080 C/A cg09021430 chr5:549028 NA -0.86 -10.87 -0.51 9.9e-24 Obesity-related traits; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg04968132 chr16:27560915 GTF3C1;KIAA0556 0.39 6.39 0.33 5.73e-10 Liver disease severity in Alagille syndrome; CRC cis rs6951245 0.572 rs79396168 chr7:1048928 C/T cg21664854 chr7:1097933 C7orf50;GPR146 0.74 5.73 0.3 2.26e-8 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC trans rs2797160 1.000 rs1418642 chr6:125999768 G/A cg05039488 chr6:79577232 IRAK1BP1 -0.5 -7.42 -0.38 1.01e-12 Endometrial cancer; CRC cis rs6908034 0.607 rs78402429 chr6:19811690 C/A cg02682789 chr6:19804855 NA 0.81 6.48 0.34 3.35e-10 Endometriosis;Deep ovarian and/or rectovaginal disease with dense adhesions; CRC cis rs2346177 0.519 rs1597040 chr2:46673903 C/T cg26688816 chr2:46740690 ATP6V1E2 -0.58 -8.91 -0.44 3.48e-17 HDL cholesterol; CRC cis rs4820294 1.000 rs78974622 chr22:38059925 A/C cg21798802 chr22:38057573 PDXP 0.47 7.41 0.38 1.04e-12 Fat distribution (HIV); CRC cis rs992157 0.798 rs10206064 chr2:219157959 T/C cg00012203 chr2:219082015 ARPC2 0.46 6.92 0.36 2.36e-11 Colorectal cancer; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg07730007 chr12:107377277 MTERFD3 -0.34 -5.98 -0.31 5.72e-9 Liver disease severity in Alagille syndrome; CRC cis rs9911578 0.757 rs4793954 chr17:56629527 G/T cg05425664 chr17:57184151 TRIM37 0.44 6.13 0.32 2.46e-9 Intelligence (multi-trait analysis); CRC cis rs6502050 0.799 rs6502066 chr17:80103737 T/C cg11859384 chr17:80120422 CCDC57 -0.37 -5.85 -0.31 1.16e-8 Life satisfaction; CRC cis rs4654899 0.795 rs61309203 chr1:21118489 A/T cg02927042 chr1:21476669 EIF4G3 -0.44 -6.87 -0.35 3.19e-11 Superior frontal gyrus grey matter volume; CRC cis rs2412459 1.000 rs8023482 chr15:40307095 A/C cg16127683 chr15:40268777 EIF2AK4 -0.78 -7.11 -0.37 7.18e-12 Response to haloperidol in psychosis; CRC trans rs4263408 0.934 rs9683743 chr4:39703194 A/C cg22171725 chr15:72523569 PKM2 -0.41 -6.05 -0.32 3.83e-9 Plasma amyloid beta peptide concentrations (ABx-40); CRC cis rs758324 0.947 rs600661 chr5:131290894 T/C cg25547332 chr5:131281432 NA -0.38 -5.61 -0.3 4.32e-8 Alzheimer's disease in APOE e4- carriers; CRC cis rs9443645 0.901 rs4706077 chr6:79548845 G/A cg11833968 chr6:79620685 NA -0.35 -6.06 -0.32 3.81e-9 Intelligence (multi-trait analysis); CRC cis rs1218582 0.774 rs4845683 chr1:154877407 T/C cg06221963 chr1:154839813 KCNN3 -0.8 -16.02 -0.66 4.21e-43 Prostate cancer; CRC cis rs8072100 0.840 rs56952963 chr17:45493826 T/C cg25173405 chr17:45401733 C17orf57 -0.48 -7.58 -0.39 3.52e-13 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs12188164 1.000 rs34847072 chr5:437862 G/C cg21972741 chr5:435613 AHRR 0.53 7.37 0.38 1.41e-12 Cystic fibrosis severity; CRC cis rs6743226 0.870 rs10933547 chr2:242230443 C/G cg10021735 chr2:242295487 FARP2 -0.46 -6.51 -0.34 2.75e-10 Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI in non-smokers; CRC cis rs7224737 1.000 rs8070446 chr17:40285879 G/A cg20291162 chr17:40259547 DHX58 -0.55 -7.98 -0.4 2.46e-14 Fibrinogen levels; CRC cis rs6502050 0.605 rs35158616 chr17:80094480 A/G cg09264619 chr17:80180166 NA -0.35 -5.77 -0.3 1.81e-8 Life satisfaction; CRC trans rs1656966 1.000 rs1656966 chr3:186466252 C/T cg17049621 chr17:42635778 FZD2 0.32 5.97 0.31 6.26e-9 Myopia (pathological); CRC trans rs10411161 0.702 rs8110073 chr19:52383123 C/A cg22319618 chr22:45562946 NUP50 -0.64 -7.09 -0.36 8.37e-12 Breast cancer; CRC cis rs58649573 0.552 rs2075064 chr9:126783847 C/T cg14112217 chr9:126806003 NA 0.4 5.8 0.3 1.55e-8 Post-traumatic stress disorder; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg25057861 chr10:72142518 LRRC20 0.42 6.34 0.33 7.59e-10 Intelligence (multi-trait analysis); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg27126666 chr15:93353059 NA 0.41 6.17 0.32 2.04e-9 Liver disease severity in Alagille syndrome; CRC cis rs7811142 0.830 rs78256546 chr7:99952970 A/G cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.11 15.98 0.66 5.9e-43 Platelet count; CRC cis rs3741404 0.895 rs2429455 chr11:63995302 C/G cg04317338 chr11:64019027 PLCB3 0.42 6.22 0.32 1.48e-9 Platelet count; CRC cis rs9814567 1.000 rs9876658 chr3:134179453 A/G cg06109529 chr3:134205091 CEP63;ANAPC13 0.75 11.23 0.53 5.48e-25 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs9908102 0.740 rs7211210 chr17:12917352 A/G cg26162695 chr17:12921313 ELAC2 0.43 5.66 0.3 3.27e-8 Schizophrenia; CRC cis rs6456156 0.792 rs4710179 chr6:167513692 G/T cg07513332 chr6:167530253 CCR6 0.38 6.25 0.33 1.27e-9 Primary biliary cholangitis; CRC cis rs902774 0.530 rs12819597 chr12:53353956 T/C cg25025879 chr12:53359317 NA -0.84 -7.91 -0.4 4e-14 Prostate cancer; CRC cis rs4332037 0.506 rs62442924 chr7:1989976 C/T cg23378565 chr7:2036160 MAD1L1 -0.41 -5.83 -0.31 1.34e-8 Bipolar disorder; CRC cis rs7412746 0.611 rs111842513 chr1:150712926 G/A cg17724175 chr1:150552817 MCL1 0.58 9.16 0.45 5.58e-18 Melanoma; CRC cis rs10504229 0.689 rs17801390 chr8:58054768 T/C cg08219700 chr8:58056026 NA 0.59 6.71 0.35 8.27e-11 Developmental language disorder (linguistic errors); CRC cis rs4839185 0.727 rs4838926 chr1:112463323 G/C cg27510354 chr1:112429786 KCND3 0.3 5.69 0.3 2.83e-8 P wave terminal force; CRC cis rs4319547 1.000 rs9705654 chr12:123083508 T/C cg05707623 chr12:122985044 ZCCHC8 -0.73 -9.2 -0.45 4.21e-18 Body mass index; CRC cis rs951366 0.646 rs1772159 chr1:205759195 G/A cg24503407 chr1:205819492 PM20D1 0.97 15.93 0.66 9.89e-43 Menarche (age at onset); CRC cis rs10540 1.000 rs61877760 chr11:506596 C/T cg08200582 chr11:442649 ANO9 -0.71 -7.42 -0.38 1.04e-12 Body mass index; CRC cis rs365302 1.000 rs422470 chr6:159649660 A/C cg14500486 chr6:159655392 FNDC1 0.44 6.82 0.35 4.31e-11 Coronary heart disease; CRC cis rs4713118 0.587 rs9393899 chr6:28133528 G/C cg23161317 chr6:28129485 ZNF389 0.53 6.43 0.33 4.52e-10 Parkinson's disease; CRC cis rs2832191 0.903 rs11700687 chr21:30486767 A/G cg08807101 chr21:30365312 RNF160 -0.62 -10.02 -0.48 8.3e-21 Dental caries; CRC trans rs72991 0.639 rs10790444 chr11:121235129 A/T cg27192990 chr6:129479024 LAMA2 0.42 6.14 0.32 2.34e-9 Response to tocilizumab in rheumatoid arthritis; CRC cis rs7666738 0.830 rs921523 chr4:98841659 C/T cg05340658 chr4:99064831 C4orf37 0.55 7.82 0.4 7.26e-14 Colonoscopy-negative controls vs population controls; CRC cis rs6456156 0.806 rs11967165 chr6:167529936 T/C cg07513332 chr6:167530253 CCR6 -0.47 -8.71 -0.43 1.46e-16 Primary biliary cholangitis; CRC cis rs2243480 0.901 rs778732 chr7:65822360 C/T cg12463550 chr7:65579703 CRCP 0.67 5.91 0.31 8.75e-9 Diabetic kidney disease; CRC cis rs7552404 0.727 rs7547508 chr1:76327958 A/G cg22875332 chr1:76189707 ACADM -0.53 -6.91 -0.36 2.5e-11 Blood metabolite levels;Acylcarnitine levels; CRC cis rs875971 0.830 rs778715 chr7:65849209 C/T cg00343986 chr7:65444356 GUSB 0.41 5.87 0.31 1.09e-8 Aortic root size; CRC cis rs1728785 0.901 rs12929568 chr16:68596689 A/G cg02972257 chr16:68554789 NA -0.48 -5.94 -0.31 7.44e-9 Ulcerative colitis; CRC cis rs10504229 0.815 rs72650879 chr8:58164648 A/G cg02725872 chr8:58115012 NA -0.59 -9.08 -0.45 1.02e-17 Developmental language disorder (linguistic errors); CRC trans rs7944735 0.517 rs11039538 chr11:48154990 A/T cg03929089 chr4:120376271 NA 0.65 6.03 0.32 4.45e-9 Intraocular pressure; CRC cis rs2197308 0.765 rs68029712 chr12:37906585 T/G cg26384229 chr12:38710491 ALG10B 0.67 8.82 0.44 6.9e-17 Morning vs. evening chronotype; CRC cis rs2952156 0.883 rs2517960 chr17:37846521 T/C cg20243544 chr17:37824526 PNMT 0.57 9.06 0.45 1.21e-17 Asthma; CRC cis rs4925325 0.955 rs1776262 chr20:60516023 G/T cg13770153 chr20:60521292 NA 0.93 17.01 0.68 5.24e-47 Obesity-related traits; CRC cis rs9443189 0.950 rs1280039 chr6:76514940 C/T cg01950844 chr6:76311363 SENP6 0.56 6.54 0.34 2.38e-10 Prostate cancer; CRC cis rs853679 0.567 rs13209596 chr6:28396190 C/A cg21251018 chr6:28226885 NKAPL 0.42 6.06 0.32 3.79e-9 Depression; CRC cis rs3784262 1.000 rs4646586 chr15:58305344 C/A cg12031962 chr15:58353849 ALDH1A2 -0.33 -5.86 -0.31 1.11e-8 Barrett's esophagus;Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined); CRC cis rs17127169 0.649 rs115401535 chr1:65484667 G/A cg01340542 chr1:65468273 NA 0.85 5.85 0.31 1.2e-8 Sitting height ratio; CRC cis rs4713675 0.584 rs4713667 chr6:33680016 G/C cg14003231 chr6:33640908 ITPR3 0.49 7.86 0.4 5.36e-14 Plateletcrit; CRC cis rs3617 0.625 rs7617468 chr3:52849549 T/C cg07507251 chr3:52567010 NT5DC2 0.4 6.07 0.32 3.55e-9 Red blood cell count;Autism spectrum disorder or schizophrenia; CRC cis rs4665809 0.590 rs10197494 chr2:26445550 A/G cg26119090 chr2:26468346 HADHA;HADHB -1.06 -15.5 -0.65 4.69e-41 Gut microbiome composition (summer); CRC cis rs7568458 0.663 rs699664 chr2:85780536 A/G cg02493740 chr2:85810744 VAMP5 0.57 9.52 0.46 3.94e-19 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); CRC cis rs801193 0.636 rs2659895 chr7:66196471 C/A cg11764359 chr7:65958608 NA 0.6 9.17 0.45 5.34e-18 Aortic root size; CRC cis rs11098499 1.000 rs3749591 chr4:120214030 T/G cg09307838 chr4:120376055 NA 0.65 9.81 0.48 4.38e-20 Corneal astigmatism; CRC cis rs2243480 1.000 rs781156 chr7:65479141 C/A cg18252515 chr7:66147081 NA -1.11 -12.71 -0.57 2.17e-30 Diabetic kidney disease; CRC cis rs116095464 0.558 rs7708515 chr5:234989 C/G cg22496380 chr5:211416 CCDC127 -0.87 -10.15 -0.49 3.1e-21 Breast cancer; CRC cis rs10504229 1.000 rs67039591 chr8:58174553 T/A cg24829409 chr8:58192753 C8orf71 -0.68 -11.34 -0.53 2.27e-25 Developmental language disorder (linguistic errors); CRC cis rs1799949 0.896 rs33933393 chr17:41317432 C/T cg05368731 chr17:41323189 NBR1 0.69 10.53 0.5 1.6e-22 Menopause (age at onset); CRC trans rs2727020 0.729 rs2866328 chr11:49282421 A/G cg21153622 chr11:89784906 NA 0.43 7.15 0.37 5.77e-12 Coronary artery disease; CRC cis rs514406 0.861 rs7417821 chr1:53295117 A/G cg24675658 chr1:53192096 ZYG11B -0.59 -9.2 -0.45 4.11e-18 Monocyte count; CRC cis rs6495122 0.501 rs12148488 chr15:75382542 G/T cg14664628 chr15:75095509 CSK 0.43 6.33 0.33 7.89e-10 Caffeine consumption;Diastolic blood pressure;Coffee consumption; CRC cis rs7809950 0.678 rs2237660 chr7:106862963 T/A cg23024343 chr7:107201750 COG5 -0.71 -9.35 -0.46 1.4e-18 Coronary artery disease; CRC cis rs13256369 1.000 rs13266699 chr8:8570313 A/T cg06671706 chr8:8559999 CLDN23 -0.63 -9.56 -0.47 2.86e-19 Obesity-related traits; CRC cis rs7618915 0.501 rs3774366 chr3:52641255 T/C cg05573699 chr3:52720067 GNL3;PBRM1 -0.47 -6.98 -0.36 1.62e-11 Bipolar disorder; CRC cis rs7772486 0.754 rs12199362 chr6:146118225 A/G cg05347473 chr6:146136440 FBXO30 0.39 5.88 0.31 1.02e-8 Lobe attachment (rater-scored or self-reported); CRC trans rs3960554 0.808 rs57721466 chr7:75710049 C/T cg19862616 chr7:65841803 NCRNA00174 0.75 8.64 0.43 2.45e-16 Eotaxin levels; CRC cis rs1799949 0.930 rs33968979 chr17:41297992 G/T cg05368731 chr17:41323189 NBR1 0.69 10.5 0.5 1.94e-22 Menopause (age at onset); CRC cis rs9372498 0.505 rs17080456 chr6:118985938 G/C cg15382696 chr6:118971807 C6orf204 0.6 7.45 0.38 8.42e-13 Diastolic blood pressure; CRC cis rs9826463 0.757 rs75100831 chr3:142244647 T/C cg20824294 chr3:142316082 PLS1 0.4 6.69 0.35 9.6e-11 QRS duration in Tripanosoma cruzi seropositivity; CRC cis rs1799949 0.930 rs8176194 chr17:41231221 A/C cg05368731 chr17:41323189 NBR1 0.67 9.72 0.47 8.48e-20 Menopause (age at onset); CRC cis rs9847710 1.000 rs12488768 chr3:53086234 C/T cg04503182 chr3:53078218 SFMBT1 -0.44 -7.16 -0.37 5.16e-12 Ulcerative colitis; CRC trans rs2303319 0.504 rs62189047 chr2:162613314 T/A cg22988483 chr14:93581567 ITPK1 -0.66 -6.07 -0.32 3.52e-9 Cognitive function; CRC cis rs9513593 1.000 rs16956449 chr13:99966605 A/G cg21788972 chr13:99853209 UBAC2 0.43 5.69 0.3 2.87e-8 Psoriasis; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg04977610 chr16:30366665 CD2BP2 0.39 6.38 0.33 6.18e-10 Liver disease severity in Alagille syndrome; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg26322434 chr3:61237156 FHIT 0.41 6.07 0.32 3.58e-9 Liver disease severity in Alagille syndrome; CRC cis rs72781680 0.559 rs72796103 chr2:23900382 G/A cg08917208 chr2:24149416 ATAD2B 1.02 9.16 0.45 5.8e-18 Lymphocyte counts; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg01153979 chr6:79577195 IRAK1BP1 0.39 6.05 0.32 3.86e-9 Liver disease severity in Alagille syndrome; CRC cis rs2179367 0.959 rs9373589 chr6:149707288 A/G cg11245181 chr6:149772854 ZC3H12D -0.4 -6.14 -0.32 2.36e-9 Dupuytren's disease; CRC cis rs2731664 0.792 rs335434 chr5:176867276 A/G cg23176889 chr5:176863531 GRK6 -0.7 -13.66 -0.6 5.86e-34 Intelligence (multi-trait analysis); CRC cis rs2836974 0.568 rs7282604 chr21:40536910 C/T cg17971929 chr21:40555470 PSMG1 -0.75 -11.7 -0.54 1.08e-26 Cognitive function; CRC cis rs7618501 0.521 rs2352984 chr3:49948728 T/C cg24308560 chr3:49941425 MST1R -0.45 -7.05 -0.36 1.06e-11 Intelligence (multi-trait analysis); CRC cis rs896854 0.812 rs2340586 chr8:95969261 G/A cg09323728 chr8:95962352 TP53INP1 -0.44 -7.34 -0.38 1.71e-12 Type 2 diabetes; CRC cis rs1401999 0.864 rs4148563 chr3:183725999 T/C cg01324343 chr3:183735012 ABCC5 0.78 13.88 0.61 8.63e-35 Anterior chamber depth; CRC cis rs4148883 0.675 rs116265877 chr4:100096896 G/A cg13256891 chr4:100009986 ADH5 0.42 6.09 0.32 3.07e-9 Alcohol dependence; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg13154104 chr2:10443632 HPCAL1 -0.42 -6.2 -0.32 1.72e-9 Liver disease severity in Alagille syndrome; CRC cis rs17711722 0.565 rs4275112 chr7:65198619 T/G cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.62 -9.58 -0.47 2.5e-19 Calcium levels; CRC cis rs1862618 0.853 rs6450408 chr5:56098146 T/C cg22800045 chr5:56110881 MAP3K1 0.57 6.26 0.33 1.23e-9 Initial pursuit acceleration; CRC cis rs2153535 0.580 rs2143357 chr6:8497196 A/G cg07606381 chr6:8435919 SLC35B3 0.66 10.62 0.51 7.62e-23 Motion sickness; CRC cis rs7666738 0.791 rs1896156 chr4:99020882 C/G cg05340658 chr4:99064831 C4orf37 0.61 9.51 0.46 4.05e-19 Colonoscopy-negative controls vs population controls; CRC trans rs1814175 0.541 rs12287397 chr11:49819799 G/A cg11707556 chr5:10655725 ANKRD33B -0.41 -7.7 -0.39 1.58e-13 Height; CRC cis rs1005277 0.579 rs2474571 chr10:38384639 T/G cg17219203 chr10:38645113 HSD17B7P2 -0.41 -5.77 -0.3 1.85e-8 Extrinsic epigenetic age acceleration; CRC cis rs9287719 0.967 rs759402 chr2:10729554 A/T cg00105475 chr2:10696890 NA 0.45 7.26 0.37 2.75e-12 Prostate cancer; CRC cis rs853679 0.517 rs9468292 chr6:28095355 G/A cg06470822 chr6:28175283 NA 1.0 13.33 0.59 1.06e-32 Depression; CRC cis rs72615157 0.539 rs72615159 chr7:99674286 G/A cg22004693 chr7:99632812 ZKSCAN1 0.41 6.42 0.33 4.7e-10 Lung function (FEV1/FVC); CRC cis rs629535 0.814 rs545720 chr8:70063370 T/C cg26132723 chr8:70041827 NA 0.35 5.78 0.3 1.69e-8 Dupuytren's disease; CRC cis rs9372498 0.536 rs62424175 chr6:118797381 T/A cg07617317 chr6:118971624 C6orf204 0.48 5.77 0.3 1.82e-8 Diastolic blood pressure; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg25016364 chr7:152457024 ACTR3B 0.46 6.58 0.34 1.9e-10 Response to antipsychotic treatment; CRC cis rs9611565 0.512 rs5758464 chr22:42171300 A/G cg06634786 chr22:41940651 POLR3H 0.65 6.63 0.34 1.41e-10 Vitiligo; CRC cis rs2019137 0.967 rs895412 chr2:113973964 T/C cg07772999 chr2:113993052 PAX8;LOC440839;LOC654433 -0.44 -6.24 -0.33 1.36e-9 Lymphocyte counts; CRC cis rs7811142 0.779 rs28680963 chr7:99905475 C/G cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.66 8.52 0.43 5.71e-16 Platelet count; CRC cis rs17253792 0.822 rs13379343 chr14:56050205 G/A cg24579896 chr14:56047964 C14orf33;KTN1 0.71 6.06 0.32 3.77e-9 Putamen volume; CRC cis rs10944 0.598 rs594686 chr5:78275768 T/C cg13121490 chr5:78280331 ARSB -0.46 -6.76 -0.35 6.33e-11 Blood and toenail selenium levels; CRC cis rs9796 0.727 rs61203391 chr15:41352912 C/G cg18705301 chr15:41695430 NDUFAF1 -0.38 -6.22 -0.32 1.49e-9 Menopause (age at onset); CRC cis rs853679 0.517 rs6922063 chr6:28094366 G/A cg06470822 chr6:28175283 NA 0.98 12.98 0.58 2.22e-31 Depression; CRC cis rs4692589 0.965 rs6842442 chr4:170933203 C/T cg19918862 chr4:170955249 NA 0.38 6.32 0.33 8.75e-10 Anxiety disorder; CRC cis rs7100689 0.784 rs3802637 chr10:82179699 G/C cg00277334 chr10:82204260 NA -0.45 -5.92 -0.31 7.95e-9 Post bronchodilator FEV1; CRC cis rs12188164 0.515 rs11744936 chr5:412112 C/T cg17553881 chr5:443987 EXOC3;C5orf55 -0.32 -6.53 -0.34 2.48e-10 Cystic fibrosis severity; CRC cis rs4713118 0.955 rs9468206 chr6:27690453 G/T cg03623178 chr6:28175578 NA 0.64 8.52 0.43 5.68e-16 Parkinson's disease; CRC cis rs7312933 0.703 rs12370778 chr12:42599696 T/A cg11827402 chr12:42719852 PPHLN1;ZCRB1 0.65 9.05 0.45 1.31e-17 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CRC cis rs3736485 0.868 rs8034197 chr15:51922506 C/G cg08986416 chr15:51914746 DMXL2 -0.47 -6.53 -0.34 2.55e-10 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs425277 0.606 rs262663 chr1:2084598 T/C cg04315214 chr1:2043799 PRKCZ -0.39 -6.81 -0.35 4.59e-11 Height; CRC cis rs10256972 0.621 rs2363285 chr7:1091644 C/T cg03923535 chr7:1197113 ZFAND2A 0.46 6.86 0.35 3.45e-11 Longevity;Endometriosis; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg06594919 chr10:102827590 NA 0.44 6.18 0.32 1.92e-9 Response to antipsychotic treatment; CRC cis rs11212617 1.000 rs227094 chr11:108233800 C/A cg12106634 chr11:108092400 ATM;NPAT 0.44 6.59 0.34 1.7e-10 Response to metformin in type 2 diabetes (glycemic); CRC cis rs7659604 0.689 rs4283687 chr4:122663460 A/G cg06713675 chr4:122721982 EXOSC9 -0.39 -5.87 -0.31 1.08e-8 Type 2 diabetes; CRC cis rs8060686 0.516 rs9939821 chr16:68167787 T/A cg26727032 chr16:67993705 SLC12A4 -0.58 -8.71 -0.43 1.52e-16 HDL cholesterol;Metabolic syndrome; CRC cis rs459193 1.000 rs157843 chr5:55799184 G/T cg18302225 chr5:55776401 NA 0.57 8.41 0.42 1.24e-15 Coronary artery disease;Type 2 diabetes;Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);Waist-to-hip ratio adjusted for BMI in non-smokers;Waist-to-hip ratio adjusted for BMI (smoking interaction);Waist-to-hip ratio adjusted for body mass index;Waist-hip ratio;Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction); CRC cis rs4975616 0.686 rs37011 chr5:1348798 A/T cg06550200 chr5:1325588 CLPTM1L -0.73 -11.68 -0.54 1.35e-26 Lung cancer; CRC cis rs10504229 0.636 rs77290284 chr8:58055269 G/T cg08219700 chr8:58056026 NA 0.53 6.08 0.32 3.31e-9 Developmental language disorder (linguistic errors); CRC cis rs6089584 0.888 rs2181590 chr20:60622843 T/C cg13770153 chr20:60521292 NA -0.58 -8.72 -0.43 1.38e-16 Body mass index; CRC cis rs56283067 0.847 rs62435998 chr6:44695206 C/T cg18551225 chr6:44695536 NA -0.4 -5.75 -0.3 2.02e-8 Total body bone mineral density; CRC cis rs7617773 1.000 rs6442109 chr3:48192981 G/A cg11946769 chr3:48343235 NME6 -0.5 -6.79 -0.35 5.37e-11 Coronary artery disease; CRC cis rs9359856 0.510 rs78649003 chr6:90454644 A/C cg13799429 chr6:90582589 CASP8AP2 -0.77 -10.0 -0.48 1.01e-20 Bipolar disorder; CRC cis rs9467711 0.606 rs34104395 chr6:26478252 C/T cg16898833 chr6:26189333 HIST1H4D 1.16 8.45 0.42 9.44e-16 Autism spectrum disorder or schizophrenia; CRC cis rs6448317 0.954 rs35276311 chr4:24923493 C/T cg21108841 chr4:24914750 CCDC149 -0.46 -6.07 -0.32 3.58e-9 Heschl's gyrus morphology; CRC cis rs265548 0.608 rs36690 chr19:17910483 C/T cg16744531 chr19:17905626 B3GNT3 0.6 9.99 0.48 1.05e-20 Tumor biomarkers; CRC cis rs4665809 0.590 rs4665319 chr2:26424583 A/C cg22920501 chr2:26401640 FAM59B -0.69 -9.96 -0.48 1.34e-20 Gut microbiome composition (summer); CRC cis rs2932538 0.614 rs6537741 chr1:113085175 A/C cg22162597 chr1:113214053 CAPZA1 -0.6 -7.13 -0.37 6.55e-12 Systolic blood pressure;Diastolic blood pressure;Hypertension;Blood pressure; CRC trans rs7395662 0.591 rs11039858 chr11:48611651 C/T cg15704280 chr7:45808275 SEPT13 -0.47 -6.45 -0.34 4e-10 HDL cholesterol; CRC cis rs4481887 0.676 rs946761 chr1:248521032 T/C cg00666640 chr1:248458726 OR2T12 0.35 6.45 0.33 4.08e-10 Common traits (Other); CRC cis rs1799949 1.000 rs12950607 chr17:41299928 G/C cg01879757 chr17:41196368 BRCA1 -0.44 -6.67 -0.35 1.06e-10 Menopause (age at onset); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg03698729 chr19:2328812 SPPL2B;LSM7 0.42 6.57 0.34 2.01e-10 Liver disease severity in Alagille syndrome; CRC cis rs4713118 0.587 rs61471148 chr6:28037032 T/A cg23161317 chr6:28129485 ZNF389 0.51 6.47 0.34 3.63e-10 Parkinson's disease; CRC cis rs897984 0.684 rs6950 chr16:30995669 T/C cg00531865 chr16:30841666 NA 0.48 6.9 0.36 2.62e-11 Dementia with Lewy bodies; CRC cis rs4285028 0.848 rs4118376 chr3:121636450 G/A cg20356878 chr3:121714668 ILDR1 -0.48 -6.57 -0.34 1.99e-10 Multiple sclerosis; CRC cis rs597539 0.652 rs674654 chr11:68698762 G/T cg06112835 chr11:68658793 MRPL21 0.44 6.94 0.36 2.11e-11 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs270601 0.721 rs270621 chr5:131605821 C/A cg09877947 chr5:131593287 PDLIM4 0.55 9.48 0.46 5.32e-19 Acylcarnitine levels; CRC cis rs4285028 0.747 rs1128163 chr3:121350573 A/G cg20356878 chr3:121714668 ILDR1 -0.41 -5.77 -0.3 1.84e-8 Multiple sclerosis; CRC cis rs11155671 0.530 rs7742993 chr6:150205095 G/A cg13206674 chr6:150067644 NUP43 0.49 7.02 0.36 1.27e-11 Testicular germ cell tumor; CRC cis rs11190604 1.000 rs6584379 chr10:102224490 G/A cg16342193 chr10:102329863 NA -0.37 -6.1 -0.32 2.96e-9 Palmitoleic acid (16:1n-7) levels; CRC cis rs4920343 0.645 rs851115 chr1:19070229 T/A cg26220594 chr1:19110978 NA 0.36 5.67 0.3 3.09e-8 Knee osteoarthritis; CRC cis rs9487051 0.698 rs9400276 chr6:109647405 C/T cg01475377 chr6:109611718 NA -0.37 -5.76 -0.3 1.91e-8 Reticulocyte fraction of red cells; CRC cis rs10504229 0.683 rs7835498 chr8:58129780 A/C cg02725872 chr8:58115012 NA -0.64 -11.55 -0.54 3.85e-26 Developmental language disorder (linguistic errors); CRC cis rs4332037 0.539 rs1533827 chr7:2074290 A/G cg23378565 chr7:2036160 MAD1L1 0.44 6.46 0.34 3.82e-10 Bipolar disorder; CRC cis rs3741404 0.825 rs11603384 chr11:63949095 G/A cg05016508 chr11:63871570 FLRT1;MACROD1 0.47 7.02 0.36 1.25e-11 Platelet count; CRC cis rs9388451 0.839 rs3799709 chr6:126078361 A/G cg05901451 chr6:126070800 HEY2 -0.68 -11.85 -0.55 3.29e-27 Brugada syndrome; CRC cis rs736408 0.608 rs6445534 chr3:52743384 G/A cg18404041 chr3:52824283 ITIH1 -0.4 -8.29 -0.42 3.02e-15 Bipolar disorder; CRC cis rs10450586 0.932 rs10767628 chr11:27310871 C/G cg10370305 chr11:27303972 NA 0.37 6.04 0.32 4.19e-9 Total body bone mineral density; CRC cis rs12681287 0.640 rs13253261 chr8:87458500 T/C cg27223183 chr8:87520930 FAM82B -0.52 -7.44 -0.38 8.7e-13 Caudate activity during reward; CRC cis rs13256369 1.000 rs873064 chr8:8572380 G/A cg18904891 chr8:8559673 CLDN23 0.48 6.4 0.33 5.48e-10 Obesity-related traits; CRC trans rs2303319 0.504 rs62189042 chr2:162602320 G/T cg09481857 chr22:21368659 P2RX6;MGC16703 -0.65 -6.31 -0.33 9.13e-10 Cognitive function; CRC cis rs748404 0.690 rs2467737 chr15:43737188 G/A cg02155558 chr15:43621948 ADAL;LCMT2 0.52 7.63 0.39 2.49e-13 Lung cancer; CRC cis rs7680126 0.596 rs12511337 chr4:10311972 A/G cg00071950 chr4:10020882 SLC2A9 0.46 5.98 0.31 5.71e-9 Urate levels in lean individuals;Urate levels in overweight individuals;Urate levels in obese individuals; CRC cis rs7412746 0.658 rs3768016 chr1:150809919 T/C cg17724175 chr1:150552817 MCL1 0.48 7.16 0.37 5.35e-12 Melanoma; CRC cis rs2180341 0.640 rs11154395 chr6:127629138 T/C cg27446573 chr6:127587934 RNF146 0.63 9.28 0.46 2.39e-18 Breast cancer; CRC cis rs7590720 1.000 rs6435930 chr2:216885852 A/G cg12620499 chr2:216877984 MREG 0.87 14.43 0.62 6.32e-37 Alcohol dependence; CRC trans rs783540 0.934 rs7182403 chr15:83297613 C/T cg18393722 chr15:85113863 UBE2QP1 -0.39 -6.92 -0.36 2.35e-11 Schizophrenia; CRC cis rs2625529 0.556 rs35603965 chr15:72523043 C/T cg16672083 chr15:72433130 SENP8 0.45 6.74 0.35 6.97e-11 Red blood cell count; CRC cis rs28386778 0.897 rs2584608 chr17:61936710 A/G cg06873352 chr17:61820015 STRADA 0.76 14.18 0.62 5.77e-36 Prudent dietary pattern; CRC cis rs10876993 0.928 rs1678530 chr12:58054076 A/C cg15848620 chr12:58087721 OS9 -0.65 -8.94 -0.44 2.88e-17 Celiac disease or Rheumatoid arthritis; CRC cis rs898097 0.690 rs12452304 chr17:80811659 G/A cg03160526 chr17:80928410 B3GNTL1 -0.41 -6.11 -0.32 2.76e-9 Breast cancer; CRC trans rs8073060 0.586 rs225300 chr17:33922428 C/T cg19694781 chr19:47549865 TMEM160 -1.01 -13.92 -0.61 5.81e-35 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; CRC cis rs9311676 0.609 rs11925862 chr3:58417927 A/C cg06643156 chr3:58380774 PXK 0.42 6.43 0.33 4.39e-10 Systemic lupus erythematosus; CRC cis rs910316 1.000 rs7147118 chr14:75610170 G/C cg08847533 chr14:75593920 NEK9 0.94 18.34 0.71 3e-52 Height; CRC cis rs873946 0.586 rs12783078 chr10:134569706 C/T cg06453172 chr10:134556979 INPP5A -0.69 -8.26 -0.41 3.5e-15 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CRC cis rs853679 0.517 rs2275508 chr6:28094731 T/C cg23161317 chr6:28129485 ZNF389 0.53 6.64 0.34 1.29e-10 Depression; CRC cis rs35264875 0.851 rs72930611 chr11:68863659 G/T cg15234197 chr11:68924956 NA 0.42 5.86 0.31 1.15e-8 Blond vs. brown hair color; CRC trans rs4902562 0.838 rs6573823 chr14:68733632 A/G cg20049727 chr4:1981032 WHSC1 0.48 6.38 0.33 5.89e-10 Systemic lupus erythematosus; CRC cis rs282587 0.502 rs282603 chr13:113393984 G/A cg04656015 chr13:113407548 ATP11A 0.55 7.19 0.37 4.27e-12 Glycated hemoglobin levels; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg12045676 chr19:18794818 CRTC1 0.47 7.15 0.37 5.73e-12 Intelligence (multi-trait analysis); CRC cis rs4654899 0.833 rs12135548 chr1:21084367 G/A cg02927042 chr1:21476669 EIF4G3 -0.43 -6.65 -0.34 1.21e-10 Superior frontal gyrus grey matter volume; CRC cis rs2304069 0.954 rs10068537 chr5:149403193 G/A cg22760475 chr5:149380129 HMGXB3;TIGD6 0.9 10.24 0.49 1.48e-21 HIV-1 control; CRC cis rs10504229 0.953 rs114853497 chr8:58176176 A/T cg02725872 chr8:58115012 NA -0.38 -6.43 -0.33 4.44e-10 Developmental language disorder (linguistic errors); CRC cis rs9487051 0.872 rs1111864 chr6:109611138 A/G cg12927641 chr6:109611667 NA -0.37 -6.73 -0.35 7.39e-11 Reticulocyte fraction of red cells; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg12182497 chr8:42128690 IKBKB 0.44 6.29 0.33 1.01e-9 Response to antipsychotic treatment; CRC trans rs2898290 0.622 rs4840567 chr8:11347625 A/G cg16141378 chr3:129829833 LOC729375 0.46 7.09 0.36 8.19e-12 Systolic blood pressure; CRC cis rs17711722 0.701 rs55773927 chr7:65337902 T/C cg02869306 chr7:64672164 INTS4L1 -0.35 -5.86 -0.31 1.1e-8 Calcium levels; CRC cis rs28735056 0.592 rs2277725 chr18:77694168 A/C cg20368463 chr18:77673604 PQLC1 -0.67 -11.1 -0.52 1.57e-24 Schizophrenia; CRC cis rs2281845 0.507 rs11589642 chr1:201100748 A/G cg22815214 chr1:201083145 CACNA1S -0.51 -6.44 -0.33 4.15e-10 Permanent tooth development; CRC cis rs1476679 0.927 rs2405442 chr7:99971313 T/C cg13334819 chr7:99746414 C7orf59 0.43 5.7 0.3 2.64e-8 Alzheimer's disease (late onset); CRC cis rs853679 0.550 rs1150692 chr6:28173957 A/G cg15786705 chr6:28176104 NA 0.78 11.0 0.52 3.62e-24 Depression; CRC cis rs10540 1.000 rs12794284 chr11:477623 C/T cg03934478 chr11:495069 RNH1 0.67 7.54 0.38 4.66e-13 Body mass index; CRC trans rs561341 1.000 rs72825740 chr17:30338356 A/G cg27661571 chr11:113659931 NA -0.96 -11.16 -0.52 9.58e-25 Hip circumference adjusted for BMI; CRC cis rs7666738 0.791 rs1593571 chr4:98963763 T/C cg17366294 chr4:99064904 C4orf37 0.43 7.36 0.38 1.49e-12 Colonoscopy-negative controls vs population controls; CRC cis rs754466 0.580 rs12356063 chr10:79558131 G/C cg17075019 chr10:79541650 NA -0.98 -19.57 -0.73 4.02e-57 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs4665809 0.941 rs7602922 chr2:26265782 C/T cg22920501 chr2:26401640 FAM59B -0.55 -7.2 -0.37 4.16e-12 Gut microbiome composition (summer); CRC cis rs2404602 0.647 rs12910081 chr15:77022959 G/C cg03037974 chr15:76606532 NA -0.54 -8.2 -0.41 5.41e-15 Blood metabolite levels; CRC cis rs8180040 0.932 rs1038394 chr3:47464122 A/G cg10298567 chr3:47292165 KIF9 -0.35 -5.75 -0.3 2.04e-8 Colorectal cancer; CRC cis rs9287719 0.967 rs6761678 chr2:10746341 T/C cg00105475 chr2:10696890 NA 0.45 7.15 0.37 5.48e-12 Prostate cancer; CRC cis rs7772486 0.840 rs2777478 chr6:146309117 T/C cg23711669 chr6:146136114 FBXO30 0.69 11.68 0.54 1.28e-26 Lobe attachment (rater-scored or self-reported); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg19151263 chr18:48724096 MEX3C 0.4 6.02 0.31 4.71e-9 Intelligence (multi-trait analysis); CRC cis rs7927592 0.871 rs12360903 chr11:68236314 C/A cg01657329 chr11:68192670 LRP5 -0.45 -6.32 -0.33 8.46e-10 Total body bone mineral density; CRC cis rs2075371 0.966 rs2544214 chr7:133985736 G/A cg11752832 chr7:134001865 SLC35B4 0.5 7.71 0.39 1.54e-13 Mean platelet volume; CRC cis rs2072510 0.593 rs2540493 chr12:96415842 A/C cg09636302 chr12:96389483 HAL -0.51 -6.28 -0.33 1.05e-9 Metabolite levels (small molecules and protein measures); CRC cis rs514406 0.755 rs11206015 chr1:53242187 T/C cg08859206 chr1:53392774 SCP2 0.43 6.9 0.36 2.7e-11 Monocyte count; CRC cis rs3996993 0.752 rs4538706 chr6:52694305 C/T cg20803780 chr6:52668592 GSTA1 0.36 6.39 0.33 5.8e-10 Hemoglobin concentration; CRC cis rs4253772 0.591 rs73886791 chr22:46687212 A/G cg24881330 chr22:46731750 TRMU 0.68 8.73 0.43 1.29e-16 LDL cholesterol;Cholesterol, total; CRC cis rs908922 0.676 rs12059256 chr1:152515431 G/A cg23254163 chr1:152506842 NA 0.44 8.62 0.43 2.8e-16 Hair morphology; CRC cis rs7605827 0.930 rs10203196 chr2:15541154 A/T cg19274914 chr2:15703543 NA 0.4 5.92 0.31 8.18e-9 Educational attainment (years of education); CRC cis rs694739 0.595 rs11542299 chr11:64138805 T/C cg02228329 chr11:64053129 BAD;GPR137 0.48 6.51 0.34 2.75e-10 Alopecia areata;Crohn's disease;Psoriasis vulgaris; CRC cis rs7914558 0.901 rs1926034 chr10:104829102 G/A cg04362960 chr10:104952993 NT5C2 0.59 8.72 0.43 1.43e-16 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs72781680 1.000 rs12617839 chr2:24166277 A/T cg08917208 chr2:24149416 ATAD2B 0.91 9.24 0.45 3.06e-18 Lymphocyte counts; CRC cis rs62064224 0.714 rs11653974 chr17:30635002 T/C cg09324608 chr17:30823087 MYO1D 0.36 6.31 0.33 8.91e-10 Schizophrenia; CRC cis rs13118159 0.550 rs28733902 chr4:1374789 A/G cg05025164 chr4:1340916 KIAA1530 0.57 8.1 0.41 1.11e-14 Longevity; CRC cis rs6838801 0.892 rs28515950 chr4:77575939 A/G cg17476223 chr4:77663285 SHROOM3 0.42 5.9 0.31 9.22e-9 Cleft lip with or without cleft palate; CRC cis rs2658782 0.666 rs2925361 chr11:93098823 G/A cg15737290 chr11:93063684 CCDC67 0.48 7.0 0.36 1.44e-11 Pulmonary function decline; CRC cis rs1046896 0.520 rs8074086 chr17:80818460 A/C cg19046167 chr17:80928561 B3GNTL1 0.52 7.42 0.38 1.04e-12 Glycated hemoglobin levels; CRC cis rs6952809 1.000 rs28712717 chr7:2449590 T/C cg23289794 chr7:2394357 EIF3B -0.41 -5.68 -0.3 2.96e-8 Multiple sclerosis; CRC cis rs9322193 0.962 rs9688940 chr6:150110113 G/A cg07701084 chr6:150067640 NUP43 0.47 6.61 0.34 1.51e-10 Lung cancer; CRC cis rs6502050 0.787 rs7222326 chr17:80057272 T/C cg13939156 chr17:80058883 NA 0.37 5.71 0.3 2.52e-8 Life satisfaction; CRC cis rs4700695 0.719 rs27082 chr5:65436152 A/C cg21114390 chr5:65439923 SFRS12 -0.67 -8.93 -0.44 2.96e-17 Facial morphology (factor 19); CRC cis rs2932538 0.922 rs6537744 chr1:113096746 C/G cg22162597 chr1:113214053 CAPZA1 0.71 10.16 0.49 2.79e-21 Systolic blood pressure;Diastolic blood pressure;Hypertension;Blood pressure; CRC cis rs9892942 1 rs9892942 chr17:27178761 C/T cg12682573 chr17:27188876 MIR451;MIR144 0.59 8.33 0.42 2.24e-15 Mean corpuscular volume;Mean corpuscular hemoglobin; CRC cis rs921968 0.643 rs484085 chr2:219396684 C/T cg02176678 chr2:219576539 TTLL4 0.48 7.99 0.4 2.28e-14 Mean corpuscular hemoglobin concentration; CRC cis rs6809651 0.524 rs7622914 chr3:185790895 T/C cg00760338 chr3:185826511 ETV5 -0.69 -8.47 -0.42 8.08e-16 Body mass index in physically active individuals;Glomerular filtration rate (creatinine);Body mass index (joint analysis main effects and physical activity interaction);Body mass index;Body mass index in physically inactive individuals; CRC cis rs853679 0.517 rs9393898 chr6:28130376 G/T cg21251018 chr6:28226885 NKAPL 0.47 6.04 0.32 4.16e-9 Depression; CRC cis rs6456156 0.583 rs7748224 chr6:167456860 C/T cg07741184 chr6:167504864 NA 0.39 6.83 0.35 4.13e-11 Primary biliary cholangitis; CRC trans rs9393777 0.920 rs34071253 chr6:27391802 C/T cg06606381 chr12:133084897 FBRSL1 -0.93 -6.66 -0.34 1.17e-10 Intelligence (multi-trait analysis); CRC cis rs4803455 0.565 rs2241713 chr19:41869468 C/G cg09537434 chr19:41945824 ATP5SL 0.57 8.6 0.43 3.21e-16 Migraine;Coronary artery disease; CRC trans rs4650994 0.544 rs2811311 chr1:178617337 A/G cg05059571 chr16:84539110 KIAA1609 0.61 8.2 0.41 5.63e-15 HDL cholesterol levels;HDL cholesterol; CRC cis rs13082711 0.522 rs574955 chr3:27351000 T/C cg02860705 chr3:27208620 NA 0.46 6.88 0.35 3.03e-11 Systolic blood pressure;Diastolic blood pressure;Blood pressure; CRC cis rs6694672 0.850 rs857027 chr1:197013464 T/C cg13682187 chr1:196946512 CFHR5 0.47 7.41 0.38 1.07e-12 Asthma; CRC cis rs3733585 0.673 rs116046986 chr4:9957794 A/G cg11266682 chr4:10021025 SLC2A9 -0.47 -9.66 -0.47 1.31e-19 Cleft plate (environmental tobacco smoke interaction); CRC cis rs3008870 1.000 rs3008870 chr1:67418027 C/T cg08660285 chr1:67390436 MIER1;WDR78 1.02 15.1 0.64 1.6e-39 Lymphocyte percentage of white cells; CRC cis rs7394190 0.935 rs12570126 chr10:75416789 C/T cg26549892 chr10:75416844 SYNPO2L 0.51 6.61 0.34 1.59e-10 Incident atrial fibrillation; CRC cis rs6952808 0.723 rs60995052 chr7:2030007 G/C cg21782813 chr7:2030301 MAD1L1 0.54 9.44 0.46 7.29e-19 Bipolar disorder and schizophrenia; CRC cis rs477895 0.653 rs66648159 chr11:63899429 G/A cg19465662 chr11:63993652 NUDT22;TRPT1 0.73 8.97 0.44 2.22e-17 Mean platelet volume; CRC cis rs2115630 1.000 rs6496441 chr15:85363348 A/G cg09876464 chr15:85330779 ZNF592 0.45 7.72 0.39 1.37e-13 P wave terminal force; CRC cis rs929354 0.739 rs1182439 chr7:157027367 G/A cg16102536 chr7:156981717 UBE3C -0.41 -6.91 -0.36 2.55e-11 Body mass index; CRC cis rs6840360 0.582 rs2724553 chr4:152321881 T/C cg09659197 chr4:152720779 NA 0.43 8.47 0.42 8.45e-16 Intelligence (multi-trait analysis); CRC cis rs2576037 0.899 rs2246877 chr18:44577005 A/G cg07416455 chr18:44543612 TCEB3CL;KATNAL2 0.57 8.16 0.41 7.17e-15 Personality dimensions; CRC cis rs7916697 0.520 rs12265247 chr10:70038398 A/G cg06988349 chr10:69991859 ATOH7 0.39 6.86 0.35 3.41e-11 Optic disc area; CRC cis rs1124376 0.935 rs12490215 chr3:20156185 A/G cg05072819 chr3:20081367 KAT2B 0.46 5.91 0.31 8.32e-9 Bipolar disorder and schizophrenia; CRC trans rs561341 0.882 rs2428337 chr17:30299467 C/T cg20587970 chr11:113659929 NA -1.43 -20.5 -0.75 9.58e-61 Hip circumference adjusted for BMI; CRC cis rs2439831 1.000 rs527921 chr15:43770416 G/T cg15269541 chr15:43626905 ADAL 0.49 6.1 0.32 3.01e-9 Lung cancer in ever smokers; CRC cis rs6951245 0.935 rs11763765 chr7:1060510 C/T cg18402987 chr7:1209562 NA 0.6 6.37 0.33 6.33e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs7829975 0.840 rs572366 chr8:8578794 A/T cg06636001 chr8:8085503 FLJ10661 0.57 8.91 0.44 3.68e-17 Mood instability; CRC cis rs853679 0.517 rs12332979 chr6:28141548 T/G cg15786705 chr6:28176104 NA 0.78 9.7 0.47 1.01e-19 Depression; CRC cis rs7587476 0.822 rs13018304 chr2:215682218 T/G cg04004882 chr2:215674386 BARD1 0.67 9.49 0.46 5e-19 Neuroblastoma; CRC trans rs1814175 0.817 rs7481230 chr11:49772235 G/A cg03929089 chr4:120376271 NA -0.94 -18.0 -0.7 6.48e-51 Height; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg00546180 chr10:103815814 C10orf76 0.5 6.98 0.36 1.63e-11 Response to antipsychotic treatment; CRC cis rs1005277 0.579 rs1740732 chr10:38491385 C/T cg17219203 chr10:38645113 HSD17B7P2 -0.41 -5.88 -0.31 9.99e-9 Extrinsic epigenetic age acceleration; CRC cis rs9487051 0.676 rs13195816 chr6:109598624 T/C cg21918786 chr6:109611834 NA -0.42 -7.38 -0.38 1.34e-12 Reticulocyte fraction of red cells; CRC cis rs782590 0.967 rs17798852 chr2:55805172 A/C cg18811423 chr2:55921094 PNPT1 0.79 14.64 0.63 1.03e-37 Metabolic syndrome; CRC cis rs806215 1.000 rs712703 chr7:127257498 C/T cg25922125 chr7:127225783 GCC1 -0.55 -6.11 -0.32 2.84e-9 Type 2 diabetes; CRC cis rs7589728 0.514 rs12465706 chr2:88467459 C/A cg07952391 chr2:88470173 THNSL2 0.66 6.77 0.35 5.88e-11 Plasma clusterin levels; CRC cis rs2153535 0.580 rs1414349 chr6:8472290 A/G cg21535247 chr6:8435926 SLC35B3 0.5 7.53 0.38 4.89e-13 Motion sickness; CRC cis rs1862618 0.526 rs2591963 chr5:56237135 T/A cg12311346 chr5:56204834 C5orf35 0.94 13.01 0.58 1.66e-31 Initial pursuit acceleration; CRC trans rs7690467 0.794 rs56286760 chr4:133404439 G/T cg19296258 chr17:78878799 RPTOR -0.46 -6.03 -0.32 4.37e-9 Eating disorders; CRC cis rs13191362 1.000 rs34052221 chr6:163160803 G/A cg23758597 chr6:163146217 PARK2 -0.7 -7.13 -0.37 6.26e-12 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg01777630 chr16:66914802 PDP2 0.49 6.69 0.35 9.38e-11 Response to antipsychotic treatment; CRC cis rs7412746 0.611 rs11803940 chr1:150685835 A/G cg18016565 chr1:150552671 MCL1 0.46 6.61 0.34 1.51e-10 Melanoma; CRC cis rs17209837 1.000 rs17149641 chr7:87086090 T/C cg00919237 chr7:87102261 ABCB4 -0.49 -6.03 -0.32 4.4e-9 Gallbladder cancer; CRC cis rs367615 0.513 rs11741087 chr5:108807760 G/A cg17395555 chr5:108820864 NA 0.45 8.8 0.44 7.98e-17 Colorectal cancer (SNP x SNP interaction); CRC cis rs2075371 0.611 rs11762920 chr7:134018514 C/T cg20476274 chr7:133979776 SLC35B4 0.53 7.72 0.39 1.38e-13 Mean platelet volume; CRC cis rs79387448 0.655 rs76930359 chr2:102924684 G/A cg09003973 chr2:102972529 NA 0.96 9.91 0.48 1.94e-20 Gut microbiota (bacterial taxa); CRC trans rs6550704 0.687 rs9865314 chr3:22634337 A/G cg20905760 chr15:43478003 CCNDBP1 -0.42 -6.2 -0.32 1.66e-9 Daytime sleep phenotypes; CRC cis rs832540 0.931 rs1445996 chr5:56235548 C/T cg18230493 chr5:56204884 C5orf35 0.4 5.91 0.31 8.57e-9 Coronary artery disease; CRC cis rs7659604 0.676 rs7691955 chr4:122700462 A/T cg19748678 chr4:122722346 EXOSC9 0.69 11.01 0.52 3.32e-24 Type 2 diabetes; CRC trans rs10982213 0.830 rs2274163 chr9:117188714 C/T cg06537201 chr12:58330115 NA 0.43 6.53 0.34 2.54e-10 Interleukin-6 levels; CRC cis rs796364 0.806 rs74771155 chr2:200913743 C/T cg25936922 chr2:200820526 C2orf60;C2orf47 -0.7 -6.57 -0.34 2.02e-10 Schizophrenia; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg16488639 chr12:12966464 DDX47 0.41 6.2 0.32 1.71e-9 Liver disease severity in Alagille syndrome; CRC trans rs17192198 0.661 rs73198552 chr12:90067938 T/C cg17836913 chr1:54723679 SSBP3 -0.46 -6.02 -0.31 4.59e-9 Diastolic blood pressure; CRC cis rs2797160 0.967 rs2747715 chr6:126007719 A/T cg05901451 chr6:126070800 HEY2 0.41 6.2 0.32 1.66e-9 Endometrial cancer; CRC cis rs7618915 0.547 rs1561337 chr3:52659963 C/T cg07507251 chr3:52567010 NT5DC2 0.4 5.8 0.3 1.56e-8 Bipolar disorder; CRC cis rs6570726 0.967 rs9403707 chr6:145800010 A/G cg05347473 chr6:146136440 FBXO30 0.41 6.43 0.33 4.38e-10 Lobe attachment (rater-scored or self-reported); CRC trans rs2055729 0.528 rs11987861 chr8:9742206 A/G cg06636001 chr8:8085503 FLJ10661 -0.57 -7.06 -0.36 1.02e-11 Multiple myeloma (hyperdiploidy); CRC trans rs35110281 0.776 rs62226866 chr21:45024186 T/C cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.51 8.67 0.43 2.02e-16 Mean corpuscular volume; CRC cis rs6951245 1.000 rs11763835 chr7:1094513 A/G cg04025307 chr7:1156635 C7orf50 0.63 6.75 0.35 6.54e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs1707322 1.000 rs785486 chr1:46575148 G/C cg06784218 chr1:46089804 CCDC17 -0.55 -9.66 -0.47 1.33e-19 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs17155006 0.746 rs401066 chr7:107747937 G/A cg05962710 chr7:107745446 LAMB4 -0.41 -7.44 -0.38 8.61e-13 Pneumococcal bacteremia; CRC cis rs9322193 0.962 rs9688750 chr6:149978769 T/C cg13206674 chr6:150067644 NUP43 0.59 8.49 0.42 6.99e-16 Lung cancer; CRC cis rs8031584 0.918 rs34095794 chr15:31269691 C/T cg08704250 chr15:31115839 NA -0.44 -8.3 -0.42 2.72e-15 Huntington's disease progression; CRC cis rs644799 1.000 rs651445 chr11:95539122 T/A cg25622487 chr11:95524042 FAM76B;CEP57 0.76 11.87 0.55 2.62e-27 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs12971120 1.000 rs2278162 chr18:72175814 A/G cg25817165 chr18:72167213 CNDP2 -0.65 -9.35 -0.46 1.38e-18 Refractive error; CRC cis rs4808199 0.948 rs8108647 chr19:19427623 A/G cg03709012 chr19:19516395 GATAD2A 0.98 11.43 0.53 1.06e-25 Nonalcoholic fatty liver disease; CRC cis rs7914558 0.902 rs7092200 chr10:104844872 T/C cg04362960 chr10:104952993 NT5C2 0.53 7.76 0.39 1.08e-13 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs2032447 0.670 rs71557318 chr6:26118570 T/C cg18357526 chr6:26021779 HIST1H4A -0.68 -10.19 -0.49 2.27e-21 Intelligence (multi-trait analysis); CRC cis rs1395 0.744 rs11126932 chr2:27476282 G/A cg14242246 chr2:27434262 C2orf28;SLC5A6 0.32 6.21 0.32 1.55e-9 Blood metabolite levels; CRC trans rs9567307 1 rs9567307 chr13:44471877 A/G cg17145862 chr1:211918768 LPGAT1 0.49 7.02 0.36 1.27e-11 Leprosy; CRC cis rs2882667 0.861 rs11242445 chr5:138417054 G/T cg04439458 chr5:138467593 SIL1 -0.31 -5.6 -0.3 4.42e-8 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs2569991 0.636 rs361223 chr3:12922526 T/C cg22481960 chr3:13008800 IQSEC1 -0.52 -6.59 -0.34 1.8e-10 Periodontitis (DPAL); CRC cis rs7927592 0.871 rs113020558 chr11:68296832 G/A cg16797656 chr11:68205561 LRP5 0.38 5.94 0.31 7.29e-9 Total body bone mineral density; CRC trans rs10983614 1.000 rs7867776 chr9:120072627 A/G cg22334543 chr19:3506226 FZR1 0.45 6.2 0.32 1.67e-9 Survival in pancreatic cancer; CRC cis rs7927592 0.731 rs10896350 chr11:68386373 A/C cg16797656 chr11:68205561 LRP5 0.49 8.94 0.44 2.88e-17 Total body bone mineral density; CRC cis rs3126085 0.935 rs4511113 chr1:152222192 G/A cg09127314 chr1:152161683 NA 0.46 5.93 0.31 7.69e-9 Atopic dermatitis; CRC trans rs11098499 0.874 rs6826823 chr4:120112098 G/C cg25214090 chr10:38739885 LOC399744 0.52 7.73 0.39 1.34e-13 Corneal astigmatism; CRC cis rs7258465 0.965 rs1560118 chr19:18570035 G/A cg01065977 chr19:18549689 ISYNA1 -0.42 -6.47 -0.34 3.54e-10 Breast cancer; CRC cis rs3824867 0.920 rs10742805 chr11:47454701 A/G cg05585544 chr11:47624801 NA -0.4 -6.33 -0.33 8.17e-10 Mean corpuscular hemoglobin; CRC cis rs1552244 0.935 rs35586456 chr3:10116938 A/G cg00166722 chr3:10149974 C3orf24 0.67 9.23 0.45 3.37e-18 Alzheimer's disease; CRC cis rs8016982 0.593 rs7160569 chr14:81713686 C/T cg01989461 chr14:81687754 GTF2A1 0.64 10.42 0.5 3.82e-22 Schizophrenia; CRC cis rs10894147 0.756 rs1783911 chr11:129753751 G/A cg27255275 chr11:129766154 NFRKB 0.41 5.61 0.3 4.21e-8 Obesity-related traits; CRC cis rs6951245 0.938 rs117729148 chr7:1108531 G/A cg22907277 chr7:1156413 C7orf50 0.74 7.89 0.4 4.63e-14 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs11997175 0.546 rs1561913 chr8:33587002 A/T cg04338863 chr8:33670619 NA 0.35 5.93 0.31 7.49e-9 Body mass index; CRC cis rs6456156 0.774 rs1012656 chr6:167525303 G/C cg05540913 chr6:167530185 CCR6 -0.35 -6.18 -0.32 1.85e-9 Primary biliary cholangitis; CRC cis rs2836950 0.545 rs2836940 chr21:40588696 T/C cg11644478 chr21:40555479 PSMG1 -0.49 -7.37 -0.38 1.41e-12 Menarche (age at onset); CRC cis rs2304069 0.695 rs6866298 chr5:149439588 A/G cg22760475 chr5:149380129 HMGXB3;TIGD6 0.66 8.18 0.41 6.29e-15 HIV-1 control; CRC cis rs4665809 0.590 rs1865324 chr2:26417533 C/A cg22920501 chr2:26401640 FAM59B -0.82 -11.68 -0.54 1.37e-26 Gut microbiome composition (summer); CRC cis rs11212617 1.000 rs228598 chr11:108107497 T/G cg01991180 chr11:108092276 ATM;NPAT 0.43 6.29 0.33 9.83e-10 Response to metformin in type 2 diabetes (glycemic); CRC cis rs172166 0.515 rs2622320 chr6:28115336 T/A cg10876282 chr6:28092338 ZSCAN16 0.4 5.71 0.3 2.52e-8 Cardiac Troponin-T levels; CRC cis rs16882447 0.607 rs28701873 chr5:53489782 G/A cg06461071 chr5:53490839 ARL15 0.34 5.6 0.3 4.48e-8 Systolic blood pressure (dietary potassium intake interaction); CRC cis rs116095464 0.614 rs78905930 chr5:246560 G/A cg22857025 chr5:266934 NA -1.22 -15.87 -0.66 1.61e-42 Breast cancer; CRC cis rs9311474 0.629 rs4282054 chr3:52566065 T/C cg07507251 chr3:52567010 NT5DC2 0.5 7.97 0.4 2.65e-14 Electroencephalogram traits; CRC cis rs12580194 0.593 rs11171416 chr12:55731490 A/G cg19537932 chr12:55886519 OR6C68 -0.65 -8.33 -0.42 2.18e-15 Cancer; CRC cis rs7216064 1.000 rs9915108 chr17:65874463 T/C cg12091567 chr17:66097778 LOC651250 -0.61 -7.68 -0.39 1.84e-13 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg09777506 chr15:69112064 ANP32A 0.46 6.87 0.35 3.29e-11 Liver disease severity in Alagille syndrome; CRC cis rs4237845 0.514 rs4760339 chr12:58268149 G/T cg00677455 chr12:58241039 CTDSP2 0.78 11.3 0.53 3.07e-25 Intelligence (multi-trait analysis); CRC cis rs7412746 0.658 rs72704652 chr1:150819470 A/G cg18016565 chr1:150552671 MCL1 0.44 6.03 0.32 4.31e-9 Melanoma; CRC cis rs6460942 0.908 rs6978857 chr7:12232665 A/G cg06484146 chr7:12443880 VWDE -0.58 -6.05 -0.32 4.03e-9 Coronary artery disease; CRC trans rs12599106 0.560 rs34151874 chr16:34989694 G/A cg01516881 chr6:292596 DUSP22 -0.66 -9.69 -0.47 1.07e-19 Menopause (age at onset); CRC cis rs651907 0.557 rs1031710 chr3:101463895 C/T cg12386194 chr3:101231763 SENP7 0.5 7.37 0.38 1.42e-12 Colorectal cancer; CRC cis rs4862750 0.872 rs6825289 chr4:187879109 T/G cg06074448 chr4:187884817 NA -0.58 -10.87 -0.51 9.87e-24 Lobe attachment (rater-scored or self-reported); CRC cis rs34172651 0.874 rs200534 chr16:24752641 G/A cg00339695 chr16:24857497 SLC5A11 -0.29 -6.59 -0.34 1.7e-10 Intelligence (multi-trait analysis); CRC cis rs7618915 0.547 rs11130311 chr3:52675005 T/C cg15147215 chr3:52552868 STAB1 -0.62 -10.24 -0.49 1.48e-21 Bipolar disorder; CRC cis rs7224314 1.000 rs7226214 chr17:65383323 C/T cg01507342 chr17:65387096 PITPNC1 -0.57 -8.05 -0.41 1.54e-14 Diisocyanate-induced asthma; CRC cis rs12594515 0.904 rs8032875 chr15:45998010 A/C cg22117107 chr15:45993392 NA -0.43 -8.65 -0.43 2.36e-16 Waist circumference;Weight; CRC cis rs6860806 0.631 rs4705931 chr5:131588345 T/C cg20512303 chr5:131592959 PDLIM4 0.37 7.05 0.36 1.05e-11 Breast cancer; CRC trans rs61931739 0.517 rs1843737 chr12:34015305 A/G cg26384229 chr12:38710491 ALG10B 0.5 6.99 0.36 1.58e-11 Morning vs. evening chronotype; CRC cis rs4660214 0.666 rs10493087 chr1:39717256 C/G cg11070191 chr1:39582205 MACF1 0.36 5.74 0.3 2.18e-8 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs9828933 0.577 rs704374 chr3:63865947 C/T cg16258503 chr3:63850278 ATXN7;THOC7 0.8 9.38 0.46 1.07e-18 Type 2 diabetes; CRC cis rs6582630 0.519 rs11181294 chr12:38312787 C/T cg13010199 chr12:38710504 ALG10B 0.47 6.29 0.33 1.01e-9 Drug-induced liver injury (flucloxacillin); CRC cis rs653465 0.679 rs12488954 chr3:27145162 G/A cg02860705 chr3:27208620 NA -0.36 -5.64 -0.3 3.61e-8 Breast cancer (early onset); CRC trans rs2243480 0.708 rs13242216 chr7:65898277 T/C cg10756647 chr7:56101905 PSPH 0.74 7.52 0.38 5.38e-13 Diabetic kidney disease; CRC cis rs6500602 0.701 rs4786500 chr16:4525265 A/G cg08645402 chr16:4508243 NA -0.48 -7.35 -0.38 1.56e-12 Schizophrenia; CRC cis rs2243480 0.666 rs1880311 chr7:65276752 G/C cg18252515 chr7:66147081 NA 1.22 13.63 0.6 7.6e-34 Diabetic kidney disease; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg07393458 chr17:57297757 GDPD1 0.42 6.04 0.32 4.1e-9 Intelligence (multi-trait analysis); CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg08303978 chr15:65822665 PTPLAD1 0.47 6.35 0.33 7.15e-10 Anxiety disorder; CRC cis rs4409675 0.576 rs6662916 chr1:28219873 G/T cg23691781 chr1:28212827 C1orf38 0.34 7.98 0.4 2.47e-14 Corneal astigmatism; CRC cis rs8180040 0.701 rs34103310 chr3:47073266 C/T cg27129171 chr3:47204927 SETD2 0.7 11.45 0.53 8.8e-26 Colorectal cancer; CRC cis rs10463316 0.894 rs3905511 chr5:150768204 G/A cg03212797 chr5:150827313 SLC36A1 -0.49 -7.74 -0.39 1.26e-13 Metabolite levels (Pyroglutamine); CRC cis rs12458462 0.892 rs58675823 chr18:77463672 G/A cg11879182 chr18:77439856 CTDP1 0.7 11.02 0.52 2.97e-24 Monocyte count; CRC cis rs10464366 0.544 rs4355688 chr7:39158402 C/T cg20302533 chr7:39170763 POU6F2 0.42 5.7 0.3 2.74e-8 IgG glycosylation; CRC cis rs6424115 0.931 rs2982390 chr1:24147830 G/C cg10978503 chr1:24200527 CNR2 0.5 8.68 0.43 1.86e-16 Immature fraction of reticulocytes; CRC cis rs13191362 1.000 rs13220181 chr6:163004401 T/A cg06582575 chr6:163149167 PACRG;PARK2 0.73 10.55 0.5 1.3e-22 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs7772486 0.790 rs1062067 chr6:146207563 A/G cg23711669 chr6:146136114 FBXO30 0.71 12.52 0.57 1.15e-29 Lobe attachment (rater-scored or self-reported); CRC cis rs9487051 0.872 rs9487042 chr6:109610443 T/G cg01475377 chr6:109611718 NA -0.49 -9.34 -0.46 1.52e-18 Reticulocyte fraction of red cells; CRC cis rs4919694 0.808 rs112574306 chr10:104971159 C/T cg04362960 chr10:104952993 NT5C2 1.18 9.39 0.46 1.06e-18 Arsenic metabolism; CRC cis rs9303401 0.538 rs10515155 chr17:56481944 A/G cg10487724 chr17:56770010 TEX14;RAD51C 0.73 8.78 0.44 8.89e-17 Cognitive test performance; CRC cis rs801193 1.000 rs4717310 chr7:66161007 C/T cg00343986 chr7:65444356 GUSB 0.5 7.38 0.38 1.34e-12 Aortic root size; CRC cis rs4713118 0.869 rs6901520 chr6:27714575 G/T cg21251018 chr6:28226885 NKAPL 0.38 5.73 0.3 2.24e-8 Parkinson's disease; CRC trans rs629535 0.862 rs2472141 chr8:70054216 T/C cg21567404 chr3:27674614 NA 0.96 16.23 0.67 6.5e-44 Dupuytren's disease; CRC cis rs7959452 0.590 rs11177619 chr12:69758871 G/A cg14784868 chr12:69753453 YEATS4 0.85 15.01 0.64 3.63e-39 Blood protein levels; CRC cis rs6963495 0.872 rs1569134 chr7:105158228 T/C cg13798780 chr7:105162888 PUS7 0.68 8.08 0.41 1.27e-14 Bipolar disorder (body mass index interaction); CRC cis rs7552404 0.961 rs1061337 chr1:76227022 A/G cg03433033 chr1:76189801 ACADM 0.81 11.14 0.52 1.13e-24 Blood metabolite levels;Acylcarnitine levels; CRC cis rs305851 0.716 rs7773103 chr6:39740391 C/G cg02386599 chr6:39769542 DAAM2 -0.37 -5.72 -0.3 2.36e-8 Lobe attachment (rater-scored or self-reported); CRC cis rs6502050 0.777 rs7406162 chr17:80086386 C/T cg22110888 chr17:80059540 CCDC57 -0.41 -6.39 -0.33 5.57e-10 Life satisfaction; CRC cis rs13256369 0.950 rs12548792 chr8:8568031 T/C cg06636001 chr8:8085503 FLJ10661 0.49 6.17 0.32 2.02e-9 Obesity-related traits; CRC trans rs35110281 0.591 rs86138 chr21:44932398 G/A cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.46 7.4 0.38 1.18e-12 Mean corpuscular volume; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg19317012 chr1:110880555 RBM15 0.38 6.16 0.32 2.1e-9 Liver disease severity in Alagille syndrome; CRC trans rs6833159 0.527 rs10939231 chr4:28829372 A/T cg19824334 chr17:73851399 WBP2 -0.42 -6.19 -0.32 1.78e-9 Underweight status; CRC cis rs172166 0.694 rs9295760 chr6:28147385 G/A cg25164649 chr6:28176230 NA 0.65 9.23 0.45 3.45e-18 Cardiac Troponin-T levels; CRC trans rs11764590 0.724 rs55669426 chr7:2090129 G/C cg11693508 chr17:37793320 STARD3 0.5 6.69 0.35 9.65e-11 Neuroticism; CRC cis rs8060686 0.516 rs10852439 chr16:68288331 T/C cg26727032 chr16:67993705 SLC12A4 -0.63 -9.22 -0.45 3.65e-18 HDL cholesterol;Metabolic syndrome; CRC cis rs10504229 0.683 rs73605816 chr8:58117167 T/C cg05313129 chr8:58192883 C8orf71 -0.43 -6.11 -0.32 2.74e-9 Developmental language disorder (linguistic errors); CRC cis rs46522 0.585 rs79049364 chr17:47014991 T/A cg22482690 chr17:47019901 SNF8 0.46 7.5 0.38 6.07e-13 Coronary heart disease; CRC trans rs9291683 0.530 rs73227883 chr4:9979279 T/C cg26043149 chr18:55253948 FECH 0.55 8.41 0.42 1.23e-15 Bone mineral density; CRC cis rs9303401 0.659 rs17822837 chr17:56737838 C/T cg10487724 chr17:56770010 TEX14;RAD51C 0.74 8.78 0.44 9.2e-17 Cognitive test performance; CRC cis rs1003719 0.788 rs1543749 chr21:38446621 A/G cg10648535 chr21:38446584 PIGP;TTC3 0.53 7.58 0.39 3.56e-13 Eye color traits; CRC cis rs3018066 0.867 rs12642691 chr4:107140732 C/T cg01869342 chr4:106983673 TBCK 0.36 5.74 0.3 2.11e-8 Cancer; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg23396286 chr10:99258505 UBTD1;MMS19 0.49 6.37 0.33 6.52e-10 Thyroid stimulating hormone; CRC cis rs2745967 0.740 rs2796252 chr1:208067308 C/A cg09788693 chr1:208063733 CD34 0.46 6.99 0.36 1.58e-11 Resting heart rate; CRC cis rs7666738 0.830 rs4699589 chr4:98973889 A/G cg05340658 chr4:99064831 C4orf37 0.6 9.35 0.46 1.41e-18 Colonoscopy-negative controls vs population controls; CRC cis rs8180040 0.654 rs9837343 chr3:47177388 C/T cg27129171 chr3:47204927 SETD2 0.73 11.57 0.54 3.45e-26 Colorectal cancer; CRC cis rs3540 1.000 rs6496678 chr15:91034456 A/G cg22089800 chr15:90895588 ZNF774 0.46 7.01 0.36 1.4e-11 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; CRC cis rs10193935 0.901 rs72800020 chr2:42655615 A/G cg27598129 chr2:42591480 NA -0.66 -7.68 -0.39 1.86e-13 Colonoscopy-negative controls vs population controls; CRC cis rs6502050 0.835 rs8075086 chr17:80092649 A/G cg09264619 chr17:80180166 NA -0.36 -6.04 -0.32 4.22e-9 Life satisfaction; CRC cis rs7584330 0.554 rs77648388 chr2:238431832 G/C cg14458575 chr2:238380390 NA 0.81 10.02 0.48 8.61e-21 Prostate cancer; CRC cis rs754466 0.606 rs11002308 chr10:79594796 A/T cg26805224 chr10:79626177 DLG5 -0.49 -7.08 -0.36 8.72e-12 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs9311474 0.713 rs352170 chr3:52236077 A/G cg15147215 chr3:52552868 STAB1 -0.52 -8.39 -0.42 1.41e-15 Electroencephalogram traits; CRC cis rs12928939 0.517 rs9940234 chr16:71964805 C/T cg03805757 chr16:71968109 PKD1L3 -0.53 -7.25 -0.37 2.95e-12 Post bronchodilator FEV1; CRC cis rs921968 0.565 rs3731876 chr2:219602819 G/A cg02176678 chr2:219576539 TTLL4 -0.43 -6.72 -0.35 8.24e-11 Mean corpuscular hemoglobin concentration; CRC cis rs8060686 0.623 rs2301814 chr16:68105171 C/G cg26727032 chr16:67993705 SLC12A4 -0.6 -9.35 -0.46 1.42e-18 HDL cholesterol;Metabolic syndrome; CRC cis rs7998202 0.667 rs188166 chr13:113355498 T/C cg02820901 chr13:113351484 ATP11A 0.61 6.65 0.34 1.2e-10 Glycated hemoglobin levels; CRC cis rs11212617 1.000 rs227077 chr11:108253252 C/T cg12106634 chr11:108092400 ATM;NPAT 0.43 6.53 0.34 2.46e-10 Response to metformin in type 2 diabetes (glycemic); CRC cis rs8180040 0.726 rs7610636 chr3:47064436 A/C cg10298567 chr3:47292165 KIF9 0.41 6.55 0.34 2.23e-10 Colorectal cancer; CRC cis rs7904368 0.806 rs3858182 chr10:16855094 C/T cg23933602 chr10:16859644 RSU1 0.53 5.84 0.31 1.23e-8 Ratio of the peak velocity of the mitral E-Wave divided by the peak velocity of the mitral A-wave.; CRC cis rs12908161 0.959 rs62019472 chr15:85331493 A/G cg17507749 chr15:85114479 UBE2QP1 0.63 8.87 0.44 4.74e-17 Schizophrenia; CRC cis rs10197940 0.578 rs1061305 chr2:152346979 T/C cg19508488 chr2:152266495 RIF1 0.46 6.63 0.34 1.41e-10 Lung cancer; CRC cis rs7647973 0.922 rs6809851 chr3:49309787 C/A cg07636037 chr3:49044803 WDR6 0.54 6.35 0.33 7.13e-10 Menarche (age at onset); CRC cis rs16858210 0.874 rs11918588 chr3:183601715 C/A cg25686905 chr3:183603175 PARL -0.45 -6.41 -0.33 4.9e-10 Menopause (age at onset); CRC cis rs7224685 0.501 rs781842 chr17:3958955 C/T cg05562828 chr17:3906858 NA 0.66 12.32 0.56 6.19e-29 Type 2 diabetes; CRC cis rs17362650 1.000 rs13032333 chr2:9620701 T/A cg12832956 chr2:9616023 IAH1 -0.51 -6.17 -0.32 1.99e-9 Alcohol dependence (age at onset); CRC cis rs13064411 0.627 rs9825827 chr3:113182231 T/C cg18753928 chr3:113234510 CCDC52 -0.66 -10.34 -0.5 6.91e-22 Response to simvastatin treatment (PCSK9 protein level change); CRC cis rs1775148 1 rs1775148 chr1:205757824 C/T cg24503407 chr1:205819492 PM20D1 0.4 5.9 0.31 8.81e-9 Prostate cancer; CRC cis rs9826463 0.582 rs11720007 chr3:142134712 T/G cg20824294 chr3:142316082 PLS1 0.35 5.64 0.3 3.61e-8 QRS duration in Tripanosoma cruzi seropositivity; CRC cis rs9303401 0.614 rs34843288 chr17:57103140 T/C cg02118635 chr17:56770003 RAD51C;TEX14 0.81 9.37 0.46 1.17e-18 Cognitive test performance; CRC cis rs9916302 0.718 rs10445306 chr17:37591422 A/G cg07936489 chr17:37558343 FBXL20 -0.83 -13.1 -0.59 7.34e-32 Glomerular filtration rate (creatinine); CRC cis rs748404 0.660 rs694725 chr15:43756210 A/G cg02155558 chr15:43621948 ADAL;LCMT2 0.52 7.68 0.39 1.9e-13 Lung cancer; CRC cis rs35883536 0.647 rs1995142 chr1:101041174 G/A cg06223162 chr1:101003688 GPR88 0.34 6.32 0.33 8.46e-10 Monocyte count; CRC cis rs2522056 1.000 rs62385693 chr5:131773674 T/C cg24060327 chr5:131705240 SLC22A5 0.43 5.89 0.31 9.44e-9 Lymphocyte counts;Fibrinogen; CRC cis rs11764590 0.715 rs11760737 chr7:2104055 T/C cg21155852 chr7:2048760 MAD1L1 -0.45 -5.97 -0.31 6.15e-9 Neuroticism; CRC cis rs17767392 0.781 rs2108057 chr14:72022750 G/A cg13720639 chr14:72061746 SIPA1L1 0.5 6.38 0.33 6.06e-10 Mitral valve prolapse; CRC cis rs2281845 0.826 rs4915214 chr1:201076290 T/A cg17810781 chr1:201082982 CACNA1S 0.41 6.8 0.35 5.06e-11 Permanent tooth development; CRC cis rs11098499 0.743 rs10003567 chr4:120241674 C/T cg24375607 chr4:120327624 NA 0.48 7.61 0.39 2.87e-13 Corneal astigmatism; CRC cis rs2243480 1.000 rs1715235 chr7:65488394 T/C cg12463550 chr7:65579703 CRCP 0.7 6.44 0.33 4.33e-10 Diabetic kidney disease; CRC cis rs2243480 1.000 rs437889 chr7:65509234 G/A cg18252515 chr7:66147081 NA -1.19 -13.2 -0.59 3.1e-32 Diabetic kidney disease; CRC cis rs6502050 0.764 rs7215277 chr17:80159283 C/A cg02741985 chr17:80059408 CCDC57 0.42 6.93 0.36 2.24e-11 Life satisfaction; CRC cis rs763121 0.853 rs1043441 chr22:39130964 C/T cg06544989 chr22:39130855 UNC84B 0.45 6.81 0.35 4.72e-11 Menopause (age at onset); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg04266864 chr17:27224823 FLOT2;DHRS13 0.39 5.98 0.31 5.73e-9 Liver disease severity in Alagille syndrome; CRC cis rs1008375 0.931 rs6449326 chr4:17699790 G/T cg16339924 chr4:17578868 LAP3 0.5 6.59 0.34 1.77e-10 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs1218582 0.741 rs7544528 chr1:154844585 C/T cg09359103 chr1:154839909 KCNN3 -0.75 -13.41 -0.59 5.22e-33 Prostate cancer; CRC cis rs12479064 0.724 rs3792143 chr2:100057020 C/T cg26064155 chr2:99771622 LIPT1;TSGA10 -0.64 -7.56 -0.38 4.12e-13 Chronic sinus infection; CRC cis rs6952808 0.792 rs13224989 chr7:1953766 C/G cg00106254 chr7:1943704 MAD1L1 -0.47 -6.92 -0.36 2.31e-11 Bipolar disorder and schizophrenia; CRC trans rs1147246 0.714 rs323851 chr12:125878105 G/A cg23470196 chr14:102695671 RAGE 0.41 6.01 0.31 4.95e-9 Amyotrophic lateral sclerosis (sporadic); CRC cis rs881375 0.867 rs10818484 chr9:123661194 C/T cg09419670 chr9:123605666 PSMD5;LOC253039 0.6 8.79 0.44 8.51e-17 Rheumatoid arthritis; CRC cis rs7647973 0.600 rs12631989 chr3:49273996 C/T cg07636037 chr3:49044803 WDR6 0.83 12.78 0.58 1.18e-30 Menarche (age at onset); CRC cis rs9747201 0.962 rs62079995 chr17:80076624 C/T cg02741985 chr17:80059408 CCDC57 -0.44 -5.95 -0.31 6.93e-9 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs56114371 0.568 rs200468 chr6:27757855 C/G cg03623178 chr6:28175578 NA 0.56 6.54 0.34 2.34e-10 Breast cancer; CRC cis rs853679 0.517 rs9468298 chr6:28122345 A/G cg12172441 chr6:28176163 NA 0.64 7.53 0.38 5.03e-13 Depression; CRC cis rs1707322 0.717 rs3014249 chr1:46079493 A/G cg06784218 chr1:46089804 CCDC17 -0.66 -12.06 -0.55 5.6e-28 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs3857536 0.611 rs6927407 chr6:66870010 T/C cg07460842 chr6:66804631 NA -0.49 -6.54 -0.34 2.3e-10 Blood trace element (Cu levels); CRC cis rs2576037 0.899 rs2571034 chr18:44578565 A/G cg19077165 chr18:44547161 KATNAL2 0.51 8.01 0.4 2.03e-14 Personality dimensions; CRC cis rs34172651 0.917 rs200536 chr16:24749203 G/A cg06028605 chr16:24865363 SLC5A11 -0.44 -7.92 -0.4 3.66e-14 Intelligence (multi-trait analysis); CRC trans rs1997103 1.000 rs2177804 chr7:55410302 G/A cg20935933 chr6:143382018 AIG1 0.51 6.65 0.34 1.25e-10 QRS interval (sulfonylurea treatment interaction); CRC cis rs1348850 0.914 rs1453370 chr2:178327727 C/T cg22681709 chr2:178499509 PDE11A -0.4 -7.3 -0.37 2.19e-12 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs11626933 0.851 rs2282031 chr14:90730943 A/G cg14092571 chr14:90743983 NA -0.65 -10.31 -0.49 8.8e-22 Gut microbiota (bacterial taxa); CRC cis rs7618915 0.547 rs11130313 chr3:52676190 A/C cg10802521 chr3:52805072 NEK4 -0.58 -9.0 -0.44 1.8e-17 Bipolar disorder; CRC cis rs1552244 0.882 rs35056669 chr3:10014171 C/T cg13047869 chr3:10149882 C3orf24 0.51 6.97 0.36 1.74e-11 Alzheimer's disease; CRC trans rs7615952 0.512 rs11929125 chr3:125359443 G/A cg00769240 chr8:12517080 NA -0.74 -10.23 -0.49 1.64e-21 Blood pressure (smoking interaction); CRC cis rs9814567 0.806 rs2888670 chr3:134326684 G/A cg06109529 chr3:134205091 CEP63;ANAPC13 -0.67 -9.64 -0.47 1.56e-19 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC trans rs205391 0.689 rs205412 chr16:28064827 A/G cg05844366 chr10:91738713 NA 0.46 5.97 0.31 6.07e-9 Obesity-related traits; CRC cis rs4727027 0.870 rs1568945 chr7:148874112 T/G cg12479418 chr7:148823350 ZNF425;ZNF398 0.43 5.88 0.31 1.02e-8 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC cis rs853679 0.517 rs9393901 chr6:28136797 A/G cg21251018 chr6:28226885 NKAPL 0.48 6.17 0.32 2.02e-9 Depression; CRC cis rs10946940 0.632 rs9366698 chr6:27672035 C/G cg08798685 chr6:27730294 NA -0.46 -6.26 -0.33 1.17e-9 Systemic lupus erythematosus; CRC cis rs7591163 1.000 rs2056566 chr2:228713241 G/A cg14329157 chr2:228736135 WDR69 -0.47 -6.53 -0.34 2.48e-10 Blood pressure; CRC cis rs9467773 0.587 rs3208733 chr6:26414425 C/T cg09904177 chr6:26538194 HMGN4 -0.45 -6.27 -0.33 1.13e-9 Intelligence (multi-trait analysis); CRC cis rs2204008 0.713 rs12366709 chr12:38210179 G/A cg26384229 chr12:38710491 ALG10B 0.69 9.26 0.45 2.81e-18 Bladder cancer; CRC cis rs4808199 0.947 rs7250658 chr19:19571100 A/G cg03709012 chr19:19516395 GATAD2A 0.99 11.71 0.54 9.98e-27 Nonalcoholic fatty liver disease; CRC cis rs7731657 0.537 rs4705851 chr5:130220592 A/G cg08523029 chr5:130500466 HINT1 0.43 5.68 0.3 2.95e-8 Fasting plasma glucose; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg16618003 chr1:65432492 JAK1 0.48 6.23 0.32 1.46e-9 Thyroid stimulating hormone; CRC cis rs3106136 0.967 rs12645192 chr4:95181525 C/T cg11021082 chr4:95130006 SMARCAD1 -0.46 -7.17 -0.37 5.09e-12 Capecitabine sensitivity; CRC cis rs9650657 0.571 rs4240673 chr8:10787612 T/C cg27411982 chr8:10470053 RP1L1 -0.4 -6.1 -0.32 3.05e-9 Neuroticism; CRC cis rs9905704 0.813 rs304269 chr17:56802059 A/G cg12560992 chr17:57184187 TRIM37 -0.51 -7.45 -0.38 8.55e-13 Testicular germ cell tumor; CRC cis rs763014 0.932 rs2269560 chr16:682442 A/C cg08989290 chr16:615782 NHLRC4 0.49 9.38 0.46 1.08e-18 Height; CRC cis rs7309 0.935 rs10930013 chr2:162070325 G/A cg22496339 chr2:162101262 NA 0.77 12.87 0.58 5.7e-31 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Educational attainment; CRC cis rs2576037 0.526 rs10853545 chr18:44475220 A/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.55 9.27 0.46 2.43e-18 Personality dimensions; CRC cis rs6546324 0.921 rs1430788 chr2:67868412 C/T cg15745817 chr2:67799979 NA -0.29 -5.7 -0.3 2.7e-8 Endometriosis; CRC cis rs13108904 0.901 rs6826029 chr4:1307689 A/G cg16405210 chr4:1374714 KIAA1530 -0.39 -5.65 -0.3 3.51e-8 Obesity-related traits; CRC cis rs1348850 0.872 rs4893825 chr2:178298687 A/G cg27490568 chr2:178487706 NA 0.42 6.28 0.33 1.06e-9 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs916888 0.779 rs199498 chr17:44865603 A/G cg15921436 chr17:44337874 NA 0.56 6.49 0.34 3.16e-10 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs11098499 0.739 rs951570 chr4:120150467 T/C cg09307838 chr4:120376055 NA -0.54 -8.48 -0.42 7.7e-16 Corneal astigmatism; CRC cis rs887829 0.569 rs4399719 chr2:234666461 T/G cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.45 -7.07 -0.36 9.07e-12 Metabolic traits;Bilirubin levels;Cholelithiasis-related traits in sickle cell anemia;Metabolite levels;Total bilirubin levels in HIV-1 infection;Serum metabolite levels;Blood metabolite levels; CRC cis rs6089584 0.888 rs6061983 chr20:60621202 T/C cg18761221 chr20:60518478 NA 0.44 7.14 0.37 5.92e-12 Body mass index; CRC cis rs2304069 0.954 rs1433010 chr5:149383954 C/G cg22760475 chr5:149380129 HMGXB3;TIGD6 -0.86 -10.22 -0.49 1.8e-21 HIV-1 control; CRC cis rs12745968 0.589 rs7541942 chr1:93021364 G/T cg17283838 chr1:93427260 FAM69A -0.44 -6.02 -0.32 4.61e-9 Bipolar disorder and schizophrenia; CRC cis rs7589728 0.563 rs4972044 chr2:88466196 T/C cg07952391 chr2:88470173 THNSL2 0.66 6.77 0.35 5.88e-11 Plasma clusterin levels; CRC cis rs7020830 0.931 rs13288178 chr9:37107799 A/G cg14294708 chr9:37120828 ZCCHC7 1.16 23.76 0.79 2.33e-73 Schizophrenia; CRC trans rs2228479 0.850 rs62052212 chr16:89981960 G/A cg24644049 chr4:85504048 CDS1 0.8 7.12 0.37 6.78e-12 Skin colour saturation; CRC cis rs11997175 0.603 rs66828270 chr8:33790155 C/G cg04338863 chr8:33670619 NA 0.42 6.39 0.33 5.83e-10 Body mass index; CRC cis rs8105895 0.935 rs7252550 chr19:22246017 C/T cg02657401 chr19:22469223 NA -0.34 -5.65 -0.3 3.56e-8 Body mass index (change over time); CRC cis rs2895526 0.668 rs10752272 chr10:12715060 G/T cg00115178 chr10:12648176 CAMK1D 0.35 5.71 0.3 2.56e-8 Headache; CRC cis rs611744 0.573 rs629996 chr8:109255206 C/T cg18478394 chr8:109455254 TTC35 0.41 6.09 0.32 3.19e-9 Dupuytren's disease; CRC trans rs7976838 0.831 rs12824395 chr12:60129918 G/C cg16974014 chr22:22007515 MIR130B 0.49 6.0 0.31 5.21e-9 Response to zileuton treatment in asthma (FEV1 change interaction); CRC cis rs9322193 1.000 rs9399693 chr6:149933854 C/T cg00933542 chr6:150070202 PCMT1 0.29 5.95 0.31 6.7e-9 Lung cancer; CRC cis rs2976388 1.000 rs2920292 chr8:143765699 A/G cg20041105 chr8:143859282 LYNX1 -0.33 -5.76 -0.3 1.97e-8 Urinary tract infection frequency; CRC cis rs7258465 1.000 rs10442 chr19:18545341 A/C cg06953865 chr19:18549723 ISYNA1 -0.39 -5.76 -0.3 1.89e-8 Breast cancer; CRC trans rs62295889 0.602 rs62295918 chr4:12537011 G/A cg03490839 chr16:73082051 ZFHX3 0.58 6.06 0.32 3.82e-9 Obesity-related traits; CRC cis rs4780401 0.546 rs3743588 chr16:11836508 G/A cg01061890 chr16:11836724 TXNDC11 0.76 9.37 0.46 1.23e-18 Rheumatoid arthritis; CRC cis rs870825 0.616 rs6552809 chr4:185643984 G/A cg04058563 chr4:185651563 MLF1IP 0.71 9.34 0.46 1.54e-18 Blood protein levels; CRC cis rs172166 0.516 rs2622322 chr6:28117443 C/G cg15786705 chr6:28176104 NA 0.48 7.21 0.37 3.76e-12 Cardiac Troponin-T levels; CRC cis rs4664293 0.867 rs3771721 chr2:160628155 C/G cg08347373 chr2:160653686 CD302 -0.47 -7.43 -0.38 9.32e-13 Monocyte percentage of white cells; CRC cis rs853679 0.574 rs1233705 chr6:28166447 C/G cg21251018 chr6:28226885 NKAPL 0.46 6.57 0.34 1.97e-10 Depression; CRC trans rs9291683 0.530 rs4697698 chr4:9942577 C/T cg26043149 chr18:55253948 FECH 0.52 7.92 0.4 3.67e-14 Bone mineral density; CRC trans rs1728785 1.000 rs1728773 chr16:68563644 A/C cg04657470 chr2:198365150 HSPE1;HSPD1 0.57 6.78 0.35 5.72e-11 Ulcerative colitis; CRC cis rs60871478 0.636 rs6976929 chr7:901382 C/T cg13798912 chr7:905769 UNC84A -0.63 -6.82 -0.35 4.44e-11 Cerebrospinal P-tau181p levels; CRC cis rs35110281 0.774 rs2838323 chr21:44999086 G/A cg01579765 chr21:45077557 HSF2BP -0.35 -6.67 -0.35 1.09e-10 Mean corpuscular volume; CRC cis rs11212617 1.000 rs7943165 chr11:108274890 T/C cg14761454 chr11:108092087 ATM;NPAT 0.44 6.67 0.35 1.07e-10 Response to metformin in type 2 diabetes (glycemic); CRC cis rs7945705 0.747 rs2653605 chr11:8993309 C/G cg12365402 chr11:9010492 NRIP3 -0.56 -10.65 -0.51 5.72e-23 Hemoglobin concentration; CRC cis rs2032447 1.000 rs2032447 chr6:26044369 A/G cg26028573 chr6:26043587 HIST1H2BB 0.46 7.08 0.36 8.6e-12 Intelligence (multi-trait analysis); CRC cis rs6502050 0.761 rs9908277 chr17:80060829 T/C cg25804541 chr17:80189381 SLC16A3 0.31 5.93 0.31 7.6e-9 Life satisfaction; CRC cis rs34375054 0.624 rs12580033 chr12:125676083 A/T cg05341575 chr12:125625032 AACS -0.4 -5.74 -0.3 2.14e-8 Post bronchodilator FEV1/FVC ratio; CRC trans rs875971 0.660 rs2191268 chr7:66110224 C/T cg00261552 chr12:12764894 CREBL2 -0.4 -6.02 -0.31 4.62e-9 Aortic root size; CRC cis rs734999 0.505 rs4445406 chr1:2539400 T/C cg18854424 chr1:2615690 NA 0.41 7.87 0.4 5.04e-14 Ulcerative colitis; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg04417954 chr15:91073943 CRTC3 0.48 6.11 0.32 2.75e-9 Thyroid stimulating hormone; CRC cis rs8180040 0.903 rs11710013 chr3:47296921 T/C cg27129171 chr3:47204927 SETD2 0.62 9.75 0.47 6.78e-20 Colorectal cancer; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg12692042 chr18:30050872 FAM59A 0.44 6.01 0.31 4.99e-9 Anxiety disorder; CRC cis rs2836974 0.623 rs7280326 chr21:40700408 A/G cg11890956 chr21:40555474 PSMG1 -0.8 -12.39 -0.56 3.3600000000000003e-29 Cognitive function; CRC cis rs2635047 0.783 rs9948677 chr18:44790343 G/A cg19077165 chr18:44547161 KATNAL2 -0.4 -6.19 -0.32 1.83e-9 Educational attainment; CRC cis rs7552404 0.924 rs7550974 chr1:76204185 A/G cg22875332 chr1:76189707 ACADM 0.8 11.87 0.55 2.65e-27 Blood metabolite levels;Acylcarnitine levels; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg27583038 chr1:234735904 NA 0.4 6.19 0.32 1.8e-9 Liver disease severity in Alagille syndrome; CRC cis rs9807989 0.839 rs6749114 chr2:102967587 A/C cg03938978 chr2:103052716 IL18RAP 0.37 5.97 0.31 6.2e-9 Asthma; CRC cis rs853679 0.517 rs1904840 chr6:28108232 C/T cg06470822 chr6:28175283 NA 1.03 13.59 0.6 1.04e-33 Depression; CRC cis rs4713118 0.621 rs4713134 chr6:28034121 T/C cg18032046 chr6:28092343 ZSCAN16 -0.47 -5.6 -0.3 4.53e-8 Parkinson's disease; CRC trans rs1814175 0.715 rs11040586 chr11:49858432 T/A cg21153622 chr11:89784906 NA -0.38 -6.2 -0.32 1.74e-9 Height; CRC cis rs6951245 0.935 rs11766669 chr7:1063593 C/T cg26224354 chr7:1096374 C7orf50;GPR146 -0.87 -10.89 -0.51 8.47e-24 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs9443645 0.901 rs2174743 chr6:79591805 G/A cg05283184 chr6:79620031 NA -0.58 -9.37 -0.46 1.19e-18 Intelligence (multi-trait analysis); CRC cis rs4731207 0.698 rs6963177 chr7:124444604 T/A cg23710748 chr7:124431027 NA 0.37 5.96 0.31 6.53e-9 Cutaneous malignant melanoma; CRC cis rs12701220 0.520 rs7803208 chr7:1162084 C/T cg02733842 chr7:1102375 C7orf50 -0.46 -6.29 -0.33 1.01e-9 Bronchopulmonary dysplasia; CRC cis rs8077889 1.000 rs2079005 chr17:41865627 T/G cg25876840 chr17:41920477 NA 0.56 7.59 0.39 3.26e-13 Triglycerides; CRC cis rs4332037 0.707 rs4721096 chr7:1877311 T/C cg23422044 chr7:1970798 MAD1L1 0.5 6.29 0.33 1.02e-9 Bipolar disorder; CRC cis rs651907 0.535 rs11707250 chr3:101509371 A/T cg11279151 chr3:101281821 RG9MTD1 0.53 7.1 0.36 7.68e-12 Colorectal cancer; CRC cis rs12541635 0.677 rs1496183 chr8:107024445 C/T cg10147462 chr8:107024639 NA 0.58 10.66 0.51 5.31e-23 Age of smoking initiation; CRC cis rs7705042 0.897 rs12515668 chr5:141496090 G/T cg08523384 chr5:141488047 NDFIP1 -0.33 -5.88 -0.31 9.9e-9 Asthma; CRC cis rs9463078 0.605 rs17339124 chr6:44942577 C/G cg25276700 chr6:44698697 NA 0.25 6.22 0.32 1.5e-9 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; CRC cis rs2276314 0.857 rs9304155 chr18:33585710 A/C cg19628046 chr18:33552617 C18orf21 0.54 7.4 0.38 1.14e-12 Endometriosis;Drug-induced torsades de pointes; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg16257247 chr11:62554234 TMEM179B;TAF6L 0.44 6.46 0.34 3.67e-10 Intelligence (multi-trait analysis); CRC cis rs2067615 0.560 rs4964485 chr12:107121952 A/G cg13491945 chr12:107078410 RFX4 0.34 5.87 0.31 1.09e-8 Heart rate; CRC cis rs3741151 0.773 rs113465107 chr11:73210416 T/G cg17517138 chr11:73019481 ARHGEF17 1.01 8.32 0.42 2.41e-15 GIP levels in response to oral glucose tolerance test (120 minutes); CRC cis rs34375054 0.660 rs900411 chr12:125612839 C/T cg05341575 chr12:125625032 AACS -0.37 -5.94 -0.31 7.33e-9 Post bronchodilator FEV1/FVC ratio; CRC cis rs2019137 0.560 rs7578633 chr2:113978650 C/T cg25243455 chr2:114033360 PAX8;LOC440839 -0.31 -7.28 -0.37 2.45e-12 Lymphocyte counts; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg02700454 chr8:126441997 TRIB1 0.45 6.39 0.33 5.8e-10 Anxiety disorder; CRC cis rs7635838 0.619 rs346087 chr3:11274354 A/G cg00170343 chr3:11313890 ATG7 0.53 7.89 0.4 4.39e-14 HDL cholesterol; CRC cis rs2153535 0.580 rs7766852 chr6:8472417 C/T cg21535247 chr6:8435926 SLC35B3 0.49 7.49 0.38 6.5e-13 Motion sickness; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg17101748 chr1:224517614 NVL 0.5 6.54 0.34 2.38e-10 Thyroid stimulating hormone; CRC cis rs4843747 0.671 rs8053377 chr16:88106465 A/G cg03395651 chr16:88107091 BANP 0.6 8.16 0.41 7.06e-15 Menopause (age at onset); CRC cis rs4076764 0.957 rs4443867 chr1:163434917 T/C cg06092702 chr1:163392909 NA -0.57 -8.86 -0.44 5.21e-17 Motion sickness; CRC cis rs4727027 0.899 rs11771339 chr7:148854132 A/T cg23583168 chr7:148888333 NA -0.93 -16.29 -0.67 3.69e-44 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC trans rs10504229 0.953 rs116564484 chr8:58172818 T/C cg04077850 chr5:125800366 GRAMD3 0.36 6.13 0.32 2.47e-9 Developmental language disorder (linguistic errors); CRC cis rs7523050 0.643 rs34801874 chr1:109404382 C/T cg08274380 chr1:109419600 GPSM2 0.86 6.9 0.36 2.74e-11 Fat distribution (HIV); CRC cis rs6598955 0.671 rs10493030 chr1:26561856 T/C cg04990556 chr1:26633338 UBXN11 0.54 5.85 0.31 1.19e-8 Obesity-related traits; CRC cis rs7202877 0.656 rs37596 chr16:75498320 C/A cg03315344 chr16:75512273 CHST6 -0.48 -6.21 -0.32 1.58e-9 Type 2 diabetes;Type 1 diabetes; CRC cis rs7945705 0.902 rs10743095 chr11:8936984 T/C cg12365402 chr11:9010492 NRIP3 0.45 7.3 0.37 2.14e-12 Hemoglobin concentration; CRC trans rs7267979 0.816 rs8115257 chr20:25207931 A/G cg17903999 chr18:56338584 MALT1 -0.38 -6.02 -0.31 4.66e-9 Liver enzyme levels (alkaline phosphatase); CRC cis rs9388451 1.000 rs9388451 chr6:126090377 A/G cg10911889 chr6:126070802 HEY2 0.37 5.72 0.3 2.34e-8 Brugada syndrome; CRC cis rs7762018 0.769 rs4716385 chr6:170127608 G/T cg19338460 chr6:170058176 WDR27 -0.85 -8.59 -0.43 3.59e-16 Thiazide-induced adverse metabolic effects in hypertensive patients; CRC cis rs873946 0.648 rs3793673 chr10:134547732 A/C cg26818010 chr10:134567672 INPP5A -0.64 -8.52 -0.43 5.77e-16 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CRC cis rs2645694 0.626 rs2645708 chr4:77822682 G/A cg06046430 chr4:77819534 ANKRD56 0.42 5.78 0.3 1.77e-8 Emphysema distribution in smoking; CRC cis rs7647973 0.516 rs4955419 chr3:49200692 T/A cg20833759 chr3:49053208 WDR6;DALRD3 0.37 6.1 0.32 2.97e-9 Menarche (age at onset); CRC cis rs2239547 0.522 rs2581779 chr3:53056199 T/C cg10802521 chr3:52805072 NEK4 0.44 5.98 0.31 5.68e-9 Schizophrenia; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg10159630 chr2:177037364 HOXD3 0.25 6.56 0.34 2.03e-10 Liver disease severity in Alagille syndrome; CRC cis rs28735056 0.565 rs12957336 chr18:77716889 A/G cg20368463 chr18:77673604 PQLC1 -0.49 -7.69 -0.39 1.7e-13 Schizophrenia; CRC trans rs11039798 0.545 rs7118670 chr11:48532056 C/T cg15704280 chr7:45808275 SEPT13 0.62 6.22 0.32 1.55e-9 Axial length; CRC cis rs113835537 0.935 rs1127145 chr11:66373305 G/A cg22134325 chr11:66188745 NPAS4 0.39 6.3 0.33 9.76e-10 Airway imaging phenotypes; CRC cis rs738322 0.839 rs133015 chr22:38572526 C/G cg17652424 chr22:38574118 PLA2G6 -0.22 -6.76 -0.35 6.36e-11 Cutaneous nevi; CRC cis rs4601821 0.823 rs10891546 chr11:113265292 C/T cg14159747 chr11:113255604 NA -0.52 -10.41 -0.5 3.87e-22 Alcoholic chronic pancreatitis; CRC cis rs3806843 0.801 rs801170 chr5:140115343 C/T cg19875535 chr5:140030758 IK -0.54 -8.81 -0.44 7.41e-17 Depressive symptoms (multi-trait analysis); CRC trans rs7267979 0.764 rs2474767 chr20:25246733 T/C cg17903999 chr18:56338584 MALT1 -0.41 -6.42 -0.33 4.79e-10 Liver enzyme levels (alkaline phosphatase); CRC cis rs6502050 0.835 rs35131307 chr17:80128439 G/A cg09264619 chr17:80180166 NA -0.34 -5.76 -0.3 1.93e-8 Life satisfaction; CRC cis rs2276314 0.512 rs1789506 chr18:33625370 G/A cg05985134 chr18:33552581 C18orf21 -0.38 -6.03 -0.32 4.44e-9 Endometriosis;Drug-induced torsades de pointes; CRC cis rs651907 0.557 rs35850993 chr3:101437433 A/G cg11279151 chr3:101281821 RG9MTD1 -0.48 -6.54 -0.34 2.41e-10 Colorectal cancer; CRC cis rs13108904 0.901 rs1680073 chr4:1280337 G/A cg19318889 chr4:1322082 MAEA -0.42 -6.47 -0.34 3.53e-10 Obesity-related traits; CRC cis rs7552404 0.727 rs1144336 chr1:76277421 C/A cg10523679 chr1:76189770 ACADM 0.65 8.8 0.44 7.66e-17 Blood metabolite levels;Acylcarnitine levels; CRC trans rs11098499 0.909 rs28793658 chr4:120307214 A/C cg25214090 chr10:38739885 LOC399744 0.62 9.7 0.47 1.01e-19 Corneal astigmatism; CRC cis rs7640424 0.716 rs35703078 chr3:107859558 A/G cg09227934 chr3:107805635 CD47 -0.43 -6.47 -0.34 3.56e-10 Body mass index; CRC cis rs10760158 0.800 rs10818520 chr9:124018673 A/T cg14417974 chr9:124058376 GSN -0.34 -5.7 -0.3 2.62e-8 Pulse pressure; CRC trans rs61101201 0.962 rs10835790 chr11:31610022 C/T cg25668320 chr4:144833231 NA -0.48 -6.32 -0.33 8.58e-10 Optic disc area; CRC cis rs889312 0.500 rs33328 chr5:56143419 T/C cg12311346 chr5:56204834 C5orf35 -0.47 -7.14 -0.37 5.86e-12 Breast cancer;Breast cancer (early onset); CRC cis rs6543140 0.601 rs6543135 chr2:103062406 C/T cg09003973 chr2:102972529 NA 0.52 6.33 0.33 8e-10 Blood protein levels; CRC cis rs892961 0.932 rs7208336 chr17:75412932 T/C cg05865280 chr17:75406074 SEPT9 0.63 14.51 0.62 3.27e-37 Airflow obstruction; CRC cis rs10486722 0.624 rs11765316 chr7:41773032 A/T cg22138096 chr7:41772439 LOC285954 0.39 5.89 0.31 9.49e-9 Pit-and-Fissure caries; CRC cis rs1005277 0.579 rs2472182 chr10:38388865 T/C cg00409905 chr10:38381863 ZNF37A -0.68 -11.32 -0.53 2.64e-25 Extrinsic epigenetic age acceleration; CRC cis rs8177253 0.763 rs8177224 chr3:133474003 C/G cg16262614 chr3:133464971 TF -0.35 -6.13 -0.32 2.58e-9 Iron status biomarkers; CRC cis rs1448094 0.534 rs11613070 chr12:86167544 T/A cg25456477 chr12:86230367 RASSF9 0.4 6.71 0.35 8.75e-11 Major depressive disorder; CRC cis rs2346160 0.899 rs172283 chr6:167691225 T/C cg04673565 chr6:167680447 NA -0.39 -6.33 -0.33 7.83e-10 Parental extreme longevity (95 years and older); CRC cis rs4665809 1.000 rs6749855 chr2:26255263 A/G cg22920501 chr2:26401640 FAM59B -0.5 -6.62 -0.34 1.44e-10 Gut microbiome composition (summer); CRC cis rs2274273 0.840 rs11547116 chr14:55738165 T/C cg23234261 chr14:55582407 NA -0.28 -5.86 -0.31 1.15e-8 Protein biomarker; CRC cis rs853679 0.517 rs4713150 chr6:28136212 G/A cg03623178 chr6:28175578 NA 0.98 12.63 0.57 4.44e-30 Depression; CRC cis rs7618501 0.521 rs34654589 chr3:49911449 C/G cg24110177 chr3:50126178 RBM5 -0.55 -8.04 -0.41 1.64e-14 Intelligence (multi-trait analysis); CRC cis rs754466 1.000 rs12220328 chr10:79681482 G/C cg17075019 chr10:79541650 NA -0.7 -9.76 -0.47 6.32e-20 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs7945718 0.967 rs10765989 chr11:12769397 A/G cg25843174 chr11:12811716 TEAD1 -0.45 -8.55 -0.43 4.78e-16 Educational attainment (years of education); CRC cis rs753955 0.592 rs7325382 chr13:24350093 T/C cg25267304 chr13:24462978 PCOTH;MIPEP -0.43 -5.98 -0.31 5.7e-9 Lung cancer; CRC cis rs457287 0.772 rs457944 chr9:4830789 C/G cg14182974 chr9:4791918 RCL1 -0.41 -5.75 -0.3 2.08e-8 Platelet count; CRC trans rs66759488 0.739 rs10851451 chr15:47608991 A/G cg14168621 chr7:2028884 MAD1L1 -0.43 -6.33 -0.33 7.92e-10 Lung cancer; CRC cis rs875971 1.000 rs709595 chr7:65817333 G/C cg12463550 chr7:65579703 CRCP 0.49 7.04 0.36 1.15e-11 Aortic root size; CRC cis rs7786808 0.741 rs11765319 chr7:158226790 A/G cg17401720 chr7:158221031 PTPRN2 0.46 7.75 0.39 1.14e-13 Obesity-related traits; CRC cis rs832540 0.931 rs2662040 chr5:56246610 A/G cg20203395 chr5:56204925 C5orf35 0.45 6.3 0.33 9.53e-10 Coronary artery disease; CRC trans rs9291683 0.679 rs2241483 chr4:10099831 A/G cg26043149 chr18:55253948 FECH -0.53 -8.39 -0.42 1.42e-15 Bone mineral density; CRC cis rs11690935 0.655 rs17614941 chr2:172541378 A/G cg13550731 chr2:172543902 DYNC1I2 0.64 9.07 0.45 1.07e-17 Schizophrenia; CRC cis rs1707322 0.752 rs6703748 chr1:46095976 G/A cg06784218 chr1:46089804 CCDC17 0.65 12.37 0.56 4.08e-29 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs970548 0.738 rs61854113 chr10:46004815 C/T cg15590007 chr10:45870220 ALOX5 0.57 5.8 0.3 1.53e-8 Total cholesterol levels;Cholesterol, total;HDL cholesterol;HDL cholesterol levels; CRC cis rs9322193 0.923 rs66516768 chr6:149993135 C/T cg00933542 chr6:150070202 PCMT1 0.31 6.34 0.33 7.37e-10 Lung cancer; CRC cis rs568617 0.903 rs601863 chr11:65646557 C/A cg19792802 chr11:65647270 CTSW -0.5 -7.55 -0.38 4.23e-13 Crohn's disease; CRC cis rs311392 0.554 rs689591 chr8:55096050 A/G cg06042504 chr8:55087323 NA -0.37 -5.77 -0.3 1.79e-8 Pelvic organ prolapse (moderate/severe); CRC cis rs13108904 0.901 rs4493484 chr4:1279944 G/A cg21620606 chr4:1342894 KIAA1530 0.36 5.89 0.31 9.62e-9 Obesity-related traits; CRC cis rs17767392 0.958 rs36093218 chr14:71872073 G/C cg13720639 chr14:72061746 SIPA1L1 -0.54 -6.89 -0.35 2.93e-11 Mitral valve prolapse; CRC cis rs9487051 0.698 rs4301336 chr6:109650140 A/T cg01475377 chr6:109611718 NA 0.36 5.65 0.3 3.56e-8 Reticulocyte fraction of red cells; CRC cis rs9611519 0.894 rs13053242 chr22:41459486 G/A cg03806693 chr22:41940476 POLR3H -0.58 -7.36 -0.38 1.52e-12 Neuroticism; CRC cis rs12477438 0.798 rs12468419 chr2:99579680 G/A cg14399236 chr2:99771627 LIPT1;TSGA10 -0.61 -8.36 -0.42 1.85e-15 Chronic sinus infection; CRC cis rs2455601 0.744 rs11042133 chr11:8966511 A/C cg21881798 chr11:8931708 C11orf17;ST5 -0.57 -6.57 -0.34 1.95e-10 Schizophrenia; CRC cis rs2991971 0.934 rs7903 chr1:45976472 G/C cg24296786 chr1:45957014 TESK2 0.56 8.5 0.42 6.77e-16 High light scatter reticulocyte count; CRC cis rs9326248 0.954 rs4938349 chr11:117021923 C/T cg10130564 chr11:117069849 TAGLN 0.36 6.78 0.35 5.59e-11 Blood protein levels; CRC trans rs12478296 1.000 rs6743297 chr2:243013814 A/G cg18288967 chr1:45987694 PRDX1 0.63 7.1 0.36 7.74e-12 Obesity-related traits; CRC cis rs1046896 0.552 rs12602280 chr17:80805421 G/C cg08200770 chr17:80723486 TBCD -0.49 -7.4 -0.38 1.12e-12 Glycated hemoglobin levels; CRC cis rs6500395 0.962 rs1039341 chr16:48574869 C/T cg04672837 chr16:48644449 N4BP1 0.42 6.04 0.32 4.07e-9 Response to tocilizumab in rheumatoid arthritis; CRC cis rs9457247 0.967 rs2149092 chr6:167372978 C/T cg23791538 chr6:167370224 RNASET2 0.39 6.1 0.32 2.93e-9 Crohn's disease; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg01646575 chr2:128785020 SAP130 0.45 6.35 0.33 7.26e-10 Intelligence (multi-trait analysis); CRC cis rs2243480 1.000 rs1039664 chr7:65449716 T/G cg18252515 chr7:66147081 NA -1.04 -12.03 -0.55 7.26e-28 Diabetic kidney disease; CRC cis rs6570726 0.791 rs440477 chr6:145854188 C/T cg13319975 chr6:146136371 FBXO30 -0.45 -6.78 -0.35 5.5e-11 Lobe attachment (rater-scored or self-reported); CRC cis rs9443645 0.901 rs9341754 chr6:79584973 A/C cg11833968 chr6:79620685 NA -0.37 -6.47 -0.34 3.53e-10 Intelligence (multi-trait analysis); CRC cis rs6546324 0.625 rs2902008 chr2:67802950 T/C cg15745817 chr2:67799979 NA -0.55 -9.09 -0.45 9.8e-18 Endometriosis; CRC cis rs2243480 1.000 rs437889 chr7:65509234 G/A cg25985355 chr7:65971099 NA -0.54 -6.05 -0.32 3.94e-9 Diabetic kidney disease; CRC cis rs4664293 0.867 rs2059698 chr2:160642416 C/T cg08347373 chr2:160653686 CD302 0.5 7.69 0.39 1.73e-13 Monocyte percentage of white cells; CRC cis rs2243480 1.000 rs410128 chr7:65603173 C/T cg25985355 chr7:65971099 NA -0.53 -5.85 -0.31 1.17e-8 Diabetic kidney disease; CRC cis rs995000 0.931 rs4329540 chr1:63027024 C/T cg19896129 chr1:63156450 NA -0.44 -6.75 -0.35 6.74e-11 Triglyceride levels; CRC cis rs6546324 0.580 rs2861684 chr2:67837380 T/C cg15745817 chr2:67799979 NA -0.44 -7.81 -0.4 7.73e-14 Endometriosis; CRC cis rs265548 0.646 rs36692 chr19:17906839 C/T cg16744531 chr19:17905626 B3GNT3 0.61 10.26 0.49 1.32e-21 Tumor biomarkers; CRC cis rs2762353 0.595 rs10498728 chr6:25751320 A/T cg03517284 chr6:25882590 NA -0.77 -11.07 -0.52 1.98e-24 Blood metabolite levels; CRC cis rs6951245 1.000 rs6951245 chr7:1058193 G/A cg18402987 chr7:1209562 NA 0.59 6.26 0.33 1.22e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs3820068 0.581 rs61056912 chr1:15926296 A/G cg13390004 chr1:15929781 NA 0.49 7.05 0.36 1.03e-11 Systolic blood pressure; CRC cis rs7147624 0.938 rs10467734 chr14:65913947 C/T cg03016385 chr14:66212404 NA -1.06 -10.93 -0.52 6.34e-24 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs10911363 0.549 rs12742245 chr1:183446922 T/A cg09173681 chr1:183549694 NCF2 0.76 10.42 0.5 3.71e-22 Systemic lupus erythematosus; CRC cis rs597539 0.580 rs7935851 chr11:68731122 A/G cg04772025 chr11:68637568 NA 0.43 6.54 0.34 2.33e-10 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs9322193 0.962 rs10872653 chr6:150100043 A/C cg13206674 chr6:150067644 NUP43 0.57 8.14 0.41 8.29e-15 Lung cancer; CRC cis rs6499244 0.526 rs7193221 chr16:69848721 C/G cg00738113 chr16:70207722 CLEC18C -0.33 -5.64 -0.3 3.75e-8 Menarche (age at onset); CRC cis rs881375 0.692 rs2072438 chr9:123651301 T/C cg09419670 chr9:123605666 PSMD5;LOC253039 0.51 8.14 0.41 8.05e-15 Rheumatoid arthritis; CRC cis rs9611565 0.765 rs132908 chr22:41801795 G/A cg03806693 chr22:41940476 POLR3H 1.04 12.91 0.58 3.83e-31 Vitiligo; CRC cis rs9926296 0.585 rs4785595 chr16:89835521 C/T cg03388025 chr16:89894329 SPIRE2 -0.48 -9.88 -0.48 2.44e-20 Vitiligo; CRC cis rs2985684 0.841 rs12894785 chr14:50049755 G/C cg04989706 chr14:50066350 PPIL5 -0.62 -8.55 -0.43 4.62e-16 Carotid intima media thickness; CRC cis rs910316 1.000 rs2098297 chr14:75619118 G/T cg08847533 chr14:75593920 NEK9 -0.93 -18.42 -0.71 1.5e-52 Height; CRC cis rs7613875 0.620 rs17657688 chr3:50033228 C/T cg05623727 chr3:50126028 RBM5 -0.58 -10.16 -0.49 2.82e-21 Body mass index; CRC cis rs11123170 0.650 rs2289897 chr2:113977454 G/A cg21550016 chr2:113992930 PAX8;LOC440839;LOC654433 0.62 7.52 0.38 5.38e-13 Renal function-related traits (BUN); CRC cis rs7617773 0.539 rs13082217 chr3:48383264 T/C cg11946769 chr3:48343235 NME6 0.6 8.14 0.41 8.14e-15 Coronary artery disease; CRC cis rs561341 1.000 rs2470267 chr17:30274132 G/A cg12193833 chr17:30244370 NA -0.61 -7.78 -0.39 9.61e-14 Hip circumference adjusted for BMI; CRC cis rs6952808 0.756 rs12537348 chr7:1948172 C/G cg00106254 chr7:1943704 MAD1L1 -0.51 -7.47 -0.38 7.36e-13 Bipolar disorder and schizophrenia; CRC cis rs10865541 0.902 rs7593978 chr2:3415544 C/T cg22182287 chr2:3452347 TTC15 0.37 5.79 0.3 1.65e-8 Obesity-related traits; CRC cis rs910316 0.737 rs175080 chr14:75513828 G/A cg03030879 chr14:75389066 RPS6KL1 0.4 6.1 0.32 2.98e-9 Height; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg17524854 chr12:67663046 CAND1 0.48 6.27 0.33 1.1e-9 Thyroid stimulating hormone; CRC cis rs883565 0.568 rs4616582 chr3:39028854 G/T cg01426195 chr3:39028469 NA 0.53 8.52 0.43 5.87e-16 Handedness; CRC cis rs1801251 1.000 rs283486 chr2:233644223 A/G cg25237894 chr2:233734115 C2orf82 0.55 8.96 0.44 2.51e-17 Coronary artery disease; CRC cis rs7843479 0.601 rs727693 chr8:21850116 A/G cg17168535 chr8:21777572 XPO7 0.61 10.31 0.49 8.58e-22 Mean corpuscular volume; CRC cis rs2032447 0.670 rs198815 chr6:26127271 A/G cg03264133 chr6:25882463 NA 0.43 5.84 0.31 1.24e-8 Intelligence (multi-trait analysis); CRC cis rs7618915 1.000 rs3852063 chr3:52349204 A/G cg15147215 chr3:52552868 STAB1 -0.52 -7.5 -0.38 6.14e-13 Bipolar disorder; CRC cis rs9896933 0.830 rs607544 chr17:80768760 C/G cg02398342 chr17:80708632 TBCD;FN3K 0.55 6.77 0.35 5.99e-11 Bone mineral accretion in asthma (oral corticosteroid dose interaction); CRC cis rs6693567 0.565 rs7544900 chr1:150262333 A/C cg15654264 chr1:150340011 RPRD2 -0.38 -5.76 -0.3 1.98e-8 Migraine; CRC cis rs2204008 0.774 rs11495721 chr12:38337224 A/C cg26384229 chr12:38710491 ALG10B 0.67 9.53 0.47 3.55e-19 Bladder cancer; CRC cis rs7274811 0.744 rs2071054 chr20:32265839 A/G cg14921437 chr20:32255988 NECAB3;C20orf134 -0.42 -5.77 -0.3 1.79e-8 Height; CRC cis rs4731207 0.596 rs13240512 chr7:124571890 G/A cg23710748 chr7:124431027 NA -0.4 -6.25 -0.33 1.29e-9 Cutaneous malignant melanoma; CRC cis rs10991814 1.000 rs59581968 chr9:93943140 C/T cg14446406 chr9:93919335 NA 0.59 7.26 0.37 2.8e-12 Neutrophil percentage of granulocytes; CRC cis rs875971 0.862 rs4718330 chr7:65715243 G/A cg12463550 chr7:65579703 CRCP -0.53 -7.42 -0.38 1.04e-12 Aortic root size; CRC cis rs7618915 0.547 rs2118540 chr3:52629386 T/C cg18404041 chr3:52824283 ITIH1 -0.44 -8.95 -0.44 2.69e-17 Bipolar disorder; CRC cis rs2717559 0.522 rs10956987 chr8:143886613 T/C cg05569086 chr8:143859399 LYNX1 -0.65 -11.62 -0.54 2.18e-26 Urinary tract infection frequency; CRC cis rs6685188 0.920 rs10751444 chr1:205662144 A/G cg11965913 chr1:205819406 PM20D1 -0.45 -6.45 -0.34 3.99e-10 White blood cell count (basophil);Basophil percentage of white cells; CRC trans rs1656966 1.000 rs1656966 chr3:186466252 C/T cg25448636 chr17:17140084 FLCN 0.41 5.98 0.31 5.94e-9 Myopia (pathological); CRC cis rs2882667 0.898 rs10038121 chr5:138389602 A/G cg09476006 chr5:138032270 NA 0.43 7.26 0.37 2.89e-12 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs2739330 0.828 rs2330635 chr22:24251344 T/C cg18538332 chr22:24372958 LOC391322 -0.73 -11.29 -0.53 3.23e-25 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs6424115 0.708 rs12755062 chr1:24185025 T/A cg15997130 chr1:24165203 NA -0.6 -7.73 -0.39 1.34e-13 Immature fraction of reticulocytes; CRC cis rs10991814 0.920 rs7043552 chr9:94025991 G/A cg14446406 chr9:93919335 NA 0.58 6.41 0.33 5.03e-10 Neutrophil percentage of granulocytes; CRC cis rs2933343 0.951 rs789251 chr3:128576770 G/A cg11901034 chr3:128598214 ACAD9 -0.5 -6.08 -0.32 3.24e-9 IgG glycosylation; CRC cis rs11212617 0.905 rs3901851 chr11:108352335 G/A cg14761454 chr11:108092087 ATM;NPAT 0.39 5.77 0.3 1.87e-8 Response to metformin in type 2 diabetes (glycemic); CRC cis rs72615157 0.645 rs76281814 chr7:99846414 T/C cg07160278 chr7:100027354 MEPCE;ZCWPW1 0.77 8.75 0.43 1.16e-16 Lung function (FEV1/FVC); CRC cis rs2230307 0.536 rs7530361 chr1:100462860 T/C cg24955406 chr1:100503596 HIAT1 0.51 6.14 0.32 2.31e-9 Carotid intima media thickness; CRC cis rs524281 0.773 rs10791862 chr11:66013664 T/C cg14036092 chr11:66035641 RAB1B -0.56 -6.35 -0.33 7.22e-10 Electroencephalogram traits; CRC cis rs2115630 0.905 rs1975277 chr15:85329558 C/T cg11189052 chr15:85197271 WDR73 -0.58 -9.46 -0.46 6.22e-19 P wave terminal force; CRC cis rs10504229 0.683 rs2873638 chr8:58114593 G/A cg04204079 chr8:58130323 NA -0.45 -5.84 -0.31 1.27e-8 Developmental language disorder (linguistic errors); CRC cis rs10744422 1.000 rs897386 chr12:123341289 A/C cg25930673 chr12:123319894 HIP1R -0.55 -5.92 -0.31 8.21e-9 Schizophrenia; CRC trans rs10504229 1.000 rs67105789 chr8:58192002 G/T cg04077850 chr5:125800366 GRAMD3 0.37 6.27 0.33 1.15e-9 Developmental language disorder (linguistic errors); CRC cis rs34172651 0.517 rs3803716 chr16:24802325 C/T cg06028605 chr16:24865363 SLC5A11 0.59 9.67 0.47 1.29e-19 Intelligence (multi-trait analysis); CRC cis rs769267 0.965 rs4808938 chr19:19401218 G/A cg01262667 chr19:19385393 TM6SF2 0.37 6.17 0.32 2.05e-9 Tonsillectomy; CRC trans rs5756813 0.754 rs11705616 chr22:38180487 G/T cg19894588 chr14:64061835 NA -0.55 -7.53 -0.38 4.93e-13 Optic cup area;Vertical cup-disc ratio; CRC cis rs7927771 0.965 rs12364432 chr11:47902883 G/A cg20307385 chr11:47447363 PSMC3 -0.48 -6.38 -0.33 5.86e-10 Subjective well-being; CRC cis rs561341 1.000 rs55959993 chr17:30254771 C/G cg19193384 chr17:30244184 NA -0.63 -7.17 -0.37 5.09e-12 Hip circumference adjusted for BMI; CRC cis rs6912958 0.684 rs2787893 chr6:88387359 C/G cg08069147 chr6:88032118 GJB7;C6orf162 -0.54 -7.91 -0.4 3.86e-14 Monocyte percentage of white cells; CRC cis rs12431939 0.947 rs56156789 chr14:51633899 C/G cg23942311 chr14:51606299 NA -0.56 -6.24 -0.33 1.32e-9 Cancer; CRC cis rs4665809 0.590 rs7260 chr2:26413917 C/T cg22920501 chr2:26401640 FAM59B -0.78 -11.31 -0.53 2.93e-25 Gut microbiome composition (summer); CRC cis rs4713118 0.527 rs36042294 chr6:27720712 C/G cg12273811 chr6:28175739 NA 0.45 6.51 0.34 2.86e-10 Parkinson's disease; CRC cis rs2230307 0.536 rs554742 chr1:100512568 G/A cg24955406 chr1:100503596 HIAT1 0.56 6.38 0.33 6.03e-10 Carotid intima media thickness; CRC cis rs6429082 0.608 rs4469707 chr1:235570634 T/C cg26050004 chr1:235667680 B3GALNT2 -0.44 -5.83 -0.31 1.33e-8 Adiposity; CRC cis rs440932 0.717 rs330944 chr8:9021293 C/T cg20400248 chr8:9005257 PPP1R3B 0.39 5.83 0.31 1.36e-8 High light scatter reticulocyte percentage of red cells; CRC cis rs7727544 0.669 rs113823725 chr5:131563501 C/G cg09877947 chr5:131593287 PDLIM4 0.36 6.44 0.33 4.18e-10 Blood metabolite levels; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg06700871 chr2:84686330 SUCLG1 0.4 6.02 0.31 4.72e-9 Liver disease severity in Alagille syndrome; CRC cis rs959260 0.588 rs7219 chr17:73315368 A/G cg14668889 chr17:73230827 NUP85 0.5 7.31 0.37 2.1e-12 Systemic lupus erythematosus; CRC cis rs12144094 0.882 rs10218713 chr1:120247899 A/G cg20995928 chr1:120229863 NA 0.47 6.77 0.35 5.98e-11 Height; CRC cis rs72781680 0.611 rs36052574 chr2:24306587 A/C cg06627628 chr2:24431161 ITSN2 -0.52 -5.92 -0.31 8.28e-9 Lymphocyte counts; CRC cis rs13315871 0.929 rs9818581 chr3:58293101 A/G cg20936604 chr3:58311152 NA -0.74 -6.94 -0.36 2.05e-11 Cholesterol, total; CRC cis rs7786808 0.608 rs9692003 chr7:158204696 G/A cg09998033 chr7:158218633 PTPRN2 0.5 7.0 0.36 1.49e-11 Obesity-related traits; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg01220033 chr9:131419100 WDR34 0.46 6.23 0.32 1.47e-9 Response to antipsychotic treatment; CRC cis rs763121 0.925 rs17032 chr22:39130843 C/G cg06022373 chr22:39101656 GTPBP1 0.75 12.12 0.56 3.38e-28 Menopause (age at onset); CRC cis rs9868809 0.505 rs35064573 chr3:48740280 C/A cg00383909 chr3:49044727 WDR6 0.79 8.04 0.41 1.68e-14 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; CRC cis rs919433 1.000 rs1560277 chr2:198187903 C/T cg03934865 chr2:198174659 NA 0.35 5.63 0.3 3.9e-8 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC cis rs7705042 0.865 rs2338822 chr5:141503059 T/C cg07392085 chr5:141489673 NDFIP1 0.45 7.15 0.37 5.54e-12 Asthma; CRC cis rs870825 0.929 rs10015218 chr4:185589789 T/C cg04058563 chr4:185651563 MLF1IP 0.56 5.92 0.31 8.04e-9 Blood protein levels; CRC cis rs9611565 0.918 rs7290404 chr22:41749796 C/T cg06634786 chr22:41940651 POLR3H -0.62 -7.27 -0.37 2.62e-12 Vitiligo; CRC cis rs10504229 0.728 rs72650861 chr8:58153273 T/C cg21724239 chr8:58056113 NA 0.62 8.38 0.42 1.51e-15 Developmental language disorder (linguistic errors); CRC cis rs73206853 0.841 rs73191815 chr12:110914698 G/A cg12870014 chr12:110450643 ANKRD13A 0.77 7.35 0.38 1.59e-12 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC cis rs921968 1.000 rs921968 chr2:219272294 G/T cg02176678 chr2:219576539 TTLL4 0.42 6.66 0.34 1.18e-10 Mean corpuscular hemoglobin concentration; CRC cis rs1005277 0.505 rs200910 chr10:38108176 C/T cg25517755 chr10:38738941 LOC399744 -0.44 -6.43 -0.33 4.6e-10 Extrinsic epigenetic age acceleration; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg18373552 chr10:76871314 SAMD8 0.47 6.56 0.34 2.03e-10 Anxiety disorder; CRC cis rs9916302 0.706 rs1054488 chr17:37687968 A/G cg00129232 chr17:37814104 STARD3 -0.58 -7.27 -0.37 2.6e-12 Glomerular filtration rate (creatinine); CRC cis rs7618915 0.547 rs34017441 chr3:52742413 T/C cg18099408 chr3:52552593 STAB1 -0.45 -7.32 -0.37 1.91e-12 Bipolar disorder; CRC cis rs10782582 0.586 rs11161902 chr1:76392498 C/G cg10523679 chr1:76189770 ACADM -0.42 -5.92 -0.31 8.22e-9 Daytime sleep phenotypes; CRC cis rs1577917 0.771 rs4419647 chr6:86225739 T/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A 0.66 8.73 0.43 1.35e-16 Response to antipsychotic treatment; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg12058391 chr8:63951472 GGH 0.43 6.03 0.32 4.29e-9 Anxiety disorder; CRC cis rs10504229 0.595 rs79077737 chr8:58117520 G/A cg05313129 chr8:58192883 C8orf71 -0.43 -5.96 -0.31 6.54e-9 Developmental language disorder (linguistic errors); CRC cis rs4731207 0.561 rs12706631 chr7:124586580 G/A cg23710748 chr7:124431027 NA -0.38 -6.08 -0.32 3.35e-9 Cutaneous malignant melanoma; CRC cis rs11148252 0.755 rs116860555 chr13:52936937 C/T cg12458913 chr13:53173898 NA -0.53 -8.4 -0.42 1.33e-15 Lewy body disease; CRC cis rs17826219 0.500 rs2874724 chr17:29072433 T/C cg01831904 chr17:28903510 LRRC37B2 -0.62 -6.39 -0.33 5.8e-10 Body mass index; CRC cis rs4665809 1.000 rs6546726 chr2:26275116 A/G cg27170947 chr2:26402098 FAM59B -0.44 -5.91 -0.31 8.44e-9 Gut microbiome composition (summer); CRC trans rs1814175 0.765 rs1794141 chr11:49914135 G/C cg15704280 chr7:45808275 SEPT13 -1.02 -20.57 -0.75 5.09e-61 Height; CRC cis rs4727027 0.933 rs1058059 chr7:148879134 A/T cg12479418 chr7:148823350 ZNF425;ZNF398 0.44 5.92 0.31 8.13e-9 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC trans rs10982213 0.830 rs2274163 chr9:117188714 C/T cg13260133 chr10:104626808 NA 0.4 6.16 0.32 2.07e-9 Interleukin-6 levels; CRC cis rs2845885 0.793 rs35927325 chr11:63882495 C/T cg24431193 chr11:63883947 FLRT1;MACROD1 0.76 6.79 0.35 5.14e-11 Body mass index; CRC cis rs6693567 0.565 rs12093148 chr1:150265173 G/A cg04165759 chr1:150448943 RPRD2 -0.36 -5.96 -0.31 6.48e-9 Migraine; CRC cis rs17767392 0.834 rs72728406 chr14:71734992 G/A cg13720639 chr14:72061746 SIPA1L1 -0.53 -6.42 -0.33 4.67e-10 Mitral valve prolapse; CRC cis rs9534288 0.797 rs1326401 chr13:46571602 A/G cg15192986 chr13:46630673 CPB2 0.67 9.29 0.46 2.22e-18 Blood protein levels; CRC cis rs7589728 1.000 rs7425670 chr2:88522028 C/T cg04511125 chr2:88470314 THNSL2 0.66 6.86 0.35 3.41e-11 Plasma clusterin levels; CRC cis rs11690935 0.632 rs12991740 chr2:172885996 C/T cg13550731 chr2:172543902 DYNC1I2 0.66 9.72 0.47 8.41e-20 Schizophrenia; CRC cis rs2239547 0.618 rs1573815 chr3:52870132 A/G cg11645453 chr3:52864694 ITIH4 -0.61 -10.89 -0.51 8.61e-24 Schizophrenia; CRC cis rs7927592 0.913 rs3740631 chr11:68341722 T/G cg16797656 chr11:68205561 LRP5 0.36 5.73 0.3 2.27e-8 Total body bone mineral density; CRC trans rs2797160 1.000 rs2747720 chr6:126009458 A/G cg05039488 chr6:79577232 IRAK1BP1 0.49 7.29 0.37 2.25e-12 Endometrial cancer; CRC cis rs2228479 0.850 rs45567439 chr16:89814604 G/A cg19635926 chr16:89946313 TCF25 0.66 5.97 0.31 6.1e-9 Skin colour saturation; CRC cis rs282587 0.569 rs9604422 chr13:113410586 C/T cg04656015 chr13:113407548 ATP11A 0.61 7.48 0.38 6.63e-13 Glycated hemoglobin levels; CRC cis rs9326248 1.000 rs9326248 chr11:116999225 A/C cg26566898 chr11:117069891 TAGLN 0.41 8.43 0.42 1.1e-15 Blood protein levels; CRC cis rs938554 0.829 rs5028843 chr4:9940806 G/A cg00071950 chr4:10020882 SLC2A9 -0.41 -5.82 -0.31 1.43e-8 Blood metabolite levels; CRC cis rs4663866 0.901 rs3739066 chr2:239184124 G/T cg16914508 chr2:239161102 PER2 0.75 7.84 0.4 6.47e-14 Irritable bowel syndrome; CRC cis rs1707322 0.721 rs10749856 chr1:46164846 A/T cg06784218 chr1:46089804 CCDC17 0.66 12.38 0.56 3.81e-29 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs6570726 0.935 rs419847 chr6:145827278 A/G cg05347473 chr6:146136440 FBXO30 0.37 5.85 0.31 1.17e-8 Lobe attachment (rater-scored or self-reported); CRC cis rs9807989 0.507 rs13021177 chr2:103056493 A/G cg03938978 chr2:103052716 IL18RAP 0.58 10.12 0.49 3.95e-21 Asthma; CRC cis rs57994353 0.600 rs4400499 chr9:139305041 C/T cg14119001 chr9:139324193 INPP5E -0.44 -5.8 -0.3 1.6e-8 Eosinophil counts;Cutaneous squamous cell carcinoma; CRC trans rs12599106 0.792 rs12597352 chr16:34638507 A/T cg26668828 chr6:292823 DUSP22 -0.58 -8.66 -0.43 2.17e-16 Menopause (age at onset); CRC trans rs7647973 0.626 rs1586827 chr3:49671224 T/C cg21659725 chr3:3221576 CRBN -0.67 -7.46 -0.38 8.01e-13 Menarche (age at onset); CRC trans rs2727020 0.729 rs2299650 chr11:49174007 A/C cg15704280 chr7:45808275 SEPT13 -0.82 -14.08 -0.61 1.51e-35 Coronary artery disease; CRC cis rs250677 0.687 rs2963484 chr5:148451127 A/T cg23229984 chr5:148520753 ABLIM3 0.5 6.95 0.36 1.96e-11 Breast cancer; CRC cis rs72781680 0.752 rs55806536 chr2:23912697 A/G cg08917208 chr2:24149416 ATAD2B 0.98 9.11 0.45 8.06e-18 Lymphocyte counts; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg24775616 chr17:1157257 NA 0.39 6.2 0.32 1.7e-9 Liver disease severity in Alagille syndrome; CRC cis rs9926296 0.548 rs12447465 chr16:89829895 C/T cg04287289 chr16:89883240 FANCA 0.81 14.33 0.62 1.55e-36 Vitiligo; CRC cis rs7429990 0.901 rs7431567 chr3:48027832 G/T cg11946769 chr3:48343235 NME6 -0.5 -6.43 -0.33 4.61e-10 Educational attainment (years of education); CRC cis rs10504229 1.000 rs67344620 chr8:58187537 C/A cg02290350 chr8:58132656 NA -0.42 -5.96 -0.31 6.62e-9 Developmental language disorder (linguistic errors); CRC cis rs798554 0.836 rs798490 chr7:2801542 C/T cg17321639 chr7:2759063 NA -0.5 -6.52 -0.34 2.6200000000000003e-10 Height; CRC cis rs7605827 0.930 rs7568874 chr2:15546361 T/C cg19274914 chr2:15703543 NA 0.39 5.9 0.31 8.79e-9 Educational attainment (years of education); CRC cis rs727505 1.000 rs1541418 chr7:124448672 A/G cg23710748 chr7:124431027 NA -0.85 -14.98 -0.64 4.67e-39 Lewy body disease; CRC cis rs8141529 0.719 rs5762825 chr22:29223642 A/G cg02153584 chr22:29168773 CCDC117 0.52 7.74 0.39 1.21e-13 Lymphocyte counts; CRC cis rs1862618 0.802 rs33327 chr5:56142693 T/G cg12311346 chr5:56204834 C5orf35 -0.79 -10.4 -0.5 4.39e-22 Initial pursuit acceleration; CRC cis rs2576037 0.583 rs512699 chr18:44374681 C/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 -0.63 -10.69 -0.51 4.44e-23 Personality dimensions; CRC cis rs3768617 0.510 rs6424884 chr1:183065904 C/T ch.1.3577855R chr1:183094577 LAMC1 0.86 15.19 0.64 7.31e-40 Fuchs's corneal dystrophy; CRC cis rs12908161 0.920 rs35758837 chr15:85311382 C/T cg17507749 chr15:85114479 UBE2QP1 0.62 8.97 0.44 2.36e-17 Schizophrenia; CRC cis rs501120 0.564 rs2624681 chr10:44677301 G/C cg09554077 chr10:44749378 NA 0.5 6.98 0.36 1.62e-11 Coronary artery disease;Coronary heart disease; CRC cis rs561341 1.000 rs501312 chr17:30329066 A/G cg00745463 chr17:30367425 LRRC37B -0.88 -9.63 -0.47 1.7e-19 Hip circumference adjusted for BMI; CRC cis rs12681287 0.927 rs7003059 chr8:87330713 C/T cg27223183 chr8:87520930 FAM82B -0.42 -5.75 -0.3 1.99e-8 Caudate activity during reward; CRC cis rs9359856 0.956 rs9362664 chr6:90307703 G/A cg13799429 chr6:90582589 CASP8AP2 0.42 6.1 0.32 2.99e-9 Bipolar disorder; CRC cis rs1868673 1.000 rs1868672 chr3:150175231 T/C cg04908077 chr3:150187338 NA -0.33 -5.64 -0.3 3.62e-8 Waist circumference; CRC cis rs6860806 0.661 rs3763112 chr5:131586480 A/G cg04518342 chr5:131593106 PDLIM4 0.47 8.68 0.43 1.93e-16 Breast cancer; CRC cis rs9325144 0.505 rs826893 chr12:39100536 A/G cg13010199 chr12:38710504 ALG10B -0.39 -5.67 -0.3 3.14e-8 Morning vs. evening chronotype; CRC cis rs6951245 1.000 rs74785791 chr7:1088494 T/C cg04025307 chr7:1156635 C7orf50 0.64 6.66 0.34 1.16e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs847577 0.609 rs17435590 chr7:97784061 T/C cg00277769 chr7:97922759 BAIAP2L1 -0.4 -6.62 -0.34 1.42e-10 Breast cancer; CRC cis rs951366 0.789 rs823152 chr1:205736285 G/A cg07157834 chr1:205819609 PM20D1 0.82 12.72 0.57 2.06e-30 Menarche (age at onset); CRC cis rs5769765 0.908 rs9616216 chr22:50318927 T/C cg22709217 chr22:50311962 ALG12;CRELD2 -1.08 -16.03 -0.66 3.99e-43 Schizophrenia; CRC cis rs35883536 0.967 rs2050471 chr1:101175651 C/T cg14515779 chr1:101123966 NA -0.35 -6.36 -0.33 6.74e-10 Monocyte count; CRC cis rs3733585 0.673 rs7672947 chr4:9961368 G/C cg00071950 chr4:10020882 SLC2A9 -0.54 -9.54 -0.47 3.44e-19 Cleft plate (environmental tobacco smoke interaction); CRC cis rs7923609 0.967 rs2393977 chr10:65247609 A/C cg08743896 chr10:65200160 JMJD1C -0.42 -6.06 -0.32 3.73e-9 Educational attainment;Liver enzyme levels (alkaline phosphatase); CRC trans rs1493916 0.807 rs10775455 chr18:31310761 A/C cg27147174 chr7:100797783 AP1S1 -0.4 -7.09 -0.36 8.42e-12 Life satisfaction; CRC cis rs9814567 1.000 rs7374158 chr3:134270156 C/T cg06109529 chr3:134205091 CEP63;ANAPC13 -0.81 -12.19 -0.56 1.92e-28 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs1580019 0.844 rs1376290 chr7:32486922 C/T cg06627557 chr7:32535165 LSM5;AVL9 0.82 12.48 0.57 1.58e-29 Cognitive ability; CRC cis rs11212617 0.967 rs227067 chr11:108209360 A/G cg01991180 chr11:108092276 ATM;NPAT 0.4 5.75 0.3 2.06e-8 Response to metformin in type 2 diabetes (glycemic); CRC cis rs597539 0.652 rs686390 chr11:68656077 T/C cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.86 13.78 0.6 2.12e-34 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC trans rs11148252 0.904 rs3892337 chr13:53029485 C/G cg18335740 chr13:41363409 SLC25A15 0.61 9.62 0.47 1.85e-19 Lewy body disease; CRC cis rs394563 0.967 rs438852 chr6:149794533 C/T cg07828024 chr6:149772892 ZC3H12D 0.46 8.29 0.42 2.91e-15 Dupuytren's disease; CRC trans rs587242 0.956 rs12030748 chr1:96904404 G/A cg10631902 chr5:14652156 NA 0.44 6.84 0.35 3.84e-11 Body mass index (joint analysis main effects and physical activity interaction);Body mass index in physically inactive individuals;Body mass index; CRC cis rs10504229 1.000 rs17216648 chr8:58169429 C/T cg02290350 chr8:58132656 NA -0.43 -6.12 -0.32 2.64e-9 Developmental language disorder (linguistic errors); CRC cis rs9911578 1.000 rs7215808 chr17:56940742 G/C cg05425664 chr17:57184151 TRIM37 -0.49 -7.64 -0.39 2.32e-13 Intelligence (multi-trait analysis); CRC cis rs360798 0.532 rs1022110 chr2:63046039 T/G cg17519650 chr2:63277830 OTX1 -0.48 -6.64 -0.34 1.27e-10 Coronary artery disease; CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg01204964 chr21:35014044 ITSN1;CRYZL1 0.36 5.97 0.31 6.16e-9 Obesity-related traits; CRC cis rs4713118 0.513 rs149951 chr6:28033087 T/C cg25164649 chr6:28176230 NA 0.6 8.62 0.43 2.96e-16 Parkinson's disease; CRC cis rs1448094 0.512 rs7970842 chr12:86243258 C/T cg02569458 chr12:86230093 RASSF9 0.42 7.23 0.37 3.48e-12 Major depressive disorder; CRC cis rs2386661 0.547 rs72781996 chr10:5646485 C/G cg17085576 chr10:5658249 NA -0.44 -6.11 -0.32 2.87e-9 Breast cancer; CRC cis rs3857536 0.813 rs6455083 chr6:66935406 T/C cg07460842 chr6:66804631 NA -0.43 -5.81 -0.3 1.48e-8 Blood trace element (Cu levels); CRC cis rs3766606 0.505 rs67002863 chr1:7923478 G/A cg26816564 chr1:7831052 VAMP3 0.75 8.36 0.42 1.8e-15 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; CRC cis rs704795 0.867 rs7566052 chr2:27628635 A/G cg17158414 chr2:27665306 KRTCAP3 -0.29 -6.23 -0.32 1.45e-9 Menopause (age at onset); CRC cis rs59104589 0.521 rs62190404 chr2:242401422 C/T cg19488206 chr2:242435732 STK25 0.48 7.71 0.39 1.5e-13 Fibrinogen levels; CRC cis rs6543140 0.890 rs61122764 chr2:102999520 A/G cg03938978 chr2:103052716 IL18RAP 0.47 7.35 0.38 1.59e-12 Blood protein levels; CRC cis rs67311347 0.544 rs12633295 chr3:40335292 G/T cg09455208 chr3:40491958 NA -0.29 -5.81 -0.3 1.49e-8 Renal cell carcinoma; CRC cis rs2361710 0.611 rs12051781 chr17:78074468 A/G cg20811857 chr17:78079795 GAA -0.37 -5.67 -0.3 3.2e-8 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count;Immature fraction of reticulocytes; CRC cis rs826838 1.000 rs10880826 chr12:38672787 G/C cg13010199 chr12:38710504 ALG10B 0.46 6.09 0.32 3.08e-9 Heart rate; CRC cis rs870825 0.858 rs2014964 chr4:185588836 G/A cg04058563 chr4:185651563 MLF1IP 0.8 7.42 0.38 1e-12 Blood protein levels; CRC cis rs6546550 0.901 rs6546558 chr2:70145717 C/T cg02498382 chr2:70120550 SNRNP27 -0.55 -9.23 -0.45 3.45e-18 Prevalent atrial fibrillation; CRC cis rs950169 1.000 rs12915234 chr15:84758301 G/A cg11189052 chr15:85197271 WDR73 0.6 8.83 0.44 6.13e-17 Schizophrenia; CRC cis rs7666738 0.830 rs7664051 chr4:98766970 C/G cg17366294 chr4:99064904 C4orf37 0.42 6.89 0.36 2.81e-11 Colonoscopy-negative controls vs population controls; CRC cis rs79149102 0.579 rs12591994 chr15:75320306 A/G cg09165964 chr15:75287851 SCAMP5 -0.73 -5.64 -0.3 3.6e-8 Lung cancer; CRC cis rs11166629 1.000 rs6981735 chr8:135635730 T/C cg27224718 chr8:135614730 ZFAT 0.52 7.64 0.39 2.35e-13 Smoking quantity; CRC cis rs870825 0.616 rs4256263 chr4:185622959 C/A cg04058563 chr4:185651563 MLF1IP 0.72 9.38 0.46 1.12e-18 Blood protein levels; CRC cis rs2708977 1.000 rs13029764 chr2:97328874 C/T cg01950434 chr2:97203154 ARID5A -0.44 -6.68 -0.35 1.04e-10 Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes; CRC cis rs875971 1.000 rs11974219 chr7:65647410 C/T cg12463550 chr7:65579703 CRCP -0.49 -7.07 -0.36 9.56e-12 Aortic root size; CRC cis rs12142240 0.698 rs1057534 chr1:46815880 A/C cg14993813 chr1:46806288 NSUN4 -0.5 -6.4 -0.33 5.38e-10 Menopause (age at onset); CRC cis rs72781680 0.821 rs111571980 chr2:24201695 C/G cg08917208 chr2:24149416 ATAD2B 0.57 6.85 0.35 3.56e-11 Lymphocyte counts; CRC cis rs9487051 0.768 rs1269172 chr6:109522080 G/C cg21918786 chr6:109611834 NA -0.33 -5.63 -0.3 3.82e-8 Reticulocyte fraction of red cells; CRC trans rs17143387 0.803 rs78592156 chr10:8324943 T/C cg00390484 chr22:20019695 C22orf25;MIR185 0.49 5.99 0.31 5.39e-9 Scalp hair shape; CRC cis rs7762018 1.000 rs60253563 chr6:170083019 T/C cg24289452 chr6:170231220 NA -0.59 -6.42 -0.33 4.75e-10 Thiazide-induced adverse metabolic effects in hypertensive patients; CRC cis rs4713118 0.513 rs149955 chr6:28036225 G/C cg02683197 chr6:28174875 NA 0.62 8.4 0.42 1.31e-15 Parkinson's disease; CRC trans rs2303319 0.504 rs62188988 chr2:162531068 T/C cg11326919 chr17:43324904 LOC100133991 -0.64 -5.98 -0.31 5.7e-9 Cognitive function; CRC cis rs3806843 0.931 rs13168670 chr5:140146899 T/C cg19875535 chr5:140030758 IK 0.61 10.07 0.49 5.52e-21 Depressive symptoms (multi-trait analysis); CRC cis rs2836974 1.000 rs2836974 chr21:40663181 A/G cg11890956 chr21:40555474 PSMG1 -1.08 -18.17 -0.71 1.46e-51 Cognitive function; CRC cis rs7811142 1.000 rs6979335 chr7:100089860 T/C cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.56 6.95 0.36 2e-11 Platelet count; CRC cis rs9611565 0.512 rs8141103 chr22:42136930 T/C cg06481639 chr22:41940642 POLR3H 0.55 6.19 0.32 1.82e-9 Vitiligo; CRC cis rs35306767 0.903 rs12769873 chr10:936526 G/T cg26597838 chr10:835615 NA 0.94 11.35 0.53 2.08e-25 Eosinophil percentage of granulocytes; CRC cis rs7647973 0.626 rs11130217 chr3:49737323 A/G cg03060546 chr3:49711283 APEH 0.66 7.93 0.4 3.46e-14 Menarche (age at onset); CRC cis rs270601 0.710 rs371709 chr5:131583240 A/G cg22638593 chr5:131593259 PDLIM4 0.51 8.78 0.44 8.94e-17 Acylcarnitine levels; CRC cis rs270601 0.955 rs273911 chr5:131661526 C/G cg11843238 chr5:131593191 PDLIM4 0.43 7.36 0.38 1.52e-12 Acylcarnitine levels; CRC cis rs10242455 0.702 rs75156180 chr7:98964100 G/A cg18809830 chr7:99032528 PTCD1 -1.08 -7.75 -0.39 1.18e-13 Blood metabolite levels; CRC cis rs6840360 0.533 rs1397683 chr4:152715916 T/C cg09659197 chr4:152720779 NA -0.44 -8.63 -0.43 2.64e-16 Intelligence (multi-trait analysis); CRC cis rs7615952 0.599 rs6779141 chr3:125709995 A/T cg15145296 chr3:125709740 NA -0.59 -6.91 -0.36 2.47e-11 Blood pressure (smoking interaction); CRC cis rs1218582 0.772 rs4845400 chr1:154872523 C/T cg16680214 chr1:154839983 KCNN3 -0.46 -9.1 -0.45 8.99e-18 Prostate cancer; CRC cis rs12188164 0.965 rs11743639 chr5:450710 C/T cg16322479 chr5:444228 EXOC3;C5orf55 0.51 8.4 0.42 1.38e-15 Cystic fibrosis severity; CRC trans rs2303319 0.504 rs55925603 chr2:162497210 G/A cg27113153 chr11:123612418 ZNF202 -0.68 -6.06 -0.32 3.72e-9 Cognitive function; CRC cis rs4423214 0.840 rs1629220 chr11:71174553 C/T cg13043300 chr11:71146211 DHCR7 -0.44 -5.91 -0.31 8.58e-9 Vitamin D levels; CRC cis rs4713118 0.513 rs149945 chr6:28002853 T/C cg15786705 chr6:28176104 NA 0.61 8.9 0.44 3.91e-17 Parkinson's disease; CRC cis rs2304069 0.545 rs13168011 chr5:149392377 C/T cg22760475 chr5:149380129 HMGXB3;TIGD6 0.46 6.74 0.35 7.13e-11 HIV-1 control; CRC cis rs4757319 0.537 rs10832436 chr11:15430222 A/G cg03245590 chr11:15329459 NA 0.52 9.21 0.45 3.81e-18 Breast cancer; CRC cis rs4713118 0.869 rs9366700 chr6:27696951 C/T cg12273811 chr6:28175739 NA 0.53 7.64 0.39 2.4e-13 Parkinson's disease; CRC cis rs7707921 0.723 rs226197 chr5:81574925 G/A cg07807695 chr5:81608485 ATP6AP1L -0.49 -7.76 -0.39 1.07e-13 Breast cancer; CRC cis rs6758955 0.850 rs56261863 chr2:10480339 G/A cg15773312 chr2:10472214 HPCAL1 -0.82 -9.5 -0.46 4.43e-19 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; CRC cis rs754466 0.580 rs2289309 chr10:79571108 C/T cg17075019 chr10:79541650 NA -0.98 -19.23 -0.73 8.84e-56 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs17376456 0.825 rs7715562 chr5:93222034 C/T cg25358565 chr5:93447407 FAM172A -0.99 -9.66 -0.47 1.32e-19 Diabetic retinopathy; CRC cis rs6456156 0.586 rs6456149 chr6:167463902 T/C cg07741184 chr6:167504864 NA 0.39 6.9 0.36 2.63e-11 Primary biliary cholangitis; CRC cis rs8180040 0.701 rs62248439 chr3:46996448 A/G cg27129171 chr3:47204927 SETD2 -0.72 -11.39 -0.53 1.48e-25 Colorectal cancer; CRC cis rs7512552 0.839 rs11577843 chr1:150398258 A/G cg15654264 chr1:150340011 RPRD2 0.58 8.5 0.42 6.79e-16 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); CRC cis rs72781680 0.848 rs72798057 chr2:23976731 T/C cg08917208 chr2:24149416 ATAD2B 0.86 8.45 0.42 9.69e-16 Lymphocyte counts; CRC cis rs853679 0.546 rs200953 chr6:27837267 T/C cg15845792 chr6:28175446 NA 0.71 6.18 0.32 1.87e-9 Depression; CRC cis rs11583043 0.918 rs3850453 chr1:101408933 T/C cg00063077 chr1:101360652 SLC30A7;EXTL2 0.49 6.78 0.35 5.63e-11 Ulcerative colitis;Inflammatory bowel disease; CRC cis rs6961069 0.722 rs13438282 chr7:80262224 C/T cg04458919 chr7:80252533 CD36 0.35 6.15 0.32 2.22e-9 Platelet count; CRC cis rs3785574 0.886 rs62077504 chr17:61837734 A/G cg25654072 chr17:61904446 PSMC5;FTSJ3 0.43 5.94 0.31 7.24e-9 Height; CRC cis rs7772486 0.875 rs2814876 chr6:146304030 C/T cg23711669 chr6:146136114 FBXO30 0.67 11.4 0.53 1.37e-25 Lobe attachment (rater-scored or self-reported); CRC cis rs1862618 0.853 rs832578 chr5:56164223 C/T cg22800045 chr5:56110881 MAP3K1 0.59 6.4 0.33 5.22e-10 Initial pursuit acceleration; CRC cis rs1129187 0.755 rs9471982 chr6:42935998 G/A cg10862848 chr6:42927986 GNMT -0.39 -9.41 -0.46 8.54e-19 Alzheimer's disease in APOE e4+ carriers; CRC cis rs9902453 0.740 rs1382391 chr17:28111986 G/T cg26525008 chr17:28256777 EFCAB5;SSH2 -0.72 -12.06 -0.55 5.45e-28 Coffee consumption (cups per day); CRC cis rs7647973 0.516 rs12490393 chr3:49196132 C/T cg07690219 chr3:49449608 TCTA;RHOA -0.44 -5.61 -0.3 4.32e-8 Menarche (age at onset); CRC cis rs11971779 0.616 rs6949963 chr7:139054325 C/T cg07862535 chr7:139043722 LUC7L2 0.57 7.35 0.38 1.61e-12 Diisocyanate-induced asthma; CRC cis rs10982256 0.870 rs10982248 chr9:117250903 G/A cg13636371 chr9:117264095 DFNB31 0.33 6.41 0.33 5.17e-10 Bipolar disorder; CRC cis rs7945705 0.712 rs61876274 chr11:9019190 A/T cg12365402 chr11:9010492 NRIP3 0.55 9.91 0.48 2.03e-20 Hemoglobin concentration; CRC cis rs11958404 0.932 rs11950881 chr5:157410550 C/T cg05962755 chr5:157440814 NA 0.84 10.94 0.52 5.92e-24 IgG glycosylation; CRC cis rs11711311 1.000 rs2566963 chr3:113531849 G/A cg06805542 chr3:113465803 ATP6V1A;NAA50 0.53 7.38 0.38 1.28e-12 IgG glycosylation; CRC cis rs1862618 0.525 rs2662019 chr5:56263104 A/G cg20203395 chr5:56204925 C5orf35 0.56 6.84 0.35 3.89e-11 Initial pursuit acceleration; CRC trans rs6544773 0.668 rs341603 chr2:45065376 A/G cg10208897 chr5:178548229 ADAMTS2 0.36 6.14 0.32 2.32e-9 Mosquito bite size; CRC cis rs3806843 0.546 rs246023 chr5:140333990 G/T cg19875535 chr5:140030758 IK 0.4 6.12 0.32 2.64e-9 Depressive symptoms (multi-trait analysis); CRC trans rs7267979 0.903 rs6132819 chr20:25218618 C/G cg17903999 chr18:56338584 MALT1 -0.41 -6.39 -0.33 5.72e-10 Liver enzyme levels (alkaline phosphatase); CRC cis rs709400 1.000 rs61995780 chr14:104120612 A/G cg24130564 chr14:104152367 KLC1 -0.45 -6.68 -0.35 1.02e-10 Body mass index; CRC cis rs6951245 0.554 rs78999139 chr7:1138525 G/A cg18402987 chr7:1209562 NA 0.52 6.3 0.33 9.68e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs7264396 0.635 rs6058378 chr20:34546658 G/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.61 -9.82 -0.48 4.01e-20 Total cholesterol levels; CRC cis rs8177179 0.967 rs9820225 chr3:133449189 A/G cg24879335 chr3:133465180 TF 0.49 9.67 0.47 1.26e-19 Iron status biomarkers (transferrin levels); CRC cis rs1865760 0.566 rs2032445 chr6:26044812 T/A cg16482183 chr6:26056742 HIST1H1C 0.52 7.56 0.38 4.08e-13 Height; CRC cis rs7193541 0.684 rs7191665 chr16:74688948 T/G cg01733217 chr16:74700730 RFWD3 1.05 22.23 0.77 1.67e-67 Multiple myeloma; CRC cis rs1728785 0.892 rs4783562 chr16:68562963 A/G cg02972257 chr16:68554789 NA -0.63 -7.21 -0.37 3.91e-12 Ulcerative colitis; CRC cis rs861020 0.883 rs680331 chr1:209959872 G/A cg09163369 chr1:210001066 C1orf107 0.51 6.67 0.35 1.05e-10 Orofacial clefts; CRC trans rs9858542 0.953 rs11719996 chr3:49525958 T/C cg21582582 chr3:182698605 DCUN1D1 -0.51 -6.47 -0.34 3.47e-10 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs2880765 0.835 rs7164106 chr15:86032590 T/C cg17133734 chr15:86042851 AKAP13 0.43 6.73 0.35 7.69e-11 Coronary artery disease; CRC cis rs875971 0.522 rs56028712 chr7:65466565 C/T cg11764359 chr7:65958608 NA 0.51 7.66 0.39 2.07e-13 Aortic root size; CRC cis rs2153535 0.580 rs9406161 chr6:8466144 G/T cg07606381 chr6:8435919 SLC35B3 0.68 10.9 0.51 8.26e-24 Motion sickness; CRC cis rs11098499 0.954 rs71629403 chr4:120372567 C/T cg09307838 chr4:120376055 NA 0.72 11.07 0.52 2.07e-24 Corneal astigmatism; CRC cis rs9488822 0.676 rs13194714 chr6:116394819 T/A cg18764771 chr6:116381957 FRK 0.25 7.19 0.37 4.45e-12 Cholesterol, total;LDL cholesterol; CRC cis rs769267 1.000 rs7247309 chr19:19439631 A/T cg03709012 chr19:19516395 GATAD2A -0.68 -10.4 -0.5 4.29e-22 Tonsillectomy; CRC cis rs7224685 0.501 rs4790559 chr17:4010478 G/T cg05562828 chr17:3906858 NA -0.66 -11.48 -0.53 7.1e-26 Type 2 diabetes; CRC cis rs4689592 0.503 rs66885632 chr4:7053738 T/C cg06697600 chr4:7070879 GRPEL1 0.5 6.29 0.33 9.84e-10 Monocyte percentage of white cells; CRC cis rs11997175 0.546 rs10808337 chr8:33583850 T/C ch.8.33884649F chr8:33765107 NA 0.43 6.67 0.35 1.06e-10 Body mass index; CRC cis rs60871478 1.000 rs62432250 chr7:801792 C/G cg04727924 chr7:799746 HEATR2 -0.44 -6.45 -0.34 3.94e-10 Cerebrospinal P-tau181p levels; CRC cis rs12477438 0.765 rs10181422 chr2:99558970 A/G cg14399236 chr2:99771627 LIPT1;TSGA10 -0.59 -8.12 -0.41 9.74e-15 Chronic sinus infection; CRC cis rs7487075 0.619 rs4768724 chr12:46848416 C/T cg22049899 chr12:47219821 SLC38A4 0.32 5.86 0.31 1.12e-8 Itch intensity from mosquito bite; CRC cis rs7659604 0.539 rs7660548 chr4:122730821 G/C cg20573242 chr4:122745356 CCNA2 0.57 8.32 0.42 2.37e-15 Type 2 diabetes; CRC trans rs6860806 0.507 rs169256 chr5:131688533 A/G cg08235057 chr22:21057110 TMEM191A 0.51 6.12 0.32 2.59e-9 Breast cancer; CRC cis rs910316 0.967 rs4903292 chr14:75656245 A/G cg11812906 chr14:75593930 NEK9 0.53 8.1 0.41 1.09e-14 Height; CRC cis rs8072100 0.701 rs10163469 chr17:45687767 G/A cg25173405 chr17:45401733 C17orf57 0.42 6.49 0.34 3.07e-10 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC trans rs7819412 0.807 rs4840542 chr8:10944809 G/T cg06636001 chr8:8085503 FLJ10661 -0.62 -9.49 -0.46 4.79e-19 Triglycerides; CRC cis rs1129187 0.818 rs9462858 chr6:42946490 C/A cg03790207 chr6:42947109 PEX6 -0.44 -6.1 -0.32 3e-9 Alzheimer's disease in APOE e4+ carriers; CRC cis rs6502050 0.835 rs7501527 chr17:80099355 A/C cg22110888 chr17:80059540 CCDC57 0.42 6.59 0.34 1.71e-10 Life satisfaction; CRC cis rs10504229 0.683 rs72649192 chr8:58110490 T/C cg11062466 chr8:58055876 NA 0.53 6.75 0.35 6.69e-11 Developmental language disorder (linguistic errors); CRC cis rs10876993 0.928 rs10877008 chr12:58103592 A/G cg15848620 chr12:58087721 OS9 -0.59 -8.04 -0.41 1.66e-14 Celiac disease or Rheumatoid arthritis; CRC cis rs6860806 0.507 rs2631369 chr5:131705266 G/C cg12564285 chr5:131593104 PDLIM4 -0.47 -8.04 -0.41 1.62e-14 Breast cancer; CRC trans rs2303319 0.504 rs12467613 chr2:162603216 G/T cg03774468 chr3:140950104 ACPL2 -0.65 -6.07 -0.32 3.61e-9 Cognitive function; CRC cis rs6951245 0.572 rs79489623 chr7:1045632 C/T cg26224354 chr7:1096374 C7orf50;GPR146 -0.97 -8.25 -0.41 3.81e-15 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs611744 0.647 rs1609472 chr8:109269232 T/G cg18478394 chr8:109455254 TTC35 0.39 6.0 0.31 5.12e-9 Dupuytren's disease; CRC cis rs13191362 1.000 rs13209100 chr6:163159350 C/T cg21926612 chr6:163149169 PACRG;PARK2 0.78 11.62 0.54 2.26e-26 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs17270561 0.779 rs12209218 chr6:25887776 C/A cg16482183 chr6:26056742 HIST1H1C 0.87 11.32 0.53 2.58e-25 Iron status biomarkers; CRC cis rs62408225 1.000 rs2875584 chr6:90950628 C/T cg06866423 chr6:90926672 BACH2 0.49 8.08 0.41 1.26e-14 Eosinophil counts;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC cis rs6681460 0.549 rs7547857 chr1:67031890 A/G cg02459107 chr1:67143332 SGIP1 0.34 5.63 0.3 3.78e-8 Presence of antiphospholipid antibodies; CRC cis rs72781680 0.611 rs55983206 chr2:24333995 A/C cg20701182 chr2:24300061 SF3B14 0.66 7.86 0.4 5.62e-14 Lymphocyte counts; CRC cis rs7264396 0.747 rs73283043 chr20:34383863 G/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.6 -10.47 -0.5 2.42e-22 Total cholesterol levels; CRC cis rs798554 0.757 rs1182171 chr7:2878510 A/G cg19346786 chr7:2764209 NA -0.4 -6.95 -0.36 1.96e-11 Height; CRC cis rs10504229 0.906 rs113823909 chr8:58170635 A/G cg01721255 chr8:58191610 C8orf71 0.51 6.33 0.33 7.92e-10 Developmental language disorder (linguistic errors); CRC cis rs4700695 0.719 rs27087 chr5:65453050 G/A cg21114390 chr5:65439923 SFRS12 -0.65 -8.64 -0.43 2.48e-16 Facial morphology (factor 19); CRC cis rs34779708 0.966 rs57081218 chr10:35434608 A/G cg03585969 chr10:35415529 CREM 0.56 7.53 0.38 4.85e-13 Inflammatory bowel disease;Crohn's disease; CRC cis rs951366 0.528 rs1172198 chr1:205662718 C/T cg24503407 chr1:205819492 PM20D1 0.73 10.45 0.5 2.97e-22 Menarche (age at onset); CRC cis rs875971 0.597 rs11763224 chr7:65983615 G/T cg18876405 chr7:65276391 NA 0.45 6.19 0.32 1.83e-9 Aortic root size; CRC cis rs62064224 0.714 rs62064225 chr17:30635429 C/T cg25809561 chr17:30822961 MYO1D 0.52 9.43 0.46 7.81e-19 Schizophrenia; CRC cis rs4926298 1.000 rs4926298 chr19:13153035 C/T cg11738485 chr19:12877000 HOOK2 -0.44 -5.93 -0.31 7.86e-9 Bipolar disorder; CRC cis rs4478858 0.647 rs6425720 chr1:31709555 A/G cg00250761 chr1:31883323 NA -0.44 -8.45 -0.42 9.65e-16 Alcohol dependence; CRC trans rs9858542 0.953 rs11711485 chr3:49491983 G/T cg21582582 chr3:182698605 DCUN1D1 -0.5 -6.18 -0.32 1.89e-9 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs11628318 0.660 rs8009475 chr14:103058608 A/G cg23461800 chr14:103021989 NA -0.68 -7.82 -0.4 7.46e-14 Platelet count; CRC cis rs62432291 0.681 rs433786 chr6:159665946 T/A cg14500486 chr6:159655392 FNDC1 -0.76 -9.16 -0.45 5.51e-18 Joint mobility (Beighton score); CRC cis rs9911578 0.967 rs57869245 chr17:57106630 A/G cg05425664 chr17:57184151 TRIM37 0.47 7.57 0.39 3.81e-13 Intelligence (multi-trait analysis); CRC trans rs2303319 0.504 rs62188960 chr2:162492578 A/C cg06896663 chr8:82754093 SNX16 -0.69 -5.98 -0.31 5.75e-9 Cognitive function; CRC trans rs9650657 0.740 rs10481451 chr8:10649328 A/G cg06636001 chr8:8085503 FLJ10661 -0.46 -6.64 -0.34 1.33e-10 Neuroticism; CRC cis rs875971 0.895 rs12531677 chr7:65769086 G/A cg11764359 chr7:65958608 NA -0.59 -8.77 -0.44 1e-16 Aortic root size; CRC cis rs7927771 0.896 rs12794570 chr11:47658314 C/T cg18512352 chr11:47633146 NA -0.48 -9.59 -0.47 2.21e-19 Subjective well-being; CRC cis rs6840360 0.642 rs11735957 chr4:152427506 G/A cg09659197 chr4:152720779 NA 0.33 6.66 0.34 1.14e-10 Intelligence (multi-trait analysis); CRC cis rs67311347 1.000 rs9822909 chr3:40457084 G/T cg09455208 chr3:40491958 NA 0.47 8.96 0.44 2.53e-17 Renal cell carcinoma; CRC cis rs7216064 1.000 rs6504542 chr17:65836642 T/C cg12091567 chr17:66097778 LOC651250 -0.62 -7.79 -0.39 8.97e-14 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CRC cis rs9309473 0.528 rs7573275 chr2:73552542 G/A cg20560298 chr2:73613845 ALMS1 -0.45 -5.8 -0.3 1.53e-8 Metabolite levels; CRC cis rs7945705 0.818 rs1988708 chr11:8882893 C/A cg00186954 chr11:8933980 ST5;C11orf17 -0.44 -7.21 -0.37 3.99e-12 Hemoglobin concentration; CRC trans rs3733585 0.683 rs6449140 chr4:9936437 G/C cg26043149 chr18:55253948 FECH -0.53 -7.87 -0.4 5.06e-14 Cleft plate (environmental tobacco smoke interaction); CRC cis rs722599 0.748 rs3742783 chr14:75377008 C/T cg08847533 chr14:75593920 NEK9 -0.45 -6.11 -0.32 2.89e-9 IgG glycosylation; CRC cis rs3760982 0.967 rs3760984 chr19:44286762 C/T cg12072164 chr19:44306565 LYPD5 0.42 6.59 0.34 1.77e-10 Breast cancer (estrogen-receptor negative);Breast cancer; CRC cis rs4731207 0.698 rs2896361 chr7:124473825 C/T cg23710748 chr7:124431027 NA 0.38 6.08 0.32 3.42e-9 Cutaneous malignant melanoma; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg23836594 chr17:37894258 GRB7 0.38 7.01 0.36 1.35e-11 Response to antipsychotic treatment; CRC cis rs4141404 0.787 rs4820042 chr22:31589056 T/C cg07713946 chr22:31675144 LIMK2 -0.39 -5.62 -0.3 4e-8 Paclitaxel-induced neuropathy; CRC cis rs6694672 0.764 rs6678066 chr1:197221904 A/G cg13682187 chr1:196946512 CFHR5 0.52 5.74 0.3 2.11e-8 Asthma; CRC cis rs9788333 0.792 rs34479949 chr13:21895574 G/A cg23743428 chr13:21893420 NA -0.45 -8.96 -0.44 2.38e-17 Thiazide-induced adverse metabolic effects in hypertensive patients; CRC cis rs7789940 0.904 rs61294900 chr7:75937212 A/T cg10167463 chr7:75959203 YWHAG -0.68 -8.93 -0.44 3.1e-17 Multiple sclerosis; CRC cis rs6500602 0.702 rs11645519 chr16:4538989 G/A cg08645402 chr16:4508243 NA 0.64 11.45 0.53 8.65e-26 Schizophrenia; CRC cis rs6424115 0.830 rs2502992 chr1:24201919 T/C cg10978503 chr1:24200527 CNR2 0.61 11.06 0.52 2.22e-24 Immature fraction of reticulocytes; CRC cis rs3741404 0.825 rs11604782 chr11:63946650 G/A cg04317338 chr11:64019027 PLCB3 0.42 5.82 0.31 1.36e-8 Platelet count; CRC cis rs11764590 0.671 rs62444906 chr7:2083161 G/T cg23422044 chr7:1970798 MAD1L1 -0.5 -5.97 -0.31 6.23e-9 Neuroticism; CRC cis rs9467603 1.000 rs9467600 chr6:25792768 C/T cg08501292 chr6:25962987 TRIM38 1.08 9.37 0.46 1.18e-18 Intelligence (multi-trait analysis); CRC cis rs6748734 0.625 rs9288743 chr2:241821569 C/G cg16358738 chr2:241808595 AGXT -0.4 -6.98 -0.36 1.59e-11 Urinary metabolites; CRC cis rs2289583 0.642 rs11635266 chr15:75386649 T/C cg14664628 chr15:75095509 CSK 0.46 6.45 0.33 4.1e-10 Systemic lupus erythematosus; CRC cis rs6499255 1.000 rs11641521 chr16:69823081 C/G cg00738113 chr16:70207722 CLEC18C -0.42 -6.02 -0.31 4.75e-9 IgE levels; CRC cis rs17376456 1.000 rs56046246 chr5:93531545 T/G cg21475434 chr5:93447410 FAM172A 0.72 6.95 0.36 1.99e-11 Diabetic retinopathy; CRC cis rs6570726 0.818 rs412350 chr6:145852409 T/C cg13319975 chr6:146136371 FBXO30 -0.46 -6.99 -0.36 1.56e-11 Lobe attachment (rater-scored or self-reported); CRC cis rs910316 1.000 rs3742778 chr14:75538217 A/C cg11812906 chr14:75593930 NEK9 -0.65 -10.52 -0.5 1.68e-22 Height; CRC cis rs832540 1.000 rs832540 chr5:56199202 G/A cg24531977 chr5:56204891 C5orf35 -0.46 -7.0 -0.36 1.43e-11 Coronary artery disease; CRC cis rs17767392 0.756 rs61991195 chr14:71747223 G/T cg13720639 chr14:72061746 SIPA1L1 -0.53 -6.39 -0.33 5.76e-10 Mitral valve prolapse; CRC cis rs3093024 1.000 rs3093024 chr6:167532793 C/T cg19688584 chr6:167529678 CCR6 0.31 5.61 0.3 4.31e-8 Rheumatoid arthritis; CRC cis rs2153535 0.580 rs6920779 chr6:8437624 C/T cg21535247 chr6:8435926 SLC35B3 0.48 7.26 0.37 2.78e-12 Motion sickness; CRC cis rs7552404 0.656 rs11161792 chr1:76336746 C/T cg10523679 chr1:76189770 ACADM 0.74 9.35 0.46 1.38e-18 Blood metabolite levels;Acylcarnitine levels; CRC cis rs427941 0.703 rs201447 chr7:101738384 C/A cg06246474 chr7:101738831 CUX1 0.46 7.16 0.37 5.46e-12 Plasma omega-3 polyunsaturated fatty acid level (eicosapentaenoic acid); CRC cis rs12134245 0.776 rs12122066 chr1:92005140 C/T cg07090678 chr1:91966139 CDC7 0.42 6.8 0.35 5e-11 Breast cancer; CRC cis rs4713118 0.866 rs2179094 chr6:27741825 T/C cg25164649 chr6:28176230 NA 0.6 8.04 0.41 1.66e-14 Parkinson's disease; CRC cis rs891088 0.626 rs12982656 chr19:7194609 C/T cg09779027 chr19:7224513 INSR -0.61 -7.5 -0.38 6.12e-13 Hip circumference adjusted for BMI;Height; CRC cis rs3771570 1.000 rs62190370 chr2:242384194 C/G cg21155796 chr2:242212141 HDLBP 0.64 6.97 0.36 1.69e-11 Prostate cancer; CRC cis rs2257205 0.667 rs8070407 chr17:56709172 G/A cg25885038 chr17:56607967 SEPT4 -0.53 -5.86 -0.31 1.11e-8 Pancreatic cancer; CRC cis rs847649 0.961 rs7456502 chr7:102596022 C/A cg18108683 chr7:102477205 FBXL13 0.58 9.39 0.46 1.03e-18 Morning vs. evening chronotype; CRC cis rs7208859 0.623 rs58089675 chr17:29196764 C/G cg14008862 chr17:28927542 LRRC37B2 0.55 5.74 0.3 2.12e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs10504229 0.728 rs17215753 chr8:58153764 A/G cg11062466 chr8:58055876 NA 0.45 6.11 0.32 2.74e-9 Developmental language disorder (linguistic errors); CRC cis rs17376456 0.825 rs17372615 chr5:93124768 C/T cg21475434 chr5:93447410 FAM172A 0.71 6.8 0.35 4.84e-11 Diabetic retinopathy; CRC cis rs1552244 1.000 rs7651058 chr3:10066964 C/T cg18598329 chr3:10140678 FANCD2;C3orf24 -0.88 -12.17 -0.56 2.12e-28 Alzheimer's disease; CRC cis rs9372498 0.536 rs9489409 chr6:118802721 A/G cg15382696 chr6:118971807 C6orf204 0.58 7.36 0.38 1.53e-12 Diastolic blood pressure; CRC cis rs4076764 0.801 rs12046142 chr1:163375247 G/A cg06092702 chr1:163392909 NA -0.52 -8.18 -0.41 6.32e-15 Motion sickness; CRC trans rs7267979 0.932 rs417110 chr20:25458297 T/C cg17903999 chr18:56338584 MALT1 -0.41 -6.95 -0.36 1.98e-11 Liver enzyme levels (alkaline phosphatase); CRC cis rs6163 0.588 rs67506723 chr10:104509064 G/T cg11453585 chr10:104263688 ACTR1A;SUFU -0.49 -7.61 -0.39 2.98e-13 Waist circumference;Hip circumference; CRC cis rs1008375 0.966 rs12503517 chr4:17698725 G/A cg16339924 chr4:17578868 LAP3 0.48 6.34 0.33 7.7e-10 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs11785693 0.862 rs11786657 chr8:5001792 T/C cg26367366 chr8:4980734 NA 0.67 7.78 0.39 9.49e-14 Neuroticism (multi-trait analysis);Neuroticism; CRC cis rs11148252 0.538 rs9535879 chr13:52704624 T/A cg12458913 chr13:53173898 NA 0.47 7.0 0.36 1.48e-11 Lewy body disease; CRC cis rs13191362 0.810 rs34714603 chr6:163008078 C/T cg06582575 chr6:163149167 PACRG;PARK2 0.71 10.22 0.49 1.72e-21 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs9435341 1.000 rs9435341 chr1:107616641 T/C cg14671364 chr1:107599128 PRMT6 -0.47 -6.64 -0.34 1.28e-10 Facial morphology (factor 21, depth of nasal alae); CRC cis rs6499255 0.951 rs57488237 chr16:69741571 T/C cg04110750 chr16:69646130 NFAT5 -0.54 -7.59 -0.39 3.27e-13 IgE levels; CRC cis rs34779708 0.966 rs878264 chr10:35440581 T/C cg03585969 chr10:35415529 CREM 0.55 7.44 0.38 9.13e-13 Inflammatory bowel disease;Crohn's disease; CRC trans rs2727020 0.538 rs11040373 chr11:49461791 T/C cg11707556 chr5:10655725 ANKRD33B -0.35 -6.35 -0.33 7.06e-10 Coronary artery disease; CRC cis rs13108904 0.870 rs12506095 chr4:1262233 T/C cg21620606 chr4:1342894 KIAA1530 0.38 6.42 0.33 4.82e-10 Obesity-related traits; CRC cis rs9486715 0.867 rs4240553 chr6:96965324 T/C cg06623918 chr6:96969491 KIAA0776 1.03 20.73 0.75 1.2e-61 Headache; CRC cis rs2836974 0.584 rs34436313 chr21:40685246 A/G cg11644478 chr21:40555479 PSMG1 -0.67 -10.33 -0.49 7.74e-22 Cognitive function; CRC cis rs6918586 0.615 rs198824 chr6:26122783 T/C cg18357526 chr6:26021779 HIST1H4A -0.49 -7.44 -0.38 9.1e-13 Schizophrenia; CRC cis rs600231 0.665 rs1784859 chr11:65220749 A/G cg17120908 chr11:65337727 SSSCA1 0.56 8.32 0.42 2.4e-15 Bone mineral density; CRC trans rs3942852 0.568 rs10769314 chr11:48097620 C/T cg15704280 chr7:45808275 SEPT13 -0.68 -9.57 -0.47 2.73e-19 Acute lymphoblastic leukemia (childhood); CRC cis rs6582630 0.572 rs7315897 chr12:38449081 C/T cg13010199 chr12:38710504 ALG10B -0.42 -5.91 -0.31 8.4e-9 Drug-induced liver injury (flucloxacillin); CRC cis rs80264589 1 rs80264589 chr6:26927602 G/A cg16898833 chr6:26189333 HIST1H4D 0.87 6.39 0.33 5.53e-10 Lung cancer;Intelligence (multi-trait analysis); CRC cis rs769267 0.895 rs2916073 chr19:19528324 T/G cg03709012 chr19:19516395 GATAD2A 0.72 11.3 0.53 3.14e-25 Tonsillectomy; CRC cis rs7647973 1.000 rs6774724 chr3:49381911 G/T cg07636037 chr3:49044803 WDR6 0.56 6.45 0.33 4.06e-10 Menarche (age at onset); CRC cis rs1975031 1 rs1975031 chr19:7217601 G/A cg09779027 chr19:7224513 INSR -0.83 -10.39 -0.5 4.65e-22 Perceived unattractiveness to mosquitoes; CRC cis rs1552244 0.882 rs13066757 chr3:10045030 C/A cg08888203 chr3:10149979 C3orf24 0.65 8.75 0.43 1.12e-16 Alzheimer's disease; CRC trans rs10982213 0.830 rs2274163 chr9:117188714 C/T cg11866396 chr17:5322940 RPAIN;NUP88 0.41 6.64 0.34 1.3e-10 Interleukin-6 levels; CRC cis rs595982 0.527 rs56021835 chr19:49369989 G/A cg15549821 chr19:49342101 PLEKHA4 -0.55 -6.47 -0.34 3.47e-10 Red cell distribution width; CRC cis rs35110281 0.807 rs1598206 chr21:45058776 A/G cg04455712 chr21:45112962 RRP1B 0.4 7.72 0.39 1.41e-13 Mean corpuscular volume; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg03617389 chr16:5147251 FAM86A 0.47 7.04 0.36 1.12e-11 Intelligence (multi-trait analysis); CRC cis rs9811920 0.609 rs10936005 chr3:99674093 G/A cg07805332 chr3:99536008 MIR548G;C3orf26 0.53 8.12 0.41 9.16e-15 Axial length; CRC cis rs2354432 0.556 rs7516165 chr1:146866418 G/T cg25205988 chr1:146714368 CHD1L 1.16 9.8 0.48 4.56e-20 Mitochondrial DNA levels; CRC cis rs2836633 0.929 rs8130434 chr21:40036243 C/T cg12884169 chr21:40033163 ERG -0.45 -10.48 -0.5 2.25e-22 Coronary artery disease; CRC cis rs4731207 0.564 rs6466992 chr7:124692166 G/A cg23710748 chr7:124431027 NA -0.39 -6.14 -0.32 2.35e-9 Cutaneous malignant melanoma; CRC cis rs9291683 0.588 rs3756238 chr4:10013202 C/T cg00071950 chr4:10020882 SLC2A9 0.68 13.33 0.59 1.07e-32 Bone mineral density; CRC cis rs9768139 0.566 rs729099 chr7:158114152 C/T cg24154853 chr7:158122151 PTPRN2 0.53 8.9 0.44 3.85e-17 Calcium levels; CRC cis rs4731207 0.596 rs7789392 chr7:124611076 T/A cg23710748 chr7:124431027 NA -0.4 -6.23 -0.32 1.46e-9 Cutaneous malignant melanoma; CRC cis rs2228479 0.850 rs11641147 chr16:89813589 C/T cg06558623 chr16:89946397 TCF25 1.15 10.8 0.51 1.85e-23 Skin colour saturation; CRC cis rs10782582 0.593 rs12131344 chr1:76136437 C/T cg03433033 chr1:76189801 ACADM -0.43 -6.09 -0.32 3.21e-9 Daytime sleep phenotypes; CRC trans rs6076960 0.652 rs3852946 chr20:6255311 C/T cg24759859 chr6:86352639 SYNCRIP 0.46 6.72 0.35 8.14e-11 Smooth-surface caries; CRC cis rs636291 0.517 rs11121579 chr1:10541824 G/C cg17425144 chr1:10567563 PEX14 0.53 12.2 0.56 1.67e-28 Prostate cancer; CRC cis rs10504229 0.728 rs1495867 chr8:58155500 G/T cg21724239 chr8:58056113 NA 0.62 8.38 0.42 1.51e-15 Developmental language disorder (linguistic errors); CRC cis rs977987 0.750 rs4888406 chr16:75432334 G/T cg03315344 chr16:75512273 CHST6 0.52 8.71 0.43 1.56e-16 Dupuytren's disease; CRC cis rs12044355 0.927 rs11577035 chr1:231835941 C/A cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX 0.5 6.81 0.35 4.68e-11 Alzheimer's disease; CRC cis rs317865 0.737 rs73234651 chr4:16196651 G/A cg04764131 chr4:16228633 TAPT1;FLJ39653 0.63 5.7 0.3 2.67e-8 Kidney disease (early stage) in type 1 diabetes; CRC cis rs1707322 0.928 rs6681068 chr1:46398382 G/A cg03146154 chr1:46216737 IPP 0.51 7.09 0.36 8.17e-12 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs2282802 0.685 rs7730245 chr5:139628163 C/A cg26211634 chr5:139558579 C5orf32 0.44 7.72 0.39 1.36e-13 Intelligence (multi-trait analysis); CRC cis rs473651 0.904 rs551859 chr2:239371836 T/C cg08773314 chr2:239334832 ASB1 0.34 7.8 0.4 8.19e-14 Multiple system atrophy; CRC cis rs7605827 0.681 rs63106161 chr2:15537726 T/C cg19274914 chr2:15703543 NA 0.4 5.94 0.31 7.2e-9 Educational attainment (years of education); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg00313973 chr10:99186293 PGAM1 0.42 6.18 0.32 1.87e-9 Intelligence (multi-trait analysis); CRC cis rs9916302 0.904 rs7216086 chr17:37709422 G/A cg15445000 chr17:37608096 MED1 0.4 8.63 0.43 2.6e-16 Glomerular filtration rate (creatinine); CRC cis rs4664308 1.000 rs6759924 chr2:160912747 G/A cg03641300 chr2:160917029 PLA2R1 -0.77 -12.52 -0.57 1.08e-29 Idiopathic membranous nephropathy; CRC cis rs2361718 0.501 rs11869566 chr17:78143248 T/C cg27427491 chr17:78079615 GAA -0.45 -6.15 -0.32 2.28e-9 Yeast infection; CRC cis rs763014 1.000 rs2269558 chr16:682250 C/T cg07343612 chr16:622815 PIGQ -0.78 -12.76 -0.58 1.4e-30 Height; CRC trans rs2303319 0.504 rs12470590 chr2:162493102 A/G cg06896663 chr8:82754093 SNX16 -0.69 -5.98 -0.31 5.75e-9 Cognitive function; CRC cis rs4964805 0.913 rs35945096 chr12:104201929 G/A cg02344784 chr12:104178138 NT5DC3 0.53 7.78 0.39 9.76e-14 Attention deficit hyperactivity disorder; CRC cis rs7107174 1.000 rs2510036 chr11:77966788 G/T cg02023728 chr11:77925099 USP35 0.51 7.25 0.37 3e-12 Testicular germ cell tumor; CRC cis rs7618501 0.633 rs4688757 chr3:50035323 T/C cg24110177 chr3:50126178 RBM5 -0.46 -6.84 -0.35 3.94e-11 Intelligence (multi-trait analysis); CRC cis rs10256972 0.521 rs10280960 chr7:1103697 A/G cg22907277 chr7:1156413 C7orf50 0.41 6.21 0.32 1.61e-9 Longevity;Endometriosis; CRC cis rs6089584 0.888 rs6142927 chr20:60605848 A/G cg06108461 chr20:60628389 TAF4 -0.8 -11.56 -0.54 3.55e-26 Body mass index; CRC trans rs7267979 0.932 rs2387891 chr20:25470328 C/G cg17903999 chr18:56338584 MALT1 -0.41 -6.84 -0.35 3.87e-11 Liver enzyme levels (alkaline phosphatase); CRC cis rs216303 0.642 rs216314 chr12:6136580 T/C cg19878637 chr12:6148451 VWF -0.63 -7.0 -0.36 1.45e-11 Low vWF levels; CRC cis rs6840360 0.642 rs11099815 chr4:152343888 G/T cg09659197 chr4:152720779 NA 0.33 6.55 0.34 2.24e-10 Intelligence (multi-trait analysis); CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg11204671 chr14:24583351 DCAF11 -0.43 -6.2 -0.32 1.69e-9 Myopia (pathological); CRC cis rs2857891 0.909 rs56261447 chr11:6939382 A/C cg17958423 chr11:6947583 ZNF215 0.58 6.08 0.32 3.27e-9 Response to cytadine analogues (cytosine arabinoside); CRC cis rs919433 0.713 rs55642934 chr2:198491110 C/T cg20885578 chr2:198174922 NA 0.35 5.68 0.3 2.96e-8 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC cis rs7089973 0.872 rs7074729 chr10:116632257 C/G cg03647239 chr10:116582469 FAM160B1 0.41 5.62 0.3 4.06e-8 Bipolar disorder or attention deficit hyperactivity disorder; CRC cis rs9359856 0.510 rs4235839 chr6:90472410 A/G cg13799429 chr6:90582589 CASP8AP2 0.77 10.03 0.48 7.73e-21 Bipolar disorder; CRC cis rs1707322 0.964 rs12067716 chr1:46434428 T/A cg06784218 chr1:46089804 CCDC17 0.58 10.4 0.5 4.34e-22 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg11814422 chr18:47018265 SNORD58A;RPL17;SNORD58B 0.48 6.45 0.34 3.91e-10 Thyroid stimulating hormone; CRC cis rs9916302 0.731 rs11868030 chr17:37650332 A/G cg15445000 chr17:37608096 MED1 0.43 9.61 0.47 1.9e-19 Glomerular filtration rate (creatinine); CRC cis rs11764590 0.950 rs55683212 chr7:2078855 G/C cg21155852 chr7:2048760 MAD1L1 -0.48 -6.6 -0.34 1.62e-10 Neuroticism; CRC cis rs832540 0.801 rs7731700 chr5:56111927 C/T cg12311346 chr5:56204834 C5orf35 -0.46 -6.62 -0.34 1.48e-10 Coronary artery disease; CRC cis rs13191362 1.000 rs66534429 chr6:163003322 A/G cg06582575 chr6:163149167 PACRG;PARK2 0.74 10.67 0.51 5.17e-23 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs7493 1.000 rs17166875 chr7:95041271 C/T cg17330251 chr7:94953956 PON1 -0.56 -7.22 -0.37 3.52e-12 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs2806561 0.828 rs604030 chr1:23518227 T/C cg12483005 chr1:23474871 LUZP1 0.49 7.15 0.37 5.58e-12 Height; CRC cis rs17345786 1.000 rs58907984 chr3:101305170 T/G cg11279151 chr3:101281821 RG9MTD1 -0.69 -8.75 -0.43 1.12e-16 Colonoscopy-negative controls vs population controls; CRC cis rs7647973 0.961 rs4955417 chr3:49298205 T/C cg07636037 chr3:49044803 WDR6 0.65 7.97 0.4 2.56e-14 Menarche (age at onset); CRC cis rs7615952 0.641 rs6805074 chr3:125772274 T/A cg05084668 chr3:125655381 ALG1L -0.45 -6.47 -0.34 3.59e-10 Blood pressure (smoking interaction); CRC cis rs853679 0.517 rs9468297 chr6:28118874 G/T cg18032046 chr6:28092343 ZSCAN16 -0.51 -5.93 -0.31 7.47e-9 Depression; CRC cis rs4363385 0.510 rs61811886 chr1:153035743 G/A cg25856811 chr1:152973957 SPRR3 -0.21 -5.61 -0.3 4.3e-8 Inflammatory skin disease; CRC cis rs938554 0.612 rs28592748 chr4:9998605 T/C cg11266682 chr4:10021025 SLC2A9 0.4 6.45 0.34 3.98e-10 Blood metabolite levels; CRC cis rs8180040 0.701 rs7625067 chr3:47095305 T/C cg10298567 chr3:47292165 KIF9 -0.38 -6.1 -0.32 2.99e-9 Colorectal cancer; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg18845289 chr12:121124611 MLEC 0.47 6.17 0.32 2.03e-9 Thyroid stimulating hormone; CRC cis rs2346160 0.867 rs412495 chr6:167688940 C/G cg04673565 chr6:167680447 NA 0.33 5.64 0.3 3.59e-8 Parental extreme longevity (95 years and older); CRC cis rs637571 0.726 rs669371 chr11:65674153 G/T cg26695010 chr11:65641043 EFEMP2 0.42 6.32 0.33 8.3e-10 Eosinophil percentage of white cells; CRC cis rs597539 0.616 rs513476 chr11:68698996 C/T cg06112835 chr11:68658793 MRPL21 0.44 6.94 0.36 2.11e-11 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg04592292 chr19:55987591 ZNF628 0.45 7.26 0.37 2.89e-12 Liver disease severity in Alagille syndrome; CRC trans rs8002861 0.747 rs12866387 chr13:44391936 A/G cg17145862 chr1:211918768 LPGAT1 0.6 10.63 0.51 6.92e-23 Leprosy; CRC trans rs2629046 0.967 rs2602681 chr2:225070767 C/T cg02046017 chr11:70707406 SHANK2 0.36 5.99 0.31 5.36e-9 Height; CRC cis rs875971 0.737 rs7803424 chr7:65880605 T/C cg18876405 chr7:65276391 NA 0.52 9.04 0.45 1.37e-17 Aortic root size; CRC cis rs9906695 0.796 rs11867200 chr17:32575969 A/G cg12698626 chr17:32581466 CCL2 -0.44 -6.22 -0.32 1.47e-9 Monocyte percentage of white cells; CRC cis rs898097 0.625 rs7406464 chr17:80891460 A/G cg15664640 chr17:80829946 TBCD -0.47 -7.9 -0.4 4.31e-14 Breast cancer; CRC cis rs7618915 0.547 rs2118540 chr3:52629386 T/C cg10802521 chr3:52805072 NEK4 -0.59 -8.96 -0.44 2.47e-17 Bipolar disorder; CRC cis rs13108904 0.870 rs2279281 chr4:1245277 T/G cg16405210 chr4:1374714 KIAA1530 -0.45 -6.63 -0.34 1.34e-10 Obesity-related traits; CRC cis rs8077889 0.917 rs6503479 chr17:41917003 A/G cg25876840 chr17:41920477 NA 0.5 7.49 0.38 6.45e-13 Triglycerides; CRC cis rs6860806 0.507 rs2631362 chr5:131707293 A/G cg18301423 chr5:131593218 PDLIM4 -0.38 -6.31 -0.33 9.25e-10 Breast cancer; CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg05966498 chr5:10761293 DAP 0.39 6.4 0.33 5.43e-10 Obesity-related traits; CRC cis rs992157 0.643 rs10191283 chr2:219056755 G/A cg04731861 chr2:219085781 ARPC2 -0.31 -6.52 -0.34 2.63e-10 Colorectal cancer; CRC cis rs9814567 0.964 rs9847788 chr3:134186496 A/C cg06541857 chr3:134203789 ANAPC13;CEP63 -0.38 -5.63 -0.3 3.86e-8 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs7517126 1.000 rs6428364 chr1:196844049 C/T cg13682187 chr1:196946512 CFHR5 -0.35 -5.82 -0.31 1.43e-8 Blood protein levels; CRC cis rs3785574 0.962 rs62077512 chr17:61851435 C/T cg22520471 chr17:61851767 DDX42;CCDC47 0.46 6.38 0.33 5.93e-10 Height; CRC cis rs17023223 0.537 rs10923754 chr1:119668640 T/C cg05756136 chr1:119680316 WARS2 -0.53 -7.02 -0.36 1.24e-11 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for BMI in active individuals; CRC cis rs28386778 0.897 rs3744293 chr17:61841788 T/A cg06601766 chr17:61851465 DDX42;CCDC47 0.45 6.1 0.32 3.06e-9 Prudent dietary pattern; CRC cis rs561341 1.000 rs2470243 chr17:30290955 C/T cg23018236 chr17:30244563 NA -0.65 -7.74 -0.39 1.21e-13 Hip circumference adjusted for BMI; CRC cis rs55702914 0.712 rs12616329 chr2:198148629 T/C cg20885578 chr2:198174922 NA -0.35 -6.12 -0.32 2.63e-9 Major depression and alcohol dependence; CRC cis rs3126085 0.935 rs10888466 chr1:152166223 A/C cg09127314 chr1:152161683 NA -0.53 -6.65 -0.34 1.24e-10 Atopic dermatitis; CRC cis rs904251 0.522 rs882322 chr6:37484103 A/G cg01843034 chr6:37503916 NA -0.43 -8.1 -0.41 1.07e-14 Cognitive performance; CRC cis rs12791968 0.765 rs12794751 chr11:44998769 C/G cg11846598 chr11:44996168 LOC221122 -0.57 -8.43 -0.42 1.13e-15 Inhibitory control; CRC cis rs7552404 0.924 rs114752222 chr1:76180878 C/T cg10523679 chr1:76189770 ACADM 0.93 14.21 0.62 4.51e-36 Blood metabolite levels;Acylcarnitine levels; CRC cis rs9549367 0.865 rs3861721 chr13:113906308 C/T cg18105134 chr13:113819100 PROZ -0.74 -10.54 -0.5 1.38e-22 Platelet distribution width; CRC cis rs4474465 0.646 rs7937417 chr11:78284470 A/G cg27205649 chr11:78285834 NARS2 0.54 7.08 0.36 9.03e-12 Alzheimer's disease (survival time); CRC cis rs910316 1.000 rs4899544 chr14:75546556 C/T cg08847533 chr14:75593920 NEK9 0.93 17.75 0.7 6.21e-50 Height; CRC cis rs875971 1.000 rs811880 chr7:65818646 T/C cg18912574 chr7:65842487 NCRNA00174 0.36 6.28 0.33 1.06e-9 Aortic root size; CRC cis rs9372498 0.536 rs9489395 chr6:118758884 T/C cg10217327 chr6:118973057 C6orf204 0.51 5.75 0.3 2e-8 Diastolic blood pressure; CRC trans rs11098499 0.954 rs4345162 chr4:120312959 G/A cg25214090 chr10:38739885 LOC399744 0.62 9.74 0.47 7.35e-20 Corneal astigmatism; CRC cis rs9467711 0.606 rs9393705 chr6:26361011 G/A cg16898833 chr6:26189333 HIST1H4D 0.75 6.55 0.34 2.26e-10 Autism spectrum disorder or schizophrenia; CRC cis rs28386778 0.897 rs2584601 chr17:61940977 T/C cg11494091 chr17:61959527 GH2 0.58 9.88 0.48 2.57e-20 Prudent dietary pattern; CRC cis rs2811415 0.569 rs1057220 chr3:127799983 A/C cg13719885 chr3:127795394 NA -0.39 -5.88 -0.31 1.03e-8 Lung function (FEV1/FVC); CRC cis rs4665809 1.000 rs12471809 chr2:26307140 A/G cg27170947 chr2:26402098 FAM59B -0.44 -5.83 -0.31 1.3e-8 Gut microbiome composition (summer); CRC cis rs897984 0.762 rs4889604 chr16:30985994 G/T cg00531865 chr16:30841666 NA 0.47 6.59 0.34 1.75e-10 Dementia with Lewy bodies; CRC cis rs2530545 0.620 rs4141269 chr7:34667416 A/T cg14401837 chr7:34697493 NPSR1 0.38 5.95 0.31 6.92e-9 IgG glycosylation; CRC cis rs2836974 0.831 rs2836921 chr21:40516070 C/T cg11644478 chr21:40555479 PSMG1 0.7 9.98 0.48 1.14e-20 Cognitive function; CRC cis rs1832871 0.616 rs55675950 chr6:158773994 T/A cg07165851 chr6:158734300 TULP4 0.6 7.65 0.39 2.28e-13 Height; CRC cis rs7811142 0.887 rs111972532 chr7:100069088 T/C cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.98 12.91 0.58 3.82e-31 Platelet count; CRC cis rs6502050 0.528 rs12942561 chr17:80116639 G/A cg19223190 chr17:80058835 NA 0.39 6.31 0.33 9.07e-10 Life satisfaction; CRC cis rs10991814 1.000 rs77983835 chr9:93956086 C/T cg14446406 chr9:93919335 NA 0.56 6.05 0.32 4e-9 Neutrophil percentage of granulocytes; CRC cis rs765787 0.530 rs1648286 chr15:45517386 G/C cg24006582 chr15:45444508 DUOX1 -0.57 -8.6 -0.43 3.35e-16 Uric acid levels; CRC cis rs5167 0.506 rs7257916 chr19:45482884 T/C cg13119609 chr19:45449297 APOC2 -0.35 -6.49 -0.34 3.08e-10 Blood protein levels; CRC cis rs9381040 0.655 rs7738684 chr6:41038552 G/A cg09580153 chr6:41068724 NFYA;LOC221442 -0.44 -6.41 -0.33 4.97e-10 Alzheimer's disease (late onset); CRC trans rs10504229 1.000 rs73607875 chr8:58173522 T/C cg04077850 chr5:125800366 GRAMD3 0.37 6.27 0.33 1.15e-9 Developmental language disorder (linguistic errors); CRC cis rs3733585 0.699 rs6449178 chr4:9968684 A/G cg11266682 chr4:10021025 SLC2A9 0.47 9.6 0.47 2.11e-19 Cleft plate (environmental tobacco smoke interaction); CRC trans rs7267979 0.844 rs6076343 chr20:25376663 C/T cg17903999 chr18:56338584 MALT1 0.42 6.72 0.35 8.23e-11 Liver enzyme levels (alkaline phosphatase); CRC cis rs9462027 0.583 rs2814947 chr6:34653268 T/C cg07306190 chr6:34760872 UHRF1BP1 -0.35 -6.32 -0.33 8.42e-10 Systemic lupus erythematosus; CRC cis rs9733 0.519 rs11204717 chr1:150709129 T/A cg17724175 chr1:150552817 MCL1 0.58 9.16 0.45 5.58e-18 Tonsillectomy; CRC cis rs6952808 0.575 rs6950330 chr7:1953606 T/C cg21782813 chr7:2030301 MAD1L1 0.39 7.29 0.37 2.33e-12 Bipolar disorder and schizophrenia; CRC cis rs2066819 1.000 rs11171806 chr12:56733531 A/G cg26714650 chr12:56694279 CS 1.17 9.85 0.48 3.04e-20 Psoriasis vulgaris; CRC cis rs11997175 0.549 rs4349945 chr8:33654323 T/C ch.8.33884649F chr8:33765107 NA 0.48 7.69 0.39 1.74e-13 Body mass index; CRC cis rs6714710 0.580 rs57681139 chr2:98454473 C/T cg26665480 chr2:98280029 ACTR1B 0.52 7.18 0.37 4.53e-12 Posterior cortical atrophy and Alzheimer's disease; CRC cis rs1223397 0.651 rs202023 chr6:13304658 C/T cg20827128 chr6:13274284 PHACTR1 0.4 6.01 0.31 4.93e-9 Blood pressure; CRC cis rs2549003 0.870 rs61175929 chr5:131821548 C/G cg00255919 chr5:131827918 IRF1 0.59 11.92 0.55 1.77e-27 Asthma (sex interaction); CRC trans rs12438356 0.686 rs76047987 chr15:69476929 C/G cg26416341 chr12:54718712 COPZ1 0.64 5.96 0.31 6.33e-9 CTACK levels; CRC cis rs2228479 0.702 rs17233253 chr16:89828437 A/G cg06656553 chr16:89960601 TCF25 -0.7 -5.76 -0.3 1.93e-8 Skin colour saturation; CRC cis rs9868809 0.881 rs3821876 chr3:48668394 G/T cg00383909 chr3:49044727 WDR6 0.77 7.67 0.39 1.93e-13 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; CRC trans rs2018683 0.707 rs2391718 chr7:28974988 T/C cg19402173 chr7:128379420 CALU -0.44 -6.35 -0.33 7.01e-10 Response to irinotecan and platinum-based chemotherapy in non-small-cell lung cancer; CRC cis rs1129187 0.755 rs9471976 chr6:42920549 G/T cg02353165 chr6:42928485 GNMT 0.72 12.27 0.56 9.72e-29 Alzheimer's disease in APOE e4+ carriers; CRC cis rs7259376 0.902 rs4932763 chr19:22603922 C/A cg02657401 chr19:22469223 NA 0.31 6.75 0.35 6.86e-11 Menopause (age at onset); CRC cis rs4713118 0.869 rs9283881 chr6:27715255 A/T cg15786705 chr6:28176104 NA 0.55 7.78 0.39 9.76e-14 Parkinson's disease; CRC cis rs853679 0.517 rs4711164 chr6:28115156 C/T cg12963246 chr6:28129442 ZNF389 0.49 5.7 0.3 2.71e-8 Depression; CRC cis rs9976767 0.646 rs876497 chr21:43841905 G/A cg23042151 chr21:43824109 UBASH3A -0.4 -6.78 -0.35 5.71e-11 Type 1 diabetes; CRC cis rs6460942 0.591 rs4721079 chr7:12337742 A/G cg20607287 chr7:12443886 VWDE -0.55 -6.18 -0.32 1.92e-9 Coronary artery disease; CRC cis rs4964805 1.000 rs11111792 chr12:104194857 C/G cg02344784 chr12:104178138 NT5DC3 0.55 8.33 0.42 2.21e-15 Attention deficit hyperactivity disorder; CRC cis rs2839186 0.770 rs2280956 chr21:47642323 C/G cg05896524 chr21:47604654 C21orf56 -0.46 -6.98 -0.36 1.61e-11 Testicular germ cell tumor; CRC cis rs7224685 0.501 rs4790171 chr17:4022899 T/C cg05562828 chr17:3906858 NA -0.66 -11.73 -0.54 8.97e-27 Type 2 diabetes; CRC trans rs1005277 0.505 rs1208689 chr10:38097775 C/G cg27523141 chr10:43048294 ZNF37B 0.44 6.48 0.34 3.27e-10 Extrinsic epigenetic age acceleration; CRC cis rs7737355 0.947 rs79018835 chr5:130798461 C/A cg06307176 chr5:131281290 NA -0.43 -6.32 -0.33 8.59e-10 Life satisfaction; CRC cis rs172166 0.516 rs1225618 chr6:28129713 A/C cg23161317 chr6:28129485 ZNF389 0.39 5.86 0.31 1.13e-8 Cardiac Troponin-T levels; CRC trans rs6703335 0.870 rs10803142 chr1:243598234 A/G cg27343001 chr19:16739049 MED26 0.49 7.11 0.36 7.47e-12 Schizophrenia;Schizophrenia, schizoaffective disorder or bipolar disorder; CRC cis rs6500395 0.708 rs28449353 chr16:48555134 T/A cg04672837 chr16:48644449 N4BP1 0.4 5.92 0.31 7.91e-9 Response to tocilizumab in rheumatoid arthritis; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg24691105 chr13:50700331 DLEU2 0.38 6.01 0.31 5.05e-9 Intelligence (multi-trait analysis); CRC cis rs10256972 0.616 rs4998392 chr7:1113344 A/C cg22907277 chr7:1156413 C7orf50 0.5 7.33 0.37 1.75e-12 Longevity;Endometriosis; CRC cis rs2179367 0.887 rs6570965 chr6:149717476 C/A cg07828024 chr6:149772892 ZC3H12D -0.36 -6.08 -0.32 3.31e-9 Dupuytren's disease; CRC cis rs6121246 0.909 rs6089070 chr20:30377773 A/G cg13852791 chr20:30311386 BCL2L1 -0.69 -10.43 -0.5 3.31e-22 Mean corpuscular hemoglobin; CRC cis rs4132509 0.649 rs12140040 chr1:243871922 G/A cg21452805 chr1:244014465 NA 0.57 6.21 0.32 1.58e-9 RR interval (heart rate); CRC cis rs9916302 0.904 rs8079355 chr17:37473018 G/A cg00129232 chr17:37814104 STARD3 0.55 8.26 0.41 3.49e-15 Glomerular filtration rate (creatinine); CRC cis rs1348850 0.567 rs1405714 chr2:178538584 A/G cg02961200 chr2:178257176 LOC100130691;AGPS -0.57 -7.98 -0.4 2.52e-14 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs3858526 0.920 rs11511938 chr11:5928793 A/G cg02574844 chr11:5959923 NA -0.43 -6.11 -0.32 2.77e-9 DNA methylation (variation); CRC cis rs1707322 0.752 rs6703748 chr1:46095976 G/A cg03146154 chr1:46216737 IPP 0.66 9.6 0.47 2.07e-19 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC trans rs7618501 0.521 rs868891 chr3:49949071 A/G cg21665057 chr3:196295764 WDR53;FBXO45 0.45 6.43 0.33 4.61e-10 Intelligence (multi-trait analysis); CRC cis rs9486719 1.000 rs12191653 chr6:96903898 T/C cg06623918 chr6:96969491 KIAA0776 -0.8 -9.28 -0.46 2.39e-18 Migraine;Coronary artery disease; CRC cis rs9322817 0.593 rs9404579 chr6:105229807 T/C cg02098413 chr6:105308735 HACE1 -0.44 -8.16 -0.41 7.43e-15 Thyroid stimulating hormone; CRC cis rs7809950 0.953 rs2253271 chr7:107201252 G/C cg23024343 chr7:107201750 COG5 -0.6 -8.4 -0.42 1.35e-15 Coronary artery disease; CRC cis rs60871478 0.704 rs62432895 chr7:822050 C/G cg13844804 chr7:814759 HEATR2 0.65 8.51 0.42 6.08e-16 Cerebrospinal P-tau181p levels; CRC cis rs6582630 0.555 rs56228141 chr12:38518652 T/G cg13010199 chr12:38710504 ALG10B 0.48 6.4 0.33 5.21e-10 Drug-induced liver injury (flucloxacillin); CRC cis rs4268898 0.662 rs35624938 chr2:24576651 T/C cg06627628 chr2:24431161 ITSN2 -0.82 -11.2 -0.53 7.17e-25 Asthma; CRC cis rs34779708 0.706 rs36027395 chr10:35550323 T/A cg03585969 chr10:35415529 CREM 0.5 6.36 0.33 6.69e-10 Inflammatory bowel disease;Crohn's disease; CRC cis rs9894429 0.646 rs6565609 chr17:79592267 G/A cg09655341 chr17:79618100 PDE6G -0.35 -6.01 -0.31 4.93e-9 Eye color traits; CRC cis rs9303542 0.559 rs1042822 chr17:46620095 G/T cg04904318 chr17:46607828 HOXB1 -0.53 -6.18 -0.32 1.93e-9 Ovarian cancer;Epithelial ovarian cancer; CRC cis rs7072216 0.690 rs113195335 chr10:100175532 A/C cg26618903 chr10:100175079 PYROXD2 -0.54 -8.95 -0.44 2.75e-17 Metabolite levels; CRC trans rs7395662 0.926 rs10742848 chr11:48468788 T/G cg21153622 chr11:89784906 NA -0.51 -8.08 -0.41 1.22e-14 HDL cholesterol; CRC cis rs7616330 0.790 rs2140131 chr3:71044545 A/G cg01511742 chr3:71112437 FOXP1 -0.54 -6.42 -0.33 4.84e-10 QT interval; CRC cis rs28829049 0.731 rs7537573 chr1:19373605 C/T cg22333259 chr1:19394757 NA 0.35 5.62 0.3 4.02e-8 QRS duration in Tripanosoma cruzi seropositivity; CRC cis rs9549328 0.544 rs66893681 chr13:113617499 A/G cg17524180 chr13:113633600 MCF2L 0.52 9.5 0.46 4.44e-19 Systolic blood pressure; CRC cis rs67340775 0.541 rs200964 chr6:27866943 G/C cg08798685 chr6:27730294 NA -0.55 -5.97 -0.31 6.01e-9 Lung cancer in ever smokers; CRC cis rs7618915 0.547 rs11714419 chr3:52628816 A/G cg10802521 chr3:52805072 NEK4 -0.59 -8.97 -0.44 2.37e-17 Bipolar disorder; CRC cis rs7618915 0.501 rs2079929 chr3:52765646 C/T cg18099408 chr3:52552593 STAB1 -0.47 -7.89 -0.4 4.59e-14 Bipolar disorder; CRC cis rs12024301 0.557 rs77708076 chr1:183625280 G/A cg11505048 chr1:183622726 RGL1;APOBEC4 0.78 6.93 0.36 2.18e-11 Peripheral arterial disease (traffic-related air pollution interaction); CRC trans rs1814175 0.645 rs10839448 chr11:49938930 G/A cg03929089 chr4:120376271 NA -0.9 -15.65 -0.65 1.22e-41 Height; CRC trans rs4272382 1 rs4272382 chr8:8433488 C/T cg09373786 chr8:93156639 NA 0.66 5.96 0.31 6.53e-9 Response to cytidine analogues (gemcitabine); CRC trans rs7618501 1.000 rs1491986 chr3:49739086 C/T cg21582582 chr3:182698605 DCUN1D1 -0.56 -8.25 -0.41 3.82e-15 Intelligence (multi-trait analysis); CRC cis rs9926296 0.546 rs7187436 chr16:89845110 A/T cg27121462 chr16:89883253 FANCA 0.58 9.42 0.46 8.11e-19 Vitiligo; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg25367318 chr6:138725211 HEBP2 0.47 6.83 0.35 4.17e-11 Response to antipsychotic treatment; CRC cis rs17401966 0.931 rs12137880 chr1:10388620 T/C cg19773385 chr1:10388646 KIF1B -0.71 -11.54 -0.54 4.3e-26 Hepatocellular carcinoma; CRC trans rs11039798 0.688 rs12277029 chr11:48852833 G/T cg03929089 chr4:120376271 NA 0.63 6.01 0.31 4.92e-9 Axial length; CRC cis rs10971721 0.822 rs72729357 chr9:34041168 G/A cg13495928 chr9:33750294 PRSS3 0.55 5.63 0.3 3.91e-8 Body mass index; CRC trans rs7267979 0.903 rs2500423 chr20:25374882 G/A cg17903999 chr18:56338584 MALT1 0.41 6.58 0.34 1.86e-10 Liver enzyme levels (alkaline phosphatase); CRC cis rs9905704 0.918 rs369184 chr17:56709086 C/T cg12560992 chr17:57184187 TRIM37 0.56 7.64 0.39 2.46e-13 Testicular germ cell tumor; CRC cis rs3096299 0.685 rs4238830 chr16:89540241 C/T cg08392591 chr16:89556376 ANKRD11 0.42 5.78 0.3 1.69e-8 Multiple myeloma (IgH translocation); CRC cis rs853679 0.882 rs3757188 chr6:28107357 T/C cg15786705 chr6:28176104 NA 0.7 5.78 0.3 1.74e-8 Depression; CRC cis rs12701220 0.894 rs10257744 chr7:1045612 C/T cg00990874 chr7:1149470 C7orf50 -0.58 -6.76 -0.35 6.24e-11 Bronchopulmonary dysplasia; CRC cis rs617791 0.530 rs55947178 chr11:65754230 G/A cg09783858 chr11:65769428 EIF1AD;BANF1 0.49 7.31 0.37 2.1e-12 Breast cancer; CRC cis rs7666738 0.830 rs10440379 chr4:98902822 G/T cg05340658 chr4:99064831 C4orf37 0.57 8.69 0.43 1.7e-16 Colonoscopy-negative controls vs population controls; CRC cis rs9372498 0.536 rs62422189 chr6:118907053 C/T cg24463073 chr6:118973353 C6orf204 0.5 6.32 0.33 8.29e-10 Diastolic blood pressure; CRC cis rs10503871 0.625 rs4416792 chr8:30303833 A/C cg26383811 chr8:30366931 RBPMS 0.46 7.3 0.37 2.23e-12 Metabolite levels (X-11787); CRC cis rs13108904 0.935 rs1732102 chr4:1277924 T/C cg02018176 chr4:1364513 KIAA1530 -0.45 -7.79 -0.39 8.84e-14 Obesity-related traits; CRC cis rs3741151 0.686 rs11235809 chr11:73290163 A/G cg17517138 chr11:73019481 ARHGEF17 0.56 5.81 0.31 1.48e-8 GIP levels in response to oral glucose tolerance test (120 minutes); CRC cis rs10870270 1.000 rs4880250 chr10:133773919 G/A cg08754478 chr10:133766260 PPP2R2D -0.66 -9.29 -0.46 2.22e-18 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; CRC cis rs11122272 0.735 rs2790883 chr1:231532726 A/G cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.58 -8.57 -0.43 3.94e-16 Hemoglobin concentration; CRC cis rs17376456 0.569 rs2045020 chr5:93224466 T/C cg25358565 chr5:93447407 FAM172A -0.7 -8.24 -0.41 4.16e-15 Diabetic retinopathy; CRC cis rs2976388 0.647 rs2244163 chr8:143784500 T/G cg20041105 chr8:143859282 LYNX1 0.43 7.67 0.39 1.97e-13 Urinary tract infection frequency; CRC cis rs28829049 0.597 rs2296107 chr1:19476649 C/G cg13387374 chr1:19411106 UBR4 0.4 5.78 0.3 1.69e-8 QRS duration in Tripanosoma cruzi seropositivity; CRC cis rs208520 0.690 rs2797693 chr6:66868985 T/C cg07460842 chr6:66804631 NA -1.07 -14.89 -0.63 1.12e-38 Exhaled nitric oxide output; CRC cis rs853679 0.569 rs9348798 chr6:28143011 G/A cg21251018 chr6:28226885 NKAPL 0.47 6.04 0.32 4.16e-9 Depression; CRC cis rs6570726 0.791 rs9403734 chr6:145931459 C/G cg23711669 chr6:146136114 FBXO30 0.74 12.63 0.57 4.47e-30 Lobe attachment (rater-scored or self-reported); CRC cis rs1862618 0.573 rs2591962 chr5:56237155 G/A cg18230493 chr5:56204884 C5orf35 0.88 11.92 0.55 1.84e-27 Initial pursuit acceleration; CRC cis rs7849270 1.000 rs7855278 chr9:131921365 A/C cg13538475 chr9:131942899 NA 0.32 6.08 0.32 3.38e-9 Blood metabolite ratios; CRC cis rs8177253 0.665 rs12639304 chr3:133441594 A/T cg24879335 chr3:133465180 TF 0.32 6.02 0.32 4.58e-9 Iron status biomarkers; CRC trans rs7395662 0.857 rs116589099 chr11:48786205 A/T cg21153622 chr11:89784906 NA 0.44 6.99 0.36 1.49e-11 HDL cholesterol; CRC cis rs11955398 0.625 rs12655515 chr5:59974098 G/C cg02684056 chr5:59996105 DEPDC1B 0.41 5.94 0.31 7.14e-9 Intelligence (multi-trait analysis); CRC cis rs6479527 0.875 rs10435923 chr9:96781569 T/C cg14459158 chr9:96720562 NA 0.36 6.49 0.34 3.12e-10 Esophageal adenocarcinoma; CRC cis rs1355223 0.506 rs7947848 chr11:34866220 T/C cg11058730 chr11:34937778 PDHX;APIP -0.43 -6.07 -0.32 3.52e-9 Systemic lupus erythematosus and Systemic sclerosis; CRC cis rs1570884 0.516 rs2146144 chr13:50170245 C/T cg03651054 chr13:50194643 NA 0.34 6.88 0.35 3.01e-11 Sum basophil neutrophil counts;Sum neutrophil eosinophil counts;Neutrophil count;Myeloid white cell count;Granulocyte count; CRC cis rs10791323 0.559 rs10750548 chr11:133729469 A/G cg03690763 chr11:133734501 NA -0.39 -6.4 -0.33 5.25e-10 Childhood ear infection; CRC cis rs35883536 0.513 rs6577180 chr1:101016939 G/A cg06223162 chr1:101003688 GPR88 0.42 7.86 0.4 5.64e-14 Monocyte count; CRC trans rs1005277 0.579 rs2505237 chr10:38438898 T/G cg17830980 chr10:43048298 ZNF37B -0.58 -9.8 -0.48 4.78e-20 Extrinsic epigenetic age acceleration; CRC cis rs1799949 1.000 rs33926631 chr17:41304463 T/C cg05368731 chr17:41323189 NBR1 0.69 10.52 0.5 1.73e-22 Menopause (age at onset); CRC cis rs3743266 0.613 rs8027901 chr15:60733464 A/C cg21667061 chr15:60772094 NARG2 -0.28 -5.74 -0.3 2.12e-8 Menarche (age at onset); CRC cis rs7666738 0.753 rs6826709 chr4:98714553 C/G cg17366294 chr4:99064904 C4orf37 0.41 6.83 0.35 4.19e-11 Colonoscopy-negative controls vs population controls; CRC cis rs7772486 0.764 rs7745696 chr6:146162829 T/C cg13319975 chr6:146136371 FBXO30 -0.41 -6.2 -0.32 1.68e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs4969178 0.965 rs4969186 chr17:76398404 C/G cg05887092 chr17:76393375 PGS1 0.55 10.1 0.49 4.47e-21 HDL cholesterol levels; CRC cis rs897984 0.574 rs11647284 chr16:31077335 G/A cg02466173 chr16:30829666 NA -0.59 -8.6 -0.43 3.31e-16 Dementia with Lewy bodies; CRC cis rs62244186 0.748 rs4682987 chr3:44674996 C/T cg10263370 chr3:44754102 ZNF502 -0.39 -6.5 -0.34 3.02e-10 Depressive symptoms; CRC cis rs798554 0.679 rs2533868 chr7:2886559 G/A cg19346786 chr7:2764209 NA -0.37 -6.45 -0.33 4.08e-10 Height; CRC cis rs9926296 0.643 rs12596429 chr16:89841374 T/C cg27121462 chr16:89883253 FANCA 0.39 5.97 0.31 6.04e-9 Vitiligo; CRC cis rs7666738 0.830 rs10000573 chr4:99048785 G/C cg05340658 chr4:99064831 C4orf37 0.6 9.35 0.46 1.4e-18 Colonoscopy-negative controls vs population controls; CRC cis rs10886503 0.623 rs10886504 chr10:121256112 C/A cg17804342 chr10:121271663 RGS10 0.52 6.41 0.33 5.11e-10 Obstetric antiphospholipid syndrome; CRC cis rs28386778 0.687 rs59596917 chr17:61806264 T/A cg23090583 chr17:61904693 PSMC5;FTSJ3 1.03 19.28 0.73 5.63e-56 Prudent dietary pattern; CRC cis rs950169 1.000 rs35648189 chr15:84740748 T/C cg24253500 chr15:84953950 NA 0.37 6.18 0.32 1.92e-9 Schizophrenia; CRC cis rs4713118 0.586 rs6905516 chr6:28086478 A/G cg02631126 chr6:28058918 ZSCAN12L1 0.29 5.87 0.31 1.05e-8 Parkinson's disease; CRC cis rs6543140 0.964 rs6543142 chr2:103082006 T/C cg04239558 chr2:103089729 SLC9A4 0.37 6.59 0.34 1.72e-10 Blood protein levels; CRC trans rs13046373 0.905 rs4816372 chr21:32077414 A/T cg16669491 chr19:19314215 NR2C2AP -0.44 -6.43 -0.33 4.51e-10 HDL cholesterol; CRC cis rs2455601 1.000 rs11042108 chr11:8906021 G/A cg09997546 chr11:8931473 C11orf17;ST5 -0.51 -6.12 -0.32 2.62e-9 Schizophrenia; CRC cis rs1878931 0.582 rs27231 chr16:3434966 C/T cg02880119 chr16:3481970 NA -0.41 -5.77 -0.3 1.84e-8 Body mass index (adult); CRC cis rs4689388 0.926 rs11725500 chr4:6293919 C/G cg14416269 chr4:6271139 WFS1 0.41 6.79 0.35 5.27e-11 Type 2 diabetes and other traits;Type 2 diabetes; CRC cis rs1223397 0.702 rs13191897 chr6:13288428 G/A cg20827128 chr6:13274284 PHACTR1 0.56 6.61 0.34 1.55e-10 Blood pressure; CRC cis rs2274273 0.840 rs6573013 chr14:55735873 A/C cg23234261 chr14:55582407 NA -0.31 -6.25 -0.33 1.31e-9 Protein biomarker; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg07982263 chr16:1359166 UBE2I 0.41 6.0 0.31 5.32e-9 Intelligence (multi-trait analysis); CRC cis rs2274273 0.588 rs7158791 chr14:55828607 A/G cg10130446 chr14:55658398 DLGAP5 -0.43 -6.04 -0.32 4.28e-9 Protein biomarker; CRC cis rs9322193 0.886 rs9485408 chr6:149940024 T/C cg07701084 chr6:150067640 NUP43 0.54 7.96 0.4 2.81e-14 Lung cancer; CRC cis rs1506636 0.962 rs7811830 chr7:123320183 G/C cg03229431 chr7:123269106 ASB15 -0.73 -11.75 -0.54 7.47e-27 Plateletcrit;Platelet count; CRC cis rs7659604 0.539 rs7686084 chr4:122764725 A/C cg19748678 chr4:122722346 EXOSC9 0.66 10.43 0.5 3.45e-22 Type 2 diabetes; CRC cis rs7552404 1.000 rs4949874 chr1:76161889 T/C cg10523679 chr1:76189770 ACADM 0.83 11.55 0.54 4.04e-26 Blood metabolite levels;Acylcarnitine levels; CRC cis rs4731207 0.596 rs6963594 chr7:124609233 C/T cg23710748 chr7:124431027 NA -0.39 -6.23 -0.32 1.46e-9 Cutaneous malignant melanoma; CRC cis rs807029 0.577 rs701835 chr10:102762127 A/G cg04662943 chr10:102668895 NA 0.57 6.61 0.34 1.54e-10 Ejection fraction in Tripanosoma cruzi seropositivity; CRC trans rs10504229 1.000 rs116995796 chr8:58181960 G/A cg04077850 chr5:125800366 GRAMD3 0.37 6.23 0.32 1.46e-9 Developmental language disorder (linguistic errors); CRC cis rs7772486 0.754 rs9497401 chr6:146051271 T/C cg05347473 chr6:146136440 FBXO30 -0.38 -5.67 -0.3 3.1e-8 Lobe attachment (rater-scored or self-reported); CRC trans rs4263408 0.934 rs9683743 chr4:39703194 A/C cg07238657 chr1:154973705 ZBTB7B -0.42 -6.16 -0.32 2.15e-9 Plasma amyloid beta peptide concentrations (ABx-40); CRC cis rs2153535 0.580 rs1577467 chr6:8444241 G/A cg07606381 chr6:8435919 SLC35B3 0.68 10.86 0.51 1.08e-23 Motion sickness; CRC cis rs1862618 0.754 rs252899 chr5:56188569 G/C cg22800045 chr5:56110881 MAP3K1 0.6 6.38 0.33 5.99e-10 Initial pursuit acceleration; CRC cis rs910316 0.783 rs11850751 chr14:75590113 A/T cg11812906 chr14:75593930 NEK9 0.6 9.34 0.46 1.52e-18 Height; CRC cis rs875971 1.000 rs937495 chr7:65779798 A/G cg00343986 chr7:65444356 GUSB -0.43 -6.19 -0.32 1.78e-9 Aortic root size; CRC cis rs40363 0.671 rs4786425 chr16:3537650 A/G cg00484396 chr16:3507460 NAT15 -0.65 -6.48 -0.34 3.35e-10 Tuberculosis; CRC cis rs7224685 0.871 rs8081968 chr17:3984117 C/T cg09597638 chr17:3907349 NA 0.47 7.53 0.38 4.87e-13 Type 2 diabetes; CRC cis rs10504229 0.565 rs7010503 chr8:58147127 G/A cg02725872 chr8:58115012 NA -0.59 -11.18 -0.52 8.12e-25 Developmental language disorder (linguistic errors); CRC cis rs79976124 0.837 rs11751145 chr6:66642039 T/C cg07460842 chr6:66804631 NA 0.74 9.24 0.45 3.04e-18 Type 2 diabetes; CRC cis rs734999 0.545 rs10910111 chr1:2542653 A/G cg18854424 chr1:2615690 NA 0.49 9.73 0.47 7.65e-20 Ulcerative colitis; CRC cis rs7827545 1.000 rs4909910 chr8:135565201 T/C cg13086574 chr8:135490821 ZFAT -0.36 -6.06 -0.32 3.73e-9 Hypertension (SNP x SNP interaction); CRC cis rs4148883 0.675 rs28762430 chr4:100119257 C/A cg13256891 chr4:100009986 ADH5 0.43 6.26 0.33 1.2e-9 Alcohol dependence; CRC cis rs11722228 1.000 rs4697695 chr4:9915850 C/T cg00071950 chr4:10020882 SLC2A9 0.44 6.68 0.35 1.01e-10 Gout;Urate levels;Serum uric acid levels; CRC cis rs9811920 0.609 rs17174947 chr3:99598884 C/T cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G 0.46 6.18 0.32 1.87e-9 Axial length; CRC trans rs6076960 0.652 rs3852946 chr20:6255311 C/T cg21095983 chr6:86352623 SYNCRIP 0.51 7.61 0.39 2.98e-13 Smooth-surface caries; CRC cis rs2380220 0.872 rs7750757 chr6:95997118 A/G cg04719120 chr6:96025338 MANEA 0.64 7.39 0.38 1.23e-12 Behavioural disinhibition (generation interaction); CRC cis rs1448094 0.511 rs7967183 chr12:86216845 T/G cg02569458 chr12:86230093 RASSF9 0.42 7.16 0.37 5.21e-12 Major depressive disorder; CRC cis rs6424115 0.708 rs11803575 chr1:24182348 A/T cg15997130 chr1:24165203 NA -0.59 -7.62 -0.39 2.67e-13 Immature fraction of reticulocytes; CRC cis rs1065852 0.526 rs9623489 chr22:42397026 A/G cg22189786 chr22:42395067 WBP2NL 0.44 6.45 0.34 4.01e-10 Response to serotonin reuptake inhibitors in major depressive disorder (plasma drug and metabolite levels); CRC cis rs11711311 0.955 rs9860642 chr3:113419211 G/A cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.49 -6.44 -0.33 4.34e-10 IgG glycosylation; CRC cis rs853679 0.550 rs1237875 chr6:28173010 A/G cg25164649 chr6:28176230 NA -0.78 -11.02 -0.52 2.93e-24 Depression; CRC cis rs904251 0.523 rs2797798 chr6:37481437 C/T cg25019722 chr6:37503610 NA -0.47 -8.77 -0.44 9.97e-17 Cognitive performance; CRC cis rs796364 0.813 rs4672686 chr2:201065044 A/G cg25936922 chr2:200820526 C2orf60;C2orf47 0.54 5.99 0.31 5.39e-9 Schizophrenia; CRC cis rs10463316 0.817 rs6880228 chr5:150778145 A/T cg03212797 chr5:150827313 SLC36A1 0.48 7.6 0.39 3.15e-13 Metabolite levels (Pyroglutamine); CRC cis rs870825 0.616 rs4443323 chr4:185629805 C/A cg04058563 chr4:185651563 MLF1IP 0.72 8.06 0.41 1.43e-14 Blood protein levels; CRC cis rs10191773 0.584 rs72831633 chr2:112945932 T/G cg24977338 chr2:113188963 RGPD8;RGPD5 -0.66 -5.75 -0.3 2.07e-8 Yeast infection; CRC cis rs4713118 0.513 rs149972 chr6:27983227 C/T cg06470822 chr6:28175283 NA 0.82 12.33 0.56 5.84e-29 Parkinson's disease; CRC trans rs4824093 0.610 rs9627798 chr22:50317857 G/A cg09872104 chr7:134855509 C7orf49 -0.79 -7.27 -0.37 2.67e-12 Amyotrophic lateral sclerosis (sporadic); CRC cis rs4819052 1.000 rs3746980 chr21:46711580 C/T cg11663144 chr21:46675770 NA -0.78 -11.19 -0.52 7.8e-25 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs35110281 0.594 rs230641 chr21:44915441 T/C cg01579765 chr21:45077557 HSF2BP 0.31 5.66 0.3 3.21e-8 Mean corpuscular volume; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg00291661 chr16:30581198 ZNF688 -0.36 -6.05 -0.32 3.9e-9 Liver disease severity in Alagille syndrome; CRC cis rs9649213 0.537 rs6971825 chr7:97979548 C/T cg24562669 chr7:97807699 LMTK2 0.44 7.42 0.38 1.01e-12 Prostate cancer (SNP x SNP interaction); CRC cis rs12701220 0.948 rs12690826 chr7:1081618 A/G cg26240231 chr7:1148101 C7orf50 -0.48 -6.62 -0.34 1.46e-10 Bronchopulmonary dysplasia; CRC cis rs4663866 0.901 rs2304672 chr2:239186589 C/G cg16914508 chr2:239161102 PER2 -0.7 -7.51 -0.38 5.56e-13 Irritable bowel syndrome; CRC cis rs7811142 0.887 rs111972532 chr7:100069088 T/C cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.6 7.49 0.38 6.25e-13 Platelet count; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg05019311 chr17:4807065 CHRNE 0.45 6.83 0.35 4.13e-11 Intelligence (multi-trait analysis); CRC cis rs9733 0.596 rs72702585 chr1:150696427 G/A cg18016565 chr1:150552671 MCL1 0.45 6.52 0.34 2.57e-10 Tonsillectomy; CRC cis rs1799949 0.896 rs35908185 chr17:41255111 A/T cg19454999 chr17:41278357 BRCA1;NBR2 0.57 8.92 0.44 3.35e-17 Menopause (age at onset); CRC cis rs1799949 1.000 rs8176297 chr17:41203325 T/A cg19454999 chr17:41278357 BRCA1;NBR2 0.54 8.53 0.43 5.37e-16 Menopause (age at onset); CRC trans rs17655565 1.000 rs73309373 chr12:52701409 C/T cg05090392 chr7:157209531 DNAJB6 0.6 6.19 0.32 1.76e-9 Plasma amyloid beta peptide concentrations (ABx-42); CRC cis rs3820068 0.532 rs72645862 chr1:15920366 A/G cg24675056 chr1:15929824 NA 0.47 6.29 0.33 1.01e-9 Systolic blood pressure; CRC cis rs67311347 0.544 rs13062243 chr3:40336789 G/A cg09455208 chr3:40491958 NA 0.31 6.34 0.33 7.75e-10 Renal cell carcinoma; CRC cis rs6951245 0.554 rs58210047 chr7:1149381 G/A cg18402987 chr7:1209562 NA 0.56 6.76 0.35 6.39e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs67311347 0.955 rs11717036 chr3:40379578 G/T cg09455208 chr3:40491958 NA -0.41 -8.28 -0.42 3.06e-15 Renal cell carcinoma; CRC trans rs208520 0.954 rs1468153 chr6:67009054 A/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.84 10.16 0.49 2.8e-21 Exhaled nitric oxide output; CRC cis rs9399135 0.967 rs4896125 chr6:135342569 C/T cg22676075 chr6:135203613 NA 0.41 6.38 0.33 5.97e-10 Red blood cell count; CRC cis rs4819052 0.851 rs4819040 chr21:46659762 T/C cg02159808 chr21:46707872 POFUT2;LOC642852 0.44 6.03 0.32 4.37e-9 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs2276314 1.000 rs1540042 chr18:33555236 C/T cg19628046 chr18:33552617 C18orf21 0.49 6.85 0.35 3.74e-11 Endometriosis;Drug-induced torsades de pointes; CRC cis rs1129187 0.902 rs10948059 chr6:42928461 C/T cg02353165 chr6:42928485 GNMT 0.93 18.99 0.72 8.11e-55 Alzheimer's disease in APOE e4+ carriers; CRC cis rs72781680 0.716 rs2712068 chr2:23984000 A/G cg08917208 chr2:24149416 ATAD2B 0.56 6.45 0.33 4.07e-10 Lymphocyte counts; CRC cis rs9487051 0.872 rs9400269 chr6:109606065 C/G cg01475377 chr6:109611718 NA -0.48 -8.98 -0.44 2.15e-17 Reticulocyte fraction of red cells; CRC cis rs1552244 1.000 rs17032396 chr3:10153559 A/G cg10729496 chr3:10149963 C3orf24 -0.55 -7.19 -0.37 4.35e-12 Alzheimer's disease; CRC trans rs11581859 0.950 rs60591961 chr1:99371878 A/C cg12183875 chr3:169587454 LRRC31 0.27 6.43 0.33 4.37e-10 Response to cognitive-behavioural therapy in anxiety disorder; CRC cis rs896854 0.654 rs4735340 chr8:95976251 A/T cg09323728 chr8:95962352 TP53INP1 -0.45 -7.47 -0.38 7.48e-13 Type 2 diabetes; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg05119084 chr18:46477127 SMAD7 0.42 7.09 0.36 8.41e-12 Liver disease severity in Alagille syndrome; CRC cis rs9640161 0.617 rs73170169 chr7:150008036 G/A cg12556325 chr7:150026731 C7orf29;LRRC61 -0.48 -7.16 -0.37 5.37e-12 Blood protein levels;Circulating chemerin levels; CRC cis rs72634258 0.945 rs397349 chr1:8074872 A/C cg26816564 chr1:7831052 VAMP3 0.44 5.67 0.3 3.1e-8 Inflammatory bowel disease; CRC cis rs10504229 0.683 rs17194792 chr8:58107195 A/C cg21724239 chr8:58056113 NA 0.81 9.75 0.47 6.8e-20 Developmental language disorder (linguistic errors); CRC cis rs965469 0.947 rs6139087 chr20:3329062 T/C cg25506879 chr20:3388711 C20orf194 -0.39 -5.81 -0.31 1.44e-8 IFN-related cytopenia; CRC trans rs7897194 0.592 rs10828066 chr10:20783978 T/C cg12686133 chr12:4758424 NDUFA9 -0.53 -5.98 -0.31 5.78e-9 Bipolar disorder; CRC cis rs7246657 0.943 rs10422074 chr19:37894236 T/C cg23950597 chr19:37808831 NA -0.54 -6.52 -0.34 2.58e-10 Coronary artery calcification; CRC cis rs10979 0.597 rs9496691 chr6:143910970 T/C cg25407410 chr6:143891975 LOC285740 -0.67 -8.94 -0.44 2.93e-17 Hypospadias; CRC cis rs6831352 0.918 rs29001211 chr4:100051941 C/T cg12011299 chr4:100065546 ADH4 -0.49 -9.21 -0.45 4.04e-18 Alcohol dependence; CRC cis rs13191362 0.507 rs2846566 chr6:163059714 G/A cg21926612 chr6:163149169 PACRG;PARK2 -0.61 -9.33 -0.46 1.58e-18 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs9858542 0.953 rs9878943 chr3:49434654 G/A cg03060546 chr3:49711283 APEH -0.48 -6.75 -0.35 6.61e-11 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs17065868 0.764 rs73188717 chr13:45019390 G/C cg10246903 chr13:45222710 NA 0.58 6.4 0.33 5.41e-10 Antineutrophil cytoplasmic antibody-associated vasculitis; CRC cis rs10927875 0.518 rs945416 chr1:16344402 G/A cg22431228 chr1:16359049 CLCNKA -0.38 -6.97 -0.36 1.74e-11 Dilated cardiomyopathy; CRC cis rs10992471 0.702 rs10820967 chr9:95101729 C/G cg13798575 chr9:95087839 CENPP;NOL8 -0.49 -7.03 -0.36 1.22e-11 Visceral adipose tissue/subcutaneous adipose tissue ratio; CRC cis rs7613875 0.521 rs4688754 chr3:50074641 G/T cg05623727 chr3:50126028 RBM5 -0.59 -10.13 -0.49 3.65e-21 Body mass index; CRC trans rs6601327 0.585 rs11249934 chr8:9510830 C/T cg16141378 chr3:129829833 LOC729375 -0.41 -6.3 -0.33 9.77e-10 Multiple myeloma (hyperdiploidy); CRC cis rs2976388 0.609 rs1560986 chr8:143789775 T/C cg15511327 chr8:143859410 LYNX1 0.41 7.41 0.38 1.06e-12 Urinary tract infection frequency; CRC cis rs78545713 0.649 rs79308455 chr6:26224377 A/G cg01420254 chr6:26195488 NA 0.66 5.87 0.31 1.04e-8 Iron status biomarkers (total iron binding capacity); CRC cis rs2075371 0.965 rs1862049 chr7:133978344 A/T cg11752832 chr7:134001865 SLC35B4 0.48 7.48 0.38 6.95e-13 Mean platelet volume; CRC cis rs6545883 0.929 rs2252662 chr2:61670731 T/C cg15711740 chr2:61764176 XPO1 -0.42 -5.67 -0.3 3.18e-8 Tuberculosis; CRC cis rs3796352 1.000 rs36090694 chr3:53010742 T/C cg27565382 chr3:53032988 SFMBT1 0.72 5.86 0.31 1.15e-8 Immune reponse to smallpox (secreted IL-2); CRC cis rs7811142 0.830 rs6979910 chr7:99940630 A/C cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.86 11.39 0.53 1.47e-25 Platelet count; CRC cis rs8060686 0.668 rs8046355 chr16:68205214 T/A cg26727032 chr16:67993705 SLC12A4 -0.58 -8.83 -0.44 6.34e-17 HDL cholesterol;Metabolic syndrome; CRC cis rs11711311 0.712 rs3773683 chr3:113341007 T/C cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.54 -7.22 -0.37 3.61e-12 IgG glycosylation; CRC cis rs7772486 0.720 rs1890171 chr6:146072114 T/C cg23711669 chr6:146136114 FBXO30 -0.75 -12.86 -0.58 6.07e-31 Lobe attachment (rater-scored or self-reported); CRC cis rs965469 0.901 rs6037586 chr20:3368114 G/A cg25506879 chr20:3388711 C20orf194 -0.39 -5.74 -0.3 2.11e-8 IFN-related cytopenia; CRC cis rs853679 0.607 rs200489 chr6:27798257 T/C cg26587870 chr6:27730563 NA -0.6 -5.89 -0.31 9.43e-9 Depression; CRC cis rs1862618 0.754 rs252899 chr5:56188569 G/C cg20203395 chr5:56204925 C5orf35 -0.71 -8.15 -0.41 7.76e-15 Initial pursuit acceleration; CRC cis rs12410462 1.000 rs12410462 chr1:227667790 A/G cg23173402 chr1:227635558 NA -0.65 -7.42 -0.38 9.76e-13 Major depressive disorder; CRC cis rs6748734 1.000 rs11893118 chr2:241828308 C/G cg07537917 chr2:241836409 C2orf54 -0.23 -6.74 -0.35 7.19e-11 Urinary metabolites; CRC cis rs344364 0.511 rs1742462 chr16:1946062 A/C cg03013636 chr16:1946785 NA 0.57 6.99 0.36 1.54e-11 Glomerular filtration rate in chronic kidney disease; CRC cis rs863345 0.504 rs857714 chr1:158566972 C/T cg12129480 chr1:158549410 OR10X1 0.33 7.1 0.36 7.65e-12 Pneumococcal bacteremia; CRC cis rs10751667 0.666 rs7394958 chr11:965944 C/G ch.11.42038R chr11:967971 AP2A2 0.58 9.98 0.48 1.16e-20 Alzheimer's disease (late onset); CRC cis rs17125944 0.505 rs17125746 chr14:53236079 C/T cg00686598 chr14:53173677 PSMC6 1.09 10.15 0.49 3.11e-21 Alzheimer's disease (late onset); CRC cis rs892961 0.932 rs11658267 chr17:75411884 C/T cg01320579 chr17:75405842 SEPT9 -0.35 -5.65 -0.3 3.45e-8 Airflow obstruction; CRC cis rs939584 1.000 rs11127487 chr2:639900 C/T cg03610516 chr2:642275 NA 0.42 5.88 0.31 9.94e-9 Body mass index; CRC cis rs875971 0.660 rs3857686 chr7:66036191 C/T cg18876405 chr7:65276391 NA -0.6 -10.83 -0.51 1.4e-23 Aortic root size; CRC cis rs3008870 0.755 rs2755254 chr1:67470855 C/T cg08660285 chr1:67390436 MIER1;WDR78 0.54 7.56 0.38 3.92e-13 Lymphocyte percentage of white cells; CRC cis rs6546550 0.901 rs6739780 chr2:70138111 G/A cg02498382 chr2:70120550 SNRNP27 -0.56 -9.52 -0.46 3.78e-19 Prevalent atrial fibrillation; CRC cis rs9902453 0.808 rs8069669 chr17:28239502 C/T cg26525008 chr17:28256777 EFCAB5;SSH2 0.71 11.96 0.55 1.32e-27 Coffee consumption (cups per day); CRC cis rs7605378 0.752 rs769960 chr2:200710706 G/T cg17644776 chr2:200775616 C2orf69 -0.49 -7.27 -0.37 2.66e-12 Osteoporosis; CRC cis rs8180040 0.726 rs4234465 chr3:47026885 C/G cg27129171 chr3:47204927 SETD2 0.63 9.96 0.48 1.3e-20 Colorectal cancer; CRC cis rs4665809 1.000 rs10048648 chr2:26320315 T/C cg27170947 chr2:26402098 FAM59B -0.45 -6.2 -0.32 1.67e-9 Gut microbiome composition (summer); CRC trans rs459571 0.629 rs441233 chr9:136876021 A/G cg09836344 chr4:1243392 C4orf42;CTBP1 0.89 13.67 0.6 5.57e-34 Platelet distribution width; CRC cis rs1008375 1.000 rs13106338 chr4:17676871 G/T cg04450456 chr4:17643702 FAM184B -0.38 -5.97 -0.31 6.11e-9 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs775227 0.574 rs35765657 chr3:113078384 C/T cg18753928 chr3:113234510 CCDC52 -0.55 -6.74 -0.35 7.03e-11 Dental caries; CRC cis rs7215564 0.908 rs2340773 chr17:78744395 T/C cg09596252 chr17:78655493 RPTOR -0.57 -5.95 -0.31 7.01e-9 Myopia (pathological); CRC cis rs6570726 0.764 rs376257 chr6:145862949 G/A cg13319975 chr6:146136371 FBXO30 -0.46 -6.84 -0.35 3.9e-11 Lobe attachment (rater-scored or self-reported); CRC cis rs875971 0.660 rs10263935 chr7:66096028 A/G cg25985355 chr7:65971099 NA -0.34 -6.05 -0.32 3.92e-9 Aortic root size; CRC cis rs798554 0.724 rs798498 chr7:2795882 T/G cg19717773 chr7:2847554 GNA12 -0.43 -6.56 -0.34 2.07e-10 Height; CRC cis rs4563143 0.675 rs112383987 chr19:29261081 C/T cg03161606 chr19:29218774 NA 0.52 6.52 0.34 2.68e-10 Methadone dose in opioid dependence; CRC cis rs172166 0.637 rs1225592 chr6:28150242 G/A cg23161317 chr6:28129485 ZNF389 0.47 6.73 0.35 7.5e-11 Cardiac Troponin-T levels; CRC cis rs1005277 0.579 rs176886 chr10:38403974 C/T cg17219203 chr10:38645113 HSD17B7P2 -0.41 -5.76 -0.3 1.97e-8 Extrinsic epigenetic age acceleration; CRC cis rs477895 0.653 rs7939784 chr11:63910153 C/T cg19465662 chr11:63993652 NUDT22;TRPT1 0.73 8.97 0.44 2.22e-17 Mean platelet volume; CRC cis rs10871290 0.507 rs3851731 chr16:74485788 C/T cg01733217 chr16:74700730 RFWD3 0.72 11.29 0.53 3.4e-25 Breast cancer; CRC cis rs644799 0.610 rs1255179 chr11:95472097 A/G cg25622487 chr11:95524042 FAM76B;CEP57 0.49 7.16 0.37 5.28e-12 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs2153535 0.601 rs9505474 chr6:8539794 C/G cg07606381 chr6:8435919 SLC35B3 0.69 11.29 0.53 3.23e-25 Motion sickness; CRC trans rs4824093 0.610 rs12106611 chr22:50242686 G/A cg09872104 chr7:134855509 C7orf49 -0.84 -7.38 -0.38 1.29e-12 Amyotrophic lateral sclerosis (sporadic); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg15568066 chr10:43904326 HNRNPF 0.42 6.0 0.31 5.31e-9 Intelligence (multi-trait analysis); CRC cis rs4319547 0.586 rs7956480 chr12:122817507 A/G cg23029597 chr12:123009494 RSRC2 -0.5 -6.15 -0.32 2.24e-9 Body mass index; CRC cis rs11229555 0.574 rs72919749 chr11:58323467 T/C cg15696309 chr11:58395628 NA -0.87 -9.41 -0.46 8.56e-19 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; CRC cis rs73206853 0.764 rs28840785 chr12:110844920 C/G cg12870014 chr12:110450643 ANKRD13A 0.85 10.18 0.49 2.4e-21 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC cis rs12586317 0.514 rs61100068 chr14:35400232 A/T cg16230307 chr14:35515116 FAM177A1 0.89 10.39 0.5 4.63e-22 Psoriasis; CRC cis rs6963495 0.818 rs55983796 chr7:105170941 C/T cg02135003 chr7:105160482 PUS7 -0.92 -12.46 -0.57 1.94e-29 Bipolar disorder (body mass index interaction); CRC cis rs3741151 0.892 rs61705659 chr11:73012101 T/G cg17517138 chr11:73019481 ARHGEF17 0.69 7.33 0.37 1.82e-12 GIP levels in response to oral glucose tolerance test (120 minutes); CRC cis rs10540 0.908 rs12792111 chr11:520921 G/C cg19913688 chr11:428466 ANO9 -0.68 -6.94 -0.36 2.06e-11 Body mass index; CRC cis rs13108904 0.539 rs13135102 chr4:1330983 A/C cg23123621 chr4:1343375 KIAA1530 0.36 5.72 0.3 2.34e-8 Obesity-related traits; CRC cis rs2070677 0.736 rs7895560 chr10:135431038 G/A cg20169779 chr10:135381914 SYCE1 -0.81 -11.36 -0.53 1.91e-25 Gout; CRC trans rs2840044 1.000 rs225251 chr17:33951228 A/C cg19694781 chr19:47549865 TMEM160 -0.48 -7.58 -0.39 3.65e-13 Response to radiotherapy in cancer (late toxicity); CRC cis rs6867032 0.834 rs4526149 chr5:1990166 G/A cg26168224 chr5:2018326 NA -0.79 -12.05 -0.55 5.85e-28 Gut microbiome composition (winter); CRC cis rs13191362 1.000 rs71567659 chr6:163001736 G/A cg21926612 chr6:163149169 PACRG;PARK2 0.8 11.25 0.53 4.59e-25 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs6963495 0.818 rs56055535 chr7:105163574 C/A cg02135003 chr7:105160482 PUS7 -0.9 -12.2 -0.56 1.71e-28 Bipolar disorder (body mass index interaction); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg09417889 chr1:155164873 MIR92B 0.42 6.09 0.32 3.24e-9 Intelligence (multi-trait analysis); CRC cis rs9814567 0.752 rs7649910 chr3:134241310 A/T cg06541857 chr3:134203789 ANAPC13;CEP63 -0.41 -6.27 -0.33 1.16e-9 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs73206853 0.841 rs73206886 chr12:110851190 T/G cg12870014 chr12:110450643 ANKRD13A 0.83 10.0 0.48 1.03e-20 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg25750404 chr12:6579648 VAMP1 0.54 7.21 0.37 3.77e-12 Thyroid stimulating hormone; CRC cis rs35306767 0.903 rs10904577 chr10:922077 A/G cg20503657 chr10:835505 NA 0.94 11.83 0.55 3.85e-27 Eosinophil percentage of granulocytes; CRC trans rs4824093 0.610 rs73443923 chr22:50285348 C/T cg09872104 chr7:134855509 C7orf49 -0.82 -6.17 -0.32 1.98e-9 Amyotrophic lateral sclerosis (sporadic); CRC cis rs6502050 0.799 rs9911129 chr17:80087819 C/T cg02741985 chr17:80059408 CCDC57 0.43 7.13 0.37 6.48e-12 Life satisfaction; CRC cis rs992157 0.731 rs1399132 chr2:219159770 G/A cg04880052 chr2:219191631 PNKD 0.41 6.67 0.35 1.06e-10 Colorectal cancer; CRC cis rs7811142 1.000 rs4989959 chr7:100032288 T/C cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.15 17.3 0.69 3.94e-48 Platelet count; CRC cis rs9611519 0.894 rs4821990 chr22:41438710 A/C cg03806693 chr22:41940476 POLR3H -0.58 -7.43 -0.38 9.45e-13 Neuroticism; CRC cis rs9527 0.637 rs11191424 chr10:104625886 G/A cg04362960 chr10:104952993 NT5C2 0.6 8.6 0.43 3.37e-16 Arsenic metabolism; CRC cis rs13064411 0.696 rs7613546 chr3:113228019 G/A cg18753928 chr3:113234510 CCDC52 -0.7 -10.77 -0.51 2.31e-23 Response to simvastatin treatment (PCSK9 protein level change); CRC cis rs514406 0.505 rs269293 chr1:53187767 A/C cg25767906 chr1:53392781 SCP2 -0.38 -5.93 -0.31 7.8e-9 Monocyte count; CRC cis rs12681288 0.862 rs2701898 chr8:1020812 C/T cg04851639 chr8:1020857 NA -0.37 -7.31 -0.37 2.1e-12 Schizophrenia; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg12989104 chr16:48645051 N4BP1 0.38 6.03 0.32 4.33e-9 Liver disease severity in Alagille syndrome; CRC cis rs1403694 0.515 rs1648722 chr3:186448989 C/T cg04611788 chr3:186434169 KNG1 -0.58 -8.39 -0.42 1.45e-15 Blood protein levels; CRC cis rs6860806 0.507 rs156322 chr5:131653925 C/T cg18758796 chr5:131593413 PDLIM4 0.4 6.21 0.32 1.59e-9 Breast cancer; CRC cis rs8044995 0.563 rs55968019 chr16:68398111 G/A cg05110241 chr16:68378359 PRMT7 -0.74 -7.77 -0.39 1.01e-13 Schizophrenia; CRC cis rs12143943 0.866 rs4252713 chr1:204510528 G/A cg17419461 chr1:204415978 PIK3C2B 0.39 6.05 0.32 4.05e-9 Cognitive performance; CRC cis rs4731207 0.596 rs3900363 chr7:124667961 C/A cg23710748 chr7:124431027 NA -0.38 -6.06 -0.32 3.73e-9 Cutaneous malignant melanoma; CRC cis rs7208859 0.623 rs9896603 chr17:29078512 C/G cg01831904 chr17:28903510 LRRC37B2 -0.62 -6.41 -0.33 5.05e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs6951245 1.000 rs74652290 chr7:1090109 G/A cg03188948 chr7:1209495 NA 0.6 6.31 0.33 9.03e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs2976388 0.647 rs2585154 chr8:143783485 C/T cg04969067 chr8:143858791 LYNX1 0.42 7.05 0.36 1.06e-11 Urinary tract infection frequency; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg13316255 chr15:75165642 SCAMP2 0.37 6.02 0.31 4.74e-9 Liver disease severity in Alagille syndrome; CRC cis rs736408 0.688 rs2239551 chr3:52818579 A/G cg08222913 chr3:52553049 STAB1 0.33 5.77 0.3 1.79e-8 Bipolar disorder; CRC cis rs4285028 0.747 rs6791882 chr3:121373058 T/C cg20356878 chr3:121714668 ILDR1 -0.44 -5.97 -0.31 6.14e-9 Multiple sclerosis; CRC cis rs992157 0.710 rs13026485 chr2:219057984 C/T cg00012203 chr2:219082015 ARPC2 -0.59 -9.77 -0.47 5.92e-20 Colorectal cancer; CRC cis rs270601 0.770 rs10463891 chr5:131597392 C/T cg02033258 chr5:131593261 PDLIM4 -0.48 -9.12 -0.45 7.55e-18 Acylcarnitine levels; CRC cis rs10504229 0.769 rs17215649 chr8:58152791 A/G cg02290350 chr8:58132656 NA -0.51 -6.57 -0.34 1.98e-10 Developmental language disorder (linguistic errors); CRC trans rs2303319 0.504 rs1449641 chr2:162619567 T/C cg10498984 chr16:28874827 SH2B1 -0.73 -6.28 -0.33 1.04e-9 Cognitive function; CRC cis rs344364 0.511 rs1742473 chr16:1953095 T/C cg09830162 chr16:1889614 FAHD1;C16orf73 -0.73 -9.08 -0.45 1.04e-17 Glomerular filtration rate in chronic kidney disease; CRC cis rs13108904 0.901 rs4974594 chr4:1300480 C/T cg02018176 chr4:1364513 KIAA1530 -0.4 -6.61 -0.34 1.55e-10 Obesity-related traits; CRC cis rs1707322 1.000 rs7538978 chr1:46505054 C/T cg06784218 chr1:46089804 CCDC17 -0.51 -8.91 -0.44 3.68e-17 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs72615157 0.606 rs941288 chr7:99776808 G/A cg00814883 chr7:100076585 TSC22D4 -0.51 -5.94 -0.31 7.21e-9 Lung function (FEV1/FVC); CRC cis rs2739330 0.828 rs2877178 chr22:24251517 C/T cg10819733 chr22:24237672 NA -0.35 -5.93 -0.31 7.77e-9 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs9393692 0.620 rs9393696 chr6:26291591 T/C cg13736514 chr6:26305472 NA -0.45 -7.51 -0.38 5.48e-13 Educational attainment; CRC cis rs12476592 0.602 rs6708804 chr2:63807269 G/A cg10828910 chr2:63850056 LOC388955 0.49 6.24 0.33 1.34e-9 Childhood ear infection; CRC cis rs644799 1.000 rs564675 chr11:95561873 C/T cg25478527 chr11:95522999 CEP57;FAM76B 0.52 7.86 0.4 5.6e-14 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs4713118 0.513 rs183244 chr6:28031838 C/A cg12273811 chr6:28175739 NA 0.56 7.94 0.4 3.3e-14 Parkinson's disease; CRC cis rs6546324 0.625 rs2861703 chr2:67861053 T/C cg15745817 chr2:67799979 NA -0.55 -9.43 -0.46 7.35e-19 Endometriosis; CRC trans rs853679 0.769 rs17720293 chr6:28214698 C/T cg06606381 chr12:133084897 FBRSL1 -1.24 -9.94 -0.48 1.63e-20 Depression; CRC trans rs1814175 0.617 rs6486020 chr11:49769149 T/G cg15704280 chr7:45808275 SEPT13 -0.96 -17.2 -0.69 9.1e-48 Height; CRC cis rs1865721 0.771 rs724764 chr18:73139742 C/T cg26385618 chr18:73139727 C18orf62 -0.39 -6.0 -0.31 5.22e-9 Intelligence; CRC cis rs4972806 0.739 rs10834 chr2:177042087 A/G cg09355771 chr2:177043147 NA 0.61 8.47 0.42 8.23e-16 IgG glycosylation; CRC cis rs4980532 1 rs4980532 chr11:63680719 C/T cg04362095 chr11:63592001 C11orf84 -0.4 -5.66 -0.3 3.34e-8 Pulse pressure; CRC cis rs2204008 0.548 rs8189475 chr12:38037115 C/T cg13010199 chr12:38710504 ALG10B 0.48 7.02 0.36 1.25e-11 Bladder cancer; CRC cis rs7487075 0.897 rs2897968 chr12:46763686 G/A cg22049899 chr12:47219821 SLC38A4 0.34 6.21 0.32 1.58e-9 Itch intensity from mosquito bite; CRC cis rs8031584 0.958 rs7168641 chr15:31235452 G/A cg08704250 chr15:31115839 NA -0.42 -7.73 -0.39 1.28e-13 Huntington's disease progression; CRC cis rs524281 0.506 rs512421 chr11:65985168 C/T cg16950941 chr11:66035639 RAB1B -0.49 -6.12 -0.32 2.69e-9 Electroencephalogram traits; CRC cis rs7737355 0.947 rs10477736 chr5:130922125 T/C cg06307176 chr5:131281290 NA 0.5 7.06 0.36 1.01e-11 Life satisfaction; CRC cis rs4243830 0.850 rs10779790 chr1:6608435 A/G cg22792644 chr1:6614718 TAS1R1;NOL9 -0.81 -9.91 -0.48 2.02e-20 Body mass index; CRC cis rs1003719 0.715 rs2835653 chr21:38558636 G/A cg10648535 chr21:38446584 PIGP;TTC3 -0.48 -6.67 -0.35 1.06e-10 Eye color traits; CRC cis rs4423214 0.840 rs1792234 chr11:71182018 T/C cg05163923 chr11:71159392 DHCR7 -0.63 -7.62 -0.39 2.65e-13 Vitamin D levels; CRC trans rs7180079 1.000 rs1117087 chr15:64598823 T/G cg22857141 chr5:123707481 NA 0.48 6.09 0.32 3.14e-9 Monocyte count; CRC cis rs9837602 1.000 rs1688771 chr3:99503359 T/A cg07805332 chr3:99536008 MIR548G;C3orf26 0.45 5.92 0.31 8.25e-9 Breast cancer; CRC cis rs1609391 0.543 rs7651085 chr3:136625339 C/G cg15507776 chr3:136538369 TMEM22 0.34 6.16 0.32 2.18e-9 Neuroticism; CRC cis rs8114671 0.562 rs6058120 chr20:33402829 A/G cg24642439 chr20:33292090 TP53INP2 0.37 5.98 0.31 5.74e-9 Height; CRC cis rs9372498 0.536 rs9489447 chr6:118900846 G/A cg18833306 chr6:118973337 C6orf204 0.44 5.75 0.3 2.04e-8 Diastolic blood pressure; CRC cis rs7215564 0.730 rs34484282 chr17:78684663 G/A cg09596252 chr17:78655493 RPTOR 0.56 6.18 0.32 1.87e-9 Myopia (pathological); CRC cis rs2739330 0.796 rs2154594 chr22:24254055 A/G cg18538332 chr22:24372958 LOC391322 0.73 11.67 0.54 1.42e-26 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs853679 0.546 rs200949 chr6:27835435 A/G cg15845792 chr6:28175446 NA 0.74 7.07 0.36 9.34e-12 Depression; CRC trans rs7647973 0.626 rs6809879 chr3:49834571 A/G cg21665057 chr3:196295764 WDR53;FBXO45 0.6 6.68 0.35 1e-10 Menarche (age at onset); CRC cis rs57994353 0.826 rs34619169 chr9:139327277 G/A cg14119001 chr9:139324193 INPP5E -0.4 -5.97 -0.31 6.16e-9 Eosinophil counts;Cutaneous squamous cell carcinoma; CRC cis rs4400599 1.000 rs4540651 chr1:154128672 G/A cg05139571 chr1:154127138 NUP210L 0.44 6.7 0.35 9.13e-11 Platelet distribution width; CRC cis rs7772486 0.875 rs6930975 chr6:146387111 C/T cg23711669 chr6:146136114 FBXO30 0.63 10.77 0.51 2.22e-23 Lobe attachment (rater-scored or self-reported); CRC cis rs1997103 0.954 rs2177807 chr7:55391002 G/T cg17469321 chr7:55412551 NA -0.61 -10.47 -0.5 2.42e-22 QRS interval (sulfonylurea treatment interaction); CRC cis rs10499694 0.844 rs10499695 chr7:50618604 A/G cg14593290 chr7:50529359 DDC -0.42 -6.0 -0.31 5.1e-9 Body mass index; CRC cis rs1401999 1.000 rs6805913 chr3:183662924 T/G cg20387954 chr3:183756860 HTR3D 0.46 7.75 0.39 1.15e-13 Anterior chamber depth; CRC cis rs1448094 0.740 rs4919774 chr12:86337560 G/T cg00310523 chr12:86230176 RASSF9 0.44 7.36 0.38 1.5e-12 Major depressive disorder; CRC cis rs9549260 0.564 rs9646110 chr13:41308301 A/T cg21288729 chr13:41239152 FOXO1 -0.38 -5.9 -0.31 8.92e-9 Red blood cell count; CRC cis rs7811142 0.830 rs6948685 chr7:99970188 C/T cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.12 16.01 0.66 4.45e-43 Platelet count; CRC cis rs2180341 1.000 rs6569483 chr6:127658855 G/A cg24812749 chr6:127587940 RNF146 0.94 13.66 0.6 5.88e-34 Breast cancer; CRC cis rs6460942 0.908 rs117451929 chr7:12265149 A/T cg06484146 chr7:12443880 VWDE -0.63 -6.47 -0.34 3.48e-10 Coronary artery disease; CRC cis rs8062405 1.000 rs4788102 chr16:28873398 G/A cg08761264 chr16:28874980 SH2B1 -0.44 -5.83 -0.31 1.33e-8 Cognitive ability (multi-trait analysis);Cognitive ability; CRC trans rs9825823 0.617 rs2083264 chr3:61074229 A/G cg14984920 chr7:25164393 CYCS 0.44 6.22 0.32 1.53e-9 Depressive symptom measurement or major depressive disorder; CRC cis rs780096 0.546 rs6547626 chr2:27646770 C/T cg02592271 chr2:27665507 KRTCAP3 -0.27 -6.16 -0.32 2.08e-9 Total body bone mineral density; CRC cis rs763121 0.853 rs2281019 chr22:39064378 T/A cg06022373 chr22:39101656 GTPBP1 0.8 12.71 0.57 2.19e-30 Menopause (age at onset); CRC cis rs12745968 0.589 rs10747446 chr1:93108402 G/A cg17283838 chr1:93427260 FAM69A -0.47 -6.38 -0.33 5.84e-10 Bipolar disorder and schizophrenia; CRC cis rs8180040 0.800 rs56250009 chr3:47279497 G/C cg02527881 chr3:46936655 PTH1R 0.35 5.98 0.31 5.85e-9 Colorectal cancer; CRC cis rs9300255 0.722 rs12298826 chr12:123829028 A/G cg00376283 chr12:123451042 ABCB9 -0.54 -7.18 -0.37 4.78e-12 Neutrophil percentage of white cells; CRC cis rs9291683 0.595 rs13150928 chr4:10052961 G/T cg00071950 chr4:10020882 SLC2A9 0.65 12.27 0.56 9.26e-29 Bone mineral density; CRC cis rs1862618 0.802 rs252900 chr5:56185281 T/A cg24531977 chr5:56204891 C5orf35 -0.84 -10.92 -0.52 6.54e-24 Initial pursuit acceleration; CRC trans rs10060123 1.000 rs28712275 chr5:125684934 T/A ch.6.113866684R chr6:113759991 NA -0.38 -5.99 -0.31 5.61e-9 Visceral adipose tissue adjusted for BMI;Visceral adipose tissue; CRC cis rs4654899 0.931 rs4654730 chr1:21229286 A/T cg02927042 chr1:21476669 EIF4G3 -0.47 -7.56 -0.38 4.04e-13 Superior frontal gyrus grey matter volume; CRC cis rs7208859 0.623 rs8079891 chr17:29058863 G/A cg13385521 chr17:29058706 SUZ12P 0.7 7.85 0.4 5.96e-14 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs10256972 0.713 rs10435026 chr7:1065948 A/G cg16145915 chr7:1198662 ZFAND2A -0.31 -5.83 -0.31 1.31e-8 Longevity;Endometriosis; CRC cis rs17253792 0.732 rs8017891 chr14:56172967 A/G cg01858014 chr14:56050164 KTN1 0.63 6.32 0.33 8.44e-10 Putamen volume; CRC cis rs2032447 0.672 rs9379811 chr6:25955197 G/C cg03264133 chr6:25882463 NA -0.52 -7.4 -0.38 1.12e-12 Intelligence (multi-trait analysis); CRC cis rs4727963 0.811 rs7458859 chr7:122711358 C/T cg03640110 chr7:122635026 TAS2R16 0.32 5.86 0.31 1.12e-8 Adverse response to chemotherapy (neutropenia/leucopenia) (docetaxel); CRC trans rs3942852 0.774 rs1039481 chr11:48182237 G/A cg15704280 chr7:45808275 SEPT13 -0.75 -9.35 -0.46 1.43e-18 Acute lymphoblastic leukemia (childhood); CRC cis rs6752107 0.967 rs6431661 chr2:234167421 C/T cg07618928 chr2:234183455 ATG16L1;SCARNA5 0.64 11.03 0.52 2.69e-24 Crohn's disease;Inflammatory bowel disease; CRC cis rs4927850 0.957 rs4927851 chr3:195751853 A/G cg12923728 chr3:195709715 SDHAP1 -0.71 -11.07 -0.52 2.01e-24 Pancreatic cancer; CRC cis rs7647973 0.626 rs62262672 chr3:49655927 T/A cg13072238 chr3:49761600 GMPPB 0.54 5.84 0.31 1.29e-8 Menarche (age at onset); CRC cis rs1881396 0.947 rs4666010 chr2:27878686 T/C cg27432699 chr2:27873401 GPN1 0.64 8.16 0.41 7.22e-15 Nonalcoholic fatty liver disease; CRC cis rs992157 0.697 rs13384682 chr2:219069137 G/A cg04731861 chr2:219085781 ARPC2 -0.32 -6.85 -0.35 3.73e-11 Colorectal cancer; CRC trans rs4591358 0.648 rs16836855 chr2:196386991 C/T cg12742475 chr15:75233485 NA 0.31 6.23 0.32 1.43e-9 Adverse response to chemotherapy (neutropenia/leucopenia) (all antimicrotubule drugs); CRC cis rs11212617 0.875 rs228597 chr11:108107009 G/A cg14761454 chr11:108092087 ATM;NPAT 0.43 6.36 0.33 6.87e-10 Response to metformin in type 2 diabetes (glycemic); CRC cis rs7914558 1.000 rs67908413 chr10:104764989 T/C cg15744005 chr10:104629667 AS3MT -0.32 -6.74 -0.35 6.93e-11 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC trans rs1005277 0.579 rs2505194 chr10:38393881 C/T cg17830980 chr10:43048298 ZNF37B -0.6 -9.91 -0.48 2.01e-20 Extrinsic epigenetic age acceleration; CRC cis rs1005277 0.579 rs2008449 chr10:38414204 A/T cg03665457 chr10:38645376 HSD17B7P2 0.42 6.04 0.32 4.1e-9 Extrinsic epigenetic age acceleration; CRC cis rs6951245 1.000 rs76214082 chr7:1102097 T/A cg22907277 chr7:1156413 C7orf50 0.73 7.68 0.39 1.78e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs6598955 0.724 rs6656716 chr1:26563105 G/A cg00852783 chr1:26633632 UBXN11 0.42 6.86 0.35 3.36e-11 Obesity-related traits; CRC cis rs3768617 0.510 rs20558 chr1:183094547 T/C ch.1.3577855R chr1:183094577 LAMC1 0.89 15.86 0.66 1.84e-42 Fuchs's corneal dystrophy; CRC cis rs7223966 1.000 rs11658329 chr17:61763031 C/G cg23903597 chr17:61704154 MAP3K3 0.42 5.79 0.3 1.65e-8 Hip circumference adjusted for BMI;Body mass index; CRC cis rs7618501 0.602 rs2526743 chr3:50115245 G/A cg24110177 chr3:50126178 RBM5 0.52 8.22 0.41 4.72e-15 Intelligence (multi-trait analysis); CRC cis rs28386778 0.897 rs1877318 chr17:61819960 G/A cg11494091 chr17:61959527 GH2 0.61 10.31 0.49 9.01e-22 Prudent dietary pattern; CRC cis rs4803468 1.000 rs284649 chr19:41926838 C/T cg09537434 chr19:41945824 ATP5SL -0.97 -18.39 -0.71 1.96e-52 Height; CRC cis rs1008375 1.000 rs10012335 chr4:17628630 C/G cg04450456 chr4:17643702 FAM184B 0.35 5.66 0.3 3.35e-8 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs11123170 0.529 rs35606997 chr2:113973350 G/A cg12889195 chr2:113992843 PAX8;LOC440839;LOC654433 0.47 5.74 0.3 2.12e-8 Renal function-related traits (BUN); CRC cis rs12762955 0.561 rs1904671 chr10:1014603 G/A cg26597838 chr10:835615 NA -0.42 -5.68 -0.3 2.9e-8 Response to angiotensin II receptor blocker therapy; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg01799862 chr16:67143802 C16orf70 0.36 6.0 0.31 5.1e-9 Liver disease severity in Alagille syndrome; CRC cis rs362272 0.545 rs2749782 chr4:3339761 A/G cg02993699 chr4:3415135 RGS12 -0.4 -6.58 -0.34 1.87e-10 Serum sulfate level; CRC trans rs4843747 0.518 rs4072777 chr16:88107030 G/A cg26811252 chr16:29126840 RRN3P2 0.61 8.31 0.42 2.62e-15 Menopause (age at onset); CRC cis rs7553864 0.966 rs11161937 chr1:87614510 A/G cg02083836 chr1:87617350 LOC339524 0.38 6.63 0.34 1.35e-10 Smoking behavior; CRC cis rs62229266 0.625 rs62230813 chr21:37403432 C/T cg08632701 chr21:37451849 NA -0.4 -6.19 -0.32 1.8e-9 Mitral valve prolapse; CRC cis rs13191362 1.000 rs67487119 chr6:163102657 A/C cg23758597 chr6:163146217 PARK2 -0.67 -6.71 -0.35 8.57e-11 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs8177179 0.967 rs9869311 chr3:133451613 C/T cg17775713 chr3:133465469 TF 0.37 6.76 0.35 6.35e-11 Iron status biomarkers (transferrin levels); CRC cis rs9783347 1.000 rs4150622 chr11:18365710 A/G cg15585147 chr11:18324498 HPS5 0.43 6.19 0.32 1.8e-9 Pancreatic cancer; CRC cis rs747650 0.884 rs7128325 chr11:47046554 G/A cg19486271 chr11:47235900 DDB2 -0.44 -6.39 -0.33 5.78e-10 Acne (severe); CRC cis rs7726839 0.540 rs12520279 chr5:657291 T/C cg16447950 chr5:562315 NA -0.77 -10.22 -0.49 1.75e-21 Obesity-related traits; CRC cis rs3857536 0.544 rs208453 chr6:66906841 A/T cg07460842 chr6:66804631 NA -0.69 -9.18 -0.45 4.97e-18 Blood trace element (Cu levels); CRC cis rs1192419 0.502 rs6691704 chr1:92056173 T/G cg24006770 chr1:92056542 NA 0.57 9.56 0.47 2.97e-19 Optic disc area;Optic nerve measurement (cup-to-disc ratio); CRC cis rs832540 0.629 rs3309 chr5:56092779 A/T cg18230493 chr5:56204884 C5orf35 0.38 5.66 0.3 3.29e-8 Coronary artery disease; CRC cis rs4563143 0.577 rs73025093 chr19:29254618 T/G cg03161606 chr19:29218774 NA 0.5 6.3 0.33 9.58e-10 Methadone dose in opioid dependence; CRC trans rs60843830 1.000 rs62114505 chr2:242426 A/G cg11347411 chr7:150020925 ACTR3C;LRRC61 0.6 9.25 0.45 2.87e-18 Spherical equivalent (joint analysis main effects and education interaction); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg13948074 chr1:178511686 C1orf220 0.46 6.5 0.34 3.03e-10 Response to antipsychotic treatment; CRC cis rs6951245 0.748 rs79658522 chr7:1095877 A/G cg22907277 chr7:1156413 C7orf50 0.72 7.6 0.39 3.1400000000000003e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs1799949 1.000 rs4793229 chr17:41418334 C/T cg25072359 chr17:41440525 NA -0.46 -6.98 -0.36 1.67e-11 Menopause (age at onset); CRC cis rs10927875 1.000 rs10927875 chr1:16299312 A/G cg24140574 chr1:16342155 HSPB7 0.44 6.1 0.32 3.04e-9 Dilated cardiomyopathy; CRC cis rs1858740 0.509 rs196375 chr3:38422919 C/T cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.57 8.45 0.42 9.44e-16 Schizophrenia; CRC cis rs2882667 0.858 rs11744972 chr5:138428789 A/G cg09476006 chr5:138032270 NA 0.43 6.75 0.35 6.66e-11 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs6570726 0.791 rs1509213 chr6:145783360 G/A cg05347473 chr6:146136440 FBXO30 -0.37 -5.67 -0.3 3.08e-8 Lobe attachment (rater-scored or self-reported); CRC cis rs2708977 0.637 rs654224 chr2:97080123 A/C cg23100626 chr2:96804247 ASTL 0.23 5.98 0.31 5.71e-9 Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes; CRC cis rs2354432 0.505 rs72691009 chr1:146708397 C/T cg25205988 chr1:146714368 CHD1L -1.16 -9.44 -0.46 7.24e-19 Mitochondrial DNA levels; CRC cis rs208520 0.526 rs4710310 chr6:66802808 T/C cg07460842 chr6:66804631 NA -1.19 -25.33 -0.81 2.86e-79 Exhaled nitric oxide output; CRC cis rs10256972 0.553 rs4236381 chr7:1165723 A/C cg03188948 chr7:1209495 NA 0.52 7.31 0.37 2.02e-12 Longevity;Endometriosis; CRC cis rs853679 0.599 rs156743 chr6:27967089 T/C cg06470822 chr6:28175283 NA 0.78 7.31 0.37 2.07e-12 Depression; CRC cis rs8141529 0.871 rs5762877 chr22:29277555 G/A cg15103426 chr22:29168792 CCDC117 0.49 6.63 0.34 1.39e-10 Lymphocyte counts; CRC cis rs6961069 0.745 rs1953298 chr7:80265451 C/T cg04458919 chr7:80252533 CD36 -0.33 -5.86 -0.31 1.13e-8 Platelet count; CRC cis rs7113874 0.524 rs10769921 chr11:8621143 G/A cg17679104 chr11:8615758 STK33 0.34 5.8 0.3 1.59e-8 Body mass index in physically active individuals;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs367615 0.552 rs7720036 chr5:108710699 A/G cg17395555 chr5:108820864 NA -0.36 -6.82 -0.35 4.25e-11 Colorectal cancer (SNP x SNP interaction); CRC cis rs6700896 0.966 rs7516341 chr1:66088143 T/C cg04111102 chr1:66153794 NA 0.33 5.96 0.31 6.62e-9 C-reactive protein;Mean corpuscular volume;Mean corpuscular hemoglobin; CRC trans rs853679 0.546 rs493161 chr6:27850714 A/T cg16898833 chr6:26189333 HIST1H4D 0.74 6.45 0.34 3.89e-10 Depression; CRC cis rs17270561 0.608 rs4711102 chr6:25742075 T/C cg17691542 chr6:26056736 HIST1H1C 0.72 9.24 0.45 3.07e-18 Iron status biomarkers; CRC cis rs796364 1.000 rs1509835 chr2:200814809 C/G cg23649088 chr2:200775458 C2orf69 0.55 5.91 0.31 8.43e-9 Schizophrenia; CRC trans rs7395662 1.000 rs34636547 chr11:48590103 A/G cg21153622 chr11:89784906 NA -0.46 -7.35 -0.38 1.54e-12 HDL cholesterol; CRC cis rs7647973 1.000 rs1009051 chr3:49521549 G/A cg07636037 chr3:49044803 WDR6 0.66 8.09 0.41 1.14e-14 Menarche (age at onset); CRC cis rs1552244 0.935 rs41520445 chr3:10153141 A/C cg10729496 chr3:10149963 C3orf24 -0.55 -7.07 -0.36 9.16e-12 Alzheimer's disease; CRC cis rs35110281 0.840 rs7276633 chr21:45078800 C/T cg01579765 chr21:45077557 HSF2BP -0.38 -7.23 -0.37 3.45e-12 Mean corpuscular volume; CRC cis rs897984 0.762 rs11150601 chr16:30977799 G/A cg00531865 chr16:30841666 NA 0.47 6.78 0.35 5.6e-11 Dementia with Lewy bodies; CRC cis rs11724804 0.532 rs62297079 chr4:879977 G/A cg15105011 chr4:940614 TMEM175 0.57 8.86 0.44 5.27e-17 Primary biliary cholangitis;Limited cutaneous systemic scleroderma; CRC cis rs8060686 0.858 rs2271294 chr16:67902326 A/T cg07125278 chr16:67683757 RLTPR -0.49 -6.77 -0.35 5.9e-11 HDL cholesterol;Metabolic syndrome; CRC cis rs6964587 0.692 rs2299233 chr7:91626953 C/T cg17063962 chr7:91808500 NA -0.62 -10.04 -0.48 7.16e-21 Breast cancer; CRC cis rs13191362 0.935 rs35049401 chr6:162968464 T/G cg06582575 chr6:163149167 PACRG;PARK2 0.82 10.19 0.49 2.3e-21 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs2243480 1.000 rs13310597 chr7:65598540 A/G cg25985355 chr7:65971099 NA -0.51 -5.87 -0.31 1.05e-8 Diabetic kidney disease; CRC cis rs6860806 0.507 rs273917 chr5:131659618 A/G cg09877947 chr5:131593287 PDLIM4 0.45 7.23 0.37 3.5e-12 Breast cancer; CRC cis rs13118159 0.872 rs4974604 chr4:1345798 T/C cg21620606 chr4:1342894 KIAA1530 0.39 6.9 0.36 2.73e-11 Longevity; CRC cis rs2115630 0.645 rs2292463 chr15:85175750 A/G cg12501888 chr15:85177176 SCAND2 -0.45 -7.64 -0.39 2.37e-13 P wave terminal force; CRC cis rs1799949 0.930 rs8176194 chr17:41231221 A/C cg01879757 chr17:41196368 BRCA1 -0.41 -6.05 -0.32 4.01e-9 Menopause (age at onset); CRC cis rs853679 0.517 rs9348797 chr6:28137533 G/C cg12273811 chr6:28175739 NA 0.73 9.16 0.45 5.8e-18 Depression; CRC cis rs2734839 0.537 rs10891549 chr11:113278447 T/C cg14159747 chr11:113255604 NA 0.56 11.37 0.53 1.77e-25 Information processing speed; CRC trans rs1005277 0.579 rs176838 chr10:38371899 A/T cg23533926 chr12:111358616 MYL2 0.51 7.66 0.39 2.13e-13 Extrinsic epigenetic age acceleration; CRC cis rs10479542 0.784 rs6601050 chr5:178986261 C/G cg00080972 chr5:178986291 RUFY1 -0.48 -9.59 -0.47 2.27e-19 Lung cancer; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg04501438 chr7:21466669 SP4 0.37 6.25 0.33 1.25e-9 Liver disease severity in Alagille syndrome; CRC cis rs875971 0.895 rs12698520 chr7:65918707 C/A cg18912574 chr7:65842487 NCRNA00174 0.36 6.12 0.32 2.64e-9 Aortic root size; CRC cis rs4972806 0.814 rs6710370 chr2:177045969 T/C cg09355771 chr2:177043147 NA 0.71 10.98 0.52 4.29e-24 IgG glycosylation; CRC cis rs2019137 0.936 rs2241978 chr2:113954006 A/G cg07594247 chr2:113993304 PAX8;LOC440839;LOC654433 -0.38 -5.6 -0.3 4.42e-8 Lymphocyte counts; CRC trans rs7819412 0.775 rs34094119 chr8:10935898 A/G cg06636001 chr8:8085503 FLJ10661 -0.62 -9.27 -0.46 2.43e-18 Triglycerides; CRC cis rs17376456 0.825 rs17314762 chr5:93231200 C/T cg21475434 chr5:93447410 FAM172A 0.79 7.71 0.39 1.5e-13 Diabetic retinopathy; CRC cis rs9435341 0.965 rs56111229 chr1:107566689 T/A cg11070056 chr1:107600091 PRMT6 0.38 5.62 0.3 4.08e-8 Facial morphology (factor 21, depth of nasal alae); CRC cis rs3091242 0.728 rs706845 chr1:25730713 G/A cg27572855 chr1:25598939 RHD 0.35 6.14 0.32 2.33e-9 Erythrocyte sedimentation rate; CRC cis rs28386778 0.799 rs2955234 chr17:61983601 A/C cg25654072 chr17:61904446 PSMC5;FTSJ3 -0.59 -8.83 -0.44 6.2e-17 Prudent dietary pattern; CRC cis rs7246657 0.943 rs10415024 chr19:37814724 A/G cg23950597 chr19:37808831 NA -0.5 -5.8 -0.3 1.53e-8 Coronary artery calcification; CRC cis rs1996152 0.543 rs9906415 chr17:72389282 A/G cg23221732 chr17:72383708 NA 0.43 7.19 0.37 4.34e-12 Interleukin-12p70 levels; CRC cis rs12410462 1.000 rs75652886 chr1:227654485 G/T cg04117972 chr1:227635322 NA 0.68 7.58 0.39 3.61e-13 Major depressive disorder; CRC trans rs9388451 0.839 rs10457469 chr6:126083658 G/A cg05039488 chr6:79577232 IRAK1BP1 -0.55 -8.38 -0.42 1.58e-15 Brugada syndrome; CRC trans rs2797160 1.000 rs1739377 chr6:126012236 T/C cg05039488 chr6:79577232 IRAK1BP1 0.51 7.59 0.39 3.24e-13 Endometrial cancer; CRC cis rs6964587 0.610 rs4729008 chr7:91457054 G/T cg17063962 chr7:91808500 NA 0.56 8.68 0.43 1.82e-16 Breast cancer; CRC cis rs62064224 0.589 rs756785 chr17:30812845 T/C cg21839984 chr17:30846986 MYO1D -0.34 -5.95 -0.31 6.99e-9 Schizophrenia; CRC cis rs2732480 0.500 rs11168464 chr12:48602115 C/T cg24011408 chr12:48396354 COL2A1 0.44 6.24 0.33 1.38e-9 Hemoglobin concentration;Red blood cell count;Hematocrit; CRC cis rs2380220 0.574 rs9374322 chr6:95998994 G/A cg15832292 chr6:96025679 MANEA 0.56 6.28 0.33 1.08e-9 Behavioural disinhibition (generation interaction); CRC cis rs35110281 0.837 rs7279958 chr21:45016016 C/A cg04455712 chr21:45112962 RRP1B 0.4 7.69 0.39 1.73e-13 Mean corpuscular volume; CRC trans rs57221529 0.713 rs12521091 chr5:590710 G/T cg25482853 chr8:67687455 SGK3 1.19 13.86 0.61 9.81e-35 Lung disease severity in cystic fibrosis; CRC trans rs1728785 0.818 rs1814299 chr16:68581332 G/A cg04657470 chr2:198365150 HSPE1;HSPD1 0.58 7.07 0.36 9.08e-12 Ulcerative colitis; CRC cis rs709400 0.663 rs11628969 chr14:103940911 G/A cg12935359 chr14:103987150 CKB -0.49 -7.93 -0.4 3.42e-14 Body mass index; CRC cis rs4664293 0.632 rs2059697 chr2:160655590 A/G cg08347373 chr2:160653686 CD302 0.45 7.58 0.39 3.48e-13 Monocyte percentage of white cells; CRC cis rs7666738 0.753 rs4699604 chr4:99056353 T/C cg05340658 chr4:99064831 C4orf37 0.58 8.77 0.44 9.53e-17 Colonoscopy-negative controls vs population controls; CRC cis rs9296095 0.796 rs3846855 chr6:33555877 G/A cg14003231 chr6:33640908 ITPR3 0.67 9.48 0.46 5.19e-19 Platelet count; CRC cis rs6951245 1.000 rs76129108 chr7:1089159 G/A cg18402987 chr7:1209562 NA 0.64 6.67 0.35 1.05e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs10979 0.597 rs10782290 chr6:143906340 T/C cg25407410 chr6:143891975 LOC285740 -0.66 -8.66 -0.43 2.2e-16 Hypospadias; CRC cis rs10781543 0.817 rs1128874 chr9:139323424 T/C cg14019695 chr9:139328340 INPP5E 0.41 6.14 0.32 2.38e-9 Monocyte percentage of white cells; CRC cis rs10911363 0.659 rs7518244 chr1:183434807 C/T cg09173681 chr1:183549694 NCF2 -0.73 -10.0 -0.48 9.92e-21 Systemic lupus erythematosus; CRC cis rs16867321 0.588 rs2368175 chr2:181493763 G/C cg23363182 chr2:181467187 NA -0.62 -9.34 -0.46 1.47e-18 Obesity; CRC cis rs2617583 0.967 rs2617594 chr5:1448288 A/G cg07151155 chr5:1473589 LPCAT1 -0.41 -6.25 -0.33 1.25e-9 Breast cancer; CRC cis rs2233152 0.656 rs10405633 chr19:41291703 G/A cg21869046 chr19:41225005 ITPKC 0.43 6.69 0.35 9.61e-11 Kawasaki disease; CRC cis rs853679 0.666 rs200956 chr6:27839746 A/G cg12273811 chr6:28175739 NA 0.56 6.73 0.35 7.64e-11 Depression; CRC cis rs7208859 0.673 rs11080135 chr17:29176481 A/G cg01831904 chr17:28903510 LRRC37B2 -0.55 -5.72 -0.3 2.33e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs7659604 0.539 rs2063165 chr4:122750005 A/G cg19748678 chr4:122722346 EXOSC9 0.65 10.45 0.5 3.03e-22 Type 2 diabetes; CRC cis rs3540 0.618 rs2301832 chr15:91040725 A/T cg22089800 chr15:90895588 ZNF774 -0.56 -9.27 -0.45 2.58e-18 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; CRC trans rs116095464 0.558 rs59284383 chr5:284525 C/G cg00938859 chr5:1591904 SDHAP3 0.71 7.58 0.39 3.45e-13 Breast cancer; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg23663824 chr4:187112650 CYP4V2 0.4 6.89 0.36 2.92e-11 Liver disease severity in Alagille syndrome; CRC cis rs6951245 0.580 rs77101766 chr7:1122438 A/G cg18297960 chr7:1142765 C7orf50 -0.44 -5.86 -0.31 1.14e-8 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs11098499 0.604 rs17051352 chr4:120581427 G/A cg09307838 chr4:120376055 NA 0.67 9.85 0.48 3.04e-20 Corneal astigmatism; CRC cis rs290268 0.874 rs290990 chr9:93561695 A/G cg02608019 chr9:93564028 SYK -0.49 -7.9 -0.4 4.29e-14 Platelet count; CRC cis rs2204008 0.782 rs117824012 chr12:38215517 T/C cg13010199 chr12:38710504 ALG10B 0.45 5.74 0.3 2.1e-8 Bladder cancer; CRC cis rs12142240 0.698 rs17357711 chr1:46829013 A/G cg14993813 chr1:46806288 NSUN4 -0.49 -6.26 -0.33 1.21e-9 Menopause (age at onset); CRC cis rs9584850 0.834 rs3783005 chr13:99111337 A/T cg07423050 chr13:99094983 FARP1 -0.42 -5.99 -0.31 5.4e-9 Neuroticism; CRC cis rs1018836 0.884 rs7823461 chr8:91581075 T/C cg16814680 chr8:91681699 NA -0.74 -11.79 -0.54 5.41e-27 Ejection fraction in Tripanosoma cruzi seropositivity; CRC cis rs9467711 0.591 rs67844427 chr6:25931020 G/A cg08501292 chr6:25962987 TRIM38 1.03 9.09 0.45 9.68e-18 Autism spectrum disorder or schizophrenia; CRC cis rs7618915 0.547 rs13085895 chr3:52678270 G/C cg07507251 chr3:52567010 NT5DC2 0.42 6.04 0.32 4.11e-9 Bipolar disorder; CRC cis rs9399137 0.507 rs13196486 chr6:135283874 C/G cg22676075 chr6:135203613 NA 0.58 8.76 0.43 1.03e-16 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; CRC cis rs1150668 0.830 rs2859365 chr6:28391465 C/T cg06470822 chr6:28175283 NA -0.51 -7.61 -0.39 2.91e-13 Pubertal anthropometrics; CRC cis rs875971 0.597 rs11763224 chr7:65983615 G/T cg05627663 chr7:65219948 SNORA22;CCT6P1 0.58 7.37 0.38 1.37e-12 Aortic root size; CRC cis rs921968 0.643 rs545779 chr2:219336108 A/G cg02176678 chr2:219576539 TTLL4 0.48 8.0 0.4 2.1e-14 Mean corpuscular hemoglobin concentration; CRC trans rs2832077 0.943 rs4816336 chr21:30193519 C/T cg14791747 chr16:20752902 THUMPD1 0.52 6.36 0.33 6.59e-10 Cognitive test performance; CRC cis rs9462027 0.628 rs2815004 chr6:34636268 C/T cg07306190 chr6:34760872 UHRF1BP1 -0.35 -6.32 -0.33 8.5e-10 Systemic lupus erythematosus; CRC cis rs76419734 0.510 rs2216516 chr4:106749857 G/C cg24545054 chr4:106630052 GSTCD;INTS12 -0.56 -6.39 -0.33 5.56e-10 Post bronchodilator FEV1; CRC trans rs62103177 0.525 rs9949598 chr18:77753037 G/A cg05926928 chr17:57297772 GDPD1 -0.68 -8.15 -0.41 7.66e-15 Opioid sensitivity; CRC cis rs5769765 0.773 rs58375955 chr22:50312630 A/G cg04121214 chr22:50244548 NA 0.42 5.89 0.31 9.4e-9 Schizophrenia; CRC cis rs2040771 0.774 rs9604935 chr22:19211665 C/T cg02655711 chr22:19163373 SLC25A1 0.51 8.36 0.42 1.85e-15 Metabolite levels (small molecules and protein measures); CRC cis rs2075371 0.611 rs62462979 chr7:134019379 G/T cg02659138 chr7:134003124 SLC35B4 0.35 5.75 0.3 2.06e-8 Mean platelet volume; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg25964984 chr22:30783371 RNF215 0.45 7.59 0.39 3.41e-13 Liver disease severity in Alagille syndrome; CRC cis rs875971 0.767 rs61348003 chr7:66005934 C/T cg12463550 chr7:65579703 CRCP 0.47 6.39 0.33 5.63e-10 Aortic root size; CRC cis rs2239547 0.522 rs2710345 chr3:52976075 T/C cg11645453 chr3:52864694 ITIH4 -0.52 -9.15 -0.45 5.91e-18 Schizophrenia; CRC cis rs10771431 0.935 rs1117735 chr12:9372728 G/A cg22349387 chr12:9600060 DDX12 -0.37 -5.79 -0.3 1.68e-8 Breast size; CRC cis rs34779708 0.771 rs12098283 chr10:35478115 G/T cg03585969 chr10:35415529 CREM 0.63 8.45 0.42 9.22e-16 Inflammatory bowel disease;Crohn's disease; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg24201296 chr17:37793426 STARD3 0.4 6.21 0.32 1.58e-9 Intelligence (multi-trait analysis); CRC cis rs8180040 1.000 rs1076394 chr3:47322781 G/A cg10298567 chr3:47292165 KIF9 0.44 7.08 0.36 9.03e-12 Colorectal cancer; CRC cis rs875971 0.830 rs809025 chr7:65849819 C/G cg11764359 chr7:65958608 NA 0.59 9.08 0.45 1.06e-17 Aortic root size; CRC trans rs10504229 1.000 rs75037501 chr8:58170136 T/G cg04077850 chr5:125800366 GRAMD3 0.37 6.27 0.33 1.15e-9 Developmental language disorder (linguistic errors); CRC cis rs7712401 0.791 rs6595409 chr5:122113756 G/A cg18764291 chr5:122110994 SNX2 0.43 6.88 0.35 2.96e-11 Mean platelet volume; CRC cis rs8044995 0.563 rs7500163 chr16:68364358 C/G cg05110241 chr16:68378359 PRMT7 -0.74 -7.63 -0.39 2.58e-13 Schizophrenia; CRC cis rs1707322 0.752 rs28812624 chr1:46203736 T/A cg03146154 chr1:46216737 IPP 0.68 9.85 0.48 3.13e-20 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs1552244 1.000 rs6442150 chr3:10122575 T/C cg00166722 chr3:10149974 C3orf24 0.7 9.53 0.46 3.69e-19 Alzheimer's disease; CRC cis rs801193 0.967 rs2707841 chr7:66157020 A/G cg25985355 chr7:65971099 NA -0.32 -5.72 -0.3 2.4e-8 Aortic root size; CRC cis rs2836950 0.520 rs11911087 chr21:40665192 G/A cg17971929 chr21:40555470 PSMG1 -0.56 -8.15 -0.41 7.48e-15 Menarche (age at onset); CRC cis rs10905065 1.000 rs10737013 chr10:5746772 C/G cg25171089 chr10:5708825 ASB13 0.41 5.65 0.3 3.45e-8 Menopause (age at onset); CRC cis rs4927850 1.000 rs10881563 chr3:195750225 A/G cg00031303 chr3:195681400 NA 0.54 7.57 0.39 3.86e-13 Pancreatic cancer; CRC cis rs6933660 0.745 rs3778608 chr6:151738131 A/G cg14416726 chr6:151773293 C6orf211;RMND1 -0.58 -8.85 -0.44 5.64e-17 Menarche (age at onset); CRC cis rs2204008 0.837 rs7301679 chr12:37989629 T/C cg26384229 chr12:38710491 ALG10B -0.64 -9.89 -0.48 2.26e-20 Bladder cancer; CRC cis rs62064224 0.606 rs61390192 chr17:30837447 C/T cg21839984 chr17:30846986 MYO1D -0.49 -7.8 -0.4 8.06e-14 Schizophrenia; CRC cis rs7617773 0.676 rs13060020 chr3:48372646 C/T cg11946769 chr3:48343235 NME6 0.74 9.91 0.48 2.03e-20 Coronary artery disease; CRC cis rs9640161 0.750 rs3800780 chr7:150027284 C/A cg13722127 chr7:150037890 RARRES2 0.5 7.83 0.4 6.62e-14 Blood protein levels;Circulating chemerin levels; CRC cis rs853679 1.000 rs1419183 chr6:28242794 A/C cg03623178 chr6:28175578 NA 0.73 7.35 0.38 1.57e-12 Depression; CRC cis rs12586317 0.620 rs8021414 chr14:35581480 T/A cg16230307 chr14:35515116 FAM177A1 0.78 9.62 0.47 1.82e-19 Psoriasis; CRC cis rs2439831 0.702 rs2467402 chr15:44024490 A/C cg02155558 chr15:43621948 ADAL;LCMT2 -0.59 -7.06 -0.36 9.78e-12 Lung cancer in ever smokers; CRC cis rs9549260 0.564 rs4943804 chr13:41269994 A/G cg21288729 chr13:41239152 FOXO1 0.43 6.63 0.34 1.39e-10 Red blood cell count; CRC cis rs17376456 0.825 rs13171131 chr5:93223028 C/T cg21475434 chr5:93447410 FAM172A 0.76 7.49 0.38 6.51e-13 Diabetic retinopathy; CRC cis rs6500395 1.000 rs1362636 chr16:48712779 T/C cg04672837 chr16:48644449 N4BP1 -0.46 -6.79 -0.35 5.28e-11 Response to tocilizumab in rheumatoid arthritis; CRC cis rs3733585 0.673 rs7376505 chr4:9952744 C/A cg00071950 chr4:10020882 SLC2A9 -0.55 -9.74 -0.47 7.09e-20 Cleft plate (environmental tobacco smoke interaction); CRC cis rs5750830 0.649 rs5757657 chr22:39798429 G/T cg24399712 chr22:39784796 NA -0.53 -11.2 -0.53 7.21e-25 Intelligence (multi-trait analysis); CRC cis rs3806843 0.576 rs246046 chr5:140329264 T/A cg19875535 chr5:140030758 IK 0.39 6.02 0.31 4.67e-9 Depressive symptoms (multi-trait analysis); CRC cis rs853679 0.517 rs6941992 chr6:28106141 T/C cg21251018 chr6:28226885 NKAPL 0.48 6.33 0.33 7.86e-10 Depression; CRC cis rs9488822 0.596 rs6568921 chr6:116373616 C/T cg05304507 chr6:116381966 FRK 0.29 7.41 0.38 1.04e-12 Cholesterol, total;LDL cholesterol; CRC cis rs4285028 0.747 rs3732407 chr3:121416623 G/C cg11130432 chr3:121712080 ILDR1 -0.51 -6.08 -0.32 3.28e-9 Multiple sclerosis; CRC cis rs9611565 0.572 rs139569 chr22:42211141 A/G cg03806693 chr22:41940476 POLR3H -0.66 -9.08 -0.45 9.95e-18 Vitiligo; CRC cis rs1555895 0.656 rs10752020 chr10:840608 G/T cg10556349 chr10:835070 NA 0.38 7.02 0.36 1.28e-11 Survival in rectal cancer; CRC cis rs911119 0.955 rs7265178 chr20:23603382 C/G cg16589663 chr20:23618590 CST3 0.45 6.32 0.33 8.44e-10 Chronic kidney disease; CRC cis rs919433 0.926 rs787997 chr2:198216271 A/G cg03934865 chr2:198174659 NA 0.36 5.81 0.31 1.46e-8 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC cis rs3771570 1.000 rs59496049 chr2:242260756 G/C cg21155796 chr2:242212141 HDLBP 0.58 6.66 0.34 1.18e-10 Prostate cancer; CRC cis rs6502050 0.835 rs62078306 chr17:80085341 A/G cg22110888 chr17:80059540 CCDC57 -0.41 -6.39 -0.33 5.58e-10 Life satisfaction; CRC cis rs17767294 0.612 rs12332927 chr6:27955115 T/C cg06470822 chr6:28175283 NA 0.74 7.97 0.4 2.58e-14 Parkinson's disease; CRC cis rs10504229 0.593 rs17794451 chr8:58019217 C/T cg20607798 chr8:58055168 NA 0.5 5.78 0.3 1.75e-8 Developmental language disorder (linguistic errors); CRC cis rs3087591 0.762 rs7502029 chr17:29590791 T/A cg24425628 chr17:29625626 OMG;NF1 0.84 16.47 0.67 7.33e-45 Hip circumference; CRC cis rs1401999 0.546 rs56889301 chr3:183675315 T/C cg05044414 chr3:183734942 ABCC5 0.38 6.46 0.34 3.67e-10 Anterior chamber depth; CRC cis rs9911578 0.967 rs1267542 chr17:56654690 T/C cg05425664 chr17:57184151 TRIM37 0.52 8.2 0.41 5.31e-15 Intelligence (multi-trait analysis); CRC cis rs3806843 0.966 rs2563264 chr5:140137503 T/G cg16607685 chr5:140181889 PCDHA2;PCDHA1;PCDHA3 0.26 5.99 0.31 5.59e-9 Depressive symptoms (multi-trait analysis); CRC cis rs11971779 0.648 rs6947309 chr7:139035830 C/T cg07862535 chr7:139043722 LUC7L2 0.54 6.87 0.35 3.19e-11 Diisocyanate-induced asthma; CRC cis rs2354432 1.000 rs7514864 chr1:146690102 T/C cg25205988 chr1:146714368 CHD1L 1.15 12.62 0.57 4.76e-30 Mitochondrial DNA levels; CRC cis rs10174077 0.687 rs10172023 chr2:152476028 C/G cg06191203 chr2:152266755 RIF1 -0.57 -7.3 -0.37 2.12e-12 Squamous cell lung carcinoma; CRC cis rs6604026 0.922 rs11586570 chr1:93305371 A/C cg22128645 chr1:93425802 FAM69A -0.39 -5.72 -0.3 2.36e-8 Multiple sclerosis; CRC cis rs6918586 0.658 rs198837 chr6:26113398 A/T cg18357526 chr6:26021779 HIST1H4A 0.49 7.28 0.37 2.43e-12 Schizophrenia; CRC trans rs66759488 0.739 rs10851451 chr15:47608991 A/G cg01684248 chr16:86536239 NA -0.41 -5.99 -0.31 5.6e-9 Lung cancer; CRC cis rs1799949 1.000 rs12516 chr17:41196408 G/A cg25072359 chr17:41440525 NA 0.45 6.86 0.35 3.34e-11 Menopause (age at onset); CRC cis rs9733 0.650 rs11204684 chr1:150608894 A/G cg17724175 chr1:150552817 MCL1 -0.48 -7.6 -0.39 3.18e-13 Tonsillectomy; CRC trans rs2727020 0.533 rs10839195 chr11:48973460 C/T cg21153622 chr11:89784906 NA -0.53 -8.81 -0.44 7.35e-17 Coronary artery disease; CRC cis rs2288912 0.807 rs10423208 chr19:45453656 G/A cg13119609 chr19:45449297 APOC2 0.31 5.89 0.31 9.41e-9 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs6460942 1.000 rs7792759 chr7:12311715 A/G cg20607287 chr7:12443886 VWDE 0.64 6.32 0.33 8.61e-10 Coronary artery disease; CRC cis rs7618915 0.547 rs2289250 chr3:52682946 A/C cg15147215 chr3:52552868 STAB1 0.66 11.0 0.52 3.57e-24 Bipolar disorder; CRC cis rs483180 0.512 rs594400 chr1:120214275 G/T cg19096424 chr1:120255104 PHGDH -0.44 -6.43 -0.33 4.51e-10 Macular telangiectasia type 2; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg03993171 chr6:86388501 SNORD50B;SNORD50A;SNHG5 0.38 6.19 0.32 1.79e-9 Liver disease severity in Alagille syndrome; CRC cis rs12368653 0.591 rs1038914 chr12:58011066 G/A cg12615879 chr12:58013172 SLC26A10 -0.32 -5.9 -0.31 9.08e-9 Multiple sclerosis; CRC cis rs10504229 0.769 rs17804383 chr8:58151830 A/G cg02290350 chr8:58132656 NA -0.51 -6.57 -0.34 1.98e-10 Developmental language disorder (linguistic errors); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg04176437 chr19:18747727 KLHL26 0.42 6.84 0.35 3.97e-11 Liver disease severity in Alagille syndrome; CRC cis rs6502050 0.835 rs7502078 chr17:80131879 C/A cg22110888 chr17:80059540 CCDC57 0.41 6.52 0.34 2.58e-10 Life satisfaction; CRC trans rs5756813 0.727 rs4239889 chr22:38140352 T/G cg19894588 chr14:64061835 NA -0.61 -8.12 -0.41 9.23e-15 Optic cup area;Vertical cup-disc ratio; CRC cis rs4555082 0.834 rs2735819 chr14:105713449 C/T cg06808227 chr14:105710500 BRF1 -0.62 -9.0 -0.44 1.91e-17 Mean platelet volume;Platelet distribution width; CRC cis rs3820068 0.581 rs58425551 chr1:15922518 A/G cg13390004 chr1:15929781 NA 0.49 7.0 0.36 1.45e-11 Systolic blood pressure; CRC cis rs9435341 0.965 rs3108680 chr1:107572997 T/C cg14671364 chr1:107599128 PRMT6 0.46 6.74 0.35 7.1e-11 Facial morphology (factor 21, depth of nasal alae); CRC cis rs2386661 0.826 rs1132293 chr10:5681038 C/T cg26603656 chr10:5671107 NA 0.52 8.76 0.43 1.06e-16 Breast cancer; CRC cis rs1008375 0.966 rs1860591 chr4:17577329 A/G cg16339924 chr4:17578868 LAP3 0.62 8.22 0.41 4.83e-15 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs4665809 0.887 rs6546716 chr2:26263836 A/G cg04944784 chr2:26401820 FAM59B -0.6 -7.73 -0.39 1.31e-13 Gut microbiome composition (summer); CRC cis rs2404602 0.669 rs1875885 chr15:76638081 G/A cg22467129 chr15:76604101 ETFA -0.46 -7.64 -0.39 2.42e-13 Blood metabolite levels; CRC cis rs13191362 0.935 rs35942036 chr6:163163297 C/T cg23758597 chr6:163146217 PARK2 -0.71 -7.2 -0.37 4.25e-12 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs6543140 0.964 rs2141781 chr2:103082906 G/A cg09003973 chr2:102972529 NA 0.41 5.86 0.31 1.12e-8 Blood protein levels; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg10082270 chr16:87425748 FBXO31;MAP1LC3B 0.48 6.53 0.34 2.48e-10 Anxiety disorder; CRC cis rs13108904 0.934 rs4974596 chr4:1301052 A/G cg00684032 chr4:1343700 KIAA1530 0.44 6.3 0.33 9.63e-10 Obesity-related traits; CRC cis rs7589728 0.563 rs12479338 chr2:88444513 C/T cg07952391 chr2:88470173 THNSL2 0.69 7.1 0.36 7.77e-12 Plasma clusterin levels; CRC cis rs6747952 0.899 rs2880132 chr2:239082976 G/A cg17459225 chr2:239074497 NA 0.46 7.85 0.4 5.93e-14 Mean corpuscular hemoglobin concentration; CRC cis rs2019137 0.560 rs10206269 chr2:113990393 C/A cg02675527 chr2:114030824 PAX8;LOC440839 -0.4 -5.89 -0.31 9.45e-9 Lymphocyte counts; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg01586524 chr8:67341819 RRS1 0.45 6.62 0.34 1.5e-10 Intelligence (multi-trait analysis); CRC cis rs208520 0.690 rs851458 chr6:66813279 T/G cg07460842 chr6:66804631 NA -1.09 -15.35 -0.65 1.82e-40 Exhaled nitric oxide output; CRC cis rs798554 0.757 rs1182177 chr7:2874540 C/T cg13628971 chr7:2884303 GNA12 0.54 7.2 0.37 4.04e-12 Height; CRC cis rs28374715 0.635 rs112547435 chr15:41648737 C/G cg18705301 chr15:41695430 NDUFAF1 -0.96 -16.13 -0.66 1.6e-43 Ulcerative colitis; CRC cis rs916888 0.531 rs183211 chr17:44788310 G/A cg15921436 chr17:44337874 NA 0.52 6.57 0.34 2e-10 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs4964805 0.773 rs35746861 chr12:104225284 C/T cg02344784 chr12:104178138 NT5DC3 0.48 6.73 0.35 7.75e-11 Attention deficit hyperactivity disorder; CRC cis rs7827545 1.000 rs62523736 chr8:135560916 A/T cg07299736 chr8:135490787 ZFAT -0.37 -6.0 -0.31 5.28e-9 Hypertension (SNP x SNP interaction); CRC cis rs897984 0.609 rs17839567 chr16:31057945 A/G cg02466173 chr16:30829666 NA -0.6 -9.05 -0.45 1.31e-17 Dementia with Lewy bodies; CRC cis rs6502050 0.805 rs7406682 chr17:80084368 C/T cg02741985 chr17:80059408 CCDC57 -0.44 -7.15 -0.37 5.61e-12 Life satisfaction; CRC cis rs2976388 0.590 rs4736322 chr8:143822208 T/C cg05569086 chr8:143859399 LYNX1 -0.39 -6.43 -0.33 4.47e-10 Urinary tract infection frequency; CRC cis rs6952808 0.609 rs10227517 chr7:1950292 A/T cg21782813 chr7:2030301 MAD1L1 0.4 7.39 0.38 1.23e-12 Bipolar disorder and schizophrenia; CRC cis rs172166 0.516 rs2021826 chr6:28132756 G/A cg21251018 chr6:28226885 NKAPL 0.58 10.15 0.49 3.17e-21 Cardiac Troponin-T levels; CRC cis rs769267 0.895 rs2916073 chr19:19528324 T/G cg02546618 chr19:19431379 KIAA0892;SF4 0.45 6.26 0.33 1.18e-9 Tonsillectomy; CRC cis rs2857891 1.000 rs72845397 chr11:6950903 C/T cg12728517 chr11:6947552 ZNF215 0.57 6.14 0.32 2.38e-9 Response to cytadine analogues (cytosine arabinoside); CRC cis rs57221529 0.709 rs72703090 chr5:598314 C/T cg09021430 chr5:549028 NA -0.72 -8.29 -0.42 2.99e-15 Lung disease severity in cystic fibrosis; CRC cis rs11212617 1.000 rs11212579 chr11:108150664 A/T cg14761454 chr11:108092087 ATM;NPAT 0.42 6.15 0.32 2.28e-9 Response to metformin in type 2 diabetes (glycemic); CRC cis rs7666738 0.830 rs4699594 chr4:98980775 T/C cg17366294 chr4:99064904 C4orf37 0.43 7.33 0.37 1.76e-12 Colonoscopy-negative controls vs population controls; CRC cis rs9291683 0.546 rs12504565 chr4:10045145 G/A cg00071950 chr4:10020882 SLC2A9 0.63 11.19 0.52 7.86e-25 Bone mineral density; CRC cis rs427941 0.517 rs201530 chr7:101777382 A/G cg06246474 chr7:101738831 CUX1 0.36 5.65 0.3 3.49e-8 Plasma omega-3 polyunsaturated fatty acid level (eicosapentaenoic acid); CRC cis rs6743376 0.556 rs1530551 chr2:113817566 C/T cg09040174 chr2:113837401 NA -0.43 -6.32 -0.33 8.56e-10 Inflammatory biomarkers; CRC cis rs2404602 0.583 rs35707798 chr15:76565026 G/C cg03037974 chr15:76606532 NA 0.82 16.47 0.67 6.88e-45 Blood metabolite levels; CRC trans rs6703335 0.870 rs10803142 chr1:243598234 A/G cg07336097 chr8:145670187 NFKBIL2 0.41 6.13 0.32 2.59e-9 Schizophrenia;Schizophrenia, schizoaffective disorder or bipolar disorder; CRC cis rs9787249 0.874 rs12094291 chr1:40226046 G/A cg24920358 chr1:40204285 PPIE 0.57 8.72 0.43 1.36e-16 Blood protein levels; CRC trans rs11168936 0.637 rs10875942 chr12:49670854 A/G cg05384275 chr12:56122970 CD63 -0.4 -6.02 -0.31 4.73e-9 Cancer (pleiotropy); CRC cis rs7945705 0.870 rs4929922 chr11:8975776 A/G cg21881798 chr11:8931708 C11orf17;ST5 -0.65 -9.41 -0.46 8.6e-19 Hemoglobin concentration; CRC cis rs317689 0.702 rs544696 chr12:69749939 T/C cg19645103 chr12:69753606 YEATS4 -0.44 -5.81 -0.3 1.49e-8 Response to diuretic therapy; CRC cis rs7932354 0.502 rs57323109 chr11:47193367 T/G cg19486271 chr11:47235900 DDB2 0.45 6.53 0.34 2.44e-10 Bone mineral density (hip);Bone mineral density; CRC cis rs651907 0.535 rs34161138 chr3:101510388 T/C cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.59 7.84 0.4 6.37e-14 Colorectal cancer; CRC cis rs910316 1.000 rs1043674 chr14:75549370 T/C cg08847533 chr14:75593920 NEK9 0.95 18.79 0.72 5e-54 Height; CRC cis rs344364 0.511 rs2982447 chr16:1947413 C/T cg03013636 chr16:1946785 NA -0.57 -6.97 -0.36 1.79e-11 Glomerular filtration rate in chronic kidney disease; CRC cis rs8058578 1.000 rs6565197 chr16:30706477 T/C cg00531865 chr16:30841666 NA -0.45 -6.13 -0.32 2.58e-9 Multiple myeloma; CRC cis rs7208859 0.623 rs11652358 chr17:29205480 T/C cg13385521 chr17:29058706 SUZ12P 0.69 8.01 0.4 2.02e-14 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs9914988 0.887 rs12947735 chr17:27156866 A/T cg20469991 chr17:27169893 C17orf63 -0.58 -7.08 -0.36 8.54e-12 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs12477438 0.715 rs6724476 chr2:99627316 C/T cg14399236 chr2:99771627 LIPT1;TSGA10 -0.6 -8.22 -0.41 4.6e-15 Chronic sinus infection; CRC trans rs7324845 0.688 rs1980830 chr13:46712587 C/T cg17840719 chr5:178368253 ZNF454 -0.43 -6.0 -0.31 5.08e-9 Non-alcoholic fatty liver disease histology (other); CRC cis rs7586879 0.551 rs7565460 chr2:25130073 C/T cg04586622 chr2:25135609 ADCY3 -0.54 -10.1 -0.49 4.46e-21 Body mass index; CRC cis rs35146811 0.807 rs6953441 chr7:99617067 G/A cg03265037 chr7:99691720 MIR25;MCM7;MIR106B;MIR93 0.43 5.64 0.3 3.6e-8 Coronary artery disease; CRC cis rs7829975 0.514 rs2976929 chr8:8258712 T/C cg14979609 chr8:8086686 FLJ10661 -0.37 -5.89 -0.31 9.46e-9 Mood instability; CRC cis rs853679 0.517 rs9357063 chr6:28060005 G/A cg15786705 chr6:28176104 NA 0.76 9.61 0.47 1.97e-19 Depression; CRC cis rs4713118 0.869 rs4713121 chr6:27722064 T/C cg06470822 chr6:28175283 NA 0.79 10.14 0.49 3.45e-21 Parkinson's disease; CRC cis rs1552244 1.000 rs35993975 chr3:10067794 A/G cg13047869 chr3:10149882 C3orf24 0.56 6.82 0.35 4.31e-11 Alzheimer's disease; CRC cis rs6460942 0.778 rs17444259 chr7:12462428 C/T cg20607287 chr7:12443886 VWDE -0.59 -7.29 -0.37 2.36e-12 Coronary artery disease; CRC cis rs2522056 0.808 rs17771891 chr5:131744202 A/G cg20512303 chr5:131592959 PDLIM4 0.39 6.03 0.32 4.36e-9 Lymphocyte counts;Fibrinogen; CRC cis rs1577917 0.916 rs4142546 chr6:86505311 G/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.5 -6.56 -0.34 2.03e-10 Response to antipsychotic treatment; CRC cis rs7169223 0.615 rs8038189 chr15:79099026 G/C cg22753661 chr15:79092743 ADAMTS7 -0.47 -5.72 -0.3 2.45e-8 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; CRC cis rs1348850 0.874 rs2166558 chr2:178373652 G/T cg22681709 chr2:178499509 PDE11A -0.37 -6.76 -0.35 6.25e-11 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs3806843 0.576 rs246032 chr5:140332547 C/A cg19875535 chr5:140030758 IK 0.4 6.12 0.32 2.64e-9 Depressive symptoms (multi-trait analysis); CRC cis rs977987 0.778 rs4887821 chr16:75398574 G/A cg03315344 chr16:75512273 CHST6 0.54 9.07 0.45 1.13e-17 Dupuytren's disease; CRC cis rs9300255 0.770 rs12299125 chr12:123862447 C/T cg00376283 chr12:123451042 ABCB9 -0.51 -6.54 -0.34 2.32e-10 Neutrophil percentage of white cells; CRC cis rs67340775 0.541 rs200968 chr6:27859568 T/C cg15786705 chr6:28176104 NA 0.56 5.67 0.3 3.09e-8 Lung cancer in ever smokers; CRC cis rs9534288 0.740 rs7989892 chr13:46630641 C/T cg15192986 chr13:46630673 CPB2 -0.77 -10.45 -0.5 2.92e-22 Blood protein levels; CRC cis rs10751667 0.666 rs10902241 chr11:949129 G/A cg06064525 chr11:970664 AP2A2 -0.31 -6.2 -0.32 1.68e-9 Alzheimer's disease (late onset); CRC cis rs25422 0.938 rs9489443 chr6:118886163 T/A cg18833306 chr6:118973337 C6orf204 0.45 5.89 0.31 9.35e-9 Renal cell carcinoma; CRC cis rs992157 0.560 rs7578940 chr2:219083318 G/T cg04880052 chr2:219191631 PNKD -0.42 -6.71 -0.35 8.69e-11 Colorectal cancer; CRC trans rs2303319 0.504 rs56407015 chr2:162455625 G/A cg14875682 chr5:52083620 ITGA1;PELO -0.72 -5.97 -0.31 6.06e-9 Cognitive function; CRC cis rs12410462 1.000 rs80168344 chr1:227655804 C/T cg04117972 chr1:227635322 NA 0.67 7.49 0.38 6.26e-13 Major depressive disorder; CRC trans rs875971 0.545 rs73152714 chr7:65999628 G/A cg02869306 chr7:64672164 INTS4L1 -0.44 -6.39 -0.33 5.74e-10 Aortic root size; CRC cis rs10751667 0.600 rs14346 chr11:1011829 T/C cg23136738 chr11:925521 AP2A2 -0.38 -5.95 -0.31 6.74e-9 Alzheimer's disease (late onset); CRC cis rs9916302 0.653 rs11657058 chr17:37699378 T/G cg00129232 chr17:37814104 STARD3 -0.59 -7.28 -0.37 2.45e-12 Glomerular filtration rate (creatinine); CRC cis rs9910055 1.000 rs2071167 chr17:42287519 A/G cg09913183 chr17:42254507 C17orf65;ASB16 -0.51 -7.53 -0.38 4.82e-13 Total body bone mineral density; CRC cis rs3540 0.574 rs2657946 chr15:90967513 G/C cg22089800 chr15:90895588 ZNF774 0.57 9.47 0.46 5.71e-19 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; CRC cis rs10760158 0.832 rs4837826 chr9:124024129 C/A cg14417974 chr9:124058376 GSN -0.34 -5.68 -0.3 2.96e-8 Pulse pressure; CRC cis rs3091242 0.933 rs11249250 chr1:25767609 G/A cg23205692 chr1:25664452 TMEM50A 0.41 5.81 0.31 1.47e-8 Erythrocyte sedimentation rate; CRC cis rs6582630 0.615 rs11182380 chr12:38511735 G/T cg26384229 chr12:38710491 ALG10B -0.52 -7.49 -0.38 6.57e-13 Drug-induced liver injury (flucloxacillin); CRC cis rs7591163 0.959 rs10933217 chr2:228716226 T/C cg14329157 chr2:228736135 WDR69 -0.48 -6.59 -0.34 1.77e-10 Blood pressure; CRC cis rs755249 0.567 rs2018212 chr1:39905588 T/C cg18385671 chr1:39797026 MACF1 -0.41 -5.84 -0.31 1.28e-8 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs597539 0.580 rs7935851 chr11:68731122 A/G cg21963583 chr11:68658836 MRPL21 0.55 9.69 0.47 1.08e-19 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC trans rs7615952 0.543 rs4645102 chr3:125424441 A/G cg07211511 chr3:129823064 LOC729375 -0.61 -8.51 -0.42 6.07e-16 Blood pressure (smoking interaction); CRC cis rs1008375 0.932 rs13127157 chr4:17618049 A/G cg16339924 chr4:17578868 LAP3 -0.6 -7.59 -0.39 3.39e-13 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs4072705 0.646 rs10120967 chr9:127244134 C/T cg13476313 chr9:127244764 NR5A1 0.29 5.87 0.31 1.05e-8 Menarche (age at onset); CRC cis rs9322193 0.923 rs9968911 chr6:149978555 A/T cg05861140 chr6:150128134 PCMT1 -0.36 -5.81 -0.3 1.51e-8 Lung cancer; CRC cis rs9463078 0.764 rs6458415 chr6:44881592 G/C cg25276700 chr6:44698697 NA -0.28 -6.84 -0.35 3.97e-11 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; CRC cis rs4072705 0.646 rs915032 chr9:127245682 G/C cg13476313 chr9:127244764 NR5A1 0.28 5.7 0.3 2.66e-8 Menarche (age at onset); CRC cis rs7258465 1.000 rs28572537 chr19:18552208 C/T cg10790698 chr19:18539756 SSBP4 -0.43 -8.02 -0.4 1.92e-14 Breast cancer; CRC trans rs564309 1.000 rs503203 chr1:228602660 G/C cg24066601 chr6:26271455 HIST1H3G 0.6 6.27 0.33 1.15e-9 Hip circumference (psychosocial stress interaction); CRC cis rs8177253 0.761 rs1830084 chr3:133508464 A/T cg12373951 chr3:133503437 NA -0.27 -7.03 -0.36 1.23e-11 Iron status biomarkers; CRC cis rs1046896 0.553 rs9893885 chr17:80837107 C/T cg02711726 chr17:80685570 FN3KRP -0.53 -7.12 -0.37 6.71e-12 Glycated hemoglobin levels; CRC cis rs9359856 0.600 rs11961825 chr6:90482250 T/A cg13799429 chr6:90582589 CASP8AP2 -0.75 -7.61 -0.39 2.88e-13 Bipolar disorder; CRC cis rs12519773 0.555 rs1845840 chr5:92388210 G/A cg18783429 chr5:92414398 NA -0.35 -7.4 -0.38 1.16e-12 Migraine; CRC cis rs2243480 1.000 rs13247184 chr7:65358928 A/G cg18252515 chr7:66147081 NA -1.17 -13.25 -0.59 2.03e-32 Diabetic kidney disease; CRC cis rs10946940 0.965 rs6910838 chr6:27515519 A/C cg21251018 chr6:28226885 NKAPL -0.4 -6.16 -0.32 2.09e-9 Systemic lupus erythematosus; CRC cis rs7945705 0.935 rs10769971 chr11:8925276 C/T cg21881798 chr11:8931708 C11orf17;ST5 0.67 10.21 0.49 1.99e-21 Hemoglobin concentration; CRC cis rs9894429 0.869 rs9748184 chr17:79596280 A/G cg18240062 chr17:79603768 NPLOC4 0.56 9.43 0.46 7.75e-19 Eye color traits; CRC cis rs4481887 1.000 rs4508046 chr1:248488988 T/C cg13385794 chr1:248469461 NA 0.39 6.68 0.35 1.01e-10 Common traits (Other); CRC cis rs597539 0.652 rs546382 chr11:68704264 C/T cg06028808 chr11:68637592 NA 0.38 6.01 0.31 5.01e-9 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC trans rs7395662 0.895 rs11039869 chr11:48622312 C/G cg21153622 chr11:89784906 NA -0.45 -7.22 -0.37 3.57e-12 HDL cholesterol; CRC cis rs10927875 0.541 rs1048237 chr1:16341733 T/C cg24140574 chr1:16342155 HSPB7 0.47 6.67 0.34 1.12e-10 Dilated cardiomyopathy; CRC cis rs58688157 0.705 rs12419694 chr11:598033 C/T cg07212818 chr11:638076 DRD4 -0.45 -5.99 -0.31 5.57e-9 Systemic lupus erythematosus; CRC cis rs6598163 0.517 rs11246827 chr12:132296423 G/A cg07389463 chr12:132296394 NA 0.43 6.58 0.34 1.9e-10 Migraine; CRC cis rs9322193 0.923 rs12195866 chr6:150014470 A/G cg00933542 chr6:150070202 PCMT1 0.28 5.65 0.3 3.5e-8 Lung cancer; CRC cis rs11098499 0.954 rs35063680 chr4:120387102 T/C cg09307838 chr4:120376055 NA 0.71 10.92 0.52 6.75e-24 Corneal astigmatism; CRC cis rs769267 0.930 rs892021 chr19:19613480 T/C cg02546618 chr19:19431379 KIAA0892;SF4 0.44 6.08 0.32 3.33e-9 Tonsillectomy; CRC cis rs8072100 0.713 rs4968257 chr17:45430534 A/G cg25173405 chr17:45401733 C17orf57 -0.47 -7.24 -0.37 3.22e-12 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC trans rs2303319 0.504 rs58622044 chr2:162596287 A/G cg03124313 chr19:36036028 GAPDHS;TMEM147 -0.67 -6.0 -0.31 5.21e-9 Cognitive function; CRC cis rs2404602 0.716 rs66754747 chr15:76828568 G/A cg22467129 chr15:76604101 ETFA -0.4 -6.53 -0.34 2.43e-10 Blood metabolite levels; CRC cis rs1953600 1.000 rs1953600 chr10:81911725 A/G cg00277334 chr10:82204260 NA 0.37 6.1 0.32 2.96e-9 Sarcoidosis; CRC cis rs9649213 0.593 rs7796611 chr7:97908223 A/G cg24562669 chr7:97807699 LMTK2 0.46 7.78 0.39 9.24e-14 Prostate cancer (SNP x SNP interaction); CRC cis rs3858526 0.755 rs10769368 chr11:5962084 C/T cg13902645 chr11:5959945 NA 0.46 6.45 0.33 4.09e-10 DNA methylation (variation); CRC cis rs9814567 1.000 rs9827987 chr3:134272621 A/G cg06109529 chr3:134205091 CEP63;ANAPC13 -0.82 -12.36 -0.56 4.36e-29 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs1003719 0.707 rs9976360 chr21:38587860 C/T cg10648535 chr21:38446584 PIGP;TTC3 -0.45 -6.23 -0.32 1.41e-9 Eye color traits; CRC trans rs1005277 0.579 rs2474568 chr10:38383147 A/T cg23533926 chr12:111358616 MYL2 -0.52 -7.89 -0.4 4.56e-14 Extrinsic epigenetic age acceleration; CRC cis rs12142240 0.698 rs57267378 chr1:46816644 A/G cg14993813 chr1:46806288 NSUN4 -0.5 -6.4 -0.33 5.38e-10 Menopause (age at onset); CRC cis rs735396 1.000 rs2464195 chr12:121435475 G/A cg02403541 chr12:121454288 C12orf43 0.44 6.67 0.34 1.11e-10 N-glycan levels; CRC cis rs780096 0.587 rs4665969 chr2:27574953 C/T cg24768116 chr2:27665128 KRTCAP3 0.32 6.85 0.35 3.74e-11 Total body bone mineral density; CRC cis rs8060686 0.920 rs111315946 chr16:67889793 G/C cg19582491 chr16:67682965 RLTPR -0.56 -6.71 -0.35 8.48e-11 HDL cholesterol;Metabolic syndrome; CRC cis rs6693567 0.565 rs4926395 chr1:150405298 T/C cg15654264 chr1:150340011 RPRD2 0.38 5.95 0.31 7.04e-9 Migraine; CRC cis rs875971 0.825 rs1000464 chr7:65777909 G/C cg11764359 chr7:65958608 NA -0.61 -9.41 -0.46 8.68e-19 Aortic root size; CRC cis rs10504229 1.000 rs56168206 chr8:58184485 G/A cg02725872 chr8:58115012 NA -0.38 -6.43 -0.33 4.44e-10 Developmental language disorder (linguistic errors); CRC cis rs2839186 0.933 rs4818832 chr21:47708634 C/T cg02776659 chr21:47717406 C21orf57 -0.34 -5.62 -0.3 4.13e-8 Testicular germ cell tumor; CRC cis rs908922 0.847 rs499697 chr1:152493154 A/G cg23254163 chr1:152506842 NA -0.41 -6.89 -0.36 2.85e-11 Hair morphology; CRC cis rs6540556 0.769 rs6679405 chr1:209926468 A/C cg05527609 chr1:210001259 C1orf107 -0.47 -5.6 -0.3 4.43e-8 Red blood cell count; CRC cis rs7713065 0.531 rs2522051 chr5:131797578 C/T cg02033258 chr5:131593261 PDLIM4 0.34 6.31 0.33 8.88e-10 Lung function (FEV1/FVC); CRC cis rs7666738 0.791 rs1405766 chr4:98965389 T/C cg05340658 chr4:99064831 C4orf37 0.61 9.45 0.46 6.55e-19 Colonoscopy-negative controls vs population controls; CRC cis rs8014204 0.836 rs12888998 chr14:75292662 G/T cg03030879 chr14:75389066 RPS6KL1 -0.51 -8.12 -0.41 9.45e-15 Caffeine consumption; CRC cis rs35110281 0.805 rs2838318 chr21:44991825 G/A cg01579765 chr21:45077557 HSF2BP -0.34 -6.29 -0.33 1.01e-9 Mean corpuscular volume; CRC cis rs812925 0.537 rs10208769 chr2:61605614 A/T cg10580144 chr2:61372316 C2orf74 -0.33 -7.44 -0.38 8.75e-13 Immature fraction of reticulocytes; CRC cis rs1223397 1.000 rs1232392 chr6:13272671 C/G cg07912922 chr6:13274314 PHACTR1 0.52 6.37 0.33 6.5e-10 Blood pressure; CRC cis rs11997175 0.549 rs4357253 chr8:33652458 G/A ch.8.33884649F chr8:33765107 NA 0.48 7.68 0.39 1.86e-13 Body mass index; CRC cis rs1448094 0.511 rs61930581 chr12:86157241 G/A cg02569458 chr12:86230093 RASSF9 0.51 8.43 0.42 1.13e-15 Major depressive disorder; CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg12868349 chr11:71639594 RNF121;LOC100133315 -0.56 -6.96 -0.36 1.86e-11 Diisocyanate-induced asthma; CRC cis rs990171 1.000 rs2041756 chr2:103049910 C/T cg03938978 chr2:103052716 IL18RAP -0.47 -5.99 -0.31 5.59e-9 Lymphocyte counts; CRC cis rs13118159 0.872 rs1882105 chr4:1345956 T/C cg19318889 chr4:1322082 MAEA 0.51 7.37 0.38 1.41e-12 Longevity; CRC trans rs10506458 1.000 rs73128794 chr12:63445313 C/T cg22491629 chr6:157744540 C6orf35 -0.74 -8.87 -0.44 4.63e-17 Hemostatic factors and hematological phenotypes; CRC trans rs6708331 0.517 rs7579922 chr2:70361913 A/G cg06926377 chr15:40443853 NA 0.41 5.98 0.31 5.85e-9 Obesity-related traits; CRC cis rs9868809 0.505 rs9877685 chr3:48748588 C/T cg07636037 chr3:49044803 WDR6 -0.68 -6.53 -0.34 2.57e-10 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; CRC cis rs10751667 0.666 rs6597966 chr11:950750 T/C cg01483505 chr11:975446 AP2A2 0.45 7.39 0.38 1.21e-12 Alzheimer's disease (late onset); CRC cis rs9649465 0.967 rs13239184 chr7:123314618 G/T cg03229431 chr7:123269106 ASB15 -0.37 -5.77 -0.3 1.81e-8 Migraine; CRC cis rs853679 0.517 rs1947862 chr6:28105196 C/T cg12963246 chr6:28129442 ZNF389 0.49 5.77 0.3 1.83e-8 Depression; CRC trans rs4308415 0.753 rs1603179 chr4:67805347 A/C cg19648955 chr2:177134095 MTX2 -0.42 -6.15 -0.32 2.19e-9 Educational attainment (years of education); CRC cis rs3741151 1.000 rs74749711 chr11:73052839 A/T cg17517138 chr11:73019481 ARHGEF17 0.66 6.88 0.35 3.11e-11 GIP levels in response to oral glucose tolerance test (120 minutes); CRC cis rs2237234 0.542 rs7755997 chr6:26483048 G/A cg09904177 chr6:26538194 HMGN4 0.44 5.91 0.31 8.57e-9 Autism spectrum disorder or schizophrenia; CRC cis rs3091242 0.804 rs631133 chr1:25724146 T/C cg20684491 chr1:25596433 NA 0.4 6.87 0.35 3.31e-11 Erythrocyte sedimentation rate; CRC cis rs4253772 0.550 rs739164 chr22:46684558 C/T cg09491104 chr22:46646882 C22orf40 0.39 5.85 0.31 1.16e-8 LDL cholesterol;Cholesterol, total; CRC cis rs12586317 0.547 rs28589276 chr14:35478865 A/G cg05294307 chr14:35346193 BAZ1A -0.71 -7.76 -0.39 1.11e-13 Psoriasis; CRC trans rs11165623 0.543 rs60982887 chr1:96989155 T/G cg10631902 chr5:14652156 NA -0.4 -6.99 -0.36 1.51e-11 Hip circumference;Waist circumference; CRC cis rs2668423 0.502 rs7254913 chr19:1388320 A/G cg02639931 chr19:1387894 NDUFS7 0.79 16.55 0.67 3.37e-45 Nonalcoholic fatty liver disease; CRC cis rs1797081 0.840 rs10904820 chr10:16848473 A/G cg23933602 chr10:16859644 RSU1 0.93 17.25 0.69 6.18e-48 Platelet distribution width; CRC cis rs9858542 1.000 rs1131095 chr3:49714225 T/C cg00383909 chr3:49044727 WDR6 0.46 5.63 0.3 3.86e-8 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs4713118 0.505 rs276371 chr6:27910708 A/T cg06470822 chr6:28175283 NA 0.59 8.16 0.41 7.29e-15 Parkinson's disease; CRC cis rs7131987 0.675 rs2194515 chr12:29550383 T/C cg09582351 chr12:29534625 ERGIC2 0.33 7.17 0.37 5.12e-12 QT interval; CRC cis rs8114671 0.662 rs3761143 chr20:33545745 C/T cg07148914 chr20:33460835 GGT7 0.38 6.01 0.31 5.05e-9 Height; CRC cis rs4722166 0.598 rs4722171 chr7:22785717 A/G cg05472934 chr7:22766657 IL6 0.77 12.55 0.57 8.65e-30 Lung cancer; CRC cis rs3018066 0.867 rs13138528 chr4:107154273 T/C cg01869342 chr4:106983673 TBCK -0.36 -5.63 -0.3 3.82e-8 Cancer; CRC trans rs10411161 0.748 rs17835306 chr19:52385266 G/A cg22319618 chr22:45562946 NUP50 -0.69 -5.98 -0.31 5.79e-9 Breast cancer; CRC cis rs9903692 0.954 rs4794441 chr17:46176456 C/T cg21215337 chr17:46176117 CBX1 -0.43 -7.95 -0.4 2.95e-14 Pulse pressure; CRC cis rs2282802 0.685 rs12717951 chr5:139589309 A/G cg26211634 chr5:139558579 C5orf32 0.44 7.84 0.4 6.32e-14 Intelligence (multi-trait analysis); CRC cis rs2880765 0.743 rs6497191 chr15:86011501 T/C cg17133734 chr15:86042851 AKAP13 0.41 6.43 0.33 4.42e-10 Coronary artery disease; CRC cis rs9527 0.615 rs1556960 chr10:104726673 A/G cg04362960 chr10:104952993 NT5C2 0.6 8.47 0.42 8.43e-16 Arsenic metabolism; CRC cis rs6456156 0.846 rs204293 chr6:167514481 T/C cg07513332 chr6:167530253 CCR6 0.42 7.27 0.37 2.57e-12 Primary biliary cholangitis; CRC cis rs9910055 0.540 rs609292 chr17:42180436 G/A cg10896456 chr17:42255109 ASB16;C17orf65 -0.42 -6.6 -0.34 1.6e-10 Total body bone mineral density; CRC cis rs2739330 0.587 rs4820571 chr22:24242973 A/G cg16132339 chr22:24313637 DDTL;DDT 0.45 6.67 0.34 1.11e-10 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs2075371 0.932 rs2544215 chr7:133987896 T/C cg11752832 chr7:134001865 SLC35B4 0.49 7.68 0.39 1.79e-13 Mean platelet volume; CRC cis rs501120 0.584 rs2664856 chr10:44702967 G/T cg09554077 chr10:44749378 NA 0.67 7.44 0.38 8.88e-13 Coronary artery disease;Coronary heart disease; CRC cis rs4925386 1.000 rs4925386 chr20:60921044 C/T cg24112000 chr20:60950667 NA -0.49 -8.73 -0.43 1.29e-16 Colorectal cancer;Colorectal cancer (SNP x SNP interaction); CRC cis rs589691 0.502 rs487662 chr11:64481880 G/A cg06522879 chr11:64358276 SLC22A12 -0.44 -6.44 -0.33 4.27e-10 Urate levels; CRC trans rs6693295 0.729 rs10399630 chr1:246212561 A/T cg03680032 chr11:94965610 SESN3 0.5 6.16 0.32 2.09e-9 Migraine - clinic-based;Migraine with aura; CRC cis rs34779708 0.733 rs3936503 chr10:35549257 A/G cg03585969 chr10:35415529 CREM -0.53 -7.18 -0.37 4.61e-12 Inflammatory bowel disease;Crohn's disease; CRC cis rs4664308 1.000 rs16844715 chr2:160915106 A/G cg03641300 chr2:160917029 PLA2R1 0.75 12.75 0.58 1.51e-30 Idiopathic membranous nephropathy; CRC cis rs9814567 1.000 rs9829092 chr3:134229866 C/G cg06109529 chr3:134205091 CEP63;ANAPC13 -0.82 -12.27 -0.56 9.51e-29 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs9584850 0.834 rs2031239 chr13:99111560 C/T cg20750642 chr13:99100586 FARP1 -0.41 -5.84 -0.31 1.23e-8 Neuroticism; CRC cis rs3087591 0.922 rs2905805 chr17:29502856 C/A cg24425628 chr17:29625626 OMG;NF1 0.86 16.15 0.66 1.31e-43 Hip circumference; CRC cis rs13217239 0.646 rs12527111 chr6:27006475 C/T cg12292205 chr6:26970375 C6orf41 0.55 9.14 0.45 6.4e-18 Schizophrenia; CRC cis rs875971 0.545 rs4718335 chr7:65804606 C/T cg11764359 chr7:65958608 NA 0.46 5.77 0.3 1.83e-8 Aortic root size; CRC cis rs9826463 0.582 rs11720762 chr3:142140511 T/G cg20824294 chr3:142316082 PLS1 0.38 6.05 0.32 3.87e-9 QRS duration in Tripanosoma cruzi seropositivity; CRC cis rs9916302 0.904 rs10432031 chr17:37397852 G/A cg00129232 chr17:37814104 STARD3 -0.55 -8.02 -0.4 1.89e-14 Glomerular filtration rate (creatinine); CRC cis rs7937682 0.889 rs567859 chr11:111486738 A/G cg19812747 chr11:111475976 SIK2 -0.59 -10.14 -0.49 3.31e-21 Primary sclerosing cholangitis; CRC cis rs834811 0.829 rs6980107 chr7:135900757 C/T cg01726295 chr7:135938950 NA -0.48 -8.53 -0.43 5.6e-16 Post-traumatic stress disorder; CRC cis rs4973397 0.765 rs10445830 chr2:232263973 C/T cg13347044 chr2:232276743 NA 0.44 6.25 0.33 1.24e-9 Anti-saccade response; CRC cis rs9326248 1.000 rs4938354 chr11:117051165 A/G cg26566898 chr11:117069891 TAGLN 0.44 9.75 0.47 6.67e-20 Blood protein levels; CRC cis rs13108904 0.967 rs1316419 chr4:1293997 C/T cg16405210 chr4:1374714 KIAA1530 -0.44 -5.96 -0.31 6.46e-9 Obesity-related traits; CRC cis rs4555082 0.957 rs2816628 chr14:105736134 T/G cg18132624 chr14:105716052 BTBD6;BRF1 -0.36 -5.99 -0.31 5.47e-9 Mean platelet volume;Platelet distribution width; CRC trans rs12554020 0.681 rs78759589 chr9:96171800 G/A cg23291280 chr19:31847970 NA -0.68 -6.24 -0.33 1.36e-9 Schizophrenia; CRC cis rs11212617 0.967 rs625120 chr11:108095220 A/G cg14761454 chr11:108092087 ATM;NPAT 0.43 6.32 0.33 8.29e-10 Response to metformin in type 2 diabetes (glycemic); CRC cis rs12701220 0.744 rs35588238 chr7:1012006 G/A cg26769984 chr7:1090371 C7orf50 0.51 7.33 0.37 1.82e-12 Bronchopulmonary dysplasia; CRC cis rs651907 0.535 rs11716558 chr3:101528481 T/C cg11279151 chr3:101281821 RG9MTD1 -0.53 -7.09 -0.36 8.3e-12 Colorectal cancer; CRC cis rs67311347 0.866 rs2371183 chr3:40334247 C/T cg09455208 chr3:40491958 NA -0.3 -5.84 -0.31 1.27e-8 Renal cell carcinoma; CRC cis rs2976388 0.609 rs2717605 chr8:143801015 T/G cg15511327 chr8:143859410 LYNX1 0.39 6.92 0.36 2.4e-11 Urinary tract infection frequency; CRC cis rs4076764 0.881 rs10917758 chr1:163430652 G/A cg24596788 chr1:163392923 NA -0.57 -8.89 -0.44 4.16e-17 Motion sickness; CRC cis rs10242455 0.702 rs73405247 chr7:99159174 C/G cg18809830 chr7:99032528 PTCD1 -1.21 -8.72 -0.43 1.36e-16 Blood metabolite levels; CRC cis rs3806843 0.900 rs2563287 chr5:140124786 C/T cg19875535 chr5:140030758 IK 0.53 8.58 0.43 3.8e-16 Depressive symptoms (multi-trait analysis); CRC cis rs375066 0.599 rs2356439 chr19:44353131 A/G cg19542119 chr19:44331823 ZNF283 0.4 5.61 0.3 4.24e-8 Breast cancer; CRC cis rs12900413 0.687 rs12902786 chr15:90304376 G/A cg24249390 chr15:90295951 MESP1 -0.55 -8.46 -0.42 8.59e-16 Coronary artery aneurysm in Kawasaki disease; CRC cis rs2050392 0.928 rs6481677 chr10:30701816 A/G cg18806716 chr10:30721971 MAP3K8 -0.46 -7.15 -0.37 5.66e-12 Inflammatory bowel disease; CRC trans rs7647973 0.626 rs4855845 chr3:49687043 T/C cg21665057 chr3:196295764 WDR53;FBXO45 -0.63 -6.99 -0.36 1.49e-11 Menarche (age at onset); CRC cis rs10504229 1.000 rs67344620 chr8:58187537 C/A cg24829409 chr8:58192753 C8orf71 -0.68 -11.34 -0.53 2.27e-25 Developmental language disorder (linguistic errors); CRC cis rs3740540 0.507 rs10794161 chr10:126291327 C/A cg04949429 chr10:126290192 LHPP 0.42 6.23 0.32 1.45e-9 Obesity-related traits;Acute lymphoblastic leukemia (childhood); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg08437167 chr3:9885801 RPUSD3 0.41 6.11 0.32 2.79e-9 Intelligence (multi-trait analysis); CRC cis rs992157 0.717 rs11692780 chr2:219149163 A/G cg00012203 chr2:219082015 ARPC2 -0.47 -7.0 -0.36 1.42e-11 Colorectal cancer; CRC trans rs1728785 1.000 rs7205960 chr16:68565604 G/C cg04657470 chr2:198365150 HSPE1;HSPD1 0.58 6.85 0.35 3.68e-11 Ulcerative colitis; CRC cis rs711245 0.573 rs3770796 chr2:36799515 T/C cg09467607 chr2:36825704 FEZ2 0.53 8.36 0.42 1.77e-15 Height; CRC cis rs7095944 0.584 rs4962691 chr10:126424137 C/T cg08799069 chr10:126477246 METTL10 -0.45 -6.93 -0.36 2.29e-11 Asthma; CRC cis rs5758659 0.623 rs133328 chr22:42408079 T/C cg04733989 chr22:42467013 NAGA 0.4 5.62 0.3 4.12e-8 Cognitive function; CRC cis rs9905704 0.647 rs11079367 chr17:57009024 A/G cg12560992 chr17:57184187 TRIM37 0.62 9.42 0.46 8.4e-19 Testicular germ cell tumor; CRC cis rs6570726 0.935 rs414646 chr6:145831685 T/C cg23711669 chr6:146136114 FBXO30 0.68 12.16 0.56 2.33e-28 Lobe attachment (rater-scored or self-reported); CRC trans rs2727020 0.523 rs4115783 chr11:49556026 G/A cg15704280 chr7:45808275 SEPT13 0.78 10.48 0.5 2.33e-22 Coronary artery disease; CRC cis rs2976388 0.669 rs2976391 chr8:143762724 C/A cg05569086 chr8:143859399 LYNX1 0.34 5.84 0.31 1.28e-8 Urinary tract infection frequency; CRC trans rs1656966 1.000 rs1656966 chr3:186466252 C/T cg17697381 chr3:148709363 GYG1 0.4 6.16 0.32 2.11e-9 Myopia (pathological); CRC cis rs9372498 0.536 rs77435770 chr6:118819467 G/A cg15382696 chr6:118971807 C6orf204 0.61 8.01 0.4 2.07e-14 Diastolic blood pressure; CRC cis rs9640161 0.830 rs35635199 chr7:150063342 C/T cg13722127 chr7:150037890 RARRES2 0.4 5.74 0.3 2.21e-8 Blood protein levels;Circulating chemerin levels; CRC cis rs8060686 0.641 rs36086450 chr16:68046996 A/C cg08314208 chr16:67682810 RLTPR -0.65 -6.8 -0.35 4.91e-11 HDL cholesterol;Metabolic syndrome; CRC cis rs2404602 0.692 rs4360890 chr15:77173295 G/A cg22467129 chr15:76604101 ETFA -0.38 -6.07 -0.32 3.61e-9 Blood metabolite levels; CRC cis rs11212617 0.967 rs661467 chr11:108101492 A/G cg01991180 chr11:108092276 ATM;NPAT 0.4 5.75 0.3 2.08e-8 Response to metformin in type 2 diabetes (glycemic); CRC cis rs728616 0.867 rs56123058 chr10:81811072 G/A cg05935833 chr10:81318306 SFTPA2 -0.55 -6.45 -0.33 4.03e-10 Chronic obstructive pulmonary disease-related biomarkers; CRC trans rs2243480 1.000 rs4718315 chr7:65648541 T/C cg10756647 chr7:56101905 PSPH -0.76 -7.87 -0.4 5.31e-14 Diabetic kidney disease; CRC cis rs1577917 1.000 rs1995688 chr6:86632319 G/A cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.51 -6.74 -0.35 7.09e-11 Response to antipsychotic treatment; CRC cis rs1707322 1.000 rs1707303 chr1:46598273 A/C cg06784218 chr1:46089804 CCDC17 -0.54 -9.15 -0.45 6.35e-18 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC trans rs1864585 0.520 rs7009920 chr8:10585162 C/T cg26278703 chr11:58910052 FAM111A -0.5 -5.96 -0.31 6.4e-9 Neutrophil percentage of white cells;Lymphocyte percentage of white cells; CRC cis rs6831352 0.918 rs17218141 chr4:100055908 T/C cg13256891 chr4:100009986 ADH5 -0.66 -8.89 -0.44 4.04e-17 Alcohol dependence; CRC cis rs6502050 0.835 rs8065556 chr17:80091176 G/C cg25804541 chr17:80189381 SLC16A3 -0.3 -5.74 -0.3 2.19e-8 Life satisfaction; CRC cis rs9549367 0.789 rs9549711 chr13:113900557 C/T cg00898013 chr13:113819073 PROZ -0.46 -6.51 -0.34 2.77e-10 Platelet distribution width; CRC cis rs1448094 0.511 rs6539921 chr12:86164163 G/A cg25456477 chr12:86230367 RASSF9 0.38 6.48 0.34 3.29e-10 Major depressive disorder; CRC cis rs2066819 1.000 rs808919 chr12:56647911 C/G cg26714650 chr12:56694279 CS 1.08 12.26 0.56 1.03e-28 Psoriasis vulgaris; CRC cis rs2303745 0.622 rs1864113 chr19:17393504 G/C cg15110403 chr19:17392923 ANKLE1 -0.36 -6.0 -0.31 5.23e-9 Systemic lupus erythematosus; CRC cis rs1552244 0.938 rs9873794 chr3:10074153 T/G cg08888203 chr3:10149979 C3orf24 0.69 9.78 0.47 5.28e-20 Alzheimer's disease; CRC cis rs2404602 0.647 rs12898810 chr15:76904738 T/C cg23625390 chr15:77176239 SCAPER -0.87 -13.38 -0.59 6.83e-33 Blood metabolite levels; CRC cis rs4763879 0.739 rs7310460 chr12:9840773 A/T cg26689682 chr12:9723402 NA -0.34 -5.61 -0.3 4.21e-8 Type 1 diabetes; CRC cis rs7786808 0.649 rs1377374 chr7:158215647 G/T cg15440763 chr7:158190612 PTPRN2 -0.35 -5.76 -0.3 1.93e-8 Obesity-related traits; CRC trans rs4332037 0.510 rs11764040 chr7:1884830 G/C cg11693508 chr17:37793320 STARD3 0.54 7.67 0.39 1.93e-13 Bipolar disorder; CRC cis rs1691799 0.899 rs1168314 chr12:66746937 A/G cg16791601 chr12:66731901 HELB -0.73 -12.99 -0.58 1.9e-31 White blood cell count (basophil); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg25780156 chr19:1383710 NDUFS7 0.4 6.65 0.34 1.23e-10 Liver disease severity in Alagille syndrome; CRC cis rs35883536 0.588 rs12568329 chr1:101104588 A/G cg14515779 chr1:101123966 NA 0.35 6.15 0.32 2.3e-9 Monocyte count; CRC cis rs77633900 0.772 rs284907 chr15:76741569 A/G cg21673338 chr15:77095150 SCAPER -0.74 -6.46 -0.34 3.74e-10 Non-glioblastoma glioma;Glioma; CRC cis rs10504229 1.000 rs73607874 chr8:58173433 G/C cg01721255 chr8:58191610 C8orf71 0.49 6.17 0.32 2e-9 Developmental language disorder (linguistic errors); CRC cis rs1223397 0.938 rs20499 chr6:13295004 C/T cg06879394 chr6:13274151 PHACTR1 0.48 5.86 0.31 1.13e-8 Blood pressure; CRC cis rs6951245 0.832 rs79808627 chr7:1092519 C/G cg24642844 chr7:1081250 C7orf50 -0.61 -7.96 -0.4 2.85e-14 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs6076065 0.548 rs6048740 chr20:23325047 G/A cg11657817 chr20:23433608 CST11 0.58 9.99 0.48 1.05e-20 Facial morphology (factor 15, philtrum width); CRC trans rs6600671 1.000 rs11249350 chr1:121178446 C/T cg00646200 chr1:148855367 NA 0.34 6.23 0.32 1.41e-9 Hip geometry; CRC cis rs2404602 0.716 rs12594577 chr15:76828793 A/C cg00316803 chr15:76480434 C15orf27 -0.35 -5.79 -0.3 1.67e-8 Blood metabolite levels; CRC cis rs4819052 0.851 rs10470245 chr21:46658912 A/G cg11663144 chr21:46675770 NA -0.83 -14.12 -0.61 1.06e-35 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs2304069 0.954 rs10045945 chr5:149419297 C/T cg22760475 chr5:149380129 HMGXB3;TIGD6 0.87 10.35 0.5 6.45e-22 HIV-1 control; CRC cis rs3096299 0.586 rs4572400 chr16:89533516 T/A cg00750074 chr16:89608354 SPG7 -0.38 -5.63 -0.3 3.79e-8 Multiple myeloma (IgH translocation); CRC cis rs8141529 0.748 rs2064261 chr22:29287730 C/T cg02153584 chr22:29168773 CCDC117 0.46 6.58 0.34 1.91e-10 Lymphocyte counts; CRC cis rs8044995 0.563 rs57434514 chr16:68402649 G/A cg05110241 chr16:68378359 PRMT7 -0.73 -7.17 -0.37 4.91e-12 Schizophrenia; CRC cis rs3015497 0.789 rs1389652 chr14:51125240 T/C cg09863266 chr14:51125203 SAV1 -0.33 -6.18 -0.32 1.89e-9 Mean platelet volume; CRC cis rs7119 0.717 rs7176307 chr15:77816684 G/C cg10437265 chr15:77819839 NA 0.69 12.74 0.57 1.76e-30 Type 2 diabetes; CRC cis rs10504229 0.679 rs17193048 chr8:58055392 G/A cg08219700 chr8:58056026 NA 0.53 6.08 0.32 3.31e-9 Developmental language disorder (linguistic errors); CRC cis rs2153535 0.542 rs915353 chr6:8440370 A/G cg07606381 chr6:8435919 SLC35B3 0.68 10.86 0.51 1.08e-23 Motion sickness; CRC cis rs7945718 0.621 rs7939509 chr11:12688130 T/C cg25843174 chr11:12811716 TEAD1 0.39 7.17 0.37 5.06e-12 Educational attainment (years of education); CRC cis rs561341 1.000 rs548957 chr17:30302411 G/A cg00745463 chr17:30367425 LRRC37B -0.89 -9.87 -0.48 2.65e-20 Hip circumference adjusted for BMI; CRC trans rs8108034 1.000 rs39587 chr19:39806997 C/T cg22885777 chr19:15947555 NA -0.57 -6.3 -0.33 9.65e-10 Lung adenocarcinoma; CRC cis rs9894429 1.000 rs7213129 chr17:79581573 C/T cg13777783 chr17:79615861 NA -0.3 -5.72 -0.3 2.44e-8 Eye color traits; CRC cis rs1218582 0.710 rs7553195 chr1:154837796 T/C cg09359103 chr1:154839909 KCNN3 -0.69 -12.19 -0.56 1.78e-28 Prostate cancer; CRC trans rs1814175 0.546 rs1614397 chr11:49913384 G/C cg21153622 chr11:89784906 NA -0.38 -6.05 -0.32 3.99e-9 Height; CRC cis rs6921919 0.583 rs34513104 chr6:28343343 G/A cg21251018 chr6:28226885 NKAPL 0.39 6.02 0.31 4.74e-9 Autism spectrum disorder or schizophrenia; CRC cis rs3924048 0.574 rs3923904 chr1:12616535 T/C cg00291366 chr1:12616550 NA 0.59 10.93 0.52 6.23e-24 Optic cup area; CRC cis rs7680126 0.633 rs4698023 chr4:10304726 A/G cg00071950 chr4:10020882 SLC2A9 -0.43 -5.92 -0.31 7.93e-9 Urate levels in lean individuals;Urate levels in overweight individuals;Urate levels in obese individuals; CRC cis rs9322193 0.847 rs12234128 chr6:149948689 T/C cg05861140 chr6:150128134 PCMT1 -0.36 -5.9 -0.31 8.8e-9 Lung cancer; CRC cis rs73206853 0.841 rs73191808 chr12:110904685 T/C cg12870014 chr12:110450643 ANKRD13A 0.81 8.45 0.42 9.43e-16 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC cis rs7772486 0.754 rs9399561 chr6:145955687 C/G cg05347473 chr6:146136440 FBXO30 0.41 6.21 0.32 1.63e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs765787 0.530 rs13329228 chr15:45533017 C/T cg24006582 chr15:45444508 DUOX1 -0.54 -8.41 -0.42 1.23e-15 Uric acid levels; CRC trans rs561341 1.000 rs483301 chr17:30293398 G/T cg27661571 chr11:113659931 NA -0.96 -11.24 -0.53 5.07e-25 Hip circumference adjusted for BMI; CRC cis rs1552244 0.882 rs13074282 chr3:10024699 T/G cg08888203 chr3:10149979 C3orf24 0.62 8.23 0.41 4.29e-15 Alzheimer's disease; CRC cis rs12143943 0.966 rs4950953 chr1:204575481 A/G cg17419461 chr1:204415978 PIK3C2B 0.41 6.2 0.32 1.74e-9 Cognitive performance; CRC cis rs2976388 0.609 rs2585148 chr8:143796193 C/G cg12516270 chr8:143859308 LYNX1 0.42 7.54 0.38 4.51e-13 Urinary tract infection frequency; CRC cis rs3806843 0.966 rs2563261 chr5:140137713 G/T cg16607685 chr5:140181889 PCDHA2;PCDHA1;PCDHA3 0.28 6.41 0.33 5.1e-10 Depressive symptoms (multi-trait analysis); CRC cis rs11123170 0.543 rs2863242 chr2:113989236 C/T cg11763394 chr2:113992921 PAX8;LOC440839;LOC654433 0.5 5.76 0.3 1.93e-8 Renal function-related traits (BUN); CRC cis rs3820068 0.580 rs7556473 chr1:15996858 C/T cg24675056 chr1:15929824 NA -0.51 -7.12 -0.37 6.87e-12 Systolic blood pressure; CRC cis rs9322817 0.691 rs1933804 chr6:105341969 G/C cg02098413 chr6:105308735 HACE1 0.46 9.14 0.45 6.63e-18 Thyroid stimulating hormone; CRC trans rs7267979 0.933 rs1130694 chr20:25276297 G/A cg17903999 chr18:56338584 MALT1 -0.4 -6.57 -0.34 1.97e-10 Liver enzyme levels (alkaline phosphatase); CRC cis rs9326248 0.603 rs7396061 chr11:116750874 A/C cg11861562 chr11:117069780 TAGLN 0.29 6.38 0.33 5.97e-10 Blood protein levels; CRC cis rs4290604 0.665 rs4432400 chr2:238058938 A/G cg23555395 chr2:238036564 NA -0.63 -6.54 -0.34 2.36e-10 Asthma; CRC trans rs2303319 0.504 rs1006428 chr2:162592559 A/C cg25193742 chr10:104614220 C10orf32 -0.77 -6.51 -0.34 2.87e-10 Cognitive function; CRC cis rs8177179 0.967 rs4994582 chr3:133437566 G/C cg24879335 chr3:133465180 TF 0.44 8.62 0.43 2.9e-16 Iron status biomarkers (transferrin levels); CRC cis rs733592 0.507 rs7304428 chr12:48494275 T/G cg24011408 chr12:48396354 COL2A1 -0.45 -6.68 -0.35 1.03e-10 Plateletcrit; CRC cis rs9443645 0.901 rs9448580 chr6:79551812 C/G cg09184832 chr6:79620586 NA -0.5 -9.44 -0.46 7.08e-19 Intelligence (multi-trait analysis); CRC cis rs3736594 0.559 rs1919129 chr2:27818721 C/G cg27432699 chr2:27873401 GPN1 0.62 8.28 0.42 3.12e-15 Fasting blood glucose;Fasting blood glucose (BMI interaction); CRC cis rs473651 0.935 rs482775 chr2:239335403 G/C cg18131467 chr2:239335373 ASB1 1.04 24.3 0.8 2.09e-75 Multiple system atrophy; CRC cis rs9311474 0.597 rs13303 chr3:52558008 T/C cg10802521 chr3:52805072 NEK4 -0.42 -6.48 -0.34 3.35e-10 Electroencephalogram traits; CRC cis rs12134245 1.000 rs12134245 chr1:92021464 C/T cg02896835 chr1:92012615 NA -0.57 -9.24 -0.45 3.05e-18 Breast cancer; CRC cis rs10540 1.000 rs61876342 chr11:496193 T/G cg15790184 chr11:494944 RNH1 0.6 6.18 0.32 1.85e-9 Body mass index; CRC cis rs10751667 1.000 rs11246359 chr11:967943 T/C cg23136738 chr11:925521 AP2A2 -0.51 -8.28 -0.42 3.11e-15 Alzheimer's disease (late onset); CRC cis rs2243480 1.000 rs55895244 chr7:65387678 C/G cg12463550 chr7:65579703 CRCP 0.63 6.04 0.32 4.17e-9 Diabetic kidney disease; CRC cis rs2239547 0.618 rs13083728 chr3:52868445 G/A cg18404041 chr3:52824283 ITIH1 -0.41 -7.6 -0.39 3.03e-13 Schizophrenia; CRC cis rs9814567 0.964 rs6776203 chr3:134234345 C/T cg06109529 chr3:134205091 CEP63;ANAPC13 -0.81 -12.21 -0.56 1.6e-28 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs9467711 0.591 rs9467622 chr6:25854644 C/A cg16898833 chr6:26189333 HIST1H4D 0.79 6.5 0.34 2.95e-10 Autism spectrum disorder or schizophrenia; CRC trans rs951252 0.504 rs11734405 chr4:146081096 C/T cg06623486 chr1:162531613 UAP1 0.4 6.03 0.32 4.51e-9 Hip circumference; CRC cis rs1046896 0.553 rs3744160 chr17:80828303 G/A cg19500275 chr17:80737654 TBCD 0.5 6.77 0.35 6.06e-11 Glycated hemoglobin levels; CRC cis rs7916697 0.626 rs3858146 chr10:70013250 C/T cg06988349 chr10:69991859 ATOH7 0.39 7.49 0.38 6.27e-13 Optic disc area; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg24058025 chr1:44412156 IPO13 0.38 6.28 0.33 1.04e-9 Liver disease severity in Alagille syndrome; CRC cis rs11122272 0.735 rs2250749 chr1:231485763 C/G cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.54 -8.25 -0.41 3.74e-15 Hemoglobin concentration; CRC cis rs7044106 0.762 rs4837790 chr9:123446325 C/T cg14255062 chr9:123606675 PSMD5;LOC253039 0.44 6.77 0.35 5.86e-11 Hip circumference adjusted for BMI; CRC cis rs2204008 0.538 rs61931093 chr12:38242911 C/T cg26384229 chr12:38710491 ALG10B -0.52 -7.53 -0.38 4.97e-13 Bladder cancer; CRC cis rs12410462 0.681 rs6670816 chr1:227610592 G/T cg23173402 chr1:227635558 NA -0.76 -8.4 -0.42 1.36e-15 Major depressive disorder; CRC trans rs12310956 0.532 rs1525904 chr12:33962448 T/C cg26384229 chr12:38710491 ALG10B 0.52 6.57 0.34 1.99e-10 Morning vs. evening chronotype; CRC cis rs3858526 0.523 rs10769290 chr11:5886947 T/A cg26762873 chr11:5879799 OR52E8 -0.48 -7.51 -0.38 5.69e-13 DNA methylation (variation); CRC cis rs9399135 0.967 rs1854865 chr6:135360300 C/G cg24558204 chr6:135376177 HBS1L 0.49 7.8 0.4 8.22e-14 Red blood cell count; CRC cis rs2976388 0.609 rs2717601 chr8:143807924 T/C cg22687807 chr8:143858763 LYNX1 0.51 9.01 0.44 1.74e-17 Urinary tract infection frequency; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg00902873 chr3:127771089 SEC61A1 0.47 6.46 0.34 3.81e-10 Anxiety disorder; CRC cis rs17376456 0.877 rs10070390 chr5:93452345 G/A cg21475434 chr5:93447410 FAM172A 0.71 7.68 0.39 1.82e-13 Diabetic retinopathy; CRC cis rs9916302 0.904 rs11078910 chr17:37671269 G/T cg07936489 chr17:37558343 FBXL20 -0.84 -13.1 -0.59 7.41e-32 Glomerular filtration rate (creatinine); CRC cis rs8177253 0.965 rs8177260 chr3:133480458 T/A cg11941060 chr3:133502564 NA -0.61 -11.01 -0.52 3.36e-24 Iron status biomarkers; CRC cis rs9359856 0.564 rs1036853 chr6:90499502 G/A cg13799429 chr6:90582589 CASP8AP2 -0.73 -7.77 -0.39 1.04e-13 Bipolar disorder; CRC cis rs2213920 0.516 rs71505546 chr9:118158372 G/A cg13918206 chr9:118159781 DEC1 -0.83 -7.54 -0.38 4.63e-13 Docetaxel-induced peripheral neuropathy in metastatic castrate-resistant prostate cancer; CRC trans rs17685 0.753 rs4728586 chr7:75802869 T/C cg19862616 chr7:65841803 NCRNA00174 0.97 16.76 0.68 5.2e-46 Coffee consumption;Coffee consumption (cups per day); CRC trans rs7615952 0.673 rs35001498 chr3:125628644 A/G cg07211511 chr3:129823064 LOC729375 -1.1 -12.68 -0.57 2.87e-30 Blood pressure (smoking interaction); CRC cis rs11677416 0.677 rs2856840 chr2:113538604 T/A cg27083787 chr2:113543245 IL1A 0.44 6.25 0.33 1.25e-9 Response to antipsychotic treatment in schizophrenia (working memory); CRC cis rs6952808 1.000 rs6954521 chr7:1886865 C/A cg04267008 chr7:1944627 MAD1L1 -0.76 -10.84 -0.51 1.32e-23 Bipolar disorder and schizophrenia; CRC cis rs10504229 0.815 rs75577263 chr8:58188434 A/G cg01721255 chr8:58191610 C8orf71 0.49 6.17 0.32 2e-9 Developmental language disorder (linguistic errors); CRC cis rs4731207 0.662 rs4283967 chr7:124540535 T/C cg23710748 chr7:124431027 NA -0.37 -5.98 -0.31 5.75e-9 Cutaneous malignant melanoma; CRC cis rs3796352 0.881 rs35385050 chr3:52997945 C/A cg07884673 chr3:53033167 SFMBT1 0.76 6.13 0.32 2.45e-9 Immune reponse to smallpox (secreted IL-2); CRC cis rs6952808 0.543 rs4719436 chr7:2141239 G/A cg02951883 chr7:2050386 MAD1L1 -0.67 -10.45 -0.5 2.94e-22 Bipolar disorder and schizophrenia; CRC cis rs9875589 0.509 rs2731336 chr3:14091908 G/A cg14375111 chr3:14165186 TMEM43;CHCHD4 0.41 6.01 0.31 4.88e-9 Ovarian reserve; CRC cis rs67311347 1.000 rs112619360 chr3:40432645 T/G cg09455208 chr3:40491958 NA 0.44 8.82 0.44 6.88e-17 Renal cell carcinoma; CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg03865041 chr16:71842666 AP1G1 0.41 6.24 0.33 1.34e-9 Obesity-related traits; CRC cis rs1005277 0.579 rs176880 chr10:38401417 C/G cg00409905 chr10:38381863 ZNF37A 0.68 11.35 0.53 2.04e-25 Extrinsic epigenetic age acceleration; CRC cis rs12893668 0.572 rs34000399 chr14:104101417 T/C cg08213375 chr14:104286397 PPP1R13B 0.43 6.73 0.35 7.64e-11 Reticulocyte count; CRC cis rs1348850 0.632 rs13008833 chr2:178514439 G/C cg22681709 chr2:178499509 PDE11A -0.5 -9.36 -0.46 1.27e-18 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs751728 0.638 rs4713686 chr6:33787506 C/T cg25922239 chr6:33757077 LEMD2 0.44 6.09 0.32 3.08e-9 Crohn's disease; CRC cis rs2439831 0.867 rs3101443 chr15:43912372 C/G cg02155558 chr15:43621948 ADAL;LCMT2 0.64 7.16 0.37 5.47e-12 Lung cancer in ever smokers; CRC cis rs2243480 0.901 rs34807232 chr7:65965133 G/A cg12463550 chr7:65579703 CRCP 0.67 6.11 0.32 2.84e-9 Diabetic kidney disease; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg20364594 chr6:158981615 TMEM181 -0.4 -6.53 -0.34 2.5e-10 Myopia (pathological); CRC cis rs9649213 0.574 rs62478236 chr7:98030377 G/A cg21770322 chr7:97807741 LMTK2 0.52 8.34 0.42 1.99e-15 Prostate cancer (SNP x SNP interaction); CRC cis rs3026101 0.671 rs8077933 chr17:5299674 C/G cg25236894 chr17:5323110 RPAIN;NUP88 0.42 6.9 0.36 2.74e-11 Body mass index; CRC cis rs9905704 0.914 rs2643117 chr17:56829516 G/A cg12560992 chr17:57184187 TRIM37 0.52 7.17 0.37 4.85e-12 Testicular germ cell tumor; CRC cis rs10504229 0.953 rs72650891 chr8:58179697 T/G cg02290350 chr8:58132656 NA -0.42 -5.96 -0.31 6.62e-9 Developmental language disorder (linguistic errors); CRC cis rs28386778 0.897 rs2584624 chr17:61904546 A/G cg11494091 chr17:61959527 GH2 0.6 10.14 0.49 3.3e-21 Prudent dietary pattern; CRC cis rs9322193 0.962 rs3805749 chr6:150093682 C/T cg13206674 chr6:150067644 NUP43 0.67 9.32 0.46 1.7e-18 Lung cancer; CRC cis rs2857891 0.909 rs56372435 chr11:6938658 T/C cg17958423 chr11:6947583 ZNF215 0.58 6.08 0.32 3.27e-9 Response to cytadine analogues (cytosine arabinoside); CRC cis rs3858526 0.665 rs10839170 chr11:6003512 C/T cg26762873 chr11:5879799 OR52E8 -0.41 -5.9 -0.31 9.22e-9 DNA methylation (variation); CRC cis rs847577 0.630 rs2132276 chr7:97826340 G/A cg21770322 chr7:97807741 LMTK2 0.86 19.38 0.73 2.28e-56 Breast cancer; CRC cis rs295140 0.507 rs1369842 chr2:201108987 C/A cg23649088 chr2:200775458 C2orf69 -0.42 -6.1 -0.32 3.01e-9 QT interval; CRC cis rs7552404 0.696 rs1417405 chr1:76457797 T/C cg03433033 chr1:76189801 ACADM 0.69 8.26 0.41 3.57e-15 Blood metabolite levels;Acylcarnitine levels; CRC cis rs7666738 0.791 rs10022061 chr4:98926821 T/C cg17366294 chr4:99064904 C4orf37 0.43 7.32 0.37 1.95e-12 Colonoscopy-negative controls vs population controls; CRC trans rs5756813 0.661 rs11703407 chr22:38200124 C/T cg19894588 chr14:64061835 NA -0.63 -8.53 -0.43 5.3e-16 Optic cup area;Vertical cup-disc ratio; CRC cis rs4664293 0.802 rs13025347 chr2:160577567 G/A cg08347373 chr2:160653686 CD302 -0.47 -7.43 -0.38 9.32e-13 Monocyte percentage of white cells; CRC cis rs7428 0.527 rs4459734 chr2:85547429 G/T cg24342717 chr2:85555507 TGOLN2 -0.78 -12.69 -0.57 2.61e-30 Ear protrusion; CRC cis rs7927771 0.524 rs6485773 chr11:47763509 A/G cg20307385 chr11:47447363 PSMC3 0.46 6.55 0.34 2.26e-10 Subjective well-being; CRC trans rs12699921 0.598 rs2723504 chr7:17854833 T/A cg15753394 chr6:17282781 RBM24 -0.36 -6.03 -0.32 4.5e-9 Fibrinogen levels; CRC cis rs12451471 0.559 rs12452263 chr17:78079310 T/C cg24585782 chr17:78113791 EIF4A3 -0.52 -7.32 -0.37 1.97e-12 Plateletcrit;Mean corpuscular hemoglobin concentration; CRC cis rs9649213 0.593 rs56286037 chr7:98019522 C/T cg24562669 chr7:97807699 LMTK2 0.43 7.08 0.36 8.83e-12 Prostate cancer (SNP x SNP interaction); CRC cis rs7607369 0.536 rs4674345 chr2:219671598 A/G cg02176678 chr2:219576539 TTLL4 -0.4 -6.32 -0.33 8.5e-10 Red blood cell count;Amyotrophic lateral sclerosis; CRC cis rs3008870 1.000 rs2065000 chr1:67468124 G/C cg08660285 chr1:67390436 MIER1;WDR78 -1.03 -14.98 -0.64 5.06e-39 Lymphocyte percentage of white cells; CRC cis rs1559088 0.847 rs10423531 chr19:33600140 T/C cg27124370 chr19:33622961 WDR88 0.44 6.12 0.32 2.64e-9 Bone ultrasound measurement (broadband ultrasound attenuation); CRC cis rs4728142 1.000 rs4728142 chr7:128573967 C/T cg26616347 chr7:128577752 IRF5 -0.34 -5.75 -0.3 2.08e-8 Inflammatory bowel disease;Systemic lupus erythematosus;Ulcerative colitis; CRC cis rs7811142 0.830 rs10085549 chr7:99983135 C/T cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.76 10.68 0.51 4.55e-23 Platelet count; CRC cis rs932541 1.000 rs11699251 chr20:16456295 C/T cg17003395 chr20:16555519 KIF16B 0.41 5.65 0.3 3.39e-8 Intelligence; CRC cis rs1707322 1.000 rs4660895 chr1:46329739 C/T cg06784218 chr1:46089804 CCDC17 0.51 8.95 0.44 2.75e-17 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs3751196 0.614 rs78661975 chr12:104183952 G/A cg02344784 chr12:104178138 NT5DC3 0.7 7.16 0.37 5.23e-12 Sense of smell; CRC cis rs7264396 0.790 rs11697903 chr20:34272224 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.62 -10.41 -0.5 3.95e-22 Total cholesterol levels; CRC cis rs7149337 0.869 rs10137481 chr14:51694614 C/T cg23942311 chr14:51606299 NA 0.75 13.77 0.6 2.23e-34 Cancer; CRC cis rs6586163 0.527 rs3740286 chr10:90751340 A/G cg03111039 chr10:90751583 FAS;ACTA2 0.83 12.61 0.57 5.15e-30 Chronic lymphocytic leukemia; CRC cis rs6952407 1 rs6952407 chr7:66045512 A/G cg00343986 chr7:65444356 GUSB -0.5 -7.32 -0.37 1.96e-12 Cotinine glucuronidation; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg02634712 chr18:19750909 GATA6 0.41 6.1 0.32 3.01e-9 Response to antipsychotic treatment; CRC cis rs875971 0.755 rs10228885 chr7:65780529 C/G cg00343986 chr7:65444356 GUSB -0.45 -6.24 -0.33 1.32e-9 Aortic root size; CRC trans rs800082 0.516 rs1178894 chr3:144239854 A/G cg24215973 chr2:240111563 HDAC4 0.46 6.49 0.34 3.14e-10 Smoking behavior; CRC trans rs4263408 0.934 rs9683743 chr4:39703194 A/C cg26271690 chr1:202830559 LOC148709 -0.41 -5.98 -0.31 5.68e-9 Plasma amyloid beta peptide concentrations (ABx-40); CRC trans rs10435719 0.902 rs7459545 chr8:11804389 G/T cg08975724 chr8:8085496 FLJ10661 0.42 6.48 0.34 3.44e-10 C-reactive protein levels or triglyceride levels (pleiotropy); CRC trans rs6703335 0.870 rs10803142 chr1:243598234 A/G cg13183956 chr19:49652517 PPFIA3 0.41 6.09 0.32 3.12e-9 Schizophrenia;Schizophrenia, schizoaffective disorder or bipolar disorder; CRC trans rs8177876 0.731 rs77145371 chr16:81118660 A/G cg09779152 chr17:73205364 NUP85 0.61 5.99 0.31 5.57e-9 Plasma omega-3 polyunsaturated fatty acid level (eicosapentaenoic acid); CRC cis rs9733 0.596 rs72702585 chr1:150696427 G/A cg10589385 chr1:150898437 SETDB1 0.28 5.96 0.31 6.66e-9 Tonsillectomy; CRC cis rs2991971 0.934 rs7903 chr1:45976472 G/C cg03123370 chr1:45965343 CCDC163P;MMACHC -0.4 -6.17 -0.32 1.95e-9 High light scatter reticulocyte count; CRC cis rs9303401 0.527 rs7224468 chr17:56749943 C/T cg10487724 chr17:56770010 TEX14;RAD51C 0.75 8.9 0.44 3.95e-17 Cognitive test performance; CRC cis rs7726839 0.574 rs72705017 chr5:623733 G/A cg14541582 chr5:601475 NA -0.36 -7.3 -0.37 2.21e-12 Obesity-related traits; CRC cis rs7666738 0.830 rs7664169 chr4:99037859 C/T cg05340658 chr4:99064831 C4orf37 -0.59 -9.0 -0.44 1.85e-17 Colonoscopy-negative controls vs population controls; CRC trans rs2303319 0.504 rs1023835 chr2:162593973 A/G cg10272801 chr16:14013773 ERCC4 -0.68 -6.07 -0.32 3.49e-9 Cognitive function; CRC cis rs4665809 0.878 rs6720312 chr2:26364934 A/G cg22920501 chr2:26401640 FAM59B 0.58 7.33 0.37 1.75e-12 Gut microbiome composition (summer); CRC cis rs7762018 0.607 rs77392231 chr6:170057634 G/A cg19338460 chr6:170058176 WDR27 -1.2 -11.12 -0.52 1.38e-24 Thiazide-induced adverse metabolic effects in hypertensive patients; CRC cis rs1580019 0.961 rs2392056 chr7:32498953 T/C cg07520158 chr7:32535189 LSM5;AVL9 0.45 6.48 0.34 3.33e-10 Cognitive ability; CRC cis rs1003719 0.788 rs7276917 chr21:38451334 T/C cg10648535 chr21:38446584 PIGP;TTC3 0.53 7.5 0.38 6.05e-13 Eye color traits; CRC cis rs1552244 0.882 rs2030564 chr3:10039044 A/G cg13047869 chr3:10149882 C3orf24 0.52 6.99 0.36 1.52e-11 Alzheimer's disease; CRC cis rs17152411 0.895 rs11245422 chr10:126588143 T/C cg07906193 chr10:126599966 NA 0.57 6.47 0.34 3.61e-10 Height; CRC cis rs10193935 0.901 rs2286702 chr2:42555473 C/T cg27598129 chr2:42591480 NA -0.71 -8.17 -0.41 6.71e-15 Colonoscopy-negative controls vs population controls; CRC cis rs9467773 1.000 rs6456734 chr6:26566965 G/T cg09904177 chr6:26538194 HMGN4 0.86 14.82 0.63 2.06e-38 Intelligence (multi-trait analysis); CRC cis rs9388451 0.839 rs11154331 chr6:126111429 A/T cg10911889 chr6:126070802 HEY2 0.37 5.7 0.3 2.63e-8 Brugada syndrome; CRC cis rs4363385 0.818 rs10788853 chr1:153002231 C/T cg25856811 chr1:152973957 SPRR3 -0.26 -7.16 -0.37 5.44e-12 Inflammatory skin disease; CRC cis rs11098499 0.691 rs9307471 chr4:120261262 G/A cg24375607 chr4:120327624 NA 0.47 7.72 0.39 1.42e-13 Corneal astigmatism; CRC cis rs6951245 0.678 rs28600085 chr7:1169636 C/T cg24642844 chr7:1081250 C7orf50 -0.68 -8.61 -0.43 3.16e-16 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs9911578 0.835 rs9904993 chr17:56468569 G/T cg05425664 chr17:57184151 TRIM37 0.45 6.89 0.36 2.85e-11 Intelligence (multi-trait analysis); CRC trans rs10983614 1.000 rs7867776 chr9:120072627 A/G cg01719123 chr8:28244050 ZNF395 0.44 6.04 0.32 4.07e-9 Survival in pancreatic cancer; CRC cis rs990171 1.000 rs6705001 chr2:103076210 A/G cg03938978 chr2:103052716 IL18RAP 0.46 5.89 0.31 9.34e-9 Lymphocyte counts; CRC trans rs7819412 0.525 rs10086521 chr8:10783769 A/G cg06636001 chr8:8085503 FLJ10661 -0.61 -9.14 -0.45 6.65e-18 Triglycerides; CRC cis rs4742903 0.935 rs9942894 chr9:106914905 A/G cg21169611 chr9:106856078 SMC2 0.41 5.6 0.3 4.49e-8 High-grade serous ovarian cancer;Breast cancer; CRC cis rs7811142 1.000 rs11771419 chr7:99988403 A/G cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.96 13.0 0.58 1.85e-31 Platelet count; CRC cis rs9311474 0.508 rs3796353 chr3:52593230 C/T cg15147215 chr3:52552868 STAB1 -0.65 -11.31 -0.53 2.75e-25 Electroencephalogram traits; CRC cis rs6740322 0.696 rs11685054 chr2:43474295 C/T cg06169590 chr2:43455088 ZFP36L2;LOC100129726 -0.73 -9.19 -0.45 4.55e-18 Coronary artery disease; CRC cis rs9640161 0.673 rs11773351 chr7:150030963 T/C cg12556325 chr7:150026731 C7orf29;LRRC61 -0.5 -7.33 -0.37 1.74e-12 Blood protein levels;Circulating chemerin levels; CRC cis rs1577917 1.000 rs10455456 chr6:86670322 T/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.52 -6.8 -0.35 5.06e-11 Response to antipsychotic treatment; CRC trans rs79976124 0.879 rs12214948 chr6:66633603 G/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.77 9.51 0.46 4.33e-19 Type 2 diabetes; CRC trans rs7267979 1.000 rs6050564 chr20:25344231 G/A cg17903999 chr18:56338584 MALT1 0.43 7.12 0.37 6.83e-12 Liver enzyme levels (alkaline phosphatase); CRC cis rs919433 0.889 rs12693816 chr2:198208420 T/A cg03934865 chr2:198174659 NA -0.39 -6.17 -0.32 2.06e-9 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC cis rs798554 0.797 rs798487 chr7:2802943 G/A cg14895029 chr7:2775587 GNA12 -0.46 -6.64 -0.34 1.29e-10 Height; CRC cis rs9916302 0.752 rs676882 chr17:37433424 A/T cg15445000 chr17:37608096 MED1 -0.36 -6.42 -0.33 4.67e-10 Glomerular filtration rate (creatinine); CRC cis rs1401999 0.899 rs2313211 chr3:183738626 T/A cg20387954 chr3:183756860 HTR3D 0.45 7.68 0.39 1.79e-13 Anterior chamber depth; CRC cis rs9640161 0.702 rs11765692 chr7:150026567 C/T cg13722127 chr7:150037890 RARRES2 0.48 7.89 0.4 4.37e-14 Blood protein levels;Circulating chemerin levels; CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg02685901 chr6:43597772 MAD2L1BP;GTPBP2 -0.59 -7.26 -0.37 2.87e-12 Diisocyanate-induced asthma; CRC cis rs478304 0.651 rs11537193 chr11:65500003 A/C cg27068330 chr11:65405492 SIPA1 -0.63 -9.75 -0.47 6.92e-20 Acne (severe); CRC cis rs12291225 0.679 rs1043237 chr11:14289053 A/T cg19336497 chr11:14380999 RRAS2 -0.52 -8.74 -0.43 1.24e-16 Sense of smell; CRC cis rs1150668 0.768 rs1233713 chr6:28198281 A/G cg06470822 chr6:28175283 NA 0.61 9.36 0.46 1.26e-18 Pubertal anthropometrics; CRC cis rs4908768 0.501 rs2016084 chr1:8613418 C/A cg20416874 chr1:8611966 RERE -0.44 -6.31 -0.33 9.21e-10 Neuroticism (multi-trait analysis);Subjective well-being (multi-trait analysis); CRC cis rs3540 0.960 rs10083661 chr15:91022339 G/A cg22089800 chr15:90895588 ZNF774 0.5 7.97 0.4 2.64e-14 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; CRC cis rs6804368 0.649 rs2372214 chr3:30766438 T/C cg06106510 chr3:30762233 NA 0.4 7.11 0.37 7.16e-12 Blood metabolite levels; CRC cis rs7677751 0.806 rs4864858 chr4:55089953 T/A cg17187183 chr4:55093834 PDGFRA 0.52 7.53 0.38 4.78e-13 Corneal astigmatism; CRC cis rs977987 0.762 rs1364079 chr16:75393131 C/A cg03315344 chr16:75512273 CHST6 0.52 8.83 0.44 6.48e-17 Dupuytren's disease; CRC cis rs889398 0.741 rs10852461 chr16:69928846 T/C cg00738113 chr16:70207722 CLEC18C -0.35 -5.86 -0.31 1.12e-8 Body mass index; CRC cis rs7523050 0.643 rs35924015 chr1:109404626 T/C cg08274380 chr1:109419600 GPSM2 0.65 5.75 0.3 2.02e-8 Fat distribution (HIV); CRC cis rs7493 0.755 rs17883791 chr7:94999438 G/A cg04155289 chr7:94953770 PON1 -0.56 -7.02 -0.36 1.27e-11 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs651907 0.557 rs11925001 chr3:101373966 C/T cg11279151 chr3:101281821 RG9MTD1 -0.57 -7.74 -0.39 1.25e-13 Colorectal cancer; CRC cis rs7833986 0.501 rs2667981 chr8:56894303 T/A cg23139584 chr8:56987506 RPS20;SNORD54 0.79 11.35 0.53 2e-25 Height; CRC cis rs1799949 0.965 rs11658499 chr17:41334749 C/T cg05368731 chr17:41323189 NBR1 0.65 9.6 0.47 2.1e-19 Menopause (age at onset); CRC cis rs651907 0.557 rs13077925 chr3:101488181 T/A cg11279151 chr3:101281821 RG9MTD1 -0.57 -7.82 -0.4 7.35e-14 Colorectal cancer; CRC cis rs11166927 0.524 rs10092101 chr8:140830697 C/T cg16909799 chr8:140841666 TRAPPC9 -0.42 -6.16 -0.32 2.1e-9 Pediatric non-alcoholic fatty liver disease activity score; CRC cis rs9612 1.000 rs346524 chr19:44260572 T/C cg08581076 chr19:44259116 C19orf61 0.46 5.9 0.31 9.23e-9 Exhaled nitric oxide output; CRC cis rs7917772 0.503 rs7899576 chr10:104307504 G/A cg04362960 chr10:104952993 NT5C2 -0.4 -5.64 -0.3 3.61e-8 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC cis rs311392 0.525 rs311422 chr8:55105483 T/C cg06042504 chr8:55087323 NA -0.36 -5.71 -0.3 2.47e-8 Pelvic organ prolapse (moderate/severe); CRC cis rs644799 0.544 rs1254935 chr11:95631470 C/A cg25622487 chr11:95524042 FAM76B;CEP57 0.54 8.14 0.41 8.49e-15 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs7215564 0.908 rs35542453 chr17:78687242 T/G cg09596252 chr17:78655493 RPTOR 0.58 6.24 0.33 1.36e-9 Myopia (pathological); CRC trans rs7618501 0.966 rs7372966 chr3:49788969 T/C cg21659725 chr3:3221576 CRBN -0.91 -17.2 -0.69 9.93e-48 Intelligence (multi-trait analysis); CRC trans rs9929218 0.551 rs1886697 chr16:68716179 T/C cg04657470 chr2:198365150 HSPE1;HSPD1 1.22 29.74 0.85 3.03e-95 Colorectal cancer; CRC cis rs977987 0.806 rs35937717 chr16:75331567 C/A cg03315344 chr16:75512273 CHST6 0.52 8.85 0.44 5.35e-17 Dupuytren's disease; CRC cis rs7589728 1.000 rs2363731 chr2:88521793 C/T cg18490616 chr2:88469792 THNSL2 0.57 5.71 0.3 2.57e-8 Plasma clusterin levels; CRC trans rs60843830 1.000 rs3828165 chr2:220889 G/A cg11347411 chr7:150020925 ACTR3C;LRRC61 0.6 9.06 0.45 1.21e-17 Spherical equivalent (joint analysis main effects and education interaction); CRC cis rs2411233 0.935 rs2164011 chr15:39289029 G/A cg23129342 chr15:39283510 NA 0.3 5.63 0.3 3.78e-8 Platelet count; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg00605358 chr12:89747739 DUSP6 0.45 6.3 0.33 9.8e-10 Response to antipsychotic treatment; CRC cis rs11583043 0.957 rs6667932 chr1:101503755 G/A cg16556008 chr1:101360663 SLC30A7;EXTL2 0.45 5.82 0.31 1.42e-8 Ulcerative colitis;Inflammatory bowel disease; CRC cis rs10197940 0.662 rs4467261 chr2:152281391 G/C cg06191203 chr2:152266755 RIF1 -0.59 -8.71 -0.43 1.53e-16 Lung cancer; CRC cis rs2386661 0.516 rs61832676 chr10:5646337 G/A cg12223502 chr10:5658492 NA -0.37 -5.88 -0.31 1.03e-8 Breast cancer; CRC cis rs11190604 0.767 rs7392696 chr10:102182141 G/A cg16342193 chr10:102329863 NA -0.37 -6.0 -0.31 5.3300000000000004e-09 Palmitoleic acid (16:1n-7) levels; CRC cis rs4665809 1.000 rs3910272 chr2:26287842 T/A cg25036284 chr2:26402008 FAM59B -0.47 -5.86 -0.31 1.14e-8 Gut microbiome composition (summer); CRC cis rs7552404 1.000 rs12127402 chr1:76205643 C/A cg10523679 chr1:76189770 ACADM 0.83 11.37 0.53 1.75e-25 Blood metabolite levels;Acylcarnitine levels; CRC cis rs8077889 1.000 rs2342310 chr17:41866199 T/C cg16892393 chr17:41919603 NA 0.56 7.83 0.4 6.58e-14 Triglycerides; CRC cis rs644148 0.781 rs630469 chr19:44970167 T/C cg15540054 chr19:45004280 ZNF180 -0.68 -9.59 -0.47 2.37e-19 Personality dimensions; CRC cis rs1552244 1.000 rs2272123 chr3:10140115 G/A cg16606324 chr3:10149918 C3orf24 0.74 10.04 0.48 7.2e-21 Alzheimer's disease; CRC trans rs3736594 0.546 rs965813 chr2:27789861 T/A cg02184673 chr11:123066560 ASAM 0.3 6.04 0.32 4.13e-9 Fasting blood glucose;Fasting blood glucose (BMI interaction); CRC cis rs2635047 0.638 rs28718304 chr18:44632830 A/C cg19077165 chr18:44547161 KATNAL2 -0.42 -6.33 -0.33 8e-10 Educational attainment; CRC cis rs875971 0.545 rs1796217 chr7:66085918 A/G cg18876405 chr7:65276391 NA -0.46 -6.33 -0.33 7.93e-10 Aortic root size; CRC cis rs11785400 1.000 rs754957 chr8:143746416 A/G cg10596483 chr8:143751796 JRK 0.49 6.92 0.36 2.35e-11 Schizophrenia; CRC cis rs7923609 1.000 rs10761727 chr10:64995493 C/T cg08743896 chr10:65200160 JMJD1C -0.39 -5.62 -0.3 4.15e-8 Educational attainment;Liver enzyme levels (alkaline phosphatase); CRC trans rs3733585 0.699 rs1122142 chr4:9947548 G/C cg26043149 chr18:55253948 FECH -0.44 -6.65 -0.34 1.22e-10 Cleft plate (environmental tobacco smoke interaction); CRC cis rs7591163 0.959 rs11685995 chr2:228722008 T/C cg00063174 chr2:228736253 WDR69 -0.47 -6.33 -0.33 8.04e-10 Blood pressure; CRC cis rs7213347 0.707 rs216215 chr17:2140668 C/T cg15816464 chr17:2026533 SMG6 0.4 6.96 0.36 1.84e-11 Total body bone mineral density; CRC cis rs4363385 0.818 rs3795382 chr1:153004853 C/T cg25856811 chr1:152973957 SPRR3 -0.25 -6.93 -0.36 2.19e-11 Inflammatory skin disease; CRC cis rs13315871 1.000 rs71311868 chr3:58392874 A/G cg20936604 chr3:58311152 NA -0.73 -7.0 -0.36 1.46e-11 Cholesterol, total; CRC cis rs1129187 0.755 rs2274514 chr6:42934500 C/T cg09436375 chr6:42928200 GNMT -0.35 -6.5 -0.34 3.03e-10 Alzheimer's disease in APOE e4+ carriers; CRC trans rs6561151 0.681 rs2325088 chr13:44424063 T/C cg12856521 chr11:46389249 DGKZ 0.73 10.56 0.5 1.21e-22 Crohn's disease; CRC cis rs9837602 0.745 rs792834 chr3:99476121 C/G cg07805332 chr3:99536008 MIR548G;C3orf26 0.45 5.74 0.3 2.17e-8 Breast cancer; CRC cis rs6714710 0.603 rs116309486 chr2:98493359 A/G cg26665480 chr2:98280029 ACTR1B 0.54 7.31 0.37 2.07e-12 Posterior cortical atrophy and Alzheimer's disease; CRC cis rs11623869 0.614 rs11627052 chr14:103863476 A/G cg12935359 chr14:103987150 CKB 0.65 8.34 0.42 2.05e-15 Bone mineral density; CRC cis rs9611565 0.659 rs9607815 chr22:41950671 A/T cg03806693 chr22:41940476 POLR3H -1.15 -15.77 -0.66 3.94e-42 Vitiligo; CRC cis rs17345786 0.906 rs72946021 chr3:101250008 T/G cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.57 6.68 0.35 1.02e-10 Colonoscopy-negative controls vs population controls; CRC cis rs11098499 0.722 rs10025925 chr4:120271744 A/T cg09307838 chr4:120376055 NA 0.6 9.3 0.46 1.95e-18 Corneal astigmatism; CRC cis rs6960043 0.714 rs7784091 chr7:15047637 A/G cg19272540 chr7:15055459 NA -0.22 -5.86 -0.31 1.13e-8 Type 2 diabetes; CRC cis rs13191362 1.000 rs34918316 chr6:163005386 A/G cg23758597 chr6:163146217 PARK2 -0.55 -6.13 -0.32 2.54e-9 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs2739330 0.760 rs1007888 chr22:24241101 C/T cg15242686 chr22:24348715 GSTTP1 0.41 6.17 0.32 1.96e-9 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs3204270 0.639 rs6565620 chr17:79658100 C/T cg18367735 chr17:79674897 NA 0.5 6.01 0.31 4.93e-9 Dental caries; CRC cis rs644799 1.000 rs623191 chr11:95548359 A/G cg03916912 chr11:95522834 CEP57;FAM76B 0.95 18.15 0.71 1.71e-51 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs6570726 0.791 rs7765687 chr6:145915100 A/C cg13319975 chr6:146136371 FBXO30 -0.41 -6.05 -0.32 3.99e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs172166 0.694 rs1770131 chr6:28086413 C/T cg21251018 chr6:28226885 NKAPL 0.47 7.07 0.36 9.43e-12 Cardiac Troponin-T levels; CRC cis rs4727027 0.933 rs757738 chr7:148872351 T/G cg23583168 chr7:148888333 NA -0.93 -16.48 -0.67 6.56e-45 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC cis rs7618501 0.699 rs6446187 chr3:49907111 C/A cg24110177 chr3:50126178 RBM5 -0.46 -6.69 -0.35 9.46e-11 Intelligence (multi-trait analysis); CRC cis rs769267 0.930 rs10422819 chr19:19643028 C/A cg02546618 chr19:19431379 KIAA0892;SF4 0.44 6.11 0.32 2.88e-9 Tonsillectomy; CRC cis rs6674176 0.597 rs4660262 chr1:44382524 G/A cg12908607 chr1:44402522 ARTN -0.61 -11.24 -0.53 5.09e-25 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Cognitive ability; CRC cis rs1448094 0.791 rs11117122 chr12:86337749 A/C cg02569458 chr12:86230093 RASSF9 0.46 7.79 0.39 8.84e-14 Major depressive disorder; CRC cis rs887829 0.570 rs10168155 chr2:234596836 C/T cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.46 -7.13 -0.37 6.28e-12 Metabolic traits;Bilirubin levels;Cholelithiasis-related traits in sickle cell anemia;Metabolite levels;Total bilirubin levels in HIV-1 infection;Serum metabolite levels;Blood metabolite levels; CRC cis rs514406 0.505 rs269286 chr1:53169018 C/T cg24675658 chr1:53192096 ZYG11B 0.71 11.05 0.52 2.39e-24 Monocyte count; CRC cis rs7113874 0.569 rs10840077 chr11:8601210 A/T cg20771178 chr11:8615675 STK33 0.35 5.75 0.3 2.05e-8 Body mass index in physically active individuals;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs1799949 1.000 rs34059614 chr17:41303071 C/T cg05368731 chr17:41323189 NBR1 0.65 9.59 0.47 2.27e-19 Menopause (age at onset); CRC trans rs35110281 0.807 rs28840140 chr21:45039163 T/C cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.43 6.92 0.36 2.34e-11 Mean corpuscular volume; CRC cis rs4434138 0.594 rs7653028 chr3:52763000 A/T cg18404041 chr3:52824283 ITIH1 -0.39 -8.23 -0.41 4.37e-15 Intelligence (multi-trait analysis); CRC cis rs951366 0.668 rs823154 chr1:205762406 C/T cg17178900 chr1:205818956 PM20D1 0.77 11.82 0.55 4.29e-27 Menarche (age at onset); CRC cis rs9368481 0.524 rs12530345 chr6:26884243 T/C cg05192639 chr6:26864778 GUSBL1 0.34 6.03 0.32 4.5e-9 Autism spectrum disorder or schizophrenia; CRC trans rs804280 0.509 rs9886639 chr8:11784529 G/T cg06636001 chr8:8085503 FLJ10661 0.47 7.15 0.37 5.74e-12 Myopia (pathological); CRC cis rs7726839 0.555 rs4541696 chr5:581053 A/G cg16447950 chr5:562315 NA -0.52 -8.79 -0.44 8.46e-17 Obesity-related traits; CRC cis rs9611565 0.659 rs1810461 chr22:41927820 G/A cg06481639 chr22:41940642 POLR3H -0.53 -6.06 -0.32 3.64e-9 Vitiligo; CRC cis rs7811142 0.830 rs75636500 chr7:99947657 C/G cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.57 6.91 0.36 2.55e-11 Platelet count; CRC cis rs7552404 0.696 rs10782602 chr1:76464261 T/C cg22875332 chr1:76189707 ACADM 0.58 6.83 0.35 4.2e-11 Blood metabolite levels;Acylcarnitine levels; CRC cis rs1007738 0.542 rs7937410 chr11:47206082 C/G cg19486271 chr11:47235900 DDB2 0.41 5.61 0.3 4.27e-8 Bone mineral density (hip); CRC cis rs55883249 1.000 rs62119428 chr2:9743332 T/C cg23886495 chr2:9695866 ADAM17 0.5 5.78 0.3 1.78e-8 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; CRC cis rs12580194 0.593 rs11171430 chr12:55755254 A/G cg19537932 chr12:55886519 OR6C68 -0.67 -8.77 -0.44 9.66e-17 Cancer; CRC cis rs311392 0.967 rs4255114 chr8:55089450 G/A cg06042504 chr8:55087323 NA -0.44 -6.82 -0.35 4.35e-11 Pelvic organ prolapse (moderate/severe); CRC cis rs10504229 0.595 rs36081958 chr8:58117505 C/G cg22535103 chr8:58192502 C8orf71 -0.7 -9.19 -0.45 4.45e-18 Developmental language disorder (linguistic errors); CRC cis rs6460942 0.514 rs118124486 chr7:12470381 T/G cg20607287 chr7:12443886 VWDE -0.42 -6.2 -0.32 1.67e-9 Coronary artery disease; CRC cis rs9733 0.596 rs12089731 chr1:150647798 T/C cg15448220 chr1:150897856 SETDB1 0.45 6.43 0.33 4.42e-10 Tonsillectomy; CRC cis rs6951245 1.000 rs80212261 chr7:1114012 C/T cg24642844 chr7:1081250 C7orf50 -0.77 -9.14 -0.45 6.6e-18 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs1577917 0.839 rs1838956 chr6:86565263 A/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.44 -5.78 -0.3 1.75e-8 Response to antipsychotic treatment; CRC trans rs804280 0.509 rs13276433 chr8:11783036 A/G cg06636001 chr8:8085503 FLJ10661 0.49 7.68 0.39 1.89e-13 Myopia (pathological); CRC cis rs7119 0.717 rs8032405 chr15:77825344 A/G cg22256960 chr15:77711686 NA -0.45 -6.18 -0.32 1.84e-9 Type 2 diabetes; CRC cis rs9648716 1.000 rs10263448 chr7:140618013 C/T cg10747023 chr7:140774559 NA 0.46 5.99 0.31 5.42e-9 Type 2 diabetes; CRC cis rs7927592 0.913 rs12285993 chr11:68302538 A/G cg01657329 chr11:68192670 LRP5 -0.46 -6.58 -0.34 1.89e-10 Total body bone mineral density; CRC cis rs7635838 0.892 rs754015 chr3:11493945 T/C cg00170343 chr3:11313890 ATG7 0.43 6.62 0.34 1.49e-10 HDL cholesterol; CRC cis rs11608355 0.545 rs918107 chr12:109904198 C/T cg05360138 chr12:110035743 NA -0.77 -8.46 -0.42 8.61e-16 Neuroticism; CRC cis rs11098499 0.954 rs6838814 chr4:120392443 G/A cg24375607 chr4:120327624 NA 0.5 7.7 0.39 1.62e-13 Corneal astigmatism; CRC cis rs912057 0.833 rs1294426 chr6:6744477 T/C cg06612196 chr6:6737390 NA 0.51 8.19 0.41 5.86e-15 Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction); CRC cis rs9303280 0.901 rs2305479 chr17:38062217 C/T cg11212589 chr17:38028394 ZPBP2 0.45 8.39 0.42 1.42e-15 Self-reported allergy; CRC cis rs951366 0.789 rs823137 chr1:205738302 C/T cg23034840 chr1:205782522 SLC41A1 0.49 6.8 0.35 4.97e-11 Menarche (age at onset); CRC cis rs17711722 0.727 rs2658585 chr7:65461941 A/T cg18876405 chr7:65276391 NA 0.66 12.07 0.55 5.27e-28 Calcium levels; CRC cis rs6831352 0.918 rs28987088 chr4:100059139 T/C cg13256891 chr4:100009986 ADH5 -0.66 -8.89 -0.44 4.04e-17 Alcohol dependence; CRC cis rs10924970 0.649 rs12409696 chr1:235423607 T/C cg09010748 chr1:235293032 TOMM20 -0.41 -5.66 -0.3 3.37e-8 Asthma; CRC cis rs7739232 0.920 rs77771017 chr6:53529014 C/T cg15658676 chr6:53530538 KLHL31 -0.76 -5.9 -0.31 8.9e-9 Hip circumference adjusted for BMI; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg20165655 chr11:65339703 FAM89B 0.42 6.14 0.32 2.43e-9 Response to antipsychotic treatment; CRC trans rs4332037 0.624 rs11766944 chr7:1888051 G/A cg11693508 chr17:37793320 STARD3 0.64 8.24 0.41 4.22e-15 Bipolar disorder; CRC cis rs8062405 1.000 rs62037364 chr16:28868695 G/A cg16576597 chr16:28551801 NUPR1 0.48 6.83 0.35 4.14e-11 Cognitive ability (multi-trait analysis);Cognitive ability; CRC trans rs6951245 0.935 rs113365567 chr7:1108785 T/C cg13565492 chr6:43139072 SRF -0.72 -7.42 -0.38 9.94e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs11030122 0.702 rs10835403 chr11:3990941 A/C cg18678763 chr11:4115507 RRM1 0.51 7.35 0.38 1.58e-12 Mean platelet volume;Platelet distribution width; CRC cis rs12291225 0.679 rs34238445 chr11:14315915 C/T cg19336497 chr11:14380999 RRAS2 -0.52 -8.51 -0.42 6.16e-16 Sense of smell; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg05702952 chr2:173420889 PDK1 0.49 6.99 0.36 1.52e-11 Response to antipsychotic treatment; CRC cis rs9372498 0.536 rs77435770 chr6:118819467 G/A cg22561889 chr6:118971681 C6orf204 0.51 6.65 0.34 1.26e-10 Diastolic blood pressure; CRC cis rs6456156 0.742 rs3093026 chr6:167532690 A/G cg05540913 chr6:167530185 CCR6 0.35 6.32 0.33 8.33e-10 Primary biliary cholangitis; CRC cis rs870825 0.550 rs59051283 chr4:185646476 C/T cg04058563 chr4:185651563 MLF1IP 0.72 9.3 0.46 2.04e-18 Blood protein levels; CRC cis rs4862750 0.872 rs10027252 chr4:187873462 T/G cg03647317 chr4:187891568 NA -0.55 -9.99 -0.48 1.05e-20 Lobe attachment (rater-scored or self-reported); CRC trans rs12478296 0.901 rs67951957 chr2:243004901 A/G cg18288967 chr1:45987694 PRDX1 0.68 7.72 0.39 1.37e-13 Obesity-related traits; CRC cis rs17376456 0.757 rs6859757 chr5:93206042 C/T cg09848695 chr5:92956644 FAM172A;MIR2277 0.79 6.68 0.35 9.92e-11 Diabetic retinopathy; CRC cis rs7223966 0.883 rs2727317 chr17:61961302 C/T cg23903597 chr17:61704154 MAP3K3 -0.44 -6.05 -0.32 3.99e-9 Hip circumference adjusted for BMI;Body mass index; CRC cis rs12295403 0.691 rs9705036 chr11:18686916 A/G cg07538406 chr11:18686895 NA 0.51 6.92 0.36 2.31e-11 Ovarian reserve; CRC cis rs806795 0.605 rs6935954 chr6:26255451 A/G cg13736514 chr6:26305472 NA -0.53 -8.82 -0.44 6.88e-17 Mosquito bite size; CRC cis rs7044106 0.734 rs1981020 chr9:123388464 C/T cg09419670 chr9:123605666 PSMD5;LOC253039 0.73 12.03 0.55 7.15e-28 Hip circumference adjusted for BMI; CRC cis rs617791 0.508 rs747526 chr11:65776071 C/A cg09783858 chr11:65769428 EIF1AD;BANF1 0.5 7.47 0.38 7.16e-13 Breast cancer; CRC cis rs9660180 0.967 rs6603802 chr1:1812521 C/T cg05132306 chr1:1846340 CALML6 -0.48 -7.53 -0.38 4.89e-13 Body mass index; CRC cis rs8031584 0.706 rs798084 chr15:31126935 C/T cg08704250 chr15:31115839 NA -0.54 -9.59 -0.47 2.21e-19 Huntington's disease progression; CRC cis rs2070488 0.804 rs13063978 chr3:38476538 A/G cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.79 13.72 0.6 3.52e-34 Electrocardiographic conduction measures; CRC cis rs6502050 0.749 rs7406163 chr17:80086389 C/T cg13198984 chr17:80129470 CCDC57 -0.46 -7.97 -0.4 2.65e-14 Life satisfaction; CRC cis rs10924970 0.967 rs4659721 chr1:235426917 C/T cg26050004 chr1:235667680 B3GALNT2 0.4 5.98 0.31 5.81e-9 Asthma; CRC cis rs11758351 1.000 rs80095925 chr6:26184942 C/T cg00620190 chr6:26240307 HIST1H4F -0.49 -5.74 -0.3 2.19e-8 Gout;Renal underexcretion gout; CRC cis rs7927771 0.524 rs2170815 chr11:47875910 T/C cg20307385 chr11:47447363 PSMC3 0.45 6.62 0.34 1.48e-10 Subjective well-being; CRC cis rs2836974 0.965 rs9941894 chr21:40634058 C/T cg11644478 chr21:40555479 PSMG1 0.71 10.3 0.49 9.55e-22 Cognitive function; CRC cis rs10089 0.552 rs11955148 chr5:127557814 T/C cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.61 7.45 0.38 8.19e-13 Ileal carcinoids; CRC cis rs1976403 0.633 rs1780324 chr1:21821757 A/G cg20417195 chr1:21767127 NBPF3 0.4 5.8 0.3 1.54e-8 Liver enzyme levels (alkaline phosphatase); CRC cis rs16852403 0.517 rs10494512 chr1:178251680 A/G cg00404053 chr1:178313656 RASAL2 0.45 5.91 0.31 8.61e-9 Childhood ear infection; CRC cis rs13323323 0.691 rs9814256 chr3:44668037 A/T cg10263370 chr3:44754102 ZNF502 -0.42 -5.76 -0.3 1.91e-8 IgG glycosylation; CRC cis rs1552244 1.000 rs112509186 chr3:10156533 A/G cg13047869 chr3:10149882 C3orf24 0.58 7.85 0.4 5.85e-14 Alzheimer's disease; CRC cis rs7835763 0.518 rs2445904 chr8:119095507 C/T cg11592677 chr8:119110466 EXT1 0.41 7.08 0.36 8.88e-12 Autism spectrum disorder; CRC cis rs4975616 0.869 rs380286 chr5:1320247 G/A cg06550200 chr5:1325588 CLPTM1L -0.71 -11.13 -0.52 1.2e-24 Lung cancer; CRC cis rs3091242 0.904 rs6661533 chr1:25771715 A/G cg27572855 chr1:25598939 RHD 0.37 6.58 0.34 1.86e-10 Erythrocyte sedimentation rate; CRC cis rs1949733 0.523 rs16842557 chr4:8543985 C/T cg11789530 chr4:8429930 ACOX3 -0.56 -7.7 -0.39 1.66e-13 Response to antineoplastic agents; CRC trans rs7395662 0.746 rs8186207 chr11:48765365 T/C cg21153622 chr11:89784906 NA -0.48 -7.79 -0.39 8.59e-14 HDL cholesterol; CRC cis rs2839186 0.564 rs4819215 chr21:47623573 G/A cg05896524 chr21:47604654 C21orf56 0.38 5.68 0.3 3.03e-8 Testicular germ cell tumor; CRC cis rs6540559 1.000 rs2073485 chr1:209962794 G/A cg23283495 chr1:209979779 IRF6 0.47 7.15 0.37 5.7e-12 Cleft lip with or without cleft palate; CRC trans rs6819266 0.636 rs13148734 chr4:63330858 A/G cg19091447 chr20:37555378 FAM83D 0.39 5.99 0.31 5.47e-9 Age-related macular degeneration; CRC cis rs3892630 0.824 rs34425841 chr19:33231619 C/T cg22980127 chr19:33182716 NUDT19 0.89 9.23 0.45 3.35e-18 Red blood cell traits; CRC cis rs7647973 0.626 rs11720705 chr3:49753788 A/G cg03060546 chr3:49711283 APEH 0.66 8.25 0.41 3.83e-15 Menarche (age at onset); CRC cis rs10504229 0.775 rs72650876 chr8:58161638 G/A cg08219700 chr8:58056026 NA 0.46 5.61 0.3 4.24e-8 Developmental language disorder (linguistic errors); CRC cis rs56399783 0.708 rs56208415 chr7:2813806 G/A cg19731401 chr7:2775893 GNA12 0.58 6.61 0.34 1.55e-10 Childhood ear infection; CRC cis rs9463078 0.547 rs720576 chr6:44729974 A/T cg25276700 chr6:44698697 NA 0.31 7.79 0.39 8.85e-14 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; CRC cis rs769267 0.930 rs751856 chr19:19602945 A/G cg03709012 chr19:19516395 GATAD2A 0.72 11.24 0.53 4.91e-25 Tonsillectomy; CRC cis rs72945132 0.882 rs11235755 chr11:70136323 A/G cg00319359 chr11:70116639 PPFIA1 0.67 7.4 0.38 1.16e-12 Coronary artery disease; CRC cis rs7772486 0.754 rs9373476 chr6:146139741 C/G cg13319975 chr6:146136371 FBXO30 -0.44 -6.58 -0.34 1.91e-10 Lobe attachment (rater-scored or self-reported); CRC cis rs6988985 0.560 rs3753122 chr8:143926927 G/T cg10324643 chr8:143916377 GML 0.35 5.93 0.31 7.71e-9 Plasma androstenedione levels in resected early stage-receptor positive breast cancer; CRC cis rs9612 1.000 rs346534 chr19:44250831 A/G cg08581076 chr19:44259116 C19orf61 0.47 6.09 0.32 3.07e-9 Exhaled nitric oxide output; CRC cis rs10504229 0.683 rs7827881 chr8:58132137 C/T cg05313129 chr8:58192883 C8orf71 -0.43 -6.01 -0.31 4.92e-9 Developmental language disorder (linguistic errors); CRC cis rs7618915 0.524 rs12488461 chr3:52698417 T/C cg18404041 chr3:52824283 ITIH1 -0.44 -9.03 -0.45 1.49e-17 Bipolar disorder; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg06473773 chr20:37063729 LOC388796;SNORA71D 0.45 6.38 0.33 5.97e-10 Response to antipsychotic treatment; CRC cis rs12586317 0.576 rs2415264 chr14:35630377 C/G cg07166546 chr14:35805898 NA -0.31 -6.11 -0.32 2.76e-9 Psoriasis; CRC cis rs4713118 0.614 rs9380007 chr6:27660508 T/C cg25164649 chr6:28176230 NA 0.49 7.15 0.37 5.67e-12 Parkinson's disease; CRC cis rs7727544 0.661 rs273900 chr5:131694606 G/A cg12564285 chr5:131593104 PDLIM4 0.33 6.05 0.32 3.96e-9 Blood metabolite levels; CRC cis rs9914988 0.943 rs11656256 chr17:27153553 G/A cg07195577 chr17:27052828 TLCD1 0.41 5.92 0.31 7.89e-9 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs9910055 0.762 rs7213436 chr17:42252163 A/G cg10896456 chr17:42255109 ASB16;C17orf65 -0.45 -7.24 -0.37 3.14e-12 Total body bone mineral density; CRC cis rs875971 0.830 rs1167406 chr7:65556936 G/C cg11764359 chr7:65958608 NA -0.58 -8.83 -0.44 6.38e-17 Aortic root size; CRC cis rs8114671 0.528 rs6119542 chr20:33484545 G/T cg07148914 chr20:33460835 GGT7 0.4 6.53 0.34 2.46e-10 Height; CRC cis rs992157 0.585 rs62182795 chr2:219100202 C/T cg00012203 chr2:219082015 ARPC2 -0.54 -8.52 -0.43 5.77e-16 Colorectal cancer; CRC cis rs11148252 0.514 rs3818422 chr13:52719214 C/T cg12458913 chr13:53173898 NA -0.39 -5.69 -0.3 2.85e-8 Lewy body disease; CRC trans rs10242455 0.702 rs76840929 chr7:98945858 T/C cg09045935 chr12:6379348 NA 0.94 7.14 0.37 5.9e-12 Blood metabolite levels; CRC cis rs2404602 0.716 rs66754747 chr15:76828568 G/A cg03037974 chr15:76606532 NA 0.67 11.43 0.53 1.06e-25 Blood metabolite levels; CRC cis rs7945705 0.846 rs905290 chr11:8753729 A/G cg14711859 chr11:8959438 ASCL3 -0.38 -5.91 -0.31 8.33e-9 Hemoglobin concentration; CRC cis rs11247915 1.000 rs11247915 chr1:26650550 G/T cg20415053 chr1:26527928 CATSPER4 -0.33 -5.64 -0.3 3.71e-8 Obesity-related traits; CRC cis rs1215050 0.791 rs10856931 chr4:98819306 C/T cg05340658 chr4:99064831 C4orf37 0.48 7.14 0.37 5.89e-12 Waist-to-hip ratio adjusted for body mass index; CRC cis rs4820294 0.961 rs62236664 chr22:38059427 T/C cg21798802 chr22:38057573 PDXP 0.47 7.34 0.37 1.73e-12 Fat distribution (HIV); CRC cis rs9926296 0.508 rs1558184 chr16:89842374 T/G cg21285383 chr16:89894308 SPIRE2 0.37 6.25 0.33 1.3e-9 Vitiligo; CRC cis rs1008375 1.000 rs1860597 chr4:17657650 C/T cg04450456 chr4:17643702 FAM184B 0.41 6.6 0.34 1.61e-10 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs6860806 0.507 rs2631372 chr5:131703578 C/G cg20512303 chr5:131592959 PDLIM4 0.36 6.05 0.32 3.9e-9 Breast cancer; CRC cis rs7909074 0.966 rs4948645 chr10:45391481 A/G cg05187965 chr10:45406764 TMEM72 -0.35 -7.91 -0.4 3.87e-14 Mean corpuscular volume; CRC cis rs7394190 0.935 rs6480708 chr10:75420114 C/A cg07699608 chr10:75541558 CHCHD1 0.55 6.22 0.32 1.48e-9 Incident atrial fibrillation; CRC cis rs1448094 0.512 rs10779216 chr12:86240315 A/G cg02569458 chr12:86230093 RASSF9 -0.42 -7.26 -0.37 2.81e-12 Major depressive disorder; CRC cis rs60871478 1.000 rs62432242 chr7:797715 G/A cg13844804 chr7:814759 HEATR2 0.66 8.51 0.42 6.28e-16 Cerebrospinal P-tau181p levels; CRC cis rs7107174 1.000 rs11237471 chr11:78082604 C/T cg02023728 chr11:77925099 USP35 0.47 7.8 0.4 8.13e-14 Testicular germ cell tumor; CRC cis rs992157 0.835 rs7559416 chr2:219150211 A/G cg13835894 chr2:219148914 PNKD;TMBIM1 -0.34 -6.52 -0.34 2.63e-10 Colorectal cancer; CRC cis rs2573652 1.000 rs2573625 chr15:100513158 A/G cg00587665 chr15:100533223 ADAMTS17 0.34 5.74 0.3 2.14e-8 Height; CRC cis rs12540874 0.895 rs4245556 chr7:50661661 C/T cg18232548 chr7:50535776 DDC -0.45 -6.3 -0.33 9.59e-10 Systemic sclerosis; CRC cis rs4713118 0.866 rs2179094 chr6:27741825 T/C cg12172441 chr6:28176163 NA 0.55 7.17 0.37 4.99e-12 Parkinson's disease; CRC cis rs6860806 0.507 rs183898 chr5:131716902 C/G cg09877947 chr5:131593287 PDLIM4 -0.44 -7.2 -0.37 4.05e-12 Breast cancer; CRC cis rs4700695 0.640 rs27083 chr5:65435865 C/T cg21114390 chr5:65439923 SFRS12 -0.63 -8.31 -0.42 2.53e-15 Facial morphology (factor 19); CRC trans rs7824557 0.707 rs3808519 chr8:11142970 C/G cg06636001 chr8:8085503 FLJ10661 0.46 6.54 0.34 2.36e-10 Retinal vascular caliber; CRC cis rs6951245 0.554 rs35126802 chr7:1134842 C/T cg26224354 chr7:1096374 C7orf50;GPR146 -0.6 -8.1 -0.41 1.09e-14 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs4713118 0.824 rs9468225 chr6:27745719 T/G cg12172441 chr6:28176163 NA 0.57 7.32 0.37 1.93e-12 Parkinson's disease; CRC cis rs7705042 0.796 rs1835965 chr5:141501771 G/A cg08523384 chr5:141488047 NDFIP1 -0.34 -6.08 -0.32 3.29e-9 Asthma; CRC cis rs7809950 0.817 rs2237671 chr7:107131528 A/T cg23024343 chr7:107201750 COG5 -0.73 -9.99 -0.48 1.06e-20 Coronary artery disease; CRC cis rs4478858 0.595 rs4949387 chr1:31803440 T/A cg00250761 chr1:31883323 NA -0.44 -8.5 -0.42 6.85e-16 Alcohol dependence; CRC cis rs2836974 0.590 rs9974757 chr21:40617244 T/C cg22974920 chr21:40686053 BRWD1 -0.43 -5.97 -0.31 6.04e-9 Cognitive function; CRC cis rs4865169 0.783 rs7668814 chr4:57825190 A/G cg25525207 chr4:57843836 C4orf14;POLR2B -0.49 -7.15 -0.37 5.49e-12 Breast cancer; CRC cis rs7107174 1.000 rs4134379 chr11:77992588 A/G cg02023728 chr11:77925099 USP35 0.46 8.04 0.41 1.65e-14 Testicular germ cell tumor; CRC cis rs1799949 0.965 rs11657883 chr17:41330024 T/C cg19454999 chr17:41278357 BRCA1;NBR2 0.54 8.25 0.41 3.98e-15 Menopause (age at onset); CRC cis rs9911578 1.000 rs9901181 chr17:56964271 C/T cg05425664 chr17:57184151 TRIM37 -0.5 -7.79 -0.39 8.96e-14 Intelligence (multi-trait analysis); CRC trans rs12887734 0.524 rs17791722 chr14:104286210 C/T cg06206626 chr22:26825900 ASPHD2 0.41 6.15 0.32 2.22e-9 Schizophrenia;Autism spectrum disorder or schizophrenia; CRC cis rs2075371 0.829 rs9641970 chr7:134004887 C/A cg20476274 chr7:133979776 SLC35B4 0.69 11.35 0.53 2.12e-25 Mean platelet volume; CRC cis rs728616 0.867 rs12412226 chr10:81735288 C/T cg11900509 chr10:81946545 ANXA11 -0.68 -6.82 -0.35 4.39e-11 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs11679072 1.000 rs6724234 chr2:240448917 G/A cg03276489 chr2:240449683 NA -0.96 -9.27 -0.45 2.58e-18 Blood pressure (smoking interaction); CRC cis rs1577917 1.000 rs2324843 chr6:86617501 A/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.56 -6.95 -0.36 2.01e-11 Response to antipsychotic treatment; CRC trans rs10982213 0.830 rs2274163 chr9:117188714 C/T cg05955566 chr12:99038273 IKBIP;APAF1 0.41 6.06 0.32 3.67e-9 Interleukin-6 levels; CRC cis rs5758511 0.680 rs1107553 chr22:42667473 A/G cg00645731 chr22:42541494 CYP2D7P1 0.63 9.69 0.47 1.04e-19 Birth weight; CRC cis rs9469913 0.668 rs112563428 chr6:34800435 C/T cg17674042 chr6:34482479 PACSIN1 -0.79 -7.81 -0.4 7.87e-14 Body mass index (joint analysis main effects and physical activity interaction);Body mass index;Body mass index in physically active individuals; CRC cis rs7833790 0.929 rs10958048 chr8:82792914 C/T cg17211192 chr8:82754475 SNX16 0.51 6.19 0.32 1.8e-9 Diastolic blood pressure; CRC cis rs7586879 0.575 rs6721750 chr2:25128719 A/G cg04586622 chr2:25135609 ADCY3 -0.54 -10.01 -0.48 8.89e-21 Body mass index; CRC trans rs116095464 0.558 rs59113266 chr5:279965 T/C cg00938859 chr5:1591904 SDHAP3 0.71 7.58 0.39 3.45e-13 Breast cancer; CRC cis rs28386778 0.799 rs12450683 chr17:61984299 C/G cg06873352 chr17:61820015 STRADA 0.66 12.71 0.57 2.29e-30 Prudent dietary pattern; CRC cis rs4728302 0.869 rs10253633 chr7:133590869 A/G cg10665199 chr7:133106180 EXOC4 0.38 5.85 0.31 1.22e-8 Intelligence;Intelligence (multi-trait analysis); CRC cis rs3733585 0.726 rs4306953 chr4:9955776 G/A cg00071950 chr4:10020882 SLC2A9 -0.55 -9.78 -0.47 5.18e-20 Cleft plate (environmental tobacco smoke interaction); CRC cis rs1975974 0.935 rs41361749 chr17:21732693 A/G cg18423549 chr17:21743878 NA 0.59 8.37 0.42 1.66e-15 Psoriasis; CRC cis rs561341 1.000 rs72823785 chr17:30273784 C/T cg23018236 chr17:30244563 NA -0.65 -7.78 -0.39 9.41e-14 Hip circumference adjusted for BMI; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg11105980 chr13:37393381 RFXAP 0.39 6.1 0.32 2.9e-9 Liver disease severity in Alagille syndrome; CRC cis rs10540 1.000 rs61876334 chr11:487201 T/C cg03934478 chr11:495069 RNH1 0.67 7.22 0.37 3.66e-12 Body mass index; CRC cis rs1008375 1.000 rs7697889 chr4:17617961 G/T cg02297831 chr4:17616191 MED28 0.43 5.82 0.31 1.36e-8 Parasitemia in Tripanosoma cruzi seropositivity; CRC trans rs12599106 0.629 rs1391904 chr16:34548934 C/T cg05064044 chr6:292385 DUSP22 -0.58 -8.0 -0.4 2.16e-14 Menopause (age at onset); CRC cis rs7107174 1.000 rs10899486 chr11:78072398 A/G cg02023728 chr11:77925099 USP35 0.49 7.47 0.38 7.48e-13 Testicular germ cell tumor; CRC cis rs1048238 0.506 rs7547314 chr1:16186722 G/A cg21385522 chr1:16154831 NA 0.6 8.89 0.44 4.26e-17 Systolic blood pressure; CRC cis rs7945705 0.747 rs2568020 chr11:8994715 C/T cg14711859 chr11:8959438 ASCL3 0.38 6.43 0.33 4.45e-10 Hemoglobin concentration; CRC cis rs870825 0.929 rs72689265 chr4:185590982 A/G cg04058563 chr4:185651563 MLF1IP 0.56 5.89 0.31 9.54e-9 Blood protein levels; CRC cis rs2242116 1.000 rs1138518 chr3:46944274 T/C cg02527881 chr3:46936655 PTH1R -0.52 -9.58 -0.47 2.37e-19 Birth weight; CRC cis rs853679 0.517 rs67878650 chr6:28142587 G/C cg18032046 chr6:28092343 ZSCAN16 -0.52 -5.93 -0.31 7.58e-9 Depression; CRC cis rs12586317 0.586 rs74243591 chr14:35520917 C/T cg05294307 chr14:35346193 BAZ1A -0.7 -7.33 -0.37 1.76e-12 Psoriasis; CRC cis rs7776786 0.934 rs17349342 chr7:18815473 A/C cg13420273 chr7:18810212 HDAC9 0.33 6.37 0.33 6.29e-10 Lobe attachment (rater-scored or self-reported); CRC cis rs8078723 1.000 rs4794823 chr17:38166265 A/T cg17467752 chr17:38218738 THRA 0.73 12.0 0.55 9.38e-28 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); CRC cis rs2617583 0.509 rs748209 chr5:1457554 A/C cg07148919 chr5:1466943 LPCAT1 -0.45 -5.86 -0.31 1.1e-8 Breast cancer; CRC cis rs11098499 0.644 rs3806808 chr4:120551085 A/C cg09307838 chr4:120376055 NA 0.62 9.4 0.46 9.25e-19 Corneal astigmatism; CRC cis rs2153535 0.504 rs9328472 chr6:8470848 G/A cg21535247 chr6:8435926 SLC35B3 0.5 7.53 0.38 4.89e-13 Motion sickness; CRC cis rs9549367 0.774 rs9549364 chr13:113903745 T/C cg18105134 chr13:113819100 PROZ -0.74 -10.65 -0.51 6.16e-23 Platelet distribution width; CRC cis rs765787 0.530 rs12906537 chr15:45520061 T/C cg24006582 chr15:45444508 DUOX1 0.56 8.08 0.41 1.22e-14 Uric acid levels; CRC cis rs6500602 0.727 rs6500607 chr16:4503631 C/T cg08645402 chr16:4508243 NA 0.6 10.6 0.5 8.69e-23 Schizophrenia; CRC trans rs2303319 0.504 rs56407015 chr2:162455625 G/A cg10272801 chr16:14013773 ERCC4 -0.68 -6.01 -0.31 4.9e-9 Cognitive function; CRC cis rs1728785 0.818 rs12926059 chr16:68569459 T/C cg02972257 chr16:68554789 NA -0.58 -7.15 -0.37 5.78e-12 Ulcerative colitis; CRC cis rs10782582 0.609 rs1796810 chr1:76403305 C/T cg10523679 chr1:76189770 ACADM -0.4 -5.75 -0.3 2.07e-8 Daytime sleep phenotypes; CRC cis rs1707322 1.000 rs10890372 chr1:46391020 T/G cg06784218 chr1:46089804 CCDC17 0.51 8.98 0.44 2.07e-17 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC trans rs61931739 0.517 rs7958755 chr12:34294699 T/C cg26384229 chr12:38710491 ALG10B 0.53 6.75 0.35 6.88e-11 Morning vs. evening chronotype; CRC cis rs4363385 0.818 rs407103 chr1:153007106 C/T cg25856811 chr1:152973957 SPRR3 0.25 6.89 0.36 2.87e-11 Inflammatory skin disease; CRC trans rs10242455 1.000 rs10229552 chr7:99234899 T/A cg09045935 chr12:6379348 NA 0.6 6.6 0.34 1.65e-10 Blood metabolite levels; CRC cis rs17331151 0.505 rs34182518 chr3:52743854 G/A cg07884673 chr3:53033167 SFMBT1 0.78 5.68 0.3 2.9e-8 Immune reponse to smallpox (secreted IL-2); CRC cis rs10979 0.679 rs9321918 chr6:143883460 T/C cg25407410 chr6:143891975 LOC285740 -0.68 -9.49 -0.46 4.84e-19 Hypospadias; CRC cis rs3785574 0.927 rs2854183 chr17:61968002 C/T cg22520471 chr17:61851767 DDX42;CCDC47 0.47 6.36 0.33 6.64e-10 Height; CRC cis rs2898681 0.770 rs10032190 chr4:53734940 C/A cg00338735 chr4:53728038 RASL11B 0.38 5.95 0.31 6.69e-9 Optic nerve measurement (cup area); CRC cis rs4819052 0.851 rs2838829 chr21:46664040 A/C cg19498844 chr21:46707878 POFUT2;LOC642852 0.77 11.29 0.53 3.29e-25 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs736408 0.522 rs998909 chr3:52805093 A/G cg11645453 chr3:52864694 ITIH4 0.35 6.27 0.33 1.16e-9 Bipolar disorder; CRC cis rs9462027 0.628 rs9296127 chr6:34719628 C/G cg07306190 chr6:34760872 UHRF1BP1 -0.35 -6.19 -0.32 1.75e-9 Systemic lupus erythematosus; CRC cis rs4665809 0.878 rs6748745 chr2:26364190 C/T cg04944784 chr2:26401820 FAM59B -0.64 -7.55 -0.38 4.45e-13 Gut microbiome composition (summer); CRC cis rs7089973 0.872 rs60820172 chr10:116625891 C/T cg03647239 chr10:116582469 FAM160B1 0.41 5.79 0.3 1.67e-8 Bipolar disorder or attention deficit hyperactivity disorder; CRC cis rs2832191 0.646 rs2832214 chr21:30517127 C/T cg08807101 chr21:30365312 RNF160 -0.51 -7.04 -0.36 1.16e-11 Dental caries; CRC cis rs4862750 0.872 rs6825289 chr4:187879109 T/G cg22105103 chr4:187893119 NA 0.64 11.86 0.55 2.89e-27 Lobe attachment (rater-scored or self-reported); CRC cis rs6479527 0.875 rs10429556 chr9:96805635 C/T cg14459158 chr9:96720562 NA 0.38 6.71 0.35 8.37e-11 Esophageal adenocarcinoma; CRC cis rs2727020 0.523 rs7948958 chr11:49506749 G/A cg27395922 chr11:50257633 LOC441601 0.36 5.73 0.3 2.25e-8 Coronary artery disease; CRC cis rs1336900 0.637 rs35967040 chr1:150555588 A/C cg17724175 chr1:150552817 MCL1 -0.68 -11.35 -0.53 2.06e-25 Blood protein levels; CRC cis rs1401999 0.628 rs6798870 chr3:183740350 G/A cg01324343 chr3:183735012 ABCC5 0.74 13.51 0.6 2.17e-33 Anterior chamber depth; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg10448528 chr11:123612020 ZNF202 0.45 6.4 0.33 5.21e-10 Response to antipsychotic treatment; CRC cis rs2050392 0.799 rs303429 chr10:30708441 C/T cg18806716 chr10:30721971 MAP3K8 -0.49 -7.37 -0.38 1.4e-12 Inflammatory bowel disease; CRC cis rs1348850 0.914 rs10170546 chr2:178248790 C/T cg02961200 chr2:178257176 LOC100130691;AGPS 0.61 9.16 0.45 5.79e-18 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs12701220 0.901 rs12701708 chr7:1090333 C/T cg26240231 chr7:1148101 C7orf50 -0.41 -5.79 -0.3 1.68e-8 Bronchopulmonary dysplasia; CRC cis rs35520189 0.556 rs13026837 chr2:113705673 G/A cg12858261 chr2:113808755 IL1F8 0.45 5.97 0.31 6.31e-9 Obstructive sleep apnea trait (apnea hypopnea index); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg05952120 chr17:61554416 ACE 0.48 7.83 0.4 6.93e-14 Liver disease severity in Alagille syndrome; CRC cis rs7647973 1.000 rs62259944 chr3:49430883 G/A cg07690219 chr3:49449608 TCTA;RHOA 0.52 5.71 0.3 2.54e-8 Menarche (age at onset); CRC cis rs9322193 0.923 rs56397000 chr6:150060483 C/T cg13206674 chr6:150067644 NUP43 0.66 10.02 0.48 8.65e-21 Lung cancer; CRC cis rs6499244 0.508 rs11642008 chr16:69928639 G/A cg00738113 chr16:70207722 CLEC18C -0.35 -6.05 -0.32 3.97e-9 Menarche (age at onset); CRC cis rs875971 1.000 rs1981798 chr7:65954903 G/T cg12463550 chr7:65579703 CRCP 0.49 6.88 0.35 3.08e-11 Aortic root size; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg03512643 chr14:74486160 C14orf45;ENTPD5 -0.4 -6.17 -0.32 1.99e-9 Myopia (pathological); CRC cis rs68170813 0.605 rs4730227 chr7:106904031 G/C cg02696742 chr7:106810147 HBP1 -0.63 -7.01 -0.36 1.32e-11 Coronary artery disease; CRC cis rs9894429 0.546 rs55917554 chr17:79608776 T/C cg21984481 chr17:79567631 NPLOC4 -0.48 -8.68 -0.43 1.83e-16 Eye color traits; CRC cis rs2455601 0.766 rs1109304 chr11:8955455 A/G cg09997546 chr11:8931473 C11orf17;ST5 -0.52 -6.96 -0.36 1.8e-11 Schizophrenia; CRC cis rs6426558 0.537 rs12039370 chr1:227326472 A/G cg10327440 chr1:227177885 CDC42BPA -0.47 -6.96 -0.36 1.88e-11 Neutrophil percentage of white cells; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg03003858 chr8:128747873 MYC 0.39 6.49 0.34 3.21e-10 Liver disease severity in Alagille syndrome; CRC cis rs4909189 0.915 rs11773551 chr7:158136146 C/T cg06219351 chr7:158114137 PTPRN2 -0.6 -8.23 -0.41 4.32e-15 Response to amphetamines; CRC cis rs72730918 0.564 rs4774594 chr15:51851999 C/T cg14296394 chr15:51910925 DMXL2 -0.45 -5.95 -0.31 6.86e-9 Intelligence (multi-trait analysis); CRC cis rs7605378 1.000 rs10194076 chr2:200677663 T/C cg17644776 chr2:200775616 C2orf69 0.4 5.77 0.3 1.86e-8 Osteoporosis; CRC cis rs10504229 0.728 rs17215621 chr8:58152706 C/A cg02725872 chr8:58115012 NA -0.57 -9.07 -0.45 1.09e-17 Developmental language disorder (linguistic errors); CRC cis rs11148252 0.669 rs61958050 chr13:52994427 A/C cg02158880 chr13:53174818 NA 0.49 6.82 0.35 4.44e-11 Lewy body disease; CRC cis rs4631830 0.720 rs12412140 chr10:51503977 T/C cg20129853 chr10:51489980 NA 0.35 5.86 0.31 1.13e-8 Prostate-specific antigen levels; CRC cis rs3741404 0.560 rs2875748 chr11:63915537 G/A cg05016508 chr11:63871570 FLRT1;MACROD1 -0.38 -5.78 -0.3 1.77e-8 Platelet count; CRC cis rs6580110 0.837 rs749777 chr5:154074270 T/C cg11923914 chr5:154071666 NA -0.47 -7.12 -0.37 6.73e-12 Facial morphology (factor 9, facial height related to vertical position of nasion); CRC cis rs477692 0.905 rs4751106 chr10:131424653 G/T cg05714579 chr10:131428358 MGMT -0.63 -9.13 -0.45 7e-18 Response to temozolomide; CRC cis rs9914988 0.887 rs11656272 chr17:27091153 A/G cg20469991 chr17:27169893 C17orf63 -0.6 -7.26 -0.37 2.76e-12 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs798554 0.679 rs2533868 chr7:2886559 G/A cg13628971 chr7:2884303 GNA12 0.62 8.87 0.44 4.82e-17 Height; CRC cis rs2762353 0.902 rs3799344 chr6:25786993 C/T cg03517284 chr6:25882590 NA 0.43 6.28 0.33 1.09e-9 Blood metabolite levels; CRC cis rs11992186 0.597 rs77717027 chr8:8591632 T/C cg06636001 chr8:8085503 FLJ10661 -0.44 -6.27 -0.33 1.12e-9 Neuroticism; CRC cis rs477895 0.653 rs12797120 chr11:63906819 C/T cg19465662 chr11:63993652 NUDT22;TRPT1 0.73 8.97 0.44 2.22e-17 Mean platelet volume; CRC cis rs919433 0.783 rs3097383 chr2:198236887 A/G cg03934865 chr2:198174659 NA 0.36 5.82 0.31 1.42e-8 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC cis rs9611519 0.929 rs12484971 chr22:41439304 A/T cg03806693 chr22:41940476 POLR3H -0.58 -7.45 -0.38 8.28e-13 Neuroticism; CRC cis rs7811142 0.830 rs73401443 chr7:99977582 T/G cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.61 8.11 0.41 1.03e-14 Platelet count; CRC cis rs10883723 0.737 rs11191312 chr10:104278601 T/C cg11453585 chr10:104263688 ACTR1A;SUFU 0.87 14.84 0.63 1.67e-38 Allergic disease (asthma, hay fever or eczema); CRC cis rs11608355 1.000 rs11608355 chr12:109879292 T/C cg19025524 chr12:109796872 NA -0.48 -6.88 -0.35 2.99e-11 Neuroticism; CRC cis rs12760731 0.511 rs6697878 chr1:178611238 G/T cg00404053 chr1:178313656 RASAL2 -0.54 -6.71 -0.35 8.43e-11 Obesity-related traits; CRC cis rs929354 0.742 rs886677 chr7:157003782 T/A cg17757837 chr7:157058334 UBE3C 0.74 12.62 0.57 4.92e-30 Body mass index; CRC cis rs12893668 0.543 rs12147645 chr14:104100208 T/A cg01849466 chr14:104193079 ZFYVE21 -0.42 -6.19 -0.32 1.83e-9 Reticulocyte count; CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg15531788 chr10:38146671 ZNF248 0.41 6.87 0.35 3.21e-11 Obesity-related traits; CRC cis rs539514 0.690 rs34545980 chr13:76309637 C/A cg04757411 chr13:76259545 LMO7 -0.35 -5.95 -0.31 6.88e-9 Type 1 diabetes; CRC cis rs9467711 0.606 rs28362606 chr6:26365586 T/C cg16898833 chr6:26189333 HIST1H4D 0.77 6.59 0.34 1.77e-10 Autism spectrum disorder or schizophrenia; CRC cis rs28386778 0.897 rs2854208 chr17:61946885 C/T cg06601766 chr17:61851465 DDX42;CCDC47 0.44 5.92 0.31 7.92e-9 Prudent dietary pattern; CRC cis rs6761276 1.000 rs6761276 chr2:113832312 C/T cg24553058 chr2:113831203 IL1F10 -0.42 -7.04 -0.36 1.14e-11 Protein quantitative trait loci; CRC cis rs78077440 1.000 rs57993951 chr5:40344787 A/T cg09067459 chr5:40385259 NA -0.53 -5.76 -0.3 1.95e-8 Multiple sclerosis; CRC cis rs2479724 0.792 rs7739064 chr6:41834037 C/A cg17623882 chr6:41773611 USP49 -0.55 -9.38 -0.46 1.14e-18 Menarche (age at onset); CRC cis rs9560113 1.000 rs4773383 chr13:112177764 C/T cg10483660 chr13:112241077 NA 0.36 5.82 0.31 1.39e-8 Menarche (age at onset); CRC cis rs7647973 1.000 rs56127630 chr3:49438036 C/G cg20833759 chr3:49053208 WDR6;DALRD3 -0.56 -8.31 -0.42 2.49e-15 Menarche (age at onset); CRC cis rs8180040 0.764 rs62246375 chr3:47014464 G/A cg10298567 chr3:47292165 KIF9 0.37 5.85 0.31 1.16e-8 Colorectal cancer; CRC cis rs9462846 0.725 rs6927188 chr6:42912589 C/T cg21280719 chr6:42927975 GNMT 0.37 6.43 0.33 4.38e-10 Blood protein levels; CRC cis rs35110281 0.782 rs6518302 chr21:45018478 A/G cg01579765 chr21:45077557 HSF2BP -0.38 -7.33 -0.37 1.77e-12 Mean corpuscular volume; CRC cis rs875971 0.862 rs2088653 chr7:65808608 G/A cg18876405 chr7:65276391 NA -0.53 -8.59 -0.43 3.58e-16 Aortic root size; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg13654993 chr19:5978414 RANBP3 0.41 6.13 0.32 2.47e-9 Intelligence (multi-trait analysis); CRC cis rs10479542 0.766 rs6894980 chr5:178974592 C/T cg00080972 chr5:178986291 RUFY1 0.33 6.08 0.32 3.28e-9 Lung cancer; CRC cis rs7605827 0.930 rs11680044 chr2:15607103 T/G cg19274914 chr2:15703543 NA 0.39 5.9 0.31 8.83e-9 Educational attainment (years of education); CRC cis rs4629180 0.675 rs6707298 chr2:102089738 A/G cg01388757 chr2:102091195 RFX8 0.35 5.87 0.31 1.09e-8 Chronic rhinosinusitis with nasal polyps; CRC cis rs926392 0.572 rs6129159 chr20:37675011 A/T cg16355469 chr20:37678765 NA 0.5 7.41 0.38 1.09e-12 Dialysis-related mortality; CRC cis rs2115630 0.846 rs8024538 chr15:85368419 A/T cg12501888 chr15:85177176 SCAND2 -0.37 -5.87 -0.31 1.07e-8 P wave terminal force; CRC cis rs10876993 0.890 rs7963927 chr12:58046272 T/G cg15848620 chr12:58087721 OS9 -0.61 -8.35 -0.42 1.98e-15 Celiac disease or Rheumatoid arthritis; CRC cis rs9467603 1.000 rs6939997 chr6:25821224 C/T cg16898833 chr6:26189333 HIST1H4D 0.77 6.45 0.33 4.07e-10 Intelligence (multi-trait analysis); CRC cis rs9814567 1.000 rs9832785 chr3:134213070 A/G cg06109529 chr3:134205091 CEP63;ANAPC13 -0.81 -12.37 -0.56 4.1e-29 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs7216064 0.953 rs11868959 chr17:65840810 T/C cg12091567 chr17:66097778 LOC651250 -0.68 -7.87 -0.4 5.31e-14 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CRC cis rs9467711 0.559 rs2295593 chr6:26501768 C/T cg16898833 chr6:26189333 HIST1H4D 0.79 6.92 0.36 2.35e-11 Autism spectrum disorder or schizophrenia; CRC cis rs7618915 0.571 rs2251219 chr3:52584787 C/T cg05573699 chr3:52720067 GNL3;PBRM1 0.41 5.65 0.3 3.49e-8 Bipolar disorder; CRC trans rs2727020 0.619 rs11040300 chr11:49269984 C/A cg11707556 chr5:10655725 ANKRD33B 0.39 6.32 0.33 8.46e-10 Coronary artery disease; CRC cis rs9914988 0.943 rs4313850 chr17:27080768 T/C cg16670446 chr17:27188758 MIR451;MIR144 0.53 8.34 0.42 2.05e-15 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs7811142 0.830 rs76798830 chr7:99952828 C/T cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.71 9.16 0.45 5.66e-18 Platelet count; CRC trans rs561341 0.825 rs2008368 chr17:30347397 T/C cg20587970 chr11:113659929 NA -1.4 -19.73 -0.74 1.03e-57 Hip circumference adjusted for BMI; CRC trans rs1814175 0.817 rs28544182 chr11:50049577 G/T cg11707556 chr5:10655725 ANKRD33B -0.43 -8.37 -0.42 1.72e-15 Height; CRC cis rs1348850 0.874 rs13013752 chr2:178456862 A/G cg22681709 chr2:178499509 PDE11A -0.32 -5.9 -0.31 8.96e-9 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs1862618 0.853 rs10051747 chr5:56083289 C/A cg20203395 chr5:56204925 C5orf35 -0.74 -8.73 -0.43 1.32e-16 Initial pursuit acceleration; CRC cis rs4073582 0.516 rs1151539 chr11:66031660 C/T cg14036092 chr11:66035641 RAB1B 0.57 9.24 0.45 3.19e-18 Gout; CRC cis rs8060686 0.641 rs8059305 chr16:68036666 A/C cg08314208 chr16:67682810 RLTPR -0.49 -6.08 -0.32 3.35e-9 HDL cholesterol;Metabolic syndrome; CRC cis rs854572 0.600 rs705382 chr7:94955221 C/G cg19678392 chr7:94953810 PON1 -0.73 -12.44 -0.57 2.22e-29 Paraoxonase activity; CRC cis rs2251381 0.778 rs2245021 chr21:30546841 C/T cg08807101 chr21:30365312 RNF160 0.66 9.83 0.48 3.8e-20 Selective IgA deficiency; CRC cis rs6121246 0.529 rs58757492 chr20:30181425 G/A cg13852791 chr20:30311386 BCL2L1 0.59 8.11 0.41 1.01e-14 Mean corpuscular hemoglobin; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg13285458 chr12:49212305 CACNB3 0.4 6.29 0.33 1.02e-9 Liver disease severity in Alagille syndrome; CRC cis rs875971 1.000 rs1363055 chr7:65943275 A/G cg11764359 chr7:65958608 NA 0.62 9.91 0.48 1.96e-20 Aortic root size; CRC trans rs6550704 0.687 rs9865314 chr3:22634337 A/G cg10473508 chr5:172068142 NEURL1B -0.42 -6.26 -0.33 1.22e-9 Daytime sleep phenotypes; CRC cis rs7940866 0.809 rs11222410 chr11:130833994 A/G cg12179176 chr11:130786555 SNX19 0.57 8.33 0.42 2.21e-15 Schizophrenia; CRC cis rs6502050 0.835 rs9902485 chr17:80093701 C/T cg11859384 chr17:80120422 CCDC57 -0.37 -5.94 -0.31 7.25e-9 Life satisfaction; CRC trans rs948562 1.000 rs111901203 chr11:58297542 C/T cg26660744 chr1:1573181 CDK11B 0.53 6.2 0.32 1.69e-9 Lymphoma; CRC trans rs208520 0.739 rs1935894 chr6:66891434 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.91 -12.38 -0.56 3.59e-29 Exhaled nitric oxide output; CRC cis rs9910055 0.664 rs433610 chr17:42197281 A/G cg13607699 chr17:42295918 UBTF -0.53 -7.32 -0.37 1.96e-12 Total body bone mineral density; CRC cis rs2836974 0.899 rs34176878 chr21:40548855 C/A cg11644478 chr21:40555479 PSMG1 0.82 12.6 0.57 5.59e-30 Cognitive function; CRC cis rs8077889 0.871 rs8065043 chr17:41900984 G/A cg26893861 chr17:41843967 DUSP3 0.92 13.52 0.6 2.02e-33 Triglycerides; CRC cis rs3768617 0.811 rs10911205 chr1:183009277 C/A ch.1.3577855R chr1:183094577 LAMC1 0.61 9.01 0.45 1.67e-17 Fuchs's corneal dystrophy; CRC cis rs1448094 0.511 rs34656916 chr12:86154658 G/C cg06740227 chr12:86229804 RASSF9 0.38 5.7 0.3 2.73e-8 Major depressive disorder; CRC cis rs300703 0.872 rs7568288 chr2:276908 C/G cg21211680 chr2:198530 NA 0.97 8.48 0.42 7.89e-16 Blood protein levels; CRC cis rs9847710 0.733 rs7613013 chr3:53077806 A/G cg18099408 chr3:52552593 STAB1 0.4 5.85 0.31 1.16e-8 Ulcerative colitis; CRC cis rs3806843 0.750 rs2563285 chr5:140126137 T/C cg19875535 chr5:140030758 IK -0.55 -8.86 -0.44 5.08e-17 Depressive symptoms (multi-trait analysis); CRC cis rs7618915 0.501 rs3774366 chr3:52641255 T/C cg18099408 chr3:52552593 STAB1 -0.47 -8.12 -0.41 9.25e-15 Bipolar disorder; CRC cis rs1534166 0.601 rs13324779 chr3:133510413 G/A cg08048268 chr3:133502702 NA 0.41 7.2 0.37 4.24e-12 Alcohol consumption (transferrin glycosylation); CRC cis rs11166629 1.000 rs2873014 chr8:135645860 C/T cg27224718 chr8:135614730 ZFAT -0.5 -7.35 -0.38 1.54e-12 Smoking quantity; CRC cis rs9635726 0.638 rs2952155 chr17:37861718 T/C cg00129232 chr17:37814104 STARD3 -0.67 -9.99 -0.48 1.09e-20 Primary biliary cholangitis; CRC cis rs4481887 0.741 rs28616194 chr1:248531904 T/A cg26353448 chr1:248524236 OR2T4 -0.35 -6.68 -0.35 1.02e-10 Common traits (Other); CRC cis rs9549367 0.713 rs556990 chr13:113845059 T/C cg18105134 chr13:113819100 PROZ 0.85 13.44 0.6 3.84e-33 Platelet distribution width; CRC cis rs2630709 0.541 rs3102957 chr2:8465395 G/A cg12167548 chr2:8464763 NA 0.35 6.8 0.35 4.98e-11 Monocyte percentage of white cells; CRC cis rs9611565 0.559 rs132771 chr22:42025350 A/G cg03806693 chr22:41940476 POLR3H 1.01 12.62 0.57 4.94e-30 Vitiligo; CRC cis rs908922 0.676 rs4845784 chr1:152494583 G/C cg23254163 chr1:152506842 NA 0.49 9.8 0.48 4.6e-20 Hair morphology; CRC cis rs7044106 0.762 rs1470307 chr9:123433039 A/G cg14255062 chr9:123606675 PSMD5;LOC253039 0.43 6.59 0.34 1.7e-10 Hip circumference adjusted for BMI; CRC cis rs2243480 0.901 rs1701759 chr7:65470932 G/T cg18252515 chr7:66147081 NA -1.06 -12.27 -0.56 9.34e-29 Diabetic kidney disease; CRC trans rs11031096 0.641 rs232054 chr11:4123427 C/G cg22978087 chr8:24814126 NEFL 0.32 6.01 0.31 4.93e-9 Mean corpuscular volume;Mean corpuscular hemoglobin; CRC cis rs72945132 0.882 rs7943840 chr11:70228615 C/A cg00319359 chr11:70116639 PPFIA1 0.55 6.0 0.31 5.18e-9 Coronary artery disease; CRC cis rs12497850 1.000 rs4858798 chr3:48727112 C/T cg07636037 chr3:49044803 WDR6 0.93 15.88 0.66 1.49e-42 Parkinson's disease; CRC trans rs3733585 0.578 rs4466042 chr4:9955367 T/C cg26043149 chr18:55253948 FECH -0.5 -7.78 -0.39 9.21e-14 Cleft plate (environmental tobacco smoke interaction); CRC cis rs17023223 0.537 rs12085308 chr1:119677553 T/C cg05756136 chr1:119680316 WARS2 -0.54 -7.39 -0.38 1.2e-12 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for BMI in active individuals; CRC trans rs9747201 0.925 rs11867806 chr17:80072049 A/G cg07393940 chr7:158741817 NA -0.53 -7.63 -0.39 2.61e-13 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs826838 0.967 rs1719852 chr12:39128531 A/G cg26384229 chr12:38710491 ALG10B -0.64 -9.71 -0.47 9.26e-20 Heart rate; CRC cis rs3749237 0.964 rs62260719 chr3:49852419 G/A cg24308560 chr3:49941425 MST1R -0.39 -5.61 -0.3 4.41e-8 Resting heart rate; CRC cis rs10752881 1.000 rs10797802 chr1:182973158 A/T ch.1.3577855R chr1:183094577 LAMC1 -0.85 -14.8 -0.63 2.43e-38 Colorectal cancer; CRC cis rs6570726 0.791 rs385729 chr6:145855465 T/C cg05347473 chr6:146136440 FBXO30 0.39 5.92 0.31 8.19e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs791888 0.858 rs2180968 chr10:89418730 A/C cg13926569 chr10:89418898 PAPSS2 0.49 7.24 0.37 3.18e-12 Magnesium levels; CRC cis rs6499255 0.951 rs3169315 chr16:69720964 G/A cg15192750 chr16:69999425 NA 0.47 6.56 0.34 2.07e-10 IgE levels; CRC cis rs2602836 0.830 rs2602874 chr4:100039396 A/T cg12011299 chr4:100065546 ADH4 0.63 15.61 0.65 1.67e-41 HDL cholesterol;HDL cholesterol levels; CRC cis rs9858542 0.953 rs35115732 chr3:49475155 T/C cg07274523 chr3:49395745 GPX1 0.48 6.55 0.34 2.2e-10 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC trans rs2898857 0.545 rs12942379 chr17:47358733 C/T cg11430096 chr6:110968061 CDK19 0.51 7.8 0.4 8.44e-14 Cancer; CRC cis rs4713675 0.546 rs10947434 chr6:33691501 G/T cg14003231 chr6:33640908 ITPR3 0.52 8.41 0.42 1.24e-15 Plateletcrit; CRC cis rs736408 0.509 rs1108842 chr3:52720080 A/C cg08222913 chr3:52553049 STAB1 -0.38 -7.43 -0.38 9.54e-13 Bipolar disorder; CRC cis rs9649465 0.967 rs1008539 chr7:123305518 G/A cg03229431 chr7:123269106 ASB15 -0.37 -5.71 -0.3 2.56e-8 Migraine; CRC cis rs524281 0.647 rs2302883 chr11:65824994 T/C cg16950941 chr11:66035639 RAB1B -0.54 -7.17 -0.37 4.89e-12 Electroencephalogram traits; CRC cis rs28386778 0.897 rs894407 chr17:61901641 T/C cg06601766 chr17:61851465 DDX42;CCDC47 0.44 5.96 0.31 6.33e-9 Prudent dietary pattern; CRC cis rs34779708 0.897 rs34481177 chr10:35380913 C/T cg03585969 chr10:35415529 CREM 0.67 8.87 0.44 4.78e-17 Inflammatory bowel disease;Crohn's disease; CRC cis rs11895698 1 rs11895698 chr2:239338495 C/T cg18131467 chr2:239335373 ASB1 -0.69 -7.45 -0.38 8.18e-13 Chronotype; CRC cis rs524023 1.000 rs524023 chr11:64358265 C/T cg06522879 chr11:64358276 SLC22A12 0.57 8.95 0.44 2.62e-17 Urate levels in obese individuals; CRC cis rs2573652 1.000 rs12441080 chr15:100516968 A/G cg00587665 chr15:100533223 ADAMTS17 0.34 5.76 0.3 1.9e-8 Height; CRC cis rs17095355 0.605 rs7916801 chr10:111632445 A/G cg00817464 chr10:111662876 XPNPEP1 0.43 5.76 0.3 1.92e-8 Biliary atresia; CRC cis rs9322193 0.962 rs4869730 chr6:150129323 A/G cg13206674 chr6:150067644 NUP43 0.56 7.9 0.4 4.25e-14 Lung cancer; CRC cis rs7119 0.667 rs2867312 chr15:77902293 A/G cg27398640 chr15:77910606 LINGO1 -0.44 -8.26 -0.41 3.66e-15 Type 2 diabetes; CRC cis rs1552244 1.000 rs6414438 chr3:10073824 G/C cg13047869 chr3:10149882 C3orf24 0.52 7.2 0.37 4.24e-12 Alzheimer's disease; CRC trans rs9858542 1.000 rs1131095 chr3:49714225 T/C cg21582582 chr3:182698605 DCUN1D1 -0.55 -6.56 -0.34 2.05e-10 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs514406 0.929 rs557715 chr1:53321593 C/G cg27535305 chr1:53392650 SCP2 -0.37 -6.91 -0.36 2.52e-11 Monocyte count; CRC cis rs6545883 0.965 rs3771258 chr2:61764140 C/T cg15711740 chr2:61764176 XPO1 -0.52 -7.25 -0.37 3e-12 Tuberculosis; CRC cis rs7666738 0.962 rs1527515 chr4:99025733 C/A cg03676636 chr4:99064102 C4orf37 0.25 6.97 0.36 1.78e-11 Colonoscopy-negative controls vs population controls; CRC cis rs4972806 0.814 rs4246626 chr2:177046430 A/C cg09355771 chr2:177043147 NA 0.71 11.02 0.52 3.14e-24 IgG glycosylation; CRC cis rs9682041 0.627 rs11924474 chr3:170091333 T/G cg11886554 chr3:170076028 SKIL 0.63 7.83 0.4 6.75e-14 Glomerular filtration rate in non diabetics (creatinine);Glomerular filtration rate (creatinine); CRC cis rs67478160 0.643 rs8003653 chr14:104298836 A/G cg01849466 chr14:104193079 ZFYVE21 -0.47 -8.36 -0.42 1.78e-15 Schizophrenia; CRC cis rs11650494 0.908 rs77338752 chr17:47372328 A/C cg08112188 chr17:47440006 ZNF652 1.2 10.88 0.51 9.18e-24 Prostate cancer; CRC cis rs425277 1.000 rs262676 chr1:2078482 T/A cg24578937 chr1:2090814 PRKCZ 0.66 11.79 0.54 5.46e-27 Height; CRC cis rs9549328 0.670 rs3011475 chr13:113616866 T/C cg25790453 chr13:113633590 MCF2L 0.44 7.57 0.38 3.91e-13 Systolic blood pressure; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg14122300 chr14:69446504 ACTN1 0.46 6.98 0.36 1.68e-11 Response to antipsychotic treatment; CRC cis rs62064224 0.714 rs4794917 chr17:30636146 C/G cg09324608 chr17:30823087 MYO1D 0.36 6.31 0.33 9.25e-10 Schizophrenia; CRC cis rs1799949 0.930 rs8176194 chr17:41231221 A/C cg25072359 chr17:41440525 NA 0.44 6.5 0.34 2.98e-10 Menopause (age at onset); CRC cis rs2204008 0.837 rs11169157 chr12:37980047 T/C cg26384229 chr12:38710491 ALG10B 0.67 9.3 0.46 2.04e-18 Bladder cancer; CRC cis rs3823572 0.525 rs28588750 chr7:133629138 A/G cg03336402 chr7:133662267 EXOC4 0.63 9.64 0.47 1.5700000000000001e-19 Intelligence (multi-trait analysis); CRC cis rs7835763 0.692 rs2445905 chr8:119104646 T/C cg11592677 chr8:119110466 EXT1 -0.37 -6.05 -0.32 3.97e-9 Autism spectrum disorder; CRC cis rs1223397 0.938 rs3734878 chr6:13288850 C/T cg07912922 chr6:13274314 PHACTR1 0.54 6.43 0.33 4.36e-10 Blood pressure; CRC trans rs3733585 0.806 rs11723382 chr4:9954660 T/C cg26043149 chr18:55253948 FECH -0.53 -8.23 -0.41 4.53e-15 Cleft plate (environmental tobacco smoke interaction); CRC cis rs7917772 0.505 rs61869211 chr10:104449836 A/G cg22532475 chr10:104410764 TRIM8 -0.42 -6.82 -0.35 4.26e-11 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC cis rs2075371 0.966 rs722657 chr7:133994956 T/C cg20476274 chr7:133979776 SLC35B4 0.8 14.34 0.62 1.44e-36 Mean platelet volume; CRC cis rs6460942 0.544 rs73287160 chr7:12143582 T/C cg06484146 chr7:12443880 VWDE -0.47 -5.81 -0.3 1.49e-8 Coronary artery disease; CRC cis rs11690935 0.550 rs6730085 chr2:172864845 C/A cg13550731 chr2:172543902 DYNC1I2 0.64 9.19 0.45 4.43e-18 Schizophrenia; CRC cis rs2576037 0.583 rs644731 chr18:44426877 C/T cg19077165 chr18:44547161 KATNAL2 -0.62 -10.64 -0.51 6.35e-23 Personality dimensions; CRC cis rs1223397 0.651 rs2496140 chr6:13309895 A/T cg07912922 chr6:13274314 PHACTR1 0.4 6.28 0.33 1.07e-9 Blood pressure; CRC cis rs2180341 0.618 rs11961994 chr6:127649350 A/G cg27446573 chr6:127587934 RNF146 -0.62 -9.31 -0.46 1.85e-18 Breast cancer; CRC cis rs780096 0.565 rs780104 chr2:27677691 G/A cg24768116 chr2:27665128 KRTCAP3 -0.36 -8.12 -0.41 9.76e-15 Total body bone mineral density; CRC cis rs853679 0.723 rs9366718 chr6:28205502 A/T cg12273811 chr6:28175739 NA 0.54 5.79 0.3 1.62e-8 Depression; CRC trans rs6762477 0.715 rs12631337 chr3:50198537 A/G cg21665057 chr3:196295764 WDR53;FBXO45 -0.43 -6.4 -0.33 5.33e-10 Menarche (age at onset); CRC trans rs2727020 0.553 rs10839295 chr11:49527345 A/C cg15704280 chr7:45808275 SEPT13 -0.95 -17.98 -0.7 7.96e-51 Coronary artery disease; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg26815021 chr17:74733172 MIR636;MFSD11;SFRS2 0.45 6.9 0.36 2.73e-11 Liver disease severity in Alagille syndrome; CRC cis rs9926296 0.581 rs12598477 chr16:89902482 T/C cg04287289 chr16:89883240 FANCA 0.61 9.57 0.47 2.75e-19 Vitiligo; CRC cis rs6121246 0.821 rs115585940 chr20:30317902 T/C cg13852791 chr20:30311386 BCL2L1 0.67 10.38 0.5 4.94e-22 Mean corpuscular hemoglobin; CRC trans rs7615952 0.546 rs2976733 chr3:125414138 T/C cg02560186 chr11:3602584 NA -0.63 -9.62 -0.47 1.78e-19 Blood pressure (smoking interaction); CRC cis rs4975709 0.589 rs4975747 chr5:1862836 G/A cg11168104 chr5:1857477 NA -0.37 -6.41 -0.33 4.99e-10 Cardiovascular disease risk factors; CRC cis rs782590 0.935 rs10460508 chr2:55882565 A/C cg18811423 chr2:55921094 PNPT1 0.83 15.85 0.66 1.97e-42 Metabolic syndrome; CRC cis rs477895 0.713 rs12575642 chr11:63979643 G/T cg05016508 chr11:63871570 FLRT1;MACROD1 0.53 6.8 0.35 5.05e-11 Mean platelet volume; CRC cis rs3736485 0.966 rs17609917 chr15:51911487 G/C cg08986416 chr15:51914746 DMXL2 -0.45 -6.33 -0.33 8.13e-10 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs1401999 0.628 rs6798870 chr3:183740350 G/A cg20387954 chr3:183756860 HTR3D 0.37 6.45 0.34 3.92e-10 Anterior chamber depth; CRC cis rs9894429 0.966 rs10871499 chr17:79589006 G/A cg21028142 chr17:79581711 NPLOC4 0.39 8.62 0.43 2.89e-16 Eye color traits; CRC cis rs1552244 0.816 rs13076197 chr3:10019773 T/C cg16606324 chr3:10149918 C3orf24 0.61 7.98 0.4 2.47e-14 Alzheimer's disease; CRC cis rs1348850 0.918 rs12622298 chr2:178450651 C/T cg22681709 chr2:178499509 PDE11A -0.31 -5.9 -0.31 9.14e-9 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs8060686 0.641 rs7201742 chr16:68099821 T/G cg08314208 chr16:67682810 RLTPR -0.49 -5.94 -0.31 7.19e-9 HDL cholesterol;Metabolic syndrome; CRC cis rs9467711 0.606 rs9393710 chr6:26367833 A/G cg14345882 chr6:26364793 BTN3A2 0.65 5.74 0.3 2.17e-8 Autism spectrum disorder or schizophrenia; CRC cis rs57221529 0.766 rs72703065 chr5:588123 C/A cg16447950 chr5:562315 NA -0.81 -10.62 -0.51 7.76e-23 Lung disease severity in cystic fibrosis; CRC trans rs2228479 0.702 rs17233253 chr16:89828437 A/G cg24644049 chr4:85504048 CDS1 0.86 6.93 0.36 2.29e-11 Skin colour saturation; CRC cis rs2115630 0.905 rs6496401 chr15:85297793 A/T cg11189052 chr15:85197271 WDR73 -0.63 -10.17 -0.49 2.66e-21 P wave terminal force; CRC cis rs9463078 0.764 rs9367211 chr6:44885305 T/C cg25276700 chr6:44698697 NA -0.26 -6.36 -0.33 6.63e-10 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; CRC cis rs9491140 0.539 rs980656 chr6:124690303 A/G cg05308643 chr6:124982296 NKAIN2 0.48 6.74 0.35 7.01e-11 Neuroticism; CRC cis rs72781680 0.846 rs72780198 chr2:24014883 T/A cg08917208 chr2:24149416 ATAD2B 0.84 8.11 0.41 1e-14 Lymphocyte counts; CRC cis rs9992667 0.955 rs11937257 chr4:38645460 A/G cg19726192 chr4:38663646 FLJ13197 -0.67 -8.69 -0.43 1.74e-16 Eosinophil percentage of granulocytes; CRC cis rs1552244 0.554 rs6443275 chr3:10008819 G/A cg16606324 chr3:10149918 C3orf24 0.47 7.1 0.36 7.81e-12 Alzheimer's disease; CRC cis rs11229555 1.000 rs2275993 chr11:58379987 A/G cg15696309 chr11:58395628 NA -0.95 -13.36 -0.59 7.99e-33 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; CRC cis rs4750440 0.706 rs11258770 chr10:14018910 G/T cg00551146 chr10:14014579 FRMD4A 0.36 5.88 0.31 9.87e-9 Adiponectin levels; CRC cis rs2257205 0.667 rs7221142 chr17:56758786 A/G cg25885038 chr17:56607967 SEPT4 -0.52 -5.69 -0.3 2.87e-8 Pancreatic cancer; CRC cis rs10140922 0.931 rs4982261 chr14:35822159 C/T cg07166546 chr14:35805898 NA -0.3 -5.89 -0.31 9.79e-9 Hip circumference adjusted for BMI; CRC cis rs4664293 0.669 rs1863219 chr2:160418171 C/G cg08347373 chr2:160653686 CD302 0.41 6.97 0.36 1.7e-11 Monocyte percentage of white cells; CRC cis rs7918232 0.941 rs4749230 chr10:27441218 C/T cg14442939 chr10:27389572 ANKRD26 0.82 9.11 0.45 7.99e-18 Breast cancer; CRC cis rs6582630 0.555 rs11503799 chr12:38294578 G/A cg26384229 chr12:38710491 ALG10B -0.52 -7.48 -0.38 6.93e-13 Drug-induced liver injury (flucloxacillin); CRC cis rs2882667 0.858 rs13176497 chr5:138446074 T/C cg04439458 chr5:138467593 SIL1 -0.36 -6.06 -0.32 3.77e-9 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs6570726 0.934 rs430003 chr6:145819506 C/T cg05347473 chr6:146136440 FBXO30 0.37 6.0 0.31 5.27e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs2228479 0.850 rs11649510 chr16:89851004 A/G cg06558623 chr16:89946397 TCF25 1.12 10.46 0.5 2.76e-22 Skin colour saturation; CRC cis rs597539 0.652 rs559032 chr11:68710847 G/T cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.87 14.93 0.64 7.62e-39 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs2204008 0.702 rs3849999 chr12:38483498 G/A cg13010199 chr12:38710504 ALG10B -0.41 -5.89 -0.31 9.38e-9 Bladder cancer; CRC cis rs2629540 0.889 rs4962402 chr10:126459114 T/G cg08799069 chr10:126477246 METTL10 -0.62 -8.62 -0.43 2.94e-16 Cocaine dependence; CRC trans rs12517041 1.000 rs7734279 chr5:23300161 G/A ch.8.1293020R chr8:59333349 UBXN2B -0.56 -6.2 -0.32 1.74e-9 Calcium levels; CRC cis rs6547741 0.935 rs56001553 chr2:27859926 C/T cg27432699 chr2:27873401 GPN1 -0.77 -13.66 -0.6 5.96e-34 Oral cavity cancer; CRC trans rs2303319 0.504 rs62189054 chr2:162624654 C/G cg13490827 chr1:46269305 MAST2 -0.68 -5.99 -0.31 5.44e-9 Cognitive function; CRC cis rs4073416 0.508 rs7140341 chr14:66070417 C/G cg03016385 chr14:66212404 NA -0.45 -6.17 -0.32 2.05e-9 N-glycan levels; CRC cis rs7615952 0.932 rs9841157 chr3:125635655 C/A cg05084668 chr3:125655381 ALG1L -0.62 -8.37 -0.42 1.71e-15 Blood pressure (smoking interaction); CRC cis rs3741151 0.686 rs61516411 chr11:73302768 T/C cg17517138 chr11:73019481 ARHGEF17 0.57 5.84 0.31 1.25e-8 GIP levels in response to oral glucose tolerance test (120 minutes); CRC cis rs34779708 0.931 rs13376871 chr10:35369056 A/G cg03585969 chr10:35415529 CREM 0.57 7.61 0.39 2.94e-13 Inflammatory bowel disease;Crohn's disease; CRC cis rs2732480 0.500 rs1387257 chr12:48636666 C/A cg21466736 chr12:48725269 NA -0.54 -8.07 -0.41 1.29e-14 Hemoglobin concentration;Red blood cell count;Hematocrit; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg07596845 chr6:82957841 IBTK 0.43 6.11 0.32 2.74e-9 Response to antipsychotic treatment; CRC cis rs1552244 1.000 rs56270432 chr3:10087517 G/C cg16606324 chr3:10149918 C3orf24 0.7 9.64 0.47 1.61e-19 Alzheimer's disease; CRC cis rs7113874 0.589 rs9705253 chr11:8596483 A/T cg20771178 chr11:8615675 STK33 -0.35 -5.72 -0.3 2.42e-8 Body mass index in physically active individuals;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs7208859 0.673 rs999796 chr17:29159404 G/C cg14008862 chr17:28927542 LRRC37B2 0.51 6.17 0.32 2.06e-9 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs7394190 0.748 rs79936644 chr10:75545117 C/T cg07699608 chr10:75541558 CHCHD1 0.61 6.38 0.33 5.97e-10 Incident atrial fibrillation; CRC cis rs863345 0.604 rs1894040 chr1:158456336 C/T cg12129480 chr1:158549410 OR10X1 0.29 6.04 0.32 4.17e-9 Pneumococcal bacteremia; CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg22833807 chr22:36925177 EIF3D -0.52 -6.33 -0.33 8.17e-10 Diisocyanate-induced asthma; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg12726277 chr7:973190 ADAP1 -0.38 -6.45 -0.34 4e-10 Liver disease severity in Alagille syndrome; CRC cis rs2292096 0.850 rs6663728 chr1:200815179 G/A cg07580975 chr1:200843333 NA 0.46 6.3 0.33 9.69e-10 Epilepsy; CRC cis rs7829975 0.806 rs2428 chr8:8641145 C/T cg06636001 chr8:8085503 FLJ10661 0.61 10.16 0.49 2.82e-21 Mood instability; CRC cis rs6684514 1.000 rs12142808 chr1:156230546 G/A cg16558208 chr1:156270281 VHLL 0.62 9.75 0.47 6.96e-20 Mean corpuscular hemoglobin concentration;Glycated hemoglobin levels; CRC cis rs911119 0.955 rs8121283 chr20:23605002 G/C cg16589663 chr20:23618590 CST3 0.45 6.38 0.33 6.08e-10 Chronic kidney disease; CRC cis rs12024301 0.557 rs6681661 chr1:183605801 C/G cg11505048 chr1:183622726 RGL1;APOBEC4 0.77 6.73 0.35 7.45e-11 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs1003719 0.715 rs8130643 chr21:38551715 T/A cg10648535 chr21:38446584 PIGP;TTC3 -0.48 -6.72 -0.35 7.91e-11 Eye color traits; CRC cis rs887829 0.641 rs10167119 chr2:234589312 T/C cg07512295 chr2:234599026 UGT1A6;UGT1A10;UGT1A9;UGT1A7;UGT1A8 0.38 5.85 0.31 1.2e-8 Metabolic traits;Bilirubin levels;Cholelithiasis-related traits in sickle cell anemia;Metabolite levels;Total bilirubin levels in HIV-1 infection;Serum metabolite levels;Blood metabolite levels; CRC cis rs9894429 0.546 rs55917554 chr17:79608776 T/C cg09655341 chr17:79618100 PDE6G -0.38 -6.68 -0.35 1.02e-10 Eye color traits; CRC cis rs6502050 0.799 rs34448080 chr17:80121275 A/G cg19223190 chr17:80058835 NA 0.39 6.23 0.32 1.43e-9 Life satisfaction; CRC trans rs7267979 1.000 rs7267979 chr20:25298087 C/T cg17903999 chr18:56338584 MALT1 -0.44 -7.32 -0.37 1.9e-12 Liver enzyme levels (alkaline phosphatase); CRC cis rs10499694 0.967 rs7786398 chr7:50612906 G/A cg18232548 chr7:50535776 DDC -0.43 -6.38 -0.33 6.17e-10 Body mass index; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg19713609 chr11:819941 PNPLA2 -0.4 -6.18 -0.32 1.91e-9 Myopia (pathological); CRC cis rs807029 0.577 rs3740488 chr10:102754033 A/T cg04662943 chr10:102668895 NA 0.58 7.15 0.37 5.82e-12 Ejection fraction in Tripanosoma cruzi seropositivity; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg23753457 chr11:69455870 CCND1 0.48 6.23 0.32 1.46e-9 Thyroid stimulating hormone; CRC trans rs1941687 0.769 rs1493911 chr18:31356019 A/G cg27147174 chr7:100797783 AP1S1 -0.36 -6.05 -0.32 3.85e-9 Subjective well-being (multi-trait analysis);Subjective well-being; CRC cis rs4604732 0.578 rs7525209 chr1:247627404 C/T cg02104434 chr1:247694406 LOC148824;OR2C3 0.6 8.82 0.44 6.67e-17 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CRC trans rs7647973 0.626 rs7637711 chr3:49829653 A/G cg21659725 chr3:3221576 CRBN 0.61 6.85 0.35 3.71e-11 Menarche (age at onset); CRC cis rs3823572 0.525 rs2346443 chr7:133706383 C/T cg03336402 chr7:133662267 EXOC4 -0.65 -9.24 -0.45 3.1e-18 Intelligence (multi-trait analysis); CRC cis rs1448094 0.511 rs61930585 chr12:86158461 C/A cg25456477 chr12:86230367 RASSF9 0.4 6.57 0.34 2e-10 Major depressive disorder; CRC cis rs3820068 0.581 rs72645890 chr1:15930602 A/G cg24675056 chr1:15929824 NA 0.49 6.77 0.35 5.87e-11 Systolic blood pressure; CRC cis rs477895 0.713 rs2282490 chr11:63962152 T/C cg19465662 chr11:63993652 NUDT22;TRPT1 0.73 8.97 0.44 2.31e-17 Mean platelet volume; CRC cis rs6701037 0.566 rs1883102 chr1:175136793 T/A cg17845761 chr1:175162550 KIAA0040 0.3 6.4 0.33 5.2400000000000005e-10 Alcohol dependence; CRC cis rs1008375 1.000 rs28480159 chr4:17685707 A/C cg04450456 chr4:17643702 FAM184B 0.39 6.31 0.33 8.97e-10 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs7412746 0.658 rs72704685 chr1:150897687 C/G cg15448220 chr1:150897856 SETDB1 0.56 8.23 0.41 4.4e-15 Melanoma; CRC cis rs10806425 0.524 rs1394220 chr6:91019304 A/C cg06866423 chr6:90926672 BACH2 0.56 10.41 0.5 3.93e-22 Celiac disease; CRC cis rs2455601 0.608 rs59025804 chr11:8870301 T/C cg21881798 chr11:8931708 C11orf17;ST5 -0.51 -6.71 -0.35 8.48e-11 Schizophrenia; CRC cis rs35110281 0.811 rs9980185 chr21:45057905 A/G cg04455712 chr21:45112962 RRP1B 0.38 7.4 0.38 1.16e-12 Mean corpuscular volume; CRC cis rs847649 0.694 rs11770319 chr7:102770170 C/G cg18108683 chr7:102477205 FBXL13 0.52 8.32 0.42 2.3e-15 Morning vs. evening chronotype; CRC trans rs10506458 1.000 rs1495013 chr12:63428188 C/T cg03429785 chr15:59498649 MYO1E;LDHAL6B -1.36 -19.5 -0.73 7.78e-57 Hemostatic factors and hematological phenotypes; CRC cis rs28386778 0.830 rs2854210 chr17:61946338 C/A cg06873352 chr17:61820015 STRADA 0.77 14.65 0.63 9.65e-38 Prudent dietary pattern; CRC cis rs2463822 0.583 rs7129536 chr11:62030829 C/T cg06239285 chr11:62104954 ASRGL1 -0.82 -7.8 -0.4 8.24e-14 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs9462027 0.628 rs9462010 chr6:34716605 C/G cg07306190 chr6:34760872 UHRF1BP1 -0.35 -6.25 -0.33 1.28e-9 Systemic lupus erythematosus; CRC cis rs1707322 1.000 rs785470 chr1:46519622 C/A cg03146154 chr1:46216737 IPP -0.51 -7.09 -0.36 8.16e-12 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs9787249 0.957 rs6670841 chr1:40220284 C/G cg02773041 chr1:40204384 PPIE 0.62 9.29 0.46 2.13e-18 Blood protein levels; CRC cis rs887829 0.641 rs10197460 chr2:234589190 G/T cg07512295 chr2:234599026 UGT1A6;UGT1A10;UGT1A9;UGT1A7;UGT1A8 0.38 5.79 0.3 1.6e-8 Metabolic traits;Bilirubin levels;Cholelithiasis-related traits in sickle cell anemia;Metabolite levels;Total bilirubin levels in HIV-1 infection;Serum metabolite levels;Blood metabolite levels; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg26839812 chr6:16129282 MYLIP 0.43 6.14 0.32 2.31e-9 Intelligence (multi-trait analysis); CRC cis rs1005277 0.540 rs2474598 chr10:38430296 C/T cg26499232 chr10:38644675 HSD17B7P2 0.37 5.61 0.3 4.28e-8 Extrinsic epigenetic age acceleration; CRC cis rs1707322 1.000 rs10890381 chr1:46451771 T/G cg03146154 chr1:46216737 IPP 0.58 7.99 0.4 2.26e-14 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs1881797 1.000 rs68059491 chr1:247683070 C/T cg21399703 chr1:247681439 NA 0.5 7.94 0.4 3.29e-14 Acute lymphoblastic leukemia (childhood); CRC cis rs62244186 0.566 rs3762636 chr3:44854563 A/G cg11003573 chr3:44754125 ZNF502 -0.33 -5.85 -0.31 1.16e-8 Depressive symptoms; CRC cis rs8180040 0.627 rs58956475 chr3:47224615 G/C cg10298567 chr3:47292165 KIF9 0.4 6.28 0.33 1.08e-9 Colorectal cancer; CRC cis rs9486719 1.000 rs13210597 chr6:96969694 C/A cg18709589 chr6:96969512 KIAA0776 -0.52 -5.87 -0.31 1.06e-8 Migraine;Coronary artery disease; CRC trans rs12478296 0.892 rs11897561 chr2:243014976 C/A cg18288967 chr1:45987694 PRDX1 0.64 7.26 0.37 2.77e-12 Obesity-related traits; CRC cis rs911119 1.000 rs71334202 chr20:23618652 A/C cg16589663 chr20:23618590 CST3 0.63 8.39 0.42 1.45e-15 Chronic kidney disease; CRC cis rs2120019 0.938 rs8036573 chr15:75308690 C/T cg17294928 chr15:75287854 SCAMP5 -0.8 -11.54 -0.54 4.27e-26 Blood trace element (Zn levels); CRC cis rs11168351 1.000 rs11168351 chr12:48403765 C/T cg24011408 chr12:48396354 COL2A1 0.45 6.52 0.34 2.58e-10 Bipolar disorder and schizophrenia; CRC cis rs11785400 1.000 rs7459630 chr8:143738585 A/C cg24634471 chr8:143751801 JRK 0.53 7.52 0.38 5.14e-13 Schizophrenia; CRC cis rs4917300 0.605 rs7820768 chr8:143110823 C/T cg25363559 chr8:143086065 NA -0.32 -6.03 -0.32 4.44e-9 Amyotrophic lateral sclerosis; CRC cis rs4930561 0.714 rs10896300 chr11:67953772 C/T cg04465784 chr11:67976953 SUV420H1 0.29 5.91 0.31 8.63e-9 Breast cancer in childhood cancer survivors;IgG glycosylation; CRC cis rs1881797 0.932 rs41305741 chr1:247689543 A/G cg18198730 chr1:247681584 NA 0.55 8.61 0.43 3e-16 Acute lymphoblastic leukemia (childhood); CRC cis rs7927771 0.690 rs35496532 chr11:47450338 C/T cg05585544 chr11:47624801 NA -0.53 -9.47 -0.46 5.46e-19 Subjective well-being; CRC cis rs873946 0.586 rs3793686 chr10:134569559 A/G cg06453172 chr10:134556979 INPP5A -0.66 -8.37 -0.42 1.63e-15 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CRC cis rs2032447 0.966 rs3752416 chr6:26045929 T/C cg27635394 chr6:26043820 HIST1H2BB 0.41 6.2 0.32 1.74e-9 Intelligence (multi-trait analysis); CRC trans rs2303319 0.504 rs62189042 chr2:162602320 G/T cg03774468 chr3:140950104 ACPL2 -0.65 -6.07 -0.32 3.61e-9 Cognitive function; CRC cis rs9443645 0.901 rs4706077 chr6:79548845 G/A cg05283184 chr6:79620031 NA -0.56 -9.0 -0.44 1.85e-17 Intelligence (multi-trait analysis); CRC cis rs1218582 0.772 rs11264290 chr1:154912300 C/T cg16680214 chr1:154839983 KCNN3 -0.45 -8.77 -0.44 9.87e-17 Prostate cancer; CRC cis rs2882667 0.690 rs1651032 chr5:138078840 C/T cg09476006 chr5:138032270 NA -0.56 -9.98 -0.48 1.12e-20 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs875971 0.862 rs17747530 chr7:65994729 G/C cg18252515 chr7:66147081 NA -0.43 -6.21 -0.32 1.61e-9 Aortic root size; CRC cis rs1267303 0.675 rs2476164 chr1:46985274 T/C cg25110126 chr1:46999211 NA -0.54 -8.5 -0.42 6.78e-16 Monobrow; CRC cis rs35883536 1.000 rs17403905 chr1:101107358 T/C cg14515779 chr1:101123966 NA -0.43 -8.3 -0.42 2.75e-15 Monocyte count; CRC cis rs651907 0.557 rs3094297 chr3:101399260 A/G cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.67 9.55 0.47 3.1e-19 Colorectal cancer; CRC cis rs477895 0.938 rs28395875 chr11:64024048 G/C cg04317338 chr11:64019027 PLCB3 0.6 6.39 0.33 5.64e-10 Mean platelet volume; CRC cis rs10504229 0.683 rs35840293 chr8:58117634 C/T cg21724239 chr8:58056113 NA 0.49 6.81 0.35 4.75e-11 Developmental language disorder (linguistic errors); CRC cis rs4862750 0.872 rs1991254 chr4:187875375 T/G cg03452623 chr4:187889614 NA -0.91 -20.27 -0.75 7.51e-60 Lobe attachment (rater-scored or self-reported); CRC cis rs6460942 0.915 rs10267801 chr7:12451931 G/A cg20607287 chr7:12443886 VWDE -0.59 -6.81 -0.35 4.78e-11 Coronary artery disease; CRC cis rs1218582 0.710 rs9793588 chr1:154878878 C/G cg24250549 chr1:154909240 PMVK 0.67 11.55 0.54 4.04e-26 Prostate cancer; CRC cis rs9768139 0.524 rs7779175 chr7:158136918 C/T cg25566285 chr7:158114605 PTPRN2 -0.5 -7.82 -0.4 7.04e-14 Calcium levels; CRC cis rs1555322 0.530 rs2425043 chr20:33868702 T/C cg13662093 chr20:33865505 NA 0.42 5.9 0.31 9.18e-9 Attention deficit hyperactivity disorder; CRC cis rs7727544 0.606 rs200838 chr5:131710399 A/C cg02033258 chr5:131593261 PDLIM4 -0.3 -5.63 -0.3 3.95e-8 Blood metabolite levels; CRC cis rs801193 0.844 rs732465 chr7:65998450 T/C cg11764359 chr7:65958608 NA 0.49 7.61 0.39 2.94e-13 Aortic root size; CRC cis rs7586879 0.598 rs6545806 chr2:25124348 G/A cg22495460 chr2:25135724 ADCY3 -0.87 -17.19 -0.69 1.03e-47 Body mass index; CRC cis rs3126085 0.935 rs6587647 chr1:152192631 C/T cg09127314 chr1:152161683 NA 0.5 6.38 0.33 5.92e-10 Atopic dermatitis; CRC trans rs10242455 1.000 rs7808022 chr7:99220083 A/C cg09045935 chr12:6379348 NA 0.61 6.76 0.35 6.46e-11 Blood metabolite levels; CRC trans rs2303319 0.504 rs1023835 chr2:162593973 A/G cg22677401 chr17:46026860 NA -0.67 -6.07 -0.32 3.57e-9 Cognitive function; CRC cis rs6546537 0.824 rs13011186 chr2:69778558 C/T cg10773587 chr2:69614142 GFPT1 -0.49 -6.47 -0.34 3.45e-10 Serum thyroid-stimulating hormone levels; CRC cis rs3796352 0.892 rs2581807 chr3:53088844 G/A cg06204229 chr3:52865917 ITIH4 -0.47 -5.87 -0.31 1.05e-8 Immune reponse to smallpox (secreted IL-2); CRC cis rs4662945 0.603 rs2406981 chr2:130305487 A/G cg05903289 chr2:130345205 NA -0.4 -7.72 -0.39 1.39e-13 Response to cytidine analogues (gemcitabine); CRC cis rs4478858 0.735 rs4949393 chr1:31851875 G/A cg00250761 chr1:31883323 NA -0.43 -8.25 -0.41 3.84e-15 Alcohol dependence; CRC cis rs2075371 0.932 rs34664116 chr7:133984878 G/A cg02659138 chr7:134003124 SLC35B4 0.38 6.45 0.34 3.96e-10 Mean platelet volume; CRC cis rs1150668 0.830 rs2859365 chr6:28391465 C/T cg15845792 chr6:28175446 NA -0.46 -6.74 -0.35 7.17e-11 Pubertal anthropometrics; CRC cis rs9388451 0.807 rs1268070 chr6:126041164 A/G cg05901451 chr6:126070800 HEY2 -0.61 -10.04 -0.48 7.33e-21 Brugada syndrome; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg19034403 chr5:162993262 NA 0.45 6.33 0.33 8.09e-10 Response to antipsychotic treatment; CRC cis rs896854 0.684 rs2340534 chr8:95992330 G/A cg23172400 chr8:95962367 TP53INP1 -0.46 -7.86 -0.4 5.68e-14 Type 2 diabetes; CRC cis rs59104589 0.517 rs62186360 chr2:242166212 C/T cg19488206 chr2:242435732 STK25 0.41 6.06 0.32 3.64e-9 Fibrinogen levels; CRC cis rs8067545 0.586 rs2526478 chr17:20130452 A/G cg13482628 chr17:19912719 NA 0.45 7.02 0.36 1.26e-11 Schizophrenia; CRC cis rs7312933 0.592 rs1551210 chr12:42865874 C/T cg11827402 chr12:42719852 PPHLN1;ZCRB1 0.62 8.69 0.43 1.71e-16 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CRC trans rs542925 0.737 rs572745 chr6:128988809 G/T cg23578404 chr11:64198292 NA -0.33 -6.01 -0.31 5.06e-9 Caudate activity during reward; CRC cis rs2806561 0.514 rs10917360 chr1:23539010 C/T cg19743168 chr1:23544995 NA 0.64 9.6 0.47 2.12e-19 Height; CRC cis rs1552244 1.000 rs9809061 chr3:10085130 C/G cg13047869 chr3:10149882 C3orf24 0.53 7.44 0.38 8.73e-13 Alzheimer's disease; CRC cis rs2276314 0.857 rs16967327 chr18:33587036 C/T cg19628046 chr18:33552617 C18orf21 0.48 6.64 0.34 1.26e-10 Endometriosis;Drug-induced torsades de pointes; CRC cis rs916888 0.773 rs538628 chr17:44787313 G/C cg17911788 chr17:44343683 NA -0.65 -7.35 -0.38 1.59e-12 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs13064411 0.696 rs6798938 chr3:113218206 C/T cg18753928 chr3:113234510 CCDC52 -0.71 -10.96 -0.52 5.03e-24 Response to simvastatin treatment (PCSK9 protein level change); CRC trans rs2228479 0.702 rs2074903 chr16:89811663 T/C cg21302420 chr1:112162376 RAP1A 0.72 6.01 0.31 5.05e-9 Skin colour saturation; CRC cis rs4665809 1.000 rs750450 chr2:26324631 A/G cg27170947 chr2:26402098 FAM59B -0.44 -5.68 -0.3 3.04e-8 Gut microbiome composition (summer); CRC cis rs317689 0.819 rs317685 chr12:69715457 A/G cg20891283 chr12:69753455 YEATS4 -0.47 -6.14 -0.32 2.33e-9 Response to diuretic therapy; CRC cis rs9341808 0.667 rs1408292 chr6:80883906 G/T cg08355045 chr6:80787529 NA 0.39 6.59 0.34 1.7e-10 Sitting height ratio; CRC cis rs10504229 0.775 rs55764517 chr8:58158238 G/A cg24829409 chr8:58192753 C8orf71 -0.6 -8.07 -0.41 1.29e-14 Developmental language disorder (linguistic errors); CRC cis rs6964587 0.869 rs11769726 chr7:91485231 A/G cg17063962 chr7:91808500 NA -0.7 -11.61 -0.54 2.42e-26 Breast cancer; CRC cis rs11971779 0.941 rs74299967 chr7:139043769 G/T cg07862535 chr7:139043722 LUC7L2 1.05 12.72 0.57 2e-30 Diisocyanate-induced asthma; CRC cis rs2857891 0.695 rs2857893 chr11:6983330 C/T cg04053776 chr11:6947353 ZNF215 0.39 6.01 0.31 4.84e-9 Response to cytadine analogues (cytosine arabinoside); CRC cis rs9467711 0.651 rs13220395 chr6:26055368 A/G cg08501292 chr6:25962987 TRIM38 -1.02 -9.24 -0.45 3.16e-18 Autism spectrum disorder or schizophrenia; CRC cis rs11077815 0.733 rs4516263 chr17:74432562 A/G cg06840243 chr17:74442338 UBE2O 0.42 6.84 0.35 3.96e-11 Lymphocyte counts; CRC cis rs12142240 0.667 rs45524035 chr1:46862780 C/T cg00530320 chr1:46809349 NSUN4 0.59 8.01 0.4 1.95e-14 Menopause (age at onset); CRC trans rs66887589 0.870 rs2389875 chr4:120557014 G/T cg25214090 chr10:38739885 LOC399744 -0.39 -6.07 -0.32 3.51e-9 Diastolic blood pressure; CRC cis rs56235845 0.694 rs36102285 chr5:176774018 C/T cg17261708 chr5:176794207 RGS14 0.49 8.08 0.41 1.23e-14 Hemoglobin concentration;Hematocrit; CRC cis rs1005277 0.505 rs200936 chr10:38134935 T/C cg00409905 chr10:38381863 ZNF37A -0.63 -10.46 -0.5 2.79e-22 Extrinsic epigenetic age acceleration; CRC trans rs16846053 0.579 rs57887363 chr2:162588720 C/T cg10498984 chr16:28874827 SH2B1 -0.73 -6.11 -0.32 2.82e-9 Blood osmolality (transformed sodium); CRC cis rs372883 0.624 rs1153286 chr21:30684383 A/G cg24692254 chr21:30365293 RNF160 -0.55 -8.47 -0.42 8.01e-16 Pancreatic cancer; CRC cis rs4563143 0.663 rs10406794 chr19:29228056 C/T cg03161606 chr19:29218774 NA 0.63 8.42 0.42 1.21e-15 Methadone dose in opioid dependence; CRC cis rs8105895 0.935 rs10404669 chr19:22241218 T/C cg02657401 chr19:22469223 NA -0.34 -5.65 -0.3 3.56e-8 Body mass index (change over time); CRC cis rs12451471 0.637 rs7567 chr17:78093549 G/T cg24585782 chr17:78113791 EIF4A3 -0.52 -7.13 -0.37 6.51e-12 Plateletcrit;Mean corpuscular hemoglobin concentration; CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg07355693 chr12:125667907 NA 0.38 5.97 0.31 6.23e-9 Obesity-related traits; CRC trans rs57590327 0.503 rs9852235 chr3:81508355 A/G cg23387109 chr10:94051229 MARCH5;CPEB3 -0.44 -5.98 -0.31 5.85e-9 Extraversion; CRC cis rs6951245 0.554 rs35126802 chr7:1134842 C/T cg18297960 chr7:1142765 C7orf50 -0.45 -6.18 -0.32 1.93e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs800160 0.720 rs11022259 chr11:2338256 A/G cg09785033 chr11:2336066 TSPAN32 -0.49 -5.64 -0.3 3.66e-8 Bacteremia; CRC cis rs6089584 0.526 rs6089316 chr20:60627552 C/T cg06108461 chr20:60628389 TAF4 -0.74 -11.99 -0.55 1.01e-27 Body mass index; CRC cis rs4594175 0.926 rs11851960 chr14:51598610 A/G cg23942311 chr14:51606299 NA 0.67 11.22 0.53 5.87e-25 Cancer; CRC cis rs798554 0.959 rs798528 chr7:2772431 A/C cg17321639 chr7:2759063 NA -0.52 -6.9 -0.36 2.74e-11 Height; CRC cis rs2239547 0.618 rs4687658 chr3:52860366 C/G cg11645453 chr3:52864694 ITIH4 0.62 11.22 0.53 5.75e-25 Schizophrenia; CRC cis rs4713118 0.513 rs9368547 chr6:28028067 A/G cg03623178 chr6:28175578 NA 0.79 11.55 0.54 3.91e-26 Parkinson's disease; CRC cis rs7249142 0.549 rs741706 chr19:19281672 C/T cg08207377 chr19:19281140 LOC729991-MEF2B;MEF2B -0.38 -6.2 -0.32 1.69e-9 IgG glycosylation; CRC cis rs834811 0.602 rs12533021 chr7:135889342 C/T cg01726295 chr7:135938950 NA 0.35 6.07 0.32 3.49e-9 Post-traumatic stress disorder; CRC trans rs9858542 1.000 rs2172252 chr3:49678307 A/T cg21665057 chr3:196295764 WDR53;FBXO45 -0.66 -8.58 -0.43 3.8e-16 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs6570726 0.905 rs419575 chr6:145840174 A/G cg05347473 chr6:146136440 FBXO30 0.37 6.0 0.31 5.27e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs2692947 0.770 rs11689832 chr2:96554851 A/C cg23100626 chr2:96804247 ASTL 0.27 7.07 0.36 9.57e-12 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; CRC cis rs7408868 1.000 rs10407320 chr19:15275716 G/C cg14696996 chr19:15285081 NOTCH3 0.97 8.99 0.44 1.99e-17 Pulse pressure; CRC cis rs9399135 0.935 rs2150680 chr6:135347131 G/C cg24558204 chr6:135376177 HBS1L 0.52 8.23 0.41 4.52e-15 Red blood cell count; CRC cis rs17818399 0.735 rs11894342 chr2:46836439 A/T cg26688816 chr2:46740690 ATP6V1E2 -0.44 -6.7 -0.35 9.1e-11 Height; CRC cis rs9318086 0.673 rs7981928 chr13:24435180 T/G cg25267304 chr13:24462978 PCOTH;MIPEP 0.63 10.15 0.49 2.97e-21 Myopia (pathological); CRC cis rs6597981 0.675 rs4963120 chr11:825777 A/G cg01741372 chr11:783889 NA -0.43 -6.42 -0.33 4.63e-10 Breast cancer; CRC cis rs7552404 0.696 rs10782602 chr1:76464261 T/C cg10523679 chr1:76189770 ACADM 0.72 8.41 0.42 1.26e-15 Blood metabolite levels;Acylcarnitine levels; CRC trans rs2727020 0.595 rs10769583 chr11:49483193 G/A cg15704280 chr7:45808275 SEPT13 -0.95 -18.16 -0.71 1.58e-51 Coronary artery disease; CRC cis rs798554 0.704 rs798513 chr7:2782493 C/T cg04166393 chr7:2884313 GNA12 0.39 6.05 0.32 4.04e-9 Height; CRC cis rs4713118 0.587 rs9393899 chr6:28133528 G/C cg12172441 chr6:28176163 NA 0.64 7.53 0.38 5.03e-13 Parkinson's disease; CRC cis rs7618915 0.501 rs1866268 chr3:52719398 C/A cg18404041 chr3:52824283 ITIH1 -0.4 -8.43 -0.42 1.09e-15 Bipolar disorder; CRC cis rs853679 0.517 rs4713143 chr6:28106759 A/C cg21251018 chr6:28226885 NKAPL 0.48 6.33 0.33 7.86e-10 Depression; CRC cis rs10504229 0.683 rs72649188 chr8:58108829 A/G cg05313129 chr8:58192883 C8orf71 -0.43 -5.83 -0.31 1.36e-8 Developmental language disorder (linguistic errors); CRC cis rs10504229 1.000 rs7007805 chr8:58179327 G/A cg01721255 chr8:58191610 C8orf71 0.49 6.17 0.32 2e-9 Developmental language disorder (linguistic errors); CRC cis rs72799341 1.000 rs35675346 chr16:30936081 G/A cg00531865 chr16:30841666 NA -0.48 -6.02 -0.32 4.54e-9 Diastolic blood pressure; CRC cis rs9487051 0.676 rs9374077 chr6:109600194 C/T cg21918786 chr6:109611834 NA -0.4 -7.13 -0.37 6.28e-12 Reticulocyte fraction of red cells; CRC cis rs9525927 0.570 rs9316074 chr13:44803181 A/G cg19190762 chr13:44806055 NA 0.57 6.93 0.36 2.2e-11 Dupuytren's disease; CRC cis rs6761276 0.649 rs3811055 chr2:113831182 A/T cg12858261 chr2:113808755 IL1F8 0.46 6.68 0.35 1.02e-10 Protein quantitative trait loci; CRC cis rs3126085 0.825 rs11204938 chr1:152193990 A/G cg09127314 chr1:152161683 NA 0.52 6.81 0.35 4.79e-11 Atopic dermatitis; CRC cis rs12368653 0.591 rs1552842 chr12:58012163 A/G cg00700412 chr12:58011837 NA -0.43 -6.76 -0.35 6.4e-11 Multiple sclerosis; CRC cis rs4713118 0.955 rs9468203 chr6:27688667 A/G cg15786705 chr6:28176104 NA 0.47 6.12 0.32 2.71e-9 Parkinson's disease; CRC cis rs9457247 0.765 rs10455982 chr6:167448728 C/T cg07741184 chr6:167504864 NA 0.39 6.63 0.34 1.4e-10 Crohn's disease; CRC trans rs11165623 0.564 rs6673207 chr1:96999259 C/G cg10631902 chr5:14652156 NA -0.37 -6.41 -0.33 5.08e-10 Hip circumference;Waist circumference; CRC cis rs17826219 0.561 rs11655876 chr17:29017150 G/A cg13385521 chr17:29058706 SUZ12P 0.59 7.23 0.37 3.44e-12 Body mass index; CRC cis rs4285028 0.747 rs7623901 chr3:121529011 A/G cg11130432 chr3:121712080 ILDR1 0.48 5.75 0.3 2.01e-8 Multiple sclerosis; CRC cis rs9322193 0.962 rs9689242 chr6:150109106 T/C cg00933542 chr6:150070202 PCMT1 0.28 5.63 0.3 3.86e-8 Lung cancer; CRC cis rs6496667 0.865 rs12593879 chr15:90924508 A/T cg04176472 chr15:90893244 GABARAPL3 0.6 7.86 0.4 5.41e-14 Rheumatoid arthritis; CRC cis rs4523957 0.928 rs4790321 chr17:2173499 C/T cg16513277 chr17:2031491 SMG6 -0.55 -9.44 -0.46 6.96e-19 Autism spectrum disorder or schizophrenia;Schizophrenia; CRC cis rs73206853 0.640 rs35026231 chr12:110832125 A/G cg12870014 chr12:110450643 ANKRD13A 0.85 10.18 0.49 2.4e-21 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC cis rs1215050 0.791 rs2658477 chr4:98850993 G/A cg05340658 chr4:99064831 C4orf37 -0.48 -7.16 -0.37 5.35e-12 Waist-to-hip ratio adjusted for body mass index; CRC cis rs2408955 0.522 rs973398 chr12:48491048 A/G cg00601486 chr12:48723148 H1FNT -0.34 -6.67 -0.35 1.09e-10 Glycated hemoglobin levels; CRC cis rs8062405 1.000 rs62036620 chr16:28833097 A/G cg08761264 chr16:28874980 SH2B1 -0.42 -5.66 -0.3 3.26e-8 Cognitive ability (multi-trait analysis);Cognitive ability; CRC cis rs11148252 0.595 rs4884522 chr13:53053768 C/A cg12458913 chr13:53173898 NA 0.76 13.91 0.61 6.24e-35 Lewy body disease; CRC cis rs10208940 0.764 rs6546418 chr2:68786563 G/A cg12452813 chr2:68675892 NA 0.46 5.75 0.3 2.05e-8 Urate levels in lean individuals; CRC cis rs4713118 0.955 rs34752872 chr6:27683244 A/T cg25164649 chr6:28176230 NA 0.56 7.44 0.38 9.1e-13 Parkinson's disease; CRC cis rs7258465 1.000 rs10405636 chr19:18538742 A/C cg01065977 chr19:18549689 ISYNA1 -0.41 -6.27 -0.33 1.15e-9 Breast cancer; CRC cis rs13108904 0.967 rs4405964 chr4:1278814 A/G cg16405210 chr4:1374714 KIAA1530 -0.46 -6.34 -0.33 7.54e-10 Obesity-related traits; CRC cis rs951366 0.617 rs823074 chr1:205774839 T/C cg17178900 chr1:205818956 PM20D1 0.84 13.62 0.6 8.16e-34 Menarche (age at onset); CRC cis rs7811142 0.943 rs67196635 chr7:100025564 T/C cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.16 17.98 0.7 7.57e-51 Platelet count; CRC cis rs1059312 0.808 rs4482069 chr12:129294252 G/C cg23521905 chr12:129298690 SLC15A4;MGC16384 0.38 6.5 0.34 3.04e-10 Systemic lupus erythematosus; CRC trans rs8073060 0.586 rs188959 chr17:34021307 C/A cg19694781 chr19:47549865 TMEM160 -1.06 -14.24 -0.62 3.54e-36 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; CRC cis rs62432291 0.681 rs447637 chr6:159658726 A/G cg14500486 chr6:159655392 FNDC1 -0.77 -10.43 -0.5 3.48e-22 Joint mobility (Beighton score); CRC cis rs10504229 0.728 rs17804750 chr8:58155751 T/C cg22535103 chr8:58192502 C8orf71 -0.68 -8.37 -0.42 1.72e-15 Developmental language disorder (linguistic errors); CRC cis rs72799341 0.706 rs59735493 chr16:31133100 G/A cg02466173 chr16:30829666 NA -0.42 -5.67 -0.3 3.17e-8 Diastolic blood pressure; CRC cis rs9467711 0.606 rs34273322 chr6:26415409 T/A cg16898833 chr6:26189333 HIST1H4D 0.89 7.28 0.37 2.4e-12 Autism spectrum disorder or schizophrenia; CRC cis rs270601 0.770 rs10463891 chr5:131597392 C/T cg09877947 chr5:131593287 PDLIM4 -0.56 -10.5 -0.5 1.99e-22 Acylcarnitine levels; CRC cis rs6570726 0.935 rs371744 chr6:145841024 C/T cg23711669 chr6:146136114 FBXO30 0.68 12.0 0.55 9.22e-28 Lobe attachment (rater-scored or self-reported); CRC cis rs9911578 0.904 rs7209253 chr17:56908987 C/T cg05425664 chr17:57184151 TRIM37 -0.49 -7.72 -0.39 1.45e-13 Intelligence (multi-trait analysis); CRC cis rs13256369 1.000 rs10110591 chr8:8576608 G/T cg17143192 chr8:8559678 CLDN23 -0.54 -7.5 -0.38 5.9e-13 Obesity-related traits; CRC cis rs796364 1.000 rs281763 chr2:200794870 C/T cg23649088 chr2:200775458 C2orf69 0.55 6.01 0.31 4.94e-9 Schizophrenia; CRC cis rs17601876 0.623 rs1062033 chr15:51547938 C/G cg19946085 chr15:51559439 CYP19A1 -0.33 -6.58 -0.34 1.85e-10 Estrone/androstenedione ratio in resected early stage-receptor positive breast cancer; CRC trans rs951252 0.504 rs11734405 chr4:146081096 C/T cg26569395 chr2:68694513 APLF;FBXO48 0.51 6.63 0.34 1.34e-10 Hip circumference; CRC cis rs447 0.767 rs6977306 chr7:83750053 G/A cg22846510 chr7:83753280 SEMA3A -0.42 -5.83 -0.31 1.33e-8 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs7781266 0.790 rs4731951 chr7:133102282 G/T cg03336402 chr7:133662267 EXOC4 -0.48 -5.72 -0.3 2.4e-8 Educational attainment (college completion); CRC cis rs10504229 0.679 rs7839948 chr8:58130607 A/G cg24829409 chr8:58192753 C8orf71 -0.55 -8.03 -0.4 1.71e-14 Developmental language disorder (linguistic errors); CRC cis rs853679 0.517 rs9295759 chr6:28124469 C/T cg03623178 chr6:28175578 NA 0.98 12.66 0.57 3.31e-30 Depression; CRC cis rs6502050 0.835 rs10163482 chr17:80110394 C/A cg13198984 chr17:80129470 CCDC57 0.46 8.16 0.41 6.94e-15 Life satisfaction; CRC cis rs7680126 0.633 rs74469609 chr4:10294424 G/A cg00071950 chr4:10020882 SLC2A9 -0.46 -6.02 -0.31 4.73e-9 Urate levels in lean individuals;Urate levels in overweight individuals;Urate levels in obese individuals; CRC cis rs847649 1.000 rs9718453 chr7:102594976 T/G cg18108683 chr7:102477205 FBXL13 0.58 9.37 0.46 1.17e-18 Morning vs. evening chronotype; CRC cis rs12644284 0.516 rs6535908 chr4:154138086 A/G cg05870820 chr4:154142712 TRIM2 0.42 5.85 0.31 1.18e-8 Multiple sclerosis; CRC cis rs6831352 0.879 rs2602888 chr4:100041706 C/T cg12011299 chr4:100065546 ADH4 0.5 9.46 0.46 5.98e-19 Alcohol dependence; CRC cis rs60154123 0.505 rs1319435 chr1:210047618 C/T cg22029157 chr1:209979665 IRF6 -0.61 -6.7 -0.35 8.84e-11 Coronary artery disease; CRC cis rs17376456 0.877 rs12716457 chr5:93397627 T/C cg25358565 chr5:93447407 FAM172A 1.02 10.4 0.5 4.25e-22 Diabetic retinopathy; CRC cis rs6582630 0.555 rs10880421 chr12:38423015 C/T cg13010199 chr12:38710504 ALG10B 0.45 5.72 0.3 2.37e-8 Drug-induced liver injury (flucloxacillin); CRC trans rs10916814 0.632 rs10799646 chr1:20903985 G/T cg24589459 chr2:198651347 BOLL -0.32 -6.15 -0.32 2.25e-9 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs720844 0.507 rs13003024 chr2:149285093 A/G cg09247360 chr2:149335327 NA 0.42 5.67 0.3 3.06e-8 Peripheral arterial disease (traffic-related air pollution interaction); CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg20322375 chr12:83080681 TMTC2 0.44 6.13 0.32 2.52e-9 Anxiety disorder; CRC cis rs2742540 0.503 rs7106539 chr11:8897533 T/G cg14711859 chr11:8959438 ASCL3 0.53 9.76 0.47 6.11e-20 Hematocrit; CRC cis rs6952808 0.760 rs34961072 chr7:1948620 G/C cg22963979 chr7:1858916 MAD1L1 -0.55 -7.88 -0.4 4.82e-14 Bipolar disorder and schizophrenia; CRC cis rs798554 0.723 rs798518 chr7:2777825 A/G cg19717773 chr7:2847554 GNA12 -0.41 -6.13 -0.32 2.48e-9 Height; CRC cis rs2840044 1.000 rs11653310 chr17:33893378 C/G cg05299278 chr17:33885742 SLFN14 0.4 6.08 0.32 3.4e-9 Response to radiotherapy in cancer (late toxicity); CRC cis rs9814567 0.929 rs1863912 chr3:134205227 C/T cg06541857 chr3:134203789 ANAPC13;CEP63 -0.42 -6.43 -0.33 4.42e-10 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs2692947 0.770 rs2579552 chr2:96737083 A/G cg23100626 chr2:96804247 ASTL 0.28 7.51 0.38 5.63e-13 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; CRC trans rs7824557 0.872 rs1347410 chr8:11111242 G/A cg16141378 chr3:129829833 LOC729375 0.46 6.67 0.35 1.09e-10 Retinal vascular caliber; CRC cis rs10504229 1.000 rs73607875 chr8:58173522 T/C cg05313129 chr8:58192883 C8orf71 -0.47 -6.99 -0.36 1.49e-11 Developmental language disorder (linguistic errors); CRC cis rs4713118 0.513 rs156739 chr6:28013410 C/A cg20615401 chr6:28092323 ZSCAN16 0.47 6.24 0.33 1.31e-9 Parkinson's disease; CRC cis rs798554 0.679 rs1636253 chr7:2885123 A/G cg13628971 chr7:2884303 GNA12 0.6 8.31 0.42 2.51e-15 Height; CRC cis rs6860806 0.507 rs273912 chr5:131661349 A/C cg09877947 chr5:131593287 PDLIM4 -0.44 -7.27 -0.37 2.65e-12 Breast cancer; CRC cis rs4728302 0.608 rs6967856 chr7:133727304 C/T cg03336402 chr7:133662267 EXOC4 -0.43 -6.59 -0.34 1.72e-10 Intelligence;Intelligence (multi-trait analysis); CRC cis rs10504229 0.683 rs72650847 chr8:58136825 C/T cg22535103 chr8:58192502 C8orf71 -0.78 -8.69 -0.43 1.78e-16 Developmental language disorder (linguistic errors); CRC cis rs6714710 0.603 rs11679828 chr2:98517626 G/A cg26665480 chr2:98280029 ACTR1B 0.54 7.49 0.38 6.23e-13 Posterior cortical atrophy and Alzheimer's disease; CRC cis rs2228479 0.702 rs11076620 chr16:89831520 A/T cg06656553 chr16:89960601 TCF25 -0.7 -5.84 -0.31 1.23e-8 Skin colour saturation; CRC cis rs853679 0.550 rs1237875 chr6:28173010 A/G cg21251018 chr6:28226885 NKAPL -0.48 -6.88 -0.35 3.03e-11 Depression; CRC cis rs7618501 0.602 rs2526754 chr3:50125996 G/A cg05623727 chr3:50126028 RBM5 -0.44 -7.47 -0.38 7.28e-13 Intelligence (multi-trait analysis); CRC trans rs12940923 0.748 rs56298529 chr17:56363859 T/A cg16900910 chr15:72789182 ARIH1 0.52 5.97 0.31 6.14e-9 Circulating myeloperoxidase levels (plasma); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg23970856 chr2:55459633 RPS27A;C2orf63 0.43 6.51 0.34 2.79e-10 Liver disease severity in Alagille syndrome; CRC cis rs10788264 0.544 rs9630083 chr10:124017423 C/T cg05683857 chr10:124030795 BTBD16 0.34 6.09 0.32 3.12e-9 Total body bone mineral density; CRC cis rs1451375 1.000 rs1451374 chr7:50622653 G/A cg18232548 chr7:50535776 DDC 0.47 6.68 0.35 9.94e-11 Malaria; CRC cis rs311392 0.902 rs2666874 chr8:55091561 A/T cg20636351 chr8:55087400 NA 0.33 5.89 0.31 9.54e-9 Pelvic organ prolapse (moderate/severe); CRC trans rs2303319 0.504 rs62189043 chr2:162608466 A/T cg22922770 chr7:98923339 ARPC1A -0.67 -5.98 -0.31 5.68e-9 Cognitive function; CRC cis rs76878669 0.561 rs10791872 chr11:66138434 C/G cg18002602 chr11:66138449 SLC29A2 -0.32 -6.75 -0.35 6.88e-11 Educational attainment (years of education); CRC cis rs7044106 0.791 rs4617229 chr9:123480696 A/G cg09586646 chr9:123605570 PSMD5;LOC253039 0.61 9.12 0.45 7.62e-18 Hip circumference adjusted for BMI; CRC cis rs6696846 0.749 rs61822566 chr1:205078660 T/C cg00857998 chr1:205179979 DSTYK 0.41 5.76 0.3 1.96e-8 Red blood cell count; CRC cis rs9916302 0.861 rs644173 chr17:37430519 T/C cg07936489 chr17:37558343 FBXL20 -0.79 -11.78 -0.54 5.73e-27 Glomerular filtration rate (creatinine); CRC cis rs13191362 0.935 rs13193473 chr6:162966852 C/A cg21926612 chr6:163149169 PACRG;PARK2 0.85 10.65 0.51 5.97e-23 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs11764590 0.671 rs62444906 chr7:2083161 G/T cg24505167 chr7:1915268 MAD1L1 -0.44 -6.14 -0.32 2.33e-9 Neuroticism; CRC cis rs6429082 0.509 rs7516807 chr1:235523555 G/T cg26050004 chr1:235667680 B3GALNT2 0.41 5.95 0.31 6.88e-9 Adiposity; CRC cis rs10504229 0.953 rs115634610 chr8:58190533 G/A cg22535103 chr8:58192502 C8orf71 -0.81 -12.2 -0.56 1.72e-28 Developmental language disorder (linguistic errors); CRC trans rs11039798 0.588 rs11039782 chr11:48524785 A/G cg03929089 chr4:120376271 NA 0.64 6.6 0.34 1.62e-10 Axial length; CRC cis rs7224685 0.859 rs34348519 chr17:4094140 G/C cg09695851 chr17:3907499 NA 0.43 5.98 0.31 5.68e-9 Type 2 diabetes; CRC cis rs4927850 0.958 rs1975582 chr3:195751439 G/T cg01181863 chr3:195395398 SDHAP2 -0.57 -7.93 -0.4 3.4e-14 Pancreatic cancer; CRC cis rs72945132 0.882 rs12278741 chr11:70135742 A/G cg00319359 chr11:70116639 PPFIA1 0.67 7.4 0.38 1.16e-12 Coronary artery disease; CRC cis rs1008375 1.000 rs2109522 chr4:17658645 T/A cg16339924 chr4:17578868 LAP3 0.59 8.05 0.41 1.57e-14 Parasitemia in Tripanosoma cruzi seropositivity; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg25503565 chr17:38264529 NA 0.41 7.28 0.37 2.49e-12 Liver disease severity in Alagille syndrome; CRC cis rs11069349 0.608 rs9585056 chr13:100081766 A/G cg15490075 chr13:100150979 NA -0.43 -5.73 -0.3 2.21e-8 Self-reported allergy; CRC cis rs2880765 0.835 rs6497202 chr15:86021375 T/C cg17133734 chr15:86042851 AKAP13 0.42 6.78 0.35 5.47e-11 Coronary artery disease; CRC cis rs6502050 1.000 rs6502050 chr17:80058236 C/G cg02741985 chr17:80059408 CCDC57 -0.45 -7.38 -0.38 1.3e-12 Life satisfaction; CRC cis rs561341 0.769 rs9899093 chr17:30191954 C/G cg12193833 chr17:30244370 NA -0.56 -6.43 -0.33 4.5e-10 Hip circumference adjusted for BMI; CRC cis rs2576037 0.526 rs2156050 chr18:44455873 A/G cg19077165 chr18:44547161 KATNAL2 -0.6 -10.08 -0.49 5.31e-21 Personality dimensions; CRC cis rs1215050 0.740 rs783949 chr4:99001933 A/G cg05340658 chr4:99064831 C4orf37 -0.48 -7.26 -0.37 2.75e-12 Waist-to-hip ratio adjusted for body mass index; CRC cis rs13082711 0.554 rs9310843 chr3:27371260 A/G cg02860705 chr3:27208620 NA 0.54 7.7 0.39 1.65e-13 Systolic blood pressure;Diastolic blood pressure;Blood pressure; CRC cis rs7517126 1.000 rs6428367 chr1:196844192 C/T cg13682187 chr1:196946512 CFHR5 0.37 5.95 0.31 6.99e-9 Blood protein levels; CRC cis rs4820294 0.669 rs7287358 chr22:38054403 A/G cg21798802 chr22:38057573 PDXP 0.35 5.68 0.3 2.93e-8 Fat distribution (HIV); CRC cis rs847649 0.692 rs1541519 chr7:102466741 G/T cg18108683 chr7:102477205 FBXL13 -0.67 -11.27 -0.53 3.79e-25 Morning vs. evening chronotype; CRC cis rs35110281 0.777 rs7276215 chr21:44990697 A/G cg01579765 chr21:45077557 HSF2BP -0.37 -7.11 -0.36 7.22e-12 Mean corpuscular volume; CRC cis rs6912958 0.684 rs6931069 chr6:88367082 C/T cg08069147 chr6:88032118 GJB7;C6orf162 -0.5 -7.42 -0.38 1.02e-12 Monocyte percentage of white cells; CRC cis rs7264396 0.561 rs6142470 chr20:34570579 T/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.6 -8.22 -0.41 4.68e-15 Total cholesterol levels; CRC cis rs10504229 0.728 rs17215621 chr8:58152706 C/A cg08219700 chr8:58056026 NA 0.45 5.74 0.3 2.11e-8 Developmental language disorder (linguistic errors); CRC cis rs629535 0.814 rs477200 chr8:70059584 A/G cg26132723 chr8:70041827 NA 0.33 5.84 0.31 1.25e-8 Dupuytren's disease; CRC trans rs2727020 0.702 rs609054 chr11:49219725 C/G cg03929089 chr4:120376271 NA 0.82 13.72 0.6 3.47e-34 Coronary artery disease; CRC cis rs96067 0.711 rs795047 chr1:36637708 C/T cg25304816 chr1:36627734 MAP7D1 -0.57 -9.08 -0.45 1.02e-17 Corneal structure; CRC cis rs12692738 0.526 rs355861 chr2:165629963 A/G cg03182029 chr2:165697222 COBLL1 0.51 6.07 0.32 3.46e-9 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);Waist-to-hip ratio adjusted for BMI in non-smokers;Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction);Waist-to-hip ratio adjusted for body mass index; CRC cis rs2120019 1.000 rs1867146 chr15:75354971 C/G cg11632617 chr15:75315747 PPCDC -0.54 -7.22 -0.37 3.57e-12 Blood trace element (Zn levels); CRC cis rs727505 0.866 rs56216989 chr7:124729068 T/A cg23710748 chr7:124431027 NA -0.72 -12.33 -0.56 5.81e-29 Lewy body disease; CRC cis rs3768617 0.510 rs10797844 chr1:183082067 C/T ch.1.3577855R chr1:183094577 LAMC1 0.88 15.5 0.65 4.51e-41 Fuchs's corneal dystrophy; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg06618610 chr16:87811655 NA 0.49 6.97 0.36 1.73e-11 Response to antipsychotic treatment; CRC cis rs8060686 0.858 rs10468274 chr16:67922342 C/T cg07125278 chr16:67683757 RLTPR -0.49 -6.75 -0.35 6.86e-11 HDL cholesterol;Metabolic syndrome; CRC trans rs11764590 0.950 rs55683212 chr7:2078855 G/C cg11693508 chr17:37793320 STARD3 0.6 7.17 0.37 4.95e-12 Neuroticism; CRC cis rs910316 1.000 rs175449 chr14:75590846 A/T cg03030879 chr14:75389066 RPS6KL1 0.46 7.2 0.37 4.2e-12 Height; CRC trans rs13079221 0.614 rs182403 chr3:14903391 T/C cg18308285 chr17:7942551 ALOX15B 0.42 6.03 0.32 4.4e-9 Coronary artery disease; CRC cis rs637571 0.522 rs679581 chr11:65746653 A/G cg02427764 chr11:65769310 BANF1;EIF1AD 0.4 5.73 0.3 2.24e-8 Eosinophil percentage of white cells; CRC trans rs2727020 0.729 rs2204366 chr11:49349367 A/C cg15704280 chr7:45808275 SEPT13 0.87 15.79 0.66 3.48e-42 Coronary artery disease; CRC cis rs561341 0.505 rs548298 chr17:30297494 C/A cg00745463 chr17:30367425 LRRC37B -0.75 -9.09 -0.45 9.8e-18 Hip circumference adjusted for BMI; CRC cis rs4363385 0.510 rs6686526 chr1:153044996 T/C cg25856811 chr1:152973957 SPRR3 -0.21 -5.66 -0.3 3.22e-8 Inflammatory skin disease; CRC cis rs11123170 0.650 rs2289897 chr2:113977454 G/A cg21610815 chr2:113994035 PAX8;LOC654433;LOC440839 0.56 6.73 0.35 7.73e-11 Renal function-related traits (BUN); CRC cis rs10197940 0.648 rs7587301 chr2:152347600 A/G cg06191203 chr2:152266755 RIF1 -0.46 -6.46 -0.34 3.76e-10 Lung cancer; CRC cis rs4862750 0.881 rs6813866 chr4:187872161 T/G cg22105103 chr4:187893119 NA 0.63 11.26 0.53 4.39e-25 Lobe attachment (rater-scored or self-reported); CRC cis rs9303280 0.742 rs11557466 chr17:38024626 C/T cg11212589 chr17:38028394 ZPBP2 0.43 7.94 0.4 3.15e-14 Self-reported allergy; CRC cis rs4481887 0.504 rs10888323 chr1:248361201 C/T cg00666640 chr1:248458726 OR2T12 0.44 7.07 0.36 9.39e-12 Common traits (Other); CRC cis rs11971779 0.646 rs58682779 chr7:139084712 C/T cg07862535 chr7:139043722 LUC7L2 1.05 12.68 0.57 2.8e-30 Diisocyanate-induced asthma; CRC cis rs6502050 0.799 rs8066370 chr17:80102105 T/C cg09264619 chr17:80180166 NA -0.34 -5.81 -0.3 1.5e-8 Life satisfaction; CRC cis rs10751667 0.666 rs12295141 chr11:947065 G/A cg23136738 chr11:925521 AP2A2 -0.41 -6.99 -0.36 1.56e-11 Alzheimer's disease (late onset); CRC cis rs68170813 0.559 rs7800443 chr7:106910723 G/A cg02696742 chr7:106810147 HBP1 -0.61 -6.7 -0.35 9.26e-11 Coronary artery disease; CRC cis rs853679 0.760 rs9295768 chr6:28209102 G/A cg12273811 chr6:28175739 NA 0.55 5.86 0.31 1.12e-8 Depression; CRC cis rs55788414 0.932 rs12103301 chr16:81181423 A/C cg06400318 chr16:81190750 PKD1L2 -0.57 -6.41 -0.33 4.95e-10 Left ventricular obstructive tract defect (maternal effect); CRC cis rs13315871 0.929 rs13322156 chr3:58287620 C/T cg20936604 chr3:58311152 NA -0.74 -6.94 -0.36 2.05e-11 Cholesterol, total; CRC cis rs10504229 0.683 rs79284841 chr8:58107611 T/A cg11062466 chr8:58055876 NA 0.61 7.3 0.37 2.21e-12 Developmental language disorder (linguistic errors); CRC cis rs8077889 1.000 rs2880329 chr17:41866168 T/A cg25876840 chr17:41920477 NA 0.56 7.59 0.39 3.26e-13 Triglycerides; CRC cis rs904251 0.523 rs2776874 chr6:37483197 C/T cg25019722 chr6:37503610 NA -0.44 -8.29 -0.42 3.02e-15 Cognitive performance; CRC cis rs599083 0.530 rs686921 chr11:68170833 G/T cg01657329 chr11:68192670 LRP5 0.46 6.65 0.34 1.19e-10 Bone mineral density (spine); CRC cis rs10751667 0.666 rs7395823 chr11:942701 T/C cg06064525 chr11:970664 AP2A2 -0.31 -6.16 -0.32 2.18e-9 Alzheimer's disease (late onset); CRC cis rs10752881 1.000 rs10737237 chr1:182989269 A/G ch.1.3577855R chr1:183094577 LAMC1 0.86 15.17 0.64 8.93e-40 Colorectal cancer; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg01270033 chr16:14165057 MKL2 0.39 6.44 0.33 4.29e-10 Liver disease severity in Alagille syndrome; CRC cis rs651907 0.557 rs34181125 chr3:101490278 A/G cg11279151 chr3:101281821 RG9MTD1 -0.48 -6.47 -0.34 3.47e-10 Colorectal cancer; CRC cis rs68170813 0.641 rs4730228 chr7:106904077 T/C cg02696742 chr7:106810147 HBP1 -0.6 -6.65 -0.34 1.25e-10 Coronary artery disease; CRC cis rs7772486 0.597 rs2485631 chr6:146190077 G/C cg05347473 chr6:146136440 FBXO30 0.48 6.9 0.36 2.7e-11 Lobe attachment (rater-scored or self-reported); CRC cis rs524281 0.648 rs4565902 chr11:65810045 T/G cg16950941 chr11:66035639 RAB1B -0.52 -5.77 -0.3 1.81e-8 Electroencephalogram traits; CRC cis rs9487051 0.676 rs1608044 chr6:109594076 T/C cg21918786 chr6:109611834 NA -0.43 -7.47 -0.38 7.39e-13 Reticulocyte fraction of red cells; CRC cis rs7412746 0.621 rs72704656 chr1:150828307 A/G cg18016565 chr1:150552671 MCL1 0.42 5.8 0.3 1.52e-8 Melanoma; CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg18876494 chr12:69004196 RAP1B 0.38 6.19 0.32 1.76e-9 Obesity-related traits; CRC cis rs360798 0.512 rs2710637 chr2:63173450 G/A cg17519650 chr2:63277830 OTX1 0.46 6.52 0.34 2.65e-10 Coronary artery disease; CRC cis rs7662987 0.517 rs4235436 chr4:100039620 G/A cg13256891 chr4:100009986 ADH5 0.63 8.54 0.43 4.99e-16 Smoking initiation; CRC cis rs1218582 0.772 rs4845694 chr1:154911651 C/G cg03351412 chr1:154909251 PMVK 0.54 8.61 0.43 3.17e-16 Prostate cancer; CRC cis rs873946 0.618 rs12775767 chr10:134545628 C/T cg27286337 chr10:134555280 INPP5A 0.79 9.56 0.47 2.76e-19 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CRC cis rs17253792 0.915 rs77252471 chr14:56178075 C/T cg01858014 chr14:56050164 KTN1 -0.79 -6.09 -0.32 3.09e-9 Putamen volume; CRC cis rs17067123 0.614 rs7698554 chr4:180053504 T/C cg26610307 chr4:180072759 NA -0.54 -6.5 -0.34 3.01e-10 Response to hepatitis C treatment; CRC cis rs4253772 0.637 rs9627295 chr22:46650100 C/T cg03482458 chr22:46692211 CN5H6.4;GTSE1 0.46 6.09 0.32 3.1e-9 LDL cholesterol;Cholesterol, total; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg16179125 chr20:57582121 CTSZ 0.45 6.48 0.34 3.43e-10 Anxiety disorder; CRC cis rs6460942 1.000 rs62448563 chr7:12400040 G/A cg20607287 chr7:12443886 VWDE -0.67 -6.68 -0.35 1.01e-10 Coronary artery disease; CRC cis rs11734570 0.581 rs4461531 chr4:38603576 C/T cg18361445 chr4:38666374 KLF3;FLJ13197 0.58 7.61 0.39 2.86e-13 Inflammatory bowel disease;Crohn's disease; CRC cis rs11785400 0.793 rs4736367 chr8:143742477 G/A cg10596483 chr8:143751796 JRK 0.44 5.88 0.31 9.91e-9 Schizophrenia; CRC cis rs7085104 0.632 rs4290163 chr10:104610926 G/T cg15744005 chr10:104629667 AS3MT -0.35 -7.45 -0.38 8.13e-13 Immature fraction of reticulocytes;Schizophrenia; CRC cis rs7044106 0.762 rs1547268 chr9:123408688 T/C cg09586646 chr9:123605570 PSMD5;LOC253039 0.63 8.86 0.44 5.1e-17 Hip circumference adjusted for BMI; CRC cis rs9399137 0.507 rs56164974 chr6:135288716 C/T cg24558204 chr6:135376177 HBS1L 0.58 8.66 0.43 2.13e-16 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; CRC cis rs950169 0.580 rs11635597 chr15:85165699 C/T cg11189052 chr15:85197271 WDR73 0.64 9.38 0.46 1.12e-18 Schizophrenia; CRC cis rs6500395 0.962 rs1564979 chr16:48647017 C/A cg04672837 chr16:48644449 N4BP1 0.42 5.83 0.31 1.31e-8 Response to tocilizumab in rheumatoid arthritis; CRC cis rs3091242 0.933 rs11802413 chr1:25760920 A/G cg23205692 chr1:25664452 TMEM50A -0.44 -6.35 -0.33 7e-10 Erythrocyte sedimentation rate; CRC cis rs6499255 1.000 rs4985518 chr16:69787158 T/C cg15192750 chr16:69999425 NA 0.53 6.89 0.35 2.92e-11 IgE levels; CRC cis rs6951245 1.000 rs74887741 chr7:1110658 G/T cg26224354 chr7:1096374 C7orf50;GPR146 -0.94 -12.22 -0.56 1.5e-28 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs12024301 0.557 rs76582181 chr1:183613508 T/C cg11505048 chr1:183622726 RGL1;APOBEC4 0.81 7.14 0.37 5.93e-12 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs7927771 0.864 rs4752999 chr11:47428565 C/T cg20307385 chr11:47447363 PSMC3 -0.6 -8.5 -0.42 6.93e-16 Subjective well-being; CRC cis rs1218582 0.774 rs12036859 chr1:154859940 A/C cg03351412 chr1:154909251 PMVK -0.51 -7.59 -0.39 3.41e-13 Prostate cancer; CRC cis rs2842992 0.715 rs2277073 chr6:160182749 G/A cg11366901 chr6:160182831 ACAT2 0.96 14.04 0.61 1.98e-35 Age-related macular degeneration (geographic atrophy); CRC cis rs734999 0.505 rs4648659 chr1:2560903 T/G cg20673091 chr1:2541236 MMEL1 -0.37 -6.02 -0.32 4.56e-9 Ulcerative colitis; CRC cis rs2985684 0.901 rs7146248 chr14:50112067 C/T cg23565292 chr14:50234668 KLHDC2 -0.49 -7.05 -0.36 1.04e-11 Carotid intima media thickness; CRC cis rs6502050 0.761 rs62078754 chr17:80058666 C/T cg19223190 chr17:80058835 NA -0.51 -8.04 -0.41 1.66e-14 Life satisfaction; CRC cis rs1799949 1.000 rs8176289 chr17:41206056 T/C cg01879757 chr17:41196368 BRCA1 -0.41 -6.26 -0.33 1.24e-9 Menopause (age at onset); CRC cis rs1799949 1.000 rs4793231 chr17:41427469 A/G cg23758822 chr17:41437982 NA 0.81 13.55 0.6 1.56e-33 Menopause (age at onset); CRC cis rs1218582 0.772 rs4845688 chr1:154884142 T/C cg06221963 chr1:154839813 KCNN3 -0.76 -15.15 -0.64 1.02e-39 Prostate cancer; CRC cis rs9527 0.590 rs7901197 chr10:104840433 C/T cg15744005 chr10:104629667 AS3MT -0.29 -5.82 -0.31 1.43e-8 Arsenic metabolism; CRC cis rs6681460 0.625 rs6696812 chr1:67100309 T/C cg02459107 chr1:67143332 SGIP1 0.32 5.7 0.3 2.61e-8 Presence of antiphospholipid antibodies; CRC cis rs7215564 0.908 rs7501674 chr17:78662177 C/T cg09596252 chr17:78655493 RPTOR 0.52 5.83 0.31 1.33e-8 Myopia (pathological); CRC cis rs1862618 0.853 rs11739344 chr5:56111087 A/C cg22800045 chr5:56110881 MAP3K1 0.57 6.14 0.32 2.31e-9 Initial pursuit acceleration; CRC cis rs933688 1.000 rs2367353 chr5:90686568 G/C cg26981201 chr5:90679533 LOC100129716;ARRDC3 1.03 18.07 0.71 3.47e-51 Smoking behavior; CRC cis rs929354 0.772 rs6459737 chr7:156975136 G/A cg05182265 chr7:156933206 UBE3C -0.76 -14.51 -0.62 3.13e-37 Body mass index; CRC cis rs1348850 0.526 rs6718769 chr2:178450909 T/C cg27490568 chr2:178487706 NA 0.5 6.45 0.34 4e-10 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs514406 0.668 rs520281 chr1:53365235 G/C cg08859206 chr1:53392774 SCP2 -0.59 -9.23 -0.45 3.39e-18 Monocyte count; CRC cis rs3749237 0.595 rs6797765 chr3:49423976 A/G cg02487422 chr3:49467188 NICN1 0.44 7.11 0.36 7.49e-12 Resting heart rate; CRC cis rs172166 0.694 rs1225716 chr6:28113746 A/C cg03623178 chr6:28175578 NA 0.8 11.74 0.54 8.21e-27 Cardiac Troponin-T levels; CRC cis rs7412746 0.658 rs2864869 chr1:150734655 G/A cg18016565 chr1:150552671 MCL1 0.44 6.06 0.32 3.76e-9 Melanoma; CRC cis rs7493 0.853 rs2299266 chr7:95049073 A/G cg17330251 chr7:94953956 PON1 -0.59 -7.53 -0.38 4.83e-13 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs9902453 0.619 rs2244585 chr17:28072176 G/A cg26525008 chr17:28256777 EFCAB5;SSH2 -0.72 -12.23 -0.56 1.27e-28 Coffee consumption (cups per day); CRC cis rs12541635 0.966 rs2345070 chr8:107072027 A/G cg10147462 chr8:107024639 NA -0.45 -7.28 -0.37 2.5e-12 Age of smoking initiation; CRC cis rs9916302 0.904 rs12450559 chr17:37694709 G/A cg07936489 chr17:37558343 FBXL20 -0.84 -12.9 -0.58 4.26e-31 Glomerular filtration rate (creatinine); CRC cis rs6540559 1.000 rs6696825 chr1:209982372 A/G cg22029157 chr1:209979665 IRF6 0.61 9.36 0.46 1.29e-18 Cleft lip with or without cleft palate; CRC cis rs9399137 0.507 rs4289677 chr6:135275485 A/G cg22676075 chr6:135203613 NA 0.61 8.96 0.44 2.39e-17 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; CRC cis rs7618915 0.547 rs11130323 chr3:52770277 T/C cg08222913 chr3:52553049 STAB1 -0.34 -6.16 -0.32 2.16e-9 Bipolar disorder; CRC cis rs3796619 1.000 rs1453605 chr4:1075771 C/T cg11579758 chr4:1086637 RNF212 0.41 6.65 0.34 1.19e-10 Recombination rate (males); CRC cis rs873946 0.586 rs57431984 chr10:134567697 C/T cg27286337 chr10:134555280 INPP5A 0.82 9.97 0.48 1.25e-20 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CRC cis rs4563143 0.675 rs55976444 chr19:29265214 G/C cg12667521 chr19:29218732 NA 0.49 7.49 0.38 6.26e-13 Methadone dose in opioid dependence; CRC cis rs28386778 0.831 rs2584618 chr17:61923611 T/C cg22520471 chr17:61851767 DDX42;CCDC47 0.75 11.6 0.54 2.64e-26 Prudent dietary pattern; CRC cis rs7605827 0.930 rs11682580 chr2:15533272 T/C cg19274914 chr2:15703543 NA 0.39 5.88 0.31 9.87e-9 Educational attainment (years of education); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg16036305 chr1:115053835 TRIM33 0.46 7.33 0.37 1.85e-12 Liver disease severity in Alagille syndrome; CRC cis rs9584850 0.834 rs4294654 chr13:99119607 G/A cg07423050 chr13:99094983 FARP1 0.45 6.28 0.33 1.09e-9 Neuroticism; CRC cis rs853679 0.760 rs9393910 chr6:28208192 C/G cg15845792 chr6:28175446 NA 0.74 7.78 0.39 9.45e-14 Depression; CRC cis rs6963495 0.818 rs73192124 chr7:105171528 C/T cg13798780 chr7:105162888 PUS7 0.67 7.94 0.4 3.29e-14 Bipolar disorder (body mass index interaction); CRC cis rs3008870 0.755 rs2815366 chr1:67499930 C/T cg08660285 chr1:67390436 MIER1;WDR78 0.55 7.59 0.39 3.33e-13 Lymphocyte percentage of white cells; CRC cis rs6952808 0.792 rs2056481 chr7:1955435 A/G cg22963979 chr7:1858916 MAD1L1 -0.52 -7.7 -0.39 1.63e-13 Bipolar disorder and schizophrenia; CRC cis rs11690935 1.000 rs34542126 chr2:172542705 C/T cg13550731 chr2:172543902 DYNC1I2 1.06 19.22 0.73 1.01e-55 Schizophrenia; CRC cis rs9911578 0.813 rs8066773 chr17:56601552 A/G cg05425664 chr17:57184151 TRIM37 -0.48 -7.05 -0.36 1.06e-11 Intelligence (multi-trait analysis); CRC cis rs4481887 0.927 rs10158431 chr1:248481253 A/G cg13385794 chr1:248469461 NA 0.39 6.7 0.35 9.32e-11 Common traits (Other); CRC trans rs925098 0.577 rs2724470 chr4:17996046 A/G cg08575122 chr10:33269417 NA -0.42 -6.18 -0.32 1.93e-9 Birth weight;Height; CRC cis rs9467773 0.566 rs66972160 chr6:26359306 T/C cg14345882 chr6:26364793 BTN3A2 0.4 6.31 0.33 8.8e-10 Intelligence (multi-trait analysis); CRC cis rs8014671 0.597 rs1044527 chr14:70833819 C/G cg20409590 chr14:70655382 SLC8A3 -0.31 -6.37 -0.33 6.48e-10 Prostate cancer; CRC cis rs753778 0.629 rs2278447 chr8:142206905 G/C cg23750338 chr8:142222470 SLC45A4 0.45 7.66 0.39 2.05e-13 Reticulocyte fraction of red cells;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; CRC cis rs2243480 0.522 rs12698511 chr7:65474919 G/T cg12463550 chr7:65579703 CRCP 0.74 5.7 0.3 2.63e-8 Diabetic kidney disease; CRC cis rs10789491 0.953 rs1866770 chr1:47182468 G/T cg15501359 chr1:47185051 KIAA0494 0.76 9.15 0.45 6.19e-18 Response to hepatitis C treatment; CRC cis rs60871478 0.679 rs6962050 chr7:817201 A/G cg05535760 chr7:792225 HEATR2 1.03 13.16 0.59 4.45e-32 Cerebrospinal P-tau181p levels; CRC cis rs853679 0.517 rs7755442 chr6:28039015 T/C cg23161317 chr6:28129485 ZNF389 0.53 6.52 0.34 2.57e-10 Depression; CRC cis rs7835763 0.518 rs2445907 chr8:119106844 A/T cg11592677 chr8:119110466 EXT1 -0.4 -6.59 -0.34 1.78e-10 Autism spectrum disorder; CRC cis rs801193 1.000 rs2707845 chr7:66198798 C/T cg18876405 chr7:65276391 NA 0.6 10.62 0.51 7.84e-23 Aortic root size; CRC trans rs11098499 0.722 rs1814814 chr4:120258124 C/G cg25214090 chr10:38739885 LOC399744 0.58 9.4 0.46 9.6e-19 Corneal astigmatism; CRC cis rs801193 0.660 rs2659897 chr7:66187715 A/G cg12463550 chr7:65579703 CRCP -0.43 -5.99 -0.31 5.59e-9 Aortic root size; CRC cis rs7927592 0.913 rs6591344 chr11:68360873 G/A cg01657329 chr11:68192670 LRP5 -0.47 -6.79 -0.35 5.16e-11 Total body bone mineral density; CRC cis rs7927592 0.913 rs2282563 chr11:68333200 C/T cg16797656 chr11:68205561 LRP5 0.36 5.73 0.3 2.33e-8 Total body bone mineral density; CRC cis rs11167764 1.000 rs11167764 chr5:141479065 A/C cg08523384 chr5:141488047 NDFIP1 -0.51 -8.47 -0.42 8.2e-16 Crohn's disease; CRC cis rs1552244 1.000 rs6442147 chr3:10078247 A/G cg08888203 chr3:10149979 C3orf24 0.67 9.6 0.47 2.07e-19 Alzheimer's disease; CRC cis rs9393692 0.905 rs4412192 chr6:26290377 A/G cg00631329 chr6:26305371 NA 0.67 12.97 0.58 2.36e-31 Educational attainment; CRC cis rs7647973 0.593 rs9870755 chr3:49809841 A/G cg03060546 chr3:49711283 APEH 0.65 7.81 0.4 7.72e-14 Menarche (age at onset); CRC cis rs7551222 0.749 rs2887429 chr1:204565012 G/T cg07972458 chr1:204535000 NA 0.37 5.72 0.3 2.36e-8 Schizophrenia; CRC cis rs2281845 0.929 rs6704363 chr1:201096383 A/G cg17810781 chr1:201082982 CACNA1S 0.49 8.15 0.41 7.6e-15 Permanent tooth development; CRC cis rs2074585 0.583 rs28406958 chr15:91069364 C/A cg22089800 chr15:90895588 ZNF774 -0.41 -5.65 -0.3 3.41e-8 Basophil percentage of granulocytes;White blood cell count (basophil);Basophil percentage of white cells; CRC cis rs10905065 0.610 rs61832743 chr10:5741462 T/G cg11519256 chr10:5708881 ASB13 -0.43 -5.96 -0.31 6.53e-9 Menopause (age at onset); CRC cis rs4820294 0.669 rs7287340 chr22:38054325 C/T cg21798802 chr22:38057573 PDXP 0.35 5.68 0.3 2.93e-8 Fat distribution (HIV); CRC cis rs2197308 0.765 rs117216293 chr12:37882982 T/C cg13010199 chr12:38710504 ALG10B -0.47 -6.91 -0.36 2.51e-11 Morning vs. evening chronotype; CRC cis rs7216064 1.000 rs7212293 chr17:65847325 A/G cg12091567 chr17:66097778 LOC651250 -0.64 -7.78 -0.39 9.17e-14 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CRC cis rs7568458 0.783 rs1561198 chr2:85809989 C/T cg02493740 chr2:85810744 VAMP5 -0.38 -6.11 -0.32 2.75e-9 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); CRC cis rs4803468 1.000 rs1473248 chr19:41923314 C/T cg09537434 chr19:41945824 ATP5SL 0.97 18.62 0.72 2.39e-53 Height; CRC cis rs8031584 0.918 rs61997140 chr15:31277312 A/G cg08704250 chr15:31115839 NA -0.45 -8.25 -0.41 3.76e-15 Huntington's disease progression; CRC cis rs34172651 0.917 rs35283675 chr16:24820393 A/G cg06505273 chr16:24850292 NA 0.4 5.72 0.3 2.42e-8 Intelligence (multi-trait analysis); CRC cis rs2549003 1.000 rs10214312 chr5:131821866 T/G cg00255919 chr5:131827918 IRF1 0.59 11.92 0.55 1.77e-27 Asthma (sex interaction); CRC cis rs79387448 0.745 rs7576324 chr2:103142994 G/A cg09003973 chr2:102972529 NA 0.72 8.11 0.41 1.02e-14 Gut microbiota (bacterial taxa); CRC cis rs2404602 0.735 rs3765115 chr15:76673716 T/C cg03037974 chr15:76606532 NA -0.51 -7.76 -0.39 1.07e-13 Blood metabolite levels; CRC cis rs7727544 0.684 rs272889 chr5:131665378 A/G cg07395648 chr5:131743802 NA -0.37 -5.73 -0.3 2.28e-8 Blood metabolite levels; CRC cis rs972578 0.875 rs6519353 chr22:43356130 A/C cg01576275 chr22:43409880 NA -0.45 -7.32 -0.37 1.95e-12 Mean platelet volume; CRC cis rs10788264 0.544 rs9630110 chr10:124017308 C/T cg09507567 chr10:124027408 NA -0.34 -7.2 -0.37 4.19e-12 Total body bone mineral density; CRC cis rs6088590 1.000 rs11698977 chr20:33449691 C/T cg08999081 chr20:33150536 PIGU 0.48 8.1 0.41 1.06e-14 Coronary artery disease; CRC cis rs6696846 0.740 rs17344537 chr1:205091427 T/G cg00857998 chr1:205179979 DSTYK 0.46 6.31 0.33 8.9e-10 Red blood cell count; CRC cis rs6565180 0.926 rs4788413 chr16:30410445 C/T cg17640201 chr16:30407289 ZNF48 0.8 12.56 0.57 8.27e-30 Tonsillectomy; CRC cis rs3741151 0.686 rs73546735 chr11:73256797 C/T cg17517138 chr11:73019481 ARHGEF17 0.92 7.18 0.37 4.8e-12 GIP levels in response to oral glucose tolerance test (120 minutes); CRC cis rs1707322 1.000 rs4134387 chr1:46395158 A/T cg06784218 chr1:46089804 CCDC17 0.59 10.69 0.51 4.15e-23 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs8114671 0.562 rs4911161 chr20:33402231 C/T cg07148914 chr20:33460835 GGT7 0.36 5.78 0.3 1.74e-8 Height; CRC cis rs17401966 0.540 rs4846219 chr1:10463888 C/A cg19773385 chr1:10388646 KIF1B -0.48 -7.45 -0.38 8.24e-13 Hepatocellular carcinoma; CRC cis rs1865760 0.566 rs9467663 chr6:26021456 C/G cg18357526 chr6:26021779 HIST1H4A 0.42 5.97 0.31 6.13e-9 Height; CRC cis rs9926296 0.533 rs12102297 chr16:89812762 C/A cg04287289 chr16:89883240 FANCA 0.8 14.0 0.61 3.05e-35 Vitiligo; CRC cis rs13191362 1.000 rs13193282 chr6:163015442 T/C cg06582575 chr6:163149167 PACRG;PARK2 0.76 10.41 0.5 4.01e-22 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs6463523 0.933 rs4724821 chr7:762544 C/T cg05729249 chr7:766119 PRKAR1B;HEATR2 0.85 14.98 0.64 4.8e-39 Subjective well-being; CRC cis rs3617 0.539 rs4687687 chr3:52948332 A/G cg15147215 chr3:52552868 STAB1 0.53 9.17 0.45 5.17e-18 Red blood cell count;Autism spectrum disorder or schizophrenia; CRC cis rs870825 1.000 rs72689245 chr4:185579788 G/A cg07424746 chr4:185654737 MLF1IP -0.64 -5.98 -0.31 5.97e-9 Blood protein levels; CRC cis rs6988985 0.765 rs6431 chr8:143993765 G/A cg10324643 chr8:143916377 GML 0.36 5.87 0.31 1.08e-8 Plasma androstenedione levels in resected early stage-receptor positive breast cancer; CRC cis rs7223966 0.961 rs112709843 chr17:61836936 T/A cg23090583 chr17:61904693 PSMC5;FTSJ3 0.52 6.29 0.33 1.03e-9 Hip circumference adjusted for BMI;Body mass index; CRC cis rs6674176 0.660 rs3791112 chr1:44379248 T/G cg12908607 chr1:44402522 ARTN -0.6 -10.83 -0.51 1.4e-23 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Cognitive ability; CRC cis rs9847710 0.838 rs2581795 chr3:53038786 C/T cg04503182 chr3:53078218 SFMBT1 -0.37 -5.9 -0.31 9.07e-9 Ulcerative colitis; CRC cis rs863345 0.604 rs10908674 chr1:158503920 A/T cg12129480 chr1:158549410 OR10X1 -0.3 -6.27 -0.33 1.12e-9 Pneumococcal bacteremia; CRC cis rs10504229 0.596 rs7004566 chr8:58115602 G/C cg02290350 chr8:58132656 NA -0.58 -8.16 -0.41 7.29e-15 Developmental language disorder (linguistic errors); CRC cis rs6121246 0.512 rs6058384 chr20:30276409 A/T cg13852791 chr20:30311386 BCL2L1 0.71 13.66 0.6 6.07e-34 Mean corpuscular hemoglobin; CRC cis rs9549367 0.713 rs2476319 chr13:113836519 C/T cg18105134 chr13:113819100 PROZ 0.85 13.44 0.6 3.84e-33 Platelet distribution width; CRC cis rs3018066 0.836 rs10000428 chr4:107096708 A/G cg01869342 chr4:106983673 TBCK 0.37 5.7 0.3 2.6e-8 Cancer; CRC cis rs67311347 0.544 rs9868700 chr3:40345408 G/A cg09455208 chr3:40491958 NA 0.32 6.41 0.33 4.94e-10 Renal cell carcinoma; CRC cis rs9916302 0.904 rs4511574 chr17:37532916 A/G cg00129232 chr17:37814104 STARD3 -0.5 -7.46 -0.38 8.03e-13 Glomerular filtration rate (creatinine); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg20905760 chr15:43478003 CCNDBP1 0.43 6.02 0.31 4.61e-9 Response to antipsychotic treatment; CRC cis rs7412746 0.611 rs72704679 chr1:150897477 C/T cg10589385 chr1:150898437 SETDB1 0.27 5.94 0.31 7.06e-9 Melanoma; CRC cis rs10504229 0.728 rs72650860 chr8:58153111 A/G cg02725872 chr8:58115012 NA -0.57 -9.07 -0.45 1.09e-17 Developmental language disorder (linguistic errors); CRC cis rs10751667 0.643 rs10794352 chr11:946294 T/C cg01483505 chr11:975446 AP2A2 0.44 7.34 0.37 1.74e-12 Alzheimer's disease (late onset); CRC cis rs7914558 1.000 rs10883837 chr10:104896486 G/A cg15744005 chr10:104629667 AS3MT -0.34 -7.27 -0.37 2.57e-12 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs2836974 0.897 rs6517513 chr21:40526878 A/G cg17971929 chr21:40555470 PSMG1 0.84 12.96 0.58 2.62e-31 Cognitive function; CRC trans rs11039798 0.841 rs7950737 chr11:48590678 T/G cg03929089 chr4:120376271 NA 0.64 6.24 0.33 1.38e-9 Axial length; CRC cis rs11098499 0.708 rs10005237 chr4:120237897 T/C cg09307838 chr4:120376055 NA 0.62 9.75 0.47 6.92e-20 Corneal astigmatism; CRC cis rs2303745 0.589 rs891018 chr19:17396761 C/T cg02221750 chr19:17393354 ANKLE1 0.44 6.63 0.34 1.36e-10 Systemic lupus erythematosus; CRC cis rs9902453 0.934 rs7223645 chr17:28491029 A/T cg26525008 chr17:28256777 EFCAB5;SSH2 0.58 9.14 0.45 6.58e-18 Coffee consumption (cups per day); CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg09192942 chr16:75682004 KARS;TERF2IP 0.42 6.61 0.34 1.54e-10 Obesity-related traits; CRC cis rs713477 0.505 rs9635232 chr14:55887880 T/C cg13175173 chr14:55914753 NA -0.45 -7.44 -0.38 9.1e-13 Pediatric bone mineral content (femoral neck); CRC cis rs294883 0.858 rs10806703 chr6:159701580 G/C cg14500486 chr6:159655392 FNDC1 -0.35 -5.75 -0.3 2.09e-8 Coronary artery disease; CRC cis rs11190604 0.945 rs7091356 chr10:102292268 G/C cg16342193 chr10:102329863 NA -0.36 -5.94 -0.31 7.21e-9 Palmitoleic acid (16:1n-7) levels; CRC cis rs9560113 1.000 rs9560110 chr13:112181233 C/T cg10483660 chr13:112241077 NA 0.36 5.79 0.3 1.63e-8 Menarche (age at onset); CRC cis rs8072100 0.875 rs12451409 chr17:45544856 A/G cg25173405 chr17:45401733 C17orf57 -0.43 -6.57 -0.34 1.99e-10 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs12760731 0.720 rs10913552 chr1:178411543 G/A cg00404053 chr1:178313656 RASAL2 0.86 10.25 0.49 1.36e-21 Obesity-related traits; CRC trans rs2018683 0.870 rs13232487 chr7:28985119 C/A cg19402173 chr7:128379420 CALU -0.57 -8.6 -0.43 3.3e-16 Response to irinotecan and platinum-based chemotherapy in non-small-cell lung cancer; CRC cis rs875971 0.830 rs28714531 chr7:65968237 G/A cg00343986 chr7:65444356 GUSB 0.45 6.26 0.33 1.19e-9 Aortic root size; CRC trans rs2303319 0.504 rs62189042 chr2:162602320 G/T cg20024234 chr21:43431083 ZNF295 -0.66 -5.99 -0.31 5.57e-9 Cognitive function; CRC cis rs7927771 0.725 rs11039265 chr11:47523214 C/A cg18512352 chr11:47633146 NA -0.48 -9.63 -0.47 1.67e-19 Subjective well-being; CRC cis rs1065656 0.581 rs1065663 chr16:1839023 G/A cg03013636 chr16:1946785 NA -0.48 -6.04 -0.32 4.28e-9 Insulin-like growth factors; CRC cis rs6499255 0.951 rs11642030 chr16:69605211 A/C cg15192750 chr16:69999425 NA 0.58 7.76 0.39 1.11e-13 IgE levels; CRC cis rs3087591 1.000 rs7406983 chr17:29703374 G/A cg24425628 chr17:29625626 OMG;NF1 -0.88 -17.12 -0.69 2e-47 Hip circumference; CRC trans rs10988802 0.683 rs12343296 chr9:98398777 C/T cg03817673 chr4:189065399 TRIML1 -0.56 -6.01 -0.31 5.04e-9 Chemerin levels; CRC cis rs6502050 0.835 rs67149434 chr17:80128007 G/A cg13198984 chr17:80129470 CCDC57 0.46 8.13 0.41 9e-15 Life satisfaction; CRC cis rs1008375 0.902 rs6844984 chr4:17651304 C/G cg02297831 chr4:17616191 MED28 0.49 6.62 0.34 1.46e-10 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs8077889 0.917 rs9894873 chr17:41911832 A/G cg16892393 chr17:41919603 NA 0.5 7.46 0.38 7.66e-13 Triglycerides; CRC cis rs9393777 0.513 rs6913660 chr6:27091425 C/A cg12292205 chr6:26970375 C6orf41 -0.78 -8.55 -0.43 4.73e-16 Intelligence (multi-trait analysis); CRC cis rs897984 0.609 rs11862744 chr16:31057800 G/A cg02466173 chr16:30829666 NA -0.6 -9.02 -0.45 1.59e-17 Dementia with Lewy bodies; CRC cis rs2019137 0.560 rs10206269 chr2:113990393 C/A cg07594247 chr2:113993304 PAX8;LOC440839;LOC654433 0.5 7.56 0.38 4.1e-13 Lymphocyte counts; CRC cis rs2762353 0.595 rs1892256 chr6:25754271 C/T cg07061783 chr6:25882402 NA 0.5 6.39 0.33 5.67e-10 Blood metabolite levels; CRC trans rs10983614 1.000 rs7867776 chr9:120072627 A/G cg26326168 chr12:133405726 GOLGA3 0.45 6.37 0.33 6.52e-10 Survival in pancreatic cancer; CRC cis rs10193935 0.901 rs17029344 chr2:42444287 T/C cg27598129 chr2:42591480 NA -0.71 -8.07 -0.41 1.36e-14 Colonoscopy-negative controls vs population controls; CRC cis rs6740322 0.748 rs6756625 chr2:43489313 C/T cg06169590 chr2:43455088 ZFP36L2;LOC100129726 0.68 8.68 0.43 1.9e-16 Coronary artery disease; CRC cis rs4604732 0.536 rs12058821 chr1:247649651 G/T cg12758973 chr1:247694275 LOC148824;OR2C3 0.44 6.37 0.33 6.32e-10 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CRC cis rs853679 0.760 rs9357067 chr6:28210293 C/G cg02683197 chr6:28174875 NA 0.64 6.54 0.34 2.37e-10 Depression; CRC cis rs1691799 0.867 rs1168333 chr12:66761377 G/A cg16791601 chr12:66731901 HELB -0.68 -11.33 -0.53 2.36e-25 White blood cell count (basophil); CRC cis rs28386778 0.799 rs2955234 chr17:61983601 A/C cg22520471 chr17:61851767 DDX42;CCDC47 -0.66 -9.95 -0.48 1.4e-20 Prudent dietary pattern; CRC trans rs12478296 1.000 rs12474070 chr2:243039738 C/T cg18288967 chr1:45987694 PRDX1 0.68 7.48 0.38 6.93e-13 Obesity-related traits; CRC cis rs2075371 0.966 rs2544225 chr7:133995838 A/C cg20476274 chr7:133979776 SLC35B4 0.82 14.91 0.64 8.83e-39 Mean platelet volume; CRC cis rs172166 0.769 rs149965 chr6:28018689 T/A cg10876282 chr6:28092338 ZSCAN16 0.49 6.62 0.34 1.45e-10 Cardiac Troponin-T levels; CRC cis rs1799949 1.000 rs34942571 chr17:41273379 G/C cg19454999 chr17:41278357 BRCA1;NBR2 0.53 8.21 0.41 4.99e-15 Menopause (age at onset); CRC cis rs4843747 0.573 rs7499959 chr16:88110422 C/G cg17633681 chr16:88106987 BANP 0.72 12.29 0.56 7.63e-29 Menopause (age at onset); CRC cis rs2249694 0.919 rs10857768 chr10:135402703 A/G cg20169779 chr10:135381914 SYCE1 -0.68 -11.67 -0.54 1.47e-26 Obesity-related traits; CRC cis rs10504229 0.728 rs78765835 chr8:58154337 A/G cg11062466 chr8:58055876 NA 0.45 6.11 0.32 2.74e-9 Developmental language disorder (linguistic errors); CRC cis rs6570726 0.935 rs428659 chr6:145827039 T/C cg05347473 chr6:146136440 FBXO30 0.37 6.0 0.31 5.27e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs7224737 0.956 rs7208907 chr17:40284783 C/T cg02450064 chr17:40260053 DHX58 -0.43 -6.24 -0.33 1.38e-9 Fibrinogen levels; CRC trans rs7937682 0.889 rs10789844 chr11:111579109 A/T cg18187862 chr3:45730750 SACM1L 0.48 6.95 0.36 1.92e-11 Primary sclerosing cholangitis; CRC cis rs769267 1.000 rs2301669 chr19:19453560 C/A cg03709012 chr19:19516395 GATAD2A -0.67 -10.31 -0.49 9.07e-22 Tonsillectomy; CRC cis rs7772486 0.720 rs991507 chr6:146023609 G/A cg23711669 chr6:146136114 FBXO30 -0.75 -12.8 -0.58 1e-30 Lobe attachment (rater-scored or self-reported); CRC cis rs853679 0.517 rs4713135 chr6:28039586 G/A cg12172441 chr6:28176163 NA 0.6 7.21 0.37 3.76e-12 Depression; CRC cis rs28830936 0.966 rs890498 chr15:42111298 C/G cg17847044 chr15:42102381 MAPKBP1 -0.32 -6.49 -0.34 3.2e-10 Diastolic blood pressure; CRC cis rs8062405 0.965 rs8049439 chr16:28837515 A/G cg16576597 chr16:28551801 NUPR1 0.4 5.89 0.31 9.68e-9 Cognitive ability (multi-trait analysis);Cognitive ability; CRC cis rs1915146 0.546 rs2681919 chr10:126859029 A/G cg23000734 chr10:126850823 CTBP2 0.56 7.85 0.4 5.82e-14 Menarche (age at onset); CRC cis rs2153535 0.504 rs9405393 chr6:8467432 G/T cg07606381 chr6:8435919 SLC35B3 0.68 10.9 0.51 8.26e-24 Motion sickness; CRC cis rs2243480 1.000 rs781156 chr7:65479141 C/A cg25985355 chr7:65971099 NA -0.48 -5.61 -0.3 4.24e-8 Diabetic kidney disease; CRC cis rs4474465 0.915 rs11237505 chr11:78171261 A/G cg27205649 chr11:78285834 NARS2 -0.48 -5.94 -0.31 7.15e-9 Alzheimer's disease (survival time); CRC cis rs7829975 0.846 rs1879957 chr8:8544808 T/C cg06636001 chr8:8085503 FLJ10661 -0.59 -9.45 -0.46 6.72e-19 Mood instability; CRC cis rs10791323 0.569 rs2282602 chr11:133714522 G/A cg06766960 chr11:133703094 NA -0.36 -5.91 -0.31 8.55e-9 Childhood ear infection; CRC cis rs7178572 0.568 rs4886862 chr15:77652368 T/C cg22256960 chr15:77711686 NA -0.59 -8.39 -0.42 1.48e-15 Type 2 diabetes; CRC cis rs62064224 0.714 rs4794917 chr17:30636146 C/G cg12855166 chr17:30846586 MYO1D -0.38 -6.44 -0.33 4.27e-10 Schizophrenia; CRC cis rs2455601 1.000 rs12418190 chr11:8899818 G/C cg21881798 chr11:8931708 C11orf17;ST5 -0.55 -5.73 -0.3 2.25e-8 Schizophrenia; CRC cis rs11212617 1.000 rs228591 chr11:108097333 A/G cg12106634 chr11:108092400 ATM;NPAT 0.46 6.78 0.35 5.56e-11 Response to metformin in type 2 diabetes (glycemic); CRC trans rs12599106 0.792 rs76039834 chr16:34598453 G/A cg07332563 chr6:291687 DUSP22 -0.48 -6.93 -0.36 2.27e-11 Menopause (age at onset); CRC trans rs1814175 0.817 rs1621090 chr11:49895868 C/A cg03929089 chr4:120376271 NA -0.98 -19.31 -0.73 4.62e-56 Height; CRC cis rs4665809 1.000 rs1550382 chr2:26266877 T/G cg26119090 chr2:26468346 HADHA;HADHB -0.62 -7.99 -0.4 2.23e-14 Gut microbiome composition (summer); CRC cis rs4713118 0.869 rs9283881 chr6:27715255 A/T cg08798685 chr6:27730294 NA -0.42 -6.22 -0.32 1.51e-9 Parkinson's disease; CRC cis rs2274273 0.624 rs8015211 chr14:55841447 A/G cg10130446 chr14:55658398 DLGAP5 -0.41 -5.71 -0.3 2.49e-8 Protein biomarker; CRC cis rs1862618 0.853 rs10461617 chr5:56104308 A/G cg20203395 chr5:56204925 C5orf35 -0.69 -8.14 -0.41 8.04e-15 Initial pursuit acceleration; CRC cis rs3106136 0.934 rs4693004 chr4:95168456 G/A cg11021082 chr4:95130006 SMARCAD1 -0.46 -7.15 -0.37 5.67e-12 Capecitabine sensitivity; CRC cis rs832540 0.931 rs832534 chr5:56213672 G/A cg12311346 chr5:56204834 C5orf35 -0.53 -8.13 -0.41 9.05e-15 Coronary artery disease; CRC cis rs7726839 0.507 rs111707179 chr5:593308 T/A cg09021430 chr5:549028 NA -0.72 -8.33 -0.42 2.23e-15 Obesity-related traits; CRC cis rs13191362 1.000 rs34637087 chr6:163004064 T/G cg23758597 chr6:163146217 PARK2 -0.55 -6.13 -0.32 2.54e-9 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC trans rs61931739 0.500 rs11053177 chr12:34412829 G/A cg26384229 chr12:38710491 ALG10B 0.61 8.99 0.44 2.05e-17 Morning vs. evening chronotype; CRC cis rs422249 0.547 rs174537 chr11:61552680 G/T cg00603274 chr11:61596626 FADS2 -0.46 -6.66 -0.34 1.15e-10 Trans fatty acid levels; CRC cis rs4731207 0.596 rs1842615 chr7:124582871 A/G cg23710748 chr7:124431027 NA -0.38 -6.08 -0.32 3.25e-9 Cutaneous malignant melanoma; CRC cis rs6665290 0.904 rs1045252 chr1:227181555 A/G cg10327440 chr1:227177885 CDC42BPA -1.04 -23.79 -0.8 1.7e-73 Myeloid white cell count; CRC cis rs2404602 0.647 rs10851889 chr15:77023336 C/T cg03037974 chr15:76606532 NA -0.54 -8.2 -0.41 5.41e-15 Blood metabolite levels; CRC cis rs6758955 0.850 rs73161279 chr2:10481001 T/G cg15773312 chr2:10472214 HPCAL1 -0.82 -9.63 -0.47 1.66e-19 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; CRC cis rs7493 0.755 rs740264 chr7:95021803 T/G cg04155289 chr7:94953770 PON1 -0.58 -7.08 -0.36 8.65e-12 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs73058052 0.597 rs7249925 chr19:50093572 A/G cg15963326 chr19:50037085 RCN3 -0.36 -5.71 -0.3 2.59e-8 Fibrinogen levels; CRC cis rs6952808 0.723 rs1107592 chr7:2041432 C/T cg22963979 chr7:1858916 MAD1L1 0.45 6.8 0.35 4.91e-11 Bipolar disorder and schizophrenia; CRC trans rs1728785 0.892 rs1103955 chr16:68588488 T/G cg04657470 chr2:198365150 HSPE1;HSPD1 0.59 7.1 0.36 7.97e-12 Ulcerative colitis; CRC cis rs7647973 1.000 rs73088137 chr3:49448423 G/A cg07690219 chr3:49449608 TCTA;RHOA 0.52 5.71 0.3 2.5e-8 Menarche (age at onset); CRC cis rs9787249 0.957 rs3738673 chr1:40204823 C/T cg02773041 chr1:40204384 PPIE 0.63 9.23 0.45 3.51e-18 Blood protein levels; CRC cis rs7474896 0.537 rs2472149 chr10:38262196 A/C cg25427524 chr10:38739819 LOC399744 0.59 7.18 0.37 4.66e-12 Obesity (extreme); CRC cis rs1008375 1.000 rs2109522 chr4:17658645 T/A cg02297831 chr4:17616191 MED28 0.44 5.79 0.3 1.62e-8 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs3806843 1.000 rs1476768 chr5:140173597 G/A cg19875535 chr5:140030758 IK 0.6 9.84 0.48 3.35e-20 Depressive symptoms (multi-trait analysis); CRC cis rs4731207 0.698 rs4731216 chr7:124466512 T/G cg23710748 chr7:124431027 NA 0.38 6.08 0.32 3.42e-9 Cutaneous malignant melanoma; CRC cis rs4820539 0.934 rs3788348 chr22:23467946 G/C cg14186256 chr22:23484241 RTDR1 0.92 18.25 0.71 6.78e-52 Bone mineral density; CRC cis rs7666738 0.830 rs13145011 chr4:98993410 G/A cg17366294 chr4:99064904 C4orf37 0.44 7.39 0.38 1.19e-12 Colonoscopy-negative controls vs population controls; CRC trans rs12517041 1.000 rs7722738 chr5:23288074 T/C ch.8.1293020R chr8:59333349 UBXN2B -0.55 -6.17 -0.32 1.96e-9 Calcium levels; CRC cis rs7914558 1.000 rs1926030 chr10:104855656 T/C cg04362960 chr10:104952993 NT5C2 0.6 9.09 0.45 9.86e-18 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs4927850 0.709 rs6765762 chr3:195652851 G/A cg00031303 chr3:195681400 NA 0.72 9.64 0.47 1.51e-19 Pancreatic cancer; CRC cis rs3011225 0.691 rs3791102 chr1:44366617 C/T cg12908607 chr1:44402522 ARTN -0.5 -9.08 -0.45 1.04e-17 Amyotrophic lateral sclerosis (age of onset); CRC cis rs2645694 0.651 rs2703144 chr4:77830505 C/G cg10057126 chr4:77819792 ANKRD56 0.34 5.7 0.3 2.64e-8 Emphysema distribution in smoking; CRC cis rs17270561 0.609 rs9358879 chr6:25742918 C/G cg17691542 chr6:26056736 HIST1H1C 0.72 9.24 0.45 3.07e-18 Iron status biomarkers; CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg08862778 chr1:11322643 MTOR -0.52 -6.42 -0.33 4.64e-10 Diisocyanate-induced asthma; CRC cis rs6912958 1.000 rs9294379 chr6:88152535 C/A cg08069147 chr6:88032118 GJB7;C6orf162 -0.62 -9.49 -0.46 4.74e-19 Monocyte percentage of white cells; CRC cis rs9733 0.566 rs72702554 chr1:150678234 A/G cg10589385 chr1:150898437 SETDB1 0.29 6.08 0.32 3.29e-9 Tonsillectomy; CRC cis rs7605827 0.930 rs879972 chr2:15703031 G/C cg19274914 chr2:15703543 NA 0.37 5.62 0.3 4.13e-8 Educational attainment (years of education); CRC cis rs950169 0.919 rs12915589 chr15:84734464 T/C cg11189052 chr15:85197271 WDR73 0.61 8.81 0.44 7.07e-17 Schizophrenia; CRC cis rs11212617 0.837 rs10890822 chr11:108027060 C/A cg14761454 chr11:108092087 ATM;NPAT 0.44 6.73 0.35 7.65e-11 Response to metformin in type 2 diabetes (glycemic); CRC cis rs4665809 0.590 rs35615763 chr2:26468778 C/G cg25036284 chr2:26402008 FAM59B 0.61 7.76 0.39 1.09e-13 Gut microbiome composition (summer); CRC cis rs6964587 0.843 rs56075286 chr7:91731518 G/A cg17063962 chr7:91808500 NA 0.83 14.55 0.63 2.2e-37 Breast cancer; CRC cis rs853679 0.517 rs17711801 chr6:28092307 C/G cg23161317 chr6:28129485 ZNF389 0.53 6.54 0.34 2.37e-10 Depression; CRC cis rs7705042 0.727 rs1062158 chr5:141523000 C/T cg07392085 chr5:141489673 NDFIP1 0.45 7.26 0.37 2.75e-12 Asthma; CRC cis rs2153535 0.580 rs6921964 chr6:8446395 A/G cg21535247 chr6:8435926 SLC35B3 0.5 7.51 0.38 5.76e-13 Motion sickness; CRC cis rs28386778 0.863 rs2251164 chr17:61884120 G/A cg22520471 chr17:61851767 DDX42;CCDC47 0.75 11.69 0.54 1.18e-26 Prudent dietary pattern; CRC cis rs7786808 0.530 rs7785656 chr7:158184164 C/G cg01191920 chr7:158217561 PTPRN2 -0.66 -10.72 -0.51 3.42e-23 Obesity-related traits; CRC cis rs2019137 0.936 rs12612729 chr2:113957048 G/A cg07772999 chr2:113993052 PAX8;LOC440839;LOC654433 -0.45 -6.34 -0.33 7.78e-10 Lymphocyte counts; CRC cis rs79387448 0.745 rs7601773 chr2:103120483 G/T cg09003973 chr2:102972529 NA 0.68 7.56 0.38 3.99e-13 Gut microbiota (bacterial taxa); CRC cis rs12477438 0.501 rs12619780 chr2:99707307 C/T cg26064155 chr2:99771622 LIPT1;TSGA10 0.82 14.23 0.62 3.79e-36 Chronic sinus infection; CRC cis rs9807989 0.507 rs2293224 chr2:103035779 T/C cg03938978 chr2:103052716 IL18RAP 0.59 10.13 0.49 3.5e-21 Asthma; CRC cis rs8060686 0.641 rs76053508 chr16:68243054 A/T cg26727032 chr16:67993705 SLC12A4 -0.55 -6.31 -0.33 9.13e-10 HDL cholesterol;Metabolic syndrome; CRC cis rs11971779 0.648 rs59791374 chr7:139116962 C/T cg07862535 chr7:139043722 LUC7L2 0.72 8.88 0.44 4.31e-17 Diisocyanate-induced asthma; CRC cis rs6502050 0.799 rs6502066 chr17:80103737 T/C cg02741985 chr17:80059408 CCDC57 0.43 7.15 0.37 5.66e-12 Life satisfaction; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg08235057 chr22:21057110 TMEM191A 0.45 6.43 0.33 4.45e-10 Response to antipsychotic treatment; CRC trans rs1814175 0.817 rs12290508 chr11:49621037 C/T cg03929089 chr4:120376271 NA -0.94 -17.66 -0.7 1.52e-49 Height; CRC cis rs1552244 1.000 rs9845756 chr3:10067548 G/C cg16606324 chr3:10149918 C3orf24 0.69 9.36 0.46 1.3e-18 Alzheimer's disease; CRC cis rs6662572 0.853 rs2065708 chr1:45977685 A/G cg08644498 chr1:46502608 NA 0.4 5.78 0.3 1.72e-8 Blood protein levels; CRC cis rs7927771 0.965 rs1064608 chr11:47640429 G/C cg20307385 chr11:47447363 PSMC3 -0.55 -7.7 -0.39 1.65e-13 Subjective well-being; CRC cis rs172166 0.516 rs2021826 chr6:28132756 G/A cg25164649 chr6:28176230 NA 0.47 6.95 0.36 2e-11 Cardiac Troponin-T levels; CRC cis rs1552244 0.572 rs3843008 chr3:10173742 C/T cg13047869 chr3:10149882 C3orf24 0.56 5.99 0.31 5.53e-9 Alzheimer's disease; CRC cis rs9925964 0.748 rs4889603 chr16:30982225 C/T cg02466173 chr16:30829666 NA -0.42 -5.88 -0.31 9.85e-9 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs757110 0.834 rs1002226 chr11:17405617 C/T cg15432903 chr11:17409602 KCNJ11 0.72 11.72 0.54 9.64e-27 Type 2 diabetes; CRC cis rs4713118 0.662 rs149947 chr6:27972433 A/T cg23161317 chr6:28129485 ZNF389 0.44 5.96 0.31 6.45e-9 Parkinson's disease; CRC cis rs2976388 0.609 rs2585152 chr8:143786214 A/T cg15511327 chr8:143859410 LYNX1 0.41 7.33 0.37 1.84e-12 Urinary tract infection frequency; CRC cis rs875971 1.000 rs6979382 chr7:65886375 C/T cg11764359 chr7:65958608 NA 0.62 9.99 0.48 1.05e-20 Aortic root size; CRC cis rs7155603 0.700 rs17103360 chr14:75959341 A/G cg01624173 chr14:75981868 NA 0.46 5.71 0.3 2.57e-8 Rheumatoid arthritis; CRC cis rs4642101 0.597 rs12638595 chr3:12819281 T/C cg24848339 chr3:12840334 CAND2 0.31 5.71 0.3 2.55e-8 QRS complex (12-leadsum); CRC cis rs12928939 0.768 rs71386932 chr16:71816191 G/A cg08717414 chr16:71523259 ZNF19 -0.51 -6.35 -0.33 7.13e-10 Post bronchodilator FEV1; CRC cis rs9287719 0.967 rs6432121 chr2:10753804 G/C cg00105475 chr2:10696890 NA 0.45 7.22 0.37 3.59e-12 Prostate cancer; CRC cis rs6860806 0.507 rs272868 chr5:131680751 C/G cg09877947 chr5:131593287 PDLIM4 0.43 7.07 0.36 9.28e-12 Breast cancer; CRC cis rs4481887 0.893 rs10788774 chr1:248471712 T/C cg00666640 chr1:248458726 OR2T12 0.52 9.1 0.45 8.75e-18 Common traits (Other); CRC trans rs3942852 0.774 rs2279823 chr11:48146092 T/C cg15704280 chr7:45808275 SEPT13 -0.58 -7.27 -0.37 2.56e-12 Acute lymphoblastic leukemia (childhood); CRC cis rs17818399 0.547 rs7607633 chr2:46759427 T/C cg26688816 chr2:46740690 ATP6V1E2 -0.51 -6.46 -0.34 3.76e-10 Height; CRC cis rs7666738 0.830 rs62321564 chr4:98976496 C/G cg17366294 chr4:99064904 C4orf37 0.44 7.44 0.38 8.98e-13 Colonoscopy-negative controls vs population controls; CRC trans rs2840044 0.711 rs225301 chr17:33922411 T/A cg19694781 chr19:47549865 TMEM160 -0.66 -9.65 -0.47 1.48e-19 Response to radiotherapy in cancer (late toxicity); CRC cis rs17270561 0.541 rs12192932 chr6:25911502 A/G cg17691542 chr6:26056736 HIST1H1C 0.9 10.76 0.51 2.49e-23 Iron status biomarkers; CRC cis rs6860806 0.507 rs272883 chr5:131668698 A/G cg20512303 chr5:131592959 PDLIM4 0.38 6.68 0.35 1.01e-10 Breast cancer; CRC cis rs4654899 0.802 rs9651021 chr1:21222770 A/C cg02927042 chr1:21476669 EIF4G3 -0.51 -8.08 -0.41 1.21e-14 Superior frontal gyrus grey matter volume; CRC cis rs1046896 1.000 rs1046917 chr17:80685655 A/G cg19046167 chr17:80928561 B3GNTL1 -0.4 -6.27 -0.33 1.12e-9 Glycated hemoglobin levels; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg09866119 chr4:4291695 LYAR;ZNF509 0.45 6.26 0.33 1.2e-9 Response to antipsychotic treatment; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg00170564 chr12:107714106 BTBD11 0.46 6.27 0.33 1.15e-9 Thyroid stimulating hormone; CRC cis rs951366 0.764 rs708725 chr1:205744138 G/T cg23034840 chr1:205782522 SLC41A1 0.48 6.7 0.35 9.11e-11 Menarche (age at onset); CRC cis rs728616 0.867 rs7893241 chr10:81954338 C/T cg05935833 chr10:81318306 SFTPA2 -0.71 -7.59 -0.39 3.34e-13 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs7618501 0.571 rs2240329 chr3:50107512 G/A cg24110177 chr3:50126178 RBM5 0.52 8.13 0.41 8.79e-15 Intelligence (multi-trait analysis); CRC cis rs2204008 0.591 rs11495396 chr12:38380182 C/T cg13010199 chr12:38710504 ALG10B 0.47 6.3 0.33 9.3e-10 Bladder cancer; CRC cis rs7918232 0.567 rs11015463 chr10:27319258 A/G cg14442939 chr10:27389572 ANKRD26 0.61 6.69 0.35 9.74e-11 Breast cancer; CRC cis rs3749237 0.555 rs7637665 chr3:49552295 T/C cg07636037 chr3:49044803 WDR6 0.55 7.9 0.4 4.3e-14 Resting heart rate; CRC cis rs4665809 0.567 rs6546848 chr2:26444414 G/C cg25036284 chr2:26402008 FAM59B -0.65 -8.57 -0.43 4.22e-16 Gut microbiome composition (summer); CRC cis rs75804782 0.641 rs11885523 chr2:239344263 G/A cg18131467 chr2:239335373 ASB1 -0.71 -6.32 -0.33 8.61e-10 Morning vs. evening chronotype;Chronotype; CRC cis rs853679 0.546 rs34295134 chr6:27828151 T/A cg23259851 chr6:27775964 HIST1H2AI;HIST1H2BL 0.68 5.8 0.3 1.6e-8 Depression; CRC cis rs10788264 0.621 rs9633734 chr10:124057667 T/C cg09507567 chr10:124027408 NA 0.32 7.06 0.36 1.02e-11 Total body bone mineral density; CRC cis rs713477 1.000 rs7149622 chr14:55909402 T/C cg13175173 chr14:55914753 NA -0.52 -9.85 -0.48 3.19e-20 Pediatric bone mineral content (femoral neck); CRC cis rs875971 1.000 rs6958271 chr7:65979331 A/C cg18876405 chr7:65276391 NA 0.51 8.81 0.44 7.27e-17 Aortic root size; CRC cis rs311392 0.554 rs311390 chr8:55102401 G/A cg06042504 chr8:55087323 NA -0.37 -6.0 -0.31 5.25e-9 Pelvic organ prolapse (moderate/severe); CRC cis rs6840360 0.615 rs12647586 chr4:152607568 G/C cg09659197 chr4:152720779 NA 0.4 7.97 0.4 2.62e-14 Intelligence (multi-trait analysis); CRC cis rs780096 0.546 rs1060525 chr2:27635582 A/G cg21248554 chr2:27665150 KRTCAP3 -0.3 -6.97 -0.36 1.76e-11 Total body bone mineral density; CRC cis rs7901135 1.000 rs1121644 chr10:60587139 C/T cg23799393 chr10:60588674 BICC1 0.39 5.91 0.31 8.61e-9 Morning vs. evening chronotype; CRC cis rs10479542 0.896 rs4701130 chr5:178982416 C/T cg14820908 chr5:178986412 RUFY1 -0.39 -6.72 -0.35 7.92e-11 Lung cancer; CRC cis rs2836974 0.932 rs2836953 chr21:40617483 G/A cg17971929 chr21:40555470 PSMG1 0.84 12.87 0.58 5.82e-31 Cognitive function; CRC cis rs951366 0.617 rs9438393 chr1:205782718 A/G cg07167872 chr1:205819463 PM20D1 0.98 17.41 0.69 1.4e-48 Menarche (age at onset); CRC cis rs2535633 0.602 rs6801235 chr3:53009595 T/C cg11645453 chr3:52864694 ITIH4 0.41 7.73 0.39 1.35e-13 Body mass index; CRC cis rs1448094 0.621 rs10863090 chr12:86282211 C/T cg02569458 chr12:86230093 RASSF9 0.38 6.29 0.33 9.9e-10 Major depressive disorder; CRC cis rs9611565 0.559 rs5751160 chr22:42175695 A/G cg06481639 chr22:41940642 POLR3H 0.55 6.05 0.32 3.97e-9 Vitiligo; CRC cis rs992157 0.560 rs6436047 chr2:219108913 A/C cg04731861 chr2:219085781 ARPC2 -0.37 -7.88 -0.4 4.82e-14 Colorectal cancer; CRC cis rs4731207 0.596 rs1531716 chr7:124638538 A/G cg23710748 chr7:124431027 NA -0.39 -6.27 -0.33 1.15e-9 Cutaneous malignant melanoma; CRC cis rs4660306 0.744 rs11583290 chr1:45926363 C/T cg03123370 chr1:45965343 CCDC163P;MMACHC 0.52 6.97 0.36 1.71e-11 Homocysteine levels; CRC cis rs600806 0.815 rs4970730 chr1:109979526 T/C cg23032129 chr1:109941072 SORT1 -0.27 -5.8 -0.3 1.57e-8 Intelligence (multi-trait analysis); CRC cis rs7845219 0.544 rs10956932 chr8:95948202 C/T cg23172400 chr8:95962367 TP53INP1 0.35 5.73 0.3 2.33e-8 Type 2 diabetes; CRC cis rs595982 0.527 rs55670257 chr19:49382654 G/A cg21252483 chr19:49399788 TULP2 -0.42 -6.48 -0.34 3.31e-10 Red cell distribution width; CRC cis rs1401999 0.628 rs1520195 chr3:183736882 G/A cg20387954 chr3:183756860 HTR3D 0.37 6.47 0.34 3.64e-10 Anterior chamber depth; CRC trans rs1005277 0.565 rs2474565 chr10:38380828 A/G cg23533926 chr12:111358616 MYL2 -0.52 -7.83 -0.4 6.69e-14 Extrinsic epigenetic age acceleration; CRC cis rs2396545 0.638 rs1062099 chr11:567627 G/C cg03909863 chr11:638404 DRD4 -0.45 -5.6 -0.3 4.42e-8 Systemic lupus erythematosus and Systemic sclerosis; CRC cis rs929596 0.785 rs6747843 chr2:234664354 G/A cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.73 -10.53 -0.5 1.56e-22 Total bilirubin levels in HIV-1 infection; CRC cis rs8060686 0.920 rs111315946 chr16:67889793 G/C cg07125278 chr16:67683757 RLTPR -0.61 -6.97 -0.36 1.7e-11 HDL cholesterol;Metabolic syndrome; CRC trans rs2228479 0.571 rs62052183 chr16:89966921 C/A cg21302420 chr1:112162376 RAP1A 0.7 6.61 0.34 1.52e-10 Skin colour saturation; CRC cis rs1448094 0.511 rs7139088 chr12:86147878 T/C cg00310523 chr12:86230176 RASSF9 -0.36 -5.92 -0.31 8.25e-9 Major depressive disorder; CRC cis rs274567 0.550 rs272885 chr5:131667736 A/G cg22638593 chr5:131593259 PDLIM4 0.38 6.34 0.33 7.78e-10 Blood metabolite levels; CRC cis rs6502050 0.769 rs9904237 chr17:80119664 G/A cg02741985 chr17:80059408 CCDC57 0.43 7.15 0.37 5.59e-12 Life satisfaction; CRC trans rs1286150 0.685 rs1286061 chr14:91456994 A/G cg22761205 chr11:457256 PTDSS2 0.37 5.99 0.31 5.61e-9 Total body bone mineral density; CRC cis rs875971 0.660 rs801211 chr7:66015689 T/G cg25985355 chr7:65971099 NA 0.32 5.67 0.3 3.12e-8 Aortic root size; CRC cis rs11785400 1.000 rs4736365 chr8:143742197 A/G cg24634471 chr8:143751801 JRK 0.53 7.55 0.38 4.46e-13 Schizophrenia; CRC cis rs473651 0.904 rs10929275 chr2:239323169 A/G cg18131467 chr2:239335373 ASB1 1.0 22.33 0.78 7.15e-68 Multiple system atrophy; CRC cis rs2404602 0.692 rs72738889 chr15:76992063 G/A cg23625390 chr15:77176239 SCAPER 0.49 7.26 0.37 2.76e-12 Blood metabolite levels; CRC cis rs4843747 0.671 rs28671027 chr16:88116323 G/A cg17633681 chr16:88106987 BANP 0.83 14.52 0.62 2.99e-37 Menopause (age at onset); CRC cis rs1538970 0.924 rs12037201 chr1:45941349 G/T cg05343316 chr1:45956843 TESK2 0.72 9.67 0.47 1.24e-19 Platelet count; CRC cis rs7772486 0.806 rs4075696 chr6:146250947 T/C cg23711669 chr6:146136114 FBXO30 -0.65 -11.1 -0.52 1.62e-24 Lobe attachment (rater-scored or self-reported); CRC cis rs873946 0.504 rs12775990 chr10:134575836 C/T cg27286337 chr10:134555280 INPP5A 0.77 9.91 0.48 2.05e-20 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CRC cis rs1552244 0.688 rs7645137 chr3:10020549 A/AT cg00166722 chr3:10149974 C3orf24 0.63 8.24 0.41 4.1e-15 Alzheimer's disease; CRC cis rs3816788 0.792 rs729180 chr8:21817245 C/T cg16476235 chr8:21771668 DOK2 0.36 6.13 0.32 2.55e-9 Lung cancer in ever smokers; CRC trans rs877282 0.583 rs112372193 chr10:826602 A/G cg22713356 chr15:30763199 NA 0.78 8.84 0.44 5.72e-17 Uric acid levels; CRC cis rs2032447 0.714 rs199739 chr6:25960509 A/C cg12310025 chr6:25882481 NA -0.63 -9.21 -0.45 3.94e-18 Intelligence (multi-trait analysis); CRC cis rs28386778 0.897 rs8069969 chr17:61822223 T/G cg11494091 chr17:61959527 GH2 0.6 10.29 0.49 1.01e-21 Prudent dietary pattern; CRC cis rs35306767 0.855 rs11253499 chr10:944090 A/C cg26597838 chr10:835615 NA 0.97 11.74 0.54 7.83e-27 Eosinophil percentage of granulocytes; CRC cis rs758324 0.947 rs380182 chr5:131319036 A/G cg06307176 chr5:131281290 NA -0.42 -6.33 -0.33 8.23e-10 Alzheimer's disease in APOE e4- carriers; CRC cis rs9910055 0.676 rs11079983 chr17:42198170 C/T cg13607699 chr17:42295918 UBTF 0.51 6.95 0.36 1.94e-11 Total body bone mineral density; CRC cis rs703842 0.892 rs1021469 chr12:58208164 C/T cg00677455 chr12:58241039 CTDSP2 0.63 8.8 0.44 7.71e-17 Multiple sclerosis; CRC cis rs7429990 0.932 rs60446735 chr3:47971448 A/G cg11946769 chr3:48343235 NME6 0.44 5.81 0.31 1.47e-8 Educational attainment (years of education); CRC cis rs2806561 0.780 rs6650086 chr1:23338384 T/C cg19743168 chr1:23544995 NA -0.37 -5.94 -0.31 7.37e-9 Height; CRC cis rs2243480 1.000 rs9769882 chr7:65642925 T/C cg12463550 chr7:65579703 CRCP -0.71 -6.52 -0.34 2.61e-10 Diabetic kidney disease; CRC cis rs7208859 0.623 rs58089675 chr17:29196764 C/G cg13385521 chr17:29058706 SUZ12P 0.69 8.01 0.4 2.02e-14 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs28386778 0.897 rs7207005 chr17:61860355 A/G cg07362569 chr17:61921086 SMARCD2 0.37 5.68 0.3 2.98e-8 Prudent dietary pattern; CRC cis rs2535633 0.631 rs6799185 chr3:53101580 C/T cg05573699 chr3:52720067 GNL3;PBRM1 -0.42 -6.29 -0.33 1e-9 Body mass index; CRC trans rs11581859 0.901 rs9651145 chr1:99376910 A/G cg12183875 chr3:169587454 LRRC31 0.27 6.2 0.32 1.74e-9 Response to cognitive-behavioural therapy in anxiety disorder; CRC trans rs9825823 0.617 rs2083264 chr3:61074229 A/G ch.2.121392984R chr2:121676514 GLI2 0.41 5.96 0.31 6.52e-9 Depressive symptom measurement or major depressive disorder; CRC cis rs1552244 0.832 rs67145301 chr3:10197314 G/A cg08888203 chr3:10149979 C3orf24 0.66 7.7 0.39 1.58e-13 Alzheimer's disease; CRC cis rs9359856 1.000 rs2094487 chr6:90314072 T/A cg13799429 chr6:90582589 CASP8AP2 0.44 6.25 0.33 1.26e-9 Bipolar disorder; CRC cis rs3862030 0.533 rs715440 chr10:104258095 A/T cg11453585 chr10:104263688 ACTR1A;SUFU -0.77 -13.34 -0.59 9.19e-33 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for body mass index; CRC cis rs12188164 0.561 rs2721010 chr5:456915 A/G cg21625146 chr5:486483 SLC9A3 0.37 5.81 0.31 1.44e-8 Cystic fibrosis severity; CRC trans rs7395662 0.777 rs7114291 chr11:48608251 A/G cg21153622 chr11:89784906 NA -0.45 -7.21 -0.37 3.98e-12 HDL cholesterol; CRC cis rs7762018 1.000 rs11961560 chr6:170130121 T/C cg19338460 chr6:170058176 WDR27 -0.67 -7.38 -0.38 1.32e-12 Thiazide-induced adverse metabolic effects in hypertensive patients; CRC cis rs4900538 0.928 rs1190551 chr14:102911508 A/G cg18135206 chr14:102964638 TECPR2 -0.96 -19.3 -0.73 5.02e-56 Mean corpuscular volume;Mean corpuscular hemoglobin; CRC cis rs7617480 0.616 rs9873227 chr3:48773108 G/C cg20833759 chr3:49053208 WDR6;DALRD3 0.75 11.21 0.53 6.22e-25 Subjective well-being (multi-trait analysis);Menarche (age at onset); CRC cis rs644799 0.710 rs522536 chr11:95528714 C/T cg03916912 chr11:95522834 CEP57;FAM76B 0.85 15.75 0.66 4.84e-42 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs2227564 0.597 rs12256103 chr10:75545251 A/G cg16540259 chr10:75572220 NDST2 0.51 7.86 0.4 5.61e-14 Crohn's disease;Inflammatory bowel disease; CRC cis rs9487051 0.872 rs6924815 chr6:109612344 A/G cg01475377 chr6:109611718 NA -0.49 -9.24 -0.45 3.04e-18 Reticulocyte fraction of red cells; CRC cis rs1799949 1.000 rs8176242 chr17:41217874 C/T cg05368731 chr17:41323189 NBR1 0.65 9.54 0.47 3.32e-19 Menopause (age at onset); CRC cis rs2841277 0.770 rs10149193 chr14:105403474 C/T cg15352829 chr14:105391018 PLD4 -0.5 -10.91 -0.52 7.16e-24 Rheumatoid arthritis; CRC cis rs7626444 0.627 rs5021326 chr3:196477628 A/T cg12930392 chr3:196481615 PAK2 0.39 6.9 0.36 2.72e-11 Monocyte count; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg12184541 chr11:3012310 NAP1L4 0.47 6.86 0.35 3.47e-11 Response to antipsychotic treatment; CRC trans rs2303319 0.504 rs62189048 chr2:162613494 G/C cg25193742 chr10:104614220 C10orf32 -0.77 -6.51 -0.34 2.87e-10 Cognitive function; CRC cis rs2303759 0.515 rs2334867 chr19:49788205 C/T cg24324837 chr19:49891574 CCDC155 -0.43 -5.73 -0.3 2.32e-8 Multiple sclerosis; CRC cis rs72781680 1.000 rs72798411 chr2:24184343 A/G cg08917208 chr2:24149416 ATAD2B 1.04 10.13 0.49 3.61e-21 Lymphocyte counts; CRC cis rs7086627 0.515 rs12245180 chr10:82211897 C/G cg09626299 chr10:82213104 TSPAN14 -0.37 -6.23 -0.33 1.39e-9 Post bronchodilator FEV1; CRC cis rs7589728 0.563 rs78168096 chr2:88473575 G/A cg24977027 chr2:88469347 THNSL2 0.62 7.41 0.38 1.08e-12 Plasma clusterin levels; CRC cis rs7103648 1.000 rs10838709 chr11:47447346 C/T cg20307385 chr11:47447363 PSMC3 1.0 18.73 0.72 8.89e-54 Diastolic blood pressure;Systolic blood pressure; CRC trans rs3774749 0.565 rs2624839 chr3:50202231 T/C cg21659725 chr3:3221576 CRBN 0.45 6.75 0.35 6.56e-11 Intelligence (multi-trait analysis); CRC cis rs7671266 0.628 rs11734783 chr4:10240663 C/T cg00071950 chr4:10020882 SLC2A9 0.45 6.04 0.32 4.16e-9 Cardiovascular disease risk factors; CRC cis rs11971779 0.648 rs10085708 chr7:139110954 A/C cg07862535 chr7:139043722 LUC7L2 0.57 7.32 0.37 1.92e-12 Diisocyanate-induced asthma; CRC cis rs7129556 0.859 rs11237215 chr11:77247515 G/A cg12586386 chr11:77299805 AQP11 0.4 5.66 0.3 3.38e-8 Weight loss (gastric bypass surgery); CRC cis rs10242455 0.702 rs3528 chr7:99055940 T/C cg18809830 chr7:99032528 PTCD1 -0.93 -7.32 -0.37 1.87e-12 Blood metabolite levels; CRC cis rs6952808 0.689 rs871924 chr7:2047845 A/G cg18279126 chr7:2041391 MAD1L1 0.44 6.7 0.35 9.13e-11 Bipolar disorder and schizophrenia; CRC cis rs7617773 0.817 rs11928691 chr3:48286765 C/T cg11946769 chr3:48343235 NME6 0.63 8.61 0.43 3.15e-16 Coronary artery disease; CRC cis rs709400 0.663 rs3742458 chr14:103950368 A/G cg12935359 chr14:103987150 CKB -0.51 -8.36 -0.42 1.79e-15 Body mass index; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg17014378 chr9:136025100 RALGDS 0.46 6.01 0.31 4.83e-9 Thyroid stimulating hormone; CRC cis rs12541335 0.590 rs11136002 chr8:22217082 C/T cg18135555 chr8:22132992 PIWIL2 0.42 8.11 0.41 1e-14 Hypertriglyceridemia; CRC trans rs11105468 1.000 rs56391951 chr12:90274621 G/A cg23572944 chr11:60720130 SLC15A3 -0.43 -6.04 -0.32 4.15e-9 Febrile seizures;Febrile seizures (MMR vaccine-related);Febrile seizures (MMR vaccine-unrelated); CRC cis rs9467773 0.596 rs2451750 chr6:26646579 A/T cg09904177 chr6:26538194 HMGN4 0.72 11.39 0.53 1.47e-25 Intelligence (multi-trait analysis); CRC cis rs362272 0.545 rs2236052 chr4:3318413 C/T cg01612440 chr4:3296283 NA -0.4 -5.77 -0.3 1.84e-8 Serum sulfate level; CRC cis rs13217239 0.646 rs7768407 chr6:27016795 G/A cg12292205 chr6:26970375 C6orf41 0.55 9.13 0.45 7.03e-18 Schizophrenia; CRC cis rs763014 0.966 rs4247097 chr16:654224 G/A cg18653534 chr16:772142 FAM173A -0.36 -5.77 -0.3 1.88e-8 Height; CRC cis rs9914988 0.778 rs9907192 chr17:27122426 C/G cg16670446 chr17:27188758 MIR451;MIR144 0.55 8.52 0.43 5.75e-16 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC trans rs116095464 0.558 rs73024831 chr5:257192 A/G cg00938859 chr5:1591904 SDHAP3 0.73 7.89 0.4 4.53e-14 Breast cancer; CRC cis rs9611565 0.921 rs8137373 chr22:41729216 A/G cg06634786 chr22:41940651 POLR3H 0.49 6.45 0.34 3.94e-10 Vitiligo; CRC cis rs951366 0.789 rs823121 chr1:205724302 A/G cg17178900 chr1:205818956 PM20D1 -0.65 -9.51 -0.46 4.28e-19 Menarche (age at onset); CRC cis rs7692995 1.000 rs16896068 chr4:17944840 C/T cg08925142 chr4:18023851 LCORL -0.53 -6.03 -0.32 4.35e-9 Height; CRC cis rs73198271 0.562 rs17154743 chr8:8650787 A/G cg01851573 chr8:8652454 MFHAS1 0.5 6.77 0.35 5.87e-11 Bone ultrasound measurement (broadband ultrasound attenuation); CRC cis rs9733 0.526 rs6587542 chr1:150907701 G/T cg10589385 chr1:150898437 SETDB1 0.27 5.92 0.31 7.89e-9 Tonsillectomy; CRC cis rs7811142 0.830 rs41280971 chr7:99954457 G/T cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.15 16.88 0.68 1.67e-46 Platelet count; CRC cis rs1552244 0.572 rs59132826 chr3:10169725 G/A cg16606324 chr3:10149918 C3orf24 0.66 7.77 0.39 9.99e-14 Alzheimer's disease; CRC trans rs1814175 0.616 rs1851848 chr11:49992254 G/C cg11707556 chr5:10655725 ANKRD33B -0.51 -9.82 -0.48 3.9e-20 Height; CRC cis rs875971 0.862 rs11760844 chr7:65739883 C/G cg18876405 chr7:65276391 NA -0.5 -8.2 -0.41 5.45e-15 Aortic root size; CRC cis rs12908161 1.000 rs4643294 chr15:85250253 C/T cg11189052 chr15:85197271 WDR73 0.62 8.85 0.44 5.51e-17 Schizophrenia; CRC cis rs1577917 0.958 rs12191340 chr6:86521400 C/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.5 -6.63 -0.34 1.34e-10 Response to antipsychotic treatment; CRC cis rs2066819 1.000 rs76745316 chr12:56627652 A/C cg26714650 chr12:56694279 CS -1.43 -11.59 -0.54 2.88e-26 Psoriasis vulgaris; CRC cis rs875971 0.895 rs12531677 chr7:65769086 G/A cg18876405 chr7:65276391 NA -0.53 -8.56 -0.43 4.37e-16 Aortic root size; CRC cis rs6912958 0.712 rs6454638 chr6:88329427 C/T cg08069147 chr6:88032118 GJB7;C6orf162 0.59 8.9 0.44 3.83e-17 Monocyte percentage of white cells; CRC cis rs2976388 1.000 rs2920298 chr8:143763043 A/G cg22687807 chr8:143858763 LYNX1 -0.37 -6.47 -0.34 3.46e-10 Urinary tract infection frequency; CRC cis rs208520 0.690 rs6932475 chr6:66863155 G/A cg07460842 chr6:66804631 NA -1.07 -14.88 -0.63 1.18e-38 Exhaled nitric oxide output; CRC cis rs28655083 1.000 rs11863397 chr16:77060388 T/A cg01753188 chr16:77233325 SYCE1L;MON1B -0.57 -7.9 -0.4 4.24e-14 Lobe attachment (rater-scored or self-reported); CRC cis rs2832191 0.671 rs2832213 chr21:30512914 A/G cg08807101 chr21:30365312 RNF160 -0.52 -7.26 -0.37 2.78e-12 Dental caries; CRC cis rs1552244 0.816 rs56271597 chr3:10042790 C/T cg10729496 chr3:10149963 C3orf24 0.5 6.53 0.34 2.55e-10 Alzheimer's disease; CRC cis rs10504229 0.679 rs72649115 chr8:58037631 T/G cg02290350 chr8:58132656 NA -0.56 -6.4 -0.33 5.27e-10 Developmental language disorder (linguistic errors); CRC cis rs7071206 0.947 rs10824560 chr10:79416901 C/T cg07817648 chr10:79422355 NA -0.74 -9.68 -0.47 1.12e-19 Bone mineral density; CRC cis rs9283706 0.608 rs13171572 chr5:66334552 T/A cg11590213 chr5:66331682 MAST4 0.4 5.62 0.3 4.06e-8 Coronary artery disease; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg06443542 chr10:100206752 HPS1 0.41 6.53 0.34 2.47e-10 Liver disease severity in Alagille syndrome; CRC cis rs597539 0.652 rs569777 chr11:68706848 G/A cg04772025 chr11:68637568 NA 0.47 7.27 0.37 2.7e-12 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs3008870 0.755 rs4655662 chr1:67416432 T/C cg08660285 chr1:67390436 MIER1;WDR78 0.54 7.63 0.39 2.59e-13 Lymphocyte percentage of white cells; CRC cis rs2213920 0.679 rs4979523 chr9:118177550 G/A cg13918206 chr9:118159781 DEC1 0.62 5.88 0.31 1.03e-8 Docetaxel-induced peripheral neuropathy in metastatic castrate-resistant prostate cancer; CRC cis rs11098499 0.820 rs6534140 chr4:120455311 C/T cg09307838 chr4:120376055 NA 0.69 10.34 0.5 6.68e-22 Corneal astigmatism; CRC cis rs1401999 0.932 rs4148557 chr3:183733784 A/G cg01324343 chr3:183735012 ABCC5 0.78 13.87 0.61 9.11e-35 Anterior chamber depth; CRC cis rs1568889 0.838 rs6484347 chr11:28040969 G/T cg06544937 chr11:28130018 METT5D1;KIF18A -0.94 -16.39 -0.67 1.54e-44 Bipolar disorder; CRC cis rs617791 0.508 rs10791837 chr11:65774596 C/T cg09783858 chr11:65769428 EIF1AD;BANF1 0.5 7.61 0.39 2.92e-13 Breast cancer; CRC cis rs7945705 0.747 rs10840158 chr11:9020897 A/C cg21881798 chr11:8931708 C11orf17;ST5 -0.63 -10.58 -0.5 1.03e-22 Hemoglobin concentration; CRC cis rs910316 0.967 rs10142770 chr14:75525449 G/A cg08847533 chr14:75593920 NEK9 0.97 19.05 0.72 4.76e-55 Height; CRC cis rs8060686 0.516 rs4640173 chr16:68163602 C/A cg26727032 chr16:67993705 SLC12A4 -0.57 -8.5 -0.42 6.63e-16 HDL cholesterol;Metabolic syndrome; CRC cis rs2050392 0.517 rs589980 chr10:30756385 T/A cg25182066 chr10:30743637 MAP3K8 -0.61 -8.65 -0.43 2.34e-16 Inflammatory bowel disease; CRC cis rs9381040 0.599 rs2057001 chr6:41022947 A/G cg04346459 chr6:41068666 NFYA;LOC221442 -0.42 -6.35 -0.33 7.09e-10 Alzheimer's disease (late onset); CRC trans rs11250098 0.548 rs7843470 chr8:10784492 C/G cg08071915 chr8:12219732 FAM66A 0.36 6.3 0.33 9.48e-10 Morning vs. evening chronotype; CRC cis rs10504229 0.728 rs72650853 chr8:58151473 G/A cg21724239 chr8:58056113 NA 0.62 8.38 0.42 1.51e-15 Developmental language disorder (linguistic errors); CRC cis rs4662945 0.525 rs28819474 chr2:130264623 T/C cg05903289 chr2:130345205 NA -0.36 -6.97 -0.36 1.79e-11 Response to cytidine analogues (gemcitabine); CRC cis rs4919694 1.000 rs7100592 chr10:104769098 T/G cg04362960 chr10:104952993 NT5C2 1.17 10.93 0.52 6.24e-24 Arsenic metabolism; CRC cis rs10751667 1.000 rs10794357 chr11:973374 T/C cg01483505 chr11:975446 AP2A2 0.39 5.88 0.31 1.02e-8 Alzheimer's disease (late onset); CRC cis rs1065852 0.526 rs11090066 chr22:42398195 A/G cg00645731 chr22:42541494 CYP2D7P1 0.39 6.89 0.36 2.86e-11 Response to serotonin reuptake inhibitors in major depressive disorder (plasma drug and metabolite levels); CRC cis rs57221529 0.766 rs72706606 chr5:558609 T/C cg14541582 chr5:601475 NA -0.33 -6.6 -0.34 1.61e-10 Lung disease severity in cystic fibrosis; CRC cis rs2625529 0.652 rs8030815 chr15:72403001 T/C cg16672083 chr15:72433130 SENP8 0.44 6.73 0.35 7.57e-11 Red blood cell count; CRC cis rs12188164 0.965 rs11739543 chr5:443676 G/A cg16322479 chr5:444228 EXOC3;C5orf55 0.5 8.06 0.41 1.43e-14 Cystic fibrosis severity; CRC cis rs9368481 0.645 rs10456350 chr6:26975581 A/C cg12292205 chr6:26970375 C6orf41 0.68 11.23 0.53 5.4e-25 Autism spectrum disorder or schizophrenia; CRC cis rs2204008 0.806 rs3922574 chr12:38329069 C/T cg26384229 chr12:38710491 ALG10B 0.67 9.37 0.46 1.19e-18 Bladder cancer; CRC cis rs9486715 0.867 rs9486181 chr6:96868132 G/A cg06623918 chr6:96969491 KIAA0776 1.02 20.3 0.75 5.5e-60 Headache; CRC cis rs11229555 0.645 rs11229427 chr11:58180275 A/C cg15696309 chr11:58395628 NA -0.81 -10.45 -0.5 2.9e-22 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; CRC cis rs1046896 1.000 rs9909940 chr17:80689036 C/T cg16060761 chr17:80687452 NA -0.54 -8.2 -0.41 5.57e-15 Glycated hemoglobin levels; CRC cis rs933688 0.536 rs332537 chr5:90794973 C/T cg26981201 chr5:90679533 LOC100129716;ARRDC3 -0.74 -9.24 -0.45 3.22e-18 Smoking behavior; CRC cis rs6502050 0.835 rs8078950 chr17:80122327 T/G cg13198984 chr17:80129470 CCDC57 0.47 8.35 0.42 1.88e-15 Life satisfaction; CRC cis rs9447004 0.584 rs12215671 chr6:74435607 T/C cg03006477 chr6:74432658 CD109 0.38 6.54 0.34 2.4e-10 Blood protein levels;Calcium levels; CRC cis rs9311474 0.581 rs4687626 chr3:52569098 G/A cg07507251 chr3:52567010 NT5DC2 0.49 7.4 0.38 1.15e-12 Electroencephalogram traits; CRC trans rs9951602 0.512 rs1903722 chr18:76646539 G/A cg02800362 chr5:177631904 HNRNPAB 0.69 9.93 0.48 1.72e-20 Obesity-related traits; CRC cis rs10174077 0.687 rs4664491 chr2:152479986 C/T cg06191203 chr2:152266755 RIF1 -0.58 -7.43 -0.38 9.32e-13 Squamous cell lung carcinoma; CRC cis rs67340775 0.541 rs200965 chr6:27866384 G/A cg19041857 chr6:27730383 NA -0.6 -6.39 -0.33 5.66e-10 Lung cancer in ever smokers; CRC cis rs7932354 0.528 rs1060573 chr11:47179829 A/G cg19486271 chr11:47235900 DDB2 -0.44 -6.5 -0.34 2.98e-10 Bone mineral density (hip);Bone mineral density; CRC cis rs62064224 0.714 rs11653974 chr17:30635002 T/C cg25809561 chr17:30822961 MYO1D 0.52 9.52 0.46 3.97e-19 Schizophrenia; CRC cis rs3736485 0.966 rs8031903 chr15:51838161 C/T cg08986416 chr15:51914746 DMXL2 -0.45 -6.62 -0.34 1.43e-10 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs10504229 0.953 rs6990806 chr8:58183113 G/A cg24829409 chr8:58192753 C8orf71 -0.68 -11.34 -0.53 2.27e-25 Developmental language disorder (linguistic errors); CRC cis rs11212617 1.000 rs228591 chr11:108097333 A/G cg01991180 chr11:108092276 ATM;NPAT 0.44 6.5 0.34 2.96e-10 Response to metformin in type 2 diabetes (glycemic); CRC cis rs6570726 0.791 rs9399558 chr6:145911730 T/C cg23711669 chr6:146136114 FBXO30 0.75 12.89 0.58 4.75e-31 Lobe attachment (rater-scored or self-reported); CRC cis rs72781680 0.898 rs72782126 chr2:24039901 A/C cg08917208 chr2:24149416 ATAD2B 0.9 9.13 0.45 6.96e-18 Lymphocyte counts; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg05492845 chr11:64002298 VEGFB 0.42 6.8 0.35 5.08e-11 Liver disease severity in Alagille syndrome; CRC cis rs11758351 0.587 rs10484436 chr6:26237155 C/T cg10723962 chr6:26240782 HIST1H4F -0.4 -6.36 -0.33 6.94e-10 Gout;Renal underexcretion gout; CRC cis rs3790645 1.000 rs1064196 chr1:26887592 C/T cg17456097 chr1:26900765 RPS6KA1 -0.41 -6.2 -0.32 1.7e-9 Glucose homeostasis traits; CRC cis rs1801251 0.964 rs6748027 chr2:233629552 T/C cg25237894 chr2:233734115 C2orf82 0.53 8.56 0.43 4.38e-16 Coronary artery disease; CRC cis rs6684514 1.000 rs12141236 chr1:156302575 A/C cg16558208 chr1:156270281 VHLL 0.56 8.76 0.43 1.06e-16 Mean corpuscular hemoglobin concentration;Glycated hemoglobin levels; CRC trans rs7395662 1.000 rs10838931 chr11:48540973 G/A cg21153622 chr11:89784906 NA -0.48 -7.61 -0.39 2.96e-13 HDL cholesterol; CRC cis rs1008375 1.000 rs6449319 chr4:17640283 T/A cg02297831 chr4:17616191 MED28 0.5 6.62 0.34 1.44e-10 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs7617480 0.610 rs4955420 chr3:49208865 A/G cg18654377 chr3:49208889 KLHDC8B -0.39 -5.96 -0.31 6.33e-9 Subjective well-being (multi-trait analysis);Menarche (age at onset); CRC cis rs9733 0.621 rs932054 chr1:150539867 C/G cg17724175 chr1:150552817 MCL1 -0.51 -8.29 -0.42 2.93e-15 Tonsillectomy; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg26644764 chr7:87849153 SRI 0.36 6.03 0.32 4.51e-9 Liver disease severity in Alagille syndrome; CRC trans rs6956675 0.915 rs1609795 chr7:62650531 T/C cg01314568 chr7:57830625 NA -0.64 -8.98 -0.44 2.16e-17 Obesity-related traits; CRC cis rs9372498 0.505 rs56406560 chr6:118991787 G/A cg24463073 chr6:118973353 C6orf204 0.43 5.88 0.31 9.84e-9 Diastolic blood pressure; CRC cis rs2708977 0.899 rs12992413 chr2:97277489 A/G cg01950434 chr2:97203154 ARID5A 0.48 7.0 0.36 1.48e-11 Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes; CRC cis rs9796 0.558 rs11855102 chr15:41513257 T/C cg18705301 chr15:41695430 NDUFAF1 -0.4 -6.7 -0.35 9e-11 Menopause (age at onset); CRC trans rs10982213 0.830 rs2274163 chr9:117188714 C/T cg11450715 chr2:171627404 NA 0.36 5.98 0.31 5.67e-9 Interleukin-6 levels; CRC cis rs2153535 0.526 rs7748404 chr6:8472500 A/T cg07606381 chr6:8435919 SLC35B3 0.68 10.9 0.51 8.26e-24 Motion sickness; CRC cis rs34311866 0.752 rs11725653 chr4:963397 C/T cg07828340 chr4:882639 GAK 1.11 10.48 0.5 2.28e-22 Parkinson's disease; CRC cis rs7224685 0.501 rs4790171 chr17:4022899 T/C cg09597638 chr17:3907349 NA -0.66 -11.58 -0.54 2.94e-26 Type 2 diabetes; CRC cis rs7113874 0.524 rs6484485 chr11:8620740 A/G cg02811074 chr11:8615871 STK33 0.33 5.88 0.31 9.85e-9 Body mass index in physically active individuals;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs17345786 0.667 rs7622940 chr3:101133155 T/C cg11279151 chr3:101281821 RG9MTD1 -0.68 -9.01 -0.44 1.73e-17 Colonoscopy-negative controls vs population controls; CRC cis rs910316 0.967 rs11159116 chr14:75550584 G/T cg11812906 chr14:75593930 NEK9 0.64 10.38 0.5 5.13e-22 Height; CRC trans rs7615952 0.673 rs3811677 chr3:125648080 G/A cg07211511 chr3:129823064 LOC729375 -1.06 -17.63 -0.7 1.99e-49 Blood pressure (smoking interaction); CRC cis rs6952808 1.000 rs59248873 chr7:1888185 A/G cg20295408 chr7:1910781 MAD1L1 -0.43 -6.13 -0.32 2.56e-9 Bipolar disorder and schizophrenia; CRC cis rs7617480 0.587 rs9311431 chr3:48848787 T/A cg20833759 chr3:49053208 WDR6;DALRD3 0.75 11.36 0.53 1.88e-25 Subjective well-being (multi-trait analysis);Menarche (age at onset); CRC cis rs7618915 0.570 rs13068293 chr3:52672167 C/A cg11645453 chr3:52864694 ITIH4 0.36 6.25 0.33 1.29e-9 Bipolar disorder; CRC cis rs747650 0.504 rs10838641 chr11:47003304 G/A cg19486271 chr11:47235900 DDB2 -0.43 -6.51 -0.34 2.82e-10 Acne (severe); CRC cis rs929354 0.742 rs7784442 chr7:156934475 G/C cg05182265 chr7:156933206 UBE3C -0.76 -14.38 -0.62 1.04e-36 Body mass index; CRC cis rs11958404 0.789 rs72818150 chr5:157484121 A/G cg05962755 chr5:157440814 NA 1.04 13.07 0.58 9.51e-32 IgG glycosylation; CRC cis rs394563 0.591 rs237035 chr6:149710848 C/T cg03678062 chr6:149772716 ZC3H12D -0.37 -6.68 -0.35 1.03e-10 Dupuytren's disease; CRC cis rs13256369 0.802 rs12681326 chr8:8566389 G/A cg06671706 chr8:8559999 CLDN23 0.61 8.88 0.44 4.43e-17 Obesity-related traits; CRC trans rs804280 0.560 rs10503426 chr8:11589383 A/C cg16141378 chr3:129829833 LOC729375 -0.42 -6.23 -0.32 1.4e-9 Myopia (pathological); CRC cis rs28374715 0.578 rs7165914 chr15:41632451 C/T cg18705301 chr15:41695430 NDUFAF1 -1.09 -19.04 -0.72 5.24e-55 Ulcerative colitis; CRC cis rs10463316 0.894 rs6579862 chr5:150761717 T/G cg03212797 chr5:150827313 SLC36A1 -0.48 -7.68 -0.39 1.87e-13 Metabolite levels (Pyroglutamine); CRC cis rs2455601 0.574 rs2568094 chr11:8992218 A/G cg09997546 chr11:8931473 C11orf17;ST5 -0.45 -6.15 -0.32 2.25e-9 Schizophrenia; CRC cis rs116095464 0.558 rs9654453 chr5:299621 T/C cg22496380 chr5:211416 CCDC127 -0.96 -9.27 -0.46 2.53e-18 Breast cancer; CRC cis rs9322193 0.923 rs9767123 chr6:149981459 A/G cg07701084 chr6:150067640 NUP43 0.56 8.29 0.42 2.92e-15 Lung cancer; CRC cis rs2836974 0.526 rs1888488 chr21:40686521 C/T cg11890956 chr21:40555474 PSMG1 -0.8 -12.56 -0.57 7.92e-30 Cognitive function; CRC cis rs2294693 0.945 rs9462668 chr6:41004194 T/C cg14769373 chr6:40998127 UNC5CL -0.44 -5.66 -0.3 3.29e-8 Gastric cancer;Non-cardia gastric cancer; CRC cis rs780096 0.526 rs4803 chr2:27667297 A/G cg17158414 chr2:27665306 KRTCAP3 -0.31 -6.75 -0.35 6.85e-11 Total body bone mineral density; CRC cis rs10754283 0.840 rs6428560 chr1:90102462 A/T cg21401794 chr1:90099060 LRRC8C 0.42 6.04 0.32 4.2e-9 Amyotrophic lateral sclerosis (sporadic); CRC cis rs12142240 0.698 rs17361915 chr1:46847321 C/T cg14993813 chr1:46806288 NSUN4 -0.48 -6.03 -0.32 4.47e-9 Menopause (age at onset); CRC cis rs514406 0.505 rs146750 chr1:53183447 C/G cg25767906 chr1:53392781 SCP2 -0.38 -5.82 -0.31 1.41e-8 Monocyte count; CRC cis rs6500395 1.000 rs7191028 chr16:48626023 T/C cg04672837 chr16:48644449 N4BP1 0.44 6.68 0.35 9.93e-11 Response to tocilizumab in rheumatoid arthritis; CRC cis rs2204008 0.775 rs11182513 chr12:38560252 G/C cg13010199 chr12:38710504 ALG10B 0.46 5.79 0.3 1.69e-8 Bladder cancer; CRC cis rs11212617 0.905 rs672964 chr11:108125471 C/G cg14761454 chr11:108092087 ATM;NPAT 0.39 5.63 0.3 3.84e-8 Response to metformin in type 2 diabetes (glycemic); CRC cis rs9359856 0.564 rs11961752 chr6:90481896 T/C cg13799429 chr6:90582589 CASP8AP2 -0.75 -7.61 -0.39 2.88e-13 Bipolar disorder; CRC cis rs9658691 0.646 rs7909414 chr10:90754744 C/T cg03111039 chr10:90751583 FAS;ACTA2 0.78 5.94 0.31 7.22e-9 Mosquito bite size; CRC cis rs904251 0.686 rs1224128 chr6:37415676 C/A cg25019722 chr6:37503610 NA -0.4 -5.82 -0.31 1.36e-8 Cognitive performance; CRC trans rs916888 0.610 rs199438 chr17:44791643 G/A cg22968622 chr17:43663579 NA 0.89 11.88 0.55 2.61e-27 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs773506 0.576 rs943502 chr9:93920745 G/A cg14446406 chr9:93919335 NA -0.55 -9.54 -0.47 3.22e-19 Type 2 diabetes nephropathy; CRC cis rs10078 0.559 rs2672725 chr5:434981 G/C cg07599136 chr5:415885 AHRR 0.64 6.68 0.35 9.95e-11 Fat distribution (HIV); CRC cis rs2243480 1.000 rs313820 chr7:65574466 A/C cg12463550 chr7:65579703 CRCP 0.66 6.15 0.32 2.28e-9 Diabetic kidney disease; CRC cis rs9611565 0.570 rs12159188 chr22:42121125 A/T cg06634786 chr22:41940651 POLR3H 0.48 6.18 0.32 1.92e-9 Vitiligo; CRC trans rs2727020 0.523 rs4115783 chr11:49556026 G/A cg11707556 chr5:10655725 ANKRD33B 0.48 7.85 0.4 6.09e-14 Coronary artery disease; CRC cis rs9462027 0.583 rs9462022 chr6:34761684 A/G cg07306190 chr6:34760872 UHRF1BP1 -0.35 -6.24 -0.33 1.31e-9 Systemic lupus erythematosus; CRC cis rs2836974 0.644 rs2836981 chr21:40688365 C/T cg06238570 chr21:40685208 BRWD1 -0.83 -13.36 -0.59 8.09e-33 Cognitive function; CRC cis rs7647973 0.925 rs4955439 chr3:49245645 G/T cg20833759 chr3:49053208 WDR6;DALRD3 -0.56 -8.41 -0.42 1.27e-15 Menarche (age at onset); CRC cis rs2019137 0.560 rs4849179 chr2:113985170 C/T cg17445212 chr2:113993313 PAX8;LOC440839;LOC654433 0.47 7.24 0.37 3.23e-12 Lymphocyte counts; CRC cis rs9488822 0.676 rs12202641 chr6:116314634 A/G cg18764771 chr6:116381957 FRK -0.24 -6.9 -0.36 2.69e-11 Cholesterol, total;LDL cholesterol; CRC cis rs9660992 0.548 rs1172152 chr1:205220718 T/A cg21643547 chr1:205240462 TMCC2 -0.41 -6.61 -0.34 1.59e-10 Mean corpuscular volume;Mean platelet volume; CRC cis rs56114371 0.777 rs200483 chr6:27774824 C/T cg03623178 chr6:28175578 NA 0.77 6.6 0.34 1.66e-10 Breast cancer; CRC trans rs7267979 1.000 rs6083862 chr20:25411086 A/T cg17903999 chr18:56338584 MALT1 0.4 6.87 0.35 3.21e-11 Liver enzyme levels (alkaline phosphatase); CRC cis rs9322193 0.926 rs9285525 chr6:150122389 C/G cg00933542 chr6:150070202 PCMT1 0.28 5.63 0.3 3.86e-8 Lung cancer; CRC cis rs7072216 0.687 rs10883085 chr10:100155613 A/T cg26618903 chr10:100175079 PYROXD2 -0.35 -5.78 -0.3 1.73e-8 Metabolite levels; CRC cis rs9943753 0.508 rs7138357 chr12:109832303 A/G cg19025524 chr12:109796872 NA -0.53 -8.05 -0.41 1.56e-14 HDL cholesterol; CRC cis rs7786877 0.723 rs10487157 chr7:100214487 C/G cg16850897 chr7:100343110 ZAN -0.54 -6.84 -0.35 3.81e-11 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs7259376 0.837 rs10420149 chr19:22582925 T/G cg02657401 chr19:22469223 NA 0.31 6.6 0.34 1.64e-10 Menopause (age at onset); CRC cis rs6088813 1.000 rs6142359 chr20:33960450 T/C cg14752227 chr20:34000481 UQCC -0.36 -5.62 -0.3 3.99e-8 Height; CRC cis rs10883723 0.810 rs10748823 chr10:104274465 C/G cg22532475 chr10:104410764 TRIM8 -0.36 -6.79 -0.35 5.39e-11 Allergic disease (asthma, hay fever or eczema); CRC cis rs4319547 1.000 rs10998 chr12:122989412 G/A cg05707623 chr12:122985044 ZCCHC8 -0.79 -9.72 -0.47 8.72e-20 Body mass index; CRC trans rs7647973 0.593 rs28535523 chr3:49848414 C/T cg21665057 chr3:196295764 WDR53;FBXO45 0.64 7.06 0.36 9.93e-12 Menarche (age at onset); CRC cis rs12900413 0.562 rs11631438 chr15:90300620 C/T cg24249390 chr15:90295951 MESP1 -0.62 -9.36 -0.46 1.28e-18 Coronary artery aneurysm in Kawasaki disease; CRC cis rs1799949 1.000 rs12936831 chr17:41331816 C/T cg23758822 chr17:41437982 NA 0.82 13.92 0.61 5.82e-35 Menopause (age at onset); CRC cis rs2836974 0.829 rs34227163 chr21:40551943 A/G cg11644478 chr21:40555479 PSMG1 0.83 12.65 0.57 3.68e-30 Cognitive function; CRC cis rs9287719 0.649 rs10803725 chr2:10732346 T/C cg00105475 chr2:10696890 NA 0.44 7.0 0.36 1.43e-11 Prostate cancer; CRC trans rs8005150 0.737 rs7156702 chr14:88481017 T/C cg25527770 chr19:1444892 NA -0.58 -6.24 -0.33 1.32e-9 Hepatitis B; CRC cis rs11758351 0.660 rs16891455 chr6:26230485 G/A cg22723502 chr6:26240528 HIST1H4F -0.36 -5.83 -0.31 1.33e-8 Gout;Renal underexcretion gout; CRC cis rs9309473 0.898 rs7580750 chr2:73788126 A/G cg20560298 chr2:73613845 ALMS1 -0.46 -5.68 -0.3 2.98e-8 Metabolite levels; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg24138021 chr14:39644158 PNN 0.47 6.53 0.34 2.49e-10 Response to antipsychotic treatment; CRC cis rs2832191 0.550 rs66484040 chr21:30511691 G/A cg08807101 chr21:30365312 RNF160 -0.52 -7.24 -0.37 3.16e-12 Dental caries; CRC cis rs2223471 0.776 rs10948570 chr6:50646175 C/T cg03432817 chr6:50765336 NA -0.41 -6.4 -0.33 5.41e-10 Subcutaneous adipose tissue; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg18466108 chr12:99038412 APAF1;IKBIP -0.4 -6.0 -0.31 5.18e-9 Myopia (pathological); CRC cis rs12476592 0.602 rs2121353 chr2:63899330 C/T cg10828910 chr2:63850056 LOC388955 0.51 6.49 0.34 3.11e-10 Childhood ear infection; CRC cis rs4713118 0.696 rs2394002 chr6:27748015 G/A cg21251018 chr6:28226885 NKAPL 0.43 6.09 0.32 3.1e-9 Parkinson's disease; CRC cis rs4253772 0.550 rs6007761 chr22:46670394 C/T cg24881330 chr22:46731750 TRMU -0.59 -6.99 -0.36 1.5e-11 LDL cholesterol;Cholesterol, total; CRC cis rs6684514 1.000 rs12022194 chr1:156312331 T/A cg16558208 chr1:156270281 VHLL 0.56 8.78 0.44 9.36e-17 Mean corpuscular hemoglobin concentration;Glycated hemoglobin levels; CRC cis rs1552244 0.872 rs6803517 chr3:10065426 C/T cg13047869 chr3:10149882 C3orf24 0.51 7.07 0.36 9.31e-12 Alzheimer's disease; CRC cis rs9911578 0.967 rs2333410 chr17:57137129 G/A cg05425664 chr17:57184151 TRIM37 0.47 7.3 0.37 2.22e-12 Intelligence (multi-trait analysis); CRC cis rs1005277 0.505 rs200937 chr10:38135772 T/C cg25517755 chr10:38738941 LOC399744 -0.45 -6.62 -0.34 1.47e-10 Extrinsic epigenetic age acceleration; CRC trans rs617791 0.508 rs10791837 chr11:65774596 C/T cg17712092 chr4:129076599 LARP1B -0.47 -6.81 -0.35 4.65e-11 Breast cancer; CRC cis rs7512552 0.773 rs3737240 chr1:150483355 C/T cg15654264 chr1:150340011 RPRD2 0.59 8.04 0.41 1.59e-14 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); CRC cis rs7208859 0.623 rs6505207 chr17:29076571 T/C cg13385521 chr17:29058706 SUZ12P 0.72 8.17 0.41 6.77e-15 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs4555082 0.957 rs2975216 chr14:105713134 T/C cg18132624 chr14:105716052 BTBD6;BRF1 -0.42 -7.08 -0.36 8.79e-12 Mean platelet volume;Platelet distribution width; CRC trans rs9858213 1 rs9858213 chr3:49731861 G/T cg21659725 chr3:3221576 CRBN -0.69 -8.97 -0.44 2.31e-17 Educational attainment; CRC cis rs4819052 0.851 rs2838856 chr21:46680766 T/G cg19498844 chr21:46707878 POFUT2;LOC642852 0.7 10.12 0.49 3.77e-21 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs2440129 0.611 rs1126667 chr17:6902760 C/T cg12262378 chr17:6899522 ALOX12 -0.55 -10.49 -0.5 2.05e-22 Tonsillectomy; CRC cis rs9747201 0.963 rs11077982 chr17:80147377 G/C cg14673194 chr17:80132900 CCDC57 -0.5 -6.59 -0.34 1.7e-10 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs6952808 0.756 rs4719311 chr7:1881813 C/T cg22963979 chr7:1858916 MAD1L1 -0.59 -9.5 -0.46 4.34e-19 Bipolar disorder and schizophrenia; CRC cis rs9287719 0.649 rs9973374 chr2:10716384 C/T cg00105475 chr2:10696890 NA 0.45 7.05 0.36 1.05e-11 Prostate cancer; CRC cis rs4713118 0.662 rs149947 chr6:27972433 A/T cg21251018 chr6:28226885 NKAPL 0.45 6.64 0.34 1.3100000000000001e-10 Parkinson's disease; CRC cis rs12188164 0.620 rs1043356 chr5:480948 C/T cg26850624 chr5:429559 AHRR 0.71 9.59 0.47 2.29e-19 Cystic fibrosis severity; CRC cis rs6429082 0.608 rs4659838 chr1:235565315 A/G cg26050004 chr1:235667680 B3GALNT2 -0.44 -5.79 -0.3 1.64e-8 Adiposity; CRC cis rs12325245 0.536 rs17821543 chr16:58540875 C/T cg19824325 chr16:58548873 SETD6 0.97 6.51 0.34 2.83e-10 Schizophrenia; CRC cis rs13108904 0.901 rs13112706 chr4:1303682 G/T cg02018176 chr4:1364513 KIAA1530 0.46 7.47 0.38 7.22e-13 Obesity-related traits; CRC cis rs853679 0.517 rs55747925 chr6:28044337 T/C cg02683197 chr6:28174875 NA 0.79 9.73 0.47 8.12e-20 Depression; CRC trans rs2014572 0.933 rs8107516 chr19:57758445 A/G cg02674126 chr19:40336878 FBL 0.42 6.68 0.35 1.04e-10 Hyperactive-impulsive symptoms; CRC cis rs25422 0.887 rs9320666 chr6:118989181 C/T cg10217327 chr6:118973057 C6orf204 0.46 5.73 0.3 2.32e-8 Renal cell carcinoma; CRC cis rs13108904 0.870 rs4493483 chr4:1279916 G/A cg16405210 chr4:1374714 KIAA1530 -0.44 -5.94 -0.31 7.23e-9 Obesity-related traits; CRC cis rs832540 0.898 rs2662024 chr5:56257515 T/C cg12311346 chr5:56204834 C5orf35 0.48 7.52 0.38 5.2e-13 Coronary artery disease; CRC cis rs9292777 0.720 rs9292769 chr5:40397911 A/G cg09067459 chr5:40385259 NA 0.52 8.82 0.44 7.07e-17 Crohn's disease;Multiple sclerosis; CRC cis rs941408 0.515 rs759067 chr19:2775668 C/T cg17333051 chr19:2783644 SGTA 0.47 6.89 0.36 2.87e-11 Total cholesterol levels; CRC cis rs12479064 0.724 rs3792150 chr2:100041849 G/A cg14399236 chr2:99771627 LIPT1;TSGA10 -0.64 -8.13 -0.41 8.77e-15 Chronic sinus infection; CRC cis rs7927592 0.913 rs66752716 chr11:68273626 C/T cg16797656 chr11:68205561 LRP5 0.37 5.84 0.31 1.27e-8 Total body bone mineral density; CRC cis rs10504229 0.683 rs2291765 chr8:58142874 C/T cg04204079 chr8:58130323 NA -0.45 -6.09 -0.32 3.17e-9 Developmental language disorder (linguistic errors); CRC cis rs2180341 0.781 rs7760652 chr6:127572096 A/G cg24812749 chr6:127587940 RNF146 0.74 10.9 0.51 8.27e-24 Breast cancer; CRC cis rs8072100 0.875 rs7208530 chr17:45544107 C/T cg08085267 chr17:45401833 C17orf57 -0.6 -9.46 -0.46 6.22e-19 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs9611565 0.512 rs5758450 chr22:42141640 G/A cg06481639 chr22:41940642 POLR3H 0.55 6.17 0.32 1.98e-9 Vitiligo; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg00746693 chr19:34746153 KIAA0355 0.4 6.63 0.34 1.38e-10 Liver disease severity in Alagille syndrome; CRC cis rs760805 1.000 rs3845302 chr1:25259884 C/G cg22509179 chr1:25234806 RUNX3 -0.57 -9.02 -0.45 1.58e-17 Allergic disease (asthma, hay fever or eczema); CRC cis rs4654899 0.865 rs12130664 chr1:21332812 G/T cg05370193 chr1:21551575 ECE1 0.36 5.68 0.3 2.99e-8 Superior frontal gyrus grey matter volume; CRC cis rs1218582 0.741 rs10908447 chr1:154869742 C/T cg03351412 chr1:154909251 PMVK 0.53 7.82 0.4 7.13e-14 Prostate cancer; CRC cis rs2836974 0.897 rs34599551 chr21:40594898 C/A cg11644478 chr21:40555479 PSMG1 0.82 13.02 0.58 1.52e-31 Cognitive function; CRC cis rs4713118 0.513 rs149878 chr6:27878738 T/G cg26587870 chr6:27730563 NA -0.41 -6.41 -0.33 4.99e-10 Parkinson's disease; CRC cis rs7680126 0.633 rs4697745 chr4:10305081 G/A cg11266682 chr4:10021025 SLC2A9 -0.44 -6.83 -0.35 4.11e-11 Urate levels in lean individuals;Urate levels in overweight individuals;Urate levels in obese individuals; CRC cis rs9372498 0.536 rs9481821 chr6:118846022 A/C cg10217327 chr6:118973057 C6orf204 0.49 5.63 0.3 3.81e-8 Diastolic blood pressure; CRC cis rs4665809 0.590 rs34728554 chr2:26481959 C/G cg27170947 chr2:26402098 FAM59B 0.6 7.82 0.4 7.45e-14 Gut microbiome composition (summer); CRC cis rs1451375 0.698 rs11489734 chr7:50635730 A/T cg18232548 chr7:50535776 DDC 0.42 6.09 0.32 3.14e-9 Malaria; CRC cis rs6940638 0.615 rs9393801 chr6:27242681 A/G cg12292205 chr6:26970375 C6orf41 -0.52 -7.46 -0.38 7.73e-13 Intelligence (multi-trait analysis); CRC cis rs9399135 0.967 rs7773126 chr6:135318390 A/G cg22676075 chr6:135203613 NA 0.42 6.33 0.33 8.1e-10 Red blood cell count; CRC cis rs4253772 0.515 rs6008591 chr22:46703664 T/C cg03482458 chr22:46692211 CN5H6.4;GTSE1 0.5 6.2 0.32 1.65e-9 LDL cholesterol;Cholesterol, total; CRC cis rs2282802 0.711 rs3777095 chr5:139660916 G/A cg26211634 chr5:139558579 C5orf32 0.41 7.01 0.36 1.37e-11 Intelligence (multi-trait analysis); CRC cis rs17376456 0.825 rs10056879 chr5:93282218 C/A cg09848695 chr5:92956644 FAM172A;MIR2277 0.68 5.73 0.3 2.23e-8 Diabetic retinopathy; CRC cis rs7224685 0.501 rs6502765 chr17:3901814 A/G cg11204139 chr17:3907470 NA 0.82 16.33 0.67 2.53e-44 Type 2 diabetes; CRC cis rs10924970 0.967 rs2382616 chr1:235454237 C/T cg26050004 chr1:235667680 B3GALNT2 0.39 5.89 0.31 9.32e-9 Asthma; CRC cis rs2576037 0.526 rs4890699 chr18:44541029 T/C cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.66 -10.37 -0.5 5.54e-22 Personality dimensions; CRC cis rs35110281 0.563 rs162371 chr21:44931489 G/T cg01579765 chr21:45077557 HSF2BP -0.36 -6.67 -0.34 1.1e-10 Mean corpuscular volume; CRC cis rs9549328 0.800 rs9549326 chr13:113630453 C/T cg20742385 chr13:113633654 MCF2L -0.71 -12.53 -0.57 1.05e-29 Systolic blood pressure; CRC cis rs6952808 0.929 rs12532128 chr7:1925454 T/C cg02951883 chr7:2050386 MAD1L1 -0.72 -11.73 -0.54 8.71e-27 Bipolar disorder and schizophrenia; CRC cis rs77861329 1.000 rs9815010 chr3:52196548 C/T cg08692210 chr3:52188851 WDR51A 0.86 8.07 0.41 1.3e-14 Macrophage inflammatory protein 1b levels; CRC cis rs9916302 0.706 rs28482878 chr17:37497100 A/G cg15445000 chr17:37608096 MED1 -0.35 -6.09 -0.32 3.18e-9 Glomerular filtration rate (creatinine); CRC trans rs916888 0.610 rs199442 chr17:44820122 G/A cg22433210 chr17:43662623 NA 0.63 7.72 0.39 1.45e-13 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs6912958 0.703 rs6903219 chr6:88096498 G/A cg12350822 chr6:88032061 C6orf162;GJB7 0.47 9.42 0.46 8.42e-19 Monocyte percentage of white cells; CRC cis rs6952808 1.000 rs12699404 chr7:1894022 A/T cg22963979 chr7:1858916 MAD1L1 -0.69 -10.48 -0.5 2.36e-22 Bipolar disorder and schizophrenia; CRC cis rs11997175 0.574 rs4370495 chr8:33654819 G/A cg04338863 chr8:33670619 NA 0.39 6.84 0.35 3.92e-11 Body mass index; CRC trans rs1005277 0.579 rs2474608 chr10:38457109 C/T cg23533926 chr12:111358616 MYL2 -0.5 -7.56 -0.38 4.1e-13 Extrinsic epigenetic age acceleration; CRC cis rs9372498 0.505 rs9320655 chr6:118830981 T/C cg24463073 chr6:118973353 C6orf204 0.52 6.99 0.36 1.51e-11 Diastolic blood pressure; CRC cis rs2836974 0.899 rs8127087 chr21:40544502 C/T cg06238570 chr21:40685208 BRWD1 0.76 10.62 0.51 7.3e-23 Cognitive function; CRC cis rs6662572 0.737 rs12045409 chr1:46358720 C/T cg08644498 chr1:46502608 NA 0.43 6.4 0.33 5.47e-10 Blood protein levels; CRC trans rs1005277 0.691 rs2474558 chr10:38486141 A/C cg11292332 chr7:45801988 SEPT13 0.37 6.34 0.33 7.7e-10 Extrinsic epigenetic age acceleration; CRC cis rs35883536 1.000 rs12409831 chr1:101107670 A/T cg14515779 chr1:101123966 NA -0.43 -8.3 -0.42 2.75e-15 Monocyte count; CRC cis rs9900062 0.586 rs2676307 chr17:62690713 C/G cg02097616 chr17:62675921 NA 0.5 6.81 0.35 4.77e-11 QT interval; CRC cis rs9894429 0.700 rs113915083 chr17:79552696 G/C cg21984481 chr17:79567631 NPLOC4 0.57 10.59 0.5 9.49e-23 Eye color traits; CRC cis rs11628318 0.614 rs1190335 chr14:103111358 T/C cg12046867 chr14:103022105 NA -0.42 -6.1 -0.32 2.94e-9 Platelet count; CRC trans rs2303319 0.504 rs62187612 chr2:162432494 A/G cg20397358 chr22:38597902 MAFF -0.73 -6.01 -0.31 4.9e-9 Cognitive function; CRC cis rs17711722 0.727 rs2658585 chr7:65461941 A/T cg11764359 chr7:65958608 NA 0.51 7.81 0.4 7.87e-14 Calcium levels; CRC cis rs1552244 0.882 rs13064570 chr3:9997545 G/C cg00166722 chr3:10149974 C3orf24 0.61 8.09 0.41 1.19e-14 Alzheimer's disease; CRC cis rs7927771 0.832 rs11601173 chr11:47401058 A/G cg05585544 chr11:47624801 NA -0.5 -8.98 -0.44 2.06e-17 Subjective well-being; CRC cis rs35306767 0.903 rs17159950 chr10:875287 T/G cg20503657 chr10:835505 NA 0.94 11.39 0.53 1.51e-25 Eosinophil percentage of granulocytes; CRC cis rs10504229 0.636 rs77753517 chr8:58115897 C/T cg02290350 chr8:58132656 NA -0.58 -8.16 -0.41 7.29e-15 Developmental language disorder (linguistic errors); CRC trans rs34156428 0.527 rs78181642 chr11:16807417 C/T cg05563613 chr7:99070410 ZNF789 0.72 6.0 0.31 5.15e-9 Coronary artery disease; CRC trans rs61931739 0.500 rs7484658 chr12:34515879 A/G cg13010199 chr12:38710504 ALG10B 0.45 6.47 0.34 3.5e-10 Morning vs. evening chronotype; CRC cis rs6089584 0.888 rs2892060 chr20:60617955 G/T cg23262073 chr20:60523788 NA -0.46 -7.24 -0.37 3.25e-12 Body mass index; CRC cis rs12477438 0.798 rs6740267 chr2:99561867 T/C cg26064155 chr2:99771622 LIPT1;TSGA10 -0.74 -10.39 -0.5 4.73e-22 Chronic sinus infection; CRC cis rs9650657 0.506 rs7823296 chr8:10778546 A/G cg27411982 chr8:10470053 RP1L1 -0.42 -6.44 -0.33 4.31e-10 Neuroticism; CRC cis rs12701220 0.655 rs34344742 chr7:1149288 C/G cg02733842 chr7:1102375 C7orf50 -0.67 -8.19 -0.41 5.93e-15 Bronchopulmonary dysplasia; CRC cis rs58688157 0.883 rs7936397 chr11:577534 G/A cg16486109 chr11:613632 IRF7 0.64 11.33 0.53 2.37e-25 Systemic lupus erythematosus; CRC cis rs1223397 0.589 rs364493 chr6:13297020 C/T cg21538684 chr6:13274180 PHACTR1 -0.4 -5.93 -0.31 7.62e-9 Blood pressure; CRC cis rs10078 0.559 rs2671891 chr5:456386 A/G cg07599136 chr5:415885 AHRR 0.71 7.04 0.36 1.09e-11 Fat distribution (HIV); CRC cis rs6545883 0.931 rs9807965 chr2:61732159 T/C cg15711740 chr2:61764176 XPO1 -0.52 -7.23 -0.37 3.34e-12 Tuberculosis; CRC cis rs7647973 0.769 rs11130181 chr3:49109919 G/A cg20833759 chr3:49053208 WDR6;DALRD3 0.65 10.56 0.5 1.18e-22 Menarche (age at onset); CRC cis rs9811920 0.695 rs793497 chr3:99505610 T/C cg07805332 chr3:99536008 MIR548G;C3orf26 0.38 5.76 0.3 1.93e-8 Axial length; CRC cis rs9329289 0.510 rs12359941 chr10:2547015 G/A cg15501526 chr10:2543763 NA 0.53 9.89 0.48 2.34e-20 Age-related hearing impairment; CRC cis rs2976388 0.590 rs13254346 chr8:143823863 G/C cg24634471 chr8:143751801 JRK -0.45 -6.41 -0.33 5.18e-10 Urinary tract infection frequency; CRC cis rs9534288 0.912 rs4942468 chr13:46618290 C/A cg15192986 chr13:46630673 CPB2 -0.72 -10.13 -0.49 3.64e-21 Blood protein levels; CRC cis rs6460942 1.000 rs112996286 chr7:12315741 G/C cg06484146 chr7:12443880 VWDE -0.76 -7.52 -0.38 5.36e-13 Coronary artery disease; CRC cis rs9916302 0.904 rs4795357 chr17:37569551 T/C cg07936489 chr17:37558343 FBXL20 -0.83 -12.53 -0.57 1.06e-29 Glomerular filtration rate (creatinine); CRC cis rs3785574 0.927 rs2008018 chr17:61954471 C/T cg23090583 chr17:61904693 PSMC5;FTSJ3 0.56 8.1 0.41 1.06e-14 Height; CRC cis rs10991814 0.920 rs7856668 chr9:94040209 C/A cg14446406 chr9:93919335 NA 0.58 6.42 0.33 4.67e-10 Neutrophil percentage of granulocytes; CRC cis rs6484504 0.576 rs208088 chr11:31192686 T/C cg14844989 chr11:31128820 NA -0.34 -5.9 -0.31 8.8e-9 Red blood cell count; CRC cis rs1552172 0.922 rs12755149 chr1:145704918 T/A cg11743829 chr1:145714124 CD160 -0.41 -6.1 -0.32 2.94e-9 Breast cancer; CRC cis rs9303280 0.806 rs36038753 chr17:38035370 G/T cg11212589 chr17:38028394 ZPBP2 0.43 8.03 0.4 1.71e-14 Self-reported allergy; CRC cis rs10221833 0.602 rs355883 chr2:165633925 A/T cg03182029 chr2:165697222 COBLL1 0.5 5.83 0.31 1.35e-8 Response to statin therapy; CRC cis rs6952808 0.792 rs11771973 chr7:1950440 C/G cg02951883 chr7:2050386 MAD1L1 -0.69 -10.86 -0.51 1.06e-23 Bipolar disorder and schizophrenia; CRC cis rs11098499 0.908 rs7695996 chr4:120322033 C/T cg09307838 chr4:120376055 NA 0.71 11.02 0.52 3.13e-24 Corneal astigmatism; CRC cis rs1799949 0.965 rs8176087 chr17:41270666 C/A cg23758822 chr17:41437982 NA 0.8 13.37 0.59 7.61e-33 Menopause (age at onset); CRC cis rs853679 0.513 rs9468296 chr6:28113730 A/G cg25164649 chr6:28176230 NA 0.78 9.66 0.47 1.33e-19 Depression; CRC trans rs8141529 0.507 rs5762936 chr22:29381377 A/G cg18519450 chr2:121746027 GLI2 0.52 6.24 0.33 1.33e-9 Lymphocyte counts; CRC cis rs1448094 0.549 rs10863085 chr12:86236328 G/A cg25456477 chr12:86230367 RASSF9 0.36 6.23 0.32 1.46e-9 Major depressive disorder; CRC cis rs7677751 0.806 rs6850748 chr4:55099164 T/G cg00691999 chr4:55094011 PDGFRA 0.41 5.76 0.3 1.89e-8 Corneal astigmatism; CRC cis rs6860806 0.507 rs273917 chr5:131659618 A/G cg12564285 chr5:131593104 PDLIM4 0.46 7.68 0.39 1.89e-13 Breast cancer; CRC cis rs6840360 0.582 rs4696260 chr4:152318924 T/C cg09659197 chr4:152720779 NA 0.3 5.66 0.3 3.28e-8 Intelligence (multi-trait analysis); CRC cis rs2933343 0.729 rs1680781 chr3:128612830 C/A cg11901034 chr3:128598214 ACAD9 -0.55 -7.76 -0.39 1.06e-13 IgG glycosylation; CRC trans rs2303319 0.504 rs79046651 chr2:162326417 C/A cg19471553 chr17:41393123 NA -0.7 -6.07 -0.32 3.48e-9 Cognitive function; CRC cis rs13064411 0.696 rs1486894 chr3:113211513 G/A cg18753928 chr3:113234510 CCDC52 -0.7 -10.83 -0.51 1.45e-23 Response to simvastatin treatment (PCSK9 protein level change); CRC cis rs763121 0.853 rs2413546 chr22:39107001 G/A cg06544989 chr22:39130855 UNC84B 0.45 6.84 0.35 3.88e-11 Menopause (age at onset); CRC cis rs62229266 0.659 rs2026259 chr21:37430627 A/G cg08632701 chr21:37451849 NA -0.44 -7.03 -0.36 1.22e-11 Mitral valve prolapse; CRC cis rs875971 0.522 rs7784623 chr7:65395034 T/G cg11764359 chr7:65958608 NA 0.5 7.7 0.39 1.6e-13 Aortic root size; CRC cis rs9443645 0.901 rs2174743 chr6:79591805 G/A cg09184832 chr6:79620586 NA -0.52 -9.73 -0.47 7.97e-20 Intelligence (multi-trait analysis); CRC cis rs9911578 1.000 rs2643119 chr17:56827760 G/T cg12560992 chr17:57184187 TRIM37 0.9 16.62 0.68 1.87e-45 Intelligence (multi-trait analysis); CRC cis rs7666738 0.830 rs113999196 chr4:99041961 C/T cg05340658 chr4:99064831 C4orf37 0.6 9.35 0.46 1.36e-18 Colonoscopy-negative controls vs population controls; CRC trans rs2303319 0.504 rs62189052 chr2:162623869 C/G cg22988483 chr14:93581567 ITPK1 -0.66 -6.08 -0.32 3.32e-9 Cognitive function; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg00734800 chr3:50388182 TUSC4;CYB561D2 0.49 6.37 0.33 6.3e-10 Thyroid stimulating hormone; CRC cis rs11098499 0.710 rs4145952 chr4:120155806 C/A cg24375607 chr4:120327624 NA 0.4 6.46 0.34 3.72e-10 Corneal astigmatism; CRC cis rs7927771 0.524 rs10742817 chr11:47689343 A/G cg20307385 chr11:47447363 PSMC3 -0.48 -7.22 -0.37 3.71e-12 Subjective well-being; CRC cis rs6066835 0.867 rs8123336 chr20:47361725 C/T cg18078177 chr20:47281410 PREX1 -0.64 -5.67 -0.3 3.06e-8 Multiple myeloma; CRC cis rs1904096 0.506 rs8336 chr4:95211610 A/G cg11021082 chr4:95130006 SMARCAD1 -0.56 -8.9 -0.44 3.78e-17 Type 2 diabetes; CRC cis rs875971 1.000 rs6961717 chr7:65587537 C/T cg18876405 chr7:65276391 NA -0.52 -8.94 -0.44 2.91e-17 Aortic root size; CRC cis rs2396545 0.638 rs1062099 chr11:567627 G/C cg07212818 chr11:638076 DRD4 -0.45 -5.64 -0.3 3.65e-8 Systemic lupus erythematosus and Systemic sclerosis; CRC cis rs35110281 0.548 rs7276316 chr21:45029333 A/T cg04455712 chr21:45112962 RRP1B 0.42 8.09 0.41 1.16e-14 Mean corpuscular volume; CRC cis rs72627123 0.867 rs73303129 chr14:74489244 A/T cg12022184 chr14:74485813 ENTPD5;C14orf45 0.72 6.19 0.32 1.8e-9 Morning vs. evening chronotype; CRC cis rs17401966 0.931 rs2276100 chr1:10394536 C/G cg19773385 chr1:10388646 KIF1B -0.7 -11.41 -0.53 1.25e-25 Hepatocellular carcinoma; CRC cis rs3749237 0.595 rs1464567 chr3:49459252 C/G cg03060546 chr3:49711283 APEH -0.66 -11.44 -0.53 9.33e-26 Resting heart rate; CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg00243897 chr12:122326549 PSMD9 0.38 6.05 0.32 4e-9 Obesity-related traits; CRC trans rs9650657 0.504 rs7813802 chr8:11033976 C/T cg06636001 chr8:8085503 FLJ10661 0.54 8.3 0.42 2.7e-15 Neuroticism; CRC cis rs2228479 0.850 rs17226498 chr16:89840631 T/C cg06558623 chr16:89946397 TCF25 1.09 10.23 0.49 1.69e-21 Skin colour saturation; CRC cis rs4688759 0.609 rs113176147 chr3:49534439 G/T cg01304814 chr3:48885189 PRKAR2A 0.83 6.05 0.32 3.92e-9 Blood protein levels; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg05975219 chr16:90088916 GAS8 0.44 6.6 0.34 1.67e-10 Intelligence (multi-trait analysis); CRC cis rs7552404 0.883 rs7513363 chr1:76143443 A/G cg03433033 chr1:76189801 ACADM 0.92 14.11 0.61 1.14e-35 Blood metabolite levels;Acylcarnitine levels; CRC cis rs4974559 0.501 rs2101094 chr4:1235643 A/G cg02980000 chr4:1222292 CTBP1 -0.87 -9.96 -0.48 1.32e-20 Systolic blood pressure; CRC cis rs6087990 0.806 rs4911257 chr20:31359574 T/C cg13636640 chr20:31349939 DNMT3B 0.73 14.14 0.61 8.53e-36 Ulcerative colitis; CRC cis rs10540 0.558 rs12806062 chr11:501429 G/A cg03576123 chr11:487126 PTDSS2 -1.11 -11.15 -0.52 1.08e-24 Body mass index; CRC cis rs72945132 0.825 rs57871058 chr11:70192344 T/C cg00319359 chr11:70116639 PPFIA1 0.58 6.28 0.33 1.09e-9 Coronary artery disease; CRC cis rs6694270 0.529 rs12565650 chr1:19108355 G/A cg19637330 chr1:19110922 NA -0.5 -6.53 -0.34 2.43e-10 Drug-induced liver injury (nitrofurantoin); CRC trans rs1728785 0.688 rs698729 chr16:68624205 G/C cg04657470 chr2:198365150 HSPE1;HSPD1 0.59 7.19 0.37 4.49e-12 Ulcerative colitis; CRC cis rs3771570 1.000 rs17386695 chr2:242379751 A/G cg21155796 chr2:242212141 HDLBP -0.63 -6.87 -0.35 3.14e-11 Prostate cancer; CRC cis rs1448094 0.872 rs10863147 chr12:86408441 G/C cg18827107 chr12:86230957 RASSF9 -0.36 -5.77 -0.3 1.81e-8 Major depressive disorder; CRC cis rs9914544 1.000 rs7223231 chr17:18811846 C/T cg26306683 chr17:18585705 ZNF286B 0.47 6.84 0.35 3.92e-11 Educational attainment (years of education); CRC cis rs28374715 0.578 rs17730589 chr15:41600878 T/C cg18705301 chr15:41695430 NDUFAF1 -1.1 -18.91 -0.72 1.65e-54 Ulcerative colitis; CRC cis rs12134245 0.747 rs17501512 chr1:92012481 C/G cg07090678 chr1:91966139 CDC7 -0.43 -7.26 -0.37 2.86e-12 Breast cancer; CRC cis rs8031584 0.679 rs34017474 chr15:31230611 T/C cg08704250 chr15:31115839 NA -0.34 -6.48 -0.34 3.33e-10 Huntington's disease progression; CRC trans rs1346081 0.786 rs1425645 chr4:68028175 C/T cg11470399 chr16:23690492 PLK1 0.5 6.07 0.32 3.56e-9 Intelligence (multi-trait analysis); CRC cis rs8067545 0.641 rs203466 chr17:19809953 C/G cg13482628 chr17:19912719 NA -0.37 -5.72 -0.3 2.41e-8 Schizophrenia; CRC cis rs2179367 0.959 rs536203 chr6:149651264 G/A cg07828024 chr6:149772892 ZC3H12D -0.37 -5.94 -0.31 7.09e-9 Dupuytren's disease; CRC cis rs875971 0.862 rs4718319 chr7:65652784 C/A cg18876405 chr7:65276391 NA -0.52 -8.74 -0.43 1.22e-16 Aortic root size; CRC cis rs2530545 0.619 rs6955780 chr7:34662348 C/G cg14401837 chr7:34697493 NPSR1 0.42 6.27 0.33 1.14e-9 IgG glycosylation; CRC cis rs12701220 0.725 rs13242971 chr7:1055515 C/T cg02733842 chr7:1102375 C7orf50 -0.81 -9.74 -0.47 7.33e-20 Bronchopulmonary dysplasia; CRC trans rs1814175 0.754 rs10839453 chr11:49955815 A/T cg11707556 chr5:10655725 ANKRD33B -0.44 -8.35 -0.42 1.88e-15 Height; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg07152591 chr5:132083105 CCNI2 0.43 6.06 0.32 3.67e-9 Response to antipsychotic treatment; CRC cis rs7973719 0.833 rs11044332 chr12:7358768 C/A cg07052231 chr12:7363540 PEX5 0.52 8.4 0.42 1.39e-15 IgG glycosylation; CRC cis rs17152411 1.000 rs10901837 chr10:126614618 G/A cg07906193 chr10:126599966 NA 0.62 6.89 0.36 2.85e-11 Height; CRC cis rs9911578 0.967 rs72628392 chr17:56506160 A/G cg12560992 chr17:57184187 TRIM37 -0.88 -14.89 -0.63 1.1e-38 Intelligence (multi-trait analysis); CRC cis rs3008870 1.000 rs912797 chr1:67413478 A/G cg08660285 chr1:67390436 MIER1;WDR78 1.02 15.1 0.64 1.64e-39 Lymphocyte percentage of white cells; CRC cis rs7618915 0.501 rs13079063 chr3:52744460 A/G cg18404041 chr3:52824283 ITIH1 -0.4 -8.26 -0.41 3.57e-15 Bipolar disorder; CRC cis rs9372498 0.536 rs9481808 chr6:118784571 G/A cg01339444 chr6:118972232 C6orf204 0.54 6.02 0.32 4.65e-9 Diastolic blood pressure; CRC cis rs2404602 0.967 rs2083762 chr15:76907376 T/C cg23625390 chr15:77176239 SCAPER 0.59 9.11 0.45 8.04e-18 Blood metabolite levels; CRC cis rs10504229 0.683 rs7827881 chr8:58132137 C/T cg24829409 chr8:58192753 C8orf71 -0.54 -7.95 -0.4 3.11e-14 Developmental language disorder (linguistic errors); CRC cis rs904251 0.561 rs4714071 chr6:37474393 C/T cg25019722 chr6:37503610 NA -0.38 -6.59 -0.34 1.75e-10 Cognitive performance; CRC cis rs17270561 0.609 rs4712963 chr6:25740502 C/T cg16482183 chr6:26056742 HIST1H1C 0.82 10.4 0.5 4.48e-22 Iron status biomarkers; CRC cis rs9926296 0.605 rs8046243 chr16:89852133 A/G cg04287289 chr16:89883240 FANCA 0.83 15.26 0.64 3.89e-40 Vitiligo; CRC trans rs2228479 0.850 rs11639906 chr16:89798183 T/C cg21302420 chr1:112162376 RAP1A 0.72 5.96 0.31 6.55e-9 Skin colour saturation; CRC cis rs2795502 0.564 rs11239844 chr10:43453365 G/A cg20628663 chr10:43360327 NA 0.56 6.91 0.36 2.57e-11 Blood protein levels; CRC cis rs4808199 0.847 rs34647936 chr19:19548239 T/G cg03709012 chr19:19516395 GATAD2A 1.04 12.65 0.57 3.79e-30 Nonalcoholic fatty liver disease; CRC cis rs9549367 0.601 rs558869 chr13:113849932 G/T cg00898013 chr13:113819073 PROZ 0.5 7.43 0.38 9.39e-13 Platelet distribution width; CRC trans rs12200782 0.577 rs3757144 chr6:26380922 G/C cg25800765 chr12:85673347 ALX1 0.26 5.98 0.31 5.79e-9 Small cell lung carcinoma; CRC cis rs7662987 0.517 rs2602845 chr4:100023944 T/C cg12011299 chr4:100065546 ADH4 0.49 9.27 0.46 2.46e-18 Smoking initiation; CRC cis rs11758351 0.925 rs2183948 chr6:26180332 A/G cg10723962 chr6:26240782 HIST1H4F -0.38 -5.84 -0.31 1.22e-8 Gout;Renal underexcretion gout; CRC cis rs34779708 0.931 rs9663401 chr10:35278849 G/T cg03585969 chr10:35415529 CREM 0.66 8.82 0.44 6.68e-17 Inflammatory bowel disease;Crohn's disease; CRC cis rs4604732 0.588 rs7549495 chr1:247627806 G/A cg12758973 chr1:247694275 LOC148824;OR2C3 0.38 5.75 0.3 2.03e-8 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CRC trans rs3942852 0.594 rs10769311 chr11:48094009 T/C cg15704280 chr7:45808275 SEPT13 -0.69 -9.75 -0.47 6.88e-20 Acute lymphoblastic leukemia (childhood); CRC cis rs10484885 0.878 rs72921934 chr6:90579464 T/A cg13799429 chr6:90582589 CASP8AP2 -0.72 -7.69 -0.39 1.76e-13 QRS interval (sulfonylurea treatment interaction); CRC cis rs10499694 0.967 rs7786398 chr7:50612906 G/A cg14593290 chr7:50529359 DDC -0.48 -6.87 -0.35 3.22e-11 Body mass index; CRC cis rs6735179 0.688 rs2382563 chr2:1763599 T/C cg19300414 chr2:1746591 PXDN 0.35 6.31 0.33 8.85e-10 Response to antipsychotic treatment; CRC cis rs2074585 0.806 rs8033813 chr15:90999715 A/T cg22089800 chr15:90895588 ZNF774 0.57 9.3 0.46 2.05e-18 Basophil percentage of granulocytes;White blood cell count (basophil);Basophil percentage of white cells; CRC cis rs9399137 0.507 rs4594969 chr6:135285586 A/T cg24558204 chr6:135376177 HBS1L 0.6 8.9 0.44 3.69e-17 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; CRC cis rs1215050 0.791 rs2123100 chr4:98803747 T/C cg05340658 chr4:99064831 C4orf37 0.47 6.96 0.36 1.84e-11 Waist-to-hip ratio adjusted for body mass index; CRC cis rs1868673 1.000 rs28514580 chr3:150154365 G/T cg04908077 chr3:150187338 NA -0.33 -5.65 -0.3 3.49e-8 Waist circumference; CRC cis rs1005277 0.541 rs2263163 chr10:38389887 G/A cg00409905 chr10:38381863 ZNF37A -0.67 -11.17 -0.52 9.08e-25 Extrinsic epigenetic age acceleration; CRC cis rs6951245 0.935 rs61910751 chr7:1097895 A/G cg18402987 chr7:1209562 NA 0.67 7.17 0.37 5.02e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs3126085 0.935 rs4421596 chr1:152181673 G/A cg09127314 chr1:152161683 NA 0.53 6.69 0.35 9.52e-11 Atopic dermatitis; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg01129751 chr2:42796040 MTA3 -0.39 -6.08 -0.32 3.35e-9 Myopia (pathological); CRC cis rs823143 0.570 rs823084 chr1:205798313 G/T cg24503407 chr1:205819492 PM20D1 0.63 9.73 0.47 7.83e-20 Monocyte percentage of white cells; CRC cis rs7618501 0.966 rs7372966 chr3:49788969 T/C cg24308560 chr3:49941425 MST1R 0.48 7.49 0.38 6.49e-13 Intelligence (multi-trait analysis); CRC cis rs853679 0.517 rs9393898 chr6:28130376 G/T cg12172441 chr6:28176163 NA 0.63 7.43 0.38 9.41e-13 Depression; CRC cis rs73206853 0.764 rs55823622 chr12:110781628 G/A cg12870014 chr12:110450643 ANKRD13A 0.8 7.71 0.39 1.55e-13 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC cis rs2120019 0.938 rs8040169 chr15:75370958 C/A cg09165964 chr15:75287851 SCAMP5 -0.8 -12.62 -0.57 4.92e-30 Blood trace element (Zn levels); CRC cis rs7647973 0.626 rs1463728 chr3:49647404 T/A cg03060546 chr3:49711283 APEH 0.66 7.71 0.39 1.47e-13 Menarche (age at onset); CRC cis rs798554 0.759 rs1636255 chr7:2892804 A/C cg19717773 chr7:2847554 GNA12 0.49 6.89 0.35 2.9e-11 Height; CRC cis rs10982256 1.000 rs10982256 chr9:117260834 A/G cg13636371 chr9:117264095 DFNB31 -0.37 -7.16 -0.37 5.36e-12 Bipolar disorder; CRC cis rs17270561 0.609 rs4711095 chr6:25726774 A/C cg17691542 chr6:26056736 HIST1H1C 0.73 9.31 0.46 1.82e-18 Iron status biomarkers; CRC cis rs2576037 0.583 rs4890698 chr18:44489725 A/G cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.64 11.1 0.52 1.54e-24 Personality dimensions; CRC cis rs10504229 0.683 rs7835498 chr8:58129780 A/C cg02290350 chr8:58132656 NA -0.58 -8.16 -0.41 7.29e-15 Developmental language disorder (linguistic errors); CRC cis rs858239 0.932 rs199355 chr7:23296533 C/T cg00469287 chr7:23338798 C7orf30 0.42 5.7 0.3 2.65e-8 Cerebrospinal fluid biomarker levels; CRC cis rs9467711 0.560 rs6900665 chr6:26487169 C/T cg12315302 chr6:26189340 HIST1H4D 0.72 5.79 0.3 1.66e-8 Autism spectrum disorder or schizophrenia; CRC cis rs7647973 1.000 rs3866330 chr3:49582994 T/C cg20833759 chr3:49053208 WDR6;DALRD3 0.55 8.45 0.42 9.64e-16 Menarche (age at onset); CRC cis rs2243480 0.708 rs35310401 chr7:65390359 A/G cg18252515 chr7:66147081 NA -1.08 -12.66 -0.57 3.44e-30 Diabetic kidney disease; CRC cis rs2979489 0.786 rs2979514 chr8:30399461 A/C cg26383811 chr8:30366931 RBPMS -0.69 -10.1 -0.49 4.6e-21 Mean corpuscular hemoglobin;Plateletcrit;Neutrophil count;Granulocyte count;Sum basophil neutrophil counts;Mean corpuscular volume;Myeloid white cell count;Sum neutrophil eosinophil counts; CRC cis rs2976388 0.578 rs3758081 chr8:143824373 A/G cg24634471 chr8:143751801 JRK -0.5 -6.74 -0.35 7.2e-11 Urinary tract infection frequency; CRC cis rs8177253 1.000 rs6762719 chr3:133480817 A/G cg16262614 chr3:133464971 TF 0.33 5.81 0.3 1.49e-8 Iron status biomarkers; CRC cis rs4819052 0.851 rs35560973 chr21:46662573 T/C cg11663144 chr21:46675770 NA -0.73 -12.08 -0.55 4.74e-28 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs1401999 1.000 rs4148575 chr3:183702275 A/G cg01324343 chr3:183735012 ABCC5 0.77 13.88 0.61 8.3e-35 Anterior chamber depth; CRC cis rs4727027 0.866 rs12666477 chr7:148812322 A/G cg12479418 chr7:148823350 ZNF425;ZNF398 0.43 5.86 0.31 1.12e-8 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC cis rs3617 0.652 rs60332615 chr3:52867595 C/A cg07507251 chr3:52567010 NT5DC2 -0.4 -6.2 -0.32 1.67e-9 Red blood cell count;Autism spectrum disorder or schizophrenia; CRC cis rs1008375 1.000 rs4698641 chr4:17642630 C/T cg02297831 chr4:17616191 MED28 0.49 6.59 0.34 1.75e-10 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs1023500 0.573 rs133380 chr22:42468910 C/T cg11915388 chr22:42470451 FAM109B -0.38 -5.7 -0.3 2.62e-8 Schizophrenia; CRC cis rs7264396 0.887 rs224370 chr20:34073379 G/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.42 -6.92 -0.36 2.37e-11 Total cholesterol levels; CRC cis rs7849270 0.959 rs713218 chr9:131900770 G/C cg13538475 chr9:131942899 NA -0.32 -6.36 -0.33 6.59e-10 Blood metabolite ratios; CRC cis rs11997175 0.713 rs6997661 chr8:33638554 A/G cg04338863 chr8:33670619 NA -0.33 -5.7 -0.3 2.68e-8 Body mass index; CRC cis rs1863824 0.625 rs11202024 chr10:88168024 C/A cg07322936 chr10:88137208 NA -0.64 -8.71 -0.43 1.5e-16 Schizophrenia; CRC trans rs561341 1.000 rs55978022 chr17:30275937 T/C cg27661571 chr11:113659931 NA -0.96 -11.24 -0.53 5.07e-25 Hip circumference adjusted for BMI; CRC trans rs2243480 0.711 rs1626926 chr7:65435792 C/T cg10756647 chr7:56101905 PSPH 0.73 8.16 0.41 7.04e-15 Diabetic kidney disease; CRC cis rs7659604 0.676 rs6534323 chr4:122695888 G/A cg06713675 chr4:122721982 EXOSC9 -0.5 -8.08 -0.41 1.29e-14 Type 2 diabetes; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg15013526 chr3:170588137 RPL22L1 -0.41 -6.45 -0.34 4.06e-10 Myopia (pathological); CRC cis rs1799949 1.000 rs11079056 chr17:41300799 C/A cg25072359 chr17:41440525 NA 0.46 6.97 0.36 1.79e-11 Menopause (age at onset); CRC cis rs7223966 0.515 rs2727315 chr17:61961458 C/T cg23090583 chr17:61904693 PSMC5;FTSJ3 0.52 6.43 0.33 4.61e-10 Hip circumference adjusted for BMI;Body mass index; CRC cis rs4862750 0.914 rs1991256 chr4:187875330 A/G cg03647317 chr4:187891568 NA -0.55 -10.27 -0.49 1.19e-21 Lobe attachment (rater-scored or self-reported); CRC cis rs2032447 0.507 rs199748 chr6:25909045 C/G cg18357526 chr6:26021779 HIST1H4A 0.57 7.48 0.38 6.9e-13 Intelligence (multi-trait analysis); CRC cis rs17401966 1.000 rs17411502 chr1:10431158 T/C cg19773385 chr1:10388646 KIF1B -0.57 -7.81 -0.4 7.58e-14 Hepatocellular carcinoma; CRC trans rs57590327 0.527 rs9845467 chr3:81614473 G/A cg23387109 chr10:94051229 MARCH5;CPEB3 0.45 5.96 0.31 6.36e-9 Extraversion; CRC cis rs2949837 0.581 rs2965072 chr7:45980751 G/T cg15898840 chr7:45960834 IGFBP3 0.47 7.84 0.4 6.19e-14 Sitting height ratio; CRC trans rs1455244 0.700 rs7229302 chr18:11508904 G/T cg09060093 chr1:26202137 NA 0.4 6.07 0.32 3.5e-9 Schizophrenia; CRC cis rs6831352 0.918 rs13113166 chr4:100050528 A/G cg13256891 chr4:100009986 ADH5 -0.66 -8.89 -0.44 4.04e-17 Alcohol dependence; CRC cis rs11677370 0.603 rs10174064 chr2:3849806 C/T cg17052675 chr2:3827356 NA -0.65 -10.63 -0.51 6.91e-23 Type 2 diabetes; CRC cis rs9814567 0.896 rs2177602 chr3:134245866 A/G cg06541857 chr3:134203789 ANAPC13;CEP63 -0.4 -6.12 -0.32 2.65e-9 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC trans rs10242455 0.571 rs28365067 chr7:99272310 G/A cg09045935 chr12:6379348 NA 0.84 6.31 0.33 8.84e-10 Blood metabolite levels; CRC cis rs846178 1 rs846178 chr4:2485615 A/C cg16474684 chr4:2470049 RNF4 -0.46 -5.96 -0.31 6.5e-9 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs7630877 0.719 rs73057311 chr3:179664197 A/G cg18765712 chr3:179670323 PEX5L 0.5 6.96 0.36 1.81e-11 Type 2 diabetes; CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg12877462 chr4:100484858 RG9MTD2;MTTP -0.52 -6.47 -0.34 3.51e-10 Diisocyanate-induced asthma; CRC cis rs12477438 0.765 rs7571390 chr2:99626593 C/T cg14399236 chr2:99771627 LIPT1;TSGA10 -0.61 -8.39 -0.42 1.46e-15 Chronic sinus infection; CRC cis rs2710642 0.566 rs2710651 chr2:63166379 G/A cg17519650 chr2:63277830 OTX1 0.5 7.59 0.39 3.23e-13 LDL cholesterol levels;LDL cholesterol; CRC cis rs1448094 0.511 rs4897823 chr12:86161484 C/T cg25456477 chr12:86230367 RASSF9 0.37 6.38 0.33 5.98e-10 Major depressive disorder; CRC cis rs2120019 1.000 rs7175720 chr15:75348962 C/G cg17294928 chr15:75287854 SCAMP5 0.77 10.89 0.51 8.67e-24 Blood trace element (Zn levels); CRC cis rs1475911 0.708 rs66994219 chr21:43521647 G/A cg14562523 chr21:43528734 C21orf128;UMODL1 -0.63 -9.78 -0.47 5.56e-20 IgG glycosylation; CRC cis rs738321 0.757 rs4820315 chr22:38518731 C/T cg25457927 chr22:38595422 NA -0.33 -6.33 -0.33 8.06e-10 Breast cancer; CRC cis rs7811142 0.943 rs66958101 chr7:100074020 G/A cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.97 13.16 0.59 4.62e-32 Platelet count; CRC cis rs10751667 0.666 rs7103585 chr11:971166 T/C cg01483505 chr11:975446 AP2A2 0.46 7.66 0.39 2.11e-13 Alzheimer's disease (late onset); CRC trans rs1933755 0.541 rs35616742 chr6:130917784 C/T cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.89 -6.62 -0.34 1.48e-10 Colorectal cancer (calcium intake interaction); CRC cis rs4908760 0.899 rs6577496 chr1:8581227 C/A cg20416874 chr1:8611966 RERE -0.46 -6.6 -0.34 1.61e-10 Vitiligo; CRC cis rs9611565 1.000 rs5751086 chr22:41768862 C/T cg03806693 chr22:41940476 POLR3H -0.59 -8.32 -0.42 2.45e-15 Vitiligo; CRC cis rs896854 0.812 rs12546365 chr8:95911477 T/C cg13393036 chr8:95962371 TP53INP1 -0.5 -8.26 -0.41 3.64e-15 Type 2 diabetes; CRC trans rs2303319 0.504 rs12470743 chr2:162611202 G/A cg18122310 chr12:50236657 BCDIN3D -0.73 -6.35 -0.33 7.23e-10 Cognitive function; CRC cis rs9649213 0.593 rs34534766 chr7:97920871 G/C cg21770322 chr7:97807741 LMTK2 0.54 9.08 0.45 1.02e-17 Prostate cancer (SNP x SNP interaction); CRC cis rs73195822 0.506 rs55948838 chr12:111142793 C/T cg12870014 chr12:110450643 ANKRD13A 0.75 8.89 0.44 4.25e-17 Itch intensity from mosquito bite; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg17569080 chr11:93862630 PANX1 0.43 6.03 0.32 4.35e-9 Response to antipsychotic treatment; CRC cis rs7615952 0.599 rs6803160 chr3:125709554 G/T cg05084668 chr3:125655381 ALG1L -0.46 -6.7 -0.35 9.13e-11 Blood pressure (smoking interaction); CRC cis rs7408868 0.908 rs2074619 chr19:15276919 G/A cg14696996 chr19:15285081 NOTCH3 0.96 9.0 0.44 1.82e-17 Pulse pressure; CRC cis rs6860806 0.507 rs270606 chr5:131650867 A/G cg27615366 chr5:131592974 PDLIM4 0.34 5.81 0.31 1.48e-8 Breast cancer; CRC trans rs2303319 0.504 rs2175142 chr2:162450124 T/C cg27113153 chr11:123612418 ZNF202 -0.7 -6.15 -0.32 2.28e-9 Cognitive function; CRC cis rs208520 1.000 rs72882100 chr6:66981495 G/C cg07460842 chr6:66804631 NA 0.91 11.21 0.53 6.6e-25 Exhaled nitric oxide output; CRC cis rs9733 0.596 rs72702504 chr1:150635374 G/C cg17724175 chr1:150552817 MCL1 0.58 9.4 0.46 9.25e-19 Tonsillectomy; CRC cis rs2404602 0.716 rs66754747 chr15:76828568 G/A cg23625390 chr15:77176239 SCAPER 0.47 6.81 0.35 4.6e-11 Blood metabolite levels; CRC cis rs875971 0.862 rs10278014 chr7:66051264 C/T cg18876405 chr7:65276391 NA -0.53 -8.61 -0.43 3.18e-16 Aortic root size; CRC cis rs875971 0.898 rs6977501 chr7:65693342 T/C cg18912574 chr7:65842487 NCRNA00174 -0.37 -6.35 -0.33 7.35e-10 Aortic root size; CRC cis rs2739330 0.828 rs2330635 chr22:24251344 T/C cg16132339 chr22:24313637 DDTL;DDT 0.63 9.9 0.48 2.09e-20 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs2243480 1.000 rs2243480 chr7:65599196 C/T cg18252515 chr7:66147081 NA -1.08 -12.42 -0.56 2.72e-29 Diabetic kidney disease; CRC cis rs4665809 0.556 rs4665322 chr2:26434605 C/G cg26119090 chr2:26468346 HADHA;HADHB -0.98 -14.12 -0.61 1.04e-35 Gut microbiome composition (summer); CRC trans rs7944735 0.786 rs7123436 chr11:48013484 G/A cg03929089 chr4:120376271 NA 0.56 6.37 0.33 6.41e-10 Intraocular pressure; CRC cis rs751728 0.965 rs9394165 chr6:33731408 G/A cg25922239 chr6:33757077 LEMD2 0.59 8.64 0.43 2.51e-16 Crohn's disease; CRC cis rs807029 0.577 rs3740489 chr10:102754238 A/G cg04662943 chr10:102668895 NA 0.62 7.28 0.37 2.51e-12 Ejection fraction in Tripanosoma cruzi seropositivity; CRC cis rs5769765 0.908 rs9616388 chr22:50313438 T/C cg22709217 chr22:50311962 ALG12;CRELD2 -1.12 -18.13 -0.71 2.07e-51 Schizophrenia; CRC cis rs4713118 0.513 rs149945 chr6:28002853 T/C cg06470822 chr6:28175283 NA 0.79 12.11 0.56 3.51e-28 Parkinson's disease; CRC cis rs28374715 0.578 rs10518717 chr15:41623368 C/G cg18705301 chr15:41695430 NDUFAF1 -1.11 -17.98 -0.7 7.63e-51 Ulcerative colitis; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg26869849 chr2:27632522 PPM1G 0.47 6.3 0.33 9.33e-10 Anxiety disorder; CRC cis rs763121 1.000 rs763121 chr22:38879940 C/T cg06544989 chr22:39130855 UNC84B -0.43 -6.48 -0.34 3.26e-10 Menopause (age at onset); CRC cis rs1129187 0.967 rs3805951 chr6:42937176 C/A cg27588902 chr6:42928151 GNMT -0.39 -6.98 -0.36 1.66e-11 Alzheimer's disease in APOE e4+ carriers; CRC cis rs1129187 0.967 rs3805951 chr6:42937176 C/A cg26304593 chr6:42947056 PEX6 -0.41 -5.75 -0.3 2.05e-8 Alzheimer's disease in APOE e4+ carriers; CRC cis rs9902453 0.838 rs9646437 chr17:28209065 G/A cg26525008 chr17:28256777 EFCAB5;SSH2 0.59 8.81 0.44 7.18e-17 Coffee consumption (cups per day); CRC cis rs9916302 0.851 rs11078907 chr17:37662954 C/T cg15445000 chr17:37608096 MED1 0.43 9.5 0.46 4.37e-19 Glomerular filtration rate (creatinine); CRC cis rs7149337 0.836 rs35345236 chr14:51671817 T/C cg23942311 chr14:51606299 NA 0.74 13.6 0.6 9.8e-34 Cancer; CRC cis rs6540559 0.611 rs926347 chr1:209965193 T/C cg21951975 chr1:209979733 IRF6 0.49 6.57 0.34 2.02e-10 Cleft lip with or without cleft palate; CRC cis rs13191362 0.935 rs34709632 chr6:163048380 A/G cg06582575 chr6:163149167 PACRG;PARK2 0.91 11.21 0.53 6.25e-25 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs514406 0.929 rs483073 chr1:53314084 T/C cg25767906 chr1:53392781 SCP2 -0.5 -8.3 -0.42 2.74e-15 Monocyte count; CRC cis rs6459788 0.720 rs11768765 chr7:157253133 C/T cg01766193 chr7:157202248 DNAJB6 -0.34 -5.62 -0.3 3.99e-8 Epstein-Barr virus copy number in lymphoblastoid cell lines; CRC cis rs754466 0.651 rs11002317 chr10:79617648 G/A cg17075019 chr10:79541650 NA -0.89 -15.36 -0.65 1.55e-40 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs10504229 1.000 rs67546820 chr8:58168567 G/A cg02290350 chr8:58132656 NA -0.41 -6.08 -0.32 3.25e-9 Developmental language disorder (linguistic errors); CRC cis rs4713118 0.824 rs2092075 chr6:27749330 G/C cg12172441 chr6:28176163 NA 0.54 7.07 0.36 9.53e-12 Parkinson's disease; CRC cis rs524281 0.861 rs6591208 chr11:65949689 A/C cg14036092 chr11:66035641 RAB1B -0.47 -5.71 -0.3 2.54e-8 Electroencephalogram traits; CRC cis rs9611565 0.512 rs9607841 chr22:42186838 G/A cg03806693 chr22:41940476 POLR3H -1.08 -13.36 -0.59 8.21e-33 Vitiligo; CRC trans rs10506458 0.834 rs17738403 chr12:63389200 A/G cg22491629 chr6:157744540 C6orf35 -0.73 -8.33 -0.42 2.18e-15 Hemostatic factors and hematological phenotypes; CRC trans rs6956675 1.000 rs10229492 chr7:62580546 G/A cg01314568 chr7:57830625 NA -0.68 -9.3 -0.46 2.06e-18 Obesity-related traits; CRC trans rs6703335 0.870 rs10803142 chr1:243598234 A/G cg03140480 chr1:2703494 NA 0.38 5.98 0.31 5.9e-9 Schizophrenia;Schizophrenia, schizoaffective disorder or bipolar disorder; CRC cis rs2985684 0.901 rs7146248 chr14:50112067 C/T cg10008539 chr14:50087325 RPL36AL;MGAT2 -0.44 -5.92 -0.31 7.99e-9 Carotid intima media thickness; CRC cis rs4481887 0.504 rs4508045 chr1:248373567 G/A cg00666640 chr1:248458726 OR2T12 0.43 6.77 0.35 5.91e-11 Common traits (Other); CRC cis rs9611565 0.921 rs8137373 chr22:41729216 A/G cg03806693 chr22:41940476 POLR3H 0.83 11.88 0.55 2.57e-27 Vitiligo; CRC cis rs514406 0.929 rs2607095 chr1:53325639 T/C cg08859206 chr1:53392774 SCP2 -0.45 -7.04 -0.36 1.16e-11 Monocyte count; CRC cis rs10504229 0.683 rs16921807 chr8:58105967 C/T cg04204079 chr8:58130323 NA -0.46 -5.79 -0.3 1.67e-8 Developmental language disorder (linguistic errors); CRC cis rs6952808 0.798 rs28970524 chr7:1927484 C/T cg02951883 chr7:2050386 MAD1L1 -0.72 -11.49 -0.54 6.44e-26 Bipolar disorder and schizophrenia; CRC cis rs72781680 0.848 rs6748727 chr2:24041058 G/A cg08917208 chr2:24149416 ATAD2B 0.9 9.13 0.45 6.96e-18 Lymphocyte counts; CRC cis rs7605827 0.930 rs12692275 chr2:15716781 C/T cg19274914 chr2:15703543 NA 0.4 6.14 0.32 2.32e-9 Educational attainment (years of education); CRC cis rs8177179 0.967 rs4443173 chr3:133439378 A/G cg17775713 chr3:133465469 TF 0.35 6.28 0.33 1.07e-9 Iron status biomarkers (transferrin levels); CRC cis rs593982 0.858 rs537385 chr11:65504900 G/A cg08755490 chr11:65554678 OVOL1 1.2 18.64 0.72 2.04e-53 Atopic dermatitis; CRC cis rs2286885 1.000 rs10733679 chr9:129242416 C/T cg15282417 chr9:129245246 FAM125B 0.45 8.24 0.41 4.17e-15 Intraocular pressure; CRC trans rs1005277 0.579 rs2472176 chr10:38382921 T/C cg27523141 chr10:43048294 ZNF37B 0.5 7.23 0.37 3.41e-12 Extrinsic epigenetic age acceleration; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg12444390 chr22:24989260 C22orf36;GGT1 0.35 6.11 0.32 2.87e-9 Liver disease severity in Alagille syndrome; CRC cis rs4713118 0.662 rs156744 chr6:27967274 G/A cg23161317 chr6:28129485 ZNF389 0.44 6.12 0.32 2.64e-9 Parkinson's disease; CRC cis rs9326248 0.813 rs588534 chr11:117068504 A/G cg11861562 chr11:117069780 TAGLN 0.33 6.1 0.32 3.05e-9 Blood protein levels; CRC cis rs1799949 0.965 rs11654051 chr17:41419656 C/T cg05368731 chr17:41323189 NBR1 0.65 9.39 0.46 1.03e-18 Menopause (age at onset); CRC cis rs561341 1.000 rs506766 chr17:30289659 T/C cg00745463 chr17:30367425 LRRC37B -0.91 -9.6 -0.47 2.07e-19 Hip circumference adjusted for BMI; CRC cis rs7517126 1.000 rs7548070 chr1:196892322 G/A cg13682187 chr1:196946512 CFHR5 -0.4 -5.89 -0.31 9.64e-9 Blood protein levels; CRC cis rs28386778 0.897 rs716880 chr17:61902822 C/G cg11494091 chr17:61959527 GH2 0.6 10.1 0.49 4.51e-21 Prudent dietary pattern; CRC cis rs7089973 0.604 rs8181444 chr10:116588981 C/T cg23260525 chr10:116636907 FAM160B1 0.35 8.07 0.41 1.34e-14 Bipolar disorder or attention deficit hyperactivity disorder; CRC cis rs6502050 0.699 rs9901808 chr17:80107814 C/T cg09264619 chr17:80180166 NA -0.35 -5.82 -0.31 1.41e-8 Life satisfaction; CRC cis rs11628318 0.525 rs10129838 chr14:103154317 T/C cg12046867 chr14:103022105 NA 0.67 8.04 0.41 1.67e-14 Platelet count; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg18876457 chr1:160071037 NA 0.54 7.85 0.4 5.79e-14 Response to antipsychotic treatment; CRC cis rs875971 0.862 rs10263690 chr7:65766453 G/C cg18252515 chr7:66147081 NA 0.4 5.63 0.3 3.84e-8 Aortic root size; CRC cis rs6502050 0.835 rs8078950 chr17:80122327 T/G cg22110888 chr17:80059540 CCDC57 0.4 6.38 0.33 5.96e-10 Life satisfaction; CRC cis rs4474465 0.688 rs4945302 chr11:78283454 T/C cg27205649 chr11:78285834 NARS2 0.53 6.85 0.35 3.63e-11 Alzheimer's disease (survival time); CRC cis rs561341 1.000 rs68140514 chr17:30335781 T/C cg00745463 chr17:30367425 LRRC37B -0.73 -8.57 -0.43 4.2e-16 Hip circumference adjusted for BMI; CRC cis rs4243830 0.850 rs12410405 chr1:6581283 C/G cg05709478 chr1:6581295 PLEKHG5 0.61 7.84 0.4 6.13e-14 Body mass index; CRC cis rs4727027 0.866 rs10435245 chr7:148816081 C/G cg12479418 chr7:148823350 ZNF425;ZNF398 0.46 6.28 0.33 1.09e-9 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC cis rs12995491 0.698 rs34352413 chr2:88498754 T/G cg14558114 chr2:88469736 THNSL2 -0.47 -6.86 -0.35 3.5e-11 Response to metformin (IC50); CRC cis rs12220238 1.000 rs10824083 chr10:75911342 C/G cg19889307 chr10:75911429 ADK;AP3M1 0.64 6.42 0.33 4.71e-10 Soluble interleukin-2 receptor subunit alpha; CRC cis rs3733585 0.673 rs4519796 chr4:9955936 A/G cg11266682 chr4:10021025 SLC2A9 -0.47 -9.66 -0.47 1.35e-19 Cleft plate (environmental tobacco smoke interaction); CRC cis rs10883723 0.773 rs2296578 chr10:104240974 C/G cg22532475 chr10:104410764 TRIM8 -0.35 -6.28 -0.33 1.06e-9 Allergic disease (asthma, hay fever or eczema); CRC cis rs4803468 1.000 rs166925 chr19:41926098 T/C cg09537434 chr19:41945824 ATP5SL -0.97 -18.39 -0.71 1.96e-52 Height; CRC cis rs10242455 0.702 rs28753399 chr7:98997259 C/T cg18809830 chr7:99032528 PTCD1 -1.12 -8.16 -0.41 7.01e-15 Blood metabolite levels; CRC trans rs2732480 1.000 rs2732480 chr12:48736303 A/C cg05117785 chr10:94050880 CPEB3;MARCH5 -0.43 -6.13 -0.32 2.47e-9 Hemoglobin concentration;Red blood cell count;Hematocrit; CRC cis rs1046896 0.627 rs7225515 chr17:80795783 C/T cg17346650 chr17:80929145 B3GNTL1 0.47 6.84 0.35 3.82e-11 Glycated hemoglobin levels; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg27056425 chr6:27776039 HIST1H2AI;HIST1H2BL 0.4 6.22 0.32 1.5e-9 Liver disease severity in Alagille syndrome; CRC cis rs72615157 0.613 rs56089143 chr7:99819844 G/A cg19337854 chr7:99768885 GPC2 0.44 5.89 0.31 9.65e-9 Lung function (FEV1/FVC); CRC cis rs597539 0.690 rs635529 chr11:68626294 C/T cg04772025 chr11:68637568 NA 0.5 7.36 0.38 1.49e-12 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs4604732 0.631 rs12036460 chr1:247626928 A/G cg02104434 chr1:247694406 LOC148824;OR2C3 0.6 8.82 0.44 6.67e-17 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CRC cis rs9549328 0.565 rs35988856 chr13:113617427 T/C cg25790453 chr13:113633590 MCF2L 0.44 7.62 0.39 2.7e-13 Systolic blood pressure; CRC cis rs7580658 0.963 rs12622436 chr2:128081682 C/A cg09760422 chr2:128146352 NA -0.37 -7.15 -0.37 5.52e-12 Protein C levels; CRC cis rs7615952 0.576 rs17523380 chr3:125802874 C/T cg18479299 chr3:125709523 NA -0.52 -6.75 -0.35 6.59e-11 Blood pressure (smoking interaction); CRC cis rs868943 0.714 rs66475830 chr6:116408802 T/C cg26893134 chr6:116381904 FRK 0.26 6.34 0.33 7.59e-10 Total cholesterol levels; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg16558908 chr1:33896237 NA 0.4 6.85 0.35 3.62e-11 Liver disease severity in Alagille syndrome; CRC cis rs12541335 0.639 rs35068739 chr8:22201719 T/C cg26039829 chr8:22132926 PIWIL2 0.53 9.27 0.46 2.46e-18 Hypertriglyceridemia; CRC cis rs9372498 0.505 rs17427284 chr6:118991953 A/T cg07617317 chr6:118971624 C6orf204 0.5 5.9 0.31 8.8e-9 Diastolic blood pressure; CRC cis rs9816226 0.590 rs869401 chr3:185826546 G/A cg00760338 chr3:185826511 ETV5 0.78 10.83 0.51 1.42e-23 Obesity;Body mass index; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg18604876 chr3:5164258 ARL8B 0.45 7.11 0.36 7.36e-12 Liver disease severity in Alagille syndrome; CRC cis rs58688157 0.549 rs11246192 chr11:572473 T/C cg16486109 chr11:613632 IRF7 0.59 10.51 0.5 1.82e-22 Systemic lupus erythematosus; CRC cis rs9611565 0.649 rs202614 chr22:41822150 A/C cg06481639 chr22:41940642 POLR3H 0.51 5.63 0.3 3.96e-8 Vitiligo; CRC cis rs561341 1.000 rs8064843 chr17:30245744 A/G cg19193384 chr17:30244184 NA -0.49 -6.72 -0.35 8.09e-11 Hip circumference adjusted for BMI; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg19315081 chr11:10326100 ADM 0.45 6.15 0.32 2.25e-9 Thyroid stimulating hormone; CRC cis rs853679 0.517 rs9393891 chr6:28079160 C/T cg15786705 chr6:28176104 NA 0.76 9.47 0.46 5.57e-19 Depression; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg00368989 chr15:59949771 GTF2A2 0.37 6.12 0.32 2.59e-9 Liver disease severity in Alagille syndrome; CRC cis rs13392177 0.684 rs6720449 chr2:219080978 G/A cg00012203 chr2:219082015 ARPC2 -0.5 -7.29 -0.37 2.34e-12 Pyoderma gangrenosum in inflammatory bowel disease; CRC cis rs16937 0.662 rs12137294 chr1:205182872 A/C cg24159697 chr1:205181237 DSTYK -0.33 -6.01 -0.31 4.83e-9 Schizophrenia; CRC cis rs10832963 0.961 rs10832954 chr11:18643559 G/A cg20219074 chr11:18656078 SPTY2D1 0.62 8.84 0.44 5.9e-17 Breast cancer; CRC cis rs7680126 0.596 rs11722185 chr4:10317482 C/G cg11266682 chr4:10021025 SLC2A9 -0.44 -6.73 -0.35 7.55e-11 Urate levels in lean individuals;Urate levels in overweight individuals;Urate levels in obese individuals; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg26801843 chr11:34073061 CAPRIN1 0.53 6.94 0.36 2.14e-11 Thyroid stimulating hormone; CRC cis rs6735179 0.729 rs2382561 chr2:1763501 C/T cg19300414 chr2:1746591 PXDN 0.34 6.11 0.32 2.8e-9 Response to antipsychotic treatment; CRC cis rs801193 0.591 rs9986881 chr7:66173040 A/G cg05627663 chr7:65219948 SNORA22;CCT6P1 0.54 7.94 0.4 3.17e-14 Aortic root size; CRC cis rs734999 0.545 rs41300092 chr1:2537838 C/T cg18854424 chr1:2615690 NA 0.4 7.67 0.39 2e-13 Ulcerative colitis; CRC cis rs7772486 0.776 rs2265467 chr6:146218339 T/A cg23711669 chr6:146136114 FBXO30 0.64 11.02 0.52 2.98e-24 Lobe attachment (rater-scored or self-reported); CRC cis rs28386778 0.897 rs2727328 chr17:61923564 G/A cg23090583 chr17:61904693 PSMC5;FTSJ3 1.03 20.18 0.74 1.67e-59 Prudent dietary pattern; CRC cis rs394563 0.591 rs237029 chr6:149717425 A/G cg11245181 chr6:149772854 ZC3H12D -0.53 -9.31 -0.46 1.89e-18 Dupuytren's disease; CRC trans rs2727020 0.576 rs61885308 chr11:49343363 G/A cg21153622 chr11:89784906 NA -0.49 -8.32 -0.42 2.37e-15 Coronary artery disease; CRC cis rs6912958 0.559 rs242281 chr6:88048916 A/C cg08069147 chr6:88032118 GJB7;C6orf162 0.68 11.0 0.52 3.58e-24 Monocyte percentage of white cells; CRC cis rs45544231 0.569 rs9933556 chr16:52548302 C/T cg09051775 chr16:52580266 TOX3 -0.38 -6.16 -0.32 2.15e-9 Restless legs syndrome; CRC cis rs2439831 0.850 rs28684672 chr15:44107662 C/T cg02155558 chr15:43621948 ADAL;LCMT2 0.73 7.99 0.4 2.28e-14 Lung cancer in ever smokers; CRC cis rs60871478 0.786 rs7807878 chr7:833878 T/C cg05535760 chr7:792225 HEATR2 -0.99 -12.31 -0.56 6.71e-29 Cerebrospinal P-tau181p levels; CRC trans rs11165623 0.602 rs12120893 chr1:97007132 C/T cg10631902 chr5:14652156 NA -0.37 -6.13 -0.32 2.54e-9 Hip circumference;Waist circumference; CRC trans rs1005277 0.579 rs176886 chr10:38403974 C/T cg23533926 chr12:111358616 MYL2 -0.52 -7.83 -0.4 6.66e-14 Extrinsic epigenetic age acceleration; CRC cis rs5757676 1.000 rs5757676 chr22:39841700 T/C cg05872129 chr22:39784769 NA -0.44 -6.45 -0.34 3.94e-10 IgG glycosylation; CRC cis rs9611565 0.559 rs7290990 chr22:41964357 C/A cg03806693 chr22:41940476 POLR3H -0.88 -11.06 -0.52 2.22e-24 Vitiligo; CRC trans rs531930 0.563 rs332607 chr6:124723354 C/T cg04130557 chr4:186760378 SORBS2 0.46 6.05 0.32 3.85e-9 Celiac disease; CRC cis rs10486722 0.603 rs10282595 chr7:41771004 T/G cg22138096 chr7:41772439 LOC285954 0.38 5.8 0.3 1.58e-8 Pit-and-Fissure caries; CRC cis rs909674 0.541 rs5750812 chr22:39793079 G/A cg11247378 chr22:39784982 NA -0.5 -10.11 -0.49 4.04e-21 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg05918679 chr19:49122382 RPL18;SPHK2 0.41 6.21 0.32 1.61e-9 Intelligence (multi-trait analysis); CRC cis rs6951245 1.000 rs113858334 chr7:1073476 A/G cg22907277 chr7:1156413 C7orf50 0.71 7.39 0.38 1.26e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs929354 0.742 rs11980541 chr7:156988776 G/C cg17757837 chr7:157058334 UBE3C 0.74 12.57 0.57 7.46e-30 Body mass index; CRC trans rs7618501 1.000 rs6785549 chr3:49736565 G/A cg21665057 chr3:196295764 WDR53;FBXO45 -0.87 -16.27 -0.67 4.48e-44 Intelligence (multi-trait analysis); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg06438815 chr21:46292710 PTTG1IP 0.43 6.39 0.33 5.51e-10 Response to antipsychotic treatment; CRC cis rs524281 0.861 rs485857 chr11:65959519 A/G cg14036092 chr11:66035641 RAB1B -0.47 -5.99 -0.31 5.5e-9 Electroencephalogram traits; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg01906197 chr14:23067002 ABHD4 0.51 6.79 0.35 5.22e-11 Thyroid stimulating hormone; CRC cis rs4635969 0.718 rs27068 chr5:1347239 C/T cg06550200 chr5:1325588 CLPTM1L -0.52 -6.68 -0.35 1e-10 Testicular germ cell tumor;Testicular germ cell cancer; CRC cis rs801193 1.000 rs2707836 chr7:66160435 A/C cg00343986 chr7:65444356 GUSB 0.49 7.22 0.37 3.53e-12 Aortic root size; CRC cis rs72627123 0.867 rs58894370 chr14:74485382 C/T cg12022184 chr14:74485813 ENTPD5;C14orf45 0.71 5.81 0.3 1.5e-8 Morning vs. evening chronotype; CRC cis rs2228479 1.000 rs117406136 chr16:89974605 C/T cg12064134 chr16:90016061 DEF8 -0.68 -6.02 -0.32 4.6e-9 Skin colour saturation; CRC cis rs10782582 0.609 rs5745347 chr1:76274520 C/T cg10523679 chr1:76189770 ACADM 0.4 5.71 0.3 2.58e-8 Daytime sleep phenotypes; CRC cis rs13108904 0.840 rs13106092 chr4:1257290 T/A cg21620606 chr4:1342894 KIAA1530 0.39 6.69 0.35 9.78e-11 Obesity-related traits; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg09209803 chr6:33588932 ITPR3 0.43 6.46 0.34 3.84e-10 Intelligence (multi-trait analysis); CRC cis rs875971 1.000 rs709597 chr7:65825983 A/G cg11764359 chr7:65958608 NA -0.6 -9.65 -0.47 1.4e-19 Aortic root size; CRC cis rs2982552 0.773 rs11155808 chr6:152056050 C/A cg22157087 chr6:152012887 ESR1 0.37 5.66 0.3 3.31e-8 Bone properties (heel); CRC cis rs992157 0.764 rs13020391 chr2:219184436 C/T cg04731861 chr2:219085781 ARPC2 0.3 5.71 0.3 2.54e-8 Colorectal cancer; CRC trans rs875971 0.660 rs2191268 chr7:66110224 C/T cg07079421 chr22:46933261 CELSR1 -0.43 -6.84 -0.35 3.91e-11 Aortic root size; CRC cis rs7267979 0.753 rs400357 chr20:25479058 A/G cg24626310 chr20:25276739 ABHD12;PYGB 0.33 5.82 0.31 1.4e-8 Liver enzyme levels (alkaline phosphatase); CRC cis rs6693567 0.545 rs7553647 chr1:150472666 C/T cg15654264 chr1:150340011 RPRD2 0.4 5.72 0.3 2.36e-8 Migraine; CRC cis rs1401999 1.000 rs6805913 chr3:183662924 T/G cg05044414 chr3:183734942 ABCC5 0.48 8.32 0.42 2.4e-15 Anterior chamber depth; CRC cis rs3741404 0.609 rs641378 chr11:63869493 T/C cg18225595 chr11:63971243 STIP1 0.41 6.61 0.34 1.52e-10 Platelet count; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg08631137 chr12:65003794 RASSF3 0.46 6.68 0.35 1e-10 Intelligence (multi-trait analysis); CRC cis rs910316 0.967 rs175432 chr14:75615246 C/G cg11812906 chr14:75593930 NEK9 -0.61 -9.56 -0.47 2.86e-19 Height; CRC cis rs7615952 0.576 rs66671308 chr3:125793526 T/G cg15145296 chr3:125709740 NA -0.59 -6.99 -0.36 1.54e-11 Blood pressure (smoking interaction); CRC cis rs9649213 0.593 rs2107716 chr7:97944744 G/A cg00277769 chr7:97922759 BAIAP2L1 -0.6 -10.46 -0.5 2.59e-22 Prostate cancer (SNP x SNP interaction); CRC cis rs6500602 0.626 rs7665 chr16:4562512 A/G cg14951292 chr16:4525986 HMOX2;NMRAL1 0.71 9.72 0.47 8.36e-20 Schizophrenia; CRC trans rs11026407 0.967 rs7127246 chr11:22060228 C/G cg22704520 chr2:200820451 C2orf60;C2orf47 -0.59 -6.01 -0.31 4.85e-9 Plasma thyroid-stimulating hormone levels; CRC trans rs1455244 0.700 rs7229302 chr18:11508904 G/T cg14274609 chr10:123687846 ATE1 0.45 7.05 0.36 1.03e-11 Schizophrenia; CRC cis rs1784581 0.588 rs1789988 chr6:162408472 C/T cg17173639 chr6:162384350 PARK2 -0.64 -10.12 -0.49 4.04e-21 Itch intensity from mosquito bite; CRC cis rs1150668 0.699 rs12214383 chr6:28223731 T/C cg12273811 chr6:28175739 NA -0.38 -5.83 -0.31 1.35e-8 Pubertal anthropometrics; CRC cis rs10504229 0.683 rs6980850 chr8:58127204 A/G cg02290350 chr8:58132656 NA -0.58 -8.16 -0.41 7.29e-15 Developmental language disorder (linguistic errors); CRC cis rs2274273 0.624 rs7154796 chr14:55771458 T/C cg10130446 chr14:55658398 DLGAP5 -0.4 -5.74 -0.3 2.18e-8 Protein biomarker; CRC cis rs4727027 0.754 rs11764892 chr7:148858916 G/A cg12479418 chr7:148823350 ZNF425;ZNF398 0.5 6.6 0.34 1.62e-10 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC cis rs1707322 0.721 rs12045096 chr1:46114428 A/G cg03146154 chr1:46216737 IPP 0.67 9.72 0.47 8.8e-20 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs7615952 0.599 rs1044215 chr3:125725559 C/G cg04553112 chr3:125709451 NA -0.48 -6.14 -0.32 2.33e-9 Blood pressure (smoking interaction); CRC cis rs12477438 0.520 rs7604557 chr2:99747829 A/G cg14399236 chr2:99771627 LIPT1;TSGA10 0.83 14.8 0.63 2.35e-38 Chronic sinus infection; CRC cis rs4664293 0.647 rs4635484 chr2:160454130 T/C cg08347373 chr2:160653686 CD302 -0.39 -6.49 -0.34 3.11e-10 Monocyte percentage of white cells; CRC cis rs55871839 0.708 rs6651298 chr8:59808307 C/G cg07426533 chr8:59803705 TOX -0.35 -6.24 -0.33 1.36e-9 Pneumonia; CRC cis rs8103278 0.826 rs11669442 chr19:46374557 A/G cg14061069 chr19:46274453 DMPK -0.45 -6.56 -0.34 2.04e-10 Coronary artery disease; CRC cis rs7666738 0.830 rs4323111 chr4:98952276 A/G cg17366294 chr4:99064904 C4orf37 0.43 7.22 0.37 3.66e-12 Colonoscopy-negative controls vs population controls; CRC cis rs7208859 0.673 rs7211776 chr17:29120196 T/G cg13385521 chr17:29058706 SUZ12P 0.57 7.29 0.37 2.29e-12 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs12541635 0.966 rs2132471 chr8:107000963 G/A cg10147462 chr8:107024639 NA 0.42 6.99 0.36 1.49e-11 Age of smoking initiation; CRC cis rs3806843 1.000 rs12717860 chr5:140171442 C/T cg19875535 chr5:140030758 IK 0.61 9.83 0.48 3.58e-20 Depressive symptoms (multi-trait analysis); CRC cis rs870825 1.000 rs870825 chr4:185588045 A/G cg04058563 chr4:185651563 MLF1IP 0.67 7.0 0.36 1.41e-11 Blood protein levels; CRC trans rs2303319 0.504 rs62187612 chr2:162432494 A/G cg04269497 chr6:167369491 RNASET2 -0.75 -5.99 -0.31 5.54e-9 Cognitive function; CRC cis rs875971 0.508 rs10253883 chr7:66061138 T/C cg11764359 chr7:65958608 NA -0.5 -7.75 -0.39 1.14e-13 Aortic root size; CRC cis rs780096 0.526 rs780107 chr2:27684734 A/G cg22903471 chr2:27725779 GCKR -0.37 -6.06 -0.32 3.65e-9 Total body bone mineral density; CRC cis rs9309473 0.748 rs2421552 chr2:73758803 C/T cg20560298 chr2:73613845 ALMS1 -0.5 -6.12 -0.32 2.7e-9 Metabolite levels; CRC cis rs7208859 0.673 rs999798 chr17:29158840 A/G cg01831904 chr17:28903510 LRRC37B2 -0.48 -5.85 -0.31 1.2e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs9549367 0.713 rs2480949 chr13:113853149 T/C cg24300038 chr13:113819356 PROZ 0.51 6.69 0.35 9.53e-11 Platelet distribution width; CRC cis rs10464366 0.544 rs4540324 chr7:39185299 G/C cg18850127 chr7:39170497 POU6F2 0.57 7.56 0.38 4e-13 IgG glycosylation; CRC trans rs9858542 0.953 rs9862080 chr3:49674458 A/G cg21659725 chr3:3221576 CRBN -0.73 -9.61 -0.47 1.99e-19 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs889312 0.500 rs3099460 chr5:56133748 G/C cg24531977 chr5:56204891 C5orf35 -0.45 -6.83 -0.35 4e-11 Breast cancer;Breast cancer (early onset); CRC cis rs875971 1.000 rs10215948 chr7:65747786 G/A cg00343986 chr7:65444356 GUSB -0.44 -6.42 -0.33 4.74e-10 Aortic root size; CRC cis rs8062405 0.721 rs151303 chr16:28492510 C/A cg16576597 chr16:28551801 NUPR1 0.46 6.44 0.33 4.28e-10 Cognitive ability (multi-trait analysis);Cognitive ability; CRC cis rs6502050 0.835 rs34287733 chr17:80078236 C/T cg25804541 chr17:80189381 SLC16A3 0.3 5.78 0.3 1.69e-8 Life satisfaction; CRC cis rs6570726 0.846 rs439035 chr6:145887990 G/C cg13319975 chr6:146136371 FBXO30 -0.39 -5.86 -0.31 1.13e-8 Lobe attachment (rater-scored or self-reported); CRC trans rs4352210 0.963 rs7589042 chr2:37761495 C/T cg13134662 chr9:136858680 VAV2 -0.41 -6.01 -0.31 4.89e-9 RR interval (heart rate); CRC cis rs9325144 0.581 rs6582564 chr12:38671282 G/A cg26384229 chr12:38710491 ALG10B -0.51 -7.56 -0.38 4.13e-13 Morning vs. evening chronotype; CRC cis rs501120 0.584 rs61857482 chr10:44716905 C/T cg09554077 chr10:44749378 NA 0.65 7.29 0.37 2.37e-12 Coronary artery disease;Coronary heart disease; CRC cis rs10463316 0.832 rs246486 chr5:150727880 C/T cg03212797 chr5:150827313 SLC36A1 0.46 7.14 0.37 5.85e-12 Metabolite levels (Pyroglutamine); CRC cis rs26868 0.742 rs26848 chr16:2263516 A/G cg02248941 chr16:2239361 CASKIN1 0.68 13.44 0.6 4.03e-33 Height; CRC cis rs9527 0.590 rs7912517 chr10:104905529 G/A cg04362960 chr10:104952993 NT5C2 0.6 8.36 0.42 1.74e-15 Arsenic metabolism; CRC cis rs4561483 0.549 rs33659 chr16:11963361 A/G cg08843971 chr16:11963173 GSPT1 -0.48 -7.63 -0.39 2.58e-13 Testicular germ cell tumor; CRC cis rs13118159 0.742 rs34947293 chr4:1335034 T/C cg20887711 chr4:1340912 KIAA1530 0.42 5.9 0.31 8.85e-9 Longevity; CRC cis rs7703051 0.520 rs13354746 chr5:74619132 C/T cg19683494 chr5:74908142 NA 0.56 7.31 0.37 2.05e-12 LDL cholesterol;Age-related disease endophenotypes;Age-related diseases, mortality and associated endophenotypes; CRC cis rs2880765 0.835 rs4843063 chr15:86048748 G/T cg17133734 chr15:86042851 AKAP13 0.42 6.86 0.35 3.32e-11 Coronary artery disease; CRC cis rs12681287 0.640 rs67123356 chr8:87453992 A/C cg27223183 chr8:87520930 FAM82B -0.52 -7.42 -0.38 9.82e-13 Caudate activity during reward; CRC cis rs10463316 0.817 rs10052992 chr5:150788602 C/T cg03212797 chr5:150827313 SLC36A1 -0.4 -6.26 -0.33 1.23e-9 Metabolite levels (Pyroglutamine); CRC cis rs780096 0.526 rs13391837 chr2:27649375 A/G cg12648201 chr2:27665141 KRTCAP3 -0.31 -6.1 -0.32 3.05e-9 Total body bone mineral density; CRC cis rs9400271 0.632 rs9384706 chr6:109601504 C/T cg01475377 chr6:109611718 NA -0.36 -6.24 -0.33 1.34e-9 Sum neutrophil eosinophil counts;Sum basophil neutrophil counts;White blood cell count;Neutrophil count;Myeloid white cell count;Granulocyte count; CRC cis rs7666738 0.830 rs6811940 chr4:98777898 G/A cg05340658 chr4:99064831 C4orf37 0.55 8.16 0.41 7.26e-15 Colonoscopy-negative controls vs population controls; CRC cis rs9894429 0.789 rs9747336 chr17:79584189 C/T cg21028142 chr17:79581711 NPLOC4 0.33 6.96 0.36 1.81e-11 Eye color traits; CRC cis rs1552244 0.882 rs34706481 chr3:10004123 G/A cg13047869 chr3:10149882 C3orf24 0.51 6.52 0.34 2.67e-10 Alzheimer's disease; CRC cis rs6963495 0.818 rs6973263 chr7:105170293 A/G cg02135003 chr7:105160482 PUS7 -0.92 -12.46 -0.57 1.94e-29 Bipolar disorder (body mass index interaction); CRC cis rs4689388 0.816 rs13147655 chr4:6293474 A/G cg00701064 chr4:6280414 WFS1 0.75 13.11 0.59 7.27e-32 Type 2 diabetes and other traits;Type 2 diabetes; CRC cis rs1448094 0.512 rs12314274 chr12:86249196 A/G cg18827107 chr12:86230957 RASSF9 -0.46 -7.72 -0.39 1.42e-13 Major depressive disorder; CRC cis rs7843479 0.601 rs2306646 chr8:21846586 C/G cg16476235 chr8:21771668 DOK2 0.42 7.35 0.38 1.6e-12 Mean corpuscular volume; CRC cis rs9486719 0.843 rs3860231 chr6:97036563 G/A cg18709589 chr6:96969512 KIAA0776 -0.46 -5.93 -0.31 7.72e-9 Migraine;Coronary artery disease; CRC cis rs853679 0.517 rs9468286 chr6:28079428 C/T cg15786705 chr6:28176104 NA 0.76 9.47 0.46 5.57e-19 Depression; CRC cis rs372883 0.600 rs2832293 chr21:30738872 C/G cg24692254 chr21:30365293 RNF160 0.65 9.84 0.48 3.51e-20 Pancreatic cancer; CRC cis rs172166 0.538 rs1150686 chr6:28161271 T/G cg02683197 chr6:28174875 NA 0.48 6.72 0.35 8e-11 Cardiac Troponin-T levels; CRC cis rs7617773 0.823 rs9839447 chr3:48194667 T/C cg11946769 chr3:48343235 NME6 -0.51 -6.83 -0.35 4.12e-11 Coronary artery disease; CRC trans rs2303319 0.504 rs35304298 chr2:162617185 G/T cg27342122 chr8:133787442 PHF20L1 -0.72 -6.09 -0.32 3.2e-9 Cognitive function; CRC cis rs12701220 0.553 rs13245507 chr7:1163694 C/T cg00990874 chr7:1149470 C7orf50 -0.6 -7.47 -0.38 7.42e-13 Bronchopulmonary dysplasia; CRC cis rs3771570 1.000 rs56052835 chr2:242243251 T/G cg21155796 chr2:242212141 HDLBP 0.64 7.0 0.36 1.48e-11 Prostate cancer; CRC cis rs10791323 0.628 rs2851118 chr11:133705995 A/C cg06766960 chr11:133703094 NA -0.36 -6.1 -0.32 2.92e-9 Childhood ear infection; CRC cis rs9814567 1.000 rs1917130 chr3:134313773 G/A cg06109529 chr3:134205091 CEP63;ANAPC13 0.82 11.89 0.55 2.31e-27 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs10256972 0.577 rs2949179 chr7:1209885 C/G cg18765753 chr7:1198926 ZFAND2A -0.52 -9.55 -0.47 3.19e-19 Longevity;Endometriosis; CRC cis rs968567 0.906 rs61897793 chr11:61599347 G/A cg10868875 chr11:61596307 FADS2 -0.53 -6.36 -0.33 6.8e-10 Blood metabolite levels;Rheumatoid arthritis;Vitiligo;Glycerophospholipid levels; CRC cis rs10504229 0.639 rs67996345 chr8:58117127 A/G cg02725872 chr8:58115012 NA -0.64 -11.55 -0.54 3.85e-26 Developmental language disorder (linguistic errors); CRC cis rs2549003 1.000 rs2549005 chr5:131827191 C/T cg21138405 chr5:131827807 IRF1 0.58 11.34 0.53 2.23e-25 Asthma (sex interaction); CRC cis rs7044106 0.762 rs1158553 chr9:123400974 C/G cg09586646 chr9:123605570 PSMD5;LOC253039 0.62 8.77 0.44 9.87e-17 Hip circumference adjusted for BMI; CRC cis rs7623687 1.000 rs7623687 chr3:49448566 A/C cg19401529 chr3:49056140 DALRD3 0.53 6.05 0.32 3.92e-9 Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease);Coronary artery disease; CRC cis rs7208859 0.673 rs11657270 chr17:29214387 A/G cg01831904 chr17:28903510 LRRC37B2 -0.55 -5.82 -0.31 1.42e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs7580658 0.750 rs6731176 chr2:128071003 C/T cg09760422 chr2:128146352 NA -0.32 -6.22 -0.32 1.52e-9 Protein C levels; CRC cis rs2404602 0.684 rs8029283 chr15:76837140 A/G cg23625390 chr15:77176239 SCAPER -0.87 -14.65 -0.63 9.13e-38 Blood metabolite levels; CRC cis rs6582630 0.555 rs7965311 chr12:38513307 G/A cg13010199 chr12:38710504 ALG10B -0.47 -6.78 -0.35 5.52e-11 Drug-induced liver injury (flucloxacillin); CRC cis rs4722166 0.630 rs12537614 chr7:22789551 C/G cg26061582 chr7:22766209 IL6 0.52 7.92 0.4 3.8e-14 Lung cancer; CRC cis rs1552244 0.872 rs6771931 chr3:10113408 C/G cg02579736 chr3:10068473 FANCD2;CIDECP 0.96 12.92 0.58 3.51e-31 Alzheimer's disease; CRC cis rs1552244 0.808 rs17032306 chr3:10091399 C/G cg18598329 chr3:10140678 FANCD2;C3orf24 -0.89 -12.69 -0.57 2.6e-30 Alzheimer's disease; CRC cis rs9443645 0.901 rs9448590 chr6:79606429 C/G cg09184832 chr6:79620586 NA -0.52 -9.73 -0.47 7.62e-20 Intelligence (multi-trait analysis); CRC cis rs751728 1.000 rs2395449 chr6:33728755 T/A cg25922239 chr6:33757077 LEMD2 0.6 8.78 0.44 9.2e-17 Crohn's disease; CRC cis rs208520 0.754 rs7753158 chr6:66875633 A/C cg07460842 chr6:66804631 NA -0.97 -12.68 -0.57 2.93e-30 Exhaled nitric oxide output; CRC cis rs35110281 0.633 rs2329593 chr21:45121987 T/C cg01579765 chr21:45077557 HSF2BP -0.34 -6.25 -0.33 1.29e-9 Mean corpuscular volume; CRC cis rs9611565 0.649 rs202657 chr22:41844786 G/T cg03806693 chr22:41940476 POLR3H 1.12 14.43 0.62 6.27e-37 Vitiligo; CRC cis rs755249 0.567 rs16825942 chr1:39662618 G/A cg18385671 chr1:39797026 MACF1 -0.41 -5.93 -0.31 7.46e-9 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs2243480 0.803 rs35480979 chr7:65357084 A/G cg12463550 chr7:65579703 CRCP 0.66 6.14 0.32 2.36e-9 Diabetic kidney disease; CRC cis rs9359856 0.636 rs1179896 chr6:90318610 T/C cg13799429 chr6:90582589 CASP8AP2 -0.61 -8.25 -0.41 3.78e-15 Bipolar disorder; CRC cis rs7666738 0.830 rs1426666 chr4:99030887 A/G cg05340658 chr4:99064831 C4orf37 0.61 9.42 0.46 8.23e-19 Colonoscopy-negative controls vs population controls; CRC trans rs61931739 0.500 rs11053199 chr12:34450534 C/T cg26384229 chr12:38710491 ALG10B -0.6 -8.79 -0.44 8.6e-17 Morning vs. evening chronotype; CRC cis rs17234274 0.607 rs1482712 chr11:23218177 G/T cg05245346 chr11:23248277 NA 0.36 5.92 0.31 8.22e-9 Cancer; CRC cis rs7589728 1.000 rs75309929 chr2:88524377 T/C cg07952391 chr2:88470173 THNSL2 0.66 6.66 0.34 1.15e-10 Plasma clusterin levels; CRC cis rs56399783 0.901 rs17132624 chr7:2778496 G/A cg23627948 chr7:2760692 NA 0.47 5.62 0.3 3.98e-8 Childhood ear infection; CRC cis rs1552244 1.000 rs6804473 chr3:10060425 C/T cg13047869 chr3:10149882 C3orf24 0.52 7.07 0.36 9.6e-12 Alzheimer's disease; CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg10047026 chr17:4613992 ARRB2 0.37 6.21 0.32 1.62e-9 Obesity-related traits; CRC cis rs9583531 0.891 rs9521911 chr13:111370615 A/G cg24331049 chr13:111365604 ING1 -0.62 -6.66 -0.34 1.14e-10 Coronary artery disease; CRC cis rs7618501 0.699 rs2777888 chr3:49898000 A/G cg24110177 chr3:50126178 RBM5 -0.45 -6.59 -0.34 1.75e-10 Intelligence (multi-trait analysis); CRC cis rs1218582 0.772 rs10796935 chr1:154891363 G/T cg24250549 chr1:154909240 PMVK 0.65 11.35 0.53 1.97e-25 Prostate cancer; CRC cis rs6754311 0.773 rs309178 chr2:136611624 C/T cg25344623 chr2:136566232 LCT 0.33 5.98 0.31 5.97e-9 Mosquito bite size; CRC cis rs6694672 1.000 rs4915313 chr1:197049355 G/T cg13682187 chr1:196946512 CFHR5 0.42 6.81 0.35 4.73e-11 Asthma; CRC cis rs12893668 0.543 rs1799796 chr14:104165927 T/C cg01849466 chr14:104193079 ZFYVE21 -0.42 -6.19 -0.32 1.83e-9 Reticulocyte count; CRC cis rs2327429 0.541 rs12193973 chr6:134151297 A/G cg06643013 chr6:134217242 NA -0.39 -6.35 -0.33 7.15e-10 Coronary artery disease; CRC cis rs9733 0.519 rs11800855 chr1:150800995 G/A cg17724175 chr1:150552817 MCL1 0.43 6.6 0.34 1.63e-10 Tonsillectomy; CRC cis rs6540556 0.723 rs1999826 chr1:209919275 C/T cg23920097 chr1:209922102 NA -0.54 -6.69 -0.35 9.65e-11 Red blood cell count; CRC cis rs4363385 0.574 rs6683514 chr1:152984397 A/G cg25856811 chr1:152973957 SPRR3 -0.22 -5.96 -0.31 6.65e-9 Inflammatory skin disease; CRC cis rs9457247 0.765 rs1322077 chr6:167424293 T/C cg23791538 chr6:167370224 RNASET2 -0.4 -5.98 -0.31 5.7e-9 Crohn's disease; CRC cis rs1005277 0.579 rs116912400 chr10:38479207 G/T cg17219203 chr10:38645113 HSD17B7P2 -0.4 -5.61 -0.3 4.37e-8 Extrinsic epigenetic age acceleration; CRC cis rs7119 0.717 rs62009069 chr15:77817877 T/G cg27398640 chr15:77910606 LINGO1 -0.43 -7.47 -0.38 7.13e-13 Type 2 diabetes; CRC cis rs1023500 0.573 rs133370 chr22:42465260 T/C cg25452165 chr22:42524984 CYP2D6 0.39 5.99 0.31 5.38e-9 Schizophrenia; CRC cis rs4563143 0.634 rs113736470 chr19:29240125 G/A cg12756686 chr19:29218302 NA 0.66 10.26 0.49 1.28e-21 Methadone dose in opioid dependence; CRC cis rs4713118 0.869 rs6930992 chr6:27712120 A/C cg15845792 chr6:28175446 NA 0.65 9.11 0.45 7.98e-18 Parkinson's disease; CRC cis rs2882667 0.690 rs9327830 chr5:138272249 T/C cg09476006 chr5:138032270 NA 0.58 10.03 0.48 7.68e-21 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs9291683 0.679 rs2241483 chr4:10099831 A/G cg00071950 chr4:10020882 SLC2A9 -0.51 -8.98 -0.44 2.14e-17 Bone mineral density; CRC cis rs4988958 0.565 rs6760621 chr2:102999952 T/C cg03938978 chr2:103052716 IL18RAP 0.59 10.12 0.49 3.77e-21 Asthma (childhood onset); CRC cis rs853679 0.517 rs2275508 chr6:28094731 T/C cg18032046 chr6:28092343 ZSCAN16 -0.5 -5.89 -0.31 9.29e-9 Depression; CRC trans rs2732480 0.577 rs2634681 chr12:48733084 C/T cg10075436 chr19:59084928 MZF1;LOC100131691 -0.45 -6.01 -0.31 4.84e-9 Hemoglobin concentration;Red blood cell count;Hematocrit; CRC cis rs11098499 0.619 rs28502463 chr4:120257023 T/C cg24375607 chr4:120327624 NA 0.47 7.47 0.38 7.33e-13 Corneal astigmatism; CRC cis rs919433 0.648 rs787975 chr2:198248128 C/T cg10820045 chr2:198174542 NA 0.41 6.93 0.36 2.2e-11 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC cis rs7552404 1.000 rs1498312 chr1:76177849 C/T cg10523679 chr1:76189770 ACADM 0.85 11.59 0.54 2.91e-26 Blood metabolite levels;Acylcarnitine levels; CRC cis rs9818758 0.607 rs9990153 chr3:49291883 C/T cg00383909 chr3:49044727 WDR6 1.1 10.53 0.5 1.49e-22 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; CRC cis rs7259376 0.902 rs8100087 chr19:22601359 G/C cg02657401 chr19:22469223 NA 0.31 6.65 0.34 1.23e-10 Menopause (age at onset); CRC cis rs997295 0.570 rs11632574 chr15:67852405 A/C cg24247231 chr15:67904302 MAP2K5 -0.34 -5.96 -0.31 6.63e-9 Motion sickness; CRC cis rs9311474 0.508 rs11720243 chr3:52618018 T/C cg10802521 chr3:52805072 NEK4 -0.57 -9.04 -0.45 1.41e-17 Electroencephalogram traits; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg03586379 chr3:140660603 SLC25A36 -0.42 -6.31 -0.33 9.06e-10 Myopia (pathological); CRC cis rs12541635 0.902 rs13277300 chr8:107062819 C/T cg10147462 chr8:107024639 NA -0.39 -6.64 -0.34 1.3e-10 Age of smoking initiation; CRC cis rs4332037 0.539 rs11764780 chr7:2020904 G/C cg23422044 chr7:1970798 MAD1L1 -0.61 -7.48 -0.38 6.75e-13 Bipolar disorder; CRC cis rs6674176 0.660 rs11210936 chr1:44391438 A/T cg12908607 chr1:44402522 ARTN -0.6 -11.08 -0.52 1.8e-24 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Cognitive ability; CRC trans rs8002861 0.664 rs2325089 chr13:44450222 C/G cg12856521 chr11:46389249 DGKZ -0.42 -6.92 -0.36 2.33e-11 Leprosy; CRC cis rs4862750 0.914 rs1991255 chr4:187875340 G/A cg03647317 chr4:187891568 NA -0.55 -10.27 -0.49 1.19e-21 Lobe attachment (rater-scored or self-reported); CRC cis rs4665809 0.618 rs7579199 chr2:26266496 G/A cg22920501 chr2:26401640 FAM59B -0.52 -7.08 -0.36 8.91e-12 Gut microbiome composition (summer); CRC cis rs853679 0.517 rs1904840 chr6:28108232 C/T cg12172441 chr6:28176163 NA 0.64 7.53 0.38 5.03e-13 Depression; CRC cis rs7618501 0.602 rs2301166 chr3:50148305 C/G cg24110177 chr3:50126178 RBM5 0.52 8.16 0.41 7.29e-15 Intelligence (multi-trait analysis); CRC cis rs270601 0.770 rs932019 chr5:131599370 T/C cg01305625 chr5:131593812 PDLIM4 0.32 5.66 0.3 3.34e-8 Acylcarnitine levels; CRC cis rs7772486 0.754 rs4896838 chr6:146015451 T/C cg05347473 chr6:146136440 FBXO30 -0.42 -6.18 -0.32 1.87e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs853679 0.517 rs35193936 chr6:28076270 A/G cg06470822 chr6:28175283 NA 1.0 13.33 0.59 1.04e-32 Depression; CRC trans rs2211560 0.507 rs677669 chr1:61287632 A/C cg21640187 chr6:4282172 NA 0.3 6.04 0.32 4.28e-9 Facial morphology (factor 12, vertical position of sublabial sulcus relative to central midface); CRC cis rs4665809 0.627 rs7562192 chr2:26469457 C/G cg25036284 chr2:26402008 FAM59B 0.66 8.74 0.43 1.21e-16 Gut microbiome composition (summer); CRC cis rs10416265 0.528 rs7249097 chr19:33589144 T/C cg27124370 chr19:33622961 WDR88 0.47 6.88 0.35 2.94e-11 Bone properties (heel); CRC cis rs763014 0.932 rs2269559 chr16:682297 T/C cg08989290 chr16:615782 NHLRC4 0.48 9.14 0.45 6.5e-18 Height; CRC cis rs28493229 0.522 rs2287692 chr19:41289756 G/A cg21869046 chr19:41225005 ITPKC 0.6 8.23 0.41 4.47e-15 Kawasaki disease; CRC cis rs6693567 0.565 rs834243 chr1:150339290 C/A cg15654264 chr1:150340011 RPRD2 0.38 5.95 0.31 7.02e-9 Migraine; CRC cis rs6500395 1.000 rs3848321 chr16:48620780 A/T cg04672837 chr16:48644449 N4BP1 0.44 6.6 0.34 1.69e-10 Response to tocilizumab in rheumatoid arthritis; CRC cis rs370915 0.549 rs1367933 chr4:187776591 C/T cg12892747 chr4:187813459 NA -0.56 -8.12 -0.41 9.57e-15 Gout; CRC cis rs7618501 0.602 rs9311446 chr3:50092226 G/A cg05623727 chr3:50126028 RBM5 -0.46 -7.62 -0.39 2.67e-13 Intelligence (multi-trait analysis); CRC cis rs11098499 0.955 rs1511015 chr4:120170473 A/C cg24375607 chr4:120327624 NA 0.44 6.82 0.35 4.49e-11 Corneal astigmatism; CRC cis rs11214589 0.651 rs11214596 chr11:113264511 C/G cg14159747 chr11:113255604 NA 0.62 12.55 0.57 9.05e-30 Neuroticism; CRC cis rs4481887 0.800 rs10888342 chr1:248441999 A/G cg13385794 chr1:248469461 NA 0.39 6.86 0.35 3.32e-11 Common traits (Other); CRC cis rs9649465 1.000 rs10215466 chr7:123326044 G/T cg03229431 chr7:123269106 ASB15 -0.36 -5.64 -0.3 3.7e-8 Migraine; CRC cis rs7191439 0.858 rs11076702 chr16:88774569 A/C cg02389323 chr16:88786976 FAM38A 1.07 9.18 0.45 4.96e-18 Plateletcrit; CRC cis rs10089 1.000 rs4836369 chr5:127486462 A/G cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.74 10.4 0.5 4.25e-22 Ileal carcinoids; CRC cis rs10849893 0.557 rs6489812 chr12:121913559 T/A cg01154721 chr12:121881891 KDM2B 0.44 6.19 0.32 1.81e-9 Fasting blood glucose;Fasting blood glucose (BMI interaction); CRC cis rs1552244 1.000 rs722509 chr3:10102377 T/A cg08888203 chr3:10149979 C3orf24 0.73 10.16 0.49 2.86e-21 Alzheimer's disease; CRC cis rs1800795 0.530 rs7805828 chr7:22758562 A/G cg05472934 chr7:22766657 IL6 -0.43 -6.21 -0.32 1.57e-9 Cerebrospinal fluid clusterin levels in APOEe4- carriers; CRC cis rs1816752 0.935 rs3816219 chr13:25017133 C/T cg02811702 chr13:24901961 NA 0.49 6.64 0.34 1.29e-10 Obesity-related traits; CRC cis rs6456156 0.766 rs150112 chr6:167509878 C/T cg07741184 chr6:167504864 NA -0.39 -6.6 -0.34 1.61e-10 Primary biliary cholangitis; CRC cis rs12745968 0.590 rs2391195 chr1:93218683 A/G cg17283838 chr1:93427260 FAM69A -0.44 -6.05 -0.32 3.98e-9 Bipolar disorder and schizophrenia; CRC cis rs116095464 0.558 rs61689490 chr5:224904 T/C cg22857025 chr5:266934 NA -1.22 -16.66 -0.68 1.26e-45 Breast cancer; CRC cis rs1218582 0.772 rs4845694 chr1:154911651 C/G cg06221963 chr1:154839813 KCNN3 -0.75 -14.96 -0.64 5.75e-39 Prostate cancer; CRC cis rs6952808 0.792 rs2056478 chr7:1953897 C/T cg00106254 chr7:1943704 MAD1L1 -0.52 -7.7 -0.39 1.56e-13 Bipolar disorder and schizophrenia; CRC cis rs2290159 0.800 rs11709504 chr3:12674199 T/C cg23032965 chr3:12705835 RAF1 0.47 6.38 0.33 6.16e-10 Cholesterol, total; CRC cis rs7493 1.000 rs7786401 chr7:95034001 G/T cg20119798 chr7:94954144 PON1 -0.5 -6.41 -0.33 5.17e-10 Yu-Zhi constitution type in type 2 diabetes; CRC trans rs4332037 0.539 rs56305291 chr7:2048706 A/G cg11693508 chr17:37793320 STARD3 0.61 7.03 0.36 1.23e-11 Bipolar disorder; CRC cis rs12497850 1.000 rs4858798 chr3:48727112 C/T cg20833759 chr3:49053208 WDR6;DALRD3 0.44 7.49 0.38 6.27e-13 Parkinson's disease; CRC cis rs8060686 0.920 rs55661503 chr16:67836552 T/A cg26727032 chr16:67993705 SLC12A4 -0.59 -7.12 -0.37 7.02e-12 HDL cholesterol;Metabolic syndrome; CRC cis rs7149337 0.804 rs4131981 chr14:51667504 A/T cg23942311 chr14:51606299 NA -0.74 -13.44 -0.6 3.86e-33 Cancer; CRC cis rs8180040 0.903 rs2276853 chr3:47282303 G/A cg27129171 chr3:47204927 SETD2 0.72 12.03 0.55 7.11e-28 Colorectal cancer; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg01145398 chr10:135075451 NA -0.4 -6.0 -0.31 5.22e-9 Myopia (pathological); CRC cis rs6582630 0.599 rs1851114 chr12:38424671 C/T cg26384229 chr12:38710491 ALG10B -0.53 -7.57 -0.38 3.88e-13 Drug-induced liver injury (flucloxacillin); CRC cis rs911555 0.723 rs11160751 chr14:103925740 T/C cg12935359 chr14:103987150 CKB -0.54 -8.93 -0.44 3.1e-17 Intelligence (multi-trait analysis); CRC cis rs2032447 1.000 rs2032447 chr6:26044369 A/G cg12588279 chr6:26043732 HIST1H2BB 0.44 6.67 0.35 1.06e-10 Intelligence (multi-trait analysis); CRC cis rs1057239 0.739 rs1014554 chr1:175133626 A/G cg14847009 chr1:175162515 KIAA0040 0.3 6.67 0.34 1.11e-10 Diastolic blood pressure; CRC cis rs2506889 0.553 rs17035189 chr1:10597024 A/G cg17425144 chr1:10567563 PEX14 0.53 12.15 0.56 2.66e-28 Breast cancer; CRC cis rs6951245 0.872 rs76161580 chr7:1100307 G/T cg21664854 chr7:1097933 C7orf50;GPR146 0.77 8.8 0.44 7.85e-17 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs2404602 1.000 rs2404740 chr15:76852143 C/T cg03037974 chr15:76606532 NA 0.65 11.09 0.52 1.77e-24 Blood metabolite levels; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg21151883 chr4:7044737 CCDC96;TADA2B 0.39 5.99 0.31 5.42e-9 Intelligence (multi-trait analysis); CRC cis rs910316 0.763 rs175044 chr14:75472109 G/A cg08847533 chr14:75593920 NEK9 -0.86 -14.68 -0.63 7.22e-38 Height; CRC cis rs2760061 0.598 rs590657 chr1:228117581 A/C cg02753203 chr1:228287806 NA -0.61 -8.96 -0.44 2.43e-17 Diastolic blood pressure; CRC cis rs7568458 0.811 rs10175792 chr2:85761654 A/G cg02493740 chr2:85810744 VAMP5 -0.39 -6.15 -0.32 2.21e-9 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); CRC cis rs17443541 0.507 rs6753800 chr2:200462959 G/C cg03741458 chr2:200468445 NA -0.37 -5.85 -0.31 1.18e-8 Intelligence (multi-trait analysis); CRC cis rs7849270 1.000 rs713219 chr9:131900920 T/C cg13538475 chr9:131942899 NA -0.33 -6.32 -0.33 8.52e-10 Blood metabolite ratios; CRC trans rs11098499 0.866 rs72676074 chr4:120359841 A/C cg25214090 chr10:38739885 LOC399744 0.66 10.5 0.5 2.02e-22 Corneal astigmatism; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg20908614 chr3:130613463 ATP2C1 0.42 6.05 0.32 3.84e-9 Intelligence (multi-trait analysis); CRC cis rs826838 0.935 rs11169508 chr12:39173385 C/T cg26384229 chr12:38710491 ALG10B 0.7 9.88 0.48 2.51e-20 Heart rate; CRC cis rs9462027 0.628 rs9469892 chr6:34769101 T/C cg07306190 chr6:34760872 UHRF1BP1 -0.34 -6.06 -0.32 3.75e-9 Systemic lupus erythematosus; CRC cis rs9560113 1.000 rs9560104 chr13:112174389 A/G cg10483660 chr13:112241077 NA 0.35 5.62 0.3 4.14e-8 Menarche (age at onset); CRC cis rs12887734 0.566 rs3742366 chr14:104198351 T/C cg01849466 chr14:104193079 ZFYVE21 -0.46 -7.01 -0.36 1.32e-11 Schizophrenia;Autism spectrum disorder or schizophrenia; CRC cis rs6693567 0.565 rs698917 chr1:150319884 G/A cg04165759 chr1:150448943 RPRD2 0.36 5.85 0.31 1.18e-8 Migraine; CRC cis rs6694672 0.867 rs7523013 chr1:197153188 A/G cg13682187 chr1:196946512 CFHR5 0.52 7.88 0.4 4.81e-14 Asthma; CRC cis rs798554 0.567 rs1182194 chr7:2868824 C/G cg13628971 chr7:2884303 GNA12 0.39 6.07 0.32 3.51e-9 Height; CRC cis rs4713118 0.699 rs573179 chr6:27849676 C/A cg10876282 chr6:28092338 ZSCAN16 0.47 5.74 0.3 2.12e-8 Parkinson's disease; CRC cis rs34816374 1 rs34816374 chr6:26949672 A/G cg16898833 chr6:26189333 HIST1H4D 0.87 6.41 0.33 5.05e-10 Lung cancer in ever smokers; CRC cis rs2795502 1.000 rs2744090 chr10:43339614 G/C cg20628663 chr10:43360327 NA -0.69 -10.81 -0.51 1.67e-23 Blood protein levels; CRC cis rs9443645 0.527 rs1415859 chr6:79794858 A/G cg09184832 chr6:79620586 NA -0.44 -7.39 -0.38 1.19e-12 Intelligence (multi-trait analysis); CRC cis rs3796352 1.000 rs36090694 chr3:53010742 T/C cg06204229 chr3:52865917 ITIH4 0.49 5.7 0.3 2.61e-8 Immune reponse to smallpox (secreted IL-2); CRC cis rs10504229 0.636 rs117439064 chr8:58055279 A/G cg11062466 chr8:58055876 NA 0.55 6.76 0.35 6.4e-11 Developmental language disorder (linguistic errors); CRC cis rs523522 0.962 rs655530 chr12:121022275 T/C cg12219531 chr12:120966889 COQ5 0.69 9.12 0.45 7.92e-18 High light scatter reticulocyte count; CRC cis rs2576037 0.526 rs10853545 chr18:44475220 A/T cg19077165 chr18:44547161 KATNAL2 -0.56 -9.37 -0.46 1.24e-18 Personality dimensions; CRC cis rs6088590 0.965 rs6058108 chr20:33288655 A/G cg08999081 chr20:33150536 PIGU 0.5 8.54 0.43 4.95e-16 Coronary artery disease; CRC trans rs208520 0.690 rs207119 chr6:66786408 C/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.08 -15.36 -0.65 1.56e-40 Exhaled nitric oxide output; CRC cis rs10751667 0.666 rs4074233 chr11:977685 G/A cg06064525 chr11:970664 AP2A2 -0.3 -6.11 -0.32 2.78e-9 Alzheimer's disease (late onset); CRC cis rs9796 0.745 rs2947493 chr15:41375694 G/A cg18705301 chr15:41695430 NDUFAF1 -0.38 -6.42 -0.33 4.69e-10 Menopause (age at onset); CRC cis rs1577917 0.655 rs2842600 chr6:86325632 C/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.49 -6.78 -0.35 5.7e-11 Response to antipsychotic treatment; CRC cis rs4654899 0.758 rs4457549 chr1:21487231 A/G cg02927042 chr1:21476669 EIF4G3 0.41 6.47 0.34 3.62e-10 Superior frontal gyrus grey matter volume; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg19936585 chr2:139259770 SPOPL 0.38 6.1 0.32 2.9e-9 Liver disease severity in Alagille syndrome; CRC cis rs1153858 1.000 rs16952714 chr15:45650358 G/A cg10760299 chr15:45669010 GATM 0.5 8.03 0.41 1.7e-14 Homoarginine levels; CRC cis rs4363385 0.818 rs3181787 chr1:153004809 T/C cg25856811 chr1:152973957 SPRR3 -0.25 -6.97 -0.36 1.7e-11 Inflammatory skin disease; CRC cis rs4713118 0.527 rs36042294 chr6:27720712 C/G cg15845792 chr6:28175446 NA 0.58 8.25 0.41 3.8e-15 Parkinson's disease; CRC cis rs908922 0.676 rs6587681 chr1:152512135 C/T cg23254163 chr1:152506842 NA 0.45 8.85 0.44 5.3e-17 Hair morphology; CRC cis rs546131 0.928 rs483976 chr11:34840167 C/G cg24088639 chr11:34937564 PDHX;APIP -0.43 -6.01 -0.31 4.88e-9 Lung disease severity in cystic fibrosis; CRC cis rs7917772 0.503 rs11191326 chr10:104302959 C/T cg11453585 chr10:104263688 ACTR1A;SUFU 0.91 17.49 0.69 6.57e-49 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC cis rs2985684 1.000 rs8014170 chr14:50071694 C/G cg23565292 chr14:50234668 KLHDC2 -0.42 -5.84 -0.31 1.23e-8 Carotid intima media thickness; CRC cis rs6570726 0.526 rs4896805 chr6:145735429 C/A cg23711669 chr6:146136114 FBXO30 -0.48 -7.8 -0.4 8.12e-14 Lobe attachment (rater-scored or self-reported); CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg08806622 chr17:27279525 PHF12 0.4 6.45 0.34 3.92e-10 Obesity-related traits; CRC cis rs1539053 0.932 rs1404384 chr1:58109829 A/G cg20292791 chr1:58089357 DAB1 0.36 6.22 0.32 1.52e-9 Plasma omega-6 polyunsaturated fatty acid levels (arachidonic acid); CRC cis rs3026101 0.671 rs9789012 chr17:5301070 C/G cg25236894 chr17:5323110 RPAIN;NUP88 0.42 6.9 0.36 2.74e-11 Body mass index; CRC cis rs7584330 0.868 rs2325839 chr2:238386286 T/C cg11271282 chr2:238384023 NA 0.46 6.01 0.31 4.99e-9 Prostate cancer; CRC cis rs7208859 0.623 rs7217984 chr17:29092766 G/A cg01831904 chr17:28903510 LRRC37B2 -0.63 -6.53 -0.34 2.51e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs1451375 0.657 rs7802148 chr7:50648284 T/C cg18232548 chr7:50535776 DDC 0.44 6.25 0.33 1.24e-9 Malaria; CRC cis rs9435341 0.965 rs3108680 chr1:107572997 T/C cg14828511 chr1:107599125 PRMT6 0.43 6.38 0.33 6.17e-10 Facial morphology (factor 21, depth of nasal alae); CRC trans rs1712517 0.873 rs7916056 chr10:104997914 T/C cg23009290 chr3:125982568 NA 0.35 6.33 0.33 8.23e-10 Migraine; CRC cis rs9894429 1.000 rs11652797 chr17:79574124 A/G cg21028142 chr17:79581711 NPLOC4 0.38 8.34 0.42 2.06e-15 Eye color traits; CRC trans rs6956675 0.534 rs1806453 chr7:62641533 A/G cg01314568 chr7:57830625 NA 0.43 6.41 0.33 5.19e-10 Obesity-related traits; CRC cis rs6502050 0.777 rs11077969 chr17:80085633 A/G cg11859384 chr17:80120422 CCDC57 0.37 5.82 0.31 1.36e-8 Life satisfaction; CRC cis rs7605827 0.930 rs3805106 chr2:15535863 C/G cg19274914 chr2:15703543 NA 0.4 6.03 0.32 4.39e-9 Educational attainment (years of education); CRC cis rs10791323 0.660 rs2156681 chr11:133731644 G/T cg15485101 chr11:133734466 NA 0.47 8.65 0.43 2.32e-16 Childhood ear infection; CRC trans rs916888 0.610 rs199536 chr17:44820425 T/C cg10053473 chr17:62856997 LRRC37A3 0.63 8.89 0.44 3.98e-17 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs8103278 1.000 rs1548029 chr19:46309203 A/C cg11657440 chr19:46296263 DMWD -0.49 -6.87 -0.35 3.14e-11 Coronary artery disease; CRC cis rs4253772 0.513 rs6008612 chr22:46707907 G/A cg09491104 chr22:46646882 C22orf40 -0.42 -6.55 -0.34 2.27e-10 LDL cholesterol;Cholesterol, total; CRC cis rs4253772 0.678 rs9627281 chr22:46644168 A/G cg09491104 chr22:46646882 C22orf40 -0.43 -7.13 -0.37 6.59e-12 LDL cholesterol;Cholesterol, total; CRC cis rs34311866 0.808 rs4583705 chr4:973036 C/T cg07828340 chr4:882639 GAK 1.09 10.3 0.49 9.83e-22 Parkinson's disease; CRC trans rs3942852 0.806 rs10838805 chr11:48118993 A/C cg15704280 chr7:45808275 SEPT13 -0.63 -8.01 -0.4 1.95e-14 Acute lymphoblastic leukemia (childhood); CRC cis rs10504229 0.683 rs35840293 chr8:58117634 C/T cg05313129 chr8:58192883 C8orf71 -0.43 -6.11 -0.32 2.74e-9 Developmental language disorder (linguistic errors); CRC cis rs6141769 0.542 rs28456308 chr20:31273747 C/T cg13636640 chr20:31349939 DNMT3B -0.38 -5.74 -0.3 2.13e-8 Subjective well-being; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg13555728 chr17:77071390 ENGASE 0.5 7.19 0.37 4.33e-12 Anxiety disorder; CRC cis rs11252926 0.661 rs7077209 chr10:484159 A/G cg16386425 chr10:429943 DIP2C 0.39 5.75 0.3 2.08e-8 Psychosis in Alzheimer's disease; CRC cis rs4803455 0.565 rs11083616 chr19:41865643 A/G cg09537434 chr19:41945824 ATP5SL 0.57 8.53 0.43 5.6e-16 Migraine;Coronary artery disease; CRC cis rs12142240 0.698 rs112068407 chr1:46822291 T/C cg00530320 chr1:46809349 NSUN4 0.59 8.03 0.41 1.69e-14 Menopause (age at onset); CRC trans rs7310309 0.943 rs2307220 chr12:79985874 A/C cg25189608 chr11:96117844 CCDC82 -0.43 -6.0 -0.31 5.23e-9 Classic bladder exstrophy; CRC trans rs8073060 0.586 rs7213804 chr17:34010931 T/G cg19694781 chr19:47549865 TMEM160 -1.06 -14.24 -0.62 3.54e-36 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; CRC cis rs73200209 0.869 rs55862915 chr12:116695932 G/A cg01776926 chr12:116560359 MED13L -0.47 -5.8 -0.3 1.52e-8 Total body bone mineral density; CRC cis rs11792861 0.890 rs2900481 chr9:111831825 G/A cg05043794 chr9:111880884 C9orf5 -0.37 -6.7 -0.35 9.15e-11 Menarche (age at onset); CRC cis rs11191205 0.686 rs10786643 chr10:103394041 A/G cg15320455 chr10:103880129 LDB1 0.52 5.76 0.3 1.92e-8 Intelligence (multi-trait analysis); CRC cis rs35264875 1.000 rs1542334 chr11:68850773 G/C cg01993067 chr11:68851601 TPCN2 0.56 6.33 0.33 7.99e-10 Blond vs. brown hair color; CRC trans rs10269006 0.613 rs6953258 chr7:94375808 C/T cg05903386 chr2:217555456 IGFBP5 -0.37 -6.12 -0.32 2.67e-9 Breast cancer; CRC cis rs7429990 0.896 rs34448818 chr3:47841312 G/A cg11946769 chr3:48343235 NME6 0.56 6.43 0.33 4.52e-10 Educational attainment (years of education); CRC cis rs4974559 0.594 rs59544360 chr4:1313575 G/T cg02980000 chr4:1222292 CTBP1 0.46 5.79 0.3 1.65e-8 Systolic blood pressure; CRC cis rs6570726 0.791 rs383841 chr6:145888329 G/T cg13319975 chr6:146136371 FBXO30 0.46 6.94 0.36 2.03e-11 Lobe attachment (rater-scored or self-reported); CRC cis rs17270561 0.609 rs1937131 chr6:25744831 A/T cg16482183 chr6:26056742 HIST1H1C -0.85 -10.64 -0.51 6.44e-23 Iron status biomarkers; CRC cis rs9807989 0.839 rs4988956 chr2:102968007 G/A cg03938978 chr2:103052716 IL18RAP 0.37 5.97 0.31 6.2e-9 Asthma; CRC cis rs736408 0.562 rs13071584 chr3:52804487 T/C cg11645453 chr3:52864694 ITIH4 0.35 6.27 0.33 1.16e-9 Bipolar disorder; CRC cis rs1949733 0.816 rs2631746 chr4:8490934 C/T cg13073564 chr4:8508604 NA 0.44 7.13 0.37 6.56e-12 Response to antineoplastic agents; CRC trans rs6920965 0.583 rs9388456 chr6:126147197 C/T cg05039488 chr6:79577232 IRAK1BP1 -0.44 -6.6 -0.34 1.62e-10 High light scatter reticulocyte count; CRC cis rs10504229 1.000 rs17216620 chr8:58169412 A/G cg02725872 chr8:58115012 NA -0.39 -6.63 -0.34 1.38e-10 Developmental language disorder (linguistic errors); CRC cis rs6674176 0.542 rs803675 chr1:44353237 G/A cg12908607 chr1:44402522 ARTN -0.42 -6.94 -0.36 2.04e-11 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Cognitive ability; CRC cis rs861020 0.630 rs627069 chr1:210004613 C/G cg09163369 chr1:210001066 C1orf107 0.41 5.77 0.3 1.85e-8 Orofacial clefts; CRC cis rs561341 0.883 rs886224 chr17:30229902 T/C cg19193384 chr17:30244184 NA -0.58 -7.01 -0.36 1.33e-11 Hip circumference adjusted for BMI; CRC trans rs1728785 1.000 rs1645938 chr16:68595197 G/A cg04657470 chr2:198365150 HSPE1;HSPD1 0.59 7.14 0.37 5.95e-12 Ulcerative colitis; CRC cis rs11190604 0.697 rs10748795 chr10:102194818 A/T cg07080220 chr10:102295463 HIF1AN -0.48 -6.22 -0.32 1.52e-9 Palmitoleic acid (16:1n-7) levels; CRC cis rs7394190 0.748 rs60632610 chr10:75415677 C/T cg07699608 chr10:75541558 CHCHD1 0.59 6.08 0.32 3.34e-9 Incident atrial fibrillation; CRC cis rs6502050 0.835 rs4641801 chr17:80154021 G/A cg13198984 chr17:80129470 CCDC57 0.42 7.29 0.37 2.32e-12 Life satisfaction; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg20905746 chr15:79165638 MORF4L1 0.48 6.93 0.36 2.18e-11 Response to antipsychotic treatment; CRC cis rs4713118 0.513 rs156739 chr6:28013410 C/A cg12172441 chr6:28176163 NA 0.5 6.87 0.35 3.2e-11 Parkinson's disease; CRC cis rs2976388 0.647 rs2585136 chr8:143812141 A/G cg24046110 chr8:143859143 LYNX1 0.48 8.28 0.42 3.03e-15 Urinary tract infection frequency; CRC cis rs62103177 0.525 rs4799117 chr18:77756604 G/A cg02751453 chr18:77725136 HSBP1L1 0.46 5.69 0.3 2.8e-8 Opioid sensitivity; CRC cis rs7618915 0.547 rs4687636 chr3:52633929 G/A cg11645453 chr3:52864694 ITIH4 0.36 6.33 0.33 8.26e-10 Bipolar disorder; CRC cis rs9814567 1.000 rs9968172 chr3:134231251 A/G cg06541857 chr3:134203789 ANAPC13;CEP63 0.4 5.87 0.31 1.04e-8 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs6424115 0.830 rs6663474 chr1:24199642 G/A cg15997130 chr1:24165203 NA 0.72 10.62 0.51 7.31e-23 Immature fraction of reticulocytes; CRC cis rs62244186 0.627 rs12386385 chr3:44457540 A/G cg18165381 chr3:44552316 NA -0.39 -5.75 -0.3 2.01e-8 Depressive symptoms; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg01911186 chr12:12765398 CREBL2 0.51 7.38 0.38 1.28e-12 Response to antipsychotic treatment; CRC cis rs4665809 0.838 rs7565843 chr2:26292912 G/C cg22920501 chr2:26401640 FAM59B -0.53 -7.2 -0.37 4.05e-12 Gut microbiome composition (summer); CRC cis rs11809207 0.523 rs12565756 chr1:26498196 G/T cg24519413 chr1:26490540 NA 0.45 7.35 0.38 1.57e-12 Height; CRC cis rs172166 0.516 rs1225710 chr6:28100640 C/T cg12172441 chr6:28176163 NA -0.44 -6.38 -0.33 6.13e-10 Cardiac Troponin-T levels; CRC cis rs4713118 0.513 rs149954 chr6:28035246 G/A cg15786705 chr6:28176104 NA 0.6 8.62 0.43 2.91e-16 Parkinson's disease; CRC cis rs9788333 0.962 rs12584792 chr13:21887208 C/T cg23743428 chr13:21893420 NA -0.47 -9.09 -0.45 9.81e-18 Thiazide-induced adverse metabolic effects in hypertensive patients; CRC cis rs853679 0.517 rs9368556 chr6:28131153 T/C cg12273811 chr6:28175739 NA 0.73 9.16 0.45 5.8e-18 Depression; CRC cis rs4285028 0.948 rs12488334 chr3:121702526 T/C cg11130432 chr3:121712080 ILDR1 -0.52 -6.81 -0.35 4.73e-11 Multiple sclerosis; CRC cis rs9462846 1.000 rs9471950 chr6:42869040 G/A cg02353165 chr6:42928485 GNMT 0.54 6.96 0.36 1.9e-11 Blood protein levels; CRC trans rs1005277 0.563 rs2505215 chr10:38481273 A/G cg27523141 chr10:43048294 ZNF37B 0.47 6.74 0.35 7.02e-11 Extrinsic epigenetic age acceleration; CRC cis rs896854 0.624 rs9297949 chr8:95969445 A/C cg16049864 chr8:95962084 TP53INP1 -0.63 -11.61 -0.54 2.41e-26 Type 2 diabetes; CRC cis rs6860806 0.695 rs11952099 chr5:131576772 A/G cg11843238 chr5:131593191 PDLIM4 0.43 8.17 0.41 6.75e-15 Breast cancer; CRC cis rs7412746 0.658 rs59988025 chr1:150940358 C/T cg18016565 chr1:150552671 MCL1 0.44 6.17 0.32 2.03e-9 Melanoma; CRC cis rs10504229 0.639 rs56066782 chr8:58105857 A/G cg04204079 chr8:58130323 NA -0.46 -5.79 -0.3 1.67e-8 Developmental language disorder (linguistic errors); CRC cis rs8103278 0.507 rs8112282 chr19:46265029 C/T cg20908204 chr19:46285434 DMPK 0.33 7.45 0.38 8.47e-13 Coronary artery disease; CRC cis rs2573652 0.657 rs2573668 chr15:100541776 C/T cg00587665 chr15:100533223 ADAMTS17 0.33 5.73 0.3 2.21e-8 Height; CRC cis rs897984 0.568 rs56083427 chr16:30881298 C/T cg02466173 chr16:30829666 NA -0.67 -8.52 -0.43 5.75e-16 Dementia with Lewy bodies; CRC cis rs394563 0.591 rs6570963 chr6:149691355 T/G cg16235748 chr6:149772707 ZC3H12D 0.37 6.65 0.34 1.25e-10 Dupuytren's disease; CRC cis rs11105298 0.891 rs10777185 chr12:89921275 C/T cg08166232 chr12:89918718 WDR51B;GALNT4 -0.62 -7.89 -0.4 4.41e-14 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; CRC cis rs6951245 1.000 rs79683221 chr7:1096139 A/G cg18402987 chr7:1209562 NA 0.67 7.15 0.37 5.54e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs3764400 0.507 rs16954324 chr17:46324584 C/T cg10706073 chr17:46328419 SKAP1 -0.65 -6.83 -0.35 4.09e-11 Body mass index; CRC cis rs3806843 1.000 rs6579987 chr5:140183659 T/C cg19875535 chr5:140030758 IK 0.63 10.19 0.49 2.26e-21 Depressive symptoms (multi-trait analysis); CRC cis rs736408 0.812 rs9324 chr3:52825585 T/C cg10802521 chr3:52805072 NEK4 -0.45 -6.51 -0.34 2.8e-10 Bipolar disorder; CRC trans rs561341 1.000 rs1557731 chr17:30321567 T/G cg20587970 chr11:113659929 NA -1.16 -16.87 -0.68 1.93e-46 Hip circumference adjusted for BMI; CRC trans rs853679 0.607 rs33932084 chr6:28268824 A/G cg06606381 chr12:133084897 FBRSL1 -1.45 -11.27 -0.53 4.09e-25 Depression; CRC cis rs2933343 0.729 rs6767104 chr3:128648117 G/T cg25356066 chr3:128598488 ACAD9 -0.4 -5.75 -0.3 1.99e-8 IgG glycosylation; CRC cis rs6570726 0.846 rs9376954 chr6:145943737 T/A cg13319975 chr6:146136371 FBXO30 -0.43 -6.42 -0.33 4.84e-10 Lobe attachment (rater-scored or self-reported); CRC cis rs4927850 0.501 rs9881504 chr3:195656614 A/G cg22809023 chr3:195622598 TNK2 0.43 5.61 0.3 4.38e-8 Pancreatic cancer; CRC cis rs28386778 0.769 rs6504179 chr17:61812995 T/G cg22520471 chr17:61851767 DDX42;CCDC47 0.68 10.12 0.49 3.89e-21 Prudent dietary pattern; CRC cis rs11148252 0.574 rs61958118 chr13:53170226 C/T cg12458913 chr13:53173898 NA 0.79 14.63 0.63 1.12e-37 Lewy body disease; CRC trans rs2303319 0.504 rs1449641 chr2:162619567 T/C cg22677401 chr17:46026860 NA -0.67 -6.09 -0.32 3.14e-9 Cognitive function; CRC trans rs7267979 0.966 rs910996 chr20:25264196 A/G cg17903999 chr18:56338584 MALT1 -0.41 -6.77 -0.35 5.78e-11 Liver enzyme levels (alkaline phosphatase); CRC cis rs4938330 0.680 rs4938329 chr11:116928112 C/T cg01368799 chr11:117014884 PAFAH1B2 -0.4 -5.76 -0.3 1.93e-8 Blood protein levels; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg18450072 chr4:40058936 LOC344967;N4BP2 0.43 6.59 0.34 1.76e-10 Liver disease severity in Alagille syndrome; CRC cis rs10256972 0.641 rs12702017 chr7:1129413 C/T cg23978390 chr7:1156363 C7orf50 0.53 7.34 0.38 1.63e-12 Longevity;Endometriosis; CRC trans rs7395662 0.591 rs11039776 chr11:48516706 G/A cg15704280 chr7:45808275 SEPT13 -0.47 -6.69 -0.35 9.51e-11 HDL cholesterol; CRC cis rs7659604 0.539 rs3217753 chr4:122746325 A/G cg06713675 chr4:122721982 EXOSC9 -0.51 -8.33 -0.42 2.27e-15 Type 2 diabetes; CRC cis rs13256369 1.000 rs7843488 chr8:8576217 C/T cg17143192 chr8:8559678 CLDN23 0.5 6.36 0.33 6.72e-10 Obesity-related traits; CRC cis rs17767392 0.813 rs35831373 chr14:71918421 C/T cg13720639 chr14:72061746 SIPA1L1 -0.5 -6.37 -0.33 6.37e-10 Mitral valve prolapse; CRC cis rs10540 0.915 rs12419209 chr11:494510 T/C cg03352830 chr11:487213 PTDSS2 0.67 7.7 0.39 1.63e-13 Body mass index; CRC cis rs362296 0.511 rs2857861 chr4:3323767 C/T cg16416165 chr4:3325029 RGS12 0.42 7.15 0.37 5.62e-12 Parental longevity (mother's age at death); CRC cis rs17152411 0.895 rs61872121 chr10:126586795 T/C cg07906193 chr10:126599966 NA 0.56 6.33 0.33 7.97e-10 Height; CRC trans rs61931739 0.500 rs35391785 chr12:34444478 C/T cg26384229 chr12:38710491 ALG10B 0.67 8.88 0.44 4.26e-17 Morning vs. evening chronotype; CRC cis rs3733585 0.673 rs4292333 chr4:9953871 G/A cg11266682 chr4:10021025 SLC2A9 -0.47 -9.62 -0.47 1.76e-19 Cleft plate (environmental tobacco smoke interaction); CRC cis rs7605827 0.866 rs11678132 chr2:15533998 C/T cg19274914 chr2:15703543 NA 0.39 5.88 0.31 9.87e-9 Educational attainment (years of education); CRC cis rs9486715 0.838 rs4839840 chr6:96941149 T/C cg18709589 chr6:96969512 KIAA0776 0.48 7.11 0.36 7.25e-12 Headache; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg15121053 chr7:138818439 TTC26 0.41 6.73 0.35 7.55e-11 Liver disease severity in Alagille syndrome; CRC trans rs1005277 0.579 rs2021649 chr10:38392122 C/T cg17830980 chr10:43048298 ZNF37B -0.6 -9.98 -0.48 1.13e-20 Extrinsic epigenetic age acceleration; CRC cis rs8177179 0.967 rs4443173 chr3:133439378 A/G cg24879335 chr3:133465180 TF 0.44 8.6 0.43 3.2e-16 Iron status biomarkers (transferrin levels); CRC cis rs780096 0.526 rs10182937 chr2:27651693 T/C cg12648201 chr2:27665141 KRTCAP3 -0.31 -6.18 -0.32 1.88e-9 Total body bone mineral density; CRC cis rs4713118 0.621 rs9368548 chr6:28034737 A/G cg23161317 chr6:28129485 ZNF389 0.51 6.45 0.34 3.93e-10 Parkinson's disease; CRC cis rs68170813 0.599 rs12533516 chr7:106937135 C/T cg02696742 chr7:106810147 HBP1 -0.6 -6.64 -0.34 1.3e-10 Coronary artery disease; CRC cis rs11971779 0.680 rs6962186 chr7:139034806 T/C cg23387468 chr7:139079360 LUC7L2 0.41 7.05 0.36 1.03e-11 Diisocyanate-induced asthma; CRC cis rs12701220 0.689 rs12536282 chr7:1115650 C/T cg00990874 chr7:1149470 C7orf50 -0.51 -6.01 -0.31 5.01e-9 Bronchopulmonary dysplasia; CRC cis rs11122272 0.735 rs2491412 chr1:231535880 A/T cg06096015 chr1:231504339 EGLN1 0.4 6.04 0.32 4.19e-9 Hemoglobin concentration; CRC cis rs1448094 0.842 rs7978562 chr12:86451478 A/G cg18827107 chr12:86230957 RASSF9 -0.36 -5.74 -0.3 2.15e-8 Major depressive disorder; CRC cis rs60871478 0.579 rs56109762 chr7:925967 G/A cg13798912 chr7:905769 UNC84A -0.7 -7.02 -0.36 1.3e-11 Cerebrospinal P-tau181p levels; CRC cis rs7666738 0.791 rs13127542 chr4:98949159 C/T cg17366294 chr4:99064904 C4orf37 0.43 7.34 0.38 1.69e-12 Colonoscopy-negative controls vs population controls; CRC cis rs8141529 0.509 rs5762864 chr22:29253364 T/C cg15103426 chr22:29168792 CCDC117 0.55 7.58 0.39 3.44e-13 Lymphocyte counts; CRC cis rs875971 0.862 rs778697 chr7:65870426 G/A cg18876405 chr7:65276391 NA 0.54 8.69 0.43 1.77e-16 Aortic root size; CRC cis rs7412746 0.658 rs6677420 chr1:150946490 G/A cg10589385 chr1:150898437 SETDB1 0.33 6.95 0.36 1.94e-11 Melanoma; CRC cis rs4434138 0.683 rs13063160 chr3:52602274 T/C cg15147215 chr3:52552868 STAB1 -0.63 -11.02 -0.52 2.91e-24 Intelligence (multi-trait analysis); CRC cis rs10905065 0.829 rs2246399 chr10:5799286 T/A cg11519256 chr10:5708881 ASB13 -0.51 -7.57 -0.39 3.82e-13 Menopause (age at onset); CRC cis rs875971 0.545 rs221986 chr7:65570310 T/C cg11764359 chr7:65958608 NA -0.45 -5.71 -0.3 2.47e-8 Aortic root size; CRC cis rs6460942 0.915 rs72584550 chr7:12304990 G/A cg06484146 chr7:12443880 VWDE -0.54 -6.98 -0.36 1.68e-11 Coronary artery disease; CRC cis rs8060686 0.858 rs8051587 chr16:67796315 A/C cg26727032 chr16:67993705 SLC12A4 -0.72 -11.37 -0.53 1.75e-25 HDL cholesterol;Metabolic syndrome; CRC cis rs951366 0.789 rs823110 chr1:205701078 G/C cg14159672 chr1:205819179 PM20D1 0.72 10.6 0.5 9.11e-23 Menarche (age at onset); CRC cis rs4689388 0.856 rs10016157 chr4:6294414 T/C cg14416269 chr4:6271139 WFS1 0.4 6.59 0.34 1.72e-10 Type 2 diabetes and other traits;Type 2 diabetes; CRC cis rs4909189 1.000 rs71547530 chr7:158135503 A/G cg24154853 chr7:158122151 PTPRN2 0.51 7.03 0.36 1.2e-11 Response to amphetamines; CRC cis rs2050392 1.000 rs2480280 chr10:30696092 A/G cg18806716 chr10:30721971 MAP3K8 -0.47 -7.07 -0.36 9.51e-12 Inflammatory bowel disease; CRC cis rs13108904 0.870 rs13110563 chr4:1255772 G/C cg21620606 chr4:1342894 KIAA1530 0.39 6.81 0.35 4.56e-11 Obesity-related traits; CRC cis rs908922 0.676 rs539393 chr1:152518896 C/T cg09873164 chr1:152488093 CRCT1 0.37 6.29 0.33 1e-9 Hair morphology; CRC cis rs6426558 0.537 rs498020 chr1:227304180 G/A cg10327440 chr1:227177885 CDC42BPA 0.45 6.79 0.35 5.1e-11 Neutrophil percentage of white cells; CRC cis rs629535 0.814 rs558511 chr8:70069908 C/A cg26132723 chr8:70041827 NA 0.35 5.77 0.3 1.8e-8 Dupuytren's disease; CRC trans rs3733585 0.699 rs4339211 chr4:9947658 C/T cg26043149 chr18:55253948 FECH -0.44 -6.65 -0.34 1.22e-10 Cleft plate (environmental tobacco smoke interaction); CRC cis rs1044826 0.619 rs6439856 chr3:139134868 A/T cg00490450 chr3:139108681 COPB2 -0.48 -7.19 -0.37 4.3e-12 Obesity-related traits; CRC cis rs4713118 0.955 rs9468203 chr6:27688667 A/G cg19041857 chr6:27730383 NA -0.46 -6.36 -0.33 6.68e-10 Parkinson's disease; CRC trans rs6940638 0.956 rs12203454 chr6:27031100 C/T cg06606381 chr12:133084897 FBRSL1 -0.6 -6.52 -0.34 2.71e-10 Intelligence (multi-trait analysis); CRC cis rs2227564 0.620 rs4746148 chr10:75534488 C/T cg16540259 chr10:75572220 NDST2 0.51 7.86 0.4 5.61e-14 Crohn's disease;Inflammatory bowel disease; CRC cis rs9916302 0.660 rs4795367 chr17:37608843 G/C cg07936489 chr17:37558343 FBXL20 -0.93 -11.91 -0.55 1.88e-27 Glomerular filtration rate (creatinine); CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg20263490 chr11:3013628 NAP1L4 0.46 6.43 0.33 4.57e-10 Anxiety disorder; CRC cis rs7208859 0.673 rs73263755 chr17:29198972 A/G cg01831904 chr17:28903510 LRRC37B2 -0.55 -5.77 -0.3 1.88e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs3824867 0.959 rs4237544 chr11:47454271 G/T cg05585544 chr11:47624801 NA 0.41 6.29 0.33 1.04e-9 Mean corpuscular hemoglobin; CRC cis rs1862618 0.853 rs252898 chr5:56188931 T/C cg20203395 chr5:56204925 C5orf35 -0.71 -8.15 -0.41 7.76e-15 Initial pursuit acceleration; CRC cis rs9611565 0.921 rs3927 chr22:41722864 A/G cg06634786 chr22:41940651 POLR3H -0.51 -6.26 -0.33 1.19e-9 Vitiligo; CRC cis rs9911578 0.935 rs7216698 chr17:57007495 G/A cg05425664 chr17:57184151 TRIM37 -0.43 -6.76 -0.35 6.14e-11 Intelligence (multi-trait analysis); CRC cis rs9467711 0.651 rs13197334 chr6:26122648 G/C cg08501292 chr6:25962987 TRIM38 0.64 6.14 0.32 2.41e-9 Autism spectrum disorder or schizophrenia; CRC cis rs1348850 0.567 rs3770005 chr2:178528874 A/G cg22681709 chr2:178499509 PDE11A -0.46 -8.47 -0.42 8.45e-16 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs6502050 0.799 rs4789680 chr17:80100547 C/A cg02741985 chr17:80059408 CCDC57 0.43 7.15 0.37 5.66e-12 Life satisfaction; CRC cis rs6502050 0.871 rs9916649 chr17:80075739 G/A cg13198984 chr17:80129470 CCDC57 -0.48 -8.57 -0.43 3.99e-16 Life satisfaction; CRC cis rs1881797 1.000 rs12081895 chr1:247686666 C/G cg05639522 chr1:247681581 NA 0.46 6.98 0.36 1.68e-11 Acute lymphoblastic leukemia (childhood); CRC cis rs6860806 0.661 rs6890009 chr5:131580033 G/T cg20512303 chr5:131592959 PDLIM4 0.3 5.63 0.3 3.84e-8 Breast cancer; CRC cis rs3771570 1.000 rs56383420 chr2:242219281 A/G cg21155796 chr2:242212141 HDLBP 0.64 6.99 0.36 1.54e-11 Prostate cancer; CRC trans rs459571 0.959 rs392134 chr9:136909008 G/A cg09836344 chr4:1243392 C4orf42;CTBP1 -0.81 -11.16 -0.52 9.34e-25 Platelet distribution width; CRC cis rs801193 0.967 rs3800823 chr7:66147110 C/A cg00343986 chr7:65444356 GUSB -0.45 -6.49 -0.34 3.08e-10 Aortic root size; CRC cis rs10751667 0.643 rs12278229 chr11:946985 A/G cg01483505 chr11:975446 AP2A2 0.41 6.53 0.34 2.48e-10 Alzheimer's disease (late onset); CRC cis rs6504622 0.557 rs10853085 chr17:44995070 G/A cg16759221 chr17:45003025 GOSR2 0.6 9.67 0.47 1.28e-19 Orofacial clefts; CRC trans rs4942242 0.663 rs1472330 chr13:44209628 A/G cg19169023 chr15:41853346 TYRO3 0.58 8.03 0.4 1.72e-14 Response to tocilizumab in rheumatoid arthritis; CRC cis rs2976388 0.566 rs13250661 chr8:143804134 C/T cg24634471 chr8:143751801 JRK -0.44 -6.26 -0.33 1.2e-9 Urinary tract infection frequency; CRC trans rs6703335 0.870 rs10803142 chr1:243598234 A/G cg15609273 chr13:50159867 RCBTB1 0.48 6.75 0.35 6.87e-11 Schizophrenia;Schizophrenia, schizoaffective disorder or bipolar disorder; CRC cis rs6964587 1.000 rs17164263 chr7:91581566 T/A cg17063962 chr7:91808500 NA -0.79 -13.8 -0.61 1.73e-34 Breast cancer; CRC cis rs8014204 0.935 rs2853779 chr14:75368508 G/A cg03030879 chr14:75389066 RPS6KL1 0.55 9.12 0.45 7.84e-18 Caffeine consumption; CRC cis rs6834538 0.520 rs17668083 chr4:113422875 C/T cg10021238 chr4:113569128 MIR367;LARP7 -0.37 -5.8 -0.3 1.55e-8 Free thyroxine concentration; CRC cis rs7617480 0.587 rs9311431 chr3:48848787 T/A cg07636037 chr3:49044803 WDR6 0.87 10.5 0.5 2e-22 Subjective well-being (multi-trait analysis);Menarche (age at onset); CRC trans rs1728785 1.000 rs7118 chr16:68600855 G/T cg04657470 chr2:198365150 HSPE1;HSPD1 0.59 7.14 0.37 6.11e-12 Ulcerative colitis; CRC cis rs6921919 0.609 rs36018474 chr6:28385529 C/G cg21251018 chr6:28226885 NKAPL 0.4 6.01 0.31 4.96e-9 Autism spectrum disorder or schizophrenia; CRC cis rs6088580 0.634 rs6142164 chr20:33006597 C/T cg08999081 chr20:33150536 PIGU -0.62 -11.52 -0.54 5.05e-26 Glomerular filtration rate (creatinine); CRC cis rs7618915 0.501 rs13085775 chr3:52678370 C/T cg11645453 chr3:52864694 ITIH4 0.37 6.59 0.34 1.78e-10 Bipolar disorder; CRC cis rs208520 0.526 rs9354370 chr6:66808209 C/T cg07460842 chr6:66804631 NA 1.15 24.03 0.8 2.08e-74 Exhaled nitric oxide output; CRC cis rs600806 0.850 rs4970846 chr1:109946095 A/C cg23032129 chr1:109941072 SORT1 -0.27 -5.74 -0.3 2.16e-8 Intelligence (multi-trait analysis); CRC trans rs2243480 1.000 rs4548056 chr7:65298873 A/G cg10756647 chr7:56101905 PSPH 0.73 7.79 0.39 8.9e-14 Diabetic kidney disease; CRC cis rs6570726 0.934 rs9484995 chr6:145781114 T/A cg05347473 chr6:146136440 FBXO30 -0.37 -5.65 -0.3 3.57e-8 Lobe attachment (rater-scored or self-reported); CRC trans rs7618501 0.521 rs2352984 chr3:49948728 T/C cg21659725 chr3:3221576 CRBN 0.47 6.86 0.35 3.47e-11 Intelligence (multi-trait analysis); CRC cis rs9287719 0.601 rs13427815 chr2:10707985 C/T cg00105475 chr2:10696890 NA 0.47 7.28 0.37 2.46e-12 Prostate cancer; CRC cis rs7246657 0.943 rs2112923 chr19:37940327 C/T cg23950597 chr19:37808831 NA -0.49 -6.05 -0.32 3.93e-9 Coronary artery calcification; CRC cis rs11098499 0.818 rs55825515 chr4:120486402 A/G cg09307838 chr4:120376055 NA 0.67 9.96 0.48 1.38e-20 Corneal astigmatism; CRC cis rs1799949 0.965 rs4239149 chr17:41328095 A/G cg25072359 chr17:41440525 NA -0.53 -8.55 -0.43 4.64e-16 Menopause (age at onset); CRC trans rs7613875 0.600 rs2624826 chr3:50155468 T/G cg21659725 chr3:3221576 CRBN -0.44 -6.35 -0.33 7.19e-10 Body mass index; CRC cis rs12762955 0.561 rs7076107 chr10:1043647 T/C cg20503657 chr10:835505 NA -0.48 -6.67 -0.35 1.1e-10 Response to angiotensin II receptor blocker therapy; CRC trans rs7395662 1.000 rs11039862 chr11:48618306 A/G cg21153622 chr11:89784906 NA -0.45 -7.11 -0.36 7.35e-12 HDL cholesterol; CRC cis rs1799949 0.965 rs11658499 chr17:41334749 C/T cg19454999 chr17:41278357 BRCA1;NBR2 0.54 8.36 0.42 1.84e-15 Menopause (age at onset); CRC trans rs1814175 0.817 rs10769613 chr11:49769692 G/A cg11707556 chr5:10655725 ANKRD33B -0.42 -7.82 -0.4 7.43e-14 Height; CRC cis rs17092148 1.000 rs910871 chr20:33333208 C/A cg08999081 chr20:33150536 PIGU 0.46 5.73 0.3 2.24e-8 Neuroticism; CRC cis rs883565 0.655 rs7629839 chr3:39115294 G/A cg01426195 chr3:39028469 NA -0.55 -8.89 -0.44 3.98e-17 Handedness; CRC cis rs9291683 0.530 rs6449196 chr4:9973660 C/T cg11266682 chr4:10021025 SLC2A9 -0.51 -10.53 -0.5 1.53e-22 Bone mineral density; CRC cis rs1113500 0.933 rs4593854 chr1:108638519 A/G cg06207961 chr1:108661230 NA 0.4 5.76 0.3 1.94e-8 Growth-regulated protein alpha levels; CRC cis rs10504229 1.000 rs17805549 chr8:58179653 T/C cg22535103 chr8:58192502 C8orf71 -0.82 -12.27 -0.56 9.63e-29 Developmental language disorder (linguistic errors); CRC cis rs2228479 0.850 rs45524643 chr16:89815824 G/A cg19635926 chr16:89946313 TCF25 0.66 5.97 0.31 6.1e-9 Skin colour saturation; CRC cis rs10504229 0.638 rs7826839 chr8:58132075 G/T cg24829409 chr8:58192753 C8orf71 -0.55 -8.03 -0.4 1.71e-14 Developmental language disorder (linguistic errors); CRC cis rs2734839 0.537 rs1554929 chr11:113278764 C/T cg14159747 chr11:113255604 NA 0.58 11.78 0.54 5.93e-27 Information processing speed; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg06742493 chr19:13056745 RAD23A 0.45 7.37 0.38 1.41e-12 Liver disease severity in Alagille syndrome; CRC cis rs67311347 0.955 rs12487955 chr3:40412853 T/C cg09455208 chr3:40491958 NA 0.43 8.69 0.43 1.79e-16 Renal cell carcinoma; CRC cis rs344364 0.529 rs186941 chr16:1930088 T/C cg03013636 chr16:1946785 NA -0.49 -6.0 -0.31 5.1e-9 Glomerular filtration rate in chronic kidney disease; CRC cis rs798554 0.679 rs13230995 chr7:2887284 G/A cg13628971 chr7:2884303 GNA12 0.62 8.94 0.44 2.94e-17 Height; CRC cis rs1799949 0.965 rs11080034 chr17:41443014 T/C cg25072359 chr17:41440525 NA 0.54 8.63 0.43 2.58e-16 Menopause (age at onset); CRC cis rs6066835 0.764 rs2426097 chr20:47385467 C/T cg18078177 chr20:47281410 PREX1 0.67 5.97 0.31 6.05e-9 Multiple myeloma; CRC cis rs6540559 0.673 rs6694552 chr1:209976459 A/C cg25204440 chr1:209979598 IRF6 0.48 5.76 0.3 1.89e-8 Cleft lip with or without cleft palate; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg13687825 chr8:101225344 SPAG1 0.44 6.19 0.32 1.81e-9 Anxiety disorder; CRC cis rs7615952 0.512 rs1077621 chr3:125819799 A/G cg05084668 chr3:125655381 ALG1L -0.45 -6.32 -0.33 8.38e-10 Blood pressure (smoking interaction); CRC cis rs1153858 1.000 rs10519021 chr15:45631795 G/A cg10760299 chr15:45669010 GATM 0.49 7.72 0.39 1.41e-13 Homoarginine levels; CRC cis rs3741404 0.825 rs60452247 chr11:63981507 G/A cg18225595 chr11:63971243 STIP1 0.66 10.95 0.52 5.24e-24 Platelet count; CRC cis rs6748734 0.857 rs4675857 chr2:241842326 T/C cg04034577 chr2:241836375 C2orf54 -0.42 -8.62 -0.43 2.87e-16 Urinary metabolites; CRC cis rs2075371 1.000 rs2544210 chr7:133971535 C/T cg20476274 chr7:133979776 SLC35B4 0.79 14.2 0.62 5.14e-36 Mean platelet volume; CRC cis rs873946 0.590 rs7071777 chr10:134559976 T/A cg06453172 chr10:134556979 INPP5A -0.63 -7.55 -0.38 4.39e-13 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CRC cis rs11583043 0.918 rs6693456 chr1:101424561 A/G cg00063077 chr1:101360652 SLC30A7;EXTL2 0.45 6.03 0.32 4.43e-9 Ulcerative colitis;Inflammatory bowel disease; CRC cis rs34779708 0.966 rs4934538 chr10:35472150 T/C cg03585969 chr10:35415529 CREM 0.64 8.55 0.43 4.78e-16 Inflammatory bowel disease;Crohn's disease; CRC cis rs6743226 0.934 rs7565186 chr2:242249822 A/G cg10021735 chr2:242295487 FARP2 0.47 6.9 0.36 2.73e-11 Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI in non-smokers; CRC cis rs8180040 0.654 rs13078131 chr3:47204939 G/T cg27129171 chr3:47204927 SETD2 0.77 13.31 0.59 1.26e-32 Colorectal cancer; CRC cis rs6582630 0.615 rs12821226 chr12:38546406 C/T cg26384229 chr12:38710491 ALG10B -0.52 -7.56 -0.38 4.18e-13 Drug-induced liver injury (flucloxacillin); CRC cis rs6066835 0.867 rs11907586 chr20:47374058 G/A cg18078177 chr20:47281410 PREX1 0.69 5.89 0.31 9.56e-9 Multiple myeloma; CRC cis rs67478160 0.583 rs12879612 chr14:104233618 T/A cg01849466 chr14:104193079 ZFYVE21 -0.49 -8.58 -0.43 3.73e-16 Schizophrenia; CRC cis rs6933660 0.512 rs13202634 chr6:151800630 C/T cg10883421 chr6:151773342 RMND1;C6orf211 0.63 7.13 0.37 6.55e-12 Menarche (age at onset); CRC cis rs2227564 0.649 rs2948689 chr10:75657860 A/G cg00564723 chr10:75632066 CAMK2G -0.33 -7.52 -0.38 5.41e-13 Crohn's disease;Inflammatory bowel disease; CRC cis rs6598955 0.670 rs7520517 chr1:26556385 A/C cg04990556 chr1:26633338 UBXN11 -0.79 -13.38 -0.59 6.52e-33 Obesity-related traits; CRC trans rs17685 0.753 rs869806 chr7:75688623 C/T cg19862616 chr7:65841803 NCRNA00174 0.99 18.55 0.71 4.31e-53 Coffee consumption;Coffee consumption (cups per day); CRC cis rs6496667 0.865 rs7169251 chr15:90884262 T/C cg04176472 chr15:90893244 GABARAPL3 0.56 6.49 0.34 3.22e-10 Rheumatoid arthritis; CRC cis rs2180341 0.843 rs4895821 chr6:127572761 T/A cg24812749 chr6:127587940 RNF146 0.92 13.34 0.59 9.16e-33 Breast cancer; CRC cis rs911119 0.955 rs8115423 chr20:23605253 T/C cg16589663 chr20:23618590 CST3 0.45 6.35 0.33 7.25e-10 Chronic kidney disease; CRC cis rs887829 0.588 rs4663969 chr2:234655313 C/A cg02227331 chr2:234663937 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 0.41 6.6 0.34 1.6e-10 Metabolic traits;Bilirubin levels;Cholelithiasis-related traits in sickle cell anemia;Metabolite levels;Total bilirubin levels in HIV-1 infection;Serum metabolite levels;Blood metabolite levels; CRC cis rs9534288 0.699 rs9534320 chr13:46665572 A/G cg15192986 chr13:46630673 CPB2 -0.61 -8.47 -0.42 8.09e-16 Blood protein levels; CRC cis rs9894429 0.646 rs9905639 chr17:79614154 A/G cg21028142 chr17:79581711 NPLOC4 0.34 7.28 0.37 2.49e-12 Eye color traits; CRC cis rs1552244 1.000 rs17032396 chr3:10153559 A/G cg02579736 chr3:10068473 FANCD2;CIDECP -1.02 -13.52 -0.6 1.97e-33 Alzheimer's disease; CRC trans rs10982213 0.830 rs2274163 chr9:117188714 C/T cg16308101 chr1:67895914 SERBP1 0.49 7.75 0.39 1.13e-13 Interleukin-6 levels; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg20647962 chr15:41136443 SPINT1 0.36 5.97 0.31 6.06e-9 Liver disease severity in Alagille syndrome; CRC cis rs56104184 0.775 rs56149557 chr19:49401384 C/A cg21252483 chr19:49399788 TULP2 -0.43 -6.52 -0.34 2.59e-10 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; CRC cis rs6570726 0.935 rs424263 chr6:145840073 A/C cg23711669 chr6:146136114 FBXO30 0.68 12.16 0.56 2.33e-28 Lobe attachment (rater-scored or self-reported); CRC cis rs4821897 0.514 rs739141 chr22:39824450 A/G cg11247378 chr22:39784982 NA 0.39 7.31 0.37 2.1e-12 IgG glycosylation; CRC cis rs7677751 0.806 rs7681399 chr4:55090886 T/G cg13615338 chr4:55094005 PDGFRA 0.43 6.2 0.32 1.73e-9 Corneal astigmatism; CRC trans rs1455244 0.700 rs7229302 chr18:11508904 G/T cg18094551 chr22:20004364 ARVCF 0.4 6.31 0.33 9.05e-10 Schizophrenia; CRC cis rs9969804 0.846 rs912260 chr9:95493279 C/G cg14631576 chr9:95140430 CENPP -0.32 -5.95 -0.31 6.73e-9 Height; CRC cis rs12950390 0.893 rs4794110 chr17:45847230 A/G cg24803719 chr17:45855879 NA -0.3 -6.67 -0.35 1.08e-10 IgG glycosylation; CRC cis rs2455601 0.574 rs2568094 chr11:8992218 A/G cg21881798 chr11:8931708 C11orf17;ST5 -0.53 -6.26 -0.33 1.19e-9 Schizophrenia; CRC cis rs4629710 0.592 rs9492868 chr6:131542238 A/C cg12606694 chr6:131520996 AKAP7 0.55 8.17 0.41 6.77e-15 Multiple myeloma (IgH translocation); CRC cis rs71403859 0.730 rs12446333 chr16:71752157 T/C cg08717414 chr16:71523259 ZNF19 -0.99 -8.52 -0.43 5.81e-16 Post bronchodilator FEV1; CRC cis rs76419734 0.510 rs28391170 chr4:106629246 A/C cg24545054 chr4:106630052 GSTCD;INTS12 0.62 7.73 0.39 1.28e-13 Post bronchodilator FEV1; CRC cis rs4713118 0.868 rs2893928 chr6:27738430 C/A cg25164649 chr6:28176230 NA 0.72 7.98 0.4 2.4e-14 Parkinson's disease; CRC cis rs75422866 0.510 rs74733564 chr12:48118427 C/G cg14736327 chr12:48174669 SLC48A1 -0.72 -5.75 -0.3 2.05e-8 Pneumonia; CRC cis rs644799 0.710 rs3748253 chr11:95519506 G/A cg25478527 chr11:95522999 CEP57;FAM76B 0.49 7.62 0.39 2.78e-13 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs2120019 1.000 rs35577967 chr15:75354621 G/A cg11632617 chr15:75315747 PPCDC -0.54 -7.27 -0.37 2.65e-12 Blood trace element (Zn levels); CRC cis rs11122272 0.735 rs11122281 chr1:231519842 A/G cg06096015 chr1:231504339 EGLN1 0.4 5.94 0.31 7.17e-9 Hemoglobin concentration; CRC trans rs7615952 0.546 rs112919177 chr3:125346070 G/A cg21747405 chr11:67723411 NA -0.49 -6.32 -0.33 8.59e-10 Blood pressure (smoking interaction); CRC trans rs57221529 0.766 rs72703065 chr5:588123 C/A cg11887960 chr12:57824829 NA 0.63 6.89 0.36 2.93e-11 Lung disease severity in cystic fibrosis; CRC cis rs10743315 0.643 rs75398828 chr12:19340053 T/C cg02471346 chr12:19282374 PLEKHA5 0.67 6.18 0.32 1.91e-9 Gut microbiota (bacterial taxa); CRC cis rs501120 1.000 rs1746047 chr10:44774086 T/G cg09554077 chr10:44749378 NA 0.78 11.78 0.54 5.88e-27 Coronary artery disease;Coronary heart disease; CRC cis rs10769945 0.730 rs217208 chr11:1974892 C/G cg23202291 chr11:1979235 NA -0.46 -6.57 -0.34 1.93e-10 DNA methylation (variation); CRC cis rs7539542 0.556 rs2000331 chr1:202857578 G/T cg19681188 chr1:202830198 LOC148709 0.46 6.56 0.34 2.05e-10 Mean platelet volume; CRC cis rs4665809 0.618 rs7579199 chr2:26266496 G/A cg26119090 chr2:26468346 HADHA;HADHB -0.62 -7.99 -0.4 2.36e-14 Gut microbiome composition (summer); CRC cis rs6088590 0.965 rs6120730 chr20:33385102 G/C cg24642439 chr20:33292090 TP53INP2 0.6 10.6 0.5 8.53e-23 Coronary artery disease; CRC cis rs1218582 0.772 rs11264282 chr1:154867370 G/A cg16680214 chr1:154839983 KCNN3 -0.48 -9.51 -0.46 4.08e-19 Prostate cancer; CRC cis rs10870270 0.784 rs10430614 chr10:133748640 C/T cg17892150 chr10:133769511 PPP2R2D 0.66 10.13 0.49 3.61e-21 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; CRC cis rs10046574 0.519 rs112479683 chr7:135203288 G/A cg27474649 chr7:135195673 CNOT4 0.62 5.97 0.31 6.28e-9 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs5750830 0.649 rs5750808 chr22:39790987 G/A cg05872129 chr22:39784769 NA -0.59 -10.79 -0.51 1.87e-23 Intelligence (multi-trait analysis); CRC cis rs11229555 1.000 rs8373 chr11:58378424 A/G cg15696309 chr11:58395628 NA -0.95 -13.36 -0.59 7.99e-33 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; CRC trans rs7615952 0.800 rs2062773 chr3:125639648 T/C cg07211511 chr3:129823064 LOC729375 -1.12 -19.3 -0.73 5.07e-56 Blood pressure (smoking interaction); CRC cis rs7937682 0.562 rs12275761 chr11:111367083 T/A cg19812747 chr11:111475976 SIK2 0.46 7.22 0.37 3.58e-12 Primary sclerosing cholangitis; CRC cis rs61160187 0.582 rs976630 chr5:60215481 A/C cg16298547 chr5:60138761 ELOVL7 -0.28 -5.94 -0.31 7.36e-9 Educational attainment (years of education);Educational attainment (college completion); CRC cis rs7927771 0.507 rs7119517 chr11:47675316 T/C cg20307385 chr11:47447363 PSMC3 0.47 7.0 0.36 1.43e-11 Subjective well-being; CRC cis rs9399137 0.507 rs12663810 chr6:135289782 G/C cg22676075 chr6:135203613 NA 0.59 8.8 0.44 7.76e-17 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; CRC cis rs7666738 0.830 rs2865980 chr4:99027422 T/G cg17366294 chr4:99064904 C4orf37 0.44 7.45 0.38 8.22e-13 Colonoscopy-negative controls vs population controls; CRC trans rs9929218 0.906 rs9932679 chr16:68751904 A/G cg04657470 chr2:198365150 HSPE1;HSPD1 -0.97 -13.87 -0.61 9.25e-35 Colorectal cancer; CRC cis rs72615157 0.539 rs12673441 chr7:99670328 A/T cg22004693 chr7:99632812 ZKSCAN1 0.42 6.5 0.34 3.04e-10 Lung function (FEV1/FVC); CRC cis rs2404602 0.684 rs4886816 chr15:76874707 A/C cg23625390 chr15:77176239 SCAPER -0.91 -15.3 -0.64 2.77e-40 Blood metabolite levels; CRC cis rs7089973 0.844 rs10510007 chr10:116636721 A/G cg23260525 chr10:116636907 FAM160B1 0.31 6.72 0.35 8.05e-11 Bipolar disorder or attention deficit hyperactivity disorder; CRC cis rs599083 0.530 rs689179 chr11:68179166 A/G cg16797656 chr11:68205561 LRP5 -0.41 -6.55 -0.34 2.28e-10 Bone mineral density (spine); CRC cis rs3091242 0.933 rs10903130 chr1:25769221 A/T cg20684491 chr1:25596433 NA 0.43 7.45 0.38 8.23e-13 Erythrocyte sedimentation rate; CRC cis rs7264396 0.563 rs2425109 chr20:34316218 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.49 -6.78 -0.35 5.73e-11 Total cholesterol levels; CRC cis rs4665809 1.000 rs1371553 chr2:26262948 G/A cg22920501 chr2:26401640 FAM59B -0.52 -7.12 -0.37 6.67e-12 Gut microbiome composition (summer); CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg07003744 chr7:30325402 ZNRF2 0.46 6.04 0.32 4.1e-9 Anxiety disorder; CRC cis rs7428 0.847 rs1969260 chr2:85568810 C/T cg24342717 chr2:85555507 TGOLN2 -0.51 -7.32 -0.37 1.98e-12 Ear protrusion; CRC cis rs7546094 1.000 rs6682737 chr1:113136229 T/C cg22162597 chr1:113214053 CAPZA1 0.43 6.08 0.32 3.3e-9 Platelet distribution width; CRC cis rs12142240 0.698 rs17361950 chr1:46864150 C/T cg00530320 chr1:46809349 NSUN4 0.57 7.37 0.38 1.41e-12 Menopause (age at onset); CRC cis rs2251381 0.750 rs8129616 chr21:30520085 C/T cg24692254 chr21:30365293 RNF160 -0.73 -12.03 -0.55 6.87e-28 Selective IgA deficiency; CRC cis rs4319547 0.614 rs10846764 chr12:122874297 T/C cg23029597 chr12:123009494 RSRC2 0.59 7.19 0.37 4.35e-12 Body mass index; CRC cis rs67478160 0.584 rs2295147 chr14:104195664 A/G cg08213375 chr14:104286397 PPP1R13B -0.53 -10.82 -0.51 1.48e-23 Schizophrenia; CRC trans rs9858542 0.953 rs7648841 chr3:49416825 G/A cg21659725 chr3:3221576 CRBN -0.63 -8.62 -0.43 2.85e-16 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC trans rs11825064 0.549 rs56167774 chr11:134487221 G/T cg00033773 chr19:12779366 MORG1;C19orf56 0.44 5.96 0.31 6.52e-9 Seasonality; CRC cis rs7923609 0.967 rs10509186 chr10:65207018 C/T cg08743896 chr10:65200160 JMJD1C -0.42 -6.12 -0.32 2.62e-9 Educational attainment;Liver enzyme levels (alkaline phosphatase); CRC cis rs9462027 0.630 rs2744943 chr6:34643179 A/G cg07306190 chr6:34760872 UHRF1BP1 -0.35 -6.32 -0.33 8.5e-10 Systemic lupus erythematosus; CRC cis rs9818758 0.607 rs56306491 chr3:49314960 G/A cg00383909 chr3:49044727 WDR6 1.38 12.29 0.56 7.97e-29 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; CRC cis rs1065852 0.526 rs9623490 chr22:42398266 G/C cg00645731 chr22:42541494 CYP2D7P1 0.4 6.86 0.35 3.42e-11 Response to serotonin reuptake inhibitors in major depressive disorder (plasma drug and metabolite levels); CRC cis rs1552244 1.000 rs7628448 chr3:10146828 G/A cg00166722 chr3:10149974 C3orf24 0.7 9.04 0.45 1.37e-17 Alzheimer's disease; CRC cis rs4243830 0.737 rs56036909 chr1:6608503 C/T cg22792644 chr1:6614718 TAS1R1;NOL9 0.94 10.76 0.51 2.5e-23 Body mass index; CRC cis rs992157 0.735 rs2271541 chr2:219082119 G/T cg00012203 chr2:219082015 ARPC2 0.62 10.46 0.5 2.7e-22 Colorectal cancer; CRC cis rs9916302 0.706 rs12937013 chr17:37665571 G/A cg00129232 chr17:37814104 STARD3 -0.58 -7.26 -0.37 2.74e-12 Glomerular filtration rate (creatinine); CRC cis rs13315871 0.929 rs76226186 chr3:58318499 C/T cg20936604 chr3:58311152 NA -0.75 -7.03 -0.36 1.18e-11 Cholesterol, total; CRC cis rs992157 0.560 rs10932763 chr2:219085863 G/C cg00012203 chr2:219082015 ARPC2 -0.54 -8.52 -0.43 5.77e-16 Colorectal cancer; CRC cis rs61021925 1 rs61021925 chr12:122863659 T/C cg23029597 chr12:123009494 RSRC2 0.43 6.16 0.32 2.16e-9 Schizophrenia; CRC trans rs9291683 0.509 rs998676 chr4:9948564 T/C cg26043149 chr18:55253948 FECH -0.53 -8.17 -0.41 6.52e-15 Bone mineral density; CRC cis rs875971 0.540 rs736270 chr7:65428822 T/C cg02869306 chr7:64672164 INTS4L1 -0.38 -6.15 -0.32 2.18e-9 Aortic root size; CRC cis rs4638749 0.677 rs13414687 chr2:108806245 A/G cg25838818 chr2:108905173 SULT1C2 -0.34 -5.78 -0.3 1.7e-8 Blood pressure; CRC cis rs4561483 0.583 rs1019814 chr16:11940764 T/C cg08843971 chr16:11963173 GSPT1 0.5 7.63 0.39 2.52e-13 Testicular germ cell tumor; CRC cis rs889312 0.500 rs832577 chr5:56163787 G/A cg24531977 chr5:56204891 C5orf35 -0.44 -6.65 -0.34 1.26e-10 Breast cancer;Breast cancer (early onset); CRC cis rs6502050 0.799 rs8066370 chr17:80102105 T/C cg11859384 chr17:80120422 CCDC57 -0.37 -5.85 -0.31 1.16e-8 Life satisfaction; CRC cis rs6694270 0.913 rs3935030 chr1:19116956 C/T cg26220594 chr1:19110978 NA -0.46 -6.68 -0.35 1e-10 Drug-induced liver injury (nitrofurantoin); CRC cis rs853679 0.824 rs34712084 chr6:28043828 A/G cg06470822 chr6:28175283 NA 0.83 6.79 0.35 5.23e-11 Depression; CRC trans rs1814175 0.645 rs1963215 chr11:49931486 G/A cg03929089 chr4:120376271 NA -0.91 -16.07 -0.66 2.65e-43 Height; CRC cis rs6456156 0.742 rs6456157 chr6:167527818 C/A cg07513332 chr6:167530253 CCR6 -0.44 -8.09 -0.41 1.14e-14 Primary biliary cholangitis; CRC cis rs7246657 0.943 rs4802766 chr19:37981933 T/C cg23950597 chr19:37808831 NA -0.52 -6.15 -0.32 2.22e-9 Coronary artery calcification; CRC cis rs910316 1.000 rs10146482 chr14:75574087 C/T cg08847533 chr14:75593920 NEK9 0.94 18.72 0.72 9.55e-54 Height; CRC trans rs2797160 1.000 rs9401843 chr6:126004124 T/C cg05039488 chr6:79577232 IRAK1BP1 -0.49 -7.2 -0.37 4.18e-12 Endometrial cancer; CRC cis rs832187 0.704 rs832195 chr3:63864612 T/C cg16258503 chr3:63850278 ATXN7;THOC7 0.44 6.16 0.32 2.16e-9 Schizophrenia; CRC trans rs1814175 0.502 rs12365889 chr11:49623034 G/A cg15704280 chr7:45808275 SEPT13 -0.78 -10.83 -0.51 1.44e-23 Height; CRC cis rs1552244 1.000 rs17032268 chr3:10067972 C/T cg02579736 chr3:10068473 FANCD2;CIDECP 0.95 12.63 0.57 4.38e-30 Alzheimer's disease; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg00011284 chr16:53469344 RBL2 0.49 6.46 0.34 3.83e-10 Thyroid stimulating hormone; CRC cis rs10911251 0.546 rs1062044 chr1:183112412 A/G ch.1.3577855R chr1:183094577 LAMC1 0.83 14.65 0.63 9.3e-38 Colorectal cancer; CRC cis rs4819052 0.724 rs1304487 chr21:46657283 C/G cg02159808 chr21:46707872 POFUT2;LOC642852 -0.46 -6.26 -0.33 1.2e-9 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs7659604 0.676 rs7691955 chr4:122700462 A/T cg20573242 chr4:122745356 CCNA2 0.51 7.38 0.38 1.34e-12 Type 2 diabetes; CRC cis rs12142240 0.698 rs1053628 chr1:46827769 C/T cg00530320 chr1:46809349 NSUN4 0.59 8.17 0.41 6.78e-15 Menopause (age at onset); CRC trans rs1656966 1.000 rs1656966 chr3:186466252 C/T cg14905632 chr17:38333933 RAPGEFL1 0.4 6.23 0.32 1.45e-9 Myopia (pathological); CRC cis rs58688157 0.924 rs35865896 chr11:584591 A/G cg01842473 chr11:617407 IRF7;MUPCDH -0.66 -9.13 -0.45 7.13e-18 Systemic lupus erythematosus; CRC cis rs7224737 0.956 rs8081327 chr17:40274200 G/A cg02228675 chr17:40259724 DHX58 -0.49 -6.91 -0.36 2.6e-11 Fibrinogen levels; CRC cis rs9875589 0.509 rs11128679 chr3:14075245 C/T cg14375111 chr3:14165186 TMEM43;CHCHD4 0.42 6.48 0.34 3.34e-10 Ovarian reserve; CRC cis rs2760061 0.626 rs634106 chr1:228121548 C/T cg02753203 chr1:228287806 NA -0.65 -10.01 -0.48 9.07e-21 Diastolic blood pressure; CRC cis rs6445967 1.000 rs7640866 chr3:58288362 A/G cg23715586 chr3:58305044 RPP14 0.35 5.87 0.31 1.09e-8 Platelet count; CRC cis rs12701220 0.655 rs7784403 chr7:1153077 G/A cg06145435 chr7:1022769 CYP2W1 0.38 5.99 0.31 5.37e-9 Bronchopulmonary dysplasia; CRC cis rs9925964 0.622 rs8046707 chr16:30916233 G/A cg03418659 chr16:31128414 MYST1 0.43 6.18 0.32 1.89e-9 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs7524258 0.868 rs2412152 chr1:7303213 C/T cg07173049 chr1:7289937 CAMTA1 0.6 9.83 0.48 3.69e-20 Tourette's syndrome or obsessive-compulsive disorder; CRC cis rs904251 0.580 rs62408367 chr6:37444813 G/A cg25019722 chr6:37503610 NA -0.35 -6.07 -0.32 3.49e-9 Cognitive performance; CRC cis rs11098499 0.954 rs1022145 chr4:120230979 A/G cg09307838 chr4:120376055 NA 0.68 10.28 0.49 1.09e-21 Corneal astigmatism; CRC trans rs116095464 0.558 rs1812843 chr5:267658 A/G cg00938859 chr5:1591904 SDHAP3 0.74 7.95 0.4 3.03e-14 Breast cancer; CRC cis rs7591163 1.000 rs1721359 chr2:228751874 C/T cg21577049 chr2:228736449 WDR69 -0.44 -5.84 -0.31 1.24e-8 Blood pressure; CRC cis rs875971 0.862 rs2909688 chr7:65841612 C/A cg11764359 chr7:65958608 NA 0.57 8.45 0.42 9.33e-16 Aortic root size; CRC cis rs12451471 0.620 rs11150846 chr17:78098520 C/T cg12100956 chr17:78086420 GAA -0.36 -5.62 -0.3 4e-8 Plateletcrit;Mean corpuscular hemoglobin concentration; CRC cis rs9914988 0.943 rs34693224 chr17:27079555 C/T cg12682573 chr17:27188876 MIR451;MIR144 0.57 7.85 0.4 5.82e-14 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs3020333 0.875 rs2982573 chr6:152010534 A/G cg22157087 chr6:152012887 ESR1 0.53 8.06 0.41 1.41e-14 Total body bone mineral density; CRC cis rs7772486 0.720 rs991507 chr6:146023609 G/A cg05347473 chr6:146136440 FBXO30 -0.38 -5.81 -0.3 1.51e-8 Lobe attachment (rater-scored or self-reported); CRC trans rs11098499 0.863 rs11736416 chr4:120431661 C/T cg25214090 chr10:38739885 LOC399744 0.63 9.85 0.48 3.24e-20 Corneal astigmatism; CRC cis rs12024301 0.557 rs12049175 chr1:183625562 T/C cg11505048 chr1:183622726 RGL1;APOBEC4 0.78 6.93 0.36 2.18e-11 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs1878931 0.580 rs4785932 chr16:3410456 C/G cg26668626 chr16:3451006 ZNF174;ZNF434 0.89 14.33 0.62 1.64e-36 Body mass index (adult); CRC cis rs4819052 0.851 rs2236444 chr21:46678226 T/C cg02159808 chr21:46707872 POFUT2;LOC642852 0.54 7.1 0.36 7.8e-12 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs6968419 0.747 rs12670683 chr7:115874466 T/C cg02561103 chr7:115862891 TES -0.42 -6.28 -0.33 1.09e-9 Intraocular pressure; CRC cis rs2242116 0.727 rs10865943 chr3:46969970 T/C cg02527881 chr3:46936655 PTH1R -0.52 -9.98 -0.48 1.14e-20 Birth weight; CRC cis rs8180040 0.932 rs1531875 chr3:47452786 G/A cg02527881 chr3:46936655 PTH1R -0.39 -7.47 -0.38 7.17e-13 Colorectal cancer; CRC cis rs12477438 0.765 rs13406288 chr2:99589585 T/C cg26064155 chr2:99771622 LIPT1;TSGA10 -0.63 -8.56 -0.43 4.4e-16 Chronic sinus infection; CRC cis rs7412746 0.634 rs3754212 chr1:150738200 A/G cg10589385 chr1:150898437 SETDB1 0.31 6.34 0.33 7.79e-10 Melanoma; CRC cis rs854765 0.505 rs4924832 chr17:17897739 A/G cg24612305 chr17:17875800 TOM1L2;LRRC48 0.73 12.89 0.58 4.74e-31 Total body bone mineral density; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg10217975 chr3:52091484 DUSP7 -0.4 -6.26 -0.33 1.22e-9 Myopia (pathological); CRC cis rs8060686 0.858 rs10468274 chr16:67922342 C/T cg26727032 chr16:67993705 SLC12A4 -0.71 -11.47 -0.53 7.86e-26 HDL cholesterol;Metabolic syndrome; CRC cis rs10504229 1.000 rs73609764 chr8:58192971 G/A cg02725872 chr8:58115012 NA -0.38 -6.43 -0.33 4.44e-10 Developmental language disorder (linguistic errors); CRC cis rs62229266 0.835 rs998384 chr21:37445526 G/C cg12218747 chr21:37451666 NA -0.43 -7.3 -0.37 2.22e-12 Mitral valve prolapse; CRC cis rs921968 0.608 rs658378 chr2:219483881 T/A cg02176678 chr2:219576539 TTLL4 0.48 7.65 0.39 2.26e-13 Mean corpuscular hemoglobin concentration; CRC trans rs4853036 0.502 rs6717068 chr2:70009641 A/T cg14633329 chr9:139640053 LCN6 -0.39 -6.44 -0.33 4.31e-10 Colorectal or endometrial cancer; CRC cis rs6502050 0.835 rs9902485 chr17:80093701 C/T cg13198984 chr17:80129470 CCDC57 0.46 8.15 0.41 7.78e-15 Life satisfaction; CRC cis rs10751667 0.643 rs10902237 chr11:944801 C/A cg23136738 chr11:925521 AP2A2 -0.42 -6.84 -0.35 3.78e-11 Alzheimer's disease (late onset); CRC cis rs11098499 0.954 rs10006525 chr4:120408931 T/G cg09307838 chr4:120376055 NA 0.7 11.04 0.52 2.47e-24 Corneal astigmatism; CRC cis rs1784581 0.588 rs9458428 chr6:162424579 A/G cg17173639 chr6:162384350 PARK2 -0.59 -9.5 -0.46 4.66e-19 Itch intensity from mosquito bite; CRC trans rs9630182 0.561 rs307246 chr11:13483227 A/G cg13741668 chr9:85679694 NA 0.37 6.0 0.31 5.31e-9 Bone mineral density; CRC cis rs919433 0.963 rs13033821 chr2:198173536 T/G cg03934865 chr2:198174659 NA -0.46 -7.07 -0.36 9.19e-12 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC cis rs7927771 0.864 rs7937331 chr11:47430458 T/C cg18512352 chr11:47633146 NA 0.36 7.07 0.36 9.23e-12 Subjective well-being; CRC cis rs3806843 1.000 rs1548701 chr5:140164557 T/C cg19875535 chr5:140030758 IK 0.6 9.79 0.47 5.14e-20 Depressive symptoms (multi-trait analysis); CRC cis rs6088580 0.634 rs6088484 chr20:32985961 T/C cg08999081 chr20:33150536 PIGU -0.61 -11.52 -0.54 4.84e-26 Glomerular filtration rate (creatinine); CRC trans rs1814175 0.647 rs4881649 chr11:49845560 A/G cg21153622 chr11:89784906 NA -0.43 -7.15 -0.37 5.51e-12 Height; CRC cis rs13217239 0.621 rs12527231 chr6:27001288 G/A cg18867708 chr6:26865862 GUSBL1 0.37 5.67 0.3 3.09e-8 Schizophrenia; CRC cis rs6835098 0.924 rs13125240 chr4:174151619 T/C cg08422745 chr4:174089978 GALNT7 0.94 14.15 0.62 7.8e-36 Dementia and core Alzheimer's disease neuropathologic changes; CRC cis rs17125944 0.686 rs7143400 chr14:53324891 A/C cg00686598 chr14:53173677 PSMC6 -0.66 -6.21 -0.32 1.56e-9 Alzheimer's disease (late onset); CRC cis rs1691799 0.867 rs1039056 chr12:66760391 C/T cg16791601 chr12:66731901 HELB -0.72 -12.62 -0.57 4.66e-30 White blood cell count (basophil); CRC cis rs4268898 0.735 rs12469585 chr2:24489054 A/T cg06627628 chr2:24431161 ITSN2 0.43 6.13 0.32 2.51e-9 Asthma; CRC cis rs6938 0.514 rs35556055 chr15:75253414 G/A cg09165964 chr15:75287851 SCAMP5 0.54 8.01 0.4 2.02e-14 Breast cancer; CRC cis rs4665809 0.652 rs2241739 chr2:26411894 C/T cg25036284 chr2:26402008 FAM59B -0.65 -8.64 -0.43 2.47e-16 Gut microbiome composition (summer); CRC cis rs1448094 0.511 rs34656916 chr12:86154658 G/C cg25456477 chr12:86230367 RASSF9 0.39 6.45 0.34 3.89e-10 Major depressive disorder; CRC cis rs853679 0.545 rs35949109 chr6:28025926 T/C cg19041857 chr6:27730383 NA -0.59 -5.65 -0.3 3.41e-8 Depression; CRC cis rs853679 0.517 rs35193936 chr6:28076270 A/G cg02683197 chr6:28174875 NA 0.82 10.05 0.48 6.9e-21 Depression; CRC cis rs11155671 0.530 rs7757984 chr6:150208651 A/G cg07701084 chr6:150067640 NUP43 0.49 7.08 0.36 8.73e-12 Testicular germ cell tumor; CRC trans rs12599106 0.770 rs12445057 chr16:34970274 C/G cg07332563 chr6:291687 DUSP22 -0.59 -8.39 -0.42 1.44e-15 Menopause (age at onset); CRC cis rs11924390 0.800 rs1648698 chr3:186449582 G/C cg04611788 chr3:186434169 KNG1 -0.57 -8.32 -0.42 2.41e-15 Adiponectin levels; CRC cis rs72781680 0.821 rs12623521 chr2:24181670 C/T cg08917208 chr2:24149416 ATAD2B 0.57 6.82 0.35 4.39e-11 Lymphocyte counts; CRC cis rs1572438 0.929 rs9378520 chr6:861685 C/T cg21062780 chr6:887772 NA -0.4 -6.09 -0.32 3.22e-9 Aging; CRC cis rs270601 0.710 rs371709 chr5:131583240 A/G cg02033258 chr5:131593261 PDLIM4 0.49 8.55 0.43 4.86e-16 Acylcarnitine levels; CRC cis rs11945232 1.000 rs28406846 chr4:88343468 C/G cg23841344 chr4:88312519 HSD17B11 -0.52 -6.76 -0.35 6.46e-11 Intelligence (multi-trait analysis); CRC cis rs172166 0.694 rs1225716 chr6:28113746 A/C cg23161317 chr6:28129485 ZNF389 0.46 6.42 0.33 4.71e-10 Cardiac Troponin-T levels; CRC cis rs4925386 0.840 rs6142738 chr20:60919960 C/T cg15193198 chr20:60906057 LAMA5 0.39 5.91 0.31 8.76e-9 Colorectal cancer;Colorectal cancer (SNP x SNP interaction); CRC cis rs2228479 0.717 rs17226274 chr16:89850170 C/T cg19635926 chr16:89946313 TCF25 0.6 5.68 0.3 3.04e-8 Skin colour saturation; CRC cis rs9640161 0.659 rs11974980 chr7:150009838 C/T cg13722127 chr7:150037890 RARRES2 0.46 7.49 0.38 6.43e-13 Blood protein levels;Circulating chemerin levels; CRC cis rs7412746 0.658 rs12405726 chr1:150956128 G/A cg17724175 chr1:150552817 MCL1 0.47 6.89 0.36 2.81e-11 Melanoma; CRC cis rs1552244 1.000 rs1552244 chr3:10135577 A/G cg00166722 chr3:10149974 C3orf24 0.62 8.39 0.42 1.44e-15 Alzheimer's disease; CRC cis rs4713118 0.869 rs9283882 chr6:27715258 A/C cg21251018 chr6:28226885 NKAPL 0.38 5.74 0.3 2.13e-8 Parkinson's disease; CRC cis rs2735413 0.709 rs4395084 chr16:78088011 C/G cg04733911 chr16:78082701 NA -0.42 -6.69 -0.35 9.9e-11 Systolic blood pressure (alcohol consumption interaction); CRC cis rs2153535 0.580 rs7745043 chr6:8513507 T/C cg07606381 chr6:8435919 SLC35B3 0.65 10.53 0.5 1.58e-22 Motion sickness; CRC cis rs501120 0.584 rs11238927 chr10:44704112 C/T cg09554077 chr10:44749378 NA 0.67 7.47 0.38 7.27e-13 Coronary artery disease;Coronary heart disease; CRC cis rs644799 0.544 rs1527450 chr11:95467777 G/T cg25622487 chr11:95524042 FAM76B;CEP57 0.51 7.13 0.37 6.6e-12 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs9814567 0.806 rs55835132 chr3:134325256 T/G cg06109529 chr3:134205091 CEP63;ANAPC13 -0.68 -10.11 -0.49 4.11e-21 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs7727544 0.735 rs4705933 chr5:131678412 G/A cg24060327 chr5:131705240 SLC22A5 -0.37 -6.09 -0.32 3.09e-9 Blood metabolite levels; CRC cis rs6748734 0.779 rs4401206 chr2:241796905 A/G cg04034577 chr2:241836375 C2orf54 -0.35 -7.47 -0.38 7.51e-13 Urinary metabolites; CRC cis rs6563739 0.655 rs10467367 chr13:40227072 A/G cg00026919 chr13:40226031 NA 0.47 5.85 0.31 1.17e-8 Menarche (age at onset); CRC cis rs7113874 0.569 rs1446463 chr11:8566329 G/A cg20771178 chr11:8615675 STK33 -0.36 -5.89 -0.31 9.43e-9 Body mass index in physically active individuals;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs10876993 0.928 rs774890 chr12:58068388 C/T cg18357645 chr12:58087776 OS9 0.59 8.3 0.42 2.71e-15 Celiac disease or Rheumatoid arthritis; CRC cis rs4713118 0.516 rs4713142 chr6:28106347 T/G cg15845792 chr6:28175446 NA 1.01 13.54 0.6 1.59e-33 Parkinson's disease; CRC cis rs7605827 0.930 rs1996517 chr2:15517330 T/C cg19274914 chr2:15703543 NA 0.39 5.93 0.31 7.51e-9 Educational attainment (years of education); CRC cis rs1552244 1.000 rs7615646 chr3:10089773 A/C cg00166722 chr3:10149974 C3orf24 0.7 9.53 0.46 3.69e-19 Alzheimer's disease; CRC cis rs17125944 0.686 rs12435704 chr14:53346574 T/C cg00686598 chr14:53173677 PSMC6 -0.63 -5.78 -0.3 1.71e-8 Alzheimer's disease (late onset); CRC trans rs9393777 0.778 rs13219354 chr6:27185664 T/C cg06606381 chr12:133084897 FBRSL1 -0.9 -6.95 -0.36 1.93e-11 Intelligence (multi-trait analysis); CRC trans rs17685 0.753 rs1104878 chr7:75685593 G/T cg19862616 chr7:65841803 NCRNA00174 0.99 18.63 0.72 2.21e-53 Coffee consumption;Coffee consumption (cups per day); CRC cis rs9649213 0.593 rs7789380 chr7:97956180 G/A cg00277769 chr7:97922759 BAIAP2L1 -0.61 -10.65 -0.51 5.96e-23 Prostate cancer (SNP x SNP interaction); CRC trans rs2303319 0.504 rs12476631 chr2:162566936 A/G cg12500891 chr11:57225987 NA -0.67 -6.04 -0.32 4.19e-9 Cognitive function; CRC cis rs4820539 1.000 rs4822362 chr22:23482744 C/A cg14186256 chr22:23484241 RTDR1 0.9 17.78 0.7 4.91e-50 Bone mineral density; CRC cis rs1419980 0.586 rs10845548 chr12:7777657 T/A cg10578777 chr12:7781093 NA -0.46 -6.16 -0.32 2.16e-9 HDL cholesterol levels; CRC cis rs6964587 1.000 rs2188154 chr7:91595138 T/A cg17063962 chr7:91808500 NA 0.81 14.19 0.62 5.71e-36 Breast cancer; CRC cis rs4638749 0.734 rs35184015 chr2:108870540 C/T cg25838818 chr2:108905173 SULT1C2 -0.34 -5.78 -0.3 1.71e-8 Blood pressure; CRC cis rs2032447 0.901 rs2213284 chr6:26031868 G/A cg03517284 chr6:25882590 NA -0.52 -7.11 -0.37 7.08e-12 Intelligence (multi-trait analysis); CRC cis rs654950 0.934 rs665223 chr1:42000654 A/T cg06885757 chr1:42089581 HIVEP3 -0.39 -6.41 -0.33 5.18e-10 Airway imaging phenotypes; CRC cis rs10193935 0.901 rs222471 chr2:42638057 C/T cg27598129 chr2:42591480 NA 0.64 7.51 0.38 5.53e-13 Colonoscopy-negative controls vs population controls; CRC cis rs12586317 0.557 rs72664863 chr14:35643588 C/T cg07166546 chr14:35805898 NA -0.31 -5.95 -0.31 6.89e-9 Psoriasis; CRC cis rs11608355 0.545 rs6606723 chr12:109905044 C/G cg05360138 chr12:110035743 NA 0.77 8.7 0.43 1.65e-16 Neuroticism; CRC cis rs1953600 0.870 rs12770550 chr10:81953451 G/T cg00277334 chr10:82204260 NA 0.36 5.86 0.31 1.11e-8 Sarcoidosis; CRC cis rs919433 1.000 rs2195510 chr2:198161195 A/G cg10820045 chr2:198174542 NA -0.57 -11.46 -0.53 8.38e-26 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC cis rs13064411 0.696 rs13066742 chr3:113208423 T/C cg10517650 chr3:113235015 CCDC52 -0.4 -6.97 -0.36 1.73e-11 Response to simvastatin treatment (PCSK9 protein level change); CRC cis rs2243480 0.708 rs35825036 chr7:65986502 T/C cg12463550 chr7:65579703 CRCP 0.68 6.13 0.32 2.58e-9 Diabetic kidney disease; CRC cis rs10504229 0.683 rs6982990 chr8:58115275 C/T cg02290350 chr8:58132656 NA 0.53 7.74 0.39 1.27e-13 Developmental language disorder (linguistic errors); CRC cis rs6429082 0.967 rs834143 chr1:235626406 C/T cg26050004 chr1:235667680 B3GALNT2 0.46 6.74 0.35 7.13e-11 Adiposity; CRC cis rs1448094 0.967 rs2405789 chr12:86320466 C/T cg18827107 chr12:86230957 RASSF9 0.37 6.11 0.32 2.76e-9 Major depressive disorder; CRC cis rs7246657 0.823 rs4802236 chr19:37919246 A/G cg23950597 chr19:37808831 NA -0.54 -6.51 -0.34 2.82e-10 Coronary artery calcification; CRC cis rs3087591 0.919 rs2072131 chr17:29559588 G/C cg24425628 chr17:29625626 OMG;NF1 -0.86 -16.4 -0.67 1.31e-44 Hip circumference; CRC trans rs7726839 0.540 rs58599998 chr5:596087 A/G cg25482853 chr8:67687455 SGK3 1.09 12.84 0.58 7.36e-31 Obesity-related traits; CRC cis rs7772486 0.754 rs697055 chr6:146003790 C/G cg13319975 chr6:146136371 FBXO30 -0.43 -6.21 -0.32 1.64e-9 Lobe attachment (rater-scored or self-reported); CRC trans rs8123881 0.733 rs7268466 chr20:15810676 C/T cg00292047 chr11:33279899 HIPK3 0.6 6.36 0.33 6.86e-10 Body mass index; CRC cis rs875971 0.862 rs4718319 chr7:65652784 C/A cg00343986 chr7:65444356 GUSB -0.42 -5.98 -0.31 5.8e-9 Aortic root size; CRC trans rs2303319 0.504 rs62189047 chr2:162613314 T/A cg27342122 chr8:133787442 PHF20L1 -0.72 -6.12 -0.32 2.68e-9 Cognitive function; CRC cis rs6540559 1.000 rs742214 chr1:209960925 T/C cg25204440 chr1:209979598 IRF6 0.48 6.32 0.33 8.36e-10 Cleft lip with or without cleft palate; CRC cis rs2120019 0.938 rs3850093 chr15:75318482 A/G cg09165964 chr15:75287851 SCAMP5 0.88 12.45 0.57 1.97e-29 Blood trace element (Zn levels); CRC cis rs2717559 0.683 rs2717611 chr8:143879927 C/T cg12516270 chr8:143859308 LYNX1 -0.51 -9.26 -0.45 2.68e-18 Urinary tract infection frequency; CRC trans rs916888 0.773 rs169201 chr17:44790203 A/G cg01341218 chr17:43662625 NA 1.01 10.65 0.51 5.9e-23 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs7739232 0.920 rs79752040 chr6:53527285 A/G cg15658676 chr6:53530538 KLHL31 -0.76 -5.9 -0.31 8.9e-9 Hip circumference adjusted for BMI; CRC cis rs41271473 0.526 rs10916344 chr1:228737489 C/T cg16512390 chr1:228756714 NA 0.63 7.2 0.37 4.15e-12 Chronic lymphocytic leukemia; CRC cis rs7120118 0.517 rs12221497 chr11:47280653 G/A cg25783544 chr11:47291846 MADD 0.64 5.77 0.3 1.85e-8 HDL cholesterol; CRC cis rs4604732 0.536 rs12037221 chr1:247631212 T/C cg12758973 chr1:247694275 LOC148824;OR2C3 0.37 5.66 0.3 3.3e-8 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CRC cis rs2370759 1.000 rs16933225 chr10:32599464 C/T cg01819863 chr10:32635814 EPC1 1.04 12.15 0.56 2.49e-28 Sexual dysfunction (female); CRC cis rs853679 0.517 rs9368551 chr6:28061792 A/G cg06470822 chr6:28175283 NA 1.0 13.31 0.59 1.27e-32 Depression; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg16273041 chr11:47600972 KBTBD4;NDUFS3 0.43 6.29 0.33 1.03e-9 Response to antipsychotic treatment; CRC cis rs12594515 1.000 rs8033148 chr15:45997929 G/A cg19682013 chr15:45996608 NA 0.32 6.6 0.34 1.6e-10 Waist circumference;Weight; CRC cis rs709400 0.663 rs8015918 chr14:103942991 A/G cg12935359 chr14:103987150 CKB -0.49 -7.93 -0.4 3.42e-14 Body mass index; CRC cis rs7113874 0.589 rs10840051 chr11:8475180 G/C cg02811074 chr11:8615871 STK33 -0.35 -6.04 -0.32 4.16e-9 Body mass index in physically active individuals;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs2836974 0.644 rs2410123 chr21:40700093 C/T cg17971929 chr21:40555470 PSMG1 -0.63 -9.14 -0.45 6.47e-18 Cognitive function; CRC cis rs1799949 1.000 rs3950989 chr17:41237953 G/A cg25072359 chr17:41440525 NA 0.46 6.86 0.35 3.39e-11 Menopause (age at onset); CRC cis rs853679 0.517 rs11552219 chr6:28126834 C/T cg15845792 chr6:28175446 NA 1.04 13.89 0.61 7.67e-35 Depression; CRC cis rs2075371 0.933 rs1901214 chr7:133945108 C/T cg02659138 chr7:134003124 SLC35B4 -0.37 -6.39 -0.33 5.56e-10 Mean platelet volume; CRC cis rs1953600 0.870 rs2789690 chr10:81938204 G/T cg04850286 chr10:81895943 PLAC9 0.38 6.72 0.35 7.9e-11 Sarcoidosis; CRC trans rs9329221 0.572 rs4841295 chr8:10105115 C/T cg16141378 chr3:129829833 LOC729375 -0.44 -6.51 -0.34 2.81e-10 Neuroticism; CRC cis rs1572438 0.929 rs9378520 chr6:861685 C/T cg13447295 chr6:887704 NA -0.46 -6.39 -0.33 5.61e-10 Aging; CRC trans rs629535 0.814 rs62513376 chr8:70086881 C/T cg21567404 chr3:27674614 NA -0.91 -14.64 -0.63 9.67e-38 Dupuytren's disease; CRC cis rs1008375 1.000 rs10939744 chr4:17664473 G/T cg04450456 chr4:17643702 FAM184B 0.42 6.62 0.34 1.49e-10 Parasitemia in Tripanosoma cruzi seropositivity; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg10067538 chr16:87351824 NA 0.31 5.97 0.31 6.01e-9 Response to antipsychotic treatment; CRC cis rs863345 0.564 rs34701257 chr1:158480955 A/G cg12129480 chr1:158549410 OR10X1 -0.3 -6.24 -0.33 1.32e-9 Pneumococcal bacteremia; CRC trans rs7615952 0.546 rs2979307 chr3:125309574 C/T cg02560186 chr11:3602584 NA 0.54 6.98 0.36 1.68e-11 Blood pressure (smoking interaction); CRC cis rs7258465 1.000 rs10425982 chr19:18586519 T/A cg06953865 chr19:18549723 ISYNA1 -0.38 -5.76 -0.3 1.89e-8 Breast cancer; CRC trans rs11098499 0.954 rs9993199 chr4:120392873 A/G cg25214090 chr10:38739885 LOC399744 -0.63 -10.17 -0.49 2.67e-21 Corneal astigmatism; CRC cis rs5997397 0.967 rs5752791 chr22:29153547 A/G cg15103426 chr22:29168792 CCDC117 -0.38 -5.64 -0.3 3.6e-8 Red cell distribution width; CRC cis rs2153535 0.580 rs969422 chr6:8451780 A/T cg07606381 chr6:8435919 SLC35B3 0.68 10.85 0.51 1.2e-23 Motion sickness; CRC cis rs911119 0.913 rs12710327 chr20:23569689 C/T cg16589663 chr20:23618590 CST3 0.42 5.89 0.31 9.32e-9 Chronic kidney disease; CRC trans rs11722228 1.000 rs6823877 chr4:9921931 T/C cg26043149 chr18:55253948 FECH -0.72 -10.42 -0.5 3.67e-22 Gout;Urate levels;Serum uric acid levels; CRC trans rs11026407 0.967 rs7127246 chr11:22060228 C/G cg15586341 chr10:73899798 ASCC1 -0.61 -6.6 -0.34 1.64e-10 Plasma thyroid-stimulating hormone levels; CRC cis rs1165668 0.816 rs1866069 chr12:104310545 G/T cg21863207 chr12:104234989 NT5DC3 -0.43 -6.47 -0.34 3.5e-10 Coronary heart disease (SNP X SNP interaction); CRC cis rs1059312 0.778 rs4760594 chr12:129296865 T/A cg09035930 chr12:129282057 SLC15A4 0.54 9.02 0.45 1.58e-17 Systemic lupus erythematosus; CRC cis rs10540 1.000 rs35874808 chr11:506442 G/T cg08200582 chr11:442649 ANO9 -0.71 -7.42 -0.38 1.04e-12 Body mass index; CRC cis rs939584 0.825 rs13028252 chr2:632529 T/C cg03610516 chr2:642275 NA 0.42 5.64 0.3 3.58e-8 Body mass index; CRC cis rs7659604 1.000 rs28433617 chr4:122664138 C/A cg06713675 chr4:122721982 EXOSC9 -0.39 -6.39 -0.33 5.76e-10 Type 2 diabetes; CRC cis rs6951245 0.935 rs11763765 chr7:1060510 C/T cg21664854 chr7:1097933 C7orf50;GPR146 0.77 8.63 0.43 2.7e-16 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs7580658 0.676 rs4150407 chr2:128049631 C/T cg09760422 chr2:128146352 NA 0.28 5.65 0.3 3.51e-8 Protein C levels; CRC cis rs7659604 0.643 rs6839375 chr4:122663610 G/C cg06713675 chr4:122721982 EXOSC9 -0.4 -6.12 -0.32 2.61e-9 Type 2 diabetes; CRC cis rs7020830 0.898 rs12554874 chr9:37073902 C/T cg14294708 chr9:37120828 ZCCHC7 1.19 24.92 0.81 9.12e-78 Schizophrenia; CRC cis rs6951245 1.000 rs74652290 chr7:1090109 G/A cg08132940 chr7:1081526 C7orf50 -0.54 -5.74 -0.3 2.13e-8 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs7762018 1.000 rs6904601 chr6:170131905 T/G cg24289452 chr6:170231220 NA -0.58 -6.53 -0.34 2.42e-10 Thiazide-induced adverse metabolic effects in hypertensive patients; CRC cis rs4363385 0.693 rs490553 chr1:153033277 A/G cg25856811 chr1:152973957 SPRR3 -0.24 -6.6 -0.34 1.62e-10 Inflammatory skin disease; CRC trans rs10983614 1.000 rs7867776 chr9:120072627 A/G cg21950287 chr19:54385441 PRKCG 0.46 6.47 0.34 3.63e-10 Survival in pancreatic cancer; CRC cis rs1223397 0.938 rs3817741 chr6:13279507 A/G cg21538684 chr6:13274180 PHACTR1 -0.45 -5.71 -0.3 2.48e-8 Blood pressure; CRC cis rs875971 0.545 rs4718335 chr7:65804606 C/T cg03233332 chr7:66118400 NA -0.42 -5.83 -0.31 1.3e-8 Aortic root size; CRC trans rs804280 0.565 rs1466785 chr8:11623456 C/T cg06636001 chr8:8085503 FLJ10661 0.42 6.47 0.34 3.54e-10 Myopia (pathological); CRC cis rs2735413 0.918 rs12925605 chr16:78071715 G/A cg04733911 chr16:78082701 NA -0.42 -6.99 -0.36 1.55e-11 Systolic blood pressure (alcohol consumption interaction); CRC cis rs1448094 0.511 rs61930035 chr12:86153695 G/A cg00310523 chr12:86230176 RASSF9 0.41 6.62 0.34 1.5e-10 Major depressive disorder; CRC cis rs11650494 0.803 rs117801358 chr17:47447950 C/A cg08112188 chr17:47440006 ZNF652 1.24 11.67 0.54 1.4e-26 Prostate cancer; CRC cis rs8103278 1.000 rs7256192 chr19:46338492 G/A cg16681516 chr19:46297285 DMWD 0.38 6.09 0.32 3.12e-9 Coronary artery disease; CRC cis rs1577917 0.655 rs9444352 chr6:86257535 G/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A 0.53 7.47 0.38 7.29e-13 Response to antipsychotic treatment; CRC cis rs4665809 1.000 rs4665819 chr2:26309073 A/G cg22920501 chr2:26401640 FAM59B -0.53 -7.23 -0.37 3.4e-12 Gut microbiome composition (summer); CRC cis rs7552404 0.696 rs1417405 chr1:76457797 T/C cg10523679 chr1:76189770 ACADM 0.69 8.14 0.41 8.53e-15 Blood metabolite levels;Acylcarnitine levels; CRC cis rs801193 0.591 rs2707839 chr7:66193084 A/G cg11764359 chr7:65958608 NA 0.6 9.27 0.46 2.47e-18 Aortic root size; CRC cis rs3796352 1.000 rs13076033 chr3:52898427 T/C cg27565382 chr3:53032988 SFMBT1 0.78 6.26 0.33 1.17e-9 Immune reponse to smallpox (secreted IL-2); CRC trans rs13090388 1 rs13090388 chr3:49391082 C/T cg21665057 chr3:196295764 WDR53;FBXO45 -0.63 -8.47 -0.42 8.46e-16 Intelligence (multi-trait analysis);Educational attainment (years of education); CRC trans rs4378999 0.528 rs2355350 chr3:50814508 G/A cg12383621 chr7:7735611 RPA3 -0.47 -6.01 -0.31 4.92e-9 Waist circumference adjusted for BMI in non-smokers;Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction); CRC cis rs644799 1.000 rs514170 chr11:95556696 C/T cg25622487 chr11:95524042 FAM76B;CEP57 0.76 11.99 0.55 9.59e-28 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs6502050 0.835 rs56095560 chr17:80151304 C/T cg25804541 chr17:80189381 SLC16A3 -0.31 -5.9 -0.31 8.81e-9 Life satisfaction; CRC cis rs9292777 0.518 rs10941515 chr5:40482526 T/A cg09067459 chr5:40385259 NA 0.44 7.33 0.37 1.78e-12 Crohn's disease;Multiple sclerosis; CRC cis rs2836950 0.527 rs2836948 chr21:40599677 T/C cg06238570 chr21:40685208 BRWD1 -0.6 -8.72 -0.43 1.42e-16 Menarche (age at onset); CRC cis rs10504229 0.683 rs35244711 chr8:58117762 T/G cg02725872 chr8:58115012 NA -0.64 -11.55 -0.54 3.85e-26 Developmental language disorder (linguistic errors); CRC cis rs2050392 0.965 rs2265368 chr10:30690289 G/C cg18806716 chr10:30721971 MAP3K8 -0.48 -7.12 -0.37 6.7e-12 Inflammatory bowel disease; CRC cis rs1552244 0.872 rs6803517 chr3:10065426 C/T cg08888203 chr3:10149979 C3orf24 0.69 9.69 0.47 1.04e-19 Alzheimer's disease; CRC cis rs1577917 1.000 rs791856 chr6:86681841 A/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A 0.5 6.82 0.35 4.45e-11 Response to antipsychotic treatment; CRC cis rs13256369 1.000 rs7843488 chr8:8576217 C/T cg06671706 chr8:8559999 CLDN23 0.53 7.45 0.38 8.15e-13 Obesity-related traits; CRC cis rs7647973 1.000 rs6446275 chr3:49466871 A/G cg07636037 chr3:49044803 WDR6 -0.64 -7.59 -0.39 3.33e-13 Menarche (age at onset); CRC cis rs853679 0.517 rs9393901 chr6:28136797 A/G cg15786705 chr6:28176104 NA 0.78 9.83 0.48 3.57e-20 Depression; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg00694336 chr1:114301873 PHTF1 0.47 6.71 0.35 8.68e-11 Intelligence (multi-trait analysis); CRC cis rs9443645 0.901 rs7742034 chr6:79737106 A/G cg09184832 chr6:79620586 NA -0.51 -9.22 -0.45 3.52e-18 Intelligence (multi-trait analysis); CRC cis rs801193 1.000 rs2659915 chr7:66153101 A/G cg11764359 chr7:65958608 NA 0.51 7.95 0.4 2.97e-14 Aortic root size; CRC trans rs208520 0.874 rs208517 chr6:66947040 G/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.92 -11.96 -0.55 1.32e-27 Exhaled nitric oxide output; CRC cis rs7615952 1.000 rs9289275 chr3:125648659 A/T cg05084668 chr3:125655381 ALG1L -0.66 -9.92 -0.48 1.87e-20 Blood pressure (smoking interaction); CRC cis rs6662572 0.737 rs11211206 chr1:46323192 A/G cg08644498 chr1:46502608 NA -0.45 -7.07 -0.36 9.42e-12 Blood protein levels; CRC cis rs4713118 0.505 rs276371 chr6:27910708 A/T cg15845792 chr6:28175446 NA 0.59 8.17 0.41 6.76e-15 Parkinson's disease; CRC cis rs861020 0.630 rs655713 chr1:210006438 C/T cg09163369 chr1:210001066 C1orf107 0.4 5.75 0.3 2.08e-8 Orofacial clefts; CRC cis rs597539 0.652 rs501799 chr11:68631240 G/T cg04772025 chr11:68637568 NA 0.49 7.93 0.4 3.52e-14 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs2280630 0.529 rs784495 chr3:39178899 C/T cg01426195 chr3:39028469 NA 0.42 6.95 0.36 1.93e-11 Verbal declarative memory; CRC trans rs57221529 0.545 rs55955015 chr5:575182 A/G cg11887960 chr12:57824829 NA 0.61 6.67 0.35 1.08e-10 Lung disease severity in cystic fibrosis; CRC cis rs9322193 0.886 rs9322198 chr6:149944908 T/C cg07701084 chr6:150067640 NUP43 0.55 8.04 0.41 1.58e-14 Lung cancer; CRC cis rs1691799 0.899 rs1168292 chr12:66732660 C/T cg16791601 chr12:66731901 HELB -0.67 -11.29 -0.53 3.27e-25 White blood cell count (basophil); CRC cis rs599083 0.502 rs113307519 chr11:68212641 C/T cg16797656 chr11:68205561 LRP5 0.4 5.66 0.3 3.37e-8 Bone mineral density (spine); CRC cis rs478304 0.651 rs78412025 chr11:65495696 T/C cg27068330 chr11:65405492 SIPA1 -0.63 -9.75 -0.47 6.92e-20 Acne (severe); CRC cis rs651907 0.535 rs13085776 chr3:101505507 A/G cg12386194 chr3:101231763 SENP7 0.5 6.89 0.35 2.9e-11 Colorectal cancer; CRC cis rs561341 0.882 rs563539 chr17:30307958 A/G cg19193384 chr17:30244184 NA -0.53 -6.89 -0.36 2.85e-11 Hip circumference adjusted for BMI; CRC cis rs933688 1.000 rs10073935 chr5:90742188 A/G cg02339078 chr5:90679543 LOC100129716;ARRDC3 0.92 14.84 0.63 1.66e-38 Smoking behavior; CRC cis rs67340775 0.541 rs200964 chr6:27866943 G/C cg03623178 chr6:28175578 NA 0.91 9.62 0.47 1.85e-19 Lung cancer in ever smokers; CRC cis rs1552244 1.000 rs2160869 chr3:10079255 G/A cg16606324 chr3:10149918 C3orf24 0.7 9.79 0.48 4.82e-20 Alzheimer's disease; CRC cis rs1707322 1.000 rs4660332 chr1:46461418 T/A cg06784218 chr1:46089804 CCDC17 0.59 10.7 0.51 3.87e-23 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs72781680 0.898 rs72782136 chr2:24047344 A/G cg08917208 chr2:24149416 ATAD2B 0.9 8.87 0.44 4.67e-17 Lymphocyte counts; CRC trans rs1814175 0.935 rs7925863 chr11:49615802 C/A cg15704280 chr7:45808275 SEPT13 -0.97 -17.89 -0.7 1.75e-50 Height; CRC cis rs7605827 0.930 rs7579714 chr2:15686869 A/C cg19274914 chr2:15703543 NA 0.39 5.82 0.31 1.4e-8 Educational attainment (years of education); CRC cis rs7647973 0.626 rs62260723 chr3:49872124 T/C cg03060546 chr3:49711283 APEH -0.66 -8.02 -0.4 1.89e-14 Menarche (age at onset); CRC trans rs1814175 0.817 rs80244685 chr11:49763292 C/A cg15704280 chr7:45808275 SEPT13 -0.95 -16.48 -0.67 6.62e-45 Height; CRC cis rs1355223 0.506 rs7131272 chr11:34869548 A/G cg11058730 chr11:34937778 PDHX;APIP 0.44 6.18 0.32 1.84e-9 Systemic lupus erythematosus and Systemic sclerosis; CRC trans rs2303319 0.504 rs56965753 chr2:162597251 A/G cg04551154 chr10:95462393 C10orf4 -0.75 -6.37 -0.33 6.43e-10 Cognitive function; CRC cis rs394563 0.559 rs7752555 chr6:149671116 A/G cg17885791 chr6:149771845 ZC3H12D 0.31 5.62 0.3 4.13e-8 Dupuytren's disease; CRC cis rs3820928 1.000 rs12615988 chr2:227769000 A/G cg11843606 chr2:227700838 RHBDD1 -0.4 -5.76 -0.3 1.94e-8 Pulmonary function; CRC trans rs4824093 0.610 rs12168949 chr22:50317714 A/G cg09872104 chr7:134855509 C7orf49 -0.75 -6.93 -0.36 2.25e-11 Amyotrophic lateral sclerosis (sporadic); CRC trans rs3942852 0.568 rs7479361 chr11:48109793 C/T cg15704280 chr7:45808275 SEPT13 -0.64 -8.83 -0.44 6.21e-17 Acute lymphoblastic leukemia (childhood); CRC cis rs6951245 0.882 rs10256720 chr7:1210825 C/G cg26224354 chr7:1096374 C7orf50;GPR146 -0.84 -10.87 -0.51 1.02e-23 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC trans rs2228479 0.850 rs62054638 chr16:89821131 G/C cg24644049 chr4:85504048 CDS1 0.86 6.93 0.36 2.29e-11 Skin colour saturation; CRC trans rs73162807 0.655 rs73160985 chr3:146431231 A/G cg26896787 chr1:228603707 TRIM17 -0.59 -5.99 -0.31 5.61e-9 Platelet-derived growth factor BB levels; CRC cis rs1008375 0.932 rs4698627 chr4:17605959 T/C cg16339924 chr4:17578868 LAP3 0.48 6.36 0.33 6.94e-10 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs12900413 0.564 rs8035800 chr15:90314790 T/C cg24249390 chr15:90295951 MESP1 -0.59 -9.61 -0.47 1.93e-19 Coronary artery aneurysm in Kawasaki disease; CRC cis rs10512697 0.803 rs13161713 chr5:3575234 C/G cg19473799 chr5:3511975 NA -0.73 -5.75 -0.3 2.09e-8 Immune response to smallpox vaccine (IL-6); CRC cis rs1129187 0.791 rs1129186 chr6:42932202 C/T cg03790207 chr6:42947109 PEX6 -0.52 -7.68 -0.39 1.85e-13 Alzheimer's disease in APOE e4+ carriers; CRC cis rs823143 0.570 rs823082 chr1:205786935 C/T cg07167872 chr1:205819463 PM20D1 -0.65 -10.35 -0.5 6.62e-22 Monocyte percentage of white cells; CRC cis rs9443645 0.901 rs9448584 chr6:79572799 G/T cg11833968 chr6:79620685 NA -0.36 -6.25 -0.33 1.26e-9 Intelligence (multi-trait analysis); CRC cis rs1218582 0.772 rs877343 chr1:154910012 A/G cg24250549 chr1:154909240 PMVK 0.64 11.02 0.52 3.11e-24 Prostate cancer; CRC cis rs561341 0.783 rs512698 chr17:30292507 G/T cg19193384 chr17:30244184 NA -0.65 -7.48 -0.38 6.75e-13 Hip circumference adjusted for BMI; CRC cis rs11190604 1.000 rs7099965 chr10:102301165 A/G cg07080220 chr10:102295463 HIF1AN 0.47 5.68 0.3 2.96e-8 Palmitoleic acid (16:1n-7) levels; CRC cis rs4588572 0.643 rs10043115 chr5:77692019 T/C cg11446398 chr5:77624930 NA -0.48 -6.71 -0.35 8.6e-11 Triglycerides; CRC cis rs1451375 0.607 rs7807335 chr7:50631862 A/C cg14593290 chr7:50529359 DDC -0.56 -7.24 -0.37 3.15e-12 Malaria; CRC trans rs1814175 0.645 rs28549248 chr11:50042740 C/T cg11707556 chr5:10655725 ANKRD33B -0.52 -10.16 -0.49 2.82e-21 Height; CRC cis rs1046896 0.562 rs2380172 chr17:80887719 C/A cg08200770 chr17:80723486 TBCD -0.43 -6.46 -0.34 3.71e-10 Glycated hemoglobin levels; CRC cis rs9660180 0.967 rs9660106 chr1:1797947 A/G cg05132306 chr1:1846340 CALML6 -0.51 -7.9 -0.4 4.29e-14 Body mass index; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg27183811 chr15:51200847 AP4E1 0.41 6.09 0.32 3.1e-9 Intelligence (multi-trait analysis); CRC cis rs9372498 0.505 rs56406560 chr6:118991787 G/A cg18833306 chr6:118973337 C6orf204 0.47 6.54 0.34 2.32e-10 Diastolic blood pressure; CRC cis rs3733585 0.699 rs6834893 chr4:9959123 C/T cg00071950 chr4:10020882 SLC2A9 -0.54 -9.65 -0.47 1.42e-19 Cleft plate (environmental tobacco smoke interaction); CRC cis rs561341 0.769 rs9899093 chr17:30191954 C/G cg00745463 chr17:30367425 LRRC37B -0.74 -8.15 -0.41 7.68e-15 Hip circumference adjusted for BMI; CRC trans rs3733585 0.753 rs1122141 chr4:9947278 T/C cg26043149 chr18:55253948 FECH -0.5 -7.47 -0.38 7.12e-13 Cleft plate (environmental tobacco smoke interaction); CRC cis rs514406 0.861 rs7526275 chr1:53245849 C/T cg08859206 chr1:53392774 SCP2 0.44 6.74 0.35 7.19e-11 Monocyte count; CRC cis rs6450176 0.638 rs1542167 chr5:53305742 T/G cg22592108 chr5:53304441 ARL15 0.47 5.61 0.3 4.24e-8 HDL cholesterol levels;HDL cholesterol;Adiponectin levels; CRC cis rs1448094 0.533 rs7955135 chr12:86146350 G/A cg00310523 chr12:86230176 RASSF9 -0.36 -5.92 -0.31 8.25e-9 Major depressive disorder; CRC cis rs926938 0.543 rs360600 chr1:115388116 T/C cg12756093 chr1:115239321 AMPD1 0.58 8.5 0.42 6.83e-16 Autism; CRC cis rs9486719 1.000 rs12190397 chr6:97036465 G/A cg18709589 chr6:96969512 KIAA0776 -0.52 -5.83 -0.31 1.3e-8 Migraine;Coronary artery disease; CRC cis rs926938 0.527 rs2335954 chr1:115534151 C/T cg12756093 chr1:115239321 AMPD1 -0.48 -7.12 -0.37 6.82e-12 Autism; CRC cis rs7113874 0.569 rs7104646 chr11:8558841 G/T cg17679104 chr11:8615758 STK33 -0.36 -5.89 -0.31 9.4e-9 Body mass index in physically active individuals;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs1005277 0.579 rs1780133 chr10:38499509 T/C cg03665457 chr10:38645376 HSD17B7P2 -0.42 -5.97 -0.31 5.99e-9 Extrinsic epigenetic age acceleration; CRC cis rs3857536 0.813 rs4710580 chr6:66935200 C/T cg07460842 chr6:66804631 NA -0.43 -5.81 -0.3 1.48e-8 Blood trace element (Cu levels); CRC cis rs7811142 0.943 rs111757992 chr7:100016354 A/C cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.91 12.55 0.57 8.92e-30 Platelet count; CRC cis rs10504229 1.000 rs7007805 chr8:58179327 G/A cg05313129 chr8:58192883 C8orf71 -0.47 -6.99 -0.36 1.49e-11 Developmental language disorder (linguistic errors); CRC cis rs929354 0.772 rs2301914 chr7:157000176 T/C cg17757837 chr7:157058334 UBE3C 0.74 12.63 0.57 4.45e-30 Body mass index; CRC cis rs1799949 1.000 rs4793190 chr17:41200109 T/C cg23758822 chr17:41437982 NA 0.8 13.69 0.6 4.46e-34 Menopause (age at onset); CRC cis rs2404602 0.647 rs12903586 chr15:77168240 G/A cg03037974 chr15:76606532 NA -0.55 -8.22 -0.41 4.88e-15 Blood metabolite levels; CRC cis rs1448094 0.511 rs59858864 chr12:86166404 G/A cg18827107 chr12:86230957 RASSF9 -0.39 -6.01 -0.31 4.81e-9 Major depressive disorder; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg21936789 chr3:47620545 CSPG5 -0.4 -6.39 -0.33 5.79e-10 Myopia (pathological); CRC cis rs1552244 0.872 rs7646073 chr3:10097405 G/A cg08888203 chr3:10149979 C3orf24 0.7 10.01 0.48 8.99e-21 Alzheimer's disease; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg07638098 chr22:30234508 ASCC2 0.45 6.28 0.33 1.06e-9 Response to antipsychotic treatment; CRC cis rs644799 1.000 rs474442 chr11:95583995 A/G cg03916912 chr11:95522834 CEP57;FAM76B 0.94 17.85 0.7 2.5e-50 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs4713118 0.615 rs9295747 chr6:27736993 G/T cg06470822 chr6:28175283 NA -0.64 -8.97 -0.44 2.26e-17 Parkinson's disease; CRC cis rs9916302 0.904 rs9944411 chr17:37483599 T/C cg03013999 chr17:37608204 MED1 -0.46 -6.98 -0.36 1.62e-11 Glomerular filtration rate (creatinine); CRC cis rs4319547 1.000 rs7295397 chr12:123116209 C/T cg05707623 chr12:122985044 ZCCHC8 -0.75 -9.12 -0.45 7.39e-18 Body mass index; CRC cis rs17127169 0.536 rs74860172 chr1:65497547 T/A cg01340542 chr1:65468273 NA 0.98 6.86 0.35 3.38e-11 Sitting height ratio; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg06090383 chr4:174292579 SAP30 0.47 7.22 0.37 3.53e-12 Liver disease severity in Alagille syndrome; CRC cis rs62244186 0.659 rs9850129 chr3:44532047 C/T cg11003573 chr3:44754125 ZNF502 -0.34 -5.82 -0.31 1.39e-8 Depressive symptoms; CRC cis rs1448094 0.621 rs7133309 chr12:86284078 T/C cg19622623 chr12:86230825 RASSF9 -0.39 -6.23 -0.32 1.42e-9 Major depressive disorder; CRC cis rs911119 0.955 rs17751897 chr20:23592714 T/C cg16589663 chr20:23618590 CST3 0.45 6.3 0.33 9.76e-10 Chronic kidney disease; CRC trans rs2055729 0.710 rs13257396 chr8:9736383 A/C cg08975724 chr8:8085496 FLJ10661 0.5 6.23 0.32 1.46e-9 Multiple myeloma (hyperdiploidy); CRC cis rs172166 0.516 rs1225715 chr6:28113373 C/T cg25164649 chr6:28176230 NA -0.42 -6.14 -0.32 2.31e-9 Cardiac Troponin-T levels; CRC trans rs7267979 0.873 rs6115093 chr20:25210730 C/T cg17903999 chr18:56338584 MALT1 -0.4 -6.34 -0.33 7.56e-10 Liver enzyme levels (alkaline phosphatase); CRC cis rs798554 0.679 rs1636250 chr7:2884433 T/C cg19717773 chr7:2847554 GNA12 -0.43 -5.95 -0.31 6.92e-9 Height; CRC cis rs4689592 0.523 rs3857179 chr4:7070496 T/A cg26116260 chr4:7069785 GRPEL1 0.99 15.03 0.64 3.07e-39 Monocyte percentage of white cells; CRC cis rs13108904 0.901 rs7695691 chr4:1304632 A/G cg19318889 chr4:1322082 MAEA 0.43 6.36 0.33 6.78e-10 Obesity-related traits; CRC cis rs40363 0.716 rs9926612 chr16:3540968 A/C cg22508957 chr16:3507546 NAT15 -0.8 -7.69 -0.39 1.72e-13 Tuberculosis; CRC cis rs11098699 0.821 rs17006775 chr4:124214850 A/G cg09941581 chr4:124220074 SPATA5 -0.43 -6.41 -0.33 4.96e-10 Mosquito bite size; CRC cis rs11764590 0.950 rs11514731 chr7:2051503 C/G cg23378565 chr7:2036160 MAD1L1 -0.47 -6.62 -0.34 1.45e-10 Neuroticism; CRC trans rs7395662 0.611 rs11040073 chr11:48855624 G/A cg21153622 chr11:89784906 NA 0.43 6.9 0.36 2.71e-11 HDL cholesterol; CRC trans rs7615952 0.546 rs2922197 chr3:125322032 G/A cg00769240 chr8:12517080 NA -0.66 -7.32 -0.37 1.96e-12 Blood pressure (smoking interaction); CRC trans rs2303319 0.504 rs35304298 chr2:162617185 G/T cg22902534 chr3:183892754 AP2M1 -0.7 -6.07 -0.32 3.56e-9 Cognitive function; CRC cis rs11148252 0.514 rs1886539 chr13:52726090 C/T cg02158880 chr13:53174818 NA 0.4 5.72 0.3 2.41e-8 Lewy body disease; CRC cis rs6541297 1.000 rs6674744 chr1:230279011 C/T cg05784532 chr1:230284198 GALNT2 0.46 6.27 0.33 1.13e-9 Coronary artery disease; CRC cis rs7584330 0.554 rs76980036 chr2:238426750 G/A cg14458575 chr2:238380390 NA 0.46 6.51 0.34 2.8e-10 Prostate cancer; CRC trans rs2243480 0.831 rs7806717 chr7:65393174 A/G cg10756647 chr7:56101905 PSPH -0.73 -8.07 -0.41 1.36e-14 Diabetic kidney disease; CRC cis rs1322512 1.000 rs1407488 chr6:152945777 G/T cg03415253 chr6:152958462 SYNE1 -0.41 -6.37 -0.33 6.5e-10 Tonometry; CRC trans rs561341 1.000 rs72823787 chr17:30283809 A/T cg20587970 chr11:113659929 NA -1.42 -20.2 -0.74 1.43e-59 Hip circumference adjusted for BMI; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg02785000 chr7:100184615 FBXO24;LRCH4 0.45 6.26 0.33 1.18e-9 Response to antipsychotic treatment; CRC cis rs9515201 0.627 rs9521730 chr13:111031180 C/T cg06243866 chr13:111019493 COL4A2 -0.43 -6.48 -0.34 3.42e-10 White matter hyperintensity burden; CRC cis rs6121246 0.909 rs6060812 chr20:30292803 C/T cg07809909 chr20:30433512 FOXS1 0.35 5.74 0.3 2.18e-8 Mean corpuscular hemoglobin; CRC cis rs9611565 0.512 rs5751147 chr22:42139054 G/A cg06634786 chr22:41940651 POLR3H 0.68 7.61 0.39 3e-13 Vitiligo; CRC cis rs2976388 0.590 rs11785290 chr8:143814849 A/G cg22687807 chr8:143858763 LYNX1 -0.46 -7.68 -0.39 1.82e-13 Urinary tract infection frequency; CRC trans rs79243044 0.786 rs16932549 chr11:5560909 C/T cg21201659 chr10:121652288 SEC23IP -0.44 -6.01 -0.31 4.84e-9 QRS duration in Tripanosoma cruzi seropositivity; CRC cis rs3126085 0.597 rs12047544 chr1:152169922 C/T cg09127314 chr1:152161683 NA 0.49 6.25 0.33 1.26e-9 Atopic dermatitis; CRC trans rs1814175 0.645 rs4411280 chr11:49962750 A/G cg15704280 chr7:45808275 SEPT13 -0.94 -16.88 -0.68 1.75e-46 Height; CRC cis rs2033711 0.870 rs3764534 chr19:58929136 G/A cg00825309 chr19:58991885 ZNF446 -0.46 -6.71 -0.35 8.75e-11 Uric acid clearance; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg17804635 chr8:37554071 ZNF703 0.44 6.64 0.34 1.32e-10 Intelligence (multi-trait analysis); CRC cis rs3092073 0.624 rs11906879 chr20:44591324 C/T cg27529037 chr20:44575021 PCIF1 -0.43 -7.36 -0.38 1.49e-12 Intelligence (multi-trait analysis); CRC cis rs11585357 0.843 rs72633805 chr1:17617471 A/T cg08277548 chr1:17600880 PADI3 -0.89 -11.28 -0.53 3.61e-25 Hair shape; CRC cis rs9807989 0.811 rs11688559 chr2:102969913 C/T cg03938978 chr2:103052716 IL18RAP 0.37 5.97 0.31 6.2e-9 Asthma; CRC cis rs9525927 0.625 rs9533803 chr13:44820608 C/T cg19190762 chr13:44806055 NA 0.56 6.42 0.33 4.87e-10 Dupuytren's disease; CRC trans rs916888 0.610 rs199530 chr17:44836653 C/T cg01341218 chr17:43662625 NA -0.55 -6.97 -0.36 1.7e-11 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC trans rs616147 0.816 rs1768190 chr3:39509440 T/C cg24004139 chr1:26670703 AIM1L -0.37 -5.98 -0.31 5.95e-9 Amyotrophic lateral sclerosis;Amyotrophic lateral sclerosis (sporadic); CRC cis rs9372498 0.536 rs13437605 chr6:118899014 C/T cg15382696 chr6:118971807 C6orf204 0.6 7.7 0.39 1.63e-13 Diastolic blood pressure; CRC cis rs2303759 1.000 rs2303759 chr19:49869051 T/G cg22307029 chr19:49891270 CCDC155 0.68 9.71 0.47 9.37e-20 Multiple sclerosis; CRC trans rs10982213 0.830 rs2274163 chr9:117188714 C/T cg24973289 chr13:45885542 NA 0.41 6.31 0.33 8.76e-10 Interleukin-6 levels; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg05124756 chr4:2263820 MXD4 -0.4 -6.02 -0.31 4.57e-9 Myopia (pathological); CRC cis rs4888262 0.545 rs4243108 chr16:74692453 A/G cg01733217 chr16:74700730 RFWD3 -0.76 -11.71 -0.54 1.02e-26 Testicular germ cell tumor; CRC trans rs3942852 0.774 rs11039519 chr11:48130094 G/C cg03929089 chr4:120376271 NA -0.56 -7.19 -0.37 4.3e-12 Acute lymphoblastic leukemia (childhood); CRC cis rs2066819 0.892 rs75274818 chr12:56627619 A/G cg26714650 chr12:56694279 CS -1.4 -11.28 -0.53 3.63e-25 Psoriasis vulgaris; CRC cis rs912330 0.529 rs4772100 chr13:99196573 G/T cg07423050 chr13:99094983 FARP1 -0.39 -6.06 -0.32 3.74e-9 Alzheimer's disease; CRC cis rs4253772 0.591 rs6007747 chr22:46657261 A/G cg09491104 chr22:46646882 C22orf40 -0.5 -7.66 -0.39 2.05e-13 LDL cholesterol;Cholesterol, total; CRC cis rs9467711 0.606 rs13203358 chr6:26590578 A/T cg12315302 chr6:26189340 HIST1H4D 0.81 6.23 0.32 1.45e-9 Autism spectrum disorder or schizophrenia; CRC cis rs72717009 0.778 rs9427400 chr1:161477204 C/T cg10431340 chr1:161279108 MPZ -0.52 -6.96 -0.36 1.84e-11 Rheumatoid arthritis; CRC cis rs9303401 0.614 rs34058624 chr17:57118121 T/C cg10487724 chr17:56770010 TEX14;RAD51C 0.68 8.27 0.41 3.41e-15 Cognitive test performance; CRC cis rs7274811 0.711 rs291698 chr20:31982250 A/T cg03904042 chr20:32255491 NECAB3;C20orf134 0.43 6.15 0.32 2.25e-9 Height; CRC cis rs7618501 0.521 rs3796386 chr3:49899795 G/A cg24308560 chr3:49941425 MST1R -0.44 -6.76 -0.35 6.43e-11 Intelligence (multi-trait analysis); CRC cis rs116095464 0.681 rs9687745 chr5:229309 C/T cg22857025 chr5:266934 NA -1.21 -16.45 -0.67 8.87e-45 Breast cancer; CRC cis rs367943 1.000 rs348930 chr5:112814763 T/C cg12552261 chr5:112820674 MCC -0.49 -7.66 -0.39 2.06e-13 Type 2 diabetes; CRC cis rs72945132 0.823 rs12292240 chr11:70152612 T/C cg00319359 chr11:70116639 PPFIA1 0.68 7.51 0.38 5.61e-13 Coronary artery disease; CRC cis rs10870270 0.830 rs11146269 chr10:133761820 G/A cg08754478 chr10:133766260 PPP2R2D -0.65 -9.14 -0.45 6.7e-18 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; CRC cis rs4919694 1.000 rs7083328 chr10:104769268 G/A cg04362960 chr10:104952993 NT5C2 1.17 10.93 0.52 6.24e-24 Arsenic metabolism; CRC cis rs1670533 0.932 rs13106586 chr4:1054182 G/A cg27284194 chr4:1044797 NA 0.5 6.2 0.32 1.66e-9 Recombination rate (females); CRC cis rs995000 0.931 rs11208000 chr1:63108374 A/G cg19896129 chr1:63156450 NA 0.4 6.23 0.32 1.46e-9 Triglyceride levels; CRC cis rs2842992 0.747 rs733319 chr6:160221475 A/G cg16489826 chr6:160211363 TCP1;MRPL18 0.5 6.18 0.32 1.91e-9 Age-related macular degeneration (geographic atrophy); CRC cis rs7618501 0.633 rs2252833 chr3:50004209 C/T cg05623727 chr3:50126028 RBM5 0.45 7.54 0.38 4.71e-13 Intelligence (multi-trait analysis); CRC trans rs637571 0.522 rs28578718 chr11:65748400 C/A cg17712092 chr4:129076599 LARP1B 0.7 11.82 0.55 4.26e-27 Eosinophil percentage of white cells; CRC cis rs10788264 0.504 rs7898942 chr10:124024608 G/T cg09507567 chr10:124027408 NA -0.33 -7.11 -0.36 7.23e-12 Total body bone mineral density; CRC cis rs9682041 0.877 rs9682908 chr3:170072010 C/T cg11886554 chr3:170076028 SKIL 0.64 7.69 0.39 1.71e-13 Glomerular filtration rate in non diabetics (creatinine);Glomerular filtration rate (creatinine); CRC cis rs9322193 0.962 rs7745915 chr6:150155247 C/T cg07701084 chr6:150067640 NUP43 0.46 6.36 0.33 6.8e-10 Lung cancer; CRC cis rs1348850 0.567 rs3770012 chr2:178538023 A/G cg22681709 chr2:178499509 PDE11A 0.44 8.21 0.41 5.07e-15 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs7726839 0.507 rs56282020 chr5:596701 T/C cg09021430 chr5:549028 NA -0.72 -8.29 -0.42 2.99e-15 Obesity-related traits; CRC cis rs2404602 0.647 rs36114653 chr15:77025393 G/A cg23625390 chr15:77176239 SCAPER -0.84 -12.79 -0.58 1.15e-30 Blood metabolite levels; CRC cis rs10865541 0.935 rs4971502 chr2:3414029 A/G cg22182287 chr2:3452347 TTC15 0.37 5.81 0.31 1.46e-8 Obesity-related traits; CRC cis rs875971 0.522 rs7784623 chr7:65395034 T/G cg05627663 chr7:65219948 SNORA22;CCT6P1 0.49 7.39 0.38 1.21e-12 Aortic root size; CRC cis rs2836950 0.565 rs2150414 chr21:40614988 A/G cg17971929 chr21:40555470 PSMG1 -0.55 -7.75 -0.39 1.13e-13 Menarche (age at onset); CRC cis rs7647973 0.961 rs10154992 chr3:49276077 C/T cg07690219 chr3:49449608 TCTA;RHOA -0.48 -5.66 -0.3 3.34e-8 Menarche (age at onset); CRC cis rs597539 0.652 rs1249474 chr11:68654774 C/T cg06028808 chr11:68637592 NA 0.41 6.65 0.34 1.2e-10 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs12908161 1.000 rs11632465 chr15:85282045 A/T cg11189052 chr15:85197271 WDR73 0.58 8.45 0.42 9.51e-16 Schizophrenia; CRC cis rs4838594 0.537 rs2377354 chr10:49696844 A/C cg17291251 chr10:49678358 ARHGAP22 -0.42 -6.56 -0.34 2.05e-10 Daytime sleep phenotypes; CRC cis rs2996428 0.561 rs12134919 chr1:3744641 G/A cg13057898 chr1:3703894 LRRC47 0.56 7.59 0.39 3.39e-13 Red cell distribution width; CRC cis rs11031096 0.727 rs12290828 chr11:4144867 C/G cg18678763 chr11:4115507 RRM1 -0.43 -7.37 -0.38 1.42e-12 Mean corpuscular volume;Mean corpuscular hemoglobin; CRC cis rs6860806 0.507 rs2631371 chr5:131703691 G/A cg20512303 chr5:131592959 PDLIM4 -0.39 -6.71 -0.35 8.37e-11 Breast cancer; CRC cis rs896854 0.967 rs896853 chr8:95960855 G/C cg23172400 chr8:95962367 TP53INP1 -0.5 -8.48 -0.42 7.61e-16 Type 2 diabetes; CRC cis rs1008375 1.000 rs10440301 chr4:17663199 G/A cg04450456 chr4:17643702 FAM184B 0.38 5.88 0.31 1e-8 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs10504073 0.584 rs56134839 chr8:49918899 C/T cg00325661 chr8:49890786 NA 0.65 11.69 0.54 1.24e-26 Blood metabolite ratios; CRC cis rs1348850 0.634 rs1534304 chr2:178489264 C/T cg22681709 chr2:178499509 PDE11A -0.37 -6.17 -0.32 2.04e-9 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs1003719 0.688 rs2835660 chr21:38568882 G/C cg10648535 chr21:38446584 PIGP;TTC3 -0.45 -6.23 -0.32 1.45e-9 Eye color traits; CRC trans rs11098499 0.818 rs10008791 chr4:120431469 A/C cg25214090 chr10:38739885 LOC399744 0.63 9.85 0.48 3.24e-20 Corneal astigmatism; CRC cis rs6546550 0.901 rs6721891 chr2:70146121 A/G cg02498382 chr2:70120550 SNRNP27 -0.56 -9.52 -0.46 3.78e-19 Prevalent atrial fibrillation; CRC cis rs34172651 0.517 rs12927710 chr16:24790282 A/C cg00339695 chr16:24857497 SLC5A11 0.36 6.91 0.36 2.45e-11 Intelligence (multi-trait analysis); CRC cis rs5750830 0.649 rs6001588 chr22:39819049 G/C cg24399712 chr22:39784796 NA -0.47 -8.86 -0.44 5.06e-17 Intelligence (multi-trait analysis); CRC cis rs514406 0.708 rs536621 chr1:53309097 A/G cg24675658 chr1:53192096 ZYG11B -0.68 -10.19 -0.49 2.32e-21 Monocyte count; CRC cis rs523522 0.962 rs11065154 chr12:120971417 T/C cg12219531 chr12:120966889 COQ5 0.69 9.25 0.45 2.82e-18 High light scatter reticulocyte count; CRC cis rs8141529 0.748 rs5997412 chr22:29276747 G/A cg15103426 chr22:29168792 CCDC117 0.53 7.43 0.38 9.47e-13 Lymphocyte counts; CRC cis rs9487051 0.676 rs1608044 chr6:109594076 T/C cg01475377 chr6:109611718 NA -0.4 -6.92 -0.36 2.35e-11 Reticulocyte fraction of red cells; CRC cis rs6580649 0.941 rs72644841 chr12:48411987 A/G cg05342945 chr12:48394962 COL2A1 0.42 5.67 0.3 3.09e-8 Lung cancer; CRC cis rs6963495 0.745 rs73192151 chr7:105211876 A/G cg13798780 chr7:105162888 PUS7 0.62 7.14 0.37 6.12e-12 Bipolar disorder (body mass index interaction); CRC cis rs10751667 0.577 rs7946461 chr11:974035 A/G cg06064525 chr11:970664 AP2A2 -0.3 -6.1 -0.32 3.06e-9 Alzheimer's disease (late onset); CRC cis rs853679 0.517 rs34716816 chr6:28046169 C/A cg18032046 chr6:28092343 ZSCAN16 -0.5 -5.89 -0.31 9.74e-9 Depression; CRC cis rs2249694 0.960 rs7075572 chr10:135404358 T/C cg20169779 chr10:135381914 SYCE1 -0.66 -11.29 -0.53 3.21e-25 Obesity-related traits; CRC cis rs1008375 0.898 rs10008445 chr4:17593978 G/T cg16339924 chr4:17578868 LAP3 0.58 7.73 0.39 1.36e-13 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs589448 0.934 rs554591 chr12:69753847 T/C cg14784868 chr12:69753453 YEATS4 0.91 17.62 0.7 2.07e-49 Cerebrospinal fluid biomarker levels; CRC cis rs6952808 0.594 rs3778965 chr7:2138296 G/A cg02951883 chr7:2050386 MAD1L1 -0.67 -10.49 -0.5 2.16e-22 Bipolar disorder and schizophrenia; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg03550506 chr22:32149733 DEPDC5 0.53 7.46 0.38 7.69e-13 Response to antipsychotic treatment; CRC cis rs6502050 0.835 rs7220639 chr17:80146866 G/A cg22110888 chr17:80059540 CCDC57 0.4 6.32 0.33 8.64e-10 Life satisfaction; CRC cis rs7618501 1.000 rs7372725 chr3:49790544 C/A cg24308560 chr3:49941425 MST1R 0.48 7.49 0.38 6.49e-13 Intelligence (multi-trait analysis); CRC cis rs7474896 0.515 rs2505233 chr10:38340265 C/T cg25427524 chr10:38739819 LOC399744 -0.57 -7.01 -0.36 1.33e-11 Obesity (extreme); CRC cis rs6952808 0.595 rs3800917 chr7:2167939 A/G cg21782813 chr7:2030301 MAD1L1 -0.56 -9.67 -0.47 1.23e-19 Bipolar disorder and schizophrenia; CRC cis rs282587 0.569 rs282594 chr13:113379640 A/G cg04656015 chr13:113407548 ATP11A 0.63 7.89 0.4 4.62e-14 Glycated hemoglobin levels; CRC cis rs6502050 0.835 rs7213172 chr17:80085703 G/T cg13198984 chr17:80129470 CCDC57 -0.48 -8.56 -0.43 4.49e-16 Life satisfaction; CRC cis rs8064299 0.597 rs6501737 chr17:72780830 C/T cg25054828 chr17:72772726 NAT9;TMEM104 -0.83 -14.02 -0.61 2.5e-35 Monocyte count; CRC cis rs6952808 0.717 rs10950422 chr7:1926577 T/C cg04267008 chr7:1944627 MAD1L1 -0.58 -8.77 -0.44 9.85e-17 Bipolar disorder and schizophrenia; CRC cis rs9914988 1.000 rs9895443 chr17:27182944 A/G cg16670446 chr17:27188758 MIR451;MIR144 0.59 10.07 0.49 5.63e-21 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs13108904 0.967 rs11727167 chr4:1285521 A/G cg16405210 chr4:1374714 KIAA1530 -0.44 -6.0 -0.31 5.22e-9 Obesity-related traits; CRC cis rs9549367 0.789 rs7999579 chr13:113879357 T/C cg00898013 chr13:113819073 PROZ -0.46 -6.76 -0.35 6.2e-11 Platelet distribution width; CRC cis rs736801 0.808 rs6866614 chr5:131787137 A/G cg07395648 chr5:131743802 NA 0.41 5.97 0.31 6.17e-9 Breast cancer;Mosquito bite size; CRC cis rs916888 0.779 rs199528 chr17:44843136 C/T cg15921436 chr17:44337874 NA 0.81 8.38 0.42 1.55e-15 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs7918232 0.941 rs1755399 chr10:27394958 A/G cg14442939 chr10:27389572 ANKRD26 0.82 8.98 0.44 2.19e-17 Breast cancer; CRC cis rs2985684 0.625 rs4900931 chr14:50022793 A/T cg04989706 chr14:50066350 PPIL5 -0.6 -8.46 -0.42 8.87e-16 Carotid intima media thickness; CRC trans rs6940638 0.956 rs10946899 chr6:27023694 T/A cg06606381 chr12:133084897 FBRSL1 -0.55 -6.22 -0.32 1.54e-9 Intelligence (multi-trait analysis); CRC cis rs10256972 0.591 rs10229680 chr7:1158565 C/T cg03188948 chr7:1209495 NA 0.47 6.58 0.34 1.81e-10 Longevity;Endometriosis; CRC trans rs951252 0.504 rs11734405 chr4:146081096 C/T cg23668004 chr7:4784903 FOXK1 0.46 6.18 0.32 1.86e-9 Hip circumference; CRC cis rs2276314 0.857 rs28431958 chr18:33578401 T/G cg05985134 chr18:33552581 C18orf21 0.49 6.39 0.33 5.68e-10 Endometriosis;Drug-induced torsades de pointes; CRC cis rs7586879 0.964 rs6545795 chr2:25116783 C/T cg22495460 chr2:25135724 ADCY3 -0.73 -11.97 -0.55 1.2100000000000001e-27 Body mass index; CRC cis rs6681460 0.934 rs4655628 chr1:67052609 T/C cg02459107 chr1:67143332 SGIP1 0.48 8.17 0.41 6.69e-15 Presence of antiphospholipid antibodies; CRC cis rs6543140 0.927 rs917999 chr2:103067869 G/A cg03938978 chr2:103052716 IL18RAP 0.42 6.7 0.35 8.81e-11 Blood protein levels; CRC cis rs629535 0.735 rs525610 chr8:70074535 A/G cg26132723 chr8:70041827 NA 0.35 5.71 0.3 2.51e-8 Dupuytren's disease; CRC cis rs4920343 0.671 rs1010113 chr1:19071752 T/C cg19637330 chr1:19110922 NA 0.41 6.13 0.32 2.56e-9 Knee osteoarthritis; CRC cis rs763121 0.853 rs5757200 chr22:39043491 T/G cg06022373 chr22:39101656 GTPBP1 0.78 12.39 0.56 3.54e-29 Menopause (age at onset); CRC cis rs11122272 0.701 rs1009227 chr1:231480507 A/G cg06096015 chr1:231504339 EGLN1 0.38 5.61 0.3 4.23e-8 Hemoglobin concentration; CRC cis rs9487051 0.676 rs2884013 chr6:109599952 C/T cg21918786 chr6:109611834 NA -0.4 -7.13 -0.37 6.28e-12 Reticulocyte fraction of red cells; CRC cis rs11602339 1 rs11602339 chr11:47761471 C/T cg18512352 chr11:47633146 NA -0.5 -9.54 -0.47 3.37e-19 Body mass index; CRC cis rs13191362 0.935 rs66962088 chr6:162963891 C/T cg21926612 chr6:163149169 PACRG;PARK2 0.82 10.41 0.5 3.86e-22 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs7258465 0.931 rs34053595 chr19:18556749 T/C cg10790698 chr19:18539756 SSBP4 -0.43 -7.96 -0.4 2.77e-14 Breast cancer; CRC cis rs9914988 0.943 rs4795465 chr17:27151498 A/G cg20469991 chr17:27169893 C17orf63 0.6 7.23 0.37 3.38e-12 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs1552244 0.935 rs7618815 chr3:10151045 A/G cg13047869 chr3:10149882 C3orf24 0.57 7.73 0.39 1.34e-13 Alzheimer's disease; CRC cis rs2976388 0.578 rs3736010 chr8:143817503 T/C cg24634471 chr8:143751801 JRK -0.51 -6.88 -0.35 3.09e-11 Urinary tract infection frequency; CRC cis rs7119 0.717 rs12916642 chr15:77818426 G/T cg10437265 chr15:77819839 NA 0.69 12.74 0.57 1.76e-30 Type 2 diabetes; CRC cis rs1707322 0.721 rs11211149 chr1:46112218 T/C cg03146154 chr1:46216737 IPP 0.66 9.55 0.47 3.06e-19 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs8077889 1.000 rs17675122 chr17:41886190 A/G cg16892393 chr17:41919603 NA 0.56 7.96 0.4 2.87e-14 Triglycerides; CRC cis rs2749592 0.550 rs7917262 chr10:37874602 A/C cg00409905 chr10:38381863 ZNF37A 0.58 9.35 0.46 1.41e-18 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs2992756 0.625 rs2992752 chr1:18808526 A/C cg14356550 chr1:18808102 KLHDC7A -0.39 -5.78 -0.3 1.76e-8 Breast cancer; CRC cis rs10493773 0.928 rs12741600 chr1:86191172 A/C cg17807903 chr1:86174739 ZNHIT6 -0.52 -10.5 -0.5 1.96e-22 Urate levels in overweight individuals; CRC cis rs9733 0.519 rs7521898 chr1:150707596 G/A cg10589385 chr1:150898437 SETDB1 0.29 6.13 0.32 2.47e-9 Tonsillectomy; CRC cis rs932541 1.000 rs6043988 chr20:16455165 C/T cg17003395 chr20:16555519 KIF16B 0.41 5.73 0.3 2.25e-8 Intelligence; CRC cis rs10504229 0.728 rs17804666 chr8:58154473 C/T cg24829409 chr8:58192753 C8orf71 -0.58 -7.96 -0.4 2.86e-14 Developmental language disorder (linguistic errors); CRC cis rs4237845 0.611 rs4534624 chr12:58332427 A/G cg02175503 chr12:58329896 NA 0.79 12.42 0.56 2.73e-29 Intelligence (multi-trait analysis); CRC cis rs4563143 0.675 rs112383987 chr19:29261081 C/T cg12667521 chr19:29218732 NA 0.49 7.49 0.38 6.26e-13 Methadone dose in opioid dependence; CRC cis rs6582630 0.502 rs1607876 chr12:38355750 T/C cg26384229 chr12:38710491 ALG10B 0.68 9.69 0.47 1.09e-19 Drug-induced liver injury (flucloxacillin); CRC cis rs10540 1.000 rs35255804 chr11:492617 G/A cg03576123 chr11:487126 PTDSS2 -1.04 -10.79 -0.51 1.91e-23 Body mass index; CRC cis rs2727020 0.521 rs7131163 chr11:49574774 C/T cg25886479 chr11:50257625 LOC441601 -0.34 -5.7 -0.3 2.7e-8 Coronary artery disease; CRC cis rs1448094 0.512 rs6539931 chr12:86247473 C/T cg18827107 chr12:86230957 RASSF9 -0.45 -7.49 -0.38 6.6e-13 Major depressive disorder; CRC cis rs7715806 0.500 rs17649332 chr5:75003878 T/C cg19683494 chr5:74908142 NA 0.51 5.71 0.3 2.51e-8 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs1003719 0.788 rs2835584 chr21:38460338 A/T cg10648535 chr21:38446584 PIGP;TTC3 0.52 7.4 0.38 1.11e-12 Eye color traits; CRC cis rs977987 0.806 rs11862582 chr16:75431295 T/C cg03315344 chr16:75512273 CHST6 0.54 9.0 0.44 1.89e-17 Dupuytren's disease; CRC cis rs2836974 0.899 rs34433511 chr21:40618883 A/C cg11644478 chr21:40555479 PSMG1 0.81 12.25 0.56 1.12e-28 Cognitive function; CRC cis rs12824058 0.831 rs4759653 chr12:130812604 T/C cg26677194 chr12:130822605 PIWIL1 0.45 7.18 0.37 4.53e-12 Menopause (age at onset); CRC cis rs875971 0.862 rs13536 chr7:66019190 G/A cg18252515 chr7:66147081 NA 0.43 6.21 0.32 1.61e-9 Aortic root size; CRC cis rs929354 1.000 rs1182410 chr7:157063837 C/T cg05182265 chr7:156933206 UBE3C 0.73 13.63 0.6 7.84e-34 Body mass index; CRC cis rs9292777 0.720 rs4957291 chr5:40431949 G/A cg09067459 chr5:40385259 NA -0.53 -8.58 -0.43 3.87e-16 Crohn's disease;Multiple sclerosis; CRC cis rs155076 0.711 rs9550724 chr13:21885030 G/T cg23743428 chr13:21893420 NA -0.38 -5.76 -0.3 1.97e-8 White matter hyperintensity burden; CRC trans rs6951245 0.872 rs75493422 chr7:1072890 C/T cg13565492 chr6:43139072 SRF -0.71 -7.2 -0.37 4.03e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs796364 0.774 rs112564437 chr2:201074048 G/C cg25936922 chr2:200820526 C2orf60;C2orf47 -0.49 -5.63 -0.3 3.78e-8 Schizophrenia; CRC cis rs4665809 0.878 rs4143538 chr2:26290178 A/C cg25036284 chr2:26402008 FAM59B -0.47 -5.84 -0.31 1.24e-8 Gut microbiome composition (summer); CRC cis rs11971779 0.680 rs3924445 chr7:139044172 C/A cg23387468 chr7:139079360 LUC7L2 0.41 7.04 0.36 1.14e-11 Diisocyanate-induced asthma; CRC cis rs1799949 1.000 rs8070085 chr17:41341984 C/T cg05368731 chr17:41323189 NBR1 -0.69 -10.56 -0.5 1.2e-22 Menopause (age at onset); CRC cis rs9443645 0.901 rs2050663 chr6:79753394 T/C cg09184832 chr6:79620586 NA -0.49 -8.75 -0.43 1.17e-16 Intelligence (multi-trait analysis); CRC cis rs2624839 0.704 rs13064381 chr3:50233317 C/T cg05623727 chr3:50126028 RBM5 0.4 5.9 0.31 9.09e-9 Intelligence (multi-trait analysis); CRC cis rs17065868 0.764 rs9533857 chr13:45029951 A/G cg10246903 chr13:45222710 NA 0.54 5.69 0.3 2.79e-8 Antineutrophil cytoplasmic antibody-associated vasculitis; CRC trans rs951252 0.504 rs11734405 chr4:146081096 C/T cg13884470 chr9:86595151 HNRNPK;RMI1 0.43 6.11 0.32 2.82e-9 Hip circumference; CRC cis rs7119 0.667 rs4886889 chr15:77902347 T/C cg10437265 chr15:77819839 NA -0.5 -8.93 -0.44 2.99e-17 Type 2 diabetes; CRC cis rs1552244 0.882 rs7633769 chr3:10020622 C/T cg00166722 chr3:10149974 C3orf24 0.57 7.76 0.39 1.1e-13 Alzheimer's disease; CRC cis rs738322 0.555 rs5750548 chr22:38547016 C/A cg25457927 chr22:38595422 NA -0.39 -7.92 -0.4 3.65e-14 Cutaneous nevi; CRC trans rs4378999 0.660 rs7639301 chr3:50837991 C/G cg12383621 chr7:7735611 RPA3 -0.48 -6.1 -0.32 2.95e-9 Waist circumference adjusted for BMI in non-smokers;Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction); CRC cis rs6942756 0.747 rs598412 chr7:129127736 C/T cg02491457 chr7:128862824 NA 0.58 7.94 0.4 3.31e-14 White matter hyperintensity burden; CRC cis rs1401999 0.714 rs1000002 chr3:183635768 A/G cg01324343 chr3:183735012 ABCC5 -0.56 -8.86 -0.44 5.22e-17 Anterior chamber depth; CRC cis rs57221529 0.766 rs12518859 chr5:587432 C/T cg09021430 chr5:549028 NA -0.72 -7.9 -0.4 4.17e-14 Lung disease severity in cystic fibrosis; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg20134190 chr8:99129593 POP1;HRSP12 0.47 6.94 0.36 2.04e-11 Response to antipsychotic treatment; CRC cis rs7098414 0.511 rs10466236 chr10:82149717 C/T cg00277334 chr10:82204260 NA 0.44 7.2 0.37 4.2e-12 Post bronchodilator FEV1; CRC cis rs7666738 0.830 rs13141752 chr4:98893128 G/A cg05340658 chr4:99064831 C4orf37 0.56 8.42 0.42 1.16e-15 Colonoscopy-negative controls vs population controls; CRC trans rs10506458 0.834 rs55966529 chr12:63384114 A/C cg22491629 chr6:157744540 C6orf35 -0.74 -8.33 -0.42 2.15e-15 Hemostatic factors and hematological phenotypes; CRC cis rs2836974 0.899 rs34978594 chr21:40580003 C/T cg11890956 chr21:40555474 PSMG1 1.09 18.58 0.72 3.25e-53 Cognitive function; CRC cis rs13191362 1.000 rs34594856 chr6:163051845 C/T cg23758597 chr6:163146217 PARK2 -0.66 -6.55 -0.34 2.24e-10 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs6693567 0.545 rs35705743 chr1:150451832 G/A cg15654264 chr1:150340011 RPRD2 0.41 6.19 0.32 1.84e-9 Migraine; CRC cis rs7932354 0.528 rs747650 chr11:47176005 C/T cg19486271 chr11:47235900 DDB2 0.45 6.71 0.35 8.36e-11 Bone mineral density (hip);Bone mineral density; CRC cis rs9522267 0.535 rs4773393 chr13:112229755 A/G cg14352298 chr13:112236639 NA 0.3 6.87 0.35 3.17e-11 Hepatitis; CRC cis rs1577917 1.000 rs1962716 chr6:86648436 C/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.5 -6.2 -0.32 1.65e-9 Response to antipsychotic treatment; CRC cis rs62244186 0.520 rs2372828 chr3:44784949 A/G cg10263370 chr3:44754102 ZNF502 0.37 6.31 0.33 9.25e-10 Depressive symptoms; CRC cis rs7973719 0.833 rs7970916 chr12:7357746 T/C cg07052231 chr12:7363540 PEX5 0.52 8.4 0.42 1.39e-15 IgG glycosylation; CRC trans rs7615952 0.599 rs12496921 chr3:125701948 C/G cg07211511 chr3:129823064 LOC729375 -0.79 -10.9 -0.52 7.88e-24 Blood pressure (smoking interaction); CRC cis rs477895 0.838 rs12794145 chr11:64006484 C/T cg23719950 chr11:63933701 MACROD1 -0.58 -6.89 -0.36 2.87e-11 Mean platelet volume; CRC cis rs13191362 0.935 rs35446205 chr6:162938769 C/G cg21926612 chr6:163149169 PACRG;PARK2 0.79 9.56 0.47 2.82e-19 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs6665290 0.904 rs2297418 chr1:227192579 A/C cg10327440 chr1:227177885 CDC42BPA -1.04 -22.97 -0.78 2.42e-70 Myeloid white cell count; CRC cis rs7659604 0.643 rs6838881 chr4:122663616 A/T cg19748678 chr4:122722346 EXOSC9 0.46 6.55 0.34 2.16e-10 Type 2 diabetes; CRC cis rs11148252 1.000 rs11148252 chr13:53009048 C/T cg02158880 chr13:53174818 NA 0.43 6.46 0.34 3.8e-10 Lewy body disease; CRC cis rs1448094 0.511 rs61930587 chr12:86158793 T/C cg00310523 chr12:86230176 RASSF9 0.42 6.71 0.35 8.28e-11 Major depressive disorder; CRC cis rs6964587 0.935 rs9770444 chr7:91783162 T/G cg17063962 chr7:91808500 NA 0.85 15.11 0.64 1.46e-39 Breast cancer; CRC cis rs9322193 0.962 rs10872656 chr6:150120580 A/C cg07701084 chr6:150067640 NUP43 0.48 6.77 0.35 6.07e-11 Lung cancer; CRC trans rs16846053 0.786 rs62187567 chr2:162363066 G/A cg18122310 chr12:50236657 BCDIN3D -0.72 -6.07 -0.32 3.54e-9 Blood osmolality (transformed sodium); CRC cis rs644799 0.932 rs480079 chr11:95643777 A/T cg25478527 chr11:95522999 CEP57;FAM76B -0.47 -7.05 -0.36 1.07e-11 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs853679 0.517 rs9295758 chr6:28120663 C/G cg21251018 chr6:28226885 NKAPL 0.48 6.17 0.32 2.02e-9 Depression; CRC cis rs736801 0.836 rs2522052 chr5:131798487 C/T cg21138405 chr5:131827807 IRF1 0.36 6.15 0.32 2.21e-9 Breast cancer;Mosquito bite size; CRC cis rs6700896 0.931 rs1892534 chr1:66105944 C/T cg04111102 chr1:66153794 NA 0.32 5.72 0.3 2.33e-8 C-reactive protein;Mean corpuscular volume;Mean corpuscular hemoglobin; CRC cis rs10504229 0.683 rs34859456 chr8:58117722 A/C cg02725872 chr8:58115012 NA -0.64 -11.55 -0.54 3.85e-26 Developmental language disorder (linguistic errors); CRC cis rs1728785 0.901 rs11642189 chr16:68583990 G/A cg02972257 chr16:68554789 NA -0.58 -7.24 -0.37 3.21e-12 Ulcerative colitis; CRC cis rs1223397 0.938 rs13205692 chr6:13291560 C/T cg00460589 chr6:13274354 PHACTR1 0.5 6.0 0.31 5.11e-9 Blood pressure; CRC cis rs17767392 0.874 rs34649709 chr14:71762296 G/T cg13720639 chr14:72061746 SIPA1L1 -0.53 -6.86 -0.35 3.45e-11 Mitral valve prolapse; CRC cis rs367943 1.000 rs348931 chr5:112812864 G/C cg12552261 chr5:112820674 MCC -0.49 -7.66 -0.39 2.06e-13 Type 2 diabetes; CRC trans rs3942852 0.806 rs1875696 chr11:48133526 G/A cg03929089 chr4:120376271 NA -0.56 -7.13 -0.37 6.44e-12 Acute lymphoblastic leukemia (childhood); CRC cis rs11098499 0.954 rs12506546 chr4:120301618 T/C cg24375607 chr4:120327624 NA 0.5 7.81 0.4 7.88e-14 Corneal astigmatism; CRC cis rs3760982 1.000 rs10421887 chr19:44294849 C/T cg12072164 chr19:44306565 LYPD5 -0.41 -6.44 -0.33 4.13e-10 Breast cancer (estrogen-receptor negative);Breast cancer; CRC cis rs875971 0.767 rs12668005 chr7:65909021 T/C cg18252515 chr7:66147081 NA -0.41 -5.75 -0.3 2.01e-8 Aortic root size; CRC cis rs1997103 1.000 rs2331063 chr7:55408914 A/G cg17469321 chr7:55412551 NA 0.72 11.28 0.53 3.48e-25 QRS interval (sulfonylurea treatment interaction); CRC cis rs7772486 0.622 rs1292333 chr6:145982344 C/T cg23711669 chr6:146136114 FBXO30 -0.65 -10.69 -0.51 4.17e-23 Lobe attachment (rater-scored or self-reported); CRC cis rs826838 0.616 rs2387921 chr12:38624767 T/C cg13010199 chr12:38710504 ALG10B -0.42 -6.03 -0.32 4.33e-9 Heart rate; CRC cis rs68170813 0.559 rs2107319 chr7:106863744 T/C cg02696742 chr7:106810147 HBP1 -0.56 -6.48 -0.34 3.27e-10 Coronary artery disease; CRC cis rs908922 0.676 rs477621 chr1:152486252 T/C cg23254163 chr1:152506842 NA 0.45 8.84 0.44 5.7e-17 Hair morphology; CRC cis rs6840360 0.598 rs11944921 chr4:152731109 A/G cg09659197 chr4:152720779 NA -0.38 -8.17 -0.41 6.75e-15 Intelligence (multi-trait analysis); CRC cis rs2463822 1.000 rs2513074 chr11:62100880 A/C cg06239285 chr11:62104954 ASRGL1 0.97 11.38 0.53 1.58e-25 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs6933660 0.745 rs3800272 chr6:151744283 A/G cg10883421 chr6:151773342 RMND1;C6orf211 -0.72 -12.46 -0.57 1.93e-29 Menarche (age at onset); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg06905471 chr2:29092871 TRMT61B 0.46 6.69 0.35 9.64e-11 Intelligence (multi-trait analysis); CRC cis rs889312 0.521 rs12651942 chr5:56088484 C/T cg24531977 chr5:56204891 C5orf35 -0.48 -7.35 -0.38 1.63e-12 Breast cancer;Breast cancer (early onset); CRC cis rs9368481 0.672 rs3931463 chr6:26939797 G/A cg12292205 chr6:26970375 C6orf41 0.66 10.66 0.51 5.65e-23 Autism spectrum disorder or schizophrenia; CRC cis rs875971 1.000 rs697970 chr7:65560052 G/C cg18252515 chr7:66147081 NA 0.38 5.65 0.3 3.52e-8 Aortic root size; CRC cis rs2153535 0.580 rs1034272 chr6:8469335 G/C cg21535247 chr6:8435926 SLC35B3 0.5 7.63 0.39 2.48e-13 Motion sickness; CRC cis rs11229555 0.645 rs10466659 chr11:58190112 A/G cg15696309 chr11:58395628 NA -0.82 -10.31 -0.49 8.59e-22 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; CRC cis rs853679 0.607 rs201002 chr6:27808192 A/G cg23259851 chr6:27775964 HIST1H2AI;HIST1H2BL 0.66 5.67 0.3 3.13e-8 Depression; CRC cis rs58688157 0.705 rs7928902 chr11:609068 G/A cg09218773 chr11:619014 MUPCDH -0.43 -6.19 -0.32 1.78e-9 Systemic lupus erythematosus; CRC cis rs9287719 0.839 rs7600695 chr2:10739945 A/G cg00105475 chr2:10696890 NA 0.45 7.3 0.37 2.19e-12 Prostate cancer; CRC cis rs344364 0.511 rs62040571 chr16:1948514 C/G cg03013636 chr16:1946785 NA 0.58 7.08 0.36 8.69e-12 Glomerular filtration rate in chronic kidney disease; CRC cis rs68170813 0.559 rs17428126 chr7:106897037 C/T cg02696742 chr7:106810147 HBP1 -0.6 -6.65 -0.34 1.25e-10 Coronary artery disease; CRC cis rs9309473 0.554 rs4330127 chr2:73581320 A/T cg20560298 chr2:73613845 ALMS1 -0.48 -6.54 -0.34 2.4e-10 Metabolite levels; CRC cis rs10791097 0.694 rs7106973 chr11:130758113 G/A cg12179176 chr11:130786555 SNX19 0.75 12.38 0.56 3.8e-29 Autism spectrum disorder or schizophrenia;Schizophrenia; CRC cis rs6938 0.534 rs4886636 chr15:75196176 G/A cg14664628 chr15:75095509 CSK -0.67 -10.91 -0.52 7.3e-24 Breast cancer; CRC cis rs79349575 0.756 rs3848460 chr17:47047114 A/G cg00947319 chr17:47005597 UBE2Z 0.34 5.72 0.3 2.38e-8 Type 2 diabetes; CRC trans rs7939886 0.920 rs17150038 chr11:55863414 A/T cg03929089 chr4:120376271 NA 0.66 5.96 0.31 6.44e-9 Myopia (pathological); CRC cis rs916888 0.821 rs199514 chr17:44856881 G/A cg15921436 chr17:44337874 NA -0.69 -7.75 -0.39 1.17e-13 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs826838 0.967 rs11169169 chr12:39093153 A/C cg13010199 chr12:38710504 ALG10B 0.45 5.89 0.31 9.73e-9 Heart rate; CRC trans rs11098499 0.754 rs878372 chr4:120238780 A/C cg25214090 chr10:38739885 LOC399744 0.53 8.45 0.42 9.68e-16 Corneal astigmatism; CRC cis rs10504229 0.724 rs58715581 chr8:58134568 A/G cg05313129 chr8:58192883 C8orf71 -0.43 -6.11 -0.32 2.74e-9 Developmental language disorder (linguistic errors); CRC cis rs2398893 0.960 rs56335449 chr9:96748795 G/A cg14459158 chr9:96720562 NA 0.48 7.3 0.37 2.19e-12 Waist-hip ratio;Waist-to-hip ratio adjusted for body mass index; CRC cis rs28386778 0.897 rs7207005 chr17:61860355 A/G cg06601766 chr17:61851465 DDX42;CCDC47 0.46 6.22 0.32 1.51e-9 Prudent dietary pattern; CRC cis rs6500395 1.000 rs1558815 chr16:48704869 C/A cg04672837 chr16:48644449 N4BP1 -0.45 -6.63 -0.34 1.38e-10 Response to tocilizumab in rheumatoid arthritis; CRC cis rs35306767 0.903 rs12250937 chr10:900209 C/T cg26597838 chr10:835615 NA 0.88 11.03 0.52 2.73e-24 Eosinophil percentage of granulocytes; CRC cis rs9287719 0.967 rs13034061 chr2:10739651 C/T cg00105475 chr2:10696890 NA 0.45 7.3 0.37 2.19e-12 Prostate cancer; CRC cis rs2762353 0.538 rs35670731 chr6:25728235 C/T cg15691649 chr6:25882328 NA 0.49 6.41 0.33 5.05e-10 Blood metabolite levels; CRC cis rs853679 0.517 rs4713146 chr6:28111536 A/T cg12963246 chr6:28129442 ZNF389 0.49 5.7 0.3 2.71e-8 Depression; CRC cis rs909002 0.830 rs10914460 chr1:32113216 T/C cg01639898 chr1:32083012 HCRTR1 0.31 6.49 0.34 3.22e-10 Intelligence (multi-trait analysis); CRC cis rs6951245 0.872 rs77434655 chr7:1098405 G/A cg04025307 chr7:1156635 C7orf50 0.64 6.81 0.35 4.53e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC trans rs11039798 0.582 rs60764175 chr11:48775856 T/G cg15704280 chr7:45808275 SEPT13 0.67 7.03 0.36 1.17e-11 Axial length; CRC cis rs11105298 0.891 rs3825330 chr12:89933710 C/T cg00757033 chr12:89920650 WDR51B 0.39 6.28 0.33 1.05e-9 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; CRC cis rs1008375 1.000 rs6818639 chr4:17633049 A/G cg02297831 chr4:17616191 MED28 0.43 5.76 0.3 1.98e-8 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs2243480 1.000 rs1618893 chr7:66096119 C/T cg18252515 chr7:66147081 NA -1.01 -10.66 -0.51 5.63e-23 Diabetic kidney disease; CRC cis rs7119 0.700 rs7497168 chr15:77886231 A/C cg10437265 chr15:77819839 NA -0.44 -7.56 -0.38 3.95e-13 Type 2 diabetes; CRC cis rs9788721 0.836 rs72738736 chr15:78765122 G/T cg18825076 chr15:78729989 IREB2 -0.43 -6.58 -0.34 1.84e-10 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio;Emphysema imaging phenotypes;Emphysema distribution in smoking;Local histogram emphysema pattern;Post bronchodilator FEV1/FVC ratio in COPD; CRC cis rs1799949 1.000 rs12944458 chr17:41180772 C/T cg25072359 chr17:41440525 NA 0.47 6.92 0.36 2.32e-11 Menopause (age at onset); CRC cis rs6694270 0.913 rs11261069 chr1:19117300 C/G cg26220594 chr1:19110978 NA -0.46 -6.73 -0.35 7.62e-11 Drug-induced liver injury (nitrofurantoin); CRC cis rs9467773 0.620 rs9295701 chr6:26627508 T/C cg09904177 chr6:26538194 HMGN4 0.72 11.32 0.53 2.52e-25 Intelligence (multi-trait analysis); CRC cis rs950776 0.616 rs647041 chr15:78880481 T/C cg06917634 chr15:78832804 PSMA4 -0.56 -8.62 -0.43 2.89e-16 Sudden cardiac arrest; CRC cis rs2243480 0.803 rs36004293 chr7:65416512 T/C cg18252515 chr7:66147081 NA -1.07 -12.49 -0.57 1.49e-29 Diabetic kidney disease; CRC cis rs1728785 1.000 rs1645936 chr16:68563743 A/G cg02972257 chr16:68554789 NA -0.51 -6.25 -0.33 1.25e-9 Ulcerative colitis; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg07840538 chr7:99097998 ZNF394 0.43 6.09 0.32 3.17e-9 Response to antipsychotic treatment; CRC cis rs412050 0.502 rs17759796 chr22:22190163 A/C cg16974014 chr22:22007515 MIR130B -0.43 -6.0 -0.31 5.29e-9 Attention deficit hyperactivity disorder; CRC cis rs644799 1.000 rs544119 chr11:95538624 G/A cg03916912 chr11:95522834 CEP57;FAM76B 0.95 18.15 0.71 1.71e-51 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs6738485 0.763 rs11681976 chr2:106841591 C/A cg15412446 chr2:106886593 NA -0.4 -6.51 -0.34 2.89e-10 Pursuit maintenance gain;Pursuit maintenance gain in psychotic disorders; CRC cis rs514406 0.708 rs480299 chr1:53320274 G/T cg08859206 chr1:53392774 SCP2 -0.59 -9.39 -0.46 9.93e-19 Monocyte count; CRC cis rs11098499 0.754 rs10006259 chr4:120242145 C/T cg24375607 chr4:120327624 NA 0.48 7.61 0.39 2.87e-13 Corneal astigmatism; CRC cis rs561341 0.883 rs886224 chr17:30229902 T/C cg12193833 chr17:30244370 NA -0.68 -8.2 -0.41 5.56e-15 Hip circumference adjusted for BMI; CRC cis rs1799949 1.000 rs2070834 chr17:41242285 T/G cg05368731 chr17:41323189 NBR1 0.68 10.01 0.48 8.88e-21 Menopause (age at onset); CRC cis rs9457247 1.000 rs422694 chr6:167406074 G/T cg23791538 chr6:167370224 RNASET2 -0.38 -5.94 -0.31 7.32e-9 Crohn's disease; CRC cis rs9649465 1.000 rs11765478 chr7:123362872 A/C cg03229431 chr7:123269106 ASB15 -0.36 -5.61 -0.3 4.22e-8 Migraine; CRC cis rs9611565 0.512 rs5996063 chr22:42168767 G/A cg17554472 chr22:41940697 POLR3H 0.56 5.65 0.3 3.4e-8 Vitiligo; CRC cis rs798554 0.757 rs960273 chr7:2857876 T/C cg14895029 chr7:2775587 GNA12 -0.45 -6.46 -0.34 3.87e-10 Height; CRC cis rs9517313 0.584 rs9556974 chr13:99216302 G/C cg07423050 chr13:99094983 FARP1 -0.55 -7.85 -0.4 5.84e-14 Neuroticism; CRC cis rs10504229 0.593 rs75047131 chr8:58001320 A/G cg11062466 chr8:58055876 NA 0.51 6.34 0.33 7.47e-10 Developmental language disorder (linguistic errors); CRC cis rs7666738 0.800 rs2865988 chr4:99067807 T/C cg05340658 chr4:99064831 C4orf37 0.6 9.33 0.46 1.57e-18 Colonoscopy-negative controls vs population controls; CRC cis rs4722166 0.630 rs13311199 chr7:22789793 A/C cg05472934 chr7:22766657 IL6 0.77 12.59 0.57 5.91e-30 Lung cancer; CRC cis rs6582630 0.638 rs4882309 chr12:38448595 A/G cg13010199 chr12:38710504 ALG10B -0.41 -5.73 -0.3 2.33e-8 Drug-induced liver injury (flucloxacillin); CRC cis rs9322193 0.810 rs62439811 chr6:149961552 C/T cg07701084 chr6:150067640 NUP43 0.56 7.88 0.4 4.83e-14 Lung cancer; CRC cis rs6547741 1.000 rs7604798 chr2:27824940 T/C cg27432699 chr2:27873401 GPN1 0.77 13.64 0.6 7.11e-34 Oral cavity cancer; CRC cis rs909002 0.849 rs2280386 chr1:32086912 A/C cg13919466 chr1:32135498 COL16A1 -0.32 -6.14 -0.32 2.42e-9 Intelligence (multi-trait analysis); CRC trans rs3749237 0.964 rs34522271 chr3:49808517 A/G cg21659725 chr3:3221576 CRBN 0.56 7.88 0.4 4.96e-14 Resting heart rate; CRC cis rs6429082 0.585 rs7524848 chr1:235711688 G/C cg26050004 chr1:235667680 B3GALNT2 -0.46 -5.76 -0.3 1.9e-8 Adiposity; CRC cis rs10504229 0.906 rs6990615 chr8:58182956 G/A cg05313129 chr8:58192883 C8orf71 -0.47 -6.99 -0.36 1.49e-11 Developmental language disorder (linguistic errors); CRC cis rs2657888 0.628 rs2638285 chr12:56886361 A/G cg23002907 chr12:56915593 RBMS2 0.39 6.09 0.32 3.18e-9 Adiponectin levels; CRC cis rs9911578 0.935 rs9893351 chr17:57023326 G/A cg12560992 chr17:57184187 TRIM37 0.83 14.72 0.63 4.92e-38 Intelligence (multi-trait analysis); CRC cis rs4843747 0.671 rs9933794 chr16:88116981 T/C cg03395651 chr16:88107091 BANP 0.54 7.27 0.37 2.56e-12 Menopause (age at onset); CRC cis rs9916302 0.706 rs12937013 chr17:37665571 G/A cg15445000 chr17:37608096 MED1 0.36 6.28 0.33 1.08e-9 Glomerular filtration rate (creatinine); CRC cis rs78456975 0.546 rs72776254 chr2:1527881 C/T cg26248373 chr2:1572462 NA -0.62 -6.51 -0.34 2.74e-10 Placebo response in major depressive disorder (% change in symptom score); CRC cis rs769267 0.859 rs2916076 chr19:19545990 T/C cg01262667 chr19:19385393 TM6SF2 0.36 5.9 0.31 9.24e-9 Tonsillectomy; CRC cis rs644799 1.000 rs543530 chr11:95545170 A/G cg25622487 chr11:95524042 FAM76B;CEP57 0.76 11.87 0.55 2.62e-27 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs2996428 0.667 rs2368534 chr1:3740640 C/T cg13057898 chr1:3703894 LRRC47 0.5 6.58 0.34 1.87e-10 Red cell distribution width; CRC cis rs736801 0.808 rs2248116 chr5:131804347 C/A cg00255919 chr5:131827918 IRF1 0.34 5.74 0.3 2.17e-8 Breast cancer;Mosquito bite size; CRC cis rs1429411 1.000 rs1429411 chr2:198144002 A/G cg10820045 chr2:198174542 NA -0.38 -6.25 -0.33 1.28e-9 Interferon alpha levels in systemic lupus erythematosus; CRC cis rs28386778 1.000 rs28386778 chr17:61964815 T/C cg11494091 chr17:61959527 GH2 0.62 9.99 0.48 1.03e-20 Prudent dietary pattern; CRC cis rs2213920 0.516 rs71505548 chr9:118169753 G/A cg13918206 chr9:118159781 DEC1 -0.81 -7.64 -0.39 2.38e-13 Docetaxel-induced peripheral neuropathy in metastatic castrate-resistant prostate cancer; CRC cis rs2857891 1.000 rs2595500 chr11:6963165 C/T cg26870460 chr11:6947759 ZNF215 -0.54 -6.05 -0.32 3.9e-9 Response to cytadine analogues (cytosine arabinoside); CRC cis rs9430161 0.579 rs7542354 chr1:11040385 G/A cg27631724 chr1:11040367 C1orf127 0.36 7.3 0.37 2.15e-12 Ewing sarcoma; CRC cis rs2932538 0.846 rs7546203 chr1:113154529 C/A cg22162597 chr1:113214053 CAPZA1 0.72 10.31 0.49 8.65e-22 Systolic blood pressure;Diastolic blood pressure;Hypertension;Blood pressure; CRC cis rs11212617 0.967 rs227054 chr11:108257943 A/G cg12106634 chr11:108092400 ATM;NPAT 0.41 5.96 0.31 6.59e-9 Response to metformin in type 2 diabetes (glycemic); CRC cis rs6912958 1.000 rs6912958 chr6:88133315 G/A cg08069147 chr6:88032118 GJB7;C6orf162 -0.65 -9.75 -0.47 6.84e-20 Monocyte percentage of white cells; CRC trans rs11098499 0.863 rs12502389 chr4:120454191 A/G cg25214090 chr10:38739885 LOC399744 0.65 10.07 0.49 5.96e-21 Corneal astigmatism; CRC trans rs3733585 0.699 rs7699609 chr4:9961059 A/G cg26043149 chr18:55253948 FECH -0.5 -7.62 -0.39 2.81e-13 Cleft plate (environmental tobacco smoke interaction); CRC cis rs1707322 0.789 rs10789473 chr1:46248131 C/T cg06784218 chr1:46089804 CCDC17 0.6 10.93 0.52 6.45e-24 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC trans rs9858542 0.953 rs11710037 chr3:49675334 C/G cg21659725 chr3:3221576 CRBN -0.69 -9.07 -0.45 1.1e-17 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs3767633 0.800 rs2880055 chr1:161922365 C/T cg09175582 chr1:161736000 ATF6 0.61 5.79 0.3 1.6e-8 IgG glycosylation; CRC cis rs7246657 0.943 rs10405064 chr19:37861861 C/T cg23950597 chr19:37808831 NA -0.54 -6.5 -0.34 2.93e-10 Coronary artery calcification; CRC cis rs669446 0.533 rs3862228 chr1:44196945 C/T cg12908607 chr1:44402522 ARTN -0.34 -5.88 -0.31 9.99e-9 Amyotrophic lateral sclerosis (age of onset); CRC cis rs7824557 0.606 rs2736264 chr8:11186639 G/C cg20542592 chr8:11973495 FAM66D -0.33 -5.64 -0.3 3.63e-8 Retinal vascular caliber; CRC cis rs8058578 1.000 rs8051050 chr16:30687909 A/G cg00531865 chr16:30841666 NA -0.44 -5.89 -0.31 9.36e-9 Multiple myeloma; CRC cis rs17376456 0.877 rs10066791 chr5:93350255 G/T cg21475434 chr5:93447410 FAM172A 0.81 7.79 0.39 8.63e-14 Diabetic retinopathy; CRC cis rs1008375 1.000 rs10805358 chr4:17652450 A/C cg15017067 chr4:17643749 FAM184B 0.35 5.62 0.3 4.07e-8 Parasitemia in Tripanosoma cruzi seropositivity; CRC trans rs1997103 0.954 rs2030807 chr7:55378485 A/G cg20935933 chr6:143382018 AIG1 0.54 6.89 0.36 2.84e-11 QRS interval (sulfonylurea treatment interaction); CRC cis rs11212617 1.000 rs2356801 chr11:108281999 G/A cg01991180 chr11:108092276 ATM;NPAT 0.41 5.97 0.31 6.23e-9 Response to metformin in type 2 diabetes (glycemic); CRC cis rs3008870 0.755 rs1024230 chr1:67512920 A/C cg08660285 chr1:67390436 MIER1;WDR78 0.6 8.51 0.42 6.09e-16 Lymphocyte percentage of white cells; CRC trans rs11098499 0.863 rs1155576 chr4:120450159 A/C cg25214090 chr10:38739885 LOC399744 0.65 10.21 0.49 1.98e-21 Corneal astigmatism; CRC cis rs6121246 0.954 rs6060992 chr20:30431255 G/T cg18721089 chr20:30220636 NA -0.36 -5.82 -0.31 1.39e-8 Mean corpuscular hemoglobin; CRC cis rs8180040 0.629 rs7426969 chr3:47091355 T/C cg27129171 chr3:47204927 SETD2 0.73 11.44 0.53 9.82e-26 Colorectal cancer; CRC cis rs9287719 0.967 rs10454738 chr2:10742049 G/A cg00105475 chr2:10696890 NA 0.45 7.3 0.37 2.19e-12 Prostate cancer; CRC cis rs189798 1.000 rs189798 chr8:8990577 A/G cg06636001 chr8:8085503 FLJ10661 -0.45 -6.19 -0.32 1.75e-9 Myopia (pathological); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg19670317 chr17:8093380 C17orf59 0.45 6.48 0.34 3.37e-10 Response to antipsychotic treatment; CRC cis rs889398 0.771 rs8048550 chr16:69891759 T/G cg00738113 chr16:70207722 CLEC18C -0.37 -6.28 -0.33 1.08e-9 Body mass index; CRC cis rs881375 0.715 rs11794516 chr9:123640230 A/G cg09419670 chr9:123605666 PSMD5;LOC253039 0.52 8.08 0.41 1.24e-14 Rheumatoid arthritis; CRC cis rs6598955 0.671 rs11247880 chr1:26568926 G/A cg04990556 chr1:26633338 UBXN11 0.55 5.67 0.3 3.15e-8 Obesity-related traits; CRC cis rs4555082 1.000 rs7146643 chr14:105757392 A/G cg18132624 chr14:105716052 BTBD6;BRF1 -0.43 -7.54 -0.38 4.66e-13 Mean platelet volume;Platelet distribution width; CRC cis rs10504229 0.683 rs11786523 chr8:58131319 G/C cg02725872 chr8:58115012 NA -0.64 -11.55 -0.54 3.85e-26 Developmental language disorder (linguistic errors); CRC cis rs1044826 0.619 rs6439856 chr3:139134868 A/T cg15131784 chr3:139108705 COPB2 -0.41 -5.95 -0.31 6.73e-9 Obesity-related traits; CRC cis rs3820068 0.603 rs72645900 chr1:15931980 A/T cg24675056 chr1:15929824 NA 0.53 7.29 0.37 2.38e-12 Systolic blood pressure; CRC trans rs1005277 0.579 rs2472181 chr10:38386764 T/C cg27523141 chr10:43048294 ZNF37B 0.49 7.21 0.37 3.88e-12 Extrinsic epigenetic age acceleration; CRC cis rs7107174 1.000 rs4945267 chr11:78037933 G/A cg02023728 chr11:77925099 USP35 0.48 7.27 0.37 2.71e-12 Testicular germ cell tumor; CRC cis rs875971 0.862 rs1860469 chr7:66106875 A/G cg12463550 chr7:65579703 CRCP -0.45 -5.96 -0.31 6.34e-9 Aortic root size; CRC cis rs7727544 0.735 rs2631370 chr5:131703776 T/C cg21138405 chr5:131827807 IRF1 0.32 5.69 0.3 2.75e-8 Blood metabolite levels; CRC trans rs561341 0.831 rs11658469 chr17:30206426 T/C cg20587970 chr11:113659929 NA 0.9 11.01 0.52 3.3e-24 Hip circumference adjusted for BMI; CRC cis rs11758351 0.660 rs113208674 chr6:26210465 C/G cg08260959 chr6:26240920 HIST1H4F -0.36 -5.74 -0.3 2.16e-8 Gout;Renal underexcretion gout; CRC cis rs11155671 0.546 rs1999633 chr6:150187712 C/T cg05861140 chr6:150128134 PCMT1 -0.38 -5.81 -0.3 1.5e-8 Testicular germ cell tumor; CRC cis rs1129187 0.755 rs9471986 chr6:42944127 A/G cg21280719 chr6:42927975 GNMT -0.46 -10.21 -0.49 1.87e-21 Alzheimer's disease in APOE e4+ carriers; CRC cis rs66573146 0.572 rs66611116 chr4:6953270 A/G cg00086871 chr4:6988644 TBC1D14 0.93 8.92 0.44 3.4e-17 Granulocyte percentage of myeloid white cells; CRC cis rs9470366 0.527 rs4711456 chr6:36632482 C/T cg08179530 chr6:36648295 CDKN1A -0.56 -8.25 -0.41 3.91e-15 QRS duration; CRC cis rs1799949 1.000 rs8176273 chr17:41211653 A/G cg01879757 chr17:41196368 BRCA1 -0.41 -6.11 -0.32 2.79e-9 Menopause (age at onset); CRC cis rs11212617 1.000 rs7946955 chr11:108284833 A/G cg12106634 chr11:108092400 ATM;NPAT 0.44 6.62 0.34 1.47e-10 Response to metformin in type 2 diabetes (glycemic); CRC trans rs783540 0.967 rs2567635 chr15:83262181 T/G cg18393722 chr15:85113863 UBE2QP1 -0.38 -6.43 -0.33 4.53e-10 Schizophrenia; CRC cis rs28386778 0.897 rs2584601 chr17:61940977 T/C cg22520471 chr17:61851767 DDX42;CCDC47 0.73 11.41 0.53 1.24e-25 Prudent dietary pattern; CRC cis rs7617773 0.925 rs6442105 chr3:48182326 A/G cg11946769 chr3:48343235 NME6 -0.52 -7.2 -0.37 4.19e-12 Coronary artery disease; CRC cis rs782590 0.967 rs58003472 chr2:55797507 T/C cg18811423 chr2:55921094 PNPT1 0.79 14.73 0.63 4.49e-38 Metabolic syndrome; CRC cis rs9837602 1.000 rs6790535 chr3:99807735 G/A cg07805332 chr3:99536008 MIR548G;C3orf26 -0.5 -6.68 -0.35 1.05e-10 Breast cancer; CRC cis rs7954584 0.567 rs7132055 chr12:122346034 A/G cg21171335 chr12:122356390 WDR66 -0.39 -5.9 -0.31 8.95e-9 Mean corpuscular volume; CRC trans rs4332037 0.539 rs4470910 chr7:2071723 C/T cg11693508 chr17:37793320 STARD3 0.61 7.24 0.37 3.18e-12 Bipolar disorder; CRC cis rs796364 0.806 rs34582889 chr2:201010527 A/G cg25936922 chr2:200820526 C2orf60;C2orf47 -0.57 -5.67 -0.3 3.07e-8 Schizophrenia; CRC cis rs6840360 1.000 rs6535811 chr4:152598992 C/T cg09659197 chr4:152720779 NA 0.52 11.26 0.53 4.19e-25 Intelligence (multi-trait analysis); CRC cis rs870825 0.616 rs1401362 chr4:185643775 G/A cg04058563 chr4:185651563 MLF1IP 0.72 9.42 0.46 8.17e-19 Blood protein levels; CRC cis rs35883536 0.647 rs55728953 chr1:101046863 T/C cg06223162 chr1:101003688 GPR88 -0.34 -6.15 -0.32 2.21e-9 Monocyte count; CRC trans rs7647973 0.626 rs1996664 chr3:49878395 A/G cg21659725 chr3:3221576 CRBN 0.66 7.31 0.37 2e-12 Menarche (age at onset); CRC cis rs6951245 0.554 rs10270249 chr7:1151886 G/T cg20603222 chr7:1096387 C7orf50;GPR146 -0.44 -5.74 -0.3 2.19e-8 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs1843834 0.823 rs2129610 chr2:225505345 G/A cg22455342 chr2:225449267 CUL3 0.46 6.14 0.32 2.41e-9 IgE levels in asthmatics (D.p. specific); CRC cis rs7615952 0.599 rs12496921 chr3:125701948 C/G cg04553112 chr3:125709451 NA -0.5 -5.7 -0.3 2.61e-8 Blood pressure (smoking interaction); CRC cis rs4332037 0.624 rs56256289 chr7:1892529 C/T cg23378565 chr7:2036160 MAD1L1 -0.39 -6.05 -0.32 3.95e-9 Bipolar disorder; CRC cis rs7829975 0.688 rs7827182 chr8:8380471 C/G cg06636001 chr8:8085503 FLJ10661 0.52 7.96 0.4 2.85e-14 Mood instability; CRC cis rs2408955 0.521 rs10875753 chr12:48557141 C/T cg00601486 chr12:48723148 H1FNT 0.35 6.72 0.35 7.85e-11 Glycated hemoglobin levels; CRC trans rs925098 0.577 rs2724470 chr4:17996046 A/G cg07920855 chr1:185286635 IVNS1ABP -0.43 -6.24 -0.33 1.35e-9 Birth weight;Height; CRC cis rs68170813 0.559 rs7803290 chr7:106907353 T/C cg02696742 chr7:106810147 HBP1 -0.61 -6.7 -0.35 9.26e-11 Coronary artery disease; CRC cis rs7811142 1.000 rs73161759 chr7:100009994 T/C cg00814883 chr7:100076585 TSC22D4 -0.73 -9.37 -0.46 1.17e-18 Platelet count; CRC cis rs968567 0.638 rs7943728 chr11:61547068 G/A cg25303599 chr11:61595807 FADS2 -0.49 -6.53 -0.34 2.47e-10 Blood metabolite levels;Rheumatoid arthritis;Vitiligo;Glycerophospholipid levels; CRC cis rs72730918 0.564 rs12708427 chr15:51909555 C/T cg14296394 chr15:51910925 DMXL2 -0.46 -6.16 -0.32 2.08e-9 Intelligence (multi-trait analysis); CRC cis rs2732480 0.577 rs2634684 chr12:48730875 C/T cg24011408 chr12:48396354 COL2A1 -0.42 -5.67 -0.3 3.16e-8 Hemoglobin concentration;Red blood cell count;Hematocrit; CRC cis rs9291683 0.597 rs11723016 chr4:10126189 A/G cg00071950 chr4:10020882 SLC2A9 -0.49 -8.32 -0.42 2.38e-15 Bone mineral density; CRC trans rs2303319 0.504 rs1023835 chr2:162593973 A/G cg20024234 chr21:43431083 ZNF295 -0.66 -5.99 -0.31 5.57e-9 Cognitive function; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg15731816 chr14:75230414 YLPM1 0.48 6.24 0.33 1.33e-9 Thyroid stimulating hormone; CRC cis rs9894429 0.934 rs35868252 chr17:79575472 C/G cg18240062 chr17:79603768 NPLOC4 -0.56 -9.34 -0.46 1.54e-18 Eye color traits; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg14134710 chr21:44313311 NDUFV3 0.46 6.4 0.33 5.25e-10 Anxiety disorder; CRC cis rs7618915 0.501 rs3755798 chr3:52741160 G/A cg10802521 chr3:52805072 NEK4 -0.57 -8.91 -0.44 3.68e-17 Bipolar disorder; CRC cis rs6570726 0.935 rs12663205 chr6:145818378 G/A cg23711669 chr6:146136114 FBXO30 0.68 12.16 0.56 2.33e-28 Lobe attachment (rater-scored or self-reported); CRC cis rs875971 0.660 rs801192 chr7:66031952 C/G cg18876405 chr7:65276391 NA -0.6 -10.83 -0.51 1.4e-23 Aortic root size; CRC cis rs7772486 0.869 rs2777473 chr6:146301494 G/A cg23711669 chr6:146136114 FBXO30 0.61 10.29 0.49 1.04e-21 Lobe attachment (rater-scored or self-reported); CRC cis rs6502050 0.835 rs11077981 chr17:80147243 C/T cg09264619 chr17:80180166 NA -0.37 -6.17 -0.32 2.04e-9 Life satisfaction; CRC cis rs1862618 0.573 rs185220 chr5:56205357 A/G cg20203395 chr5:56204925 C5orf35 -0.79 -9.41 -0.46 8.61e-19 Initial pursuit acceleration; CRC cis rs2836950 0.545 rs8132424 chr21:40584412 A/T cg17971929 chr21:40555470 PSMG1 0.58 8.43 0.42 1.13e-15 Menarche (age at onset); CRC cis rs2727020 0.521 rs1909220 chr11:49572109 T/C cg25886479 chr11:50257625 LOC441601 -0.34 -5.8 -0.3 1.56e-8 Coronary artery disease; CRC cis rs9443189 0.527 rs775059 chr6:76370130 G/T cg01950844 chr6:76311363 SENP6 0.73 9.76 0.47 6.14e-20 Prostate cancer; CRC trans rs561341 1.000 rs72821971 chr17:30269343 T/G cg27661571 chr11:113659931 NA -0.97 -11.28 -0.53 3.75e-25 Hip circumference adjusted for BMI; CRC cis rs6500602 0.701 rs8129 chr16:4562351 A/G cg06139259 chr16:4526053 HMOX2;NMRAL1 0.45 5.92 0.31 8.13e-9 Schizophrenia; CRC cis rs6141769 0.518 rs6058847 chr20:31324135 C/T cg13636640 chr20:31349939 DNMT3B -0.41 -6.05 -0.32 3.89e-9 Subjective well-being; CRC trans rs1656966 1.000 rs1656966 chr3:186466252 C/T cg03203239 chr2:74735315 PCGF1 0.43 6.72 0.35 7.99e-11 Myopia (pathological); CRC cis rs6570726 0.791 rs427128 chr6:145865917 T/C cg13319975 chr6:146136371 FBXO30 -0.47 -7.02 -0.36 1.26e-11 Lobe attachment (rater-scored or self-reported); CRC cis rs73206853 0.764 rs73206868 chr12:110816835 G/T cg12870014 chr12:110450643 ANKRD13A 0.84 10.0 0.48 1e-20 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg07540722 chr2:70056697 GMCL1 0.46 6.4 0.33 5.42e-10 Anxiety disorder; CRC cis rs921968 0.643 rs10187066 chr2:219514759 A/G cg02176678 chr2:219576539 TTLL4 0.51 8.06 0.41 1.38e-14 Mean corpuscular hemoglobin concentration; CRC cis rs9303401 1.000 rs9303401 chr17:56847945 C/T cg12560992 chr17:57184187 TRIM37 0.44 5.83 0.31 1.35e-8 Cognitive test performance; CRC cis rs77633900 0.614 rs280008 chr15:77011815 T/C cg21673338 chr15:77095150 SCAPER -0.76 -8.0 -0.4 2.14e-14 Non-glioblastoma glioma;Glioma; CRC cis rs10504073 0.669 rs341799 chr8:50036574 A/G cg00325661 chr8:49890786 NA 0.42 7.56 0.38 4.07e-13 Blood metabolite ratios; CRC cis rs13191362 1.000 rs35575481 chr6:163007746 T/A cg23758597 chr6:163146217 PARK2 -0.56 -6.17 -0.32 2.03e-9 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs17345786 0.906 rs58835747 chr3:101243634 T/C cg11279151 chr3:101281821 RG9MTD1 -0.65 -7.92 -0.4 3.57e-14 Colonoscopy-negative controls vs population controls; CRC cis rs7584330 0.518 rs74003104 chr2:238446823 C/T cg08992911 chr2:238395768 MLPH 0.61 6.25 0.33 1.26e-9 Prostate cancer; CRC cis rs9549367 0.713 rs2146750 chr13:113822530 A/G cg18105134 chr13:113819100 PROZ 0.77 11.02 0.52 2.96e-24 Platelet distribution width; CRC cis rs2011503 0.941 rs113145184 chr19:19419984 T/C cg11584989 chr19:19387371 SF4 0.56 6.43 0.33 4.5e-10 Bipolar disorder; CRC cis rs7224685 0.501 rs781825 chr17:3966064 A/G cg09597638 chr17:3907349 NA 0.63 11.42 0.53 1.17e-25 Type 2 diabetes; CRC cis rs8044868 0.586 rs8182213 chr16:72080005 C/T cg23815491 chr16:72088622 HP 0.5 7.23 0.37 3.35e-12 Body mass index (change over time) in cancer or chronic obstructive pulmonary disease;Body mass index (change over time) in cancer; CRC cis rs2836974 0.897 rs2026267 chr21:40711477 C/A cg06238570 chr21:40685208 BRWD1 0.7 9.28 0.46 2.28e-18 Cognitive function; CRC cis rs875971 0.964 rs55748098 chr7:65763618 T/C cg11764359 chr7:65958608 NA -0.61 -9.98 -0.48 1.19e-20 Aortic root size; CRC cis rs2932538 0.922 rs3790611 chr1:113067792 A/G cg22162597 chr1:113214053 CAPZA1 0.71 9.88 0.48 2.52e-20 Systolic blood pressure;Diastolic blood pressure;Hypertension;Blood pressure; CRC cis rs6952808 0.600 rs2895202 chr7:2131829 T/C cg04267008 chr7:1944627 MAD1L1 -0.68 -9.31 -0.46 1.9e-18 Bipolar disorder and schizophrenia; CRC cis rs11212617 0.935 rs227075 chr11:108218196 A/G cg01991180 chr11:108092276 ATM;NPAT 0.4 5.8 0.3 1.6e-8 Response to metformin in type 2 diabetes (glycemic); CRC cis rs8058578 0.945 rs885107 chr16:30672719 T/C cg00531865 chr16:30841666 NA -0.44 -6.03 -0.32 4.29e-9 Multiple myeloma; CRC cis rs4148883 0.645 rs2851264 chr4:100029715 C/T cg13256891 chr4:100009986 ADH5 0.45 6.43 0.33 4.36e-10 Alcohol dependence; CRC cis rs7666738 0.716 rs6817529 chr4:99023213 T/C cg17366294 chr4:99064904 C4orf37 0.43 7.29 0.37 2.28e-12 Colonoscopy-negative controls vs population controls; CRC cis rs873946 0.648 rs12782123 chr10:134554662 G/A cg26818010 chr10:134567672 INPP5A -0.7 -8.97 -0.44 2.3e-17 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CRC cis rs10504229 0.906 rs113857287 chr8:58191683 T/C cg22535103 chr8:58192502 C8orf71 -0.81 -11.95 -0.55 1.34e-27 Developmental language disorder (linguistic errors); CRC cis rs2404602 0.563 rs12914005 chr15:76765667 A/G cg03037974 chr15:76606532 NA 0.66 11.61 0.54 2.33e-26 Blood metabolite levels; CRC cis rs12142240 0.660 rs6679080 chr1:46819779 A/T cg00530320 chr1:46809349 NSUN4 0.58 7.93 0.4 3.43e-14 Menopause (age at onset); CRC cis rs801193 0.548 rs2109297 chr7:66122384 G/A cg00343986 chr7:65444356 GUSB -0.45 -6.2 -0.32 1.7e-9 Aortic root size; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg21647170 chr7:56119546 CCT6A;PSPH 0.43 6.03 0.32 4.35e-9 Response to antipsychotic treatment; CRC cis rs1691799 0.899 rs903589 chr12:66745835 C/T cg16791601 chr12:66731901 HELB -0.69 -11.91 -0.55 1.95e-27 White blood cell count (basophil); CRC cis rs28386778 0.897 rs2665823 chr17:61885917 G/A cg06873352 chr17:61820015 STRADA 0.77 14.51 0.62 3.1e-37 Prudent dietary pattern; CRC cis rs6761276 0.727 rs6743376 chr2:113832333 C/A cg09040174 chr2:113837401 NA 0.5 7.0 0.36 1.49e-11 Protein quantitative trait loci; CRC cis rs3736594 0.959 rs10201247 chr2:27974971 A/G cg27432699 chr2:27873401 GPN1 -0.6 -8.31 -0.42 2.52e-15 Fasting blood glucose;Fasting blood glucose (BMI interaction); CRC cis rs9322193 0.884 rs1125 chr6:149979416 G/A cg05861140 chr6:150128134 PCMT1 -0.39 -5.98 -0.31 5.84e-9 Lung cancer; CRC cis rs8141797 0.901 rs5751810 chr22:24566579 G/A cg20894457 chr22:24584366 SUSD2 0.66 6.51 0.34 2.77e-10 Amyotrophic lateral sclerosis;Coronary artery disease; CRC cis rs7618915 0.547 rs12496634 chr3:52709259 A/C cg08222913 chr3:52553049 STAB1 -0.34 -6.23 -0.32 1.45e-9 Bipolar disorder; CRC cis rs2976388 1.000 rs2920297 chr8:143763083 A/G cg20041105 chr8:143859282 LYNX1 -0.32 -5.65 -0.3 3.45e-8 Urinary tract infection frequency; CRC cis rs11030122 0.661 rs4910877 chr11:4062153 A/G cg18678763 chr11:4115507 RRM1 -0.45 -7.33 -0.37 1.81e-12 Mean platelet volume;Platelet distribution width; CRC cis rs7223966 1.000 rs8075061 chr17:61804723 A/G cg05941027 chr17:61774174 LIMD2 0.36 6.4 0.33 5.23e-10 Hip circumference adjusted for BMI;Body mass index; CRC cis rs35306767 0.903 rs17159950 chr10:875287 T/G cg26597838 chr10:835615 NA 0.96 11.44 0.53 9.55e-26 Eosinophil percentage of granulocytes; CRC cis rs9463078 0.764 rs9357464 chr6:44952441 T/C cg25276700 chr6:44698697 NA -0.28 -7.13 -0.37 6.58e-12 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; CRC cis rs929354 0.713 rs6459733 chr7:156930550 G/C cg17757837 chr7:157058334 UBE3C 0.75 12.46 0.57 1.85e-29 Body mass index; CRC cis rs11190604 0.767 rs11190531 chr10:102187310 T/A cg16342193 chr10:102329863 NA -0.37 -6.0 -0.31 5.3300000000000004e-09 Palmitoleic acid (16:1n-7) levels; CRC cis rs1971762 0.509 rs1247955 chr12:53964133 G/T cg06632207 chr12:54070931 ATP5G2 -0.49 -8.29 -0.42 2.89e-15 Height; CRC cis rs4692589 1.000 rs4692589 chr4:170935245 C/T cg19918862 chr4:170955249 NA -0.36 -5.97 -0.31 6.26e-9 Anxiety disorder; CRC cis rs4819052 0.851 rs7275870 chr21:46671214 C/T cg19498844 chr21:46707878 POFUT2;LOC642852 0.75 10.82 0.51 1.49e-23 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs10504229 0.861 rs116964504 chr8:58185354 A/C cg02290350 chr8:58132656 NA -0.42 -5.96 -0.31 6.62e-9 Developmental language disorder (linguistic errors); CRC cis rs2734839 0.964 rs1076563 chr11:113295909 A/C cg14159747 chr11:113255604 NA 0.46 7.95 0.4 2.96e-14 Information processing speed; CRC cis rs2408955 0.522 rs4760612 chr12:48421856 C/T cg24011408 chr12:48396354 COL2A1 -0.42 -6.12 -0.32 2.6e-9 Glycated hemoglobin levels; CRC cis rs12762955 0.561 rs11253567 chr10:1054444 A/G cg20503657 chr10:835505 NA 0.5 6.85 0.35 3.66e-11 Response to angiotensin II receptor blocker therapy; CRC cis rs2204008 0.683 rs11519834 chr12:38053575 T/A cg13010199 chr12:38710504 ALG10B 0.44 5.64 0.3 3.74e-8 Bladder cancer; CRC cis rs533581 0.873 rs579740 chr16:88973937 A/G cg16701003 chr16:89028210 CBFA2T3 -0.47 -7.55 -0.38 4.35e-13 Social autistic-like traits; CRC cis rs2976388 0.578 rs34956412 chr8:143822028 C/T cg10596483 chr8:143751796 JRK -0.49 -6.69 -0.35 9.65e-11 Urinary tract infection frequency; CRC cis rs6456156 0.586 rs4710176 chr6:167491639 T/C cg07741184 chr6:167504864 NA 0.43 7.22 0.37 3.66e-12 Primary biliary cholangitis; CRC cis rs4853012 0.838 rs61521879 chr2:74346208 T/C cg01017244 chr2:74357527 NA 0.68 9.56 0.47 2.9e-19 Gestational age at birth (maternal effect); CRC cis rs769267 0.899 rs3934667 chr19:19431423 T/G cg02546618 chr19:19431379 KIAA0892;SF4 -0.48 -6.75 -0.35 6.73e-11 Tonsillectomy; CRC cis rs34172651 0.517 rs34172679 chr16:24840381 C/T cg00339695 chr16:24857497 SLC5A11 0.38 7.29 0.37 2.34e-12 Intelligence (multi-trait analysis); CRC cis rs10504229 0.520 rs55967509 chr8:57992448 A/G cg02725872 chr8:58115012 NA -0.44 -6.46 -0.34 3.84e-10 Developmental language disorder (linguistic errors); CRC cis rs2019137 0.560 rs7578633 chr2:113978650 C/T cg12889195 chr2:113992843 PAX8;LOC440839;LOC654433 0.69 10.38 0.5 5.23e-22 Lymphocyte counts; CRC cis rs10504229 0.683 rs6982990 chr8:58115275 C/T cg02725872 chr8:58115012 NA 0.59 10.91 0.52 7.36e-24 Developmental language disorder (linguistic errors); CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg09070503 chr1:36107132 PSMB2 0.44 5.96 0.31 6.5e-9 Anxiety disorder; CRC cis rs6499255 0.951 rs61310815 chr16:69701239 A/T cg04110750 chr16:69646130 NFAT5 -0.54 -7.46 -0.38 7.78e-13 IgE levels; CRC cis rs7107770 0.663 rs6590136 chr11:125073708 A/G cg27629782 chr11:125073726 PKNOX2 0.5 7.13 0.37 6.37e-12 Photic sneeze reflex; CRC cis rs5750830 0.649 rs4384886 chr22:39793766 C/T cg11247378 chr22:39784982 NA -0.5 -10.11 -0.49 4.04e-21 Intelligence (multi-trait analysis); CRC cis rs35264875 0.950 rs35337391 chr11:68854012 A/G cg23740940 chr11:68924746 NA 0.44 5.7 0.3 2.62e-8 Blond vs. brown hair color; CRC cis rs9913156 0.515 rs11658808 chr17:4577112 C/T cg00122941 chr17:4613640 ARRB2 -0.47 -6.4 -0.33 5.47e-10 Lymphocyte counts; CRC cis rs9420 0.961 rs11607056 chr11:57496820 C/T cg23127183 chr11:57508653 C11orf31 -0.53 -7.16 -0.37 5.32e-12 Schizophrenia; CRC cis rs35306767 0.715 rs17293580 chr10:1034895 T/C cg20503657 chr10:835505 NA 0.9 10.57 0.5 1.14e-22 Eosinophil percentage of granulocytes; CRC trans rs9771228 0.864 rs215606 chr7:32337443 C/T cg02979224 chr7:93204462 CALCR 0.36 6.33 0.33 7.9e-10 Cognitive ability;Verbal-numerical reasoning; CRC cis rs36715 1.000 rs36702 chr5:127552723 A/T cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.59 7.52 0.38 5.25e-13 Breast cancer; CRC cis rs172166 0.694 rs203877 chr6:28048624 T/C cg12172441 chr6:28176163 NA 0.52 7.11 0.37 7.2e-12 Cardiac Troponin-T levels; CRC cis rs9457247 0.508 rs9457268 chr6:167503639 A/T cg07741184 chr6:167504864 NA 0.37 6.7 0.35 9.15e-11 Crohn's disease; CRC cis rs748404 0.697 rs1095389 chr15:43566671 G/A cg02155558 chr15:43621948 ADAL;LCMT2 0.42 6.24 0.33 1.32e-9 Lung cancer; CRC cis rs875971 0.545 rs73376394 chr7:65637681 C/T cg02869306 chr7:64672164 INTS4L1 -0.41 -6.19 -0.32 1.83e-9 Aortic root size; CRC cis rs9894429 0.505 rs35570626 chr17:79611084 A/G cg13777783 chr17:79615861 NA -0.3 -5.67 -0.3 3.13e-8 Eye color traits; CRC cis rs11758351 0.587 rs2050950 chr6:26234883 A/G cg01420254 chr6:26195488 NA 0.73 8.07 0.41 1.31e-14 Gout;Renal underexcretion gout; CRC cis rs9303401 0.614 rs62084387 chr17:57148027 C/T cg02118635 chr17:56770003 RAD51C;TEX14 0.8 9.09 0.45 9.49e-18 Cognitive test performance; CRC cis rs6662572 0.737 rs4474301 chr1:46255272 A/G cg03123370 chr1:45965343 CCDC163P;MMACHC -0.49 -6.35 -0.33 7.18e-10 Blood protein levels; CRC cis rs34779708 0.931 rs7099036 chr10:35349574 C/T cg03585969 chr10:35415529 CREM 0.59 7.86 0.4 5.38e-14 Inflammatory bowel disease;Crohn's disease; CRC cis rs9311474 0.581 rs4687626 chr3:52569098 G/A cg08222913 chr3:52553049 STAB1 -0.37 -7.11 -0.36 7.38e-12 Electroencephalogram traits; CRC cis rs2462686 1.000 rs2132571 chr7:45961674 C/T cg23193639 chr7:45961078 IGFBP3 -0.36 -5.62 -0.3 4.03e-8 Major depressive disorder; CRC cis rs4713118 0.513 rs149942 chr6:28001610 T/C cg15786705 chr6:28176104 NA 0.61 8.9 0.44 3.91e-17 Parkinson's disease; CRC cis rs11212617 1.000 rs11212619 chr11:108289167 A/G cg01991180 chr11:108092276 ATM;NPAT 0.4 5.8 0.3 1.59e-8 Response to metformin in type 2 diabetes (glycemic); CRC cis rs2721195 0.967 rs1480000 chr8:145702007 C/T cg26752003 chr8:145688521 CYHR1 0.64 11.29 0.53 3.24e-25 Age at first birth; CRC cis rs1577917 1.000 rs12661204 chr6:86678586 C/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.58 -7.19 -0.37 4.49e-12 Response to antipsychotic treatment; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg10605791 chr12:122242589 SETD1B;LOC338799 0.38 6.28 0.33 1.05e-9 Liver disease severity in Alagille syndrome; CRC cis rs736408 0.509 rs2590838 chr3:52622086 G/A cg05564831 chr3:52568323 NT5DC2 0.33 5.6 0.3 4.41e-8 Bipolar disorder; CRC cis rs454510 0.816 rs838987 chr1:120176127 A/G cg11530693 chr1:120165357 ZNF697 0.48 6.15 0.32 2.19e-9 Alcohol dependence or chronic alcoholic pancreatitis or alcohol-related liver cirrhosis; CRC cis rs2882667 0.898 rs2043272 chr5:138390631 A/C cg09476006 chr5:138032270 NA 0.41 6.66 0.34 1.13e-10 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs67311347 1.000 rs12488805 chr3:40422869 C/T cg09455208 chr3:40491958 NA 0.49 9.42 0.46 8.2e-19 Renal cell carcinoma; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg03648789 chr2:38304037 CYP1B1 0.41 6.12 0.32 2.67e-9 Response to antipsychotic treatment; CRC cis rs172166 0.694 rs203893 chr6:28062066 C/A cg26587870 chr6:27730563 NA -0.37 -5.6 -0.3 4.46e-8 Cardiac Troponin-T levels; CRC cis rs2404602 0.647 rs12913024 chr15:77145216 C/T cg03037974 chr15:76606532 NA -0.53 -7.43 -0.38 9.63e-13 Blood metabolite levels; CRC cis rs73206853 0.764 rs7312469 chr12:110889072 A/G cg12870014 chr12:110450643 ANKRD13A 0.75 8.21 0.41 5.25e-15 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC cis rs1448094 0.511 rs61930037 chr12:86154503 G/A cg00310523 chr12:86230176 RASSF9 0.41 6.62 0.34 1.5e-10 Major depressive disorder; CRC cis rs25422 0.878 rs55894300 chr6:118982076 T/A cg18833306 chr6:118973337 C6orf204 0.49 6.05 0.32 4.02e-9 Renal cell carcinoma; CRC cis rs7584330 0.740 rs10184904 chr2:238428186 G/C cg16989719 chr2:238392110 NA -0.38 -7.43 -0.38 9.71e-13 Prostate cancer; CRC cis rs5769765 0.773 rs9616383 chr22:50313014 T/C cg04121214 chr22:50244548 NA 0.42 5.89 0.31 9.4e-9 Schizophrenia; CRC cis rs10504229 0.679 rs17804870 chr8:58158071 A/G cg24829409 chr8:58192753 C8orf71 -0.71 -8.43 -0.42 1.08e-15 Developmental language disorder (linguistic errors); CRC cis rs875622 0.556 rs4808047 chr19:16527834 T/C cg10248733 chr19:16607483 C19orf44;CALR3 -0.58 -6.65 -0.34 1.19e-10 White matter integrity;Neutrophil percentage of white cells; CRC cis rs965469 0.843 rs6051842 chr20:3397434 T/C cg25506879 chr20:3388711 C20orf194 -0.41 -6.38 -0.33 5.94e-10 IFN-related cytopenia; CRC cis rs3091242 0.935 rs4233043 chr1:25765483 A/G cg27572855 chr1:25598939 RHD 0.35 6.11 0.32 2.79e-9 Erythrocyte sedimentation rate; CRC cis rs10865541 0.902 rs6739163 chr2:3419011 G/A cg22182287 chr2:3452347 TTC15 0.38 6.06 0.32 3.71e-9 Obesity-related traits; CRC cis rs2243480 1.000 rs35396113 chr7:65495461 C/T cg12463550 chr7:65579703 CRCP 0.71 6.57 0.34 1.95e-10 Diabetic kidney disease; CRC cis rs4730250 0.554 rs76257331 chr7:106916279 G/A cg23293999 chr7:106826042 HBP1 -0.54 -5.7 -0.3 2.6e-8 Osteoarthritis; CRC cis rs642803 0.613 rs565427 chr11:65532825 G/A cg27068330 chr11:65405492 SIPA1 0.45 5.9 0.31 8.9e-9 Urate levels; CRC trans rs4650994 1.000 rs10798619 chr1:178532517 A/G cg05059571 chr16:84539110 KIAA1609 -0.43 -6.52 -0.34 2.58e-10 HDL cholesterol levels;HDL cholesterol; CRC cis rs116095464 0.558 rs6875291 chr5:264192 T/C cg22857025 chr5:266934 NA -1.25 -16.78 -0.68 4.42e-46 Breast cancer; CRC cis rs12912251 0.591 rs4924291 chr15:39000484 A/C cg10631289 chr15:39006617 NA 0.49 6.04 0.32 4.14e-9 Bipolar disorder;Bipolar disorder or major depressive disorder (combined); CRC cis rs6879260 1.000 rs7725605 chr5:179732678 T/G cg26918954 chr5:179728553 GFPT2 -0.43 -7.27 -0.37 2.58e-12 Height; CRC cis rs694739 0.628 rs10897487 chr11:64140704 C/T cg02228329 chr11:64053129 BAD;GPR137 0.5 6.79 0.35 5.31e-11 Alopecia areata;Crohn's disease;Psoriasis vulgaris; CRC cis rs10504229 1.000 rs58053450 chr8:58173348 T/C cg01721255 chr8:58191610 C8orf71 0.49 6.17 0.32 2e-9 Developmental language disorder (linguistic errors); CRC cis rs2281845 0.507 rs942703 chr1:201092979 A/G cg08885800 chr1:201084119 NA -0.41 -5.8 -0.3 1.52e-8 Permanent tooth development; CRC cis rs4713118 0.513 rs149950 chr6:28033039 T/G cg10876282 chr6:28092338 ZSCAN16 0.47 6.43 0.33 4.62e-10 Parkinson's disease; CRC cis rs2380220 0.808 rs72922390 chr6:95934317 G/A cg04719120 chr6:96025338 MANEA -0.55 -6.0 -0.31 5.09e-9 Behavioural disinhibition (generation interaction); CRC cis rs5758511 0.680 rs5758667 chr22:42633204 G/A cg00645731 chr22:42541494 CYP2D7P1 0.66 10.17 0.49 2.67e-21 Birth weight; CRC cis rs10504229 0.679 rs11783557 chr8:58030644 A/G cg22535103 chr8:58192502 C8orf71 -0.44 -6.15 -0.32 2.23e-9 Developmental language disorder (linguistic errors); CRC cis rs62064224 0.589 rs6505295 chr17:30687522 G/C cg25809561 chr17:30822961 MYO1D 0.52 9.16 0.45 5.78e-18 Schizophrenia; CRC cis rs6662572 0.703 rs17855317 chr1:46500613 T/C cg08644498 chr1:46502608 NA 0.46 7.28 0.37 2.47e-12 Blood protein levels; CRC cis rs9322193 0.923 rs9322204 chr6:149957183 A/C cg13206674 chr6:150067644 NUP43 0.63 9.46 0.46 5.89e-19 Lung cancer; CRC trans rs61931739 0.500 rs7489132 chr12:34539712 C/T cg26384229 chr12:38710491 ALG10B 0.68 8.8 0.44 7.69e-17 Morning vs. evening chronotype; CRC cis rs6585424 1.000 rs34148644 chr10:81923456 G/C cg11900509 chr10:81946545 ANXA11 -0.76 -9.29 -0.46 2.25e-18 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs13108904 0.875 rs1732099 chr4:1282696 T/C cg20887711 chr4:1340912 KIAA1530 -0.48 -7.18 -0.37 4.54e-12 Obesity-related traits; CRC trans rs1656966 1.000 rs1656966 chr3:186466252 C/T cg23715237 chr8:145018300 PLEC1 0.41 6.13 0.32 2.58e-9 Myopia (pathological); CRC cis rs11190604 1.000 rs2495734 chr10:102338686 G/A cg07080220 chr10:102295463 HIF1AN 0.49 5.87 0.31 1.06e-8 Palmitoleic acid (16:1n-7) levels; CRC cis rs25422 0.540 rs9481842 chr6:118974798 A/C cg15382696 chr6:118971807 C6orf204 0.45 6.46 0.34 3.71e-10 Renal cell carcinoma; CRC trans rs116095464 0.558 rs10075018 chr5:239175 G/A cg00938859 chr5:1591904 SDHAP3 0.74 7.92 0.4 3.68e-14 Breast cancer; CRC cis rs9296092 0.538 rs34222093 chr6:33519584 G/C cg13560919 chr6:33536144 NA -0.44 -6.2 -0.32 1.71e-9 Age at smoking initiation in chronic obstructive pulmonary disease; CRC cis rs2952156 1.000 rs2088126 chr17:37879030 A/G cg00129232 chr17:37814104 STARD3 -0.66 -10.71 -0.51 3.8e-23 Asthma; CRC cis rs9311474 0.629 rs11709284 chr3:52559705 G/A cg10802521 chr3:52805072 NEK4 -0.42 -6.54 -0.34 2.39e-10 Electroencephalogram traits; CRC cis rs4481887 0.573 rs4412629 chr1:248411399 G/T cg00666640 chr1:248458726 OR2T12 0.41 6.98 0.36 1.63e-11 Common traits (Other); CRC cis rs7493 0.516 rs13233527 chr7:95068795 T/C cg17330251 chr7:94953956 PON1 -0.42 -5.87 -0.31 1.06e-8 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs4481887 0.962 rs6663952 chr1:248465682 A/G cg13385794 chr1:248469461 NA 0.39 6.91 0.36 2.51e-11 Common traits (Other); CRC cis rs72634258 0.519 rs35197830 chr1:7930983 A/G cg26816564 chr1:7831052 VAMP3 0.63 7.81 0.4 7.87e-14 Inflammatory bowel disease; CRC cis rs6952808 0.601 rs3778978 chr7:2159817 A/G cg02951883 chr7:2050386 MAD1L1 -0.69 -10.64 -0.51 6.6e-23 Bipolar disorder and schizophrenia; CRC cis rs1059312 0.808 rs12816551 chr12:129295616 T/C cg21616243 chr12:129299702 MGC16384;SLC15A4 -0.75 -13.27 -0.59 1.76e-32 Systemic lupus erythematosus; CRC cis rs3820068 0.603 rs6429769 chr1:15968610 C/G cg13390004 chr1:15929781 NA 0.48 6.84 0.35 3.87e-11 Systolic blood pressure; CRC cis rs3540 1.000 rs7173724 chr15:91036855 A/G cg22089800 chr15:90895588 ZNF774 0.45 7.34 0.38 1.7e-12 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; CRC cis rs947211 1.000 rs1775151 chr1:205745684 C/T cg26354017 chr1:205819088 PM20D1 0.43 5.91 0.31 8.4e-9 Parkinson's disease; CRC cis rs10744422 1.000 rs7959441 chr12:123363825 C/T cg25930673 chr12:123319894 HIP1R -0.54 -5.68 -0.3 2.91e-8 Schizophrenia; CRC cis rs7412746 0.611 rs10788794 chr1:150728676 T/C cg17724175 chr1:150552817 MCL1 0.48 7.04 0.36 1.12e-11 Melanoma; CRC cis rs1550582 1.000 rs16905157 chr8:135519964 C/T cg17885191 chr8:135476712 NA 0.71 8.28 0.42 3.1e-15 Educational attainment; CRC cis rs7811142 0.666 rs28401739 chr7:99905684 A/G cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.11 15.72 0.65 6.5e-42 Platelet count; CRC cis rs1401999 0.674 rs562 chr3:183637845 T/C cg01324343 chr3:183735012 ABCC5 0.63 10.04 0.48 7.12e-21 Anterior chamber depth; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg00724774 chr19:1812282 ATP8B3 0.45 7.09 0.36 8.43e-12 Liver disease severity in Alagille syndrome; CRC cis rs4926298 1.000 rs931068 chr19:13158678 A/G cg23899408 chr19:12877188 HOOK2 -0.44 -6.12 -0.32 2.73e-9 Bipolar disorder; CRC cis rs832540 0.931 rs1466008 chr5:56213406 G/C cg20203395 chr5:56204925 C5orf35 -0.41 -5.83 -0.31 1.35e-8 Coronary artery disease; CRC cis rs11864453 1.000 rs7185407 chr16:72034957 A/T cg23815491 chr16:72088622 HP -0.56 -8.21 -0.41 5.14e-15 Fibrinogen levels; CRC cis rs116095464 0.558 rs28729548 chr5:229025 C/T cg22857025 chr5:266934 NA -1.21 -16.45 -0.67 8.87e-45 Breast cancer; CRC cis rs7119 0.717 rs7180732 chr15:77829921 G/A cg27398640 chr15:77910606 LINGO1 -0.44 -7.48 -0.38 6.62e-13 Type 2 diabetes; CRC cis rs172166 0.637 rs1225595 chr6:28151340 A/T cg03623178 chr6:28175578 NA 0.84 13.06 0.58 1.07e-31 Cardiac Troponin-T levels; CRC cis rs11190604 1.000 rs11816840 chr10:102309220 G/C cg16342193 chr10:102329863 NA -0.36 -5.93 -0.31 7.49e-9 Palmitoleic acid (16:1n-7) levels; CRC cis rs3540 0.960 rs12440447 chr15:91022694 C/G cg22089800 chr15:90895588 ZNF774 0.48 7.71 0.39 1.49e-13 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; CRC cis rs6459788 0.527 rs6980250 chr7:157228710 C/T cg03453431 chr7:157225567 NA -0.54 -8.34 -0.42 2.12e-15 Epstein-Barr virus copy number in lymphoblastoid cell lines; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg15985338 chr7:6048868 PMS2;AIMP2 -0.41 -5.99 -0.31 5.54e-9 Myopia (pathological); CRC cis rs7258465 0.965 rs271622 chr19:18629277 A/G cg10790698 chr19:18539756 SSBP4 -0.46 -8.93 -0.44 3.15e-17 Breast cancer; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg25767192 chr19:52693159 PPP2R1A 0.43 6.36 0.33 6.71e-10 Intelligence (multi-trait analysis); CRC cis rs4974559 0.790 rs10012582 chr4:1324481 G/A cg02980000 chr4:1222292 CTBP1 0.51 6.44 0.33 4.24e-10 Systolic blood pressure; CRC cis rs6951245 0.572 rs60918895 chr7:1039036 C/T cg20603222 chr7:1096387 C7orf50;GPR146 -0.67 -5.92 -0.31 7.98e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs9326248 0.817 rs1242127 chr11:117076564 A/G cg11861562 chr11:117069780 TAGLN -0.43 -9.19 -0.45 4.62e-18 Blood protein levels; CRC cis rs66573146 1.000 rs28729690 chr4:6962061 C/T cg00086871 chr4:6988644 TBC1D14 0.8 6.25 0.33 1.28e-9 Granulocyte percentage of myeloid white cells; CRC trans rs6546324 0.625 rs6752799 chr2:67858503 G/A cg00907274 chr3:27498161 SLC4A7 -0.49 -6.23 -0.32 1.44e-9 Endometriosis; CRC cis rs860295 0.729 rs11264369 chr1:155359830 T/C cg02153340 chr1:155202674 NA 0.5 6.39 0.33 5.76e-10 Body mass index; CRC cis rs34779708 0.733 rs4934740 chr10:35547141 C/T cg03585969 chr10:35415529 CREM 0.52 6.79 0.35 5.37e-11 Inflammatory bowel disease;Crohn's disease; CRC cis rs951366 0.903 rs708723 chr1:205739266 C/T cg07167872 chr1:205819463 PM20D1 0.47 6.94 0.36 2.04e-11 Menarche (age at onset); CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg27449864 chr7:73133982 STX1A 0.39 6.44 0.33 4.21e-10 Obesity-related traits; CRC cis rs9733 0.596 rs6587516 chr1:150623221 C/T cg15448220 chr1:150897856 SETDB1 0.45 6.43 0.33 4.42e-10 Tonsillectomy; CRC trans rs7726839 0.540 rs55929359 chr5:595956 C/G cg25482853 chr8:67687455 SGK3 1.09 12.73 0.57 1.83e-30 Obesity-related traits; CRC cis rs589448 0.538 rs622656 chr12:69753595 C/T cg20891283 chr12:69753455 YEATS4 0.72 10.14 0.49 3.45e-21 Cerebrospinal fluid biomarker levels; CRC cis rs12477438 0.765 rs7605218 chr2:99593080 G/T cg26064155 chr2:99771622 LIPT1;TSGA10 -0.63 -8.58 -0.43 3.89e-16 Chronic sinus infection; CRC cis rs4285028 0.699 rs73855465 chr3:121574219 C/T cg20356878 chr3:121714668 ILDR1 -0.49 -6.86 -0.35 3.39e-11 Multiple sclerosis; CRC cis rs1499614 1.000 rs2141924 chr7:66186246 C/T cg12463550 chr7:65579703 CRCP 0.63 5.72 0.3 2.42e-8 Gout; CRC cis rs10504229 0.728 rs17215753 chr8:58153764 A/G cg21724239 chr8:58056113 NA 0.62 8.38 0.42 1.51e-15 Developmental language disorder (linguistic errors); CRC cis rs7572644 0.640 rs12464988 chr2:28058226 C/T cg27432699 chr2:27873401 GPN1 0.45 6.11 0.32 2.79e-9 Response to carboplatin and paclitaxel in ovarian cancer (Caspase 3/7 EC50); CRC cis rs2839186 0.771 rs2839155 chr21:47639992 A/G cg26721908 chr21:47610096 LSS -0.39 -5.99 -0.31 5.47e-9 Testicular germ cell tumor; CRC cis rs17767392 0.645 rs72726657 chr14:71669966 G/A cg13720639 chr14:72061746 SIPA1L1 -0.51 -6.01 -0.31 4.92e-9 Mitral valve prolapse; CRC cis rs3820068 0.603 rs7529759 chr1:15977877 A/G cg27534772 chr1:16042836 PLEKHM2 0.55 10.69 0.51 4.19e-23 Systolic blood pressure; CRC cis rs853679 0.517 rs1904841 chr6:28108085 C/T cg23161317 chr6:28129485 ZNF389 0.53 6.53 0.34 2.46e-10 Depression; CRC cis rs9393692 0.572 rs4145878 chr6:26198046 A/T cg13736514 chr6:26305472 NA -0.49 -8.47 -0.42 8.31e-16 Educational attainment; CRC cis rs9660180 0.967 rs12044597 chr1:1708801 A/G cg03396347 chr1:1875803 NA -0.6 -9.37 -0.46 1.23e-18 Body mass index; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg06925236 chr11:68039653 C11orf24 0.42 6.04 0.32 4.14e-9 Response to antipsychotic treatment; CRC cis rs854765 0.647 rs854769 chr17:18019011 A/G cg19630374 chr17:18023558 MYO15A 0.38 6.24 0.33 1.32e-9 Total body bone mineral density; CRC cis rs2204008 0.537 rs28680519 chr12:38502946 C/T cg26384229 chr12:38710491 ALG10B 0.65 8.76 0.43 1.06e-16 Bladder cancer; CRC cis rs9487051 0.735 rs351756 chr6:109538773 A/G cg21918786 chr6:109611834 NA 0.37 6.5 0.34 2.95e-10 Reticulocyte fraction of red cells; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg10893370 chr17:30228961 UTP6 0.46 6.04 0.32 4.09e-9 Thyroid stimulating hormone; CRC cis rs11724804 0.532 rs62297079 chr4:879977 G/A cg08222618 chr4:941054 TMEM175 0.72 12.65 0.57 3.74e-30 Primary biliary cholangitis;Limited cutaneous systemic scleroderma; CRC cis rs10207060 1.000 rs10207060 chr2:240687289 A/C cg20333904 chr2:240724165 NA -0.33 -6.6 -0.34 1.64e-10 Obesity-related traits; CRC cis rs1832871 0.711 rs9459769 chr6:158666493 T/C cg07165851 chr6:158734300 TULP4 0.6 7.53 0.38 4.9e-13 Height; CRC cis rs2243480 0.803 rs13224048 chr7:65993766 G/A cg18252515 chr7:66147081 NA -1.29 -15.47 -0.65 6.16e-41 Diabetic kidney disease; CRC cis rs2404602 1.000 rs12594541 chr15:76834368 G/A cg23625390 chr15:77176239 SCAPER 0.59 9.14 0.45 6.57e-18 Blood metabolite levels; CRC cis rs11098499 0.955 rs11944880 chr4:120159334 A/G cg24375607 chr4:120327624 NA -0.41 -6.23 -0.33 1.39e-9 Corneal astigmatism; CRC cis rs875971 1.000 rs12533997 chr7:65965377 A/G cg12463550 chr7:65579703 CRCP 0.47 6.79 0.35 5.17e-11 Aortic root size; CRC cis rs6860806 0.507 rs270606 chr5:131650867 A/G cg12564285 chr5:131593104 PDLIM4 0.48 8.03 0.4 1.78e-14 Breast cancer; CRC cis rs832540 0.830 rs252907 chr5:56120646 G/A cg18230493 chr5:56204884 C5orf35 -0.4 -5.97 -0.31 6.31e-9 Coronary artery disease; CRC cis rs1552244 1.000 rs7648104 chr3:10073311 C/A cg08888203 chr3:10149979 C3orf24 0.73 10.08 0.49 5.45e-21 Alzheimer's disease; CRC cis rs13108904 0.517 rs13134568 chr4:1334289 G/A cg23123621 chr4:1343375 KIAA1530 0.35 5.65 0.3 3.47e-8 Obesity-related traits; CRC cis rs2228479 0.717 rs34027607 chr16:89808939 T/C cg19635926 chr16:89946313 TCF25 0.57 5.96 0.31 6.58e-9 Skin colour saturation; CRC cis rs3820068 0.581 rs16851876 chr1:15950628 A/T cg27534772 chr1:16042836 PLEKHM2 -0.53 -10.43 -0.5 3.49e-22 Systolic blood pressure; CRC cis rs9660180 0.967 rs9660106 chr1:1797947 A/G cg03396347 chr1:1875803 NA -0.63 -9.83 -0.48 3.71e-20 Body mass index; CRC cis rs875971 0.825 rs6951503 chr7:65718936 T/G cg18876405 chr7:65276391 NA -0.52 -8.27 -0.41 3.3e-15 Aortic root size; CRC cis rs10089 1.000 rs10478796 chr5:127436187 A/G cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.73 10.23 0.49 1.7e-21 Ileal carcinoids; CRC cis rs6701037 0.748 rs11585368 chr1:175135448 G/A cg00321850 chr1:175162397 KIAA0040 -0.42 -6.83 -0.35 4.02e-11 Alcohol dependence; CRC cis rs7586879 0.593 rs10198356 chr2:25130592 A/G cg22495460 chr2:25135724 ADCY3 -0.88 -17.78 -0.7 5.01e-50 Body mass index; CRC cis rs894734 0.535 rs7301643 chr12:54325796 G/T cg17410650 chr12:54324560 NA -0.48 -9.14 -0.45 6.6e-18 Adverse response to chemotherapy (neutropenia/leucopenia) (all antimetabolite drugs); CRC cis rs4563143 0.514 rs73030738 chr19:29312328 G/A cg12756686 chr19:29218302 NA 0.62 8.47 0.42 8.45e-16 Methadone dose in opioid dependence; CRC trans rs1005277 0.579 rs2505257 chr10:38372664 A/G cg27523141 chr10:43048294 ZNF37B 0.49 7.1 0.36 7.95e-12 Extrinsic epigenetic age acceleration; CRC cis rs4285028 0.948 rs71329246 chr3:121680170 T/C cg11130432 chr3:121712080 ILDR1 -0.5 -6.61 -0.34 1.54e-10 Multiple sclerosis; CRC cis rs6534441 0.727 rs17831051 chr4:125440118 C/T cg21609808 chr4:125404261 NA 0.39 5.63 0.3 3.77e-8 Major depressive disorder; CRC cis rs4243830 0.850 rs2274553 chr1:6586553 C/T cg22792644 chr1:6614718 TAS1R1;NOL9 -0.69 -8.69 -0.43 1.7e-16 Body mass index; CRC cis rs1448094 0.511 rs10506920 chr12:86165212 A/T cg02569458 chr12:86230093 RASSF9 0.46 7.46 0.38 7.87e-13 Major depressive disorder; CRC cis rs10876993 0.890 rs115106209 chr12:58059331 G/A cg15848620 chr12:58087721 OS9 -0.66 -9.25 -0.45 2.85e-18 Celiac disease or Rheumatoid arthritis; CRC cis rs523522 0.962 rs55848094 chr12:120966659 G/A cg12219531 chr12:120966889 COQ5 0.69 9.28 0.46 2.36e-18 High light scatter reticulocyte count; CRC cis rs96067 0.805 rs11263860 chr1:36601368 C/G cg25304816 chr1:36627734 MAP7D1 0.42 6.03 0.32 4.42e-9 Corneal structure; CRC cis rs10504229 0.610 rs7840469 chr8:58146992 C/T cg05313129 chr8:58192883 C8orf71 -0.39 -5.82 -0.31 1.38e-8 Developmental language disorder (linguistic errors); CRC cis rs6964587 0.610 rs6950682 chr7:91464218 G/T cg17063962 chr7:91808500 NA 0.57 8.83 0.44 6.34e-17 Breast cancer; CRC cis rs453301 0.624 rs6987558 chr8:8862521 C/G cg11995313 chr8:8860691 ERI1 -0.39 -5.97 -0.31 6.1e-9 Joint mobility (Beighton score); CRC cis rs28386778 0.897 rs1062788 chr17:61896127 C/G cg25654072 chr17:61904446 PSMC5;FTSJ3 0.72 11.25 0.53 4.67e-25 Prudent dietary pattern; CRC cis rs929354 0.772 rs1182442 chr7:157026633 G/A cg05182265 chr7:156933206 UBE3C 0.76 14.55 0.63 2.33e-37 Body mass index; CRC cis rs7412746 0.611 rs752376 chr1:150941381 C/T cg17724175 chr1:150552817 MCL1 0.41 6.35 0.33 7.19e-10 Melanoma; CRC cis rs59698941 0.843 rs61541414 chr5:132226106 G/A cg14825688 chr5:132208181 LEAP2 -0.48 -5.61 -0.3 4.24e-8 Apolipoprotein A-IV levels; CRC cis rs4268898 0.722 rs11691212 chr2:24404733 A/G cg26838691 chr2:24397539 C2orf84 0.41 5.76 0.3 1.9e-8 Asthma; CRC cis rs2243480 0.764 rs2460423 chr7:65601216 A/T cg25985355 chr7:65971099 NA -0.52 -6.01 -0.31 5.03e-9 Diabetic kidney disease; CRC cis rs7131987 0.650 rs10843384 chr12:29472409 C/T cg09582351 chr12:29534625 ERGIC2 -0.34 -7.19 -0.37 4.36e-12 QT interval; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg11227645 chr1:224544764 CNIH4 0.4 6.1 0.32 3.02e-9 Intelligence (multi-trait analysis); CRC cis rs12477438 0.501 rs12613624 chr2:99732741 A/G cg26064155 chr2:99771622 LIPT1;TSGA10 -0.79 -13.29 -0.59 1.44e-32 Chronic sinus infection; CRC cis rs11758351 0.518 rs78871852 chr6:26221566 A/T cg10723962 chr6:26240782 HIST1H4F -0.38 -6.22 -0.32 1.54e-9 Gout;Renal underexcretion gout; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg04396637 chr12:51477072 CSRNP2 0.39 6.18 0.32 1.85e-9 Liver disease severity in Alagille syndrome; CRC cis rs2952156 0.920 rs903502 chr17:37829604 C/T cg00129232 chr17:37814104 STARD3 -0.7 -12.16 -0.56 2.34e-28 Asthma; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg23838375 chr17:72732946 RAB37 -0.44 -6.81 -0.35 4.51e-11 Myopia (pathological); CRC cis rs1862618 0.853 rs2548665 chr5:56131805 T/A cg20203395 chr5:56204925 C5orf35 -0.71 -8.56 -0.43 4.27e-16 Initial pursuit acceleration; CRC cis rs2386661 0.547 rs11259540 chr10:5646706 A/T cg17085576 chr10:5658249 NA -0.43 -6.22 -0.32 1.53e-9 Breast cancer; CRC cis rs67478160 0.643 rs1535098 chr14:104216513 T/A cg01849466 chr14:104193079 ZFYVE21 -0.49 -8.76 -0.43 1.04e-16 Schizophrenia; CRC cis rs7781266 0.847 rs2971970 chr7:133643778 T/G cg03336402 chr7:133662267 EXOC4 -0.6 -7.35 -0.38 1.62e-12 Educational attainment (college completion); CRC cis rs3796619 1.000 rs2290409 chr4:1067249 C/T cg11579758 chr4:1086637 RNF212 -0.41 -6.67 -0.35 1.1e-10 Recombination rate (males); CRC cis rs4975709 0.589 rs1466606 chr5:1865055 C/T cg14773178 chr5:1868261 NA 0.33 5.73 0.3 2.27e-8 Cardiovascular disease risk factors; CRC cis rs56235845 0.694 rs36102285 chr5:176774018 C/T cg17509989 chr5:176798049 RGS14 0.62 10.31 0.49 9.01e-22 Hemoglobin concentration;Hematocrit; CRC cis rs853679 0.517 rs4713148 chr6:28115921 G/A cg21251018 chr6:28226885 NKAPL 0.48 6.17 0.32 2.02e-9 Depression; CRC cis rs7677751 0.767 rs6832597 chr4:55076237 C/A cg17187183 chr4:55093834 PDGFRA 0.49 6.97 0.36 1.71e-11 Corneal astigmatism; CRC cis rs7917772 0.503 rs7904955 chr10:104367092 C/T cg22532475 chr10:104410764 TRIM8 -0.35 -6.42 -0.33 4.74e-10 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC cis rs274567 0.501 rs272855 chr5:131687175 C/T cg18301423 chr5:131593218 PDLIM4 0.39 6.28 0.33 1.09e-9 Blood metabolite levels; CRC cis rs853679 0.760 rs9295768 chr6:28209102 G/A cg03623178 chr6:28175578 NA 0.74 7.82 0.4 7.43e-14 Depression; CRC cis rs9926296 0.712 rs258332 chr16:89727683 G/A cg03605463 chr16:89740564 NA 0.59 9.15 0.45 6.28e-18 Vitiligo; CRC cis rs79349575 0.783 rs12603969 chr17:47034419 A/G cg22482690 chr17:47019901 SNF8 0.5 8.19 0.41 5.69e-15 Type 2 diabetes; CRC cis rs7385804 0.761 rs504141 chr7:100309125 G/A cg16850897 chr7:100343110 ZAN 0.45 6.87 0.35 3.22e-11 Iron status biomarkers;Mean corpuscular hemoglobin;Hematocrit;Iron status biomarkers (transferrin saturation);Red blood cell count;Iron status biomarkers (iron levels);Mean corpuscular volume;Hematological parameters; CRC cis rs1182196 0.533 rs2527521 chr7:2904928 A/G cg19717773 chr7:2847554 GNA12 0.42 7.34 0.38 1.68e-12 Plateletcrit; CRC cis rs4862750 0.914 rs6837117 chr4:187872379 C/T cg27532560 chr4:187881888 NA -0.56 -10.2 -0.49 2.05e-21 Lobe attachment (rater-scored or self-reported); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg07181902 chr2:85829892 TMEM150A 0.44 7.29 0.37 2.26e-12 Liver disease severity in Alagille syndrome; CRC cis rs736408 0.634 rs11717836 chr3:52807736 A/G cg08222913 chr3:52553049 STAB1 -0.34 -5.96 -0.31 6.64e-9 Bipolar disorder; CRC cis rs7715806 0.500 rs72633982 chr5:75001321 C/T cg19683494 chr5:74908142 NA 0.53 5.87 0.31 1.07e-8 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs916888 0.821 rs199505 chr17:44859410 A/G cg01570182 chr17:44337453 NA -1.07 -12.8 -0.58 9.93e-31 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC trans rs12458462 0.892 rs58675823 chr18:77463672 G/A cg09220050 chr20:48770642 TMEM189;TMEM189-UBE2V1 -0.46 -6.61 -0.34 1.59e-10 Monocyte count; CRC cis rs4332037 0.707 rs11763813 chr7:1896690 C/T cg21155852 chr7:2048760 MAD1L1 -0.47 -6.43 -0.33 4.38e-10 Bipolar disorder; CRC cis rs9322193 0.887 rs3734295 chr6:149915053 C/T cg05861140 chr6:150128134 PCMT1 -0.37 -5.85 -0.31 1.21e-8 Lung cancer; CRC cis rs9911578 1.000 rs12940681 chr17:56933622 T/C cg12560992 chr17:57184187 TRIM37 0.92 16.99 0.68 6.63e-47 Intelligence (multi-trait analysis); CRC cis rs7827545 0.644 rs4909452 chr8:135521053 C/G cg09855544 chr8:135498122 ZFAT -0.42 -5.65 -0.3 3.41e-8 Hypertension (SNP x SNP interaction); CRC cis rs1003719 0.715 rs1981432 chr21:38541356 G/A cg10648535 chr21:38446584 PIGP;TTC3 -0.49 -6.93 -0.36 2.17e-11 Eye color traits; CRC cis rs7124681 0.565 rs2203712 chr11:47534964 T/C cg20307385 chr11:47447363 PSMC3 0.53 7.9 0.4 4.27e-14 Body mass index (joint analysis main effects and physical activity interaction);Body mass index;Body mass index in physically active individuals; CRC cis rs910316 1.000 rs10142626 chr14:75555636 A/T cg08847533 chr14:75593920 NEK9 0.95 18.79 0.72 5e-54 Height; CRC cis rs8177253 0.898 rs8177258 chr3:133480387 C/A cg01448562 chr3:133502909 NA -0.53 -9.09 -0.45 9.35e-18 Iron status biomarkers; CRC cis rs7666738 0.830 rs6846229 chr4:99016546 C/T cg05340658 chr4:99064831 C4orf37 0.61 9.48 0.46 5.18e-19 Colonoscopy-negative controls vs population controls; CRC cis rs12188164 0.515 rs11744936 chr5:412112 C/T cg26850624 chr5:429559 AHRR -0.69 -10.63 -0.51 6.89e-23 Cystic fibrosis severity; CRC trans rs3807766 0.581 rs6954104 chr7:77693258 C/T cg14804635 chr15:75747750 SIN3A -0.47 -6.55 -0.34 2.18e-10 3-hydroxypropylmercapturic acid levels in smokers; CRC cis rs939658 0.805 rs8036435 chr15:79420031 T/C cg17916960 chr15:79447300 NA -0.44 -7.25 -0.37 2.97e-12 Refractive error; CRC cis rs75920871 0.588 rs721783 chr11:116907449 C/T cg20608306 chr11:116969690 SIK3 -0.31 -5.81 -0.31 1.47e-8 Subjective well-being; CRC cis rs910187 0.678 rs3818009 chr20:45816514 C/T cg27589058 chr20:45804311 EYA2 -0.37 -7.25 -0.37 3.03e-12 Migraine; CRC cis rs2976388 0.578 rs13254358 chr8:143823876 G/A cg24634471 chr8:143751801 JRK -0.49 -6.76 -0.35 6.45e-11 Urinary tract infection frequency; CRC cis rs501120 0.810 rs684196 chr10:44745950 A/T cg09554077 chr10:44749378 NA 0.9 13.3 0.59 1.4e-32 Coronary artery disease;Coronary heart disease; CRC trans rs1728785 1.000 rs1170429 chr16:68604126 A/G cg04657470 chr2:198365150 HSPE1;HSPD1 0.59 7.14 0.37 6.11e-12 Ulcerative colitis; CRC cis rs1799949 1.000 rs4793215 chr17:41318932 G/A cg01879757 chr17:41196368 BRCA1 -0.42 -6.25 -0.33 1.29e-9 Menopause (age at onset); CRC cis rs2952156 1.000 rs2643194 chr17:37853048 C/T cg20243544 chr17:37824526 PNMT 0.57 8.55 0.43 4.78e-16 Asthma; CRC cis rs4713118 0.621 rs9295756 chr6:28033396 G/T cg03623178 chr6:28175578 NA 0.9 11.84 0.55 3.65e-27 Parkinson's disease; CRC cis rs2688482 0.512 rs3103953 chr3:195520597 G/A cg11598736 chr3:195384522 SDHAP2 -0.62 -6.22 -0.32 1.5e-9 Lung disease severity in cystic fibrosis; CRC cis rs875971 0.862 rs2420173 chr7:65645399 A/T cg18876405 chr7:65276391 NA -0.53 -8.85 -0.44 5.57e-17 Aortic root size; CRC cis rs3820928 1.000 rs1346618 chr2:227771988 C/T cg11843606 chr2:227700838 RHBDD1 0.41 5.94 0.31 7.44e-9 Pulmonary function; CRC trans rs7395662 0.929 rs7946248 chr11:48613516 T/A cg21153622 chr11:89784906 NA -0.45 -7.22 -0.37 3.57e-12 HDL cholesterol; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg19324791 chr9:131182496 CERCAM 0.43 5.99 0.31 5.59e-9 Anxiety disorder; CRC cis rs1018836 0.923 rs4735230 chr8:91574184 G/C cg16814680 chr8:91681699 NA -0.74 -11.82 -0.55 4.12e-27 Ejection fraction in Tripanosoma cruzi seropositivity; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg21872391 chr10:112064057 SMNDC1 0.46 6.0 0.31 5.3300000000000004e-09 Thyroid stimulating hormone; CRC cis rs9733 0.650 rs1971378 chr1:150597261 C/T cg17724175 chr1:150552817 MCL1 -0.5 -7.93 -0.4 3.36e-14 Tonsillectomy; CRC cis rs4665809 0.590 rs1865324 chr2:26417533 C/A cg25036284 chr2:26402008 FAM59B -0.6 -7.65 -0.39 2.29e-13 Gut microbiome composition (summer); CRC cis rs2797160 0.935 rs60515555 chr6:126000638 T/G cg05901451 chr6:126070800 HEY2 -0.38 -5.93 -0.31 7.46e-9 Endometrial cancer; CRC cis rs812925 0.855 rs6545851 chr2:61498357 G/T cg10580144 chr2:61372316 C2orf74 -0.33 -6.49 -0.34 3.16e-10 Immature fraction of reticulocytes; CRC cis rs7677751 0.806 rs6836215 chr4:55102741 T/C cg17187183 chr4:55093834 PDGFRA 0.51 7.49 0.38 6.2800000000000005e-13 Corneal astigmatism; CRC trans rs1814175 0.587 rs7948538 chr11:50021353 A/C cg11707556 chr5:10655725 ANKRD33B -0.51 -9.92 -0.48 1.84e-20 Height; CRC cis rs950169 0.922 rs4842939 chr15:84827966 C/T cg17507749 chr15:85114479 UBE2QP1 -0.77 -11.24 -0.53 5e-25 Schizophrenia; CRC cis rs1552244 0.816 rs9847657 chr3:10173492 G/T cg00166722 chr3:10149974 C3orf24 0.53 7.42 0.38 9.82e-13 Alzheimer's disease; CRC cis rs7107174 1.000 rs10793304 chr11:78064907 A/G cg02023728 chr11:77925099 USP35 0.48 8.13 0.41 8.75e-15 Testicular germ cell tumor; CRC cis rs10751667 0.643 rs7396767 chr11:938808 G/A cg06064525 chr11:970664 AP2A2 -0.33 -6.71 -0.35 8.44e-11 Alzheimer's disease (late onset); CRC trans rs2048656 0.635 rs7830613 chr8:9649769 A/G cg08975724 chr8:8085496 FLJ10661 -0.46 -6.68 -0.35 9.98e-11 Schizophrenia; CRC cis rs870825 0.616 rs28463742 chr4:185611005 G/A cg04058563 chr4:185651563 MLF1IP 0.7 8.86 0.44 5.16e-17 Blood protein levels; CRC cis rs6496667 0.642 rs60597654 chr15:91066771 C/G cg04176472 chr15:90893244 GABARAPL3 0.49 7.2 0.37 4.19e-12 Rheumatoid arthritis; CRC cis rs7178572 0.568 rs12914345 chr15:77670401 A/C cg22256960 chr15:77711686 NA -0.69 -9.85 -0.48 3.11e-20 Type 2 diabetes; CRC cis rs2949837 0.581 rs2960436 chr7:45977282 G/A cg10677697 chr7:45961126 IGFBP3 0.36 6.3 0.33 9.38e-10 Sitting height ratio; CRC cis rs4853012 0.775 rs12465641 chr2:74337715 A/G cg20891558 chr2:74357851 NA -0.61 -9.42 -0.46 8.37e-19 Gestational age at birth (maternal effect); CRC cis rs10504229 0.683 rs903702 chr8:58128557 T/C cg04204079 chr8:58130323 NA -0.45 -5.78 -0.3 1.71e-8 Developmental language disorder (linguistic errors); CRC cis rs11997175 0.624 rs17778980 chr8:33700926 T/C ch.8.33884649F chr8:33765107 NA 0.46 6.68 0.35 1.01e-10 Body mass index; CRC cis rs9303401 0.573 rs34717648 chr17:56886624 T/A cg02118635 chr17:56770003 RAD51C;TEX14 0.77 9.9 0.48 2.12e-20 Cognitive test performance; CRC cis rs9894429 0.646 rs8079963 chr17:79603285 C/T cg09655341 chr17:79618100 PDE6G -0.36 -6.15 -0.32 2.2e-9 Eye color traits; CRC trans rs746265 0.818 rs57115092 chr15:39590048 A/G cg00573857 chr5:981189 NA -0.28 -5.96 -0.31 6.5e-9 PR interval; CRC cis rs4321325 0.733 rs13389505 chr2:127934888 T/C cg11380483 chr2:127933992 NA 0.63 8.28 0.42 3.18e-15 Protein C levels; CRC cis rs7487075 0.930 rs7308910 chr12:46838242 T/C cg17501823 chr12:47219793 SLC38A4 0.31 5.62 0.3 3.98e-8 Itch intensity from mosquito bite; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg25420398 chr3:133968920 RYK 0.46 7.38 0.38 1.31e-12 Liver disease severity in Alagille syndrome; CRC cis rs875971 0.545 rs1796222 chr7:66057154 T/C cg03233332 chr7:66118400 NA 0.43 5.86 0.31 1.14e-8 Aortic root size; CRC cis rs12927205 0.510 rs7185601 chr16:72035082 A/G cg14768367 chr16:72042858 DHODH 0.77 7.03 0.36 1.23e-11 Cholesterol, total;LDL cholesterol; CRC cis rs1215050 0.740 rs700740 chr4:98976003 A/C cg05340658 chr4:99064831 C4orf37 -0.48 -7.26 -0.37 2.75e-12 Waist-to-hip ratio adjusted for body mass index; CRC cis rs2075371 0.966 rs1901204 chr7:133985896 A/G cg20476274 chr7:133979776 SLC35B4 0.77 13.83 0.61 1.27e-34 Mean platelet volume; CRC cis rs2836974 0.932 rs2836953 chr21:40617483 G/A cg11890956 chr21:40555474 PSMG1 1.11 20.86 0.75 3.73e-62 Cognitive function; CRC cis rs55675132 0.510 rs17544384 chr1:115295160 T/C cg12756093 chr1:115239321 AMPD1 0.52 6.24 0.33 1.34e-9 Schizophrenia; CRC cis rs2274273 0.662 rs67215571 chr14:55673723 G/A cg10130446 chr14:55658398 DLGAP5 -0.43 -5.81 -0.31 1.46e-8 Protein biomarker; CRC cis rs1451375 0.583 rs3807556 chr7:50610536 G/A cg14593290 chr7:50529359 DDC 0.64 8.15 0.41 7.89e-15 Malaria; CRC cis rs3018066 0.666 rs7657975 chr4:107031691 G/C cg01869342 chr4:106983673 TBCK 0.46 6.01 0.31 4.84e-9 Cancer; CRC cis rs2066819 1.000 rs59295315 chr12:56708576 G/A cg26714650 chr12:56694279 CS -1.39 -11.42 -0.53 1.14e-25 Psoriasis vulgaris; CRC cis rs7927771 1.000 rs1317149 chr11:47486885 C/T cg05585544 chr11:47624801 NA -0.63 -11.33 -0.53 2.48e-25 Subjective well-being; CRC cis rs2440129 0.611 rs1126667 chr17:6902760 C/T cg03404566 chr17:6899310 ALOX12 -0.6 -10.64 -0.51 6.44e-23 Tonsillectomy; CRC cis rs10782582 0.593 rs11579752 chr1:76178694 C/T cg03433033 chr1:76189801 ACADM -0.41 -5.9 -0.31 9.04e-9 Daytime sleep phenotypes; CRC cis rs2811415 0.597 rs11720351 chr3:127751252 T/C cg13719885 chr3:127795394 NA -0.38 -5.79 -0.3 1.62e-8 Lung function (FEV1/FVC); CRC cis rs35146811 0.735 rs1138417 chr7:99807146 C/G cg00553149 chr7:99775558 STAG3;GPC2 -0.24 -5.63 -0.3 3.89e-8 Coronary artery disease; CRC cis rs4363385 0.934 rs1415964 chr1:152955085 T/C cg25856811 chr1:152973957 SPRR3 -0.22 -5.82 -0.31 1.43e-8 Inflammatory skin disease; CRC cis rs7615952 0.641 rs4490307 chr3:125712676 T/G cg18479299 chr3:125709523 NA -0.48 -6.14 -0.32 2.41e-9 Blood pressure (smoking interaction); CRC cis rs10779751 0.960 rs4845860 chr1:11324193 A/G cg08854313 chr1:11322531 MTOR 0.68 9.52 0.46 3.8e-19 Body mass index; CRC cis rs9611565 0.659 rs4822036 chr22:41936019 A/G cg17554472 chr22:41940697 POLR3H -0.55 -5.98 -0.31 5.91e-9 Vitiligo; CRC cis rs6088580 0.634 rs7271970 chr20:32987666 A/G cg24642439 chr20:33292090 TP53INP2 -0.38 -6.36 -0.33 6.76e-10 Glomerular filtration rate (creatinine); CRC cis rs4588572 0.688 rs2362829 chr5:77724036 T/A cg11547950 chr5:77652471 NA -0.49 -7.22 -0.37 3.57e-12 Triglycerides; CRC cis rs10089 1.000 rs4835941 chr5:127430905 C/T cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.73 10.23 0.49 1.7e-21 Ileal carcinoids; CRC cis rs4148883 0.645 rs2851287 chr4:100014548 G/A cg12011299 chr4:100065546 ADH4 0.53 11.79 0.55 5.28e-27 Alcohol dependence; CRC cis rs7772486 0.754 rs4360151 chr6:146255079 A/C cg23711669 chr6:146136114 FBXO30 -0.65 -11.14 -0.52 1.1e-24 Lobe attachment (rater-scored or self-reported); CRC cis rs1552244 1.000 rs68045038 chr3:10151828 A/G cg10729496 chr3:10149963 C3orf24 0.55 7.08 0.36 8.63e-12 Alzheimer's disease; CRC cis rs244731 0.959 rs6556307 chr5:176641434 C/T cg17509989 chr5:176798049 RGS14 0.62 8.34 0.42 2.01e-15 Urate levels in lean individuals; CRC trans rs67177172 0.521 rs1486285 chr5:84595711 G/C cg11637721 chr11:65486928 KAT5;RNASEH2C 0.36 5.98 0.31 5.95e-9 Photic sneeze reflex; CRC cis rs7659604 1.000 rs35249024 chr4:122664538 C/A cg20573242 chr4:122745356 CCNA2 0.41 6.15 0.32 2.26e-9 Type 2 diabetes; CRC cis rs7923609 1.000 rs4399232 chr10:64999490 C/T cg08743896 chr10:65200160 JMJD1C -0.39 -5.62 -0.3 4.15e-8 Educational attainment;Liver enzyme levels (alkaline phosphatase); CRC cis rs9937943 0.667 rs12919002 chr16:74612377 A/G cg01733217 chr16:74700730 RFWD3 0.75 8.35 0.42 1.98e-15 Neutrophil percentage of white cells; CRC cis rs2032447 0.736 rs115810 chr6:25975883 G/C cg17691542 chr6:26056736 HIST1H1C 0.42 5.73 0.3 2.32e-8 Intelligence (multi-trait analysis); CRC cis rs9517313 0.551 rs2274051 chr13:99091634 A/G cg20487152 chr13:99095054 FARP1 0.42 6.2 0.32 1.65e-9 Neuroticism; CRC cis rs9910055 0.529 rs400460 chr17:42182770 A/G cg10896456 chr17:42255109 ASB16;C17orf65 -0.36 -5.83 -0.31 1.32e-8 Total body bone mineral density; CRC cis rs9926296 0.656 rs2376881 chr16:89827011 C/G cg04287289 chr16:89883240 FANCA 0.53 8.15 0.41 7.87e-15 Vitiligo; CRC cis rs2840044 1.000 rs225259 chr17:33958168 A/G cg05299278 chr17:33885742 SLFN14 0.39 5.86 0.31 1.14e-8 Response to radiotherapy in cancer (late toxicity); CRC trans rs1455244 0.700 rs7229302 chr18:11508904 G/T cg08334199 chr2:178128998 NFE2L2 0.4 6.05 0.32 3.96e-9 Schizophrenia; CRC cis rs7677751 0.806 rs4864858 chr4:55089953 T/A cg13615338 chr4:55094005 PDGFRA 0.42 6.14 0.32 2.32e-9 Corneal astigmatism; CRC cis rs6964587 1.000 rs13245393 chr7:91641928 A/G cg17063962 chr7:91808500 NA 0.8 14.3 0.62 2.04e-36 Breast cancer; CRC cis rs1046896 0.561 rs8076476 chr17:80861017 A/C cg02711726 chr17:80685570 FN3KRP -0.51 -6.87 -0.35 3.32e-11 Glycated hemoglobin levels; CRC trans rs1814175 0.817 rs10839351 chr11:49758153 C/T cg21153622 chr11:89784906 NA -0.38 -6.09 -0.32 3.2e-9 Height; CRC cis rs28386778 0.897 rs2036911 chr17:61794839 A/T cg11494091 chr17:61959527 GH2 0.62 10.32 0.49 8.07e-22 Prudent dietary pattern; CRC cis rs4601790 0.601 rs66864335 chr11:65390803 G/A cg21033440 chr11:65409861 SIPA1 -0.65 -8.1 -0.41 1.1e-14 Blood pressure (age interaction); CRC cis rs4332037 0.906 rs62442903 chr7:1953416 G/A cg21155852 chr7:2048760 MAD1L1 -0.51 -6.91 -0.36 2.53e-11 Bipolar disorder; CRC cis rs875971 0.520 rs160645 chr7:65556307 A/G cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.62 -7.83 -0.4 6.78e-14 Aortic root size; CRC cis rs6951245 0.872 rs11768486 chr7:1101290 C/A cg21664854 chr7:1097933 C7orf50;GPR146 0.77 8.8 0.44 7.85e-17 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs7666738 0.791 rs60028147 chr4:99046618 G/A cg17366294 chr4:99064904 C4orf37 0.44 7.37 0.38 1.35e-12 Colonoscopy-negative controls vs population controls; CRC cis rs4700695 0.841 rs402100 chr5:65266125 A/G cg21114390 chr5:65439923 SFRS12 0.57 6.84 0.35 3.78e-11 Facial morphology (factor 19); CRC cis rs10504229 0.861 rs67042991 chr8:58191749 G/C cg22535103 chr8:58192502 C8orf71 -0.82 -12.27 -0.56 9.63e-29 Developmental language disorder (linguistic errors); CRC cis rs2032447 0.901 rs2213284 chr6:26031868 G/A cg18357526 chr6:26021779 HIST1H4A 0.79 12.06 0.55 5.67e-28 Intelligence (multi-trait analysis); CRC cis rs9787249 0.957 rs12086750 chr1:40210468 G/C cg01941586 chr1:40203715 PPIE -0.45 -6.29 -0.33 1.04e-9 Blood protein levels; CRC cis rs2836974 0.931 rs2776307 chr21:40713833 C/G cg11644478 chr21:40555479 PSMG1 -0.73 -10.65 -0.51 5.79e-23 Cognitive function; CRC cis rs9398803 0.830 rs1361109 chr6:126771143 C/T cg19875578 chr6:126661172 C6orf173 0.42 5.81 0.31 1.45e-8 Male-pattern baldness; CRC trans rs61931739 0.500 rs11053208 chr12:34460029 A/G cg26384229 chr12:38710491 ALG10B 0.59 8.52 0.43 5.67e-16 Morning vs. evening chronotype; CRC cis rs10540 1.000 rs12788729 chr11:502371 G/A cg03934478 chr11:495069 RNH1 0.69 7.77 0.39 9.92e-14 Body mass index; CRC cis rs4728302 0.869 rs10156088 chr7:133592544 G/A cg10665199 chr7:133106180 EXOC4 0.39 5.84 0.31 1.25e-8 Intelligence;Intelligence (multi-trait analysis); CRC cis rs7618915 0.570 rs11130319 chr3:52755592 A/T cg10802521 chr3:52805072 NEK4 -0.6 -9.1 -0.45 8.83e-18 Bipolar disorder; CRC cis rs8044868 0.586 rs7190994 chr16:72099241 T/A cg23815491 chr16:72088622 HP 0.5 7.33 0.37 1.83e-12 Body mass index (change over time) in cancer or chronic obstructive pulmonary disease;Body mass index (change over time) in cancer; CRC cis rs9733 0.526 rs6587542 chr1:150907701 G/T cg17724175 chr1:150552817 MCL1 0.4 6.14 0.32 2.37e-9 Tonsillectomy; CRC cis rs1045529 0.524 rs34251783 chr8:8891376 T/C cg14979609 chr8:8086686 FLJ10661 0.38 6.25 0.33 1.26e-9 Myopia;Myopia (pathological); CRC cis rs9487051 0.676 rs6568560 chr6:109592851 G/A cg12927641 chr6:109611667 NA -0.38 -6.74 -0.35 7.22e-11 Reticulocyte fraction of red cells; CRC cis rs561341 0.769 rs7217004 chr17:30178092 A/G cg12193833 chr17:30244370 NA 0.6 6.74 0.35 7.01e-11 Hip circumference adjusted for BMI; CRC cis rs1577917 0.917 rs12202170 chr6:86590386 A/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.59 -7.23 -0.37 3.36e-12 Response to antipsychotic treatment; CRC cis rs9488822 0.676 rs868943 chr6:116337503 G/A cg05304507 chr6:116381966 FRK 0.31 8.43 0.42 1.11e-15 Cholesterol, total;LDL cholesterol; CRC cis rs4409675 0.576 rs6660899 chr1:28214281 G/C cg23691781 chr1:28212827 C1orf38 0.33 7.55 0.38 4.28e-13 Corneal astigmatism; CRC cis rs977987 0.741 rs10514393 chr16:75344476 C/T cg03315344 chr16:75512273 CHST6 0.53 8.94 0.44 2.86e-17 Dupuytren's disease; CRC cis rs9911578 0.741 rs2611776 chr17:56819636 G/T cg05425664 chr17:57184151 TRIM37 -0.48 -7.51 -0.38 5.46e-13 Intelligence (multi-trait analysis); CRC cis rs225245 0.782 rs161183 chr17:33919475 G/C cg05299278 chr17:33885742 SLFN14 0.49 8.04 0.41 1.62e-14 Reticulocyte count;Reticulocyte fraction of red cells;High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells; CRC cis rs3820928 0.605 rs4675124 chr2:227802354 G/A cg11843606 chr2:227700838 RHBDD1 -0.47 -7.17 -0.37 4.91e-12 Pulmonary function; CRC cis rs1707322 1.000 rs6675222 chr1:46326576 G/T cg06784218 chr1:46089804 CCDC17 0.51 8.98 0.44 2.13e-17 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs11785400 0.793 rs1056012 chr8:143740167 A/G cg24634471 chr8:143751801 JRK 0.48 6.51 0.34 2.81e-10 Schizophrenia; CRC cis rs780096 0.526 rs2010087 chr2:27637235 C/T cg02592271 chr2:27665507 KRTCAP3 -0.26 -5.95 -0.31 6.71e-9 Total body bone mineral density; CRC cis rs1639906 0.965 rs1639908 chr7:2230644 C/G cg19897017 chr7:2163380 MAD1L1 -0.42 -6.61 -0.34 1.58e-10 Colonoscopy-negative controls vs population controls; CRC cis rs2576037 0.583 rs9304336 chr18:44461687 T/C cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.63 11.25 0.53 4.78e-25 Personality dimensions; CRC cis rs875971 0.830 rs427575 chr7:65519219 A/G cg05627663 chr7:65219948 SNORA22;CCT6P1 0.39 5.63 0.3 3.84e-8 Aortic root size; CRC cis rs939584 1.000 rs11127489 chr2:646081 C/T cg03610516 chr2:642275 NA 0.42 5.87 0.31 1.06e-8 Body mass index; CRC cis rs8180040 0.620 rs56217494 chr3:47048452 T/G cg27129171 chr3:47204927 SETD2 -0.71 -11.1 -0.52 1.52e-24 Colorectal cancer; CRC cis rs10486722 0.651 rs10951657 chr7:41781363 T/C cg22138096 chr7:41772439 LOC285954 0.49 6.28 0.33 1.07e-9 Pit-and-Fissure caries; CRC cis rs4727027 0.901 rs7794500 chr7:148819519 C/T cg23583168 chr7:148888333 NA 0.84 13.71 0.6 3.89e-34 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC cis rs10751667 0.666 rs10902243 chr11:949900 T/C cg23136738 chr11:925521 AP2A2 -0.41 -7.01 -0.36 1.32e-11 Alzheimer's disease (late onset); CRC cis rs1862618 0.853 rs11739344 chr5:56111087 A/C cg12311346 chr5:56204834 C5orf35 -0.8 -10.34 -0.5 6.98e-22 Initial pursuit acceleration; CRC trans rs8123881 0.733 rs7268466 chr20:15810676 C/T cg21403089 chr7:108166784 PNPLA8 0.51 6.15 0.32 2.22e-9 Body mass index; CRC cis rs10791097 0.967 rs10894268 chr11:130717153 C/T cg12179176 chr11:130786555 SNX19 0.56 8.22 0.41 4.67e-15 Autism spectrum disorder or schizophrenia;Schizophrenia; CRC cis rs6445967 1.000 rs6791748 chr3:58308519 G/A cg23715586 chr3:58305044 RPP14 0.36 6.02 0.31 4.67e-9 Platelet count; CRC cis rs897984 0.572 rs112906665 chr16:31040139 T/C cg02466173 chr16:30829666 NA -0.61 -9.14 -0.45 6.5e-18 Dementia with Lewy bodies; CRC cis rs10979 1.000 rs9390107 chr6:143892721 A/T cg25407410 chr6:143891975 LOC285740 -0.83 -13.54 -0.6 1.68e-33 Hypospadias; CRC cis rs694739 0.595 rs11606015 chr11:64136877 C/G cg02228329 chr11:64053129 BAD;GPR137 0.5 6.95 0.36 2.01e-11 Alopecia areata;Crohn's disease;Psoriasis vulgaris; CRC trans rs766903 1.000 rs4761832 chr12:51694278 C/T cg09910207 chr12:91452697 KERA 0.45 5.98 0.31 5.76e-9 Aging (time to death); CRC cis rs9372498 0.505 rs62424204 chr6:118861642 G/A cg07617317 chr6:118971624 C6orf204 0.5 6.17 0.32 2.01e-9 Diastolic blood pressure; CRC cis rs7584330 0.740 rs11891348 chr2:238440449 T/G cg16989719 chr2:238392110 NA -0.37 -6.49 -0.34 3.22e-10 Prostate cancer; CRC trans rs35110281 0.774 rs2838323 chr21:44999086 G/A cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.44 7.18 0.37 4.82e-12 Mean corpuscular volume; CRC cis rs3617 0.539 rs9880619 chr3:52953055 G/A cg15147215 chr3:52552868 STAB1 0.49 8.52 0.43 5.65e-16 Red blood cell count;Autism spectrum disorder or schizophrenia; CRC trans rs7267979 0.706 rs6138542 chr20:25207773 C/A cg17903999 chr18:56338584 MALT1 -0.4 -6.4 -0.33 5.46e-10 Liver enzyme levels (alkaline phosphatase); CRC cis rs2243480 1.000 rs781149 chr7:65481284 C/T cg18252515 chr7:66147081 NA -1.1 -12.3 -0.56 7.15e-29 Diabetic kidney disease; CRC cis rs875971 1.000 rs778696 chr7:65870813 C/G cg00343986 chr7:65444356 GUSB 0.43 6.3 0.33 9.66e-10 Aortic root size; CRC cis rs1448094 0.511 rs10506923 chr12:86152595 C/T cg02569458 chr12:86230093 RASSF9 -0.48 -7.92 -0.4 3.61e-14 Major depressive disorder; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg16638571 chr8:81083534 TPD52 0.47 6.61 0.34 1.59e-10 Anxiety disorder; CRC cis rs6495122 0.644 rs62029217 chr15:75261899 C/T cg05627522 chr15:75251581 NA 0.5 7.6 0.39 3.04e-13 Caffeine consumption;Diastolic blood pressure;Coffee consumption; CRC cis rs4972806 0.814 rs4246626 chr2:177046430 A/C cg25347419 chr2:177043501 NA 0.58 9.1 0.45 9.05e-18 IgG glycosylation; CRC trans rs17270561 0.887 rs717551 chr6:25855624 T/C cg21589273 chr3:113416452 KIAA2018 0.54 5.97 0.31 6.27e-9 Iron status biomarkers; CRC cis rs12760731 0.565 rs12047117 chr1:178132608 G/A cg00404053 chr1:178313656 RASAL2 1.02 10.74 0.51 2.82e-23 Obesity-related traits; CRC cis rs651907 0.557 rs2288272 chr3:101378476 C/T cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.62 8.34 0.42 2.12e-15 Colorectal cancer; CRC cis rs17601876 0.545 rs4775936 chr15:51536022 A/G cg19946085 chr15:51559439 CYP19A1 0.3 5.73 0.3 2.29e-8 Estrone/androstenedione ratio in resected early stage-receptor positive breast cancer; CRC cis rs11764590 0.715 rs9639202 chr7:2087315 G/A cg02421172 chr7:1938701 MAD1L1 0.46 6.09 0.32 3.18e-9 Neuroticism; CRC cis rs2404602 0.692 rs59088060 chr15:76859974 T/C cg23625390 chr15:77176239 SCAPER 0.47 6.85 0.35 3.61e-11 Blood metabolite levels; CRC cis rs10751667 0.643 rs11246344 chr11:933783 A/C cg23136738 chr11:925521 AP2A2 -0.41 -6.78 -0.35 5.53e-11 Alzheimer's disease (late onset); CRC cis rs56114371 0.530 rs9348774 chr6:27688930 C/T cg20933634 chr6:27740509 NA 0.55 7.13 0.37 6.29e-12 Breast cancer; CRC cis rs1387259 0.839 rs7486941 chr12:48578631 C/G cg15465823 chr12:48382534 COL2A1 -0.37 -6.14 -0.32 2.43e-9 Obstructive sleep apnea trait (apnea hypopnea index); CRC cis rs11190604 1.000 rs2489048 chr10:102348497 G/T cg16342193 chr10:102329863 NA -0.35 -5.71 -0.3 2.56e-8 Palmitoleic acid (16:1n-7) levels; CRC cis rs34779708 0.966 rs12761675 chr10:35438337 C/T cg03585969 chr10:35415529 CREM -0.61 -8.15 -0.41 7.47e-15 Inflammatory bowel disease;Crohn's disease; CRC cis rs2732480 0.500 rs11168468 chr12:48612465 C/T cg21466736 chr12:48725269 NA -0.53 -8.01 -0.4 1.96e-14 Hemoglobin concentration;Red blood cell count;Hematocrit; CRC cis rs73195822 0.527 rs73194059 chr12:111221740 G/A cg12870014 chr12:110450643 ANKRD13A 0.63 6.98 0.36 1.61e-11 Itch intensity from mosquito bite; CRC cis rs9527 0.830 rs11191440 chr10:104641511 G/A cg04362960 chr10:104952993 NT5C2 0.64 8.38 0.42 1.6e-15 Arsenic metabolism; CRC cis rs9814567 0.964 rs4974480 chr3:134178562 A/T cg06109529 chr3:134205091 CEP63;ANAPC13 -0.8 -11.69 -0.54 1.19e-26 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs1153858 0.945 rs7182300 chr15:45634928 G/A cg10760299 chr15:45669010 GATM 0.49 7.83 0.4 6.7e-14 Homoarginine levels; CRC cis rs7542091 0.666 rs7537070 chr1:210043565 A/G cg22029157 chr1:209979665 IRF6 0.47 7.4 0.38 1.11e-12 Monobrow; CRC trans rs2303319 0.504 rs12465734 chr2:162437859 A/G cg14875682 chr5:52083620 ITGA1;PELO -0.75 -6.01 -0.31 5.03e-9 Cognitive function; CRC cis rs73195822 0.506 rs61440260 chr12:111142855 G/T cg12870014 chr12:110450643 ANKRD13A 0.78 9.46 0.46 6.03e-19 Itch intensity from mosquito bite; CRC cis rs7487075 0.722 rs5016479 chr12:46712784 G/T cg22049899 chr12:47219821 SLC38A4 0.34 6.3 0.33 9.67e-10 Itch intensity from mosquito bite; CRC cis rs1799949 1.000 rs1960605 chr17:41305397 C/T cg01879757 chr17:41196368 BRCA1 -0.44 -6.73 -0.35 7.33e-11 Menopause (age at onset); CRC cis rs3820068 0.553 rs7545782 chr1:15955227 G/C cg13390004 chr1:15929781 NA 0.48 6.9 0.36 2.74e-11 Systolic blood pressure; CRC cis rs736801 0.836 rs2522052 chr5:131798487 C/T cg02033258 chr5:131593261 PDLIM4 -0.34 -6.07 -0.32 3.52e-9 Breast cancer;Mosquito bite size; CRC cis rs6665290 0.904 rs3795451 chr1:227181923 C/T cg10327440 chr1:227177885 CDC42BPA -1.04 -23.3 -0.79 1.34e-71 Myeloid white cell count; CRC cis rs832540 0.931 rs832399 chr5:56222358 A/T cg24531977 chr5:56204891 C5orf35 -0.49 -7.61 -0.39 2.86e-13 Coronary artery disease; CRC cis rs9443645 0.869 rs9361489 chr6:79816785 T/C cg05283184 chr6:79620031 NA -0.58 -9.01 -0.44 1.68e-17 Intelligence (multi-trait analysis); CRC cis rs10979 0.679 rs35914889 chr6:143886392 A/T cg25407410 chr6:143891975 LOC285740 -0.7 -9.84 -0.48 3.28e-20 Hypospadias; CRC cis rs13108904 0.967 rs62293658 chr4:1276416 T/C cg00684032 chr4:1343700 KIAA1530 -0.37 -5.69 -0.3 2.76e-8 Obesity-related traits; CRC cis rs473651 0.692 rs579511 chr2:239334914 C/G cg18131467 chr2:239335373 ASB1 0.98 20.7 0.75 1.52e-61 Multiple system atrophy; CRC trans rs6550704 0.687 rs9865314 chr3:22634337 A/G cg14591243 chr3:136471577 STAG1 -0.42 -6.1 -0.32 2.9e-9 Daytime sleep phenotypes; CRC cis rs11764590 0.585 rs11772463 chr7:2078132 A/C cg13880726 chr7:1868755 MAD1L1 -0.48 -5.81 -0.31 1.47e-8 Neuroticism; CRC cis rs2762353 0.779 rs6905614 chr6:25840485 G/T cg12310025 chr6:25882481 NA -0.46 -7.09 -0.36 8.3e-12 Blood metabolite levels; CRC cis rs57590327 0.504 rs13065281 chr3:81693550 G/A cg07356753 chr3:81810745 GBE1 -0.64 -8.29 -0.42 2.97e-15 Extraversion; CRC cis rs6938 0.534 rs12904897 chr15:75217686 A/G cg18612461 chr15:75251733 NA 0.39 6.16 0.32 2.09e-9 Breast cancer; CRC cis rs2032447 0.832 rs10425 chr6:26056549 A/G cg03517284 chr6:25882590 NA -0.47 -6.59 -0.34 1.74e-10 Intelligence (multi-trait analysis); CRC cis rs514406 0.661 rs550561 chr1:53375134 C/T cg27535305 chr1:53392650 SCP2 -0.44 -7.72 -0.39 1.44e-13 Monocyte count; CRC cis rs9322193 0.962 rs9393175 chr6:149998723 A/G cg13206674 chr6:150067644 NUP43 0.66 9.36 0.46 1.27e-18 Lung cancer; CRC cis rs7258465 0.965 rs10408290 chr19:18542701 C/T cg01065977 chr19:18549689 ISYNA1 -0.42 -6.27 -0.33 1.12e-9 Breast cancer; CRC cis rs2120019 1.000 rs12901243 chr15:75374233 C/T cg17294928 chr15:75287854 SCAMP5 -0.73 -10.92 -0.52 6.61e-24 Blood trace element (Zn levels); CRC cis rs35740288 0.929 rs11073537 chr15:86312681 G/A cg20737812 chr15:86336631 KLHL25 -0.37 -5.71 -0.3 2.54e-8 Eosinophil percentage of white cells;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes; CRC cis rs13118159 0.872 rs4974605 chr4:1346389 C/G cg20092199 chr4:1342459 KIAA1530 0.33 5.76 0.3 1.92e-8 Longevity; CRC cis rs9368481 0.569 rs6907403 chr6:26877297 A/C cg12292205 chr6:26970375 C6orf41 0.62 9.82 0.48 4e-20 Autism spectrum disorder or schizophrenia; CRC cis rs9814567 1.000 rs7371896 chr3:134249769 C/G cg06109529 chr3:134205091 CEP63;ANAPC13 -0.8 -12.15 -0.56 2.67e-28 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs823143 0.570 rs823082 chr1:205786935 C/T cg17178900 chr1:205818956 PM20D1 -0.57 -8.65 -0.43 2.23e-16 Monocyte percentage of white cells; CRC trans rs2303319 0.504 rs72877343 chr2:162607487 A/C cg10272801 chr16:14013773 ERCC4 -0.68 -6.07 -0.32 3.49e-9 Cognitive function; CRC cis rs78456975 1.000 rs6730391 chr2:1566838 A/C cg12573674 chr2:1569213 NA -0.73 -7.8 -0.39 8.35e-14 Placebo response in major depressive disorder (% change in symptom score); CRC cis rs875971 1.000 rs2420820 chr7:66091907 T/C cg11764359 chr7:65958608 NA -0.61 -9.45 -0.46 6.57e-19 Aortic root size; CRC cis rs9894429 1.000 rs11652797 chr17:79574124 A/G cg21984481 chr17:79567631 NPLOC4 -0.52 -9.63 -0.47 1.66e-19 Eye color traits; CRC cis rs10504073 0.584 rs10957356 chr8:49980634 G/A cg00325661 chr8:49890786 NA 0.58 10.41 0.5 3.9e-22 Blood metabolite ratios; CRC cis rs2976388 0.609 rs2263092 chr8:143789966 A/G cg12516270 chr8:143859308 LYNX1 0.44 7.93 0.4 3.55e-14 Urinary tract infection frequency; CRC cis rs9611565 0.659 rs28623192 chr22:41940524 A/G cg06634786 chr22:41940651 POLR3H -0.66 -7.74 -0.39 1.25e-13 Vitiligo; CRC cis rs7811142 1.000 rs2897358 chr7:100088640 C/G cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.09 15.2 0.64 6.92e-40 Platelet count; CRC cis rs2204008 0.539 rs1283295 chr12:38146014 A/C cg26384229 chr12:38710491 ALG10B -0.57 -8.34 -0.42 2.02e-15 Bladder cancer; CRC trans rs9329221 0.507 rs12678938 chr8:10016969 C/T cg16141378 chr3:129829833 LOC729375 0.42 6.37 0.33 6.27e-10 Neuroticism; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg18656577 chr17:8286464 RPL26 0.44 7.34 0.38 1.67e-12 Liver disease severity in Alagille syndrome; CRC cis rs7044106 0.791 rs2416798 chr9:123480603 C/T cg09586646 chr9:123605570 PSMD5;LOC253039 0.62 8.82 0.44 6.77e-17 Hip circumference adjusted for BMI; CRC cis rs514406 0.929 rs483073 chr1:53314084 T/C cg08859206 chr1:53392774 SCP2 -0.44 -7.01 -0.36 1.38e-11 Monocyte count; CRC cis rs10781543 0.839 rs4379550 chr9:139376426 C/T cg13856295 chr9:139396418 NOTCH1 0.37 5.7 0.3 2.65e-8 Monocyte percentage of white cells; CRC cis rs9469578 0.892 rs73743333 chr6:33714042 G/A cg18708504 chr6:33715942 IP6K3 0.66 7.56 0.38 4e-13 Phosphorus levels; CRC cis rs1448094 0.511 rs61930588 chr12:86158991 A/G cg25456477 chr12:86230367 RASSF9 0.39 6.56 0.34 2.13e-10 Major depressive disorder; CRC cis rs1949733 0.656 rs2688243 chr4:8436286 A/G cg11789530 chr4:8429930 ACOX3 0.71 10.51 0.5 1.79e-22 Response to antineoplastic agents; CRC cis rs4665809 0.590 rs4665321 chr2:26433801 A/C cg22920501 chr2:26401640 FAM59B -0.87 -12.36 -0.56 4.43e-29 Gut microbiome composition (summer); CRC cis rs1656402 1.000 rs1190438 chr2:233423259 G/T cg03852847 chr2:233439513 NA 0.45 7.71 0.39 1.54e-13 Non-small cell lung cancer (survival); CRC cis rs7552404 1.000 rs1498316 chr1:76159198 G/A cg22875332 chr1:76189707 ACADM 0.68 9.34 0.46 1.45e-18 Blood metabolite levels;Acylcarnitine levels; CRC cis rs10504229 0.683 rs35840293 chr8:58117634 C/T cg22535103 chr8:58192502 C8orf71 -0.7 -9.34 -0.46 1.47e-18 Developmental language disorder (linguistic errors); CRC cis rs2739330 0.828 rs4822454 chr22:24255208 G/A cg24846343 chr22:24311635 DDTL 0.82 14.72 0.63 5.05e-38 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs780096 0.526 rs780107 chr2:27684734 A/G cg12000995 chr2:27665139 KRTCAP3 -0.32 -6.67 -0.35 1.1e-10 Total body bone mineral density; CRC cis rs12701220 0.689 rs12536282 chr7:1115650 C/T cg26769984 chr7:1090371 C7orf50 0.53 6.78 0.35 5.62e-11 Bronchopulmonary dysplasia; CRC cis rs6762 0.642 rs28692469 chr11:839675 T/C cg03885332 chr11:832357 CD151 -0.42 -6.28 -0.33 1.05e-9 Mean platelet volume; CRC cis rs6456156 0.774 rs9347175 chr6:167527644 A/T cg19688584 chr6:167529678 CCR6 -0.33 -6.16 -0.32 2.16e-9 Primary biliary cholangitis; CRC cis rs1044826 0.642 rs7652860 chr3:139205818 T/A cg00490450 chr3:139108681 COPB2 0.44 6.58 0.34 1.83e-10 Obesity-related traits; CRC cis rs1862618 0.853 rs252898 chr5:56188931 T/C cg18230493 chr5:56204884 C5orf35 -0.76 -9.41 -0.46 9.04e-19 Initial pursuit acceleration; CRC cis rs11696845 0.626 rs4810439 chr20:43377870 C/G cg25301532 chr20:43378953 KCNK15 -0.4 -7.05 -0.36 1.07e-11 Obesity-related traits; CRC cis rs651907 0.535 rs13085776 chr3:101505507 A/G cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.54 6.73 0.35 7.51e-11 Colorectal cancer; CRC cis rs3857067 0.806 rs10212784 chr4:95101638 C/T cg11021082 chr4:95130006 SMARCAD1 -0.49 -7.65 -0.39 2.22e-13 QT interval; CRC cis rs2971970 0.519 rs62470447 chr7:133632339 C/T cg03336402 chr7:133662267 EXOC4 0.63 9.38 0.46 1.12e-18 Intelligence (multi-trait analysis); CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg01663232 chr2:214016940 IKZF2 -0.41 -6.07 -0.32 3.45e-9 Myopia (pathological); CRC cis rs6831352 0.959 rs6532796 chr4:100042242 C/T cg13256891 chr4:100009986 ADH5 -0.64 -9.09 -0.45 9.25e-18 Alcohol dependence; CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg19981660 chr12:132434166 EP400 0.41 6.63 0.34 1.4e-10 Obesity-related traits; CRC cis rs7119 0.717 rs12916973 chr15:77808099 C/T cg10437265 chr15:77819839 NA -0.66 -11.61 -0.54 2.41e-26 Type 2 diabetes; CRC cis rs2842992 0.915 rs2758321 chr6:160071611 C/G cg19482086 chr6:160211437 TCP1;MRPL18 0.68 8.62 0.43 2.88e-16 Age-related macular degeneration (geographic atrophy); CRC cis rs1218582 0.772 rs10908448 chr1:154882544 A/G cg03351412 chr1:154909251 PMVK -0.54 -8.68 -0.43 1.84e-16 Prostate cancer; CRC cis rs7119 0.717 rs12902912 chr15:77809170 A/G cg10437265 chr15:77819839 NA 0.7 12.86 0.58 5.83e-31 Type 2 diabetes; CRC cis rs921968 0.643 rs526134 chr2:219402371 G/A cg02176678 chr2:219576539 TTLL4 0.48 7.98 0.4 2.45e-14 Mean corpuscular hemoglobin concentration; CRC cis rs3106136 0.967 rs11097411 chr4:95222626 C/T cg11021082 chr4:95130006 SMARCAD1 -0.47 -7.3 -0.37 2.24e-12 Capecitabine sensitivity; CRC cis rs7772486 0.686 rs2092263 chr6:146029687 G/A cg23711669 chr6:146136114 FBXO30 -0.65 -10.71 -0.51 3.62e-23 Lobe attachment (rater-scored or self-reported); CRC cis rs6951245 0.872 rs77569514 chr7:1085508 G/A cg24642844 chr7:1081250 C7orf50 -0.79 -9.4 -0.46 9.42e-19 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs5758511 0.679 rs55867855 chr22:42623258 G/A cg00645731 chr22:42541494 CYP2D7P1 0.66 10.36 0.5 6.08e-22 Birth weight; CRC cis rs2836974 0.897 rs3945 chr21:40566067 A/G cg11644478 chr21:40555479 PSMG1 0.72 10.33 0.49 7.58e-22 Cognitive function; CRC cis rs736801 0.780 rs11951091 chr5:131786595 G/A cg02033258 chr5:131593261 PDLIM4 0.32 5.66 0.3 3.31e-8 Breast cancer;Mosquito bite size; CRC cis rs2179367 0.959 rs564961 chr6:149657227 G/A cg07828024 chr6:149772892 ZC3H12D -0.37 -5.99 -0.31 5.48e-9 Dupuytren's disease; CRC cis rs6543140 1.000 rs6543140 chr2:103074274 G/T cg03938978 chr2:103052716 IL18RAP 0.41 6.54 0.34 2.37e-10 Blood protein levels; CRC cis rs6502050 0.805 rs6502057 chr17:80082060 A/G cg09264619 chr17:80180166 NA 0.36 5.86 0.31 1.12e-8 Life satisfaction; CRC cis rs8072100 0.967 rs11656855 chr17:45714655 C/T cg08085267 chr17:45401833 C17orf57 0.6 9.65 0.47 1.45e-19 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs6076065 0.723 rs743023 chr20:23400852 T/C cg11657817 chr20:23433608 CST11 0.45 6.49 0.34 3.17e-10 Facial morphology (factor 15, philtrum width); CRC cis rs524281 0.861 rs2177053 chr11:65966145 A/C cg14036092 chr11:66035641 RAB1B -0.48 -5.77 -0.3 1.79e-8 Electroencephalogram traits; CRC cis rs2795502 1.000 rs3121279 chr10:43378449 T/A cg27426351 chr10:43362370 NA 0.46 5.88 0.31 9.98e-9 Blood protein levels; CRC cis rs10878977 1.000 rs10878977 chr12:69799690 C/T cg20891283 chr12:69753455 YEATS4 0.46 6.13 0.32 2.51e-9 Colorectal cancer; CRC cis rs7811142 0.830 rs10085549 chr7:99983135 C/T cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.14 17.15 0.69 1.5e-47 Platelet count; CRC cis rs4589502 1.000 rs2414925 chr15:67129986 A/G cg12317470 chr15:67143691 NA 0.73 6.73 0.35 7.44e-11 Lung cancer (smoking interaction); CRC cis rs7605827 0.930 rs11691286 chr2:15558580 G/T cg19274914 chr2:15703543 NA 0.39 5.95 0.31 6.9e-9 Educational attainment (years of education); CRC cis rs4478137 1.000 rs4478137 chr4:164238385 G/A cg06758707 chr4:164254230 NPY1R 0.39 5.98 0.31 5.87e-9 Subjective well-being (multi-trait analysis);Subjective well-being; CRC cis rs883565 0.771 rs1053530 chr3:39138082 A/G cg01426195 chr3:39028469 NA 0.52 7.89 0.4 4.57e-14 Handedness; CRC cis rs751837 0.591 rs10138133 chr14:103424897 A/G cg10087771 chr14:103399429 CDC42BPB 0.66 6.47 0.34 3.46e-10 Large B-cell lymphoma; CRC cis rs4713118 0.911 rs2394000 chr6:27686991 A/G cg19041857 chr6:27730383 NA -0.44 -6.08 -0.32 3.38e-9 Parkinson's disease; CRC cis rs868943 0.714 rs4415182 chr6:116382811 G/A cg15226275 chr6:116381976 FRK 0.31 7.39 0.38 1.19e-12 Total cholesterol levels; CRC cis rs10504229 0.953 rs115634610 chr8:58190533 G/A cg05313129 chr8:58192883 C8orf71 -0.47 -6.96 -0.36 1.82e-11 Developmental language disorder (linguistic errors); CRC trans rs7618501 1.000 rs57648519 chr3:49813169 C/A cg21582582 chr3:182698605 DCUN1D1 0.56 8.35 0.42 1.88e-15 Intelligence (multi-trait analysis); CRC cis rs9649213 0.593 rs62478233 chr7:98023092 T/C cg21770322 chr7:97807741 LMTK2 0.52 8.52 0.43 5.95e-16 Prostate cancer (SNP x SNP interaction); CRC cis rs2408955 0.501 rs8716 chr12:48539482 T/G cg15465823 chr12:48382534 COL2A1 0.38 6.23 0.32 1.44e-9 Glycated hemoglobin levels; CRC cis rs6762477 0.748 rs2073726 chr3:50223593 T/A cg05623727 chr3:50126028 RBM5 -0.41 -6.91 -0.36 2.48e-11 Menarche (age at onset); CRC cis rs3772130 1.000 rs7427165 chr3:121364624 C/T cg20356878 chr3:121714668 ILDR1 0.49 7.65 0.39 2.22e-13 Cognitive performance; CRC trans rs62103177 0.810 rs62103197 chr18:77632923 G/A cg05926928 chr17:57297772 GDPD1 1.1 10.18 0.49 2.51e-21 Opioid sensitivity; CRC cis rs10791323 0.604 rs2851116 chr11:133705759 G/A cg06766960 chr11:133703094 NA -0.37 -6.17 -0.32 2.02e-9 Childhood ear infection; CRC trans rs747782 0.528 rs624348 chr11:48400795 G/A cg03929089 chr4:120376271 NA -0.62 -6.08 -0.32 3.34e-9 Intraocular pressure; CRC cis rs2270875 0.696 rs10464871 chr8:132931374 C/T cg24184792 chr8:132919238 EFR3A -0.54 -6.11 -0.32 2.77e-9 Response to cholinesterase inhibitors in Alzheimer's disease; CRC cis rs6840360 0.571 rs1978955 chr4:152509509 G/A cg09659197 chr4:152720779 NA 0.31 5.67 0.3 3.05e-8 Intelligence (multi-trait analysis); CRC cis rs654950 0.841 rs2759247 chr1:41991756 G/C cg06885757 chr1:42089581 HIVEP3 -0.35 -6.01 -0.31 4.85e-9 Airway imaging phenotypes; CRC cis rs7192380 0.639 rs2917666 chr16:69763960 C/G cg04110750 chr16:69646130 NFAT5 0.41 6.37 0.33 6.25e-10 Sjögren's syndrome; CRC cis rs9457247 0.663 rs10946205 chr6:167451311 A/G cg07741184 chr6:167504864 NA 0.34 6.1 0.32 2.91e-9 Crohn's disease; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg14361641 chr2:70056642 GMCL1 0.45 6.36 0.33 6.9e-10 Response to antipsychotic treatment; CRC cis rs6502050 0.835 rs8079389 chr17:80158656 T/G cg22110888 chr17:80059540 CCDC57 0.39 6.24 0.33 1.35e-9 Life satisfaction; CRC cis rs9916302 0.851 rs7220650 chr17:37487168 A/G cg03013999 chr17:37608204 MED1 -0.49 -7.68 -0.39 1.86e-13 Glomerular filtration rate (creatinine); CRC cis rs12936587 0.601 rs11655881 chr17:17553133 G/A cg24612305 chr17:17875800 TOM1L2;LRRC48 -0.38 -5.75 -0.3 2.02e-8 Hip circumference;Coronary artery disease or large artery stroke;Coronary heart disease;Coronary artery disease; CRC cis rs1712517 0.771 rs11191664 chr10:105118476 C/T cg05636881 chr10:105038444 INA 0.46 7.92 0.4 3.81e-14 Migraine; CRC cis rs731174 0.959 rs7527344 chr1:38191560 C/A cg06917450 chr1:38156652 C1orf109 -0.49 -6.95 -0.36 2.02e-11 Prostate cancer (SNP x SNP interaction); CRC cis rs11679072 1.000 rs13011626 chr2:240444685 C/T cg03276489 chr2:240449683 NA -0.89 -7.03 -0.36 1.21e-11 Blood pressure (smoking interaction); CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg15790941 chr4:39640517 C4orf34 -0.43 -6.6 -0.34 1.61e-10 Myopia (pathological); CRC cis rs12477438 0.508 rs2516832 chr2:99771268 G/C cg26064155 chr2:99771622 LIPT1;TSGA10 0.88 16.2 0.67 8.61e-44 Chronic sinus infection; CRC cis rs10504229 0.769 rs17804383 chr8:58151830 A/G cg02725872 chr8:58115012 NA -0.57 -9.07 -0.45 1.09e-17 Developmental language disorder (linguistic errors); CRC trans rs2243480 0.901 rs34807232 chr7:65965133 G/A cg10756647 chr7:56101905 PSPH 0.76 7.87 0.4 5.34e-14 Diabetic kidney disease; CRC cis rs365302 0.723 rs391046 chr6:159646232 G/C cg14500486 chr6:159655392 FNDC1 0.43 6.59 0.34 1.76e-10 Coronary heart disease; CRC cis rs2072510 0.593 rs2660900 chr12:96405077 T/C cg09636302 chr12:96389483 HAL -0.51 -6.28 -0.33 1.05e-9 Metabolite levels (small molecules and protein measures); CRC trans rs2228479 0.717 rs2074904 chr16:89811546 A/G cg24644049 chr4:85504048 CDS1 0.9 7.46 0.38 7.69e-13 Skin colour saturation; CRC cis rs13118159 0.550 rs4974617 chr4:1373658 T/C cg05025164 chr4:1340916 KIAA1530 0.56 7.94 0.4 3.16e-14 Longevity; CRC cis rs6540559 1.000 rs7522250 chr1:209962539 T/C cg21951975 chr1:209979733 IRF6 0.46 6.78 0.35 5.59e-11 Cleft lip with or without cleft palate; CRC cis rs394563 0.601 rs431978 chr6:149793000 C/T cg07828024 chr6:149772892 ZC3H12D 0.42 7.27 0.37 2.63e-12 Dupuytren's disease; CRC cis rs6570726 0.935 rs366308 chr6:145814532 T/A cg05347473 chr6:146136440 FBXO30 0.37 5.93 0.31 7.63e-9 Lobe attachment (rater-scored or self-reported); CRC trans rs1656966 1.000 rs1656966 chr3:186466252 C/T cg03868159 chr6:42532252 UBR2 0.41 6.12 0.32 2.66e-9 Myopia (pathological); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg13647118 chr5:82373317 XRCC4;TMEM167A 0.37 6.25 0.33 1.28e-9 Liver disease severity in Alagille syndrome; CRC cis rs7937682 0.663 rs3867466 chr11:111668256 A/C cg19812747 chr11:111475976 SIK2 0.44 6.25 0.33 1.24e-9 Primary sclerosing cholangitis; CRC cis rs919433 0.647 rs2045242 chr2:198507649 G/A cg10820045 chr2:198174542 NA 0.33 5.67 0.3 3.09e-8 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg21229253 chr9:134406525 UCK1 0.36 6.09 0.32 3.17e-9 Liver disease severity in Alagille syndrome; CRC cis rs7312933 0.932 rs10880220 chr12:42383046 A/G cg17420585 chr12:42539391 GXYLT1 -0.39 -5.68 -0.3 2.89e-8 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CRC trans rs10983614 1.000 rs7867776 chr9:120072627 A/G cg25132276 chr5:149546087 CDX1 0.23 6.1 0.32 2.99e-9 Survival in pancreatic cancer; CRC cis rs10504229 0.595 rs76447299 chr8:58117395 A/G cg21724239 chr8:58056113 NA 0.49 6.81 0.35 4.75e-11 Developmental language disorder (linguistic errors); CRC cis rs172166 0.611 rs203882 chr6:28078502 G/A cg12273811 chr6:28175739 NA 0.61 8.84 0.44 5.98e-17 Cardiac Troponin-T levels; CRC cis rs2070677 0.935 rs12261048 chr10:135407923 A/G cg20169779 chr10:135381914 SYCE1 -1.0 -15.67 -0.65 9.85e-42 Gout; CRC cis rs853679 0.517 rs9393898 chr6:28130376 G/T cg02631126 chr6:28058918 ZSCAN12L1 0.29 5.73 0.3 2.26e-8 Depression; CRC cis rs2882667 0.824 rs1560656 chr5:138470789 A/G cg04439458 chr5:138467593 SIL1 0.36 6.23 0.32 1.45e-9 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs6912958 0.559 rs242281 chr6:88048916 A/C cg04972856 chr6:88032051 C6orf162;GJB7 0.31 5.81 0.3 1.5e-8 Monocyte percentage of white cells; CRC cis rs6952808 0.723 rs11765550 chr7:2027324 G/A cg21782813 chr7:2030301 MAD1L1 0.54 9.31 0.46 1.82e-18 Bipolar disorder and schizophrenia; CRC cis rs12024301 0.557 rs74448735 chr1:183645983 T/G cg11505048 chr1:183622726 RGL1;APOBEC4 0.73 6.43 0.33 4.43e-10 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs9467711 0.591 rs67296946 chr6:26048559 T/G cg08501292 chr6:25962987 TRIM38 0.74 7.37 0.38 1.36e-12 Autism spectrum disorder or schizophrenia; CRC cis rs6952808 0.595 rs3778983 chr7:2166319 T/G cg00106254 chr7:1943704 MAD1L1 -0.4 -5.76 -0.3 1.95e-8 Bipolar disorder and schizophrenia; CRC cis rs9814567 0.702 rs9871226 chr3:134331466 A/T cg06109529 chr3:134205091 CEP63;ANAPC13 -0.67 -9.58 -0.47 2.53e-19 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs8005677 0.828 rs2295682 chr14:23374862 C/T cg25600027 chr14:23388339 RBM23 -0.46 -6.99 -0.36 1.5e-11 Cognitive ability (multi-trait analysis); CRC cis rs875971 0.862 rs709609 chr7:65560561 A/G cg00343986 chr7:65444356 GUSB -0.44 -6.31 -0.33 9.16e-10 Aortic root size; CRC cis rs73001065 0.792 rs16996148 chr19:19658472 G/T cg03709012 chr19:19516395 GATAD2A 0.83 5.92 0.31 8.26e-9 LDL cholesterol; CRC cis rs11122272 0.735 rs2790891 chr1:231513190 G/A cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.54 -8.11 -0.41 1.04e-14 Hemoglobin concentration; CRC cis rs4665809 0.590 rs7582341 chr2:26416301 A/G cg04944784 chr2:26401820 FAM59B -0.82 -10.57 -0.5 1.14e-22 Gut microbiome composition (summer); CRC cis rs2625529 0.503 rs7162299 chr15:72414065 A/G cg16672083 chr15:72433130 SENP8 0.44 6.65 0.34 1.23e-10 Red blood cell count; CRC cis rs10540 1.000 rs61877760 chr11:506596 C/T cg15790184 chr11:494944 RNH1 0.61 6.27 0.33 1.14e-9 Body mass index; CRC cis rs801193 0.935 rs3800820 chr7:66147178 C/T cg00343986 chr7:65444356 GUSB -0.5 -7.31 -0.37 2.05e-12 Aortic root size; CRC cis rs473651 0.935 rs1103770 chr2:239339281 G/C cg21699342 chr2:239360505 ASB1 0.52 8.21 0.41 5.22e-15 Multiple system atrophy; CRC trans rs11722228 0.521 rs56403947 chr4:10112529 T/G cg26043149 chr18:55253948 FECH 1.13 17.08 0.69 2.8e-47 Gout;Urate levels;Serum uric acid levels; CRC cis rs1799949 1.000 rs8176145 chr17:41249094 A/G cg25072359 chr17:41440525 NA 0.46 6.87 0.35 3.28e-11 Menopause (age at onset); CRC cis rs9916302 0.904 rs4795355 chr17:37427382 C/T cg03013999 chr17:37608204 MED1 0.48 7.35 0.38 1.59e-12 Glomerular filtration rate (creatinine); CRC cis rs826838 0.900 rs1403523 chr12:39130570 T/A cg13010199 chr12:38710504 ALG10B -0.41 -5.84 -0.31 1.27e-8 Heart rate; CRC cis rs9325144 0.624 rs10506126 chr12:39123244 G/A cg26384229 chr12:38710491 ALG10B -0.45 -6.39 -0.33 5.77e-10 Morning vs. evening chronotype; CRC cis rs34172651 0.545 rs9302428 chr16:24717600 C/G cg06028605 chr16:24865363 SLC5A11 -0.34 -6.6 -0.34 1.64e-10 Intelligence (multi-trait analysis); CRC cis rs7107174 1.000 rs901104 chr11:77930499 C/T cg02023728 chr11:77925099 USP35 0.5 7.18 0.37 4.8e-12 Testicular germ cell tumor; CRC trans rs7142002 0.803 rs12588329 chr14:102363881 G/A cg24202123 chr3:36422093 STAC -0.48 -6.36 -0.33 6.64e-10 Autism; CRC cis rs2882667 0.690 rs288026 chr5:138222594 A/G cg09476006 chr5:138032270 NA 0.55 9.14 0.45 6.76e-18 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs1107366 1.000 rs9874508 chr3:125902417 A/G cg08481491 chr3:125900108 ALDH1L1 0.32 5.73 0.3 2.32e-8 Metabolite levels; CRC cis rs7129220 0.588 rs16907481 chr11:10144108 A/T cg23875677 chr11:10229755 SBF2 -0.53 -5.68 -0.3 3.03e-8 Systolic blood pressure;Diastolic blood pressure;Blood pressure; CRC cis rs2758596 0.850 rs2495270 chr1:156181530 A/G cg25208724 chr1:156163844 SLC25A44 0.72 6.71 0.35 8.6e-11 Paclitaxel disposition in epithelial ovarian cancer; CRC cis rs6860806 0.507 rs272880 chr5:131670178 C/T cg07395648 chr5:131743802 NA -0.4 -5.61 -0.3 4.21e-8 Breast cancer; CRC cis rs4665809 0.590 rs2303892 chr2:26461733 C/G cg04944784 chr2:26401820 FAM59B 0.85 11.05 0.52 2.29e-24 Gut microbiome composition (summer); CRC trans rs3794271 0.706 rs9971816 chr12:20826911 C/T cg13260133 chr10:104626808 NA 0.42 6.15 0.32 2.19e-9 Response to TNF-alpha inhibitors in rheumatoid arthritis; CRC trans rs4714291 0.862 rs2984445 chr6:40069935 C/T cg02267698 chr19:7991119 CTXN1 -0.51 -7.04 -0.36 1.16e-11 Strep throat; CRC trans rs12310956 0.532 rs7955514 chr12:33978737 G/A cg26384229 chr12:38710491 ALG10B 0.51 6.51 0.34 2.81e-10 Morning vs. evening chronotype; CRC cis rs6558174 0.802 rs6558170 chr8:22487388 C/G cg03733263 chr8:22462867 KIAA1967 0.51 6.49 0.34 3.13e-10 Breast cancer; CRC cis rs568617 0.859 rs1204650 chr11:65645580 A/C cg19792802 chr11:65647270 CTSW -0.5 -7.55 -0.38 4.23e-13 Crohn's disease; CRC cis rs6684514 1.000 rs12045339 chr1:156294211 C/T cg16558208 chr1:156270281 VHLL 0.57 8.92 0.44 3.28e-17 Mean corpuscular hemoglobin concentration;Glycated hemoglobin levels; CRC cis rs919433 0.854 rs787994 chr2:198223121 T/C cg03934865 chr2:198174659 NA 0.36 5.95 0.31 7.04e-9 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC cis rs7412746 0.611 rs3768018 chr1:150723747 T/C cg17724175 chr1:150552817 MCL1 0.49 7.23 0.37 3.4e-12 Melanoma; CRC cis rs12760731 0.641 rs10494513 chr1:178252377 C/G cg00404053 chr1:178313656 RASAL2 0.81 8.7 0.43 1.64e-16 Obesity-related traits; CRC cis rs11711311 1.000 rs6792447 chr3:113508335 T/C cg15478005 chr3:113465772 ATP6V1A;NAA50 0.41 5.6 0.3 4.51e-8 IgG glycosylation; CRC cis rs11650494 0.710 rs2119935 chr17:47471334 T/C cg08112188 chr17:47440006 ZNF652 0.67 5.99 0.31 5.63e-9 Prostate cancer; CRC cis rs155076 1.000 rs261430 chr13:21865242 C/T cg25811766 chr13:21894605 NA -0.57 -6.12 -0.32 2.73e-9 White matter hyperintensity burden; CRC cis rs7618915 0.501 rs6804145 chr3:52694198 C/T cg10802521 chr3:52805072 NEK4 -0.56 -8.89 -0.44 4.12e-17 Bipolar disorder; CRC trans rs10504229 1.000 rs9650139 chr8:58190508 G/T cg04077850 chr5:125800366 GRAMD3 0.37 6.26 0.33 1.23e-9 Developmental language disorder (linguistic errors); CRC cis rs9826463 0.582 rs73238185 chr3:142141177 T/C cg20824294 chr3:142316082 PLS1 0.38 6.03 0.32 4.36e-9 QRS duration in Tripanosoma cruzi seropositivity; CRC cis rs950169 0.579 rs12912716 chr15:84664263 A/T cg24253500 chr15:84953950 NA 0.39 6.29 0.33 9.84e-10 Schizophrenia; CRC cis rs9916302 0.904 rs602688 chr17:37439496 C/T cg03013999 chr17:37608204 MED1 0.47 7.13 0.37 6.39e-12 Glomerular filtration rate (creatinine); CRC cis rs13256369 0.802 rs12681326 chr8:8566389 G/A cg00074818 chr8:8560427 CLDN23 0.4 7.07 0.36 9.06e-12 Obesity-related traits; CRC cis rs2576037 0.583 rs8086286 chr18:44467515 A/G cg20875182 chr18:44561130 TCEB3B;KATNAL2 -0.57 -9.43 -0.46 7.83e-19 Personality dimensions; CRC cis rs9549367 0.789 rs2302757 chr13:113909339 A/G cg00898013 chr13:113819073 PROZ -0.47 -6.54 -0.34 2.29e-10 Platelet distribution width; CRC cis rs4722166 0.695 rs35779989 chr7:22800314 A/C cg26061582 chr7:22766209 IL6 0.49 7.83 0.4 6.89e-14 Lung cancer; CRC cis rs2463822 0.844 rs7104149 chr11:62171627 A/G cg06239285 chr11:62104954 ASRGL1 -0.95 -9.55 -0.47 3.09e-19 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs11997175 0.713 rs6997661 chr8:33638554 A/G ch.8.33884649F chr8:33765107 NA -0.39 -6.18 -0.32 1.94e-9 Body mass index; CRC cis rs5769765 0.773 rs9616208 chr22:50313359 G/A cg08270630 chr22:50330655 NA -0.39 -5.61 -0.3 4.19e-8 Schizophrenia; CRC cis rs2120019 0.508 rs8030528 chr15:75171825 C/T cg09165964 chr15:75287851 SCAMP5 -0.65 -7.71 -0.39 1.5e-13 Blood trace element (Zn levels); CRC cis rs9463078 0.691 rs3920903 chr6:45040928 T/A cg25276700 chr6:44698697 NA -0.24 -5.92 -0.31 8.18e-9 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; CRC cis rs10256972 0.591 rs6968988 chr7:1169619 A/G cg23708337 chr7:1209742 NA 0.43 6.66 0.34 1.15e-10 Longevity;Endometriosis; CRC cis rs7677751 1.000 rs7677751 chr4:55124460 C/T cg17187183 chr4:55093834 PDGFRA 0.46 6.07 0.32 3.52e-9 Corneal astigmatism; CRC cis rs1949733 0.959 rs2688242 chr4:8429943 T/G cg11789530 chr4:8429930 ACOX3 0.81 11.73 0.54 9.04e-27 Response to antineoplastic agents; CRC cis rs1044826 0.642 rs9826544 chr3:139162831 A/G cg00490450 chr3:139108681 COPB2 0.48 7.24 0.37 3.2e-12 Obesity-related traits; CRC cis rs1348850 0.567 rs2222711 chr2:178534110 G/T cg22681709 chr2:178499509 PDE11A -0.44 -7.87 -0.4 5.05e-14 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs2239547 0.521 rs9682464 chr3:52888485 C/T cg15147215 chr3:52552868 STAB1 -0.41 -5.78 -0.3 1.72e-8 Schizophrenia; CRC cis rs11650494 0.831 rs73324348 chr17:47455752 G/A cg08112188 chr17:47440006 ZNF652 1.01 10.38 0.5 4.99e-22 Prostate cancer; CRC cis rs10493773 0.609 rs11161660 chr1:86184066 C/T cg17807903 chr1:86174739 ZNHIT6 -0.62 -16.96 -0.68 8.39e-47 Urate levels in overweight individuals; CRC cis rs7666738 0.830 rs6532720 chr4:99043781 C/T cg05340658 chr4:99064831 C4orf37 0.6 9.37 0.46 1.21e-18 Colonoscopy-negative controls vs population controls; CRC cis rs4595586 0.546 rs2056159 chr12:39270417 C/G cg26384229 chr12:38710491 ALG10B 0.52 6.38 0.33 5.92e-10 Morning vs. evening chronotype; CRC cis rs8060686 0.858 rs2271294 chr16:67902326 A/T cg19582491 chr16:67682965 RLTPR -0.39 -5.62 -0.3 4.11e-8 HDL cholesterol;Metabolic syndrome; CRC cis rs1448094 0.512 rs12313775 chr12:86241197 G/A cg19622623 chr12:86230825 RASSF9 -0.41 -6.7 -0.35 9.04e-11 Major depressive disorder; CRC cis rs920590 0.758 rs35896770 chr8:19665616 G/C cg03894339 chr8:19674705 INTS10 0.41 5.69 0.3 2.84e-8 Acute lymphoblastic leukemia (childhood); CRC cis rs853679 0.517 rs9368555 chr6:28108967 T/C cg12273811 chr6:28175739 NA 0.73 9.16 0.45 5.8e-18 Depression; CRC cis rs17666538 1.000 rs61064968 chr8:587933 T/C cg23958373 chr8:599963 NA -0.88 -7.74 -0.39 1.21e-13 IgG glycosylation; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg12655452 chr1:77685094 PIGK 0.39 6.43 0.33 4.55e-10 Liver disease severity in Alagille syndrome; CRC cis rs1008375 0.897 rs3733577 chr4:17649233 T/G cg16339924 chr4:17578868 LAP3 0.52 6.82 0.35 4.43e-11 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs7927771 0.832 rs10769262 chr11:47411581 G/A cg05585544 chr11:47624801 NA 0.53 9.3 0.46 2.09e-18 Subjective well-being; CRC cis rs10504229 0.683 rs11784908 chr8:58131472 T/C cg02725872 chr8:58115012 NA -0.64 -11.55 -0.54 3.85e-26 Developmental language disorder (linguistic errors); CRC cis rs798554 0.757 rs1182176 chr7:2874601 A/G cg14895029 chr7:2775587 GNA12 -0.4 -6.11 -0.32 2.87e-9 Height; CRC cis rs12410462 1.000 rs12410243 chr1:227669474 A/G cg23173402 chr1:227635558 NA 0.66 7.55 0.38 4.28e-13 Major depressive disorder; CRC cis rs6502050 0.835 rs67149434 chr17:80128007 G/A cg19223190 chr17:80058835 NA 0.38 6.02 0.32 4.64e-9 Life satisfaction; CRC cis rs10871290 0.650 rs12600126 chr16:74489732 A/T cg01733217 chr16:74700730 RFWD3 -0.7 -11.35 -0.53 1.97e-25 Breast cancer; CRC cis rs4713118 0.662 rs9393881 chr6:28023751 C/G cg15786705 chr6:28176104 NA 0.66 8.77 0.44 1.01e-16 Parkinson's disease; CRC trans rs1005277 0.579 rs2505248 chr10:38459097 A/G cg27523141 chr10:43048294 ZNF37B 0.49 7.1 0.36 7.91e-12 Extrinsic epigenetic age acceleration; CRC trans rs4650994 1.000 rs10798615 chr1:178513895 T/G cg05059571 chr16:84539110 KIAA1609 -0.48 -7.3 -0.37 2.16e-12 HDL cholesterol levels;HDL cholesterol; CRC cis rs12762955 0.561 rs4880744 chr10:1012026 A/G cg26597838 chr10:835615 NA -0.42 -5.67 -0.3 3.19e-8 Response to angiotensin II receptor blocker therapy; CRC cis rs7312933 0.558 rs7965743 chr12:42736822 A/G cg19980929 chr12:42632907 YAF2 -0.39 -5.89 -0.31 9.33e-9 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CRC cis rs873946 0.648 rs12767283 chr10:134557094 C/G cg18305652 chr10:134549665 INPP5A 0.48 6.1 0.32 2.98e-9 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CRC trans rs2303319 0.504 rs62189042 chr2:162602320 G/T cg10272801 chr16:14013773 ERCC4 -0.68 -6.07 -0.32 3.49e-9 Cognitive function; CRC cis rs2032447 0.702 rs199753 chr6:26001888 G/A cg17691542 chr6:26056736 HIST1H1C 0.42 5.7 0.3 2.69e-8 Intelligence (multi-trait analysis); CRC cis rs12188164 0.965 rs11743639 chr5:450710 C/T cg26850624 chr5:429559 AHRR -0.81 -13.82 -0.61 1.41e-34 Cystic fibrosis severity; CRC cis rs3785574 0.962 rs58131426 chr17:61854375 T/C cg11494091 chr17:61959527 GH2 0.38 5.88 0.31 1e-8 Height; CRC cis rs7659604 0.676 rs4077102 chr4:122699830 A/G cg20573242 chr4:122745356 CCNA2 0.51 7.42 0.38 9.95e-13 Type 2 diabetes; CRC cis rs78545713 0.536 rs78759249 chr6:26208956 G/A cg01420254 chr6:26195488 NA 0.69 6.13 0.32 2.45e-9 Iron status biomarkers (total iron binding capacity); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg12140595 chr2:220093941 ANKZF1;ATG9A 0.45 6.21 0.32 1.59e-9 Response to antipsychotic treatment; CRC cis rs8141529 0.732 rs2269577 chr22:29196757 G/C cg15103426 chr22:29168792 CCDC117 0.6 8.9 0.44 3.78e-17 Lymphocyte counts; CRC cis rs10782582 0.609 rs112431348 chr1:76275571 A/G cg03433033 chr1:76189801 ACADM -0.4 -5.69 -0.3 2.75e-8 Daytime sleep phenotypes; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg06753227 chr18:9475508 RALBP1 0.5 8.18 0.41 6.19e-15 Liver disease severity in Alagille syndrome; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg20913732 chr2:197791419 PGAP1 0.47 6.48 0.34 3.35e-10 Anxiety disorder; CRC cis rs875971 1.000 rs12533997 chr7:65965377 A/G cg11764359 chr7:65958608 NA 0.63 10.25 0.49 1.39e-21 Aortic root size; CRC cis rs185694 1.000 rs653251 chr13:30894542 C/T cg04551440 chr13:30881194 KATNAL1 -0.6 -6.38 -0.33 6.04e-10 Antineutrophil cytoplasmic antibody-associated vasculitis; CRC cis rs10504229 0.639 rs17331850 chr8:58113538 G/T cg02290350 chr8:58132656 NA -0.58 -8.24 -0.41 4.09e-15 Developmental language disorder (linguistic errors); CRC cis rs9309473 0.950 rs10178678 chr2:73762236 A/G cg20560298 chr2:73613845 ALMS1 -0.49 -5.97 -0.31 6.24e-9 Metabolite levels; CRC cis rs2032447 0.901 rs1540276 chr6:26028819 T/G cg12588279 chr6:26043732 HIST1H2BB 0.48 6.9 0.36 2.72e-11 Intelligence (multi-trait analysis); CRC cis rs6076065 0.723 rs2424552 chr20:23402833 G/A cg11657817 chr20:23433608 CST11 0.45 6.56 0.34 2.08e-10 Facial morphology (factor 15, philtrum width); CRC cis rs2271001 0.910 rs11604483 chr11:19144579 C/T cg00161556 chr11:19138045 ZDHHC13 0.34 5.8 0.3 1.58e-8 Gut microbiome composition (winter); CRC cis rs2836974 0.897 rs8128102 chr21:40606414 G/A cg06238570 chr21:40685208 BRWD1 0.78 10.86 0.51 1.12e-23 Cognitive function; CRC cis rs2012796 0.665 rs72703728 chr14:81834523 G/A cg02996355 chr14:81879375 NA 0.58 8.73 0.43 1.3e-16 Night sleep phenotypes; CRC trans rs61931739 0.500 rs11053212 chr12:34466116 T/G cg26384229 chr12:38710491 ALG10B 0.68 8.9 0.44 3.69e-17 Morning vs. evening chronotype; CRC cis rs801193 1.000 rs10234018 chr7:66146284 A/T cg18876405 chr7:65276391 NA -0.59 -10.61 -0.5 8.46e-23 Aortic root size; CRC cis rs853679 0.517 rs9468286 chr6:28079428 C/T cg02631126 chr6:28058918 ZSCAN12L1 0.29 5.87 0.31 1.05e-8 Depression; CRC cis rs12549902 1.000 rs12549902 chr8:41509259 C/T cg17182837 chr8:41585554 ANK1 -0.4 -6.19 -0.32 1.8e-9 Corrected insulin response;Corrected insulin response adjusted for insulin sensitivity index;Insulin levels adjusted for BMI;Type 2 diabetes; CRC cis rs8192917 0.573 rs8010409 chr14:25080289 G/A cg01932691 chr14:25045625 CTSG -0.59 -5.8 -0.3 1.59e-8 Vitiligo; CRC cis rs16867335 1.000 rs34842451 chr2:181480525 C/T cg23363182 chr2:181467187 NA 0.48 6.61 0.34 1.57e-10 Survival in rectal cancer; CRC cis rs62244186 0.748 rs4682987 chr3:44674996 C/T cg15687855 chr3:44754131 ZNF502 -0.35 -5.82 -0.31 1.38e-8 Depressive symptoms; CRC cis rs57502260 0.573 rs11228295 chr11:68388588 C/G cg01657329 chr11:68192670 LRP5 -0.45 -5.64 -0.3 3.74e-8 Total body bone mineral density (age 45-60); CRC cis rs10504229 0.639 rs72650811 chr8:58115661 G/A cg05313129 chr8:58192883 C8orf71 -0.43 -6.11 -0.32 2.74e-9 Developmental language disorder (linguistic errors); CRC cis rs12594515 1.000 rs7172161 chr15:45990780 A/G cg01629716 chr15:45996671 NA 0.41 8.46 0.42 9.03e-16 Waist circumference;Weight; CRC cis rs7827545 1.000 rs1372662 chr8:135567046 C/G cg07299736 chr8:135490787 ZFAT -0.37 -6.39 -0.33 5.73e-10 Hypertension (SNP x SNP interaction); CRC cis rs7107174 1.000 rs11602622 chr11:78010830 A/G cg02023728 chr11:77925099 USP35 0.49 7.82 0.4 7.37e-14 Testicular germ cell tumor; CRC cis rs875971 0.862 rs2088653 chr7:65808608 G/A cg00343986 chr7:65444356 GUSB -0.45 -6.24 -0.33 1.35e-9 Aortic root size; CRC cis rs11586313 1.000 rs11586313 chr1:152890470 C/T cg07796016 chr1:152779584 LCE1C -0.38 -5.67 -0.3 3.19e-8 Vitamin D levels; CRC cis rs7493 0.901 rs17883318 chr7:94958312 G/A cg21856205 chr7:94953877 PON1 -0.43 -6.0 -0.31 5.28e-9 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs2180341 0.576 rs2057224 chr6:127624414 C/G cg24812749 chr6:127587940 RNF146 0.64 9.52 0.46 3.8e-19 Breast cancer; CRC trans rs2228479 0.867 rs2270459 chr16:89979851 A/C cg21302420 chr1:112162376 RAP1A -0.58 -6.12 -0.32 2.65e-9 Skin colour saturation; CRC cis rs13108904 0.901 rs7673398 chr4:1300077 G/A cg16405210 chr4:1374714 KIAA1530 -0.42 -6.07 -0.32 3.5e-9 Obesity-related traits; CRC trans rs1814175 0.817 rs11518158 chr11:49985633 G/T cg11707556 chr5:10655725 ANKRD33B -0.42 -8.01 -0.4 2.02e-14 Height; CRC cis rs11711311 1.000 rs9288982 chr3:113470149 A/C cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.54 -7.01 -0.36 1.33e-11 IgG glycosylation; CRC cis rs4604732 0.631 rs10802509 chr1:247627158 C/T cg12758973 chr1:247694275 LOC148824;OR2C3 0.42 6.14 0.32 2.32e-9 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CRC cis rs2565722 0.622 rs2465844 chr6:161297372 G/C cg03159191 chr6:161285451 NA -0.46 -6.34 -0.33 7.68e-10 Blood protein levels; CRC cis rs1552244 0.935 rs7649243 chr3:10089470 T/A cg18598329 chr3:10140678 FANCD2;C3orf24 -0.87 -11.82 -0.55 4.24e-27 Alzheimer's disease; CRC cis rs8180040 0.764 rs13061071 chr3:47138708 G/A cg27129171 chr3:47204927 SETD2 0.68 10.98 0.52 4.28e-24 Colorectal cancer; CRC trans rs3018066 0.738 rs76654812 chr4:106944699 C/T cg02609279 chr2:182325952 ITGA4 -0.44 -6.1 -0.32 3.04e-9 Cancer; CRC cis rs992157 0.835 rs34353396 chr2:219153982 T/C cg13835894 chr2:219148914 PNKD;TMBIM1 -0.35 -6.72 -0.35 8.24e-11 Colorectal cancer; CRC trans rs875971 0.660 rs2191268 chr7:66110224 C/T cg17601595 chr10:13628739 PRPF18 -0.39 -6.08 -0.32 3.4e-9 Aortic root size; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg02592615 chr6:12012261 HIVEP1 -0.4 -6.21 -0.32 1.58e-9 Myopia (pathological); CRC trans rs10411161 0.702 rs10403189 chr19:52400673 A/G cg22319618 chr22:45562946 NUP50 0.57 5.97 0.31 6.21e-9 Breast cancer; CRC cis rs6500602 1.000 rs12447826 chr16:4464617 T/C cg08645402 chr16:4508243 NA 0.61 10.01 0.48 9.38e-21 Schizophrenia; CRC cis rs734999 0.505 rs10910108 chr1:2539532 A/G cg20673091 chr1:2541236 MMEL1 0.36 5.8 0.3 1.52e-8 Ulcerative colitis; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg21306212 chr13:79979929 RBM26 0.48 7.24 0.37 3.21e-12 Intelligence (multi-trait analysis); CRC cis rs1005277 0.579 rs2021649 chr10:38392122 C/T cg25517755 chr10:38738941 LOC399744 -0.44 -6.43 -0.33 4.37e-10 Extrinsic epigenetic age acceleration; CRC cis rs4819052 1.000 rs9984901 chr21:46663952 C/T cg11663144 chr21:46675770 NA -0.8 -11.82 -0.55 4.1e-27 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs3018066 0.867 rs11931386 chr4:107167983 T/G cg01869342 chr4:106983673 TBCK -0.36 -5.66 -0.3 3.37e-8 Cancer; CRC cis rs6502050 0.835 rs8066284 chr17:80127825 C/T cg19223190 chr17:80058835 NA 0.38 6.02 0.32 4.64e-9 Life satisfaction; CRC cis rs1873147 1.000 rs1873149 chr15:63312428 A/C cg12160578 chr15:63334699 TPM1 0.44 6.31 0.33 9.02e-10 Orofacial clefts; CRC cis rs3806843 0.832 rs2531360 chr5:140116664 G/A cg19875535 chr5:140030758 IK -0.54 -8.68 -0.43 1.81e-16 Depressive symptoms (multi-trait analysis); CRC cis rs9527 0.615 rs4917991 chr10:104783833 T/C cg04362960 chr10:104952993 NT5C2 0.6 8.48 0.42 7.93e-16 Arsenic metabolism; CRC cis rs79349575 0.811 rs1057897 chr17:47005509 T/G cg00947319 chr17:47005597 UBE2Z -0.35 -6.01 -0.31 4.88e-9 Type 2 diabetes; CRC cis rs2456568 0.867 rs4753111 chr11:93658410 A/G cg26875233 chr11:93583750 C11orf90 -0.33 -6.29 -0.33 1.03e-9 Response to serotonin reuptake inhibitors in major depressive disorder; CRC trans rs9858542 0.953 rs6446264 chr3:49417243 C/A cg21659725 chr3:3221576 CRBN -0.63 -8.62 -0.43 2.85e-16 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC trans rs6550704 0.687 rs9865314 chr3:22634337 A/G cg17866984 chr6:43737767 VEGFA -0.44 -6.68 -0.35 1.04e-10 Daytime sleep phenotypes; CRC cis rs2354432 0.607 rs55918563 chr1:146718973 G/C cg25205988 chr1:146714368 CHD1L -1.17 -9.75 -0.47 6.94e-20 Mitochondrial DNA levels; CRC trans rs8002861 0.754 rs7330760 chr13:44403088 A/T cg17145862 chr1:211918768 LPGAT1 -0.49 -8.14 -0.41 8.12e-15 Leprosy; CRC cis rs1568889 1.000 rs10767693 chr11:28093926 G/C cg06544937 chr11:28130018 METT5D1;KIF18A 0.89 14.7 0.63 5.97e-38 Bipolar disorder; CRC cis rs9325144 0.577 rs12314639 chr12:39119869 T/C cg26384229 chr12:38710491 ALG10B -0.45 -6.62 -0.34 1.43e-10 Morning vs. evening chronotype; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg26342734 chr17:7211307 EIF5A 0.45 7.28 0.37 2.54e-12 Liver disease severity in Alagille syndrome; CRC cis rs10504229 0.683 rs6999131 chr8:58127052 C/A cg24829409 chr8:58192753 C8orf71 -0.61 -7.76 -0.39 1.05e-13 Developmental language disorder (linguistic errors); CRC cis rs7666738 0.791 rs1559860 chr4:99024422 C/T cg17366294 chr4:99064904 C4orf37 0.44 7.48 0.38 6.96e-13 Colonoscopy-negative controls vs population controls; CRC cis rs3936840 0.647 rs942024 chr14:102979463 C/T cg18135206 chr14:102964638 TECPR2 0.46 6.12 0.32 2.71e-9 Plateletcrit; CRC cis rs2204008 0.846 rs2030416 chr12:38465118 A/G cg26384229 chr12:38710491 ALG10B -0.66 -9.9 -0.48 2.13e-20 Bladder cancer; CRC cis rs524281 0.861 rs11227403 chr11:65858428 T/C cg14036092 chr11:66035641 RAB1B -0.47 -5.7 -0.3 2.6e-8 Electroencephalogram traits; CRC cis rs62064224 0.597 rs7207268 chr17:30725155 T/G cg18200150 chr17:30822561 MYO1D 0.44 8.53 0.43 5.26e-16 Schizophrenia; CRC cis rs9894429 0.546 rs9906979 chr17:79608765 A/G cg21984481 chr17:79567631 NPLOC4 -0.48 -8.8 -0.44 7.85e-17 Eye color traits; CRC cis rs9522267 0.535 rs9515454 chr13:112236885 A/G cg26182253 chr13:112236782 NA 0.31 6.33 0.33 7.97e-10 Hepatitis; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg24644049 chr4:85504048 CDS1 -0.41 -6.01 -0.31 4.83e-9 Myopia (pathological); CRC cis rs1448094 0.512 rs7299285 chr12:86244959 A/T cg19622623 chr12:86230825 RASSF9 -0.42 -6.78 -0.35 5.42e-11 Major depressive disorder; CRC cis rs4862750 0.794 rs7692427 chr4:187901727 G/A cg27532560 chr4:187881888 NA -0.57 -10.58 -0.5 1.04e-22 Lobe attachment (rater-scored or self-reported); CRC cis rs78456975 0.943 rs13421238 chr2:1576879 G/A cg12573674 chr2:1569213 NA -0.66 -7.37 -0.38 1.42e-12 Placebo response in major depressive disorder (% change in symptom score); CRC cis rs4243830 0.850 rs7540913 chr1:6581877 C/T cg05709478 chr1:6581295 PLEKHG5 -0.54 -6.77 -0.35 5.99e-11 Body mass index; CRC cis rs2976388 0.590 rs7828042 chr8:143819383 A/G cg24046110 chr8:143859143 LYNX1 -0.43 -6.91 -0.36 2.52e-11 Urinary tract infection frequency; CRC cis rs10463316 0.862 rs59390562 chr5:150776092 A/G cg03212797 chr5:150827313 SLC36A1 -0.49 -7.82 -0.4 7.31e-14 Metabolite levels (Pyroglutamine); CRC cis rs4665809 0.531 rs10199898 chr2:26445485 T/G cg25036284 chr2:26402008 FAM59B -0.61 -7.76 -0.39 1.09e-13 Gut microbiome composition (summer); CRC cis rs910316 0.591 rs7157158 chr14:75457238 A/G cg11812906 chr14:75593930 NEK9 0.55 8.32 0.42 2.33e-15 Height; CRC cis rs172166 0.694 rs1150666 chr6:28123928 T/C cg06470822 chr6:28175283 NA 0.82 12.08 0.55 4.78e-28 Cardiac Troponin-T levels; CRC cis rs7666738 0.861 rs13139309 chr4:99020916 A/G cg17366294 chr4:99064904 C4orf37 0.43 7.29 0.37 2.28e-12 Colonoscopy-negative controls vs population controls; CRC cis rs11924390 0.749 rs822364 chr3:186452716 A/G cg04611788 chr3:186434169 KNG1 -0.58 -8.36 -0.42 1.79e-15 Adiponectin levels; CRC trans rs747334 0.846 rs10736059 chr10:92706105 C/A cg19856520 chr1:39696676 MACF1 -0.32 -5.99 -0.31 5.45e-9 Fibroblast growth factor basic levels; CRC cis rs1008375 1.000 rs9291659 chr4:17662360 A/C cg04450456 chr4:17643702 FAM184B 0.43 6.86 0.35 3.36e-11 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs6831352 0.918 rs2602893 chr4:100044095 G/T cg13256891 chr4:100009986 ADH5 0.65 8.7 0.43 1.65e-16 Alcohol dependence; CRC trans rs561341 1.000 rs497479 chr17:30328605 C/T cg20587970 chr11:113659929 NA -1.4 -19.9 -0.74 2.03e-58 Hip circumference adjusted for BMI; CRC trans rs783540 0.967 rs1145173 chr15:83223425 A/G cg18393722 chr15:85113863 UBE2QP1 -0.39 -6.56 -0.34 2.03e-10 Schizophrenia; CRC cis rs9443645 0.901 rs2050662 chr6:79753073 G/C cg09184832 chr6:79620586 NA -0.5 -9.08 -0.45 1e-17 Intelligence (multi-trait analysis); CRC cis rs1005277 0.579 rs1780139 chr10:38503018 C/T cg03665457 chr10:38645376 HSD17B7P2 -0.42 -5.97 -0.31 6.02e-9 Extrinsic epigenetic age acceleration; CRC cis rs6088590 0.561 rs11167239 chr20:33140472 G/A cg24642439 chr20:33292090 TP53INP2 0.41 7.1 0.36 7.95e-12 Coronary artery disease; CRC cis rs2576037 0.796 rs2247021 chr18:44578794 A/C cg19077165 chr18:44547161 KATNAL2 -0.43 -6.7 -0.35 8.8e-11 Personality dimensions; CRC cis rs57221529 0.766 rs4081847 chr5:574072 C/T cg09021430 chr5:549028 NA -0.66 -7.37 -0.38 1.35e-12 Lung disease severity in cystic fibrosis; CRC cis rs6676180 0.514 rs868675 chr1:119773596 A/G cg05756136 chr1:119680316 WARS2 -0.5 -7.5 -0.38 5.96e-13 Monobrow; CRC cis rs977987 0.771 rs8048527 chr16:75422054 C/A cg03315344 chr16:75512273 CHST6 0.54 9.1 0.45 9.18e-18 Dupuytren's disease; CRC trans rs7395662 0.856 rs117753969 chr11:48760328 G/A cg21153622 chr11:89784906 NA -0.48 -7.79 -0.39 8.59e-14 HDL cholesterol; CRC cis rs6062302 0.545 rs2297430 chr20:62229244 T/C cg16989086 chr20:62203971 PRIC285 0.47 6.03 0.32 4.52e-9 Glioblastoma; CRC cis rs56235845 0.694 rs36102285 chr5:176774018 C/T cg05207973 chr5:176823642 SLC34A1 0.34 5.7 0.3 2.7e-8 Hemoglobin concentration;Hematocrit; CRC cis rs62408225 0.888 rs58453446 chr6:90948093 G/C cg06866423 chr6:90926672 BACH2 0.48 7.79 0.39 9.02e-14 Eosinophil counts;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC cis rs8067545 0.616 rs203477 chr17:19831819 A/C cg04132472 chr17:19861366 AKAP10 0.42 6.66 0.34 1.14e-10 Schizophrenia; CRC cis rs6499255 1.000 rs6499255 chr16:69830328 A/G cg15192750 chr16:69999425 NA 0.49 6.5 0.34 2.91e-10 IgE levels; CRC cis rs7937682 0.921 rs10789841 chr11:111469582 T/C cg09085632 chr11:111637200 PPP2R1B 1.0 15.86 0.66 1.75e-42 Primary sclerosing cholangitis; CRC cis rs11098499 0.618 rs28491261 chr4:120294900 C/A cg09307838 chr4:120376055 NA 0.71 10.88 0.51 9.53e-24 Corneal astigmatism; CRC trans rs1814175 0.791 rs10839468 chr11:49986288 A/G cg21153622 chr11:89784906 NA -0.37 -6.03 -0.32 4.33e-9 Height; CRC cis rs1355223 0.506 rs11032899 chr11:34870234 G/A cg11058730 chr11:34937778 PDHX;APIP -0.43 -6.08 -0.32 3.26e-9 Systemic lupus erythematosus and Systemic sclerosis; CRC cis rs1552244 1.000 rs7648104 chr3:10073311 C/A cg10729496 chr3:10149963 C3orf24 0.55 7.11 0.37 7.07e-12 Alzheimer's disease; CRC cis rs11212617 1.000 rs228598 chr11:108107497 T/G cg14761454 chr11:108092087 ATM;NPAT 0.43 6.44 0.33 4.34e-10 Response to metformin in type 2 diabetes (glycemic); CRC cis rs12188164 0.515 rs11742006 chr5:408529 C/T cg26850624 chr5:429559 AHRR -0.72 -11.22 -0.53 5.9e-25 Cystic fibrosis severity; CRC cis rs11098499 0.954 rs7656252 chr4:120404268 T/C cg24375607 chr4:120327624 NA 0.49 7.68 0.39 1.78e-13 Corneal astigmatism; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg03150279 chr9:127905984 SCAI 0.45 6.24 0.33 1.38e-9 Response to antipsychotic treatment; CRC cis rs6951245 0.935 rs112554101 chr7:1065535 A/G cg26224354 chr7:1096374 C7orf50;GPR146 -0.71 -9.9 -0.48 2.22e-20 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs6840360 0.642 rs7698816 chr4:152352972 C/T cg09659197 chr4:152720779 NA 0.34 6.65 0.34 1.24e-10 Intelligence (multi-trait analysis); CRC cis rs422249 0.512 rs174562 chr11:61585144 A/G cg06781209 chr11:61594997 FADS2 -0.38 -5.64 -0.3 3.68e-8 Trans fatty acid levels; CRC cis rs4731207 0.596 rs7799523 chr7:124592033 C/T cg23710748 chr7:124431027 NA -0.38 -6.03 -0.32 4.4e-9 Cutaneous malignant melanoma; CRC cis rs6710529 1 rs6710529 chr2:219645553 G/A cg02176678 chr2:219576539 TTLL4 -0.45 -7.15 -0.37 5.66e-12 Lobe attachment (rater-scored or self-reported); CRC cis rs736408 0.522 rs11130310 chr3:52674667 C/T cg10802521 chr3:52805072 NEK4 -0.56 -8.81 -0.44 7.42e-17 Bipolar disorder; CRC cis rs9322817 0.691 rs6922441 chr6:105216405 T/C cg02098413 chr6:105308735 HACE1 -0.44 -8.51 -0.42 6.37e-16 Thyroid stimulating hormone; CRC cis rs7927771 1.000 rs35902101 chr11:47795169 C/T cg18512352 chr11:47633146 NA -0.49 -9.48 -0.46 5.08e-19 Subjective well-being; CRC trans rs7618501 0.633 rs12496973 chr3:50002245 T/C cg21659725 chr3:3221576 CRBN 0.54 8.53 0.43 5.26e-16 Intelligence (multi-trait analysis); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg13278359 chr4:170678860 C4orf27 0.41 6.16 0.32 2.15e-9 Liver disease severity in Alagille syndrome; CRC cis rs896854 0.540 rs2011567 chr8:95971920 G/A cg13393036 chr8:95962371 TP53INP1 -0.54 -9.28 -0.46 2.26e-18 Type 2 diabetes; CRC cis rs10256972 0.630 rs13235747 chr7:1129123 T/C cg27094323 chr7:1216898 NA -0.38 -6.11 -0.32 2.8e-9 Longevity;Endometriosis; CRC cis rs9311474 0.597 rs13303 chr3:52558008 T/C cg18099408 chr3:52552593 STAB1 -0.63 -12.2 -0.56 1.66e-28 Electroencephalogram traits; CRC cis rs4481887 1.000 rs10888362 chr1:248483975 A/G cg00666640 chr1:248458726 OR2T12 -0.56 -9.84 -0.48 3.26e-20 Common traits (Other); CRC cis rs9896933 0.779 rs2256316 chr17:80693805 C/G cg20578329 chr17:80767326 TBCD -0.81 -9.81 -0.48 4.34e-20 Bone mineral accretion in asthma (oral corticosteroid dose interaction); CRC cis rs7618915 0.571 rs12487445 chr3:52618319 A/C cg07507251 chr3:52567010 NT5DC2 0.46 6.58 0.34 1.82e-10 Bipolar disorder; CRC cis rs11098499 0.780 rs7692994 chr4:120427489 C/A cg09307838 chr4:120376055 NA 0.66 10.11 0.49 4.05e-21 Corneal astigmatism; CRC cis rs5758511 0.773 rs62241023 chr22:42385429 G/A cg00645731 chr22:42541494 CYP2D7P1 0.5 7.36 0.38 1.46e-12 Birth weight; CRC cis rs8105895 0.935 rs62111039 chr19:22287336 C/G cg02912127 chr19:22235281 ZNF257 -0.41 -5.69 -0.3 2.77e-8 Body mass index (change over time); CRC cis rs8060686 0.641 rs7204974 chr16:68033539 G/A cg26727032 chr16:67993705 SLC12A4 -0.62 -8.37 -0.42 1.62e-15 HDL cholesterol;Metabolic syndrome; CRC cis rs7927771 0.542 rs7122217 chr11:47777920 G/C cg20307385 chr11:47447363 PSMC3 -0.45 -6.64 -0.34 1.28e-10 Subjective well-being; CRC cis rs1007738 0.580 rs61897844 chr11:47190860 G/A cg19486271 chr11:47235900 DDB2 0.45 5.89 0.31 9.63e-9 Bone mineral density (hip); CRC cis rs9733 0.596 rs7418501 chr1:150711896 A/T cg10589385 chr1:150898437 SETDB1 0.27 5.72 0.3 2.36e-8 Tonsillectomy; CRC cis rs6500395 1.000 rs11643264 chr16:48558462 A/G cg04672837 chr16:48644449 N4BP1 0.41 5.88 0.31 1e-8 Response to tocilizumab in rheumatoid arthritis; CRC cis rs7666738 0.830 rs1124253 chr4:98949682 C/T cg05340658 chr4:99064831 C4orf37 0.61 9.54 0.47 3.45e-19 Colonoscopy-negative controls vs population controls; CRC cis rs3845702 1.000 rs3738943 chr2:180846743 G/T cg23417306 chr2:180868811 CWC22 -0.44 -6.03 -0.32 4.31e-9 Schizophrenia; CRC cis rs12142240 0.659 rs1984491 chr1:46858607 T/G cg14993813 chr1:46806288 NSUN4 -0.48 -6.03 -0.32 4.47e-9 Menopause (age at onset); CRC cis rs9399135 0.967 rs4896121 chr6:135293645 T/C cg22676075 chr6:135203613 NA 0.44 6.86 0.35 3.41e-11 Red blood cell count; CRC cis rs10504073 0.647 rs9643394 chr8:50014427 A/G cg00325661 chr8:49890786 NA 0.45 8.21 0.41 4.98e-15 Blood metabolite ratios; CRC cis rs34172651 0.517 rs3803716 chr16:24802325 C/T cg06505273 chr16:24850292 NA 0.48 6.13 0.32 2.47e-9 Intelligence (multi-trait analysis); CRC cis rs10911251 0.546 rs3768625 chr1:183078712 G/T ch.1.3577855R chr1:183094577 LAMC1 0.87 15.32 0.65 2.33e-40 Colorectal cancer; CRC cis rs9814567 0.806 rs13076825 chr3:134317239 G/A cg06109529 chr3:134205091 CEP63;ANAPC13 0.69 10.33 0.49 7.64e-22 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs9818758 0.607 rs73074866 chr3:49626666 C/T cg01304814 chr3:48885189 PRKAR2A 0.79 5.91 0.31 8.34e-9 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; CRC cis rs853679 0.546 rs34295134 chr6:27828151 T/A cg15845792 chr6:28175446 NA 0.71 6.18 0.32 1.89e-9 Depression; CRC cis rs11971779 0.590 rs6467839 chr7:139062790 T/C cg07862535 chr7:139043722 LUC7L2 0.57 7.33 0.37 1.78e-12 Diisocyanate-induced asthma; CRC cis rs7208859 0.573 rs73267872 chr17:29067207 T/C cg13385521 chr17:29058706 SUZ12P 0.72 8.17 0.41 6.77e-15 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC trans rs1005277 0.522 rs200943 chr10:38148730 A/G cg17830980 chr10:43048298 ZNF37B -0.41 -6.35 -0.33 7.33e-10 Extrinsic epigenetic age acceleration; CRC trans rs11039798 0.660 rs28435129 chr11:48629795 A/T cg15704280 chr7:45808275 SEPT13 0.65 6.76 0.35 6.42e-11 Axial length; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg06100899 chr20:44035415 DBNDD2;SYS1-DBNDD2 0.43 6.25 0.33 1.28e-9 Anxiety disorder; CRC cis rs2288073 0.965 rs13395596 chr2:24410738 T/C cg06627628 chr2:24431161 ITSN2 -0.72 -9.69 -0.47 1.09e-19 Venous thromboembolism (SNP x SNP interaction); CRC cis rs79839061 0.610 rs2306252 chr4:892116 T/C cg14530993 chr4:882597 GAK 0.62 6.3 0.33 9.76e-10 Intelligence (multi-trait analysis); CRC cis rs72945132 0.882 rs61177215 chr11:70129534 G/A cg00319359 chr11:70116639 PPFIA1 0.6 6.82 0.35 4.5e-11 Coronary artery disease; CRC cis rs6582630 0.555 rs10785454 chr12:38476260 C/T cg26384229 chr12:38710491 ALG10B 0.72 10.11 0.49 4.19e-21 Drug-induced liver injury (flucloxacillin); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg04561332 chr2:20550539 NA 0.47 6.45 0.34 4e-10 Response to antipsychotic treatment; CRC cis rs4665809 0.590 rs34728554 chr2:26481959 C/G cg25036284 chr2:26402008 FAM59B 0.62 7.86 0.4 5.64e-14 Gut microbiome composition (summer); CRC cis rs9747201 1.000 rs58119191 chr17:80155329 T/C cg09264619 chr17:80180166 NA -0.5 -7.28 -0.37 2.49e-12 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs7044106 0.762 rs1411158 chr9:123464804 A/G cg14255062 chr9:123606675 PSMD5;LOC253039 0.44 6.75 0.35 6.82e-11 Hip circumference adjusted for BMI; CRC cis rs881375 0.867 rs6478487 chr9:123672777 C/T cg09586646 chr9:123605570 PSMD5;LOC253039 0.51 6.96 0.36 1.82e-11 Rheumatoid arthritis; CRC cis rs6901250 0.851 rs2175622 chr6:117149667 T/A cg12892004 chr6:117198278 RFX6 0.45 6.96 0.36 1.9e-11 C-reactive protein levels; CRC cis rs6951245 1.000 rs74652290 chr7:1090109 G/A cg26224354 chr7:1096374 C7orf50;GPR146 -0.87 -11.14 -0.52 1.13e-24 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs2153535 0.580 rs2184584 chr6:8468407 T/C cg21535247 chr6:8435926 SLC35B3 0.5 7.53 0.38 4.89e-13 Motion sickness; CRC trans rs8097070 0.661 rs9966711 chr18:23171413 C/G cg09418612 chr17:46019174 PNPO 0.54 6.26 0.33 1.17e-9 Systemic juvenile idiopathic arthritis; CRC cis rs6546550 0.904 rs3771537 chr2:70038792 A/C cg02498382 chr2:70120550 SNRNP27 -0.4 -6.42 -0.33 4.74e-10 Prevalent atrial fibrillation; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg12633356 chr12:51318640 METTL7A 0.39 6.29 0.33 9.95e-10 Response to antipsychotic treatment; CRC cis rs2836974 0.897 rs2836944 chr21:40593539 G/A cg17971929 chr21:40555470 PSMG1 0.81 11.64 0.54 1.81e-26 Cognitive function; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg10158674 chr1:51426069 FAF1 0.46 6.4 0.33 5.22e-10 Response to antipsychotic treatment; CRC cis rs7666738 0.830 rs7664340 chr4:99037820 C/T cg05340658 chr4:99064831 C4orf37 0.59 8.98 0.44 2.1e-17 Colonoscopy-negative controls vs population controls; CRC trans rs9919625 1.000 rs4307711 chr11:11592236 C/T cg26272220 chr12:81471884 ACSS3 -0.38 -6.57 -0.34 1.99e-10 Exploratory eye movement dysfunction in schizophrenia (cognitive search score);Exploratory eye movement dysfunction in schizophrenia (responsive search score); CRC cis rs12188164 1.000 rs55842567 chr5:437586 G/A cg16322479 chr5:444228 EXOC3;C5orf55 0.48 7.84 0.4 6.19e-14 Cystic fibrosis severity; CRC cis rs1062753 0.961 rs9620007 chr22:42405657 C/G cg00645731 chr22:42541494 CYP2D7P1 0.4 6.93 0.36 2.16e-11 Response to serotonin reuptake inhibitors in major depressive disorder (plasma drug and metabolite levels); CRC cis rs734999 0.588 rs3748819 chr1:2524966 C/T cg20673091 chr1:2541236 MMEL1 0.35 5.64 0.3 3.59e-8 Ulcerative colitis; CRC cis rs270601 0.770 rs1007602 chr5:131602166 T/C cg24060327 chr5:131705240 SLC22A5 -0.4 -6.22 -0.32 1.49e-9 Acylcarnitine levels; CRC cis rs17756712 0.667 rs72835984 chr6:642017 C/T cg16786516 chr6:604617 EXOC2 0.51 6.49 0.34 3.09e-10 Vertical cup-disc ratio; CRC cis rs4713118 0.586 rs9468290 chr6:28087674 C/T cg15786705 chr6:28176104 NA 0.76 9.47 0.46 5.57e-19 Parkinson's disease; CRC cis rs2303745 0.589 rs10401700 chr19:17397700 A/C cg04248312 chr19:17393744 ANKLE1 -0.85 -13.03 -0.58 1.45e-31 Systemic lupus erythematosus; CRC cis rs9611565 0.729 rs73176686 chr22:41782119 C/T cg06634786 chr22:41940651 POLR3H -0.69 -7.86 -0.4 5.41e-14 Vitiligo; CRC cis rs709400 0.859 rs942863 chr14:104021268 C/T cg12935359 chr14:103987150 CKB -0.4 -6.12 -0.32 2.65e-9 Body mass index; CRC cis rs908922 0.651 rs1337341 chr1:152508259 A/C cg23254163 chr1:152506842 NA 0.47 8.98 0.44 2.16e-17 Hair morphology; CRC cis rs7914558 0.869 rs10883842 chr10:104941589 C/T cg04362960 chr10:104952993 NT5C2 0.59 8.75 0.43 1.11e-16 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs35110281 0.837 rs2838336 chr21:45071741 A/G cg01579765 chr21:45077557 HSF2BP 0.39 7.52 0.38 5.15e-13 Mean corpuscular volume; CRC cis rs28386778 0.897 rs6504176 chr17:61811920 T/C cg06601766 chr17:61851465 DDX42;CCDC47 0.44 5.97 0.31 6.02e-9 Prudent dietary pattern; CRC cis rs644799 0.965 rs10831425 chr11:95500628 T/C cg03916912 chr11:95522834 CEP57;FAM76B 0.95 17.58 0.7 3.1e-49 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs7833986 0.501 rs2953901 chr8:56981824 C/A cg23139584 chr8:56987506 RPS20;SNORD54 0.91 12.57 0.57 7.49e-30 Height; CRC cis rs2179367 0.881 rs2744432 chr6:149743871 A/C cg11245181 chr6:149772854 ZC3H12D 0.39 5.78 0.3 1.73e-8 Dupuytren's disease; CRC cis rs780096 0.546 rs715325 chr2:27725572 C/A cg22903471 chr2:27725779 GCKR -0.37 -6.12 -0.32 2.69e-9 Total body bone mineral density; CRC cis rs7917772 0.502 rs4919670 chr10:104515799 C/A cg11453585 chr10:104263688 ACTR1A;SUFU -0.64 -9.56 -0.47 2.88e-19 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC cis rs1881396 0.531 rs4665385 chr2:27930837 C/T cg27432699 chr2:27873401 GPN1 0.58 6.53 0.34 2.48e-10 Nonalcoholic fatty liver disease; CRC cis rs1278769 1.000 rs1278769 chr13:113536627 C/T cg00823993 chr13:113535758 ATP11A 0.52 7.34 0.38 1.71e-12 Interstitial lung disease; CRC cis rs7542091 0.704 rs1108628 chr1:210041150 A/G cg22029157 chr1:209979665 IRF6 0.48 7.41 0.38 1.05e-12 Monobrow; CRC cis rs7917772 0.503 rs56397707 chr10:104302693 T/C cg22532475 chr10:104410764 TRIM8 -0.36 -6.62 -0.34 1.43e-10 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC cis rs13191362 1.000 rs36107456 chr6:162997399 T/G cg06582575 chr6:163149167 PACRG;PARK2 0.74 10.67 0.51 5.17e-23 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs3772130 0.923 rs13434284 chr3:121482842 C/A cg20356878 chr3:121714668 ILDR1 0.51 7.9 0.4 4.1e-14 Cognitive performance; CRC cis rs35306767 0.903 rs12260800 chr10:927933 T/C cg26597838 chr10:835615 NA 0.94 11.56 0.54 3.59e-26 Eosinophil percentage of granulocytes; CRC trans rs4295623 0.585 rs34421088 chr8:11589042 A/G cg06636001 chr8:8085503 FLJ10661 -0.57 -8.47 -0.42 8.11e-16 Morning vs. evening chronotype; CRC cis rs6918586 0.658 rs198838 chr6:26113340 C/T cg18357526 chr6:26021779 HIST1H4A 0.5 7.54 0.38 4.63e-13 Schizophrenia; CRC cis rs933688 1.000 rs12655973 chr5:90736537 A/G cg26981201 chr5:90679533 LOC100129716;ARRDC3 1.0 16.53 0.67 4.33e-45 Smoking behavior; CRC trans rs9326248 0.953 rs488962 chr11:117072525 C/T cg18755114 chr2:209119030 IDH1 0.4 5.99 0.31 5.6e-9 Blood protein levels; CRC trans rs7937682 0.924 rs875257 chr11:111530453 A/G cg18187862 chr3:45730750 SACM1L 0.47 6.82 0.35 4.38e-11 Primary sclerosing cholangitis; CRC cis rs372883 0.507 rs8132992 chr21:30750561 T/C cg24692254 chr21:30365293 RNF160 0.54 8.51 0.42 6.45e-16 Pancreatic cancer; CRC cis rs477692 0.673 rs10829600 chr10:131322051 G/C cg05714579 chr10:131428358 MGMT 0.5 6.96 0.36 1.81e-11 Response to temozolomide; CRC cis rs2976388 0.609 rs2585140 chr8:143806896 A/G cg04969067 chr8:143858791 LYNX1 0.44 7.47 0.38 7.28e-13 Urinary tract infection frequency; CRC trans rs4714291 0.698 rs9296321 chr6:40118352 C/T cg02267698 chr19:7991119 CTXN1 -0.44 -5.98 -0.31 5.74e-9 Strep throat; CRC cis rs1865760 0.532 rs9295687 chr6:26082710 T/C cg17691542 chr6:26056736 HIST1H1C 0.56 8.51 0.42 6.1e-16 Height; CRC cis rs250677 0.687 rs2915809 chr5:148452111 A/T cg23229984 chr5:148520753 ABLIM3 0.5 7.04 0.36 1.11e-11 Breast cancer; CRC cis rs10464366 0.544 rs4355688 chr7:39158402 C/T cg21665744 chr7:39171113 POU6F2 0.45 5.96 0.31 6.67e-9 IgG glycosylation; CRC cis rs10504229 0.683 rs58883273 chr8:58138275 A/G cg02290350 chr8:58132656 NA -0.58 -8.16 -0.41 7.29e-15 Developmental language disorder (linguistic errors); CRC cis rs1953600 0.645 rs2819945 chr10:81952956 G/A cg11900509 chr10:81946545 ANXA11 0.38 6.17 0.32 1.98e-9 Sarcoidosis; CRC trans rs10983614 1.000 rs7867776 chr9:120072627 A/G cg17942371 chr19:796826 PTBP1 0.45 6.26 0.33 1.22e-9 Survival in pancreatic cancer; CRC cis rs79349575 0.715 rs1058018 chr17:47000251 C/T cg22482690 chr17:47019901 SNF8 0.44 7.27 0.37 2.66e-12 Type 2 diabetes; CRC cis rs9611565 0.592 rs4822038 chr22:41958495 G/A cg03806693 chr22:41940476 POLR3H -1.11 -13.22 -0.59 2.67e-32 Vitiligo; CRC cis rs4481887 0.741 rs6674078 chr1:248543026 G/A cg26353448 chr1:248524236 OR2T4 -0.32 -6.17 -0.32 2.02e-9 Common traits (Other); CRC cis rs7666738 0.962 rs2865985 chr4:99068009 T/C cg03676636 chr4:99064102 C4orf37 0.22 5.91 0.31 8.47e-9 Colonoscopy-negative controls vs population controls; CRC cis rs7487075 0.786 rs898242 chr12:46720819 C/T cg22049899 chr12:47219821 SLC38A4 0.33 6.35 0.33 7.27e-10 Itch intensity from mosquito bite; CRC cis rs4862750 1.000 rs4862751 chr4:187904050 G/A cg11301795 chr4:187892539 NA -0.89 -19.66 -0.73 1.85e-57 Lobe attachment (rater-scored or self-reported); CRC cis rs738321 0.711 rs5995541 chr22:38553411 C/T cg25457927 chr22:38595422 NA -0.34 -6.6 -0.34 1.62e-10 Breast cancer; CRC trans rs2228479 0.850 rs62052660 chr16:89847420 T/A cg24644049 chr4:85504048 CDS1 0.92 7.68 0.39 1.79e-13 Skin colour saturation; CRC cis rs1670533 1.000 rs10003009 chr4:1050849 G/A cg27284194 chr4:1044797 NA 0.51 6.23 0.33 1.39e-9 Recombination rate (females); CRC cis rs3812049 0.784 rs2568928 chr5:127487603 C/T cg25462716 chr5:127418816 SLC12A2;FLJ33630 -0.7 -8.71 -0.43 1.5e-16 Lymphocyte counts;Red cell distribution width; CRC cis rs6754311 0.773 rs680428 chr2:136630757 A/G cg15123519 chr2:136567270 LCT 0.35 6.87 0.35 3.17e-11 Mosquito bite size; CRC cis rs600231 0.665 rs1616810 chr11:65220105 A/G cg17120908 chr11:65337727 SSSCA1 -0.56 -8.35 -0.42 1.93e-15 Bone mineral density; CRC cis rs9443645 0.869 rs4706747 chr6:79722639 A/G cg11833968 chr6:79620685 NA -0.35 -6.04 -0.32 4.19e-9 Intelligence (multi-trait analysis); CRC cis rs478304 0.934 rs669742 chr11:65501291 C/T cg27068330 chr11:65405492 SIPA1 0.43 6.35 0.33 7.22e-10 Acne (severe); CRC cis rs6840360 0.554 rs13108359 chr4:152727852 T/C cg09659197 chr4:152720779 NA -0.45 -9.24 -0.45 3.18e-18 Intelligence (multi-trait analysis); CRC cis rs9326248 0.539 rs7120565 chr11:117042949 T/C cg11861562 chr11:117069780 TAGLN 0.31 7.01 0.36 1.38e-11 Blood protein levels; CRC cis rs4713118 0.662 rs149948 chr6:27974817 C/G cg21251018 chr6:28226885 NKAPL 0.46 6.94 0.36 2.06e-11 Parkinson's disease; CRC cis rs9649213 0.593 rs736753 chr7:97931489 G/T cg24562669 chr7:97807699 LMTK2 0.42 7.01 0.36 1.36e-11 Prostate cancer (SNP x SNP interaction); CRC cis rs8141529 0.748 rs5762882 chr22:29290680 C/A cg15103426 chr22:29168792 CCDC117 0.48 6.61 0.34 1.52e-10 Lymphocyte counts; CRC cis rs10089 0.680 rs3805616 chr5:127520897 C/T cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.76 7.25 0.37 3e-12 Ileal carcinoids; CRC cis rs6088580 0.634 rs6087587 chr20:33058628 G/T cg08999081 chr20:33150536 PIGU 0.61 11.44 0.53 9.33e-26 Glomerular filtration rate (creatinine); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg07732421 chr5:74633253 HMGCR 0.44 6.3 0.33 9.37e-10 Response to antipsychotic treatment; CRC cis rs7131987 0.903 rs7974221 chr12:29399448 A/G cg09582351 chr12:29534625 ERGIC2 -0.29 -6.18 -0.32 1.91e-9 QT interval; CRC cis rs933688 1.000 rs10073657 chr5:90689749 G/A cg26981201 chr5:90679533 LOC100129716;ARRDC3 1.03 17.99 0.7 7.02e-51 Smoking behavior; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg12364570 chr5:134074118 CAMLG 0.42 6.17 0.32 2.06e-9 Intelligence (multi-trait analysis); CRC cis rs7618501 0.633 rs4688690 chr3:50022292 G/A cg24308560 chr3:49941425 MST1R -0.51 -8.22 -0.41 4.87e-15 Intelligence (multi-trait analysis); CRC cis rs9309473 0.718 rs10175529 chr2:73606093 A/G cg20560298 chr2:73613845 ALMS1 -0.51 -7.19 -0.37 4.29e-12 Metabolite levels; CRC cis rs2949837 0.581 rs2960434 chr7:45972977 A/G cg10677697 chr7:45961126 IGFBP3 0.34 6.01 0.31 5.03e-9 Sitting height ratio; CRC cis rs2745967 0.791 rs2785646 chr1:208076291 G/A cg09788693 chr1:208063733 CD34 0.42 6.44 0.33 4.29e-10 Resting heart rate; CRC trans rs4263408 0.934 rs9683743 chr4:39703194 A/C cg21169611 chr9:106856078 SMC2 -0.41 -5.98 -0.31 5.86e-9 Plasma amyloid beta peptide concentrations (ABx-40); CRC cis rs9303401 0.614 rs34843288 chr17:57103140 T/C cg10487724 chr17:56770010 TEX14;RAD51C 0.77 8.74 0.43 1.23e-16 Cognitive test performance; CRC cis rs75920871 0.588 rs1815788 chr11:116834971 T/C cg01368799 chr11:117014884 PAFAH1B2 -0.42 -5.93 -0.31 7.55e-9 Subjective well-being; CRC cis rs6121246 0.909 rs6058463 chr20:30385192 C/T cg13852791 chr20:30311386 BCL2L1 0.72 11.41 0.53 1.22e-25 Mean corpuscular hemoglobin; CRC cis rs2629540 0.847 rs10901811 chr10:126417914 G/A cg08799069 chr10:126477246 METTL10 0.63 8.11 0.41 9.88e-15 Cocaine dependence; CRC cis rs10504229 0.724 rs16922734 chr8:58111192 C/T cg21724239 chr8:58056113 NA 0.5 6.89 0.35 2.89e-11 Developmental language disorder (linguistic errors); CRC cis rs4713118 0.869 rs9461401 chr6:27703291 G/A cg19041857 chr6:27730383 NA -0.41 -6.0 -0.31 5.3300000000000004e-09 Parkinson's disease; CRC cis rs6951245 0.744 rs10265758 chr7:1172518 C/T cg03188948 chr7:1209495 NA 0.61 6.94 0.36 2.13e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs6940638 0.662 rs6915678 chr6:27235866 T/G cg12292205 chr6:26970375 C6orf41 -0.52 -7.48 -0.38 6.69e-13 Intelligence (multi-trait analysis); CRC cis rs1862618 0.853 rs2113079 chr5:56157951 A/G cg22800045 chr5:56110881 MAP3K1 0.52 5.73 0.3 2.22e-8 Initial pursuit acceleration; CRC cis rs9372498 0.536 rs62421536 chr6:118727972 G/A cg01339444 chr6:118972232 C6orf204 0.57 6.13 0.32 2.54e-9 Diastolic blood pressure; CRC cis rs2274273 0.840 rs2009291 chr14:55838230 A/C cg23234261 chr14:55582407 NA 0.29 5.65 0.3 3.56e-8 Protein biomarker; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg09008063 chr16:25026527 ARHGAP17 0.43 6.1 0.32 3.04e-9 Response to antipsychotic treatment; CRC cis rs2019137 0.560 rs7578633 chr2:113978650 C/T cg21482265 chr2:113992762 PAX8;LOC440839;LOC654433 0.64 9.6 0.47 2.07e-19 Lymphocyte counts; CRC cis rs1008375 0.966 rs3775927 chr4:17599894 G/T cg16339924 chr4:17578868 LAP3 0.62 8.33 0.42 2.21e-15 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs10464366 0.746 rs62442210 chr7:39146328 G/T cg15212455 chr7:39170539 POU6F2 0.45 5.83 0.31 1.33e-8 IgG glycosylation; CRC cis rs7727544 0.584 rs7714191 chr5:131341541 C/G cg12564285 chr5:131593104 PDLIM4 0.35 6.29 0.33 1e-9 Blood metabolite levels; CRC cis rs9611565 0.559 rs132768 chr22:42013523 C/A cg06634786 chr22:41940651 POLR3H 0.65 7.08 0.36 8.92e-12 Vitiligo; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg26789489 chr1:16941426 NBPF1 -0.34 -6.16 -0.32 2.08e-9 Liver disease severity in Alagille syndrome; CRC cis rs1223397 0.938 rs9395602 chr6:13278753 C/T cg07912922 chr6:13274314 PHACTR1 0.53 6.48 0.34 3.4e-10 Blood pressure; CRC cis rs7937682 0.883 rs472465 chr11:111468962 C/T cg09085632 chr11:111637200 PPP2R1B -0.94 -17.74 -0.7 7.01e-50 Primary sclerosing cholangitis; CRC cis rs17824933 1.000 rs916813 chr11:60764028 A/G cg16817237 chr11:60793675 NA 0.38 5.67 0.3 3.09e-8 Multiple sclerosis; CRC cis rs919433 0.889 rs12693816 chr2:198208420 T/A cg10820045 chr2:198174542 NA -0.5 -8.7 -0.43 1.59e-16 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC cis rs35110281 0.713 rs6518310 chr21:45098670 T/A cg21573476 chr21:45109991 RRP1B -0.37 -5.69 -0.3 2.88e-8 Mean corpuscular volume; CRC cis rs2576037 0.796 rs2571031 chr18:44577063 T/C cg20875182 chr18:44561130 TCEB3B;KATNAL2 -0.46 -7.3 -0.37 2.14e-12 Personality dimensions; CRC cis rs736408 0.609 rs62255396 chr3:52782839 C/T cg18099408 chr3:52552593 STAB1 -0.44 -7.16 -0.37 5.34e-12 Bipolar disorder; CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg03052632 chr12:57634626 NDUFA4L2 -0.52 -6.38 -0.33 6.13e-10 Diisocyanate-induced asthma; CRC cis rs9549367 0.713 rs556990 chr13:113845059 T/C cg24300038 chr13:113819356 PROZ 0.51 6.69 0.35 9.53e-11 Platelet distribution width; CRC cis rs11155671 0.530 rs4870080 chr6:150202644 T/C cg07701084 chr6:150067640 NUP43 0.47 6.69 0.35 9.5e-11 Testicular germ cell tumor; CRC cis rs76025697 1 rs76025697 chr5:179184488 G/A cg14593053 chr5:179126677 CANX 0.51 8.24 0.41 4.26e-15 Granulocyte percentage of myeloid white cells;Sum basophil neutrophil counts;Sum neutrophil eosinophil counts;Neutrophil count;Granulocyte count; CRC cis rs13191362 1.000 rs34344906 chr6:162993378 T/C cg21926612 chr6:163149169 PACRG;PARK2 0.82 11.49 0.54 6.51e-26 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs17767392 0.846 rs34911660 chr14:71752344 C/T cg13720639 chr14:72061746 SIPA1L1 -0.44 -5.88 -0.31 1.01e-8 Mitral valve prolapse; CRC cis rs8060686 0.920 rs112894876 chr16:67812039 G/C cg07125278 chr16:67683757 RLTPR -0.63 -6.85 -0.35 3.56e-11 HDL cholesterol;Metabolic syndrome; CRC cis rs34233420 1 rs34233420 chr17:38004929 GATTT/G cg00129232 chr17:37814104 STARD3 -0.45 -7.24 -0.37 3.13e-12 Lymphocyte counts; CRC cis rs1348850 0.915 rs10930798 chr2:178446141 G/A cg02961200 chr2:178257176 LOC100130691;AGPS 0.49 7.19 0.37 4.39e-12 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC trans rs60752752 0.852 rs4355996 chr1:153371601 A/G cg26481896 chr16:69975405 WWP2 0.51 6.26 0.33 1.21e-9 Monocyte percentage of white cells;Granulocyte percentage of myeloid white cells; CRC cis rs7618915 0.570 rs11130312 chr3:52675055 A/C cg11645453 chr3:52864694 ITIH4 0.36 6.25 0.33 1.29e-9 Bipolar disorder; CRC cis rs10464366 0.571 rs4723825 chr7:39157627 G/C cg18850127 chr7:39170497 POU6F2 0.58 7.65 0.39 2.27e-13 IgG glycosylation; CRC trans rs925098 0.577 rs2724470 chr4:17996046 A/G cg08045063 chr3:43147672 C3orf39 -0.42 -5.97 -0.31 6.01e-9 Birth weight;Height; CRC cis rs7208859 0.673 rs73263776 chr17:29211331 G/C cg13385521 chr17:29058706 SUZ12P 0.68 8.02 0.4 1.83e-14 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs651907 0.557 rs13081846 chr3:101383321 T/C cg12386194 chr3:101231763 SENP7 0.49 7.11 0.36 7.34e-12 Colorectal cancer; CRC cis rs951366 0.764 rs708725 chr1:205744138 G/T cg14159672 chr1:205819179 PM20D1 0.74 10.97 0.52 4.67e-24 Menarche (age at onset); CRC cis rs826838 0.510 rs10876149 chr12:39228083 C/G cg26384229 chr12:38710491 ALG10B -0.54 -6.83 -0.35 4.01e-11 Heart rate; CRC cis rs59918340 0.764 rs4961339 chr8:142231504 A/G cg23750338 chr8:142222470 SLC45A4 0.61 11.22 0.53 5.88e-25 Immature fraction of reticulocytes; CRC cis rs10197940 0.648 rs7587301 chr2:152347600 A/G cg19508488 chr2:152266495 RIF1 0.45 6.34 0.33 7.77e-10 Lung cancer; CRC cis rs2811415 0.597 rs9814461 chr3:127792309 G/A cg13719885 chr3:127795394 NA -0.39 -5.86 -0.31 1.12e-8 Lung function (FEV1/FVC); CRC cis rs9488822 0.702 rs6909746 chr6:116352750 C/T cg18764771 chr6:116381957 FRK 0.26 7.41 0.38 1.08e-12 Cholesterol, total;LDL cholesterol; CRC cis rs7811142 1.000 rs73161762 chr7:100014846 C/T cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.73 9.47 0.46 5.84e-19 Platelet count; CRC cis rs651907 0.557 rs7651406 chr3:101393296 C/T cg12386194 chr3:101231763 SENP7 0.47 6.78 0.35 5.53e-11 Colorectal cancer; CRC cis rs3008870 1.000 rs12039172 chr1:67447450 A/G cg08660285 chr1:67390436 MIER1;WDR78 -1.03 -14.98 -0.64 4.69e-39 Lymphocyte percentage of white cells; CRC cis rs853679 0.517 rs4713143 chr6:28106759 A/C cg03623178 chr6:28175578 NA 0.96 12.57 0.57 7.23e-30 Depression; CRC cis rs668210 0.739 rs543952 chr11:65744275 T/C cg02202077 chr11:65769826 EIF1AD;BANF1 0.49 6.35 0.33 6.97e-10 Cerebrospinal fluid biomarker levels; CRC cis rs7945705 0.520 rs1984791 chr11:9035027 C/T cg14711859 chr11:8959438 ASCL3 -0.42 -6.28 -0.33 1.07e-9 Hemoglobin concentration; CRC cis rs1799949 1.000 rs4793190 chr17:41200109 T/C cg19454999 chr17:41278357 BRCA1;NBR2 0.54 8.53 0.43 5.37e-16 Menopause (age at onset); CRC cis rs9916302 0.904 rs602282 chr17:37433021 C/T cg00129232 chr17:37814104 STARD3 -0.55 -8.15 -0.41 7.44e-15 Glomerular filtration rate (creatinine); CRC cis rs7917772 0.582 rs4917975 chr10:104358407 C/G cg11453585 chr10:104263688 ACTR1A;SUFU 0.82 15.29 0.64 3.12e-40 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC cis rs763121 0.813 rs4821807 chr22:39065582 A/G cg06544989 chr22:39130855 UNC84B 0.47 7.29 0.37 2.34e-12 Menopause (age at onset); CRC cis rs13082711 0.595 rs7615321 chr3:27368010 A/G cg02860705 chr3:27208620 NA 0.9 11.57 0.54 3.2e-26 Systolic blood pressure;Diastolic blood pressure;Blood pressure; CRC cis rs921968 0.541 rs72965126 chr2:219330189 C/T cg02176678 chr2:219576539 TTLL4 -0.57 -9.18 -0.45 4.97e-18 Mean corpuscular hemoglobin concentration; CRC cis rs7811142 1.000 rs11769700 chr7:100090049 T/C cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.08 15.21 0.64 6.34e-40 Platelet count; CRC cis rs7412746 0.658 rs59024312 chr1:150909005 T/G cg10589385 chr1:150898437 SETDB1 0.32 6.83 0.35 4.05e-11 Melanoma; CRC trans rs1005277 0.505 rs7917943 chr10:38195811 T/A cg17830980 chr10:43048298 ZNF37B 0.4 6.33 0.33 8.15e-10 Extrinsic epigenetic age acceleration; CRC cis rs7119 0.717 rs12901338 chr15:77804900 T/A cg27398640 chr15:77910606 LINGO1 -0.46 -7.98 -0.4 2.48e-14 Type 2 diabetes; CRC cis rs9398803 0.865 rs9398810 chr6:126815604 C/A cg19875578 chr6:126661172 C6orf173 0.43 6.12 0.32 2.67e-9 Male-pattern baldness; CRC cis rs3126085 0.877 rs12133847 chr1:152170101 T/G cg09127314 chr1:152161683 NA 0.49 6.31 0.33 8.78e-10 Atopic dermatitis; CRC cis rs13082711 0.871 rs7624790 chr3:27468601 C/A cg02860705 chr3:27208620 NA 0.59 8.58 0.43 3.87e-16 Systolic blood pressure;Diastolic blood pressure;Blood pressure; CRC cis rs11123610 0.520 rs7576701 chr2:3718227 T/C cg10645314 chr2:3704589 ALLC -0.55 -6.45 -0.34 4.02e-10 Response to inhaled corticosteroid treatment in asthma (change in FEV1); CRC cis rs10504229 0.683 rs67035623 chr8:58139963 G/T cg24829409 chr8:58192753 C8orf71 -0.55 -8.03 -0.4 1.71e-14 Developmental language disorder (linguistic errors); CRC cis rs6500602 0.964 rs13335685 chr16:4469284 T/C cg14951292 chr16:4525986 HMOX2;NMRAL1 0.52 7.42 0.38 1e-12 Schizophrenia; CRC cis rs12325245 0.536 rs35832551 chr16:58591444 G/T cg26666090 chr16:58549219 SETD6 0.92 6.25 0.33 1.26e-9 Schizophrenia; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg05318427 chr2:85199320 KCMF1 0.49 6.41 0.33 5e-10 Thyroid stimulating hormone; CRC cis rs10979 0.965 rs9390111 chr6:143894272 T/C cg25407410 chr6:143891975 LOC285740 -0.83 -13.73 -0.6 3.07e-34 Hypospadias; CRC cis rs12928939 0.636 rs11639902 chr16:71755852 C/T cg08717414 chr16:71523259 ZNF19 0.41 5.77 0.3 1.78e-8 Post bronchodilator FEV1; CRC cis rs875971 1.000 rs6979382 chr7:65886375 C/T cg18876405 chr7:65276391 NA 0.51 8.76 0.43 1.07e-16 Aortic root size; CRC trans rs7267979 1.000 rs6050562 chr20:25336186 C/G cg17903999 chr18:56338584 MALT1 0.41 6.79 0.35 5.18e-11 Liver enzyme levels (alkaline phosphatase); CRC cis rs920590 0.684 rs59259846 chr8:19669468 C/G cg03894339 chr8:19674705 INTS10 0.42 5.78 0.3 1.72e-8 Acute lymphoblastic leukemia (childhood); CRC cis rs4629180 0.544 rs7595274 chr2:102140086 T/C cg01388757 chr2:102091195 RFX8 -0.35 -5.64 -0.3 3.7e-8 Chronic rhinosinusitis with nasal polyps; CRC cis rs7312933 0.703 rs12371615 chr12:42563989 C/G cg19980929 chr12:42632907 YAF2 0.45 6.69 0.35 9.4e-11 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CRC cis rs875971 0.825 rs801202 chr7:66023929 C/T cg11764359 chr7:65958608 NA -0.58 -8.7 -0.43 1.62e-16 Aortic root size; CRC cis rs9858542 0.537 rs34915642 chr3:49358646 G/A cg00383909 chr3:49044727 WDR6 0.67 7.37 0.38 1.4e-12 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs10504229 0.593 rs17794451 chr8:58019217 C/T cg02290350 chr8:58132656 NA -0.51 -5.89 -0.31 9.42e-9 Developmental language disorder (linguistic errors); CRC trans rs2727020 0.595 rs10769583 chr11:49483193 G/A cg11707556 chr5:10655725 ANKRD33B -0.4 -7.58 -0.39 3.59e-13 Coronary artery disease; CRC cis rs7630877 0.719 rs12489992 chr3:179664925 A/C cg18765712 chr3:179670323 PEX5L 0.49 6.91 0.36 2.46e-11 Type 2 diabetes; CRC cis rs4713118 0.955 rs9368529 chr6:27684631 G/A cg19041857 chr6:27730383 NA -0.42 -5.87 -0.31 1.05e-8 Parkinson's disease; CRC cis rs1003719 0.788 rs9981226 chr21:38452127 C/T cg10648535 chr21:38446584 PIGP;TTC3 0.53 7.45 0.38 8.49e-13 Eye color traits; CRC cis rs344364 0.511 rs1742460 chr16:1945441 G/C cg00046913 chr16:1877150 HAGH;FAHD1 -0.62 -6.15 -0.32 2.19e-9 Glomerular filtration rate in chronic kidney disease; CRC cis rs10791323 0.569 rs5019134 chr11:133713082 G/C cg06766960 chr11:133703094 NA -0.35 -5.87 -0.31 1.06e-8 Childhood ear infection; CRC cis rs2070488 0.804 rs2268755 chr3:38501916 A/G cg01465620 chr3:38496096 LOC100128640;ACVR2B -0.75 -12.56 -0.57 7.72e-30 Electrocardiographic conduction measures; CRC cis rs28386778 0.830 rs2665798 chr17:61921397 C/T cg07362569 chr17:61921086 SMARCD2 0.38 5.83 0.31 1.3e-8 Prudent dietary pattern; CRC cis rs6460942 0.915 rs6460907 chr7:12304449 G/A cg06484146 chr7:12443880 VWDE -0.52 -6.92 -0.36 2.4e-11 Coronary artery disease; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg01671314 chr6:135502610 MYB 0.36 5.97 0.31 6.05e-9 Liver disease severity in Alagille syndrome; CRC cis rs11148252 0.716 rs3803262 chr13:53036398 A/G cg12458913 chr13:53173898 NA 0.56 8.69 0.43 1.71e-16 Lewy body disease; CRC cis rs4332037 0.539 rs55988458 chr7:2059761 G/A cg21155852 chr7:2048760 MAD1L1 -0.49 -6.63 -0.34 1.35e-10 Bipolar disorder; CRC cis rs2153535 0.541 rs1414353 chr6:8485642 C/G cg21535247 chr6:8435926 SLC35B3 0.5 7.54 0.38 4.72e-13 Motion sickness; CRC cis rs9891119 0.550 rs12601611 chr17:40497828 C/T cg06270615 chr17:40516068 STAT3 -0.35 -7.49 -0.38 6.22e-13 Multiple sclerosis;Crohn's disease; CRC cis rs17376456 0.825 rs10056879 chr5:93282218 C/A cg21475434 chr5:93447410 FAM172A 0.81 7.6 0.39 3.07e-13 Diabetic retinopathy; CRC cis rs9905704 0.918 rs68139131 chr17:56717249 A/G cg12560992 chr17:57184187 TRIM37 0.56 7.63 0.39 2.5e-13 Testicular germ cell tumor; CRC cis rs2576037 0.526 rs10853545 chr18:44475220 A/T cg23996704 chr18:44553084 KATNAL2 -0.33 -6.72 -0.35 8.02e-11 Personality dimensions; CRC cis rs7772486 0.743 rs9390344 chr6:146012755 C/G cg23711669 chr6:146136114 FBXO30 -0.66 -11.01 -0.52 3.15e-24 Lobe attachment (rater-scored or self-reported); CRC cis rs9323205 0.862 rs11629399 chr14:51612814 T/C cg23942311 chr14:51606299 NA -0.58 -7.13 -0.37 6.53e-12 Cancer; CRC cis rs9916302 0.904 rs588193 chr17:37440439 A/C cg03013999 chr17:37608204 MED1 -0.5 -7.7 -0.39 1.61e-13 Glomerular filtration rate (creatinine); CRC cis rs1728785 1.000 rs1749792 chr16:68569440 T/G cg02972257 chr16:68554789 NA -0.58 -7.15 -0.37 5.78e-12 Ulcerative colitis; CRC cis rs9303401 0.659 rs34556735 chr17:56694447 A/C cg02118635 chr17:56770003 RAD51C;TEX14 0.82 9.7 0.47 9.61e-20 Cognitive test performance; CRC cis rs7224737 1.000 rs9903204 chr17:40288062 G/A cg02450064 chr17:40260053 DHX58 -0.42 -6.11 -0.32 2.75e-9 Fibrinogen levels; CRC cis rs2243480 1.000 rs56291018 chr7:65390339 G/A cg25985355 chr7:65971099 NA -0.48 -5.65 -0.3 3.53e-8 Diabetic kidney disease; CRC cis rs909002 0.800 rs1056526 chr1:32084904 C/T cg01639898 chr1:32083012 HCRTR1 0.3 6.1 0.32 2.95e-9 Intelligence (multi-trait analysis); CRC trans rs7829975 0.501 rs2980769 chr8:8320291 G/A cg16141378 chr3:129829833 LOC729375 -0.48 -7.29 -0.37 2.37e-12 Mood instability; CRC cis rs2797685 1.000 rs707466 chr1:7861600 C/A cg04725166 chr1:7887271 PER3 -0.47 -5.97 -0.31 6.29e-9 Crohn's disease; CRC cis rs12681288 0.644 rs2123058 chr8:1000304 A/G cg04851639 chr8:1020857 NA -0.39 -7.81 -0.4 7.49e-14 Schizophrenia; CRC cis rs365302 1.000 rs418901 chr6:159648869 T/A cg14500486 chr6:159655392 FNDC1 0.44 6.87 0.35 3.15e-11 Coronary heart disease; CRC cis rs9322193 0.962 rs9688750 chr6:149978769 T/C cg07701084 chr6:150067640 NUP43 0.47 6.68 0.35 1.03e-10 Lung cancer; CRC trans rs8073060 0.821 rs11080355 chr17:33872694 T/A cg19694781 chr19:47549865 TMEM160 0.58 8.23 0.41 4.44e-15 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; CRC cis rs11098499 0.826 rs12511640 chr4:120251248 T/C cg09307838 chr4:120376055 NA 0.61 9.59 0.47 2.22e-19 Corneal astigmatism; CRC cis rs4713118 0.715 rs200480 chr6:27773664 A/G cg03623178 chr6:28175578 NA 0.6 8.38 0.42 1.57e-15 Parkinson's disease; CRC cis rs977987 0.835 rs7200616 chr16:75366089 G/A cg03315344 chr16:75512273 CHST6 0.52 8.78 0.44 8.79e-17 Dupuytren's disease; CRC cis rs595982 0.527 rs17206707 chr19:49361441 A/C cg15549821 chr19:49342101 PLEKHA4 -0.54 -6.31 -0.33 8.93e-10 Red cell distribution width; CRC cis rs1801251 0.711 rs2592117 chr2:233735693 C/T cg25237894 chr2:233734115 C2orf82 -0.63 -11.02 -0.52 2.9e-24 Coronary artery disease; CRC cis rs798554 0.679 rs1636253 chr7:2885123 A/G cg19717773 chr7:2847554 GNA12 -0.43 -6.11 -0.32 2.82e-9 Height; CRC cis rs7777484 0.500 rs757787 chr7:2836355 G/A cg09658497 chr7:2847517 GNA12 -0.36 -5.97 -0.31 6.15e-9 Height; CRC cis rs601339 1.000 rs35683065 chr12:123164062 G/C cg25190513 chr12:123201362 GPR109B -0.49 -6.06 -0.32 3.65e-9 Adiponectin levels; CRC cis rs1997103 0.954 rs10246216 chr7:55390479 C/T cg17469321 chr7:55412551 NA 0.74 11.48 0.53 7.1e-26 QRS interval (sulfonylurea treatment interaction); CRC cis rs561341 0.882 rs563539 chr17:30307958 A/G cg12193833 chr17:30244370 NA -0.63 -8.27 -0.41 3.34e-15 Hip circumference adjusted for BMI; CRC cis rs12760731 0.623 rs10913549 chr1:178383657 C/G cg00404053 chr1:178313656 RASAL2 0.76 9.53 0.47 3.62e-19 Obesity-related traits; CRC cis rs17401966 0.597 rs11121526 chr1:10251082 G/A cg19773385 chr1:10388646 KIF1B -0.53 -8.11 -0.41 1.02e-14 Hepatocellular carcinoma; CRC cis rs6952808 0.609 rs4721185 chr7:1951109 T/C cg22963979 chr7:1858916 MAD1L1 -0.43 -6.86 -0.35 3.36e-11 Bipolar disorder and schizophrenia; CRC cis rs7647973 0.516 rs4536858 chr3:49193081 A/G cg07636037 chr3:49044803 WDR6 0.84 12.79 0.58 1.09e-30 Menarche (age at onset); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg11318307 chr19:9695355 ZNF121 0.44 6.45 0.34 4.1e-10 Intelligence (multi-trait analysis); CRC cis rs2730260 0.537 rs56260213 chr7:158875921 C/T cg02254261 chr7:158964346 NA -0.54 -6.07 -0.32 3.6e-9 Myopia (pathological); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg13791713 chr21:40720916 HMGN1 0.44 6.59 0.34 1.73e-10 Intelligence (multi-trait analysis); CRC cis rs2952156 0.920 rs2517951 chr17:37853097 C/T cg15445000 chr17:37608096 MED1 0.26 5.76 0.3 1.93e-8 Asthma; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg17404403 chr4:110737017 GAR1 0.38 6.03 0.32 4.38e-9 Liver disease severity in Alagille syndrome; CRC trans rs2303319 0.504 rs62189042 chr2:162602320 G/T cg22988483 chr14:93581567 ITPK1 -0.66 -6.07 -0.32 3.52e-9 Cognitive function; CRC cis rs9747201 1.000 rs9747201 chr17:80177852 A/C cg14673194 chr17:80132900 CCDC57 -0.46 -5.97 -0.31 6.04e-9 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs7119 0.717 rs8040702 chr15:77803615 G/A cg27398640 chr15:77910606 LINGO1 -0.47 -8.08 -0.41 1.21e-14 Type 2 diabetes; CRC cis rs17711722 0.727 rs781151 chr7:65479878 T/C cg00343986 chr7:65444356 GUSB 0.53 7.66 0.39 2.12e-13 Calcium levels; CRC cis rs853679 0.517 rs9368554 chr6:28082711 T/C cg02631126 chr6:28058918 ZSCAN12L1 0.29 5.87 0.31 1.05e-8 Depression; CRC cis rs11098499 1.000 rs12506395 chr4:120185094 C/T cg24375607 chr4:120327624 NA 0.43 6.59 0.34 1.72e-10 Corneal astigmatism; CRC cis rs4713118 0.824 rs9468229 chr6:27750086 G/A cg06470822 chr6:28175283 NA 0.74 10.0 0.48 9.56e-21 Parkinson's disease; CRC trans rs1005277 0.528 rs2057228 chr10:38515766 T/C cg27523141 chr10:43048294 ZNF37B 0.47 6.9 0.36 2.69e-11 Extrinsic epigenetic age acceleration; CRC cis rs2933343 0.729 rs789228 chr3:128601050 A/G cg11901034 chr3:128598214 ACAD9 -0.54 -7.69 -0.39 1.74e-13 IgG glycosylation; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg20480041 chr5:72251406 FCHO2 0.43 6.19 0.32 1.74e-9 Response to antipsychotic treatment; CRC cis rs6460942 1.000 rs17274870 chr7:12406221 G/T cg20607287 chr7:12443886 VWDE -0.64 -6.73 -0.35 7.75e-11 Coronary artery disease; CRC cis rs2721195 0.654 rs4610795 chr8:145881333 C/T cg26752003 chr8:145688521 CYHR1 0.38 6.09 0.32 3.21e-9 Age at first birth; CRC cis rs10256972 0.567 rs2949185 chr7:1209013 A/G cg07092213 chr7:1199455 ZFAND2A -0.48 -6.92 -0.36 2.41e-11 Longevity;Endometriosis; CRC cis rs853679 0.517 rs3757185 chr6:28107776 T/A cg15845792 chr6:28175446 NA 1.01 13.54 0.6 1.59e-33 Depression; CRC cis rs10992471 0.603 rs1535755 chr9:95202031 G/T cg14631576 chr9:95140430 CENPP -0.4 -7.13 -0.37 6.48e-12 Visceral adipose tissue/subcutaneous adipose tissue ratio; CRC trans rs853679 1.000 rs6905391 chr6:28262686 G/A cg06606381 chr12:133084897 FBRSL1 -0.62 -6.34 -0.33 7.65e-10 Depression; CRC cis rs4237845 0.804 rs11172372 chr12:58286273 T/C cg00677455 chr12:58241039 CTDSP2 0.51 7.41 0.38 1.05e-12 Intelligence (multi-trait analysis); CRC cis rs1816752 0.805 rs61614647 chr13:25015967 C/T cg02811702 chr13:24901961 NA 0.48 6.66 0.34 1.14e-10 Obesity-related traits; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg04514556 chr3:71113948 FOXP1 0.44 6.27 0.33 1.11e-9 Intelligence (multi-trait analysis); CRC cis rs798554 1.000 rs798544 chr7:2763102 A/G cg19346786 chr7:2764209 NA 0.42 7.68 0.39 1.84e-13 Height; CRC cis rs477895 1.000 rs7938380 chr11:64034866 G/A cg23719950 chr11:63933701 MACROD1 -0.55 -5.89 -0.31 9.3e-9 Mean platelet volume; CRC cis rs9837602 0.529 rs793459 chr3:99520591 G/A cg07805332 chr3:99536008 MIR548G;C3orf26 0.52 7.75 0.39 1.12e-13 Breast cancer; CRC cis rs4555082 0.874 rs2015978 chr14:105720134 G/C cg06808227 chr14:105710500 BRF1 -0.62 -8.95 -0.44 2.6e-17 Mean platelet volume;Platelet distribution width; CRC cis rs2933343 0.951 rs796862 chr3:128593040 G/A cg11901034 chr3:128598214 ACAD9 -0.51 -6.23 -0.32 1.43e-9 IgG glycosylation; CRC cis rs6684514 1.000 rs12132794 chr1:156281020 C/G cg16558208 chr1:156270281 VHLL -0.57 -8.92 -0.44 3.34e-17 Mean corpuscular hemoglobin concentration;Glycated hemoglobin levels; CRC cis rs10992471 0.528 rs4744133 chr9:95226702 C/T cg14631576 chr9:95140430 CENPP -0.32 -5.85 -0.31 1.19e-8 Visceral adipose tissue/subcutaneous adipose tissue ratio; CRC cis rs9457247 1.000 rs430293 chr6:167404958 A/G cg23791538 chr6:167370224 RNASET2 -0.38 -5.94 -0.31 7.32e-9 Crohn's disease; CRC trans rs208520 0.874 rs208515 chr6:66945749 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.92 -11.93 -0.55 1.6e-27 Exhaled nitric oxide output; CRC cis rs12692738 0.526 rs355875 chr2:165632755 G/A cg03182029 chr2:165697222 COBLL1 0.5 5.86 0.31 1.11e-8 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);Waist-to-hip ratio adjusted for BMI in non-smokers;Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction);Waist-to-hip ratio adjusted for body mass index; CRC cis rs7192750 0.652 rs150617 chr16:72139396 T/C cg14768367 chr16:72042858 DHODH 0.76 6.02 0.32 4.62e-9 LDL cholesterol levels;Total cholesterol levels; CRC cis rs6815814 0.950 rs67719080 chr4:38787252 A/G cg06935464 chr4:38784597 TLR10 0.65 7.42 0.38 9.87e-13 Breast cancer; CRC cis rs2204008 0.540 rs1672425 chr12:38122842 G/A cg26384229 chr12:38710491 ALG10B -0.56 -8.38 -0.42 1.58e-15 Bladder cancer; CRC cis rs9905704 0.918 rs654743 chr17:56736490 T/C cg12560992 chr17:57184187 TRIM37 0.56 7.63 0.39 2.5e-13 Testicular germ cell tumor; CRC cis rs3849570 1.000 rs78242412 chr3:81747219 A/G cg07356753 chr3:81810745 GBE1 -0.76 -11.51 -0.54 5.36e-26 Waist circumference;Body mass index; CRC cis rs367943 1.000 rs348962 chr5:112819086 C/T cg12552261 chr5:112820674 MCC 0.48 7.42 0.38 9.9e-13 Type 2 diabetes; CRC trans rs9858542 0.951 rs1800668 chr3:49395757 G/A cg21665057 chr3:196295764 WDR53;FBXO45 -0.62 -8.52 -0.43 5.85e-16 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs13315871 0.929 rs71311854 chr3:58319159 G/A cg20936604 chr3:58311152 NA -0.77 -7.16 -0.37 5.29e-12 Cholesterol, total; CRC cis rs28374715 0.681 rs77187862 chr15:41619276 A/T cg18705301 chr15:41695430 NDUFAF1 -0.85 -13.66 -0.6 5.67e-34 Ulcerative colitis; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg02222290 chr10:72575603 SGPL1 0.47 6.34 0.33 7.43e-10 Anxiety disorder; CRC cis rs6912958 0.712 rs4707383 chr6:88330602 T/A cg08069147 chr6:88032118 GJB7;C6orf162 -0.57 -8.61 -0.43 3.14e-16 Monocyte percentage of white cells; CRC cis rs7927771 0.542 rs6485775 chr11:47773518 A/G cg20307385 chr11:47447363 PSMC3 -0.46 -6.76 -0.35 6.25e-11 Subjective well-being; CRC cis rs1559088 0.522 rs7254912 chr19:33554151 A/G cg17764715 chr19:33622953 WDR88 0.43 6.33 0.33 8.25e-10 Bone ultrasound measurement (broadband ultrasound attenuation); CRC cis rs1046896 0.739 rs28459016 chr17:80741194 G/A cg16060761 chr17:80687452 NA -0.46 -6.14 -0.32 2.41e-9 Glycated hemoglobin levels; CRC trans rs6076960 0.684 rs6038408 chr20:6268983 A/C cg21095983 chr6:86352623 SYNCRIP 0.58 8.19 0.41 5.94e-15 Smooth-surface caries; CRC cis rs2836974 0.627 rs8127986 chr21:40687211 A/T cg06238570 chr21:40685208 BRWD1 -0.79 -12.62 -0.57 4.67e-30 Cognitive function; CRC trans rs35110281 0.782 rs2329442 chr21:45041790 T/C cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.5 8.28 0.42 3.2e-15 Mean corpuscular volume; CRC cis rs7188861 0.603 rs2113260 chr16:11455993 C/T cg00044050 chr16:11439710 C16orf75 0.41 5.62 0.3 4.04e-8 HDL cholesterol; CRC cis rs7772486 0.754 rs9386133 chr6:146141213 A/G cg23711669 chr6:146136114 FBXO30 0.66 10.97 0.52 4.63e-24 Lobe attachment (rater-scored or self-reported); CRC cis rs7202877 0.611 rs56092808 chr16:75312716 A/T cg03315344 chr16:75512273 CHST6 0.52 5.88 0.31 1.02e-8 Type 2 diabetes;Type 1 diabetes; CRC cis rs7089973 0.872 rs17092542 chr10:116630289 G/A cg03647239 chr10:116582469 FAM160B1 0.41 5.81 0.31 1.48e-8 Bipolar disorder or attention deficit hyperactivity disorder; CRC cis rs67311347 1.000 rs28434528 chr3:40484893 A/G cg24209194 chr3:40518798 ZNF619 0.42 6.33 0.33 8.25e-10 Renal cell carcinoma; CRC cis rs7666738 0.830 rs1426672 chr4:98923984 T/C cg17366294 chr4:99064904 C4orf37 0.43 7.32 0.37 1.95e-12 Colonoscopy-negative controls vs population controls; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg22303773 chr11:65030031 POLA2 0.45 6.41 0.33 5.08e-10 Response to antipsychotic treatment; CRC cis rs709400 0.663 rs7145113 chr14:103945414 A/G cg12935359 chr14:103987150 CKB -0.51 -8.01 -0.4 2.06e-14 Body mass index; CRC cis rs6088590 1.000 rs6087626 chr20:33347328 C/T cg24642439 chr20:33292090 TP53INP2 0.6 10.96 0.52 4.76e-24 Coronary artery disease; CRC cis rs3026101 0.587 rs8066000 chr17:5310033 C/G cg25236894 chr17:5323110 RPAIN;NUP88 0.42 6.9 0.36 2.74e-11 Body mass index; CRC cis rs4319547 0.656 rs10773075 chr12:122814236 G/A cg05707623 chr12:122985044 ZCCHC8 -0.68 -8.36 -0.42 1.85e-15 Body mass index; CRC trans rs116095464 0.558 rs10052012 chr5:231908 T/C cg00938859 chr5:1591904 SDHAP3 0.69 7.58 0.39 3.49e-13 Breast cancer; CRC cis rs1867631 1.000 rs7546090 chr1:67083981 G/A cg02459107 chr1:67143332 SGIP1 0.34 5.75 0.3 2.06e-8 Menopause (age at onset); CRC cis rs7917772 0.636 rs7079231 chr10:104527341 A/G cg22532475 chr10:104410764 TRIM8 -0.33 -5.69 -0.3 2.86e-8 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC cis rs733592 0.524 rs10875741 chr12:48492922 A/C cg24011408 chr12:48396354 COL2A1 -0.45 -6.68 -0.35 1.02e-10 Plateletcrit; CRC cis rs7618915 0.547 rs34537256 chr3:52657472 A/G cg07507251 chr3:52567010 NT5DC2 0.46 6.68 0.35 1.01e-10 Bipolar disorder; CRC cis rs908922 0.605 rs3753448 chr1:152486407 A/C cg23254163 chr1:152506842 NA 0.45 8.9 0.44 3.87e-17 Hair morphology; CRC trans rs12940923 1.000 rs12452417 chr17:56367202 G/A cg16900910 chr15:72789182 ARIH1 0.52 5.97 0.31 6.14e-9 Circulating myeloperoxidase levels (plasma); CRC cis rs7208859 0.623 rs9916727 chr17:29107472 A/G cg13385521 chr17:29058706 SUZ12P 0.73 8.4 0.42 1.39e-15 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs7107174 1.000 rs2256464 chr11:77917305 C/A cg02023728 chr11:77925099 USP35 0.43 6.93 0.36 2.21e-11 Testicular germ cell tumor; CRC cis rs2777491 0.507 rs34040639 chr15:41760807 A/G cg18705301 chr15:41695430 NDUFAF1 -1.1 -19.6 -0.73 3.26e-57 Ulcerative colitis; CRC cis rs3820068 0.603 rs72645887 chr1:15929905 G/C cg27534772 chr1:16042836 PLEKHM2 0.54 10.46 0.5 2.7e-22 Systolic blood pressure; CRC cis rs1862618 0.853 rs252922 chr5:56136343 G/T cg03609598 chr5:56110824 MAP3K1 -0.82 -10.15 -0.49 2.98e-21 Initial pursuit acceleration; CRC cis rs10751667 0.643 rs10902257 chr11:973577 T/C cg06064525 chr11:970664 AP2A2 -0.3 -6.1 -0.32 3.06e-9 Alzheimer's disease (late onset); CRC cis rs875971 1.000 rs1544549 chr7:66090663 T/A cg12463550 chr7:65579703 CRCP -0.47 -6.52 -0.34 2.71e-10 Aortic root size; CRC cis rs10504229 0.683 rs67035623 chr8:58139963 G/T cg22535103 chr8:58192502 C8orf71 -0.7 -9.34 -0.46 1.47e-18 Developmental language disorder (linguistic errors); CRC cis rs6860806 0.695 rs6867282 chr5:131583120 G/C cg20512303 chr5:131592959 PDLIM4 0.36 6.85 0.35 3.59e-11 Breast cancer; CRC cis rs9807841 0.568 rs1560708 chr19:10749236 T/C cg17710535 chr19:10819994 QTRT1 0.42 5.83 0.31 1.35e-8 Inflammatory skin disease; CRC cis rs9372498 0.505 rs17427284 chr6:118991953 A/T cg01339444 chr6:118972232 C6orf204 0.58 6.17 0.32 2.02e-9 Diastolic blood pressure; CRC cis rs501120 0.778 rs523297 chr10:44756557 C/T cg09554077 chr10:44749378 NA 0.66 7.47 0.38 7.42e-13 Coronary artery disease;Coronary heart disease; CRC cis rs6500395 1.000 rs11649236 chr16:48632478 C/T cg04672837 chr16:48644449 N4BP1 0.45 6.75 0.35 6.7e-11 Response to tocilizumab in rheumatoid arthritis; CRC trans rs61931739 0.517 rs11612493 chr12:34114272 A/C cg26384229 chr12:38710491 ALG10B 0.53 6.99 0.36 1.53e-11 Morning vs. evening chronotype; CRC trans rs7613875 0.543 rs34034116 chr3:49959156 C/A cg21665057 chr3:196295764 WDR53;FBXO45 0.45 6.42 0.33 4.71e-10 Body mass index; CRC cis rs172166 0.516 rs2622322 chr6:28117443 C/G cg23161317 chr6:28129485 ZNF389 0.39 5.81 0.31 1.45e-8 Cardiac Troponin-T levels; CRC trans rs2055729 0.645 rs12544019 chr8:9742578 T/C cg06636001 chr8:8085503 FLJ10661 0.58 7.17 0.37 4.92e-12 Multiple myeloma (hyperdiploidy); CRC cis rs2692947 0.826 rs7423942 chr2:96645257 G/A cg23100626 chr2:96804247 ASTL 0.25 6.92 0.36 2.31e-11 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; CRC cis rs9818758 0.607 rs4855860 chr3:49526044 A/T cg07636037 chr3:49044803 WDR6 0.76 6.16 0.32 2.07e-9 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; CRC cis rs2439831 0.850 rs12441861 chr15:44060883 C/T cg02155558 chr15:43621948 ADAL;LCMT2 0.66 7.24 0.37 3.17e-12 Lung cancer in ever smokers; CRC cis rs10927875 0.541 rs1739842 chr1:16342848 T/G cg24140574 chr1:16342155 HSPB7 0.47 6.74 0.35 7.16e-11 Dilated cardiomyopathy; CRC cis rs1799949 1.000 rs1799966 chr17:41223094 T/C cg25072359 chr17:41440525 NA 0.47 7.04 0.36 1.15e-11 Menopause (age at onset); CRC cis rs10927875 0.894 rs34957618 chr1:16320499 G/C cg22431228 chr1:16359049 CLCNKA 0.37 6.6 0.34 1.65e-10 Dilated cardiomyopathy; CRC cis rs243505 0.732 rs3800949 chr7:148479648 A/T cg09806900 chr7:148480153 CUL1 -0.55 -8.09 -0.41 1.19e-14 Inflammatory bowel disease;Crohn's disease; CRC trans rs1814175 0.645 rs10839382 chr11:49823172 C/T cg03929089 chr4:120376271 NA -0.91 -15.6 -0.65 1.89e-41 Height; CRC cis rs853679 0.517 rs9380050 chr6:28048538 A/G cg23161317 chr6:28129485 ZNF389 0.52 6.4 0.33 5.21e-10 Depression; CRC cis rs2050392 0.630 rs303427 chr10:30739780 G/A cg25182066 chr10:30743637 MAP3K8 -0.5 -7.13 -0.37 6.3e-12 Inflammatory bowel disease; CRC cis rs1178968 0.818 rs6957049 chr7:72754037 G/A cg25889504 chr7:72793014 NA 0.5 5.79 0.3 1.67e-8 Triglyceride levels; CRC cis rs10193935 0.786 rs72796504 chr2:42406728 T/C cg27598129 chr2:42591480 NA -0.69 -7.87 -0.4 5.09e-14 Colonoscopy-negative controls vs population controls; CRC cis rs7618501 0.699 rs9821675 chr3:49902544 A/G cg24110177 chr3:50126178 RBM5 -0.46 -6.68 -0.35 1.03e-10 Intelligence (multi-trait analysis); CRC cis rs2404602 0.647 rs12913024 chr15:77145216 C/T cg23625390 chr15:77176239 SCAPER -0.85 -12.68 -0.57 2.91e-30 Blood metabolite levels; CRC cis rs6964587 0.967 rs2040499 chr7:91809657 C/G cg17063962 chr7:91808500 NA -0.83 -14.44 -0.62 5.72e-37 Breast cancer; CRC cis rs8180040 0.620 rs2305635 chr3:47043622 G/A cg02527881 chr3:46936655 PTH1R 0.33 5.7 0.3 2.67e-8 Colorectal cancer; CRC cis rs6502050 0.835 rs7503225 chr17:80099639 C/A cg13198984 chr17:80129470 CCDC57 0.46 8.16 0.41 6.94e-15 Life satisfaction; CRC cis rs2032447 0.869 rs199752 chr6:26012875 C/T cg12588279 chr6:26043732 HIST1H2BB 0.48 6.89 0.36 2.78e-11 Intelligence (multi-trait analysis); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg11586124 chr12:58259160 NA 0.43 7.29 0.37 2.39e-12 Liver disease severity in Alagille syndrome; CRC cis rs17711722 0.727 rs35850374 chr7:65357776 A/G cg11764359 chr7:65958608 NA 0.51 7.83 0.4 6.7e-14 Calcium levels; CRC cis rs11608355 0.521 rs6606703 chr12:109813665 C/T cg19025524 chr12:109796872 NA -0.57 -9.18 -0.45 4.89e-18 Neuroticism; CRC cis rs1005277 0.522 rs7072977 chr10:37940440 C/A cg25427524 chr10:38739819 LOC399744 -0.73 -12.15 -0.56 2.49e-28 Extrinsic epigenetic age acceleration; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg07025548 chr5:74632477 HMGCR 0.4 6.27 0.33 1.16e-9 Liver disease severity in Alagille syndrome; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg20503117 chr3:5164013 ARL8B 0.46 6.66 0.34 1.16e-10 Intelligence (multi-trait analysis); CRC cis rs40363 0.857 rs55989968 chr16:3530658 C/G cg00484396 chr16:3507460 NAT15 0.74 8.38 0.42 1.58e-15 Tuberculosis; CRC cis rs9409565 0.559 rs7044227 chr9:97067592 T/A cg04523069 chr9:97136363 HIATL1 -0.43 -6.0 -0.31 5.28e-9 Colorectal cancer (alcohol consumption interaction); CRC cis rs6741819 1.000 rs10929458 chr2:7147152 A/T cg27144453 chr2:7172511 RNF144A -0.42 -6.26 -0.33 1.23e-9 Response to antipsychotic treatment; CRC cis rs6860806 0.507 rs272891 chr5:131664394 G/T cg12564285 chr5:131593104 PDLIM4 0.44 7.46 0.38 8e-13 Breast cancer; CRC cis rs3785574 0.962 rs2727329 chr17:61924566 C/T cg22520471 chr17:61851767 DDX42;CCDC47 0.45 6.11 0.32 2.85e-9 Height; CRC cis rs9372498 0.505 rs17427284 chr6:118991953 A/T cg24463073 chr6:118973353 C6orf204 0.48 6.0 0.31 5.3300000000000004e-09 Diastolic blood pressure; CRC cis rs8067545 0.641 rs203481 chr17:19828728 C/T cg04132472 chr17:19861366 AKAP10 0.43 6.83 0.35 4.01e-11 Schizophrenia; CRC cis rs7172677 1.000 rs2029519 chr15:75415962 A/G cg14664628 chr15:75095509 CSK -0.49 -5.72 -0.3 2.34e-8 Systemic lupus erythematosus and Systemic sclerosis; CRC trans rs3733585 0.699 rs7686538 chr4:9948077 C/T cg26043149 chr18:55253948 FECH -0.46 -6.82 -0.35 4.27e-11 Cleft plate (environmental tobacco smoke interaction); CRC cis rs13108904 0.901 rs2293634 chr4:1291711 T/G cg23123621 chr4:1343375 KIAA1530 0.32 5.71 0.3 2.54e-8 Obesity-related traits; CRC cis rs9942416 0.660 rs2047059 chr5:75008193 T/C cg00601450 chr5:74908170 NA 0.39 6.01 0.31 5.03e-9 Age-related disease endophenotypes; CRC cis rs7487075 0.722 rs4768111 chr12:46705761 T/C cg22049899 chr12:47219821 SLC38A4 0.33 6.3 0.33 9.37e-10 Itch intensity from mosquito bite; CRC cis rs7552404 0.727 rs7547056 chr1:76279267 C/T cg22875332 chr1:76189707 ACADM 0.56 7.25 0.37 2.99e-12 Blood metabolite levels;Acylcarnitine levels; CRC cis rs9399137 0.507 rs6569986 chr6:135311641 T/C cg24558204 chr6:135376177 HBS1L 0.62 9.46 0.46 5.88e-19 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; CRC cis rs892961 0.932 rs11658267 chr17:75411884 C/T cg05865280 chr17:75406074 SEPT9 -0.63 -14.98 -0.64 4.93e-39 Airflow obstruction; CRC cis rs968567 1.000 rs968567 chr11:61595564 C/T cg25303599 chr11:61595807 FADS2 -0.45 -5.76 -0.3 1.9e-8 Blood metabolite levels;Rheumatoid arthritis;Vitiligo;Glycerophospholipid levels; CRC cis rs17767392 0.595 rs8005925 chr14:71661292 C/T cg13720639 chr14:72061746 SIPA1L1 -0.47 -6.0 -0.31 5.16e-9 Mitral valve prolapse; CRC cis rs67311347 1.000 rs73080126 chr3:40509153 A/G cg24209194 chr3:40518798 ZNF619 0.41 5.71 0.3 2.47e-8 Renal cell carcinoma; CRC cis rs6540556 0.521 rs1337531 chr1:209911988 T/G cg23920097 chr1:209922102 NA -0.48 -5.9 -0.31 8.87e-9 Red blood cell count; CRC cis rs7605827 0.930 rs10929365 chr2:15531626 G/A cg19274914 chr2:15703543 NA 0.39 5.84 0.31 1.25e-8 Educational attainment (years of education); CRC cis rs9443189 0.570 rs6903124 chr6:76290079 A/C cg01950844 chr6:76311363 SENP6 0.74 9.8 0.48 4.62e-20 Prostate cancer; CRC cis rs7811142 1.000 rs28490152 chr7:100020982 G/A cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.75 10.9 0.52 8.12e-24 Platelet count; CRC cis rs12497850 0.931 rs7616815 chr3:48779715 C/T cg07636037 chr3:49044803 WDR6 1.0 17.5 0.69 6.03e-49 Parkinson's disease; CRC cis rs6460942 1.000 rs2053378 chr7:12405564 C/G cg20607287 chr7:12443886 VWDE -0.64 -6.66 -0.34 1.15e-10 Coronary artery disease; CRC cis rs6951245 0.554 rs79367977 chr7:1152657 G/A cg26224354 chr7:1096374 C7orf50;GPR146 -0.57 -7.72 -0.39 1.38e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs10883723 0.810 rs13287 chr10:104240438 A/G cg04362960 chr10:104952993 NT5C2 -0.41 -5.63 -0.3 3.94e-8 Allergic disease (asthma, hay fever or eczema); CRC trans rs2507 0.817 rs16869 chr15:74322431 T/C cg01992487 chr16:84268524 KCNG4 0.39 5.98 0.31 5.84e-9 Coronary artery disease; CRC cis rs9287719 0.967 rs7566875 chr2:10754792 T/C cg00105475 chr2:10696890 NA 0.45 7.17 0.37 4.85e-12 Prostate cancer; CRC cis rs864537 0.646 rs2995091 chr1:167434277 T/C cg09179987 chr1:167433047 CD247 0.51 7.52 0.38 5.42e-13 Celiac disease or Rheumatoid arthritis;Celiac disease; CRC cis rs2070488 1.000 rs13058903 chr3:38513365 C/T cg01465620 chr3:38496096 LOC100128640;ACVR2B -0.89 -17.02 -0.68 4.91e-47 Electrocardiographic conduction measures; CRC cis rs7937682 0.632 rs12785809 chr11:111776055 T/A cg09085632 chr11:111637200 PPP2R1B 0.94 14.87 0.63 1.28e-38 Primary sclerosing cholangitis; CRC cis rs2408955 0.522 rs3997 chr12:48481587 T/C cg15465823 chr12:48382534 COL2A1 -0.38 -6.23 -0.32 1.44e-9 Glycated hemoglobin levels; CRC cis rs9549328 0.670 rs3011475 chr13:113616866 T/C cg24588162 chr13:113633484 MCF2L 0.36 6.47 0.34 3.52e-10 Systolic blood pressure; CRC cis rs62432291 0.681 rs2932988 chr6:159655402 A/G cg14500486 chr6:159655392 FNDC1 -0.76 -10.4 -0.5 4.17e-22 Joint mobility (Beighton score); CRC cis rs8078723 1.000 rs6503530 chr17:38161823 T/C cg17467752 chr17:38218738 THRA 0.74 12.03 0.55 7.35e-28 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); CRC cis rs116095464 0.558 rs28558836 chr5:285748 C/G cg22496380 chr5:211416 CCDC127 -0.84 -9.81 -0.48 4.26e-20 Breast cancer; CRC cis rs6908034 0.546 rs73376662 chr6:19806340 G/A cg02682789 chr6:19804855 NA 0.79 6.75 0.35 6.62e-11 Endometriosis;Deep ovarian and/or rectovaginal disease with dense adhesions; CRC cis rs7107174 1.000 rs7941617 chr11:78021146 C/T cg02023728 chr11:77925099 USP35 0.51 8.79 0.44 8.45e-17 Testicular germ cell tumor; CRC cis rs9733 0.519 rs7529194 chr1:150622620 A/T cg15448220 chr1:150897856 SETDB1 0.43 6.43 0.33 4.59e-10 Tonsillectomy; CRC cis rs58649573 0.530 rs2159792 chr9:126778821 A/G cg14112217 chr9:126806003 NA 0.41 5.87 0.31 1.07e-8 Post-traumatic stress disorder; CRC cis rs2050392 1.000 rs2250714 chr10:30697396 G/C cg18806716 chr10:30721971 MAP3K8 -0.47 -7.18 -0.37 4.58e-12 Inflammatory bowel disease; CRC trans rs35110281 0.774 rs2838321 chr21:44995488 A/T cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.42 6.62 0.34 1.44e-10 Mean corpuscular volume; CRC cis rs2404602 0.684 rs12437981 chr15:76842401 A/G cg03037974 chr15:76606532 NA -0.52 -7.91 -0.4 4.05e-14 Blood metabolite levels; CRC cis rs7666738 0.830 rs1813642 chr4:98852225 G/A cg17366294 chr4:99064904 C4orf37 0.41 6.83 0.35 4.19e-11 Colonoscopy-negative controls vs population controls; CRC cis rs5750830 0.649 rs7949 chr22:39827553 G/A cg24399712 chr22:39784796 NA -0.52 -10.78 -0.51 2.12e-23 Intelligence (multi-trait analysis); CRC cis rs62458065 0.640 rs4141788 chr7:32519264 T/C cg20159608 chr7:32802032 NA -0.59 -6.93 -0.36 2.19e-11 Metabolite levels (HVA/MHPG ratio); CRC cis rs12464483 0.591 rs72800120 chr2:30897122 G/A cg12454169 chr2:30669597 LCLAT1 0.65 7.53 0.38 4.98e-13 Pre-treatment pain in head and neck squamous cell carcinoma; CRC cis rs2836950 0.805 rs2836961 chr21:40627020 A/C cg06238570 chr21:40685208 BRWD1 -0.44 -5.63 -0.3 3.82e-8 Menarche (age at onset); CRC trans rs1728785 0.901 rs1645974 chr16:68564774 C/G cg04657470 chr2:198365150 HSPE1;HSPD1 0.57 6.78 0.35 5.72e-11 Ulcerative colitis; CRC cis rs11764590 0.585 rs11772463 chr7:2078132 A/C cg21155852 chr7:2048760 MAD1L1 -0.48 -6.33 -0.33 8.22e-10 Neuroticism; CRC cis rs3617 0.503 rs9866243 chr3:52915219 C/T cg18099408 chr3:52552593 STAB1 0.34 5.83 0.31 1.35e-8 Red blood cell count;Autism spectrum disorder or schizophrenia; CRC cis rs2786111 0.965 rs675699 chr1:197293606 G/A cg13682187 chr1:196946512 CFHR5 0.29 5.67 0.3 3.19e-8 Lupus nephritis in systemic lupus erythematosus; CRC cis rs2386661 0.637 rs7099771 chr10:5654742 A/G cg26603656 chr10:5671107 NA 0.4 7.21 0.37 3.86e-12 Breast cancer; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg21810621 chr11:1331345 LOC255512;TOLLIP 0.39 6.32 0.33 8.67e-10 Liver disease severity in Alagille syndrome; CRC cis rs7385804 0.761 rs504141 chr7:100309125 G/A cg20848291 chr7:100343083 ZAN 0.49 7.54 0.38 4.55e-13 Iron status biomarkers;Mean corpuscular hemoglobin;Hematocrit;Iron status biomarkers (transferrin saturation);Red blood cell count;Iron status biomarkers (iron levels);Mean corpuscular volume;Hematological parameters; CRC cis rs4731207 0.596 rs1481337 chr7:124667796 G/A cg23710748 chr7:124431027 NA -0.39 -6.19 -0.32 1.8e-9 Cutaneous malignant melanoma; CRC cis rs904251 0.523 rs2797796 chr6:37480886 T/C cg01843034 chr6:37503916 NA -0.44 -8.18 -0.41 6.11e-15 Cognitive performance; CRC cis rs933688 1.000 rs2367526 chr5:90740525 A/G cg02339078 chr5:90679543 LOC100129716;ARRDC3 0.88 13.58 0.6 1.14e-33 Smoking behavior; CRC cis rs2836974 0.863 rs6517519 chr21:40540245 A/G cg06238570 chr21:40685208 BRWD1 0.75 10.49 0.5 2.08e-22 Cognitive function; CRC cis rs7666738 0.830 rs880472 chr4:98922595 C/A cg17366294 chr4:99064904 C4orf37 0.43 7.32 0.37 1.95e-12 Colonoscopy-negative controls vs population controls; CRC cis rs2228479 0.850 rs11644213 chr16:89837367 C/T cg06656553 chr16:89960601 TCF25 0.71 6.09 0.32 3.22e-9 Skin colour saturation; CRC cis rs7666738 0.800 rs1559858 chr4:99024075 A/G cg17366294 chr4:99064904 C4orf37 0.43 7.16 0.37 5.15e-12 Colonoscopy-negative controls vs population controls; CRC cis rs7474896 0.526 rs1742235 chr10:38052256 T/C cg25427524 chr10:38739819 LOC399744 -0.64 -7.79 -0.39 9.06e-14 Obesity (extreme); CRC cis rs72717009 0.825 rs61802846 chr1:161473873 A/C cg23840854 chr1:161414152 NA -0.67 -7.98 -0.4 2.44e-14 Rheumatoid arthritis; CRC cis rs6691722 0.503 rs3765427 chr1:24705567 G/A cg18323236 chr1:24743029 NIPAL3 0.38 5.66 0.3 3.27e-8 Response to interferon beta in multiple sclerosis; CRC cis rs13118159 0.509 rs4974556 chr4:1358141 G/C cg16405210 chr4:1374714 KIAA1530 -0.92 -14.36 -0.62 1.23e-36 Longevity; CRC trans rs2797160 0.967 rs1739355 chr6:126018114 A/G cg05039488 chr6:79577232 IRAK1BP1 0.51 7.6 0.39 3.19e-13 Endometrial cancer; CRC cis rs1552244 0.882 rs3755783 chr3:10029289 A/G cg08888203 chr3:10149979 C3orf24 0.56 6.92 0.36 2.35e-11 Alzheimer's disease; CRC cis rs4363385 0.667 rs454245 chr1:153031979 A/C cg25856811 chr1:152973957 SPRR3 0.24 6.6 0.34 1.68e-10 Inflammatory skin disease; CRC cis rs2050392 0.517 rs589980 chr10:30756385 T/A cg18806716 chr10:30721971 MAP3K8 -0.58 -8.29 -0.42 2.92e-15 Inflammatory bowel disease; CRC cis rs9311474 0.607 rs28661185 chr3:52567188 G/T cg08222913 chr3:52553049 STAB1 -0.37 -7.03 -0.36 1.21e-11 Electroencephalogram traits; CRC cis rs3796619 1.000 rs4974638 chr4:1099201 G/A cg11579758 chr4:1086637 RNF212 0.41 6.57 0.34 1.96e-10 Recombination rate (males); CRC cis rs3806843 1.000 rs2098058 chr5:140157427 A/C cg16607685 chr5:140181889 PCDHA2;PCDHA1;PCDHA3 0.27 6.19 0.32 1.8e-9 Depressive symptoms (multi-trait analysis); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg01547494 chr13:110790937 NA 0.44 6.15 0.32 2.23e-9 Response to antipsychotic treatment; CRC cis rs904251 0.525 rs12200378 chr6:37425304 A/G cg01843034 chr6:37503916 NA -0.38 -6.77 -0.35 5.88e-11 Cognitive performance; CRC cis rs7769051 0.522 rs9493449 chr6:133126179 T/A cg22852734 chr6:133119734 C6orf192 1.12 8.39 0.42 1.43e-15 Type 2 diabetes nephropathy; CRC cis rs1030268 0.715 rs13235840 chr7:133505091 A/T cg10665199 chr7:133106180 EXOC4 0.55 6.09 0.32 3.09e-9 Intelligence (multi-trait analysis); CRC cis rs875971 0.862 rs4718330 chr7:65715243 G/A cg18876405 chr7:65276391 NA -0.51 -8.43 -0.42 1.12e-15 Aortic root size; CRC cis rs372883 0.901 rs733610 chr21:30656199 G/A cg24692254 chr21:30365293 RNF160 -0.39 -5.85 -0.31 1.17e-8 Pancreatic cancer; CRC cis rs55702914 0.712 rs12616329 chr2:198148629 T/C cg03934865 chr2:198174659 NA -0.36 -6.25 -0.33 1.27e-9 Major depression and alcohol dependence; CRC cis rs704795 0.836 rs1083865 chr2:27620827 A/G cg22903471 chr2:27725779 GCKR -0.38 -6.24 -0.33 1.37e-9 Menopause (age at onset); CRC cis rs12497850 0.931 rs7643368 chr3:48992855 T/G cg07636037 chr3:49044803 WDR6 1.03 18.7 0.72 1.12e-53 Parkinson's disease; CRC cis rs13191362 1.000 rs13214516 chr6:163121583 A/T cg14584255 chr6:163149320 PACRG;PARK2 0.45 6.43 0.33 4.58e-10 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs10540 1.000 rs61876336 chr11:489537 C/T cg03576123 chr11:487126 PTDSS2 -1.02 -10.25 -0.49 1.4e-21 Body mass index; CRC trans rs6952808 0.608 rs6461049 chr7:2017445 C/T cg04565464 chr8:145669602 NFKBIL2 -0.41 -6.24 -0.33 1.37e-9 Bipolar disorder and schizophrenia; CRC cis rs2290159 0.800 rs55762590 chr3:12689451 C/T cg23032965 chr3:12705835 RAF1 0.49 6.17 0.32 2.06e-9 Cholesterol, total; CRC cis rs4481887 0.927 rs4390209 chr1:248472613 A/T cg00666640 chr1:248458726 OR2T12 0.45 7.8 0.4 8.31e-14 Common traits (Other); CRC cis rs7633770 0.664 rs7373994 chr3:46701114 C/G cg11219411 chr3:46661640 NA -0.52 -7.82 -0.4 7.31e-14 Coronary artery disease; CRC cis rs2404602 0.692 rs1471780 chr15:77026526 T/C cg22467129 chr15:76604101 ETFA -0.41 -6.77 -0.35 5.95e-11 Blood metabolite levels; CRC cis rs2836974 0.666 rs35182074 chr21:40685284 A/C cg06238570 chr21:40685208 BRWD1 -0.87 -13.87 -0.61 9.35e-35 Cognitive function; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg10209635 chr21:37692467 MORC3 0.36 6.04 0.32 4.27e-9 Liver disease severity in Alagille syndrome; CRC trans rs2727020 0.521 rs11040377 chr11:49474346 T/C cg21153622 chr11:89784906 NA -0.44 -7.26 -0.37 2.74e-12 Coronary artery disease; CRC cis rs6502050 0.769 rs9904237 chr17:80119664 G/A cg22110888 chr17:80059540 CCDC57 0.4 6.38 0.33 5.96e-10 Life satisfaction; CRC cis rs7584330 0.518 rs74003104 chr2:238446823 C/T cg14458575 chr2:238380390 NA 0.7 8.62 0.43 2.8e-16 Prostate cancer; CRC cis rs67311347 1.000 rs9833430 chr3:40459043 C/T cg09455208 chr3:40491958 NA 0.47 9.25 0.45 2.94e-18 Renal cell carcinoma; CRC cis rs875971 0.862 rs13536 chr7:66019190 G/A cg12463550 chr7:65579703 CRCP -0.47 -6.45 -0.33 4.03e-10 Aortic root size; CRC cis rs78456975 0.527 rs7590742 chr2:1575049 A/T cg26248373 chr2:1572462 NA -0.83 -12.38 -0.56 3.62e-29 Placebo response in major depressive disorder (% change in symptom score); CRC cis rs7493 0.755 rs2375001 chr7:94964640 A/T cg21856205 chr7:94953877 PON1 -0.45 -5.91 -0.31 8.56e-9 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs6952808 0.609 rs4721190 chr7:1954732 A/G cg14004847 chr7:1930337 MAD1L1 0.47 6.86 0.35 3.42e-11 Bipolar disorder and schizophrenia; CRC cis rs9902453 0.619 rs2255489 chr17:28084974 A/G cg26525008 chr17:28256777 EFCAB5;SSH2 -0.59 -8.92 -0.44 3.21e-17 Coffee consumption (cups per day); CRC cis rs2635047 0.967 rs2668786 chr18:44708472 A/G cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.45 7.43 0.38 9.22e-13 Educational attainment; CRC cis rs916888 0.821 rs199509 chr17:44858728 G/A cg17911788 chr17:44343683 NA 0.56 6.86 0.35 3.4e-11 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs2832191 0.967 rs2832216 chr21:30521921 C/T cg24692254 chr21:30365293 RNF160 0.63 10.85 0.51 1.18e-23 Dental caries; CRC cis rs514406 0.505 rs440871 chr1:53173052 C/T cg24675658 chr1:53192096 ZYG11B -0.67 -10.36 -0.5 5.94e-22 Monocyte count; CRC cis rs4862750 0.957 rs4861733 chr4:187903933 C/T cg03452623 chr4:187889614 NA -0.95 -22.09 -0.77 6.03e-67 Lobe attachment (rater-scored or self-reported); CRC cis rs561341 0.883 rs2074102 chr17:30228884 G/A cg12193833 chr17:30244370 NA -0.68 -8.2 -0.41 5.56e-15 Hip circumference adjusted for BMI; CRC cis rs4319547 0.697 rs7974262 chr12:122896385 C/T cg05707623 chr12:122985044 ZCCHC8 0.78 9.76 0.47 6.3e-20 Body mass index; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg22443241 chr1:114447798 DCLRE1B;AP4B1 0.4 6.18 0.32 1.9e-9 Liver disease severity in Alagille syndrome; CRC cis rs9807841 0.592 rs10419865 chr19:10772685 C/G cg17710535 chr19:10819994 QTRT1 0.44 6.52 0.34 2.7e-10 Inflammatory skin disease; CRC cis rs6496667 0.865 rs7162697 chr15:90889337 A/C cg04176472 chr15:90893244 GABARAPL3 0.6 7.09 0.36 8.26e-12 Rheumatoid arthritis; CRC cis rs9296092 0.560 rs3846854 chr6:33528466 T/C cg13560919 chr6:33536144 NA -0.44 -6.28 -0.33 1.09e-9 Age at smoking initiation in chronic obstructive pulmonary disease; CRC cis rs4663866 0.901 rs71426513 chr2:239198147 G/A cg16914508 chr2:239161102 PER2 0.73 6.83 0.35 4.19e-11 Irritable bowel syndrome; CRC cis rs853679 0.517 rs67878650 chr6:28142587 G/C cg15786705 chr6:28176104 NA 0.78 9.7 0.47 1.01e-19 Depression; CRC cis rs2153535 0.541 rs6905934 chr6:8440043 C/A cg07606381 chr6:8435919 SLC35B3 0.68 10.86 0.51 1.08e-23 Motion sickness; CRC cis rs35995292 0.517 rs6948026 chr7:38920854 A/G cg19327137 chr7:38886074 VPS41 0.62 10.13 0.49 3.53e-21 Subjective well-being (multi-trait analysis); CRC cis rs9467603 0.592 rs1184498 chr6:25864882 G/C cg08501292 chr6:25962987 TRIM38 0.59 5.74 0.3 2.21e-8 Intelligence (multi-trait analysis); CRC trans rs1005277 0.579 rs2472175 chr10:38382901 T/G cg27523141 chr10:43048294 ZNF37B 0.5 7.23 0.37 3.41e-12 Extrinsic epigenetic age acceleration; CRC cis rs561341 0.941 rs550213 chr17:30317518 C/G cg00745463 chr17:30367425 LRRC37B -0.74 -8.94 -0.44 2.93e-17 Hip circumference adjusted for BMI; CRC trans rs1814175 0.645 rs4411280 chr11:49962750 A/G cg03929089 chr4:120376271 NA -0.91 -16.17 -0.67 1.06e-43 Height; CRC trans rs3780486 0.505 rs10758194 chr9:33157419 G/T cg04842962 chr6:43655489 MRPS18A 0.93 16.66 0.68 1.24e-45 IgG glycosylation; CRC cis rs7945718 0.870 rs3890065 chr11:12758767 C/G cg25843174 chr11:12811716 TEAD1 0.45 8.45 0.42 9.44e-16 Educational attainment (years of education); CRC cis rs7223966 1.000 rs8078462 chr17:61857937 T/G cg05941027 chr17:61774174 LIMD2 0.35 6.31 0.33 8.87e-10 Hip circumference adjusted for BMI;Body mass index; CRC cis rs2303759 0.666 rs66967196 chr19:49808894 G/A cg22133161 chr19:49891603 CCDC155 0.51 6.51 0.34 2.8e-10 Multiple sclerosis; CRC cis rs2404602 0.716 rs12592171 chr15:76755133 G/C cg23625390 chr15:77176239 SCAPER 0.5 7.38 0.38 1.29e-12 Blood metabolite levels; CRC cis rs4713118 0.738 rs200465 chr6:27757654 T/A cg06470822 chr6:28175283 NA 0.75 10.12 0.49 3.98e-21 Parkinson's disease; CRC trans rs7618501 0.902 rs7645061 chr3:49868842 C/T cg21665057 chr3:196295764 WDR53;FBXO45 0.86 15.99 0.66 5.77e-43 Intelligence (multi-trait analysis); CRC cis rs9549367 0.713 rs9549352 chr13:113833221 A/G cg00898013 chr13:113819073 PROZ -0.59 -8.21 -0.41 5.1e-15 Platelet distribution width; CRC trans rs8002861 0.840 rs1819596 chr13:44429554 A/G cg17145862 chr1:211918768 LPGAT1 0.71 14.01 0.61 2.65e-35 Leprosy; CRC cis rs4713118 0.869 rs9295742 chr6:27702832 G/A cg25164649 chr6:28176230 NA 0.58 8.19 0.41 5.97e-15 Parkinson's disease; CRC cis rs7493 1.000 rs3735586 chr7:95035582 A/T cg19678392 chr7:94953810 PON1 -0.56 -7.18 -0.37 4.53e-12 Yu-Zhi constitution type in type 2 diabetes; CRC trans rs877282 1.000 rs11253366 chr10:773386 C/T cg22713356 chr15:30763199 NA 1.13 14.67 0.63 8.07e-38 Uric acid levels; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg20376421 chr12:56546193 MYL6B 0.42 6.73 0.35 7.45e-11 Liver disease severity in Alagille syndrome; CRC cis rs10504229 0.636 rs117439064 chr8:58055279 A/G cg21724239 chr8:58056113 NA 0.72 8.73 0.43 1.31e-16 Developmental language disorder (linguistic errors); CRC cis rs7224685 1.000 rs7224685 chr17:4014384 G/T cg05562828 chr17:3906858 NA 0.45 6.95 0.36 1.96e-11 Type 2 diabetes; CRC cis rs9733 0.596 rs12063547 chr1:150674053 G/T cg17724175 chr1:150552817 MCL1 -0.57 -9.08 -0.45 9.92e-18 Tonsillectomy; CRC cis rs2070488 0.775 rs13072731 chr3:38533335 A/C cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.82 14.2 0.62 4.86e-36 Electrocardiographic conduction measures; CRC cis rs59104589 0.617 rs73002170 chr2:242325980 G/A cg19488206 chr2:242435732 STK25 0.47 6.69 0.35 9.9e-11 Fibrinogen levels; CRC cis rs72634258 0.945 rs12745223 chr1:8094978 C/T cg26816564 chr1:7831052 VAMP3 0.56 6.03 0.32 4.29e-9 Inflammatory bowel disease; CRC cis rs3736485 0.966 rs2414109 chr15:51901015 C/G cg08986416 chr15:51914746 DMXL2 -0.46 -6.69 -0.35 9.6e-11 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs595982 0.527 rs55706579 chr19:49382969 G/A cg21252483 chr19:49399788 TULP2 -0.42 -6.47 -0.34 3.47e-10 Red cell distribution width; CRC cis rs57221529 0.766 rs12522303 chr5:555564 A/C cg16447950 chr5:562315 NA -0.84 -11.5 -0.54 6.14e-26 Lung disease severity in cystic fibrosis; CRC cis rs11764590 0.715 rs11766468 chr7:2082604 G/A cg24505167 chr7:1915268 MAD1L1 -0.43 -5.92 -0.31 8.13e-9 Neuroticism; CRC cis rs7917772 0.503 rs11191342 chr10:104344450 G/A cg11453585 chr10:104263688 ACTR1A;SUFU 0.88 16.12 0.66 1.64e-43 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC cis rs736408 0.716 rs2239549 chr3:52823126 C/T cg15147215 chr3:52552868 STAB1 -0.54 -8.28 -0.42 3.14e-15 Bipolar disorder; CRC cis rs1552244 1.000 rs6764168 chr3:10123805 A/G cg02579736 chr3:10068473 FANCD2;CIDECP 1.02 13.64 0.6 6.69e-34 Alzheimer's disease; CRC cis rs11212617 0.967 rs227040 chr11:108223391 T/C cg14761454 chr11:108092087 ATM;NPAT 0.43 6.54 0.34 2.3e-10 Response to metformin in type 2 diabetes (glycemic); CRC cis rs57590327 0.503 rs9866374 chr3:81615311 T/C cg07356753 chr3:81810745 GBE1 -0.52 -6.86 -0.35 3.51e-11 Extraversion; CRC cis rs832540 0.618 rs2548663 chr5:56172778 G/A cg12311346 chr5:56204834 C5orf35 -0.53 -7.67 -0.39 1.98e-13 Coronary artery disease; CRC cis rs17401966 1.000 rs2229687 chr1:10473196 C/T cg19773385 chr1:10388646 KIF1B -0.67 -10.51 -0.5 1.84e-22 Hepatocellular carcinoma; CRC cis rs1538970 0.739 rs4660863 chr1:45955868 T/C cg05343316 chr1:45956843 TESK2 0.75 9.79 0.48 4.94e-20 Platelet count; CRC cis rs7615952 0.599 rs2333408 chr3:125732098 G/A cg02807482 chr3:125708958 NA -0.41 -5.68 -0.3 2.9e-8 Blood pressure (smoking interaction); CRC trans rs7395662 0.963 rs11499897 chr11:48717866 G/A cg21153622 chr11:89784906 NA 0.46 7.41 0.38 1.05e-12 HDL cholesterol; CRC cis rs3106136 0.967 rs8026 chr4:95212185 A/G cg11021082 chr4:95130006 SMARCAD1 -0.46 -7.09 -0.36 8.28e-12 Capecitabine sensitivity; CRC cis rs9902453 0.904 rs12939344 chr17:28328819 C/G cg26525008 chr17:28256777 EFCAB5;SSH2 -0.72 -12.21 -0.56 1.53e-28 Coffee consumption (cups per day); CRC cis rs17345786 0.906 rs12638137 chr3:101150964 C/T cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.6 6.87 0.35 3.15e-11 Colonoscopy-negative controls vs population controls; CRC trans rs4130344 0.901 rs12506223 chr4:159685197 C/T cg01113538 chr6:53658866 LRRC1 0.41 5.98 0.31 5.79e-9 Intelligence (multi-trait analysis); CRC cis rs2204008 0.599 rs2320526 chr12:38220405 T/A cg13010199 chr12:38710504 ALG10B 0.44 5.84 0.31 1.28e-8 Bladder cancer; CRC cis rs7615952 0.576 rs66671308 chr3:125793526 T/G cg02772935 chr3:125709198 NA -0.49 -5.8 -0.3 1.57e-8 Blood pressure (smoking interaction); CRC cis rs9322193 0.847 rs12210605 chr6:150138403 A/G cg05861140 chr6:150128134 PCMT1 -0.4 -6.05 -0.32 4.01e-9 Lung cancer; CRC cis rs9649465 1.000 rs2052128 chr7:123380405 T/A cg03229431 chr7:123269106 ASB15 -0.36 -5.67 -0.3 3.21e-8 Migraine; CRC cis rs10484885 0.824 rs72919981 chr6:90528977 T/C cg13799429 chr6:90582589 CASP8AP2 -0.72 -7.76 -0.39 1.12e-13 QRS interval (sulfonylurea treatment interaction); CRC cis rs4711350 1.000 rs943472 chr6:33738442 T/C cg07979401 chr6:33739406 LEMD2 -0.48 -5.92 -0.31 7.98e-9 Schizophrenia; CRC cis rs6496044 0.568 rs12898783 chr15:86066100 G/C cg17133734 chr15:86042851 AKAP13 0.4 6.51 0.34 2.8e-10 Interstitial lung disease; CRC cis rs7666738 0.830 rs11725652 chr4:98878362 G/A cg17366294 chr4:99064904 C4orf37 0.41 6.74 0.35 7.11e-11 Colonoscopy-negative controls vs population controls; CRC cis rs752010 0.806 rs10890148 chr1:42091517 T/C cg06885757 chr1:42089581 HIVEP3 0.46 8.25 0.41 3.83e-15 Lupus nephritis in systemic lupus erythematosus; CRC cis rs736408 0.545 rs6445529 chr3:52662722 T/A cg10802521 chr3:52805072 NEK4 -0.56 -8.85 -0.44 5.49e-17 Bipolar disorder; CRC cis rs2836950 0.520 rs2836966 chr21:40637521 A/G cg11644478 chr21:40555479 PSMG1 -0.46 -6.81 -0.35 4.76e-11 Menarche (age at onset); CRC cis rs11229555 0.645 rs11229457 chr11:58207203 C/T cg15696309 chr11:58395628 NA -0.82 -10.31 -0.49 8.59e-22 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; CRC cis rs7909074 0.831 rs7903412 chr10:45382361 C/T cg04218760 chr10:45406644 TMEM72 -0.34 -9.69 -0.47 1.04e-19 Mean corpuscular volume; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg12302830 chr20:33297742 TP53INP2 0.43 6.36 0.33 6.77e-10 Intelligence (multi-trait analysis); CRC trans rs9388451 0.868 rs10457467 chr6:126045148 T/A cg05039488 chr6:79577232 IRAK1BP1 -0.56 -8.6 -0.43 3.21e-16 Brugada syndrome; CRC cis rs12594515 0.506 rs74199860 chr15:45989190 C/T cg19682013 chr15:45996608 NA 0.32 6.67 0.35 1.06e-10 Waist circumference;Weight; CRC cis rs2411233 1.000 rs12910064 chr15:39283736 T/A cg23129342 chr15:39283510 NA 0.3 5.68 0.3 2.92e-8 Platelet count; CRC cis rs3812762 0.833 rs10500707 chr11:8817580 C/T cg21881798 chr11:8931708 C11orf17;ST5 0.42 6.33 0.33 8.2e-10 Hypospadias; CRC cis rs651907 0.514 rs55654108 chr3:101425703 A/G cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.6 8.15 0.41 7.73e-15 Colorectal cancer; CRC cis rs2243480 1.000 rs160646 chr7:65556280 C/T cg18252515 chr7:66147081 NA -1.14 -13.79 -0.61 1.82e-34 Diabetic kidney disease; CRC cis rs752010 0.530 rs10789401 chr1:42081111 A/G cg06885757 chr1:42089581 HIVEP3 0.67 11.66 0.54 1.62e-26 Lupus nephritis in systemic lupus erythematosus; CRC cis rs7827545 1.000 rs7008158 chr8:135565982 T/C cg13086574 chr8:135490821 ZFAT -0.36 -6.08 -0.32 3.34e-9 Hypertension (SNP x SNP interaction); CRC cis rs2180341 0.618 rs6683 chr6:127610021 G/A cg27446573 chr6:127587934 RNF146 0.63 9.39 0.46 1.01e-18 Breast cancer; CRC cis rs62244186 0.715 rs10212378 chr3:44667286 C/G cg11003573 chr3:44754125 ZNF502 -0.36 -6.33 -0.33 7.96e-10 Depressive symptoms; CRC cis rs6570726 0.935 rs390252 chr6:145856896 A/G cg05347473 chr6:146136440 FBXO30 0.38 6.1 0.32 2.92e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs4713118 0.955 rs9468201 chr6:27687035 C/T cg12172441 chr6:28176163 NA 0.47 6.17 0.32 2.06e-9 Parkinson's disease; CRC trans rs2242420 0.920 rs853480 chr1:21949537 A/G cg16903735 chr11:1903176 LSP1 0.41 6.11 0.32 2.76e-9 Hematological and biochemical traits; CRC cis rs4919694 0.611 rs75182663 chr10:105058104 A/G cg04362960 chr10:104952993 NT5C2 0.8 7.65 0.39 2.29e-13 Arsenic metabolism; CRC cis rs6570726 0.791 rs440477 chr6:145854188 C/T cg05347473 chr6:146136440 FBXO30 0.39 5.92 0.31 8.19e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs7781557 1.000 rs17135875 chr7:102519031 T/C cg18108683 chr7:102477205 FBXL13 -0.49 -6.37 -0.33 6.38e-10 Colorectal adenoma (advanced); CRC cis rs6545883 0.868 rs2518933 chr2:61797030 C/A cg15711740 chr2:61764176 XPO1 -0.52 -7.08 -0.36 8.63e-12 Tuberculosis; CRC cis rs3750082 0.785 rs4720085 chr7:32968136 C/T cg05721444 chr7:32995514 FKBP9 -0.5 -7.81 -0.4 7.66e-14 Glomerular filtration rate (creatinine); CRC cis rs28386778 0.897 rs2597634 chr17:61878144 G/A cg25654072 chr17:61904446 PSMC5;FTSJ3 0.74 11.5 0.54 6.02e-26 Prudent dietary pattern; CRC trans rs1728785 0.892 rs1170427 chr16:68603852 G/T cg04657470 chr2:198365150 HSPE1;HSPD1 0.59 7.14 0.37 6.11e-12 Ulcerative colitis; CRC cis rs9322193 0.962 rs2342861 chr6:150098697 C/T cg00933542 chr6:150070202 PCMT1 0.28 5.63 0.3 3.86e-8 Lung cancer; CRC cis rs780096 0.506 rs2950834 chr2:27627366 G/A cg17158414 chr2:27665306 KRTCAP3 -0.28 -6.14 -0.32 2.37e-9 Total body bone mineral density; CRC cis rs4713118 0.738 rs200465 chr6:27757654 T/A cg12273811 chr6:28175739 NA 0.5 6.69 0.35 9.68e-11 Parkinson's disease; CRC cis rs875971 0.928 rs2036263 chr7:65800197 C/T cg12463550 chr7:65579703 CRCP -0.53 -7.51 -0.38 5.45e-13 Aortic root size; CRC cis rs7647973 0.516 rs4955419 chr3:49200692 T/A cg07690219 chr3:49449608 TCTA;RHOA -0.44 -5.76 -0.3 1.91e-8 Menarche (age at onset); CRC cis rs3087591 0.919 rs2012581 chr17:29560800 A/G cg24425628 chr17:29625626 OMG;NF1 -0.82 -15.62 -0.65 1.53e-41 Hip circumference; CRC cis rs9303401 0.614 rs2240719 chr17:56582477 G/C cg02118635 chr17:56770003 RAD51C;TEX14 0.78 9.7 0.47 1.02e-19 Cognitive test performance; CRC cis rs7224737 1.000 rs9889618 chr17:40293467 C/T cg00647820 chr17:40259828 DHX58 -0.46 -6.5 -0.34 3.04e-10 Fibrinogen levels; CRC cis rs782590 0.537 rs12619903 chr2:55884106 T/A cg18811423 chr2:55921094 PNPT1 -0.68 -9.31 -0.46 1.8e-18 Metabolic syndrome; CRC cis rs7811142 1.000 rs7803454 chr7:99991548 C/T cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.13 14.91 0.64 8.81e-39 Platelet count; CRC cis rs1580019 0.922 rs1466147 chr7:32486262 C/T cg06627557 chr7:32535165 LSM5;AVL9 0.82 12.48 0.57 1.58e-29 Cognitive ability; CRC cis rs9291683 0.507 rs6827754 chr4:10018153 A/C cg11266682 chr4:10021025 SLC2A9 -0.52 -10.59 -0.5 9.79e-23 Bone mineral density; CRC trans rs4650994 0.524 rs2209170 chr1:178607388 C/A cg05059571 chr16:84539110 KIAA1609 0.58 7.88 0.4 4.86e-14 HDL cholesterol levels;HDL cholesterol; CRC cis rs597539 0.615 rs583182 chr11:68678634 C/T cg04772025 chr11:68637568 NA 0.47 7.51 0.38 5.76e-13 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs2243480 1.000 rs4718309 chr7:65627764 G/C cg25985355 chr7:65971099 NA 0.53 6.05 0.32 3.9e-9 Diabetic kidney disease; CRC cis rs1005277 0.579 rs2103938 chr10:38493998 T/G cg17219203 chr10:38645113 HSD17B7P2 -0.41 -5.92 -0.31 8.29e-9 Extrinsic epigenetic age acceleration; CRC cis rs798554 0.610 rs2527696 chr7:2858315 T/C cg17321639 chr7:2759063 NA -0.37 -5.71 -0.3 2.58e-8 Height; CRC trans rs4576506 0.536 rs35257125 chr9:31500452 C/T cg26940518 chr16:1593766 IFT140;TMEM204 -0.66 -6.02 -0.31 4.6e-9 Psychosis and Alzheimer's disease; CRC cis rs7249142 0.549 rs741706 chr19:19281672 C/T cg12558012 chr19:19281197 LOC729991-MEF2B;MEF2B 0.59 9.29 0.46 2.22e-18 IgG glycosylation; CRC cis rs4713118 0.869 rs2056925 chr6:27690905 A/G cg26587870 chr6:27730563 NA -0.45 -7.0 -0.36 1.46e-11 Parkinson's disease; CRC cis rs9611565 0.559 rs739136 chr22:42100275 C/T cg03806693 chr22:41940476 POLR3H -1.07 -13.6 -0.6 1.02e-33 Vitiligo; CRC cis rs9372498 0.505 rs62424173 chr6:118780507 C/G cg10217327 chr6:118973057 C6orf204 0.51 5.76 0.3 1.93e-8 Diastolic blood pressure; CRC cis rs10751667 0.621 rs7394862 chr11:927500 T/C ch.11.42038R chr11:967971 AP2A2 0.6 10.22 0.49 1.72e-21 Alzheimer's disease (late onset); CRC cis rs3091242 0.867 rs602052 chr1:25722206 T/C cg23205692 chr1:25664452 TMEM50A 0.42 6.07 0.32 3.55e-9 Erythrocyte sedimentation rate; CRC cis rs4149423 1.000 rs4149420 chr2:108913090 G/T cg06795125 chr2:108905320 SULT1C2 -0.4 -6.48 -0.34 3.36e-10 Lobe size; CRC cis rs17767392 0.881 rs61991199 chr14:71762542 C/T cg13720639 chr14:72061746 SIPA1L1 -0.53 -6.86 -0.35 3.45e-11 Mitral valve prolapse; CRC cis rs1153858 1.000 rs12594857 chr15:45667178 A/G cg10760299 chr15:45669010 GATM 0.5 7.9 0.4 4.16e-14 Homoarginine levels; CRC cis rs8067545 0.586 rs2703819 chr17:20121401 A/G cg13482628 chr17:19912719 NA -0.47 -7.35 -0.38 1.55e-12 Schizophrenia; CRC cis rs12893668 0.572 rs4900590 chr14:104146421 C/T cg08213375 chr14:104286397 PPP1R13B 0.44 6.9 0.36 2.71e-11 Reticulocyte count; CRC cis rs1712517 1.000 rs3123794 chr10:105033742 A/G cg05636881 chr10:105038444 INA 0.47 8.33 0.42 2.18e-15 Migraine; CRC cis rs780096 0.546 rs2293571 chr2:27729480 C/T cg27432699 chr2:27873401 GPN1 -0.61 -9.78 -0.47 5.29e-20 Total body bone mineral density; CRC cis rs13108904 0.967 rs11247987 chr4:1294532 G/A cg00684032 chr4:1343700 KIAA1530 0.47 6.79 0.35 5.23e-11 Obesity-related traits; CRC cis rs2708977 1.000 rs10184209 chr2:97337491 G/T cg01950434 chr2:97203154 ARID5A 0.47 6.91 0.36 2.51e-11 Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes; CRC cis rs6570726 0.755 rs2092296 chr6:145893684 A/C cg13319975 chr6:146136371 FBXO30 -0.42 -6.22 -0.32 1.53e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs4819052 1.000 rs28628220 chr21:46663741 G/C cg02159808 chr21:46707872 POFUT2;LOC642852 0.63 7.74 0.39 1.2e-13 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs9323205 0.861 rs56137183 chr14:51693463 C/A cg23942311 chr14:51606299 NA -0.5 -6.03 -0.32 4.29e-9 Cancer; CRC cis rs4713118 0.662 rs9468271 chr6:28024570 A/G cg21251018 chr6:28226885 NKAPL 0.46 6.42 0.33 4.71e-10 Parkinson's disease; CRC cis rs9381040 0.610 rs742495 chr6:41018233 A/G cg03644281 chr6:41068752 NFYA;LOC221442 -0.45 -6.42 -0.33 4.71e-10 Alzheimer's disease (late onset); CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg01904774 chr5:159546218 PWWP2A 0.45 6.19 0.32 1.77e-9 Anxiety disorder; CRC cis rs875971 0.756 rs2901210 chr7:66017505 G/A cg18252515 chr7:66147081 NA 0.42 6.1 0.32 2.9e-9 Aortic root size; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg14766148 chr2:128786246 SAP130 0.47 6.42 0.33 4.83e-10 Thyroid stimulating hormone; CRC cis rs1218582 0.772 rs877343 chr1:154910012 A/G cg09359103 chr1:154839909 KCNN3 -0.7 -12.18 -0.56 1.93e-28 Prostate cancer; CRC cis rs7945718 0.621 rs10831890 chr11:12671211 A/G cg25843174 chr11:12811716 TEAD1 0.39 6.99 0.36 1.55e-11 Educational attainment (years of education); CRC cis rs67311347 0.577 rs2887951 chr3:40282104 C/G cg09455208 chr3:40491958 NA 0.34 6.87 0.35 3.29e-11 Renal cell carcinoma; CRC cis rs1865760 1.000 rs7770139 chr6:25925823 A/G cg16482183 chr6:26056742 HIST1H1C 0.54 7.7 0.39 1.61e-13 Height; CRC cis rs9287719 0.649 rs2160258 chr2:10717221 T/A cg00105475 chr2:10696890 NA 0.45 7.08 0.36 8.74e-12 Prostate cancer; CRC trans rs7613875 0.580 rs11709503 chr3:49991167 G/T cg21659725 chr3:3221576 CRBN 0.44 6.42 0.33 4.86e-10 Body mass index; CRC cis rs6089584 0.854 rs8117075 chr20:60613766 T/C cg12751644 chr20:60527061 NA -0.38 -5.95 -0.31 6.72e-9 Body mass index; CRC cis rs2976388 0.578 rs13263987 chr8:143827387 A/C cg10596483 chr8:143751796 JRK -0.48 -6.6 -0.34 1.69e-10 Urinary tract infection frequency; CRC cis rs400736 0.602 rs6694154 chr1:8163520 G/A cg25007680 chr1:8021821 PARK7 -0.49 -6.68 -0.35 1.01e-10 Response to antidepressants and depression; CRC cis rs5753618 0.561 rs2073857 chr22:31658281 A/G cg07713946 chr22:31675144 LIMK2 -0.4 -5.75 -0.3 2e-8 Colorectal cancer; CRC cis rs9462027 0.628 rs2764197 chr6:34705055 T/C cg07306190 chr6:34760872 UHRF1BP1 -0.34 -6.07 -0.32 3.49e-9 Systemic lupus erythematosus; CRC cis rs7223966 1.000 rs9899491 chr17:61934384 G/C cg23090583 chr17:61904693 PSMC5;FTSJ3 0.57 7.11 0.36 7.27e-12 Hip circumference adjusted for BMI;Body mass index; CRC cis rs2204008 0.702 rs8175764 chr12:38363690 T/C cg26384229 chr12:38710491 ALG10B 0.69 9.8 0.48 4.77e-20 Bladder cancer; CRC cis rs6952808 0.689 rs2008263 chr7:2048335 A/G cg04267008 chr7:1944627 MAD1L1 -0.71 -10.31 -0.49 8.47e-22 Bipolar disorder and schizophrenia; CRC cis rs727505 1.000 rs720613 chr7:124452670 C/T cg23710748 chr7:124431027 NA -0.68 -12.04 -0.55 6.68e-28 Lewy body disease; CRC cis rs6840360 1.000 rs3792691 chr4:152635803 C/T cg09659197 chr4:152720779 NA -0.53 -11.86 -0.55 2.88e-27 Intelligence (multi-trait analysis); CRC trans rs1455244 0.700 rs7229302 chr18:11508904 G/T cg24711626 chr18:29522957 KIAA1012 0.37 6.04 0.32 4.28e-9 Schizophrenia; CRC cis rs11148252 0.564 rs2296350 chr13:52710044 T/C cg12458913 chr13:53173898 NA 0.43 6.37 0.33 6.51e-10 Lewy body disease; CRC cis rs7613875 0.620 rs7624030 chr3:50071279 A/C cg05623727 chr3:50126028 RBM5 -0.59 -10.19 -0.49 2.27e-21 Body mass index; CRC cis rs4750440 0.733 rs2446585 chr10:14028086 C/T cg04819048 chr10:14014548 FRMD4A 0.35 5.7 0.3 2.66e-8 Adiponectin levels; CRC cis rs2294693 0.945 rs932399 chr6:41011266 C/T cg14769373 chr6:40998127 UNC5CL -0.51 -6.62 -0.34 1.49e-10 Gastric cancer;Non-cardia gastric cancer; CRC trans rs7615952 0.546 rs112919177 chr3:125346070 G/A cg02560186 chr11:3602584 NA -0.56 -6.98 -0.36 1.63e-11 Blood pressure (smoking interaction); CRC cis rs6540559 0.932 rs764093 chr1:209983331 A/G cg23283495 chr1:209979779 IRF6 0.43 6.94 0.36 2.04e-11 Cleft lip with or without cleft palate; CRC cis rs7208859 0.623 rs57486336 chr17:29085731 G/T cg01831904 chr17:28903510 LRRC37B2 -0.63 -6.45 -0.33 4.07e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs611744 0.647 rs1379336 chr8:109276606 G/T cg18478394 chr8:109455254 TTC35 0.38 5.81 0.3 1.49e-8 Dupuytren's disease; CRC cis rs6952808 0.692 rs11765549 chr7:2027311 G/T cg04267008 chr7:1944627 MAD1L1 -0.8 -11.39 -0.53 1.47e-25 Bipolar disorder and schizophrenia; CRC cis rs2073300 0.609 rs1076776 chr20:23427399 C/T cg12062639 chr20:23401060 NAPB -0.86 -8.17 -0.41 6.75e-15 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs11229555 0.598 rs7930623 chr11:58197641 A/G cg15696309 chr11:58395628 NA -0.82 -10.31 -0.49 8.59e-22 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; CRC cis rs11650494 0.831 rs7216993 chr17:47454263 A/G cg08112188 chr17:47440006 ZNF652 0.93 9.68 0.47 1.18e-19 Prostate cancer; CRC cis rs6540559 1.000 rs2073485 chr1:209962794 G/A cg21951975 chr1:209979733 IRF6 0.48 6.9 0.36 2.76e-11 Cleft lip with or without cleft palate; CRC cis rs7208859 0.623 rs9891166 chr17:29111902 G/A cg01831904 chr17:28903510 LRRC37B2 -0.63 -6.45 -0.33 4.07e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs6582630 0.502 rs10880092 chr12:38262965 A/T cg13010199 chr12:38710504 ALG10B 0.45 5.75 0.3 2.07e-8 Drug-induced liver injury (flucloxacillin); CRC cis rs4731207 0.596 rs6971413 chr7:124592668 C/A cg23710748 chr7:124431027 NA -0.38 -6.08 -0.32 3.35e-9 Cutaneous malignant melanoma; CRC cis rs1832871 0.672 rs56326208 chr6:158762944 C/T cg07165851 chr6:158734300 TULP4 0.62 7.89 0.4 4.38e-14 Height; CRC cis rs11098499 0.645 rs78422072 chr4:120281042 C/T cg24375607 chr4:120327624 NA 0.47 7.15 0.37 5.66e-12 Corneal astigmatism; CRC cis rs6461049 0.646 rs3778970 chr7:2143208 C/A cg04267008 chr7:1944627 MAD1L1 -0.67 -9.27 -0.46 2.44e-18 Schizophrenia; CRC cis rs7568458 0.783 rs2166529 chr2:85742175 A/C cg02493740 chr2:85810744 VAMP5 0.36 5.78 0.3 1.77e-8 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); CRC cis rs13108904 0.967 rs11727167 chr4:1285521 A/G cg00684032 chr4:1343700 KIAA1530 0.47 6.82 0.35 4.46e-11 Obesity-related traits; CRC cis rs1143633 0.530 rs4538207 chr2:113701863 G/T cg06156847 chr2:113672199 IL1F7 -0.45 -6.78 -0.35 5.59e-11 Allergic disease (asthma, hay fever or eczema); CRC cis rs7209700 0.547 rs10514919 chr17:45342129 G/T cg17185639 chr17:45330862 ITGB3 0.37 5.74 0.3 2.12e-8 IgG glycosylation; CRC cis rs1862618 0.853 rs33326 chr5:56142601 G/A cg03609598 chr5:56110824 MAP3K1 -0.82 -9.92 -0.48 1.82e-20 Initial pursuit acceleration; CRC cis rs449789 0.857 rs2501175 chr6:159714412 C/T cg14500486 chr6:159655392 FNDC1 -0.48 -7.29 -0.37 2.38e-12 Pulse pressure; CRC cis rs2204008 0.597 rs4002591 chr12:38133841 A/G cg26384229 chr12:38710491 ALG10B 0.68 9.11 0.45 7.97e-18 Bladder cancer; CRC cis rs4665809 0.590 rs11552518 chr2:26455127 G/A cg22920501 chr2:26401640 FAM59B 0.85 12.21 0.56 1.54e-28 Gut microbiome composition (summer); CRC cis rs1670533 0.746 rs688008 chr4:1082829 T/C cg27284194 chr4:1044797 NA 0.49 6.24 0.33 1.37e-9 Recombination rate (females); CRC cis rs7107174 1.000 rs2510037 chr11:77966099 A/G cg02023728 chr11:77925099 USP35 0.52 8.95 0.44 2.62e-17 Testicular germ cell tumor; CRC cis rs11098499 0.863 rs7664986 chr4:120429952 A/C cg09307838 chr4:120376055 NA 0.68 10.32 0.49 8.02e-22 Corneal astigmatism; CRC cis rs11958404 0.932 rs72816571 chr5:157429759 C/T cg05962755 chr5:157440814 NA 1.01 12.88 0.58 5.12e-31 IgG glycosylation; CRC cis rs55665837 1.000 rs11023214 chr11:14436259 G/C cg19336497 chr11:14380999 RRAS2 -0.39 -6.68 -0.35 1.02e-10 Vitamin D levels; CRC cis rs10486722 0.606 rs6976125 chr7:41803706 T/A cg22138096 chr7:41772439 LOC285954 0.62 7.46 0.38 7.59e-13 Pit-and-Fissure caries; CRC cis rs2739330 0.734 rs2000467 chr22:24241533 C/T cg11060661 chr22:24314208 DDT;DDTL -0.47 -7.71 -0.39 1.51e-13 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs1552244 0.744 rs6763366 chr3:10033544 T/C cg08888203 chr3:10149979 C3orf24 0.62 8.3 0.42 2.65e-15 Alzheimer's disease; CRC cis rs11190604 1.000 rs2495760 chr10:102318771 T/C cg16342193 chr10:102329863 NA -0.4 -6.39 -0.33 5.63e-10 Palmitoleic acid (16:1n-7) levels; CRC cis rs1506636 1.000 rs2402671 chr7:123355483 T/C cg03229431 chr7:123269106 ASB15 -0.74 -11.96 -0.55 1.28e-27 Plateletcrit;Platelet count; CRC trans rs1005277 0.505 rs7099777 chr10:38183569 A/C cg23533926 chr12:111358616 MYL2 0.45 6.6 0.34 1.69e-10 Extrinsic epigenetic age acceleration; CRC cis rs9341808 0.718 rs4437429 chr6:80828592 A/G cg08355045 chr6:80787529 NA 0.43 6.89 0.36 2.84e-11 Sitting height ratio; CRC trans rs61931739 0.500 rs10772160 chr12:34456848 G/A cg13010199 chr12:38710504 ALG10B 0.46 6.5 0.34 3.07e-10 Morning vs. evening chronotype; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg01106354 chr16:68278916 PLA2G15 0.41 6.32 0.33 8.48e-10 Intelligence (multi-trait analysis); CRC trans rs10983614 1.000 rs7867776 chr9:120072627 A/G cg08942682 chr3:197409980 KIAA0226 0.45 6.12 0.32 2.7e-9 Survival in pancreatic cancer; CRC cis rs6662572 1.000 rs3014232 chr1:46131873 T/C cg08644498 chr1:46502608 NA 0.45 6.79 0.35 5.14e-11 Blood protein levels; CRC cis rs2290159 0.800 rs57884385 chr3:12673551 G/C cg23032965 chr3:12705835 RAF1 0.5 6.38 0.33 5.92e-10 Cholesterol, total; CRC cis rs9916302 0.904 rs7503069 chr17:37697128 C/G cg15445000 chr17:37608096 MED1 0.43 9.43 0.46 7.8e-19 Glomerular filtration rate (creatinine); CRC cis rs11785400 1.000 rs4297023 chr8:143733307 C/A cg10596483 chr8:143751796 JRK 0.49 7.0 0.36 1.46e-11 Schizophrenia; CRC cis rs4713675 0.584 rs7739505 chr6:33670370 G/A cg14003231 chr6:33640908 ITPR3 0.49 7.99 0.4 2.34e-14 Plateletcrit; CRC cis rs10788264 0.504 rs7898942 chr10:124024608 G/T cg05683857 chr10:124030795 BTBD16 -0.31 -5.72 -0.3 2.37e-8 Total body bone mineral density; CRC cis rs78456975 1.000 rs72776252 chr2:1525599 G/A cg26248373 chr2:1572462 NA -0.63 -6.54 -0.34 2.3e-10 Placebo response in major depressive disorder (% change in symptom score); CRC cis rs12681287 0.640 rs12541793 chr8:87462558 G/A cg27223183 chr8:87520930 FAM82B -0.52 -7.44 -0.38 8.7e-13 Caudate activity during reward; CRC cis rs2842992 0.672 rs4708845 chr6:160219601 T/G cg16489826 chr6:160211363 TCP1;MRPL18 0.5 6.19 0.32 1.79e-9 Age-related macular degeneration (geographic atrophy); CRC cis rs2737618 0.680 rs2737686 chr1:200094347 C/T cg21825944 chr1:200113062 NR5A2 -0.51 -7.07 -0.36 9.11e-12 Uric acid levels; CRC cis rs853679 0.517 rs4713145 chr6:28106827 T/C cg23161317 chr6:28129485 ZNF389 0.53 6.54 0.34 2.37e-10 Depression; CRC cis rs847577 0.630 rs6967926 chr7:97715088 C/T cg00277769 chr7:97922759 BAIAP2L1 -0.39 -6.6 -0.34 1.7e-10 Breast cancer; CRC cis rs853679 0.517 rs3757185 chr6:28107776 T/A cg06470822 chr6:28175283 NA 1.0 13.33 0.59 1.06e-32 Depression; CRC cis rs67478160 0.643 rs7156697 chr14:104211136 G/A cg01849466 chr14:104193079 ZFYVE21 -0.48 -8.4 -0.42 1.32e-15 Schizophrenia; CRC cis rs1395 1.000 rs6717980 chr2:27452784 T/C cg23587288 chr2:27483067 SLC30A3 -0.32 -5.67 -0.3 3.09e-8 Blood metabolite levels; CRC trans rs7647973 0.626 rs1463728 chr3:49647404 T/A cg21659725 chr3:3221576 CRBN -0.66 -7.18 -0.37 4.68e-12 Menarche (age at onset); CRC cis rs4925386 0.840 rs6143034 chr20:60920545 T/C cg06026331 chr20:60912101 LAMA5 0.38 5.74 0.3 2.12e-8 Colorectal cancer;Colorectal cancer (SNP x SNP interaction); CRC cis rs889312 0.500 rs702691 chr5:56114526 T/G cg20203395 chr5:56204925 C5orf35 -0.41 -5.74 -0.3 2.2e-8 Breast cancer;Breast cancer (early onset); CRC cis rs704795 0.836 rs1083865 chr2:27620827 A/G cg02592271 chr2:27665507 KRTCAP3 -0.27 -6.23 -0.32 1.44e-9 Menopause (age at onset); CRC cis rs1008375 0.966 rs2010053 chr4:17583806 A/C cg02297831 chr4:17616191 MED28 0.45 5.82 0.31 1.41e-8 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs9399135 0.935 rs949547 chr6:135343499 C/G cg24558204 chr6:135376177 HBS1L 0.52 8.23 0.41 4.52e-15 Red blood cell count; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg04213235 chr1:145826932 GPR89A 0.48 6.85 0.35 3.65e-11 Intelligence (multi-trait analysis); CRC cis rs9910055 0.659 rs3826412 chr17:42255097 A/G cg13607699 chr17:42295918 UBTF 0.46 6.48 0.34 3.44e-10 Total body bone mineral density; CRC cis rs832540 0.931 rs33318 chr5:56208414 G/T cg18230493 chr5:56204884 C5orf35 -0.4 -5.92 -0.31 8.08e-9 Coronary artery disease; CRC cis rs7552404 0.924 rs114752222 chr1:76180878 C/T cg22875332 chr1:76189707 ACADM 0.77 11.24 0.53 5.2e-25 Blood metabolite levels;Acylcarnitine levels; CRC cis rs12477438 0.798 rs2084987 chr2:99587885 C/T cg14399236 chr2:99771627 LIPT1;TSGA10 -0.73 -10.32 -0.49 8.33e-22 Chronic sinus infection; CRC cis rs1552244 0.515 rs7613004 chr3:9999913 A/C cg02579736 chr3:10068473 FANCD2;CIDECP 0.65 9.23 0.45 3.51e-18 Alzheimer's disease; CRC cis rs4862750 0.872 rs6811569 chr4:187897988 A/G cg03452623 chr4:187889614 NA 0.92 21.19 0.76 1.96e-63 Lobe attachment (rater-scored or self-reported); CRC cis rs6540559 0.673 rs17015309 chr1:210007218 C/T cg22029157 chr1:209979665 IRF6 0.68 7.77 0.39 1.02e-13 Cleft lip with or without cleft palate; CRC cis rs7727544 0.647 rs72793280 chr5:131562900 C/T cg18758796 chr5:131593413 PDLIM4 0.36 6.27 0.33 1.13e-9 Blood metabolite levels; CRC cis rs9443645 0.901 rs9361460 chr6:79589467 C/G cg11833968 chr6:79620685 NA -0.36 -6.26 -0.33 1.23e-9 Intelligence (multi-trait analysis); CRC cis rs72627509 0.904 rs58408429 chr4:57769824 T/C cg26694713 chr4:57773883 REST 0.47 5.77 0.3 1.83e-8 Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); CRC cis rs826838 1.000 rs12366971 chr12:38737687 T/G cg13010199 chr12:38710504 ALG10B 0.49 6.44 0.33 4.32e-10 Heart rate; CRC cis rs9463078 0.764 rs1854547 chr6:44912366 G/A cg25276700 chr6:44698697 NA -0.27 -6.47 -0.34 3.5e-10 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; CRC cis rs1799949 0.896 rs8176086 chr17:41274778 G/A cg23758822 chr17:41437982 NA 0.79 13.4 0.59 5.55e-33 Menopause (age at onset); CRC cis rs3849570 1.000 rs11711331 chr3:81819040 A/G cg07356753 chr3:81810745 GBE1 0.72 10.95 0.52 5.38e-24 Waist circumference;Body mass index; CRC cis rs1046896 0.739 rs28459016 chr17:80741194 G/A cg19046167 chr17:80928561 B3GNTL1 0.42 5.9 0.31 9.16e-9 Glycated hemoglobin levels; CRC cis rs4423214 0.840 rs1792231 chr11:71182681 G/A cg13043300 chr11:71146211 DHCR7 -0.44 -5.98 -0.31 5.98e-9 Vitamin D levels; CRC cis rs7617773 0.925 rs34513961 chr3:48173653 T/C cg11946769 chr3:48343235 NME6 0.7 8.91 0.44 3.64e-17 Coronary artery disease; CRC cis rs2180341 1.000 rs9321073 chr6:127609691 C/T cg27446573 chr6:127587934 RNF146 0.99 14.76 0.63 3.48e-38 Breast cancer; CRC cis rs1862618 0.671 rs2591957 chr5:56243146 A/T cg12311346 chr5:56204834 C5orf35 0.64 9.6 0.47 2.18e-19 Initial pursuit acceleration; CRC cis rs2456568 0.564 rs7119708 chr11:93626641 T/C cg26875233 chr11:93583750 C11orf90 0.35 6.62 0.34 1.43e-10 Response to serotonin reuptake inhibitors in major depressive disorder; CRC trans rs8073060 0.586 rs226087 chr17:34017652 T/C cg19694781 chr19:47549865 TMEM160 -1.06 -14.24 -0.62 3.54e-36 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; CRC cis rs34172651 0.917 rs17771137 chr16:24792242 G/A cg00339695 chr16:24857497 SLC5A11 0.28 6.19 0.32 1.82e-9 Intelligence (multi-trait analysis); CRC cis rs1801251 1.000 rs13035829 chr2:233604487 A/T cg25237894 chr2:233734115 C2orf82 0.5 8.19 0.41 5.92e-15 Coronary artery disease; CRC cis rs3617 0.625 rs2245647 chr3:52862753 A/G cg18099408 chr3:52552593 STAB1 -0.35 -6.13 -0.32 2.46e-9 Red blood cell count;Autism spectrum disorder or schizophrenia; CRC cis rs9649213 0.537 rs6465663 chr7:97918883 C/G cg21770322 chr7:97807741 LMTK2 0.55 9.29 0.46 2.16e-18 Prostate cancer (SNP x SNP interaction); CRC cis rs4731207 0.698 rs7782327 chr7:124505951 C/T cg23710748 chr7:124431027 NA -0.38 -6.08 -0.32 3.42e-9 Cutaneous malignant melanoma; CRC cis rs7591163 1.000 rs2396499 chr2:228724368 C/T cg20647610 chr2:228736258 WDR69 0.46 6.16 0.32 2.16e-9 Blood pressure; CRC cis rs9534288 0.797 rs7990238 chr13:46578379 T/C cg15192986 chr13:46630673 CPB2 -0.67 -9.85 -0.48 3.16e-20 Blood protein levels; CRC cis rs7589728 0.514 rs78204719 chr2:88460747 G/C cg07952391 chr2:88470173 THNSL2 0.67 6.85 0.35 3.54e-11 Plasma clusterin levels; CRC cis rs9443645 0.901 rs9448580 chr6:79551812 C/G cg05283184 chr6:79620031 NA -0.56 -9.02 -0.45 1.61e-17 Intelligence (multi-trait analysis); CRC cis rs947211 1.000 rs947211 chr1:205752665 A/G cg14893161 chr1:205819251 PM20D1 0.45 6.35 0.33 7.27e-10 Parkinson's disease; CRC cis rs4969178 0.965 rs3817295 chr17:76394526 T/A cg20026190 chr17:76395443 PGS1 0.4 6.22 0.32 1.53e-9 HDL cholesterol levels; CRC cis rs60843830 0.661 rs6755432 chr2:106692 T/C cg00108164 chr2:264199 ACP1;SH3YL1 0.43 6.0 0.31 5.29e-9 Spherical equivalent (joint analysis main effects and education interaction); CRC cis rs853679 0.760 rs9357067 chr6:28210293 C/G cg06470822 chr6:28175283 NA 0.76 8.05 0.41 1.49e-14 Depression; CRC cis rs7044106 0.791 rs4617229 chr9:123480696 A/G cg14255062 chr9:123606675 PSMD5;LOC253039 0.48 7.49 0.38 6.5e-13 Hip circumference adjusted for BMI; CRC cis rs763121 0.925 rs17032 chr22:39130843 C/G cg06544989 chr22:39130855 UNC84B 0.52 8.47 0.42 8.23e-16 Menopause (age at onset); CRC cis rs798766 1.000 rs1665362 chr4:1726367 T/A cg02089348 chr4:1724449 TMEM129;TACC3 -0.39 -5.76 -0.3 1.94e-8 Bladder cancer;Urinary bladder cancer; CRC cis rs860295 0.702 rs5005770 chr1:155345043 C/T cg02153340 chr1:155202674 NA 0.56 6.68 0.35 1.03e-10 Body mass index; CRC cis rs11098499 0.863 rs11723090 chr4:120490592 T/C cg24375607 chr4:120327624 NA 0.51 7.54 0.38 4.72e-13 Corneal astigmatism; CRC cis rs11212617 0.905 rs172927 chr11:108124299 G/A cg12106634 chr11:108092400 ATM;NPAT 0.4 5.78 0.3 1.73e-8 Response to metformin in type 2 diabetes (glycemic); CRC cis rs847577 0.832 rs1799068 chr7:97707069 G/T cg21770322 chr7:97807741 LMTK2 -0.69 -12.5 -0.57 1.3e-29 Breast cancer; CRC cis rs7223966 1.000 rs12325866 chr17:61755974 G/A cg23090583 chr17:61904693 PSMC5;FTSJ3 0.48 6.08 0.32 3.33e-9 Hip circumference adjusted for BMI;Body mass index; CRC cis rs7618915 0.547 rs2286800 chr3:52778051 C/T cg15147215 chr3:52552868 STAB1 -0.61 -10.04 -0.48 7.46e-21 Bipolar disorder; CRC cis rs2949837 0.581 rs2960434 chr7:45972977 A/G cg15898840 chr7:45960834 IGFBP3 0.43 7.07 0.36 9.17e-12 Sitting height ratio; CRC cis rs6121246 0.909 rs6060923 chr20:30336655 A/C cg13852791 chr20:30311386 BCL2L1 0.67 10.95 0.52 5.48e-24 Mean corpuscular hemoglobin; CRC trans rs2303319 0.504 rs12467625 chr2:162603387 C/A cg22902534 chr3:183892754 AP2M1 -0.7 -6.1 -0.32 2.96e-9 Cognitive function; CRC cis rs9902453 0.868 rs8066731 chr17:28523121 T/C cg26525008 chr17:28256777 EFCAB5;SSH2 0.67 10.84 0.51 1.24e-23 Coffee consumption (cups per day); CRC cis rs7737355 0.947 rs11750739 chr5:130911743 C/T cg25547332 chr5:131281432 NA 0.37 5.73 0.3 2.28e-8 Life satisfaction; CRC cis rs72634258 0.945 rs12736494 chr1:8136016 G/A cg26816564 chr1:7831052 VAMP3 0.6 6.36 0.33 6.59e-10 Inflammatory bowel disease; CRC cis rs910316 0.934 rs7141705 chr14:75655352 G/C cg03030879 chr14:75389066 RPS6KL1 0.45 6.9 0.36 2.67e-11 Height; CRC cis rs720844 0.748 rs7606475 chr2:149325251 C/T cg09247360 chr2:149335327 NA -0.58 -6.56 -0.34 2.03e-10 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs2227564 0.729 rs2633303 chr10:75645882 G/T cg00564723 chr10:75632066 CAMK2G -0.34 -7.86 -0.4 5.47e-14 Crohn's disease;Inflammatory bowel disease; CRC cis rs7412746 0.658 rs6669855 chr1:150861229 C/T cg15448220 chr1:150897856 SETDB1 0.55 7.73 0.39 1.31e-13 Melanoma; CRC cis rs798554 0.836 rs798526 chr7:2775542 G/C cg13628971 chr7:2884303 GNA12 0.52 7.26 0.37 2.87e-12 Height; CRC cis rs9393777 0.546 rs35589403 chr6:27219491 C/G cg12292205 chr6:26970375 C6orf41 -0.82 -9.04 -0.45 1.39e-17 Intelligence (multi-trait analysis); CRC cis rs453301 0.686 rs1045527 chr8:8890041 A/G cg06636001 chr8:8085503 FLJ10661 -0.47 -7.08 -0.36 8.66e-12 Joint mobility (Beighton score); CRC cis rs3733585 0.673 rs6843873 chr4:9958788 A/C cg00071950 chr4:10020882 SLC2A9 -0.55 -9.72 -0.47 8.24e-20 Cleft plate (environmental tobacco smoke interaction); CRC cis rs3008870 1.000 rs3008854 chr1:67385951 T/C cg08660285 chr1:67390436 MIER1;WDR78 1.04 16.07 0.66 2.57e-43 Lymphocyte percentage of white cells; CRC cis rs904251 0.523 rs10947675 chr6:37479972 G/A cg25019722 chr6:37503610 NA -0.42 -7.37 -0.38 1.4e-12 Cognitive performance; CRC cis rs7089973 0.872 rs35010779 chr10:116631816 A/C cg03647239 chr10:116582469 FAM160B1 0.41 5.62 0.3 4.06e-8 Bipolar disorder or attention deficit hyperactivity disorder; CRC cis rs7617773 0.746 rs6796343 chr3:48282021 C/A cg11946769 chr3:48343235 NME6 0.73 9.86 0.48 2.87e-20 Coronary artery disease; CRC cis rs9311474 0.597 rs13303 chr3:52558008 T/C cg01758942 chr3:52551074 STAB1 0.29 5.64 0.3 3.72e-8 Electroencephalogram traits; CRC cis rs473651 0.935 rs477041 chr2:239355995 C/G cg21699342 chr2:239360505 ASB1 -0.58 -10.53 -0.5 1.58e-22 Multiple system atrophy; CRC cis rs6582630 0.519 rs7305545 chr12:38349223 G/A cg13010199 chr12:38710504 ALG10B 0.47 6.3 0.33 9.67e-10 Drug-induced liver injury (flucloxacillin); CRC cis rs9847710 0.967 rs2581778 chr3:53055311 G/A cg04503182 chr3:53078218 SFMBT1 0.42 6.63 0.34 1.42e-10 Ulcerative colitis; CRC trans rs12940923 0.935 rs11871743 chr17:56368825 A/C cg16900910 chr15:72789182 ARIH1 0.52 5.97 0.31 6.14e-9 Circulating myeloperoxidase levels (plasma); CRC cis rs17345786 0.628 rs11718446 chr3:101552553 C/T cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.55 6.94 0.36 2.1e-11 Colonoscopy-negative controls vs population controls; CRC trans rs875971 0.660 rs2191268 chr7:66110224 C/T cg21587861 chr12:32260103 BICD1 -0.37 -6.04 -0.32 4.18e-9 Aortic root size; CRC cis rs6585424 1.000 rs12777867 chr10:81935530 C/T cg11900509 chr10:81946545 ANXA11 -0.76 -9.31 -0.46 1.92e-18 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs3785574 0.962 rs58131426 chr17:61854375 T/C cg06601766 chr17:61851465 DDX42;CCDC47 0.6 8.6 0.43 3.27e-16 Height; CRC trans rs2736345 0.788 rs998683 chr8:11353000 A/G cg06636001 chr8:8085503 FLJ10661 -0.47 -5.99 -0.31 5.61e-9 Sjögren's syndrome;Systemic lupus erythematosus; CRC cis rs67311347 1.000 rs7628247 chr3:40512682 G/T cg09455208 chr3:40491958 NA -0.48 -9.47 -0.46 5.85e-19 Renal cell carcinoma; CRC cis rs2275731 0.505 rs7910712 chr10:16479256 T/C cg04254609 chr10:16479192 PTER -0.58 -8.65 -0.43 2.23e-16 Bone fracture in osteoporosis; CRC cis rs7677751 0.806 rs7678144 chr4:55102425 T/C cg00691999 chr4:55094011 PDGFRA 0.41 5.95 0.31 6.68e-9 Corneal astigmatism; CRC cis rs2952156 0.920 rs8078228 chr17:37834998 C/T cg20243544 chr17:37824526 PNMT 0.55 8.95 0.44 2.66e-17 Asthma; CRC cis rs868943 0.714 rs13193683 chr6:116356235 A/T cg15226275 chr6:116381976 FRK 0.31 7.17 0.37 4.94e-12 Total cholesterol levels; CRC cis rs3096299 0.728 rs1011749 chr16:89510869 G/C cg00750074 chr16:89608354 SPG7 -0.52 -7.9 -0.4 4.09e-14 Multiple myeloma (IgH translocation); CRC cis rs7772486 0.754 rs6570708 chr6:145989428 C/T cg23711669 chr6:146136114 FBXO30 -0.72 -12.07 -0.55 5.21e-28 Lobe attachment (rater-scored or self-reported); CRC cis rs950169 0.544 rs62021193 chr15:85170583 C/G cg11189052 chr15:85197271 WDR73 0.64 9.35 0.46 1.38e-18 Schizophrenia; CRC trans rs1005277 0.522 rs289649 chr10:37975384 T/C cg27523141 chr10:43048294 ZNF37B 0.43 6.16 0.32 2.11e-9 Extrinsic epigenetic age acceleration; CRC cis rs853679 0.760 rs9368563 chr6:28208558 A/G cg12273811 chr6:28175739 NA 0.55 5.86 0.31 1.12e-8 Depression; CRC cis rs4665809 0.556 rs10221814 chr2:26442759 C/T cg25036284 chr2:26402008 FAM59B -0.65 -8.57 -0.43 4.22e-16 Gut microbiome composition (summer); CRC cis rs7020830 0.898 rs308521 chr9:37367094 T/C cg14294708 chr9:37120828 ZCCHC7 1.0 18.22 0.71 9.07e-52 Schizophrenia; CRC cis rs9443645 0.901 rs4421161 chr6:79564219 A/G cg11833968 chr6:79620685 NA 0.33 5.77 0.3 1.85e-8 Intelligence (multi-trait analysis); CRC cis rs35306767 0.953 rs12259338 chr10:969377 C/T cg20503657 chr10:835505 NA 0.77 9.86 0.48 2.89e-20 Eosinophil percentage of granulocytes; CRC cis rs12745968 0.561 rs10874726 chr1:93103099 A/T cg17283838 chr1:93427260 FAM69A -0.48 -6.46 -0.34 3.87e-10 Bipolar disorder and schizophrenia; CRC cis rs7191439 0.728 rs4238687 chr16:88788903 T/G cg02389323 chr16:88786976 FAM38A 0.95 8.44 0.42 1.01e-15 Plateletcrit; CRC cis rs477895 0.713 rs882146 chr11:63976699 G/A cg19465662 chr11:63993652 NUDT22;TRPT1 0.76 9.29 0.46 2.2e-18 Mean platelet volume; CRC cis rs1862618 0.853 rs252898 chr5:56188931 T/C cg03609598 chr5:56110824 MAP3K1 -0.87 -10.18 -0.49 2.47e-21 Initial pursuit acceleration; CRC cis rs11764590 0.694 rs6977161 chr7:2099361 T/C cg23422044 chr7:1970798 MAD1L1 -0.41 -5.67 -0.3 3.07e-8 Neuroticism; CRC cis rs6541297 1.000 rs4846839 chr1:230284924 A/G cg05784532 chr1:230284198 GALNT2 0.43 5.79 0.3 1.66e-8 Coronary artery disease; CRC cis rs11122272 0.735 rs2749708 chr1:231529610 G/A cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.58 -8.75 -0.43 1.1e-16 Hemoglobin concentration; CRC cis rs9470366 0.545 rs2395655 chr6:36645696 C/T cg08179530 chr6:36648295 CDKN1A -0.82 -14.22 -0.62 4.33e-36 QRS duration; CRC cis rs908922 0.651 rs4845444 chr1:152530125 G/A cg09873164 chr1:152488093 CRCT1 0.4 6.72 0.35 7.83e-11 Hair morphology; CRC cis rs57221529 0.766 rs72703026 chr5:572383 G/A cg17948913 chr5:572064 NA 0.56 6.38 0.33 6e-10 Lung disease severity in cystic fibrosis; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg05342987 chr14:59655273 DAAM1 0.39 6.26 0.33 1.18e-9 Liver disease severity in Alagille syndrome; CRC cis rs7119 0.651 rs12905044 chr15:77846215 G/A cg27398640 chr15:77910606 LINGO1 -0.41 -6.85 -0.35 3.59e-11 Type 2 diabetes; CRC cis rs9372498 0.536 rs72952761 chr6:118866758 A/C cg01339444 chr6:118972232 C6orf204 0.53 6.03 0.32 4.29e-9 Diastolic blood pressure; CRC cis rs727505 0.866 rs73227503 chr7:124721044 A/G cg23710748 chr7:124431027 NA -0.72 -12.33 -0.56 5.81e-29 Lewy body disease; CRC cis rs9916302 0.629 rs9972882 chr17:37807698 A/C cg00129232 chr17:37814104 STARD3 -0.67 -11.01 -0.52 3.35e-24 Glomerular filtration rate (creatinine); CRC cis rs763014 0.966 rs15564 chr16:677854 G/T cg03804128 chr16:635623 NA 0.3 7.0 0.36 1.43e-11 Height; CRC cis rs514406 0.792 rs481440 chr1:53344976 C/T cg25767906 chr1:53392781 SCP2 -0.47 -7.27 -0.37 2.66e-12 Monocyte count; CRC cis rs4964805 0.612 rs11111758 chr12:104161084 A/G cg02344784 chr12:104178138 NT5DC3 0.47 7.27 0.37 2.64e-12 Attention deficit hyperactivity disorder; CRC trans rs1656966 1.000 rs1656966 chr3:186466252 C/T cg16245339 chr16:451507 DECR2 0.4 6.2 0.32 1.66e-9 Myopia (pathological); CRC cis rs1707322 0.686 rs2991987 chr1:46081422 C/G cg03146154 chr1:46216737 IPP -0.68 -9.7 -0.47 9.86e-20 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs780096 0.526 rs72819536 chr2:27682850 G/T cg24768116 chr2:27665128 KRTCAP3 -0.35 -7.66 -0.39 2.03e-13 Total body bone mineral density; CRC cis rs7618915 0.547 rs11177 chr3:52721305 G/A cg15147215 chr3:52552868 STAB1 -0.63 -10.34 -0.5 7.06e-22 Bipolar disorder; CRC trans rs6703335 0.870 rs10803142 chr1:243598234 A/G cg24760647 chr2:220408209 TMEM198;CHPF 0.43 6.03 0.32 4.4e-9 Schizophrenia;Schizophrenia, schizoaffective disorder or bipolar disorder; CRC cis rs642803 0.613 rs489574 chr11:65542739 C/T cg27068330 chr11:65405492 SIPA1 0.43 5.62 0.3 4.16e-8 Urate levels; CRC cis rs951366 0.789 rs1772148 chr1:205704580 A/T cg24503407 chr1:205819492 PM20D1 0.81 12.46 0.57 1.79e-29 Menarche (age at onset); CRC cis rs7927592 0.913 rs7109294 chr11:68332093 A/G cg16797656 chr11:68205561 LRP5 0.37 5.85 0.31 1.18e-8 Total body bone mineral density; CRC cis rs10751667 0.643 rs6597970 chr11:928669 C/A cg06064525 chr11:970664 AP2A2 -0.32 -6.36 -0.33 6.67e-10 Alzheimer's disease (late onset); CRC trans rs11098499 0.954 rs12506546 chr4:120301618 T/C cg25214090 chr10:38739885 LOC399744 0.63 9.84 0.48 3.36e-20 Corneal astigmatism; CRC cis rs870825 0.616 rs7680639 chr4:185652915 C/T cg07424746 chr4:185654737 MLF1IP 0.51 5.69 0.3 2.8e-8 Blood protein levels; CRC cis rs2067615 0.507 rs11113083 chr12:107073316 C/A cg15890332 chr12:107067104 RFX4 0.32 5.71 0.3 2.58e-8 Heart rate; CRC cis rs2976388 0.566 rs2585146 chr8:143798641 A/C cg22687807 chr8:143858763 LYNX1 0.5 8.1 0.41 1.1e-14 Urinary tract infection frequency; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg01479122 chr15:32163262 NA 0.42 6.26 0.33 1.19e-9 Response to antipsychotic treatment; CRC cis rs2075371 0.835 rs1646724 chr7:134001875 T/G cg20476274 chr7:133979776 SLC35B4 0.74 12.94 0.58 2.94e-31 Mean platelet volume; CRC cis rs10089 1.000 rs10064357 chr5:127417272 A/G cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.74 10.65 0.51 6.09e-23 Ileal carcinoids; CRC cis rs950169 0.580 rs1061737 chr15:85183790 G/C cg11189052 chr15:85197271 WDR73 0.65 9.37 0.46 1.23e-18 Schizophrenia; CRC cis rs992157 0.560 rs6436047 chr2:219108913 A/C cg04880052 chr2:219191631 PNKD 0.41 6.69 0.35 9.86e-11 Colorectal cancer; CRC cis rs9322193 0.923 rs2297930 chr6:150039496 T/C cg05861140 chr6:150128134 PCMT1 -0.36 -5.85 -0.31 1.18e-8 Lung cancer; CRC cis rs7223966 1.000 rs9903903 chr17:61762044 A/G cg23903597 chr17:61704154 MAP3K3 -0.43 -5.85 -0.31 1.19e-8 Hip circumference adjusted for BMI;Body mass index; CRC cis rs1395 0.744 rs4665962 chr2:27515105 A/G cg23587288 chr2:27483067 SLC30A3 -0.44 -6.54 -0.34 2.37e-10 Blood metabolite levels; CRC cis rs6938 0.514 rs56338926 chr15:75259335 C/A cg18612461 chr15:75251733 NA 0.48 7.22 0.37 3.64e-12 Breast cancer; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg01557667 chr22:43411403 NA 0.42 6.12 0.32 2.68e-9 Intelligence (multi-trait analysis); CRC cis rs7739232 0.920 rs77985073 chr6:53526949 C/A cg15658676 chr6:53530538 KLHL31 -0.76 -5.9 -0.31 8.9e-9 Hip circumference adjusted for BMI; CRC cis rs57221529 0.664 rs72704802 chr5:554211 C/T cg09021430 chr5:549028 NA -0.71 -7.84 -0.4 6.33e-14 Lung disease severity in cystic fibrosis; CRC cis rs10131894 0.635 rs174997 chr14:75434806 G/A cg03030879 chr14:75389066 RPS6KL1 0.4 6.11 0.32 2.88e-9 Coronary artery disease; CRC cis rs12893668 0.572 rs7148857 chr14:104143237 C/G cg08213375 chr14:104286397 PPP1R13B 0.43 6.83 0.35 4.21e-11 Reticulocyte count; CRC cis rs2836974 0.526 rs418359 chr21:40536734 T/C cg17971929 chr21:40555470 PSMG1 -0.72 -11.34 -0.53 2.27e-25 Cognitive function; CRC cis rs4604732 0.578 rs12036417 chr1:247624805 T/C cg12758973 chr1:247694275 LOC148824;OR2C3 0.42 6.14 0.32 2.32e-9 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CRC cis rs7493 0.853 rs35686517 chr7:95052611 G/A cg01874867 chr7:94954059 PON1 -0.52 -6.46 -0.34 3.79e-10 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs7224685 0.501 rs1878332 chr17:3904446 G/A cg11204139 chr17:3907470 NA 0.82 16.34 0.67 2.35e-44 Type 2 diabetes; CRC cis rs2811415 0.597 rs6770188 chr3:127754676 A/G cg13719885 chr3:127795394 NA -0.4 -6.06 -0.32 3.65e-9 Lung function (FEV1/FVC); CRC cis rs3771570 0.901 rs62190410 chr2:242410621 C/T cg21155796 chr2:242212141 HDLBP 0.63 6.8 0.35 5.04e-11 Prostate cancer; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg04742505 chr7:72936528 BAZ1B 0.48 6.85 0.35 3.62e-11 Response to antipsychotic treatment; CRC cis rs875971 0.798 rs7789615 chr7:65878661 A/G cg00343986 chr7:65444356 GUSB 0.45 6.22 0.32 1.52e-9 Aortic root size; CRC cis rs9300255 0.679 rs12817892 chr12:123728702 G/A cg00376283 chr12:123451042 ABCB9 -0.55 -6.16 -0.32 2.11e-9 Neutrophil percentage of white cells; CRC cis rs7659604 1.000 rs7689714 chr4:122665943 T/A cg19748678 chr4:122722346 EXOSC9 0.56 8.9 0.44 3.69e-17 Type 2 diabetes; CRC cis rs881375 0.867 rs10818484 chr9:123661194 C/T cg14255062 chr9:123606675 PSMD5;LOC253039 0.42 6.07 0.32 3.48e-9 Rheumatoid arthritis; CRC cis rs61160187 0.582 rs62372134 chr5:60202247 A/T cg16298547 chr5:60138761 ELOVL7 -0.28 -5.93 -0.31 7.59e-9 Educational attainment (years of education);Educational attainment (college completion); CRC cis rs12477438 0.765 rs6749059 chr2:99591021 G/C cg14399236 chr2:99771627 LIPT1;TSGA10 -0.75 -10.57 -0.5 1.08e-22 Chronic sinus infection; CRC trans rs16846053 0.579 rs57887363 chr2:162588720 C/T cg20749769 chr11:130029961 ST14 -0.7 -6.03 -0.32 4.32e-9 Blood osmolality (transformed sodium); CRC cis rs12142240 0.628 rs56126529 chr1:46808860 C/T cg14993813 chr1:46806288 NSUN4 -0.49 -6.22 -0.32 1.5e-9 Menopause (age at onset); CRC cis rs7552404 0.731 rs1493367 chr1:76344011 C/A cg22875332 chr1:76189707 ACADM -0.59 -7.38 -0.38 1.3e-12 Blood metabolite levels;Acylcarnitine levels; CRC cis rs2228479 0.850 rs11644213 chr16:89837367 C/T cg06558623 chr16:89946397 TCF25 -1.08 -10.25 -0.49 1.41e-21 Skin colour saturation; CRC cis rs6840360 0.593 rs1429559 chr4:152681952 A/G cg09659197 chr4:152720779 NA 0.42 8.71 0.43 1.47e-16 Intelligence (multi-trait analysis); CRC cis rs875971 0.830 rs809025 chr7:65849819 C/G cg12463550 chr7:65579703 CRCP 0.5 6.98 0.36 1.65e-11 Aortic root size; CRC cis rs1044826 0.597 rs1017468 chr3:139145778 A/G cg15131784 chr3:139108705 COPB2 0.42 6.11 0.32 2.74e-9 Obesity-related traits; CRC cis rs2832191 0.597 rs8127842 chr21:30516461 G/A cg24692254 chr21:30365293 RNF160 -0.58 -8.49 -0.42 7.16e-16 Dental caries; CRC cis rs863345 0.625 rs12119672 chr1:158500285 G/A cg12129480 chr1:158549410 OR10X1 -0.3 -6.27 -0.33 1.12e-9 Pneumococcal bacteremia; CRC cis rs9300255 0.544 rs1727310 chr12:123660510 A/G cg00376283 chr12:123451042 ABCB9 0.58 6.58 0.34 1.81e-10 Neutrophil percentage of white cells; CRC cis rs10769966 0.515 rs2568069 chr11:8977707 G/A cg00186954 chr11:8933980 ST5;C11orf17 0.54 9.75 0.47 6.77e-20 High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; CRC cis rs7591163 1.000 rs1039665 chr2:228717392 A/G cg14329157 chr2:228736135 WDR69 -0.48 -6.55 -0.34 2.17e-10 Blood pressure; CRC cis rs1712517 0.771 rs59744322 chr10:105146692 G/T cg05636881 chr10:105038444 INA 0.46 7.92 0.4 3.8e-14 Migraine; CRC cis rs870825 0.616 rs7674952 chr4:185622327 A/C cg04058563 chr4:185651563 MLF1IP 0.72 9.38 0.46 1.12e-18 Blood protein levels; CRC cis rs4555082 0.834 rs2816651 chr14:105708470 A/G cg10792982 chr14:105748885 BRF1 0.37 6.3 0.33 9.82e-10 Mean platelet volume;Platelet distribution width; CRC cis rs7659604 0.539 rs2221628 chr4:122795361 G/A cg19748678 chr4:122722346 EXOSC9 0.65 10.2 0.49 2.12e-21 Type 2 diabetes; CRC cis rs1005277 0.540 rs2145487 chr10:38010077 A/G cg00409905 chr10:38381863 ZNF37A -0.64 -10.64 -0.51 6.64e-23 Extrinsic epigenetic age acceleration; CRC cis rs7312774 0.748 rs4964191 chr12:107306497 G/A cg16260113 chr12:107380972 MTERFD3 0.74 7.49 0.38 6.43e-13 Severe influenza A (H1N1) infection; CRC cis rs3736594 0.879 rs4666011 chr2:27980912 G/C cg27432699 chr2:27873401 GPN1 0.57 7.37 0.38 1.37e-12 Fasting blood glucose;Fasting blood glucose (BMI interaction); CRC cis rs4319547 0.586 rs7956480 chr12:122817507 A/G cg05707623 chr12:122985044 ZCCHC8 -0.69 -8.43 -0.42 1.09e-15 Body mass index; CRC trans rs6550704 0.687 rs9865314 chr3:22634337 A/G cg02564756 chr3:128902977 CNBP -0.44 -6.4 -0.33 5.41e-10 Daytime sleep phenotypes; CRC cis rs78456975 1.000 rs13429866 chr2:1555211 C/A cg26248373 chr2:1572462 NA -0.66 -7.1 -0.36 7.65e-12 Placebo response in major depressive disorder (% change in symptom score); CRC cis rs1862618 0.853 rs252909 chr5:56121131 T/C cg12311346 chr5:56204834 C5orf35 -0.75 -9.81 -0.48 4.16e-20 Initial pursuit acceleration; CRC cis rs7216064 1.000 rs12602655 chr17:65909442 A/G cg12091567 chr17:66097778 LOC651250 -0.67 -7.66 -0.39 2.12e-13 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CRC cis rs7246967 0.611 rs62120457 chr19:22958519 A/G cg08271804 chr19:22816896 ZNF492 0.38 5.87 0.31 1.08e-8 Bronchopulmonary dysplasia; CRC cis rs2276314 0.857 rs28791905 chr18:33602213 G/A cg19628046 chr18:33552617 C18orf21 0.49 6.27 0.33 1.12e-9 Endometriosis;Drug-induced torsades de pointes; CRC cis rs66573146 0.561 rs67245546 chr4:6947164 T/C cg00086871 chr4:6988644 TBC1D14 0.88 7.52 0.38 5.39e-13 Granulocyte percentage of myeloid white cells; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg18585273 chr17:66197086 NA 0.43 6.22 0.32 1.51e-9 Intelligence (multi-trait analysis); CRC cis rs11123610 0.520 rs59726279 chr2:3718655 A/G cg25251562 chr2:3704773 ALLC -0.49 -6.12 -0.32 2.62e-9 Response to inhaled corticosteroid treatment in asthma (change in FEV1); CRC cis rs7615952 0.641 rs6438951 chr3:125696999 A/G cg06494592 chr3:125709126 NA -0.55 -6.76 -0.35 6.31e-11 Blood pressure (smoking interaction); CRC cis rs10504229 0.906 rs58251024 chr8:58172259 G/C cg24829409 chr8:58192753 C8orf71 -0.68 -11.34 -0.53 2.27e-25 Developmental language disorder (linguistic errors); CRC cis rs896854 0.654 rs1453377 chr8:95969947 C/T cg13393036 chr8:95962371 TP53INP1 -0.49 -8.48 -0.42 7.83e-16 Type 2 diabetes; CRC cis rs8180040 0.654 rs11714373 chr3:47214817 G/A cg10298567 chr3:47292165 KIF9 0.4 6.32 0.33 8.5e-10 Colorectal cancer; CRC cis rs4638749 0.677 rs7595399 chr2:108835943 C/G cg25838818 chr2:108905173 SULT1C2 -0.34 -5.72 -0.3 2.33e-8 Blood pressure; CRC cis rs425277 0.628 rs262662 chr1:2085033 A/G cg04315214 chr1:2043799 PRKCZ -0.38 -6.41 -0.33 5e-10 Height; CRC cis rs4713118 0.527 rs36042294 chr6:27720712 C/G cg26587870 chr6:27730563 NA -0.38 -5.95 -0.31 6.72e-9 Parkinson's disease; CRC cis rs2404602 0.583 rs4381566 chr15:76589262 A/G cg26408565 chr15:76604113 ETFA -0.36 -5.76 -0.3 1.88e-8 Blood metabolite levels; CRC cis rs7909074 0.766 rs5000415 chr10:45383674 C/T cg05187965 chr10:45406764 TMEM72 -0.37 -8.58 -0.43 3.74e-16 Mean corpuscular volume; CRC cis rs7618915 0.547 rs13085331 chr3:52627486 G/C cg10802521 chr3:52805072 NEK4 -0.59 -9.1 -0.45 8.89e-18 Bipolar disorder; CRC cis rs6540556 0.859 rs1007693 chr1:209931799 C/T cg23920097 chr1:209922102 NA -0.54 -6.75 -0.35 6.81e-11 Red blood cell count; CRC cis rs3785574 0.962 rs2584630 chr17:61887561 T/A cg25654072 chr17:61904446 PSMC5;FTSJ3 0.44 5.98 0.31 5.77e-9 Height; CRC cis rs4474465 1.000 rs4945281 chr11:78188627 C/G cg27205649 chr11:78285834 NARS2 -0.48 -5.79 -0.3 1.67e-8 Alzheimer's disease (survival time); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg22836370 chr18:51751085 MBD2 0.46 6.73 0.35 7.43e-11 Intelligence (multi-trait analysis); CRC cis rs10256972 0.758 rs7799391 chr7:1082566 C/G cg03923535 chr7:1197113 ZFAND2A 0.52 7.47 0.38 7.11e-13 Longevity;Endometriosis; CRC cis rs6951245 1.000 rs79683221 chr7:1096139 A/G cg07217954 chr7:1067459 C7orf50 0.55 5.72 0.3 2.36e-8 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs7727544 0.606 rs2631360 chr5:131707429 A/G cg12564285 chr5:131593104 PDLIM4 0.32 5.85 0.31 1.17e-8 Blood metabolite levels; CRC cis rs10779751 1.000 rs7525957 chr1:11318236 C/T cg08854313 chr1:11322531 MTOR 0.7 10.05 0.48 6.48e-21 Body mass index; CRC cis rs12291225 0.679 rs10832240 chr11:14304744 C/T cg19336497 chr11:14380999 RRAS2 -0.52 -8.54 -0.43 5.08e-16 Sense of smell; CRC cis rs898097 0.585 rs9893200 chr17:80893028 A/C cg15664640 chr17:80829946 TBCD 0.48 8.0 0.4 2.12e-14 Breast cancer; CRC cis rs559928 0.606 rs7941773 chr11:63952759 C/T cg19465662 chr11:63993652 NUDT22;TRPT1 0.7 6.66 0.34 1.12e-10 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; CRC cis rs2075371 0.863 rs1421479 chr7:133949345 T/G cg20476274 chr7:133979776 SLC35B4 0.72 11.95 0.55 1.38e-27 Mean platelet volume; CRC cis rs4481887 0.893 rs10888347 chr1:248448566 T/C cg00666640 chr1:248458726 OR2T12 0.56 9.96 0.48 1.33e-20 Common traits (Other); CRC cis rs7843479 0.582 rs7818254 chr8:21798316 C/T cg16476235 chr8:21771668 DOK2 0.42 7.27 0.37 2.61e-12 Mean corpuscular volume; CRC cis rs11677416 1.000 rs1878320 chr2:113544467 T/C cg27083787 chr2:113543245 IL1A 0.42 5.86 0.31 1.12e-8 Response to antipsychotic treatment in schizophrenia (working memory); CRC cis rs875971 0.964 rs9691480 chr7:65944306 A/C cg12463550 chr7:65579703 CRCP 0.48 6.78 0.35 5.54e-11 Aortic root size; CRC cis rs6519955 0.860 rs8136098 chr22:46425646 A/G cg05468064 chr22:46423449 NA 0.47 9.47 0.46 5.48e-19 Dupuytren's disease; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg02439053 chr19:18390991 JUND 0.46 6.43 0.33 4.61e-10 Anxiety disorder; CRC cis rs2739330 0.796 rs2154594 chr22:24254055 A/G cg24846343 chr22:24311635 DDTL -0.83 -14.77 -0.63 3.1e-38 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs9486719 0.947 rs11153071 chr6:97039741 G/A cg06623918 chr6:96969491 KIAA0776 -0.82 -9.62 -0.47 1.82e-19 Migraine;Coronary artery disease; CRC cis rs896854 0.812 rs4582532 chr8:95969257 G/A cg16049864 chr8:95962084 TP53INP1 -0.64 -11.63 -0.54 2e-26 Type 2 diabetes; CRC trans rs9395066 0.527 rs12524069 chr6:44897973 C/A cg04786201 chr1:17185605 NA 0.28 5.98 0.31 5.92e-9 Height; CRC cis rs9916302 0.904 rs11869109 chr17:37518205 G/T cg07936489 chr17:37558343 FBXL20 0.79 12.16 0.56 2.3e-28 Glomerular filtration rate (creatinine); CRC cis rs5769707 0.967 rs17182154 chr22:49990470 A/G cg20744362 chr22:50050164 C22orf34 0.31 6.13 0.32 2.5e-9 Monocyte count;Monocyte percentage of white cells; CRC cis rs35110281 0.720 rs162374 chr21:44927089 T/C cg04455712 chr21:45112962 RRP1B -0.41 -7.98 -0.4 2.48e-14 Mean corpuscular volume; CRC cis rs9322193 0.566 rs6912330 chr6:150229947 A/C cg13206674 chr6:150067644 NUP43 -0.44 -5.68 -0.3 3.04e-8 Lung cancer; CRC cis rs6685188 0.920 rs6593964 chr1:205662337 G/T cg07167872 chr1:205819463 PM20D1 0.42 5.86 0.31 1.12e-8 White blood cell count (basophil);Basophil percentage of white cells; CRC cis rs6500602 0.627 rs863501 chr16:4588394 G/C cg14951292 chr16:4525986 HMOX2;NMRAL1 -0.61 -8.69 -0.43 1.78e-16 Schizophrenia; CRC cis rs172166 0.611 rs203882 chr6:28078502 G/A cg25164649 chr6:28176230 NA 0.64 8.97 0.44 2.29e-17 Cardiac Troponin-T levels; CRC cis rs10504229 0.683 rs72649187 chr8:58108320 A/G cg22535103 chr8:58192502 C8orf71 -0.68 -8.76 -0.43 1.08e-16 Developmental language disorder (linguistic errors); CRC cis rs1008375 0.902 rs7654332 chr4:17691778 A/T cg16339924 chr4:17578868 LAP3 0.47 6.31 0.33 8.96e-10 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs6502050 0.835 rs6502070 chr17:80112634 G/A cg19223190 chr17:80058835 NA 0.4 6.41 0.33 5.05e-10 Life satisfaction; CRC trans rs10411161 0.721 rs10401778 chr19:52384315 C/T cg22319618 chr22:45562946 NUP50 -0.69 -7.57 -0.39 3.9e-13 Breast cancer; CRC cis rs1799949 1.000 rs8176145 chr17:41249094 A/G cg05368731 chr17:41323189 NBR1 0.68 10.06 0.49 6.16e-21 Menopause (age at onset); CRC cis rs7208859 0.673 rs4131618 chr17:29204801 C/T cg13385521 chr17:29058706 SUZ12P 0.65 7.71 0.39 1.51e-13 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs7666738 0.791 rs7377018 chr4:99034962 C/T cg05340658 chr4:99064831 C4orf37 0.61 9.43 0.46 7.65e-19 Colonoscopy-negative controls vs population controls; CRC cis rs12760731 0.565 rs11585355 chr1:178181219 T/G cg00404053 chr1:178313656 RASAL2 1.11 11.47 0.53 7.73e-26 Obesity-related traits; CRC cis rs6432018 0.964 rs11890807 chr2:9753732 C/A cg12832956 chr2:9616023 IAH1 -0.37 -5.61 -0.3 4.24e-8 Heart rate variability traits; CRC cis rs41005 0.967 rs13430914 chr2:8114648 A/G cg03155496 chr2:8117019 LOC339788 0.4 7.08 0.36 8.77e-12 Response to anti-TNF therapy in rheumatoid arthritis; CRC cis rs17376456 1.000 rs17376456 chr5:93557702 C/T cg21475434 chr5:93447410 FAM172A -0.78 -7.27 -0.37 2.57e-12 Diabetic retinopathy; CRC cis rs2120019 0.938 rs2120020 chr15:75316845 T/C cg09165964 chr15:75287851 SCAMP5 -0.86 -13.29 -0.59 1.51e-32 Blood trace element (Zn levels); CRC cis rs9807989 0.507 rs1035129 chr2:103019785 T/C cg03938978 chr2:103052716 IL18RAP 0.59 10.17 0.49 2.54e-21 Asthma; CRC cis rs1799949 0.965 rs9646418 chr17:41425901 A/G cg23758822 chr17:41437982 NA 0.94 19.3 0.73 4.72e-56 Menopause (age at onset); CRC cis rs13191362 1.000 rs13204439 chr6:163015358 A/C cg23758597 chr6:163146217 PARK2 0.5 5.77 0.3 1.85e-8 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs875971 1.000 rs2220626 chr7:65546062 C/T cg11764359 chr7:65958608 NA -0.6 -9.55 -0.47 3.11e-19 Aortic root size; CRC cis rs611744 0.647 rs2597658 chr8:109256014 C/T cg21045802 chr8:109455806 TTC35 0.41 6.52 0.34 2.72e-10 Dupuytren's disease; CRC cis rs477895 0.653 rs2875749 chr11:63903878 C/A cg05016508 chr11:63871570 FLRT1;MACROD1 0.53 6.83 0.35 4.22e-11 Mean platelet volume; CRC cis rs4713118 0.662 rs149900 chr6:28014597 C/T cg12172441 chr6:28176163 NA 0.52 6.66 0.34 1.17e-10 Parkinson's disease; CRC cis rs3096299 0.685 rs3803682 chr16:89544636 C/T cg00750074 chr16:89608354 SPG7 -0.47 -7.25 -0.37 2.96e-12 Multiple myeloma (IgH translocation); CRC cis rs73206853 0.609 rs7306167 chr12:110892449 A/G cg12870014 chr12:110450643 ANKRD13A 0.84 9.88 0.48 2.53e-20 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC cis rs7605827 0.930 rs2058868 chr2:15679609 A/T cg19274914 chr2:15703543 NA 0.39 5.82 0.31 1.4e-8 Educational attainment (years of education); CRC cis rs7309 0.870 rs2358016 chr2:162007430 C/G cg08807892 chr2:162101083 NA -0.43 -6.32 -0.33 8.68e-10 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Educational attainment; CRC cis rs35000415 0.938 rs12535158 chr7:128625019 C/T cg19972273 chr7:128594194 NA 0.68 6.31 0.33 8.75e-10 Systemic lupus erythematosus; CRC cis rs67478160 0.608 rs11628787 chr14:104323984 G/A cg01849466 chr14:104193079 ZFYVE21 0.53 9.69 0.47 1.05e-19 Schizophrenia; CRC cis rs1799949 0.860 rs8176279 chr17:41210396 A/C cg25072359 chr17:41440525 NA 0.5 7.89 0.4 4.53e-14 Menopause (age at onset); CRC cis rs801193 0.569 rs2707824 chr7:66189243 A/G cg11764359 chr7:65958608 NA 0.59 8.85 0.44 5.44e-17 Aortic root size; CRC cis rs863345 0.604 rs10908673 chr1:158503908 T/G cg12129480 chr1:158549410 OR10X1 -0.3 -6.27 -0.33 1.12e-9 Pneumococcal bacteremia; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg16482226 chr12:70637792 CNOT2 0.45 6.34 0.33 7.67e-10 Response to antipsychotic treatment; CRC trans rs596169 0.541 rs6667536 chr1:219215137 G/A cg00778190 chr1:95068029 NA 0.75 6.5 0.34 2.89e-10 Intraocular pressure; CRC cis rs8180040 0.545 rs9311403 chr3:47138878 T/C cg10298567 chr3:47292165 KIF9 -0.4 -6.24 -0.33 1.37e-9 Colorectal cancer; CRC cis rs10489202 0.913 rs380753 chr1:168035273 G/T cg24449463 chr1:168025552 DCAF6 -0.49 -6.35 -0.33 7.27e-10 Schizophrenia; CRC cis rs4481887 0.504 rs4916109 chr1:248360659 G/A cg00666640 chr1:248458726 OR2T12 0.44 7.07 0.36 9.39e-12 Common traits (Other); CRC cis rs896854 0.738 rs2515226 chr8:95965743 G/A cg23172400 chr8:95962367 TP53INP1 0.41 6.13 0.32 2.47e-9 Type 2 diabetes; CRC cis rs4713118 0.513 rs202908 chr6:28011551 C/G cg12172441 chr6:28176163 NA 0.5 6.94 0.36 2.14e-11 Parkinson's disease; CRC cis rs2153535 0.580 rs7741403 chr6:8530578 C/T cg21535247 chr6:8435926 SLC35B3 -0.48 -7.31 -0.37 2.09e-12 Motion sickness; CRC cis rs1267303 0.642 rs116078607 chr1:46999238 G/A cg25110126 chr1:46999211 NA 0.6 8.76 0.44 1.02e-16 Monobrow; CRC cis rs7546094 0.509 rs7415988 chr1:113159730 G/T cg22162597 chr1:113214053 CAPZA1 -0.71 -9.92 -0.48 1.9e-20 Platelet distribution width; CRC trans rs66573146 0.656 rs57454756 chr4:6958582 C/T cg07817883 chr1:32538562 TMEM39B 1.46 12.99 0.58 2.01e-31 Granulocyte percentage of myeloid white cells; CRC cis rs12024301 0.557 rs77404665 chr1:183663284 A/G cg11505048 chr1:183622726 RGL1;APOBEC4 0.78 6.59 0.34 1.78e-10 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs4148883 0.651 rs10020052 chr4:100086331 C/G cg13256891 chr4:100009986 ADH5 0.42 6.09 0.32 3.07e-9 Alcohol dependence; CRC cis rs7769051 0.522 rs6934190 chr6:133116664 G/A cg22852734 chr6:133119734 C6orf192 1.03 8.02 0.4 1.93e-14 Type 2 diabetes nephropathy; CRC cis rs1215050 0.791 rs2865943 chr4:98778449 C/T cg05340658 chr4:99064831 C4orf37 0.46 6.68 0.35 1.01e-10 Waist-to-hip ratio adjusted for body mass index; CRC cis rs7954584 0.504 rs10840633 chr12:122377511 A/T cg21171335 chr12:122356390 WDR66 0.4 6.0 0.31 5.26e-9 Mean corpuscular volume; CRC cis rs1552244 0.572 rs6785976 chr3:10168647 A/G cg18598329 chr3:10140678 FANCD2;C3orf24 -0.9 -10.81 -0.51 1.64e-23 Alzheimer's disease; CRC cis rs12042938 0.622 rs12030517 chr1:231808385 T/C cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX 0.43 5.74 0.3 2.21e-8 Neuranatomic and neurocognitive phenotypes; CRC cis rs2742417 0.603 rs1962800 chr3:45779943 C/T cg04837898 chr3:45731254 SACM1L -0.46 -7.03 -0.36 1.18e-11 Response to anti-depressant treatment in major depressive disorder; CRC cis rs11098699 0.821 rs7684799 chr4:124207659 C/T cg09941581 chr4:124220074 SPATA5 0.4 5.87 0.31 1.08e-8 Mosquito bite size; CRC cis rs2842992 0.830 rs2025190 chr6:160138241 C/T cg16489826 chr6:160211363 TCP1;MRPL18 0.47 5.68 0.3 3.01e-8 Age-related macular degeneration (geographic atrophy); CRC cis rs873946 0.564 rs12263364 chr10:134555548 G/T cg26818010 chr10:134567672 INPP5A -0.56 -7.52 -0.38 5.13e-13 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CRC cis rs7202877 0.656 rs4888370 chr16:75308230 T/C cg03315344 chr16:75512273 CHST6 0.51 5.97 0.31 5.99e-9 Type 2 diabetes;Type 1 diabetes; CRC trans rs2727020 0.538 rs61885230 chr11:49128958 T/C cg15704280 chr7:45808275 SEPT13 -0.57 -8.38 -0.42 1.55e-15 Coronary artery disease; CRC cis rs2797160 1.000 rs1935772 chr6:125994708 T/C cg05901451 chr6:126070800 HEY2 -0.38 -5.86 -0.31 1.15e-8 Endometrial cancer; CRC cis rs769267 0.965 rs13964 chr19:19468710 C/G cg03709012 chr19:19516395 GATAD2A -0.71 -10.83 -0.51 1.4e-23 Tonsillectomy; CRC trans rs561341 0.740 rs11080174 chr17:30208521 C/A cg20587970 chr11:113659929 NA 0.66 8.59 0.43 3.64e-16 Hip circumference adjusted for BMI; CRC cis rs6582630 0.502 rs4309219 chr12:38293584 A/G cg13010199 chr12:38710504 ALG10B 0.47 6.6 0.34 1.64e-10 Drug-induced liver injury (flucloxacillin); CRC cis rs10256972 0.524 rs6945202 chr7:1116558 T/C cg16145915 chr7:1198662 ZFAND2A -0.33 -6.35 -0.33 7.19e-10 Longevity;Endometriosis; CRC cis rs9467711 0.606 rs9348712 chr6:26366511 T/A cg14345882 chr6:26364793 BTN3A2 0.65 5.74 0.3 2.17e-8 Autism spectrum disorder or schizophrenia; CRC cis rs3126085 0.935 rs10888467 chr1:152171707 C/T cg09127314 chr1:152161683 NA 0.53 6.59 0.34 1.7e-10 Atopic dermatitis; CRC cis rs9291683 0.538 rs11727199 chr4:10036190 C/T cg00071950 chr4:10020882 SLC2A9 0.67 12.67 0.57 3.24e-30 Bone mineral density; CRC cis rs8067545 0.578 rs4925087 chr17:20024582 A/C cg13482628 chr17:19912719 NA 0.43 6.73 0.35 7.35e-11 Schizophrenia; CRC cis rs7618915 0.547 rs34537256 chr3:52657472 A/G cg08222913 chr3:52553049 STAB1 -0.34 -6.08 -0.32 3.35e-9 Bipolar disorder; CRC cis rs9611565 0.546 rs739132 chr22:42123099 A/T cg06481639 chr22:41940642 POLR3H 0.52 5.91 0.31 8.37e-9 Vitiligo; CRC cis rs8060686 0.641 rs113704872 chr16:68032598 G/A cg08314208 chr16:67682810 RLTPR -0.65 -6.67 -0.34 1.11e-10 HDL cholesterol;Metabolic syndrome; CRC cis rs561341 1.000 rs501957 chr17:30314504 C/T cg19193384 chr17:30244184 NA -0.63 -7.36 -0.38 1.47e-12 Hip circumference adjusted for BMI; CRC cis rs72615157 0.634 rs79986079 chr7:99802044 C/T cg00814883 chr7:100076585 TSC22D4 -0.51 -6.11 -0.32 2.82e-9 Lung function (FEV1/FVC); CRC cis rs62103177 0.810 rs62103187 chr18:77627633 G/C cg12964065 chr18:77638022 KCNG2 0.66 6.69 0.35 9.58e-11 Opioid sensitivity; CRC cis rs7959452 0.640 rs4274230 chr12:69700772 T/G cg14784868 chr12:69753453 YEATS4 0.76 12.35 0.56 4.59e-29 Blood protein levels; CRC cis rs1448094 0.511 rs34885805 chr12:86155180 A/T cg06740227 chr12:86229804 RASSF9 0.38 5.7 0.3 2.73e-8 Major depressive disorder; CRC cis rs6951245 0.529 rs10262070 chr7:1141738 C/T cg03188948 chr7:1209495 NA 0.51 6.06 0.32 3.66e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC trans rs7671189 0.502 rs6833771 chr4:11746004 T/G cg18054620 chr5:111191530 C5orf13 -0.3 -6.0 -0.31 5.22e-9 Obesity-related traits; CRC cis rs4975616 0.869 rs455433 chr5:1336243 A/G cg06550200 chr5:1325588 CLPTM1L -0.74 -12.11 -0.56 3.73e-28 Lung cancer; CRC cis rs11690935 0.550 rs6718013 chr2:172869185 A/G cg13550731 chr2:172543902 DYNC1I2 0.61 8.8 0.44 7.61e-17 Schizophrenia; CRC cis rs28386778 0.897 rs896064 chr17:61860932 C/T cg23090583 chr17:61904693 PSMC5;FTSJ3 1.05 20.29 0.75 6.44e-60 Prudent dietary pattern; CRC cis rs12681287 0.547 rs10956873 chr8:87547028 T/C cg27223183 chr8:87520930 FAM82B 0.5 6.72 0.35 7.91e-11 Caudate activity during reward; CRC trans rs1814175 0.817 rs1851860 chr11:49861310 A/C cg15704280 chr7:45808275 SEPT13 -0.97 -19.07 -0.72 3.91e-55 Height; CRC cis rs10256972 0.552 rs7805591 chr7:1210745 A/G cg04025307 chr7:1156635 C7orf50 0.67 10.71 0.51 3.68e-23 Longevity;Endometriosis; CRC cis rs2836974 0.568 rs442972 chr21:40534757 C/T cg11890956 chr21:40555474 PSMG1 -0.92 -16.62 -0.68 1.91e-45 Cognitive function; CRC cis rs61160187 0.582 rs62367903 chr5:60318973 A/G cg16298547 chr5:60138761 ELOVL7 -0.27 -5.89 -0.31 9.31e-9 Educational attainment (years of education);Educational attainment (college completion); CRC trans rs561341 0.709 rs11542477 chr17:30185892 A/G cg00801512 chr17:28996047 NA 0.53 6.25 0.33 1.27e-9 Hip circumference adjusted for BMI; CRC cis rs17376456 0.877 rs10059230 chr5:93450347 A/G cg25358565 chr5:93447407 FAM172A 0.98 10.46 0.5 2.72e-22 Diabetic retinopathy; CRC cis rs11676348 1.000 rs11676348 chr2:219010146 C/T cg04731861 chr2:219085781 ARPC2 0.28 5.77 0.3 1.85e-8 Ulcerative colitis; CRC cis rs9527 0.571 rs7096249 chr10:104618524 G/A cg08772003 chr10:104629869 AS3MT -0.36 -6.11 -0.32 2.84e-9 Arsenic metabolism; CRC cis rs4478858 0.735 rs11590120 chr1:31792324 A/G cg07478791 chr1:31886160 SERINC2 -0.41 -5.67 -0.3 3.13e-8 Alcohol dependence; CRC cis rs9916302 0.904 rs4357971 chr17:37717280 C/T cg15445000 chr17:37608096 MED1 0.42 9.4 0.46 9.75e-19 Glomerular filtration rate (creatinine); CRC trans rs148734725 1 rs148734725 chr3:49406708 G/A cg21665057 chr3:196295764 WDR53;FBXO45 -0.64 -8.75 -0.43 1.1e-16 Educational attainment (college completion); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg04408576 chr16:1524927 CLCN7 0.44 7.59 0.39 3.39e-13 Liver disease severity in Alagille syndrome; CRC cis rs929354 0.772 rs2023975 chr7:157012096 G/A cg16102536 chr7:156981717 UBE3C 0.4 6.72 0.35 8.04e-11 Body mass index; CRC cis rs990171 1.000 rs12712145 chr2:103008710 T/C cg03938978 chr2:103052716 IL18RAP 0.47 5.89 0.31 9.5e-9 Lymphocyte counts; CRC cis rs7707921 1.000 rs1543911 chr5:81504841 C/T cg17942617 chr5:81327376 ATG10 -0.4 -6.01 -0.31 4.94e-9 Breast cancer; CRC cis rs11958404 0.860 rs6868830 chr5:157442187 T/C cg05962755 chr5:157440814 NA 1.01 12.62 0.57 4.62e-30 IgG glycosylation; CRC cis rs9811920 0.609 rs793463 chr3:99620252 T/C cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G 0.46 6.2 0.32 1.73e-9 Axial length; CRC cis rs1552244 0.572 rs3774208 chr3:10164722 T/G cg02579736 chr3:10068473 FANCD2;CIDECP 1.01 11.58 0.54 2.98e-26 Alzheimer's disease; CRC cis rs4073416 0.542 rs1113962 chr14:66005798 C/T cg03016385 chr14:66212404 NA -0.43 -6.06 -0.32 3.73e-9 N-glycan levels; CRC cis rs11719291 0.667 rs9877542 chr3:48748545 C/T cg00383909 chr3:49044727 WDR6 0.78 8.09 0.41 1.18e-14 Cognitive function; CRC cis rs7811142 1.000 rs66632384 chr7:100018904 G/A cg00814883 chr7:100076585 TSC22D4 -0.73 -9.37 -0.46 1.17e-18 Platelet count; CRC cis rs3806843 0.576 rs246036 chr5:140331886 T/G cg19875535 chr5:140030758 IK 0.4 6.12 0.32 2.64e-9 Depressive symptoms (multi-trait analysis); CRC cis rs12586317 0.547 rs10145723 chr14:35460954 G/A cg05294307 chr14:35346193 BAZ1A -0.73 -8.21 -0.41 5.01e-15 Psoriasis; CRC cis rs6426558 0.515 rs7543579 chr1:227377699 A/T cg10327440 chr1:227177885 CDC42BPA -0.44 -6.49 -0.34 3.22e-10 Neutrophil percentage of white cells; CRC cis rs6500395 0.963 rs2111242 chr16:48708300 T/C cg04672837 chr16:48644449 N4BP1 -0.45 -6.63 -0.34 1.38e-10 Response to tocilizumab in rheumatoid arthritis; CRC cis rs11030122 0.547 rs10835324 chr11:3954928 G/C cg18678763 chr11:4115507 RRM1 -0.39 -6.62 -0.34 1.43e-10 Mean platelet volume;Platelet distribution width; CRC trans rs2228479 0.850 rs62054609 chr16:89816569 C/A cg24644049 chr4:85504048 CDS1 0.9 7.46 0.38 7.69e-13 Skin colour saturation; CRC cis rs7208859 0.673 rs9911989 chr17:29237702 A/C cg01831904 chr17:28903510 LRRC37B2 0.57 5.89 0.31 9.58e-9 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs2976388 1.000 rs1045605 chr8:143764101 C/G cg22687807 chr8:143858763 LYNX1 -0.38 -6.68 -0.35 1.04e-10 Urinary tract infection frequency; CRC cis rs1799949 1.000 rs34572725 chr17:41428666 G/A cg01879757 chr17:41196368 BRCA1 -0.44 -6.68 -0.35 9.92e-11 Menopause (age at onset); CRC cis rs7811142 1.000 rs67471932 chr7:100009985 C/G cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.62 8.15 0.41 7.87e-15 Platelet count; CRC cis rs1448094 0.512 rs12313775 chr12:86241197 G/A cg00310523 chr12:86230176 RASSF9 0.33 5.62 0.3 3.97e-8 Major depressive disorder; CRC cis rs10256972 0.552 rs2960837 chr7:1203957 A/G cg22907277 chr7:1156413 C7orf50 0.65 10.03 0.48 7.96e-21 Longevity;Endometriosis; CRC cis rs870825 0.655 rs28726376 chr4:185638954 A/G cg04058563 chr4:185651563 MLF1IP 0.73 9.54 0.47 3.37e-19 Blood protein levels; CRC cis rs2243480 1.000 rs67728539 chr7:65378124 G/A cg18252515 chr7:66147081 NA -1.11 -12.97 -0.58 2.38e-31 Diabetic kidney disease; CRC cis rs7927592 0.763 rs624003 chr11:68231240 C/T cg01657329 chr11:68192670 LRP5 -0.54 -8.8 -0.44 7.94e-17 Total body bone mineral density; CRC cis rs3892630 0.878 rs114224536 chr19:33211232 A/G cg22980127 chr19:33182716 NUDT19 0.92 10.95 0.52 5.44e-24 Red blood cell traits; CRC trans rs1455244 0.700 rs7229302 chr18:11508904 G/T cg15377113 chr14:93799418 BTBD7;KIAA1409 0.41 6.45 0.34 3.96e-10 Schizophrenia; CRC cis rs2727020 0.553 rs4980447 chr11:49591662 T/C cg27395922 chr11:50257633 LOC441601 -0.35 -5.67 -0.3 3.08e-8 Coronary artery disease; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg10459029 chr2:242640849 ING5 0.48 7.11 0.36 7.47e-12 Intelligence (multi-trait analysis); CRC cis rs35123781 1.000 rs682164 chr5:139058589 A/G cg10513866 chr5:139070639 NA 0.47 7.54 0.38 4.77e-13 Schizophrenia; CRC cis rs2204008 0.540 rs1672425 chr12:38122842 G/A cg13010199 chr12:38710504 ALG10B -0.41 -5.93 -0.31 7.67e-9 Bladder cancer; CRC cis rs4713118 0.513 rs149878 chr6:27878738 T/G cg23161317 chr6:28129485 ZNF389 0.46 6.54 0.34 2.36e-10 Parkinson's disease; CRC cis rs11249608 0.548 rs6875473 chr5:178451387 C/A cg01312482 chr5:178451176 ZNF879 -0.37 -6.15 -0.32 2.26e-9 Pubertal anthropometrics; CRC cis rs933688 1.000 rs332544 chr5:90778848 C/T cg26981201 chr5:90679533 LOC100129716;ARRDC3 0.96 17.38 0.69 1.8e-48 Smoking behavior; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg23111772 chr20:62338704 ARFRP1;ZGPAT -0.41 -6.04 -0.32 4.24e-9 Myopia (pathological); CRC cis rs1865721 0.804 rs7229401 chr18:73148127 T/G cg26385618 chr18:73139727 C18orf62 -0.41 -5.7 -0.3 2.71e-8 Intelligence; CRC cis rs554111 0.858 rs10916855 chr1:21056382 T/C cg08890418 chr1:21044141 KIF17 0.31 5.82 0.31 1.36e-8 Facial morphology (factor 17, height of vermillion upper lip); CRC cis rs2033908 0.620 rs10765996 chr11:12853043 A/G cg25843174 chr11:12811716 TEAD1 -0.4 -7.04 -0.36 1.1e-11 Sitting height ratio; CRC cis rs9649213 0.555 rs6955259 chr7:97892356 T/A cg24562669 chr7:97807699 LMTK2 0.48 8.1 0.41 1.08e-14 Prostate cancer (SNP x SNP interaction); CRC cis rs10197940 0.545 rs2444267 chr2:152308611 T/G cg19508488 chr2:152266495 RIF1 0.46 6.62 0.34 1.43e-10 Lung cancer; CRC cis rs3806843 0.966 rs11741994 chr5:140145949 G/A cg16607685 chr5:140181889 PCDHA2;PCDHA1;PCDHA3 -0.28 -6.41 -0.33 5.1e-10 Depressive symptoms (multi-trait analysis); CRC trans rs1814175 0.817 rs4084376 chr11:49831160 T/C cg21153622 chr11:89784906 NA -0.38 -6.03 -0.32 4.45e-9 Height; CRC cis rs10504229 0.679 rs12679941 chr8:58051812 G/T cg21724239 chr8:58056113 NA 0.55 7.61 0.39 3.01e-13 Developmental language disorder (linguistic errors); CRC cis rs4713118 0.669 rs200997 chr6:27811815 G/A cg15786705 chr6:28176104 NA 0.52 7.15 0.37 5.71e-12 Parkinson's disease; CRC cis rs4819052 0.808 rs11909411 chr21:46676556 A/C cg19498844 chr21:46707878 POFUT2;LOC642852 0.78 11.23 0.53 5.38e-25 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs11785693 0.862 rs11774044 chr8:4988035 C/G cg26367366 chr8:4980734 NA 0.91 11.15 0.52 1.08e-24 Neuroticism (multi-trait analysis);Neuroticism; CRC cis rs477692 0.905 rs485579 chr10:131425492 T/G cg26102564 chr10:131424627 MGMT 0.39 5.68 0.3 2.91e-8 Response to temozolomide; CRC cis rs6543140 0.693 rs7579737 chr2:102987361 A/G cg03938978 chr2:103052716 IL18RAP 0.5 7.75 0.39 1.16e-13 Blood protein levels; CRC cis rs6582630 0.519 rs11514078 chr12:38408817 G/C cg26384229 chr12:38710491 ALG10B 0.69 9.39 0.46 1.04e-18 Drug-induced liver injury (flucloxacillin); CRC cis rs992157 0.835 rs13031757 chr2:219151926 T/C cg13835894 chr2:219148914 PNKD;TMBIM1 -0.35 -6.71 -0.35 8.58e-11 Colorectal cancer; CRC cis rs644799 0.965 rs687529 chr11:95545587 T/A cg03916912 chr11:95522834 CEP57;FAM76B 0.95 18.15 0.71 1.71e-51 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs7666738 0.830 rs6843777 chr4:98866635 T/A cg17366294 chr4:99064904 C4orf37 0.39 6.28 0.33 1.05e-9 Colonoscopy-negative controls vs population controls; CRC cis rs10504229 1.000 rs111915672 chr8:58191665 T/C cg24829409 chr8:58192753 C8orf71 -0.69 -11.17 -0.52 9.09e-25 Developmental language disorder (linguistic errors); CRC trans rs6703335 0.870 rs10803142 chr1:243598234 A/G cg01834625 chr1:151254649 ZNF687 0.45 6.22 0.32 1.51e-9 Schizophrenia;Schizophrenia, schizoaffective disorder or bipolar disorder; CRC cis rs2739330 0.796 rs5760106 chr22:24250645 A/C cg23131131 chr22:24373011 LOC391322 0.67 10.15 0.49 3.05e-21 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs9381040 0.610 rs9367094 chr6:41017860 T/C cg03644281 chr6:41068752 NFYA;LOC221442 -0.45 -6.42 -0.33 4.71e-10 Alzheimer's disease (late onset); CRC cis rs9322193 0.962 rs7740784 chr6:150154500 C/T cg13206674 chr6:150067644 NUP43 0.67 9.23 0.45 3.48e-18 Lung cancer; CRC cis rs936229 0.749 rs6495126 chr15:75175026 C/T cg10253484 chr15:75165896 SCAMP2 0.48 7.12 0.37 6.61e-12 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); CRC cis rs17401966 0.838 rs4846212 chr1:10370312 T/C cg19773385 chr1:10388646 KIF1B -0.63 -9.87 -0.48 2.66e-20 Hepatocellular carcinoma; CRC trans rs9291683 0.530 rs17246501 chr4:9985710 A/C cg26043149 chr18:55253948 FECH 0.53 8.08 0.41 1.25e-14 Bone mineral density; CRC cis rs4423214 0.840 rs1790344 chr11:71176897 A/G cg13043300 chr11:71146211 DHCR7 -0.44 -5.91 -0.31 8.58e-9 Vitamin D levels; CRC cis rs17270561 0.609 rs1892255 chr6:25750354 G/A cg17691542 chr6:26056736 HIST1H1C 0.7 8.57 0.43 4.08e-16 Iron status biomarkers; CRC trans rs1005277 0.579 rs2474595 chr10:38426782 C/G cg11292332 chr7:45801988 SEPT13 0.35 6.09 0.32 3.07e-9 Extrinsic epigenetic age acceleration; CRC cis rs4713118 0.615 rs57252182 chr6:27720249 C/A cg20933634 chr6:27740509 NA 0.45 6.63 0.34 1.34e-10 Parkinson's disease; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg12365451 chr11:33279136 HIPK3 0.44 6.26 0.33 1.22e-9 Response to antipsychotic treatment; CRC cis rs7224685 0.501 rs11650023 chr17:4012850 C/T cg21851534 chr17:3907994 ZZEF1 -0.39 -6.46 -0.34 3.7e-10 Type 2 diabetes; CRC cis rs477895 0.713 rs11601024 chr11:63943074 A/G cg18225595 chr11:63971243 STIP1 0.6 7.94 0.4 3.31e-14 Mean platelet volume; CRC cis rs12701220 0.655 rs12702117 chr7:1148702 T/C cg26240231 chr7:1148101 C7orf50 -0.46 -6.69 -0.35 9.41e-11 Bronchopulmonary dysplasia; CRC cis rs12681288 0.676 rs17740799 chr8:1014327 C/T cg04851639 chr8:1020857 NA 0.37 7.64 0.39 2.33e-13 Schizophrenia; CRC cis rs4555082 0.830 rs2735812 chr14:105727575 A/G cg06808227 chr14:105710500 BRF1 -0.62 -8.96 -0.44 2.44e-17 Mean platelet volume;Platelet distribution width; CRC cis rs7538876 1.000 rs942457 chr1:17739586 G/A cg01904812 chr1:17746340 RCC2 0.33 5.67 0.3 3.2e-8 Basal cell carcinoma; CRC cis rs7626444 0.647 rs843537 chr3:196473403 C/A cg12930392 chr3:196481615 PAK2 0.38 6.73 0.35 7.73e-11 Monocyte count; CRC cis rs3540 0.921 rs8034050 chr15:91000206 C/T cg22089800 chr15:90895588 ZNF774 0.5 7.97 0.4 2.57e-14 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; CRC cis rs9488822 0.636 rs10872142 chr6:116369052 C/A cg15226275 chr6:116381976 FRK 0.29 8.35 0.42 1.9e-15 Cholesterol, total;LDL cholesterol; CRC cis rs798766 1.000 rs11729657 chr4:1737585 T/C cg21505886 chr4:1724428 TMEM129;TACC3 -0.39 -5.62 -0.3 4.03e-8 Bladder cancer;Urinary bladder cancer; CRC cis rs3818285 0.556 rs941864 chr10:111656948 T/C cg00817464 chr10:111662876 XPNPEP1 -0.47 -6.49 -0.34 3.1e-10 Superior crus of antihelix expression; CRC cis rs10782582 0.545 rs111927462 chr1:76195422 A/G cg03433033 chr1:76189801 ACADM -0.45 -6.39 -0.33 5.72e-10 Daytime sleep phenotypes; CRC cis rs3087591 0.659 rs7218930 chr17:29640204 A/G cg24425628 chr17:29625626 OMG;NF1 0.71 13.15 0.59 4.98e-32 Hip circumference; CRC cis rs17270561 0.609 rs9358877 chr6:25739228 A/G cg17691542 chr6:26056736 HIST1H1C 0.73 9.26 0.45 2.71e-18 Iron status biomarkers; CRC cis rs2495707 0.624 rs2489008 chr10:102422934 C/T cg13834844 chr10:102415320 NA -0.35 -5.86 -0.31 1.14e-8 Body mass index; CRC cis rs897984 0.762 rs12930545 chr16:30938811 A/G cg02466173 chr16:30829666 NA 0.66 10.0 0.48 1.02e-20 Dementia with Lewy bodies; CRC cis rs1799949 1.000 rs915945 chr17:41179864 C/T cg05368731 chr17:41323189 NBR1 0.67 9.63 0.47 1.64e-19 Menopause (age at onset); CRC trans rs7618501 0.521 rs34654589 chr3:49911449 C/G cg21665057 chr3:196295764 WDR53;FBXO45 0.5 7.1 0.36 7.82e-12 Intelligence (multi-trait analysis); CRC cis rs6460942 0.591 rs80311633 chr7:12339690 G/C cg20607287 chr7:12443886 VWDE -0.55 -5.98 -0.31 5.75e-9 Coronary artery disease; CRC cis rs6951245 0.872 rs77569514 chr7:1085508 G/A cg21664854 chr7:1097933 C7orf50;GPR146 0.79 8.96 0.44 2.48e-17 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs4727027 0.704 rs7784122 chr7:148904624 A/G cg12479418 chr7:148823350 ZNF425;ZNF398 -0.41 -5.82 -0.31 1.37e-8 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC cis rs7927592 0.913 rs3740629 chr11:68343593 C/T cg01657329 chr11:68192670 LRP5 -0.47 -6.79 -0.35 5.16e-11 Total body bone mineral density; CRC trans rs2303319 0.504 rs12465734 chr2:162437859 A/G cg18122310 chr12:50236657 BCDIN3D -0.73 -6.01 -0.31 4.93e-9 Cognitive function; CRC cis rs2295359 0.892 rs72676058 chr1:67627681 C/A cg03340356 chr1:67600835 NA 0.29 6.56 0.34 2.11e-10 Psoriasis; CRC cis rs1707322 0.721 rs10157795 chr1:46228192 G/A cg03146154 chr1:46216737 IPP 0.59 8.53 0.43 5.29e-16 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs2153535 0.580 rs7775909 chr6:8477778 A/G cg07606381 chr6:8435919 SLC35B3 0.68 10.89 0.51 8.87e-24 Motion sickness; CRC cis rs854765 0.547 rs4368210 chr17:17896090 A/G cg24612305 chr17:17875800 TOM1L2;LRRC48 -0.77 -13.36 -0.59 8.2e-33 Total body bone mineral density; CRC trans rs10982213 0.830 rs2274163 chr9:117188714 C/T cg02551882 chr22:31365455 MORC2;TUG1 0.39 6.03 0.32 4.53e-9 Interleukin-6 levels; CRC cis rs929354 0.772 rs3802118 chr7:156986814 T/C cg05182265 chr7:156933206 UBE3C -0.76 -14.52 -0.62 3.01e-37 Body mass index; CRC trans rs61931739 0.500 rs7309931 chr12:34483471 A/C cg26384229 chr12:38710491 ALG10B 0.61 8.95 0.44 2.61e-17 Morning vs. evening chronotype; CRC cis rs11098499 0.954 rs878373 chr4:120237484 A/T cg09307838 chr4:120376055 NA 0.69 10.48 0.5 2.23e-22 Corneal astigmatism; CRC trans rs4824093 0.610 rs74371371 chr22:50314074 C/T cg09872104 chr7:134855509 C7orf49 -0.87 -8.4 -0.42 1.33e-15 Amyotrophic lateral sclerosis (sporadic); CRC cis rs6831352 0.918 rs2602894 chr4:100045647 A/G cg12011299 chr4:100065546 ADH4 0.5 9.54 0.47 3.24e-19 Alcohol dependence; CRC cis rs9926296 0.572 rs2079671 chr16:89884981 T/C cg27121462 chr16:89883253 FANCA 0.42 6.38 0.33 5.88e-10 Vitiligo; CRC cis rs35306767 0.903 rs11253467 chr10:901244 A/G cg20503657 chr10:835505 NA 0.85 10.82 0.51 1.51e-23 Eosinophil percentage of granulocytes; CRC cis rs6582630 0.547 rs1589388 chr12:38416025 C/T cg26384229 chr12:38710491 ALG10B -0.52 -7.49 -0.38 6.22e-13 Drug-induced liver injury (flucloxacillin); CRC cis rs9303280 0.773 rs12949100 chr17:38057189 G/A cg20243544 chr17:37824526 PNMT 0.38 5.7 0.3 2.73e-8 Self-reported allergy; CRC cis rs6547741 0.935 rs2384626 chr2:27773648 A/G cg27432699 chr2:27873401 GPN1 0.76 14.08 0.61 1.51e-35 Oral cavity cancer; CRC cis rs4722166 0.532 rs6963591 chr7:22757270 G/T cg05472934 chr7:22766657 IL6 -0.64 -10.29 -0.49 1.04e-21 Lung cancer; CRC cis rs1124376 0.688 rs11715447 chr3:20140129 A/C cg05072819 chr3:20081367 KAT2B 0.85 8.93 0.44 3.01e-17 Bipolar disorder and schizophrenia; CRC cis rs798554 0.836 rs13243214 chr7:2817455 G/T cg13628971 chr7:2884303 GNA12 0.53 7.03 0.36 1.18e-11 Height; CRC cis rs6547741 0.935 rs4666004 chr2:27855052 T/A cg27432699 chr2:27873401 GPN1 0.75 13.43 0.6 4.36e-33 Oral cavity cancer; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg04682192 chr12:110561945 IFT81 0.44 6.26 0.33 1.17e-9 Response to antipsychotic treatment; CRC cis rs4253772 0.591 rs6007726 chr22:46650858 A/C cg24881330 chr22:46731750 TRMU 0.56 6.6 0.34 1.61e-10 LDL cholesterol;Cholesterol, total; CRC cis rs477895 1.000 rs34292685 chr11:64049021 C/T cg18225595 chr11:63971243 STIP1 0.6 6.75 0.35 6.81e-11 Mean platelet volume; CRC cis rs4285028 0.948 rs7615571 chr3:121665950 A/C cg20356878 chr3:121714668 ILDR1 -0.47 -6.92 -0.36 2.32e-11 Multiple sclerosis; CRC cis rs9486719 1.000 rs3798289 chr6:97023632 T/C cg18709589 chr6:96969512 KIAA0776 -0.52 -5.85 -0.31 1.21e-8 Migraine;Coronary artery disease; CRC cis rs9457247 0.602 rs4710175 chr6:167467800 A/G cg07741184 chr6:167504864 NA 0.44 7.37 0.38 1.43e-12 Crohn's disease; CRC cis rs10512697 0.892 rs62336107 chr5:3539570 T/C cg19473799 chr5:3511975 NA -0.78 -6.03 -0.32 4.37e-9 Immune response to smallpox vaccine (IL-6); CRC cis rs6502050 0.835 rs7219180 chr17:80079968 C/G cg13198984 chr17:80129470 CCDC57 -0.48 -8.58 -0.43 3.8e-16 Life satisfaction; CRC cis rs12541635 0.966 rs12550587 chr8:106978289 C/T cg10147462 chr8:107024639 NA 0.42 6.78 0.35 5.7e-11 Age of smoking initiation; CRC cis rs875971 0.929 rs12673810 chr7:65923853 T/A cg11764359 chr7:65958608 NA 0.62 9.91 0.48 1.96e-20 Aortic root size; CRC cis rs875971 0.862 rs11763189 chr7:65983529 G/A cg18252515 chr7:66147081 NA -0.43 -6.24 -0.33 1.32e-9 Aortic root size; CRC cis rs6960043 1.000 rs12666046 chr7:15050381 A/G cg19272540 chr7:15055459 NA -0.22 -5.83 -0.31 1.33e-8 Type 2 diabetes; CRC cis rs3820068 0.603 rs6429768 chr1:15963531 G/A cg24675056 chr1:15929824 NA 0.51 7.06 0.36 9.73e-12 Systolic blood pressure; CRC cis rs10193935 0.901 rs6544533 chr2:42516372 G/C cg27598129 chr2:42591480 NA -0.55 -6.58 -0.34 1.88e-10 Colonoscopy-negative controls vs population controls; CRC cis rs3106136 0.967 rs4693377 chr4:95157256 G/C cg11021082 chr4:95130006 SMARCAD1 -0.47 -7.19 -0.37 4.37e-12 Capecitabine sensitivity; CRC cis rs4713118 0.587 rs9393899 chr6:28133528 G/C cg12963246 chr6:28129442 ZNF389 0.49 5.7 0.3 2.71e-8 Parkinson's disease; CRC cis rs13118159 0.550 rs4974617 chr4:1373658 T/C cg16405210 chr4:1374714 KIAA1530 -0.94 -15.14 -0.64 1.15e-39 Longevity; CRC cis rs11148252 0.669 rs61958050 chr13:52994427 A/C cg12458913 chr13:53173898 NA 0.49 6.86 0.35 3.45e-11 Lewy body disease; CRC cis rs4731207 0.672 rs10249081 chr7:124468519 T/G cg23710748 chr7:124431027 NA 0.37 6.03 0.32 4.47e-9 Cutaneous malignant melanoma; CRC cis rs861020 1.000 rs861020 chr1:209977111 A/G cg05527609 chr1:210001259 C1orf107 0.97 12.06 0.55 5.31e-28 Orofacial clefts; CRC cis rs2075371 0.501 rs1643051 chr7:134025372 A/G cg02659138 chr7:134003124 SLC35B4 -0.34 -5.76 -0.3 1.9e-8 Mean platelet volume; CRC cis rs4930561 0.714 rs7945995 chr11:67938302 A/G cg04465784 chr11:67976953 SUV420H1 -0.3 -5.97 -0.31 6.07e-9 Breast cancer in childhood cancer survivors;IgG glycosylation; CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg10651300 chr12:53661859 ESPL1 -0.57 -6.95 -0.36 1.96e-11 Diisocyanate-induced asthma; CRC trans rs2303319 0.504 rs12467613 chr2:162603216 G/T cg10272801 chr16:14013773 ERCC4 -0.68 -6.07 -0.32 3.49e-9 Cognitive function; CRC trans rs75804782 0.641 rs72987304 chr2:239345532 C/T cg01134436 chr17:81009848 B3GNTL1 0.76 7.09 0.36 8.43e-12 Morning vs. evening chronotype;Chronotype; CRC cis rs4423214 0.959 rs11233747 chr11:71171642 G/A cg05163923 chr11:71159392 DHCR7 0.66 9.28 0.46 2.32e-18 Vitamin D levels; CRC cis rs1018836 0.608 rs7843149 chr8:91474961 C/T cg16814680 chr8:91681699 NA -0.57 -8.68 -0.43 1.81e-16 Ejection fraction in Tripanosoma cruzi seropositivity; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg13967780 chr18:46476822 SMAD7 0.44 6.42 0.33 4.88e-10 Intelligence (multi-trait analysis); CRC cis rs9811920 0.638 rs7629426 chr3:99652577 C/G cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G -0.45 -6.1 -0.32 3.04e-9 Axial length; CRC cis rs4888262 0.526 rs4888253 chr16:74583146 C/T cg01733217 chr16:74700730 RFWD3 0.74 11.19 0.53 7.41e-25 Testicular germ cell tumor; CRC trans rs1814175 0.646 rs1722010 chr11:49897958 A/G cg15704280 chr7:45808275 SEPT13 -0.94 -16.63 -0.68 1.72e-45 Height; CRC cis rs9487051 0.676 rs6568568 chr6:109597048 C/T cg01475377 chr6:109611718 NA -0.37 -6.58 -0.34 1.85e-10 Reticulocyte fraction of red cells; CRC cis rs6694672 1.000 rs10754219 chr1:197165186 C/T cg13682187 chr1:196946512 CFHR5 0.53 8.13 0.41 8.91e-15 Asthma; CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg23262020 chr14:93651423 C14orf109;MOAP1 0.37 6.0 0.31 5.13e-9 Obesity-related traits; CRC cis rs6831352 0.918 rs29001199 chr4:100053891 A/G cg13256891 chr4:100009986 ADH5 -0.64 -8.59 -0.43 3.43e-16 Alcohol dependence; CRC cis rs10504229 1.000 rs114486414 chr8:58185103 G/A cg05313129 chr8:58192883 C8orf71 -0.47 -6.99 -0.36 1.49e-11 Developmental language disorder (linguistic errors); CRC cis rs3008870 1.000 rs2755248 chr1:67492624 A/G cg08660285 chr1:67390436 MIER1;WDR78 1.03 15.0 0.64 4.23e-39 Lymphocyte percentage of white cells; CRC cis rs853679 0.517 rs1340004 chr6:28103691 C/T cg03623178 chr6:28175578 NA 0.98 12.95 0.58 2.88e-31 Depression; CRC cis rs9322193 0.887 rs9767113 chr6:150039293 T/C cg00933542 chr6:150070202 PCMT1 0.32 6.33 0.33 7.87e-10 Lung cancer; CRC cis rs9527 0.590 rs11191578 chr10:104902337 A/T cg15744005 chr10:104629667 AS3MT -0.31 -6.1 -0.32 3.03e-9 Arsenic metabolism; CRC trans rs4650994 0.935 rs2811290 chr1:178572978 C/T cg05059571 chr16:84539110 KIAA1609 0.47 7.06 0.36 9.71e-12 HDL cholesterol levels;HDL cholesterol; CRC cis rs10782582 0.609 rs6656501 chr1:76266126 A/C cg03433033 chr1:76189801 ACADM -0.4 -5.83 -0.31 1.35e-8 Daytime sleep phenotypes; CRC cis rs853679 0.517 rs9380052 chr6:28064623 A/G cg03623178 chr6:28175578 NA 1.01 13.37 0.59 7.12e-33 Depression; CRC cis rs11650776 1 rs11650776 chr17:37641402 G/A cg07936489 chr17:37558343 FBXL20 -0.84 -12.93 -0.58 3.44e-31 Lung function (FEV1); CRC cis rs3617 0.625 rs2071042 chr3:52864584 A/G cg11645453 chr3:52864694 ITIH4 0.46 9.17 0.45 5.24e-18 Red blood cell count;Autism spectrum disorder or schizophrenia; CRC cis rs270601 0.770 rs4361510 chr5:131599647 C/T cg09877947 chr5:131593287 PDLIM4 0.53 9.92 0.48 1.81e-20 Acylcarnitine levels; CRC cis rs7572644 0.640 rs7593136 chr2:28017792 A/G cg27432699 chr2:27873401 GPN1 0.48 6.32 0.33 8.67e-10 Response to carboplatin and paclitaxel in ovarian cancer (Caspase 3/7 EC50); CRC trans rs11039571 0.588 rs61917001 chr11:48233667 G/C cg03929089 chr4:120376271 NA 0.67 7.16 0.37 5.46e-12 D-dimer levels; CRC cis rs758324 0.891 rs652839 chr5:131281106 G/C cg25547332 chr5:131281432 NA -0.38 -5.82 -0.31 1.38e-8 Alzheimer's disease in APOE e4- carriers; CRC cis rs9467160 1.000 rs12198188 chr6:24442482 A/G cg20631270 chr6:24437470 GPLD1 0.48 6.34 0.33 7.61e-10 Liver enzyme levels; CRC cis rs11112613 0.762 rs73184077 chr12:105949999 G/A cg03607813 chr12:105948248 NA 0.82 10.85 0.51 1.21e-23 Corrected insulin response;Corrected insulin response adjusted for insulin sensitivity index; CRC cis rs7107174 1.000 rs10501426 chr11:78057122 C/T cg02023728 chr11:77925099 USP35 0.51 8.92 0.44 3.39e-17 Testicular germ cell tumor; CRC cis rs7586879 0.789 rs13398155 chr2:25128550 C/T cg04586622 chr2:25135609 ADCY3 -0.57 -9.75 -0.47 6.54e-20 Body mass index; CRC cis rs3106136 0.564 rs60428594 chr4:95103466 C/T cg11021082 chr4:95130006 SMARCAD1 -0.43 -6.16 -0.32 2.15e-9 Capecitabine sensitivity; CRC cis rs7208859 0.614 rs28758251 chr17:29223312 A/T cg13385521 chr17:29058706 SUZ12P 0.69 7.93 0.4 3.48e-14 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs35146811 0.735 rs1061230 chr7:99807265 G/A cg00553149 chr7:99775558 STAG3;GPC2 -0.24 -5.9 -0.31 8.81e-9 Coronary artery disease; CRC cis rs1401999 1.000 rs10937158 chr3:183708439 T/C cg01324343 chr3:183735012 ABCC5 0.8 14.55 0.63 2.16e-37 Anterior chamber depth; CRC cis rs7312933 0.558 rs3747560 chr12:42719890 A/G cg11827402 chr12:42719852 PPHLN1;ZCRB1 -0.63 -9.23 -0.45 3.51e-18 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CRC cis rs17767392 0.874 rs34767050 chr14:71780957 A/G cg13720639 chr14:72061746 SIPA1L1 -0.55 -6.95 -0.36 1.99e-11 Mitral valve prolapse; CRC cis rs8040855 0.627 rs12913859 chr15:85638418 A/G cg10818794 chr15:86012489 AKAP13 -0.43 -5.71 -0.3 2.49e-8 Bulimia nervosa; CRC cis rs7937682 0.961 rs491937 chr11:111494947 A/T cg09085632 chr11:111637200 PPP2R1B -0.99 -19.6 -0.73 3.25e-57 Primary sclerosing cholangitis; CRC cis rs10504229 0.815 rs17805008 chr8:58160185 G/T cg05313129 chr8:58192883 C8orf71 -0.48 -6.25 -0.33 1.25e-9 Developmental language disorder (linguistic errors); CRC trans rs9388451 0.874 rs1159974 chr6:126090277 C/T cg05039488 chr6:79577232 IRAK1BP1 0.57 8.97 0.44 2.22e-17 Brugada syndrome; CRC cis rs929354 0.713 rs6459733 chr7:156930550 G/C cg05182265 chr7:156933206 UBE3C -0.75 -13.65 -0.6 6.23e-34 Body mass index; CRC cis rs7107174 1.000 rs2510046 chr11:77988817 T/C cg02023728 chr11:77925099 USP35 0.51 7.42 0.38 1e-12 Testicular germ cell tumor; CRC cis rs7727544 1.000 rs10076701 chr5:131596419 A/G cg12564285 chr5:131593104 PDLIM4 0.41 8.14 0.41 8.3e-15 Blood metabolite levels; CRC cis rs73206853 0.563 rs57488849 chr12:111181785 C/T cg12870014 chr12:110450643 ANKRD13A 0.78 8.36 0.42 1.78e-15 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC cis rs9488822 0.676 rs1338667 chr6:116323910 T/A cg26893134 chr6:116381904 FRK 0.26 7.61 0.39 2.98e-13 Cholesterol, total;LDL cholesterol; CRC cis rs870825 0.616 rs57316663 chr4:185630011 T/C cg04058563 chr4:185651563 MLF1IP 0.72 9.38 0.46 1.12e-18 Blood protein levels; CRC cis rs35883536 0.626 rs7545966 chr1:101047633 G/A cg06223162 chr1:101003688 GPR88 -0.34 -6.07 -0.32 3.51e-9 Monocyte count; CRC cis rs7208859 0.614 rs73265646 chr17:29244023 C/T cg14008862 chr17:28927542 LRRC37B2 0.56 5.82 0.31 1.42e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs1005277 0.602 rs1831315 chr10:38473353 T/C cg00409905 chr10:38381863 ZNF37A -0.66 -10.72 -0.51 3.46e-23 Extrinsic epigenetic age acceleration; CRC trans rs701145 0.556 rs191651 chr3:153973887 T/G cg22545385 chr10:131989303 NA -0.41 -6.0 -0.31 5.34e-9 Coronary artery disease; CRC cis rs35306767 0.714 rs28512382 chr10:1092195 G/C cg26597838 chr10:835615 NA 0.82 9.46 0.46 6.06e-19 Eosinophil percentage of granulocytes; CRC cis rs832540 0.552 rs252924 chr5:56205643 A/G cg24531977 chr5:56204891 C5orf35 -0.58 -9.01 -0.45 1.67e-17 Coronary artery disease; CRC cis rs9292777 0.901 rs114400949 chr5:40419143 G/C cg09067459 chr5:40385259 NA 0.53 9.25 0.45 3.02e-18 Crohn's disease;Multiple sclerosis; CRC cis rs10504229 0.683 rs2318143 chr8:58114660 C/T cg02290350 chr8:58132656 NA -0.58 -8.24 -0.41 4.09e-15 Developmental language disorder (linguistic errors); CRC cis rs2857891 0.909 rs56372435 chr11:6938658 T/C cg06872519 chr11:6947619 ZNF215 0.58 5.79 0.3 1.68e-8 Response to cytadine analogues (cytosine arabinoside); CRC cis rs62064224 0.589 rs2041306 chr17:30665675 T/C cg18200150 chr17:30822561 MYO1D 0.46 8.8 0.44 8.13e-17 Schizophrenia; CRC cis rs7769051 1.000 rs6910639 chr6:133120553 A/G cg07930552 chr6:133119739 C6orf192 0.72 8.69 0.43 1.71e-16 Type 2 diabetes nephropathy; CRC cis rs7945718 0.621 rs11022463 chr11:12685395 T/C cg25843174 chr11:12811716 TEAD1 0.39 7.17 0.37 4.89e-12 Educational attainment (years of education); CRC cis rs3749237 0.595 rs1464566 chr3:49459376 T/C cg07636037 chr3:49044803 WDR6 0.55 8.1 0.41 1.11e-14 Resting heart rate; CRC trans rs57221529 0.713 rs72703072 chr5:590626 A/G cg25482853 chr8:67687455 SGK3 1.19 14.38 0.62 1e-36 Lung disease severity in cystic fibrosis; CRC cis rs10791323 0.604 rs2851116 chr11:133705759 G/A cg00579200 chr11:133705235 NA -0.4 -5.76 -0.3 1.94e-8 Childhood ear infection; CRC cis rs6582630 0.560 rs11504462 chr12:38440379 G/A cg26384229 chr12:38710491 ALG10B -0.52 -7.51 -0.38 5.69e-13 Drug-induced liver injury (flucloxacillin); CRC trans rs12940923 1.000 rs12949848 chr17:56362067 A/G cg16900910 chr15:72789182 ARIH1 0.54 6.21 0.32 1.61e-9 Circulating myeloperoxidase levels (plasma); CRC cis rs2455601 0.786 rs3763914 chr11:8940703 G/T cg21881798 chr11:8931708 C11orf17;ST5 -0.56 -6.43 -0.33 4.53e-10 Schizophrenia; CRC cis rs17270561 0.609 rs9358872 chr6:25727517 G/A cg17691542 chr6:26056736 HIST1H1C 0.73 9.31 0.46 1.82e-18 Iron status biomarkers; CRC cis rs9649213 0.593 rs7795176 chr7:97978287 A/C cg00277769 chr7:97922759 BAIAP2L1 -0.6 -10.31 -0.49 8.94e-22 Prostate cancer (SNP x SNP interaction); CRC cis rs12142240 0.698 rs72677599 chr1:46834251 G/A cg14993813 chr1:46806288 NSUN4 -0.49 -6.26 -0.33 1.21e-9 Menopause (age at onset); CRC cis rs921968 0.643 rs563268 chr2:219372912 T/G cg02176678 chr2:219576539 TTLL4 0.5 8.1 0.41 1.06e-14 Mean corpuscular hemoglobin concentration; CRC cis rs4243830 0.850 rs6679649 chr1:6606608 C/T cg22792644 chr1:6614718 TAS1R1;NOL9 0.84 11.7 0.54 1.11e-26 Body mass index; CRC cis rs2050392 0.792 rs684395 chr10:30719112 C/G cg18806716 chr10:30721971 MAP3K8 -0.49 -7.36 -0.38 1.52e-12 Inflammatory bowel disease; CRC cis rs4819052 0.851 rs12626188 chr21:46669258 A/G cg19498844 chr21:46707878 POFUT2;LOC642852 0.73 10.42 0.5 3.76e-22 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs2404618 0.587 rs6994849 chr8:1492839 G/T cg02903104 chr8:1507517 DLGAP2 -0.49 -8.26 -0.41 3.53e-15 Lung cancer; CRC cis rs8072100 0.713 rs8074451 chr17:45477573 C/T cg08085267 chr17:45401833 C17orf57 -0.58 -8.79 -0.44 8.23e-17 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs4332037 0.539 rs62444881 chr7:2052318 C/T cg23422044 chr7:1970798 MAD1L1 -0.57 -6.82 -0.35 4.26e-11 Bipolar disorder; CRC cis rs11030122 0.569 rs11030781 chr11:4083258 T/C cg18678763 chr11:4115507 RRM1 -0.49 -7.91 -0.4 3.82e-14 Mean platelet volume;Platelet distribution width; CRC cis rs3751196 0.808 rs7314150 chr12:104213731 A/G cg02344784 chr12:104178138 NT5DC3 0.69 8.05 0.41 1.53e-14 Sense of smell; CRC cis rs7811142 0.830 rs75636500 chr7:99947657 C/G cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.94 11.77 0.54 6.41e-27 Platelet count; CRC cis rs13108904 0.901 rs4516656 chr4:1279860 A/G cg19318889 chr4:1322082 MAEA 0.4 5.68 0.3 2.94e-8 Obesity-related traits; CRC cis rs394563 0.534 rs388335 chr6:149791986 T/C cg07828024 chr6:149772892 ZC3H12D -0.45 -7.15 -0.37 5.53e-12 Dupuytren's disease; CRC cis rs7246657 0.943 rs4803460 chr19:37885228 T/C cg23950597 chr19:37808831 NA -0.5 -6.12 -0.32 2.68e-9 Coronary artery calcification; CRC cis rs138055607 1 rs138055607 chr10:75450901 C/G cg07699608 chr10:75541558 CHCHD1 0.64 6.2 0.32 1.68e-9 Initial pursuit acceleration; CRC trans rs1814175 0.715 rs7479622 chr11:49673340 T/G cg03929089 chr4:120376271 NA -0.94 -17.32 -0.69 3.16e-48 Height; CRC cis rs4589502 0.512 rs7183242 chr15:67096658 A/G cg12317470 chr15:67143691 NA 0.68 9.95 0.48 1.4e-20 Lung cancer (smoking interaction); CRC cis rs977987 0.778 rs35214308 chr16:75476088 C/T cg03315344 chr16:75512273 CHST6 0.55 9.35 0.46 1.39e-18 Dupuytren's disease; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg11062677 chr19:13976917 NA 0.46 6.48 0.34 3.36e-10 Response to antipsychotic treatment; CRC cis rs116095464 0.558 rs1971229 chr5:268187 A/G cg22857025 chr5:266934 NA -1.25 -16.93 -0.68 1.14e-46 Breast cancer; CRC cis rs6456156 0.526 rs1854853 chr6:167533062 A/G cg07513332 chr6:167530253 CCR6 -0.4 -7.52 -0.38 5.11e-13 Primary biliary cholangitis; CRC trans rs1908814 0.510 rs57655799 chr8:11782417 A/C cg06636001 chr8:8085503 FLJ10661 0.48 7.27 0.37 2.61e-12 Neuroticism; CRC cis rs9560113 0.573 rs9560132 chr13:112237456 C/T cg10483660 chr13:112241077 NA 0.62 11.82 0.55 4.13e-27 Menarche (age at onset); CRC cis rs1568889 1.000 rs35343234 chr11:28034379 C/T cg06544937 chr11:28130018 METT5D1;KIF18A 0.79 10.88 0.51 9.46e-24 Bipolar disorder; CRC cis rs79387448 0.701 rs3752659 chr2:103001598 A/G cg00507830 chr2:103233733 NA 0.55 5.87 0.31 1.08e-8 Gut microbiota (bacterial taxa); CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg03443922 chr7:107384711 CBLL1 0.49 6.19 0.32 1.74e-9 Thyroid stimulating hormone; CRC cis rs7412746 0.658 rs11581757 chr1:150892244 A/G cg17724175 chr1:150552817 MCL1 0.45 6.83 0.35 4.24e-11 Melanoma; CRC trans rs75828804 0.826 rs116168751 chr16:77567902 G/A cg19423196 chr10:82049429 MAT1A 0.51 6.08 0.32 3.39e-9 Intraocular pressure; CRC cis rs835154 1.000 rs835154 chr5:14876569 A/G cg18064842 chr5:14874549 NA 0.49 7.22 0.37 3.69e-12 Blood metabolite levels; CRC cis rs12216125 0.801 rs56107510 chr6:25987436 C/A cg17691542 chr6:26056736 HIST1H1C 0.61 8.57 0.43 4e-16 Iron status biomarkers; CRC cis rs12762955 0.687 rs4880470 chr10:1077480 G/A cg04006718 chr10:1068667 C10orf110;IDI2 0.4 5.64 0.3 3.68e-8 Response to angiotensin II receptor blocker therapy; CRC cis rs10504229 0.683 rs16921937 chr8:58145010 A/G cg05313129 chr8:58192883 C8orf71 -0.43 -5.88 -0.31 1.02e-8 Developmental language disorder (linguistic errors); CRC cis rs394563 0.619 rs4895787 chr6:149646500 G/A cg17885791 chr6:149771845 ZC3H12D 0.32 5.78 0.3 1.76e-8 Dupuytren's disease; CRC cis rs28374715 0.662 rs13329579 chr15:41467435 C/T cg18705301 chr15:41695430 NDUFAF1 -0.91 -13.71 -0.6 3.74e-34 Ulcerative colitis; CRC trans rs10842750 1.000 rs10842750 chr12:26690565 G/T cg12843489 chr17:35061545 NA 0.34 6.15 0.32 2.31e-9 Kashin-Beck disease; CRC cis rs2635047 0.783 rs9952447 chr18:44784700 C/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.37 5.73 0.3 2.3e-8 Educational attainment; CRC cis rs2180341 0.920 rs1073931 chr6:127681762 A/T cg24812749 chr6:127587940 RNF146 0.91 13.0 0.58 1.85e-31 Breast cancer; CRC cis rs11031096 0.754 rs10742242 chr11:4156851 T/C cg18678763 chr11:4115507 RRM1 -0.44 -7.62 -0.39 2.78e-13 Mean corpuscular volume;Mean corpuscular hemoglobin; CRC cis rs736408 0.812 rs2240920 chr3:52831009 A/G cg15147215 chr3:52552868 STAB1 0.47 6.92 0.36 2.37e-11 Bipolar disorder; CRC cis rs7112925 0.966 rs11602157 chr11:66827319 G/A cg24851651 chr11:66362959 CCS -0.39 -6.7 -0.35 8.9e-11 Height; CRC cis rs28386778 0.966 rs2854206 chr17:61947203 G/A cg11494091 chr17:61959527 GH2 0.6 10.24 0.49 1.57e-21 Prudent dietary pattern; CRC cis rs35110281 0.744 rs230644 chr21:44917183 C/T cg01579765 chr21:45077557 HSF2BP 0.35 6.35 0.33 6.98e-10 Mean corpuscular volume; CRC trans rs8035957 1.000 rs4924273 chr15:38846738 C/G cg07936430 chr16:30538244 ZNF768 -0.53 -6.47 -0.34 3.56e-10 Type 1 diabetes; CRC cis rs8062405 0.723 rs4788079 chr16:28559363 C/A cg16576597 chr16:28551801 NUPR1 0.56 8.26 0.41 3.67e-15 Cognitive ability (multi-trait analysis);Cognitive ability; CRC cis rs780096 0.526 rs3845687 chr2:27689899 T/C cg22903471 chr2:27725779 GCKR -0.35 -5.61 -0.3 4.21e-8 Total body bone mineral density; CRC cis rs9846480 0.516 rs6439805 chr3:138056658 C/T cg25476813 chr3:138050155 TXNDC6 -0.38 -5.73 -0.3 2.24e-8 Whole-brain volume (Alzheimer's disease interaction); CRC cis rs4713118 0.662 rs149970 chr6:27980220 C/T cg12172441 chr6:28176163 NA 0.58 7.61 0.39 2.96e-13 Parkinson's disease; CRC cis rs9393692 0.620 rs9393691 chr6:26272829 T/C cg00631329 chr6:26305371 NA -0.53 -9.1 -0.45 8.69e-18 Educational attainment; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg07643503 chr18:32820679 ZNF397 0.44 6.19 0.32 1.8e-9 Response to antipsychotic treatment; CRC cis rs6543140 0.865 rs6760275 chr2:103079607 C/T cg03938978 chr2:103052716 IL18RAP 0.41 6.53 0.34 2.51e-10 Blood protein levels; CRC trans rs2727020 0.521 rs10839285 chr11:49496852 T/G cg11707556 chr5:10655725 ANKRD33B 0.46 7.58 0.39 3.67e-13 Coronary artery disease; CRC trans rs61931739 0.517 rs11052980 chr12:34036036 T/C cg26384229 chr12:38710491 ALG10B 0.47 6.36 0.33 6.58e-10 Morning vs. evening chronotype; CRC cis rs796364 0.951 rs36086821 chr2:201067436 G/A cg25936922 chr2:200820526 C2orf60;C2orf47 0.54 6.03 0.32 4.42e-9 Schizophrenia; CRC cis rs60871478 0.636 rs10245785 chr7:894422 T/C cg05535760 chr7:792225 HEATR2 -0.91 -10.29 -0.49 1e-21 Cerebrospinal P-tau181p levels; CRC cis rs9291683 0.530 rs4235346 chr4:9945296 C/T cg00071950 chr4:10020882 SLC2A9 -0.63 -11.48 -0.53 7.23e-26 Bone mineral density; CRC cis rs60871478 0.679 rs6962050 chr7:817201 A/G cg13798912 chr7:905769 UNC84A 0.54 6.17 0.32 1.97e-9 Cerebrospinal P-tau181p levels; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg11814422 chr18:47018265 SNORD58A;RPL17;SNORD58B 0.47 7.04 0.36 1.16e-11 Response to antipsychotic treatment; CRC cis rs9399137 0.507 rs61738647 chr6:135282735 T/C cg22676075 chr6:135203613 NA 0.62 9.17 0.45 5.29e-18 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; CRC cis rs8072100 0.676 rs7221345 chr17:45405144 G/A cg08085267 chr17:45401833 C17orf57 -0.77 -13.86 -0.61 1.02e-34 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs2421770 0.530 rs11033084 chr11:35367408 T/G cg13971030 chr11:35366721 SLC1A2 -0.38 -6.55 -0.34 2.18e-10 Staphylococcus aureus nasal carriage (persistent); CRC cis rs611744 0.647 rs579162 chr8:109254842 A/G cg18478394 chr8:109455254 TTC35 0.39 6.03 0.32 4.51e-9 Dupuytren's disease; CRC cis rs875971 0.965 rs9969301 chr7:65781655 G/A cg12463550 chr7:65579703 CRCP -0.48 -7.02 -0.36 1.25e-11 Aortic root size; CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg11928684 chr11:47291227 MADD 0.38 6.0 0.31 5.08e-9 Obesity-related traits; CRC cis rs4665809 1.000 rs750450 chr2:26324631 A/G cg04944784 chr2:26401820 FAM59B -0.58 -7.21 -0.37 3.88e-12 Gut microbiome composition (summer); CRC cis rs9467711 0.606 rs12174623 chr6:26373086 C/T cg14345882 chr6:26364793 BTN3A2 0.65 5.73 0.3 2.32e-8 Autism spectrum disorder or schizophrenia; CRC cis rs12024301 0.557 rs59872949 chr1:183613649 T/C cg11505048 chr1:183622726 RGL1;APOBEC4 0.81 7.14 0.37 5.93e-12 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs870825 0.616 rs4416519 chr4:185639502 T/C cg04058563 chr4:185651563 MLF1IP 0.73 9.41 0.46 9.01e-19 Blood protein levels; CRC cis rs9486715 0.867 rs9486444 chr6:96963619 A/G cg18709589 chr6:96969512 KIAA0776 0.49 7.2 0.37 4.01e-12 Headache; CRC cis rs4481887 0.927 rs10749651 chr1:248472930 T/C cg00666640 chr1:248458726 OR2T12 0.45 7.8 0.4 8.31e-14 Common traits (Other); CRC cis rs6502050 0.835 rs8077926 chr17:80117315 C/A cg13198984 chr17:80129470 CCDC57 0.46 8.18 0.41 6.3e-15 Life satisfaction; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg04621255 chr9:131581398 ENDOG 0.47 6.02 0.31 4.65e-9 Thyroid stimulating hormone; CRC cis rs8180040 0.966 rs11707895 chr3:47574937 G/A cg02527881 chr3:46936655 PTH1R 0.38 6.77 0.35 6.09e-11 Colorectal cancer; CRC cis rs60871478 0.947 rs62432866 chr7:809281 T/G cg13844804 chr7:814759 HEATR2 0.66 8.67 0.43 1.99e-16 Cerebrospinal P-tau181p levels; CRC cis rs2836974 0.897 rs35386515 chr21:40532047 C/T cg11890956 chr21:40555474 PSMG1 1.08 19.11 0.73 2.82e-55 Cognitive function; CRC cis rs9733 0.621 rs6669122 chr1:150591732 A/G cg18016565 chr1:150552671 MCL1 -0.47 -6.96 -0.36 1.89e-11 Tonsillectomy; CRC cis rs7937682 0.889 rs1784785 chr11:111483306 A/G cg19812747 chr11:111475976 SIK2 -0.59 -10.14 -0.49 3.31e-21 Primary sclerosing cholangitis; CRC cis rs13392177 0.684 rs11695527 chr2:219068103 A/G cg04880052 chr2:219191631 PNKD 0.39 5.96 0.31 6.38e-9 Pyoderma gangrenosum in inflammatory bowel disease; CRC cis rs10461617 0.592 rs6450403 chr5:56062737 A/C cg03609598 chr5:56110824 MAP3K1 -0.6 -7.51 -0.38 5.59e-13 Type 2 diabetes; CRC cis rs28386778 0.897 rs6504187 chr17:61917099 G/A cg25654072 chr17:61904446 PSMC5;FTSJ3 0.74 11.42 0.53 1.12e-25 Prudent dietary pattern; CRC cis rs7917772 0.536 rs17783771 chr10:104410736 C/T cg22532475 chr10:104410764 TRIM8 -0.42 -7.03 -0.36 1.23e-11 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC cis rs1448094 0.817 rs10863122 chr12:86346047 T/C cg18827107 chr12:86230957 RASSF9 -0.43 -6.86 -0.35 3.44e-11 Major depressive disorder; CRC cis rs7804356 1.000 rs3801807 chr7:26897439 T/C cg03456212 chr7:26904342 SKAP2 -0.5 -5.69 -0.3 2.77e-8 Type 1 diabetes; CRC trans rs1814175 0.817 rs1851860 chr11:49861310 A/C cg11707556 chr5:10655725 ANKRD33B -0.42 -8.07 -0.41 1.34e-14 Height; CRC cis rs311392 0.902 rs423150 chr8:55092804 C/T cg06042504 chr8:55087323 NA -0.44 -6.82 -0.35 4.41e-11 Pelvic organ prolapse (moderate/severe); CRC cis rs9549367 0.713 rs11620600 chr13:113829090 G/A cg00898013 chr13:113819073 PROZ -0.57 -8.12 -0.41 9.17e-15 Platelet distribution width; CRC cis rs10256972 0.616 rs7806746 chr7:1075573 A/C cg04025307 chr7:1156635 C7orf50 0.38 6.0 0.31 5.16e-9 Longevity;Endometriosis; CRC cis rs6908034 0.660 rs111231540 chr6:19802226 A/C cg02682789 chr6:19804855 NA 0.81 6.89 0.35 2.9100000000000002e-11 Endometriosis;Deep ovarian and/or rectovaginal disease with dense adhesions; CRC cis rs7537052 0.564 rs6669395 chr1:36653717 A/G cg24686825 chr1:36642396 MAP7D1 -0.59 -8.44 -0.42 1.05e-15 Schizophrenia; CRC cis rs13256369 1.000 rs873063 chr8:8572447 A/G cg00074818 chr8:8560427 CLDN23 0.42 7.67 0.39 1.96e-13 Obesity-related traits; CRC cis rs4665809 0.652 rs6728090 chr2:26524726 C/T cg08067268 chr2:26466485 HADHB;HADHA -0.51 -6.89 -0.35 2.92e-11 Gut microbiome composition (summer); CRC cis rs9894429 0.646 rs7405870 chr17:79617284 G/A cg09655341 chr17:79618100 PDE6G -0.37 -6.26 -0.33 1.21e-9 Eye color traits; CRC trans rs11989744 0.500 rs7826517 chr8:23568841 G/A cg03492747 chr16:86543808 FOXF1 -0.58 -10.44 -0.5 3.12e-22 Waist-hip ratio; CRC cis rs6662572 0.737 rs6700322 chr1:46409176 G/T cg08644498 chr1:46502608 NA -0.44 -6.98 -0.36 1.61e-11 Blood protein levels; CRC cis rs12594515 1.000 rs8026221 chr15:45987910 G/T cg19682013 chr15:45996608 NA 0.32 6.7 0.35 9.09e-11 Waist circumference;Weight; CRC cis rs8060686 0.641 rs79577483 chr16:68036939 A/G cg26727032 chr16:67993705 SLC12A4 -0.53 -5.93 -0.31 7.68e-9 HDL cholesterol;Metabolic syndrome; CRC cis rs736408 0.609 rs13082960 chr3:52785168 A/C cg05573699 chr3:52720067 GNL3;PBRM1 -0.46 -6.49 -0.34 3.08e-10 Bipolar disorder; CRC cis rs17092148 0.597 rs57495888 chr20:33092724 T/C cg08999081 chr20:33150536 PIGU -0.47 -5.74 -0.3 2.2e-8 Neuroticism; CRC cis rs10078 0.559 rs2037077 chr5:447226 A/G cg14122633 chr5:456516 EXOC3 -0.48 -5.66 -0.3 3.27e-8 Fat distribution (HIV); CRC cis rs6681460 0.800 rs481681 chr1:67194378 G/A cg02459107 chr1:67143332 SGIP1 -0.37 -6.34 -0.33 7.5e-10 Presence of antiphospholipid antibodies; CRC cis rs13191362 0.507 rs2846535 chr6:163034019 T/C cg21926612 chr6:163149169 PACRG;PARK2 -0.61 -9.64 -0.47 1.56e-19 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs305851 0.692 rs9380893 chr6:39745436 C/G cg02386599 chr6:39769542 DAAM2 -0.37 -5.78 -0.3 1.75e-8 Lobe attachment (rater-scored or self-reported); CRC cis rs9467711 0.606 rs9393718 chr6:26407482 G/A cg12315302 chr6:26189340 HIST1H4D 0.78 6.07 0.32 3.43e-9 Autism spectrum disorder or schizophrenia; CRC cis rs1971762 0.583 rs3844370 chr12:54086137 G/C cg06632207 chr12:54070931 ATP5G2 0.43 7.24 0.37 3.13e-12 Height; CRC cis rs477895 0.713 rs12575642 chr11:63979643 G/T cg18225595 chr11:63971243 STIP1 0.61 8.13 0.41 8.6e-15 Mean platelet volume; CRC cis rs56116382 0.604 rs9858428 chr3:49877585 G/T cg00383909 chr3:49044727 WDR6 1.23 10.88 0.51 9.55e-24 Intelligence (multi-trait analysis);High light scatter reticulocyte count; CRC cis rs2457480 0.850 rs11238902 chr10:44681091 C/T cg09554077 chr10:44749378 NA 0.7 7.85 0.4 5.95e-14 Coronary artery disease; CRC cis rs9287719 0.967 rs9287720 chr2:10752664 C/T cg00105475 chr2:10696890 NA 0.45 7.17 0.37 4.85e-12 Prostate cancer; CRC cis rs28680850 1.000 rs28680850 chr8:1373720 G/A cg06016156 chr8:1399969 NA -0.48 -5.78 -0.3 1.75e-8 Triglycerides; CRC trans rs7819412 0.775 rs34094119 chr8:10935898 A/G cg16141378 chr3:129829833 LOC729375 0.45 6.36 0.33 6.94e-10 Triglycerides; CRC cis rs13108904 0.934 rs13125338 chr4:1278435 A/C cg00684032 chr4:1343700 KIAA1530 0.49 7.25 0.37 3.04e-12 Obesity-related traits; CRC cis rs8072100 0.875 rs9635762 chr17:45648446 A/C cg25173405 chr17:45401733 C17orf57 0.43 6.76 0.35 6.22e-11 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs6951245 1.000 rs11763793 chr7:1094342 A/G cg21664854 chr7:1097933 C7orf50;GPR146 0.77 8.77 0.44 9.87e-17 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC trans rs35365539 1 rs35365539 chr3:49794347 A/AC cg21582582 chr3:182698605 DCUN1D1 -0.56 -8.35 -0.42 1.88e-15 Blood protein levels; CRC cis rs7463659 0.904 rs7826572 chr8:135433805 G/T cg17885191 chr8:135476712 NA -0.4 -5.89 -0.31 9.64e-9 Colonoscopy-negative controls vs population controls; CRC cis rs651907 0.535 rs34648996 chr3:101511202 A/G cg11279151 chr3:101281821 RG9MTD1 -0.53 -7.04 -0.36 1.14e-11 Colorectal cancer; CRC cis rs9322193 0.962 rs10452626 chr6:150088617 T/C cg07701084 chr6:150067640 NUP43 0.46 6.49 0.34 3.1e-10 Lung cancer; CRC cis rs8072100 0.570 rs9905073 chr17:45468296 G/A cg08085267 chr17:45401833 C17orf57 -0.58 -8.79 -0.44 8.45e-17 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC trans rs12310399 0.772 rs7971041 chr12:95526019 C/T cg09150239 chr1:204347429 NA 0.43 6.22 0.32 1.47e-9 Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel + carboplatin); CRC cis rs56235845 0.694 rs36102285 chr5:176774018 C/T cg16006841 chr5:176797999 RGS14 0.54 8.72 0.43 1.38e-16 Hemoglobin concentration;Hematocrit; CRC cis rs6121246 0.697 rs6060912 chr20:30325755 C/A cg13852791 chr20:30311386 BCL2L1 0.67 10.95 0.52 5.48e-24 Mean corpuscular hemoglobin; CRC cis rs9309711 0.666 rs6723101 chr2:3484443 T/C cg10845886 chr2:3471009 TTC15 -0.4 -6.33 -0.33 7.99e-10 Neurofibrillary tangles; CRC cis rs3785574 0.962 rs62077509 chr17:61848973 A/G cg23090583 chr17:61904693 PSMC5;FTSJ3 0.65 9.52 0.46 3.78e-19 Height; CRC cis rs9462027 0.628 rs1543558 chr6:34784371 T/C cg07306190 chr6:34760872 UHRF1BP1 -0.34 -6.08 -0.32 3.4e-9 Systemic lupus erythematosus; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg03202064 chr16:73091917 ZFHX3 0.48 6.68 0.35 1.02e-10 Anxiety disorder; CRC cis rs1008375 1.000 rs55939327 chr4:17642937 T/A cg04450456 chr4:17643702 FAM184B 0.41 6.62 0.34 1.46e-10 Parasitemia in Tripanosoma cruzi seropositivity; CRC trans rs10875746 0.903 rs17122666 chr12:48502574 C/T cg16281234 chr15:35388805 NA -0.5 -6.25 -0.33 1.3e-9 Longevity (90 years and older); CRC cis rs138880 0.505 rs56248708 chr22:50306969 G/A cg22709217 chr22:50311962 ALG12;CRELD2 -1.03 -10.35 -0.5 6.51e-22 Schizophrenia; CRC cis rs4713118 0.513 rs149962 chr6:28015918 G/A cg12172441 chr6:28176163 NA 0.49 6.73 0.35 7.38e-11 Parkinson's disease; CRC cis rs875971 0.540 rs1723268 chr7:65473080 A/C cg11764359 chr7:65958608 NA 0.52 7.83 0.4 6.97e-14 Aortic root size; CRC cis rs67311347 1.000 rs73078158 chr3:40472567 G/C cg24209194 chr3:40518798 ZNF619 0.42 6.03 0.32 4.34e-9 Renal cell carcinoma; CRC cis rs7618915 0.571 rs11130307 chr3:52607682 G/A cg10802521 chr3:52805072 NEK4 -0.59 -9.05 -0.45 1.33e-17 Bipolar disorder; CRC cis rs6062302 0.522 rs2872810 chr20:62241931 C/T cg16989086 chr20:62203971 PRIC285 -0.5 -6.61 -0.34 1.55e-10 Glioblastoma; CRC cis rs9303401 0.614 rs3803753 chr17:56540110 G/A cg02118635 chr17:56770003 RAD51C;TEX14 0.77 9.6 0.47 2.14e-19 Cognitive test performance; CRC cis rs9372498 0.572 rs62422190 chr6:118909235 A/G cg24463073 chr6:118973353 C6orf204 0.54 7.13 0.37 6.33e-12 Diastolic blood pressure; CRC cis rs7726839 0.540 rs74553517 chr5:665671 C/T cg14541582 chr5:601475 NA -0.34 -6.46 -0.34 3.71e-10 Obesity-related traits; CRC cis rs35146811 0.586 rs10267231 chr7:99595480 T/C cg03265037 chr7:99691720 MIR25;MCM7;MIR106B;MIR93 0.44 5.92 0.31 8.17e-9 Coronary artery disease; CRC cis rs9303401 1.000 rs7218362 chr17:56888299 A/G cg02118635 chr17:56770003 RAD51C;TEX14 0.55 8.28 0.42 3.21e-15 Cognitive test performance; CRC cis rs17125944 0.686 rs7144029 chr14:53333616 G/T cg00686598 chr14:53173677 PSMC6 -0.6 -5.76 -0.3 1.89e-8 Alzheimer's disease (late onset); CRC trans rs1728785 0.818 rs1170430 chr16:68604954 T/C cg04657470 chr2:198365150 HSPE1;HSPD1 0.59 7.14 0.37 6.11e-12 Ulcerative colitis; CRC cis rs7726839 0.540 rs3749615 chr5:601485 C/T cg14541582 chr5:601475 NA -0.36 -7.34 -0.38 1.66e-12 Obesity-related traits; CRC cis rs733592 0.507 rs3825403 chr12:48457159 G/A cg21466736 chr12:48725269 NA 0.5 7.93 0.4 3.47e-14 Plateletcrit; CRC trans rs7937682 0.889 rs3017767 chr11:111508098 A/G cg18187862 chr3:45730750 SACM1L 0.48 6.88 0.35 3.04e-11 Primary sclerosing cholangitis; CRC cis rs9303401 0.614 rs2007993 chr17:56590643 T/C cg02118635 chr17:56770003 RAD51C;TEX14 0.79 9.72 0.47 8.75e-20 Cognitive test performance; CRC cis rs4975709 0.589 rs1466606 chr5:1865055 C/T cg12288994 chr5:1860383 NA 0.37 6.52 0.34 2.63e-10 Cardiovascular disease risk factors; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg08740862 chr11:62314417 AHNAK 0.38 6.38 0.33 5.94e-10 Liver disease severity in Alagille syndrome; CRC cis rs9894429 1.000 rs9747349 chr17:79584297 C/T cg21028142 chr17:79581711 NPLOC4 0.39 8.62 0.43 2.89e-16 Eye color traits; CRC cis rs853679 0.517 rs9357061 chr6:28051772 A/G cg06470822 chr6:28175283 NA 0.98 13.22 0.59 2.69e-32 Depression; CRC cis rs66887589 0.774 rs9307477 chr4:120421809 G/A cg09307838 chr4:120376055 NA 0.55 8.5 0.42 6.63e-16 Diastolic blood pressure; CRC cis rs4665809 0.590 rs6730317 chr2:26419482 C/T cg25036284 chr2:26402008 FAM59B -0.66 -8.52 -0.43 5.82e-16 Gut microbiome composition (summer); CRC cis rs533581 0.866 rs871756 chr16:88969076 G/C cg05579598 chr16:88989069 CBFA2T3 0.34 6.17 0.32 1.99e-9 Social autistic-like traits; CRC cis rs600626 0.636 rs11236514 chr11:75451343 A/C cg24262691 chr11:75473276 NA -0.54 -6.99 -0.36 1.51e-11 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CRC cis rs2242116 0.833 rs6442038 chr3:46960742 A/G cg27129171 chr3:47204927 SETD2 0.63 8.99 0.44 1.96e-17 Birth weight; CRC cis rs8180040 0.587 rs62246398 chr3:47066203 A/C cg10298567 chr3:47292165 KIF9 0.38 5.96 0.31 6.55e-9 Colorectal cancer; CRC cis rs10416265 0.502 rs7245411 chr19:33543029 A/T cg17764715 chr19:33622953 WDR88 0.42 6.14 0.32 2.35e-9 Bone properties (heel); CRC cis rs5750830 0.649 rs5750815 chr22:39798449 T/C cg05872129 chr22:39784769 NA -0.59 -10.68 -0.51 4.67e-23 Intelligence (multi-trait analysis); CRC cis rs7951870 0.617 rs12361673 chr11:46723937 G/A cg19486271 chr11:47235900 DDB2 -0.49 -7.68 -0.39 1.89e-13 Schizophrenia; CRC trans rs7395662 0.591 rs11039776 chr11:48516706 G/A cg03929089 chr4:120376271 NA -0.45 -6.39 -0.33 5.79e-10 HDL cholesterol; CRC cis rs28386778 1.000 rs2665849 chr17:61953670 T/C cg11494091 chr17:61959527 GH2 0.62 10.5 0.5 1.97e-22 Prudent dietary pattern; CRC cis rs12479064 0.724 rs28369945 chr2:100080928 C/G cg14399236 chr2:99771627 LIPT1;TSGA10 -0.61 -7.29 -0.37 2.33e-12 Chronic sinus infection; CRC cis rs9914988 0.943 rs9908881 chr17:27100924 T/A cg07195577 chr17:27052828 TLCD1 0.42 6.02 0.32 4.64e-9 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs875971 0.862 rs6460293 chr7:65810192 C/A cg11764359 chr7:65958608 NA -0.59 -8.76 -0.43 1.05e-16 Aortic root size; CRC cis rs9462846 0.887 rs6907869 chr6:42850919 G/T cg21280719 chr6:42927975 GNMT -0.31 -6.11 -0.32 2.75e-9 Blood protein levels; CRC trans rs1120787 0.793 rs478765 chr18:55013866 C/T cg19077231 chr7:100484514 SRRT -0.54 -6.0 -0.31 5.09e-9 HIV-1 control; CRC cis rs3008870 1.000 rs2985794 chr1:67425311 T/G cg08660285 chr1:67390436 MIER1;WDR78 1.02 15.1 0.64 1.6e-39 Lymphocyte percentage of white cells; CRC cis rs7613875 0.620 rs7430334 chr3:50078221 T/C cg24308560 chr3:49941425 MST1R 0.43 6.82 0.35 4.29e-11 Body mass index; CRC cis rs375066 0.935 rs396874 chr19:44397225 G/C cg12072164 chr19:44306565 LYPD5 0.36 5.61 0.3 4.18e-8 Breast cancer; CRC cis rs78456975 1.000 rs11884854 chr2:1566154 A/G cg12573674 chr2:1569213 NA -0.72 -7.74 -0.39 1.27e-13 Placebo response in major depressive disorder (% change in symptom score); CRC cis rs10493773 0.566 rs11161659 chr1:86183967 T/C cg17807903 chr1:86174739 ZNHIT6 -0.64 -17.36 -0.69 2.23e-48 Urate levels in overweight individuals; CRC cis rs60843830 1.000 rs57542652 chr2:228088 G/A cg25945732 chr2:264204 ACP1;SH3YL1 0.71 11.36 0.53 1.94e-25 Spherical equivalent (joint analysis main effects and education interaction); CRC cis rs6952808 0.792 rs2056481 chr7:1955435 A/G cg00106254 chr7:1943704 MAD1L1 -0.52 -7.73 -0.39 1.32e-13 Bipolar disorder and schizophrenia; CRC cis rs6662572 0.737 rs4660330 chr1:46458298 A/G cg08644498 chr1:46502608 NA -0.46 -7.38 -0.38 1.3e-12 Blood protein levels; CRC cis rs13272623 0.502 rs268628 chr8:71560505 T/C cg23757474 chr8:71581111 LACTB2;XKR9 -0.46 -6.58 -0.34 1.83e-10 IgG glycosylation; CRC cis rs868943 0.743 rs11153591 chr6:116328533 A/T cg26893134 chr6:116381904 FRK 0.28 6.76 0.35 6.29e-11 Total cholesterol levels; CRC cis rs6835098 1.000 rs9990666 chr4:174083150 G/T cg08422745 chr4:174089978 GALNT7 -0.94 -15.69 -0.65 8.5e-42 Dementia and core Alzheimer's disease neuropathologic changes; CRC cis rs1008375 0.902 rs12503164 chr4:17656107 C/T cg16339924 chr4:17578868 LAP3 0.6 8.15 0.41 7.6e-15 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs7618915 0.798 rs353547 chr3:52268866 A/G cg08222913 chr3:52553049 STAB1 0.34 5.95 0.31 6.98e-9 Bipolar disorder; CRC cis rs1799949 0.773 rs2137990 chr17:41317896 T/A cg25072359 chr17:41440525 NA -0.51 -8.13 -0.41 8.77e-15 Menopause (age at onset); CRC cis rs6460942 0.818 rs73299043 chr7:12251595 C/G cg06484146 chr7:12443880 VWDE -0.59 -6.05 -0.32 3.93e-9 Coronary artery disease; CRC cis rs10540 0.730 rs61876338 chr11:493730 A/G cg03934478 chr11:495069 RNH1 0.69 7.73 0.39 1.28e-13 Body mass index; CRC cis rs1322512 0.883 rs2758814 chr6:152966367 C/T cg03415253 chr6:152958462 SYNE1 -0.44 -6.77 -0.35 5.99e-11 Tonometry; CRC cis rs6788895 1.000 rs6769917 chr3:150509604 A/T cg09723797 chr3:150481914 SIAH2 -0.81 -6.64 -0.34 1.27e-10 Breast cancer; CRC cis rs2688482 0.557 rs2550236 chr3:195522321 A/G cg11598736 chr3:195384522 SDHAP2 0.61 6.23 0.33 1.39e-9 Lung disease severity in cystic fibrosis; CRC cis rs6460942 1.000 rs6460938 chr7:12406808 T/G cg20607287 chr7:12443886 VWDE -0.63 -6.58 -0.34 1.85e-10 Coronary artery disease; CRC trans rs61931739 0.534 rs12372721 chr12:34175301 C/T cg26384229 chr12:38710491 ALG10B 0.56 7.04 0.36 1.11e-11 Morning vs. evening chronotype; CRC cis rs6667605 0.527 rs4422947 chr1:2539590 C/T cg18854424 chr1:2615690 NA 0.5 10.11 0.49 4.27e-21 Inflammatory bowel disease;Ulcerative colitis; CRC cis rs736801 0.808 rs72797303 chr5:131796163 T/C cg02033258 chr5:131593261 PDLIM4 0.34 5.97 0.31 6.14e-9 Breast cancer;Mosquito bite size; CRC cis rs728616 0.867 rs17879726 chr10:81698723 G/A cg11900509 chr10:81946545 ANXA11 -0.65 -6.71 -0.35 8.77e-11 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs10078 0.515 rs6872510 chr5:481610 T/C cg24955955 chr5:415729 AHRR 0.67 6.31 0.33 9.06e-10 Fat distribution (HIV); CRC trans rs7618501 1.000 rs34614773 chr3:49753003 T/G cg21582582 chr3:182698605 DCUN1D1 -0.56 -8.26 -0.41 3.59e-15 Intelligence (multi-trait analysis); CRC cis rs155076 0.711 rs4770131 chr13:21897468 A/G cg25811766 chr13:21894605 NA 0.55 6.51 0.34 2.87e-10 White matter hyperintensity burden; CRC cis rs7829975 0.714 rs4840362 chr8:8670082 C/G cg06636001 chr8:8085503 FLJ10661 -0.64 -9.94 -0.48 1.54e-20 Mood instability; CRC cis rs523522 0.962 rs2168319 chr12:120933217 C/T cg12219531 chr12:120966889 COQ5 0.62 8.4 0.42 1.34e-15 High light scatter reticulocyte count; CRC cis rs1568889 0.938 rs11601602 chr11:28233768 A/G cg06544937 chr11:28130018 METT5D1;KIF18A 0.78 9.87 0.48 2.72e-20 Bipolar disorder; CRC cis rs9611565 0.802 rs73176692 chr22:41785735 G/A cg06634786 chr22:41940651 POLR3H -0.66 -7.69 -0.39 1.7e-13 Vitiligo; CRC cis rs7512552 0.839 rs3896342 chr1:150411312 T/C cg15654264 chr1:150340011 RPRD2 0.6 8.31 0.42 2.61e-15 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); CRC cis rs1577917 0.804 rs2786854 chr6:86668740 C/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.45 -5.86 -0.31 1.1e-8 Response to antipsychotic treatment; CRC cis rs9733 0.596 rs72702523 chr1:150650425 G/T cg15448220 chr1:150897856 SETDB1 0.45 6.44 0.33 4.29e-10 Tonsillectomy; CRC cis rs4363385 0.747 rs9659623 chr1:152965158 C/T cg25856811 chr1:152973957 SPRR3 -0.26 -7.18 -0.37 4.77e-12 Inflammatory skin disease; CRC cis rs17532515 0.628 rs2321272 chr4:141465244 T/C cg09181644 chr4:141490428 UCP1 -0.32 -5.77 -0.3 1.86e-8 Select biomarker traits; CRC cis rs473651 0.503 rs515342 chr2:239367296 A/G cg18131467 chr2:239335373 ASB1 -0.71 -8.82 -0.44 6.8e-17 Multiple system atrophy; CRC cis rs2075371 1.000 rs2544221 chr7:133993014 G/C cg02659138 chr7:134003124 SLC35B4 0.42 7.37 0.38 1.41e-12 Mean platelet volume; CRC cis rs11971779 0.680 rs2355785 chr7:139070983 C/A cg23387468 chr7:139079360 LUC7L2 0.41 7.04 0.36 1.14e-11 Diisocyanate-induced asthma; CRC trans rs877282 0.898 rs2004478 chr10:770709 C/A cg22713356 chr15:30763199 NA 1.16 14.97 0.64 5.46e-39 Uric acid levels; CRC cis rs7843479 0.511 rs4379446 chr8:21777595 C/G cg08288130 chr8:21771540 DOK2 0.3 5.94 0.31 7.3e-9 Mean corpuscular volume; CRC cis rs428668 0.523 rs3926389 chr5:150677806 C/T cg14086364 chr5:150678334 SLC36A3 0.38 6.74 0.35 7.26e-11 Skin aging (microtopography measurement); CRC cis rs2898681 0.581 rs28618986 chr4:53677902 G/C cg00338735 chr4:53728038 RASL11B 0.38 5.71 0.3 2.46e-8 Optic nerve measurement (cup area); CRC cis rs6866344 0.697 rs6873150 chr5:178125704 G/A cg03877680 chr5:178157825 ZNF354A 0.75 11.02 0.52 3.08e-24 Neutrophil percentage of white cells; CRC cis rs1008375 0.900 rs10019460 chr4:17686337 T/C cg16339924 chr4:17578868 LAP3 -0.47 -6.05 -0.32 3.94e-9 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs1008375 1.000 rs10805359 chr4:17684886 A/G cg04450456 chr4:17643702 FAM184B 0.37 6.03 0.32 4.4e-9 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs8180040 0.739 rs4683320 chr3:47152992 C/T cg10298567 chr3:47292165 KIF9 -0.38 -6.13 -0.32 2.46e-9 Colorectal cancer; CRC trans rs9858542 0.953 rs9862080 chr3:49674458 A/G cg21582582 chr3:182698605 DCUN1D1 -0.57 -6.84 -0.35 3.77e-11 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs4332037 0.851 rs73050128 chr7:1961882 C/A cg23422044 chr7:1970798 MAD1L1 -0.65 -8.02 -0.4 1.82e-14 Bipolar disorder; CRC cis rs10193935 0.901 rs12620021 chr2:42477034 T/C cg27598129 chr2:42591480 NA -0.72 -7.95 -0.4 3e-14 Colonoscopy-negative controls vs population controls; CRC trans rs12438356 0.686 rs16952914 chr15:69477442 T/A cg26416341 chr12:54718712 COPZ1 0.64 5.96 0.31 6.33e-9 CTACK levels; CRC cis rs3858526 0.523 rs10742818 chr11:5882535 T/C cg02574844 chr11:5959923 NA -0.52 -7.61 -0.39 2.89e-13 DNA methylation (variation); CRC cis rs853679 0.517 rs9393896 chr6:28127703 C/T cg15845792 chr6:28175446 NA 1.04 13.89 0.61 7.67e-35 Depression; CRC cis rs4074493 0.963 rs6541251 chr1:231173596 T/C cg22172038 chr1:231176991 FAM89A 0.34 5.9 0.31 8.81e-9 Carotid plaque burden (smoking interaction); CRC cis rs10751667 0.666 rs6597958 chr11:978087 C/T cg01483505 chr11:975446 AP2A2 0.46 7.66 0.39 2.11e-13 Alzheimer's disease (late onset); CRC cis rs546131 0.928 rs483976 chr11:34840167 C/G cg11058730 chr11:34937778 PDHX;APIP 0.48 7.05 0.36 1.09e-11 Lung disease severity in cystic fibrosis; CRC cis rs12900413 0.562 rs28450767 chr15:90298228 A/G cg24249390 chr15:90295951 MESP1 -0.59 -9.39 -0.46 9.99e-19 Coronary artery aneurysm in Kawasaki disease; CRC cis rs12500482 0.935 rs2239736 chr4:2438929 T/C cg01601518 chr4:2404284 ZFYVE28 -0.37 -6.01 -0.31 5.05e-9 Cognitive function; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg05140079 chr16:57496545 POLR2C 0.48 6.74 0.35 7.05e-11 Anxiety disorder; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg09225691 chr3:98312547 CPOX 0.4 6.09 0.32 3.12e-9 Intelligence (multi-trait analysis); CRC trans rs3780486 0.718 rs73645257 chr9:33132354 C/T cg20290983 chr6:43655470 MRPS18A 0.97 12.55 0.57 8.98e-30 IgG glycosylation; CRC cis rs6502050 0.865 rs74480314 chr17:80117716 C/T cg25804541 chr17:80189381 SLC16A3 -0.31 -5.98 -0.31 5.73e-9 Life satisfaction; CRC cis rs2302777 0.507 rs9889716 chr17:38108298 A/G cg24910161 chr17:38119198 GSDMA -0.36 -5.94 -0.31 7.28e-9 Multiple myeloma (hyperdiploidy); CRC cis rs11123610 0.520 rs12711962 chr2:3717985 C/T cg00999904 chr2:3704751 ALLC -0.52 -6.59 -0.34 1.79e-10 Response to inhaled corticosteroid treatment in asthma (change in FEV1); CRC cis rs875971 1.000 rs2036264 chr7:65799904 G/A cg18912574 chr7:65842487 NCRNA00174 -0.36 -6.11 -0.32 2.74e-9 Aortic root size; CRC cis rs9916302 0.861 rs33933929 chr17:37426441 A/C cg07936489 chr17:37558343 FBXL20 -0.79 -11.81 -0.55 4.41e-27 Glomerular filtration rate (creatinine); CRC cis rs9914988 0.943 rs11658884 chr17:27132742 A/G cg20469991 chr17:27169893 C17orf63 0.61 7.35 0.38 1.56e-12 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs9807989 0.839 rs9808453 chr2:102971306 C/A cg03938978 chr2:103052716 IL18RAP 0.37 5.97 0.31 6.2e-9 Asthma; CRC cis rs2573652 0.674 rs11630583 chr15:100543355 G/A cg00587665 chr15:100533223 ADAMTS17 -0.38 -6.8 -0.35 4.85e-11 Height; CRC cis rs8067545 0.641 rs203450 chr17:19823070 C/T cg04132472 chr17:19861366 AKAP10 0.42 6.44 0.33 4.12e-10 Schizophrenia; CRC cis rs8180040 0.654 rs6773521 chr3:47234419 A/G cg02527881 chr3:46936655 PTH1R 0.35 6.11 0.32 2.83e-9 Colorectal cancer; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg12889510 chr2:204399188 RAPH1 0.49 6.93 0.36 2.29e-11 Thyroid stimulating hormone; CRC cis rs6502050 0.805 rs11077970 chr17:80085916 C/T cg09264619 chr17:80180166 NA 0.36 6.02 0.32 4.65e-9 Life satisfaction; CRC trans rs1814175 0.588 rs1721994 chr11:49914050 G/A cg03929089 chr4:120376271 NA -0.91 -16.07 -0.66 2.65e-43 Height; CRC cis rs28386778 0.897 rs2727327 chr17:61923422 G/A cg06873352 chr17:61820015 STRADA 0.79 15.0 0.64 4.13e-39 Prudent dietary pattern; CRC cis rs10504229 1.000 rs117231141 chr8:58185465 A/G cg01721255 chr8:58191610 C8orf71 0.49 6.17 0.32 2e-9 Developmental language disorder (linguistic errors); CRC cis rs28386778 0.897 rs8079818 chr17:61824667 C/G cg06601766 chr17:61851465 DDX42;CCDC47 0.45 6.1 0.32 2.9e-9 Prudent dietary pattern; CRC cis rs2404602 0.716 rs7164813 chr15:76708066 T/C cg03037974 chr15:76606532 NA 0.72 13.12 0.59 6.35e-32 Blood metabolite levels; CRC cis rs875971 0.545 rs316328 chr7:65608838 A/G cg03233332 chr7:66118400 NA 0.41 6.02 0.32 4.55e-9 Aortic root size; CRC cis rs9914988 0.943 rs4262997 chr17:27129562 A/G cg12682573 chr17:27188876 MIR451;MIR144 0.58 7.99 0.4 2.37e-14 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs875971 0.862 rs57866200 chr7:65565392 A/G cg00343986 chr7:65444356 GUSB -0.44 -6.31 -0.33 9.16e-10 Aortic root size; CRC cis rs7849270 1.000 rs932835 chr9:131887071 A/G cg13538475 chr9:131942899 NA -0.31 -6.03 -0.32 4.49e-9 Blood metabolite ratios; CRC cis rs10504229 0.681 rs11779172 chr8:58045538 A/G cg21724239 chr8:58056113 NA 0.53 7.05 0.36 1.06e-11 Developmental language disorder (linguistic errors); CRC cis rs2762353 0.574 rs16890999 chr6:25755583 A/G cg07061783 chr6:25882402 NA 0.5 6.39 0.33 5.67e-10 Blood metabolite levels; CRC trans rs7027930 0.524 rs10758738 chr9:611017 C/T cg27061366 chr19:13044373 FARSA 0.53 6.44 0.33 4.28e-10 Pulmonary function decline; CRC cis rs734999 0.545 rs10752748 chr1:2544640 G/A cg18854424 chr1:2615690 NA 0.4 7.64 0.39 2.42e-13 Ulcerative colitis; CRC cis rs7843479 0.965 rs11784535 chr8:21857787 G/A cg17168535 chr8:21777572 XPO7 0.55 8.71 0.43 1.54e-16 Mean corpuscular volume; CRC cis rs6952808 0.578 rs6949478 chr7:1841342 A/G cg02951883 chr7:2050386 MAD1L1 0.51 7.03 0.36 1.19e-11 Bipolar disorder and schizophrenia; CRC trans rs1814175 0.745 rs7483456 chr11:49774613 C/T cg11707556 chr5:10655725 ANKRD33B -0.42 -8.05 -0.41 1.5e-14 Height; CRC cis rs734999 0.545 rs12752515 chr1:2564465 T/C cg20673091 chr1:2541236 MMEL1 -0.36 -5.68 -0.3 2.99e-8 Ulcerative colitis; CRC cis rs9894429 0.646 rs9905639 chr17:79614154 A/G cg13777783 chr17:79615861 NA -0.31 -6.05 -0.32 3.89e-9 Eye color traits; CRC cis rs1008375 0.897 rs6820164 chr4:17630115 G/A cg16339924 chr4:17578868 LAP3 0.52 6.61 0.34 1.51e-10 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs1519814 0.956 rs6995843 chr8:121159867 C/T cg22335954 chr8:121166405 COL14A1 -0.59 -6.83 -0.35 4.11e-11 Breast cancer; CRC cis rs6120849 0.754 rs6120797 chr20:33606002 G/A cg08999081 chr20:33150536 PIGU 0.45 5.87 0.31 1.05e-8 Protein C levels; CRC trans rs2665103 0.610 rs1972460 chr15:82530630 A/G cg04831495 chr15:85060580 GOLGA6L5 -0.4 -6.11 -0.32 2.86e-9 Intelligence (multi-trait analysis); CRC cis rs6495122 0.644 rs62029217 chr15:75261899 C/T cg18612461 chr15:75251733 NA 0.48 7.26 0.37 2.88e-12 Caffeine consumption;Diastolic blood pressure;Coffee consumption; CRC cis rs7224685 0.501 rs781839 chr17:3961489 C/T cg09597638 chr17:3907349 NA 0.63 11.41 0.53 1.28e-25 Type 2 diabetes; CRC cis rs7512552 0.803 rs11205385 chr1:150476516 G/A cg15654264 chr1:150340011 RPRD2 0.61 8.45 0.42 9.5e-16 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); CRC cis rs6502050 0.835 rs35555954 chr17:80122438 T/C cg09264619 chr17:80180166 NA -0.34 -5.71 -0.3 2.56e-8 Life satisfaction; CRC trans rs12310956 0.532 rs11052920 chr12:33955891 T/G cg26384229 chr12:38710491 ALG10B 0.46 6.27 0.33 1.16e-9 Morning vs. evening chronotype; CRC trans rs7937682 0.814 rs1619652 chr11:111469757 G/A cg18187862 chr3:45730750 SACM1L 0.44 6.32 0.33 8.48e-10 Primary sclerosing cholangitis; CRC cis rs9527 0.615 rs17725614 chr10:104685493 G/C cg04362960 chr10:104952993 NT5C2 0.59 8.45 0.42 9.26e-16 Arsenic metabolism; CRC trans rs6076960 0.684 rs3852947 chr20:6255341 A/G cg17788362 chr6:86352627 SYNCRIP 0.55 7.87 0.4 5.26e-14 Smooth-surface caries; CRC trans rs1814175 0.653 rs10839480 chr11:50034556 C/T cg11707556 chr5:10655725 ANKRD33B -0.42 -8.03 -0.4 1.75e-14 Height; CRC cis rs2440129 0.611 rs1126667 chr17:6902760 C/T cg05215272 chr17:6899095 ALOX12 -0.58 -10.64 -0.51 6.59e-23 Tonsillectomy; CRC cis rs9486715 1.000 rs9486725 chr6:97061159 C/T cg18709589 chr6:96969512 KIAA0776 -0.51 -7.52 -0.38 5.13e-13 Headache; CRC cis rs17767392 0.834 rs55863348 chr14:71724293 C/T cg13720639 chr14:72061746 SIPA1L1 -0.51 -6.18 -0.32 1.94e-9 Mitral valve prolapse; CRC cis rs875971 1.000 rs697970 chr7:65560052 G/C cg00343986 chr7:65444356 GUSB -0.46 -6.75 -0.35 6.85e-11 Aortic root size; CRC cis rs11098499 0.863 rs6858777 chr4:120475966 A/G cg09307838 chr4:120376055 NA 0.67 9.99 0.48 1.1e-20 Corneal astigmatism; CRC cis rs868943 0.511 rs12204724 chr6:116532430 C/T cg15226275 chr6:116381976 FRK 0.26 6.12 0.32 2.7e-9 Total cholesterol levels; CRC cis rs1129187 0.935 rs9986447 chr6:42942779 C/T cg27588902 chr6:42928151 GNMT 0.38 6.59 0.34 1.79e-10 Alzheimer's disease in APOE e4+ carriers; CRC cis rs853679 0.760 rs9468317 chr6:28198456 A/G cg12273811 chr6:28175739 NA 0.54 6.01 0.31 4.89e-9 Depression; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg00167275 chr10:88854588 FAM35A;GLUD1 0.42 6.86 0.35 3.45e-11 Liver disease severity in Alagille syndrome; CRC cis rs9611565 0.729 rs202654 chr22:41841034 G/A cg06634786 chr22:41940651 POLR3H 0.44 5.64 0.3 3.6e-8 Vitiligo; CRC cis rs13108904 0.870 rs11727987 chr4:1261435 A/G cg21620606 chr4:1342894 KIAA1530 0.38 6.45 0.33 4.07e-10 Obesity-related traits; CRC cis rs9517320 1.000 rs9584857 chr13:99128572 T/C cg07423050 chr13:99094983 FARP1 0.4 6.39 0.33 5.6e-10 Longevity; CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg16211055 chr1:228594250 TRIM11 -0.51 -6.15 -0.32 2.3e-9 Diisocyanate-induced asthma; CRC cis rs67311347 0.955 rs6782746 chr3:40510592 A/G cg09455208 chr3:40491958 NA -0.48 -9.5 -0.46 4.65e-19 Renal cell carcinoma; CRC cis rs17345786 0.954 rs17508319 chr3:101318903 G/A cg12386194 chr3:101231763 SENP7 0.55 7.23 0.37 3.51e-12 Colonoscopy-negative controls vs population controls; CRC cis rs3091242 0.933 rs10903130 chr1:25769221 A/T cg23205692 chr1:25664452 TMEM50A 0.4 5.68 0.3 2.93e-8 Erythrocyte sedimentation rate; CRC cis rs244731 0.959 rs6556307 chr5:176641434 C/T cg05207973 chr5:176823642 SLC34A1 0.4 5.76 0.3 1.91e-8 Urate levels in lean individuals; CRC cis rs6912958 0.559 rs107690 chr6:88069352 A/G cg08069147 chr6:88032118 GJB7;C6orf162 -0.67 -10.94 -0.52 5.79e-24 Monocyte percentage of white cells; CRC cis rs6502050 0.699 rs9901808 chr17:80107814 C/T cg19223190 chr17:80058835 NA 0.38 6.14 0.32 2.39e-9 Life satisfaction; CRC cis rs1862618 0.713 rs832549 chr5:56183542 C/T cg24531977 chr5:56204891 C5orf35 -0.84 -10.92 -0.52 6.54e-24 Initial pursuit acceleration; CRC cis rs1448094 0.510 rs1993806 chr12:86147151 T/C cg19622623 chr12:86230825 RASSF9 0.4 6.15 0.32 2.22e-9 Major depressive disorder; CRC cis rs860295 0.541 rs11264359 chr1:155282829 A/G cg02153340 chr1:155202674 NA -0.47 -6.27 -0.33 1.11e-9 Body mass index; CRC cis rs1448094 0.845 rs7132262 chr12:86346304 C/T cg25456477 chr12:86230367 RASSF9 0.33 5.63 0.3 3.87e-8 Major depressive disorder; CRC cis rs60843830 0.928 rs55742348 chr2:217563 T/A cg25945732 chr2:264204 ACP1;SH3YL1 0.73 11.66 0.54 1.58e-26 Spherical equivalent (joint analysis main effects and education interaction); CRC cis rs2011503 0.941 rs76944848 chr19:19417512 C/T cg11584989 chr19:19387371 SF4 0.55 5.84 0.31 1.22e-8 Bipolar disorder; CRC trans rs10982213 0.830 rs2274163 chr9:117188714 C/T cg25880573 chr1:24073129 TCEB3 0.46 7.28 0.37 2.51e-12 Interleukin-6 levels; CRC cis rs9837602 0.529 rs793458 chr3:99520169 C/T cg08350549 chr3:99591722 C3orf26;FILIP1L;MIR548G -0.38 -5.87 -0.31 1.05e-8 Breast cancer; CRC cis rs910316 1.000 rs4903275 chr14:75512509 C/T cg08847533 chr14:75593920 NEK9 0.95 18.15 0.71 1.66e-51 Height; CRC cis rs704795 0.836 rs1647281 chr2:27612938 G/C cg22903471 chr2:27725779 GCKR -0.37 -6.08 -0.32 3.41e-9 Menopause (age at onset); CRC cis rs7618915 0.501 rs2109634 chr3:52752075 T/G cg08222913 chr3:52553049 STAB1 -0.33 -6.12 -0.32 2.64e-9 Bipolar disorder; CRC cis rs9486719 0.895 rs11152960 chr6:96900398 A/G cg06623918 chr6:96969491 KIAA0776 -0.81 -9.47 -0.46 5.55e-19 Migraine;Coronary artery disease; CRC trans rs61931739 0.500 rs10772163 chr12:34532950 T/C cg13010199 chr12:38710504 ALG10B 0.45 6.52 0.34 2.65e-10 Morning vs. evening chronotype; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg15164871 chr12:123380523 VPS37B 0.4 6.4 0.33 5.45e-10 Liver disease severity in Alagille syndrome; CRC cis rs7647973 0.769 rs11130181 chr3:49109919 G/A cg07636037 chr3:49044803 WDR6 0.85 11.43 0.53 1.02e-25 Menarche (age at onset); CRC cis rs9368481 0.678 rs62402024 chr6:26923976 T/C cg05192639 chr6:26864778 GUSBL1 0.34 6.2 0.32 1.73e-9 Autism spectrum disorder or schizophrenia; CRC cis rs853679 0.517 rs12332979 chr6:28141548 T/G cg02683197 chr6:28174875 NA 0.88 10.83 0.51 1.42e-23 Depression; CRC cis rs11622475 0.953 rs6576012 chr14:104400159 T/C cg20488157 chr14:104394430 TDRD9 -0.67 -9.55 -0.47 2.98e-19 Bipolar disorder; CRC cis rs7659604 0.967 rs28529384 chr4:122664215 T/C cg19748678 chr4:122722346 EXOSC9 0.55 8.85 0.44 5.3e-17 Type 2 diabetes; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg19729279 chr5:133861951 PHF15 0.5 6.71 0.35 8.37e-11 Thyroid stimulating hormone; CRC cis rs2013441 0.931 rs12937827 chr17:20033202 G/C cg13482628 chr17:19912719 NA 0.41 6.36 0.33 6.66e-10 Obesity-related traits; CRC cis rs6500602 0.627 rs3848372 chr16:4587875 C/A cg14951292 chr16:4525986 HMOX2;NMRAL1 0.59 8.36 0.42 1.85e-15 Schizophrenia; CRC trans rs11098499 0.954 rs11935596 chr4:120412457 G/C cg25214090 chr10:38739885 LOC399744 0.66 10.54 0.5 1.46e-22 Corneal astigmatism; CRC cis rs2404602 0.735 rs11072598 chr15:76764788 T/C cg23625390 chr15:77176239 SCAPER -0.84 -12.8 -0.58 1.04e-30 Blood metabolite levels; CRC cis rs6500395 0.890 rs11861666 chr16:48679914 G/T cg04672837 chr16:48644449 N4BP1 0.42 6.01 0.31 4.84e-9 Response to tocilizumab in rheumatoid arthritis; CRC cis rs853679 0.517 rs1947863 chr6:28099344 G/A cg12963246 chr6:28129442 ZNF389 0.49 5.78 0.3 1.73e-8 Depression; CRC cis rs9925964 0.935 rs4527034 chr16:31131614 A/G cg03418659 chr16:31128414 MYST1 -0.48 -7.15 -0.37 5.49e-12 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs1355223 0.583 rs2941044 chr11:34867444 A/C cg11058730 chr11:34937778 PDHX;APIP 0.72 11.85 0.55 3.3e-27 Systemic lupus erythematosus and Systemic sclerosis; CRC cis rs12701220 0.553 rs13245507 chr7:1163694 C/T cg02733842 chr7:1102375 C7orf50 -0.76 -9.44 -0.46 7.15e-19 Bronchopulmonary dysplasia; CRC cis rs7781557 0.638 rs55781834 chr7:102572433 A/C cg18108683 chr7:102477205 FBXL13 -0.48 -5.66 -0.3 3.3e-8 Colorectal adenoma (advanced); CRC trans rs7615952 0.512 rs11929125 chr3:125359443 G/A cg07211511 chr3:129823064 LOC729375 -0.63 -8.76 -0.43 1.03e-16 Blood pressure (smoking interaction); CRC cis rs703842 1.000 rs10877012 chr12:58162085 G/T cg00677455 chr12:58241039 CTDSP2 0.7 9.51 0.46 4.15e-19 Multiple sclerosis; CRC cis rs4713118 0.868 rs742047 chr6:27739380 A/G cg15786705 chr6:28176104 NA 0.61 6.75 0.35 6.5e-11 Parkinson's disease; CRC cis rs35110281 0.591 rs162390 chr21:44936826 C/T cg01579765 chr21:45077557 HSF2BP -0.37 -6.93 -0.36 2.18e-11 Mean corpuscular volume; CRC cis rs875971 0.660 rs801190 chr7:66033033 C/T cg00343986 chr7:65444356 GUSB -0.5 -7.43 -0.38 9.64e-13 Aortic root size; CRC cis rs17065868 0.764 rs55670821 chr13:45028851 A/C cg10246903 chr13:45222710 NA 0.54 5.66 0.3 3.29e-8 Antineutrophil cytoplasmic antibody-associated vasculitis; CRC cis rs6735179 0.529 rs1364648 chr2:1754932 A/G cg19300414 chr2:1746591 PXDN -0.39 -6.4 -0.33 5.35e-10 Response to antipsychotic treatment; CRC cis rs9611565 0.512 rs4820446 chr22:42215684 C/T cg06481639 chr22:41940642 POLR3H -0.63 -6.96 -0.36 1.8e-11 Vitiligo; CRC cis rs12410462 0.681 rs74582965 chr1:227610126 C/T cg04117972 chr1:227635322 NA 0.77 8.03 0.4 1.73e-14 Major depressive disorder; CRC cis rs12762955 0.608 rs7922760 chr10:1156815 G/C cg20503657 chr10:835505 NA -0.58 -8.51 -0.42 6.14e-16 Response to angiotensin II receptor blocker therapy; CRC cis rs995000 0.868 rs1168002 chr1:62934308 A/G cg19896129 chr1:63156450 NA -0.39 -5.98 -0.31 5.97e-9 Triglyceride levels; CRC cis rs1008375 0.900 rs6812675 chr4:17597549 A/G cg16339924 chr4:17578868 LAP3 0.63 8.06 0.41 1.42e-14 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs477895 0.713 rs11607165 chr11:63963947 T/G cg18225595 chr11:63971243 STIP1 0.61 8.14 0.41 7.99e-15 Mean platelet volume; CRC cis rs11148252 0.846 rs7333451 chr13:53047709 G/A cg12458913 chr13:53173898 NA 0.56 8.7 0.43 1.66e-16 Lewy body disease; CRC cis rs78456975 1.000 rs10208340 chr2:1563100 G/A cg26248373 chr2:1572462 NA -0.66 -7.2 -0.37 4.09e-12 Placebo response in major depressive disorder (% change in symptom score); CRC cis rs10078 0.515 rs890984 chr5:479540 A/G cg24955955 chr5:415729 AHRR 0.63 6.15 0.32 2.26e-9 Fat distribution (HIV); CRC cis rs1728785 1.000 rs1645976 chr16:68563509 T/C cg02972257 chr16:68554789 NA -0.58 -7.08 -0.36 9.03e-12 Ulcerative colitis; CRC cis rs4654899 0.931 rs2275468 chr1:21220375 T/G cg02927042 chr1:21476669 EIF4G3 0.42 6.75 0.35 6.54e-11 Superior frontal gyrus grey matter volume; CRC cis rs7072216 0.726 rs4474372 chr10:100164571 C/T cg26618903 chr10:100175079 PYROXD2 -0.54 -8.91 -0.44 3.57e-17 Metabolite levels; CRC trans rs7944735 0.607 rs34895872 chr11:48021778 A/G cg03929089 chr4:120376271 NA 0.53 6.93 0.36 2.28e-11 Intraocular pressure; CRC cis rs881375 0.967 rs1860823 chr9:123659304 T/C cg00246817 chr9:123691163 NA -0.47 -5.97 -0.31 6.26e-9 Rheumatoid arthritis; CRC trans rs6598955 0.572 rs12089219 chr1:26638751 C/T cg07461501 chr17:79650226 HGS;ARL16 -0.55 -6.45 -0.34 4.03e-10 Obesity-related traits; CRC cis rs1448094 0.533 rs10863078 chr12:86152672 C/T cg02569458 chr12:86230093 RASSF9 -0.48 -7.92 -0.4 3.61e-14 Major depressive disorder; CRC cis rs9894429 0.634 rs11655346 chr17:79572399 A/G cg21984481 chr17:79567631 NPLOC4 0.45 7.87 0.4 5.32e-14 Eye color traits; CRC cis rs3771570 1.000 rs62193204 chr2:242315443 A/G cg21155796 chr2:242212141 HDLBP 0.65 7.01 0.36 1.34e-11 Prostate cancer; CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg09658987 chr6:83903672 PGM3;RWDD2A -0.5 -6.23 -0.32 1.39e-9 Diisocyanate-induced asthma; CRC cis rs1862618 1.000 rs1862618 chr5:56096315 C/G cg24531977 chr5:56204891 C5orf35 -0.74 -10.05 -0.48 6.86e-21 Initial pursuit acceleration; CRC trans rs12478296 1.000 rs57603292 chr2:243028537 G/A cg18288967 chr1:45987694 PRDX1 0.63 6.81 0.35 4.6e-11 Obesity-related traits; CRC cis rs12142240 0.659 rs67547686 chr1:46832229 G/C cg14993813 chr1:46806288 NSUN4 -0.49 -6.26 -0.33 1.21e-9 Menopause (age at onset); CRC cis rs933688 1.000 rs10474353 chr5:90732285 A/C cg26981201 chr5:90679533 LOC100129716;ARRDC3 1.06 16.82 0.68 3e-46 Smoking behavior; CRC cis rs7259376 0.936 rs7247220 chr19:22589489 C/G cg02657401 chr19:22469223 NA 0.31 6.72 0.35 8.02e-11 Menopause (age at onset); CRC cis rs763014 0.932 rs2384974 chr16:651279 C/G cg00802000 chr16:706648 WDR90 -0.44 -6.48 -0.34 3.28e-10 Height; CRC cis rs62229266 0.804 rs880221 chr21:37420785 C/T cg12218747 chr21:37451666 NA -0.43 -7.41 -0.38 1.09e-12 Mitral valve prolapse; CRC cis rs274567 0.501 rs272855 chr5:131687175 C/T cg20512303 chr5:131592959 PDLIM4 0.4 6.65 0.34 1.22e-10 Blood metabolite levels; CRC cis rs11098499 0.657 rs71614442 chr4:120379346 C/T cg09307838 chr4:120376055 NA 0.7 10.87 0.51 1.05e-23 Corneal astigmatism; CRC cis rs1552244 0.832 rs73024591 chr3:10203194 A/T cg10729496 chr3:10149963 C3orf24 0.59 6.86 0.35 3.42e-11 Alzheimer's disease; CRC cis rs372883 0.563 rs1153293 chr21:30691325 C/T cg24692254 chr21:30365293 RNF160 0.65 9.58 0.47 2.46e-19 Pancreatic cancer; CRC trans rs1814175 0.715 rs1722007 chr11:49897319 T/C cg21153622 chr11:89784906 NA -0.37 -5.98 -0.31 5.7e-9 Height; CRC cis rs9398803 0.865 rs9388495 chr6:126782457 G/A cg19875578 chr6:126661172 C6orf173 0.41 5.64 0.3 3.62e-8 Male-pattern baldness; CRC cis rs11105298 0.891 rs10858909 chr12:89935387 C/T cg08166232 chr12:89918718 WDR51B;GALNT4 -0.59 -7.25 -0.37 3.06e-12 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; CRC cis rs282587 0.569 rs385656 chr13:113413234 C/T cg04656015 chr13:113407548 ATP11A 0.51 6.45 0.34 3.94e-10 Glycated hemoglobin levels; CRC cis rs6088580 0.524 rs1853056 chr20:33262058 C/T cg08999081 chr20:33150536 PIGU -0.37 -5.69 -0.3 2.84e-8 Glomerular filtration rate (creatinine); CRC cis rs9486719 0.790 rs2499790 chr6:96845078 G/A cg06623918 chr6:96969491 KIAA0776 0.79 8.57 0.43 4.23e-16 Migraine;Coronary artery disease; CRC cis rs28386778 0.805 rs9911714 chr17:61828952 G/A cg25654072 chr17:61904446 PSMC5;FTSJ3 0.72 11.28 0.53 3.65e-25 Prudent dietary pattern; CRC cis rs9322193 0.923 rs10872645 chr6:150063976 G/A cg07701084 chr6:150067640 NUP43 0.47 6.7 0.35 9.25e-11 Lung cancer; CRC cis rs651907 0.557 rs11712748 chr3:101383562 G/A cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.68 9.57 0.47 2.63e-19 Colorectal cancer; CRC cis rs13382862 0.862 rs340595 chr2:20889714 A/G cg14780466 chr2:20870812 GDF7 -0.33 -6.52 -0.34 2.65e-10 Abdominal aortic aneurysm; CRC cis rs12900463 0.813 rs306198 chr15:85405369 C/T cg17507749 chr15:85114479 UBE2QP1 -0.45 -6.13 -0.32 2.57e-9 Adverse response to chemotherapy (neutropenia/leucopenia) (gemcitabine); CRC cis rs853679 0.517 rs9368556 chr6:28131153 T/C cg18032046 chr6:28092343 ZSCAN16 -0.51 -5.93 -0.31 7.47e-9 Depression; CRC cis rs7105860 1 rs7105860 chr11:27306364 G/C cg10370305 chr11:27303972 NA 0.37 6.02 0.31 4.69e-9 Total body bone mineral density; CRC cis rs1572438 0.839 rs6597297 chr6:864484 C/T cg21062780 chr6:887772 NA 0.34 5.67 0.3 3.16e-8 Aging; CRC cis rs17253792 0.822 rs74412558 chr14:56054311 C/T cg01858014 chr14:56050164 KTN1 -0.88 -7.07 -0.36 9.07e-12 Putamen volume; CRC cis rs57221529 0.766 rs12522140 chr5:587261 C/A cg14541582 chr5:601475 NA -0.37 -7.17 -0.37 5.13e-12 Lung disease severity in cystic fibrosis; CRC cis rs875971 1.000 rs55962648 chr7:65625751 C/G cg00343986 chr7:65444356 GUSB -0.46 -6.75 -0.35 6.76e-11 Aortic root size; CRC cis rs703842 0.642 rs73123375 chr12:58063664 C/T cg15848620 chr12:58087721 OS9 0.54 6.25 0.33 1.3e-9 Multiple sclerosis; CRC cis rs910316 1.000 rs12589815 chr14:75544101 C/T cg08847533 chr14:75593920 NEK9 0.93 17.79 0.7 4.26e-50 Height; CRC cis rs877282 0.947 rs7475589 chr10:767479 C/G cg06581033 chr10:766294 NA -0.52 -5.77 -0.3 1.84e-8 Uric acid levels; CRC cis rs7412746 0.611 rs16827671 chr1:150738759 T/C cg15448220 chr1:150897856 SETDB1 0.51 7.15 0.37 5.51e-12 Melanoma; CRC cis rs4731207 0.698 rs10243736 chr7:124458966 A/G cg23710748 chr7:124431027 NA 0.38 6.08 0.32 3.42e-9 Cutaneous malignant melanoma; CRC cis rs7927771 0.965 rs11039416 chr11:47846711 G/A cg05585544 chr11:47624801 NA -0.61 -10.84 -0.51 1.25e-23 Subjective well-being; CRC cis rs801193 0.548 rs6975044 chr7:66227482 C/T cg12463550 chr7:65579703 CRCP 0.45 6.05 0.32 4.02e-9 Aortic root size; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg10967178 chr1:6454278 ACOT7 0.48 7.42 0.38 1.02e-12 Response to antipsychotic treatment; CRC cis rs7927771 0.697 rs11039307 chr11:47611152 C/T cg18512352 chr11:47633146 NA -0.37 -7.34 -0.38 1.7e-12 Subjective well-being; CRC cis rs10174077 0.874 rs6750342 chr2:152485754 A/G cg19508488 chr2:152266495 RIF1 0.49 6.95 0.36 1.91e-11 Squamous cell lung carcinoma; CRC cis rs875971 0.522 rs4502988 chr7:65297746 A/G cg18876405 chr7:65276391 NA 0.65 11.71 0.54 1.06e-26 Aortic root size; CRC trans rs2832077 0.883 rs35672956 chr21:30189042 T/C cg14791747 chr16:20752902 THUMPD1 0.53 6.38 0.33 6e-10 Cognitive test performance; CRC cis rs10193935 0.901 rs3755304 chr2:42589921 A/G cg27598129 chr2:42591480 NA 0.56 6.27 0.33 1.11e-9 Colonoscopy-negative controls vs population controls; CRC trans rs7615952 0.688 rs12638224 chr3:125541320 C/T cg07211511 chr3:129823064 LOC729375 -0.91 -13.25 -0.59 2.05e-32 Blood pressure (smoking interaction); CRC cis rs6961069 0.777 rs1761667 chr7:80244939 G/A cg04458919 chr7:80252533 CD36 0.36 6.42 0.33 4.86e-10 Platelet count; CRC cis rs6952808 0.624 rs60137119 chr7:2083664 A/G cg00106254 chr7:1943704 MAD1L1 -0.45 -6.17 -0.32 1.97e-9 Bipolar disorder and schizophrenia; CRC cis rs938554 0.558 rs4697701 chr4:9946095 C/T cg00071950 chr4:10020882 SLC2A9 -0.43 -6.45 -0.33 4.07e-10 Blood metabolite levels; CRC cis rs10504229 1.000 rs67237174 chr8:58175776 T/C cg24829409 chr8:58192753 C8orf71 -0.68 -11.28 -0.53 3.57e-25 Developmental language disorder (linguistic errors); CRC cis rs812925 0.855 rs777592 chr2:61418343 G/C cg10580144 chr2:61372316 C2orf74 0.33 6.63 0.34 1.38e-10 Immature fraction of reticulocytes; CRC cis rs2952156 1.000 rs2643195 chr17:37853118 A/G cg07936489 chr17:37558343 FBXL20 -0.42 -5.75 -0.3 2.03e-8 Asthma; CRC cis rs11690935 0.959 rs35391289 chr2:172634983 A/C cg13550731 chr2:172543902 DYNC1I2 -1.06 -16.91 -0.68 1.33e-46 Schizophrenia; CRC trans rs4698169 0.510 rs675984 chr4:17123821 A/G cg01542423 chr8:126668119 NA 0.38 6.09 0.32 3.2e-9 Temperament (bipolar disorder); CRC cis rs7487075 0.820 rs4586238 chr12:46719827 T/C cg22049899 chr12:47219821 SLC38A4 0.33 6.16 0.32 2.11e-9 Itch intensity from mosquito bite; CRC cis rs2739330 0.731 rs4822450 chr22:24242887 C/T cg10150615 chr22:24372951 LOC391322 -0.56 -8.37 -0.42 1.64e-15 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs1799949 0.931 rs34410138 chr17:41279770 A/G cg25072359 chr17:41440525 NA 0.45 6.83 0.35 4.17e-11 Menopause (age at onset); CRC cis rs2739330 0.731 rs4822450 chr22:24242887 C/T cg10819733 chr22:24237672 NA -0.37 -6.35 -0.33 6.96e-10 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs1552244 1.000 rs67006488 chr3:10152993 T/C cg00166722 chr3:10149974 C3orf24 0.7 9.21 0.45 3.89e-18 Alzheimer's disease; CRC cis rs6840360 0.806 rs13149588 chr4:152717757 C/T cg09659197 chr4:152720779 NA -0.5 -10.46 -0.5 2.74e-22 Intelligence (multi-trait analysis); CRC trans rs10982213 0.830 rs2274163 chr9:117188714 C/T cg23355997 chr17:7154831 DULLARD;C17orf81 0.4 6.06 0.32 3.8e-9 Interleukin-6 levels; CRC cis rs10991814 0.920 rs79799877 chr9:94036245 G/A cg14446406 chr9:93919335 NA 0.58 6.46 0.34 3.77e-10 Neutrophil percentage of granulocytes; CRC trans rs11992162 0.967 rs7461062 chr8:11831948 T/C cg06636001 chr8:8085503 FLJ10661 0.42 6.02 0.31 4.67e-9 Monocyte count; CRC cis rs13064411 0.696 rs6787026 chr3:113162117 A/G cg10517650 chr3:113235015 CCDC52 -0.37 -5.73 -0.3 2.24e-8 Response to simvastatin treatment (PCSK9 protein level change); CRC cis rs440932 1.000 rs440932 chr8:9026929 T/C cg06636001 chr8:8085503 FLJ10661 0.58 8.37 0.42 1.73e-15 High light scatter reticulocyte percentage of red cells; CRC cis rs10751667 0.600 rs1128413 chr11:1010694 C/T cg23136738 chr11:925521 AP2A2 -0.39 -6.03 -0.32 4.37e-9 Alzheimer's disease (late onset); CRC trans rs7618501 0.966 rs2352974 chr3:49890613 C/T cg21659725 chr3:3221576 CRBN 0.84 15.44 0.65 7.85e-41 Intelligence (multi-trait analysis); CRC trans rs916888 0.821 rs70602 chr17:44859715 T/C cg01341218 chr17:43662625 NA -0.83 -9.39 -0.46 1.03e-18 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs1046896 0.553 rs1044661 chr17:80901020 G/A cg08200770 chr17:80723486 TBCD -0.43 -6.59 -0.34 1.79e-10 Glycated hemoglobin levels; CRC cis rs1670533 1.000 rs28562028 chr4:1055115 G/A cg27284194 chr4:1044797 NA 0.5 6.2 0.32 1.66e-9 Recombination rate (females); CRC cis rs1348850 0.872 rs4893824 chr2:178298104 G/A cg02961200 chr2:178257176 LOC100130691;AGPS 0.57 7.86 0.4 5.41e-14 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs11229555 0.645 rs12805062 chr11:58214584 A/G cg15696309 chr11:58395628 NA -0.82 -10.31 -0.49 8.59e-22 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; CRC trans rs61931739 0.534 rs10844801 chr12:34230940 A/T cg26384229 chr12:38710491 ALG10B 0.55 7.05 0.36 1.03e-11 Morning vs. evening chronotype; CRC cis rs11650494 0.710 rs73987293 chr17:47474728 A/G cg08112188 chr17:47440006 ZNF652 0.69 6.28 0.33 1.05e-9 Prostate cancer; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg00648153 chr6:74364149 SLC17A5 0.5 6.44 0.33 4.25e-10 Thyroid stimulating hormone; CRC cis rs7666738 0.830 rs4292341 chr4:98959724 C/T cg17366294 chr4:99064904 C4orf37 0.38 6.15 0.32 2.24e-9 Colonoscopy-negative controls vs population controls; CRC cis rs6582630 0.519 rs12372510 chr12:38293074 T/C cg13010199 chr12:38710504 ALG10B 0.47 6.37 0.33 6.37e-10 Drug-induced liver injury (flucloxacillin); CRC cis rs66573146 0.803 rs59742225 chr4:6969942 C/T cg00086871 chr4:6988644 TBC1D14 0.95 7.07 0.36 9.4e-12 Granulocyte percentage of myeloid white cells; CRC cis rs7904985 1.000 rs10887586 chr10:88113521 G/A cg07322936 chr10:88137208 NA -0.49 -6.55 -0.34 2.22e-10 Barrett's esophagus; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg21587861 chr12:32260103 BICD1 0.39 5.96 0.31 6.33e-9 Intelligence (multi-trait analysis); CRC cis rs7937840 0.581 rs4963462 chr11:61886672 A/T cg01969543 chr11:61895209 INCENP 0.47 6.47 0.34 3.52e-10 Breast cancer; CRC cis rs7216064 1.000 rs6504543 chr17:65837659 T/C cg12091567 chr17:66097778 LOC651250 -0.63 -7.66 -0.39 2.05e-13 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CRC cis rs7914558 1.000 rs943036 chr10:104836047 T/C cg04362960 chr10:104952993 NT5C2 0.59 8.87 0.44 4.73e-17 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs9921222 0.500 rs11645742 chr16:367516 C/T cg08923669 chr16:420230 MRPL28 -0.58 -7.37 -0.38 1.43e-12 Bone mineral density (spine);Bone mineral density; CRC cis rs514406 0.698 rs511599 chr1:53362818 T/C cg27535305 chr1:53392650 SCP2 -0.43 -7.59 -0.39 3.24e-13 Monocyte count; CRC trans rs11098499 0.863 rs1480936 chr4:120462861 C/T cg25214090 chr10:38739885 LOC399744 0.65 10.46 0.5 2.74e-22 Corneal astigmatism; CRC cis rs9611519 0.964 rs20551 chr22:41548008 A/G cg03806693 chr22:41940476 POLR3H -0.65 -8.08 -0.41 1.29e-14 Neuroticism; CRC cis rs11098499 0.909 rs7681978 chr4:120383775 T/C cg24375607 chr4:120327624 NA 0.5 7.72 0.39 1.4e-13 Corneal astigmatism; CRC cis rs8031584 0.678 rs3122 chr15:31170290 A/T cg08704250 chr15:31115839 NA 0.53 9.33 0.46 1.58e-18 Huntington's disease progression; CRC cis rs12497850 1.000 rs12493578 chr3:48730116 C/T cg07636037 chr3:49044803 WDR6 -0.94 -16.1 -0.66 2.13e-43 Parkinson's disease; CRC cis rs12474201 1.000 rs12474201 chr2:46921285 C/T cg06386533 chr2:46925753 SOCS5 0.79 13.44 0.6 4.04e-33 Height; CRC cis rs17270561 0.609 rs4712968 chr6:25760344 T/C cg17691542 chr6:26056736 HIST1H1C 0.64 8.14 0.41 8.02e-15 Iron status biomarkers; CRC cis rs636291 0.517 rs55935829 chr1:10540926 A/T cg17425144 chr1:10567563 PEX14 0.53 12.05 0.55 6.18e-28 Prostate cancer; CRC cis rs611744 0.647 rs864166 chr8:109249300 C/G cg18478394 chr8:109455254 TTC35 0.37 5.78 0.3 1.75e-8 Dupuytren's disease; CRC cis rs17067123 0.614 rs2383271 chr4:180071469 G/A cg26610307 chr4:180072759 NA -0.57 -6.87 -0.35 3.16e-11 Response to hepatitis C treatment; CRC cis rs7586879 0.575 rs6706316 chr2:25128351 C/G cg04586622 chr2:25135609 ADCY3 -0.54 -10.22 -0.49 1.75e-21 Body mass index; CRC cis rs898097 0.578 rs8069697 chr17:80908110 T/C cg19046167 chr17:80928561 B3GNTL1 0.47 8.04 0.41 1.66e-14 Breast cancer; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg02472543 chr2:217277071 SMARCAL1 0.47 6.51 0.34 2.81e-10 Response to antipsychotic treatment; CRC cis rs9354308 0.933 rs55672811 chr6:66571730 G/A cg07460842 chr6:66804631 NA 0.48 6.0 0.31 5.07e-9 Metabolite levels; CRC cis rs9787249 0.915 rs58589165 chr1:40213670 A/T cg24920358 chr1:40204285 PPIE 0.57 8.56 0.43 4.54e-16 Blood protein levels; CRC cis rs344364 0.511 rs56077812 chr16:1948870 T/G cg09830162 chr16:1889614 FAHD1;C16orf73 -0.77 -9.36 -0.46 1.32e-18 Glomerular filtration rate in chronic kidney disease; CRC trans rs7395662 0.890 rs4882133 chr11:48593450 T/C cg21153622 chr11:89784906 NA -0.45 -7.27 -0.37 2.58e-12 HDL cholesterol; CRC cis rs910316 1.000 rs12435391 chr14:75601737 A/G cg11812906 chr14:75593930 NEK9 0.61 9.63 0.47 1.64e-19 Height; CRC cis rs172166 0.694 rs203893 chr6:28062066 C/A cg02683197 chr6:28174875 NA 0.66 9.16 0.45 5.53e-18 Cardiac Troponin-T levels; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg15358743 chr18:56807035 SEC11C 0.49 7.32 0.37 1.9e-12 Response to antipsychotic treatment; CRC cis rs9858542 0.953 rs6446272 chr3:49463287 G/A cg03060546 chr3:49711283 APEH -0.47 -6.6 -0.34 1.64e-10 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs7487075 0.820 rs7488482 chr12:46725487 C/T cg22049899 chr12:47219821 SLC38A4 0.33 6.14 0.32 2.33e-9 Itch intensity from mosquito bite; CRC cis rs3849570 0.925 rs6799080 chr3:81905591 G/A cg07356753 chr3:81810745 GBE1 -0.65 -9.51 -0.46 4.2e-19 Waist circumference;Body mass index; CRC cis rs875971 1.000 rs778710 chr7:65854834 T/C cg18876405 chr7:65276391 NA 0.52 9.04 0.45 1.37e-17 Aortic root size; CRC trans rs10435719 0.764 rs10103485 chr8:11787563 C/T cg06636001 chr8:8085503 FLJ10661 0.48 7.07 0.36 9.31e-12 C-reactive protein levels or triglyceride levels (pleiotropy); CRC cis rs4713118 0.586 rs6905522 chr6:28086479 A/C cg25164649 chr6:28176230 NA 0.77 9.5 0.46 4.6e-19 Parkinson's disease; CRC cis rs2836974 0.863 rs1065242 chr21:40567716 C/G cg17971929 chr21:40555470 PSMG1 0.83 11.94 0.55 1.5e-27 Cognitive function; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg03543731 chr15:50474621 SLC27A2 0.45 6.46 0.34 3.76e-10 Intelligence (multi-trait analysis); CRC cis rs1008375 1.000 rs4698198 chr4:17656536 G/A cg02297831 chr4:17616191 MED28 0.44 5.92 0.31 8.12e-9 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs796364 0.951 rs35618222 chr2:201065777 C/G cg12253985 chr2:200820533 C2orf60;C2orf47 0.57 6.29 0.33 9.84e-10 Schizophrenia; CRC trans rs1814175 0.647 rs4881649 chr11:49845560 A/G cg15704280 chr7:45808275 SEPT13 -0.74 -11.99 -0.55 9.71e-28 Height; CRC cis rs6076065 1.000 rs6076065 chr20:23368411 C/A cg11657817 chr20:23433608 CST11 0.36 5.63 0.3 3.78e-8 Facial morphology (factor 15, philtrum width); CRC cis rs1568889 0.838 rs1483858 chr11:28189639 A/G cg06544937 chr11:28130018 METT5D1;KIF18A 0.9 15.17 0.64 8.74e-40 Bipolar disorder; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg26768918 chr15:89010461 MRPS11;MRPL46 0.46 6.36 0.33 6.63e-10 Response to antipsychotic treatment; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg10932289 chr17:55038442 COIL 0.37 6.04 0.32 4.16e-9 Liver disease severity in Alagille syndrome; CRC cis rs7224737 1.000 rs739637 chr17:40280944 G/C cg02450064 chr17:40260053 DHX58 -0.43 -6.24 -0.33 1.38e-9 Fibrinogen levels; CRC cis rs11098499 0.645 rs72676059 chr4:120290828 C/G cg24375607 chr4:120327624 NA 0.48 7.48 0.38 6.72e-13 Corneal astigmatism; CRC cis rs7208859 0.524 rs11653605 chr17:29088385 T/G cg13385521 chr17:29058706 SUZ12P 0.73 8.33 0.42 2.14e-15 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs34172651 0.917 rs200532 chr16:24756148 C/T cg00339695 chr16:24857497 SLC5A11 -0.28 -6.78 -0.35 5.7e-11 Intelligence (multi-trait analysis); CRC cis rs17401966 0.964 rs17400510 chr1:10290421 T/C cg19773385 chr1:10388646 KIF1B -0.56 -7.86 -0.4 5.59e-14 Hepatocellular carcinoma; CRC cis rs13082711 0.911 rs13100751 chr3:27454964 A/G cg02860705 chr3:27208620 NA 0.64 8.5 0.42 6.67e-16 Systolic blood pressure;Diastolic blood pressure;Blood pressure; CRC cis rs9389248 0.690 rs2064101 chr6:135250530 G/A cg24558204 chr6:135376177 HBS1L -0.55 -8.06 -0.41 1.42e-14 High light scatter reticulocyte percentage of red cells; CRC cis rs10924970 0.967 rs6677573 chr1:235377979 T/G cg26050004 chr1:235667680 B3GALNT2 0.39 5.78 0.3 1.71e-8 Asthma; CRC cis rs11958404 0.860 rs6885815 chr5:157437253 C/T cg05962755 chr5:157440814 NA 1.01 12.88 0.58 5.12e-31 IgG glycosylation; CRC cis rs2303759 0.507 rs35042238 chr19:49872941 C/T cg22307029 chr19:49891270 CCDC155 0.67 6.64 0.34 1.27e-10 Multiple sclerosis; CRC cis rs262150 1.000 rs262150 chr7:158777934 G/A cg12590608 chr7:158785262 NA 0.45 8.1 0.41 1.08e-14 Facial morphology (factor 20); CRC cis rs9611565 0.765 rs132907 chr22:41801268 A/C cg06481639 chr22:41940642 POLR3H 0.52 5.82 0.31 1.4e-8 Vitiligo; CRC cis rs1799949 1.000 rs8176233 chr17:41219804 T/C cg19454999 chr17:41278357 BRCA1;NBR2 0.54 8.46 0.42 8.99e-16 Menopause (age at onset); CRC cis rs7618915 0.547 rs34173654 chr3:52634605 T/C cg18404041 chr3:52824283 ITIH1 -0.44 -8.95 -0.44 2.69e-17 Bipolar disorder; CRC cis rs9372498 0.536 rs62422228 chr6:118957276 T/C cg07617317 chr6:118971624 C6orf204 0.47 5.69 0.3 2.79e-8 Diastolic blood pressure; CRC cis rs11098499 0.954 rs67265404 chr4:120359270 C/T cg24375607 chr4:120327624 NA 0.51 7.89 0.4 4.55e-14 Corneal astigmatism; CRC cis rs7605827 0.930 rs6748451 chr2:15521088 A/G cg19274914 chr2:15703543 NA 0.38 5.72 0.3 2.41e-8 Educational attainment (years of education); CRC cis rs8177253 0.530 rs8177177 chr3:133463195 A/G cg24879335 chr3:133465180 TF 0.41 8.0 0.4 2.11e-14 Iron status biomarkers; CRC cis rs12451471 0.559 rs12452263 chr17:78079310 T/C cg18972013 chr17:78078605 GAA -0.39 -5.78 -0.3 1.77e-8 Plateletcrit;Mean corpuscular hemoglobin concentration; CRC cis rs798554 0.797 rs1182174 chr7:2875420 G/A cg14895029 chr7:2775587 GNA12 -0.42 -6.15 -0.32 2.23e-9 Height; CRC cis rs7224737 1.000 rs731152 chr17:40279680 G/A cg02450064 chr17:40260053 DHX58 -0.43 -6.24 -0.33 1.38e-9 Fibrinogen levels; CRC cis rs2072510 1.000 rs2072512 chr12:96408976 T/A cg22491680 chr12:96389547 HAL -0.38 -5.94 -0.31 7.3e-9 Metabolite levels (small molecules and protein measures); CRC cis rs6500395 1.000 rs3817029 chr16:48584942 C/T cg04672837 chr16:48644449 N4BP1 0.44 6.57 0.34 1.99e-10 Response to tocilizumab in rheumatoid arthritis; CRC cis rs4474465 1.000 rs7121283 chr11:78149340 T/A cg27205649 chr11:78285834 NARS2 -0.45 -5.76 -0.3 1.94e-8 Alzheimer's disease (survival time); CRC cis rs6933660 0.646 rs9383899 chr6:151781022 G/C cg14416726 chr6:151773293 C6orf211;RMND1 -0.72 -11.2 -0.53 7.09e-25 Menarche (age at onset); CRC cis rs644799 1.000 rs611020 chr11:95567905 C/T cg25622487 chr11:95524042 FAM76B;CEP57 0.76 11.8 0.55 5.02e-27 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs951366 0.617 rs708727 chr1:205767885 G/A cg14893161 chr1:205819251 PM20D1 1.04 20.0 0.74 8.28e-59 Menarche (age at onset); CRC cis rs7937682 0.883 rs484834 chr11:111465761 G/C cg19812747 chr11:111475976 SIK2 -0.57 -9.72 -0.47 8.51e-20 Primary sclerosing cholangitis; CRC trans rs11581859 0.950 rs7533945 chr1:99392575 A/G cg12183875 chr3:169587454 LRRC31 0.28 6.35 0.33 7.33e-10 Response to cognitive-behavioural therapy in anxiety disorder; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg09822051 chr1:150039084 VPS45 0.39 6.16 0.32 2.07e-9 Intelligence (multi-trait analysis); CRC cis rs13108904 0.870 rs4974578 chr4:1266072 A/G cg16405210 chr4:1374714 KIAA1530 -0.43 -5.82 -0.31 1.43e-8 Obesity-related traits; CRC cis rs425277 0.583 rs10910046 chr1:2041155 C/T cg04315214 chr1:2043799 PRKCZ 0.47 8.45 0.42 9.37e-16 Height; CRC cis rs8072100 0.905 rs8077106 chr17:45653291 T/G cg08085267 chr17:45401833 C17orf57 0.66 10.86 0.51 1.07e-23 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC trans rs2303319 0.504 rs1449641 chr2:162619567 T/C cg10272801 chr16:14013773 ERCC4 -0.68 -6.07 -0.32 3.49e-9 Cognitive function; CRC cis rs7674212 0.539 rs6815783 chr4:104122146 A/C cg16532752 chr4:104119610 CENPE -0.41 -5.78 -0.3 1.77e-8 Type 2 diabetes; CRC cis rs4665809 1.000 rs6546767 chr2:26328746 A/G cg26119090 chr2:26468346 HADHA;HADHB -0.6 -7.61 -0.39 3e-13 Gut microbiome composition (summer); CRC cis rs780096 0.506 rs56076827 chr2:27676287 A/T cg24768116 chr2:27665128 KRTCAP3 -0.35 -7.66 -0.39 2.03e-13 Total body bone mineral density; CRC cis rs12893668 0.572 rs1606 chr14:104161281 G/A cg24130564 chr14:104152367 KLC1 -0.42 -5.67 -0.3 3.2e-8 Reticulocyte count; CRC cis rs881375 1.000 rs881375 chr9:123652898 T/C cg00246817 chr9:123691163 NA -0.47 -5.97 -0.31 6.22e-9 Rheumatoid arthritis; CRC cis rs12048904 0.505 rs6577209 chr1:101255080 A/C cg00063077 chr1:101360652 SLC30A7;EXTL2 0.63 9.16 0.45 5.73e-18 Multiple sclerosis; CRC cis rs2836950 0.502 rs2150411 chr21:40574552 G/T cg17971929 chr21:40555470 PSMG1 -0.59 -8.59 -0.43 3.64e-16 Menarche (age at onset); CRC cis rs4819052 0.851 rs1056099 chr21:46678892 G/A cg02159808 chr21:46707872 POFUT2;LOC642852 0.5 6.77 0.35 5.81e-11 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs9467711 0.606 rs9379901 chr6:26603866 T/C cg16898833 chr6:26189333 HIST1H4D 0.94 7.7 0.39 1.64e-13 Autism spectrum disorder or schizophrenia; CRC cis rs7224685 0.774 rs8081417 chr17:3902650 T/A cg10724054 chr17:3904396 NA -0.41 -6.16 -0.32 2.11e-9 Type 2 diabetes; CRC cis rs72781680 1.000 rs115861480 chr2:24129464 T/A cg08917208 chr2:24149416 ATAD2B 1.01 9.97 0.48 1.29e-20 Lymphocyte counts; CRC cis rs921968 0.643 rs2556385 chr2:219532905 G/A cg02176678 chr2:219576539 TTLL4 -0.47 -7.58 -0.39 3.61e-13 Mean corpuscular hemoglobin concentration; CRC cis rs524281 0.773 rs11227413 chr11:65883696 G/A cg16950941 chr11:66035639 RAB1B -0.6 -7.45 -0.38 8.56e-13 Electroencephalogram traits; CRC cis rs853679 0.517 rs9348794 chr6:28117757 T/A cg03623178 chr6:28175578 NA 0.98 12.66 0.57 3.31e-30 Depression; CRC cis rs72615157 0.645 rs76281814 chr7:99846414 T/C cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.59 6.6 0.34 1.64e-10 Lung function (FEV1/FVC); CRC cis rs2252790 0.930 rs1204860 chr6:116588606 G/A cg18764771 chr6:116381957 FRK -0.21 -5.8 -0.3 1.53e-8 Fast beta electroencephalogram; CRC cis rs2811415 0.597 rs9839092 chr3:127742108 C/T cg13719885 chr3:127795394 NA -0.39 -5.99 -0.31 5.56e-9 Lung function (FEV1/FVC); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg15138986 chr10:131935156 GLRX3 0.39 6.31 0.33 9.07e-10 Liver disease severity in Alagille syndrome; CRC cis rs72781680 1.000 rs72796316 chr2:24132272 T/C cg08917208 chr2:24149416 ATAD2B 0.89 9.1 0.45 9.07e-18 Lymphocyte counts; CRC cis rs6502050 0.805 rs62080003 chr17:80078957 C/T cg09264619 chr17:80180166 NA 0.39 6.5 0.34 3.04e-10 Life satisfaction; CRC cis rs2991971 1.000 rs9147 chr1:46016687 T/C cg03123370 chr1:45965343 CCDC163P;MMACHC -0.39 -5.74 -0.3 2.11e-8 High light scatter reticulocyte count; CRC cis rs12142240 0.698 rs56063031 chr1:46825433 C/T cg14993813 chr1:46806288 NSUN4 -0.49 -6.22 -0.32 1.55e-9 Menopause (age at onset); CRC cis rs6496667 0.779 rs10220750 chr15:90939294 G/C cg04176472 chr15:90893244 GABARAPL3 0.56 7.35 0.38 1.62e-12 Rheumatoid arthritis; CRC cis rs7680126 0.596 rs10805364 chr4:10275518 A/G cg11266682 chr4:10021025 SLC2A9 -0.38 -6.21 -0.32 1.6e-9 Urate levels in lean individuals;Urate levels in overweight individuals;Urate levels in obese individuals; CRC trans rs2303319 0.504 rs62189053 chr2:162624324 G/A cg27342122 chr8:133787442 PHF20L1 -0.72 -6.09 -0.32 3.2e-9 Cognitive function; CRC cis rs919433 0.680 rs1961558 chr2:198487278 C/T cg10820045 chr2:198174542 NA 0.41 7.01 0.36 1.33e-11 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC cis rs7216064 0.531 rs6504573 chr17:66015963 C/T cg12091567 chr17:66097778 LOC651250 -0.69 -9.95 -0.48 1.49e-20 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CRC trans rs1814175 0.565 rs4881721 chr11:49761851 G/A cg15704280 chr7:45808275 SEPT13 -0.76 -12.55 -0.57 8.72e-30 Height; CRC cis rs372883 0.600 rs1312254 chr21:30695401 A/G cg08807101 chr21:30365312 RNF160 -0.58 -8.05 -0.41 1.55e-14 Pancreatic cancer; CRC cis rs7809950 0.953 rs2520263 chr7:107179119 T/C cg23024343 chr7:107201750 COG5 -0.62 -8.78 -0.44 9e-17 Coronary artery disease; CRC cis rs9811920 0.599 rs1688758 chr3:99539890 A/T cg07805332 chr3:99536008 MIR548G;C3orf26 0.53 8.14 0.41 8.28e-15 Axial length; CRC cis rs1046896 1.000 rs1046917 chr17:80685655 A/G cg19500275 chr17:80737654 TBCD -0.39 -5.94 -0.31 7.44e-9 Glycated hemoglobin levels; CRC cis rs7312933 0.531 rs2406674 chr12:42720150 T/C cg19980929 chr12:42632907 YAF2 -0.39 -5.9 -0.31 9.12e-9 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CRC cis rs6484504 0.576 rs158144 chr11:31211795 A/C cg14844989 chr11:31128820 NA -0.34 -6.04 -0.32 4.1e-9 Red blood cell count; CRC cis rs2573652 0.723 rs2727201 chr15:100515311 A/G cg09918751 chr15:100517450 ADAMTS17 -0.38 -5.74 -0.3 2.15e-8 Height; CRC cis rs35264875 0.950 rs35337391 chr11:68854012 A/G cg15234197 chr11:68924956 NA 0.44 6.08 0.32 3.25e-9 Blond vs. brown hair color; CRC cis rs6662572 1.000 rs55951835 chr1:46132442 T/C cg08644498 chr1:46502608 NA 0.48 7.04 0.36 1.13e-11 Blood protein levels; CRC cis rs7945705 0.870 rs1109305 chr11:8955272 C/T cg14711859 chr11:8959438 ASCL3 -0.48 -7.63 -0.39 2.6e-13 Hemoglobin concentration; CRC trans rs10982213 0.830 rs2274163 chr9:117188714 C/T ch.8.34907260F chr8:34787718 NA 0.45 6.82 0.35 4.31e-11 Interleukin-6 levels; CRC cis rs67981189 0.529 rs8010063 chr14:71510125 T/A cg15910301 chr14:71632612 NA 0.31 6.12 0.32 2.69e-9 Schizophrenia; CRC cis rs4713118 0.911 rs2394000 chr6:27686991 A/G cg15845792 chr6:28175446 NA 0.6 7.79 0.39 8.56e-14 Parkinson's disease; CRC trans rs61931739 0.517 rs11513277 chr12:34074799 G/T cg26384229 chr12:38710491 ALG10B 0.54 6.86 0.35 3.41e-11 Morning vs. evening chronotype; CRC cis rs7591163 0.959 rs10933217 chr2:228716226 T/C cg08034379 chr2:228736324 WDR69 -0.54 -7.27 -0.37 2.62e-12 Blood pressure; CRC cis rs8105895 0.935 rs28635943 chr19:22268712 G/T cg02912127 chr19:22235281 ZNF257 -0.37 -5.65 -0.3 3.53e-8 Body mass index (change over time); CRC cis rs929354 0.713 rs10085650 chr7:156993413 T/C cg17757837 chr7:157058334 UBE3C 0.74 12.57 0.57 7.46e-30 Body mass index; CRC cis rs1003719 0.591 rs2040125 chr21:38549236 C/T cg10648535 chr21:38446584 PIGP;TTC3 0.44 6.04 0.32 4.12e-9 Eye color traits; CRC cis rs2732480 0.500 rs11168468 chr12:48612465 C/T cg04545296 chr12:48745243 ZNF641 0.33 5.89 0.31 9.3e-9 Hemoglobin concentration;Red blood cell count;Hematocrit; CRC cis rs2252790 0.895 rs1204833 chr6:116572828 A/G cg18764771 chr6:116381957 FRK -0.22 -5.79 -0.3 1.62e-8 Fast beta electroencephalogram; CRC cis rs8060686 0.858 rs13334918 chr16:67901343 A/G cg19582491 chr16:67682965 RLTPR -0.39 -5.62 -0.3 4.11e-8 HDL cholesterol;Metabolic syndrome; CRC cis rs1552244 0.935 rs66493421 chr3:10092569 G/A cg00166722 chr3:10149974 C3orf24 0.68 7.96 0.4 2.81e-14 Alzheimer's disease; CRC cis rs4566357 0.615 rs2396445 chr2:227917726 C/G cg11843606 chr2:227700838 RHBDD1 -0.45 -6.83 -0.35 4.1e-11 Coronary artery disease; CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg04100724 chr12:92539208 BTG1 -0.51 -6.02 -0.31 4.54e-9 Diisocyanate-induced asthma; CRC cis rs597539 0.690 rs647661 chr11:68625875 T/C cg04772025 chr11:68637568 NA 0.53 8.26 0.41 3.71e-15 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs2243480 1.000 rs6964245 chr7:65718717 G/A cg18252515 chr7:66147081 NA 1.26 14.65 0.63 9.07e-38 Diabetic kidney disease; CRC cis rs1799949 0.894 rs36062488 chr17:41337472 C/T cg19454999 chr17:41278357 BRCA1;NBR2 -0.4 -6.27 -0.33 1.16e-9 Menopause (age at onset); CRC cis rs1552244 1.000 rs12152512 chr3:10143770 C/T cg10729496 chr3:10149963 C3orf24 0.49 6.79 0.35 5.4e-11 Alzheimer's disease; CRC cis rs60871478 0.898 rs35928069 chr7:823067 G/C cg13844804 chr7:814759 HEATR2 0.6 7.68 0.39 1.9e-13 Cerebrospinal P-tau181p levels; CRC cis rs9916302 0.904 rs11078898 chr17:37536480 A/G cg07936489 chr17:37558343 FBXL20 0.85 13.52 0.6 2.01e-33 Glomerular filtration rate (creatinine); CRC cis rs7208859 0.673 rs79541516 chr17:29240583 C/T cg13385521 chr17:29058706 SUZ12P 0.69 8.04 0.41 1.64e-14 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs6951245 1.000 rs113066613 chr7:1094128 T/C cg20603222 chr7:1096387 C7orf50;GPR146 -0.73 -8.79 -0.44 8.53e-17 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs7937682 0.737 rs663763 chr11:111422217 C/T cg09085632 chr11:111637200 PPP2R1B -0.73 -12.07 -0.55 5.16e-28 Primary sclerosing cholangitis; CRC cis rs853679 0.760 rs9295768 chr6:28209102 G/A cg06470822 chr6:28175283 NA 0.76 8.05 0.41 1.49e-14 Depression; CRC cis rs11628318 0.660 rs8009475 chr14:103058608 A/G cg23071808 chr14:103021642 NA -0.64 -7.15 -0.37 5.49e-12 Platelet count; CRC cis rs950169 0.580 rs35516100 chr15:85195430 C/T cg17507749 chr15:85114479 UBE2QP1 0.63 9.03 0.45 1.51e-17 Schizophrenia; CRC cis rs6951245 0.580 rs78894484 chr7:1138721 T/G cg26224354 chr7:1096374 C7orf50;GPR146 -0.61 -8.15 -0.41 7.88e-15 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs57221529 0.766 rs56350081 chr5:583198 G/A cg17948913 chr5:572064 NA 0.56 6.29 0.33 1e-9 Lung disease severity in cystic fibrosis; CRC cis rs9807841 0.592 rs2742313 chr19:10799750 T/C cg17710535 chr19:10819994 QTRT1 0.46 6.63 0.34 1.41e-10 Inflammatory skin disease; CRC cis rs9818758 0.556 rs13086240 chr3:49001409 G/A cg00383909 chr3:49044727 WDR6 1.31 12.49 0.57 1.46e-29 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; CRC cis rs12410462 0.892 rs75757169 chr1:227629855 A/G cg23173402 chr1:227635558 NA 0.7 7.96 0.4 2.83e-14 Major depressive disorder; CRC cis rs614226 0.872 rs12307148 chr12:120903179 T/C cg27489772 chr12:121021490 NA -0.49 -6.81 -0.35 4.62e-11 Type 1 diabetes nephropathy; CRC cis rs116095464 0.558 rs9688045 chr5:254035 T/C cg22857025 chr5:266934 NA -1.25 -16.78 -0.68 4.42e-46 Breast cancer; CRC cis rs6582630 0.519 rs4436613 chr12:38293653 T/C cg26384229 chr12:38710491 ALG10B 0.69 9.79 0.47 5.01e-20 Drug-induced liver injury (flucloxacillin); CRC cis rs13191362 1.000 rs35092540 chr6:163090778 A/G cg23758597 chr6:163146217 PARK2 -0.66 -6.64 -0.34 1.29e-10 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC trans rs1997103 0.954 rs2177807 chr7:55391002 G/T cg20935933 chr6:143382018 AIG1 -0.44 -6.38 -0.33 5.87e-10 QRS interval (sulfonylurea treatment interaction); CRC cis rs17376456 0.877 rs10476597 chr5:93367172 C/T cg25358565 chr5:93447407 FAM172A -1.0 -10.33 -0.5 7.29e-22 Diabetic retinopathy; CRC cis rs12936587 0.692 rs12943416 chr17:17535535 A/C cg24612305 chr17:17875800 TOM1L2;LRRC48 -0.44 -5.83 -0.31 1.29e-8 Hip circumference;Coronary artery disease or large artery stroke;Coronary heart disease;Coronary artery disease; CRC cis rs1862618 0.853 rs1423621 chr5:56101035 G/T cg12311346 chr5:56204834 C5orf35 -0.73 -9.42 -0.46 8.26e-19 Initial pursuit acceleration; CRC cis rs1580019 0.921 rs1580023 chr7:32497881 G/A cg07520158 chr7:32535189 LSM5;AVL9 0.45 6.48 0.34 3.4e-10 Cognitive ability; CRC cis rs4665809 1.000 rs10182857 chr2:26344411 C/T cg22920501 chr2:26401640 FAM59B -0.52 -7.15 -0.37 5.68e-12 Gut microbiome composition (summer); CRC cis rs10924970 0.687 rs3765792 chr1:235355932 A/G cg09010748 chr1:235293032 TOMM20 -0.42 -5.8 -0.3 1.53e-8 Asthma; CRC cis rs11626933 1.000 rs45463097 chr14:90744188 G/A cg14092571 chr14:90743983 NA -0.93 -14.84 -0.63 1.66e-38 Gut microbiota (bacterial taxa); CRC cis rs7098414 0.511 rs10887828 chr10:82151470 T/C cg00277334 chr10:82204260 NA -0.48 -7.74 -0.39 1.21e-13 Post bronchodilator FEV1; CRC cis rs2440129 0.632 rs2292353 chr17:6903537 C/T cg02493798 chr17:6899577 ALOX12 0.59 11.12 0.52 1.32e-24 Tonsillectomy; CRC cis rs798554 0.718 rs1636247 chr7:2881917 A/G cg17321639 chr7:2759063 NA -0.47 -6.03 -0.32 4.33e-9 Height; CRC cis rs6570726 0.738 rs4495284 chr6:145916617 T/A cg13319975 chr6:146136371 FBXO30 -0.42 -6.13 -0.32 2.48e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs17065868 0.764 rs6561177 chr13:45015539 C/T cg10246903 chr13:45222710 NA 0.57 6.3 0.33 9.58e-10 Antineutrophil cytoplasmic antibody-associated vasculitis; CRC cis rs9487023 1 rs9487023 chr6:109590004 A/G cg12927641 chr6:109611667 NA -0.33 -5.67 -0.3 3.1e-8 Red blood cell count;Mean corpuscular hemoglobin concentration;Neutrophil percentage of white cells;Lymphocyte percentage of white cells;Mean corpuscular hemoglobin;High light scatter reticulocyte percentage of red cells;Mean corpuscular volume; CRC cis rs651907 0.535 rs34063583 chr3:101509948 C/T cg12386194 chr3:101231763 SENP7 0.52 7.45 0.38 8.17e-13 Colorectal cancer; CRC cis rs1552244 1.000 rs9824585 chr3:10114802 T/C cg02579736 chr3:10068473 FANCD2;CIDECP 0.96 12.92 0.58 3.51e-31 Alzheimer's disease; CRC cis rs13108904 0.535 rs1250101 chr4:1236111 G/A cg20092199 chr4:1342459 KIAA1530 -0.38 -5.96 -0.31 6.37e-9 Obesity-related traits; CRC cis rs9522267 0.535 rs9522290 chr13:112233130 A/G cg26182253 chr13:112236782 NA 0.31 6.29 0.33 9.96e-10 Hepatitis; CRC cis rs921968 0.565 rs3821035 chr2:219620223 T/G cg02176678 chr2:219576539 TTLL4 -0.39 -6.31 -0.33 8.83e-10 Mean corpuscular hemoglobin concentration; CRC trans rs9929218 1.000 rs9282650 chr16:68809640 T/A cg04657470 chr2:198365150 HSPE1;HSPD1 -0.82 -11.54 -0.54 4.33e-26 Colorectal cancer; CRC cis rs6088580 0.634 rs62212172 chr20:32987705 G/A cg08999081 chr20:33150536 PIGU -0.62 -11.47 -0.53 7.71e-26 Glomerular filtration rate (creatinine); CRC cis rs9517320 0.534 rs4771306 chr13:99143661 T/C cg07423050 chr13:99094983 FARP1 -0.57 -8.14 -0.41 8.31e-15 Longevity; CRC cis rs8044995 0.706 rs73612697 chr16:68162016 G/A cg26727032 chr16:67993705 SLC12A4 -0.56 -6.31 -0.33 9.02e-10 Schizophrenia; CRC cis rs13118159 0.872 rs4974604 chr4:1345798 T/C cg20092199 chr4:1342459 KIAA1530 0.33 5.81 0.3 1.5e-8 Longevity; CRC trans rs11231420 1 rs11231420 chr11:55644734 T/C cg27395922 chr11:50257633 LOC441601 0.41 6.68 0.35 1.04e-10 Pelvic organ prolapse (moderate/severe); CRC cis rs6952808 0.964 rs6945719 chr7:1932688 G/A cg20295408 chr7:1910781 MAD1L1 -0.44 -6.1 -0.32 3.01e-9 Bipolar disorder and schizophrenia; CRC cis rs8180040 0.966 rs13064843 chr3:47415467 C/T cg10298567 chr3:47292165 KIF9 -0.36 -5.91 -0.31 8.43e-9 Colorectal cancer; CRC cis rs4423214 1.000 rs1044482 chr11:71155171 C/T cg05163923 chr11:71159392 DHCR7 0.65 9.63 0.47 1.73e-19 Vitamin D levels; CRC cis rs751728 1.000 rs3793079 chr6:33767788 T/A cg25922239 chr6:33757077 LEMD2 0.61 9.32 0.46 1.68e-18 Crohn's disease; CRC cis rs2153535 0.580 rs7761937 chr6:8459434 A/T cg07606381 chr6:8435919 SLC35B3 0.68 11.04 0.52 2.55e-24 Motion sickness; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg18854735 chr1:1822972 GNB1 0.5 6.64 0.34 1.34e-10 Thyroid stimulating hormone; CRC cis rs185694 1.000 rs185694 chr13:30885223 C/T cg04551440 chr13:30881194 KATNAL1 0.57 6.21 0.32 1.61e-9 Antineutrophil cytoplasmic antibody-associated vasculitis; CRC trans rs6550704 0.687 rs9865314 chr3:22634337 A/G cg08617916 chr1:206730453 RASSF5 -0.4 -5.98 -0.31 5.85e-9 Daytime sleep phenotypes; CRC cis rs4713118 0.824 rs13211701 chr6:27750079 T/C cg19041857 chr6:27730383 NA -0.44 -5.94 -0.31 7.12e-9 Parkinson's disease; CRC cis rs875971 0.545 rs7787063 chr7:65628999 G/A cg03233332 chr7:66118400 NA -0.45 -6.28 -0.33 1.1e-9 Aortic root size; CRC cis rs28386778 0.897 rs2854221 chr17:61941445 G/T cg11494091 chr17:61959527 GH2 0.59 9.95 0.48 1.45e-20 Prudent dietary pattern; CRC cis rs6938 0.534 rs7495739 chr15:75185670 C/T cg09165964 chr15:75287851 SCAMP5 -0.55 -8.64 -0.43 2.4e-16 Breast cancer; CRC cis rs6840360 0.642 rs11932398 chr4:152397554 T/G cg09659197 chr4:152720779 NA 0.34 6.64 0.34 1.32e-10 Intelligence (multi-trait analysis); CRC cis rs2041840 0.538 rs10196818 chr2:37576852 A/G cg25727520 chr2:37576821 QPCT -0.35 -6.25 -0.33 1.29e-9 Chronic lymphocytic leukemia; CRC cis rs9556958 0.527 rs9517313 chr13:99105892 C/G cg20487152 chr13:99095054 FARP1 0.47 7.28 0.37 2.45e-12 Educational attainment (years of education); CRC cis rs6460942 0.915 rs62448602 chr7:12457145 T/G cg06484146 chr7:12443880 VWDE -0.77 -8.08 -0.41 1.26e-14 Coronary artery disease; CRC cis rs950169 0.810 rs62029594 chr15:84955252 T/C cg17507749 chr15:85114479 UBE2QP1 0.74 10.59 0.5 9.91e-23 Schizophrenia; CRC cis rs477895 0.653 rs11602181 chr11:63896591 C/G cg18225595 chr11:63971243 STIP1 0.55 7.26 0.37 2.85e-12 Mean platelet volume; CRC cis rs853679 0.517 rs9380058 chr6:28127444 T/C cg12963246 chr6:28129442 ZNF389 0.5 5.75 0.3 2e-8 Depression; CRC cis rs2050392 0.799 rs2907 chr10:30728250 A/G cg18806716 chr10:30721971 MAP3K8 -0.5 -7.62 -0.39 2.65e-13 Inflammatory bowel disease; CRC cis rs2228479 0.867 rs57940434 chr16:89975496 G/A cg06558623 chr16:89946397 TCF25 0.89 9.76 0.47 6.25e-20 Skin colour saturation; CRC cis rs1832871 0.711 rs56043101 chr6:158682277 A/G cg07165851 chr6:158734300 TULP4 0.61 7.75 0.39 1.18e-13 Height; CRC cis rs4713118 0.513 rs149955 chr6:28036225 G/C cg20615401 chr6:28092323 ZSCAN16 0.46 6.04 0.32 4.22e-9 Parkinson's disease; CRC cis rs9467711 0.651 rs72832596 chr6:25962951 C/A cg12315302 chr6:26189340 HIST1H4D 0.72 6.03 0.32 4.44e-9 Autism spectrum disorder or schizophrenia; CRC cis rs507506 0.771 rs929229 chr17:7105399 C/T cg25256661 chr17:7137939 DVL2 0.73 12.47 0.57 1.65e-29 Adiponectin levels; CRC cis rs896854 0.967 rs896853 chr8:95960855 G/C cg16049864 chr8:95962084 TP53INP1 -0.68 -12.61 -0.57 5.34e-30 Type 2 diabetes; CRC cis rs3806843 1.000 rs2240694 chr5:140183058 G/A cg16607685 chr5:140181889 PCDHA2;PCDHA1;PCDHA3 -0.26 -5.97 -0.31 6.03e-9 Depressive symptoms (multi-trait analysis); CRC cis rs875971 0.660 rs3857686 chr7:66036191 C/T cg11764359 chr7:65958608 NA -0.55 -8.63 -0.43 2.66e-16 Aortic root size; CRC cis rs6570726 0.846 rs973856 chr6:145781916 C/T cg05347473 chr6:146136440 FBXO30 -0.35 -5.66 -0.3 3.38e-8 Lobe attachment (rater-scored or self-reported); CRC cis rs909674 0.541 rs5757655 chr22:39797178 C/G cg11247378 chr22:39784982 NA 0.49 9.78 0.47 5.56e-20 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg10210959 chr5:112257975 REEP5 0.44 6.06 0.32 3.75e-9 Anxiety disorder; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg03771385 chr2:43454876 ZFP36L2;LOC100129726 -0.45 -6.74 -0.35 7.1e-11 Myopia (pathological); CRC cis rs9517313 0.592 rs61969458 chr13:99177633 A/G cg07423050 chr13:99094983 FARP1 -0.55 -7.77 -0.39 1.02e-13 Neuroticism; CRC cis rs6120849 0.754 rs36003887 chr20:33589107 G/A cg08999081 chr20:33150536 PIGU 0.46 5.88 0.31 9.91e-9 Protein C levels; CRC cis rs9399135 0.967 rs7741515 chr6:135374368 C/G cg24558204 chr6:135376177 HBS1L -0.49 -7.77 -0.39 1.02e-13 Red blood cell count; CRC trans rs6703335 0.870 rs10803142 chr1:243598234 A/G cg14229668 chr2:163200576 GCA 0.44 6.1 0.32 3.02e-9 Schizophrenia;Schizophrenia, schizoaffective disorder or bipolar disorder; CRC cis rs6912958 0.559 rs369674 chr6:88043402 C/G cg12350822 chr6:88032061 C6orf162;GJB7 -0.47 -9.56 -0.47 2.78e-19 Monocyte percentage of white cells; CRC cis rs250677 0.687 rs40522 chr5:148442295 G/A cg18129178 chr5:148520854 ABLIM3 -0.36 -5.7 -0.3 2.62e-8 Breast cancer; CRC cis rs6938 0.534 rs12904897 chr15:75217686 A/G cg17294928 chr15:75287854 SCAMP5 0.51 7.87 0.4 5.18e-14 Breast cancer; CRC cis rs17270561 0.609 rs1165181 chr6:25825390 T/A cg16482183 chr6:26056742 HIST1H1C 0.54 7.47 0.38 7.46e-13 Iron status biomarkers; CRC cis rs8018967 0.622 rs2041073 chr14:73972535 C/T cg19682024 chr14:74008259 HEATR4;ACOT1 0.57 8.66 0.43 2.13e-16 Blood metabolite ratios; CRC cis rs7666738 0.830 rs9307218 chr4:99024885 T/C cg17366294 chr4:99064904 C4orf37 0.43 7.13 0.37 6.27e-12 Colonoscopy-negative controls vs population controls; CRC cis rs6062302 0.522 rs3761126 chr20:62252044 C/T cg16989086 chr20:62203971 PRIC285 0.5 6.32 0.33 8.41e-10 Glioblastoma; CRC cis rs514406 0.679 rs541852 chr1:53256834 A/G cg25767906 chr1:53392781 SCP2 0.52 8.1 0.41 1.05e-14 Monocyte count; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg05397629 chr11:3848986 RHOG -0.38 -6.08 -0.32 3.32e-9 Liver disease severity in Alagille syndrome; CRC cis rs6163 0.727 rs284862 chr10:104572081 C/T cg11453585 chr10:104263688 ACTR1A;SUFU 0.46 6.62 0.34 1.51e-10 Waist circumference;Hip circumference; CRC cis rs6500602 0.701 rs1362626 chr16:4549226 C/G cg06139259 chr16:4526053 HMOX2;NMRAL1 0.43 6.09 0.32 3.21e-9 Schizophrenia; CRC cis rs561341 1.000 rs55978022 chr17:30275937 T/C cg12193833 chr17:30244370 NA -0.75 -8.72 -0.43 1.4e-16 Hip circumference adjusted for BMI; CRC cis rs2295359 0.892 rs12401432 chr1:67656931 C/G cg17031739 chr1:67600172 NA 0.4 6.32 0.33 8.6e-10 Psoriasis; CRC cis rs4689592 0.503 rs59640165 chr4:7051661 G/A cg06697600 chr4:7070879 GRPEL1 0.52 6.59 0.34 1.76e-10 Monocyte percentage of white cells; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg26276294 chr10:30024803 SVIL 0.44 6.01 0.31 5.04e-9 Anxiety disorder; CRC trans rs2727020 0.894 rs1917328 chr11:49359606 G/A cg03929089 chr4:120376271 NA -0.71 -9.31 -0.46 1.91e-18 Coronary artery disease; CRC cis rs9463078 0.774 rs9381383 chr6:45271893 G/A cg25276700 chr6:44698697 NA -0.28 -6.73 -0.35 7.77e-11 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; CRC cis rs3126085 0.935 rs1390488 chr1:152199500 T/C cg09127314 chr1:152161683 NA 0.47 6.02 0.31 4.67e-9 Atopic dermatitis; CRC cis rs9291683 0.507 rs6849273 chr4:10021595 C/T cg11266682 chr4:10021025 SLC2A9 0.53 10.89 0.51 8.91e-24 Bone mineral density; CRC cis rs6840360 0.642 rs6843639 chr4:152416015 C/T cg09659197 chr4:152720779 NA 0.33 6.52 0.34 2.64e-10 Intelligence (multi-trait analysis); CRC cis rs9903692 0.954 rs2051821 chr17:46143515 T/C cg21215337 chr17:46176117 CBX1 0.42 7.71 0.39 1.47e-13 Pulse pressure; CRC cis rs8126001 0.573 rs7271530 chr20:62727915 A/G cg03642690 chr20:62727907 OPRL1 0.36 5.8 0.3 1.53e-8 Pulse pressure;Mean corpuscular volume; CRC cis rs7534824 0.543 rs72734256 chr1:101390090 T/C cg16556008 chr1:101360663 SLC30A7;EXTL2 0.61 6.32 0.33 8.53e-10 Refractive astigmatism; CRC cis rs6754311 0.773 rs680428 chr2:136630757 A/G cg25344623 chr2:136566232 LCT 0.33 6.03 0.32 4.33e-9 Mosquito bite size; CRC cis rs3857067 0.806 rs34396894 chr4:95097600 T/G cg11021082 chr4:95130006 SMARCAD1 -0.5 -7.74 -0.39 1.21e-13 QT interval; CRC cis rs6089584 0.888 rs6089623 chr20:60615759 A/G cg18761221 chr20:60518478 NA 0.46 7.32 0.37 1.89e-12 Body mass index; CRC cis rs7584330 0.554 rs7573177 chr2:238444467 C/T cg14458575 chr2:238380390 NA -0.53 -7.48 -0.38 6.89e-13 Prostate cancer; CRC cis rs6062302 0.522 rs11696202 chr20:62246292 G/C cg06363034 chr20:62225388 GMEB2 -0.44 -6.8 -0.35 4.95e-11 Glioblastoma; CRC cis rs116095464 0.558 rs7725227 chr5:233517 G/A cg22496380 chr5:211416 CCDC127 -0.9 -10.32 -0.49 8.19e-22 Breast cancer; CRC trans rs7615952 0.673 rs3811677 chr3:125648080 G/A cg00769240 chr8:12517080 NA -0.54 -6.7 -0.35 9.27e-11 Blood pressure (smoking interaction); CRC cis rs10256972 0.552 rs7805591 chr7:1210745 A/G cg27094323 chr7:1216898 NA -0.37 -6.01 -0.31 5.01e-9 Longevity;Endometriosis; CRC cis rs4926298 1.000 rs1077151 chr19:13151108 A/G cg04657146 chr19:12876947 HOOK2 -0.46 -6.17 -0.32 1.96e-9 Bipolar disorder; CRC cis rs4665809 0.549 rs3828255 chr2:26413252 G/A cg08067268 chr2:26466485 HADHB;HADHA 0.64 7.36 0.38 1.46e-12 Gut microbiome composition (summer); CRC cis rs1448094 0.549 rs4919770 chr12:86238050 G/T cg25456477 chr12:86230367 RASSF9 0.34 6.08 0.32 3.29e-9 Major depressive disorder; CRC cis rs2243480 0.764 rs2460423 chr7:65601216 A/T cg18252515 chr7:66147081 NA -1.25 -14.8 -0.63 2.45e-38 Diabetic kidney disease; CRC cis rs6960043 0.875 rs2215382 chr7:15055010 C/G cg19272540 chr7:15055459 NA 0.24 6.71 0.35 8.52e-11 Type 2 diabetes; CRC trans rs11654801 0.812 rs11658742 chr17:20851512 G/C cg23759823 chr7:139672531 TBXAS1 -0.39 -6.18 -0.32 1.89e-9 Mosquito bite size; CRC trans rs944990 0.595 rs10123378 chr9:96375217 C/T cg08187779 chr8:102217898 ZNF706 0.41 6.51 0.34 2.74e-10 Body mass index; CRC cis rs2576037 0.542 rs4630643 chr18:44508142 G/A cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.63 10.18 0.49 2.48e-21 Personality dimensions; CRC cis rs7647973 1.000 rs13096474 chr3:49443081 C/T cg07690219 chr3:49449608 TCTA;RHOA 0.51 6.0 0.31 5.21e-9 Menarche (age at onset); CRC cis rs12980942 0.630 rs11881940 chr19:41808432 A/T cg25627403 chr19:41769009 HNRNPUL1 0.52 6.02 0.31 4.73e-9 Coronary artery disease; CRC cis rs9381040 1.000 rs2093396 chr6:41155000 G/A cg03644281 chr6:41068752 NFYA;LOC221442 -0.47 -6.41 -0.33 5.06e-10 Alzheimer's disease (late onset); CRC cis rs754466 0.580 rs11002294 chr10:79540588 T/C cg17075019 chr10:79541650 NA -0.97 -18.55 -0.72 4.41e-53 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs6066835 1.000 rs4431002 chr20:47316585 C/T cg18078177 chr20:47281410 PREX1 0.66 5.68 0.3 2.92e-8 Multiple myeloma; CRC cis rs12188164 1.000 rs56042615 chr5:437667 G/A cg17553881 chr5:443987 EXOC3;C5orf55 -0.36 -7.56 -0.38 4.07e-13 Cystic fibrosis severity; CRC cis rs17152411 0.947 rs17152408 chr10:126649007 C/T cg07906193 chr10:126599966 NA 0.59 6.68 0.35 1.02e-10 Height; CRC cis rs6938 0.514 rs56338926 chr15:75259335 C/A cg05627522 chr15:75251581 NA 0.5 7.55 0.38 4.22e-13 Breast cancer; CRC cis rs7568458 0.684 rs3731828 chr2:85806266 C/T cg02493740 chr2:85810744 VAMP5 -0.54 -8.2 -0.41 5.3e-15 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); CRC trans rs10506458 0.834 rs17738403 chr12:63389200 A/G cg03429785 chr15:59498649 MYO1E;LDHAL6B -1.46 -21.13 -0.76 3.29e-63 Hemostatic factors and hematological phenotypes; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg10324419 chr4:175205038 FBXO8;KIAA1712 0.47 6.13 0.32 2.5e-9 Thyroid stimulating hormone; CRC cis rs1129187 0.818 rs9462858 chr6:42946490 C/A cg09436375 chr6:42928200 GNMT -0.32 -5.73 -0.3 2.21e-8 Alzheimer's disease in APOE e4+ carriers; CRC cis rs7312933 1.000 rs3229 chr12:42475888 G/A cg01256987 chr12:42539512 GXYLT1 -0.43 -6.51 -0.34 2.83e-10 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CRC cis rs4901869 1.000 rs4901869 chr14:59334128 A/G cg02291164 chr14:59296302 NA 0.34 6.26 0.33 1.21e-9 Panic disorder; CRC cis rs172166 0.637 rs1233708 chr6:28173219 C/T cg06470822 chr6:28175283 NA 0.79 11.91 0.55 2.02e-27 Cardiac Troponin-T levels; CRC cis rs652260 0.663 rs580984 chr19:7881030 C/T cg26014689 chr19:7917955 EVI5L -0.42 -6.47 -0.34 3.55e-10 Menarche (age at onset); CRC cis rs1023500 0.573 rs1807494 chr22:42474138 C/G cg25452165 chr22:42524984 CYP2D6 -0.4 -6.05 -0.32 3.94e-9 Schizophrenia; CRC cis rs2404602 0.716 rs7169394 chr15:76913274 G/A cg03037974 chr15:76606532 NA 0.69 12.16 0.56 2.4e-28 Blood metabolite levels; CRC cis rs2976388 0.578 rs3736010 chr8:143817503 T/C cg12516270 chr8:143859308 LYNX1 -0.41 -6.38 -0.33 5.92e-10 Urinary tract infection frequency; CRC cis rs9322193 0.886 rs9767555 chr6:149968158 T/C cg07701084 chr6:150067640 NUP43 0.58 8.04 0.41 1.61e-14 Lung cancer; CRC cis rs9896052 0.580 rs8065142 chr17:73441060 G/A cg21038819 chr17:73507788 CASKIN2 0.42 5.84 0.31 1.26e-8 Sight-threatening diabetic retinopathy in type 2 diabetes; CRC cis rs908922 0.676 rs1053590 chr1:152488428 T/C cg09873164 chr1:152488093 CRCT1 0.37 6.18 0.32 1.9e-9 Hair morphology; CRC cis rs7216064 0.684 rs8182243 chr17:66018505 T/C cg12091567 chr17:66097778 LOC651250 0.92 13.92 0.61 5.72e-35 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CRC trans rs7618501 0.966 rs7372966 chr3:49788969 T/C cg21665057 chr3:196295764 WDR53;FBXO45 -0.87 -15.74 -0.66 5.06e-42 Intelligence (multi-trait analysis); CRC cis rs17234274 0.622 rs10833980 chr11:23232587 A/G cg05245346 chr11:23248277 NA 0.36 5.84 0.31 1.23e-8 Cancer; CRC cis rs9322193 0.884 rs11155689 chr6:150129606 T/C cg13206674 chr6:150067644 NUP43 0.57 8.16 0.41 6.99e-15 Lung cancer; CRC cis rs9796 0.870 rs7162992 chr15:41290861 T/C cg18705301 chr15:41695430 NDUFAF1 -0.36 -6.18 -0.32 1.9e-9 Menopause (age at onset); CRC cis rs4888262 0.545 rs4888270 chr16:74698576 A/G cg01733217 chr16:74700730 RFWD3 0.81 12.57 0.57 7.2e-30 Testicular germ cell tumor; CRC trans rs10858396 0.957 rs7029858 chr9:138273821 C/T cg07360250 chr5:176830358 F12 0.45 6.0 0.31 5.16e-9 Attention deficit hyperactivity disorder; CRC trans rs8073060 0.586 rs225280 chr17:33976296 C/T cg19694781 chr19:47549865 TMEM160 -1.05 -14.75 -0.63 3.75e-38 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; CRC trans rs1346081 0.786 rs1425645 chr4:68028175 C/T cg11117577 chr8:125551212 TATDN1;NDUFB9 0.5 6.08 0.32 3.37e-9 Intelligence (multi-trait analysis); CRC trans rs561341 1.000 rs55978022 chr17:30275937 T/C cg20587970 chr11:113659929 NA -1.42 -20.2 -0.74 1.43e-59 Hip circumference adjusted for BMI; CRC cis rs2354432 0.891 rs2165743 chr1:146690319 C/T cg25205988 chr1:146714368 CHD1L 1.15 12.62 0.57 4.76e-30 Mitochondrial DNA levels; CRC cis rs8180040 0.966 rs2101247 chr3:47494303 G/A cg27129171 chr3:47204927 SETD2 -0.6 -9.36 -0.46 1.24e-18 Colorectal cancer; CRC cis rs9611565 0.559 rs7290990 chr22:41964357 C/A cg06634786 chr22:41940651 POLR3H -0.51 -5.92 -0.31 8.16e-9 Vitiligo; CRC trans rs208520 1.000 rs9453671 chr6:66991208 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.89 10.8 0.51 1.77e-23 Exhaled nitric oxide output; CRC cis rs7208859 0.673 rs73277986 chr17:29196197 C/T cg13385521 chr17:29058706 SUZ12P 0.65 7.71 0.39 1.51e-13 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs17376456 0.877 rs66696214 chr5:93424533 G/A cg21475434 chr5:93447410 FAM172A 0.75 7.65 0.39 2.18e-13 Diabetic retinopathy; CRC trans rs13086611 1 rs13086611 chr3:49385417 A/T cg21582582 chr3:182698605 DCUN1D1 -0.53 -6.83 -0.35 4.15e-11 Educational attainment; CRC cis rs11098499 0.863 rs3822191 chr4:120428101 A/T cg24375607 chr4:120327624 NA 0.46 6.98 0.36 1.63e-11 Corneal astigmatism; CRC cis rs17376456 0.825 rs7715562 chr5:93222034 C/T cg09848695 chr5:92956644 FAM172A;MIR2277 -0.65 -5.89 -0.31 9.42e-9 Diabetic retinopathy; CRC cis rs6747952 0.866 rs4663854 chr2:239083167 C/T cg17459225 chr2:239074497 NA -0.45 -7.82 -0.4 7.15e-14 Mean corpuscular hemoglobin concentration; CRC trans rs877282 1.000 rs12773872 chr10:771939 T/C cg22713356 chr15:30763199 NA 1.27 15.87 0.66 1.59e-42 Uric acid levels; CRC cis rs787274 0.850 rs7873289 chr9:115638386 G/A cg13803584 chr9:115635662 SNX30 -0.65 -5.96 -0.31 6.41e-9 Age-related hearing impairment (SNP x SNP interaction); CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg09455096 chr2:61765470 XPO1 -0.52 -6.27 -0.33 1.15e-9 Diisocyanate-induced asthma; CRC cis rs8005677 0.798 rs61977741 chr14:23400979 G/C cg25600027 chr14:23388339 RBM23 -0.44 -6.58 -0.34 1.81e-10 Cognitive ability (multi-trait analysis); CRC cis rs561341 1.000 rs542132 chr17:30307193 A/T cg19193384 chr17:30244184 NA -0.65 -7.49 -0.38 6.26e-13 Hip circumference adjusted for BMI; CRC cis rs8044868 0.530 rs2288002 chr16:72057282 A/G cg23815491 chr16:72088622 HP 0.47 6.84 0.35 3.85e-11 Body mass index (change over time) in cancer or chronic obstructive pulmonary disease;Body mass index (change over time) in cancer; CRC cis rs311392 1.000 rs413974 chr8:55088510 A/G cg20636351 chr8:55087400 NA -0.33 -5.85 -0.31 1.22e-8 Pelvic organ prolapse (moderate/severe); CRC cis rs4713118 0.513 rs9368547 chr6:28028067 A/G cg23161317 chr6:28129485 ZNF389 0.45 6.32 0.33 8.37e-10 Parkinson's disease; CRC cis rs4727027 0.933 rs6464940 chr7:148826309 G/T cg23583168 chr7:148888333 NA -0.89 -15.24 -0.64 4.88e-40 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC cis rs8141529 0.748 rs132531 chr22:29297365 C/T cg15103426 chr22:29168792 CCDC117 -0.5 -6.96 -0.36 1.88e-11 Lymphocyte counts; CRC cis rs1448094 0.802 rs11513957 chr12:86435551 C/T cg18827107 chr12:86230957 RASSF9 -0.37 -5.74 -0.3 2.13e-8 Major depressive disorder; CRC cis rs2239547 0.522 rs6771610 chr3:53026104 T/C cg05573699 chr3:52720067 GNL3;PBRM1 -0.43 -5.75 -0.3 2.02e-8 Schizophrenia; CRC cis rs881375 0.678 rs4836834 chr9:123665901 T/A cg14255062 chr9:123606675 PSMD5;LOC253039 0.4 6.3 0.33 9.81e-10 Rheumatoid arthritis; CRC cis rs2032447 0.714 rs199734 chr6:25940393 G/C cg04800585 chr6:26043546 HIST1H2BB 0.5 7.16 0.37 5.27e-12 Intelligence (multi-trait analysis); CRC cis rs11148252 0.840 rs56304200 chr13:52781763 T/A cg02158880 chr13:53174818 NA 0.46 6.87 0.35 3.31e-11 Lewy body disease; CRC cis rs2153535 0.562 rs10458225 chr6:8386004 G/A cg07606381 chr6:8435919 SLC35B3 -0.66 -10.52 -0.5 1.71e-22 Motion sickness; CRC cis rs1619661 0.505 rs10793525 chr10:44683833 C/A cg09554077 chr10:44749378 NA 0.47 7.14 0.37 6.09e-12 QT interval (ambient particulate matter interaction); CRC cis rs6988636 1.000 rs7002332 chr8:124185442 G/C cg27053337 chr8:124217698 FAM83A 0.45 6.84 0.35 3.77e-11 Urinary uromodulin levels; CRC trans rs3942852 0.712 rs2174129 chr11:48108557 A/C cg03929089 chr4:120376271 NA -0.54 -6.82 -0.35 4.4e-11 Acute lymphoblastic leukemia (childhood); CRC cis rs6942756 0.806 rs9641846 chr7:128873679 G/A cg02491457 chr7:128862824 NA 0.64 9.03 0.45 1.44e-17 White matter hyperintensity burden; CRC cis rs9858542 0.953 rs11926781 chr3:49603289 C/T cg07274523 chr3:49395745 GPX1 0.48 6.38 0.33 5.98e-10 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC trans rs208520 0.690 rs12202805 chr6:66703903 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.0 -14.04 -0.61 2.03e-35 Exhaled nitric oxide output; CRC cis rs12142240 0.698 rs56344958 chr1:46814518 G/A cg14993813 chr1:46806288 NSUN4 -0.5 -6.4 -0.33 5.38e-10 Menopause (age at onset); CRC cis rs2404602 0.716 rs17460201 chr15:76673627 C/T cg03037974 chr15:76606532 NA -0.7 -12.13 -0.56 3.07e-28 Blood metabolite levels; CRC cis rs644799 0.930 rs587123 chr11:95560539 T/G cg03916912 chr11:95522834 CEP57;FAM76B 0.95 18.38 0.71 2.03e-52 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs17401966 0.540 rs58014725 chr1:10474457 T/A cg19773385 chr1:10388646 KIF1B -0.48 -7.45 -0.38 8.24e-13 Hepatocellular carcinoma; CRC cis rs2949837 0.581 rs2965072 chr7:45980751 G/T cg23193639 chr7:45961078 IGFBP3 0.41 6.84 0.35 3.79e-11 Sitting height ratio; CRC cis rs6662572 1.000 rs6662572 chr1:46146812 A/G cg03123370 chr1:45965343 CCDC163P;MMACHC 0.49 5.86 0.31 1.12e-8 Blood protein levels; CRC cis rs10256972 0.933 rs35696159 chr7:1047194 A/G cg07308232 chr7:1071921 C7orf50 -0.42 -5.73 -0.3 2.27e-8 Longevity;Endometriosis; CRC trans rs6550704 0.687 rs9865314 chr3:22634337 A/G cg26872475 chr11:119039430 NLRX1 -0.44 -6.61 -0.34 1.59e-10 Daytime sleep phenotypes; CRC trans rs9747201 0.962 rs62079995 chr17:80076624 C/T cg07393940 chr7:158741817 NA -0.5 -7.2 -0.37 4.24e-12 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs10504229 0.593 rs12216730 chr8:58003894 C/T cg02725872 chr8:58115012 NA -0.43 -6.55 -0.34 2.2e-10 Developmental language disorder (linguistic errors); CRC cis rs9534288 0.659 rs7996394 chr13:46653503 A/C cg15192986 chr13:46630673 CPB2 -0.68 -8.81 -0.44 7.51e-17 Blood protein levels; CRC cis rs9611519 0.780 rs3171692 chr22:41642212 C/T cg03806693 chr22:41940476 POLR3H -0.74 -10.21 -0.49 1.95e-21 Neuroticism; CRC cis rs853679 0.517 rs9393886 chr6:28050039 T/G cg12273811 chr6:28175739 NA 0.71 9.2 0.45 4.28e-18 Depression; CRC cis rs950880 0.560 rs1558619 chr2:102931550 G/T cg09003973 chr2:102972529 NA -0.38 -5.66 -0.3 3.29e-8 Serum protein levels (sST2); CRC cis rs4363385 0.655 rs11205163 chr1:152983677 C/T cg25856811 chr1:152973957 SPRR3 -0.26 -6.96 -0.36 1.88e-11 Inflammatory skin disease; CRC trans rs3733585 0.673 rs6843873 chr4:9958788 A/C cg26043149 chr18:55253948 FECH -0.49 -7.52 -0.38 5.15e-13 Cleft plate (environmental tobacco smoke interaction); CRC cis rs9462027 0.606 rs412392 chr6:34549699 A/G cg07306190 chr6:34760872 UHRF1BP1 -0.34 -5.94 -0.31 7.35e-9 Systemic lupus erythematosus; CRC cis rs2991971 0.934 rs7903 chr1:45976472 G/C cg15605315 chr1:45957053 TESK2 0.42 6.8 0.35 4.86e-11 High light scatter reticulocyte count; CRC cis rs10504229 0.728 rs17804624 chr8:58154216 T/C cg22535103 chr8:58192502 C8orf71 -0.68 -8.37 -0.42 1.72e-15 Developmental language disorder (linguistic errors); CRC cis rs6933660 0.646 rs3736176 chr6:151773320 T/A cg10883421 chr6:151773342 RMND1;C6orf211 0.8 14.58 0.63 1.69e-37 Menarche (age at onset); CRC cis rs35306767 0.903 rs12769431 chr10:922633 T/C cg20503657 chr10:835505 NA 0.94 11.83 0.55 3.85e-27 Eosinophil percentage of granulocytes; CRC cis rs2576037 0.526 rs10853544 chr18:44474194 T/C cg24750912 chr18:44543259 TCEB3CL;KATNAL2 0.28 5.65 0.3 3.45e-8 Personality dimensions; CRC cis rs9287719 0.601 rs62128635 chr2:10725334 G/C cg00105475 chr2:10696890 NA 0.47 7.05 0.36 1.06e-11 Prostate cancer; CRC trans rs2228479 0.850 rs2190808 chr16:89840856 C/T cg21302420 chr1:112162376 RAP1A 0.72 5.96 0.31 6.33e-9 Skin colour saturation; CRC trans rs10982213 0.830 rs2274163 chr9:117188714 C/T cg26483432 chr1:149815043 HIST2H2AA3;HIST2H2AA4 0.44 6.48 0.34 3.42e-10 Interleukin-6 levels; CRC cis rs10191773 0.535 rs11123133 chr2:112965023 G/A cg04979063 chr2:113191202 RGPD5;RGPD8 0.6 5.64 0.3 3.71e-8 Yeast infection; CRC cis rs7666738 0.791 rs6532725 chr4:99061479 T/C cg05340658 chr4:99064831 C4orf37 0.61 9.47 0.46 5.5e-19 Colonoscopy-negative controls vs population controls; CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg25219047 chr19:3500813 DOHH -0.55 -6.69 -0.35 9.85e-11 Diisocyanate-induced asthma; CRC cis rs875971 0.862 rs778707 chr7:65857027 G/A cg11764359 chr7:65958608 NA 0.57 8.44 0.42 1.01e-15 Aortic root size; CRC trans rs8002861 0.641 rs6561148 chr13:44426269 C/T cg17145862 chr1:211918768 LPGAT1 0.56 9.56 0.47 2.82e-19 Leprosy; CRC cis rs13191362 0.935 rs34268859 chr6:162934731 G/A cg21926612 chr6:163149169 PACRG;PARK2 0.79 9.53 0.46 3.7e-19 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs13108904 0.557 rs1680033 chr4:1243404 C/T cg19318889 chr4:1322082 MAEA -0.65 -9.32 -0.46 1.7e-18 Obesity-related traits; CRC trans rs3794271 0.706 rs9971816 chr12:20826911 C/T cg19856771 chr13:42780042 DGKH 0.41 6.01 0.31 4.89e-9 Response to TNF-alpha inhibitors in rheumatoid arthritis; CRC cis rs10504229 0.683 rs7817188 chr8:58129549 C/T cg22535103 chr8:58192502 C8orf71 -0.7 -9.34 -0.46 1.47e-18 Developmental language disorder (linguistic errors); CRC cis rs17095355 1.000 rs72828241 chr10:111744704 T/A cg00817464 chr10:111662876 XPNPEP1 -0.59 -6.98 -0.36 1.59e-11 Biliary atresia; CRC cis rs7692995 1.000 rs16896271 chr4:18012454 T/C cg08925142 chr4:18023851 LCORL -0.53 -5.89 -0.31 9.52e-9 Height; CRC cis rs394563 0.589 rs1900300 chr6:149641627 T/C cg03678062 chr6:149772716 ZC3H12D 0.33 5.91 0.31 8.54e-9 Dupuytren's disease; CRC cis rs477692 0.905 rs544217 chr10:131420584 A/G cg05714579 chr10:131428358 MGMT 0.59 8.44 0.42 1.02e-15 Response to temozolomide; CRC cis rs7119 0.689 rs11630557 chr15:77820712 A/G cg10437265 chr15:77819839 NA 0.67 12.49 0.57 1.39e-29 Type 2 diabetes; CRC cis rs13315871 0.929 rs1047335 chr3:58280942 A/G cg20936604 chr3:58311152 NA -0.63 -6.27 -0.33 1.12e-9 Cholesterol, total; CRC cis rs3858526 0.584 rs10742809 chr11:5862532 G/T cg02574844 chr11:5959923 NA 0.47 6.93 0.36 2.29e-11 DNA methylation (variation); CRC cis rs12893668 0.572 rs11846404 chr14:104156108 C/G cg08213375 chr14:104286397 PPP1R13B 0.44 7.07 0.36 9.29e-12 Reticulocyte count; CRC cis rs6445525 0.967 rs6792662 chr3:65996707 G/C cg06109867 chr3:66002991 MAGI1 -0.39 -6.41 -0.33 5.06e-10 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs4713118 0.869 rs9461405 chr6:27719375 G/T cg06470822 chr6:28175283 NA 0.72 10.35 0.5 6.51e-22 Parkinson's disease; CRC cis rs4713118 0.568 rs9468213 chr6:27706180 G/A cg12273811 chr6:28175739 NA 0.44 6.34 0.33 7.69e-10 Parkinson's disease; CRC trans rs11098499 0.955 rs11944880 chr4:120159334 A/G cg25214090 chr10:38739885 LOC399744 -0.53 -8.18 -0.41 6.3e-15 Corneal astigmatism; CRC cis rs6089584 0.816 rs4925336 chr20:60627180 A/G cg23463467 chr20:60627584 TAF4 0.36 6.38 0.33 6.13e-10 Body mass index; CRC cis rs2933343 0.700 rs883602 chr3:128653952 A/G cg11901034 chr3:128598214 ACAD9 -0.57 -8.27 -0.41 3.4e-15 IgG glycosylation; CRC cis rs1552244 0.882 rs35056669 chr3:10014171 C/T cg02579736 chr3:10068473 FANCD2;CIDECP 0.93 12.04 0.55 6.82e-28 Alzheimer's disease; CRC cis rs7552404 0.924 rs1498317 chr1:76171984 A/C cg03433033 chr1:76189801 ACADM 0.92 14.06 0.61 1.66e-35 Blood metabolite levels;Acylcarnitine levels; CRC cis rs17253792 0.822 rs10129890 chr14:56040413 A/T cg01858014 chr14:56050164 KTN1 -0.83 -7.34 -0.38 1.7e-12 Putamen volume; CRC cis rs1976403 0.510 rs1697421 chr1:21823292 C/T cg00786952 chr1:21763130 NA 0.45 7.52 0.38 5.22e-13 Liver enzyme levels (alkaline phosphatase); CRC trans rs634537 0.559 rs643319 chr9:22017836 A/C cg18057959 chr10:126694753 CTBP2 -0.36 -6.14 -0.32 2.43e-9 Glioma;Non-glioblastoma glioma;Glioblastoma; CRC cis rs12142240 0.698 rs6679898 chr1:46820589 A/C cg00530320 chr1:46809349 NSUN4 0.59 8.03 0.41 1.69e-14 Menopause (age at onset); CRC cis rs8077889 0.672 rs1234612 chr17:41840802 A/G cg16892393 chr17:41919603 NA 0.35 5.67 0.3 3.11e-8 Triglycerides; CRC cis rs4380275 1.000 rs7562792 chr2:774469 T/C cg27237671 chr2:676223 TMEM18 -0.43 -6.18 -0.32 1.95e-9 Adverse response to chemotherapy (neutropenia/leucopenia) (doxorubicin); CRC cis rs1448094 0.512 rs6539925 chr12:86244358 A/G cg25456477 chr12:86230367 RASSF9 0.32 5.67 0.3 3.13e-8 Major depressive disorder; CRC cis rs992157 0.965 rs13419763 chr2:219134950 C/T cg00012203 chr2:219082015 ARPC2 0.53 8.62 0.43 2.82e-16 Colorectal cancer; CRC cis rs4731207 0.596 rs1471572 chr7:124650942 C/A cg23710748 chr7:124431027 NA -0.38 -6.08 -0.32 3.27e-9 Cutaneous malignant melanoma; CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg00424800 chr3:169755602 GPR160 -0.49 -6.03 -0.32 4.36e-9 Diisocyanate-induced asthma; CRC cis rs10504229 0.595 rs36081958 chr8:58117505 C/G cg21724239 chr8:58056113 NA 0.52 7.13 0.37 6.58e-12 Developmental language disorder (linguistic errors); CRC cis rs4319547 0.915 rs3803005 chr12:123110654 T/C cg05707623 chr12:122985044 ZCCHC8 -0.7 -8.89 -0.44 4.05e-17 Body mass index; CRC cis rs875971 0.964 rs11765965 chr7:65842221 A/G cg12463550 chr7:65579703 CRCP 0.48 6.96 0.36 1.89e-11 Aortic root size; CRC cis rs1448094 0.511 rs10863083 chr12:86226739 C/A cg25456477 chr12:86230367 RASSF9 0.32 5.65 0.3 3.56e-8 Major depressive disorder; CRC trans rs2303319 0.504 rs62189051 chr2:162622318 G/A cg23247704 chr1:116518985 SLC22A15 -0.72 -6.12 -0.32 2.7e-9 Cognitive function; CRC cis rs6484504 0.576 rs208072 chr11:31141288 A/G cg14844989 chr11:31128820 NA 0.33 5.73 0.3 2.31e-8 Red blood cell count; CRC cis rs9368481 0.594 rs7768814 chr6:26892036 C/A cg05192639 chr6:26864778 GUSBL1 0.34 6.1 0.32 3e-9 Autism spectrum disorder or schizophrenia; CRC cis rs2580764 0.566 rs2968795 chr2:55287989 G/A cg09592903 chr2:55203963 RTN4 0.7 11.22 0.53 5.89e-25 Mean platelet volume; CRC trans rs10504390 0.656 rs79616747 chr8:66546593 C/A cg26403416 chr21:43771339 TFF2 0.6 6.14 0.32 2.38e-9 IgG glycosylation; CRC cis rs561341 0.831 rs11658469 chr17:30206426 T/C cg00745463 chr17:30367425 LRRC37B 0.69 8.07 0.41 1.31e-14 Hip circumference adjusted for BMI; CRC cis rs13191362 1.000 rs34697913 chr6:163000187 T/C cg06582575 chr6:163149167 PACRG;PARK2 0.77 10.7 0.51 3.98e-23 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs10504229 1.000 rs67188507 chr8:58187492 A/T cg24829409 chr8:58192753 C8orf71 -0.68 -11.34 -0.53 2.27e-25 Developmental language disorder (linguistic errors); CRC cis rs6964587 1.000 rs6961928 chr7:91669808 C/T cg17063962 chr7:91808500 NA 0.83 14.63 0.63 1.08e-37 Breast cancer; CRC trans rs2727020 0.658 rs10839278 chr11:49450847 G/C cg15704280 chr7:45808275 SEPT13 -0.91 -17.34 -0.69 2.63e-48 Coronary artery disease; CRC cis rs7973719 1.000 rs1839622 chr12:7334534 G/C cg07052231 chr12:7363540 PEX5 0.5 8.16 0.41 7.04e-15 IgG glycosylation; CRC trans rs11764590 0.671 rs12669370 chr7:2081914 G/A cg11693508 chr17:37793320 STARD3 0.52 7.01 0.36 1.34e-11 Neuroticism; CRC cis rs11971779 0.648 rs7799165 chr7:139084957 G/T cg07862535 chr7:139043722 LUC7L2 0.57 7.35 0.38 1.61e-12 Diisocyanate-induced asthma; CRC cis rs9486715 0.867 rs7451950 chr6:96879974 T/C cg06623918 chr6:96969491 KIAA0776 1.02 20.3 0.75 5.5e-60 Headache; CRC cis rs6502050 0.835 rs12938965 chr17:80128646 G/A cg19223190 chr17:80058835 NA 0.38 6.02 0.32 4.64e-9 Life satisfaction; CRC cis rs1348850 0.872 rs2084233 chr2:178331206 G/A cg22681709 chr2:178499509 PDE11A -0.4 -7.35 -0.38 1.55e-12 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs17713451 0.593 rs17715460 chr7:151268858 G/A cg18404559 chr7:151322523 PRKAG2 -0.57 -6.41 -0.33 5.12e-10 Interleukin-4 levels; CRC cis rs7727544 0.507 rs10051679 chr5:131570931 T/A cg02033258 chr5:131593261 PDLIM4 0.46 8.52 0.43 5.87e-16 Blood metabolite levels; CRC cis rs7312933 0.645 rs11181404 chr12:42683840 T/C cg11827402 chr12:42719852 PPHLN1;ZCRB1 0.65 9.02 0.45 1.62e-17 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CRC cis rs769267 0.929 rs2965180 chr19:19491973 T/C cg02546618 chr19:19431379 KIAA0892;SF4 -0.45 -6.24 -0.33 1.33e-9 Tonsillectomy; CRC trans rs17126268 0.502 rs1934701 chr1:102882942 A/C cg18468354 chr14:36993517 NA 0.38 6.12 0.32 2.65e-9 Glomerular filtration rate; CRC cis rs35520189 0.591 rs12623837 chr2:113702468 A/G cg12858261 chr2:113808755 IL1F8 0.47 6.2 0.32 1.67e-9 Obstructive sleep apnea trait (apnea hypopnea index); CRC cis rs58688157 0.705 rs12419694 chr11:598033 C/T cg16486109 chr11:613632 IRF7 0.71 12.23 0.56 1.27e-28 Systemic lupus erythematosus; CRC cis rs2882667 0.690 rs160398 chr5:138063439 T/G cg09476006 chr5:138032270 NA 0.54 9.42 0.46 8.52e-19 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs11190604 1.000 rs2495737 chr10:102338344 T/C cg16342193 chr10:102329863 NA -0.37 -6.09 -0.32 3.18e-9 Palmitoleic acid (16:1n-7) levels; CRC cis rs1559088 1.000 rs12979164 chr19:33553228 G/C cg27124370 chr19:33622961 WDR88 0.4 5.63 0.3 3.85e-8 Bone ultrasound measurement (broadband ultrasound attenuation); CRC cis rs9910055 0.718 rs2526022 chr17:42213216 C/T cg09913183 chr17:42254507 C17orf65;ASB16 0.58 8.45 0.42 9.38e-16 Total body bone mineral density; CRC cis rs9308731 0.623 rs6708784 chr2:111927379 A/G cg18646521 chr2:111875858 NA 0.39 6.07 0.32 3.53e-9 Chronic lymphocytic leukemia; CRC cis rs10504229 0.728 rs17804774 chr8:58155950 G/T cg20607798 chr8:58055168 NA 0.46 5.74 0.3 2.13e-8 Developmental language disorder (linguistic errors); CRC cis rs751728 0.585 rs9380381 chr6:33771070 C/T cg25922239 chr6:33757077 LEMD2 0.47 6.33 0.33 8.13e-10 Crohn's disease; CRC trans rs11039798 0.925 rs6485831 chr11:48455031 A/T cg03929089 chr4:120376271 NA 0.64 6.22 0.32 1.5e-9 Axial length; CRC cis rs4731207 0.698 rs10223980 chr7:124536558 C/T cg23710748 chr7:124431027 NA -0.38 -6.06 -0.32 3.65e-9 Cutaneous malignant melanoma; CRC cis rs9768139 0.566 rs729099 chr7:158114152 C/T cg23298862 chr7:158159286 PTPRN2 0.39 6.43 0.33 4.44e-10 Calcium levels; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg21126573 chr17:7755257 KDM6B 0.45 6.57 0.34 2.02e-10 Intelligence (multi-trait analysis); CRC cis rs35146811 0.844 rs4729576 chr7:99692594 G/A cg13334819 chr7:99746414 C7orf59 -0.57 -7.58 -0.39 3.51e-13 Coronary artery disease; CRC cis rs7618915 0.531 rs77146033 chr3:52701501 G/T cg18099408 chr3:52552593 STAB1 -0.45 -7.37 -0.38 1.37e-12 Bipolar disorder; CRC cis rs1223397 0.938 rs3734878 chr6:13288850 C/T cg00460589 chr6:13274354 PHACTR1 0.5 6.01 0.31 4.79e-9 Blood pressure; CRC cis rs10782582 0.593 rs74968421 chr1:76233496 T/C cg05598546 chr1:76251766 SNORD45C;RABGGTB 0.44 5.79 0.3 1.64e-8 Daytime sleep phenotypes; CRC cis rs5769765 0.955 rs9616368 chr22:50303533 C/G cg04121214 chr22:50244548 NA 0.39 5.78 0.3 1.75e-8 Schizophrenia; CRC cis rs2160860 0.773 rs11777082 chr8:39797703 G/A cg11363097 chr8:39792086 IDO2 -0.42 -7.25 -0.37 2.94e-12 Blood metabolite levels; CRC cis rs1670533 0.872 rs11727136 chr4:1051804 G/A cg27284194 chr4:1044797 NA 0.51 6.35 0.33 7.31e-10 Recombination rate (females); CRC cis rs9311474 1.000 rs7614727 chr3:52295895 C/T cg18099408 chr3:52552593 STAB1 -0.47 -7.98 -0.4 2.46e-14 Electroencephalogram traits; CRC cis rs9928842 0.765 rs6564223 chr16:75225899 T/C cg09066997 chr16:75300724 BCAR1 0.63 5.89 0.31 9.7e-9 Alcoholic chronic pancreatitis; CRC cis rs3617 0.539 rs9880619 chr3:52953055 G/A cg18099408 chr3:52552593 STAB1 0.33 5.78 0.3 1.76e-8 Red blood cell count;Autism spectrum disorder or schizophrenia; CRC cis rs7927592 0.913 rs7925275 chr11:68290433 T/C cg16797656 chr11:68205561 LRP5 0.37 5.89 0.31 9.67e-9 Total body bone mineral density; CRC cis rs56399783 0.808 rs73049331 chr7:2799911 C/T cg19731401 chr7:2775893 GNA12 0.66 7.21 0.37 3.81e-12 Childhood ear infection; CRC cis rs4332037 0.826 rs4721188 chr7:1953615 G/A cg21155852 chr7:2048760 MAD1L1 0.45 6.32 0.33 8.51e-10 Bipolar disorder; CRC cis rs1552244 0.810 rs7612908 chr3:10089148 A/G cg10729496 chr3:10149963 C3orf24 0.55 7.26 0.37 2.73e-12 Alzheimer's disease; CRC cis rs72615157 0.634 rs74742883 chr7:99785765 T/G cg16268157 chr7:99778414 STAG3 -0.43 -5.72 -0.3 2.45e-8 Lung function (FEV1/FVC); CRC cis rs597539 0.616 rs513476 chr11:68698996 C/T cg06028808 chr11:68637592 NA 0.38 6.03 0.32 4.4e-9 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs1552244 1.000 rs6791810 chr3:10124444 A/G cg02579736 chr3:10068473 FANCD2;CIDECP -0.97 -13.04 -0.58 1.29e-31 Alzheimer's disease; CRC cis rs62432291 0.681 rs2501176 chr6:159655383 A/G cg14500486 chr6:159655392 FNDC1 -0.76 -10.4 -0.5 4.17e-22 Joint mobility (Beighton score); CRC cis rs1707322 0.890 rs2297883 chr1:46511487 G/C cg06784218 chr1:46089804 CCDC17 -0.55 -9.74 -0.47 7.37e-20 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs11212617 0.935 rs11212543 chr11:108054922 G/A cg12106634 chr11:108092400 ATM;NPAT 0.42 6.3 0.33 9.61e-10 Response to metformin in type 2 diabetes (glycemic); CRC cis rs7917772 0.582 rs6584512 chr10:104329685 A/G cg11453585 chr10:104263688 ACTR1A;SUFU 0.82 15.26 0.64 3.8e-40 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC cis rs10782582 0.546 rs79652169 chr1:76233882 G/A cg10523679 chr1:76189770 ACADM -0.44 -6.26 -0.33 1.19e-9 Daytime sleep phenotypes; CRC cis rs8141529 0.632 rs5762803 chr22:29193638 G/C cg15103426 chr22:29168792 CCDC117 0.58 8.17 0.41 6.67e-15 Lymphocyte counts; CRC cis rs9393692 0.620 rs9393691 chr6:26272829 T/C cg13736514 chr6:26305472 NA -0.43 -7.19 -0.37 4.35e-12 Educational attainment; CRC cis rs910316 0.967 rs11624893 chr14:75660124 A/G cg03030879 chr14:75389066 RPS6KL1 0.43 6.44 0.33 4.16e-10 Height; CRC cis rs7762018 1.000 rs74900588 chr6:170102180 A/C cg24289452 chr6:170231220 NA -0.6 -6.56 -0.34 2.12e-10 Thiazide-induced adverse metabolic effects in hypertensive patients; CRC trans rs17685 0.712 rs28506984 chr7:75763484 A/G cg19862616 chr7:65841803 NCRNA00174 1.0 18.44 0.71 1.18e-52 Coffee consumption;Coffee consumption (cups per day); CRC cis rs67478160 0.595 rs1475007 chr14:104297147 A/G cg01849466 chr14:104193079 ZFYVE21 -0.48 -8.39 -0.42 1.48e-15 Schizophrenia; CRC cis rs7945705 0.782 rs2742545 chr11:8884308 C/G cg00186954 chr11:8933980 ST5;C11orf17 -0.49 -8.29 -0.42 2.99e-15 Hemoglobin concentration; CRC cis rs116095464 0.558 rs28418643 chr5:240859 A/G cg22496380 chr5:211416 CCDC127 -0.91 -10.38 -0.5 5.2e-22 Breast cancer; CRC cis rs3741151 0.656 rs12290785 chr11:73259012 G/T cg17517138 chr11:73019481 ARHGEF17 0.83 7.15 0.37 5.59e-12 GIP levels in response to oral glucose tolerance test (120 minutes); CRC cis rs4713118 0.662 rs149947 chr6:27972433 A/T cg15845792 chr6:28175446 NA 0.86 12.58 0.57 6.56e-30 Parkinson's disease; CRC cis rs73206853 0.841 rs55864430 chr12:110932355 G/T cg12870014 chr12:110450643 ANKRD13A 0.77 7.44 0.38 8.97e-13 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC cis rs9649213 0.593 rs2394854 chr7:98027306 A/G cg21770322 chr7:97807741 LMTK2 0.52 8.59 0.43 3.61e-16 Prostate cancer (SNP x SNP interaction); CRC cis rs1639906 0.560 rs1639915 chr7:2258084 C/G cg19897017 chr7:2163380 MAD1L1 0.4 5.86 0.31 1.15e-8 Colonoscopy-negative controls vs population controls; CRC cis rs2153535 0.580 rs915350 chr6:8443486 A/G cg21535247 chr6:8435926 SLC35B3 0.48 7.2 0.37 4.22e-12 Motion sickness; CRC cis rs17270561 0.609 rs1892255 chr6:25750354 G/A cg16482183 chr6:26056742 HIST1H1C 0.81 9.93 0.48 1.71e-20 Iron status biomarkers; CRC cis rs12908161 0.959 rs34342559 chr15:85331271 A/G cg11189052 chr15:85197271 WDR73 0.59 8.36 0.42 1.75e-15 Schizophrenia; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg21798447 chr4:85504053 CDS1 0.38 6.38 0.33 5.86e-10 Liver disease severity in Alagille syndrome; CRC trans rs6550704 0.687 rs9865314 chr3:22634337 A/G cg01337508 chr17:40540572 STAT3 -0.41 -6.1 -0.32 2.93e-9 Daytime sleep phenotypes; CRC cis rs6502050 0.835 rs7219180 chr17:80079968 C/G cg11859384 chr17:80120422 CCDC57 0.37 5.77 0.3 1.85e-8 Life satisfaction; CRC cis rs7605827 0.897 rs7572509 chr2:15597288 C/T cg19274914 chr2:15703543 NA 0.38 5.81 0.3 1.49e-8 Educational attainment (years of education); CRC cis rs9611565 0.512 rs5758450 chr22:42141640 G/A cg06634786 chr22:41940651 POLR3H 0.68 7.74 0.39 1.2e-13 Vitiligo; CRC cis rs6502050 0.799 rs11491185 chr17:80151101 C/T cg22110888 chr17:80059540 CCDC57 0.4 6.24 0.33 1.33e-9 Life satisfaction; CRC cis rs7973719 0.833 rs3825405 chr12:7360143 G/T cg07052231 chr12:7363540 PEX5 0.51 8.25 0.41 3.79e-15 IgG glycosylation; CRC cis rs7932354 0.528 rs7931260 chr11:47088303 T/C cg03339077 chr11:47165057 C11orf49 0.43 5.95 0.31 6.94e-9 Bone mineral density (hip);Bone mineral density; CRC cis rs1448094 0.791 rs10863124 chr12:86352548 A/T cg00310523 chr12:86230176 RASSF9 0.41 6.9 0.36 2.65e-11 Major depressive disorder; CRC cis rs1075232 0.649 rs67157590 chr15:32130119 G/C cg08481732 chr15:32323009 CHRNA7 0.64 5.63 0.3 3.9e-8 Survival in colorectal cancer (non-distant metastatic); CRC cis rs4555082 1.000 rs7146643 chr14:105757392 A/G cg06808227 chr14:105710500 BRF1 -0.56 -8.62 -0.43 2.78e-16 Mean platelet volume;Platelet distribution width; CRC cis rs1832871 0.672 rs9457337 chr6:158726292 C/T cg07165851 chr6:158734300 TULP4 0.62 7.76 0.39 1.07e-13 Height; CRC cis rs891088 0.677 rs13306455 chr19:7184721 C/T cg09779027 chr19:7224513 INSR -0.57 -6.13 -0.32 2.49e-9 Hip circumference adjusted for BMI;Height; CRC cis rs13256369 0.901 rs12681298 chr8:8566235 A/G cg00074818 chr8:8560427 CLDN23 -0.39 -7.56 -0.38 4.16e-13 Obesity-related traits; CRC cis rs12500482 1.000 rs12500482 chr4:2430235 A/G cg01601518 chr4:2404284 ZFYVE28 -0.35 -5.61 -0.3 4.23e-8 Cognitive function; CRC cis rs7811142 0.779 rs77370288 chr7:99947897 A/T cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.95 12.51 0.57 1.27e-29 Platelet count; CRC cis rs2180341 0.960 rs7766802 chr6:127709871 T/G cg27446573 chr6:127587934 RNF146 0.98 13.19 0.59 3.63e-32 Breast cancer; CRC trans rs6762477 0.748 rs9831967 chr3:50217234 C/T cg21665057 chr3:196295764 WDR53;FBXO45 -0.44 -6.62 -0.34 1.47e-10 Menarche (age at onset); CRC cis rs11711311 0.911 rs9817327 chr3:113478500 A/G cg15478005 chr3:113465772 ATP6V1A;NAA50 0.45 6.3 0.33 9.55e-10 IgG glycosylation; CRC cis rs7726839 0.540 rs72703080 chr5:595238 A/G cg14541582 chr5:601475 NA -0.35 -7.03 -0.36 1.23e-11 Obesity-related traits; CRC cis rs7680126 0.596 rs4698029 chr4:10312798 C/G cg00071950 chr4:10020882 SLC2A9 0.46 6.24 0.33 1.36e-9 Urate levels in lean individuals;Urate levels in overweight individuals;Urate levels in obese individuals; CRC cis rs4716602 0.596 rs10261230 chr7:156159632 C/T cg16983916 chr7:156159713 NA -0.39 -6.9 -0.36 2.74e-11 Anti-saccade response; CRC cis rs6502050 0.805 rs7225560 chr17:80160884 C/G cg22110888 chr17:80059540 CCDC57 0.4 6.37 0.33 6.4e-10 Life satisfaction; CRC cis rs7726839 0.578 rs10080150 chr5:593160 C/T cg16447950 chr5:562315 NA 0.52 9.11 0.45 8.26e-18 Obesity-related traits; CRC cis rs728616 0.614 rs61859199 chr10:82118613 G/T cg11900509 chr10:81946545 ANXA11 -0.56 -6.3 -0.33 9.41e-10 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs12477438 0.765 rs62154861 chr2:99590235 T/C cg26064155 chr2:99771622 LIPT1;TSGA10 -0.77 -10.91 -0.52 7.49e-24 Chronic sinus infection; CRC cis rs6762 0.719 rs28655651 chr11:837121 G/C cg03885332 chr11:832357 CD151 -0.42 -6.37 -0.33 6.2e-10 Mean platelet volume; CRC cis rs853679 0.760 rs2299029 chr6:28198831 G/A cg12172441 chr6:28176163 NA 0.56 5.99 0.31 5.5e-9 Depression; CRC cis rs6570726 0.875 rs368744 chr6:145812622 A/G cg05347473 chr6:146136440 FBXO30 0.37 5.81 0.31 1.48e-8 Lobe attachment (rater-scored or self-reported); CRC cis rs1348850 0.651 rs1901824 chr2:178225466 T/C cg02961200 chr2:178257176 LOC100130691;AGPS 0.47 6.64 0.34 1.29e-10 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs59918340 0.764 rs4961256 chr8:142229946 G/A cg23750338 chr8:142222470 SLC45A4 0.6 11.14 0.52 1.12e-24 Immature fraction of reticulocytes; CRC cis rs11195062 0.521 rs4562740 chr10:111951930 C/A cg00817464 chr10:111662876 XPNPEP1 -0.41 -6.34 -0.33 7.76e-10 Multiple myeloma; CRC trans rs2243480 0.831 rs57294491 chr7:65684901 T/A cg10756647 chr7:56101905 PSPH -0.78 -8.11 -0.41 1.03e-14 Diabetic kidney disease; CRC cis rs2836974 0.584 rs6517535 chr21:40653352 G/C cg11890956 chr21:40555474 PSMG1 -0.91 -15.92 -0.66 1.01e-42 Cognitive function; CRC cis rs11958404 0.929 rs79656592 chr5:157430291 G/A cg05962755 chr5:157440814 NA 1.02 12.62 0.57 4.6e-30 IgG glycosylation; CRC cis rs10089 0.953 rs1036171 chr5:127402798 C/T cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.7 9.92 0.48 1.86e-20 Ileal carcinoids; CRC cis rs7223966 1.000 rs11657120 chr17:61857218 G/A cg23090583 chr17:61904693 PSMC5;FTSJ3 0.5 6.2 0.32 1.69e-9 Hip circumference adjusted for BMI;Body mass index; CRC cis rs7487075 0.820 rs7976362 chr12:46709562 A/G cg22049899 chr12:47219821 SLC38A4 0.33 6.24 0.33 1.36e-9 Itch intensity from mosquito bite; CRC cis rs3733585 0.648 rs7376155 chr4:9952588 C/T cg11266682 chr4:10021025 SLC2A9 -0.47 -9.62 -0.47 1.76e-19 Cleft plate (environmental tobacco smoke interaction); CRC trans rs2303319 0.504 rs16845997 chr2:162521046 C/A cg18122310 chr12:50236657 BCDIN3D -0.74 -6.19 -0.32 1.81e-9 Cognitive function; CRC cis rs4076764 0.846 rs7525724 chr1:163426372 G/A cg24596788 chr1:163392923 NA -0.57 -8.95 -0.44 2.62e-17 Motion sickness; CRC trans rs2303319 0.504 rs62189048 chr2:162613494 G/C cg14875682 chr5:52083620 ITGA1;PELO -0.73 -6.16 -0.32 2.11e-9 Cognitive function; CRC cis rs2836950 0.502 rs2150411 chr21:40574552 G/T cg11644478 chr21:40555479 PSMG1 -0.49 -7.31 -0.37 2.09e-12 Menarche (age at onset); CRC cis rs67311347 0.956 rs13066971 chr3:40462510 A/T cg09455208 chr3:40491958 NA -0.43 -8.84 -0.44 6.05e-17 Renal cell carcinoma; CRC cis rs6499255 1.000 rs4078387 chr16:69814047 G/A cg04110750 chr16:69646130 NFAT5 -0.52 -6.91 -0.36 2.54e-11 IgE levels; CRC cis rs7512552 0.803 rs3738487 chr1:150477061 C/T cg15654264 chr1:150340011 RPRD2 0.61 8.45 0.42 9.5e-16 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); CRC cis rs921968 0.643 rs492400 chr2:219349752 C/T cg02176678 chr2:219576539 TTLL4 0.46 7.38 0.38 1.34e-12 Mean corpuscular hemoglobin concentration; CRC cis rs9682041 0.696 rs10936627 chr3:170104406 C/T cg11886554 chr3:170076028 SKIL 0.69 8.26 0.41 3.51e-15 Glomerular filtration rate in non diabetics (creatinine);Glomerular filtration rate (creatinine); CRC trans rs4869931 0.858 rs9480514 chr6:150992337 C/A cg01367992 chr1:160766535 LY9 0.38 5.99 0.31 5.4e-9 Systolic blood pressure in sickle cell anemia; CRC cis rs875971 0.862 rs4149461 chr7:65744732 T/C cg11764359 chr7:65958608 NA -0.6 -9.34 -0.46 1.49e-18 Aortic root size; CRC trans rs7615952 0.599 rs6779141 chr3:125709995 A/T cg07211511 chr3:129823064 LOC729375 -0.78 -10.8 -0.51 1.75e-23 Blood pressure (smoking interaction); CRC trans rs11039798 0.582 rs1483119 chr11:48382334 A/G cg15704280 chr7:45808275 SEPT13 -0.66 -6.97 -0.36 1.79e-11 Axial length; CRC cis rs801193 1.000 rs4279493 chr7:66226620 C/T cg18876405 chr7:65276391 NA 0.59 10.55 0.5 1.35e-22 Aortic root size; CRC cis rs3764400 0.567 rs16953941 chr17:46296204 C/A cg10706073 chr17:46328419 SKAP1 -0.61 -6.65 -0.34 1.23e-10 Body mass index; CRC cis rs4660306 1.000 rs2356559 chr1:45981512 A/G cg03123370 chr1:45965343 CCDC163P;MMACHC -0.56 -8.12 -0.41 9.33e-15 Homocysteine levels; CRC cis rs524281 0.861 rs10896081 chr11:65880354 A/T cg14036092 chr11:66035641 RAB1B -0.47 -5.72 -0.3 2.43e-8 Electroencephalogram traits; CRC cis rs208520 0.690 rs12209753 chr6:66703951 A/G cg07460842 chr6:66804631 NA 1.04 14.64 0.63 1.04e-37 Exhaled nitric oxide output; CRC cis rs8060686 0.641 rs55682260 chr16:68057880 G/A cg08314208 chr16:67682810 RLTPR -0.67 -6.98 -0.36 1.67e-11 HDL cholesterol;Metabolic syndrome; CRC cis rs1862618 0.671 rs2255726 chr5:56243128 T/C cg24531977 chr5:56204891 C5orf35 0.66 10.23 0.49 1.61e-21 Initial pursuit acceleration; CRC trans rs11039798 0.623 rs594615 chr11:48402804 T/C cg03929089 chr4:120376271 NA -0.63 -6.58 -0.34 1.86e-10 Axial length; CRC cis rs854572 0.600 rs705382 chr7:94955221 C/G cg17330251 chr7:94953956 PON1 -0.72 -12.64 -0.57 3.9e-30 Paraoxonase activity; CRC cis rs72781680 0.678 rs872169 chr2:24259188 C/G cg06627628 chr2:24431161 ITSN2 -0.53 -5.84 -0.31 1.27e-8 Lymphocyte counts; CRC cis rs763121 0.853 rs6001182 chr22:39047443 A/G cg06022373 chr22:39101656 GTPBP1 0.78 12.39 0.56 3.54e-29 Menopause (age at onset); CRC cis rs1357245 0.692 rs73036931 chr3:27205135 G/A cg02860705 chr3:27208620 NA -0.39 -5.84 -0.31 1.25e-8 Breast cancer; CRC cis rs1348850 0.914 rs8941 chr2:178406481 C/T cg02961200 chr2:178257176 LOC100130691;AGPS 0.58 8.26 0.41 3.54e-15 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs7833790 0.660 rs7839178 chr8:82763479 A/G cg27398817 chr8:82754497 SNX16 0.44 6.03 0.32 4.44e-9 Diastolic blood pressure; CRC cis rs7772486 0.902 rs2777480 chr6:146309983 T/A cg23711669 chr6:146136114 FBXO30 0.61 10.18 0.49 2.35e-21 Lobe attachment (rater-scored or self-reported); CRC cis rs2274273 0.774 rs17128440 chr14:55861912 C/T cg23234261 chr14:55582407 NA -0.29 -5.87 -0.31 1.07e-8 Protein biomarker; CRC cis rs13256369 1.000 rs13271966 chr8:8575472 T/C cg17143192 chr8:8559678 CLDN23 0.48 6.41 0.33 5.03e-10 Obesity-related traits; CRC cis rs11212617 1.000 rs11212610 chr11:108274593 T/C cg14761454 chr11:108092087 ATM;NPAT 0.42 6.14 0.32 2.37e-9 Response to metformin in type 2 diabetes (glycemic); CRC cis rs727505 1.000 rs2286175 chr7:124431032 G/A cg23710748 chr7:124431027 NA -0.84 -14.23 -0.62 3.77e-36 Lewy body disease; CRC cis rs1881396 0.891 rs2141372 chr2:27827196 G/T cg27432699 chr2:27873401 GPN1 0.62 8.28 0.42 3.12e-15 Nonalcoholic fatty liver disease; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg08305742 chr2:88354927 KRCC1 0.4 6.29 0.33 1.03e-9 Liver disease severity in Alagille syndrome; CRC trans rs1005277 0.540 rs2474598 chr10:38430296 C/T cg17830980 chr10:43048298 ZNF37B 0.6 9.88 0.48 2.5e-20 Extrinsic epigenetic age acceleration; CRC cis rs7586879 0.616 rs13410999 chr2:25097939 T/C cg22495460 chr2:25135724 ADCY3 -0.85 -16.31 -0.67 3.12e-44 Body mass index; CRC cis rs2295359 0.963 rs12030867 chr1:67627620 T/C cg03340356 chr1:67600835 NA 0.26 6.0 0.31 5.14e-9 Psoriasis; CRC cis rs5758511 0.773 rs11913631 chr22:42347371 G/T cg00645731 chr22:42541494 CYP2D7P1 0.45 6.88 0.35 3.04e-11 Birth weight; CRC cis rs7223966 1.000 rs72848797 chr17:61934664 G/A cg05941027 chr17:61774174 LIMD2 0.34 5.81 0.3 1.51e-8 Hip circumference adjusted for BMI;Body mass index; CRC cis rs9560113 1.000 rs9560113 chr13:112183348 A/G cg10483660 chr13:112241077 NA 0.36 5.82 0.31 1.37e-8 Menarche (age at onset); CRC cis rs13315871 0.860 rs9842759 chr3:58244748 C/T cg20936604 chr3:58311152 NA -0.67 -6.82 -0.35 4.3e-11 Cholesterol, total; CRC cis rs3858526 0.514 rs1530973 chr11:5861449 C/T cg02574844 chr11:5959923 NA -0.49 -7.07 -0.36 9.39e-12 DNA methylation (variation); CRC cis rs801193 0.839 rs6968619 chr7:66068867 T/C cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.42 -6.22 -0.32 1.55e-9 Aortic root size; CRC cis rs10411161 0.702 rs7250193 chr19:52385520 C/T cg11269599 chr19:52391304 ZNF577 -0.48 -5.93 -0.31 7.77e-9 Breast cancer; CRC cis rs12893668 0.514 rs3212090 chr14:104168863 C/T cg08213375 chr14:104286397 PPP1R13B 0.46 7.4 0.38 1.15e-12 Reticulocyte count; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg19027619 chr1:6674655 PHF13 0.38 6.23 0.32 1.43e-9 Liver disease severity in Alagille syndrome; CRC cis rs1816752 0.905 rs9511260 chr13:25011176 T/C cg02811702 chr13:24901961 NA 0.47 6.59 0.34 1.7e-10 Obesity-related traits; CRC cis rs2985684 1.000 rs2985697 chr14:50092902 A/G cg23565292 chr14:50234668 KLHDC2 -0.4 -6.0 -0.31 5.3e-9 Carotid intima media thickness; CRC cis rs561341 1.000 rs506766 chr17:30289659 T/C cg19193384 chr17:30244184 NA -0.66 -7.39 -0.38 1.22e-12 Hip circumference adjusted for BMI; CRC cis rs9443645 0.527 rs1415859 chr6:79794858 A/G cg05283184 chr6:79620031 NA -0.43 -6.05 -0.32 3.95e-9 Intelligence (multi-trait analysis); CRC cis rs6121246 0.909 rs6060633 chr20:30263317 G/T cg13852791 chr20:30311386 BCL2L1 0.69 11.0 0.52 3.61e-24 Mean corpuscular hemoglobin; CRC cis rs4076764 0.846 rs12035840 chr1:163419177 G/C cg24596788 chr1:163392923 NA -0.58 -9.26 -0.45 2.65e-18 Motion sickness; CRC cis rs7932354 0.536 rs1551744 chr11:46865000 G/A cg19486271 chr11:47235900 DDB2 -0.44 -6.62 -0.34 1.45e-10 Bone mineral density (hip);Bone mineral density; CRC cis rs7552404 0.924 rs1146581 chr1:76213024 T/G cg03433033 chr1:76189801 ACADM 0.8 12.15 0.56 2.53e-28 Blood metabolite levels;Acylcarnitine levels; CRC cis rs9303542 0.625 rs11868098 chr17:46570869 C/G cg04904318 chr17:46607828 HOXB1 0.43 5.62 0.3 3.98e-8 Ovarian cancer;Epithelial ovarian cancer; CRC cis rs1568889 1.000 rs7102106 chr11:28343953 G/A cg06544937 chr11:28130018 METT5D1;KIF18A 0.79 10.96 0.52 5.09e-24 Bipolar disorder; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg09067967 chr4:39529342 UGDH 0.36 6.13 0.32 2.54e-9 Liver disease severity in Alagille syndrome; CRC cis rs7264396 0.887 rs6060434 chr20:34068382 C/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.39 -6.44 -0.33 4.22e-10 Total cholesterol levels; CRC cis rs2976388 0.578 rs13263987 chr8:143827387 A/C cg22687807 chr8:143858763 LYNX1 -0.45 -7.07 -0.36 9.33e-12 Urinary tract infection frequency; CRC cis rs6952808 0.575 rs6950330 chr7:1953606 T/C cg02951883 chr7:2050386 MAD1L1 -0.53 -8.86 -0.44 5.18e-17 Bipolar disorder and schizophrenia; CRC cis rs2033711 0.870 rs6510152 chr19:58953319 C/T cg26874164 chr19:58962979 ZNF324B 0.42 5.8 0.3 1.58e-8 Uric acid clearance; CRC trans rs4650994 1.000 rs10913571 chr1:178526648 A/T cg05059571 chr16:84539110 KIAA1609 -0.46 -6.99 -0.36 1.58e-11 HDL cholesterol levels;HDL cholesterol; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg14552354 chr19:9785341 ZNF562 0.43 6.17 0.32 2.02e-9 Intelligence (multi-trait analysis); CRC cis rs1862618 0.853 rs1862619 chr5:56098256 T/A cg24531977 chr5:56204891 C5orf35 -0.77 -10.3 -0.49 9.5e-22 Initial pursuit acceleration; CRC cis rs11711311 1.000 rs9865435 chr3:113450046 G/C cg15478005 chr3:113465772 ATP6V1A;NAA50 0.45 6.15 0.32 2.19e-9 IgG glycosylation; CRC cis rs2242194 0.816 rs2242193 chr1:154995503 A/G cg09359103 chr1:154839909 KCNN3 0.4 5.92 0.31 8.17e-9 Schizophrenia; CRC cis rs916888 0.821 rs199513 chr17:44856932 A/G cg15921436 chr17:44337874 NA -0.65 -7.64 -0.39 2.43e-13 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs2153535 0.580 rs7743686 chr6:8526111 A/G cg07606381 chr6:8435919 SLC35B3 0.68 11.04 0.52 2.51e-24 Motion sickness; CRC cis rs4481887 0.741 rs6682953 chr1:248535626 T/C cg26353448 chr1:248524236 OR2T4 -0.35 -6.57 -0.34 1.93e-10 Common traits (Other); CRC cis rs1624802 1.000 rs1624802 chr12:130497472 C/T cg15444478 chr12:130494697 NA 0.29 5.92 0.31 7.94e-9 Obesity-related traits; CRC cis rs2976388 0.507 rs7813604 chr8:143838062 G/A cg22687807 chr8:143858763 LYNX1 0.61 10.84 0.51 1.29e-23 Urinary tract infection frequency; CRC cis rs9398803 0.865 rs2184967 chr6:126773487 C/T cg19875578 chr6:126661172 C6orf173 0.43 5.87 0.31 1.09e-8 Male-pattern baldness; CRC cis rs9549328 0.589 rs36164841 chr13:113616579 A/G cg24588162 chr13:113633484 MCF2L 0.36 6.43 0.33 4.47e-10 Systolic blood pressure; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg11156230 chr4:83351251 HNRPDL;ENOPH1 0.52 7.14 0.37 6.11e-12 Anxiety disorder; CRC cis rs4975709 0.589 rs4975747 chr5:1862836 G/A cg20790798 chr5:1857306 NA -0.41 -6.29 -0.33 1e-9 Cardiovascular disease risk factors; CRC trans rs9747201 0.925 rs7209621 chr17:80057099 C/T cg07393940 chr7:158741817 NA -0.56 -7.84 -0.4 6.47e-14 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs8180040 0.767 rs11920853 chr3:47308183 G/A cg27129171 chr3:47204927 SETD2 -0.66 -9.98 -0.48 1.13e-20 Colorectal cancer; CRC cis rs853679 0.546 rs200954 chr6:27838764 C/G cg19041857 chr6:27730383 NA -0.71 -6.71 -0.35 8.65e-11 Depression; CRC trans rs11098499 0.954 rs7687843 chr4:120421211 C/T cg25214090 chr10:38739885 LOC399744 0.65 10.15 0.49 3.02e-21 Corneal astigmatism; CRC cis rs4727027 0.901 rs1137432 chr7:148801658 C/T cg12479418 chr7:148823350 ZNF425;ZNF398 0.47 6.36 0.33 6.7e-10 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC cis rs6764363 0.527 rs3872654 chr3:282657 G/C cg02057681 chr3:285234 CHL1 0.42 7.08 0.36 8.63e-12 Sudden cardiac arrest; CRC trans rs561341 1.000 rs117979353 chr17:30272866 A/G cg27661571 chr11:113659931 NA -0.96 -11.24 -0.53 5.07e-25 Hip circumference adjusted for BMI; CRC cis rs11098499 0.863 rs12508173 chr4:120318526 T/C cg09307838 chr4:120376055 NA 0.7 10.81 0.51 1.71e-23 Corneal astigmatism; CRC cis rs6570726 1.000 rs455109 chr6:145872665 C/T cg23711669 chr6:146136114 FBXO30 0.72 12.46 0.57 1.82e-29 Lobe attachment (rater-scored or self-reported); CRC cis rs6502050 0.749 rs7406163 chr17:80086389 C/T cg09264619 chr17:80180166 NA 0.38 6.44 0.33 4.28e-10 Life satisfaction; CRC cis rs13108904 0.870 rs11721789 chr4:1254414 C/A cg23123621 chr4:1343375 KIAA1530 0.32 5.64 0.3 3.65e-8 Obesity-related traits; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg16020249 chr1:27930640 AHDC1 0.42 7.18 0.37 4.59e-12 Liver disease severity in Alagille syndrome; CRC cis rs4481887 0.962 rs6587452 chr1:248485931 C/T cg00666640 chr1:248458726 OR2T12 0.55 9.57 0.47 2.71e-19 Common traits (Other); CRC cis rs10982256 0.846 rs10817622 chr9:117242575 T/C cg13636371 chr9:117264095 DFNB31 0.34 6.3 0.33 9.49e-10 Bipolar disorder; CRC cis rs7259376 0.905 rs56027264 chr19:22554354 T/C cg02657401 chr19:22469223 NA -0.32 -7.02 -0.36 1.3e-11 Menopause (age at onset); CRC trans rs561341 1.000 rs72825740 chr17:30338356 A/G cg20587970 chr11:113659929 NA -1.43 -20.05 -0.74 5.67e-59 Hip circumference adjusted for BMI; CRC cis rs1059312 0.808 rs2306683 chr12:129299675 C/G cg09035930 chr12:129282057 SLC15A4 0.52 8.7 0.43 1.68e-16 Systemic lupus erythematosus; CRC cis rs12472274 0.646 rs2305171 chr2:239097140 G/A cg17459225 chr2:239074497 NA 0.67 7.7 0.39 1.63e-13 Phospholipid levels (plasma); CRC cis rs904251 0.523 rs2797799 chr6:37483620 T/G cg01843034 chr6:37503916 NA -0.43 -8.11 -0.41 9.84e-15 Cognitive performance; CRC cis rs6952808 0.792 rs12531315 chr7:1953650 C/G cg21782813 chr7:2030301 MAD1L1 0.45 7.63 0.39 2.55e-13 Bipolar disorder and schizophrenia; CRC cis rs77106637 0.860 rs1552224 chr11:72433098 A/C cg03713592 chr11:72463424 ARAP1 1.15 11.19 0.53 7.52e-25 Type 2 diabetes; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg22717607 chr5:10353969 MARCH6 0.38 6.22 0.32 1.52e-9 Liver disease severity in Alagille syndrome; CRC cis rs2115630 0.936 rs8033459 chr15:85253258 C/T cg12501888 chr15:85177176 SCAND2 -0.36 -5.81 -0.31 1.47e-8 P wave terminal force; CRC cis rs8072100 0.935 rs78737171 chr17:45668760 A/T cg08085267 chr17:45401833 C17orf57 0.61 9.65 0.47 1.44e-19 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs13191362 0.872 rs36069443 chr6:163248701 T/C cg06582575 chr6:163149167 PACRG;PARK2 0.7 8.88 0.44 4.39e-17 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs12745968 0.624 rs1059268 chr1:92975244 T/A cg17283838 chr1:93427260 FAM69A -0.48 -6.49 -0.34 3.16e-10 Bipolar disorder and schizophrenia; CRC cis rs9611565 0.838 rs4239894 chr22:41745548 C/G cg06634786 chr22:41940651 POLR3H -0.56 -6.79 -0.35 5.29e-11 Vitiligo; CRC cis rs738322 0.934 rs133019 chr22:38573035 A/G cg17652424 chr22:38574118 PLA2G6 -0.21 -6.44 -0.33 4.17e-10 Cutaneous nevi; CRC trans rs66759488 0.739 rs10851451 chr15:47608991 A/G cg05350293 chr16:89119002 NA -0.36 -7.02 -0.36 1.26e-11 Lung cancer; CRC cis rs1552244 1.000 rs9845756 chr3:10067548 G/C cg00166722 chr3:10149974 C3orf24 0.66 8.88 0.44 4.36e-17 Alzheimer's disease; CRC cis rs6460942 0.556 rs10228123 chr7:12374025 A/C cg20607287 chr7:12443886 VWDE -0.49 -6.84 -0.35 3.84e-11 Coronary artery disease; CRC cis rs10504229 0.683 rs59528137 chr8:58138565 C/T cg05313129 chr8:58192883 C8orf71 -0.5 -5.89 -0.31 9.49e-9 Developmental language disorder (linguistic errors); CRC cis rs12325245 0.536 rs71375919 chr16:58547522 C/T cg26666090 chr16:58549219 SETD6 0.94 6.4 0.33 5.36e-10 Schizophrenia; CRC cis rs11190604 0.767 rs7076606 chr10:102192267 T/C cg07080220 chr10:102295463 HIF1AN 0.51 6.36 0.33 6.74e-10 Palmitoleic acid (16:1n-7) levels; CRC cis rs9910055 0.529 rs368328 chr17:42170289 G/A cg09913183 chr17:42254507 C17orf65;ASB16 -0.48 -6.6 -0.34 1.64e-10 Total body bone mineral density; CRC cis rs7215564 0.908 rs4889783 chr17:78667160 C/T cg09596252 chr17:78655493 RPTOR 0.55 6.09 0.32 3.19e-9 Myopia (pathological); CRC cis rs370915 0.928 rs433477 chr4:187814866 C/G cg19519643 chr4:187840862 NA 0.41 6.16 0.32 2.17e-9 Gout; CRC cis rs10504229 0.769 rs17804383 chr8:58151830 A/G cg24829409 chr8:58192753 C8orf71 -0.58 -7.96 -0.4 2.86e-14 Developmental language disorder (linguistic errors); CRC cis rs7666738 0.830 rs4619898 chr4:98959646 G/A cg05340658 chr4:99064831 C4orf37 0.61 9.54 0.47 3.45e-19 Colonoscopy-negative controls vs population controls; CRC cis rs7527798 0.592 rs6702222 chr1:207825627 C/T cg21110645 chr1:207815933 NA -0.39 -6.18 -0.32 1.9e-9 Erythrocyte sedimentation rate; CRC cis rs6840360 1.000 rs6846114 chr4:152604558 A/G cg09659197 chr4:152720779 NA -0.47 -10.03 -0.48 7.57e-21 Intelligence (multi-trait analysis); CRC trans rs7618501 1.000 rs11130218 chr3:49752372 C/T cg21582582 chr3:182698605 DCUN1D1 -0.54 -7.93 -0.4 3.37e-14 Intelligence (multi-trait analysis); CRC trans rs11098499 0.575 rs9996586 chr4:120326942 A/G cg25214090 chr10:38739885 LOC399744 0.42 6.57 0.34 1.93e-10 Corneal astigmatism; CRC cis rs10197940 0.662 rs1047957 chr2:152333773 C/T cg06191203 chr2:152266755 RIF1 -0.6 -8.79 -0.44 8.48e-17 Lung cancer; CRC cis rs6952808 0.756 rs12537348 chr7:1948172 C/G cg02951883 chr7:2050386 MAD1L1 -0.69 -10.94 -0.52 5.7e-24 Bipolar disorder and schizophrenia; CRC trans rs4714291 0.792 rs9471241 chr6:40080211 C/T cg02267698 chr19:7991119 CTXN1 -0.51 -7.0 -0.36 1.43e-11 Strep throat; CRC cis rs936229 0.813 rs3784790 chr15:75081745 G/C cg14664628 chr15:75095509 CSK -1.02 -19.9 -0.74 2.09e-58 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); CRC cis rs7715806 0.500 rs2307115 chr5:74990348 T/C cg19683494 chr5:74908142 NA 0.59 6.59 0.34 1.79e-10 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC trans rs3749237 0.964 rs13084243 chr3:49821878 G/C cg21665057 chr3:196295764 WDR53;FBXO45 0.51 6.94 0.36 2.07e-11 Resting heart rate; CRC cis rs2854207 0.505 rs2466957 chr17:61961230 G/C cg23903597 chr17:61704154 MAP3K3 -0.44 -5.96 -0.31 6.41e-9 Height; CRC cis rs7044106 0.734 rs12553070 chr9:123485266 C/T cg14255062 chr9:123606675 PSMD5;LOC253039 0.48 7.27 0.37 2.69e-12 Hip circumference adjusted for BMI; CRC trans rs2797160 0.967 rs6910786 chr6:126017141 A/T cg05039488 chr6:79577232 IRAK1BP1 0.51 7.59 0.39 3.37e-13 Endometrial cancer; CRC cis rs1799949 1.000 rs1399323 chr17:41332330 T/C cg01879757 chr17:41196368 BRCA1 -0.44 -6.69 -0.35 9.41e-11 Menopause (age at onset); CRC cis rs9303280 0.806 rs10852935 chr17:38031674 C/T cg17344932 chr17:38183730 MED24;SNORD124 0.36 5.83 0.31 1.35e-8 Self-reported allergy; CRC cis rs873946 0.586 rs3793682 chr10:134564563 C/T cg26818010 chr10:134567672 INPP5A -0.71 -9.2 -0.45 4.39e-18 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CRC cis rs832540 0.931 rs832536 chr5:56212595 C/T cg18230493 chr5:56204884 C5orf35 -0.4 -5.96 -0.31 6.6e-9 Coronary artery disease; CRC cis rs34779708 0.966 rs11010135 chr10:35518063 A/G cg03585969 chr10:35415529 CREM 0.6 7.88 0.4 5e-14 Inflammatory bowel disease;Crohn's disease; CRC cis rs4665809 0.589 rs4665841 chr2:26448950 G/A cg08067268 chr2:26466485 HADHB;HADHA -0.64 -8.39 -0.42 1.44e-15 Gut microbiome composition (summer); CRC cis rs71007656 1 rs71007656 chr10:37970845 CGGCTG/C cg00409905 chr10:38381863 ZNF37A -0.63 -10.02 -0.48 8.61e-21 Extrinsic epigenetic age acceleration; CRC cis rs3804749 0.966 rs9820435 chr3:122846881 C/T cg26084141 chr3:122786895 PDIA5 0.22 5.75 0.3 2.03e-8 Plateletcrit;Mean platelet volume;Platelet count;Platelet distribution width; CRC cis rs1129187 0.755 rs9471986 chr6:42944127 A/G cg05552183 chr6:42928497 GNMT 0.52 7.98 0.4 2.46e-14 Alzheimer's disease in APOE e4+ carriers; CRC cis rs853679 0.760 rs9368563 chr6:28208558 A/G cg06470822 chr6:28175283 NA 0.76 8.05 0.41 1.49e-14 Depression; CRC cis rs7914558 0.966 rs1890185 chr10:104748718 A/G cg15744005 chr10:104629667 AS3MT -0.34 -7.31 -0.37 2.02e-12 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs6120849 0.754 rs6120790 chr20:33599090 A/T cg08999081 chr20:33150536 PIGU 0.44 5.65 0.3 3.39e-8 Protein C levels; CRC cis rs10504229 0.728 rs17804774 chr8:58155950 G/T cg24829409 chr8:58192753 C8orf71 -0.6 -8.09 -0.41 1.16e-14 Developmental language disorder (linguistic errors); CRC cis rs4713118 0.824 rs7759217 chr6:27730463 A/G cg19041857 chr6:27730383 NA -0.46 -6.42 -0.33 4.87e-10 Parkinson's disease; CRC cis rs9291683 0.552 rs10939655 chr4:10014642 A/T cg00071950 chr4:10020882 SLC2A9 0.68 13.31 0.59 1.19e-32 Bone mineral density; CRC cis rs1215050 0.791 rs4699318 chr4:98664370 T/G cg05340658 chr4:99064831 C4orf37 -0.47 -7.01 -0.36 1.4e-11 Waist-to-hip ratio adjusted for body mass index; CRC cis rs995000 0.931 rs11207992 chr1:63041800 T/G cg19896129 chr1:63156450 NA 0.39 5.72 0.3 2.39e-8 Triglyceride levels; CRC cis rs6088580 0.634 rs6059856 chr20:33057954 G/C cg08999081 chr20:33150536 PIGU 0.61 11.3 0.53 3.09e-25 Glomerular filtration rate (creatinine); CRC cis rs6456156 0.586 rs6456150 chr6:167468922 A/G cg07741184 chr6:167504864 NA 0.39 6.85 0.35 3.64e-11 Primary biliary cholangitis; CRC cis rs1865760 0.613 rs2071300 chr6:25914572 C/T cg12310025 chr6:25882481 NA -0.45 -6.71 -0.35 8.44e-11 Height; CRC cis rs11628318 0.614 rs10132160 chr14:103058023 A/G cg08075719 chr14:103021372 NA -0.68 -7.94 -0.4 3.23e-14 Platelet count; CRC cis rs9903692 0.954 rs12941295 chr17:46188187 C/G cg21215337 chr17:46176117 CBX1 -0.41 -7.37 -0.38 1.38e-12 Pulse pressure; CRC cis rs2455601 0.638 rs3815991 chr11:9007669 A/G cg09997546 chr11:8931473 C11orf17;ST5 0.47 6.32 0.33 8.51e-10 Schizophrenia; CRC cis rs1018836 0.632 rs7002775 chr8:91476765 C/T cg16814680 chr8:91681699 NA 0.63 10.12 0.49 3.93e-21 Ejection fraction in Tripanosoma cruzi seropositivity; CRC trans rs2727020 0.595 rs10839286 chr11:49497063 C/A cg15704280 chr7:45808275 SEPT13 -0.95 -18.16 -0.71 1.58e-51 Coronary artery disease; CRC cis rs995000 0.931 rs11207969 chr1:62911751 A/G cg19896129 chr1:63156450 NA 0.42 6.31 0.33 8.8e-10 Triglyceride levels; CRC cis rs9527 0.590 rs7073323 chr10:104797423 A/C cg15744005 chr10:104629667 AS3MT -0.3 -6.03 -0.32 4.51e-9 Arsenic metabolism; CRC cis rs6860806 0.507 rs272868 chr5:131680751 C/G cg22638593 chr5:131593259 PDLIM4 0.38 6.33 0.33 8.14e-10 Breast cancer; CRC cis rs3733585 0.699 rs28613263 chr4:9964880 C/T cg00071950 chr4:10020882 SLC2A9 -0.54 -9.62 -0.47 1.81e-19 Cleft plate (environmental tobacco smoke interaction); CRC cis rs172166 0.694 rs203877 chr6:28048624 T/C cg26587870 chr6:27730563 NA -0.38 -5.86 -0.31 1.1e-8 Cardiac Troponin-T levels; CRC cis rs1009181 0.585 rs4486004 chr6:26167710 G/T cg13736514 chr6:26305472 NA -0.4 -5.85 -0.31 1.19e-8 Childhood ear infection; CRC cis rs9487051 0.676 rs6568566 chr6:109596792 G/A cg01475377 chr6:109611718 NA -0.37 -6.58 -0.34 1.85e-10 Reticulocyte fraction of red cells; CRC cis rs911555 0.723 rs11160751 chr14:103925740 T/C cg24130564 chr14:104152367 KLC1 -0.41 -5.77 -0.3 1.85e-8 Intelligence (multi-trait analysis); CRC cis rs10751667 0.643 rs10902257 chr11:973577 T/C ch.11.42038R chr11:967971 AP2A2 0.58 10.03 0.48 7.98e-21 Alzheimer's disease (late onset); CRC cis rs9322193 0.847 rs56103941 chr6:150137231 A/G cg00933542 chr6:150070202 PCMT1 0.3 5.78 0.3 1.78e-8 Lung cancer; CRC cis rs6570726 0.791 rs6923074 chr6:145893332 T/C cg05347473 chr6:146136440 FBXO30 0.38 5.85 0.31 1.18e-8 Lobe attachment (rater-scored or self-reported); CRC cis rs9399137 0.507 rs7754722 chr6:135260303 T/C cg22676075 chr6:135203613 NA -0.63 -9.37 -0.46 1.19e-18 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; CRC cis rs7927592 0.956 rs7126340 chr11:68257293 C/T cg16797656 chr11:68205561 LRP5 0.38 6.07 0.32 3.59e-9 Total body bone mineral density; CRC cis rs4665809 0.887 rs4665814 chr2:26273687 G/T cg25036284 chr2:26402008 FAM59B -0.44 -5.88 -0.31 1.02e-8 Gut microbiome composition (summer); CRC cis rs2243480 0.803 rs403089 chr7:65517723 T/C cg12463550 chr7:65579703 CRCP 0.75 6.82 0.35 4.5e-11 Diabetic kidney disease; CRC cis rs6952808 0.689 rs12670737 chr7:2046830 C/T cg02951883 chr7:2050386 MAD1L1 -0.75 -12.41 -0.56 2.77e-29 Bipolar disorder and schizophrenia; CRC trans rs2727020 0.658 rs4980442 chr11:49445016 G/T cg15704280 chr7:45808275 SEPT13 -0.91 -17.23 -0.69 7.4e-48 Coronary artery disease; CRC cis rs12142240 0.659 rs1984491 chr1:46858607 T/G cg00530320 chr1:46809349 NSUN4 0.59 8.07 0.41 1.35e-14 Menopause (age at onset); CRC cis rs2304069 0.507 rs7728264 chr5:149394954 C/G cg22760475 chr5:149380129 HMGXB3;TIGD6 0.45 6.6 0.34 1.62e-10 HIV-1 control; CRC cis rs7119 0.667 rs907393 chr15:77903447 T/C cg27398640 chr15:77910606 LINGO1 0.42 7.69 0.39 1.72e-13 Type 2 diabetes; CRC cis rs4713118 0.588 rs200994 chr6:27813813 A/C cg15845792 chr6:28175446 NA -0.75 -9.81 -0.48 4.35e-20 Parkinson's disease; CRC cis rs1552244 1.000 rs6786638 chr3:10118075 G/C cg00166722 chr3:10149974 C3orf24 0.7 9.53 0.46 3.69e-19 Alzheimer's disease; CRC cis rs1129187 0.967 rs3805952 chr6:42937126 C/T cg02353165 chr6:42928485 GNMT 0.85 15.48 0.65 5.3e-41 Alzheimer's disease in APOE e4+ carriers; CRC cis rs6942756 0.680 rs691555 chr7:129135770 C/T cg02491457 chr7:128862824 NA -0.49 -6.59 -0.34 1.8e-10 White matter hyperintensity burden; CRC cis rs597539 0.654 rs655816 chr11:68626405 A/G cg21963583 chr11:68658836 MRPL21 0.57 10.15 0.49 3.12e-21 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs6543140 0.964 rs13383602 chr2:103085962 C/T cg09003973 chr2:102972529 NA 0.41 5.86 0.31 1.12e-8 Blood protein levels; CRC cis rs7914558 0.966 rs12571568 chr10:104891396 C/G cg04362960 chr10:104952993 NT5C2 0.59 8.75 0.43 1.14e-16 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs6502050 0.835 rs4789677 chr17:80119842 A/G cg11859384 chr17:80120422 CCDC57 -0.36 -5.75 -0.3 2.06e-8 Life satisfaction; CRC cis rs4363385 0.765 rs3806221 chr1:153002555 G/T cg25856811 chr1:152973957 SPRR3 -0.26 -7.16 -0.37 5.44e-12 Inflammatory skin disease; CRC cis rs3820068 0.580 rs12747696 chr1:16002978 A/G cg27534772 chr1:16042836 PLEKHM2 0.56 10.93 0.52 6.07e-24 Systolic blood pressure; CRC cis rs9911578 0.900 rs717828 chr17:56535932 A/G cg12560992 chr17:57184187 TRIM37 0.9 16.15 0.66 1.36e-43 Intelligence (multi-trait analysis); CRC cis rs1534166 0.647 rs7355929 chr3:133514190 C/T cg27366882 chr3:133540807 NA -0.58 -8.72 -0.43 1.38e-16 Alcohol consumption (transferrin glycosylation); CRC cis rs138880 0.542 rs9616393 chr22:50314809 A/G cg22709217 chr22:50311962 ALG12;CRELD2 0.97 10.35 0.5 6.34e-22 Schizophrenia; CRC cis rs4716602 0.596 rs4490714 chr7:156162510 C/A cg16983916 chr7:156159713 NA -0.39 -6.72 -0.35 8.16e-11 Anti-saccade response; CRC cis rs798554 0.757 rs1182185 chr7:2872233 A/G cg19346786 chr7:2764209 NA -0.38 -6.78 -0.35 5.52e-11 Height; CRC cis rs2153535 0.542 rs9393012 chr6:8439809 G/A cg07606381 chr6:8435919 SLC35B3 0.68 10.89 0.51 8.99e-24 Motion sickness; CRC cis rs6942756 0.915 rs6946938 chr7:129004662 A/C cg02491457 chr7:128862824 NA -0.62 -8.35 -0.42 1.91e-15 White matter hyperintensity burden; CRC cis rs9828933 0.752 rs832192 chr3:63853423 T/C cg16258503 chr3:63850278 ATXN7;THOC7 0.83 8.44 0.42 1.04e-15 Type 2 diabetes; CRC cis rs1465370 0.682 rs7811409 chr7:130024701 G/C cg03229158 chr7:130009420 NA 0.44 6.22 0.32 1.48e-9 Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction);Waist circumference adjusted for BMI in active individuals;Waist circumference adjusted for body mass index; CRC cis rs35110281 0.667 rs4819287 chr21:45120147 A/G cg04455712 chr21:45112962 RRP1B 0.41 7.64 0.39 2.36e-13 Mean corpuscular volume; CRC cis rs2370759 1.000 rs2370759 chr10:32634972 G/A cg01819863 chr10:32635814 EPC1 1.14 13.38 0.59 6.6e-33 Sexual dysfunction (female); CRC cis rs2050392 0.517 rs602097 chr10:30747546 C/T cg25182066 chr10:30743637 MAP3K8 -0.62 -8.75 -0.43 1.12e-16 Inflammatory bowel disease; CRC cis rs1005277 0.579 rs1740747 chr10:38520465 G/A cg25517755 chr10:38738941 LOC399744 -0.41 -5.92 -0.31 8.23e-9 Extrinsic epigenetic age acceleration; CRC cis rs7647973 1.000 rs2177268 chr3:49439725 A/T cg20833759 chr3:49053208 WDR6;DALRD3 -0.55 -8.2 -0.41 5.38e-15 Menarche (age at onset); CRC cis rs1712517 0.771 rs61350103 chr10:105069120 A/C cg05636881 chr10:105038444 INA 0.45 7.84 0.4 6.27e-14 Migraine; CRC cis rs4888262 0.526 rs6564142 chr16:74590047 T/C cg01733217 chr16:74700730 RFWD3 0.74 11.12 0.52 1.32e-24 Testicular germ cell tumor; CRC cis rs9322193 0.923 rs11155670 chr6:149966128 C/G cg13206674 chr6:150067644 NUP43 0.68 10.12 0.49 3.74e-21 Lung cancer; CRC cis rs1862618 0.671 rs2591957 chr5:56243146 A/T cg24531977 chr5:56204891 C5orf35 0.66 10.23 0.49 1.61e-21 Initial pursuit acceleration; CRC cis rs7107174 1.000 rs12277648 chr11:78054336 C/T cg02023728 chr11:77925099 USP35 0.5 8.85 0.44 5.45e-17 Testicular germ cell tumor; CRC cis rs225245 0.694 rs321616 chr17:33882720 C/T cg05299278 chr17:33885742 SLFN14 0.45 7.29 0.37 2.27e-12 Reticulocyte count;Reticulocyte fraction of red cells;High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells; CRC cis rs9911578 1.000 rs9807057 chr17:56889952 A/C cg05425664 chr17:57184151 TRIM37 -0.48 -7.57 -0.38 3.89e-13 Intelligence (multi-trait analysis); CRC cis rs3540 0.576 rs1974519 chr15:91036460 A/G cg22089800 chr15:90895588 ZNF774 0.55 8.95 0.44 2.61e-17 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; CRC cis rs3772130 0.962 rs1920320 chr3:121547527 A/G cg20356878 chr3:121714668 ILDR1 0.52 8.05 0.41 1.49e-14 Cognitive performance; CRC cis rs10504229 0.679 rs11781858 chr8:58038406 C/T cg24829409 chr8:58192753 C8orf71 -0.61 -7.48 -0.38 6.81e-13 Developmental language disorder (linguistic errors); CRC trans rs66573146 0.831 rs11546450 chr4:7032180 G/A cg07817883 chr1:32538562 TMEM39B 1.23 11.25 0.53 4.71e-25 Granulocyte percentage of myeloid white cells; CRC cis rs7937682 0.961 rs491937 chr11:111494947 A/T cg19812747 chr11:111475976 SIK2 -0.56 -9.61 -0.47 1.9e-19 Primary sclerosing cholangitis; CRC cis rs4713118 0.911 rs9295746 chr6:27730064 T/C cg12273811 chr6:28175739 NA 0.54 6.63 0.34 1.35e-10 Parkinson's disease; CRC cis rs7811142 0.943 rs66958101 chr7:100074020 G/A cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.14 16.65 0.68 1.43e-45 Platelet count; CRC cis rs9826463 0.582 rs73238145 chr3:142060559 G/A cg20824294 chr3:142316082 PLS1 0.35 5.7 0.3 2.72e-8 QRS duration in Tripanosoma cruzi seropositivity; CRC cis rs9916302 0.706 rs12950186 chr17:37393395 A/C cg07936489 chr17:37558343 FBXL20 -0.86 -10.61 -0.5 8.32e-23 Glomerular filtration rate (creatinine); CRC cis rs11098499 0.865 rs10032158 chr4:120391632 C/T cg09307838 chr4:120376055 NA 0.7 10.83 0.51 1.42e-23 Corneal astigmatism; CRC cis rs6815814 0.950 rs56408159 chr4:38812116 T/A cg06935464 chr4:38784597 TLR10 0.55 5.74 0.3 2.12e-8 Breast cancer; CRC cis rs4727027 0.834 rs7811446 chr7:148773226 G/T cg23583168 chr7:148888333 NA -0.88 -14.96 -0.64 5.9e-39 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC cis rs8062405 0.754 rs149299 chr16:28485141 T/C cg16576597 chr16:28551801 NUPR1 0.43 5.86 0.31 1.11e-8 Cognitive ability (multi-trait analysis);Cognitive ability; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg05863534 chr17:34948351 DHRS11 0.37 5.97 0.31 6.06e-9 Liver disease severity in Alagille syndrome; CRC cis rs7113874 0.589 rs7120065 chr11:8484896 C/T cg02811074 chr11:8615871 STK33 -0.36 -6.15 -0.32 2.24e-9 Body mass index in physically active individuals;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs2153535 0.580 rs7453115 chr6:8447261 A/G cg21535247 chr6:8435926 SLC35B3 0.5 7.56 0.38 4.18e-13 Motion sickness; CRC cis rs10540 1.000 rs12418639 chr11:473300 A/C cg03576123 chr11:487126 PTDSS2 1.02 10.48 0.5 2.23e-22 Body mass index; CRC cis rs9549328 0.614 rs35872678 chr13:113617231 A/T cg08614441 chr13:113633676 MCF2L 0.4 7.08 0.36 8.63e-12 Systolic blood pressure; CRC cis rs2204008 0.774 rs11180977 chr12:38263094 G/T cg26384229 chr12:38710491 ALG10B 0.69 9.22 0.45 3.69e-18 Bladder cancer; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg04738379 chr15:81282102 MESDC2 0.4 6.3 0.33 9.28e-10 Liver disease severity in Alagille syndrome; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg05735659 chr12:48099394 RPAP3 -0.46 -7.04 -0.36 1.15e-11 Liver disease severity in Alagille syndrome; CRC cis rs4972806 0.849 rs1542180 chr2:177028767 C/T cg09355771 chr2:177043147 NA 0.65 9.66 0.47 1.36e-19 IgG glycosylation; CRC cis rs1577917 0.958 rs10944147 chr6:86550786 C/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.53 -6.61 -0.34 1.6e-10 Response to antipsychotic treatment; CRC cis rs12956009 0.518 rs10163861 chr18:44820214 A/G cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.37 5.66 0.3 3.28e-8 Educational attainment (years of education); CRC cis rs2073499 0.935 rs57838764 chr3:50374568 T/C cg09545109 chr3:50388910 TUSC4;CYB561D2 0.59 6.39 0.33 5.54e-10 Schizophrenia; CRC cis rs9911578 0.967 rs4598970 chr17:57076893 T/A cg12560992 chr17:57184187 TRIM37 -0.94 -16.63 -0.68 1.71e-45 Intelligence (multi-trait analysis); CRC cis rs4804416 0.779 rs62112763 chr19:7220013 C/G cg09779027 chr19:7224513 INSR 0.62 9.45 0.46 6.5e-19 Thyroid hormone levels;Hypothyroidism; CRC cis rs10979 1.000 rs9484768 chr6:143887928 C/T cg25407410 chr6:143891975 LOC285740 -0.82 -13.41 -0.59 5.06e-33 Hypospadias; CRC cis rs2522056 1.000 rs10900807 chr5:131757480 G/C cg24060327 chr5:131705240 SLC22A5 0.47 6.36 0.33 6.8e-10 Lymphocyte counts;Fibrinogen; CRC trans rs11148252 0.875 rs9596651 chr13:52938582 A/G cg18335740 chr13:41363409 SLC25A15 -0.5 -7.84 -0.4 6.12e-14 Lewy body disease; CRC cis rs2032447 1.000 rs2032447 chr6:26044369 A/G cg12310025 chr6:25882481 NA -0.44 -6.23 -0.32 1.45e-9 Intelligence (multi-trait analysis); CRC cis rs17001868 0.568 rs73167007 chr22:40734241 G/C cg07138101 chr22:40742427 ADSL 0.6 7.82 0.4 7.06e-14 Mammographic density (dense area); CRC cis rs3733585 0.673 rs4697914 chr4:9952266 G/A cg00071950 chr4:10020882 SLC2A9 -0.55 -9.74 -0.47 7.09e-20 Cleft plate (environmental tobacco smoke interaction); CRC cis rs6499255 1.000 rs1139178 chr16:69781468 T/C cg15192750 chr16:69999425 NA 0.55 7.17 0.37 4.99e-12 IgE levels; CRC cis rs2404602 0.692 rs4886503 chr15:77108874 C/T cg23625390 chr15:77176239 SCAPER -0.47 -6.82 -0.35 4.36e-11 Blood metabolite levels; CRC cis rs10504229 0.595 rs116490935 chr8:58117531 A/G cg24829409 chr8:58192753 C8orf71 -0.54 -7.82 -0.4 7.48e-14 Developmental language disorder (linguistic errors); CRC cis rs1862618 0.853 rs6450408 chr5:56098146 T/C cg03609598 chr5:56110824 MAP3K1 -0.83 -10.03 -0.48 7.79e-21 Initial pursuit acceleration; CRC cis rs7666738 0.791 rs1426674 chr4:98924247 C/A cg05340658 chr4:99064831 C4orf37 0.6 9.35 0.46 1.41e-18 Colonoscopy-negative controls vs population controls; CRC cis rs10979 0.597 rs9403515 chr6:143908013 A/G cg25407410 chr6:143891975 LOC285740 -0.62 -8.31 -0.42 2.53e-15 Hypospadias; CRC cis rs1784581 0.588 rs9295180 chr6:162420579 T/C cg17173639 chr6:162384350 PARK2 0.6 9.71 0.47 9.23e-20 Itch intensity from mosquito bite; CRC cis rs1862618 0.756 rs9292125 chr5:56107200 C/T cg12311346 chr5:56204834 C5orf35 -0.8 -10.63 -0.51 7.24e-23 Initial pursuit acceleration; CRC trans rs2228479 0.702 rs17177891 chr16:89799950 C/T cg21302420 chr1:112162376 RAP1A 0.72 5.96 0.31 6.55e-9 Skin colour saturation; CRC cis rs2576037 0.523 rs1539881 chr18:44477897 C/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.63 10.96 0.52 5.04e-24 Personality dimensions; CRC cis rs6541297 0.941 rs2180078 chr1:230280513 T/C cg05784532 chr1:230284198 GALNT2 0.48 6.54 0.34 2.4e-10 Coronary artery disease; CRC cis rs1153858 1.000 rs4625670 chr15:45652926 C/T cg10760299 chr15:45669010 GATM 0.51 8.27 0.41 3.46e-15 Homoarginine levels; CRC cis rs2732480 0.500 rs2932093 chr12:48648271 G/T cg24011408 chr12:48396354 COL2A1 0.46 6.37 0.33 6.28e-10 Hemoglobin concentration;Red blood cell count;Hematocrit; CRC cis rs1949733 1.000 rs3103071 chr4:8508579 C/G cg13073564 chr4:8508604 NA 0.49 7.32 0.37 1.94e-12 Response to antineoplastic agents; CRC trans rs9926664 1.000 rs11646550 chr16:85938835 C/T cg03946896 chr1:44871606 RNF220 -0.66 -6.2 -0.32 1.68e-9 Sum basophil neutrophil counts;Neutrophil count; CRC cis rs6502050 0.835 rs34287733 chr17:80078236 C/T cg22110888 chr17:80059540 CCDC57 -0.41 -6.39 -0.33 5.66e-10 Life satisfaction; CRC cis rs2153535 0.546 rs9378559 chr6:8539058 A/T cg07606381 chr6:8435919 SLC35B3 0.68 11.07 0.52 1.99e-24 Motion sickness; CRC cis rs10046574 0.519 rs11505985 chr7:135210197 G/T cg27474649 chr7:135195673 CNOT4 0.61 5.95 0.31 7.03e-9 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs863345 0.604 rs10908653 chr1:158455353 A/G cg12129480 chr1:158549410 OR10X1 -0.29 -6.05 -0.32 3.87e-9 Pneumococcal bacteremia; CRC cis rs12594515 1.000 rs12594515 chr15:45985071 C/G cg06207120 chr15:45996521 NA -0.32 -7.65 -0.39 2.22e-13 Waist circumference;Weight; CRC cis rs7412746 0.611 rs66847267 chr1:150875173 C/A cg10589385 chr1:150898437 SETDB1 0.28 6.07 0.32 3.43e-9 Melanoma; CRC cis rs7044106 0.762 rs1547267 chr9:123408736 T/C cg09419670 chr9:123605666 PSMD5;LOC253039 0.7 10.68 0.51 4.84e-23 Hip circumference adjusted for BMI; CRC cis rs7258465 1.000 rs10164323 chr19:18569492 C/T cg06462663 chr19:18546047 ISYNA1 0.48 7.36 0.38 1.45e-12 Breast cancer; CRC cis rs9534288 0.731 rs4942461 chr13:46551023 C/T cg15192986 chr13:46630673 CPB2 -0.67 -9.86 -0.48 2.81e-20 Blood protein levels; CRC cis rs9611519 0.929 rs73174657 chr22:41434158 G/A cg03806693 chr22:41940476 POLR3H -0.58 -7.33 -0.37 1.84e-12 Neuroticism; CRC cis rs12410462 0.901 rs79626242 chr1:227650385 A/G cg04117972 chr1:227635322 NA 0.67 7.6 0.39 3.08e-13 Major depressive disorder; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg18222961 chr2:48009935 MSH6 -0.46 -6.83 -0.35 4.21e-11 Myopia (pathological); CRC trans rs2303319 0.504 rs56026147 chr2:162614089 T/C cg22677401 chr17:46026860 NA -0.67 -6.07 -0.32 3.57e-9 Cognitive function; CRC cis rs4466137 0.794 rs6869296 chr5:83007333 C/G cg12199221 chr5:83017078 HAPLN1 0.33 5.79 0.3 1.65e-8 Prostate cancer; CRC cis rs11864453 0.928 rs3213420 chr16:72042433 C/T cg23815491 chr16:72088622 HP 0.56 8.54 0.43 5.02e-16 Fibrinogen levels; CRC cis rs7772486 0.720 rs4896837 chr6:146014168 C/T cg23711669 chr6:146136114 FBXO30 -0.75 -12.76 -0.58 1.43e-30 Lobe attachment (rater-scored or self-reported); CRC cis rs13108904 0.837 rs4519749 chr4:1280102 A/G cg05665937 chr4:1216051 CTBP1 0.4 5.75 0.3 1.99e-8 Obesity-related traits; CRC cis rs711830 1.000 rs2113559 chr2:177031099 A/G cg13092806 chr2:177043255 NA 0.72 8.56 0.43 4.4e-16 Serous invasive ovarian cancer;Epithelial ovarian cancer;Invasive epithelial ovarian cancer;Mucinous ovarian carcinoma;Low-grade serous and serous borderline ovarian cancer;Serous borderline ovarian cancer;High-grade serous ovarian cancer; CRC cis rs6582630 0.585 rs12422588 chr12:38478675 C/T cg13010199 chr12:38710504 ALG10B -0.41 -5.89 -0.31 9.38e-9 Drug-induced liver injury (flucloxacillin); CRC cis rs6679356 0.789 rs11209051 chr1:67798895 C/T cg24364144 chr1:67875067 SERBP1 0.41 5.79 0.3 1.63e-8 Primary biliary cholangitis; CRC cis rs854765 0.547 rs4584886 chr17:17896205 C/T cg07919128 chr17:18022025 MYO15A -0.39 -6.82 -0.35 4.48e-11 Total body bone mineral density; CRC cis rs1008375 0.966 rs6833808 chr4:17652526 T/A cg16339924 chr4:17578868 LAP3 0.55 7.28 0.37 2.41e-12 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs7274811 0.681 rs186026 chr20:31951993 G/T cg03904042 chr20:32255491 NECAB3;C20orf134 0.4 5.74 0.3 2.18e-8 Height; CRC cis rs1552244 0.882 rs56332224 chr3:10037321 G/A cg18598329 chr3:10140678 FANCD2;C3orf24 -0.81 -10.65 -0.51 5.88e-23 Alzheimer's disease; CRC cis rs10540 0.908 rs35608427 chr11:498976 T/C cg08200582 chr11:442649 ANO9 -0.69 -7.19 -0.37 4.32e-12 Body mass index; CRC trans rs360798 0.512 rs2430388 chr2:63106784 T/C cg05376469 chr2:102649931 NA -0.37 -6.01 -0.31 4.92e-9 Coronary artery disease; CRC cis rs17767392 0.958 rs117821900 chr14:71985670 A/T cg13720639 chr14:72061746 SIPA1L1 -0.49 -6.4 -0.33 5.28e-10 Mitral valve prolapse; CRC cis rs1401999 1.000 rs1401999 chr3:183678342 C/G cg20387954 chr3:183756860 HTR3D 0.46 7.76 0.39 1.1e-13 Anterior chamber depth; CRC cis rs4713118 0.869 rs9461400 chr6:27700559 A/G cg26587870 chr6:27730563 NA -0.43 -6.72 -0.35 8.04e-11 Parkinson's disease; CRC cis rs7945705 0.967 rs10840141 chr11:8902218 T/C cg14711859 chr11:8959438 ASCL3 -0.49 -8.08 -0.41 1.26e-14 Hemoglobin concentration; CRC cis rs739401 0.572 rs12276060 chr11:3015572 A/T cg05729581 chr11:3078854 CARS -0.57 -8.41 -0.42 1.3e-15 Longevity; CRC cis rs4731207 0.596 rs6956910 chr7:124642364 A/C cg23710748 chr7:124431027 NA -0.43 -6.86 -0.35 3.42e-11 Cutaneous malignant melanoma; CRC cis rs2153535 0.601 rs2143352 chr6:8530248 G/C cg07606381 chr6:8435919 SLC35B3 0.67 10.86 0.51 1.14e-23 Motion sickness; CRC cis rs60843830 1.000 rs60484953 chr2:221560 G/A cg00108164 chr2:264199 ACP1;SH3YL1 0.63 9.71 0.47 9.1e-20 Spherical equivalent (joint analysis main effects and education interaction); CRC cis rs8077889 0.719 rs2079006 chr17:41865745 C/G cg26893861 chr17:41843967 DUSP3 1.08 20.71 0.75 1.42e-61 Triglycerides; CRC cis rs7727544 0.654 rs4705849 chr5:131559199 T/A cg04518342 chr5:131593106 PDLIM4 0.37 6.77 0.35 5.89e-11 Blood metabolite levels; CRC cis rs11864453 0.713 rs7191127 chr16:72123992 G/T cg01557791 chr16:72042693 DHODH -0.44 -6.14 -0.32 2.36e-9 Fibrinogen levels; CRC cis rs9733 0.596 rs1415148 chr1:150705755 G/A cg10589385 chr1:150898437 SETDB1 0.28 5.74 0.3 2.19e-8 Tonsillectomy; CRC cis rs5769765 0.908 rs9616396 chr22:50317825 T/C cg22709217 chr22:50311962 ALG12;CRELD2 -1.05 -15.41 -0.65 1.03e-40 Schizophrenia; CRC cis rs7618501 0.633 rs7628058 chr3:50039474 C/T cg24308560 chr3:49941425 MST1R -0.52 -8.49 -0.42 7.08e-16 Intelligence (multi-trait analysis); CRC cis rs722599 0.748 rs1059326 chr14:75369385 C/T cg08847533 chr14:75593920 NEK9 -0.43 -5.82 -0.31 1.4e-8 IgG glycosylation; CRC cis rs4713118 0.662 rs9468271 chr6:28024570 A/G cg12172441 chr6:28176163 NA 0.56 7.16 0.37 5.25e-12 Parkinson's disease; CRC cis rs17376456 0.542 rs1982439 chr5:93160560 C/G cg25358565 chr5:93447407 FAM172A -0.62 -7.43 -0.38 9.74e-13 Diabetic retinopathy; CRC cis rs3996993 0.809 rs4535545 chr6:52694033 C/T cg20803780 chr6:52668592 GSTA1 -0.39 -7.28 -0.37 2.49e-12 Hemoglobin concentration; CRC cis rs12134245 0.776 rs625525 chr1:91997593 C/T cg02896835 chr1:92012615 NA -0.69 -13.02 -0.58 1.55e-31 Breast cancer; CRC cis rs9649213 0.593 rs6949214 chr7:97960233 G/A cg24562669 chr7:97807699 LMTK2 0.44 7.29 0.37 2.33e-12 Prostate cancer (SNP x SNP interaction); CRC cis rs6701037 0.681 rs2285220 chr1:175130773 T/A cg00321850 chr1:175162397 KIAA0040 -0.41 -6.69 -0.35 9.41e-11 Alcohol dependence; CRC cis rs1355223 0.583 rs1828298 chr11:34870439 A/G cg11058730 chr11:34937778 PDHX;APIP 0.71 11.55 0.54 3.78e-26 Systemic lupus erythematosus and Systemic sclerosis; CRC cis rs79387448 0.745 rs1523197 chr2:103163732 A/G cg00507830 chr2:103233733 NA 0.51 5.61 0.3 4.25e-8 Gut microbiota (bacterial taxa); CRC cis rs2739330 0.760 rs1007888 chr22:24241101 C/T cg11905131 chr22:24372483 LOC391322 -0.65 -10.12 -0.49 4.01e-21 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs9733 0.596 rs72702536 chr1:150662574 C/T cg10589385 chr1:150898437 SETDB1 0.29 6.13 0.32 2.58e-9 Tonsillectomy; CRC cis rs79349575 0.756 rs937301 chr17:47046276 A/G cg22482690 chr17:47019901 SNF8 -0.5 -8.27 -0.41 3.33e-15 Type 2 diabetes; CRC cis rs9488822 0.651 rs3798228 chr6:116321156 T/C cg15226275 chr6:116381976 FRK 0.3 8.5 0.42 6.55e-16 Cholesterol, total;LDL cholesterol; CRC cis rs68170813 0.559 rs12534676 chr7:106943640 G/A cg02696742 chr7:106810147 HBP1 -0.57 -6.32 -0.33 8.44e-10 Coronary artery disease; CRC cis rs6964587 0.839 rs62466159 chr7:91450507 A/G cg17063962 chr7:91808500 NA 0.67 10.72 0.51 3.47e-23 Breast cancer; CRC cis rs2952156 0.920 rs732084 chr17:37834357 A/C cg00129232 chr17:37814104 STARD3 -0.68 -11.83 -0.55 3.88e-27 Asthma; CRC cis rs4713118 0.824 rs2179095 chr6:27750858 A/G cg15845792 chr6:28175446 NA -0.66 -8.62 -0.43 2.84e-16 Parkinson's disease; CRC cis rs708547 0.599 rs2948348 chr4:57848772 G/A cg25525207 chr4:57843836 C4orf14;POLR2B -0.5 -7.44 -0.38 8.68e-13 Response to bleomycin (chromatid breaks); CRC cis rs72945132 0.941 rs66803755 chr11:70117473 G/A cg14191688 chr11:70257035 CTTN 0.48 6.2 0.32 1.71e-9 Coronary artery disease; CRC cis rs7264396 0.580 rs6060648 chr20:34456704 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.59 -8.51 -0.42 6.27e-16 Total cholesterol levels; CRC cis rs524281 0.814 rs10896098 chr11:65968416 G/A cg16950941 chr11:66035639 RAB1B -0.61 -7.57 -0.39 3.88e-13 Electroencephalogram traits; CRC cis rs1552244 0.935 rs7621551 chr3:10114205 C/T cg00166722 chr3:10149974 C3orf24 0.7 9.53 0.46 3.69e-19 Alzheimer's disease; CRC cis rs11645898 0.748 rs72791120 chr16:72224583 G/T cg14768367 chr16:72042858 DHODH -0.61 -6.86 -0.35 3.37e-11 Blood protein levels; CRC cis rs875971 0.964 rs12668936 chr7:65914404 C/T cg18912574 chr7:65842487 NCRNA00174 0.35 6.04 0.32 4.24e-9 Aortic root size; CRC cis rs7552404 1.000 rs6593585 chr1:76140273 G/A cg10523679 chr1:76189770 ACADM 0.83 11.5 0.54 6.08e-26 Blood metabolite levels;Acylcarnitine levels; CRC cis rs9814567 1.000 rs13089966 chr3:134279197 A/G cg06109529 chr3:134205091 CEP63;ANAPC13 0.82 12.06 0.55 5.69e-28 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs9649213 0.511 rs6950994 chr7:97887872 G/A cg24562669 chr7:97807699 LMTK2 0.51 8.5 0.42 6.59e-16 Prostate cancer (SNP x SNP interaction); CRC cis rs524281 0.861 rs10750780 chr11:65974592 G/A cg16950941 chr11:66035639 RAB1B -0.62 -7.39 -0.38 1.23e-12 Electroencephalogram traits; CRC cis rs4862750 0.832 rs10007858 chr4:187877492 A/G cg07414643 chr4:187882934 NA 0.38 6.7 0.35 8.91e-11 Lobe attachment (rater-scored or self-reported); CRC cis rs1003719 0.788 rs2835597 chr21:38466539 C/T cg10648535 chr21:38446584 PIGP;TTC3 0.52 7.41 0.38 1.07e-12 Eye color traits; CRC cis rs7923609 0.870 rs10822156 chr10:65080727 T/C cg08743896 chr10:65200160 JMJD1C -0.4 -5.71 -0.3 2.54e-8 Educational attainment;Liver enzyme levels (alkaline phosphatase); CRC cis rs4805272 0.626 rs6509072 chr19:29331703 C/G cg12667521 chr19:29218732 NA 0.44 6.51 0.34 2.76e-10 Plasma omega-3 polyunsaturated fatty acid levels (docosahexaenoic acid); CRC cis rs7223966 1.000 rs6504173 chr17:61735056 T/C cg23903597 chr17:61704154 MAP3K3 -0.42 -5.83 -0.31 1.36e-8 Hip circumference adjusted for BMI;Body mass index; CRC cis rs875971 0.789 rs28815324 chr7:65565776 A/T cg03233332 chr7:66118400 NA 0.45 6.22 0.32 1.55e-9 Aortic root size; CRC cis rs875971 0.895 rs12698520 chr7:65918707 C/A cg00343986 chr7:65444356 GUSB 0.43 6.28 0.33 1.08e-9 Aortic root size; CRC cis rs853679 0.550 rs1233707 chr6:28172953 G/A cg02683197 chr6:28174875 NA 0.87 12.16 0.56 2.47e-28 Depression; CRC cis rs7412746 0.658 rs11589458 chr1:150792616 A/G cg10589385 chr1:150898437 SETDB1 0.32 6.54 0.34 2.42e-10 Melanoma; CRC cis rs7618501 0.521 rs6774354 chr3:49961780 G/A cg24110177 chr3:50126178 RBM5 -0.6 -9.31 -0.46 1.85e-18 Intelligence (multi-trait analysis); CRC cis rs6570726 0.599 rs9403725 chr6:145897622 A/T cg23711669 chr6:146136114 FBXO30 -0.62 -9.19 -0.45 4.48e-18 Lobe attachment (rater-scored or self-reported); CRC cis rs1218582 0.772 rs4845400 chr1:154872523 C/T cg03351412 chr1:154909251 PMVK 0.54 8.69 0.43 1.78e-16 Prostate cancer; CRC cis rs172166 0.637 rs1233708 chr6:28173219 C/T cg12273811 chr6:28175739 NA 0.63 9.42 0.46 8.17e-19 Cardiac Troponin-T levels; CRC cis rs977987 0.898 rs12918797 chr16:75493810 T/C cg03315344 chr16:75512273 CHST6 0.6 10.19 0.49 2.21e-21 Dupuytren's disease; CRC cis rs9611565 0.649 rs5751108 chr22:41858035 T/C cg06634786 chr22:41940651 POLR3H 0.63 7.24 0.37 3.18e-12 Vitiligo; CRC cis rs59104589 0.617 rs60132543 chr2:242344599 T/C cg19488206 chr2:242435732 STK25 0.43 6.33 0.33 7.84e-10 Fibrinogen levels; CRC cis rs35264875 1.000 rs72928644 chr11:68849845 A/G cg15234197 chr11:68924956 NA 0.44 6.12 0.32 2.72e-9 Blond vs. brown hair color; CRC cis rs4555082 0.874 rs2816625 chr14:105734565 G/A cg06808227 chr14:105710500 BRF1 -0.62 -8.75 -0.43 1.16e-16 Mean platelet volume;Platelet distribution width; CRC cis rs847649 0.842 rs11976237 chr7:102641383 A/G cg18108683 chr7:102477205 FBXL13 0.56 8.97 0.44 2.3e-17 Morning vs. evening chronotype; CRC cis rs6570726 0.967 rs6903252 chr6:145922777 A/G cg23711669 chr6:146136114 FBXO30 0.68 11.36 0.53 1.9e-25 Lobe attachment (rater-scored or self-reported); CRC cis rs1707322 0.928 rs7527244 chr1:46368772 A/G cg06784218 chr1:46089804 CCDC17 0.52 9.09 0.45 9.47e-18 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs7949030 0.626 rs7124057 chr11:62334096 A/G cg11742103 chr11:62369870 EML3;MTA2 0.62 11.85 0.55 3.28e-27 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; CRC cis rs6912958 0.703 rs9362427 chr6:88097634 G/T cg12350822 chr6:88032061 C6orf162;GJB7 0.47 9.32 0.46 1.78e-18 Monocyte percentage of white cells; CRC cis rs6429082 0.902 rs704708 chr1:235620134 T/C cg26050004 chr1:235667680 B3GALNT2 0.4 6.01 0.31 4.94e-9 Adiposity; CRC cis rs9486719 1.000 rs12208449 chr6:96903253 A/G cg18709589 chr6:96969512 KIAA0776 0.51 5.72 0.3 2.43e-8 Migraine;Coronary artery disease; CRC cis rs9309473 0.607 rs6546826 chr2:73599808 A/G cg20560298 chr2:73613845 ALMS1 0.5 7.01 0.36 1.37e-11 Metabolite levels; CRC cis rs4561483 0.583 rs11075032 chr16:12004450 C/T cg08843971 chr16:11963173 GSPT1 0.5 7.46 0.38 7.59e-13 Testicular germ cell tumor; CRC cis rs11039389 1 rs11039389 chr11:47796062 T/C cg18512352 chr11:47633146 NA -0.49 -9.41 -0.46 8.89e-19 Neuroticism; CRC cis rs863345 0.527 rs10797019 chr1:158490221 A/T cg12129480 chr1:158549410 OR10X1 -0.3 -6.25 -0.33 1.25e-9 Pneumococcal bacteremia; CRC trans rs1864729 1.000 rs1431891 chr8:98282716 A/G cg08679828 chr8:102218111 ZNF706 -0.63 -7.54 -0.38 4.76e-13 Estradiol plasma levels (breast cancer); CRC cis rs2075371 0.933 rs1421481 chr7:133964380 A/C cg20476274 chr7:133979776 SLC35B4 0.78 14.1 0.61 1.17e-35 Mean platelet volume; CRC cis rs1109861 0.535 rs752379 chr10:11244600 G/A cg24910943 chr10:11206320 CUGBP2 -0.28 -6.92 -0.36 2.42e-11 Urinary albumin-to-creatinine ratio; CRC cis rs7267979 0.727 rs4815431 chr20:25532405 T/C cg24626310 chr20:25276739 ABHD12;PYGB -0.33 -5.68 -0.3 3.02e-8 Liver enzyme levels (alkaline phosphatase); CRC cis rs7707921 0.767 rs862242 chr5:81587566 C/T cg07807695 chr5:81608485 ATP6AP1L 0.46 7.34 0.38 1.69e-12 Breast cancer; CRC cis rs9858542 1.000 rs11709525 chr3:49690496 C/T cg00383909 chr3:49044727 WDR6 0.46 5.76 0.3 1.98e-8 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs921968 0.541 rs634590 chr2:219372768 C/A cg02176678 chr2:219576539 TTLL4 0.54 8.69 0.43 1.78e-16 Mean corpuscular hemoglobin concentration; CRC cis rs67311347 1.000 rs9849992 chr3:40402140 C/T cg24209194 chr3:40518798 ZNF619 0.38 5.66 0.3 3.28e-8 Renal cell carcinoma; CRC cis rs3540 0.960 rs4031435 chr15:91015566 G/C cg04176472 chr15:90893244 GABARAPL3 0.35 6.03 0.32 4.46e-9 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; CRC cis rs17767392 1.000 rs35260692 chr14:71831665 T/C cg13720639 chr14:72061746 SIPA1L1 -0.54 -6.77 -0.35 5.81e-11 Mitral valve prolapse; CRC cis rs1639906 1.000 rs1637759 chr7:2220053 C/T cg19897017 chr7:2163380 MAD1L1 0.41 6.37 0.33 6.32e-10 Colonoscopy-negative controls vs population controls; CRC cis rs7618915 0.547 rs10780035 chr3:52764624 C/T cg10802521 chr3:52805072 NEK4 -0.57 -8.77 -0.44 1.01e-16 Bipolar disorder; CRC cis rs929596 0.785 rs6714634 chr2:234664765 C/T cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 0.7 10.02 0.48 8.47e-21 Total bilirubin levels in HIV-1 infection; CRC cis rs4474465 0.646 rs10793334 chr11:78278792 C/T cg27205649 chr11:78285834 NARS2 -0.54 -7.28 -0.37 2.42e-12 Alzheimer's disease (survival time); CRC cis rs8060686 0.858 rs7196789 chr16:67927124 C/T cg07125278 chr16:67683757 RLTPR -0.5 -6.91 -0.36 2.58e-11 HDL cholesterol;Metabolic syndrome; CRC cis rs2976388 0.647 rs2585138 chr8:143808951 C/T cg15511327 chr8:143859410 LYNX1 0.41 7.22 0.37 3.73e-12 Urinary tract infection frequency; CRC trans rs12714314 0.560 rs11694545 chr2:1939208 C/T cg19998675 chr3:182970903 MCF2L2;B3GNT5 0.44 6.18 0.32 1.92e-9 Type 2 diabetes (age of onset); CRC cis rs9942416 0.601 rs40059 chr5:74964582 A/G cg19683494 chr5:74908142 NA -0.47 -6.17 -0.32 1.95e-9 Age-related disease endophenotypes; CRC trans rs7944735 0.517 rs74763661 chr11:48233772 T/C cg03929089 chr4:120376271 NA 0.69 6.81 0.35 4.7e-11 Intraocular pressure; CRC cis rs11229555 0.645 rs12786744 chr11:58177549 T/C cg15696309 chr11:58395628 NA -0.9 -11.56 -0.54 3.5e-26 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; CRC cis rs1862618 0.853 rs832551 chr5:56180112 T/G cg03609598 chr5:56110824 MAP3K1 -0.85 -10.06 -0.49 6.18e-21 Initial pursuit acceleration; CRC cis rs10206020 0.797 rs72778008 chr2:1573182 T/G cg26248373 chr2:1572462 NA -0.86 -12.69 -0.57 2.63e-30 IgG glycosylation; CRC cis rs1322512 0.959 rs1727053 chr6:152947596 A/G cg03415253 chr6:152958462 SYNE1 -0.42 -6.41 -0.33 5.09e-10 Tonometry; CRC cis rs9486719 1.000 rs2971608 chr6:97039757 T/C cg06623918 chr6:96969491 KIAA0776 -0.84 -12.19 -0.56 1.81e-28 Migraine;Coronary artery disease; CRC cis rs7043114 0.507 rs6479420 chr9:95116406 T/C cg14631576 chr9:95140430 CENPP -0.31 -5.84 -0.31 1.22e-8 Height; CRC cis rs9747201 0.889 rs4789784 chr17:80179213 G/A cg09264619 chr17:80180166 NA -0.49 -6.87 -0.35 3.28e-11 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs9372498 0.536 rs55697388 chr6:118891544 C/T cg07617317 chr6:118971624 C6orf204 0.5 6.13 0.32 2.57e-9 Diastolic blood pressure; CRC cis rs9660992 0.573 rs12126439 chr1:205200720 C/T cg21643547 chr1:205240462 TMCC2 -0.38 -6.08 -0.32 3.27e-9 Mean corpuscular volume;Mean platelet volume; CRC cis rs2976388 0.609 rs2717602 chr8:143805683 G/A cg24046110 chr8:143859143 LYNX1 0.47 8.04 0.41 1.64e-14 Urinary tract infection frequency; CRC cis rs2257205 0.588 rs7209327 chr17:56741834 A/G cg25885038 chr17:56607967 SEPT4 -0.52 -5.69 -0.3 2.87e-8 Pancreatic cancer; CRC cis rs7618915 0.547 rs34610142 chr3:52708429 G/A cg18099408 chr3:52552593 STAB1 -0.44 -7.16 -0.37 5.27e-12 Bipolar disorder; CRC cis rs7113874 0.589 rs11041944 chr11:8500996 G/A cg20771178 chr11:8615675 STK33 0.35 5.75 0.3 2e-8 Body mass index in physically active individuals;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs12900413 0.959 rs11632886 chr15:90322945 A/G cg24249390 chr15:90295951 MESP1 -0.62 -9.32 -0.46 1.72e-18 Coronary artery aneurysm in Kawasaki disease; CRC cis rs4689592 0.513 rs3857177 chr4:7066332 G/A cg06697600 chr4:7070879 GRPEL1 -0.5 -7.36 -0.38 1.48e-12 Monocyte percentage of white cells; CRC cis rs7082209 1.000 rs61856381 chr10:44811172 T/C cg09554077 chr10:44749378 NA 0.43 5.62 0.3 4.04e-8 Resistance to Mycobacterium tuberculosis in HIV-positive individuals measured by a negative tuberculin skin test (continuous); CRC cis rs1707322 0.752 rs4660313 chr1:46110841 A/G cg06784218 chr1:46089804 CCDC17 -0.64 -11.93 -0.55 1.63e-27 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs5769765 0.671 rs138832 chr22:50178082 A/G cg22709217 chr22:50311962 ALG12;CRELD2 -0.74 -9.71 -0.47 8.87e-20 Schizophrenia; CRC cis rs7224685 0.501 rs11650023 chr17:4012850 C/T cg10724054 chr17:3904396 NA 0.47 7.54 0.38 4.63e-13 Type 2 diabetes; CRC cis rs12681287 0.517 rs7462883 chr8:87526790 G/A cg27223183 chr8:87520930 FAM82B -0.53 -7.22 -0.37 3.55e-12 Caudate activity during reward; CRC cis rs13096480 0.583 rs17598137 chr3:49891362 G/T cg09399047 chr3:49059671 NDUFAF3;DALRD3 0.39 5.65 0.3 3.39e-8 Intelligence (multi-trait analysis); CRC trans rs6600671 0.899 rs11249432 chr1:121283476 T/A cg09829573 chr1:144692074 NBPF9 -0.42 -6.27 -0.33 1.14e-9 Hip geometry; CRC cis rs57221529 0.766 rs12522140 chr5:587261 C/A cg09021430 chr5:549028 NA -0.72 -7.85 -0.4 5.75e-14 Lung disease severity in cystic fibrosis; CRC cis rs6951245 1.000 rs28528096 chr7:1070912 G/C cg21664854 chr7:1097933 C7orf50;GPR146 0.79 8.92 0.44 3.39e-17 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs7917772 0.503 rs7096072 chr10:104299976 C/T cg11453585 chr10:104263688 ACTR1A;SUFU 0.9 16.75 0.68 5.87e-46 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC cis rs6840360 0.573 rs2407171 chr4:152256782 A/G cg09659197 chr4:152720779 NA 0.31 5.98 0.31 5.94e-9 Intelligence (multi-trait analysis); CRC cis rs6701037 1.000 rs7512413 chr1:175124789 C/T cg00321850 chr1:175162397 KIAA0040 -0.36 -5.9 -0.31 8.95e-9 Alcohol dependence; CRC cis rs561341 1.000 rs8077092 chr17:30281992 T/C cg23018236 chr17:30244563 NA -0.57 -7.48 -0.38 6.67e-13 Hip circumference adjusted for BMI; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg22080282 chr18:72920932 ZADH2 0.46 6.66 0.34 1.16e-10 Response to antipsychotic treatment; CRC trans rs9291683 0.552 rs10939656 chr4:10014646 A/C cg26043149 chr18:55253948 FECH 0.54 8.53 0.43 5.34e-16 Bone mineral density; CRC trans rs2243480 1.000 rs316325 chr7:65609518 G/A cg10756647 chr7:56101905 PSPH 0.74 7.72 0.39 1.37e-13 Diabetic kidney disease; CRC cis rs10504229 0.689 rs17801390 chr8:58054768 T/C cg02290350 chr8:58132656 NA -0.61 -6.94 -0.36 2.1e-11 Developmental language disorder (linguistic errors); CRC cis rs6540556 0.954 rs10863786 chr1:209937764 A/G cg23920097 chr1:209922102 NA -0.51 -6.49 -0.34 3.23e-10 Red blood cell count; CRC cis rs589448 0.967 rs634512 chr12:69754012 C/T cg22834771 chr12:69754056 YEATS4 -0.56 -8.75 -0.43 1.16e-16 Cerebrospinal fluid biomarker levels; CRC cis rs2013441 0.965 rs9896221 chr17:20180337 G/A cg13482628 chr17:19912719 NA -0.4 -6.22 -0.32 1.53e-9 Obesity-related traits; CRC cis rs6088580 0.634 rs945673 chr20:32964265 C/A cg24642439 chr20:33292090 TP53INP2 -0.37 -6.25 -0.33 1.25e-9 Glomerular filtration rate (creatinine); CRC trans rs2797160 0.651 rs6939969 chr6:126034563 C/T cg05039488 chr6:79577232 IRAK1BP1 0.6 9.39 0.46 1.06e-18 Endometrial cancer; CRC cis rs11997175 0.646 rs4463379 chr8:33692719 G/A cg04338863 chr8:33670619 NA 0.42 6.72 0.35 8.03e-11 Body mass index; CRC cis rs7769051 0.614 rs6912936 chr6:133102664 A/G cg22852734 chr6:133119734 C6orf192 0.93 11.05 0.52 2.33e-24 Type 2 diabetes nephropathy; CRC trans rs4689592 0.503 rs10516184 chr4:7060959 C/T cg07817883 chr1:32538562 TMEM39B -0.63 -7.0 -0.36 1.45e-11 Monocyte percentage of white cells; CRC cis rs7843479 0.562 rs11774629 chr8:21859315 C/T cg17168535 chr8:21777572 XPO7 0.61 10.33 0.49 7.6e-22 Mean corpuscular volume; CRC cis rs6570726 0.791 rs6915094 chr6:145883540 C/G cg23711669 chr6:146136114 FBXO30 0.77 13.51 0.6 2.14e-33 Lobe attachment (rater-scored or self-reported); CRC cis rs7917772 0.582 rs10786689 chr10:104356359 T/C cg11453585 chr10:104263688 ACTR1A;SUFU 0.82 15.29 0.64 3.12e-40 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC cis rs11249608 0.548 rs34881171 chr5:178451932 C/T cg01312482 chr5:178451176 ZNF879 -0.37 -6.15 -0.32 2.27e-9 Pubertal anthropometrics; CRC cis rs11214589 0.747 rs7939992 chr11:113229665 T/C cg14159747 chr11:113255604 NA 0.46 8.5 0.42 6.84e-16 Neuroticism; CRC cis rs17065868 0.764 rs9533860 chr13:45033061 A/T cg10246903 chr13:45222710 NA 0.54 5.69 0.3 2.79e-8 Antineutrophil cytoplasmic antibody-associated vasculitis; CRC cis rs7731657 0.509 rs2250348 chr5:130243531 T/A cg08523029 chr5:130500466 HINT1 -0.47 -6.05 -0.32 3.95e-9 Fasting plasma glucose; CRC cis rs17532515 0.628 rs7693034 chr4:141478679 C/G cg09181644 chr4:141490428 UCP1 -0.32 -5.85 -0.31 1.19e-8 Select biomarker traits; CRC cis rs12926788 0.542 rs6497759 chr16:24801737 G/A cg02428538 chr16:24856791 SLC5A11 -0.56 -6.6 -0.34 1.67e-10 Ejection fraction in Tripanosoma cruzi seropositivity; CRC cis rs7615952 0.534 rs1503072 chr3:125754691 C/T cg15145296 chr3:125709740 NA -0.57 -6.5 -0.34 2.98e-10 Blood pressure (smoking interaction); CRC cis rs2019137 1.000 rs2019137 chr2:113973632 G/A cg19083407 chr2:113993142 PAX8;LOC440839;LOC654433 -0.47 -6.7 -0.35 9.26e-11 Lymphocyte counts; CRC trans rs877282 0.891 rs12767062 chr10:797961 C/T cg22713356 chr15:30763199 NA 1.34 16.78 0.68 4.27e-46 Uric acid levels; CRC cis rs11098499 0.532 rs4504231 chr4:120586891 G/A cg24375607 chr4:120327624 NA 0.52 8.12 0.41 9.4e-15 Corneal astigmatism; CRC cis rs881375 0.967 rs7034653 chr9:123687372 G/A cg00246817 chr9:123691163 NA -0.44 -5.74 -0.3 2.13e-8 Rheumatoid arthritis; CRC cis rs9818758 0.607 rs12715434 chr3:49295025 G/C cg00383909 chr3:49044727 WDR6 1.12 10.8 0.51 1.76e-23 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; CRC cis rs3087591 0.959 rs8076441 chr17:29405878 C/T cg24425628 chr17:29625626 OMG;NF1 -0.62 -10.27 -0.49 1.17e-21 Hip circumference; CRC cis rs3820068 0.580 rs7512308 chr1:16006604 C/A cg24675056 chr1:15929824 NA 0.51 6.79 0.35 5.1e-11 Systolic blood pressure; CRC cis rs7917772 0.582 rs10786685 chr10:104323103 C/T cg11453585 chr10:104263688 ACTR1A;SUFU 0.81 14.44 0.62 6.24e-37 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC cis rs8031584 0.706 rs2177670 chr15:31157751 G/T cg08109568 chr15:31115862 NA -0.68 -10.64 -0.51 6.3e-23 Huntington's disease progression; CRC cis rs11864453 0.647 rs8043606 chr16:72135319 T/C cg23815491 chr16:72088622 HP 0.49 7.51 0.38 5.77e-13 Fibrinogen levels; CRC cis rs3617 0.573 rs4687682 chr3:52916939 T/C cg07507251 chr3:52567010 NT5DC2 -0.41 -6.42 -0.33 4.78e-10 Red blood cell count;Autism spectrum disorder or schizophrenia; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg06852250 chr1:171750693 METTL13 0.4 6.04 0.32 4.12e-9 Intelligence (multi-trait analysis); CRC cis rs4665809 0.590 rs7586047 chr2:26447335 A/G cg08067268 chr2:26466485 HADHB;HADHA -0.65 -8.34 -0.42 2e-15 Gut microbiome composition (summer); CRC cis rs10504229 0.683 rs10504221 chr8:58140256 A/G cg02290350 chr8:58132656 NA -0.58 -8.16 -0.41 7.29e-15 Developmental language disorder (linguistic errors); CRC cis rs208520 0.874 rs208514 chr6:66945520 G/A cg07460842 chr6:66804631 NA -0.95 -12.36 -0.56 4.34e-29 Exhaled nitric oxide output; CRC cis rs875971 0.964 rs55748098 chr7:65763618 T/C cg18912574 chr7:65842487 NCRNA00174 -0.37 -6.39 -0.33 5.79e-10 Aortic root size; CRC cis rs6499255 1.000 rs11644838 chr16:69812705 G/C cg04110750 chr16:69646130 NFAT5 -0.52 -6.91 -0.36 2.54e-11 IgE levels; CRC cis rs7959663 1 rs7959663 chr12:109884367 G/C cg05360138 chr12:110035743 NA 0.5 6.18 0.32 1.93e-9 Bipolar disorder lithium response (categorical) or schizophrenia; CRC cis rs6500602 0.627 rs863501 chr16:4588394 G/C cg08645402 chr16:4508243 NA -0.58 -9.27 -0.46 2.47e-18 Schizophrenia; CRC cis rs7020830 0.898 rs308495 chr9:37277603 G/T cg14294708 chr9:37120828 ZCCHC7 1.03 19.74 0.74 8.95e-58 Schizophrenia; CRC cis rs832540 0.618 rs41106 chr5:56145057 G/T cg20203395 chr5:56204925 C5orf35 -0.46 -6.35 -0.33 7.36e-10 Coronary artery disease; CRC cis rs7493 0.950 rs6961624 chr7:95037661 T/C cg17330251 chr7:94953956 PON1 -0.56 -7.4 -0.38 1.17e-12 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs3772130 0.924 rs55643643 chr3:121440197 A/C cg20356878 chr3:121714668 ILDR1 0.51 7.8 0.4 8.06e-14 Cognitive performance; CRC trans rs7647973 0.626 rs11720705 chr3:49753788 A/G cg21665057 chr3:196295764 WDR53;FBXO45 -0.6 -6.85 -0.35 3.69e-11 Menarche (age at onset); CRC cis rs9322193 0.923 rs7753812 chr6:150011286 C/T cg05861140 chr6:150128134 PCMT1 -0.42 -6.87 -0.35 3.13e-11 Lung cancer; CRC cis rs6582630 0.519 rs10880629 chr12:38533611 T/G cg26384229 chr12:38710491 ALG10B 0.71 10.14 0.49 3.43e-21 Drug-induced liver injury (flucloxacillin); CRC cis rs4594175 0.926 rs11157803 chr14:51627700 C/T cg23942311 chr14:51606299 NA 0.65 10.87 0.51 1.03e-23 Cancer; CRC cis rs6502050 0.835 rs10163482 chr17:80110394 C/A cg25804541 chr17:80189381 SLC16A3 -0.31 -5.97 -0.31 6.08e-9 Life satisfaction; CRC cis rs1448094 0.512 rs4540904 chr12:86235472 A/G cg02569458 chr12:86230093 RASSF9 0.42 7.24 0.37 3.13e-12 Major depressive disorder; CRC cis rs7589728 1.000 rs6722069 chr2:88533151 C/T cg04511125 chr2:88470314 THNSL2 0.7 7.1 0.36 7.8e-12 Plasma clusterin levels; CRC cis rs9649213 0.593 rs13246843 chr7:98002661 G/T cg21770322 chr7:97807741 LMTK2 0.52 8.47 0.42 8.07e-16 Prostate cancer (SNP x SNP interaction); CRC cis rs6951245 0.554 rs35126802 chr7:1134842 C/T cg18402987 chr7:1209562 NA 0.51 6.18 0.32 1.86e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs6723226 0.882 rs13035097 chr2:32836362 A/G cg02381751 chr2:32503542 YIPF4 -0.5 -7.06 -0.36 9.63e-12 Intelligence (multi-trait analysis); CRC cis rs172166 0.561 rs149974 chr6:27985096 T/C cg25164649 chr6:28176230 NA 0.46 6.76 0.35 6.23e-11 Cardiac Troponin-T levels; CRC cis rs2303759 0.515 rs2334867 chr19:49788205 C/T cg22307029 chr19:49891270 CCDC155 -0.52 -6.84 -0.35 3.97e-11 Multiple sclerosis; CRC cis rs9916302 0.653 rs4239223 chr17:37717004 T/C cg07936489 chr17:37558343 FBXL20 -0.92 -12.03 -0.55 7.01e-28 Glomerular filtration rate (creatinine); CRC cis rs6951245 0.515 rs78461900 chr7:1007033 C/A cg07930192 chr7:1003750 NA 0.69 5.74 0.3 2.14e-8 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs7826238 0.623 rs2976893 chr8:8338219 G/T cg08975724 chr8:8085496 FLJ10661 -0.42 -6.37 -0.33 6.37e-10 Systolic blood pressure; CRC cis rs2050392 0.737 rs7898978 chr10:30699800 T/C cg18806716 chr10:30721971 MAP3K8 0.7 10.25 0.49 1.43e-21 Inflammatory bowel disease; CRC cis rs728616 0.867 rs57257258 chr10:81844020 T/C cg05935833 chr10:81318306 SFTPA2 -0.55 -6.55 -0.34 2.18e-10 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs9910055 0.529 rs408282 chr17:42182267 A/G cg09913183 chr17:42254507 C17orf65;ASB16 -0.5 -6.73 -0.35 7.62e-11 Total body bone mineral density; CRC cis rs875971 0.545 rs316305 chr7:65617971 G/A cg03233332 chr7:66118400 NA 0.44 6.2 0.32 1.65e-9 Aortic root size; CRC cis rs939658 0.683 rs8024572 chr15:79465600 A/G cg17916960 chr15:79447300 NA 0.45 7.05 0.36 1.04e-11 Refractive error; CRC cis rs2836950 0.501 rs2836980 chr21:40687618 G/T cg11890956 chr21:40555474 PSMG1 -0.61 -8.99 -0.44 1.95e-17 Menarche (age at onset); CRC cis rs370915 0.578 rs2375939 chr4:187783726 G/A cg12892747 chr4:187813459 NA -0.57 -8.28 -0.42 3.13e-15 Gout; CRC cis rs7937682 1.000 rs11608122 chr11:111535105 C/T cg09085632 chr11:111637200 PPP2R1B 1.02 18.97 0.72 1.01e-54 Primary sclerosing cholangitis; CRC cis rs6964587 0.869 rs10250641 chr7:91490746 C/T cg17063962 chr7:91808500 NA 0.72 12.22 0.56 1.46e-28 Breast cancer; CRC cis rs1448094 0.511 rs10863079 chr12:86152700 T/A cg18827107 chr12:86230957 RASSF9 0.39 5.98 0.31 5.76e-9 Major depressive disorder; CRC cis rs12762955 0.608 rs7922760 chr10:1156815 G/C cg18964960 chr10:1102726 WDR37 -0.43 -5.69 -0.3 2.76e-8 Response to angiotensin II receptor blocker therapy; CRC cis rs6714710 0.603 rs6746768 chr2:98466647 C/T cg26665480 chr2:98280029 ACTR1B 0.52 7.23 0.37 3.38e-12 Posterior cortical atrophy and Alzheimer's disease; CRC cis rs7809950 1.000 rs7809950 chr7:107237807 T/C cg23024343 chr7:107201750 COG5 0.64 9.28 0.46 2.3e-18 Coronary artery disease; CRC trans rs2303319 0.504 rs58622044 chr2:162596287 A/G cg24655899 chr17:79519568 C17orf70 -0.7 -5.98 -0.31 5.92e-9 Cognitive function; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg23475260 chr19:36505236 ALKBH6 0.42 6.75 0.35 6.52e-11 Liver disease severity in Alagille syndrome; CRC cis rs2836974 0.666 rs2836975 chr21:40663620 A/G cg17971929 chr21:40555470 PSMG1 -0.71 -11.09 -0.52 1.68e-24 Cognitive function; CRC cis rs12908161 0.920 rs12904605 chr15:85201419 T/C cg11189052 chr15:85197271 WDR73 0.63 9.08 0.45 9.97e-18 Schizophrenia; CRC cis rs950169 0.579 rs12913054 chr15:84664456 A/G cg03959625 chr15:84868606 LOC388152 0.4 5.61 0.3 4.29e-8 Schizophrenia; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg05358025 chr19:4868071 PLIN3 0.46 6.63 0.34 1.36e-10 Response to antipsychotic treatment; CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg25365794 chr17:8022404 ALOXE3 -0.5 -6.01 -0.31 4.84e-9 Diisocyanate-induced asthma; CRC cis rs1552244 0.554 rs3846169 chr3:9997054 A/G cg02579736 chr3:10068473 FANCD2;CIDECP -0.62 -8.88 -0.44 4.43e-17 Alzheimer's disease; CRC cis rs9393692 0.905 rs7450556 chr6:26299900 C/T cg00631329 chr6:26305371 NA -0.69 -13.26 -0.59 1.97e-32 Educational attainment; CRC cis rs11997175 0.574 rs7001404 chr8:33645219 G/A ch.8.33884649F chr8:33765107 NA 0.47 7.56 0.38 4.15e-13 Body mass index; CRC cis rs951366 0.589 rs823099 chr1:205669322 C/A cg07167872 chr1:205819463 PM20D1 0.78 11.3 0.53 3.04e-25 Menarche (age at onset); CRC cis rs9322193 0.736 rs10457851 chr6:150096352 T/A cg07701084 chr6:150067640 NUP43 0.47 6.61 0.34 1.51e-10 Lung cancer; CRC cis rs1740073 0.690 rs1740071 chr6:43944859 C/T cg14777908 chr6:43939685 NA -0.49 -8.2 -0.41 5.32e-15 Vascular endothelial growth factor levels; CRC trans rs2014572 0.967 rs11667407 chr19:57763122 C/T cg02674126 chr19:40336878 FBL 0.42 6.74 0.35 6.98e-11 Hyperactive-impulsive symptoms; CRC cis rs1448094 0.544 rs56330110 chr12:86166666 A/G cg25456477 chr12:86230367 RASSF9 0.36 6.11 0.32 2.82e-9 Major depressive disorder; CRC cis rs17666538 0.585 rs336444 chr8:633123 C/G cg07234876 chr8:600039 NA -0.71 -7.63 -0.39 2.55e-13 IgG glycosylation; CRC cis rs10197940 0.578 rs1061305 chr2:152346979 T/C cg06191203 chr2:152266755 RIF1 -0.46 -6.55 -0.34 2.22e-10 Lung cancer; CRC cis rs9549260 0.753 rs9549246 chr13:41220755 G/A cg21288729 chr13:41239152 FOXO1 0.48 6.04 0.32 4.12e-9 Red blood cell count; CRC trans rs2243480 0.901 rs2949697 chr7:65464236 A/G cg10756647 chr7:56101905 PSPH 0.73 7.98 0.4 2.44e-14 Diabetic kidney disease; CRC cis rs10751667 0.961 rs6597953 chr11:991099 G/A cg23136738 chr11:925521 AP2A2 -0.48 -7.63 -0.39 2.52e-13 Alzheimer's disease (late onset); CRC cis rs7772486 0.686 rs1011596 chr6:146076433 A/G cg23711669 chr6:146136114 FBXO30 0.66 10.98 0.52 4.01e-24 Lobe attachment (rater-scored or self-reported); CRC cis rs6496667 0.510 rs7495784 chr15:91068882 T/C cg04176472 chr15:90893244 GABARAPL3 -0.36 -5.65 -0.3 3.49e-8 Rheumatoid arthritis; CRC cis rs9308731 0.644 rs3789068 chr2:111909247 A/G cg18646521 chr2:111875858 NA 0.4 6.31 0.33 8.84e-10 Chronic lymphocytic leukemia; CRC cis rs7659604 1.000 rs6846232 chr4:122664805 A/G cg19748678 chr4:122722346 EXOSC9 0.54 8.6 0.43 3.36e-16 Type 2 diabetes; CRC cis rs60871478 0.588 rs73043546 chr7:857513 C/G cg13844804 chr7:814759 HEATR2 -0.64 -6.52 -0.34 2.63e-10 Cerebrospinal P-tau181p levels; CRC cis rs2280381 0.510 rs1474176 chr16:86008814 A/G cg04454285 chr16:86016317 NA 0.42 6.57 0.34 2.03e-10 Rheumatoid arthritis; CRC cis rs769267 0.931 rs2965193 chr19:19454828 G/A cg03709012 chr19:19516395 GATAD2A -0.67 -10.15 -0.49 3.03e-21 Tonsillectomy; CRC cis rs1401999 0.510 rs17817736 chr3:183720313 A/T cg01324343 chr3:183735012 ABCC5 -0.51 -8.07 -0.41 1.29e-14 Anterior chamber depth; CRC cis rs4716602 0.548 rs34245976 chr7:156160897 T/G cg16983916 chr7:156159713 NA -0.39 -6.79 -0.35 5.4e-11 Anti-saccade response; CRC cis rs477895 0.653 rs11601577 chr11:63928574 C/T cg19465662 chr11:63993652 NUDT22;TRPT1 0.72 9.05 0.45 1.31e-17 Mean platelet volume; CRC cis rs1129187 0.935 rs4987173 chr6:42931224 G/A cg21280719 chr6:42927975 GNMT -0.44 -9.74 -0.47 7.12e-20 Alzheimer's disease in APOE e4+ carriers; CRC cis rs1552244 1.000 rs34179822 chr3:10140017 A/G cg00166722 chr3:10149974 C3orf24 0.63 8.78 0.44 9.09e-17 Alzheimer's disease; CRC cis rs853679 0.517 rs1853097 chr6:28058635 A/G cg18032046 chr6:28092343 ZSCAN16 -0.5 -5.84 -0.31 1.26e-8 Depression; CRC cis rs6456156 1.000 rs6456156 chr6:167522300 T/C cg05540913 chr6:167530185 CCR6 0.33 5.75 0.3 2.09e-8 Primary biliary cholangitis; CRC cis rs6484504 0.600 rs1323738 chr11:31344898 T/C cg14844989 chr11:31128820 NA 0.35 6.24 0.33 1.37e-9 Red blood cell count; CRC cis rs6500602 0.674 rs8051695 chr16:4536621 T/C cg14951292 chr16:4525986 HMOX2;NMRAL1 0.65 9.44 0.46 6.85e-19 Schizophrenia; CRC trans rs561341 0.709 rs8068049 chr17:30183857 T/C cg20587970 chr11:113659929 NA 1.02 11.12 0.52 1.31e-24 Hip circumference adjusted for BMI; CRC cis rs7824557 0.583 rs2736292 chr8:11234500 A/T cg08071915 chr8:12219732 FAM66A -0.34 -6.29 -0.33 1.02e-9 Retinal vascular caliber; CRC cis rs2115630 0.645 rs6496284 chr15:85178270 A/G cg09876464 chr15:85330779 ZNF592 0.39 6.45 0.34 3.96e-10 P wave terminal force; CRC cis rs7772486 0.790 rs2254288 chr6:146204470 G/A cg23711669 chr6:146136114 FBXO30 0.65 11.23 0.53 5.24e-25 Lobe attachment (rater-scored or self-reported); CRC cis rs7119 0.717 rs12901338 chr15:77804900 T/A cg10437265 chr15:77819839 NA 0.67 11.9 0.55 2.1e-27 Type 2 diabetes; CRC cis rs12476592 0.602 rs10469945 chr2:63816776 T/C cg10828910 chr2:63850056 LOC388955 0.49 6.06 0.32 3.75e-9 Childhood ear infection; CRC cis rs1448094 0.836 rs7313442 chr12:86405642 C/T cg18827107 chr12:86230957 RASSF9 -0.37 -5.86 -0.31 1.12e-8 Major depressive disorder; CRC cis rs939584 1.000 rs7570198 chr2:648198 C/T cg03610516 chr2:642275 NA 0.41 5.9 0.31 8.8e-9 Body mass index; CRC cis rs5753618 0.583 rs8141150 chr22:31800336 C/T cg07713946 chr22:31675144 LIMK2 0.4 5.95 0.31 6.81e-9 Colorectal cancer; CRC cis rs7605827 0.930 rs2049718 chr2:15518589 A/G cg19274914 chr2:15703543 NA -0.37 -5.66 -0.3 3.34e-8 Educational attainment (years of education); CRC cis rs1395 0.778 rs72810794 chr2:27401260 C/T cg14242246 chr2:27434262 C2orf28;SLC5A6 0.41 7.58 0.39 3.54e-13 Blood metabolite levels; CRC cis rs4862750 0.872 rs6825289 chr4:187879109 T/G cg03452623 chr4:187889614 NA -0.9 -21.04 -0.76 7.13e-63 Lobe attachment (rater-scored or self-reported); CRC cis rs6952808 1.000 rs10260585 chr7:1889521 G/A cg00106254 chr7:1943704 MAD1L1 -0.46 -6.5 -0.34 2.94e-10 Bipolar disorder and schizophrenia; CRC cis rs116095464 0.510 rs60844864 chr5:267000 A/G cg22857025 chr5:266934 NA -1.26 -16.72 -0.68 7.53e-46 Breast cancer; CRC cis rs801193 0.967 rs2707849 chr7:66152712 T/C cg11764359 chr7:65958608 NA 0.55 8.45 0.42 9.38e-16 Aortic root size; CRC cis rs9311474 0.659 rs1133415 chr3:52575831 G/A cg05573699 chr3:52720067 GNL3;PBRM1 -0.38 -5.61 -0.3 4.25e-8 Electroencephalogram traits; CRC cis rs763014 0.932 rs2384972 chr16:674424 G/A cg00908189 chr16:619842 PIGQ 0.68 11.24 0.53 5.19e-25 Height; CRC cis rs12200560 0.505 rs4839849 chr6:97076673 T/C cg06623918 chr6:96969491 KIAA0776 0.52 7.77 0.39 1.02e-13 Coronary heart disease; CRC cis rs9462846 1.000 rs2395941 chr6:42867821 G/A cg10862848 chr6:42927986 GNMT -0.3 -5.68 -0.3 3.04e-8 Blood protein levels; CRC cis rs16867321 1.000 rs16867330 chr2:181446202 T/G cg23363182 chr2:181467187 NA -0.55 -7.01 -0.36 1.35e-11 Obesity; CRC cis rs3785574 0.962 rs16947051 chr17:61790917 G/C cg22520471 chr17:61851767 DDX42;CCDC47 0.44 6.11 0.32 2.82e-9 Height; CRC cis rs1008375 0.932 rs9291660 chr4:17663414 A/G cg16339924 chr4:17578868 LAP3 0.47 5.96 0.31 6.61e-9 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs13108904 0.935 rs6853002 chr4:1295991 C/T cg20887711 chr4:1340912 KIAA1530 0.45 6.5 0.34 2.93e-10 Obesity-related traits; CRC cis rs2073300 0.609 rs2295238 chr20:23387946 C/G cg12062639 chr20:23401060 NAPB 0.64 6.19 0.32 1.81e-9 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs10883723 0.810 rs7090276 chr10:104281239 G/T cg11453585 chr10:104263688 ACTR1A;SUFU 0.91 17.47 0.69 8.43e-49 Allergic disease (asthma, hay fever or eczema); CRC trans rs9291683 0.935 rs1860911 chr4:10275057 C/T cg26043149 chr18:55253948 FECH 0.47 7.45 0.38 8.18e-13 Bone mineral density; CRC cis rs3026101 0.671 rs1989946 chr17:5313152 T/A cg25236894 chr17:5323110 RPAIN;NUP88 0.44 7.26 0.37 2.82e-12 Body mass index; CRC cis rs7666738 0.753 rs2903143 chr4:99040480 C/T cg05340658 chr4:99064831 C4orf37 0.58 9.01 0.44 1.7e-17 Colonoscopy-negative controls vs population controls; CRC cis rs1143633 0.615 rs4364030 chr2:113664409 C/G cg06771106 chr2:113671356 IL1F7 0.41 5.97 0.31 6.27e-9 Allergic disease (asthma, hay fever or eczema); CRC cis rs7666738 0.830 rs34313689 chr4:99013689 T/C cg05340658 chr4:99064831 C4orf37 0.63 9.79 0.47 5.01e-20 Colonoscopy-negative controls vs population controls; CRC cis rs9549328 0.800 rs9549617 chr13:113628070 C/A cg16822035 chr13:113633379 MCF2L -0.29 -6.01 -0.31 4.96e-9 Systolic blood pressure; CRC cis rs10504229 0.683 rs34859456 chr8:58117722 A/C cg04204079 chr8:58130323 NA -0.45 -5.78 -0.3 1.71e-8 Developmental language disorder (linguistic errors); CRC cis rs8077889 1.000 rs2342310 chr17:41866199 T/C cg26893861 chr17:41843967 DUSP3 0.99 12.71 0.57 2.26e-30 Triglycerides; CRC cis rs2243480 1.000 rs1723270 chr7:65469830 T/G cg18252515 chr7:66147081 NA -1.07 -12.3 -0.56 7.44e-29 Diabetic kidney disease; CRC cis rs1178968 1.000 rs1178969 chr7:72759114 A/G cg25889504 chr7:72793014 NA 0.54 6.08 0.32 3.4e-9 Triglyceride levels; CRC cis rs523516 0.645 rs16527 chr17:37322080 T/C cg20555674 chr17:37321631 ARL5C 0.39 8.03 0.41 1.69e-14 IgG glycosylation; CRC cis rs2153535 0.580 rs6597326 chr6:8482019 A/C cg07606381 chr6:8435919 SLC35B3 0.67 10.78 0.51 2.07e-23 Motion sickness; CRC cis rs11212617 0.967 rs183460 chr11:108090710 A/C cg14761454 chr11:108092087 ATM;NPAT 0.43 6.25 0.33 1.28e-9 Response to metformin in type 2 diabetes (glycemic); CRC cis rs12541635 0.966 rs6469031 chr8:107048095 T/C cg10147462 chr8:107024639 NA 0.45 7.56 0.38 3.98e-13 Age of smoking initiation; CRC cis rs6500602 0.561 rs62039231 chr16:4519548 A/G cg14951292 chr16:4525986 HMOX2;NMRAL1 0.53 7.75 0.39 1.19e-13 Schizophrenia; CRC cis rs13108904 0.870 rs13132584 chr4:1251504 G/T cg00684032 chr4:1343700 KIAA1530 0.46 6.88 0.35 3.02e-11 Obesity-related traits; CRC cis rs28386778 0.863 rs2251164 chr17:61884120 G/A cg06601766 chr17:61851465 DDX42;CCDC47 0.44 5.96 0.31 6.5e-9 Prudent dietary pattern; CRC cis rs3806843 0.547 rs246010 chr5:140336635 A/T cg19875535 chr5:140030758 IK 0.4 6.12 0.32 2.64e-9 Depressive symptoms (multi-trait analysis); CRC trans rs11148252 0.774 rs9536066 chr13:52983981 A/G cg18335740 chr13:41363409 SLC25A15 0.55 8.72 0.43 1.42e-16 Lewy body disease; CRC cis rs798554 1.000 rs798540 chr7:2764130 G/A cg19346786 chr7:2764209 NA -0.42 -7.37 -0.38 1.42e-12 Height; CRC cis rs713587 0.967 rs10182181 chr2:25150296 C/T cg04586622 chr2:25135609 ADCY3 0.47 8.41 0.42 1.23e-15 Body mass index in non-asthmatics; CRC cis rs763121 0.853 rs5757203 chr22:39044152 G/C cg06022373 chr22:39101656 GTPBP1 0.78 12.39 0.56 3.54e-29 Menopause (age at onset); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg05606039 chr17:73511506 TSEN54;CASKIN2 0.41 6.46 0.34 3.83e-10 Liver disease severity in Alagille syndrome; CRC cis rs9400239 0.622 rs1268166 chr6:109008232 T/C cg11073813 chr6:109029018 NA -0.41 -6.45 -0.34 3.94e-10 Waist circumference;Body mass index;BMI (adjusted for smoking behaviour); CRC trans rs4650994 0.525 rs2811295 chr1:178551267 C/T cg05059571 chr16:84539110 KIAA1609 0.57 7.85 0.4 6.02e-14 HDL cholesterol levels;HDL cholesterol; CRC cis rs1691799 0.899 rs1168294 chr12:66733988 T/C cg16791601 chr12:66731901 HELB -0.66 -10.92 -0.52 6.61e-24 White blood cell count (basophil); CRC cis rs3806843 1.000 rs3806845 chr5:140180737 C/T cg16607685 chr5:140181889 PCDHA2;PCDHA1;PCDHA3 -0.27 -6.23 -0.32 1.4e-9 Depressive symptoms (multi-trait analysis); CRC trans rs11031096 0.738 rs11031070 chr11:4154307 T/C cg22978087 chr8:24814126 NEFL 0.33 6.08 0.32 3.37e-9 Mean corpuscular volume;Mean corpuscular hemoglobin; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg07843956 chr16:692375 FAM195A 0.5 6.74 0.35 7.23e-11 Anxiety disorder; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg09252528 chr19:42901252 NA 0.47 6.55 0.34 2.19e-10 Response to antipsychotic treatment; CRC cis rs10791323 0.569 rs10750553 chr11:133740251 T/C cg06766960 chr11:133703094 NA -0.35 -6.44 -0.33 4.29e-10 Childhood ear infection; CRC cis rs7172809 0.607 rs78928643 chr15:77842297 A/G cg10437265 chr15:77819839 NA -0.36 -5.99 -0.31 5.65e-9 Glucose homeostasis traits; CRC cis rs116095464 0.510 rs7714944 chr5:231765 C/T cg22857025 chr5:266934 NA -1.19 -15.96 -0.66 6.93e-43 Breast cancer; CRC cis rs2832191 1.000 rs2832184 chr21:30483265 C/T cg08807101 chr21:30365312 RNF160 -0.61 -9.95 -0.48 1.47e-20 Dental caries; CRC cis rs72945132 0.660 rs67433166 chr11:70121604 T/A cg14191688 chr11:70257035 CTTN 0.42 5.85 0.31 1.18e-8 Coronary artery disease; CRC cis rs9914988 1.000 rs9916866 chr17:27183155 C/G cg16670446 chr17:27188758 MIR451;MIR144 -0.61 -10.36 -0.5 5.96e-22 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs9911578 0.967 rs2567892 chr17:56668929 T/C cg12560992 chr17:57184187 TRIM37 0.91 16.88 0.68 1.72e-46 Intelligence (multi-trait analysis); CRC cis rs863345 0.604 rs12063320 chr1:158499423 A/T cg12129480 chr1:158549410 OR10X1 -0.3 -6.27 -0.33 1.12e-9 Pneumococcal bacteremia; CRC cis rs10971721 0.822 rs72725381 chr9:33851165 A/T cg13495928 chr9:33750294 PRSS3 0.55 5.9 0.31 9.17e-9 Body mass index; CRC cis rs6901250 0.851 rs7760125 chr6:117123391 A/C cg12892004 chr6:117198278 RFX6 0.45 7.02 0.36 1.27e-11 C-reactive protein levels; CRC cis rs593982 0.920 rs10896044 chr11:65554680 C/G cg08755490 chr11:65554678 OVOL1 1.22 16.44 0.67 9.33e-45 Atopic dermatitis; CRC cis rs881375 0.678 rs7037195 chr9:123684000 T/C cg09419670 chr9:123605666 PSMD5;LOC253039 0.46 7.08 0.36 8.79e-12 Rheumatoid arthritis; CRC cis rs7618915 0.547 rs2268027 chr3:52766606 G/A cg15147215 chr3:52552868 STAB1 -0.61 -10.04 -0.48 7.46e-21 Bipolar disorder; CRC cis rs870825 0.929 rs72689263 chr4:185590961 C/T cg04058563 chr4:185651563 MLF1IP 0.56 5.89 0.31 9.54e-9 Blood protein levels; CRC trans rs3942852 0.606 rs10734561 chr11:48097480 C/T cg15704280 chr7:45808275 SEPT13 -0.65 -8.34 -0.42 2e-15 Acute lymphoblastic leukemia (childhood); CRC cis rs9814567 1.000 rs4498009 chr3:134198008 C/G cg06541857 chr3:134203789 ANAPC13;CEP63 -0.39 -5.77 -0.3 1.79e-8 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs7020830 0.867 rs563132 chr9:37245476 A/T cg14294708 chr9:37120828 ZCCHC7 1.06 20.83 0.75 4.84e-62 Schizophrenia; CRC trans rs7613875 0.578 rs4688753 chr3:50074773 A/G cg21665057 chr3:196295764 WDR53;FBXO45 -0.47 -7.08 -0.36 8.67e-12 Body mass index; CRC cis rs734999 0.588 rs10910098 chr1:2533250 C/A cg18854424 chr1:2615690 NA 0.42 8.06 0.41 1.41e-14 Ulcerative colitis; CRC cis rs2243480 1.000 rs35046236 chr7:65408613 T/C cg18252515 chr7:66147081 NA -1.06 -12.44 -0.57 2.13e-29 Diabetic kidney disease; CRC cis rs853679 0.517 rs9468297 chr6:28118874 G/T cg02683197 chr6:28174875 NA 0.87 10.73 0.51 3.25e-23 Depression; CRC cis rs6502050 0.634 rs11077973 chr17:80095191 C/T cg02741985 chr17:80059408 CCDC57 0.43 7.15 0.37 5.66e-12 Life satisfaction; CRC cis rs6834538 1.000 rs2351761 chr4:113447911 A/G cg10021238 chr4:113569128 MIR367;LARP7 -0.44 -6.33 -0.33 8e-10 Free thyroxine concentration; CRC cis rs4664293 0.647 rs6734085 chr2:160452222 C/T cg08347373 chr2:160653686 CD302 -0.39 -6.49 -0.34 3.11e-10 Monocyte percentage of white cells; CRC cis rs1568889 1.000 rs1464897 chr11:28034844 C/G cg06544937 chr11:28130018 METT5D1;KIF18A 0.79 11.19 0.53 7.53e-25 Bipolar disorder; CRC cis rs10504229 0.654 rs903705 chr8:58128185 T/A cg02725872 chr8:58115012 NA -0.64 -11.55 -0.54 3.85e-26 Developmental language disorder (linguistic errors); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg04509940 chr21:45079326 HSF2BP;RRP1B 0.37 6.02 0.31 4.72e-9 Liver disease severity in Alagille syndrome; CRC cis rs780096 0.587 rs4665969 chr2:27574953 C/T cg27432699 chr2:27873401 GPN1 0.5 7.4 0.38 1.16e-12 Total body bone mineral density; CRC cis rs703842 0.616 rs870392 chr12:58219173 C/A cg00677455 chr12:58241039 CTDSP2 0.82 11.86 0.55 2.98e-27 Multiple sclerosis; CRC cis rs6951245 0.872 rs112309216 chr7:1100296 A/T cg21664854 chr7:1097933 C7orf50;GPR146 0.77 8.8 0.44 7.85e-17 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs6570726 0.935 rs398060 chr6:145841515 C/T cg23711669 chr6:146136114 FBXO30 -0.63 -10.37 -0.5 5.4e-22 Lobe attachment (rater-scored or self-reported); CRC cis rs6688613 0.694 rs3820387 chr1:166820284 A/T cg07049167 chr1:166818506 POGK 0.47 5.7 0.3 2.64e-8 Refractive astigmatism; CRC cis rs1153858 1.000 rs4775907 chr15:45638647 G/A cg21132104 chr15:45694354 SPATA5L1 0.58 8.6 0.43 3.24e-16 Homoarginine levels; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg18724257 chr3:53164314 RFT1 0.49 7.04 0.36 1.13e-11 Response to antipsychotic treatment; CRC cis rs17767392 0.813 rs12880291 chr14:71884567 G/T cg13720639 chr14:72061746 SIPA1L1 -0.5 -6.37 -0.33 6.4e-10 Mitral valve prolapse; CRC cis rs12086130 0.892 rs72904801 chr1:51442137 A/G cg07174182 chr1:51127561 FAF1 -0.73 -5.65 -0.3 3.49e-8 Hip circumference adjusted for BMI;Hip circumference; CRC cis rs7772486 0.754 rs702319 chr6:146006117 T/C cg23711669 chr6:146136114 FBXO30 -0.73 -11.88 -0.55 2.48e-27 Lobe attachment (rater-scored or self-reported); CRC trans rs7142881 0.508 rs4981109 chr14:32118067 C/T cg10453823 chr2:190539512 ANKAR 0.41 6.12 0.32 2.74e-9 Response to iloperidone treatment (QT prolongation); CRC cis rs9467711 0.606 rs13212985 chr6:26609989 G/C cg16898833 chr6:26189333 HIST1H4D 1.14 8.46 0.42 8.89e-16 Autism spectrum disorder or schizophrenia; CRC cis rs1448094 0.511 rs7959372 chr12:86160680 T/C cg25456477 chr12:86230367 RASSF9 0.39 6.56 0.34 2.04e-10 Major depressive disorder; CRC cis rs4692589 0.840 rs2727525 chr4:170960062 G/T cg19918862 chr4:170955249 NA 0.37 6.05 0.32 3.87e-9 Anxiety disorder; CRC cis rs7945705 0.837 rs10769981 chr11:9024460 T/C cg00186954 chr11:8933980 ST5;C11orf17 0.41 6.24 0.33 1.38e-9 Hemoglobin concentration; CRC cis rs7647973 0.710 rs34890793 chr3:49619493 C/T cg13072238 chr3:49761600 GMPPB -0.51 -5.78 -0.3 1.74e-8 Menarche (age at onset); CRC cis rs25645 0.502 rs7207600 chr17:38091660 G/A cg24910161 chr17:38119198 GSDMA -0.38 -6.26 -0.33 1.19e-9 Myeloid white cell count; CRC cis rs17092148 0.945 rs6060034 chr20:33351864 T/C cg08999081 chr20:33150536 PIGU 0.46 5.68 0.3 3.01e-8 Neuroticism; CRC cis rs909674 0.818 rs5750833 chr22:39843091 C/A cg11247378 chr22:39784982 NA -0.44 -8.67 -0.43 2e-16 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; CRC cis rs7586879 0.616 rs6545809 chr2:25126715 C/T cg04586622 chr2:25135609 ADCY3 -0.54 -10.01 -0.48 9.31e-21 Body mass index; CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg15933130 chr5:137089362 HNRNPA0 0.4 6.49 0.34 3.23e-10 Obesity-related traits; CRC cis rs1005277 0.579 rs932538 chr10:38381314 T/C cg25517755 chr10:38738941 LOC399744 -0.41 -6.1 -0.32 3.03e-9 Extrinsic epigenetic age acceleration; CRC cis rs7580658 0.864 rs4150454 chr2:128038544 T/C cg09760422 chr2:128146352 NA -0.29 -5.71 -0.3 2.54e-8 Protein C levels; CRC cis rs909341 0.710 rs3848669 chr20:62300811 G/T cg16989086 chr20:62203971 PRIC285 -0.48 -6.07 -0.32 3.62e-9 Atopic dermatitis; CRC cis rs3741404 0.620 rs12787945 chr11:63977546 G/A cg06243084 chr11:63990629 FERMT3 -0.4 -6.17 -0.32 2.04e-9 Platelet count; CRC cis rs9398803 0.865 rs9388496 chr6:126785062 A/G cg19875578 chr6:126661172 C6orf173 0.44 6.2 0.32 1.69e-9 Male-pattern baldness; CRC cis rs597539 0.652 rs602364 chr11:68662167 C/T cg06028808 chr11:68637592 NA 0.42 6.66 0.34 1.12e-10 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs35110281 0.633 rs4819289 chr21:45120237 A/G cg21573476 chr21:45109991 RRP1B -0.4 -6.04 -0.32 4.28e-9 Mean corpuscular volume; CRC cis rs7615952 0.599 rs66532274 chr3:125731845 G/A cg18479299 chr3:125709523 NA -0.49 -6.46 -0.34 3.8e-10 Blood pressure (smoking interaction); CRC cis rs1475911 0.708 rs11701371 chr21:43523972 C/G cg19766460 chr21:43528205 UMODL1;C21orf128 0.98 14.43 0.62 6.41e-37 IgG glycosylation; CRC cis rs12681287 0.640 rs72606633 chr8:87476236 T/C cg27223183 chr8:87520930 FAM82B -0.53 -7.52 -0.38 5.31e-13 Caudate activity during reward; CRC cis rs2456568 0.802 rs10765639 chr11:93636194 G/A cg26875233 chr11:93583750 C11orf90 -0.32 -6.27 -0.33 1.11e-9 Response to serotonin reuptake inhibitors in major depressive disorder; CRC cis rs28386778 0.897 rs2665844 chr17:61874455 A/G cg11494091 chr17:61959527 GH2 0.62 10.57 0.5 1.13e-22 Prudent dietary pattern; CRC cis rs2404602 0.716 rs12594577 chr15:76828793 A/C cg23625390 chr15:77176239 SCAPER 0.5 7.29 0.37 2.4e-12 Blood metabolite levels; CRC cis rs9837602 1.000 rs1688772 chr3:99503366 A/G cg07805332 chr3:99536008 MIR548G;C3orf26 0.45 5.92 0.31 8.25e-9 Breast cancer; CRC cis rs1401999 1.000 rs9858774 chr3:183652736 G/A cg01324343 chr3:183735012 ABCC5 0.82 14.87 0.63 1.31e-38 Anterior chamber depth; CRC cis rs909002 0.800 rs6703093 chr1:32093561 C/T cg13919466 chr1:32135498 COL16A1 -0.31 -5.8 -0.3 1.58e-8 Intelligence (multi-trait analysis); CRC cis rs2204008 0.744 rs1115514 chr12:38280140 C/T cg26384229 chr12:38710491 ALG10B 0.67 9.39 0.46 1.01e-18 Bladder cancer; CRC cis rs2204008 0.539 rs1283295 chr12:38146014 A/C cg13010199 chr12:38710504 ALG10B -0.43 -6.2 -0.32 1.69e-9 Bladder cancer; CRC cis rs929354 0.772 rs6969244 chr7:157004012 A/G cg17757837 chr7:157058334 UBE3C 0.75 12.69 0.57 2.65e-30 Body mass index; CRC cis rs826838 0.967 rs2892410 chr12:38990282 A/G cg13010199 chr12:38710504 ALG10B -0.45 -5.96 -0.31 6.57e-9 Heart rate; CRC cis rs10992471 0.603 rs7872610 chr9:95299137 G/C cg14631576 chr9:95140430 CENPP -0.4 -6.87 -0.35 3.13e-11 Visceral adipose tissue/subcutaneous adipose tissue ratio; CRC cis rs57994353 0.865 rs35857370 chr9:139354097 G/A cg13856295 chr9:139396418 NOTCH1 -0.42 -5.64 -0.3 3.61e-8 Eosinophil counts;Cutaneous squamous cell carcinoma; CRC trans rs1814175 0.803 rs11040451 chr11:49650639 C/T cg11707556 chr5:10655725 ANKRD33B -0.42 -7.73 -0.39 1.35e-13 Height; CRC cis rs7259376 0.775 rs2360621 chr19:22548669 C/T cg02657401 chr19:22469223 NA -0.31 -6.5 -0.34 2.98e-10 Menopause (age at onset); CRC cis rs6502050 0.835 rs28481866 chr17:80105160 G/A cg22110888 chr17:80059540 CCDC57 0.4 6.44 0.33 4.17e-10 Life satisfaction; CRC cis rs9894429 0.646 rs12603868 chr17:79618834 G/C cg18240062 chr17:79603768 NPLOC4 0.48 7.36 0.38 1.45e-12 Eye color traits; CRC cis rs6502050 0.637 rs74765203 chr17:80118223 A/G cg13198984 chr17:80129470 CCDC57 0.47 8.25 0.41 3.83e-15 Life satisfaction; CRC cis rs28386778 0.897 rs3744293 chr17:61841788 T/A cg25654072 chr17:61904446 PSMC5;FTSJ3 0.73 11.3 0.53 2.96e-25 Prudent dietary pattern; CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg03258011 chr17:54857409 NA -0.52 -6.45 -0.34 3.91e-10 Diisocyanate-induced asthma; CRC cis rs889398 0.771 rs4985448 chr16:69899395 A/G cg00738113 chr16:70207722 CLEC18C -0.37 -6.3 -0.33 9.79e-10 Body mass index; CRC cis rs3903072 0.528 rs7928652 chr11:65580228 A/C cg26695010 chr11:65641043 EFEMP2 -0.43 -5.96 -0.31 6.66e-9 Breast cancer; CRC cis rs8180040 0.903 rs7636423 chr3:47309134 C/G cg02527881 chr3:46936655 PTH1R -0.38 -7.05 -0.36 1.04e-11 Colorectal cancer; CRC trans rs61931739 0.500 rs10844863 chr12:34532284 C/T cg13010199 chr12:38710504 ALG10B 0.45 6.52 0.34 2.65e-10 Morning vs. evening chronotype; CRC cis rs3806843 0.576 rs246034 chr5:140332064 A/C cg19875535 chr5:140030758 IK 0.4 6.12 0.32 2.64e-9 Depressive symptoms (multi-trait analysis); CRC cis rs9787249 0.957 rs3738673 chr1:40204823 C/T cg19912559 chr1:40204330 PPIE 0.51 7.43 0.38 9.67e-13 Blood protein levels; CRC cis rs2415984 0.579 rs61993339 chr14:46969266 G/A cg14871534 chr14:47121158 RPL10L -0.43 -6.25 -0.33 1.24e-9 Number of children ever born; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg19091447 chr20:37555378 FAM83D 0.4 6.16 0.32 2.17e-9 Liver disease severity in Alagille syndrome; CRC cis rs1862618 0.802 rs42769 chr5:56144152 G/A cg24531977 chr5:56204891 C5orf35 -0.8 -10.85 -0.51 1.17e-23 Initial pursuit acceleration; CRC cis rs11112613 0.762 rs73184078 chr12:105950017 A/G cg03607813 chr12:105948248 NA 0.82 10.85 0.51 1.21e-23 Corrected insulin response;Corrected insulin response adjusted for insulin sensitivity index; CRC trans rs208520 1.000 rs208520 chr6:66952828 G/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.88 -10.95 -0.52 5.22e-24 Exhaled nitric oxide output; CRC cis rs13217239 0.646 rs10456351 chr6:26986792 C/T cg05192639 chr6:26864778 GUSBL1 0.31 6.01 0.31 5.05e-9 Schizophrenia; CRC cis rs9814567 0.964 rs9820425 chr3:134223018 G/C cg06109529 chr3:134205091 CEP63;ANAPC13 -0.81 -12.08 -0.55 4.67e-28 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs853679 0.517 rs4711165 chr6:28115184 T/G cg18032046 chr6:28092343 ZSCAN16 -0.51 -5.93 -0.31 7.47e-9 Depression; CRC cis rs1008375 1.000 rs2872958 chr4:17665032 A/G cg16339924 chr4:17578868 LAP3 0.53 6.88 0.35 3.1e-11 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs7945705 0.967 rs2568090 chr11:8849495 T/C cg00186954 chr11:8933980 ST5;C11orf17 0.38 5.77 0.3 1.86e-8 Hemoglobin concentration; CRC cis rs8072100 1.000 rs4794048 chr17:45763073 A/C cg08085267 chr17:45401833 C17orf57 -0.69 -11.42 -0.53 1.18e-25 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs7511006 1.000 rs17836662 chr22:50672154 A/G cg16473166 chr22:50639996 SELO -0.53 -7.95 -0.4 3.1e-14 Obesity-related traits; CRC cis rs6938 0.596 rs11072511 chr15:75159433 A/G cg18612461 chr15:75251733 NA 0.38 5.93 0.31 7.78e-9 Breast cancer; CRC cis rs28386778 0.897 rs2665796 chr17:61923716 G/C cg22520471 chr17:61851767 DDX42;CCDC47 0.74 11.65 0.54 1.76e-26 Prudent dietary pattern; CRC cis rs274567 0.501 rs274571 chr5:131712125 A/G cg22638593 chr5:131593259 PDLIM4 -0.39 -6.45 -0.34 3.98e-10 Blood metabolite levels; CRC cis rs7809950 0.953 rs28687365 chr7:107106712 A/C cg23024343 chr7:107201750 COG5 -0.61 -8.68 -0.43 1.91e-16 Coronary artery disease; CRC cis rs1348850 0.914 rs3902850 chr2:178315899 G/A cg22681709 chr2:178499509 PDE11A -0.4 -7.3 -0.37 2.19e-12 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC trans rs7618501 1.000 rs11130221 chr3:49819102 C/G cg21582582 chr3:182698605 DCUN1D1 0.56 8.34 0.42 2.09e-15 Intelligence (multi-trait analysis); CRC trans rs8035957 1.000 rs4924273 chr15:38846738 C/G cg11239145 chr4:26320844 RBPJ -0.53 -6.43 -0.33 4.39e-10 Type 1 diabetes; CRC cis rs6024905 1.000 rs6024905 chr20:36957837 C/T cg07053727 chr20:36965646 BPI 0.45 7.76 0.39 1.06e-13 Bipolar disorder and schizophrenia; CRC cis rs7523050 0.643 rs12736534 chr1:109399934 T/C cg08274380 chr1:109419600 GPSM2 0.84 6.6 0.34 1.69e-10 Fat distribution (HIV); CRC cis rs10504229 0.728 rs17804720 chr8:58154565 T/C cg24829409 chr8:58192753 C8orf71 -0.58 -7.96 -0.4 2.86e-14 Developmental language disorder (linguistic errors); CRC cis rs6502050 0.799 rs4482345 chr17:80152919 G/A cg22110888 chr17:80059540 CCDC57 0.39 6.25 0.33 1.27e-9 Life satisfaction; CRC cis rs4713118 0.527 rs36042294 chr6:27720712 C/G cg20933634 chr6:27740509 NA 0.45 6.56 0.34 2.05e-10 Parkinson's disease; CRC cis rs9302690 0.557 rs223875 chr16:57506915 C/T cg27017172 chr16:57497170 POLR2C 0.67 6.01 0.31 4.84e-9 Blood protein levels; CRC cis rs6502050 0.736 rs12150322 chr17:80061582 T/G cg19223190 chr17:80058835 NA -0.45 -7.18 -0.37 4.78e-12 Life satisfaction; CRC cis rs10493773 0.577 rs17398175 chr1:86074710 A/G cg17807903 chr1:86174739 ZNHIT6 -0.45 -8.23 -0.41 4.56e-15 Urate levels in overweight individuals; CRC cis rs1448094 0.511 rs4559760 chr12:86149414 G/A cg18827107 chr12:86230957 RASSF9 0.39 5.96 0.31 6.52e-9 Major depressive disorder; CRC cis rs68170813 0.559 rs61406169 chr7:106903421 A/T cg02696742 chr7:106810147 HBP1 -0.63 -7.01 -0.36 1.32e-11 Coronary artery disease; CRC cis rs1048238 0.506 rs12039892 chr1:16167974 A/G cg21385522 chr1:16154831 NA 0.63 9.08 0.45 1.03e-17 Systolic blood pressure; CRC cis rs6952808 0.895 rs4513875 chr7:1928159 C/T cg00106254 chr7:1943704 MAD1L1 -0.52 -7.78 -0.39 9.43e-14 Bipolar disorder and schizophrenia; CRC cis rs8044995 0.563 rs73613962 chr16:68361974 T/G cg05110241 chr16:68378359 PRMT7 -0.72 -7.03 -0.36 1.2e-11 Schizophrenia; CRC trans rs7615952 0.512 rs11921452 chr3:125359750 A/G cg03844506 chr4:4109441 NA -0.51 -7.57 -0.39 3.88e-13 Blood pressure (smoking interaction); CRC cis rs2739330 0.587 rs4820571 chr22:24242973 A/G cg23131131 chr22:24373011 LOC391322 -0.53 -7.7 -0.39 1.61e-13 Liver enzyme levels (gamma-glutamyl transferase); CRC trans rs5756813 0.727 rs4820303 chr22:38134166 G/A cg19894588 chr14:64061835 NA -0.61 -8.17 -0.41 6.48e-15 Optic cup area;Vertical cup-disc ratio; CRC cis rs9372498 0.536 rs17080302 chr6:118854037 A/G cg24463073 chr6:118973353 C6orf204 0.52 6.97 0.36 1.69e-11 Diastolic blood pressure; CRC cis rs7677751 0.806 rs6850748 chr4:55099164 T/G cg13615338 chr4:55094005 PDGFRA 0.4 5.62 0.3 3.97e-8 Corneal astigmatism; CRC cis rs9322193 0.923 rs3798761 chr6:150004779 A/G cg07701084 chr6:150067640 NUP43 0.56 8.2 0.41 5.45e-15 Lung cancer; CRC cis rs10504229 1.000 rs116444534 chr8:58181915 A/G cg02725872 chr8:58115012 NA -0.41 -7.16 -0.37 5.35e-12 Developmental language disorder (linguistic errors); CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg11082575 chr12:31479096 FAM60A 0.5 6.42 0.33 4.76e-10 Thyroid stimulating hormone; CRC cis rs7552404 0.727 rs4949677 chr1:76266662 T/A cg22875332 chr1:76189707 ACADM 0.58 7.46 0.38 7.8e-13 Blood metabolite levels;Acylcarnitine levels; CRC cis rs4713118 0.662 rs9468275 chr6:28026136 G/T cg15786705 chr6:28176104 NA 0.69 9.22 0.45 3.64e-18 Parkinson's disease; CRC trans rs3942852 0.955 rs1910364 chr11:48113232 A/G cg15704280 chr7:45808275 SEPT13 -0.62 -7.31 -0.37 1.99e-12 Acute lymphoblastic leukemia (childhood); CRC cis rs2455601 0.638 rs2742484 chr11:8988083 G/A cg09997546 chr11:8931473 C11orf17;ST5 -0.43 -6.0 -0.31 5.19e-9 Schizophrenia; CRC cis rs9388451 0.868 rs1268083 chr6:126049040 T/C cg05901451 chr6:126070800 HEY2 0.56 9.35 0.46 1.36e-18 Brugada syndrome; CRC cis rs1577917 0.958 rs12208227 chr6:86670944 G/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.53 -6.96 -0.36 1.83e-11 Response to antipsychotic treatment; CRC cis rs10450586 0.863 rs7115024 chr11:27301437 G/A cg10370305 chr11:27303972 NA 0.37 6.08 0.32 3.41e-9 Total body bone mineral density; CRC cis rs2204008 0.744 rs12099650 chr12:38317140 C/G cg13010199 chr12:38710504 ALG10B 0.46 6.3 0.33 9.4e-10 Bladder cancer; CRC cis rs904251 0.698 rs2646926 chr6:37424988 G/A cg25019722 chr6:37503610 NA -0.37 -6.1 -0.32 2.96e-9 Cognitive performance; CRC trans rs2303319 0.504 rs62189041 chr2:162599506 T/C cg09481857 chr22:21368659 P2RX6;MGC16703 -0.65 -6.31 -0.33 9.13e-10 Cognitive function; CRC cis rs7647973 1.000 rs13088309 chr3:49368317 A/G cg07636037 chr3:49044803 WDR6 0.61 7.36 0.38 1.49e-12 Menarche (age at onset); CRC cis rs2979489 0.773 rs10954993 chr8:30303388 C/T cg26383811 chr8:30366931 RBPMS 0.69 9.68 0.47 1.12e-19 Mean corpuscular hemoglobin;Plateletcrit;Neutrophil count;Granulocyte count;Sum basophil neutrophil counts;Mean corpuscular volume;Myeloid white cell count;Sum neutrophil eosinophil counts; CRC cis rs9649213 0.593 rs6465682 chr7:98016417 C/A cg00277769 chr7:97922759 BAIAP2L1 -0.57 -9.74 -0.47 7.46e-20 Prostate cancer (SNP x SNP interaction); CRC cis rs473651 1.000 rs473651 chr2:239335401 A/C cg18131467 chr2:239335373 ASB1 1.02 23.53 0.79 1.79e-72 Multiple system atrophy; CRC cis rs60843830 1.000 rs7595075 chr2:264019 C/A cg00108164 chr2:264199 ACP1;SH3YL1 0.62 9.81 0.48 4.41e-20 Spherical equivalent (joint analysis main effects and education interaction); CRC cis rs6693567 0.545 rs4970922 chr1:150458094 C/A cg04165759 chr1:150448943 RPRD2 0.34 5.68 0.3 2.98e-8 Migraine; CRC cis rs6424115 0.679 rs2076345 chr1:24083494 C/T cg10978503 chr1:24200527 CNR2 -0.43 -6.39 -0.33 5.63e-10 Immature fraction of reticulocytes; CRC cis rs6912958 0.514 rs7767449 chr6:87887985 A/C cg12350822 chr6:88032061 C6orf162;GJB7 -0.46 -9.4 -0.46 9.71e-19 Monocyte percentage of white cells; CRC cis rs1190552 0.846 rs11160683 chr14:102933347 A/G cg18135206 chr14:102964638 TECPR2 0.51 6.19 0.32 1.76e-9 Blood protein levels; CRC cis rs2832191 0.791 rs2832182 chr21:30481612 G/A cg08807101 chr21:30365312 RNF160 -0.64 -10.44 -0.5 3.06e-22 Dental caries; CRC cis rs10540 1.000 rs12786555 chr11:506229 C/T cg15790184 chr11:494944 RNH1 0.6 6.17 0.32 1.95e-9 Body mass index; CRC cis rs6429082 0.871 rs6675944 chr1:235572669 C/T cg26050004 chr1:235667680 B3GALNT2 0.41 6.0 0.31 5.28e-9 Adiposity; CRC cis rs3785574 0.962 rs16947051 chr17:61790917 G/C cg06601766 chr17:61851465 DDX42;CCDC47 0.58 8.31 0.42 2.54e-15 Height; CRC cis rs11785400 1.000 rs4736342 chr8:143735190 A/G cg24634471 chr8:143751801 JRK 0.49 6.94 0.36 2.08e-11 Schizophrenia; CRC cis rs17767392 0.595 rs17177822 chr14:71656209 C/G cg13720639 chr14:72061746 SIPA1L1 -0.44 -5.66 -0.3 3.27e-8 Mitral valve prolapse; CRC cis rs9303280 0.806 rs12941333 chr17:38040534 C/T cg00129232 chr17:37814104 STARD3 -0.43 -6.9 -0.36 2.67e-11 Self-reported allergy; CRC cis rs4713118 0.666 rs4140646 chr6:27738801 G/A cg12273811 chr6:28175739 NA 0.51 5.71 0.3 2.51e-8 Parkinson's disease; CRC cis rs40363 0.671 rs4786425 chr16:3537650 A/G cg21433313 chr16:3507492 NAT15 -0.68 -6.57 -0.34 1.92e-10 Tuberculosis; CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg24511898 chr2:242576823 ATG4B;THAP4 -0.52 -6.46 -0.34 3.81e-10 Diisocyanate-induced asthma; CRC cis rs12050794 0.636 rs4506844 chr15:72509138 C/T cg16672083 chr15:72433130 SENP8 0.41 5.99 0.31 5.57e-9 Metabolite levels (HVA/MHPG ratio); CRC cis rs6951245 1.000 rs11766526 chr7:1101433 G/A cg26224354 chr7:1096374 C7orf50;GPR146 -0.93 -12.05 -0.55 5.9e-28 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs2274273 0.624 rs66464079 chr14:55766164 G/T cg10130446 chr14:55658398 DLGAP5 -0.4 -5.67 -0.3 3.14e-8 Protein biomarker; CRC cis rs9354352 0.935 rs9345749 chr6:66699892 G/T cg07460842 chr6:66804631 NA -0.58 -8.36 -0.42 1.8e-15 Initial pursuit acceleration in psychotic disorders; CRC cis rs2075371 0.933 rs1868785 chr7:133945855 G/C cg02659138 chr7:134003124 SLC35B4 0.38 6.51 0.34 2.78e-10 Mean platelet volume; CRC cis rs720844 0.684 rs7578059 chr2:149312470 G/A cg09247360 chr2:149335327 NA -0.58 -6.04 -0.32 4.12e-9 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs938554 0.513 rs11943372 chr4:9999346 T/A cg11266682 chr4:10021025 SLC2A9 0.35 6.23 0.32 1.4e-9 Blood metabolite levels; CRC cis rs4819052 0.788 rs9978857 chr21:46705155 T/G cg11663144 chr21:46675770 NA -0.68 -10.68 -0.51 4.68e-23 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs7705042 0.865 rs6580228 chr5:141510448 C/T cg08523384 chr5:141488047 NDFIP1 -0.33 -5.82 -0.31 1.43e-8 Asthma; CRC cis rs3741404 0.825 rs2515241 chr11:63975331 C/T cg05016508 chr11:63871570 FLRT1;MACROD1 0.42 6.42 0.33 4.68e-10 Platelet count; CRC cis rs7178572 1.000 rs1565756 chr15:77741640 G/A cg22256960 chr15:77711686 NA -0.71 -11.07 -0.52 2.02e-24 Type 2 diabetes; CRC cis rs4713118 0.513 rs149941 chr6:28001033 T/C cg12172441 chr6:28176163 NA 0.53 7.34 0.38 1.64e-12 Parkinson's disease; CRC cis rs6951245 1.000 rs80031817 chr7:1096793 T/C cg18402987 chr7:1209562 NA 0.67 7.15 0.37 5.54e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs7542091 0.704 rs12022221 chr1:210046178 A/C cg05527609 chr1:210001259 C1orf107 -0.44 -5.91 -0.31 8.38e-9 Monobrow; CRC cis rs2692947 0.526 rs4907225 chr2:96576670 C/T cg23100626 chr2:96804247 ASTL 0.27 7.18 0.37 4.68e-12 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg23394480 chr14:105487615 CDCA4 -0.41 -6.19 -0.32 1.84e-9 Myopia (pathological); CRC cis rs7772486 0.686 rs9390357 chr6:146129347 A/G cg23711669 chr6:146136114 FBXO30 0.68 11.5 0.54 5.78e-26 Lobe attachment (rater-scored or self-reported); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg02904365 chr1:6761379 DNAJC11 0.44 6.3 0.33 9.71e-10 Response to antipsychotic treatment; CRC cis rs10504229 1.000 rs34616626 chr8:58184650 C/T cg02290350 chr8:58132656 NA -0.42 -5.96 -0.31 6.62e-9 Developmental language disorder (linguistic errors); CRC cis rs4604732 0.536 rs78019731 chr1:247626430 C/T cg02104434 chr1:247694406 LOC148824;OR2C3 0.6 8.82 0.44 6.67e-17 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CRC cis rs2949837 0.581 rs1496499 chr7:45979023 T/G cg10677697 chr7:45961126 IGFBP3 0.35 6.1 0.32 2.92e-9 Sitting height ratio; CRC cis rs6963495 0.745 rs75805443 chr7:105162828 A/G cg02135003 chr7:105160482 PUS7 -0.9 -12.2 -0.56 1.71e-28 Bipolar disorder (body mass index interaction); CRC cis rs12597458 0.789 rs7186207 chr16:72035359 C/T cg01557791 chr16:72042693 DHODH -0.63 -9.96 -0.48 1.36e-20 Prostate cancer; CRC cis rs35883536 0.647 rs2783702 chr1:101040836 G/A cg06223162 chr1:101003688 GPR88 0.34 6.32 0.33 8.46e-10 Monocyte count; CRC cis rs6951245 1.000 rs78185558 chr7:1090183 G/C cg03188948 chr7:1209495 NA 0.58 6.24 0.33 1.33e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs6424115 0.931 rs11800561 chr1:24164398 T/G cg15997130 chr1:24165203 NA 0.71 11.02 0.52 2.95e-24 Immature fraction of reticulocytes; CRC cis rs4665809 1.000 rs2289022 chr2:26350136 G/T cg04944784 chr2:26401820 FAM59B -0.6 -7.67 -0.39 1.98e-13 Gut microbiome composition (summer); CRC cis rs8180040 0.966 rs13079098 chr3:47442863 A/G cg10298567 chr3:47292165 KIF9 -0.36 -5.96 -0.31 6.6e-9 Colorectal cancer; CRC cis rs10193935 1.000 rs10193935 chr2:42419829 C/T cg27598129 chr2:42591480 NA -0.66 -7.68 -0.39 1.8e-13 Colonoscopy-negative controls vs population controls; CRC cis rs4665809 0.590 rs6730310 chr2:26419470 C/G cg27170947 chr2:26402098 FAM59B -0.6 -7.69 -0.39 1.7e-13 Gut microbiome composition (summer); CRC cis rs2717559 0.683 rs2717611 chr8:143879927 C/T cg24046110 chr8:143859143 LYNX1 -0.54 -9.74 -0.47 7.55e-20 Urinary tract infection frequency; CRC cis rs427941 0.632 rs201493 chr7:101754865 T/C cg06246474 chr7:101738831 CUX1 0.42 6.33 0.33 7.92e-10 Plasma omega-3 polyunsaturated fatty acid level (eicosapentaenoic acid); CRC cis rs8062405 1.000 rs61737565 chr16:28855522 G/C cg08761264 chr16:28874980 SH2B1 -0.44 -5.84 -0.31 1.28e-8 Cognitive ability (multi-trait analysis);Cognitive ability; CRC cis rs6062302 0.522 rs6090475 chr20:62245397 C/A cg09650180 chr20:62225654 GMEB2 -0.51 -6.73 -0.35 7.63e-11 Glioblastoma; CRC cis rs10883723 0.773 rs715439 chr10:104257809 A/C cg11453585 chr10:104263688 ACTR1A;SUFU 0.92 17.68 0.7 1.2e-49 Allergic disease (asthma, hay fever or eczema); CRC cis rs1691799 0.863 rs1168291 chr12:66732488 T/C cg16791601 chr12:66731901 HELB -0.67 -11.29 -0.53 3.27e-25 White blood cell count (basophil); CRC cis rs17155006 0.746 rs419031 chr7:107750157 G/A cg05962710 chr7:107745446 LAMB4 -0.41 -7.33 -0.37 1.77e-12 Pneumococcal bacteremia; CRC cis rs8014204 0.836 rs12588415 chr14:75278211 G/A cg03030879 chr14:75389066 RPS6KL1 -0.51 -8.22 -0.41 4.87e-15 Caffeine consumption; CRC cis rs10197940 0.662 rs1047957 chr2:152333773 C/T cg19508488 chr2:152266495 RIF1 0.54 7.93 0.4 3.56e-14 Lung cancer; CRC cis rs4919694 0.572 rs7080935 chr10:104929113 C/A cg04362960 chr10:104952993 NT5C2 0.89 9.19 0.45 4.58e-18 Arsenic metabolism; CRC cis rs172166 0.694 rs1631552 chr6:28089699 C/A cg12172441 chr6:28176163 NA 0.52 7.21 0.37 3.9e-12 Cardiac Troponin-T levels; CRC cis rs17162190 0.685 rs7530096 chr1:26820218 G/A cg17456097 chr1:26900765 RPS6KA1 0.45 6.22 0.32 1.55e-9 Mean corpuscular volume; CRC cis rs6951245 1.000 rs11770909 chr7:1086716 G/A cg26224354 chr7:1096374 C7orf50;GPR146 -0.95 -11.9 -0.55 2.14e-27 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs9682041 0.877 rs12489967 chr3:170073339 A/C cg11886554 chr3:170076028 SKIL 0.69 8.07 0.41 1.32e-14 Glomerular filtration rate in non diabetics (creatinine);Glomerular filtration rate (creatinine); CRC trans rs208520 1.000 rs12193164 chr6:66978962 C/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.88 10.79 0.51 1.94e-23 Exhaled nitric oxide output; CRC cis rs10256972 0.521 rs7811577 chr7:1102829 C/G cg16145915 chr7:1198662 ZFAND2A -0.34 -6.88 -0.35 3.01e-11 Longevity;Endometriosis; CRC cis rs919433 0.817 rs10931780 chr2:198175297 G/C cg20885578 chr2:198174922 NA -0.41 -7.39 -0.38 1.24e-12 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC cis rs58688157 0.924 rs35865896 chr11:584591 A/G cg09218773 chr11:619014 MUPCDH -0.36 -5.67 -0.3 3.2e-8 Systemic lupus erythematosus; CRC cis rs11758351 0.660 rs11759904 chr6:26231443 T/C cg01420254 chr6:26195488 NA 0.73 8.07 0.41 1.31e-14 Gout;Renal underexcretion gout; CRC cis rs9368481 0.646 rs75843621 chr6:26967881 G/A cg05192639 chr6:26864778 GUSBL1 -0.35 -6.11 -0.32 2.79e-9 Autism spectrum disorder or schizophrenia; CRC cis rs7666738 0.830 rs10470894 chr4:99039107 G/A cg05340658 chr4:99064831 C4orf37 0.58 9.01 0.44 1.7e-17 Colonoscopy-negative controls vs population controls; CRC cis rs1577917 0.771 rs12199873 chr6:86294947 C/A cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.67 -8.79 -0.44 8.78e-17 Response to antipsychotic treatment; CRC cis rs950169 1.000 rs62026530 chr15:84775840 G/T cg03959625 chr15:84868606 LOC388152 0.42 6.36 0.33 6.88e-10 Schizophrenia; CRC cis rs6860806 0.507 rs2631372 chr5:131703578 C/G cg04518342 chr5:131593106 PDLIM4 0.44 7.22 0.37 3.59e-12 Breast cancer; CRC cis rs1957429 0.808 rs1467573 chr14:65347583 T/C cg23373153 chr14:65346875 NA 0.79 8.25 0.41 3.9e-15 Pediatric areal bone mineral density (radius); CRC cis rs7945705 0.837 rs2742474 chr11:9002089 A/G cg12365402 chr11:9010492 NRIP3 -0.57 -10.29 -0.49 1.01e-21 Hemoglobin concentration; CRC cis rs7831492 0.564 rs7831530 chr8:41614567 G/A cg17182837 chr8:41585554 ANK1 -0.64 -10.63 -0.51 7.03e-23 Colorectal cancer; CRC cis rs4555082 0.874 rs2735828 chr14:105710486 C/A cg13114125 chr14:105738426 BRF1 -0.76 -11.55 -0.54 3.93e-26 Mean platelet volume;Platelet distribution width; CRC trans rs17685 0.784 rs1637043 chr7:75699099 G/A cg19862616 chr7:65841803 NCRNA00174 1.0 18.97 0.72 1.01e-54 Coffee consumption;Coffee consumption (cups per day); CRC cis rs7932354 0.528 rs1060573 chr11:47179829 A/G cg03339077 chr11:47165057 C11orf49 0.46 6.44 0.33 4.28e-10 Bone mineral density (hip);Bone mineral density; CRC cis rs704795 0.836 rs1083865 chr2:27620827 A/G cg12000995 chr2:27665139 KRTCAP3 -0.31 -6.43 -0.33 4.54e-10 Menopause (age at onset); CRC cis rs6460942 1.000 rs117657017 chr7:12318891 T/C cg06484146 chr7:12443880 VWDE -0.76 -7.52 -0.38 5.36e-13 Coronary artery disease; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg15805921 chr6:42952109 PPP2R5D 0.44 6.41 0.33 5.12e-10 Response to antipsychotic treatment; CRC cis rs7940866 0.903 rs1433980 chr11:130870956 A/G cg12179176 chr11:130786555 SNX19 0.58 8.78 0.44 9.41e-17 Schizophrenia; CRC cis rs4319547 0.656 rs10734918 chr12:122921512 A/C cg05707623 chr12:122985044 ZCCHC8 -0.73 -9.2 -0.45 4.31e-18 Body mass index; CRC cis rs7666738 0.830 rs1426666 chr4:99030887 A/G cg17366294 chr4:99064904 C4orf37 0.44 7.48 0.38 6.96e-13 Colonoscopy-negative controls vs population controls; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg08089702 chr22:21822289 NA 0.48 6.83 0.35 4.2e-11 Response to antipsychotic treatment; CRC cis rs12950390 0.853 rs56363619 chr17:45854621 T/C cg24803719 chr17:45855879 NA -0.31 -6.92 -0.36 2.34e-11 IgG glycosylation; CRC cis rs3762318 1.000 rs3762318 chr1:67597119 A/G cg17031739 chr1:67600172 NA -0.5 -6.01 -0.31 4.82e-9 Leprosy; CRC cis rs7926971 0.756 rs4633453 chr11:12660424 C/G cg25843174 chr11:12811716 TEAD1 -0.33 -6.05 -0.32 4.02e-9 Height; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg01594214 chr6:123110554 SMPDL3A -0.41 -6.09 -0.32 3.16e-9 Myopia (pathological); CRC cis rs6952808 1.000 rs6954673 chr7:1886937 C/T cg20295408 chr7:1910781 MAD1L1 -0.45 -6.25 -0.33 1.27e-9 Bipolar disorder and schizophrenia; CRC cis rs908922 0.676 rs11581947 chr1:152482587 G/A cg09873164 chr1:152488093 CRCT1 0.34 5.74 0.3 2.16e-8 Hair morphology; CRC trans rs208520 0.837 rs208489 chr6:66927584 G/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.93 -12.01 -0.55 8.16e-28 Exhaled nitric oxide output; CRC cis rs12701220 0.572 rs7792825 chr7:1006573 T/C cg26769984 chr7:1090371 C7orf50 0.47 6.83 0.35 4.19e-11 Bronchopulmonary dysplasia; CRC cis rs798554 0.757 rs1182178 chr7:2873763 G/A cg14863265 chr7:2801509 GNA12 -0.41 -5.62 -0.3 4.02e-8 Height; CRC cis rs9372253 1.000 rs2235989 chr6:110714584 A/T cg01119278 chr6:110721349 DDO -0.39 -6.31 -0.33 9.05e-10 Platelet distribution width; CRC cis rs11711311 1.000 rs9830978 chr3:113455940 A/C cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.52 -7.0 -0.36 1.47e-11 IgG glycosylation; CRC cis rs9660180 0.967 rs11260623 chr1:1781456 G/T cg13866156 chr1:1669148 SLC35E2 -0.61 -9.3 -0.46 1.95e-18 Body mass index; CRC cis rs9463078 0.774 rs3923353 chr6:45256482 C/G cg25276700 chr6:44698697 NA -0.27 -6.45 -0.33 4.11e-10 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; CRC cis rs703842 0.575 rs701006 chr12:58106836 C/T cg18357645 chr12:58087776 OS9 -0.5 -7.0 -0.36 1.48e-11 Multiple sclerosis; CRC cis rs2404602 0.716 rs12438077 chr15:76863601 T/C cg23625390 chr15:77176239 SCAPER 0.47 6.85 0.35 3.61e-11 Blood metabolite levels; CRC trans rs703108 0.731 rs7898954 chr10:22323646 A/G cg13970591 chr19:1491289 REEP6;PCSK4 -0.53 -6.24 -0.33 1.35e-9 Monocyte percentage of white cells; CRC trans rs2727020 0.658 rs7111215 chr11:49430552 T/C cg15704280 chr7:45808275 SEPT13 -0.91 -17.24 -0.69 6.89e-48 Coronary artery disease; CRC cis rs736408 0.609 rs2230535 chr3:52800284 T/C cg18404041 chr3:52824283 ITIH1 -0.43 -8.7 -0.43 1.66e-16 Bipolar disorder; CRC cis rs2732480 0.500 rs7966829 chr12:48615603 G/T cg21466736 chr12:48725269 NA -0.52 -7.93 -0.4 3.39e-14 Hemoglobin concentration;Red blood cell count;Hematocrit; CRC trans rs7615952 0.546 rs2979333 chr3:125360343 T/A cg16558177 chr4:4109446 NA -0.56 -6.7 -0.35 8.94e-11 Blood pressure (smoking interaction); CRC cis rs6545883 0.783 rs7579651 chr2:61800279 C/G cg15711740 chr2:61764176 XPO1 -0.53 -7.21 -0.37 3.75e-12 Tuberculosis; CRC cis rs2439831 0.702 rs3784275 chr15:44091386 G/A cg02155558 chr15:43621948 ADAL;LCMT2 0.77 6.91 0.36 2.53e-11 Lung cancer in ever smokers; CRC cis rs1552244 1.000 rs9809061 chr3:10085130 C/G cg16606324 chr3:10149918 C3orf24 0.7 9.66 0.47 1.31e-19 Alzheimer's disease; CRC cis rs1865721 0.804 rs72977816 chr18:73146779 A/T cg26385618 chr18:73139727 C18orf62 -0.4 -5.68 -0.3 2.97e-8 Intelligence; CRC cis rs798554 0.757 rs2533878 chr7:2878707 A/G cg14895029 chr7:2775587 GNA12 0.43 6.15 0.32 2.21e-9 Height; CRC cis rs7772486 0.790 rs2249147 chr6:146184999 T/C cg23711669 chr6:146136114 FBXO30 0.68 11.46 0.53 8.58e-26 Lobe attachment (rater-scored or self-reported); CRC trans rs35110281 0.720 rs162394 chr21:44943550 C/G cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO -0.49 -8.05 -0.41 1.55e-14 Mean corpuscular volume; CRC cis rs3767633 0.925 rs1553444 chr1:161813515 C/T cg09175582 chr1:161736000 ATF6 0.66 6.0 0.31 5.14e-9 IgG glycosylation; CRC cis rs1801251 0.778 rs709934 chr2:233733352 A/G cg25237894 chr2:233734115 C2orf82 -0.63 -11.25 -0.53 4.52e-25 Coronary artery disease; CRC cis rs10504229 0.683 rs2318144 chr8:58114743 G/A cg21724239 chr8:58056113 NA 0.74 9.36 0.46 1.27e-18 Developmental language disorder (linguistic errors); CRC cis rs4803480 0.678 rs3745936 chr19:42092815 T/A cg08478046 chr19:42093086 CEACAM21 -0.31 -6.08 -0.32 3.34e-9 Schizophrenia; CRC cis rs9457247 0.715 rs6923582 chr6:167437162 T/A cg07741184 chr6:167504864 NA 0.38 6.54 0.34 2.33e-10 Crohn's disease; CRC cis rs10504229 0.775 rs17805110 chr8:58161439 C/G cg11062466 chr8:58055876 NA -0.44 -5.81 -0.3 1.51e-8 Developmental language disorder (linguistic errors); CRC cis rs10504229 0.511 rs16921553 chr8:57979314 T/C cg21724239 chr8:58056113 NA 0.47 5.91 0.31 8.44e-9 Developmental language disorder (linguistic errors); CRC cis rs61774743 0.557 rs4359027 chr1:41848296 G/A cg01193554 chr1:41846683 NA -0.38 -6.09 -0.32 3.13e-9 Intelligence (multi-trait analysis); CRC trans rs916888 0.821 rs199512 chr17:44857352 T/C cg23590916 chr17:43697445 MGC57346 -0.57 -6.14 -0.32 2.32e-9 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs7617480 0.648 rs9859473 chr3:48837182 A/G cg07636037 chr3:49044803 WDR6 0.84 10.5 0.5 1.99e-22 Subjective well-being (multi-trait analysis);Menarche (age at onset); CRC cis rs9467773 1.000 rs9393729 chr6:26514166 C/T cg09904177 chr6:26538194 HMGN4 0.86 14.68 0.63 7.08e-38 Intelligence (multi-trait analysis); CRC cis rs7811142 1.000 rs60478351 chr7:100089017 C/T cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.93 12.29 0.56 8.1e-29 Platelet count; CRC cis rs3733585 0.699 rs7435196 chr4:9967556 A/C cg11266682 chr4:10021025 SLC2A9 -0.47 -9.74 -0.47 7.21e-20 Cleft plate (environmental tobacco smoke interaction); CRC cis rs5498 0.809 rs62130684 chr19:10408427 C/T cg10604476 chr19:10403908 ICAM5 0.3 5.66 0.3 3.21e-8 Lymphocyte counts;Soluble ICAM-1;Blood protein levels; CRC cis rs1448094 0.556 rs17345522 chr12:86169929 T/C cg06740227 chr12:86229804 RASSF9 0.39 5.86 0.31 1.09e-8 Major depressive disorder; CRC cis rs769267 0.896 rs2315610 chr19:19597240 T/C cg03709012 chr19:19516395 GATAD2A 0.72 11.23 0.53 5.46e-25 Tonsillectomy; CRC cis rs524023 1.000 rs9734313 chr11:64358311 C/T cg06522879 chr11:64358276 SLC22A12 -0.59 -9.38 -0.46 1.11e-18 Urate levels in obese individuals; CRC cis rs17270561 0.609 rs12192077 chr6:25732794 G/A cg16482183 chr6:26056742 HIST1H1C 0.83 10.58 0.5 1.07e-22 Iron status biomarkers; CRC cis rs7197653 0.748 rs8060690 chr16:68340085 G/T cg05110241 chr16:68378359 PRMT7 -0.76 -7.53 -0.38 4.91e-13 Magnesium levels; CRC cis rs2274273 0.624 rs67795323 chr14:55797833 G/A cg10130446 chr14:55658398 DLGAP5 -0.41 -5.74 -0.3 2.21e-8 Protein biomarker; CRC trans rs8108034 1.000 rs39587 chr19:39806997 C/T cg15120146 chr6:42897303 CNPY3 -0.56 -6.1 -0.32 3.04e-9 Lung adenocarcinoma; CRC cis rs1707322 1.000 rs11211223 chr1:46380605 C/T cg03146154 chr1:46216737 IPP 0.52 7.15 0.37 5.72e-12 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs3125734 0.633 rs4979774 chr10:63967795 A/T cg19640130 chr10:64028056 RTKN2 -0.34 -5.6 -0.3 4.51e-8 Rheumatoid arthritis; CRC cis rs10751667 0.666 rs11246358 chr11:967349 G/A cg06064525 chr11:970664 AP2A2 -0.34 -6.84 -0.35 3.97e-11 Alzheimer's disease (late onset); CRC cis rs4716602 0.596 rs12386634 chr7:156158373 G/A cg16983916 chr7:156159713 NA -0.39 -6.91 -0.36 2.45e-11 Anti-saccade response; CRC trans rs4263408 0.934 rs9683743 chr4:39703194 A/C cg16794633 chr3:143690145 C3orf58 -0.43 -6.47 -0.34 3.61e-10 Plasma amyloid beta peptide concentrations (ABx-40); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg05477933 chr12:54426537 HOXC4;HOXC5 0.47 6.64 0.34 1.33e-10 Response to antipsychotic treatment; CRC cis rs1434579 0.966 rs1062098 chr19:44930738 A/G cg15540054 chr19:45004280 ZNF180 0.48 6.11 0.32 2.76e-9 Tuberculosis; CRC cis rs9858542 0.903 rs11921590 chr3:49644193 T/C cg03060546 chr3:49711283 APEH -0.49 -6.49 -0.34 3.19e-10 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs8114671 0.562 rs6087651 chr20:33518353 C/T cg07148914 chr20:33460835 GGT7 0.4 6.63 0.34 1.38e-10 Height; CRC cis rs3768617 0.706 rs6678517 chr1:183002639 A/G ch.1.3577855R chr1:183094577 LAMC1 0.65 10.03 0.48 8.13e-21 Fuchs's corneal dystrophy; CRC cis rs9326248 1.000 rs664922 chr11:117070895 C/A cg10130564 chr11:117069849 TAGLN 0.38 7.1 0.36 7.69e-12 Blood protein levels; CRC trans rs7615952 0.736 rs9866347 chr3:125669925 C/T cg02560186 chr11:3602584 NA -0.5 -5.99 -0.31 5.46e-9 Blood pressure (smoking interaction); CRC cis rs7659604 0.967 rs34949254 chr4:122664344 G/A cg20573242 chr4:122745356 CCNA2 0.41 6.1 0.32 3.01e-9 Type 2 diabetes; CRC cis rs4664293 0.867 rs12620924 chr2:160602963 G/A cg08347373 chr2:160653686 CD302 -0.47 -7.52 -0.38 5.32e-13 Monocyte percentage of white cells; CRC cis rs6714710 0.603 rs2044458 chr2:98377512 A/T cg26665480 chr2:98280029 ACTR1B 0.5 6.94 0.36 2.05e-11 Posterior cortical atrophy and Alzheimer's disease; CRC cis rs936229 0.668 rs67411922 chr15:75187612 A/G cg14664628 chr15:75095509 CSK -0.85 -14.46 -0.62 4.99e-37 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); CRC cis rs1153858 1.000 rs66939267 chr15:45676902 T/A cg21132104 chr15:45694354 SPATA5L1 0.57 8.29 0.42 2.85e-15 Homoarginine levels; CRC cis rs853679 0.517 rs9348796 chr6:28126202 A/G cg25164649 chr6:28176230 NA 0.78 9.66 0.47 1.33e-19 Depression; CRC cis rs6502050 0.835 rs4789732 chr17:80131382 A/G cg13198984 chr17:80129470 CCDC57 0.46 8.13 0.41 9e-15 Life satisfaction; CRC cis rs360798 0.512 rs4461246 chr2:63027671 C/T cg17519650 chr2:63277830 OTX1 -0.43 -6.26 -0.33 1.22e-9 Coronary artery disease; CRC cis rs9325144 0.647 rs11169189 chr12:39097078 A/T cg26384229 chr12:38710491 ALG10B -0.5 -6.92 -0.36 2.31e-11 Morning vs. evening chronotype; CRC cis rs6499255 0.951 rs12232410 chr16:69736851 G/A cg15192750 chr16:69999425 NA 0.47 6.57 0.34 2e-10 IgE levels; CRC cis rs185694 1.000 rs613291 chr13:30894404 T/C cg04551440 chr13:30881194 KATNAL1 -0.63 -6.5 -0.34 2.97e-10 Antineutrophil cytoplasmic antibody-associated vasculitis; CRC cis rs9303280 0.651 rs59716545 chr17:38031857 T/G cg00129232 chr17:37814104 STARD3 -0.47 -7.39 -0.38 1.25e-12 Self-reported allergy; CRC cis rs231513 0.911 rs231476 chr17:41985845 A/G cg26893861 chr17:41843967 DUSP3 -0.63 -6.05 -0.32 4.02e-9 Cognitive function; CRC cis rs875971 0.502 rs6460311 chr7:66111873 C/T cg18876405 chr7:65276391 NA -0.46 -6.3 -0.33 9.31e-10 Aortic root size; CRC cis rs3764400 0.567 rs208012 chr17:46258017 G/A cg10706073 chr17:46328419 SKAP1 0.59 6.55 0.34 2.21e-10 Body mass index; CRC cis rs7119 0.667 rs4886889 chr15:77902347 T/C cg27398640 chr15:77910606 LINGO1 0.44 8.08 0.41 1.26e-14 Type 2 diabetes; CRC cis rs2249694 0.919 rs11101867 chr10:135400250 C/T cg16964102 chr10:135390573 NA 0.45 7.61 0.39 2.9e-13 Obesity-related traits; CRC cis rs6582630 0.555 rs34145279 chr12:38405588 T/C cg26384229 chr12:38710491 ALG10B 0.69 9.19 0.45 4.52e-18 Drug-induced liver injury (flucloxacillin); CRC trans rs7395662 0.963 rs12800770 chr11:48604927 T/G cg21153622 chr11:89784906 NA -0.47 -7.53 -0.38 4.94e-13 HDL cholesterol; CRC trans rs7726839 0.540 rs4957083 chr5:659343 T/C cg25482853 chr8:67687455 SGK3 1.12 13.05 0.58 1.19e-31 Obesity-related traits; CRC trans rs11800820 0.595 rs3124127 chr1:246710987 C/T cg26885821 chr6:124125002 NKAIN2 0.37 6.04 0.32 4.26e-9 Obesity-related traits; CRC cis rs2976388 0.609 rs2585150 chr8:143792669 C/T cg05569086 chr8:143859399 LYNX1 0.4 6.96 0.36 1.91e-11 Urinary tract infection frequency; CRC cis rs79839061 0.610 rs1564282 chr4:852313 C/T cg14530993 chr4:882597 GAK 0.83 7.53 0.38 4.82e-13 Intelligence (multi-trait analysis); CRC trans rs9858542 1.000 rs4283605 chr3:49678651 A/G cg21582582 chr3:182698605 DCUN1D1 -0.57 -6.99 -0.36 1.57e-11 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs6565180 0.926 rs4788409 chr16:30393771 G/A cg17640201 chr16:30407289 ZNF48 0.84 13.94 0.61 4.86e-35 Tonsillectomy; CRC cis rs2404602 0.692 rs12902452 chr15:76921465 T/C cg03037974 chr15:76606532 NA 0.69 12.16 0.56 2.4e-28 Blood metabolite levels; CRC cis rs4253772 0.638 rs6007845 chr22:46718417 A/T cg24881330 chr22:46731750 TRMU -0.72 -8.37 -0.42 1.71e-15 LDL cholesterol;Cholesterol, total; CRC cis rs2032447 0.899 rs1090947 chr6:26076642 T/C cg12588279 chr6:26043732 HIST1H2BB 0.41 5.95 0.31 6.88e-9 Intelligence (multi-trait analysis); CRC cis rs1707322 0.721 rs10430123 chr1:46221440 T/C cg03146154 chr1:46216737 IPP 0.68 9.94 0.48 1.59e-20 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs9916302 0.851 rs9904919 chr17:37556431 G/C cg03013999 chr17:37608204 MED1 -0.47 -7.21 -0.37 3.87e-12 Glomerular filtration rate (creatinine); CRC cis rs1552244 0.515 rs67626468 chr3:10161518 C/A cg00166722 chr3:10149974 C3orf24 0.65 7.69 0.39 1.73e-13 Alzheimer's disease; CRC cis rs2386661 0.712 rs11259544 chr10:5646708 T/C cg12223502 chr10:5658492 NA -0.35 -5.71 -0.3 2.51e-8 Breast cancer; CRC cis rs9814567 0.929 rs13316205 chr3:134223563 G/A cg06109529 chr3:134205091 CEP63;ANAPC13 -0.8 -11.99 -0.55 9.67e-28 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs1552244 0.935 rs35515831 chr3:10071362 G/A cg02579736 chr3:10068473 FANCD2;CIDECP 0.96 12.65 0.57 3.81e-30 Alzheimer's disease; CRC cis rs12497850 0.931 rs13315711 chr3:48986399 A/T cg20833759 chr3:49053208 WDR6;DALRD3 0.54 9.36 0.46 1.32e-18 Parkinson's disease; CRC cis rs7524258 0.903 rs4908449 chr1:7292700 T/C cg07173049 chr1:7289937 CAMTA1 0.67 10.67 0.51 4.99e-23 Tourette's syndrome or obsessive-compulsive disorder; CRC cis rs1355223 0.867 rs2281908 chr11:34683578 C/T cg11058730 chr11:34937778 PDHX;APIP -0.41 -5.67 -0.3 3.18e-8 Systemic lupus erythematosus and Systemic sclerosis; CRC cis rs2281845 0.533 rs112365857 chr1:201097222 G/C cg24849736 chr1:201084428 NA 0.5 6.82 0.35 4.51e-11 Permanent tooth development; CRC cis rs9462027 0.675 rs34657938 chr6:34801631 A/G cg07306190 chr6:34760872 UHRF1BP1 -0.34 -6.09 -0.32 3.16e-9 Systemic lupus erythematosus; CRC cis rs17376456 0.877 rs28575883 chr5:93346035 T/C cg21475434 chr5:93447410 FAM172A 0.79 7.9 0.4 4.24e-14 Diabetic retinopathy; CRC cis rs5753618 0.561 rs9609254 chr22:31705942 G/A cg22777020 chr22:31556080 RNF185 0.55 6.28 0.33 1.08e-9 Colorectal cancer; CRC trans rs208520 0.526 rs1385219 chr6:66754476 C/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 1.1 21.03 0.76 7.79e-63 Exhaled nitric oxide output; CRC cis rs4604732 0.527 rs12031949 chr1:247624463 G/T cg12758973 chr1:247694275 LOC148824;OR2C3 0.42 6.19 0.32 1.75e-9 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CRC cis rs9311474 0.507 rs4687644 chr3:52746541 T/G cg11645453 chr3:52864694 ITIH4 0.37 6.53 0.34 2.57e-10 Electroencephalogram traits; CRC cis rs62244186 0.566 rs55901755 chr3:44834707 C/T cg10263370 chr3:44754102 ZNF502 -0.36 -6.08 -0.32 3.31e-9 Depressive symptoms; CRC cis rs40363 0.645 rs250633 chr16:3523002 C/T cg21433313 chr16:3507492 NAT15 0.56 8.4 0.42 1.33e-15 Tuberculosis; CRC cis rs1003719 0.646 rs7276711 chr21:38578189 G/A cg10648535 chr21:38446584 PIGP;TTC3 -0.45 -6.23 -0.32 1.41e-9 Eye color traits; CRC cis rs6752107 0.967 rs3792111 chr2:234179690 C/T cg07618928 chr2:234183455 ATG16L1;SCARNA5 0.65 11.11 0.52 1.46e-24 Crohn's disease;Inflammatory bowel disease; CRC cis rs4148883 0.603 rs6833176 chr4:100131163 G/C cg12011299 chr4:100065546 ADH4 -0.41 -8.72 -0.43 1.42e-16 Alcohol dependence; CRC cis rs11997175 0.524 rs10954932 chr8:33650176 A/C cg04338863 chr8:33670619 NA 0.4 6.84 0.35 3.8e-11 Body mass index; CRC cis rs875971 0.862 rs2420174 chr7:65645361 C/T cg18876405 chr7:65276391 NA -0.53 -8.85 -0.44 5.57e-17 Aortic root size; CRC cis rs747650 0.504 rs11039080 chr11:47093084 T/C cg19486271 chr11:47235900 DDB2 0.44 5.86 0.31 1.11e-8 Acne (severe); CRC cis rs4665809 0.556 rs6730311 chr2:26419474 C/T cg08067268 chr2:26466485 HADHB;HADHA -0.64 -8.24 -0.41 4.21e-15 Gut microbiome composition (summer); CRC cis rs2832191 0.671 rs2832212 chr21:30511417 G/A cg24692254 chr21:30365293 RNF160 -0.57 -8.37 -0.42 1.64e-15 Dental caries; CRC cis rs2204008 0.774 rs2387811 chr12:38369794 C/A cg26384229 chr12:38710491 ALG10B 0.69 9.23 0.45 3.47e-18 Bladder cancer; CRC cis rs9399135 0.967 rs4142299 chr6:135377186 G/T cg24558204 chr6:135376177 HBS1L 0.49 7.57 0.39 3.72e-13 Red blood cell count; CRC cis rs7224737 1.000 rs8074708 chr17:40286354 A/G cg20291162 chr17:40259547 DHX58 0.55 8.07 0.41 1.29e-14 Fibrinogen levels; CRC cis rs877282 0.945 rs877280 chr10:771599 C/T cg17470449 chr10:769945 NA 0.64 8.69 0.43 1.78e-16 Uric acid levels; CRC cis rs9611565 0.649 rs9623450 chr22:42175231 G/A cg03806693 chr22:41940476 POLR3H 0.68 9.46 0.46 6.05e-19 Vitiligo; CRC cis rs7786808 0.615 rs4909209 chr7:158194329 C/T cg09998033 chr7:158218633 PTPRN2 -0.58 -7.99 -0.4 2.25e-14 Obesity-related traits; CRC cis rs7617773 0.817 rs3937 chr3:48312402 T/C cg11946769 chr3:48343235 NME6 0.63 8.67 0.43 2.02e-16 Coronary artery disease; CRC cis rs593982 0.925 rs603509 chr11:65507605 C/T cg08755490 chr11:65554678 OVOL1 -1.17 -18.5 -0.71 6.94e-53 Atopic dermatitis; CRC cis rs9467711 0.606 rs34550936 chr6:26361985 A/G cg14345882 chr6:26364793 BTN3A2 0.64 5.63 0.3 3.85e-8 Autism spectrum disorder or schizophrenia; CRC cis rs375066 0.592 rs349047 chr19:44300884 G/A cg12072164 chr19:44306565 LYPD5 -0.39 -6.3 -0.33 9.43e-10 Breast cancer; CRC trans rs6703335 0.870 rs10803142 chr1:243598234 A/G cg01045622 chr10:79686064 LOC100128292;DLG5 0.43 6.03 0.32 4.29e-9 Schizophrenia;Schizophrenia, schizoaffective disorder or bipolar disorder; CRC cis rs1580019 0.587 rs2392069 chr7:32547154 A/G cg06627557 chr7:32535165 LSM5;AVL9 0.97 18.91 0.72 1.7e-54 Cognitive ability; CRC cis rs6062302 0.522 rs914558 chr20:62216976 A/G cg16989086 chr20:62203971 PRIC285 0.46 5.93 0.31 7.87e-9 Glioblastoma; CRC cis rs8180040 0.701 rs13066214 chr3:47033937 C/T cg27129171 chr3:47204927 SETD2 0.68 11.15 0.52 1.09e-24 Colorectal cancer; CRC cis rs1129187 0.720 rs9471972 chr6:42915021 G/A cg10862848 chr6:42927986 GNMT -0.37 -8.82 -0.44 6.68e-17 Alzheimer's disease in APOE e4+ carriers; CRC cis rs1712517 0.873 rs7903004 chr10:105004101 G/A cg05636881 chr10:105038444 INA -0.47 -8.34 -0.42 2.11e-15 Migraine; CRC cis rs561341 0.714 rs111760509 chr17:30304320 A/G cg00745463 chr17:30367425 LRRC37B -0.88 -9.56 -0.47 2.87e-19 Hip circumference adjusted for BMI; CRC cis rs2072499 0.931 rs1052053 chr1:156202173 A/G cg06970220 chr1:156163860 SLC25A44 0.43 6.24 0.33 1.35e-9 Testicular germ cell tumor; CRC cis rs28386778 0.863 rs4968661 chr17:61796306 A/G cg25654072 chr17:61904446 PSMC5;FTSJ3 0.7 10.67 0.51 4.95e-23 Prudent dietary pattern; CRC cis rs1975974 1.000 rs4889732 chr17:21721443 T/C cg18423549 chr17:21743878 NA -0.64 -8.99 -0.44 1.99e-17 Psoriasis; CRC cis rs9311474 0.508 rs4687629 chr3:52615227 G/C cg15147215 chr3:52552868 STAB1 -0.63 -10.98 -0.52 4.02e-24 Electroencephalogram traits; CRC cis rs4237845 0.804 rs11172372 chr12:58286273 T/C cg02175503 chr12:58329896 NA 0.59 8.37 0.42 1.64e-15 Intelligence (multi-trait analysis); CRC cis rs6582630 0.555 rs56228141 chr12:38518652 T/G cg26384229 chr12:38710491 ALG10B 0.71 10.06 0.48 6.25e-21 Drug-induced liver injury (flucloxacillin); CRC cis rs4481887 0.741 rs28468416 chr1:248564451 G/T cg26353448 chr1:248524236 OR2T4 -0.3 -5.63 -0.3 3.78e-8 Common traits (Other); CRC cis rs9611565 0.921 rs5751081 chr22:41742788 A/T cg06634786 chr22:41940651 POLR3H -0.41 -5.81 -0.31 1.45e-8 Vitiligo; CRC cis rs62158211 0.955 rs1823125 chr2:114090412 C/T cg17784749 chr2:114082611 LOC440839 -0.55 -6.59 -0.34 1.8e-10 Sleep duration (oversleepers vs undersleepers);Sleep traits (multi-trait analysis);Sleep duration; CRC cis rs3093024 1.000 rs3093024 chr6:167532793 C/T cg07741184 chr6:167504864 NA 0.39 6.98 0.36 1.61e-11 Rheumatoid arthritis; CRC cis rs2012796 0.956 rs7146802 chr14:81820515 A/G cg02996355 chr14:81879375 NA 0.5 7.32 0.37 1.9e-12 Night sleep phenotypes; CRC cis rs8077889 0.956 rs61608877 chr17:41848713 A/C cg26893861 chr17:41843967 DUSP3 0.9 12.93 0.58 3.34e-31 Triglycerides; CRC cis rs10504229 1.000 rs58382845 chr8:58169851 A/C cg01721255 chr8:58191610 C8orf71 0.49 6.08 0.32 3.29e-9 Developmental language disorder (linguistic errors); CRC cis rs72634258 0.732 rs6577464 chr1:8171302 T/C cg26816564 chr1:7831052 VAMP3 -0.48 -5.76 -0.3 1.97e-8 Inflammatory bowel disease; CRC cis rs11608355 0.515 rs7136048 chr12:109903926 A/G cg05360138 chr12:110035743 NA 0.77 8.7 0.43 1.65e-16 Neuroticism; CRC cis rs34172651 0.583 rs200541 chr16:24733141 A/G cg02428538 chr16:24856791 SLC5A11 0.63 7.18 0.37 4.61e-12 Intelligence (multi-trait analysis); CRC cis rs10504229 0.595 rs116490935 chr8:58117531 A/G cg05313129 chr8:58192883 C8orf71 -0.43 -5.95 -0.31 7.03e-9 Developmental language disorder (linguistic errors); CRC cis rs860295 0.702 rs34124416 chr1:155578049 C/G cg02153340 chr1:155202674 NA -0.51 -6.37 -0.33 6.34e-10 Body mass index; CRC cis rs743757 0.878 rs1467913 chr3:50525017 G/T cg09545109 chr3:50388910 TUSC4;CYB561D2 0.43 6.14 0.32 2.41e-9 Diastolic blood pressure; CRC cis rs769267 1.000 rs2074089 chr19:19449603 G/A cg02546618 chr19:19431379 KIAA0892;SF4 -0.46 -6.45 -0.34 3.92e-10 Tonsillectomy; CRC cis rs4604732 0.631 rs1106721 chr1:247624676 A/C cg12754571 chr1:247694271 LOC148824;OR2C3 0.41 5.79 0.3 1.64e-8 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CRC cis rs951366 0.903 rs708723 chr1:205739266 C/T cg26354017 chr1:205819088 PM20D1 0.46 6.79 0.35 5.23e-11 Menarche (age at onset); CRC cis rs9811920 0.570 rs1021102 chr3:99603780 T/A cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G 0.46 6.18 0.32 1.87e-9 Axial length; CRC cis rs11098499 0.691 rs9995716 chr4:120264996 T/C cg09307838 chr4:120376055 NA 0.61 9.54 0.47 3.35e-19 Corneal astigmatism; CRC cis rs9399135 0.967 rs2297340 chr6:135376058 T/C cg24558204 chr6:135376177 HBS1L 0.49 7.75 0.39 1.17e-13 Red blood cell count; CRC cis rs6456156 0.586 rs1407315 chr6:167468659 A/G cg07741184 chr6:167504864 NA 0.39 6.85 0.35 3.59e-11 Primary biliary cholangitis; CRC cis rs11971779 0.715 rs10265 chr7:139026152 T/G cg23387468 chr7:139079360 LUC7L2 0.4 7.14 0.37 5.84e-12 Diisocyanate-induced asthma; CRC cis rs4076764 0.914 rs6704467 chr1:163364512 A/G cg06092702 chr1:163392909 NA -0.54 -8.53 -0.43 5.46e-16 Motion sickness; CRC cis rs908922 0.676 rs6587686 chr1:152528948 C/T cg09873164 chr1:152488093 CRCT1 0.36 6.13 0.32 2.48e-9 Hair morphology; CRC cis rs7914558 1.000 rs7899084 chr10:104872547 A/T cg15744005 chr10:104629667 AS3MT -0.34 -7.31 -0.37 2.1e-12 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs743757 0.816 rs6792502 chr3:50531201 C/A cg09545109 chr3:50388910 TUSC4;CYB561D2 0.45 6.31 0.33 9.24e-10 Diastolic blood pressure; CRC cis rs9467160 0.520 rs9379660 chr6:24441635 C/G cg20631270 chr6:24437470 GPLD1 0.45 7.13 0.37 6.46e-12 Liver enzyme levels; CRC cis rs747650 0.884 rs7128325 chr11:47046554 G/A cg03339077 chr11:47165057 C11orf49 0.44 6.08 0.32 3.36e-9 Acne (severe); CRC cis rs711830 1.000 rs1051929 chr2:177036754 T/C cg13092806 chr2:177043255 NA 0.73 9.19 0.45 4.62e-18 Serous invasive ovarian cancer;Epithelial ovarian cancer;Invasive epithelial ovarian cancer;Mucinous ovarian carcinoma;Low-grade serous and serous borderline ovarian cancer;Serous borderline ovarian cancer;High-grade serous ovarian cancer; CRC cis rs2658782 0.789 rs2605574 chr11:93136444 T/G cg15737290 chr11:93063684 CCDC67 0.42 6.56 0.34 2.04e-10 Pulmonary function decline; CRC cis rs12681288 0.823 rs2701908 chr8:1003250 T/C cg04851639 chr8:1020857 NA -0.38 -7.93 -0.4 3.53e-14 Schizophrenia; CRC cis rs2617583 0.530 rs905201 chr5:1457986 C/T cg07148919 chr5:1466943 LPCAT1 -0.42 -5.72 -0.3 2.39e-8 Breast cancer; CRC cis rs2033711 0.728 rs4801586 chr19:58934528 A/G cg00825309 chr19:58991885 ZNF446 -0.46 -6.71 -0.35 8.75e-11 Uric acid clearance; CRC cis rs864537 0.618 rs2988277 chr1:167431352 A/G cg09179987 chr1:167433047 CD247 -0.53 -7.83 -0.4 6.75e-14 Celiac disease or Rheumatoid arthritis;Celiac disease; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg03982443 chr3:128968543 COPG 0.46 6.31 0.33 9.01e-10 Response to antipsychotic treatment; CRC cis rs10191773 0.584 rs72831633 chr2:112945932 T/G cg23609528 chr2:113191194 RGPD5;RGPD8 0.66 5.67 0.3 3.18e-8 Yeast infection; CRC cis rs35110281 0.659 rs73367822 chr21:45024252 C/T cg04455712 chr21:45112962 RRP1B 0.39 7.56 0.38 3.96e-13 Mean corpuscular volume; CRC cis rs9486719 0.843 rs1009597 chr6:96843540 A/T cg06623918 chr6:96969491 KIAA0776 0.79 8.57 0.43 4.23e-16 Migraine;Coronary artery disease; CRC cis rs17490626 0.533 rs5030925 chr10:71211150 A/C cg12610070 chr10:71211762 TSPAN15 -0.42 -7.66 -0.39 2.04e-13 Thrombosis; CRC cis rs10504229 0.953 rs66509078 chr8:58174734 G/C cg22535103 chr8:58192502 C8orf71 -0.82 -12.27 -0.56 9.63e-29 Developmental language disorder (linguistic errors); CRC trans rs3733585 0.638 rs13145554 chr4:9979589 C/T cg26043149 chr18:55253948 FECH 0.48 7.35 0.38 1.54e-12 Cleft plate (environmental tobacco smoke interaction); CRC cis rs2075371 1.000 rs1862047 chr7:133978078 G/C cg02659138 chr7:134003124 SLC35B4 0.36 6.19 0.32 1.77e-9 Mean platelet volume; CRC cis rs3820068 0.705 rs11587541 chr1:15899478 T/C cg27534772 chr1:16042836 PLEKHM2 0.45 7.63 0.39 2.52e-13 Systolic blood pressure; CRC cis rs4843747 0.671 rs8062855 chr16:88106941 T/C cg17633681 chr16:88106987 BANP 0.87 16.24 0.67 5.81e-44 Menopause (age at onset); CRC cis rs9488822 0.676 rs3798227 chr6:116324898 A/G cg15226275 chr6:116381976 FRK 0.3 8.5 0.42 6.55e-16 Cholesterol, total;LDL cholesterol; CRC cis rs10512697 0.803 rs13187916 chr5:3580499 A/G cg19473799 chr5:3511975 NA -0.7 -5.7 -0.3 2.71e-8 Immune response to smallpox vaccine (IL-6); CRC cis rs758324 0.898 rs7725041 chr5:131188503 C/A cg06307176 chr5:131281290 NA 0.42 6.14 0.32 2.32e-9 Alzheimer's disease in APOE e4- carriers; CRC cis rs2921073 0.605 rs2976933 chr8:8254875 A/G cg06636001 chr8:8085503 FLJ10661 0.64 9.15 0.45 6.22e-18 Parkinson's disease; CRC cis rs4604732 0.631 rs12091081 chr1:247623064 C/T cg12758973 chr1:247694275 LOC148824;OR2C3 0.47 6.44 0.33 4.32e-10 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CRC cis rs62432291 0.681 rs400477 chr6:159635943 A/C cg14500486 chr6:159655392 FNDC1 0.78 10.53 0.5 1.56e-22 Joint mobility (Beighton score); CRC cis rs11212617 0.967 rs228592 chr11:108123189 C/A cg01991180 chr11:108092276 ATM;NPAT 0.44 6.48 0.34 3.29e-10 Response to metformin in type 2 diabetes (glycemic); CRC cis rs10751667 0.643 rs10794343 chr11:925493 C/T cg01483505 chr11:975446 AP2A2 0.43 6.91 0.36 2.5e-11 Alzheimer's disease (late onset); CRC cis rs3091242 0.967 rs1053438 chr1:25687901 T/C cg20684491 chr1:25596433 NA -0.44 -7.84 -0.4 6.12e-14 Erythrocyte sedimentation rate; CRC cis rs7666738 0.830 rs7673880 chr4:99057262 A/G cg05340658 chr4:99064831 C4orf37 0.59 9.16 0.45 5.68e-18 Colonoscopy-negative controls vs population controls; CRC cis rs911555 0.755 rs10148970 chr14:103892000 G/A cg24130564 chr14:104152367 KLC1 -0.44 -6.02 -0.32 4.65e-9 Intelligence (multi-trait analysis); CRC cis rs6570726 0.905 rs396492 chr6:145816180 C/G cg05347473 chr6:146136440 FBXO30 0.37 5.91 0.31 8.46e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs78456975 1.000 rs10189336 chr2:1558015 G/A cg12573674 chr2:1569213 NA -0.77 -7.94 -0.4 3.17e-14 Placebo response in major depressive disorder (% change in symptom score); CRC cis rs2985684 0.948 rs11623263 chr14:50083295 A/G cg10008539 chr14:50087325 RPL36AL;MGAT2 -0.46 -6.15 -0.32 2.29e-9 Carotid intima media thickness; CRC cis rs17767392 0.958 rs4140797 chr14:72162978 T/C cg13720639 chr14:72061746 SIPA1L1 0.58 7.19 0.37 4.43e-12 Mitral valve prolapse; CRC cis rs1577917 0.839 rs9450333 chr6:86519755 A/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.46 -6.13 -0.32 2.56e-9 Response to antipsychotic treatment; CRC cis rs2072499 0.778 rs41265025 chr1:156163906 C/T cg24450063 chr1:156163899 SLC25A44 1.06 16.82 0.68 3.13e-46 Testicular germ cell tumor; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg05918682 chr3:127267038 NA 0.43 6.41 0.33 5.09e-10 Intelligence (multi-trait analysis); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg17322444 chr19:33572249 GPATCH1 0.46 6.49 0.34 3.15e-10 Response to antipsychotic treatment; CRC cis rs2346268 0.605 rs13310832 chr7:133646213 T/G cg03336402 chr7:133662267 EXOC4 -0.66 -10.33 -0.49 7.44e-22 Intelligence (multi-trait analysis); CRC cis rs12188164 0.965 rs41282625 chr5:475626 C/G cg15813090 chr5:442598 EXOC3;C5orf55 0.41 5.78 0.3 1.73e-8 Cystic fibrosis severity; CRC cis rs7259376 0.936 rs7256749 chr19:22592289 A/G cg02657401 chr19:22469223 NA 0.3 6.56 0.34 2.07e-10 Menopause (age at onset); CRC cis rs4731207 0.724 rs4146110 chr7:124561208 A/G cg23710748 chr7:124431027 NA -0.38 -6.02 -0.31 4.78e-9 Cutaneous malignant melanoma; CRC trans rs56114371 0.777 rs200482 chr6:27773904 G/A cg06606381 chr12:133084897 FBRSL1 -0.73 -6.45 -0.34 3.98e-10 Breast cancer; CRC cis rs13082711 0.911 rs7637211 chr3:27419868 C/T cg02860705 chr3:27208620 NA 0.63 8.88 0.44 4.57e-17 Systolic blood pressure;Diastolic blood pressure;Blood pressure; CRC trans rs11098499 0.913 rs10006304 chr4:120124305 A/G cg25214090 chr10:38739885 LOC399744 0.52 7.79 0.39 9.11e-14 Corneal astigmatism; CRC cis rs1506636 1.000 rs646753 chr7:123401237 G/T cg03229431 chr7:123269106 ASB15 0.73 11.64 0.54 1.85e-26 Plateletcrit;Platelet count; CRC cis rs17345786 0.906 rs72940399 chr3:101122575 A/T cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.58 6.85 0.35 3.63e-11 Colonoscopy-negative controls vs population controls; CRC cis rs6088590 0.561 rs764597 chr20:33161225 C/T cg08999081 chr20:33150536 PIGU 0.59 11.45 0.53 9.32e-26 Coronary artery disease; CRC cis rs7202877 0.706 rs247437 chr16:75431275 T/G cg03315344 chr16:75512273 CHST6 -0.5 -6.06 -0.32 3.83e-9 Type 2 diabetes;Type 1 diabetes; CRC cis rs951366 0.668 rs823154 chr1:205762406 C/T cg24503407 chr1:205819492 PM20D1 0.92 15.21 0.64 5.94e-40 Menarche (age at onset); CRC cis rs2565722 0.583 rs2465841 chr6:161295154 C/T cg03159191 chr6:161285451 NA -0.39 -6.0 -0.31 5.09e-9 Blood protein levels; CRC cis rs4927850 0.881 rs7624638 chr3:195748729 C/T cg01181863 chr3:195395398 SDHAP2 -0.57 -7.94 -0.4 3.29e-14 Pancreatic cancer; CRC cis rs1552244 0.832 rs66597916 chr3:10195407 T/C cg02579736 chr3:10068473 FANCD2;CIDECP 1.0 11.16 0.52 1.01e-24 Alzheimer's disease; CRC cis rs3026101 0.671 rs1806249 chr17:5311143 T/C cg25236894 chr17:5323110 RPAIN;NUP88 0.42 6.87 0.35 3.16e-11 Body mass index; CRC cis rs9926296 0.605 rs1800287 chr16:89858525 C/G cg04287289 chr16:89883240 FANCA 0.82 14.81 0.63 2.23e-38 Vitiligo; CRC cis rs11190604 1.000 rs79831012 chr10:102237059 T/C cg07080220 chr10:102295463 HIF1AN 0.47 5.68 0.3 2.92e-8 Palmitoleic acid (16:1n-7) levels; CRC cis rs7107174 0.901 rs11237459 chr11:78056273 A/C cg12700464 chr11:78128424 GAB2 -0.47 -5.76 -0.3 1.96e-8 Testicular germ cell tumor; CRC cis rs10155981 0.510 rs28439106 chr7:22592349 T/C cg05062323 chr7:22590069 NA -0.56 -5.85 -0.31 1.16e-8 Bilirubin levels; CRC cis rs651907 0.557 rs62284199 chr3:101478531 T/G cg12386194 chr3:101231763 SENP7 0.53 7.67 0.39 1.95e-13 Colorectal cancer; CRC cis rs12249377 0.519 rs35987367 chr10:92591992 C/T cg14313238 chr10:92632228 RPP30 0.48 6.63 0.34 1.36e-10 White matter microstructure (global fractional anisotropy); CRC trans rs2797160 1.000 rs1935773 chr6:125996475 A/G cg05039488 chr6:79577232 IRAK1BP1 -0.48 -7.0 -0.36 1.41e-11 Endometrial cancer; CRC trans rs7937682 0.889 rs1784786 chr11:111486043 A/G cg18187862 chr3:45730750 SACM1L -0.46 -6.72 -0.35 7.8e-11 Primary sclerosing cholangitis; CRC cis rs6534441 0.857 rs55698707 chr4:125456502 T/C cg21609808 chr4:125404261 NA 0.39 5.83 0.31 1.3e-8 Major depressive disorder; CRC cis rs2227564 0.533 rs3870402 chr10:75473787 A/C cg00564723 chr10:75632066 CAMK2G -0.32 -7.62 -0.39 2.8e-13 Crohn's disease;Inflammatory bowel disease; CRC cis rs3760982 1.000 rs11669175 chr19:44289824 A/G cg21496419 chr19:44306685 LYPD5 0.34 6.46 0.34 3.68e-10 Breast cancer (estrogen-receptor negative);Breast cancer; CRC cis rs7258465 1.000 rs10427083 chr19:18550276 C/A cg06953865 chr19:18549723 ISYNA1 -0.39 -5.76 -0.3 1.89e-8 Breast cancer; CRC cis rs12188164 0.900 rs72717425 chr5:438809 C/T cg17553881 chr5:443987 EXOC3;C5orf55 -0.32 -6.85 -0.35 3.58e-11 Cystic fibrosis severity; CRC cis rs7408868 1.000 rs10415431 chr19:15277027 G/A cg14696996 chr19:15285081 NOTCH3 0.96 9.0 0.44 1.82e-17 Pulse pressure; CRC cis rs477895 0.838 rs1058735 chr11:64000410 C/G cg23719950 chr11:63933701 MACROD1 -0.61 -7.46 -0.38 7.6e-13 Mean platelet volume; CRC cis rs34891900 0.507 rs2535679 chr22:18202850 A/G cg19898043 chr22:18121309 BCL2L13 0.53 8.44 0.42 9.98e-16 Sum neutrophil eosinophil counts; CRC cis rs9443645 0.901 rs6912683 chr6:79543492 C/A cg05283184 chr6:79620031 NA -0.58 -9.26 -0.45 2.66e-18 Intelligence (multi-trait analysis); CRC cis rs57221529 0.766 rs12521051 chr5:560440 A/G cg16447950 chr5:562315 NA 0.84 11.51 0.54 5.31e-26 Lung disease severity in cystic fibrosis; CRC cis rs9914988 0.943 rs7215000 chr17:27088436 C/T cg20469991 chr17:27169893 C17orf63 -0.6 -7.28 -0.37 2.5e-12 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs11098499 0.739 rs10031033 chr4:120151452 C/T cg24375607 chr4:120327624 NA 0.45 7.41 0.38 1.04e-12 Corneal astigmatism; CRC trans rs11148252 0.740 rs9536046 chr13:52955899 T/G cg18335740 chr13:41363409 SLC25A15 0.52 7.58 0.39 3.53e-13 Lewy body disease; CRC cis rs2933343 0.553 rs35076317 chr3:128715535 T/C cg11901034 chr3:128598214 ACAD9 -0.53 -7.12 -0.37 7e-12 IgG glycosylation; CRC cis rs2032447 0.507 rs199748 chr6:25909045 C/G cg15691649 chr6:25882328 NA -0.54 -7.07 -0.36 9.56e-12 Intelligence (multi-trait analysis); CRC cis rs4713118 0.662 rs9468274 chr6:28026077 G/T cg02683197 chr6:28174875 NA 0.75 9.8 0.48 4.46e-20 Parkinson's disease; CRC trans rs7395662 0.517 rs2021248 chr11:49013054 C/T cg00717180 chr2:96193071 NA -0.39 -6.43 -0.33 4.59e-10 HDL cholesterol; CRC cis rs6445525 0.967 rs7648741 chr3:65996570 T/C cg06109867 chr3:66002991 MAGI1 -0.39 -6.41 -0.33 5.07e-10 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg11296937 chr11:64084966 PRDX5;TRMT112 0.48 7.72 0.39 1.37e-13 Liver disease severity in Alagille syndrome; CRC cis rs921968 0.648 rs538483 chr2:219458656 T/C cg02176678 chr2:219576539 TTLL4 0.48 8.02 0.4 1.82e-14 Mean corpuscular hemoglobin concentration; CRC trans rs475616 0.917 rs866919 chr10:30513283 C/T cg16402443 chr7:2598526 IQCE 0.41 5.99 0.31 5.65e-9 Monocyte count; CRC cis rs863345 0.584 rs10908676 chr1:158506163 C/G cg12129480 chr1:158549410 OR10X1 -0.3 -6.31 -0.33 8.92e-10 Pneumococcal bacteremia; CRC cis rs7224737 1.000 rs2240010 chr17:40278081 T/A cg02228675 chr17:40259724 DHX58 -0.5 -6.99 -0.36 1.57e-11 Fibrinogen levels; CRC cis rs7914558 0.966 rs7096269 chr10:104736721 A/G cg04362960 chr10:104952993 NT5C2 0.62 9.43 0.46 7.79e-19 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs12477438 0.501 rs6753063 chr2:99801469 A/G cg14399236 chr2:99771627 LIPT1;TSGA10 0.81 14.32 0.62 1.66e-36 Chronic sinus infection; CRC trans rs3960554 0.800 rs112463197 chr7:75622912 C/T cg19862616 chr7:65841803 NCRNA00174 0.71 7.93 0.4 3.5e-14 Eotaxin levels; CRC cis rs910187 0.641 rs3818010 chr20:45816562 A/G cg27589058 chr20:45804311 EYA2 -0.39 -7.51 -0.38 5.63e-13 Migraine; CRC cis rs1799949 1.000 rs9646412 chr17:41425893 A/T cg23758822 chr17:41437982 NA 0.81 13.57 0.6 1.26e-33 Menopause (age at onset); CRC cis rs6502050 0.769 rs9898292 chr17:80100345 A/T cg02741985 chr17:80059408 CCDC57 0.43 7.15 0.37 5.66e-12 Life satisfaction; CRC cis rs9660180 0.783 rs1107910 chr1:1692321 C/T cg03396347 chr1:1875803 NA -0.51 -8.06 -0.41 1.4e-14 Body mass index; CRC cis rs5750830 0.649 rs5750814 chr22:39797987 T/C cg24399712 chr22:39784796 NA -0.53 -11.2 -0.53 7.21e-25 Intelligence (multi-trait analysis); CRC cis rs72615157 0.539 rs2261360 chr7:99692993 G/T cg22004693 chr7:99632812 ZKSCAN1 0.4 6.07 0.32 3.62e-9 Lung function (FEV1/FVC); CRC cis rs8077889 0.826 rs60085355 chr17:41847415 T/C cg25876840 chr17:41920477 NA 0.44 6.42 0.33 4.88e-10 Triglycerides; CRC cis rs2976388 0.578 rs13263987 chr8:143827387 A/C cg04969067 chr8:143858791 LYNX1 -0.41 -6.19 -0.32 1.81e-9 Urinary tract infection frequency; CRC cis rs950169 0.541 rs10795 chr15:85177297 G/A cg17507749 chr15:85114479 UBE2QP1 0.65 9.29 0.46 2.15e-18 Schizophrenia; CRC cis rs78545713 0.649 rs11754368 chr6:26221173 G/A cg01420254 chr6:26195488 NA 0.66 5.87 0.31 1.04e-8 Iron status biomarkers (total iron binding capacity); CRC trans rs3733585 0.673 rs4580649 chr4:9948461 G/A cg26043149 chr18:55253948 FECH -0.45 -6.79 -0.35 5.1e-11 Cleft plate (environmental tobacco smoke interaction); CRC trans rs1945213 0.694 rs7131381 chr11:55858158 T/G cg15704280 chr7:45808275 SEPT13 0.56 6.27 0.33 1.15e-9 Acute lymphoblastic leukemia (childhood); CRC cis rs7249142 0.526 rs7256811 chr19:19283551 A/G cg12558012 chr19:19281197 LOC729991-MEF2B;MEF2B 0.59 9.36 0.46 1.27e-18 IgG glycosylation; CRC trans rs7267979 1.000 rs2257991 chr20:25270339 C/T cg17903999 chr18:56338584 MALT1 0.41 6.77 0.35 5.9e-11 Liver enzyme levels (alkaline phosphatase); CRC cis rs6500602 0.727 rs12443748 chr16:4541831 C/T cg08645402 chr16:4508243 NA 0.6 10.52 0.5 1.63e-22 Schizophrenia; CRC cis rs554111 0.891 rs671905 chr1:21047092 A/T cg00373020 chr1:21041521 KIF17 0.39 6.04 0.32 4.19e-9 Facial morphology (factor 17, height of vermillion upper lip); CRC cis rs7829975 0.572 rs28446104 chr8:8795901 C/G cg06636001 chr8:8085503 FLJ10661 -0.51 -7.39 -0.38 1.21e-12 Mood instability; CRC cis rs644799 0.562 rs1254989 chr11:95508121 A/G cg25478527 chr11:95522999 CEP57;FAM76B 0.39 5.64 0.3 3.61e-8 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs2688482 0.512 rs3103953 chr3:195520597 G/A cg13752114 chr3:195489708 MUC4 -0.77 -8.71 -0.43 1.53e-16 Lung disease severity in cystic fibrosis; CRC cis rs1109861 0.538 rs10905907 chr10:11219411 T/A cg24910943 chr10:11206320 CUGBP2 0.33 8.76 0.43 1.07e-16 Urinary albumin-to-creatinine ratio; CRC cis rs59104589 0.617 rs3755395 chr2:242294116 A/G cg19488206 chr2:242435732 STK25 0.45 6.05 0.32 3.85e-9 Fibrinogen levels; CRC cis rs9399137 0.507 rs10484496 chr6:135299682 T/C cg22676075 chr6:135203613 NA 0.59 8.98 0.44 2.14e-17 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; CRC cis rs6120849 0.754 rs6088678 chr20:33607551 A/G cg08999081 chr20:33150536 PIGU -0.46 -6.03 -0.32 4.51e-9 Protein C levels; CRC cis rs2075371 0.796 rs7780583 chr7:133960716 C/G cg20476274 chr7:133979776 SLC35B4 0.72 11.95 0.55 1.38e-27 Mean platelet volume; CRC cis rs1448094 0.842 rs12318815 chr12:86452281 T/C cg02569458 chr12:86230093 RASSF9 -0.41 -6.94 -0.36 2.05e-11 Major depressive disorder; CRC cis rs2479724 0.905 rs2149274 chr6:41839092 T/C cg17623882 chr6:41773611 USP49 -0.58 -9.96 -0.48 1.37e-20 Menarche (age at onset); CRC cis rs9368481 0.554 rs2754603 chr6:26965139 T/C cg18867708 chr6:26865862 GUSBL1 -0.41 -5.72 -0.3 2.34e-8 Autism spectrum disorder or schizophrenia; CRC cis rs9733 0.543 rs72702558 chr1:150683251 G/A cg15448220 chr1:150897856 SETDB1 0.45 6.41 0.33 5.09e-10 Tonsillectomy; CRC cis rs9467773 0.596 rs2494693 chr6:26619226 T/C cg09904177 chr6:26538194 HMGN4 0.72 11.21 0.53 6.63e-25 Intelligence (multi-trait analysis); CRC cis rs1552244 0.688 rs7645137 chr3:10020549 A/AT cg13047869 chr3:10149882 C3orf24 0.52 7.04 0.36 1.15e-11 Alzheimer's disease; CRC cis rs73195822 0.614 rs17793540 chr12:111215575 C/T cg12870014 chr12:110450643 ANKRD13A 0.66 7.22 0.37 3.66e-12 Itch intensity from mosquito bite; CRC cis rs2153535 0.580 rs9328484 chr6:8524843 A/T cg21535247 chr6:8435926 SLC35B3 0.48 7.39 0.38 1.21e-12 Motion sickness; CRC cis rs722599 0.847 rs2058919 chr14:75310812 C/G cg03030879 chr14:75389066 RPS6KL1 0.38 5.79 0.3 1.67e-8 IgG glycosylation; CRC cis rs13392177 0.684 rs6720449 chr2:219080978 G/A cg04731861 chr2:219085781 ARPC2 0.34 6.78 0.35 5.57e-11 Pyoderma gangrenosum in inflammatory bowel disease; CRC cis rs4547160 0.606 rs12828712 chr12:63475233 G/C cg26727693 chr12:63544175 AVPR1A -0.41 -7.44 -0.38 8.64e-13 Morning vs. evening chronotype; CRC cis rs644799 0.930 rs2186782 chr11:95649543 G/A cg03916912 chr11:95522834 CEP57;FAM76B 0.95 17.19 0.69 1.02e-47 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs2836974 0.605 rs2836971 chr21:40652040 A/C cg22974920 chr21:40686053 BRWD1 -0.43 -5.94 -0.31 7.38e-9 Cognitive function; CRC cis rs995000 0.965 rs10789116 chr1:63042738 A/G cg19896129 chr1:63156450 NA 0.39 5.72 0.3 2.39e-8 Triglyceride levels; CRC cis rs9462027 0.628 rs2814967 chr6:34712838 C/T cg07306190 chr6:34760872 UHRF1BP1 -0.35 -6.25 -0.33 1.28e-9 Systemic lupus erythematosus; CRC cis rs798554 0.759 rs798495 chr7:2797267 T/C cg14895029 chr7:2775587 GNA12 -0.48 -7.03 -0.36 1.21e-11 Height; CRC trans rs3733585 0.699 rs7683283 chr4:9969974 T/C cg26043149 chr18:55253948 FECH -0.49 -7.59 -0.39 3.28e-13 Cleft plate (environmental tobacco smoke interaction); CRC cis rs7959452 0.558 rs1478464 chr12:69779789 G/C cg22834771 chr12:69754056 YEATS4 -0.5 -7.38 -0.38 1.27e-12 Blood protein levels; CRC cis rs68149176 0.772 rs997761 chr16:87879522 A/C cg03553613 chr16:87879502 SLC7A5 0.56 7.55 0.38 4.19e-13 Mean corpuscular volume;Mean corpuscular hemoglobin; CRC cis rs12134245 0.747 rs17501512 chr1:92012481 C/G cg02896835 chr1:92012615 NA 0.63 11.36 0.53 1.92e-25 Breast cancer; CRC cis rs13082711 0.911 rs34307140 chr3:27467875 A/C cg02860705 chr3:27208620 NA 0.59 8.58 0.43 3.87e-16 Systolic blood pressure;Diastolic blood pressure;Blood pressure; CRC cis rs8114671 0.562 rs6087642 chr20:33468306 T/C cg07148914 chr20:33460835 GGT7 0.37 6.35 0.33 7.08e-10 Height; CRC cis rs10504229 0.683 rs7820302 chr8:58142502 C/T cg21724239 chr8:58056113 NA 0.49 7.08 0.36 8.56e-12 Developmental language disorder (linguistic errors); CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg07355551 chr20:2489285 ZNF343 -0.51 -6.25 -0.33 1.31e-9 Diisocyanate-induced asthma; CRC cis rs7772486 0.875 rs2748498 chr6:146319166 C/G cg13319975 chr6:146136371 FBXO30 -0.38 -5.63 -0.3 3.81e-8 Lobe attachment (rater-scored or self-reported); CRC cis rs7927592 0.913 rs7104345 chr11:68316772 G/A cg01657329 chr11:68192670 LRP5 -0.46 -6.65 -0.34 1.22e-10 Total body bone mineral density; CRC cis rs13315871 1.000 rs71311870 chr3:58399283 T/C cg20936604 chr3:58311152 NA -0.75 -7.14 -0.37 5.96e-12 Cholesterol, total; CRC cis rs4713118 0.662 rs469228 chr6:27970704 A/G cg15845792 chr6:28175446 NA 0.8 11.85 0.55 3.12e-27 Parkinson's disease; CRC cis rs10751667 0.600 rs10751665 chr11:941300 G/A ch.11.42038R chr11:967971 AP2A2 0.6 10.27 0.49 1.24e-21 Alzheimer's disease (late onset); CRC cis rs4555082 0.645 rs2816605 chr14:105715515 C/T cg18132624 chr14:105716052 BTBD6;BRF1 -0.52 -8.25 -0.41 3.79e-15 Mean platelet volume;Platelet distribution width; CRC cis rs7618915 0.570 rs11130319 chr3:52755592 A/T cg05573699 chr3:52720067 GNL3;PBRM1 -0.48 -6.86 -0.35 3.5e-11 Bipolar disorder; CRC cis rs875971 0.798 rs6460304 chr7:65964728 G/A cg00343986 chr7:65444356 GUSB 0.43 6.05 0.32 3.87e-9 Aortic root size; CRC cis rs2857891 0.650 rs2638087 chr11:6990516 C/T cg04053776 chr11:6947353 ZNF215 0.42 6.37 0.33 6.33e-10 Response to cytadine analogues (cytosine arabinoside); CRC cis rs11785400 0.793 rs10956992 chr8:143736235 A/C cg24634471 chr8:143751801 JRK 0.51 7.1 0.36 7.55e-12 Schizophrenia; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg01766191 chr11:57103423 SSRP1 0.4 6.4 0.33 5.34e-10 Liver disease severity in Alagille syndrome; CRC trans rs10802346 0.515 rs1113270 chr1:246423217 A/G cg22732515 chr19:44031385 ETHE1 0.71 11.15 0.52 1.06e-24 Fractional exhaled nitric oxide (childhood); CRC cis rs10493773 0.609 rs11161660 chr1:86184066 C/T cg23216685 chr1:86174607 ZNHIT6 -0.27 -6.38 -0.33 5.95e-10 Urate levels in overweight individuals; CRC cis rs79387448 0.626 rs80256362 chr2:103025501 A/G cg00507830 chr2:103233733 NA 0.58 6.05 0.32 3.86e-9 Gut microbiota (bacterial taxa); CRC cis rs853679 0.517 rs9283884 chr6:28135660 C/G cg12273811 chr6:28175739 NA -0.68 -8.28 -0.42 3.04e-15 Depression; CRC cis rs62064224 0.554 rs9889352 chr17:30775761 T/C cg12855166 chr17:30846586 MYO1D -0.38 -6.15 -0.32 2.22e-9 Schizophrenia; CRC cis rs1801251 1.000 rs6746294 chr2:233583050 C/G cg25237894 chr2:233734115 C2orf82 -0.48 -7.39 -0.38 1.22e-12 Coronary artery disease; CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg05787931 chr3:52232012 ALAS1 0.4 6.21 0.32 1.6e-9 Obesity-related traits; CRC cis rs2257205 0.667 rs28363312 chr17:56788293 C/A cg25885038 chr17:56607967 SEPT4 -0.52 -5.71 -0.3 2.5e-8 Pancreatic cancer; CRC cis rs7178572 1.000 rs952471 chr15:77776498 C/G cg22256960 chr15:77711686 NA -0.7 -10.77 -0.51 2.3e-23 Type 2 diabetes; CRC cis rs972578 0.776 rs2267464 chr22:43298646 T/G cg01576275 chr22:43409880 NA -0.42 -6.56 -0.34 2.1e-10 Mean platelet volume; CRC cis rs9549328 0.542 rs36172983 chr13:113616582 T/C cg25790453 chr13:113633590 MCF2L 0.43 7.55 0.38 4.25e-13 Systolic blood pressure; CRC cis rs79387448 0.745 rs7582378 chr2:103162263 C/A cg00507830 chr2:103233733 NA 0.51 5.61 0.3 4.25e-8 Gut microbiota (bacterial taxa); CRC cis rs10504229 0.906 rs66480865 chr8:58187100 C/T cg01721255 chr8:58191610 C8orf71 0.49 6.17 0.32 2e-9 Developmental language disorder (linguistic errors); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg01490821 chr2:170684022 UBR3 0.42 6.01 0.31 4.86e-9 Intelligence (multi-trait analysis); CRC cis rs9322193 0.962 rs9688940 chr6:150110113 G/A cg13206674 chr6:150067644 NUP43 0.57 8.14 0.41 8.29e-15 Lung cancer; CRC cis rs13191362 0.507 rs2023015 chr6:163060528 A/T cg21926612 chr6:163149169 PACRG;PARK2 -0.6 -9.64 -0.47 1.61e-19 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs1552244 0.816 rs17050701 chr3:10041554 A/G cg02579736 chr3:10068473 FANCD2;CIDECP 0.93 12.04 0.55 6.69e-28 Alzheimer's disease; CRC trans rs9858542 1.000 rs9822268 chr3:49719729 G/A cg21665057 chr3:196295764 WDR53;FBXO45 -0.69 -9.02 -0.45 1.59e-17 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC trans rs656319 0.605 rs17747335 chr8:10003186 A/T cg06636001 chr8:8085503 FLJ10661 -0.47 -7.05 -0.36 1.03e-11 Myopia (pathological); CRC cis rs9399135 0.967 rs12527683 chr6:135324534 C/T cg22676075 chr6:135203613 NA 0.42 6.47 0.34 3.54e-10 Red blood cell count; CRC cis rs2276314 1.000 rs56050783 chr18:33553791 A/G cg05985134 chr18:33552581 C18orf21 0.47 6.51 0.34 2.78e-10 Endometriosis;Drug-induced torsades de pointes; CRC cis rs2836974 0.965 rs8134733 chr21:40683459 C/T cg11644478 chr21:40555479 PSMG1 0.78 11.46 0.53 8.52e-26 Cognitive function; CRC cis rs936229 0.656 rs12898397 chr15:75130093 T/C cg09165964 chr15:75287851 SCAMP5 0.49 7.74 0.39 1.2e-13 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); CRC cis rs9462027 0.517 rs2744973 chr6:34580221 C/T cg07306190 chr6:34760872 UHRF1BP1 -0.34 -5.82 -0.31 1.43e-8 Systemic lupus erythematosus; CRC cis rs9903692 0.954 rs6847 chr17:46147807 A/T cg21215337 chr17:46176117 CBX1 -0.41 -7.47 -0.38 7.48e-13 Pulse pressure; CRC cis rs73206853 0.563 rs55885633 chr12:111189251 C/T cg12870014 chr12:110450643 ANKRD13A 0.56 5.95 0.31 7.05e-9 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC trans rs10028773 0.506 rs12374346 chr4:120281705 G/A cg25214090 chr10:38739885 LOC399744 0.61 9.66 0.47 1.39e-19 Educational attainment; CRC cis rs59918340 0.764 rs9324542 chr8:142227854 A/T cg17298326 chr8:142245477 NA 0.36 5.62 0.3 4e-8 Immature fraction of reticulocytes; CRC cis rs28386778 0.863 rs3826341 chr17:61819222 C/A cg22520471 chr17:61851767 DDX42;CCDC47 0.73 11.25 0.53 4.55e-25 Prudent dietary pattern; CRC cis rs2239547 0.522 rs2564947 chr3:53046216 C/T cg15147215 chr3:52552868 STAB1 0.39 5.89 0.31 9.57e-9 Schizophrenia; CRC cis rs763014 0.966 rs12935215 chr16:670605 T/C cg09263875 chr16:632152 PIGQ 0.79 12.79 0.58 1.09e-30 Height; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg26559770 chr13:45563685 NUFIP1;KIAA1704 0.46 6.32 0.33 8.7e-10 Anxiety disorder; CRC cis rs4243830 0.737 rs11122083 chr1:6593532 A/G cg22792644 chr1:6614718 TAS1R1;NOL9 -0.79 -8.0 -0.4 2.15e-14 Body mass index; CRC cis rs7662987 0.517 rs2924580 chr4:100032168 C/G cg13256891 chr4:100009986 ADH5 0.63 8.57 0.43 3.97e-16 Smoking initiation; CRC cis rs68170813 0.559 rs76933738 chr7:106814574 T/C cg02696742 chr7:106810147 HBP1 -0.64 -7.22 -0.37 3.69e-12 Coronary artery disease; CRC cis rs2976388 0.566 rs13250661 chr8:143804134 C/T cg04969067 chr8:143858791 LYNX1 -0.42 -6.63 -0.34 1.42e-10 Urinary tract infection frequency; CRC cis rs11212617 1.000 rs186593 chr11:108262439 G/A cg14761454 chr11:108092087 ATM;NPAT 0.44 6.64 0.34 1.3e-10 Response to metformin in type 2 diabetes (glycemic); CRC cis rs9487051 0.872 rs9487033 chr6:109605388 C/G cg01475377 chr6:109611718 NA 0.5 9.41 0.46 8.79e-19 Reticulocyte fraction of red cells; CRC cis rs6089584 0.706 rs6089625 chr20:60620622 T/C cg23463467 chr20:60627584 TAF4 0.33 5.74 0.3 2.1e-8 Body mass index; CRC cis rs2811415 0.627 rs9833276 chr3:127797793 T/C cg13719885 chr3:127795394 NA -0.4 -6.02 -0.32 4.57e-9 Lung function (FEV1/FVC); CRC cis rs7615952 0.688 rs12485622 chr3:125710739 T/C cg02772935 chr3:125709198 NA -0.49 -5.89 -0.31 9.34e-9 Blood pressure (smoking interaction); CRC cis rs896854 0.812 rs12546365 chr8:95911477 T/C cg16049864 chr8:95962084 TP53INP1 -0.63 -11.07 -0.52 2.04e-24 Type 2 diabetes; CRC trans rs57221529 0.766 rs12519763 chr5:559145 C/T cg25482853 chr8:67687455 SGK3 1.25 15.72 0.65 6.58e-42 Lung disease severity in cystic fibrosis; CRC cis rs7552404 0.961 rs448710 chr1:76116554 T/C cg22875332 chr1:76189707 ACADM -0.68 -9.25 -0.45 3.02e-18 Blood metabolite levels;Acylcarnitine levels; CRC cis rs1046896 0.731 rs9906115 chr17:80791469 G/A cg19500275 chr17:80737654 TBCD 0.51 6.82 0.35 4.37e-11 Glycated hemoglobin levels; CRC cis rs9325144 0.541 rs7303395 chr12:38664124 C/T cg26384229 chr12:38710491 ALG10B -0.55 -8.21 -0.41 5.22e-15 Morning vs. evening chronotype; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg24883709 chr7:2595326 C7orf27 0.4 6.25 0.33 1.24e-9 Intelligence (multi-trait analysis); CRC cis rs9910055 0.529 rs228765 chr17:42186422 C/T cg19774624 chr17:42201019 HDAC5 0.43 5.75 0.3 2.04e-8 Total body bone mineral density; CRC cis rs4713118 0.869 rs4713121 chr6:27722064 T/C cg03623178 chr6:28175578 NA 0.73 9.11 0.45 8.42e-18 Parkinson's disease; CRC cis rs807669 0.934 rs762523 chr22:19180589 A/G cg02655711 chr22:19163373 SLC25A1 0.98 20.12 0.74 2.92e-59 Metabolite levels; CRC cis rs10924970 0.649 rs12753233 chr1:235487094 C/T cg09010748 chr1:235293032 TOMM20 -0.4 -5.7 -0.3 2.69e-8 Asthma; CRC cis rs796364 0.760 rs56285751 chr2:200919836 C/T cg25936922 chr2:200820526 C2orf60;C2orf47 -0.7 -6.62 -0.34 1.47e-10 Schizophrenia; CRC cis rs798554 0.757 rs1713919 chr7:2864706 C/A cg17321639 chr7:2759063 NA -0.53 -7.13 -0.37 6.31e-12 Height; CRC cis rs796364 1.000 rs281771 chr2:200812202 A/C cg12253985 chr2:200820533 C2orf60;C2orf47 -0.58 -6.56 -0.34 2.08e-10 Schizophrenia; CRC cis rs3820068 0.603 rs7536654 chr1:15989141 C/G cg13390004 chr1:15929781 NA 0.44 6.3 0.33 9.39e-10 Systolic blood pressure; CRC cis rs3093024 0.839 rs968334 chr6:167526096 T/C cg07741184 chr6:167504864 NA -0.33 -5.86 -0.31 1.14e-8 Rheumatoid arthritis; CRC cis rs17666538 0.792 rs7820788 chr8:601846 C/T cg02524346 chr8:600233 NA 0.99 9.51 0.46 4.22e-19 IgG glycosylation; CRC cis rs1552244 0.882 rs34779351 chr3:10021801 A/G cg00166722 chr3:10149974 C3orf24 0.61 7.92 0.4 3.81e-14 Alzheimer's disease; CRC cis rs1005277 0.579 rs1740747 chr10:38520465 G/A cg25427524 chr10:38739819 LOC399744 -0.79 -14.49 -0.62 3.78e-37 Extrinsic epigenetic age acceleration; CRC cis rs447 1.000 rs447 chr7:83772415 A/G cg22846510 chr7:83753280 SEMA3A -0.6 -7.62 -0.39 2.71e-13 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs3857067 0.806 rs17302300 chr4:95109177 T/C cg11021082 chr4:95130006 SMARCAD1 -0.5 -7.81 -0.4 7.99e-14 QT interval; CRC cis rs10870270 0.956 rs10870281 chr10:133762642 G/A cg08754478 chr10:133766260 PPP2R2D -0.66 -9.33 -0.46 1.67e-18 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; CRC cis rs7811142 1.000 rs6975729 chr7:100028187 C/T cg00814883 chr7:100076585 TSC22D4 -0.75 -9.53 -0.47 3.63e-19 Platelet count; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg18876494 chr12:69004196 RAP1B 0.41 6.6 0.34 1.7e-10 Liver disease severity in Alagille syndrome; CRC cis rs2949837 0.528 rs10260816 chr7:46010100 C/G cg23193639 chr7:45961078 IGFBP3 -0.45 -7.31 -0.37 1.98e-12 Sitting height ratio; CRC cis rs727563 0.638 rs4820443 chr22:42193913 A/G cg06634786 chr22:41940651 POLR3H -0.66 -7.57 -0.39 3.88e-13 Crohn's disease;Inflammatory bowel disease; CRC cis rs910316 1.000 rs175442 chr14:75603564 T/C cg08847533 chr14:75593920 NEK9 -0.89 -16.41 -0.67 1.22e-44 Height; CRC cis rs10089 0.953 rs4835940 chr5:127406596 A/G cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.73 10.43 0.5 3.2800000000000002e-22 Ileal carcinoids; CRC cis rs9322817 0.691 rs56075147 chr6:105337494 T/A cg02098413 chr6:105308735 HACE1 0.46 9.22 0.45 3.78e-18 Thyroid stimulating hormone; CRC cis rs1707322 1.000 rs785504 chr1:46595696 C/T cg03146154 chr1:46216737 IPP -0.52 -7.15 -0.37 5.72e-12 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs1008375 0.900 rs4698625 chr4:17599500 G/T cg16339924 chr4:17578868 LAP3 0.63 8.08 0.41 1.26e-14 Parasitemia in Tripanosoma cruzi seropositivity; CRC trans rs1488564 1.000 rs1488564 chr3:173453868 A/G cg09596707 chr12:66889730 GRIP1 -0.35 -5.99 -0.31 5.49e-9 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs7503807 0.515 rs12453034 chr17:78682756 G/A cg00549398 chr17:78725201 RPTOR 0.43 5.77 0.3 1.86e-8 Obesity; CRC cis rs1873147 0.569 rs12593573 chr15:63309919 G/A cg12160578 chr15:63334699 TPM1 0.63 7.53 0.38 5.02e-13 Orofacial clefts; CRC cis rs727563 0.638 rs5996058 chr22:42141452 A/G cg06634786 chr22:41940651 POLR3H 0.68 7.74 0.39 1.2e-13 Crohn's disease;Inflammatory bowel disease; CRC trans rs11764590 0.694 rs55860148 chr7:2105594 G/A cg11693508 chr17:37793320 STARD3 0.61 7.79 0.39 8.82e-14 Neuroticism; CRC cis rs17095355 1.000 rs17095350 chr10:111701708 T/C cg00817464 chr10:111662876 XPNPEP1 -0.6 -8.02 -0.4 1.84e-14 Biliary atresia; CRC cis rs7959452 0.590 rs28778648 chr12:69771911 C/A cg20891283 chr12:69753455 YEATS4 0.9 17.01 0.68 5.36e-47 Blood protein levels; CRC cis rs4478137 0.839 rs3967763 chr4:164239273 G/C cg06758707 chr4:164254230 NPY1R 0.39 6.01 0.31 4.89e-9 Subjective well-being (multi-trait analysis);Subjective well-being; CRC cis rs6502050 0.835 rs34673303 chr17:80085144 G/C cg19223190 chr17:80058835 NA -0.39 -6.24 -0.33 1.31e-9 Life satisfaction; CRC trans rs1908814 0.516 rs4841641 chr8:11798227 G/A cg06636001 chr8:8085503 FLJ10661 0.45 6.69 0.35 9.61e-11 Neuroticism; CRC cis rs737008 0.922 rs28567501 chr16:11378928 C/A cg00044050 chr16:11439710 C16orf75 -0.44 -5.98 -0.31 5.69e-9 Obesity-related traits; CRC cis rs853679 0.517 rs9368551 chr6:28061792 A/G cg15845792 chr6:28175446 NA 0.98 13.03 0.58 1.45e-31 Depression; CRC cis rs12291225 0.546 rs12795545 chr11:14355564 G/A cg05501817 chr11:14380813 RRAS2 -0.46 -6.37 -0.33 6.21e-10 Sense of smell; CRC cis rs7618915 0.570 rs13068293 chr3:52672167 C/A cg07507251 chr3:52567010 NT5DC2 0.42 6.04 0.32 4.11e-9 Bipolar disorder; CRC cis rs10751667 0.643 rs10751669 chr11:942344 C/G cg23136738 chr11:925521 AP2A2 0.4 6.67 0.34 1.11e-10 Alzheimer's disease (late onset); CRC cis rs7659604 0.967 rs28529384 chr4:122664215 T/C cg20573242 chr4:122745356 CCNA2 0.42 6.25 0.33 1.27e-9 Type 2 diabetes; CRC cis rs4665809 0.590 rs1560865 chr2:26452197 C/A cg04944784 chr2:26401820 FAM59B -0.87 -11.85 -0.55 3.24e-27 Gut microbiome composition (summer); CRC cis rs6662572 0.671 rs11211220 chr1:46365501 G/A cg03123370 chr1:45965343 CCDC163P;MMACHC -0.45 -5.72 -0.3 2.4e-8 Blood protein levels; CRC cis rs10504229 0.638 rs6981055 chr8:58113941 T/C cg24829409 chr8:58192753 C8orf71 -0.54 -7.88 -0.4 4.9e-14 Developmental language disorder (linguistic errors); CRC trans rs116095464 0.558 rs7715108 chr5:264661 A/G cg00938859 chr5:1591904 SDHAP3 0.73 7.89 0.4 4.53e-14 Breast cancer; CRC cis rs9682041 0.696 rs11917147 chr3:170088448 C/T cg11886554 chr3:170076028 SKIL 0.69 8.18 0.41 6.39e-15 Glomerular filtration rate in non diabetics (creatinine);Glomerular filtration rate (creatinine); CRC cis rs9648716 1.000 rs6965532 chr7:140597516 G/C cg10747023 chr7:140774559 NA 0.45 5.9 0.31 9.21e-9 Type 2 diabetes; CRC cis rs734999 0.566 rs6424092 chr1:2532899 C/A cg18854424 chr1:2615690 NA -0.42 -8.05 -0.41 1.49e-14 Ulcerative colitis; CRC cis rs9814567 1.000 rs1534026 chr3:134284767 A/G cg06541857 chr3:134203789 ANAPC13;CEP63 -0.4 -5.99 -0.31 5.53e-9 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs9976767 0.932 rs11910048 chr21:43822576 C/T cg23042151 chr21:43824109 UBASH3A -0.37 -6.5 -0.34 2.97e-10 Type 1 diabetes; CRC cis rs11098499 0.954 rs11722872 chr4:120233030 G/C cg09307838 chr4:120376055 NA 0.68 10.22 0.49 1.71e-21 Corneal astigmatism; CRC cis rs2882667 0.690 rs10044401 chr5:138237557 A/G cg09476006 chr5:138032270 NA 0.55 9.14 0.45 6.76e-18 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs62402013 1 rs62402013 chr6:26915000 A/G cg12292205 chr6:26970375 C6orf41 0.67 10.9 0.52 7.94e-24 Schizophrenia; CRC cis rs11212617 1.000 rs10431060 chr11:108288228 A/C cg12106634 chr11:108092400 ATM;NPAT 0.41 6.08 0.32 3.34e-9 Response to metformin in type 2 diabetes (glycemic); CRC cis rs7835763 0.518 rs2445906 chr8:119106346 C/T cg11592677 chr8:119110466 EXT1 -0.39 -6.45 -0.33 4.08e-10 Autism spectrum disorder; CRC cis rs1448094 0.512 rs7134732 chr12:86241908 T/C cg00310523 chr12:86230176 RASSF9 0.33 5.62 0.3 3.97e-8 Major depressive disorder; CRC cis rs6502050 0.835 rs3088177 chr17:80111724 A/G cg09264619 chr17:80180166 NA -0.35 -5.83 -0.31 1.35e-8 Life satisfaction; CRC cis rs8077889 0.672 rs1230400 chr17:41845451 G/A cg25876840 chr17:41920477 NA -0.41 -6.58 -0.34 1.87e-10 Triglycerides; CRC cis rs7647973 1.000 rs6783003 chr3:49524778 G/C cg07636037 chr3:49044803 WDR6 -0.64 -7.38 -0.38 1.26e-12 Menarche (age at onset); CRC cis rs6570726 0.791 rs9403730 chr6:145907233 C/T cg05347473 chr6:146136440 FBXO30 0.38 5.8 0.3 1.54e-8 Lobe attachment (rater-scored or self-reported); CRC cis rs875971 0.862 rs2088653 chr7:65808608 G/A cg11764359 chr7:65958608 NA -0.59 -8.76 -0.43 1.05e-16 Aortic root size; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg06223186 chr7:1544111 INTS1 0.4 6.59 0.34 1.75e-10 Liver disease severity in Alagille syndrome; CRC cis rs115344852 0.575 rs1015811 chr6:28448086 A/G cg03623178 chr6:28175578 NA 0.48 5.8 0.3 1.57e-8 Epithelial ovarian cancer; CRC cis rs4819052 0.851 rs2236444 chr21:46678226 T/C cg11663144 chr21:46675770 NA -0.83 -13.73 -0.6 3.03e-34 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs7619833 0.592 rs4973756 chr3:27248190 C/T cg02860705 chr3:27208620 NA 0.38 5.94 0.31 7.08e-9 Breast cancer; CRC cis rs9649213 0.555 rs67132564 chr7:98014900 T/A cg00277769 chr7:97922759 BAIAP2L1 -0.58 -10.02 -0.48 8.56e-21 Prostate cancer (SNP x SNP interaction); CRC cis rs13118159 0.872 rs4974605 chr4:1346389 C/G cg16405210 chr4:1374714 KIAA1530 -0.4 -5.71 -0.3 2.49e-8 Longevity; CRC cis rs9303401 0.555 rs8073699 chr17:57236317 G/A cg02118635 chr17:56770003 RAD51C;TEX14 0.46 6.95 0.36 1.95e-11 Cognitive test performance; CRC cis rs4665809 0.549 rs7577896 chr2:26524493 C/T cg08067268 chr2:26466485 HADHB;HADHA 0.56 6.43 0.33 4.54e-10 Gut microbiome composition (summer); CRC cis rs6918586 0.658 rs198826 chr6:26121153 A/G cg18357526 chr6:26021779 HIST1H4A 0.5 7.34 0.38 1.64e-12 Schizophrenia; CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg09060823 chr12:56862504 SPRYD4 -0.51 -6.17 -0.32 1.98e-9 Diisocyanate-induced asthma; CRC cis rs10504229 0.683 rs55637580 chr8:58135419 C/T cg21724239 chr8:58056113 NA 0.49 6.81 0.35 4.75e-11 Developmental language disorder (linguistic errors); CRC cis rs1023500 0.505 rs134885 chr22:42673811 C/G cg04733989 chr22:42467013 NAGA 0.44 6.42 0.33 4.67e-10 Schizophrenia; CRC cis rs780094 0.500 rs12473139 chr2:27765587 T/C cg27432699 chr2:27873401 GPN1 0.47 6.08 0.32 3.26e-9 Calcium levels;Fasting blood insulin;Metabolic traits;Triglyceride levels;Fasting plasma glucose;Urate levels in overweight individuals;Urate levels in obese individuals;Uric acid levels;Height;Age-related diseases, mortality and associated endophenotypes;Renal underexcretion gout;Fasting blood glucose (BMI interaction);Urate levels;Gondoic acid (20:1n-9) levels;Fasting blood insulin (BMI interaction);Triglycerides;Plasma omega-3 polyunsaturated fatty acid levels (docosapentaenoic acid);Type 2 diabetes;Nonalcoholic fatty liver disease;Hypertriglyceridemia;C-reactive protein;Age-related disease endophenotypes;LDL cholesterol;Metabolic syndrome;Crohn's disease;Alcohol consumption (drinks per week);Homeostasis model assessment of insulin resistance;Alcohol consumption;Red blood cell count;Fasting blood glucose; CRC cis rs4713118 0.869 rs6930992 chr6:27712120 A/C cg03623178 chr6:28175578 NA 0.66 9.34 0.46 1.46e-18 Parkinson's disease; CRC cis rs9491140 0.539 rs11154232 chr6:124691494 G/A cg22366943 chr6:124882293 NKAIN2 0.57 7.88 0.4 4.9e-14 Neuroticism; CRC cis rs875971 0.862 rs6944374 chr7:65686929 C/G cg11764359 chr7:65958608 NA -0.57 -8.37 -0.42 1.73e-15 Aortic root size; CRC cis rs3862030 0.839 rs7078679 chr10:104284017 C/G cg11453585 chr10:104263688 ACTR1A;SUFU -0.77 -13.4 -0.59 5.88e-33 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for body mass index; CRC cis rs9488822 0.676 rs12190737 chr6:116328128 C/A cg18764771 chr6:116381957 FRK 0.25 7.0 0.36 1.42e-11 Cholesterol, total;LDL cholesterol; CRC trans rs1728785 0.818 rs11075684 chr16:68582365 C/T cg04657470 chr2:198365150 HSPE1;HSPD1 0.57 6.71 0.35 8.68e-11 Ulcerative colitis; CRC cis rs7487075 0.780 rs1873793 chr12:46761324 A/G cg17501823 chr12:47219793 SLC38A4 -0.31 -5.6 -0.3 4.49e-8 Itch intensity from mosquito bite; CRC cis rs2836974 0.897 rs2836933 chr21:40564202 C/G cg11644478 chr21:40555479 PSMG1 0.81 12.21 0.56 1.56e-28 Cognitive function; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg01243544 chr1:227916373 LOC100130093 0.42 5.96 0.31 6.32e-9 Response to antipsychotic treatment; CRC cis rs7666738 0.830 rs13101352 chr4:98957544 C/T cg17366294 chr4:99064904 C4orf37 0.43 7.25 0.37 3.06e-12 Colonoscopy-negative controls vs population controls; CRC cis rs28386778 0.897 rs9912557 chr17:61784963 C/A cg00280220 chr17:61926910 NA 0.34 5.61 0.3 4.41e-8 Prudent dietary pattern; CRC trans rs1656966 1.000 rs1656966 chr3:186466252 C/T cg10130860 chr1:43124230 PPIH 0.42 6.33 0.33 7.93e-10 Myopia (pathological); CRC cis rs7428 0.545 rs17026212 chr2:85551696 T/G cg24342717 chr2:85555507 TGOLN2 -0.72 -11.97 -0.55 1.18e-27 Ear protrusion; CRC cis rs9926296 0.605 rs886952 chr16:89836781 G/A cg03388025 chr16:89894329 SPIRE2 0.44 8.82 0.44 6.89e-17 Vitiligo; CRC cis rs34599045 0.803 rs34198967 chr1:152869541 T/C cg07796016 chr1:152779584 LCE1C -0.75 -5.64 -0.3 3.71e-8 Parasitemia in Tripanosoma cruzi seropositivity; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg09502511 chr6:30539237 ABCF1 0.37 6.09 0.32 3.07e-9 Liver disease severity in Alagille syndrome; CRC cis rs7312774 0.618 rs28716736 chr12:107364410 A/G cg16260113 chr12:107380972 MTERFD3 0.88 8.67 0.43 1.94e-16 Severe influenza A (H1N1) infection; CRC cis rs11958404 0.932 rs6859470 chr5:157429505 T/G cg05962755 chr5:157440814 NA 1.01 12.88 0.58 5.12e-31 IgG glycosylation; CRC cis rs7945718 0.905 rs7124484 chr11:12745271 G/A cg25843174 chr11:12811716 TEAD1 0.48 9.11 0.45 8.31e-18 Educational attainment (years of education); CRC cis rs4820539 0.966 rs5759594 chr22:23470660 G/A cg14186256 chr22:23484241 RTDR1 0.92 18.38 0.71 2.04e-52 Bone mineral density; CRC cis rs763121 0.785 rs5757199 chr22:39040617 T/G cg06022373 chr22:39101656 GTPBP1 0.78 12.39 0.56 3.54e-29 Menopause (age at onset); CRC trans rs2303319 0.504 rs1515184 chr2:162561347 A/G cg18122310 chr12:50236657 BCDIN3D -0.74 -6.19 -0.32 1.81e-9 Cognitive function; CRC cis rs600806 0.854 rs3768496 chr1:109866569 T/A cg23032129 chr1:109941072 SORT1 -0.27 -5.8 -0.3 1.59e-8 Intelligence (multi-trait analysis); CRC cis rs4727027 0.901 rs10952792 chr7:148760501 C/T cg12479418 chr7:148823350 ZNF425;ZNF398 0.44 5.95 0.31 6.92e-9 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC cis rs780096 0.526 rs3845687 chr2:27689899 T/C cg02592271 chr2:27665507 KRTCAP3 -0.26 -5.78 -0.3 1.73e-8 Total body bone mineral density; CRC cis rs311392 0.871 rs402088 chr8:55092805 A/G cg06042504 chr8:55087323 NA -0.44 -6.82 -0.35 4.41e-11 Pelvic organ prolapse (moderate/severe); CRC cis rs9462027 0.628 rs9357181 chr6:34673833 C/T cg07306190 chr6:34760872 UHRF1BP1 0.35 6.28 0.33 1.1e-9 Systemic lupus erythematosus; CRC cis rs853679 0.517 rs9380055 chr6:28081629 A/G cg12963246 chr6:28129442 ZNF389 0.5 5.8 0.3 1.53e-8 Depression; CRC cis rs9611565 0.592 rs5758405 chr22:42076381 C/A cg06634786 chr22:41940651 POLR3H 0.52 6.13 0.32 2.47e-9 Vitiligo; CRC trans rs7937682 0.855 rs539693 chr11:111477387 A/G cg18187862 chr3:45730750 SACM1L 0.45 6.55 0.34 2.23e-10 Primary sclerosing cholangitis; CRC cis rs758324 0.812 rs116369002 chr5:131242055 G/A cg25547332 chr5:131281432 NA -0.36 -5.68 -0.3 3.01e-8 Alzheimer's disease in APOE e4- carriers; CRC cis rs61656020 1 rs61656020 chr16:1882221 C/G cg00046913 chr16:1877150 HAGH;FAHD1 -0.63 -6.93 -0.36 2.27e-11 Ankle injury; CRC cis rs2836974 0.897 rs13052882 chr21:40555351 G/C cg06238570 chr21:40685208 BRWD1 0.73 10.2 0.49 2.12e-21 Cognitive function; CRC cis rs59104589 0.617 rs3771566 chr2:242358299 G/T cg19488206 chr2:242435732 STK25 0.48 7.04 0.36 1.11e-11 Fibrinogen levels; CRC cis rs9914988 0.943 rs1035989 chr17:27143810 T/G cg12682573 chr17:27188876 MIR451;MIR144 0.57 7.99 0.4 2.37e-14 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs6952808 0.823 rs10950448 chr7:1966492 G/C cg00106254 chr7:1943704 MAD1L1 -0.52 -7.44 -0.38 8.66e-13 Bipolar disorder and schizophrenia; CRC cis rs7737355 0.812 rs6881486 chr5:130793836 C/T cg25547332 chr5:131281432 NA -0.36 -5.73 -0.3 2.29e-8 Life satisfaction; CRC cis rs4919694 1.000 rs17727044 chr10:104821256 A/T cg04362960 chr10:104952993 NT5C2 1.2 10.76 0.51 2.54e-23 Arsenic metabolism; CRC cis rs4727027 0.870 rs62507485 chr7:148764182 C/T cg12479418 chr7:148823350 ZNF425;ZNF398 0.46 6.29 0.33 1.03e-9 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC cis rs6860806 0.507 rs200837 chr5:131699958 G/A cg11843238 chr5:131593191 PDLIM4 0.43 7.22 0.37 3.62e-12 Breast cancer; CRC cis rs8053891 0.615 rs2000999 chr16:72108093 G/A cg23815491 chr16:72088622 HP 0.59 6.64 0.34 1.29e-10 Coronary artery disease; CRC cis rs11212617 0.967 rs620613 chr11:108185478 C/T cg14761454 chr11:108092087 ATM;NPAT 0.4 5.87 0.31 1.08e-8 Response to metformin in type 2 diabetes (glycemic); CRC cis rs10504229 0.683 rs77548248 chr8:58117542 G/A cg24829409 chr8:58192753 C8orf71 -0.54 -7.82 -0.4 7.48e-14 Developmental language disorder (linguistic errors); CRC cis rs7044106 0.708 rs959558 chr9:123368911 C/G cg09586646 chr9:123605570 PSMD5;LOC253039 0.54 8.01 0.4 2.05e-14 Hip circumference adjusted for BMI; CRC cis rs274567 0.550 rs272885 chr5:131667736 A/G cg27615366 chr5:131592974 PDLIM4 0.32 5.76 0.3 1.92e-8 Blood metabolite levels; CRC trans rs1973993 0.967 rs10875017 chr1:96949526 C/T cg10631902 chr5:14652156 NA 0.51 8.96 0.44 2.55e-17 Weight; CRC cis rs4713118 0.869 rs10214440 chr6:27702440 A/C cg12172441 chr6:28176163 NA 0.54 7.43 0.38 9.36e-13 Parkinson's disease; CRC trans rs10267593 0.516 rs62435159 chr7:1911281 G/A cg11693508 chr17:37793320 STARD3 0.55 7.17 0.37 4.92e-12 Coronary artery disease; CRC cis rs6933660 0.646 rs3736176 chr6:151773320 T/A cg02564969 chr6:151773285 C6orf211;RMND1 0.43 6.03 0.32 4.46e-9 Menarche (age at onset); CRC cis rs853679 0.517 rs34716816 chr6:28046169 C/A cg21251018 chr6:28226885 NKAPL 0.47 6.16 0.32 2.07e-9 Depression; CRC cis rs1953600 0.837 rs3098105 chr10:81953266 C/T cg00277334 chr10:82204260 NA 0.37 5.91 0.31 8.4e-9 Sarcoidosis; CRC cis rs7224685 0.501 rs781842 chr17:3958955 C/T cg10724054 chr17:3904396 NA -0.47 -7.98 -0.4 2.52e-14 Type 2 diabetes; CRC cis rs7264396 0.887 rs224343 chr20:34036699 A/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.43 -6.99 -0.36 1.54e-11 Total cholesterol levels; CRC cis rs1799949 0.965 rs8067269 chr17:41235799 C/T cg25072359 chr17:41440525 NA 0.51 7.99 0.4 2.28e-14 Menopause (age at onset); CRC cis rs11628318 0.614 rs12588817 chr14:103089210 G/A cg12046867 chr14:103022105 NA -0.43 -6.18 -0.32 1.88e-9 Platelet count; CRC cis rs11758351 0.660 rs55643278 chr6:26222888 C/A cg22723502 chr6:26240528 HIST1H4F -0.37 -5.91 -0.31 8.57e-9 Gout;Renal underexcretion gout; CRC cis rs28386778 0.897 rs2584601 chr17:61940977 T/C cg06873352 chr17:61820015 STRADA 0.73 13.4 0.59 5.5e-33 Prudent dietary pattern; CRC cis rs2223471 0.652 rs2744488 chr6:50768062 C/A cg03432817 chr6:50765336 NA 0.39 6.26 0.33 1.19e-9 Subcutaneous adipose tissue; CRC cis rs6951245 0.872 rs112309216 chr7:1100296 A/T cg22907277 chr7:1156413 C7orf50 0.73 7.68 0.39 1.78e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs1129187 0.755 rs9462855 chr6:42925936 G/C cg03790207 chr6:42947109 PEX6 -0.52 -7.65 -0.39 2.22e-13 Alzheimer's disease in APOE e4+ carriers; CRC cis rs877282 0.685 rs56234340 chr10:781339 A/G cg17470449 chr10:769945 NA 0.62 8.97 0.44 2.36e-17 Uric acid levels; CRC cis rs1552244 0.935 rs66493421 chr3:10092569 G/A cg18598329 chr3:10140678 FANCD2;C3orf24 -0.81 -9.18 -0.45 4.97e-18 Alzheimer's disease; CRC cis rs9611565 0.559 rs132768 chr22:42013523 C/A cg03806693 chr22:41940476 POLR3H 1.07 12.59 0.57 6.34e-30 Vitiligo; CRC trans rs9929218 0.608 rs35158985 chr16:68796746 A/G cg04657470 chr2:198365150 HSPE1;HSPD1 -0.68 -9.44 -0.46 7.31e-19 Colorectal cancer; CRC cis rs6484504 0.652 rs674035 chr11:31399014 G/A cg14844989 chr11:31128820 NA 0.34 5.9 0.31 8.98e-9 Red blood cell count; CRC cis rs4927850 1.000 rs10881563 chr3:195750225 A/G cg12923728 chr3:195709715 SDHAP1 -0.78 -11.97 -0.55 1.18e-27 Pancreatic cancer; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg07886691 chr10:64028545 RTKN2 0.42 6.4 0.33 5.26e-10 Intelligence (multi-trait analysis); CRC cis rs2197308 0.765 rs11182481 chr12:37926019 T/C cg13010199 chr12:38710504 ALG10B 0.44 5.85 0.31 1.18e-8 Morning vs. evening chronotype; CRC cis rs2976388 1.000 rs2920297 chr8:143763083 A/G cg24046110 chr8:143859143 LYNX1 -0.37 -6.32 -0.33 8.7e-10 Urinary tract infection frequency; CRC cis rs826838 0.967 rs7970069 chr12:38810631 T/C cg13010199 chr12:38710504 ALG10B 0.46 5.98 0.31 5.88e-9 Heart rate; CRC trans rs783540 0.967 rs17158390 chr15:83293028 A/G cg18393722 chr15:85113863 UBE2QP1 -0.36 -6.14 -0.32 2.36e-9 Schizophrenia; CRC cis rs2688608 0.592 rs7923045 chr10:75487498 A/T cg16540259 chr10:75572220 NDST2 0.37 5.84 0.31 1.28e-8 Inflammatory bowel disease; CRC cis rs7726839 0.561 rs72703046 chr5:580129 T/C cg16447950 chr5:562315 NA -0.85 -12.55 -0.57 8.97e-30 Obesity-related traits; CRC cis rs9515203 0.596 rs9521731 chr13:111032699 C/G cg15455643 chr13:111040242 COL4A2 0.42 6.76 0.35 6.37e-11 Coronary artery disease; CRC trans rs11098499 0.657 rs9996569 chr4:120299004 G/C cg25214090 chr10:38739885 LOC399744 0.62 9.74 0.47 7.35e-20 Corneal astigmatism; CRC cis rs9486715 0.793 rs2499777 chr6:97013814 T/C cg18709589 chr6:96969512 KIAA0776 -0.5 -7.39 -0.38 1.25e-12 Headache; CRC cis rs875971 0.830 rs6950137 chr7:65976610 G/A cg18876405 chr7:65276391 NA 0.5 8.28 0.42 3.19e-15 Aortic root size; CRC cis rs8177253 0.634 rs6798547 chr3:133448499 G/A cg16262614 chr3:133464971 TF 0.4 7.13 0.37 6.43e-12 Iron status biomarkers; CRC cis rs910316 0.726 rs61979167 chr14:75663610 C/T cg08847533 chr14:75593920 NEK9 -0.79 -13.05 -0.58 1.23e-31 Height; CRC cis rs13256369 1.000 rs13256369 chr8:8577379 T/C cg00074818 chr8:8560427 CLDN23 0.35 6.47 0.34 3.45e-10 Obesity-related traits; CRC cis rs10504229 1.000 rs73609762 chr8:58192695 A/G cg22535103 chr8:58192502 C8orf71 -0.82 -12.27 -0.56 9.63e-29 Developmental language disorder (linguistic errors); CRC trans rs7819412 0.522 rs3021495 chr8:10994743 C/G cg06636001 chr8:8085503 FLJ10661 -0.45 -6.09 -0.32 3.19e-9 Triglycerides; CRC cis rs2153535 0.580 rs1889715 chr6:8443475 G/A cg07606381 chr6:8435919 SLC35B3 0.67 10.81 0.51 1.71e-23 Motion sickness; CRC cis rs10857712 0.528 rs2265638 chr10:135217175 A/G cg19904058 chr10:135279010 LOC619207 -0.27 -5.64 -0.3 3.64e-8 Systemic lupus erythematosus; CRC trans rs2303319 0.504 rs62189054 chr2:162624654 C/G cg09481857 chr22:21368659 P2RX6;MGC16703 -0.64 -6.28 -0.33 1.08e-9 Cognitive function; CRC cis rs7618915 0.571 rs2251219 chr3:52584787 C/T cg08222913 chr3:52553049 STAB1 0.34 6.15 0.32 2.25e-9 Bipolar disorder; CRC cis rs3741151 0.656 rs73550316 chr11:73299799 G/A cg17517138 chr11:73019481 ARHGEF17 0.99 7.81 0.4 7.63e-14 GIP levels in response to oral glucose tolerance test (120 minutes); CRC cis rs6459804 1.000 rs6459806 chr7:157510483 C/G cg05731713 chr7:157510257 PTPRN2 0.48 8.08 0.41 1.26e-14 Bipolar disorder and schizophrenia; CRC cis rs9486719 1.000 rs13207333 chr6:96882254 T/C cg06623918 chr6:96969491 KIAA0776 -0.81 -9.51 -0.46 4.17e-19 Migraine;Coronary artery disease; CRC cis rs7804356 0.953 rs7785815 chr7:26852728 T/A cg03456212 chr7:26904342 SKAP2 -0.52 -5.68 -0.3 2.98e-8 Type 1 diabetes; CRC cis rs12220238 1.000 rs12256105 chr10:75909634 G/A cg19889307 chr10:75911429 ADK;AP3M1 0.64 6.42 0.33 4.71e-10 Soluble interleukin-2 receptor subunit alpha; CRC cis rs7591163 0.959 rs11685995 chr2:228722008 T/C cg21577049 chr2:228736449 WDR69 -0.44 -5.97 -0.31 6.27e-9 Blood pressure; CRC cis rs4819052 0.959 rs9976074 chr21:46655638 G/T cg02159808 chr21:46707872 POFUT2;LOC642852 0.6 6.97 0.36 1.77e-11 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs9322193 0.847 rs9505972 chr6:150096391 A/C cg05861140 chr6:150128134 PCMT1 -0.4 -6.12 -0.32 2.59e-9 Lung cancer; CRC cis rs1867631 0.585 rs4655642 chr1:67090083 A/G cg02459107 chr1:67143332 SGIP1 0.34 6.18 0.32 1.91e-9 Menopause (age at onset); CRC cis rs2297440 0.506 rs2236504 chr20:62224762 C/T cg09650180 chr20:62225654 GMEB2 -0.5 -6.67 -0.35 1.07e-10 Glioma;Non-glioblastoma glioma;Glioblastoma; CRC cis rs9457247 0.765 rs10946203 chr6:167446735 A/C cg23791538 chr6:167370224 RNASET2 -0.38 -5.71 -0.3 2.47e-8 Crohn's disease; CRC cis rs4713118 0.869 rs9283881 chr6:27715255 A/T cg12172441 chr6:28176163 NA 0.53 7.33 0.37 1.85e-12 Parkinson's disease; CRC cis rs7493 0.755 rs17883791 chr7:94999438 G/A cg17330251 chr7:94953956 PON1 -0.52 -6.64 -0.34 1.26e-10 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs4713118 0.824 rs7759217 chr6:27730463 A/G cg15845792 chr6:28175446 NA 0.65 8.49 0.42 7.04e-16 Parkinson's disease; CRC cis rs929354 0.772 rs6459739 chr7:156998863 A/T cg17757837 chr7:157058334 UBE3C 0.74 12.6 0.57 5.83e-30 Body mass index; CRC cis rs3892630 0.588 rs7260037 chr19:33242701 G/A cg22980127 chr19:33182716 NUDT19 0.92 12.32 0.56 6.34e-29 Red blood cell traits; CRC cis rs775227 0.574 rs34049435 chr3:113099499 C/T cg18753928 chr3:113234510 CCDC52 -0.55 -6.71 -0.35 8.41e-11 Dental caries; CRC cis rs10911251 0.546 rs2027084 chr1:183110801 G/A ch.1.3577855R chr1:183094577 LAMC1 0.83 14.65 0.63 9.3e-38 Colorectal cancer; CRC cis rs61774743 0.521 rs60144015 chr1:41845246 C/A cg24596898 chr1:41849189 NA 0.34 5.66 0.3 3.25e-8 Intelligence (multi-trait analysis); CRC cis rs372883 0.600 rs2832294 chr21:30739671 A/C cg24692254 chr21:30365293 RNF160 0.64 9.8 0.48 4.68e-20 Pancreatic cancer; CRC cis rs10504229 0.728 rs17804774 chr8:58155950 G/T cg22535103 chr8:58192502 C8orf71 -0.7 -8.41 -0.42 1.3e-15 Developmental language disorder (linguistic errors); CRC cis rs12451471 0.637 rs12452616 chr17:78090081 A/G cg12326244 chr17:78078995 GAA 0.37 5.66 0.3 3.3e-8 Plateletcrit;Mean corpuscular hemoglobin concentration; CRC cis rs10256972 0.521 rs10280960 chr7:1103697 A/G cg03188948 chr7:1209495 NA 0.38 5.76 0.3 1.95e-8 Longevity;Endometriosis; CRC cis rs10170846 0.893 rs10932967 chr2:223544111 C/T cg25565276 chr2:223520875 FARSB 0.53 7.25 0.37 3.08e-12 Schizophrenia (inflammation and infection response interaction); CRC cis rs9326248 0.861 rs494356 chr11:117071970 T/C cg26566898 chr11:117069891 TAGLN 0.39 6.2 0.32 1.66e-9 Blood protein levels; CRC cis rs3806843 0.547 rs246054 chr5:140326159 G/A cg19875535 chr5:140030758 IK 0.39 6.02 0.31 4.67e-9 Depressive symptoms (multi-trait analysis); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg17487170 chr5:133451259 TCF7 0.38 6.62 0.34 1.5e-10 Liver disease severity in Alagille syndrome; CRC cis rs1065852 0.526 rs9611700 chr22:42401514 C/T cg00645731 chr22:42541494 CYP2D7P1 0.4 6.89 0.36 2.79e-11 Response to serotonin reuptake inhibitors in major depressive disorder (plasma drug and metabolite levels); CRC cis rs6500602 0.701 rs4786508 chr16:4568043 G/A cg08645402 chr16:4508243 NA 0.59 8.77 0.44 1.01e-16 Schizophrenia; CRC cis rs6952808 0.760 rs34961072 chr7:1948620 G/C cg04267008 chr7:1944627 MAD1L1 -0.83 -12.12 -0.56 3.46e-28 Bipolar disorder and schizophrenia; CRC cis rs6696846 0.791 rs11240352 chr1:205051711 C/G cg00857998 chr1:205179979 DSTYK -0.47 -6.55 -0.34 2.26e-10 Red blood cell count; CRC trans rs10411161 0.702 rs75647161 chr19:52398984 T/C cg22319618 chr22:45562946 NUP50 -0.58 -6.01 -0.31 4.92e-9 Breast cancer; CRC cis rs10946940 0.965 rs62401383 chr6:27564547 C/T cg08798685 chr6:27730294 NA 0.39 5.92 0.31 7.97e-9 Systemic lupus erythematosus; CRC cis rs7223966 1.000 rs16947005 chr17:61702989 C/T cg05941027 chr17:61774174 LIMD2 -0.35 -6.54 -0.34 2.33e-10 Hip circumference adjusted for BMI;Body mass index; CRC cis rs7044106 0.791 rs10818473 chr9:123484155 A/C cg09586646 chr9:123605570 PSMD5;LOC253039 0.7 10.27 0.49 1.19e-21 Hip circumference adjusted for BMI; CRC cis rs3741404 0.583 rs640999 chr11:63869425 C/A cg18225595 chr11:63971243 STIP1 0.41 6.61 0.34 1.52e-10 Platelet count; CRC cis rs1018836 0.923 rs7826178 chr8:91649592 C/A cg16814680 chr8:91681699 NA -0.81 -13.09 -0.59 8.14e-32 Ejection fraction in Tripanosoma cruzi seropositivity; CRC cis rs2290405 0.527 rs7663192 chr4:923947 T/C cg12601576 chr4:906860 GAK -0.45 -6.3 -0.33 9.45e-10 Systemic sclerosis; CRC cis rs6502050 0.698 rs67143649 chr17:80117772 C/G cg11859384 chr17:80120422 CCDC57 -0.37 -5.9 -0.31 8.99e-9 Life satisfaction; CRC cis rs1950626 0.623 rs34448411 chr14:101429287 G/A cg02351406 chr14:101447389 SNORD114-20;SNORD114-21 0.73 11.47 0.53 7.56e-26 Pelvic organ prolapse (moderate/severe); CRC cis rs4285028 0.747 rs77790376 chr3:121492211 C/T cg20356878 chr3:121714668 ILDR1 -0.51 -6.59 -0.34 1.73e-10 Multiple sclerosis; CRC cis rs2739330 0.761 rs5760176 chr22:24402321 A/G cg10150615 chr22:24372951 LOC391322 0.52 7.83 0.4 6.71e-14 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs9916302 0.904 rs8070695 chr17:37478062 C/T cg15445000 chr17:37608096 MED1 -0.4 -8.64 -0.43 2.46e-16 Glomerular filtration rate (creatinine); CRC cis rs9435341 1.000 rs1762484 chr1:107613923 A/C cg15468180 chr1:107600409 PRMT6 -0.42 -6.36 -0.33 6.79e-10 Facial morphology (factor 21, depth of nasal alae); CRC cis rs4150161 0.591 rs3759977 chr16:84221170 T/A cg10106505 chr16:84220380 TAF1C -1.13 -9.37 -0.46 1.24e-18 Systolic blood pressure response to hydrochlorothiazide in hypertension; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg22643867 chr2:131148877 NA 0.48 6.42 0.33 4.82e-10 Thyroid stimulating hormone; CRC trans rs2228479 0.850 rs17226519 chr16:89839854 T/C cg24644049 chr4:85504048 CDS1 0.9 7.57 0.39 3.72e-13 Skin colour saturation; CRC cis rs1552244 1.000 rs9881859 chr3:10072814 A/T cg18598329 chr3:10140678 FANCD2;C3orf24 -0.89 -12.22 -0.56 1.39e-28 Alzheimer's disease; CRC cis rs28386778 0.863 rs3760254 chr17:61851751 T/G cg25654072 chr17:61904446 PSMC5;FTSJ3 0.71 11.06 0.52 2.21e-24 Prudent dietary pattern; CRC cis rs950776 0.518 rs12906951 chr15:78825562 C/T cg06917634 chr15:78832804 PSMA4 0.66 10.42 0.5 3.55e-22 Sudden cardiac arrest; CRC trans rs2303319 0.504 rs12469302 chr2:162433831 G/T cg00039960 chr17:7142925 PHF23 -0.73 -6.0 -0.31 5.26e-9 Cognitive function; CRC cis rs7312933 0.703 rs2406567 chr12:42551479 G/C cg11827402 chr12:42719852 PPHLN1;ZCRB1 0.63 8.79 0.44 8.37e-17 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CRC cis rs7586879 0.789 rs13428763 chr2:25132855 T/G cg22495460 chr2:25135724 ADCY3 -0.9 -15.21 -0.64 6e-40 Body mass index; CRC trans rs2727020 0.521 rs10839285 chr11:49496852 T/G cg15704280 chr7:45808275 SEPT13 0.74 10.19 0.49 2.18e-21 Coronary artery disease; CRC cis rs9311474 0.659 rs1133415 chr3:52575831 G/A cg15147215 chr3:52552868 STAB1 -0.7 -12.91 -0.58 3.99e-31 Electroencephalogram traits; CRC cis rs3818285 0.610 rs642938 chr10:111633025 A/C cg00817464 chr10:111662876 XPNPEP1 0.63 11.07 0.52 1.97e-24 Superior crus of antihelix expression; CRC cis rs1051424 0.651 rs1292063 chr17:57907768 T/A cg13753209 chr17:57696993 CLTC -0.46 -5.85 -0.31 1.16e-8 Obesity-related traits; CRC cis rs9814567 1.000 rs4572812 chr3:134291177 G/T cg06109529 chr3:134205091 CEP63;ANAPC13 0.83 12.18 0.56 1.98e-28 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs11971779 0.555 rs4728466 chr7:139096365 T/C cg23387468 chr7:139079360 LUC7L2 0.41 7.05 0.36 1.04e-11 Diisocyanate-induced asthma; CRC cis rs600626 0.529 rs2004638 chr11:75471012 C/T cg24262691 chr11:75473276 NA 0.53 8.17 0.41 6.68e-15 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CRC cis rs17666538 1.000 rs61064968 chr8:587933 T/C cg26554054 chr8:600488 NA -0.66 -6.11 -0.32 2.85e-9 IgG glycosylation; CRC trans rs1814175 0.715 rs11040586 chr11:49858432 T/A cg11707556 chr5:10655725 ANKRD33B -0.42 -7.87 -0.4 5.18e-14 Height; CRC cis rs2242116 0.796 rs7623898 chr3:46974172 C/T cg27129171 chr3:47204927 SETD2 -0.63 -9.14 -0.45 6.63e-18 Birth weight; CRC cis rs1403694 0.695 rs3774292 chr3:186433574 A/T cg04611788 chr3:186434169 KNG1 -0.61 -9.13 -0.45 7.33e-18 Blood protein levels; CRC cis rs10504229 0.679 rs72649109 chr8:58031274 A/T cg02290350 chr8:58132656 NA -0.56 -6.57 -0.34 1.96e-10 Developmental language disorder (linguistic errors); CRC cis rs7666738 0.830 rs7674095 chr4:99048158 T/A cg17366294 chr4:99064904 C4orf37 0.45 7.75 0.39 1.16e-13 Colonoscopy-negative controls vs population controls; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg05655935 chr10:93683722 BTAF1 -0.39 -6.04 -0.32 4.24e-9 Myopia (pathological); CRC cis rs4731207 0.698 rs35184624 chr7:124469587 G/A cg23710748 chr7:124431027 NA 0.38 6.08 0.32 3.42e-9 Cutaneous malignant melanoma; CRC cis rs425277 0.606 rs2503705 chr1:2076741 A/G cg03732007 chr1:2071316 PRKCZ 0.41 6.74 0.35 7.13e-11 Height; CRC cis rs11098499 0.863 rs7699064 chr4:120428309 A/G cg09307838 chr4:120376055 NA -0.67 -9.95 -0.48 1.49e-20 Corneal astigmatism; CRC cis rs7811142 1.000 rs11769700 chr7:100090049 T/C cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.17 17.06 0.69 3.29e-47 Platelet count; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg02902865 chr1:12679132 DHRS3 0.43 6.14 0.32 2.36e-9 Response to antipsychotic treatment; CRC cis rs965469 1.000 rs6051709 chr20:3263685 T/C cg25506879 chr20:3388711 C20orf194 -0.38 -5.63 -0.3 3.77e-8 IFN-related cytopenia; CRC cis rs1448094 0.512 rs6539924 chr12:86236935 T/C cg18827107 chr12:86230957 RASSF9 -0.47 -7.82 -0.4 7.27e-14 Major depressive disorder; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg19359929 chr1:3541763 TPRG1L 0.45 6.15 0.32 2.2e-9 Anxiety disorder; CRC cis rs853679 0.517 rs9380052 chr6:28064623 A/G cg18032046 chr6:28092343 ZSCAN16 -0.54 -6.37 -0.33 6.45e-10 Depression; CRC cis rs6426558 0.537 rs6662583 chr1:227383889 A/G cg10327440 chr1:227177885 CDC42BPA -0.4 -6.09 -0.32 3.19e-9 Neutrophil percentage of white cells; CRC cis rs57677839 1 rs57677839 chr11:17028189 G/A cg15378786 chr11:17036137 PLEKHA7 0.88 16.39 0.67 1.53e-44 Coronary artery disease; CRC trans rs7267979 1.000 rs6050632 chr20:25432601 A/G cg17903999 chr18:56338584 MALT1 -0.42 -6.98 -0.36 1.6e-11 Liver enzyme levels (alkaline phosphatase); CRC cis rs7666738 0.830 rs1813972 chr4:98886828 C/A cg17366294 chr4:99064904 C4orf37 0.42 6.83 0.35 4.15e-11 Colonoscopy-negative controls vs population controls; CRC cis rs3816788 0.774 rs11784816 chr8:21773500 C/T cg08288130 chr8:21771540 DOK2 -0.28 -5.72 -0.3 2.4e-8 Lung cancer in ever smokers; CRC trans rs1814175 0.702 rs4881644 chr11:49786367 C/T cg11707556 chr5:10655725 ANKRD33B -0.42 -7.85 -0.4 5.82e-14 Height; CRC cis rs9372498 0.536 rs25422 chr6:118807847 A/G cg22561889 chr6:118971681 C6orf204 -0.51 -6.22 -0.32 1.5e-9 Diastolic blood pressure; CRC cis rs17092148 0.887 rs6058104 chr20:33271052 G/A cg08999081 chr20:33150536 PIGU 0.49 5.92 0.31 8.12e-9 Neuroticism; CRC cis rs6942756 0.806 rs2718096 chr7:128951000 A/G cg02491457 chr7:128862824 NA 0.62 8.84 0.44 6.12e-17 White matter hyperintensity burden; CRC cis rs4332037 0.707 rs10268797 chr7:1873756 C/G cg23378565 chr7:2036160 MAD1L1 0.4 5.99 0.31 5.39e-9 Bipolar disorder; CRC cis rs10875943 0.751 rs56222401 chr12:49672714 A/G cg17570948 chr12:49726661 C1QL4 -0.35 -5.95 -0.31 6.85e-9 Prostate cancer; CRC cis rs12530845 0.623 rs73721662 chr7:135341314 G/A cg23117316 chr7:135346802 PL-5283 -0.45 -5.81 -0.3 1.48e-8 Red blood cell traits; CRC trans rs2303319 0.504 rs35304298 chr2:162617185 G/T cg04551154 chr10:95462393 C10orf4 -0.74 -6.34 -0.33 7.76e-10 Cognitive function; CRC cis rs11098499 0.909 rs10014719 chr4:120320715 G/A cg24375607 chr4:120327624 NA 0.5 7.66 0.39 2.07e-13 Corneal astigmatism; CRC trans rs2303319 0.504 rs62187656 chr2:162487699 A/G cg22988483 chr14:93581567 ITPK1 -0.67 -6.03 -0.32 4.48e-9 Cognitive function; CRC cis rs9534288 0.700 rs4942466 chr13:46597190 A/G cg15192986 chr13:46630673 CPB2 -0.65 -9.8 -0.48 4.5e-20 Blood protein levels; CRC cis rs4838594 0.549 rs11101333 chr10:49668179 A/G cg17291251 chr10:49678358 ARHGAP22 0.42 6.63 0.34 1.41e-10 Daytime sleep phenotypes; CRC cis rs28386778 0.897 rs2028567 chr17:61915326 G/A cg06873352 chr17:61820015 STRADA 0.79 14.89 0.63 1.12e-38 Prudent dietary pattern; CRC cis rs9381040 0.610 rs2268196 chr6:41021950 C/G cg09580153 chr6:41068724 NFYA;LOC221442 0.43 6.3 0.33 9.37e-10 Alzheimer's disease (late onset); CRC cis rs754466 0.651 rs11002317 chr10:79617648 G/A cg26805224 chr10:79626177 DLG5 -0.56 -8.34 -0.42 2.12e-15 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs17376456 0.825 rs10054903 chr5:93281491 C/A cg09848695 chr5:92956644 FAM172A;MIR2277 0.68 6.03 0.32 4.45e-9 Diabetic retinopathy; CRC cis rs995000 0.931 rs1748197 chr1:63056112 G/A cg19896129 chr1:63156450 NA 0.42 6.57 0.34 1.96e-10 Triglyceride levels; CRC cis rs477692 0.637 rs2388331 chr10:131314173 G/A cg05714579 chr10:131428358 MGMT 0.52 7.32 0.37 1.92e-12 Response to temozolomide; CRC cis rs6754311 0.731 rs309168 chr2:136670298 C/T cg15123519 chr2:136567270 LCT -0.33 -6.32 -0.33 8.57e-10 Mosquito bite size; CRC cis rs11583043 0.575 rs12727971 chr1:101589175 A/G cg16556008 chr1:101360663 SLC30A7;EXTL2 0.46 5.95 0.31 6.92e-9 Ulcerative colitis;Inflammatory bowel disease; CRC cis rs3820068 0.705 rs16851731 chr1:15860240 A/G cg27534772 chr1:16042836 PLEKHM2 0.41 6.99 0.36 1.54e-11 Systolic blood pressure; CRC cis rs2717559 0.542 rs2717586 chr8:143897882 C/T cg15511327 chr8:143859410 LYNX1 0.6 10.39 0.5 4.7e-22 Urinary tract infection frequency; CRC cis rs9910055 0.683 rs7220138 chr17:42254011 C/G cg16434002 chr17:42200994 HDAC5 -0.52 -7.52 -0.38 5.4e-13 Total body bone mineral density; CRC cis rs858239 0.831 rs7796541 chr7:23389073 G/T cg00469287 chr7:23338798 C7orf30 0.43 5.86 0.31 1.11e-8 Cerebrospinal fluid biomarker levels; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg00373131 chr1:93646396 CCDC18;TMED5 0.43 6.65 0.34 1.24e-10 Liver disease severity in Alagille syndrome; CRC cis rs600231 0.542 rs11227198 chr11:65237974 G/A cg17120908 chr11:65337727 SSSCA1 -0.68 -7.56 -0.38 4.09e-13 Bone mineral density; CRC cis rs853679 0.517 rs9380050 chr6:28048538 A/G cg18032046 chr6:28092343 ZSCAN16 -0.5 -5.89 -0.31 9.74e-9 Depression; CRC cis rs2880765 0.835 rs4281668 chr15:86047286 C/T cg17133734 chr15:86042851 AKAP13 0.38 6.37 0.33 6.19e-10 Coronary artery disease; CRC cis rs2274273 0.662 rs67958555 chr14:55670866 G/A cg10130446 chr14:55658398 DLGAP5 -0.43 -5.81 -0.31 1.46e-8 Protein biomarker; CRC cis rs2404602 0.735 rs2436996 chr15:76817420 C/T cg23625390 chr15:77176239 SCAPER -0.82 -12.68 -0.57 2.74e-30 Blood metabolite levels; CRC cis rs7618915 0.547 rs2286800 chr3:52778051 C/T cg07507251 chr3:52567010 NT5DC2 0.44 6.39 0.33 5.81e-10 Bipolar disorder; CRC cis rs7503807 0.905 rs9909449 chr17:78614393 A/G cg09596252 chr17:78655493 RPTOR 0.41 6.41 0.33 5.18e-10 Obesity; CRC cis rs7918232 0.830 rs9833 chr10:27400861 G/A cg14442939 chr10:27389572 ANKRD26 0.81 8.94 0.44 2.9e-17 Breast cancer; CRC cis rs344364 0.511 rs62040569 chr16:1948137 C/T cg00046913 chr16:1877150 HAGH;FAHD1 -0.58 -6.06 -0.32 3.66e-9 Glomerular filtration rate in chronic kidney disease; CRC cis rs2346177 0.605 rs7556828 chr2:46663172 A/G cg26688816 chr2:46740690 ATP6V1E2 0.61 9.83 0.48 3.73e-20 HDL cholesterol; CRC cis rs9943753 0.508 rs7958071 chr12:109836089 G/A cg19025524 chr12:109796872 NA -0.52 -8.01 -0.4 2.07e-14 HDL cholesterol; CRC cis rs9399135 0.967 rs9389253 chr6:135329755 T/C cg22676075 chr6:135203613 NA 0.41 6.35 0.33 7.03e-10 Red blood cell count; CRC cis rs644148 0.748 rs542150 chr19:44967453 T/C cg15540054 chr19:45004280 ZNF180 0.55 7.13 0.37 6.29e-12 Personality dimensions; CRC cis rs9649213 0.614 rs3944111 chr7:98005766 C/T cg09267113 chr7:98030324 BAIAP2L1 -0.95 -12.87 -0.58 5.41e-31 Prostate cancer (SNP x SNP interaction); CRC cis rs10256972 0.521 rs871019 chr7:1105230 A/G cg16145915 chr7:1198662 ZFAND2A -0.33 -6.79 -0.35 5.19e-11 Longevity;Endometriosis; CRC cis rs910316 0.967 rs12890371 chr14:75593839 T/C cg08847533 chr14:75593920 NEK9 0.95 18.41 0.71 1.56e-52 Height; CRC cis rs6912958 0.712 rs2814712 chr6:88396322 A/C cg08069147 chr6:88032118 GJB7;C6orf162 0.53 7.82 0.4 7.36e-14 Monocyte percentage of white cells; CRC cis rs4819052 0.959 rs8130866 chr21:46672112 G/A cg11663144 chr21:46675770 NA -0.78 -11.92 -0.55 1.8e-27 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs1003719 0.680 rs2835664 chr21:38573429 G/A cg10648535 chr21:38446584 PIGP;TTC3 -0.45 -6.23 -0.32 1.41e-9 Eye color traits; CRC cis rs6840360 0.642 rs11729923 chr4:152392036 G/T cg09659197 chr4:152720779 NA 0.34 6.64 0.34 1.27e-10 Intelligence (multi-trait analysis); CRC cis rs6751744 0.513 rs6738215 chr2:160453305 C/T cg08347373 chr2:160653686 CD302 -0.38 -6.27 -0.33 1.13e-9 Dysphagia; CRC cis rs77106637 0.860 rs11603334 chr11:72432985 G/A cg03713592 chr11:72463424 ARAP1 1.15 11.25 0.53 4.71e-25 Type 2 diabetes; CRC cis rs4523957 0.583 rs2984942 chr17:2030155 A/G cg16513277 chr17:2031491 SMG6 -0.66 -11.56 -0.54 3.69e-26 Autism spectrum disorder or schizophrenia;Schizophrenia; CRC cis rs3772130 1.000 rs13087578 chr3:121369207 A/C cg20356878 chr3:121714668 ILDR1 0.5 7.77 0.39 9.97e-14 Cognitive performance; CRC cis rs7249142 0.549 rs2238667 chr19:19282523 G/A cg12558012 chr19:19281197 LOC729991-MEF2B;MEF2B 0.58 8.92 0.44 3.32e-17 IgG glycosylation; CRC cis rs7586879 0.789 rs13404163 chr2:25126616 A/G cg22495460 chr2:25135724 ADCY3 -0.89 -15.02 -0.64 3.53e-39 Body mass index; CRC cis rs10782582 0.593 rs74968421 chr1:76233496 T/C cg03433033 chr1:76189801 ACADM -0.44 -6.43 -0.33 4.46e-10 Daytime sleep phenotypes; CRC cis rs1448094 0.512 rs1584368 chr12:86245117 A/C cg00310523 chr12:86230176 RASSF9 0.34 5.69 0.3 2.74e-8 Major depressive disorder; CRC cis rs7666738 0.830 rs4441757 chr4:98927059 T/C cg17366294 chr4:99064904 C4orf37 0.43 7.32 0.37 1.95e-12 Colonoscopy-negative controls vs population controls; CRC cis rs12130219 0.500 rs4845737 chr1:152177539 G/A cg17718321 chr1:152188247 HRNR -0.35 -7.5 -0.38 5.84e-13 Inflammatory skin disease; CRC cis rs644799 1.000 rs10831431 chr11:95510089 C/T cg03916912 chr11:95522834 CEP57;FAM76B 0.96 18.02 0.7 5.41e-51 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs10256972 0.553 rs4236381 chr7:1165723 A/C cg09177884 chr7:1199841 ZFAND2A -0.47 -6.75 -0.35 6.64e-11 Longevity;Endometriosis; CRC cis rs57561814 0.826 rs116542785 chr7:22747720 G/A cg26061582 chr7:22766209 IL6 0.69 5.92 0.31 7.91e-9 Tonsillectomy; CRC cis rs8072100 0.607 rs9894594 chr17:45461383 A/G cg08085267 chr17:45401833 C17orf57 -0.59 -9.01 -0.44 1.68e-17 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs8044868 0.530 rs2287999 chr16:72059149 A/G cg06172871 chr16:72088244 HP 0.39 5.69 0.3 2.82e-8 Body mass index (change over time) in cancer or chronic obstructive pulmonary disease;Body mass index (change over time) in cancer; CRC cis rs9916302 0.706 rs1054488 chr17:37687968 A/G cg15445000 chr17:37608096 MED1 0.36 6.27 0.33 1.12e-9 Glomerular filtration rate (creatinine); CRC cis rs2731664 0.792 rs2630767 chr5:176870700 T/C cg23176889 chr5:176863531 GRK6 -0.75 -16.64 -0.68 1.49e-45 Intelligence (multi-trait analysis); CRC trans rs853679 0.882 rs9380064 chr6:28143118 A/G cg06606381 chr12:133084897 FBRSL1 -0.92 -7.54 -0.38 4.53e-13 Depression; CRC cis rs79349575 0.721 rs3744608 chr17:46993233 C/G cg00947319 chr17:47005597 UBE2Z -0.34 -5.81 -0.3 1.5e-8 Type 2 diabetes; CRC cis rs1192414 0.515 rs6688706 chr1:92056144 A/C cg24006770 chr1:92056542 NA 0.57 9.56 0.47 2.97e-19 Vertical cup-disc ratio; CRC cis rs875971 0.964 rs778735 chr7:65814809 C/A cg12463550 chr7:65579703 CRCP 0.5 7.22 0.37 3.58e-12 Aortic root size; CRC cis rs11098499 0.954 rs56270433 chr4:120406030 C/T cg09307838 chr4:120376055 NA 0.7 11.0 0.52 3.69e-24 Corneal astigmatism; CRC cis rs4728142 0.564 rs10954213 chr7:128589427 G/A cg06630958 chr7:128577819 IRF5 -0.35 -5.79 -0.3 1.68e-8 Inflammatory bowel disease;Systemic lupus erythematosus;Ulcerative colitis; CRC cis rs898097 0.756 rs11655103 chr17:80813467 T/C cg19046167 chr17:80928561 B3GNTL1 -0.41 -6.5 -0.34 2.9e-10 Breast cancer; CRC cis rs8062405 0.755 rs7193402 chr16:28586127 A/G cg05139728 chr16:28306816 SBK1 -0.37 -6.1 -0.32 3e-9 Cognitive ability (multi-trait analysis);Cognitive ability; CRC cis rs10256972 0.681 rs12702016 chr7:1129392 C/T cg03923535 chr7:1197113 ZFAND2A 0.64 9.17 0.45 5.39e-18 Longevity;Endometriosis; CRC cis rs12586317 0.576 rs10130047 chr14:35633580 C/A cg07166546 chr14:35805898 NA -0.29 -5.69 -0.3 2.78e-8 Psoriasis; CRC cis rs514406 0.929 rs11206035 chr1:53323571 T/C cg08859206 chr1:53392774 SCP2 -0.45 -7.04 -0.36 1.13e-11 Monocyte count; CRC trans rs3733585 0.773 rs13107466 chr4:10019390 G/A cg26043149 chr18:55253948 FECH 0.51 7.91 0.4 3.95e-14 Cleft plate (environmental tobacco smoke interaction); CRC cis rs2386661 0.712 rs11259544 chr10:5646708 T/C cg17085576 chr10:5658249 NA -0.42 -6.11 -0.32 2.84e-9 Breast cancer; CRC cis rs9457247 0.765 rs10484531 chr6:167454434 G/A cg07741184 chr6:167504864 NA 0.39 6.57 0.34 1.98e-10 Crohn's disease; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg14242460 chr6:5261506 LYRM4;FARS2 0.38 6.19 0.32 1.81e-9 Liver disease severity in Alagille syndrome; CRC cis rs79839061 0.610 rs3736089 chr4:870118 G/A cg14530993 chr4:882597 GAK 0.82 7.8 0.4 8.21e-14 Intelligence (multi-trait analysis); CRC cis rs35146811 0.735 rs1637001 chr7:99808151 G/A cg13334819 chr7:99746414 C7orf59 0.52 6.82 0.35 4.46e-11 Coronary artery disease; CRC cis rs5750830 0.649 rs4821893 chr22:39797779 G/A cg25956985 chr22:39795188 MAP3K7IP1 -0.47 -6.75 -0.35 6.56e-11 Intelligence (multi-trait analysis); CRC trans rs58106596 0.800 rs28883318 chr2:232562935 G/A cg01370599 chr3:116745421 NA 0.53 7.24 0.37 3.26e-12 White blood cell count;Lymphocyte counts; CRC cis rs4409675 0.576 rs10794507 chr1:28216072 T/C cg23691781 chr1:28212827 C1orf38 0.33 7.76 0.39 1.06e-13 Corneal astigmatism; CRC cis rs16867321 0.614 rs10204086 chr2:181449668 G/T cg23363182 chr2:181467187 NA -0.61 -9.34 -0.46 1.51e-18 Obesity; CRC cis rs2239547 0.603 rs7644973 chr3:53082937 C/T cg11645453 chr3:52864694 ITIH4 0.5 8.33 0.42 2.17e-15 Schizophrenia; CRC cis rs7412746 0.611 rs2864873 chr1:150814174 A/G cg15448220 chr1:150897856 SETDB1 0.53 7.42 0.38 1.04e-12 Melanoma; CRC cis rs4819052 1.000 rs9306123 chr21:46709922 A/G cg02159808 chr21:46707872 POFUT2;LOC642852 0.64 7.79 0.39 8.98e-14 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs2032447 0.714 rs199726 chr6:25953360 G/A cg04800585 chr6:26043546 HIST1H2BB 0.49 7.34 0.38 1.68e-12 Intelligence (multi-trait analysis); CRC cis rs1448094 0.511 rs10735486 chr12:86154352 T/A cg25456477 chr12:86230367 RASSF9 -0.34 -5.87 -0.31 1.09e-8 Major depressive disorder; CRC cis rs9828933 0.832 rs3774723 chr3:63962339 G/A cg16258503 chr3:63850278 ATXN7;THOC7 -0.58 -6.59 -0.34 1.7e-10 Type 2 diabetes; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg11604272 chr11:65769511 EIF1AD;BANF1 0.43 6.01 0.31 4.86e-9 Response to antipsychotic treatment; CRC cis rs2797160 1.000 rs2747717 chr6:126008435 A/G cg05901451 chr6:126070800 HEY2 0.4 6.2 0.32 1.65e-9 Endometrial cancer; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg23200970 chr4:111119917 ELOVL6 0.41 6.89 0.36 2.87e-11 Liver disease severity in Alagille syndrome; CRC cis rs2836950 0.565 rs7276046 chr21:40581293 T/C cg11644478 chr21:40555479 PSMG1 -0.5 -7.49 -0.38 6.24e-13 Menarche (age at onset); CRC cis rs9902453 0.817 rs4294865 chr17:28205736 C/T cg26525008 chr17:28256777 EFCAB5;SSH2 0.56 8.14 0.41 8.46e-15 Coffee consumption (cups per day); CRC cis rs889398 0.617 rs6499265 chr16:69897998 G/A cg00738113 chr16:70207722 CLEC18C -0.35 -6.22 -0.32 1.49e-9 Body mass index; CRC cis rs12190007 0.547 rs3006181 chr6:169809117 T/A cg15038512 chr6:170123185 PHF10 -0.39 -6.05 -0.32 3.86e-9 Obesity-related traits; CRC cis rs3812762 0.833 rs10500705 chr11:8805261 A/G cg00186954 chr11:8933980 ST5;C11orf17 -0.43 -6.87 -0.35 3.12e-11 Hypospadias; CRC cis rs597539 0.652 rs592697 chr11:68650064 G/A cg06028808 chr11:68637592 NA 0.4 6.34 0.33 7.42e-10 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC trans rs11098499 0.789 rs10212719 chr4:120254437 T/C cg25214090 chr10:38739885 LOC399744 0.52 8.13 0.41 8.94e-15 Corneal astigmatism; CRC cis rs12760731 0.720 rs35905053 chr1:178441618 A/T cg00404053 chr1:178313656 RASAL2 0.95 9.93 0.48 1.66e-20 Obesity-related traits; CRC cis rs17253792 0.822 rs75560658 chr14:56079896 C/T cg01858014 chr14:56050164 KTN1 -0.87 -7.23 -0.37 3.34e-12 Putamen volume; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg18159463 chr10:104210483 C10orf95 0.43 6.1 0.32 2.96e-9 Anxiety disorder; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg22336633 chr11:17099688 RPS13 0.48 6.34 0.33 7.58e-10 Thyroid stimulating hormone; CRC cis rs8180040 1.000 rs811115 chr3:47322133 C/T cg10298567 chr3:47292165 KIF9 -0.4 -6.72 -0.35 7.9e-11 Colorectal cancer; CRC cis rs10504229 0.683 rs7822631 chr8:58130916 C/G cg02725872 chr8:58115012 NA -0.64 -11.55 -0.54 3.85e-26 Developmental language disorder (linguistic errors); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg16350314 chr8:27169081 TRIM35;PTK2B 0.44 6.34 0.33 7.62e-10 Response to antipsychotic treatment; CRC cis rs67478160 0.634 rs2368558 chr14:104230518 A/G cg01849466 chr14:104193079 ZFYVE21 -0.56 -10.47 -0.5 2.58e-22 Schizophrenia; CRC cis rs1552172 0.887 rs12725120 chr1:145661313 C/T cg11743829 chr1:145714124 CD160 -0.41 -6.18 -0.32 1.91e-9 Breast cancer; CRC cis rs17345786 1.000 rs3804775 chr3:101306507 C/T cg12386194 chr3:101231763 SENP7 0.53 7.22 0.37 3.68e-12 Colonoscopy-negative controls vs population controls; CRC cis rs870825 0.616 rs6552806 chr4:185638231 C/T cg04058563 chr4:185651563 MLF1IP 0.73 9.38 0.46 1.13e-18 Blood protein levels; CRC cis rs2839186 0.708 rs6518285 chr21:47644667 T/C cg08742575 chr21:47604166 C21orf56 0.36 5.64 0.3 3.65e-8 Testicular germ cell tumor; CRC cis rs7918232 0.556 rs788209 chr10:27434716 G/T cg14240646 chr10:27532245 ACBD5 -0.88 -8.96 -0.44 2.52e-17 Breast cancer; CRC cis rs7591163 1.000 rs940341 chr2:228724726 A/G cg14646075 chr2:228736089 WDR69 -0.43 -5.89 -0.31 9.47e-9 Blood pressure; CRC cis rs9325144 0.600 rs6582630 chr12:38743508 A/G cg13010199 chr12:38710504 ALG10B -0.42 -6.08 -0.32 3.41e-9 Morning vs. evening chronotype; CRC cis rs1552244 0.554 rs6762397 chr3:10007840 C/T cg08888203 chr3:10149979 C3orf24 0.47 7.24 0.37 3.18e-12 Alzheimer's disease; CRC cis rs597539 0.652 rs592697 chr11:68650064 G/A cg06112835 chr11:68658793 MRPL21 0.47 7.57 0.38 3.88e-13 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs1832871 0.672 rs56075516 chr6:158745752 G/A cg07165851 chr6:158734300 TULP4 0.63 7.96 0.4 2.75e-14 Height; CRC cis rs9381040 0.655 rs2294696 chr6:41036988 A/G cg03644281 chr6:41068752 NFYA;LOC221442 0.45 6.53 0.34 2.46e-10 Alzheimer's disease (late onset); CRC cis rs7618501 0.635 rs7635002 chr3:49989155 T/G cg05623727 chr3:50126028 RBM5 0.46 7.54 0.38 4.5e-13 Intelligence (multi-trait analysis); CRC cis rs453301 0.658 rs6986044 chr8:8874786 G/C cg14979609 chr8:8086686 FLJ10661 0.38 6.06 0.32 3.67e-9 Joint mobility (Beighton score); CRC cis rs2841277 0.770 rs10149193 chr14:105403474 C/T cg14403583 chr14:105418241 AHNAK2 -0.33 -5.98 -0.31 5.72e-9 Rheumatoid arthritis; CRC cis rs11098499 0.954 rs12507964 chr4:120413061 T/A cg09307838 chr4:120376055 NA 0.7 10.94 0.52 5.58e-24 Corneal astigmatism; CRC cis rs9368481 0.761 rs9357030 chr6:26985026 G/T cg07220782 chr6:26987966 LOC100270746;C6orf41 -0.43 -6.09 -0.32 3.21e-9 Autism spectrum disorder or schizophrenia; CRC trans rs877282 0.838 rs34912955 chr10:772222 T/C cg22713356 chr15:30763199 NA 1.27 15.87 0.66 1.59e-42 Uric acid levels; CRC cis rs10078 0.571 rs2241597 chr5:480509 A/G cg08916839 chr5:415575 AHRR 0.78 8.2 0.41 5.3e-15 Fat distribution (HIV); CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg04883450 chr5:61699957 DIMT1L 0.5 6.29 0.33 9.82e-10 Thyroid stimulating hormone; CRC cis rs853679 0.517 rs9380056 chr6:28104476 C/T cg15845792 chr6:28175446 NA 1.01 13.54 0.6 1.59e-33 Depression; CRC cis rs360798 0.512 rs17027429 chr2:63079983 C/T cg17519650 chr2:63277830 OTX1 0.43 6.18 0.32 1.94e-9 Coronary artery disease; CRC cis rs34172651 0.517 rs11862923 chr16:24767303 G/T cg00339695 chr16:24857497 SLC5A11 0.44 9.24 0.45 3.21e-18 Intelligence (multi-trait analysis); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg08250099 chr1:6685624 THAP3 0.42 6.1 0.32 2.95e-9 Intelligence (multi-trait analysis); CRC cis rs1178968 1.000 rs6460041 chr7:72757671 A/G cg25889504 chr7:72793014 NA 0.53 5.93 0.31 7.73e-9 Triglyceride levels; CRC cis rs6089584 0.526 rs6089316 chr20:60627552 C/T cg23463467 chr20:60627584 TAF4 0.44 8.31 0.42 2.47e-15 Body mass index; CRC cis rs9611565 0.592 rs80477 chr22:42001183 C/T cg03806693 chr22:41940476 POLR3H 0.71 9.01 0.45 1.67e-17 Vitiligo; CRC cis rs7552404 0.924 rs1146588 chr1:76229787 C/G cg10523679 chr1:76189770 ACADM 0.79 11.89 0.55 2.37e-27 Blood metabolite levels;Acylcarnitine levels; CRC cis rs2836974 0.932 rs6517523 chr21:40557332 T/C cg11644478 chr21:40555479 PSMG1 0.81 12.3 0.56 7.53e-29 Cognitive function; CRC cis rs7618915 0.571 rs1961958 chr3:52585990 A/G cg18404041 chr3:52824283 ITIH1 -0.44 -9.08 -0.45 1.01e-17 Bipolar disorder; CRC cis rs10504229 0.683 rs7838958 chr8:58136968 T/C cg04204079 chr8:58130323 NA -0.45 -5.78 -0.3 1.71e-8 Developmental language disorder (linguistic errors); CRC cis rs9372498 0.536 rs1319988 chr6:118782379 G/A cg15382696 chr6:118971807 C6orf204 0.59 7.5 0.38 6.18e-13 Diastolic blood pressure; CRC cis rs501120 0.584 rs11238890 chr10:44669226 A/T cg09554077 chr10:44749378 NA 0.73 8.07 0.41 1.37e-14 Coronary artery disease;Coronary heart disease; CRC cis rs875971 0.545 rs73142233 chr7:65686280 T/A cg03233332 chr7:66118400 NA -0.42 -5.86 -0.31 1.14e-8 Aortic root size; CRC cis rs6500602 0.563 rs917304 chr16:4440426 C/G cg14951292 chr16:4525986 HMOX2;NMRAL1 0.57 6.89 0.36 2.81e-11 Schizophrenia; CRC cis rs8114671 0.562 rs6060064 chr20:33406339 C/G cg07148914 chr20:33460835 GGT7 -0.37 -5.95 -0.31 6.9e-9 Height; CRC cis rs9611519 1.000 rs6002271 chr22:41566595 C/T cg06634786 chr22:41940651 POLR3H -0.47 -5.99 -0.31 5.64e-9 Neuroticism; CRC cis rs35110281 0.714 rs2282526 chr21:45080552 A/T cg01579765 chr21:45077557 HSF2BP -0.4 -7.8 -0.4 8.11e-14 Mean corpuscular volume; CRC cis rs9368481 0.743 rs9368480 chr6:26955750 A/C cg18278486 chr6:26987575 LOC100270746;C6orf41 0.51 7.88 0.4 4.85e-14 Autism spectrum disorder or schizophrenia; CRC cis rs6701037 0.566 rs13373754 chr1:175139275 C/A cg17845761 chr1:175162550 KIAA0040 0.32 6.77 0.35 6e-11 Alcohol dependence; CRC cis rs4332037 1.000 rs10240470 chr7:1949971 G/T cg23422044 chr7:1970798 MAD1L1 0.55 7.03 0.36 1.17e-11 Bipolar disorder; CRC cis rs1005277 0.602 rs1780141 chr10:38504299 T/C cg00409905 chr10:38381863 ZNF37A -0.62 -10.29 -0.49 1.03e-21 Extrinsic epigenetic age acceleration; CRC cis rs7746199 0.668 rs7749305 chr6:27446566 T/C cg08798685 chr6:27730294 NA -0.74 -6.65 -0.34 1.22e-10 Gait speed in old age;Autism spectrum disorder or schizophrenia; CRC cis rs6951245 0.554 rs11544331 chr7:1131411 C/T cg04025307 chr7:1156635 C7orf50 0.71 8.9 0.44 3.72e-17 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs1950626 0.833 rs12897114 chr14:101395140 A/G cg02351406 chr14:101447389 SNORD114-20;SNORD114-21 0.95 15.97 0.66 6.72e-43 Pelvic organ prolapse (moderate/severe); CRC trans rs116095464 0.558 rs3213838 chr5:223890 G/C cg00938859 chr5:1591904 SDHAP3 0.7 7.63 0.39 2.58e-13 Breast cancer; CRC cis rs4689388 0.926 rs10937719 chr4:6295322 C/G cg25554036 chr4:6271136 WFS1 0.56 8.99 0.44 1.93e-17 Type 2 diabetes and other traits;Type 2 diabetes; CRC cis rs611744 0.647 rs674391 chr8:109242803 A/T cg18478394 chr8:109455254 TTC35 0.38 6.04 0.32 4.09e-9 Dupuytren's disease; CRC cis rs4474465 0.833 rs11606128 chr11:78156960 T/C cg27205649 chr11:78285834 NARS2 -0.44 -5.75 -0.3 2.05e-8 Alzheimer's disease (survival time); CRC cis rs1707322 0.682 rs3014241 chr1:46087879 A/G cg03146154 chr1:46216737 IPP -0.67 -9.45 -0.46 6.45e-19 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs2635047 0.682 rs1980055 chr18:44792636 G/A cg19077165 chr18:44547161 KATNAL2 -0.39 -5.96 -0.31 6.58e-9 Educational attainment; CRC cis rs2996428 0.667 rs11576900 chr1:3770914 A/G cg13057898 chr1:3703894 LRRC47 0.47 6.31 0.33 8.91e-10 Red cell distribution width; CRC cis rs5750830 0.649 rs5750820 chr22:39825322 T/G cg05872129 chr22:39784769 NA -0.61 -11.68 -0.54 1.32e-26 Intelligence (multi-trait analysis); CRC cis rs9611565 0.659 rs169361 chr22:41877989 A/G cg06634786 chr22:41940651 POLR3H 0.62 7.2 0.37 4.11e-12 Vitiligo; CRC cis rs4594175 0.962 rs4254242 chr14:51599184 A/C cg23942311 chr14:51606299 NA 0.66 10.56 0.5 1.22e-22 Cancer; CRC cis rs17253792 0.822 rs45501402 chr14:56140115 C/T cg01858014 chr14:56050164 KTN1 -0.88 -7.22 -0.37 3.55e-12 Putamen volume; CRC cis rs4727027 0.933 rs1044358 chr7:148879951 C/A cg23583168 chr7:148888333 NA -0.93 -16.3 -0.67 3.28e-44 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC cis rs9902453 0.740 rs2254414 chr17:28061130 G/A cg26525008 chr17:28256777 EFCAB5;SSH2 -0.71 -11.94 -0.55 1.47e-27 Coffee consumption (cups per day); CRC cis rs11997175 0.583 rs7464599 chr8:33817572 G/A ch.8.33884649F chr8:33765107 NA 0.43 5.65 0.3 3.52e-8 Body mass index; CRC trans rs10982213 0.830 rs2274163 chr9:117188714 C/T cg25266327 chr19:16435660 KLF2 0.43 6.98 0.36 1.64e-11 Interleukin-6 levels; CRC trans rs7618501 0.699 rs6446187 chr3:49907111 C/A cg21659725 chr3:3221576 CRBN 0.65 10.17 0.49 2.7e-21 Intelligence (multi-trait analysis); CRC cis rs10871290 0.881 rs7498574 chr16:74472661 A/G cg01733217 chr16:74700730 RFWD3 -0.73 -11.76 -0.54 7e-27 Breast cancer; CRC cis rs12928939 0.911 rs77823468 chr16:71828616 C/T cg03805757 chr16:71968109 PKD1L3 -0.47 -6.02 -0.31 4.78e-9 Post bronchodilator FEV1; CRC cis rs7666738 1.000 rs13116475 chr4:99054843 C/T cg17366294 chr4:99064904 C4orf37 -0.43 -6.92 -0.36 2.42e-11 Colonoscopy-negative controls vs population controls; CRC trans rs7647973 0.626 rs12715437 chr3:49751856 T/C cg21665057 chr3:196295764 WDR53;FBXO45 -0.61 -6.73 -0.35 7.76e-11 Menarche (age at onset); CRC cis rs9398803 0.931 rs2045258 chr6:126674354 A/G cg19875578 chr6:126661172 C6orf173 0.41 5.64 0.3 3.69e-8 Male-pattern baldness; CRC cis rs6456156 0.742 rs2022000 chr6:167529611 A/G cg05540913 chr6:167530185 CCR6 -0.41 -7.43 -0.38 9.52e-13 Primary biliary cholangitis; CRC cis rs2836974 0.590 rs11911822 chr21:40607843 C/T cg06238570 chr21:40685208 BRWD1 -0.8 -12.72 -0.57 2e-30 Cognitive function; CRC cis rs9916302 0.904 rs11654018 chr17:37703740 C/T cg03013999 chr17:37608204 MED1 -0.45 -6.99 -0.36 1.55e-11 Glomerular filtration rate (creatinine); CRC cis rs929354 1.000 rs8101 chr7:157061474 A/G cg05182265 chr7:156933206 UBE3C 0.7 13.0 0.58 1.8e-31 Body mass index; CRC cis rs7909074 0.798 rs914699 chr10:45377066 A/C cg05187965 chr10:45406764 TMEM72 -0.36 -8.55 -0.43 4.71e-16 Mean corpuscular volume; CRC cis rs12692738 0.526 rs355864 chr2:165630414 A/T cg03182029 chr2:165697222 COBLL1 0.5 5.86 0.31 1.11e-8 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);Waist-to-hip ratio adjusted for BMI in non-smokers;Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction);Waist-to-hip ratio adjusted for body mass index; CRC cis rs2302190 0.769 rs7215531 chr17:56493374 A/T cg25885038 chr17:56607967 SEPT4 -0.49 -7.52 -0.38 5.09e-13 Vitamin D levels; CRC cis rs6674176 0.628 rs4660758 chr1:44424879 A/C cg12908607 chr1:44402522 ARTN -0.51 -9.08 -0.45 1.02e-17 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Cognitive ability; CRC trans rs11098499 0.954 rs3890049 chr4:120326283 T/A cg25214090 chr10:38739885 LOC399744 0.66 10.51 0.5 1.81e-22 Corneal astigmatism; CRC cis rs12476592 0.602 rs262501 chr2:63858657 A/G cg10828910 chr2:63850056 LOC388955 -0.6 -7.23 -0.37 3.49e-12 Childhood ear infection; CRC cis rs7829975 0.714 rs11777085 chr8:8672429 G/C cg06636001 chr8:8085503 FLJ10661 0.66 10.14 0.49 3.25e-21 Mood instability; CRC cis rs4601821 1.000 rs3897584 chr11:113249725 C/G cg14159747 chr11:113255604 NA -0.47 -8.76 -0.43 1.06e-16 Alcoholic chronic pancreatitis; CRC cis rs7762018 1.000 rs60253563 chr6:170083019 T/C cg17545662 chr6:170176663 C6orf70 0.54 5.98 0.31 5.71e-9 Thiazide-induced adverse metabolic effects in hypertensive patients; CRC cis rs1552244 0.810 rs4019706 chr3:10112862 G/A cg00166722 chr3:10149974 C3orf24 0.66 9.0 0.44 1.85e-17 Alzheimer's disease; CRC cis rs7727544 0.647 rs72793280 chr5:131562900 C/T cg14196790 chr5:131705035 SLC22A5 0.37 6.16 0.32 2.09e-9 Blood metabolite levels; CRC trans rs9329221 0.683 rs3105738 chr8:9889914 A/T cg16141378 chr3:129829833 LOC729375 0.41 6.3 0.33 9.67e-10 Neuroticism; CRC cis rs597539 0.690 rs497149 chr11:68626639 A/T cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.86 14.57 0.63 1.83e-37 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC trans rs1814175 0.791 rs1722011 chr11:49899340 G/C cg15704280 chr7:45808275 SEPT13 -1.02 -20.55 -0.75 5.92e-61 Height; CRC cis rs4664293 0.867 rs7594329 chr2:160572718 A/G cg08347373 chr2:160653686 CD302 -0.47 -7.45 -0.38 8.04e-13 Monocyte percentage of white cells; CRC cis rs3008870 1.000 rs2755244 chr1:67484470 C/T cg08660285 chr1:67390436 MIER1;WDR78 -1.01 -15.28 -0.64 3.2e-40 Lymphocyte percentage of white cells; CRC cis rs902774 0.818 rs17120257 chr12:53303331 T/C cg14581129 chr12:53358946 NA -0.54 -5.95 -0.31 6.77e-9 Prostate cancer; CRC cis rs4713118 0.527 rs35949862 chr6:28115367 A/G cg25164649 chr6:28176230 NA 0.78 9.66 0.47 1.33e-19 Parkinson's disease; CRC cis rs2303759 0.709 rs10422677 chr19:49824290 C/T cg22307029 chr19:49891270 CCDC155 0.67 8.93 0.44 3.04e-17 Multiple sclerosis; CRC cis rs34375054 0.687 rs35540170 chr12:125669122 C/G cg05341575 chr12:125625032 AACS -0.41 -5.81 -0.31 1.44e-8 Post bronchodilator FEV1/FVC ratio; CRC cis rs2949837 0.581 rs2960436 chr7:45977282 G/A cg15898840 chr7:45960834 IGFBP3 0.45 7.4 0.38 1.12e-12 Sitting height ratio; CRC cis rs6968419 0.755 rs3807982 chr7:115898885 T/C cg02561103 chr7:115862891 TES -0.44 -6.59 -0.34 1.74e-10 Intraocular pressure; CRC cis rs3820068 0.581 rs111699992 chr1:15927158 G/A cg27534772 chr1:16042836 PLEKHM2 0.54 10.46 0.5 2.7e-22 Systolic blood pressure; CRC cis rs910316 0.789 rs175444 chr14:75601782 G/C cg03030879 chr14:75389066 RPS6KL1 0.42 6.38 0.33 6.1e-10 Height; CRC cis rs12681287 0.547 rs6985066 chr8:87526439 A/C cg27223183 chr8:87520930 FAM82B -0.55 -7.49 -0.38 6.34e-13 Caudate activity during reward; CRC cis rs2153535 0.580 rs2143355 chr6:8517856 T/A cg21535247 chr6:8435926 SLC35B3 0.49 7.47 0.38 7.33e-13 Motion sickness; CRC cis rs1218582 0.741 rs10908444 chr1:154840287 G/A cg16680214 chr1:154839983 KCNN3 -0.49 -9.9 -0.48 2.18e-20 Prostate cancer; CRC cis rs67478160 0.619 rs11160761 chr14:104254856 A/T cg08213375 chr14:104286397 PPP1R13B 0.65 13.87 0.61 9.58e-35 Schizophrenia; CRC cis rs7959452 0.535 rs4761228 chr12:69682327 G/A cg14784868 chr12:69753453 YEATS4 0.75 12.22 0.56 1.47e-28 Blood protein levels; CRC cis rs751728 0.965 rs4713681 chr6:33754817 T/C cg25922239 chr6:33757077 LEMD2 0.64 10.08 0.49 5.32e-21 Crohn's disease; CRC cis rs4862750 1.000 rs4862751 chr4:187904050 G/A cg03452623 chr4:187889614 NA -0.95 -21.81 -0.77 7.06e-66 Lobe attachment (rater-scored or self-reported); CRC cis rs12780046 0.536 rs10883327 chr10:101084483 C/T cg26459859 chr10:101118273 CNNM1 -0.46 -6.36 -0.33 6.93e-10 Non-glioblastoma glioma; CRC cis rs10924970 0.781 rs10754614 chr1:235493804 G/A cg26050004 chr1:235667680 B3GALNT2 0.39 5.82 0.31 1.37e-8 Asthma; CRC cis rs478304 0.627 rs11604568 chr11:65511336 G/A cg27068330 chr11:65405492 SIPA1 -0.63 -9.46 -0.46 5.9e-19 Acne (severe); CRC cis rs2737618 0.630 rs2821324 chr1:200078006 G/A cg21825944 chr1:200113062 NR5A2 -0.48 -6.86 -0.35 3.4e-11 Uric acid levels; CRC cis rs2404602 0.716 rs12438077 chr15:76863601 T/C cg22467129 chr15:76604101 ETFA -0.39 -6.43 -0.33 4.59e-10 Blood metabolite levels; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg16269447 chr12:9600801 DDX12 0.44 6.14 0.32 2.33e-9 Response to antipsychotic treatment; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg07399355 chr1:155163013 MUC1 0.49 6.27 0.33 1.15e-9 Thyroid stimulating hormone; CRC cis rs6088590 0.603 rs6579186 chr20:33282198 G/C cg08999081 chr20:33150536 PIGU 0.57 10.27 0.49 1.2e-21 Coronary artery disease; CRC cis rs6088580 0.609 rs6058029 chr20:32969643 T/C cg08999081 chr20:33150536 PIGU -0.6 -11.21 -0.53 6.38e-25 Glomerular filtration rate (creatinine); CRC cis rs7937682 0.681 rs7107378 chr11:111401840 C/A cg09085632 chr11:111637200 PPP2R1B 0.58 7.83 0.4 6.83e-14 Primary sclerosing cholangitis; CRC cis rs8105895 0.935 rs7250905 chr19:22250743 C/T cg02657401 chr19:22469223 NA -0.34 -5.65 -0.3 3.56e-8 Body mass index (change over time); CRC cis rs2806561 0.704 rs663942 chr1:23522476 G/A cg12483005 chr1:23474871 LUZP1 0.49 6.99 0.36 1.5e-11 Height; CRC cis rs2580764 0.540 rs2920893 chr2:55270629 C/T cg09592903 chr2:55203963 RTN4 0.71 11.55 0.54 4.04e-26 Mean platelet volume; CRC cis rs7927592 0.731 rs10896350 chr11:68386373 A/C cg01657329 chr11:68192670 LRP5 -0.54 -8.88 -0.44 4.51e-17 Total body bone mineral density; CRC cis rs11098499 0.863 rs3822194 chr4:120471648 A/G cg24375607 chr4:120327624 NA 0.48 7.49 0.38 6.38e-13 Corneal astigmatism; CRC cis rs910316 1.000 rs13099 chr14:75599155 G/A cg11812906 chr14:75593930 NEK9 -0.59 -9.23 -0.45 3.38e-18 Height; CRC cis rs4666002 0.564 rs13030345 chr2:28003174 A/C cg27432699 chr2:27873401 GPN1 -0.58 -6.81 -0.35 4.54e-11 Phospholipid levels (plasma); CRC trans rs7937682 0.889 rs7926485 chr11:111536670 G/A cg18187862 chr3:45730750 SACM1L 0.46 6.74 0.35 7.28e-11 Primary sclerosing cholangitis; CRC cis rs9399135 0.935 rs4445070 chr6:135309212 C/T cg24558204 chr6:135376177 HBS1L 0.5 7.77 0.39 9.86e-14 Red blood cell count; CRC cis rs875971 0.893 rs62465470 chr7:65601218 T/C cg18252515 chr7:66147081 NA 0.41 5.89 0.31 9.34e-9 Aortic root size; CRC cis rs10256972 0.591 rs6968988 chr7:1169619 A/G cg04025307 chr7:1156635 C7orf50 0.72 12.11 0.56 3.52e-28 Longevity;Endometriosis; CRC cis rs2243480 1.000 rs7804223 chr7:65664559 T/G cg25985355 chr7:65971099 NA 0.53 5.93 0.31 7.52e-9 Diabetic kidney disease; CRC cis rs514406 0.505 rs269292 chr1:53187911 T/C cg08859206 chr1:53392774 SCP2 -0.4 -6.13 -0.32 2.45e-9 Monocyte count; CRC cis rs76878669 0.538 rs4930360 chr11:66143247 T/A cg24851651 chr11:66362959 CCS -0.39 -6.69 -0.35 9.43e-11 Educational attainment (years of education); CRC cis rs6997458 0.712 rs9987281 chr8:86348830 A/T cg21346043 chr8:86351067 CA3 0.28 6.17 0.32 1.96e-9 Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; CRC cis rs3736485 0.934 rs114641722 chr15:51863572 G/A cg08986416 chr15:51914746 DMXL2 -0.45 -6.56 -0.34 2.12e-10 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs7246967 0.673 rs34671960 chr19:22948693 G/A cg08271804 chr19:22816896 ZNF492 0.38 5.89 0.31 9.46e-9 Bronchopulmonary dysplasia; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg03345567 chr19:50321589 MED25 0.45 5.98 0.31 5.87e-9 Anxiety disorder; CRC cis rs936229 0.749 rs8031937 chr15:75181121 A/G cg10253484 chr15:75165896 SCAMP2 -0.46 -6.81 -0.35 4.71e-11 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); CRC cis rs11764590 0.543 rs55893771 chr7:2096255 C/T cg24505167 chr7:1915268 MAD1L1 -0.42 -5.81 -0.3 1.49e-8 Neuroticism; CRC cis rs6502050 0.667 rs9892469 chr17:80093657 T/C cg19223190 chr17:80058835 NA 0.4 6.5 0.34 3.06e-10 Life satisfaction; CRC cis rs651907 0.514 rs11706494 chr3:101509475 A/T cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.59 7.84 0.4 6.37e-14 Colorectal cancer; CRC trans rs7819412 0.775 rs2001329 chr8:10986859 C/T cg06636001 chr8:8085503 FLJ10661 -0.55 -7.94 -0.4 3.26e-14 Triglycerides; CRC cis rs7552404 0.727 rs7547508 chr1:76327958 A/G cg10523679 chr1:76189770 ACADM -0.65 -8.5 -0.42 6.68e-16 Blood metabolite levels;Acylcarnitine levels; CRC cis rs2072499 0.966 rs2842857 chr1:156168736 T/C cg24450063 chr1:156163899 SLC25A44 1.15 28.33 0.84 3e-90 Testicular germ cell tumor; CRC cis rs56235845 0.694 rs4532376 chr5:176774403 G/A cg17261708 chr5:176794207 RGS14 0.49 8.12 0.41 9.63e-15 Hemoglobin concentration;Hematocrit; CRC cis rs6502050 0.799 rs4789681 chr17:80100546 G/A cg22110888 chr17:80059540 CCDC57 0.4 6.44 0.33 4.17e-10 Life satisfaction; CRC cis rs4660214 0.724 rs3931300 chr1:39660847 A/G cg11070191 chr1:39582205 MACF1 0.36 5.66 0.3 3.22e-8 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs600626 0.529 rs11236525 chr11:75467545 C/G cg24262691 chr11:75473276 NA 0.51 7.39 0.38 1.21e-12 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CRC cis rs8060686 0.920 rs112894876 chr16:67812039 G/C cg19582491 chr16:67682965 RLTPR -0.57 -6.53 -0.34 2.56e-10 HDL cholesterol;Metabolic syndrome; CRC cis rs751728 0.687 rs9357164 chr6:33761021 T/C cg25922239 chr6:33757077 LEMD2 0.46 6.8 0.35 4.81e-11 Crohn's disease; CRC cis rs17376456 0.825 rs56108532 chr5:93276342 C/T cg09848695 chr5:92956644 FAM172A;MIR2277 0.66 5.99 0.31 5.47e-9 Diabetic retinopathy; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg13558695 chr2:25500125 DNMT3A 0.24 6.9 0.36 2.72e-11 Liver disease severity in Alagille syndrome; CRC cis rs2836974 0.644 rs1882779 chr21:40690938 T/C cg11890956 chr21:40555474 PSMG1 -0.81 -12.66 -0.57 3.41e-30 Cognitive function; CRC cis rs898097 0.812 rs72859941 chr17:80837459 G/A cg19046167 chr17:80928561 B3GNTL1 -0.43 -6.71 -0.35 8.57e-11 Breast cancer; CRC cis rs8062405 1.000 rs55719896 chr16:28846866 G/A cg16576597 chr16:28551801 NUPR1 0.48 6.9 0.36 2.65e-11 Cognitive ability (multi-trait analysis);Cognitive ability; CRC cis rs7727544 0.660 rs272886 chr5:131665840 T/C cg21138405 chr5:131827807 IRF1 -0.31 -5.7 -0.3 2.63e-8 Blood metabolite levels; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg26221971 chr16:57318603 PLLP 0.42 6.03 0.32 4.38e-9 Response to antipsychotic treatment; CRC cis rs2276314 0.857 rs28431958 chr18:33578401 T/G cg19628046 chr18:33552617 C18orf21 0.56 7.39 0.38 1.22e-12 Endometriosis;Drug-induced torsades de pointes; CRC cis rs9916302 0.904 rs6503503 chr17:37514373 G/A cg03013999 chr17:37608204 MED1 -0.46 -6.85 -0.35 3.7e-11 Glomerular filtration rate (creatinine); CRC cis rs28386778 0.863 rs6919 chr17:61909485 A/T cg22520471 chr17:61851767 DDX42;CCDC47 -0.75 -11.92 -0.55 1.87e-27 Prudent dietary pattern; CRC cis rs853679 0.517 rs9368556 chr6:28131153 T/C cg06470822 chr6:28175283 NA 1.03 13.59 0.6 1.04e-33 Depression; CRC cis rs9894429 0.646 rs7406522 chr17:79615396 G/T cg09655341 chr17:79618100 PDE6G -0.35 -6.07 -0.32 3.46e-9 Eye color traits; CRC trans rs1455244 0.700 rs7229302 chr18:11508904 G/T cg08762750 chr15:91497995 RCCD1 0.43 6.68 0.35 1e-10 Schizophrenia; CRC cis rs3815700 1.000 rs7248845 chr19:33096718 T/C cg02997394 chr19:33096574 ANKRD27 0.76 9.0 0.44 1.86e-17 Eosinophilic esophagitis; CRC cis rs7219014 1 rs7219014 chr17:37624790 A/G cg07936489 chr17:37558343 FBXL20 -0.82 -12.27 -0.56 9.41e-29 Urinary metabolites; CRC cis rs977987 0.806 rs11862095 chr16:75385418 T/A cg03315344 chr16:75512273 CHST6 0.5 8.43 0.42 1.07e-15 Dupuytren's disease; CRC cis rs28386778 0.897 rs2584639 chr17:61863732 C/T cg06873352 chr17:61820015 STRADA 0.77 14.5 0.62 3.51e-37 Prudent dietary pattern; CRC cis rs7412746 0.611 rs3768018 chr1:150723747 T/C cg18016565 chr1:150552671 MCL1 0.43 5.85 0.31 1.16e-8 Melanoma; CRC trans rs925098 0.577 rs2724470 chr4:17996046 A/G cg07360250 chr5:176830358 F12 -0.4 -6.02 -0.31 4.76e-9 Birth weight;Height; CRC cis rs4234798 1.000 rs4689088 chr4:7222253 G/A cg18431297 chr4:7219810 SORCS2 0.6 10.56 0.5 1.18e-22 Insulin-like growth factors; CRC cis rs7044106 0.791 rs10985000 chr9:123484115 A/G cg14255062 chr9:123606675 PSMD5;LOC253039 0.47 7.08 0.36 8.96e-12 Hip circumference adjusted for BMI; CRC cis rs3617 0.625 rs7620690 chr3:52891707 A/G cg11645453 chr3:52864694 ITIH4 -0.46 -9.19 -0.45 4.7e-18 Red blood cell count;Autism spectrum disorder or schizophrenia; CRC cis rs9811920 0.666 rs793456 chr3:99525631 G/A cg07805332 chr3:99536008 MIR548G;C3orf26 0.4 6.13 0.32 2.57e-9 Axial length; CRC cis rs2290159 0.800 rs2290162 chr3:12647457 A/G cg23032965 chr3:12705835 RAF1 0.47 6.31 0.33 8.78e-10 Cholesterol, total; CRC cis rs12476592 0.543 rs12105140 chr2:63797218 A/G cg10828910 chr2:63850056 LOC388955 0.47 5.79 0.3 1.62e-8 Childhood ear infection; CRC cis rs3106136 0.967 rs2306802 chr4:95186055 A/G cg11021082 chr4:95130006 SMARCAD1 -0.45 -6.5 -0.34 2.96e-10 Capecitabine sensitivity; CRC trans rs877282 1.000 rs877281 chr10:771557 T/G cg22713356 chr15:30763199 NA 1.27 15.87 0.66 1.59e-42 Uric acid levels; CRC cis rs73001065 0.536 rs10408596 chr19:19512657 A/T cg03709012 chr19:19516395 GATAD2A 0.83 6.98 0.36 1.64e-11 LDL cholesterol; CRC cis rs6546324 0.625 rs1023691 chr2:67868794 G/A cg15745817 chr2:67799979 NA -0.55 -9.54 -0.47 3.34e-19 Endometriosis; CRC cis rs3806843 0.576 rs246003 chr5:140340865 C/G cg19875535 chr5:140030758 IK 0.4 6.12 0.32 2.64e-9 Depressive symptoms (multi-trait analysis); CRC cis rs1046896 0.627 rs7225515 chr17:80795783 C/T cg08200770 chr17:80723486 TBCD -0.51 -7.78 -0.39 9.74e-14 Glycated hemoglobin levels; CRC cis rs9467773 0.526 rs10946817 chr6:26364056 C/T cg09904177 chr6:26538194 HMGN4 -0.44 -6.09 -0.32 3.12e-9 Intelligence (multi-trait analysis); CRC cis rs873946 0.648 rs12766050 chr10:134549108 G/A cg18305652 chr10:134549665 INPP5A 0.48 6.34 0.33 7.51e-10 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CRC cis rs9868809 0.881 rs57334642 chr3:48666795 C/T cg00383909 chr3:49044727 WDR6 0.77 7.67 0.39 1.93e-13 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; CRC cis rs753778 1.000 rs4961257 chr8:142232704 A/G cg23750338 chr8:142222470 SLC45A4 -0.37 -5.69 -0.3 2.78e-8 Reticulocyte fraction of red cells;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; CRC cis rs6714710 0.603 rs13008968 chr2:98435982 C/T cg26665480 chr2:98280029 ACTR1B 0.52 7.23 0.37 3.3e-12 Posterior cortical atrophy and Alzheimer's disease; CRC cis rs8031584 0.678 rs798086 chr15:31129211 C/G cg08109568 chr15:31115862 NA 0.65 9.94 0.48 1.6e-20 Huntington's disease progression; CRC cis rs2290159 0.800 rs9809947 chr3:12655944 T/C cg23032965 chr3:12705835 RAF1 0.47 6.31 0.33 8.78e-10 Cholesterol, total; CRC cis rs9522267 0.535 rs9515453 chr13:112234612 T/C cg14352298 chr13:112236639 NA 0.29 6.67 0.35 1.06e-10 Hepatitis; CRC cis rs7727544 0.735 rs274559 chr5:131720070 A/G cg24060327 chr5:131705240 SLC22A5 0.36 5.91 0.31 8.67e-9 Blood metabolite levels; CRC cis rs17539620 0.534 rs76931320 chr6:154833508 G/A cg20019720 chr6:154832845 CNKSR3 0.5 8.08 0.41 1.2e-14 Lipoprotein (a) levels; CRC cis rs2795502 0.873 rs3121282 chr10:43423626 T/A cg27426351 chr10:43362370 NA 0.54 6.64 0.34 1.33e-10 Blood protein levels; CRC cis rs7666738 0.962 rs17027204 chr4:98997049 G/A cg17366294 chr4:99064904 C4orf37 0.46 7.45 0.38 8.08e-13 Colonoscopy-negative controls vs population controls; CRC cis rs951366 0.585 rs72750964 chr1:205675240 C/T cg14159672 chr1:205819179 PM20D1 0.71 9.94 0.48 1.53e-20 Menarche (age at onset); CRC cis rs4423214 0.535 rs1540129 chr11:71129523 C/G cg05163923 chr11:71159392 DHCR7 0.56 7.56 0.38 4.11e-13 Vitamin D levels; CRC cis rs8072100 0.811 rs9889709 chr17:45445229 C/T cg08085267 chr17:45401833 C17orf57 -0.68 -11.54 -0.54 4.28e-26 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs56176327 0.600 rs7628207 chr3:49754970 T/C cg03060546 chr3:49711283 APEH 0.66 8.29 0.42 3e-15 Intelligence (multi-trait analysis); CRC cis rs11758351 0.660 rs55643278 chr6:26222888 C/A cg10723962 chr6:26240782 HIST1H4F -0.38 -6.07 -0.32 3.49e-9 Gout;Renal underexcretion gout; CRC cis rs28386778 0.897 rs2727333 chr17:61876023 G/A cg06873352 chr17:61820015 STRADA 0.77 14.5 0.62 3.45e-37 Prudent dietary pattern; CRC cis rs1401999 0.932 rs4148557 chr3:183733784 A/G cg05044414 chr3:183734942 ABCC5 0.43 7.36 0.38 1.48e-12 Anterior chamber depth; CRC cis rs7927771 0.864 rs60075622 chr11:47449101 T/G cg18512352 chr11:47633146 NA -0.39 -7.66 -0.39 2.06e-13 Subjective well-being; CRC cis rs2019137 0.539 rs11123170 chr2:113978940 C/G cg17445212 chr2:113993313 PAX8;LOC440839;LOC654433 0.48 7.22 0.37 3.66e-12 Lymphocyte counts; CRC cis rs10751667 0.714 rs7933889 chr11:972270 C/T cg06064525 chr11:970664 AP2A2 -0.31 -6.18 -0.32 1.89e-9 Alzheimer's disease (late onset); CRC cis rs4845875 0.626 rs6697244 chr1:11838848 G/T cg02448276 chr1:11845238 NA 0.36 5.61 0.3 4.38e-8 Midregional pro atrial natriuretic peptide levels; CRC trans rs916888 0.773 rs199447 chr17:44812188 C/T cg23590916 chr17:43697445 MGC57346 0.7 7.18 0.37 4.6e-12 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs769267 0.965 rs8101938 chr19:19390497 G/A cg20644253 chr19:19431407 KIAA0892;SF4 0.43 5.97 0.31 6e-9 Tonsillectomy; CRC trans rs4263408 0.934 rs9683743 chr4:39703194 A/C cg02839273 chr15:85525387 PDE8A -0.41 -6.14 -0.32 2.34e-9 Plasma amyloid beta peptide concentrations (ABx-40); CRC cis rs12220238 1.000 rs8255 chr10:75879750 G/A cg19889307 chr10:75911429 ADK;AP3M1 0.64 6.44 0.33 4.13e-10 Soluble interleukin-2 receptor subunit alpha; CRC cis rs2153535 0.580 rs9379215 chr6:8481225 G/A cg21535247 chr6:8435926 SLC35B3 0.5 7.54 0.38 4.72e-13 Motion sickness; CRC cis rs28386778 1.000 rs3020613 chr17:61955983 A/G cg25654072 chr17:61904446 PSMC5;FTSJ3 0.7 10.75 0.51 2.57e-23 Prudent dietary pattern; CRC cis rs7107174 1.000 rs7128666 chr11:78102363 A/T cg02023728 chr11:77925099 USP35 0.47 7.25 0.37 2.92e-12 Testicular germ cell tumor; CRC cis rs11098499 0.954 rs6846442 chr4:120326323 G/A cg24375607 chr4:120327624 NA 0.51 7.98 0.4 2.49e-14 Corneal astigmatism; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg26608221 chr2:74692293 MOGS -0.43 -6.52 -0.34 2.66e-10 Myopia (pathological); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg18760119 chr6:127587834 RNF146 0.43 6.11 0.32 2.8e-9 Response to antipsychotic treatment; CRC cis rs13191362 1.000 rs67025553 chr6:163011552 C/T cg06582575 chr6:163149167 PACRG;PARK2 0.76 10.41 0.5 4.01e-22 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs67478160 0.572 rs8015603 chr14:104293678 C/G cg08213375 chr14:104286397 PPP1R13B 0.65 13.31 0.59 1.24e-32 Schizophrenia; CRC cis rs977987 0.806 rs12051326 chr16:75437887 G/A cg03315344 chr16:75512273 CHST6 0.54 9.09 0.45 9.68e-18 Dupuytren's disease; CRC cis rs6547741 0.752 rs7562863 chr2:27892694 T/A cg27432699 chr2:27873401 GPN1 -0.82 -15.72 -0.65 6.47e-42 Oral cavity cancer; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg13056269 chr2:136633607 MCM6 0.46 6.06 0.32 3.69e-9 Anxiety disorder; CRC cis rs3106136 1.000 rs3106136 chr4:95153349 T/C cg11021082 chr4:95130006 SMARCAD1 -0.47 -7.36 -0.38 1.44e-12 Capecitabine sensitivity; CRC cis rs28386778 0.562 rs721575 chr17:61782920 A/G cg06873352 chr17:61820015 STRADA -0.68 -12.35 -0.56 4.94e-29 Prudent dietary pattern; CRC cis rs9409565 0.762 rs60964095 chr9:97175774 G/T cg04523069 chr9:97136363 HIATL1 0.36 5.62 0.3 4.05e-8 Colorectal cancer (alcohol consumption interaction); CRC cis rs6570726 0.791 rs6912079 chr6:145894949 G/A cg05347473 chr6:146136440 FBXO30 0.4 6.1 0.32 3.05e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs896854 1.000 rs13255935 chr8:95965685 C/A cg13393036 chr8:95962371 TP53INP1 -0.52 -8.74 -0.43 1.2e-16 Type 2 diabetes; CRC cis rs3736485 0.868 rs8023455 chr15:51936510 G/A cg08986416 chr15:51914746 DMXL2 -0.46 -6.5 -0.34 2.92e-10 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs2153535 0.580 rs7769020 chr6:8457724 G/A cg07606381 chr6:8435919 SLC35B3 0.69 11.15 0.52 1.04e-24 Motion sickness; CRC cis rs6860806 0.507 rs272868 chr5:131680751 C/G cg20512303 chr5:131592959 PDLIM4 0.38 6.59 0.34 1.74e-10 Breast cancer; CRC cis rs9443189 0.570 rs72888705 chr6:76403114 A/G cg01950844 chr6:76311363 SENP6 0.74 9.84 0.48 3.35e-20 Prostate cancer; CRC cis rs7615952 0.641 rs6438951 chr3:125696999 A/G cg02807482 chr3:125708958 NA -0.46 -6.05 -0.32 3.94e-9 Blood pressure (smoking interaction); CRC cis rs7945718 0.967 rs10765990 chr11:12769444 G/A cg25843174 chr11:12811716 TEAD1 0.48 9.09 0.45 9.5e-18 Educational attainment (years of education); CRC cis rs896854 0.684 rs10099941 chr8:95987008 C/T cg16049864 chr8:95962084 TP53INP1 -0.64 -11.74 -0.54 7.81e-27 Type 2 diabetes; CRC cis rs6968419 0.747 rs6957561 chr7:115888339 G/A cg02561103 chr7:115862891 TES -0.42 -6.28 -0.33 1.06e-9 Intraocular pressure; CRC trans rs4452313 0.884 rs7648912 chr3:17076560 C/G cg24680248 chr19:8426630 NA 0.4 6.39 0.33 5.52e-10 Rheumatoid arthritis; CRC trans rs66887589 0.934 rs12648182 chr4:120503891 T/A cg25214090 chr10:38739885 LOC399744 -0.43 -6.65 -0.34 1.2e-10 Diastolic blood pressure; CRC cis rs875971 0.789 rs10260426 chr7:65736042 G/T cg12463550 chr7:65579703 CRCP -0.5 -6.72 -0.35 8.01e-11 Aortic root size; CRC trans rs561341 0.883 rs886224 chr17:30229902 T/C cg27661571 chr11:113659931 NA -0.67 -7.54 -0.38 4.55e-13 Hip circumference adjusted for BMI; CRC cis rs7769051 0.615 rs12209144 chr6:133191064 A/T cg07930552 chr6:133119739 C6orf192 0.59 6.66 0.34 1.12e-10 Type 2 diabetes nephropathy; CRC cis rs12042938 0.600 rs4658880 chr1:231764621 G/C cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX 0.47 6.28 0.33 1.06e-9 Neuranatomic and neurocognitive phenotypes; CRC cis rs2762353 0.595 rs12207313 chr6:25741027 G/C cg07061783 chr6:25882402 NA 0.5 6.44 0.33 4.23e-10 Blood metabolite levels; CRC cis rs490234 0.702 rs12553311 chr9:128398996 T/C cg14078157 chr9:128172775 NA -0.4 -6.62 -0.34 1.44e-10 Mean arterial pressure; CRC cis rs2243480 1.000 rs781150 chr7:65480973 C/T cg12463550 chr7:65579703 CRCP 0.72 6.52 0.34 2.59e-10 Diabetic kidney disease; CRC cis rs763014 0.966 rs7185390 chr16:666382 A/G cg00802000 chr16:706648 WDR90 -0.44 -6.36 -0.33 6.84e-10 Height; CRC cis rs6912958 0.703 rs9362427 chr6:88097634 G/T cg08069147 chr6:88032118 GJB7;C6orf162 0.73 11.56 0.54 3.61e-26 Monocyte percentage of white cells; CRC cis rs7589728 0.563 rs4972044 chr2:88466196 T/C cg18490616 chr2:88469792 THNSL2 0.58 5.85 0.31 1.22e-8 Plasma clusterin levels; CRC cis rs55665837 1.000 rs10832278 chr11:14496619 G/A cg19336497 chr11:14380999 RRAS2 -0.38 -6.45 -0.34 3.9e-10 Vitamin D levels; CRC cis rs13118159 0.550 rs2336081 chr4:1350322 A/G cg19318889 chr4:1322082 MAEA -0.69 -10.25 -0.49 1.36e-21 Longevity; CRC cis rs1552244 0.882 rs112621205 chr3:10017916 G/A cg10729496 chr3:10149963 C3orf24 0.48 6.25 0.33 1.25e-9 Alzheimer's disease; CRC cis rs7725052 0.575 rs4957303 chr5:40466277 T/C cg09067459 chr5:40385259 NA 0.39 6.4 0.33 5.31e-10 Pediatric autoimmune diseases; CRC cis rs270601 0.690 rs162907 chr5:131580152 A/G cg18301423 chr5:131593218 PDLIM4 -0.47 -8.27 -0.41 3.3e-15 Acylcarnitine levels; CRC cis rs7811142 0.945 rs6955362 chr7:100056166 C/T cg00814883 chr7:100076585 TSC22D4 -0.75 -9.44 -0.46 6.97e-19 Platelet count; CRC cis rs9611565 0.659 rs9607813 chr22:41941479 G/A cg03806693 chr22:41940476 POLR3H -1.13 -15.31 -0.65 2.48e-40 Vitiligo; CRC cis rs2249694 1.000 rs2515644 chr10:135353079 A/C cg16964102 chr10:135390573 NA -0.38 -6.21 -0.32 1.57e-9 Obesity-related traits; CRC cis rs10504229 0.683 rs6982990 chr8:58115275 C/T cg24829409 chr8:58192753 C8orf71 0.51 7.81 0.4 7.99e-14 Developmental language disorder (linguistic errors); CRC cis rs1046896 1.000 rs9909940 chr17:80689036 C/T cg02398342 chr17:80708632 TBCD;FN3K 0.35 5.65 0.3 3.54e-8 Glycated hemoglobin levels; CRC cis rs148803332 1 rs148803332 chr17:65958250 CAAAAGAAA/C cg12091567 chr17:66097778 LOC651250 0.64 8.02 0.4 1.88e-14 Eosinophil percentage of white cells;Neutrophil percentage of granulocytes; CRC trans rs2303319 0.504 rs62189054 chr2:162624654 C/G cg04551154 chr10:95462393 C10orf4 -0.74 -6.34 -0.33 7.76e-10 Cognitive function; CRC cis rs765787 0.530 rs4774550 chr15:45542312 C/T cg24006582 chr15:45444508 DUOX1 -0.55 -8.3 -0.42 2.72e-15 Uric acid levels; CRC cis rs172166 0.516 rs1225710 chr6:28100640 C/T cg23161317 chr6:28129485 ZNF389 -0.39 -5.89 -0.31 9.52e-9 Cardiac Troponin-T levels; CRC cis rs4363385 0.818 rs3820141 chr1:153004778 C/T cg25856811 chr1:152973957 SPRR3 -0.25 -6.93 -0.36 2.19e-11 Inflammatory skin disease; CRC cis rs2046867 0.862 rs62251657 chr3:72832076 C/T cg25664220 chr3:72788482 NA -0.45 -6.28 -0.33 1.07e-9 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; CRC cis rs728616 0.867 rs12414877 chr10:81780708 A/G cg05935833 chr10:81318306 SFTPA2 -0.74 -7.92 -0.4 3.58e-14 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs926938 0.783 rs2144428 chr1:115269211 G/A cg12756093 chr1:115239321 AMPD1 -0.7 -10.94 -0.52 5.89e-24 Autism; CRC cis rs4750440 0.576 rs2447011 chr10:14032199 C/T cg04819048 chr10:14014548 FRMD4A 0.36 6.0 0.31 5.31e-9 Adiponectin levels; CRC cis rs6951245 0.744 rs10265736 chr7:1172465 C/T cg26224354 chr7:1096374 C7orf50;GPR146 -0.81 -10.83 -0.51 1.37e-23 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs4563143 0.514 rs73030738 chr19:29312328 G/A cg03161606 chr19:29218774 NA 0.52 6.07 0.32 3.52e-9 Methadone dose in opioid dependence; CRC cis rs10504229 0.639 rs55687236 chr8:58105856 C/T cg20607798 chr8:58055168 NA 0.58 6.58 0.34 1.87e-10 Developmental language disorder (linguistic errors); CRC trans rs2303319 0.504 rs58622044 chr2:162596287 A/G cg16699849 chr7:98923489 ARPC1A -0.68 -6.2 -0.32 1.66e-9 Cognitive function; CRC cis rs11583043 1.000 rs11584222 chr1:101480110 G/C cg16556008 chr1:101360663 SLC30A7;EXTL2 0.45 5.68 0.3 3.01e-8 Ulcerative colitis;Inflammatory bowel disease; CRC cis rs216303 0.642 rs216318 chr12:6139261 A/C cg19878637 chr12:6148451 VWF -0.59 -6.55 -0.34 2.24e-10 Low vWF levels; CRC cis rs4363385 0.693 rs418550 chr1:153048045 A/T cg25856811 chr1:152973957 SPRR3 -0.23 -6.25 -0.33 1.3e-9 Inflammatory skin disease; CRC cis rs853679 0.628 rs9368560 chr6:28159960 T/C cg12273811 chr6:28175739 NA 0.73 9.97 0.48 1.29e-20 Depression; CRC cis rs3741151 0.773 rs73542960 chr11:73115946 T/C cg17517138 chr11:73019481 ARHGEF17 0.9 7.49 0.38 6.41e-13 GIP levels in response to oral glucose tolerance test (120 minutes); CRC cis rs10193935 0.901 rs222486 chr2:42649664 C/T cg27598129 chr2:42591480 NA -0.62 -7.2 -0.37 4.17e-12 Colonoscopy-negative controls vs population controls; CRC cis rs2050392 0.624 rs303450 chr10:30725337 C/A cg25182066 chr10:30743637 MAP3K8 -0.45 -5.99 -0.31 5.55e-9 Inflammatory bowel disease; CRC cis rs1862618 0.715 rs6866779 chr5:56090000 G/A cg22800045 chr5:56110881 MAP3K1 0.56 6.06 0.32 3.78e-9 Initial pursuit acceleration; CRC cis rs4664293 0.546 rs12469866 chr2:160622630 G/C cg08347373 chr2:160653686 CD302 0.35 5.8 0.3 1.56e-8 Monocyte percentage of white cells; CRC cis rs798554 0.757 rs1182171 chr7:2878510 A/G cg14895029 chr7:2775587 GNA12 -0.41 -6.07 -0.32 3.53e-9 Height; CRC cis rs7493 0.516 rs13233527 chr7:95068795 T/C cg04155289 chr7:94953770 PON1 -0.45 -6.04 -0.32 4.15e-9 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs9916302 0.605 rs12938099 chr17:37612910 T/G cg20243544 chr17:37824526 PNMT 0.47 5.6 0.3 4.49e-8 Glomerular filtration rate (creatinine); CRC cis rs2576037 0.583 rs10070 chr18:44388899 G/A cg23996704 chr18:44553084 KATNAL2 -0.32 -6.36 -0.33 6.83e-10 Personality dimensions; CRC cis rs72781680 0.821 rs72796401 chr2:24180078 T/A cg08917208 chr2:24149416 ATAD2B 0.57 6.82 0.35 4.39e-11 Lymphocyte counts; CRC cis rs9649465 0.934 rs34030532 chr7:123274992 A/G cg03229431 chr7:123269106 ASB15 -0.42 -6.35 -0.33 7.06e-10 Migraine; CRC trans rs1814175 0.817 rs2866545 chr11:49630824 A/C cg11707556 chr5:10655725 ANKRD33B -0.43 -8.12 -0.41 9.45e-15 Height; CRC cis rs1577917 1.000 rs12209127 chr6:86724427 A/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.52 -6.53 -0.34 2.57e-10 Response to antipsychotic treatment; CRC cis rs79349575 0.749 rs2546491 chr17:46977916 A/G cg22482690 chr17:47019901 SNF8 0.49 8.2 0.41 5.55e-15 Type 2 diabetes; CRC cis rs58688157 0.705 rs12421646 chr11:578844 C/G cg07212818 chr11:638076 DRD4 -0.48 -6.15 -0.32 2.18e-9 Systemic lupus erythematosus; CRC cis rs1799949 0.965 rs2236762 chr17:41226675 A/T cg23758822 chr17:41437982 NA 0.86 15.87 0.66 1.68e-42 Menopause (age at onset); CRC cis rs2271001 0.955 rs12273085 chr11:19138511 G/C cg00161556 chr11:19138045 ZDHHC13 0.35 5.67 0.3 3.16e-8 Gut microbiome composition (winter); CRC cis rs67478160 0.619 rs10083367 chr14:104314183 C/G cg01849466 chr14:104193079 ZFYVE21 0.47 8.17 0.41 6.84e-15 Schizophrenia; CRC trans rs561341 1.000 rs2470267 chr17:30274132 G/A cg27661571 chr11:113659931 NA -0.71 -8.71 -0.43 1.53e-16 Hip circumference adjusted for BMI; CRC cis rs9322817 0.607 rs9404572 chr6:105149439 T/C cg02098413 chr6:105308735 HACE1 -0.43 -8.4 -0.42 1.36e-15 Thyroid stimulating hormone; CRC cis rs2952156 0.959 rs1495102 chr17:37832093 T/C cg20243544 chr17:37824526 PNMT 0.55 8.43 0.42 1.08e-15 Asthma; CRC cis rs17270561 1.000 rs17270561 chr6:25820439 A/C cg16482183 chr6:26056742 HIST1H1C -0.91 -10.28 -0.49 1.15e-21 Iron status biomarkers; CRC cis rs832540 0.656 rs832567 chr5:56152416 C/A cg12311346 chr5:56204834 C5orf35 -0.53 -7.85 -0.4 5.77e-14 Coronary artery disease; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg00230302 chr9:21802598 MTAP 0.44 6.31 0.33 9.23e-10 Response to antipsychotic treatment; CRC trans rs916888 0.647 rs199449 chr17:44808902 G/A cg10053473 chr17:62856997 LRRC37A3 -0.63 -8.7 -0.43 1.56e-16 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs1538970 0.962 rs9429076 chr1:45819489 A/G cg05343316 chr1:45956843 TESK2 0.62 8.38 0.42 1.59e-15 Platelet count; CRC cis rs425277 0.585 rs2222217 chr1:2063164 G/A cg04315214 chr1:2043799 PRKCZ 0.51 8.87 0.44 4.59e-17 Height; CRC cis rs2839186 0.872 rs2250213 chr21:47674275 G/A cg20399509 chr21:47717575 C21orf57 -0.34 -5.67 -0.3 3.06e-8 Testicular germ cell tumor; CRC cis rs853679 0.569 rs9348798 chr6:28143011 G/A cg12273811 chr6:28175739 NA 0.72 9.03 0.45 1.47e-17 Depression; CRC cis rs1129187 0.755 rs13215983 chr6:42924193 C/T cg02359409 chr6:42947317 PEX6 -0.69 -11.41 -0.53 1.28e-25 Alzheimer's disease in APOE e4+ carriers; CRC cis rs4332037 0.539 rs55993248 chr7:2071132 A/G cg23378565 chr7:2036160 MAD1L1 -0.45 -6.37 -0.33 6.24e-10 Bipolar disorder; CRC cis rs10504229 0.683 rs73605816 chr8:58117167 T/C cg02725872 chr8:58115012 NA -0.64 -11.55 -0.54 3.85e-26 Developmental language disorder (linguistic errors); CRC trans rs9693857 0.520 rs11249927 chr8:9361606 C/T cg06636001 chr8:8085503 FLJ10661 0.47 6.15 0.32 2.19e-9 Systolic blood pressure; CRC cis rs780096 0.526 rs13472 chr2:27600239 G/A cg24768116 chr2:27665128 KRTCAP3 -0.35 -7.58 -0.39 3.54e-13 Total body bone mineral density; CRC cis rs35883536 0.611 rs72977390 chr1:101107147 C/T cg14515779 chr1:101123966 NA -0.33 -5.87 -0.31 1.04e-8 Monocyte count; CRC cis rs35883536 0.846 rs964905 chr1:101087131 T/C cg14515779 chr1:101123966 NA 0.41 7.59 0.39 3.29e-13 Monocyte count; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg08165532 chr3:133293146 CDV3 0.4 6.45 0.34 3.91e-10 Liver disease severity in Alagille syndrome; CRC cis rs2749592 0.513 rs1208708 chr10:38085576 A/G cg25517755 chr10:38738941 LOC399744 -0.42 -6.1 -0.32 2.99e-9 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs875971 0.545 rs316306 chr7:65618674 G/A cg18876405 chr7:65276391 NA -0.44 -6.13 -0.32 2.45e-9 Aortic root size; CRC cis rs6951245 0.572 rs73264010 chr7:1040477 T/C cg24642844 chr7:1081250 C7orf50 -0.74 -6.75 -0.35 6.89e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs1950626 0.833 rs1951025 chr14:101406022 T/A cg02351406 chr14:101447389 SNORD114-20;SNORD114-21 0.95 16.09 0.66 2.16e-43 Pelvic organ prolapse (moderate/severe); CRC cis rs9443189 0.526 rs10943250 chr6:76208445 C/G cg01950844 chr6:76311363 SENP6 0.73 9.74 0.47 7.23e-20 Prostate cancer; CRC cis rs7635838 0.684 rs346079 chr3:11328139 G/A cg00170343 chr3:11313890 ATG7 0.48 7.46 0.38 7.73e-13 HDL cholesterol; CRC cis rs2108225 0.934 rs4730269 chr7:107455719 T/G cg18560240 chr7:107437656 SLC26A3 -0.63 -9.77 -0.47 5.91e-20 Ulcerative colitis; CRC cis rs1005277 0.579 rs1740735 chr10:38497777 A/C cg25517755 chr10:38738941 LOC399744 -0.4 -5.89 -0.31 9.38e-9 Extrinsic epigenetic age acceleration; CRC cis rs3026101 0.578 rs1806237 chr17:5295399 C/T cg25236894 chr17:5323110 RPAIN;NUP88 0.42 6.84 0.35 3.98e-11 Body mass index; CRC cis rs9359856 0.564 rs56224741 chr6:90475231 C/T cg13799429 chr6:90582589 CASP8AP2 -0.72 -7.25 -0.37 3.03e-12 Bipolar disorder; CRC cis rs7904368 0.659 rs3740169 chr10:16873547 C/T cg23933602 chr10:16859644 RSU1 0.51 6.54 0.34 2.42e-10 Ratio of the peak velocity of the mitral E-Wave divided by the peak velocity of the mitral A-wave.; CRC cis rs2067615 0.524 rs754184 chr12:107117521 A/G cg13491945 chr12:107078410 RFX4 0.34 6.01 0.31 5.01e-9 Heart rate; CRC trans rs9914544 0.545 rs4924945 chr17:18813160 A/G cg21372672 chr17:16614065 CCDC144A -0.39 -6.07 -0.32 3.61e-9 Educational attainment (years of education); CRC cis rs4713118 0.868 rs7756968 chr6:27734954 C/G cg12172441 chr6:28176163 NA 0.58 6.39 0.33 5.51e-10 Parkinson's disease; CRC cis rs735396 1.000 rs1169311 chr12:121440731 C/T cg02403541 chr12:121454288 C12orf43 0.45 6.72 0.35 7.97e-11 N-glycan levels; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg11861043 chr3:49131662 QRICH1 0.43 6.05 0.32 3.86e-9 Response to antipsychotic treatment; CRC cis rs1865760 0.663 rs9348704 chr6:26000393 A/C cg16482183 chr6:26056742 HIST1H1C 0.5 7.42 0.38 1e-12 Height; CRC cis rs4689592 0.503 rs11937667 chr4:7057037 C/G cg19539972 chr4:7069911 GRPEL1 -0.82 -9.15 -0.45 6.29e-18 Monocyte percentage of white cells; CRC trans rs11466653 1.000 rs6856864 chr4:38778832 T/C cg11403706 chr22:49042600 FAM19A5 0.62 6.11 0.32 2.76e-9 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs6674176 0.597 rs12127737 chr1:44402565 G/A cg15962314 chr1:44399869 ARTN 0.32 6.23 0.32 1.41e-9 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Cognitive ability; CRC cis rs7086627 0.515 rs7078254 chr10:82212193 C/T cg09626299 chr10:82213104 TSPAN14 -0.37 -6.19 -0.32 1.83e-9 Post bronchodilator FEV1; CRC cis rs875971 0.862 rs778705 chr7:65861115 G/A cg18876405 chr7:65276391 NA 0.54 8.69 0.43 1.77e-16 Aortic root size; CRC cis rs4713118 0.513 rs149878 chr6:27878738 T/G cg17949981 chr6:28129498 ZNF389 0.42 5.85 0.31 1.18e-8 Parkinson's disease; CRC cis rs2625529 0.689 rs10851847 chr15:72111760 T/C cg16672083 chr15:72433130 SENP8 -0.45 -6.77 -0.35 6.04e-11 Red blood cell count; CRC cis rs6502050 0.769 rs9898542 chr17:80119682 C/T cg09264619 chr17:80180166 NA -0.35 -5.93 -0.31 7.47e-9 Life satisfaction; CRC cis rs1524976 1.000 rs62255273 chr3:65452827 C/A cg16238336 chr3:65465873 MAGI1 -0.53 -7.53 -0.38 4.96e-13 PR interval; CRC cis rs9462846 0.811 rs6939207 chr6:42879486 A/G cg21280719 chr6:42927975 GNMT -0.34 -6.54 -0.34 2.38e-10 Blood protein levels; CRC cis rs9303280 0.806 rs35569035 chr17:38035624 C/T cg17344932 chr17:38183730 MED24;SNORD124 0.37 5.91 0.31 8.63e-9 Self-reported allergy; CRC cis rs2836974 0.544 rs8128919 chr21:40711862 C/T cg17971929 chr21:40555470 PSMG1 0.52 7.25 0.37 2.91e-12 Cognitive function; CRC cis rs9783347 0.890 rs11024634 chr11:18392074 G/A cg15585147 chr11:18324498 HPS5 0.44 6.11 0.32 2.77e-9 Pancreatic cancer; CRC cis rs2404602 0.716 rs17363713 chr15:76746128 G/C cg22467129 chr15:76604101 ETFA -0.45 -7.67 -0.39 1.97e-13 Blood metabolite levels; CRC cis rs561341 1.000 rs4795669 chr17:30244701 C/T cg12193833 chr17:30244370 NA -0.69 -8.22 -0.41 4.75e-15 Hip circumference adjusted for BMI; CRC cis rs3824867 0.920 rs9919526 chr11:47451623 C/T cg05585544 chr11:47624801 NA 0.41 6.33 0.33 7.9e-10 Mean corpuscular hemoglobin; CRC cis rs425277 0.628 rs3107147 chr1:2048729 G/A cg12639453 chr1:2035780 PRKCZ -0.37 -6.93 -0.36 2.24e-11 Height; CRC cis rs2019137 0.560 rs10175462 chr2:113988492 G/A cg07772999 chr2:113993052 PAX8;LOC440839;LOC654433 0.54 8.28 0.42 3.07e-15 Lymphocyte counts; CRC cis rs860295 0.665 rs12028416 chr1:155401161 G/T cg02153340 chr1:155202674 NA -0.58 -6.85 -0.35 3.57e-11 Body mass index; CRC cis rs2976388 0.967 rs2976395 chr8:143763750 G/A cg20041105 chr8:143859282 LYNX1 -0.32 -5.7 -0.3 2.64e-8 Urinary tract infection frequency; CRC cis rs6835098 0.962 rs3733477 chr4:174090004 G/A cg08422745 chr4:174089978 GALNT7 -0.98 -16.63 -0.68 1.7e-45 Dementia and core Alzheimer's disease neuropathologic changes; CRC cis rs11214589 0.774 rs7107223 chr11:113255574 A/T cg14159747 chr11:113255604 NA 0.62 12.68 0.57 2.89e-30 Neuroticism; CRC cis rs7945705 0.870 rs10840142 chr11:8906078 A/G cg14711859 chr11:8959438 ASCL3 -0.51 -8.37 -0.42 1.67e-15 Hemoglobin concentration; CRC trans rs9329221 0.527 rs7833781 chr8:10333477 A/G cg06636001 chr8:8085503 FLJ10661 0.51 7.6 0.39 3.15e-13 Neuroticism; CRC cis rs6570726 0.935 rs411641 chr6:145827532 G/A cg05347473 chr6:146136440 FBXO30 0.37 6.0 0.31 5.27e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs4862750 0.872 rs6821507 chr4:187876829 G/T cg06074448 chr4:187884817 NA 0.58 10.88 0.51 9.75e-24 Lobe attachment (rater-scored or self-reported); CRC cis rs709400 1.000 rs709400 chr14:104149475 A/G cg24130564 chr14:104152367 KLC1 -0.43 -6.45 -0.33 4.11e-10 Body mass index; CRC cis rs6502050 0.731 rs35156322 chr17:80096323 T/C cg22110888 chr17:80059540 CCDC57 0.4 6.44 0.33 4.17e-10 Life satisfaction; CRC cis rs1348850 0.567 rs7605493 chr2:178534983 C/G cg02961200 chr2:178257176 LOC100130691;AGPS 0.51 7.07 0.36 9.06e-12 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs4150161 0.656 rs1056612 chr16:84211788 G/C cg10106505 chr16:84220380 TAF1C -0.72 -6.56 -0.34 2.14e-10 Systolic blood pressure response to hydrochlorothiazide in hypertension; CRC cis rs10504229 0.861 rs6990796 chr8:58183097 G/C cg05313129 chr8:58192883 C8orf71 -0.47 -6.99 -0.36 1.49e-11 Developmental language disorder (linguistic errors); CRC cis rs13108904 0.967 rs4405964 chr4:1278814 A/G cg05665937 chr4:1216051 CTBP1 0.4 5.8 0.3 1.54e-8 Obesity-related traits; CRC cis rs6500395 0.962 rs9936883 chr16:48676443 G/A cg04672837 chr16:48644449 N4BP1 0.45 6.67 0.35 1.09e-10 Response to tocilizumab in rheumatoid arthritis; CRC cis rs2836950 0.527 rs2836958 chr21:40623526 T/C cg17971929 chr21:40555470 PSMG1 -0.53 -7.46 -0.38 7.94e-13 Menarche (age at onset); CRC trans rs11098499 0.535 rs7671759 chr4:120248094 A/C cg25214090 chr10:38739885 LOC399744 0.54 8.52 0.43 5.98e-16 Corneal astigmatism; CRC trans rs8035957 1.000 rs4924273 chr15:38846738 C/G cg08354699 chr15:63796895 USP3 -0.52 -6.28 -0.33 1.06e-9 Type 1 diabetes; CRC cis rs40363 0.723 rs2736 chr16:3536872 G/A cg22508957 chr16:3507546 NAT15 -0.81 -8.45 -0.42 9.6e-16 Tuberculosis; CRC cis rs9467711 0.606 rs2393667 chr6:26421345 T/C cg12315302 chr6:26189340 HIST1H4D 0.77 5.99 0.31 5.51e-9 Autism spectrum disorder or schizophrenia; CRC cis rs7493 0.806 rs17876090 chr7:95053404 A/T cg19678392 chr7:94953810 PON1 -0.61 -7.49 -0.38 6.42e-13 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs9527 0.590 rs10883843 chr10:104947493 C/G cg04362960 chr10:104952993 NT5C2 0.59 8.15 0.41 7.45e-15 Arsenic metabolism; CRC cis rs9814567 1.000 rs13089966 chr3:134279197 A/G cg06541857 chr3:134203789 ANAPC13;CEP63 0.39 5.74 0.3 2.15e-8 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC trans rs875971 0.660 rs2191268 chr7:66110224 C/T cg11190155 chr3:9975447 CRELD1 -0.43 -6.53 -0.34 2.51e-10 Aortic root size; CRC cis rs4713118 0.513 rs149951 chr6:28033087 T/C cg12172441 chr6:28176163 NA 0.51 7.07 0.36 9.54e-12 Parkinson's disease; CRC cis rs12142240 0.698 rs41294458 chr1:46810304 T/C cg14993813 chr1:46806288 NSUN4 -0.49 -6.22 -0.32 1.5e-9 Menopause (age at onset); CRC cis rs7539624 0.588 rs2186006 chr1:223901545 T/C cg10100437 chr1:223903862 CAPN2 0.45 6.33 0.33 8.07e-10 Schizophrenia; CRC cis rs881375 0.967 rs2416805 chr9:123676482 T/C cg09586646 chr9:123605570 PSMD5;LOC253039 0.51 7.01 0.36 1.38e-11 Rheumatoid arthritis; CRC cis rs11155671 0.517 rs9397058 chr6:150207249 C/T cg07701084 chr6:150067640 NUP43 0.49 7.17 0.37 4.95e-12 Testicular germ cell tumor; CRC cis rs72615157 0.561 rs113844570 chr7:99873778 A/C cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.48 5.8 0.3 1.56e-8 Lung function (FEV1/FVC); CRC cis rs911555 0.511 rs2296483 chr14:104029792 G/A cg24130564 chr14:104152367 KLC1 -0.76 -12.43 -0.57 2.33e-29 Intelligence (multi-trait analysis); CRC cis rs7811142 0.830 rs3087502 chr7:99955364 G/A cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.61 7.95 0.4 3e-14 Platelet count; CRC cis rs727505 0.754 rs55723877 chr7:124780899 T/A cg23710748 chr7:124431027 NA -0.68 -11.62 -0.54 2.1e-26 Lewy body disease; CRC cis rs2197308 0.740 rs11182251 chr12:37919611 C/T cg13010199 chr12:38710504 ALG10B -0.5 -7.25 -0.37 2.91e-12 Morning vs. evening chronotype; CRC cis rs4731207 0.596 rs10272889 chr7:124576641 A/G cg23710748 chr7:124431027 NA -0.39 -6.12 -0.32 2.67e-9 Cutaneous malignant melanoma; CRC cis rs8105895 0.935 rs62110990 chr19:22260441 G/T cg02657401 chr19:22469223 NA -0.35 -5.74 -0.3 2.14e-8 Body mass index (change over time); CRC cis rs2985684 0.802 rs8015368 chr14:50020510 G/A cg04989706 chr14:50066350 PPIL5 -0.56 -8.06 -0.41 1.4e-14 Carotid intima media thickness; CRC cis rs10046574 0.831 rs10279987 chr7:135094763 A/G cg27474649 chr7:135195673 CNOT4 0.64 5.68 0.3 2.95e-8 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs787274 0.543 rs10114623 chr9:115631360 G/A cg13803584 chr9:115635662 SNX30 -0.65 -7.01 -0.36 1.35e-11 Age-related hearing impairment (SNP x SNP interaction); CRC trans rs1997103 1.000 rs6954474 chr7:55404847 A/G cg20935933 chr6:143382018 AIG1 0.51 6.69 0.35 9.51e-11 QRS interval (sulfonylurea treatment interaction); CRC cis rs41271473 0.526 rs12143098 chr1:228720965 A/C cg16512390 chr1:228756714 NA 0.64 6.81 0.35 4.74e-11 Chronic lymphocytic leukemia; CRC cis rs6570726 0.791 rs6570695 chr6:145911286 C/A cg13319975 chr6:146136371 FBXO30 -0.44 -6.44 -0.33 4.17e-10 Lobe attachment (rater-scored or self-reported); CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg09015484 chr9:96929106 NA 0.46 5.96 0.31 6.34e-9 Thyroid stimulating hormone; CRC cis rs6088590 0.523 rs6058084 chr20:33183804 C/T cg08999081 chr20:33150536 PIGU 0.64 12.31 0.56 6.53e-29 Coronary artery disease; CRC cis rs274567 0.501 rs272856 chr5:131687081 G/C cg09877947 chr5:131593287 PDLIM4 0.43 6.86 0.35 3.41e-11 Blood metabolite levels; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg06529439 chr2:88991002 RPIA 0.41 6.55 0.34 2.24e-10 Liver disease severity in Alagille syndrome; CRC cis rs10540 0.686 rs12421266 chr11:537120 C/T cg15790184 chr11:494944 RNH1 0.57 5.71 0.3 2.59e-8 Body mass index; CRC cis rs367615 0.679 rs10070786 chr5:108815081 T/G cg17395555 chr5:108820864 NA 0.44 8.88 0.44 4.41e-17 Colorectal cancer (SNP x SNP interaction); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg14903685 chr15:70391316 TLE3 0.37 6.06 0.32 3.65e-9 Liver disease severity in Alagille syndrome; CRC cis rs7412746 0.658 rs57818453 chr1:150763139 G/A cg17724175 chr1:150552817 MCL1 0.49 7.3 0.37 2.19e-12 Melanoma; CRC cis rs2836974 0.932 rs8129416 chr21:40617145 C/T cg17971929 chr21:40555470 PSMG1 0.82 11.82 0.55 4.31e-27 Cognitive function; CRC cis rs868943 0.743 rs13213124 chr6:116335637 A/G cg15226275 chr6:116381976 FRK 0.31 7.35 0.38 1.57e-12 Total cholesterol levels; CRC trans rs1005277 0.505 rs200936 chr10:38134935 T/C cg23533926 chr12:111358616 MYL2 -0.44 -6.54 -0.34 2.35e-10 Extrinsic epigenetic age acceleration; CRC cis rs8062405 0.823 rs7202948 chr16:28558289 T/A cg16576597 chr16:28551801 NUPR1 0.46 7.02 0.36 1.28e-11 Cognitive ability (multi-trait analysis);Cognitive ability; CRC cis rs950776 0.518 rs4886572 chr15:78837452 A/G cg06917634 chr15:78832804 PSMA4 -0.67 -10.68 -0.51 4.82e-23 Sudden cardiac arrest; CRC cis rs9649213 0.574 rs6961790 chr7:98007993 C/G cg00277769 chr7:97922759 BAIAP2L1 -0.58 -10.09 -0.49 5.09e-21 Prostate cancer (SNP x SNP interaction); CRC cis rs17376456 0.877 rs10060462 chr5:93455073 C/T cg25358565 chr5:93447407 FAM172A 1.02 10.38 0.5 4.9e-22 Diabetic retinopathy; CRC cis rs4862750 0.872 rs9998172 chr4:187898773 T/C cg06074448 chr4:187884817 NA -0.6 -11.05 -0.52 2.44e-24 Lobe attachment (rater-scored or self-reported); CRC cis rs73206853 0.719 rs28665218 chr12:110809859 C/A cg12870014 chr12:110450643 ANKRD13A 0.64 7.86 0.4 5.46e-14 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC cis rs6951245 0.872 rs75280240 chr7:1058511 C/T cg03188948 chr7:1209495 NA 0.58 6.0 0.31 5.09e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs7617773 0.780 rs13082158 chr3:48372470 T/C cg11946769 chr3:48343235 NME6 0.74 9.85 0.48 3.18e-20 Coronary artery disease; CRC cis rs7512552 0.768 rs7517441 chr1:150283643 A/T cg15654264 chr1:150340011 RPRD2 -0.57 -7.92 -0.4 3.63e-14 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); CRC cis rs2153535 0.584 rs9502721 chr6:8541379 G/A cg07606381 chr6:8435919 SLC35B3 0.68 11.15 0.52 1.04e-24 Motion sickness; CRC cis rs9443645 0.901 rs9448596 chr6:79629429 T/C cg05283184 chr6:79620031 NA -0.56 -8.84 -0.44 5.83e-17 Intelligence (multi-trait analysis); CRC cis rs877282 0.898 rs11253343 chr10:765117 C/T cg17470449 chr10:769945 NA 0.66 8.48 0.42 7.57e-16 Uric acid levels; CRC cis rs644799 0.687 rs3748252 chr11:95519195 A/T cg03916912 chr11:95522834 CEP57;FAM76B -0.84 -15.11 -0.64 1.57e-39 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs9308731 0.644 rs3789068 chr2:111909247 A/G cg04202892 chr2:111875749 ACOXL 0.48 7.9 0.4 4.16e-14 Chronic lymphocytic leukemia; CRC cis rs9858542 0.953 rs1801143 chr3:49570200 C/T cg00383909 chr3:49044727 WDR6 0.45 5.88 0.31 1.01e-8 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs7635838 0.654 rs4684766 chr3:11285474 G/A cg00170343 chr3:11313890 ATG7 0.56 8.42 0.42 1.16e-15 HDL cholesterol; CRC cis rs62458065 0.513 rs7805536 chr7:32573570 T/C cg20159608 chr7:32802032 NA -0.63 -8.09 -0.41 1.13e-14 Metabolite levels (HVA/MHPG ratio); CRC cis rs9916302 0.904 rs2338797 chr17:37548241 G/A cg07936489 chr17:37558343 FBXL20 0.84 13.35 0.59 8.87e-33 Glomerular filtration rate (creatinine); CRC cis rs4665809 0.590 rs2891496 chr2:26452605 G/A cg22920501 chr2:26401640 FAM59B 0.85 12.21 0.56 1.54e-28 Gut microbiome composition (summer); CRC trans rs6951245 0.744 rs1133122 chr7:1192572 C/A cg13565492 chr6:43139072 SRF -0.73 -8.04 -0.41 1.6e-14 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs2952156 0.920 rs2517951 chr17:37853097 C/T cg20243544 chr17:37824526 PNMT 0.57 9.06 0.45 1.21e-17 Asthma; CRC cis rs12477438 0.520 rs6743355 chr2:99732360 C/G cg14399236 chr2:99771627 LIPT1;TSGA10 0.82 14.43 0.62 6.73e-37 Chronic sinus infection; CRC trans rs6539288 0.803 rs10778517 chr12:107341664 G/T cg14873739 chr2:70780723 TGFA -0.42 -6.03 -0.32 4.37e-9 Total body bone mineral density; CRC cis rs7615952 0.641 rs7632497 chr3:125783086 A/C cg18479299 chr3:125709523 NA -0.55 -6.61 -0.34 1.6e-10 Blood pressure (smoking interaction); CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg09011732 chr2:74730507 LOC151534;LBX2 0.42 6.64 0.34 1.27e-10 Obesity-related traits; CRC cis rs67311347 0.784 rs13326389 chr3:40459724 A/G cg24209194 chr3:40518798 ZNF619 0.43 6.3 0.33 9.55e-10 Renal cell carcinoma; CRC cis rs6424115 0.964 rs2473375 chr1:24136545 C/T cg10978503 chr1:24200527 CNR2 0.48 8.43 0.42 1.11e-15 Immature fraction of reticulocytes; CRC cis rs7258465 1.000 rs3810429 chr19:18543270 G/T cg01065977 chr19:18549689 ISYNA1 -0.4 -6.01 -0.31 4.94e-9 Breast cancer; CRC cis rs7223966 1.000 rs7217982 chr17:61832150 C/T cg23090583 chr17:61904693 PSMC5;FTSJ3 0.51 6.34 0.33 7.46e-10 Hip circumference adjusted for BMI;Body mass index; CRC cis rs4713118 0.539 rs200988 chr6:27819353 A/C cg25164649 chr6:28176230 NA 0.57 8.01 0.4 1.97e-14 Parkinson's disease; CRC cis rs4713118 0.869 rs9283883 chr6:27715470 T/A cg02683197 chr6:28174875 NA 0.63 8.5 0.42 6.49e-16 Parkinson's disease; CRC cis rs116095464 0.614 rs10059220 chr5:242813 C/T cg22496380 chr5:211416 CCDC127 -1.01 -10.08 -0.49 5.32e-21 Breast cancer; CRC trans rs6500957 0.920 rs17648524 chr16:7459683 C/G cg17304336 chr11:65343565 EHBP1L1 0.46 6.65 0.34 1.19e-10 Spherical equivalent (joint analysis main effects and education interaction); CRC cis rs1153858 1.000 rs7181167 chr15:45686236 C/G cg10760299 chr15:45669010 GATM 0.51 7.74 0.39 1.26e-13 Homoarginine levels; CRC cis rs490234 0.934 rs13284832 chr9:128435126 A/C cg14078157 chr9:128172775 NA -0.37 -6.04 -0.32 4.18e-9 Mean arterial pressure; CRC cis rs3126085 0.877 rs4415568 chr1:152181207 G/A cg09127314 chr1:152161683 NA 0.53 6.69 0.35 9.52e-11 Atopic dermatitis; CRC cis rs6952808 0.771 rs10244946 chr7:1921068 A/G cg04267008 chr7:1944627 MAD1L1 0.71 11.09 0.52 1.65e-24 Bipolar disorder and schizophrenia; CRC cis rs6502050 0.835 rs6502059 chr17:80082886 T/C cg13198984 chr17:80129470 CCDC57 -0.48 -8.56 -0.43 4.49e-16 Life satisfaction; CRC cis rs4563143 0.514 rs73029079 chr19:29294903 A/G cg12756686 chr19:29218302 NA 0.64 8.77 0.44 9.78e-17 Methadone dose in opioid dependence; CRC cis rs769267 0.965 rs4808937 chr19:19398005 A/G cg02546618 chr19:19431379 KIAA0892;SF4 0.46 6.35 0.33 7.02e-10 Tonsillectomy; CRC cis rs7258465 1.000 rs271623 chr19:18628947 A/G cg10790698 chr19:18539756 SSBP4 -0.46 -8.93 -0.44 3.15e-17 Breast cancer; CRC cis rs11945232 1.000 rs6854710 chr4:88334640 A/G cg23841344 chr4:88312519 HSD17B11 -0.52 -6.72 -0.35 8.02e-11 Intelligence (multi-trait analysis); CRC cis rs1580019 0.921 rs1580023 chr7:32497881 G/A cg06627557 chr7:32535165 LSM5;AVL9 0.71 11.2 0.53 6.71e-25 Cognitive ability; CRC cis rs1046896 0.553 rs8073413 chr17:80836005 G/A cg19046167 chr17:80928561 B3GNTL1 0.51 7.16 0.37 5.45e-12 Glycated hemoglobin levels; CRC cis rs67340775 0.541 rs200974 chr6:27855845 A/G cg26587870 chr6:27730563 NA -0.56 -6.44 -0.33 4.31e-10 Lung cancer in ever smokers; CRC trans rs11039798 1.000 rs11039904 chr11:48682597 T/A cg03929089 chr4:120376271 NA 0.63 6.06 0.32 3.73e-9 Axial length; CRC cis rs9522267 0.535 rs11069898 chr13:112231512 C/T cg14352298 chr13:112236639 NA 0.29 6.66 0.34 1.18e-10 Hepatitis; CRC cis rs7771547 0.573 rs10440841 chr6:36399086 G/A cg07856975 chr6:36356162 ETV7 -0.4 -5.74 -0.3 2.15e-8 Platelet distribution width; CRC cis rs7705042 0.865 rs4912623 chr5:141505462 T/A cg08523384 chr5:141488047 NDFIP1 -0.33 -5.84 -0.31 1.23e-8 Asthma; CRC cis rs3772130 0.886 rs9825248 chr3:121568711 A/G cg20356878 chr3:121714668 ILDR1 0.52 8.21 0.41 5.11e-15 Cognitive performance; CRC cis rs394563 0.690 rs237009 chr6:149759552 C/T cg03678062 chr6:149772716 ZC3H12D -0.37 -6.64 -0.34 1.29e-10 Dupuytren's disease; CRC cis rs7666738 0.791 rs13120773 chr4:98972589 C/T cg05340658 chr4:99064831 C4orf37 0.6 9.35 0.46 1.41e-18 Colonoscopy-negative controls vs population controls; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg19229622 chr11:47291485 MADD 0.47 6.55 0.34 2.28e-10 Response to antipsychotic treatment; CRC cis rs17270561 0.609 rs9358884 chr6:25756592 A/G cg17691542 chr6:26056736 HIST1H1C 0.73 9.33 0.46 1.56e-18 Iron status biomarkers; CRC trans rs10802346 0.545 rs2362252 chr1:246371574 A/C cg22732515 chr19:44031385 ETHE1 0.69 10.35 0.5 6.57e-22 Fractional exhaled nitric oxide (childhood); CRC cis rs896854 0.846 rs2340584 chr8:95916811 A/G cg16049864 chr8:95962084 TP53INP1 -0.63 -11.1 -0.52 1.52e-24 Type 2 diabetes; CRC cis rs60871478 1.000 rs6460801 chr7:810506 T/C cg13844804 chr7:814759 HEATR2 0.67 8.56 0.43 4.26e-16 Cerebrospinal P-tau181p levels; CRC cis rs9443645 0.901 rs9352669 chr6:79584141 T/G cg05283184 chr6:79620031 NA -0.57 -9.21 -0.45 3.98e-18 Intelligence (multi-trait analysis); CRC trans rs6544773 0.764 rs340500 chr2:45080242 A/C cg10208897 chr5:178548229 ADAMTS2 0.35 5.98 0.31 5.79e-9 Mosquito bite size; CRC cis rs897984 0.542 rs11864839 chr16:31095251 G/C cg00531865 chr16:30841666 NA -0.42 -6.1 -0.32 2.93e-9 Dementia with Lewy bodies; CRC trans rs12188164 0.610 rs57433159 chr5:418725 C/T cg15371732 chr17:78194151 SLC26A11;SGSH 0.44 6.25 0.33 1.29e-9 Cystic fibrosis severity; CRC cis rs12956009 0.583 rs35970525 chr18:44882625 C/T cg19077165 chr18:44547161 KATNAL2 -0.39 -5.63 -0.3 3.95e-8 Educational attainment (years of education); CRC cis rs1580019 0.844 rs1037322 chr7:32501857 C/T cg07520158 chr7:32535189 LSM5;AVL9 0.49 6.81 0.35 4.6e-11 Cognitive ability; CRC cis rs7618915 0.571 rs6778844 chr3:52596398 C/T cg08222913 chr3:52553049 STAB1 0.36 6.49 0.34 3.11e-10 Bipolar disorder; CRC cis rs1046896 0.561 rs8076476 chr17:80861017 A/C cg16060761 chr17:80687452 NA -0.46 -5.95 -0.31 7.05e-9 Glycated hemoglobin levels; CRC cis rs7178572 0.568 rs28524916 chr15:77599002 T/A cg22256960 chr15:77711686 NA 0.63 8.83 0.44 6.14e-17 Type 2 diabetes; CRC cis rs67478160 0.654 rs11628240 chr14:104218135 A/G cg01849466 chr14:104193079 ZFYVE21 -0.49 -8.76 -0.43 1.06e-16 Schizophrenia; CRC cis rs7615952 0.932 rs6438948 chr3:125650045 A/T cg05084668 chr3:125655381 ALG1L 0.63 10.17 0.49 2.57e-21 Blood pressure (smoking interaction); CRC cis rs4253772 0.513 rs6008612 chr22:46707907 G/A cg03482458 chr22:46692211 CN5H6.4;GTSE1 0.57 7.8 0.4 8.11e-14 LDL cholesterol;Cholesterol, total; CRC cis rs3096299 0.719 rs2911262 chr16:89515041 C/T cg01788221 chr16:89496183 ANKRD11 -0.43 -6.36 -0.33 6.69e-10 Multiple myeloma (IgH translocation); CRC cis rs853679 0.517 rs4713137 chr6:28083521 C/G cg21251018 chr6:28226885 NKAPL 0.48 6.19 0.32 1.84e-9 Depression; CRC cis rs853679 0.517 rs4711165 chr6:28115184 T/G cg02631126 chr6:28058918 ZSCAN12L1 0.29 5.91 0.31 8.38e-9 Depression; CRC cis rs1348850 0.872 rs4893959 chr2:178400204 G/A cg02961200 chr2:178257176 LOC100130691;AGPS 0.56 8.02 0.4 1.82e-14 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg09883524 chr16:89984247 MC1R 0.45 6.15 0.32 2.19e-9 Response to antipsychotic treatment; CRC cis rs9560113 0.960 rs61967677 chr13:112174044 A/G cg14154082 chr13:112174009 NA 0.35 5.71 0.3 2.54e-8 Menarche (age at onset); CRC cis rs2072510 0.593 rs2540499 chr12:96399869 A/C cg22491680 chr12:96389547 HAL 0.47 6.06 0.32 3.81e-9 Metabolite levels (small molecules and protein measures); CRC cis rs9372498 0.505 rs62422247 chr6:118987559 G/T cg15382696 chr6:118971807 C6orf204 0.59 7.1 0.36 7.52e-12 Diastolic blood pressure; CRC cis rs1656402 0.906 rs2276560 chr2:233450919 C/T cg03852847 chr2:233439513 NA -0.39 -6.73 -0.35 7.76e-11 Non-small cell lung cancer (survival); CRC cis rs11719291 0.915 rs11557629 chr3:48732223 G/A cg07636037 chr3:49044803 WDR6 -0.69 -6.98 -0.36 1.64e-11 Cognitive function; CRC cis rs4964805 0.606 rs7312606 chr12:104188385 C/G cg02344784 chr12:104178138 NT5DC3 0.79 15.0 0.64 4.21e-39 Attention deficit hyperactivity disorder; CRC cis rs4728302 0.869 rs12707130 chr7:133616739 G/T cg03336402 chr7:133662267 EXOC4 -0.46 -6.68 -0.35 1.01e-10 Intelligence;Intelligence (multi-trait analysis); CRC cis rs597539 0.652 rs602805 chr11:68662076 A/T cg21963583 chr11:68658836 MRPL21 0.63 11.58 0.54 3.15e-26 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs7089973 0.966 rs17721283 chr10:116644141 A/G cg23260525 chr10:116636907 FAM160B1 0.31 6.24 0.33 1.35e-9 Bipolar disorder or attention deficit hyperactivity disorder; CRC cis rs13191362 1.000 rs34192365 chr6:163012382 T/G cg06582575 chr6:163149167 PACRG;PARK2 0.76 10.41 0.5 4.01e-22 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs9733 0.650 rs61820165 chr1:150555987 C/T cg18016565 chr1:150552671 MCL1 -0.47 -7.19 -0.37 4.32e-12 Tonsillectomy; CRC trans rs1555895 0.611 rs3763722 chr10:859270 C/T cg16899823 chr10:58121153 ZWINT -0.39 -6.06 -0.32 3.76e-9 Survival in rectal cancer; CRC cis rs2073300 0.609 rs17757442 chr20:23421101 A/G cg12062639 chr20:23401060 NAPB -0.73 -6.64 -0.34 1.28e-10 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs1965732 1.000 rs11696000 chr2:3709907 A/G cg00999904 chr2:3704751 ALLC -0.44 -6.33 -0.33 8.03e-10 Response to inhaled corticosteroid treatment in asthma (change in FEV1); CRC cis rs28386778 0.897 rs9906247 chr17:61857314 T/C cg23090583 chr17:61904693 PSMC5;FTSJ3 1.06 20.41 0.75 2.17e-60 Prudent dietary pattern; CRC cis rs9291683 0.632 rs12508991 chr4:10041104 C/T cg00071950 chr4:10020882 SLC2A9 0.67 12.66 0.57 3.38e-30 Bone mineral density; CRC trans rs1814175 0.817 rs4084376 chr11:49831160 T/C cg03929089 chr4:120376271 NA -0.96 -18.49 -0.71 7.73e-53 Height; CRC cis rs2070488 0.965 rs6805386 chr3:38557921 T/C cg01465620 chr3:38496096 LOC100128640;ACVR2B -0.87 -16.16 -0.67 1.19e-43 Electrocardiographic conduction measures; CRC cis rs873946 0.504 rs3793681 chr10:134564451 T/C cg18305652 chr10:134549665 INPP5A 0.54 7.75 0.39 1.16e-13 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CRC trans rs2303319 0.504 rs1515182 chr2:162436934 A/G cg09481857 chr22:21368659 P2RX6;MGC16703 -0.65 -6.0 -0.31 5.13e-9 Cognitive function; CRC cis rs9399135 0.967 rs6929661 chr6:135328792 G/A cg24558204 chr6:135376177 HBS1L 0.51 8.13 0.41 8.55e-15 Red blood cell count; CRC cis rs7927771 0.524 rs7116346 chr11:47883880 G/A cg20307385 chr11:47447363 PSMC3 -0.45 -6.68 -0.35 9.91e-11 Subjective well-being; CRC cis rs10242455 0.702 rs17161726 chr7:99008395 C/G cg18809830 chr7:99032528 PTCD1 -0.93 -7.58 -0.39 3.66e-13 Blood metabolite levels; CRC cis rs9467711 0.606 rs34878490 chr6:26370572 C/T cg14345882 chr6:26364793 BTN3A2 0.65 5.74 0.3 2.17e-8 Autism spectrum disorder or schizophrenia; CRC cis rs4474465 0.790 rs6592785 chr11:78235095 C/T cg27205649 chr11:78285834 NARS2 0.48 5.69 0.3 2.79e-8 Alzheimer's disease (survival time); CRC cis rs10979 1.000 rs1054752 chr6:143890097 G/A cg25407410 chr6:143891975 LOC285740 -0.82 -13.4 -0.59 5.5e-33 Hypospadias; CRC cis rs7833790 0.724 rs6473309 chr8:82707880 A/G cg17211192 chr8:82754475 SNX16 -0.49 -6.94 -0.36 2.15e-11 Diastolic blood pressure; CRC cis rs5753618 0.561 rs4603880 chr22:31744721 T/C cg22777020 chr22:31556080 RNF185 0.54 6.27 0.33 1.12e-9 Colorectal cancer; CRC cis rs362272 0.505 rs13104157 chr4:3366950 T/C cg02993699 chr4:3415135 RGS12 -0.41 -6.72 -0.35 7.79e-11 Serum sulfate level; CRC cis rs9411298 0.630 rs9411299 chr9:139938793 C/G cg14024893 chr9:139943146 ENTPD2 -0.74 -10.41 -0.5 3.85e-22 Monocyte percentage of white cells; CRC cis rs45509595 0.841 rs370155 chr6:27782031 T/G cg03623178 chr6:28175578 NA 0.79 6.96 0.36 1.89e-11 Breast cancer; CRC cis rs2075371 0.796 rs1646644 chr7:134011817 A/T cg02659138 chr7:134003124 SLC35B4 0.39 6.65 0.34 1.22e-10 Mean platelet volume; CRC cis rs703842 1.000 rs1599932 chr12:58177943 G/A cg00677455 chr12:58241039 CTDSP2 0.64 8.66 0.43 2.14e-16 Multiple sclerosis; CRC cis rs1153858 1.000 rs11070456 chr15:45686835 G/A cg21132104 chr15:45694354 SPATA5L1 0.59 8.44 0.42 1.02e-15 Homoarginine levels; CRC cis rs5769707 0.616 rs6009786 chr22:50015145 A/G cg20744362 chr22:50050164 C22orf34 0.34 6.21 0.32 1.55e-9 Monocyte count;Monocyte percentage of white cells; CRC cis rs67340775 0.541 rs200966 chr6:27862152 T/C cg12273811 chr6:28175739 NA 0.6 6.3 0.33 9.28e-10 Lung cancer in ever smokers; CRC cis rs11122272 0.735 rs2808604 chr1:231538916 T/C cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.59 -8.84 -0.44 6.02e-17 Hemoglobin concentration; CRC cis rs2032447 0.714 rs199734 chr6:25940393 G/C cg18357526 chr6:26021779 HIST1H4A 0.73 10.62 0.51 7.64e-23 Intelligence (multi-trait analysis); CRC cis rs6964587 1.000 rs10488512 chr7:91753579 C/T cg17063962 chr7:91808500 NA 0.82 14.26 0.62 2.83e-36 Breast cancer; CRC cis rs7223966 0.883 rs2955250 chr17:61959740 C/T cg23090583 chr17:61904693 PSMC5;FTSJ3 0.46 5.7 0.3 2.67e-8 Hip circumference adjusted for BMI;Body mass index; CRC cis rs9611565 0.659 rs1569516 chr22:41910244 C/T cg03806693 chr22:41940476 POLR3H -1.14 -15.28 -0.64 3.27e-40 Vitiligo; CRC cis rs13118159 0.934 rs4974608 chr4:1356780 C/T cg24560729 chr4:1342394 KIAA1530 0.33 5.86 0.31 1.11e-8 Longevity; CRC cis rs6912958 0.874 rs9294381 chr6:88152681 A/T cg12350822 chr6:88032061 C6orf162;GJB7 -0.36 -6.84 -0.35 3.85e-11 Monocyte percentage of white cells; CRC cis rs7538876 0.903 rs6681150 chr1:17750685 G/A cg07965774 chr1:17746286 RCC2 0.33 6.15 0.32 2.26e-9 Basal cell carcinoma; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg03984733 chr9:116139085 HDHD3 0.47 6.02 0.31 4.74e-9 Thyroid stimulating hormone; CRC cis rs2243480 1.000 rs316325 chr7:65609518 G/A cg12463550 chr7:65579703 CRCP 0.7 6.45 0.34 3.98e-10 Diabetic kidney disease; CRC cis rs9463078 0.585 rs4072928 chr6:45291229 A/G cg25276700 chr6:44698697 NA -0.24 -5.75 -0.3 2.09e-8 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; CRC cis rs1799949 1.000 rs11654452 chr17:41189383 G/T cg19454999 chr17:41278357 BRCA1;NBR2 0.53 7.99 0.4 2.31e-14 Menopause (age at onset); CRC cis rs7208859 0.673 rs28588622 chr17:29245699 G/A cg14008862 chr17:28927542 LRRC37B2 0.54 5.79 0.3 1.66e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs6540556 0.769 rs9430017 chr1:209925058 C/T cg23920097 chr1:209922102 NA -0.49 -5.62 -0.3 4.03e-8 Red blood cell count; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg13402292 chr21:37667921 NA -0.38 -6.06 -0.32 3.82e-9 Liver disease severity in Alagille syndrome; CRC cis rs34891900 0.507 rs2535707 chr22:18181869 C/T cg19898043 chr22:18121309 BCL2L13 -0.53 -8.43 -0.42 1.06e-15 Sum neutrophil eosinophil counts; CRC cis rs116095464 0.558 rs10058428 chr5:235608 A/G cg22496380 chr5:211416 CCDC127 -0.91 -10.38 -0.5 5.2e-22 Breast cancer; CRC cis rs12410462 1.000 rs12410243 chr1:227669474 A/G cg04117972 chr1:227635322 NA 0.62 6.92 0.36 2.43e-11 Major depressive disorder; CRC cis rs4853012 0.941 rs78128123 chr2:74347525 C/T cg01017244 chr2:74357527 NA 0.73 9.04 0.45 1.42e-17 Gestational age at birth (maternal effect); CRC cis rs6951245 0.572 rs75818004 chr7:1047572 C/T cg24642844 chr7:1081250 C7orf50 -0.9 -7.59 -0.39 3.32e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs60871478 0.786 rs12532534 chr7:831891 G/A cg13798912 chr7:905769 UNC84A -0.53 -5.99 -0.31 5.65e-9 Cerebrospinal P-tau181p levels; CRC cis rs10504229 1.000 rs17805656 chr8:58180318 T/C cg05313129 chr8:58192883 C8orf71 -0.47 -6.99 -0.36 1.49e-11 Developmental language disorder (linguistic errors); CRC cis rs2440129 0.632 rs2292353 chr17:6903537 C/T cg05215272 chr17:6899095 ALOX12 0.59 10.89 0.51 8.99e-24 Tonsillectomy; CRC cis rs9469578 1.000 rs9469582 chr6:33715939 A/G cg18708504 chr6:33715942 IP6K3 0.66 7.52 0.38 5.12e-13 Phosphorus levels; CRC cis rs6860806 0.507 rs2631372 chr5:131703578 C/G cg09877947 chr5:131593287 PDLIM4 0.45 7.36 0.38 1.49e-12 Breast cancer; CRC cis rs4478858 0.647 rs11581476 chr1:31717675 C/T cg00250761 chr1:31883323 NA -0.44 -8.78 -0.44 9.19e-17 Alcohol dependence; CRC trans rs7615952 0.512 rs2922175 chr3:125361360 T/C cg17147758 chr8:6949321 NA -0.52 -7.2 -0.37 4.24e-12 Blood pressure (smoking interaction); CRC cis rs17376456 0.825 rs13155452 chr5:93164449 C/T cg25358565 chr5:93447407 FAM172A -0.96 -9.72 -0.47 8.81e-20 Diabetic retinopathy; CRC cis rs9916302 0.904 rs12600751 chr17:37553651 G/C cg07936489 chr17:37558343 FBXL20 0.78 11.09 0.52 1.7e-24 Glomerular filtration rate (creatinine); CRC cis rs10504229 0.683 rs55881798 chr8:58106406 T/C cg05313129 chr8:58192883 C8orf71 -0.43 -5.87 -0.31 1.08e-8 Developmental language disorder (linguistic errors); CRC cis rs6484504 0.512 rs2761594 chr11:31318244 A/G cg14844989 chr11:31128820 NA 0.36 6.29 0.33 1.01e-9 Red blood cell count; CRC cis rs4665809 0.590 rs7588328 chr2:26469788 G/A cg08067268 chr2:26466485 HADHB;HADHA 0.66 8.38 0.42 1.54e-15 Gut microbiome composition (summer); CRC cis rs9527 0.590 rs3740386 chr10:104931051 C/T cg04362960 chr10:104952993 NT5C2 0.61 8.4 0.42 1.37e-15 Arsenic metabolism; CRC cis rs13108904 0.901 rs7668661 chr4:1300172 A/G cg24560729 chr4:1342394 KIAA1530 0.34 6.27 0.33 1.1e-9 Obesity-related traits; CRC cis rs875971 1.000 rs6961155 chr7:65933295 T/C cg18876405 chr7:65276391 NA 0.52 8.85 0.44 5.32e-17 Aortic root size; CRC cis rs7044106 0.762 rs7044226 chr9:123466328 G/C cg09419670 chr9:123605666 PSMD5;LOC253039 0.75 12.0 0.55 8.81e-28 Hip circumference adjusted for BMI; CRC cis rs7662987 0.517 rs2602882 chr4:100040765 C/T cg12011299 chr4:100065546 ADH4 0.5 9.43 0.46 7.84e-19 Smoking initiation; CRC cis rs735539 0.636 rs9579928 chr13:21274807 C/G cg27499820 chr13:21296301 IL17D -0.39 -5.79 -0.3 1.6e-8 Dental caries; CRC cis rs4819052 0.766 rs4819035 chr21:46645715 A/C cg02159808 chr21:46707872 POFUT2;LOC642852 0.55 6.64 0.34 1.3100000000000001e-10 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs832540 0.931 rs702679 chr5:56221328 A/G cg20203395 chr5:56204925 C5orf35 -0.42 -5.95 -0.31 6.75e-9 Coronary artery disease; CRC cis rs6879260 1.000 rs888922 chr5:179731635 C/G cg26918954 chr5:179728553 GFPT2 -0.44 -7.37 -0.38 1.42e-12 Height; CRC cis rs6563739 0.655 rs4476043 chr13:40225608 G/A cg00026919 chr13:40226031 NA 0.48 6.12 0.32 2.69e-9 Menarche (age at onset); CRC cis rs17532515 0.628 rs882930 chr4:141458485 T/G cg09181644 chr4:141490428 UCP1 -0.32 -5.76 -0.3 1.89e-8 Select biomarker traits; CRC cis rs6988636 1.000 rs13261021 chr8:124190239 G/A cg27053337 chr8:124217698 FAM83A 0.43 6.65 0.34 1.21e-10 Urinary uromodulin levels; CRC cis rs6460942 0.732 rs73677575 chr7:12286532 A/G cg20607287 chr7:12443886 VWDE -0.54 -5.69 -0.3 2.87e-8 Coronary artery disease; CRC cis rs11212617 1.000 rs11212615 chr11:108281267 G/A cg14761454 chr11:108092087 ATM;NPAT 0.43 6.43 0.33 4.4e-10 Response to metformin in type 2 diabetes (glycemic); CRC trans rs6703335 0.870 rs10803142 chr1:243598234 A/G cg05303289 chr1:40506118 CAP1 0.43 6.05 0.32 3.84e-9 Schizophrenia;Schizophrenia, schizoaffective disorder or bipolar disorder; CRC cis rs7618915 0.501 rs2336146 chr3:52626646 A/G cg18099408 chr3:52552593 STAB1 -0.48 -8.1 -0.41 1.06e-14 Bipolar disorder; CRC cis rs6545883 0.929 rs1186710 chr2:61688727 T/A cg15711740 chr2:61764176 XPO1 -0.43 -5.72 -0.3 2.41e-8 Tuberculosis; CRC cis rs11212617 0.870 rs227078 chr11:108250381 G/A cg14761454 chr11:108092087 ATM;NPAT 0.44 6.76 0.35 6.12e-11 Response to metformin in type 2 diabetes (glycemic); CRC cis rs1005277 0.557 rs1854563 chr10:38434961 G/A cg25427524 chr10:38739819 LOC399744 -0.76 -13.4 -0.59 5.88e-33 Extrinsic epigenetic age acceleration; CRC trans rs853679 0.766 rs9368561 chr6:28168343 C/T cg06606381 chr12:133084897 FBRSL1 -0.99 -8.38 -0.42 1.52e-15 Depression; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg09106556 chr19:35168274 ZNF302 0.41 6.14 0.32 2.33e-9 Liver disease severity in Alagille syndrome; CRC cis rs9322193 0.923 rs9322207 chr6:149978321 G/A cg13206674 chr6:150067644 NUP43 0.65 9.81 0.48 4.27e-20 Lung cancer; CRC cis rs4919694 0.572 rs4917995 chr10:104845443 A/T cg04362960 chr10:104952993 NT5C2 -0.86 -9.28 -0.46 2.41e-18 Arsenic metabolism; CRC cis rs2075371 0.966 rs1646676 chr7:133999267 G/A cg11752832 chr7:134001865 SLC35B4 0.5 7.7 0.39 1.61e-13 Mean platelet volume; CRC trans rs9291683 0.530 rs35908990 chr4:9976105 G/A cg26043149 chr18:55253948 FECH 0.54 8.28 0.42 3.09e-15 Bone mineral density; CRC cis rs1552244 1.000 rs6807846 chr3:10134491 G/T cg10729496 chr3:10149963 C3orf24 0.49 6.55 0.34 2.22e-10 Alzheimer's disease; CRC cis rs2832077 0.527 rs9980449 chr21:30224889 G/C cg24692254 chr21:30365293 RNF160 -0.45 -6.66 -0.34 1.12e-10 Cognitive test performance; CRC cis rs2153535 0.580 rs7741456 chr6:8452424 G/A cg07606381 chr6:8435919 SLC35B3 0.68 10.85 0.51 1.2e-23 Motion sickness; CRC cis rs2120019 1.000 rs12185102 chr15:75352201 G/A cg11632617 chr15:75315747 PPCDC -0.52 -7.05 -0.36 1.04e-11 Blood trace element (Zn levels); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg04986989 chr1:146714493 CHD1L 0.44 6.03 0.32 4.35e-9 Response to antipsychotic treatment; CRC cis rs11098499 1.000 rs13116504 chr4:120209412 A/C cg09307838 chr4:120376055 NA 0.63 9.72 0.47 8.34e-20 Corneal astigmatism; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg08900073 chr11:118796721 NA 0.51 7.38 0.38 1.26e-12 Intelligence (multi-trait analysis); CRC cis rs344364 0.511 rs2917515 chr16:1945271 G/C cg09830162 chr16:1889614 FAHD1;C16orf73 -0.82 -9.5 -0.46 4.38e-19 Glomerular filtration rate in chronic kidney disease; CRC cis rs7662987 0.517 rs2851256 chr4:100039549 G/A cg13256891 chr4:100009986 ADH5 0.63 8.54 0.43 4.99e-16 Smoking initiation; CRC cis rs490234 0.588 rs34983978 chr9:128169170 G/A cg14078157 chr9:128172775 NA -0.41 -6.74 -0.35 7.31e-11 Mean arterial pressure; CRC cis rs3790455 0.610 rs1171561 chr1:156455898 G/A cg14087168 chr1:156450669 MEF2D -0.38 -6.53 -0.34 2.52e-10 Migraine; CRC trans rs10982213 0.830 rs2274163 chr9:117188714 C/T cg00807877 chr14:70095319 KIAA0247 0.39 6.18 0.32 1.88e-9 Interleukin-6 levels; CRC cis rs9368481 0.594 rs7768814 chr6:26892036 C/A cg18867708 chr6:26865862 GUSBL1 0.44 6.37 0.33 6.37e-10 Autism spectrum disorder or schizophrenia; CRC trans rs28735056 0.904 rs11665111 chr18:77622996 T/C cg03973167 chr4:185394988 IRF2 -0.44 -6.3 -0.33 9.77e-10 Schizophrenia; CRC cis rs9398803 0.865 rs1490388 chr6:126835655 C/T cg19875578 chr6:126661172 C6orf173 0.42 5.86 0.31 1.15e-8 Male-pattern baldness; CRC cis rs995000 0.931 rs1168020 chr1:63009956 C/T cg19896129 chr1:63156450 NA -0.44 -6.82 -0.35 4.3e-11 Triglyceride levels; CRC cis rs9303401 0.659 rs7224276 chr17:56897827 C/T cg02118635 chr17:56770003 RAD51C;TEX14 0.77 9.98 0.48 1.15e-20 Cognitive test performance; CRC cis rs514406 0.708 rs480299 chr1:53320274 G/T cg24675658 chr1:53192096 ZYG11B -0.68 -10.09 -0.49 4.94e-21 Monocyte count; CRC trans rs7395662 0.591 rs11039766 chr11:48488715 T/C cg21153622 chr11:89784906 NA -0.51 -8.55 -0.43 4.76e-16 HDL cholesterol; CRC cis rs7618915 0.501 rs6617 chr3:52740182 C/G cg15147215 chr3:52552868 STAB1 -0.61 -10.28 -0.49 1.08e-21 Bipolar disorder; CRC trans rs8123881 0.733 rs7268466 chr20:15810676 C/T cg02375201 chr1:27114675 PIGV 0.54 5.97 0.31 6.17e-9 Body mass index; CRC cis rs950027 0.620 rs1617984 chr15:45622662 A/G cg21132104 chr15:45694354 SPATA5L1 0.41 5.84 0.31 1.25e-8 Response to fenofibrate (adiponectin levels); CRC cis rs6951245 1.000 rs76804143 chr7:1082021 C/T cg20603222 chr7:1096387 C7orf50;GPR146 -0.68 -7.91 -0.4 4e-14 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs4964805 1.000 rs4964794 chr12:104194418 T/C cg02344784 chr12:104178138 NT5DC3 0.55 8.21 0.41 4.99e-15 Attention deficit hyperactivity disorder; CRC cis rs2976388 0.609 rs2585150 chr8:143792669 C/T cg04969067 chr8:143858791 LYNX1 0.45 7.58 0.39 3.66e-13 Urinary tract infection frequency; CRC cis rs17818399 0.653 rs34050156 chr2:46777646 A/G cg21681030 chr2:46777652 RHOQ 0.52 7.39 0.38 1.23e-12 Height; CRC cis rs7208859 0.623 rs55811708 chr17:29104731 G/T cg01831904 chr17:28903510 LRRC37B2 -0.62 -6.35 -0.33 7.36e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs909341 0.710 rs6010998 chr20:62294402 A/T cg16989086 chr20:62203971 PRIC285 -0.5 -6.38 -0.33 6.07e-10 Atopic dermatitis; CRC cis rs6952808 0.724 rs7792631 chr7:1982779 C/T cg04267008 chr7:1944627 MAD1L1 -0.74 -10.18 -0.49 2.5e-21 Bipolar disorder and schizophrenia; CRC cis rs4588572 0.643 rs1019739 chr5:77770241 G/C cg11446398 chr5:77624930 NA 0.46 6.34 0.33 7.62e-10 Triglycerides; CRC cis rs10256972 0.684 rs2363279 chr7:1096143 A/G cg23978390 chr7:1156363 C7orf50 0.44 6.02 0.31 4.75e-9 Longevity;Endometriosis; CRC cis rs2243480 0.901 rs13237344 chr7:66022256 T/A cg12463550 chr7:65579703 CRCP 0.69 6.3 0.33 9.48e-10 Diabetic kidney disease; CRC cis rs11190604 0.767 rs11190513 chr10:102165238 A/G cg16342193 chr10:102329863 NA -0.35 -5.6 -0.3 4.45e-8 Palmitoleic acid (16:1n-7) levels; CRC trans rs12432203 1.000 rs9918 chr14:51722690 T/C cg14592830 chr9:122318704 NA 0.61 6.19 0.32 1.78e-9 Cancer; CRC cis rs6448317 0.906 rs4053966 chr4:24901466 A/G cg21108841 chr4:24914750 CCDC149 -0.41 -5.72 -0.3 2.45e-8 Heschl's gyrus morphology; CRC cis rs12079745 0.793 rs12092506 chr1:169405517 A/G cg09363564 chr1:169337483 NME7;BLZF1 -0.9 -6.06 -0.32 3.76e-9 QT interval; CRC cis rs4731207 0.596 rs1026837 chr7:124673079 C/T cg23710748 chr7:124431027 NA -0.43 -6.72 -0.35 8e-11 Cutaneous malignant melanoma; CRC cis rs7945705 0.747 rs1980428 chr11:9010497 A/G cg00186954 chr11:8933980 ST5;C11orf17 0.46 7.78 0.39 9.67e-14 Hemoglobin concentration; CRC cis rs989128 0.600 rs739924 chr17:48631607 T/C cg16068336 chr17:48637367 CACNA1G -0.48 -6.94 -0.36 2.11e-11 Type 2 diabetes; CRC cis rs270601 0.913 rs273916 chr5:131659830 C/A cg02033258 chr5:131593261 PDLIM4 0.38 6.24 0.33 1.37e-9 Acylcarnitine levels; CRC cis rs9322193 0.923 rs17745062 chr6:150042215 T/A cg13206674 chr6:150067644 NUP43 0.65 9.75 0.47 6.68e-20 Lung cancer; CRC cis rs10504229 0.683 rs72649192 chr8:58110490 T/C cg02725872 chr8:58115012 NA -0.58 -8.44 -0.42 9.93e-16 Developmental language disorder (linguistic errors); CRC cis rs751728 0.965 rs9394168 chr6:33759701 T/A cg25922239 chr6:33757077 LEMD2 0.62 9.49 0.46 4.83e-19 Crohn's disease; CRC cis rs72634258 0.572 rs66692705 chr1:7938565 T/C cg26816564 chr1:7831052 VAMP3 0.77 8.57 0.43 4.09e-16 Inflammatory bowel disease; CRC cis rs965469 0.895 rs6051843 chr20:3400538 A/G cg25506879 chr20:3388711 C20orf194 -0.41 -6.36 -0.33 6.56e-10 IFN-related cytopenia; CRC cis rs2032447 0.507 rs478349 chr6:25894057 T/C cg03517284 chr6:25882590 NA -0.8 -11.14 -0.52 1.15e-24 Intelligence (multi-trait analysis); CRC cis rs3889199 0.924 rs7517356 chr1:59679122 G/A cg25881383 chr1:59680599 NA -0.38 -6.19 -0.32 1.8e-9 Pulse pressure; CRC cis rs8060686 0.641 rs12445396 chr16:68155121 G/A cg26727032 chr16:67993705 SLC12A4 -0.55 -6.3 -0.33 9.82e-10 HDL cholesterol;Metabolic syndrome; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg08400563 chr2:201729555 CLK1 0.5 6.35 0.33 7.34e-10 Thyroid stimulating hormone; CRC cis rs9372498 0.536 rs62424175 chr6:118797381 T/A cg01339444 chr6:118972232 C6orf204 0.55 6.01 0.31 4.93e-9 Diastolic blood pressure; CRC cis rs6502050 0.799 rs6502078 chr17:80124364 G/A cg13198984 chr17:80129470 CCDC57 0.47 8.35 0.42 1.88e-15 Life satisfaction; CRC cis rs875971 1.000 rs7789768 chr7:65938980 A/C cg00343986 chr7:65444356 GUSB 0.43 6.29 0.33 1.03e-9 Aortic root size; CRC cis rs13082711 0.911 rs11716531 chr3:27457208 G/A cg02860705 chr3:27208620 NA 0.6 8.45 0.42 9.64e-16 Systolic blood pressure;Diastolic blood pressure;Blood pressure; CRC cis rs2839186 0.526 rs59977673 chr21:47922091 C/T cg13012494 chr21:47604986 C21orf56 0.41 6.27 0.33 1.11e-9 Testicular germ cell tumor; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg16347724 chr6:27782484 HIST1H2AJ;HIST1H2BM 0.43 6.43 0.33 4.47e-10 Liver disease severity in Alagille syndrome; CRC cis rs12216125 0.554 rs6942196 chr6:26072804 A/G cg17691542 chr6:26056736 HIST1H1C 0.56 8.53 0.43 5.25e-16 Iron status biomarkers; CRC cis rs6570726 0.811 rs375873 chr6:145812371 G/T cg23711669 chr6:146136114 FBXO30 0.62 10.58 0.5 9.97e-23 Lobe attachment (rater-scored or self-reported); CRC cis rs801193 0.569 rs881285 chr7:66119420 A/G cg11764359 chr7:65958608 NA -0.59 -8.69 -0.43 1.7e-16 Aortic root size; CRC cis rs7107174 0.892 rs2510031 chr11:77969956 T/C cg02023728 chr11:77925099 USP35 0.52 8.9 0.44 3.89e-17 Testicular germ cell tumor; CRC cis rs11227306 0.934 rs2303384 chr11:65640204 C/T cg26695010 chr11:65641043 EFEMP2 0.44 6.28 0.33 1.05e-9 DNA methylation (variation); CRC trans rs8002861 0.935 rs1819595 chr13:44429716 T/A cg17145862 chr1:211918768 LPGAT1 0.75 15.17 0.64 9.02e-40 Leprosy; CRC cis rs6088580 0.634 rs6120666 chr20:33090718 A/G cg08999081 chr20:33150536 PIGU 0.62 11.29 0.53 3.3e-25 Glomerular filtration rate (creatinine); CRC cis rs709400 0.827 rs2274269 chr14:104029246 G/A cg01849466 chr14:104193079 ZFYVE21 0.38 6.03 0.32 4.3e-9 Body mass index; CRC cis rs7781266 0.895 rs6956399 chr7:133305729 G/A cg03336402 chr7:133662267 EXOC4 0.49 6.02 0.31 4.77e-9 Educational attainment (college completion); CRC cis rs3791556 0.504 rs1001285 chr2:240107814 A/G cg03281426 chr2:240109471 HDAC4 0.9 16.66 0.68 1.25e-45 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs3857536 0.813 rs7766786 chr6:66932889 C/A cg07460842 chr6:66804631 NA -0.42 -5.62 -0.3 4.11e-8 Blood trace element (Cu levels); CRC cis rs1953600 0.870 rs2573370 chr10:81951366 C/T cg04850286 chr10:81895943 PLAC9 0.37 6.71 0.35 8.44e-11 Sarcoidosis; CRC cis rs17253792 0.822 rs75936910 chr14:56149351 T/C cg01858014 chr14:56050164 KTN1 -0.88 -7.22 -0.37 3.55e-12 Putamen volume; CRC cis rs208520 1.000 rs208535 chr6:66962286 G/A cg07460842 chr6:66804631 NA -0.92 -11.45 -0.53 8.97e-26 Exhaled nitric oxide output; CRC cis rs6502050 0.835 rs3924780 chr17:80112978 G/A cg13198984 chr17:80129470 CCDC57 0.46 8.16 0.41 6.94e-15 Life satisfaction; CRC cis rs12594515 1.000 rs6493168 chr15:45986811 A/C cg06207120 chr15:45996521 NA 0.32 7.85 0.4 6.04e-14 Waist circumference;Weight; CRC cis rs3785574 0.962 rs58131426 chr17:61854375 T/C cg23090583 chr17:61904693 PSMC5;FTSJ3 0.66 9.6 0.47 2.15e-19 Height; CRC cis rs2032447 0.714 rs175319 chr6:25956172 A/G cg18357526 chr6:26021779 HIST1H4A 0.72 10.64 0.51 6.49e-23 Intelligence (multi-trait analysis); CRC trans rs9868809 0.881 rs2276852 chr3:48666923 A/G cg03060546 chr3:49711283 APEH -0.52 -6.04 -0.32 4.06e-9 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; CRC cis rs7827545 1.000 rs6578237 chr8:135569358 C/G cg17885191 chr8:135476712 NA -0.45 -6.51 -0.34 2.78e-10 Hypertension (SNP x SNP interaction); CRC cis rs4862750 0.957 rs6858853 chr4:187903412 A/C cg03647317 chr4:187891568 NA 0.54 9.85 0.48 3.17e-20 Lobe attachment (rater-scored or self-reported); CRC cis rs7772486 0.597 rs2246132 chr6:146182515 C/G cg13319975 chr6:146136371 FBXO30 -0.63 -9.1 -0.45 8.6e-18 Lobe attachment (rater-scored or self-reported); CRC cis rs28386778 1.000 rs3020613 chr17:61955983 A/G cg23090583 chr17:61904693 PSMC5;FTSJ3 1.01 19.01 0.72 6.94e-55 Prudent dietary pattern; CRC cis rs13191362 1.000 rs34052221 chr6:163160803 G/A cg21926612 chr6:163149169 PACRG;PARK2 0.98 12.81 0.58 9.35e-31 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs28386778 0.863 rs11649912 chr17:61797515 T/A cg25654072 chr17:61904446 PSMC5;FTSJ3 0.7 10.94 0.52 5.88e-24 Prudent dietary pattern; CRC cis rs2404602 0.608 rs17361504 chr15:76601871 A/G cg22467129 chr15:76604101 ETFA -0.44 -7.83 -0.4 6.77e-14 Blood metabolite levels; CRC cis rs380904 1.000 rs12543128 chr8:144595042 G/A cg20583945 chr8:144636462 GSDMD 0.5 7.09 0.36 8.22e-12 Venous thromboembolism (SNP x SNP interaction); CRC cis rs55794721 0.509 rs11249248 chr1:25753051 T/C cg27572855 chr1:25598939 RHD 0.34 6.07 0.32 3.47e-9 Plateletcrit;Mean corpuscular volume; CRC cis rs1862618 0.853 rs252919 chr5:56124111 T/C cg22800045 chr5:56110881 MAP3K1 0.55 6.11 0.32 2.86e-9 Initial pursuit acceleration; CRC cis rs2404602 0.583 rs12438741 chr15:76542114 C/A cg00316803 chr15:76480434 C15orf27 -0.38 -6.38 -0.33 5.94e-10 Blood metabolite levels; CRC cis rs9292777 0.666 rs55673407 chr5:40399074 T/A cg09067459 chr5:40385259 NA -0.55 -8.97 -0.44 2.31e-17 Crohn's disease;Multiple sclerosis; CRC cis rs1524976 1.000 rs62255277 chr3:65470507 A/G cg16238336 chr3:65465873 MAGI1 -0.54 -7.63 -0.39 2.6e-13 PR interval; CRC cis rs10911232 0.507 rs4369195 chr1:182996291 G/C ch.1.3577855R chr1:183094577 LAMC1 0.87 15.19 0.64 7.56e-40 Hypertriglyceridemia; CRC trans rs1997103 1.000 rs6948112 chr7:55411302 G/A cg20935933 chr6:143382018 AIG1 0.51 6.65 0.34 1.25e-10 QRS interval (sulfonylurea treatment interaction); CRC cis rs7474896 0.583 rs12783272 chr10:38024885 T/G cg25427524 chr10:38739819 LOC399744 -0.61 -7.38 -0.38 1.34e-12 Obesity (extreme); CRC cis rs561341 1.000 rs560132 chr17:30320019 C/T cg19193384 chr17:30244184 NA -0.63 -7.4 -0.38 1.15e-12 Hip circumference adjusted for BMI; CRC cis rs9388451 0.839 rs9401845 chr6:126104118 A/G cg05901451 chr6:126070800 HEY2 -0.65 -11.17 -0.52 8.86e-25 Brugada syndrome; CRC cis rs7258465 1.000 rs3810429 chr19:18543270 G/T cg06462663 chr19:18546047 ISYNA1 0.5 7.37 0.38 1.38e-12 Breast cancer; CRC cis rs4964805 0.626 rs869993 chr12:104175138 A/T cg02344784 chr12:104178138 NT5DC3 0.57 8.77 0.44 9.48e-17 Attention deficit hyperactivity disorder; CRC cis rs6951245 0.938 rs112425403 chr7:1071531 A/G cg04025307 chr7:1156635 C7orf50 0.63 6.61 0.34 1.53e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs4481887 0.861 rs7412034 chr1:248434150 G/C cg00666640 chr1:248458726 OR2T12 0.5 8.89 0.44 4.04e-17 Common traits (Other); CRC cis rs7512552 0.839 rs11587575 chr1:150451863 T/C cg15654264 chr1:150340011 RPRD2 0.6 8.33 0.42 2.15e-15 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); CRC cis rs7626444 0.625 rs2686593 chr3:196477401 G/A cg12930392 chr3:196481615 PAK2 0.41 7.3 0.37 2.23e-12 Monocyte count; CRC trans rs17685 0.753 rs7804598 chr7:75702578 C/T cg19862616 chr7:65841803 NCRNA00174 0.98 18.14 0.71 1.77e-51 Coffee consumption;Coffee consumption (cups per day); CRC cis rs1552244 1.000 rs17032283 chr3:10081545 C/G cg16606324 chr3:10149918 C3orf24 0.73 9.73 0.47 8.13e-20 Alzheimer's disease; CRC cis rs1218582 0.772 rs6683557 chr1:154852307 C/G cg16680214 chr1:154839983 KCNN3 -0.48 -9.66 -0.47 1.33e-19 Prostate cancer; CRC cis rs13191362 1.000 rs67747005 chr6:163150845 G/A cg23758597 chr6:163146217 PARK2 -0.57 -6.35 -0.33 7.21e-10 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs589448 0.867 rs623853 chr12:69753830 G/A cg14784868 chr12:69753453 YEATS4 0.91 17.62 0.7 2.07e-49 Cerebrospinal fluid biomarker levels; CRC cis rs7811142 0.830 rs6948685 chr7:99970188 C/T cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.74 9.93 0.48 1.73e-20 Platelet count; CRC trans rs3942852 0.869 rs4752806 chr11:48118199 G/C cg15704280 chr7:45808275 SEPT13 -0.56 -6.95 -0.36 1.95e-11 Acute lymphoblastic leukemia (childhood); CRC cis rs61776719 0.520 rs12569027 chr1:38449163 C/T cg04673462 chr1:38461896 NA 0.35 5.72 0.3 2.35e-8 Coronary artery disease; CRC cis rs1552244 0.554 rs13081079 chr3:10056348 A/G cg00166722 chr3:10149974 C3orf24 0.43 6.32 0.33 8.43e-10 Alzheimer's disease; CRC cis rs7086627 0.515 rs10887895 chr10:82210011 A/G cg09626299 chr10:82213104 TSPAN14 -0.37 -6.23 -0.33 1.39e-9 Post bronchodilator FEV1; CRC cis rs11971779 0.555 rs6950143 chr7:139054418 C/T cg07862535 chr7:139043722 LUC7L2 0.57 7.35 0.38 1.61e-12 Diisocyanate-induced asthma; CRC cis rs10911251 0.528 rs4652777 chr1:183091992 T/G ch.1.3577855R chr1:183094577 LAMC1 0.89 15.86 0.66 1.84e-42 Colorectal cancer; CRC cis rs11229555 0.645 rs7929868 chr11:58209418 C/T cg15696309 chr11:58395628 NA -0.82 -10.45 -0.5 2.81e-22 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; CRC cis rs4332037 0.624 rs73046339 chr7:1889300 G/A cg21155852 chr7:2048760 MAD1L1 -0.42 -6.14 -0.32 2.32e-9 Bipolar disorder; CRC cis rs9611565 0.592 rs5758427 chr22:42099688 A/G cg06634786 chr22:41940651 POLR3H 0.59 6.93 0.36 2.24e-11 Vitiligo; CRC cis rs7493 1.000 rs3779492 chr7:95044183 C/T cg20119798 chr7:94954144 PON1 -0.49 -6.26 -0.33 1.21e-9 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs9900062 0.507 rs7225993 chr17:62708284 C/G cg02097616 chr17:62675921 NA 0.45 6.68 0.35 1.05e-10 QT interval; CRC cis rs6088580 0.634 rs6120644 chr20:33023810 G/A cg08999081 chr20:33150536 PIGU 0.61 11.57 0.54 3.44e-26 Glomerular filtration rate (creatinine); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg27438756 chr1:74663921 TNNI3K;FPGT;LRRIQ3 0.38 6.12 0.32 2.6e-9 Liver disease severity in Alagille syndrome; CRC cis rs9926296 0.529 rs7195906 chr16:89806347 A/T cg21285383 chr16:89894308 SPIRE2 0.35 5.84 0.31 1.25e-8 Vitiligo; CRC cis rs877282 0.583 rs11253429 chr10:823234 A/C cg17470449 chr10:769945 NA 0.51 7.05 0.36 1.03e-11 Uric acid levels; CRC cis rs11645898 0.748 rs72787056 chr16:72099694 C/T cg14768367 chr16:72042858 DHODH -0.72 -7.35 -0.38 1.59e-12 Blood protein levels; CRC cis rs2304069 0.545 rs11167492 chr5:149403101 G/A cg22760475 chr5:149380129 HMGXB3;TIGD6 0.46 6.77 0.35 5.83e-11 HIV-1 control; CRC cis rs4713118 0.513 rs149942 chr6:28001610 T/C cg21251018 chr6:28226885 NKAPL 0.48 7.51 0.38 5.5e-13 Parkinson's disease; CRC cis rs1451375 0.698 rs11489736 chr7:50645372 G/A cg14593290 chr7:50529359 DDC 0.51 7.11 0.37 7.09e-12 Malaria; CRC cis rs853679 1.000 rs10456362 chr6:28221816 A/G cg06470822 chr6:28175283 NA -0.62 -6.5 -0.34 3.01e-10 Depression; CRC cis rs7587476 0.784 rs34112702 chr2:215696002 A/G cg04004882 chr2:215674386 BARD1 0.66 9.21 0.45 4.08e-18 Neuroblastoma; CRC cis rs4713118 0.662 rs149948 chr6:27974817 C/G cg06470822 chr6:28175283 NA 0.85 12.72 0.57 2.03e-30 Parkinson's disease; CRC trans rs951252 0.504 rs11734405 chr4:146081096 C/T cg20809690 chr4:2757764 TNIP2 0.46 6.12 0.32 2.73e-9 Hip circumference; CRC cis rs644148 0.967 rs2686778 chr19:44972257 G/A cg15540054 chr19:45004280 ZNF180 -0.69 -9.76 -0.47 6.24e-20 Personality dimensions; CRC cis rs9291683 0.546 rs12504565 chr4:10045145 G/A cg11266682 chr4:10021025 SLC2A9 0.52 10.62 0.51 7.35e-23 Bone mineral density; CRC cis rs28830936 0.966 rs1107858 chr15:41968226 G/A cg17847044 chr15:42102381 MAPKBP1 -0.3 -6.18 -0.32 1.89e-9 Diastolic blood pressure; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg01657694 chr22:20849950 KLHL22 0.47 6.19 0.32 1.83e-9 Anxiety disorder; CRC cis rs7385804 0.796 rs2432930 chr7:100299024 A/G cg20848291 chr7:100343083 ZAN 0.5 7.76 0.39 1.11e-13 Iron status biomarkers;Mean corpuscular hemoglobin;Hematocrit;Iron status biomarkers (transferrin saturation);Red blood cell count;Iron status biomarkers (iron levels);Mean corpuscular volume;Hematological parameters; CRC cis rs2576037 0.526 rs2051292 chr18:44484372 C/G cg19077165 chr18:44547161 KATNAL2 -0.56 -8.88 -0.44 4.58e-17 Personality dimensions; CRC cis rs10901296 0.660 rs2855198 chr9:133764606 T/C cg01000188 chr9:133769184 QRFP 0.62 7.82 0.4 7.42e-14 Bilirubin levels; CRC cis rs3018066 0.836 rs3109955 chr4:107254171 T/C cg01869342 chr4:106983673 TBCK 0.36 5.61 0.3 4.25e-8 Cancer; CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg17156767 chr19:30364462 NA 0.38 6.12 0.32 2.69e-9 Obesity-related traits; CRC cis rs7927592 0.913 rs7123564 chr11:68362164 C/T cg16797656 chr11:68205561 LRP5 0.37 5.74 0.3 2.16e-8 Total body bone mineral density; CRC cis rs8078723 0.933 rs4794822 chr17:38156712 C/T cg17467752 chr17:38218738 THRA 0.73 11.8 0.55 4.95e-27 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg20150972 chr6:13574573 SIRT5 0.41 7.09 0.36 8.45e-12 Liver disease severity in Alagille syndrome; CRC cis rs270601 0.770 rs932019 chr5:131599370 T/C cg22638593 chr5:131593259 PDLIM4 0.49 9.27 0.45 2.59e-18 Acylcarnitine levels; CRC cis rs3731570 0.818 rs66730758 chr2:198341001 A/G cg10820045 chr2:198174542 NA 0.33 5.88 0.31 9.94e-9 Morning vs. evening chronotype; CRC cis rs7647973 0.626 rs1078341 chr3:49685592 A/G cg03060546 chr3:49711283 APEH 0.64 7.98 0.4 2.41e-14 Menarche (age at onset); CRC cis rs473651 0.935 rs483166 chr2:239346641 C/T cg18131467 chr2:239335373 ASB1 -1.03 -22.68 -0.78 3.24e-69 Multiple system atrophy; CRC cis rs9400271 0.632 rs9374070 chr6:109586455 G/A cg01475377 chr6:109611718 NA -0.37 -6.29 -0.33 1e-9 Sum neutrophil eosinophil counts;Sum basophil neutrophil counts;White blood cell count;Neutrophil count;Myeloid white cell count;Granulocyte count; CRC cis rs514406 0.644 rs6661196 chr1:53203664 A/G cg24675658 chr1:53192096 ZYG11B 0.72 11.71 0.54 1.02e-26 Monocyte count; CRC cis rs6696846 0.715 rs61822659 chr1:205142847 G/A cg00857998 chr1:205179979 DSTYK 0.49 6.57 0.34 1.95e-10 Red blood cell count; CRC cis rs7493 0.950 rs17166868 chr7:95033416 C/T cg07404485 chr7:94953653 PON1 -0.47 -6.24 -0.33 1.37e-9 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs9486719 0.690 rs2092094 chr6:96844123 G/C cg06623918 chr6:96969491 KIAA0776 0.79 8.57 0.43 4.23e-16 Migraine;Coronary artery disease; CRC trans rs559356 0.519 rs475330 chr3:34841244 A/G cg19071035 chr6:20404090 E2F3 -0.45 -6.08 -0.32 3.38e-9 Cognitive function; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg05513509 chr18:20513742 RBBP8 0.43 6.95 0.36 1.95e-11 Liver disease severity in Alagille syndrome; CRC cis rs6121246 0.559 rs1484994 chr20:30305975 A/G cg13852791 chr20:30311386 BCL2L1 0.73 13.81 0.61 1.58e-34 Mean corpuscular hemoglobin; CRC cis rs875971 0.545 rs73378304 chr7:65640747 G/A cg18876405 chr7:65276391 NA 0.44 6.42 0.33 4.69e-10 Aortic root size; CRC cis rs9325144 0.554 rs1906264 chr12:38739490 A/G cg13010199 chr12:38710504 ALG10B 0.39 5.8 0.3 1.57e-8 Morning vs. evening chronotype; CRC cis rs79349575 0.870 rs12941262 chr17:46967037 T/A cg00947319 chr17:47005597 UBE2Z -0.34 -5.92 -0.31 8.16e-9 Type 2 diabetes; CRC cis rs13108904 0.539 rs13140926 chr4:1340939 G/A cg20092199 chr4:1342459 KIAA1530 0.46 7.25 0.37 3.06e-12 Obesity-related traits; CRC cis rs875971 0.540 rs1723268 chr7:65473080 A/C cg18876405 chr7:65276391 NA 0.67 12.14 0.56 2.73e-28 Aortic root size; CRC cis rs3862260 0.509 rs3795662 chr1:120165135 G/T cg11530693 chr1:120165357 ZNF697 0.61 9.64 0.47 1.54e-19 Systemic lupus erythematosus; CRC cis rs7614311 0.731 rs3733121 chr3:63850660 C/G cg22134162 chr3:63841271 THOC7 -0.58 -5.86 -0.31 1.1e-8 Lung function (FVC);Lung function (FEV1); CRC cis rs758324 1.000 rs758324 chr5:131109545 G/T cg06307176 chr5:131281290 NA 0.43 6.38 0.33 6.19e-10 Alzheimer's disease in APOE e4- carriers; CRC cis rs7584330 0.780 rs10176842 chr2:238428256 T/C cg16989719 chr2:238392110 NA -0.38 -7.43 -0.38 9.71e-13 Prostate cancer; CRC cis rs344364 0.511 rs2982455 chr16:1950498 T/G cg00046913 chr16:1877150 HAGH;FAHD1 -0.57 -5.98 -0.31 5.7e-9 Glomerular filtration rate in chronic kidney disease; CRC cis rs7772486 0.558 rs9376965 chr6:146130055 G/A cg13319975 chr6:146136371 FBXO30 -0.63 -9.05 -0.45 1.3e-17 Lobe attachment (rater-scored or self-reported); CRC cis rs11098499 0.955 rs7685268 chr4:120162188 G/A cg24375607 chr4:120327624 NA 0.43 6.69 0.35 9.56e-11 Corneal astigmatism; CRC cis rs6500395 1.000 rs7196823 chr16:48616278 G/A cg04672837 chr16:48644449 N4BP1 0.44 6.6 0.34 1.69e-10 Response to tocilizumab in rheumatoid arthritis; CRC cis rs4523957 0.928 rs216179 chr17:2168878 T/A cg16513277 chr17:2031491 SMG6 0.56 9.54 0.47 3.26e-19 Autism spectrum disorder or schizophrenia;Schizophrenia; CRC cis rs7769051 0.803 rs56148066 chr6:133230115 G/A cg07930552 chr6:133119739 C6orf192 0.57 6.5 0.34 2.9e-10 Type 2 diabetes nephropathy; CRC cis rs6964587 0.620 rs6967588 chr7:91643402 G/T cg17063962 chr7:91808500 NA 0.62 10.01 0.48 9.42e-21 Breast cancer; CRC cis rs6963495 1.000 rs6963495 chr7:105166853 T/C cg13798780 chr7:105162888 PUS7 0.6 6.04 0.32 4.25e-9 Bipolar disorder (body mass index interaction); CRC cis rs367943 1.000 rs348946 chr5:112822814 C/T cg12552261 chr5:112820674 MCC -0.49 -7.52 -0.38 5.23e-13 Type 2 diabetes; CRC cis rs896854 0.846 rs2340584 chr8:95916811 A/G cg09323728 chr8:95962352 TP53INP1 -0.4 -6.41 -0.33 5.11e-10 Type 2 diabetes; CRC cis rs7809950 0.678 rs2301801 chr7:106870746 T/C cg23024343 chr7:107201750 COG5 -0.72 -9.56 -0.47 2.93e-19 Coronary artery disease; CRC cis rs10097731 0.808 rs80141261 chr8:82034453 T/C cg25230327 chr8:82042993 NA -0.81 -12.04 -0.55 6.59e-28 Serum total protein level; CRC cis rs6728302 0.557 rs73002000 chr2:233254052 C/T cg09490371 chr2:233253024 ECEL1P2 -0.72 -6.38 -0.33 5.88e-10 Height; CRC cis rs1046896 0.594 rs4075209 chr17:80800027 G/T cg16060761 chr17:80687452 NA -0.46 -5.9 -0.31 9.22e-9 Glycated hemoglobin levels; CRC cis rs34172651 0.917 rs200529 chr16:24758502 T/C cg06505273 chr16:24850292 NA -0.39 -5.95 -0.31 6.75e-9 Intelligence (multi-trait analysis); CRC cis rs12545109 0.800 rs990301 chr8:57406021 G/C cg09654669 chr8:57350985 NA -0.47 -7.57 -0.39 3.75e-13 Obesity-related traits; CRC cis rs2976388 0.609 rs2244152 chr8:143784885 C/A cg20041105 chr8:143859282 LYNX1 0.46 8.15 0.41 7.63e-15 Urinary tract infection frequency; CRC cis rs10504229 0.683 rs55986917 chr8:58137210 C/T cg24829409 chr8:58192753 C8orf71 -0.55 -8.03 -0.4 1.71e-14 Developmental language disorder (linguistic errors); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg04044502 chr10:64028395 RTKN2 0.45 6.39 0.33 5.52e-10 Response to antipsychotic treatment; CRC cis rs2576037 0.501 rs8089938 chr18:44459497 C/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.51 8.11 0.41 1.02e-14 Personality dimensions; CRC cis rs2463822 0.669 rs72919480 chr11:62043133 G/A cg06239285 chr11:62104954 ASRGL1 -0.86 -8.53 -0.43 5.46e-16 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs8060686 0.641 rs7204192 chr16:68039309 A/G cg26727032 chr16:67993705 SLC12A4 -0.59 -7.97 -0.4 2.6e-14 HDL cholesterol;Metabolic syndrome; CRC cis rs2976388 0.556 rs4736300 chr8:143829269 C/T cg22687807 chr8:143858763 LYNX1 -0.45 -7.05 -0.36 1.08e-11 Urinary tract infection frequency; CRC trans rs9929218 0.559 rs12923775 chr16:68756450 C/T cg04657470 chr2:198365150 HSPE1;HSPD1 0.97 18.16 0.71 1.55e-51 Colorectal cancer; CRC cis rs4731207 0.651 rs1525619 chr7:124654541 T/A cg23710748 chr7:124431027 NA -0.39 -6.25 -0.33 1.24e-9 Cutaneous malignant melanoma; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg20288518 chr10:71389959 C10orf35 0.41 6.39 0.33 5.54e-10 Liver disease severity in Alagille syndrome; CRC cis rs12286929 0.606 rs11823428 chr11:115071222 C/A cg04055981 chr11:115044050 NA 0.43 6.87 0.35 3.3e-11 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs2404602 0.622 rs1567671 chr15:77209200 C/G cg23625390 chr15:77176239 SCAPER -0.85 -12.04 -0.55 6.36e-28 Blood metabolite levels; CRC trans rs7976838 0.908 rs12826693 chr12:60155471 A/G cg16974014 chr22:22007515 MIR130B 0.52 6.17 0.32 2e-9 Response to zileuton treatment in asthma (FEV1 change interaction); CRC cis rs172166 0.694 rs536704 chr6:28092603 T/G cg17949981 chr6:28129498 ZNF389 0.42 5.81 0.3 1.51e-8 Cardiac Troponin-T levels; CRC cis rs1451375 0.698 rs68143668 chr7:50638110 C/T cg18232548 chr7:50535776 DDC 0.43 6.1 0.32 2.93e-9 Malaria; CRC cis rs477895 0.713 rs35095324 chr11:63948412 G/A cg04317338 chr11:64019027 PLCB3 0.6 7.41 0.38 1.08e-12 Mean platelet volume; CRC cis rs9311474 0.508 rs7652191 chr3:52610415 T/C cg18404041 chr3:52824283 ITIH1 -0.4 -8.45 -0.42 9.79e-16 Electroencephalogram traits; CRC trans rs1005277 0.505 rs10827836 chr10:38215441 A/G cg27523141 chr10:43048294 ZNF37B -0.45 -6.42 -0.33 4.74e-10 Extrinsic epigenetic age acceleration; CRC cis rs933688 1.000 rs6862125 chr5:90724598 T/C cg02339078 chr5:90679543 LOC100129716;ARRDC3 0.95 15.21 0.64 6.36e-40 Smoking behavior; CRC cis rs1018836 0.923 rs6986088 chr8:91538474 A/C cg16814680 chr8:91681699 NA -0.71 -11.85 -0.55 3.1e-27 Ejection fraction in Tripanosoma cruzi seropositivity; CRC cis rs1950626 0.833 rs67456801 chr14:101399169 C/T cg02351406 chr14:101447389 SNORD114-20;SNORD114-21 0.95 15.91 0.66 1.13e-42 Pelvic organ prolapse (moderate/severe); CRC cis rs1552244 0.554 rs3732963 chr3:10048885 G/T cg08888203 chr3:10149979 C3orf24 0.48 7.33 0.37 1.74e-12 Alzheimer's disease; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg13476336 chr17:38255694 NR1D1 0.47 6.51 0.34 2.86e-10 Response to antipsychotic treatment; CRC cis rs453301 0.686 rs7017868 chr8:8873293 G/A cg14979609 chr8:8086686 FLJ10661 0.38 6.14 0.32 2.44e-9 Joint mobility (Beighton score); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg27018124 chr22:26879714 HPS4;SRRD 0.47 6.83 0.35 4.24e-11 Response to antipsychotic treatment; CRC cis rs1018836 0.892 rs10105142 chr8:91547420 C/T cg16814680 chr8:91681699 NA -0.65 -10.27 -0.49 1.19e-21 Ejection fraction in Tripanosoma cruzi seropositivity; CRC cis rs9322817 0.691 rs2486141 chr6:105299930 G/A cg02098413 chr6:105308735 HACE1 0.43 8.51 0.42 6.41e-16 Thyroid stimulating hormone; CRC trans rs6703335 0.870 rs10803142 chr1:243598234 A/G cg16131300 chr5:31532187 RNASEN;C5orf22 0.49 6.89 0.36 2.89e-11 Schizophrenia;Schizophrenia, schizoaffective disorder or bipolar disorder; CRC cis rs7119 0.604 rs2271398 chr15:77907784 G/A cg10437265 chr15:77819839 NA -0.45 -8.06 -0.41 1.43e-14 Type 2 diabetes; CRC cis rs9903692 0.779 rs2285863 chr17:46125978 C/G cg21215337 chr17:46176117 CBX1 0.42 7.77 0.39 9.91e-14 Pulse pressure; CRC cis rs6570726 0.791 rs6570693 chr6:145910841 C/T cg13319975 chr6:146136371 FBXO30 -0.44 -6.44 -0.33 4.17e-10 Lobe attachment (rater-scored or self-reported); CRC cis rs7666738 0.830 rs13137859 chr4:99050319 A/G cg17366294 chr4:99064904 C4orf37 0.45 7.75 0.39 1.16e-13 Colonoscopy-negative controls vs population controls; CRC cis rs4237845 0.816 rs61935769 chr12:58294344 G/A cg02175503 chr12:58329896 NA 0.55 7.08 0.36 8.98e-12 Intelligence (multi-trait analysis); CRC cis rs12946454 0.621 rs11651809 chr17:43255681 C/G cg10701640 chr17:43249399 NA 0.49 11.42 0.53 1.12e-25 Systolic blood pressure; CRC trans rs561341 1.000 rs550923 chr17:30327013 G/C cg20587970 chr11:113659929 NA -1.43 -20.38 -0.75 2.82e-60 Hip circumference adjusted for BMI; CRC cis rs7605827 0.930 rs1861768 chr2:15625186 C/A cg19274914 chr2:15703543 NA 0.39 5.95 0.31 6.89e-9 Educational attainment (years of education); CRC cis rs11098499 0.909 rs9759478 chr4:120367998 G/A cg09307838 chr4:120376055 NA 0.71 10.74 0.51 2.92e-23 Corneal astigmatism; CRC cis rs9649213 0.593 rs3801255 chr7:98000929 C/T cg21770322 chr7:97807741 LMTK2 0.52 8.52 0.43 5.7e-16 Prostate cancer (SNP x SNP interaction); CRC cis rs3796352 1.000 rs34313969 chr3:52995166 A/G cg27565382 chr3:53032988 SFMBT1 0.7 6.19 0.32 1.76e-9 Immune reponse to smallpox (secreted IL-2); CRC cis rs6502050 0.637 rs74765203 chr17:80118223 A/G cg22110888 chr17:80059540 CCDC57 0.4 6.37 0.33 6.37e-10 Life satisfaction; CRC cis rs7666738 0.830 rs4699598 chr4:99019158 C/T cg05340658 chr4:99064831 C4orf37 0.61 9.51 0.46 4.05e-19 Colonoscopy-negative controls vs population controls; CRC cis rs72945132 0.709 rs28634008 chr11:70225719 A/C cg00319359 chr11:70116639 PPFIA1 0.55 5.87 0.31 1.08e-8 Coronary artery disease; CRC cis rs2032447 0.714 rs199725 chr6:25953684 A/G cg04800585 chr6:26043546 HIST1H2BB 0.5 7.46 0.38 7.97e-13 Intelligence (multi-trait analysis); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg07591283 chr1:44412003 IPO13 0.43 6.12 0.32 2.67e-9 Response to antipsychotic treatment; CRC cis rs4654899 0.865 rs6426674 chr1:21483906 C/T cg02927042 chr1:21476669 EIF4G3 -0.5 -7.85 -0.4 5.97e-14 Superior frontal gyrus grey matter volume; CRC trans rs1814175 0.645 rs847630 chr11:49926360 C/T cg11707556 chr5:10655725 ANKRD33B -0.52 -9.95 -0.48 1.49e-20 Height; CRC cis rs6502050 0.764 rs35416122 chr17:80119006 A/G cg02741985 chr17:80059408 CCDC57 0.43 7.15 0.37 5.59e-12 Life satisfaction; CRC cis rs854572 0.600 rs705382 chr7:94955221 C/G cg01874867 chr7:94954059 PON1 -0.58 -9.47 -0.46 5.78e-19 Paraoxonase activity; CRC trans rs623264 0.920 rs671283 chr19:5470410 C/G cg13775005 chr14:36002441 INSM2 -0.48 -5.97 -0.31 6.13e-9 Interleukin-2 receptor antagonist levels; CRC cis rs6500395 1.000 rs4517800 chr16:48677404 T/A cg04672837 chr16:48644449 N4BP1 0.45 6.67 0.35 1.09e-10 Response to tocilizumab in rheumatoid arthritis; CRC cis rs12024301 0.557 rs7531786 chr1:183595234 T/C cg11505048 chr1:183622726 RGL1;APOBEC4 0.76 6.93 0.36 2.16e-11 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs9921222 0.632 rs11649268 chr16:398643 A/C cg00101154 chr16:420108 MRPL28 -0.76 -12.59 -0.57 6.38e-30 Bone mineral density (spine);Bone mineral density; CRC cis rs9326248 0.520 rs6589602 chr11:117037065 T/C cg10398005 chr11:117014888 PAFAH1B2 -0.45 -6.72 -0.35 8.03e-11 Blood protein levels; CRC cis rs11098499 0.954 rs10006525 chr4:120408931 T/G cg24375607 chr4:120327624 NA 0.5 7.82 0.4 7.2e-14 Corneal astigmatism; CRC trans rs13046373 0.905 rs4816372 chr21:32077414 A/T cg20755353 chr1:1510883 SSU72 -0.37 -6.17 -0.32 1.98e-9 HDL cholesterol; CRC cis rs798554 0.704 rs709282 chr7:2769921 G/A cg04166393 chr7:2884313 GNA12 0.4 6.09 0.32 3.18e-9 Height; CRC cis rs7618915 0.547 rs62255371 chr3:52747321 A/G cg18099408 chr3:52552593 STAB1 -0.44 -7.24 -0.37 3.28e-12 Bipolar disorder; CRC cis rs1008375 0.966 rs7666888 chr4:17695722 C/T cg16339924 chr4:17578868 LAP3 0.47 6.32 0.33 8.34e-10 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs4563143 0.704 rs16961809 chr19:29226299 C/T cg12756686 chr19:29218302 NA 0.64 10.09 0.49 4.87e-21 Methadone dose in opioid dependence; CRC cis rs45430 1.000 rs416981 chr21:42745414 G/A cg22778903 chr21:42741698 MX2 0.38 6.19 0.32 1.78e-9 Melanoma; CRC cis rs7607369 0.759 rs10179708 chr2:219390967 T/A cg02176678 chr2:219576539 TTLL4 -0.58 -9.17 -0.45 5.43e-18 Red blood cell count;Amyotrophic lateral sclerosis; CRC cis rs2153535 0.601 rs2327054 chr6:8443130 T/C cg07606381 chr6:8435919 SLC35B3 0.68 10.94 0.52 5.78e-24 Motion sickness; CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg21864845 chr1:1208426 UBE2J2 -0.49 -6.03 -0.32 4.41e-9 Diisocyanate-induced asthma; CRC cis rs6942756 1.000 rs67997229 chr7:128957366 G/C cg02491457 chr7:128862824 NA -0.74 -10.05 -0.48 6.67e-21 White matter hyperintensity burden; CRC trans rs3942852 0.955 rs1503190 chr11:48117873 A/G cg15704280 chr7:45808275 SEPT13 -0.56 -6.95 -0.36 1.95e-11 Acute lymphoblastic leukemia (childhood); CRC cis rs4332037 0.539 rs34809719 chr7:2028968 G/T cg23378565 chr7:2036160 MAD1L1 -0.5 -7.03 -0.36 1.17e-11 Bipolar disorder; CRC cis rs10504229 0.679 rs11786328 chr8:58039269 A/G cg24829409 chr8:58192753 C8orf71 -0.58 -7.12 -0.37 6.81e-12 Developmental language disorder (linguistic errors); CRC cis rs4853036 0.857 rs1048139 chr2:70131791 T/A cg02498382 chr2:70120550 SNRNP27 -0.42 -5.96 -0.31 6.66e-9 Colorectal or endometrial cancer; CRC cis rs1707322 0.685 rs56177313 chr1:46225806 A/C cg03146154 chr1:46216737 IPP 0.66 9.44 0.46 7.2e-19 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs938554 0.657 rs7660895 chr4:9985445 A/G cg00071950 chr4:10020882 SLC2A9 0.4 5.87 0.31 1.09e-8 Blood metabolite levels; CRC cis rs6693567 0.545 rs4446975 chr1:150456169 C/T cg15654264 chr1:150340011 RPRD2 0.37 5.65 0.3 3.5e-8 Migraine; CRC cis rs4665809 0.531 rs12987980 chr2:26462093 A/T cg04944784 chr2:26401820 FAM59B 0.85 11.05 0.52 2.29e-24 Gut microbiome composition (summer); CRC trans rs6589563 0.737 rs28927680 chr11:116619073 C/G cg21981096 chr15:96423622 NA 0.54 6.45 0.34 4.09e-10 Eosinophil counts; CRC cis rs208520 0.802 rs208516 chr6:66946119 T/C cg07460842 chr6:66804631 NA -0.96 -12.38 -0.56 3.67e-29 Exhaled nitric oxide output; CRC cis rs6951245 1.000 rs11763835 chr7:1094513 A/G cg22907277 chr7:1156413 C7orf50 0.73 7.7 0.39 1.59e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs4819052 0.851 rs2838850 chr21:46671445 G/C cg02159808 chr21:46707872 POFUT2;LOC642852 0.49 6.51 0.34 2.89e-10 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs67311347 0.955 rs11711994 chr3:40391086 T/C cg09455208 chr3:40491958 NA 0.51 10.1 0.49 4.6e-21 Renal cell carcinoma; CRC cis rs12711979 0.765 rs881852 chr2:3821508 A/G cg17052675 chr2:3827356 NA -0.53 -9.88 -0.48 2.56e-20 Itch intensity from mosquito bite adjusted by bite size; CRC cis rs9487051 0.714 rs7755970 chr6:109602359 A/G cg12927641 chr6:109611667 NA -0.37 -6.52 -0.34 2.68e-10 Reticulocyte fraction of red cells; CRC cis rs1005277 0.579 rs1740742 chr10:38518860 C/T cg03665457 chr10:38645376 HSD17B7P2 -0.42 -5.96 -0.31 6.58e-9 Extrinsic epigenetic age acceleration; CRC trans rs7615952 0.543 rs4645102 chr3:125424441 A/G cg02560186 chr11:3602584 NA -0.63 -9.69 -0.47 1.04e-19 Blood pressure (smoking interaction); CRC cis rs9916302 0.904 rs55660616 chr17:37684990 C/A cg07936489 chr17:37558343 FBXL20 -0.84 -12.9 -0.58 4.26e-31 Glomerular filtration rate (creatinine); CRC cis rs1355223 1.000 rs11607300 chr11:34759319 C/T cg11058730 chr11:34937778 PDHX;APIP -0.45 -6.34 -0.33 7.65e-10 Systemic lupus erythematosus and Systemic sclerosis; CRC cis rs2412819 0.599 rs2470120 chr15:43929070 C/G cg02155558 chr15:43621948 ADAL;LCMT2 0.45 6.09 0.32 3.17e-9 Lung cancer; CRC cis rs9611565 0.694 rs202618 chr22:41822856 A/G cg06481639 chr22:41940642 POLR3H 0.52 5.72 0.3 2.39e-8 Vitiligo; CRC cis rs2439831 0.541 rs12440854 chr15:43610672 A/G cg02155558 chr15:43621948 ADAL;LCMT2 0.8 7.6 0.39 3.15e-13 Lung cancer in ever smokers; CRC cis rs3126085 0.877 rs868304 chr1:152178568 G/A cg09127314 chr1:152161683 NA 0.53 6.69 0.35 9.52e-11 Atopic dermatitis; CRC cis rs225245 0.817 rs225299 chr17:33922742 T/C cg05299278 chr17:33885742 SLFN14 0.48 7.85 0.4 6.03e-14 Reticulocyte count;Reticulocyte fraction of red cells;High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells; CRC cis rs694739 0.930 rs574087 chr11:64102948 A/G cg23796481 chr11:64053134 BAD;GPR137 0.59 8.85 0.44 5.43e-17 Alopecia areata;Crohn's disease;Psoriasis vulgaris; CRC cis rs9462027 0.628 rs3734264 chr6:34831866 G/A cg07306190 chr6:34760872 UHRF1BP1 -0.35 -6.11 -0.32 2.79e-9 Systemic lupus erythematosus; CRC cis rs977987 0.806 rs4888418 chr16:75460306 C/G cg03315344 chr16:75512273 CHST6 0.54 9.15 0.45 6.06e-18 Dupuytren's disease; CRC cis rs7726839 0.794 rs10474792 chr5:600058 G/A cg16447950 chr5:562315 NA -0.56 -8.2 -0.41 5.49e-15 Obesity-related traits; CRC cis rs9814567 1.000 rs3932818 chr3:134206069 A/G cg06541857 chr3:134203789 ANAPC13;CEP63 -0.38 -5.72 -0.3 2.36e-8 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs11577318 0.853 rs17645 chr1:26646730 A/G cg04990556 chr1:26633338 UBXN11 -0.46 -5.76 -0.3 1.98e-8 Granulocyte percentage of myeloid white cells; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg17595410 chr2:128165857 NA 0.48 6.56 0.34 2.09e-10 Anxiety disorder; CRC cis rs853679 0.517 rs9468298 chr6:28122345 A/G cg12273811 chr6:28175739 NA 0.73 9.16 0.45 5.8e-18 Depression; CRC cis rs9399135 0.967 rs12526055 chr6:135325918 C/T cg24558204 chr6:135376177 HBS1L 0.52 8.11 0.41 9.84e-15 Red blood cell count; CRC cis rs7927771 0.864 rs60075622 chr11:47449101 T/G cg20307385 chr11:47447363 PSMC3 -0.62 -9.19 -0.45 4.48e-18 Subjective well-being; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg14021555 chr22:43485536 TTLL1 0.51 6.6 0.34 1.63e-10 Thyroid stimulating hormone; CRC cis rs6088590 1.000 rs10048849 chr20:33419680 C/T cg24642439 chr20:33292090 TP53INP2 0.57 10.01 0.48 8.81e-21 Coronary artery disease; CRC cis rs921968 0.612 rs496908 chr2:219357742 A/T cg02176678 chr2:219576539 TTLL4 0.49 8.1 0.41 1.11e-14 Mean corpuscular hemoglobin concentration; CRC cis rs3785574 0.927 rs2727313 chr17:61961914 A/G cg23090583 chr17:61904693 PSMC5;FTSJ3 0.64 9.21 0.45 3.82e-18 Height; CRC cis rs7666738 0.830 rs10021709 chr4:99030587 G/A cg05340658 chr4:99064831 C4orf37 0.61 9.42 0.46 8.23e-19 Colonoscopy-negative controls vs population controls; CRC cis rs2303759 0.918 rs7251704 chr19:49890873 T/G cg22307029 chr19:49891270 CCDC155 0.66 9.27 0.46 2.54e-18 Multiple sclerosis; CRC cis rs1448094 0.511 rs4462416 chr12:86150966 T/C cg02569458 chr12:86230093 RASSF9 -0.47 -7.98 -0.4 2.46e-14 Major depressive disorder; CRC cis rs2404602 0.684 rs11072602 chr15:76873467 T/C cg03037974 chr15:76606532 NA -0.52 -7.75 -0.39 1.16e-13 Blood metabolite levels; CRC cis rs738322 1.000 rs4381 chr22:38570791 T/C cg25457927 chr22:38595422 NA -0.35 -7.4 -0.38 1.13e-12 Cutaneous nevi; CRC cis rs116095464 0.558 rs10052012 chr5:231908 T/C cg22857025 chr5:266934 NA -1.22 -16.68 -0.68 1.07e-45 Breast cancer; CRC trans rs1005277 0.579 rs116912400 chr10:38479207 G/T cg27523141 chr10:43048294 ZNF37B 0.47 6.74 0.35 7.02e-11 Extrinsic epigenetic age acceleration; CRC cis rs2354432 0.599 rs4950423 chr1:146854539 T/C cg25205988 chr1:146714368 CHD1L 1.16 10.07 0.49 5.68e-21 Mitochondrial DNA levels; CRC cis rs1552244 1.000 rs7622963 chr3:10139825 C/T cg16606324 chr3:10149918 C3orf24 0.69 9.75 0.47 6.97e-20 Alzheimer's disease; CRC cis rs10883723 0.810 rs7093028 chr10:104259417 A/G cg22532475 chr10:104410764 TRIM8 -0.37 -6.86 -0.35 3.51e-11 Allergic disease (asthma, hay fever or eczema); CRC trans rs1656966 1.000 rs1656966 chr3:186466252 C/T cg04219446 chr17:73629082 RECQL5;LOC643008 0.41 6.1 0.32 3.04e-9 Myopia (pathological); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg13445258 chr3:128369860 RPN1 0.47 6.76 0.35 6.3e-11 Response to antipsychotic treatment; CRC cis rs6582630 0.502 rs11610978 chr12:38356957 C/G cg13010199 chr12:38710504 ALG10B 0.47 6.6 0.34 1.64e-10 Drug-induced liver injury (flucloxacillin); CRC cis rs172166 0.694 rs1631552 chr6:28089699 C/A cg10876282 chr6:28092338 ZSCAN16 0.51 6.9 0.36 2.64e-11 Cardiac Troponin-T levels; CRC trans rs12599106 0.560 rs34151874 chr16:34989694 G/A cg21548813 chr6:291882 DUSP22 -0.67 -9.59 -0.47 2.22e-19 Menopause (age at onset); CRC cis rs11098499 0.738 rs28408407 chr4:120376030 C/G cg24375607 chr4:120327624 NA 0.52 7.98 0.4 2.4e-14 Corneal astigmatism; CRC cis rs7589728 0.563 rs12479338 chr2:88444513 C/T cg14558114 chr2:88469736 THNSL2 0.62 6.22 0.32 1.48e-9 Plasma clusterin levels; CRC cis rs9875589 0.957 rs4407395 chr3:13951673 A/G cg19554555 chr3:13937349 NA 0.52 7.45 0.38 8.21e-13 Ovarian reserve; CRC cis rs4474465 0.850 rs4597089 chr11:78262244 A/G cg27205649 chr11:78285834 NARS2 0.51 6.69 0.35 9.79e-11 Alzheimer's disease (survival time); CRC cis rs11971779 0.584 rs17613864 chr7:139095587 C/T cg23387468 chr7:139079360 LUC7L2 0.41 7.05 0.36 1.04e-11 Diisocyanate-induced asthma; CRC cis rs6694672 1.000 rs1576878 chr1:196991325 A/C cg13682187 chr1:196946512 CFHR5 0.59 8.53 0.43 5.57e-16 Asthma; CRC cis rs7618915 0.547 rs11177 chr3:52721305 G/A cg08222913 chr3:52553049 STAB1 -0.34 -6.15 -0.32 2.22e-9 Bipolar disorder; CRC cis rs3764400 0.506 rs72827851 chr17:46452495 C/A cg10706073 chr17:46328419 SKAP1 -0.6 -6.33 -0.33 8.07e-10 Body mass index; CRC cis rs853679 0.517 rs9368558 chr6:28133306 A/G cg12172441 chr6:28176163 NA 0.64 7.53 0.38 5.03e-13 Depression; CRC trans rs2980439 0.846 rs2980437 chr8:8094763 C/T cg16141378 chr3:129829833 LOC729375 0.48 7.37 0.38 1.38e-12 Neuroticism; CRC cis rs2576037 0.583 rs2156049 chr18:44455717 G/A cg19077165 chr18:44547161 KATNAL2 -0.64 -11.11 -0.52 1.44e-24 Personality dimensions; CRC cis rs2075371 1.000 rs1862051 chr7:133981021 G/A cg11752832 chr7:134001865 SLC35B4 0.49 7.56 0.38 4.12e-13 Mean platelet volume; CRC cis rs9372498 0.536 rs62422220 chr6:118923731 G/A cg18833306 chr6:118973337 C6orf204 0.44 5.64 0.3 3.68e-8 Diastolic blood pressure; CRC cis rs9287719 0.967 rs7582775 chr2:10738449 C/T cg00105475 chr2:10696890 NA 0.45 7.3 0.37 2.19e-12 Prostate cancer; CRC cis rs9811920 0.809 rs793476 chr3:99541747 G/T cg07805332 chr3:99536008 MIR548G;C3orf26 0.39 6.03 0.32 4.41e-9 Axial length; CRC cis rs10751667 0.643 rs10902244 chr11:949981 A/G cg01483505 chr11:975446 AP2A2 0.42 6.83 0.35 4.14e-11 Alzheimer's disease (late onset); CRC cis rs4713118 0.715 rs200480 chr6:27773664 A/G cg25164649 chr6:28176230 NA 0.56 7.98 0.4 2.49e-14 Parkinson's disease; CRC cis rs9368481 0.547 rs2093303 chr6:26864406 C/T cg05192639 chr6:26864778 GUSBL1 0.33 5.91 0.31 8.78e-9 Autism spectrum disorder or schizophrenia; CRC cis rs4363385 0.647 rs4845513 chr1:152998066 T/C cg25856811 chr1:152973957 SPRR3 -0.23 -6.39 -0.33 5.76e-10 Inflammatory skin disease; CRC cis rs2976388 1.000 rs1045531 chr8:143763547 C/A cg04969067 chr8:143858791 LYNX1 -0.34 -5.82 -0.31 1.38e-8 Urinary tract infection frequency; CRC cis rs427941 0.550 rs201517 chr7:101769616 G/T cg06246474 chr7:101738831 CUX1 0.37 5.68 0.3 2.97e-8 Plasma omega-3 polyunsaturated fatty acid level (eicosapentaenoic acid); CRC cis rs6662572 0.737 rs4518839 chr1:46376690 G/T cg08644498 chr1:46502608 NA -0.44 -6.85 -0.35 3.69e-11 Blood protein levels; CRC cis rs7086627 0.515 rs10887899 chr10:82210214 G/A cg00277334 chr10:82204260 NA -0.84 -16.84 -0.68 2.56e-46 Post bronchodilator FEV1; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg08841098 chr16:55050401 NA 0.42 6.84 0.35 3.77e-11 Liver disease severity in Alagille syndrome; CRC cis rs34779708 0.931 rs12242882 chr10:35347860 G/C cg03585969 chr10:35415529 CREM 0.6 8.14 0.41 8.07e-15 Inflammatory bowel disease;Crohn's disease; CRC cis rs7945705 0.837 rs2742474 chr11:9002089 A/G cg14711859 chr11:8959438 ASCL3 0.42 7.03 0.36 1.23e-11 Hemoglobin concentration; CRC cis rs9488822 0.676 rs10456902 chr6:116333742 C/G cg15226275 chr6:116381976 FRK -0.29 -8.23 -0.41 4.53e-15 Cholesterol, total;LDL cholesterol; CRC cis rs7666738 0.830 rs34892904 chr4:98938097 T/C cg17366294 chr4:99064904 C4orf37 0.43 7.32 0.37 1.95e-12 Colonoscopy-negative controls vs population controls; CRC cis rs6951245 0.554 rs11761322 chr7:1151657 A/G cg04025307 chr7:1156635 C7orf50 0.66 8.37 0.42 1.67e-15 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs2576037 0.583 rs12386118 chr18:44540376 C/G cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.61 9.98 0.48 1.15e-20 Personality dimensions; CRC cis rs6952808 0.692 rs12666575 chr7:2004421 C/T cg04267008 chr7:1944627 MAD1L1 -0.8 -11.65 -0.54 1.64e-26 Bipolar disorder and schizophrenia; CRC trans rs875971 0.545 rs6979636 chr7:65741625 A/G cg02869306 chr7:64672164 INTS4L1 -0.42 -6.48 -0.34 3.32e-10 Aortic root size; CRC cis rs2404602 0.735 rs11635463 chr15:76762986 C/T cg03037974 chr15:76606532 NA -0.52 -7.5 -0.38 5.99e-13 Blood metabolite levels; CRC cis rs896854 0.654 rs10104909 chr8:95977973 C/T cg16049864 chr8:95962084 TP53INP1 -0.65 -11.74 -0.54 8.01e-27 Type 2 diabetes; CRC trans rs853679 1.000 rs2799077 chr6:28234597 C/T cg06606381 chr12:133084897 FBRSL1 -0.59 -5.99 -0.31 5.55e-9 Depression; CRC cis rs9916302 0.605 rs12938099 chr17:37612910 T/G cg15445000 chr17:37608096 MED1 0.35 6.18 0.32 1.87e-9 Glomerular filtration rate (creatinine); CRC cis rs999943 0.846 rs2274200 chr6:33625696 T/C cg14003231 chr6:33640908 ITPR3 0.94 16.49 0.67 6.22e-45 Obesity (extreme); CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg19250579 chr3:75487529 NA 0.41 6.18 0.32 1.92e-9 Myopia (pathological); CRC cis rs72615157 0.613 rs56089143 chr7:99819844 G/A cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.5 5.95 0.31 6.72e-9 Lung function (FEV1/FVC); CRC cis rs7615952 0.641 rs7640158 chr3:125808011 G/A cg18479299 chr3:125709523 NA -0.56 -6.6 -0.34 1.6e-10 Blood pressure (smoking interaction); CRC trans rs875971 0.545 rs6961853 chr7:66002022 G/A cg02869306 chr7:64672164 INTS4L1 -0.44 -6.39 -0.33 5.78e-10 Aortic root size; CRC cis rs8072100 0.905 rs11651766 chr17:45574931 G/T cg25173405 chr17:45401733 C17orf57 -0.45 -6.89 -0.36 2.87e-11 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC trans rs34787248 1 rs34787248 chr6:28197886 C/T cg06606381 chr12:133084897 FBRSL1 -0.61 -6.33 -0.33 8.13e-10 Autism spectrum disorder or schizophrenia; CRC cis rs6952808 1.000 rs4721121 chr7:1892565 A/G cg22963979 chr7:1858916 MAD1L1 -0.61 -9.51 -0.46 4.24e-19 Bipolar disorder and schizophrenia; CRC trans rs1814175 0.647 rs61306292 chr11:49856040 G/C cg15704280 chr7:45808275 SEPT13 -1.02 -19.98 -0.74 1.06e-58 Height; CRC trans rs10838798 0.504 rs11039634 chr11:48297843 A/G cg21153622 chr11:89784906 NA -0.5 -8.29 -0.42 2.93e-15 Height; CRC cis rs877282 0.947 rs12358875 chr10:757531 T/C cg17470449 chr10:769945 NA 0.64 8.39 0.42 1.42e-15 Uric acid levels; CRC cis rs9487051 0.703 rs351755 chr6:109538073 G/A cg21918786 chr6:109611834 NA 0.37 6.5 0.34 2.95e-10 Reticulocyte fraction of red cells; CRC cis rs7727544 0.716 rs10058655 chr5:131570896 A/T cg12564285 chr5:131593104 PDLIM4 0.4 7.55 0.38 4.43e-13 Blood metabolite levels; CRC cis rs6684514 0.922 rs12022657 chr1:156314147 A/G cg16558208 chr1:156270281 VHLL 0.56 8.71 0.43 1.52e-16 Mean corpuscular hemoglobin concentration;Glycated hemoglobin levels; CRC cis rs10771431 0.817 rs10843149 chr12:9362067 G/A cg08997352 chr12:9597637 DDX12 -0.46 -6.99 -0.36 1.58e-11 Breast size; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg25460059 chr11:9595544 WEE1 0.45 6.35 0.33 7.26e-10 Response to antipsychotic treatment; CRC cis rs2732480 0.538 rs2468943 chr12:48747249 G/T cg21466736 chr12:48725269 NA 0.51 7.54 0.38 4.54e-13 Hemoglobin concentration;Red blood cell count;Hematocrit; CRC cis rs3008870 0.755 rs2815364 chr1:67498384 C/T cg08660285 chr1:67390436 MIER1;WDR78 0.55 7.59 0.39 3.33e-13 Lymphocyte percentage of white cells; CRC cis rs6691722 0.503 rs6656485 chr1:24707685 A/G cg02336364 chr1:24764700 NIPAL3 0.38 6.25 0.33 1.28e-9 Response to interferon beta in multiple sclerosis; CRC trans rs561341 0.831 rs11658469 chr17:30206426 T/C cg27661571 chr11:113659931 NA 0.62 7.23 0.37 3.45e-12 Hip circumference adjusted for BMI; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg23319046 chr18:3247432 MYL12A 0.42 6.0 0.31 5.12e-9 Anxiety disorder; CRC cis rs6032067 0.929 rs13039213 chr20:43805712 A/C cg10761708 chr20:43804764 PI3 0.51 5.89 0.31 9.53e-9 Blood protein levels; CRC cis rs4474465 0.850 rs7112872 chr11:78227396 C/A cg02023728 chr11:77925099 USP35 -0.35 -5.74 -0.3 2.1e-8 Alzheimer's disease (survival time); CRC cis rs644799 1.000 rs1784135 chr11:95531748 G/A cg03916912 chr11:95522834 CEP57;FAM76B 0.95 18.19 0.71 1.15e-51 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs305851 0.818 rs7761456 chr6:39768005 A/C cg02386599 chr6:39769542 DAAM2 -0.39 -6.17 -0.32 2.06e-9 Lobe attachment (rater-scored or self-reported); CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg21403089 chr7:108166784 PNPLA8 -0.44 -6.99 -0.36 1.54e-11 Myopia (pathological); CRC cis rs10504229 0.683 rs35889486 chr8:58117749 T/A cg21724239 chr8:58056113 NA 0.49 6.81 0.35 4.75e-11 Developmental language disorder (linguistic errors); CRC cis rs35306767 0.715 rs1871622 chr10:1049309 T/G cg26597838 chr10:835615 NA 0.95 11.2 0.53 6.98e-25 Eosinophil percentage of granulocytes; CRC cis rs853679 0.517 rs9368555 chr6:28108967 T/C cg03623178 chr6:28175578 NA 0.98 12.66 0.57 3.31e-30 Depression; CRC cis rs13191362 1.000 rs13220048 chr6:163004325 T/A cg06582575 chr6:163149167 PACRG;PARK2 0.77 10.59 0.5 9.54e-23 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs6502050 0.723 rs11657069 chr17:80083809 C/T cg22110888 chr17:80059540 CCDC57 -0.41 -6.39 -0.33 5.58e-10 Life satisfaction; CRC cis rs5753037 0.585 rs36572 chr22:30200936 T/C cg01021169 chr22:30184971 ASCC2 -0.43 -6.8 -0.35 4.93e-11 Type 1 diabetes; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg04414295 chr14:102606318 WDR20;HSP90AA1 0.43 6.94 0.36 2.07e-11 Liver disease severity in Alagille syndrome; CRC cis rs12477438 0.520 rs6542865 chr2:99764521 C/T cg14399236 chr2:99771627 LIPT1;TSGA10 0.81 14.17 0.62 6.37e-36 Chronic sinus infection; CRC cis rs34779708 0.966 rs12769484 chr10:35465746 G/A cg03585969 chr10:35415529 CREM 0.62 8.37 0.42 1.65e-15 Inflammatory bowel disease;Crohn's disease; CRC trans rs11098499 0.618 rs6858383 chr4:120296772 T/C cg25214090 chr10:38739885 LOC399744 0.62 9.74 0.47 7.35e-20 Corneal astigmatism; CRC cis rs2839186 0.771 rs2280957 chr21:47642272 A/G cg26721908 chr21:47610096 LSS 0.42 6.58 0.34 1.84e-10 Testicular germ cell tumor; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg25845783 chr6:166756218 SFT2D1 0.43 6.11 0.32 2.8e-9 Intelligence (multi-trait analysis); CRC cis rs534126 1.000 rs476826 chr7:142906434 C/T cg04039957 chr7:143013207 CLCN1 -0.35 -6.28 -0.33 1.07e-9 Cancer; CRC cis rs300703 0.515 rs364431 chr2:191399 C/A cg21211680 chr2:198530 NA 0.77 9.75 0.47 6.85e-20 Blood protein levels; CRC cis rs11190604 1.000 rs3793772 chr10:102222825 A/G cg07570687 chr10:102243282 WNT8B 0.45 5.83 0.31 1.3e-8 Palmitoleic acid (16:1n-7) levels; CRC cis rs12586317 0.513 rs17102962 chr14:35478782 A/T cg16230307 chr14:35515116 FAM177A1 0.85 9.86 0.48 2.83e-20 Psoriasis; CRC cis rs1799949 0.894 rs71367985 chr17:41374463 G/A cg07153921 chr17:41440717 NA -0.39 -5.88 -0.31 1e-8 Menopause (age at onset); CRC cis rs10540 1.000 rs61876336 chr11:489537 C/T cg03934478 chr11:495069 RNH1 0.67 7.22 0.37 3.66e-12 Body mass index; CRC cis rs6460942 0.591 rs62451464 chr7:12363059 C/A cg06484146 chr7:12443880 VWDE -0.6 -6.61 -0.34 1.56e-10 Coronary artery disease; CRC cis rs947211 0.950 rs885224 chr1:205753097 A/G cg07167872 chr1:205819463 PM20D1 0.43 5.96 0.31 6.67e-9 Parkinson's disease; CRC trans rs8073060 0.586 rs225288 chr17:33929291 G/A cg19694781 chr19:47549865 TMEM160 -1.04 -14.44 -0.62 6.2e-37 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; CRC trans rs61931739 0.534 rs10844840 chr12:34364517 C/T cg26384229 chr12:38710491 ALG10B 0.67 8.73 0.43 1.3e-16 Morning vs. evening chronotype; CRC cis rs559928 0.606 rs11605856 chr11:63925528 C/T cg19465662 chr11:63993652 NUDT22;TRPT1 0.7 6.7 0.35 8.83e-11 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; CRC cis rs3733585 0.699 rs10017674 chr4:9967053 T/C cg00071950 chr4:10020882 SLC2A9 -0.55 -9.72 -0.47 8.53e-20 Cleft plate (environmental tobacco smoke interaction); CRC cis rs8060686 0.516 rs7193701 chr16:68185160 A/G cg26727032 chr16:67993705 SLC12A4 0.52 7.65 0.39 2.2e-13 HDL cholesterol;Metabolic syndrome; CRC cis rs992157 0.767 rs2382822 chr2:219173327 T/C cg13835894 chr2:219148914 PNKD;TMBIM1 -0.34 -6.32 -0.33 8.74e-10 Colorectal cancer; CRC cis rs7615952 0.534 rs1503072 chr3:125754691 C/T cg04553112 chr3:125709451 NA -0.51 -5.71 -0.3 2.5e-8 Blood pressure (smoking interaction); CRC cis rs2019137 0.868 rs3748916 chr2:113984033 C/T cg19083407 chr2:113993142 PAX8;LOC440839;LOC654433 -0.47 -6.66 -0.34 1.15e-10 Lymphocyte counts; CRC cis rs6701037 0.625 rs72719370 chr1:175128536 G/C cg17845761 chr1:175162550 KIAA0040 -0.27 -5.61 -0.3 4.39e-8 Alcohol dependence; CRC cis rs2857891 0.650 rs2638087 chr11:6990516 C/T cg22096450 chr11:6947773 ZNF215 0.51 5.97 0.31 6.31e-9 Response to cytadine analogues (cytosine arabinoside); CRC cis rs9372498 0.536 rs62421536 chr6:118727972 G/A cg24463073 chr6:118973353 C6orf204 0.51 6.43 0.33 4.61e-10 Diastolic blood pressure; CRC cis rs7212938 0.509 rs3893044 chr17:38103016 C/T cg17344932 chr17:38183730 MED24;SNORD124 0.46 7.26 0.37 2.73e-12 Asthma and hay fever; CRC cis rs877282 1.000 rs11253370 chr10:773712 G/A cg17470449 chr10:769945 NA 0.62 9.04 0.45 1.33e-17 Uric acid levels; CRC cis rs6694672 1.000 rs1759008 chr1:197026895 G/T cg13682187 chr1:196946512 CFHR5 -0.47 -7.79 -0.39 8.69e-14 Asthma; CRC cis rs9326248 0.861 rs4938353 chr11:117046197 G/A cg26566898 chr11:117069891 TAGLN 0.39 7.28 0.37 2.47e-12 Blood protein levels; CRC cis rs870825 0.616 rs7683615 chr4:185618373 C/T cg04058563 chr4:185651563 MLF1IP 0.72 9.38 0.46 1.12e-18 Blood protein levels; CRC cis rs2997447 0.655 rs55820521 chr1:26374286 C/T cg19633962 chr1:26362018 EXTL1 -0.61 -6.3 -0.33 9.3e-10 QRS complex (12-leadsum); CRC cis rs2404602 0.530 rs12915184 chr15:76965922 G/A cg23625390 chr15:77176239 SCAPER -0.77 -10.43 -0.5 3.52e-22 Blood metabolite levels; CRC cis rs651907 0.535 rs34648996 chr3:101511202 A/G cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.59 7.8 0.4 8.2e-14 Colorectal cancer; CRC cis rs12497850 0.931 rs10780033 chr3:48891275 T/C cg20833759 chr3:49053208 WDR6;DALRD3 0.53 9.22 0.45 3.73e-18 Parkinson's disease; CRC cis rs4919694 1.000 rs58700372 chr10:104800205 T/C cg04362960 chr10:104952993 NT5C2 1.13 10.63 0.51 6.83e-23 Arsenic metabolism; CRC trans rs11039798 0.844 rs6485820 chr11:48264711 A/G cg15704280 chr7:45808275 SEPT13 0.67 6.4 0.33 5.39e-10 Axial length; CRC cis rs6570726 0.791 rs12208812 chr6:145900924 T/G cg05347473 chr6:146136440 FBXO30 0.4 6.11 0.32 2.83e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs6964587 1.000 rs7800582 chr7:91701346 G/A cg17063962 chr7:91808500 NA 0.8 14.04 0.61 1.97e-35 Breast cancer; CRC trans rs7819412 0.775 rs4841489 chr8:10936811 A/G cg06636001 chr8:8085503 FLJ10661 -0.61 -9.23 -0.45 3.41e-18 Triglycerides; CRC trans rs6561151 0.681 rs17065161 chr13:44443723 A/T cg12856521 chr11:46389249 DGKZ 0.73 10.47 0.5 2.51e-22 Crohn's disease; CRC cis rs652260 1.000 rs590394 chr19:7902505 C/T cg26014689 chr19:7917955 EVI5L -0.53 -8.68 -0.43 1.88e-16 Menarche (age at onset); CRC cis rs311392 1.000 rs2671804 chr8:55088853 C/T cg06042504 chr8:55087323 NA -0.43 -6.64 -0.34 1.3100000000000001e-10 Pelvic organ prolapse (moderate/severe); CRC cis rs7216064 1.000 rs11870068 chr17:65944515 A/C cg12091567 chr17:66097778 LOC651250 -0.62 -7.26 -0.37 2.75e-12 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg20769334 chr22:50913335 SBF1 -0.42 -6.38 -0.33 5.88e-10 Myopia (pathological); CRC cis rs1008375 0.966 rs4698642 chr4:17679174 A/T cg04450456 chr4:17643702 FAM184B 0.39 6.25 0.33 1.29e-9 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs3736485 0.966 rs11636170 chr15:51767087 G/T cg08986416 chr15:51914746 DMXL2 -0.4 -5.79 -0.3 1.68e-8 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs7811142 0.943 rs3900792 chr7:100004577 C/G cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.73 10.22 0.49 1.75e-21 Platelet count; CRC cis rs4319547 0.656 rs6488951 chr12:122873928 A/G cg23029597 chr12:123009494 RSRC2 -0.55 -6.7 -0.35 9.14e-11 Body mass index; CRC cis rs1552244 0.882 rs3846168 chr3:9996925 C/T cg13047869 chr3:10149882 C3orf24 0.49 6.77 0.35 5.8200000000000003e-11 Alzheimer's disease; CRC cis rs4319547 0.695 rs10734915 chr12:122873408 A/C cg05707623 chr12:122985044 ZCCHC8 -0.64 -7.88 -0.4 4.7e-14 Body mass index; CRC cis rs4268898 0.571 rs1986478 chr2:24468545 G/A cg06627628 chr2:24431161 ITSN2 -0.86 -11.76 -0.54 6.57e-27 Asthma; CRC trans rs61931739 0.500 rs11053273 chr12:34547255 C/T cg26384229 chr12:38710491 ALG10B 0.68 8.8 0.44 7.69e-17 Morning vs. evening chronotype; CRC cis rs3806843 0.966 rs11741994 chr5:140145949 G/A cg19875535 chr5:140030758 IK 0.61 10.01 0.48 9.04e-21 Depressive symptoms (multi-trait analysis); CRC cis rs9297145 0.916 rs4236540 chr7:98769025 A/C cg05967295 chr7:98741636 SMURF1 0.97 17.14 0.69 1.62e-47 Crohn's disease;Inflammatory bowel disease;Ulcerative colitis; CRC cis rs9902453 0.935 rs9898424 chr17:28392946 G/A cg26525008 chr17:28256777 EFCAB5;SSH2 -0.59 -8.74 -0.43 1.22e-16 Coffee consumption (cups per day); CRC cis rs9309711 0.772 rs9309714 chr2:3491830 G/C cg10845886 chr2:3471009 TTC15 -0.7 -11.03 -0.52 2.75e-24 Neurofibrillary tangles; CRC trans rs8035957 1.000 rs4924273 chr15:38846738 C/G cg04314247 chr1:95286125 SLC44A3 -0.46 -6.11 -0.32 2.83e-9 Type 1 diabetes; CRC cis rs9486719 0.741 rs2049927 chr6:96848958 C/G cg06623918 chr6:96969491 KIAA0776 -0.72 -8.06 -0.41 1.41e-14 Migraine;Coronary artery disease; CRC cis rs933688 1.000 rs7715402 chr5:90679504 T/A cg26981201 chr5:90679533 LOC100129716;ARRDC3 1.03 18.07 0.71 3.47e-51 Smoking behavior; CRC cis rs1552244 1.000 rs2272125 chr3:10138069 A/C cg13047869 chr3:10149882 C3orf24 0.51 7.3 0.37 2.21e-12 Alzheimer's disease; CRC cis rs611744 0.625 rs4735055 chr8:109286642 G/A cg21045802 chr8:109455806 TTC35 0.42 6.49 0.34 3.15e-10 Dupuytren's disease; CRC cis rs7940866 0.845 rs2324314 chr11:130834589 A/C cg12179176 chr11:130786555 SNX19 0.57 8.36 0.42 1.81e-15 Schizophrenia; CRC cis rs6952808 0.756 rs4719311 chr7:1881813 C/T cg21782813 chr7:2030301 MAD1L1 0.4 7.04 0.36 1.15e-11 Bipolar disorder and schizophrenia; CRC cis rs7215564 0.908 rs34950888 chr17:78661779 T/G cg09596252 chr17:78655493 RPTOR 0.57 6.12 0.32 2.59e-9 Myopia (pathological); CRC cis rs4253772 0.591 rs6008361 chr22:46652372 A/G cg03482458 chr22:46692211 CN5H6.4;GTSE1 -0.5 -6.73 -0.35 7.69e-11 LDL cholesterol;Cholesterol, total; CRC cis rs4803480 1.000 rs4803480 chr19:42066279 A/G cg08478046 chr19:42093086 CEACAM21 -0.33 -5.87 -0.31 1.06e-8 Schizophrenia; CRC cis rs763121 0.853 rs9607566 chr22:39075434 C/G cg06544989 chr22:39130855 UNC84B 0.45 6.95 0.36 1.96e-11 Menopause (age at onset); CRC cis rs60843830 1.000 rs10193373 chr2:281886 T/G cg00108164 chr2:264199 ACP1;SH3YL1 0.6 9.46 0.46 6.12e-19 Spherical equivalent (joint analysis main effects and education interaction); CRC cis rs1799949 1.000 rs1824889 chr17:41421876 C/G cg25072359 chr17:41440525 NA 0.46 6.91 0.36 2.59e-11 Menopause (age at onset); CRC cis rs2075371 0.933 rs2544181 chr7:133944934 C/T cg02659138 chr7:134003124 SLC35B4 0.38 6.51 0.34 2.78e-10 Mean platelet volume; CRC cis rs9311474 0.629 rs11709284 chr3:52559705 G/A cg08222913 chr3:52553049 STAB1 -0.42 -8.47 -0.42 8.56e-16 Electroencephalogram traits; CRC cis rs6121246 0.909 rs6060793 chr20:30288830 T/G cg13852791 chr20:30311386 BCL2L1 0.69 11.09 0.52 1.68e-24 Mean corpuscular hemoglobin; CRC cis rs7949030 0.591 rs35156678 chr11:62369881 G/A cg22862634 chr11:62369728 EML3;MTA2 0.57 9.96 0.48 1.32e-20 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; CRC cis rs4665809 1.000 rs4233710 chr2:26291565 G/A cg04944784 chr2:26401820 FAM59B -0.64 -7.95 -0.4 3.06e-14 Gut microbiome composition (summer); CRC cis rs11098499 0.913 rs11098496 chr4:120167466 C/G cg24375607 chr4:120327624 NA 0.44 6.91 0.36 2.56e-11 Corneal astigmatism; CRC trans rs2303319 0.504 rs55821334 chr2:162452014 A/G cg22988483 chr14:93581567 ITPK1 -0.66 -6.07 -0.32 3.43e-9 Cognitive function; CRC cis rs250677 0.652 rs36042 chr5:148439782 G/T cg18129178 chr5:148520854 ABLIM3 -0.4 -5.9 -0.31 8.84e-9 Breast cancer; CRC cis rs6988636 1.000 rs9987357 chr8:124187620 T/G cg27053337 chr8:124217698 FAM83A 0.45 6.82 0.35 4.48e-11 Urinary uromodulin levels; CRC cis rs736801 0.780 rs12521868 chr5:131784393 A/C cg21138405 chr5:131827807 IRF1 0.36 6.34 0.33 7.5e-10 Breast cancer;Mosquito bite size; CRC cis rs427943 0.750 rs1556317 chr21:46605694 C/T cg19498844 chr21:46707878 POFUT2;LOC642852 0.45 5.92 0.31 7.91e-9 Body mass index; CRC cis rs12908161 1.000 rs34900908 chr15:85257599 G/A cg11189052 chr15:85197271 WDR73 0.61 8.88 0.44 4.41e-17 Schizophrenia; CRC cis rs910316 1.000 rs11159117 chr14:75584867 C/T cg11812906 chr14:75593930 NEK9 0.62 10.11 0.49 4.2e-21 Height; CRC cis rs8072100 0.935 rs12150231 chr17:45717091 G/A cg25173405 chr17:45401733 C17orf57 0.46 7.1 0.36 7.96e-12 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs727505 0.954 rs66526112 chr7:124504074 C/A cg23710748 chr7:124431027 NA -0.8 -14.18 -0.62 6.24e-36 Lewy body disease; CRC cis rs736801 0.740 rs12515180 chr5:131785684 C/T cg14196790 chr5:131705035 SLC22A5 0.36 5.8 0.3 1.56e-8 Breast cancer;Mosquito bite size; CRC trans rs4346635 0.528 rs1495489 chr4:81416501 T/C cg13904968 chr20:56136012 PCK1 -0.19 -6.02 -0.31 4.64e-9 Colonoscopy-negative controls vs population controls; CRC cis rs28830936 1.000 rs9672298 chr15:41912368 A/C cg17847044 chr15:42102381 MAPKBP1 -0.29 -6.12 -0.32 2.6e-9 Diastolic blood pressure; CRC cis rs34779708 0.966 rs11010102 chr10:35411066 T/A cg03585969 chr10:35415529 CREM 0.59 7.89 0.4 4.67e-14 Inflammatory bowel disease;Crohn's disease; CRC cis rs7487075 0.930 rs11183468 chr12:46806261 A/T cg17501823 chr12:47219793 SLC38A4 0.32 5.97 0.31 6.14e-9 Itch intensity from mosquito bite; CRC cis rs868943 0.714 rs66475830 chr6:116408802 T/C cg15226275 chr6:116381976 FRK 0.3 7.14 0.37 6.1e-12 Total cholesterol levels; CRC cis rs4664293 0.585 rs35081473 chr2:160536481 G/C cg08347373 chr2:160653686 CD302 0.36 5.92 0.31 8.09e-9 Monocyte percentage of white cells; CRC cis rs9488822 0.596 rs13192549 chr6:116338352 C/A cg15226275 chr6:116381976 FRK 0.27 7.3 0.37 2.24e-12 Cholesterol, total;LDL cholesterol; CRC cis rs2836754 1.000 rs11701004 chr21:40292102 C/G cg20434300 chr21:40194735 ETS2 -0.34 -5.8 -0.3 1.52e-8 Crohn's disease;Body mass index; CRC cis rs1005277 0.505 rs200910 chr10:38108176 C/T cg25427524 chr10:38739819 LOC399744 -0.73 -12.79 -0.58 1.07e-30 Extrinsic epigenetic age acceleration; CRC cis rs10191773 0.522 rs6747639 chr2:112967458 C/T cg23609528 chr2:113191194 RGPD5;RGPD8 0.63 5.61 0.3 4.26e-8 Yeast infection; CRC cis rs7945705 0.902 rs2012696 chr11:8995818 A/C cg21881798 chr11:8931708 C11orf17;ST5 0.65 9.98 0.48 1.17e-20 Hemoglobin concentration; CRC cis rs7312933 0.510 rs10880223 chr12:42413443 G/A cg17420585 chr12:42539391 GXYLT1 -0.62 -10.64 -0.51 6.19e-23 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CRC cis rs34779708 0.897 rs4934527 chr10:35281118 T/A cg03585969 chr10:35415529 CREM 0.59 8.06 0.41 1.41e-14 Inflammatory bowel disease;Crohn's disease; CRC cis rs12134245 0.874 rs35115044 chr1:92021650 A/G cg07090678 chr1:91966139 CDC7 0.37 5.85 0.31 1.19e-8 Breast cancer; CRC cis rs11227306 0.934 rs7102454 chr11:65594820 C/T cg26695010 chr11:65641043 EFEMP2 0.45 6.32 0.33 8.49e-10 DNA methylation (variation); CRC cis rs3790645 1.000 rs897641 chr1:26881806 C/A cg23229016 chr1:26872525 RPS6KA1 0.3 7.32 0.37 1.89e-12 Glucose homeostasis traits; CRC cis rs12142240 0.698 rs1135459 chr1:46815930 C/T cg14993813 chr1:46806288 NSUN4 -0.5 -6.4 -0.33 5.38e-10 Menopause (age at onset); CRC cis rs3820068 0.603 rs72645887 chr1:15929905 G/C cg13390004 chr1:15929781 NA 0.51 7.2 0.37 4.22e-12 Systolic blood pressure; CRC cis rs12586317 0.547 rs4982234 chr14:35460106 T/A cg16230307 chr14:35515116 FAM177A1 0.85 10.08 0.49 5.15e-21 Psoriasis; CRC cis rs10089 0.953 rs6595807 chr5:127531603 G/T cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.7 9.55 0.47 3.03e-19 Ileal carcinoids; CRC cis rs2336384 1.000 rs2878677 chr1:12053264 C/T cg13216073 chr1:12042593 MFN2 -0.47 -7.18 -0.37 4.74e-12 Platelet count; CRC cis rs863345 0.604 rs1578763 chr1:158497414 C/T cg12129480 chr1:158549410 OR10X1 -0.29 -5.95 -0.31 6.94e-9 Pneumococcal bacteremia; CRC cis rs8031584 0.918 rs61997139 chr15:31273602 C/G cg14829155 chr15:31115871 NA -0.49 -8.15 -0.41 7.73e-15 Huntington's disease progression; CRC cis rs7824557 0.591 rs2736283 chr8:11225910 A/G cg08265495 chr8:11212668 TDH -0.32 -5.72 -0.3 2.44e-8 Retinal vascular caliber; CRC cis rs9611565 0.625 rs9607819 chr22:41958862 C/G cg17554472 chr22:41940697 POLR3H -0.53 -5.65 -0.3 3.42e-8 Vitiligo; CRC cis rs11628318 0.614 rs1190337 chr14:103106159 A/C cg23071808 chr14:103021642 NA -0.65 -7.24 -0.37 3.26e-12 Platelet count; CRC trans rs1728785 1.000 rs698719 chr16:68560125 C/T cg04657470 chr2:198365150 HSPE1;HSPD1 0.54 6.43 0.33 4.46e-10 Ulcerative colitis; CRC cis rs7246657 0.943 rs10417503 chr19:37842735 T/C cg23950597 chr19:37808831 NA -0.54 -6.5 -0.34 2.93e-10 Coronary artery calcification; CRC cis rs6867032 0.958 rs4246754 chr5:2014776 A/C cg26168224 chr5:2018326 NA 0.91 15.45 0.65 6.88e-41 Gut microbiome composition (winter); CRC cis rs11155671 0.530 rs9371223 chr6:150214806 T/C cg07701084 chr6:150067640 NUP43 0.54 7.65 0.39 2.24e-13 Testicular germ cell tumor; CRC cis rs875971 0.571 rs160647 chr7:65554352 C/T cg18876405 chr7:65276391 NA -0.44 -5.97 -0.31 6.25e-9 Aortic root size; CRC cis rs1580019 0.587 rs7804457 chr7:32557981 A/G cg14728415 chr7:32535168 LSM5;AVL9 0.45 6.38 0.33 6.1e-10 Cognitive ability; CRC cis rs1577917 0.958 rs1337843 chr6:86675545 A/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.51 -6.86 -0.35 3.36e-11 Response to antipsychotic treatment; CRC cis rs9549367 0.774 rs2287246 chr13:113889127 A/G cg00898013 chr13:113819073 PROZ -0.45 -6.77 -0.35 5.98e-11 Platelet distribution width; CRC cis rs2204008 0.777 rs2387813 chr12:38382091 A/C cg13010199 chr12:38710504 ALG10B 0.47 6.43 0.33 4.6e-10 Bladder cancer; CRC cis rs7264396 0.635 rs6058346 chr20:34481043 G/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.56 -9.21 -0.45 3.87e-18 Total cholesterol levels; CRC cis rs12291225 0.877 rs11023160 chr11:14264225 T/A cg19336497 chr11:14380999 RRAS2 -0.41 -6.46 -0.34 3.72e-10 Sense of smell; CRC cis rs2415984 0.579 rs12147941 chr14:46972907 A/G cg14871534 chr14:47121158 RPL10L -0.42 -6.22 -0.32 1.49e-9 Number of children ever born; CRC cis rs4423214 1.000 rs732934 chr11:71186476 G/A cg05163923 chr11:71159392 DHCR7 0.67 9.54 0.47 3.34e-19 Vitamin D levels; CRC cis rs9287719 0.967 rs12622765 chr2:10728331 T/C cg00105475 chr2:10696890 NA 0.45 7.26 0.37 2.75e-12 Prostate cancer; CRC trans rs2303319 0.504 rs62189041 chr2:162599506 T/C cg23919916 chr10:103825097 HPS6 -0.69 -6.01 -0.31 4.8e-9 Cognitive function; CRC cis rs28386778 0.897 rs1043127 chr17:61791210 T/G cg25654072 chr17:61904446 PSMC5;FTSJ3 0.72 11.07 0.52 2.05e-24 Prudent dietary pattern; CRC trans rs12744310 0.887 rs35410722 chr1:41796264 C/T cg19175123 chr10:103411746 FBXW4 0.44 6.0 0.31 5.21e-9 Cognitive ability (multi-trait analysis);Intelligence;Cognitive ability; CRC cis rs1552172 0.853 rs2018027 chr1:145595820 A/G cg25221984 chr1:145714143 CD160 0.36 5.69 0.3 2.8e-8 Breast cancer; CRC cis rs875971 0.862 rs4718330 chr7:65715243 G/A cg18252515 chr7:66147081 NA 0.4 5.75 0.3 2.04e-8 Aortic root size; CRC cis rs6088590 1.000 rs3787222 chr20:33333040 T/A cg08999081 chr20:33150536 PIGU 0.51 8.6 0.43 3.42e-16 Coronary artery disease; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg12402495 chr1:154192844 C1orf43;UBAP2L 0.44 6.25 0.33 1.28e-9 Response to antipsychotic treatment; CRC cis rs8067545 0.611 rs77449863 chr17:20191860 C/G cg13482628 chr17:19912719 NA -0.49 -7.79 -0.39 8.69e-14 Schizophrenia; CRC cis rs908922 0.676 rs10888491 chr1:152492622 A/G cg23254163 chr1:152506842 NA 0.5 10.14 0.49 3.42e-21 Hair morphology; CRC cis rs514406 0.861 rs7417821 chr1:53295117 A/G cg27535305 chr1:53392650 SCP2 -0.38 -7.19 -0.37 4.34e-12 Monocyte count; CRC cis rs10256972 0.732 rs12701856 chr7:1107707 C/T cg04025307 chr7:1156635 C7orf50 0.56 8.48 0.42 7.76e-16 Longevity;Endometriosis; CRC cis rs3087591 0.960 rs2952984 chr17:29469614 T/C cg24425628 chr17:29625626 OMG;NF1 0.85 15.82 0.66 2.64e-42 Hip circumference; CRC trans rs1814175 0.754 rs28663627 chr11:50048829 C/T cg11707556 chr5:10655725 ANKRD33B -0.44 -8.65 -0.43 2.33e-16 Height; CRC cis rs17331151 0.505 rs35371456 chr3:52563462 C/T cg07884673 chr3:53033167 SFMBT1 0.76 6.08 0.32 3.31e-9 Immune reponse to smallpox (secreted IL-2); CRC cis rs832540 0.656 rs832573 chr5:56159578 T/C cg18230493 chr5:56204884 C5orf35 -0.4 -5.67 -0.3 3.18e-8 Coronary artery disease; CRC cis rs7829975 0.714 rs60315134 chr8:8670599 A/G cg06636001 chr8:8085503 FLJ10661 0.66 10.3 0.49 9.71e-22 Mood instability; CRC cis rs1059312 0.771 rs7974764 chr12:129296588 G/C cg09035930 chr12:129282057 SLC15A4 0.53 8.87 0.44 4.85e-17 Systemic lupus erythematosus; CRC cis rs3015497 0.554 rs8011039 chr14:51091267 C/T cg09863266 chr14:51125203 SAV1 -0.31 -5.92 -0.31 8.27e-9 Mean platelet volume; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg14760355 chr2:176046503 ATP5G3 0.49 6.88 0.35 2.98e-11 Response to antipsychotic treatment; CRC cis rs6912958 0.712 rs4706294 chr6:88317675 G/C cg08069147 chr6:88032118 GJB7;C6orf162 -0.58 -8.77 -0.44 9.85e-17 Monocyte percentage of white cells; CRC cis rs240764 0.658 rs9485410 chr6:101261007 A/G cg09795085 chr6:101329169 ASCC3 0.41 5.69 0.3 2.79e-8 Neuroticism; CRC cis rs10905065 0.804 rs2175630 chr10:5834736 A/C cg11519256 chr10:5708881 ASB13 -0.47 -6.66 -0.34 1.18e-10 Menopause (age at onset); CRC cis rs28386778 0.897 rs7210443 chr17:61785374 A/G cg11494091 chr17:61959527 GH2 0.62 10.52 0.5 1.7e-22 Prudent dietary pattern; CRC cis rs523522 0.962 rs11065154 chr12:120971417 T/C cg27279351 chr12:120934652 DYNLL1 0.77 11.31 0.53 2.81e-25 High light scatter reticulocyte count; CRC cis rs7959452 0.590 rs11177643 chr12:69785712 T/G cg14784868 chr12:69753453 YEATS4 0.84 14.69 0.63 6.53e-38 Blood protein levels; CRC trans rs9858542 0.953 rs7622302 chr3:49547561 T/C cg21665057 chr3:196295764 WDR53;FBXO45 -0.65 -8.86 -0.44 5.12e-17 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs17401966 0.931 rs11584023 chr1:10302596 A/G cg19773385 chr1:10388646 KIF1B -0.68 -10.92 -0.52 6.84e-24 Hepatocellular carcinoma; CRC cis rs9359856 0.673 rs2039053 chr6:90303760 G/A cg13799429 chr6:90582589 CASP8AP2 0.6 7.85 0.4 5.96e-14 Bipolar disorder; CRC cis rs6860806 0.661 rs4705927 chr5:131578608 C/G cg02033258 chr5:131593261 PDLIM4 0.4 7.85 0.4 5.89e-14 Breast cancer; CRC cis rs7647973 0.580 rs11130184 chr3:49229930 C/T cg03060546 chr3:49711283 APEH 0.47 7.04 0.36 1.1e-11 Menarche (age at onset); CRC cis rs11168351 0.926 rs10875719 chr12:48411158 T/C cg15465823 chr12:48382534 COL2A1 0.35 5.83 0.31 1.33e-8 Bipolar disorder and schizophrenia; CRC cis rs10504229 1.000 rs66796009 chr8:58174529 G/A cg02725872 chr8:58115012 NA -0.38 -6.4 -0.33 5.3e-10 Developmental language disorder (linguistic errors); CRC trans rs3749237 1.000 rs11130216 chr3:49736172 C/A cg21659725 chr3:3221576 CRBN 0.57 8.02 0.4 1.87e-14 Resting heart rate; CRC cis rs17102884 0.506 rs887746 chr14:75403817 C/T cg08847533 chr14:75593920 NEK9 -0.43 -6.16 -0.32 2.13e-9 Neuroticism; CRC cis rs9457247 1.000 rs397713 chr6:167386714 G/A cg23791538 chr6:167370224 RNASET2 -0.38 -5.97 -0.31 6.08e-9 Crohn's disease; CRC cis rs10193935 0.901 rs222464 chr2:42643889 C/T cg27598129 chr2:42591480 NA -0.66 -7.47 -0.38 7.09e-13 Colonoscopy-negative controls vs population controls; CRC cis rs995000 0.868 rs1168107 chr1:63161173 A/T cg19896129 chr1:63156450 NA -0.45 -6.87 -0.35 3.3e-11 Triglyceride levels; CRC cis rs2745959 0.548 rs2745949 chr1:208058183 T/C cg09788693 chr1:208063733 CD34 0.48 6.34 0.33 7.74e-10 Resting heart rate; CRC cis rs477692 0.625 rs4751104 chr10:131405358 G/A cg05714579 chr10:131428358 MGMT -0.78 -12.05 -0.55 6.1e-28 Response to temozolomide; CRC cis rs929354 0.742 rs11980541 chr7:156988776 G/C cg16102536 chr7:156981717 UBE3C 0.4 6.76 0.35 6.39e-11 Body mass index; CRC cis rs2050392 0.517 rs2771242 chr10:30762973 C/T cg25182066 chr10:30743637 MAP3K8 -0.5 -6.79 -0.35 5.24e-11 Inflammatory bowel disease; CRC cis rs838147 0.537 rs632111 chr19:49208978 A/G cg21064579 chr19:49206444 FUT2 0.49 8.68 0.43 1.85e-16 Dietary macronutrient intake; CRC cis rs875971 0.545 rs4441996 chr7:65588220 T/C cg03233332 chr7:66118400 NA 0.45 6.25 0.33 1.24e-9 Aortic root size; CRC cis rs1760803 0.754 rs12028554 chr1:154223101 G/A cg26808167 chr1:154192205 UBAP2L;C1orf43 -0.37 -6.37 -0.33 6.46e-10 Nicotine dependence; CRC trans rs11105468 0.922 rs7960337 chr12:90277578 T/C cg23572944 chr11:60720130 SLC15A3 -0.43 -5.98 -0.31 5.8e-9 Febrile seizures;Febrile seizures (MMR vaccine-related);Febrile seizures (MMR vaccine-unrelated); CRC cis rs7216064 0.953 rs4790905 chr17:65863350 C/A cg12091567 chr17:66097778 LOC651250 -0.63 -7.9 -0.4 4.2e-14 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CRC cis rs9372498 0.536 rs9489395 chr6:118758884 T/C cg01339444 chr6:118972232 C6orf204 0.52 5.9 0.31 8.98e-9 Diastolic blood pressure; CRC cis rs56235845 0.964 rs4075958 chr5:176784512 A/G cg16006841 chr5:176797999 RGS14 -0.76 -11.47 -0.53 7.73e-26 Hemoglobin concentration;Hematocrit; CRC cis rs8072100 0.701 rs2013383 chr17:45791123 T/G cg19784903 chr17:45786737 TBKBP1 -0.35 -5.82 -0.31 1.39e-8 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs62408225 1.000 rs62408235 chr6:90978383 T/C cg06866423 chr6:90926672 BACH2 0.51 8.44 0.42 1.01e-15 Eosinophil counts;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC cis rs823143 0.570 rs823084 chr1:205798313 G/T cg11965913 chr1:205819406 PM20D1 0.66 10.72 0.51 3.5e-23 Monocyte percentage of white cells; CRC cis rs1018836 0.632 rs1028255 chr8:91485578 A/T cg16814680 chr8:91681699 NA -0.64 -9.77 -0.47 5.98e-20 Ejection fraction in Tripanosoma cruzi seropositivity; CRC cis rs1577917 1.000 rs9647603 chr6:86639341 T/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.51 -6.86 -0.35 3.34e-11 Response to antipsychotic treatment; CRC trans rs2303319 0.504 rs56026147 chr2:162614089 T/C cg12500891 chr11:57225987 NA -0.65 -6.06 -0.32 3.77e-9 Cognitive function; CRC cis rs2836974 0.568 rs2836969 chr21:40648265 G/A cg22974920 chr21:40686053 BRWD1 -0.43 -5.94 -0.31 7.38e-9 Cognitive function; CRC cis rs12711979 0.509 rs12711972 chr2:3823786 T/C cg17052675 chr2:3827356 NA -0.86 -21.11 -0.76 3.77e-63 Itch intensity from mosquito bite adjusted by bite size; CRC cis rs13031619 0.660 rs35668314 chr2:3702673 C/T cg19052272 chr2:3704530 ALLC -0.88 -10.67 -0.51 5.23e-23 Response to inhaled corticosteroid treatment in asthma (change in FEV1); CRC cis rs7811142 0.943 rs111757992 chr7:100016354 A/C cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.63 8.41 0.42 1.3e-15 Platelet count; CRC cis rs8180040 0.764 rs11130115 chr3:47181661 C/A cg02527881 chr3:46936655 PTH1R -0.4 -7.44 -0.38 8.8e-13 Colorectal cancer; CRC cis rs9547692 1.000 rs11619849 chr13:37468238 A/G cg01493522 chr13:37497338 NA -0.52 -7.16 -0.37 5.21e-12 Coronary artery disease; CRC cis rs2836974 0.533 rs418298 chr21:40536654 A/T cg17971929 chr21:40555470 PSMG1 0.75 12.03 0.55 6.97e-28 Cognitive function; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg01537289 chr6:34359621 NUDT3 0.42 5.99 0.31 5.49e-9 Intelligence (multi-trait analysis); CRC cis rs2108622 0.649 rs113055956 chr19:15977312 T/A cg13772218 chr19:15982569 NA 0.45 6.32 0.33 8.39e-10 Circulating phylloquinone levels;Vitamin E levels;Acenocoumarol maintenance dosage;Response to Vitamin E supplementation;Metabolite levels;Warfarin maintenance dose; CRC cis rs7618915 0.571 rs6778844 chr3:52596398 C/T cg18099408 chr3:52552593 STAB1 0.47 7.64 0.39 2.39e-13 Bipolar disorder; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg27119428 chr11:133734513 NA -0.35 -6.22 -0.32 1.48e-9 Liver disease severity in Alagille syndrome; CRC cis rs4423214 0.879 rs1630498 chr11:71150785 A/C cg05163923 chr11:71159392 DHCR7 -0.63 -7.82 -0.4 7.25e-14 Vitamin D levels; CRC cis rs910316 1.000 rs4903284 chr14:75592483 G/C cg11812906 chr14:75593930 NEK9 0.61 9.51 0.46 4.06e-19 Height; CRC cis rs7552404 0.924 rs7544117 chr1:76158246 A/G cg03433033 chr1:76189801 ACADM 0.92 14.18 0.62 5.85e-36 Blood metabolite levels;Acylcarnitine levels; CRC cis rs1200821 0.529 rs2505707 chr10:37801254 T/C cg00409905 chr10:38381863 ZNF37A -0.47 -7.4 -0.38 1.16e-12 Hemostatic factors and hematological phenotypes; CRC cis rs35110281 0.805 rs8131005 chr21:45041954 T/C cg01579765 chr21:45077557 HSF2BP -0.31 -5.75 -0.3 2.01e-8 Mean corpuscular volume; CRC cis rs4819052 0.851 rs28622522 chr21:46676599 G/T cg02159808 chr21:46707872 POFUT2;LOC642852 0.53 6.96 0.36 1.89e-11 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs6502050 0.731 rs76421195 chr17:80109326 T/C cg13198984 chr17:80129470 CCDC57 0.46 8.16 0.41 6.94e-15 Life satisfaction; CRC cis rs10979 1.000 rs9403506 chr6:143887805 C/G cg25407410 chr6:143891975 LOC285740 -0.83 -13.54 -0.6 1.61e-33 Hypospadias; CRC trans rs56176327 0.532 rs9849038 chr3:49771990 A/G cg21659725 chr3:3221576 CRBN -0.66 -7.53 -0.38 4.98e-13 Intelligence (multi-trait analysis); CRC cis rs728616 0.681 rs34816332 chr10:81907967 G/A cg11900509 chr10:81946545 ANXA11 -0.73 -8.4 -0.42 1.32e-15 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs6815814 0.950 rs9306967 chr4:38807911 G/C cg06935464 chr4:38784597 TLR10 0.58 7.07 0.36 9.44e-12 Breast cancer; CRC trans rs12599106 0.629 rs1391904 chr16:34548934 C/T cg26668828 chr6:292823 DUSP22 -0.59 -8.68 -0.43 1.82e-16 Menopause (age at onset); CRC cis rs9322193 0.962 rs9322220 chr6:150104033 G/C cg05861140 chr6:150128134 PCMT1 -0.43 -7.05 -0.36 1.03e-11 Lung cancer; CRC cis rs6577655 0.517 rs6998749 chr8:135584316 A/G cg17885191 chr8:135476712 NA -0.5 -5.65 -0.3 3.47e-8 Visceral adipose tissue/subcutaneous adipose tissue ratio; CRC cis rs7613875 0.620 rs17657664 chr3:50032008 T/G cg24110177 chr3:50126178 RBM5 -0.53 -8.04 -0.41 1.61e-14 Body mass index; CRC cis rs597539 0.652 rs514833 chr11:68657734 C/T cg04772025 chr11:68637568 NA 0.48 7.36 0.38 1.51e-12 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs4888262 0.545 rs12716768 chr16:74556486 A/G cg01733217 chr16:74700730 RFWD3 -0.76 -11.37 -0.53 1.68e-25 Testicular germ cell tumor; CRC cis rs11971779 0.711 rs6961204 chr7:139047399 T/G cg07862535 chr7:139043722 LUC7L2 0.96 11.66 0.54 1.59e-26 Diisocyanate-induced asthma; CRC cis rs2944591 0.505 rs2004202 chr2:233790289 C/G cg11972305 chr2:233791962 NGEF -0.44 -6.79 -0.35 5.31e-11 Autism spectrum disorder or schizophrenia; CRC trans rs57221529 0.825 rs72703051 chr5:582997 G/A cg25482853 chr8:67687455 SGK3 1.27 14.14 0.61 8.27e-36 Lung disease severity in cystic fibrosis; CRC trans rs916888 0.773 rs199447 chr17:44812188 C/T cg22433210 chr17:43662623 NA 0.97 10.25 0.49 1.36e-21 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs3126085 0.515 rs11204994 chr1:152358640 G/T cg09127314 chr1:152161683 NA -0.44 -5.85 -0.31 1.2e-8 Atopic dermatitis; CRC cis rs172166 0.516 rs2021826 chr6:28132756 G/A cg12273811 chr6:28175739 NA 0.46 6.93 0.36 2.18e-11 Cardiac Troponin-T levels; CRC cis rs4481887 0.962 rs10788770 chr1:248457474 T/G cg13385794 chr1:248469461 NA 0.38 6.55 0.34 2.16e-10 Common traits (Other); CRC cis rs7552404 0.690 rs12723575 chr1:76335203 T/C cg03433033 chr1:76189801 ACADM -0.65 -8.51 -0.42 6.21e-16 Blood metabolite levels;Acylcarnitine levels; CRC cis rs185694 1.000 rs846498 chr13:30900541 A/G cg04551440 chr13:30881194 KATNAL1 -0.61 -6.32 -0.33 8.68e-10 Antineutrophil cytoplasmic antibody-associated vasculitis; CRC cis rs2204008 0.653 rs11182569 chr12:38572452 G/A cg13010199 chr12:38710504 ALG10B 0.45 5.78 0.3 1.72e-8 Bladder cancer; CRC cis rs28386778 0.863 rs1376110 chr17:61779927 A/C cg06873352 chr17:61820015 STRADA 0.74 12.91 0.58 3.82e-31 Prudent dietary pattern; CRC cis rs875971 0.545 rs10950036 chr7:65818228 G/T cg18876405 chr7:65276391 NA 0.45 6.31 0.33 8.87e-10 Aortic root size; CRC cis rs2576037 0.796 rs2247021 chr18:44578794 A/C cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.41 6.56 0.34 2.13e-10 Personality dimensions; CRC cis rs34779708 0.801 rs34592588 chr10:35540134 A/G cg03585969 chr10:35415529 CREM 0.58 7.35 0.38 1.56e-12 Inflammatory bowel disease;Crohn's disease; CRC cis rs9322193 0.516 rs1999632 chr6:150187873 C/T cg07701084 chr6:150067640 NUP43 0.49 6.07 0.32 3.53e-9 Lung cancer; CRC cis rs7258465 0.931 rs875396 chr19:18611147 A/G cg10790698 chr19:18539756 SSBP4 -0.43 -8.4 -0.42 1.37e-15 Breast cancer; CRC cis rs6893300 0.524 rs10516146 chr5:179166974 A/G cg14593053 chr5:179126677 CANX 0.5 7.93 0.4 3.39e-14 Resting heart rate; CRC cis rs11599315 0.507 rs12220555 chr10:1341858 C/T cg09624528 chr10:1369823 ADARB2 0.4 5.94 0.31 7.16e-9 Thiazide-induced adverse metabolic effects in hypertensive patients; CRC trans rs1814175 0.817 rs28544182 chr11:50049577 G/T cg15704280 chr7:45808275 SEPT13 -1.0 -20.79 -0.75 6.66e-62 Height; CRC cis rs9911578 1.000 rs12449365 chr17:56600660 C/G cg05425664 chr17:57184151 TRIM37 0.51 8.14 0.41 8.43e-15 Intelligence (multi-trait analysis); CRC cis rs10782582 0.586 rs11161902 chr1:76392498 C/G cg03433033 chr1:76189801 ACADM -0.41 -5.87 -0.31 1.08e-8 Daytime sleep phenotypes; CRC cis rs875971 0.862 rs11763189 chr7:65983529 G/A cg12463550 chr7:65579703 CRCP 0.49 6.89 0.36 2.86e-11 Aortic root size; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg27649522 chr12:12877729 APOLD1 0.48 6.28 0.33 1.04e-9 Thyroid stimulating hormone; CRC cis rs861020 0.630 rs616544 chr1:210007368 T/C cg05527609 chr1:210001259 C1orf107 0.77 10.67 0.51 5.14e-23 Orofacial clefts; CRC cis rs7666738 0.830 rs6829567 chr4:99047340 T/C cg05340658 chr4:99064831 C4orf37 0.6 9.35 0.46 1.4e-18 Colonoscopy-negative controls vs population controls; CRC cis rs9549367 0.713 rs4907599 chr13:113861441 C/T cg00898013 chr13:113819073 PROZ 0.53 7.92 0.4 3.74e-14 Platelet distribution width; CRC cis rs4638749 0.588 rs13401731 chr2:108885340 C/T cg25838818 chr2:108905173 SULT1C2 -0.38 -6.76 -0.35 6.27e-11 Blood pressure; CRC trans rs7615952 0.558 rs7641353 chr3:125339879 T/C cg03844506 chr4:4109441 NA -0.51 -7.55 -0.38 4.42e-13 Blood pressure (smoking interaction); CRC cis rs10924970 0.967 rs7512798 chr1:235356425 C/A cg26050004 chr1:235667680 B3GALNT2 0.39 5.66 0.3 3.28e-8 Asthma; CRC cis rs8062405 1.000 rs7498665 chr16:28883241 A/G cg16576597 chr16:28551801 NUPR1 0.48 6.82 0.35 4.39e-11 Cognitive ability (multi-trait analysis);Cognitive ability; CRC cis rs9903692 0.954 rs8077860 chr17:46185335 G/A cg21215337 chr17:46176117 CBX1 -0.43 -7.95 -0.4 2.95e-14 Pulse pressure; CRC cis rs875971 0.862 rs6978028 chr7:65886300 G/C cg00343986 chr7:65444356 GUSB 0.45 6.22 0.32 1.52e-9 Aortic root size; CRC cis rs6088590 1.000 rs2378256 chr20:33292127 G/C cg24642439 chr20:33292090 TP53INP2 0.61 11.0 0.52 3.59e-24 Coronary artery disease; CRC trans rs17685 0.753 rs6465000 chr7:75787417 G/A cg19862616 chr7:65841803 NCRNA00174 0.98 18.08 0.71 3.12e-51 Coffee consumption;Coffee consumption (cups per day); CRC cis rs2396545 0.591 rs12802200 chr11:566936 C/A cg09218773 chr11:619014 MUPCDH -0.44 -5.98 -0.31 5.82e-9 Systemic lupus erythematosus and Systemic sclerosis; CRC cis rs2075371 1.000 rs2504 chr7:133979545 A/T cg20476274 chr7:133979776 SLC35B4 0.81 14.73 0.63 4.56e-38 Mean platelet volume; CRC cis rs7737355 0.947 rs31587 chr5:131000711 A/T cg06307176 chr5:131281290 NA 0.41 5.89 0.31 9.38e-9 Life satisfaction; CRC cis rs17818399 0.788 rs17818315 chr2:46818992 C/T cg21681030 chr2:46777652 RHOQ 0.44 6.3 0.33 9.6e-10 Height; CRC cis rs9303280 0.587 rs35123741 chr17:38092930 A/G cg24910161 chr17:38119198 GSDMA -0.32 -5.71 -0.3 2.59e-8 Self-reported allergy; CRC cis rs67311347 0.955 rs6599100 chr3:40447362 C/T cg09455208 chr3:40491958 NA 0.43 8.88 0.44 4.42e-17 Renal cell carcinoma; CRC cis rs12142240 0.698 rs7515598 chr1:46818479 C/T cg00530320 chr1:46809349 NSUN4 0.58 7.93 0.4 3.43e-14 Menopause (age at onset); CRC cis rs4638749 0.677 rs13022268 chr2:108837320 A/G cg25838818 chr2:108905173 SULT1C2 -0.33 -5.61 -0.3 4.35e-8 Blood pressure; CRC cis rs56235845 0.964 rs11746443 chr5:176798306 G/A cg05207973 chr5:176823642 SLC34A1 0.48 7.52 0.38 5.16e-13 Hemoglobin concentration;Hematocrit; CRC trans rs10060123 1.000 rs10072436 chr5:125685429 G/T ch.6.113866684R chr6:113759991 NA -0.38 -5.97 -0.31 6.31e-9 Visceral adipose tissue adjusted for BMI;Visceral adipose tissue; CRC cis rs4561483 0.673 rs28279 chr16:11968555 A/C cg08843971 chr16:11963173 GSPT1 0.62 9.46 0.46 6e-19 Testicular germ cell tumor; CRC trans rs7615952 0.558 rs7641353 chr3:125339879 T/C cg07211511 chr3:129823064 LOC729375 -0.67 -9.4 -0.46 9.35e-19 Blood pressure (smoking interaction); CRC cis rs4690686 0.500 rs11728314 chr4:177268373 G/A cg17059388 chr4:177262070 NA 0.38 5.74 0.3 2.14e-8 Essential tremor; CRC cis rs7493 1.000 rs2286232 chr7:95039445 C/T cg01874867 chr7:94954059 PON1 -0.49 -6.36 -0.33 6.6e-10 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs7737355 0.898 rs2161414 chr5:131063073 C/T cg06307176 chr5:131281290 NA 0.41 6.13 0.32 2.5e-9 Life satisfaction; CRC cis rs3018066 0.666 rs79928816 chr4:107063479 C/A cg01869342 chr4:106983673 TBCK 0.48 6.15 0.32 2.25e-9 Cancer; CRC cis rs826838 0.651 rs1843896 chr12:38612913 G/C cg26384229 chr12:38710491 ALG10B 0.55 7.49 0.38 6.4e-13 Heart rate; CRC cis rs6964587 0.869 rs6946764 chr7:91539003 A/G cg17063962 chr7:91808500 NA -0.74 -12.31 -0.56 6.62e-29 Breast cancer; CRC cis rs2576037 0.796 rs2571031 chr18:44577063 T/C cg07416455 chr18:44543612 TCEB3CL;KATNAL2 0.42 6.12 0.32 2.71e-9 Personality dimensions; CRC cis rs17376456 0.877 rs2085960 chr5:93399934 A/G cg09848695 chr5:92956644 FAM172A;MIR2277 0.61 5.68 0.3 2.95e-8 Diabetic retinopathy; CRC trans rs3001167 0.609 rs4642873 chr1:194553723 A/G cg22004422 chr13:113740730 MCF2L -0.62 -6.31 -0.33 8.84e-10 Obesity-related traits; CRC cis rs9858542 0.953 rs9818590 chr3:49525096 A/G cg03060546 chr3:49711283 APEH -0.47 -6.6 -0.34 1.63e-10 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs7692995 1.000 rs7698271 chr4:18019413 C/T cg08925142 chr4:18023851 LCORL -0.51 -5.81 -0.3 1.5e-8 Height; CRC cis rs55788414 0.932 rs35066366 chr16:81185280 G/A cg06400318 chr16:81190750 PKD1L2 -0.59 -6.76 -0.35 6.2e-11 Left ventricular obstructive tract defect (maternal effect); CRC cis rs2976388 0.609 rs2572899 chr8:143785549 A/G cg04969067 chr8:143858791 LYNX1 0.44 7.51 0.38 5.59e-13 Urinary tract infection frequency; CRC trans rs2228479 0.850 rs45524643 chr16:89815824 G/A cg24644049 chr4:85504048 CDS1 0.9 7.46 0.38 7.69e-13 Skin colour saturation; CRC cis rs62064224 0.553 rs9896320 chr17:30689814 G/A cg09324608 chr17:30823087 MYO1D 0.33 5.64 0.3 3.69e-8 Schizophrenia; CRC cis rs4654899 0.802 rs76122612 chr1:21243059 C/T cg02927042 chr1:21476669 EIF4G3 -0.5 -8.0 -0.4 2.15e-14 Superior frontal gyrus grey matter volume; CRC cis rs56235845 0.694 rs4532376 chr5:176774403 G/A cg06060754 chr5:176797920 RGS14 0.54 8.44 0.42 9.9e-16 Hemoglobin concentration;Hematocrit; CRC cis rs7666738 0.830 rs35938349 chr4:98974998 T/C cg05340658 chr4:99064831 C4orf37 0.6 9.35 0.46 1.41e-18 Colonoscopy-negative controls vs population controls; CRC cis rs9435341 0.930 rs2232015 chr1:107599258 A/T cg11070056 chr1:107600091 PRMT6 0.42 6.05 0.32 3.95e-9 Facial morphology (factor 21, depth of nasal alae); CRC cis rs10991814 0.920 rs3827826 chr9:94030185 G/A cg14446406 chr9:93919335 NA 0.58 6.41 0.33 5.03e-10 Neutrophil percentage of granulocytes; CRC cis rs2239547 0.603 rs7644973 chr3:53082937 C/T cg18404041 chr3:52824283 ITIH1 -0.33 -5.93 -0.31 7.83e-9 Schizophrenia; CRC cis rs270601 0.710 rs4705852 chr5:131602807 A/G cg24060327 chr5:131705240 SLC22A5 -0.4 -6.22 -0.32 1.49e-9 Acylcarnitine levels; CRC cis rs9443645 0.869 rs7756858 chr6:79619968 A/G cg05283184 chr6:79620031 NA -0.56 -8.84 -0.44 5.75e-17 Intelligence (multi-trait analysis); CRC trans rs7395662 1.000 rs11039868 chr11:48622146 T/C cg21153622 chr11:89784906 NA -0.45 -7.22 -0.37 3.57e-12 HDL cholesterol; CRC cis rs853679 0.550 rs1225599 chr6:28165190 C/T cg03623178 chr6:28175578 NA 1.0 15.19 0.64 7.35e-40 Depression; CRC trans rs1814175 0.616 rs28417656 chr11:50040152 C/T cg15704280 chr7:45808275 SEPT13 -0.94 -17.39 -0.69 1.77e-48 Height; CRC cis rs2288073 0.619 rs6713263 chr2:24375463 A/G cg06627628 chr2:24431161 ITSN2 -0.44 -6.42 -0.33 4.74e-10 Venous thromboembolism (SNP x SNP interaction); CRC cis rs7246657 0.941 rs7259618 chr19:37750719 G/A cg23950597 chr19:37808831 NA -0.54 -6.25 -0.33 1.3e-9 Coronary artery calcification; CRC trans rs9903692 0.909 rs9899275 chr17:46129315 C/T cg13910583 chr8:56987998 RPS20 -0.44 -5.99 -0.31 5.63e-9 Pulse pressure; CRC cis rs6743376 0.556 rs2515394 chr2:113817765 C/T cg09040174 chr2:113837401 NA 0.44 6.37 0.33 6.46e-10 Inflammatory biomarkers; CRC cis rs3733585 0.699 rs6449179 chr4:9969117 G/A cg11266682 chr4:10021025 SLC2A9 -0.46 -9.42 -0.46 8.4e-19 Cleft plate (environmental tobacco smoke interaction); CRC cis rs644799 0.930 rs631099 chr11:95563482 T/C cg03916912 chr11:95522834 CEP57;FAM76B 0.95 18.38 0.71 2.03e-52 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs11676348 0.791 rs4133195 chr2:218951245 A/G cg00012203 chr2:219082015 ARPC2 0.39 5.85 0.31 1.21e-8 Ulcerative colitis; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg26399773 chr5:74633655 HMGCR 0.35 5.97 0.31 6.06e-9 Liver disease severity in Alagille syndrome; CRC cis rs3750965 1.000 rs3750965 chr11:68840160 A/G cg06818126 chr11:68850279 TPCN2 -0.49 -6.95 -0.36 1.99e-11 Hair color; CRC cis rs2153535 0.580 rs9393022 chr6:8466588 T/C cg21535247 chr6:8435926 SLC35B3 0.49 7.38 0.38 1.28e-12 Motion sickness; CRC cis rs881375 0.678 rs10818488 chr9:123705087 A/G cg09419670 chr9:123605666 PSMD5;LOC253039 0.44 6.7 0.35 8.93e-11 Rheumatoid arthritis; CRC trans rs4295623 0.789 rs12541318 chr8:11594970 G/T cg06636001 chr8:8085503 FLJ10661 -0.45 -6.58 -0.34 1.89e-10 Morning vs. evening chronotype; CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg09400194 chr10:81107848 PPIF -0.5 -6.03 -0.32 4.48e-9 Diisocyanate-induced asthma; CRC cis rs3768617 0.510 rs7525917 chr1:183065406 A/G ch.1.3577855R chr1:183094577 LAMC1 0.81 13.42 0.59 4.81e-33 Fuchs's corneal dystrophy; CRC cis rs7727544 0.716 rs72793283 chr5:131566941 G/A cg18758796 chr5:131593413 PDLIM4 0.36 6.6 0.34 1.64e-10 Blood metabolite levels; CRC cis rs3106136 0.934 rs2902979 chr4:95177874 C/G cg11021082 chr4:95130006 SMARCAD1 -0.46 -7.17 -0.37 4.89e-12 Capecitabine sensitivity; CRC cis rs10883723 0.810 rs2281879 chr10:104268877 C/G cg04362960 chr10:104952993 NT5C2 -0.46 -6.51 -0.34 2.83e-10 Allergic disease (asthma, hay fever or eczema); CRC cis rs524281 0.773 rs11227447 chr11:66048280 G/C cg14036092 chr11:66035641 RAB1B -0.54 -5.97 -0.31 6.14e-9 Electroencephalogram traits; CRC cis rs7666738 0.800 rs13107586 chr4:99028788 G/C cg17366294 chr4:99064904 C4orf37 0.44 7.48 0.38 6.96e-13 Colonoscopy-negative controls vs population controls; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg15503799 chr1:156737481 PRCC 0.42 6.08 0.32 3.35e-9 Intelligence (multi-trait analysis); CRC trans rs7301826 0.627 rs7315707 chr12:131272819 A/G cg21271767 chr15:63449808 RPS27L 0.46 6.01 0.31 4.81e-9 Plasma plasminogen activator levels; CRC trans rs8002861 0.905 rs12873099 chr13:44396247 G/A cg17145862 chr1:211918768 LPGAT1 -0.72 -12.99 -0.58 1.97e-31 Leprosy; CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg01283712 chr14:106919294 NA -0.35 -6.01 -0.31 5.04e-9 Obesity-related traits; CRC cis rs9487051 0.872 rs1521908 chr6:109613986 T/C cg21918786 chr6:109611834 NA -0.44 -8.04 -0.41 1.61e-14 Reticulocyte fraction of red cells; CRC trans rs875971 0.660 rs2191268 chr7:66110224 C/T cg12590005 chr6:35997326 MAPK14 -0.35 -6.05 -0.32 3.86e-9 Aortic root size; CRC cis rs7811142 0.943 rs11769886 chr7:99998607 G/A cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.16 15.33 0.65 2.11e-40 Platelet count; CRC cis rs394563 0.591 rs6570964 chr6:149691859 G/A cg03678062 chr6:149772716 ZC3H12D 0.34 6.21 0.32 1.64e-9 Dupuytren's disease; CRC cis rs3789045 0.774 rs4252733 chr1:204516918 C/T cg17419461 chr1:204415978 PIK3C2B -0.54 -7.61 -0.39 2.91e-13 Educational attainment (college completion); CRC cis rs11098499 0.908 rs7696649 chr4:120322177 G/A cg24375607 chr4:120327624 NA 0.5 7.69 0.39 1.74e-13 Corneal astigmatism; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg25721516 chr17:42276931 ATXN7L3 -0.41 -6.1 -0.32 2.92e-9 Myopia (pathological); CRC cis rs7618501 0.669 rs7634084 chr3:49949834 A/T cg05623727 chr3:50126028 RBM5 0.45 7.55 0.38 4.33e-13 Intelligence (multi-trait analysis); CRC cis rs892961 1.000 rs11653743 chr17:75401923 C/A cg05865280 chr17:75406074 SEPT9 0.6 12.37 0.56 3.93e-29 Airflow obstruction; CRC cis rs453193 0.677 rs2630708 chr2:8447185 A/G cg12167548 chr2:8464763 NA 0.29 5.75 0.3 2.02e-8 Granulocyte percentage of myeloid white cells; CRC cis rs2898681 0.521 rs115874483 chr4:53728272 G/A cg21521518 chr4:53727714 RASL11B 0.4 5.93 0.31 7.81e-9 Optic nerve measurement (cup area); CRC cis rs8114671 0.562 rs1060615 chr20:33478381 C/T cg07148914 chr20:33460835 GGT7 -0.39 -6.23 -0.32 1.44e-9 Height; CRC cis rs2153535 0.580 rs2184583 chr6:8447808 A/G cg21535247 chr6:8435926 SLC35B3 0.5 7.5 0.38 6.06e-13 Motion sickness; CRC cis rs3617 0.625 rs6769789 chr3:52874446 C/T cg07507251 chr3:52567010 NT5DC2 -0.39 -5.99 -0.31 5.54e-9 Red blood cell count;Autism spectrum disorder or schizophrenia; CRC cis rs13082711 0.954 rs34772035 chr3:27468872 C/G cg02860705 chr3:27208620 NA 0.63 8.43 0.42 1.07e-15 Systolic blood pressure;Diastolic blood pressure;Blood pressure; CRC cis rs4862750 0.914 rs1346126 chr4:187876404 T/C cg03452623 chr4:187889614 NA -0.89 -20.41 -0.75 2.14e-60 Lobe attachment (rater-scored or self-reported); CRC cis rs57590327 0.503 rs11711024 chr3:81910207 T/C cg07356753 chr3:81810745 GBE1 -0.58 -7.79 -0.39 8.57e-14 Extraversion; CRC cis rs25645 0.502 rs7223318 chr17:38108553 G/C cg26162295 chr17:38119207 GSDMA -0.34 -5.7 -0.3 2.68e-8 Myeloid white cell count; CRC cis rs9372498 0.536 rs9489447 chr6:118900846 G/A cg01339444 chr6:118972232 C6orf204 0.53 6.01 0.31 5.01e-9 Diastolic blood pressure; CRC cis rs931127 0.719 rs2170082 chr11:65454795 A/G cg27068330 chr11:65405492 SIPA1 -0.4 -5.62 -0.3 4.13e-8 Systemic lupus erythematosus; CRC cis rs853679 0.550 rs1233699 chr6:28169158 A/T cg12273811 chr6:28175739 NA 0.76 10.83 0.51 1.43e-23 Depression; CRC cis rs7512552 0.582 rs834233 chr1:150354276 G/A cg15654264 chr1:150340011 RPRD2 0.57 8.24 0.41 4.18e-15 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); CRC cis rs9326248 1.000 rs664971 chr11:117070857 A/G cg20608306 chr11:116969690 SIK3 -0.31 -5.93 -0.31 7.75e-9 Blood protein levels; CRC trans rs67073037 0.955 rs3924271 chr2:29167692 G/A cg13899017 chr1:159158444 CADM3 -0.37 -6.14 -0.32 2.4e-9 Breast cancer;Breast cancer (estrogen-receptor negative); CRC cis rs6696846 0.765 rs3738155 chr1:205074424 C/T cg03948781 chr1:205179583 DSTYK 0.42 6.08 0.32 3.34e-9 Red blood cell count; CRC cis rs76793172 0.588 rs659444 chr19:46284947 T/C cg11657440 chr19:46296263 DMWD 0.56 5.63 0.3 3.78e-8 Eosinophil counts; CRC cis rs2153535 0.547 rs9505475 chr6:8542890 A/G cg21535247 chr6:8435926 SLC35B3 0.5 7.78 0.39 9.25e-14 Motion sickness; CRC cis rs10463316 0.928 rs4958451 chr5:150740007 T/C cg03212797 chr5:150827313 SLC36A1 -0.51 -7.8 -0.4 8.16e-14 Metabolite levels (Pyroglutamine); CRC cis rs10779751 0.881 rs2744815 chr1:11360957 C/T cg08854313 chr1:11322531 MTOR 0.7 10.47 0.5 2.5e-22 Body mass index; CRC cis rs6831352 0.734 rs12502237 chr4:100015675 G/A cg12011299 chr4:100065546 ADH4 0.44 8.68 0.43 1.83e-16 Alcohol dependence; CRC cis rs7762018 0.607 rs79355059 chr6:170062157 T/C cg19338460 chr6:170058176 WDR27 -1.21 -11.42 -0.53 1.14e-25 Thiazide-induced adverse metabolic effects in hypertensive patients; CRC cis rs910316 0.646 rs11546525 chr14:75537381 C/T cg08847533 chr14:75593920 NEK9 0.83 13.14 0.59 5.37e-32 Height; CRC cis rs6964587 0.872 rs57969083 chr7:91665627 A/T cg17063962 chr7:91808500 NA 0.83 14.67 0.63 7.46e-38 Breast cancer; CRC cis rs9611565 0.729 rs2413647 chr22:41907148 G/A cg06634786 chr22:41940651 POLR3H -0.71 -8.34 -0.42 2e-15 Vitiligo; CRC cis rs7927592 0.763 rs2513277 chr11:68360887 T/G cg16797656 chr11:68205561 LRP5 0.49 9.0 0.44 1.87e-17 Total body bone mineral density; CRC trans rs7615952 0.932 rs13314869 chr3:125644669 G/A cg02007433 chr3:129722099 NA -0.46 -6.23 -0.32 1.41e-9 Blood pressure (smoking interaction); CRC cis rs713587 0.875 rs6746013 chr2:25143649 C/G cg22495460 chr2:25135724 ADCY3 -0.79 -14.28 -0.62 2.41e-36 Body mass index in non-asthmatics; CRC cis rs2811415 0.597 rs9849210 chr3:127779633 G/T cg13719885 chr3:127795394 NA -0.39 -5.95 -0.31 6.69e-9 Lung function (FEV1/FVC); CRC cis rs67311347 1.000 rs954589 chr3:40444545 C/T cg09455208 chr3:40491958 NA 0.47 8.93 0.44 3.11e-17 Renal cell carcinoma; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg00088299 chr4:2538934 NA 0.47 6.15 0.32 2.22e-9 Anxiety disorder; CRC trans rs17685 0.712 rs6954569 chr7:75738885 T/A cg19862616 chr7:65841803 NCRNA00174 0.98 18.34 0.71 2.87e-52 Coffee consumption;Coffee consumption (cups per day); CRC cis rs8180040 0.620 rs2305635 chr3:47043622 G/A cg10298567 chr3:47292165 KIF9 0.4 6.27 0.33 1.12e-9 Colorectal cancer; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg15309264 chr2:58274034 VRK2 0.46 6.05 0.32 4.03e-9 Thyroid stimulating hormone; CRC cis rs798554 1.000 rs798550 chr7:2760609 A/G cg05055821 chr7:2758924 NA -0.35 -5.61 -0.3 4.27e-8 Height; CRC cis rs6546324 0.625 rs1430789 chr2:67866370 T/C cg15745817 chr2:67799979 NA -0.55 -9.54 -0.47 3.34e-19 Endometriosis; CRC cis rs796364 1.000 rs281774 chr2:200814572 C/T cg25936922 chr2:200820526 C2orf60;C2orf47 0.7 7.64 0.39 2.33e-13 Schizophrenia; CRC cis rs9660180 0.935 rs2180311 chr1:1748734 T/C cg13866156 chr1:1669148 SLC35E2 -0.63 -9.83 -0.48 3.56e-20 Body mass index; CRC cis rs1005277 0.579 rs2474580 chr10:38398713 G/A cg25427524 chr10:38739819 LOC399744 -0.77 -13.64 -0.6 6.83e-34 Extrinsic epigenetic age acceleration; CRC cis rs875971 0.545 rs73136346 chr7:65566082 A/G cg02869306 chr7:64672164 INTS4L1 0.44 6.26 0.33 1.17e-9 Aortic root size; CRC cis rs4713118 0.513 rs149989 chr6:27998184 T/A cg25164649 chr6:28176230 NA 0.61 8.88 0.44 4.57e-17 Parkinson's disease; CRC cis rs7249142 0.562 rs2314035 chr19:19284920 T/C cg12558012 chr19:19281197 LOC729991-MEF2B;MEF2B 0.53 8.36 0.42 1.81e-15 IgG glycosylation; CRC cis rs10504229 0.953 rs57669205 chr8:58172253 T/C cg02290350 chr8:58132656 NA -0.42 -5.94 -0.31 7.43e-9 Developmental language disorder (linguistic errors); CRC cis rs875971 0.737 rs7803424 chr7:65880605 T/C cg00343986 chr7:65444356 GUSB 0.43 6.3 0.33 9.66e-10 Aortic root size; CRC cis rs4658101 0.653 rs11165002 chr1:92048966 G/T cg24006770 chr1:92056542 NA -0.46 -6.7 -0.35 9.12e-11 Optic disc area;Vertical cup-disc ratio; CRC cis rs2243480 0.803 rs55700941 chr7:65389800 T/A cg25985355 chr7:65971099 NA -0.48 -5.64 -0.3 3.67e-8 Diabetic kidney disease; CRC cis rs3096299 0.933 rs3096297 chr16:89453155 T/G cg01788221 chr16:89496183 ANKRD11 -0.39 -5.87 -0.31 1.06e-8 Multiple myeloma (IgH translocation); CRC cis rs853679 0.517 rs4713144 chr6:28106790 C/G cg12172441 chr6:28176163 NA 0.62 7.4 0.38 1.17e-12 Depression; CRC trans rs7267979 0.932 rs372678 chr20:25465248 G/A cg17903999 chr18:56338584 MALT1 -0.4 -6.8 -0.35 4.96e-11 Liver enzyme levels (alkaline phosphatase); CRC cis rs1218582 0.710 rs9794000 chr1:154878876 T/A cg03351412 chr1:154909251 PMVK 0.55 8.86 0.44 5.16e-17 Prostate cancer; CRC cis rs877282 0.853 rs10904545 chr10:757100 G/A cg17470449 chr10:769945 NA 0.63 8.25 0.41 3.89e-15 Uric acid levels; CRC cis rs7772486 0.521 rs9485017 chr6:146023326 C/T cg05347473 chr6:146136440 FBXO30 0.43 6.41 0.33 5.11e-10 Lobe attachment (rater-scored or self-reported); CRC cis rs7020830 0.823 rs7019699 chr9:37125081 C/A cg14294708 chr9:37120828 ZCCHC7 1.21 28.58 0.84 3.59e-91 Schizophrenia; CRC cis rs2576037 0.583 rs487386 chr18:44377004 A/G cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.63 10.71 0.51 3.72e-23 Personality dimensions; CRC cis rs4481887 0.893 rs4244186 chr1:248493319 A/G cg00666640 chr1:248458726 OR2T12 0.48 8.08 0.41 1.24e-14 Common traits (Other); CRC cis rs10751667 0.961 rs7395928 chr11:952605 T/G cg01483505 chr11:975446 AP2A2 0.39 5.92 0.31 8.04e-9 Alzheimer's disease (late onset); CRC cis rs763121 0.853 rs5995610 chr22:39064681 C/T cg06022373 chr22:39101656 GTPBP1 0.8 12.71 0.57 2.19e-30 Menopause (age at onset); CRC cis rs7618915 0.501 rs11714030 chr3:52765882 C/T cg05573699 chr3:52720067 GNL3;PBRM1 -0.45 -6.67 -0.35 1.05e-10 Bipolar disorder; CRC cis rs2982552 0.844 rs3020347 chr6:152056962 T/G cg22157087 chr6:152012887 ESR1 0.37 5.86 0.31 1.1e-8 Bone properties (heel); CRC cis rs736408 0.609 rs13087772 chr3:52782274 T/G cg18099408 chr3:52552593 STAB1 -0.44 -7.21 -0.37 3.86e-12 Bipolar disorder; CRC cis rs7224314 1.000 rs62084076 chr17:65383102 G/A cg01507342 chr17:65387096 PITPNC1 -0.57 -8.15 -0.41 7.92e-15 Diisocyanate-induced asthma; CRC cis rs34172651 0.917 rs172066 chr16:24756449 C/T cg06505273 chr16:24850292 NA 0.37 5.83 0.31 1.32e-8 Intelligence (multi-trait analysis); CRC cis rs10931896 0.531 rs295118 chr2:201144004 C/T cg23649088 chr2:200775458 C2orf69 0.44 6.07 0.32 3.5e-9 Systolic blood pressure; CRC cis rs9486715 1.000 rs3798297 chr6:97062835 C/T cg06623918 chr6:96969491 KIAA0776 -0.97 -17.1 -0.69 2.36e-47 Headache; CRC cis rs2455601 0.638 rs11042148 chr11:9008674 A/G cg09997546 chr11:8931473 C11orf17;ST5 -0.48 -6.43 -0.33 4.4e-10 Schizophrenia; CRC cis rs1448094 0.842 rs10863155 chr12:86446416 T/C cg02569458 chr12:86230093 RASSF9 -0.39 -6.48 -0.34 3.31e-10 Major depressive disorder; CRC cis rs11212617 0.967 rs4754324 chr11:108325448 G/A cg01991180 chr11:108092276 ATM;NPAT 0.41 5.9 0.31 9.28e-9 Response to metformin in type 2 diabetes (glycemic); CRC cis rs7131987 0.650 rs4331146 chr12:29440083 G/T cg09582351 chr12:29534625 ERGIC2 -0.33 -7.12 -0.37 6.69e-12 QT interval; CRC cis rs3796352 1.000 rs33999310 chr3:52883332 G/A cg06204229 chr3:52865917 ITIH4 0.55 6.47 0.34 3.64e-10 Immune reponse to smallpox (secreted IL-2); CRC cis rs7584330 0.504 rs11883500 chr2:238434434 C/T cg14458575 chr2:238380390 NA 0.53 7.03 0.36 1.18e-11 Prostate cancer; CRC trans rs11039798 0.588 rs11039781 chr11:48523085 T/G cg15704280 chr7:45808275 SEPT13 0.63 6.45 0.34 4.08e-10 Axial length; CRC cis rs908922 0.676 rs1337338 chr1:152511885 G/A cg23254163 chr1:152506842 NA 0.45 8.85 0.44 5.3e-17 Hair morphology; CRC cis rs2760061 0.819 rs1745416 chr1:228204497 G/A cg18477163 chr1:228402036 OBSCN 0.4 6.76 0.35 6.24e-11 Diastolic blood pressure; CRC cis rs10991814 0.920 rs75120664 chr9:94117275 A/C cg14446406 chr9:93919335 NA 0.59 6.66 0.34 1.13e-10 Neutrophil percentage of granulocytes; CRC cis rs372883 0.563 rs1153293 chr21:30691325 C/T cg08807101 chr21:30365312 RNF160 0.6 8.35 0.42 1.92e-15 Pancreatic cancer; CRC cis rs12188164 0.561 rs2251843 chr5:457955 C/T cg14122633 chr5:456516 EXOC3 0.4 7.06 0.36 9.65e-12 Cystic fibrosis severity; CRC cis rs2223471 0.870 rs2744498 chr6:50754851 A/C cg03432817 chr6:50765336 NA 0.38 6.02 0.32 4.62e-9 Subcutaneous adipose tissue; CRC cis rs13191362 1.000 rs55847707 chr6:163003414 G/A cg21926612 chr6:163149169 PACRG;PARK2 0.8 11.25 0.53 4.59e-25 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs7772486 0.790 rs1133832 chr6:146205604 C/T cg23711669 chr6:146136114 FBXO30 -0.64 -10.94 -0.52 5.7e-24 Lobe attachment (rater-scored or self-reported); CRC cis rs875971 0.660 rs10263935 chr7:66096028 A/G cg00343986 chr7:65444356 GUSB 0.52 7.97 0.4 2.56e-14 Aortic root size; CRC cis rs11711311 0.668 rs11718061 chr3:113341826 C/T cg06805542 chr3:113465803 ATP6V1A;NAA50 0.53 7.0 0.36 1.43e-11 IgG glycosylation; CRC cis rs4713118 0.516 rs4713142 chr6:28106347 T/G cg12963246 chr6:28129442 ZNF389 0.49 5.78 0.3 1.73e-8 Parkinson's disease; CRC cis rs10876993 0.890 rs2640630 chr12:58067267 T/C cg18357645 chr12:58087776 OS9 0.59 8.25 0.41 3.96e-15 Celiac disease or Rheumatoid arthritis; CRC cis rs17376456 0.825 rs12153021 chr5:93073913 A/G cg25358565 chr5:93447407 FAM172A 1.0 9.41 0.46 9.08e-19 Diabetic retinopathy; CRC cis rs5750830 0.594 rs9611169 chr22:39783027 C/T cg05872129 chr22:39784769 NA -0.55 -9.93 -0.48 1.73e-20 Intelligence (multi-trait analysis); CRC cis rs6496667 0.865 rs7161926 chr15:90888962 A/G cg04176472 chr15:90893244 GABARAPL3 0.58 6.84 0.35 3.82e-11 Rheumatoid arthritis; CRC cis rs10489525 0.583 rs6691374 chr1:115642818 T/C cg01522456 chr1:115632236 TSPAN2 0.65 9.64 0.47 1.6e-19 Autism; CRC cis rs11212617 0.805 rs10890821 chr11:108022061 A/T cg01991180 chr11:108092276 ATM;NPAT 0.41 6.1 0.32 2.98e-9 Response to metformin in type 2 diabetes (glycemic); CRC cis rs7527798 0.592 rs2181694 chr1:207826776 G/A cg21110645 chr1:207815933 NA -0.43 -6.99 -0.36 1.56e-11 Erythrocyte sedimentation rate; CRC cis rs6545883 0.931 rs778765 chr2:61786385 A/T cg15711740 chr2:61764176 XPO1 -0.52 -7.12 -0.37 6.72e-12 Tuberculosis; CRC trans rs1728785 1.000 rs11647432 chr16:68565426 C/T cg04657470 chr2:198365150 HSPE1;HSPD1 0.57 6.78 0.35 5.72e-11 Ulcerative colitis; CRC cis rs12142240 0.698 rs41294476 chr1:46818374 C/A cg00530320 chr1:46809349 NSUN4 0.58 7.93 0.4 3.43e-14 Menopause (age at onset); CRC cis rs41005 1.000 rs35398717 chr2:8115041 A/T cg03155496 chr2:8117019 LOC339788 -0.39 -6.71 -0.35 8.29e-11 Response to anti-TNF therapy in rheumatoid arthritis; CRC cis rs12908161 0.960 rs11633450 chr15:85307287 C/T cg11189052 chr15:85197271 WDR73 0.54 7.55 0.38 4.31e-13 Schizophrenia; CRC cis rs10540 1.000 rs10540 chr11:494662 G/A cg15790184 chr11:494944 RNH1 0.6 6.18 0.32 1.85e-9 Body mass index; CRC cis rs1153858 0.943 rs67045941 chr15:45677011 A/G cg14582100 chr15:45693742 SPATA5L1 0.28 5.72 0.3 2.41e-8 Homoarginine levels; CRC cis rs561341 0.941 rs736678 chr17:30347423 G/T cg12193833 chr17:30244370 NA -0.74 -8.79 -0.44 8.61e-17 Hip circumference adjusted for BMI; CRC cis rs9398803 0.865 rs4895808 chr6:126781434 C/T cg19875578 chr6:126661172 C6orf173 0.43 5.94 0.31 7.11e-9 Male-pattern baldness; CRC trans rs6703335 0.870 rs10803142 chr1:243598234 A/G cg00774050 chr4:73935472 COX18 0.4 6.04 0.32 4.06e-9 Schizophrenia;Schizophrenia, schizoaffective disorder or bipolar disorder; CRC cis rs11148252 0.624 rs6561682 chr13:53266297 A/G cg12458913 chr13:53173898 NA -0.5 -7.15 -0.37 5.81e-12 Lewy body disease; CRC cis rs9858542 0.953 rs3811697 chr3:49590770 C/T cg03060546 chr3:49711283 APEH -0.47 -6.51 -0.34 2.73e-10 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs1862618 0.853 rs252909 chr5:56121131 T/C cg24531977 chr5:56204891 C5orf35 -0.8 -10.78 -0.51 2.06e-23 Initial pursuit acceleration; CRC cis rs11741688 0.557 rs6898923 chr5:178330559 C/T cg20935368 chr5:178288625 ZNF354B 0.43 7.01 0.36 1.32e-11 Sleep duration; CRC cis rs4665809 0.652 rs10779956 chr2:26405985 A/G cg22920501 chr2:26401640 FAM59B -0.85 -11.89 -0.55 2.24e-27 Gut microbiome composition (summer); CRC cis rs6570726 0.791 rs4332001 chr6:145934841 T/C cg23711669 chr6:146136114 FBXO30 0.65 10.71 0.51 3.64e-23 Lobe attachment (rater-scored or self-reported); CRC cis rs6570726 1.000 rs441477 chr6:145848243 C/T cg23711669 chr6:146136114 FBXO30 0.69 12.24 0.56 1.24e-28 Lobe attachment (rater-scored or self-reported); CRC cis rs765787 0.530 rs11070451 chr15:45533541 T/C cg24006582 chr15:45444508 DUOX1 -0.57 -8.79 -0.44 8.5e-17 Uric acid levels; CRC trans rs1005277 0.579 rs2504140 chr10:38387579 T/G cg11292332 chr7:45801988 SEPT13 -0.35 -6.26 -0.33 1.18e-9 Extrinsic epigenetic age acceleration; CRC cis rs11122272 0.735 rs2790876 chr1:231536033 C/T cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.57 -8.6 -0.43 3.21e-16 Hemoglobin concentration; CRC cis rs2032447 0.802 rs199755 chr6:25990367 G/A cg27635394 chr6:26043820 HIST1H2BB 0.43 6.22 0.32 1.53e-9 Intelligence (multi-trait analysis); CRC cis rs939574 0.790 rs72955452 chr2:220101783 C/T cg00496455 chr2:220118770 TUBA4A;TUBA4B 0.88 8.03 0.4 1.71e-14 Platelet distribution width; CRC cis rs9311474 0.607 rs13076398 chr3:52573096 G/A cg18591801 chr3:52553433 STAB1 -0.3 -5.63 -0.3 3.78e-8 Electroencephalogram traits; CRC cis rs5769707 0.681 rs4824068 chr22:50024801 G/A cg20744362 chr22:50050164 C22orf34 0.33 5.98 0.31 5.77e-9 Monocyte count;Monocyte percentage of white cells; CRC cis rs9291683 0.507 rs3775940 chr4:10025163 A/T cg11266682 chr4:10021025 SLC2A9 0.52 10.84 0.51 1.24e-23 Bone mineral density; CRC cis rs5769765 0.819 rs9616379 chr22:50312035 C/T cg02269571 chr22:50332266 NA -0.62 -8.06 -0.41 1.39e-14 Schizophrenia; CRC cis rs1218582 0.772 rs10908445 chr1:154849590 A/G cg16680214 chr1:154839983 KCNN3 0.47 9.33 0.46 1.62e-18 Prostate cancer; CRC cis rs7618915 0.524 rs2028216 chr3:52680823 C/T cg05573699 chr3:52720067 GNL3;PBRM1 -0.45 -6.32 -0.33 8.47e-10 Bipolar disorder; CRC cis rs10504229 0.906 rs56130194 chr8:58197061 C/A cg24829409 chr8:58192753 C8orf71 -0.67 -8.67 -0.43 1.96e-16 Developmental language disorder (linguistic errors); CRC cis rs7412746 0.622 rs72704654 chr1:150826410 G/A cg17724175 chr1:150552817 MCL1 0.49 7.28 0.37 2.54e-12 Melanoma; CRC cis rs9916302 0.904 rs6503506 chr17:37524653 C/A cg00129232 chr17:37814104 STARD3 0.54 8.03 0.4 1.73e-14 Glomerular filtration rate (creatinine); CRC cis rs1050631 0.564 rs1785905 chr18:33713287 T/A cg25426722 chr18:33708991 SLC39A6;ELP2 0.37 5.73 0.3 2.27e-8 Esophageal squamous cell cancer (length of survival); CRC cis rs3820928 1.000 rs4675119 chr2:227774635 A/C cg11843606 chr2:227700838 RHBDD1 -0.4 -5.94 -0.31 7.37e-9 Pulmonary function; CRC cis rs6952808 0.595 rs3778982 chr7:2166233 T/C cg21782813 chr7:2030301 MAD1L1 0.55 9.55 0.47 3.1400000000000002e-19 Bipolar disorder and schizophrenia; CRC cis rs11122272 0.735 rs2244994 chr1:231537127 C/G cg06096015 chr1:231504339 EGLN1 0.41 6.11 0.32 2.88e-9 Hemoglobin concentration; CRC cis rs9894429 1.000 rs3935543 chr17:79579874 T/C cg18240062 chr17:79603768 NPLOC4 0.56 9.34 0.46 1.54e-18 Eye color traits; CRC cis rs2257205 0.667 rs9889494 chr17:56629764 T/C cg25885038 chr17:56607967 SEPT4 -0.56 -6.21 -0.32 1.55e-9 Pancreatic cancer; CRC trans rs747782 0.528 rs10838881 chr11:48387275 T/C cg15704280 chr7:45808275 SEPT13 0.64 6.21 0.32 1.62e-9 Intraocular pressure; CRC cis rs2075671 0.903 rs11979818 chr7:100293639 A/G cg16850897 chr7:100343110 ZAN 0.62 9.01 0.44 1.72e-17 Other erythrocyte phenotypes; CRC cis rs6121246 0.567 rs6058187 chr20:30190923 T/C cg18721089 chr20:30220636 NA -0.52 -7.93 -0.4 3.54e-14 Mean corpuscular hemoglobin; CRC cis rs10883723 0.810 rs7069356 chr10:104254359 G/C cg22532475 chr10:104410764 TRIM8 -0.37 -6.86 -0.35 3.51e-11 Allergic disease (asthma, hay fever or eczema); CRC cis rs2979489 0.945 rs11992441 chr8:30313649 A/G cg26383811 chr8:30366931 RBPMS 0.72 10.18 0.49 2.52e-21 Mean corpuscular hemoglobin;Plateletcrit;Neutrophil count;Granulocyte count;Sum basophil neutrophil counts;Mean corpuscular volume;Myeloid white cell count;Sum neutrophil eosinophil counts; CRC cis rs10463316 0.817 rs12653378 chr5:150802366 A/G cg03212797 chr5:150827313 SLC36A1 -0.47 -7.13 -0.37 6.56e-12 Metabolite levels (Pyroglutamine); CRC cis rs12024301 0.557 rs79753938 chr1:183623422 A/G cg11505048 chr1:183622726 RGL1;APOBEC4 0.81 7.0 0.36 1.42e-11 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs9660180 0.875 rs4648727 chr1:1776269 C/A cg13866156 chr1:1669148 SLC35E2 0.52 7.89 0.4 4.42e-14 Body mass index; CRC trans rs6472827 0.645 rs16836 chr8:75114062 T/C cg16732884 chr16:2569654 AMDHD2;ATP6V0C 0.38 5.97 0.31 6.16e-9 Uterine fibroids; CRC trans rs4650994 0.525 rs4316329 chr1:178509333 C/T cg05059571 chr16:84539110 KIAA1609 -0.59 -8.21 -0.41 5e-15 HDL cholesterol levels;HDL cholesterol; CRC cis rs35306767 0.855 rs55697724 chr10:885622 T/C cg20503657 chr10:835505 NA 1.26 14.89 0.63 1.11e-38 Eosinophil percentage of granulocytes; CRC trans rs6951245 0.507 rs11976805 chr7:1138716 C/T cg13565492 chr6:43139072 SRF -0.75 -10.01 -0.48 9.26e-21 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs13108904 0.901 rs6851528 chr4:1296009 G/A cg19318889 chr4:1322082 MAEA 0.43 6.47 0.34 3.54e-10 Obesity-related traits; CRC cis rs427941 0.632 rs201470 chr7:101744045 G/A cg06246474 chr7:101738831 CUX1 0.43 6.68 0.35 1.01e-10 Plasma omega-3 polyunsaturated fatty acid level (eicosapentaenoic acid); CRC cis rs11190604 1.000 rs11190613 chr10:102313997 C/T cg16342193 chr10:102329863 NA 0.35 5.79 0.3 1.62e-8 Palmitoleic acid (16:1n-7) levels; CRC cis rs1707322 0.686 rs1547924 chr1:46085112 C/T cg06784218 chr1:46089804 CCDC17 0.66 12.24 0.56 1.25e-28 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs8060686 0.641 rs113896227 chr16:68101480 C/T cg08314208 chr16:67682810 RLTPR -0.65 -6.89 -0.36 2.84e-11 HDL cholesterol;Metabolic syndrome; CRC cis rs1801251 0.574 rs2250660 chr2:233752551 G/C cg25237894 chr2:233734115 C2orf82 -0.5 -7.85 -0.4 5.78e-14 Coronary artery disease; CRC cis rs208520 0.690 rs10455595 chr6:66738034 T/C cg07460842 chr6:66804631 NA 1.06 14.78 0.63 2.91e-38 Exhaled nitric oxide output; CRC cis rs3026101 0.671 rs3026128 chr17:5293962 T/C cg25236894 chr17:5323110 RPAIN;NUP88 0.42 6.84 0.35 3.98e-11 Body mass index; CRC cis rs9372498 0.572 rs10484289 chr6:118827836 T/C cg01339444 chr6:118972232 C6orf204 0.53 6.06 0.32 3.81e-9 Diastolic blood pressure; CRC cis rs10504229 1.000 rs66840104 chr8:58190001 C/T cg02725872 chr8:58115012 NA -0.38 -6.43 -0.33 4.44e-10 Developmental language disorder (linguistic errors); CRC cis rs6502050 0.835 rs4789751 chr17:80092373 G/T cg11859384 chr17:80120422 CCDC57 -0.38 -6.03 -0.32 4.47e-9 Life satisfaction; CRC cis rs3820068 0.603 rs7531396 chr1:15969870 G/C cg27534772 chr1:16042836 PLEKHM2 0.54 10.12 0.49 3.78e-21 Systolic blood pressure; CRC cis rs11627756 0.958 rs10131189 chr14:103091440 C/G cg12046867 chr14:103022105 NA -0.44 -5.82 -0.31 1.37e-8 Mean platelet volume; CRC cis rs7666738 0.830 rs11932942 chr4:98998939 T/C cg17366294 chr4:99064904 C4orf37 0.44 7.39 0.38 1.19e-12 Colonoscopy-negative controls vs population controls; CRC cis rs11997175 0.624 rs7016783 chr8:33696831 A/G ch.8.33884649F chr8:33765107 NA 0.46 6.7 0.35 9.1e-11 Body mass index; CRC cis rs1109861 0.525 rs606139 chr10:11205719 A/G cg08389350 chr10:11198709 CUGBP2 -0.35 -5.63 -0.3 3.92e-8 Urinary albumin-to-creatinine ratio; CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg12290896 chr5:96038388 CAST -0.52 -6.83 -0.35 4.14e-11 Diisocyanate-induced asthma; CRC cis rs2243480 0.901 rs57126451 chr7:65416306 T/C cg12463550 chr7:65579703 CRCP 0.63 5.98 0.31 5.8e-9 Diabetic kidney disease; CRC trans rs7267979 0.833 rs6138556 chr20:25243310 C/T cg17903999 chr18:56338584 MALT1 -0.41 -6.48 -0.34 3.3e-10 Liver enzyme levels (alkaline phosphatase); CRC cis rs4713118 0.615 rs9295747 chr6:27736993 G/T cg21251018 chr6:28226885 NKAPL -0.38 -5.87 -0.31 1.09e-8 Parkinson's disease; CRC cis rs7647973 0.580 rs4955432 chr3:49266772 C/T cg07636037 chr3:49044803 WDR6 0.84 12.66 0.57 3.49e-30 Menarche (age at onset); CRC cis rs6502050 0.835 rs55679819 chr17:80105450 C/T cg13198984 chr17:80129470 CCDC57 0.47 8.26 0.41 3.61e-15 Life satisfaction; CRC cis rs907683 0.570 rs2666104 chr2:220281010 C/T cg15015639 chr2:220282977 DES -0.41 -6.71 -0.35 8.54e-11 Resting heart rate; CRC trans rs10802346 0.545 rs10802347 chr1:246374268 G/A cg22732515 chr19:44031385 ETHE1 0.69 10.41 0.5 4.04e-22 Fractional exhaled nitric oxide (childhood); CRC cis rs1215050 0.765 rs1530905 chr4:98805705 A/G cg05340658 chr4:99064831 C4orf37 0.47 6.96 0.36 1.84e-11 Waist-to-hip ratio adjusted for body mass index; CRC cis rs2404602 0.735 rs12906143 chr15:76709523 T/A cg03037974 chr15:76606532 NA -0.52 -7.35 -0.38 1.54e-12 Blood metabolite levels; CRC cis rs933688 0.536 rs332537 chr5:90794973 C/T cg02339078 chr5:90679543 LOC100129716;ARRDC3 -0.64 -8.13 -0.41 8.65e-15 Smoking behavior; CRC cis rs6502050 0.799 rs7212023 chr17:80170354 G/A cg22110888 chr17:80059540 CCDC57 0.42 6.67 0.35 1.1e-10 Life satisfaction; CRC cis rs7703744 0.634 rs6884061 chr5:118683431 C/T cg23917399 chr5:118691751 TNFAIP8 0.43 6.15 0.32 2.27e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs422249 0.512 rs174546 chr11:61569830 C/T cg06781209 chr11:61594997 FADS2 -0.38 -5.74 -0.3 2.11e-8 Trans fatty acid levels; CRC cis rs1862618 0.853 rs252904 chr5:56118733 A/T cg20203395 chr5:56204925 C5orf35 -0.66 -8.19 -0.41 5.69e-15 Initial pursuit acceleration; CRC cis rs736408 0.736 rs4687550 chr3:52823430 T/G cg18404041 chr3:52824283 ITIH1 -0.54 -11.19 -0.53 7.49e-25 Bipolar disorder; CRC cis rs2075371 1.000 rs2598288 chr7:133977304 A/T cg20476274 chr7:133979776 SLC35B4 0.81 14.98 0.64 4.66e-39 Mean platelet volume; CRC cis rs73200209 0.744 rs73200239 chr12:116684424 G/C cg01776926 chr12:116560359 MED13L -0.61 -7.27 -0.37 2.66e-12 Total body bone mineral density; CRC cis rs3008870 0.629 rs12742428 chr1:67426487 A/G cg08660285 chr1:67390436 MIER1;WDR78 0.54 7.63 0.39 2.59e-13 Lymphocyte percentage of white cells; CRC cis rs769267 0.930 rs4808965 chr19:19631655 A/G cg01262667 chr19:19385393 TM6SF2 0.36 5.88 0.31 1.01e-8 Tonsillectomy; CRC trans rs3733585 0.673 rs6836706 chr4:9964251 T/A cg26043149 chr18:55253948 FECH -0.5 -7.62 -0.39 2.81e-13 Cleft plate (environmental tobacco smoke interaction); CRC cis rs12477438 0.798 rs6704766 chr2:99642818 T/C cg14399236 chr2:99771627 LIPT1;TSGA10 -0.74 -10.4 -0.5 4.36e-22 Chronic sinus infection; CRC cis rs7618915 0.621 rs6788993 chr3:52605136 T/C cg15147215 chr3:52552868 STAB1 -0.66 -11.34 -0.53 2.19e-25 Bipolar disorder; CRC cis rs7224685 0.501 rs781852 chr17:3953102 A/G cg05562828 chr17:3906858 NA 0.67 12.33 0.56 5.66e-29 Type 2 diabetes; CRC cis rs2228479 0.850 rs62054640 chr16:89823157 C/T cg19635926 chr16:89946313 TCF25 0.63 5.68 0.3 3.01e-8 Skin colour saturation; CRC cis rs11758351 1.000 rs112751982 chr6:26191958 C/T cg01420254 chr6:26195488 NA 0.83 8.68 0.43 1.82e-16 Gout;Renal underexcretion gout; CRC trans rs1005277 0.541 rs2263163 chr10:38389887 G/A cg23533926 chr12:111358616 MYL2 -0.52 -7.81 -0.4 7.93e-14 Extrinsic epigenetic age acceleration; CRC cis rs1552244 0.882 rs13062917 chr3:10017032 T/A cg00166722 chr3:10149974 C3orf24 0.61 7.92 0.4 3.81e-14 Alzheimer's disease; CRC cis rs853679 0.517 rs12174753 chr6:28042465 C/G cg15845792 chr6:28175446 NA 0.97 13.0 0.58 1.75e-31 Depression; CRC cis rs9486719 1.000 rs12214469 chr6:97019471 G/T cg06623918 chr6:96969491 KIAA0776 -0.82 -9.53 -0.47 3.58e-19 Migraine;Coronary artery disease; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg03425468 chr1:155164676 MIR92B -0.43 -6.26 -0.33 1.17e-9 Myopia (pathological); CRC cis rs4509693 0.843 rs4403743 chr10:102496740 A/C cg23167259 chr10:102495509 NA -0.46 -6.31 -0.33 8.87e-10 Alzheimer's disease; CRC cis rs12291225 0.535 rs10832248 chr11:14413087 G/A cg05501817 chr11:14380813 RRAS2 -0.44 -6.01 -0.31 4.85e-9 Sense of smell; CRC cis rs9611565 0.659 rs12484228 chr22:41939739 A/G cg03806693 chr22:41940476 POLR3H -1.11 -14.99 -0.64 4.38e-39 Vitiligo; CRC cis rs6968419 0.747 rs1004107 chr7:115860783 A/T cg02561103 chr7:115862891 TES -0.43 -6.47 -0.34 3.58e-10 Intraocular pressure; CRC cis rs2721195 0.967 rs1480000 chr8:145702007 C/T cg15857475 chr8:145742913 RECQL4;LRRC14 -0.72 -12.19 -0.56 1.89e-28 Age at first birth; CRC cis rs1552244 1.000 rs57631744 chr3:10118962 T/C cg10729496 chr3:10149963 C3orf24 0.5 6.81 0.35 4.67e-11 Alzheimer's disease; CRC cis rs40363 0.645 rs250633 chr16:3523002 C/T cg00484396 chr16:3507460 NAT15 0.53 8.04 0.41 1.6e-14 Tuberculosis; CRC cis rs881375 0.933 rs7859805 chr9:123664123 A/G cg00246817 chr9:123691163 NA -0.47 -6.04 -0.32 4.11e-9 Rheumatoid arthritis; CRC cis rs853679 0.517 rs4713135 chr6:28039586 G/A cg15845792 chr6:28175446 NA 0.96 12.86 0.58 6.21e-31 Depression; CRC cis rs7937682 0.855 rs571462 chr11:111487106 C/G cg09085632 chr11:111637200 PPP2R1B -0.98 -19.21 -0.73 1.09e-55 Primary sclerosing cholangitis; CRC cis rs2204008 0.811 rs4882300 chr12:38415224 A/T cg26384229 chr12:38710491 ALG10B -0.64 -9.53 -0.47 3.53e-19 Bladder cancer; CRC cis rs11212617 0.935 rs227064 chr11:108207393 T/C cg01991180 chr11:108092276 ATM;NPAT 0.42 6.16 0.32 2.11e-9 Response to metformin in type 2 diabetes (glycemic); CRC cis rs6963495 0.585 rs1706923 chr7:105221097 A/G cg02135003 chr7:105160482 PUS7 -0.53 -8.35 -0.42 1.93e-15 Bipolar disorder (body mass index interaction); CRC cis rs11958404 0.932 rs72816581 chr5:157432591 T/A cg05962755 chr5:157440814 NA 1.01 12.88 0.58 5.12e-31 IgG glycosylation; CRC cis rs1153858 1.000 rs28679834 chr15:45616206 C/T cg10760299 chr15:45669010 GATM 0.53 8.28 0.42 3.15e-15 Homoarginine levels; CRC cis rs511515 1 rs511515 chr6:33541507 A/G cg24505687 chr6:33548425 BAK1 0.36 6.17 0.32 2.01e-9 Eosinophil counts;Sum eosinophil basophil counts;Eosinophil percentage of white cells; CRC cis rs7246760 1.000 rs17849496 chr19:9922223 G/A cg16876255 chr19:9731953 ZNF561 0.69 5.68 0.3 2.92e-8 Pursuit maintenance gain; CRC cis rs13108904 0.535 rs1250101 chr4:1236111 G/A cg15763984 chr4:1342303 KIAA1530 -0.38 -5.8 -0.3 1.59e-8 Obesity-related traits; CRC cis rs7224685 0.501 rs8066272 chr17:3900528 C/T cg09597638 chr17:3907349 NA 0.71 13.19 0.59 3.41e-32 Type 2 diabetes; CRC cis rs28386778 0.897 rs1982400 chr17:61793818 T/C cg06601766 chr17:61851465 DDX42;CCDC47 0.42 5.64 0.3 3.68e-8 Prudent dietary pattern; CRC cis rs6547741 0.874 rs28381983 chr2:27804432 T/C cg27432699 chr2:27873401 GPN1 0.74 12.56 0.57 7.64e-30 Oral cavity cancer; CRC cis rs6121246 0.559 rs6121172 chr20:30296095 A/C cg13852791 chr20:30311386 BCL2L1 0.76 14.77 0.63 3.17e-38 Mean corpuscular hemoglobin; CRC trans rs6550704 0.687 rs9865314 chr3:22634337 A/G cg06052471 chr11:61130074 TMEM138;CYBASC3 -0.42 -6.11 -0.32 2.75e-9 Daytime sleep phenotypes; CRC cis rs919433 0.817 rs10931780 chr2:198175297 G/C cg03934865 chr2:198174659 NA -0.47 -8.57 -0.43 4.2e-16 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC cis rs4862750 0.872 rs10027252 chr4:187873462 T/G cg11301795 chr4:187892539 NA -0.84 -17.52 -0.69 5.23e-49 Lobe attachment (rater-scored or self-reported); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg23396286 chr10:99258505 UBTD1;MMS19 0.44 6.27 0.33 1.12e-9 Response to antipsychotic treatment; CRC cis rs11608355 1.000 rs10850135 chr12:109866528 C/A cg19025524 chr12:109796872 NA -0.47 -6.68 -0.35 1.01e-10 Neuroticism; CRC trans rs17270561 0.636 rs1165157 chr6:25792250 A/G cg02936872 chr9:99801550 CTSL2 0.48 6.18 0.32 1.85e-9 Iron status biomarkers; CRC cis rs7772486 0.790 rs3923579 chr6:146230232 C/G cg13319975 chr6:146136371 FBXO30 0.43 6.51 0.34 2.87e-10 Lobe attachment (rater-scored or self-reported); CRC cis rs8060686 0.698 rs8044558 chr16:68210165 T/C cg26727032 chr16:67993705 SLC12A4 -0.57 -7.56 -0.38 4.01e-13 HDL cholesterol;Metabolic syndrome; CRC cis rs55871839 0.559 rs4737527 chr8:59823491 A/G cg07426533 chr8:59803705 TOX 0.43 6.23 0.32 1.42e-9 Pneumonia; CRC cis rs2281845 0.791 rs1325313 chr1:201076167 C/T cg01987224 chr1:201084466 NA 0.54 10.01 0.48 9.48e-21 Permanent tooth development; CRC cis rs6502050 0.835 rs28640920 chr17:80105151 A/T cg25804541 chr17:80189381 SLC16A3 -0.31 -5.97 -0.31 6.08e-9 Life satisfaction; CRC cis rs4658101 0.700 rs6677520 chr1:92052231 A/G cg24006770 chr1:92056542 NA 0.48 7.12 0.37 7e-12 Optic disc area;Vertical cup-disc ratio; CRC cis rs12230513 0.732 rs7980098 chr12:55844694 A/G cg19537932 chr12:55886519 OR6C68 -0.73 -9.52 -0.46 3.94e-19 Contrast sensitivity; CRC cis rs968567 0.559 rs174544 chr11:61567753 C/A cg00603274 chr11:61596626 FADS2 -0.49 -6.92 -0.36 2.42e-11 Blood metabolite levels;Rheumatoid arthritis;Vitiligo;Glycerophospholipid levels; CRC cis rs796364 0.664 rs4673660 chr2:200915395 C/T cg23649088 chr2:200775458 C2orf69 0.61 6.47 0.34 3.62e-10 Schizophrenia; CRC cis rs853679 0.628 rs9368560 chr6:28159960 T/C cg02631126 chr6:28058918 ZSCAN12L1 0.27 5.77 0.3 1.8e-8 Depression; CRC cis rs375066 0.623 rs62114569 chr19:44354624 T/C cg19542119 chr19:44331823 ZNF283 0.4 5.61 0.3 4.24e-8 Breast cancer; CRC cis rs2739330 0.760 rs1007888 chr22:24241101 C/T cg09033563 chr22:24373618 LOC391322 -0.42 -5.96 -0.31 6.65e-9 Liver enzyme levels (gamma-glutamyl transferase); CRC trans rs2280018 0.526 rs1510148 chr16:15167379 T/A cg04146151 chr16:2155961 PKD1 -0.48 -6.28 -0.33 1.1e-9 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid);Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CRC cis rs4867766 0.789 rs17725606 chr5:173956965 A/C cg20434911 chr5:173954559 NA -0.8 -9.11 -0.45 7.96e-18 Stroke; CRC cis rs853679 0.517 rs12174753 chr6:28042465 C/G cg21251018 chr6:28226885 NKAPL 0.47 6.17 0.32 1.95e-9 Depression; CRC cis rs4746818 1.000 rs4746817 chr10:70882515 T/C cg11621586 chr10:70884670 VPS26A 0.9 8.35 0.42 1.94e-15 Left atrial antero-posterior diameter; CRC cis rs6860806 0.661 rs6890009 chr5:131580033 G/T cg09877947 chr5:131593287 PDLIM4 0.44 8.09 0.41 1.14e-14 Breast cancer; CRC cis rs1448094 0.511 rs10863083 chr12:86226739 C/A cg02569458 chr12:86230093 RASSF9 0.44 7.52 0.38 5.28e-13 Major depressive disorder; CRC cis rs1153858 1.000 rs12593370 chr15:45617417 C/T cg14582100 chr15:45693742 SPATA5L1 0.29 5.69 0.3 2.83e-8 Homoarginine levels; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg03428813 chr2:62115351 CCT4 0.5 6.32 0.33 8.47e-10 Thyroid stimulating hormone; CRC cis rs3862030 0.503 rs10786673 chr10:104280537 G/A cg22532475 chr10:104410764 TRIM8 -0.36 -6.79 -0.35 5.16e-11 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for body mass index; CRC cis rs13108904 0.967 rs11247986 chr4:1294347 G/A cg16405210 chr4:1374714 KIAA1530 -0.44 -5.95 -0.31 7.04e-9 Obesity-related traits; CRC cis rs11190604 1.000 rs2495732 chr10:102357780 T/C cg16342193 chr10:102329863 NA -0.4 -6.3 -0.33 9.79e-10 Palmitoleic acid (16:1n-7) levels; CRC trans rs10877945 0.522 rs7297754 chr12:63443521 T/C cg03429785 chr15:59498649 MYO1E;LDHAL6B -0.4 -6.08 -0.32 3.37e-9 Obesity-related traits; CRC cis rs9368481 0.743 rs9368480 chr6:26955750 A/C cg05192639 chr6:26864778 GUSBL1 0.39 6.73 0.35 7.74e-11 Autism spectrum disorder or schizophrenia; CRC cis rs9322193 0.962 rs9688412 chr6:150124283 A/G cg13206674 chr6:150067644 NUP43 -0.58 -8.39 -0.42 1.4e-15 Lung cancer; CRC cis rs9322193 0.923 rs12660304 chr6:150060783 A/G cg13206674 chr6:150067644 NUP43 0.66 10.05 0.48 6.87e-21 Lung cancer; CRC cis rs1552244 0.572 rs59132826 chr3:10169725 G/A cg02579736 chr3:10068473 FANCD2;CIDECP 1.01 11.62 0.54 2.28e-26 Alzheimer's disease; CRC cis rs2530545 0.762 rs1833112 chr7:34665112 C/T cg14401837 chr7:34697493 NPSR1 0.39 5.75 0.3 2.01e-8 IgG glycosylation; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg13363640 chr11:2985302 SNORA54;NAP1L4 0.38 6.0 0.31 5.15e-9 Liver disease severity in Alagille syndrome; CRC cis rs733175 0.855 rs9291641 chr4:10007259 C/T cg00071950 chr4:10020882 SLC2A9 0.4 5.71 0.3 2.54e-8 Psychosis and Alzheimer's disease; CRC cis rs8031584 0.723 rs711224 chr15:31127921 G/C cg08704250 chr15:31115839 NA 0.55 9.92 0.48 1.78e-20 Huntington's disease progression; CRC cis rs4730250 0.707 rs6977868 chr7:106790555 T/G cg02696742 chr7:106810147 HBP1 0.58 6.26 0.33 1.22e-9 Osteoarthritis; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg11224423 chr12:56136943 GDF11 0.43 7.06 0.36 1.02e-11 Liver disease severity in Alagille syndrome; CRC cis rs6838801 0.752 rs6817407 chr4:77616338 C/G cg17476223 chr4:77663285 SHROOM3 -0.45 -6.06 -0.32 3.72e-9 Cleft lip with or without cleft palate; CRC cis rs9517320 0.534 rs4772090 chr13:99150674 T/C cg07423050 chr13:99094983 FARP1 -0.53 -7.59 -0.39 3.35e-13 Longevity; CRC cis rs4713118 0.824 rs9366702 chr6:27734470 T/C cg20933634 chr6:27740509 NA 0.65 9.16 0.45 5.64e-18 Parkinson's disease; CRC cis rs881375 0.715 rs10818482 chr9:123648085 C/T cg09419670 chr9:123605666 PSMD5;LOC253039 -0.46 -6.99 -0.36 1.57e-11 Rheumatoid arthritis; CRC cis rs17767392 0.958 rs2109276 chr14:71889767 G/A cg13720639 chr14:72061746 SIPA1L1 -0.55 -6.95 -0.36 1.96e-11 Mitral valve prolapse; CRC cis rs4824093 0.610 rs4141437 chr22:50243719 C/G cg22709217 chr22:50311962 ALG12;CRELD2 0.92 8.21 0.41 5.11e-15 Amyotrophic lateral sclerosis (sporadic); CRC cis rs853679 0.517 rs1904840 chr6:28108232 C/T cg21251018 chr6:28226885 NKAPL 0.48 6.17 0.32 2.02e-9 Depression; CRC trans rs2727020 0.729 rs588458 chr11:49214048 C/A cg03929089 chr4:120376271 NA 0.82 13.72 0.6 3.47e-34 Coronary artery disease; CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg13482356 chr1:118148519 FAM46C -0.5 -6.0 -0.31 5.29e-9 Diisocyanate-induced asthma; CRC trans rs2303319 0.504 rs62189053 chr2:162624324 G/A cg11326919 chr17:43324904 LOC100133991 -0.64 -5.99 -0.31 5.65e-9 Cognitive function; CRC cis rs6951245 1.000 rs74347384 chr7:1072440 G/A cg03188948 chr7:1209495 NA 0.63 6.52 0.34 2.64e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs7208859 0.623 rs58089675 chr17:29196764 C/G cg01831904 chr17:28903510 LRRC37B2 -0.55 -5.77 -0.3 1.88e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs853679 0.542 rs9380063 chr6:28137853 A/G cg12172441 chr6:28176163 NA 0.64 7.53 0.38 5.03e-13 Depression; CRC trans rs1945213 0.694 rs7106894 chr11:55877315 T/C cg03929089 chr4:120376271 NA 0.55 6.34 0.33 7.61e-10 Acute lymphoblastic leukemia (childhood); CRC cis rs924607 0.966 rs1709554 chr5:637443 A/G cg04221910 chr5:616842 CEP72 0.41 6.77 0.35 5.99e-11 Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia; CRC cis rs7586879 1.000 rs10207698 chr2:25117672 C/T cg22495460 chr2:25135724 ADCY3 -0.73 -11.97 -0.55 1.19e-27 Body mass index; CRC cis rs798554 0.757 rs2533879 chr7:2859847 G/A cg13628971 chr7:2884303 GNA12 0.53 7.13 0.37 6.45e-12 Height; CRC cis rs6674176 0.593 rs3791120 chr1:44431715 T/C cg12908607 chr1:44402522 ARTN -0.54 -9.67 -0.47 1.21e-19 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Cognitive ability; CRC cis rs7829975 0.806 rs2428 chr8:8641145 C/T cg08975724 chr8:8085496 FLJ10661 0.43 6.92 0.36 2.38e-11 Mood instability; CRC cis rs9937943 0.667 rs9945 chr16:74490556 G/A cg01733217 chr16:74700730 RFWD3 0.65 6.8 0.35 4.91e-11 Neutrophil percentage of white cells; CRC cis rs12711979 0.765 rs7559345 chr2:3818523 G/A cg17052675 chr2:3827356 NA -0.55 -10.42 -0.5 3.73e-22 Itch intensity from mosquito bite adjusted by bite size; CRC cis rs2811415 0.597 rs10934844 chr3:127749651 T/C cg13719885 chr3:127795394 NA -0.39 -5.99 -0.31 5.56e-9 Lung function (FEV1/FVC); CRC cis rs7412746 0.634 rs12096831 chr1:150864113 T/G cg18016565 chr1:150552671 MCL1 0.41 5.78 0.3 1.72e-8 Melanoma; CRC cis rs365302 1.000 rs419281 chr6:159642860 G/A cg14500486 chr6:159655392 FNDC1 0.45 6.86 0.35 3.39e-11 Coronary heart disease; CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg25764190 chr19:44037015 ZNF575 -0.52 -6.36 -0.33 6.83e-10 Diisocyanate-induced asthma; CRC trans rs3733585 0.673 rs7378340 chr4:9955198 C/T cg26043149 chr18:55253948 FECH -0.48 -7.35 -0.38 1.56e-12 Cleft plate (environmental tobacco smoke interaction); CRC cis rs2307022 0.586 rs2279539 chr16:68395094 G/A cg02226672 chr16:68398533 SMPD3 0.29 5.72 0.3 2.4e-8 Body mass index; CRC cis rs4862750 0.872 rs6553030 chr4:187899234 T/C cg03452623 chr4:187889614 NA -0.92 -22.45 -0.78 2.37e-68 Lobe attachment (rater-scored or self-reported); CRC cis rs2836974 0.897 rs1541102 chr21:40628765 C/T cg06238570 chr21:40685208 BRWD1 0.74 10.5 0.5 1.91e-22 Cognitive function; CRC cis rs478304 0.934 rs506853 chr11:65521247 C/T cg27068330 chr11:65405492 SIPA1 0.44 6.55 0.34 2.26e-10 Acne (severe); CRC trans rs2303319 0.504 rs62189041 chr2:162599506 T/C cg13490827 chr1:46269305 MAST2 -0.69 -6.0 -0.31 5.24e-9 Cognitive function; CRC cis rs6951245 0.554 rs2070118 chr7:1132505 G/A cg18402987 chr7:1209562 NA 0.55 6.66 0.34 1.12e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs6840360 0.593 rs1366907 chr4:152682749 T/C cg09659197 chr4:152720779 NA 0.42 8.71 0.43 1.47e-16 Intelligence (multi-trait analysis); CRC trans rs4263408 0.934 rs9683743 chr4:39703194 A/C cg17276082 chr9:140083193 ANAPC2;SSNA1 -0.44 -6.45 -0.34 3.94e-10 Plasma amyloid beta peptide concentrations (ABx-40); CRC cis rs4713118 0.629 rs203887 chr6:28021269 C/T cg21251018 chr6:28226885 NKAPL 0.47 6.3 0.33 9.69e-10 Parkinson's disease; CRC cis rs12541635 0.966 rs10955409 chr8:107022586 A/C cg10147462 chr8:107024639 NA 0.43 7.34 0.38 1.69e-12 Age of smoking initiation; CRC cis rs9611519 0.929 rs12484477 chr22:41429084 G/A cg03806693 chr22:41940476 POLR3H -0.53 -6.8 -0.35 4.83e-11 Neuroticism; CRC cis rs832540 0.801 rs7731700 chr5:56111927 C/T cg18230493 chr5:56204884 C5orf35 -0.4 -5.79 -0.3 1.68e-8 Coronary artery disease; CRC cis rs13108904 0.870 rs13124876 chr4:1247955 T/C cg21620606 chr4:1342894 KIAA1530 0.4 6.96 0.36 1.84e-11 Obesity-related traits; CRC cis rs1153858 1.000 rs7171577 chr15:45627979 G/A cg10760299 chr15:45669010 GATM 0.49 7.71 0.39 1.54e-13 Homoarginine levels; CRC cis rs9948 0.655 rs62152771 chr2:97447121 C/G cg20312557 chr2:97357134 FER1L5 -0.61 -5.62 -0.3 4.18e-8 Erectile dysfunction and prostate cancer treatment; CRC cis rs9649213 0.593 rs6967457 chr7:97912221 T/G cg00277769 chr7:97922759 BAIAP2L1 -0.61 -10.71 -0.51 3.59e-23 Prostate cancer (SNP x SNP interaction); CRC cis rs6534441 0.727 rs6844455 chr4:125429497 G/A cg21609808 chr4:125404261 NA 0.42 5.94 0.31 7.18e-9 Major depressive disorder; CRC cis rs561341 0.739 rs7213369 chr17:30211878 G/A cg13647721 chr17:30228624 UTP6 -0.63 -7.51 -0.38 5.43e-13 Hip circumference adjusted for BMI; CRC trans rs1455244 0.700 rs7229302 chr18:11508904 G/T cg14067770 chr11:615950 IRF7 0.4 6.11 0.32 2.83e-9 Schizophrenia; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg18719723 chr12:48395490 COL2A1 0.4 5.99 0.31 5.63e-9 Response to antipsychotic treatment; CRC trans rs12663356 0.528 rs9350359 chr6:21462624 C/T cg24023498 chr2:157199345 NA 0.39 6.0 0.31 5.07e-9 Crohn's disease; CRC cis rs9611565 0.694 rs5758368 chr22:41862288 C/T cg06481639 chr22:41940642 POLR3H -0.52 -6.29 -0.33 9.94e-10 Vitiligo; CRC cis rs12024301 0.557 rs16861394 chr1:183617693 G/A cg11505048 chr1:183622726 RGL1;APOBEC4 0.81 7.0 0.36 1.42e-11 Peripheral arterial disease (traffic-related air pollution interaction); CRC trans rs4308415 0.781 rs1481265 chr4:67813982 A/G cg19648955 chr2:177134095 MTX2 -0.42 -6.27 -0.33 1.16e-9 Educational attainment (years of education); CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg00873521 chr9:95056130 IARS;SNORA84 0.47 6.08 0.32 3.29e-9 Thyroid stimulating hormone; CRC cis rs8141529 0.636 rs5762813 chr22:29203314 C/T cg02153584 chr22:29168773 CCDC117 0.48 6.3 0.33 9.64e-10 Lymphocyte counts; CRC cis rs6951245 0.744 rs1133122 chr7:1192572 C/A cg18402987 chr7:1209562 NA 0.73 8.44 0.42 1.03e-15 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs2535633 0.602 rs6801235 chr3:53009595 T/C cg15147215 chr3:52552868 STAB1 -0.4 -6.41 -0.33 5.02e-10 Body mass index; CRC cis rs7618915 0.571 rs34954168 chr3:52612159 C/T cg08222913 chr3:52553049 STAB1 -0.34 -6.3 -0.33 9.34e-10 Bipolar disorder; CRC cis rs6752107 0.901 rs11687982 chr2:234149039 C/T cg07618928 chr2:234183455 ATG16L1;SCARNA5 0.55 8.8 0.44 7.83e-17 Crohn's disease;Inflammatory bowel disease; CRC cis rs10540 1.000 rs79440439 chr11:478147 A/C cg15790184 chr11:494944 RNH1 0.61 5.79 0.3 1.66e-8 Body mass index; CRC cis rs72717009 0.778 rs9427400 chr1:161477204 C/T cg15358701 chr1:161410459 NA -0.62 -6.63 -0.34 1.39e-10 Rheumatoid arthritis; CRC cis rs4660306 1.000 rs10157597 chr1:45990278 C/A cg03123370 chr1:45965343 CCDC163P;MMACHC -0.55 -7.81 -0.4 7.94e-14 Homocysteine levels; CRC trans rs2243480 0.901 rs73148097 chr7:65431787 A/C cg10756647 chr7:56101905 PSPH 0.72 7.69 0.39 1.71e-13 Diabetic kidney disease; CRC trans rs492478 0.892 rs75220787 chr5:3941016 C/T cg09199442 chr11:28132951 METT5D1 -0.71 -6.34 -0.33 7.54e-10 Cognitive performance; CRC cis rs3768617 0.510 rs7542640 chr1:183063738 G/A ch.1.3577855R chr1:183094577 LAMC1 0.86 15.19 0.64 7.31e-40 Fuchs's corneal dystrophy; CRC cis rs35110281 0.667 rs4819291 chr21:45123139 G/A cg04455712 chr21:45112962 RRP1B 0.4 7.54 0.38 4.51e-13 Mean corpuscular volume; CRC cis rs4499344 0.633 rs259229 chr19:33134425 A/G cg08127369 chr19:33164662 ANKRD27 -0.37 -5.65 -0.3 3.46e-8 Mean platelet volume; CRC cis rs9910055 0.529 rs228767 chr17:42188311 C/G cg13607699 chr17:42295918 UBTF -0.47 -6.07 -0.32 3.47e-9 Total body bone mineral density; CRC cis rs2032447 0.736 rs115810 chr6:25975883 G/C cg03517284 chr6:25882590 NA -0.57 -7.79 -0.39 8.79e-14 Intelligence (multi-trait analysis); CRC trans rs8002861 0.967 rs7983109 chr13:44484351 C/A cg17145862 chr1:211918768 LPGAT1 0.77 15.89 0.66 1.3e-42 Leprosy; CRC cis rs10540 0.686 rs12421266 chr11:537120 C/T cg08200582 chr11:442649 ANO9 -0.69 -7.04 -0.36 1.16e-11 Body mass index; CRC cis rs6701037 0.782 rs12760073 chr1:175139295 G/T cg14847009 chr1:175162515 KIAA0040 -0.27 -5.9 -0.31 8.91e-9 Alcohol dependence; CRC cis rs7647973 0.925 rs9881860 chr3:49352522 A/T cg07636037 chr3:49044803 WDR6 0.59 6.93 0.36 2.25e-11 Menarche (age at onset); CRC cis rs6460942 1.000 rs7791634 chr7:12401482 A/T cg20607287 chr7:12443886 VWDE -0.67 -6.78 -0.35 5.55e-11 Coronary artery disease; CRC cis rs1707322 0.827 rs10890347 chr1:46242332 A/T cg03146154 chr1:46216737 IPP -0.6 -7.78 -0.39 9.24e-14 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs77633900 0.614 rs2454453 chr15:76913976 T/A cg21673338 chr15:77095150 SCAPER -0.7 -7.02 -0.36 1.24e-11 Non-glioblastoma glioma;Glioma; CRC cis rs6540556 0.637 rs12060922 chr1:209904433 G/A cg05527609 chr1:210001259 C1orf107 -0.56 -6.21 -0.32 1.6e-9 Red blood cell count; CRC trans rs7615952 0.733 rs13314847 chr3:125644788 C/T cg07211511 chr3:129823064 LOC729375 -1.07 -17.84 -0.7 2.94e-50 Blood pressure (smoking interaction); CRC cis rs9911578 1.000 rs368186 chr17:56736659 A/G cg05425664 chr17:57184151 TRIM37 -0.5 -7.96 -0.4 2.78e-14 Intelligence (multi-trait analysis); CRC cis rs965469 1.000 rs6051810 chr20:3355384 A/G cg25506879 chr20:3388711 C20orf194 -0.4 -5.83 -0.31 1.34e-8 IFN-related cytopenia; CRC cis rs11645898 0.872 rs4788459 chr16:72153125 C/G cg14768367 chr16:72042858 DHODH -0.58 -6.53 -0.34 2.44e-10 Blood protein levels; CRC cis rs2415984 0.622 rs1761029 chr14:46934764 T/C cg14871534 chr14:47121158 RPL10L 0.4 5.76 0.3 1.98e-8 Number of children ever born; CRC cis rs17376456 0.825 rs17314825 chr5:93234937 A/G cg21475434 chr5:93447410 FAM172A 0.74 7.77 0.39 9.87e-14 Diabetic retinopathy; CRC cis rs4666002 0.510 rs74446114 chr2:28066122 T/C cg27432699 chr2:27873401 GPN1 0.54 6.16 0.32 2.16e-9 Phospholipid levels (plasma); CRC cis rs4654899 0.865 rs61779075 chr1:21417027 T/C cg02927042 chr1:21476669 EIF4G3 -0.51 -7.72 -0.39 1.45e-13 Superior frontal gyrus grey matter volume; CRC cis rs10256972 0.567 rs2960835 chr7:1202963 A/G cg04025307 chr7:1156635 C7orf50 0.67 10.71 0.51 3.54e-23 Longevity;Endometriosis; CRC cis rs2228479 0.717 rs2074904 chr16:89811546 A/G cg19635926 chr16:89946313 TCF25 0.66 5.97 0.31 6.1e-9 Skin colour saturation; CRC cis rs4713118 0.539 rs200967 chr6:27862127 A/G cg12273811 chr6:28175739 NA 0.55 7.76 0.39 1.08e-13 Parkinson's disease; CRC cis rs7107174 1.000 rs11601196 chr11:78043431 A/C cg02023728 chr11:77925099 USP35 0.49 7.4 0.38 1.15e-12 Testicular germ cell tumor; CRC cis rs7772486 0.701 rs7772717 chr6:145954854 T/C cg13319975 chr6:146136371 FBXO30 -0.46 -6.77 -0.35 5.97e-11 Lobe attachment (rater-scored or self-reported); CRC cis rs1799949 1.000 rs2037075 chr17:41305826 G/T cg19454999 chr17:41278357 BRCA1;NBR2 0.53 8.23 0.41 4.29e-15 Menopause (age at onset); CRC trans rs61931739 0.500 rs3934517 chr12:34451396 T/C cg13010199 chr12:38710504 ALG10B 0.46 6.52 0.34 2.6200000000000003e-10 Morning vs. evening chronotype; CRC cis rs666930 0.519 rs662602 chr1:120266903 C/G cg19096424 chr1:120255104 PHGDH 0.55 7.3 0.37 2.16e-12 Breast cancer; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg07483432 chr12:72079704 TMEM19 0.55 7.83 0.4 6.76e-14 Response to antipsychotic treatment; CRC trans rs1814175 0.817 rs11518158 chr11:49985633 G/T cg15704280 chr7:45808275 SEPT13 -0.97 -18.82 -0.72 3.98e-54 Height; CRC cis rs35110281 0.622 rs9977258 chr21:44976485 G/T cg04455712 chr21:45112962 RRP1B 0.41 7.87 0.4 5.22e-14 Mean corpuscular volume; CRC cis rs514406 0.607 rs1930305 chr1:53195481 G/T cg24675658 chr1:53192096 ZYG11B 0.69 10.61 0.5 8.49e-23 Monocyte count; CRC cis rs6674176 0.628 rs3791116 chr1:44414156 T/A cg15962314 chr1:44399869 ARTN 0.29 5.68 0.3 2.91e-8 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Cognitive ability; CRC cis rs1218582 0.772 rs4845682 chr1:154877105 T/C cg06221963 chr1:154839813 KCNN3 -0.76 -15.38 -0.65 1.34e-40 Prostate cancer; CRC cis rs2949837 0.581 rs1117457 chr7:45970037 G/A cg04796162 chr7:45961102 IGFBP3 0.38 6.62 0.34 1.49e-10 Sitting height ratio; CRC cis rs2404602 1.000 rs2404741 chr15:76851735 C/T cg23625390 chr15:77176239 SCAPER 0.65 10.31 0.49 8.72e-22 Blood metabolite levels; CRC cis rs1552244 0.572 rs67227131 chr3:10172744 G/A cg00166722 chr3:10149974 C3orf24 0.71 7.47 0.38 7.07e-13 Alzheimer's disease; CRC cis rs1003719 0.688 rs2000416 chr21:38540089 T/A cg10648535 chr21:38446584 PIGP;TTC3 -0.48 -6.55 -0.34 2.25e-10 Eye color traits; CRC cis rs2836974 0.568 rs11910906 chr21:40685662 T/C cg22974920 chr21:40686053 BRWD1 -0.44 -6.02 -0.32 4.58e-9 Cognitive function; CRC cis rs6964587 1.000 rs7802668 chr7:91648939 A/G cg17063962 chr7:91808500 NA 0.8 14.27 0.62 2.79e-36 Breast cancer; CRC trans rs11098499 0.754 rs28643450 chr4:120245242 G/A cg25214090 chr10:38739885 LOC399744 0.53 8.36 0.42 1.78e-15 Corneal astigmatism; CRC trans rs8002861 0.935 rs1373903 chr13:44475514 G/T cg17145862 chr1:211918768 LPGAT1 0.76 15.42 0.65 9.52e-41 Leprosy; CRC cis rs12142240 0.698 rs79490411 chr1:46813568 G/A cg00530320 chr1:46809349 NSUN4 0.55 6.85 0.35 3.59e-11 Menopause (age at onset); CRC cis rs2274273 0.553 rs56166765 chr14:55738018 T/C cg10130446 chr14:55658398 DLGAP5 -0.43 -6.17 -0.32 2.04e-9 Protein biomarker; CRC cis rs7615952 0.866 rs11922276 chr3:125631326 G/T cg05084668 chr3:125655381 ALG1L -0.57 -8.12 -0.41 9.14e-15 Blood pressure (smoking interaction); CRC cis rs13161895 1.000 rs1102191 chr5:179416210 C/T cg02702477 chr5:179499311 RNF130 0.55 6.38 0.33 6.16e-10 LDL cholesterol; CRC cis rs11098499 0.955 rs1511019 chr4:120166007 T/G cg24375607 chr4:120327624 NA 0.47 7.34 0.38 1.7e-12 Corneal astigmatism; CRC cis rs9325144 0.513 rs12313652 chr12:38665412 G/A cg26384229 chr12:38710491 ALG10B -0.55 -8.14 -0.41 8.04e-15 Morning vs. evening chronotype; CRC cis rs736408 0.716 rs2239550 chr3:52822509 G/C cg15147215 chr3:52552868 STAB1 -0.59 -9.28 -0.46 2.29e-18 Bipolar disorder; CRC cis rs72945132 0.882 rs7114200 chr11:70186099 C/A cg14191688 chr11:70257035 CTTN 0.43 5.74 0.3 2.12e-8 Coronary artery disease; CRC cis rs7552404 0.628 rs4949686 chr1:76473299 G/C cg22875332 chr1:76189707 ACADM 0.57 6.62 0.34 1.47e-10 Blood metabolite levels;Acylcarnitine levels; CRC cis rs4474465 0.850 rs7122676 chr11:78268525 A/G cg02023728 chr11:77925099 USP35 -0.38 -6.35 -0.33 7.09e-10 Alzheimer's disease (survival time); CRC trans rs9929218 0.551 rs9888942 chr16:68727572 A/G cg04657470 chr2:198365150 HSPE1;HSPD1 1.11 25.2 0.81 8.66e-79 Colorectal cancer; CRC cis rs6089584 0.889 rs6142923 chr20:60596617 C/T cg13770153 chr20:60521292 NA 0.67 9.67 0.47 1.2e-19 Body mass index; CRC cis rs8180040 1.000 rs295428 chr3:47359262 G/T cg27129171 chr3:47204927 SETD2 0.55 8.67 0.43 2.03e-16 Colorectal cancer; CRC cis rs1401999 1.000 rs6800217 chr3:183685893 T/C cg05044414 chr3:183734942 ABCC5 0.47 8.11 0.41 1.03e-14 Anterior chamber depth; CRC cis rs7771547 0.573 rs544267 chr6:36398302 A/G cg04289385 chr6:36355825 ETV7 0.38 5.61 0.3 4.25e-8 Platelet distribution width; CRC cis rs722599 0.748 rs2537824 chr14:75367349 T/C cg08847533 chr14:75593920 NEK9 -0.43 -5.88 -0.31 1.02e-8 IgG glycosylation; CRC cis rs17253792 0.822 rs74653073 chr14:56079528 T/C cg24579896 chr14:56047964 C14orf33;KTN1 0.71 5.69 0.3 2.81e-8 Putamen volume; CRC cis rs6988985 0.765 rs28753687 chr8:143988377 T/C cg10324643 chr8:143916377 GML 0.37 5.89 0.31 9.65e-9 Plasma androstenedione levels in resected early stage-receptor positive breast cancer; CRC cis rs1395 0.767 rs1821986 chr2:27405835 A/G cg23587288 chr2:27483067 SLC30A3 0.34 6.01 0.31 4.82e-9 Blood metabolite levels; CRC cis rs7615952 0.599 rs6438955 chr3:125730333 C/A cg04553112 chr3:125709451 NA -0.5 -6.19 -0.32 1.82e-9 Blood pressure (smoking interaction); CRC cis rs6502050 0.835 rs8078087 chr17:80113322 T/G cg02741985 chr17:80059408 CCDC57 0.43 7.15 0.37 5.66e-12 Life satisfaction; CRC cis rs12926788 0.640 rs73551577 chr16:24845143 G/A cg06028605 chr16:24865363 SLC5A11 0.6 9.96 0.48 1.31e-20 Ejection fraction in Tripanosoma cruzi seropositivity; CRC cis rs11098499 0.954 rs10031483 chr4:120422636 T/C cg09307838 chr4:120376055 NA 0.71 10.96 0.52 5.0600000000000004e-24 Corneal astigmatism; CRC trans rs561341 1.000 rs510264 chr17:30323414 A/G cg27661571 chr11:113659931 NA -0.96 -11.16 -0.52 1e-24 Hip circumference adjusted for BMI; CRC cis rs28655083 0.509 rs285020 chr16:77099517 C/G cg01753188 chr16:77233325 SYCE1L;MON1B 0.48 6.74 0.35 7.27e-11 Lobe attachment (rater-scored or self-reported); CRC cis rs6582630 0.502 rs7312212 chr12:38274760 T/G cg26384229 chr12:38710491 ALG10B 0.65 9.13 0.45 6.85e-18 Drug-induced liver injury (flucloxacillin); CRC cis rs2204008 0.616 rs1607852 chr12:38398125 G/A cg26384229 chr12:38710491 ALG10B 0.69 9.19 0.45 4.52e-18 Bladder cancer; CRC cis rs7953249 0.656 rs2178463 chr12:121389721 A/G cg02403541 chr12:121454288 C12orf43 -0.44 -6.41 -0.33 5.15e-10 Invasive epithelial ovarian cancer;High-grade serous ovarian cancer;Chronic obstructive pulmonary disease-related biomarkers;N-glycan levels;Serous invasive ovarian cancer;Epithelial ovarian cancer; CRC cis rs1348850 0.793 rs13000048 chr2:178337089 C/A cg22681709 chr2:178499509 PDE11A -0.36 -6.6 -0.34 1.6e-10 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs7618915 0.501 rs1866268 chr3:52719398 C/A cg10802521 chr3:52805072 NEK4 -0.58 -9.09 -0.45 9.57e-18 Bipolar disorder; CRC cis rs68170813 0.559 rs7794965 chr7:106826439 A/G cg23293999 chr7:106826042 HBP1 0.5 5.79 0.3 1.66e-8 Coronary artery disease; CRC cis rs7512552 0.803 rs13294 chr1:150484987 G/A cg15654264 chr1:150340011 RPRD2 0.56 7.93 0.4 3.41e-14 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); CRC cis rs457287 1.000 rs457287 chr9:4834394 A/G cg14182974 chr9:4791918 RCL1 0.41 6.55 0.34 2.25e-10 Platelet count; CRC cis rs3820068 0.656 rs72645829 chr1:15889748 A/G cg27534772 chr1:16042836 PLEKHM2 0.45 7.5 0.38 6.07e-13 Systolic blood pressure; CRC cis rs7072216 0.922 rs4488133 chr10:100159136 A/T cg26618903 chr10:100175079 PYROXD2 0.37 6.36 0.33 6.75e-10 Metabolite levels; CRC cis rs11676348 0.811 rs13027120 chr2:219020914 C/T cg00012203 chr2:219082015 ARPC2 0.43 6.58 0.34 1.83e-10 Ulcerative colitis; CRC cis rs1799949 1.000 rs1960605 chr17:41305397 C/T cg25072359 chr17:41440525 NA 0.46 6.96 0.36 1.84e-11 Menopause (age at onset); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg27242549 chr2:113012627 ZC3H8 0.39 6.2 0.32 1.72e-9 Liver disease severity in Alagille syndrome; CRC cis rs6693567 0.545 rs5011187 chr1:150422761 T/C cg15654264 chr1:150340011 RPRD2 0.42 6.25 0.33 1.29e-9 Migraine; CRC cis rs9311676 0.586 rs73085867 chr3:58434791 C/T cg06643156 chr3:58380774 PXK 0.43 6.65 0.34 1.19e-10 Systemic lupus erythematosus; CRC cis rs2811415 0.597 rs9810599 chr3:127749086 A/G cg13719885 chr3:127795394 NA -0.39 -5.96 -0.31 6.44e-9 Lung function (FEV1/FVC); CRC cis rs4474465 0.790 rs6592790 chr11:78262618 T/C cg02023728 chr11:77925099 USP35 -0.36 -6.15 -0.32 2.29e-9 Alzheimer's disease (survival time); CRC cis rs9388451 0.874 rs7739566 chr6:126094757 A/T cg10911889 chr6:126070802 HEY2 0.39 5.94 0.31 7.15e-9 Brugada syndrome; CRC trans rs951252 0.504 rs11734405 chr4:146081096 C/T cg27248073 chr17:6347727 FAM64A 0.46 6.19 0.32 1.78e-9 Hip circumference; CRC cis rs9467773 0.549 rs9461273 chr6:26584526 A/G cg09904177 chr6:26538194 HMGN4 -0.65 -9.9 -0.48 2.06e-20 Intelligence (multi-trait analysis); CRC cis rs1552244 1.000 rs7611218 chr3:10063960 T/C cg00166722 chr3:10149974 C3orf24 0.65 8.86 0.44 5.13e-17 Alzheimer's disease; CRC cis rs6964587 0.626 rs409 chr7:91556355 C/T cg17063962 chr7:91808500 NA 0.6 9.43 0.46 7.91e-19 Breast cancer; CRC cis rs7618915 0.547 rs11130311 chr3:52675005 T/C cg10802521 chr3:52805072 NEK4 -0.58 -9.0 -0.44 1.8e-17 Bipolar disorder; CRC cis rs10791323 0.604 rs2257010 chr11:133712348 G/A cg15485101 chr11:133734466 NA 0.45 7.58 0.39 3.44e-13 Childhood ear infection; CRC trans rs1728785 1.000 rs698712 chr16:68561879 G/A cg04657470 chr2:198365150 HSPE1;HSPD1 0.54 6.43 0.33 4.46e-10 Ulcerative colitis; CRC cis rs9612 1.000 rs346526 chr19:44259565 A/G cg08581076 chr19:44259116 C19orf61 0.49 6.28 0.33 1.06e-9 Exhaled nitric oxide output; CRC cis rs10991814 0.920 rs78704969 chr9:94118523 C/T cg14446406 chr9:93919335 NA 0.59 6.69 0.35 9.67e-11 Neutrophil percentage of granulocytes; CRC cis rs9322193 0.923 rs66516768 chr6:149993135 C/T cg13206674 chr6:150067644 NUP43 0.65 9.83 0.48 3.68e-20 Lung cancer; CRC trans rs1005277 0.579 rs2474584 chr10:38416389 C/T cg27523141 chr10:43048294 ZNF37B 0.49 7.18 0.37 4.79e-12 Extrinsic epigenetic age acceleration; CRC cis rs875971 0.964 rs778708 chr7:65856319 T/C cg00343986 chr7:65444356 GUSB 0.43 6.3 0.33 9.66e-10 Aortic root size; CRC cis rs7089973 0.872 rs60820172 chr10:116625891 C/T cg23260525 chr10:116636907 FAM160B1 0.31 6.75 0.35 6.66e-11 Bipolar disorder or attention deficit hyperactivity disorder; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg14532426 chr21:33245908 HUNK 0.36 6.4 0.33 5.46e-10 Liver disease severity in Alagille syndrome; CRC cis rs2228479 0.850 rs12598276 chr16:89829196 G/C cg06656553 chr16:89960601 TCF25 -0.7 -5.76 -0.3 1.93e-8 Skin colour saturation; CRC cis rs7727544 0.684 rs272893 chr5:131663062 T/C cg07395648 chr5:131743802 NA -0.38 -6.07 -0.32 3.54e-9 Blood metabolite levels; CRC cis rs4819052 0.808 rs11909411 chr21:46676556 A/C cg02159808 chr21:46707872 POFUT2;LOC642852 0.53 6.94 0.36 2.05e-11 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs7584330 0.554 rs10185109 chr2:238435546 T/C cg14458575 chr2:238380390 NA 0.44 6.49 0.34 3.09e-10 Prostate cancer; CRC cis rs3771570 0.901 rs9052 chr2:242434809 G/T cg21155796 chr2:242212141 HDLBP 0.55 6.38 0.33 6.02e-10 Prostate cancer; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg20337753 chr22:36424119 RBM9 0.41 6.37 0.33 6.55e-10 Response to antipsychotic treatment; CRC cis rs1448094 0.512 rs7953318 chr12:86245929 G/A cg00310523 chr12:86230176 RASSF9 0.35 5.93 0.31 7.63e-9 Major depressive disorder; CRC cis rs72772090 0.539 rs72773991 chr5:96163775 T/G cg17330273 chr5:96107758 CAST;ERAP1 -0.58 -5.66 -0.3 3.29e-8 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs7208859 0.623 rs35916850 chr17:29011173 G/A cg14008862 chr17:28927542 LRRC37B2 0.59 5.77 0.3 1.87e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs9287719 0.566 rs34595606 chr2:10722518 G/A cg00105475 chr2:10696890 NA 0.48 7.3 0.37 2.2e-12 Prostate cancer; CRC cis rs2204008 0.774 rs4534658 chr12:38246783 G/A cg13010199 chr12:38710504 ALG10B 0.45 5.89 0.31 9.46e-9 Bladder cancer; CRC cis rs3889199 0.924 rs35844581 chr1:59672968 G/T cg25881383 chr1:59680599 NA -0.38 -6.05 -0.32 4.05e-9 Pulse pressure; CRC cis rs9372498 0.505 rs62422247 chr6:118987559 G/T cg01339444 chr6:118972232 C6orf204 0.57 6.1 0.32 3.04e-9 Diastolic blood pressure; CRC cis rs970548 0.697 rs11239540 chr10:45999209 T/C cg15590007 chr10:45870220 ALOX5 0.61 6.02 0.31 4.79e-9 Total cholesterol levels;Cholesterol, total;HDL cholesterol;HDL cholesterol levels; CRC cis rs4713118 0.629 rs203887 chr6:28021269 C/T cg12172441 chr6:28176163 NA 0.47 5.63 0.3 3.92e-8 Parkinson's disease; CRC cis rs780094 0.544 rs780110 chr2:27685388 G/A cg12000995 chr2:27665139 KRTCAP3 -0.28 -5.85 -0.31 1.19e-8 Calcium levels;Fasting blood insulin;Metabolic traits;Triglyceride levels;Fasting plasma glucose;Urate levels in overweight individuals;Urate levels in obese individuals;Uric acid levels;Height;Age-related diseases, mortality and associated endophenotypes;Renal underexcretion gout;Fasting blood glucose (BMI interaction);Urate levels;Gondoic acid (20:1n-9) levels;Fasting blood insulin (BMI interaction);Triglycerides;Plasma omega-3 polyunsaturated fatty acid levels (docosapentaenoic acid);Type 2 diabetes;Nonalcoholic fatty liver disease;Hypertriglyceridemia;C-reactive protein;Age-related disease endophenotypes;LDL cholesterol;Metabolic syndrome;Crohn's disease;Alcohol consumption (drinks per week);Homeostasis model assessment of insulin resistance;Alcohol consumption;Red blood cell count;Fasting blood glucose; CRC cis rs5753618 0.561 rs4820043 chr22:31647094 A/G cg22777020 chr22:31556080 RNF185 -0.48 -5.74 -0.3 2.15e-8 Colorectal cancer; CRC cis rs6667605 0.527 rs6673993 chr1:2552071 T/C cg18854424 chr1:2615690 NA 0.48 9.62 0.47 1.81e-19 Inflammatory bowel disease;Ulcerative colitis; CRC cis rs2180341 0.538 rs11154402 chr6:127711932 C/A cg24812749 chr6:127587940 RNF146 0.49 7.18 0.37 4.56e-12 Breast cancer; CRC cis rs9818758 0.607 rs13068038 chr3:49294250 C/A cg00383909 chr3:49044727 WDR6 1.12 10.8 0.51 1.76e-23 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg05482832 chr17:74734106 MIR636;SFRS2;MFSD11 0.39 5.98 0.31 5.86e-9 Intelligence (multi-trait analysis); CRC cis rs60843830 1.000 rs62114497 chr2:214837 G/A cg25945732 chr2:264204 ACP1;SH3YL1 0.72 11.15 0.52 1.03e-24 Spherical equivalent (joint analysis main effects and education interaction); CRC cis rs1046896 0.739 rs2379358 chr17:80741612 G/A cg02398342 chr17:80708632 TBCD;FN3K 0.41 5.91 0.31 8.35e-9 Glycated hemoglobin levels; CRC cis rs3849570 0.925 rs7641973 chr3:81910489 G/A cg07356753 chr3:81810745 GBE1 -0.65 -9.52 -0.46 3.76e-19 Waist circumference;Body mass index; CRC cis rs10256972 0.869 rs4720158 chr7:1040325 A/G cg03923535 chr7:1197113 ZFAND2A 0.41 5.69 0.3 2.81e-8 Longevity;Endometriosis; CRC cis rs9311474 0.508 rs4687546 chr3:52605943 T/A cg08222913 chr3:52553049 STAB1 -0.34 -6.45 -0.34 4e-10 Electroencephalogram traits; CRC cis rs2274273 0.600 rs10134317 chr14:55793448 C/T cg10130446 chr14:55658398 DLGAP5 -0.42 -5.88 -0.31 1.01e-8 Protein biomarker; CRC cis rs447 0.666 rs10279093 chr7:83748678 T/G cg22846510 chr7:83753280 SEMA3A -0.42 -5.83 -0.31 1.33e-8 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs10751667 0.961 rs7482484 chr11:927020 C/T ch.11.42038R chr11:967971 AP2A2 0.71 11.92 0.55 1.83e-27 Alzheimer's disease (late onset); CRC cis rs6598955 0.724 rs10902731 chr1:26600793 A/G cg04990556 chr1:26633338 UBXN11 -0.78 -13.06 -0.58 1.06e-31 Obesity-related traits; CRC cis rs951366 0.559 rs823101 chr1:205667006 T/C cg23034840 chr1:205782522 SLC41A1 0.44 5.81 0.31 1.46e-8 Menarche (age at onset); CRC trans rs12310956 0.532 rs1852226 chr12:33962940 G/A cg26384229 chr12:38710491 ALG10B 0.46 6.32 0.33 8.5e-10 Morning vs. evening chronotype; CRC cis rs12148488 0.816 rs4886655 chr15:75385568 C/T cg14664628 chr15:75095509 CSK -0.44 -6.54 -0.34 2.28e-10 Caffeine consumption; CRC cis rs1997103 0.954 rs9649854 chr7:55410213 G/A cg17469321 chr7:55412551 NA 0.72 11.23 0.53 5.64e-25 QRS interval (sulfonylurea treatment interaction); CRC cis rs10504229 0.609 rs66477547 chr8:58105763 A/C cg05313129 chr8:58192883 C8orf71 -0.43 -5.72 -0.3 2.37e-8 Developmental language disorder (linguistic errors); CRC cis rs2949837 0.581 rs1117457 chr7:45970037 G/A cg21268650 chr7:45961089 IGFBP3 0.36 6.12 0.32 2.66e-9 Sitting height ratio; CRC cis rs561341 0.882 rs111484028 chr17:30287701 G/A cg00745463 chr17:30367425 LRRC37B -0.75 -9.09 -0.45 9.8e-18 Hip circumference adjusted for BMI; CRC cis rs9457247 0.534 rs2345568 chr6:167381804 A/G cg23791538 chr6:167370224 RNASET2 0.48 7.62 0.39 2.65e-13 Crohn's disease; CRC trans rs2303319 0.504 rs72877343 chr2:162607487 A/C cg20024234 chr21:43431083 ZNF295 -0.66 -5.99 -0.31 5.57e-9 Cognitive function; CRC trans rs9329221 0.592 rs7832708 chr8:10190040 C/T cg06636001 chr8:8085503 FLJ10661 0.62 9.8 0.48 4.71e-20 Neuroticism; CRC cis rs7918232 0.882 rs2149413 chr10:27430311 C/T cg14442939 chr10:27389572 ANKRD26 -0.81 -9.05 -0.45 1.25e-17 Breast cancer; CRC cis rs801193 0.660 rs10950049 chr7:66230860 T/C cg18912574 chr7:65842487 NCRNA00174 0.36 6.09 0.32 3.24e-9 Aortic root size; CRC cis rs425277 0.500 rs908744 chr1:2038893 G/A cg24578937 chr1:2090814 PRKCZ -0.38 -7.0 -0.36 1.45e-11 Height; CRC cis rs6456156 1.000 rs7761159 chr6:167519907 T/A cg05540913 chr6:167530185 CCR6 0.32 5.67 0.3 3.19e-8 Primary biliary cholangitis; CRC cis rs2732480 0.500 rs7315820 chr12:48598938 C/T cg04545296 chr12:48745243 ZNF641 0.33 5.83 0.31 1.35e-8 Hemoglobin concentration;Red blood cell count;Hematocrit; CRC cis rs10771431 0.810 rs10771418 chr12:9358995 A/G cg08997352 chr12:9597637 DDX12 -0.5 -7.69 -0.39 1.73e-13 Breast size; CRC trans rs4650994 0.905 rs12753251 chr1:178529898 G/A cg05059571 chr16:84539110 KIAA1609 -0.45 -6.94 -0.36 2.08e-11 HDL cholesterol levels;HDL cholesterol; CRC cis rs2243480 1.000 rs1392104 chr7:65759107 G/A cg18252515 chr7:66147081 NA 1.27 14.66 0.63 8.59e-38 Diabetic kidney disease; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg14127958 chr12:105630059 APPL2 0.45 6.11 0.32 2.75e-9 Anxiety disorder; CRC cis rs9916302 0.904 rs10852933 chr17:37698194 G/T cg00129232 chr17:37814104 STARD3 -0.55 -8.14 -0.41 8.5e-15 Glomerular filtration rate (creatinine); CRC cis rs6681460 0.966 rs11208932 chr1:67097853 T/C cg02459107 chr1:67143332 SGIP1 0.45 7.54 0.38 4.66e-13 Presence of antiphospholipid antibodies; CRC cis rs4862750 0.872 rs56389997 chr4:187894796 A/C cg03647317 chr4:187891568 NA -0.54 -10.03 -0.48 7.81e-21 Lobe attachment (rater-scored or self-reported); CRC cis rs738321 0.757 rs9622732 chr22:38524149 G/C cg25457927 chr22:38595422 NA -0.33 -6.22 -0.32 1.53e-9 Breast cancer; CRC cis rs3733585 0.699 rs7694997 chr4:9947811 A/G cg00071950 chr4:10020882 SLC2A9 -0.56 -9.82 -0.48 3.87e-20 Cleft plate (environmental tobacco smoke interaction); CRC trans rs9581094 0.527 rs73172130 chr13:25024985 A/G ch.10.2420334F chr10:115122200 NA 0.74 6.22 0.32 1.54e-9 Sudden cardiac arrest; CRC cis rs875971 0.964 rs6945032 chr7:65922486 C/T cg18912574 chr7:65842487 NCRNA00174 0.36 6.1 0.32 2.97e-9 Aortic root size; CRC trans rs875971 0.660 rs2191268 chr7:66110224 C/T cg05586854 chr2:149402972 EPC2 -0.41 -6.27 -0.33 1.15e-9 Aortic root size; CRC cis rs6570726 0.791 rs7765675 chr6:145915077 A/C cg05347473 chr6:146136440 FBXO30 0.39 5.89 0.31 9.49e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs12692738 0.526 rs355868 chr2:165631194 C/T cg03182029 chr2:165697222 COBLL1 0.5 5.86 0.31 1.11e-8 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);Waist-to-hip ratio adjusted for BMI in non-smokers;Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction);Waist-to-hip ratio adjusted for body mass index; CRC cis rs8180040 0.966 rs807932 chr3:47354241 C/T cg02527881 chr3:46936655 PTH1R -0.39 -7.55 -0.38 4.19e-13 Colorectal cancer; CRC cis rs2758596 0.850 rs2495270 chr1:156181530 A/G cg24450063 chr1:156163899 SLC25A44 0.71 6.3 0.33 9.46e-10 Paclitaxel disposition in epithelial ovarian cancer; CRC cis rs17092148 1.000 rs11699062 chr20:33400379 A/T cg08999081 chr20:33150536 PIGU -0.42 -5.62 -0.3 4.16e-8 Neuroticism; CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg02996269 chr4:106394692 PPA2 0.4 6.24 0.33 1.36e-9 Obesity-related traits; CRC cis rs9372498 0.536 rs13437605 chr6:118899014 C/T cg01339444 chr6:118972232 C6orf204 0.56 6.27 0.33 1.16e-9 Diastolic blood pressure; CRC cis rs9814567 1.000 rs6765505 chr3:134208132 A/G cg06109529 chr3:134205091 CEP63;ANAPC13 -0.81 -12.3 -0.56 7.02e-29 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs3736594 0.546 rs6719960 chr2:27830067 C/T cg27432699 chr2:27873401 GPN1 -0.61 -8.12 -0.41 9.14e-15 Fasting blood glucose;Fasting blood glucose (BMI interaction); CRC cis rs2370759 1.000 rs16933243 chr10:32615135 T/C cg01819863 chr10:32635814 EPC1 1.12 13.62 0.6 8.03e-34 Sexual dysfunction (female); CRC cis rs9488822 0.676 rs12202181 chr6:116327102 A/G cg05304507 chr6:116381966 FRK 0.3 8.24 0.41 4.08e-15 Cholesterol, total;LDL cholesterol; CRC cis rs6062302 0.522 rs2872810 chr20:62241931 C/T cg09650180 chr20:62225654 GMEB2 0.5 6.75 0.35 6.69e-11 Glioblastoma; CRC cis rs28386778 1.000 rs2665851 chr17:61957023 T/C cg23090583 chr17:61904693 PSMC5;FTSJ3 1.01 19.11 0.73 2.73e-55 Prudent dietary pattern; CRC cis rs9443645 0.901 rs9352664 chr6:79566162 G/T cg11833968 chr6:79620685 NA -0.35 -6.15 -0.32 2.23e-9 Intelligence (multi-trait analysis); CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg08209163 chr13:28024472 MTIF3 0.38 6.17 0.32 1.96e-9 Obesity-related traits; CRC cis rs6741819 0.617 rs56155927 chr2:7159401 A/C cg27144453 chr2:7172511 RNF144A -0.59 -7.71 -0.39 1.55e-13 Response to antipsychotic treatment; CRC cis rs4974559 1.000 rs1882099 chr4:1352685 A/G cg02980000 chr4:1222292 CTBP1 0.56 7.49 0.38 6.53e-13 Systolic blood pressure; CRC cis rs4727027 0.933 rs12704063 chr7:148827909 T/C cg23583168 chr7:148888333 NA -0.93 -16.32 -0.67 2.74e-44 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC cis rs2072510 0.569 rs7306086 chr12:96390502 T/C cg22491680 chr12:96389547 HAL -0.5 -6.16 -0.32 2.16e-9 Metabolite levels (small molecules and protein measures); CRC cis rs12701220 0.655 rs34344742 chr7:1149288 C/G cg26240231 chr7:1148101 C7orf50 -0.44 -6.41 -0.33 5.16e-10 Bronchopulmonary dysplasia; CRC cis rs7666738 0.687 rs6830176 chr4:99093955 G/C cg05340658 chr4:99064831 C4orf37 0.49 7.17 0.37 5.06e-12 Colonoscopy-negative controls vs population controls; CRC cis rs7945718 0.935 rs1609442 chr11:12795418 T/A cg25843174 chr11:12811716 TEAD1 0.5 9.46 0.46 6.3e-19 Educational attainment (years of education); CRC cis rs801193 1.000 rs7788576 chr7:66148302 G/A cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.44 -6.43 -0.33 4.52e-10 Aortic root size; CRC cis rs4665809 0.590 rs3806514 chr2:26466772 C/T cg26119090 chr2:26468346 HADHA;HADHB 1.0 14.65 0.63 8.89e-38 Gut microbiome composition (summer); CRC cis rs4588572 0.644 rs6870646 chr5:77741082 G/A cg11446398 chr5:77624930 NA 0.41 5.92 0.31 8.16e-9 Triglycerides; CRC cis rs72781680 0.611 rs2111884 chr2:24289472 A/T cg20701182 chr2:24300061 SF3B14 0.66 7.63 0.39 2.52e-13 Lymphocyte counts; CRC cis rs9291683 0.566 rs13115776 chr4:10040189 C/G cg00071950 chr4:10020882 SLC2A9 0.63 11.33 0.53 2.47e-25 Bone mineral density; CRC cis rs73195822 0.614 rs7309777 chr12:111213964 A/G cg12870014 chr12:110450643 ANKRD13A 0.57 5.76 0.3 1.94e-8 Itch intensity from mosquito bite; CRC cis rs7552404 0.696 rs10518521 chr1:76461214 G/A cg10523679 chr1:76189770 ACADM 0.76 8.46 0.42 8.66e-16 Blood metabolite levels;Acylcarnitine levels; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg12184888 chr8:120886450 DEPDC6 0.41 5.98 0.31 5.68e-9 Intelligence (multi-trait analysis); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg20531781 chr7:99775012 STAG3;GPC2 0.4 6.64 0.34 1.29e-10 Liver disease severity in Alagille syndrome; CRC cis rs765787 0.530 rs28414644 chr15:45536721 G/C cg24006582 chr15:45444508 DUOX1 -0.57 -8.66 -0.43 2.13e-16 Uric acid levels; CRC cis rs597539 0.654 rs7107137 chr11:68623712 A/G cg06028808 chr11:68637592 NA 0.41 6.23 0.32 1.45e-9 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs9916302 0.861 rs593480 chr17:37453780 A/C cg07936489 chr17:37558343 FBXL20 0.76 11.16 0.52 9.43e-25 Glomerular filtration rate (creatinine); CRC trans rs9858542 1.000 rs9836291 chr3:49697459 G/A cg21659725 chr3:3221576 CRBN -0.63 -8.24 -0.41 4.25e-15 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC trans rs1728785 0.901 rs933713 chr16:68581378 C/A cg04657470 chr2:198365150 HSPE1;HSPD1 0.58 7.07 0.36 9.08e-12 Ulcerative colitis; CRC cis rs921968 0.528 rs13382651 chr2:219628191 A/G cg02176678 chr2:219576539 TTLL4 -0.39 -6.32 -0.33 8.67e-10 Mean corpuscular hemoglobin concentration; CRC cis rs6951245 0.935 rs118132455 chr7:1068232 C/A cg20603222 chr7:1096387 C7orf50;GPR146 -0.69 -8.1 -0.41 1.07e-14 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs3825932 0.961 rs11072815 chr15:79232319 C/T cg25744700 chr15:79237217 CTSH -0.38 -5.86 -0.31 1.11e-8 Type 1 diabetes; CRC cis rs12451471 0.500 rs8077056 chr17:78076006 C/T cg08347473 chr17:78092826 GAA -0.38 -6.43 -0.33 4.5e-10 Plateletcrit;Mean corpuscular hemoglobin concentration; CRC trans rs2243480 1.000 rs56985706 chr7:65394562 C/T cg10756647 chr7:56101905 PSPH 0.73 8.07 0.41 1.36e-14 Diabetic kidney disease; CRC cis rs9435341 0.929 rs1730865 chr1:107605611 A/C cg11070056 chr1:107600091 PRMT6 0.4 5.81 0.31 1.44e-8 Facial morphology (factor 21, depth of nasal alae); CRC cis rs17433780 1.000 rs17433780 chr1:89474818 C/T cg09516651 chr1:89888402 LOC400759 -0.44 -6.77 -0.35 5.87e-11 Carotid intima media thickness; CRC trans rs2243480 1.000 rs34970380 chr7:65431493 C/T cg10756647 chr7:56101905 PSPH 0.69 7.51 0.38 5.5e-13 Diabetic kidney disease; CRC cis rs763121 0.853 rs2281019 chr22:39064378 T/A cg06544989 chr22:39130855 UNC84B 0.46 7.11 0.37 7.19e-12 Menopause (age at onset); CRC cis rs6973256 0.605 rs7794168 chr7:133357606 T/C cg10665199 chr7:133106180 EXOC4 0.49 7.81 0.4 7.78e-14 Intelligence (multi-trait analysis); CRC cis rs7811142 1.000 rs4989959 chr7:100032288 T/C cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.98 13.51 0.6 2.08e-33 Platelet count; CRC trans rs10507419 1.000 rs9541352 chr13:35182031 C/A cg00944431 chr1:10896004 NA 0.42 6.03 0.32 4.34e-9 Immunoglobulin light chain (AL) amyloidosis (serum Ig lambda profile);Immunoglobulin light chain (AL) amyloidosis (serum IgG profile); CRC cis rs10464366 0.544 rs6952466 chr7:39155032 A/T cg18850127 chr7:39170497 POU6F2 0.57 7.74 0.39 1.2e-13 IgG glycosylation; CRC cis rs96067 0.805 rs4653162 chr1:36613704 G/T cg25304816 chr1:36627734 MAP7D1 -0.46 -6.67 -0.35 1.06e-10 Corneal structure; CRC cis rs12477438 0.501 rs17759607 chr2:99737005 T/C cg26064155 chr2:99771622 LIPT1;TSGA10 0.78 13.46 0.6 3.33e-33 Chronic sinus infection; CRC cis rs8180040 0.902 rs73081205 chr3:47517670 A/C cg27129171 chr3:47204927 SETD2 -0.61 -9.45 -0.46 6.48e-19 Colorectal cancer; CRC cis rs4594175 0.926 rs4318127 chr14:51624897 G/C cg23942311 chr14:51606299 NA 0.64 10.58 0.5 1.03e-22 Cancer; CRC cis rs12540874 0.698 rs13234331 chr7:50560314 G/T cg18232548 chr7:50535776 DDC -0.55 -8.22 -0.41 4.65e-15 Systemic sclerosis; CRC cis rs798554 0.797 rs798488 chr7:2802522 T/C cg04166393 chr7:2884313 GNA12 0.51 6.8 0.35 4.86e-11 Height; CRC cis rs4805272 0.512 rs66830923 chr19:29321277 C/T cg12667521 chr19:29218732 NA 0.47 6.65 0.34 1.2e-10 Plasma omega-3 polyunsaturated fatty acid levels (docosahexaenoic acid); CRC cis rs9818758 0.607 rs13077498 chr3:49313978 C/T cg07636037 chr3:49044803 WDR6 -0.79 -6.62 -0.34 1.49e-10 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; CRC cis rs747650 0.504 rs10838640 chr11:46984629 C/T cg19486271 chr11:47235900 DDB2 -0.43 -6.47 -0.34 3.53e-10 Acne (severe); CRC cis rs13191362 1.000 rs35818596 chr6:163001874 C/G cg21926612 chr6:163149169 PACRG;PARK2 0.8 11.25 0.53 4.59e-25 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs861020 0.582 rs630065 chr1:209998662 C/T cg09163369 chr1:210001066 C1orf107 0.4 5.62 0.3 4e-8 Orofacial clefts; CRC cis rs2153535 0.580 rs6905242 chr6:8471799 A/C cg07606381 chr6:8435919 SLC35B3 0.67 10.82 0.51 1.52e-23 Motion sickness; CRC cis rs1577917 1.000 rs34852683 chr6:86702330 T/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.51 -6.77 -0.35 5.76e-11 Response to antipsychotic treatment; CRC cis rs7927771 0.770 rs11039203 chr11:47384597 A/G cg20307385 chr11:47447363 PSMC3 -0.63 -9.19 -0.45 4.47e-18 Subjective well-being; CRC cis rs2204008 0.682 rs2320517 chr12:38259239 A/T cg13010199 chr12:38710504 ALG10B 0.45 5.75 0.3 2.07e-8 Bladder cancer; CRC trans rs11098499 0.863 rs11731756 chr4:120478696 T/G cg25214090 chr10:38739885 LOC399744 0.66 10.41 0.5 4.04e-22 Corneal astigmatism; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg00334798 chr11:72929553 P2RY2 0.38 6.14 0.32 2.42e-9 Liver disease severity in Alagille syndrome; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg02114082 chr10:12306459 NA 0.44 6.36 0.33 6.59e-10 Response to antipsychotic treatment; CRC cis rs7584330 0.518 rs78856668 chr2:238438055 A/C cg08992911 chr2:238395768 MLPH 0.6 6.14 0.32 2.44e-9 Prostate cancer; CRC cis rs9435341 0.965 rs9435441 chr1:107603330 C/G cg15468180 chr1:107600409 PRMT6 -0.38 -6.06 -0.32 3.7e-9 Facial morphology (factor 21, depth of nasal alae); CRC cis rs8177253 0.763 rs8177224 chr3:133474003 C/G cg01448562 chr3:133502909 NA 0.48 7.77 0.39 1.02e-13 Iron status biomarkers; CRC cis rs57994353 0.828 rs11146021 chr9:139327858 A/G cg14119001 chr9:139324193 INPP5E 0.42 6.11 0.32 2.86e-9 Eosinophil counts;Cutaneous squamous cell carcinoma; CRC cis rs11214589 0.747 rs11214582 chr11:113218050 C/T cg14159747 chr11:113255604 NA 0.47 8.68 0.43 1.84e-16 Neuroticism; CRC cis rs896854 0.875 rs4735333 chr8:95955074 G/A cg23172400 chr8:95962367 TP53INP1 -0.48 -8.17 -0.41 6.7e-15 Type 2 diabetes; CRC cis rs2839186 0.732 rs55904887 chr21:47707811 A/G cg02776659 chr21:47717406 C21orf57 -0.34 -5.62 -0.3 4.13e-8 Testicular germ cell tumor; CRC cis rs1552244 0.572 rs12107622 chr3:10171898 T/A cg00166722 chr3:10149974 C3orf24 0.69 8.15 0.41 7.57e-15 Alzheimer's disease; CRC cis rs6582630 0.537 rs1851124 chr12:38516404 G/A cg13010199 chr12:38710504 ALG10B 0.48 6.46 0.34 3.84e-10 Drug-induced liver injury (flucloxacillin); CRC cis rs12325245 0.536 rs71375919 chr16:58547522 C/T cg02549819 chr16:58548995 SETD6 1.2 7.85 0.4 5.77e-14 Schizophrenia; CRC cis rs116095464 0.510 rs55750776 chr5:230467 T/C cg22857025 chr5:266934 NA -1.21 -16.45 -0.67 8.87e-45 Breast cancer; CRC cis rs4481887 0.927 rs4376768 chr1:248476088 A/G cg00666640 chr1:248458726 OR2T12 -0.45 -7.76 -0.39 1.1e-13 Common traits (Other); CRC cis rs7119 0.717 rs12904212 chr15:77815833 C/A cg27398640 chr15:77910606 LINGO1 -0.43 -7.44 -0.38 8.96e-13 Type 2 diabetes; CRC cis rs55702914 0.967 rs61328028 chr2:198223754 A/G cg10820045 chr2:198174542 NA 0.35 6.04 0.32 4.15e-9 Major depression and alcohol dependence; CRC cis rs3858526 0.959 rs1840179 chr11:5949148 A/G cg26762873 chr11:5879799 OR52E8 -0.41 -6.02 -0.32 4.57e-9 DNA methylation (variation); CRC cis rs728616 0.867 rs55690691 chr10:81658942 G/T cg11900509 chr10:81946545 ANXA11 -0.62 -6.31 -0.33 8.96e-10 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs2075165 0.935 rs933489 chr1:156235120 T/C cg20302342 chr1:156215951 PAQR6 0.41 8.19 0.41 5.97e-15 Tonsillectomy; CRC cis rs7811142 1.000 rs4463351 chr7:100078226 G/A cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.6 7.7 0.39 1.62e-13 Platelet count; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg11395536 chr1:150521958 ADAMTSL4 0.38 6.45 0.34 4.02e-10 Liver disease severity in Alagille syndrome; CRC cis rs10504229 0.679 rs11783444 chr8:58131267 A/G cg02725872 chr8:58115012 NA -0.64 -11.55 -0.54 3.85e-26 Developmental language disorder (linguistic errors); CRC cis rs2735413 0.711 rs12921476 chr16:78079846 G/C cg04733911 chr16:78082701 NA -0.45 -7.24 -0.37 3.26e-12 Systolic blood pressure (alcohol consumption interaction); CRC cis rs7586879 0.638 rs13035244 chr2:25134009 T/C cg22495460 chr2:25135724 ADCY3 -0.89 -17.5 -0.69 6.3e-49 Body mass index; CRC cis rs9311676 0.609 rs62258077 chr3:58363371 T/C cg06643156 chr3:58380774 PXK 0.44 6.8 0.35 4.98e-11 Systemic lupus erythematosus; CRC cis rs2836974 0.897 rs14194 chr21:40549466 T/C cg11890956 chr21:40555474 PSMG1 1.08 18.29 0.71 4.62e-52 Cognitive function; CRC cis rs9916302 0.904 rs6503507 chr17:37525274 C/T cg15445000 chr17:37608096 MED1 -0.44 -9.71 -0.47 9.39e-20 Glomerular filtration rate (creatinine); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg07625546 chr4:78077996 CCNG2 0.46 6.33 0.33 8.09e-10 Response to antipsychotic treatment; CRC cis rs873917 0.577 rs784611 chr1:40125988 T/A cg06209491 chr1:40138402 NT5C1A -0.48 -7.5 -0.38 6.18e-13 Amyotrophic lateral sclerosis; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg22629493 chr21:34961221 DONSON 0.44 6.04 0.32 4.09e-9 Anxiety disorder; CRC cis rs6484504 0.532 rs12222329 chr11:31274340 T/C cg14844989 chr11:31128820 NA -0.34 -5.96 -0.31 6.62e-9 Red blood cell count; CRC cis rs7917772 0.503 rs7896841 chr10:104294665 C/T cg11453585 chr10:104263688 ACTR1A;SUFU 0.9 16.75 0.68 5.87e-46 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC cis rs344364 0.511 rs1742469 chr16:1950244 C/T cg09830162 chr16:1889614 FAHD1;C16orf73 -0.77 -9.36 -0.46 1.32e-18 Glomerular filtration rate in chronic kidney disease; CRC cis rs10463316 0.817 rs11167545 chr5:150778076 C/T cg03212797 chr5:150827313 SLC36A1 -0.47 -7.25 -0.37 3.04e-12 Metabolite levels (Pyroglutamine); CRC cis rs1552244 0.882 rs13062917 chr3:10017032 T/A cg08888203 chr3:10149979 C3orf24 0.62 8.23 0.41 4.29e-15 Alzheimer's disease; CRC trans rs2303319 0.504 rs12467625 chr2:162603387 C/A cg22627826 chr19:1240265 ATP5D -0.72 -6.24 -0.33 1.32e-9 Cognitive function; CRC cis rs3858526 0.508 rs10838734 chr11:5876325 T/G cg05234568 chr11:5960015 NA -0.63 -9.23 -0.45 3.33e-18 DNA methylation (variation); CRC cis rs7591163 1.000 rs1721359 chr2:228751874 C/T cg14329157 chr2:228736135 WDR69 -0.47 -6.51 -0.34 2.73e-10 Blood pressure; CRC cis rs10540 1.000 rs116876680 chr11:517473 G/T cg19913688 chr11:428466 ANO9 -0.68 -7.0 -0.36 1.44e-11 Body mass index; CRC cis rs2019137 0.560 rs7578633 chr2:113978650 C/T cg21550016 chr2:113992930 PAX8;LOC440839;LOC654433 0.7 10.51 0.5 1.82e-22 Lymphocyte counts; CRC trans rs800082 1.000 rs1007564 chr3:144311843 C/T cg24215973 chr2:240111563 HDAC4 -0.52 -7.28 -0.37 2.53e-12 Smoking behavior; CRC cis rs2228479 0.867 rs11645970 chr16:89958118 G/A cg06656553 chr16:89960601 TCF25 -0.64 -5.82 -0.31 1.39e-8 Skin colour saturation; CRC cis rs9527 0.590 rs3781282 chr10:104852419 C/T cg15744005 chr10:104629667 AS3MT 0.31 6.13 0.32 2.47e-9 Arsenic metabolism; CRC cis rs561341 1.000 rs15654 chr17:30326360 A/C cg00745463 chr17:30367425 LRRC37B -0.88 -9.71 -0.47 9.33e-20 Hip circumference adjusted for BMI; CRC cis rs9291683 0.655 rs35750364 chr4:10049049 T/C cg00071950 chr4:10020882 SLC2A9 0.67 12.76 0.58 1.38e-30 Bone mineral density; CRC trans rs2727020 0.681 rs1976901 chr11:49378697 T/C cg15704280 chr7:45808275 SEPT13 -0.89 -16.27 -0.67 4.29e-44 Coronary artery disease; CRC cis rs10256972 0.577 rs2949179 chr7:1209885 C/G cg27094323 chr7:1216898 NA -0.45 -7.58 -0.39 3.62e-13 Longevity;Endometriosis; CRC cis rs2742540 0.503 rs11042121 chr11:8932640 A/C cg14711859 chr11:8959438 ASCL3 -0.56 -10.65 -0.51 5.83e-23 Hematocrit; CRC cis rs651907 0.557 rs7629753 chr3:101371922 C/T cg03837452 chr3:101395095 ZBTB11;LOC100009676 -0.69 -9.7 -0.47 9.55e-20 Colorectal cancer; CRC cis rs847577 0.630 rs3801294 chr7:97822210 G/A cg00277769 chr7:97922759 BAIAP2L1 -0.41 -6.88 -0.35 2.99e-11 Breast cancer; CRC cis rs6502050 0.799 rs11491185 chr17:80151101 C/T cg25804541 chr17:80189381 SLC16A3 -0.31 -5.9 -0.31 8.81e-9 Life satisfaction; CRC cis rs72634258 0.503 rs71637401 chr1:7837012 G/A cg26816564 chr1:7831052 VAMP3 0.9 9.91 0.48 1.91e-20 Inflammatory bowel disease; CRC cis rs10479542 0.766 rs6894980 chr5:178974592 C/T cg09060608 chr5:178986726 RUFY1 0.39 6.24 0.33 1.31e-9 Lung cancer; CRC cis rs9768139 0.708 rs921616 chr7:158117960 A/G cg06219351 chr7:158114137 PTPRN2 -0.55 -8.34 -0.42 2.11e-15 Calcium levels; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg22225685 chr22:38203998 GCAT 0.46 7.46 0.38 7.74e-13 Liver disease severity in Alagille syndrome; CRC cis rs728616 0.867 rs61858980 chr10:81816618 G/A cg05935833 chr10:81318306 SFTPA2 -0.5 -6.13 -0.32 2.48e-9 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs2075371 0.796 rs1643040 chr7:134011703 G/C cg02659138 chr7:134003124 SLC35B4 0.39 6.7 0.35 9.14e-11 Mean platelet volume; CRC cis rs9467711 0.606 rs16891725 chr6:26479150 C/T cg08501292 chr6:25962987 TRIM38 0.68 5.64 0.3 3.58e-8 Autism spectrum disorder or schizophrenia; CRC cis rs1218582 0.772 rs2335408 chr1:154915977 G/A cg03351412 chr1:154909251 PMVK 0.53 8.38 0.42 1.59e-15 Prostate cancer; CRC trans rs2797160 1.000 rs6934435 chr6:126017481 T/G cg05039488 chr6:79577232 IRAK1BP1 0.51 7.6 0.39 3.19e-13 Endometrial cancer; CRC cis rs4713118 0.513 rs149955 chr6:28036225 G/C cg25164649 chr6:28176230 NA 0.61 8.61 0.43 3.05e-16 Parkinson's disease; CRC cis rs12024301 0.557 rs7530294 chr1:183610416 T/C cg11505048 chr1:183622726 RGL1;APOBEC4 0.81 7.0 0.36 1.42e-11 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs6570726 0.935 rs385185 chr6:145814992 A/G cg23711669 chr6:146136114 FBXO30 0.68 12.05 0.55 6.18e-28 Lobe attachment (rater-scored or self-reported); CRC cis rs270601 0.661 rs10036208 chr5:131571323 T/C cg04518342 chr5:131593106 PDLIM4 0.58 9.99 0.48 1.06e-20 Acylcarnitine levels; CRC cis rs7615952 0.641 rs4422257 chr3:125774363 A/G cg06494592 chr3:125709126 NA -0.56 -6.73 -0.35 7.33e-11 Blood pressure (smoking interaction); CRC cis rs2840044 1.000 rs9900378 chr17:33911302 C/T cg05299278 chr17:33885742 SLFN14 -0.4 -6.08 -0.32 3.39e-9 Response to radiotherapy in cancer (late toxicity); CRC cis rs9325144 0.723 rs11169518 chr12:39177237 C/A cg26384229 chr12:38710491 ALG10B -0.43 -5.77 -0.3 1.82e-8 Morning vs. evening chronotype; CRC cis rs12893668 0.628 rs57072546 chr14:104063723 T/C cg08213375 chr14:104286397 PPP1R13B 0.4 6.38 0.33 5.93e-10 Reticulocyte count; CRC cis rs7586879 0.681 rs6705446 chr2:25118608 T/C cg22495460 chr2:25135724 ADCY3 -0.87 -17.11 -0.69 2.25e-47 Body mass index; CRC cis rs4665809 0.887 rs6546716 chr2:26263836 A/G cg22920501 chr2:26401640 FAM59B -0.52 -7.12 -0.37 6.67e-12 Gut microbiome composition (summer); CRC cis rs2991971 0.933 rs666720 chr1:46020795 T/C cg24296786 chr1:45957014 TESK2 0.48 6.82 0.35 4.43e-11 High light scatter reticulocyte count; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg19239571 chr1:100503607 HIAT1 0.39 6.84 0.35 3.83e-11 Liver disease severity in Alagille syndrome; CRC cis rs1800682 0.528 rs3903454 chr10:90743434 A/T cg03111039 chr10:90751583 FAS;ACTA2 0.77 11.64 0.54 1.92e-26 Chronic lymphocytic leukemia; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg17144508 chr2:128283727 IWS1 0.37 5.96 0.31 6.52e-9 Liver disease severity in Alagille syndrome; CRC cis rs875971 0.522 rs2949690 chr7:65483242 C/T cg11764359 chr7:65958608 NA -0.52 -7.82 -0.4 7.21e-14 Aortic root size; CRC cis rs1881797 0.932 rs10925071 chr1:247686521 C/T cg05639522 chr1:247681581 NA -0.51 -8.58 -0.43 3.81e-16 Acute lymphoblastic leukemia (childhood); CRC trans rs10983614 1.000 rs7867776 chr9:120072627 A/G cg01921777 chr1:40839564 SMAP2 0.47 6.47 0.34 3.63e-10 Survival in pancreatic cancer; CRC cis rs13256369 0.950 rs13270006 chr8:8574197 C/A cg17143192 chr8:8559678 CLDN23 0.47 6.16 0.32 2.08e-9 Obesity-related traits; CRC trans rs10506458 1.000 rs1495013 chr12:63428188 C/T cg22491629 chr6:157744540 C6orf35 -0.7 -8.21 -0.41 4.94e-15 Hemostatic factors and hematological phenotypes; CRC cis rs1448094 0.512 rs7308229 chr12:86239849 A/T cg18827107 chr12:86230957 RASSF9 0.44 6.99 0.36 1.55e-11 Major depressive disorder; CRC cis rs427941 0.632 rs201508 chr7:101764199 T/G cg06246474 chr7:101738831 CUX1 0.44 6.81 0.35 4.75e-11 Plasma omega-3 polyunsaturated fatty acid level (eicosapentaenoic acid); CRC cis rs12618769 0.652 rs3754878 chr2:99179384 G/A cg18455616 chr2:99124870 INPP4A 0.36 5.87 0.31 1.07e-8 Bipolar disorder; CRC cis rs1218582 0.710 rs4845685 chr1:154878300 C/A cg06221963 chr1:154839813 KCNN3 -0.76 -15.38 -0.65 1.34e-40 Prostate cancer; CRC cis rs1949733 1.000 rs3103072 chr4:8508431 C/T cg13073564 chr4:8508604 NA 0.49 7.19 0.37 4.44e-12 Response to antineoplastic agents; CRC cis rs611744 0.538 rs59930666 chr8:109262296 T/C cg21045802 chr8:109455806 TTC35 0.46 7.04 0.36 1.1e-11 Dupuytren's disease; CRC cis rs12477438 0.501 rs2516833 chr2:99777405 T/C cg26064155 chr2:99771622 LIPT1;TSGA10 0.77 13.13 0.59 5.79e-32 Chronic sinus infection; CRC cis rs7772486 0.875 rs854146 chr6:146341033 A/G cg23711669 chr6:146136114 FBXO30 0.69 11.86 0.55 3.01e-27 Lobe attachment (rater-scored or self-reported); CRC cis rs6840360 0.615 rs55932132 chr4:152463897 G/T cg09659197 chr4:152720779 NA 0.31 5.64 0.3 3.6e-8 Intelligence (multi-trait analysis); CRC cis rs2213920 0.516 rs2188042 chr9:118159740 C/T cg13918206 chr9:118159781 DEC1 -0.83 -7.51 -0.38 5.71e-13 Docetaxel-induced peripheral neuropathy in metastatic castrate-resistant prostate cancer; CRC cis rs8072100 0.748 rs9908016 chr17:45551361 G/A cg08085267 chr17:45401833 C17orf57 -0.62 -10.0 -0.48 9.83e-21 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs6502050 0.835 rs67682841 chr17:80117745 T/C cg11859384 chr17:80120422 CCDC57 -0.37 -5.9 -0.31 8.99e-9 Life satisfaction; CRC cis rs34375054 0.672 rs58416336 chr12:125606428 G/T cg02766259 chr12:125626809 AACS -0.39 -7.52 -0.38 5.28e-13 Post bronchodilator FEV1/FVC ratio; CRC cis rs875971 0.520 rs2420597 chr7:65915986 A/G cg11764359 chr7:65958608 NA 0.6 9.23 0.45 3.28e-18 Aortic root size; CRC cis rs2734839 0.964 rs1107162 chr11:113289037 A/G cg14159747 chr11:113255604 NA -0.46 -7.95 -0.4 2.99e-14 Information processing speed; CRC cis rs4654899 0.733 rs10916907 chr1:21261088 A/C cg02927042 chr1:21476669 EIF4G3 -0.38 -6.09 -0.32 3.21e-9 Superior frontal gyrus grey matter volume; CRC cis rs72945132 0.598 rs61887432 chr11:70239065 A/C cg14191688 chr11:70257035 CTTN 0.56 7.75 0.39 1.14e-13 Coronary artery disease; CRC cis rs2050392 0.767 rs1536833 chr10:30699265 C/T cg18806716 chr10:30721971 MAP3K8 0.69 10.08 0.49 5.14e-21 Inflammatory bowel disease; CRC cis rs17209837 0.607 rs117917293 chr7:87114824 G/C cg00919237 chr7:87102261 ABCB4 -0.51 -6.52 -0.34 2.64e-10 Gallbladder cancer; CRC cis rs2153535 0.601 rs4140585 chr6:8503298 T/A cg21535247 chr6:8435926 SLC35B3 0.48 7.36 0.38 1.49e-12 Motion sickness; CRC cis rs826838 0.967 rs1719856 chr12:39127201 C/T cg13010199 chr12:38710504 ALG10B -0.41 -5.84 -0.31 1.26e-8 Heart rate; CRC cis rs1003719 0.680 rs2154537 chr21:38502012 G/C cg10648535 chr21:38446584 PIGP;TTC3 -0.5 -6.91 -0.36 2.45e-11 Eye color traits; CRC trans rs2727020 0.729 rs4315497 chr11:49214499 G/A cg15704280 chr7:45808275 SEPT13 0.86 14.88 0.63 1.18e-38 Coronary artery disease; CRC cis rs2228479 0.702 rs17233868 chr16:89803629 C/T cg06656553 chr16:89960601 TCF25 -0.68 -5.67 -0.3 3.16e-8 Skin colour saturation; CRC cis rs4664293 0.625 rs10460300 chr2:160634721 C/T cg08347373 chr2:160653686 CD302 0.43 7.42 0.38 1.03e-12 Monocyte percentage of white cells; CRC cis rs10883723 0.773 rs715439 chr10:104257809 A/C cg22532475 chr10:104410764 TRIM8 -0.36 -6.67 -0.35 1.06e-10 Allergic disease (asthma, hay fever or eczema); CRC trans rs1814175 0.588 rs1794144 chr11:49918233 A/G cg15704280 chr7:45808275 SEPT13 -0.94 -16.69 -0.68 9.55e-46 Height; CRC cis rs2688608 0.620 rs11000767 chr10:75516626 G/T cg16540259 chr10:75572220 NDST2 0.39 6.18 0.32 1.89e-9 Inflammatory bowel disease; CRC cis rs7739232 0.920 rs74734238 chr6:53528444 T/A cg15658676 chr6:53530538 KLHL31 -0.76 -5.9 -0.31 8.9e-9 Hip circumference adjusted for BMI; CRC cis rs10946940 0.965 rs62401383 chr6:27564547 C/T cg21251018 chr6:28226885 NKAPL -0.41 -6.39 -0.33 5.78e-10 Systemic lupus erythematosus; CRC cis rs6728302 0.557 rs7600132 chr2:233248198 C/A cg14418609 chr2:233286870 NA -0.69 -5.86 -0.31 1.15e-8 Height; CRC cis rs8180040 0.620 rs56217494 chr3:47048452 T/G cg02527881 chr3:46936655 PTH1R 0.33 5.79 0.3 1.63e-8 Colorectal cancer; CRC cis rs1552244 0.935 rs7652190 chr3:10105150 G/A cg18598329 chr3:10140678 FANCD2;C3orf24 -0.86 -11.36 -0.53 1.9e-25 Alzheimer's disease; CRC cis rs910316 0.934 rs7141705 chr14:75655352 G/C cg11812906 chr14:75593930 NEK9 -0.51 -7.67 -0.39 1.92e-13 Height; CRC cis rs9868809 0.881 rs2310996 chr3:48671834 T/C cg00383909 chr3:49044727 WDR6 0.59 6.45 0.33 4.04e-10 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; CRC cis rs62244186 0.659 rs9835270 chr3:44553722 G/A cg10263370 chr3:44754102 ZNF502 -0.36 -5.98 -0.31 5.66e-9 Depressive symptoms; CRC cis rs7953508 0.619 rs11107114 chr12:93972927 G/A cg18151635 chr12:93972918 NA -0.79 -11.58 -0.54 3.01e-26 Pubertal anthropometrics; CRC trans rs208520 0.690 rs4710311 chr6:66823223 C/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.01 -14.33 -0.62 1.62e-36 Exhaled nitric oxide output; CRC cis rs7412746 0.611 rs2271076 chr1:150916657 C/T cg10589385 chr1:150898437 SETDB1 0.27 5.92 0.31 7.89e-9 Melanoma; CRC trans rs916888 0.773 rs199451 chr17:44801784 G/A cg22968622 chr17:43663579 NA 1.43 18.95 0.72 1.14e-54 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs1129187 0.755 rs28868299 chr6:42921221 T/G cg21280719 chr6:42927975 GNMT -0.48 -10.51 -0.5 1.82e-22 Alzheimer's disease in APOE e4+ carriers; CRC cis rs7113874 0.543 rs7935708 chr11:8478545 C/A cg02811074 chr11:8615871 STK33 -0.35 -6.05 -0.32 3.92e-9 Body mass index in physically active individuals;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs34779708 0.733 rs4391768 chr10:35547595 A/G cg03585969 chr10:35415529 CREM 0.52 6.79 0.35 5.37e-11 Inflammatory bowel disease;Crohn's disease; CRC cis rs7760949 0.963 rs7453814 chr6:13918291 C/G cg27413430 chr6:13925136 RNF182 0.32 5.66 0.3 3.22e-8 Mean corpuscular hemoglobin concentration; CRC trans rs7615952 0.866 rs13063119 chr3:125643847 G/A cg07211511 chr3:129823064 LOC729375 -1.13 -18.72 -0.72 9.26e-54 Blood pressure (smoking interaction); CRC cis rs7677751 0.806 rs4864861 chr4:55097685 C/T cg17187183 chr4:55093834 PDGFRA 0.52 7.53 0.38 4.99e-13 Corneal astigmatism; CRC cis rs873946 0.586 rs12251911 chr10:134570595 A/G cg18305652 chr10:134549665 INPP5A 0.54 7.41 0.38 1.05e-12 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CRC cis rs7932354 0.528 rs4752952 chr11:47082858 T/C cg19486271 chr11:47235900 DDB2 -0.49 -7.57 -0.39 3.87e-13 Bone mineral density (hip);Bone mineral density; CRC cis rs514406 0.929 rs515857 chr1:53336859 A/G cg25767906 chr1:53392781 SCP2 -0.43 -7.06 -0.36 9.82e-12 Monocyte count; CRC cis rs863345 0.604 rs6689657 chr1:158462509 C/T cg12129480 chr1:158549410 OR10X1 -0.3 -6.27 -0.33 1.14e-9 Pneumococcal bacteremia; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg25312474 chr6:142468512 VTA1 0.48 7.6 0.39 3.17e-13 Liver disease severity in Alagille syndrome; CRC cis rs76878669 0.538 rs73489638 chr11:66127639 C/T cg18002602 chr11:66138449 SLC29A2 -0.32 -6.79 -0.35 5.38e-11 Educational attainment (years of education); CRC cis rs62408225 1.000 rs17513415 chr6:90947867 C/T cg06866423 chr6:90926672 BACH2 0.49 7.94 0.4 3.12e-14 Eosinophil counts;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC cis rs12142240 0.738 rs10489769 chr1:46806703 A/G cg14993813 chr1:46806288 NSUN4 -0.5 -6.37 -0.33 6.42e-10 Menopause (age at onset); CRC cis rs4481887 0.573 rs6689894 chr1:248409579 C/T cg00666640 chr1:248458726 OR2T12 0.41 6.94 0.36 2.15e-11 Common traits (Other); CRC cis rs7811142 1.000 rs60257855 chr7:100026780 G/C cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.74 10.09 0.49 4.85e-21 Platelet count; CRC trans rs875971 0.660 rs2191268 chr7:66110224 C/T cg18726036 chr6:35543610 FKBP5 0.35 6.02 0.31 4.56e-9 Aortic root size; CRC cis rs6502050 0.731 rs11867299 chr17:80088675 C/A cg02741985 chr17:80059408 CCDC57 0.43 7.13 0.37 6.48e-12 Life satisfaction; CRC trans rs916888 0.821 rs199506 chr17:44859031 A/G cg10053473 chr17:62856997 LRRC37A3 0.72 8.49 0.42 6.95e-16 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs9341808 0.690 rs2505932 chr6:80839252 G/T cg08355045 chr6:80787529 NA 0.34 5.81 0.31 1.47e-8 Sitting height ratio; CRC cis rs12545109 0.800 rs1440747 chr8:57417924 G/T cg09654669 chr8:57350985 NA 0.38 5.61 0.3 4.27e-8 Obesity-related traits; CRC cis rs1448094 0.512 rs12305828 chr12:86249153 C/G cg25456477 chr12:86230367 RASSF9 0.34 5.99 0.31 5.54e-9 Major depressive disorder; CRC cis rs2842992 0.830 rs2758352 chr6:160122921 A/G cg11366901 chr6:160182831 ACAT2 0.91 12.25 0.56 1.14e-28 Age-related macular degeneration (geographic atrophy); CRC cis rs6499255 0.951 rs3169315 chr16:69720964 G/A cg00738113 chr16:70207722 CLEC18C -0.39 -6.17 -0.32 2.05e-9 IgE levels; CRC cis rs6684514 1.000 rs11264468 chr1:156274585 C/G cg16558208 chr1:156270281 VHLL 0.57 8.89 0.44 4.08e-17 Mean corpuscular hemoglobin concentration;Glycated hemoglobin levels; CRC cis rs765787 0.530 rs12440321 chr15:45529385 G/A cg24006582 chr15:45444508 DUOX1 0.56 8.17 0.41 6.53e-15 Uric acid levels; CRC cis rs6674176 0.628 rs3828146 chr1:44428715 C/T cg12908607 chr1:44402522 ARTN -0.53 -9.48 -0.46 5.19e-19 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Cognitive ability; CRC cis rs9393692 0.645 rs6939048 chr6:26327953 G/A cg00631329 chr6:26305371 NA -0.72 -12.95 -0.58 2.86e-31 Educational attainment; CRC cis rs6502050 0.871 rs8066137 chr17:80074316 T/C cg19223190 chr17:80058835 NA -0.41 -6.56 -0.34 2.05e-10 Life satisfaction; CRC cis rs990171 1.000 rs11677107 chr2:103057087 C/A cg03938978 chr2:103052716 IL18RAP 0.45 5.74 0.3 2.18e-8 Lymphocyte counts; CRC trans rs9929218 0.954 rs35794312 chr16:68827785 G/A cg04657470 chr2:198365150 HSPE1;HSPD1 -0.78 -11.18 -0.52 8.3e-25 Colorectal cancer; CRC cis rs709400 1.000 rs7150141 chr14:104129352 G/A cg24130564 chr14:104152367 KLC1 -0.45 -6.9 -0.36 2.76e-11 Body mass index; CRC cis rs782590 0.721 rs1084525 chr2:55929430 C/T cg18811423 chr2:55921094 PNPT1 0.82 14.7 0.63 5.77e-38 Metabolic syndrome; CRC cis rs4363385 0.747 rs1338180 chr1:152981404 A/G cg25856811 chr1:152973957 SPRR3 -0.25 -6.78 -0.35 5.6e-11 Inflammatory skin disease; CRC trans rs916888 0.610 rs199453 chr17:44800946 C/T cg22968622 chr17:43663579 NA 0.84 11.46 0.53 8.31e-26 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs10504229 0.679 rs7840100 chr8:58036662 T/G cg02725872 chr8:58115012 NA -0.35 -5.99 -0.31 5.5e-9 Developmental language disorder (linguistic errors); CRC cis rs5769707 0.967 rs5770585 chr22:50007874 G/A cg05373962 chr22:49881684 NA -0.4 -7.55 -0.38 4.42e-13 Monocyte count;Monocyte percentage of white cells; CRC cis rs4819052 0.851 rs2838845 chr21:46670812 A/G cg02159808 chr21:46707872 POFUT2;LOC642852 0.48 6.53 0.34 2.53e-10 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs11148252 0.553 rs9536219 chr13:53227301 C/T cg12458913 chr13:53173898 NA 0.76 13.77 0.6 2.16e-34 Lewy body disease; CRC cis rs9300255 0.602 rs1106240 chr12:123626982 C/T cg00376283 chr12:123451042 ABCB9 0.57 6.79 0.35 5.15e-11 Neutrophil percentage of white cells; CRC cis rs10493773 0.609 rs10873716 chr1:86178347 G/T cg23216685 chr1:86174607 ZNHIT6 -0.29 -6.77 -0.35 6.02e-11 Urate levels in overweight individuals; CRC cis rs9399135 0.967 rs6919862 chr6:135352443 C/A cg22676075 chr6:135203613 NA 0.41 6.39 0.33 5.63e-10 Red blood cell count; CRC cis rs9486719 1.000 rs3798295 chr6:97052164 C/T cg18709589 chr6:96969512 KIAA0776 -0.52 -5.8 -0.3 1.54e-8 Migraine;Coronary artery disease; CRC cis rs1129187 0.755 rs9471985 chr6:42941324 T/C cg09436375 chr6:42928200 GNMT -0.34 -6.31 -0.33 8.84e-10 Alzheimer's disease in APOE e4+ carriers; CRC cis rs561341 1.000 rs2470267 chr17:30274132 G/A cg00745463 chr17:30367425 LRRC37B -0.71 -8.33 -0.42 2.15e-15 Hip circumference adjusted for BMI; CRC cis rs2692947 0.711 rs56791141 chr2:96587496 C/T cg22654517 chr2:96458247 NA 0.31 5.67 0.3 3.16e-8 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; CRC cis rs9399135 0.967 rs7741626 chr6:135314182 C/T cg22676075 chr6:135203613 NA 0.41 6.38 0.33 6.03e-10 Red blood cell count; CRC cis rs72781680 0.821 rs17046004 chr2:24144873 A/G cg08917208 chr2:24149416 ATAD2B 0.55 6.71 0.35 8.52e-11 Lymphocyte counts; CRC trans rs11039798 0.623 rs584851 chr11:48416321 A/G cg15704280 chr7:45808275 SEPT13 -0.64 -6.27 -0.33 1.12e-9 Axial length; CRC cis rs947211 0.750 rs5014255 chr1:205753870 C/A cg07157834 chr1:205819609 PM20D1 0.42 5.77 0.3 1.87e-8 Parkinson's disease; CRC cis rs6938 0.534 rs12904897 chr15:75217686 A/G cg09165964 chr15:75287851 SCAMP5 0.57 9.02 0.45 1.6e-17 Breast cancer; CRC cis rs11148252 0.553 rs9536219 chr13:53227301 C/T cg00495681 chr13:53174319 NA 0.84 15.13 0.64 1.3e-39 Lewy body disease; CRC cis rs644799 1.000 rs627568 chr11:95569253 A/C cg03916912 chr11:95522834 CEP57;FAM76B 0.96 18.23 0.71 8.43e-52 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs9549367 0.712 rs2316443 chr13:113864837 G/A cg00898013 chr13:113819073 PROZ -0.41 -5.85 -0.31 1.18e-8 Platelet distribution width; CRC cis rs9611565 0.512 rs132784 chr22:42052363 G/A cg03806693 chr22:41940476 POLR3H 1.01 12.35 0.56 4.95e-29 Vitiligo; CRC cis rs4478858 0.746 rs6703593 chr1:31689284 A/C cg00250761 chr1:31883323 NA 0.32 5.96 0.31 6.38e-9 Alcohol dependence; CRC trans rs1656966 1.000 rs1656966 chr3:186466252 C/T cg21942256 chr3:156892528 NA 0.42 6.04 0.32 4.19e-9 Myopia (pathological); CRC cis rs11190604 1.000 rs2298074 chr10:102247526 G/C cg16342193 chr10:102329863 NA -0.39 -6.23 -0.32 1.43e-9 Palmitoleic acid (16:1n-7) levels; CRC cis rs3736485 0.844 rs8039073 chr15:51759906 T/C cg08986416 chr15:51914746 DMXL2 -0.46 -6.5 -0.34 2.95e-10 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg19826439 chr1:226297528 NA 0.46 7.55 0.38 4.3e-13 Liver disease severity in Alagille syndrome; CRC cis rs2999083 0.524 rs9827325 chr3:127736174 T/C cg13719885 chr3:127795394 NA -0.38 -5.8 -0.3 1.59e-8 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; CRC cis rs1050631 0.564 rs1789549 chr18:33722425 A/G cg25426722 chr18:33708991 SLC39A6;ELP2 0.37 5.68 0.3 2.96e-8 Esophageal squamous cell cancer (length of survival); CRC cis rs2806561 0.734 rs11578046 chr1:23425139 G/A cg12483005 chr1:23474871 LUZP1 0.47 6.58 0.34 1.87e-10 Height; CRC cis rs2067615 0.524 rs10861645 chr12:107071130 C/T cg13491945 chr12:107078410 RFX4 0.36 6.16 0.32 2.13e-9 Heart rate; CRC cis rs3750082 0.692 rs34737146 chr7:32935926 G/A cg05721444 chr7:32995514 FKBP9 0.51 6.53 0.34 2.49e-10 Glomerular filtration rate (creatinine); CRC cis rs7487075 0.637 rs4438106 chr12:46715528 G/T cg22049899 chr12:47219821 SLC38A4 0.34 6.54 0.34 2.31e-10 Itch intensity from mosquito bite; CRC cis rs1799949 1.000 rs8176265 chr17:41213996 C/T cg19454999 chr17:41278357 BRCA1;NBR2 0.53 8.2 0.41 5.63e-15 Menopause (age at onset); CRC cis rs4285028 0.948 rs1920291 chr3:121672440 C/T cg20356878 chr3:121714668 ILDR1 -0.48 -6.95 -0.36 1.93e-11 Multiple sclerosis; CRC cis rs4654899 1.000 rs12126133 chr1:21456537 T/C cg02927042 chr1:21476669 EIF4G3 -0.47 -7.58 -0.39 3.67e-13 Superior frontal gyrus grey matter volume; CRC cis rs4713118 0.513 rs1225591 chr6:28148752 G/A cg12172441 chr6:28176163 NA 0.55 7.48 0.38 6.69e-13 Parkinson's disease; CRC cis rs4547160 0.781 rs10877951 chr12:63485882 T/C cg26727693 chr12:63544175 AVPR1A -0.42 -7.68 -0.39 1.82e-13 Morning vs. evening chronotype; CRC cis rs2153535 0.580 rs915352 chr6:8442766 G/A cg21535247 chr6:8435926 SLC35B3 0.48 7.24 0.37 3.19e-12 Motion sickness; CRC cis rs10256972 0.616 rs4998392 chr7:1113344 A/C cg03923535 chr7:1197113 ZFAND2A 0.56 7.94 0.4 3.25e-14 Longevity;Endometriosis; CRC cis rs853679 0.517 rs9468292 chr6:28095355 G/A cg15845792 chr6:28175446 NA 1.01 13.54 0.6 1.59e-33 Depression; CRC cis rs1865760 0.613 rs9379801 chr6:25901711 T/C cg03264133 chr6:25882463 NA -0.49 -7.34 -0.38 1.67e-12 Height; CRC trans rs57221529 0.709 rs72707023 chr5:667620 G/A cg25482853 chr8:67687455 SGK3 1.25 14.29 0.62 2.3e-36 Lung disease severity in cystic fibrosis; CRC cis rs10751667 0.666 rs6597962 chr11:976351 C/T cg06064525 chr11:970664 AP2A2 -0.35 -7.01 -0.36 1.34e-11 Alzheimer's disease (late onset); CRC cis rs13256369 0.951 rs13260947 chr8:8565883 A/G cg17143192 chr8:8559678 CLDN23 0.51 6.7 0.35 8.79e-11 Obesity-related traits; CRC cis rs8177253 0.761 rs1830083 chr3:133508551 G/A cg08048268 chr3:133502702 NA -0.47 -9.01 -0.44 1.71e-17 Iron status biomarkers; CRC cis rs11677416 1.000 rs17561 chr2:113537223 C/A cg27083787 chr2:113543245 IL1A 0.47 6.63 0.34 1.42e-10 Response to antipsychotic treatment in schizophrenia (working memory); CRC cis rs7619833 0.564 rs6551182 chr3:27252491 T/A cg02860705 chr3:27208620 NA 0.37 5.82 0.31 1.42e-8 Breast cancer; CRC cis rs7659604 0.605 rs2071486 chr4:122740162 C/T cg20573242 chr4:122745356 CCNA2 0.59 9.12 0.45 7.47e-18 Type 2 diabetes; CRC cis rs2153535 0.580 rs2143355 chr6:8517856 T/A cg07606381 chr6:8435919 SLC35B3 0.66 10.74 0.51 2.78e-23 Motion sickness; CRC cis rs11146838 1 rs11146838 chr10:39149977 A/T cg03665457 chr10:38645376 HSD17B7P2 -0.45 -6.36 -0.33 6.91e-10 Breast cancer; CRC cis rs6662572 0.542 rs72677553 chr1:46592278 C/T cg03123370 chr1:45965343 CCDC163P;MMACHC 0.49 6.4 0.33 5.26e-10 Blood protein levels; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg04747728 chr16:31725053 ZNF720 0.43 6.89 0.36 2.81e-11 Liver disease severity in Alagille syndrome; CRC cis rs896854 0.654 rs2011566 chr8:95971921 G/A cg09323728 chr8:95962352 TP53INP1 -0.42 -7.0 -0.36 1.47e-11 Type 2 diabetes; CRC trans rs16934284 0.706 rs11790102 chr9:119846424 T/C cg16808373 chr11:122850140 BSX -0.4 -5.99 -0.31 5.51e-9 Obesity-related traits; CRC cis rs4243830 0.737 rs6692747 chr1:6610049 C/T cg05709478 chr1:6581295 PLEKHG5 0.64 6.39 0.33 5.52e-10 Body mass index; CRC cis rs881375 0.967 rs2416806 chr9:123690292 G/C cg09419670 chr9:123605666 PSMD5;LOC253039 0.57 8.39 0.42 1.45e-15 Rheumatoid arthritis; CRC cis rs6500602 0.627 rs863501 chr16:4588394 G/C cg06139259 chr16:4526053 HMOX2;NMRAL1 -0.46 -6.14 -0.32 2.41e-9 Schizophrenia; CRC cis rs9322193 0.923 rs62441279 chr6:150042330 G/A cg00933542 chr6:150070202 PCMT1 0.31 6.42 0.33 4.7e-10 Lung cancer; CRC cis rs875971 1.000 rs7783613 chr7:65805261 C/T cg18876405 chr7:65276391 NA -0.52 -8.84 -0.44 6.02e-17 Aortic root size; CRC trans rs61931739 0.534 rs1486886 chr12:34043619 C/T cg26384229 chr12:38710491 ALG10B 0.51 6.88 0.35 3.1e-11 Morning vs. evening chronotype; CRC cis rs7618915 0.524 rs35249778 chr3:52661640 G/C cg10802521 chr3:52805072 NEK4 -0.58 -8.98 -0.44 2.1e-17 Bipolar disorder; CRC cis rs62064224 0.560 rs12162135 chr17:30805795 A/C cg12855166 chr17:30846586 MYO1D -0.38 -6.25 -0.33 1.24e-9 Schizophrenia; CRC cis rs7666738 0.830 rs1813251 chr4:98921170 A/G cg05340658 chr4:99064831 C4orf37 0.6 9.23 0.45 3.31e-18 Colonoscopy-negative controls vs population controls; CRC cis rs1862618 0.671 rs252897 chr5:56223000 G/A cg20203395 chr5:56204925 C5orf35 -0.57 -7.69 -0.39 1.77e-13 Initial pursuit acceleration; CRC trans rs2303319 0.504 rs12467625 chr2:162603387 C/A cg11326919 chr17:43324904 LOC100133991 -0.64 -5.97 -0.31 5.99e-9 Cognitive function; CRC trans rs4942242 1.000 rs4942242 chr13:44217064 A/G cg26741380 chr15:41871084 TYRO3 0.4 5.98 0.31 5.98e-9 Response to tocilizumab in rheumatoid arthritis; CRC cis rs763014 0.966 rs4984904 chr16:680809 C/G cg09263875 chr16:632152 PIGQ 0.79 12.53 0.57 1e-29 Height; CRC cis rs847577 0.609 rs11765552 chr7:97822115 T/A cg24562669 chr7:97807699 LMTK2 0.79 17.64 0.7 1.72e-49 Breast cancer; CRC cis rs28386778 0.863 rs3760254 chr17:61851751 T/G cg11494091 chr17:61959527 GH2 0.59 10.1 0.49 4.39e-21 Prudent dietary pattern; CRC cis rs9916302 0.904 rs7223331 chr17:37482930 A/G cg15445000 chr17:37608096 MED1 -0.43 -9.45 -0.46 6.71e-19 Glomerular filtration rate (creatinine); CRC cis rs7666738 0.606 rs4637413 chr4:99088151 A/G cg05340658 chr4:99064831 C4orf37 0.49 7.21 0.37 3.95e-12 Colonoscopy-negative controls vs population controls; CRC cis rs853679 0.517 rs868987 chr6:28110148 A/G cg23161317 chr6:28129485 ZNF389 -0.48 -5.94 -0.31 7.25e-9 Depression; CRC cis rs10464366 0.544 rs2280667 chr7:39172228 A/C cg15212455 chr7:39170539 POU6F2 0.47 6.15 0.32 2.25e-9 IgG glycosylation; CRC cis rs896854 0.715 rs12548874 chr8:95935164 A/C cg23172400 chr8:95962367 TP53INP1 0.47 7.78 0.39 9.69e-14 Type 2 diabetes; CRC cis rs9326248 0.559 rs476399 chr11:116733728 T/C cg01368799 chr11:117014884 PAFAH1B2 0.41 6.5 0.34 3.06e-10 Blood protein levels; CRC cis rs6921919 0.848 rs56131013 chr6:28320677 G/A cg21251018 chr6:28226885 NKAPL 0.39 5.66 0.3 3.31e-8 Autism spectrum disorder or schizophrenia; CRC cis rs853679 0.517 rs9357061 chr6:28051772 A/G cg15845792 chr6:28175446 NA 0.97 13.08 0.58 8.89e-32 Depression; CRC cis rs2288073 0.801 rs2384008 chr2:24373150 A/G cg06627628 chr2:24431161 ITSN2 -0.55 -7.98 -0.4 2.5e-14 Venous thromboembolism (SNP x SNP interaction); CRC cis rs2276314 0.857 rs4799408 chr18:33588982 C/T cg05985134 chr18:33552581 C18orf21 -0.44 -6.38 -0.33 6.03e-10 Endometriosis;Drug-induced torsades de pointes; CRC cis rs2658782 0.901 rs11604909 chr11:93218355 C/G cg15737290 chr11:93063684 CCDC67 0.53 7.44 0.38 8.87e-13 Pulmonary function decline; CRC cis rs734999 0.550 rs2985855 chr1:2531372 A/C cg18854424 chr1:2615690 NA -0.42 -8.07 -0.41 1.3e-14 Ulcerative colitis; CRC cis rs2932538 0.845 rs6682678 chr1:113206920 A/G cg22162597 chr1:113214053 CAPZA1 -0.68 -9.61 -0.47 2.01e-19 Systolic blood pressure;Diastolic blood pressure;Hypertension;Blood pressure; CRC cis rs7020830 0.858 rs13293465 chr9:37127678 C/T cg14294708 chr9:37120828 ZCCHC7 1.22 28.25 0.84 5.77e-90 Schizophrenia; CRC cis rs8180040 0.701 rs11917474 chr3:47010491 G/A cg02527881 chr3:46936655 PTH1R -0.43 -8.05 -0.41 1.56e-14 Colorectal cancer; CRC cis rs1448094 0.511 rs10506923 chr12:86152595 C/T cg06740227 chr12:86229804 RASSF9 -0.38 -5.78 -0.3 1.74e-8 Major depressive disorder; CRC cis rs7811142 0.779 rs111312383 chr7:99905325 C/T cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.13 15.38 0.65 1.39e-40 Platelet count; CRC cis rs10479542 0.784 rs6601050 chr5:178986261 C/G cg21226059 chr5:178986404 RUFY1 -0.4 -7.28 -0.37 2.48e-12 Lung cancer; CRC cis rs9911578 1.000 rs2531732 chr17:56548420 T/A cg12560992 chr17:57184187 TRIM37 -0.9 -16.49 -0.67 5.75e-45 Intelligence (multi-trait analysis); CRC cis rs4713118 0.866 rs9468217 chr6:27726467 G/A cg06470822 chr6:28175283 NA 0.78 9.62 0.47 1.86e-19 Parkinson's disease; CRC cis rs6840360 0.571 rs28608620 chr4:152504791 C/T cg09659197 chr4:152720779 NA 0.3 5.68 0.3 2.93e-8 Intelligence (multi-trait analysis); CRC trans rs1997103 1.000 rs6951294 chr7:55400835 C/T cg20935933 chr6:143382018 AIG1 0.52 6.72 0.35 7.8e-11 QRS interval (sulfonylurea treatment interaction); CRC cis rs12325245 0.536 rs35832551 chr16:58591444 G/T cg02549819 chr16:58548995 SETD6 1.16 7.58 0.39 3.52e-13 Schizophrenia; CRC cis rs375066 0.623 rs7254659 chr19:44350689 T/C cg19542119 chr19:44331823 ZNF283 0.4 5.61 0.3 4.24e-8 Breast cancer; CRC cis rs7208859 0.623 rs9890558 chr17:29110355 T/C cg13385521 chr17:29058706 SUZ12P 0.73 8.4 0.42 1.39e-15 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs2479724 1.000 rs1536703 chr6:41852755 C/T cg17623882 chr6:41773611 USP49 -0.52 -8.6 -0.43 3.41e-16 Menarche (age at onset); CRC cis rs9322193 0.923 rs1112729 chr6:150087627 C/A cg07701084 chr6:150067640 NUP43 0.46 6.49 0.34 3.1e-10 Lung cancer; CRC cis rs4654899 0.758 rs6658679 chr1:21376451 T/C cg11157611 chr1:21499906 EIF4G3 0.32 5.61 0.3 4.21e-8 Superior frontal gyrus grey matter volume; CRC cis rs9311474 0.508 rs1570 chr3:52586682 T/A cg10802521 chr3:52805072 NEK4 -0.56 -8.91 -0.44 3.55e-17 Electroencephalogram traits; CRC cis rs713477 1.000 rs12887846 chr14:55911139 T/C cg13175173 chr14:55914753 NA -0.52 -9.85 -0.48 3.19e-20 Pediatric bone mineral content (femoral neck); CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg11576217 chr1:204381098 PPP1R15B 0.55 7.14 0.37 5.9e-12 Thyroid stimulating hormone; CRC trans rs916888 0.610 rs199529 chr17:44837217 A/C cg22968622 chr17:43663579 NA 1.16 14.05 0.61 1.92e-35 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs898097 0.841 rs8180 chr17:80901036 C/G cg03160526 chr17:80928410 B3GNTL1 0.47 6.9 0.36 2.62e-11 Breast cancer; CRC cis rs3087591 0.708 rs8067440 chr17:29708155 A/T cg24425628 chr17:29625626 OMG;NF1 0.71 12.88 0.58 5e-31 Hip circumference; CRC cis rs807669 0.903 rs1780642 chr22:19170604 T/C cg02655711 chr22:19163373 SLC25A1 0.99 21.34 0.76 4.66e-64 Metabolite levels; CRC trans rs916888 0.738 rs199515 chr17:44856641 C/G cg07870213 chr5:140052090 DND1 -0.84 -10.1 -0.49 4.55e-21 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs7666738 0.830 rs6854902 chr4:99033416 T/G cg05340658 chr4:99064831 C4orf37 0.61 9.42 0.46 8.23e-19 Colonoscopy-negative controls vs population controls; CRC cis rs898097 0.756 rs56249965 chr17:80806603 C/G cg15664640 chr17:80829946 TBCD -0.69 -11.19 -0.53 7.63e-25 Breast cancer; CRC cis rs7208859 0.623 rs1054397 chr17:29110196 T/C cg13385521 chr17:29058706 SUZ12P 0.74 8.41 0.42 1.27e-15 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg09403165 chr15:90118814 C15orf42 0.45 6.75 0.35 6.5e-11 Intelligence (multi-trait analysis); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg19105961 chr17:4046223 CYB5D2;ZZEF1 0.45 7.43 0.38 9.71e-13 Liver disease severity in Alagille syndrome; CRC cis rs7949030 0.596 rs71490394 chr11:62370155 G/A cg11742103 chr11:62369870 EML3;MTA2 0.62 11.67 0.54 1.42e-26 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; CRC cis rs4494114 0.967 rs9438977 chr1:39354958 A/G cg25970120 chr1:39325951 RRAGC -0.45 -6.34 -0.33 7.75e-10 Blood protein levels; CRC cis rs9399135 1.000 rs4896130 chr6:135355118 C/T cg24558204 chr6:135376177 HBS1L 0.48 7.42 0.38 1e-12 Red blood cell count; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg26500707 chr16:50100227 HEATR3 0.45 6.37 0.33 6.52e-10 Anxiety disorder; CRC cis rs9435341 0.965 rs9435441 chr1:107603330 C/G cg09367891 chr1:107599246 PRMT6 -0.64 -10.12 -0.49 3.78e-21 Facial morphology (factor 21, depth of nasal alae); CRC cis rs951366 0.617 rs823074 chr1:205774839 T/C cg06877462 chr1:205807181 PM20D1 0.38 5.9 0.31 8.85e-9 Menarche (age at onset); CRC cis rs9291683 0.935 rs1860910 chr4:10275470 T/G cg00071950 chr4:10020882 SLC2A9 0.51 9.47 0.46 5.52e-19 Bone mineral density; CRC cis rs881375 0.678 rs1014530 chr9:123685092 T/C cg09419670 chr9:123605666 PSMD5;LOC253039 0.44 6.84 0.35 3.89e-11 Rheumatoid arthritis; CRC cis rs282587 0.569 rs282595 chr13:113379930 A/G cg04656015 chr13:113407548 ATP11A -0.64 -7.92 -0.4 3.67e-14 Glycated hemoglobin levels; CRC cis rs3858704 0.517 rs7297186 chr12:111778178 C/T cg10833066 chr12:111807467 FAM109A -0.61 -8.97 -0.44 2.31e-17 Idiopathic osteonecrosis of the femoral head; CRC trans rs2727020 0.554 rs2866490 chr11:49425463 A/G cg11707556 chr5:10655725 ANKRD33B -0.47 -7.45 -0.38 8.39e-13 Coronary artery disease; CRC cis rs514406 0.929 rs555741 chr1:53318851 T/G cg08859206 chr1:53392774 SCP2 -0.44 -6.9 -0.36 2.66e-11 Monocyte count; CRC trans rs2235573 0.527 rs139865 chr22:38353932 C/G cg19894588 chr14:64061835 NA 0.47 6.92 0.36 2.31e-11 Glioblastoma;Glioma; CRC cis rs2019137 0.936 rs12620738 chr2:113963739 C/T cg07772999 chr2:113993052 PAX8;LOC440839;LOC654433 -0.45 -6.42 -0.33 4.89e-10 Lymphocyte counts; CRC cis rs4073416 0.542 rs7143318 chr14:65940689 G/A cg03016385 chr14:66212404 NA -0.42 -5.83 -0.31 1.31e-8 N-glycan levels; CRC cis rs12922317 0.556 rs11648938 chr16:12094149 C/T cg02368508 chr16:12060182 TNFRSF17 0.46 7.75 0.39 1.14e-13 Schizophrenia; CRC trans rs1814175 0.654 rs1164676 chr11:49324868 T/C cg21153622 chr11:89784906 NA 0.41 6.33 0.33 8.25e-10 Height; CRC trans rs35110281 0.811 rs7275705 chr21:45056453 G/C cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.53 9.06 0.45 1.23e-17 Mean corpuscular volume; CRC cis rs4780401 0.728 rs8057398 chr16:11780629 G/T cg01061890 chr16:11836724 TXNDC11 -0.48 -6.77 -0.35 5.97e-11 Rheumatoid arthritis; CRC cis rs6500602 0.826 rs11076830 chr16:4460049 A/G cg14951292 chr16:4525986 HMOX2;NMRAL1 0.66 8.43 0.42 1.13e-15 Schizophrenia; CRC cis rs10504229 0.683 rs67048677 chr8:58140023 C/G cg02725872 chr8:58115012 NA -0.64 -11.55 -0.54 3.85e-26 Developmental language disorder (linguistic errors); CRC cis rs11148252 0.967 rs4286007 chr13:53022518 A/G cg00495681 chr13:53174319 NA 0.6 9.35 0.46 1.36e-18 Lewy body disease; CRC cis rs2067615 0.524 rs10778498 chr12:107063340 C/A cg15890332 chr12:107067104 RFX4 0.31 5.61 0.3 4.2e-8 Heart rate; CRC cis rs10791097 0.967 rs10750450 chr11:130719061 G/T cg12179176 chr11:130786555 SNX19 0.57 8.86 0.44 5.26e-17 Autism spectrum disorder or schizophrenia;Schizophrenia; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg01172785 chr16:50092553 NA -0.39 -6.45 -0.34 4.02e-10 Liver disease severity in Alagille syndrome; CRC cis rs12580194 0.593 rs7976828 chr12:55726450 A/T cg23425280 chr12:56401806 NA 0.48 5.93 0.31 7.76e-9 Cancer; CRC cis rs1552244 0.554 rs6762594 chr3:9995516 G/A cg18598329 chr3:10140678 FANCD2;C3orf24 -0.52 -7.53 -0.38 4.79e-13 Alzheimer's disease; CRC trans rs13046373 0.905 rs4816372 chr21:32077414 A/T cg02400139 chr5:145890299 TCERG1 -0.39 -6.19 -0.32 1.83e-9 HDL cholesterol; CRC cis rs9311676 0.656 rs7642652 chr3:58373667 C/T cg06643156 chr3:58380774 PXK 0.41 6.33 0.33 7.82e-10 Systemic lupus erythematosus; CRC cis rs9614461 0.702 rs2294202 chr22:45738327 A/T cg01808030 chr22:45809952 RIBC2;SMC1B 0.49 5.81 0.31 1.48e-8 Tonsillectomy; CRC cis rs11711311 1.000 rs34475696 chr3:113458293 T/C cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.51 -6.84 -0.35 3.88e-11 IgG glycosylation; CRC cis rs4665809 1.000 rs6709595 chr2:26259885 A/G cg04944784 chr2:26401820 FAM59B -0.58 -7.52 -0.38 5.39e-13 Gut microbiome composition (summer); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg08235883 chr12:122238836 LOC338799 0.47 6.48 0.34 3.34e-10 Response to antipsychotic treatment; CRC cis rs13256369 0.951 rs13270852 chr8:8566853 A/G cg06636001 chr8:8085503 FLJ10661 0.48 5.99 0.31 5.4e-9 Obesity-related traits; CRC cis rs9322193 0.923 rs3924871 chr6:149983216 G/A cg13206674 chr6:150067644 NUP43 0.65 9.76 0.47 6.08e-20 Lung cancer; CRC cis rs2303759 0.881 rs10412811 chr19:49884495 G/A cg22590775 chr19:49891494 CCDC155 0.66 9.3 0.46 1.96e-18 Multiple sclerosis; CRC cis rs11650494 0.808 rs76366926 chr17:47396628 T/C cg08112188 chr17:47440006 ZNF652 1.26 11.54 0.54 4.31e-26 Prostate cancer; CRC cis rs7715806 0.500 rs17649266 chr5:75001252 C/T cg19683494 chr5:74908142 NA -0.57 -6.44 -0.33 4.19e-10 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs67311347 1.000 rs34762643 chr3:40475433 C/T cg09455208 chr3:40491958 NA 0.43 8.72 0.43 1.36e-16 Renal cell carcinoma; CRC cis rs990171 0.955 rs4851008 chr2:103026611 G/C cg03938978 chr2:103052716 IL18RAP 0.46 5.82 0.31 1.4e-8 Lymphocyte counts; CRC cis rs9858542 0.953 rs9821311 chr3:49543656 C/T cg03060546 chr3:49711283 APEH -0.47 -6.6 -0.34 1.63e-10 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs7173743 0.784 rs11072811 chr15:79132330 G/T cg15571903 chr15:79123663 NA -0.32 -5.97 -0.31 6.08e-9 Coronary artery disease; CRC trans rs11088226 0.846 rs2154500 chr21:33926391 T/C cg09050820 chr6:167586206 TCP10L2 0.68 8.61 0.43 3.1e-16 Gastritis; CRC cis rs2075671 0.903 rs4727459 chr7:100276821 T/C cg20848291 chr7:100343083 ZAN -0.67 -10.1 -0.49 4.64e-21 Other erythrocyte phenotypes; CRC cis rs79349575 0.679 rs9894239 chr17:46997959 C/T cg22482690 chr17:47019901 SNF8 -0.42 -6.81 -0.35 4.65e-11 Type 2 diabetes; CRC cis rs6461049 0.800 rs2398706 chr7:2156338 A/T cg21782813 chr7:2030301 MAD1L1 0.47 8.36 0.42 1.75e-15 Schizophrenia; CRC cis rs7666738 0.753 rs13137152 chr4:98938044 A/T cg05340658 chr4:99064831 C4orf37 0.61 9.5 0.46 4.59e-19 Colonoscopy-negative controls vs population controls; CRC cis rs453301 0.522 rs2929309 chr8:9083771 C/A cg08975724 chr8:8085496 FLJ10661 -0.41 -6.24 -0.33 1.32e-9 Joint mobility (Beighton score); CRC cis rs9381040 0.610 rs9357345 chr6:41025118 G/C cg04346459 chr6:41068666 NFYA;LOC221442 -0.41 -6.14 -0.32 2.43e-9 Alzheimer's disease (late onset); CRC trans rs2235573 0.653 rs6519095 chr22:38431917 G/A cg19894588 chr14:64061835 NA 0.41 5.99 0.31 5.52e-9 Glioblastoma;Glioma; CRC cis rs79349575 0.783 rs9912829 chr17:46982749 G/C cg22482690 chr17:47019901 SNF8 0.49 8.2 0.41 5.33e-15 Type 2 diabetes; CRC cis rs17666538 0.710 rs7834337 chr8:655828 A/G cg26554054 chr8:600488 NA 0.58 6.07 0.32 3.49e-9 IgG glycosylation; CRC cis rs6952808 0.895 rs12669518 chr7:1921429 G/C cg21782813 chr7:2030301 MAD1L1 0.45 8.09 0.41 1.16e-14 Bipolar disorder and schizophrenia; CRC cis rs6558174 0.965 rs7831119 chr8:22489678 C/T cg03733263 chr8:22462867 KIAA1967 -0.52 -6.96 -0.36 1.89e-11 Breast cancer; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg25448636 chr17:17140084 FLCN 0.48 7.07 0.36 9.12e-12 Intelligence (multi-trait analysis); CRC cis rs2336384 1.000 rs4846083 chr1:12045555 G/T cg13216073 chr1:12042593 MFN2 0.51 7.44 0.38 8.71e-13 Platelet count; CRC cis rs8180040 0.932 rs62246474 chr3:47398130 C/T cg27129171 chr3:47204927 SETD2 -0.65 -10.34 -0.5 6.98e-22 Colorectal cancer; CRC cis rs10256972 0.706 rs12701970 chr7:1121958 T/C cg18402987 chr7:1209562 NA 0.44 6.3 0.33 9.7e-10 Longevity;Endometriosis; CRC cis rs6951245 1.000 rs2363286 chr7:1091625 A/G cg21664854 chr7:1097933 C7orf50;GPR146 0.67 7.67 0.39 1.92e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs7618915 0.547 rs34610878 chr3:52759169 G/C cg18099408 chr3:52552593 STAB1 -0.44 -7.24 -0.37 3.28e-12 Bipolar disorder; CRC trans rs6544773 0.550 rs2673272 chr2:45050208 C/G cg10208897 chr5:178548229 ADAMTS2 0.35 6.12 0.32 2.63e-9 Mosquito bite size; CRC cis rs12701220 0.689 rs6973645 chr7:1112246 C/T cg00990874 chr7:1149470 C7orf50 -0.5 -5.84 -0.31 1.24e-8 Bronchopulmonary dysplasia; CRC cis rs2075184 1 rs2075184 chr2:103080592 T/C cg03938978 chr2:103052716 IL18RAP 0.46 5.88 0.31 1e-8 Pediatric autoimmune diseases; CRC trans rs7615952 0.932 rs13325495 chr3:125637416 T/G cg00769240 chr8:12517080 NA -0.56 -6.12 -0.32 2.63e-9 Blood pressure (smoking interaction); CRC cis rs789859 1.000 rs789859 chr3:194405888 G/T cg21106136 chr3:194405973 FAM43A -0.44 -6.47 -0.34 3.65e-10 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; CRC cis rs9372498 0.505 rs4416700 chr6:118975461 G/C cg22561889 chr6:118971681 C6orf204 0.51 6.26 0.33 1.23e-9 Diastolic blood pressure; CRC cis rs6570726 0.902 rs373321 chr6:145854150 T/A cg23711669 chr6:146136114 FBXO30 0.7 12.47 0.57 1.65e-29 Lobe attachment (rater-scored or self-reported); CRC cis rs6748734 0.625 rs4675871 chr2:241823849 G/A cg16358738 chr2:241808595 AGXT -0.4 -6.92 -0.36 2.32e-11 Urinary metabolites; CRC cis rs3749237 0.964 rs34522271 chr3:49808517 A/G cg03060546 chr3:49711283 APEH 0.51 7.7 0.39 1.61e-13 Resting heart rate; CRC cis rs10540 1.000 rs61876323 chr11:462855 G/A cg19913688 chr11:428466 ANO9 -0.72 -7.58 -0.39 3.58e-13 Body mass index; CRC cis rs921968 0.619 rs1554623 chr2:219606177 C/T cg02176678 chr2:219576539 TTLL4 -0.43 -6.71 -0.35 8.33e-11 Mean corpuscular hemoglobin concentration; CRC cis rs6424115 0.733 rs2502996 chr1:24199041 T/C cg15997130 chr1:24165203 NA 0.72 10.56 0.5 1.22e-22 Immature fraction of reticulocytes; CRC cis rs875971 0.929 rs12673810 chr7:65923853 T/A cg18876405 chr7:65276391 NA 0.52 8.85 0.44 5.32e-17 Aortic root size; CRC cis rs875971 0.571 rs160641 chr7:65577346 G/A cg03233332 chr7:66118400 NA 0.45 6.36 0.33 6.69e-10 Aortic root size; CRC cis rs561341 0.769 rs8074383 chr17:30178793 C/T cg12193833 chr17:30244370 NA 0.6 6.74 0.35 7.01e-11 Hip circumference adjusted for BMI; CRC cis rs9992667 0.955 rs922334 chr4:38616758 C/T cg19726192 chr4:38663646 FLJ13197 -0.52 -6.7 -0.35 9.05e-11 Eosinophil percentage of granulocytes; CRC cis rs4664293 0.967 rs10202187 chr2:160427646 C/T cg08347373 chr2:160653686 CD302 -0.46 -7.43 -0.38 9.56e-13 Monocyte percentage of white cells; CRC cis rs3768617 0.706 rs10797801 chr1:182971965 G/T ch.1.3577855R chr1:183094577 LAMC1 0.66 10.09 0.49 5.04e-21 Fuchs's corneal dystrophy; CRC cis rs2797160 0.967 rs4897151 chr6:125993202 T/G cg05901451 chr6:126070800 HEY2 -0.38 -5.83 -0.31 1.33e-8 Endometrial cancer; CRC cis rs6500602 0.727 rs4786509 chr16:4568769 C/G cg08645402 chr16:4508243 NA -0.64 -11.46 -0.53 8.1e-26 Schizophrenia; CRC cis rs2067615 0.579 rs7975576 chr12:107132501 A/G cg13491945 chr12:107078410 RFX4 0.35 5.94 0.31 7.32e-9 Heart rate; CRC cis rs853679 0.517 rs9380052 chr6:28064623 A/G cg02683197 chr6:28174875 NA 0.83 10.17 0.49 2.7e-21 Depression; CRC trans rs1005277 0.579 rs1548255 chr10:38417193 T/C cg11292332 chr7:45801988 SEPT13 -0.35 -6.27 -0.33 1.14e-9 Extrinsic epigenetic age acceleration; CRC cis rs35146811 0.844 rs4424195 chr7:99642745 A/G cg13334819 chr7:99746414 C7orf59 -0.49 -6.93 -0.36 2.18e-11 Coronary artery disease; CRC cis rs1633360 1 rs1633360 chr12:58108052 C/T cg15848620 chr12:58087721 OS9 -0.53 -7.53 -0.38 4.86e-13 Rheumatoid arthritis; CRC cis rs6582630 0.594 rs7308707 chr12:38450428 G/C cg13010199 chr12:38710504 ALG10B -0.43 -5.97 -0.31 6.2e-9 Drug-induced liver injury (flucloxacillin); CRC cis rs4332037 0.707 rs10268797 chr7:1873756 C/G cg23422044 chr7:1970798 MAD1L1 0.5 6.41 0.33 4.94e-10 Bipolar disorder; CRC cis rs6429082 0.818 rs291341 chr1:235663174 G/T cg26050004 chr1:235667680 B3GALNT2 0.58 7.91 0.4 3.89e-14 Adiposity; CRC cis rs2677744 0.626 rs2001216 chr15:91498130 T/C cg23684204 chr15:91497937 RCCD1 0.47 7.2 0.37 4.04e-12 Attention deficit hyperactivity disorder; CRC cis rs9768139 0.935 rs10155946 chr7:158122116 C/T cg25566285 chr7:158114605 PTPRN2 -0.57 -9.57 -0.47 2.65e-19 Calcium levels; CRC cis rs8060686 0.565 rs55857142 chr16:68236741 A/T cg26727032 chr16:67993705 SLC12A4 -0.53 -6.24 -0.33 1.34e-9 HDL cholesterol;Metabolic syndrome; CRC cis rs826838 0.904 rs11612004 chr12:39204282 G/A cg26384229 chr12:38710491 ALG10B 0.69 9.33 0.46 1.61e-18 Heart rate; CRC cis rs7917772 0.599 rs2863717 chr10:104519829 A/G cg11453585 chr10:104263688 ACTR1A;SUFU -0.69 -10.29 -0.49 1.06e-21 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC cis rs7208859 0.623 rs9911173 chr17:29154750 C/T cg01831904 chr17:28903510 LRRC37B2 -0.62 -6.5 -0.34 2.9e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs4474465 0.790 rs4544031 chr11:78265403 G/C cg27205649 chr11:78285834 NARS2 0.48 6.07 0.32 3.56e-9 Alzheimer's disease (survival time); CRC cis rs908922 0.676 rs4845788 chr1:152519496 T/C cg23254163 chr1:152506842 NA 0.49 9.71 0.47 9.19e-20 Hair morphology; CRC cis rs877282 0.842 rs35117541 chr10:764683 C/T cg06581033 chr10:766294 NA -0.53 -5.88 -0.31 1.01e-8 Uric acid levels; CRC cis rs1448094 0.512 rs11832503 chr12:86240797 A/G cg00310523 chr12:86230176 RASSF9 0.34 5.79 0.3 1.67e-8 Major depressive disorder; CRC trans rs12744310 0.887 rs17362424 chr1:41794403 A/C cg19175123 chr10:103411746 FBXW4 -0.45 -6.08 -0.32 3.24e-9 Cognitive ability (multi-trait analysis);Intelligence;Cognitive ability; CRC cis rs713587 0.967 rs713586 chr2:25158008 A/G cg04586622 chr2:25135609 ADCY3 -0.44 -7.84 -0.4 6.53e-14 Body mass index in non-asthmatics; CRC cis rs7208859 0.623 rs7217984 chr17:29092766 G/A cg13385521 chr17:29058706 SUZ12P 0.73 8.33 0.42 2.14e-15 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs9926296 0.605 rs6500453 chr16:89858657 C/G cg03388025 chr16:89894329 SPIRE2 0.43 8.56 0.43 4.25e-16 Vitiligo; CRC trans rs2797160 1.000 rs1832938 chr6:125988964 G/C cg05039488 chr6:79577232 IRAK1BP1 -0.49 -7.43 -0.38 9.71e-13 Endometrial cancer; CRC cis rs60871478 0.838 rs7789321 chr7:800977 A/G cg13844804 chr7:814759 HEATR2 0.71 8.24 0.41 4.04e-15 Cerebrospinal P-tau181p levels; CRC cis rs425277 1.000 rs262657 chr1:2088577 G/A cg24578937 chr1:2090814 PRKCZ 0.66 11.76 0.54 6.73e-27 Height; CRC trans rs877282 0.945 rs71489301 chr10:770191 A/G cg22713356 chr15:30763199 NA 1.16 14.97 0.64 5.46e-39 Uric acid levels; CRC trans rs2303319 0.504 rs62189043 chr2:162608466 A/T cg12500891 chr11:57225987 NA -0.65 -6.06 -0.32 3.77e-9 Cognitive function; CRC cis rs2456568 0.548 rs1607402 chr11:93660732 T/G cg26875233 chr11:93583750 C11orf90 -0.36 -6.91 -0.36 2.46e-11 Response to serotonin reuptake inhibitors in major depressive disorder; CRC cis rs2302729 0.578 rs11062299 chr12:2771738 T/C cg19945202 chr12:2788847 CACNA1C -0.43 -6.93 -0.36 2.28e-11 Sleep quality; CRC cis rs9916302 0.706 rs12937013 chr17:37665571 G/A cg07936489 chr17:37558343 FBXL20 -0.93 -11.91 -0.55 1.88e-27 Glomerular filtration rate (creatinine); CRC cis rs743757 1.000 rs2236957 chr3:50440426 A/G cg08207895 chr3:50388901 TUSC4;CYB561D2 0.44 6.52 0.34 2.64e-10 Diastolic blood pressure; CRC cis rs17270561 0.636 rs6456698 chr6:25741664 A/C cg16482183 chr6:26056742 HIST1H1C 0.83 10.69 0.51 4.46e-23 Iron status biomarkers; CRC cis rs11098499 0.874 rs12502503 chr4:120116255 C/T cg09307838 chr4:120376055 NA 0.61 8.95 0.44 2.69e-17 Corneal astigmatism; CRC cis rs713477 0.967 rs6573028 chr14:55913397 C/T cg21836586 chr14:55907198 TBPL2 0.3 5.6 0.3 4.51e-8 Pediatric bone mineral content (femoral neck); CRC cis rs10097731 0.901 rs10464891 chr8:82042900 C/A cg25230327 chr8:82042993 NA -0.93 -13.69 -0.6 4.32e-34 Serum total protein level; CRC cis rs9491140 1.000 rs9491142 chr6:124693017 G/A cg22366943 chr6:124882293 NKAIN2 0.36 5.94 0.31 7.32e-9 Neuroticism; CRC cis rs2404602 0.716 rs12902174 chr15:76863540 T/C cg03037974 chr15:76606532 NA 0.66 11.44 0.53 9.38e-26 Blood metabolite levels; CRC cis rs4713118 0.869 rs6930992 chr6:27712120 A/C cg25164649 chr6:28176230 NA 0.58 8.19 0.41 5.97e-15 Parkinson's disease; CRC cis rs7072216 0.555 rs2296432 chr10:100184063 C/G cg26618903 chr10:100175079 PYROXD2 -0.49 -7.34 -0.38 1.67e-12 Metabolite levels; CRC cis rs13096480 0.583 rs17598137 chr3:49891362 G/T cg08802409 chr3:50649298 CISH 0.4 5.93 0.31 7.69e-9 Intelligence (multi-trait analysis); CRC cis rs10504229 0.638 rs7826839 chr8:58132075 G/T cg02725872 chr8:58115012 NA -0.64 -11.55 -0.54 3.85e-26 Developmental language disorder (linguistic errors); CRC cis rs8014204 0.773 rs2241275 chr14:75251440 C/T cg03030879 chr14:75389066 RPS6KL1 0.5 7.87 0.4 5.18e-14 Caffeine consumption; CRC cis rs7659604 0.702 rs58649165 chr4:122693752 C/A cg06713675 chr4:122721982 EXOSC9 -0.51 -8.29 -0.42 2.88e-15 Type 2 diabetes; CRC cis rs9682041 0.877 rs6804688 chr3:170071191 T/G cg11886554 chr3:170076028 SKIL 0.59 6.74 0.35 7.26e-11 Glomerular filtration rate in non diabetics (creatinine);Glomerular filtration rate (creatinine); CRC cis rs2249694 1.000 rs4512750 chr10:135358664 A/G cg16964102 chr10:135390573 NA -0.41 -6.76 -0.35 6.44e-11 Obesity-related traits; CRC cis rs763121 0.853 rs9607566 chr22:39075434 C/G cg06022373 chr22:39101656 GTPBP1 0.79 12.36 0.56 4.51e-29 Menopause (age at onset); CRC cis rs1552244 0.816 rs13059144 chr3:10010197 A/C cg16606324 chr3:10149918 C3orf24 0.62 8.05 0.41 1.58e-14 Alzheimer's disease; CRC cis rs10504229 0.683 rs67492041 chr8:58140077 G/A cg05313129 chr8:58192883 C8orf71 -0.43 -6.11 -0.32 2.74e-9 Developmental language disorder (linguistic errors); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg11504634 chr17:40714731 COASY 0.42 6.04 0.32 4.17e-9 Response to antipsychotic treatment; CRC cis rs2019137 0.868 rs6755639 chr2:113981810 A/G cg21482265 chr2:113992762 PAX8;LOC440839;LOC654433 0.46 6.53 0.34 2.46e-10 Lymphocyte counts; CRC cis rs11711311 0.955 rs7617313 chr3:113391740 T/G cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.53 -6.94 -0.36 2.15e-11 IgG glycosylation; CRC cis rs7727544 0.735 rs272881 chr5:131669264 G/A cg24060327 chr5:131705240 SLC22A5 -0.38 -6.23 -0.32 1.41e-9 Blood metabolite levels; CRC cis rs629535 0.862 rs2178955 chr8:70045303 C/T cg26132723 chr8:70041827 NA 0.35 5.72 0.3 2.41e-8 Dupuytren's disease; CRC cis rs1799949 1.000 rs35956818 chr17:41422985 T/C cg01879757 chr17:41196368 BRCA1 -0.44 -6.71 -0.35 8.37e-11 Menopause (age at onset); CRC cis rs7665939 1.000 rs72727637 chr4:190106678 G/T cg09826759 chr4:190284978 NA -0.74 -6.17 -0.32 2.01e-9 Amyotrophic lateral sclerosis; CRC cis rs873946 0.586 rs12782567 chr10:134576709 C/G cg26818010 chr10:134567672 INPP5A 0.72 9.3 0.46 2.06e-18 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CRC cis rs6534441 0.727 rs55697817 chr4:125451962 G/A cg21609808 chr4:125404261 NA 0.44 6.28 0.33 1.08e-9 Major depressive disorder; CRC cis rs2227564 0.620 rs3911887 chr10:75548026 A/G cg00564723 chr10:75632066 CAMK2G -0.31 -7.45 -0.38 8.41e-13 Crohn's disease;Inflammatory bowel disease; CRC cis rs12744221 1 rs12744221 chr1:145645606 C/T cg11743829 chr1:145714124 CD160 -0.4 -6.09 -0.32 3.23e-9 Epilepsy (remission after treatment); CRC cis rs720844 1.000 rs4972285 chr2:149340684 C/T cg09247360 chr2:149335327 NA 0.54 7.05 0.36 1.09e-11 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs9942416 0.660 rs2047059 chr5:75008193 T/C cg19683494 chr5:74908142 NA 0.42 5.77 0.3 1.82e-8 Age-related disease endophenotypes; CRC cis rs9828933 0.752 rs12633353 chr3:63970280 T/C cg16258503 chr3:63850278 ATXN7;THOC7 -0.71 -5.98 -0.31 5.86e-9 Type 2 diabetes; CRC cis rs7412746 0.611 rs2280627 chr1:150935872 A/G cg17724175 chr1:150552817 MCL1 0.41 6.3 0.33 9.8e-10 Melanoma; CRC cis rs7301826 0.627 rs1077317 chr12:131314977 C/T cg11011512 chr12:131303247 STX2 0.39 5.85 0.31 1.18e-8 Plasma plasminogen activator levels; CRC trans rs7395662 0.500 rs7951327 chr11:48925359 C/T cg21153622 chr11:89784906 NA -0.53 -8.81 -0.44 7.35e-17 HDL cholesterol; CRC cis rs9322193 0.926 rs9689036 chr6:150101699 T/C cg13206674 chr6:150067644 NUP43 0.54 7.76 0.39 1.11e-13 Lung cancer; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg27457169 chr17:38804285 SMARCE1 0.44 6.25 0.33 1.26e-9 Anxiety disorder; CRC cis rs172166 0.516 rs1150670 chr6:28130559 A/G cg06470822 chr6:28175283 NA 0.66 10.08 0.49 5.48e-21 Cardiac Troponin-T levels; CRC trans rs11148252 0.514 rs2296347 chr13:52728423 A/C cg18335740 chr13:41363409 SLC25A15 -0.5 -7.27 -0.37 2.69e-12 Lewy body disease; CRC trans rs2243480 0.901 rs35823062 chr7:65965821 A/G cg10756647 chr7:56101905 PSPH 0.76 7.85 0.4 5.78e-14 Diabetic kidney disease; CRC cis rs6582630 0.638 rs12231073 chr12:38526901 T/G cg26384229 chr12:38710491 ALG10B -0.54 -7.8 -0.39 8.34e-14 Drug-induced liver injury (flucloxacillin); CRC cis rs10504229 0.953 rs6991035 chr8:58183374 C/T cg22535103 chr8:58192502 C8orf71 -0.82 -12.27 -0.56 9.63e-29 Developmental language disorder (linguistic errors); CRC cis rs6540559 1.000 rs2073485 chr1:209962794 G/A cg25204440 chr1:209979598 IRF6 0.52 6.77 0.35 5.93e-11 Cleft lip with or without cleft palate; CRC cis rs6543140 0.964 rs6543138 chr2:103066132 G/A cg03938978 chr2:103052716 IL18RAP 0.42 6.71 0.35 8.38e-11 Blood protein levels; CRC trans rs3942852 0.868 rs7118226 chr11:48106267 T/G cg15704280 chr7:45808275 SEPT13 -0.58 -7.11 -0.36 7.43e-12 Acute lymphoblastic leukemia (childhood); CRC cis rs1799949 1.000 rs1973646 chr17:41310495 T/C cg25072359 chr17:41440525 NA 0.44 6.4 0.33 5.29e-10 Menopause (age at onset); CRC cis rs2243480 1.000 rs402418 chr7:65509469 G/A cg18252515 chr7:66147081 NA -1.19 -13.16 -0.59 4.5e-32 Diabetic kidney disease; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg06400595 chr12:56551642 MYL6B;MYL6 0.5 7.8 0.4 8.48e-14 Liver disease severity in Alagille syndrome; CRC cis rs7737355 0.853 rs6873582 chr5:130892741 A/G cg06307176 chr5:131281290 NA 0.44 6.46 0.34 3.7e-10 Life satisfaction; CRC cis rs2456568 0.802 rs10765638 chr11:93636171 A/T cg26875233 chr11:93583750 C11orf90 -0.32 -6.27 -0.33 1.14e-9 Response to serotonin reuptake inhibitors in major depressive disorder; CRC cis rs9549367 0.789 rs34989271 chr13:113894766 G/A cg18105134 chr13:113819100 PROZ -0.72 -10.38 -0.5 5.21e-22 Platelet distribution width; CRC cis rs6674970 1.000 rs6676190 chr1:151079317 C/T cg03258749 chr1:151040405 MLLT11 -0.47 -7.23 -0.37 3.32e-12 Childhood ear infection; CRC cis rs8077889 0.917 rs9901676 chr17:41911818 T/C cg25876840 chr17:41920477 NA 0.51 7.64 0.39 2.33e-13 Triglycerides; CRC cis rs6503525 0.591 rs8080734 chr17:38103285 G/A cg24910161 chr17:38119198 GSDMA -0.44 -7.82 -0.4 7.02e-14 Asthma; CRC cis rs4925386 0.840 rs6143034 chr20:60920545 T/C cg15193198 chr20:60906057 LAMA5 -0.41 -6.24 -0.33 1.33e-9 Colorectal cancer;Colorectal cancer (SNP x SNP interaction); CRC cis rs10788264 0.652 rs9633732 chr10:124056473 G/T cg09507567 chr10:124027408 NA 0.32 7.05 0.36 1.08e-11 Total body bone mineral density; CRC cis rs9926296 0.585 rs8058009 chr16:89856439 G/A cg02609749 chr16:89786786 C16orf7;ZNF276 0.42 5.77 0.3 1.86e-8 Vitiligo; CRC cis rs7216064 1.000 rs62084214 chr17:65843325 C/G cg12091567 chr17:66097778 LOC651250 -0.68 -7.87 -0.4 5.31e-14 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CRC cis rs2991971 0.967 rs512026 chr1:46009946 G/T cg03123370 chr1:45965343 CCDC163P;MMACHC -0.38 -5.72 -0.3 2.43e-8 High light scatter reticulocyte count; CRC cis rs1568889 0.838 rs10767708 chr11:28294847 A/G cg06544937 chr11:28130018 METT5D1;KIF18A 0.91 15.34 0.65 1.93e-40 Bipolar disorder; CRC cis rs9911578 0.967 rs9894274 chr17:56977919 G/A cg05425664 chr17:57184151 TRIM37 -0.49 -7.67 -0.39 1.99e-13 Intelligence (multi-trait analysis); CRC cis rs9911578 1.000 rs8071280 chr17:57010225 T/C cg05425664 chr17:57184151 TRIM37 -0.5 -7.85 -0.4 6.06e-14 Intelligence (multi-trait analysis); CRC cis rs910316 1.000 rs175426 chr14:75624134 C/T cg11812906 chr14:75593930 NEK9 -0.59 -9.13 -0.45 7.28e-18 Height; CRC cis rs4148883 0.504 rs4585310 chr4:100120233 T/C cg13256891 chr4:100009986 ADH5 -0.42 -6.47 -0.34 3.54e-10 Alcohol dependence; CRC cis rs62229266 0.839 rs11088335 chr21:37470335 C/T cg08632701 chr21:37451849 NA -0.37 -5.78 -0.3 1.69e-8 Mitral valve prolapse; CRC cis rs8072100 1.000 rs7210738 chr17:45757598 G/A cg08085267 chr17:45401833 C17orf57 0.67 10.84 0.51 1.29e-23 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs4076764 0.801 rs12046142 chr1:163375247 G/A cg24596788 chr1:163392923 NA -0.64 -10.48 -0.5 2.36e-22 Motion sickness; CRC cis rs11764590 0.715 rs55810445 chr7:2103739 C/T cg21155852 chr7:2048760 MAD1L1 -0.46 -5.99 -0.31 5.35e-9 Neuroticism; CRC cis rs4631830 0.900 rs7075009 chr10:51544143 T/G cg20129853 chr10:51489980 NA -0.35 -5.7 -0.3 2.6e-8 Prostate-specific antigen levels; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg11893236 chr16:68345102 PRMT7;SLC7A6OS 0.43 5.99 0.31 5.46e-9 Response to antipsychotic treatment; CRC cis rs1005277 0.579 rs2472178 chr10:38384750 T/C cg25517755 chr10:38738941 LOC399744 -0.41 -6.09 -0.32 3.13e-9 Extrinsic epigenetic age acceleration; CRC cis rs7772486 0.875 rs969694 chr6:146394655 A/G cg23711669 chr6:146136114 FBXO30 0.62 10.56 0.5 1.23e-22 Lobe attachment (rater-scored or self-reported); CRC cis rs1044826 0.642 rs1580642 chr3:139132203 A/C cg00490450 chr3:139108681 COPB2 -0.47 -7.08 -0.36 8.86e-12 Obesity-related traits; CRC cis rs7666738 0.830 rs1426663 chr4:98990092 T/G cg05340658 chr4:99064831 C4orf37 0.61 9.55 0.47 3.06e-19 Colonoscopy-negative controls vs population controls; CRC cis rs8040855 0.599 rs6496800 chr15:85728286 G/C cg04831495 chr15:85060580 GOLGA6L5 0.36 5.68 0.3 2.96e-8 Bulimia nervosa; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg16501701 chr17:73852221 WBP2 0.43 6.05 0.32 3.89e-9 Response to antipsychotic treatment; CRC cis rs539096 0.501 rs713191 chr1:44314553 A/G cg12908607 chr1:44402522 ARTN -0.53 -9.56 -0.47 2.92e-19 Intelligence (multi-trait analysis); CRC cis rs3789045 0.560 rs3747634 chr1:204411063 C/T cg17419461 chr1:204415978 PIK3C2B 0.81 10.79 0.51 1.93e-23 Educational attainment (college completion); CRC cis rs12893668 0.638 rs11851616 chr14:104065600 G/A cg24130564 chr14:104152367 KLC1 -0.42 -5.65 -0.3 3.43e-8 Reticulocyte count; CRC cis rs2882667 0.654 rs825760 chr5:138139974 G/T cg09476006 chr5:138032270 NA -0.53 -8.86 -0.44 5.18e-17 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs1862618 0.802 rs194058 chr5:56188977 G/A cg24531977 chr5:56204891 C5orf35 -0.86 -11.11 -0.52 1.51e-24 Initial pursuit acceleration; CRC trans rs7615952 0.641 rs6805074 chr3:125772274 T/A cg07211511 chr3:129823064 LOC729375 -0.72 -9.7 -0.47 9.79e-20 Blood pressure (smoking interaction); CRC cis rs765787 0.530 rs2554453 chr15:45522107 A/G cg24006582 chr15:45444508 DUOX1 -0.56 -8.55 -0.43 4.67e-16 Uric acid levels; CRC cis rs1862618 0.853 rs2113079 chr5:56157951 A/G cg18230493 chr5:56204884 C5orf35 -0.71 -9.22 -0.45 3.78e-18 Initial pursuit acceleration; CRC cis rs6840360 0.615 rs6831810 chr4:152461995 A/G cg09659197 chr4:152720779 NA 0.31 5.66 0.3 3.25e-8 Intelligence (multi-trait analysis); CRC trans rs11098499 0.863 rs10034450 chr4:120455649 A/G cg25214090 chr10:38739885 LOC399744 0.65 10.07 0.49 5.96e-21 Corneal astigmatism; CRC cis rs736408 0.608 rs6445534 chr3:52743384 G/A cg11645453 chr3:52864694 ITIH4 0.36 6.51 0.34 2.86e-10 Bipolar disorder; CRC cis rs8044868 0.530 rs9932951 chr16:72075341 A/G cg06172871 chr16:72088244 HP 0.44 6.26 0.33 1.2e-9 Body mass index (change over time) in cancer or chronic obstructive pulmonary disease;Body mass index (change over time) in cancer; CRC cis rs7772486 0.686 rs2179323 chr6:145982786 T/G cg13319975 chr6:146136371 FBXO30 0.43 6.33 0.33 8.17e-10 Lobe attachment (rater-scored or self-reported); CRC cis rs9399135 0.967 rs6929661 chr6:135328792 G/A cg22676075 chr6:135203613 NA 0.42 6.49 0.34 3.24e-10 Red blood cell count; CRC cis rs7914558 1.000 rs7081075 chr10:104929191 C/T cg15744005 chr10:104629667 AS3MT -0.34 -7.32 -0.37 1.97e-12 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs832540 0.931 rs832529 chr5:56229288 C/T cg18230493 chr5:56204884 C5orf35 -0.39 -5.85 -0.31 1.22e-8 Coronary artery disease; CRC cis rs7677751 0.806 rs7678144 chr4:55102425 T/C cg13615338 chr4:55094005 PDGFRA 0.39 5.66 0.3 3.29e-8 Corneal astigmatism; CRC cis rs11190604 0.767 rs4559620 chr10:102199935 C/T cg07080220 chr10:102295463 HIF1AN 0.47 5.65 0.3 3.42e-8 Palmitoleic acid (16:1n-7) levels; CRC cis rs10911363 0.592 rs2275675 chr1:183439483 C/T cg09173681 chr1:183549694 NCF2 -0.74 -10.36 -0.5 6.15e-22 Systemic lupus erythematosus; CRC cis rs2289583 0.642 rs67624860 chr15:75391557 A/G cg14664628 chr15:75095509 CSK 0.44 6.19 0.32 1.83e-9 Systemic lupus erythematosus; CRC cis rs12142240 0.698 rs17413694 chr1:46818416 A/C cg14993813 chr1:46806288 NSUN4 -0.48 -6.15 -0.32 2.24e-9 Menopause (age at onset); CRC cis rs3741404 0.895 rs2429455 chr11:63995302 C/G cg19465662 chr11:63993652 NUDT22;TRPT1 0.82 14.09 0.61 1.29e-35 Platelet count; CRC cis rs9811920 0.809 rs923472 chr3:99758029 A/T cg07805332 chr3:99536008 MIR548G;C3orf26 0.41 6.37 0.33 6.21e-10 Axial length; CRC cis rs995000 0.931 rs11207979 chr1:62982994 G/A cg19896129 chr1:63156450 NA 0.42 6.39 0.33 5.8e-10 Triglyceride levels; CRC cis rs1448094 0.511 rs7967183 chr12:86216845 T/G cg19622623 chr12:86230825 RASSF9 -0.39 -6.33 -0.33 7.89e-10 Major depressive disorder; CRC cis rs2243480 0.901 rs3813708 chr7:65305632 C/A cg25985355 chr7:65971099 NA -0.51 -5.79 -0.3 1.64e-8 Diabetic kidney disease; CRC cis rs4713118 0.869 rs6456802 chr6:27698355 A/G cg25164649 chr6:28176230 NA 0.58 8.19 0.41 5.97e-15 Parkinson's disease; CRC cis rs155076 1.000 rs261431 chr13:21865738 A/G cg25811766 chr13:21894605 NA 0.53 5.69 0.3 2.88e-8 White matter hyperintensity burden; CRC cis rs35110281 0.548 rs7276316 chr21:45029333 A/T cg01579765 chr21:45077557 HSF2BP -0.38 -7.11 -0.37 7.06e-12 Mean corpuscular volume; CRC cis rs7772486 0.597 rs7746618 chr6:146281367 T/C cg23711669 chr6:146136114 FBXO30 -0.65 -9.61 -0.47 1.92e-19 Lobe attachment (rater-scored or self-reported); CRC cis rs2742417 0.603 rs2742374 chr3:45784082 T/C cg04837898 chr3:45731254 SACM1L -0.47 -7.57 -0.39 3.81e-13 Response to anti-depressant treatment in major depressive disorder; CRC cis rs601338 1 rs601338 chr19:49206674 G/A cg21064579 chr19:49206444 FUT2 0.51 9.11 0.45 8.09e-18 Number of common colds;Blood metabolite levels;Blood metabolite ratios; CRC cis rs12701220 0.725 rs13242971 chr7:1055515 C/T cg00990874 chr7:1149470 C7orf50 -0.58 -6.87 -0.35 3.19e-11 Bronchopulmonary dysplasia; CRC cis rs77861329 0.748 rs352152 chr3:52210700 A/C cg08692210 chr3:52188851 WDR51A -0.5 -5.89 -0.31 9.65e-9 Macrophage inflammatory protein 1b levels; CRC trans rs11098499 0.913 rs10010696 chr4:120164303 T/C cg25214090 chr10:38739885 LOC399744 0.52 8.0 0.4 2.15e-14 Corneal astigmatism; CRC cis rs72781680 0.898 rs56315094 chr2:23941952 T/C cg08917208 chr2:24149416 ATAD2B 0.88 8.5 0.42 6.69e-16 Lymphocyte counts; CRC cis rs9486719 0.857 rs4839833 chr6:96882069 T/C cg06623918 chr6:96969491 KIAA0776 0.83 11.29 0.53 3.31e-25 Migraine;Coronary artery disease; CRC cis rs9640161 0.711 rs3800781 chr7:150027324 T/A cg12556325 chr7:150026731 C7orf29;LRRC61 -0.46 -7.04 -0.36 1.13e-11 Blood protein levels;Circulating chemerin levels; CRC cis rs910316 1.000 rs7156105 chr14:75541954 C/A cg11812906 chr14:75593930 NEK9 0.66 10.91 0.52 7.54e-24 Height; CRC cis rs6545883 0.560 rs11677775 chr2:61503110 T/C cg10580144 chr2:61372316 C2orf74 -0.35 -7.78 -0.39 9.61e-14 Tuberculosis; CRC cis rs929354 0.742 rs3808317 chr7:156944460 A/G cg16102536 chr7:156981717 UBE3C 0.4 6.69 0.35 9.57e-11 Body mass index; CRC cis rs2235642 0.750 rs763152 chr16:1658056 T/C cg09065629 chr16:1709722 CRAMP1L 0.36 5.62 0.3 4.09e-8 Coronary artery disease; CRC cis rs4654899 1.000 rs6663452 chr1:21423154 T/C cg02927042 chr1:21476669 EIF4G3 -0.51 -8.12 -0.41 9.48e-15 Superior frontal gyrus grey matter volume; CRC cis rs2303745 0.589 rs10401700 chr19:17397700 A/C cg27101125 chr19:17392770 ANKLE1 -0.32 -5.78 -0.3 1.74e-8 Systemic lupus erythematosus; CRC cis rs4689388 0.856 rs4308430 chr4:6294095 A/G cg25554036 chr4:6271136 WFS1 0.53 8.71 0.43 1.54e-16 Type 2 diabetes and other traits;Type 2 diabetes; CRC cis rs2115630 0.645 rs1107179 chr15:85198362 A/C cg17507749 chr15:85114479 UBE2QP1 0.41 6.13 0.32 2.57e-9 P wave terminal force; CRC cis rs4547160 0.821 rs949824 chr12:63482910 C/T cg26727693 chr12:63544175 AVPR1A -0.41 -7.45 -0.38 8.23e-13 Morning vs. evening chronotype; CRC trans rs208520 0.661 rs1776361 chr6:66822270 G/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.08 -15.09 -0.64 1.81e-39 Exhaled nitric oxide output; CRC cis rs9549260 0.755 rs2721044 chr13:41162225 C/T cg21288729 chr13:41239152 FOXO1 0.39 5.98 0.31 5.7e-9 Red blood cell count; CRC cis rs600626 0.588 rs72997616 chr11:75474195 C/A cg24262691 chr11:75473276 NA 0.54 7.47 0.38 7.26e-13 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CRC cis rs2050392 0.858 rs306583 chr10:30710057 C/T cg18806716 chr10:30721971 MAP3K8 0.5 7.62 0.39 2.67e-13 Inflammatory bowel disease; CRC cis rs11785693 0.862 rs11774099 chr8:4988218 C/T cg26367366 chr8:4980734 NA 0.81 9.93 0.48 1.65e-20 Neuroticism (multi-trait analysis);Neuroticism; CRC cis rs6692729 0.966 rs8383 chr1:227083550 C/T cg18027831 chr1:227083489 PSEN2 0.36 5.92 0.31 8.02e-9 Electrodermal activity; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg04297258 chr16:88772664 RNF166;CTU2 0.5 6.58 0.34 1.87e-10 Thyroid stimulating hormone; CRC cis rs977987 0.815 rs11861810 chr16:75461829 A/G cg03315344 chr16:75512273 CHST6 0.55 9.25 0.45 3.01e-18 Dupuytren's disease; CRC cis rs2153535 0.546 rs9378559 chr6:8539058 A/T cg21535247 chr6:8435926 SLC35B3 0.51 7.72 0.39 1.44e-13 Motion sickness; CRC cis rs3741404 0.609 rs669913 chr11:63869879 A/G cg18225595 chr11:63971243 STIP1 0.41 6.61 0.34 1.55e-10 Platelet count; CRC cis rs172166 0.637 rs1225592 chr6:28150242 G/A cg25164649 chr6:28176230 NA 0.69 10.25 0.49 1.39e-21 Cardiac Troponin-T levels; CRC cis rs7107174 0.792 rs12291726 chr11:78088210 A/G cg02023728 chr11:77925099 USP35 0.49 7.45 0.38 8.28e-13 Testicular germ cell tumor; CRC cis rs4713118 0.587 rs61471148 chr6:28037032 T/A cg15786705 chr6:28176104 NA 0.71 9.2 0.45 4.11e-18 Parkinson's disease; CRC cis rs1577917 0.793 rs9362245 chr6:86496320 G/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.45 -6.04 -0.32 4.23e-9 Response to antipsychotic treatment; CRC cis rs6951245 0.872 rs112309216 chr7:1100296 A/T cg20603222 chr7:1096387 C7orf50;GPR146 -0.72 -8.66 -0.43 2.19e-16 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs9326248 0.559 rs484646 chr11:116732856 A/G cg10398005 chr11:117014888 PAFAH1B2 -0.39 -5.84 -0.31 1.25e-8 Blood protein levels; CRC trans rs7647973 0.626 rs6809879 chr3:49834571 A/G cg21659725 chr3:3221576 CRBN 0.61 6.88 0.35 2.99e-11 Menarche (age at onset); CRC cis rs7772486 0.875 rs9322048 chr6:146400439 A/G cg23711669 chr6:146136114 FBXO30 0.58 9.88 0.48 2.56e-20 Lobe attachment (rater-scored or self-reported); CRC cis rs7666738 0.830 rs9992391 chr4:98916052 G/A cg05340658 chr4:99064831 C4orf37 0.56 8.42 0.42 1.21e-15 Colonoscopy-negative controls vs population controls; CRC cis rs9902453 0.845 rs58575982 chr17:28221776 A/T cg26525008 chr17:28256777 EFCAB5;SSH2 0.57 8.62 0.43 2.93e-16 Coffee consumption (cups per day); CRC cis rs13118159 0.573 rs4974618 chr4:1373663 C/T cg02018176 chr4:1364513 KIAA1530 0.68 11.7 0.54 1.08e-26 Longevity; CRC cis rs344364 0.511 rs56077812 chr16:1948870 T/G cg00046913 chr16:1877150 HAGH;FAHD1 -0.58 -6.06 -0.32 3.66e-9 Glomerular filtration rate in chronic kidney disease; CRC cis rs7618915 0.570 rs11130312 chr3:52675055 A/C cg10802521 chr3:52805072 NEK4 -0.58 -9.0 -0.44 1.8e-17 Bipolar disorder; CRC cis rs7618915 0.547 rs2336542 chr3:52710636 A/G cg10802521 chr3:52805072 NEK4 -0.59 -9.02 -0.45 1.55e-17 Bipolar disorder; CRC cis rs7618501 0.699 rs6446187 chr3:49907111 C/A cg24308560 chr3:49941425 MST1R -0.5 -7.93 -0.4 3.38e-14 Intelligence (multi-trait analysis); CRC trans rs4332037 0.510 rs58673065 chr7:1885600 A/G cg11693508 chr17:37793320 STARD3 0.54 7.7 0.39 1.64e-13 Bipolar disorder; CRC trans rs7395662 0.591 rs10838972 chr11:48611400 A/G cg03929089 chr4:120376271 NA -0.46 -6.52 -0.34 2.68e-10 HDL cholesterol; CRC cis rs17601876 0.814 rs8039089 chr15:51561328 T/G cg19946085 chr15:51559439 CYP19A1 -0.34 -7.05 -0.36 1.08e-11 Estrone/androstenedione ratio in resected early stage-receptor positive breast cancer; CRC cis rs9896933 0.667 rs2253131 chr17:80696547 T/A cg15664640 chr17:80829946 TBCD -0.56 -6.29 -0.33 1.04e-9 Bone mineral accretion in asthma (oral corticosteroid dose interaction); CRC cis rs4805272 0.626 rs12610050 chr19:29331324 A/T cg12756686 chr19:29218302 NA 0.45 6.34 0.33 7.57e-10 Plasma omega-3 polyunsaturated fatty acid levels (docosahexaenoic acid); CRC cis rs1387259 0.929 rs2634666 chr12:48663670 G/T cg24011408 chr12:48396354 COL2A1 0.45 6.32 0.33 8.27e-10 Obstructive sleep apnea trait (apnea hypopnea index); CRC trans rs10506458 1.000 rs1009539 chr12:63414655 A/G cg03429785 chr15:59498649 MYO1E;LDHAL6B 1.39 19.61 0.73 2.96e-57 Hemostatic factors and hematological phenotypes; CRC cis rs2179367 0.959 rs9373592 chr6:149733255 A/T cg11245181 chr6:149772854 ZC3H12D -0.42 -6.21 -0.32 1.58e-9 Dupuytren's disease; CRC cis rs6499255 0.951 rs7198242 chr16:69648495 C/T cg15192750 chr16:69999425 NA -0.61 -8.17 -0.41 6.58e-15 IgE levels; CRC cis rs1005277 0.541 rs2263163 chr10:38389887 G/A cg25517755 chr10:38738941 LOC399744 -0.44 -6.38 -0.33 5.95e-10 Extrinsic epigenetic age acceleration; CRC cis rs1552244 1.000 rs9879080 chr3:10084224 C/T cg00166722 chr3:10149974 C3orf24 0.67 9.23 0.45 3.37e-18 Alzheimer's disease; CRC cis rs9487051 1.000 rs9487051 chr6:109617079 A/G cg01475377 chr6:109611718 NA -0.44 -7.93 -0.4 3.41e-14 Reticulocyte fraction of red cells; CRC cis rs17376456 0.877 rs10062711 chr5:93348659 G/A cg25358565 chr5:93447407 FAM172A 1.07 10.72 0.51 3.41e-23 Diabetic retinopathy; CRC cis rs6570726 0.764 rs4896821 chr6:145896181 G/A cg13319975 chr6:146136371 FBXO30 -0.39 -5.77 -0.3 1.85e-8 Lobe attachment (rater-scored or self-reported); CRC cis rs992157 0.796 rs55680399 chr2:219160621 T/C cg04880052 chr2:219191631 PNKD 0.41 6.73 0.35 7.55e-11 Colorectal cancer; CRC cis rs6499129 0.558 rs13334205 chr16:67581883 A/G cg26727032 chr16:67993705 SLC12A4 -0.6 -7.82 -0.4 7.16e-14 Waist-to-hip ratio adjusted for body mass index; CRC cis rs1401999 1.000 rs4148571 chr3:183720576 A/C cg05044414 chr3:183734942 ABCC5 0.47 8.12 0.41 9.66e-15 Anterior chamber depth; CRC cis rs6686643 1.000 rs6686643 chr1:165616588 T/C cg19407955 chr1:165599744 MGST3 -0.44 -5.63 -0.3 3.9e-8 Total ventricular volume; CRC cis rs9522267 0.535 rs9522304 chr13:112237316 C/T cg10483660 chr13:112241077 NA -0.48 -9.1 -0.45 9.18e-18 Hepatitis; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg10622236 chr15:42120082 JMJD7;JMJD7-PLA2G4B 0.47 6.88 0.35 3.02e-11 Intelligence (multi-trait analysis); CRC cis rs861020 0.630 rs628445 chr1:210004953 C/T cg09163369 chr1:210001066 C1orf107 0.4 5.75 0.3 2.08e-8 Orofacial clefts; CRC cis rs1865760 0.516 rs9393684 chr6:26075531 G/C cg17691542 chr6:26056736 HIST1H1C 0.53 8.05 0.41 1.48e-14 Height; CRC cis rs7246657 0.943 rs4417644 chr19:37852472 A/G cg23950597 chr19:37808831 NA -0.54 -6.5 -0.34 2.93e-10 Coronary artery calcification; CRC trans rs6479874 0.831 rs2245627 chr10:52745666 G/A cg15483030 chr1:5935144 NPHP4 -0.71 -6.34 -0.33 7.64e-10 Migraine; CRC cis rs364477 0.904 rs420062 chr9:957950 C/A cg13952963 chr9:998547 NA 0.55 5.89 0.31 9.79e-9 Major depressive disorder; CRC trans rs561341 1.000 rs546748 chr17:30324293 A/C cg27661571 chr11:113659931 NA -0.61 -8.01 -0.4 2.05e-14 Hip circumference adjusted for BMI; CRC cis rs10857712 0.904 rs7083614 chr10:135226236 G/A cg19904058 chr10:135279010 LOC619207 -0.39 -7.39 -0.38 1.23e-12 Systemic lupus erythematosus; CRC cis rs2204008 0.774 rs11520237 chr12:38266978 G/A cg26384229 chr12:38710491 ALG10B 0.67 9.01 0.44 1.77e-17 Bladder cancer; CRC cis rs66569888 0.754 rs6719028 chr2:106895212 T/C cg16099169 chr2:106886729 NA 0.71 11.93 0.55 1.72e-27 Facial morphology (factor 23); CRC cis rs16975963 0.644 rs11665759 chr19:38039675 C/G cg15135657 chr19:38346511 NA -0.46 -6.24 -0.33 1.32e-9 Longevity; CRC cis rs4713118 0.621 rs9295755 chr6:28033174 C/T cg15845792 chr6:28175446 NA -0.9 -12.11 -0.56 3.63e-28 Parkinson's disease; CRC cis rs9522267 0.535 rs9522303 chr13:112237301 T/C cg10483660 chr13:112241077 NA -0.48 -9.1 -0.45 9.18e-18 Hepatitis; CRC cis rs2991971 0.967 rs2275276 chr1:45973928 C/T cg15605315 chr1:45957053 TESK2 0.42 6.69 0.35 9.71e-11 High light scatter reticulocyte count; CRC cis rs10504229 1.000 rs56255635 chr8:58178264 T/C cg01721255 chr8:58191610 C8orf71 0.49 6.17 0.32 2e-9 Developmental language disorder (linguistic errors); CRC cis rs6089584 0.606 rs7270666 chr20:60577598 C/T cg13770153 chr20:60521292 NA -0.45 -7.61 -0.39 2.91e-13 Body mass index; CRC cis rs853679 0.517 rs9380060 chr6:28132603 G/A cg12273811 chr6:28175739 NA 0.73 9.16 0.45 5.8e-18 Depression; CRC cis rs1129187 0.967 rs11752813 chr6:42928017 C/G cg02353165 chr6:42928485 GNMT 0.85 15.49 0.65 5.13e-41 Alzheimer's disease in APOE e4+ carriers; CRC cis rs9291683 0.605 rs73224439 chr4:10331818 C/A cg11266682 chr4:10021025 SLC2A9 -0.45 -8.39 -0.42 1.46e-15 Bone mineral density; CRC cis rs4629710 0.645 rs34601891 chr6:131551238 C/T cg12606694 chr6:131520996 AKAP7 0.55 8.16 0.41 7.08e-15 Multiple myeloma (IgH translocation); CRC cis rs7224685 0.501 rs1377806 chr17:4019966 A/G cg11204139 chr17:3907470 NA 0.72 13.36 0.59 7.88e-33 Type 2 diabetes; CRC cis rs11650494 0.908 rs78208413 chr17:47398282 G/A cg08112188 chr17:47440006 ZNF652 1.26 11.59 0.54 2.84e-26 Prostate cancer; CRC cis rs9379850 0.527 rs9393704 chr6:26358775 T/C cg16898833 chr6:26189333 HIST1H4D 0.75 6.55 0.34 2.26e-10 Intelligence (multi-trait analysis); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg04498032 chr1:155242826 CLK2 0.46 6.51 0.34 2.77e-10 Response to antipsychotic treatment; CRC cis rs13191362 1.000 rs34931503 chr6:163003876 T/C cg06582575 chr6:163149167 PACRG;PARK2 0.77 10.59 0.5 9.54e-23 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC trans rs6557786 0.636 rs17052934 chr8:24840319 A/C cg17512779 chr8:17104072 CNOT7;VPS37A 0.45 6.01 0.31 4.99e-9 Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 2 peripheral neuropathy); CRC cis rs7786877 0.723 rs73407376 chr7:100215200 C/T cg00334542 chr7:100209784 MOSPD3 -0.68 -7.86 -0.4 5.4e-14 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC trans rs1656966 1.000 rs1656966 chr3:186466252 C/T cg20448748 chr14:31091392 SCFD1 0.4 5.98 0.31 5.7e-9 Myopia (pathological); CRC cis rs6543140 0.964 rs2160200 chr2:103033963 G/T cg04239558 chr2:103089729 SLC9A4 0.37 6.39 0.33 5.69e-10 Blood protein levels; CRC cis rs7666738 0.830 rs28516388 chr4:98987449 A/G cg05340658 chr4:99064831 C4orf37 0.6 9.41 0.46 8.57e-19 Colonoscopy-negative controls vs population controls; CRC cis rs17376456 0.877 rs10061080 chr5:93420559 A/G cg09848695 chr5:92956644 FAM172A;MIR2277 0.67 6.69 0.35 9.81e-11 Diabetic retinopathy; CRC cis rs8141529 0.956 rs132539 chr22:29304253 C/T cg15103426 chr22:29168792 CCDC117 0.46 6.4 0.33 5.23e-10 Lymphocyte counts; CRC cis rs2404602 0.692 rs12595586 chr15:77172210 A/G cg03037974 chr15:76606532 NA 0.68 11.55 0.54 4.06e-26 Blood metabolite levels; CRC cis rs8177253 0.665 rs12493887 chr3:133440737 T/C cg16262614 chr3:133464971 TF 0.33 5.82 0.31 1.41e-8 Iron status biomarkers; CRC cis rs11997175 0.545 rs66783231 chr8:33811467 A/T ch.8.33884649F chr8:33765107 NA 0.44 5.99 0.31 5.4e-9 Body mass index; CRC cis rs3862260 0.509 rs7552885 chr1:120164966 C/T cg16322792 chr1:120165303 ZNF697 0.46 8.03 0.4 1.72e-14 Systemic lupus erythematosus; CRC trans rs3733585 0.673 rs116046986 chr4:9957794 A/G cg26043149 chr18:55253948 FECH -0.49 -7.61 -0.39 2.86e-13 Cleft plate (environmental tobacco smoke interaction); CRC cis rs5753618 0.583 rs34545960 chr22:31812462 G/A cg07713946 chr22:31675144 LIMK2 0.42 6.29 0.33 1.02e-9 Colorectal cancer; CRC cis rs875971 0.658 rs432667 chr7:65514633 A/G cg12463550 chr7:65579703 CRCP 0.45 6.46 0.34 3.7e-10 Aortic root size; CRC cis rs2439831 0.717 rs28495368 chr15:43895642 G/A cg02155558 chr15:43621948 ADAL;LCMT2 0.7 7.74 0.39 1.28e-13 Lung cancer in ever smokers; CRC cis rs9309473 0.607 rs1522926 chr2:73591241 T/C cg20560298 chr2:73613845 ALMS1 -0.51 -6.83 -0.35 4.07e-11 Metabolite levels; CRC cis rs9486715 0.867 rs3860243 chr6:96905303 T/G cg18709589 chr6:96969512 KIAA0776 0.49 7.31 0.37 2.05e-12 Headache; CRC cis rs7666738 0.830 rs28451101 chr4:99001190 T/C cg05340658 chr4:99064831 C4orf37 0.61 9.54 0.47 3.44e-19 Colonoscopy-negative controls vs population controls; CRC cis rs898097 0.783 rs11650335 chr17:80835111 A/G cg16060761 chr17:80687452 NA 0.43 6.17 0.32 2.01e-9 Breast cancer; CRC cis rs11764590 0.694 rs3996323 chr7:2079428 G/T cg14004847 chr7:1930337 MAD1L1 -0.43 -5.78 -0.3 1.72e-8 Neuroticism; CRC cis rs7811142 1.000 rs4472444 chr7:100070758 T/C cg00814883 chr7:100076585 TSC22D4 -0.74 -9.58 -0.47 2.55e-19 Platelet count; CRC cis rs6840360 0.573 rs11099806 chr4:152269116 G/T cg09659197 chr4:152720779 NA 0.34 6.59 0.34 1.7e-10 Intelligence (multi-trait analysis); CRC cis rs10078 0.510 rs2278248 chr5:469570 G/T cg08916839 chr5:415575 AHRR 0.74 7.99 0.4 2.22e-14 Fat distribution (HIV); CRC cis rs736408 0.509 rs13083798 chr3:52649748 A/G cg05573699 chr3:52720067 GNL3;PBRM1 -0.52 -8.09 -0.41 1.13e-14 Bipolar disorder; CRC cis rs1532331 0.966 rs6870418 chr5:43111526 C/T cg09164108 chr5:43007320 NA 0.42 6.35 0.33 7.03e-10 Menarche (age at onset); CRC cis rs951366 0.903 rs823116 chr1:205720483 G/A cg14159672 chr1:205819179 PM20D1 0.44 6.48 0.34 3.41e-10 Menarche (age at onset); CRC cis rs6831352 0.918 rs4699712 chr4:100060490 A/T cg13256891 chr4:100009986 ADH5 -0.65 -8.9 -0.44 3.7e-17 Alcohol dependence; CRC cis rs4716602 0.596 rs10267031 chr7:156159649 A/G cg16983916 chr7:156159713 NA -0.39 -6.9 -0.36 2.74e-11 Anti-saccade response; CRC cis rs7647973 0.626 rs11720705 chr3:49753788 A/G cg13072238 chr3:49761600 GMPPB -0.48 -5.71 -0.3 2.46e-8 Menarche (age at onset); CRC cis rs11105298 0.891 rs10858872 chr12:89872932 C/T cg08166232 chr12:89918718 WDR51B;GALNT4 -0.61 -7.77 -0.39 1.01e-13 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; CRC trans rs9329221 0.507 rs12678938 chr8:10016969 C/T cg06636001 chr8:8085503 FLJ10661 -0.49 -7.49 -0.38 6.35e-13 Neuroticism; CRC cis rs6942756 1.000 rs13235749 chr7:128879678 C/G cg02491457 chr7:128862824 NA -0.75 -10.28 -0.49 1.09e-21 White matter hyperintensity burden; CRC cis rs3760982 0.585 rs11673534 chr19:44298884 G/A cg11993925 chr19:44307056 LYPD5 0.57 10.3 0.49 9.35e-22 Breast cancer (estrogen-receptor negative);Breast cancer; CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg21156815 chr8:22526736 BIN3 0.37 6.18 0.32 1.88e-9 Obesity-related traits; CRC cis rs853679 0.517 rs12332979 chr6:28141548 T/G cg21251018 chr6:28226885 NKAPL 0.47 6.04 0.32 4.16e-9 Depression; CRC trans rs4942242 0.663 rs1390371 chr13:44211727 A/G cg19169023 chr15:41853346 TYRO3 0.58 8.03 0.4 1.72e-14 Response to tocilizumab in rheumatoid arthritis; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg11967727 chr21:47743836 PCNT;C21orf58 0.43 6.37 0.33 6.41e-10 Intelligence (multi-trait analysis); CRC cis rs117623576 0.941 rs7070675 chr10:32407269 G/T cg03047570 chr10:32398778 NA -0.74 -7.18 -0.37 4.8e-12 Anti-saccade response; CRC cis rs10504229 0.683 rs57866073 chr8:58139138 A/G cg22535103 chr8:58192502 C8orf71 -0.73 -9.41 -0.46 8.87e-19 Developmental language disorder (linguistic errors); CRC cis rs12545109 0.800 rs2221919 chr8:57412541 A/C cg09654669 chr8:57350985 NA -0.46 -7.45 -0.38 8.25e-13 Obesity-related traits; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg02473953 chr16:24550417 RBBP6 0.42 5.98 0.31 5.73e-9 Intelligence (multi-trait analysis); CRC cis rs3785574 0.962 rs9944483 chr17:61783553 G/T cg06601766 chr17:61851465 DDX42;CCDC47 -0.58 -8.22 -0.41 4.86e-15 Height; CRC cis rs780096 0.546 rs1528533 chr2:27595756 G/C cg22903471 chr2:27725779 GCKR -0.36 -5.86 -0.31 1.11e-8 Total body bone mineral density; CRC cis rs637571 0.528 rs566266 chr11:65573587 A/C cg04055107 chr11:65626734 MUS81;CFL1 -0.42 -6.01 -0.31 4.95e-9 Eosinophil percentage of white cells; CRC trans rs4927850 1.000 rs7625570 chr3:195747398 A/G cg16724585 chr3:197361211 NA -0.47 -6.98 -0.36 1.64e-11 Pancreatic cancer; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg11816769 chr3:52001952 PCBP4 0.4 6.86 0.35 3.49e-11 Liver disease severity in Alagille syndrome; CRC cis rs6964587 0.610 rs10953056 chr7:91466700 C/T cg17063962 chr7:91808500 NA 0.59 9.04 0.45 1.37e-17 Breast cancer; CRC cis rs1215050 0.791 rs983187 chr4:98816350 A/T cg05340658 chr4:99064831 C4orf37 0.46 6.82 0.35 4.46e-11 Waist-to-hip ratio adjusted for body mass index; CRC cis rs7666738 0.830 rs1527517 chr4:98931907 C/T cg05340658 chr4:99064831 C4orf37 0.6 9.35 0.46 1.41e-18 Colonoscopy-negative controls vs population controls; CRC cis rs9549260 0.599 rs12870023 chr13:41244222 T/A cg21288729 chr13:41239152 FOXO1 0.5 7.6 0.39 3.04e-13 Red blood cell count; CRC cis rs262150 0.567 rs2040897 chr7:158803848 C/T cg19418458 chr7:158789849 NA -0.42 -7.25 -0.37 3.09e-12 Facial morphology (factor 20); CRC cis rs908922 0.676 rs7529441 chr1:152531629 A/G cg09873164 chr1:152488093 CRCT1 -0.39 -6.67 -0.34 1.1e-10 Hair morphology; CRC cis rs7927771 0.965 rs17788930 chr11:47752775 A/G cg20307385 chr11:47447363 PSMC3 -0.5 -6.69 -0.35 9.62e-11 Subjective well-being; CRC cis rs2204008 0.606 rs1581358 chr12:38391582 G/T cg13010199 chr12:38710504 ALG10B 0.46 5.71 0.3 2.46e-8 Bladder cancer; CRC cis rs2011503 0.714 rs113980591 chr19:19565357 G/A cg11584989 chr19:19387371 SF4 0.55 5.72 0.3 2.37e-8 Bipolar disorder; CRC cis rs9303401 0.646 rs9892425 chr17:57241938 C/T cg02118635 chr17:56770003 RAD51C;TEX14 0.42 6.49 0.34 3.15e-10 Cognitive test performance; CRC cis rs3764563 0.877 rs4646526 chr19:15729773 A/G cg20725493 chr19:15740067 CYP4F8 -0.73 -7.29 -0.37 2.37e-12 Inflammatory biomarkers; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg05572765 chr14:91526669 RPS6KA5 0.44 6.42 0.33 4.84e-10 Intelligence (multi-trait analysis); CRC cis rs1003719 0.667 rs6517404 chr21:38494918 C/T cg10648535 chr21:38446584 PIGP;TTC3 0.46 6.52 0.34 2.57e-10 Eye color traits; CRC cis rs72772090 0.539 rs10515249 chr5:96125259 G/A cg17330273 chr5:96107758 CAST;ERAP1 -0.63 -5.96 -0.31 6.43e-9 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs9522267 0.535 rs11069899 chr13:112231553 T/C cg26182253 chr13:112236782 NA 0.31 6.2 0.32 1.71e-9 Hepatitis; CRC cis rs12681287 0.547 rs66808088 chr8:87521212 C/T cg27223183 chr8:87520930 FAM82B -0.56 -7.69 -0.39 1.68e-13 Caudate activity during reward; CRC cis rs6545883 0.929 rs3732171 chr2:61749690 C/T cg15711740 chr2:61764176 XPO1 -0.51 -6.93 -0.36 2.26e-11 Tuberculosis; CRC cis rs7086627 0.515 rs10887905 chr10:82210855 A/T cg00277334 chr10:82204260 NA -0.84 -16.95 -0.68 9.58e-47 Post bronchodilator FEV1; CRC cis rs17376456 0.877 rs7728736 chr5:93404277 C/T cg25358565 chr5:93447407 FAM172A 0.98 10.51 0.5 1.85e-22 Diabetic retinopathy; CRC trans rs916888 0.779 rs199528 chr17:44843136 C/T cg22968622 chr17:43663579 NA 1.45 18.09 0.71 2.95e-51 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs3772130 1.000 rs3772130 chr3:121344140 A/G cg20356878 chr3:121714668 ILDR1 0.49 7.65 0.39 2.22e-13 Cognitive performance; CRC cis rs6963495 0.818 rs6973263 chr7:105170293 A/G cg13798780 chr7:105162888 PUS7 0.68 8.04 0.41 1.59e-14 Bipolar disorder (body mass index interaction); CRC cis rs1799949 1.000 rs8176242 chr17:41217874 C/T cg01879757 chr17:41196368 BRCA1 -0.42 -6.23 -0.32 1.44e-9 Menopause (age at onset); CRC trans rs7819412 0.668 rs920047 chr8:11087475 C/T cg06636001 chr8:8085503 FLJ10661 -0.44 -6.75 -0.35 6.6e-11 Triglycerides; CRC cis rs311392 0.554 rs311423 chr8:55104694 G/A cg06042504 chr8:55087323 NA -0.36 -5.76 -0.3 1.95e-8 Pelvic organ prolapse (moderate/severe); CRC cis rs9527 0.590 rs11191553 chr10:104851396 G/T cg04362960 chr10:104952993 NT5C2 0.61 8.65 0.43 2.34e-16 Arsenic metabolism; CRC cis rs231513 1.000 rs231499 chr17:41973507 C/T cg26893861 chr17:41843967 DUSP3 0.64 6.36 0.33 6.75e-10 Cognitive function; CRC trans rs208520 0.674 rs207103 chr6:66795568 G/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.08 -15.36 -0.65 1.56e-40 Exhaled nitric oxide output; CRC cis rs798502 0.541 rs2644307 chr7:2832973 G/A cg13628971 chr7:2884303 GNA12 0.4 5.88 0.31 1.03e-8 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Inflammatory bowel disease;Waist circumference adjusted for BMI in non-smokers;Ulcerative colitis;Waist circumference adjusted for body mass index;Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction); CRC cis rs1997103 1.000 rs6948112 chr7:55411302 G/A cg17469321 chr7:55412551 NA 0.72 11.28 0.53 3.48e-25 QRS interval (sulfonylurea treatment interaction); CRC cis rs2832191 0.720 rs2832200 chr21:30499165 G/A cg24692254 chr21:30365293 RNF160 -0.67 -11.39 -0.53 1.41e-25 Dental caries; CRC cis rs6952808 0.635 rs12154473 chr7:1982181 A/G cg00106254 chr7:1943704 MAD1L1 0.41 6.26 0.33 1.2e-9 Bipolar disorder and schizophrenia; CRC cis rs644799 1.000 rs11021319 chr11:95523123 C/G cg25478527 chr11:95522999 CEP57;FAM76B 0.52 7.81 0.4 7.75e-14 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs17601876 0.814 rs34784350 chr15:51559552 C/T cg19946085 chr15:51559439 CYP19A1 -0.31 -6.18 -0.32 1.84e-9 Estrone/androstenedione ratio in resected early stage-receptor positive breast cancer; CRC cis rs9549328 0.670 rs2873372 chr13:113613383 A/G cg24588162 chr13:113633484 MCF2L -0.34 -6.06 -0.32 3.7e-9 Systolic blood pressure; CRC cis rs8014204 0.967 rs4903266 chr14:75344941 C/G cg03030879 chr14:75389066 RPS6KL1 0.56 9.17 0.45 5.49e-18 Caffeine consumption; CRC cis rs7605827 0.930 rs2380653 chr2:15635011 C/A cg19274914 chr2:15703543 NA 0.4 6.05 0.32 4e-9 Educational attainment (years of education); CRC cis rs2180341 1.000 rs4895822 chr6:127642703 T/C cg27446573 chr6:127587934 RNF146 0.99 14.36 0.62 1.17e-36 Breast cancer; CRC cis rs2727020 0.521 rs10839285 chr11:49496852 T/G cg02254774 chr11:50257496 LOC441601 0.42 5.83 0.31 1.33e-8 Coronary artery disease; CRC cis rs11148252 0.538 rs9526842 chr13:52727723 T/G cg02158880 chr13:53174818 NA 0.42 6.01 0.31 5.04e-9 Lewy body disease; CRC cis rs10804591 0.606 rs2625998 chr3:129303744 G/A cg21885638 chr3:129306552 PLXND1 -0.41 -6.16 -0.32 2.09e-9 Waist-hip ratio;Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Hip circumference adjusted for BMI;Waist-to-hip ratio adjusted for body mass index; CRC cis rs881375 1.000 rs881375 chr9:123652898 T/C cg09419670 chr9:123605666 PSMD5;LOC253039 0.59 8.63 0.43 2.61e-16 Rheumatoid arthritis; CRC cis rs10193935 0.901 rs13375 chr2:42559288 A/G cg27598129 chr2:42591480 NA -0.53 -6.57 -0.34 1.99e-10 Colonoscopy-negative controls vs population controls; CRC cis rs4713118 0.786 rs200502 chr6:27788062 C/T cg15845792 chr6:28175446 NA 0.68 8.53 0.43 5.38e-16 Parkinson's disease; CRC cis rs1949733 0.543 rs62287446 chr4:8535988 G/A cg11789530 chr4:8429930 ACOX3 -0.48 -6.85 -0.35 3.68e-11 Response to antineoplastic agents; CRC cis rs2749592 0.550 rs4934881 chr10:37914346 A/C cg25427524 chr10:38739819 LOC399744 0.66 10.95 0.52 5.16e-24 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs4728302 0.934 rs10258052 chr7:133635874 T/C cg03336402 chr7:133662267 EXOC4 0.46 6.93 0.36 2.21e-11 Intelligence;Intelligence (multi-trait analysis); CRC cis rs3789045 0.774 rs12029692 chr1:204532323 G/A cg17419461 chr1:204415978 PIK3C2B -0.55 -7.75 -0.39 1.16e-13 Educational attainment (college completion); CRC trans rs11098499 0.954 rs13113483 chr4:120309039 C/T cg25214090 chr10:38739885 LOC399744 0.62 9.74 0.47 7.35e-20 Corneal astigmatism; CRC cis rs2073499 1.000 rs2071802 chr3:50412945 A/G cg09545109 chr3:50388910 TUSC4;CYB561D2 0.64 5.8 0.3 1.58e-8 Schizophrenia; CRC cis rs7043114 0.525 rs12353096 chr9:95031144 T/C cg14631576 chr9:95140430 CENPP -0.3 -5.76 -0.3 1.92e-8 Height; CRC cis rs2841233 0.681 rs2582558 chr14:105347488 A/G cg16576083 chr14:105354267 KIAA0284 -0.43 -7.44 -0.38 9e-13 IgG glycosylation; CRC cis rs11155671 0.530 rs9383914 chr6:150207234 T/G cg07701084 chr6:150067640 NUP43 0.49 7.17 0.37 4.95e-12 Testicular germ cell tumor; CRC cis rs10504229 0.683 rs56741275 chr8:58136108 C/G cg02290350 chr8:58132656 NA -0.58 -8.16 -0.41 7.29e-15 Developmental language disorder (linguistic errors); CRC cis rs1697139 0.583 rs11739603 chr5:66540687 C/T cg11553311 chr5:66541588 NA 0.57 9.79 0.48 4.82e-20 Breast cancer; CRC cis rs12188164 0.543 rs2434694 chr5:462734 C/T cg21625146 chr5:486483 SLC9A3 0.37 5.75 0.3 2.06e-8 Cystic fibrosis severity; CRC cis rs7615952 0.599 rs12496921 chr3:125701948 C/G cg18479299 chr3:125709523 NA -0.52 -6.17 -0.32 2.03e-9 Blood pressure (smoking interaction); CRC cis rs8062405 1.000 rs55991577 chr16:28843025 C/T cg16576597 chr16:28551801 NUPR1 0.48 6.89 0.35 2.93e-11 Cognitive ability (multi-trait analysis);Cognitive ability; CRC cis rs13191362 1.000 rs7769686 chr6:163199467 A/G cg21926612 chr6:163149169 PACRG;PARK2 0.92 12.01 0.55 8.28e-28 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs28386778 0.897 rs2584624 chr17:61904546 A/G cg25654072 chr17:61904446 PSMC5;FTSJ3 0.72 11.24 0.53 5.12e-25 Prudent dietary pattern; CRC cis rs116095464 0.558 rs10057626 chr5:239720 T/G cg22496380 chr5:211416 CCDC127 -0.91 -10.37 -0.5 5.49e-22 Breast cancer; CRC trans rs2727020 0.513 rs10839307 chr11:49609843 A/C cg11707556 chr5:10655725 ANKRD33B -0.4 -7.46 -0.38 7.66e-13 Coronary artery disease; CRC cis rs2629540 0.889 rs17624662 chr10:126408146 A/C cg08799069 chr10:126477246 METTL10 0.63 7.98 0.4 2.4e-14 Cocaine dependence; CRC cis rs9467773 0.566 rs66972160 chr6:26359306 T/C cg09904177 chr6:26538194 HMGN4 -0.45 -6.33 -0.33 7.88e-10 Intelligence (multi-trait analysis); CRC cis rs12142240 0.698 rs17357635 chr1:46808668 G/A cg14993813 chr1:46806288 NSUN4 -0.49 -6.22 -0.32 1.5e-9 Menopause (age at onset); CRC trans rs7937682 1.000 rs7121011 chr11:111568681 C/T cg18187862 chr3:45730750 SACM1L -0.53 -7.4 -0.38 1.16e-12 Primary sclerosing cholangitis; CRC cis rs6952808 0.792 rs11771973 chr7:1950440 C/G cg20295408 chr7:1910781 MAD1L1 -0.42 -5.9 -0.31 9.08e-9 Bipolar disorder and schizophrenia; CRC trans rs2012709 0.869 rs12521288 chr5:32553266 C/G cg03755955 chr8:6424269 MCPH1 0.44 6.43 0.33 4.39e-10 Breast cancer; CRC cis rs10504229 0.593 rs77607045 chr8:58010464 T/C cg02725872 chr8:58115012 NA -0.52 -7.24 -0.37 3.13e-12 Developmental language disorder (linguistic errors); CRC cis rs9372498 0.536 rs9320656 chr6:118894468 A/G cg15382696 chr6:118971807 C6orf204 -0.6 -7.9 -0.4 4.3e-14 Diastolic blood pressure; CRC cis rs8062405 1.000 rs3888190 chr16:28889486 C/A cg08761264 chr16:28874980 SH2B1 -0.43 -5.74 -0.3 2.15e-8 Cognitive ability (multi-trait analysis);Cognitive ability; CRC cis rs9322193 0.736 rs10457851 chr6:150096352 T/A cg00933542 chr6:150070202 PCMT1 0.28 5.63 0.3 3.86e-8 Lung cancer; CRC trans rs1005277 0.579 rs932538 chr10:38381314 T/C cg17830980 chr10:43048298 ZNF37B -0.57 -9.53 -0.47 3.64e-19 Extrinsic epigenetic age acceleration; CRC cis rs9291683 0.551 rs2276961 chr4:10022981 C/T cg11266682 chr4:10021025 SLC2A9 0.53 11.36 0.53 1.82e-25 Bone mineral density; CRC cis rs4930103 0.935 rs11042167 chr11:2020901 G/A cg06197492 chr11:2016605 H19 0.41 6.42 0.33 4.72e-10 DNA methylation (parent-of-origin);DNA methylation (variation); CRC trans rs1814175 0.676 rs11040647 chr11:49935947 A/C cg11707556 chr5:10655725 ANKRD33B -0.52 -9.95 -0.48 1.49e-20 Height; CRC cis rs12477438 0.520 rs2516827 chr2:99772565 C/T cg26064155 chr2:99771622 LIPT1;TSGA10 0.88 16.2 0.67 8.61e-44 Chronic sinus infection; CRC cis rs11098499 0.775 rs2002049 chr4:120257417 A/G cg09307838 chr4:120376055 NA 0.62 9.63 0.47 1.68e-19 Corneal astigmatism; CRC cis rs1799949 0.965 rs11650132 chr17:41326087 T/G cg23758822 chr17:41437982 NA 0.81 13.45 0.6 3.53e-33 Menopause (age at onset); CRC trans rs2303319 0.504 rs62189055 chr2:162625749 C/A cg23247704 chr1:116518985 SLC22A15 -0.73 -6.21 -0.32 1.57e-9 Cognitive function; CRC cis rs4689592 0.546 rs10937782 chr4:7057106 G/C cg06697600 chr4:7070879 GRPEL1 -0.48 -7.18 -0.37 4.62e-12 Monocyte percentage of white cells; CRC cis rs800160 0.777 rs2521288 chr11:2342763 T/G cg09785033 chr11:2336066 TSPAN32 -0.51 -5.95 -0.31 6.78e-9 Bacteremia; CRC cis rs1552244 1.000 rs1552244 chr3:10135577 A/G cg16606324 chr3:10149918 C3orf24 0.69 9.58 0.47 2.42e-19 Alzheimer's disease; CRC cis rs11971779 0.680 rs6946393 chr7:139106169 C/T cg07862535 chr7:139043722 LUC7L2 0.57 7.32 0.37 1.92e-12 Diisocyanate-induced asthma; CRC cis rs9611519 1.000 rs9611510 chr22:41569124 T/C cg03806693 chr22:41940476 POLR3H -0.58 -7.41 -0.38 1.1e-12 Neuroticism; CRC cis rs9322193 0.923 rs9800614 chr6:149965740 G/A cg13206674 chr6:150067644 NUP43 0.67 9.98 0.48 1.13e-20 Lung cancer; CRC trans rs73162807 0.546 rs17752579 chr3:146429635 G/A cg26896787 chr1:228603707 TRIM17 -0.59 -5.99 -0.31 5.61e-9 Platelet-derived growth factor BB levels; CRC cis rs59918340 0.728 rs10875467 chr8:142233396 A/C cg03316587 chr8:142245164 NA 0.42 6.37 0.33 6.23e-10 Immature fraction of reticulocytes; CRC cis rs6912958 0.781 rs7757636 chr6:88256092 T/G cg12350822 chr6:88032061 C6orf162;GJB7 -0.36 -6.76 -0.35 6.35e-11 Monocyte percentage of white cells; CRC cis rs77633900 0.772 rs2469224 chr15:76651327 T/G cg21673338 chr15:77095150 SCAPER -0.74 -6.93 -0.36 2.29e-11 Non-glioblastoma glioma;Glioma; CRC cis rs11997175 0.574 rs4538830 chr8:33653741 C/G cg04338863 chr8:33670619 NA 0.39 6.76 0.35 6.31e-11 Body mass index; CRC cis rs11971779 0.680 rs6946393 chr7:139106169 C/T cg23387468 chr7:139079360 LUC7L2 0.41 7.05 0.36 1.04e-11 Diisocyanate-induced asthma; CRC cis rs12497850 0.931 rs11920534 chr3:48937761 G/T cg07636037 chr3:49044803 WDR6 1.03 18.33 0.71 3.23e-52 Parkinson's disease; CRC cis rs7923609 0.902 rs10822158 chr10:65094383 A/G cg08743896 chr10:65200160 JMJD1C -0.4 -5.77 -0.3 1.81e-8 Educational attainment;Liver enzyme levels (alkaline phosphatase); CRC cis rs2425143 1.000 rs2425093 chr20:34306875 C/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.48 -6.67 -0.35 1.06e-10 Blood protein levels; CRC cis rs6586163 1.000 rs7097572 chr10:90753260 A/G cg13456138 chr10:90753195 FAS -0.44 -6.68 -0.35 1.03e-10 Chronic lymphocytic leukemia; CRC cis rs853679 1.000 rs2799077 chr6:28234597 C/T cg03623178 chr6:28175578 NA 0.69 7.26 0.37 2.9e-12 Depression; CRC cis rs483180 0.512 rs598685 chr1:120215269 G/A cg19096424 chr1:120255104 PHGDH 0.46 6.65 0.34 1.2e-10 Macular telangiectasia type 2; CRC cis rs7512552 0.839 rs6703652 chr1:150465953 T/G cg15654264 chr1:150340011 RPRD2 0.61 8.36 0.42 1.83e-15 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); CRC cis rs13256369 1.000 rs4841016 chr8:8572561 C/T cg18904891 chr8:8559673 CLDN23 0.48 6.4 0.33 5.48e-10 Obesity-related traits; CRC cis rs9747201 1.000 rs55638685 chr17:80107566 G/C cg14673194 chr17:80132900 CCDC57 0.49 6.35 0.33 7.03e-10 Peripheral arterial disease (traffic-related air pollution interaction); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg25135801 chr17:1619658 WDR81;C17orf91 0.44 7.26 0.37 2.87e-12 Liver disease severity in Alagille syndrome; CRC cis rs12541635 0.966 rs34177605 chr8:107065105 G/A cg10147462 chr8:107024639 NA 0.47 7.77 0.39 1.04e-13 Age of smoking initiation; CRC cis rs748404 0.697 rs491804 chr15:43560825 G/A cg02155558 chr15:43621948 ADAL;LCMT2 0.41 6.18 0.32 1.9e-9 Lung cancer; CRC trans rs1005277 0.505 rs200910 chr10:38108176 C/T cg27523141 chr10:43048294 ZNF37B 0.44 6.5 0.34 3.06e-10 Extrinsic epigenetic age acceleration; CRC cis rs887829 0.569 rs4663967 chr2:234653184 A/C cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.46 -7.22 -0.37 3.72e-12 Metabolic traits;Bilirubin levels;Cholelithiasis-related traits in sickle cell anemia;Metabolite levels;Total bilirubin levels in HIV-1 infection;Serum metabolite levels;Blood metabolite levels; CRC cis rs908922 0.676 rs4112785 chr1:152533115 G/C cg09873164 chr1:152488093 CRCT1 0.4 6.75 0.35 6.85e-11 Hair morphology; CRC cis rs6502050 0.835 rs8077926 chr17:80117315 C/A cg02741985 chr17:80059408 CCDC57 0.43 7.18 0.37 4.57e-12 Life satisfaction; CRC cis rs3796619 1.000 rs3796619 chr4:1095281 A/G cg11579758 chr4:1086637 RNF212 0.4 6.51 0.34 2.75e-10 Recombination rate (males); CRC cis rs4713118 0.513 rs1225591 chr6:28148752 G/A cg23161317 chr6:28129485 ZNF389 0.46 6.45 0.33 4.05e-10 Parkinson's disease; CRC cis rs1577917 0.655 rs9359658 chr6:86305769 C/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A 0.56 7.84 0.4 6.5e-14 Response to antipsychotic treatment; CRC cis rs2295359 1.000 rs4655683 chr1:67611613 C/T cg03340356 chr1:67600835 NA 0.25 5.73 0.3 2.25e-8 Psoriasis; CRC cis rs4727027 0.870 rs1534196 chr7:148790591 G/A cg23583168 chr7:148888333 NA -0.91 -15.51 -0.65 4.28e-41 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC cis rs875971 0.502 rs2946580 chr7:65531842 G/A cg02869306 chr7:64672164 INTS4L1 0.45 6.36 0.33 6.8e-10 Aortic root size; CRC trans rs4650994 0.544 rs2476561 chr1:178619900 C/T cg05059571 chr16:84539110 KIAA1609 -0.61 -8.44 -0.42 1.06e-15 HDL cholesterol levels;HDL cholesterol; CRC cis rs6674176 0.628 rs7556565 chr1:44416090 C/T cg12908607 chr1:44402522 ARTN -0.58 -10.41 -0.5 4.06e-22 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Cognitive ability; CRC cis rs365302 1.000 rs531165 chr6:159648220 T/C cg14500486 chr6:159655392 FNDC1 0.44 6.82 0.35 4.31e-11 Coronary heart disease; CRC cis rs11098499 0.909 rs35111518 chr4:120440682 A/G cg09307838 chr4:120376055 NA 0.68 10.32 0.49 8.22e-22 Corneal astigmatism; CRC cis rs7726839 0.540 rs72705102 chr5:659437 T/C cg09021430 chr5:549028 NA -0.73 -8.23 -0.41 4.37e-15 Obesity-related traits; CRC cis rs2204008 0.805 rs12146846 chr12:37985847 C/T cg26384229 chr12:38710491 ALG10B 0.69 9.14 0.45 6.75e-18 Bladder cancer; CRC cis rs2268241 0.938 rs11088251 chr21:34770810 A/C cg14850771 chr21:34775459 IFNGR2 0.71 9.59 0.47 2.22e-19 Obesity-related traits; CRC trans rs637571 0.522 rs679581 chr11:65746653 A/G cg17712092 chr4:129076599 LARP1B 0.71 11.86 0.55 2.92e-27 Eosinophil percentage of white cells; CRC cis rs9296092 0.517 rs56206922 chr6:33522567 C/T cg13560919 chr6:33536144 NA -0.43 -6.17 -0.32 2.04e-9 Age at smoking initiation in chronic obstructive pulmonary disease; CRC cis rs826838 0.934 rs10875647 chr12:38856995 G/A cg13010199 chr12:38710504 ALG10B 0.46 6.0 0.31 5.3300000000000004e-09 Heart rate; CRC cis rs7945718 0.621 rs12281511 chr11:12677295 A/C cg25843174 chr11:12811716 TEAD1 0.39 7.07 0.36 9.43e-12 Educational attainment (years of education); CRC cis rs172166 0.694 rs203892 chr6:28067196 T/C cg20615401 chr6:28092323 ZSCAN16 0.45 5.98 0.31 5.68e-9 Cardiac Troponin-T levels; CRC cis rs554111 0.686 rs519209 chr1:21043790 C/T cg00373020 chr1:21041521 KIF17 -0.36 -5.74 -0.3 2.15e-8 Facial morphology (factor 17, height of vermillion upper lip); CRC cis rs2286885 1.000 rs2286885 chr9:129246487 A/C cg15282417 chr9:129245246 FAM125B 0.46 8.49 0.42 7.04e-16 Intraocular pressure; CRC trans rs2303319 0.504 rs62189042 chr2:162602320 G/T cg22677401 chr17:46026860 NA -0.67 -6.07 -0.32 3.57e-9 Cognitive function; CRC cis rs7493 0.853 rs11770901 chr7:95054480 T/C cg01874867 chr7:94954059 PON1 -0.52 -6.49 -0.34 3.14e-10 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs76878669 0.561 rs7110944 chr11:66118217 C/T cg18002602 chr11:66138449 SLC29A2 -0.32 -6.69 -0.35 9.45e-11 Educational attainment (years of education); CRC cis rs10504229 1.000 rs56344560 chr8:58180626 C/G cg01721255 chr8:58191610 C8orf71 0.49 6.11 0.32 2.81e-9 Developmental language disorder (linguistic errors); CRC cis rs1847505 0.559 rs2323133 chr13:61568946 G/A cg14094164 chr13:61491000 NA 0.33 6.19 0.32 1.77e-9 Polychlorinated biphenyl levels; CRC cis rs79387448 0.745 rs7593444 chr2:103158561 G/A cg00507830 chr2:103233733 NA 0.51 5.61 0.3 4.25e-8 Gut microbiota (bacterial taxa); CRC cis rs1799949 1.000 rs72829113 chr17:41181835 C/T cg19454999 chr17:41278357 BRCA1;NBR2 0.53 7.99 0.4 2.31e-14 Menopause (age at onset); CRC cis rs56114371 0.530 rs169262 chr6:27770890 C/T cg08798685 chr6:27730294 NA -0.5 -6.52 -0.34 2.71e-10 Breast cancer; CRC cis rs2839186 0.616 rs4819213 chr21:47619300 G/A cg09417038 chr21:47716443 C21orf57 0.38 6.64 0.34 1.3100000000000001e-10 Testicular germ cell tumor; CRC cis rs12477438 0.520 rs11123765 chr2:99768064 T/C cg14399236 chr2:99771627 LIPT1;TSGA10 0.83 14.8 0.63 2.35e-38 Chronic sinus infection; CRC trans rs11165623 0.602 rs7521690 chr1:97015761 A/C cg10631902 chr5:14652156 NA -0.42 -7.18 -0.37 4.64e-12 Hip circumference;Waist circumference; CRC cis rs13118159 0.836 rs2276903 chr4:1343405 A/G cg20887711 chr4:1340912 KIAA1530 0.42 5.86 0.31 1.15e-8 Longevity; CRC trans rs10802346 0.545 rs2362253 chr1:246371676 G/A cg13514129 chr1:39547527 MACF1 0.65 9.87 0.48 2.72e-20 Fractional exhaled nitric oxide (childhood); CRC cis rs4604732 0.536 rs12058821 chr1:247649651 G/T cg02104434 chr1:247694406 LOC148824;OR2C3 0.57 8.23 0.41 4.43e-15 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CRC cis rs561341 1.000 rs8069199 chr17:30281845 A/G cg23018236 chr17:30244563 NA -0.57 -7.48 -0.38 6.78e-13 Hip circumference adjusted for BMI; CRC cis rs6912958 0.547 rs451089 chr6:88041859 A/G cg04972856 chr6:88032051 C6orf162;GJB7 0.33 6.23 0.32 1.41e-9 Monocyte percentage of white cells; CRC cis rs6951245 1.000 rs11767527 chr7:1097394 T/C cg26224354 chr7:1096374 C7orf50;GPR146 -0.93 -12.05 -0.55 5.9e-28 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs7811142 0.830 rs11761253 chr7:99939321 C/T cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.59 7.57 0.39 3.87e-13 Platelet count; CRC cis rs7412746 0.658 rs6657388 chr1:150748786 A/G cg17724175 chr1:150552817 MCL1 0.49 7.3 0.37 2.19e-12 Melanoma; CRC trans rs10838798 0.517 rs1967210 chr11:48096692 G/T cg15704280 chr7:45808275 SEPT13 -0.57 -6.15 -0.32 2.22e-9 Height; CRC cis rs1448094 0.872 rs7311150 chr12:86435989 A/T cg18827107 chr12:86230957 RASSF9 -0.37 -5.95 -0.31 6.86e-9 Major depressive disorder; CRC cis rs7666738 0.822 rs11097599 chr4:98959562 T/A cg17366294 chr4:99064904 C4orf37 0.43 7.34 0.38 1.69e-12 Colonoscopy-negative controls vs population controls; CRC cis rs4319547 0.698 rs10744217 chr12:122942070 A/G cg23029597 chr12:123009494 RSRC2 -0.47 -6.06 -0.32 3.69e-9 Body mass index; CRC cis rs10512697 0.655 rs13178645 chr5:3501248 G/A cg19473799 chr5:3511975 NA -0.82 -6.32 -0.33 8.41e-10 Immune response to smallpox vaccine (IL-6); CRC cis rs9611565 0.685 rs169363 chr22:41853117 G/T cg06634786 chr22:41940651 POLR3H 0.58 7.2 0.37 4.21e-12 Vitiligo; CRC cis rs4665809 0.590 rs4665840 chr2:26444962 C/T cg27170947 chr2:26402098 FAM59B -0.59 -7.71 -0.39 1.53e-13 Gut microbiome composition (summer); CRC trans rs6550704 0.687 rs9865314 chr3:22634337 A/G cg00360718 chr10:104192479 CUEDC2 -0.43 -6.54 -0.34 2.4e-10 Daytime sleep phenotypes; CRC cis rs4689388 0.824 rs4467645 chr4:6294305 C/T cg00701064 chr4:6280414 WFS1 0.75 13.24 0.59 2.21e-32 Type 2 diabetes and other traits;Type 2 diabetes; CRC cis rs12451471 0.637 rs12950757 chr17:78096800 T/G cg20811857 chr17:78079795 GAA -0.44 -6.27 -0.33 1.11e-9 Plateletcrit;Mean corpuscular hemoglobin concentration; CRC cis rs2836950 0.565 rs2836945 chr21:40596757 C/T cg06238570 chr21:40685208 BRWD1 -0.6 -8.73 -0.43 1.3e-16 Menarche (age at onset); CRC cis rs4319547 0.695 rs10744211 chr12:122931820 A/G cg23029597 chr12:123009494 RSRC2 -0.55 -6.89 -0.36 2.85e-11 Body mass index; CRC cis rs9926296 0.533 rs12102290 chr16:89812617 C/T cg03388025 chr16:89894329 SPIRE2 0.42 8.33 0.42 2.27e-15 Vitiligo; CRC cis rs2836974 0.666 rs11910705 chr21:40685604 C/T cg11644478 chr21:40555479 PSMG1 -0.65 -9.98 -0.48 1.17e-20 Cognitive function; CRC cis rs7727544 0.716 rs4705926 chr5:131561758 C/T cg02033258 chr5:131593261 PDLIM4 0.35 6.7 0.35 9.32e-11 Blood metabolite levels; CRC cis rs67311347 1.000 rs6801185 chr3:40505060 C/T cg24209194 chr3:40518798 ZNF619 -0.43 -6.48 -0.34 3.43e-10 Renal cell carcinoma; CRC cis rs2839186 0.739 rs2280958 chr21:47642016 C/T cg26721908 chr21:47610096 LSS -0.41 -6.31 -0.33 9.17e-10 Testicular germ cell tumor; CRC cis rs72781680 1.000 rs72796326 chr2:24137047 G/A cg08917208 chr2:24149416 ATAD2B 0.91 9.24 0.45 3.06e-18 Lymphocyte counts; CRC cis rs17767392 1.000 rs34873919 chr14:71780741 C/T cg13720639 chr14:72061746 SIPA1L1 -0.54 -6.9 -0.36 2.71e-11 Mitral valve prolapse; CRC cis rs9487051 0.836 rs9400270 chr6:109607488 G/A cg21918786 chr6:109611834 NA -0.45 -8.24 -0.41 4.21e-15 Reticulocyte fraction of red cells; CRC cis rs172166 0.516 rs1225618 chr6:28129713 A/C cg15845792 chr6:28175446 NA 0.64 9.67 0.47 1.21e-19 Cardiac Troponin-T levels; CRC cis rs7949030 0.626 rs7124057 chr11:62334096 A/G cg22862634 chr11:62369728 EML3;MTA2 0.58 10.31 0.49 8.7e-22 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; CRC trans rs6550704 0.687 rs9865314 chr3:22634337 A/G cg10996143 chr20:1373995 FKBP1A -0.43 -6.42 -0.33 4.65e-10 Daytime sleep phenotypes; CRC cis rs780096 0.506 rs1647286 chr2:27714517 A/T cg02592271 chr2:27665507 KRTCAP3 -0.3 -7.08 -0.36 8.79e-12 Total body bone mineral density; CRC cis rs262150 0.574 rs2730273 chr7:158797754 A/C cg10570241 chr7:158785291 NA 0.45 7.84 0.4 6.3e-14 Facial morphology (factor 20); CRC cis rs8078723 0.901 rs709591 chr17:38175561 T/A cg17344932 chr17:38183730 MED24;SNORD124 -0.46 -7.19 -0.37 4.47e-12 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); CRC cis rs6496667 0.779 rs2301827 chr15:90969195 A/T cg04176472 chr15:90893244 GABARAPL3 0.61 8.61 0.43 3.12e-16 Rheumatoid arthritis; CRC cis rs4803468 1.000 rs6508977 chr19:41909346 A/G cg09537434 chr19:41945824 ATP5SL -0.94 -18.44 -0.71 1.16e-52 Height; CRC cis rs4713118 0.669 rs200997 chr6:27811815 G/A cg20933634 chr6:27740509 NA 0.51 7.35 0.38 1.62e-12 Parkinson's disease; CRC cis rs9640161 0.742 rs2159235 chr7:150017228 T/C cg12556325 chr7:150026731 C7orf29;LRRC61 -0.43 -6.38 -0.33 5.94e-10 Blood protein levels;Circulating chemerin levels; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg25161976 chr11:6411824 SMPD1 0.46 6.27 0.33 1.11e-9 Anxiety disorder; CRC cis rs7726839 0.540 rs72705102 chr5:659437 T/C cg14541582 chr5:601475 NA -0.33 -6.59 -0.34 1.8e-10 Obesity-related traits; CRC cis rs2836974 0.602 rs2836987 chr21:40706594 C/T cg11890956 chr21:40555474 PSMG1 -0.8 -12.13 -0.56 3.07e-28 Cognitive function; CRC cis rs12908161 1.000 rs36033486 chr15:85319692 A/G cg11189052 chr15:85197271 WDR73 0.58 8.43 0.42 1.1e-15 Schizophrenia; CRC cis rs11212617 0.967 rs60683001 chr11:108257787 T/C cg12106634 chr11:108092400 ATM;NPAT 0.44 6.5 0.34 3.03e-10 Response to metformin in type 2 diabetes (glycemic); CRC cis rs561341 0.941 rs2470236 chr17:30304940 G/C cg00745463 chr17:30367425 LRRC37B -0.75 -9.07 -0.45 1.08e-17 Hip circumference adjusted for BMI; CRC cis rs972578 1.000 rs738381 chr22:43404107 T/C cg01576275 chr22:43409880 NA -0.49 -8.14 -0.41 8.5e-15 Mean platelet volume; CRC cis rs11166629 0.883 rs11778878 chr8:135599220 C/T cg27224718 chr8:135614730 ZFAT -0.39 -5.74 -0.3 2.1e-8 Smoking quantity; CRC cis rs62064224 0.614 rs4795700 chr17:30763794 A/G cg25809561 chr17:30822961 MYO1D 0.56 10.01 0.48 9.17e-21 Schizophrenia; CRC cis rs78456975 1.000 rs13413096 chr2:1553588 G/A cg12573674 chr2:1569213 NA -0.75 -7.87 -0.4 5.22e-14 Placebo response in major depressive disorder (% change in symptom score); CRC cis rs3087591 0.960 rs757384 chr17:29596135 C/T cg24425628 chr17:29625626 OMG;NF1 0.87 16.52 0.67 4.47e-45 Hip circumference; CRC cis rs9322193 0.923 rs9689716 chr6:149976798 G/A cg07701084 chr6:150067640 NUP43 0.55 8.11 0.41 1.01e-14 Lung cancer; CRC cis rs76878669 0.561 rs905770 chr11:66156765 A/G cg18002602 chr11:66138449 SLC29A2 0.31 6.49 0.34 3.1e-10 Educational attainment (years of education); CRC cis rs4819052 0.807 rs4819047 chr21:46665139 C/T cg02159808 chr21:46707872 POFUT2;LOC642852 0.5 6.56 0.34 2.03e-10 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs7843479 0.601 rs9969551 chr8:21860007 T/C cg17168535 chr8:21777572 XPO7 0.6 10.0 0.48 1.01e-20 Mean corpuscular volume; CRC cis rs1451375 0.741 rs55738142 chr7:50632326 T/C cg18232548 chr7:50535776 DDC 0.45 6.32 0.33 8.47e-10 Malaria; CRC cis rs3741404 0.537 rs1123251 chr11:63917601 G/T cg06243084 chr11:63990629 FERMT3 0.37 5.73 0.3 2.25e-8 Platelet count; CRC trans rs2055729 0.645 rs7828229 chr8:9742841 C/T cg06636001 chr8:8085503 FLJ10661 -0.55 -7.02 -0.36 1.27e-11 Multiple myeloma (hyperdiploidy); CRC cis rs6141769 0.542 rs6057632 chr20:31319841 A/G cg13636640 chr20:31349939 DNMT3B -0.44 -6.35 -0.33 7.11e-10 Subjective well-being; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg27367768 chr5:171615456 STK10 0.44 7.79 0.39 8.85e-14 Liver disease severity in Alagille syndrome; CRC cis rs929354 0.772 rs7778193 chr7:156980087 C/T cg17757837 chr7:157058334 UBE3C 0.74 12.51 0.57 1.22e-29 Body mass index; CRC cis rs2228479 0.850 rs3785279 chr16:89824562 G/C cg06558623 chr16:89946397 TCF25 1.13 10.45 0.5 2.85e-22 Skin colour saturation; CRC cis rs7843479 1.000 rs13248727 chr8:21842063 T/C cg17168535 chr8:21777572 XPO7 0.56 9.05 0.45 1.29e-17 Mean corpuscular volume; CRC cis rs4282054 0.631 rs13081155 chr3:52732429 A/G cg15147215 chr3:52552868 STAB1 -0.7 -12.72 -0.57 2.1000000000000002e-30 Cognitive function; CRC cis rs7659604 0.539 rs1507995 chr4:122748308 G/A cg19748678 chr4:122722346 EXOSC9 0.65 10.43 0.5 3.44e-22 Type 2 diabetes; CRC cis rs7429990 0.965 rs1137524 chr3:47956424 C/T cg11946769 chr3:48343235 NME6 0.45 5.92 0.31 8.17e-9 Educational attainment (years of education); CRC cis rs10919791 0.539 rs10919786 chr1:199946176 A/G cg13229857 chr1:200006247 NR5A2 0.45 6.77 0.35 6.06e-11 Pancreatic cancer; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg01117627 chr14:100150713 CYP46A1 0.43 6.67 0.35 1.11e-10 Liver disease severity in Alagille syndrome; CRC cis rs10870270 0.956 rs7915388 chr10:133734972 G/A cg17892150 chr10:133769511 PPP2R2D -0.72 -10.94 -0.52 5.62e-24 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; CRC cis rs4737010 0.644 rs518718 chr8:41611375 T/C cg17182837 chr8:41585554 ANK1 0.53 7.6 0.39 3.1400000000000003e-13 Lymphocyte counts;High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Reticulocyte count;Reticulocyte fraction of red cells;Mean corpuscular volume;Immature fraction of reticulocytes;Mean corpuscular hemoglobin concentration; CRC cis rs870825 0.929 rs10015218 chr4:185589789 T/C cg07424746 chr4:185654737 MLF1IP -0.58 -5.76 -0.3 1.96e-8 Blood protein levels; CRC cis rs7107174 1.000 rs2511190 chr11:77988310 T/C cg02023728 chr11:77925099 USP35 0.48 6.99 0.36 1.49e-11 Testicular germ cell tumor; CRC cis rs9837602 1.000 rs10049383 chr3:99748548 T/C cg07805332 chr3:99536008 MIR548G;C3orf26 -0.48 -6.24 -0.33 1.31e-9 Breast cancer; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg16779626 chr15:41709933 RTF1 0.46 6.59 0.34 1.77e-10 Response to antipsychotic treatment; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg17848531 chr2:182756352 SSFA2 0.51 7.24 0.37 3.28e-12 Response to antipsychotic treatment; CRC cis rs9733 0.818 rs10888388 chr1:150687296 C/T cg18016565 chr1:150552671 MCL1 -0.42 -6.26 -0.33 1.18e-9 Tonsillectomy; CRC cis rs9368481 0.761 rs12661756 chr6:27003483 A/G cg05192639 chr6:26864778 GUSBL1 0.33 5.66 0.3 3.34e-8 Autism spectrum disorder or schizophrenia; CRC cis rs6952808 0.895 rs4513875 chr7:1928159 C/T cg04267008 chr7:1944627 MAD1L1 -0.83 -12.67 -0.57 3.14e-30 Bipolar disorder and schizophrenia; CRC cis rs6785206 0.803 rs2712380 chr3:128338661 A/C cg16766828 chr3:128327626 NA -0.51 -5.76 -0.3 1.93e-8 Lymphocyte percentage of white cells; CRC cis rs7119 1.000 rs7119 chr15:77777632 C/T cg27398640 chr15:77910606 LINGO1 -0.33 -6.04 -0.32 4.21e-9 Type 2 diabetes; CRC cis rs2032447 0.933 rs1540275 chr6:26036476 T/C cg03517284 chr6:25882590 NA -0.51 -6.96 -0.36 1.83e-11 Intelligence (multi-trait analysis); CRC cis rs4481887 0.927 rs10157089 chr1:248488157 A/G cg00666640 chr1:248458726 OR2T12 0.46 7.93 0.4 3.55e-14 Common traits (Other); CRC cis rs523522 0.962 rs11065149 chr12:120956963 G/A cg27279351 chr12:120934652 DYNLL1 0.78 11.48 0.53 7.05e-26 High light scatter reticulocyte count; CRC cis rs6908034 0.607 rs73376651 chr6:19805559 C/G cg02682789 chr6:19804855 NA 0.8 6.74 0.35 6.9e-11 Endometriosis;Deep ovarian and/or rectovaginal disease with dense adhesions; CRC cis rs9527 0.662 rs4919686 chr10:104592249 A/C cg15744005 chr10:104629667 AS3MT -0.35 -6.26 -0.33 1.18e-9 Arsenic metabolism; CRC cis rs453301 0.571 rs2929454 chr8:9083854 A/C cg06636001 chr8:8085503 FLJ10661 -0.58 -9.19 -0.45 4.69e-18 Joint mobility (Beighton score); CRC trans rs875971 0.545 rs1547529 chr7:65723846 T/C cg02869306 chr7:64672164 INTS4L1 -0.43 -6.26 -0.33 1.2e-9 Aortic root size; CRC cis rs853679 0.517 rs1947863 chr6:28099344 G/A cg12273811 chr6:28175739 NA 0.73 9.36 0.46 1.34e-18 Depression; CRC cis rs2204008 0.743 rs2132212 chr12:38039405 G/A cg26384229 chr12:38710491 ALG10B 0.65 9.86 0.48 2.84e-20 Bladder cancer; CRC cis rs7613875 0.620 rs2526747 chr3:50082914 C/G cg24110177 chr3:50126178 RBM5 -0.56 -8.36 -0.42 1.75e-15 Body mass index; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg10227393 chr19:3721525 NA 0.41 5.99 0.31 5.6e-9 Intelligence (multi-trait analysis); CRC cis rs780096 0.545 rs6716894 chr2:27583273 A/G cg21248554 chr2:27665150 KRTCAP3 -0.27 -6.08 -0.32 3.25e-9 Total body bone mineral density; CRC trans rs2014572 0.967 rs10427146 chr19:57755998 T/C cg02674126 chr19:40336878 FBL 0.43 6.91 0.36 2.58e-11 Hyperactive-impulsive symptoms; CRC cis rs28386778 0.897 rs2854213 chr17:61945631 T/C cg11494091 chr17:61959527 GH2 0.61 10.31 0.49 8.74e-22 Prudent dietary pattern; CRC cis rs6456156 0.811 rs975822 chr6:167516458 C/T cg05540913 chr6:167530185 CCR6 -0.33 -5.76 -0.3 1.92e-8 Primary biliary cholangitis; CRC cis rs2274471 0.582 rs57839907 chr9:5082671 T/A cg03390472 chr9:5043263 JAK2 -0.6 -7.05 -0.36 1.03e-11 Crohn's disease; CRC cis rs1451375 0.617 rs880029 chr7:50569927 G/C cg18232548 chr7:50535776 DDC -0.43 -5.62 -0.3 4.12e-8 Malaria; CRC cis rs6831352 0.918 rs29001214 chr4:100051733 A/G cg12011299 chr4:100065546 ADH4 -0.49 -9.21 -0.45 4.04e-18 Alcohol dependence; CRC cis rs9300255 0.537 rs10772993 chr12:123644714 A/G cg00376283 chr12:123451042 ABCB9 0.56 6.93 0.36 2.18e-11 Neutrophil percentage of white cells; CRC cis rs12745968 0.595 rs6604014 chr1:93215718 T/C cg17283838 chr1:93427260 FAM69A -0.44 -5.97 -0.31 5.99e-9 Bipolar disorder and schizophrenia; CRC cis rs5758511 0.680 rs5758651 chr22:42609148 T/C cg00645731 chr22:42541494 CYP2D7P1 0.65 10.03 0.48 8.03e-21 Birth weight; CRC cis rs10791323 0.604 rs2723607 chr11:133711018 C/G cg00579200 chr11:133705235 NA -0.39 -5.65 -0.3 3.48e-8 Childhood ear infection; CRC cis rs77956314 0.515 rs9804817 chr12:117440220 G/A cg02017074 chr12:117425053 FBXW8 -0.66 -8.5 -0.42 6.67e-16 Subcortical brain region volumes;Hippocampal volume; CRC cis rs2573652 1.000 rs2581363 chr15:100513364 G/A cg00587665 chr15:100533223 ADAMTS17 -0.36 -6.06 -0.32 3.71e-9 Height; CRC cis rs798554 1.000 rs798540 chr7:2764130 G/A cg17321639 chr7:2759063 NA -0.51 -6.79 -0.35 5.27e-11 Height; CRC trans rs9291683 0.655 rs3822242 chr4:10094904 T/C cg26043149 chr18:55253948 FECH -0.56 -8.84 -0.44 5.8e-17 Bone mineral density; CRC cis rs6964587 0.967 rs7786031 chr7:91649001 T/G cg17063962 chr7:91808500 NA 0.8 14.35 0.62 1.28e-36 Breast cancer; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg24542852 chr12:569111 B4GALNT3 0.45 7.27 0.37 2.68e-12 Liver disease severity in Alagille syndrome; CRC cis rs11098499 0.909 rs10002083 chr4:120311152 C/T cg09307838 chr4:120376055 NA 0.71 10.93 0.52 6.41e-24 Corneal astigmatism; CRC cis rs8060686 0.920 rs2292318 chr16:67985706 C/T cg26727032 chr16:67993705 SLC12A4 -0.59 -6.73 -0.35 7.48e-11 HDL cholesterol;Metabolic syndrome; CRC cis rs9372498 0.536 rs9489433 chr6:118867006 G/A cg10217327 chr6:118973057 C6orf204 0.51 5.86 0.31 1.12e-8 Diastolic blood pressure; CRC cis rs7666738 0.830 rs10025174 chr4:98914172 A/G cg17366294 chr4:99064904 C4orf37 0.41 6.72 0.35 8.14e-11 Colonoscopy-negative controls vs population controls; CRC cis rs853679 0.723 rs1736904 chr6:28219270 G/A cg23161317 chr6:28129485 ZNF389 0.47 5.61 0.3 4.34e-8 Depression; CRC cis rs1784581 0.894 rs1790000 chr6:162388707 A/G cg17173639 chr6:162384350 PARK2 0.83 14.71 0.63 5.35e-38 Itch intensity from mosquito bite; CRC cis rs7927771 0.524 rs10838771 chr11:47831332 A/G cg20307385 chr11:47447363 PSMC3 -0.46 -6.76 -0.35 6.47e-11 Subjective well-being; CRC cis rs10504229 0.638 rs7826839 chr8:58132075 G/T cg22535103 chr8:58192502 C8orf71 -0.7 -9.34 -0.46 1.47e-18 Developmental language disorder (linguistic errors); CRC cis rs6502050 0.723 rs11657069 chr17:80083809 C/T cg25804541 chr17:80189381 SLC16A3 0.31 5.9 0.31 8.94e-9 Life satisfaction; CRC cis rs2486012 0.649 rs1354261 chr1:44256682 A/C cg12908607 chr1:44402522 ARTN -0.42 -6.09 -0.32 3.18e-9 Intelligence (multi-trait analysis); CRC cis rs2463822 0.920 rs11828383 chr11:62067818 C/T cg06239285 chr11:62104954 ASRGL1 -0.92 -9.54 -0.47 3.29e-19 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs2976388 1.000 rs2976392 chr8:143762932 G/A cg04969067 chr8:143858791 LYNX1 -0.34 -5.76 -0.3 1.92e-8 Urinary tract infection frequency; CRC cis rs2842992 0.747 rs733319 chr6:160221475 A/G cg19482086 chr6:160211437 TCP1;MRPL18 0.75 9.52 0.46 3.77e-19 Age-related macular degeneration (geographic atrophy); CRC cis rs7851660 0.506 rs1912996 chr9:100598261 G/T cg13688889 chr9:100608707 NA -0.47 -6.03 -0.32 4.44e-9 Strep throat; CRC cis rs1008375 0.966 rs2315645 chr4:17579678 G/C cg02297831 chr4:17616191 MED28 0.44 5.78 0.3 1.74e-8 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs2160860 0.825 rs10113563 chr8:39806028 C/A cg11363097 chr8:39792086 IDO2 -0.4 -6.7 -0.35 9.23e-11 Blood metabolite levels; CRC cis rs7258465 1.000 rs7258465 chr19:18533642 A/G cg06462663 chr19:18546047 ISYNA1 0.46 6.96 0.36 1.83e-11 Breast cancer; CRC cis rs7177699 0.557 rs4073322 chr15:79122541 G/C cg15571903 chr15:79123663 NA 0.32 6.3 0.33 9.36e-10 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; CRC cis rs1451375 0.652 rs10265930 chr7:50627449 C/T cg14593290 chr7:50529359 DDC 0.54 6.83 0.35 4.04e-11 Malaria; CRC cis rs4664293 0.867 rs13022404 chr2:160589492 C/A cg08347373 chr2:160653686 CD302 -0.49 -7.7 -0.39 1.64e-13 Monocyte percentage of white cells; CRC cis rs72717009 0.825 rs7529225 chr1:161479352 G/A cg15358701 chr1:161410459 NA -0.61 -6.57 -0.34 2.02e-10 Rheumatoid arthritis; CRC trans rs1814175 0.817 rs1390676 chr11:50056778 C/T cg11707556 chr5:10655725 ANKRD33B -0.42 -8.03 -0.4 1.75e-14 Height; CRC cis rs4731207 0.596 rs7787605 chr7:124659982 A/G cg23710748 chr7:124431027 NA -0.37 -5.88 -0.31 1.03e-8 Cutaneous malignant melanoma; CRC cis rs1218582 0.744 rs6674853 chr1:154892753 G/C cg24250549 chr1:154909240 PMVK 0.63 9.89 0.48 2.26e-20 Prostate cancer; CRC cis rs6860806 0.531 rs272888 chr5:131665423 T/C cg22638593 chr5:131593259 PDLIM4 0.38 6.19 0.32 1.75e-9 Breast cancer; CRC cis rs11764590 0.715 rs9639202 chr7:2087315 G/A cg23422044 chr7:1970798 MAD1L1 -0.53 -6.28 -0.33 1.07e-9 Neuroticism; CRC cis rs6700896 0.931 rs11208717 chr1:66158994 T/C cg04111102 chr1:66153794 NA 0.34 5.87 0.31 1.04e-8 C-reactive protein;Mean corpuscular volume;Mean corpuscular hemoglobin; CRC cis rs1448094 0.512 rs6539928 chr12:86244920 G/A cg02569458 chr12:86230093 RASSF9 0.42 7.2 0.37 4.01e-12 Major depressive disorder; CRC cis rs1707322 1.000 rs785498 chr1:46592414 C/T cg06784218 chr1:46089804 CCDC17 -0.56 -9.73 -0.47 7.7e-20 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs34864796 0.547 rs200476 chr6:27768348 A/T cg02683197 chr6:28174875 NA 0.53 6.18 0.32 1.85e-9 Lung function (FEV1);Lung function (FEV1/FVC);Lung function (FVC); CRC cis rs12291225 0.679 rs11369 chr11:14288096 A/G cg19336497 chr11:14380999 RRAS2 -0.51 -8.59 -0.43 3.61e-16 Sense of smell; CRC cis rs651907 0.557 rs3806654 chr3:101396529 G/C cg11279151 chr3:101281821 RG9MTD1 -0.5 -6.87 -0.35 3.12e-11 Colorectal cancer; CRC trans rs7448080 0.702 rs62371209 chr5:123306655 A/C cg23202058 chr4:185139648 ENPP6 0.59 5.99 0.31 5.55e-9 Alcohol dependence (age at onset); CRC cis rs10504229 0.636 rs72649123 chr8:58045789 A/T cg21724239 chr8:58056113 NA 0.53 7.05 0.36 1.06e-11 Developmental language disorder (linguistic errors); CRC cis rs1707322 0.752 rs7529699 chr1:46134634 C/T cg06784218 chr1:46089804 CCDC17 0.65 12.18 0.56 2e-28 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs2000999 0.514 rs36061252 chr16:72217613 T/G cg04254540 chr16:71951199 KIAA0174 -0.69 -5.78 -0.3 1.71e-8 Total cholesterol levels;Cholesterol, total;Blood protein levels;LDL cholesterol levels;Haptoglobin levels;LDL cholesterol; CRC cis rs523522 0.926 rs10774555 chr12:120971978 G/A cg27279351 chr12:120934652 DYNLL1 0.77 11.31 0.53 2.81e-25 High light scatter reticulocyte count; CRC cis rs7914558 0.902 rs3736922 chr10:104850632 A/G cg15744005 chr10:104629667 AS3MT 0.32 6.7 0.35 8.96e-11 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs9303401 0.527 rs12939313 chr17:56755616 A/T cg10487724 chr17:56770010 TEX14;RAD51C 0.75 8.46 0.42 8.84e-16 Cognitive test performance; CRC trans rs61931739 0.500 rs11053277 chr12:34553835 T/A cg13010199 chr12:38710504 ALG10B 0.46 6.57 0.34 2.02e-10 Morning vs. evening chronotype; CRC cis rs7727544 0.709 rs272852 chr5:131688767 G/A cg11843238 chr5:131593191 PDLIM4 0.32 5.94 0.31 7.33e-9 Blood metabolite levels; CRC cis rs644799 0.710 rs11021311 chr11:95505227 G/A cg25478527 chr11:95522999 CEP57;FAM76B 0.5 7.57 0.39 3.74e-13 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs8067545 0.611 rs12603372 chr17:20181566 C/T cg13482628 chr17:19912719 NA 0.46 7.38 0.38 1.33e-12 Schizophrenia; CRC cis rs2179367 0.959 rs4895788 chr6:149748091 G/A cg07828024 chr6:149772892 ZC3H12D -0.37 -6.02 -0.32 4.61e-9 Dupuytren's disease; CRC cis rs4076764 0.515 rs4657268 chr1:163376507 A/T cg24596788 chr1:163392923 NA -0.5 -7.79 -0.39 9.08e-14 Motion sickness; CRC cis rs4713118 0.955 rs9468204 chr6:27688809 C/T cg15845792 chr6:28175446 NA 0.59 7.85 0.4 6.08e-14 Parkinson's disease; CRC cis rs9322193 0.962 rs1112730 chr6:150087519 G/A cg13206674 chr6:150067644 NUP43 0.57 8.19 0.41 5.85e-15 Lung cancer; CRC cis rs2832191 0.632 rs1984011 chr21:30337831 T/A cg24692254 chr21:30365293 RNF160 -0.86 -15.88 -0.66 1.51e-42 Dental caries; CRC cis rs7811142 1.000 rs4989959 chr7:100032288 T/C cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.17 17.56 0.7 3.65e-49 Platelet count; CRC cis rs11690935 0.959 rs7608403 chr2:172646765 A/C cg13550731 chr2:172543902 DYNC1I2 -1.05 -18.51 -0.71 6.13e-53 Schizophrenia; CRC trans rs10242455 0.702 rs73397447 chr7:99010949 G/T cg09045935 chr12:6379348 NA 1.02 8.04 0.41 1.67e-14 Blood metabolite levels; CRC cis rs6951245 0.580 rs77101766 chr7:1122438 A/G cg23978390 chr7:1156363 C7orf50 0.53 5.88 0.31 9.97e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg21037892 chr2:96874728 STARD7 0.46 6.01 0.31 4.96e-9 Thyroid stimulating hormone; CRC cis rs7524258 0.868 rs2412153 chr1:7272412 C/T cg07173049 chr1:7289937 CAMTA1 0.55 9.11 0.45 8.06e-18 Tourette's syndrome or obsessive-compulsive disorder; CRC cis rs9291683 0.566 rs13122689 chr4:10044648 A/G cg00071950 chr4:10020882 SLC2A9 0.63 11.19 0.52 7.86e-25 Bone mineral density; CRC cis rs7131987 0.903 rs10843373 chr12:29420608 A/T cg09582351 chr12:29534625 ERGIC2 -0.29 -6.19 -0.32 1.81e-9 QT interval; CRC cis rs7927771 0.864 rs2293577 chr11:47437202 C/T cg20307385 chr11:47447363 PSMC3 0.6 8.96 0.44 2.42e-17 Subjective well-being; CRC cis rs10463316 0.779 rs6861968 chr5:150817725 C/T cg03212797 chr5:150827313 SLC36A1 -0.47 -7.24 -0.37 3.17e-12 Metabolite levels (Pyroglutamine); CRC cis rs66573146 0.831 rs6851488 chr4:6987412 C/T cg00086871 chr4:6988644 TBC1D14 1.06 9.68 0.47 1.19e-19 Granulocyte percentage of myeloid white cells; CRC cis rs7772486 0.790 rs2265469 chr6:146219049 T/C cg13319975 chr6:146136371 FBXO30 -0.41 -6.16 -0.32 2.18e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs6500602 0.701 rs4786508 chr16:4568043 G/A cg06139259 chr16:4526053 HMOX2;NMRAL1 0.51 6.59 0.34 1.7e-10 Schizophrenia; CRC cis rs1552244 0.608 rs6764807 chr3:9998803 T/C cg13047869 chr3:10149882 C3orf24 0.36 5.73 0.3 2.27e-8 Alzheimer's disease; CRC cis rs1552244 0.882 rs34779351 chr3:10021801 A/G cg13047869 chr3:10149882 C3orf24 0.51 6.91 0.36 2.54e-11 Alzheimer's disease; CRC cis rs9649213 0.593 rs12704982 chr7:97926053 C/T cg21770322 chr7:97807741 LMTK2 0.5 8.23 0.41 4.49e-15 Prostate cancer (SNP x SNP interaction); CRC cis rs7584330 0.518 rs74003106 chr2:238447004 A/G cg08992911 chr2:238395768 MLPH 0.61 6.25 0.33 1.26e-9 Prostate cancer; CRC cis rs9517320 0.515 rs9556969 chr13:99195948 T/C cg07423050 chr13:99094983 FARP1 -0.53 -7.52 -0.38 5.39e-13 Longevity; CRC cis rs6460942 0.915 rs79232243 chr7:12459494 G/A cg20607287 chr7:12443886 VWDE -0.66 -6.93 -0.36 2.17e-11 Coronary artery disease; CRC cis rs1865760 0.573 rs7450342 chr6:25919480 T/C cg17691542 chr6:26056736 HIST1H1C 0.45 6.93 0.36 2.21e-11 Height; CRC cis rs9814567 1.000 rs1863913 chr3:134200205 C/T cg06109529 chr3:134205091 CEP63;ANAPC13 -0.82 -12.2 -0.56 1.68e-28 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs73206853 0.563 rs73194026 chr12:111140219 G/T cg12870014 chr12:110450643 ANKRD13A 0.81 9.11 0.45 8.06e-18 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC cis rs2882667 0.690 rs9327829 chr5:138261671 A/G cg09476006 chr5:138032270 NA -0.56 -9.3 -0.46 2.06e-18 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs7249142 0.549 rs10854012 chr19:19295719 C/T cg08207377 chr19:19281140 LOC729991-MEF2B;MEF2B -0.36 -5.77 -0.3 1.85e-8 IgG glycosylation; CRC trans rs2303319 0.504 rs79046651 chr2:162326417 C/A cg04145477 chr6:107077629 RTN4IP1;QRSL1 -0.84 -6.27 -0.33 1.13e-9 Cognitive function; CRC cis rs13082711 0.911 rs34316374 chr3:27437385 G/C cg02860705 chr3:27208620 NA 0.62 8.9 0.44 3.8e-17 Systolic blood pressure;Diastolic blood pressure;Blood pressure; CRC cis rs875971 0.862 rs10224872 chr7:65759773 T/A cg18252515 chr7:66147081 NA 0.39 5.7 0.3 2.73e-8 Aortic root size; CRC trans rs1814175 0.817 rs7947286 chr11:49874657 C/T cg15704280 chr7:45808275 SEPT13 -1.01 -20.25 -0.74 8.67e-60 Height; CRC cis rs1005277 0.522 rs1208767 chr10:38042295 G/T cg00409905 chr10:38381863 ZNF37A -0.64 -10.64 -0.51 6.58e-23 Extrinsic epigenetic age acceleration; CRC cis rs7635838 0.892 rs4684773 chr3:11418508 C/T cg00170343 chr3:11313890 ATG7 0.42 6.37 0.33 6.35e-10 HDL cholesterol; CRC cis rs208520 0.690 rs4710564 chr6:66823478 A/G cg07460842 chr6:66804631 NA 1.03 14.37 0.62 1.14e-36 Exhaled nitric oxide output; CRC cis rs11971779 0.680 rs6467843 chr7:139070523 A/G cg23387468 chr7:139079360 LUC7L2 0.41 7.04 0.36 1.14e-11 Diisocyanate-induced asthma; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg04988224 chr19:49122379 RPL18;SPHK2 0.39 6.02 0.31 4.73e-9 Intelligence (multi-trait analysis); CRC cis rs853679 0.517 rs9380061 chr6:28132803 T/C cg12172441 chr6:28176163 NA 0.64 7.53 0.38 5.03e-13 Depression; CRC cis rs57221529 0.709 rs111352378 chr5:577079 G/A cg09021430 chr5:549028 NA -0.72 -7.86 -0.4 5.63e-14 Lung disease severity in cystic fibrosis; CRC cis rs62064224 0.597 rs7207268 chr17:30725155 T/G cg09324608 chr17:30823087 MYO1D 0.33 5.65 0.3 3.4e-8 Schizophrenia; CRC cis rs34375054 0.624 rs12826658 chr12:125680237 A/G cg02766259 chr12:125626809 AACS -0.47 -7.64 -0.39 2.34e-13 Post bronchodilator FEV1/FVC ratio; CRC cis rs9372498 0.536 rs9320656 chr6:118894468 A/G cg01339444 chr6:118972232 C6orf204 -0.51 -5.86 -0.31 1.1e-8 Diastolic blood pressure; CRC trans rs1973993 0.691 rs553785 chr1:96895325 G/A cg10631902 chr5:14652156 NA 0.62 12.35 0.56 4.76e-29 Weight; CRC cis rs7945705 0.714 rs2653570 chr11:8987823 A/G cg12365402 chr11:9010492 NRIP3 -0.61 -11.48 -0.53 7.12e-26 Hemoglobin concentration; CRC cis rs989128 0.642 rs8077323 chr17:48626398 C/T cg16068336 chr17:48637367 CACNA1G -0.54 -7.73 -0.39 1.3e-13 Type 2 diabetes; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg00521598 chr1:39339413 MYCBP 0.44 6.2 0.32 1.65e-9 Intelligence (multi-trait analysis); CRC cis rs7589342 0.862 rs10469862 chr2:106509907 C/T cg16077055 chr2:106428750 NCK2 0.4 5.7 0.3 2.66e-8 Addiction; CRC trans rs2303319 0.504 rs56371522 chr2:162491109 G/A cg13490827 chr1:46269305 MAST2 -0.72 -6.21 -0.32 1.56e-9 Cognitive function; CRC cis rs7223966 1.000 rs8074771 chr17:61735865 C/T cg23090583 chr17:61904693 PSMC5;FTSJ3 0.48 6.08 0.32 3.33e-9 Hip circumference adjusted for BMI;Body mass index; CRC cis rs2576037 0.899 rs7233515 chr18:44585955 A/G cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.46 7.06 0.36 9.94e-12 Personality dimensions; CRC cis rs9457247 1.000 rs4710147 chr6:167374239 G/A cg23791538 chr6:167370224 RNASET2 0.39 6.07 0.32 3.46e-9 Crohn's disease; CRC cis rs1707322 1.000 rs7547284 chr1:46319565 C/G cg03146154 chr1:46216737 IPP 0.5 6.95 0.36 1.97e-11 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs67311347 1.000 rs17078941 chr3:40450888 A/G cg09455208 chr3:40491958 NA -0.46 -9.06 -0.45 1.2e-17 Renal cell carcinoma; CRC cis rs6500602 0.561 rs62039231 chr16:4519548 A/G cg08645402 chr16:4508243 NA 0.64 11.13 0.52 1.22e-24 Schizophrenia; CRC cis rs7131987 0.903 rs67517901 chr12:29421346 A/G cg09582351 chr12:29534625 ERGIC2 -0.33 -7.11 -0.36 7.38e-12 QT interval; CRC cis rs12368653 1.000 rs12371356 chr12:58135420 T/C cg02175503 chr12:58329896 NA -0.48 -6.74 -0.35 7.19e-11 Multiple sclerosis; CRC trans rs79464052 0.571 rs79215142 chr5:140999104 C/T cg05255351 chr5:1503979 LPCAT1 -0.46 -6.09 -0.32 3.07e-9 Diffuse large B cell lymphoma; CRC cis rs9308731 0.644 rs1837367 chr2:111874551 G/A cg18646521 chr2:111875858 NA 0.36 5.65 0.3 3.55e-8 Chronic lymphocytic leukemia; CRC cis rs875971 0.800 rs427557 chr7:65519250 A/G cg12463550 chr7:65579703 CRCP 0.45 6.43 0.33 4.39e-10 Aortic root size; CRC cis rs4713118 0.666 rs2893930 chr6:27738806 T/C cg20933634 chr6:27740509 NA 0.63 7.31 0.37 2.09e-12 Parkinson's disease; CRC trans rs208515 0.525 rs4145045 chr6:66678949 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.9 11.4 0.53 1.3e-25 Exhaled nitric oxide levels; CRC cis rs67340775 0.541 rs200975 chr6:27855625 G/T cg12273811 chr6:28175739 NA 0.58 5.98 0.31 5.69e-9 Lung cancer in ever smokers; CRC cis rs2075371 1.000 rs2505 chr7:133979552 C/T cg02659138 chr7:134003124 SLC35B4 0.4 6.94 0.36 2.16e-11 Mean platelet volume; CRC cis rs1448094 0.817 rs7972773 chr12:86340774 A/C cg02569458 chr12:86230093 RASSF9 0.47 7.99 0.4 2.26e-14 Major depressive disorder; CRC cis rs9611565 0.694 rs5758411 chr22:42079734 G/A cg03806693 chr22:41940476 POLR3H 0.68 9.45 0.46 6.36e-19 Vitiligo; CRC trans rs8002861 0.692 rs9533646 chr13:44410669 T/C cg17145862 chr1:211918768 LPGAT1 -0.5 -8.21 -0.41 5.26e-15 Leprosy; CRC cis rs4308124 0.708 rs28871990 chr2:111962441 G/A cg04571233 chr2:111982156 NA -0.55 -8.2 -0.41 5.46e-15 Vitiligo; CRC cis rs4713118 0.824 rs7759217 chr6:27730463 A/G cg08798685 chr6:27730294 NA -0.49 -6.88 -0.35 3.11e-11 Parkinson's disease; CRC cis rs10504229 1.000 rs67388517 chr8:58176617 C/A cg22535103 chr8:58192502 C8orf71 -0.82 -12.27 -0.56 9.63e-29 Developmental language disorder (linguistic errors); CRC cis rs12144094 0.882 rs12127451 chr1:120227630 C/A cg20995928 chr1:120229863 NA 0.47 6.76 0.35 6.26e-11 Height; CRC cis rs6743376 0.556 rs2515392 chr2:113817181 C/T cg24553058 chr2:113831203 IL1F10 0.43 6.97 0.36 1.78e-11 Inflammatory biomarkers; CRC cis rs1799949 1.000 rs8176242 chr17:41217874 C/T cg25072359 chr17:41440525 NA 0.45 6.57 0.34 1.96e-10 Menopause (age at onset); CRC cis rs13118159 0.836 rs2293630 chr4:1342521 G/A cg02018176 chr4:1364513 KIAA1530 0.43 7.13 0.37 6.41e-12 Longevity; CRC cis rs2386661 0.591 rs11255051 chr10:5653450 A/G cg26603656 chr10:5671107 NA 0.48 8.31 0.42 2.63e-15 Breast cancer; CRC trans rs17685 0.753 rs4573217 chr7:75733946 G/A cg19862616 chr7:65841803 NCRNA00174 1.0 18.87 0.72 2.33e-54 Coffee consumption;Coffee consumption (cups per day); CRC cis rs1475911 0.671 rs12483409 chr21:43521902 G/A cg14562523 chr21:43528734 C21orf128;UMODL1 -0.63 -9.87 -0.48 2.64e-20 IgG glycosylation; CRC cis rs13256369 0.802 rs11249883 chr8:8561537 G/A cg06671706 chr8:8559999 CLDN23 0.61 9.04 0.45 1.35e-17 Obesity-related traits; CRC cis rs12220238 1.000 rs10824084 chr10:75911415 T/C cg19889307 chr10:75911429 ADK;AP3M1 0.64 6.42 0.33 4.71e-10 Soluble interleukin-2 receptor subunit alpha; CRC cis rs7762018 1.000 rs7746598 chr6:170084933 T/A cg24289452 chr6:170231220 NA -0.59 -6.42 -0.33 4.75e-10 Thiazide-induced adverse metabolic effects in hypertensive patients; CRC cis rs4665809 1.000 rs6729757 chr2:26285102 A/G cg04944784 chr2:26401820 FAM59B -0.6 -7.7 -0.39 1.64e-13 Gut microbiome composition (summer); CRC cis rs713477 0.901 rs7146306 chr14:55905853 C/T cg13175173 chr14:55914753 NA -0.53 -9.94 -0.48 1.62e-20 Pediatric bone mineral content (femoral neck); CRC cis rs60843830 0.633 rs1078763 chr2:113763 A/G cg00108164 chr2:264199 ACP1;SH3YL1 -0.42 -6.18 -0.32 1.86e-9 Spherical equivalent (joint analysis main effects and education interaction); CRC trans rs7580658 0.614 rs7585198 chr2:127962635 C/T cg19027507 chr1:27320128 TRNP1 -0.44 -5.98 -0.31 5.75e-9 Protein C levels; CRC cis rs8103278 1.000 rs9807819 chr19:46239598 C/T cg20908204 chr19:46285434 DMPK -0.4 -8.18 -0.41 6.29e-15 Coronary artery disease; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg24023618 chr6:114292459 HDAC2 0.48 6.28 0.33 1.09e-9 Thyroid stimulating hormone; CRC cis rs9611519 0.964 rs2179744 chr22:41621714 G/A cg03806693 chr22:41940476 POLR3H -0.48 -6.21 -0.32 1.6e-9 Neuroticism; CRC cis rs10504229 1.000 rs949848 chr8:58169125 A/G cg22535103 chr8:58192502 C8orf71 -0.79 -12.19 -0.56 1.84e-28 Developmental language disorder (linguistic errors); CRC cis rs7412746 0.658 rs12410394 chr1:150860186 G/A cg10589385 chr1:150898437 SETDB1 0.33 6.95 0.36 1.92e-11 Melanoma; CRC cis rs9487051 0.872 rs1111863 chr6:109611206 C/T cg01475377 chr6:109611718 NA 0.48 8.87 0.44 4.72e-17 Reticulocyte fraction of red cells; CRC cis rs597539 0.652 rs654071 chr11:68653432 A/C cg04772025 chr11:68637568 NA 0.48 7.36 0.38 1.51e-12 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs28655083 1.000 rs1843455 chr16:77072343 G/A cg01753188 chr16:77233325 SYCE1L;MON1B -0.54 -7.71 -0.39 1.51e-13 Lobe attachment (rater-scored or self-reported); CRC cis rs1580019 0.961 rs6949851 chr7:32493807 T/G cg07520158 chr7:32535189 LSM5;AVL9 0.46 6.48 0.34 3.32e-10 Cognitive ability; CRC cis rs7552404 0.883 rs77773255 chr1:76217193 G/A cg10523679 chr1:76189770 ACADM 0.85 11.74 0.54 8.12e-27 Blood metabolite levels;Acylcarnitine levels; CRC cis rs123509 0.687 rs17238972 chr3:42819975 C/G cg12982090 chr3:42733453 KBTBD5 -0.56 -6.82 -0.35 4.36e-11 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC trans rs13046373 0.905 rs4816372 chr21:32077414 A/T cg01932125 chr11:77377926 RSF1 -0.39 -6.28 -0.33 1.08e-9 HDL cholesterol; CRC cis rs10944 0.598 rs595479 chr5:78275651 G/C cg13121490 chr5:78280331 ARSB -0.45 -6.57 -0.34 1.99e-10 Blood and toenail selenium levels; CRC cis rs4930561 0.677 rs7946212 chr11:67982187 T/A cg04465784 chr11:67976953 SUV420H1 -0.3 -6.05 -0.32 3.88e-9 Breast cancer in childhood cancer survivors;IgG glycosylation; CRC cis rs11249608 0.636 rs6888567 chr5:178449074 C/T cg01312482 chr5:178451176 ZNF879 0.34 5.77 0.3 1.88e-8 Pubertal anthropometrics; CRC cis rs4253772 0.591 rs6007727 chr22:46650959 G/A cg24881330 chr22:46731750 TRMU 0.56 6.6 0.34 1.61e-10 LDL cholesterol;Cholesterol, total; CRC cis rs2011503 1.000 rs2905422 chr19:19460703 A/G cg11584989 chr19:19387371 SF4 -0.56 -5.98 -0.31 5.88e-9 Bipolar disorder; CRC cis rs875971 0.660 rs801192 chr7:66031952 C/G cg11764359 chr7:65958608 NA -0.55 -8.63 -0.43 2.66e-16 Aortic root size; CRC cis rs9787249 0.957 rs2274949 chr1:40221067 G/A cg24920358 chr1:40204285 PPIE 0.59 9.03 0.45 1.53e-17 Blood protein levels; CRC cis rs2153535 0.541 rs6923558 chr6:8461467 T/G cg21535247 chr6:8435926 SLC35B3 0.49 7.43 0.38 9.44e-13 Motion sickness; CRC cis rs2153535 0.580 rs6597318 chr6:8437289 G/A cg07606381 chr6:8435919 SLC35B3 0.66 10.72 0.51 3.32e-23 Motion sickness; CRC cis rs11212617 0.905 rs3901851 chr11:108352335 G/A cg01991180 chr11:108092276 ATM;NPAT 0.39 5.7 0.3 2.62e-8 Response to metformin in type 2 diabetes (glycemic); CRC cis rs17376456 0.825 rs10052662 chr5:93271385 A/G cg21475434 chr5:93447410 FAM172A 0.82 7.84 0.4 6.37e-14 Diabetic retinopathy; CRC cis rs6840360 0.967 rs10028961 chr4:152668224 A/G cg09659197 chr4:152720779 NA 0.51 11.24 0.53 4.96e-25 Intelligence (multi-trait analysis); CRC cis rs801193 0.761 rs2659888 chr7:66230171 T/G cg25985355 chr7:65971099 NA -0.32 -5.62 -0.3 4.12e-8 Aortic root size; CRC trans rs10858396 1.000 rs7042225 chr9:138274938 C/T cg26979339 chr12:107168153 RIC8B 0.47 6.13 0.32 2.53e-9 Attention deficit hyperactivity disorder; CRC cis rs9660180 0.935 rs2180311 chr1:1748734 T/C cg05132306 chr1:1846340 CALML6 -0.46 -7.18 -0.37 4.58e-12 Body mass index; CRC cis rs7590720 0.819 rs1344694 chr2:216893637 T/G cg25588852 chr2:216877276 MREG -0.33 -6.19 -0.32 1.8e-9 Alcohol dependence; CRC cis rs7312933 0.501 rs7296357 chr12:42729891 T/G cg11827402 chr12:42719852 PPHLN1;ZCRB1 -0.65 -9.52 -0.46 3.99e-19 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CRC cis rs6709815 0.841 rs6740004 chr2:219663153 G/A cg02176678 chr2:219576539 TTLL4 -0.4 -6.48 -0.34 3.28e-10 Reticulocyte count;High light scatter reticulocyte count; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg14108394 chr12:62997291 MIRLET7I;C12orf61 0.44 6.24 0.33 1.38e-9 Anxiety disorder; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg19223274 chr6:143381998 AIG1 -0.41 -6.18 -0.32 1.87e-9 Myopia (pathological); CRC cis rs7552404 1.000 rs11163924 chr1:76132070 A/C cg03433033 chr1:76189801 ACADM -0.81 -11.1 -0.52 1.53e-24 Blood metabolite levels;Acylcarnitine levels; CRC cis rs2239547 0.618 rs1573815 chr3:52870132 A/G cg18404041 chr3:52824283 ITIH1 0.41 7.55 0.38 4.38e-13 Schizophrenia; CRC cis rs780094 0.564 rs4665978 chr2:27648726 T/C cg24768116 chr2:27665128 KRTCAP3 -0.34 -7.74 -0.39 1.21e-13 Calcium levels;Fasting blood insulin;Metabolic traits;Triglyceride levels;Fasting plasma glucose;Urate levels in overweight individuals;Urate levels in obese individuals;Uric acid levels;Height;Age-related diseases, mortality and associated endophenotypes;Renal underexcretion gout;Fasting blood glucose (BMI interaction);Urate levels;Gondoic acid (20:1n-9) levels;Fasting blood insulin (BMI interaction);Triglycerides;Plasma omega-3 polyunsaturated fatty acid levels (docosapentaenoic acid);Type 2 diabetes;Nonalcoholic fatty liver disease;Hypertriglyceridemia;C-reactive protein;Age-related disease endophenotypes;LDL cholesterol;Metabolic syndrome;Crohn's disease;Alcohol consumption (drinks per week);Homeostasis model assessment of insulin resistance;Alcohol consumption;Red blood cell count;Fasting blood glucose; CRC cis rs2304069 0.614 rs216140 chr5:149443298 C/T cg22760475 chr5:149380129 HMGXB3;TIGD6 0.5 7.25 0.37 2.91e-12 HIV-1 control; CRC cis rs727563 0.635 rs5751141 chr22:42107745 A/G cg06481639 chr22:41940642 POLR3H 0.52 5.72 0.3 2.36e-8 Crohn's disease;Inflammatory bowel disease; CRC cis rs7119 0.604 rs2667781 chr15:77858619 A/C cg27398640 chr15:77910606 LINGO1 0.46 7.8 0.39 8.41e-14 Type 2 diabetes; CRC cis rs7762018 0.655 rs11966349 chr6:170162537 A/G cg24289452 chr6:170231220 NA 0.62 6.43 0.33 4.56e-10 Thiazide-induced adverse metabolic effects in hypertensive patients; CRC cis rs208520 0.690 rs12192851 chr6:66705862 G/C cg07460842 chr6:66804631 NA 1.04 14.64 0.63 1.04e-37 Exhaled nitric oxide output; CRC cis rs2952156 0.959 rs2934952 chr17:37832366 G/A cg20243544 chr17:37824526 PNMT 0.54 8.41 0.42 1.28e-15 Asthma; CRC cis rs17666538 0.792 rs1703912 chr8:600643 A/G cg02524346 chr8:600233 NA 0.98 9.41 0.46 8.55e-19 IgG glycosylation; CRC cis rs4974559 0.895 rs10018133 chr4:1338246 C/T cg02980000 chr4:1222292 CTBP1 0.75 8.54 0.43 5.16e-16 Systolic blood pressure; CRC cis rs17401966 0.838 rs11579365 chr1:10470846 G/T cg19773385 chr1:10388646 KIF1B -0.65 -10.34 -0.5 7.08e-22 Hepatocellular carcinoma; CRC cis rs7666738 0.791 rs4699324 chr4:98967496 G/A cg17366294 chr4:99064904 C4orf37 0.42 7.21 0.37 3.87e-12 Colonoscopy-negative controls vs population controls; CRC cis rs8180040 0.764 rs12629262 chr3:47196580 C/T cg10298567 chr3:47292165 KIF9 -0.36 -5.77 -0.3 1.8e-8 Colorectal cancer; CRC cis rs10504229 0.679 rs11781858 chr8:58038406 C/T cg20607798 chr8:58055168 NA 0.49 5.61 0.3 4.23e-8 Developmental language disorder (linguistic errors); CRC trans rs10202249 0.716 rs80164862 chr2:154073086 G/A cg25823578 chr14:52781312 PTGER2 -0.59 -6.08 -0.32 3.32e-9 Conotruncal heart defects (inherited effects); CRC cis rs9733 0.596 rs12089731 chr1:150647798 T/C cg18016565 chr1:150552671 MCL1 0.46 6.74 0.35 6.91e-11 Tonsillectomy; CRC cis rs12477438 0.798 rs6542848 chr2:99573732 T/C cg14399236 chr2:99771627 LIPT1;TSGA10 -0.7 -9.73 -0.47 8.17e-20 Chronic sinus infection; CRC cis rs6502050 0.865 rs8073679 chr17:80155343 G/A cg02741985 chr17:80059408 CCDC57 0.45 7.27 0.37 2.71e-12 Life satisfaction; CRC cis rs41271951 0.512 rs11204774 chr1:151062957 C/T cg11822372 chr1:151115635 SEMA6C -0.71 -5.74 -0.3 2.15e-8 Blood protein levels; CRC cis rs6502050 0.835 rs62078304 chr17:80085224 G/A cg19223190 chr17:80058835 NA -0.39 -6.22 -0.32 1.52e-9 Life satisfaction; CRC cis rs9329221 0.905 rs28712068 chr8:10251145 G/C cg27411982 chr8:10470053 RP1L1 -0.36 -5.8 -0.3 1.52e-8 Neuroticism; CRC cis rs4713118 0.869 rs9283881 chr6:27715255 A/T cg25164649 chr6:28176230 NA 0.59 8.32 0.42 2.36e-15 Parkinson's disease; CRC trans rs931812 0.895 rs4734493 chr8:101902169 C/T cg20993868 chr7:22813445 NA -0.5 -9.49 -0.46 5.01e-19 Attention deficit hyperactivity disorder and conduct disorder; CRC cis rs6479527 0.904 rs10761315 chr9:96875556 A/T cg14459158 chr9:96720562 NA 0.37 6.51 0.34 2.88e-10 Esophageal adenocarcinoma; CRC cis rs418053 0.648 rs204232 chr6:13659079 T/G cg02206980 chr6:13574034 SIRT5 -0.37 -6.1 -0.32 2.95e-9 Breast cancer; CRC cis rs6502050 0.805 rs4356529 chr17:80157797 A/G cg02741985 chr17:80059408 CCDC57 -0.41 -6.75 -0.35 6.69e-11 Life satisfaction; CRC cis rs8060686 0.545 rs12600062 chr16:68287544 C/A cg09835421 chr16:68378352 PRMT7 -0.61 -5.64 -0.3 3.73e-8 HDL cholesterol;Metabolic syndrome; CRC cis rs4285028 0.948 rs7615571 chr3:121665950 A/C cg11130432 chr3:121712080 ILDR1 -0.51 -6.65 -0.34 1.23e-10 Multiple sclerosis; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg21819024 chr1:52344978 NRD1 0.44 6.26 0.33 1.19e-9 Response to antipsychotic treatment; CRC cis rs13108904 0.967 rs4428235 chr4:1278891 C/T cg16405210 chr4:1374714 KIAA1530 -0.46 -6.29 -0.33 1.04e-9 Obesity-related traits; CRC cis rs12477438 0.520 rs11692699 chr2:99730657 T/C cg14399236 chr2:99771627 LIPT1;TSGA10 0.82 14.43 0.62 6.62e-37 Chronic sinus infection; CRC cis rs2952156 1.000 rs2088126 chr17:37879030 A/G cg20243544 chr17:37824526 PNMT 0.53 7.94 0.4 3.24e-14 Asthma; CRC cis rs736408 0.540 rs4687637 chr3:52634092 C/T cg18099408 chr3:52552593 STAB1 -0.48 -8.23 -0.41 4.49e-15 Bipolar disorder; CRC cis rs7584330 0.657 rs10190310 chr2:238352282 C/T cg16989719 chr2:238392110 NA -0.44 -8.0 -0.4 2.11e-14 Prostate cancer; CRC cis rs7659604 0.791 rs57316471 chr4:122663939 A/G cg19748678 chr4:122722346 EXOSC9 0.61 9.91 0.48 2e-20 Type 2 diabetes; CRC cis rs4969178 0.965 rs11653305 chr17:76386918 T/C cg20026190 chr17:76395443 PGS1 0.39 5.96 0.31 6.48e-9 HDL cholesterol levels; CRC cis rs7945705 0.791 rs6484484 chr11:8817206 A/G cg12365402 chr11:9010492 NRIP3 0.36 6.03 0.32 4.47e-9 Hemoglobin concentration; CRC cis rs9611565 0.918 rs9538 chr22:41755857 G/T cg06634786 chr22:41940651 POLR3H -0.6 -6.93 -0.36 2.19e-11 Vitiligo; CRC cis rs11628318 0.614 rs7149667 chr14:103129441 G/A cg08075719 chr14:103021372 NA 0.64 7.29 0.37 2.35e-12 Platelet count; CRC cis rs72615157 0.634 rs7789890 chr7:99800559 G/T cg07160278 chr7:100027354 MEPCE;ZCWPW1 0.72 8.63 0.43 2.75e-16 Lung function (FEV1/FVC); CRC cis rs12188164 1.000 rs56042615 chr5:437667 G/A cg16322479 chr5:444228 EXOC3;C5orf55 0.48 7.84 0.4 6.19e-14 Cystic fibrosis severity; CRC cis rs7089973 0.604 rs17663387 chr10:116588060 C/G cg23260525 chr10:116636907 FAM160B1 0.39 9.25 0.45 3.02e-18 Bipolar disorder or attention deficit hyperactivity disorder; CRC cis rs2836633 0.929 rs8130434 chr21:40036243 C/T cg05519781 chr21:40033154 ERG -0.66 -12.98 -0.58 2.16e-31 Coronary artery disease; CRC cis rs344364 0.511 rs2917519 chr16:1950479 C/A cg03013636 chr16:1946785 NA 0.58 7.09 0.36 8.32e-12 Glomerular filtration rate in chronic kidney disease; CRC cis rs561341 0.883 rs4450460 chr17:30201309 C/T cg13647721 chr17:30228624 UTP6 -0.56 -5.75 -0.3 2.09e-8 Hip circumference adjusted for BMI; CRC cis rs9287719 0.649 rs2024432 chr2:10731474 C/T cg00105475 chr2:10696890 NA 0.44 7.0 0.36 1.43e-11 Prostate cancer; CRC cis rs514406 0.505 rs6703127 chr1:53180565 C/T cg08859206 chr1:53392774 SCP2 -0.4 -5.98 -0.31 5.82e-9 Monocyte count; CRC cis rs12681288 0.862 rs2004701 chr8:1022287 A/G cg15309053 chr8:964076 NA 0.4 7.3 0.37 2.23e-12 Schizophrenia; CRC cis rs1707322 1.000 rs12077974 chr1:46384141 G/A cg03146154 chr1:46216737 IPP 0.47 6.27 0.33 1.11e-9 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs2204008 0.623 rs1315348 chr12:38163044 G/A cg26384229 chr12:38710491 ALG10B -0.56 -8.36 -0.42 1.75e-15 Bladder cancer; CRC cis rs1008375 1.000 rs56308330 chr4:17643050 G/A cg02297831 chr4:17616191 MED28 0.42 5.6 0.3 4.43e-8 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs2243480 1.000 rs316331 chr7:65604622 A/G cg12463550 chr7:65579703 CRCP -0.68 -6.31 -0.33 9.18e-10 Diabetic kidney disease; CRC cis rs2617583 0.509 rs13089 chr5:1462732 G/C cg07148919 chr5:1466943 LPCAT1 -0.44 -5.75 -0.3 2.05e-8 Breast cancer; CRC cis rs1448094 0.512 rs7960130 chr12:86243191 T/C cg19622623 chr12:86230825 RASSF9 -0.41 -6.7 -0.35 9.04e-11 Major depressive disorder; CRC cis rs9341808 0.718 rs1324123 chr6:80932894 G/A cg08355045 chr6:80787529 NA 0.43 6.83 0.35 4.15e-11 Sitting height ratio; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg15645079 chr20:3140569 FASTKD5;UBOX5 0.47 6.03 0.32 4.44e-9 Thyroid stimulating hormone; CRC cis rs7762018 0.607 rs7759404 chr6:170135728 A/G cg24289452 chr6:170231220 NA -0.57 -6.39 -0.33 5.75e-10 Thiazide-induced adverse metabolic effects in hypertensive patients; CRC cis rs4927850 1.000 rs4927850 chr3:195751630 C/T cg00031303 chr3:195681400 NA -0.48 -6.8 -0.35 4.81e-11 Pancreatic cancer; CRC cis rs6424115 0.708 rs12748109 chr1:24181177 C/T cg10978503 chr1:24200527 CNR2 -0.43 -6.72 -0.35 8.18e-11 Immature fraction of reticulocytes; CRC cis rs7937682 0.883 rs510388 chr11:111451869 G/T cg19812747 chr11:111475976 SIK2 0.53 9.18 0.45 5.01e-18 Primary sclerosing cholangitis; CRC trans rs1005277 0.579 rs2008449 chr10:38414204 A/T cg23533926 chr12:111358616 MYL2 0.53 8.2 0.41 5.47e-15 Extrinsic epigenetic age acceleration; CRC trans rs2228479 0.850 rs17226512 chr16:89839976 T/C cg24644049 chr4:85504048 CDS1 0.9 7.57 0.39 3.72e-13 Skin colour saturation; CRC cis rs10504229 0.775 rs55825382 chr8:58157605 G/A cg02725872 chr8:58115012 NA -0.58 -9.06 -0.45 1.21e-17 Developmental language disorder (linguistic errors); CRC cis rs1046896 0.553 rs2292965 chr17:80900645 G/A cg17346650 chr17:80929145 B3GNTL1 0.48 7.08 0.36 8.88e-12 Glycated hemoglobin levels; CRC cis rs539096 0.692 rs7549094 chr1:44213178 C/A cg12908607 chr1:44402522 ARTN -0.35 -6.04 -0.32 4.14e-9 Intelligence (multi-trait analysis); CRC cis rs8072100 0.817 rs9892497 chr17:45545919 G/A cg08085267 chr17:45401833 C17orf57 -0.62 -9.91 -0.48 1.95e-20 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs3736594 0.513 rs60854669 chr2:27786929 T/C cg27432699 chr2:27873401 GPN1 0.64 8.39 0.42 1.42e-15 Fasting blood glucose;Fasting blood glucose (BMI interaction); CRC cis rs1223397 0.617 rs957176 chr6:13311526 C/T cg07912922 chr6:13274314 PHACTR1 0.38 6.01 0.31 4.81e-9 Blood pressure; CRC cis rs9468199 1.000 rs9468199 chr6:27681215 G/A cg06470822 chr6:28175283 NA 0.51 6.24 0.33 1.34e-9 Parkinson's disease; CRC trans rs867371 0.502 rs1846908 chr15:82522526 T/C cg04831495 chr15:85060580 GOLGA6L5 -0.38 -6.14 -0.32 2.35e-9 Cognitive ability;Cognitive ability (multi-trait analysis); CRC cis rs17209837 0.607 rs4148810 chr7:87102251 C/T cg00919237 chr7:87102261 ABCB4 -0.55 -7.21 -0.37 3.94e-12 Gallbladder cancer; CRC cis rs7615952 0.641 rs2365019 chr3:125808135 T/C cg18479299 chr3:125709523 NA -0.56 -6.6 -0.34 1.6e-10 Blood pressure (smoking interaction); CRC cis rs6724607 1.000 rs28452331 chr2:191471847 C/T cg27211696 chr2:191398769 TMEM194B -0.42 -6.25 -0.33 1.27e-9 Pulse pressure; CRC cis rs796364 1.000 rs281783 chr2:200751582 G/A cg23649088 chr2:200775458 C2orf69 0.54 5.98 0.31 5.68e-9 Schizophrenia; CRC cis rs9527 0.590 rs7906754 chr10:104782557 T/C cg04362960 chr10:104952993 NT5C2 0.6 8.48 0.42 7.93e-16 Arsenic metabolism; CRC cis rs2115630 0.875 rs8039472 chr15:85361644 A/G cg12501888 chr15:85177176 SCAND2 -0.38 -6.12 -0.32 2.66e-9 P wave terminal force; CRC cis rs67311347 0.577 rs11712626 chr3:40259927 G/A cg09455208 chr3:40491958 NA 0.32 6.58 0.34 1.89e-10 Renal cell carcinoma; CRC cis rs2797160 1.000 rs6569435 chr6:125998186 T/C cg05901451 chr6:126070800 HEY2 -0.39 -5.99 -0.31 5.38e-9 Endometrial cancer; CRC cis rs12048904 0.595 rs2295280 chr1:101342497 T/C cg15686842 chr1:101360669 SLC30A7;EXTL2 0.49 6.72 0.35 8.1e-11 Multiple sclerosis; CRC cis rs2976388 0.590 rs13254346 chr8:143823863 G/C cg20041105 chr8:143859282 LYNX1 -0.41 -6.78 -0.35 5.42e-11 Urinary tract infection frequency; CRC cis rs4665809 0.816 rs2384359 chr2:26371364 T/C cg27170947 chr2:26402098 FAM59B -0.5 -5.97 -0.31 6.14e-9 Gut microbiome composition (summer); CRC cis rs780096 0.526 rs13391837 chr2:27649375 A/G cg21248554 chr2:27665150 KRTCAP3 -0.32 -7.39 -0.38 1.2e-12 Total body bone mineral density; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg08555160 chr16:69166339 CHTF8;CIRH1A 0.37 6.17 0.32 1.99e-9 Liver disease severity in Alagille syndrome; CRC cis rs9303401 0.659 rs17741087 chr17:56550300 C/T cg10487724 chr17:56770010 TEX14;RAD51C 0.77 9.53 0.47 3.55e-19 Cognitive test performance; CRC cis rs61990749 0.686 rs11159288 chr14:78216972 G/A cg23188588 chr14:78226832 SNW1;C14orf178 0.57 5.72 0.3 2.38e-8 Fibroblast growth factor basic levels; CRC cis rs12802200 0.561 rs746707 chr11:571984 C/T cg01842473 chr11:617407 IRF7;MUPCDH -0.49 -6.48 -0.34 3.42e-10 Systemic lupus erythematosus; CRC cis rs6076065 0.707 rs2024746 chr20:23356862 G/A cg11657817 chr20:23433608 CST11 0.55 9.54 0.47 3.41e-19 Facial morphology (factor 15, philtrum width); CRC cis rs7618915 0.501 rs7622694 chr3:52663882 G/A cg15147215 chr3:52552868 STAB1 -0.64 -11.05 -0.52 2.42e-24 Bipolar disorder; CRC cis rs6788895 0.661 rs73010947 chr3:150485742 T/C cg09723797 chr3:150481914 SIAH2 0.88 6.51 0.34 2.75e-10 Breast cancer; CRC cis rs951366 1.000 rs951366 chr1:205685352 C/T cg14893161 chr1:205819251 PM20D1 0.41 5.89 0.31 9.68e-9 Menarche (age at onset); CRC cis rs6912958 0.500 rs9342104 chr6:87798512 A/G cg08069147 chr6:88032118 GJB7;C6orf162 -0.59 -8.53 -0.43 5.54e-16 Monocyte percentage of white cells; CRC cis rs67478160 0.634 rs2368559 chr14:104230535 C/T cg01849466 chr14:104193079 ZFYVE21 -0.56 -10.47 -0.5 2.58e-22 Schizophrenia; CRC cis rs7618915 0.501 rs7611731 chr3:52692721 T/C cg18099408 chr3:52552593 STAB1 -0.47 -8.01 -0.4 2.01e-14 Bipolar disorder; CRC cis rs9311474 0.607 rs4475032 chr3:52560021 C/T cg18404041 chr3:52824283 ITIH1 -0.35 -7.13 -0.37 6.56e-12 Electroencephalogram traits; CRC cis rs2836974 0.568 rs2183573 chr21:40574305 A/G cg11644478 chr21:40555479 PSMG1 -0.7 -11.47 -0.53 7.57e-26 Cognitive function; CRC cis rs7558233 0.614 rs59454437 chr2:23682476 A/G cg00747342 chr2:23700632 KLHL29 0.52 5.62 0.3 4.05e-8 Cannabis use (initiation); CRC cis rs798554 0.679 rs2533870 chr7:2885274 C/G cg19346786 chr7:2764209 NA 0.39 6.71 0.35 8.28e-11 Height; CRC cis rs13118159 0.934 rs4974608 chr4:1356780 C/T cg21620606 chr4:1342894 KIAA1530 0.37 6.51 0.34 2.82e-10 Longevity; CRC cis rs13064411 0.518 rs1552433 chr3:113225730 C/A cg18753928 chr3:113234510 CCDC52 -0.49 -7.75 -0.39 1.13e-13 Response to simvastatin treatment (PCSK9 protein level change); CRC cis rs4319547 0.774 rs10773394 chr12:123124778 C/A cg23029597 chr12:123009494 RSRC2 -0.43 -5.89 -0.31 9.77e-9 Body mass index; CRC cis rs6951245 0.554 rs10246354 chr7:1132456 C/T cg07217954 chr7:1067459 C7orf50 0.49 5.7 0.3 2.66e-8 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs7772486 0.875 rs2777476 chr6:146345024 A/G cg23711669 chr6:146136114 FBXO30 0.67 11.66 0.54 1.58e-26 Lobe attachment (rater-scored or self-reported); CRC cis rs2180341 1.000 rs6904520 chr6:127629802 T/C cg27446573 chr6:127587934 RNF146 0.99 14.65 0.63 8.94e-38 Breast cancer; CRC cis rs854765 0.624 rs9899634 chr17:17727943 A/T cg24612305 chr17:17875800 TOM1L2;LRRC48 -0.52 -8.06 -0.41 1.4e-14 Total body bone mineral density; CRC cis rs4713118 0.629 rs172165 chr6:28020814 T/G cg15845792 chr6:28175446 NA 0.9 13.11 0.59 6.83e-32 Parkinson's disease; CRC cis rs477895 0.713 rs11600867 chr11:63972052 T/A cg05016508 chr11:63871570 FLRT1;MACROD1 0.55 6.9 0.36 2.7e-11 Mean platelet volume; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg02853990 chr9:115480539 C9orf80 0.54 7.52 0.38 5.33e-13 Response to antipsychotic treatment; CRC cis rs501120 0.584 rs11511571 chr10:44727167 T/C cg09554077 chr10:44749378 NA 0.65 7.32 0.37 1.9e-12 Coronary artery disease;Coronary heart disease; CRC cis rs503341 0.756 rs10897450 chr11:63593219 G/C cg04362095 chr11:63592001 C11orf84 -0.56 -8.9 -0.44 3.79e-17 Pulse pressure; CRC trans rs6550704 0.687 rs9865314 chr3:22634337 A/G cg01735101 chr19:19774554 ATP13A1 -0.42 -6.22 -0.32 1.49e-9 Daytime sleep phenotypes; CRC cis rs910316 1.000 rs7145159 chr14:75583268 A/G cg11812906 chr14:75593930 NEK9 0.62 10.0 0.48 9.78e-21 Height; CRC cis rs6500602 0.627 rs934929 chr16:4587789 A/G cg06139259 chr16:4526053 HMOX2;NMRAL1 -0.44 -6.06 -0.32 3.83e-9 Schizophrenia; CRC cis rs959260 0.588 rs9894003 chr17:73405860 T/G cg14668889 chr17:73230827 NUP85 -0.49 -5.62 -0.3 4.14e-8 Systemic lupus erythematosus; CRC cis rs9902453 0.765 rs2628180 chr17:28101723 A/G cg26525008 chr17:28256777 EFCAB5;SSH2 -0.72 -12.11 -0.56 3.76e-28 Coffee consumption (cups per day); CRC cis rs12477438 0.765 rs9710648 chr2:99673129 A/C cg26064155 chr2:99771622 LIPT1;TSGA10 -0.63 -8.55 -0.43 4.61e-16 Chronic sinus infection; CRC trans rs9747201 0.862 rs11651738 chr17:80178691 A/T cg07393940 chr7:158741817 NA 0.52 7.31 0.37 2e-12 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs6582630 0.555 rs7305352 chr12:38473800 T/C cg13010199 chr12:38710504 ALG10B 0.47 5.99 0.31 5.57e-9 Drug-induced liver injury (flucloxacillin); CRC cis rs7333181 1.000 rs34163870 chr13:112233682 G/C cg27543320 chr13:112200689 NA 0.5 6.45 0.33 4.03e-10 Menopause (age at onset); CRC cis rs889398 0.616 rs35808754 chr16:69771710 G/T cg00738113 chr16:70207722 CLEC18C 0.37 6.13 0.32 2.46e-9 Body mass index; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg23200371 chr12:56367680 RAB5B 0.37 6.09 0.32 3.23e-9 Liver disease severity in Alagille syndrome; CRC trans rs853679 0.824 rs1321505 chr6:28052823 A/C cg06606381 chr12:133084897 FBRSL1 -0.95 -8.06 -0.41 1.38e-14 Depression; CRC cis rs2153535 0.526 rs9406179 chr6:8538224 G/A cg21535247 chr6:8435926 SLC35B3 0.49 7.59 0.39 3.34e-13 Motion sickness; CRC trans rs1005277 0.579 rs2474595 chr10:38426782 C/G cg27523141 chr10:43048294 ZNF37B -0.49 -7.07 -0.36 9.18e-12 Extrinsic epigenetic age acceleration; CRC cis rs2797160 1.000 rs1739349 chr6:126014984 G/C cg05901451 chr6:126070800 HEY2 0.39 6.06 0.32 3.66e-9 Endometrial cancer; CRC cis rs2749592 0.550 rs7081464 chr10:37883937 C/T cg00409905 chr10:38381863 ZNF37A 0.58 9.3 0.46 2.07e-18 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs763121 0.853 rs2284073 chr22:39105948 T/C cg06022373 chr22:39101656 GTPBP1 0.81 13.46 0.6 3.27e-33 Menopause (age at onset); CRC cis rs1448094 0.512 rs2405632 chr12:86252456 A/G cg18827107 chr12:86230957 RASSF9 -0.44 -7.3 -0.37 2.12e-12 Major depressive disorder; CRC cis rs10788264 0.504 rs4751885 chr10:124020305 G/T cg05683857 chr10:124030795 BTBD16 0.32 5.82 0.31 1.41e-8 Total body bone mineral density; CRC cis rs16936870 0.543 rs16936790 chr8:71086468 C/T cg14232793 chr8:71155543 NCOA2 -0.46 -5.7 -0.3 2.65e-8 QT interval; CRC cis rs72615157 0.634 rs2272343 chr7:99778285 A/C cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.57 6.78 0.35 5.45e-11 Lung function (FEV1/FVC); CRC cis rs9372498 0.505 rs62422250 chr6:118990182 T/C cg01339444 chr6:118972232 C6orf204 0.58 6.1 0.32 2.96e-9 Diastolic blood pressure; CRC cis rs7246865 0.954 rs3745348 chr19:17212410 C/T cg19418318 chr19:17219073 MYO9B 0.51 8.7 0.43 1.66e-16 Reticulocyte fraction of red cells; CRC cis rs6938 0.534 rs1130741 chr15:75189930 A/G cg14664628 chr15:75095509 CSK -0.68 -10.91 -0.52 7.11e-24 Breast cancer; CRC cis rs1403694 0.695 rs10937266 chr3:186433075 G/A cg04611788 chr3:186434169 KNG1 -0.6 -8.83 -0.44 6.23e-17 Blood protein levels; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg03274021 chr8:130952480 FAM49B 0.45 6.43 0.33 4.57e-10 Response to antipsychotic treatment; CRC cis rs7091068 0.616 rs6583905 chr10:95504022 T/G cg20715218 chr10:95462985 C10orf4 0.54 5.71 0.3 2.46e-8 Urinary tract infection frequency; CRC cis rs28386778 0.901 rs2665855 chr17:61965143 A/G cg06601766 chr17:61851465 DDX42;CCDC47 0.46 6.09 0.32 3.24e-9 Prudent dietary pattern; CRC cis rs7224685 0.501 rs781847 chr17:3958194 G/A cg11204139 chr17:3907470 NA 0.77 14.57 0.63 1.88e-37 Type 2 diabetes; CRC cis rs10426930 0.607 rs858415 chr19:5055996 C/T cg18473234 chr19:5097819 KDM4B -0.5 -6.29 -0.33 1.03e-9 Monocyte percentage of white cells; CRC cis rs1552244 1.000 rs68045038 chr3:10151828 A/G cg08888203 chr3:10149979 C3orf24 0.7 9.48 0.46 5.31e-19 Alzheimer's disease; CRC cis rs9733 0.565 rs11804276 chr1:150685761 T/A cg15448220 chr1:150897856 SETDB1 0.45 6.41 0.33 5.09e-10 Tonsillectomy; CRC cis rs9479482 0.789 rs12204988 chr6:150339315 T/G cg25797454 chr6:150327115 RAET1K 0.37 6.46 0.34 3.71e-10 Alopecia areata; CRC cis rs10905065 0.569 rs4750553 chr10:5728174 C/T cg11519256 chr10:5708881 ASB13 0.44 6.09 0.32 3.14e-9 Menopause (age at onset); CRC cis rs7786808 0.608 rs7784758 chr7:158214386 A/G cg15440763 chr7:158190612 PTPRN2 0.4 6.56 0.34 2.06e-10 Obesity-related traits; CRC cis rs2565722 0.583 rs2489945 chr6:161297724 A/G cg03159191 chr6:161285451 NA 0.39 6.0 0.31 5.08e-9 Blood protein levels; CRC cis rs514406 0.621 rs881198 chr1:53196440 C/T cg08859206 chr1:53392774 SCP2 0.43 6.75 0.35 6.84e-11 Monocyte count; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg26197690 chr5:139936946 SRA1 0.48 6.34 0.33 7.46e-10 Anxiety disorder; CRC cis rs995000 0.931 rs10493322 chr1:62905893 C/T cg19896129 chr1:63156450 NA 0.4 5.88 0.31 9.97e-9 Triglyceride levels; CRC cis rs8062405 1.000 rs62036657 chr16:28844365 G/A cg16576597 chr16:28551801 NUPR1 0.48 6.9 0.36 2.65e-11 Cognitive ability (multi-trait analysis);Cognitive ability; CRC trans rs1880529 0.830 rs3796929 chr4:114367980 A/G cg05422836 chr8:81806286 NA 0.42 6.11 0.32 2.82e-9 White matter integrity (bipolar disorder risk interaction); CRC cis rs13098911 0.540 rs13069742 chr3:46114216 A/G cg12691230 chr3:46064611 XCR1 -0.55 -6.03 -0.32 4.48e-9 Celiac disease; CRC cis rs2204008 0.527 rs1315367 chr12:38177487 G/T cg13010199 chr12:38710504 ALG10B -0.42 -6.08 -0.32 3.29e-9 Bladder cancer; CRC trans rs10982213 0.830 rs2274163 chr9:117188714 C/T cg24418792 chr10:104153828 NFKB2 0.39 6.47 0.34 3.6e-10 Interleukin-6 levels; CRC trans rs916888 0.773 rs199451 chr17:44801784 G/A cg10053473 chr17:62856997 LRRC37A3 -0.78 -8.65 -0.43 2.3e-16 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs7617773 0.832 rs6775114 chr3:48182620 G/C cg11946769 chr3:48343235 NME6 -0.47 -6.71 -0.35 8.55e-11 Coronary artery disease; CRC cis rs780096 0.526 rs4803 chr2:27667297 A/G cg24768116 chr2:27665128 KRTCAP3 -0.36 -8.22 -0.41 4.71e-15 Total body bone mineral density; CRC cis rs6933660 0.745 rs9371517 chr6:151739810 G/T cg14416726 chr6:151773293 C6orf211;RMND1 -0.57 -8.62 -0.43 2.9e-16 Menarche (age at onset); CRC cis rs989128 0.642 rs8076628 chr17:48626626 G/A cg16068336 chr17:48637367 CACNA1G -0.54 -7.73 -0.39 1.3e-13 Type 2 diabetes; CRC cis rs12079745 0.793 rs3766064 chr1:169157919 A/G cg09363564 chr1:169337483 NME7;BLZF1 0.92 6.02 0.32 4.55e-9 QT interval; CRC cis rs3858526 0.606 rs10838883 chr11:5952147 G/A cg13902645 chr11:5959945 NA 0.77 13.72 0.6 3.54e-34 DNA methylation (variation); CRC cis rs10504229 0.683 rs16921831 chr8:58111142 G/A cg21724239 chr8:58056113 NA 0.5 6.89 0.35 2.89e-11 Developmental language disorder (linguistic errors); CRC cis rs6952808 1.000 rs4719319 chr7:1888094 G/A cg22963979 chr7:1858916 MAD1L1 -0.66 -10.18 -0.49 2.43e-21 Bipolar disorder and schizophrenia; CRC cis rs6901250 0.851 rs339307 chr6:117177340 A/G cg12892004 chr6:117198278 RFX6 -0.42 -6.66 -0.34 1.16e-10 C-reactive protein levels; CRC cis rs9322817 0.691 rs4299867 chr6:105325383 G/C cg02098413 chr6:105308735 HACE1 0.43 8.49 0.42 7.27e-16 Thyroid stimulating hormone; CRC cis rs16852403 0.619 rs10798597 chr1:178108248 G/A cg00404053 chr1:178313656 RASAL2 0.6 7.63 0.39 2.56e-13 Childhood ear infection; CRC cis rs7613875 0.641 rs2624845 chr3:50062437 C/A cg24308560 chr3:49941425 MST1R 0.42 6.5 0.34 2.9e-10 Body mass index; CRC cis rs7727544 0.545 rs10074490 chr5:131340032 C/T cg02033258 chr5:131593261 PDLIM4 0.31 5.62 0.3 3.99e-8 Blood metabolite levels; CRC cis rs9818758 0.545 rs11717978 chr3:48969036 T/A cg07636037 chr3:49044803 WDR6 -0.83 -6.81 -0.35 4.67e-11 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; CRC cis rs2976388 0.578 rs34956412 chr8:143822028 C/T cg05569086 chr8:143859399 LYNX1 -0.39 -6.06 -0.32 3.81e-9 Urinary tract infection frequency; CRC cis rs514406 0.668 rs1672911 chr1:53340320 T/C cg25767906 chr1:53392781 SCP2 -0.53 -8.24 -0.41 4.01e-15 Monocyte count; CRC cis rs7811142 0.720 rs112622797 chr7:99917416 G/A cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.06 13.49 0.6 2.56e-33 Platelet count; CRC trans rs2832077 0.943 rs4816332 chr21:30201706 T/C cg14791747 chr16:20752902 THUMPD1 0.53 6.51 0.34 2.8e-10 Cognitive test performance; CRC cis rs10504229 0.683 rs2318148 chr8:58114955 G/A cg05313129 chr8:58192883 C8orf71 -0.43 -6.05 -0.32 4.04e-9 Developmental language disorder (linguistic errors); CRC cis rs1957429 0.901 rs3813422 chr14:65347404 G/A cg23373153 chr14:65346875 NA 0.79 8.25 0.41 3.9e-15 Pediatric areal bone mineral density (radius); CRC cis rs9649213 0.593 rs1468341 chr7:97987696 G/A cg24562669 chr7:97807699 LMTK2 0.44 7.29 0.37 2.39e-12 Prostate cancer (SNP x SNP interaction); CRC cis rs11764590 0.671 rs56226325 chr7:2078981 C/T cg02421172 chr7:1938701 MAD1L1 0.47 6.2 0.32 1.68e-9 Neuroticism; CRC cis rs7487075 0.930 rs7308910 chr12:46838242 T/C cg22049899 chr12:47219821 SLC38A4 0.31 6.25 0.33 1.3e-9 Itch intensity from mosquito bite; CRC cis rs9311474 0.659 rs1133415 chr3:52575831 G/A cg08222913 chr3:52553049 STAB1 -0.38 -7.35 -0.38 1.56e-12 Electroencephalogram traits; CRC cis rs3750082 0.889 rs6972006 chr7:32938292 T/C cg05721444 chr7:32995514 FKBP9 0.48 7.24 0.37 3.17e-12 Glomerular filtration rate (creatinine); CRC cis rs2742417 1.000 rs2742386 chr3:45756310 A/C cg04837898 chr3:45731254 SACM1L -0.35 -5.72 -0.3 2.4e-8 Response to anti-depressant treatment in major depressive disorder; CRC cis rs425277 0.606 rs424079 chr1:2071340 C/A cg21194808 chr1:2205498 SKI -0.4 -6.24 -0.33 1.36e-9 Height; CRC cis rs7666738 0.822 rs11097599 chr4:98959562 T/A cg05340658 chr4:99064831 C4orf37 0.61 9.54 0.47 3.45e-19 Colonoscopy-negative controls vs population controls; CRC cis rs4555082 0.957 rs2816608 chr14:105718407 A/G cg10792982 chr14:105748885 BRF1 -0.33 -5.96 -0.31 6.39e-9 Mean platelet volume;Platelet distribution width; CRC cis rs936229 0.784 rs12906946 chr15:75153140 A/G cg14664628 chr15:75095509 CSK -0.84 -14.54 -0.63 2.36e-37 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); CRC cis rs57221529 0.766 rs1399381 chr5:589853 G/T cg09021430 chr5:549028 NA -0.72 -7.85 -0.4 5.75e-14 Lung disease severity in cystic fibrosis; CRC cis rs7568458 0.846 rs6547621 chr2:85774676 G/A cg02493740 chr2:85810744 VAMP5 -0.38 -6.08 -0.32 3.28e-9 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); CRC cis rs4750440 0.523 rs4565800 chr10:14032326 G/C cg00551146 chr10:14014579 FRMD4A 0.45 7.25 0.37 2.99e-12 Adiponectin levels; CRC cis rs2302190 0.882 rs7210714 chr17:56675666 A/C cg12560992 chr17:57184187 TRIM37 0.52 6.13 0.32 2.48e-9 Vitamin D levels; CRC trans rs208520 0.690 rs10455595 chr6:66738034 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 1.05 14.83 0.63 1.81e-38 Exhaled nitric oxide output; CRC trans rs2727020 0.729 rs6485965 chr11:49166730 C/T cg03929089 chr4:120376271 NA 0.73 11.64 0.54 1.9e-26 Coronary artery disease; CRC trans rs7615952 0.543 rs4645102 chr3:125424441 A/G cg17147758 chr8:6949321 NA -0.53 -7.4 -0.38 1.14e-12 Blood pressure (smoking interaction); CRC cis rs11955398 0.521 rs4298206 chr5:60012235 T/C cg02684056 chr5:59996105 DEPDC1B -0.4 -5.81 -0.31 1.48e-8 Intelligence (multi-trait analysis); CRC cis rs6684514 1.000 rs66965793 chr1:156285814 G/A cg16558208 chr1:156270281 VHLL 0.58 8.92 0.44 3.2e-17 Mean corpuscular hemoglobin concentration;Glycated hemoglobin levels; CRC trans rs6430538 0.646 rs6734820 chr2:135536808 A/G cg12457986 chr21:27107982 ATP5J;GABPA 0.37 6.1 0.32 2.98e-9 Parkinson's disease; CRC cis rs3768617 1.000 rs2027077 chr1:183073453 G/C ch.1.3577855R chr1:183094577 LAMC1 0.62 9.34 0.46 1.51e-18 Fuchs's corneal dystrophy; CRC cis rs3754214 0.836 rs12023277 chr1:150466737 A/G cg15654264 chr1:150340011 RPRD2 0.4 5.91 0.31 8.38e-9 Cerebrospinal fluid biomarker levels; CRC cis rs9488822 0.676 rs10456902 chr6:116333742 C/G cg18764771 chr6:116381957 FRK -0.23 -6.59 -0.34 1.78e-10 Cholesterol, total;LDL cholesterol; CRC cis rs2579500 0.844 rs1866444 chr2:97172125 A/G cg23100626 chr2:96804247 ASTL -0.24 -5.85 -0.31 1.16e-8 Eosinophil counts;Eosinophil percentage of white cells; CRC cis rs35306767 0.903 rs11253475 chr10:907262 C/A cg20503657 chr10:835505 NA 0.93 11.91 0.55 1.96e-27 Eosinophil percentage of granulocytes; CRC cis rs3824867 0.920 rs7107853 chr11:47453518 T/C cg05585544 chr11:47624801 NA 0.41 6.32 0.33 8.5e-10 Mean corpuscular hemoglobin; CRC cis rs11229555 0.645 rs10896774 chr11:58175837 T/G cg15696309 chr11:58395628 NA -0.81 -10.45 -0.5 2.9e-22 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; CRC cis rs926938 0.527 rs360678 chr1:115493902 T/A cg12756093 chr1:115239321 AMPD1 0.48 6.96 0.36 1.85e-11 Autism; CRC cis rs1728785 0.688 rs7203363 chr16:68587692 T/A cg02972257 chr16:68554789 NA -0.61 -7.64 -0.39 2.46e-13 Ulcerative colitis; CRC cis rs4494114 0.967 rs1886748 chr1:39333775 C/A cg25970120 chr1:39325951 RRAGC -0.42 -5.62 -0.3 4.13e-8 Blood protein levels; CRC cis rs736408 0.609 rs13095332 chr3:52787242 C/T cg11645453 chr3:52864694 ITIH4 0.36 6.27 0.33 1.14e-9 Bipolar disorder; CRC trans rs4714291 0.832 rs2984431 chr6:39980900 T/A cg02267698 chr19:7991119 CTXN1 -0.49 -6.71 -0.35 8.33e-11 Strep throat; CRC cis rs8060686 0.920 rs2292316 chr16:67861134 C/G cg01951491 chr16:67709440 GFOD2 0.51 5.65 0.3 3.53e-8 HDL cholesterol;Metabolic syndrome; CRC cis rs10486722 0.606 rs4720405 chr7:41806349 A/G cg22138096 chr7:41772439 LOC285954 0.54 6.53 0.34 2.54e-10 Pit-and-Fissure caries; CRC cis rs10256972 0.706 rs12701970 chr7:1121958 T/C cg03188948 chr7:1209495 NA 0.43 6.04 0.32 4.12e-9 Longevity;Endometriosis; CRC cis rs9858542 0.953 rs7646366 chr3:49470668 G/A cg07274523 chr3:49395745 GPX1 0.48 6.55 0.34 2.2e-10 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs2066819 1.000 rs871130 chr12:56648777 A/G cg26714650 chr12:56694279 CS 1.32 11.07 0.52 1.96e-24 Psoriasis vulgaris; CRC cis rs9902453 0.900 rs9910970 chr17:28478329 C/G cg26525008 chr17:28256777 EFCAB5;SSH2 0.68 11.06 0.52 2.11e-24 Coffee consumption (cups per day); CRC cis rs13082711 0.911 rs13075550 chr3:27427618 A/G cg02860705 chr3:27208620 NA 0.62 8.83 0.44 6.36e-17 Systolic blood pressure;Diastolic blood pressure;Blood pressure; CRC cis rs2153535 0.601 rs9505451 chr6:8469950 C/T cg21535247 chr6:8435926 SLC35B3 0.49 7.4 0.38 1.14e-12 Motion sickness; CRC trans rs11098499 0.908 rs7695996 chr4:120322033 C/T cg25214090 chr10:38739885 LOC399744 0.65 10.41 0.5 4.16e-22 Corneal astigmatism; CRC cis rs728616 0.867 rs61859766 chr10:81683040 G/A cg05935833 chr10:81318306 SFTPA2 -0.72 -7.96 -0.4 2.77e-14 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs3825932 0.778 rs1036938 chr15:79237247 C/G cg25744700 chr15:79237217 CTSH 0.4 5.99 0.31 5.35e-9 Type 1 diabetes; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg22319682 chr19:11998584 ZNF69 0.5 7.36 0.38 1.51e-12 Intelligence (multi-trait analysis); CRC cis rs929354 0.772 rs4716460 chr7:156970054 T/C cg05182265 chr7:156933206 UBE3C -0.76 -14.38 -0.62 1.04e-36 Body mass index; CRC cis rs2841277 0.741 rs9672139 chr14:105408182 T/G cg15352829 chr14:105391018 PLD4 -0.52 -11.43 -0.53 1.08e-25 Rheumatoid arthritis; CRC cis rs9911578 1.000 rs11870671 chr17:56605360 A/G cg05425664 chr17:57184151 TRIM37 0.51 8.14 0.41 8.43e-15 Intelligence (multi-trait analysis); CRC cis rs13108904 0.870 rs13132584 chr4:1251504 G/T cg20092199 chr4:1342459 KIAA1530 0.34 5.9 0.31 8.88e-9 Obesity-related traits; CRC cis rs11122272 0.735 rs1076804 chr1:231498460 T/C cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.54 -8.13 -0.41 9.11e-15 Hemoglobin concentration; CRC cis rs6500602 0.701 rs11643057 chr16:4544505 C/T cg13763550 chr16:4524223 NMRAL1;HMOX2 0.42 5.73 0.3 2.22e-8 Schizophrenia; CRC cis rs243505 1.000 rs1019059 chr7:148424247 A/G cg09806900 chr7:148480153 CUL1 -0.44 -6.28 -0.33 1.04e-9 Inflammatory bowel disease;Crohn's disease; CRC cis rs6951245 0.872 rs76161580 chr7:1100307 G/T cg24642844 chr7:1081250 C7orf50 -0.76 -9.16 -0.45 5.78e-18 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs13064411 0.696 rs9869318 chr3:113146271 T/C cg18753928 chr3:113234510 CCDC52 -0.64 -8.73 -0.43 1.29e-16 Response to simvastatin treatment (PCSK9 protein level change); CRC cis rs4862750 0.914 rs6553026 chr4:187875648 C/T cg06074448 chr4:187884817 NA -0.59 -10.89 -0.51 8.5e-24 Lobe attachment (rater-scored or self-reported); CRC cis rs2404602 0.647 rs11629727 chr15:77009038 G/C cg23625390 chr15:77176239 SCAPER -0.84 -12.98 -0.58 2.21e-31 Blood metabolite levels; CRC cis rs7727544 0.606 rs11950562 chr5:131652529 A/C cg14196790 chr5:131705035 SLC22A5 0.37 6.35 0.33 7.24e-10 Blood metabolite levels; CRC cis rs798554 0.759 rs798495 chr7:2797267 T/C cg19346786 chr7:2764209 NA -0.44 -7.62 -0.39 2.72e-13 Height; CRC cis rs897984 0.762 rs7206511 chr16:30950352 G/A cg00531865 chr16:30841666 NA 0.49 6.86 0.35 3.47e-11 Dementia with Lewy bodies; CRC cis rs4862750 0.872 rs9998173 chr4:187898778 T/A cg27532560 chr4:187881888 NA -0.56 -10.24 -0.49 1.48e-21 Lobe attachment (rater-scored or self-reported); CRC cis rs62244186 0.566 rs55852922 chr3:44826188 A/G cg10263370 chr3:44754102 ZNF502 -0.36 -6.08 -0.32 3.31e-9 Depressive symptoms; CRC cis rs6973256 0.637 rs12707116 chr7:133424909 C/T cg10665199 chr7:133106180 EXOC4 -0.43 -6.73 -0.35 7.75e-11 Intelligence (multi-trait analysis); CRC cis rs999943 0.774 rs10947421 chr6:33611278 G/T cg14003231 chr6:33640908 ITPR3 0.91 16.62 0.68 1.87e-45 Obesity (extreme); CRC cis rs1005277 0.579 rs2505194 chr10:38393881 C/T cg17219203 chr10:38645113 HSD17B7P2 -0.42 -5.85 -0.31 1.22e-8 Extrinsic epigenetic age acceleration; CRC cis rs2882667 0.931 rs10074461 chr5:138319815 G/T cg04439458 chr5:138467593 SIL1 -0.31 -5.62 -0.3 4.16e-8 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs4731207 0.698 rs4731214 chr7:124442905 A/G cg23710748 chr7:124431027 NA 0.37 5.96 0.31 6.53e-9 Cutaneous malignant melanoma; CRC cis rs9649213 0.593 rs6465672 chr7:97963717 C/T cg24562669 chr7:97807699 LMTK2 -0.41 -6.87 -0.35 3.13e-11 Prostate cancer (SNP x SNP interaction); CRC cis rs875971 0.545 rs10950029 chr7:65634321 A/C cg11764359 chr7:65958608 NA 0.45 5.79 0.3 1.63e-8 Aortic root size; CRC cis rs9908102 0.740 rs58985615 chr17:12909988 C/A cg26162695 chr17:12921313 ELAC2 0.43 5.81 0.31 1.48e-8 Schizophrenia; CRC cis rs11649653 0.502 rs4889490 chr16:30823047 A/C cg02466173 chr16:30829666 NA -0.55 -7.77 -0.39 1.03e-13 Triglycerides; CRC cis rs1539053 0.966 rs11207081 chr1:58101851 A/C cg20292791 chr1:58089357 DAB1 -0.32 -5.64 -0.3 3.7e-8 Plasma omega-6 polyunsaturated fatty acid levels (arachidonic acid); CRC cis rs4400599 0.805 rs12063830 chr1:154150911 A/G cg05139571 chr1:154127138 NUP210L 0.42 6.27 0.33 1.12e-9 Platelet distribution width; CRC cis rs7605827 0.930 rs13001923 chr2:15521264 A/T cg19274914 chr2:15703543 NA 0.39 5.9 0.31 8.92e-9 Educational attainment (years of education); CRC cis rs60871478 1.000 rs62432861 chr7:807649 G/A cg13844804 chr7:814759 HEATR2 0.64 8.34 0.42 2.09e-15 Cerebrospinal P-tau181p levels; CRC cis rs1862618 0.671 rs2591961 chr5:56238597 A/G cg20203395 chr5:56204925 C5orf35 0.52 7.3 0.37 2.15e-12 Initial pursuit acceleration; CRC trans rs9858542 0.953 rs34588335 chr3:49407660 G/C cg21665057 chr3:196295764 WDR53;FBXO45 -0.64 -8.75 -0.43 1.1e-16 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs35306767 0.623 rs72760941 chr10:1141244 A/G cg26597838 chr10:835615 NA 0.67 7.75 0.39 1.16e-13 Eosinophil percentage of granulocytes; CRC cis rs5758659 0.652 rs133358 chr22:42442539 A/T cg04733989 chr22:42467013 NAGA 0.42 5.92 0.31 8.12e-9 Cognitive function; CRC cis rs8058578 1.000 rs67456513 chr16:30714828 A/T cg00531865 chr16:30841666 NA -0.45 -6.13 -0.32 2.58e-9 Multiple myeloma; CRC cis rs2274273 0.905 rs2075601 chr14:55609234 C/T cg23234261 chr14:55582407 NA -0.3 -5.91 -0.31 8.58e-9 Protein biomarker; CRC cis rs62408225 1.000 rs62408225 chr6:90956409 A/G cg06866423 chr6:90926672 BACH2 0.5 8.24 0.41 4.14e-15 Eosinophil counts;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC trans rs1656966 1.000 rs1656966 chr3:186466252 C/T cg15073462 chr3:172469117 NA 0.4 6.02 0.31 4.6e-9 Myopia (pathological); CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg10836402 chr12:31226622 DDX11 0.55 7.3 0.37 2.21e-12 Thyroid stimulating hormone; CRC cis rs4654899 0.758 rs1609558 chr1:21525228 C/T cg02927042 chr1:21476669 EIF4G3 0.42 6.52 0.34 2.7e-10 Superior frontal gyrus grey matter volume; CRC cis rs514406 0.505 rs437954 chr1:53173321 C/G cg24675658 chr1:53192096 ZYG11B -0.66 -10.25 -0.49 1.42e-21 Monocyte count; CRC cis rs1799949 1.000 rs11651341 chr17:41428061 T/C cg23758822 chr17:41437982 NA 0.79 13.42 0.59 4.56e-33 Menopause (age at onset); CRC cis rs9902453 0.845 rs7218113 chr17:28372130 A/G cg26525008 chr17:28256777 EFCAB5;SSH2 -0.69 -11.35 -0.53 2.01e-25 Coffee consumption (cups per day); CRC cis rs11190604 0.767 rs74869390 chr10:102189385 A/G cg07080220 chr10:102295463 HIF1AN 0.47 5.75 0.3 2.08e-8 Palmitoleic acid (16:1n-7) levels; CRC cis rs9914988 0.559 rs1109024 chr17:27189971 C/T cg20469991 chr17:27169893 C17orf63 0.47 5.91 0.31 8.55e-9 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs11585357 0.793 rs11588418 chr1:17616445 A/G cg08277548 chr1:17600880 PADI3 -0.89 -11.31 -0.53 2.94e-25 Hair shape; CRC cis rs644799 1.000 rs481630 chr11:95582447 G/C cg03916912 chr11:95522834 CEP57;FAM76B 0.95 18.31 0.71 3.77e-52 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs6460942 1.000 rs79964328 chr7:12319392 A/C cg20607287 chr7:12443886 VWDE -0.65 -6.43 -0.33 4.61e-10 Coronary artery disease; CRC cis rs478222 1.000 rs551573 chr2:25305504 A/G cg22495460 chr2:25135724 ADCY3 -0.4 -6.07 -0.32 3.44e-9 Type 1 diabetes; CRC cis rs7772486 0.686 rs9403741 chr6:146030548 G/A cg13319975 chr6:146136371 FBXO30 0.43 6.4 0.33 5.38e-10 Lobe attachment (rater-scored or self-reported); CRC cis rs12142240 0.698 rs41293273 chr1:46806393 T/C cg14993813 chr1:46806288 NSUN4 -0.5 -6.37 -0.33 6.42e-10 Menopause (age at onset); CRC cis rs780096 0.526 rs1260341 chr2:27663215 T/A cg22903471 chr2:27725779 GCKR -0.37 -6.05 -0.32 4.04e-9 Total body bone mineral density; CRC cis rs2857891 0.909 rs56026267 chr11:6940211 T/C cg02416716 chr11:6948024 ZNF215 0.57 5.86 0.31 1.14e-8 Response to cytadine analogues (cytosine arabinoside); CRC cis rs10870270 1.000 rs7898755 chr10:133777122 G/A cg17892150 chr10:133769511 PPP2R2D -0.74 -10.89 -0.51 8.4e-24 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; CRC cis rs60871478 0.588 rs6952577 chr7:872100 C/T cg13798912 chr7:905769 UNC84A 0.62 6.98 0.36 1.63e-11 Cerebrospinal P-tau181p levels; CRC cis rs798554 0.836 rs798526 chr7:2775542 G/C cg17321639 chr7:2759063 NA -0.5 -6.81 -0.35 4.69e-11 Height; CRC cis rs12048904 0.619 rs10875346 chr1:101328083 T/C cg16556008 chr1:101360663 SLC30A7;EXTL2 0.92 15.05 0.64 2.59e-39 Multiple sclerosis; CRC cis rs9527 0.571 rs3740400 chr10:104629465 T/G cg15744005 chr10:104629667 AS3MT -0.38 -7.7 -0.39 1.5700000000000001e-13 Arsenic metabolism; CRC trans rs2727020 0.595 rs10466496 chr11:49501514 C/T cg03929089 chr4:120376271 NA -0.91 -17.22 -0.69 8.15e-48 Coronary artery disease; CRC cis rs6693567 0.507 rs828784 chr1:150335240 T/A cg15654264 chr1:150340011 RPRD2 0.42 6.28 0.33 1.1e-9 Migraine; CRC cis rs826838 0.967 rs12823908 chr12:38845686 T/C cg26384229 chr12:38710491 ALG10B 0.76 10.66 0.51 5.33e-23 Heart rate; CRC trans rs12797204 0.793 rs12792825 chr11:83454878 G/A cg07421806 chr5:128301136 SLC27A6 -0.6 -5.98 -0.31 5.66e-9 Cerebrospinal fluid t-tau:AB1-42 ratio; CRC cis rs10197940 0.578 rs2444264 chr2:152310928 G/T cg19508488 chr2:152266495 RIF1 -0.44 -6.39 -0.33 5.71e-10 Lung cancer; CRC cis rs6912958 1.000 rs6937823 chr6:88160386 G/C cg08069147 chr6:88032118 GJB7;C6orf162 -0.64 -9.79 -0.47 5.17e-20 Monocyte percentage of white cells; CRC trans rs12599106 0.624 rs2173885 chr16:34992749 G/A cg01516881 chr6:292596 DUSP22 -0.66 -9.67 -0.47 1.29e-19 Menopause (age at onset); CRC cis rs6500602 0.673 rs4786513 chr16:4576423 T/C cg06139259 chr16:4526053 HMOX2;NMRAL1 0.49 6.69 0.35 9.67e-11 Schizophrenia; CRC cis rs9303401 0.659 rs7210700 chr17:56668186 G/A cg10487724 chr17:56770010 TEX14;RAD51C 0.79 9.55 0.47 3.04e-19 Cognitive test performance; CRC trans rs8002861 0.875 rs12867890 chr13:44423088 A/G cg17145862 chr1:211918768 LPGAT1 -0.72 -13.16 -0.59 4.56e-32 Leprosy; CRC cis rs25422 0.938 rs7356858 chr6:118765814 G/C cg24463073 chr6:118973353 C6orf204 0.52 6.83 0.35 4.24e-11 Renal cell carcinoma; CRC cis rs763121 0.853 rs4821810 chr22:39072098 C/G cg06022373 chr22:39101656 GTPBP1 0.82 13.73 0.6 3.15e-34 Menopause (age at onset); CRC cis rs853679 0.517 rs56364346 chr6:28050762 T/G cg15845792 chr6:28175446 NA 0.97 13.08 0.58 8.89e-32 Depression; CRC trans rs10983614 1.000 rs7867776 chr9:120072627 A/G cg11061033 chr14:23375497 RBM23 0.44 6.3 0.33 9.57e-10 Survival in pancreatic cancer; CRC cis rs7737355 0.947 rs2108869 chr5:131086880 A/G cg06307176 chr5:131281290 NA 0.41 6.15 0.32 2.22e-9 Life satisfaction; CRC cis rs3749237 1.000 rs4768 chr3:49758764 A/G cg05072774 chr3:49840536 C3orf54 -0.43 -5.65 -0.3 3.4e-8 Resting heart rate; CRC trans rs1814175 0.669 rs12416837 chr11:49669761 G/T cg21153622 chr11:89784906 NA -0.43 -7.07 -0.36 9.14e-12 Height; CRC cis rs7917772 0.503 rs56219824 chr10:104302337 C/T cg11453585 chr10:104263688 ACTR1A;SUFU 0.9 16.75 0.68 5.87e-46 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC cis rs7615952 0.599 rs2270986 chr3:125701099 T/C cg18479299 chr3:125709523 NA -0.52 -6.17 -0.32 2.03e-9 Blood pressure (smoking interaction); CRC cis rs6964587 1.000 rs7784248 chr7:91758111 A/G cg17063962 chr7:91808500 NA 0.82 14.45 0.62 5.4e-37 Breast cancer; CRC cis rs7493 0.950 rs7785846 chr7:95033841 C/T cg21856205 chr7:94953877 PON1 -0.49 -6.43 -0.33 4.48e-10 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs28386778 1.000 rs2955241 chr17:61968113 G/C cg00280220 chr17:61926910 NA 0.35 5.77 0.3 1.86e-8 Prudent dietary pattern; CRC cis rs9649213 0.614 rs12539761 chr7:98013839 C/T cg09267113 chr7:98030324 BAIAP2L1 -0.91 -11.96 -0.55 1.24e-27 Prostate cancer (SNP x SNP interaction); CRC cis rs1499614 1.000 rs2707830 chr7:66167645 T/C cg18252515 chr7:66147081 NA -1.24 -14.6 -0.63 1.48e-37 Gout; CRC cis rs9787249 0.957 rs41267029 chr1:40214367 A/G cg19912559 chr1:40204330 PPIE 0.52 7.65 0.39 2.24e-13 Blood protein levels; CRC cis rs79057730 0.599 rs6944167 chr7:826274 G/C cg11064039 chr7:766100 PRKAR1B;HEATR2 0.58 6.25 0.33 1.29e-9 Initial pursuit acceleration; CRC cis rs6961069 0.777 rs4545029 chr7:80252518 T/G cg04458919 chr7:80252533 CD36 0.35 6.27 0.33 1.11e-9 Platelet count; CRC cis rs727505 1.000 rs34986416 chr7:124441017 A/G cg23710748 chr7:124431027 NA -0.85 -14.94 -0.64 6.89e-39 Lewy body disease; CRC cis rs9420 0.807 rs12807357 chr11:57656902 C/T cg23127183 chr11:57508653 C11orf31 -0.5 -6.48 -0.34 3.33e-10 Schizophrenia; CRC cis rs12889267 0.770 rs66995536 chr14:21564859 G/A cg02988727 chr14:21567520 ZNF219;C14orf176 0.46 6.93 0.36 2.24e-11 Hematocrit;Resting heart rate; CRC cis rs17666538 0.585 rs4735812 chr8:607766 C/G cg07234876 chr8:600039 NA 0.86 7.76 0.39 1.08e-13 IgG glycosylation; CRC cis rs2404602 1.000 rs2056544 chr15:76826003 G/A cg23625390 chr15:77176239 SCAPER 0.58 8.97 0.44 2.28e-17 Blood metabolite levels; CRC cis rs7959452 0.868 rs10784774 chr12:69737879 C/T cg20891283 chr12:69753455 YEATS4 -0.73 -11.86 -0.55 3.06e-27 Blood protein levels; CRC cis rs9322193 0.884 rs9688794 chr6:149953257 C/T cg13206674 chr6:150067644 NUP43 0.62 9.29 0.46 2.24e-18 Lung cancer; CRC cis rs875971 0.545 rs75840613 chr7:65841386 G/A cg18876405 chr7:65276391 NA 0.47 6.47 0.34 3.55e-10 Aortic root size; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg20798677 chr17:39968547 FKBP10;SC65 0.39 6.5 0.34 2.94e-10 Liver disease severity in Alagille syndrome; CRC cis rs2000999 0.514 rs12928056 chr16:72225574 C/A cg04254540 chr16:71951199 KIAA0174 -0.74 -6.16 -0.32 2.15e-9 Total cholesterol levels;Cholesterol, total;Blood protein levels;LDL cholesterol levels;Haptoglobin levels;LDL cholesterol; CRC cis rs2124969 0.562 rs6750639 chr2:161066862 T/C cg03641300 chr2:160917029 PLA2R1 -0.59 -9.47 -0.46 5.74e-19 Waist circumference adjusted for body mass index; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg15032444 chr6:43027766 KLC4;MRPL2 0.42 6.19 0.32 1.75e-9 Intelligence (multi-trait analysis); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg09504352 chr12:58146286 CDK4 0.52 7.37 0.38 1.38e-12 Response to antipsychotic treatment; CRC cis rs6089584 0.854 rs2380146 chr20:60632233 C/T cg23262073 chr20:60523788 NA -0.48 -7.62 -0.39 2.72e-13 Body mass index; CRC cis rs7542091 0.637 rs9429826 chr1:210052146 G/A cg22029157 chr1:209979665 IRF6 0.47 7.41 0.38 1.06e-12 Monobrow; CRC trans rs10506458 1.000 rs10506458 chr12:63445092 G/A cg03429785 chr15:59498649 MYO1E;LDHAL6B -1.33 -19.34 -0.73 3.25e-56 Hemostatic factors and hematological phenotypes; CRC cis rs11971779 0.680 rs10274480 chr7:139052428 T/C cg07862535 chr7:139043722 LUC7L2 0.59 7.58 0.39 3.58e-13 Diisocyanate-induced asthma; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg25951811 chr14:96858416 AK7 0.39 6.64 0.34 1.29e-10 Liver disease severity in Alagille syndrome; CRC cis rs2760061 0.626 rs2527615 chr1:228119283 A/G cg02753203 chr1:228287806 NA -0.64 -9.76 -0.47 6.1e-20 Diastolic blood pressure; CRC cis rs3772130 0.540 rs7627354 chr3:121562434 A/C cg20356878 chr3:121714668 ILDR1 0.37 6.08 0.32 3.24e-9 Cognitive performance; CRC cis rs9788721 0.836 rs2009746 chr15:78754102 A/G cg18825076 chr15:78729989 IREB2 -0.44 -6.59 -0.34 1.7e-10 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio;Emphysema imaging phenotypes;Emphysema distribution in smoking;Local histogram emphysema pattern;Post bronchodilator FEV1/FVC ratio in COPD; CRC cis rs1023500 0.573 rs2269524 chr22:42475703 T/G cg25452165 chr22:42524984 CYP2D6 -0.41 -6.12 -0.32 2.63e-9 Schizophrenia; CRC cis rs1005277 0.522 rs11011343 chr10:38002698 A/G cg25427524 chr10:38739819 LOC399744 -0.73 -12.66 -0.57 3.42e-30 Extrinsic epigenetic age acceleration; CRC cis rs4843747 0.636 rs11117358 chr16:88105053 T/A cg03395651 chr16:88107091 BANP 0.59 8.02 0.4 1.84e-14 Menopause (age at onset); CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg17708938 chr17:73937173 FBF1 0.45 5.99 0.31 5.59e-9 Anxiety disorder; CRC cis rs11677416 1.000 rs1800587 chr2:113542960 C/T cg06156847 chr2:113672199 IL1F7 -0.39 -5.83 -0.31 1.3e-8 Response to antipsychotic treatment in schizophrenia (working memory); CRC cis rs2842992 1.000 rs2758322 chr6:160075188 G/T cg16489826 chr6:160211363 TCP1;MRPL18 0.47 6.26 0.33 1.18e-9 Age-related macular degeneration (geographic atrophy); CRC cis rs1801251 1.000 rs10933412 chr2:233707226 G/C cg25237894 chr2:233734115 C2orf82 -0.54 -8.75 -0.43 1.15e-16 Coronary artery disease; CRC cis rs3126085 0.935 rs11588174 chr1:152175970 C/T cg09127314 chr1:152161683 NA -0.49 -6.27 -0.33 1.15e-9 Atopic dermatitis; CRC trans rs61931739 0.559 rs4385974 chr12:34313128 G/C cg26384229 chr12:38710491 ALG10B 0.46 6.39 0.33 5.55e-10 Morning vs. evening chronotype; CRC cis rs3749237 0.595 rs4855877 chr3:49448527 T/C cg02487422 chr3:49467188 NICN1 0.42 6.89 0.35 2.9100000000000002e-11 Resting heart rate; CRC cis rs929354 1.000 rs1182389 chr7:157038803 C/T cg16102536 chr7:156981717 UBE3C 0.4 6.87 0.35 3.28e-11 Body mass index; CRC trans rs11098499 0.863 rs3775841 chr4:120425777 A/C cg25214090 chr10:38739885 LOC399744 0.64 10.08 0.49 5.4e-21 Corneal astigmatism; CRC cis rs4285028 0.948 rs7640872 chr3:121697168 C/A cg20356878 chr3:121714668 ILDR1 -0.47 -6.77 -0.35 6.03e-11 Multiple sclerosis; CRC cis rs9894429 1.000 rs4074916 chr17:79579248 G/A cg13777783 chr17:79615861 NA 0.3 5.66 0.3 3.26e-8 Eye color traits; CRC cis rs3751196 0.901 rs77013044 chr12:104197143 G/A cg02344784 chr12:104178138 NT5DC3 0.69 7.0 0.36 1.45e-11 Sense of smell; CRC cis rs1448094 0.512 rs56082822 chr12:86255475 C/T cg18827107 chr12:86230957 RASSF9 -0.45 -7.38 -0.38 1.33e-12 Major depressive disorder; CRC cis rs7616330 0.887 rs2100142 chr3:71112560 A/G cg01511742 chr3:71112437 FOXP1 -0.49 -5.66 -0.3 3.27e-8 QT interval; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg24082826 chr12:26985738 ITPR2 0.47 6.86 0.35 3.36e-11 Response to antipsychotic treatment; CRC cis rs17095355 1.000 rs12246851 chr10:111726340 C/T cg00817464 chr10:111662876 XPNPEP1 -0.63 -8.57 -0.43 4.09e-16 Biliary atresia; CRC trans rs12599106 0.624 rs2173885 chr16:34992749 G/A cg21548813 chr6:291882 DUSP22 -0.67 -9.62 -0.47 1.83e-19 Menopause (age at onset); CRC cis rs72730918 0.564 rs12441057 chr15:51896769 A/G cg14296394 chr15:51910925 DMXL2 -0.44 -5.79 -0.3 1.68e-8 Intelligence (multi-trait analysis); CRC cis rs4423214 0.840 rs1792224 chr11:71176141 C/T cg05163923 chr11:71159392 DHCR7 -0.64 -7.64 -0.39 2.32e-13 Vitamin D levels; CRC cis rs12791968 0.765 rs11038250 chr11:45009114 A/G cg11846598 chr11:44996168 LOC221122 -0.61 -9.2 -0.45 4.25e-18 Inhibitory control; CRC cis rs12594515 0.967 rs11856523 chr15:45989495 C/T cg06207120 chr15:45996521 NA 0.32 7.75 0.39 1.14e-13 Waist circumference;Weight; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg09874177 chr12:77272943 CSRP2 0.43 5.98 0.31 5.92e-9 Response to antipsychotic treatment; CRC cis rs8037137 0.915 rs77554484 chr15:91509215 C/A cg23684204 chr15:91497937 RCCD1 0.54 5.69 0.3 2.75e-8 Platelet count;Serous invasive ovarian cancer;High-grade serous ovarian cancer;Invasive epithelial ovarian cancer; CRC cis rs35146811 0.586 rs12705067 chr7:99594726 T/C cg03265037 chr7:99691720 MIR25;MCM7;MIR106B;MIR93 0.43 5.85 0.31 1.19e-8 Coronary artery disease; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg02567788 chr10:71992279 PPA1 0.48 6.8 0.35 4.82e-11 Response to antipsychotic treatment; CRC cis rs2032447 0.531 rs428469 chr6:25898624 G/A cg03517284 chr6:25882590 NA -0.85 -11.78 -0.54 5.62e-27 Intelligence (multi-trait analysis); CRC cis rs2777491 1.000 rs2730057 chr15:41736275 C/A cg18705301 chr15:41695430 NDUFAF1 -0.77 -13.16 -0.59 4.62e-32 Ulcerative colitis; CRC cis rs4601821 0.858 rs2298489 chr11:113235419 C/T cg14159747 chr11:113255604 NA -0.49 -9.81 -0.48 4.42e-20 Alcoholic chronic pancreatitis; CRC cis rs10504229 0.775 rs17216236 chr8:58159352 G/A cg24829409 chr8:58192753 C8orf71 -0.6 -8.08 -0.41 1.25e-14 Developmental language disorder (linguistic errors); CRC cis rs6539288 0.677 rs7315989 chr12:107339788 A/G cg16260113 chr12:107380972 MTERFD3 -0.4 -5.67 -0.3 3.11e-8 Total body bone mineral density; CRC cis rs6973256 0.605 rs12707114 chr7:133345207 C/G cg10665199 chr7:133106180 EXOC4 0.48 7.62 0.39 2.66e-13 Intelligence (multi-trait analysis); CRC cis rs12142240 0.698 rs1057535 chr1:46815898 T/C cg00530320 chr1:46809349 NSUN4 0.57 7.75 0.39 1.19e-13 Menopause (age at onset); CRC cis rs25645 0.502 rs7207600 chr17:38091660 G/A cg17344932 chr17:38183730 MED24;SNORD124 -0.58 -9.09 -0.45 9.7e-18 Myeloid white cell count; CRC cis rs17125944 0.505 rs77433996 chr14:53212263 G/A cg00686598 chr14:53173677 PSMC6 1.04 9.66 0.47 1.39e-19 Alzheimer's disease (late onset); CRC cis rs11031096 0.516 rs7113845 chr11:3989226 C/G cg18678763 chr11:4115507 RRM1 -0.38 -6.52 -0.34 2.64e-10 Mean corpuscular volume;Mean corpuscular hemoglobin; CRC cis rs6121246 0.909 rs6088962 chr20:30268184 C/T cg13852791 chr20:30311386 BCL2L1 0.62 8.98 0.44 2.2e-17 Mean corpuscular hemoglobin; CRC cis rs9733 0.596 rs2065900 chr1:150652202 A/G cg17724175 chr1:150552817 MCL1 0.58 9.4 0.46 9.25e-19 Tonsillectomy; CRC trans rs10982213 0.830 rs2274163 chr9:117188714 C/T cg25621096 chr1:151032116 CDC42SE1;MLLT11 0.36 6.24 0.33 1.37e-9 Interleukin-6 levels; CRC cis rs2836974 0.932 rs2836955 chr21:40619887 G/A cg07074390 chr21:40555500 PSMG1 -0.46 -6.2 -0.32 1.7e-9 Cognitive function; CRC cis rs854555 0.581 rs854537 chr7:94910248 C/T cg04155289 chr7:94953770 PON1 -0.47 -6.21 -0.32 1.61e-9 Response to TNF antagonist treatment; CRC cis rs6088580 0.634 rs1890002 chr20:32919219 A/G cg08999081 chr20:33150536 PIGU -0.62 -11.47 -0.53 7.84e-26 Glomerular filtration rate (creatinine); CRC cis rs1005277 0.540 rs1987431 chr10:37988887 T/C cg00409905 chr10:38381863 ZNF37A -0.65 -10.73 -0.51 3.22e-23 Extrinsic epigenetic age acceleration; CRC cis rs10193935 0.901 rs62142561 chr2:42477808 G/C cg27598129 chr2:42591480 NA -0.67 -7.56 -0.38 4.06e-13 Colonoscopy-negative controls vs population controls; CRC cis rs919433 0.662 rs2043018 chr2:198236958 G/A cg10820045 chr2:198174542 NA 0.45 7.89 0.4 4.58e-14 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC cis rs11864453 0.647 rs10492813 chr16:72122463 A/G cg23815491 chr16:72088622 HP -0.51 -7.67 -0.39 1.93e-13 Fibrinogen levels; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg24520871 chr10:73074265 NA 0.5 6.71 0.35 8.7e-11 Thyroid stimulating hormone; CRC cis rs10504229 0.683 rs16921807 chr8:58105967 C/T cg02290350 chr8:58132656 NA -0.59 -8.02 -0.4 1.88e-14 Developmental language disorder (linguistic errors); CRC cis rs1670533 1.000 rs6599279 chr4:1058833 G/A cg27284194 chr4:1044797 NA 0.51 6.44 0.33 4.17e-10 Recombination rate (females); CRC cis rs1801251 0.963 rs7591176 chr2:233581803 C/A cg25237894 chr2:233734115 C2orf82 0.54 8.64 0.43 2.4e-16 Coronary artery disease; CRC cis rs910316 0.967 rs175505 chr14:75529619 C/T cg11812906 chr14:75593930 NEK9 -0.64 -10.12 -0.49 4.02e-21 Height; CRC cis rs28374715 0.662 rs111522288 chr15:41480169 C/T cg18705301 chr15:41695430 NDUFAF1 -0.91 -13.84 -0.61 1.22e-34 Ulcerative colitis; CRC cis rs2011503 0.943 rs79370636 chr19:19614289 G/A cg11584989 chr19:19387371 SF4 0.57 6.39 0.33 5.7e-10 Bipolar disorder; CRC cis rs3785574 0.924 rs2727292 chr17:61893747 A/G cg22520471 chr17:61851767 DDX42;CCDC47 0.47 6.37 0.33 6.35e-10 Height; CRC cis rs4853012 0.539 rs9789534 chr2:74362990 A/T cg19729930 chr2:74357872 NA 0.55 8.67 0.43 2e-16 Gestational age at birth (maternal effect); CRC cis rs7843479 0.509 rs899428 chr8:21770763 T/C cg16476235 chr8:21771668 DOK2 0.41 6.88 0.35 3.06e-11 Mean corpuscular volume; CRC cis rs12024301 0.557 rs12023865 chr1:183634210 T/C cg11505048 chr1:183622726 RGL1;APOBEC4 0.81 7.0 0.36 1.42e-11 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs4604732 0.603 rs10925051 chr1:247641834 C/T cg02104434 chr1:247694406 LOC148824;OR2C3 0.39 6.45 0.33 4.06e-10 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CRC cis rs9916302 0.861 rs11658219 chr17:37709782 G/A cg07936489 chr17:37558343 FBXL20 -0.81 -12.26 -0.56 1.01e-28 Glomerular filtration rate (creatinine); CRC cis rs2084637 0.965 rs34614177 chr11:122411191 G/A cg21585512 chr11:122030076 LOC399959 -0.38 -6.73 -0.35 7.6e-11 Stroke; CRC cis rs9486715 0.867 rs9486181 chr6:96868132 G/A cg18709589 chr6:96969512 KIAA0776 0.47 7.01 0.36 1.34e-11 Headache; CRC cis rs3008870 1.000 rs1925408 chr1:67365034 C/T cg08660285 chr1:67390436 MIER1;WDR78 1.04 16.99 0.68 6.49e-47 Lymphocyte percentage of white cells; CRC trans rs7618501 0.572 rs4688756 chr3:50040194 T/A cg21659725 chr3:3221576 CRBN 0.52 8.08 0.41 1.28e-14 Intelligence (multi-trait analysis); CRC cis rs8062405 0.824 rs28772958 chr16:28535305 A/G cg16576597 chr16:28551801 NUPR1 0.44 6.75 0.35 6.53e-11 Cognitive ability (multi-trait analysis);Cognitive ability; CRC cis rs589448 0.872 rs315111 chr12:69784695 G/A cg22834771 chr12:69754056 YEATS4 -0.55 -8.65 -0.43 2.35e-16 Cerebrospinal fluid biomarker levels; CRC cis rs4664293 0.625 rs2114625 chr2:160543808 C/T cg08347373 chr2:160653686 CD302 -0.39 -6.48 -0.34 3.29e-10 Monocyte percentage of white cells; CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg18185028 chr3:154042079 DHX36 0.34 5.99 0.31 5.49e-9 Obesity-related traits; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg04116858 chr1:159895664 TAGLN2 0.42 6.02 0.31 4.57e-9 Intelligence (multi-trait analysis); CRC cis rs11148252 0.538 rs9535887 chr13:52730761 G/A cg00495681 chr13:53174319 NA 0.63 9.45 0.46 6.4e-19 Lewy body disease; CRC cis rs10504229 0.639 rs35527749 chr8:58128077 G/T cg24829409 chr8:58192753 C8orf71 -0.68 -8.5 -0.42 6.62e-16 Developmental language disorder (linguistic errors); CRC trans rs8073060 1.000 rs8073060 chr17:33875262 T/A cg19694781 chr19:47549865 TMEM160 0.43 6.49 0.34 3.22e-10 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; CRC cis rs7178572 1.000 rs12904938 chr15:77721225 A/G cg22256960 chr15:77711686 NA -0.7 -10.69 -0.51 4.41e-23 Type 2 diabetes; CRC cis rs16973500 0.808 rs57807129 chr16:71948043 T/C cg00732059 chr16:71740210 PHLPP2 -0.67 -6.89 -0.36 2.77e-11 Response to anti-TNF therapy in rheumatoid arthritis;Attention deficit hyperactivity disorder and conduct disorder; CRC cis rs9287719 0.967 rs759403 chr2:10729897 C/T cg00105475 chr2:10696890 NA 0.45 7.26 0.37 2.75e-12 Prostate cancer; CRC cis rs801193 0.569 rs2659907 chr7:66164032 G/A cg12463550 chr7:65579703 CRCP 0.46 6.19 0.32 1.81e-9 Aortic root size; CRC cis rs300703 0.816 rs434818 chr2:200477 G/A cg21211680 chr2:198530 NA 0.95 9.0 0.44 1.83e-17 Blood protein levels; CRC cis rs826838 0.967 rs11168299 chr12:38902028 G/T cg13010199 chr12:38710504 ALG10B 0.46 6.01 0.31 4.96e-9 Heart rate; CRC cis rs10479542 0.896 rs4701130 chr5:178982416 C/T cg19626725 chr5:178986131 RUFY1 -0.36 -7.19 -0.37 4.32e-12 Lung cancer; CRC cis rs12980942 0.591 rs3760660 chr19:41769025 A/T cg25627403 chr19:41769009 HNRNPUL1 0.56 6.45 0.34 3.93e-10 Coronary artery disease; CRC cis rs9916302 0.904 rs11078915 chr17:37715426 T/C cg00129232 chr17:37814104 STARD3 -0.56 -8.36 -0.42 1.83e-15 Glomerular filtration rate (creatinine); CRC cis rs7635838 0.686 rs347588 chr3:11287504 C/T cg00170343 chr3:11313890 ATG7 0.55 8.37 0.42 1.68e-15 HDL cholesterol; CRC cis rs7918232 0.941 rs1085782 chr10:27440517 G/A cg14240646 chr10:27532245 ACBD5 0.82 9.2 0.45 4.12e-18 Breast cancer; CRC cis rs3812111 0.524 rs12193094 chr6:116540395 C/T cg26893134 chr6:116381904 FRK 0.24 5.82 0.31 1.39e-8 Age-related macular degeneration; CRC cis rs501120 0.584 rs11238906 chr10:44685925 T/C cg09554077 chr10:44749378 NA 0.55 7.67 0.39 1.95e-13 Coronary artery disease;Coronary heart disease; CRC cis rs9486715 0.867 rs4839687 chr6:96951732 C/A cg06623918 chr6:96969491 KIAA0776 1.02 20.45 0.75 1.42e-60 Headache; CRC cis rs2456568 0.802 rs8181567 chr11:93637209 C/T cg26875233 chr11:93583750 C11orf90 -0.32 -6.27 -0.33 1.15e-9 Response to serotonin reuptake inhibitors in major depressive disorder; CRC cis rs7493 1.000 rs1034809 chr7:95051652 G/A cg01874867 chr7:94954059 PON1 -0.51 -6.39 -0.33 5.66e-10 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs7927771 0.800 rs55876153 chr11:47416636 G/A cg18512352 chr11:47633146 NA -0.41 -7.87 -0.4 5.09e-14 Subjective well-being; CRC cis rs875971 0.545 rs1267814 chr7:66044409 G/A cg11764359 chr7:65958608 NA -0.46 -5.84 -0.31 1.28e-8 Aortic root size; CRC cis rs2019137 0.936 rs731834 chr2:113957198 A/C cg21550016 chr2:113992930 PAX8;LOC440839;LOC654433 -0.51 -7.29 -0.37 2.32e-12 Lymphocyte counts; CRC cis rs1008375 0.966 rs3775924 chr4:17585984 T/C cg16339924 chr4:17578868 LAP3 0.6 7.98 0.4 2.42e-14 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs5753618 0.561 rs9609264 chr22:31746719 C/G cg07713946 chr22:31675144 LIMK2 0.41 5.93 0.31 7.84e-9 Colorectal cancer; CRC cis rs644799 1.000 rs474252 chr11:95619292 G/C cg25622487 chr11:95524042 FAM76B;CEP57 0.74 11.3 0.53 3.15e-25 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs10256972 0.591 rs6968988 chr7:1169619 A/G cg27094323 chr7:1216898 NA -0.38 -6.28 -0.33 1.04e-9 Longevity;Endometriosis; CRC cis rs4631830 0.869 rs11006207 chr10:51538176 T/C cg16070123 chr10:51489643 NA -0.34 -5.85 -0.31 1.2e-8 Prostate-specific antigen levels; CRC cis rs477692 1.000 rs485576 chr10:131425496 G/C cg05714579 chr10:131428358 MGMT 0.57 8.35 0.42 1.87e-15 Response to temozolomide; CRC cis rs950776 0.714 rs660652 chr15:78887832 A/G cg06917634 chr15:78832804 PSMA4 -0.51 -7.55 -0.38 4.4e-13 Sudden cardiac arrest; CRC cis rs2230307 0.572 rs512999 chr1:100563330 A/G cg24955406 chr1:100503596 HIAT1 0.56 6.71 0.35 8.78e-11 Carotid intima media thickness; CRC cis rs2228479 0.850 rs17227064 chr16:89816314 A/G cg06558623 chr16:89946397 TCF25 1.15 10.8 0.51 1.85e-23 Skin colour saturation; CRC cis rs2239547 0.603 rs4687698 chr3:53097108 C/T cg18404041 chr3:52824283 ITIH1 -0.34 -6.06 -0.32 3.77e-9 Schizophrenia; CRC cis rs3771570 1.000 rs73002147 chr2:242302934 T/C cg21155796 chr2:242212141 HDLBP 0.65 7.02 0.36 1.29e-11 Prostate cancer; CRC cis rs9903692 0.954 rs7209730 chr17:46207499 C/T cg21215337 chr17:46176117 CBX1 -0.42 -7.7 -0.39 1.6e-13 Pulse pressure; CRC trans rs11343 0.675 rs7359333 chr16:19262344 A/T cg06210969 chr3:120067732 LRRC58 -0.52 -6.62 -0.34 1.44e-10 Parkinson's disease; CRC cis rs908922 0.676 rs568661 chr1:152519787 C/A cg23254163 chr1:152506842 NA 0.45 8.87 0.44 4.86e-17 Hair morphology; CRC cis rs28386778 0.591 rs2584619 chr17:61913215 T/A cg06873352 chr17:61820015 STRADA 0.76 14.25 0.62 3.18e-36 Prudent dietary pattern; CRC cis rs4713118 0.786 rs200503 chr6:27785882 A/G cg06470822 chr6:28175283 NA 0.79 10.17 0.49 2.72e-21 Parkinson's disease; CRC cis rs17270561 0.609 rs4711098 chr6:25734339 C/T cg16482183 chr6:26056742 HIST1H1C 0.83 10.58 0.5 1.07e-22 Iron status biomarkers; CRC cis rs736801 0.780 rs12521868 chr5:131784393 A/C cg02033258 chr5:131593261 PDLIM4 -0.33 -6.01 -0.31 4.96e-9 Breast cancer;Mosquito bite size; CRC cis rs9487051 0.738 rs171272 chr6:109530094 T/C cg21918786 chr6:109611834 NA -0.35 -5.94 -0.31 7.17e-9 Reticulocyte fraction of red cells; CRC cis rs2760061 0.626 rs2527614 chr1:228126470 A/G cg18477163 chr1:228402036 OBSCN -0.37 -6.13 -0.32 2.46e-9 Diastolic blood pressure; CRC cis rs57590327 0.555 rs3821551 chr3:81710179 A/T cg07356753 chr3:81810745 GBE1 -0.64 -8.37 -0.42 1.7e-15 Extraversion; CRC cis rs7223966 1.000 rs11870797 chr17:61804622 C/T cg23090583 chr17:61904693 PSMC5;FTSJ3 0.5 6.18 0.32 1.89e-9 Hip circumference adjusted for BMI;Body mass index; CRC cis rs780096 0.526 rs3845687 chr2:27689899 T/C cg12000995 chr2:27665139 KRTCAP3 -0.3 -6.19 -0.32 1.76e-9 Total body bone mineral density; CRC cis rs25645 0.830 rs3935281 chr17:38188419 C/T cg17467752 chr17:38218738 THRA -0.54 -7.97 -0.4 2.6e-14 Myeloid white cell count; CRC cis rs896854 0.653 rs13266313 chr8:95975302 C/T cg16049864 chr8:95962084 TP53INP1 -0.65 -11.81 -0.55 4.64e-27 Type 2 diabetes; CRC cis rs10504229 1.000 rs72650887 chr8:58177343 G/A cg02725872 chr8:58115012 NA -0.38 -6.43 -0.33 4.61e-10 Developmental language disorder (linguistic errors); CRC cis rs10504229 0.683 rs7463453 chr8:58112053 A/G cg02290350 chr8:58132656 NA -0.6 -8.3 -0.42 2.8e-15 Developmental language disorder (linguistic errors); CRC cis rs1448094 0.549 rs10863085 chr12:86236328 G/A cg19622623 chr12:86230825 RASSF9 -0.41 -6.57 -0.34 1.94e-10 Major depressive disorder; CRC cis rs4665809 1.000 rs11126375 chr2:26344787 G/A cg25036284 chr2:26402008 FAM59B -0.46 -5.97 -0.31 6e-9 Gut microbiome composition (summer); CRC cis rs2243480 1.000 rs383402 chr7:65586653 A/C cg12463550 chr7:65579703 CRCP -0.63 -5.81 -0.3 1.51e-8 Diabetic kidney disease; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg03760316 chr18:3594197 DLGAP1;FLJ35776 0.45 6.54 0.34 2.34e-10 Response to antipsychotic treatment; CRC cis rs3731896 0.653 rs1567931 chr2:220199067 A/G cg00436969 chr2:220197716 RESP18 -0.46 -5.82 -0.31 1.37e-8 Educational attainment; CRC cis rs4908768 0.501 rs6702060 chr1:8607024 G/A cg20416874 chr1:8611966 RERE -0.46 -6.66 -0.34 1.12e-10 Neuroticism (multi-trait analysis);Subjective well-being (multi-trait analysis); CRC cis rs2859741 0.546 rs3934329 chr1:37504523 C/T cg09363841 chr1:37513479 NA -0.45 -6.98 -0.36 1.68e-11 Forced expiratory volume in 1 second (environmental tobacco smoke interaction); CRC cis rs853679 0.517 rs1947862 chr6:28105196 C/T cg18032046 chr6:28092343 ZSCAN16 -0.52 -6.03 -0.32 4.51e-9 Depression; CRC cis rs875971 0.862 rs11763189 chr7:65983529 G/A cg00343986 chr7:65444356 GUSB 0.42 5.98 0.31 5.95e-9 Aortic root size; CRC trans rs4263408 0.934 rs9683743 chr4:39703194 A/C cg07148139 chr13:52585813 ALG11;ATP7B -0.45 -6.46 -0.34 3.75e-10 Plasma amyloid beta peptide concentrations (ABx-40); CRC cis rs9811920 0.809 rs793437 chr3:99559854 C/A cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G -0.41 -5.69 -0.3 2.77e-8 Axial length; CRC cis rs7589728 0.563 rs2292868 chr2:88475047 A/G cg14558114 chr2:88469736 THNSL2 -0.58 -5.71 -0.3 2.55e-8 Plasma clusterin levels; CRC trans rs875971 0.660 rs2191268 chr7:66110224 C/T cg24497877 chr1:1244060 PUSL1;ACAP3 -0.4 -6.16 -0.32 2.08e-9 Aortic root size; CRC cis rs13256369 1.000 rs13266699 chr8:8570313 A/T cg06636001 chr8:8085503 FLJ10661 -0.48 -6.12 -0.32 2.64e-9 Obesity-related traits; CRC cis rs2742417 0.565 rs2673031 chr3:45756986 A/G cg04837898 chr3:45731254 SACM1L -0.49 -7.9 -0.4 4.31e-14 Response to anti-depressant treatment in major depressive disorder; CRC cis rs17767392 0.813 rs7152842 chr14:71849740 A/G cg13720639 chr14:72061746 SIPA1L1 -0.44 -5.79 -0.3 1.67e-8 Mitral valve prolapse; CRC cis rs4689388 0.926 rs10937720 chr4:6295451 A/G cg25554036 chr4:6271136 WFS1 0.53 8.7 0.43 1.59e-16 Type 2 diabetes and other traits;Type 2 diabetes; CRC cis rs7945718 0.621 rs4514397 chr11:12689768 G/T cg25843174 chr11:12811716 TEAD1 0.39 7.17 0.37 5.06e-12 Educational attainment (years of education); CRC cis rs1511802 0.666 rs4862663 chr4:187119228 T/A cg24794857 chr4:187113578 CYP4V2 0.42 6.03 0.32 4.51e-9 Blood protein levels; CRC cis rs10504229 0.683 rs903702 chr8:58128557 T/C cg02725872 chr8:58115012 NA -0.64 -11.55 -0.54 3.85e-26 Developmental language disorder (linguistic errors); CRC cis rs3892630 0.588 rs2287881 chr19:33333155 A/G cg22980127 chr19:33182716 NUDT19 -0.79 -10.83 -0.51 1.4e-23 Red blood cell traits; CRC trans rs2727020 0.521 rs7114564 chr11:49571231 C/T cg03929089 chr4:120376271 NA 0.74 10.19 0.49 2.22e-21 Coronary artery disease; CRC cis rs6570726 0.846 rs4896824 chr6:145927048 C/T cg13319975 chr6:146136371 FBXO30 -0.41 -5.97 -0.31 6.28e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs9457247 0.534 rs4710154 chr6:167394634 A/T cg23791538 chr6:167370224 RNASET2 0.5 7.98 0.4 2.54e-14 Crohn's disease; CRC cis rs11098499 1.000 rs1011054 chr4:120202387 A/G cg24375607 chr4:120327624 NA -0.51 -7.78 -0.39 9.38e-14 Corneal astigmatism; CRC cis rs4665809 0.877 rs34536218 chr2:26287376 T/A cg04944784 chr2:26401820 FAM59B 0.65 7.41 0.38 1.09e-12 Gut microbiome composition (summer); CRC cis rs12545109 0.800 rs1913278 chr8:57403725 T/C cg09654669 chr8:57350985 NA -0.38 -5.63 -0.3 3.97e-8 Obesity-related traits; CRC cis rs12681288 0.676 rs2701910 chr8:1001246 G/T cg04851639 chr8:1020857 NA -0.4 -7.93 -0.4 3.39e-14 Schizophrenia; CRC cis rs9787249 0.957 rs10888958 chr1:40211737 T/C cg01941586 chr1:40203715 PPIE -0.44 -6.08 -0.32 3.28e-9 Blood protein levels; CRC cis rs6582630 0.532 rs1589394 chr12:38419700 A/C cg26384229 chr12:38710491 ALG10B 0.51 7.3 0.37 2.19e-12 Drug-induced liver injury (flucloxacillin); CRC cis rs6906287 0.573 rs11153732 chr6:118704967 C/T cg07617317 chr6:118971624 C6orf204 -0.35 -5.72 -0.3 2.44e-8 Electrocardiographic conduction measures; CRC cis rs6534441 0.727 rs77517452 chr4:125457244 G/A cg21609808 chr4:125404261 NA 0.41 5.8 0.3 1.59e-8 Major depressive disorder; CRC cis rs2115630 0.875 rs8039472 chr15:85361644 A/G cg09876464 chr15:85330779 ZNF592 0.43 7.14 0.37 5.89e-12 P wave terminal force; CRC cis rs4332037 0.851 rs73050128 chr7:1961882 C/A cg23378565 chr7:2036160 MAD1L1 -0.44 -6.28 -0.33 1.06e-9 Bipolar disorder; CRC cis rs35000415 0.873 rs12539741 chr7:128596805 C/T cg19972273 chr7:128594194 NA 0.66 5.99 0.31 5.62e-9 Systemic lupus erythematosus; CRC cis rs561341 0.882 rs16967101 chr17:30377162 A/G cg00745463 chr17:30367425 LRRC37B -0.69 -8.45 -0.42 9.72e-16 Hip circumference adjusted for BMI; CRC cis rs2836974 0.590 rs11911822 chr21:40607843 C/T cg22974920 chr21:40686053 BRWD1 -0.44 -6.09 -0.32 3.16e-9 Cognitive function; CRC cis rs9837602 1.000 rs9841186 chr3:99795651 C/G cg07805332 chr3:99536008 MIR548G;C3orf26 0.47 6.17 0.32 2.04e-9 Breast cancer; CRC cis rs12188164 0.686 rs72711369 chr5:420517 C/T cg21972741 chr5:435613 AHRR 0.5 6.66 0.34 1.15e-10 Cystic fibrosis severity; CRC cis rs10504229 0.593 rs79615400 chr8:57988740 C/T cg11062466 chr8:58055876 NA 0.49 5.88 0.31 1e-8 Developmental language disorder (linguistic errors); CRC cis rs10883723 0.810 rs61873733 chr10:104251458 G/A cg22532475 chr10:104410764 TRIM8 -0.37 -6.85 -0.35 3.61e-11 Allergic disease (asthma, hay fever or eczema); CRC cis rs35306767 0.903 rs11812523 chr10:915638 C/T cg20503657 chr10:835505 NA 0.98 12.38 0.56 3.74e-29 Eosinophil percentage of granulocytes; CRC cis rs10791323 0.601 rs7946883 chr11:133733864 T/C cg06766960 chr11:133703094 NA -0.39 -6.81 -0.35 4.62e-11 Childhood ear infection; CRC cis rs9359856 0.600 rs1179899 chr6:90320258 C/T cg13799429 chr6:90582589 CASP8AP2 -0.61 -8.29 -0.42 2.88e-15 Bipolar disorder; CRC cis rs769267 0.896 rs7250893 chr19:19625547 A/G cg01262667 chr19:19385393 TM6SF2 0.36 5.96 0.31 6.35e-9 Tonsillectomy; CRC cis rs9323205 0.953 rs7141012 chr14:51600948 C/G cg23942311 chr14:51606299 NA -0.57 -6.64 -0.34 1.28e-10 Cancer; CRC cis rs7131987 0.903 rs10843371 chr12:29414232 G/A cg09582351 chr12:29534625 ERGIC2 -0.33 -6.92 -0.36 2.35e-11 QT interval; CRC cis rs1799949 1.000 rs33994002 chr17:41328818 T/A cg19454999 chr17:41278357 BRCA1;NBR2 0.55 8.62 0.43 2.95e-16 Menopause (age at onset); CRC cis rs67478160 0.619 rs12885018 chr14:104273812 A/G cg01849466 chr14:104193079 ZFYVE21 -0.46 -8.11 -0.41 1.01e-14 Schizophrenia; CRC cis rs6662572 0.686 rs72690855 chr1:46266210 G/C cg08644498 chr1:46502608 NA 0.44 6.64 0.34 1.28e-10 Blood protein levels; CRC cis rs2735413 0.875 rs8055298 chr16:78084868 C/G cg04733911 chr16:78082701 NA 0.45 7.42 0.38 1.02e-12 Systolic blood pressure (alcohol consumption interaction); CRC cis rs7914558 1.000 rs7899084 chr10:104872547 A/T cg04362960 chr10:104952993 NT5C2 0.59 8.9 0.44 3.71e-17 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs853679 0.517 rs11552219 chr6:28126834 C/T cg18032046 chr6:28092343 ZSCAN16 -0.51 -5.93 -0.31 7.47e-9 Depression; CRC trans rs1572438 0.662 rs11753072 chr6:866963 G/A cg01563465 chr5:72512441 NA 0.31 6.07 0.32 3.62e-9 Aging; CRC cis rs7760949 0.889 rs9396262 chr6:13927418 C/T cg27413430 chr6:13925136 RNF182 0.34 5.88 0.31 1.01e-8 Mean corpuscular hemoglobin concentration; CRC trans rs6951245 0.554 rs11761322 chr7:1151657 A/G cg13565492 chr6:43139072 SRF -0.83 -10.54 -0.5 1.47e-22 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs6502050 0.799 rs6502089 chr17:80169523 G/A cg09264619 chr17:80180166 NA -0.36 -6.02 -0.32 4.61e-9 Life satisfaction; CRC cis rs7811142 1.000 rs11771241 chr7:99994785 G/A cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.19 16.95 0.68 9.34e-47 Platelet count; CRC cis rs6963495 0.818 rs73192149 chr7:105210910 A/G cg13798780 chr7:105162888 PUS7 0.64 7.31 0.37 2.09e-12 Bipolar disorder (body mass index interaction); CRC cis rs9649213 0.593 rs6970801 chr7:97925240 T/C cg24562669 chr7:97807699 LMTK2 0.42 7.01 0.36 1.39e-11 Prostate cancer (SNP x SNP interaction); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg21892522 chr3:10052995 LOC401052 0.34 6.27 0.33 1.14e-9 Liver disease severity in Alagille syndrome; CRC cis rs2303759 0.551 rs7249040 chr19:49790602 C/T cg24324837 chr19:49891574 CCDC155 0.54 7.1 0.36 7.82e-12 Multiple sclerosis; CRC cis rs6748734 0.625 rs10172404 chr2:241820906 T/C cg16358738 chr2:241808595 AGXT -0.41 -7.26 -0.37 2.76e-12 Urinary metabolites; CRC cis rs10880689 1 rs10880689 chr12:37930102 A/G cg26384229 chr12:38710491 ALG10B 0.65 9.04 0.45 1.42e-17 Resting heart rate; CRC cis rs7647973 1.000 rs13088309 chr3:49368317 A/G cg20833759 chr3:49053208 WDR6;DALRD3 0.54 8.17 0.41 6.83e-15 Menarche (age at onset); CRC cis rs763121 0.853 rs6519124 chr22:39045099 T/C cg06022373 chr22:39101656 GTPBP1 0.81 13.71 0.6 3.61e-34 Menopause (age at onset); CRC trans rs11098499 0.863 rs6858592 chr4:120458692 G/A cg25214090 chr10:38739885 LOC399744 0.64 10.08 0.49 5.22e-21 Corneal astigmatism; CRC cis rs9399135 0.933 rs4559100 chr6:135324085 T/C cg24558204 chr6:135376177 HBS1L 0.51 8.13 0.41 9e-15 Red blood cell count; CRC cis rs597539 0.518 rs35093305 chr11:68730729 A/G cg06112835 chr11:68658793 MRPL21 0.39 6.12 0.32 2.7e-9 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs2204008 0.623 rs1607878 chr12:38376000 A/G cg13010199 chr12:38710504 ALG10B 0.47 6.68 0.35 9.96e-11 Bladder cancer; CRC trans rs561341 0.660 rs7406043 chr17:30220152 C/G cg20587970 chr11:113659929 NA -0.95 -11.38 -0.53 1.64e-25 Hip circumference adjusted for BMI; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg04603834 chr13:50571387 TRIM13;DLEU2 0.47 6.04 0.32 4.15e-9 Anxiety disorder; CRC cis rs2120019 1.000 rs7173833 chr15:75369618 C/T cg09165964 chr15:75287851 SCAMP5 -0.74 -11.45 -0.53 8.62e-26 Blood trace element (Zn levels); CRC trans rs2553218 0.690 rs8032415 chr15:54851945 A/G cg26483432 chr1:149815043 HIST2H2AA3;HIST2H2AA4 0.48 6.48 0.34 3.29e-10 Immune response to smallpox vaccine (IL-6); CRC cis rs6445525 1.000 rs4417899 chr3:65996110 T/C cg06109867 chr3:66002991 MAGI1 -0.39 -6.41 -0.33 5e-10 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC trans rs2797160 0.967 rs926854 chr6:126021780 A/G cg05039488 chr6:79577232 IRAK1BP1 0.52 7.73 0.39 1.36e-13 Endometrial cancer; CRC cis rs11608355 0.545 rs11615949 chr12:109894347 G/A cg05360138 chr12:110035743 NA 0.77 8.7 0.43 1.65e-16 Neuroticism; CRC cis rs11758351 1.000 rs41266807 chr6:26199822 A/G cg22723502 chr6:26240528 HIST1H4F -0.38 -5.91 -0.31 8.33e-9 Gout;Renal underexcretion gout; CRC cis rs2019137 0.539 rs11123170 chr2:113978940 C/G cg21482265 chr2:113992762 PAX8;LOC440839;LOC654433 0.64 9.6 0.47 2.07e-19 Lymphocyte counts; CRC trans rs3733585 0.699 rs6844316 chr4:9958977 A/G cg26043149 chr18:55253948 FECH -0.5 -7.62 -0.39 2.81e-13 Cleft plate (environmental tobacco smoke interaction); CRC cis rs7224685 0.906 rs2278524 chr17:4081975 A/G cg09695851 chr17:3907499 NA -0.45 -6.57 -0.34 1.97e-10 Type 2 diabetes; CRC cis rs6752107 0.936 rs10195395 chr2:234206504 T/C cg07618928 chr2:234183455 ATG16L1;SCARNA5 0.59 9.48 0.46 5.36e-19 Crohn's disease;Inflammatory bowel disease; CRC cis rs720844 0.832 rs764386 chr2:149285506 G/A cg09247360 chr2:149335327 NA -0.5 -6.02 -0.31 4.75e-9 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs7613875 0.600 rs2856238 chr3:50158191 C/T cg05623727 chr3:50126028 RBM5 0.58 10.15 0.49 3.16e-21 Body mass index; CRC cis rs763121 0.853 rs5750622 chr22:38956464 C/G cg06022373 chr22:39101656 GTPBP1 0.71 10.54 0.5 1.38e-22 Menopause (age at onset); CRC trans rs34476593 0.943 rs7637968 chr3:23904969 C/T cg09448314 chr17:73496215 KIAA0195 -0.48 -6.08 -0.32 3.28e-9 Intelligence (multi-trait analysis); CRC cis rs25422 0.540 rs9481842 chr6:118974798 A/C cg22561889 chr6:118971681 C6orf204 0.39 5.63 0.3 3.95e-8 Renal cell carcinoma; CRC cis rs763121 0.853 rs5750621 chr22:38956166 C/T cg06544989 chr22:39130855 UNC84B 0.41 6.1 0.32 3.03e-9 Menopause (age at onset); CRC cis rs644799 0.544 rs525087 chr11:95632266 G/A cg25622487 chr11:95524042 FAM76B;CEP57 0.5 7.47 0.38 7.48e-13 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs7219014 1 rs7219014 chr17:37624790 A/G cg00129232 chr17:37814104 STARD3 -0.55 -8.05 -0.41 1.52e-14 Urinary metabolites; CRC cis rs9583531 0.891 rs3742182 chr13:111375132 C/T cg24331049 chr13:111365604 ING1 0.52 5.82 0.31 1.38e-8 Coronary artery disease; CRC cis rs853679 0.517 rs9368555 chr6:28108967 T/C cg23161317 chr6:28129485 ZNF389 0.53 6.43 0.33 4.52e-10 Depression; CRC cis rs6743226 0.901 rs12478458 chr2:242237856 A/G cg10021735 chr2:242295487 FARP2 0.46 6.57 0.34 1.92e-10 Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI in non-smokers; CRC cis rs73206853 0.841 rs3026486 chr12:110782532 C/T cg12870014 chr12:110450643 ANKRD13A 0.8 7.71 0.39 1.55e-13 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC cis rs9303280 0.806 rs2872507 chr17:38040763 C/T cg00129232 chr17:37814104 STARD3 -0.39 -6.14 -0.32 2.4e-9 Self-reported allergy; CRC cis rs17713451 0.593 rs76331945 chr7:151269055 C/T cg18404559 chr7:151322523 PRKAG2 -0.57 -6.41 -0.33 5.12e-10 Interleukin-4 levels; CRC trans rs11225569 0.539 rs9787739 chr11:103333744 C/T cg01615333 chr12:127765195 NA -0.64 -6.03 -0.32 4.37e-9 Diisocyanate-induced asthma; CRC cis rs2072499 0.966 rs6427304 chr1:156156789 A/G cg06970220 chr1:156163860 SLC25A44 0.47 6.62 0.34 1.47e-10 Testicular germ cell tumor; CRC trans rs2303319 0.504 rs58622044 chr2:162596287 A/G cg25193742 chr10:104614220 C10orf32 -0.76 -6.42 -0.33 4.8e-10 Cognitive function; CRC cis rs12971120 0.891 rs4891557 chr18:72170299 C/T cg26446133 chr18:72167187 CNDP2 -0.76 -11.27 -0.53 3.93e-25 Refractive error; CRC cis rs172166 0.694 rs2791332 chr6:28108788 C/T cg23161317 chr6:28129485 ZNF389 0.46 6.51 0.34 2.86e-10 Cardiac Troponin-T levels; CRC cis rs10504229 0.639 rs2291764 chr8:58142943 A/C cg24829409 chr8:58192753 C8orf71 -0.69 -8.56 -0.43 4.41e-16 Developmental language disorder (linguistic errors); CRC cis rs9916302 0.904 rs57399933 chr17:37551189 A/G cg15445000 chr17:37608096 MED1 -0.43 -9.48 -0.46 5.3e-19 Glomerular filtration rate (creatinine); CRC cis rs1707322 0.716 rs28370457 chr1:46172062 C/T cg03146154 chr1:46216737 IPP 0.67 9.73 0.47 7.77e-20 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg08412305 chr1:167904990 DCAF6;BRP44 0.43 6.25 0.33 1.28e-9 Intelligence (multi-trait analysis); CRC cis rs929354 1.000 rs1182414 chr7:157058363 G/A cg17757837 chr7:157058334 UBE3C -0.88 -17.0 -0.68 5.71e-47 Body mass index; CRC cis rs2228479 0.850 rs17226966 chr16:89825338 A/G cg19635926 chr16:89946313 TCF25 0.63 5.68 0.3 3.01e-8 Skin colour saturation; CRC cis rs67478160 0.643 rs11160762 chr14:104255083 A/G cg08213375 chr14:104286397 PPP1R13B -0.64 -13.83 -0.61 1.34e-34 Schizophrenia; CRC cis rs9341808 0.690 rs2322634 chr6:80874014 A/C cg08355045 chr6:80787529 NA 0.42 6.82 0.35 4.42e-11 Sitting height ratio; CRC trans rs79976124 0.800 rs10944857 chr6:66637078 C/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.72 9.09 0.45 9.43e-18 Type 2 diabetes; CRC cis rs6062302 0.549 rs4809586 chr20:62249402 C/T cg16989086 chr20:62203971 PRIC285 0.51 6.54 0.34 2.41e-10 Glioblastoma; CRC cis rs3749237 1.000 rs6804655 chr3:49738945 C/T cg24308560 chr3:49941425 MST1R -0.43 -6.2 -0.32 1.68e-9 Resting heart rate; CRC cis rs2013441 0.932 rs2526488 chr17:20098617 T/A cg13482628 chr17:19912719 NA -0.41 -6.24 -0.33 1.33e-9 Obesity-related traits; CRC cis rs3820068 0.705 rs72645803 chr1:15868232 G/A cg27534772 chr1:16042836 PLEKHM2 0.42 6.95 0.36 2.02e-11 Systolic blood pressure; CRC cis rs4332037 0.851 rs73050128 chr7:1961882 C/A cg24505167 chr7:1915268 MAD1L1 -0.44 -6.14 -0.32 2.4e-9 Bipolar disorder; CRC cis rs561341 0.941 rs112569713 chr17:30271738 C/T cg00745463 chr17:30367425 LRRC37B -0.75 -9.09 -0.45 9.8e-18 Hip circumference adjusted for BMI; CRC cis rs7618915 0.547 rs2289250 chr3:52682946 A/C cg10802521 chr3:52805072 NEK4 0.59 9.11 0.45 8.17e-18 Bipolar disorder; CRC cis rs3741404 0.583 rs640999 chr11:63869425 C/A cg19465662 chr11:63993652 NUDT22;TRPT1 0.6 9.33 0.46 1.59e-18 Platelet count; CRC trans rs2228479 0.850 rs3785281 chr16:89824263 G/C cg24644049 chr4:85504048 CDS1 0.86 6.93 0.36 2.29e-11 Skin colour saturation; CRC trans rs208515 0.592 rs10944862 chr6:66674215 C/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.93 11.75 0.54 7.28e-27 Exhaled nitric oxide levels; CRC cis rs11864453 0.614 rs12445586 chr16:72126276 C/T cg01557791 chr16:72042693 DHODH -0.43 -6.0 -0.31 5.07e-9 Fibrinogen levels; CRC cis rs1524976 1.000 rs11707527 chr3:65450416 G/A cg16238336 chr3:65465873 MAGI1 -0.5 -6.91 -0.36 2.54e-11 PR interval; CRC cis rs853679 0.824 rs34712084 chr6:28043828 A/G cg15786705 chr6:28176104 NA 0.7 5.88 0.31 1e-8 Depression; CRC cis rs10504229 0.610 rs6999661 chr8:58127391 C/G cg05313129 chr8:58192883 C8orf71 -0.43 -6.11 -0.32 2.74e-9 Developmental language disorder (linguistic errors); CRC cis rs853679 0.517 rs1947862 chr6:28105196 C/T cg02683197 chr6:28174875 NA 0.85 10.5 0.5 1.96e-22 Depression; CRC cis rs6665290 0.935 rs17600627 chr1:227201449 A/G cg10327440 chr1:227177885 CDC42BPA -1.02 -21.94 -0.77 2.28e-66 Myeloid white cell count; CRC cis rs6088580 0.634 rs6059887 chr20:33101102 C/G cg24642439 chr20:33292090 TP53INP2 0.39 6.59 0.34 1.73e-10 Glomerular filtration rate (creatinine); CRC cis rs939574 1.000 rs79013471 chr2:220096122 C/A cg00496455 chr2:220118770 TUBA4A;TUBA4B 0.92 9.34 0.46 1.45e-18 Platelet distribution width; CRC cis rs763014 0.966 rs12935215 chr16:670605 T/C cg04562611 chr16:615315 C16orf11 0.38 6.49 0.34 3.21e-10 Height; CRC cis rs875971 0.862 rs778684 chr7:65836403 A/T cg11764359 chr7:65958608 NA 0.6 9.25 0.45 2.86e-18 Aortic root size; CRC cis rs907683 0.584 rs2854903 chr2:220288979 C/T cg15015639 chr2:220282977 DES -0.39 -6.35 -0.33 7.21e-10 Resting heart rate; CRC cis rs1707322 0.721 rs10890343 chr1:46157922 C/T cg03146154 chr1:46216737 IPP 0.67 9.8 0.48 4.6e-20 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs10744422 1.000 rs10744422 chr12:123336789 T/C cg25930673 chr12:123319894 HIP1R -0.61 -6.32 -0.33 8.56e-10 Schizophrenia; CRC cis rs853679 0.517 rs6932109 chr6:28078303 A/G cg02683197 chr6:28174875 NA -0.84 -10.93 -0.52 6.1e-24 Depression; CRC cis rs1801251 0.778 rs809639 chr2:233731244 C/G cg25237894 chr2:233734115 C2orf82 0.61 11.09 0.52 1.69e-24 Coronary artery disease; CRC cis rs61996546 0.595 rs12901348 chr15:26869266 T/A cg15066197 chr15:26874202 GABRB3 -0.39 -6.02 -0.32 4.59e-9 Response to methotrexate in juvenile idiopathic arthritis; CRC trans rs12517041 1.000 rs10805750 chr5:23300753 C/A ch.8.1293020R chr8:59333349 UBXN2B -0.54 -5.96 -0.31 6.46e-9 Calcium levels; CRC cis rs10911363 0.615 rs9286848 chr1:183426249 C/G cg09173681 chr1:183549694 NCF2 -0.74 -10.15 -0.49 3.08e-21 Systemic lupus erythematosus; CRC cis rs12681288 0.823 rs4735974 chr8:1000218 T/G cg15309053 chr8:964076 NA 0.4 7.37 0.38 1.39e-12 Schizophrenia; CRC cis rs72615157 0.634 rs2272343 chr7:99778285 A/C cg19337854 chr7:99768885 GPC2 0.48 6.42 0.33 4.73e-10 Lung function (FEV1/FVC); CRC cis rs9527 0.590 rs7897663 chr10:104905604 T/C cg04362960 chr10:104952993 NT5C2 0.6 8.32 0.42 2.32e-15 Arsenic metabolism; CRC cis rs6723226 0.767 rs10172308 chr2:32555760 G/A cg02381751 chr2:32503542 YIPF4 -0.65 -9.45 -0.46 6.48e-19 Intelligence (multi-trait analysis); CRC cis rs2032447 0.798 rs807212 chr6:26065621 A/G cg12310025 chr6:25882481 NA -0.52 -7.11 -0.37 7.1e-12 Intelligence (multi-trait analysis); CRC cis rs10504229 1.000 rs73607875 chr8:58173522 T/C cg01721255 chr8:58191610 C8orf71 0.49 6.17 0.32 2e-9 Developmental language disorder (linguistic errors); CRC cis rs12286929 0.702 rs11215419 chr11:115081810 A/T cg04055981 chr11:115044050 NA 0.39 6.1 0.32 2.93e-9 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg22416253 chr18:21977947 OSBPL1A 0.39 6.1 0.32 2.95e-9 Liver disease severity in Alagille syndrome; CRC cis rs11676348 0.935 rs2230054 chr2:219000310 C/T cg00012203 chr2:219082015 ARPC2 -0.39 -6.03 -0.32 4.4e-9 Ulcerative colitis; CRC cis rs9517320 1.000 rs12864890 chr13:99126457 T/C cg20487152 chr13:99095054 FARP1 0.36 5.88 0.31 1e-8 Longevity; CRC cis rs9443645 0.808 rs2050661 chr6:79661125 T/C cg05283184 chr6:79620031 NA -0.58 -9.18 -0.45 5.09e-18 Intelligence (multi-trait analysis); CRC cis rs72945132 0.882 rs11235739 chr11:70132780 C/T cg00319359 chr11:70116639 PPFIA1 0.59 6.7 0.35 8.93e-11 Coronary artery disease; CRC cis rs10464366 0.519 rs6974609 chr7:39219149 C/T cg15212455 chr7:39170539 POU6F2 0.47 6.09 0.32 3.21e-9 IgG glycosylation; CRC cis rs7412746 0.634 rs4451553 chr1:150937329 C/T cg15448220 chr1:150897856 SETDB1 0.58 8.47 0.42 8.37e-16 Melanoma; CRC cis rs7811142 0.943 rs10241492 chr7:99994813 A/G cg00814883 chr7:100076585 TSC22D4 -0.74 -9.24 -0.45 3.14e-18 Platelet count; CRC cis rs1953600 0.870 rs2573370 chr10:81951366 C/T cg00277334 chr10:82204260 NA 0.37 5.91 0.31 8.4e-9 Sarcoidosis; CRC cis rs12519773 0.555 rs2009416 chr5:92415111 C/T cg18783429 chr5:92414398 NA 0.34 7.04 0.36 1.1e-11 Migraine; CRC cis rs12824058 0.844 rs7956408 chr12:130807547 A/T cg14604444 chr12:130766091 NA -0.39 -6.03 -0.32 4.44e-9 Menopause (age at onset); CRC cis rs4638749 0.677 rs9631035 chr2:108818916 C/T cg25838818 chr2:108905173 SULT1C2 -0.34 -5.71 -0.3 2.52e-8 Blood pressure; CRC cis rs600806 0.850 rs3879452 chr1:109929237 G/A cg23032129 chr1:109941072 SORT1 -0.28 -6.06 -0.32 3.68e-9 Intelligence (multi-trait analysis); CRC cis rs9487051 0.844 rs9386792 chr6:109609975 G/A cg01475377 chr6:109611718 NA -0.49 -9.28 -0.46 2.32e-18 Reticulocyte fraction of red cells; CRC cis rs796364 0.806 rs12616905 chr2:201007764 C/G cg25936922 chr2:200820526 C2orf60;C2orf47 -0.65 -6.15 -0.32 2.23e-9 Schizophrenia; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg00396991 chr1:161494029 HSPA6 0.43 6.55 0.34 2.16e-10 Liver disease severity in Alagille syndrome; CRC cis rs12824058 0.831 rs12314111 chr12:130813663 G/T cg24838063 chr12:130822603 PIWIL1 0.57 9.6 0.47 2.08e-19 Menopause (age at onset); CRC cis rs11247915 0.501 rs34209692 chr1:26608782 C/T cg04990556 chr1:26633338 UBXN11 -0.47 -5.77 -0.3 1.8e-8 Obesity-related traits; CRC trans rs11814448 1.000 rs12248406 chr10:22319508 A/G cg08492145 chr7:157648386 PTPRN2 0.64 6.31 0.33 8.85e-10 Breast cancer; CRC cis rs11155671 0.546 rs1999633 chr6:150187712 C/T cg13206674 chr6:150067644 NUP43 0.47 6.25 0.33 1.29e-9 Testicular germ cell tumor; CRC cis rs3731896 0.653 rs58269809 chr2:220196013 T/C cg00436969 chr2:220197716 RESP18 -0.45 -5.72 -0.3 2.43e-8 Educational attainment; CRC cis rs12477438 0.520 rs2632283 chr2:99776000 C/G cg26064155 chr2:99771622 LIPT1;TSGA10 0.77 13.13 0.59 5.79e-32 Chronic sinus infection; CRC cis rs6502050 0.637 rs74765203 chr17:80118223 A/G cg09264619 chr17:80180166 NA -0.34 -5.74 -0.3 2.12e-8 Life satisfaction; CRC cis rs11758351 0.660 rs11757754 chr6:26219744 A/C cg10723962 chr6:26240782 HIST1H4F -0.38 -6.09 -0.32 3.14e-9 Gout;Renal underexcretion gout; CRC trans rs9388451 0.626 rs1343115 chr6:126069817 C/G cg05039488 chr6:79577232 IRAK1BP1 -0.74 -12.93 -0.58 3.26e-31 Brugada syndrome; CRC cis rs10504229 1.000 rs67237174 chr8:58175776 T/C cg02725872 chr8:58115012 NA -0.38 -6.39 -0.33 5.58e-10 Developmental language disorder (linguistic errors); CRC cis rs875971 0.964 rs6978429 chr7:65959876 T/G cg11764359 chr7:65958608 NA 0.63 10.25 0.49 1.39e-21 Aortic root size; CRC cis rs898097 0.625 rs7406464 chr17:80891460 A/G cg19046167 chr17:80928561 B3GNTL1 -0.44 -7.51 -0.38 5.73e-13 Breast cancer; CRC cis rs1267303 0.642 rs2404611 chr1:46997127 C/G cg25110126 chr1:46999211 NA 0.54 7.6 0.39 3.11e-13 Monobrow; CRC cis rs12188164 1.000 rs34453673 chr5:434722 G/C cg21972741 chr5:435613 AHRR 0.54 7.42 0.38 1.04e-12 Cystic fibrosis severity; CRC cis rs2742417 1.000 rs2673056 chr3:45737802 C/T cg04837898 chr3:45731254 SACM1L -0.34 -5.67 -0.3 3.08e-8 Response to anti-depressant treatment in major depressive disorder; CRC cis rs1816752 0.905 rs9511264 chr13:25012217 C/T cg02811702 chr13:24901961 NA -0.46 -6.48 -0.34 3.42e-10 Obesity-related traits; CRC cis rs9467773 0.620 rs2504540 chr6:26641626 A/G cg09904177 chr6:26538194 HMGN4 0.71 11.27 0.53 4.09e-25 Intelligence (multi-trait analysis); CRC cis rs9948 0.655 rs17119562 chr2:97381844 G/C cg20312557 chr2:97357134 FER1L5 -0.61 -5.72 -0.3 2.41e-8 Erectile dysfunction and prostate cancer treatment; CRC cis rs9326248 0.817 rs1242127 chr11:117076564 A/G cg26566898 chr11:117069891 TAGLN -0.44 -9.03 -0.45 1.53e-17 Blood protein levels; CRC cis rs11630290 1.000 rs72750987 chr15:63999112 G/C cg12036633 chr15:63758958 NA -0.56 -5.81 -0.3 1.51e-8 Iris characteristics; CRC cis rs250677 0.958 rs36078 chr5:148430567 G/A cg23229984 chr5:148520753 ABLIM3 0.54 7.24 0.37 3.29e-12 Breast cancer; CRC cis rs7618915 0.547 rs62253700 chr3:52625019 T/A cg08222913 chr3:52553049 STAB1 -0.34 -6.19 -0.32 1.77e-9 Bipolar disorder; CRC cis rs12497850 0.765 rs12487580 chr3:49182932 G/A cg20833759 chr3:49053208 WDR6;DALRD3 0.45 7.23 0.37 3.48e-12 Parkinson's disease; CRC cis rs8028182 0.609 rs10220738 chr15:75666546 A/T cg20655648 chr15:75932815 IMP3 -0.42 -6.36 -0.33 6.59e-10 Sudden cardiac arrest; CRC cis rs9611565 0.765 rs202659 chr22:41811620 T/C cg06634786 chr22:41940651 POLR3H 0.6 6.97 0.36 1.7e-11 Vitiligo; CRC cis rs1997103 1.000 rs6949222 chr7:55411264 C/T cg17469321 chr7:55412551 NA 0.72 11.28 0.53 3.48e-25 QRS interval (sulfonylurea treatment interaction); CRC cis rs6940638 0.715 rs9348751 chr6:27067190 T/A cg12292205 chr6:26970375 C6orf41 -0.47 -6.57 -0.34 1.94e-10 Intelligence (multi-trait analysis); CRC cis rs780096 0.526 rs1260342 chr2:27663416 G/T cg21248554 chr2:27665150 KRTCAP3 -0.34 -7.95 -0.4 3.07e-14 Total body bone mineral density; CRC cis rs798554 0.683 rs1182155 chr7:2902890 C/G cg04166393 chr7:2884313 GNA12 0.48 6.77 0.35 5.84e-11 Height; CRC cis rs270601 0.913 rs273899 chr5:131695178 G/A cg24060327 chr5:131705240 SLC22A5 -0.53 -7.94 -0.4 3.23e-14 Acylcarnitine levels; CRC cis rs2836974 0.623 rs34240248 chr21:40685239 A/G cg22974920 chr21:40686053 BRWD1 -0.43 -5.75 -0.3 2.04e-8 Cognitive function; CRC cis rs2243480 0.901 rs13237344 chr7:66022256 T/A cg18252515 chr7:66147081 NA -1.27 -15.03 -0.64 3.14e-39 Diabetic kidney disease; CRC cis rs7072216 0.881 rs755126 chr10:100148951 G/A cg26618903 chr10:100175079 PYROXD2 -0.37 -6.2 -0.32 1.72e-9 Metabolite levels; CRC cis rs908922 0.651 rs1337341 chr1:152508259 A/C cg09873164 chr1:152488093 CRCT1 0.39 6.36 0.33 6.83e-10 Hair morphology; CRC cis rs7666738 0.830 rs1869082 chr4:98841254 T/A cg17366294 chr4:99064904 C4orf37 0.41 6.57 0.34 1.92e-10 Colonoscopy-negative controls vs population controls; CRC cis rs427941 0.694 rs2529094 chr7:101739617 C/T cg06246474 chr7:101738831 CUX1 0.46 7.23 0.37 3.35e-12 Plasma omega-3 polyunsaturated fatty acid level (eicosapentaenoic acid); CRC cis rs7264396 0.515 rs2425134 chr20:34339439 G/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.45 -6.15 -0.32 2.24e-9 Total cholesterol levels; CRC cis rs853679 1.000 rs11965538 chr6:28239915 G/A cg15786705 chr6:28176104 NA 0.59 6.05 0.32 3.84e-9 Depression; CRC cis rs7829975 0.742 rs1533059 chr8:8684953 A/G cg14979609 chr8:8086686 FLJ10661 0.37 5.86 0.31 1.13e-8 Mood instability; CRC cis rs477895 0.938 rs28395875 chr11:64024048 G/C cg18375707 chr11:64034959 PLCB3 0.48 6.0 0.31 5.28e-9 Mean platelet volume; CRC cis rs67311347 1.000 rs13095055 chr3:40505666 G/T cg09455208 chr3:40491958 NA -0.45 -8.95 -0.44 2.67e-17 Renal cell carcinoma; CRC cis rs4478858 0.775 rs6701667 chr1:31707971 A/C cg00250761 chr1:31883323 NA -0.37 -7.25 -0.37 2.96e-12 Alcohol dependence; CRC cis rs847577 0.515 rs10953238 chr7:97676259 C/T cg00277769 chr7:97922759 BAIAP2L1 -0.37 -6.2 -0.32 1.73e-9 Breast cancer; CRC cis rs11122272 0.766 rs2790871 chr1:231543555 G/C cg06096015 chr1:231504339 EGLN1 0.38 5.63 0.3 3.81e-8 Hemoglobin concentration; CRC cis rs116095464 0.558 rs10060089 chr5:205565 G/A cg22857025 chr5:266934 NA -1.14 -11.87 -0.55 2.78e-27 Breast cancer; CRC cis rs10046574 0.831 rs10251162 chr7:135190264 C/T cg27474649 chr7:135195673 CNOT4 0.69 5.7 0.3 2.61e-8 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs1506636 1.000 rs767637 chr7:123321978 C/A cg03229431 chr7:123269106 ASB15 -0.73 -11.71 -0.54 1.03e-26 Plateletcrit;Platelet count; CRC cis rs12928939 0.954 rs34998650 chr16:71829329 T/C cg08717414 chr16:71523259 ZNF19 -0.5 -6.19 -0.32 1.75e-9 Post bronchodilator FEV1; CRC trans rs61931739 0.534 rs1826144 chr12:34094272 A/G cg26384229 chr12:38710491 ALG10B 0.55 7.02 0.36 1.27e-11 Morning vs. evening chronotype; CRC cis rs11758351 0.587 rs10484436 chr6:26237155 C/T cg22723502 chr6:26240528 HIST1H4F -0.37 -5.98 -0.31 5.88e-9 Gout;Renal underexcretion gout; CRC cis rs9826463 0.702 rs73228758 chr3:142320559 A/G cg20824294 chr3:142316082 PLS1 0.42 6.84 0.35 3.86e-11 QRS duration in Tripanosoma cruzi seropositivity; CRC cis rs7208859 0.623 rs9890855 chr17:29111707 G/C cg01831904 chr17:28903510 LRRC37B2 -0.63 -6.45 -0.33 4.07e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs9322193 0.923 rs12174035 chr6:150084447 A/T cg07701084 chr6:150067640 NUP43 0.44 6.26 0.33 1.18e-9 Lung cancer; CRC cis rs2882667 0.619 rs6861556 chr5:138188040 C/T cg09476006 chr5:138032270 NA -0.55 -9.29 -0.46 2.24e-18 Age-related hearing impairment (SNP x SNP interaction); CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg05967129 chr7:127544716 SND1 -0.49 -6.01 -0.31 4.91e-9 Diisocyanate-induced asthma; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg14274609 chr10:123687846 ATE1 0.51 7.05 0.36 1.08e-11 Anxiety disorder; CRC cis rs561341 0.883 rs1034626 chr17:30219500 C/G cg19193384 chr17:30244184 NA 0.48 6.09 0.32 3.08e-9 Hip circumference adjusted for BMI; CRC cis rs2404602 0.532 rs284892 chr15:76721037 A/G cg23625390 chr15:77176239 SCAPER 0.58 8.79 0.44 8.72e-17 Blood metabolite levels; CRC cis rs916888 0.773 rs1378358 chr17:44787312 C/T cg15921436 chr17:44337874 NA 0.82 8.53 0.43 5.3e-16 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs853679 0.550 rs9295762 chr6:28155418 C/T cg15845792 chr6:28175446 NA -0.99 -14.79 -0.63 2.76e-38 Depression; CRC cis rs2011503 0.941 rs80146298 chr19:19426317 C/T cg11584989 chr19:19387371 SF4 0.55 5.82 0.31 1.36e-8 Bipolar disorder; CRC cis rs6860806 0.661 rs1588263 chr5:131577158 T/C cg12564285 chr5:131593104 PDLIM4 0.5 9.67 0.47 1.27e-19 Breast cancer; CRC cis rs4076764 0.914 rs4638099 chr1:163365521 A/G cg24596788 chr1:163392923 NA 0.66 10.72 0.51 3.48e-23 Motion sickness; CRC cis rs7615952 0.866 rs6438949 chr3:125650064 G/C cg05084668 chr3:125655381 ALG1L -0.65 -10.13 -0.49 3.52e-21 Blood pressure (smoking interaction); CRC cis rs561341 1.000 rs537166 chr17:30326827 C/T cg19193384 chr17:30244184 NA -0.54 -6.94 -0.36 2.14e-11 Hip circumference adjusted for BMI; CRC cis rs4731207 0.596 rs1994024 chr7:124660845 A/G cg23710748 chr7:124431027 NA -0.38 -5.98 -0.31 5.68e-9 Cutaneous malignant melanoma; CRC trans rs10842750 1.000 rs10842750 chr12:26690565 G/T cg03919779 chr17:16284127 UBB 0.49 5.98 0.31 5.67e-9 Kashin-Beck disease; CRC trans rs7615952 0.932 rs6438948 chr3:125650045 A/T cg02560186 chr11:3602584 NA 0.46 6.51 0.34 2.79e-10 Blood pressure (smoking interaction); CRC cis rs9649213 0.593 rs62478200 chr7:97980045 A/G cg24562669 chr7:97807699 LMTK2 0.45 7.43 0.38 9.75e-13 Prostate cancer (SNP x SNP interaction); CRC cis rs798554 0.757 rs1182179 chr7:2873648 A/G cg13628971 chr7:2884303 GNA12 0.53 7.15 0.37 5.77e-12 Height; CRC cis rs875971 0.862 rs6955837 chr7:66043142 C/T cg12463550 chr7:65579703 CRCP -0.47 -6.38 -0.33 5.88e-10 Aortic root size; CRC cis rs7605827 0.836 rs4396685 chr2:15634407 C/T cg19274914 chr2:15703543 NA 0.4 6.05 0.32 4e-9 Educational attainment (years of education); CRC cis rs2742417 1.000 rs938363 chr3:45746364 T/G cg04837898 chr3:45731254 SACM1L -0.36 -5.92 -0.31 7.98e-9 Response to anti-depressant treatment in major depressive disorder; CRC cis rs12580194 0.957 rs56380243 chr12:55690727 A/G cg19537932 chr12:55886519 OR6C68 -0.57 -7.9 -0.4 4.11e-14 Cancer; CRC cis rs10924970 0.649 rs3765795 chr1:235375819 A/G cg09010748 chr1:235293032 TOMM20 0.42 5.71 0.3 2.48e-8 Asthma; CRC cis rs72781680 0.716 rs2551343 chr2:24027002 C/G cg08917208 chr2:24149416 ATAD2B 0.53 6.36 0.33 6.58e-10 Lymphocyte counts; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg25998860 chr5:126853954 PRRC1 0.47 6.72 0.35 8.03e-11 Response to antipsychotic treatment; CRC cis rs67311347 0.955 rs1129200 chr3:40532257 T/C cg09455208 chr3:40491958 NA 0.43 8.41 0.42 1.23e-15 Renal cell carcinoma; CRC cis rs9648716 0.935 rs28605757 chr7:140631695 G/A cg10747023 chr7:140774559 NA 0.46 6.02 0.31 4.76e-9 Type 2 diabetes; CRC cis rs7584330 0.657 rs10202599 chr2:238352465 A/C cg11271282 chr2:238384023 NA 0.45 5.71 0.3 2.54e-8 Prostate cancer; CRC cis rs1801251 0.929 rs12694917 chr2:233707611 C/T cg25237894 chr2:233734115 C2orf82 -0.5 -8.19 -0.41 6e-15 Coronary artery disease; CRC cis rs11690935 0.851 rs10930502 chr2:172890588 A/G cg13550731 chr2:172543902 DYNC1I2 -0.88 -13.11 -0.59 7.17e-32 Schizophrenia; CRC cis rs370915 1.000 rs9685837 chr4:187818466 C/T cg19519643 chr4:187840862 NA -0.48 -7.33 -0.37 1.79e-12 Gout; CRC trans rs11227306 0.934 rs11227315 chr11:65590389 C/A cg17712092 chr4:129076599 LARP1B 0.52 6.85 0.35 3.62e-11 DNA methylation (variation); CRC trans rs2303319 0.504 rs62190168 chr2:162322012 A/G cg04145477 chr6:107077629 RTN4IP1;QRSL1 -0.84 -6.27 -0.33 1.13e-9 Cognitive function; CRC cis rs3812049 0.667 rs6888037 chr5:127406259 G/T cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.79 9.64 0.47 1.56e-19 Lymphocyte counts;Red cell distribution width; CRC cis rs1997103 1.000 rs10279035 chr7:55412055 C/T cg17469321 chr7:55412551 NA 0.72 11.16 0.52 9.35e-25 QRS interval (sulfonylurea treatment interaction); CRC cis rs2019137 0.539 rs4849177 chr2:113982584 T/C cg01577475 chr2:114033581 PAX8;LOC440839 -0.25 -6.27 -0.33 1.12e-9 Lymphocyte counts; CRC cis rs294883 0.739 rs13205563 chr6:159704376 A/G cg14500486 chr6:159655392 FNDC1 -0.35 -5.81 -0.3 1.5e-8 Coronary artery disease; CRC cis rs17376456 0.825 rs12153021 chr5:93073913 A/G cg21475434 chr5:93447410 FAM172A 0.71 6.79 0.35 5.34e-11 Diabetic retinopathy; CRC trans rs9858542 0.953 rs12330269 chr3:49513910 G/A cg21582582 chr3:182698605 DCUN1D1 -0.51 -6.47 -0.34 3.47e-10 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs7647973 0.925 rs6446256 chr3:49224210 A/G cg20833759 chr3:49053208 WDR6;DALRD3 0.54 8.3 0.42 2.65e-15 Menarche (age at onset); CRC trans rs1656966 1.000 rs1656966 chr3:186466252 C/T cg26949087 chr2:26467503 HADHB;HADHA 0.42 6.1 0.32 3.06e-9 Myopia (pathological); CRC trans rs61931739 0.534 rs2389276 chr12:34097891 T/C cg26384229 chr12:38710491 ALG10B 0.52 7.23 0.37 3.4e-12 Morning vs. evening chronotype; CRC cis rs4481887 0.927 rs10788765 chr1:248445642 A/G cg13385794 chr1:248469461 NA -0.38 -6.59 -0.34 1.76e-10 Common traits (Other); CRC cis rs13191362 1.000 rs34653853 chr6:163114362 C/T cg21926612 chr6:163149169 PACRG;PARK2 0.98 12.77 0.58 1.37e-30 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs875971 0.862 rs6460293 chr7:65810192 C/A cg12463550 chr7:65579703 CRCP -0.5 -6.8 -0.35 4.92e-11 Aortic root size; CRC cis rs10504229 0.683 rs11787247 chr8:58131528 G/T cg21724239 chr8:58056113 NA 0.49 6.81 0.35 4.75e-11 Developmental language disorder (linguistic errors); CRC cis rs6860806 0.507 rs2631369 chr5:131705266 G/C cg04518342 chr5:131593106 PDLIM4 -0.44 -7.43 -0.38 9.63e-13 Breast cancer; CRC cis rs17092148 0.887 rs6059928 chr20:33167349 A/G cg08999081 chr20:33150536 PIGU 0.5 6.45 0.33 4.05e-10 Neuroticism; CRC cis rs96067 0.711 rs737381 chr1:36621186 G/C cg24686825 chr1:36642396 MAP7D1 -0.49 -6.3 -0.33 9.61e-10 Corneal structure; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg20503117 chr3:5164013 ARL8B 0.57 8.24 0.41 4.28e-15 Response to antipsychotic treatment; CRC trans rs11722228 0.549 rs73212830 chr4:10078759 A/T cg26043149 chr18:55253948 FECH 1.13 17.0 0.68 5.86e-47 Gout;Urate levels;Serum uric acid levels; CRC cis rs2228479 0.764 rs35518096 chr16:89961140 C/A cg06558623 chr16:89946397 TCF25 0.79 8.65 0.43 2.34e-16 Skin colour saturation; CRC cis rs2976388 0.573 rs1529865 chr8:143789171 C/T cg15511327 chr8:143859410 LYNX1 0.41 7.41 0.38 1.06e-12 Urinary tract infection frequency; CRC cis rs5769765 0.862 rs9616384 chr22:50313082 C/T cg04121214 chr22:50244548 NA 0.42 5.89 0.31 9.4e-9 Schizophrenia; CRC cis rs6570726 0.967 rs373527 chr6:145801861 C/T cg05347473 chr6:146136440 FBXO30 0.37 5.87 0.31 1.04e-8 Lobe attachment (rater-scored or self-reported); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg21685218 chr6:143771971 PEX3;ADAT2 0.43 6.22 0.32 1.52e-9 Intelligence (multi-trait analysis); CRC cis rs7172809 0.643 rs4886874 chr15:77838086 A/C cg10437265 chr15:77819839 NA 0.37 5.96 0.31 6.38e-9 Glucose homeostasis traits; CRC cis rs2404602 0.583 rs11072580 chr15:76540231 G/A cg22467129 chr15:76604101 ETFA -0.49 -8.61 -0.43 3.08e-16 Blood metabolite levels; CRC cis rs4076764 0.846 rs10753616 chr1:163415855 G/T cg06092702 chr1:163392909 NA 0.53 8.7 0.43 1.58e-16 Motion sickness; CRC cis rs73195822 0.667 rs57302533 chr12:111245613 A/C cg12870014 chr12:110450643 ANKRD13A 0.65 5.69 0.3 2.88e-8 Itch intensity from mosquito bite; CRC cis rs7811142 1.000 rs6975514 chr7:100056220 T/C cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.19 17.58 0.7 2.92e-49 Platelet count; CRC cis rs9611565 0.512 rs5996063 chr22:42168767 G/A cg03806693 chr22:41940476 POLR3H 1.11 13.62 0.6 8.15e-34 Vitiligo; CRC cis rs6499255 0.951 rs11639947 chr16:69646122 C/T cg15192750 chr16:69999425 NA 0.6 8.0 0.4 2.12e-14 IgE levels; CRC cis rs6712932 0.962 rs2053241 chr2:105842228 G/A cg22878388 chr2:105853796 NA -0.36 -6.81 -0.35 4.65e-11 Type 2 diabetes; CRC cis rs9894429 0.646 rs7405870 chr17:79617284 G/A cg18240062 chr17:79603768 NPLOC4 0.47 7.25 0.37 3.08e-12 Eye color traits; CRC cis rs6951245 1.000 rs78523927 chr7:1089458 T/C cg26224354 chr7:1096374 C7orf50;GPR146 -0.94 -11.87 -0.55 2.79e-27 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs909674 0.818 rs5750830 chr22:39840828 C/A cg11247378 chr22:39784982 NA -0.37 -6.61 -0.34 1.52e-10 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; CRC cis rs929354 0.772 rs1182441 chr7:157026650 A/G cg17757837 chr7:157058334 UBE3C -0.75 -12.98 -0.58 2.18e-31 Body mass index; CRC cis rs73200209 0.744 rs17426718 chr12:116599676 A/C cg01776926 chr12:116560359 MED13L -0.62 -7.14 -0.37 5.98e-12 Total body bone mineral density; CRC cis rs28386778 0.863 rs2727288 chr17:61901197 T/A cg06601766 chr17:61851465 DDX42;CCDC47 0.44 5.96 0.31 6.33e-9 Prudent dietary pattern; CRC cis rs4268898 0.552 rs7560342 chr2:24371691 T/C cg06627628 chr2:24431161 ITSN2 0.45 6.89 0.36 2.87e-11 Asthma; CRC cis rs4253772 0.591 rs8143066 chr22:46656607 C/T cg03482458 chr22:46692211 CN5H6.4;GTSE1 0.52 6.99 0.36 1.51e-11 LDL cholesterol;Cholesterol, total; CRC cis rs3820068 0.603 rs72647120 chr1:15956769 G/T cg24675056 chr1:15929824 NA 0.49 6.79 0.35 5.33e-11 Systolic blood pressure; CRC cis rs7811142 1.000 rs67315960 chr7:100015124 A/G cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.75 10.19 0.49 2.27e-21 Platelet count; CRC trans rs116095464 0.558 rs55664502 chr5:270485 T/C cg00938859 chr5:1591904 SDHAP3 0.68 7.59 0.39 3.39e-13 Breast cancer; CRC cis rs1707322 1.000 rs7526369 chr1:46390560 G/C cg06784218 chr1:46089804 CCDC17 0.51 8.98 0.44 2.07e-17 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs6121246 0.821 rs6058448 chr20:30332396 C/T cg13852791 chr20:30311386 BCL2L1 0.67 10.95 0.52 5.48e-24 Mean corpuscular hemoglobin; CRC cis rs6540556 0.954 rs7536882 chr1:209936673 C/G cg23920097 chr1:209922102 NA -0.53 -6.67 -0.35 1.06e-10 Red blood cell count; CRC cis rs10924970 0.967 rs12741262 chr1:235406849 T/C cg26050004 chr1:235667680 B3GALNT2 0.39 5.79 0.3 1.64e-8 Asthma; CRC cis rs9858542 0.953 rs9811982 chr3:49624377 A/C cg07274523 chr3:49395745 GPX1 0.47 6.11 0.32 2.77e-9 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs10504229 1.000 rs72650899 chr8:58180525 G/T cg24829409 chr8:58192753 C8orf71 -0.68 -11.34 -0.53 2.27e-25 Developmental language disorder (linguistic errors); CRC cis rs9322193 0.923 rs9480031 chr6:150080011 A/C cg00933542 chr6:150070202 PCMT1 0.33 6.97 0.36 1.73e-11 Lung cancer; CRC cis rs2952156 1.000 rs2934971 chr17:37854507 G/T cg11212589 chr17:38028394 ZPBP2 0.37 6.28 0.33 1.07e-9 Asthma; CRC cis rs7178572 1.000 rs11633054 chr15:77747276 A/G cg22256960 chr15:77711686 NA -0.65 -9.7 -0.47 1.02e-19 Type 2 diabetes; CRC cis rs6499255 0.951 rs60472033 chr16:69677709 A/G cg04110750 chr16:69646130 NFAT5 -0.55 -7.51 -0.38 5.71e-13 IgE levels; CRC cis rs7726839 0.540 rs72703092 chr5:599269 G/A cg16447950 chr5:562315 NA -0.74 -9.79 -0.47 4.96e-20 Obesity-related traits; CRC cis rs428668 0.523 rs10060607 chr5:150679304 A/C cg11125805 chr5:150678162 SLC36A3 0.63 11.94 0.55 1.47e-27 Skin aging (microtopography measurement); CRC cis rs1448094 0.512 rs11117061 chr12:86250916 G/A cg19622623 chr12:86230825 RASSF9 -0.41 -6.59 -0.34 1.7e-10 Major depressive disorder; CRC cis rs9902453 0.967 rs1906451 chr17:28515479 A/G cg26525008 chr17:28256777 EFCAB5;SSH2 0.56 8.38 0.42 1.61e-15 Coffee consumption (cups per day); CRC cis rs9486719 1.000 rs2971603 chr6:97035418 C/T cg18709589 chr6:96969512 KIAA0776 -0.46 -5.93 -0.31 7.72e-9 Migraine;Coronary artery disease; CRC trans rs9956878 0.555 rs8085188 chr18:73544676 A/G cg14165241 chr9:131315156 SPTAN1 -0.38 -6.14 -0.32 2.43e-9 Obesity-related traits; CRC cis rs9467711 0.591 rs3752417 chr6:26045905 G/C cg08501292 chr6:25962987 TRIM38 0.91 8.57 0.43 4.05e-16 Autism spectrum disorder or schizophrenia; CRC trans rs4332037 0.552 rs11773627 chr7:2002733 A/G cg11693508 chr17:37793320 STARD3 0.5 6.06 0.32 3.67e-9 Bipolar disorder; CRC cis rs447735 0.507 rs11645271 chr16:89729125 G/T cg01097406 chr16:89675127 NA -0.38 -7.19 -0.37 4.45e-12 Hemoglobin concentration; CRC cis rs59918340 0.728 rs10112337 chr8:142233573 A/G cg23750338 chr8:142222470 SLC45A4 -0.61 -11.06 -0.52 2.12e-24 Immature fraction of reticulocytes; CRC cis rs7811142 0.943 rs28578163 chr7:100044754 A/G cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.91 12.61 0.57 5.01e-30 Platelet count; CRC cis rs9910055 0.530 rs11656758 chr17:42301541 A/G cg13607699 chr17:42295918 UBTF 0.82 14.4 0.62 8.3e-37 Total body bone mineral density; CRC cis rs1008375 1.000 rs4698635 chr4:17630242 C/A cg16339924 chr4:17578868 LAP3 0.53 7.13 0.37 6.26e-12 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs2762353 0.538 rs35670731 chr6:25728235 C/T cg03517284 chr6:25882590 NA 0.76 10.78 0.51 2.12e-23 Blood metabolite levels; CRC trans rs7937682 0.855 rs571462 chr11:111487106 C/G cg18187862 chr3:45730750 SACM1L 0.45 6.55 0.34 2.23e-10 Primary sclerosing cholangitis; CRC cis rs7493 1.000 rs2299264 chr7:95046708 C/T cg07404485 chr7:94953653 PON1 -0.46 -6.25 -0.33 1.26e-9 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs6502050 0.835 rs4789731 chr17:80145904 C/T cg09264619 chr17:80180166 NA -0.35 -5.81 -0.31 1.48e-8 Life satisfaction; CRC cis rs2070488 0.965 rs1058945 chr3:38532511 A/G cg01465620 chr3:38496096 LOC100128640;ACVR2B -0.91 -17.16 -0.69 1.42e-47 Electrocardiographic conduction measures; CRC cis rs7584330 0.554 rs77194105 chr2:238436463 T/C cg08992911 chr2:238395768 MLPH 0.61 6.19 0.32 1.8e-9 Prostate cancer; CRC cis rs1448094 0.740 rs4919774 chr12:86337560 G/T cg18827107 chr12:86230957 RASSF9 -0.43 -6.83 -0.35 4.16e-11 Major depressive disorder; CRC cis rs6460942 0.915 rs75158182 chr7:12456059 C/T cg06484146 chr7:12443880 VWDE -0.78 -8.1 -0.41 1.11e-14 Coronary artery disease; CRC cis rs10078 0.515 rs890984 chr5:479540 A/G cg26072250 chr5:443457 EXOC3;C5orf55 0.58 5.79 0.3 1.66e-8 Fat distribution (HIV); CRC cis rs6502050 0.835 rs4789731 chr17:80145904 C/T cg02741985 chr17:80059408 CCDC57 0.44 7.33 0.37 1.76e-12 Life satisfaction; CRC cis rs6963495 0.818 rs73190202 chr7:105166510 A/G cg02135003 chr7:105160482 PUS7 -0.91 -12.41 -0.56 2.87e-29 Bipolar disorder (body mass index interaction); CRC cis rs6685188 0.920 rs6676110 chr1:205662977 G/A cg24503407 chr1:205819492 PM20D1 -0.45 -6.17 -0.32 2.04e-9 White blood cell count (basophil);Basophil percentage of white cells; CRC cis rs7586879 0.593 rs10200566 chr2:25130462 G/T cg04586622 chr2:25135609 ADCY3 0.54 9.95 0.48 1.49e-20 Body mass index; CRC cis rs9527 0.662 rs4919687 chr10:104595248 G/A cg15744005 chr10:104629667 AS3MT -0.34 -6.28 -0.33 1.07e-9 Arsenic metabolism; CRC cis rs172166 0.694 rs1631552 chr6:28089699 C/A cg03623178 chr6:28175578 NA 0.79 11.66 0.54 1.54e-26 Cardiac Troponin-T levels; CRC cis rs1129187 0.934 rs9471974 chr6:42918984 T/A cg27588902 chr6:42928151 GNMT -0.38 -6.8 -0.35 5.09e-11 Alzheimer's disease in APOE e4+ carriers; CRC cis rs7224737 0.957 rs6503687 chr17:40295397 G/A cg00647820 chr17:40259828 DHX58 -0.46 -6.5 -0.34 3.04e-10 Fibrinogen levels; CRC cis rs9747201 1.000 rs9747668 chr17:80161081 A/G cg09264619 chr17:80180166 NA -0.49 -7.13 -0.37 6.39e-12 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs2880765 0.631 rs55767890 chr15:86004142 C/G cg10818794 chr15:86012489 AKAP13 -0.5 -7.83 -0.4 6.6e-14 Coronary artery disease; CRC cis rs7552404 0.691 rs5745449 chr1:76344711 A/T cg22875332 chr1:76189707 ACADM -0.59 -7.38 -0.38 1.3e-12 Blood metabolite levels;Acylcarnitine levels; CRC cis rs2731664 0.792 rs335466 chr5:176889530 C/A cg23176889 chr5:176863531 GRK6 -0.74 -15.92 -0.66 1.08e-42 Intelligence (multi-trait analysis); CRC cis rs59698941 0.527 rs1557852 chr5:132181800 G/A cg14825688 chr5:132208181 LEAP2 -0.37 -5.88 -0.31 9.93e-9 Apolipoprotein A-IV levels; CRC cis rs10504229 1.000 rs67384205 chr8:58180348 C/G cg02290350 chr8:58132656 NA -0.42 -5.96 -0.31 6.62e-9 Developmental language disorder (linguistic errors); CRC cis rs4819052 0.851 rs7276828 chr21:46695039 T/G cg19498844 chr21:46707878 POFUT2;LOC642852 0.79 11.53 0.54 4.61e-26 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC trans rs7618501 0.633 rs2883057 chr3:49998282 C/T cg21665057 chr3:196295764 WDR53;FBXO45 0.6 9.43 0.46 7.6e-19 Intelligence (multi-trait analysis); CRC cis rs875971 0.545 rs801199 chr7:66025273 A/G cg18876405 chr7:65276391 NA -0.44 -6.19 -0.32 1.82e-9 Aortic root size; CRC cis rs7727544 0.507 rs9791170 chr5:131569627 A/G cg02033258 chr5:131593261 PDLIM4 0.44 8.27 0.41 3.33e-15 Blood metabolite levels; CRC cis rs56104184 0.830 rs55966626 chr19:49342396 G/T cg15549821 chr19:49342101 PLEKHA4 -0.84 -9.12 -0.45 7.44e-18 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; CRC cis rs9462027 0.675 rs7755926 chr6:34722574 A/C cg07306190 chr6:34760872 UHRF1BP1 -0.36 -6.49 -0.34 3.21e-10 Systemic lupus erythematosus; CRC cis rs2408955 0.541 rs11168428 chr12:48547128 A/G cg00601486 chr12:48723148 H1FNT -0.35 -6.71 -0.35 8.75e-11 Glycated hemoglobin levels; CRC cis rs9329289 0.510 rs2029604 chr10:2554700 T/C cg15501526 chr10:2543763 NA 0.48 8.92 0.44 3.28e-17 Age-related hearing impairment; CRC cis rs34172651 0.517 rs34172679 chr16:24840381 C/T cg02428538 chr16:24856791 SLC5A11 -0.6 -6.83 -0.35 4.01e-11 Intelligence (multi-trait analysis); CRC cis rs9311474 0.508 rs6786919 chr3:52599789 A/G cg15147215 chr3:52552868 STAB1 -0.65 -11.29 -0.53 3.36e-25 Electroencephalogram traits; CRC cis rs1150668 0.796 rs1124132 chr6:28380321 T/G cg21251018 chr6:28226885 NKAPL 0.53 9.1 0.45 9.15e-18 Pubertal anthropometrics; CRC cis rs11679072 1.000 rs11688828 chr2:240453890 T/C cg03276489 chr2:240449683 NA -0.9 -7.37 -0.38 1.39e-12 Blood pressure (smoking interaction); CRC cis rs11148252 0.532 rs9536190 chr13:53181044 T/C cg20354231 chr13:53171401 NA -0.54 -8.1 -0.41 1.11e-14 Lewy body disease; CRC cis rs4072980 0.524 rs28442147 chr1:38395410 T/A cg12658694 chr1:38397304 INPP5B 0.5 7.09 0.36 8.21e-12 Coronary artery disease; CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg04393675 chr16:28986095 SPNS1 0.41 6.65 0.34 1.24e-10 Obesity-related traits; CRC cis rs2991971 0.967 rs60608374 chr1:46008913 G/A cg03123370 chr1:45965343 CCDC163P;MMACHC -0.39 -5.91 -0.31 8.73e-9 High light scatter reticulocyte count; CRC cis rs7626444 0.625 rs1403101 chr3:196485074 G/A cg12930392 chr3:196481615 PAK2 0.39 7.11 0.36 7.25e-12 Monocyte count; CRC cis rs3087591 0.708 rs2525568 chr17:29675878 T/G cg24425628 chr17:29625626 OMG;NF1 0.72 13.29 0.59 1.44e-32 Hip circumference; CRC cis rs4975616 0.869 rs467095 chr5:1336221 T/C cg26373071 chr5:1325741 CLPTM1L 0.55 10.04 0.48 7.37e-21 Lung cancer; CRC cis rs2288073 0.965 rs10469924 chr2:24416230 G/A cg06627628 chr2:24431161 ITSN2 -0.71 -9.9 -0.48 2.12e-20 Venous thromboembolism (SNP x SNP interaction); CRC cis rs853679 0.517 rs3173443 chr6:28137027 T/G cg18032046 chr6:28092343 ZSCAN16 -0.51 -5.93 -0.31 7.47e-9 Depression; CRC cis rs4713118 0.955 rs9380011 chr6:27683924 A/G cg15845792 chr6:28175446 NA 0.6 7.95 0.4 3.01e-14 Parkinson's disease; CRC cis rs9768139 0.733 rs34173461 chr7:158122175 C/G cg06219351 chr7:158114137 PTPRN2 -0.54 -8.12 -0.41 9.77e-15 Calcium levels; CRC cis rs10751667 0.621 rs7394862 chr11:927500 T/C cg23136738 chr11:925521 AP2A2 -0.41 -6.8 -0.35 4.92e-11 Alzheimer's disease (late onset); CRC cis rs9322193 0.923 rs9479094 chr6:150046219 C/T cg13206674 chr6:150067644 NUP43 0.64 9.48 0.46 5.28e-19 Lung cancer; CRC cis rs853679 0.542 rs34131763 chr6:28075000 A/C cg02683197 chr6:28174875 NA 0.82 10.05 0.48 6.9e-21 Depression; CRC cis rs1448094 0.512 rs7957170 chr12:86243282 A/G cg25456477 chr12:86230367 RASSF9 0.32 5.67 0.3 3.13e-8 Major depressive disorder; CRC cis rs9925964 0.744 rs12716979 chr16:31011821 T/G cg03418659 chr16:31128414 MYST1 0.44 6.55 0.34 2.26e-10 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs172166 0.694 rs203892 chr6:28067196 T/C cg10876282 chr6:28092338 ZSCAN16 0.5 6.72 0.35 7.89e-11 Cardiac Troponin-T levels; CRC trans rs1814175 0.817 rs7950856 chr11:49976394 C/T cg15704280 chr7:45808275 SEPT13 -1.02 -20.61 -0.75 3.5e-61 Height; CRC cis rs4363385 0.588 rs6698361 chr1:153023184 T/G cg25856811 chr1:152973957 SPRR3 -0.23 -6.17 -0.32 2.01e-9 Inflammatory skin disease; CRC cis rs6500602 0.702 rs2270366 chr16:4558615 A/G cg08645402 chr16:4508243 NA -0.63 -11.23 -0.53 5.3e-25 Schizophrenia; CRC cis rs514406 0.861 rs7513052 chr1:53241360 C/T cg25767906 chr1:53392781 SCP2 0.4 6.54 0.34 2.36e-10 Monocyte count; CRC trans rs2727020 0.718 rs1404366 chr11:49415899 T/A cg11707556 chr5:10655725 ANKRD33B -0.37 -5.97 -0.31 6.15e-9 Coronary artery disease; CRC cis rs12594515 1.000 rs6493176 chr15:45990026 A/G cg06207120 chr15:45996521 NA 0.32 7.75 0.39 1.14e-13 Waist circumference;Weight; CRC trans rs1933755 0.614 rs6569693 chr6:130924497 A/G cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 0.79 6.0 0.31 5.35e-9 Colorectal cancer (calcium intake interaction); CRC trans rs3960554 0.808 rs111714534 chr7:75748896 C/T cg19862616 chr7:65841803 NCRNA00174 0.77 8.82 0.44 6.83e-17 Eotaxin levels; CRC cis rs1005277 0.522 rs9417256 chr10:37976990 A/G cg00409905 chr10:38381863 ZNF37A -0.65 -10.73 -0.51 3.1e-23 Extrinsic epigenetic age acceleration; CRC cis rs7615952 0.611 rs2947646 chr3:125593602 C/T cg05084668 chr3:125655381 ALG1L 0.67 8.56 0.43 4.46e-16 Blood pressure (smoking interaction); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg24879809 chr1:92351641 TGFBR3 0.42 6.77 0.35 6.04e-11 Liver disease severity in Alagille syndrome; CRC cis rs1003719 0.680 rs2835668 chr21:38580151 C/G cg10648535 chr21:38446584 PIGP;TTC3 -0.45 -6.23 -0.32 1.41e-9 Eye color traits; CRC trans rs61931739 0.534 rs28548399 chr12:34188151 G/A cg26384229 chr12:38710491 ALG10B 0.54 6.88 0.35 2.99e-11 Morning vs. evening chronotype; CRC cis rs270601 0.683 rs81598 chr5:131587960 C/G cg20512303 chr5:131592959 PDLIM4 0.41 7.08 0.36 8.81e-12 Acylcarnitine levels; CRC cis rs6426558 0.502 rs10916080 chr1:227232040 A/G cg10327440 chr1:227177885 CDC42BPA 0.45 6.73 0.35 7.55e-11 Neutrophil percentage of white cells; CRC cis rs2153535 0.541 rs9328471 chr6:8468842 T/C cg21535247 chr6:8435926 SLC35B3 0.49 7.4 0.38 1.14e-12 Motion sickness; CRC cis rs6502050 0.769 rs9898542 chr17:80119682 C/T cg11859384 chr17:80120422 CCDC57 -0.36 -5.75 -0.3 2.06e-8 Life satisfaction; CRC cis rs7591163 1.000 rs7574255 chr2:228699884 C/G cg22079747 chr2:228736145 WDR69 0.42 5.69 0.3 2.8e-8 Blood pressure; CRC cis rs7107174 1.000 rs10899476 chr11:78051794 A/G cg02023728 chr11:77925099 USP35 0.5 7.73 0.39 1.34e-13 Testicular germ cell tumor; CRC cis rs7772486 0.686 rs9376961 chr6:146048737 C/T cg13319975 chr6:146136371 FBXO30 -0.45 -6.83 -0.35 4.11e-11 Lobe attachment (rater-scored or self-reported); CRC cis rs7772486 0.558 rs9497403 chr6:146054695 T/G cg23711669 chr6:146136114 FBXO30 -0.62 -9.09 -0.45 9.63e-18 Lobe attachment (rater-scored or self-reported); CRC cis rs7113874 0.569 rs9300091 chr11:8588823 G/A cg02811074 chr11:8615871 STK33 -0.35 -5.97 -0.31 6.17e-9 Body mass index in physically active individuals;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs6951245 0.872 rs76161580 chr7:1100307 G/T cg20603222 chr7:1096387 C7orf50;GPR146 -0.72 -8.66 -0.43 2.19e-16 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg13244260 chr10:112632027 LOC282997;PDCD4 0.44 6.17 0.32 1.99e-9 Response to antipsychotic treatment; CRC cis rs4268898 0.722 rs35520052 chr2:24415277 C/T cg06627628 chr2:24431161 ITSN2 0.48 7.17 0.37 4.88e-12 Asthma; CRC trans rs8097070 0.661 rs9966711 chr18:23171413 C/G cg03560053 chr19:9946083 PIN1 0.55 5.98 0.31 5.92e-9 Systemic juvenile idiopathic arthritis; CRC cis rs116095464 0.764 rs10069197 chr5:230822 G/C cg22857025 chr5:266934 NA -1.21 -16.46 -0.67 7.6e-45 Breast cancer; CRC cis rs2292884 0.505 rs11889660 chr2:238438395 C/T cg08992911 chr2:238395768 MLPH 0.59 6.09 0.32 3.2e-9 Prostate cancer; CRC cis rs4888262 0.545 rs8052923 chr16:74680105 C/T cg01733217 chr16:74700730 RFWD3 0.8 12.22 0.56 1.41e-28 Testicular germ cell tumor; CRC cis rs6500395 1.000 rs7202551 chr16:48728984 A/G cg04672837 chr16:48644449 N4BP1 -0.44 -6.31 -0.33 9.05e-10 Response to tocilizumab in rheumatoid arthritis; CRC cis rs7666738 0.830 rs34890015 chr4:99023769 A/T cg17366294 chr4:99064904 C4orf37 0.45 7.51 0.38 5.74e-13 Colonoscopy-negative controls vs population controls; CRC cis rs9814567 1.000 rs2177601 chr3:134245434 T/C cg06541857 chr3:134203789 ANAPC13;CEP63 0.39 5.74 0.3 2.15e-8 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs7781266 0.790 rs62469961 chr7:133150905 G/T cg03336402 chr7:133662267 EXOC4 0.5 5.91 0.31 8.72e-9 Educational attainment (college completion); CRC cis rs281302 0.621 rs395722 chr15:47731236 G/A cg13159054 chr15:47721715 NA -0.43 -6.45 -0.34 3.93e-10 Educational attainment (years of education);Cognitive ability (multi-trait analysis); CRC cis rs1790761 0.587 rs7934075 chr11:67295949 T/C cg00290607 chr11:67383545 NA -0.35 -6.02 -0.31 4.78e-9 Mean corpuscular volume; CRC cis rs9287719 0.649 rs6722126 chr2:10721642 A/G cg00105475 chr2:10696890 NA 0.43 6.8 0.35 5.06e-11 Prostate cancer; CRC cis rs7223966 1.000 rs17549954 chr17:61707032 A/G cg05941027 chr17:61774174 LIMD2 0.34 5.85 0.31 1.18e-8 Hip circumference adjusted for BMI;Body mass index; CRC cis rs4423214 0.879 rs1792281 chr11:71135496 G/A cg13043300 chr11:71146211 DHCR7 -0.46 -6.32 -0.33 8.37e-10 Vitamin D levels; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg06926254 chr16:29972939 TMEM219 0.47 6.81 0.35 4.74e-11 Thyroid stimulating hormone; CRC cis rs1448094 0.512 rs12305828 chr12:86249153 C/G cg19622623 chr12:86230825 RASSF9 -0.41 -6.76 -0.35 6.45e-11 Major depressive disorder; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg07925823 chr16:68298504 SLC7A6 0.44 6.13 0.32 2.56e-9 Anxiety disorder; CRC cis rs1218582 0.772 rs6656435 chr1:154876869 G/A cg09359103 chr1:154839909 KCNN3 -0.71 -12.5 -0.57 1.36e-29 Prostate cancer; CRC cis rs7937682 0.921 rs11213940 chr11:111433927 C/A cg19812747 chr11:111475976 SIK2 0.49 7.28 0.37 2.51e-12 Primary sclerosing cholangitis; CRC cis rs17001868 0.568 rs9611310 chr22:40733777 A/G cg07138101 chr22:40742427 ADSL 0.59 7.86 0.4 5.36e-14 Mammographic density (dense area); CRC cis rs9291683 0.704 rs11726271 chr4:10098192 G/A cg00071950 chr4:10020882 SLC2A9 -0.48 -8.24 -0.41 4e-15 Bone mineral density; CRC cis rs801193 0.591 rs4506088 chr7:66135457 G/A cg18252515 chr7:66147081 NA 0.44 6.22 0.32 1.5e-9 Aortic root size; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg07683663 chr4:147096828 LSM6 0.5 6.49 0.34 3.21e-10 Thyroid stimulating hormone; CRC cis rs6951245 0.872 rs113119264 chr7:1080564 G/A cg22907277 chr7:1156413 C7orf50 0.72 7.47 0.38 7.14e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs9747201 0.962 rs11656153 chr17:80072950 G/A cg14673194 chr17:80132900 CCDC57 0.49 6.28 0.33 1.07e-9 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs995000 0.868 rs1168102 chr1:63127705 C/T cg19896129 chr1:63156450 NA -0.42 -6.45 -0.34 3.91e-10 Triglyceride levels; CRC trans rs4698048 0.506 rs6833292 chr4:10272429 C/T cg26043149 chr18:55253948 FECH -0.46 -6.78 -0.35 5.58e-11 Skin aging (microtopography measurement); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg01434783 chr4:124319883 SPRY1 0.43 6.31 0.33 8.98e-10 Intelligence (multi-trait analysis); CRC cis rs1552244 1.000 rs6768102 chr3:10149380 A/G cg08888203 chr3:10149979 C3orf24 0.71 9.8 0.48 4.67e-20 Alzheimer's disease; CRC cis rs2795502 1.000 rs2795496 chr10:43337842 G/A cg27426351 chr10:43362370 NA -0.59 -7.05 -0.36 1.04e-11 Blood protein levels; CRC cis rs7666738 0.791 rs13125277 chr4:99009922 T/G cg17366294 chr4:99064904 C4orf37 0.44 7.39 0.38 1.19e-12 Colonoscopy-negative controls vs population controls; CRC cis rs8060686 0.858 rs11553287 chr16:67905407 A/G cg01951491 chr16:67709440 GFOD2 -0.45 -5.92 -0.31 8.22e-9 HDL cholesterol;Metabolic syndrome; CRC cis rs589448 0.902 rs2603089 chr12:69776800 C/T cg20891283 chr12:69753455 YEATS4 -0.98 -21.04 -0.76 6.92e-63 Cerebrospinal fluid biomarker levels; CRC cis rs10752881 1.000 rs4593781 chr1:182984983 C/T ch.1.3577855R chr1:183094577 LAMC1 0.86 15.22 0.64 5.91e-40 Colorectal cancer; CRC cis rs1003719 0.762 rs11701556 chr21:38455153 A/G cg10648535 chr21:38446584 PIGP;TTC3 0.51 7.26 0.37 2.78e-12 Eye color traits; CRC cis rs9527 0.615 rs7080462 chr10:104736699 T/C cg15744005 chr10:104629667 AS3MT -0.31 -6.12 -0.32 2.69e-9 Arsenic metabolism; CRC cis rs6543140 0.964 rs2160200 chr2:103033963 G/T cg03938978 chr2:103052716 IL18RAP 0.46 7.22 0.37 3.7e-12 Blood protein levels; CRC cis rs9914988 0.943 rs9894335 chr17:27138483 C/A cg20469991 chr17:27169893 C17orf63 -0.6 -7.3 -0.37 2.15e-12 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs4728302 0.869 rs10231102 chr7:133573310 G/A cg03336402 chr7:133662267 EXOC4 -0.41 -5.87 -0.31 1.05e-8 Intelligence;Intelligence (multi-trait analysis); CRC cis rs2439831 0.850 rs7169988 chr15:44060435 T/C cg02155558 chr15:43621948 ADAL;LCMT2 0.69 7.59 0.39 3.25e-13 Lung cancer in ever smokers; CRC cis rs60843830 0.596 rs17041320 chr2:112051 A/G cg00108164 chr2:264199 ACP1;SH3YL1 0.39 5.62 0.3 4.15e-8 Spherical equivalent (joint analysis main effects and education interaction); CRC trans rs2303319 0.504 rs62189054 chr2:162624654 C/G cg22902534 chr3:183892754 AP2M1 -0.7 -6.07 -0.32 3.56e-9 Cognitive function; CRC cis rs2882667 0.898 rs13163536 chr5:138377219 A/G cg04439458 chr5:138467593 SIL1 -0.33 -5.99 -0.31 5.44e-9 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs6912958 0.712 rs6454640 chr6:88370352 G/T cg12350822 chr6:88032061 C6orf162;GJB7 0.33 6.26 0.33 1.19e-9 Monocyte percentage of white cells; CRC cis rs7618915 0.621 rs6788993 chr3:52605136 T/C cg10802521 chr3:52805072 NEK4 -0.59 -9.25 -0.45 2.89e-18 Bipolar disorder; CRC cis rs3806843 0.548 rs246057 chr5:140325583 A/G cg19875535 chr5:140030758 IK 0.39 6.02 0.31 4.67e-9 Depressive symptoms (multi-trait analysis); CRC cis rs644799 0.965 rs10831425 chr11:95500628 T/C cg25478527 chr11:95522999 CEP57;FAM76B 0.52 7.56 0.38 3.99e-13 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs9916302 0.904 rs585961 chr17:37444036 G/A cg03013999 chr17:37608204 MED1 -0.48 -7.52 -0.38 5.37e-13 Glomerular filtration rate (creatinine); CRC cis rs12477438 0.765 rs2309454 chr2:99595418 G/A cg26064155 chr2:99771622 LIPT1;TSGA10 -0.63 -8.56 -0.43 4.4e-16 Chronic sinus infection; CRC cis rs9372498 0.536 rs9489394 chr6:118758234 T/C cg07617317 chr6:118971624 C6orf204 0.52 6.47 0.34 3.53e-10 Diastolic blood pressure; CRC cis rs7208859 0.673 rs216418 chr17:28936537 G/A cg26176469 chr17:28951361 LRRC37B2 0.54 5.92 0.31 7.94e-9 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs375066 0.526 rs17712224 chr19:44331594 A/C cg19542119 chr19:44331823 ZNF283 0.41 5.74 0.3 2.1e-8 Breast cancer; CRC trans rs3780486 0.834 rs75443249 chr9:33149207 A/G cg04842962 chr6:43655489 MRPS18A 1.01 15.73 0.66 5.97e-42 IgG glycosylation; CRC cis rs7945705 0.818 rs2742537 chr11:8908389 G/A cg12365402 chr11:9010492 NRIP3 -0.54 -9.81 -0.48 4.26e-20 Hemoglobin concentration; CRC trans rs10842750 1.000 rs10842750 chr12:26690565 G/T cg21097354 chr7:27179161 NA 0.31 6.59 0.34 1.75e-10 Kashin-Beck disease; CRC cis rs11105298 0.891 rs10858852 chr12:89833338 T/C cg08166232 chr12:89918718 WDR51B;GALNT4 -0.61 -7.74 -0.39 1.27e-13 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; CRC cis rs4474465 1.000 rs4944200 chr11:78166930 C/A cg27205649 chr11:78285834 NARS2 -0.48 -5.89 -0.31 9.45e-9 Alzheimer's disease (survival time); CRC cis rs801193 0.636 rs10233806 chr7:66118248 G/C cg12463550 chr7:65579703 CRCP -0.47 -6.49 -0.34 3.1e-10 Aortic root size; CRC cis rs35306767 0.855 rs12774985 chr10:904245 C/T cg20503657 chr10:835505 NA 1.23 14.95 0.64 6.45e-39 Eosinophil percentage of granulocytes; CRC cis rs4713118 0.513 rs149950 chr6:28033039 T/G cg15786705 chr6:28176104 NA 0.59 8.5 0.42 6.86e-16 Parkinson's disease; CRC cis rs13191362 1.000 rs35449999 chr6:163023465 A/G cg06582575 chr6:163149167 PACRG;PARK2 0.76 10.09 0.49 4.92e-21 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg24261177 chr8:96281885 C8orf37 0.42 6.01 0.31 5.04e-9 Response to antipsychotic treatment; CRC cis rs57561814 0.655 rs58879058 chr7:22741822 T/C cg26061582 chr7:22766209 IL6 0.78 6.38 0.33 6e-10 Tonsillectomy; CRC cis rs10504073 0.584 rs11784268 chr8:49956339 T/G cg00325661 chr8:49890786 NA 0.59 10.66 0.51 5.37e-23 Blood metabolite ratios; CRC cis rs4692589 0.606 rs11943813 chr4:170938243 T/C cg19918862 chr4:170955249 NA 0.53 6.99 0.36 1.57e-11 Anxiety disorder; CRC trans rs3942852 0.806 rs4752807 chr11:48128751 T/G cg15704280 chr7:45808275 SEPT13 -0.61 -7.89 -0.4 4.6e-14 Acute lymphoblastic leukemia (childhood); CRC cis rs7584330 0.740 rs12471291 chr2:238441751 T/G cg14458575 chr2:238380390 NA 0.51 8.96 0.44 2.39e-17 Prostate cancer; CRC cis rs7772486 0.641 rs2777485 chr6:146334377 G/A cg05347473 chr6:146136440 FBXO30 0.45 6.44 0.33 4.36e-10 Lobe attachment (rater-scored or self-reported); CRC cis rs6741892 0.536 rs13024840 chr2:38895920 T/A cg00359181 chr2:38893519 GALM -0.55 -6.25 -0.33 1.28e-9 5-HTT brain serotonin transporter levels; CRC cis rs2836974 0.966 rs7283516 chr21:40690537 A/G cg17971929 chr21:40555470 PSMG1 0.75 10.32 0.49 7.97e-22 Cognitive function; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg03459953 chr6:53659983 LRRC1 0.45 5.97 0.31 6.07e-9 Anxiety disorder; CRC cis rs763121 0.853 rs5757193 chr22:39034867 A/G cg06544989 chr22:39130855 UNC84B -0.43 -6.26 -0.33 1.17e-9 Menopause (age at onset); CRC cis rs7312933 1.000 rs7312933 chr12:42503467 C/T cg11827402 chr12:42719852 PPHLN1;ZCRB1 -0.6 -7.74 -0.39 1.24e-13 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CRC cis rs41005 1.000 rs193931 chr2:8107435 A/G cg03155496 chr2:8117019 LOC339788 -0.41 -7.38 -0.38 1.34e-12 Response to anti-TNF therapy in rheumatoid arthritis; CRC cis rs3087591 1.000 rs2905800 chr17:29531980 A/G cg24425628 chr17:29625626 OMG;NF1 0.83 16.15 0.67 1.25e-43 Hip circumference; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg22005393 chr7:102985332 DNAJC2 0.44 6.53 0.34 2.45e-10 Intelligence (multi-trait analysis); CRC cis rs2380220 0.938 rs6923253 chr6:95970141 C/G cg04719120 chr6:96025338 MANEA 0.61 6.98 0.36 1.67e-11 Behavioural disinhibition (generation interaction); CRC cis rs6964587 0.692 rs4729021 chr7:91758422 C/A cg17063962 chr7:91808500 NA 0.61 9.71 0.47 9.35e-20 Breast cancer; CRC cis rs12701220 0.744 rs2030958 chr7:1076010 G/T cg26240231 chr7:1148101 C7orf50 -0.47 -6.37 -0.33 6.23e-10 Bronchopulmonary dysplasia; CRC cis rs6951245 1.000 rs1881123 chr7:1084706 C/T cg26224354 chr7:1096374 C7orf50;GPR146 -0.89 -11.23 -0.53 5.33e-25 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs734999 0.545 rs4474198 chr1:2553758 C/T cg20673091 chr1:2541236 MMEL1 0.36 5.8 0.3 1.55e-8 Ulcerative colitis; CRC cis rs3889199 0.594 rs2026954 chr1:59687055 T/C cg25881383 chr1:59680599 NA -0.37 -5.98 -0.31 5.85e-9 Pulse pressure; CRC cis rs929596 0.755 rs3771341 chr2:234673239 G/A cg02227331 chr2:234663937 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 0.43 6.21 0.32 1.62e-9 Total bilirubin levels in HIV-1 infection; CRC cis rs8031584 0.505 rs2959036 chr15:31219742 T/G cg14829155 chr15:31115871 NA 0.36 5.76 0.3 1.89e-8 Huntington's disease progression; CRC cis rs3106136 0.609 rs11097407 chr4:95146135 C/G cg11021082 chr4:95130006 SMARCAD1 -0.46 -6.69 -0.35 9.43e-11 Capecitabine sensitivity; CRC trans rs459571 1.000 rs456207 chr9:136911140 G/A cg15028160 chr19:49622717 PPFIA3;C19orf73 -0.56 -7.23 -0.37 3.49e-12 Platelet distribution width; CRC cis rs3806843 1.000 rs1548701 chr5:140164557 T/C cg16607685 chr5:140181889 PCDHA2;PCDHA1;PCDHA3 -0.26 -5.92 -0.31 8.06e-9 Depressive symptoms (multi-trait analysis); CRC cis rs7705042 0.828 rs1036209 chr5:141498632 T/A cg08523384 chr5:141488047 NDFIP1 -0.34 -5.95 -0.31 6.98e-9 Asthma; CRC cis rs897984 0.542 rs73530203 chr16:31099859 G/A cg02466173 chr16:30829666 NA -0.59 -8.57 -0.43 4.04e-16 Dementia with Lewy bodies; CRC cis rs796364 1.000 rs166845 chr2:200823360 T/A cg25936922 chr2:200820526 C2orf60;C2orf47 0.71 7.78 0.39 9.18e-14 Schizophrenia; CRC cis rs9837602 0.507 rs1059905 chr3:99516879 A/T cg07805332 chr3:99536008 MIR548G;C3orf26 0.4 6.21 0.32 1.63e-9 Breast cancer; CRC cis rs7917772 0.582 rs729024 chr10:104341975 T/C cg11453585 chr10:104263688 ACTR1A;SUFU 0.82 15.29 0.64 3.08e-40 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC cis rs2200578 1.000 rs72954221 chr2:99899445 T/C cg26064155 chr2:99771622 LIPT1;TSGA10 0.56 6.45 0.33 4.1e-10 IgG glycosylation; CRC trans rs1499614 1.000 rs2659911 chr7:66158420 G/A cg10756647 chr7:56101905 PSPH 0.77 8.1 0.41 1.09e-14 Gout; CRC cis rs6570726 0.577 rs441982 chr6:145842848 A/G cg13319975 chr6:146136371 FBXO30 -0.62 -9.21 -0.45 3.82e-18 Lobe attachment (rater-scored or self-reported); CRC cis rs4253772 0.513 rs6008597 chr22:46703904 A/C cg03482458 chr22:46692211 CN5H6.4;GTSE1 0.49 6.26 0.33 1.17e-9 LDL cholesterol;Cholesterol, total; CRC cis rs12144309 0.554 rs2476602 chr1:114396955 C/T cg03325407 chr1:114423726 BCL2L15 0.35 6.5 0.34 2.99e-10 Coronary artery disease; CRC cis rs4481887 0.504 rs7530153 chr1:248357891 T/C cg00666640 chr1:248458726 OR2T12 0.43 7.04 0.36 1.15e-11 Common traits (Other); CRC cis rs28655083 0.826 rs2134335 chr16:77079272 A/G cg01753188 chr16:77233325 SYCE1L;MON1B -0.55 -6.41 -0.33 5.04e-10 Lobe attachment (rater-scored or self-reported); CRC cis rs4654899 1.000 rs6669102 chr1:21355543 A/G cg02927042 chr1:21476669 EIF4G3 -0.48 -7.76 -0.39 1.05e-13 Superior frontal gyrus grey matter volume; CRC cis rs9911578 1.000 rs2333332 chr17:56631054 A/G cg05425664 chr17:57184151 TRIM37 0.52 8.21 0.41 4.94e-15 Intelligence (multi-trait analysis); CRC trans rs9329221 0.597 rs17751178 chr8:10116730 A/G cg06636001 chr8:8085503 FLJ10661 0.54 7.99 0.4 2.24e-14 Neuroticism; CRC trans rs1814175 0.645 rs1851853 chr11:49953434 C/T cg15704280 chr7:45808275 SEPT13 -0.94 -16.88 -0.68 1.75e-46 Height; CRC cis rs9322193 0.886 rs9485408 chr6:149940024 T/C cg00933542 chr6:150070202 PCMT1 0.29 6.05 0.32 3.94e-9 Lung cancer; CRC cis rs6582630 0.502 rs11504451 chr12:38425294 G/A cg13010199 chr12:38710504 ALG10B 0.45 5.94 0.31 7.1e-9 Drug-induced liver injury (flucloxacillin); CRC cis rs6500395 1.000 rs2129243 chr16:48646852 A/T cg04672837 chr16:48644449 N4BP1 0.42 6.09 0.32 3.1e-9 Response to tocilizumab in rheumatoid arthritis; CRC trans rs7580658 0.614 rs7585198 chr2:127962635 C/T cg17010769 chr15:79165973 MORF4L1 -0.42 -6.11 -0.32 2.88e-9 Protein C levels; CRC cis rs909002 0.800 rs4949454 chr1:32099041 A/G cg01639898 chr1:32083012 HCRTR1 -0.32 -6.63 -0.34 1.38e-10 Intelligence (multi-trait analysis); CRC cis rs11711311 1.000 rs7622403 chr3:113472434 A/G cg06805542 chr3:113465803 ATP6V1A;NAA50 0.49 6.67 0.35 1.07e-10 IgG glycosylation; CRC cis rs13191362 1.000 rs66529337 chr6:163005662 G/A cg23758597 chr6:163146217 PARK2 -0.51 -5.91 -0.31 8.33e-9 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs9640161 0.830 rs6722 chr7:150068933 T/C cg13722127 chr7:150037890 RARRES2 0.37 6.02 0.31 4.75e-9 Blood protein levels;Circulating chemerin levels; CRC cis rs4713118 0.955 rs9368529 chr6:27684631 G/A cg20933634 chr6:27740509 NA 0.57 8.15 0.41 7.8e-15 Parkinson's disease; CRC cis rs8141529 0.732 rs2239815 chr22:29192670 C/T cg15103426 chr22:29168792 CCDC117 -0.59 -8.65 -0.43 2.36e-16 Lymphocyte counts; CRC cis rs7394190 0.748 rs2306327 chr10:75573778 A/T cg07699608 chr10:75541558 CHCHD1 0.58 5.82 0.31 1.41e-8 Incident atrial fibrillation; CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg19969113 chr12:118810441 TAOK3 0.41 6.47 0.34 3.61e-10 Obesity-related traits; CRC cis rs7474896 0.537 rs1208683 chr10:38093723 A/G cg25427524 chr10:38739819 LOC399744 0.58 7.16 0.37 5.24e-12 Obesity (extreme); CRC cis rs6456156 0.774 rs968333 chr6:167526198 A/T cg05540913 chr6:167530185 CCR6 0.36 6.48 0.34 3.34e-10 Primary biliary cholangitis; CRC cis rs875971 0.522 rs4502988 chr7:65297746 A/G cg02869306 chr7:64672164 INTS4L1 -0.35 -5.78 -0.3 1.72e-8 Aortic root size; CRC cis rs10504229 0.683 rs56058640 chr8:58128862 C/T cg24829409 chr8:58192753 C8orf71 -0.55 -8.03 -0.4 1.71e-14 Developmental language disorder (linguistic errors); CRC cis rs4975709 0.569 rs4975743 chr5:1859941 G/T cg12288994 chr5:1860383 NA 0.38 6.58 0.34 1.85e-10 Cardiovascular disease risk factors; CRC cis rs2882667 0.931 rs10044736 chr5:138320809 A/G cg09476006 chr5:138032270 NA -0.39 -6.24 -0.33 1.32e-9 Age-related hearing impairment (SNP x SNP interaction); CRC trans rs1814175 0.817 rs7947286 chr11:49874657 C/T cg11707556 chr5:10655725 ANKRD33B -0.44 -8.39 -0.42 1.42e-15 Height; CRC cis rs10946940 0.632 rs9366698 chr6:27672035 C/G cg15845792 chr6:28175446 NA 0.57 7.02 0.36 1.27e-11 Systemic lupus erythematosus; CRC trans rs9929218 1.000 rs9928847 chr16:68797893 C/T cg04657470 chr2:198365150 HSPE1;HSPD1 -0.83 -11.82 -0.55 4e-27 Colorectal cancer; CRC cis rs7833986 0.501 rs17815934 chr8:57038395 G/A cg23139584 chr8:56987506 RPS20;SNORD54 0.92 11.98 0.55 1.1e-27 Height; CRC cis rs9287719 0.614 rs6711473 chr2:10723374 T/C cg00105475 chr2:10696890 NA 0.44 7.0 0.36 1.43e-11 Prostate cancer; CRC cis rs13631 0.697 rs1018330 chr9:139980385 A/C cg11611856 chr9:139973337 UAP1L1 0.52 8.33 0.42 2.25e-15 Cerebrospinal fluid biomarker levels; CRC cis rs7487075 0.893 rs4768115 chr12:46732519 G/C cg22049899 chr12:47219821 SLC38A4 0.33 6.45 0.34 4e-10 Itch intensity from mosquito bite; CRC cis rs1552244 0.938 rs7647987 chr3:10140696 A/G cg02579736 chr3:10068473 FANCD2;CIDECP 0.92 12.66 0.57 3.43e-30 Alzheimer's disease; CRC cis rs12188164 1.000 rs55842567 chr5:437586 G/A cg17553881 chr5:443987 EXOC3;C5orf55 -0.36 -7.56 -0.38 4.07e-13 Cystic fibrosis severity; CRC cis rs9303401 0.659 rs62083362 chr17:56846464 A/G cg02118635 chr17:56770003 RAD51C;TEX14 0.78 9.87 0.48 2.6e-20 Cognitive test performance; CRC cis rs13118159 0.550 rs2336081 chr4:1350322 A/G cg05025164 chr4:1340916 KIAA1530 -0.59 -8.5 -0.42 6.56e-16 Longevity; CRC cis rs11792861 0.781 rs11789252 chr9:111762010 A/T cg05043794 chr9:111880884 C9orf5 -0.33 -5.75 -0.3 2.01e-8 Menarche (age at onset); CRC cis rs4722166 0.630 rs4722169 chr7:22785419 C/T cg05472934 chr7:22766657 IL6 0.77 12.55 0.57 8.65e-30 Lung cancer; CRC cis rs898097 0.756 rs11655103 chr17:80813467 T/C cg03160526 chr17:80928410 B3GNTL1 -0.42 -6.28 -0.33 1.07e-9 Breast cancer; CRC cis rs1129187 0.686 rs6458313 chr6:42922018 A/G cg02359409 chr6:42947317 PEX6 -0.65 -10.31 -0.49 8.81e-22 Alzheimer's disease in APOE e4+ carriers; CRC cis rs6460942 1.000 rs6948314 chr7:12418363 T/A cg20607287 chr7:12443886 VWDE -0.62 -7.11 -0.36 7.47e-12 Coronary artery disease; CRC cis rs4664308 0.870 rs2305818 chr2:161029218 G/A cg03641300 chr2:160917029 PLA2R1 -0.72 -12.09 -0.55 4.33e-28 Idiopathic membranous nephropathy; CRC cis rs6866344 0.561 rs55974982 chr5:178141421 G/A cg10224037 chr5:178157518 ZNF354A 0.76 11.17 0.52 9.07e-25 Neutrophil percentage of white cells; CRC cis rs10504229 0.636 rs10958525 chr8:58051528 C/A cg22535103 chr8:58192502 C8orf71 -0.56 -6.71 -0.35 8.37e-11 Developmental language disorder (linguistic errors); CRC cis rs11785400 0.762 rs9694556 chr8:143727841 A/G cg10596483 chr8:143751796 JRK 0.47 6.35 0.33 7.33e-10 Schizophrenia; CRC trans rs916888 0.779 rs430685 chr17:44859148 T/C cg22968622 chr17:43663579 NA -1.2 -15.72 -0.65 6.5e-42 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg25441200 chr7:156742235 NOM1 0.42 6.23 0.32 1.4e-9 Intelligence (multi-trait analysis); CRC cis rs4332037 0.722 rs4719331 chr7:1914679 A/C cg23422044 chr7:1970798 MAD1L1 -0.6 -7.92 -0.4 3.64e-14 Bipolar disorder; CRC cis rs9549260 0.785 rs6563842 chr13:41244297 G/T cg21288729 chr13:41239152 FOXO1 0.5 7.76 0.39 1.08e-13 Red blood cell count; CRC cis rs35995292 0.534 rs2392607 chr7:38930380 G/A cg19327137 chr7:38886074 VPS41 0.65 10.86 0.51 1.13e-23 Subjective well-being (multi-trait analysis); CRC cis rs2073300 0.609 rs6137948 chr20:23416845 G/A cg12062639 chr20:23401060 NAPB 0.84 7.66 0.39 2.1e-13 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs9322193 0.961 rs4870144 chr6:149896676 C/G cg05861140 chr6:150128134 PCMT1 -0.37 -5.9 -0.31 8.86e-9 Lung cancer; CRC cis rs7762018 0.891 rs4716343 chr6:170143817 C/G cg17545662 chr6:170176663 C6orf70 0.57 6.4 0.33 5.21e-10 Thiazide-induced adverse metabolic effects in hypertensive patients; CRC cis rs4555082 0.834 rs2735816 chr14:105721603 C/G cg10792982 chr14:105748885 BRF1 -0.41 -7.15 -0.37 5.63e-12 Mean platelet volume;Platelet distribution width; CRC cis rs2228479 0.717 rs2270460 chr16:89972416 C/A cg19635926 chr16:89946313 TCF25 0.52 5.62 0.3 4.09e-8 Skin colour saturation; CRC trans rs11343 0.675 rs7359333 chr16:19262344 A/T cg19982557 chr2:132250307 FAM128A;LOC150776 -0.49 -6.22 -0.32 1.52e-9 Parkinson's disease; CRC cis rs9868809 1.000 rs9868809 chr3:48681053 C/T cg00383909 chr3:49044727 WDR6 0.78 7.53 0.38 4.82e-13 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; CRC trans rs4927850 0.918 rs4361313 chr3:195752260 A/G cg16724585 chr3:197361211 NA -0.49 -7.19 -0.37 4.47e-12 Pancreatic cancer; CRC cis rs4664304 0.802 rs62175470 chr2:160858255 G/C cg03641300 chr2:160917029 PLA2R1 -0.44 -6.27 -0.33 1.16e-9 Crohn's disease;Inflammatory bowel disease; CRC cis rs6688613 0.685 rs10800276 chr1:166858941 A/G ch.1.3259774R chr1:166827647 TADA1 -0.5 -5.62 -0.3 4.17e-8 Refractive astigmatism; CRC cis rs9322817 0.691 rs9404586 chr6:105332814 A/G cg02098413 chr6:105308735 HACE1 0.46 9.2 0.45 4.09e-18 Thyroid stimulating hormone; CRC cis rs11190604 1.000 rs12219158 chr10:102302923 T/C cg07080220 chr10:102295463 HIF1AN 0.47 5.68 0.3 2.96e-8 Palmitoleic acid (16:1n-7) levels; CRC cis rs6831352 0.918 rs17218162 chr4:100056060 G/A cg13256891 chr4:100009986 ADH5 -0.66 -8.88 -0.44 4.37e-17 Alcohol dependence; CRC cis rs9487051 0.714 rs9386797 chr6:109632520 C/A cg21918786 chr6:109611834 NA -0.39 -6.85 -0.35 3.7e-11 Reticulocyte fraction of red cells; CRC cis rs282587 0.569 rs7986147 chr13:113398784 A/C cg04656015 chr13:113407548 ATP11A 0.64 7.99 0.4 2.28e-14 Glycated hemoglobin levels; CRC cis rs344364 0.511 rs2917519 chr16:1950479 C/A cg09830162 chr16:1889614 FAHD1;C16orf73 -0.77 -9.32 -0.46 1.72e-18 Glomerular filtration rate in chronic kidney disease; CRC cis rs4713118 0.513 rs149959 chr6:28013854 T/C cg20615401 chr6:28092323 ZSCAN16 0.46 6.19 0.32 1.83e-9 Parkinson's disease; CRC trans rs10504229 1.000 rs57941207 chr8:58169821 A/G cg04077850 chr5:125800366 GRAMD3 0.37 6.18 0.32 1.91e-9 Developmental language disorder (linguistic errors); CRC cis rs7224737 1.000 rs9915255 chr17:40284191 C/T cg02450064 chr17:40260053 DHX58 -0.43 -6.19 -0.32 1.74e-9 Fibrinogen levels; CRC cis rs9788721 0.836 rs17483929 chr15:78742376 C/T cg18825076 chr15:78729989 IREB2 -0.45 -6.68 -0.35 1.04e-10 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio;Emphysema imaging phenotypes;Emphysema distribution in smoking;Local histogram emphysema pattern;Post bronchodilator FEV1/FVC ratio in COPD; CRC cis rs11971779 0.553 rs11973507 chr7:139099461 A/T cg23387468 chr7:139079360 LUC7L2 0.41 7.05 0.36 1.04e-11 Diisocyanate-induced asthma; CRC cis rs728616 0.867 rs61859763 chr10:81671615 A/T cg05935833 chr10:81318306 SFTPA2 -0.7 -7.71 -0.39 1.53e-13 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs6674176 0.628 rs12145999 chr1:44428632 C/T cg12908607 chr1:44402522 ARTN -0.59 -10.62 -0.51 7.39e-23 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Cognitive ability; CRC cis rs713587 0.624 rs1550110 chr2:25124563 T/C cg04586622 chr2:25135609 ADCY3 -0.55 -10.22 -0.49 1.81e-21 Body mass index in non-asthmatics; CRC cis rs9916302 0.904 rs11078910 chr17:37671269 G/T cg03013999 chr17:37608204 MED1 0.45 6.9 0.36 2.72e-11 Glomerular filtration rate (creatinine); CRC cis rs6976053 0.935 rs6954151 chr7:100484917 C/T cg10426581 chr7:100472382 SRRT 0.38 5.78 0.3 1.74e-8 Plasminogen activator inhibitor type 1 levels (PAI-1); CRC cis rs11122272 0.735 rs2066140 chr1:231504311 C/G cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.55 -8.28 -0.42 3.08e-15 Hemoglobin concentration; CRC cis rs478304 0.651 rs4014195 chr11:65506822 C/G cg05805236 chr11:65401703 PCNXL3 0.36 5.74 0.3 2.18e-8 Acne (severe); CRC cis rs904251 0.522 rs882322 chr6:37484103 A/G cg25019722 chr6:37503610 NA -0.47 -8.79 -0.44 8.44e-17 Cognitive performance; CRC cis rs1150668 0.796 rs728122 chr6:28399124 G/A cg15845792 chr6:28175446 NA 0.46 6.67 0.35 1.06e-10 Pubertal anthropometrics; CRC cis rs4073416 0.518 rs7157109 chr14:65900433 C/G cg03016385 chr14:66212404 NA -0.41 -5.67 -0.3 3.13e-8 N-glycan levels; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg04674497 chr6:45346044 SUPT3H;RUNX2 0.5 7.23 0.37 3.41e-12 Response to antipsychotic treatment; CRC cis rs2730245 0.851 rs2657333 chr7:158728743 G/A cg24397884 chr7:158709396 WDR60 -0.93 -16.16 -0.67 1.14e-43 Height; CRC trans rs7615952 0.866 rs1976459 chr3:125647486 A/T cg00769240 chr8:12517080 NA -0.57 -7.05 -0.36 1.04e-11 Blood pressure (smoking interaction); CRC cis rs55871839 0.684 rs7002967 chr8:59816806 T/A cg07426533 chr8:59803705 TOX -0.34 -5.87 -0.31 1.06e-8 Pneumonia; CRC cis rs4737010 0.501 rs10099197 chr8:41654458 C/T cg17182837 chr8:41585554 ANK1 -0.49 -6.34 -0.33 7.47e-10 Lymphocyte counts;High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Reticulocyte count;Reticulocyte fraction of red cells;Mean corpuscular volume;Immature fraction of reticulocytes;Mean corpuscular hemoglobin concentration; CRC trans rs2832077 0.883 rs11702413 chr21:30188395 A/C cg14791747 chr16:20752902 THUMPD1 0.53 6.38 0.33 6e-10 Cognitive test performance; CRC cis rs4132509 1.000 rs10927050 chr1:243805907 A/G cg21452805 chr1:244014465 NA 0.46 6.17 0.32 2.04e-9 RR interval (heart rate); CRC cis rs7412746 0.658 rs2230061 chr1:150727539 G/A cg15448220 chr1:150897856 SETDB1 0.55 7.7 0.39 1.64e-13 Melanoma; CRC cis rs8072100 0.790 rs11079783 chr17:45686016 C/T cg25173405 chr17:45401733 C17orf57 0.39 5.77 0.3 1.86e-8 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs9311474 0.597 rs13303 chr3:52558008 T/C cg11645453 chr3:52864694 ITIH4 0.35 6.39 0.33 5.66e-10 Electroencephalogram traits; CRC cis rs2811415 0.597 rs12695504 chr3:127791388 C/G cg13719885 chr3:127795394 NA -0.38 -5.91 -0.31 8.78e-9 Lung function (FEV1/FVC); CRC cis rs2932538 0.922 rs3790612 chr1:113084146 G/A cg22162597 chr1:113214053 CAPZA1 0.71 9.95 0.48 1.51e-20 Systolic blood pressure;Diastolic blood pressure;Hypertension;Blood pressure; CRC cis rs4363385 0.747 rs1015995 chr1:152976114 G/C cg25856811 chr1:152973957 SPRR3 -0.25 -6.76 -0.35 6.27e-11 Inflammatory skin disease; CRC cis rs7843479 0.965 rs17581910 chr8:21799626 A/G cg17168535 chr8:21777572 XPO7 0.59 9.58 0.47 2.5e-19 Mean corpuscular volume; CRC cis rs2836974 0.666 rs2836975 chr21:40663620 A/G cg06238570 chr21:40685208 BRWD1 -0.8 -12.93 -0.58 3.44e-31 Cognitive function; CRC cis rs4713118 0.527 rs4713151 chr6:28136356 G/A cg25164649 chr6:28176230 NA 0.78 9.66 0.47 1.33e-19 Parkinson's disease; CRC cis rs6570726 0.791 rs4896820 chr6:145894957 T/C cg23711669 chr6:146136114 FBXO30 0.68 11.39 0.53 1.44e-25 Lobe attachment (rater-scored or self-reported); CRC cis rs13191362 0.935 rs73023493 chr6:162952769 G/A cg06582575 chr6:163149167 PACRG;PARK2 0.79 9.67 0.47 1.25e-19 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs2549003 1.000 rs2549009 chr5:131826765 T/C cg00255919 chr5:131827918 IRF1 -0.59 -11.57 -0.54 3.41e-26 Asthma (sex interaction); CRC cis rs174551 1 rs174551 chr11:61573684 T/C cg00603274 chr11:61596626 FADS2 -0.44 -6.4 -0.33 5.33e-10 LDL cholesterol; CRC cis rs9296092 0.521 rs56332659 chr6:33537887 T/C cg13560919 chr6:33536144 NA -0.42 -5.69 -0.3 2.84e-8 Age at smoking initiation in chronic obstructive pulmonary disease; CRC cis rs12586317 0.511 rs113770696 chr14:35444383 C/T cg05294307 chr14:35346193 BAZ1A -0.71 -7.72 -0.39 1.41e-13 Psoriasis; CRC cis rs875971 0.545 rs17138156 chr7:65714695 C/T cg18876405 chr7:65276391 NA 0.45 6.23 0.32 1.44e-9 Aortic root size; CRC cis rs4665809 0.590 rs35746418 chr2:26455002 C/G cg27170947 chr2:26402098 FAM59B 0.59 7.71 0.39 1.53e-13 Gut microbiome composition (summer); CRC cis rs875971 1.000 rs778726 chr7:65828731 C/T cg18876405 chr7:65276391 NA 0.52 9.03 0.45 1.5e-17 Aortic root size; CRC cis rs2289583 0.500 rs67168917 chr15:75391494 G/T cg14664628 chr15:75095509 CSK 0.4 5.78 0.3 1.71e-8 Systemic lupus erythematosus; CRC cis rs7412746 0.658 rs10305711 chr1:150802996 T/C cg18016565 chr1:150552671 MCL1 0.44 6.23 0.32 1.42e-9 Melanoma; CRC cis rs853679 0.517 rs11552219 chr6:28126834 C/T cg12172441 chr6:28176163 NA 0.64 7.53 0.38 5.03e-13 Depression; CRC cis rs1532331 0.898 rs10076858 chr5:43134752 G/A cg09164108 chr5:43007320 NA 0.39 5.93 0.31 7.84e-9 Menarche (age at onset); CRC cis rs6860806 0.661 rs4705929 chr5:131584178 G/T cg09877947 chr5:131593287 PDLIM4 0.45 8.41 0.42 1.27e-15 Breast cancer; CRC cis rs3806843 0.735 rs2530235 chr5:140072647 G/T cg19875535 chr5:140030758 IK -0.62 -10.03 -0.48 7.62e-21 Depressive symptoms (multi-trait analysis); CRC trans rs2303319 0.504 rs72877343 chr2:162607487 A/C cg11326919 chr17:43324904 LOC100133991 -0.64 -5.97 -0.31 5.99e-9 Cognitive function; CRC cis rs9399135 0.967 rs9376077 chr6:135299713 C/G cg24558204 chr6:135376177 HBS1L 0.5 7.88 0.4 4.98e-14 Red blood cell count; CRC trans rs4650994 0.544 rs4132058 chr1:178505557 A/C cg05059571 chr16:84539110 KIAA1609 -0.6 -8.19 -0.41 5.95e-15 HDL cholesterol levels;HDL cholesterol; CRC cis rs7216064 1.000 rs58122682 chr17:65876915 T/C cg12091567 chr17:66097778 LOC651250 -0.67 -7.74 -0.39 1.24e-13 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CRC cis rs10504229 0.774 rs72650880 chr8:58164727 C/T cg05313129 chr8:58192883 C8orf71 -0.49 -5.94 -0.31 7.15e-9 Developmental language disorder (linguistic errors); CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg03990565 chr11:64885225 ZNHIT2 0.48 6.7 0.35 9.12e-11 Anxiety disorder; CRC cis rs9902453 0.904 rs6505148 chr17:28289818 C/T cg26525008 chr17:28256777 EFCAB5;SSH2 0.69 11.24 0.53 5.13e-25 Coffee consumption (cups per day); CRC cis rs9914988 0.830 rs7221773 chr17:27202888 C/T cg20469991 chr17:27169893 C17orf63 -0.62 -5.84 -0.31 1.22e-8 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs2842992 0.830 rs2025189 chr6:160137518 C/T cg11366901 chr6:160182831 ACAT2 0.94 13.05 0.58 1.21e-31 Age-related macular degeneration (geographic atrophy); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg26726589 chr20:306364 SOX12 0.38 6.23 0.32 1.42e-9 Liver disease severity in Alagille syndrome; CRC cis rs2243480 1.000 rs313832 chr7:65550891 G/T cg12463550 chr7:65579703 CRCP 0.67 6.4 0.33 5.2e-10 Diabetic kidney disease; CRC cis rs9287719 0.967 rs4669598 chr2:10757838 T/C cg00105475 chr2:10696890 NA 0.44 7.14 0.37 6.13e-12 Prostate cancer; CRC cis rs7259376 0.936 rs59598661 chr19:22537029 T/A cg02657401 chr19:22469223 NA -0.33 -7.46 -0.38 7.96e-13 Menopause (age at onset); CRC cis rs9814567 0.964 rs9815894 chr3:134282796 C/G cg06109529 chr3:134205091 CEP63;ANAPC13 -0.82 -12.36 -0.56 4.3e-29 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs908922 0.676 rs12132469 chr1:152491856 G/T cg23254163 chr1:152506842 NA 0.5 10.14 0.49 3.42e-21 Hair morphology; CRC cis rs1949733 1.000 rs1916326 chr4:8500023 G/A cg11789530 chr4:8429930 ACOX3 -0.83 -12.24 -0.56 1.26e-28 Response to antineoplastic agents; CRC cis rs2070488 0.775 rs4407366 chr3:38521425 C/T cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.68 11.37 0.53 1.72e-25 Electrocardiographic conduction measures; CRC cis rs10504229 0.728 rs72650868 chr8:58155568 G/C cg02290350 chr8:58132656 NA -0.51 -6.57 -0.34 1.98e-10 Developmental language disorder (linguistic errors); CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg08265551 chr1:151032119 CDC42SE1;MLLT11 0.35 6.07 0.32 3.57e-9 Obesity-related traits; CRC cis rs7666738 0.830 rs3857217 chr4:99034347 T/C cg17366294 chr4:99064904 C4orf37 0.44 7.47 0.38 7.18e-13 Colonoscopy-negative controls vs population controls; CRC cis rs9818758 0.607 rs67831908 chr3:49313513 T/G cg07636037 chr3:49044803 WDR6 -0.72 -6.08 -0.32 3.38e-9 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; CRC cis rs6496667 0.865 rs75714371 chr15:90880602 G/A cg04176472 chr15:90893244 GABARAPL3 0.58 6.61 0.34 1.58e-10 Rheumatoid arthritis; CRC cis rs6838801 0.554 rs344122 chr4:77637502 G/T cg17476223 chr4:77663285 SHROOM3 0.46 6.1 0.32 3.02e-9 Cleft lip with or without cleft palate; CRC cis rs7923609 0.812 rs10761753 chr10:65161903 G/A cg08743896 chr10:65200160 JMJD1C -0.43 -6.19 -0.32 1.82e-9 Educational attainment;Liver enzyme levels (alkaline phosphatase); CRC cis rs425277 0.606 rs2459984 chr1:2086312 A/G cg03732007 chr1:2071316 PRKCZ 0.4 6.47 0.34 3.64e-10 Height; CRC cis rs514406 0.861 rs7526275 chr1:53245849 C/T cg27535305 chr1:53392650 SCP2 0.39 7.07 0.36 9.43e-12 Monocyte count; CRC cis rs881375 0.967 rs2270231 chr9:123650982 C/G cg09419670 chr9:123605666 PSMD5;LOC253039 0.59 8.63 0.43 2.61e-16 Rheumatoid arthritis; CRC trans rs10982213 0.830 rs2274163 chr9:117188714 C/T cg09081385 chr12:120972070 RNF10 -0.43 -6.52 -0.34 2.7e-10 Interleukin-6 levels; CRC cis rs875971 0.798 rs6460304 chr7:65964728 G/A cg12463550 chr7:65579703 CRCP 0.49 6.84 0.35 3.89e-11 Aortic root size; CRC cis rs908922 0.676 rs11205014 chr1:152483634 C/T cg09873164 chr1:152488093 CRCT1 0.37 6.2 0.32 1.73e-9 Hair morphology; CRC trans rs1005277 0.579 rs9418322 chr10:38377296 G/T cg17830980 chr10:43048298 ZNF37B -0.58 -9.66 -0.47 1.35e-19 Extrinsic epigenetic age acceleration; CRC cis rs875971 0.767 rs12668005 chr7:65909021 T/C cg18876405 chr7:65276391 NA 0.52 8.27 0.41 3.31e-15 Aortic root size; CRC cis rs9393692 0.557 rs9379846 chr6:26314238 G/C cg00631329 chr6:26305371 NA -0.52 -8.72 -0.43 1.42e-16 Educational attainment; CRC cis rs2645694 0.533 rs2645680 chr4:77820956 T/C cg03477792 chr4:77819574 ANKRD56 0.42 6.1 0.32 3.02e-9 Emphysema distribution in smoking; CRC cis rs6504950 0.720 rs28564882 chr17:52989598 C/T cg26251398 chr17:52985966 TOM1L1 0.42 6.16 0.32 2.14e-9 Breast cancer; CRC cis rs17345786 0.511 rs13061565 chr3:101392270 T/C cg12386194 chr3:101231763 SENP7 0.49 7.11 0.36 7.34e-12 Colonoscopy-negative controls vs population controls; CRC trans rs7395662 1.000 rs10838966 chr11:48589723 C/G cg21153622 chr11:89784906 NA -0.46 -7.35 -0.38 1.54e-12 HDL cholesterol; CRC cis rs9325144 0.505 rs901635 chr12:38646572 A/C cg26384229 chr12:38710491 ALG10B -0.57 -8.35 -0.42 1.87e-15 Morning vs. evening chronotype; CRC cis rs875971 0.862 rs7798630 chr7:65771479 G/C cg11764359 chr7:65958608 NA -0.59 -8.77 -0.44 1e-16 Aortic root size; CRC cis rs7020830 0.505 rs12553878 chr9:37095705 C/T cg14294708 chr9:37120828 ZCCHC7 0.78 13.71 0.6 3.83e-34 Schizophrenia; CRC cis rs131805 0.794 rs131813 chr22:50961169 A/G cg05418105 chr22:50981406 NA -0.59 -7.32 -0.37 1.92e-12 Granulocyte percentage of myeloid white cells; CRC cis rs9902453 0.845 rs12601963 chr17:28246358 A/G cg26525008 chr17:28256777 EFCAB5;SSH2 0.57 8.56 0.43 4.53e-16 Coffee consumption (cups per day); CRC cis rs847577 0.630 rs3801294 chr7:97822210 G/A cg21770322 chr7:97807741 LMTK2 0.86 19.38 0.73 2.28e-56 Breast cancer; CRC cis rs1003719 0.680 rs2835620 chr21:38505581 C/T cg10648535 chr21:38446584 PIGP;TTC3 -0.48 -6.7 -0.35 8.99e-11 Eye color traits; CRC cis rs6723226 0.772 rs2366894 chr2:32713706 A/T cg02381751 chr2:32503542 YIPF4 0.54 7.81 0.4 7.5e-14 Intelligence (multi-trait analysis); CRC cis rs763121 0.819 rs8137829 chr22:39061030 G/A cg06544989 chr22:39130855 UNC84B 0.45 6.86 0.35 3.33e-11 Menopause (age at onset); CRC trans rs11146838 1 rs11146838 chr10:39149977 A/T cg27523141 chr10:43048294 ZNF37B 0.42 6.01 0.31 4.99e-9 Breast cancer; CRC cis rs748404 0.631 rs11070399 chr15:43646347 A/G cg02155558 chr15:43621948 ADAL;LCMT2 0.54 7.85 0.4 5.94e-14 Lung cancer; CRC cis rs11677416 1.000 rs6542093 chr2:113528536 G/A cg06156847 chr2:113672199 IL1F7 -0.39 -5.96 -0.31 6.34e-9 Response to antipsychotic treatment in schizophrenia (working memory); CRC cis rs4713118 0.869 rs9366700 chr6:27696951 C/T cg02683197 chr6:28174875 NA 0.63 8.62 0.43 2.81e-16 Parkinson's disease; CRC trans rs2303319 0.504 rs62189053 chr2:162624324 G/A cg12500891 chr11:57225987 NA -0.65 -6.05 -0.32 3.87e-9 Cognitive function; CRC trans rs11098499 0.863 rs3822194 chr4:120471648 A/G cg25214090 chr10:38739885 LOC399744 0.65 10.45 0.5 2.9e-22 Corneal astigmatism; CRC cis rs6860806 0.507 rs582490 chr5:131710095 G/A cg18301423 chr5:131593218 PDLIM4 -0.38 -6.41 -0.33 5.02e-10 Breast cancer; CRC cis rs12745968 0.594 rs10735781 chr1:93121107 C/G cg17283838 chr1:93427260 FAM69A -0.46 -6.34 -0.33 7.46e-10 Bipolar disorder and schizophrenia; CRC cis rs2739330 0.796 rs2154594 chr22:24254055 A/G cg23131131 chr22:24373011 LOC391322 0.64 9.89 0.48 2.38e-20 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs1862618 0.853 rs2548664 chr5:56133555 G/A cg12311346 chr5:56204834 C5orf35 -0.78 -10.28 -0.49 1.11e-21 Initial pursuit acceleration; CRC cis rs10504229 0.953 rs57669205 chr8:58172253 T/C cg02725872 chr8:58115012 NA -0.39 -6.55 -0.34 2.22e-10 Developmental language disorder (linguistic errors); CRC cis rs35110281 0.712 rs8133523 chr21:45062403 A/G cg04455712 chr21:45112962 RRP1B 0.41 8.12 0.41 9.76e-15 Mean corpuscular volume; CRC cis rs2014572 0.967 rs10426174 chr19:57756055 G/A cg24459738 chr19:57751996 ZNF805 -0.53 -8.19 -0.41 5.93e-15 Hyperactive-impulsive symptoms; CRC cis rs4665809 1.000 rs11126364 chr2:26314515 A/G cg26119090 chr2:26468346 HADHA;HADHB -0.61 -7.91 -0.4 3.92e-14 Gut microbiome composition (summer); CRC cis rs6951245 1.000 rs74366004 chr7:1088630 A/C cg22907277 chr7:1156413 C7orf50 0.71 7.23 0.37 3.34e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC trans rs16846053 0.786 rs72877309 chr2:162587828 A/G cg25193742 chr10:104614220 C10orf32 -0.78 -6.44 -0.33 4.19e-10 Blood osmolality (transformed sodium); CRC cis rs10504229 0.953 rs78089850 chr8:58171557 A/G cg24829409 chr8:58192753 C8orf71 -0.67 -10.85 -0.51 1.2e-23 Developmental language disorder (linguistic errors); CRC cis rs9322817 0.691 rs4504502 chr6:105325332 A/G cg02098413 chr6:105308735 HACE1 0.43 8.49 0.42 7.27e-16 Thyroid stimulating hormone; CRC cis rs910316 0.875 rs12588099 chr14:75594462 A/T cg03030879 chr14:75389066 RPS6KL1 -0.48 -7.37 -0.38 1.39e-12 Height; CRC cis rs4689388 0.926 rs4308429 chr4:6294001 A/G cg00701064 chr4:6280414 WFS1 0.75 13.24 0.59 2.22e-32 Type 2 diabetes and other traits;Type 2 diabetes; CRC cis rs9467711 0.591 rs60512607 chr6:26054171 T/A cg19084075 chr6:26124329 HIST1H2AC;HIST1H2BC 0.64 6.0 0.31 5.12e-9 Autism spectrum disorder or schizophrenia; CRC cis rs875971 0.545 rs3735147 chr7:65970528 A/C cg03233332 chr7:66118400 NA -0.42 -5.86 -0.31 1.12e-8 Aortic root size; CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg00177013 chr20:62339100 ARFRP1;ZGPAT -0.54 -6.65 -0.34 1.24e-10 Diisocyanate-induced asthma; CRC trans rs4843747 0.605 rs4072779 chr16:88107290 C/T cg26811252 chr16:29126840 RRN3P2 0.61 8.31 0.42 2.62e-15 Menopause (age at onset); CRC cis rs2213920 0.679 rs4979533 chr9:118210764 C/T cg13918206 chr9:118159781 DEC1 0.59 5.8 0.3 1.58e-8 Docetaxel-induced peripheral neuropathy in metastatic castrate-resistant prostate cancer; CRC cis rs6694672 1.000 rs12092294 chr1:196966853 C/T cg13682187 chr1:196946512 CFHR5 0.46 7.37 0.38 1.39e-12 Asthma; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg01926595 chr17:4851808 PFN1 0.38 6.89 0.36 2.82e-11 Liver disease severity in Alagille syndrome; CRC cis rs782590 0.967 rs62165173 chr2:55741666 T/C cg18811423 chr2:55921094 PNPT1 0.84 15.48 0.65 5.72e-41 Metabolic syndrome; CRC cis rs35306767 0.855 rs35666723 chr10:867346 A/G cg26597838 chr10:835615 NA 1.25 15.13 0.64 1.26e-39 Eosinophil percentage of granulocytes; CRC cis rs9467711 0.606 rs9358935 chr6:26369587 A/G cg16898833 chr6:26189333 HIST1H4D 0.76 6.58 0.34 1.88e-10 Autism spectrum disorder or schizophrenia; CRC cis rs7772486 0.790 rs9497427 chr6:146238302 T/A cg23711669 chr6:146136114 FBXO30 -0.66 -11.27 -0.53 3.91e-25 Lobe attachment (rater-scored or self-reported); CRC cis rs728616 0.867 rs12411407 chr10:81828231 C/T cg05935833 chr10:81318306 SFTPA2 -0.55 -6.42 -0.33 4.66e-10 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs875971 1.000 rs778694 chr7:65871558 A/G cg18912574 chr7:65842487 NCRNA00174 0.36 6.18 0.32 1.88e-9 Aortic root size; CRC cis rs2732480 0.577 rs2450994 chr12:48721832 G/A cg24011408 chr12:48396354 COL2A1 0.45 6.19 0.32 1.84e-9 Hemoglobin concentration;Red blood cell count;Hematocrit; CRC cis rs7809950 0.678 rs62483641 chr7:106901741 T/C cg23024343 chr7:107201750 COG5 -0.74 -10.23 -0.49 1.63e-21 Coronary artery disease; CRC cis rs9584850 0.520 rs10508036 chr13:99157398 C/G cg07423050 chr13:99094983 FARP1 -0.47 -5.9 -0.31 9.11e-9 Neuroticism; CRC cis rs9747201 1.000 rs55638685 chr17:80107566 G/C cg09264619 chr17:80180166 NA 0.51 7.3 0.37 2.17e-12 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs769267 0.965 rs2074303 chr19:19381755 C/T cg02546618 chr19:19431379 KIAA0892;SF4 0.46 6.3 0.33 9.51e-10 Tonsillectomy; CRC cis rs801193 1.000 rs2003301 chr7:66147656 G/C cg18876405 chr7:65276391 NA -0.61 -10.75 -0.51 2.74e-23 Aortic root size; CRC cis rs9292777 0.897 rs6451494 chr5:40411291 T/C cg09067459 chr5:40385259 NA 0.51 8.86 0.44 5.15e-17 Crohn's disease;Multiple sclerosis; CRC cis rs736408 0.812 rs2071508 chr3:52826846 A/G cg18404041 chr3:52824283 ITIH1 0.52 10.37 0.5 5.51e-22 Bipolar disorder; CRC cis rs6089584 0.888 rs6089624 chr20:60619907 C/G cg23262073 chr20:60523788 NA -0.46 -7.16 -0.37 5.39e-12 Body mass index; CRC cis rs9393777 0.513 rs61240102 chr6:27124904 G/C cg12292205 chr6:26970375 C6orf41 -0.77 -8.39 -0.42 1.45e-15 Intelligence (multi-trait analysis); CRC cis rs71403859 1.000 rs71403859 chr16:71640207 C/T cg08717414 chr16:71523259 ZNF19 -1.14 -10.91 -0.52 7.62e-24 Post bronchodilator FEV1; CRC cis rs6121246 0.908 rs6089094 chr20:30431771 C/T cg13852791 chr20:30311386 BCL2L1 0.58 9.39 0.46 9.98e-19 Mean corpuscular hemoglobin; CRC cis rs1153858 1.000 rs1346268 chr15:45673029 T/C cg14582100 chr15:45693742 SPATA5L1 0.28 5.72 0.3 2.41e-8 Homoarginine levels; CRC trans rs561341 0.739 rs9906455 chr17:30215669 G/A cg20587970 chr11:113659929 NA 0.63 8.22 0.41 4.83e-15 Hip circumference adjusted for BMI; CRC cis rs17345786 0.511 rs12639028 chr3:101346033 G/C cg12386194 chr3:101231763 SENP7 0.49 6.84 0.35 3.77e-11 Colonoscopy-negative controls vs population controls; CRC cis rs10504229 0.517 rs75486476 chr8:58056079 G/T cg20607798 chr8:58055168 NA 0.46 7.29 0.37 2.33e-12 Developmental language disorder (linguistic errors); CRC trans rs877282 0.853 rs12779017 chr10:763619 T/C cg22713356 chr15:30763199 NA 1.28 15.26 0.64 3.9e-40 Uric acid levels; CRC cis rs812925 0.512 rs7558954 chr2:61384906 T/C cg10580144 chr2:61372316 C2orf74 0.36 8.06 0.41 1.41e-14 Immature fraction of reticulocytes; CRC cis rs7666738 0.830 rs11097598 chr4:98946057 T/C cg05340658 chr4:99064831 C4orf37 0.6 9.38 0.46 1.12e-18 Colonoscopy-negative controls vs population controls; CRC cis rs2415984 0.540 rs1494095 chr14:46960671 T/C cg14871534 chr14:47121158 RPL10L 0.4 5.95 0.31 6.86e-9 Number of children ever born; CRC cis rs780094 0.500 rs74175068 chr2:27833502 T/C cg27432699 chr2:27873401 GPN1 0.49 6.43 0.33 4.42e-10 Calcium levels;Fasting blood insulin;Metabolic traits;Triglyceride levels;Fasting plasma glucose;Urate levels in overweight individuals;Urate levels in obese individuals;Uric acid levels;Height;Age-related diseases, mortality and associated endophenotypes;Renal underexcretion gout;Fasting blood glucose (BMI interaction);Urate levels;Gondoic acid (20:1n-9) levels;Fasting blood insulin (BMI interaction);Triglycerides;Plasma omega-3 polyunsaturated fatty acid levels (docosapentaenoic acid);Type 2 diabetes;Nonalcoholic fatty liver disease;Hypertriglyceridemia;C-reactive protein;Age-related disease endophenotypes;LDL cholesterol;Metabolic syndrome;Crohn's disease;Alcohol consumption (drinks per week);Homeostasis model assessment of insulin resistance;Alcohol consumption;Red blood cell count;Fasting blood glucose; CRC cis rs524281 0.861 rs580891 chr11:65954681 A/C cg14036092 chr11:66035641 RAB1B -0.5 -6.3 -0.33 9.37e-10 Electroencephalogram traits; CRC cis rs7618915 0.508 rs7628578 chr3:52628321 A/T cg18404041 chr3:52824283 ITIH1 -0.42 -8.72 -0.43 1.41e-16 Bipolar disorder; CRC cis rs11711311 0.955 rs34458493 chr3:113396473 C/T cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.51 -6.78 -0.35 5.7e-11 IgG glycosylation; CRC cis rs9388451 0.839 rs11154331 chr6:126111429 A/T cg05901451 chr6:126070800 HEY2 -0.65 -11.4 -0.53 1.35e-25 Brugada syndrome; CRC cis rs1182196 0.502 rs757786 chr7:2836019 C/T cg19717773 chr7:2847554 GNA12 -0.51 -8.97 -0.44 2.23e-17 Plateletcrit; CRC cis rs2797160 1.000 rs78602343 chr6:126019768 T/C cg05901451 chr6:126070800 HEY2 0.4 6.02 0.32 4.63e-9 Endometrial cancer; CRC cis rs734999 0.545 rs10910106 chr1:2538886 G/T cg18854424 chr1:2615690 NA 0.4 7.67 0.39 2e-13 Ulcerative colitis; CRC trans rs7615952 0.546 rs2979338 chr3:125343126 G/T cg16558177 chr4:4109446 NA -0.56 -6.52 -0.34 2.73e-10 Blood pressure (smoking interaction); CRC cis rs6912958 0.500 rs4706287 chr6:87806496 A/G cg12350822 chr6:88032061 C6orf162;GJB7 -0.41 -7.69 -0.39 1.76e-13 Monocyte percentage of white cells; CRC cis rs57994353 0.793 rs12552167 chr9:139322927 C/T cg13611204 chr9:139324423 INPP5E -0.45 -6.32 -0.33 8.33e-10 Eosinophil counts;Cutaneous squamous cell carcinoma; CRC cis rs10504229 0.636 rs77753517 chr8:58115897 C/T cg21724239 chr8:58056113 NA 0.49 6.81 0.35 4.75e-11 Developmental language disorder (linguistic errors); CRC cis rs2249694 0.537 rs9418988 chr10:135327632 C/T cg16964102 chr10:135390573 NA -0.44 -6.85 -0.35 3.59e-11 Obesity-related traits; CRC cis rs9534288 0.659 rs9534314 chr13:46654844 A/G cg15192986 chr13:46630673 CPB2 -0.68 -8.68 -0.43 1.86e-16 Blood protein levels; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg03226425 chr6:170151538 C6orf70;TCTE3 0.46 6.45 0.34 3.94e-10 Response to antipsychotic treatment; CRC cis rs7811142 1.000 rs11559117 chr7:100076614 A/G cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.73 9.87 0.48 2.71e-20 Platelet count; CRC cis rs561341 1.000 rs1681718 chr17:30296445 G/A cg12193833 chr17:30244370 NA -0.74 -8.72 -0.43 1.45e-16 Hip circumference adjusted for BMI; CRC cis rs875971 0.825 rs4587224 chr7:65736182 G/A cg11764359 chr7:65958608 NA -0.6 -9.24 -0.45 3.1e-18 Aortic root size; CRC cis rs6772849 0.930 rs4857912 chr3:128329224 G/A cg08795948 chr3:128337044 NA 0.34 5.82 0.31 1.42e-8 Monocyte percentage of white cells;Monocyte count; CRC cis rs11764590 0.950 rs11514731 chr7:2051503 C/G cg02825527 chr7:2087843 MAD1L1 -0.5 -5.91 -0.31 8.66e-9 Neuroticism; CRC trans rs561341 1.000 rs72823785 chr17:30273784 C/T cg20587970 chr11:113659929 NA -1.43 -20.42 -0.75 2e-60 Hip circumference adjusted for BMI; CRC trans rs17685 0.712 rs7785025 chr7:75628101 C/T cg19862616 chr7:65841803 NCRNA00174 -0.97 -18.05 -0.71 4e-51 Coffee consumption;Coffee consumption (cups per day); CRC cis rs1865760 1.000 rs7757666 chr6:25902626 T/C cg16482183 chr6:26056742 HIST1H1C 0.55 7.97 0.4 2.55e-14 Height; CRC cis rs4689388 0.853 rs13108780 chr4:6294630 A/G cg00701064 chr4:6280414 WFS1 0.75 13.24 0.59 2.21e-32 Type 2 diabetes and other traits;Type 2 diabetes; CRC cis rs13118159 0.573 rs7664763 chr4:1352305 A/G cg16405210 chr4:1374714 KIAA1530 -0.92 -14.48 -0.62 4.3e-37 Longevity; CRC cis rs747650 0.504 rs12417519 chr11:47129397 C/T cg19486271 chr11:47235900 DDB2 0.44 5.84 0.31 1.23e-8 Acne (severe); CRC cis rs11997175 0.624 rs4733175 chr8:33679744 T/A ch.8.33884649F chr8:33765107 NA 0.44 6.26 0.33 1.23e-9 Body mass index; CRC cis rs4700695 0.511 rs29443 chr5:65504927 G/A cg21114390 chr5:65439923 SFRS12 -0.54 -7.53 -0.38 4.99e-13 Facial morphology (factor 19); CRC cis rs7640424 0.929 rs17828045 chr3:107821546 A/C cg09227934 chr3:107805635 CD47 -0.46 -6.74 -0.35 7.2e-11 Body mass index; CRC cis rs8014671 0.597 rs8021180 chr14:70783943 A/G cg25576086 chr14:70833871 SYNJ2BP -0.38 -6.85 -0.35 3.64e-11 Prostate cancer; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg09581281 chr1:15853227 DNAJC16 0.5 6.45 0.34 3.99e-10 Thyroid stimulating hormone; CRC cis rs10979 0.964 rs9496683 chr6:143898845 G/A cg25407410 chr6:143891975 LOC285740 -0.85 -13.99 -0.61 3.18e-35 Hypospadias; CRC trans rs6749447 0.848 rs4668029 chr2:169008965 T/C cg01878807 chr14:24422368 DHRS4;C14orf167 0.39 6.02 0.31 4.61e-9 Blood pressure; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg27308707 chr10:91461150 KIF20B 0.38 6.47 0.34 3.54e-10 Liver disease severity in Alagille syndrome; CRC cis rs1065656 0.571 rs12149777 chr16:1834724 A/G cg08610935 chr16:1836813 NUBP2 -0.57 -9.14 -0.45 6.61e-18 Insulin-like growth factors; CRC cis rs1218582 0.772 rs4845688 chr1:154884142 T/C cg09359103 chr1:154839909 KCNN3 -0.7 -12.36 -0.56 4.21e-29 Prostate cancer; CRC cis rs9039 0.550 rs12924785 chr16:9219285 T/G cg08831531 chr16:9218945 NA -0.39 -5.65 -0.3 3.51e-8 Menopause (age at onset); CRC cis rs2708240 0.666 rs2710118 chr7:147603362 A/C cg02373104 chr7:147601429 MIR548F3;CNTNAP2 -0.41 -5.94 -0.31 7.2e-9 QT interval (drug interaction); CRC cis rs9467773 0.596 rs62396201 chr6:26668216 G/A cg09904177 chr6:26538194 HMGN4 0.68 10.54 0.5 1.47e-22 Intelligence (multi-trait analysis); CRC cis rs4474465 0.850 rs10899545 chr11:78250371 C/T cg27205649 chr11:78285834 NARS2 0.51 6.58 0.34 1.9e-10 Alzheimer's disease (survival time); CRC trans rs2303319 0.504 rs62187609 chr2:162431500 C/T cg14875682 chr5:52083620 ITGA1;PELO -0.8 -6.48 -0.34 3.35e-10 Cognitive function; CRC cis rs5769707 0.967 rs5770585 chr22:50007874 G/A cg20744362 chr22:50050164 C22orf34 0.34 6.71 0.35 8.74e-11 Monocyte count;Monocyte percentage of white cells; CRC cis rs611744 0.573 rs674580 chr8:109251690 C/G cg21045802 chr8:109455806 TTC35 0.46 7.05 0.36 1.06e-11 Dupuytren's disease; CRC cis rs79149102 0.579 rs61166993 chr15:75306644 C/A cg15902774 chr15:75289873 SCAMP5 0.5 5.77 0.3 1.83e-8 Lung cancer; CRC cis rs1670533 1.000 rs6827357 chr4:1059202 A/C cg27284194 chr4:1044797 NA 0.51 6.61 0.34 1.52e-10 Recombination rate (females); CRC trans rs916888 0.821 rs199506 chr17:44859031 A/G cg01341218 chr17:43662625 NA -0.83 -9.29 -0.46 2.18e-18 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs12586317 0.547 rs45531432 chr14:35484423 C/T cg16230307 chr14:35515116 FAM177A1 0.87 10.25 0.49 1.43e-21 Psoriasis; CRC trans rs2727020 0.704 rs4144700 chr11:49370834 C/A cg11707556 chr5:10655725 ANKRD33B -0.36 -6.63 -0.34 1.36e-10 Coronary artery disease; CRC trans rs2303319 0.504 rs56407015 chr2:162455625 G/A cg15664909 chr17:685709 GLOD4;RNMTL1 -0.67 -5.96 -0.31 6.48e-9 Cognitive function; CRC cis rs9906944 0.545 rs1994969 chr17:47080431 G/T cg10950924 chr17:47092072 IGF2BP1 -0.42 -6.7 -0.35 9.15e-11 Intelligence (multi-trait analysis);Body fat percentage; CRC cis rs1552244 1.000 rs6764068 chr3:10153842 A/G cg13047869 chr3:10149882 C3orf24 0.58 7.8 0.39 8.47e-14 Alzheimer's disease; CRC cis rs1067327 1 rs1067327 chr2:44628529 C/G cg04920474 chr2:44395004 PPM1B 0.41 6.04 0.32 4.26e-9 Anxiety disorder (factor score); CRC cis rs10256972 0.641 rs12702017 chr7:1129413 C/T cg04025307 chr7:1156635 C7orf50 0.71 11.49 0.54 6.39e-26 Longevity;Endometriosis; CRC cis rs9372498 0.536 rs62422229 chr6:118959288 T/C cg07617317 chr6:118971624 C6orf204 0.47 5.76 0.3 1.98e-8 Diastolic blood pressure; CRC cis rs3806843 1.000 rs9686540 chr5:140174622 G/A cg16607685 chr5:140181889 PCDHA2;PCDHA1;PCDHA3 -0.26 -5.97 -0.31 6.06e-9 Depressive symptoms (multi-trait analysis); CRC cis rs6460942 0.841 rs17443848 chr7:12443688 A/G cg02935154 chr7:12443704 VWDE -0.44 -6.18 -0.32 1.94e-9 Coronary artery disease; CRC trans rs7521492 0.783 rs1932356 chr1:163714823 G/T cg23417011 chr5:93077375 FAM172A;POU5F2 -0.4 -6.02 -0.31 4.65e-9 Autism spectrum disorder or schizophrenia;Schizophrenia; CRC cis rs7147624 1.000 rs1009465 chr14:65970370 G/C cg03016385 chr14:66212404 NA -1.02 -10.59 -0.5 9.73e-23 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs2836974 0.644 rs719230 chr21:40676307 C/T cg17971929 chr21:40555470 PSMG1 -0.71 -10.86 -0.51 1.11e-23 Cognitive function; CRC cis rs8180040 0.903 rs6791842 chr3:47279810 T/C cg27129171 chr3:47204927 SETD2 0.72 12.03 0.55 7.11e-28 Colorectal cancer; CRC cis rs861020 1.000 rs632746 chr1:209982515 C/T cg09163369 chr1:210001066 C1orf107 0.6 7.72 0.39 1.37e-13 Orofacial clefts; CRC cis rs10504229 0.683 rs62621195 chr8:58133964 G/A cg22535103 chr8:58192502 C8orf71 -0.7 -9.34 -0.46 1.47e-18 Developmental language disorder (linguistic errors); CRC cis rs728616 0.867 rs17098720 chr10:81840236 A/G cg05935833 chr10:81318306 SFTPA2 -0.55 -6.55 -0.34 2.18e-10 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs8180040 0.726 rs4682837 chr3:46999707 C/T cg02527881 chr3:46936655 PTH1R -0.43 -8.16 -0.41 7.21e-15 Colorectal cancer; CRC cis rs2439831 0.850 rs7179388 chr15:44123945 C/G cg02155558 chr15:43621948 ADAL;LCMT2 0.7 7.27 0.37 2.62e-12 Lung cancer in ever smokers; CRC cis rs514406 0.505 rs387436 chr1:53179376 C/T cg25767906 chr1:53392781 SCP2 0.41 6.3 0.33 9.75e-10 Monocyte count; CRC cis rs13315871 1.000 rs13096020 chr3:58367771 G/A cg20936604 chr3:58311152 NA -0.75 -6.89 -0.35 2.89e-11 Cholesterol, total; CRC cis rs12142240 0.698 rs66847432 chr1:46832013 G/A cg00530320 chr1:46809349 NSUN4 0.59 8.11 0.41 1.02e-14 Menopause (age at onset); CRC cis rs13118159 0.742 rs34947293 chr4:1335034 T/C cg24560729 chr4:1342394 KIAA1530 0.43 7.84 0.4 6.44e-14 Longevity; CRC cis rs2270875 1.000 rs10464872 chr8:132932749 A/G cg24184792 chr8:132919238 EFR3A -0.68 -6.87 -0.35 3.14e-11 Response to cholinesterase inhibitors in Alzheimer's disease; CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg04513197 chr1:100504319 HIAT1 -0.52 -6.17 -0.32 1.99e-9 Diisocyanate-induced asthma; CRC cis rs7659604 0.539 rs3217773 chr4:122739121 A/G cg19748678 chr4:122722346 EXOSC9 0.65 10.31 0.49 8.54e-22 Type 2 diabetes; CRC cis rs67385638 0.802 rs72872555 chr11:5310169 G/A cg21506790 chr11:5277210 HBG2 0.35 5.69 0.3 2.84e-8 Hemoglobin levels; CRC cis rs7904368 0.806 rs7899923 chr10:16857394 G/A cg14835575 chr10:16859367 RSU1 0.45 6.05 0.32 4.04e-9 Ratio of the peak velocity of the mitral E-Wave divided by the peak velocity of the mitral A-wave.; CRC cis rs56399783 0.901 rs73033403 chr7:2877941 G/A cg19731401 chr7:2775893 GNA12 0.6 6.32 0.33 8.44e-10 Childhood ear infection; CRC cis rs9467160 0.871 rs13205780 chr6:24448687 C/T cg20631270 chr6:24437470 GPLD1 0.48 6.66 0.34 1.13e-10 Liver enzyme levels; CRC cis rs611744 0.647 rs10106246 chr8:109268710 T/C cg21045802 chr8:109455806 TTC35 0.42 6.63 0.34 1.34e-10 Dupuytren's disease; CRC cis rs6860806 0.507 rs582490 chr5:131710095 G/A cg09877947 chr5:131593287 PDLIM4 -0.44 -7.11 -0.37 7.08e-12 Breast cancer; CRC cis rs5758511 0.689 rs11913578 chr22:42347391 A/C cg00645731 chr22:42541494 CYP2D7P1 0.45 6.87 0.35 3.21e-11 Birth weight; CRC cis rs2797160 1.000 rs4895798 chr6:126000162 A/G cg05901451 chr6:126070800 HEY2 -0.38 -5.93 -0.31 7.46e-9 Endometrial cancer; CRC cis rs10504229 0.554 rs17802082 chr8:58095867 C/T cg11062466 chr8:58055876 NA 0.46 6.22 0.32 1.51e-9 Developmental language disorder (linguistic errors); CRC cis rs9611565 0.512 rs9607841 chr22:42186838 G/A cg06634786 chr22:41940651 POLR3H -0.7 -7.81 -0.4 7.8e-14 Vitiligo; CRC cis rs6496667 1.000 rs7182544 chr15:90897480 G/C cg04176472 chr15:90893244 GABARAPL3 0.52 7.95 0.4 3.04e-14 Rheumatoid arthritis; CRC trans rs2727020 0.521 rs7107178 chr11:49526668 G/A cg11707556 chr5:10655725 ANKRD33B 0.47 7.51 0.38 5.68e-13 Coronary artery disease; CRC cis rs2153535 0.580 rs969421 chr6:8451949 A/C cg07606381 chr6:8435919 SLC35B3 0.68 10.85 0.51 1.2e-23 Motion sickness; CRC cis rs3093024 1.000 rs3093023 chr6:167534290 A/G cg19688584 chr6:167529678 CCR6 -0.33 -5.82 -0.31 1.42e-8 Rheumatoid arthritis; CRC cis rs1707322 1.000 rs7519181 chr1:46387829 G/C cg03146154 chr1:46216737 IPP 0.5 7.04 0.36 1.12e-11 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs6024905 0.587 rs1579101 chr20:36966334 C/T cg07053727 chr20:36965646 BPI 0.74 14.39 0.62 9.52e-37 Bipolar disorder and schizophrenia; CRC cis rs7412746 0.658 rs2089082 chr1:150800090 T/G cg15448220 chr1:150897856 SETDB1 0.56 8.11 0.41 1.03e-14 Melanoma; CRC cis rs7923452 0.507 rs103441 chr10:30778184 C/T cg18806716 chr10:30721971 MAP3K8 -0.56 -7.34 -0.38 1.67e-12 Itch intensity from mosquito bite; CRC cis rs853679 0.513 rs13437444 chr6:28070998 C/T cg15786705 chr6:28176104 NA 0.71 7.18 0.37 4.59e-12 Depression; CRC cis rs11168351 0.750 rs11168366 chr12:48421773 T/C cg00601486 chr12:48723148 H1FNT -0.34 -6.46 -0.34 3.88e-10 Bipolar disorder and schizophrenia; CRC cis rs7727544 1.000 rs7727544 chr5:131590534 C/T cg04518342 chr5:131593106 PDLIM4 0.38 7.1 0.36 7.78e-12 Blood metabolite levels; CRC cis rs13118159 0.573 rs4974618 chr4:1373663 C/T cg05025164 chr4:1340916 KIAA1530 0.53 7.51 0.38 5.69e-13 Longevity; CRC cis rs7591163 1.000 rs4300818 chr2:228713255 G/T cg08034379 chr2:228736324 WDR69 -0.53 -7.22 -0.37 3.59e-12 Blood pressure; CRC cis rs7091068 1.000 rs7091068 chr10:95420385 G/T cg20715218 chr10:95462985 C10orf4 0.54 5.71 0.3 2.52e-8 Urinary tract infection frequency; CRC cis rs9326248 1.000 rs664971 chr11:117070857 A/G cg15534755 chr11:117069859 TAGLN -0.36 -6.94 -0.36 2.03e-11 Blood protein levels; CRC cis rs10045504 0.502 rs72746043 chr5:38757226 T/C cg15396434 chr5:38725168 NA -0.63 -6.22 -0.32 1.53e-9 Night sleep phenotypes; CRC cis rs11148252 0.774 rs7993748 chr13:52941631 C/T cg02158880 chr13:53174818 NA 0.46 7.06 0.36 9.87e-12 Lewy body disease; CRC cis rs875971 0.830 rs4718358 chr7:65973668 T/C cg18876405 chr7:65276391 NA 0.5 8.49 0.42 7.31e-16 Aortic root size; CRC cis rs7618501 0.665 rs7621352 chr3:50070763 A/C cg05623727 chr3:50126028 RBM5 -0.45 -7.37 -0.38 1.4e-12 Intelligence (multi-trait analysis); CRC cis rs9303280 0.806 rs4795399 chr17:38061439 T/C cg17344932 chr17:38183730 MED24;SNORD124 0.39 6.22 0.32 1.48e-9 Self-reported allergy; CRC cis rs9491140 0.539 rs980658 chr6:124690371 G/A cg19267163 chr6:125004984 NKAIN2 0.44 5.93 0.31 7.78e-9 Neuroticism; CRC cis rs7309 0.935 rs11884495 chr2:162059969 A/T cg21518248 chr2:162101506 NA 0.45 6.63 0.34 1.41e-10 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Educational attainment; CRC cis rs2859741 0.528 rs6686296 chr1:37489380 G/T cg09363841 chr1:37513479 NA 0.47 7.35 0.38 1.61e-12 Forced expiratory volume in 1 second (environmental tobacco smoke interaction); CRC cis rs7727544 0.526 rs4705908 chr5:131347520 G/A cg12564285 chr5:131593104 PDLIM4 0.32 5.67 0.3 3.08e-8 Blood metabolite levels; CRC cis rs4731207 0.698 rs2158677 chr7:124443966 T/C cg23710748 chr7:124431027 NA 0.37 5.96 0.31 6.53e-9 Cutaneous malignant melanoma; CRC cis rs11676348 0.818 rs6436031 chr2:218979259 T/C cg00012203 chr2:219082015 ARPC2 -0.43 -6.25 -0.33 1.26e-9 Ulcerative colitis; CRC cis rs427941 0.703 rs201440 chr7:101735599 C/T cg06246474 chr7:101738831 CUX1 0.45 7.06 0.36 9.83e-12 Plasma omega-3 polyunsaturated fatty acid level (eicosapentaenoic acid); CRC cis rs853679 0.517 rs9393884 chr6:28046789 A/G cg12273811 chr6:28175739 NA 0.68 8.75 0.43 1.1e-16 Depression; CRC cis rs9814567 1.000 rs9884031 chr3:134256500 C/T cg06541857 chr3:134203789 ANAPC13;CEP63 -0.4 -6.06 -0.32 3.66e-9 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs11229555 0.874 rs11605269 chr11:58350872 A/G cg15696309 chr11:58395628 NA -0.95 -12.73 -0.57 1.82e-30 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; CRC cis rs897984 0.806 rs9319588 chr16:30930983 C/T cg00531865 chr16:30841666 NA 0.49 6.98 0.36 1.66e-11 Dementia with Lewy bodies; CRC cis rs58688157 0.705 rs7112149 chr11:595890 G/A cg01842473 chr11:617407 IRF7;MUPCDH -0.56 -6.66 -0.34 1.18e-10 Systemic lupus erythematosus; CRC cis rs4604732 0.631 rs74154673 chr1:247625629 G/A cg12754571 chr1:247694271 LOC148824;OR2C3 0.41 5.78 0.3 1.74e-8 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CRC cis rs6714710 0.603 rs13020776 chr2:98402753 T/A cg26665480 chr2:98280029 ACTR1B 0.52 7.16 0.37 5.23e-12 Posterior cortical atrophy and Alzheimer's disease; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg13516796 chr16:5122251 ALG1 0.51 6.6 0.34 1.63e-10 Thyroid stimulating hormone; CRC cis rs847851 0.630 rs9469905 chr6:34797747 G/A cg07306190 chr6:34760872 UHRF1BP1 -0.35 -6.13 -0.32 2.45e-9 Colonoscopy-negative controls vs population controls; CRC trans rs9291683 0.588 rs13121211 chr4:9999539 A/G cg26043149 chr18:55253948 FECH 0.49 7.89 0.4 4.57e-14 Bone mineral density; CRC trans rs2303319 0.504 rs62188960 chr2:162492578 A/C cg04269497 chr6:167369491 RNASET2 -0.74 -6.06 -0.32 3.72e-9 Cognitive function; CRC cis rs10504229 0.683 rs7464038 chr8:58111908 T/C cg24829409 chr8:58192753 C8orf71 -0.56 -7.83 -0.4 6.86e-14 Developmental language disorder (linguistic errors); CRC cis rs875971 0.861 rs801215 chr7:66011938 A/T cg18876405 chr7:65276391 NA -0.52 -8.44 -0.42 9.94e-16 Aortic root size; CRC trans rs12210905 1.000 rs9379967 chr6:27233427 T/C cg05005425 chr1:167687389 NA 0.62 6.33 0.33 8.22e-10 Hip circumference adjusted for BMI; CRC cis rs6951245 1.000 rs1881123 chr7:1084706 C/T cg03188948 chr7:1209495 NA 0.64 6.59 0.34 1.72e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs28386778 0.966 rs2008053 chr17:61954918 G/C cg23090583 chr17:61904693 PSMC5;FTSJ3 0.98 18.63 0.72 2.17e-53 Prudent dietary pattern; CRC cis rs9487051 0.872 rs6924776 chr6:109612276 A/G cg01475377 chr6:109611718 NA -0.49 -9.33 -0.46 1.65e-18 Reticulocyte fraction of red cells; CRC cis rs4819052 1.000 rs3746980 chr21:46711580 C/T cg02159808 chr21:46707872 POFUT2;LOC642852 0.69 8.5 0.42 6.53e-16 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs17270561 0.583 rs12662869 chr6:25784481 A/C cg17691542 chr6:26056736 HIST1H1C -0.56 -7.82 -0.4 7.12e-14 Iron status biomarkers; CRC cis rs7647973 1.000 rs7619789 chr3:49476263 T/C cg07636037 chr3:49044803 WDR6 0.66 8.09 0.41 1.14e-14 Menarche (age at onset); CRC trans rs1005277 0.541 rs2472177 chr10:38384015 T/G cg17830980 chr10:43048298 ZNF37B -0.56 -9.5 -0.46 4.53e-19 Extrinsic epigenetic age acceleration; CRC cis rs651907 0.557 rs2303474 chr3:101371899 G/T cg12386194 chr3:101231763 SENP7 0.48 6.77 0.35 5.91e-11 Colorectal cancer; CRC trans rs800082 0.501 rs9873732 chr3:144191665 C/T cg24215973 chr2:240111563 HDAC4 0.57 8.56 0.43 4.53e-16 Smoking behavior; CRC cis rs853679 0.882 rs9380064 chr6:28143118 A/G cg06470822 chr6:28175283 NA 0.78 6.19 0.32 1.76e-9 Depression; CRC cis rs10504229 0.728 rs17804720 chr8:58154565 T/C cg08219700 chr8:58056026 NA 0.45 5.74 0.3 2.11e-8 Developmental language disorder (linguistic errors); CRC cis rs7474896 0.559 rs1024202 chr10:38278977 A/C cg25427524 chr10:38739819 LOC399744 0.59 7.3 0.37 2.14e-12 Obesity (extreme); CRC cis rs2859741 0.967 rs534131 chr1:37484237 T/C cg09363841 chr1:37513479 NA -0.61 -11.43 -0.53 1.09e-25 Forced expiratory volume in 1 second (environmental tobacco smoke interaction); CRC cis rs2033711 0.870 rs1051500 chr19:58944402 A/G cg00825309 chr19:58991885 ZNF446 -0.46 -6.57 -0.34 2.03e-10 Uric acid clearance; CRC cis rs4148883 0.737 rs13148577 chr4:100060836 G/A cg12011299 chr4:100065546 ADH4 0.54 12.03 0.55 6.94e-28 Alcohol dependence; CRC cis rs8180040 0.654 rs6766230 chr3:47196209 C/A cg02527881 chr3:46936655 PTH1R -0.35 -6.09 -0.32 3.07e-9 Colorectal cancer; CRC cis rs1005277 0.579 rs2474572 chr10:38385316 A/G cg03665457 chr10:38645376 HSD17B7P2 -0.42 -6.03 -0.32 4.49e-9 Extrinsic epigenetic age acceleration; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg14277917 chr14:59655363 DAAM1 0.39 6.19 0.32 1.77e-9 Liver disease severity in Alagille syndrome; CRC trans rs2303319 0.504 rs62189052 chr2:162623869 C/G cg22627826 chr19:1240265 ATP5D -0.72 -6.24 -0.33 1.37e-9 Cognitive function; CRC cis rs6952808 0.601 rs3800882 chr7:2120758 G/A cg02951883 chr7:2050386 MAD1L1 -0.57 -9.07 -0.45 1.14e-17 Bipolar disorder and schizophrenia; CRC cis rs6860806 0.507 rs156322 chr5:131653925 C/T cg09877947 chr5:131593287 PDLIM4 0.43 6.72 0.35 7.93e-11 Breast cancer; CRC cis rs1707322 1.000 rs1768800 chr1:46549188 A/G cg06784218 chr1:46089804 CCDC17 -0.55 -9.67 -0.47 1.26e-19 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs853679 0.517 rs9393897 chr6:28127710 G/T cg06470822 chr6:28175283 NA 1.03 13.59 0.6 1.04e-33 Depression; CRC cis rs612683 0.602 rs2030048 chr1:101006577 C/T cg06223162 chr1:101003688 GPR88 -0.37 -6.79 -0.35 5.11e-11 Breast cancer; CRC cis rs1046896 0.553 rs72634343 chr17:80827392 T/C cg16060761 chr17:80687452 NA -0.47 -6.1 -0.32 2.91e-9 Glycated hemoglobin levels; CRC cis rs75422866 0.510 rs73105803 chr12:48115918 G/A cg14736327 chr12:48174669 SLC48A1 -0.72 -5.75 -0.3 2.05e-8 Pneumonia; CRC cis rs45544231 0.569 rs4784224 chr16:52580247 C/A cg09051775 chr16:52580266 TOX3 -0.41 -6.62 -0.34 1.44e-10 Restless legs syndrome; CRC cis rs7772486 0.641 rs2748489 chr6:146331287 T/G cg13319975 chr6:146136371 FBXO30 -0.55 -7.72 -0.39 1.39e-13 Lobe attachment (rater-scored or self-reported); CRC cis rs9491140 0.539 rs11751246 chr6:124692967 C/T cg19267163 chr6:125004984 NKAIN2 0.47 6.11 0.32 2.79e-9 Neuroticism; CRC cis rs3008870 1.000 rs1925411 chr1:67370292 C/T cg08660285 chr1:67390436 MIER1;WDR78 1.04 15.76 0.66 4.52e-42 Lymphocyte percentage of white cells; CRC cis rs2243480 1.000 rs56016656 chr7:65383481 C/T cg18252515 chr7:66147081 NA -1.12 -12.72 -0.57 2.06e-30 Diabetic kidney disease; CRC cis rs1865760 0.602 rs9467662 chr6:26021327 G/A cg18357526 chr6:26021779 HIST1H4A 0.45 6.38 0.33 6.12e-10 Height; CRC cis rs1348850 0.872 rs7559521 chr2:178452328 A/G cg02961200 chr2:178257176 LOC100130691;AGPS -0.47 -6.58 -0.34 1.82e-10 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs2404602 0.647 rs55778276 chr15:77136590 T/A cg23625390 chr15:77176239 SCAPER -0.85 -12.62 -0.57 4.91e-30 Blood metabolite levels; CRC cis rs6988636 1.000 rs58177772 chr8:124188067 T/C cg27053337 chr8:124217698 FAM83A 0.48 7.04 0.36 1.11e-11 Urinary uromodulin levels; CRC cis rs4713118 0.786 rs200502 chr6:27788062 C/T cg03623178 chr6:28175578 NA 0.73 9.19 0.45 4.45e-18 Parkinson's disease; CRC cis rs6456156 0.586 rs7761977 chr6:167485678 A/G cg07741184 chr6:167504864 NA 0.38 6.65 0.34 1.21e-10 Primary biliary cholangitis; CRC cis rs1801251 1.000 rs283484 chr2:233646505 A/G cg25237894 chr2:233734115 C2orf82 0.55 8.92 0.44 3.33e-17 Coronary artery disease; CRC cis rs853679 0.517 rs4713141 chr6:28101678 G/C cg25164649 chr6:28176230 NA 0.76 9.53 0.46 3.71e-19 Depression; CRC cis rs1059312 0.808 rs2306683 chr12:129299675 C/G cg23521905 chr12:129298690 SLC15A4;MGC16384 0.38 6.58 0.34 1.8e-10 Systemic lupus erythematosus; CRC cis rs4689388 0.889 rs10026334 chr4:6294607 G/A cg00701064 chr4:6280414 WFS1 0.75 13.24 0.59 2.21e-32 Type 2 diabetes and other traits;Type 2 diabetes; CRC cis rs6495122 0.501 rs6495151 chr15:75385990 A/G cg09165964 chr15:75287851 SCAMP5 -0.5 -7.94 -0.4 3.33e-14 Caffeine consumption;Diastolic blood pressure;Coffee consumption; CRC cis rs11212617 0.934 rs595747 chr11:108194073 C/T cg14761454 chr11:108092087 ATM;NPAT 0.39 5.67 0.3 3.11e-8 Response to metformin in type 2 diabetes (glycemic); CRC cis rs7589728 1.000 rs6722069 chr2:88533151 C/T cg24977027 chr2:88469347 THNSL2 0.55 6.52 0.34 2.69e-10 Plasma clusterin levels; CRC cis rs1799949 0.965 rs4239149 chr17:41328095 A/G cg19454999 chr17:41278357 BRCA1;NBR2 -0.41 -6.32 -0.33 8.72e-10 Menopause (age at onset); CRC cis rs1707322 0.721 rs10789470 chr1:46158331 T/G cg06784218 chr1:46089804 CCDC17 0.66 12.38 0.56 3.81e-29 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs2180341 0.960 rs1964130 chr6:127677391 C/G cg27446573 chr6:127587934 RNF146 0.87 12.3 0.56 7.52e-29 Breast cancer; CRC cis rs35306767 0.807 rs72778228 chr10:938435 A/G cg20503657 chr10:835505 NA 1.24 14.88 0.63 1.14e-38 Eosinophil percentage of granulocytes; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg14057772 chr17:21178963 NA 0.44 6.48 0.34 3.27e-10 Liver disease severity in Alagille syndrome; CRC cis rs6598955 0.724 rs7526545 chr1:26569990 C/A cg04990556 chr1:26633338 UBXN11 -0.79 -13.37 -0.59 7.65e-33 Obesity-related traits; CRC cis rs7224737 0.956 rs8081327 chr17:40274200 G/A cg02450064 chr17:40260053 DHX58 -0.43 -6.13 -0.32 2.55e-9 Fibrinogen levels; CRC cis rs7224685 0.501 rs781848 chr17:3958105 A/C cg10724054 chr17:3904396 NA -0.42 -6.64 -0.34 1.28e-10 Type 2 diabetes; CRC cis rs6681460 0.966 rs10889643 chr1:67143368 G/C cg02459107 chr1:67143332 SGIP1 0.46 7.98 0.4 2.52e-14 Presence of antiphospholipid antibodies; CRC cis rs11650494 0.908 rs73324308 chr17:47405338 T/G cg08112188 chr17:47440006 ZNF652 1.19 11.24 0.53 5e-25 Prostate cancer; CRC cis rs1881797 0.872 rs12404733 chr1:247690417 A/C cg05639522 chr1:247681581 NA 0.45 6.99 0.36 1.53e-11 Acute lymphoblastic leukemia (childhood); CRC cis rs8060686 0.641 rs76646352 chr16:68044797 C/A cg08314208 chr16:67682810 RLTPR -0.66 -6.85 -0.35 3.64e-11 HDL cholesterol;Metabolic syndrome; CRC cis rs1448094 0.512 rs61930861 chr12:86245023 G/T cg18827107 chr12:86230957 RASSF9 -0.45 -7.42 -0.38 9.97e-13 Major depressive disorder; CRC cis rs7071206 0.947 rs716255 chr10:79419679 A/T cg07817648 chr10:79422355 NA -0.71 -9.28 -0.46 2.33e-18 Bone mineral density; CRC cis rs10504229 0.610 rs7011877 chr8:58147181 C/T cg22535103 chr8:58192502 C8orf71 -0.66 -9.45 -0.46 6.59e-19 Developmental language disorder (linguistic errors); CRC cis rs9322193 0.923 rs9688350 chr6:150052113 A/T cg07701084 chr6:150067640 NUP43 0.57 8.11 0.41 9.94e-15 Lung cancer; CRC cis rs4423214 1.000 rs12785878 chr11:71167449 G/T cg05163923 chr11:71159392 DHCR7 0.65 9.25 0.45 2.99e-18 Vitamin D levels; CRC cis rs7917772 0.636 rs4919674 chr10:104522226 T/C cg04362960 chr10:104952993 NT5C2 0.46 6.18 0.32 1.85e-9 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC cis rs12142240 0.698 rs1135460 chr1:46815970 T/C cg00530320 chr1:46809349 NSUN4 0.57 7.75 0.39 1.19e-13 Menopause (age at onset); CRC cis rs2811415 0.597 rs12695506 chr3:127791800 A/G cg13719885 chr3:127795394 NA -0.39 -5.94 -0.31 7.28e-9 Lung function (FEV1/FVC); CRC cis rs11249608 0.548 rs6860309 chr5:178451428 T/C cg01312482 chr5:178451176 ZNF879 -0.36 -6.02 -0.32 4.54e-9 Pubertal anthropometrics; CRC cis rs6570726 0.935 rs408723 chr6:145838535 A/G cg23711669 chr6:146136114 FBXO30 0.68 12.16 0.56 2.33e-28 Lobe attachment (rater-scored or self-reported); CRC cis rs4363385 0.747 rs4319267 chr1:152972699 T/G cg25856811 chr1:152973957 SPRR3 -0.26 -7.22 -0.37 3.62e-12 Inflammatory skin disease; CRC cis rs883565 0.569 rs1274973 chr3:39160441 G/A cg01426195 chr3:39028469 NA -0.42 -7.0 -0.36 1.4e-11 Handedness; CRC cis rs6772849 0.805 rs61159406 chr3:128336009 G/A cg08795948 chr3:128337044 NA 0.34 6.03 0.32 4.38e-9 Monocyte percentage of white cells;Monocyte count; CRC cis rs9487051 0.676 rs7753705 chr6:109593302 A/C cg21918786 chr6:109611834 NA -0.41 -7.17 -0.37 4.84e-12 Reticulocyte fraction of red cells; CRC cis rs60871478 1.000 rs60871478 chr7:827325 A/G cg13844804 chr7:814759 HEATR2 0.63 8.23 0.41 4.49e-15 Cerebrospinal P-tau181p levels; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg20959894 chr7:27779871 TAX1BP1 0.4 6.81 0.35 4.71e-11 Liver disease severity in Alagille syndrome; CRC cis rs7103648 0.545 rs6485795 chr11:47929846 G/A cg20307385 chr11:47447363 PSMC3 0.73 9.9 0.48 2.08e-20 Diastolic blood pressure;Systolic blood pressure; CRC cis rs514406 0.668 rs1672911 chr1:53340320 T/C cg24675658 chr1:53192096 ZYG11B -0.7 -10.34 -0.5 6.98e-22 Monocyte count; CRC cis rs4319547 0.661 rs7398014 chr12:122943980 T/C cg23029597 chr12:123009494 RSRC2 -0.61 -7.54 -0.38 4.64e-13 Body mass index; CRC cis rs853679 0.517 rs4711165 chr6:28115184 T/G cg03623178 chr6:28175578 NA 0.98 12.66 0.57 3.31e-30 Depression; CRC cis rs10504229 0.724 rs58715581 chr8:58134568 A/G cg24829409 chr8:58192753 C8orf71 -0.55 -8.03 -0.4 1.71e-14 Developmental language disorder (linguistic errors); CRC trans rs2727020 0.729 rs10742932 chr11:49173234 T/C cg03929089 chr4:120376271 NA -0.76 -12.44 -0.57 2.27e-29 Coronary artery disease; CRC cis rs796364 1.000 rs11895190 chr2:200838613 A/G cg25936922 chr2:200820526 C2orf60;C2orf47 -0.72 -7.74 -0.39 1.22e-13 Schizophrenia; CRC cis rs6912958 0.781 rs3757368 chr6:88224495 T/C cg08069147 chr6:88032118 GJB7;C6orf162 -0.55 -8.26 -0.41 3.58e-15 Monocyte percentage of white cells; CRC trans rs12699921 0.632 rs2691613 chr7:17883981 G/A cg15753394 chr6:17282781 RBM24 -0.36 -6.18 -0.32 1.86e-9 Fibrinogen levels; CRC cis rs62229266 0.804 rs62230821 chr21:37425116 C/T cg08632701 chr21:37451849 NA -0.45 -7.15 -0.37 5.77e-12 Mitral valve prolapse; CRC cis rs6502050 0.799 rs8082355 chr17:80120316 A/G cg13198984 chr17:80129470 CCDC57 0.47 8.35 0.42 1.88e-15 Life satisfaction; CRC cis rs881375 0.967 rs7864019 chr9:123692868 A/T cg09586646 chr9:123605570 PSMD5;LOC253039 0.47 6.49 0.34 3.2e-10 Rheumatoid arthritis; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg15229027 chr14:64805542 ESR2 0.46 6.77 0.35 5.77e-11 Response to antipsychotic treatment; CRC cis rs2153535 0.601 rs1855768 chr6:8472969 T/G cg07606381 chr6:8435919 SLC35B3 0.68 10.9 0.51 8.26e-24 Motion sickness; CRC cis rs34779708 0.931 rs4934721 chr10:35377715 A/G cg03585969 chr10:35415529 CREM 0.66 8.79 0.44 8.32e-17 Inflammatory bowel disease;Crohn's disease; CRC cis rs2976388 0.590 rs3758082 chr8:143824483 A/G cg22687807 chr8:143858763 LYNX1 -0.45 -7.44 -0.38 9.07e-13 Urinary tract infection frequency; CRC cis rs10504229 0.679 rs7839948 chr8:58130607 A/G cg04204079 chr8:58130323 NA -0.45 -5.78 -0.3 1.71e-8 Developmental language disorder (linguistic errors); CRC cis rs9325144 0.647 rs10875953 chr12:39050536 G/C cg26384229 chr12:38710491 ALG10B -0.53 -7.46 -0.38 7.59e-13 Morning vs. evening chronotype; CRC cis rs875971 1.000 rs6957199 chr7:65978519 T/C cg18876405 chr7:65276391 NA 0.52 8.89 0.44 4.13e-17 Aortic root size; CRC cis rs11785400 0.793 rs9297969 chr8:143723237 A/G cg24634471 chr8:143751801 JRK 0.51 7.08 0.36 8.81e-12 Schizophrenia; CRC trans rs1656966 1.000 rs1656966 chr3:186466252 C/T cg06173978 chr16:50402162 BRD7 0.37 6.43 0.33 4.53e-10 Myopia (pathological); CRC cis rs447 0.806 rs6651129 chr7:83729251 T/G cg22846510 chr7:83753280 SEMA3A -0.51 -6.19 -0.32 1.81e-9 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg08135327 chr2:134877962 NA 0.43 7.13 0.37 6.22e-12 Liver disease severity in Alagille syndrome; CRC cis rs4363385 0.747 rs6668696 chr1:152964910 A/G cg25856811 chr1:152973957 SPRR3 -0.26 -7.2 -0.37 4.17e-12 Inflammatory skin disease; CRC trans rs2547917 0.947 rs2702376 chr5:58707592 C/G cg19319774 chr19:51870582 CLDND2;ETFB -0.57 -6.06 -0.32 3.82e-9 Adverse response to chemotherapy (neutropenia/leucopenia) (gemcitabine); CRC cis rs2739330 0.760 rs5760095 chr22:24247293 A/G cg10150615 chr22:24372951 LOC391322 -0.58 -8.44 -0.42 1.01e-15 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs7274811 0.625 rs169797 chr20:31926490 G/A cg03904042 chr20:32255491 NECAB3;C20orf134 0.46 6.54 0.34 2.41e-10 Height; CRC cis rs1552244 1.000 rs111392584 chr3:10075991 A/G cg02579736 chr3:10068473 FANCD2;CIDECP 1.05 14.06 0.61 1.71e-35 Alzheimer's disease; CRC cis rs9311474 0.539 rs12489828 chr3:52567014 G/T cg05573699 chr3:52720067 GNL3;PBRM1 -0.41 -6.23 -0.32 1.45e-9 Electroencephalogram traits; CRC cis rs2074585 0.517 rs11635361 chr15:91081791 G/T cg04176472 chr15:90893244 GABARAPL3 -0.38 -5.93 -0.31 7.5e-9 Basophil percentage of granulocytes;White blood cell count (basophil);Basophil percentage of white cells; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg09488452 chr16:14723959 PARN 0.47 6.56 0.34 2.14e-10 Response to antipsychotic treatment; CRC cis rs4925386 1.000 rs4925386 chr20:60921044 C/T cg15193198 chr20:60906057 LAMA5 -0.42 -7.1 -0.36 7.75e-12 Colorectal cancer;Colorectal cancer (SNP x SNP interaction); CRC cis rs9611565 0.592 rs4822046 chr22:41987543 G/A cg03806693 chr22:41940476 POLR3H -1.07 -12.49 -0.57 1.45e-29 Vitiligo; CRC cis rs2625529 0.526 rs11637611 chr15:72551712 C/T cg16672083 chr15:72433130 SENP8 0.45 6.81 0.35 4.63e-11 Red blood cell count; CRC cis rs7296418 0.961 rs1727307 chr12:123575742 A/G cg13010344 chr12:123464640 ARL6IP4 -0.36 -6.18 -0.32 1.93e-9 Platelet count; CRC cis rs11191205 0.644 rs10883664 chr10:103368208 C/T cg15320455 chr10:103880129 LDB1 0.51 5.62 0.3 4.17e-8 Intelligence (multi-trait analysis); CRC cis rs6951245 1.000 rs77760339 chr7:1083927 G/T cg22907277 chr7:1156413 C7orf50 0.72 7.47 0.38 7.14e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs11758351 1.000 rs16891397 chr6:26200256 C/T cg01420254 chr6:26195488 NA 0.82 8.57 0.43 4.19e-16 Gout;Renal underexcretion gout; CRC cis rs1552244 1.000 rs9811771 chr3:10133949 A/G cg10729496 chr3:10149963 C3orf24 0.49 6.65 0.34 1.22e-10 Alzheimer's disease; CRC cis rs6424115 0.830 rs3003333 chr1:24194014 A/T cg09473613 chr1:24152604 HMGCL -0.35 -5.88 -0.31 1.03e-8 Immature fraction of reticulocytes; CRC cis rs2180341 0.960 rs6900074 chr6:127685893 A/G cg27446573 chr6:127587934 RNF146 0.94 13.51 0.6 2.13e-33 Breast cancer; CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg15044954 chr7:89874365 C7orf63 -0.55 -7.01 -0.36 1.34e-11 Diisocyanate-induced asthma; CRC cis rs6743226 0.776 rs2166191 chr2:242152886 T/A cg10021735 chr2:242295487 FARP2 0.44 6.37 0.33 6.5e-10 Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI in non-smokers; CRC cis rs477692 0.875 rs7091540 chr10:131420276 C/T cg05714579 chr10:131428358 MGMT -0.59 -8.59 -0.43 3.52e-16 Response to temozolomide; CRC cis rs6963495 0.818 rs55983796 chr7:105170941 C/T cg13798780 chr7:105162888 PUS7 0.68 8.04 0.41 1.59e-14 Bipolar disorder (body mass index interaction); CRC cis rs2153535 0.601 rs9393030 chr6:8516489 C/G cg07606381 chr6:8435919 SLC35B3 0.68 11.13 0.52 1.2e-24 Motion sickness; CRC trans rs2921036 0.529 rs2979192 chr8:8338147 C/T cg08071915 chr8:12219732 FAM66A -0.35 -6.04 -0.32 4.25e-9 Neuroticism; CRC cis rs6582630 0.599 rs8175936 chr12:38426315 C/G cg13010199 chr12:38710504 ALG10B -0.4 -5.7 -0.3 2.63e-8 Drug-induced liver injury (flucloxacillin); CRC cis rs9818758 0.607 rs61729488 chr3:49067904 T/C cg00383909 chr3:49044727 WDR6 1.38 12.24 0.56 1.22e-28 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; CRC cis rs736801 0.740 rs12515180 chr5:131785684 C/T cg07395648 chr5:131743802 NA -0.39 -5.69 -0.3 2.75e-8 Breast cancer;Mosquito bite size; CRC cis rs2213920 0.679 rs7860135 chr9:118242257 G/A cg13918206 chr9:118159781 DEC1 0.61 5.64 0.3 3.6e-8 Docetaxel-induced peripheral neuropathy in metastatic castrate-resistant prostate cancer; CRC cis rs9837602 1.000 rs923471 chr3:99757853 C/T cg07805332 chr3:99536008 MIR548G;C3orf26 -0.53 -6.26 -0.33 1.19e-9 Breast cancer; CRC cis rs7621025 0.500 rs71630059 chr3:136581611 G/A cg15507776 chr3:136538369 TMEM22 -0.46 -6.58 -0.34 1.88e-10 C-reactive protein levels or HDL-cholesterol levels (pleiotropy);Body mass index; CRC cis rs56235845 0.964 rs11746443 chr5:176798306 G/A cg17261708 chr5:176794207 RGS14 0.63 9.61 0.47 1.92e-19 Hemoglobin concentration;Hematocrit; CRC cis rs1552244 0.572 rs58223482 chr3:10169746 G/C cg13047869 chr3:10149882 C3orf24 0.53 6.49 0.34 3.25e-10 Alzheimer's disease; CRC cis rs6866344 0.570 rs6896799 chr5:178147014 G/C cg10224037 chr5:178157518 ZNF354A 0.8 11.75 0.54 7.74e-27 Neutrophil percentage of white cells; CRC cis rs9911578 1.000 rs12453049 chr17:56611372 C/T cg05425664 chr17:57184151 TRIM37 0.51 8.17 0.41 6.81e-15 Intelligence (multi-trait analysis); CRC cis rs2806561 0.704 rs667330 chr1:23515257 A/G cg12483005 chr1:23474871 LUZP1 0.49 7.15 0.37 5.6e-12 Height; CRC cis rs2239547 0.522 rs4519686 chr3:52997871 C/T cg05573699 chr3:52720067 GNL3;PBRM1 -0.43 -5.7 -0.3 2.66e-8 Schizophrenia; CRC cis rs9303401 0.703 rs8072182 chr17:57211213 G/A cg02118635 chr17:56770003 RAD51C;TEX14 0.45 6.93 0.36 2.19e-11 Cognitive test performance; CRC cis rs9788721 0.836 rs17484524 chr15:78772676 A/G cg18825076 chr15:78729989 IREB2 -0.49 -7.17 -0.37 5e-12 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio;Emphysema imaging phenotypes;Emphysema distribution in smoking;Local histogram emphysema pattern;Post bronchodilator FEV1/FVC ratio in COPD; CRC cis rs7959452 0.535 rs1350166 chr12:69636314 G/T cg14784868 chr12:69753453 YEATS4 0.74 11.84 0.55 3.41e-27 Blood protein levels; CRC cis rs7762018 0.891 rs3749882 chr6:170151766 C/T cg19338460 chr6:170058176 WDR27 -0.7 -7.65 -0.39 2.25e-13 Thiazide-induced adverse metabolic effects in hypertensive patients; CRC trans rs7027930 0.524 rs16924559 chr9:608497 G/T cg27061366 chr19:13044373 FARSA 0.5 6.14 0.32 2.39e-9 Pulmonary function decline; CRC cis rs2243480 0.803 rs35268390 chr7:65416536 C/G cg18252515 chr7:66147081 NA -1.07 -12.49 -0.57 1.49e-29 Diabetic kidney disease; CRC cis rs67981189 0.529 rs8014273 chr14:71509830 A/G cg15910301 chr14:71632612 NA 0.31 6.12 0.32 2.69e-9 Schizophrenia; CRC cis rs6445967 1.000 rs2292674 chr3:58302404 A/T cg23715586 chr3:58305044 RPP14 0.35 5.82 0.31 1.37e-8 Platelet count; CRC trans rs6951245 1.000 rs79422648 chr7:1080241 T/C cg13565492 chr6:43139072 SRF -0.71 -7.27 -0.37 2.61e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC trans rs12310399 0.635 rs10859844 chr12:95573040 G/T cg16511708 chr18:23671264 SS18 0.44 6.31 0.33 8.83e-10 Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel + carboplatin); CRC cis rs62458065 1.000 rs79538247 chr7:32467792 A/G cg20159608 chr7:32802032 NA -0.51 -6.38 -0.33 6.01e-10 Metabolite levels (HVA/MHPG ratio); CRC cis rs7772486 0.681 rs9390343 chr6:146010527 A/T cg23711669 chr6:146136114 FBXO30 -0.64 -10.37 -0.5 5.37e-22 Lobe attachment (rater-scored or self-reported); CRC cis rs992157 0.835 rs2292555 chr2:219146882 G/C cg13835894 chr2:219148914 PNKD;TMBIM1 -0.35 -6.57 -0.34 2e-10 Colorectal cancer; CRC cis rs896854 0.684 rs10099059 chr8:95986972 G/C cg13393036 chr8:95962371 TP53INP1 -0.51 -8.76 -0.43 1.05e-16 Type 2 diabetes; CRC cis rs7119 0.604 rs939488 chr15:77867780 T/C cg27398640 chr15:77910606 LINGO1 0.45 7.72 0.39 1.45e-13 Type 2 diabetes; CRC trans rs7976838 0.908 rs12812257 chr12:60137094 C/G cg16974014 chr22:22007515 MIR130B 0.49 6.0 0.31 5.21e-9 Response to zileuton treatment in asthma (FEV1 change interaction); CRC trans rs1814175 0.645 rs1851869 chr11:49960552 T/C cg15704280 chr7:45808275 SEPT13 -0.94 -16.88 -0.68 1.75e-46 Height; CRC cis rs7937682 0.575 rs7950926 chr11:111776437 G/C cg19812747 chr11:111475976 SIK2 0.47 7.36 0.38 1.48e-12 Primary sclerosing cholangitis; CRC cis rs875971 1.000 rs6460296 chr7:65895139 C/T cg11764359 chr7:65958608 NA 0.62 9.91 0.48 1.96e-20 Aortic root size; CRC cis rs55702914 0.628 rs12151767 chr2:198274929 C/T cg10820045 chr2:198174542 NA 0.32 5.66 0.3 3.38e-8 Major depression and alcohol dependence; CRC cis rs10504229 0.683 rs949856 chr8:58144496 G/A cg24829409 chr8:58192753 C8orf71 -0.54 -8.0 -0.4 2.13e-14 Developmental language disorder (linguistic errors); CRC cis rs9908102 0.740 rs7211501 chr17:12917479 A/G cg26162695 chr17:12921313 ELAC2 0.43 5.66 0.3 3.27e-8 Schizophrenia; CRC cis rs6424115 1.000 rs12116511 chr1:24162662 A/G cg09473613 chr1:24152604 HMGCL -0.36 -6.1 -0.32 2.95e-9 Immature fraction of reticulocytes; CRC cis rs4132509 0.843 rs6671475 chr1:243789342 A/G cg21452805 chr1:244014465 NA 0.5 6.93 0.36 2.26e-11 RR interval (heart rate); CRC cis rs3091242 0.933 rs11249251 chr1:25770188 C/G cg20684491 chr1:25596433 NA 0.43 7.45 0.38 8.23e-13 Erythrocyte sedimentation rate; CRC cis rs6570726 0.791 rs9322029 chr6:145906683 A/G cg05347473 chr6:146136440 FBXO30 0.38 5.8 0.3 1.54e-8 Lobe attachment (rater-scored or self-reported); CRC cis rs3741798 1.000 rs61922047 chr12:12496471 C/A cg08615371 chr12:12503544 MANSC1 1.02 9.12 0.45 7.53e-18 Cerebrospinal fluid biomarker levels; CRC cis rs10504229 0.610 rs7011877 chr8:58147181 C/T cg02725872 chr8:58115012 NA -0.59 -11.12 -0.52 1.3e-24 Developmental language disorder (linguistic errors); CRC cis rs11227306 0.812 rs11227310 chr11:65584733 A/T cg26695010 chr11:65641043 EFEMP2 -0.48 -6.43 -0.33 4.38e-10 DNA methylation (variation); CRC cis rs728616 0.867 rs34870056 chr10:81948055 G/A cg05935833 chr10:81318306 SFTPA2 -0.7 -7.67 -0.39 1.93e-13 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs7927592 0.731 rs488381 chr11:68291693 G/A cg01657329 chr11:68192670 LRP5 0.55 9.15 0.45 6.15e-18 Total body bone mineral density; CRC cis rs938554 0.779 rs13106991 chr4:9959011 G/A cg00071950 chr4:10020882 SLC2A9 -0.44 -5.83 -0.31 1.3e-8 Blood metabolite levels; CRC cis rs9322193 0.884 rs1108889 chr6:150166569 A/G cg05861140 chr6:150128134 PCMT1 -0.41 -6.37 -0.33 6.41e-10 Lung cancer; CRC cis rs10504229 0.815 rs72650879 chr8:58164648 A/G cg05313129 chr8:58192883 C8orf71 -0.5 -6.34 -0.33 7.58e-10 Developmental language disorder (linguistic errors); CRC cis rs5769765 0.908 rs138867 chr22:50207703 A/G cg04121214 chr22:50244548 NA -0.39 -5.69 -0.3 2.81e-8 Schizophrenia; CRC cis rs13108904 0.539 rs13135102 chr4:1330983 A/C cg21620606 chr4:1342894 KIAA1530 0.51 8.18 0.41 6.17e-15 Obesity-related traits; CRC cis rs57221529 0.766 rs56216231 chr5:581193 G/A cg16447950 chr5:562315 NA -0.83 -10.78 -0.51 2.14e-23 Lung disease severity in cystic fibrosis; CRC cis rs4713118 0.784 rs9468219 chr6:27731755 C/A cg15845792 chr6:28175446 NA 0.65 8.49 0.42 7.04e-16 Parkinson's disease; CRC cis rs10927875 0.722 rs6696912 chr1:16338474 T/C cg24140574 chr1:16342155 HSPB7 0.43 5.74 0.3 2.11e-8 Dilated cardiomyopathy; CRC cis rs2836974 0.897 rs13049280 chr21:40594656 C/G cg17971929 chr21:40555470 PSMG1 0.74 10.02 0.48 8.29e-21 Cognitive function; CRC cis rs10791323 0.628 rs1893850 chr11:133705356 T/C cg15485101 chr11:133734466 NA 0.4 6.91 0.36 2.45e-11 Childhood ear infection; CRC cis rs225245 0.687 rs321614 chr17:33881734 A/G cg05299278 chr17:33885742 SLFN14 0.4 6.38 0.33 5.86e-10 Reticulocyte count;Reticulocyte fraction of red cells;High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells; CRC cis rs7618915 0.571 rs34954168 chr3:52612159 C/T cg18404041 chr3:52824283 ITIH1 -0.42 -8.75 -0.43 1.13e-16 Bipolar disorder; CRC trans rs2727020 0.688 rs4929894 chr11:49196333 G/C cg21153622 chr11:89784906 NA -0.44 -7.17 -0.37 4.95e-12 Coronary artery disease; CRC cis rs8177253 1.000 rs8177271 chr3:133482230 G/A cg11941060 chr3:133502564 NA -0.57 -9.82 -0.48 4.01e-20 Iron status biomarkers; CRC cis rs910316 0.503 rs12894709 chr14:75441734 G/A cg08847533 chr14:75593920 NEK9 0.75 12.35 0.56 4.72e-29 Height; CRC cis rs924607 1.000 rs2455331 chr5:643593 T/C cg04221910 chr5:616842 CEP72 0.41 6.7 0.35 9.26e-11 Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia; CRC cis rs12497850 0.897 rs6795025 chr3:49081247 T/C cg07636037 chr3:49044803 WDR6 1.04 18.23 0.71 8.11e-52 Parkinson's disease; CRC cis rs6502050 0.805 rs9898326 chr17:80119582 C/T cg02741985 chr17:80059408 CCDC57 0.43 7.15 0.37 5.59e-12 Life satisfaction; CRC cis rs4073582 0.516 rs1151539 chr11:66031660 C/T cg16950941 chr11:66035639 RAB1B 0.71 12.12 0.56 3.47e-28 Gout; CRC trans rs1997103 0.954 rs6593222 chr7:55372932 A/C cg20935933 chr6:143382018 AIG1 0.52 6.78 0.35 5.71e-11 QRS interval (sulfonylurea treatment interaction); CRC cis rs13191362 0.935 rs34540135 chr6:162934351 A/G cg21926612 chr6:163149169 PACRG;PARK2 0.79 9.53 0.46 3.7e-19 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs12893668 0.572 rs4900590 chr14:104146421 C/T cg24130564 chr14:104152367 KLC1 -0.42 -5.63 -0.3 3.9e-8 Reticulocyte count; CRC cis rs4604732 0.588 rs6677477 chr1:247629411 C/T cg12758973 chr1:247694275 LOC148824;OR2C3 0.38 5.69 0.3 2.74e-8 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CRC cis rs7727544 0.660 rs272886 chr5:131665840 T/C cg24060327 chr5:131705240 SLC22A5 -0.35 -5.71 -0.3 2.46e-8 Blood metabolite levels; CRC cis rs4713118 0.869 rs4713121 chr6:27722064 T/C cg12273811 chr6:28175739 NA 0.59 7.51 0.38 5.73e-13 Parkinson's disease; CRC cis rs11758351 1.000 rs75921373 chr6:26191843 C/T cg01420254 chr6:26195488 NA 0.81 8.55 0.43 4.7e-16 Gout;Renal underexcretion gout; CRC cis rs6500602 0.627 rs2270363 chr16:4526292 A/G cg08645402 chr16:4508243 NA 0.56 8.24 0.41 4.24e-15 Schizophrenia; CRC trans rs61931739 0.500 rs3922568 chr12:34560107 A/C cg13010199 chr12:38710504 ALG10B 0.46 6.57 0.34 2.02e-10 Morning vs. evening chronotype; CRC cis rs924607 1.000 rs924607 chr5:610093 C/T cg24163568 chr5:669837 TPPP -0.43 -6.92 -0.36 2.36e-11 Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia; CRC cis rs317689 0.684 rs315125 chr12:69758884 C/T cg20891283 chr12:69753455 YEATS4 0.67 8.5 0.42 6.85e-16 Response to diuretic therapy; CRC trans rs10506458 1.000 rs73128794 chr12:63445313 C/T cg03429785 chr15:59498649 MYO1E;LDHAL6B -1.33 -19.27 -0.73 6.32e-56 Hemostatic factors and hematological phenotypes; CRC cis rs6502050 0.835 rs10163496 chr17:80110867 G/A cg22110888 chr17:80059540 CCDC57 0.4 6.44 0.33 4.17e-10 Life satisfaction; CRC cis rs1552244 0.572 rs7645667 chr3:10157337 C/A cg10729496 chr3:10149963 C3orf24 0.54 6.16 0.32 2.13e-9 Alzheimer's disease; CRC cis rs861020 0.883 rs680331 chr1:209959872 G/A cg05527609 chr1:210001259 C1orf107 0.85 10.84 0.51 1.29e-23 Orofacial clefts; CRC cis rs748404 0.690 rs2244981 chr15:43752751 T/C cg02155558 chr15:43621948 ADAL;LCMT2 0.52 7.56 0.38 3.98e-13 Lung cancer; CRC cis rs1799949 1.000 rs33945274 chr17:41280073 G/A cg19454999 chr17:41278357 BRCA1;NBR2 0.55 8.63 0.43 2.68e-16 Menopause (age at onset); CRC cis rs4689388 0.853 rs13108780 chr4:6294630 A/G cg25554036 chr4:6271136 WFS1 0.53 8.7 0.43 1.59e-16 Type 2 diabetes and other traits;Type 2 diabetes; CRC cis rs7618501 1.000 rs7618501 chr3:49772647 A/G cg24308560 chr3:49941425 MST1R 0.45 7.01 0.36 1.33e-11 Intelligence (multi-trait analysis); CRC cis rs3617 0.539 rs11130331 chr3:52956918 G/A cg07507251 chr3:52567010 NT5DC2 -0.38 -5.91 -0.31 8.43e-9 Red blood cell count;Autism spectrum disorder or schizophrenia; CRC cis rs8103278 1.000 rs36091860 chr19:46312880 G/A cg14061069 chr19:46274453 DMPK -0.55 -8.39 -0.42 1.41e-15 Coronary artery disease; CRC cis rs6901250 0.587 rs339357 chr6:117198291 G/C cg12892004 chr6:117198278 RFX6 -0.44 -6.85 -0.35 3.65e-11 C-reactive protein levels; CRC cis rs2882667 0.898 rs3925110 chr5:138371365 C/G cg09476006 chr5:138032270 NA 0.44 7.34 0.38 1.64e-12 Age-related hearing impairment (SNP x SNP interaction); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg22166703 chr1:33722127 ZNF362 0.4 6.51 0.34 2.85e-10 Liver disease severity in Alagille syndrome; CRC cis rs7618915 0.547 rs2878726 chr3:52748271 C/G cg15147215 chr3:52552868 STAB1 -0.61 -10.04 -0.48 7.46e-21 Bipolar disorder; CRC cis rs1801251 1.000 rs4973055 chr2:233720283 G/T cg25237894 chr2:233734115 C2orf82 -0.48 -7.72 -0.39 1.37e-13 Coronary artery disease; CRC cis rs11758351 0.925 rs10452600 chr6:26192502 C/A cg01420254 chr6:26195488 NA 0.83 8.68 0.43 1.82e-16 Gout;Renal underexcretion gout; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg04940776 chr16:29874983 LOC440356;CDIPT 0.44 6.4 0.33 5.3e-10 Intelligence (multi-trait analysis); CRC trans rs3942852 0.606 rs10734561 chr11:48097480 C/T cg03929089 chr4:120376271 NA -0.59 -7.56 -0.38 4.04e-13 Acute lymphoblastic leukemia (childhood); CRC cis rs4713118 0.869 rs10214440 chr6:27702440 A/C cg25164649 chr6:28176230 NA 0.6 8.47 0.42 8.12e-16 Parkinson's disease; CRC cis rs7666738 0.830 rs11731478 chr4:99001686 A/G cg17366294 chr4:99064904 C4orf37 0.44 7.39 0.38 1.19e-12 Colonoscopy-negative controls vs population controls; CRC cis rs7927592 0.913 rs7106339 chr11:68240241 C/T cg16797656 chr11:68205561 LRP5 0.39 6.12 0.32 2.63e-9 Total body bone mineral density; CRC cis rs1816752 0.905 rs7339140 chr13:25011902 A/G cg02811702 chr13:24901961 NA 0.47 6.56 0.34 2.09e-10 Obesity-related traits; CRC cis rs68170813 0.559 rs7809508 chr7:107004119 T/C cg02696742 chr7:106810147 HBP1 -0.56 -6.09 -0.32 3.16e-9 Coronary artery disease; CRC cis rs10504229 0.775 rs10504228 chr8:58162053 T/G cg08219700 chr8:58056026 NA 0.46 5.63 0.3 3.93e-8 Developmental language disorder (linguistic errors); CRC cis rs738321 0.757 rs4821748 chr22:38541936 G/A cg25457927 chr22:38595422 NA -0.3 -5.98 -0.31 5.92e-9 Breast cancer; CRC cis rs611744 0.647 rs7015513 chr8:109262570 A/C cg21045802 chr8:109455806 TTC35 0.41 6.52 0.34 2.68e-10 Dupuytren's disease; CRC trans rs7618501 0.633 rs6446189 chr3:50008566 A/G cg21659725 chr3:3221576 CRBN 0.61 9.59 0.47 2.31e-19 Intelligence (multi-trait analysis); CRC cis rs9372498 0.572 rs10484289 chr6:118827836 T/C cg24463073 chr6:118973353 C6orf204 0.52 7.14 0.37 6.17e-12 Diastolic blood pressure; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg16333535 chr22:24093440 ZNF70 0.44 6.2 0.32 1.71e-9 Response to antipsychotic treatment; CRC cis rs79387448 0.745 rs7572284 chr2:103119423 C/A cg09003973 chr2:102972529 NA 0.69 7.61 0.39 2.85e-13 Gut microbiota (bacterial taxa); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg12343791 chr22:39240109 NPTXR 0.38 6.49 0.34 3.11e-10 Liver disease severity in Alagille syndrome; CRC cis rs1707322 0.648 rs4439382 chr1:46150805 C/T cg06784218 chr1:46089804 CCDC17 0.65 12.22 0.56 1.4e-28 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC trans rs1814175 0.647 rs61306292 chr11:49856040 G/C cg21153622 chr11:89784906 NA -0.39 -6.1 -0.32 3e-9 Height; CRC cis rs7833986 0.501 rs72653967 chr8:56999432 G/A cg23139584 chr8:56987506 RPS20;SNORD54 0.91 12.4 0.56 3.1e-29 Height; CRC cis rs12497850 0.931 rs7623023 chr3:48914238 G/A cg07636037 chr3:49044803 WDR6 1.03 18.4 0.71 1.66e-52 Parkinson's disease; CRC trans rs9988642 0.737 rs41494046 chr1:67722919 C/G cg08333703 chr19:35225315 ZNF181 -0.45 -5.96 -0.31 6.51e-9 Psoriasis vulgaris;Crohn's disease; CRC cis rs11724804 0.532 rs7657611 chr4:880558 G/C cg20916646 chr4:852691 GAK 0.6 8.59 0.43 3.65e-16 Primary biliary cholangitis;Limited cutaneous systemic scleroderma; CRC trans rs7800418 0.723 rs4555996 chr7:26589827 A/G cg14387656 chr2:233470847 EFHD1 0.47 6.51 0.34 2.79e-10 Cognitive function; CRC cis rs4332037 0.539 rs11762545 chr7:2060775 C/T cg21155852 chr7:2048760 MAD1L1 -0.5 -6.69 -0.35 9.34e-11 Bipolar disorder; CRC cis rs5750830 0.649 rs5757663 chr22:39821319 T/C cg24399712 chr22:39784796 NA -0.47 -8.96 -0.44 2.52e-17 Intelligence (multi-trait analysis); CRC cis rs921968 0.591 rs13421421 chr2:219519286 A/G cg02176678 chr2:219576539 TTLL4 0.51 8.53 0.43 5.48e-16 Mean corpuscular hemoglobin concentration; CRC cis rs910316 1.000 rs12889472 chr14:75543979 A/G cg11812906 chr14:75593930 NEK9 0.64 10.07 0.49 5.92e-21 Height; CRC cis rs1348850 1.000 rs3927978 chr2:178443854 A/G cg22681709 chr2:178499509 PDE11A 0.37 6.92 0.36 2.37e-11 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs1218582 0.774 rs4845681 chr1:154868055 G/T cg16680214 chr1:154839983 KCNN3 -0.49 -9.86 -0.48 2.96e-20 Prostate cancer; CRC cis rs6952808 0.609 rs12699453 chr7:1953056 C/T cg14004847 chr7:1930337 MAD1L1 -0.41 -5.99 -0.31 5.59e-9 Bipolar disorder and schizophrenia; CRC cis rs9926296 0.568 rs1230 chr16:89804855 A/G cg04287289 chr16:89883240 FANCA -0.82 -14.42 -0.62 6.89e-37 Vitiligo; CRC cis rs2032447 0.839 rs9356995 chr6:25996673 G/A cg18357526 chr6:26021779 HIST1H4A 0.74 11.41 0.53 1.24e-25 Intelligence (multi-trait analysis); CRC cis rs56114371 0.530 rs169262 chr6:27770890 C/T cg19041857 chr6:27730383 NA -0.47 -6.05 -0.32 3.86e-9 Breast cancer; CRC cis rs7224737 1.000 rs1122326 chr17:40274873 A/C cg02228675 chr17:40259724 DHX58 -0.45 -5.97 -0.31 6.29e-9 Fibrinogen levels; CRC trans rs7615952 0.736 rs9862893 chr3:125686974 A/G cg07211511 chr3:129823064 LOC729375 -0.99 -12.67 -0.57 2.99e-30 Blood pressure (smoking interaction); CRC cis rs2075371 0.933 rs431306 chr7:133955974 A/T cg20476274 chr7:133979776 SLC35B4 0.76 13.49 0.6 2.57e-33 Mean platelet volume; CRC cis rs7927771 0.832 rs11601603 chr11:47401171 A/C cg05585544 chr11:47624801 NA -0.5 -8.98 -0.44 2.06e-17 Subjective well-being; CRC cis rs6479527 0.875 rs10821284 chr9:96776124 T/G cg14459158 chr9:96720562 NA 0.39 6.97 0.36 1.69e-11 Esophageal adenocarcinoma; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg05630523 chr19:12886518 HOOK2 0.48 6.59 0.34 1.75e-10 Response to antipsychotic treatment; CRC cis rs427394 0.659 rs274695 chr5:6732252 G/C cg15145174 chr5:6755386 POLS -0.46 -6.8 -0.35 5e-11 Menopause (age at onset); CRC cis rs12477438 0.798 rs2123686 chr2:99690135 G/A cg26064155 chr2:99771622 LIPT1;TSGA10 -0.63 -8.55 -0.43 4.61e-16 Chronic sinus infection; CRC cis rs3741404 0.560 rs17699798 chr11:63898806 C/G cg05555928 chr11:63887634 MACROD1 0.38 6.22 0.32 1.47e-9 Platelet count; CRC cis rs3749237 0.576 rs4241406 chr3:49600426 C/T cg07636037 chr3:49044803 WDR6 0.55 8.01 0.4 1.95e-14 Resting heart rate; CRC cis rs7113874 0.550 rs11042002 chr11:8616646 T/C cg02811074 chr11:8615871 STK33 0.36 6.15 0.32 2.22e-9 Body mass index in physically active individuals;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs7312933 0.934 rs11181289 chr12:42402342 C/T cg11827402 chr12:42719852 PPHLN1;ZCRB1 0.6 7.54 0.38 4.55e-13 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CRC cis rs6951245 0.638 rs74976697 chr7:1160505 C/T cg18402987 chr7:1209562 NA 0.66 7.65 0.39 2.26e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs1005277 0.579 rs2103938 chr10:38493998 T/G cg00409905 chr10:38381863 ZNF37A -0.62 -10.3 -0.49 9.48e-22 Extrinsic epigenetic age acceleration; CRC cis rs919433 0.963 rs12693815 chr2:198168403 T/C cg10820045 chr2:198174542 NA -0.55 -9.55 -0.47 3.11e-19 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg25574672 chr5:133562092 PPP2CA 0.4 6.43 0.33 4.43e-10 Liver disease severity in Alagille syndrome; CRC cis rs73206853 0.841 rs55885183 chr12:110877682 A/G cg12870014 chr12:110450643 ANKRD13A 0.75 8.18 0.41 6.45e-15 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC cis rs2404602 0.647 rs11634266 chr15:77093461 A/G cg03037974 chr15:76606532 NA -0.54 -8.17 -0.41 6.88e-15 Blood metabolite levels; CRC cis rs904251 0.772 rs2252920 chr6:37418327 A/G cg25019722 chr6:37503610 NA -0.42 -6.87 -0.35 3.23e-11 Cognitive performance; CRC cis rs7542091 0.704 rs7537294 chr1:210043777 A/G cg22029157 chr1:209979665 IRF6 0.47 7.4 0.38 1.11e-12 Monobrow; CRC cis rs3087591 0.708 rs12940802 chr17:29643564 C/A cg24425628 chr17:29625626 OMG;NF1 0.71 13.15 0.59 4.98e-32 Hip circumference; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg26714410 chr13:45150072 TSC22D1 0.47 6.45 0.34 3.93e-10 Thyroid stimulating hormone; CRC cis rs9549367 0.713 rs3024743 chr13:113821430 C/T cg24300038 chr13:113819356 PROZ -0.48 -6.09 -0.32 3.19e-9 Platelet distribution width; CRC cis rs7666738 0.830 rs3907021 chr4:99038668 C/T cg05340658 chr4:99064831 C4orf37 0.6 9.45 0.46 6.36e-19 Colonoscopy-negative controls vs population controls; CRC cis rs10883723 0.810 rs913025 chr10:104276043 C/T cg04362960 chr10:104952993 NT5C2 -0.4 -5.6 -0.3 4.46e-8 Allergic disease (asthma, hay fever or eczema); CRC cis rs1577917 1.000 rs955227 chr6:86651032 C/A cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.58 -7.18 -0.37 4.56e-12 Response to antipsychotic treatment; CRC trans rs6951245 1.000 rs74887741 chr7:1110658 G/T cg13565492 chr6:43139072 SRF -0.72 -7.39 -0.38 1.21e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs10028773 0.515 rs9994488 chr4:120587781 C/T cg24375607 chr4:120327624 NA 0.48 7.55 0.38 4.25e-13 Educational attainment; CRC cis rs17711722 0.523 rs365896 chr7:65510697 A/G cg02869306 chr7:64672164 INTS4L1 0.45 7.82 0.4 7.21e-14 Calcium levels; CRC cis rs208520 0.690 rs1233103 chr6:66855943 T/G cg07460842 chr6:66804631 NA -1.06 -14.8 -0.63 2.51e-38 Exhaled nitric oxide output; CRC trans rs853679 0.546 rs200981 chr6:27833174 A/G cg06606381 chr12:133084897 FBRSL1 -0.74 -6.43 -0.33 4.4e-10 Depression; CRC cis rs9837602 0.938 rs34922392 chr3:99794730 G/T cg07805332 chr3:99536008 MIR548G;C3orf26 -0.5 -6.65 -0.34 1.2e-10 Breast cancer; CRC cis rs1799949 0.930 rs2298861 chr17:41176831 G/A cg23758822 chr17:41437982 NA 0.8 13.22 0.59 2.77e-32 Menopause (age at onset); CRC cis rs4665809 1.000 rs6546736 chr2:26293878 C/T cg04944784 chr2:26401820 FAM59B 0.61 7.86 0.4 5.69e-14 Gut microbiome composition (summer); CRC cis rs6500395 0.651 rs28432694 chr16:48666310 A/T cg04672837 chr16:48644449 N4BP1 0.4 5.86 0.31 1.14e-8 Response to tocilizumab in rheumatoid arthritis; CRC cis rs9926296 0.512 rs11076626 chr16:89865103 T/A cg27121462 chr16:89883253 FANCA 0.6 9.81 0.48 4.28e-20 Vitiligo; CRC cis rs11690935 0.959 rs2674484 chr2:172574612 G/A cg13550731 chr2:172543902 DYNC1I2 -1.1 -19.12 -0.73 2.45e-55 Schizophrenia; CRC cis rs798554 0.679 rs2527677 chr7:2882621 A/G cg19717773 chr7:2847554 GNA12 -0.44 -6.16 -0.32 2.14e-9 Height; CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg26942392 chr20:5591638 RP5-1022P6.2 0.38 5.97 0.31 6.11e-9 Obesity-related traits; CRC cis rs9287719 0.967 rs6721739 chr2:10751246 G/T cg00105475 chr2:10696890 NA -0.44 -6.97 -0.36 1.77e-11 Prostate cancer; CRC cis rs3785574 0.962 rs57553639 chr17:61848499 C/T cg06601766 chr17:61851465 DDX42;CCDC47 0.6 8.54 0.43 5.06e-16 Height; CRC cis rs7615952 0.576 rs2276727 chr3:125826243 C/T cg05084668 chr3:125655381 ALG1L -0.4 -5.7 -0.3 2.72e-8 Blood pressure (smoking interaction); CRC cis rs35883536 1.000 rs4907921 chr1:101128249 C/T cg14515779 chr1:101123966 NA -0.44 -8.42 -0.42 1.14e-15 Monocyte count; CRC trans rs2243480 1.000 rs4718316 chr7:65648731 A/G cg10756647 chr7:56101905 PSPH -0.76 -7.87 -0.4 5.31e-14 Diabetic kidney disease; CRC cis rs67311347 0.544 rs1454492 chr3:40352884 C/T cg09455208 chr3:40491958 NA 0.31 6.15 0.32 2.3e-9 Renal cell carcinoma; CRC cis rs853679 0.517 rs9368555 chr6:28108967 T/C cg12172441 chr6:28176163 NA 0.64 7.53 0.38 5.03e-13 Depression; CRC cis rs9926296 0.682 rs645019 chr16:89716883 C/T cg01097406 chr16:89675127 NA 0.5 9.1 0.45 9.1e-18 Vitiligo; CRC cis rs78761021 0.867 rs17681684 chr17:9792768 A/G cg26853458 chr17:9805074 RCVRN -0.39 -7.26 -0.37 2.73e-12 Type 2 diabetes; CRC cis rs10504229 0.683 rs17194792 chr8:58107195 A/C cg20607798 chr8:58055168 NA 0.58 6.56 0.34 2.06e-10 Developmental language disorder (linguistic errors); CRC cis rs11628318 0.614 rs62007936 chr14:103198740 G/A cg12046867 chr14:103022105 NA 0.76 8.56 0.43 4.35e-16 Platelet count; CRC cis rs2239547 0.607 rs9836178 chr3:52925403 T/C cg11645453 chr3:52864694 ITIH4 -0.51 -8.75 -0.43 1.1e-16 Schizophrenia; CRC cis rs6951245 0.554 rs10246354 chr7:1132456 C/T cg03188948 chr7:1209495 NA 0.5 5.84 0.31 1.22e-8 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs4076764 1.000 rs4469696 chr1:163424565 C/T cg06092702 chr1:163392909 NA -0.57 -8.92 -0.44 3.21e-17 Motion sickness; CRC cis rs7789940 1.000 rs758944 chr7:75953297 G/T cg10167463 chr7:75959203 YWHAG -0.74 -10.8 -0.51 1.76e-23 Multiple sclerosis; CRC cis rs60871478 1.000 rs4719314 chr7:822523 A/G cg04727924 chr7:799746 HEATR2 -0.42 -6.13 -0.32 2.58e-9 Cerebrospinal P-tau181p levels; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg02935305 chr6:35995251 MAPK14 0.43 6.1 0.32 2.92e-9 Response to antipsychotic treatment; CRC cis rs1018836 0.798 rs4735295 chr8:91671608 C/A cg16814680 chr8:91681699 NA -0.92 -16.06 -0.66 2.83e-43 Ejection fraction in Tripanosoma cruzi seropositivity; CRC trans rs916888 0.821 rs199505 chr17:44859410 A/G cg10053473 chr17:62856997 LRRC37A3 0.71 8.39 0.42 1.42e-15 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs2067615 0.560 rs12298717 chr12:107099883 C/T cg13491945 chr12:107078410 RFX4 -0.35 -6.03 -0.32 4.37e-9 Heart rate; CRC trans rs208520 1.000 rs208529 chr6:66957549 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.88 -10.95 -0.52 5.22e-24 Exhaled nitric oxide output; CRC cis rs35110281 0.633 rs2329593 chr21:45121987 T/C cg04455712 chr21:45112962 RRP1B 0.41 7.82 0.4 7.1e-14 Mean corpuscular volume; CRC cis rs9443645 0.869 rs9343848 chr6:79621101 C/T cg05283184 chr6:79620031 NA -0.57 -9.15 -0.45 6.22e-18 Intelligence (multi-trait analysis); CRC cis rs9902453 1.000 rs6505158 chr17:28403348 A/G cg26525008 chr17:28256777 EFCAB5;SSH2 -0.59 -8.96 -0.44 2.46e-17 Coffee consumption (cups per day); CRC cis rs7493 1.000 rs17876124 chr7:95045258 C/G cg01874867 chr7:94954059 PON1 -0.48 -6.19 -0.32 1.81e-9 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs9443189 0.901 rs2038624 chr6:76560707 T/C cg01950844 chr6:76311363 SENP6 -0.62 -7.41 -0.38 1.04e-12 Prostate cancer; CRC cis rs9818758 0.505 rs67286839 chr3:49265744 C/T cg07636037 chr3:49044803 WDR6 -0.71 -6.01 -0.31 4.86e-9 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; CRC cis rs7845219 0.544 rs7001535 chr8:95921090 C/G cg16049864 chr8:95962084 TP53INP1 -0.44 -6.76 -0.35 6.15e-11 Type 2 diabetes; CRC cis rs3733585 0.699 rs4621431 chr4:9947590 C/T cg11266682 chr4:10021025 SLC2A9 -0.48 -9.38 -0.46 1.15e-18 Cleft plate (environmental tobacco smoke interaction); CRC cis rs7113874 0.550 rs2044464 chr11:8559695 G/A cg02811074 chr11:8615871 STK33 -0.36 -6.09 -0.32 3.13e-9 Body mass index in physically active individuals;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs12148488 0.966 rs1867149 chr15:75339993 C/T cg09165964 chr15:75287851 SCAMP5 -0.49 -7.38 -0.38 1.29e-12 Caffeine consumption; CRC cis rs6714710 0.663 rs71429376 chr2:98534412 T/C cg26665480 chr2:98280029 ACTR1B 0.5 6.94 0.36 2.14e-11 Posterior cortical atrophy and Alzheimer's disease; CRC cis rs56146971 0.763 rs34854034 chr14:91870677 A/G cg16433844 chr14:91963127 SMEK1 -0.6 -6.35 -0.33 7.26e-10 Alzheimer disease and age of onset; CRC cis rs9322193 0.847 rs56103941 chr6:150137231 A/G cg04369109 chr6:150039330 LATS1 -0.45 -5.85 -0.31 1.22e-8 Lung cancer; CRC cis rs6921919 0.609 rs1005127 chr6:28367658 G/A cg21251018 chr6:28226885 NKAPL 0.39 5.81 0.31 1.48e-8 Autism spectrum disorder or schizophrenia; CRC cis rs1873147 0.731 rs12902152 chr15:63313968 T/C cg12160578 chr15:63334699 TPM1 -0.43 -5.86 -0.31 1.11e-8 Orofacial clefts; CRC cis rs2274273 0.686 rs17253695 chr14:55574610 A/T cg10130446 chr14:55658398 DLGAP5 0.43 5.8 0.3 1.57e-8 Protein biomarker; CRC cis rs1018836 0.851 rs10808620 chr8:91622940 T/C cg16814680 chr8:91681699 NA -0.77 -12.29 -0.56 7.82e-29 Ejection fraction in Tripanosoma cruzi seropositivity; CRC cis rs910316 0.737 rs108622 chr14:75481908 A/G cg03030879 chr14:75389066 RPS6KL1 0.43 6.54 0.34 2.35e-10 Height; CRC trans rs9329221 0.617 rs483916 chr8:9793601 A/C cg16141378 chr3:129829833 LOC729375 0.49 7.76 0.39 1.12e-13 Neuroticism; CRC cis rs2303759 0.666 rs66967196 chr19:49808894 G/A cg22307029 chr19:49891270 CCDC155 0.68 8.87 0.44 4.69e-17 Multiple sclerosis; CRC cis rs2243480 1.000 rs34703416 chr7:65300642 A/G cg12463550 chr7:65579703 CRCP 0.67 6.15 0.32 2.2e-9 Diabetic kidney disease; CRC cis rs9325144 0.560 rs61929893 chr12:38653366 G/A cg26384229 chr12:38710491 ALG10B -0.56 -8.38 -0.42 1.54e-15 Morning vs. evening chronotype; CRC cis rs11792861 0.591 rs4978763 chr9:111728067 C/T cg14432460 chr9:111696404 IKBKAP;C9orf6 0.51 7.16 0.37 5.26e-12 Menarche (age at onset); CRC cis rs1799949 1.000 rs12944597 chr17:41187684 A/C cg05368731 chr17:41323189 NBR1 0.67 9.58 0.47 2.42e-19 Menopause (age at onset); CRC cis rs10504229 0.683 rs72650839 chr8:58130029 C/T cg22535103 chr8:58192502 C8orf71 -0.7 -9.34 -0.46 1.47e-18 Developmental language disorder (linguistic errors); CRC trans rs2303319 0.504 rs62187609 chr2:162431500 C/T cg09481857 chr22:21368659 P2RX6;MGC16703 -0.66 -6.16 -0.32 2.08e-9 Cognitive function; CRC trans rs8002861 0.664 rs1808097 chr13:44424766 A/G cg17145862 chr1:211918768 LPGAT1 0.57 9.92 0.48 1.87e-20 Leprosy; CRC cis rs6582630 0.519 rs11495700 chr12:38288240 A/G cg26384229 chr12:38710491 ALG10B 0.69 9.36 0.46 1.29e-18 Drug-induced liver injury (flucloxacillin); CRC cis rs10991814 0.841 rs79219699 chr9:94028898 C/T cg14446406 chr9:93919335 NA 0.55 5.95 0.31 7.05e-9 Neutrophil percentage of granulocytes; CRC cis rs7249142 0.549 rs2283623 chr19:19283027 G/C cg12558012 chr19:19281197 LOC729991-MEF2B;MEF2B 0.55 8.52 0.43 5.89e-16 IgG glycosylation; CRC trans rs9467711 0.606 rs9379900 chr6:26603811 A/C cg06606381 chr12:133084897 FBRSL1 -0.85 -6.44 -0.33 4.18e-10 Autism spectrum disorder or schizophrenia; CRC cis rs6694672 0.764 rs668590 chr1:197220598 A/T cg13682187 chr1:196946512 CFHR5 0.49 7.01 0.36 1.39e-11 Asthma; CRC trans rs10242455 0.850 rs3779354 chr7:99052428 T/C cg09045935 chr12:6379348 NA 0.72 7.37 0.38 1.38e-12 Blood metabolite levels; CRC cis rs7809950 1.000 rs2057837 chr7:107222725 C/G cg23024343 chr7:107201750 COG5 0.6 8.7 0.43 1.65e-16 Coronary artery disease; CRC cis rs775227 0.574 rs13064411 chr3:113046640 A/G cg18753928 chr3:113234510 CCDC52 -0.56 -6.66 -0.34 1.18e-10 Dental caries; CRC cis rs62229266 0.633 rs34259635 chr21:37403570 T/G cg12218747 chr21:37451666 NA -0.37 -6.19 -0.32 1.8e-9 Mitral valve prolapse; CRC cis rs9309473 1.000 rs13421462 chr2:73719875 A/C cg20560298 chr2:73613845 ALMS1 -0.49 -5.97 -0.31 5.99e-9 Metabolite levels; CRC cis rs6088590 0.523 rs6088536 chr20:33189106 T/C cg08999081 chr20:33150536 PIGU 0.65 12.43 0.57 2.4e-29 Coronary artery disease; CRC cis rs561341 1.000 rs501312 chr17:30329066 A/G cg19193384 chr17:30244184 NA -0.65 -7.58 -0.39 3.51e-13 Hip circumference adjusted for BMI; CRC trans rs6956675 0.958 rs7779974 chr7:62576724 T/C cg01314568 chr7:57830625 NA -0.67 -9.26 -0.45 2.7e-18 Obesity-related traits; CRC cis rs2295359 1.000 rs11209006 chr1:67619259 T/G cg03340356 chr1:67600835 NA 0.24 5.78 0.3 1.71e-8 Psoriasis; CRC cis rs801193 0.660 rs974239 chr7:66213491 G/A cg18912574 chr7:65842487 NCRNA00174 0.35 5.9 0.31 8.96e-9 Aortic root size; CRC cis rs2014572 0.967 rs11084492 chr19:57756026 A/T cg24459738 chr19:57751996 ZNF805 -0.53 -8.19 -0.41 5.93e-15 Hyperactive-impulsive symptoms; CRC cis rs6831352 0.837 rs2924583 chr4:100044640 T/C cg13256891 chr4:100009986 ADH5 0.65 8.93 0.44 3.15e-17 Alcohol dependence; CRC cis rs1669338 0.588 rs62228620 chr3:3184913 C/T cg16797762 chr3:3221439 CRBN -0.6 -5.82 -0.31 1.36e-8 White matter integrity; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg19547976 chr4:1737009 TACC3 -0.34 -6.05 -0.32 3.9e-9 Liver disease severity in Alagille syndrome; CRC cis rs12477438 0.765 rs10181422 chr2:99558970 A/G cg26064155 chr2:99771622 LIPT1;TSGA10 -0.62 -8.6 -0.43 3.22e-16 Chronic sinus infection; CRC cis rs6754311 0.731 rs7569057 chr2:136583958 A/C cg15123519 chr2:136567270 LCT -0.35 -6.92 -0.36 2.35e-11 Mosquito bite size; CRC cis rs3026101 0.671 rs8077471 chr17:5299356 C/T cg25236894 chr17:5323110 RPAIN;NUP88 0.42 6.9 0.36 2.74e-11 Body mass index; CRC cis rs556990 0.574 rs473598 chr13:113801189 C/T cg18105134 chr13:113819100 PROZ -0.5 -6.44 -0.33 4.26e-10 Blood protein levels; CRC cis rs7312933 0.531 rs1796380 chr12:42791543 T/G cg19980929 chr12:42632907 YAF2 -0.4 -6.15 -0.32 2.3e-9 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CRC cis rs9467711 0.591 rs56294283 chr6:25976099 A/G cg08501292 chr6:25962987 TRIM38 0.83 7.52 0.38 5.14e-13 Autism spectrum disorder or schizophrenia; CRC cis rs76419734 0.510 rs2553461 chr4:106731410 A/G cg24545054 chr4:106630052 GSTCD;INTS12 -0.54 -6.18 -0.32 1.87e-9 Post bronchodilator FEV1; CRC cis rs35110281 0.667 rs2155722 chr21:45096206 A/G cg04455712 chr21:45112962 RRP1B -0.43 -8.4 -0.42 1.4e-15 Mean corpuscular volume; CRC cis rs853679 0.517 rs9295758 chr6:28120663 C/G cg02631126 chr6:28058918 ZSCAN12L1 0.29 5.91 0.31 8.38e-9 Depression; CRC cis rs59918340 0.764 rs10107024 chr8:142227592 T/C cg23750338 chr8:142222470 SLC45A4 0.6 11.08 0.52 1.79e-24 Immature fraction of reticulocytes; CRC cis rs8180040 0.701 rs62248439 chr3:46996448 A/G cg10298567 chr3:47292165 KIF9 0.38 5.95 0.31 6.96e-9 Colorectal cancer; CRC cis rs7927771 0.864 rs3781625 chr11:47443080 T/C cg05585544 chr11:47624801 NA -0.52 -9.41 -0.46 8.6e-19 Subjective well-being; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg21037892 chr2:96874728 STARD7 0.44 6.33 0.33 8.13e-10 Response to antipsychotic treatment; CRC cis rs67311347 1.000 rs73078169 chr3:40483798 G/A cg09455208 chr3:40491958 NA 0.49 9.63 0.47 1.66e-19 Renal cell carcinoma; CRC cis rs9534288 0.833 rs56813530 chr13:46622039 A/C cg15192986 chr13:46630673 CPB2 -0.74 -10.26 -0.49 1.29e-21 Blood protein levels; CRC cis rs10504229 0.906 rs6990615 chr8:58182956 G/A cg02290350 chr8:58132656 NA -0.42 -5.96 -0.31 6.62e-9 Developmental language disorder (linguistic errors); CRC cis rs9308731 0.644 rs1821968 chr2:111880623 C/T cg18646521 chr2:111875858 NA 0.39 6.2 0.32 1.64e-9 Chronic lymphocytic leukemia; CRC cis rs6964587 0.626 rs2269810 chr7:91508837 T/C cg17063962 chr7:91808500 NA -0.56 -8.84 -0.44 6.03e-17 Breast cancer; CRC cis rs12497850 0.931 rs3774628 chr3:48801840 C/T cg20833759 chr3:49053208 WDR6;DALRD3 0.48 8.03 0.4 1.7e-14 Parkinson's disease; CRC cis rs9916302 0.861 rs12150493 chr17:37586154 T/C cg00129232 chr17:37814104 STARD3 -0.54 -8.12 -0.41 9.26e-15 Glomerular filtration rate (creatinine); CRC cis rs62458065 0.850 rs28693551 chr7:32469387 G/A cg20159608 chr7:32802032 NA -0.56 -6.75 -0.35 6.67e-11 Metabolite levels (HVA/MHPG ratio); CRC cis rs6809651 0.524 rs4686730 chr3:185805993 C/T cg00760338 chr3:185826511 ETV5 -0.72 -9.17 -0.45 5.4e-18 Body mass index in physically active individuals;Glomerular filtration rate (creatinine);Body mass index (joint analysis main effects and physical activity interaction);Body mass index;Body mass index in physically inactive individuals; CRC cis rs3996993 0.839 rs9382146 chr6:52702085 G/A cg20803780 chr6:52668592 GSTA1 -0.36 -6.74 -0.35 7.25e-11 Hemoglobin concentration; CRC cis rs6502050 0.835 rs56095560 chr17:80151304 C/T cg19223190 chr17:80058835 NA 0.39 6.21 0.32 1.62e-9 Life satisfaction; CRC cis rs9322193 0.847 rs880246 chr6:150167108 G/A cg13206674 chr6:150067644 NUP43 0.66 9.74 0.47 7.39e-20 Lung cancer; CRC cis rs6499255 1.000 rs12925371 chr16:69773885 G/A cg15192750 chr16:69999425 NA 0.58 7.69 0.39 1.69e-13 IgE levels; CRC cis rs1552244 1.000 rs17032396 chr3:10153559 A/G cg13047869 chr3:10149882 C3orf24 -0.56 -7.68 -0.39 1.81e-13 Alzheimer's disease; CRC cis rs4665809 0.590 rs10197494 chr2:26445550 A/G cg27170947 chr2:26402098 FAM59B -0.59 -7.71 -0.39 1.53e-13 Gut microbiome composition (summer); CRC cis rs7191700 0.673 rs12325495 chr16:11418328 C/T cg00044050 chr16:11439710 C16orf75 0.57 8.54 0.43 5.15e-16 Multiple sclerosis; CRC trans rs7027930 0.524 rs58960694 chr9:614630 G/A cg27061366 chr19:13044373 FARSA 0.51 6.41 0.33 5.03e-10 Pulmonary function decline; CRC cis rs6582630 0.513 rs1596446 chr12:38282160 C/T cg13010199 chr12:38710504 ALG10B -0.44 -6.03 -0.32 4.39e-9 Drug-induced liver injury (flucloxacillin); CRC cis rs4728302 0.838 rs755664 chr7:133596671 C/G cg03336402 chr7:133662267 EXOC4 -0.44 -6.34 -0.33 7.53e-10 Intelligence;Intelligence (multi-trait analysis); CRC cis rs6570726 0.791 rs435671 chr6:145881215 A/G cg13319975 chr6:146136371 FBXO30 -0.44 -6.52 -0.34 2.66e-10 Lobe attachment (rater-scored or self-reported); CRC cis rs13118159 0.801 rs13147602 chr4:1332175 A/G cg15763984 chr4:1342303 KIAA1530 0.5 8.42 0.42 1.17e-15 Longevity; CRC cis rs7075426 0.669 rs10887608 chr10:88191938 A/G cg07322936 chr10:88137208 NA -0.41 -5.69 -0.3 2.78e-8 Migraine without aura; CRC cis rs1799949 1.000 rs11658754 chr17:41292739 G/A cg01879757 chr17:41196368 BRCA1 -0.44 -6.67 -0.35 1.06e-10 Menopause (age at onset); CRC cis rs597539 0.689 rs596874 chr11:68630874 C/T cg21963583 chr11:68658836 MRPL21 -0.55 -10.59 -0.5 9.62e-23 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg07083667 chr17:5342657 C1QBP 0.39 6.33 0.33 8.05e-10 Liver disease severity in Alagille syndrome; CRC cis rs6684514 1.000 rs28372828 chr1:156253031 G/C cg16558208 chr1:156270281 VHLL 0.59 9.2 0.45 4.08e-18 Mean corpuscular hemoglobin concentration;Glycated hemoglobin levels; CRC cis rs13108904 0.901 rs1316394 chr4:1315820 G/A cg21620606 chr4:1342894 KIAA1530 0.34 5.62 0.3 4.15e-8 Obesity-related traits; CRC cis rs17345786 1.000 rs17345786 chr3:101318318 A/C cg03837452 chr3:101395095 ZBTB11;LOC100009676 -0.58 -6.88 -0.35 2.94e-11 Colonoscopy-negative controls vs population controls; CRC cis rs3771570 0.818 rs73008126 chr2:242443157 A/C cg21155796 chr2:242212141 HDLBP 0.62 6.54 0.34 2.4e-10 Prostate cancer; CRC cis rs5167 0.525 rs10402642 chr19:45453878 G/A cg13119609 chr19:45449297 APOC2 0.31 5.81 0.3 1.5e-8 Blood protein levels; CRC cis rs73206853 0.620 rs28720928 chr12:111126609 C/T cg12870014 chr12:110450643 ANKRD13A 0.74 7.49 0.38 6.39e-13 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC cis rs10089 1.000 rs73337363 chr5:127483597 A/G cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.74 10.4 0.5 4.25e-22 Ileal carcinoids; CRC cis rs8177253 0.965 rs4854761 chr3:133498789 A/G cg01448562 chr3:133502909 NA 0.52 8.87 0.44 4.9e-17 Iron status biomarkers; CRC trans rs9929218 0.953 rs12930910 chr16:68762520 A/G cg04657470 chr2:198365150 HSPE1;HSPD1 -0.97 -14.46 -0.62 4.86e-37 Colorectal cancer; CRC cis rs9733 0.593 rs10888384 chr1:150574256 C/T cg17724175 chr1:150552817 MCL1 -0.54 -8.9 -0.44 3.78e-17 Tonsillectomy; CRC cis rs2857891 0.817 rs2857899 chr11:6981668 A/C cg04053776 chr11:6947353 ZNF215 0.39 5.72 0.3 2.37e-8 Response to cytadine analogues (cytosine arabinoside); CRC cis rs2565722 0.713 rs2465867 chr6:161285463 G/A cg03159191 chr6:161285451 NA -0.47 -6.29 -0.33 1e-9 Blood protein levels; CRC cis rs11098499 0.754 rs28643450 chr4:120245242 G/A cg09307838 chr4:120376055 NA 0.62 9.58 0.47 2.54e-19 Corneal astigmatism; CRC cis rs8180040 0.966 rs34634681 chr3:47579102 G/A cg27129171 chr3:47204927 SETD2 -0.6 -9.01 -0.44 1.73e-17 Colorectal cancer; CRC cis rs6433857 0.536 rs12464424 chr2:181349137 A/G cg23363182 chr2:181467187 NA -0.52 -7.6 -0.39 3.1e-13 Body mass index; CRC cis rs9549367 0.662 rs3818334 chr13:113825174 C/G cg00898013 chr13:113819073 PROZ -0.59 -8.43 -0.42 1.1e-15 Platelet distribution width; CRC trans rs12943633 1.000 rs12943633 chr17:37970365 C/T cg24146408 chr3:15374317 SH3BP5 0.72 6.08 0.32 3.28e-9 Eosinophil percentage of white cells;Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; CRC cis rs2204008 0.639 rs7311462 chr12:38278130 G/A cg13010199 chr12:38710504 ALG10B 0.45 5.75 0.3 2.07e-8 Bladder cancer; CRC trans rs1656966 1.000 rs1656966 chr3:186466252 C/T cg06796825 chr17:17140633 FLCN 0.39 6.01 0.31 4.95e-9 Myopia (pathological); CRC cis rs11758351 0.660 rs113205297 chr6:26210808 A/C cg10723962 chr6:26240782 HIST1H4F -0.4 -6.62 -0.34 1.49e-10 Gout;Renal underexcretion gout; CRC cis rs4423214 1.000 rs4944955 chr11:71167677 C/T cg05163923 chr11:71159392 DHCR7 0.68 9.61 0.47 2e-19 Vitamin D levels; CRC cis rs68170813 0.559 rs74774133 chr7:106941449 T/C cg02696742 chr7:106810147 HBP1 -0.59 -6.62 -0.34 1.44e-10 Coronary artery disease; CRC cis rs2204008 0.805 rs10881112 chr12:37956611 G/A cg13010199 chr12:38710504 ALG10B -0.48 -7.04 -0.36 1.16e-11 Bladder cancer; CRC cis rs7113874 0.569 rs10769914 chr11:8576202 A/G cg20771178 chr11:8615675 STK33 -0.34 -5.61 -0.3 4.37e-8 Body mass index in physically active individuals;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs4481887 0.679 rs4466692 chr1:248423174 C/G cg00666640 chr1:248458726 OR2T12 0.51 8.68 0.43 1.91e-16 Common traits (Other); CRC cis rs1865760 0.566 rs9467663 chr6:26021456 C/G cg17691542 chr6:26056736 HIST1H1C 0.55 8.41 0.42 1.28e-15 Height; CRC cis rs977987 0.843 rs12149063 chr16:75451758 G/A cg03315344 chr16:75512273 CHST6 0.54 9.08 0.45 1.04e-17 Dupuytren's disease; CRC trans rs2727020 0.757 rs7924526 chr11:49267043 G/A cg03929089 chr4:120376271 NA 0.65 8.89 0.44 3.98e-17 Coronary artery disease; CRC cis rs798554 1.000 rs798545 chr7:2762386 C/T cg14895029 chr7:2775587 GNA12 -0.41 -6.17 -0.32 2.02e-9 Height; CRC cis rs5758511 0.596 rs55644935 chr22:42666069 A/G cg00645731 chr22:42541494 CYP2D7P1 0.59 8.91 0.44 3.62e-17 Birth weight; CRC cis rs747650 0.504 rs7126005 chr11:47041065 G/A cg19486271 chr11:47235900 DDB2 -0.44 -5.88 -0.31 1.03e-8 Acne (severe); CRC cis rs6860806 0.507 rs2631364 chr5:131706914 C/G cg24060327 chr5:131705240 SLC22A5 0.54 8.21 0.41 5.03e-15 Breast cancer; CRC cis rs1552244 1.000 rs68067759 chr3:10150535 T/C cg13047869 chr3:10149882 C3orf24 0.56 7.63 0.39 2.5e-13 Alzheimer's disease; CRC cis rs6912958 0.559 rs183599 chr6:88061024 C/T cg08069147 chr6:88032118 GJB7;C6orf162 0.68 11.15 0.52 1.03e-24 Monocyte percentage of white cells; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg24542852 chr12:569111 B4GALNT3 0.43 5.96 0.31 6.5e-9 Anxiety disorder; CRC cis rs17023223 0.537 rs12081327 chr1:119686358 A/G cg05756136 chr1:119680316 WARS2 -0.53 -7.3 -0.37 2.17e-12 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for BMI in active individuals; CRC cis rs10504229 1.000 rs58053450 chr8:58173348 T/C cg05313129 chr8:58192883 C8orf71 -0.47 -6.99 -0.36 1.49e-11 Developmental language disorder (linguistic errors); CRC cis rs6743376 0.532 rs2515403 chr2:113820732 T/C cg09040174 chr2:113837401 NA 0.4 5.84 0.31 1.22e-8 Inflammatory biomarkers; CRC cis rs8060686 0.841 rs73594554 chr16:67920049 G/A cg08314208 chr16:67682810 RLTPR -0.62 -7.01 -0.36 1.39e-11 HDL cholesterol;Metabolic syndrome; CRC cis rs4819052 0.851 rs1999333 chr21:46670401 C/G cg11663144 chr21:46675770 NA -0.84 -14.39 -0.62 9.73e-37 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs1008375 0.966 rs6825133 chr4:17577776 C/T cg16339924 chr4:17578868 LAP3 0.6 8.0 0.4 2.16e-14 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs2032447 0.966 rs9358901 chr6:26024436 G/T cg03517284 chr6:25882590 NA -0.44 -6.18 -0.32 1.87e-9 Intelligence (multi-trait analysis); CRC cis rs2836950 0.501 rs4818019 chr21:40694456 T/A cg17971929 chr21:40555470 PSMG1 -0.51 -7.26 -0.37 2.73e-12 Menarche (age at onset); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg22199115 chr12:90102575 LOC338758 0.45 7.17 0.37 5.07e-12 Liver disease severity in Alagille syndrome; CRC cis rs10463316 0.925 rs6877344 chr5:150742650 C/T cg03212797 chr5:150827313 SLC36A1 -0.43 -6.26 -0.33 1.18e-9 Metabolite levels (Pyroglutamine); CRC trans rs7647973 0.710 rs2029591 chr3:49646981 C/T cg21659725 chr3:3221576 CRBN 0.63 6.8 0.35 4.95e-11 Menarche (age at onset); CRC cis rs2153535 0.580 rs718502 chr6:8527400 T/C cg07606381 chr6:8435919 SLC35B3 0.67 10.85 0.51 1.23e-23 Motion sickness; CRC cis rs17155006 0.664 rs448559 chr7:107739485 A/G cg05962710 chr7:107745446 LAMB4 -0.43 -7.8 -0.4 8.12e-14 Pneumococcal bacteremia; CRC cis rs754466 1.000 rs12220902 chr10:79682918 C/T cg17075019 chr10:79541650 NA -0.71 -9.92 -0.48 1.78e-20 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs3820068 0.581 rs58425551 chr1:15922518 A/G cg24675056 chr1:15929824 NA 0.48 6.52 0.34 2.66e-10 Systolic blood pressure; CRC cis rs9894429 1.000 rs9747349 chr17:79584297 C/T cg21984481 chr17:79567631 NPLOC4 -0.53 -9.8 -0.48 4.52e-20 Eye color traits; CRC cis rs1129187 0.818 rs9462858 chr6:42946490 C/A cg02359409 chr6:42947317 PEX6 -0.58 -8.85 -0.44 5.33e-17 Alzheimer's disease in APOE e4+ carriers; CRC cis rs6456156 0.811 rs975822 chr6:167516458 C/T cg07741184 chr6:167504864 NA -0.33 -5.82 -0.31 1.4e-8 Primary biliary cholangitis; CRC cis rs7584330 0.518 rs6715245 chr2:238445803 C/T cg14458575 chr2:238380390 NA 0.79 10.05 0.48 6.85e-21 Prostate cancer; CRC cis rs1656402 1.000 rs1550097 chr2:233428275 C/T cg03852847 chr2:233439513 NA 0.45 7.59 0.39 3.35e-13 Non-small cell lung cancer (survival); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg13565152 chr9:35815219 HINT2 0.41 6.28 0.33 1.06e-9 Liver disease severity in Alagille syndrome; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg16406212 chr2:24163862 UBXN2A 0.46 6.61 0.34 1.59e-10 Response to antipsychotic treatment; CRC cis rs7937682 0.924 rs7924683 chr11:111555796 C/A cg09085632 chr11:111637200 PPP2R1B -1.01 -20.88 -0.75 3.09e-62 Primary sclerosing cholangitis; CRC cis rs35306767 0.714 rs7075188 chr10:1088746 G/T cg26597838 chr10:835615 NA -0.61 -8.1 -0.41 1.11e-14 Eosinophil percentage of granulocytes; CRC cis rs801193 0.742 rs9969300 chr7:65781646 G/A cg18876405 chr7:65276391 NA -0.51 -8.91 -0.44 3.44e-17 Aortic root size; CRC cis rs3858526 0.752 rs11040173 chr11:6009378 A/G cg13902645 chr11:5959945 NA 0.51 6.53 0.34 2.45e-10 DNA methylation (variation); CRC trans rs7726839 0.540 rs56325086 chr5:640728 G/A cg25482853 chr8:67687455 SGK3 1.11 12.96 0.58 2.49e-31 Obesity-related traits; CRC cis rs10751667 0.714 rs7395879 chr11:963855 G/C cg23136738 chr11:925521 AP2A2 -0.42 -7.09 -0.36 8.19e-12 Alzheimer's disease (late onset); CRC cis rs9372498 0.536 rs55899435 chr6:118812099 C/T cg15382696 chr6:118971807 C6orf204 0.62 8.05 0.41 1.53e-14 Diastolic blood pressure; CRC cis rs2290405 0.527 rs4690329 chr4:931385 T/A cg04824913 chr4:887549 GAK 0.71 10.4 0.5 4.47e-22 Systemic sclerosis; CRC cis rs9325144 0.647 rs61937754 chr12:39060543 T/C cg26384229 chr12:38710491 ALG10B -0.53 -7.46 -0.38 7.59e-13 Morning vs. evening chronotype; CRC cis rs7647973 0.593 rs62262730 chr3:49808274 T/G cg13072238 chr3:49761600 GMPPB 0.52 5.7 0.3 2.68e-8 Menarche (age at onset); CRC cis rs868036 1.000 rs4776974 chr15:68095927 G/A cg05925327 chr15:68127851 NA -0.31 -6.03 -0.32 4.4e-9 Restless legs syndrome; CRC cis rs1218582 0.772 rs6699043 chr1:154913021 T/C cg09359103 chr1:154839909 KCNN3 -0.7 -12.19 -0.56 1.9e-28 Prostate cancer; CRC trans rs61931739 0.517 rs10844815 chr12:34245150 G/A cg26384229 chr12:38710491 ALG10B 0.53 6.7 0.35 8.91e-11 Morning vs. evening chronotype; CRC cis rs13191362 1.000 rs34344906 chr6:162993378 T/C cg06582575 chr6:163149167 PACRG;PARK2 0.8 10.98 0.52 4.33e-24 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs9303280 0.651 rs59716545 chr17:38031857 T/G cg11212589 chr17:38028394 ZPBP2 0.43 7.92 0.4 3.63e-14 Self-reported allergy; CRC cis rs3126085 0.935 rs11204951 chr1:152224404 A/G cg09127314 chr1:152161683 NA 0.48 6.18 0.32 1.9e-9 Atopic dermatitis; CRC cis rs1355223 1.000 rs12792532 chr11:34765782 G/T cg11058730 chr11:34937778 PDHX;APIP -0.46 -6.5 -0.34 2.95e-10 Systemic lupus erythematosus and Systemic sclerosis; CRC trans rs10242455 0.571 rs41258334 chr7:99271808 T/C cg09045935 chr12:6379348 NA 0.84 6.31 0.33 8.84e-10 Blood metabolite levels; CRC cis rs2839186 0.656 rs8128380 chr21:47665693 C/T cg00612595 chr21:47717864 NA -0.34 -5.66 -0.3 3.23e-8 Testicular germ cell tumor; CRC cis rs12024301 0.557 rs10911407 chr1:183658546 T/C cg11505048 chr1:183622726 RGL1;APOBEC4 0.71 6.24 0.33 1.33e-9 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs679087 1.000 rs302315 chr12:29919054 G/C cg14258853 chr12:29935411 TMTC1 -0.46 -7.89 -0.4 4.41e-14 Schizophrenia; CRC cis rs875971 0.862 rs908915 chr7:65614651 G/T cg18876405 chr7:65276391 NA -0.51 -8.44 -0.42 1.02e-15 Aortic root size; CRC cis rs28386778 0.897 rs2584642 chr17:61942427 T/C cg22520471 chr17:61851767 DDX42;CCDC47 0.73 11.49 0.54 6.52e-26 Prudent dietary pattern; CRC cis rs7811142 0.830 rs28495773 chr7:99943583 A/T cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.95 11.77 0.54 6.37e-27 Platelet count; CRC trans rs10277209 1.000 rs10277209 chr7:109003574 A/G cg13575011 chr19:16022472 NA -0.48 -6.1 -0.32 2.93e-9 Prostate cancer (SNP x SNP interaction); CRC cis rs6598955 0.543 rs61608823 chr1:26555090 G/A cg04990556 chr1:26633338 UBXN11 0.88 10.68 0.51 4.85e-23 Obesity-related traits; CRC cis rs9487051 0.676 rs13195816 chr6:109598624 T/C cg01475377 chr6:109611718 NA -0.37 -6.42 -0.33 4.8e-10 Reticulocyte fraction of red cells; CRC cis rs59901009 0.863 rs2278634 chr11:10184463 C/A cg23875677 chr11:10229755 SBF2 -0.48 -6.06 -0.32 3.73e-9 Hematocrit;Hemoglobin concentration; CRC cis rs2814982 0.605 rs114032116 chr6:34468333 C/T cg17674042 chr6:34482479 PACSIN1 -1.01 -11.04 -0.52 2.63e-24 Cholesterol, total;Total cholesterol levels; CRC trans rs7267979 0.966 rs4815414 chr20:25361701 A/G cg17903999 chr18:56338584 MALT1 0.42 6.94 0.36 2.1e-11 Liver enzyme levels (alkaline phosphatase); CRC cis rs1218582 0.772 rs4240874 chr1:154885779 C/T cg16680214 chr1:154839983 KCNN3 -0.45 -8.86 -0.44 5.13e-17 Prostate cancer; CRC cis rs931127 0.658 rs4244812 chr11:65480768 A/G cg27068330 chr11:65405492 SIPA1 -0.43 -5.9 -0.31 9e-9 Systemic lupus erythematosus; CRC trans rs2553218 0.690 rs8032415 chr15:54851945 A/G cg12859382 chr3:52445103 PHF7;BAP1 0.45 6.09 0.32 3.08e-9 Immune response to smallpox vaccine (IL-6); CRC cis rs2731664 0.765 rs2630766 chr5:176874941 A/C cg23176889 chr5:176863531 GRK6 -0.75 -16.52 -0.67 4.6e-45 Intelligence (multi-trait analysis); CRC cis rs9650657 0.537 rs11250092 chr8:10786543 A/G cg27411982 chr8:10470053 RP1L1 0.41 6.19 0.32 1.84e-9 Neuroticism; CRC trans rs1346081 0.786 rs1425645 chr4:68028175 C/T cg26410121 chr1:144521081 LOC728875 0.51 6.21 0.32 1.56e-9 Intelligence (multi-trait analysis); CRC cis rs853679 0.599 rs149949 chr6:28011516 T/C cg06470822 chr6:28175283 NA 0.75 7.13 0.37 6.35e-12 Depression; CRC cis rs3218092 0.872 rs3218086 chr6:41910064 C/T cg17623882 chr6:41773611 USP49 0.47 5.61 0.3 4.4e-8 Red cell distribution width; CRC cis rs13191362 1.000 rs13218900 chr6:163081638 T/C cg06582575 chr6:163149167 PACRG;PARK2 0.93 11.84 0.55 3.47e-27 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs7680126 0.596 rs12503603 chr4:10313757 T/G cg00071950 chr4:10020882 SLC2A9 -0.52 -6.55 -0.34 2.24e-10 Urate levels in lean individuals;Urate levels in overweight individuals;Urate levels in obese individuals; CRC cis rs11155671 0.530 rs9371544 chr6:150217360 A/G cg13206674 chr6:150067644 NUP43 0.52 7.48 0.38 6.73e-13 Testicular germ cell tumor; CRC cis rs2952156 1.000 rs2934971 chr17:37854507 G/T cg00129232 chr17:37814104 STARD3 -0.7 -11.57 -0.54 3.31e-26 Asthma; CRC cis rs189798 0.807 rs330905 chr8:8993551 A/T cg06636001 chr8:8085503 FLJ10661 0.48 6.57 0.34 2.02e-10 Myopia (pathological); CRC cis rs9300255 0.544 rs1716174 chr12:123660717 T/C cg00376283 chr12:123451042 ABCB9 0.58 6.65 0.34 1.22e-10 Neutrophil percentage of white cells; CRC trans rs10506458 0.915 rs12424908 chr12:63402364 G/A cg22491629 chr6:157744540 C6orf35 -0.79 -9.46 -0.46 6.17e-19 Hemostatic factors and hematological phenotypes; CRC trans rs11098499 0.863 rs13136462 chr4:120543173 C/T cg25214090 chr10:38739885 LOC399744 0.67 10.24 0.49 1.54e-21 Corneal astigmatism; CRC cis rs9527 0.590 rs2182348 chr10:104872684 A/G cg15744005 chr10:104629667 AS3MT -0.31 -6.12 -0.32 2.69e-9 Arsenic metabolism; CRC cis rs7208859 0.623 rs11652631 chr17:29060766 A/G cg01831904 chr17:28903510 LRRC37B2 -0.61 -6.22 -0.32 1.52e-9 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs9311474 0.539 rs12489828 chr3:52567014 G/T cg18099408 chr3:52552593 STAB1 -0.57 -11.04 -0.52 2.52e-24 Electroencephalogram traits; CRC cis rs11250464 0.833 rs11250467 chr10:1409662 A/G cg26394196 chr10:1453818 ADARB2 -0.33 -5.83 -0.31 1.34e-8 Radiation response; CRC cis rs6459804 0.566 rs113592117 chr7:157511889 C/A cg15733309 chr7:157513707 PTPRN2 0.41 6.83 0.35 4.18e-11 Bipolar disorder and schizophrenia; CRC trans rs11252926 0.589 rs12359901 chr10:475068 A/G cg00953403 chr17:74099816 EXOC7 -0.5 -7.42 -0.38 1.01e-12 Psychosis in Alzheimer's disease; CRC trans rs1997103 0.954 rs9649854 chr7:55410213 G/A cg20935933 chr6:143382018 AIG1 0.5 6.54 0.34 2.38e-10 QRS interval (sulfonylurea treatment interaction); CRC cis rs7224685 0.501 rs2054038 chr17:4014391 A/C cg09695851 chr17:3907499 NA 0.65 11.29 0.53 3.23e-25 Type 2 diabetes; CRC cis rs6500395 0.926 rs11076571 chr16:48598064 A/G cg04672837 chr16:48644449 N4BP1 0.42 5.99 0.31 5.43e-9 Response to tocilizumab in rheumatoid arthritis; CRC cis rs911119 1.000 rs6114208 chr20:23621734 C/G cg16589663 chr20:23618590 CST3 0.62 8.05 0.41 1.51e-14 Chronic kidney disease; CRC cis rs10744422 0.858 rs4759389 chr12:123308615 A/G cg25930673 chr12:123319894 HIP1R -0.58 -6.18 -0.32 1.86e-9 Schizophrenia; CRC cis rs10883723 0.738 rs715438 chr10:104258303 C/T cg22532475 chr10:104410764 TRIM8 -0.36 -6.58 -0.34 1.9e-10 Allergic disease (asthma, hay fever or eczema); CRC cis rs4243830 0.850 rs4908915 chr1:6601607 T/C cg05709478 chr1:6581295 PLEKHG5 -0.53 -5.96 -0.31 6.42e-9 Body mass index; CRC cis rs12824058 0.831 rs4759658 chr12:130815872 C/T cg24838063 chr12:130822603 PIWIL1 0.59 9.98 0.48 1.13e-20 Menopause (age at onset); CRC cis rs3026101 0.671 rs1143206 chr17:5284698 A/G cg25236894 chr17:5323110 RPAIN;NUP88 0.45 7.47 0.38 7.09e-13 Body mass index; CRC cis rs2195987 0.914 rs10416636 chr19:24108447 A/T cg00460763 chr19:23944615 RPSAP58 0.53 5.93 0.31 7.49e-9 Testicular germ cell tumor; CRC trans rs17126268 0.605 rs1856776 chr1:102876616 T/C cg18468354 chr14:36993517 NA 0.39 6.14 0.32 2.37e-9 Glomerular filtration rate; CRC cis rs9311474 0.629 rs4282054 chr3:52566065 T/C cg15147215 chr3:52552868 STAB1 -0.79 -16.29 -0.67 3.75e-44 Electroencephalogram traits; CRC cis rs796364 0.806 rs203765 chr2:200903020 G/A cg23649088 chr2:200775458 C2orf69 -0.63 -6.26 -0.33 1.22e-9 Schizophrenia; CRC cis rs4713118 0.869 rs9348775 chr6:27695329 C/T cg06470822 chr6:28175283 NA 0.68 9.44 0.46 6.91e-19 Parkinson's disease; CRC cis rs10493773 0.609 rs11161656 chr1:86182414 A/G cg00734567 chr1:86172782 ZNHIT6 -0.48 -7.38 -0.38 1.33e-12 Urate levels in overweight individuals; CRC cis rs2281845 0.507 rs942703 chr1:201092979 A/G cg22815214 chr1:201083145 CACNA1S -0.51 -6.42 -0.33 4.67e-10 Permanent tooth development; CRC cis rs9463078 0.669 rs7750380 chr6:45070034 A/G cg25276700 chr6:44698697 NA -0.25 -5.94 -0.31 7.4e-9 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; CRC cis rs243505 0.708 rs243548 chr7:148396549 G/A cg09806900 chr7:148480153 CUL1 -0.44 -5.61 -0.3 4.24e-8 Inflammatory bowel disease;Crohn's disease; CRC trans rs9291683 0.632 rs11734786 chr4:10041499 A/C cg26043149 chr18:55253948 FECH 0.53 8.17 0.41 6.79e-15 Bone mineral density; CRC cis rs3996993 0.597 rs62412900 chr6:52721568 C/T cg20803780 chr6:52668592 GSTA1 0.39 6.84 0.35 3.96e-11 Hemoglobin concentration; CRC cis rs7811142 1.000 rs60844404 chr7:100080474 A/T cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.73 9.87 0.48 2.71e-20 Platelet count; CRC cis rs4664293 0.967 rs35975814 chr2:160547791 G/A cg08347373 chr2:160653686 CD302 -0.44 -7.18 -0.37 4.55e-12 Monocyte percentage of white cells; CRC cis rs524281 0.773 rs79770412 chr11:66045344 G/C cg16950941 chr11:66035639 RAB1B -0.72 -8.07 -0.41 1.3e-14 Electroencephalogram traits; CRC cis rs9527 0.615 rs10883810 chr10:104727224 A/C cg04362960 chr10:104952993 NT5C2 0.6 8.55 0.43 4.74e-16 Arsenic metabolism; CRC cis rs2243480 1.000 rs36033484 chr7:65390558 T/G cg25985355 chr7:65971099 NA -0.48 -5.65 -0.3 3.53e-8 Diabetic kidney disease; CRC cis rs12477438 0.520 rs6708576 chr2:99801308 G/A cg14399236 chr2:99771627 LIPT1;TSGA10 0.79 13.77 0.6 2.29e-34 Chronic sinus infection; CRC cis rs1256061 0.603 rs1152579 chr14:64695087 A/G cg23250157 chr14:64679961 SYNE2 0.48 7.53 0.38 5.04e-13 Hemoglobin concentration;Red blood cell count;Hematocrit; CRC cis rs11122272 0.735 rs2790891 chr1:231513190 G/A cg06096015 chr1:231504339 EGLN1 0.4 5.95 0.31 6.7e-9 Hemoglobin concentration; CRC cis rs7264396 0.635 rs6060720 chr20:34548336 A/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.61 -9.83 -0.48 3.75e-20 Total cholesterol levels; CRC trans rs17685 0.712 rs10271413 chr7:75754858 G/A cg19862616 chr7:65841803 NCRNA00174 0.98 17.96 0.7 9.17e-51 Coffee consumption;Coffee consumption (cups per day); CRC cis rs9611565 0.592 rs8779 chr22:42070276 T/C cg06634786 chr22:41940651 POLR3H 0.61 6.86 0.35 3.38e-11 Vitiligo; CRC cis rs7193541 0.684 rs4888264 chr16:74681632 T/G cg01733217 chr16:74700730 RFWD3 1.05 22.23 0.77 1.67e-67 Multiple myeloma; CRC cis rs78456975 1.000 rs11891809 chr2:1566001 A/G cg12573674 chr2:1569213 NA -0.72 -7.73 -0.39 1.34e-13 Placebo response in major depressive disorder (% change in symptom score); CRC cis rs992157 0.735 rs2271541 chr2:219082119 G/T cg04731861 chr2:219085781 ARPC2 -0.31 -6.56 -0.34 2.12e-10 Colorectal cancer; CRC cis rs7937682 0.921 rs12806479 chr11:111443192 G/C cg19812747 chr11:111475976 SIK2 0.52 7.55 0.38 4.2e-13 Primary sclerosing cholangitis; CRC cis rs728616 0.867 rs12415870 chr10:81949470 A/G cg05935833 chr10:81318306 SFTPA2 -0.72 -7.91 -0.4 3.91e-14 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs7945705 0.791 rs10769958 chr11:8815115 T/C cg21881798 chr11:8931708 C11orf17;ST5 -0.57 -9.38 -0.46 1.11e-18 Hemoglobin concentration; CRC cis rs13088645 0.532 rs9835166 chr3:134166224 G/A cg06109529 chr3:134205091 CEP63;ANAPC13 0.49 6.71 0.35 8.6e-11 Coronary artery disease; CRC cis rs6840360 0.571 rs875668 chr4:152525661 C/T cg09659197 chr4:152720779 NA 0.32 5.81 0.31 1.46e-8 Intelligence (multi-trait analysis); CRC cis rs35110281 0.693 rs4819290 chr21:45122713 C/T cg04455712 chr21:45112962 RRP1B 0.4 7.66 0.39 2.08e-13 Mean corpuscular volume; CRC cis rs7640424 0.819 rs179046 chr3:107840773 A/C cg09227934 chr3:107805635 CD47 -0.41 -6.23 -0.33 1.39e-9 Body mass index; CRC cis rs12541335 0.639 rs7834182 chr8:22163112 G/A cg27266060 chr8:22091797 NA 0.36 6.17 0.32 2e-9 Hypertriglyceridemia; CRC cis rs1552244 1.000 rs68045038 chr3:10151828 A/G cg02579736 chr3:10068473 FANCD2;CIDECP 1.03 13.67 0.6 5.38e-34 Alzheimer's disease; CRC cis rs7666738 0.830 rs11938686 chr4:98964470 A/G cg05340658 chr4:99064831 C4orf37 0.58 8.86 0.44 5.16e-17 Colonoscopy-negative controls vs population controls; CRC cis rs7666738 0.962 rs17550217 chr4:98999699 T/A cg17366294 chr4:99064904 C4orf37 0.45 7.33 0.37 1.75e-12 Colonoscopy-negative controls vs population controls; CRC cis rs2228479 0.850 rs12596934 chr16:89841605 T/G cg06558623 chr16:89946397 TCF25 1.09 10.23 0.49 1.69e-21 Skin colour saturation; CRC cis rs2952156 0.883 rs907088 chr17:37833567 G/C cg00129232 chr17:37814104 STARD3 -0.68 -12.01 -0.55 8.36e-28 Asthma; CRC cis rs909674 0.818 rs8137426 chr22:39844350 T/G cg24399712 chr22:39784796 NA -0.41 -7.69 -0.39 1.7e-13 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; CRC cis rs801193 0.591 rs9986881 chr7:66173040 A/G cg18876405 chr7:65276391 NA 0.46 7.42 0.38 1.02e-12 Aortic root size; CRC cis rs1552244 0.882 rs2130813 chr3:10038706 A/C cg18598329 chr3:10140678 FANCD2;C3orf24 -0.81 -10.55 -0.5 1.36e-22 Alzheimer's disease; CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg15985338 chr7:6048868 PMS2;AIMP2 0.46 7.64 0.39 2.44e-13 Obesity-related traits; CRC cis rs57221529 0.825 rs7443550 chr5:578404 G/T cg17948913 chr5:572064 NA 0.56 6.25 0.33 1.28e-9 Lung disease severity in cystic fibrosis; CRC cis rs1005277 0.522 rs289648 chr10:37971837 T/C cg25517755 chr10:38738941 LOC399744 -0.4 -5.67 -0.3 3.11e-8 Extrinsic epigenetic age acceleration; CRC cis rs10744422 1.000 rs1532835 chr12:123330665 G/A cg25930673 chr12:123319894 HIP1R -0.6 -6.32 -0.33 8.63e-10 Schizophrenia; CRC cis rs1552244 0.554 rs6768339 chr3:10006079 G/T cg08888203 chr3:10149979 C3orf24 -0.48 -7.27 -0.37 2.58e-12 Alzheimer's disease; CRC cis rs4588572 0.643 rs1529499 chr5:77721431 T/C cg11547950 chr5:77652471 NA -0.53 -7.25 -0.37 2.92e-12 Triglycerides; CRC cis rs60733400 0.667 rs4385650 chr1:2499898 G/A cg20673091 chr1:2541236 MMEL1 0.35 5.63 0.3 3.88e-8 Multiple sclerosis; CRC cis rs7089973 0.872 rs36036948 chr10:116631649 A/G cg23260525 chr10:116636907 FAM160B1 0.32 6.94 0.36 2.04e-11 Bipolar disorder or attention deficit hyperactivity disorder; CRC trans rs7395662 0.895 rs1827971 chr11:48718502 C/G cg21153622 chr11:89784906 NA -0.48 -7.72 -0.39 1.45e-13 HDL cholesterol; CRC cis rs769267 0.930 rs892022 chr19:19613381 G/A cg01262667 chr19:19385393 TM6SF2 0.36 5.86 0.31 1.11e-8 Tonsillectomy; CRC cis rs921968 0.608 rs832817 chr2:219358603 C/T cg02176678 chr2:219576539 TTLL4 0.48 7.96 0.4 2.84e-14 Mean corpuscular hemoglobin concentration; CRC cis rs1046896 0.553 rs1044661 chr17:80901020 G/A cg19046167 chr17:80928561 B3GNTL1 0.51 7.34 0.38 1.65e-12 Glycated hemoglobin levels; CRC cis rs72634258 0.945 rs34466510 chr1:8147412 T/C cg00042356 chr1:8021962 PARK7 0.7 7.39 0.38 1.24e-12 Inflammatory bowel disease; CRC cis rs7618915 0.508 rs7628578 chr3:52628321 A/T cg05573699 chr3:52720067 GNL3;PBRM1 -0.47 -6.86 -0.35 3.41e-11 Bipolar disorder; CRC cis rs9650657 0.562 rs10090444 chr8:10745469 C/G cg27411982 chr8:10470053 RP1L1 0.41 6.33 0.33 8.11e-10 Neuroticism; CRC cis rs7591163 1.000 rs7591163 chr2:228715375 C/T cg22079747 chr2:228736145 WDR69 -0.44 -5.94 -0.31 7.4e-9 Blood pressure; CRC cis rs9435341 0.762 rs2878349 chr1:107549245 G/A cg03874509 chr1:107600012 PRMT6 0.44 6.0 0.31 5.22e-9 Facial morphology (factor 21, depth of nasal alae); CRC cis rs1005277 0.579 rs2474584 chr10:38416389 C/T cg00409905 chr10:38381863 ZNF37A -0.67 -11.13 -0.52 1.21e-24 Extrinsic epigenetic age acceleration; CRC cis rs7264396 0.635 rs6060660 chr20:34476649 T/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.61 -10.29 -0.49 1.03e-21 Total cholesterol levels; CRC cis rs2243480 1.000 rs316312 chr7:65596491 T/G cg25985355 chr7:65971099 NA -0.51 -5.87 -0.31 1.05e-8 Diabetic kidney disease; CRC cis rs7647973 0.710 rs6797299 chr3:49609794 G/T cg13072238 chr3:49761600 GMPPB -0.54 -5.85 -0.31 1.19e-8 Menarche (age at onset); CRC cis rs4917833 0.700 rs7067691 chr10:100221081 T/C cg19043522 chr10:100227446 HPSE2 0.38 5.81 0.3 1.5e-8 Pediatric bone mineral density (femoral neck); CRC trans rs6951245 1.000 rs76388414 chr7:1100694 G/A cg13565492 chr6:43139072 SRF -0.72 -7.44 -0.38 8.63e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC trans rs10983614 1.000 rs7867776 chr9:120072627 A/G cg06679760 chr3:49027156 P4HTM 0.48 6.34 0.33 7.51e-10 Survival in pancreatic cancer; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg16202187 chr19:17186497 HAUS8;MYO9B 0.39 6.0 0.31 5.34e-9 Intelligence (multi-trait analysis); CRC cis rs2732480 0.500 rs2732461 chr12:48692802 C/A cg21466736 chr12:48725269 NA -0.56 -8.36 -0.42 1.85e-15 Hemoglobin concentration;Red blood cell count;Hematocrit; CRC cis rs2243480 0.615 rs34363376 chr7:65939536 T/C cg12463550 chr7:65579703 CRCP 0.65 5.81 0.31 1.47e-8 Diabetic kidney disease; CRC cis rs7618915 0.501 rs3852066 chr3:52621839 C/T cg10802521 chr3:52805072 NEK4 -0.58 -9.07 -0.45 1.13e-17 Bipolar disorder; CRC cis rs9549367 0.713 rs3024747 chr13:113821787 C/G cg18105134 chr13:113819100 PROZ -0.86 -13.34 -0.59 9.22e-33 Platelet distribution width; CRC cis rs11792861 0.888 rs11794648 chr9:111829792 C/T cg05043794 chr9:111880884 C9orf5 -0.35 -6.27 -0.33 1.15e-9 Menarche (age at onset); CRC cis rs9875589 0.509 rs1488375 chr3:14061563 G/A cg14375111 chr3:14165186 TMEM43;CHCHD4 0.41 6.21 0.32 1.55e-9 Ovarian reserve; CRC cis rs4132509 1.000 rs10927078 chr1:243983830 C/T cg21452805 chr1:244014465 NA 0.53 6.26 0.33 1.19e-9 RR interval (heart rate); CRC cis rs11148252 0.508 rs11148260 chr13:53162643 A/C cg02158880 chr13:53174818 NA 0.6 9.77 0.47 5.91e-20 Lewy body disease; CRC cis rs2243480 0.901 rs13237344 chr7:66022256 T/A cg25985355 chr7:65971099 NA -0.53 -6.08 -0.32 3.36e-9 Diabetic kidney disease; CRC cis rs6577655 0.517 rs2241893 chr8:135586659 C/T cg17885191 chr8:135476712 NA 0.5 5.77 0.3 1.84e-8 Visceral adipose tissue/subcutaneous adipose tissue ratio; CRC cis rs12586317 0.547 rs45531432 chr14:35484423 C/T cg05294307 chr14:35346193 BAZ1A -0.7 -7.7 -0.39 1.65e-13 Psoriasis; CRC cis rs1568889 1.000 rs34140872 chr11:28335872 A/C cg06544937 chr11:28130018 METT5D1;KIF18A 0.79 11.01 0.52 3.15e-24 Bipolar disorder; CRC trans rs2303319 0.504 rs62189055 chr2:162625749 C/A cg08132177 chr1:856685 NA -0.68 -6.0 -0.31 5.29e-9 Cognitive function; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg11220133 chr8:48873533 MCM4;PRKDC 0.36 6.05 0.32 3.99e-9 Liver disease severity in Alagille syndrome; CRC cis rs6912958 0.712 rs6930600 chr6:88349787 G/A cg12350822 chr6:88032061 C6orf162;GJB7 -0.32 -5.98 -0.31 5.68e-9 Monocyte percentage of white cells; CRC cis rs2153535 0.580 rs1414340 chr6:8491139 G/A cg07606381 chr6:8435919 SLC35B3 0.67 10.78 0.51 2.07e-23 Motion sickness; CRC cis rs747650 0.504 rs7124648 chr11:47044249 T/C cg19486271 chr11:47235900 DDB2 -0.44 -5.9 -0.31 9.01e-9 Acne (severe); CRC trans rs875971 0.660 rs2191268 chr7:66110224 C/T cg26784276 chr17:7142991 PHF23 -0.41 -6.44 -0.33 4.36e-10 Aortic root size; CRC cis rs9311474 1.000 rs9311474 chr3:52338852 T/C cg15147215 chr3:52552868 STAB1 -0.66 -11.52 -0.54 5.15e-26 Electroencephalogram traits; CRC cis rs5758511 0.680 rs1001586 chr22:42670293 G/T cg00645731 chr22:42541494 CYP2D7P1 0.63 9.65 0.47 1.44e-19 Birth weight; CRC cis rs743757 1.000 rs743857 chr3:50493550 T/C cg08207895 chr3:50388901 TUSC4;CYB561D2 0.44 6.43 0.33 4.41e-10 Diastolic blood pressure; CRC cis rs2836974 0.623 rs7280326 chr21:40700408 A/G cg22974920 chr21:40686053 BRWD1 -0.42 -5.65 -0.3 3.5e-8 Cognitive function; CRC cis rs7219014 1 rs7219014 chr17:37624790 A/G cg15445000 chr17:37608096 MED1 0.41 8.77 0.44 9.81e-17 Urinary metabolites; CRC cis rs56399783 0.901 rs757788 chr7:2836433 A/G cg19731401 chr7:2775893 GNA12 0.61 6.54 0.34 2.35e-10 Childhood ear infection; CRC cis rs17021463 0.673 rs17565759 chr4:95280763 C/T cg11021082 chr4:95130006 SMARCAD1 0.44 6.32 0.33 8.62e-10 Testicular germ cell tumor; CRC cis rs910316 0.763 rs735452 chr14:75497984 A/G cg08847533 chr14:75593920 NEK9 -0.9 -16.18 -0.67 9.81e-44 Height; CRC cis rs6598955 0.724 rs869683 chr1:26570993 T/A cg04990556 chr1:26633338 UBXN11 -0.78 -13.38 -0.59 6.93e-33 Obesity-related traits; CRC trans rs7615952 0.599 rs67566088 chr3:125768973 C/A cg07211511 chr3:129823064 LOC729375 -0.72 -9.65 -0.47 1.42e-19 Blood pressure (smoking interaction); CRC cis rs7208859 0.673 rs11080138 chr17:29224542 A/G cg13385521 chr17:29058706 SUZ12P 0.69 7.93 0.4 3.48e-14 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs477895 1.000 rs7938380 chr11:64034866 G/A cg18225595 chr11:63971243 STIP1 0.58 6.62 0.34 1.46e-10 Mean platelet volume; CRC cis rs853679 1.000 rs853676 chr6:28299687 C/T cg15786705 chr6:28176104 NA 0.58 6.03 0.32 4.51e-9 Depression; CRC cis rs875971 0.619 rs12533585 chr7:65984605 G/C cg18876405 chr7:65276391 NA 0.61 10.95 0.52 5.42e-24 Aortic root size; CRC cis rs12348691 0.503 rs10983975 chr9:100614188 A/C cg13688889 chr9:100608707 NA -0.47 -6.05 -0.32 3.87e-9 Alopecia areata; CRC cis rs12549902 1.000 rs12550613 chr8:41510260 G/C cg17182837 chr8:41585554 ANK1 -0.4 -6.21 -0.32 1.63e-9 Corrected insulin response;Corrected insulin response adjusted for insulin sensitivity index;Insulin levels adjusted for BMI;Type 2 diabetes; CRC cis rs3091242 0.933 rs12402120 chr1:25751632 C/T cg23205692 chr1:25664452 TMEM50A 0.42 6.05 0.32 3.94e-9 Erythrocyte sedimentation rate; CRC cis rs56235845 0.694 rs6860069 chr5:176755841 C/T cg17261708 chr5:176794207 RGS14 0.43 6.83 0.35 3.99e-11 Hemoglobin concentration;Hematocrit; CRC cis rs873917 0.620 rs784595 chr1:40135017 C/T cg06209491 chr1:40138402 NT5C1A -0.48 -7.75 -0.39 1.18e-13 Amyotrophic lateral sclerosis; CRC cis rs1448094 0.511 rs34885805 chr12:86155180 A/T cg18827107 chr12:86230957 RASSF9 -0.41 -6.18 -0.32 1.89e-9 Major depressive disorder; CRC cis rs870825 0.616 rs7659201 chr4:185632013 G/A cg04058563 chr4:185651563 MLF1IP 0.72 9.26 0.45 2.73e-18 Blood protein levels; CRC cis rs8077889 0.956 rs116979403 chr17:41849105 G/A cg25876840 chr17:41920477 NA 0.53 7.14 0.37 5.85e-12 Triglycerides; CRC cis rs10927875 0.541 rs1048334 chr1:16340761 T/C cg10494257 chr1:16342123 HSPB7 0.45 6.24 0.33 1.33e-9 Dilated cardiomyopathy; CRC cis rs832540 0.966 rs252925 chr5:56203773 G/A cg24531977 chr5:56204891 C5orf35 -0.46 -6.97 -0.36 1.74e-11 Coronary artery disease; CRC cis rs12477438 0.520 rs4340581 chr2:99725025 C/T cg14399236 chr2:99771627 LIPT1;TSGA10 0.83 14.58 0.63 1.76e-37 Chronic sinus infection; CRC cis rs2228479 1.000 rs11642267 chr16:89957635 T/C cg06656553 chr16:89960601 TCF25 -0.69 -6.06 -0.32 3.75e-9 Skin colour saturation; CRC cis rs9393692 0.537 rs2393594 chr6:26316289 G/C cg13736514 chr6:26305472 NA -0.45 -7.24 -0.37 3.18e-12 Educational attainment; CRC cis rs806215 1.000 rs712697 chr7:127247132 T/A cg25922125 chr7:127225783 GCC1 0.58 6.37 0.33 6.52e-10 Type 2 diabetes; CRC cis rs7851660 0.527 rs7870540 chr9:100573925 T/C cg13688889 chr9:100608707 NA -0.4 -5.73 -0.3 2.31e-8 Strep throat; CRC cis rs9443645 0.901 rs9352670 chr6:79584433 A/G cg05283184 chr6:79620031 NA -0.58 -9.34 -0.46 1.48e-18 Intelligence (multi-trait analysis); CRC cis rs35883536 0.588 rs72977389 chr1:101107053 A/C cg14515779 chr1:101123966 NA -0.33 -5.88 -0.31 9.88e-9 Monocyte count; CRC cis rs875971 0.522 rs10807697 chr7:65416170 A/G cg00343986 chr7:65444356 GUSB 0.57 8.6 0.43 3.29e-16 Aortic root size; CRC cis rs514406 0.861 rs4926577 chr1:53226788 C/A cg27535305 chr1:53392650 SCP2 0.38 6.97 0.36 1.77e-11 Monocyte count; CRC cis rs1577917 1.000 rs117907570 chr6:86601283 T/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.51 -6.91 -0.36 2.44e-11 Response to antipsychotic treatment; CRC cis rs7615952 0.599 rs7631268 chr3:125755664 T/A cg04553112 chr3:125709451 NA -0.51 -5.71 -0.3 2.5e-8 Blood pressure (smoking interaction); CRC cis rs28386778 0.897 rs1062790 chr17:61896455 A/G cg23090583 chr17:61904693 PSMC5;FTSJ3 1.05 20.68 0.75 1.83e-61 Prudent dietary pattern; CRC cis rs2976388 0.565 rs2572905 chr8:143797104 C/T cg24046110 chr8:143859143 LYNX1 0.46 8.05 0.41 1.57e-14 Urinary tract infection frequency; CRC trans rs10983614 1.000 rs7867776 chr9:120072627 A/G cg11686940 chr15:31664433 KLF13 0.46 6.51 0.34 2.83e-10 Survival in pancreatic cancer; CRC cis rs11583043 0.874 rs6577219 chr1:101415707 A/G cg16556008 chr1:101360663 SLC30A7;EXTL2 0.56 7.69 0.39 1.76e-13 Ulcerative colitis;Inflammatory bowel disease; CRC cis rs28655083 1.000 rs11864710 chr16:77075284 A/T cg01753188 chr16:77233325 SYCE1L;MON1B -0.53 -7.42 -0.38 1.02e-12 Lobe attachment (rater-scored or self-reported); CRC cis rs2404602 0.684 rs11854850 chr15:76844571 C/T cg23625390 chr15:77176239 SCAPER -0.9 -15.13 -0.64 1.27e-39 Blood metabolite levels; CRC cis rs13191362 1.000 rs13210756 chr6:163009030 T/A cg06582575 chr6:163149167 PACRG;PARK2 0.71 10.22 0.49 1.72e-21 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs875971 0.825 rs1000464 chr7:65777909 G/C cg18876405 chr7:65276391 NA -0.51 -8.5 -0.42 6.71e-16 Aortic root size; CRC cis rs853679 0.517 rs2273564 chr6:28057594 A/T cg25164649 chr6:28176230 NA 0.75 9.36 0.46 1.32e-18 Depression; CRC cis rs9322193 0.923 rs10747275 chr6:149943918 C/T cg07701084 chr6:150067640 NUP43 0.52 7.7 0.39 1.66e-13 Lung cancer; CRC cis rs10782582 0.593 rs74090712 chr1:76189098 A/G cg03433033 chr1:76189801 ACADM -0.45 -6.61 -0.34 1.56e-10 Daytime sleep phenotypes; CRC cis rs17818399 0.547 rs4952831 chr2:46761181 G/A cg26688816 chr2:46740690 ATP6V1E2 -0.51 -6.4 -0.33 5.2e-10 Height; CRC cis rs12887734 0.546 rs4900597 chr14:104266664 A/G cg01849466 chr14:104193079 ZFYVE21 0.44 6.88 0.35 3.02e-11 Schizophrenia;Autism spectrum disorder or schizophrenia; CRC cis rs7772486 0.790 rs2243665 chr6:146208120 A/C cg13319975 chr6:146136371 FBXO30 -0.41 -6.29 -0.33 9.86e-10 Lobe attachment (rater-scored or self-reported); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg16235707 chr5:75698461 IQGAP2 0.41 6.01 0.31 4.87e-9 Intelligence (multi-trait analysis); CRC cis rs8062405 1.000 rs7198606 chr16:28875122 T/G cg08761264 chr16:28874980 SH2B1 -0.44 -5.83 -0.31 1.33e-8 Cognitive ability (multi-trait analysis);Cognitive ability; CRC cis rs2274273 0.870 rs61210954 chr14:55765402 T/C cg23234261 chr14:55582407 NA -0.28 -5.66 -0.3 3.22e-8 Protein biomarker; CRC cis rs10504229 0.906 rs112793785 chr8:58190537 T/C cg02725872 chr8:58115012 NA -0.38 -6.42 -0.33 4.72e-10 Developmental language disorder (linguistic errors); CRC cis rs9457247 0.565 rs12193698 chr6:167512073 C/A cg07741184 chr6:167504864 NA 0.48 7.94 0.4 3.15e-14 Crohn's disease; CRC cis rs4974559 0.895 rs57037487 chr4:1386652 A/G cg02980000 chr4:1222292 CTBP1 0.59 7.94 0.4 3.23e-14 Systolic blood pressure; CRC cis rs2130392 0.926 rs1107907 chr4:185620108 G/T cg04058563 chr4:185651563 MLF1IP 0.41 6.04 0.32 4.26e-9 Kawasaki disease; CRC cis rs11971779 0.648 rs4732367 chr7:139028102 A/C cg07862535 chr7:139043722 LUC7L2 0.55 7.14 0.37 5.99e-12 Diisocyanate-induced asthma; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg13541861 chr19:507806 C19orf20 0.45 6.16 0.32 2.09e-9 Anxiety disorder; CRC cis rs6502050 0.835 rs3935128 chr17:80113414 T/C cg22110888 chr17:80059540 CCDC57 0.4 6.44 0.33 4.17e-10 Life satisfaction; CRC cis rs6432018 0.927 rs6432023 chr2:9736874 C/T cg12832956 chr2:9616023 IAH1 -0.37 -5.62 -0.3 4.17e-8 Heart rate variability traits; CRC cis rs1799949 0.965 rs33988650 chr17:41287880 A/G cg23758822 chr17:41437982 NA 0.79 13.45 0.6 3.6e-33 Menopause (age at onset); CRC cis rs8016982 0.698 rs12590764 chr14:81704417 G/A cg01989461 chr14:81687754 GTF2A1 0.55 8.68 0.43 1.84e-16 Schizophrenia; CRC cis rs7208859 0.673 rs216409 chr17:28906269 C/T cg13385521 chr17:29058706 SUZ12P -0.45 -5.97 -0.31 5.98e-9 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs7843479 0.509 rs3758156 chr8:21770796 A/G cg17168535 chr8:21777572 XPO7 0.6 10.04 0.48 7.42e-21 Mean corpuscular volume; CRC cis rs9649213 0.574 rs7802560 chr7:97903806 A/G cg21770322 chr7:97807741 LMTK2 -0.52 -8.9 -0.44 3.74e-17 Prostate cancer (SNP x SNP interaction); CRC trans rs7618501 0.602 rs6780731 chr3:50017478 A/G cg21659725 chr3:3221576 CRBN 0.61 9.47 0.46 5.81e-19 Intelligence (multi-trait analysis); CRC cis rs999943 0.810 rs62407648 chr6:33622436 C/G cg14003231 chr6:33640908 ITPR3 0.96 16.91 0.68 1.28e-46 Obesity (extreme); CRC cis rs2070488 0.965 rs2051215 chr3:38560345 A/G cg01465620 chr3:38496096 LOC100128640;ACVR2B -0.87 -16.32 -0.67 2.71e-44 Electrocardiographic conduction measures; CRC cis rs7552404 0.628 rs5745442 chr1:76342858 T/G cg10523679 chr1:76189770 ACADM 0.75 8.9 0.44 3.94e-17 Blood metabolite levels;Acylcarnitine levels; CRC cis rs12135062 0.687 rs6685614 chr1:3108517 C/T cg25382214 chr1:3105252 PRDM16 0.41 7.1 0.36 7.88e-12 Migraine; CRC cis rs3771570 1.000 rs60604866 chr2:242352257 A/G cg21155796 chr2:242212141 HDLBP 0.66 7.11 0.36 7.22e-12 Prostate cancer; CRC trans rs11722228 0.539 rs62287552 chr4:10153197 C/T cg26043149 chr18:55253948 FECH 1.15 19.01 0.72 6.52e-55 Gout;Urate levels;Serum uric acid levels; CRC cis rs61160187 0.556 rs4647052 chr5:60235483 C/T cg16298547 chr5:60138761 ELOVL7 -0.28 -5.91 -0.31 8.4e-9 Educational attainment (years of education);Educational attainment (college completion); CRC cis rs477895 0.653 rs34089806 chr11:63887987 C/T cg18225595 chr11:63971243 STIP1 0.55 7.11 0.36 7.41e-12 Mean platelet volume; CRC cis rs67311347 1.000 rs9842564 chr3:40405810 A/G cg24209194 chr3:40518798 ZNF619 -0.44 -6.9 -0.36 2.63e-11 Renal cell carcinoma; CRC cis rs6502050 0.835 rs8077772 chr17:80117220 A/G cg22110888 chr17:80059540 CCDC57 -0.4 -6.32 -0.33 8.69e-10 Life satisfaction; CRC cis rs11785400 0.963 rs4579507 chr8:143733663 C/G cg24634471 chr8:143751801 JRK 0.53 7.58 0.39 3.48e-13 Schizophrenia; CRC cis rs9322193 0.923 rs9322204 chr6:149957183 A/C cg07701084 chr6:150067640 NUP43 0.53 7.84 0.4 6.14e-14 Lung cancer; CRC cis rs870825 0.616 rs28582728 chr4:185646920 C/T cg04058563 chr4:185651563 MLF1IP 0.72 9.3 0.46 2.04e-18 Blood protein levels; CRC cis rs561341 0.882 rs16967101 chr17:30377162 A/G cg12193833 chr17:30244370 NA -0.6 -7.88 -0.4 4.82e-14 Hip circumference adjusted for BMI; CRC cis rs1552244 1.000 rs6789156 chr3:10124120 C/T cg08888203 chr3:10149979 C3orf24 0.68 9.31 0.46 1.94e-18 Alzheimer's disease; CRC trans rs2840044 1.000 rs8073935 chr17:33985849 C/T cg19694781 chr19:47549865 TMEM160 -0.47 -7.35 -0.38 1.54e-12 Response to radiotherapy in cancer (late toxicity); CRC cis rs7692995 1.000 rs6449353 chr4:18033488 T/C cg08925142 chr4:18023851 LCORL -0.53 -5.98 -0.31 5.94e-9 Height; CRC cis rs208520 0.754 rs1100989 chr6:66880532 G/A cg07460842 chr6:66804631 NA -1.05 -14.47 -0.62 4.53e-37 Exhaled nitric oxide output; CRC cis rs9513627 0.573 rs12431100 chr13:100184918 C/G cg15490075 chr13:100150979 NA -0.52 -6.34 -0.33 7.73e-10 Obesity-related traits; CRC trans rs1455244 0.700 rs7229302 chr18:11508904 G/T cg05141026 chr8:145064874 GRINA 0.42 6.39 0.33 5.59e-10 Schizophrenia; CRC cis rs6940638 0.513 rs4424065 chr6:27036456 C/T cg12292205 chr6:26970375 C6orf41 -0.5 -8.24 -0.41 4.04e-15 Intelligence (multi-trait analysis); CRC cis rs2404602 0.716 rs4079681 chr15:76695230 G/A cg22467129 chr15:76604101 ETFA -0.44 -7.4 -0.38 1.18e-12 Blood metabolite levels; CRC cis rs12142240 0.698 rs6683192 chr1:46830257 C/T cg14993813 chr1:46806288 NSUN4 -0.49 -6.26 -0.33 1.21e-9 Menopause (age at onset); CRC cis rs7487075 0.754 rs10880962 chr12:46773444 C/G cg22049899 chr12:47219821 SLC38A4 0.34 6.82 0.35 4.46e-11 Itch intensity from mosquito bite; CRC cis rs2404602 0.692 rs56193230 chr15:76934472 C/T cg23625390 chr15:77176239 SCAPER 0.48 6.92 0.36 2.34e-11 Blood metabolite levels; CRC cis rs6495122 0.618 rs4886413 chr15:75262310 G/C cg05627522 chr15:75251581 NA 0.5 7.6 0.39 3.04e-13 Caffeine consumption;Diastolic blood pressure;Coffee consumption; CRC cis rs6502050 0.777 rs4625783 chr17:80086395 T/C cg13198984 chr17:80129470 CCDC57 -0.48 -8.55 -0.43 4.57e-16 Life satisfaction; CRC cis rs9902453 0.817 rs2321333 chr17:28140857 A/T cg26525008 chr17:28256777 EFCAB5;SSH2 0.73 12.21 0.56 1.56e-28 Coffee consumption (cups per day); CRC cis rs12541635 0.966 rs4734128 chr8:107026913 G/A cg10147462 chr8:107024639 NA 0.46 7.64 0.39 2.39e-13 Age of smoking initiation; CRC cis rs2120019 1.000 rs2415253 chr15:75375699 A/G cg17294928 chr15:75287854 SCAMP5 -0.73 -10.74 -0.51 2.87e-23 Blood trace element (Zn levels); CRC cis rs9457247 0.765 rs9457259 chr6:167444281 C/T cg07741184 chr6:167504864 NA 0.39 6.75 0.35 6.7e-11 Crohn's disease; CRC cis rs10504229 1.000 rs72650887 chr8:58177343 G/A cg01721255 chr8:58191610 C8orf71 0.5 6.21 0.32 1.62e-9 Developmental language disorder (linguistic errors); CRC cis rs45544231 0.544 rs1123428 chr16:52577835 A/T cg09051775 chr16:52580266 TOX3 0.4 6.42 0.33 4.78e-10 Restless legs syndrome; CRC cis rs514406 0.644 rs4926928 chr1:53210163 G/T cg24675658 chr1:53192096 ZYG11B -0.65 -9.89 -0.48 2.34e-20 Monocyte count; CRC cis rs597539 0.552 rs10896384 chr11:68720011 A/G cg21963583 chr11:68658836 MRPL21 -0.51 -9.13 -0.45 7.36e-18 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs6543140 0.964 rs11903551 chr2:103084181 C/G cg09003973 chr2:102972529 NA 0.41 5.86 0.31 1.12e-8 Blood protein levels; CRC cis rs17253792 0.545 rs12879705 chr14:56017684 C/G cg01858014 chr14:56050164 KTN1 -0.86 -6.64 -0.34 1.27e-10 Putamen volume; CRC cis rs3806843 1.000 rs3756342 chr5:140165624 G/A cg16607685 chr5:140181889 PCDHA2;PCDHA1;PCDHA3 -0.26 -5.92 -0.31 8.06e-9 Depressive symptoms (multi-trait analysis); CRC cis rs11098499 0.866 rs12374352 chr4:120281977 C/T cg24375607 chr4:120327624 NA 0.48 7.48 0.38 6.72e-13 Corneal astigmatism; CRC cis rs4730250 0.707 rs61014091 chr7:106810107 A/C cg02696742 chr7:106810147 HBP1 -0.66 -7.41 -0.38 1.06e-12 Osteoarthritis; CRC cis rs35110281 0.686 rs162399 chr21:44950020 G/A cg01579765 chr21:45077557 HSF2BP -0.36 -6.74 -0.35 7.12e-11 Mean corpuscular volume; CRC cis rs713587 0.520 rs530951 chr2:25307005 C/T cg22495460 chr2:25135724 ADCY3 0.44 6.63 0.34 1.39e-10 Body mass index in non-asthmatics; CRC trans rs9291683 0.527 rs3822241 chr4:10094931 G/A cg26043149 chr18:55253948 FECH -0.58 -8.67 -0.43 1.96e-16 Bone mineral density; CRC cis rs1971762 0.583 rs1527068 chr12:54088688 A/G cg06632207 chr12:54070931 ATP5G2 0.39 6.72 0.35 8.1e-11 Height; CRC cis rs11764590 0.671 rs56226325 chr7:2078981 C/T cg21155852 chr7:2048760 MAD1L1 -0.48 -6.31 -0.33 8.82e-10 Neuroticism; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg16956456 chr5:172483378 C5orf41 0.43 6.19 0.32 1.8e-9 Response to antipsychotic treatment; CRC cis rs2228479 0.850 rs11649100 chr16:89798179 A/G cg06656553 chr16:89960601 TCF25 -0.68 -5.66 -0.3 3.31e-8 Skin colour saturation; CRC trans rs9329221 0.638 rs12543645 chr8:10246325 C/G cg06636001 chr8:8085503 FLJ10661 -0.49 -7.43 -0.38 9.31e-13 Neuroticism; CRC cis rs4727027 0.933 rs12540094 chr7:148847178 A/G cg12479418 chr7:148823350 ZNF425;ZNF398 -0.43 -5.84 -0.31 1.29e-8 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC cis rs6570726 0.738 rs4495284 chr6:145916617 T/A cg05347473 chr6:146136440 FBXO30 0.4 6.04 0.32 4.18e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs10504229 0.679 rs6995378 chr8:58113933 C/T cg24829409 chr8:58192753 C8orf71 -0.54 -7.88 -0.4 4.9e-14 Developmental language disorder (linguistic errors); CRC cis rs7124681 0.584 rs7950674 chr11:47871017 T/C cg20307385 chr11:47447363 PSMC3 0.46 6.66 0.34 1.18e-10 Body mass index (joint analysis main effects and physical activity interaction);Body mass index;Body mass index in physically active individuals; CRC cis rs2430307 0.556 rs3930019 chr7:76541610 C/T cg15770687 chr7:76625569 PMS2L11 0.68 7.72 0.39 1.46e-13 Body mass index (joint analysis main effects and physical activity interaction);Body mass index;Body mass index in physically active individuals; CRC cis rs3087591 0.960 rs2905787 chr17:29482381 G/A cg24425628 chr17:29625626 OMG;NF1 0.79 12.98 0.58 2.2e-31 Hip circumference; CRC cis rs77861329 0.702 rs12496447 chr3:52103787 T/C cg08692210 chr3:52188851 WDR51A 0.54 6.3 0.33 9.46e-10 Macrophage inflammatory protein 1b levels; CRC cis rs10256972 0.900 rs7812072 chr7:1053862 A/G cg07930192 chr7:1003750 NA 0.45 6.92 0.36 2.31e-11 Longevity;Endometriosis; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg23470272 chr19:14640395 TECR;MIR639 0.4 6.36 0.33 6.69e-10 Liver disease severity in Alagille syndrome; CRC cis rs17023223 0.509 rs56195272 chr1:119713997 A/T cg05756136 chr1:119680316 WARS2 -0.52 -7.14 -0.37 6e-12 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for BMI in active individuals; CRC cis rs17433780 0.504 rs7525985 chr1:89460948 C/T cg09516651 chr1:89888402 LOC400759 0.36 5.77 0.3 1.82e-8 Carotid intima media thickness; CRC cis rs9549367 0.713 rs3024769 chr13:113825601 A/C cg18105134 chr13:113819100 PROZ 0.83 12.83 0.58 8.21e-31 Platelet distribution width; CRC cis rs1023500 0.505 rs134901 chr22:42683520 C/T cg04733989 chr22:42467013 NAGA 0.43 6.22 0.32 1.51e-9 Schizophrenia; CRC cis rs7827545 1.000 rs7463007 chr8:135567143 C/T cg13086574 chr8:135490821 ZFAT -0.36 -6.33 -0.33 7.81e-10 Hypertension (SNP x SNP interaction); CRC cis rs4909189 1.000 rs12698214 chr7:158136204 T/G cg24154853 chr7:158122151 PTPRN2 0.51 7.07 0.36 9.19e-12 Response to amphetamines; CRC cis rs7715806 0.500 rs2307112 chr5:75003413 A/C cg19683494 chr5:74908142 NA 0.51 5.71 0.3 2.51e-8 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs6681460 0.966 rs4655646 chr1:67094336 G/A cg02459107 chr1:67143332 SGIP1 0.44 7.14 0.37 6e-12 Presence of antiphospholipid antibodies; CRC cis rs6964587 1.000 rs10274756 chr7:91740796 G/A cg17063962 chr7:91808500 NA 0.81 14.35 0.62 1.37e-36 Breast cancer; CRC cis rs4900538 0.855 rs9788420 chr14:102839338 A/G cg18135206 chr14:102964638 TECPR2 -1.0 -18.02 -0.7 5.28e-51 Mean corpuscular volume;Mean corpuscular hemoglobin; CRC cis rs4363385 1.000 rs310124 chr1:153020275 C/T cg25856811 chr1:152973957 SPRR3 -0.22 -5.7 -0.3 2.67e-8 Inflammatory skin disease; CRC trans rs7618501 0.933 rs3811695 chr3:49761613 C/T cg21665057 chr3:196295764 WDR53;FBXO45 -0.86 -15.76 -0.66 4.38e-42 Intelligence (multi-trait analysis); CRC cis rs1552244 0.810 rs7612908 chr3:10089148 A/G cg18598329 chr3:10140678 FANCD2;C3orf24 -0.87 -11.82 -0.55 4.24e-27 Alzheimer's disease; CRC cis rs9488822 0.702 rs10872141 chr6:116323246 C/A cg05304507 chr6:116381966 FRK 0.3 8.25 0.41 3.81e-15 Cholesterol, total;LDL cholesterol; CRC cis rs644799 0.965 rs1944080 chr11:95503636 T/C cg25622487 chr11:95524042 FAM76B;CEP57 0.75 11.51 0.54 5.3e-26 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs6831352 0.918 rs17218602 chr4:100061073 A/G cg12011299 chr4:100065546 ADH4 -0.5 -9.53 -0.47 3.62e-19 Alcohol dependence; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg05296608 chr10:134537282 INPP5A -0.39 -6.36 -0.33 6.93e-10 Liver disease severity in Alagille syndrome; CRC cis rs6500395 1.000 rs7185899 chr16:48714101 A/G cg04672837 chr16:48644449 N4BP1 -0.45 -6.63 -0.34 1.38e-10 Response to tocilizumab in rheumatoid arthritis; CRC cis rs7089973 0.872 rs7094072 chr10:116627160 T/G cg23260525 chr10:116636907 FAM160B1 0.31 6.75 0.35 6.66e-11 Bipolar disorder or attention deficit hyperactivity disorder; CRC cis rs6460942 0.915 rs17324858 chr7:12305792 G/T cg20607287 chr7:12443886 VWDE -0.44 -5.88 -0.31 1.03e-8 Coronary artery disease; CRC cis rs2228479 0.867 rs11642451 chr16:89958127 T/C cg19635926 chr16:89946313 TCF25 0.69 6.92 0.36 2.41e-11 Skin colour saturation; CRC cis rs875971 0.660 rs2191268 chr7:66110224 C/T cg24972876 chr7:65420302 NA 0.38 6.56 0.34 2.05e-10 Aortic root size; CRC cis rs7091068 0.518 rs913045 chr10:95431535 C/T cg20715218 chr10:95462985 C10orf4 0.54 7.4 0.38 1.14e-12 Urinary tract infection frequency; CRC cis rs2979489 0.891 rs17626867 chr8:30311177 G/T cg26383811 chr8:30366931 RBPMS -0.7 -9.85 -0.48 3.13e-20 Mean corpuscular hemoglobin;Plateletcrit;Neutrophil count;Granulocyte count;Sum basophil neutrophil counts;Mean corpuscular volume;Myeloid white cell count;Sum neutrophil eosinophil counts; CRC cis rs11690935 0.959 rs12692974 chr2:172663256 T/C cg13550731 chr2:172543902 DYNC1I2 -1.04 -17.65 -0.7 1.53e-49 Schizophrenia; CRC cis rs9911578 0.900 rs7214335 chr17:57158840 G/A cg05425664 chr17:57184151 TRIM37 -0.47 -7.45 -0.38 8.36e-13 Intelligence (multi-trait analysis); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg04621255 chr9:131581398 ENDOG 0.44 6.07 0.32 3.57e-9 Response to antipsychotic treatment; CRC cis rs9322193 0.923 rs9322196 chr6:149940781 T/G cg13206674 chr6:150067644 NUP43 0.63 9.49 0.46 4.71e-19 Lung cancer; CRC cis rs10464366 0.957 rs11765705 chr7:39106942 G/T cg18850127 chr7:39170497 POU6F2 0.5 6.43 0.33 4.42e-10 IgG glycosylation; CRC cis rs4664308 1.000 rs2175416 chr2:160904021 G/A cg03641300 chr2:160917029 PLA2R1 -0.76 -12.77 -0.58 1.35e-30 Idiopathic membranous nephropathy; CRC cis rs4665809 1.000 rs11126375 chr2:26344787 G/A cg27170947 chr2:26402098 FAM59B -0.46 -6.1 -0.32 2.93e-9 Gut microbiome composition (summer); CRC cis rs875971 0.545 rs2460427 chr7:65619205 T/C cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.6 -7.81 -0.4 7.9e-14 Aortic root size; CRC trans rs8073060 0.586 rs2523116 chr17:34025460 T/C cg19694781 chr19:47549865 TMEM160 -1.08 -14.86 -0.63 1.46e-38 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; CRC cis rs6952808 0.689 rs1107591 chr7:2041638 G/A cg02951883 chr7:2050386 MAD1L1 -0.77 -12.71 -0.57 2.21e-30 Bipolar disorder and schizophrenia; CRC cis rs921968 0.643 rs1516086 chr2:219431535 C/T cg02176678 chr2:219576539 TTLL4 0.48 7.76 0.39 1.09e-13 Mean corpuscular hemoglobin concentration; CRC trans rs3780486 0.846 rs10813950 chr9:33127640 A/G cg20290983 chr6:43655470 MRPS18A -1.2 -24.93 -0.81 8.44e-78 IgG glycosylation; CRC cis rs1023500 0.573 rs2269524 chr22:42475703 T/G cg15557168 chr22:42548783 NA 0.38 6.43 0.33 4.54e-10 Schizophrenia; CRC trans rs8073060 0.544 rs225246 chr17:33944773 T/C cg19694781 chr19:47549865 TMEM160 -1.04 -14.44 -0.62 6.2e-37 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; CRC cis rs1799949 1.000 rs11653253 chr17:41182662 G/A cg19454999 chr17:41278357 BRCA1;NBR2 0.53 7.99 0.4 2.31e-14 Menopause (age at onset); CRC cis rs727563 0.635 rs5751149 chr22:42139501 A/G cg06481639 chr22:41940642 POLR3H 0.55 6.19 0.32 1.82e-9 Crohn's disease;Inflammatory bowel disease; CRC cis rs6964587 1.000 rs2237568 chr7:91622676 G/A cg17063962 chr7:91808500 NA 0.81 14.19 0.62 5.62e-36 Breast cancer; CRC cis rs2735413 0.918 rs11150037 chr16:78075774 A/G cg04733911 chr16:78082701 NA -0.43 -7.11 -0.36 7.29e-12 Systolic blood pressure (alcohol consumption interaction); CRC cis rs9611565 0.649 rs202655 chr22:41841564 G/C cg03806693 chr22:41940476 POLR3H 0.95 12.69 0.57 2.73e-30 Vitiligo; CRC cis rs9611565 0.592 rs12484467 chr22:41957610 T/C cg06481639 chr22:41940642 POLR3H -0.54 -6.09 -0.32 3.15e-9 Vitiligo; CRC cis rs73206853 0.563 rs9706102 chr12:111185391 A/G cg12870014 chr12:110450643 ANKRD13A 0.73 8.56 0.43 4.32e-16 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC cis rs1150668 0.835 rs1233696 chr6:28143010 T/C cg23161317 chr6:28129485 ZNF389 0.39 5.85 0.31 1.17e-8 Pubertal anthropometrics; CRC trans rs11039798 0.511 rs7948129 chr11:48167828 G/A cg03929089 chr4:120376271 NA -0.7 -7.5 -0.38 5.82e-13 Axial length; CRC trans rs916888 0.821 rs199504 chr17:44861003 C/T cg22433210 chr17:43662623 NA -0.83 -9.06 -0.45 1.17e-17 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs4689388 0.926 rs4416547 chr4:6293967 G/A cg14416269 chr4:6271139 WFS1 0.4 6.62 0.34 1.43e-10 Type 2 diabetes and other traits;Type 2 diabetes; CRC cis rs6540559 1.000 rs7522250 chr1:209962539 T/C cg22029157 chr1:209979665 IRF6 0.69 9.91 0.48 1.91e-20 Cleft lip with or without cleft palate; CRC trans rs561341 0.941 rs112569713 chr17:30271738 C/T cg20587970 chr11:113659929 NA -1.18 -17.22 -0.69 7.98e-48 Hip circumference adjusted for BMI; CRC cis rs6662572 0.737 rs9429093 chr1:46555252 T/C cg03123370 chr1:45965343 CCDC163P;MMACHC 0.46 6.26 0.33 1.18e-9 Blood protein levels; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg04774914 chr12:50560863 LASS5 0.43 6.77 0.35 5.93e-11 Liver disease severity in Alagille syndrome; CRC cis rs4665809 0.590 rs7588328 chr2:26469788 G/A cg26119090 chr2:26468346 HADHA;HADHB 1.06 15.53 0.65 3.62e-41 Gut microbiome composition (summer); CRC cis rs4363385 0.755 rs1933382 chr1:153003295 G/T cg25856811 chr1:152973957 SPRR3 0.24 6.79 0.35 5.11e-11 Inflammatory skin disease; CRC cis rs6500395 1.000 rs1115758 chr16:48599609 T/C cg04672837 chr16:48644449 N4BP1 0.44 6.5 0.34 2.95e-10 Response to tocilizumab in rheumatoid arthritis; CRC trans rs208520 0.690 rs12198745 chr6:66722598 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.97 13.66 0.6 5.65e-34 Exhaled nitric oxide output; CRC cis rs72945132 0.882 rs7942613 chr11:70210675 C/T cg00319359 chr11:70116639 PPFIA1 0.59 6.61 0.34 1.6e-10 Coronary artery disease; CRC cis rs7605378 0.528 rs1704190 chr2:200760629 G/A cg17644776 chr2:200775616 C2orf69 0.49 7.91 0.4 4.07e-14 Osteoporosis; CRC cis rs801193 0.935 rs11772264 chr7:66176387 T/C cg05627663 chr7:65219948 SNORA22;CCT6P1 0.42 6.15 0.32 2.24e-9 Aortic root size; CRC cis rs9534288 0.797 rs4294711 chr13:46575557 C/T cg15192986 chr13:46630673 CPB2 -0.67 -9.79 -0.47 5.03e-20 Blood protein levels; CRC cis rs9611519 0.857 rs4820434 chr22:41637119 G/T cg06634786 chr22:41940651 POLR3H -0.5 -6.32 -0.33 8.73e-10 Neuroticism; CRC cis rs1862618 0.853 rs252909 chr5:56121131 T/C cg18230493 chr5:56204884 C5orf35 -0.71 -9.16 -0.45 5.88e-18 Initial pursuit acceleration; CRC cis rs2816062 0.813 rs6698315 chr1:18895806 A/G cg18795169 chr1:18902165 NA -0.92 -19.06 -0.72 4.49e-55 Urate levels in lean individuals; CRC cis rs4711350 0.734 rs9380379 chr6:33766131 A/G cg07979401 chr6:33739406 LEMD2 -0.44 -5.88 -0.31 9.87e-9 Schizophrenia; CRC cis rs747650 0.926 rs11039119 chr11:47201924 G/A cg19486271 chr11:47235900 DDB2 0.45 6.47 0.34 3.57e-10 Acne (severe); CRC cis rs4665809 0.838 rs6546749 chr2:26306288 T/C cg04944784 chr2:26401820 FAM59B -0.66 -8.1 -0.41 1.1e-14 Gut microbiome composition (summer); CRC cis rs8062405 0.722 rs3785354 chr16:28550667 C/T cg05139728 chr16:28306816 SBK1 -0.37 -5.98 -0.31 5.74e-9 Cognitive ability (multi-trait analysis);Cognitive ability; CRC cis rs17767392 0.881 rs7142343 chr14:72023489 T/C cg13720639 chr14:72061746 SIPA1L1 0.56 7.17 0.37 5.05e-12 Mitral valve prolapse; CRC cis rs7772486 0.875 rs6570736 chr6:146388320 C/T cg23711669 chr6:146136114 FBXO30 0.68 11.93 0.55 1.62e-27 Lobe attachment (rater-scored or self-reported); CRC cis rs7493 1.000 rs2068604 chr7:95041542 G/T cg01874867 chr7:94954059 PON1 -0.49 -6.2 -0.32 1.7e-9 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs9325144 0.560 rs11182979 chr12:38642562 C/A cg13010199 chr12:38710504 ALG10B -0.41 -5.99 -0.31 5.52e-9 Morning vs. evening chronotype; CRC cis rs921968 0.643 rs589967 chr2:219445165 T/C cg02176678 chr2:219576539 TTLL4 0.48 8.02 0.4 1.82e-14 Mean corpuscular hemoglobin concentration; CRC cis rs2404602 0.692 rs35999717 chr15:77193367 G/C cg23625390 chr15:77176239 SCAPER 0.47 6.58 0.34 1.83e-10 Blood metabolite levels; CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg19826439 chr1:226297528 NA 0.4 6.55 0.34 2.22e-10 Obesity-related traits; CRC cis rs250677 0.687 rs36046 chr5:148441257 A/C cg18129178 chr5:148520854 ABLIM3 -0.36 -5.7 -0.3 2.62e-8 Breast cancer; CRC cis rs2857891 0.697 rs1004754 chr11:6946248 T/C cg17084751 chr11:6953558 ZNF215 -0.51 -5.77 -0.3 1.86e-8 Response to cytadine analogues (cytosine arabinoside); CRC cis rs12188164 0.965 rs72717430 chr5:444502 T/C cg16322479 chr5:444228 EXOC3;C5orf55 0.5 8.06 0.41 1.43e-14 Cystic fibrosis severity; CRC cis rs4824093 0.610 rs3761496 chr22:50246466 T/C cg22709217 chr22:50311962 ALG12;CRELD2 -0.94 -8.27 -0.41 3.36e-15 Amyotrophic lateral sclerosis (sporadic); CRC cis rs9926296 0.533 rs7190823 chr16:89866043 A/G cg21285383 chr16:89894308 SPIRE2 0.38 6.72 0.35 8.22e-11 Vitiligo; CRC trans rs6550704 0.687 rs9865314 chr3:22634337 A/G cg17267835 chr6:161413433 MAP3K4 -0.4 -6.19 -0.32 1.76e-9 Daytime sleep phenotypes; CRC cis rs7613875 0.620 rs17657688 chr3:50033228 C/T cg24110177 chr3:50126178 RBM5 0.58 9.16 0.45 5.65e-18 Body mass index; CRC cis rs9291683 0.530 rs35908990 chr4:9976105 G/A cg11266682 chr4:10021025 SLC2A9 0.5 10.35 0.5 6.3e-22 Bone mineral density; CRC cis rs1008375 1.000 rs2286771 chr4:17643848 G/A cg04450456 chr4:17643702 FAM184B 0.41 6.72 0.35 8.23e-11 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs10256972 0.552 rs2960831 chr7:1201192 A/T cg23708337 chr7:1209742 NA 0.51 7.81 0.4 7.79e-14 Longevity;Endometriosis; CRC cis rs7113874 0.569 rs9300091 chr11:8588823 G/A cg17679104 chr11:8615758 STK33 -0.36 -6.08 -0.32 3.28e-9 Body mass index in physically active individuals;Body mass index (joint analysis main effects and physical activity interaction); CRC trans rs2243480 1.000 rs316321 chr7:65611613 G/A cg10756647 chr7:56101905 PSPH 0.77 7.88 0.4 4.91e-14 Diabetic kidney disease; CRC cis rs9309473 0.579 rs6728128 chr2:73595982 T/C cg20560298 chr2:73613845 ALMS1 -0.49 -6.83 -0.35 4.01e-11 Metabolite levels; CRC cis rs3106136 0.934 rs17376404 chr4:95224046 T/A cg11021082 chr4:95130006 SMARCAD1 -0.46 -7.15 -0.37 5.64e-12 Capecitabine sensitivity; CRC cis rs1218582 0.688 rs2135219 chr1:154857217 G/A cg16680214 chr1:154839983 KCNN3 -0.54 -9.7 -0.47 1.01e-19 Prostate cancer; CRC cis rs4660306 1.000 rs2077808 chr1:45988115 G/A cg03123370 chr1:45965343 CCDC163P;MMACHC -0.55 -7.81 -0.4 7.94e-14 Homocysteine levels; CRC cis rs3996993 0.809 rs6917325 chr6:52666273 A/G cg20803780 chr6:52668592 GSTA1 -0.37 -6.95 -0.36 1.97e-11 Hemoglobin concentration; CRC cis rs2721195 0.967 rs1480000 chr8:145702007 C/T cg17328964 chr8:145687451 CYHR1 0.63 10.89 0.51 8.69e-24 Age at first birth; CRC cis rs9926296 0.712 rs258319 chr16:89732024 A/T cg03605463 chr16:89740564 NA 0.59 8.99 0.44 1.95e-17 Vitiligo; CRC cis rs13108904 0.967 rs900027 chr4:1279360 G/A cg00684032 chr4:1343700 KIAA1530 0.48 6.99 0.36 1.5e-11 Obesity-related traits; CRC cis rs12580194 0.593 rs61957899 chr12:55731971 C/T cg19537932 chr12:55886519 OR6C68 -0.64 -8.33 -0.42 2.2e-15 Cancer; CRC cis rs2952156 0.834 rs903503 chr17:37829571 C/A cg20243544 chr17:37824526 PNMT 0.57 9.04 0.45 1.33e-17 Asthma; CRC cis rs6951245 1.000 rs884977 chr7:1066410 T/C cg03188948 chr7:1209495 NA 0.54 6.56 0.34 2.15e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs4730250 0.708 rs3801965 chr7:106825628 G/T cg02696742 chr7:106810147 HBP1 -0.62 -6.8 -0.35 4.83e-11 Osteoarthritis; CRC cis rs13118159 0.899 rs3796613 chr4:1353321 A/T cg16405210 chr4:1374714 KIAA1530 -0.5 -7.09 -0.36 8.45e-12 Longevity; CRC cis rs9303401 0.659 rs11079357 chr17:56902778 A/G cg10487724 chr17:56770010 TEX14;RAD51C 0.76 9.58 0.47 2.51e-19 Cognitive test performance; CRC cis rs17152411 1.000 rs12571196 chr10:126597749 A/C cg07906193 chr10:126599966 NA 0.58 5.74 0.3 2.12e-8 Height; CRC trans rs7705042 0.865 rs2338821 chr5:141509433 A/G cg03701575 chr16:83960119 NA 0.34 5.97 0.31 6.14e-9 Asthma; CRC cis rs8060686 0.641 rs7204974 chr16:68033539 G/A cg08314208 chr16:67682810 RLTPR -0.5 -6.05 -0.32 3.99e-9 HDL cholesterol;Metabolic syndrome; CRC cis rs13191362 0.872 rs67712738 chr6:163245768 G/A cg21926612 chr6:163149169 PACRG;PARK2 0.7 8.94 0.44 2.78e-17 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs9322193 0.961 rs9285521 chr6:149906712 T/G cg00933542 chr6:150070202 PCMT1 0.33 6.67 0.34 1.11e-10 Lung cancer; CRC cis rs11122272 0.735 rs2790877 chr1:231535427 A/G cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.57 -8.6 -0.43 3.21e-16 Hemoglobin concentration; CRC cis rs3087591 1.000 rs2525578 chr17:29711411 A/G cg24425628 chr17:29625626 OMG;NF1 -0.78 -14.31 -0.62 1.94e-36 Hip circumference; CRC cis rs1552244 1.000 rs55882090 chr3:10139082 C/T cg08888203 chr3:10149979 C3orf24 0.67 9.77 0.47 6.02e-20 Alzheimer's disease; CRC cis rs2243480 1.000 rs34529418 chr7:65403209 A/G cg12463550 chr7:65579703 CRCP 0.63 6.04 0.32 4.17e-9 Diabetic kidney disease; CRC cis rs7591163 0.883 rs16824023 chr2:228720877 G/A cg01216370 chr2:228736459 WDR69 -0.42 -5.72 -0.3 2.45e-8 Blood pressure; CRC cis rs9287719 0.649 rs10929685 chr2:10732799 T/C cg00105475 chr2:10696890 NA 0.44 7.0 0.36 1.43e-11 Prostate cancer; CRC cis rs7727544 0.684 rs272849 chr5:131690241 A/G cg24060327 chr5:131705240 SLC22A5 -0.36 -5.73 -0.3 2.3e-8 Blood metabolite levels; CRC cis rs59918340 0.764 rs4961339 chr8:142231504 A/G cg03316587 chr8:142245164 NA -0.4 -5.94 -0.31 7.21e-9 Immature fraction of reticulocytes; CRC cis rs2479724 0.935 rs2025951 chr6:41827193 C/T cg17623882 chr6:41773611 USP49 0.56 9.62 0.47 1.78e-19 Menarche (age at onset); CRC cis rs10504229 0.724 rs16922734 chr8:58111192 C/T cg02725872 chr8:58115012 NA -0.66 -11.64 -0.54 1.83e-26 Developmental language disorder (linguistic errors); CRC cis rs853679 0.567 rs2232427 chr6:28359709 T/G cg21251018 chr6:28226885 NKAPL 0.42 5.91 0.31 8.51e-9 Depression; CRC cis rs2276314 1.000 rs2298715 chr18:33552425 T/C cg05985134 chr18:33552581 C18orf21 0.52 7.09 0.36 8.16e-12 Endometriosis;Drug-induced torsades de pointes; CRC cis rs881375 0.900 rs1008383 chr9:123683579 C/G cg09419670 chr9:123605666 PSMD5;LOC253039 0.59 8.77 0.44 9.66e-17 Rheumatoid arthritis; CRC cis rs9611565 0.592 rs28750375 chr22:41990644 A/C cg03806693 chr22:41940476 POLR3H -0.72 -9.39 -0.46 1.07e-18 Vitiligo; CRC trans rs11098499 0.863 rs3775843 chr4:120427844 T/C cg25214090 chr10:38739885 LOC399744 0.63 9.89 0.48 2.39e-20 Corneal astigmatism; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg08380957 chr17:58678329 PPM1D 0.44 6.37 0.33 6.29e-10 Intelligence (multi-trait analysis); CRC trans rs877282 0.733 rs11253342 chr10:765072 A/G cg22713356 chr15:30763199 NA 1.29 15.31 0.65 2.44e-40 Uric acid levels; CRC trans rs45509595 0.841 rs401754 chr6:27782538 T/A cg06606381 chr12:133084897 FBRSL1 -0.78 -6.64 -0.34 1.26e-10 Breast cancer; CRC cis rs950169 1.000 rs1818950 chr15:84722521 A/G cg11189052 chr15:85197271 WDR73 0.61 8.99 0.44 2.05e-17 Schizophrenia; CRC cis rs9527 0.590 rs12246739 chr10:104787019 A/C cg15744005 chr10:104629667 AS3MT 0.33 6.51 0.34 2.79e-10 Arsenic metabolism; CRC cis rs2576037 0.583 rs12386118 chr18:44540376 C/G cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.59 -8.83 -0.44 6.5e-17 Personality dimensions; CRC cis rs28386778 0.897 rs57108948 chr17:61802378 T/C cg22520471 chr17:61851767 DDX42;CCDC47 0.73 11.17 0.52 9.08e-25 Prudent dietary pattern; CRC cis rs2762353 0.595 rs1892256 chr6:25754271 C/T cg03264133 chr6:25882463 NA 0.72 10.08 0.49 5.16e-21 Blood metabolite levels; CRC cis rs7666738 0.830 rs10050008 chr4:99025313 T/G cg05340658 chr4:99064831 C4orf37 0.61 9.42 0.46 8.23e-19 Colonoscopy-negative controls vs population controls; CRC trans rs10411161 0.810 rs60981935 chr19:52385281 C/T cg22319618 chr22:45562946 NUP50 -0.69 -6.01 -0.31 4.9e-9 Breast cancer; CRC cis rs3820068 0.581 rs6692489 chr1:15928517 A/G cg24675056 chr1:15929824 NA 0.52 7.27 0.37 2.64e-12 Systolic blood pressure; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg25697769 chr22:39097335 JOSD1 0.41 6.9 0.36 2.63e-11 Liver disease severity in Alagille syndrome; CRC cis rs9858542 0.903 rs35999162 chr3:49597230 C/G cg03060546 chr3:49711283 APEH -0.48 -6.71 -0.35 8.69e-11 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs1005277 0.579 rs1780133 chr10:38499509 T/C cg00409905 chr10:38381863 ZNF37A -0.63 -10.36 -0.5 6.02e-22 Extrinsic epigenetic age acceleration; CRC cis rs8180040 0.764 rs4682852 chr3:47177772 C/T cg02527881 chr3:46936655 PTH1R -0.37 -6.97 -0.36 1.7e-11 Colorectal cancer; CRC cis rs62458065 0.640 rs79619897 chr7:32514819 C/T cg20159608 chr7:32802032 NA -0.59 -7.01 -0.36 1.39e-11 Metabolite levels (HVA/MHPG ratio); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg05643503 chr1:3713094 LRRC47 0.42 5.99 0.31 5.51e-9 Intelligence (multi-trait analysis); CRC cis rs2651899 0.902 rs1624023 chr1:3079337 C/T cg22674798 chr1:3096360 PRDM16 0.35 7.42 0.38 1.02e-12 Migraine; CRC cis rs9381040 0.674 rs4711657 chr6:41162715 G/A cg25110423 chr6:41068646 NFYA;LOC221442 -0.51 -7.68 -0.39 1.8e-13 Alzheimer's disease (late onset); CRC cis rs769267 0.930 rs10419912 chr19:19597055 A/G cg01262667 chr19:19385393 TM6SF2 -0.35 -5.72 -0.3 2.36e-8 Tonsillectomy; CRC cis rs1801251 1.000 rs6717841 chr2:233590255 C/T cg25237894 chr2:233734115 C2orf82 0.54 8.76 0.43 1.09e-16 Coronary artery disease; CRC cis rs4713118 0.868 rs742047 chr6:27739380 A/G cg02683197 chr6:28174875 NA 0.69 7.44 0.38 8.81e-13 Parkinson's disease; CRC cis rs8044868 0.530 rs2287999 chr16:72059149 A/G cg23815491 chr16:72088622 HP 0.47 6.95 0.36 1.94e-11 Body mass index (change over time) in cancer or chronic obstructive pulmonary disease;Body mass index (change over time) in cancer; CRC cis rs28386778 0.897 rs9912557 chr17:61784963 C/A cg22520471 chr17:61851767 DDX42;CCDC47 0.74 11.3 0.53 2.98e-25 Prudent dietary pattern; CRC cis rs12701220 0.503 rs12702024 chr7:1129820 G/C cg02733842 chr7:1102375 C7orf50 -0.81 -9.5 -0.46 4.34e-19 Bronchopulmonary dysplasia; CRC cis rs6951245 1.000 rs77702926 chr7:1088838 G/A cg24642844 chr7:1081250 C7orf50 -0.79 -9.35 -0.46 1.4e-18 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs68170813 0.562 rs17429825 chr7:107050731 C/T cg02696742 chr7:106810147 HBP1 -0.6 -6.45 -0.34 3.98e-10 Coronary artery disease; CRC cis rs1475911 1.000 rs1475911 chr21:43513480 A/C cg19766460 chr21:43528205 UMODL1;C21orf128 0.66 7.94 0.4 3.23e-14 IgG glycosylation; CRC cis rs4820294 0.646 rs9622675 chr22:38053665 G/T cg05691152 chr22:38092978 TRIOBP -0.31 -5.62 -0.3 4e-8 Fat distribution (HIV); CRC cis rs4523957 0.855 rs7217226 chr17:2136065 A/C cg16513277 chr17:2031491 SMG6 -0.53 -9.25 -0.45 2.98e-18 Autism spectrum disorder or schizophrenia;Schizophrenia; CRC cis rs9916302 0.752 rs9901219 chr17:37558369 T/G cg15445000 chr17:37608096 MED1 -0.42 -8.53 -0.43 5.46e-16 Glomerular filtration rate (creatinine); CRC cis rs28680850 0.541 rs4876041 chr8:1370441 T/C cg06035437 chr8:1398411 NA -0.42 -5.77 -0.3 1.83e-8 Triglycerides; CRC cis rs13082711 0.554 rs7635958 chr3:27385616 A/C cg02860705 chr3:27208620 NA 0.87 11.19 0.53 7.46e-25 Systolic blood pressure;Diastolic blood pressure;Blood pressure; CRC cis rs9326248 1.000 rs4938354 chr11:117051165 A/G cg10130564 chr11:117069849 TAGLN 0.38 7.13 0.37 6.48e-12 Blood protein levels; CRC cis rs1862618 0.802 rs832560 chr5:56124423 T/A cg12311346 chr5:56204834 C5orf35 -0.75 -10.15 -0.49 3.15e-21 Initial pursuit acceleration; CRC trans rs1814175 0.645 rs28634872 chr11:50042175 T/A cg15704280 chr7:45808275 SEPT13 -0.94 -17.39 -0.69 1.77e-48 Height; CRC cis rs11122272 0.764 rs4486439 chr1:231477470 C/T cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.53 -8.19 -0.41 5.76e-15 Hemoglobin concentration; CRC cis rs634534 0.561 rs613924 chr11:65769295 C/T cg17985854 chr11:65770987 BANF1;EIF1AD 0.53 8.97 0.44 2.27e-17 Sum eosinophil basophil counts;Eosinophil counts; CRC cis rs1448094 0.511 rs10863071 chr12:86145813 A/G cg19622623 chr12:86230825 RASSF9 0.4 6.35 0.33 7.12e-10 Major depressive disorder; CRC cis rs6460942 0.908 rs74801929 chr7:12232715 C/G cg06484146 chr7:12443880 VWDE -0.58 -6.05 -0.32 4.03e-9 Coronary artery disease; CRC cis rs2075671 0.903 rs11983334 chr7:100302434 C/T cg20848291 chr7:100343083 ZAN -0.66 -10.05 -0.48 6.81e-21 Other erythrocyte phenotypes; CRC cis rs7772486 0.790 rs9791313 chr6:146266172 T/C cg13319975 chr6:146136371 FBXO30 0.39 5.93 0.31 7.81e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs6693567 0.565 rs12739706 chr1:150261653 C/G cg15654264 chr1:150340011 RPRD2 -0.39 -5.8 -0.3 1.58e-8 Migraine; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg18715297 chr3:122283210 PARP9;DTX3L 0.38 6.03 0.32 4.3e-9 Intelligence (multi-trait analysis); CRC cis rs35123175 1 rs35123175 chr21:45006610 CA/C cg24875593 chr21:45153009 PDXK -0.72 -6.21 -0.32 1.6e-9 Diastolic blood pressure; CRC cis rs6754311 0.731 rs2322660 chr2:136557319 A/G cg25344623 chr2:136566232 LCT -0.32 -5.82 -0.31 1.37e-8 Mosquito bite size; CRC cis rs7677751 0.767 rs890205 chr4:55063373 C/A cg00691999 chr4:55094011 PDGFRA 0.4 5.7 0.3 2.73e-8 Corneal astigmatism; CRC cis rs4727027 0.933 rs1044358 chr7:148879951 C/A cg12479418 chr7:148823350 ZNF425;ZNF398 0.44 6.03 0.32 4.43e-9 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC cis rs12594515 1.000 rs6493176 chr15:45990026 A/G cg22117107 chr15:45993392 NA -0.44 -9.09 -0.45 9.56e-18 Waist circumference;Weight; CRC cis rs4713118 0.513 rs149958 chr6:28013617 A/C cg06470822 chr6:28175283 NA 0.8 11.94 0.55 1.56e-27 Parkinson's disease; CRC cis rs12701220 0.522 rs1881116 chr7:1053958 C/T cg02733842 chr7:1102375 C7orf50 -0.51 -6.93 -0.36 2.29e-11 Bronchopulmonary dysplasia; CRC cis rs3771570 0.901 rs62190415 chr2:242426692 A/G cg21155796 chr2:242212141 HDLBP 0.59 6.65 0.34 1.21e-10 Prostate cancer; CRC cis rs6088580 0.668 rs1205340 chr20:32923871 G/A cg08999081 chr20:33150536 PIGU -0.64 -11.72 -0.54 9.6800000000000007e-27 Glomerular filtration rate (creatinine); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg10663503 chr17:8126298 C17orf44 0.45 6.33 0.33 7.81e-10 Response to antipsychotic treatment; CRC cis rs11122272 0.701 rs2883799 chr1:231531166 C/G cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.58 -8.75 -0.43 1.1e-16 Hemoglobin concentration; CRC cis rs7086627 0.515 rs1870147 chr10:82212541 A/T cg00277334 chr10:82204260 NA -0.82 -15.74 -0.66 5.1e-42 Post bronchodilator FEV1; CRC cis rs2180341 0.513 rs12196828 chr6:127696864 C/T cg24812749 chr6:127587940 RNF146 0.64 9.59 0.47 2.2e-19 Breast cancer; CRC cis rs17345786 0.906 rs59359251 chr3:101146362 A/C cg12386194 chr3:101231763 SENP7 0.56 7.29 0.37 2.35e-12 Colonoscopy-negative controls vs population controls; CRC cis rs10189230 0.967 rs13012429 chr2:222350788 C/T cg14652038 chr2:222343519 EPHA4 0.52 10.01 0.48 8.96e-21 Urate levels in lean individuals; CRC trans rs12408261 0.685 rs4085125 chr1:189277546 A/T cg09627744 chr16:77228780 MON1B 0.39 5.97 0.31 6.11e-9 Number of pregnancies; CRC cis rs2354432 0.546 rs11240030 chr1:146882616 G/A cg25205988 chr1:146714368 CHD1L 0.98 10.41 0.5 4.11e-22 Mitochondrial DNA levels; CRC cis rs35306767 0.668 rs12356612 chr10:1055055 C/T cg26597838 chr10:835615 NA 0.86 10.22 0.49 1.77e-21 Eosinophil percentage of granulocytes; CRC cis rs7666738 0.830 rs6854994 chr4:98977624 C/G cg17366294 chr4:99064904 C4orf37 0.44 7.44 0.38 8.98e-13 Colonoscopy-negative controls vs population controls; CRC cis rs3824347 0.839 rs4537368 chr9:77587067 G/A cg01251476 chr9:77566080 C9orf40 0.37 5.7 0.3 2.66e-8 Urinary magnesium-to-creatinine ratio; CRC cis rs9303280 0.742 rs11557466 chr17:38024626 C/T cg17344932 chr17:38183730 MED24;SNORD124 0.37 5.92 0.31 8.26e-9 Self-reported allergy; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg19737787 chr13:28492265 NA -0.39 -6.24 -0.33 1.32e-9 Myopia (pathological); CRC cis rs7107174 0.901 rs10899494 chr11:78122208 G/T cg02023728 chr11:77925099 USP35 0.42 6.3 0.33 9.33e-10 Testicular germ cell tumor; CRC cis rs775227 0.528 rs775231 chr3:113027214 A/C cg10517650 chr3:113235015 CCDC52 0.34 5.61 0.3 4.22e-8 Dental caries; CRC cis rs644799 0.710 rs10831427 chr11:95508383 G/T cg25478527 chr11:95522999 CEP57;FAM76B 0.5 7.57 0.38 3.89e-13 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs736408 0.522 rs998909 chr3:52805093 A/G cg10802521 chr3:52805072 NEK4 -0.58 -8.99 -0.44 1.98e-17 Bipolar disorder; CRC cis rs6840360 1.000 rs6535818 chr4:152650882 T/G cg09659197 chr4:152720779 NA 0.53 11.67 0.54 1.49e-26 Intelligence (multi-trait analysis); CRC cis rs11212617 1.000 rs599558 chr11:108177538 C/T cg01991180 chr11:108092276 ATM;NPAT 0.43 6.34 0.33 7.79e-10 Response to metformin in type 2 diabetes (glycemic); CRC cis rs2576037 0.583 rs892586 chr18:44560429 C/A cg20875182 chr18:44561130 TCEB3B;KATNAL2 -0.6 -9.81 -0.48 4.16e-20 Personality dimensions; CRC trans rs61931739 0.500 rs9669027 chr12:34583528 C/T cg26384229 chr12:38710491 ALG10B -0.61 -8.95 -0.44 2.57e-17 Morning vs. evening chronotype; CRC cis rs174601 0.864 rs174545 chr11:61569306 C/G cg06781209 chr11:61594997 FADS2 -0.38 -5.74 -0.3 2.11e-8 Blood metabolite levels;Red blood cell fatty acid levels;Liver enzyme levels (alkaline phosphatase);Gondoic acid (20:1n-9) levels;Trans fatty acid levels; CRC cis rs875971 0.658 rs432667 chr7:65514633 A/G cg00343986 chr7:65444356 GUSB 0.47 6.96 0.36 1.88e-11 Aortic root size; CRC cis rs7647973 0.580 rs2334958 chr3:49252364 C/T cg06212747 chr3:49208901 KLHDC8B 0.38 5.71 0.3 2.58e-8 Menarche (age at onset); CRC cis rs4148883 0.713 rs3828541 chr4:100042262 A/G cg13256891 chr4:100009986 ADH5 0.45 6.64 0.34 1.29e-10 Alcohol dependence; CRC cis rs9914988 0.887 rs11656272 chr17:27091153 A/G cg16670446 chr17:27188758 MIR451;MIR144 0.55 8.55 0.43 4.83e-16 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs742115 0.563 rs12663475 chr6:11297296 T/C cg25250968 chr6:11318770 NEDD9 -0.39 -7.61 -0.39 2.83e-13 Coronary artery disease; CRC cis rs4332037 0.722 rs4719332 chr7:1914681 G/A cg23422044 chr7:1970798 MAD1L1 -0.6 -7.92 -0.4 3.64e-14 Bipolar disorder; CRC cis rs875971 0.862 rs6460307 chr7:66060871 A/G cg11764359 chr7:65958608 NA 0.56 8.4 0.42 1.37e-15 Aortic root size; CRC cis rs8040855 0.547 rs17611171 chr15:85572699 T/A cg10818794 chr15:86012489 AKAP13 -0.45 -5.94 -0.31 7.37e-9 Bulimia nervosa; CRC trans rs4689592 0.587 rs3822269 chr4:7069901 T/C cg07817883 chr1:32538562 TMEM39B -0.61 -7.56 -0.38 4.01e-13 Monocyte percentage of white cells; CRC cis rs10208940 0.920 rs13422657 chr2:68706989 T/C cg12452813 chr2:68675892 NA 0.52 6.43 0.33 4.44e-10 Urate levels in lean individuals; CRC cis rs7312933 0.558 rs4768411 chr12:42855390 A/G cg11827402 chr12:42719852 PPHLN1;ZCRB1 -0.62 -8.78 -0.44 9.42e-17 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CRC cis rs6933660 0.666 rs9371516 chr6:151739642 G/A cg10883421 chr6:151773342 RMND1;C6orf211 0.72 12.75 0.58 1.54e-30 Menarche (age at onset); CRC cis rs780096 0.526 rs12476704 chr2:27613031 C/A cg17158414 chr2:27665306 KRTCAP3 -0.29 -6.06 -0.32 3.74e-9 Total body bone mineral density; CRC trans rs4295623 0.553 rs34962960 chr8:11594597 G/A cg06636001 chr8:8085503 FLJ10661 -0.55 -8.3 -0.42 2.77e-15 Morning vs. evening chronotype; CRC cis rs12023718 0.588 rs74471321 chr1:178605292 A/C cg00404053 chr1:178313656 RASAL2 0.58 7.32 0.37 1.9e-12 Obesity-related traits; CRC cis rs7552404 0.727 rs7547056 chr1:76279267 C/T cg10523679 chr1:76189770 ACADM 0.7 9.16 0.45 5.49e-18 Blood metabolite levels;Acylcarnitine levels; CRC cis rs6540556 0.954 rs6540555 chr1:209936571 A/G cg23920097 chr1:209922102 NA -0.55 -7.03 -0.36 1.16e-11 Red blood cell count; CRC cis rs7953508 0.750 rs7310389 chr12:93976636 A/G cg18151635 chr12:93972918 NA -0.57 -8.24 -0.41 4.06e-15 Pubertal anthropometrics; CRC cis rs7666738 0.791 rs62318641 chr4:98816964 T/C cg05340658 chr4:99064831 C4orf37 0.54 7.77 0.39 9.92e-14 Colonoscopy-negative controls vs population controls; CRC cis rs7666738 0.830 rs7698771 chr4:98986479 T/G cg05340658 chr4:99064831 C4orf37 0.6 9.41 0.46 8.57e-19 Colonoscopy-negative controls vs population controls; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg20569680 chr6:16129335 MYLIP 0.48 6.74 0.35 7.08e-11 Response to antipsychotic treatment; CRC cis rs9372498 0.706 rs9489396 chr6:118761703 A/C cg24463073 chr6:118973353 C6orf204 0.52 6.83 0.35 4.24e-11 Diastolic blood pressure; CRC cis rs10046574 0.561 rs17403528 chr7:135195531 C/T cg27474649 chr7:135195673 CNOT4 0.68 6.24 0.33 1.34e-9 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs7258465 1.000 rs10409505 chr19:18590251 C/G cg10790698 chr19:18539756 SSBP4 -0.45 -8.61 -0.43 3.07e-16 Breast cancer; CRC cis rs2985684 1.000 rs56098064 chr14:50105849 T/C cg04989706 chr14:50066350 PPIL5 -0.51 -7.24 -0.37 3.29e-12 Carotid intima media thickness; CRC cis rs3858526 0.920 rs11039698 chr11:5950907 C/T cg13902645 chr11:5959945 NA -0.64 -9.0 -0.44 1.81e-17 DNA methylation (variation); CRC cis rs733592 0.524 rs10875727 chr12:48426143 T/C cg21466736 chr12:48725269 NA 0.49 7.72 0.39 1.41e-13 Plateletcrit; CRC cis rs6545883 0.507 rs59981505 chr2:61580529 G/T cg10580144 chr2:61372316 C2orf74 -0.35 -7.75 -0.39 1.13e-13 Tuberculosis; CRC cis rs10751667 0.666 rs6597966 chr11:950750 T/C cg06064525 chr11:970664 AP2A2 -0.31 -6.2 -0.32 1.71e-9 Alzheimer's disease (late onset); CRC cis rs7680126 0.633 rs2868937 chr4:10303081 C/T cg11266682 chr4:10021025 SLC2A9 -0.47 -6.99 -0.36 1.5e-11 Urate levels in lean individuals;Urate levels in overweight individuals;Urate levels in obese individuals; CRC cis rs3741151 0.686 rs12285885 chr11:73294478 A/G cg17517138 chr11:73019481 ARHGEF17 0.55 5.7 0.3 2.71e-8 GIP levels in response to oral glucose tolerance test (120 minutes); CRC cis rs877282 0.945 rs35342920 chr10:790484 T/C cg06581033 chr10:766294 NA -0.51 -5.68 -0.3 2.97e-8 Uric acid levels; CRC cis rs10503871 0.905 rs6993952 chr8:30440564 T/C cg26383811 chr8:30366931 RBPMS 0.46 7.41 0.38 1.11e-12 Metabolite levels (X-11787); CRC cis rs67311347 1.000 rs73078163 chr3:40479958 C/T cg24209194 chr3:40518798 ZNF619 0.42 5.9 0.31 9.18e-9 Renal cell carcinoma; CRC trans rs7395662 0.591 rs11039858 chr11:48611651 C/T cg21153622 chr11:89784906 NA -0.54 -8.82 -0.44 6.58e-17 HDL cholesterol; CRC cis rs12541335 0.639 rs4871994 chr8:22206038 G/A cg18135555 chr8:22132992 PIWIL2 0.41 7.89 0.4 4.54e-14 Hypertriglyceridemia; CRC cis rs3785574 0.962 rs62077509 chr17:61848973 A/G cg06873352 chr17:61820015 STRADA 0.5 8.04 0.41 1.68e-14 Height; CRC cis rs916888 0.773 rs199535 chr17:44822662 A/G cg01570182 chr17:44337453 NA 1.22 14.44 0.62 6.15e-37 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs3087591 0.960 rs2905802 chr17:29520084 T/C cg24425628 chr17:29625626 OMG;NF1 0.83 15.7 0.65 7.76e-42 Hip circumference; CRC cis rs11214589 0.747 rs10891536 chr11:113209428 C/G cg14159747 chr11:113255604 NA 0.5 9.2 0.45 4.34e-18 Neuroticism; CRC cis rs11190604 0.945 rs2495735 chr10:102338609 G/A cg16342193 chr10:102329863 NA -0.33 -5.69 -0.3 2.8e-8 Palmitoleic acid (16:1n-7) levels; CRC trans rs8073060 0.586 rs4796104 chr17:34046832 T/C cg19694781 chr19:47549865 TMEM160 1.08 14.73 0.63 4.38e-38 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; CRC cis rs1552244 0.935 rs35148833 chr3:10116937 C/A cg02579736 chr3:10068473 FANCD2;CIDECP 1.02 13.77 0.6 2.25e-34 Alzheimer's disease; CRC cis rs13082711 0.911 rs66694067 chr3:27477337 C/T cg02860705 chr3:27208620 NA 0.63 8.89 0.44 4.23e-17 Systolic blood pressure;Diastolic blood pressure;Blood pressure; CRC cis rs58688157 0.705 rs12419720 chr11:598205 C/G cg02461776 chr11:598696 PHRF1 0.47 5.96 0.31 6.64e-9 Systemic lupus erythematosus; CRC cis rs7216064 0.589 rs7213585 chr17:66062316 A/T cg12091567 chr17:66097778 LOC651250 -0.87 -12.74 -0.57 1.65e-30 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CRC cis rs7552404 0.924 rs1251075 chr1:76190569 C/G cg22875332 chr1:76189707 ACADM 0.7 10.85 0.51 1.16e-23 Blood metabolite levels;Acylcarnitine levels; CRC cis rs6502050 0.723 rs11650635 chr17:80083816 T/C cg22110888 chr17:80059540 CCDC57 -0.41 -6.39 -0.33 5.58e-10 Life satisfaction; CRC cis rs6860806 0.507 rs274572 chr5:131710917 T/G cg20512303 chr5:131592959 PDLIM4 -0.39 -6.68 -0.35 1.02e-10 Breast cancer; CRC trans rs61931739 0.500 rs11053194 chr12:34440841 A/G cg26384229 chr12:38710491 ALG10B 0.62 9.11 0.45 8.28e-18 Morning vs. evening chronotype; CRC cis rs11098499 0.644 rs28787668 chr4:120554687 G/A cg24375607 chr4:120327624 NA 0.48 7.49 0.38 6.31e-13 Corneal astigmatism; CRC cis rs6459788 0.720 rs11974772 chr7:157250645 G/A cg01766193 chr7:157202248 DNAJB6 -0.35 -5.72 -0.3 2.39e-8 Epstein-Barr virus copy number in lymphoblastoid cell lines; CRC cis rs208520 0.690 rs12202401 chr6:66760544 A/G cg07460842 chr6:66804631 NA 1.05 14.68 0.63 7.05e-38 Exhaled nitric oxide output; CRC cis rs7811142 1.000 rs73161762 chr7:100014846 C/T cg00814883 chr7:100076585 TSC22D4 -0.78 -9.64 -0.47 1.52e-19 Platelet count; CRC cis rs9868809 0.505 rs11706983 chr3:48738678 A/G cg07636037 chr3:49044803 WDR6 -0.68 -6.53 -0.34 2.57e-10 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; CRC cis rs773506 0.655 rs4744037 chr9:93932488 C/G cg14446406 chr9:93919335 NA -0.45 -7.71 -0.39 1.48e-13 Type 2 diabetes nephropathy; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg23377693 chr6:43597122 MAD2L1BP;GTPBP2 0.49 6.98 0.36 1.67e-11 Response to antipsychotic treatment; CRC trans rs1005277 0.579 rs2474568 chr10:38383147 A/T cg11292332 chr7:45801988 SEPT13 -0.35 -6.27 -0.33 1.14e-9 Extrinsic epigenetic age acceleration; CRC cis rs2882667 1.000 rs10064201 chr5:138309405 C/T cg09476006 chr5:138032270 NA 0.45 7.35 0.38 1.53e-12 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs6089584 0.566 rs11699442 chr20:60623268 A/G cg06108461 chr20:60628389 TAF4 -0.74 -12.07 -0.55 5.07e-28 Body mass index; CRC cis rs4332037 0.624 rs11766944 chr7:1888051 G/A cg25834613 chr7:1915315 MAD1L1 -0.41 -6.29 -0.33 1e-9 Bipolar disorder; CRC cis rs2949837 0.581 rs2960436 chr7:45977282 G/A cg21268650 chr7:45961089 IGFBP3 0.38 6.41 0.33 5.05e-10 Sitting height ratio; CRC cis rs2996428 0.561 rs16824192 chr1:3748605 G/A cg13057898 chr1:3703894 LRRC47 0.56 7.6 0.39 3.04e-13 Red cell distribution width; CRC cis rs6558530 0.932 rs7846610 chr8:1706675 C/T cg19131313 chr8:1704013 NA -0.44 -5.9 -0.31 8.84e-9 Systolic blood pressure; CRC cis rs7552404 0.960 rs12134854 chr1:76137606 A/G cg22875332 chr1:76189707 ACADM 0.62 8.55 0.43 4.88e-16 Blood metabolite levels;Acylcarnitine levels; CRC cis rs7727544 0.636 rs2631365 chr5:131705949 T/C cg04518342 chr5:131593106 PDLIM4 -0.32 -5.7 -0.3 2.67e-8 Blood metabolite levels; CRC cis rs9322193 0.962 rs1413655 chr6:150142951 A/G cg07701084 chr6:150067640 NUP43 0.48 6.65 0.34 1.21e-10 Lung cancer; CRC trans rs2976388 0.565 rs2572905 chr8:143797104 C/T cg24628676 chr5:59189846 PDE4D -0.3 -6.05 -0.32 4.03e-9 Urinary tract infection frequency; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg08833546 chr7:66461892 TYW1;SBDS 0.48 6.6 0.34 1.66e-10 Anxiety disorder; CRC cis rs7429990 0.965 rs319696 chr3:47943861 T/C cg11946769 chr3:48343235 NME6 0.46 5.9 0.31 8.99e-9 Educational attainment (years of education); CRC cis rs4290604 0.596 rs7566199 chr2:238053391 A/G cg23555395 chr2:238036564 NA -0.67 -6.85 -0.35 3.58e-11 Asthma; CRC cis rs11098499 0.569 rs55845118 chr4:120290913 T/C cg09307838 chr4:120376055 NA 0.68 10.53 0.5 1.51e-22 Corneal astigmatism; CRC cis rs66887589 0.967 rs7678973 chr4:120511817 T/C cg09307838 chr4:120376055 NA -0.51 -7.77 -0.39 1.02e-13 Diastolic blood pressure; CRC cis rs11971779 0.680 rs17613690 chr7:139088401 C/T cg07862535 chr7:139043722 LUC7L2 -0.59 -7.62 -0.39 2.72e-13 Diisocyanate-induced asthma; CRC trans rs10506458 0.915 rs2013050 chr12:63394310 C/T cg22491629 chr6:157744540 C6orf35 -0.78 -9.13 -0.45 6.9e-18 Hemostatic factors and hematological phenotypes; CRC cis rs501120 0.584 rs677465 chr10:44732917 G/A cg09554077 chr10:44749378 NA 0.66 7.26 0.37 2.83e-12 Coronary artery disease;Coronary heart disease; CRC cis rs7312933 0.558 rs3747560 chr12:42719890 A/G cg19980929 chr12:42632907 YAF2 -0.39 -5.9 -0.31 9.12e-9 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CRC cis rs10789491 1.000 rs11211342 chr1:47163098 T/C cg15501359 chr1:47185051 KIAA0494 0.7 8.3 0.42 2.82e-15 Response to hepatitis C treatment; CRC cis rs1448094 0.737 rs10863135 chr12:86382657 C/T cg19622623 chr12:86230825 RASSF9 -0.36 -5.79 -0.3 1.62e-8 Major depressive disorder; CRC cis rs4563143 0.663 rs10406794 chr19:29228056 C/T cg14983838 chr19:29218262 NA 0.56 8.65 0.43 2.25e-16 Methadone dose in opioid dependence; CRC cis rs4713118 0.539 rs200951 chr6:27835930 A/G cg20933634 chr6:27740509 NA 0.5 7.01 0.36 1.39e-11 Parkinson's disease; CRC cis rs2289583 0.503 rs113742359 chr15:75261643 A/G cg14664628 chr15:75095509 CSK 0.45 5.97 0.31 6.2e-9 Systemic lupus erythematosus; CRC cis rs826838 1.000 rs11183214 chr12:38692938 C/T cg26384229 chr12:38710491 ALG10B 0.76 10.77 0.51 2.24e-23 Heart rate; CRC cis rs1878931 0.582 rs27227 chr16:3429778 G/A cg26668626 chr16:3451006 ZNF174;ZNF434 -0.57 -7.01 -0.36 1.39e-11 Body mass index (adult); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg22841336 chr12:57040011 ATP5B;SNORD59A 0.43 6.2 0.32 1.73e-9 Response to antipsychotic treatment; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg00807959 chr1:48176281 NA 0.37 6.14 0.32 2.37e-9 Liver disease severity in Alagille syndrome; CRC cis rs929354 0.742 rs10274687 chr7:156933181 T/G cg17757837 chr7:157058334 UBE3C 0.74 12.39 0.56 3.31e-29 Body mass index; CRC cis rs7811142 0.887 rs4074838 chr7:100032665 G/A cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.99 13.63 0.6 7.31e-34 Platelet count; CRC cis rs427941 0.703 rs201448 chr7:101738860 T/C cg06246474 chr7:101738831 CUX1 0.46 7.25 0.37 3.02e-12 Plasma omega-3 polyunsaturated fatty acid level (eicosapentaenoic acid); CRC cis rs6662572 0.737 rs72677518 chr1:46511118 T/C cg08644498 chr1:46502608 NA 0.47 7.52 0.38 5.41e-13 Blood protein levels; CRC cis rs4662945 0.688 rs10496679 chr2:130201113 G/A cg05962382 chr2:130345044 NA -0.33 -5.75 -0.3 2.04e-8 Response to cytidine analogues (gemcitabine); CRC cis rs1005277 0.602 rs1831315 chr10:38473353 T/C cg25427524 chr10:38739819 LOC399744 -0.77 -13.42 -0.59 4.9e-33 Extrinsic epigenetic age acceleration; CRC trans rs2727020 0.553 rs61904166 chr11:49581461 T/C cg11707556 chr5:10655725 ANKRD33B -0.42 -7.79 -0.39 8.72e-14 Coronary artery disease; CRC cis rs3026101 0.671 rs886361 chr17:5292762 C/T cg25236894 chr17:5323110 RPAIN;NUP88 0.42 6.84 0.35 3.98e-11 Body mass index; CRC cis rs4332037 0.539 rs56180486 chr7:2050747 C/T cg24505167 chr7:1915268 MAD1L1 -0.44 -6.02 -0.31 4.77e-9 Bipolar disorder; CRC cis rs6754311 0.773 rs309125 chr2:136643555 C/T cg15123519 chr2:136567270 LCT -0.33 -6.18 -0.32 1.86e-9 Mosquito bite size; CRC cis rs775227 0.574 rs55693215 chr3:113064094 T/C cg18753928 chr3:113234510 CCDC52 -0.57 -6.92 -0.36 2.32e-11 Dental caries; CRC cis rs12701220 0.655 rs10241018 chr7:1144774 G/C cg26769984 chr7:1090371 C7orf50 0.54 7.4 0.38 1.17e-12 Bronchopulmonary dysplasia; CRC cis rs2228479 0.850 rs11076624 chr16:89855749 T/C cg19635926 chr16:89946313 TCF25 0.65 6.09 0.32 3.17e-9 Skin colour saturation; CRC cis rs9487051 0.872 rs9487033 chr6:109605388 C/G cg12927641 chr6:109611667 NA 0.39 6.96 0.36 1.88e-11 Reticulocyte fraction of red cells; CRC cis rs7264396 0.563 rs2425090 chr20:34304783 C/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.49 -6.74 -0.35 7.19e-11 Total cholesterol levels; CRC cis rs2777491 0.957 rs7163788 chr15:41704789 A/G cg18705301 chr15:41695430 NDUFAF1 -0.72 -12.39 -0.56 3.34e-29 Ulcerative colitis; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg25208863 chr8:110656982 GOLSYN 0.4 6.23 0.32 1.39e-9 Response to antipsychotic treatment; CRC cis rs763121 0.962 rs6001193 chr22:39074737 A/G cg06022373 chr22:39101656 GTPBP1 0.75 12.38 0.56 3.73e-29 Menopause (age at onset); CRC cis rs7666738 0.830 rs1426665 chr4:99027764 C/T cg05340658 chr4:99064831 C4orf37 0.59 8.97 0.44 2.22e-17 Colonoscopy-negative controls vs population controls; CRC trans rs7015657 0.637 rs11996651 chr8:20994930 C/G cg21446102 chr12:32831969 DNM1L 0.4 6.03 0.32 4.41e-9 Migraine with aura; CRC trans rs7395662 0.625 rs11040006 chr11:48774302 G/A cg21153622 chr11:89784906 NA 0.43 6.99 0.36 1.56e-11 HDL cholesterol; CRC cis rs13191362 0.935 rs67084568 chr6:162988548 C/A cg06582575 chr6:163149167 PACRG;PARK2 0.8 10.98 0.52 4.33e-24 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs4481887 0.888 rs4525076 chr1:248456876 T/G cg13385794 chr1:248469461 NA 0.37 6.51 0.34 2.82e-10 Common traits (Other); CRC cis rs4665809 0.590 rs2303892 chr2:26461733 C/G cg26119090 chr2:26468346 HADHA;HADHB 1.06 15.53 0.65 3.62e-41 Gut microbiome composition (summer); CRC trans rs1455244 0.700 rs7229302 chr18:11508904 G/T cg08347042 chr19:45579378 ZNF296 0.43 6.74 0.35 7.04e-11 Schizophrenia; CRC cis rs7584330 0.910 rs880932 chr2:238396963 A/G cg16989719 chr2:238392110 NA -0.4 -7.28 -0.37 2.52e-12 Prostate cancer; CRC cis rs875971 0.522 rs1917563 chr7:65415647 C/T cg02869306 chr7:64672164 INTS4L1 0.37 6.26 0.33 1.18e-9 Aortic root size; CRC cis rs7215564 0.730 rs34806161 chr17:78573839 T/C cg09596252 chr17:78655493 RPTOR 0.67 6.33 0.33 8.18e-10 Myopia (pathological); CRC cis rs4664293 0.625 rs6745448 chr2:160555598 A/G cg08347373 chr2:160653686 CD302 -0.39 -6.64 -0.34 1.3100000000000001e-10 Monocyte percentage of white cells; CRC cis rs9649213 0.593 rs6465666 chr7:97937258 C/T cg21770322 chr7:97807741 LMTK2 -0.52 -8.65 -0.43 2.32e-16 Prostate cancer (SNP x SNP interaction); CRC cis rs1552244 0.935 rs66493421 chr3:10092569 G/A cg16606324 chr3:10149918 C3orf24 0.66 7.62 0.39 2.65e-13 Alzheimer's disease; CRC cis rs2762353 0.935 rs3757130 chr6:25770866 C/T cg03264133 chr6:25882463 NA 0.48 7.05 0.36 1.06e-11 Blood metabolite levels; CRC cis rs7312933 0.618 rs7954523 chr12:42681508 A/G cg11827402 chr12:42719852 PPHLN1;ZCRB1 0.63 8.84 0.44 5.7e-17 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CRC cis rs2115630 1.000 rs55646601 chr15:85323568 G/T cg09876464 chr15:85330779 ZNF592 0.46 7.82 0.4 7.39e-14 P wave terminal force; CRC cis rs763121 0.853 rs10135 chr22:39082174 C/T cg06544989 chr22:39130855 UNC84B -0.49 -8.0 -0.4 2.19e-14 Menopause (age at onset); CRC cis rs17443541 0.507 rs12622777 chr2:200465331 G/A cg03741458 chr2:200468445 NA -0.36 -5.77 -0.3 1.82e-8 Intelligence (multi-trait analysis); CRC cis rs1971762 0.545 rs4759280 chr12:54064958 C/A cg06632207 chr12:54070931 ATP5G2 0.5 8.61 0.43 3.11e-16 Height; CRC cis rs561341 0.941 rs736678 chr17:30347423 G/T cg19193384 chr17:30244184 NA -0.65 -7.63 -0.39 2.48e-13 Hip circumference adjusted for BMI; CRC cis rs9419702 0.568 rs11156445 chr10:133542301 T/C cg04492858 chr10:133558786 NA 0.36 5.82 0.31 1.39e-8 Survival in rectal cancer; CRC cis rs593982 1.000 rs665191 chr11:65493658 G/A cg08755490 chr11:65554678 OVOL1 1.07 14.4 0.62 8.62e-37 Atopic dermatitis; CRC cis rs72634258 0.945 rs34157438 chr1:8023586 C/T cg00042356 chr1:8021962 PARK7 0.69 7.36 0.38 1.49e-12 Inflammatory bowel disease; CRC cis rs3858526 0.584 rs10769274 chr11:5866925 T/C cg02574844 chr11:5959923 NA -0.49 -7.14 -0.37 5.87e-12 DNA methylation (variation); CRC trans rs1728785 1.000 rs1645928 chr16:68590610 G/T cg04657470 chr2:198365150 HSPE1;HSPD1 0.76 9.01 0.44 1.73e-17 Ulcerative colitis; CRC cis rs1218582 0.772 rs10796934 chr1:154849479 C/G cg09359103 chr1:154839909 KCNN3 -0.75 -13.76 -0.6 2.37e-34 Prostate cancer; CRC cis rs9393777 0.513 rs9368447 chr6:26646674 A/C cg12292205 chr6:26970375 C6orf41 -0.61 -6.99 -0.36 1.52e-11 Intelligence (multi-trait analysis); CRC cis rs644799 0.601 rs568878 chr11:95578694 G/T cg25478527 chr11:95522999 CEP57;FAM76B 0.42 6.36 0.33 6.67e-10 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC trans rs6600671 1.000 rs1856572 chr1:121169579 A/C cg00646200 chr1:148855367 NA 0.35 6.35 0.33 7.24e-10 Hip geometry; CRC cis rs2243480 0.831 rs57294491 chr7:65684901 T/A cg25985355 chr7:65971099 NA 0.51 5.76 0.3 1.98e-8 Diabetic kidney disease; CRC cis rs7208859 0.623 rs11657777 chr17:29091785 T/C cg01831904 chr17:28903510 LRRC37B2 -0.63 -6.45 -0.33 4.07e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs796364 0.806 rs115717210 chr2:201006247 T/C cg25936922 chr2:200820526 C2orf60;C2orf47 -0.65 -6.15 -0.32 2.23e-9 Schizophrenia; CRC cis rs1707322 0.928 rs6681068 chr1:46398382 G/A cg06784218 chr1:46089804 CCDC17 0.51 9.02 0.45 1.57e-17 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs950169 1.000 rs11638297 chr15:84782417 A/C cg03959625 chr15:84868606 LOC388152 0.41 6.09 0.32 3.15e-9 Schizophrenia; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg20902146 chr12:101802045 ARL1 0.37 6.03 0.32 4.44e-9 Liver disease severity in Alagille syndrome; CRC cis rs10875746 0.859 rs11558768 chr12:48577789 C/T cg26205652 chr12:48591994 NA 0.48 5.92 0.31 8.04e-9 Longevity (90 years and older); CRC cis rs6502050 0.835 rs62078305 chr17:80085326 G/A cg19223190 chr17:80058835 NA -0.39 -6.24 -0.33 1.31e-9 Life satisfaction; CRC cis rs6496044 0.963 rs7165300 chr15:86070069 G/C cg17133734 chr15:86042851 AKAP13 0.41 6.23 0.32 1.45e-9 Interstitial lung disease; CRC cis rs4919694 1.000 rs12257941 chr10:104833161 C/T cg04362960 chr10:104952993 NT5C2 1.13 10.2 0.49 2.14e-21 Arsenic metabolism; CRC trans rs7615952 0.546 rs2922194 chr3:125332263 G/A cg02560186 chr11:3602584 NA -0.57 -6.91 -0.36 2.45e-11 Blood pressure (smoking interaction); CRC cis rs4713118 0.869 rs9461405 chr6:27719375 G/T cg15786705 chr6:28176104 NA 0.54 7.61 0.39 2.97e-13 Parkinson's disease; CRC trans rs11088226 0.681 rs1015048 chr21:33949306 T/C cg09050820 chr6:167586206 TCP10L2 0.9 9.7 0.47 9.87e-20 Gastritis; CRC cis rs7809950 0.817 rs2712224 chr7:107181235 C/A cg23024343 chr7:107201750 COG5 -0.75 -10.2 -0.49 2.08e-21 Coronary artery disease; CRC trans rs1728785 1.000 rs8058314 chr16:68584151 G/A cg04657470 chr2:198365150 HSPE1;HSPD1 0.58 7.07 0.36 9.08e-12 Ulcerative colitis; CRC cis rs79349575 0.783 rs58591767 chr17:47026076 G/A cg22482690 chr17:47019901 SNF8 0.5 8.26 0.41 3.58e-15 Type 2 diabetes; CRC cis rs6060717 0.654 rs6060686 chr20:34512606 C/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.59 -9.11 -0.45 8.5e-18 Hip circumference adjusted for BMI; CRC trans rs1864729 1.000 rs1864729 chr8:98282189 G/A cg08679828 chr8:102218111 ZNF706 -0.67 -8.01 -0.4 2.03e-14 Estradiol plasma levels (breast cancer); CRC cis rs854765 0.505 rs4924832 chr17:17897739 A/G cg09796270 chr17:17721594 SREBF1 0.46 7.79 0.39 8.77e-14 Total body bone mineral density; CRC cis rs4423214 0.879 rs1790324 chr11:71150520 A/C cg05163923 chr11:71159392 DHCR7 -0.63 -7.99 -0.4 2.33e-14 Vitamin D levels; CRC cis rs1552244 0.882 rs13066757 chr3:10045030 C/A cg13047869 chr3:10149882 C3orf24 0.53 7.15 0.37 5.57e-12 Alzheimer's disease; CRC cis rs780096 0.526 rs7594812 chr2:27611469 A/G cg27432699 chr2:27873401 GPN1 -0.5 -7.56 -0.38 4.14e-13 Total body bone mineral density; CRC cis rs11105298 0.891 rs6538189 chr12:89885923 C/A cg00757033 chr12:89920650 WDR51B 0.38 6.41 0.33 5.02e-10 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg00236302 chr12:69004867 RAP1B 0.43 6.6 0.34 1.62e-10 Liver disease severity in Alagille syndrome; CRC trans rs7944735 0.517 rs1827503 chr11:48225115 G/T cg03929089 chr4:120376271 NA 0.69 6.76 0.35 6.46e-11 Intraocular pressure; CRC trans rs4942242 0.663 rs9525817 chr13:44225189 C/T cg26741380 chr15:41871084 TYRO3 0.48 6.59 0.34 1.79e-10 Response to tocilizumab in rheumatoid arthritis; CRC cis rs1552244 0.882 rs13062917 chr3:10017032 T/A cg18598329 chr3:10140678 FANCD2;C3orf24 -0.81 -10.69 -0.51 4.18e-23 Alzheimer's disease; CRC trans rs16846053 0.786 rs72873607 chr2:162471174 G/A cg12500891 chr11:57225987 NA -0.67 -6.03 -0.32 4.43e-9 Blood osmolality (transformed sodium); CRC cis rs11785693 0.909 rs62489557 chr8:4968371 A/G cg26367366 chr8:4980734 NA 0.84 10.01 0.48 9.15e-21 Neuroticism (multi-trait analysis);Neuroticism; CRC cis rs853679 0.517 rs9393897 chr6:28127710 G/T cg02683197 chr6:28174875 NA 0.87 10.73 0.51 3.25e-23 Depression; CRC cis rs10791323 0.602 rs7946895 chr11:133733893 T/C cg15485101 chr11:133734466 NA 0.48 8.62 0.43 2.93e-16 Childhood ear infection; CRC cis rs7772486 0.754 rs6915718 chr6:146100676 A/G cg23711669 chr6:146136114 FBXO30 -0.77 -13.24 -0.59 2.33e-32 Lobe attachment (rater-scored or self-reported); CRC cis rs2386661 0.547 rs4747358 chr10:5650193 A/G cg26603656 chr10:5671107 NA -0.45 -7.41 -0.38 1.08e-12 Breast cancer; CRC cis rs6582630 0.555 rs10880612 chr12:38509427 A/G cg26384229 chr12:38710491 ALG10B 0.71 10.1 0.49 4.6e-21 Drug-induced liver injury (flucloxacillin); CRC cis rs875971 0.928 rs6970357 chr7:65968878 T/C cg00343986 chr7:65444356 GUSB 0.44 6.47 0.34 3.56e-10 Aortic root size; CRC cis rs1218582 0.772 rs10908445 chr1:154849590 A/G cg09359103 chr1:154839909 KCNN3 0.77 14.07 0.61 1.57e-35 Prostate cancer; CRC cis rs6693567 0.545 rs2275246 chr1:150460168 A/G cg15654264 chr1:150340011 RPRD2 0.39 5.78 0.3 1.77e-8 Migraine; CRC cis rs7306456 0.623 rs10902513 chr12:132693487 A/G cg07640336 chr12:132677496 NA 0.45 8.01 0.4 2.02e-14 Anti-saccade response; CRC cis rs7772486 0.817 rs2144477 chr6:146406248 C/T cg23711669 chr6:146136114 FBXO30 0.66 11.56 0.54 3.61e-26 Lobe attachment (rater-scored or self-reported); CRC cis rs4713118 0.955 rs9468206 chr6:27690453 G/T cg12172441 chr6:28176163 NA 0.48 6.27 0.33 1.11e-9 Parkinson's disease; CRC trans rs116095464 0.558 rs10080225 chr5:232175 A/G cg00938859 chr5:1591904 SDHAP3 0.69 7.58 0.39 3.49e-13 Breast cancer; CRC cis rs6867032 1.000 rs10462750 chr5:2012963 A/G cg26168224 chr5:2018326 NA 0.96 17.17 0.69 1.29e-47 Gut microbiome composition (winter); CRC cis rs10193935 0.901 rs10170082 chr2:42623452 T/C cg27598129 chr2:42591480 NA -0.68 -7.84 -0.4 6.51e-14 Colonoscopy-negative controls vs population controls; CRC cis rs1218582 0.741 rs4339857 chr1:154888962 A/G cg03351412 chr1:154909251 PMVK 0.55 8.85 0.44 5.5e-17 Prostate cancer; CRC cis rs1190545 0.588 rs4906213 chr14:102991021 C/T cg18135206 chr14:102964638 TECPR2 0.56 7.34 0.38 1.71e-12 Platelet count; CRC cis rs9487051 0.714 rs7774377 chr6:109602443 G/A cg01475377 chr6:109611718 NA -0.4 -6.99 -0.36 1.53e-11 Reticulocyte fraction of red cells; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg20470275 chr5:122180934 SNX24 0.44 6.56 0.34 2.09e-10 Intelligence (multi-trait analysis); CRC cis rs7584330 0.657 rs7599658 chr2:238352898 A/C cg14458575 chr2:238380390 NA -0.72 -12.48 -0.57 1.51e-29 Prostate cancer; CRC trans rs208520 0.754 rs7753158 chr6:66875633 A/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.98 -13.07 -0.58 9.65e-32 Exhaled nitric oxide output; CRC cis rs10751667 0.666 rs7396509 chr11:956761 G/A cg06064525 chr11:970664 AP2A2 -0.3 -6.13 -0.32 2.47e-9 Alzheimer's disease (late onset); CRC cis rs250677 0.652 rs250670 chr5:148446646 G/T cg18129178 chr5:148520854 ABLIM3 -0.36 -5.66 -0.3 3.32e-8 Breast cancer; CRC cis rs6732160 0.564 rs2043096 chr2:73375723 T/C cg01422370 chr2:73384389 NA 0.37 5.75 0.3 2.09e-8 Intelligence (multi-trait analysis); CRC cis rs9612 1.000 rs12669 chr19:44235535 G/A cg08581076 chr19:44259116 C19orf61 0.54 6.71 0.35 8.6e-11 Exhaled nitric oxide output; CRC cis rs2949837 0.581 rs1117457 chr7:45970037 G/A cg06713098 chr7:45960367 IGFBP3 0.41 6.51 0.34 2.73e-10 Sitting height ratio; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg11958594 chr17:80055299 FASN 0.46 6.79 0.35 5.37e-11 Response to antipsychotic treatment; CRC cis rs344364 0.511 rs1657144 chr16:1963989 C/A cg03013636 chr16:1946785 NA 0.55 6.67 0.35 1.1e-10 Glomerular filtration rate in chronic kidney disease; CRC trans rs9956878 0.555 rs8085188 chr18:73544676 A/G cg02834722 chr3:129830330 LOC729375 -0.39 -6.26 -0.33 1.18e-9 Obesity-related traits; CRC cis rs4423214 1.000 rs2282620 chr11:71183477 C/T cg05163923 chr11:71159392 DHCR7 0.66 9.3 0.46 2.04e-18 Vitamin D levels; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg07631383 chr7:131012765 MKLN1 0.54 7.69 0.39 1.68e-13 Response to antipsychotic treatment; CRC cis rs9583531 0.600 rs3809344 chr13:111358705 G/A cg24331049 chr13:111365604 ING1 0.57 7.92 0.4 3.6e-14 Coronary artery disease; CRC cis rs2124969 0.506 rs62175396 chr2:161043603 G/A cg03641300 chr2:160917029 PLA2R1 -0.63 -8.06 -0.41 1.47e-14 Waist circumference adjusted for body mass index; CRC trans rs4263408 0.934 rs9683743 chr4:39703194 A/C cg00628130 chr8:95908808 CCNE2 -0.46 -7.0 -0.36 1.47e-11 Plasma amyloid beta peptide concentrations (ABx-40); CRC trans rs2014572 0.933 rs8109882 chr19:57755618 C/G cg02674126 chr19:40336878 FBL 0.43 6.89 0.36 2.84e-11 Hyperactive-impulsive symptoms; CRC cis rs72615157 0.634 rs74774557 chr7:99810425 A/G cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.59 6.89 0.35 2.92e-11 Lung function (FEV1/FVC); CRC cis rs185694 1.000 rs672233 chr13:30899601 G/A cg04551440 chr13:30881194 KATNAL1 -0.61 -6.32 -0.33 8.68e-10 Antineutrophil cytoplasmic antibody-associated vasculitis; CRC cis rs1218582 0.772 rs6686873 chr1:154913404 C/G cg03351412 chr1:154909251 PMVK 0.54 8.61 0.43 3.17e-16 Prostate cancer; CRC cis rs617791 0.530 rs7952056 chr11:65744597 C/T cg09783858 chr11:65769428 EIF1AD;BANF1 0.47 7.15 0.37 5.81e-12 Breast cancer; CRC cis rs1448094 0.512 rs7313278 chr12:86250263 C/T cg18827107 chr12:86230957 RASSF9 -0.45 -7.49 -0.38 6.6e-13 Major depressive disorder; CRC cis rs7605827 0.897 rs10929371 chr2:15662299 A/G cg19274914 chr2:15703543 NA 0.39 5.87 0.31 1.07e-8 Educational attainment (years of education); CRC cis rs1799949 0.965 rs11650132 chr17:41326087 T/G cg01879757 chr17:41196368 BRCA1 -0.4 -5.97 -0.31 6.11e-9 Menopause (age at onset); CRC cis rs17401966 0.838 rs12120191 chr1:10345772 A/G cg19773385 chr1:10388646 KIF1B -0.67 -11.12 -0.52 1.33e-24 Hepatocellular carcinoma; CRC cis rs17443541 0.507 rs6726848 chr2:200451027 G/A cg03741458 chr2:200468445 NA -0.38 -5.95 -0.31 6.72e-9 Intelligence (multi-trait analysis); CRC cis rs10857712 0.754 rs1052582 chr10:135233840 C/G cg19623624 chr10:135278901 LOC619207 -0.35 -5.75 -0.3 2.04e-8 Systemic lupus erythematosus; CRC cis rs7591163 1.000 rs4300818 chr2:228713255 G/T cg00063174 chr2:228736253 WDR69 -0.51 -6.86 -0.35 3.49e-11 Blood pressure; CRC cis rs7927771 0.965 rs34958982 chr11:47547046 T/C cg20307385 chr11:47447363 PSMC3 -0.56 -7.81 -0.4 7.68e-14 Subjective well-being; CRC trans rs45509595 0.841 rs200485 chr6:27775697 G/C cg06606381 chr12:133084897 FBRSL1 -0.75 -6.49 -0.34 3.15e-10 Breast cancer; CRC trans rs951252 0.504 rs11734405 chr4:146081096 C/T cg22746681 chr10:51912631 NA -0.37 -6.12 -0.32 2.65e-9 Hip circumference; CRC cis rs2075371 0.829 rs35897155 chr7:134002711 G/A cg02659138 chr7:134003124 SLC35B4 0.41 6.81 0.35 4.57e-11 Mean platelet volume; CRC cis rs4713118 0.513 rs149989 chr6:27998184 T/A cg15786705 chr6:28176104 NA 0.59 8.64 0.43 2.46e-16 Parkinson's disease; CRC cis rs3820068 0.581 rs56128111 chr1:15928948 T/G cg13390004 chr1:15929781 NA 0.51 7.2 0.37 4.22e-12 Systolic blood pressure; CRC cis rs6724607 0.905 rs7603849 chr2:191438741 A/C cg27211696 chr2:191398769 TMEM194B 0.41 6.05 0.32 3.95e-9 Pulse pressure; CRC cis rs826838 1.000 rs11169031 chr12:39056738 T/C cg13010199 chr12:38710504 ALG10B 0.44 5.82 0.31 1.4e-8 Heart rate; CRC cis rs1799949 1.000 rs8070085 chr17:41341984 C/T cg01879757 chr17:41196368 BRCA1 0.39 5.97 0.31 6.26e-9 Menopause (age at onset); CRC cis rs6496667 0.779 rs62020687 chr15:90954396 C/T cg04176472 chr15:90893244 GABARAPL3 0.63 8.16 0.41 7.15e-15 Rheumatoid arthritis; CRC cis rs7107174 0.681 rs10751288 chr11:78072658 A/T cg02023728 chr11:77925099 USP35 0.49 7.47 0.38 7.48e-13 Testicular germ cell tumor; CRC cis rs208520 0.690 rs851465 chr6:66840293 G/A cg07460842 chr6:66804631 NA -1.1 -15.04 -0.64 2.83e-39 Exhaled nitric oxide output; CRC cis rs6570726 0.846 rs6570700 chr6:145931552 A/G cg23711669 chr6:146136114 FBXO30 0.65 10.72 0.51 3.37e-23 Lobe attachment (rater-scored or self-reported); CRC cis rs4727027 0.866 rs3735311 chr7:148877737 T/C cg12479418 chr7:148823350 ZNF425;ZNF398 0.42 5.86 0.31 1.14e-8 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg07555343 chr3:176669833 NA -0.36 -6.81 -0.35 4.62e-11 Obesity-related traits; CRC cis rs6570726 0.791 rs418701 chr6:145889992 C/T cg05347473 chr6:146136440 FBXO30 0.38 5.85 0.31 1.18e-8 Lobe attachment (rater-scored or self-reported); CRC cis rs7586879 0.639 rs7567997 chr2:25096952 A/G cg04586622 chr2:25135609 ADCY3 -0.54 -10.29 -0.49 1.04e-21 Body mass index; CRC cis rs2979489 0.891 rs2979511 chr8:30394968 G/A cg26383811 chr8:30366931 RBPMS -0.69 -10.01 -0.48 9.16e-21 Mean corpuscular hemoglobin;Plateletcrit;Neutrophil count;Granulocyte count;Sum basophil neutrophil counts;Mean corpuscular volume;Myeloid white cell count;Sum neutrophil eosinophil counts; CRC cis rs514406 0.861 rs562182 chr1:53270010 C/T cg25767906 chr1:53392781 SCP2 -0.48 -7.49 -0.38 6.3e-13 Monocyte count; CRC cis rs8078723 0.966 rs7021 chr17:38153875 T/A cg17344932 chr17:38183730 MED24;SNORD124 -0.45 -6.92 -0.36 2.31e-11 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); CRC cis rs1355223 1.000 rs1355222 chr11:34758716 C/G cg11058730 chr11:34937778 PDHX;APIP -0.43 -6.0 -0.31 5.26e-9 Systemic lupus erythematosus and Systemic sclerosis; CRC cis rs9902453 0.765 rs2127001 chr17:28098219 G/T cg26525008 chr17:28256777 EFCAB5;SSH2 -0.72 -12.16 -0.56 2.33e-28 Coffee consumption (cups per day); CRC cis rs10540 0.818 rs12806089 chr11:501468 G/A cg03352830 chr11:487213 PTDSS2 0.67 7.71 0.39 1.48e-13 Body mass index; CRC cis rs9372498 0.505 rs62424173 chr6:118780507 C/G cg22561889 chr6:118971681 C6orf204 0.52 6.7 0.35 9.08e-11 Diastolic blood pressure; CRC cis rs11190604 0.945 rs7091356 chr10:102292268 G/C cg07080220 chr10:102295463 HIF1AN 0.47 5.65 0.3 3.39e-8 Palmitoleic acid (16:1n-7) levels; CRC cis rs3741404 0.584 rs645461 chr11:63893694 C/T cg15107132 chr11:63991130 FERMT3 0.38 6.28 0.33 1.05e-9 Platelet count; CRC cis rs13191362 1.000 rs13193282 chr6:163015442 T/C cg21926612 chr6:163149169 PACRG;PARK2 0.79 10.93 0.52 6.15e-24 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs116095464 0.558 rs7356535 chr5:284117 G/T cg22496380 chr5:211416 CCDC127 -0.98 -9.75 -0.47 6.54e-20 Breast cancer; CRC cis rs2949837 0.581 rs1117457 chr7:45970037 G/A cg15898840 chr7:45960834 IGFBP3 0.43 7.07 0.36 9.17e-12 Sitting height ratio; CRC cis rs9303280 0.806 rs10445308 chr17:37938047 C/T cg17344932 chr17:38183730 MED24;SNORD124 0.34 5.64 0.3 3.76e-8 Self-reported allergy; CRC cis rs2882667 0.755 rs55650316 chr5:138467292 C/G cg04439458 chr5:138467593 SIL1 -0.38 -6.49 -0.34 3.23e-10 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs7259376 0.875 rs2116919 chr19:22491706 C/G cg02657401 chr19:22469223 NA -0.36 -7.92 -0.4 3.7e-14 Menopause (age at onset); CRC cis rs6951245 1.000 rs79765398 chr7:1073764 A/G cg04025307 chr7:1156635 C7orf50 0.64 6.69 0.35 9.59e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs6502050 0.835 rs62078304 chr17:80085224 G/A cg02741985 chr17:80059408 CCDC57 -0.44 -7.18 -0.37 4.75e-12 Life satisfaction; CRC cis rs6762 0.719 rs28620453 chr11:836971 G/C cg03885332 chr11:832357 CD151 -0.43 -6.4 -0.33 5.29e-10 Mean platelet volume; CRC trans rs1422110 0.543 rs768240 chr5:85420954 C/T cg01787110 chr1:109008453 NBPF6 -0.41 -5.97 -0.31 6.05e-9 Attention function in attention deficit hyperactive disorder; CRC cis rs66782572 1 rs66782572 chr3:52567617 A/G cg18099408 chr3:52552593 STAB1 -0.59 -11.34 -0.53 2.27e-25 Hemoglobin concentration; CRC cis rs66782572 1 rs66782572 chr3:52567617 A/G cg18591801 chr3:52553433 STAB1 -0.3 -5.79 -0.3 1.66e-8 Hemoglobin concentration; CRC trans rs6550704 0.687 rs9865314 chr3:22634337 A/G cg04212729 chr14:65171037 PLEKHG3 -0.44 -6.51 -0.34 2.83e-10 Daytime sleep phenotypes; CRC trans rs2303319 0.504 rs62187646 chr2:162445488 T/C cg18122310 chr12:50236657 BCDIN3D -0.74 -6.19 -0.32 1.81e-9 Cognitive function; CRC cis rs6460942 0.915 rs2192842 chr7:12315752 C/G cg20607287 chr7:12443886 VWDE -0.5 -6.73 -0.35 7.33e-11 Coronary artery disease; CRC cis rs79387448 0.745 rs1403549 chr2:103110745 G/C cg09003973 chr2:102972529 NA 0.67 7.23 0.37 3.36e-12 Gut microbiota (bacterial taxa); CRC cis rs7809950 1.000 rs986994 chr7:107104115 G/T cg23024343 chr7:107201750 COG5 -0.61 -8.92 -0.44 3.31e-17 Coronary artery disease; CRC cis rs7208859 0.623 rs73269916 chr17:29096326 A/G cg01831904 chr17:28903510 LRRC37B2 -0.63 -6.51 -0.34 2.77e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs1355223 0.583 rs2941044 chr11:34867444 A/C cg24088639 chr11:34937564 PDHX;APIP -0.58 -8.44 -0.42 9.95e-16 Systemic lupus erythematosus and Systemic sclerosis; CRC cis rs10751667 0.600 rs1128413 chr11:1010694 C/T ch.11.42038R chr11:967971 AP2A2 0.56 8.88 0.44 4.54e-17 Alzheimer's disease (late onset); CRC cis rs4819052 0.851 rs2838855 chr21:46680566 C/G cg11663144 chr21:46675770 NA 0.84 14.66 0.63 8.66e-38 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs2281845 0.965 rs3738263 chr1:201083506 A/G cg22815214 chr1:201083145 CACNA1S 0.62 10.27 0.49 1.22e-21 Permanent tooth development; CRC cis rs4731207 0.698 rs6942933 chr7:124444522 C/T cg23710748 chr7:124431027 NA 0.37 5.96 0.31 6.53e-9 Cutaneous malignant melanoma; CRC cis rs7666738 0.830 rs13124904 chr4:98856973 T/C cg05340658 chr4:99064831 C4orf37 0.56 8.33 0.42 2.21e-15 Colonoscopy-negative controls vs population controls; CRC cis rs7666738 0.753 rs4699604 chr4:99056353 T/C cg17366294 chr4:99064904 C4orf37 0.44 7.33 0.37 1.76e-12 Colonoscopy-negative controls vs population controls; CRC cis rs9486715 0.867 rs2499775 chr6:97007340 C/T cg18709589 chr6:96969512 KIAA0776 -0.5 -7.39 -0.38 1.25e-12 Headache; CRC cis rs3764400 0.567 rs2229369 chr17:46136133 G/C cg10706073 chr17:46328419 SKAP1 -0.68 -7.09 -0.36 8.08e-12 Body mass index; CRC cis rs7633770 0.735 rs12491294 chr3:46688498 G/T cg11219411 chr3:46661640 NA -0.39 -5.74 -0.3 2.13e-8 Coronary artery disease; CRC trans rs2303319 0.504 rs62187656 chr2:162487699 A/G cg25193742 chr10:104614220 C10orf32 -0.73 -5.97 -0.31 6.18e-9 Cognitive function; CRC cis rs7843479 0.562 rs4872191 chr8:21824547 A/G cg16476235 chr8:21771668 DOK2 0.37 6.24 0.33 1.36e-9 Mean corpuscular volume; CRC cis rs8031584 0.678 rs4779790 chr15:31164595 T/C cg08109568 chr15:31115862 NA -0.68 -10.65 -0.51 5.97e-23 Huntington's disease progression; CRC cis rs3806843 1.000 rs6898939 chr5:140169355 C/A cg16607685 chr5:140181889 PCDHA2;PCDHA1;PCDHA3 -0.27 -6.25 -0.33 1.26e-9 Depressive symptoms (multi-trait analysis); CRC cis rs7662987 0.517 rs1377689 chr4:100021787 A/G cg13256891 chr4:100009986 ADH5 0.63 8.56 0.43 4.54e-16 Smoking initiation; CRC cis rs8072100 0.840 rs9912311 chr17:45547132 T/C cg08085267 chr17:45401833 C17orf57 -0.66 -10.9 -0.52 7.97e-24 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs11971779 0.680 rs10085901 chr7:139108989 G/A cg07862535 chr7:139043722 LUC7L2 0.57 7.32 0.37 1.92e-12 Diisocyanate-induced asthma; CRC cis rs708547 0.830 rs1713994 chr4:57868367 G/A cg25525207 chr4:57843836 C4orf14;POLR2B -0.54 -7.54 -0.38 4.54e-13 Response to bleomycin (chromatid breaks); CRC cis rs6840360 0.571 rs11723395 chr4:152524191 G/A cg09659197 chr4:152720779 NA 0.32 5.78 0.3 1.74e-8 Intelligence (multi-trait analysis); CRC cis rs9467711 0.591 rs13208859 chr6:25894609 G/A cg12315302 chr6:26189340 HIST1H4D 0.8 6.44 0.33 4.14e-10 Autism spectrum disorder or schizophrenia; CRC cis rs7833986 1.000 rs36088882 chr8:57092914 T/A cg23139584 chr8:56987506 RPS20;SNORD54 0.61 7.54 0.38 4.64e-13 Height; CRC cis rs10504229 0.593 rs80174614 chr8:58024631 G/A cg21724239 chr8:58056113 NA 0.58 7.75 0.39 1.17e-13 Developmental language disorder (linguistic errors); CRC trans rs1642645 0.831 rs11210563 chr1:42494633 G/T cg16926213 chr1:1841314 NA -0.43 -6.11 -0.32 2.8e-9 Left ventricular obstructive tract defect (maternal effect); CRC cis rs4803455 0.565 rs1025497 chr19:41871254 A/G cg09537434 chr19:41945824 ATP5SL -0.6 -8.94 -0.44 2.93e-17 Migraine;Coronary artery disease; CRC cis rs3736485 0.966 rs2414111 chr15:51901357 A/G cg08986416 chr15:51914746 DMXL2 0.45 6.34 0.33 7.55e-10 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs9372498 0.536 rs17080292 chr6:118850266 A/G cg18833306 chr6:118973337 C6orf204 0.45 5.96 0.31 6.57e-9 Diastolic blood pressure; CRC cis rs250677 0.958 rs36068 chr5:148417512 C/T cg23229984 chr5:148520753 ABLIM3 0.5 6.82 0.35 4.28e-11 Breast cancer; CRC cis rs2062225 1.000 rs1157083 chr2:111754921 C/T cg11729679 chr2:111877065 BCL2L11 -0.56 -5.64 -0.3 3.67e-8 Monocyte count; CRC cis rs9611565 0.512 rs139562 chr22:42196684 G/C cg03806693 chr22:41940476 POLR3H -1.1 -13.54 -0.6 1.6e-33 Vitiligo; CRC cis rs7918232 0.941 rs788220 chr10:27447205 T/C cg14442939 chr10:27389572 ANKRD26 -0.83 -9.09 -0.45 9.52e-18 Breast cancer; CRC cis rs4889855 1.000 rs4889855 chr17:78513280 G/A cg16591659 chr17:78472290 NA -0.63 -6.98 -0.36 1.62e-11 Fractional excretion of uric acid; CRC cis rs7937682 0.889 rs497111 chr11:111499512 G/A cg19812747 chr11:111475976 SIK2 -0.57 -9.74 -0.47 7.45e-20 Primary sclerosing cholangitis; CRC cis rs10927875 0.632 rs6699394 chr1:16145143 C/A cg21385522 chr1:16154831 NA -1.1 -20.02 -0.74 7.19e-59 Dilated cardiomyopathy; CRC cis rs12188164 0.965 rs56146525 chr5:442571 A/C cg26850624 chr5:429559 AHRR -0.8 -13.22 -0.59 2.8e-32 Cystic fibrosis severity; CRC cis rs9311474 0.607 rs11711421 chr3:52561779 C/T cg11645453 chr3:52864694 ITIH4 0.34 6.2 0.32 1.72e-9 Electroencephalogram traits; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg07243161 chr6:136871709 MAP7 0.44 6.2 0.32 1.68e-9 Anxiety disorder; CRC cis rs56775891 0.959 rs7238071 chr18:77579812 C/T cg24058013 chr18:77568902 NA 0.43 6.99 0.36 1.58e-11 Schizophrenia; CRC cis rs863345 0.604 rs12044283 chr1:158463833 C/T cg12129480 chr1:158549410 OR10X1 -0.3 -6.26 -0.33 1.17e-9 Pneumococcal bacteremia; CRC cis rs6484504 0.532 rs1929019 chr11:31267030 C/T cg14844989 chr11:31128820 NA -0.33 -5.84 -0.31 1.23e-8 Red blood cell count; CRC cis rs7772486 0.754 rs697054 chr6:146003770 C/T cg05347473 chr6:146136440 FBXO30 0.42 6.38 0.33 6.17e-10 Lobe attachment (rater-scored or self-reported); CRC cis rs769267 0.930 rs751856 chr19:19602945 A/G cg02546618 chr19:19431379 KIAA0892;SF4 0.45 6.13 0.32 2.46e-9 Tonsillectomy; CRC trans rs1908814 0.516 rs11250178 chr8:11800234 A/C cg06636001 chr8:8085503 FLJ10661 0.48 7.06 0.36 9.65e-12 Neuroticism; CRC cis rs9611565 0.512 rs2899349 chr22:42164660 T/C cg06481639 chr22:41940642 POLR3H 0.56 6.19 0.32 1.75e-9 Vitiligo; CRC cis rs2836974 0.565 rs2836939 chr21:40578546 C/T cg11890956 chr21:40555474 PSMG1 0.72 8.09 0.41 1.12e-14 Cognitive function; CRC cis rs35306767 0.807 rs34885925 chr10:919032 G/C cg20503657 chr10:835505 NA 1.21 14.83 0.63 1.78e-38 Eosinophil percentage of granulocytes; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg24506767 chr6:52264762 PAQR8 0.43 6.34 0.33 7.42e-10 Thyroid stimulating hormone; CRC cis rs8031584 0.560 rs7171208 chr15:31198929 A/G cg08109568 chr15:31115862 NA 0.41 6.59 0.34 1.75e-10 Huntington's disease progression; CRC trans rs7395662 0.963 rs6485900 chr11:48637415 C/T cg21153622 chr11:89784906 NA -0.48 -7.76 -0.39 1.07e-13 HDL cholesterol; CRC cis rs3008870 0.583 rs11208978 chr1:67442210 C/T cg08660285 chr1:67390436 MIER1;WDR78 -1.02 -12.41 -0.56 2.97e-29 Lymphocyte percentage of white cells; CRC cis rs1799949 0.965 rs8176310 chr17:41199913 T/C cg25072359 chr17:41440525 NA 0.5 7.92 0.4 3.8e-14 Menopause (age at onset); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg24225281 chr7:99097483 ZNF394 0.52 7.46 0.38 7.56e-13 Response to antipsychotic treatment; CRC cis rs11098499 0.863 rs3775841 chr4:120425777 A/C cg24375607 chr4:120327624 NA 0.46 6.94 0.36 2.09e-11 Corneal astigmatism; CRC cis rs13191362 0.935 rs34141091 chr6:162953893 T/A cg21926612 chr6:163149169 PACRG;PARK2 0.81 10.03 0.48 7.81e-21 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs9858542 1.000 rs11709525 chr3:49690496 C/T cg07274523 chr3:49395745 GPX1 0.45 5.69 0.3 2.88e-8 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC trans rs1814175 0.645 rs6486022 chr11:49776137 A/G cg03929089 chr4:120376271 NA -0.92 -16.19 -0.67 9.24e-44 Height; CRC cis rs7191439 0.583 rs9935872 chr16:88788477 A/G cg02389323 chr16:88786976 FAM38A 0.82 7.67 0.39 1.95e-13 Plateletcrit; CRC cis rs1355223 0.525 rs10836316 chr11:34874295 C/T cg11058730 chr11:34937778 PDHX;APIP -0.43 -6.07 -0.32 3.51e-9 Systemic lupus erythematosus and Systemic sclerosis; CRC cis rs17376456 0.825 rs56108532 chr5:93276342 C/T cg25358565 chr5:93447407 FAM172A 1.08 10.82 0.51 1.46e-23 Diabetic retinopathy; CRC cis rs3772130 0.962 rs11706783 chr3:121534322 T/C cg20356878 chr3:121714668 ILDR1 0.51 7.94 0.4 3.22e-14 Cognitive performance; CRC cis rs8072100 0.576 rs12948299 chr17:45403057 T/C cg08085267 chr17:45401833 C17orf57 -0.73 -11.3 -0.53 2.95e-25 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs67478160 0.595 rs2295146 chr14:104199356 C/T cg01849466 chr14:104193079 ZFYVE21 -0.53 -9.16 -0.45 5.69e-18 Schizophrenia; CRC cis rs524281 0.814 rs10896093 chr11:65958411 C/G cg16950941 chr11:66035639 RAB1B -0.6 -7.46 -0.38 7.7e-13 Electroencephalogram traits; CRC trans rs11722228 0.549 rs73212828 chr4:10078756 C/T cg26043149 chr18:55253948 FECH 1.12 16.96 0.68 8.7e-47 Gout;Urate levels;Serum uric acid levels; CRC cis rs7312933 0.933 rs4534650 chr12:42444222 A/G cg01256987 chr12:42539512 GXYLT1 -0.44 -6.62 -0.34 1.45e-10 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CRC cis rs748404 0.697 rs473554 chr15:43568207 C/T cg02155558 chr15:43621948 ADAL;LCMT2 0.43 6.37 0.33 6.54e-10 Lung cancer; CRC cis rs3820068 0.603 rs6668726 chr1:15962614 G/A cg13390004 chr1:15929781 NA 0.5 7.06 0.36 1.02e-11 Systolic blood pressure; CRC cis rs7589728 0.563 rs75606549 chr2:88466069 T/C cg24977027 chr2:88469347 THNSL2 0.63 7.75 0.39 1.14e-13 Plasma clusterin levels; CRC cis rs1044826 0.518 rs295488 chr3:139239323 C/T cg15131784 chr3:139108705 COPB2 0.52 7.42 0.38 1.01e-12 Obesity-related traits; CRC cis rs4727027 0.933 rs6955564 chr7:148866173 A/G cg12479418 chr7:148823350 ZNF425;ZNF398 0.43 5.87 0.31 1.08e-8 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC cis rs6456156 0.774 rs2021999 chr6:167529766 G/C cg07513332 chr6:167530253 CCR6 -0.48 -8.72 -0.43 1.39e-16 Primary biliary cholangitis; CRC cis rs7493 0.853 rs35686517 chr7:95052611 G/A cg19678392 chr7:94953810 PON1 -0.6 -7.35 -0.38 1.54e-12 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs72945132 0.825 rs2298411 chr11:70206046 G/A cg00319359 chr11:70116639 PPFIA1 0.6 6.73 0.35 7.72e-11 Coronary artery disease; CRC cis rs8180040 0.620 rs9844122 chr3:47108330 C/T cg02527881 chr3:46936655 PTH1R -0.34 -5.92 -0.31 7.94e-9 Colorectal cancer; CRC cis rs736408 0.677 rs678 chr3:52820981 A/T cg07507251 chr3:52567010 NT5DC2 0.46 6.41 0.33 5.15e-10 Bipolar disorder; CRC cis rs10927875 0.632 rs4481843 chr1:16128205 G/A cg21385522 chr1:16154831 NA -1.07 -17.38 -0.69 1.88e-48 Dilated cardiomyopathy; CRC cis rs7772486 0.686 rs1045820 chr6:145947080 C/T cg13319975 chr6:146136371 FBXO30 -0.43 -6.36 -0.33 6.57e-10 Lobe attachment (rater-scored or self-reported); CRC cis rs7927771 0.864 rs55927797 chr11:47446292 A/T cg20307385 chr11:47447363 PSMC3 -0.62 -9.08 -0.45 1.01e-17 Subjective well-being; CRC cis rs2404602 0.684 rs1603860 chr15:76849591 A/T cg23625390 chr15:77176239 SCAPER -0.86 -14.21 -0.62 4.44e-36 Blood metabolite levels; CRC cis rs9467711 0.606 rs9379897 chr6:26601526 T/C cg12315302 chr6:26189340 HIST1H4D 0.76 6.0 0.31 5.23e-9 Autism spectrum disorder or schizophrenia; CRC cis rs3790455 0.585 rs3790460 chr1:156465029 C/G cg14087168 chr1:156450669 MEF2D -0.37 -6.1 -0.32 2.91e-9 Migraine; CRC cis rs2415984 0.622 rs7156444 chr14:46933296 C/G cg14871534 chr14:47121158 RPL10L -0.42 -5.97 -0.31 6.01e-9 Number of children ever born; CRC cis rs317689 0.581 rs160829 chr12:69769538 G/C cg14784868 chr12:69753453 YEATS4 0.65 8.9 0.44 3.78e-17 Response to diuretic therapy; CRC trans rs877282 0.898 rs11253339 chr10:759640 C/T cg22713356 chr15:30763199 NA 1.24 14.68 0.63 6.86e-38 Uric acid levels; CRC cis rs2380220 1.000 rs2380220 chr6:95967412 T/C cg07718321 chr6:96025334 MANEA 0.51 6.06 0.32 3.7e-9 Behavioural disinhibition (generation interaction); CRC trans rs3733585 0.648 rs13103497 chr4:9979262 A/G cg26043149 chr18:55253948 FECH 0.49 7.49 0.38 6.5e-13 Cleft plate (environmental tobacco smoke interaction); CRC cis rs736408 0.688 rs2239551 chr3:52818579 A/G cg15147215 chr3:52552868 STAB1 0.6 9.63 0.47 1.63e-19 Bipolar disorder; CRC cis rs7666738 0.830 rs6833312 chr4:98951356 A/T cg05340658 chr4:99064831 C4orf37 0.61 9.54 0.47 3.45e-19 Colonoscopy-negative controls vs population controls; CRC cis rs9467773 0.620 rs3800303 chr6:26598188 A/G cg09904177 chr6:26538194 HMGN4 0.73 11.56 0.54 3.47e-26 Intelligence (multi-trait analysis); CRC cis rs2836950 0.545 rs11701805 chr21:40618683 T/C cg17971929 chr21:40555470 PSMG1 -0.59 -8.54 -0.43 5.03e-16 Menarche (age at onset); CRC cis rs55702914 0.602 rs2564372 chr2:198307813 C/T cg10820045 chr2:198174542 NA 0.32 5.62 0.3 4.05e-8 Major depression and alcohol dependence; CRC cis rs6951245 0.745 rs79788515 chr7:1101079 C/T cg24642844 chr7:1081250 C7orf50 -0.76 -9.05 -0.45 1.29e-17 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs1153858 0.895 rs12593402 chr15:45617392 G/A cg10760299 chr15:45669010 GATM 0.53 8.09 0.41 1.14e-14 Homoarginine levels; CRC cis rs6942756 1.000 rs7803052 chr7:128959427 A/G cg02491457 chr7:128862824 NA -0.73 -9.8 -0.48 4.52e-20 White matter hyperintensity burden; CRC cis rs9926296 0.548 rs12447465 chr16:89829895 C/T cg27121462 chr16:89883253 FANCA 0.56 8.74 0.43 1.24e-16 Vitiligo; CRC cis rs870825 0.655 rs67798981 chr4:185619567 A/T cg04058563 chr4:185651563 MLF1IP 0.72 9.38 0.46 1.12e-18 Blood protein levels; CRC cis rs9323205 0.817 rs56100232 chr14:51699378 A/G cg23942311 chr14:51606299 NA -0.52 -6.19 -0.32 1.82e-9 Cancer; CRC cis rs6076065 0.676 rs1419005 chr20:23336432 G/T cg11657817 chr20:23433608 CST11 -0.45 -6.87 -0.35 3.19e-11 Facial morphology (factor 15, philtrum width); CRC cis rs8114671 0.527 rs6088650 chr20:33514465 C/T cg07148914 chr20:33460835 GGT7 -0.38 -6.2 -0.32 1.71e-9 Height; CRC cis rs77972916 0.505 rs1322 chr2:43521167 C/T cg06169590 chr2:43455088 ZFP36L2;LOC100129726 -0.66 -7.86 -0.4 5.52e-14 Granulocyte percentage of myeloid white cells; CRC cis rs78456975 0.657 rs116217838 chr2:1569173 T/C cg12573674 chr2:1569213 NA -0.82 -10.94 -0.52 5.57e-24 Placebo response in major depressive disorder (% change in symptom score); CRC cis rs7937682 0.889 rs493810 chr11:111491888 G/T cg19812747 chr11:111475976 SIK2 -0.59 -10.14 -0.49 3.31e-21 Primary sclerosing cholangitis; CRC cis rs6547741 1.000 rs4665381 chr2:27757150 A/C cg27432699 chr2:27873401 GPN1 0.77 13.73 0.6 3.16e-34 Oral cavity cancer; CRC cis rs9649213 0.593 rs6465683 chr7:98026092 C/A cg00277769 chr7:97922759 BAIAP2L1 -0.58 -9.94 -0.48 1.62e-20 Prostate cancer (SNP x SNP interaction); CRC cis rs2204008 0.682 rs2320517 chr12:38259239 A/T cg26384229 chr12:38710491 ALG10B 0.69 9.22 0.45 3.69e-18 Bladder cancer; CRC cis rs7914558 0.966 rs7908280 chr10:104816947 C/G cg04362960 chr10:104952993 NT5C2 0.6 9.1 0.45 8.54e-18 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs1448094 0.534 rs11613070 chr12:86167544 T/A cg00310523 chr12:86230176 RASSF9 0.4 6.52 0.34 2.6200000000000003e-10 Major depressive disorder; CRC trans rs35110281 0.805 rs2838317 chr21:44991791 A/C cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.45 7.47 0.38 7.34e-13 Mean corpuscular volume; CRC cis rs7666738 0.830 rs34890015 chr4:99023769 A/T cg05340658 chr4:99064831 C4orf37 0.61 9.35 0.46 1.39e-18 Colonoscopy-negative controls vs population controls; CRC cis rs6484504 0.576 rs208103 chr11:31167400 A/G cg14844989 chr11:31128820 NA -0.34 -5.93 -0.31 7.76e-9 Red blood cell count; CRC cis rs77861329 0.660 rs6778442 chr3:52148483 T/C cg08692210 chr3:52188851 WDR51A 0.55 6.26 0.33 1.23e-9 Macrophage inflammatory protein 1b levels; CRC cis rs6831352 1.000 rs6822348 chr4:100053894 A/T cg12011299 chr4:100065546 ADH4 0.53 10.81 0.51 1.67e-23 Alcohol dependence; CRC cis rs875971 0.545 rs316324 chr7:65610614 A/G cg03233332 chr7:66118400 NA 0.44 6.2 0.32 1.67e-9 Aortic root size; CRC cis rs9549328 0.800 rs1317507 chr13:113631780 G/T cg24588162 chr13:113633484 MCF2L -0.41 -7.36 -0.38 1.49e-12 Systolic blood pressure; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg24861191 chr19:2740086 SLC39A3 0.53 7.53 0.38 4.92e-13 Response to antipsychotic treatment; CRC cis rs9372498 0.505 rs62424204 chr6:118861642 G/A cg10217327 chr6:118973057 C6orf204 0.51 5.79 0.3 1.69e-8 Diastolic blood pressure; CRC cis rs117623576 0.941 rs17488859 chr10:32386072 A/G cg03047570 chr10:32398778 NA 0.68 6.94 0.36 2.09e-11 Anti-saccade response; CRC cis rs9768139 0.935 rs7809076 chr7:158118438 C/T cg24154853 chr7:158122151 PTPRN2 -0.59 -9.81 -0.48 4.14e-20 Calcium levels; CRC cis rs2075371 0.673 rs35290398 chr7:134011773 C/T cg11752832 chr7:134001865 SLC35B4 0.41 5.9 0.31 8.8e-9 Mean platelet volume; CRC cis rs4727963 0.792 rs10247666 chr7:122717198 A/G cg03640110 chr7:122635026 TAS2R16 -0.31 -5.73 -0.3 2.27e-8 Adverse response to chemotherapy (neutropenia/leucopenia) (docetaxel); CRC cis rs10769945 0.679 rs217213 chr11:1979118 C/G cg23202291 chr11:1979235 NA -0.5 -7.56 -0.38 4.17e-13 DNA methylation (variation); CRC cis rs270601 0.633 rs4535443 chr5:131572561 A/G cg18301423 chr5:131593218 PDLIM4 0.47 8.09 0.41 1.16e-14 Acylcarnitine levels; CRC cis rs9649213 0.593 rs6963210 chr7:97944986 G/A cg24562669 chr7:97807699 LMTK2 0.42 7.06 0.36 9.86e-12 Prostate cancer (SNP x SNP interaction); CRC cis rs2228479 0.717 rs34027607 chr16:89808939 T/C cg06558623 chr16:89946397 TCF25 0.84 8.8 0.44 7.89e-17 Skin colour saturation; CRC cis rs6461049 0.765 rs10224497 chr7:2149967 A/G cg02951883 chr7:2050386 MAD1L1 -0.56 -9.25 -0.45 2.91e-18 Schizophrenia; CRC cis rs60843830 1.000 rs36216559 chr2:262335 A/G cg25945732 chr2:264204 ACP1;SH3YL1 0.72 11.77 0.54 6.32e-27 Spherical equivalent (joint analysis main effects and education interaction); CRC cis rs7086627 0.515 rs7088877 chr10:82208860 C/G cg00277334 chr10:82204260 NA -0.84 -16.95 -0.68 9.58e-47 Post bronchodilator FEV1; CRC cis rs3806843 0.569 rs753279 chr5:140023818 A/G cg19875535 chr5:140030758 IK -0.53 -8.72 -0.43 1.39e-16 Depressive symptoms (multi-trait analysis); CRC cis rs826838 1.000 rs1719830 chr12:39096992 T/G cg26384229 chr12:38710491 ALG10B -0.6 -9.5 -0.46 4.58e-19 Heart rate; CRC cis rs2075371 1.000 rs1421486 chr7:133985196 T/C cg02659138 chr7:134003124 SLC35B4 0.37 6.41 0.33 5.15e-10 Mean platelet volume; CRC cis rs6088590 0.561 rs3891369 chr20:33161127 C/T cg08999081 chr20:33150536 PIGU 0.63 11.88 0.55 2.54e-27 Coronary artery disease; CRC cis rs2811415 0.597 rs13100212 chr3:127803657 G/A cg13719885 chr3:127795394 NA -0.4 -5.92 -0.31 8.11e-9 Lung function (FEV1/FVC); CRC cis rs8014204 0.566 rs752857 chr14:75130944 C/T cg03030879 chr14:75389066 RPS6KL1 -0.41 -6.38 -0.33 5.87e-10 Caffeine consumption; CRC cis rs6502050 0.799 rs6502089 chr17:80169523 G/A cg02741985 chr17:80059408 CCDC57 0.45 7.46 0.38 7.78e-13 Life satisfaction; CRC cis rs7412746 0.634 rs2124952 chr1:150923774 T/A cg15448220 chr1:150897856 SETDB1 0.56 8.23 0.41 4.44e-15 Melanoma; CRC cis rs6570726 0.846 rs4896824 chr6:145927048 C/T cg05347473 chr6:146136440 FBXO30 0.37 5.63 0.3 3.79e-8 Lobe attachment (rater-scored or self-reported); CRC trans rs1005277 0.579 rs2474563 chr10:38375938 T/C cg27523141 chr10:43048294 ZNF37B 0.5 7.29 0.37 2.29e-12 Extrinsic epigenetic age acceleration; CRC cis rs453301 0.686 rs11785634 chr8:8892597 G/T cg14979609 chr8:8086686 FLJ10661 0.38 6.27 0.33 1.13e-9 Joint mobility (Beighton score); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg11671925 chr11:67806426 TCIRG1 0.44 6.05 0.32 3.93e-9 Response to antipsychotic treatment; CRC cis rs812925 0.892 rs1186699 chr2:61662555 C/A cg10580144 chr2:61372316 C2orf74 0.3 6.13 0.32 2.48e-9 Immature fraction of reticulocytes; CRC cis rs17767392 1.000 rs17178206 chr14:71880093 A/G cg13720639 chr14:72061746 SIPA1L1 -0.55 -6.95 -0.36 1.96e-11 Mitral valve prolapse; CRC cis rs703842 1.000 rs10783847 chr12:58196447 G/A cg00677455 chr12:58241039 CTDSP2 0.67 9.42 0.46 8.41e-19 Multiple sclerosis; CRC cis rs28655083 0.529 rs645878 chr16:77099974 G/A cg01753188 chr16:77233325 SYCE1L;MON1B 0.48 6.81 0.35 4.54e-11 Lobe attachment (rater-scored or self-reported); CRC cis rs926938 0.584 rs6689326 chr1:115369112 T/A cg12756093 chr1:115239321 AMPD1 -0.57 -8.42 -0.42 1.17e-15 Autism; CRC cis rs501120 0.657 rs11238909 chr10:44688088 C/T cg09554077 chr10:44749378 NA 0.56 6.44 0.33 4.18e-10 Coronary artery disease;Coronary heart disease; CRC cis rs926392 0.533 rs6129162 chr20:37683195 G/A cg16355469 chr20:37678765 NA 0.48 7.16 0.37 5.17e-12 Dialysis-related mortality; CRC cis rs12586317 0.547 rs2383693 chr14:35500205 A/C cg16230307 chr14:35515116 FAM177A1 0.89 10.36 0.5 5.87e-22 Psoriasis; CRC cis rs16852403 0.583 rs1855174 chr1:178063040 G/A cg00404053 chr1:178313656 RASAL2 0.63 8.01 0.4 1.94e-14 Childhood ear infection; CRC cis rs270601 0.690 rs162907 chr5:131580152 A/G cg18758796 chr5:131593413 PDLIM4 -0.52 -9.01 -0.44 1.7e-17 Acylcarnitine levels; CRC cis rs9787249 0.915 rs58589165 chr1:40213670 A/T cg19912559 chr1:40204330 PPIE 0.52 7.68 0.39 1.82e-13 Blood protein levels; CRC trans rs2303319 0.504 rs56026147 chr2:162614089 T/C cg09481857 chr22:21368659 P2RX6;MGC16703 -0.65 -6.31 -0.33 9.13e-10 Cognitive function; CRC cis rs17209837 0.607 rs1558376 chr7:87079103 T/A cg00919237 chr7:87102261 ABCB4 -0.53 -7.07 -0.36 9.33e-12 Gallbladder cancer; CRC cis rs7552404 0.731 rs6699682 chr1:76340123 A/G cg10523679 chr1:76189770 ACADM -0.65 -8.04 -0.41 1.65e-14 Blood metabolite levels;Acylcarnitine levels; CRC trans rs703108 0.731 rs7898954 chr10:22323646 A/G cg14911708 chr12:114404314 RBM19 -0.54 -6.67 -0.35 1.09e-10 Monocyte percentage of white cells; CRC cis rs1799949 1.000 rs2070834 chr17:41242285 T/G cg25072359 chr17:41440525 NA 0.46 6.86 0.35 3.39e-11 Menopause (age at onset); CRC cis rs6712932 1.000 rs10170234 chr2:105841841 C/G cg22878388 chr2:105853796 NA -0.33 -6.41 -0.33 5.06e-10 Type 2 diabetes; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg00834779 chr19:12036415 ZNF700 0.47 7.08 0.36 9.01e-12 Intelligence (multi-trait analysis); CRC cis rs4363385 0.588 rs11205180 chr1:153022070 A/G cg25856811 chr1:152973957 SPRR3 -0.24 -6.54 -0.34 2.38e-10 Inflammatory skin disease; CRC cis rs3540 0.960 rs2238325 chr15:91011262 C/T cg22089800 chr15:90895588 ZNF774 -0.5 -8.11 -0.41 9.99e-15 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; CRC cis rs67311347 0.876 rs13068097 chr3:40504424 T/A cg09455208 chr3:40491958 NA -0.45 -9.18 -0.45 4.91e-18 Renal cell carcinoma; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg22650146 chr1:221915355 DUSP10 0.53 6.85 0.35 3.72e-11 Thyroid stimulating hormone; CRC cis rs7223966 1.000 rs55868506 chr17:61851686 T/G cg05941027 chr17:61774174 LIMD2 0.35 6.17 0.32 1.96e-9 Hip circumference adjusted for BMI;Body mass index; CRC cis rs9322193 0.923 rs9480031 chr6:150080011 A/C cg05861140 chr6:150128134 PCMT1 -0.39 -6.26 -0.33 1.21e-9 Lung cancer; CRC cis rs2976388 0.609 rs2585148 chr8:143796193 C/G cg05569086 chr8:143859399 LYNX1 0.38 6.74 0.35 7.06e-11 Urinary tract infection frequency; CRC cis rs875971 0.660 rs1860468 chr7:66107252 T/C cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.44 -6.44 -0.33 4.3e-10 Aortic root size; CRC cis rs10504229 0.679 rs11783444 chr8:58131267 A/G cg21724239 chr8:58056113 NA 0.49 6.81 0.35 4.75e-11 Developmental language disorder (linguistic errors); CRC cis rs1881797 0.872 rs12404733 chr1:247690417 A/C cg21399703 chr1:247681439 NA 0.46 7.76 0.39 1.06e-13 Acute lymphoblastic leukemia (childhood); CRC cis rs6951245 0.554 rs75075857 chr7:1140298 C/T cg22907277 chr7:1156413 C7orf50 0.81 10.52 0.5 1.63e-22 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs758324 0.812 rs6893957 chr5:131198780 T/C cg25547332 chr5:131281432 NA 0.35 5.61 0.3 4.19e-8 Alzheimer's disease in APOE e4- carriers; CRC cis rs870825 0.616 rs28579226 chr4:185650458 A/C cg04058563 chr4:185651563 MLF1IP 0.72 9.28 0.46 2.4e-18 Blood protein levels; CRC cis rs4665809 1.000 rs7588802 chr2:26277789 A/G cg26119090 chr2:26468346 HADHA;HADHB -0.62 -7.91 -0.4 3.86e-14 Gut microbiome composition (summer); CRC cis rs6570726 1.000 rs951143 chr6:145932576 C/T cg23711669 chr6:146136114 FBXO30 0.65 10.98 0.52 4.03e-24 Lobe attachment (rater-scored or self-reported); CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg22352186 chr4:1722180 TMEM129;TACC3 0.49 6.49 0.34 3.2e-10 Thyroid stimulating hormone; CRC cis rs9322193 0.923 rs9383812 chr6:150033491 C/T cg13206674 chr6:150067644 NUP43 0.66 10.02 0.48 8.65e-21 Lung cancer; CRC cis rs4727963 0.740 rs1404834 chr7:122715112 A/T cg03640110 chr7:122635026 TAS2R16 0.35 6.33 0.33 8.22e-10 Adverse response to chemotherapy (neutropenia/leucopenia) (docetaxel); CRC cis rs58688157 0.705 rs12800061 chr11:587425 C/A cg03909863 chr11:638404 DRD4 -0.51 -6.54 -0.34 2.35e-10 Systemic lupus erythematosus; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg00240809 chr16:8715546 C16orf68 0.45 6.25 0.33 1.27e-9 Anxiety disorder; CRC trans rs7395662 0.591 rs4882110 chr11:48558249 G/T cg00717180 chr2:96193071 NA -0.36 -6.0 -0.31 5.3e-9 HDL cholesterol; CRC cis rs8180040 0.966 rs12632132 chr3:47477019 C/T cg27129171 chr3:47204927 SETD2 0.52 7.94 0.4 3.32e-14 Colorectal cancer; CRC cis rs4711350 0.862 rs530614 chr6:33714781 G/A cg07979401 chr6:33739406 LEMD2 0.48 5.94 0.31 7.22e-9 Schizophrenia; CRC cis rs7917772 0.532 rs10748829 chr10:104527244 G/A cg11453585 chr10:104263688 ACTR1A;SUFU -0.68 -10.16 -0.49 2.94e-21 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC cis rs6502050 0.835 rs8081783 chr17:80117388 G/A cg13198984 chr17:80129470 CCDC57 0.46 8.18 0.41 6.3e-15 Life satisfaction; CRC cis rs754466 0.724 rs11002318 chr10:79633807 G/A cg26805224 chr10:79626177 DLG5 -0.55 -8.24 -0.41 4.24e-15 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs853679 0.517 rs2275508 chr6:28094731 T/C cg25164649 chr6:28176230 NA 0.75 9.41 0.46 8.75e-19 Depression; CRC cis rs28386778 0.897 rs8066754 chr17:61816590 T/C cg06873352 chr17:61820015 STRADA 0.75 13.96 0.61 4.22e-35 Prudent dietary pattern; CRC cis rs9649213 0.593 rs35535338 chr7:97962319 C/T cg24562669 chr7:97807699 LMTK2 0.44 7.29 0.37 2.33e-12 Prostate cancer (SNP x SNP interaction); CRC cis rs7772486 0.754 rs6906258 chr6:146089356 A/G cg23711669 chr6:146136114 FBXO30 -0.76 -13.05 -0.58 1.21e-31 Lobe attachment (rater-scored or self-reported); CRC cis rs938554 0.735 rs12498742 chr4:9944052 A/G cg00071950 chr4:10020882 SLC2A9 -0.44 -6.42 -0.33 4.69e-10 Blood metabolite levels; CRC cis rs11098499 0.662 rs13108589 chr4:120268102 G/C cg24375607 chr4:120327624 NA 0.5 7.84 0.4 6.19e-14 Corneal astigmatism; CRC cis rs7666738 0.830 rs4392515 chr4:98957431 A/G cg05340658 chr4:99064831 C4orf37 0.61 9.54 0.47 3.45e-19 Colonoscopy-negative controls vs population controls; CRC cis rs9649213 0.555 rs34695842 chr7:97931062 G/T cg21770322 chr7:97807741 LMTK2 0.52 8.48 0.42 7.81e-16 Prostate cancer (SNP x SNP interaction); CRC cis rs4713118 0.621 rs9295755 chr6:28033174 C/T cg02683197 chr6:28174875 NA -0.7 -8.65 -0.43 2.27e-16 Parkinson's disease; CRC cis rs4713118 0.784 rs9468219 chr6:27731755 C/A cg12172441 chr6:28176163 NA 0.55 7.14 0.37 5.96e-12 Parkinson's disease; CRC cis rs10791323 0.569 rs2282602 chr11:133714522 G/A cg03690763 chr11:133734501 NA -0.36 -5.9 -0.31 8.92e-9 Childhood ear infection; CRC cis rs6460942 0.749 rs62448592 chr7:12435985 A/T cg20607287 chr7:12443886 VWDE -0.66 -6.93 -0.36 2.22e-11 Coronary artery disease; CRC cis rs763121 0.626 rs5750643 chr22:39009017 A/G cg06544989 chr22:39130855 UNC84B 0.46 7.46 0.38 7.83e-13 Menopause (age at onset); CRC cis rs611744 0.647 rs1379336 chr8:109276606 G/T cg21045802 chr8:109455806 TTC35 0.43 6.83 0.35 4.05e-11 Dupuytren's disease; CRC cis rs11583043 0.872 rs1326380 chr1:101293753 G/T cg00063077 chr1:101360652 SLC30A7;EXTL2 0.48 6.4 0.33 5.33e-10 Ulcerative colitis;Inflammatory bowel disease; CRC cis rs78545713 0.536 rs116337444 chr6:26208269 G/A cg01420254 chr6:26195488 NA 0.75 6.21 0.32 1.58e-9 Iron status biomarkers (total iron binding capacity); CRC cis rs896854 0.875 rs4735333 chr8:95955074 G/A cg16049864 chr8:95962084 TP53INP1 -0.66 -12.06 -0.55 5.45e-28 Type 2 diabetes; CRC cis rs9926296 0.605 rs12448860 chr16:89849629 T/A cg03388025 chr16:89894329 SPIRE2 0.42 8.47 0.42 8.41e-16 Vitiligo; CRC trans rs11026407 0.967 rs7127246 chr11:22060228 C/G cg00789793 chr3:141329863 RASA2 -0.59 -6.19 -0.32 1.81e-9 Plasma thyroid-stimulating hormone levels; CRC cis rs2976388 0.967 rs2976395 chr8:143763750 G/A cg24046110 chr8:143859143 LYNX1 -0.37 -6.37 -0.33 6.29e-10 Urinary tract infection frequency; CRC cis rs4975709 0.610 rs1531994 chr5:1859297 T/C cg12288994 chr5:1860383 NA 0.39 6.73 0.35 7.66e-11 Cardiovascular disease risk factors; CRC cis rs798554 0.679 rs1636253 chr7:2885123 A/G cg04166393 chr7:2884313 GNA12 0.53 7.25 0.37 3.02e-12 Height; CRC trans rs10504229 1.000 rs74546828 chr8:58171678 A/G cg04077850 chr5:125800366 GRAMD3 0.37 6.27 0.33 1.15e-9 Developmental language disorder (linguistic errors); CRC cis rs9399135 0.935 rs9376086 chr6:135371329 T/C cg22676075 chr6:135203613 NA 0.39 6.08 0.32 3.42e-9 Red blood cell count; CRC cis rs875971 1.000 rs2420820 chr7:66091907 T/C cg18912574 chr7:65842487 NCRNA00174 -0.35 -5.83 -0.31 1.31e-8 Aortic root size; CRC cis rs1552244 0.832 rs67145301 chr3:10197314 G/A cg16606324 chr3:10149918 C3orf24 0.64 7.23 0.37 3.31e-12 Alzheimer's disease; CRC trans rs7671189 0.522 rs2087769 chr4:11740548 A/G cg18054620 chr5:111191530 C5orf13 -0.3 -6.03 -0.32 4.32e-9 Obesity-related traits; CRC cis rs4642101 0.512 rs12629892 chr3:12818920 A/G cg24848339 chr3:12840334 CAND2 0.33 6.13 0.32 2.54e-9 QRS complex (12-leadsum); CRC cis rs7809950 0.817 rs4727678 chr7:107083635 C/G cg23024343 chr7:107201750 COG5 -0.73 -10.08 -0.49 5.37e-21 Coronary artery disease; CRC cis rs243505 0.898 rs243541 chr7:148403243 A/T cg09806900 chr7:148480153 CUL1 -0.42 -5.83 -0.31 1.32e-8 Inflammatory bowel disease;Crohn's disease; CRC cis rs1267303 0.675 rs1267313 chr1:46986322 G/T cg08533674 chr1:46993347 NA 0.63 8.13 0.41 8.62e-15 Monobrow; CRC cis rs9467603 1.000 rs6940698 chr6:25821580 A/G cg12315302 chr6:26189340 HIST1H4D -0.73 -5.64 -0.3 3.69e-8 Intelligence (multi-trait analysis); CRC cis rs910316 1.000 rs12589376 chr14:75561152 C/T cg03030879 chr14:75389066 RPS6KL1 -0.46 -7.25 -0.37 2.99e-12 Height; CRC cis rs7208859 0.673 rs9915139 chr17:29158515 A/G cg13385521 chr17:29058706 SUZ12P 0.65 7.94 0.4 3.26e-14 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs853679 0.599 rs149990 chr6:27998258 G/A cg03623178 chr6:28175578 NA 0.84 7.95 0.4 2.95e-14 Depression; CRC cis rs12477438 0.748 rs4851185 chr2:99666497 G/A cg14399236 chr2:99771627 LIPT1;TSGA10 -0.6 -8.19 -0.41 6.03e-15 Chronic sinus infection; CRC cis rs2296342 0.522 rs1536036 chr6:33632014 A/G cg14003231 chr6:33640908 ITPR3 0.4 6.82 0.35 4.25e-11 Schizophrenia; CRC cis rs7586879 0.765 rs10171663 chr2:25086431 T/C cg22495460 chr2:25135724 ADCY3 -0.77 -12.77 -0.58 1.33e-30 Body mass index; CRC cis rs66823261 0.778 rs2906332 chr8:194943 C/T cg27532244 chr8:182981 ZNF596;RPL23AP53 -0.56 -6.41 -0.33 5.04e-10 Breast cancer (estrogen-receptor negative);Breast cancer; CRC cis rs2885056 0.830 rs2018810 chr19:10669172 A/G cg06392426 chr19:10676186 KRI1 0.59 6.98 0.36 1.64e-11 Red cell distribution width; CRC cis rs1005277 0.540 rs2474598 chr10:38430296 C/T cg25517755 chr10:38738941 LOC399744 0.46 6.62 0.34 1.45e-10 Extrinsic epigenetic age acceleration; CRC cis rs3751196 0.901 rs56255894 chr12:104163425 G/A cg02344784 chr12:104178138 NT5DC3 0.7 7.02 0.36 1.29e-11 Sense of smell; CRC cis rs9467711 0.606 rs9393714 chr6:26373740 G/T cg16898833 chr6:26189333 HIST1H4D 0.75 6.55 0.34 2.27e-10 Autism spectrum disorder or schizophrenia; CRC cis rs4319547 0.695 rs10846746 chr12:122868696 C/T cg05707623 chr12:122985044 ZCCHC8 0.77 9.31 0.46 1.85e-18 Body mass index; CRC cis rs2243480 1.000 rs313798 chr7:65493031 A/G cg12463550 chr7:65579703 CRCP 0.71 6.46 0.34 3.88e-10 Diabetic kidney disease; CRC trans rs7824557 0.524 rs7835318 chr8:10953874 G/A cg08975724 chr8:8085496 FLJ10661 -0.43 -6.59 -0.34 1.74e-10 Retinal vascular caliber; CRC cis rs769267 0.895 rs2315279 chr19:19479936 C/A cg02546618 chr19:19431379 KIAA0892;SF4 -0.45 -6.21 -0.32 1.61e-9 Tonsillectomy; CRC cis rs2839186 0.609 rs2839189 chr21:47694357 C/T cg02776659 chr21:47717406 C21orf57 0.36 5.77 0.3 1.81e-8 Testicular germ cell tumor; CRC cis rs2836974 0.897 rs13339986 chr21:40605982 T/C cg06238570 chr21:40685208 BRWD1 0.76 10.27 0.49 1.23e-21 Cognitive function; CRC cis rs17253792 0.545 rs12886406 chr14:56027605 G/A cg01858014 chr14:56050164 KTN1 -0.86 -6.64 -0.34 1.28e-10 Putamen volume; CRC cis rs6904897 0.538 rs4639353 chr6:135224328 A/G cg22676075 chr6:135203613 NA -0.77 -13.34 -0.59 9.31e-33 Mean corpuscular volume;Mean corpuscular hemoglobin; CRC cis rs853679 0.546 rs200950 chr6:27835772 A/G cg15845792 chr6:28175446 NA 0.73 6.16 0.32 2.08e-9 Depression; CRC cis rs6818397 1.000 rs6818397 chr4:3434885 A/C cg08741688 chr4:3415352 RGS12 0.38 6.18 0.32 1.88e-9 LDL cholesterol levels;Total cholesterol levels; CRC cis rs1153858 1.000 rs66528868 chr15:45668547 A/C cg10760299 chr15:45669010 GATM 0.49 7.65 0.39 2.19e-13 Homoarginine levels; CRC cis rs9549367 0.789 rs2287250 chr13:113889474 C/T cg00898013 chr13:113819073 PROZ 0.42 6.26 0.33 1.21e-9 Platelet distribution width; CRC cis rs7927771 0.524 rs10838784 chr11:47882341 G/A cg20307385 chr11:47447363 PSMC3 0.45 6.51 0.34 2.75e-10 Subjective well-being; CRC cis rs7044106 0.762 rs1547267 chr9:123408736 T/C cg09586646 chr9:123605570 PSMD5;LOC253039 0.63 8.86 0.44 5.1e-17 Hip circumference adjusted for BMI; CRC cis rs7945705 0.776 rs11042069 chr11:8817315 G/A cg14711859 chr11:8959438 ASCL3 -0.37 -5.85 -0.31 1.21e-8 Hemoglobin concentration; CRC cis rs9906695 0.950 rs67586205 chr17:32551087 G/A cg12698626 chr17:32581466 CCL2 0.41 5.7 0.3 2.72e-8 Monocyte percentage of white cells; CRC cis rs7786808 0.615 rs4909212 chr7:158197037 G/T cg09998033 chr7:158218633 PTPRN2 -0.57 -7.84 -0.4 6.21e-14 Obesity-related traits; CRC cis rs6912958 0.781 rs3918467 chr6:88180388 C/G cg08069147 chr6:88032118 GJB7;C6orf162 -0.53 -8.01 -0.4 2.07e-14 Monocyte percentage of white cells; CRC trans rs2553218 0.690 rs8032415 chr15:54851945 A/G cg23597370 chr4:26862044 STIM2 0.45 6.2 0.32 1.67e-9 Immune response to smallpox vaccine (IL-6); CRC cis rs7618915 0.547 rs11177 chr3:52721305 G/A cg05573699 chr3:52720067 GNL3;PBRM1 -0.45 -6.31 -0.33 9.1e-10 Bipolar disorder; CRC cis rs748404 0.631 rs6493083 chr15:43637985 A/G cg15269541 chr15:43626905 ADAL -0.39 -6.0 -0.31 5.18e-9 Lung cancer; CRC cis rs7107174 0.892 rs2510038 chr11:77966034 C/T cg02023728 chr11:77925099 USP35 0.54 7.59 0.39 3.41e-13 Testicular germ cell tumor; CRC cis rs9814567 0.806 rs4955534 chr3:134319723 T/A cg06109529 chr3:134205091 CEP63;ANAPC13 -0.68 -10.11 -0.49 4.15e-21 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC trans rs208520 0.690 rs1885100 chr6:66871047 C/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.05 -14.8 -0.63 2.42e-38 Exhaled nitric oxide output; CRC cis rs9303280 0.806 rs10852935 chr17:38031674 C/T cg00129232 chr17:37814104 STARD3 -0.48 -7.62 -0.39 2.8e-13 Self-reported allergy; CRC cis rs12477438 0.798 rs17708218 chr2:99696284 C/A cg14399236 chr2:99771627 LIPT1;TSGA10 -0.74 -10.34 -0.5 7.18e-22 Chronic sinus infection; CRC cis rs3741404 0.560 rs12362602 chr11:63908660 G/A cg20160996 chr11:63990575 FERMT3 0.4 6.48 0.34 3.27e-10 Platelet count; CRC cis rs4803468 0.967 rs3213860 chr19:41920211 T/C cg09537434 chr19:41945824 ATP5SL -0.97 -18.81 -0.72 4.3e-54 Height; CRC cis rs1552244 0.608 rs6764807 chr3:9998803 T/C cg08888203 chr3:10149979 C3orf24 0.46 7.21 0.37 3.9e-12 Alzheimer's disease; CRC cis rs11209185 0.527 rs11209186 chr1:68434340 A/G cg22082780 chr1:68452167 NA -0.38 -5.77 -0.3 1.85e-8 Itch intensity from mosquito bite adjusted by bite size; CRC cis rs9837602 1.000 rs13064704 chr3:99767541 G/A cg07805332 chr3:99536008 MIR548G;C3orf26 -0.48 -6.33 -0.33 8.13e-10 Breast cancer; CRC cis rs7769051 0.711 rs7770081 chr6:133089569 G/T cg22852734 chr6:133119734 C6orf192 0.9 10.79 0.51 1.99e-23 Type 2 diabetes nephropathy; CRC cis rs9393692 0.620 rs9366650 chr6:26335997 G/A cg00631329 chr6:26305371 NA -0.56 -9.48 -0.46 5.3e-19 Educational attainment; CRC cis rs2346160 0.867 rs2989556 chr6:167704404 T/A cg27333441 chr6:167680455 NA -0.4 -6.58 -0.34 1.83e-10 Parental extreme longevity (95 years and older); CRC cis rs12142240 0.698 rs12385695 chr1:46819021 A/G cg14993813 chr1:46806288 NSUN4 -0.48 -6.15 -0.32 2.24e-9 Menopause (age at onset); CRC cis rs2976388 0.578 rs34956412 chr8:143822028 C/T cg24046110 chr8:143859143 LYNX1 -0.42 -6.45 -0.33 4.08e-10 Urinary tract infection frequency; CRC cis rs9914988 0.832 rs9903248 chr17:27127439 G/T cg12682573 chr17:27188876 MIR451;MIR144 0.58 7.99 0.4 2.37e-14 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs7927771 0.524 rs7129797 chr11:47667167 G/C cg20307385 chr11:47447363 PSMC3 0.46 6.65 0.34 1.25e-10 Subjective well-being; CRC cis rs9527 0.545 rs7100369 chr10:104956218 C/A cg15744005 chr10:104629667 AS3MT -0.29 -5.76 -0.3 1.92e-8 Arsenic metabolism; CRC cis rs501120 0.929 rs605425 chr10:44750669 T/C cg09554077 chr10:44749378 NA 0.89 13.17 0.59 4.18e-32 Coronary artery disease;Coronary heart disease; CRC cis rs1862618 0.853 rs2113078 chr5:56087190 C/T cg24531977 chr5:56204891 C5orf35 -0.84 -11.4 -0.53 1.39e-25 Initial pursuit acceleration; CRC cis rs10504229 1.000 rs116995796 chr8:58181960 G/A cg02725872 chr8:58115012 NA -0.38 -6.45 -0.34 3.92e-10 Developmental language disorder (linguistic errors); CRC cis rs798502 0.541 rs2644307 chr7:2832973 G/A cg09658497 chr7:2847517 GNA12 -0.4 -6.36 -0.33 6.56e-10 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Inflammatory bowel disease;Waist circumference adjusted for BMI in non-smokers;Ulcerative colitis;Waist circumference adjusted for body mass index;Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction); CRC cis rs709400 0.628 rs11622356 chr14:103912195 C/T cg12935359 chr14:103987150 CKB -0.5 -7.67 -0.39 2.01e-13 Body mass index; CRC cis rs769267 0.930 rs3752151 chr19:19616026 T/C cg02546618 chr19:19431379 KIAA0892;SF4 0.43 5.86 0.31 1.1e-8 Tonsillectomy; CRC cis rs6694672 0.850 rs4915316 chr1:197059928 A/G cg13682187 chr1:196946512 CFHR5 0.43 7.0 0.36 1.41e-11 Asthma; CRC trans rs8035957 1.000 rs4924273 chr15:38846738 C/G cg07564175 chr17:8024546 HES7 -0.55 -6.42 -0.33 4.7e-10 Type 1 diabetes; CRC cis rs6504622 0.537 rs1052504 chr17:44993828 C/T cg16759221 chr17:45003025 GOSR2 -0.65 -10.49 -0.5 2.07e-22 Orofacial clefts; CRC cis rs8180040 1.000 rs2159400 chr3:47375890 T/C cg27129171 chr3:47204927 SETD2 -0.66 -10.52 -0.5 1.69e-22 Colorectal cancer; CRC cis rs7086803 1.000 rs7916159 chr10:114500377 A/G cg03281572 chr10:114502318 VTI1A 0.75 6.34 0.33 7.77e-10 Lung cancer; CRC trans rs928391 0.948 rs2735657 chr1:156780306 A/C cg14948448 chr4:148401661 EDNRA -0.49 -6.02 -0.31 4.69e-9 Platelet count; CRC cis rs7945705 0.747 rs11042150 chr11:9010819 T/C cg12365402 chr11:9010492 NRIP3 -0.57 -10.74 -0.51 2.88e-23 Hemoglobin concentration; CRC cis rs5769707 0.967 rs763127 chr22:50006078 C/T cg05373962 chr22:49881684 NA -0.4 -7.54 -0.38 4.65e-13 Monocyte count;Monocyte percentage of white cells; CRC cis rs10979 1.000 rs12211659 chr6:143898348 G/T cg25407410 chr6:143891975 LOC285740 -0.84 -13.84 -0.61 1.22e-34 Hypospadias; CRC cis rs10461617 0.541 rs860581 chr5:56150537 A/G cg24531977 chr5:56204891 C5orf35 -0.63 -6.54 -0.34 2.32e-10 Type 2 diabetes; CRC trans rs4971059 0.654 rs10157801 chr1:155120012 A/G cg16379337 chr7:115850450 TES 0.37 6.0 0.31 5.25e-9 Breast cancer; CRC cis rs1005277 0.579 rs2505198 chr10:38393183 A/C cg03665457 chr10:38645376 HSD17B7P2 -0.42 -6.03 -0.32 4.49e-9 Extrinsic epigenetic age acceleration; CRC cis rs2404602 0.647 rs35710279 chr15:77082234 T/A cg03037974 chr15:76606532 NA -0.51 -7.34 -0.38 1.64e-12 Blood metabolite levels; CRC cis rs931127 0.719 rs2127507 chr11:65454430 A/G cg27068330 chr11:65405492 SIPA1 -0.42 -5.87 -0.31 1.09e-8 Systemic lupus erythematosus; CRC cis rs7666738 0.830 rs28761309 chr4:98867393 C/T cg05340658 chr4:99064831 C4orf37 0.57 8.45 0.42 9.23e-16 Colonoscopy-negative controls vs population controls; CRC cis rs853679 0.517 rs9348796 chr6:28126202 A/G cg18032046 chr6:28092343 ZSCAN16 -0.51 -5.93 -0.31 7.47e-9 Depression; CRC cis rs2033711 0.840 rs10423138 chr19:58928302 T/C cg13877915 chr19:58951672 ZNF132 0.51 8.45 0.42 9.22e-16 Uric acid clearance; CRC trans rs6561151 0.957 rs3764147 chr13:44457925 C/T cg17145862 chr1:211918768 LPGAT1 -0.51 -7.31 -0.37 2.08e-12 Crohn's disease; CRC cis rs9486719 1.000 rs12193732 chr6:96942609 G/A cg18709589 chr6:96969512 KIAA0776 -0.51 -5.69 -0.3 2.79e-8 Migraine;Coronary artery disease; CRC cis rs1129187 0.719 rs3805953 chr6:42936900 C/T cg26304593 chr6:42947056 PEX6 -0.43 -6.05 -0.32 4.02e-9 Alzheimer's disease in APOE e4+ carriers; CRC cis rs9733 0.519 rs11807450 chr1:150677719 C/T cg10589385 chr1:150898437 SETDB1 0.31 6.68 0.35 1.04e-10 Tonsillectomy; CRC cis rs35264875 0.796 rs72930637 chr11:68869967 C/T cg01993067 chr11:68851601 TPCN2 0.55 6.09 0.32 3.1e-9 Blond vs. brown hair color; CRC cis rs950169 0.579 rs11633088 chr15:84672181 A/T cg17507749 chr15:85114479 UBE2QP1 -0.64 -8.79 -0.44 8.48e-17 Schizophrenia; CRC cis rs3087591 0.614 rs3785955 chr17:29647802 C/T cg24425628 chr17:29625626 OMG;NF1 0.71 13.15 0.59 4.98e-32 Hip circumference; CRC cis rs8141529 0.732 rs5762788 chr22:29174770 G/T cg15103426 chr22:29168792 CCDC117 0.58 8.64 0.43 2.4e-16 Lymphocyte counts; CRC cis rs6534441 0.857 rs6846869 chr4:125454820 G/A cg21609808 chr4:125404261 NA 0.4 5.92 0.31 8.09e-9 Major depressive disorder; CRC cis rs9491140 0.539 rs11154224 chr6:124678535 G/A cg19267163 chr6:125004984 NKAIN2 0.46 6.22 0.32 1.51e-9 Neuroticism; CRC cis rs10504229 0.683 rs11787247 chr8:58131528 G/T cg24829409 chr8:58192753 C8orf71 -0.55 -8.03 -0.4 1.71e-14 Developmental language disorder (linguistic errors); CRC trans rs11039798 0.844 rs6485820 chr11:48264711 A/G cg03929089 chr4:120376271 NA 0.66 6.31 0.33 9.22e-10 Axial length; CRC cis rs6964587 1.000 rs10264666 chr7:91578639 G/A cg17063962 chr7:91808500 NA -0.76 -12.36 -0.56 4.23e-29 Breast cancer; CRC cis rs7107174 1.000 rs10899478 chr11:78052238 C/T cg02023728 chr11:77925099 USP35 0.48 8.17 0.41 6.55e-15 Testicular germ cell tumor; CRC cis rs28655083 0.552 rs76055145 chr16:77124905 A/C cg01753188 chr16:77233325 SYCE1L;MON1B -0.58 -6.71 -0.35 8.75e-11 Lobe attachment (rater-scored or self-reported); CRC cis rs5753618 0.561 rs714909 chr22:31741067 G/A cg07713946 chr22:31675144 LIMK2 0.41 5.85 0.31 1.21e-8 Colorectal cancer; CRC cis rs6701037 0.681 rs34370567 chr1:175131340 C/T cg14847009 chr1:175162515 KIAA0040 -0.26 -5.69 -0.3 2.87e-8 Alcohol dependence; CRC cis rs9322193 0.884 rs11155669 chr6:149954637 T/C cg07701084 chr6:150067640 NUP43 0.55 8.04 0.41 1.58e-14 Lung cancer; CRC cis rs1185460 0.967 rs1786141 chr11:118938315 C/T cg23280166 chr11:118938394 VPS11 0.46 6.95 0.36 1.99e-11 Coronary artery disease; CRC cis rs7619833 0.512 rs12715119 chr3:27221769 T/C cg02860705 chr3:27208620 NA 0.39 6.06 0.32 3.79e-9 Breast cancer; CRC cis rs9926296 0.546 rs7187436 chr16:89845110 A/T cg21285383 chr16:89894308 SPIRE2 0.36 6.22 0.32 1.54e-9 Vitiligo; CRC cis rs7618915 0.547 rs62255371 chr3:52747321 A/G cg15147215 chr3:52552868 STAB1 -0.61 -10.07 -0.49 5.69e-21 Bipolar disorder; CRC cis rs4665809 0.590 rs5001914 chr2:26415429 A/G cg27170947 chr2:26402098 FAM59B -0.59 -7.65 -0.39 2.22e-13 Gut microbiome composition (summer); CRC cis rs5771242 0.776 rs6010198 chr22:50610628 A/G cg16473166 chr22:50639996 SELO -0.52 -6.27 -0.33 1.12e-9 Lung function (forced expiratory flow during mid-portion (25% and 75%) of forced vital capacity); CRC cis rs2625529 0.652 rs2034879 chr15:72429989 A/G cg16672083 chr15:72433130 SENP8 -0.47 -6.98 -0.36 1.61e-11 Red blood cell count; CRC cis rs34375054 0.573 rs12581813 chr12:125656402 A/G cg06287003 chr12:125626642 AACS -0.6 -6.86 -0.35 3.44e-11 Post bronchodilator FEV1/FVC ratio; CRC cis rs7618915 1.000 rs34569561 chr3:52287293 T/C cg18099408 chr3:52552593 STAB1 -0.38 -5.6 -0.3 4.5e-8 Bipolar disorder; CRC cis rs208520 0.731 rs12206488 chr6:66999917 G/T cg07460842 chr6:66804631 NA 0.95 11.04 0.52 2.52e-24 Exhaled nitric oxide output; CRC cis rs4803468 1.000 rs2304242 chr19:41944616 G/T cg09537434 chr19:41945824 ATP5SL 0.96 18.05 0.71 4.37e-51 Height; CRC cis rs2286885 0.965 rs10819167 chr9:129241716 T/A cg15282417 chr9:129245246 FAM125B 0.45 8.23 0.41 4.33e-15 Intraocular pressure; CRC cis rs17401966 0.867 rs12403443 chr1:10423988 A/G cg19773385 chr1:10388646 KIF1B -0.57 -7.78 -0.39 9.14e-14 Hepatocellular carcinoma; CRC cis rs7493 1.000 rs2299264 chr7:95046708 C/T cg21856205 chr7:94953877 PON1 -0.49 -6.51 -0.34 2.88e-10 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs8180040 0.800 rs7632501 chr3:47268306 T/C cg02527881 chr3:46936655 PTH1R 0.35 5.98 0.31 5.85e-9 Colorectal cancer; CRC cis rs7586879 1.000 rs6736711 chr2:25116456 C/T cg04586622 chr2:25135609 ADCY3 -0.43 -7.19 -0.37 4.46e-12 Body mass index; CRC cis rs7618501 0.602 rs2013208 chr3:50129399 C/T cg24308560 chr3:49941425 MST1R 0.51 8.28 0.42 3.16e-15 Intelligence (multi-trait analysis); CRC cis rs9311474 0.607 rs28661185 chr3:52567188 G/T cg15147215 chr3:52552868 STAB1 -0.67 -11.85 -0.55 3.22e-27 Electroencephalogram traits; CRC cis rs738322 0.577 rs6001034 chr22:38558459 A/G cg03162506 chr22:38580953 NA 0.27 5.82 0.31 1.4e-8 Cutaneous nevi; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg09730836 chr5:111496633 NCRNA00219;SNORA13 0.42 6.18 0.32 1.84e-9 Intelligence (multi-trait analysis); CRC cis rs11971779 0.616 rs2883772 chr7:139072756 T/C cg23387468 chr7:139079360 LUC7L2 0.41 7.04 0.36 1.14e-11 Diisocyanate-induced asthma; CRC cis rs4478858 0.775 rs6701861 chr1:31708125 A/C cg18939081 chr1:31884902 SERINC2 0.34 5.6 0.3 4.43e-8 Alcohol dependence; CRC cis rs12230513 0.732 rs7966770 chr12:55844717 T/C cg19537932 chr12:55886519 OR6C68 -0.73 -9.52 -0.46 3.94e-19 Contrast sensitivity; CRC cis rs4713118 0.540 rs469227 chr6:27970705 A/C cg03623178 chr6:28175578 NA 0.83 12.47 0.57 1.76e-29 Parkinson's disease; CRC cis rs11214589 0.905 rs12804573 chr11:113241726 G/A cg14159747 chr11:113255604 NA 0.6 11.82 0.55 4.17e-27 Neuroticism; CRC cis rs7666738 0.830 rs6532715 chr4:99016792 G/A cg17366294 chr4:99064904 C4orf37 0.43 7.28 0.37 2.52e-12 Colonoscopy-negative controls vs population controls; CRC cis rs7591163 1.000 rs2056566 chr2:228713241 G/A cg14646075 chr2:228736089 WDR69 -0.45 -6.14 -0.32 2.43e-9 Blood pressure; CRC cis rs2404602 0.735 rs62028423 chr15:76754514 G/A cg03037974 chr15:76606532 NA -0.53 -7.89 -0.4 4.63e-14 Blood metabolite levels; CRC cis rs9303401 0.614 rs3087762 chr17:56568680 C/T cg02118635 chr17:56770003 RAD51C;TEX14 0.77 9.58 0.47 2.52e-19 Cognitive test performance; CRC cis rs3736594 0.918 rs9677663 chr2:27972445 G/A cg27432699 chr2:27873401 GPN1 -0.63 -8.72 -0.43 1.39e-16 Fasting blood glucose;Fasting blood glucose (BMI interaction); CRC cis rs7786808 0.536 rs4909210 chr7:158194376 T/C cg17401720 chr7:158221031 PTPRN2 0.37 5.98 0.31 5.85e-9 Obesity-related traits; CRC trans rs9583531 0.657 rs7337126 chr13:111376788 A/G cg20064139 chr20:41823021 NA -0.29 -5.96 -0.31 6.35e-9 Coronary artery disease; CRC cis rs9409565 1.000 rs9409565 chr9:97251034 C/T cg04523069 chr9:97136363 HIATL1 0.37 5.76 0.3 1.95e-8 Colorectal cancer (alcohol consumption interaction); CRC cis rs6570726 0.935 rs392014 chr6:145843691 A/C cg05347473 chr6:146136440 FBXO30 0.37 5.88 0.31 1.02e-8 Lobe attachment (rater-scored or self-reported); CRC cis rs2576037 0.526 rs658756 chr18:44431832 A/G cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.62 -10.07 -0.49 5.79e-21 Personality dimensions; CRC cis rs4282054 0.631 rs13081155 chr3:52732429 A/G cg07507251 chr3:52567010 NT5DC2 0.45 6.8 0.35 4.98e-11 Cognitive function; CRC cis rs1158570 0.500 rs2554369 chr8:131314047 C/T cg26053073 chr8:131455383 NA -0.41 -6.36 -0.33 6.67e-10 Platelet count; CRC cis rs832540 0.656 rs832573 chr5:56159578 T/C cg12311346 chr5:56204834 C5orf35 -0.51 -7.31 -0.37 2.04e-12 Coronary artery disease; CRC cis rs1008375 0.933 rs6847966 chr4:17634255 G/A cg16339924 chr4:17578868 LAP3 0.54 7.05 0.36 1.03e-11 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs4820539 1.000 rs5751589 chr22:23475762 A/G cg14186256 chr22:23484241 RTDR1 -0.95 -19.03 -0.72 5.67e-55 Bone mineral density; CRC trans rs11088226 0.645 rs2833917 chr21:33957544 C/T cg09050820 chr6:167586206 TCP10L2 0.87 8.94 0.44 2.81e-17 Gastritis; CRC cis rs17270561 0.636 rs3922681 chr6:25698481 C/T cg16482183 chr6:26056742 HIST1H1C 0.72 8.75 0.43 1.11e-16 Iron status biomarkers; CRC cis rs1552244 0.554 rs6443275 chr3:10008819 G/A cg02579736 chr3:10068473 FANCD2;CIDECP 0.64 9.08 0.45 1.05e-17 Alzheimer's disease; CRC cis rs4588572 0.615 rs4143070 chr5:77769094 G/C cg11547950 chr5:77652471 NA -0.52 -7.74 -0.39 1.26e-13 Triglycerides; CRC trans rs561341 1.000 rs4795669 chr17:30244701 C/T cg20587970 chr11:113659929 NA -1.31 -18.09 -0.71 2.95e-51 Hip circumference adjusted for BMI; CRC cis rs10504229 0.689 rs17801390 chr8:58054768 T/C cg20607798 chr8:58055168 NA 0.55 6.19 0.32 1.82e-9 Developmental language disorder (linguistic errors); CRC cis rs992157 0.560 rs7605980 chr2:219100869 C/G cg04880052 chr2:219191631 PNKD 0.38 6.04 0.32 4.26e-9 Colorectal cancer; CRC cis rs4478858 0.709 rs3766296 chr1:31820223 G/A cg00250761 chr1:31883323 NA -0.44 -8.5 -0.42 6.71e-16 Alcohol dependence; CRC trans rs2243480 1.000 rs73142166 chr7:65375832 A/G cg10756647 chr7:56101905 PSPH 0.71 7.4 0.38 1.12e-12 Diabetic kidney disease; CRC cis rs6502050 0.871 rs7226049 chr17:80071049 A/G cg13198984 chr17:80129470 CCDC57 -0.47 -8.16 -0.41 7.39e-15 Life satisfaction; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg04785418 chr12:42538813 GXYLT1 0.46 6.14 0.32 2.4e-9 Anxiety disorder; CRC cis rs2249625 0.545 rs60835713 chr6:72880349 T/C cg18830697 chr6:72922368 RIMS1 0.41 8.01 0.4 2.02e-14 Acute urticaria and angioedema (non-steroidal anti-inflammatory drug-induced); CRC cis rs798554 0.660 rs2283783 chr7:2855326 G/A cg13628971 chr7:2884303 GNA12 0.43 6.42 0.33 4.87e-10 Height; CRC cis rs1799949 0.930 rs4584865 chr17:41424919 C/G cg19454999 chr17:41278357 BRCA1;NBR2 0.52 8.03 0.4 1.74e-14 Menopause (age at onset); CRC cis rs4862750 0.914 rs6553028 chr4:187876046 T/C cg11301795 chr4:187892539 NA -0.84 -18.08 -0.71 3.12e-51 Lobe attachment (rater-scored or self-reported); CRC cis rs911555 0.755 rs12436729 chr14:103929889 G/C cg12935359 chr14:103987150 CKB 0.56 8.94 0.44 2.96e-17 Intelligence (multi-trait analysis); CRC cis rs7208859 0.673 rs11649765 chr17:29233888 T/A cg01831904 chr17:28903510 LRRC37B2 -0.56 -5.83 -0.31 1.35e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs629535 0.814 rs604254 chr8:70059164 A/G cg26132723 chr8:70041827 NA 0.36 5.92 0.31 8.06e-9 Dupuytren's disease; CRC cis rs7107770 1.000 rs12791760 chr11:125091568 C/T cg27629782 chr11:125073726 PKNOX2 -0.46 -5.73 -0.3 2.23e-8 Photic sneeze reflex; CRC cis rs7666738 0.830 rs11097600 chr4:98959564 T/G cg17366294 chr4:99064904 C4orf37 0.43 7.22 0.37 3.66e-12 Colonoscopy-negative controls vs population controls; CRC cis rs9894429 0.671 rs6565616 chr17:79612161 C/T cg21028142 chr17:79581711 NPLOC4 0.34 7.18 0.37 4.69e-12 Eye color traits; CRC cis rs4481887 0.927 rs7555310 chr1:248487638 A/G cg13385794 chr1:248469461 NA 0.4 7.1 0.36 7.96e-12 Common traits (Other); CRC cis rs3204270 0.639 rs11871678 chr17:79654285 G/A cg18367735 chr17:79674897 NA 0.54 6.11 0.32 2.82e-9 Dental caries; CRC cis rs4481887 0.893 rs10888337 chr1:248428227 A/G cg13385794 chr1:248469461 NA -0.38 -6.82 -0.35 4.5e-11 Common traits (Other); CRC cis rs17155006 0.746 rs429252 chr7:107745554 T/C cg05962710 chr7:107745446 LAMB4 -0.41 -7.33 -0.37 1.85e-12 Pneumococcal bacteremia; CRC trans rs11039798 0.588 rs7108164 chr11:48626363 A/C cg15704280 chr7:45808275 SEPT13 0.65 6.93 0.36 2.21e-11 Axial length; CRC cis rs826838 0.935 rs980571 chr12:39127532 C/G cg13010199 chr12:38710504 ALG10B -0.42 -5.85 -0.31 1.16e-8 Heart rate; CRC cis rs9660992 0.573 rs1318187 chr1:205206172 T/A cg03948781 chr1:205179583 DSTYK 0.41 5.6 0.3 4.5e-8 Mean corpuscular volume;Mean platelet volume; CRC cis rs2836950 0.501 rs4818019 chr21:40694456 T/A cg11890956 chr21:40555474 PSMG1 -0.61 -8.88 -0.44 4.4e-17 Menarche (age at onset); CRC cis rs10463316 0.894 rs3846711 chr5:150740749 A/G cg03212797 chr5:150827313 SLC36A1 -0.5 -7.61 -0.39 2.95e-13 Metabolite levels (Pyroglutamine); CRC cis rs1046896 0.594 rs8070403 chr17:80865404 A/G cg02711726 chr17:80685570 FN3KRP -0.51 -6.84 -0.35 3.85e-11 Glycated hemoglobin levels; CRC cis rs6066835 0.867 rs73144586 chr20:47360454 G/A cg18078177 chr20:47281410 PREX1 0.61 5.6 0.3 4.46e-8 Multiple myeloma; CRC cis rs62064224 0.593 rs916663 chr17:30835833 A/C cg18200150 chr17:30822561 MYO1D -0.6 -11.37 -0.53 1.75e-25 Schizophrenia; CRC cis rs7301826 0.651 rs10773825 chr12:131298913 G/A cg11011512 chr12:131303247 STX2 0.37 5.61 0.3 4.35e-8 Plasma plasminogen activator levels; CRC cis rs477895 0.653 rs11602181 chr11:63896591 C/G cg04317338 chr11:64019027 PLCB3 0.6 7.49 0.38 6.21e-13 Mean platelet volume; CRC cis rs2404602 0.735 rs2454454 chr15:76823647 A/G cg03037974 chr15:76606532 NA -0.45 -6.93 -0.36 2.3e-11 Blood metabolite levels; CRC cis rs6460942 0.591 rs62451465 chr7:12364585 A/G cg20607287 chr7:12443886 VWDE -0.54 -6.1 -0.32 2.93e-9 Coronary artery disease; CRC cis rs59918340 0.728 rs2304279 chr8:142229891 A/G cg03316587 chr8:142245164 NA -0.37 -5.64 -0.3 3.63e-8 Immature fraction of reticulocytes; CRC cis rs4689592 0.503 rs66885632 chr4:7053738 T/C cg26116260 chr4:7069785 GRPEL1 -0.83 -9.76 -0.47 6.19e-20 Monocyte percentage of white cells; CRC cis rs7927771 1.000 rs11039426 chr11:47863119 G/A cg05585544 chr11:47624801 NA -0.61 -10.85 -0.51 1.22e-23 Subjective well-being; CRC cis rs3996993 0.809 rs4715353 chr6:52703766 A/G cg20803780 chr6:52668592 GSTA1 -0.35 -6.45 -0.33 4.1e-10 Hemoglobin concentration; CRC cis rs6951245 0.786 rs77943789 chr7:1140158 C/T cg24642844 chr7:1081250 C7orf50 -0.68 -8.45 -0.42 9.5e-16 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs908922 0.885 rs2181173 chr1:152474866 A/T cg23254163 chr1:152506842 NA -0.43 -8.07 -0.41 1.29e-14 Hair morphology; CRC cis rs720844 0.748 rs4972375 chr2:149324132 A/C cg09247360 chr2:149335327 NA 0.58 6.54 0.34 2.32e-10 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs274567 0.501 rs581968 chr5:131710202 G/A cg20512303 chr5:131592959 PDLIM4 -0.39 -6.65 -0.34 1.25e-10 Blood metabolite levels; CRC cis rs1799949 0.965 rs11651623 chr17:41329847 G/A cg05368731 chr17:41323189 NBR1 0.65 9.54 0.47 3.3e-19 Menopause (age at onset); CRC cis rs9291683 0.526 rs12506122 chr4:10033538 C/A cg00071950 chr4:10020882 SLC2A9 0.62 11.03 0.52 2.84e-24 Bone mineral density; CRC cis rs1552244 0.882 rs55808392 chr3:10054681 C/T cg02579736 chr3:10068473 FANCD2;CIDECP 0.97 12.42 0.57 2.56e-29 Alzheimer's disease; CRC cis rs9549260 0.755 rs2755216 chr13:41156938 G/A cg21288729 chr13:41239152 FOXO1 0.38 5.79 0.3 1.69e-8 Red blood cell count; CRC trans rs61931739 0.534 rs1586410 chr12:33999142 C/T cg26384229 chr12:38710491 ALG10B 0.52 6.53 0.34 2.52e-10 Morning vs. evening chronotype; CRC cis rs1005277 0.505 rs200937 chr10:38135772 T/C cg25427524 chr10:38739819 LOC399744 -0.73 -12.86 -0.58 6.04e-31 Extrinsic epigenetic age acceleration; CRC cis rs4700695 0.719 rs27079 chr5:65443966 C/T cg21114390 chr5:65439923 SFRS12 -0.65 -8.62 -0.43 2.79e-16 Facial morphology (factor 19); CRC cis rs921968 0.541 rs578450 chr2:219401237 C/T cg02176678 chr2:219576539 TTLL4 0.54 8.69 0.43 1.78e-16 Mean corpuscular hemoglobin concentration; CRC cis rs2842992 0.789 rs4235925 chr6:160202860 C/T cg19482086 chr6:160211437 TCP1;MRPL18 0.72 9.35 0.46 1.44e-18 Age-related macular degeneration (geographic atrophy); CRC cis rs6076065 0.723 rs6083110 chr20:23373674 C/T cg11657817 chr20:23433608 CST11 0.45 6.68 0.35 1.01e-10 Facial morphology (factor 15, philtrum width); CRC cis rs911119 0.866 rs2405393 chr20:23569392 G/C cg16589663 chr20:23618590 CST3 0.42 5.93 0.31 7.51e-9 Chronic kidney disease; CRC cis rs9858542 0.537 rs9863142 chr3:49366741 C/G cg00383909 chr3:49044727 WDR6 0.62 6.79 0.35 5.26e-11 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs10504229 0.683 rs35840293 chr8:58117634 C/T cg02725872 chr8:58115012 NA -0.64 -11.55 -0.54 3.85e-26 Developmental language disorder (linguistic errors); CRC cis rs40363 0.723 rs757269 chr16:3538003 A/G cg05754148 chr16:3507555 NAT15 -0.72 -7.33 -0.37 1.8e-12 Tuberculosis; CRC cis rs11785693 0.909 rs62489558 chr8:4968620 G/A cg26367366 chr8:4980734 NA 0.83 9.9 0.48 2.2e-20 Neuroticism (multi-trait analysis);Neuroticism; CRC cis rs5769765 0.908 rs9616376 chr22:50310829 A/G cg04121214 chr22:50244548 NA 0.42 5.9 0.31 9.05e-9 Schizophrenia; CRC trans rs11098499 0.954 rs2892848 chr4:120381341 C/T cg25214090 chr10:38739885 LOC399744 0.66 10.6 0.5 9.04e-23 Corneal astigmatism; CRC cis rs936229 0.768 rs11072509 chr15:75114374 C/G cg10253484 chr15:75165896 SCAMP2 -0.4 -5.84 -0.31 1.23e-8 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); CRC cis rs12612619 0.732 rs11126857 chr2:27297757 G/A cg00617064 chr2:27272375 NA 0.42 7.02 0.36 1.27e-11 Venous thromboembolism adjusted for sickle cell variant rs77121243-T; CRC cis rs12612619 0.732 rs11680096 chr2:27273571 T/C cg00617064 chr2:27272375 NA -0.38 -6.32 -0.33 8.35e-10 Venous thromboembolism adjusted for sickle cell variant rs77121243-T; CRC cis rs1580019 0.961 rs11768506 chr7:32494788 A/C cg07520158 chr7:32535189 LSM5;AVL9 0.45 6.48 0.34 3.4e-10 Cognitive ability; CRC cis rs17270561 0.609 rs9356985 chr6:25728098 C/T cg16482183 chr6:26056742 HIST1H1C 0.83 10.59 0.5 9.49e-23 Iron status biomarkers; CRC cis rs736408 0.609 rs2230535 chr3:52800284 T/C cg07507251 chr3:52567010 NT5DC2 0.41 5.87 0.31 1.06e-8 Bipolar disorder; CRC trans rs9329221 0.657 rs17694485 chr8:10114458 A/T cg06636001 chr8:8085503 FLJ10661 0.59 8.53 0.43 5.45e-16 Neuroticism; CRC cis rs2742417 1.000 rs2742421 chr3:45732515 G/T cg04837898 chr3:45731254 SACM1L 0.34 5.66 0.3 3.37e-8 Response to anti-depressant treatment in major depressive disorder; CRC cis rs4073582 0.894 rs801733 chr11:65934549 A/C cg16950941 chr11:66035639 RAB1B 0.66 9.53 0.46 3.68e-19 Gout; CRC cis rs4664308 0.692 rs4233681 chr2:160960058 T/C cg03641300 chr2:160917029 PLA2R1 -0.58 -9.18 -0.45 4.87e-18 Idiopathic membranous nephropathy; CRC cis rs12142240 0.698 rs67941619 chr1:46838219 A/G cg14993813 chr1:46806288 NSUN4 -0.48 -6.05 -0.32 3.98e-9 Menopause (age at onset); CRC cis rs6598955 0.724 rs12754536 chr1:26639605 T/C cg00852783 chr1:26633632 UBXN11 0.41 6.56 0.34 2.1e-10 Obesity-related traits; CRC cis rs1065656 0.553 rs344360 chr16:1839221 T/C cg00046913 chr16:1877150 HAGH;FAHD1 0.52 5.75 0.3 2.04e-8 Insulin-like growth factors; CRC trans rs561341 1.000 rs576985 chr17:30323323 C/T cg27661571 chr11:113659931 NA -0.95 -10.99 -0.52 3.76e-24 Hip circumference adjusted for BMI; CRC cis rs9916302 0.861 rs11658219 chr17:37709782 G/A cg00129232 chr17:37814104 STARD3 -0.56 -8.22 -0.41 4.78e-15 Glomerular filtration rate (creatinine); CRC trans rs453301 0.624 rs330049 chr8:9087299 C/T cg08975724 chr8:8085496 FLJ10661 0.45 6.83 0.35 4.04e-11 Joint mobility (Beighton score); CRC cis rs10256972 0.567 rs2949185 chr7:1209013 A/G cg22907277 chr7:1156413 C7orf50 0.65 9.87 0.48 2.72e-20 Longevity;Endometriosis; CRC cis rs7613875 0.620 rs17657688 chr3:50033228 C/T cg24308560 chr3:49941425 MST1R 0.43 6.8 0.35 5.06e-11 Body mass index; CRC trans rs11098499 0.754 rs28652763 chr4:120242312 C/T cg25214090 chr10:38739885 LOC399744 0.53 8.36 0.42 1.78e-15 Corneal astigmatism; CRC cis rs7589728 0.844 rs77144652 chr2:88496684 G/A cg07952391 chr2:88470173 THNSL2 0.62 5.95 0.31 7.01e-9 Plasma clusterin levels; CRC cis rs17767392 0.958 rs2214836 chr14:72025078 G/T cg13720639 chr14:72061746 SIPA1L1 0.56 6.88 0.35 3.04e-11 Mitral valve prolapse; CRC cis rs897984 0.683 rs13337900 chr16:30822409 G/A cg00531865 chr16:30841666 NA -0.5 -7.48 -0.38 6.61e-13 Dementia with Lewy bodies; CRC cis rs62064224 0.791 rs2344977 chr17:30720573 C/G cg25809561 chr17:30822961 MYO1D 0.71 12.42 0.56 2.74e-29 Schizophrenia; CRC trans rs800082 0.516 rs4511940 chr3:144219392 T/C cg24215973 chr2:240111563 HDAC4 0.47 6.46 0.34 3.87e-10 Smoking behavior; CRC cis rs10870270 0.956 rs4131689 chr10:133744328 A/C cg08754478 chr10:133766260 PPP2R2D 0.68 9.94 0.48 1.52e-20 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; CRC cis rs4665809 1.000 rs6546727 chr2:26275282 C/T cg22920501 chr2:26401640 FAM59B -0.52 -7.11 -0.36 7.25e-12 Gut microbiome composition (summer); CRC cis rs892961 0.899 rs72896163 chr17:75412525 C/T cg05865280 chr17:75406074 SEPT9 0.63 14.51 0.62 3.27e-37 Airflow obstruction; CRC cis rs7618915 0.501 rs3733041 chr3:52731598 T/C cg18099408 chr3:52552593 STAB1 -0.46 -7.66 -0.39 2.06e-13 Bipolar disorder; CRC cis rs11122272 0.735 rs2790881 chr1:231534181 A/G cg06096015 chr1:231504339 EGLN1 0.4 6.0 0.31 5.13e-9 Hemoglobin concentration; CRC cis rs2286885 0.965 rs10760440 chr9:129250831 C/T cg15282417 chr9:129245246 FAM125B 0.47 8.78 0.44 9.18e-17 Intraocular pressure; CRC cis rs1865760 0.713 rs2013063 chr6:25994098 C/T cg16482183 chr6:26056742 HIST1H1C 0.51 7.48 0.38 6.71e-13 Height; CRC cis rs2836974 0.605 rs2836988 chr21:40707975 A/G cg17971929 chr21:40555470 PSMG1 -0.66 -9.62 -0.47 1.89e-19 Cognitive function; CRC cis rs938554 0.513 rs3775948 chr4:9995182 G/C cg11266682 chr4:10021025 SLC2A9 0.36 6.29 0.33 9.99e-10 Blood metabolite levels; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg07489123 chr19:1812466 ATP8B3 0.38 6.02 0.31 4.62e-9 Liver disease severity in Alagille syndrome; CRC trans rs10983614 1.000 rs7867776 chr9:120072627 A/G cg17714010 chr17:78968450 CHMP6 0.49 6.76 0.35 6.33e-11 Survival in pancreatic cancer; CRC cis rs7666738 0.830 rs13101352 chr4:98957544 C/T cg05340658 chr4:99064831 C4orf37 0.61 9.54 0.47 3.37e-19 Colonoscopy-negative controls vs population controls; CRC cis rs1005277 0.563 rs2505216 chr10:38482830 T/C cg00409905 chr10:38381863 ZNF37A -0.65 -10.65 -0.51 5.95e-23 Extrinsic epigenetic age acceleration; CRC cis rs34375054 0.752 rs12582808 chr12:125661459 G/T cg02766259 chr12:125626809 AACS -0.48 -7.36 -0.38 1.47e-12 Post bronchodilator FEV1/FVC ratio; CRC cis rs1448094 0.512 rs6539926 chr12:86244460 G/A cg25456477 chr12:86230367 RASSF9 0.32 5.67 0.3 3.13e-8 Major depressive disorder; CRC cis rs13428823 0.928 rs3795955 chr2:25375105 T/C cg22495460 chr2:25135724 ADCY3 -0.4 -5.67 -0.3 3.08e-8 Height; CRC cis rs1799949 0.501 rs9675035 chr17:41415016 A/T cg01879757 chr17:41196368 BRCA1 -0.44 -6.68 -0.35 1.04e-10 Menopause (age at onset); CRC cis rs2985684 0.948 rs6572592 chr14:50080871 G/A cg23565292 chr14:50234668 KLHDC2 -0.42 -5.82 -0.31 1.4e-8 Carotid intima media thickness; CRC cis rs3736485 0.934 rs28393906 chr15:51867605 T/A cg08986416 chr15:51914746 DMXL2 -0.46 -6.64 -0.34 1.33e-10 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs870825 0.616 rs2696037 chr4:185610940 C/T cg04058563 chr4:185651563 MLF1IP -0.62 -6.88 -0.35 2.97e-11 Blood protein levels; CRC cis rs73206853 0.841 rs17792048 chr12:110866543 C/A cg12870014 chr12:110450643 ANKRD13A 0.81 8.39 0.42 1.42e-15 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC cis rs12701220 0.655 rs6955290 chr7:1151066 A/G cg26769984 chr7:1090371 C7orf50 -0.51 -7.25 -0.37 2.91e-12 Bronchopulmonary dysplasia; CRC cis rs11098499 0.955 rs1397608 chr4:120161744 A/G cg24375607 chr4:120327624 NA 0.43 6.69 0.35 9.56e-11 Corneal astigmatism; CRC trans rs60843830 1.000 rs55753056 chr2:243929 G/A cg11347411 chr7:150020925 ACTR3C;LRRC61 0.58 9.08 0.45 1.06e-17 Spherical equivalent (joint analysis main effects and education interaction); CRC cis rs2213920 0.516 rs34302658 chr9:118168158 T/A cg13918206 chr9:118159781 DEC1 -0.81 -7.66 -0.39 2.03e-13 Docetaxel-induced peripheral neuropathy in metastatic castrate-resistant prostate cancer; CRC cis rs12762955 0.507 rs10737004 chr10:1039019 T/C cg26597838 chr10:835615 NA -0.45 -6.08 -0.32 3.29e-9 Response to angiotensin II receptor blocker therapy; CRC cis rs7619833 0.620 rs1445111 chr3:27253971 C/T cg02860705 chr3:27208620 NA 0.38 6.02 0.32 4.53e-9 Breast cancer; CRC cis rs9733 0.596 rs17606613 chr1:150683015 C/T cg15448220 chr1:150897856 SETDB1 0.45 6.41 0.33 5.09e-10 Tonsillectomy; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg11094939 chr2:65454430 ACTR2 0.45 6.25 0.33 1.25e-9 Response to antipsychotic treatment; CRC cis rs8044868 0.586 rs7200854 chr16:72083318 G/A cg23815491 chr16:72088622 HP 0.5 7.23 0.37 3.35e-12 Body mass index (change over time) in cancer or chronic obstructive pulmonary disease;Body mass index (change over time) in cancer; CRC cis rs6912958 0.559 rs173333 chr6:88047754 T/G cg04972856 chr6:88032051 C6orf162;GJB7 0.31 5.92 0.31 8.09e-9 Monocyte percentage of white cells; CRC cis rs7615952 0.576 rs1127717 chr3:125826059 T/C cg06494592 chr3:125709126 NA -0.52 -6.29 -0.33 1e-9 Blood pressure (smoking interaction); CRC cis rs7980687 0.678 rs7132277 chr12:123593382 C/T cg00376283 chr12:123451042 ABCB9 -0.58 -6.75 -0.35 6.54e-11 Height;Educational attainment;Head circumference (infant); CRC cis rs9326248 0.727 rs4938347 chr11:117021759 T/A cg11861562 chr11:117069780 TAGLN 0.34 6.29 0.33 1.02e-9 Blood protein levels; CRC cis rs921968 0.565 rs586194 chr2:219610433 A/G cg02176678 chr2:219576539 TTLL4 -0.44 -6.96 -0.36 1.9e-11 Mean corpuscular hemoglobin concentration; CRC cis rs7647973 1.000 rs1982861 chr3:49577665 A/G cg07690219 chr3:49449608 TCTA;RHOA -0.55 -6.22 -0.32 1.5e-9 Menarche (age at onset); CRC cis rs801193 0.967 rs2707841 chr7:66157020 A/G cg18876405 chr7:65276391 NA 0.61 10.75 0.51 2.7e-23 Aortic root size; CRC cis rs4332037 0.802 rs73048106 chr7:1929019 G/T cg25834613 chr7:1915315 MAD1L1 -0.47 -6.78 -0.35 5.73e-11 Bipolar disorder; CRC cis rs853679 0.760 rs9468317 chr6:28198456 A/G cg15786705 chr6:28176104 NA 0.62 6.98 0.36 1.67e-11 Depression; CRC cis rs798554 0.797 rs798493 chr7:2798731 A/G cg17321639 chr7:2759063 NA -0.53 -6.96 -0.36 1.85e-11 Height; CRC cis rs6502050 0.835 rs7501527 chr17:80099355 A/C cg02741985 chr17:80059408 CCDC57 0.44 7.26 0.37 2.75e-12 Life satisfaction; CRC cis rs6968419 0.755 rs6948556 chr7:115895433 T/C cg02561103 chr7:115862891 TES -0.43 -6.47 -0.34 3.48e-10 Intraocular pressure; CRC cis rs2764208 0.576 rs6457791 chr6:34759954 A/G cg07306190 chr6:34760872 UHRF1BP1 -0.35 -6.23 -0.33 1.4e-9 Systemic lupus erythematosus; CRC cis rs10504229 0.815 rs55855654 chr8:58164299 T/G cg02290350 chr8:58132656 NA -0.5 -6.19 -0.32 1.75e-9 Developmental language disorder (linguistic errors); CRC cis rs992157 0.866 rs2292554 chr2:219146868 T/C cg04880052 chr2:219191631 PNKD -0.44 -6.94 -0.36 2.15e-11 Colorectal cancer; CRC cis rs9487051 0.676 rs9400267 chr6:109600164 T/C cg12927641 chr6:109611667 NA -0.36 -6.32 -0.33 8.39e-10 Reticulocyte fraction of red cells; CRC cis rs908922 0.676 rs539393 chr1:152518896 C/T cg23254163 chr1:152506842 NA 0.45 8.87 0.44 4.86e-17 Hair morphology; CRC cis rs2072499 0.932 rs3001790 chr1:156165290 T/G cg25208724 chr1:156163844 SLC25A44 1.11 26.71 0.83 2.13e-84 Testicular germ cell tumor; CRC cis rs1949733 0.523 rs55977448 chr4:8542918 G/T cg11789530 chr4:8429930 ACOX3 -0.58 -7.8 -0.4 8.07e-14 Response to antineoplastic agents; CRC cis rs501120 0.584 rs1680636 chr10:44675941 G/A cg09554077 chr10:44749378 NA 0.7 7.85 0.4 5.95e-14 Coronary artery disease;Coronary heart disease; CRC cis rs7493 0.950 rs56265549 chr7:95047155 G/A cg19678392 chr7:94953810 PON1 -0.56 -7.06 -0.36 9.89e-12 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs2576037 0.542 rs4630643 chr18:44508142 G/A cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.59 -8.58 -0.43 3.75e-16 Personality dimensions; CRC cis rs3741151 0.686 rs7112924 chr11:73106408 C/T cg17517138 chr11:73019481 ARHGEF17 0.56 5.94 0.31 7.36e-9 GIP levels in response to oral glucose tolerance test (120 minutes); CRC cis rs2439831 0.850 rs56909447 chr15:44137618 G/A cg15269541 chr15:43626905 ADAL -0.49 -5.9 -0.31 9.27e-9 Lung cancer in ever smokers; CRC cis rs977987 0.843 rs10871312 chr16:75486202 C/T cg03315344 chr16:75512273 CHST6 0.57 9.72 0.47 8.76e-20 Dupuytren's disease; CRC trans rs60843830 0.964 rs17713568 chr2:242132 G/A cg11347411 chr7:150020925 ACTR3C;LRRC61 0.61 9.5 0.46 4.46e-19 Spherical equivalent (joint analysis main effects and education interaction); CRC cis rs875971 1.000 rs697970 chr7:65560052 G/C cg18912574 chr7:65842487 NCRNA00174 -0.37 -6.36 -0.33 6.71e-10 Aortic root size; CRC cis rs9303280 0.870 rs6503524 chr17:38069809 C/T cg11212589 chr17:38028394 ZPBP2 -0.44 -8.02 -0.4 1.89e-14 Self-reported allergy; CRC cis rs10876993 0.821 rs1678522 chr12:58049923 G/A cg18357645 chr12:58087776 OS9 0.57 7.75 0.39 1.17e-13 Celiac disease or Rheumatoid arthritis; CRC cis rs9372498 0.536 rs9489436 chr6:118873817 A/C cg15382696 chr6:118971807 C6orf204 0.61 7.88 0.4 4.86e-14 Diastolic blood pressure; CRC cis rs11112613 0.595 rs871219 chr12:105938519 C/A cg03607813 chr12:105948248 NA 0.75 9.14 0.45 6.82e-18 Corrected insulin response;Corrected insulin response adjusted for insulin sensitivity index; CRC trans rs11581859 0.950 rs7524165 chr1:99388780 T/C cg12183875 chr3:169587454 LRRC31 0.28 6.33 0.33 7.89e-10 Response to cognitive-behavioural therapy in anxiety disorder; CRC cis rs11098499 0.909 rs28555550 chr4:120211040 C/G cg09307838 chr4:120376055 NA 0.65 9.99 0.48 1.08e-20 Corneal astigmatism; CRC cis rs4665809 0.590 rs13019536 chr2:26526978 C/A cg26119090 chr2:26468346 HADHA;HADHB -0.64 -8.18 -0.41 6.32e-15 Gut microbiome composition (summer); CRC cis rs3008870 0.917 rs12044492 chr1:67461667 T/C cg08660285 chr1:67390436 MIER1;WDR78 -1.04 -15.24 -0.64 4.66e-40 Lymphocyte percentage of white cells; CRC cis rs10479542 0.752 rs12658664 chr5:178986987 C/T cg00080972 chr5:178986291 RUFY1 0.48 9.33 0.46 1.63e-18 Lung cancer; CRC cis rs561341 1.000 rs550923 chr17:30327013 G/C cg23018236 chr17:30244563 NA -0.67 -8.03 -0.4 1.78e-14 Hip circumference adjusted for BMI; CRC cis rs13108904 0.870 rs11721789 chr4:1254414 C/A cg00684032 chr4:1343700 KIAA1530 0.46 6.88 0.35 3.02e-11 Obesity-related traits; CRC cis rs10504229 1.000 rs76944716 chr8:58191643 T/C cg05313129 chr8:58192883 C8orf71 -0.45 -6.56 -0.34 2.08e-10 Developmental language disorder (linguistic errors); CRC cis rs6460942 0.591 rs4721080 chr7:12337785 T/C cg20607287 chr7:12443886 VWDE -0.55 -6.18 -0.32 1.92e-9 Coronary artery disease; CRC cis rs1018836 0.798 rs28568272 chr8:91652958 A/G cg16814680 chr8:91681699 NA -0.87 -14.9 -0.63 9.57e-39 Ejection fraction in Tripanosoma cruzi seropositivity; CRC cis rs1395 0.710 rs11674947 chr2:27471996 A/G cg23587288 chr2:27483067 SLC30A3 -0.37 -6.31 -0.33 9.04e-10 Blood metabolite levels; CRC cis rs2842992 0.724 rs9365097 chr6:160211259 G/A cg16489826 chr6:160211363 TCP1;MRPL18 0.59 8.83 0.44 6.27e-17 Age-related macular degeneration (geographic atrophy); CRC cis rs2625529 0.824 rs2415121 chr15:72134018 C/T cg16672083 chr15:72433130 SENP8 -0.44 -6.55 -0.34 2.28e-10 Red blood cell count; CRC cis rs1005277 0.565 rs2474565 chr10:38380828 A/G cg17219203 chr10:38645113 HSD17B7P2 -0.42 -5.84 -0.31 1.28e-8 Extrinsic epigenetic age acceleration; CRC cis rs3740540 0.530 rs10751598 chr10:126290951 A/G cg04949429 chr10:126290192 LHPP -0.42 -6.27 -0.33 1.13e-9 Obesity-related traits;Acute lymphoblastic leukemia (childhood); CRC cis rs10540 1.000 rs12417570 chr11:462684 C/T cg15790184 chr11:494944 RNH1 0.63 5.99 0.31 5.37e-9 Body mass index; CRC cis rs9322193 0.923 rs2297928 chr6:150039720 G/C cg05861140 chr6:150128134 PCMT1 -0.36 -5.85 -0.31 1.18e-8 Lung cancer; CRC cis rs11711311 1.000 rs9879760 chr3:113457948 G/A cg15478005 chr3:113465772 ATP6V1A;NAA50 0.45 6.31 0.33 8.92e-10 IgG glycosylation; CRC cis rs9311474 0.508 rs11720243 chr3:52618018 T/C cg15147215 chr3:52552868 STAB1 -0.64 -11.19 -0.52 7.72e-25 Electroencephalogram traits; CRC cis rs9372498 0.505 rs62424202 chr6:118851027 T/C cg22561889 chr6:118971681 C6orf204 0.47 6.06 0.32 3.78e-9 Diastolic blood pressure; CRC trans rs12200782 0.578 rs9467739 chr6:26382573 A/T cg25800765 chr12:85673347 ALX1 0.26 5.96 0.31 6.54e-9 Small cell lung carcinoma; CRC cis rs7618915 0.547 rs35211965 chr3:52685305 C/G cg11645453 chr3:52864694 ITIH4 0.37 6.41 0.33 4.91e-10 Bipolar disorder; CRC cis rs67311347 1.000 rs9817142 chr3:40425774 C/A cg09455208 chr3:40491958 NA 0.48 9.22 0.45 3.54e-18 Renal cell carcinoma; CRC trans rs10982213 0.830 rs2274163 chr9:117188714 C/T cg05377417 chr17:59940892 BRIP1 -0.44 -6.94 -0.36 2.09e-11 Interleukin-6 levels; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg14274482 chr22:50913571 SBF1 0.42 6.07 0.32 3.5e-9 Response to antipsychotic treatment; CRC cis rs6598955 0.671 rs6658935 chr1:26568912 G/A cg04990556 chr1:26633338 UBXN11 0.56 6.02 0.32 4.53e-9 Obesity-related traits; CRC cis rs7943203 0.849 rs10789665 chr11:108356680 T/C cg14761454 chr11:108092087 ATM;NPAT 0.39 5.72 0.3 2.45e-8 Red blood cell count;Mean corpuscular volume; CRC trans rs7395662 0.927 rs2135690 chr11:48733601 A/G cg21153622 chr11:89784906 NA 0.44 7.12 0.37 6.64e-12 HDL cholesterol; CRC trans rs11039798 0.588 rs12284168 chr11:48555627 C/T cg03929089 chr4:120376271 NA 0.65 6.67 0.35 1.08e-10 Axial length; CRC cis rs4664293 0.867 rs16822558 chr2:160601007 A/G cg08347373 chr2:160653686 CD302 -0.47 -7.43 -0.38 9.32e-13 Monocyte percentage of white cells; CRC cis rs10493773 0.862 rs12075929 chr1:86248138 A/C cg17807903 chr1:86174739 ZNHIT6 0.51 10.26 0.49 1.26e-21 Urate levels in overweight individuals; CRC cis rs780096 0.525 rs13388159 chr2:27648284 A/T cg21248554 chr2:27665150 KRTCAP3 -0.32 -7.39 -0.38 1.22e-12 Total body bone mineral density; CRC cis rs2836974 0.897 rs2836927 chr21:40543216 T/C cg06238570 chr21:40685208 BRWD1 0.76 10.62 0.51 7.3e-23 Cognitive function; CRC cis rs10256972 0.567 rs7782651 chr7:1159895 T/G cg26608667 chr7:1196370 ZFAND2A 0.39 6.0 0.31 5.19e-9 Longevity;Endometriosis; CRC cis rs8180040 0.620 rs17784127 chr3:47061700 T/C cg27129171 chr3:47204927 SETD2 -0.73 -11.47 -0.53 7.42e-26 Colorectal cancer; CRC cis rs13191362 0.935 rs7769048 chr6:163010040 T/A cg06582575 chr6:163149167 PACRG;PARK2 0.75 10.24 0.49 1.58e-21 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs1799949 1.000 rs1799966 chr17:41223094 T/C cg23758822 chr17:41437982 NA 0.8 13.62 0.6 8.32e-34 Menopause (age at onset); CRC cis rs3733585 0.638 rs6449155 chr4:9956547 T/G cg11266682 chr4:10021025 SLC2A9 -0.47 -9.69 -0.47 1.05e-19 Cleft plate (environmental tobacco smoke interaction); CRC cis rs6594499 0.872 rs1379300 chr5:110441439 A/G cg04022379 chr5:110408740 TSLP 0.43 6.38 0.33 6e-10 Allergic disease (asthma, hay fever or eczema); CRC trans rs875971 0.660 rs2191268 chr7:66110224 C/T cg24881689 chr7:143825000 OR2A14 -0.43 -7.01 -0.36 1.32e-11 Aortic root size; CRC cis rs2836974 0.932 rs35571600 chr21:40590624 A/C cg11644478 chr21:40555479 PSMG1 0.82 12.46 0.57 1.86e-29 Cognitive function; CRC cis rs11123610 0.520 rs35482526 chr2:3720707 C/G cg00999904 chr2:3704751 ALLC -0.57 -6.77 -0.35 6e-11 Response to inhaled corticosteroid treatment in asthma (change in FEV1); CRC cis rs801193 1.000 rs2420824 chr7:66131116 G/A cg18876405 chr7:65276391 NA -0.62 -11.23 -0.53 5.33e-25 Aortic root size; CRC cis rs1129187 0.967 rs3805951 chr6:42937176 C/A cg05552183 chr6:42928497 GNMT 0.61 9.6 0.47 2.14e-19 Alzheimer's disease in APOE e4+ carriers; CRC cis rs6541297 1.000 rs2144298 chr1:230280198 T/C cg05784532 chr1:230284198 GALNT2 0.48 6.54 0.34 2.4e-10 Coronary artery disease; CRC cis rs9916302 0.706 rs8073907 chr17:37424149 C/T cg00129232 chr17:37814104 STARD3 -0.57 -7.05 -0.36 1.03e-11 Glomerular filtration rate (creatinine); CRC cis rs3820928 0.839 rs13404750 chr2:227876129 G/A cg11843606 chr2:227700838 RHBDD1 -0.39 -5.66 -0.3 3.31e-8 Pulmonary function; CRC cis rs11098499 0.909 rs28668716 chr4:120309875 T/C cg09307838 chr4:120376055 NA 0.71 10.91 0.52 7.11e-24 Corneal astigmatism; CRC cis rs3815700 1.000 rs8104726 chr19:33094675 G/A cg02997394 chr19:33096574 ANKRD27 0.73 8.27 0.41 3.46e-15 Eosinophilic esophagitis; CRC cis rs2066819 0.892 rs117305040 chr12:56657888 A/G cg26714650 chr12:56694279 CS -1.41 -11.64 -0.54 1.88e-26 Psoriasis vulgaris; CRC cis rs763014 0.966 rs4984903 chr16:680695 A/G cg08989290 chr16:615782 NHLRC4 0.47 9.07 0.45 1.11e-17 Height; CRC cis rs6879260 1.000 rs888922 chr5:179731635 C/G cg23248424 chr5:179741104 GFPT2 -0.65 -10.04 -0.48 7.15e-21 Height; CRC cis rs1577917 0.958 rs34994386 chr6:86524135 A/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.51 -6.85 -0.35 3.57e-11 Response to antipsychotic treatment; CRC cis rs7586879 0.639 rs6545776 chr2:25099357 A/C cg22495460 chr2:25135724 ADCY3 -0.87 -16.79 -0.68 4.07e-46 Body mass index; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg04193083 chr17:41323562 NBR1 0.43 6.55 0.34 2.2e-10 Liver disease severity in Alagille syndrome; CRC trans rs9326248 0.906 rs171052 chr11:117081763 C/G cg18755114 chr2:209119030 IDH1 0.42 6.34 0.33 7.67e-10 Blood protein levels; CRC cis rs9649213 0.555 rs6948346 chr7:97959956 A/G cg00277769 chr7:97922759 BAIAP2L1 -0.59 -10.01 -0.48 8.88e-21 Prostate cancer (SNP x SNP interaction); CRC cis rs4243830 0.850 rs4908911 chr1:6599523 C/T cg22792644 chr1:6614718 TAS1R1;NOL9 -0.69 -7.76 -0.39 1.08e-13 Body mass index; CRC cis rs9818758 0.607 rs73082362 chr3:49113729 C/T cg07636037 chr3:49044803 WDR6 -0.84 -6.02 -0.32 4.57e-9 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; CRC cis rs1816752 0.905 rs7991450 chr13:25000036 T/G cg02811702 chr13:24901961 NA 0.45 6.22 0.32 1.53e-9 Obesity-related traits; CRC cis rs6495367 1.000 rs6495367 chr15:79375347 C/T cg17916960 chr15:79447300 NA 0.36 5.7 0.3 2.65e-8 Spherical equivalent (joint analysis main effects and education interaction); CRC cis rs9916302 0.851 rs12936646 chr17:37647450 A/T cg15445000 chr17:37608096 MED1 0.4 8.69 0.43 1.71e-16 Glomerular filtration rate (creatinine); CRC trans rs45509595 0.841 rs9368531 chr6:27781872 G/C cg06606381 chr12:133084897 FBRSL1 -0.78 -6.64 -0.34 1.26e-10 Breast cancer; CRC cis rs12142240 0.698 rs17361950 chr1:46864150 C/T cg14993813 chr1:46806288 NSUN4 -0.52 -6.3 -0.33 9.32e-10 Menopause (age at onset); CRC cis rs72634258 0.699 rs12128234 chr1:8170219 T/C cg26816564 chr1:7831052 VAMP3 -0.54 -6.26 -0.33 1.19e-9 Inflammatory bowel disease; CRC cis rs9733 0.596 rs72702580 chr1:150691285 A/T cg10589385 chr1:150898437 SETDB1 0.28 5.96 0.31 6.66e-9 Tonsillectomy; CRC trans rs9858542 1.000 rs9823546 chr3:49705512 T/A cg21665057 chr3:196295764 WDR53;FBXO45 -0.66 -8.64 -0.43 2.53e-16 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs12701220 0.725 rs13242971 chr7:1055515 C/T cg26240231 chr7:1148101 C7orf50 -0.42 -5.61 -0.3 4.4e-8 Bronchopulmonary dysplasia; CRC cis rs1707322 0.721 rs6429574 chr1:46134054 A/G cg06784218 chr1:46089804 CCDC17 0.62 11.61 0.54 2.35e-26 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs13256369 0.865 rs13282523 chr8:8577293 C/G cg17143192 chr8:8559678 CLDN23 0.43 5.8 0.3 1.59e-8 Obesity-related traits; CRC cis rs9292777 0.966 rs1445001 chr5:40431664 A/G cg09067459 chr5:40385259 NA 0.51 8.92 0.44 3.39e-17 Crohn's disease;Multiple sclerosis; CRC cis rs616402 0.527 rs11121581 chr1:10577740 A/G cg17425144 chr1:10567563 PEX14 0.58 13.37 0.59 7.21e-33 Breast size; CRC cis rs7538876 0.903 rs6681150 chr1:17750685 G/A cg01904812 chr1:17746340 RCC2 0.36 5.9 0.31 9.12e-9 Basal cell carcinoma; CRC cis rs832540 0.618 rs41106 chr5:56145057 G/T cg12311346 chr5:56204834 C5orf35 -0.53 -7.85 -0.4 5.77e-14 Coronary artery disease; CRC cis rs7833790 0.685 rs13255262 chr8:82728024 T/G cg27398817 chr8:82754497 SNX16 -0.43 -5.88 -0.31 1.02e-8 Diastolic blood pressure; CRC cis rs2361718 0.500 rs8064429 chr17:78096187 A/C cg27427491 chr17:78079615 GAA -0.49 -7.09 -0.36 8.3e-12 Yeast infection; CRC trans rs7301826 0.627 rs7315707 chr12:131272819 A/G cg09019002 chr7:102715232 ARMC10;FBXL13 0.5 6.24 0.33 1.34e-9 Plasma plasminogen activator levels; CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg19540316 chr13:113622750 MCF2L -0.48 -6.29 -0.33 1e-9 Diisocyanate-induced asthma; CRC cis rs6504622 0.875 rs28553405 chr17:45045895 A/G cg16759221 chr17:45003025 GOSR2 -0.54 -8.56 -0.43 4.27e-16 Orofacial clefts; CRC cis rs9649213 0.593 rs34776142 chr7:97899873 C/T cg24562669 chr7:97807699 LMTK2 0.48 7.98 0.4 2.42e-14 Prostate cancer (SNP x SNP interaction); CRC cis rs9837602 0.529 rs1087198 chr3:99524381 C/T cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G -0.49 -6.48 -0.34 3.26e-10 Breast cancer; CRC cis rs10924970 0.967 rs7518225 chr1:235394541 A/C cg26050004 chr1:235667680 B3GALNT2 0.39 5.78 0.3 1.71e-8 Asthma; CRC cis rs6582630 0.555 rs11181684 chr12:38388000 T/C cg13010199 chr12:38710504 ALG10B 0.47 6.37 0.33 6.37e-10 Drug-induced liver injury (flucloxacillin); CRC cis rs28386778 0.897 rs2584640 chr17:61863488 C/T cg22520471 chr17:61851767 DDX42;CCDC47 0.75 11.73 0.54 8.92e-27 Prudent dietary pattern; CRC cis rs7954584 0.567 rs11043251 chr12:122373279 C/T cg21171335 chr12:122356390 WDR66 0.4 6.13 0.32 2.5e-9 Mean corpuscular volume; CRC cis rs10504229 1.000 rs17217082 chr8:58180918 G/A cg02725872 chr8:58115012 NA -0.38 -6.43 -0.33 4.44e-10 Developmental language disorder (linguistic errors); CRC cis rs6570726 0.791 rs12208812 chr6:145900924 T/G cg13319975 chr6:146136371 FBXO30 -0.42 -6.17 -0.32 1.98e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs9435341 0.965 rs3108680 chr1:107572997 T/C cg11070056 chr1:107600091 PRMT6 0.38 5.98 0.31 5.81e-9 Facial morphology (factor 21, depth of nasal alae); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg17004975 chr10:81743287 NA -0.34 -6.07 -0.32 3.48e-9 Liver disease severity in Alagille syndrome; CRC cis rs6500602 0.739 rs4786502 chr16:4537104 T/C cg14951292 chr16:4525986 HMOX2;NMRAL1 0.54 8.02 0.4 1.86e-14 Schizophrenia; CRC cis rs4664293 0.867 rs2357532 chr2:160597427 G/A cg08347373 chr2:160653686 CD302 -0.47 -7.47 -0.38 7.38e-13 Monocyte percentage of white cells; CRC cis rs2880765 0.566 rs17553790 chr15:86013665 C/T cg10818794 chr15:86012489 AKAP13 0.49 7.71 0.39 1.53e-13 Coronary artery disease; CRC cis rs116095464 0.558 rs1541822 chr5:269234 A/C cg22496380 chr5:211416 CCDC127 0.91 10.37 0.5 5.42e-22 Breast cancer; CRC cis rs11711311 0.955 rs3796254 chr3:113380332 T/C cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.52 -6.8 -0.35 5.02e-11 IgG glycosylation; CRC cis rs25645 0.830 rs3935281 chr17:38188419 C/T cg17344932 chr17:38183730 MED24;SNORD124 0.87 17.34 0.69 2.58e-48 Myeloid white cell count; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg27498675 chr19:41945691 ATP5SL 0.48 6.18 0.32 1.94e-9 Thyroid stimulating hormone; CRC cis rs66569888 0.789 rs66826026 chr2:106732879 C/T cg16099169 chr2:106886729 NA -0.54 -8.07 -0.41 1.37e-14 Facial morphology (factor 23); CRC cis rs3785574 0.962 rs2584623 chr17:61906679 G/A cg06873352 chr17:61820015 STRADA 0.49 7.77 0.39 1e-13 Height; CRC cis rs311392 0.554 rs369839 chr8:55097431 A/C cg06042504 chr8:55087323 NA -0.37 -5.77 -0.3 1.79e-8 Pelvic organ prolapse (moderate/severe); CRC cis rs6921919 0.525 rs1361386 chr6:28305604 G/A cg03623178 chr6:28175578 NA 0.45 6.0 0.31 5.12e-9 Autism spectrum disorder or schizophrenia; CRC cis rs11645898 0.810 rs72787060 chr16:72105371 T/C cg14768367 chr16:72042858 DHODH -0.71 -7.27 -0.37 2.58e-12 Blood protein levels; CRC cis rs1005277 0.505 rs13503 chr10:38239843 C/A cg00409905 chr10:38381863 ZNF37A 0.64 10.48 0.5 2.23e-22 Extrinsic epigenetic age acceleration; CRC cis rs10242455 0.702 rs17854665 chr7:99050039 G/A cg18809830 chr7:99032528 PTCD1 -1.03 -7.7 -0.39 1.61e-13 Blood metabolite levels; CRC cis rs113123495 0.609 rs2485278 chr19:5645204 A/G cg26242866 chr19:5711310 LONP1 0.7 5.81 0.31 1.47e-8 Obsessive-compulsive symptoms; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg04127825 chr1:167503222 NA 0.48 6.63 0.34 1.34e-10 Response to antipsychotic treatment; CRC trans rs2727020 0.701 rs7949044 chr11:49597334 C/T cg03929089 chr4:120376271 NA -0.84 -12.38 -0.56 3.56e-29 Coronary artery disease; CRC trans rs11343 0.675 rs7359333 chr16:19262344 A/T cg07878378 chr8:56987195 RPS20;SNORD54 -0.47 -6.08 -0.32 3.28e-9 Parkinson's disease; CRC cis rs8060686 0.920 rs73591961 chr16:67801309 G/A cg04539111 chr16:67997858 SLC12A4 -0.51 -5.91 -0.31 8.72e-9 HDL cholesterol;Metabolic syndrome; CRC cis rs67311347 1.000 rs9834052 chr3:40399060 G/A cg24209194 chr3:40518798 ZNF619 0.42 6.45 0.34 3.92e-10 Renal cell carcinoma; CRC cis rs654950 0.934 rs638859 chr1:42001444 A/G cg06885757 chr1:42089581 HIVEP3 0.38 6.3 0.33 9.4e-10 Airway imaging phenotypes; CRC cis rs2811415 0.597 rs13073261 chr3:127751493 A/G cg13719885 chr3:127795394 NA -0.37 -5.67 -0.3 3.19e-8 Lung function (FEV1/FVC); CRC cis rs78761021 0.867 rs8077150 chr17:9788769 C/T cg26853458 chr17:9805074 RCVRN 0.37 7.46 0.38 8.01e-13 Type 2 diabetes; CRC cis rs9463078 0.764 rs10948190 chr6:44942300 C/T cg25276700 chr6:44698697 NA -0.27 -6.7 -0.35 9.04e-11 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; CRC cis rs4970988 0.556 rs2280078 chr1:150600181 C/T cg18016565 chr1:150552671 MCL1 -0.51 -7.48 -0.38 6.68e-13 Urate levels; CRC cis rs6540559 0.546 rs735694 chr1:210034029 T/C cg22029157 chr1:209979665 IRF6 0.61 6.77 0.35 5.84e-11 Cleft lip with or without cleft palate; CRC cis rs9400271 0.632 rs9374069 chr6:109586334 A/G cg01475377 chr6:109611718 NA -0.35 -6.1 -0.32 3e-9 Sum neutrophil eosinophil counts;Sum basophil neutrophil counts;White blood cell count;Neutrophil count;Myeloid white cell count;Granulocyte count; CRC cis rs4819052 0.765 rs2838852 chr21:46677037 C/A cg02159808 chr21:46707872 POFUT2;LOC642852 0.53 6.82 0.35 4.28e-11 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC trans rs6544773 0.630 rs341602 chr2:45065503 A/G cg10208897 chr5:178548229 ADAMTS2 0.35 6.16 0.32 2.11e-9 Mosquito bite size; CRC cis rs801193 0.569 rs2707824 chr7:66189243 A/G cg18876405 chr7:65276391 NA 0.51 8.29 0.42 2.97e-15 Aortic root size; CRC cis rs7662987 0.517 rs2602880 chr4:100040653 C/T cg12011299 chr4:100065546 ADH4 0.49 9.26 0.45 2.63e-18 Smoking initiation; CRC cis rs2996428 0.667 rs72640928 chr1:3768568 T/C cg17848003 chr1:3704513 LRRC47 0.41 5.9 0.31 8.99e-9 Red cell distribution width; CRC trans rs2321882 0.834 rs17682567 chr13:59457467 T/C cg04268950 chr11:130298854 ADAMTS8 -0.45 -5.99 -0.31 5.64e-9 Body mass index; CRC cis rs881375 0.692 rs2072438 chr9:123651301 T/C cg09586646 chr9:123605570 PSMD5;LOC253039 0.46 6.91 0.36 2.56e-11 Rheumatoid arthritis; CRC cis rs904251 0.965 rs62406516 chr6:37439364 C/T cg01843034 chr6:37503916 NA -0.38 -6.94 -0.36 2.05e-11 Cognitive performance; CRC cis rs728616 0.614 rs1538818 chr10:82122793 G/A cg05935833 chr10:81318306 SFTPA2 -0.58 -7.02 -0.36 1.28e-11 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs875971 0.545 rs11766183 chr7:65839160 G/C cg18876405 chr7:65276391 NA 0.47 6.41 0.33 5.04e-10 Aortic root size; CRC trans rs11581859 0.950 rs72730307 chr1:99373916 A/T cg12183875 chr3:169587454 LRRC31 0.28 6.52 0.34 2.72e-10 Response to cognitive-behavioural therapy in anxiety disorder; CRC cis rs7772486 0.846 rs2892453 chr6:146377717 C/A cg23711669 chr6:146136114 FBXO30 0.62 10.67 0.51 5.03e-23 Lobe attachment (rater-scored or self-reported); CRC cis rs7512552 0.839 rs1627235 chr1:150358858 C/T cg15654264 chr1:150340011 RPRD2 0.6 8.44 0.42 1.02e-15 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); CRC cis rs17270561 0.609 rs9358885 chr6:25758024 T/C cg16482183 chr6:26056742 HIST1H1C 0.84 10.61 0.5 8.14e-23 Iron status biomarkers; CRC cis rs801193 0.967 rs2707849 chr7:66152712 T/C cg18876405 chr7:65276391 NA 0.61 10.69 0.51 4.37e-23 Aortic root size; CRC cis rs1801251 1.000 rs11679079 chr2:233612656 C/T cg25237894 chr2:233734115 C2orf82 0.54 8.8 0.44 7.77e-17 Coronary artery disease; CRC cis rs7552404 0.889 rs2211080 chr1:76243438 G/A cg10523679 chr1:76189770 ACADM 0.84 11.56 0.54 3.48e-26 Blood metabolite levels;Acylcarnitine levels; CRC cis rs10504229 0.683 rs67048677 chr8:58140023 C/G cg05313129 chr8:58192883 C8orf71 -0.43 -6.11 -0.32 2.74e-9 Developmental language disorder (linguistic errors); CRC cis rs1506636 1.000 rs659416 chr7:123401764 A/G cg03229431 chr7:123269106 ASB15 -0.71 -11.42 -0.53 1.16e-25 Plateletcrit;Platelet count; CRC cis rs644799 0.710 rs666398 chr11:95551136 C/T cg25622487 chr11:95524042 FAM76B;CEP57 0.8 13.52 0.6 2.03e-33 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs4555082 0.834 rs2735826 chr14:105710866 G/A cg13114125 chr14:105738426 BRF1 -0.8 -11.97 -0.55 1.22e-27 Mean platelet volume;Platelet distribution width; CRC cis rs2204008 0.744 rs11514358 chr12:38255526 G/A cg13010199 chr12:38710504 ALG10B 0.45 5.75 0.3 2.07e-8 Bladder cancer; CRC cis rs2688608 0.868 rs2688625 chr10:75631548 T/C cg00564723 chr10:75632066 CAMK2G -0.22 -5.66 -0.3 3.32e-8 Inflammatory bowel disease; CRC cis rs748404 0.631 rs28702649 chr15:43648629 C/T cg02155558 chr15:43621948 ADAL;LCMT2 0.52 7.37 0.38 1.43e-12 Lung cancer; CRC cis rs734999 0.505 rs4073286 chr1:2539901 A/C cg20673091 chr1:2541236 MMEL1 0.36 5.93 0.31 7.65e-9 Ulcerative colitis; CRC cis rs9916302 0.768 rs62077464 chr17:37656056 C/G cg07936489 chr17:37558343 FBXL20 -0.75 -10.88 -0.51 9.7e-24 Glomerular filtration rate (creatinine); CRC cis rs7917772 0.636 rs2249845 chr10:104512095 A/G cg04362960 chr10:104952993 NT5C2 0.46 6.09 0.32 3.16e-9 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC cis rs7726839 0.540 rs7558 chr5:660491 C/T cg14541582 chr5:601475 NA -0.33 -6.45 -0.34 3.91e-10 Obesity-related traits; CRC cis rs877282 0.891 rs11599917 chr10:762288 G/A cg17470449 chr10:769945 NA 0.65 8.49 0.42 7.13e-16 Uric acid levels; CRC cis rs1218582 0.772 rs6683557 chr1:154852307 C/G cg03351412 chr1:154909251 PMVK 0.54 8.69 0.43 1.76e-16 Prostate cancer; CRC trans rs1656966 1.000 rs1656966 chr3:186466252 C/T cg00699721 chr20:32950990 ITCH 0.39 6.04 0.32 4.25e-9 Myopia (pathological); CRC cis rs4819052 0.851 rs10470247 chr21:46659018 T/C cg19498844 chr21:46707878 POFUT2;LOC642852 0.75 10.82 0.51 1.49e-23 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs4713118 0.869 rs6901520 chr6:27714575 G/T cg15845792 chr6:28175446 NA 0.66 9.22 0.45 3.56e-18 Parkinson's disease; CRC cis rs6921919 0.789 rs6456814 chr6:28305812 C/A cg21251018 chr6:28226885 NKAPL 0.44 6.57 0.34 1.97e-10 Autism spectrum disorder or schizophrenia; CRC cis rs7044106 0.762 rs12003646 chr9:123470621 A/G cg09586646 chr9:123605570 PSMD5;LOC253039 0.62 8.71 0.43 1.51e-16 Hip circumference adjusted for BMI; CRC cis rs7647973 0.667 rs11721148 chr3:49646669 G/A cg13072238 chr3:49761600 GMPPB -0.51 -5.81 -0.3 1.5e-8 Menarche (age at onset); CRC cis rs4253772 0.591 rs12167567 chr22:46659942 G/C cg03482458 chr22:46692211 CN5H6.4;GTSE1 0.55 7.0 0.36 1.44e-11 LDL cholesterol;Cholesterol, total; CRC cis rs11214589 0.905 rs1078 chr11:113241877 C/T cg14159747 chr11:113255604 NA 0.59 11.73 0.54 8.53e-27 Neuroticism; CRC cis rs79387448 0.638 rs11465698 chr2:103054577 T/C cg00507830 chr2:103233733 NA 0.55 5.77 0.3 1.88e-8 Gut microbiota (bacterial taxa); CRC cis rs3806843 0.520 rs246051 chr5:140326464 G/A cg19875535 chr5:140030758 IK 0.39 6.02 0.31 4.67e-9 Depressive symptoms (multi-trait analysis); CRC trans rs3808502 0.526 rs36048422 chr8:11417144 T/C cg06636001 chr8:8085503 FLJ10661 -0.51 -7.68 -0.39 1.79e-13 Neuroticism; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg17930852 chr1:45957182 TESK2 0.42 6.33 0.33 7.95e-10 Intelligence (multi-trait analysis); CRC cis rs9368481 0.729 rs10946881 chr6:26914611 C/T cg18278486 chr6:26987575 LOC100270746;C6orf41 0.41 6.61 0.34 1.57e-10 Autism spectrum disorder or schizophrenia; CRC cis rs17384381 1.000 rs36110608 chr1:85852936 A/C cg16011679 chr1:85725395 C1orf52 0.63 6.45 0.33 4.05e-10 Lobe attachment (rater-scored or self-reported); CRC cis rs7223966 1.000 rs8080211 chr17:61729882 A/G cg23090583 chr17:61904693 PSMC5;FTSJ3 0.56 6.73 0.35 7.42e-11 Hip circumference adjusted for BMI;Body mass index; CRC cis rs8141797 0.502 rs12484381 chr22:24577121 G/C cg20894457 chr22:24584366 SUSD2 0.6 7.66 0.39 2.09e-13 Amyotrophic lateral sclerosis;Coronary artery disease; CRC cis rs4299518 0.516 rs12490293 chr3:45788127 T/C cg04837898 chr3:45731254 SACM1L 0.37 6.04 0.32 4.25e-9 Hirschsprung disease; CRC cis rs71403859 0.667 rs35538253 chr16:71677975 C/T cg08717414 chr16:71523259 ZNF19 -1.0 -9.01 -0.44 1.73e-17 Post bronchodilator FEV1; CRC cis rs6546324 0.592 rs2861648 chr2:67803908 C/T cg15745817 chr2:67799979 NA -0.53 -8.85 -0.44 5.36e-17 Endometriosis; CRC cis rs6570726 0.935 rs391524 chr6:145823844 A/G cg23711669 chr6:146136114 FBXO30 0.68 12.16 0.56 2.33e-28 Lobe attachment (rater-scored or self-reported); CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg23151374 chr4:164415611 C4orf43 -0.52 -6.31 -0.33 8.96e-10 Diisocyanate-induced asthma; CRC cis rs2976388 0.556 rs4736321 chr8:143822194 C/T cg15511327 chr8:143859410 LYNX1 -0.38 -6.0 -0.31 5.14e-9 Urinary tract infection frequency; CRC cis rs9372498 0.536 rs62422229 chr6:118959288 T/C cg22561889 chr6:118971681 C6orf204 0.52 6.58 0.34 1.85e-10 Diastolic blood pressure; CRC cis rs1008375 1.000 rs10939746 chr4:17684951 A/G cg04450456 chr4:17643702 FAM184B -0.39 -6.25 -0.33 1.27e-9 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs9322193 0.923 rs1934534 chr6:150033032 A/G cg07701084 chr6:150067640 NUP43 0.55 7.96 0.4 2.74e-14 Lung cancer; CRC cis rs3820068 0.603 rs59558854 chr1:15971399 T/G cg13390004 chr1:15929781 NA 0.53 7.41 0.38 1.07e-12 Systolic blood pressure; CRC cis rs11153730 0.503 rs283040 chr6:118631934 A/G cg15382696 chr6:118971807 C6orf204 -0.36 -5.71 -0.3 2.58e-8 QT interval;Heart rate;QRS duration;QRS complex (Sokolow-Lyon); CRC cis rs62229266 0.633 rs743420 chr21:37387402 A/G cg12218747 chr21:37451666 NA -0.34 -5.83 -0.31 1.31e-8 Mitral valve prolapse; CRC cis rs6963495 0.745 rs2392749 chr7:105182605 A/G cg19920283 chr7:105172520 RINT1 0.54 6.74 0.35 7.32e-11 Bipolar disorder (body mass index interaction); CRC cis rs17021463 0.807 rs6532480 chr4:95277038 T/C cg11021082 chr4:95130006 SMARCAD1 0.45 6.77 0.35 5.98e-11 Testicular germ cell tumor; CRC trans rs875971 0.660 rs2191268 chr7:66110224 C/T cg21354621 chr12:46384284 SFRS2IP -0.39 -6.02 -0.31 4.77e-9 Aortic root size; CRC cis rs863345 0.604 rs12041348 chr1:158482042 A/C cg12129480 chr1:158549410 OR10X1 -0.3 -6.29 -0.33 1.04e-9 Pneumococcal bacteremia; CRC cis rs7772486 0.712 rs6570726 chr6:146159460 T/C cg23711669 chr6:146136114 FBXO30 0.67 11.53 0.54 4.58e-26 Lobe attachment (rater-scored or self-reported); CRC cis rs713477 0.654 rs998871 chr14:55918302 G/A cg21836586 chr14:55907198 TBPL2 0.32 5.62 0.3 4.16e-8 Pediatric bone mineral content (femoral neck); CRC cis rs4332037 0.707 rs11763813 chr7:1896690 C/T cg02421172 chr7:1938701 MAD1L1 0.42 5.82 0.31 1.4e-8 Bipolar disorder; CRC cis rs868943 0.743 rs11153591 chr6:116328533 A/T cg18764771 chr6:116381957 FRK 0.28 6.69 0.35 9.75e-11 Total cholesterol levels; CRC cis rs526821 0.532 rs578067 chr11:55313690 T/G cg04317927 chr11:55418816 OR4S2 0.38 6.49 0.34 3.24e-10 Pediatric bone mineral density (spine); CRC cis rs853679 0.517 rs9393885 chr6:28050009 A/T cg25164649 chr6:28176230 NA 0.73 9.32 0.46 1.74e-18 Depression; CRC cis rs1129187 0.755 rs9471985 chr6:42941324 T/C cg03790207 chr6:42947109 PEX6 -0.52 -7.61 -0.39 2.84e-13 Alzheimer's disease in APOE e4+ carriers; CRC cis rs375066 0.623 rs1549953 chr19:44348768 T/C cg19542119 chr19:44331823 ZNF283 0.4 5.61 0.3 4.24e-8 Breast cancer; CRC cis rs28386778 0.933 rs2665804 chr17:61951836 G/T cg22520471 chr17:61851767 DDX42;CCDC47 0.71 11.0 0.52 3.55e-24 Prudent dietary pattern; CRC cis rs28386778 0.863 rs894414 chr17:61916384 T/C cg22520471 chr17:61851767 DDX42;CCDC47 0.75 11.71 0.54 1.02e-26 Prudent dietary pattern; CRC cis rs853679 0.760 rs9468317 chr6:28198456 A/G cg25164649 chr6:28176230 NA 0.52 5.72 0.3 2.41e-8 Depression; CRC cis rs473651 0.935 rs482775 chr2:239335403 G/C cg21699342 chr2:239360505 ASB1 0.56 10.13 0.49 3.68e-21 Multiple system atrophy; CRC cis rs7666738 0.830 rs13122456 chr4:98936011 A/G cg05340658 chr4:99064831 C4orf37 0.6 9.35 0.46 1.41e-18 Colonoscopy-negative controls vs population controls; CRC cis rs138880 0.542 rs9616215 chr22:50318834 C/T cg22709217 chr22:50311962 ALG12;CRELD2 -0.97 -8.87 -0.44 4.83e-17 Schizophrenia; CRC cis rs10504229 1.000 rs112284078 chr8:58191640 A/G cg24829409 chr8:58192753 C8orf71 -0.68 -10.89 -0.51 8.91e-24 Developmental language disorder (linguistic errors); CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg08180934 chr12:16035177 STRAP -0.42 -6.11 -0.32 2.76e-9 Myopia (pathological); CRC cis rs1552244 1.000 rs13319597 chr3:10126312 A/C cg08888203 chr3:10149979 C3orf24 -0.74 -10.55 -0.5 1.37e-22 Alzheimer's disease; CRC trans rs6951245 1.000 rs28379681 chr7:1070539 C/T cg13565492 chr6:43139072 SRF -0.71 -7.31 -0.37 2.04e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs5769765 0.773 rs9616382 chr22:50312979 C/T cg04121214 chr22:50244548 NA 0.42 5.89 0.31 9.4e-9 Schizophrenia; CRC cis rs12479064 0.724 rs737094 chr2:100089078 G/A cg14399236 chr2:99771627 LIPT1;TSGA10 -0.61 -7.22 -0.37 3.53e-12 Chronic sinus infection; CRC cis rs8177253 0.665 rs11921527 chr3:133441167 G/A cg17775713 chr3:133465469 TF 0.33 5.87 0.31 1.04e-8 Iron status biomarkers; CRC cis rs754466 0.580 rs11002289 chr10:79532580 G/A cg26805224 chr10:79626177 DLG5 -0.5 -7.38 -0.38 1.28e-12 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs11785400 0.793 rs34875149 chr8:143736131 G/A cg24634471 chr8:143751801 JRK 0.48 6.52 0.34 2.61e-10 Schizophrenia; CRC cis rs4731207 0.698 rs10270784 chr7:124446208 A/T cg23710748 chr7:124431027 NA 0.37 5.96 0.31 6.53e-9 Cutaneous malignant melanoma; CRC cis rs10489202 0.632 rs12410730 chr1:168069477 T/C cg24449463 chr1:168025552 DCAF6 -0.51 -7.46 -0.38 7.78e-13 Schizophrenia; CRC cis rs546131 0.928 rs558967 chr11:34827168 T/A cg24088639 chr11:34937564 PDHX;APIP -0.46 -6.44 -0.33 4.13e-10 Lung disease severity in cystic fibrosis; CRC cis rs4713118 0.629 rs149899 chr6:28019979 C/T cg15786705 chr6:28176104 NA 0.67 9.29 0.46 2.23e-18 Parkinson's disease; CRC cis rs2282802 0.585 rs2189659 chr5:139697220 C/A cg26211634 chr5:139558579 C5orf32 -0.45 -7.76 -0.39 1.05e-13 Intelligence (multi-trait analysis); CRC cis rs2841233 0.681 rs2582558 chr14:105347488 A/G cg03469805 chr14:105330648 KIAA0284 0.27 5.69 0.3 2.87e-8 IgG glycosylation; CRC cis rs1878931 0.597 rs37816 chr16:3456371 G/A cg26668626 chr16:3451006 ZNF174;ZNF434 -0.56 -6.85 -0.35 3.58e-11 Body mass index (adult); CRC cis rs11864453 0.826 rs6499559 chr16:72132064 G/C cg01557791 chr16:72042693 DHODH -0.47 -6.59 -0.34 1.76e-10 Fibrinogen levels; CRC cis rs8177253 1.000 rs8177262 chr3:133480652 A/G cg16262614 chr3:133464971 TF -0.33 -5.89 -0.31 9.35e-9 Iron status biomarkers; CRC cis rs155076 1.000 rs261431 chr13:21865738 A/G cg21970626 chr13:21893289 NA -0.42 -5.62 -0.3 4.06e-8 White matter hyperintensity burden; CRC trans rs7824557 0.564 rs12550129 chr8:11233917 C/T cg16141378 chr3:129829833 LOC729375 0.42 6.23 0.32 1.42e-9 Retinal vascular caliber; CRC cis rs11711311 1.000 rs2242109 chr3:113434100 G/T cg15478005 chr3:113465772 ATP6V1A;NAA50 0.45 6.13 0.32 2.49e-9 IgG glycosylation; CRC cis rs7923609 0.812 rs10822184 chr10:65337153 C/T cg08743896 chr10:65200160 JMJD1C 0.42 5.94 0.31 7.17e-9 Educational attainment;Liver enzyme levels (alkaline phosphatase); CRC trans rs7726839 0.574 rs12522955 chr5:639231 C/A cg25482853 chr8:67687455 SGK3 1.11 12.97 0.58 2.27e-31 Obesity-related traits; CRC cis rs9992667 0.910 rs4535339 chr4:38689228 A/G cg19726192 chr4:38663646 FLJ13197 -0.7 -8.76 -0.43 1.03e-16 Eosinophil percentage of granulocytes; CRC cis rs7552404 1.000 rs1498315 chr1:76159225 G/A cg22875332 chr1:76189707 ACADM 0.68 9.25 0.45 2.82e-18 Blood metabolite levels;Acylcarnitine levels; CRC cis rs4713118 0.513 rs156738 chr6:28014025 G/C cg21251018 chr6:28226885 NKAPL 0.48 7.4 0.38 1.14e-12 Parkinson's disease; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg16682046 chr11:82612617 PRCP;C11orf82 0.42 6.02 0.31 4.61e-9 Response to antipsychotic treatment; CRC cis rs3789045 0.866 rs61817482 chr1:204570347 G/A cg17419461 chr1:204415978 PIK3C2B -0.53 -7.57 -0.39 3.7e-13 Educational attainment (college completion); CRC trans rs4332037 0.539 rs11764780 chr7:2020904 G/C cg11693508 chr17:37793320 STARD3 0.65 7.74 0.39 1.24e-13 Bipolar disorder; CRC cis rs7762018 0.770 rs3823466 chr6:170189926 C/T cg24289452 chr6:170231220 NA -0.62 -7.47 -0.38 7.39e-13 Thiazide-induced adverse metabolic effects in hypertensive patients; CRC trans rs925098 0.577 rs2724470 chr4:17996046 A/G cg11753193 chr8:94753277 RBM12B -0.46 -6.82 -0.35 4.41e-11 Birth weight;Height; CRC cis rs7412746 0.658 rs7528773 chr1:150915875 G/A cg15448220 chr1:150897856 SETDB1 0.56 8.23 0.41 4.44e-15 Melanoma; CRC cis rs9640161 0.702 rs11765692 chr7:150026567 C/T cg12556325 chr7:150026731 C7orf29;LRRC61 -0.42 -6.45 -0.34 4.01e-10 Blood protein levels;Circulating chemerin levels; CRC cis rs9837602 1.000 rs35669453 chr3:99766063 G/A cg07805332 chr3:99536008 MIR548G;C3orf26 -0.48 -6.33 -0.33 8.13e-10 Breast cancer; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg12171159 chr11:72504902 STARD10 0.35 6.12 0.32 2.61e-9 Liver disease severity in Alagille syndrome; CRC cis rs6964587 0.692 rs2158138 chr7:91700879 A/G cg17063962 chr7:91808500 NA 0.6 9.56 0.47 2.77e-19 Breast cancer; CRC cis rs875971 0.540 rs4717275 chr7:65265180 C/T cg18912574 chr7:65842487 NCRNA00174 -0.34 -5.68 -0.3 2.99e-8 Aortic root size; CRC cis rs10504229 0.953 rs67886764 chr8:58187117 T/C cg02725872 chr8:58115012 NA -0.38 -6.43 -0.33 4.44e-10 Developmental language disorder (linguistic errors); CRC cis rs11122272 0.735 rs2486735 chr1:231521778 C/T cg06096015 chr1:231504339 EGLN1 0.4 5.98 0.31 5.78e-9 Hemoglobin concentration; CRC cis rs7727544 0.548 rs4705938 chr5:131694077 A/G cg04518342 chr5:131593106 PDLIM4 0.34 6.05 0.32 4.04e-9 Blood metabolite levels; CRC cis rs728616 0.614 rs61859209 chr10:82128309 G/A cg11900509 chr10:81946545 ANXA11 -0.56 -6.3 -0.33 9.41e-10 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs17666538 0.535 rs1669658 chr8:607380 A/G cg02524346 chr8:600233 NA 0.88 8.23 0.41 4.57e-15 IgG glycosylation; CRC trans rs16971802 1.000 rs16971802 chr17:34311387 A/G cg07584734 chr8:49235737 NA 0.65 6.18 0.32 1.92e-9 Blood protein levels; CRC cis rs1552244 0.808 rs17032306 chr3:10091399 C/G cg00166722 chr3:10149974 C3orf24 0.67 9.23 0.45 3.37e-18 Alzheimer's disease; CRC cis rs728616 0.867 rs17883671 chr10:81695193 C/T cg11900509 chr10:81946545 ANXA11 -0.65 -6.71 -0.35 8.77e-11 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs10504229 0.683 rs56192850 chr8:58135356 A/G cg21724239 chr8:58056113 NA 0.49 6.81 0.35 4.75e-11 Developmental language disorder (linguistic errors); CRC cis rs7677751 0.806 rs7679903 chr4:55097373 T/C cg00691999 chr4:55094011 PDGFRA 0.42 5.98 0.31 5.66e-9 Corneal astigmatism; CRC cis rs7635838 0.892 rs9870881 chr3:11447082 A/G cg00170343 chr3:11313890 ATG7 0.42 6.37 0.33 6.38e-10 HDL cholesterol; CRC cis rs7829975 0.577 rs940030 chr8:8546928 A/G cg06636001 chr8:8085503 FLJ10661 -0.49 -7.12 -0.37 6.86e-12 Mood instability; CRC cis rs1552244 0.572 rs12107622 chr3:10171898 T/A cg16606324 chr3:10149918 C3orf24 0.69 8.08 0.41 1.2e-14 Alzheimer's disease; CRC cis rs453301 0.598 rs2921383 chr8:8892221 C/T cg06636001 chr8:8085503 FLJ10661 0.55 8.02 0.4 1.87e-14 Joint mobility (Beighton score); CRC cis rs9911578 0.967 rs1588322 chr17:56990099 T/C cg12560992 chr17:57184187 TRIM37 0.91 16.91 0.68 1.27e-46 Intelligence (multi-trait analysis); CRC cis rs10197940 0.662 rs13555 chr2:152333304 C/A cg06191203 chr2:152266755 RIF1 -0.6 -8.79 -0.44 8.48e-17 Lung cancer; CRC cis rs79387448 0.745 rs78136548 chr2:103103740 T/G cg09003973 chr2:102972529 NA 0.93 9.06 0.45 1.18e-17 Gut microbiota (bacterial taxa); CRC cis rs2832191 0.636 rs8131295 chr21:30516819 A/T cg24692254 chr21:30365293 RNF160 -0.59 -8.59 -0.43 3.44e-16 Dental caries; CRC cis rs13082711 0.863 rs13062327 chr3:27495573 G/A cg02860705 chr3:27208620 NA 0.61 8.71 0.43 1.46e-16 Systolic blood pressure;Diastolic blood pressure;Blood pressure; CRC cis rs911555 0.755 rs10144051 chr14:103885931 A/C cg12935359 chr14:103987150 CKB -0.56 -9.03 -0.45 1.48e-17 Intelligence (multi-trait analysis); CRC trans rs783540 1.000 rs783531 chr15:83249119 C/T cg18393722 chr15:85113863 UBE2QP1 -0.37 -6.37 -0.33 6.54e-10 Schizophrenia; CRC cis rs2882667 0.728 rs13181830 chr5:138280416 A/G cg09476006 chr5:138032270 NA -0.56 -9.8 -0.48 4.59e-20 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs4862750 0.914 rs6837117 chr4:187872379 C/T cg03647317 chr4:187891568 NA -0.52 -9.44 -0.46 6.84e-19 Lobe attachment (rater-scored or self-reported); CRC cis rs9467773 0.526 rs3734536 chr6:26365346 C/G cg14345882 chr6:26364793 BTN3A2 0.42 6.45 0.33 4.08e-10 Intelligence (multi-trait analysis); CRC cis rs79349575 0.783 rs62075838 chr17:46996432 C/T cg22482690 chr17:47019901 SNF8 0.48 8.07 0.41 1.33e-14 Type 2 diabetes; CRC cis rs9902453 0.904 rs9897794 chr17:28296327 A/C cg26525008 chr17:28256777 EFCAB5;SSH2 0.68 11.15 0.52 1.01e-24 Coffee consumption (cups per day); CRC trans rs459571 0.959 rs2810491 chr9:136923331 C/T cg15028160 chr19:49622717 PPFIA3;C19orf73 0.53 6.9 0.36 2.72e-11 Platelet distribution width; CRC cis rs672059 1.000 rs3120034 chr1:183167051 A/G ch.1.3577855R chr1:183094577 LAMC1 0.6 8.39 0.42 1.45e-15 Hypertriglyceridemia; CRC cis rs2070488 0.804 rs7372452 chr3:38444298 C/G cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.73 12.44 0.57 2.31e-29 Electrocardiographic conduction measures; CRC cis rs11252926 0.528 rs11252090 chr10:436547 C/T cg18196295 chr10:418757 DIP2C -0.62 -9.69 -0.47 1.1e-19 Psychosis in Alzheimer's disease; CRC cis rs6163 0.588 rs11191392 chr10:104526951 C/A cg11453585 chr10:104263688 ACTR1A;SUFU -0.5 -7.65 -0.39 2.3e-13 Waist circumference;Hip circumference; CRC cis rs7937682 0.889 rs551825 chr11:111480116 C/G cg19812747 chr11:111475976 SIK2 -0.59 -10.14 -0.49 3.31e-21 Primary sclerosing cholangitis; CRC cis rs7945718 0.875 rs7924501 chr11:12813870 A/G cg25843174 chr11:12811716 TEAD1 0.48 9.09 0.45 9.27e-18 Educational attainment (years of education); CRC cis rs172166 0.637 rs1233691 chr6:28153897 T/G cg21251018 chr6:28226885 NKAPL 0.48 7.59 0.39 3.37e-13 Cardiac Troponin-T levels; CRC cis rs780096 0.526 rs11127013 chr2:27692973 A/G cg02592271 chr2:27665507 KRTCAP3 -0.27 -5.94 -0.31 7.17e-9 Total body bone mineral density; CRC cis rs9826463 0.582 rs73238161 chr3:142081981 A/C cg20824294 chr3:142316082 PLS1 0.36 5.85 0.31 1.21e-8 QRS duration in Tripanosoma cruzi seropositivity; CRC cis rs367943 0.966 rs455435 chr5:112799412 T/C cg12552261 chr5:112820674 MCC -0.5 -7.78 -0.39 9.28e-14 Type 2 diabetes; CRC cis rs12230513 0.793 rs7138601 chr12:55895730 A/T cg19537932 chr12:55886519 OR6C68 0.42 5.81 0.31 1.48e-8 Contrast sensitivity; CRC cis rs8072100 0.935 rs4793978 chr17:45698175 G/A cg25173405 chr17:45401733 C17orf57 0.43 6.58 0.34 1.88e-10 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC trans rs12517041 1.000 rs10059818 chr5:23292940 G/T ch.8.1293020R chr8:59333349 UBXN2B -0.55 -6.17 -0.32 2.05e-9 Calcium levels; CRC trans rs1005277 0.505 rs719569 chr10:38154415 T/G cg23533926 chr12:111358616 MYL2 0.45 6.65 0.34 1.25e-10 Extrinsic epigenetic age acceleration; CRC cis rs4604732 0.631 rs11490201 chr1:247626262 A/G cg12754571 chr1:247694271 LOC148824;OR2C3 0.41 5.75 0.3 2.04e-8 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CRC cis rs801193 0.935 rs11772264 chr7:66176387 T/C cg18876405 chr7:65276391 NA 0.6 10.49 0.5 2.08e-22 Aortic root size; CRC cis rs17095355 1.000 rs11194917 chr10:111692552 C/G cg00817464 chr10:111662876 XPNPEP1 -0.6 -7.8 -0.39 8.43e-14 Biliary atresia; CRC cis rs11122272 0.701 rs7414807 chr1:231476874 G/A cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.47 -6.9 -0.36 2.65e-11 Hemoglobin concentration; CRC cis rs7584330 0.868 rs58057291 chr2:238395479 T/A cg14458575 chr2:238380390 NA 0.76 13.32 0.59 1.16e-32 Prostate cancer; CRC trans rs561341 1.000 rs8077092 chr17:30281992 T/C cg20587970 chr11:113659929 NA -1.19 -17.19 -0.69 1e-47 Hip circumference adjusted for BMI; CRC cis rs853679 0.517 rs9380058 chr6:28127444 T/C cg06470822 chr6:28175283 NA 1.01 13.28 0.59 1.55e-32 Depression; CRC cis rs9560113 0.881 rs9560111 chr13:112181289 C/T cg10483660 chr13:112241077 NA 0.36 5.78 0.3 1.76e-8 Menarche (age at onset); CRC cis rs12824058 0.831 rs1390849 chr12:130811547 A/G cg24838063 chr12:130822603 PIWIL1 0.58 9.77 0.47 5.67e-20 Menopause (age at onset); CRC cis rs7113874 0.589 rs6578968 chr11:8480719 G/T cg02811074 chr11:8615871 STK33 -0.35 -5.96 -0.31 6.43e-9 Body mass index in physically active individuals;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs1862618 0.853 rs2548665 chr5:56131805 T/A cg22800045 chr5:56110881 MAP3K1 0.58 6.44 0.33 4.15e-10 Initial pursuit acceleration; CRC cis rs9611565 0.659 rs4822035 chr22:41935912 A/G cg06634786 chr22:41940651 POLR3H 0.65 7.49 0.38 6.24e-13 Vitiligo; CRC cis rs11098499 0.954 rs12502423 chr4:120424172 A/C cg24375607 chr4:120327624 NA 0.51 7.72 0.39 1.41e-13 Corneal astigmatism; CRC cis rs896854 1.000 rs13255935 chr8:95965685 C/A cg16049864 chr8:95962084 TP53INP1 -0.68 -12.29 -0.56 8.2e-29 Type 2 diabetes; CRC trans rs4332037 0.906 rs62442903 chr7:1953416 G/A cg11693508 chr17:37793320 STARD3 0.68 8.14 0.41 8.13e-15 Bipolar disorder; CRC cis rs459571 0.834 rs379417 chr9:136890704 G/A cg13789015 chr9:136890014 NCRNA00094 0.43 5.7 0.3 2.72e-8 Platelet distribution width; CRC cis rs243505 1.000 rs243507 chr7:148434600 G/A cg09806900 chr7:148480153 CUL1 -0.44 -6.19 -0.32 1.8e-9 Inflammatory bowel disease;Crohn's disease; CRC cis rs7216064 0.953 rs4791048 chr17:65848994 G/A cg12091567 chr17:66097778 LOC651250 -0.64 -7.85 -0.4 5.82e-14 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CRC cis rs9611565 0.659 rs17367716 chr22:41913844 A/G cg06481639 chr22:41940642 POLR3H -0.55 -6.43 -0.33 4.61e-10 Vitiligo; CRC cis rs2439831 0.850 rs7169322 chr15:44131014 T/C cg02155558 chr15:43621948 ADAL;LCMT2 0.69 7.46 0.38 7.65e-13 Lung cancer in ever smokers; CRC cis rs4285028 0.699 rs7637495 chr3:121573850 C/T cg11130432 chr3:121712080 ILDR1 -0.46 -5.86 -0.31 1.11e-8 Multiple sclerosis; CRC cis rs262150 0.819 rs6956589 chr7:158769301 C/T cg12590608 chr7:158785262 NA 0.49 9.04 0.45 1.36e-17 Facial morphology (factor 20); CRC cis rs2252521 0.524 rs1719570 chr7:29043363 T/G cg11728747 chr7:29037910 CPVL -0.49 -6.98 -0.36 1.66e-11 Cognitive performance; CRC cis rs1403694 1.000 rs2689197 chr3:186438346 C/T cg04611788 chr3:186434169 KNG1 -0.46 -7.02 -0.36 1.27e-11 Blood protein levels; CRC cis rs2204008 0.805 rs11179579 chr12:38213957 A/C cg13010199 chr12:38710504 ALG10B 0.45 5.72 0.3 2.37e-8 Bladder cancer; CRC cis rs6543140 0.964 rs2310301 chr2:103072935 C/T cg03938978 chr2:103052716 IL18RAP 0.41 6.54 0.34 2.37e-10 Blood protein levels; CRC cis rs514406 0.893 rs1242326 chr1:53399104 C/A cg27535305 chr1:53392650 SCP2 -0.4 -7.17 -0.37 4.85e-12 Monocyte count; CRC trans rs916888 0.773 rs199535 chr17:44822662 A/G cg07870213 chr5:140052090 DND1 0.98 11.37 0.53 1.72e-25 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC trans rs7726839 0.526 rs55647623 chr5:567747 T/C cg25482853 chr8:67687455 SGK3 0.97 12.23 0.56 1.36e-28 Obesity-related traits; CRC cis rs2180341 1.000 rs6569480 chr6:127621748 A/G cg27446573 chr6:127587934 RNF146 0.97 14.31 0.62 1.93e-36 Breast cancer; CRC cis rs10504229 0.639 rs56066782 chr8:58105857 A/G cg21724239 chr8:58056113 NA 0.52 6.99 0.36 1.58e-11 Developmental language disorder (linguistic errors); CRC cis rs9733 0.544 rs72700902 chr1:150633347 C/T cg18016565 chr1:150552671 MCL1 0.47 6.82 0.35 4.33e-11 Tonsillectomy; CRC trans rs1997103 0.954 rs10246216 chr7:55390479 C/T cg20935933 chr6:143382018 AIG1 0.5 6.47 0.34 3.65e-10 QRS interval (sulfonylurea treatment interaction); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg04582424 chr1:203764710 ZC3H11A 0.42 6.14 0.32 2.32e-9 Intelligence (multi-trait analysis); CRC trans rs629535 0.514 rs55653755 chr8:70154383 A/C cg21567404 chr3:27674614 NA -0.9 -13.02 -0.58 1.56e-31 Dupuytren's disease; CRC cis rs3733585 0.775 rs13124007 chr4:10043931 G/C cg11266682 chr4:10021025 SLC2A9 0.52 10.62 0.51 7.35e-23 Cleft plate (environmental tobacco smoke interaction); CRC cis rs4808199 0.895 rs6511036 chr19:19582651 A/G cg03709012 chr19:19516395 GATAD2A 1.0 11.99 0.55 1.01e-27 Nonalcoholic fatty liver disease; CRC cis rs7589728 0.563 rs80324973 chr2:88447264 T/G cg14558114 chr2:88469736 THNSL2 0.62 6.22 0.32 1.48e-9 Plasma clusterin levels; CRC cis rs7927771 0.896 rs12794570 chr11:47658314 C/T cg20307385 chr11:47447363 PSMC3 -0.56 -7.77 -0.39 1e-13 Subjective well-being; CRC cis rs2361718 0.500 rs8064429 chr17:78096187 A/C cg21238619 chr17:78079768 GAA -0.48 -8.53 -0.43 5.35e-16 Yeast infection; CRC cis rs6445525 0.806 rs9853428 chr3:66004122 C/G cg06109867 chr3:66002991 MAGI1 -0.37 -5.77 -0.3 1.84e-8 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs57221529 0.713 rs12522724 chr5:590742 T/C cg17948913 chr5:572064 NA 0.52 5.95 0.31 6.79e-9 Lung disease severity in cystic fibrosis; CRC trans rs7267979 0.966 rs6050611 chr20:25414419 A/G cg17903999 chr18:56338584 MALT1 -0.4 -6.5 -0.34 2.95e-10 Liver enzyme levels (alkaline phosphatase); CRC cis rs11148252 0.846 rs4886077 chr13:52998697 G/T cg00495681 chr13:53174319 NA 0.57 8.54 0.43 4.9e-16 Lewy body disease; CRC cis rs2836974 0.568 rs419469 chr21:40537234 C/T cg06238570 chr21:40685208 BRWD1 0.77 12.2 0.56 1.76e-28 Cognitive function; CRC cis rs12325245 0.536 rs71389028 chr16:58663260 G/A cg21335942 chr16:58549945 SETD6 0.86 5.72 0.3 2.39e-8 Schizophrenia; CRC cis rs7809950 0.678 rs79902674 chr7:106866498 A/C cg23024343 chr7:107201750 COG5 -0.7 -9.38 -0.46 1.07e-18 Coronary artery disease; CRC cis rs7247513 0.964 rs4804202 chr19:12718619 T/C cg01871581 chr19:12707946 ZNF490 -0.78 -13.23 -0.59 2.48e-32 Bipolar disorder; CRC cis rs853679 0.517 rs9380065 chr6:28144751 A/G cg12963246 chr6:28129442 ZNF389 0.5 5.75 0.3 2e-8 Depression; CRC cis rs938554 0.542 rs7678287 chr4:10000501 A/G cg11266682 chr4:10021025 SLC2A9 0.4 6.34 0.33 7.53e-10 Blood metabolite levels; CRC cis rs7208859 0.673 rs9899349 chr17:29200122 C/T cg13385521 chr17:29058706 SUZ12P 0.69 8.01 0.4 2.02e-14 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs7043114 0.507 rs7856204 chr9:95173814 G/C cg13798575 chr9:95087839 CENPP;NOL8 -0.4 -5.96 -0.31 6.43e-9 Height; CRC cis rs7917772 0.503 rs11191342 chr10:104344450 G/A cg04362960 chr10:104952993 NT5C2 -0.42 -5.92 -0.31 7.95e-9 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC cis rs8077889 0.672 rs15359 chr17:41843979 C/G cg25876840 chr17:41920477 NA -0.45 -7.11 -0.36 7.38e-12 Triglycerides; CRC cis rs1008375 1.000 rs2058339 chr4:17678456 C/T cg16339924 chr4:17578868 LAP3 0.51 6.69 0.35 9.44e-11 Parasitemia in Tripanosoma cruzi seropositivity; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg26300324 chr2:38152884 FAM82A1 0.46 6.77 0.35 6.02e-11 Response to antipsychotic treatment; CRC cis rs79349575 0.783 rs4255820 chr17:46996583 T/A cg22482690 chr17:47019901 SNF8 0.48 8.0 0.4 2.1e-14 Type 2 diabetes; CRC cis rs4664293 0.647 rs10199805 chr2:160427391 G/T cg08347373 chr2:160653686 CD302 -0.38 -6.41 -0.33 4.95e-10 Monocyte percentage of white cells; CRC cis rs1784581 0.532 rs7767219 chr6:162423088 T/C cg17173639 chr6:162384350 PARK2 0.6 9.67 0.47 1.27e-19 Itch intensity from mosquito bite; CRC cis rs9868809 0.881 rs7631574 chr3:48663046 A/G cg00383909 chr3:49044727 WDR6 -0.57 -6.23 -0.32 1.47e-9 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; CRC cis rs10791323 0.521 rs10894756 chr11:133745852 G/A cg15485101 chr11:133734466 NA 0.4 7.25 0.37 2.92e-12 Childhood ear infection; CRC cis rs9911578 1.000 rs4793950 chr17:56593111 T/C cg05425664 chr17:57184151 TRIM37 0.51 8.15 0.41 7.5e-15 Intelligence (multi-trait analysis); CRC trans rs7395662 0.504 rs11039701 chr11:48389838 A/G cg03929089 chr4:120376271 NA -0.46 -6.61 -0.34 1.57e-10 HDL cholesterol; CRC cis rs920590 0.684 rs7461774 chr8:19666645 G/A cg03894339 chr8:19674705 INTS10 0.41 5.68 0.3 3.04e-8 Acute lymphoblastic leukemia (childhood); CRC cis rs7786808 0.741 rs11769149 chr7:158227127 A/G cg09998033 chr7:158218633 PTPRN2 0.62 8.85 0.44 5.44e-17 Obesity-related traits; CRC cis rs6502050 0.835 rs10163496 chr17:80110867 G/A cg25804541 chr17:80189381 SLC16A3 -0.31 -5.97 -0.31 6.08e-9 Life satisfaction; CRC cis rs7072216 0.763 rs12259939 chr10:100169021 T/C cg26618903 chr10:100175079 PYROXD2 -0.55 -9.16 -0.45 5.81e-18 Metabolite levels; CRC cis rs2153535 0.580 rs9379222 chr6:8514788 T/C cg21535247 chr6:8435926 SLC35B3 0.48 7.31 0.37 2.09e-12 Motion sickness; CRC cis rs7249142 0.549 rs2238667 chr19:19282523 G/A cg26504305 chr19:19281019 LOC729991-MEF2B;MEF2B -0.43 -8.53 -0.43 5.4e-16 IgG glycosylation; CRC cis rs2281845 0.507 rs7547762 chr1:201088245 A/G cg22815214 chr1:201083145 CACNA1S 0.51 6.43 0.33 4.44e-10 Permanent tooth development; CRC cis rs11628318 0.570 rs2896450 chr14:103076595 T/C cg12046867 chr14:103022105 NA -0.77 -9.19 -0.45 4.46e-18 Platelet count; CRC cis rs6952808 0.895 rs12669518 chr7:1921429 G/C cg14004847 chr7:1930337 MAD1L1 -0.4 -5.65 -0.3 3.51e-8 Bipolar disorder and schizophrenia; CRC cis rs490234 0.702 rs4838279 chr9:128411726 G/A cg14078157 chr9:128172775 NA -0.41 -6.75 -0.35 6.7e-11 Mean arterial pressure; CRC cis rs7680126 0.596 rs917826 chr4:10295595 C/G cg00071950 chr4:10020882 SLC2A9 -0.45 -5.93 -0.31 7.47e-9 Urate levels in lean individuals;Urate levels in overweight individuals;Urate levels in obese individuals; CRC cis rs7107174 0.892 rs2512529 chr11:77977351 C/T cg02023728 chr11:77925099 USP35 0.51 7.42 0.38 1e-12 Testicular germ cell tumor; CRC cis rs4713118 0.662 rs9380046 chr6:28030499 T/C cg21251018 chr6:28226885 NKAPL 0.47 6.54 0.34 2.37e-10 Parkinson's disease; CRC cis rs875971 0.964 rs697969 chr7:65558478 C/A cg18912574 chr7:65842487 NCRNA00174 -0.37 -6.49 -0.34 3.13e-10 Aortic root size; CRC cis rs12188164 0.543 rs7728027 chr5:459943 T/C cg26850624 chr5:429559 AHRR 0.52 8.78 0.44 8.84e-17 Cystic fibrosis severity; CRC cis rs1799949 0.827 rs74252763 chr17:41402020 C/T cg23758822 chr17:41437982 NA 0.8 13.17 0.59 4.05e-32 Menopause (age at onset); CRC trans rs7726839 0.561 rs3915384 chr5:573395 G/T cg25482853 chr8:67687455 SGK3 0.95 11.67 0.54 1.41e-26 Obesity-related traits; CRC cis rs875971 1.000 rs697970 chr7:65560052 G/C cg18876405 chr7:65276391 NA -0.52 -8.83 -0.44 6.44e-17 Aortic root size; CRC trans rs72956618 1.000 rs28564588 chr2:207496342 G/A cg16073378 chr2:468413 NA -0.67 -6.43 -0.33 4.54e-10 Tonsillectomy; CRC cis rs2734839 1.000 rs2734839 chr11:113286490 C/T cg14159747 chr11:113255604 NA 0.43 7.4 0.38 1.13e-12 Information processing speed; CRC cis rs10028773 0.600 rs4001390 chr4:120265783 G/C cg24375607 chr4:120327624 NA 0.47 7.68 0.39 1.89e-13 Educational attainment; CRC cis rs12995491 0.731 rs12992162 chr2:88508773 G/C cg14558114 chr2:88469736 THNSL2 -0.41 -6.02 -0.32 4.55e-9 Response to metformin (IC50); CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg20195957 chr2:68694673 APLF;FBXO48 0.5 6.14 0.32 2.37e-9 Diisocyanate-induced asthma; CRC cis rs1348850 0.668 rs13034886 chr2:178493301 G/T cg22681709 chr2:178499509 PDE11A -0.35 -5.81 -0.3 1.5e-8 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs4713118 0.662 rs9357060 chr6:28024486 C/G cg23161317 chr6:28129485 ZNF389 0.45 5.81 0.3 1.5e-8 Parkinson's disease; CRC cis rs7811142 0.779 rs111312383 chr7:99905325 C/T cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.59 7.35 0.38 1.62e-12 Platelet count; CRC cis rs4423214 0.840 rs1619577 chr11:71181485 C/T cg13043300 chr11:71146211 DHCR7 -0.43 -5.82 -0.31 1.36e-8 Vitamin D levels; CRC cis rs9911578 0.835 rs9303398 chr17:56484257 T/C cg05425664 chr17:57184151 TRIM37 0.45 7.01 0.36 1.39e-11 Intelligence (multi-trait analysis); CRC cis rs3845702 1.000 rs10497555 chr2:180864967 A/G cg23417306 chr2:180868811 CWC22 0.49 6.69 0.35 9.5e-11 Schizophrenia; CRC cis rs875971 0.964 rs778723 chr7:65829497 T/C cg18912574 chr7:65842487 NCRNA00174 0.36 6.18 0.32 1.88e-9 Aortic root size; CRC cis rs11031096 0.754 rs10835611 chr11:4117730 G/C cg18678763 chr11:4115507 RRM1 -0.42 -7.2 -0.37 4.2e-12 Mean corpuscular volume;Mean corpuscular hemoglobin; CRC trans rs7615952 0.546 rs2979333 chr3:125360343 T/A cg07211511 chr3:129823064 LOC729375 -0.59 -6.9 -0.36 2.74e-11 Blood pressure (smoking interaction); CRC cis rs6495367 1.000 rs755362 chr15:79376601 C/T cg17916960 chr15:79447300 NA -0.4 -6.55 -0.34 2.22e-10 Spherical equivalent (joint analysis main effects and education interaction); CRC cis rs1707322 0.717 rs28396194 chr1:46213227 C/T cg06784218 chr1:46089804 CCDC17 0.65 12.05 0.55 5.8e-28 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs72781680 0.611 rs2303287 chr2:24302246 A/G cg06627628 chr2:24431161 ITSN2 0.54 6.34 0.33 7.78e-10 Lymphocyte counts; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg08655493 chr21:33765248 URB1;C21orf119 0.49 6.56 0.34 2.07e-10 Thyroid stimulating hormone; CRC cis rs7493 0.950 rs7785705 chr7:95033803 A/T cg20119798 chr7:94954144 PON1 -0.51 -6.4 -0.33 5.35e-10 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs5417 0.775 rs222852 chr17:7140606 A/G cg13768953 chr17:7114967 DLG4 -0.31 -5.99 -0.31 5.47e-9 Diastolic blood pressure; CRC cis rs3768617 0.510 rs4651139 chr1:183091963 C/T ch.1.3577855R chr1:183094577 LAMC1 0.89 15.86 0.66 1.84e-42 Fuchs's corneal dystrophy; CRC cis rs6076065 0.723 rs6083100 chr20:23358651 G/A cg11657817 chr20:23433608 CST11 0.45 6.79 0.35 5.39e-11 Facial morphology (factor 15, philtrum width); CRC trans rs2727020 0.563 rs10769582 chr11:49474040 T/C cg03929089 chr4:120376271 NA -0.88 -16.49 -0.67 5.93e-45 Coronary artery disease; CRC cis rs477895 0.653 rs11606544 chr11:63896901 C/T cg04317338 chr11:64019027 PLCB3 0.6 7.36 0.38 1.47e-12 Mean platelet volume; CRC cis rs10791323 0.536 rs4937842 chr11:133734542 C/G cg03690763 chr11:133734501 NA 0.44 7.75 0.39 1.15e-13 Childhood ear infection; CRC cis rs600806 0.850 rs3768493 chr1:109935505 C/T cg23032129 chr1:109941072 SORT1 -0.28 -6.06 -0.32 3.68e-9 Intelligence (multi-trait analysis); CRC cis rs6500602 0.701 rs8053770 chr16:4539030 T/A cg13763550 chr16:4524223 NMRAL1;HMOX2 0.43 5.73 0.3 2.31e-8 Schizophrenia; CRC trans rs17270561 0.636 rs9393671 chr6:25789189 G/C cg02936872 chr9:99801550 CTSL2 -0.48 -6.18 -0.32 1.85e-9 Iron status biomarkers; CRC trans rs12940923 0.872 rs59775965 chr17:56370439 T/C cg16900910 chr15:72789182 ARIH1 0.52 5.97 0.31 6.14e-9 Circulating myeloperoxidase levels (plasma); CRC cis rs67311347 1.000 rs4974017 chr3:40473519 C/T cg09455208 chr3:40491958 NA 0.44 8.94 0.44 2.84e-17 Renal cell carcinoma; CRC cis rs9611565 0.532 rs4401299 chr22:42156517 A/G cg03806693 chr22:41940476 POLR3H 0.65 9.06 0.45 1.22e-17 Vitiligo; CRC cis rs9814567 1.000 rs13059720 chr3:134242021 T/G cg06109529 chr3:134205091 CEP63;ANAPC13 0.83 12.22 0.56 1.46e-28 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs9479482 0.967 rs1853664 chr6:150355266 A/G cg25797454 chr6:150327115 RAET1K 0.36 6.32 0.33 8.68e-10 Alopecia areata; CRC cis rs7937682 0.855 rs539693 chr11:111477387 A/G cg09085632 chr11:111637200 PPP2R1B -0.98 -19.21 -0.73 1.09e-55 Primary sclerosing cholangitis; CRC cis rs4423214 1.000 rs12792306 chr11:71166992 T/C cg05163923 chr11:71159392 DHCR7 0.68 9.66 0.47 1.34e-19 Vitamin D levels; CRC cis rs13268772 0.520 rs7819673 chr8:3241798 C/T cg23564432 chr8:3253958 CSMD1 0.35 5.75 0.3 2.05e-8 Schizophrenia; CRC trans rs11039798 1.000 rs12280020 chr11:48618844 G/C cg03929089 chr4:120376271 NA 0.63 6.33 0.33 8.23e-10 Axial length; CRC cis rs11030122 0.604 rs10835557 chr11:4083121 A/G cg18678763 chr11:4115507 RRM1 -0.56 -8.99 -0.44 2.06e-17 Mean platelet volume;Platelet distribution width; CRC cis rs10782582 0.593 rs11579752 chr1:76178694 C/T cg05598546 chr1:76251766 SNORD45C;RABGGTB 0.44 5.62 0.3 3.98e-8 Daytime sleep phenotypes; CRC cis rs929596 0.531 rs2741022 chr2:234514273 C/T cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.44 -5.76 -0.3 1.95e-8 Total bilirubin levels in HIV-1 infection; CRC cis rs9311474 0.607 rs4234633 chr3:52557038 C/T cg11645453 chr3:52864694 ITIH4 0.33 5.79 0.3 1.66e-8 Electroencephalogram traits; CRC cis rs4713118 0.869 rs9295743 chr6:27715102 G/C cg08798685 chr6:27730294 NA -0.43 -6.3 -0.33 9.81e-10 Parkinson's disease; CRC cis rs3806843 1.000 rs3733707 chr5:140181892 T/C cg16607685 chr5:140181889 PCDHA2;PCDHA1;PCDHA3 -0.27 -6.23 -0.32 1.4e-9 Depressive symptoms (multi-trait analysis); CRC cis rs11155671 0.530 rs7758033 chr6:150208135 T/C cg19673125 chr6:150240577 RAET1G 0.3 5.72 0.3 2.41e-8 Testicular germ cell tumor; CRC cis rs10046574 0.831 rs10243569 chr7:135063466 G/A cg27474649 chr7:135195673 CNOT4 0.69 5.74 0.3 2.14e-8 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs2404602 0.583 rs2456076 chr15:76557553 T/G cg00316803 chr15:76480434 C15orf27 0.39 6.85 0.35 3.72e-11 Blood metabolite levels; CRC cis rs12519773 0.501 rs10428523 chr5:92536365 G/A cg18783429 chr5:92414398 NA 0.27 5.77 0.3 1.79e-8 Migraine; CRC cis rs2204008 0.583 rs12307593 chr12:38317803 A/G cg26384229 chr12:38710491 ALG10B 0.51 7.72 0.39 1.43e-13 Bladder cancer; CRC cis rs2976388 0.609 rs2585144 chr8:143800269 A/T cg20041105 chr8:143859282 LYNX1 0.46 8.12 0.41 9.33e-15 Urinary tract infection frequency; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg08205230 chr11:67183078 ATPGD1 -0.41 -6.3 -0.33 9.41e-10 Myopia (pathological); CRC cis rs6860806 0.661 rs2136188 chr5:131577514 A/G cg11843238 chr5:131593191 PDLIM4 -0.43 -8.16 -0.41 7.09e-15 Breast cancer; CRC cis rs2731664 0.792 rs335468 chr5:176892349 A/G cg23176889 chr5:176863531 GRK6 0.74 16.1 0.66 2.04e-43 Intelligence (multi-trait analysis); CRC cis rs1949733 0.635 rs4358384 chr4:8536913 C/T cg13073564 chr4:8508604 NA 0.39 5.81 0.3 1.51e-8 Response to antineoplastic agents; CRC cis rs2180341 0.855 rs4308584 chr6:127714874 A/G cg24812749 chr6:127587940 RNF146 0.67 9.17 0.45 5.29e-18 Breast cancer; CRC trans rs7618501 0.633 rs2008877 chr3:50162291 T/G cg21665057 chr3:196295764 WDR53;FBXO45 -0.61 -9.49 -0.46 4.75e-19 Intelligence (multi-trait analysis); CRC cis rs7312933 1.000 rs10880230 chr12:42450253 G/A cg01256987 chr12:42539512 GXYLT1 -0.44 -6.6 -0.34 1.65e-10 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CRC cis rs2455601 0.744 rs7938995 chr11:8975675 T/G cg09997546 chr11:8931473 C11orf17;ST5 -0.46 -6.18 -0.32 1.84e-9 Schizophrenia; CRC cis rs1215050 0.791 rs7688942 chr4:98832048 T/C cg05340658 chr4:99064831 C4orf37 0.45 6.74 0.35 6.98e-11 Waist-to-hip ratio adjusted for body mass index; CRC cis rs561341 1.000 rs560132 chr17:30320019 C/T cg23018236 chr17:30244563 NA -0.67 -8.09 -0.41 1.19e-14 Hip circumference adjusted for BMI; CRC cis rs5758659 0.652 rs133358 chr22:42442539 A/T cg15557168 chr22:42548783 NA -0.35 -5.72 -0.3 2.4e-8 Cognitive function; CRC trans rs492478 0.892 rs114618260 chr5:3911191 A/G cg09199442 chr11:28132951 METT5D1 -0.72 -6.15 -0.32 2.26e-9 Cognitive performance; CRC cis rs13108904 0.521 rs4974609 chr4:1356924 A/C cg21620606 chr4:1342894 KIAA1530 -0.42 -7.42 -0.38 1.04e-12 Obesity-related traits; CRC cis rs929354 0.713 rs3802129 chr7:156965297 G/A cg17757837 chr7:157058334 UBE3C 0.72 12.12 0.56 3.35e-28 Body mass index; CRC cis rs3008870 0.755 rs4655660 chr1:67402953 G/A cg08660285 chr1:67390436 MIER1;WDR78 0.55 7.72 0.39 1.37e-13 Lymphocyte percentage of white cells; CRC cis rs3812049 0.737 rs790155 chr5:127498380 C/T cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.73 9.02 0.45 1.6e-17 Lymphocyte counts;Red cell distribution width; CRC cis rs4713118 0.513 rs200971 chr6:27858904 C/T cg06470822 chr6:28175283 NA 0.79 11.24 0.53 5.09e-25 Parkinson's disease; CRC cis rs2204008 0.712 rs12371182 chr12:38321143 A/C cg26384229 chr12:38710491 ALG10B 0.68 9.05 0.45 1.25e-17 Bladder cancer; CRC cis rs1577917 1.000 rs2812972 chr6:86669880 A/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.51 -6.89 -0.36 2.82e-11 Response to antipsychotic treatment; CRC cis rs904251 0.561 rs4714070 chr6:37473198 C/T cg01843034 chr6:37503916 NA -0.37 -6.34 -0.33 7.43e-10 Cognitive performance; CRC cis rs7692995 1.000 rs7686082 chr4:17957576 C/T cg08925142 chr4:18023851 LCORL -0.53 -5.85 -0.31 1.2e-8 Height; CRC cis rs77861329 0.748 rs4687805 chr3:52123313 A/G cg08692210 chr3:52188851 WDR51A 0.53 6.01 0.31 4.85e-9 Macrophage inflammatory protein 1b levels; CRC cis rs75920871 0.528 rs7941428 chr11:116903384 C/G cg01368799 chr11:117014884 PAFAH1B2 -0.41 -5.84 -0.31 1.26e-8 Subjective well-being; CRC cis rs11628318 0.660 rs12887323 chr14:103083322 T/C cg23461800 chr14:103021989 NA -0.7 -8.05 -0.41 1.57e-14 Platelet count; CRC cis rs9611565 0.649 rs79009 chr22:41860864 C/A cg06634786 chr22:41940651 POLR3H 0.66 7.9 0.4 4.31e-14 Vitiligo; CRC cis rs7605827 0.897 rs11682528 chr2:15533183 T/C cg19274914 chr2:15703543 NA 0.39 5.72 0.3 2.39e-8 Educational attainment (years of education); CRC cis rs709400 1.000 rs2403205 chr14:104143385 C/T cg12935359 chr14:103987150 CKB -0.4 -6.73 -0.35 7.55e-11 Body mass index; CRC cis rs9322193 1.000 rs9377228 chr6:149921998 G/A cg00933542 chr6:150070202 PCMT1 0.29 6.05 0.32 3.94e-9 Lung cancer; CRC cis rs6754311 0.731 rs3754686 chr2:136603276 T/C cg25344623 chr2:136566232 LCT 0.33 5.99 0.31 5.61e-9 Mosquito bite size; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg27397625 chr6:42952298 PPP2R5D 0.47 6.87 0.35 3.3e-11 Response to antipsychotic treatment; CRC cis rs208520 0.706 rs851601 chr6:66893853 G/A cg07460842 chr6:66804631 NA -0.93 -12.48 -0.57 1.55e-29 Exhaled nitric oxide output; CRC cis rs9902453 0.845 rs3115101 chr17:28041627 G/A cg26525008 chr17:28256777 EFCAB5;SSH2 0.58 8.73 0.43 1.3e-16 Coffee consumption (cups per day); CRC trans rs2727020 0.894 rs11040333 chr11:49346332 G/A cg03929089 chr4:120376271 NA -0.72 -9.58 -0.47 2.55e-19 Coronary artery disease; CRC cis rs7918232 0.627 rs6482588 chr10:27308307 G/C cg14442939 chr10:27389572 ANKRD26 0.64 6.95 0.36 1.91e-11 Breast cancer; CRC trans rs875971 0.545 rs10950036 chr7:65818228 G/T cg02869306 chr7:64672164 INTS4L1 -0.43 -6.24 -0.33 1.37e-9 Aortic root size; CRC cis rs8005677 1.000 rs2295683 chr14:23388382 A/C cg25600027 chr14:23388339 RBM23 -0.53 -8.3 -0.42 2.72e-15 Cognitive ability (multi-trait analysis); CRC cis rs873946 0.648 rs12769533 chr10:134548685 C/T cg18305652 chr10:134549665 INPP5A -0.53 -7.26 -0.37 2.85e-12 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CRC cis rs736408 0.609 rs1029871 chr3:52797634 G/C cg07507251 chr3:52567010 NT5DC2 0.44 6.28 0.33 1.05e-9 Bipolar disorder; CRC cis rs1878931 0.501 rs9921169 chr16:3421261 A/T cg26668626 chr16:3451006 ZNF174;ZNF434 0.7 9.59 0.47 2.25e-19 Body mass index (adult); CRC cis rs853679 0.550 rs1150692 chr6:28173957 A/G cg06470822 chr6:28175283 NA 0.95 13.82 0.61 1.39e-34 Depression; CRC cis rs7811142 1.000 rs60844404 chr7:100080474 A/T cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.92 12.27 0.56 9.74e-29 Platelet count; CRC cis rs8072100 1.000 rs11870935 chr17:45732605 G/A cg08085267 chr17:45401833 C17orf57 0.65 10.69 0.51 4.22e-23 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs9928842 0.882 rs9319481 chr16:75259478 T/C cg09066997 chr16:75300724 BCAR1 0.7 6.62 0.34 1.49e-10 Alcoholic chronic pancreatitis; CRC cis rs2836974 0.644 rs11088472 chr21:40699376 A/C cg11644478 chr21:40555479 PSMG1 -0.64 -10.12 -0.49 3.79e-21 Cognitive function; CRC cis rs60843830 0.928 rs62114494 chr2:211317 C/T cg25945732 chr2:264204 ACP1;SH3YL1 0.7 11.09 0.52 1.64e-24 Spherical equivalent (joint analysis main effects and education interaction); CRC cis rs875971 0.505 rs6955582 chr7:65431686 A/G cg00343986 chr7:65444356 GUSB 0.57 8.6 0.43 3.21e-16 Aortic root size; CRC cis rs60871478 1.000 rs4720930 chr7:808073 G/A cg13844804 chr7:814759 HEATR2 0.67 8.61 0.43 3.1e-16 Cerebrospinal P-tau181p levels; CRC cis rs7493 0.950 rs17166868 chr7:95033416 C/T cg04155289 chr7:94953770 PON1 -0.62 -7.79 -0.39 8.77e-14 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs2180341 0.960 rs9401953 chr6:127687574 G/A cg24812749 chr6:127587940 RNF146 0.92 13.17 0.59 4.28e-32 Breast cancer; CRC cis rs554111 0.891 rs646786 chr1:21054726 A/G cg00373020 chr1:21041521 KIF17 0.36 5.7 0.3 2.67e-8 Facial morphology (factor 17, height of vermillion upper lip); CRC cis rs13118159 0.778 rs12650998 chr4:1338832 T/C cg20092199 chr4:1342459 KIAA1530 0.33 5.85 0.31 1.17e-8 Longevity; CRC cis rs7223966 1.000 rs8081541 chr17:61812483 C/T cg23090583 chr17:61904693 PSMC5;FTSJ3 0.49 6.02 0.32 4.53e-9 Hip circumference adjusted for BMI;Body mass index; CRC cis rs11148252 0.538 rs2296348 chr13:52710136 T/G cg02158880 chr13:53174818 NA 0.39 5.6 0.3 4.51e-8 Lewy body disease; CRC cis rs9322193 0.923 rs9689723 chr6:149977071 C/A cg05861140 chr6:150128134 PCMT1 -0.37 -5.94 -0.31 7.18e-9 Lung cancer; CRC cis rs208515 0.525 rs12191500 chr6:66668681 A/G cg07460842 chr6:66804631 NA 0.96 12.08 0.55 4.81e-28 Exhaled nitric oxide levels; CRC cis rs13031619 0.950 rs7589966 chr2:3696636 A/G cg10645314 chr2:3704589 ALLC 0.52 6.79 0.35 5.29e-11 Response to inhaled corticosteroid treatment in asthma (change in FEV1); CRC cis rs7666738 0.830 rs7663661 chr4:99014761 A/G cg17366294 chr4:99064904 C4orf37 0.44 7.35 0.38 1.55e-12 Colonoscopy-negative controls vs population controls; CRC cis rs7914558 1.000 rs4917380 chr10:104775335 C/G cg04362960 chr10:104952993 NT5C2 0.6 9.07 0.45 1.13e-17 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs6952808 0.862 rs4721167 chr7:1933224 C/T cg22963979 chr7:1858916 MAD1L1 -0.5 -7.52 -0.38 5.37e-13 Bipolar disorder and schizophrenia; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg13792596 chr14:64660940 SYNE2 0.39 6.02 0.31 4.59e-9 Liver disease severity in Alagille syndrome; CRC cis rs7647973 0.593 rs1799844 chr3:49847642 G/A cg13072238 chr3:49761600 GMPPB 0.51 5.61 0.3 4.24e-8 Menarche (age at onset); CRC cis rs12541635 1.000 rs11992752 chr8:107083122 G/A cg10147462 chr8:107024639 NA -0.39 -6.45 -0.33 4.08e-10 Age of smoking initiation; CRC cis rs739401 0.572 rs739400 chr11:3016520 G/A cg25174290 chr11:3078921 CARS 0.46 7.19 0.37 4.49e-12 Longevity; CRC cis rs798554 0.686 rs2644298 chr7:2858448 G/C cg19717773 chr7:2847554 GNA12 -0.48 -8.18 -0.41 6.46e-15 Height; CRC cis rs10256972 0.516 rs12702081 chr7:1141528 T/C cg03923535 chr7:1197113 ZFAND2A 0.63 9.05 0.45 1.27e-17 Longevity;Endometriosis; CRC cis rs898097 0.812 rs56405605 chr17:80843663 T/C cg03160526 chr17:80928410 B3GNTL1 -0.41 -5.84 -0.31 1.24e-8 Breast cancer; CRC cis rs4713118 0.869 rs6902689 chr6:27709441 C/T cg25164649 chr6:28176230 NA 0.6 8.42 0.42 1.16e-15 Parkinson's disease; CRC cis rs7647973 1.000 rs940045 chr3:49449638 G/A cg07690219 chr3:49449608 TCTA;RHOA -0.53 -6.24 -0.33 1.36e-9 Menarche (age at onset); CRC cis rs612683 0.560 rs491675 chr1:100902936 A/G cg06223162 chr1:101003688 GPR88 0.39 6.96 0.36 1.89e-11 Breast cancer; CRC cis rs6502050 0.764 rs28676462 chr17:80105100 G/C cg09264619 chr17:80180166 NA -0.34 -5.81 -0.3 1.5e-8 Life satisfaction; CRC cis rs7980687 0.662 rs585522 chr12:123550813 A/G cg00376283 chr12:123451042 ABCB9 0.58 7.72 0.39 1.45e-13 Height;Educational attainment;Head circumference (infant); CRC cis rs9916302 0.851 rs9909064 chr17:37500434 G/T cg03013999 chr17:37608204 MED1 -0.48 -7.42 -0.38 9.94e-13 Glomerular filtration rate (creatinine); CRC cis rs6831352 0.918 rs13133647 chr4:100058727 C/T cg12011299 chr4:100065546 ADH4 -0.49 -9.27 -0.45 2.61e-18 Alcohol dependence; CRC cis rs561341 1.000 rs546748 chr17:30324293 A/C cg00745463 chr17:30367425 LRRC37B -0.61 -7.86 -0.4 5.66e-14 Hip circumference adjusted for BMI; CRC cis rs4363385 0.818 rs2711 chr1:153005156 C/T cg25856811 chr1:152973957 SPRR3 -0.25 -6.93 -0.36 2.19e-11 Inflammatory skin disease; CRC cis rs262150 0.837 rs2657404 chr7:158783155 C/T cg10570241 chr7:158785291 NA 0.51 9.12 0.45 7.86e-18 Facial morphology (factor 20); CRC cis rs17711722 0.522 rs62469933 chr7:65265639 G/A cg24585817 chr7:64895279 NA 0.36 5.67 0.3 3.14e-8 Calcium levels; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg07450219 chr17:78428858 NA 0.43 7.19 0.37 4.34e-12 Liver disease severity in Alagille syndrome; CRC cis rs2239547 0.522 rs6768844 chr3:53004620 A/G cg18404041 chr3:52824283 ITIH1 0.33 6.27 0.33 1.15e-9 Schizophrenia; CRC cis rs7216064 1.000 rs35243555 chr17:65876477 G/C cg12091567 chr17:66097778 LOC651250 -0.67 -7.74 -0.39 1.24e-13 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CRC cis rs7208859 0.673 rs999797 chr17:29159329 G/A cg13385521 chr17:29058706 SUZ12P 0.69 8.04 0.41 1.59e-14 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs9942416 0.660 rs2307113 chr5:74998264 C/T cg19683494 chr5:74908142 NA 0.46 5.82 0.31 1.37e-8 Age-related disease endophenotypes; CRC cis rs1949733 1.000 rs6447875 chr4:8503206 T/C cg11789530 chr4:8429930 ACOX3 0.85 12.82 0.58 8.9e-31 Response to antineoplastic agents; CRC cis rs8177253 0.829 rs9882812 chr3:133506127 A/G cg11941060 chr3:133502564 NA -0.67 -11.57 -0.54 3.4e-26 Iron status biomarkers; CRC cis rs11031096 0.542 rs11828337 chr11:3976974 T/G cg18678763 chr11:4115507 RRM1 -0.39 -6.69 -0.35 9.38e-11 Mean corpuscular volume;Mean corpuscular hemoglobin; CRC cis rs910316 1.000 rs10136948 chr14:75511075 C/T cg03030879 chr14:75389066 RPS6KL1 -0.44 -6.85 -0.35 3.54e-11 Height; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg13340481 chr17:27275985 PHF12 0.43 6.65 0.34 1.21e-10 Intelligence (multi-trait analysis); CRC cis rs12044355 0.892 rs12048349 chr1:231850323 G/A cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX 0.45 6.03 0.32 4.49e-9 Alzheimer's disease; CRC cis rs12142240 0.698 rs67142569 chr1:46828460 C/T cg14993813 chr1:46806288 NSUN4 -0.49 -6.26 -0.33 1.21e-9 Menopause (age at onset); CRC cis rs10504229 0.815 rs16921955 chr8:58164553 C/T cg21724239 chr8:58056113 NA 0.4 5.97 0.31 6.13e-9 Developmental language disorder (linguistic errors); CRC cis rs1552244 1.000 rs7622963 chr3:10139825 C/T cg08888203 chr3:10149979 C3orf24 0.67 9.77 0.47 6.02e-20 Alzheimer's disease; CRC cis rs7215564 0.908 rs35112467 chr17:78677562 C/T cg09596252 chr17:78655493 RPTOR 0.55 6.09 0.32 3.09e-9 Myopia (pathological); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg00629816 chr9:37784931 EXOSC3 0.44 6.15 0.32 2.19e-9 Response to antipsychotic treatment; CRC cis rs2204008 0.728 rs11495375 chr12:38282631 G/A cg26384229 chr12:38710491 ALG10B 0.69 9.22 0.45 3.69e-18 Bladder cancer; CRC cis rs6912958 0.781 rs9444504 chr6:88181046 A/C cg08069147 chr6:88032118 GJB7;C6orf162 -0.55 -8.06 -0.41 1.4e-14 Monocyte percentage of white cells; CRC cis rs172166 0.637 rs1225597 chr6:28162087 C/T cg06470822 chr6:28175283 NA 0.87 13.71 0.6 3.75e-34 Cardiac Troponin-T levels; CRC cis rs7666738 0.830 rs2865978 chr4:99017946 G/T cg17366294 chr4:99064904 C4orf37 0.43 7.29 0.37 2.28e-12 Colonoscopy-negative controls vs population controls; CRC cis rs6089584 0.850 rs6142938 chr20:60627723 A/C cg23262073 chr20:60523788 NA -0.48 -7.57 -0.39 3.7e-13 Body mass index; CRC cis rs902774 0.818 rs73110471 chr12:53316821 G/A cg16329197 chr12:53359506 NA -0.59 -6.46 -0.34 3.78e-10 Prostate cancer; CRC cis rs9788721 0.640 rs1394371 chr15:78724469 C/T cg18825076 chr15:78729989 IREB2 -0.47 -6.44 -0.33 4.25e-10 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio;Emphysema imaging phenotypes;Emphysema distribution in smoking;Local histogram emphysema pattern;Post bronchodilator FEV1/FVC ratio in COPD; CRC cis rs4853012 0.838 rs61521879 chr2:74346208 T/C cg05890377 chr2:74357713 NA 0.59 9.76 0.47 6.31e-20 Gestational age at birth (maternal effect); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg02577203 chr11:47869805 NUP160 0.52 7.44 0.38 8.72e-13 Response to antipsychotic treatment; CRC cis rs798554 0.679 rs2266922 chr7:2824707 G/A cg04166393 chr7:2884313 GNA12 0.4 6.07 0.32 3.51e-9 Height; CRC cis rs853679 0.550 rs9295762 chr6:28155418 C/T cg02683197 chr6:28174875 NA -0.85 -11.6 -0.54 2.59e-26 Depression; CRC cis rs3540 0.618 rs11636089 chr15:91039527 C/T cg22089800 chr15:90895588 ZNF774 0.56 9.35 0.46 1.36e-18 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; CRC cis rs116095464 0.558 rs7356696 chr5:284251 A/G cg22857025 chr5:266934 NA -1.24 -16.52 -0.67 4.4e-45 Breast cancer; CRC cis rs6951245 1.000 rs79327308 chr7:1108141 A/C cg22907277 chr7:1156413 C7orf50 0.74 7.89 0.4 4.63e-14 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs59104589 0.583 rs61689231 chr2:242244583 G/A cg19488206 chr2:242435732 STK25 0.48 6.72 0.35 7.88e-11 Fibrinogen levels; CRC cis rs933688 1.000 rs10045280 chr5:90717675 T/A cg02339078 chr5:90679543 LOC100129716;ARRDC3 0.9 15.17 0.64 8.74e-40 Smoking behavior; CRC cis rs13256369 0.760 rs7839473 chr8:8575836 C/T cg06636001 chr8:8085503 FLJ10661 0.44 5.7 0.3 2.72e-8 Obesity-related traits; CRC cis rs752010 0.806 rs4457567 chr1:42091407 C/T cg06885757 chr1:42089581 HIVEP3 0.46 8.25 0.41 3.83e-15 Lupus nephritis in systemic lupus erythematosus; CRC cis rs11785400 0.928 rs750529 chr8:143744877 G/C cg10596483 chr8:143751796 JRK 0.49 6.94 0.36 2.09e-11 Schizophrenia; CRC cis rs2303759 0.709 rs7256363 chr19:49827804 C/T cg22307029 chr19:49891270 CCDC155 0.68 9.05 0.45 1.32e-17 Multiple sclerosis; CRC cis rs1218582 0.741 rs10908447 chr1:154869742 C/T cg16680214 chr1:154839983 KCNN3 -0.51 -9.51 -0.46 4.1e-19 Prostate cancer; CRC cis rs1059312 0.808 rs12831705 chr12:129294905 G/A cg23521905 chr12:129298690 SLC15A4;MGC16384 0.37 6.4 0.33 5.31e-10 Systemic lupus erythematosus; CRC cis rs8180040 0.726 rs2305634 chr3:47043538 A/G cg02527881 chr3:46936655 PTH1R 0.39 6.9 0.36 2.65e-11 Colorectal cancer; CRC trans rs12517041 1.000 rs7734577 chr5:23290864 A/G ch.8.1293020R chr8:59333349 UBXN2B -0.55 -6.17 -0.32 2.05e-9 Calcium levels; CRC cis rs7618915 0.547 rs62253733 chr3:52653414 A/G cg05573699 chr3:52720067 GNL3;PBRM1 -0.44 -6.22 -0.32 1.47e-9 Bipolar disorder; CRC cis rs12505749 0.542 rs6824893 chr4:57372243 A/G cg06922635 chr4:57371607 ARL9 -0.54 -5.77 -0.3 1.87e-8 Airflow obstruction; CRC cis rs9322193 0.923 rs2151913 chr6:150130642 C/T cg07701084 chr6:150067640 NUP43 0.48 6.8 0.35 5.05e-11 Lung cancer; CRC cis rs6502050 0.835 rs11658335 chr17:80084821 C/T cg02741985 chr17:80059408 CCDC57 -0.44 -7.15 -0.37 5.61e-12 Life satisfaction; CRC cis rs490234 0.812 rs12341150 chr9:128340770 C/T cg14078157 chr9:128172775 NA -0.4 -6.75 -0.35 6.85e-11 Mean arterial pressure; CRC cis rs13191362 1.000 rs66534429 chr6:163003322 A/G cg23758597 chr6:163146217 PARK2 -0.51 -5.91 -0.31 8.56e-9 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs7945705 0.935 rs1883098 chr11:8890594 G/A cg00186954 chr11:8933980 ST5;C11orf17 -0.46 -7.47 -0.38 7.27e-13 Hemoglobin concentration; CRC cis rs10046574 0.831 rs113826521 chr7:135167999 T/C cg27474649 chr7:135195673 CNOT4 0.69 5.7 0.3 2.61e-8 Peripheral arterial disease (traffic-related air pollution interaction); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg06611277 chr10:26987120 PDSS1 0.44 6.26 0.33 1.21e-9 Response to antipsychotic treatment; CRC trans rs79976124 0.879 rs17432710 chr6:66621744 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.77 9.47 0.46 5.67e-19 Type 2 diabetes; CRC cis rs2721195 0.719 rs4925811 chr8:145802447 G/T cg17328964 chr8:145687451 CYHR1 0.54 8.68 0.43 1.89e-16 Age at first birth; CRC cis rs13118159 0.509 rs1882098 chr4:1352431 T/C cg16405210 chr4:1374714 KIAA1530 -0.92 -14.44 -0.62 5.78e-37 Longevity; CRC cis rs7580658 0.817 rs6761447 chr2:128074573 A/T cg09760422 chr2:128146352 NA -0.29 -5.69 -0.3 2.81e-8 Protein C levels; CRC cis rs6952808 0.595 rs2398705 chr7:2164995 G/A cg02951883 chr7:2050386 MAD1L1 -0.69 -10.68 -0.51 4.82e-23 Bipolar disorder and schizophrenia; CRC cis rs501120 0.564 rs4948857 chr10:44683281 C/T cg09554077 chr10:44749378 NA 0.55 7.67 0.39 1.95e-13 Coronary artery disease;Coronary heart disease; CRC cis rs7677751 0.806 rs4864862 chr4:55100489 G/A cg13615338 chr4:55094005 PDGFRA 0.4 5.62 0.3 3.97e-8 Corneal astigmatism; CRC cis rs4604732 0.589 rs78689516 chr1:247626274 C/T cg02104434 chr1:247694406 LOC148824;OR2C3 0.6 8.85 0.44 5.65e-17 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CRC cis rs12681287 0.640 rs7833049 chr8:87445898 T/C cg27223183 chr8:87520930 FAM82B 0.52 7.44 0.38 8.7e-13 Caudate activity during reward; CRC cis rs4319547 0.695 rs4758645 chr12:122946487 G/A cg05707623 chr12:122985044 ZCCHC8 -0.54 -7.17 -0.37 4.87e-12 Body mass index; CRC trans rs66887589 0.616 rs11098497 chr4:120187068 C/T cg25214090 chr10:38739885 LOC399744 0.4 6.12 0.32 2.7e-9 Diastolic blood pressure; CRC cis rs798554 1.000 rs798536 chr7:2766383 G/A cg19717773 chr7:2847554 GNA12 -0.43 -6.13 -0.32 2.46e-9 Height; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg13030908 chr1:11741533 MAD2L2 0.5 6.44 0.33 4.34e-10 Thyroid stimulating hormone; CRC cis rs7811142 0.779 rs28680963 chr7:99905475 C/G cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.11 15.28 0.64 3.21e-40 Platelet count; CRC cis rs992157 0.835 rs7585702 chr2:219146607 T/C cg13835894 chr2:219148914 PNKD;TMBIM1 -0.36 -6.81 -0.35 4.78e-11 Colorectal cancer; CRC cis rs1580019 0.813 rs2044839 chr7:32500805 A/C cg07520158 chr7:32535189 LSM5;AVL9 0.52 7.01 0.36 1.35e-11 Cognitive ability; CRC cis rs883565 0.655 rs6768957 chr3:39100094 G/A cg01426195 chr3:39028469 NA -0.54 -8.77 -0.44 9.79e-17 Handedness; CRC cis rs68170813 0.559 rs75154004 chr7:106903326 C/T cg02696742 chr7:106810147 HBP1 -0.6 -6.65 -0.34 1.25e-10 Coronary artery disease; CRC cis rs13108904 0.901 rs1316394 chr4:1315820 G/A cg05665937 chr4:1216051 CTBP1 0.39 5.71 0.3 2.49e-8 Obesity-related traits; CRC cis rs7917772 0.582 rs7907417 chr10:104370662 A/G cg11453585 chr10:104263688 ACTR1A;SUFU -0.82 -15.01 -0.64 3.72e-39 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC cis rs10791323 0.604 rs2853115 chr11:133707908 C/T cg03690763 chr11:133734501 NA 0.37 6.21 0.32 1.64e-9 Childhood ear infection; CRC cis rs10463316 0.894 rs6864722 chr5:150752942 G/A cg03212797 chr5:150827313 SLC36A1 -0.5 -7.96 -0.4 2.86e-14 Metabolite levels (Pyroglutamine); CRC trans rs66573146 1.000 rs28384174 chr4:6961107 G/T cg07817883 chr1:32538562 TMEM39B 1.38 12.69 0.57 2.63e-30 Granulocyte percentage of myeloid white cells; CRC cis rs9467773 1.000 rs6932156 chr6:26571506 T/G cg09904177 chr6:26538194 HMGN4 0.86 14.82 0.63 2.06e-38 Intelligence (multi-trait analysis); CRC cis rs7177699 0.557 rs4380028 chr15:79111093 C/T cg15571903 chr15:79123663 NA -0.31 -6.08 -0.32 3.34e-9 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; CRC cis rs933688 0.941 rs11948056 chr5:90680468 A/C cg26981201 chr5:90679533 LOC100129716;ARRDC3 1.02 17.56 0.7 3.56e-49 Smoking behavior; CRC cis rs10256972 0.641 rs12702017 chr7:1129413 C/T cg03923535 chr7:1197113 ZFAND2A 0.65 9.32 0.46 1.74e-18 Longevity;Endometriosis; CRC cis rs13108904 0.870 rs12499546 chr4:1255194 C/T cg20092199 chr4:1342459 KIAA1530 0.34 5.9 0.31 8.88e-9 Obesity-related traits; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg03637622 chr5:179334771 TBC1D9B 0.45 6.5 0.34 2.92e-10 Intelligence (multi-trait analysis); CRC cis rs896854 0.654 rs2011566 chr8:95971921 G/A cg13393036 chr8:95962371 TP53INP1 -0.51 -8.71 -0.43 1.55e-16 Type 2 diabetes; CRC cis rs6933660 0.646 rs6911456 chr6:151778934 A/G cg14416726 chr6:151773293 C6orf211;RMND1 -0.72 -11.18 -0.52 7.99e-25 Menarche (age at onset); CRC cis rs4803480 0.935 rs1476769 chr19:42084277 C/G cg08478046 chr19:42093086 CEACAM21 -0.33 -5.88 -0.31 1.01e-8 Schizophrenia; CRC cis rs1559088 0.576 rs7251626 chr19:33578470 C/A cg27124370 chr19:33622961 WDR88 0.49 7.37 0.38 1.4e-12 Bone ultrasound measurement (broadband ultrasound attenuation); CRC cis rs2070488 0.965 rs3762791 chr3:38568828 T/C cg01465620 chr3:38496096 LOC100128640;ACVR2B -0.9 -16.62 -0.68 1.91e-45 Electrocardiographic conduction measures; CRC cis rs4900538 0.819 rs72698595 chr14:102863099 G/A cg18135206 chr14:102964638 TECPR2 -0.97 -17.74 -0.7 7.23e-50 Mean corpuscular volume;Mean corpuscular hemoglobin; CRC cis rs10876993 0.855 rs1689604 chr12:58048304 T/C cg18357645 chr12:58087776 OS9 0.56 7.71 0.39 1.48e-13 Celiac disease or Rheumatoid arthritis; CRC trans rs9825823 0.617 rs2083264 chr3:61074229 A/G cg00920043 chr1:11333412 UBIAD1 0.43 6.02 0.31 4.75e-9 Depressive symptom measurement or major depressive disorder; CRC cis rs17818399 0.749 rs35625984 chr2:46805908 A/G cg26688816 chr2:46740690 ATP6V1E2 -0.48 -6.35 -0.33 7.34e-10 Height; CRC cis rs1862618 0.754 rs252899 chr5:56188569 G/C cg12311346 chr5:56204834 C5orf35 -0.83 -10.44 -0.5 3.04e-22 Initial pursuit acceleration; CRC cis rs769267 0.965 rs1010207 chr19:19416045 T/C cg03709012 chr19:19516395 GATAD2A 0.7 10.72 0.51 3.35e-23 Tonsillectomy; CRC cis rs4841398 1.000 rs4841398 chr8:10462806 C/T cg27411982 chr8:10470053 RP1L1 -0.5 -6.26 -0.33 1.18e-9 Obesity-related traits; CRC cis rs10504229 0.728 rs72650867 chr8:58154912 C/T cg24829409 chr8:58192753 C8orf71 -0.58 -7.96 -0.4 2.86e-14 Developmental language disorder (linguistic errors); CRC cis rs477692 0.629 rs945231 chr10:131294827 A/G cg05714579 chr10:131428358 MGMT 0.51 7.2 0.37 4e-12 Response to temozolomide; CRC cis rs9400239 0.622 rs1268168 chr6:109008158 G/A cg11073813 chr6:109029018 NA -0.41 -6.46 -0.34 3.82e-10 Waist circumference;Body mass index;BMI (adjusted for smoking behaviour); CRC cis rs2032447 0.933 rs1540275 chr6:26036476 T/C cg26028573 chr6:26043587 HIST1H2BB 0.5 7.28 0.37 2.43e-12 Intelligence (multi-trait analysis); CRC cis rs6500395 1.000 rs9930199 chr16:48571263 A/G cg04672837 chr16:48644449 N4BP1 0.45 6.69 0.35 9.47e-11 Response to tocilizumab in rheumatoid arthritis; CRC cis rs2576037 0.583 rs10070 chr18:44388899 G/A cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.64 11.08 0.52 1.82e-24 Personality dimensions; CRC cis rs1707322 0.638 rs1707302 chr1:46600917 A/G cg06784218 chr1:46089804 CCDC17 -0.48 -7.8 -0.4 8.16e-14 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs7264396 0.790 rs2207889 chr20:34224898 A/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.62 -10.23 -0.49 1.68e-21 Total cholesterol levels; CRC trans rs2797160 1.000 rs926853 chr6:126021435 A/T cg05039488 chr6:79577232 IRAK1BP1 0.52 7.73 0.39 1.33e-13 Endometrial cancer; CRC cis rs10504229 0.683 rs34804288 chr8:58117570 C/A cg02290350 chr8:58132656 NA -0.58 -8.16 -0.41 7.29e-15 Developmental language disorder (linguistic errors); CRC cis rs10463316 0.817 rs7713109 chr5:150789284 A/G cg03212797 chr5:150827313 SLC36A1 -0.42 -6.59 -0.34 1.76e-10 Metabolite levels (Pyroglutamine); CRC cis rs6860806 0.507 rs272880 chr5:131670178 C/T cg11843238 chr5:131593191 PDLIM4 0.43 7.31 0.37 1.98e-12 Breast cancer; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg06802374 chr4:148653449 ARHGAP10 0.43 6.06 0.32 3.74e-9 Response to antipsychotic treatment; CRC cis rs7772486 0.875 rs9403765 chr6:146368041 C/T cg23711669 chr6:146136114 FBXO30 -0.61 -10.42 -0.5 3.79e-22 Lobe attachment (rater-scored or self-reported); CRC cis rs501120 0.584 rs12355852 chr10:44704280 G/T cg09554077 chr10:44749378 NA 0.67 7.47 0.38 7.27e-13 Coronary artery disease;Coronary heart disease; CRC cis rs4819052 0.679 rs4819053 chr21:46711357 C/T cg19498844 chr21:46707878 POFUT2;LOC642852 -0.64 -9.58 -0.47 2.47e-19 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs933688 0.938 rs10063683 chr5:90714595 G/A cg02339078 chr5:90679543 LOC100129716;ARRDC3 0.92 13.87 0.61 9.28e-35 Smoking behavior; CRC cis rs1580019 0.587 rs6951955 chr7:32548761 A/T cg07520158 chr7:32535189 LSM5;AVL9 0.55 8.08 0.41 1.25e-14 Cognitive ability; CRC cis rs2795502 0.630 rs873300 chr10:43537155 C/T cg20628663 chr10:43360327 NA 0.58 6.64 0.34 1.32e-10 Blood protein levels; CRC cis rs9389248 0.690 rs6569982 chr6:135256495 C/G cg24558204 chr6:135376177 HBS1L 0.51 7.47 0.38 7.41e-13 High light scatter reticulocyte percentage of red cells; CRC cis rs7914558 0.966 rs11191518 chr10:104782853 C/G cg04362960 chr10:104952993 NT5C2 0.6 9.07 0.45 1.13e-17 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs514406 0.505 rs146750 chr1:53183447 C/G cg24675658 chr1:53192096 ZYG11B -0.66 -9.96 -0.48 1.39e-20 Monocyte count; CRC cis rs17767392 0.829 rs56363446 chr14:71761577 A/G cg13720639 chr14:72061746 SIPA1L1 -0.53 -6.81 -0.35 4.7e-11 Mitral valve prolapse; CRC cis rs853679 0.517 rs9393884 chr6:28046789 A/G cg02631126 chr6:28058918 ZSCAN12L1 0.29 6.07 0.32 3.59e-9 Depression; CRC cis rs4588572 0.643 rs6861678 chr5:77764613 G/C cg11446398 chr5:77624930 NA 0.47 6.27 0.33 1.1e-9 Triglycerides; CRC cis rs4713118 0.629 rs203889 chr6:28021775 T/G cg18032046 chr6:28092343 ZSCAN16 -0.5 -6.41 -0.33 5.02e-10 Parkinson's disease; CRC cis rs7937682 1.000 rs11213973 chr11:111538903 A/T cg19812747 chr11:111475976 SIK2 -0.55 -9.25 -0.45 2.84e-18 Primary sclerosing cholangitis; CRC cis rs10791097 0.694 rs4936123 chr11:130740967 G/A cg12179176 chr11:130786555 SNX19 0.76 13.13 0.59 6.06e-32 Autism spectrum disorder or schizophrenia;Schizophrenia; CRC cis rs208520 1.000 rs12216109 chr6:66987488 C/G cg07460842 chr6:66804631 NA 0.92 11.13 0.52 1.2e-24 Exhaled nitric oxide output; CRC cis rs75422866 0.867 rs73104111 chr12:48067777 A/G cg14736327 chr12:48174669 SLC48A1 -0.79 -6.01 -0.31 4.92e-9 Pneumonia; CRC trans rs1864729 1.000 rs2853312 chr8:98281319 T/C cg08679828 chr8:102218111 ZNF706 -0.61 -7.47 -0.38 7.37e-13 Estradiol plasma levels (breast cancer); CRC cis rs12024301 0.557 rs12031255 chr1:183591537 T/C cg11505048 chr1:183622726 RGL1;APOBEC4 0.76 6.93 0.36 2.16e-11 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs61008539 0.893 rs11765528 chr7:861952 C/T cg00934597 chr7:893267 UNC84A -0.58 -7.91 -0.4 3.89e-14 Perceived unattractiveness to mosquitoes; CRC cis rs875971 0.830 rs778711 chr7:65851657 G/A cg12463550 chr7:65579703 CRCP 0.48 6.52 0.34 2.72e-10 Aortic root size; CRC cis rs12826942 0.959 rs12820881 chr12:42726978 G/A cg11827402 chr12:42719852 PPHLN1;ZCRB1 0.62 7.69 0.39 1.73e-13 Coronary artery disease; CRC cis rs2857891 0.697 rs1004754 chr11:6946248 T/C cg12728517 chr11:6947552 ZNF215 0.55 5.81 0.31 1.48e-8 Response to cytadine analogues (cytosine arabinoside); CRC cis rs9527 0.545 rs7894588 chr10:104756030 A/T cg15744005 chr10:104629667 AS3MT -0.3 -5.72 -0.3 2.41e-8 Arsenic metabolism; CRC cis rs7843479 0.601 rs4872204 chr8:21841396 T/C cg16476235 chr8:21771668 DOK2 0.38 6.54 0.34 2.37e-10 Mean corpuscular volume; CRC cis rs9903692 0.909 rs11079806 chr17:46142680 C/T cg21215337 chr17:46176117 CBX1 0.39 7.02 0.36 1.26e-11 Pulse pressure; CRC cis rs11190604 1.000 rs1106565 chr10:102211613 T/C cg16342193 chr10:102329863 NA -0.37 -6.17 -0.32 2.02e-9 Palmitoleic acid (16:1n-7) levels; CRC cis rs9443645 0.527 rs9350792 chr6:79587173 A/G cg09184832 chr6:79620586 NA -0.47 -8.21 -0.41 4.97e-15 Intelligence (multi-trait analysis); CRC cis rs477692 0.905 rs509041 chr10:131424948 A/G cg05714579 chr10:131428358 MGMT 0.61 8.82 0.44 6.62e-17 Response to temozolomide; CRC cis rs35110281 0.782 rs2329442 chr21:45041790 T/C cg01579765 chr21:45077557 HSF2BP -0.38 -7.31 -0.37 2.04e-12 Mean corpuscular volume; CRC cis rs6693567 0.565 rs10888578 chr1:150260993 A/G cg15654264 chr1:150340011 RPRD2 -0.39 -5.88 -0.31 1.02e-8 Migraine; CRC cis rs11031096 0.542 rs10835337 chr11:3958828 A/G cg18678763 chr11:4115507 RRM1 0.4 6.82 0.35 4.36e-11 Mean corpuscular volume;Mean corpuscular hemoglobin; CRC cis rs9611565 0.649 rs5758344 chr22:41817685 G/A cg06481639 chr22:41940642 POLR3H 0.52 5.7 0.3 2.61e-8 Vitiligo; CRC cis rs2084637 1.000 rs10892853 chr11:122390886 A/G cg21585512 chr11:122030076 LOC399959 -0.41 -7.5 -0.38 5.96e-13 Stroke; CRC cis rs7633770 0.786 rs6808214 chr3:46682746 T/C cg11219411 chr3:46661640 NA 0.53 8.47 0.42 8.51e-16 Coronary artery disease; CRC cis rs6504950 0.800 rs7208123 chr17:53006339 G/A cg26251398 chr17:52985966 TOM1L1 0.4 5.66 0.3 3.24e-8 Breast cancer; CRC cis rs2565722 0.825 rs2489929 chr6:161270781 C/T cg03159191 chr6:161285451 NA -0.48 -5.75 -0.3 2.04e-8 Blood protein levels; CRC cis rs4664293 0.609 rs12470879 chr2:160468627 T/C cg08347373 chr2:160653686 CD302 -0.39 -6.55 -0.34 2.16e-10 Monocyte percentage of white cells; CRC cis rs3785574 1.000 rs3785574 chr17:61763185 T/C cg22520471 chr17:61851767 DDX42;CCDC47 0.49 6.73 0.35 7.76e-11 Height; CRC cis rs780096 0.565 rs11681351 chr2:27743423 G/A cg02592271 chr2:27665507 KRTCAP3 -0.27 -5.95 -0.31 7e-9 Total body bone mineral density; CRC cis rs10504229 0.775 rs56082079 chr8:58163732 T/C cg02725872 chr8:58115012 NA -0.59 -9.12 -0.45 7.59e-18 Developmental language disorder (linguistic errors); CRC cis rs9311676 0.656 rs56232415 chr3:58394850 C/T cg06643156 chr3:58380774 PXK 0.41 6.33 0.33 7.82e-10 Systemic lupus erythematosus; CRC cis rs8180040 0.620 rs11720139 chr3:47036756 C/G cg02527881 chr3:46936655 PTH1R 0.34 5.92 0.31 7.97e-9 Colorectal cancer; CRC cis rs12926788 0.542 rs11862971 chr16:24767574 C/A cg02428538 chr16:24856791 SLC5A11 -0.56 -6.66 -0.34 1.18e-10 Ejection fraction in Tripanosoma cruzi seropositivity; CRC trans rs13046373 0.905 rs4816372 chr21:32077414 A/T cg10858369 chr11:6476139 TRIM3 -0.4 -6.29 -0.33 1e-9 HDL cholesterol; CRC cis rs9733 0.596 rs2867304 chr1:150630995 G/A cg18016565 chr1:150552671 MCL1 0.46 6.74 0.35 6.91e-11 Tonsillectomy; CRC cis rs7937682 0.601 rs2187388 chr11:111387116 C/T cg09085632 chr11:111637200 PPP2R1B 0.55 7.39 0.38 1.21e-12 Primary sclerosing cholangitis; CRC cis rs2832191 0.791 rs2832202 chr21:30501342 G/A cg24692254 chr21:30365293 RNF160 -0.68 -11.64 -0.54 1.85e-26 Dental caries; CRC cis rs754466 0.580 rs10824571 chr10:79531931 G/A cg17075019 chr10:79541650 NA -0.94 -17.21 -0.69 8.32e-48 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs637571 0.546 rs11227311 chr11:65585257 C/A cg04055107 chr11:65626734 MUS81;CFL1 -0.44 -6.0 -0.31 5.18e-9 Eosinophil percentage of white cells; CRC cis rs7621025 0.500 rs9845460 chr3:136587117 A/G cg15507776 chr3:136538369 TMEM22 0.44 6.73 0.35 7.55e-11 C-reactive protein levels or HDL-cholesterol levels (pleiotropy);Body mass index; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg02174006 chr10:86088279 FAM190B 0.45 6.24 0.33 1.38e-9 Response to antipsychotic treatment; CRC cis rs2617583 0.967 rs2550948 chr5:1450444 C/T cg07151155 chr5:1473589 LPCAT1 -0.43 -6.59 -0.34 1.7e-10 Breast cancer; CRC cis rs7773004 0.875 rs6456713 chr6:26325843 A/G cg13736514 chr6:26305472 NA -0.36 -6.17 -0.32 1.99e-9 Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for body mass index;Waist circumference adjusted for BMI in non-smokers;Waist circumference adjusted for BMI (adjusted for smoking behaviour); CRC cis rs8053891 0.502 rs34679758 chr16:71995427 A/G cg04254540 chr16:71951199 KIAA0174 -0.96 -9.7 -0.47 9.78e-20 Coronary artery disease; CRC cis rs972578 1.000 rs1569510 chr22:43359448 A/G cg01576275 chr22:43409880 NA 0.44 7.07 0.36 9.54e-12 Mean platelet volume; CRC cis rs11628318 0.853 rs7155171 chr14:103031845 C/T cg12046867 chr14:103022105 NA -0.82 -11.82 -0.55 4.2e-27 Platelet count; CRC cis rs12143943 0.966 rs898385 chr1:204579860 A/G cg17419461 chr1:204415978 PIK3C2B 0.4 6.38 0.33 6.16e-10 Cognitive performance; CRC cis rs6860806 0.507 rs635620 chr5:131720263 A/G cg22638593 chr5:131593259 PDLIM4 -0.39 -6.49 -0.34 3.13e-10 Breast cancer; CRC cis rs11214589 0.651 rs12360992 chr11:113262900 A/C cg14159747 chr11:113255604 NA 0.63 12.62 0.57 4.77e-30 Neuroticism; CRC trans rs61931739 0.517 rs7139189 chr12:34319757 T/C cg26384229 chr12:38710491 ALG10B 0.51 7.24 0.37 3.24e-12 Morning vs. evening chronotype; CRC cis rs2302190 0.882 rs9903173 chr17:56607358 C/T cg25885038 chr17:56607967 SEPT4 -0.49 -7.56 -0.38 3.99e-13 Vitamin D levels; CRC cis rs4555082 0.874 rs3000075 chr14:105713219 C/T cg18132624 chr14:105716052 BTBD6;BRF1 0.48 8.03 0.4 1.75e-14 Mean platelet volume;Platelet distribution width; CRC cis rs12681288 0.676 rs2701914 chr8:999935 C/T cg04851639 chr8:1020857 NA -0.4 -7.92 -0.4 3.64e-14 Schizophrenia; CRC cis rs6700896 0.931 rs4655585 chr1:66155627 T/C cg04111102 chr1:66153794 NA 0.33 5.78 0.3 1.74e-8 C-reactive protein;Mean corpuscular volume;Mean corpuscular hemoglobin; CRC cis rs425277 0.583 rs3107151 chr1:2051513 T/G cg24578937 chr1:2090814 PRKCZ -0.45 -8.2 -0.41 5.4e-15 Height; CRC cis rs1150688 1 rs1150688 chr6:28162780 T/C cg03623178 chr6:28175578 NA 0.67 10.21 0.49 1.89e-21 Autism spectrum disorder or schizophrenia; CRC cis rs6952808 1.000 rs10233560 chr7:1885415 T/C cg22963979 chr7:1858916 MAD1L1 -0.59 -9.4 -0.46 9.58e-19 Bipolar disorder and schizophrenia; CRC cis rs3785574 0.962 rs56295011 chr17:61850359 A/G cg25654072 chr17:61904446 PSMC5;FTSJ3 0.42 5.88 0.31 1.01e-8 Height; CRC cis rs7680126 0.500 rs4640669 chr4:10145733 A/G cg11266682 chr4:10021025 SLC2A9 0.41 6.25 0.33 1.3e-9 Urate levels in lean individuals;Urate levels in overweight individuals;Urate levels in obese individuals; CRC cis rs2882667 0.659 rs311595 chr5:138071872 T/C cg09476006 chr5:138032270 NA 0.58 10.33 0.49 7.58e-22 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs644148 0.704 rs2686761 chr19:44989752 T/C cg15540054 chr19:45004280 ZNF180 -0.54 -6.78 -0.35 5.44e-11 Personality dimensions; CRC cis rs8077889 1.000 rs2066725 chr17:41891473 A/G cg25876840 chr17:41920477 NA 0.51 7.8 0.4 8.25e-14 Triglycerides; CRC cis rs9914544 0.564 rs1859083 chr17:18843306 C/T cg26306683 chr17:18585705 ZNF286B -0.41 -6.47 -0.34 3.57e-10 Educational attainment (years of education); CRC cis rs7772486 0.875 rs2474356 chr6:146296798 G/A cg13319975 chr6:146136371 FBXO30 -0.39 -5.84 -0.31 1.27e-8 Lobe attachment (rater-scored or self-reported); CRC cis rs7772486 0.790 rs9399571 chr6:146282061 A/G cg23711669 chr6:146136114 FBXO30 -0.71 -12.41 -0.56 2.97e-29 Lobe attachment (rater-scored or self-reported); CRC cis rs1030268 0.577 rs13244007 chr7:133260825 A/G cg10665199 chr7:133106180 EXOC4 0.66 7.88 0.4 4.73e-14 Intelligence (multi-trait analysis); CRC cis rs477895 0.713 rs7952318 chr11:63961242 G/A cg05016508 chr11:63871570 FLRT1;MACROD1 0.51 6.66 0.34 1.15e-10 Mean platelet volume; CRC cis rs8072100 0.576 rs7216112 chr17:45406345 C/T cg25173405 chr17:45401733 C17orf57 0.52 8.17 0.41 6.91e-15 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg25589956 chr3:186545102 NA 0.36 6.31 0.33 8.76e-10 Obesity-related traits; CRC trans rs11722228 0.549 rs41268389 chr4:10099277 G/A cg26043149 chr18:55253948 FECH 1.14 17.46 0.69 9.11e-49 Gout;Urate levels;Serum uric acid levels; CRC cis rs7202877 0.610 rs3851735 chr16:75372092 A/G cg03315344 chr16:75512273 CHST6 0.55 6.42 0.33 4.74e-10 Type 2 diabetes;Type 1 diabetes; CRC cis rs1009181 0.585 rs2066295 chr6:26168903 A/G cg00631329 chr6:26305371 NA -0.41 -6.16 -0.32 2.14e-9 Childhood ear infection; CRC cis rs317689 0.819 rs317667 chr12:69703754 G/T cg20891283 chr12:69753455 YEATS4 0.47 6.07 0.32 3.48e-9 Response to diuretic therapy; CRC cis rs10256972 0.591 rs6950319 chr7:1161324 A/G cg18765753 chr7:1198926 ZFAND2A -0.39 -6.72 -0.35 8.12e-11 Longevity;Endometriosis; CRC cis rs12048904 0.533 rs1590580 chr1:101292668 A/G cg00063077 chr1:101360652 SLC30A7;EXTL2 0.76 10.95 0.52 5.37e-24 Multiple sclerosis; CRC cis rs921968 0.643 rs2178019 chr2:219316303 G/A cg02176678 chr2:219576539 TTLL4 0.49 8.04 0.41 1.65e-14 Mean corpuscular hemoglobin concentration; CRC cis rs2882667 0.858 rs66839813 chr5:138442322 A/T cg04439458 chr5:138467593 SIL1 -0.35 -5.98 -0.31 5.86e-9 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs13256369 1.000 rs12550762 chr8:8576535 T/A cg18904891 chr8:8559673 CLDN23 0.53 7.45 0.38 8.19e-13 Obesity-related traits; CRC cis rs2153535 0.580 rs6914276 chr6:8450435 A/T cg21535247 chr6:8435926 SLC35B3 -0.48 -7.28 -0.37 2.4e-12 Motion sickness; CRC cis rs4665809 0.556 rs10221814 chr2:26442759 C/T cg04944784 chr2:26401820 FAM59B -0.87 -11.85 -0.55 3.24e-27 Gut microbiome composition (summer); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg11876132 chr22:25348250 NA 0.43 6.15 0.32 2.23e-9 Response to antipsychotic treatment; CRC trans rs61931739 0.500 rs6488215 chr12:34434803 A/T cg13010199 chr12:38710504 ALG10B 0.45 6.46 0.34 3.76e-10 Morning vs. evening chronotype; CRC trans rs10983614 1.000 rs7867776 chr9:120072627 A/G cg26348180 chr3:193852754 HES1 0.46 6.22 0.32 1.53e-9 Survival in pancreatic cancer; CRC cis rs9292777 0.966 rs1373692 chr5:40431183 A/C cg09067459 chr5:40385259 NA 0.51 8.91 0.44 3.5e-17 Crohn's disease;Multiple sclerosis; CRC cis rs13108904 0.870 rs4974541 chr4:1244037 A/G cg20092199 chr4:1342459 KIAA1530 0.32 5.72 0.3 2.38e-8 Obesity-related traits; CRC cis rs9420 0.961 rs12807250 chr11:57600285 C/T cg23127183 chr11:57508653 C11orf31 -0.53 -7.14 -0.37 6.02e-12 Schizophrenia; CRC cis rs6942756 0.806 rs7788327 chr7:128986519 C/T cg02491457 chr7:128862824 NA -0.64 -8.67 -0.43 1.98e-16 White matter hyperintensity burden; CRC cis rs7666738 0.830 rs17027198 chr4:98991085 G/C cg05340658 chr4:99064831 C4orf37 0.62 9.6 0.47 2.15e-19 Colonoscopy-negative controls vs population controls; CRC cis rs9291683 0.618 rs13137343 chr4:10043028 C/A cg00071950 chr4:10020882 SLC2A9 0.67 12.67 0.57 3.14e-30 Bone mineral density; CRC cis rs10752881 1.000 rs10797807 chr1:182978873 T/C ch.1.3577855R chr1:183094577 LAMC1 0.87 15.17 0.64 8.98e-40 Colorectal cancer; CRC cis rs2011503 1.000 rs8105642 chr19:19558468 G/A cg11584989 chr19:19387371 SF4 0.53 5.96 0.31 6.67e-9 Bipolar disorder; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg05647660 chr4:76439704 RCHY1;THAP6 0.47 6.61 0.34 1.56e-10 Response to antipsychotic treatment; CRC cis rs9399135 0.816 rs4134030 chr6:135354094 G/T cg24558204 chr6:135376177 HBS1L 0.51 8.09 0.41 1.19e-14 Red blood cell count; CRC cis rs694739 0.536 rs671976 chr11:64046029 G/A cg05555928 chr11:63887634 MACROD1 -0.39 -6.6 -0.34 1.64e-10 Alopecia areata;Crohn's disease;Psoriasis vulgaris; CRC cis rs704795 0.775 rs4665975 chr2:27626017 A/T cg12648201 chr2:27665141 KRTCAP3 -0.3 -5.62 -0.3 4.11e-8 Menopause (age at onset); CRC cis rs10504229 0.639 rs56825757 chr8:58106469 A/G cg02290350 chr8:58132656 NA -0.59 -8.02 -0.4 1.88e-14 Developmental language disorder (linguistic errors); CRC cis rs7945718 0.621 rs7931351 chr11:12692162 A/T cg25843174 chr11:12811716 TEAD1 0.41 7.55 0.38 4.33e-13 Educational attainment (years of education); CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg06713199 chr3:28390809 AZI2 -0.52 -6.3 -0.33 9.77e-10 Diisocyanate-induced asthma; CRC cis rs172166 0.769 rs149965 chr6:28018689 T/A cg12273811 chr6:28175739 NA 0.55 8.0 0.4 2.2e-14 Cardiac Troponin-T levels; CRC cis rs2228479 1.000 rs2228479 chr16:89985940 G/A cg12064134 chr16:90016061 DEF8 -0.65 -5.84 -0.31 1.22e-8 Skin colour saturation; CRC cis rs8078723 1.000 rs4795415 chr17:38157995 C/T cg17344932 chr17:38183730 MED24;SNORD124 -0.45 -6.9 -0.36 2.73e-11 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); CRC cis rs67311347 1.000 rs7628796 chr3:40507332 G/A cg24209194 chr3:40518798 ZNF619 -0.43 -6.3 -0.33 9.56e-10 Renal cell carcinoma; CRC cis rs853679 0.517 rs9393891 chr6:28079160 C/T cg02631126 chr6:28058918 ZSCAN12L1 0.29 5.87 0.31 1.05e-8 Depression; CRC cis rs4808199 1.000 rs60321073 chr19:19499598 A/G cg03709012 chr19:19516395 GATAD2A 1.03 12.5 0.57 1.3e-29 Nonalcoholic fatty liver disease; CRC cis rs601339 1.000 rs601339 chr12:123174743 A/G cg22192744 chr12:123187474 GPR109A -0.4 -5.67 -0.3 3.16e-8 Adiponectin levels; CRC cis rs11098499 0.909 rs28793658 chr4:120307214 A/C cg09307838 chr4:120376055 NA 0.71 10.95 0.52 5.47e-24 Corneal astigmatism; CRC cis rs2742417 0.967 rs1969625 chr3:45734975 A/G cg04837898 chr3:45731254 SACM1L -0.34 -5.63 -0.3 3.95e-8 Response to anti-depressant treatment in major depressive disorder; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg05719672 chr15:91446576 MAN2A2 0.37 6.03 0.32 4.5e-9 Liver disease severity in Alagille syndrome; CRC cis rs847649 0.731 rs12666317 chr7:102704135 C/T cg18108683 chr7:102477205 FBXL13 0.52 8.22 0.41 4.89e-15 Morning vs. evening chronotype; CRC cis rs9911578 1.000 rs999431 chr17:56854441 A/G cg12560992 chr17:57184187 TRIM37 0.9 16.4 0.67 1.34e-44 Intelligence (multi-trait analysis); CRC cis rs4268898 0.552 rs35331966 chr2:24367828 C/T cg06627628 chr2:24431161 ITSN2 0.45 6.87 0.35 3.14e-11 Asthma; CRC cis rs1178968 0.688 rs6951676 chr7:72753243 C/T cg25889504 chr7:72793014 NA 0.53 6.04 0.32 4.16e-9 Triglyceride levels; CRC trans rs2243480 0.901 rs778732 chr7:65822360 C/T cg10756647 chr7:56101905 PSPH 0.77 7.78 0.39 9.16e-14 Diabetic kidney disease; CRC cis rs7666738 0.753 rs11097594 chr4:98944486 A/G cg05340658 chr4:99064831 C4orf37 0.61 9.54 0.47 3.45e-19 Colonoscopy-negative controls vs population controls; CRC cis rs28386778 0.897 rs8069969 chr17:61822223 T/G cg00280220 chr17:61926910 NA 0.33 5.64 0.3 3.66e-8 Prudent dietary pattern; CRC cis rs1153858 1.000 rs8032904 chr15:45651309 C/T cg14582100 chr15:45693742 SPATA5L1 0.29 6.11 0.32 2.89e-9 Homoarginine levels; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg21824114 chr17:41322603 NBR1 0.4 6.09 0.32 3.18e-9 Liver disease severity in Alagille syndrome; CRC cis rs6502050 0.635 rs9889327 chr17:80087839 G/A cg13198984 chr17:80129470 CCDC57 0.47 8.45 0.42 9.24e-16 Life satisfaction; CRC cis rs9435341 0.965 rs6669831 chr1:107608607 G/A cg09367891 chr1:107599246 PRMT6 -0.65 -10.18 -0.49 2.41e-21 Facial morphology (factor 21, depth of nasal alae); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg09518715 chr2:238384359 NA 0.41 6.0 0.31 5.13e-9 Intelligence (multi-trait analysis); CRC cis rs12188164 0.686 rs72711367 chr5:418494 A/G cg17553881 chr5:443987 EXOC3;C5orf55 -0.36 -7.35 -0.38 1.55e-12 Cystic fibrosis severity; CRC cis rs7412746 0.658 rs17660092 chr1:150797748 T/C cg18016565 chr1:150552671 MCL1 0.44 6.13 0.32 2.54e-9 Melanoma; CRC cis rs4862750 0.914 rs1346127 chr4:187876389 C/T cg22105103 chr4:187893119 NA -0.64 -11.72 -0.54 9.3e-27 Lobe attachment (rater-scored or self-reported); CRC cis rs149866169 1 rs149866169 chr6:27441723 T/A cg19041857 chr6:27730383 NA -0.79 -6.98 -0.36 1.59e-11 Neuroticism (multi-trait analysis);Lung cancer in ever smokers;Subjective well-being (multi-trait analysis);Lung cancer;Squamous cell lung carcinoma; CRC cis rs2953174 0.744 rs2975748 chr2:241518989 A/G cg07929629 chr2:241523174 NA 0.53 6.43 0.33 4.39e-10 Bipolar disorder; CRC cis rs3785574 0.962 rs2665835 chr17:61903258 C/T cg06601766 chr17:61851465 DDX42;CCDC47 0.6 8.45 0.42 9.3e-16 Height; CRC cis rs10864907 0.614 rs12468164 chr2:113712783 C/T cg06156847 chr2:113672199 IL1F7 0.43 6.47 0.34 3.46e-10 Pulmonary function; CRC cis rs9462846 0.845 rs9471964 chr6:42885664 C/A cg10862848 chr6:42927986 GNMT -0.27 -5.6 -0.3 4.42e-8 Blood protein levels; CRC cis rs1555322 0.530 rs2275275 chr20:33872311 G/C cg13662093 chr20:33865505 NA 0.41 5.77 0.3 1.87e-8 Attention deficit hyperactivity disorder; CRC cis rs5753618 0.583 rs5749270 chr22:31812853 C/T cg22777020 chr22:31556080 RNF185 0.53 6.25 0.33 1.25e-9 Colorectal cancer; CRC cis rs7258465 1.000 rs10409483 chr19:18590223 C/G cg06953865 chr19:18549723 ISYNA1 -0.38 -5.8 -0.3 1.55e-8 Breast cancer; CRC cis rs6496667 1.000 rs75444304 chr15:90894246 C/T cg04176472 chr15:90893244 GABARAPL3 0.53 8.15 0.41 7.96e-15 Rheumatoid arthritis; CRC cis rs4722166 0.598 rs35658589 chr7:22800435 C/A cg05472934 chr7:22766657 IL6 0.63 10.36 0.5 5.88e-22 Lung cancer; CRC cis rs6840360 0.593 rs11723227 chr4:152689717 G/A cg09659197 chr4:152720779 NA 0.39 8.18 0.41 6.42e-15 Intelligence (multi-trait analysis); CRC cis rs2898681 0.581 rs936690 chr4:53691035 A/G cg00338735 chr4:53728038 RASL11B 0.38 5.83 0.31 1.29e-8 Optic nerve measurement (cup area); CRC cis rs9611519 0.929 rs2064560 chr22:41530040 A/G cg03806693 chr22:41940476 POLR3H -0.54 -6.69 -0.35 9.48e-11 Neuroticism; CRC cis rs7586879 0.558 rs6718510 chr2:25122323 A/C cg22495460 chr2:25135724 ADCY3 -0.87 -17.19 -0.69 1.03e-47 Body mass index; CRC cis rs9491140 1.000 rs12204812 chr6:124681503 C/A cg22366943 chr6:124882293 NKAIN2 0.35 5.8 0.3 1.6e-8 Neuroticism; CRC cis rs9611565 0.512 rs5758464 chr22:42171300 A/G cg03806693 chr22:41940476 POLR3H 0.99 10.53 0.5 1.51e-22 Vitiligo; CRC cis rs9787249 0.957 rs56064244 chr1:40213890 C/T cg19912559 chr1:40204330 PPIE 0.52 7.68 0.39 1.82e-13 Blood protein levels; CRC cis rs2811415 0.597 rs11711138 chr3:127762761 T/A cg13719885 chr3:127795394 NA -0.37 -5.67 -0.3 3.19e-8 Lung function (FEV1/FVC); CRC trans rs6557786 0.636 rs17052934 chr8:24840319 A/C cg25475538 chr8:22414555 SORBS3 0.31 6.05 0.32 3.89e-9 Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 2 peripheral neuropathy); CRC cis rs7264396 0.511 rs2425102 chr20:34312303 G/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.49 -6.83 -0.35 4.15e-11 Total cholesterol levels; CRC trans rs951252 0.504 rs11734405 chr4:146081096 C/T cg25816545 chr2:131513066 FAM123C 0.43 6.22 0.32 1.52e-9 Hip circumference; CRC cis rs57221529 0.713 rs56328416 chr5:591138 G/A cg09021430 chr5:549028 NA -0.69 -7.62 -0.39 2.8e-13 Lung disease severity in cystic fibrosis; CRC cis rs7247513 0.797 rs3815914 chr19:12760664 T/C cg01871581 chr19:12707946 ZNF490 -0.69 -10.78 -0.51 2.16e-23 Bipolar disorder; CRC cis rs897984 0.609 rs732172 chr16:31050033 C/T cg00531865 chr16:30841666 NA -0.42 -5.98 -0.31 5.87e-9 Dementia with Lewy bodies; CRC cis rs10504229 1.000 rs56255635 chr8:58178264 T/C cg02290350 chr8:58132656 NA -0.42 -5.96 -0.31 6.62e-9 Developmental language disorder (linguistic errors); CRC cis rs2160860 0.965 rs2729456 chr8:39819808 T/G cg11363097 chr8:39792086 IDO2 -0.37 -5.98 -0.31 5.96e-9 Blood metabolite levels; CRC cis rs6951245 1.000 rs78523927 chr7:1089458 T/C cg18402987 chr7:1209562 NA 0.64 6.67 0.35 1.05e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs4891159 0.790 rs72975925 chr18:74143902 G/A cg24786174 chr18:74118243 ZNF516 -0.85 -14.35 -0.62 1.34e-36 Longevity; CRC cis rs7043114 0.525 rs7863406 chr9:95053381 T/C cg14631576 chr9:95140430 CENPP -0.3 -5.76 -0.3 1.92e-8 Height; CRC cis rs2153535 0.580 rs7763190 chr6:8484197 G/A cg21535247 chr6:8435926 SLC35B3 0.5 7.51 0.38 5.54e-13 Motion sickness; CRC cis rs9291683 0.530 rs73227883 chr4:9979279 T/C cg00071950 chr4:10020882 SLC2A9 0.63 11.48 0.53 7.16e-26 Bone mineral density; CRC cis rs9322193 0.961 rs2064520 chr6:149924786 A/T cg00933542 chr6:150070202 PCMT1 0.29 6.04 0.32 4.14e-9 Lung cancer; CRC cis rs4268898 0.608 rs72793980 chr2:24428859 T/C cg06627628 chr2:24431161 ITSN2 -0.67 -9.14 -0.45 6.42e-18 Asthma; CRC cis rs7493 0.755 rs17166859 chr7:94995519 T/C cg19678392 chr7:94953810 PON1 -0.52 -6.59 -0.34 1.77e-10 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs863345 0.604 rs950260 chr1:158491520 G/A cg12129480 chr1:158549410 OR10X1 -0.3 -6.25 -0.33 1.25e-9 Pneumococcal bacteremia; CRC cis rs853679 1.000 rs9986596 chr6:28219661 G/A cg03623178 chr6:28175578 NA 0.74 7.23 0.37 3.38e-12 Depression; CRC cis rs7772486 0.790 rs3923579 chr6:146230232 C/G cg23711669 chr6:146136114 FBXO30 -0.72 -12.75 -0.58 1.54e-30 Lobe attachment (rater-scored or self-reported); CRC cis rs10504073 0.584 rs72641612 chr8:49947986 C/T cg00325661 chr8:49890786 NA 0.6 10.83 0.51 1.38e-23 Blood metabolite ratios; CRC cis rs1209950 0.536 rs464476 chr21:40225441 C/T cg02119577 chr21:40195074 ETS2 -0.37 -5.97 -0.31 6.09e-9 Non-small cell lung cancer (survival); CRC cis rs6831352 0.760 rs2602859 chr4:100030583 G/A cg13256891 chr4:100009986 ADH5 0.63 8.54 0.43 4.99e-16 Alcohol dependence; CRC cis rs1129187 0.967 rs11752813 chr6:42928017 C/G cg10862848 chr6:42927986 GNMT -0.37 -8.67 -0.43 2.04e-16 Alzheimer's disease in APOE e4+ carriers; CRC cis rs9322193 0.886 rs9718079 chr6:149967083 T/C cg13206674 chr6:150067644 NUP43 0.66 9.78 0.47 5.47e-20 Lung cancer; CRC cis rs4481887 0.861 rs4497248 chr1:248450525 T/C cg00666640 chr1:248458726 OR2T12 0.55 9.72 0.47 8.37e-20 Common traits (Other); CRC cis rs1552244 1.000 rs56270432 chr3:10087517 G/C cg08888203 chr3:10149979 C3orf24 0.7 9.84 0.48 3.31e-20 Alzheimer's disease; CRC cis rs11971779 0.590 rs4732374 chr7:139091453 G/C cg23387468 chr7:139079360 LUC7L2 0.41 7.04 0.36 1.14e-11 Diisocyanate-induced asthma; CRC cis rs9491140 0.539 rs10872284 chr6:124685928 G/A cg19267163 chr6:125004984 NKAIN2 0.44 6.02 0.32 4.65e-9 Neuroticism; CRC cis rs861020 0.606 rs627459 chr1:210004682 C/G cg05527609 chr1:210001259 C1orf107 0.77 10.68 0.51 4.51e-23 Orofacial clefts; CRC cis rs6748734 1.000 rs4675863 chr2:241830763 A/T cg04034577 chr2:241836375 C2orf54 -0.42 -8.82 -0.44 6.9e-17 Urinary metabolites; CRC cis rs8060686 0.844 rs7196076 chr16:67887494 T/A cg19582491 chr16:67682965 RLTPR -0.52 -5.88 -0.31 9.94e-9 HDL cholesterol;Metabolic syndrome; CRC cis rs832540 0.593 rs252912 chr5:56195792 C/T cg12311346 chr5:56204834 C5orf35 -0.54 -8.11 -0.41 1.03e-14 Coronary artery disease; CRC cis rs58688157 0.705 rs12419618 chr11:611531 G/A cg16486109 chr11:613632 IRF7 0.73 12.29 0.56 8.24e-29 Systemic lupus erythematosus; CRC cis rs10504229 0.683 rs16921831 chr8:58111142 G/A cg05313129 chr8:58192883 C8orf71 -0.42 -5.85 -0.31 1.16e-8 Developmental language disorder (linguistic errors); CRC cis rs6424115 0.965 rs2502979 chr1:24149315 C/A cg10978503 chr1:24200527 CNR2 0.49 8.75 0.43 1.12e-16 Immature fraction of reticulocytes; CRC trans rs11098499 0.863 rs11947234 chr4:120474859 A/G cg25214090 chr10:38739885 LOC399744 0.67 10.42 0.5 3.6e-22 Corneal astigmatism; CRC cis rs2408955 0.521 rs10875753 chr12:48557141 C/T cg24011408 chr12:48396354 COL2A1 0.44 6.49 0.34 3.16e-10 Glycated hemoglobin levels; CRC cis rs7119 0.634 rs2667782 chr15:77862296 A/C cg10437265 chr15:77819839 NA -0.5 -8.34 -0.42 2.06e-15 Type 2 diabetes; CRC cis rs3772130 0.962 rs11715951 chr3:121522968 T/C cg20356878 chr3:121714668 ILDR1 0.51 8.04 0.41 1.68e-14 Cognitive performance; CRC cis rs7615952 0.599 rs6803160 chr3:125709554 G/T cg15145296 chr3:125709740 NA -0.56 -6.7 -0.35 9e-11 Blood pressure (smoking interaction); CRC cis rs6461049 0.608 rs3800923 chr7:2184673 A/G cg02951883 chr7:2050386 MAD1L1 -0.51 -8.21 -0.41 5.13e-15 Schizophrenia; CRC cis rs3026101 0.578 rs1806238 chr17:5295502 C/T cg25236894 chr17:5323110 RPAIN;NUP88 0.42 6.84 0.35 3.98e-11 Body mass index; CRC cis rs34779708 0.966 rs17591163 chr10:35465279 G/C cg03585969 chr10:35415529 CREM 0.66 8.82 0.44 7e-17 Inflammatory bowel disease;Crohn's disease; CRC cis rs1065852 0.503 rs9620006 chr22:42399547 T/A cg22189786 chr22:42395067 WBP2NL 0.43 6.15 0.32 2.28e-9 Response to serotonin reuptake inhibitors in major depressive disorder (plasma drug and metabolite levels); CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg24869535 chr4:106816548 NPNT -0.41 -6.44 -0.33 4.15e-10 Myopia (pathological); CRC trans rs12478296 0.792 rs3924263 chr2:243005167 A/C cg06834434 chr14:75079333 LTBP2 0.55 6.62 0.34 1.47e-10 Obesity-related traits; CRC cis rs4689592 0.503 rs4689064 chr4:7055603 A/G cg19539972 chr4:7069911 GRPEL1 -0.84 -9.61 -0.47 1.95e-19 Monocyte percentage of white cells; CRC trans rs360798 0.512 rs4461246 chr2:63027671 C/T cg05376469 chr2:102649931 NA 0.37 6.17 0.32 2.05e-9 Coronary artery disease; CRC cis rs9467711 0.606 rs1978 chr6:26377573 A/T cg14345882 chr6:26364793 BTN3A2 0.71 5.87 0.31 1.07e-8 Autism spectrum disorder or schizophrenia; CRC cis rs2645694 0.626 rs2645705 chr4:77830434 G/A cg10057126 chr4:77819792 ANKRD56 0.34 5.7 0.3 2.64e-8 Emphysema distribution in smoking; CRC cis rs7605827 0.930 rs4668448 chr2:15521740 T/C cg19274914 chr2:15703543 NA 0.39 5.87 0.31 1.05e-8 Educational attainment (years of education); CRC trans rs1607741 1.000 rs10012922 chr4:72712036 G/A cg06437464 chr6:127441704 RSPO3 0.29 6.16 0.32 2.06e-9 Vitamin D levels; CRC cis rs6684514 1.000 rs12038203 chr1:156248265 C/T cg16558208 chr1:156270281 VHLL 0.59 9.2 0.45 4.08e-18 Mean corpuscular hemoglobin concentration;Glycated hemoglobin levels; CRC cis rs1882538 0.538 rs9649587 chr7:133104569 A/C cg10665199 chr7:133106180 EXOC4 0.69 10.95 0.52 5.3e-24 Intelligence (multi-trait analysis); CRC cis rs782590 0.774 rs2627773 chr2:55900459 A/G cg18811423 chr2:55921094 PNPT1 0.85 16.23 0.67 6.04e-44 Metabolic syndrome; CRC cis rs4654899 0.897 rs710311 chr1:21062001 T/C cg02927042 chr1:21476669 EIF4G3 -0.42 -6.73 -0.35 7.74e-11 Superior frontal gyrus grey matter volume; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg19472303 chr3:25705836 TOP2B -0.4 -6.15 -0.32 2.25e-9 Myopia (pathological); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg13014709 chr12:58148389 MARCH9 0.42 6.52 0.34 2.68e-10 Response to antipsychotic treatment; CRC cis rs7618915 0.571 rs1961958 chr3:52585990 A/G cg10802521 chr3:52805072 NEK4 -0.59 -9.08 -0.45 1.02e-17 Bipolar disorder; CRC cis rs1552244 1.000 rs17032414 chr3:10158302 C/G cg00166722 chr3:10149974 C3orf24 0.61 8.42 0.42 1.16e-15 Alzheimer's disease; CRC cis rs3820928 1.000 rs10193316 chr2:227777650 A/G cg11843606 chr2:227700838 RHBDD1 -0.4 -5.94 -0.31 7.15e-9 Pulmonary function; CRC trans rs7618501 0.602 rs2240327 chr3:50113034 C/T cg21665057 chr3:196295764 WDR53;FBXO45 0.61 9.66 0.47 1.31e-19 Intelligence (multi-trait analysis); CRC cis rs6582630 0.623 rs12299293 chr12:38436288 G/A cg26384229 chr12:38710491 ALG10B -0.52 -7.51 -0.38 5.69e-13 Drug-induced liver injury (flucloxacillin); CRC cis rs11191205 0.686 rs75299772 chr10:103418987 G/A cg15320455 chr10:103880129 LDB1 0.57 6.49 0.34 3.23e-10 Intelligence (multi-trait analysis); CRC cis rs8031584 0.541 rs2959037 chr15:31218164 T/C cg08109568 chr15:31115862 NA 0.4 6.6 0.34 1.64e-10 Huntington's disease progression; CRC cis rs8018808 0.935 rs2242619 chr14:77895119 C/T cg20045696 chr14:77926864 AHSA1 -0.36 -5.61 -0.3 4.27e-8 Myeloid white cell count; CRC cis rs636291 0.517 rs673254 chr1:10550352 C/T cg17425144 chr1:10567563 PEX14 0.53 12.12 0.56 3.34e-28 Prostate cancer; CRC cis rs727505 0.789 rs66756015 chr7:124740641 C/A cg23710748 chr7:124431027 NA -0.72 -12.07 -0.55 5.03e-28 Lewy body disease; CRC trans rs12458462 0.859 rs2242177 chr18:77477379 G/A cg09220050 chr20:48770642 TMEM189;TMEM189-UBE2V1 -0.48 -7.12 -0.37 6.86e-12 Monocyte count; CRC trans rs1656966 1.000 rs1656966 chr3:186466252 C/T cg11178574 chr11:561340 RASSF7;C11orf35 0.42 6.4 0.33 5.43e-10 Myopia (pathological); CRC cis rs10504229 0.815 rs75577263 chr8:58188434 A/G cg02290350 chr8:58132656 NA -0.42 -5.96 -0.31 6.62e-9 Developmental language disorder (linguistic errors); CRC trans rs875971 0.545 rs11770063 chr7:65783016 G/A cg02869306 chr7:64672164 INTS4L1 -0.44 -6.47 -0.34 3.54e-10 Aortic root size; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg07545948 chr6:12012569 HIVEP1 0.39 6.21 0.32 1.58e-9 Liver disease severity in Alagille syndrome; CRC cis rs644799 1.000 rs525404 chr11:95566520 A/G cg03916912 chr11:95522834 CEP57;FAM76B 0.96 18.35 0.71 2.69e-52 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg11855759 chr17:9548802 USP43 -0.44 -6.53 -0.34 2.48e-10 Myopia (pathological); CRC cis rs847649 1.000 rs13233521 chr7:102593794 C/T cg18108683 chr7:102477205 FBXL13 0.56 8.98 0.44 2.1e-17 Morning vs. evening chronotype; CRC cis rs4713118 0.869 rs9393851 chr6:27699581 A/T cg03623178 chr6:28175578 NA 0.66 9.34 0.46 1.46e-18 Parkinson's disease; CRC cis rs9287719 0.781 rs12472807 chr2:10781605 G/A cg00105475 chr2:10696890 NA 0.44 7.0 0.36 1.45e-11 Prostate cancer; CRC cis rs236352 0.576 rs6914008 chr6:36853037 T/A cg10099585 chr6:36853529 C6orf89 -0.44 -6.2 -0.32 1.67e-9 Heart rate; CRC cis rs9292777 0.720 rs4957288 chr5:40423840 C/A cg09067459 chr5:40385259 NA -0.55 -8.93 -0.44 3.12e-17 Crohn's disease;Multiple sclerosis; CRC cis rs17270561 0.636 rs6923367 chr6:25745852 A/T cg16482183 chr6:26056742 HIST1H1C 0.81 10.22 0.49 1.73e-21 Iron status biomarkers; CRC cis rs2991971 0.716 rs7532573 chr1:45915892 A/T cg24296786 chr1:45957014 TESK2 -0.49 -7.41 -0.38 1.05e-12 High light scatter reticulocyte count; CRC trans rs2303319 0.504 rs1449641 chr2:162619567 T/C cg04551154 chr10:95462393 C10orf4 -0.74 -6.34 -0.33 7.76e-10 Cognitive function; CRC cis rs798554 0.731 rs2283779 chr7:2815140 G/A cg19717773 chr7:2847554 GNA12 -0.45 -7.26 -0.37 2.87e-12 Height; CRC cis rs2949837 0.581 rs1543270 chr7:46006323 C/T cg04796162 chr7:45961102 IGFBP3 0.4 6.8 0.35 4.89e-11 Sitting height ratio; CRC cis rs9381040 0.610 rs2268195 chr6:41024340 G/A cg25110423 chr6:41068646 NFYA;LOC221442 -0.38 -5.77 -0.3 1.79e-8 Alzheimer's disease (late onset); CRC cis rs172166 0.516 rs2622322 chr6:28117443 C/G cg21251018 chr6:28226885 NKAPL 0.57 10.06 0.49 6.22e-21 Cardiac Troponin-T levels; CRC cis rs17023223 0.537 rs2794312 chr1:119591046 C/T cg05756136 chr1:119680316 WARS2 -0.47 -6.29 -0.33 1.01e-9 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for BMI in active individuals; CRC cis rs6540559 1.000 rs6659367 chr1:209982408 G/T cg23283495 chr1:209979779 IRF6 0.42 6.93 0.36 2.22e-11 Cleft lip with or without cleft palate; CRC cis rs9368481 0.761 rs4358615 chr6:26998567 A/G cg12292205 chr6:26970375 C6orf41 0.67 11.22 0.53 6.14e-25 Autism spectrum disorder or schizophrenia; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg25097676 chr10:99051975 ARHGAP19 0.44 6.39 0.33 5.71e-10 Response to antipsychotic treatment; CRC cis rs2404602 0.716 rs1946650 chr15:76848463 T/C cg22467129 chr15:76604101 ETFA -0.43 -7.35 -0.38 1.54e-12 Blood metabolite levels; CRC cis rs875971 1.000 rs2036264 chr7:65799904 G/A cg12463550 chr7:65579703 CRCP -0.5 -7.21 -0.37 3.91e-12 Aortic root size; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg01174859 chr7:128379317 CALU -0.44 -6.61 -0.34 1.56e-10 Myopia (pathological); CRC cis rs3823572 0.504 rs2971977 chr7:133648347 C/G cg03336402 chr7:133662267 EXOC4 -0.66 -10.39 -0.5 4.84e-22 Intelligence (multi-trait analysis); CRC cis rs7927771 0.507 rs12366244 chr11:47882130 C/A cg20307385 chr11:47447363 PSMC3 0.45 6.64 0.34 1.33e-10 Subjective well-being; CRC cis rs10504229 0.679 rs17193048 chr8:58055392 G/A cg21724239 chr8:58056113 NA 0.72 8.73 0.43 1.31e-16 Developmental language disorder (linguistic errors); CRC trans rs459571 1.000 rs2810489 chr9:136922700 C/T cg10765909 chr12:53715428 AAAS -0.48 -6.01 -0.31 4.93e-9 Platelet distribution width; CRC cis rs10504229 0.639 rs16921812 chr8:58106737 C/T cg04204079 chr8:58130323 NA -0.46 -5.79 -0.3 1.67e-8 Developmental language disorder (linguistic errors); CRC cis rs7959452 0.527 rs4761157 chr12:69780907 A/G cg20891283 chr12:69753455 YEATS4 0.91 17.31 0.69 3.38e-48 Blood protein levels; CRC cis rs6500395 1.000 rs7187513 chr16:48591638 T/C cg04672837 chr16:48644449 N4BP1 0.44 6.5 0.34 2.95e-10 Response to tocilizumab in rheumatoid arthritis; CRC cis rs4862750 0.832 rs6836426 chr4:187897837 T/G cg03452623 chr4:187889614 NA -0.92 -21.7 -0.77 1.99e-65 Lobe attachment (rater-scored or self-reported); CRC cis rs7493 1.000 rs2286232 chr7:95039445 C/T cg17330251 chr7:94953956 PON1 -0.56 -7.4 -0.38 1.17e-12 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs7762018 0.607 rs79897010 chr6:170042874 C/G cg24289452 chr6:170231220 NA -0.94 -7.59 -0.39 3.43e-13 Thiazide-induced adverse metabolic effects in hypertensive patients; CRC cis rs1448094 0.512 rs61930864 chr12:86246740 G/A cg00310523 chr12:86230176 RASSF9 0.35 5.85 0.31 1.16e-8 Major depressive disorder; CRC cis rs9322193 0.607 rs12527391 chr6:150203292 T/C cg07701084 chr6:150067640 NUP43 0.47 5.86 0.31 1.11e-8 Lung cancer; CRC trans rs12478296 0.892 rs11893879 chr2:243010411 G/A cg18288967 chr1:45987694 PRDX1 0.59 6.87 0.35 3.22e-11 Obesity-related traits; CRC cis rs7799006 0.606 rs878534 chr7:2314652 G/A cg08027265 chr7:2291960 NA -0.45 -7.47 -0.38 7.49e-13 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs67478160 0.619 rs8018062 chr14:104281954 C/T cg08213375 chr14:104286397 PPP1R13B 0.64 13.38 0.59 6.58e-33 Schizophrenia; CRC trans rs8123881 0.733 rs7268466 chr20:15810676 C/T cg06683288 chr20:60813424 OSBPL2 0.55 6.09 0.32 3.08e-9 Body mass index; CRC trans rs34421088 0.560 rs2467520 chr8:11398953 T/C cg06636001 chr8:8085503 FLJ10661 -0.54 -7.89 -0.4 4.51e-14 Neuroticism; CRC cis rs4563143 0.675 rs73029049 chr19:29275534 C/A cg14983838 chr19:29218262 NA 0.48 6.93 0.36 2.2e-11 Methadone dose in opioid dependence; CRC cis rs9910055 0.529 rs228767 chr17:42188311 C/G cg10896456 chr17:42255109 ASB16;C17orf65 -0.41 -6.36 -0.33 6.83e-10 Total body bone mineral density; CRC cis rs7945705 0.902 rs10769980 chr11:9014180 G/A cg00186954 chr11:8933980 ST5;C11orf17 0.43 6.59 0.34 1.73e-10 Hemoglobin concentration; CRC cis rs11677416 0.813 rs4848299 chr2:113523454 C/A cg27083787 chr2:113543245 IL1A 0.45 6.47 0.34 3.5e-10 Response to antipsychotic treatment in schizophrenia (working memory); CRC cis rs9910055 0.530 rs2269907 chr17:42294215 G/A cg13607699 chr17:42295918 UBTF 0.81 14.42 0.62 6.85e-37 Total body bone mineral density; CRC cis rs1552244 0.882 rs67631672 chr3:10004768 G/A cg18598329 chr3:10140678 FANCD2;C3orf24 -0.81 -10.68 -0.51 4.74e-23 Alzheimer's disease; CRC trans rs3942852 0.712 rs10742828 chr11:48104555 A/G cg03929089 chr4:120376271 NA -0.56 -7.03 -0.36 1.19e-11 Acute lymphoblastic leukemia (childhood); CRC cis rs6815814 0.950 rs55830619 chr4:38807364 G/A cg06935464 chr4:38784597 TLR10 0.55 5.68 0.3 2.97e-8 Breast cancer; CRC cis rs7552404 0.924 rs1313071 chr1:76195542 C/G cg03433033 chr1:76189801 ACADM 0.75 11.63 0.54 2.04e-26 Blood metabolite levels;Acylcarnitine levels; CRC cis rs57994353 0.897 rs72775772 chr9:139356738 C/T cg13856295 chr9:139396418 NOTCH1 -0.42 -5.64 -0.3 3.61e-8 Eosinophil counts;Cutaneous squamous cell carcinoma; CRC cis rs11122272 0.766 rs2024879 chr1:231528638 A/G cg06096015 chr1:231504339 EGLN1 0.41 6.16 0.32 2.18e-9 Hemoglobin concentration; CRC cis rs2880765 0.835 rs2170735 chr15:86043485 G/A cg17133734 chr15:86042851 AKAP13 0.42 6.71 0.35 8.42e-11 Coronary artery disease; CRC cis rs6502050 0.835 rs9898697 chr17:80100498 A/G cg09264619 chr17:80180166 NA -0.36 -6.17 -0.32 2.04e-9 Life satisfaction; CRC cis rs2014572 0.933 rs8107516 chr19:57758445 A/G cg24459738 chr19:57751996 ZNF805 -0.57 -9.05 -0.45 1.29e-17 Hyperactive-impulsive symptoms; CRC cis rs9303280 0.806 rs35736272 chr17:38032680 T/C cg11212589 chr17:38028394 ZPBP2 0.42 7.64 0.39 2.36e-13 Self-reported allergy; CRC cis rs9894429 1.000 rs11651264 chr17:79576394 A/G cg21984481 chr17:79567631 NPLOC4 0.53 9.8 0.48 4.52e-20 Eye color traits; CRC cis rs10484885 0.793 rs1465954 chr6:90475013 G/A cg13799429 chr6:90582589 CASP8AP2 0.75 9.77 0.47 5.9e-20 QRS interval (sulfonylurea treatment interaction); CRC cis rs11098499 0.955 rs11944880 chr4:120159334 A/G cg09307838 chr4:120376055 NA -0.62 -9.41 -0.46 8.82e-19 Corneal astigmatism; CRC cis rs6961069 0.713 rs1049654 chr7:80275455 A/C cg04458919 chr7:80252533 CD36 0.35 6.24 0.33 1.34e-9 Platelet count; CRC trans rs10504229 1.000 rs17216711 chr8:58170856 T/C cg04077850 chr5:125800366 GRAMD3 0.37 6.27 0.33 1.15e-9 Developmental language disorder (linguistic errors); CRC cis rs4728302 0.934 rs2971963 chr7:133641505 A/G cg10665199 chr7:133106180 EXOC4 -0.37 -5.77 -0.3 1.88e-8 Intelligence;Intelligence (multi-trait analysis); CRC cis rs6540559 1.000 rs6696825 chr1:209982372 A/G cg25204440 chr1:209979598 IRF6 0.49 7.07 0.36 9.33e-12 Cleft lip with or without cleft palate; CRC cis rs9910055 0.659 rs3826412 chr17:42255097 A/G cg19774624 chr17:42201019 HDAC5 -0.72 -11.58 -0.54 2.97e-26 Total body bone mineral density; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg17823320 chr8:19675140 INTS10 0.42 6.17 0.32 1.97e-9 Response to antipsychotic treatment; CRC cis rs3858526 0.883 rs10769320 chr11:5932831 G/C cg05234568 chr11:5960015 NA -0.52 -7.11 -0.37 7.18e-12 DNA methylation (variation); CRC cis rs8005677 0.962 rs10130756 chr14:23396600 C/G cg01529538 chr14:23388837 RBM23 0.4 6.22 0.32 1.51e-9 Cognitive ability (multi-trait analysis); CRC cis rs1218582 0.774 rs4845679 chr1:154861187 G/T cg06221963 chr1:154839813 KCNN3 -0.81 -16.69 -0.68 9.94e-46 Prostate cancer; CRC cis rs1129187 0.818 rs9462858 chr6:42946490 C/A cg05552183 chr6:42928497 GNMT 0.61 9.47 0.46 5.52e-19 Alzheimer's disease in APOE e4+ carriers; CRC cis rs10450586 0.863 rs7120368 chr11:27292742 C/T cg10370305 chr11:27303972 NA 0.38 6.19 0.32 1.81e-9 Total body bone mineral density; CRC cis rs478304 1.000 rs478304 chr11:65494260 G/T cg27068330 chr11:65405492 SIPA1 0.46 6.89 0.36 2.83e-11 Acne (severe); CRC cis rs965469 1.000 rs6051838 chr20:3389012 A/C cg25506879 chr20:3388711 C20orf194 -0.39 -6.02 -0.32 4.63e-9 IFN-related cytopenia; CRC trans rs951252 0.504 rs11734405 chr4:146081096 C/T cg06753227 chr18:9475508 RALBP1 0.48 6.37 0.33 6.55e-10 Hip circumference; CRC cis rs9470366 1.000 rs9470366 chr6:36625562 C/T cg08179530 chr6:36648295 CDKN1A 0.53 6.44 0.33 4.13e-10 QRS duration; CRC cis rs853679 0.517 rs9357063 chr6:28060005 G/A cg21251018 chr6:28226885 NKAPL 0.48 6.24 0.33 1.32e-9 Depression; CRC trans rs7618501 1.000 rs6775384 chr3:49853073 G/A cg21582582 chr3:182698605 DCUN1D1 0.55 8.11 0.41 1.01e-14 Intelligence (multi-trait analysis); CRC cis rs72772090 0.539 rs3334 chr5:96115085 G/C cg17330273 chr5:96107758 CAST;ERAP1 -0.7 -6.45 -0.34 3.94e-10 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs10504229 0.683 rs7843919 chr8:58130792 T/C cg22535103 chr8:58192502 C8orf71 -0.7 -9.34 -0.46 1.47e-18 Developmental language disorder (linguistic errors); CRC cis rs11690935 0.851 rs10174055 chr2:172858214 C/T cg13550731 chr2:172543902 DYNC1I2 -1.01 -15.61 -0.65 1.66e-41 Schizophrenia; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg25876656 chr1:210407480 C1orf133;SERTAD4 0.41 6.36 0.33 6.6e-10 Response to antipsychotic treatment; CRC cis rs668210 0.793 rs645571 chr11:65752852 A/T cg02202077 chr11:65769826 EIF1AD;BANF1 -0.54 -6.56 -0.34 2.13e-10 Cerebrospinal fluid biomarker levels; CRC cis rs780096 0.526 rs7602534 chr2:27592423 C/T cg12648201 chr2:27665141 KRTCAP3 -0.3 -5.85 -0.31 1.17e-8 Total body bone mineral density; CRC trans rs2732480 0.967 rs2732469 chr12:48712932 T/A cg05117785 chr10:94050880 CPEB3;MARCH5 0.45 6.37 0.33 6.44e-10 Hemoglobin concentration;Red blood cell count;Hematocrit; CRC trans rs13046373 0.905 rs4816372 chr21:32077414 A/T cg20073910 chr13:32889539 BRCA2 -0.47 -6.86 -0.35 3.34e-11 HDL cholesterol; CRC cis rs10504229 0.861 rs6990796 chr8:58183097 G/C cg01721255 chr8:58191610 C8orf71 0.49 6.17 0.32 2e-9 Developmental language disorder (linguistic errors); CRC cis rs6540556 0.954 rs2076150 chr1:209933540 A/G cg23920097 chr1:209922102 NA -0.52 -6.59 -0.34 1.72e-10 Red blood cell count; CRC cis rs801193 0.591 rs4506088 chr7:66135457 G/A cg00343986 chr7:65444356 GUSB -0.45 -6.18 -0.32 1.85e-9 Aortic root size; CRC cis rs875971 0.867 rs1002053 chr7:65798545 G/A cg18876405 chr7:65276391 NA -0.52 -9.03 -0.45 1.44e-17 Aortic root size; CRC cis rs1448094 0.791 rs7300340 chr12:86329867 G/T cg02569458 chr12:86230093 RASSF9 0.46 7.68 0.39 1.89e-13 Major depressive disorder; CRC cis rs2795502 0.515 rs116848302 chr10:43367783 G/A cg08461752 chr10:43522343 NA -0.75 -5.98 -0.31 5.67e-9 Blood protein levels; CRC cis rs9788721 1.000 rs8034191 chr15:78806023 A/G cg18825076 chr15:78729989 IREB2 -0.4 -5.79 -0.3 1.68e-8 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio;Emphysema imaging phenotypes;Emphysema distribution in smoking;Local histogram emphysema pattern;Post bronchodilator FEV1/FVC ratio in COPD; CRC cis rs7633770 0.931 rs12637421 chr3:46695074 T/C cg11219411 chr3:46661640 NA 0.64 10.58 0.5 1.07e-22 Coronary artery disease; CRC cis rs6964587 1.000 rs12531366 chr7:91683849 C/G cg17063962 chr7:91808500 NA 0.78 13.49 0.6 2.68e-33 Breast cancer; CRC trans rs1590305 0.786 rs61946592 chr13:38060148 T/C cg03965764 chr11:45248109 NA -0.6 -6.15 -0.32 2.31e-9 Hip geometry; CRC cis rs1707322 1.000 rs785504 chr1:46595696 C/T cg06784218 chr1:46089804 CCDC17 -0.55 -9.66 -0.47 1.33e-19 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs12824058 0.831 rs12310049 chr12:130811260 C/G cg24838063 chr12:130822603 PIWIL1 0.58 9.77 0.47 5.67e-20 Menopause (age at onset); CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg01182386 chr15:75182373 MPI 0.38 6.07 0.32 3.55e-9 Obesity-related traits; CRC cis rs6712932 0.925 rs10210149 chr2:105839324 C/T cg27422857 chr2:105853526 NA -0.36 -6.75 -0.35 6.82e-11 Type 2 diabetes; CRC cis rs244731 0.959 rs9313752 chr5:176645435 G/T cg05207973 chr5:176823642 SLC34A1 -0.43 -6.11 -0.32 2.87e-9 Urate levels in lean individuals; CRC trans rs12517041 1.000 rs6890216 chr5:23299559 G/A ch.8.1293020R chr8:59333349 UBXN2B -0.55 -6.17 -0.32 2.05e-9 Calcium levels; CRC cis rs6502050 0.835 rs7502548 chr17:80087569 T/C cg11859384 chr17:80120422 CCDC57 0.37 5.77 0.3 1.85e-8 Life satisfaction; CRC cis rs2880765 0.743 rs11630410 chr15:86004741 T/A cg17133734 chr15:86042851 AKAP13 0.41 6.47 0.34 3.48e-10 Coronary artery disease; CRC cis rs7107174 0.892 rs2511167 chr11:77964698 C/T cg02023728 chr11:77925099 USP35 0.52 7.87 0.4 5e-14 Testicular germ cell tumor; CRC cis rs6479527 0.875 rs10123954 chr9:96805860 A/G cg14459158 chr9:96720562 NA 0.38 6.71 0.35 8.37e-11 Esophageal adenocarcinoma; CRC cis rs2795502 1.000 rs2744092 chr10:43339343 T/C cg27426351 chr10:43362370 NA -0.6 -7.12 -0.37 6.96e-12 Blood protein levels; CRC cis rs6840360 0.550 rs4696288 chr4:152621150 A/C cg09659197 chr4:152720779 NA 0.32 5.71 0.3 2.48e-8 Intelligence (multi-trait analysis); CRC cis rs1670533 1.000 rs4690213 chr4:1054868 C/T cg27284194 chr4:1044797 NA 0.51 6.48 0.34 3.41e-10 Recombination rate (females); CRC cis rs11971779 0.553 rs7799742 chr7:139051878 C/T cg23387468 chr7:139079360 LUC7L2 0.41 7.09 0.36 7.99e-12 Diisocyanate-induced asthma; CRC cis rs6952808 0.692 rs60755037 chr7:2030104 G/A cg02951883 chr7:2050386 MAD1L1 -0.78 -12.8 -0.58 1.04e-30 Bipolar disorder and schizophrenia; CRC cis rs9302065 0.565 rs2992908 chr13:95960600 G/A cg26751094 chr13:95954534 ABCC4 -0.35 -6.15 -0.32 2.2e-9 Blood metabolite levels; CRC cis rs282587 0.597 rs1756075 chr13:113396211 T/C cg04656015 chr13:113407548 ATP11A 0.63 7.8 0.4 8.04e-14 Glycated hemoglobin levels; CRC cis rs4319547 0.585 rs7953007 chr12:122816977 A/C cg05707623 chr12:122985044 ZCCHC8 -0.69 -8.35 -0.42 1.89e-15 Body mass index; CRC cis rs2310173 0.575 rs4851527 chr2:102622376 C/T cg20856504 chr2:102616538 IL1R2 -0.37 -5.96 -0.31 6.45e-9 Ankylosing spondylitis;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined);Ulcerative colitis; CRC cis rs4888630 0.662 rs4888631 chr16:77470374 C/G cg10121788 chr16:77469583 ADAMTS18 0.34 5.78 0.3 1.77e-8 Lobe attachment (rater-scored or self-reported); CRC cis rs4862750 0.872 rs13143414 chr4:187878213 G/A cg11301795 chr4:187892539 NA -0.87 -20.55 -0.75 5.78e-61 Lobe attachment (rater-scored or self-reported); CRC cis rs10504229 0.906 rs116341227 chr8:58190532 G/C cg05313129 chr8:58192883 C8orf71 -0.47 -6.96 -0.36 1.82e-11 Developmental language disorder (linguistic errors); CRC cis rs6840360 1.000 rs10019048 chr4:152603615 A/G cg09659197 chr4:152720779 NA 0.5 10.7 0.51 3.85e-23 Intelligence (multi-trait analysis); CRC cis rs11166629 1.000 rs11166629 chr8:135636964 C/T cg27224718 chr8:135614730 ZFAT 0.5 7.52 0.38 5.1e-13 Smoking quantity; CRC cis rs950027 0.620 rs1426932 chr15:45687256 T/C cg21132104 chr15:45694354 SPATA5L1 0.41 5.76 0.3 1.89e-8 Response to fenofibrate (adiponectin levels); CRC cis rs870825 0.616 rs7680779 chr4:185652830 G/C cg04058563 chr4:185651563 MLF1IP -0.69 -8.69 -0.43 1.68e-16 Blood protein levels; CRC cis rs763014 0.966 rs4984677 chr16:671682 A/G cg07343612 chr16:622815 PIGQ -0.81 -13.69 -0.6 4.41e-34 Height; CRC cis rs919433 0.889 rs787998 chr2:198216092 A/G cg03934865 chr2:198174659 NA 0.36 5.78 0.3 1.77e-8 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC trans rs7726839 0.561 rs72703044 chr5:579737 G/A cg25482853 chr8:67687455 SGK3 1.01 12.23 0.56 1.28e-28 Obesity-related traits; CRC cis rs6988985 0.765 rs10096393 chr8:143984315 T/C cg10324643 chr8:143916377 GML 0.39 6.3 0.33 9.39e-10 Plasma androstenedione levels in resected early stage-receptor positive breast cancer; CRC trans rs9388451 0.839 rs11154331 chr6:126111429 A/T cg05039488 chr6:79577232 IRAK1BP1 -0.52 -7.98 -0.4 2.54e-14 Brugada syndrome; CRC cis rs972578 1.000 rs5751410 chr22:43393985 A/T cg01576275 chr22:43409880 NA -0.49 -8.02 -0.4 1.9e-14 Mean platelet volume; CRC cis rs7412746 0.658 rs11581757 chr1:150892244 A/G cg18016565 chr1:150552671 MCL1 0.43 6.18 0.32 1.9e-9 Melanoma; CRC cis rs17818399 0.547 rs4952833 chr2:46762034 T/C cg26688816 chr2:46740690 ATP6V1E2 -0.51 -6.4 -0.33 5.2e-10 Height; CRC cis rs11098499 0.710 rs6851130 chr4:120133712 G/A cg09307838 chr4:120376055 NA -0.53 -8.28 -0.42 3.06e-15 Corneal astigmatism; CRC trans rs2243480 1.000 rs437889 chr7:65509234 G/A cg10756647 chr7:56101905 PSPH 0.75 7.61 0.39 2.98e-13 Diabetic kidney disease; CRC cis rs4666002 0.917 rs4666000 chr2:27839369 T/C cg27432699 chr2:27873401 GPN1 0.44 5.75 0.3 2.06e-8 Phospholipid levels (plasma); CRC cis rs1008375 1.000 rs1008374 chr4:17683219 G/A cg04450456 chr4:17643702 FAM184B 0.41 6.53 0.34 2.48e-10 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs853679 0.517 rs9380050 chr6:28048538 A/G cg12172441 chr6:28176163 NA 0.59 7.12 0.37 6.82e-12 Depression; CRC cis rs877282 0.838 rs11253373 chr10:774857 A/G cg17470449 chr10:769945 NA 0.64 8.7 0.43 1.64e-16 Uric acid levels; CRC cis rs4638749 0.677 rs34449318 chr2:108827222 T/C cg25838818 chr2:108905173 SULT1C2 -0.34 -5.71 -0.3 2.52e-8 Blood pressure; CRC cis rs736408 0.509 rs2590838 chr3:52622086 G/A cg07507251 chr3:52567010 NT5DC2 0.46 7.06 0.36 1e-11 Bipolar disorder; CRC trans rs1455244 0.700 rs7229302 chr18:11508904 G/T cg04317338 chr11:64019027 PLCB3 0.42 6.47 0.34 3.63e-10 Schizophrenia; CRC cis rs9303280 0.806 rs9303279 chr17:38073968 G/C cg20243544 chr17:37824526 PNMT -0.39 -5.77 -0.3 1.82e-8 Self-reported allergy; CRC cis rs4722166 0.630 rs6969258 chr7:22782528 C/T cg26061582 chr7:22766209 IL6 0.55 8.35 0.42 1.92e-15 Lung cancer; CRC cis rs10944 0.598 rs1841991 chr5:78276148 C/T cg13121490 chr5:78280331 ARSB 0.46 6.72 0.35 7.98e-11 Blood and toenail selenium levels; CRC cis rs7666738 0.830 rs13134819 chr4:98919885 G/C cg17366294 chr4:99064904 C4orf37 0.43 7.24 0.37 3.24e-12 Colonoscopy-negative controls vs population controls; CRC cis rs9916302 0.706 rs667193 chr17:37448835 T/C cg07936489 chr17:37558343 FBXL20 0.83 10.32 0.49 8.05e-22 Glomerular filtration rate (creatinine); CRC cis rs910316 1.000 rs2300601 chr14:75639571 A/G cg03030879 chr14:75389066 RPS6KL1 -0.46 -6.94 -0.36 2.04e-11 Height; CRC cis rs2153535 0.580 rs7767756 chr6:8453428 A/C cg21535247 chr6:8435926 SLC35B3 0.5 7.46 0.38 7.85e-13 Motion sickness; CRC cis rs6547741 0.788 rs7595739 chr2:27874563 G/T cg27432699 chr2:27873401 GPN1 -0.82 -15.72 -0.65 6.47e-42 Oral cavity cancer; CRC cis rs6502050 0.799 rs12940433 chr17:80120826 C/T cg11859384 chr17:80120422 CCDC57 -0.36 -5.75 -0.3 2.06e-8 Life satisfaction; CRC cis rs4665809 0.590 rs35615763 chr2:26468778 C/G cg22920501 chr2:26401640 FAM59B 0.83 11.96 0.55 1.28e-27 Gut microbiome composition (summer); CRC trans rs9329221 0.967 rs7005363 chr8:10283748 C/T cg06636001 chr8:8085503 FLJ10661 -0.48 -7.59 -0.39 3.38e-13 Neuroticism; CRC cis rs11031096 0.727 rs2056853 chr11:4142172 C/T cg18678763 chr11:4115507 RRM1 -0.43 -7.32 -0.37 1.9e-12 Mean corpuscular volume;Mean corpuscular hemoglobin; CRC cis rs8177253 1.000 rs8177240 chr3:133477701 T/G cg24879335 chr3:133465180 TF 0.31 5.63 0.3 3.8e-8 Iron status biomarkers; CRC cis rs523522 0.673 rs643372 chr12:121022640 C/G cg12219531 chr12:120966889 COQ5 0.69 9.05 0.45 1.24e-17 High light scatter reticulocyte count; CRC cis rs4132509 0.739 rs10803150 chr1:243822600 C/T cg21452805 chr1:244014465 NA 0.58 7.22 0.37 3.6e-12 RR interval (heart rate); CRC cis rs3931020 0.530 rs12125889 chr1:75241971 A/G cg10128416 chr1:75198403 TYW3;CRYZ 0.51 6.86 0.35 3.52e-11 Resistin levels; CRC cis rs60843830 1.000 rs2290911 chr2:224919 A/G cg25945732 chr2:264204 ACP1;SH3YL1 0.73 11.62 0.54 2.21e-26 Spherical equivalent (joint analysis main effects and education interaction); CRC trans rs2228479 0.850 rs62054599 chr16:89808850 C/G cg24644049 chr4:85504048 CDS1 0.9 7.41 0.38 1.05e-12 Skin colour saturation; CRC cis rs4727027 0.933 rs4727028 chr7:148874666 A/G cg23583168 chr7:148888333 NA 0.9 15.61 0.65 1.72e-41 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC cis rs4713118 0.955 rs9393848 chr6:27688369 C/T cg15845792 chr6:28175446 NA 0.61 8.08 0.41 1.29e-14 Parkinson's disease; CRC cis rs875971 1.000 rs2220626 chr7:65546062 C/T cg00343986 chr7:65444356 GUSB -0.47 -6.94 -0.36 2.1e-11 Aortic root size; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg24234277 chr1:231473324 C1orf124;EXOC8 0.42 6.12 0.32 2.72e-9 Intelligence (multi-trait analysis); CRC cis rs514406 0.679 rs541852 chr1:53256834 A/G cg24675658 chr1:53192096 ZYG11B 0.79 12.27 0.56 9.13e-29 Monocyte count; CRC cis rs597539 0.652 rs667989 chr11:68685776 T/A cg04772025 chr11:68637568 NA 0.48 7.31 0.37 2.08e-12 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs2290405 1.000 rs2290405 chr4:946974 A/G cg04824913 chr4:887549 GAK -0.4 -6.02 -0.32 4.58e-9 Systemic sclerosis; CRC cis rs4803480 0.507 rs11083627 chr19:42069900 A/G cg08478046 chr19:42093086 CEACAM21 -0.28 -5.94 -0.31 7.32e-9 Schizophrenia; CRC trans rs7615952 0.733 rs13314847 chr3:125644788 C/T cg02560186 chr11:3602584 NA -0.46 -6.25 -0.33 1.3e-9 Blood pressure (smoking interaction); CRC cis rs7647973 0.710 rs6446284 chr3:49616997 A/G cg13072238 chr3:49761600 GMPPB -0.54 -5.85 -0.31 1.19e-8 Menarche (age at onset); CRC cis rs2243480 1.000 rs73142162 chr7:65374296 A/T cg25985355 chr7:65971099 NA -0.49 -5.61 -0.3 4.28e-8 Diabetic kidney disease; CRC cis rs7615952 0.512 rs2922175 chr3:125361360 T/C cg11143507 chr3:125485238 NA -0.58 -7.46 -0.38 7.69e-13 Blood pressure (smoking interaction); CRC cis rs9399135 0.636 rs7749106 chr6:135268142 G/A cg24558204 chr6:135376177 HBS1L 0.51 7.77 0.39 1.01e-13 Red blood cell count; CRC cis rs208520 0.954 rs72884027 chr6:66995044 T/G cg07460842 chr6:66804631 NA 0.92 11.19 0.53 7.51e-25 Exhaled nitric oxide output; CRC cis rs875971 0.545 rs10950036 chr7:65818228 G/T cg05627663 chr7:65219948 SNORA22;CCT6P1 0.57 7.4 0.38 1.16e-12 Aortic root size; CRC cis rs7584330 0.554 rs62186170 chr2:238425883 C/T cg14458575 chr2:238380390 NA 0.46 6.51 0.34 2.8e-10 Prostate cancer; CRC cis rs28386778 0.830 rs2597636 chr17:61876010 A/G cg07362569 chr17:61921086 SMARCD2 0.37 5.7 0.3 2.64e-8 Prudent dietary pattern; CRC trans rs1005277 0.579 rs1780115 chr10:38524773 C/T cg17830980 chr10:43048298 ZNF37B -0.57 -9.68 -0.47 1.16e-19 Extrinsic epigenetic age acceleration; CRC cis rs10504229 0.815 rs17805008 chr8:58160185 G/T cg24829409 chr8:58192753 C8orf71 -0.6 -8.06 -0.41 1.47e-14 Developmental language disorder (linguistic errors); CRC cis rs801193 1.000 rs4717319 chr7:66242593 A/G cg11764359 chr7:65958608 NA 0.52 8.08 0.41 1.24e-14 Aortic root size; CRC cis rs728616 0.867 rs56198874 chr10:81686488 C/T cg11900509 chr10:81946545 ANXA11 -0.66 -6.83 -0.35 4.01e-11 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs9549367 0.713 rs9549356 chr13:113851633 A/G cg24300038 chr13:113819356 PROZ -0.47 -5.78 -0.3 1.76e-8 Platelet distribution width; CRC cis rs798554 0.796 rs2158694 chr7:2863443 T/G cg04166393 chr7:2884313 GNA12 0.51 6.9 0.36 2.62e-11 Height; CRC cis rs9311474 0.713 rs352169 chr3:52236762 C/T cg08222913 chr3:52553049 STAB1 -0.35 -6.56 -0.34 2.1e-10 Electroencephalogram traits; CRC cis rs9611565 0.559 rs4822048 chr22:41988225 C/T cg03806693 chr22:41940476 POLR3H -1.04 -11.6 -0.54 2.54e-26 Vitiligo; CRC cis rs875971 0.862 rs908915 chr7:65614651 G/T cg00343986 chr7:65444356 GUSB -0.42 -6.04 -0.32 4.28e-9 Aortic root size; CRC cis rs2976388 0.609 rs2263092 chr8:143789966 A/G cg05569086 chr8:143859399 LYNX1 0.4 6.98 0.36 1.68e-11 Urinary tract infection frequency; CRC cis rs1059312 0.966 rs7135968 chr12:129280066 G/A cg21616243 chr12:129299702 MGC16384;SLC15A4 -0.66 -10.81 -0.51 1.69e-23 Systemic lupus erythematosus; CRC cis rs2303759 0.666 rs66967196 chr19:49808894 G/A cg24324837 chr19:49891574 CCDC155 0.52 6.81 0.35 4.65e-11 Multiple sclerosis; CRC cis rs6694672 0.850 rs1034162 chr1:197088303 G/A cg13682187 chr1:196946512 CFHR5 0.43 6.97 0.36 1.69e-11 Asthma; CRC cis rs9906695 0.846 rs1019109 chr17:32615120 A/G cg12698626 chr17:32581466 CCL2 0.45 6.03 0.32 4.36e-9 Monocyte percentage of white cells; CRC cis rs372883 0.507 rs8132992 chr21:30750561 T/C cg08807101 chr21:30365312 RNF160 0.49 7.29 0.37 2.29e-12 Pancreatic cancer; CRC cis rs4969178 0.965 rs4969179 chr17:76391454 A/C cg20026190 chr17:76395443 PGS1 0.38 5.97 0.31 6.12e-9 HDL cholesterol levels; CRC cis rs6714710 0.603 rs717417 chr2:98416850 T/G cg26665480 chr2:98280029 ACTR1B 0.56 7.47 0.38 7.19e-13 Posterior cortical atrophy and Alzheimer's disease; CRC cis rs9361491 0.510 rs1507151 chr6:79483246 T/C cg05283184 chr6:79620031 NA -0.44 -6.3 -0.33 9.77e-10 Intelligence (multi-trait analysis); CRC cis rs2274273 0.870 rs8023197 chr14:55767395 G/T cg23234261 chr14:55582407 NA -0.29 -5.84 -0.31 1.25e-8 Protein biomarker; CRC trans rs875971 0.545 rs73146609 chr7:65767464 A/G cg02869306 chr7:64672164 INTS4L1 -0.44 -6.45 -0.34 3.9e-10 Aortic root size; CRC cis rs2188554 0.740 rs6957018 chr7:117210368 C/T cg09181792 chr7:117119393 CFTR 0.35 5.98 0.31 5.8e-9 Esophageal adenocarcinoma; CRC cis rs2573652 1.000 rs2581358 chr15:100513725 C/G cg00587665 chr15:100533223 ADAMTS17 -0.35 -5.99 -0.31 5.46e-9 Height; CRC cis rs7726839 0.794 rs10053310 chr5:595661 C/G cg16447950 chr5:562315 NA -0.54 -8.11 -0.41 9.81e-15 Obesity-related traits; CRC trans rs4689592 0.619 rs3796908 chr4:7061378 G/A cg07817883 chr1:32538562 TMEM39B -0.66 -8.12 -0.41 9.72e-15 Monocyte percentage of white cells; CRC trans rs9329221 0.905 rs4610752 chr8:10248962 A/G cg08975724 chr8:8085496 FLJ10661 -0.42 -6.63 -0.34 1.35e-10 Neuroticism; CRC cis rs9309473 0.687 rs10165862 chr2:73610743 C/T cg20560298 chr2:73613845 ALMS1 -0.52 -6.94 -0.36 2.07e-11 Metabolite levels; CRC cis rs11148252 0.574 rs73186430 chr13:53232891 T/C cg00495681 chr13:53174319 NA 0.91 17.24 0.69 6.91e-48 Lewy body disease; CRC trans rs916888 0.610 rs199436 chr17:44789285 C/T cg10053473 chr17:62856997 LRRC37A3 0.65 8.9 0.44 3.76e-17 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs3733585 0.673 rs4314284 chr4:9956096 C/T cg00071950 chr4:10020882 SLC2A9 -0.54 -9.48 -0.46 5.08e-19 Cleft plate (environmental tobacco smoke interaction); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg25184507 chr17:7760147 CYB5D1;LSMD1 0.49 7.17 0.37 5.12e-12 Response to antipsychotic treatment; CRC cis rs28386778 0.897 rs6504185 chr17:61848792 A/G cg11494091 chr17:61959527 GH2 0.63 10.73 0.51 3.01e-23 Prudent dietary pattern; CRC cis rs6951245 0.638 rs4720486 chr7:1146764 G/A cg24642844 chr7:1081250 C7orf50 -0.5 -6.47 -0.34 3.52e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs7618915 0.547 rs11130317 chr3:52731483 C/T cg07507251 chr3:52567010 NT5DC2 0.42 5.97 0.31 6.11e-9 Bipolar disorder; CRC cis rs644799 1.000 rs1944074 chr11:95511445 C/A cg25622487 chr11:95524042 FAM76B;CEP57 0.76 11.68 0.54 1.28e-26 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC trans rs61931739 0.500 rs7307583 chr12:34521711 T/C cg13010199 chr12:38710504 ALG10B 0.46 6.6 0.34 1.67e-10 Morning vs. evening chronotype; CRC cis rs2949837 0.528 rs10260816 chr7:46010100 C/G cg10677697 chr7:45961126 IGFBP3 -0.37 -6.32 -0.33 8.58e-10 Sitting height ratio; CRC cis rs1005277 0.579 rs1740742 chr10:38518860 C/T cg00409905 chr10:38381863 ZNF37A -0.62 -10.29 -0.49 1.04e-21 Extrinsic epigenetic age acceleration; CRC trans rs11722228 0.522 rs881641 chr4:10133747 G/A cg26043149 chr18:55253948 FECH 1.14 19.56 0.73 4.48e-57 Gout;Urate levels;Serum uric acid levels; CRC cis rs1267303 0.675 rs1267312 chr1:46986748 C/G cg08533674 chr1:46993347 NA 0.63 8.13 0.41 8.62e-15 Monobrow; CRC cis rs362296 0.511 rs2051558 chr4:3324886 G/A cg08886695 chr4:3369023 RGS12 -0.42 -6.59 -0.34 1.79e-10 Parental longevity (mother's age at death); CRC cis rs9911578 1.000 rs2531729 chr17:56539890 C/T cg05425664 chr17:57184151 TRIM37 -0.52 -8.27 -0.41 3.34e-15 Intelligence (multi-trait analysis); CRC cis rs13108904 0.901 rs4974594 chr4:1300480 C/T cg23123621 chr4:1343375 KIAA1530 -0.34 -6.03 -0.32 4.48e-9 Obesity-related traits; CRC cis rs877282 0.945 rs71491303 chr10:772884 G/T cg17470449 chr10:769945 NA 0.6 8.43 0.42 1.1e-15 Uric acid levels; CRC cis rs4727027 0.727 rs1568944 chr7:148873497 A/T cg23583168 chr7:148888333 NA -0.75 -11.44 -0.53 9.95e-26 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC cis rs6121246 0.529 rs6060291 chr20:30198043 T/G cg13852791 chr20:30311386 BCL2L1 0.61 8.34 0.42 2e-15 Mean corpuscular hemoglobin; CRC cis rs6951245 0.935 rs118132455 chr7:1068232 C/A cg18402987 chr7:1209562 NA 0.64 6.77 0.35 6.03e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs477895 0.653 rs72918475 chr11:63878644 G/C cg23719950 chr11:63933701 MACROD1 -0.66 -8.08 -0.41 1.21e-14 Mean platelet volume; CRC cis rs2457480 0.571 rs61857479 chr10:44705516 A/G cg09554077 chr10:44749378 NA 0.53 7.12 0.37 6.78e-12 Coronary artery disease; CRC cis rs1046896 0.553 rs1044661 chr17:80901020 G/A cg17346650 chr17:80929145 B3GNTL1 0.47 7.13 0.37 6.45e-12 Glycated hemoglobin levels; CRC cis rs9467773 0.620 rs2498351 chr6:26659642 C/T cg09904177 chr6:26538194 HMGN4 0.72 11.39 0.53 1.47e-25 Intelligence (multi-trait analysis); CRC cis rs734999 0.588 rs2985859 chr1:2532416 T/C cg18854424 chr1:2615690 NA -0.42 -8.05 -0.41 1.56e-14 Ulcerative colitis; CRC cis rs6952808 0.929 rs1801368 chr7:1976457 C/T cg04267008 chr7:1944627 MAD1L1 -0.76 -10.49 -0.5 2.07e-22 Bipolar disorder and schizophrenia; CRC cis rs6502050 0.805 rs6502057 chr17:80082060 A/G cg22110888 chr17:80059540 CCDC57 -0.4 -6.26 -0.33 1.23e-9 Life satisfaction; CRC cis rs7589728 1.000 rs75309929 chr2:88524377 T/C cg04511125 chr2:88470314 THNSL2 0.73 7.5 0.38 6.15e-13 Plasma clusterin levels; CRC cis rs9435341 0.965 rs3108680 chr1:107572997 T/C cg09367891 chr1:107599246 PRMT6 0.59 9.47 0.46 5.54e-19 Facial morphology (factor 21, depth of nasal alae); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg05519737 chr2:111435625 BUB1 0.41 6.11 0.32 2.85e-9 Intelligence (multi-trait analysis); CRC cis rs6446298 0.738 rs1060970 chr3:49708769 T/C cg03060546 chr3:49711283 APEH 0.54 6.79 0.35 5.22e-11 Intelligence (multi-trait analysis); CRC cis rs2066819 1.000 rs111885088 chr12:56657216 A/C cg26714650 chr12:56694279 CS -1.38 -11.34 -0.53 2.14e-25 Psoriasis vulgaris; CRC cis rs10504229 0.683 rs79284841 chr8:58107611 T/A cg02290350 chr8:58132656 NA -0.6 -6.78 -0.35 5.45e-11 Developmental language disorder (linguistic errors); CRC cis rs611744 0.583 rs1448148 chr8:109333074 T/A cg21045802 chr8:109455806 TTC35 0.5 7.86 0.4 5.53e-14 Dupuytren's disease; CRC cis rs9682041 0.808 rs9880558 chr3:170067771 A/G cg11886554 chr3:170076028 SKIL -0.68 -7.69 -0.39 1.69e-13 Glomerular filtration rate in non diabetics (creatinine);Glomerular filtration rate (creatinine); CRC cis rs12410462 1.000 rs75360545 chr1:227625419 T/C cg04117972 chr1:227635322 NA 0.69 7.82 0.4 7.23e-14 Major depressive disorder; CRC cis rs7259376 0.902 rs10414591 chr19:22600122 G/A cg02657401 chr19:22469223 NA 0.31 6.82 0.35 4.25e-11 Menopause (age at onset); CRC cis rs7666738 0.830 rs17550630 chr4:99008332 G/T cg05340658 chr4:99064831 C4orf37 0.61 9.54 0.47 3.44e-19 Colonoscopy-negative controls vs population controls; CRC cis rs7937682 0.889 rs559482 chr11:111497902 G/A cg09085632 chr11:111637200 PPP2R1B -1.01 -20.11 -0.74 3.19e-59 Primary sclerosing cholangitis; CRC cis rs8040855 0.627 rs3816105 chr15:85640911 G/A cg10818794 chr15:86012489 AKAP13 -0.42 -5.65 -0.3 3.4e-8 Bulimia nervosa; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg15174977 chr3:52931857 TMEM110 0.39 6.02 0.31 4.55e-9 Intelligence (multi-trait analysis); CRC cis rs9487051 0.735 rs352837 chr6:109521806 C/T cg21918786 chr6:109611834 NA 0.36 6.17 0.32 2.02e-9 Reticulocyte fraction of red cells; CRC cis rs2230307 0.572 rs621212 chr1:100559281 T/C cg24955406 chr1:100503596 HIAT1 0.51 6.07 0.32 3.58e-9 Carotid intima media thickness; CRC cis rs1178968 1.000 rs4717085 chr7:72764807 C/T cg25889504 chr7:72793014 NA 0.54 6.12 0.32 2.63e-9 Triglyceride levels; CRC cis rs2233152 0.520 rs56101381 chr19:41272902 T/C cg21869046 chr19:41225005 ITPKC 0.43 6.81 0.35 4.59e-11 Kawasaki disease; CRC cis rs763121 0.853 rs5757232 chr22:39071677 C/T cg06544989 chr22:39130855 UNC84B 0.45 6.9 0.36 2.7e-11 Menopause (age at onset); CRC cis rs2179367 0.959 rs579789 chr6:149679371 A/G cg16235748 chr6:149772707 ZC3H12D -0.35 -5.68 -0.3 2.9e-8 Dupuytren's disease; CRC cis rs611744 0.550 rs57045491 chr8:109279120 A/C cg21045802 chr8:109455806 TTC35 0.44 7.03 0.36 1.18e-11 Dupuytren's disease; CRC cis rs4838594 0.537 rs2166224 chr10:49696926 G/A cg17291251 chr10:49678358 ARHGAP22 0.41 6.39 0.33 5.73e-10 Daytime sleep phenotypes; CRC cis rs1904096 0.506 rs114312933 chr4:95216802 C/T cg11021082 chr4:95130006 SMARCAD1 -0.58 -9.33 -0.46 1.66e-18 Type 2 diabetes; CRC cis rs67981189 0.529 rs61990387 chr14:71491567 A/G cg15910301 chr14:71632612 NA 0.31 6.07 0.32 3.44e-9 Schizophrenia; CRC cis rs12142240 0.698 rs7548675 chr1:46809321 C/G cg00530320 chr1:46809349 NSUN4 0.58 7.98 0.4 2.46e-14 Menopause (age at onset); CRC cis rs4363385 0.740 rs4845518 chr1:153003903 A/G cg25856811 chr1:152973957 SPRR3 -0.26 -7.26 -0.37 2.79e-12 Inflammatory skin disease; CRC cis rs734999 0.588 rs2260976 chr1:2527678 A/G cg18854424 chr1:2615690 NA -0.41 -7.84 -0.4 6.43e-14 Ulcerative colitis; CRC trans rs2727020 0.729 rs2866328 chr11:49282421 A/G cg11707556 chr5:10655725 ANKRD33B 0.35 6.41 0.33 5.17e-10 Coronary artery disease; CRC cis rs9359856 0.529 rs6935307 chr6:90295350 A/G cg13799429 chr6:90582589 CASP8AP2 0.73 7.7 0.39 1.65e-13 Bipolar disorder; CRC trans rs10983614 1.000 rs7867776 chr9:120072627 A/G cg11467262 chr20:57607340 ATP5E 0.47 6.35 0.33 7.09e-10 Survival in pancreatic cancer; CRC cis rs9287719 0.967 rs6759740 chr2:10747271 A/G cg00105475 chr2:10696890 NA 0.45 7.15 0.37 5.48e-12 Prostate cancer; CRC cis rs6804368 0.649 rs9838795 chr3:30758991 C/T cg06106510 chr3:30762233 NA 0.35 6.38 0.33 5.86e-10 Blood metabolite levels; CRC cis rs2032447 0.802 rs199755 chr6:25990367 G/A cg26028573 chr6:26043587 HIST1H2BB 0.48 7.04 0.36 1.11e-11 Intelligence (multi-trait analysis); CRC trans rs2243480 1.000 rs1979823 chr7:65704613 G/A cg10756647 chr7:56101905 PSPH -0.79 -8.16 -0.41 7.21e-15 Diabetic kidney disease; CRC cis rs9487051 0.676 rs6568567 chr6:109596993 A/G cg01475377 chr6:109611718 NA -0.37 -6.58 -0.34 1.85e-10 Reticulocyte fraction of red cells; CRC trans rs2303319 0.504 rs62189051 chr2:162622318 G/A cg10498984 chr16:28874827 SH2B1 -0.73 -6.28 -0.33 1.04e-9 Cognitive function; CRC cis rs9660992 0.710 rs1768587 chr1:205236432 C/T cg21643547 chr1:205240462 TMCC2 -0.46 -7.28 -0.37 2.54e-12 Mean corpuscular volume;Mean platelet volume; CRC cis rs9488822 0.596 rs13192549 chr6:116338352 C/A cg26893134 chr6:116381904 FRK 0.25 6.75 0.35 6.63e-11 Cholesterol, total;LDL cholesterol; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg05979741 chr2:110873485 MALL 0.49 7.02 0.36 1.27e-11 Response to antipsychotic treatment; CRC cis rs17095355 1.000 rs12265204 chr10:111752163 T/C cg00817464 chr10:111662876 XPNPEP1 -0.58 -7.3 -0.37 2.17e-12 Biliary atresia; CRC cis rs2197308 0.765 rs11182992 chr12:37935572 G/C cg13010199 chr12:38710504 ALG10B 0.44 5.62 0.3 4.08e-8 Morning vs. evening chronotype; CRC cis rs929354 1.000 rs8101 chr7:157061474 A/G cg16102536 chr7:156981717 UBE3C -0.39 -6.66 -0.34 1.16e-10 Body mass index; CRC cis rs10256972 0.504 rs2949178 chr7:1209925 T/C cg23978390 chr7:1156363 C7orf50 0.41 5.65 0.3 3.47e-8 Longevity;Endometriosis; CRC cis rs7312933 0.670 rs10880269 chr12:42606135 C/T cg19980929 chr12:42632907 YAF2 0.44 6.51 0.34 2.88e-10 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CRC cis rs9814567 0.752 rs13064209 chr3:134335993 T/C cg06109529 chr3:134205091 CEP63;ANAPC13 0.68 9.98 0.48 1.12e-20 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs7945705 0.967 rs10840141 chr11:8902218 T/C cg12365402 chr11:9010492 NRIP3 0.47 7.77 0.39 9.82e-14 Hemoglobin concentration; CRC cis rs1878931 0.582 rs9921152 chr16:3421199 A/G cg02880119 chr16:3481970 NA -0.41 -5.8 -0.3 1.55e-8 Body mass index (adult); CRC cis rs10905065 0.866 rs10795547 chr10:5827074 A/G cg25171089 chr10:5708825 ASB13 -0.41 -5.84 -0.31 1.25e-8 Menopause (age at onset); CRC cis rs55692411 0.537 rs35375092 chr3:50065274 G/A cg05623727 chr3:50126028 RBM5 0.53 6.69 0.35 9.47e-11 Intelligence (multi-trait analysis); CRC cis rs17433780 0.964 rs12146148 chr1:89471892 C/T cg09516651 chr1:89888402 LOC400759 0.46 6.95 0.36 1.91e-11 Carotid intima media thickness; CRC cis rs11148252 0.846 rs7323666 chr13:53006058 T/C cg12458913 chr13:53173898 NA 0.55 8.49 0.42 7.28e-16 Lewy body disease; CRC cis rs62103177 0.525 rs10438902 chr18:77745640 A/G cg20368463 chr18:77673604 PQLC1 -0.51 -5.88 -0.31 1.03e-8 Opioid sensitivity; CRC cis rs8180040 0.726 rs34344887 chr3:47042161 A/G cg27129171 chr3:47204927 SETD2 0.76 12.56 0.57 8.02e-30 Colorectal cancer; CRC cis rs10870270 1.000 rs4880263 chr10:133787629 C/T cg08754478 chr10:133766260 PPP2R2D -0.65 -9.08 -0.45 1.05e-17 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; CRC cis rs853679 0.517 rs4713148 chr6:28115921 G/A cg06470822 chr6:28175283 NA 1.03 13.59 0.6 1.04e-33 Depression; CRC cis rs4713118 0.955 rs9468206 chr6:27690453 G/T cg12273811 chr6:28175739 NA 0.52 7.02 0.36 1.28e-11 Parkinson's disease; CRC trans rs3806843 0.766 rs801176 chr5:140087010 A/G cg06840491 chr10:48416966 GDF2 0.34 5.98 0.31 5.79e-9 Depressive symptoms (multi-trait analysis); CRC trans rs11098499 0.909 rs1809406 chr4:120377122 G/A cg25214090 chr10:38739885 LOC399744 0.66 10.56 0.5 1.18e-22 Corneal astigmatism; CRC cis rs172166 0.694 rs1150666 chr6:28123928 T/C cg20615401 chr6:28092323 ZSCAN16 0.45 5.94 0.31 7.33e-9 Cardiac Troponin-T levels; CRC cis rs6582630 0.503 rs4882293 chr12:38388200 G/C cg13010199 chr12:38710504 ALG10B -0.4 -5.71 -0.3 2.52e-8 Drug-induced liver injury (flucloxacillin); CRC trans rs7210990 0.724 rs178826 chr17:16083684 C/T cg01061575 chr22:45098367 PRR5-ARHGAP8;PRR5 -0.45 -6.26 -0.33 1.22e-9 Neutrophil percentage of white cells;Lymphocyte percentage of white cells; CRC trans rs1814175 0.817 rs1794164 chr11:49899610 T/C cg11707556 chr5:10655725 ANKRD33B -0.42 -7.98 -0.4 2.5e-14 Height; CRC cis rs9549367 0.664 rs9549689 chr13:113848387 G/A cg24300038 chr13:113819356 PROZ -0.47 -5.78 -0.3 1.76e-8 Platelet distribution width; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg24663636 chr14:35872875 NFKBIA 0.47 7.22 0.37 3.52e-12 Liver disease severity in Alagille syndrome; CRC cis rs9611565 0.921 rs4822021 chr22:41726053 G/A cg03806693 chr22:41940476 POLR3H -0.86 -11.89 -0.55 2.28e-27 Vitiligo; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg27574168 chr18:54318782 WDR7 0.47 6.01 0.31 4.85e-9 Thyroid stimulating hormone; CRC trans rs2727020 0.681 rs2866362 chr11:49379316 A/G cg21153622 chr11:89784906 NA -0.41 -6.78 -0.35 5.7e-11 Coronary artery disease; CRC cis rs694739 1.000 rs499425 chr11:64105929 A/G cg23796481 chr11:64053134 BAD;GPR137 -0.56 -8.43 -0.42 1.08e-15 Alopecia areata;Crohn's disease;Psoriasis vulgaris; CRC cis rs2274273 0.870 rs13379169 chr14:55741287 C/T cg23234261 chr14:55582407 NA -0.29 -5.81 -0.3 1.49e-8 Protein biomarker; CRC cis rs6831352 0.877 rs29001183 chr4:100056539 C/T cg13256891 chr4:100009986 ADH5 -0.66 -8.89 -0.44 4.04e-17 Alcohol dependence; CRC cis rs644799 1.000 rs617999 chr11:95589935 A/G cg03916912 chr11:95522834 CEP57;FAM76B 0.97 18.46 0.71 1.04e-52 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs4731207 0.565 rs12536146 chr7:124600631 T/A cg23710748 chr7:124431027 NA -0.38 -5.99 -0.31 5.5e-9 Cutaneous malignant melanoma; CRC cis rs561341 1.000 rs550264 chr17:30317540 G/T cg19193384 chr17:30244184 NA -0.65 -7.57 -0.39 3.82e-13 Hip circumference adjusted for BMI; CRC cis rs2630709 0.562 rs2115366 chr2:8464031 C/T cg12167548 chr2:8464763 NA 0.33 6.32 0.33 8.39e-10 Monocyte percentage of white cells; CRC cis rs6586163 1.000 rs6586164 chr10:90752031 T/A cg13456138 chr10:90753195 FAS -0.44 -6.87 -0.35 3.31e-11 Chronic lymphocytic leukemia; CRC cis rs12188164 0.686 rs56279338 chr5:416118 G/A cg16322479 chr5:444228 EXOC3;C5orf55 0.4 6.41 0.33 5.03e-10 Cystic fibrosis severity; CRC cis rs747650 0.699 rs4237547 chr11:47236405 C/G cg19486271 chr11:47235900 DDB2 -0.52 -8.2 -0.41 5.28e-15 Acne (severe); CRC cis rs889312 0.500 rs865570 chr5:56161975 C/T cg12311346 chr5:56204834 C5orf35 -0.46 -6.99 -0.36 1.52e-11 Breast cancer;Breast cancer (early onset); CRC cis rs4494114 1.000 rs4494114 chr1:39339682 C/T cg25970120 chr1:39325951 RRAGC 0.41 5.61 0.3 4.29e-8 Blood protein levels; CRC cis rs8180040 0.966 rs3816779 chr3:47543389 C/T cg27129171 chr3:47204927 SETD2 0.53 8.27 0.41 3.43e-15 Colorectal cancer; CRC cis rs951366 0.789 rs823097 chr1:205681370 G/A cg26354017 chr1:205819088 PM20D1 0.72 10.53 0.5 1.48e-22 Menarche (age at onset); CRC cis rs10991814 0.764 rs75062481 chr9:94094222 G/A cg14446406 chr9:93919335 NA 0.6 6.61 0.34 1.52e-10 Neutrophil percentage of granulocytes; CRC cis rs4660306 0.961 rs4660867 chr1:45986484 A/G cg03123370 chr1:45965343 CCDC163P;MMACHC -0.55 -7.81 -0.4 7.94e-14 Homocysteine levels; CRC cis rs11758351 1.000 rs80259160 chr6:26190199 C/T cg01420254 chr6:26195488 NA 0.81 8.55 0.43 4.7e-16 Gout;Renal underexcretion gout; CRC trans rs12478296 0.901 rs58906257 chr2:243028248 T/C cg06834434 chr14:75079333 LTBP2 0.51 6.1 0.32 3.05e-9 Obesity-related traits; CRC cis rs75920871 0.528 rs4388921 chr11:116976778 T/C cg01368799 chr11:117014884 PAFAH1B2 -0.43 -6.05 -0.32 4.01e-9 Subjective well-being; CRC cis rs6426558 0.515 rs7521110 chr1:227384459 T/A cg10327440 chr1:227177885 CDC42BPA -0.42 -6.29 -0.33 1.03e-9 Neutrophil percentage of white cells; CRC cis rs9467711 0.606 rs2073529 chr6:26375159 C/T cg14345882 chr6:26364793 BTN3A2 -0.64 -5.82 -0.31 1.43e-8 Autism spectrum disorder or schizophrenia; CRC cis rs12048904 0.541 rs6699536 chr1:101276544 A/G cg15686842 chr1:101360669 SLC30A7;EXTL2 0.53 7.06 0.36 9.95e-12 Multiple sclerosis; CRC cis rs832540 0.931 rs1445996 chr5:56235548 C/T cg12311346 chr5:56204834 C5orf35 0.5 7.65 0.39 2.28e-13 Coronary artery disease; CRC cis rs853679 0.769 rs7752448 chr6:28301099 A/G cg12273811 chr6:28175739 NA 0.63 6.09 0.32 3.18e-9 Depression; CRC cis rs11764590 0.715 rs9969125 chr7:2088460 C/T cg13880726 chr7:1868755 MAD1L1 -0.47 -5.68 -0.3 2.89e-8 Neuroticism; CRC cis rs713477 1.000 rs12893000 chr14:55912280 G/T cg13175173 chr14:55914753 NA -0.51 -9.55 -0.47 3.01e-19 Pediatric bone mineral content (femoral neck); CRC trans rs6956675 0.915 rs7790432 chr7:62631824 T/C cg01314568 chr7:57830625 NA -0.66 -9.21 -0.45 3.98e-18 Obesity-related traits; CRC cis rs2011503 1.000 rs2011503 chr19:19443986 C/T cg11584989 chr19:19387371 SF4 0.54 6.34 0.33 7.71e-10 Bipolar disorder; CRC cis rs728616 0.867 rs56008106 chr10:81953776 T/C cg11900509 chr10:81946545 ANXA11 -0.77 -7.46 -0.38 7.71e-13 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs7811142 0.830 rs6965458 chr7:99973402 G/A cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.55 6.65 0.34 1.22e-10 Platelet count; CRC cis rs8099014 0.731 rs4940391 chr18:56105868 A/G cg19312305 chr18:56117016 MIR122 -0.44 -5.96 -0.31 6.53e-9 Platelet count; CRC cis rs9611565 0.694 rs202628 chr22:41849513 A/G cg03806693 chr22:41940476 POLR3H -0.95 -13.13 -0.59 5.77e-32 Vitiligo; CRC cis rs7772486 0.686 rs9376956 chr6:145949844 T/C cg23711669 chr6:146136114 FBXO30 0.65 10.8 0.51 1.79e-23 Lobe attachment (rater-scored or self-reported); CRC cis rs356992 0.915 rs356976 chr2:60748945 C/T cg08426369 chr2:60753602 BCL11A -0.47 -5.73 -0.3 2.33e-8 Educational attainment (years of education); CRC cis rs7617773 0.780 rs7653336 chr3:48369464 T/A cg11946769 chr3:48343235 NME6 0.72 9.58 0.47 2.48e-19 Coronary artery disease; CRC cis rs1799949 1.000 rs915945 chr17:41179864 C/T cg23758822 chr17:41437982 NA 0.82 13.38 0.59 6.95e-33 Menopause (age at onset); CRC cis rs6952808 0.929 rs11761270 chr7:1923695 C/T cg21782813 chr7:2030301 MAD1L1 0.46 7.95 0.4 2.97e-14 Bipolar disorder and schizophrenia; CRC cis rs9300255 0.543 rs1617156 chr12:123590165 T/C cg00376283 chr12:123451042 ABCB9 0.56 7.14 0.37 6.15e-12 Neutrophil percentage of white cells; CRC cis rs12024301 0.557 rs78209243 chr1:183633664 A/G cg11505048 chr1:183622726 RGL1;APOBEC4 0.78 6.93 0.36 2.18e-11 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs2153535 0.580 rs9505446 chr6:8448691 T/C cg07606381 chr6:8435919 SLC35B3 0.68 10.85 0.51 1.22e-23 Motion sickness; CRC cis rs6662572 0.737 rs7525281 chr1:46267923 A/G cg03123370 chr1:45965343 CCDC163P;MMACHC -0.48 -6.22 -0.32 1.52e-9 Blood protein levels; CRC trans rs60843830 1.000 rs7566279 chr2:281178 C/G cg11347411 chr7:150020925 ACTR3C;LRRC61 0.61 9.57 0.47 2.64e-19 Spherical equivalent (joint analysis main effects and education interaction); CRC cis rs75920871 0.528 rs11216240 chr11:116899248 A/T cg20608306 chr11:116969690 SIK3 -0.32 -6.12 -0.32 2.69e-9 Subjective well-being; CRC cis rs2243480 1.000 rs451396 chr7:65484074 T/A cg12463550 chr7:65579703 CRCP 0.7 6.44 0.33 4.33e-10 Diabetic kidney disease; CRC cis rs4474465 0.850 rs10899528 chr11:78207686 T/C cg27205649 chr11:78285834 NARS2 0.47 5.82 0.31 1.41e-8 Alzheimer's disease (survival time); CRC trans rs62295889 0.602 rs56660601 chr4:12536363 G/A cg03490839 chr16:73082051 ZFHX3 0.58 6.06 0.32 3.82e-9 Obesity-related traits; CRC cis rs3785574 0.962 rs4480868 chr17:61788859 C/T cg25654072 chr17:61904446 PSMC5;FTSJ3 0.45 6.5 0.34 2.98e-10 Height; CRC cis rs270601 0.770 rs932019 chr5:131599370 T/C cg27615366 chr5:131592974 PDLIM4 0.34 6.46 0.34 3.81e-10 Acylcarnitine levels; CRC cis rs4363385 0.747 rs6689609 chr1:152967588 G/A cg25856811 chr1:152973957 SPRR3 -0.25 -7.05 -0.36 1.03e-11 Inflammatory skin disease; CRC cis rs2239547 0.522 rs2581780 chr3:53058960 C/T cg11645453 chr3:52864694 ITIH4 -0.54 -9.37 -0.46 1.17e-18 Schizophrenia; CRC cis rs10504229 0.593 rs74760806 chr8:58024785 C/T cg21724239 chr8:58056113 NA 0.58 7.75 0.39 1.17e-13 Developmental language disorder (linguistic errors); CRC cis rs7647973 1.000 rs6446268 chr3:49445695 G/A cg20833759 chr3:49053208 WDR6;DALRD3 -0.54 -7.97 -0.4 2.66e-14 Menarche (age at onset); CRC cis rs6163 0.588 rs12763284 chr10:104508202 C/T cg04362960 chr10:104952993 NT5C2 -0.46 -6.93 -0.36 2.22e-11 Waist circumference;Hip circumference; CRC cis rs11628318 0.715 rs1815262 chr14:103056926 C/T cg08075719 chr14:103021372 NA -0.66 -7.49 -0.38 6.38e-13 Platelet count; CRC cis rs72781680 1.000 rs72781671 chr2:24231123 A/G cg08917208 chr2:24149416 ATAD2B 1.03 9.91 0.48 2.04e-20 Lymphocyte counts; CRC cis rs7512552 0.839 rs11587116 chr1:150451898 A/T cg15654264 chr1:150340011 RPRD2 0.58 8.35 0.42 1.89e-15 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); CRC cis rs9322193 0.847 rs56103941 chr6:150137231 A/G cg05861140 chr6:150128134 PCMT1 -0.4 -6.05 -0.32 4e-9 Lung cancer; CRC cis rs10782582 0.586 rs5745383 chr1:76288590 G/C cg03433033 chr1:76189801 ACADM -0.4 -5.71 -0.3 2.49e-8 Daytime sleep phenotypes; CRC trans rs2270927 0.510 rs6891108 chr5:75579152 C/A cg13563193 chr19:33072644 PDCD5 0.68 6.15 0.32 2.29e-9 Mean corpuscular volume; CRC cis rs6540556 0.723 rs6540550 chr1:209925251 A/G cg23920097 chr1:209922102 NA -0.53 -6.53 -0.34 2.51e-10 Red blood cell count; CRC cis rs4285028 0.948 rs13089878 chr3:121703895 T/C cg11130432 chr3:121712080 ILDR1 -0.51 -6.71 -0.35 8.74e-11 Multiple sclerosis; CRC cis rs4237845 0.742 rs6650219 chr12:58289100 T/C cg00677455 chr12:58241039 CTDSP2 0.53 7.63 0.39 2.48e-13 Intelligence (multi-trait analysis); CRC cis rs6499255 0.951 rs1437136 chr16:69672675 G/C cg04110750 chr16:69646130 NFAT5 -0.56 -7.63 -0.39 2.6e-13 IgE levels; CRC cis rs1816752 0.905 rs4770666 chr13:24989029 T/C cg02811702 chr13:24901961 NA 0.41 5.73 0.3 2.28e-8 Obesity-related traits; CRC cis rs780096 0.526 rs7594812 chr2:27611469 A/G cg24768116 chr2:27665128 KRTCAP3 -0.35 -7.84 -0.4 6.39e-14 Total body bone mineral density; CRC cis rs59918340 0.616 rs3739222 chr8:142205904 C/G cg23750338 chr8:142222470 SLC45A4 0.59 10.52 0.5 1.7e-22 Immature fraction of reticulocytes; CRC cis rs294883 0.739 rs34147307 chr6:159732212 G/A cg14500486 chr6:159655392 FNDC1 -0.36 -6.18 -0.32 1.92e-9 Coronary artery disease; CRC trans rs13046373 0.905 rs4816372 chr21:32077414 A/T cg08558996 chr3:32775935 CNOT10 -0.38 -6.04 -0.32 4.11e-9 HDL cholesterol; CRC cis rs2495707 0.624 rs2489008 chr10:102422934 C/T cg22689833 chr10:102415991 NA -0.35 -6.73 -0.35 7.53e-11 Body mass index; CRC cis rs875971 0.545 rs6961853 chr7:66002022 G/A cg03233332 chr7:66118400 NA -0.43 -6.02 -0.31 4.74e-9 Aortic root size; CRC cis rs4713118 0.868 rs10484401 chr6:27746590 A/T cg20933634 chr6:27740509 NA -0.59 -6.89 -0.36 2.79e-11 Parkinson's disease; CRC cis rs6840360 0.837 rs13146981 chr4:152720703 T/C cg09659197 chr4:152720779 NA -0.54 -11.87 -0.55 2.67e-27 Intelligence (multi-trait analysis); CRC cis rs6921919 0.583 rs7764722 chr6:28354533 C/T cg21251018 chr6:28226885 NKAPL 0.39 6.04 0.32 4.08e-9 Autism spectrum disorder or schizophrenia; CRC cis rs6461049 0.800 rs2398706 chr7:2156338 A/T cg04267008 chr7:1944627 MAD1L1 -0.49 -6.82 -0.35 4.25e-11 Schizophrenia; CRC cis rs9322193 0.923 rs10782311 chr6:149943728 A/G cg00933542 chr6:150070202 PCMT1 0.29 6.12 0.32 2.69e-9 Lung cancer; CRC cis rs457287 0.892 rs1260032 chr9:4829487 T/C cg14182974 chr9:4791918 RCL1 0.42 6.68 0.35 1.05e-10 Platelet count; CRC cis rs1552244 1.000 rs7611218 chr3:10063960 T/C cg16606324 chr3:10149918 C3orf24 0.69 9.43 0.46 7.91e-19 Alzheimer's disease; CRC cis rs6570726 0.755 rs2092297 chr6:145893765 A/G cg23711669 chr6:146136114 FBXO30 0.69 11.52 0.54 4.94e-26 Lobe attachment (rater-scored or self-reported); CRC cis rs6831352 0.879 rs29001229 chr4:100046823 A/G cg13256891 chr4:100009986 ADH5 -0.66 -8.92 -0.44 3.21e-17 Alcohol dependence; CRC cis rs736408 0.527 rs2336147 chr3:52626443 T/C cg05573699 chr3:52720067 GNL3;PBRM1 -0.54 -8.31 -0.42 2.61e-15 Bipolar disorder; CRC cis rs9457247 0.765 rs9457249 chr6:167426438 A/G cg07741184 chr6:167504864 NA 0.39 6.72 0.35 8.06e-11 Crohn's disease; CRC cis rs7666738 0.830 rs1559859 chr4:99024325 C/T cg05340658 chr4:99064831 C4orf37 0.62 9.56 0.47 2.92e-19 Colonoscopy-negative controls vs population controls; CRC cis rs782590 0.967 rs782586 chr2:55836165 A/C cg18811423 chr2:55921094 PNPT1 0.83 15.15 0.64 1.07e-39 Metabolic syndrome; CRC cis rs9891119 0.550 rs9912773 chr17:40510534 C/G cg06270615 chr17:40516068 STAT3 -0.33 -6.41 -0.33 4.98e-10 Multiple sclerosis;Crohn's disease; CRC cis rs763121 0.626 rs5757236 chr22:39073824 T/C cg06544989 chr22:39130855 UNC84B 0.45 6.9 0.36 2.7e-11 Menopause (age at onset); CRC cis rs10504229 0.683 rs113492050 chr8:58130046 A/G cg02725872 chr8:58115012 NA -0.64 -11.55 -0.54 3.85e-26 Developmental language disorder (linguistic errors); CRC cis rs7918232 0.941 rs4749230 chr10:27441218 C/T cg14240646 chr10:27532245 ACBD5 -0.86 -9.8 -0.48 4.72e-20 Breast cancer; CRC cis rs11212617 1.000 rs676729 chr11:108184841 A/G cg14761454 chr11:108092087 ATM;NPAT 0.39 5.7 0.3 2.61e-8 Response to metformin in type 2 diabetes (glycemic); CRC cis rs704795 0.836 rs1647281 chr2:27612938 G/C cg21248554 chr2:27665150 KRTCAP3 -0.31 -7.15 -0.37 5.67e-12 Menopause (age at onset); CRC cis rs17826219 0.714 rs11650821 chr17:28968150 T/C cg19761014 chr17:28927070 LRRC37B2 0.57 5.73 0.3 2.27e-8 Body mass index; CRC cis rs7605827 0.897 rs6431697 chr2:15540034 G/C cg19274914 chr2:15703543 NA 0.4 5.92 0.31 8.18e-9 Educational attainment (years of education); CRC cis rs9398803 0.865 rs9398808 chr6:126758791 G/T cg19875578 chr6:126661172 C6orf173 0.42 5.77 0.3 1.88e-8 Male-pattern baldness; CRC cis rs735396 0.965 rs2257962 chr12:121445808 T/C cg02403541 chr12:121454288 C12orf43 0.43 6.4 0.33 5.27e-10 N-glycan levels; CRC cis rs208520 0.526 rs6455072 chr6:66797215 A/G cg07460842 chr6:66804631 NA -1.17 -25.05 -0.81 3.13e-78 Exhaled nitric oxide output; CRC cis rs9488822 0.636 rs11153592 chr6:116330574 T/C cg18764771 chr6:116381957 FRK 0.25 7.0 0.36 1.45e-11 Cholesterol, total;LDL cholesterol; CRC cis rs2712184 0.660 rs10164732 chr2:217645669 A/T cg05032264 chr2:217675019 NA 0.33 5.8 0.3 1.56e-8 Glomerular filtration rate;Glomerular filtration rate in non diabetics (creatinine); CRC cis rs8060686 0.641 rs16957696 chr16:68039850 C/T cg26727032 chr16:67993705 SLC12A4 -0.56 -6.22 -0.32 1.54e-9 HDL cholesterol;Metabolic syndrome; CRC trans rs16984718 1.000 rs16984718 chr2:18509254 C/T cg15837382 chr1:35332106 DLGAP3 0.59 6.24 0.33 1.34e-9 Urate levels in obese individuals; CRC cis rs447 0.767 rs4732543 chr7:83745910 A/G cg22846510 chr7:83753280 SEMA3A -0.41 -5.67 -0.3 3.21e-8 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs13191362 1.000 rs34653853 chr6:163114362 C/T cg14584255 chr6:163149320 PACRG;PARK2 0.44 6.41 0.33 5e-10 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg21315798 chr22:50354594 PIM3 0.4 6.16 0.32 2.12e-9 Intelligence (multi-trait analysis); CRC cis rs2952156 0.920 rs2517959 chr17:37846512 A/T cg11212589 chr17:38028394 ZPBP2 0.35 5.98 0.31 5.72e-9 Asthma; CRC cis rs10751667 0.961 rs7480178 chr11:927108 T/C ch.11.42038R chr11:967971 AP2A2 0.71 11.92 0.55 1.83e-27 Alzheimer's disease (late onset); CRC cis rs17376456 0.825 rs55947981 chr5:93278104 G/T cg09848695 chr5:92956644 FAM172A;MIR2277 0.67 5.78 0.3 1.76e-8 Diabetic retinopathy; CRC cis rs972578 0.806 rs8140272 chr22:43222242 C/T cg01576275 chr22:43409880 NA -0.43 -6.81 -0.35 4.64e-11 Mean platelet volume; CRC cis rs7772486 0.686 rs4896827 chr6:145953338 T/A cg23711669 chr6:146136114 FBXO30 0.68 11.41 0.53 1.2e-25 Lobe attachment (rater-scored or self-reported); CRC cis rs7945705 0.818 rs2742537 chr11:8908389 G/A cg14711859 chr11:8959438 ASCL3 0.43 7.34 0.38 1.65e-12 Hemoglobin concentration; CRC cis rs904251 0.686 rs2776911 chr6:37439950 T/A cg01843034 chr6:37503916 NA -0.38 -5.68 -0.3 2.91e-8 Cognitive performance; CRC cis rs1150668 0.835 rs1233696 chr6:28143010 T/C cg15845792 chr6:28175446 NA 0.64 9.63 0.47 1.66e-19 Pubertal anthropometrics; CRC cis rs7647973 0.626 rs1352889 chr3:49652148 T/C cg03060546 chr3:49711283 APEH 0.66 8.04 0.41 1.59e-14 Menarche (age at onset); CRC cis rs4925386 0.625 rs3810550 chr20:60912117 C/T cg06026331 chr20:60912101 LAMA5 0.45 5.68 0.3 3.03e-8 Colorectal cancer;Colorectal cancer (SNP x SNP interaction); CRC cis rs10979 1.000 rs11155300 chr6:143894576 A/G cg25407410 chr6:143891975 LOC285740 -0.83 -13.73 -0.6 3.07e-34 Hypospadias; CRC cis rs6060960 0.537 rs75351461 chr20:30458612 C/T cg13852791 chr20:30311386 BCL2L1 0.52 6.86 0.35 3.38e-11 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; CRC cis rs12325245 0.536 rs34161389 chr16:58622604 G/A cg02549819 chr16:58548995 SETD6 1.2 7.97 0.4 2.72e-14 Schizophrenia; CRC trans rs7615952 0.611 rs2947646 chr3:125593602 C/T cg07211511 chr3:129823064 LOC729375 0.95 11.47 0.53 7.47e-26 Blood pressure (smoking interaction); CRC trans rs9825823 0.617 rs2083264 chr3:61074229 A/G cg17403708 chr19:6361531 CLPP 0.42 6.43 0.33 4.61e-10 Depressive symptom measurement or major depressive disorder; CRC trans rs10435719 0.902 rs4840599 chr8:11805380 C/T cg08975724 chr8:8085496 FLJ10661 -0.4 -6.16 -0.32 2.14e-9 C-reactive protein levels or triglyceride levels (pleiotropy); CRC cis rs7727544 0.904 rs58835386 chr5:131600559 A/G cg04518342 chr5:131593106 PDLIM4 0.35 6.49 0.34 3.1e-10 Blood metabolite levels; CRC cis rs4332037 1.000 rs4332037 chr7:1950809 C/T cg25834613 chr7:1915315 MAD1L1 -0.4 -5.88 -0.31 9.96e-9 Bipolar disorder; CRC cis rs8067545 0.586 rs11657161 chr17:20180715 A/G cg13482628 chr17:19912719 NA -0.48 -7.62 -0.39 2.72e-13 Schizophrenia; CRC cis rs2979489 0.891 rs4285443 chr8:30327317 A/G cg26383811 chr8:30366931 RBPMS -0.68 -9.61 -0.47 1.97e-19 Mean corpuscular hemoglobin;Plateletcrit;Neutrophil count;Granulocyte count;Sum basophil neutrophil counts;Mean corpuscular volume;Myeloid white cell count;Sum neutrophil eosinophil counts; CRC cis rs9486719 0.947 rs12208556 chr6:96903486 C/T cg06623918 chr6:96969491 KIAA0776 -0.76 -9.35 -0.46 1.4e-18 Migraine;Coronary artery disease; CRC cis rs11627756 0.957 rs4906236 chr14:103077242 G/A cg12046867 chr14:103022105 NA -0.44 -5.86 -0.31 1.13e-8 Mean platelet volume; CRC cis rs2688608 0.592 rs7923045 chr10:75487498 A/T cg00564723 chr10:75632066 CAMK2G -0.25 -6.17 -0.32 2.06e-9 Inflammatory bowel disease; CRC cis rs4662945 0.699 rs35045564 chr2:130213210 G/A cg05962382 chr2:130345044 NA -0.34 -5.75 -0.3 2.09e-8 Response to cytidine analogues (gemcitabine); CRC cis rs3785888 0.548 rs197923 chr17:45008742 G/C cg16759221 chr17:45003025 GOSR2 -0.69 -10.14 -0.49 3.38e-21 Cleft lip with or without cleft palate; CRC cis rs6951245 1.000 rs77083167 chr7:1071823 C/T cg04025307 chr7:1156635 C7orf50 0.63 6.63 0.34 1.41e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs1997103 1.000 rs10224446 chr7:55413147 C/G cg17469321 chr7:55412551 NA 0.74 11.73 0.54 8.89e-27 QRS interval (sulfonylurea treatment interaction); CRC cis rs13256369 0.802 rs4840350 chr8:8561442 A/G cg17143192 chr8:8559678 CLDN23 0.5 6.44 0.33 4.22e-10 Obesity-related traits; CRC cis rs4665809 0.556 rs4665314 chr2:26415912 T/C cg08067268 chr2:26466485 HADHB;HADHA -0.66 -8.43 -0.42 1.08e-15 Gut microbiome composition (summer); CRC cis rs6952808 0.595 rs3778984 chr7:2166514 T/C cg04267008 chr7:1944627 MAD1L1 -0.69 -9.44 -0.46 7.09e-19 Bipolar disorder and schizophrenia; CRC cis rs877282 0.945 rs11253388 chr10:787852 A/G cg17470449 chr10:769945 NA 0.69 9.03 0.45 1.51e-17 Uric acid levels; CRC trans rs2727020 0.617 rs7102702 chr11:49401125 T/G cg03929089 chr4:120376271 NA -0.81 -11.45 -0.53 9.19e-26 Coronary artery disease; CRC cis rs9325144 0.752 rs12300353 chr12:39154492 G/C cg26384229 chr12:38710491 ALG10B -0.46 -6.17 -0.32 1.98e-9 Morning vs. evening chronotype; CRC cis rs1538970 0.924 rs7531253 chr1:45890183 T/C cg05343316 chr1:45956843 TESK2 0.74 10.05 0.48 6.51e-21 Platelet count; CRC cis rs10504229 0.906 rs58251024 chr8:58172259 G/C cg02290350 chr8:58132656 NA -0.42 -5.96 -0.31 6.62e-9 Developmental language disorder (linguistic errors); CRC cis rs523522 0.962 rs4766969 chr12:120988238 A/G cg27279351 chr12:120934652 DYNLL1 0.77 11.22 0.53 6.06e-25 High light scatter reticulocyte count; CRC cis rs9372498 0.536 rs9489428 chr6:118852935 T/C cg07617317 chr6:118971624 C6orf204 0.5 6.26 0.33 1.22e-9 Diastolic blood pressure; CRC cis rs3767633 0.925 rs1806594 chr1:161858860 T/C cg09175582 chr1:161736000 ATF6 0.7 6.29 0.33 1.03e-9 IgG glycosylation; CRC cis rs7120118 0.517 rs78310113 chr11:47293553 T/G cg25783544 chr11:47291846 MADD 0.62 5.66 0.3 3.36e-8 HDL cholesterol; CRC cis rs4713118 0.955 rs9368529 chr6:27684631 G/A cg12273811 chr6:28175739 NA 0.5 6.93 0.36 2.3e-11 Parkinson's disease; CRC cis rs1059312 0.966 rs12368452 chr12:129277164 C/A cg21616243 chr12:129299702 MGC16384;SLC15A4 -0.65 -10.62 -0.51 7.56e-23 Systemic lupus erythematosus; CRC cis rs6694672 0.867 rs1759006 chr1:197031664 T/C cg13682187 chr1:196946512 CFHR5 0.48 7.49 0.38 6.27e-13 Asthma; CRC cis rs6499255 0.904 rs74029403 chr16:69710472 A/C cg04110750 chr16:69646130 NFAT5 -0.57 -7.45 -0.38 8.06e-13 IgE levels; CRC cis rs3771570 0.901 rs4075818 chr2:242432142 T/C cg21155796 chr2:242212141 HDLBP 0.63 6.8 0.35 5.04e-11 Prostate cancer; CRC cis rs763121 0.853 rs6001184 chr22:39052116 C/T cg06022373 chr22:39101656 GTPBP1 0.78 12.35 0.56 4.64e-29 Menopause (age at onset); CRC cis rs58688157 0.705 rs7122021 chr11:595810 A/G cg01842473 chr11:617407 IRF7;MUPCDH -0.56 -6.66 -0.34 1.18e-10 Systemic lupus erythematosus; CRC cis rs6860806 0.507 rs270608 chr5:131648406 C/T cg11843238 chr5:131593191 PDLIM4 0.46 7.72 0.39 1.45e-13 Breast cancer; CRC cis rs9467603 1.000 rs6902211 chr6:25767437 G/A cg08501292 chr6:25962987 TRIM38 -0.89 -8.08 -0.41 1.23e-14 Intelligence (multi-trait analysis); CRC cis rs6860806 0.695 rs6867282 chr5:131583120 G/C cg09877947 chr5:131593287 PDLIM4 0.47 8.69 0.43 1.71e-16 Breast cancer; CRC cis rs7124681 0.585 rs10838773 chr11:47834346 G/A cg20307385 chr11:47447363 PSMC3 0.46 6.71 0.35 8.61e-11 Body mass index (joint analysis main effects and physical activity interaction);Body mass index;Body mass index in physically active individuals; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg16175725 chr12:121416796 HNF1A 0.25 6.32 0.33 8.27e-10 Intelligence (multi-trait analysis); CRC cis rs6460942 1.000 rs73053531 chr7:12317474 T/C cg06484146 chr7:12443880 VWDE -0.76 -7.52 -0.38 5.36e-13 Coronary artery disease; CRC cis rs7208859 0.673 rs3764421 chr17:29167653 A/C cg01831904 chr17:28903510 LRRC37B2 -0.55 -5.75 -0.3 2.01e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs6951245 0.706 rs28522260 chr7:1183964 C/A cg21664854 chr7:1097933 C7orf50;GPR146 0.7 8.17 0.41 6.73e-15 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs7937682 0.855 rs10891285 chr11:111527775 T/C cg19812747 chr11:111475976 SIK2 -0.57 -9.67 -0.47 1.21e-19 Primary sclerosing cholangitis; CRC cis rs4819052 0.851 rs10470258 chr21:46658989 C/T cg11663144 chr21:46675770 NA -0.83 -14.12 -0.61 9.88e-36 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs929354 0.772 rs6459739 chr7:156998863 A/T cg16102536 chr7:156981717 UBE3C 0.4 6.77 0.35 5.77e-11 Body mass index; CRC cis rs9611565 0.659 rs202653 chr22:41840158 C/T cg06481639 chr22:41940642 POLR3H 0.5 6.09 0.32 3.23e-9 Vitiligo; CRC cis rs1448094 0.511 rs4462416 chr12:86150966 T/C cg18827107 chr12:86230957 RASSF9 0.38 5.92 0.31 8e-9 Major depressive disorder; CRC trans rs2727020 0.576 rs10839305 chr11:49598733 T/C cg11707556 chr5:10655725 ANKRD33B -0.41 -7.72 -0.39 1.4e-13 Coronary artery disease; CRC cis rs780096 0.546 rs4665976 chr2:27640325 A/G cg17158414 chr2:27665306 KRTCAP3 -0.28 -6.23 -0.32 1.46e-9 Total body bone mineral density; CRC cis rs270601 0.710 rs4705852 chr5:131602807 A/G cg02033258 chr5:131593261 PDLIM4 0.46 8.66 0.43 2.08e-16 Acylcarnitine levels; CRC cis rs4481887 0.927 rs4453080 chr1:248474671 T/C cg00666640 chr1:248458726 OR2T12 0.45 7.8 0.4 8.31e-14 Common traits (Other); CRC cis rs847577 0.609 rs17435590 chr7:97784061 T/C cg21770322 chr7:97807741 LMTK2 0.87 19.64 0.73 2.25e-57 Breast cancer; CRC cis rs1707322 1.000 rs7517560 chr1:46425943 A/G cg06784218 chr1:46089804 CCDC17 0.51 9.06 0.45 1.19e-17 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs9916302 0.851 rs6503518 chr17:37660469 A/G cg07936489 chr17:37558343 FBXL20 -0.79 -11.94 -0.55 1.5e-27 Glomerular filtration rate (creatinine); CRC cis rs6912958 0.967 rs9450688 chr6:88159276 T/C cg08069147 chr6:88032118 GJB7;C6orf162 -0.63 -9.54 -0.47 3.38e-19 Monocyte percentage of white cells; CRC cis rs10540 1.000 rs12801271 chr11:508720 C/T cg03934478 chr11:495069 RNH1 0.7 7.84 0.4 6.44e-14 Body mass index; CRC trans rs7647973 0.593 rs7652179 chr3:49808618 T/A cg21665057 chr3:196295764 WDR53;FBXO45 0.59 6.08 0.32 3.35e-9 Menarche (age at onset); CRC cis rs7474896 0.537 rs1022449 chr10:38279467 T/A cg25427524 chr10:38739819 LOC399744 0.59 7.3 0.37 2.14e-12 Obesity (extreme); CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg21224049 chr4:668623 ATP5I -0.52 -6.25 -0.33 1.29e-9 Diisocyanate-induced asthma; CRC cis rs10979 0.597 rs9403516 chr6:143908139 A/T cg25407410 chr6:143891975 LOC285740 0.6 7.87 0.4 5.34e-14 Hypospadias; CRC cis rs10971721 0.822 rs72725378 chr9:33842894 A/G cg13495928 chr9:33750294 PRSS3 0.55 5.9 0.31 9.17e-9 Body mass index; CRC cis rs1448094 0.512 rs12314274 chr12:86249196 A/G cg00310523 chr12:86230176 RASSF9 0.35 5.89 0.31 9.49e-9 Major depressive disorder; CRC cis rs4148883 0.504 rs2000864 chr4:100123776 A/C cg12011299 chr4:100065546 ADH4 0.4 8.81 0.44 7.41e-17 Alcohol dependence; CRC cis rs853679 0.546 rs200981 chr6:27833174 A/G cg06470822 chr6:28175283 NA 0.66 5.66 0.3 3.38e-8 Depression; CRC cis rs7640424 0.589 rs7612356 chr3:107811037 C/G cg09227934 chr3:107805635 CD47 -0.51 -6.43 -0.33 4.55e-10 Body mass index; CRC cis rs4713118 0.869 rs9461405 chr6:27719375 G/T cg12172441 chr6:28176163 NA 0.53 7.29 0.37 2.34e-12 Parkinson's disease; CRC cis rs6087990 0.584 rs6058897 chr20:31398105 G/T cg13636640 chr20:31349939 DNMT3B -0.64 -11.74 -0.54 8.3e-27 Ulcerative colitis; CRC cis rs7119 0.717 rs11639293 chr15:77810845 T/C cg10437265 chr15:77819839 NA 0.69 12.75 0.57 1.62e-30 Type 2 diabetes; CRC cis rs9322193 0.923 rs2297928 chr6:150039720 G/C cg13206674 chr6:150067644 NUP43 0.65 9.76 0.47 6.08e-20 Lung cancer; CRC cis rs6502050 0.769 rs9898542 chr17:80119682 C/T cg02741985 chr17:80059408 CCDC57 0.43 7.15 0.37 5.59e-12 Life satisfaction; CRC cis rs6570726 0.755 rs451699 chr6:145830594 C/G cg05347473 chr6:146136440 FBXO30 0.4 6.23 0.32 1.45e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs7666738 0.830 rs10028505 chr4:98962310 C/A cg05340658 chr4:99064831 C4orf37 0.61 9.45 0.46 6.55e-19 Colonoscopy-negative controls vs population controls; CRC cis rs60843830 0.550 rs300751 chr2:209063 A/C cg25945732 chr2:264204 ACP1;SH3YL1 0.51 7.8 0.4 8.14e-14 Spherical equivalent (joint analysis main effects and education interaction); CRC cis rs8060686 0.641 rs111227007 chr16:68093138 T/A cg26727032 chr16:67993705 SLC12A4 -0.55 -6.49 -0.34 3.16e-10 HDL cholesterol;Metabolic syndrome; CRC trans rs7618501 0.633 rs4688757 chr3:50035323 T/C cg21665057 chr3:196295764 WDR53;FBXO45 0.61 9.77 0.47 5.59e-20 Intelligence (multi-trait analysis); CRC cis rs9733 0.519 rs72704603 chr1:150707992 C/T cg10589385 chr1:150898437 SETDB1 0.3 6.42 0.33 4.76e-10 Tonsillectomy; CRC cis rs2721195 1.000 rs11542372 chr8:145677089 G/A cg15320075 chr8:145703422 NA -0.65 -10.9 -0.52 7.91e-24 Age at first birth; CRC trans rs877282 0.898 rs36064821 chr10:760952 C/T cg22713356 chr15:30763199 NA 1.24 14.66 0.63 8.4e-38 Uric acid levels; CRC cis rs4665809 0.838 rs7565843 chr2:26292912 G/C cg04944784 chr2:26401820 FAM59B -0.6 -7.69 -0.39 1.76e-13 Gut microbiome composition (summer); CRC cis rs1799949 1.000 rs8176133 chr17:41257458 A/C cg01879757 chr17:41196368 BRCA1 -0.41 -6.15 -0.32 2.24e-9 Menopause (age at onset); CRC cis rs1577917 0.958 rs12205492 chr6:86475976 A/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.62 -7.88 -0.4 4.85e-14 Response to antipsychotic treatment; CRC cis rs7927592 0.956 rs10896334 chr11:68281494 C/T cg16797656 chr11:68205561 LRP5 0.36 5.65 0.3 3.46e-8 Total body bone mineral density; CRC trans rs2018683 0.707 rs1021690 chr7:28974488 A/G cg19402173 chr7:128379420 CALU -0.43 -6.3 -0.33 9.74e-10 Response to irinotecan and platinum-based chemotherapy in non-small-cell lung cancer; CRC cis rs9914988 0.832 rs35033748 chr17:27179590 T/C cg12682573 chr17:27188876 MIR451;MIR144 0.59 8.53 0.43 5.4e-16 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs394563 1.000 rs394563 chr6:149797014 T/G cg03678062 chr6:149772716 ZC3H12D -0.35 -6.15 -0.32 2.26e-9 Dupuytren's disease; CRC cis rs7647973 1.000 rs9860055 chr3:49506900 C/T cg20833759 chr3:49053208 WDR6;DALRD3 -0.55 -8.02 -0.4 1.91e-14 Menarche (age at onset); CRC cis rs4319547 0.508 rs10846826 chr12:122894987 C/T cg23029597 chr12:123009494 RSRC2 -0.56 -6.95 -0.36 1.97e-11 Body mass index; CRC cis rs6951245 0.935 rs79143504 chr7:1110212 A/G cg04025307 chr7:1156635 C7orf50 0.66 6.85 0.35 3.6e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs597539 0.652 rs514833 chr11:68657734 C/T cg06028808 chr11:68637592 NA 0.4 6.34 0.33 7.42e-10 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs2991971 0.782 rs10789463 chr1:45927848 C/A cg24296786 chr1:45957014 TESK2 -0.48 -7.1 -0.36 7.96e-12 High light scatter reticulocyte count; CRC cis rs4689592 0.587 rs6825954 chr4:7074226 T/C cg19539972 chr4:7069911 GRPEL1 0.78 9.79 0.47 5.11e-20 Monocyte percentage of white cells; CRC cis rs75920871 0.588 rs4548653 chr11:116903316 G/A cg01368799 chr11:117014884 PAFAH1B2 -0.42 -5.93 -0.31 7.46e-9 Subjective well-being; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg19740361 chr19:45596828 NA 0.45 7.35 0.38 1.53e-12 Liver disease severity in Alagille syndrome; CRC cis rs11645898 0.810 rs72787085 chr16:72182564 C/T cg14768367 chr16:72042858 DHODH -0.6 -6.74 -0.35 7.24e-11 Blood protein levels; CRC cis rs10751667 0.600 rs10751672 chr11:948712 T/C cg23136738 chr11:925521 AP2A2 -0.4 -6.56 -0.34 2.04e-10 Alzheimer's disease (late onset); CRC cis rs1801251 0.896 rs2305141 chr2:233684402 A/G cg25237894 chr2:233734115 C2orf82 -0.45 -6.94 -0.36 2.1e-11 Coronary artery disease; CRC cis rs6844506 1.000 rs35067299 chr4:185218513 T/C cg18317788 chr4:185205197 NA -0.43 -6.02 -0.32 4.55e-9 Gestational age at birth in premature rupture of membrane-initiated deliveries (child effect); CRC cis rs7917772 0.636 rs7911747 chr10:104528890 A/G cg11453585 chr10:104263688 ACTR1A;SUFU -0.68 -10.16 -0.49 2.94e-21 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC trans rs2243480 1.000 rs7795242 chr7:65390094 T/C cg10756647 chr7:56101905 PSPH 0.73 8.07 0.41 1.36e-14 Diabetic kidney disease; CRC cis rs6460942 0.555 rs7803268 chr7:12306793 G/A cg06484146 chr7:12443880 VWDE -0.71 -7.26 -0.37 2.84e-12 Coronary artery disease; CRC cis rs7666738 0.830 rs9995386 chr4:98907826 T/C cg17366294 chr4:99064904 C4orf37 0.42 6.93 0.36 2.24e-11 Colonoscopy-negative controls vs population controls; CRC cis rs7552404 0.727 rs5745390 chr1:76306591 A/C cg10523679 chr1:76189770 ACADM 0.73 9.51 0.46 4.24e-19 Blood metabolite levels;Acylcarnitine levels; CRC trans rs1814175 0.817 rs7483795 chr11:49704930 G/A cg11707556 chr5:10655725 ANKRD33B -0.42 -7.89 -0.4 4.66e-14 Height; CRC cis rs853679 0.517 rs9368555 chr6:28108967 T/C cg02683197 chr6:28174875 NA 0.87 10.73 0.51 3.25e-23 Depression; CRC trans rs62295889 0.602 rs55646236 chr4:12538095 C/T cg03490839 chr16:73082051 ZFHX3 0.58 6.06 0.32 3.82e-9 Obesity-related traits; CRC cis rs728616 0.867 rs61860039 chr10:81939906 G/A cg05935833 chr10:81318306 SFTPA2 -0.72 -7.91 -0.4 3.91e-14 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs4363385 0.818 rs574649 chr1:153008471 G/A cg25856811 chr1:152973957 SPRR3 -0.25 -6.99 -0.36 1.51e-11 Inflammatory skin disease; CRC cis rs999943 0.846 rs9366826 chr6:33619184 C/G cg14003231 chr6:33640908 ITPR3 0.89 16.03 0.66 3.7e-43 Obesity (extreme); CRC trans rs916888 0.821 rs199513 chr17:44856932 A/G cg22968622 chr17:43663579 NA -1.08 -14.05 -0.61 1.92e-35 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs9322193 0.962 rs2151912 chr6:150152908 A/G cg13206674 chr6:150067644 NUP43 0.56 7.93 0.4 3.5e-14 Lung cancer; CRC cis rs4731207 0.698 rs7794710 chr7:124561115 C/G cg23710748 chr7:124431027 NA -0.37 -5.99 -0.31 5.5e-9 Cutaneous malignant melanoma; CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg27649522 chr12:12877729 APOLD1 -0.52 -6.42 -0.33 4.87e-10 Diisocyanate-induced asthma; CRC cis rs1568889 1.000 rs7951681 chr11:28273894 G/C cg06544937 chr11:28130018 METT5D1;KIF18A 0.78 11.11 0.52 1.49e-24 Bipolar disorder; CRC cis rs2718058 0.692 rs2718041 chr7:37783944 A/G cg24998770 chr7:37888106 TXNDC3 0.37 6.09 0.32 3.08e-9 Alzheimer's disease (late onset); CRC cis rs853679 0.517 rs9357063 chr6:28060005 G/A cg23161317 chr6:28129485 ZNF389 0.52 6.36 0.33 6.59e-10 Depression; CRC cis rs644799 1.000 rs12786522 chr11:95522858 G/C cg03916912 chr11:95522834 CEP57;FAM76B 0.95 18.12 0.71 2.28e-51 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs3008870 0.755 rs1925409 chr1:67365089 C/T cg08660285 chr1:67390436 MIER1;WDR78 -0.53 -7.41 -0.38 1.04e-12 Lymphocyte percentage of white cells; CRC cis rs713587 0.967 rs6749422 chr2:25150011 C/G cg04586622 chr2:25135609 ADCY3 -0.45 -8.04 -0.41 1.61e-14 Body mass index in non-asthmatics; CRC cis rs2012796 1.000 rs12436146 chr14:81821282 A/G cg02996355 chr14:81879375 NA 0.5 7.35 0.38 1.6e-12 Night sleep phenotypes; CRC cis rs10256972 0.721 rs2030959 chr7:1075906 T/C cg03188948 chr7:1209495 NA 0.41 6.04 0.32 4.14e-9 Longevity;Endometriosis; CRC cis rs780096 0.565 rs780104 chr2:27677691 G/A cg22903471 chr2:27725779 GCKR -0.37 -6.06 -0.32 3.65e-9 Total body bone mineral density; CRC cis rs1564271 0.506 rs1148163 chr10:26929671 G/C cg13837822 chr10:26931731 LOC731789 0.7 10.95 0.52 5.42e-24 Overall survival in serous epithelial ovarian cancer treated with paclitaxel and cisplatin; CRC cis rs7072216 0.687 rs4551689 chr10:100157593 C/T cg26618903 chr10:100175079 PYROXD2 0.34 5.61 0.3 4.37e-8 Metabolite levels; CRC cis rs4700695 0.686 rs37236 chr5:65223730 C/G cg21114390 chr5:65439923 SFRS12 0.59 6.38 0.33 5.92e-10 Facial morphology (factor 19); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg17324707 chr3:122103153 FAM162A;CCDC58 0.52 7.51 0.38 5.72e-13 Response to antipsychotic treatment; CRC cis rs7647973 1.000 rs9860055 chr3:49506900 C/T cg07636037 chr3:49044803 WDR6 -0.65 -7.65 -0.39 2.18e-13 Menarche (age at onset); CRC cis rs908922 0.676 rs528427 chr1:152511507 G/C cg23254163 chr1:152506842 NA 0.45 8.85 0.44 5.3e-17 Hair morphology; CRC cis rs763014 0.966 rs12935215 chr16:670605 T/C cg04497992 chr16:616212 NHLRC4 0.44 6.96 0.36 1.84e-11 Height; CRC cis rs1559088 0.948 rs9304844 chr19:33579935 G/T cg27124370 chr19:33622961 WDR88 0.45 6.19 0.32 1.74e-9 Bone ultrasound measurement (broadband ultrasound attenuation); CRC trans rs2727020 0.553 rs61904166 chr11:49581461 T/C cg15704280 chr7:45808275 SEPT13 -0.94 -17.3 -0.69 3.78e-48 Coronary artery disease; CRC cis rs853679 0.517 rs4713143 chr6:28106759 A/C cg15786705 chr6:28176104 NA 0.77 9.75 0.47 6.92e-20 Depression; CRC cis rs7660520 0.557 rs76004373 chr4:183731011 C/G cg12483801 chr4:183727862 NA 0.65 8.16 0.41 7.37e-15 Pediatric autoimmune diseases; CRC cis rs7086627 0.515 rs12245180 chr10:82211897 C/G cg00277334 chr10:82204260 NA -0.84 -16.95 -0.68 9.58e-47 Post bronchodilator FEV1; CRC cis rs10927875 0.722 rs945425 chr1:16348412 T/C cg22431228 chr1:16359049 CLCNKA -0.44 -7.73 -0.39 1.35e-13 Dilated cardiomyopathy; CRC cis rs10911232 0.507 rs10911198 chr1:182997318 G/T ch.1.3577855R chr1:183094577 LAMC1 0.86 15.15 0.64 1.1e-39 Hypertriglyceridemia; CRC cis rs60843830 0.661 rs7588043 chr2:104979 C/T cg25945732 chr2:264204 ACP1;SH3YL1 0.46 6.39 0.33 5.56e-10 Spherical equivalent (joint analysis main effects and education interaction); CRC cis rs6121246 0.559 rs6058468 chr20:30406448 C/A cg13852791 chr20:30311386 BCL2L1 0.8 15.88 0.66 1.49e-42 Mean corpuscular hemoglobin; CRC cis rs478304 0.654 rs12289836 chr11:65436888 C/T cg05805236 chr11:65401703 PCNXL3 0.38 5.91 0.31 8.55e-9 Acne (severe); CRC cis rs4819052 0.819 rs7279136 chr21:46692287 C/T cg02159808 chr21:46707872 POFUT2;LOC642852 0.51 6.72 0.35 8.21e-11 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs2832191 0.692 rs2254872 chr21:30414724 C/T cg24692254 chr21:30365293 RNF160 0.86 16.23 0.67 6.18e-44 Dental caries; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg24106215 chr1:202927166 ADIPOR1 0.47 6.01 0.31 5.06e-9 Thyroid stimulating hormone; CRC cis rs977987 0.843 rs12443834 chr16:75438469 C/T cg03315344 chr16:75512273 CHST6 0.54 9.08 0.45 1.01e-17 Dupuytren's disease; CRC cis rs6662572 0.737 rs111970066 chr1:46572817 C/T cg08644498 chr1:46502608 NA 0.46 7.36 0.38 1.45e-12 Blood protein levels; CRC cis rs8077889 0.917 rs9901676 chr17:41911818 T/C cg26893861 chr17:41843967 DUSP3 0.9 13.01 0.58 1.6e-31 Triglycerides; CRC trans rs4263408 0.934 rs9683743 chr4:39703194 A/C cg05524038 chr5:149493258 CSF1R -0.4 -6.51 -0.34 2.75e-10 Plasma amyloid beta peptide concentrations (ABx-40); CRC trans rs11343 0.675 rs7359333 chr16:19262344 A/T cg06601766 chr17:61851465 DDX42;CCDC47 -0.49 -6.13 -0.32 2.47e-9 Parkinson's disease; CRC cis rs2797160 1.000 rs1954361 chr6:126001423 C/G cg05901451 chr6:126070800 HEY2 -0.4 -6.17 -0.32 2.01e-9 Endometrial cancer; CRC cis rs6534441 0.727 rs6534443 chr4:125425698 C/T cg21609808 chr4:125404261 NA 0.39 5.64 0.3 3.67e-8 Major depressive disorder; CRC cis rs3749237 0.595 rs4855859 chr3:49526300 C/T cg07636037 chr3:49044803 WDR6 0.56 8.03 0.4 1.72e-14 Resting heart rate; CRC cis rs7769051 1.000 rs9493438 chr6:133098349 T/C cg07930552 chr6:133119739 C6orf192 0.59 7.01 0.36 1.33e-11 Type 2 diabetes nephropathy; CRC trans rs459482 1.000 rs459498 chr21:42795027 G/A cg24154722 chr2:241858322 NA 0.34 6.05 0.32 4.04e-9 IgG glycosylation; CRC cis rs4737010 0.501 rs1579274 chr8:41658923 T/G cg17182837 chr8:41585554 ANK1 -0.48 -6.2 -0.32 1.71e-9 Lymphocyte counts;High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Reticulocyte count;Reticulocyte fraction of red cells;Mean corpuscular volume;Immature fraction of reticulocytes;Mean corpuscular hemoglobin concentration; CRC cis rs7301826 0.627 rs4325342 chr12:131312482 G/A cg11011512 chr12:131303247 STX2 0.38 5.7 0.3 2.7e-8 Plasma plasminogen activator levels; CRC cis rs6969780 1.000 rs929249 chr7:27167537 T/C cg26364809 chr7:27145159 NA -0.72 -6.66 -0.34 1.15e-10 Diastolic blood pressure;Blood pressure traits (multi-trait analysis);Systolic blood pressure;Hypertension; CRC cis rs2404602 0.583 rs12592501 chr15:76554790 C/A cg22467129 chr15:76604101 ETFA -0.48 -8.57 -0.43 3.96e-16 Blood metabolite levels; CRC cis rs2115536 1.000 rs11072871 chr15:80197931 T/C cg00225070 chr15:80189496 MTHFS 0.49 7.84 0.4 6.2e-14 Eosinophil counts;Eosinophil percentage of white cells;Sum eosinophil basophil counts;Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; CRC cis rs3617 0.522 rs6773650 chr3:52897095 A/T cg07507251 chr3:52567010 NT5DC2 0.4 5.98 0.31 5.83e-9 Red blood cell count;Autism spectrum disorder or schizophrenia; CRC cis rs4727963 0.765 rs1525470 chr7:122733854 T/C cg03640110 chr7:122635026 TAS2R16 0.35 6.33 0.33 8.19e-10 Adverse response to chemotherapy (neutropenia/leucopenia) (docetaxel); CRC cis rs10504229 1.000 rs17217033 chr8:58180061 G/T cg02290350 chr8:58132656 NA -0.42 -5.96 -0.31 6.62e-9 Developmental language disorder (linguistic errors); CRC cis rs2295359 0.892 rs10889657 chr1:67615487 A/G cg17031739 chr1:67600172 NA 0.44 6.96 0.36 1.84e-11 Psoriasis; CRC trans rs2303319 0.504 rs12467613 chr2:162603216 G/T cg18122310 chr12:50236657 BCDIN3D -0.73 -6.35 -0.33 7.23e-10 Cognitive function; CRC cis rs3815700 1.000 rs7247420 chr19:33096786 G/A cg02997394 chr19:33096574 ANKRD27 0.77 8.82 0.44 6.96e-17 Eosinophilic esophagitis; CRC cis rs7809950 1.000 rs3801948 chr7:107238447 A/T cg23024343 chr7:107201750 COG5 -0.61 -8.81 -0.44 7.12e-17 Coronary artery disease; CRC cis rs9894429 0.716 rs7405578 chr17:79588306 C/A cg18240062 chr17:79603768 NPLOC4 0.66 11.73 0.54 8.46e-27 Eye color traits; CRC trans rs66573146 0.831 rs56320732 chr4:6974319 G/A cg07817883 chr1:32538562 TMEM39B 1.35 12.74 0.57 1.69e-30 Granulocyte percentage of myeloid white cells; CRC cis rs13108904 0.905 rs1680074 chr4:1279621 G/A cg16405210 chr4:1374714 KIAA1530 0.44 6.5 0.34 3.01e-10 Obesity-related traits; CRC cis rs1403694 0.695 rs1851664 chr3:186436503 T/A cg04611788 chr3:186434169 KNG1 -0.58 -8.7 -0.43 1.67e-16 Blood protein levels; CRC cis rs8141529 0.764 rs5762824 chr22:29222930 C/T cg15103426 chr22:29168792 CCDC117 0.58 8.44 0.42 1.04e-15 Lymphocyte counts; CRC cis rs1552244 1.000 rs17032268 chr3:10067972 C/T cg10729496 chr3:10149963 C3orf24 0.5 6.71 0.35 8.29e-11 Alzheimer's disease; CRC cis rs7927771 0.832 rs6485753 chr11:47410200 C/T cg20307385 chr11:47447363 PSMC3 0.65 9.47 0.46 5.59e-19 Subjective well-being; CRC cis rs6964587 0.967 rs7781221 chr7:91664645 A/G cg17063962 chr7:91808500 NA 0.8 14.15 0.62 7.64e-36 Breast cancer; CRC cis rs56399783 0.901 rs73051444 chr7:2866529 G/A cg19731401 chr7:2775893 GNA12 0.56 5.9 0.31 8.84e-9 Childhood ear infection; CRC cis rs1153858 0.943 rs8038342 chr15:45651537 T/C cg14582100 chr15:45693742 SPATA5L1 0.29 6.11 0.32 2.89e-9 Homoarginine levels; CRC cis rs2735413 0.709 rs1319049 chr16:78084610 T/G cg04733911 chr16:78082701 NA 0.42 6.59 0.34 1.77e-10 Systolic blood pressure (alcohol consumption interaction); CRC cis rs951366 0.789 rs823137 chr1:205738302 C/T cg11965913 chr1:205819406 PM20D1 0.83 13.65 0.6 6.2e-34 Menarche (age at onset); CRC cis rs1552244 1.000 rs6804473 chr3:10060425 C/T cg08888203 chr3:10149979 C3orf24 0.69 9.65 0.47 1.4e-19 Alzheimer's disease; CRC cis rs2839186 0.609 rs2839189 chr21:47694357 C/T cg12516959 chr21:47718080 NA 0.47 7.83 0.4 6.9e-14 Testicular germ cell tumor; CRC cis rs9322193 0.923 rs62441303 chr6:150088683 A/G cg07701084 chr6:150067640 NUP43 0.46 6.49 0.34 3.1e-10 Lung cancer; CRC cis rs951366 0.617 rs708727 chr1:205767885 G/A cg24503407 chr1:205819492 PM20D1 1.01 18.25 0.71 6.98e-52 Menarche (age at onset); CRC cis rs780096 0.546 rs2911712 chr2:27626945 A/T cg27432699 chr2:27873401 GPN1 -0.51 -7.71 -0.39 1.49e-13 Total body bone mineral density; CRC cis rs116095464 0.558 rs61492827 chr5:225774 A/G cg22496380 chr5:211416 CCDC127 -0.84 -9.73 -0.47 7.72e-20 Breast cancer; CRC cis rs4713118 0.516 rs6931858 chr6:28078411 A/T cg02683197 chr6:28174875 NA 0.79 9.52 0.46 3.93e-19 Parkinson's disease; CRC cis rs812925 0.519 rs967968 chr2:61656056 C/G cg10580144 chr2:61372316 C2orf74 -0.31 -6.59 -0.34 1.76e-10 Immature fraction of reticulocytes; CRC cis rs2836974 0.555 rs35909862 chr21:40621158 G/A cg11890956 chr21:40555474 PSMG1 -0.91 -15.63 -0.65 1.46e-41 Cognitive function; CRC cis rs6968419 0.674 rs4730724 chr7:115905339 A/G cg02561103 chr7:115862891 TES -0.43 -6.5 -0.34 2.92e-10 Intraocular pressure; CRC cis rs9322193 0.923 rs12174349 chr6:150039148 G/A cg07701084 chr6:150067640 NUP43 0.56 8.31 0.42 2.47e-15 Lung cancer; CRC cis rs34779708 0.897 rs7897827 chr10:35386237 C/T cg03585969 chr10:35415529 CREM 0.6 8.04 0.41 1.63e-14 Inflammatory bowel disease;Crohn's disease; CRC cis rs12580194 0.593 rs59136392 chr12:55748204 C/T cg19537932 chr12:55886519 OR6C68 -0.66 -8.56 -0.43 4.26e-16 Cancer; CRC trans rs2303319 0.504 rs961421 chr2:162626099 G/C cg12500891 chr11:57225987 NA -0.65 -6.05 -0.32 3.87e-9 Cognitive function; CRC cis rs6540559 1.000 rs2235372 chr1:209960436 A/G cg21951975 chr1:209979733 IRF6 -0.47 -6.86 -0.35 3.34e-11 Cleft lip with or without cleft palate; CRC cis rs2839186 0.934 rs2839194 chr21:47699437 T/G cg09417038 chr21:47716443 C21orf57 -0.42 -6.93 -0.36 2.19e-11 Testicular germ cell tumor; CRC cis rs3785574 0.924 rs2727292 chr17:61893747 A/G cg06601766 chr17:61851465 DDX42;CCDC47 0.6 8.45 0.42 9.3e-16 Height; CRC cis rs7654585 0.645 rs1123943 chr4:25924426 A/G cg10409131 chr4:25915609 C4orf52 -0.51 -7.18 -0.37 4.79e-12 Obesity-related traits; CRC cis rs9491140 0.539 rs11154221 chr6:124675246 C/T cg19267163 chr6:125004984 NKAIN2 0.44 5.96 0.31 6.33e-9 Neuroticism; CRC cis rs2635047 0.682 rs7242976 chr18:44797159 T/A cg19077165 chr18:44547161 KATNAL2 -0.39 -5.99 -0.31 5.6e-9 Educational attainment; CRC cis rs7546094 1.000 rs7554916 chr1:113123734 A/C cg22162597 chr1:113214053 CAPZA1 0.43 6.08 0.32 3.27e-9 Platelet distribution width; CRC cis rs4838594 0.563 rs4838597 chr10:49679397 G/A cg17291251 chr10:49678358 ARHGAP22 0.46 7.25 0.37 2.92e-12 Daytime sleep phenotypes; CRC cis rs10463316 0.894 rs11167542 chr5:150760282 A/G cg03212797 chr5:150827313 SLC36A1 0.52 7.9 0.4 4.23e-14 Metabolite levels (Pyroglutamine); CRC cis rs4969178 0.931 rs3826323 chr17:76400268 C/G cg05887092 chr17:76393375 PGS1 0.56 10.01 0.48 9.4e-21 HDL cholesterol levels; CRC cis rs1336900 0.637 rs35967040 chr1:150555588 A/C cg18016565 chr1:150552671 MCL1 -0.52 -7.73 -0.39 1.36e-13 Blood protein levels; CRC cis rs10504229 1.000 rs79561699 chr8:58170601 A/G cg24829409 chr8:58192753 C8orf71 -0.67 -11.39 -0.53 1.41e-25 Developmental language disorder (linguistic errors); CRC cis rs7044106 0.690 rs10739569 chr9:123361027 C/G cg09586646 chr9:123605570 PSMD5;LOC253039 0.47 6.7 0.35 8.95e-11 Hip circumference adjusted for BMI; CRC trans rs12599106 0.839 rs3853177 chr16:34498532 A/G cg15383120 chr6:291909 DUSP22 -0.51 -7.13 -0.37 6.29e-12 Menopause (age at onset); CRC cis rs11098699 0.821 rs11939262 chr4:124207018 A/G cg09941581 chr4:124220074 SPATA5 0.4 5.87 0.31 1.08e-8 Mosquito bite size; CRC cis rs9368481 0.502 rs3933232 chr6:26877446 T/C cg05192639 chr6:26864778 GUSBL1 0.33 5.9 0.31 8.99e-9 Autism spectrum disorder or schizophrenia; CRC cis rs7091957 1.000 rs7091957 chr10:134439478 C/T cg27286337 chr10:134555280 INPP5A 0.47 7.04 0.36 1.09e-11 Gait speed in old age; CRC cis rs13108904 0.901 rs13124847 chr4:1278206 A/G cg00684032 chr4:1343700 KIAA1530 0.49 7.25 0.37 3.04e-12 Obesity-related traits; CRC cis rs13031619 0.607 rs13011199 chr2:3694994 A/G cg19052272 chr2:3704530 ALLC 0.43 6.28 0.33 1.05e-9 Response to inhaled corticosteroid treatment in asthma (change in FEV1); CRC cis rs908922 0.676 rs478926 chr1:152511533 G/T cg09873164 chr1:152488093 CRCT1 0.38 6.4 0.33 5.37e-10 Hair morphology; CRC cis rs2811415 0.597 rs9813438 chr3:127797796 C/G cg13719885 chr3:127795394 NA -0.4 -5.99 -0.31 5.51e-9 Lung function (FEV1/FVC); CRC cis rs7772486 0.686 rs4896833 chr6:145965673 T/G cg13319975 chr6:146136371 FBXO30 -0.4 -5.94 -0.31 7.41e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs78456975 1.000 rs13416881 chr2:1554808 G/A cg01028140 chr2:1542097 TPO -0.56 -5.73 -0.3 2.25e-8 Placebo response in major depressive disorder (% change in symptom score); CRC cis rs9611565 0.649 rs202614 chr22:41822150 A/C cg03806693 chr22:41940476 POLR3H 1.1 13.52 0.6 1.95e-33 Vitiligo; CRC cis rs6912958 0.500 rs4706287 chr6:87806496 A/G cg08069147 chr6:88032118 GJB7;C6orf162 -0.62 -8.96 -0.44 2.41e-17 Monocyte percentage of white cells; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg22263405 chr18:42259244 SETBP1 0.37 6.34 0.33 7.38e-10 Liver disease severity in Alagille syndrome; CRC cis rs7727544 0.506 rs10040809 chr5:131343017 A/C cg18758796 chr5:131593413 PDLIM4 0.32 5.64 0.3 3.58e-8 Blood metabolite levels; CRC cis rs11122272 0.735 rs2808586 chr1:231515559 C/T cg06096015 chr1:231504339 EGLN1 0.4 5.95 0.31 6.7e-9 Hemoglobin concentration; CRC trans rs10506458 0.915 rs12424908 chr12:63402364 G/A cg03429785 chr15:59498649 MYO1E;LDHAL6B -1.41 -20.81 -0.75 5.94e-62 Hemostatic factors and hematological phenotypes; CRC cis rs561341 0.609 rs739800 chr17:30190083 T/A cg00745463 chr17:30367425 LRRC37B 0.54 6.64 0.34 1.34e-10 Hip circumference adjusted for BMI; CRC cis rs8078723 0.714 rs8070444 chr17:38151960 A/G cg17344932 chr17:38183730 MED24;SNORD124 0.48 7.98 0.4 2.38e-14 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg14821008 chr6:64283529 PTP4A1 0.46 6.66 0.34 1.14e-10 Intelligence (multi-trait analysis); CRC trans rs9329221 0.527 rs34308302 chr8:10332022 C/T cg06636001 chr8:8085503 FLJ10661 -0.5 -7.44 -0.38 9.06e-13 Neuroticism; CRC cis rs7927771 1.000 rs9909 chr11:47799775 C/G cg05585544 chr11:47624801 NA -0.62 -10.82 -0.51 1.47e-23 Subjective well-being; CRC cis rs4073582 0.595 rs801739 chr11:65922589 A/G cg16950941 chr11:66035639 RAB1B 0.67 11.55 0.54 3.94e-26 Gout; CRC cis rs2832191 0.646 rs2832210 chr21:30508723 T/G cg24692254 chr21:30365293 RNF160 -0.58 -8.43 -0.42 1.12e-15 Dental caries; CRC cis rs561341 0.700 rs8079471 chr17:30218317 A/G cg13647721 chr17:30228624 UTP6 0.61 7.96 0.4 2.84e-14 Hip circumference adjusted for BMI; CRC cis rs7587476 0.784 rs13026390 chr2:215687075 C/T cg04004882 chr2:215674386 BARD1 -0.65 -9.3 -0.46 2.06e-18 Neuroblastoma; CRC cis rs7666738 0.830 rs34244876 chr4:99031336 G/A cg05340658 chr4:99064831 C4orf37 0.61 9.42 0.46 8.23e-19 Colonoscopy-negative controls vs population controls; CRC trans rs9329221 0.532 rs2062333 chr8:9981149 A/G cg06636001 chr8:8085503 FLJ10661 0.46 6.71 0.35 8.35e-11 Neuroticism; CRC cis rs4805272 0.539 rs7256211 chr19:29333063 C/G cg12756686 chr19:29218302 NA 0.45 6.32 0.33 8.59e-10 Plasma omega-3 polyunsaturated fatty acid levels (docosahexaenoic acid); CRC cis rs9297145 0.565 rs12705030 chr7:98765041 A/G cg05967295 chr7:98741636 SMURF1 -0.63 -9.99 -0.48 1.1e-20 Crohn's disease;Inflammatory bowel disease;Ulcerative colitis; CRC cis rs4666002 0.956 rs4665383 chr2:27791555 C/G cg27432699 chr2:27873401 GPN1 0.45 5.66 0.3 3.3e-8 Phospholipid levels (plasma); CRC cis rs12586317 0.513 rs74564132 chr14:35472882 C/T cg05294307 chr14:35346193 BAZ1A -0.72 -7.89 -0.4 4.61e-14 Psoriasis; CRC cis rs7429990 0.901 rs7433678 chr3:48037078 G/A cg11946769 chr3:48343235 NME6 -0.45 -5.82 -0.31 1.43e-8 Educational attainment (years of education); CRC cis rs10504229 0.683 rs66730544 chr8:58127280 A/T cg05313129 chr8:58192883 C8orf71 -0.43 -6.11 -0.32 2.74e-9 Developmental language disorder (linguistic errors); CRC cis rs9311676 0.656 rs55727087 chr3:58404547 G/A cg06643156 chr3:58380774 PXK 0.42 6.38 0.33 5.84e-10 Systemic lupus erythematosus; CRC cis rs17767392 1.000 rs34057981 chr14:71823981 T/G cg13720639 chr14:72061746 SIPA1L1 -0.54 -6.77 -0.35 5.81e-11 Mitral valve prolapse; CRC cis rs6951245 0.935 rs113365567 chr7:1108785 T/C cg20603222 chr7:1096387 C7orf50;GPR146 -0.73 -8.71 -0.43 1.53e-16 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg18728699 chr15:90931313 IQGAP1 0.5 7.09 0.36 8.25e-12 Response to antipsychotic treatment; CRC cis rs972578 0.836 rs5759021 chr22:43301900 A/C cg01576275 chr22:43409880 NA -0.4 -6.27 -0.33 1.13e-9 Mean platelet volume; CRC cis rs7209700 0.742 rs999323 chr17:45371603 T/C cg08085267 chr17:45401833 C17orf57 0.41 5.78 0.3 1.77e-8 IgG glycosylation; CRC cis rs12368653 0.693 rs2640610 chr12:58037435 T/A cg15848620 chr12:58087721 OS9 -0.42 -5.85 -0.31 1.16e-8 Multiple sclerosis; CRC cis rs9814567 0.929 rs13316205 chr3:134223563 G/A cg06541857 chr3:134203789 ANAPC13;CEP63 -0.4 -6.03 -0.32 4.53e-9 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC trans rs4942242 0.663 rs34978818 chr13:44214096 T/C cg27382691 chr15:76552771 ETFA;TYRO3P -0.48 -6.33 -0.33 8.24e-10 Response to tocilizumab in rheumatoid arthritis; CRC cis rs7937682 0.889 rs1940529 chr11:111498523 G/C cg19812747 chr11:111475976 SIK2 -0.59 -10.03 -0.48 7.56e-21 Primary sclerosing cholangitis; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg09537173 chr15:85144474 ZSCAN2 0.43 6.16 0.32 2.17e-9 Intelligence (multi-trait analysis); CRC cis rs4076764 0.801 rs6698738 chr1:163359918 G/A cg06092702 chr1:163392909 NA -0.52 -8.18 -0.41 6.42e-15 Motion sickness; CRC cis rs919433 0.783 rs2565158 chr2:198236103 T/A cg03934865 chr2:198174659 NA 0.36 5.82 0.31 1.42e-8 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC cis rs1865760 0.566 rs2051544 chr6:26071093 C/T cg16482183 chr6:26056742 HIST1H1C 0.52 7.56 0.38 4.16e-13 Height; CRC cis rs34172651 0.517 rs200528 chr16:24759131 A/G cg00339695 chr16:24857497 SLC5A11 -0.44 -9.24 -0.45 3.21e-18 Intelligence (multi-trait analysis); CRC cis rs7215564 0.908 rs36100789 chr17:78701117 C/T cg09596252 chr17:78655493 RPTOR 0.61 6.5 0.34 2.92e-10 Myopia (pathological); CRC cis rs644799 1.000 rs617999 chr11:95589935 A/G cg25622487 chr11:95524042 FAM76B;CEP57 0.76 11.8 0.55 4.78e-27 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs9372498 0.536 rs72952733 chr6:118834452 A/G cg15382696 chr6:118971807 C6orf204 0.58 7.4 0.38 1.11e-12 Diastolic blood pressure; CRC trans rs1499614 1.000 rs2707838 chr7:66159201 C/T cg10756647 chr7:56101905 PSPH 0.77 8.1 0.41 1.09e-14 Gout; CRC cis rs561341 0.714 rs75861674 chr17:30304317 A/G cg19193384 chr17:30244184 NA -0.53 -6.7 -0.35 9.26e-11 Hip circumference adjusted for BMI; CRC cis rs9911578 0.935 rs2567912 chr17:56731270 T/C cg05425664 chr17:57184151 TRIM37 -0.51 -8.03 -0.41 1.69e-14 Intelligence (multi-trait analysis); CRC cis rs733592 1.000 rs1859440 chr12:48427329 T/C cg21466736 chr12:48725269 NA 0.46 7.35 0.38 1.63e-12 Plateletcrit; CRC cis rs1218582 0.774 rs12036859 chr1:154859940 A/C cg06221963 chr1:154839813 KCNN3 0.83 16.51 0.67 5.12e-45 Prostate cancer; CRC cis rs921968 0.509 rs655441 chr2:219357545 C/T cg02176678 chr2:219576539 TTLL4 0.54 8.69 0.43 1.78e-16 Mean corpuscular hemoglobin concentration; CRC cis rs7647973 0.580 rs2117938 chr3:49263850 A/G cg03060546 chr3:49711283 APEH -0.48 -7.18 -0.37 4.7e-12 Menarche (age at onset); CRC cis rs7589728 0.514 rs12465706 chr2:88467459 C/A cg14558114 chr2:88469736 THNSL2 0.59 6.0 0.31 5.24e-9 Plasma clusterin levels; CRC cis rs2444240 0.902 rs626225 chr11:120034115 G/A cg04390734 chr11:120039366 NA 0.28 5.65 0.3 3.44e-8 Corneal curvature; CRC trans rs12478296 0.901 rs6731775 chr2:242999443 T/C cg06834434 chr14:75079333 LTBP2 0.56 7.13 0.37 6.55e-12 Obesity-related traits; CRC cis rs4862750 0.758 rs2375915 chr4:187896255 A/C cg27532560 chr4:187881888 NA -0.56 -10.38 -0.5 4.98e-22 Lobe attachment (rater-scored or self-reported); CRC trans rs6546043 0.756 rs1362797 chr2:64128592 C/T cg20306022 chr2:7947960 NA -0.52 -5.98 -0.31 5.87e-9 Clozapine-induced agranulocytosis; CRC cis rs7246657 0.882 rs10422667 chr19:37937876 T/C cg23950597 chr19:37808831 NA -0.54 -6.46 -0.34 3.68e-10 Coronary artery calcification; CRC cis rs17152411 0.895 rs3940439 chr10:126584531 C/G cg07906193 chr10:126599966 NA 0.57 6.47 0.34 3.48e-10 Height; CRC cis rs1862618 0.853 rs6450408 chr5:56098146 T/C cg12311346 chr5:56204834 C5orf35 -0.8 -10.46 -0.5 2.64e-22 Initial pursuit acceleration; CRC cis rs13191362 1.000 rs13199223 chr6:163001083 T/C cg06582575 chr6:163149167 PACRG;PARK2 0.77 10.7 0.51 3.98e-23 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs26868 0.690 rs26835 chr16:2237549 C/T cg07587117 chr16:2239488 CASKIN1 0.58 11.06 0.52 2.13e-24 Height; CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg21150049 chr12:50677498 LIMA1 0.36 6.13 0.32 2.46e-9 Obesity-related traits; CRC cis rs6933660 0.665 rs6921042 chr6:151732385 T/C cg10883421 chr6:151773342 RMND1;C6orf211 0.71 12.45 0.57 2.06e-29 Menarche (age at onset); CRC cis rs6860806 0.661 rs28472559 chr5:131581611 G/A cg20512303 chr5:131592959 PDLIM4 0.32 6.17 0.32 1.97e-9 Breast cancer; CRC cis rs7091068 0.507 rs913046 chr10:95408484 A/C cg20715218 chr10:95462985 C10orf4 0.46 6.5 0.34 2.98e-10 Urinary tract infection frequency; CRC trans rs2303319 0.504 rs62188988 chr2:162531068 T/C cg27113153 chr11:123612418 ZNF202 -0.7 -6.17 -0.32 1.97e-9 Cognitive function; CRC cis rs972578 0.936 rs6002991 chr22:43370260 C/G cg01576275 chr22:43409880 NA -0.45 -7.28 -0.37 2.47e-12 Mean platelet volume; CRC trans rs9329221 0.716 rs11989640 chr8:10256054 A/G cg06636001 chr8:8085503 FLJ10661 -0.47 -6.5 -0.34 2.99e-10 Neuroticism; CRC cis rs10504229 0.683 rs55637580 chr8:58135419 C/T cg02290350 chr8:58132656 NA -0.58 -8.16 -0.41 7.29e-15 Developmental language disorder (linguistic errors); CRC cis rs10503871 0.625 rs4292648 chr8:30324803 C/T cg26383811 chr8:30366931 RBPMS 0.48 7.63 0.39 2.5e-13 Metabolite levels (X-11787); CRC cis rs7312933 0.558 rs11181467 chr12:42765250 C/T cg11827402 chr12:42719852 PPHLN1;ZCRB1 0.68 9.75 0.47 6.81e-20 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CRC cis rs7811142 0.943 rs28578163 chr7:100044754 A/G cg00814883 chr7:100076585 TSC22D4 -0.72 -9.44 -0.46 7.01e-19 Platelet count; CRC cis rs6586163 0.872 rs1926200 chr10:90746533 G/A cg13456138 chr10:90753195 FAS -0.44 -6.61 -0.34 1.54e-10 Chronic lymphocytic leukemia; CRC cis rs798554 0.797 rs798493 chr7:2798731 A/G cg19717773 chr7:2847554 GNA12 -0.47 -6.69 -0.35 9.36e-11 Height; CRC cis rs10504229 0.683 rs35244711 chr8:58117762 T/G cg05313129 chr8:58192883 C8orf71 -0.43 -6.11 -0.32 2.74e-9 Developmental language disorder (linguistic errors); CRC cis rs8023845 0.954 rs1680156 chr15:40447265 T/C cg20259534 chr15:40453036 BUB1B 0.5 5.74 0.3 2.11e-8 Chronic lymphocytic leukemia; CRC cis rs796364 1.000 rs1509835 chr2:200814809 C/G cg25936922 chr2:200820526 C2orf60;C2orf47 0.67 7.27 0.37 2.61e-12 Schizophrenia; CRC cis rs3106136 0.546 rs7685121 chr4:95175682 G/A cg11021082 chr4:95130006 SMARCAD1 -0.59 -9.42 -0.46 8.39e-19 Capecitabine sensitivity; CRC cis rs3806843 0.966 rs2337516 chr5:140140853 A/G cg19875535 chr5:140030758 IK -0.6 -9.84 -0.48 3.36e-20 Depressive symptoms (multi-trait analysis); CRC cis rs12477438 0.520 rs6708576 chr2:99801308 G/A cg26064155 chr2:99771622 LIPT1;TSGA10 0.83 14.89 0.63 1.08e-38 Chronic sinus infection; CRC cis rs75804782 0.557 rs3769118 chr2:239342542 C/G cg18131467 chr2:239335373 ASB1 -0.69 -7.49 -0.38 6.5e-13 Morning vs. evening chronotype;Chronotype; CRC cis rs7215564 0.730 rs34588273 chr17:78571465 C/T cg09596252 chr17:78655493 RPTOR 0.68 6.37 0.33 6.19e-10 Myopia (pathological); CRC cis rs6834538 0.692 rs116138196 chr4:113399192 A/G cg10021238 chr4:113569128 MIR367;LARP7 -0.39 -5.75 -0.3 2.02e-8 Free thyroxine concentration; CRC cis rs2230307 0.572 rs514090 chr1:100563186 C/G cg24955406 chr1:100503596 HIAT1 0.56 6.71 0.35 8.78e-11 Carotid intima media thickness; CRC cis rs875971 0.767 rs1695815 chr7:65831344 A/G cg12463550 chr7:65579703 CRCP 0.48 6.96 0.36 1.89e-11 Aortic root size; CRC cis rs4523957 0.928 rs749240 chr17:2186100 A/G cg16513277 chr17:2031491 SMG6 0.63 10.12 0.49 3.83e-21 Autism spectrum disorder or schizophrenia;Schizophrenia; CRC cis rs9393777 0.513 rs9348728 chr6:26634436 G/A cg12292205 chr6:26970375 C6orf41 -0.6 -6.75 -0.35 6.71e-11 Intelligence (multi-trait analysis); CRC cis rs734999 1.000 rs734999 chr1:2513216 C/T cg18854424 chr1:2615690 NA 0.39 7.54 0.38 4.66e-13 Ulcerative colitis; CRC cis rs3790455 0.610 rs3790461 chr1:156469364 A/G cg14087168 chr1:156450669 MEF2D 0.35 6.27 0.33 1.16e-9 Migraine; CRC trans rs1814175 0.645 rs1721995 chr11:49915488 A/G cg03929089 chr4:120376271 NA -0.9 -15.65 -0.65 1.22e-41 Height; CRC cis rs9303401 0.659 rs17822908 chr17:56801778 T/C cg10487724 chr17:56770010 TEX14;RAD51C 0.79 10.0 0.48 1.01e-20 Cognitive test performance; CRC cis rs7923609 0.905 rs10740129 chr10:65250808 G/A cg08743896 chr10:65200160 JMJD1C -0.41 -5.93 -0.31 7.58e-9 Educational attainment;Liver enzyme levels (alkaline phosphatase); CRC trans rs875971 0.660 rs2191268 chr7:66110224 C/T cg23753021 chr10:89623142 PTEN;KILLIN -0.39 -5.97 -0.31 6.24e-9 Aortic root size; CRC cis rs7613875 0.620 rs17657664 chr3:50032008 T/G cg05623727 chr3:50126028 RBM5 0.6 10.52 0.5 1.68e-22 Body mass index; CRC trans rs9291683 0.692 rs1558489 chr4:10325489 T/A cg26043149 chr18:55253948 FECH -0.55 -8.28 -0.42 3.07e-15 Bone mineral density; CRC cis rs73206853 0.563 rs73194047 chr12:111191926 G/A cg12870014 chr12:110450643 ANKRD13A 0.72 8.46 0.42 9.05e-16 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC cis rs1552244 1.000 rs3846177 chr3:10068572 G/T cg00166722 chr3:10149974 C3orf24 0.65 8.86 0.44 5.13e-17 Alzheimer's disease; CRC cis rs7493 1.000 rs17876124 chr7:95045258 C/G cg20119798 chr7:94954144 PON1 -0.49 -6.26 -0.33 1.21e-9 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs10751667 0.643 rs10751669 chr11:942344 C/G cg06064525 chr11:970664 AP2A2 0.34 6.81 0.35 4.71e-11 Alzheimer's disease (late onset); CRC cis rs10540 0.908 rs12792111 chr11:520921 G/C cg03352830 chr11:487213 PTDSS2 0.65 7.4 0.38 1.15e-12 Body mass index; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg20986421 chr1:201798455 IPO9 0.37 6.02 0.31 4.74e-9 Intelligence (multi-trait analysis); CRC cis rs13108904 0.967 rs13150571 chr4:1278636 C/G cg19318889 chr4:1322082 MAEA 0.4 5.74 0.3 2.13e-8 Obesity-related traits; CRC cis rs9325144 0.647 rs34963631 chr12:38912260 T/A cg26384229 chr12:38710491 ALG10B -0.52 -7.43 -0.38 9.51e-13 Morning vs. evening chronotype; CRC cis rs4972806 0.776 rs2072589 chr2:177042871 C/T cg03152288 chr2:177042942 NA 0.8 13.01 0.58 1.74e-31 IgG glycosylation; CRC cis rs2289583 0.573 rs12148555 chr15:75395475 C/T cg14664628 chr15:75095509 CSK 0.45 6.15 0.32 2.26e-9 Systemic lupus erythematosus; CRC cis rs9322193 0.884 rs10872647 chr6:150079823 T/C cg04369109 chr6:150039330 LATS1 -0.43 -5.61 -0.3 4.31e-8 Lung cancer; CRC cis rs1005277 0.579 rs932538 chr10:38381314 T/C cg25427524 chr10:38739819 LOC399744 -0.77 -14.07 -0.61 1.6e-35 Extrinsic epigenetic age acceleration; CRC cis rs6860806 0.507 rs2631369 chr5:131705266 G/C cg24060327 chr5:131705240 SLC22A5 0.55 8.59 0.43 3.55e-16 Breast cancer; CRC cis rs977987 0.778 rs4888413 chr16:75443223 C/A cg03315344 chr16:75512273 CHST6 0.54 9.08 0.45 1.01e-17 Dupuytren's disease; CRC cis rs881375 1.000 rs10117059 chr9:123653477 G/C cg00246817 chr9:123691163 NA -0.47 -5.95 -0.31 6.98e-9 Rheumatoid arthritis; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg16585985 chr1:161360266 NA 0.42 6.0 0.31 5.3300000000000004e-09 Response to antipsychotic treatment; CRC cis rs9517320 0.935 rs1886089 chr13:99124356 C/T cg20487152 chr13:99095054 FARP1 0.36 5.91 0.31 8.46e-9 Longevity; CRC cis rs735539 0.958 rs1075690 chr13:21279690 G/A cg04906043 chr13:21280425 IL17D -0.45 -6.94 -0.36 2.12e-11 Dental caries; CRC cis rs6951245 1.000 rs79422648 chr7:1080241 T/C cg24642844 chr7:1081250 C7orf50 -0.78 -9.34 -0.46 1.44e-18 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs9614461 0.826 rs9614649 chr22:45746097 C/A cg01808030 chr22:45809952 RIBC2;SMC1B 0.61 6.7 0.35 8.89e-11 Tonsillectomy; CRC cis rs4862750 0.872 rs4862747 chr4:187877236 A/T cg03647317 chr4:187891568 NA 0.53 9.92 0.48 1.85e-20 Lobe attachment (rater-scored or self-reported); CRC cis rs801193 0.660 rs2659914 chr7:66156914 C/T cg00343986 chr7:65444356 GUSB 0.43 6.14 0.32 2.41e-9 Aortic root size; CRC cis rs9814567 1.000 rs11919350 chr3:134235970 G/C cg06541857 chr3:134203789 ANAPC13;CEP63 0.39 5.71 0.3 2.53e-8 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs875971 0.862 rs1083554 chr7:65852341 T/C cg18252515 chr7:66147081 NA -0.42 -5.99 -0.31 5.64e-9 Aortic root size; CRC cis rs972578 1.000 rs4822249 chr22:43403506 C/G cg01576275 chr22:43409880 NA -0.51 -8.38 -0.42 1.53e-15 Mean platelet volume; CRC cis rs600806 0.778 rs12145677 chr1:110023610 G/A cg23032129 chr1:109941072 SORT1 0.26 5.62 0.3 4.11e-8 Intelligence (multi-trait analysis); CRC cis rs780096 0.546 rs7563162 chr2:27631191 C/T cg12000995 chr2:27665139 KRTCAP3 -0.32 -6.8 -0.35 5.09e-11 Total body bone mineral density; CRC cis rs1863824 0.502 rs11202058 chr10:88282611 G/A cg07322936 chr10:88137208 NA -0.59 -7.69 -0.39 1.72e-13 Schizophrenia; CRC cis rs17376456 0.877 rs10073039 chr5:93467709 A/G cg21475434 chr5:93447410 FAM172A 0.74 7.63 0.39 2.51e-13 Diabetic retinopathy; CRC cis rs10791323 0.569 rs10750541 chr11:133713189 A/C cg06766960 chr11:133703094 NA 0.35 5.65 0.3 3.57e-8 Childhood ear infection; CRC cis rs9487051 0.724 rs13200047 chr6:109633244 T/C cg01475377 chr6:109611718 NA -0.37 -6.01 -0.31 4.99e-9 Reticulocyte fraction of red cells; CRC cis rs780096 0.587 rs6743819 chr2:27567407 G/T cg17158414 chr2:27665306 KRTCAP3 -0.27 -5.78 -0.3 1.78e-8 Total body bone mineral density; CRC cis rs2996428 0.667 rs61768932 chr1:3765671 G/C cg13057898 chr1:3703894 LRRC47 0.55 7.21 0.37 3.83e-12 Red cell distribution width; CRC cis rs2769264 0.505 rs4246526 chr1:151403916 G/T cg18801370 chr1:151430492 POGZ 0.52 6.11 0.32 2.76e-9 Blood trace element (Cu levels); CRC cis rs7147624 1.000 rs2898816 chr14:66008160 T/C cg03016385 chr14:66212404 NA -1.04 -10.68 -0.51 4.76e-23 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs11722228 1.000 rs4697695 chr4:9915850 C/T cg11266682 chr4:10021025 SLC2A9 0.38 6.63 0.34 1.37e-10 Gout;Urate levels;Serum uric acid levels; CRC cis rs9326248 0.603 rs7396061 chr11:116750874 A/C cg26566898 chr11:117069891 TAGLN 0.31 6.46 0.34 3.69e-10 Blood protein levels; CRC cis rs780096 0.506 rs1647265 chr2:27692261 A/G cg22903471 chr2:27725779 GCKR -0.37 -6.06 -0.32 3.65e-9 Total body bone mineral density; CRC cis rs736408 0.812 rs6778329 chr3:52824610 G/A cg05573699 chr3:52720067 GNL3;PBRM1 -0.42 -5.66 -0.3 3.21e-8 Bipolar disorder; CRC cis rs9733 0.519 rs2184833 chr1:150675483 C/T cg10589385 chr1:150898437 SETDB1 0.31 6.47 0.34 3.46e-10 Tonsillectomy; CRC cis rs9457247 1.000 rs10946199 chr6:167404492 G/A cg23791538 chr6:167370224 RNASET2 -0.38 -5.94 -0.31 7.32e-9 Crohn's disease; CRC cis rs1467026 0.606 rs9814180 chr3:12818386 A/G cg24848339 chr3:12840334 CAND2 0.33 6.12 0.32 2.6e-9 P wave duration; CRC cis rs68170813 0.599 rs12532849 chr7:106959226 A/C cg02696742 chr7:106810147 HBP1 -0.57 -6.31 -0.33 8.9e-10 Coronary artery disease; CRC cis rs2032447 0.867 rs9295683 chr6:26069495 C/T cg03517284 chr6:25882590 NA -0.43 -6.02 -0.31 4.67e-9 Intelligence (multi-trait analysis); CRC cis rs561341 0.710 rs9900031 chr17:30199537 T/C cg12193833 chr17:30244370 NA 0.49 6.06 0.32 3.63e-9 Hip circumference adjusted for BMI; CRC cis rs863345 0.604 rs12025831 chr1:158496282 G/A cg12129480 chr1:158549410 OR10X1 -0.27 -5.66 -0.3 3.36e-8 Pneumococcal bacteremia; CRC cis rs921968 0.643 rs523396 chr2:219338789 T/G cg02176678 chr2:219576539 TTLL4 0.48 7.96 0.4 2.84e-14 Mean corpuscular hemoglobin concentration; CRC cis rs1707322 1.000 rs4660903 chr1:46457601 A/G cg06784218 chr1:46089804 CCDC17 0.52 9.22 0.45 3.7e-18 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs7605827 0.857 rs9973946 chr2:15631022 C/T cg19274914 chr2:15703543 NA 0.39 5.9 0.31 8.83e-9 Educational attainment (years of education); CRC cis rs3736485 0.966 rs4775960 chr15:51891698 C/G cg08986416 chr15:51914746 DMXL2 -0.47 -6.86 -0.35 3.39e-11 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs597539 0.652 rs584108 chr11:68630282 A/T cg11716795 chr11:68671300 MRPL21;IGHMBP2 -0.82 -13.52 -0.6 2.04e-33 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs73206853 0.841 rs73191840 chr12:110970457 A/G cg12870014 chr12:110450643 ANKRD13A 0.81 8.45 0.42 9.67e-16 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC cis rs4665809 0.590 rs62128457 chr2:26467347 C/A cg25036284 chr2:26402008 FAM59B 0.61 7.76 0.39 1.09e-13 Gut microbiome composition (summer); CRC cis rs7927771 0.929 rs66749409 chr11:47568074 C/T cg20307385 chr11:47447363 PSMC3 -0.55 -7.75 -0.39 1.19e-13 Subjective well-being; CRC cis rs2032447 0.672 rs9379811 chr6:25955197 G/C cg12588279 chr6:26043732 HIST1H2BB 0.4 5.83 0.31 1.3e-8 Intelligence (multi-trait analysis); CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg26462404 chr19:2270807 OAZ1 0.48 6.26 0.33 1.21e-9 Thyroid stimulating hormone; CRC cis rs10463316 0.747 rs10077700 chr5:150768324 A/T cg03212797 chr5:150827313 SLC36A1 -0.5 -7.92 -0.4 3.67e-14 Metabolite levels (Pyroglutamine); CRC cis rs72781680 1.000 rs72781648 chr2:24210333 T/C cg08917208 chr2:24149416 ATAD2B 0.9 9.13 0.45 6.93e-18 Lymphocyte counts; CRC cis rs9398803 0.799 rs1538170 chr6:126752874 C/T cg19875578 chr6:126661172 C6orf173 0.42 5.76 0.3 1.91e-8 Male-pattern baldness; CRC cis rs2153535 0.580 rs1932281 chr6:8473765 A/G cg07606381 chr6:8435919 SLC35B3 0.68 10.9 0.51 8.26e-24 Motion sickness; CRC cis rs738322 0.967 rs133013 chr22:38570912 C/T cg25457927 chr22:38595422 NA -0.35 -7.4 -0.38 1.13e-12 Cutaneous nevi; CRC cis rs7923609 0.875 rs10822143 chr10:64887856 C/T cg08743896 chr10:65200160 JMJD1C -0.42 -5.74 -0.3 2.2e-8 Educational attainment;Liver enzyme levels (alkaline phosphatase); CRC trans rs9329221 0.620 rs6601427 chr8:10156025 A/G cg08975724 chr8:8085496 FLJ10661 -0.46 -7.1 -0.36 7.68e-12 Neuroticism; CRC cis rs57221529 0.713 rs72703072 chr5:590626 A/G cg16447950 chr5:562315 NA -0.79 -10.45 -0.5 2.87e-22 Lung disease severity in cystic fibrosis; CRC cis rs3858526 0.834 rs10839160 chr11:6002113 T/C cg13902645 chr11:5959945 NA -0.53 -6.7 -0.35 9.32e-11 DNA methylation (variation); CRC cis rs10193935 0.901 rs2374405 chr2:42479874 A/C cg27598129 chr2:42591480 NA -0.7 -8.04 -0.41 1.62e-14 Colonoscopy-negative controls vs population controls; CRC cis rs2295359 0.892 rs17375018 chr1:67655147 A/G cg03340356 chr1:67600835 NA -0.29 -6.54 -0.34 2.29e-10 Psoriasis; CRC cis rs1975991 0.597 rs715790 chr3:187985004 A/G cg17585528 chr3:187988060 LPP 0.49 6.91 0.36 2.46e-11 White matter integrity (bipolar disorder risk interaction); CRC cis rs501120 1.000 rs671765 chr10:44752976 A/G cg09554077 chr10:44749378 NA 0.86 12.64 0.57 3.9e-30 Coronary artery disease;Coronary heart disease; CRC cis rs2243480 1.000 rs58062456 chr7:65394852 G/T cg12463550 chr7:65579703 CRCP 0.63 6.04 0.32 4.17e-9 Diabetic kidney disease; CRC cis rs9325144 0.555 rs28738714 chr12:38706912 G/A cg13010199 chr12:38710504 ALG10B -0.41 -5.94 -0.31 7.44e-9 Morning vs. evening chronotype; CRC cis rs1055129 0.560 rs56248937 chr17:73915153 T/A cg08125733 chr17:73851984 WBP2 0.47 6.13 0.32 2.49e-9 White matter hyperintensity burden; CRC trans rs773506 0.965 rs298718 chr9:94081674 A/G cg20300514 chr1:2120985 C1orf86;LOC100128003 0.4 5.98 0.31 5.86e-9 Type 2 diabetes nephropathy; CRC cis rs6681460 1.000 rs4655636 chr1:67068537 A/G cg02459107 chr1:67143332 SGIP1 0.46 8.15 0.41 7.87e-15 Presence of antiphospholipid antibodies; CRC cis rs6933660 0.676 rs3757316 chr6:151774339 A/G cg14262678 chr6:151773367 RMND1;C6orf211 -0.45 -6.88 -0.35 3e-11 Menarche (age at onset); CRC cis rs13108904 0.518 rs4974602 chr4:1342391 C/T cg00684032 chr4:1343700 KIAA1530 0.61 8.58 0.43 3.86e-16 Obesity-related traits; CRC cis rs6942756 0.806 rs7794622 chr7:128996268 T/C cg02491457 chr7:128862824 NA -0.63 -8.6 -0.43 3.31e-16 White matter hyperintensity burden; CRC cis rs6723226 0.610 rs458628 chr2:32515398 G/A cg02381751 chr2:32503542 YIPF4 0.58 8.38 0.42 1.56e-15 Intelligence (multi-trait analysis); CRC cis rs66573146 0.803 rs59809420 chr4:6969928 G/T cg00086871 chr4:6988644 TBC1D14 1.07 7.19 0.37 4.43e-12 Granulocyte percentage of myeloid white cells; CRC cis rs977987 0.843 rs6564259 chr16:75447393 T/G cg03315344 chr16:75512273 CHST6 0.54 9.08 0.45 1.04e-17 Dupuytren's disease; CRC cis rs10504229 0.683 rs6984765 chr8:58127124 T/C cg02725872 chr8:58115012 NA -0.64 -11.55 -0.54 3.85e-26 Developmental language disorder (linguistic errors); CRC trans rs7647973 0.626 rs9835157 chr3:49797769 G/A cg21659725 chr3:3221576 CRBN 0.63 7.03 0.36 1.21e-11 Menarche (age at onset); CRC trans rs11722228 0.549 rs55848383 chr4:10081117 C/A cg26043149 chr18:55253948 FECH 1.13 17.09 0.69 2.61e-47 Gout;Urate levels;Serum uric acid levels; CRC cis rs9467773 0.620 rs1027203 chr6:26639332 G/C cg09904177 chr6:26538194 HMGN4 0.64 9.39 0.46 1.01e-18 Intelligence (multi-trait analysis); CRC cis rs2882667 0.858 rs13177503 chr5:138432759 G/C cg09476006 chr5:138032270 NA 0.44 6.78 0.35 5.56e-11 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs7177699 0.525 rs7166770 chr15:79113568 A/G cg15571903 chr15:79123663 NA 0.3 5.83 0.31 1.33e-8 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; CRC cis rs6951245 1.000 rs77083167 chr7:1071823 C/T cg18402987 chr7:1209562 NA 0.64 6.77 0.35 6.03e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs769267 0.930 rs9917108 chr19:19572785 A/G cg02546618 chr19:19431379 KIAA0892;SF4 0.45 6.19 0.32 1.78e-9 Tonsillectomy; CRC cis rs12220238 1.000 rs4745740 chr10:75942469 G/A cg19889307 chr10:75911429 ADK;AP3M1 0.59 5.88 0.31 9.86e-9 Soluble interleukin-2 receptor subunit alpha; CRC cis rs2976388 0.609 rs2585149 chr8:143793320 T/C cg12516270 chr8:143859308 LYNX1 0.44 7.79 0.39 8.89e-14 Urinary tract infection frequency; CRC cis rs939658 0.805 rs11638625 chr15:79434787 T/G cg17916960 chr15:79447300 NA -0.46 -7.42 -0.38 9.78e-13 Refractive error; CRC cis rs8177253 0.798 rs9871148 chr3:133507509 T/C cg12373951 chr3:133503437 NA 0.26 6.56 0.34 2.05e-10 Iron status biomarkers; CRC cis rs6502050 0.805 rs9898507 chr17:80119628 C/T cg25804541 chr17:80189381 SLC16A3 -0.31 -5.95 -0.31 6.84e-9 Life satisfaction; CRC cis rs2298450 0.717 rs62232368 chr21:37626011 C/T cg02919814 chr21:37666008 DOPEY2 -0.5 -6.58 -0.34 1.84e-10 Schizophrenia; CRC trans rs944990 0.595 rs10123378 chr9:96375217 C/T cg05021743 chr1:151810893 C2CD4D;LOC100132111 0.24 6.37 0.33 6.46e-10 Body mass index; CRC cis rs12580194 0.593 rs115471673 chr12:55766516 A/G cg23425280 chr12:56401806 NA 0.47 5.74 0.3 2.13e-8 Cancer; CRC cis rs4713118 0.869 rs6914924 chr6:27711530 C/T cg08798685 chr6:27730294 NA -0.42 -6.26 -0.33 1.23e-9 Parkinson's disease; CRC cis rs1707322 0.964 rs6675259 chr1:46502295 G/A cg03146154 chr1:46216737 IPP -0.56 -7.67 -0.39 1.99e-13 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs9807989 0.765 rs6751967 chr2:102967413 T/C cg03938978 chr2:103052716 IL18RAP 0.37 5.97 0.31 6.2e-9 Asthma; CRC cis rs858239 1.000 rs199347 chr7:23293746 A/G cg00469287 chr7:23338798 C7orf30 0.42 5.61 0.3 4.3e-8 Cerebrospinal fluid biomarker levels; CRC cis rs10876993 0.890 rs1678539 chr12:58060359 A/G cg15848620 chr12:58087721 OS9 -0.64 -8.82 -0.44 6.71e-17 Celiac disease or Rheumatoid arthritis; CRC cis rs9309473 1.000 rs7607014 chr2:73730174 C/T cg20560298 chr2:73613845 ALMS1 0.47 5.77 0.3 1.83e-8 Metabolite levels; CRC cis rs4713118 0.629 rs203889 chr6:28021775 T/G cg21251018 chr6:28226885 NKAPL 0.45 6.37 0.33 6.32e-10 Parkinson's disease; CRC cis rs798766 1.000 rs798754 chr4:1720757 A/G cg05874882 chr4:1763078 NA -0.38 -7.27 -0.37 2.67e-12 Bladder cancer;Urinary bladder cancer; CRC cis rs7173389 0.551 rs75372618 chr15:73680843 A/G cg01796676 chr15:73680284 NA 0.59 5.84 0.31 1.28e-8 Resting heart rate; CRC cis rs8177253 1.000 rs8177252 chr3:133480174 C/A cg08048268 chr3:133502702 NA -0.36 -6.91 -0.36 2.51e-11 Iron status biomarkers; CRC cis rs6831352 0.918 rs2602891 chr4:100043284 C/T cg12011299 chr4:100065546 ADH4 0.5 9.46 0.46 6e-19 Alcohol dependence; CRC cis rs4474465 0.646 rs10899556 chr11:78278986 C/T cg27205649 chr11:78285834 NARS2 0.53 6.88 0.35 2.99e-11 Alzheimer's disease (survival time); CRC cis rs6952808 0.771 rs10244946 chr7:1921068 A/G cg21782813 chr7:2030301 MAD1L1 -0.4 -7.23 -0.37 3.46e-12 Bipolar disorder and schizophrenia; CRC cis rs4713118 0.616 rs9348789 chr6:28025486 C/T cg02683197 chr6:28174875 NA 0.75 9.8 0.48 4.46e-20 Parkinson's disease; CRC cis rs6456156 0.773 rs6456159 chr6:167529272 T/A cg05540913 chr6:167530185 CCR6 -0.4 -7.32 -0.37 1.91e-12 Primary biliary cholangitis; CRC cis rs68170813 0.559 rs6963917 chr7:106953427 T/G cg02696742 chr7:106810147 HBP1 -0.58 -6.22 -0.32 1.55e-9 Coronary artery disease; CRC cis rs2243480 1.000 rs6964245 chr7:65718717 G/A cg25985355 chr7:65971099 NA 0.51 5.77 0.3 1.81e-8 Diabetic kidney disease; CRC cis rs6952808 0.823 rs58222895 chr7:1885064 G/A cg02951883 chr7:2050386 MAD1L1 -0.64 -10.44 -0.5 3.12e-22 Bipolar disorder and schizophrenia; CRC cis rs9649213 0.593 rs13307593 chr7:97986146 A/G cg21770322 chr7:97807741 LMTK2 0.52 8.52 0.43 5.7e-16 Prostate cancer (SNP x SNP interaction); CRC cis rs2832191 0.791 rs2832179 chr21:30480366 C/T cg08807101 chr21:30365312 RNF160 -0.64 -10.44 -0.5 3.06e-22 Dental caries; CRC cis rs12142240 0.698 rs17361763 chr1:46810670 T/C cg14993813 chr1:46806288 NSUN4 -0.49 -6.23 -0.32 1.43e-9 Menopause (age at onset); CRC cis rs1891275 0.515 rs10881957 chr10:93501876 C/T cg07889827 chr10:93443413 NA -0.41 -6.97 -0.36 1.76e-11 Intelligence (multi-trait analysis); CRC cis rs2952156 0.876 rs2313171 chr17:37833842 T/C cg11212589 chr17:38028394 ZPBP2 0.35 6.15 0.32 2.26e-9 Asthma; CRC cis rs172166 0.637 rs1225597 chr6:28162087 C/T cg02683197 chr6:28174875 NA 0.73 10.73 0.51 3.07e-23 Cardiac Troponin-T levels; CRC cis rs6912958 0.754 rs10755484 chr6:88244648 C/T cg08069147 chr6:88032118 GJB7;C6orf162 -0.54 -8.01 -0.4 1.96e-14 Monocyte percentage of white cells; CRC cis rs9457247 1.000 rs421214 chr6:167396629 A/G cg23791538 chr6:167370224 RNASET2 -0.38 -6.04 -0.32 4.11e-9 Crohn's disease; CRC cis rs17253792 0.822 rs76205307 chr14:56166038 C/T cg01858014 chr14:56050164 KTN1 -0.92 -7.3 -0.37 2.14e-12 Putamen volume; CRC cis rs6570726 0.599 rs455001 chr6:145854450 A/T cg13319975 chr6:146136371 FBXO30 -0.63 -9.23 -0.45 3.49e-18 Lobe attachment (rater-scored or self-reported); CRC cis rs2462686 1.000 rs788765 chr7:45996985 C/G cg23193639 chr7:45961078 IGFBP3 -0.38 -5.9 -0.31 9.01e-9 Major depressive disorder; CRC cis rs5769765 0.908 rs9616211 chr22:50317676 G/A cg02269571 chr22:50332266 NA -0.62 -7.7 -0.39 1.5700000000000001e-13 Schizophrenia; CRC trans rs11343 0.675 rs7359333 chr16:19262344 A/T cg04320405 chr7:131012679 MKLN1 -0.44 -6.0 -0.31 5.27e-9 Parkinson's disease; CRC trans rs11722228 0.522 rs73212880 chr4:10115692 T/A cg26043149 chr18:55253948 FECH 1.14 17.34 0.69 2.66e-48 Gout;Urate levels;Serum uric acid levels; CRC cis rs769267 0.965 rs2905425 chr19:19475717 G/C cg03709012 chr19:19516395 GATAD2A -0.73 -11.19 -0.53 7.47e-25 Tonsillectomy; CRC cis rs9611565 0.918 rs4822024 chr22:41757647 G/A cg03806693 chr22:41940476 POLR3H -0.94 -13.05 -0.58 1.21e-31 Vitiligo; CRC cis rs2153535 0.541 rs4637688 chr6:8446501 A/G cg07606381 chr6:8435919 SLC35B3 0.68 10.97 0.52 4.49e-24 Motion sickness; CRC cis rs6582630 0.555 rs11181657 chr12:38381858 T/C cg13010199 chr12:38710504 ALG10B -0.45 -6.31 -0.33 9.25e-10 Drug-induced liver injury (flucloxacillin); CRC cis rs8177253 0.931 rs8177256 chr3:133480276 G/T cg11941060 chr3:133502564 NA -0.59 -10.21 -0.49 1.99e-21 Iron status biomarkers; CRC cis rs1707322 1.000 rs4460583 chr1:46449918 C/G cg03146154 chr1:46216737 IPP 0.51 7.06 0.36 1.01e-11 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs9858542 0.953 rs7633271 chr3:49555963 T/C cg03060546 chr3:49711283 APEH -0.47 -6.56 -0.34 2.14e-10 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs9733 0.596 rs12089989 chr1:150715782 G/A cg15448220 chr1:150897856 SETDB1 0.42 5.99 0.31 5.36e-9 Tonsillectomy; CRC cis rs28386778 0.897 rs2584615 chr17:61927774 T/C cg07362569 chr17:61921086 SMARCD2 0.36 5.6 0.3 4.41e-8 Prudent dietary pattern; CRC trans rs3733585 0.673 rs4467563 chr4:9953460 A/T cg26043149 chr18:55253948 FECH -0.5 -7.71 -0.39 1.51e-13 Cleft plate (environmental tobacco smoke interaction); CRC cis rs853679 0.517 rs4713146 chr6:28111536 A/T cg25164649 chr6:28176230 NA 0.78 9.66 0.47 1.33e-19 Depression; CRC cis rs7647973 1.000 rs3870341 chr3:49584745 A/G cg07636037 chr3:49044803 WDR6 0.67 8.39 0.42 1.44e-15 Menarche (age at onset); CRC cis rs16975963 0.644 rs7248397 chr19:38133211 A/G cg15135657 chr19:38346511 NA -0.45 -6.28 -0.33 1.06e-9 Longevity; CRC cis rs9875589 0.915 rs13097822 chr3:13969396 T/A cg19554555 chr3:13937349 NA 0.51 7.21 0.37 3.87e-12 Ovarian reserve; CRC cis rs787274 0.543 rs10116897 chr9:115633479 C/T cg13803584 chr9:115635662 SNX30 -0.66 -7.1 -0.36 7.51e-12 Age-related hearing impairment (SNP x SNP interaction); CRC trans rs877282 0.583 rs12356155 chr10:823940 C/T cg22713356 chr15:30763199 NA 0.79 9.0 0.44 1.83e-17 Uric acid levels; CRC cis rs7542091 0.579 rs34638782 chr1:210032055 C/G cg05527609 chr1:210001259 C1orf107 -0.56 -7.64 -0.39 2.37e-13 Monobrow; CRC cis rs7932354 0.528 rs4752962 chr11:47141670 C/G cg03339077 chr11:47165057 C11orf49 -0.46 -6.36 -0.33 6.65e-10 Bone mineral density (hip);Bone mineral density; CRC cis rs7692995 1.000 rs16896074 chr4:17947873 T/C cg08925142 chr4:18023851 LCORL -0.5 -5.62 -0.3 4.15e-8 Height; CRC cis rs454510 0.816 rs347904 chr1:120177620 C/T cg11530693 chr1:120165357 ZNF697 0.48 6.14 0.32 2.35e-9 Alcohol dependence or chronic alcoholic pancreatitis or alcohol-related liver cirrhosis; CRC trans rs2243480 1.000 rs4149468 chr7:65825690 T/C cg10756647 chr7:56101905 PSPH 0.75 7.85 0.4 6.01e-14 Diabetic kidney disease; CRC cis rs11123610 0.520 rs60644898 chr2:3718646 G/A cg10645314 chr2:3704589 ALLC -0.55 -6.45 -0.34 4.02e-10 Response to inhaled corticosteroid treatment in asthma (change in FEV1); CRC trans rs1455244 0.700 rs7229302 chr18:11508904 G/T cg02591199 chr4:113066609 C4orf32 0.42 6.27 0.33 1.12e-9 Schizophrenia; CRC cis rs798554 0.797 rs2107964 chr7:2863574 G/A cg19717773 chr7:2847554 GNA12 -0.48 -6.67 -0.35 1.05e-10 Height; CRC cis rs919433 0.963 rs4850786 chr2:198178608 A/G cg20885578 chr2:198174922 NA 0.4 6.2 0.32 1.69e-9 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC cis rs7605827 0.930 rs6750232 chr2:15714958 C/T cg19274914 chr2:15703543 NA 0.41 6.15 0.32 2.25e-9 Educational attainment (years of education); CRC cis rs1223397 0.651 rs2496148 chr6:13313553 A/G cg07912922 chr6:13274314 PHACTR1 0.37 5.81 0.3 1.48e-8 Blood pressure; CRC cis rs1971762 0.545 rs10783586 chr12:53980821 C/T cg06632207 chr12:54070931 ATP5G2 0.37 6.25 0.33 1.26e-9 Height; CRC cis rs561341 1.000 rs15654 chr17:30326360 A/C cg23018236 chr17:30244563 NA -0.67 -8.03 -0.4 1.78e-14 Hip circumference adjusted for BMI; CRC cis rs1865760 0.622 rs9295685 chr6:26071725 G/C cg16482183 chr6:26056742 HIST1H1C 0.52 7.65 0.39 2.24e-13 Height; CRC cis rs597539 0.521 rs2060982 chr11:68612927 A/G cg21963583 chr11:68658836 MRPL21 0.37 6.59 0.34 1.76e-10 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs6502050 0.835 rs9891962 chr17:80153594 T/C cg22110888 chr17:80059540 CCDC57 0.4 6.24 0.33 1.33e-9 Life satisfaction; CRC cis rs12148488 0.816 rs4886655 chr15:75385568 C/T cg09165964 chr15:75287851 SCAMP5 0.55 8.74 0.43 1.18e-16 Caffeine consumption; CRC cis rs9487051 0.768 rs2483913 chr6:109521042 G/A cg01475377 chr6:109611718 NA -0.34 -5.86 -0.31 1.15e-8 Reticulocyte fraction of red cells; CRC cis rs10504073 0.669 rs57085792 chr8:50018355 T/C cg00325661 chr8:49890786 NA 0.47 8.43 0.42 1.08e-15 Blood metabolite ratios; CRC cis rs8072100 0.967 rs7219303 chr17:45737701 A/G cg08085267 chr17:45401833 C17orf57 0.61 9.82 0.48 3.93e-20 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs10971721 0.822 rs10971764 chr9:33880100 C/T cg13495928 chr9:33750294 PRSS3 0.56 5.95 0.31 6.96e-9 Body mass index; CRC cis rs8044995 0.501 rs7189887 chr16:68353915 C/T cg09835421 chr16:68378352 PRMT7 -0.73 -7.6 -0.39 3.1e-13 Schizophrenia; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg22776125 chr6:167041314 RPS6KA2 0.44 6.34 0.33 7.61e-10 Response to antipsychotic treatment; CRC cis rs6951245 0.935 rs78573577 chr7:1089087 C/A cg04025307 chr7:1156635 C7orf50 0.64 6.66 0.34 1.16e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs1568889 1.000 rs12796293 chr11:28177723 C/T cg06544937 chr11:28130018 METT5D1;KIF18A -0.8 -11.25 -0.53 4.66e-25 Bipolar disorder; CRC cis rs6088580 0.634 rs6120666 chr20:33090718 A/G cg24642439 chr20:33292090 TP53INP2 0.4 6.69 0.35 9.72e-11 Glomerular filtration rate (creatinine); CRC cis rs2227631 0.505 rs12530730 chr7:100758591 T/A cg18465962 chr7:100767262 NA 0.6 8.36 0.42 1.83e-15 Plasminogen activator inhibitor type 1 levels (PAI-1); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg09423085 chr2:68478351 PPP3R1 0.41 5.99 0.31 5.42e-9 Intelligence (multi-trait analysis); CRC cis rs11971779 0.680 rs10274480 chr7:139052428 T/C cg23387468 chr7:139079360 LUC7L2 0.4 6.96 0.36 1.9e-11 Diisocyanate-induced asthma; CRC cis rs67478160 0.619 rs1040813 chr14:104306696 T/C cg08213375 chr14:104286397 PPP1R13B 0.63 13.15 0.59 4.91e-32 Schizophrenia; CRC cis rs2742417 0.967 rs1883096 chr3:45750015 C/T cg04837898 chr3:45731254 SACM1L -0.36 -5.92 -0.31 8e-9 Response to anti-depressant treatment in major depressive disorder; CRC cis rs72634258 0.945 rs4908724 chr1:8119251 G/T cg26816564 chr1:7831052 VAMP3 0.58 6.32 0.33 8.47e-10 Inflammatory bowel disease; CRC trans rs1814175 0.869 rs10769600 chr11:49681832 C/T cg21153622 chr11:89784906 NA -0.38 -5.96 -0.31 6.54e-9 Height; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg03403386 chr16:69373069 COG8;NIP7 0.45 6.59 0.34 1.76e-10 Intelligence (multi-trait analysis); CRC cis rs4718428 0.662 rs34577323 chr7:66310041 G/C cg18252515 chr7:66147081 NA -0.54 -7.49 -0.38 6.26e-13 Corneal structure; CRC cis rs9486719 1.000 rs2472886 chr6:96864876 C/T cg06623918 chr6:96969491 KIAA0776 0.81 9.48 0.46 5.18e-19 Migraine;Coronary artery disease; CRC cis rs2624839 0.704 rs12637671 chr3:50224562 G/A cg05623727 chr3:50126028 RBM5 -0.4 -6.09 -0.32 3.07e-9 Intelligence (multi-trait analysis); CRC cis rs8078723 1.000 rs3213762 chr17:38178627 A/G cg17344932 chr17:38183730 MED24;SNORD124 -0.47 -7.11 -0.37 7.21e-12 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); CRC cis rs4700695 0.719 rs27046 chr5:65439964 G/C cg21114390 chr5:65439923 SFRS12 -0.67 -9.04 -0.45 1.41e-17 Facial morphology (factor 19); CRC cis rs6502050 0.871 rs7226049 chr17:80071049 A/G cg02741985 chr17:80059408 CCDC57 -0.41 -6.56 -0.34 2.03e-10 Life satisfaction; CRC cis rs2011503 1.000 rs17684164 chr19:19626769 C/T cg11584989 chr19:19387371 SF4 0.57 6.39 0.33 5.7e-10 Bipolar disorder; CRC cis rs2836974 0.605 rs2836988 chr21:40707975 A/G cg11644478 chr21:40555479 PSMG1 -0.64 -9.86 -0.48 3.01e-20 Cognitive function; CRC cis rs637571 0.780 rs653914 chr11:65676516 A/G cg04055107 chr11:65626734 MUS81;CFL1 0.49 6.78 0.35 5.73e-11 Eosinophil percentage of white cells; CRC cis rs2832077 0.527 rs2142375 chr21:30223742 G/A cg24692254 chr21:30365293 RNF160 -0.44 -6.59 -0.34 1.7e-10 Cognitive test performance; CRC cis rs9372498 0.536 rs9489450 chr6:118904385 G/A cg24463073 chr6:118973353 C6orf204 0.51 6.75 0.35 6.86e-11 Diastolic blood pressure; CRC cis rs4689388 0.889 rs13101355 chr4:6293446 T/C cg25554036 chr4:6271136 WFS1 0.54 8.73 0.43 1.29e-16 Type 2 diabetes and other traits;Type 2 diabetes; CRC cis rs2404602 0.698 rs12909656 chr15:76664378 A/T cg03037974 chr15:76606532 NA -0.51 -7.64 -0.39 2.34e-13 Blood metabolite levels; CRC trans rs7395662 0.655 rs2202458 chr11:48856547 T/G cg21153622 chr11:89784906 NA 0.43 6.9 0.36 2.71e-11 HDL cholesterol; CRC cis rs1577917 0.958 rs13219504 chr6:86556917 G/A cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.57 -7.09 -0.36 8.38e-12 Response to antipsychotic treatment; CRC cis rs9916302 0.904 rs612194 chr17:37442707 T/A cg03013999 chr17:37608204 MED1 -0.49 -7.62 -0.39 2.81e-13 Glomerular filtration rate (creatinine); CRC cis rs12142240 0.583 rs5013330 chr1:46815154 G/A cg00530320 chr1:46809349 NSUN4 0.57 7.75 0.39 1.19e-13 Menopause (age at onset); CRC cis rs1799949 0.965 rs12950779 chr17:41306523 C/T cg23758822 chr17:41437982 NA 0.79 13.51 0.6 2.13e-33 Menopause (age at onset); CRC cis rs10256972 0.630 rs13235747 chr7:1129123 T/C cg18402987 chr7:1209562 NA 0.46 6.71 0.35 8.56e-11 Longevity;Endometriosis; CRC cis rs12760731 0.720 rs12022731 chr1:178416358 A/G cg00404053 chr1:178313656 RASAL2 0.96 10.09 0.49 4.81e-21 Obesity-related traits; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg19098826 chr2:32581711 BIRC6 0.5 7.23 0.37 3.33e-12 Response to antipsychotic treatment; CRC cis rs6665290 0.669 rs3768421 chr1:227177193 G/A cg10327440 chr1:227177885 CDC42BPA -0.99 -20.58 -0.75 4.47e-61 Myeloid white cell count; CRC cis rs1519814 0.915 rs10808507 chr8:121166429 G/A cg22335954 chr8:121166405 COL14A1 -0.6 -7.24 -0.37 3.12e-12 Breast cancer; CRC cis rs72945132 0.882 rs56770826 chr11:70128874 A/G cg00319359 chr11:70116639 PPFIA1 0.67 7.4 0.38 1.13e-12 Coronary artery disease; CRC cis rs1862618 0.671 rs173763 chr5:56225418 G/A cg24531977 chr5:56204891 C5orf35 -0.68 -10.3 -0.49 9.57e-22 Initial pursuit acceleration; CRC cis rs11190604 0.652 rs76629555 chr10:102191417 T/C cg07080220 chr10:102295463 HIF1AN 0.5 6.35 0.33 7.2e-10 Palmitoleic acid (16:1n-7) levels; CRC cis rs881375 1.000 rs6478486 chr9:123655329 T/C cg00246817 chr9:123691163 NA -0.47 -5.92 -0.31 8.01e-9 Rheumatoid arthritis; CRC cis rs9287719 0.624 rs10211190 chr2:10725428 A/G cg00105475 chr2:10696890 NA 0.45 6.98 0.36 1.62e-11 Prostate cancer; CRC cis rs4713118 0.824 rs13211701 chr6:27750079 T/C cg12172441 chr6:28176163 NA 0.54 7.07 0.36 9.53e-12 Parkinson's disease; CRC cis rs4713118 0.513 rs9368547 chr6:28028067 A/G cg21251018 chr6:28226885 NKAPL 0.49 7.47 0.38 7.1e-13 Parkinson's disease; CRC cis rs34779708 0.931 rs79749947 chr10:35277081 A/T cg03585969 chr10:35415529 CREM 0.66 8.82 0.44 6.68e-17 Inflammatory bowel disease;Crohn's disease; CRC cis rs763014 0.593 rs28455838 chr16:681966 T/C cg09263875 chr16:632152 PIGQ 0.76 11.9 0.55 2.17e-27 Height; CRC cis rs11123170 0.650 rs2289897 chr2:113977454 G/A cg21482265 chr2:113992762 PAX8;LOC440839;LOC654433 0.59 7.12 0.37 6.78e-12 Renal function-related traits (BUN); CRC trans rs10982213 0.830 rs2274163 chr9:117188714 C/T cg00167275 chr10:88854588 FAM35A;GLUD1 0.41 6.57 0.34 2e-10 Interleukin-6 levels; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg19022667 chr13:50367295 KPNA3 0.47 6.84 0.35 3.82e-11 Intelligence (multi-trait analysis); CRC cis rs4332037 0.722 rs4721140 chr7:1917635 A/T cg23422044 chr7:1970798 MAD1L1 -0.59 -7.77 -0.39 9.8e-14 Bipolar disorder; CRC cis rs1215050 0.791 rs1506438 chr4:98789542 C/T cg05340658 chr4:99064831 C4orf37 0.45 6.74 0.35 7.32e-11 Waist-to-hip ratio adjusted for body mass index; CRC cis rs6484504 0.600 rs12796587 chr11:31266443 T/C cg14844989 chr11:31128820 NA -0.34 -5.92 -0.31 7.98e-9 Red blood cell count; CRC cis rs9560113 1.000 rs9560107 chr13:112180146 G/A cg10483660 chr13:112241077 NA 0.36 5.81 0.3 1.49e-8 Menarche (age at onset); CRC cis rs10256972 0.552 rs2960830 chr7:1200641 T/C cg22907277 chr7:1156413 C7orf50 0.64 9.7 0.47 1e-19 Longevity;Endometriosis; CRC cis rs4713118 0.662 rs149970 chr6:27980220 C/T cg20933634 chr6:27740509 NA 0.45 6.01 0.31 4.94e-9 Parkinson's disease; CRC cis rs9296404 1 rs9296404 chr6:42925803 T/C cg26304593 chr6:42947056 PEX6 -0.46 -6.76 -0.35 6.47e-11 Plasma homocysteine levels (post-methionine load test); CRC cis rs9467773 0.572 rs2076029 chr6:26390830 T/C cg09904177 chr6:26538194 HMGN4 -0.43 -5.84 -0.31 1.23e-8 Intelligence (multi-trait analysis); CRC cis rs9733 0.628 rs11807409 chr1:150683423 C/T cg18016565 chr1:150552671 MCL1 0.45 6.53 0.34 2.56e-10 Tonsillectomy; CRC cis rs7223966 1.000 rs11654335 chr17:61797579 A/T cg23090583 chr17:61904693 PSMC5;FTSJ3 0.48 6.02 0.31 4.69e-9 Hip circumference adjusted for BMI;Body mass index; CRC cis rs1881797 1.000 rs1881794 chr1:247682920 G/C cg05639522 chr1:247681581 NA -0.5 -8.3 -0.42 2.71e-15 Acute lymphoblastic leukemia (childhood); CRC cis rs13256369 0.802 rs12680019 chr8:8561698 A/G cg18904891 chr8:8559673 CLDN23 0.53 7.02 0.36 1.26e-11 Obesity-related traits; CRC cis rs9303280 0.934 rs56380902 chr17:38066372 T/C cg00129232 chr17:37814104 STARD3 -0.47 -7.26 -0.37 2.84e-12 Self-reported allergy; CRC cis rs60871478 1.000 rs7795258 chr7:795227 A/G cg05535760 chr7:792225 HEATR2 0.79 10.59 0.5 9.23e-23 Cerebrospinal P-tau181p levels; CRC cis rs6502050 0.871 rs11870632 chr17:80075406 T/C cg25804541 chr17:80189381 SLC16A3 0.32 6.13 0.32 2.51e-9 Life satisfaction; CRC cis rs832540 0.656 rs832567 chr5:56152416 C/A cg18230493 chr5:56204884 C5orf35 -0.4 -5.67 -0.3 3.14e-8 Coronary artery disease; CRC cis rs7666738 0.830 rs13144771 chr4:99026935 G/C cg05340658 chr4:99064831 C4orf37 0.61 9.42 0.46 8.23e-19 Colonoscopy-negative controls vs population controls; CRC cis rs9987353 0.566 rs13260067 chr8:9071033 A/G cg06636001 chr8:8085503 FLJ10661 -0.57 -8.25 -0.41 3.82e-15 Recombination measurement; CRC cis rs7113874 0.569 rs11041962 chr11:8549623 C/T cg02811074 chr11:8615871 STK33 -0.36 -6.09 -0.32 3.19e-9 Body mass index in physically active individuals;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs28386778 1.000 rs2665849 chr17:61953670 T/C cg06873352 chr17:61820015 STRADA 0.77 14.36 0.62 1.26e-36 Prudent dietary pattern; CRC cis rs10504229 0.728 rs72650852 chr8:58150463 G/A cg05313129 chr8:58192883 C8orf71 -0.52 -6.54 -0.34 2.32e-10 Developmental language disorder (linguistic errors); CRC cis rs6500395 1.000 rs1120276 chr16:48598517 C/G cg04672837 chr16:48644449 N4BP1 0.44 6.5 0.34 2.95e-10 Response to tocilizumab in rheumatoid arthritis; CRC cis rs1129187 0.791 rs1129186 chr6:42932202 C/T cg05552183 chr6:42928497 GNMT 0.53 8.18 0.41 6.45e-15 Alzheimer's disease in APOE e4+ carriers; CRC cis rs1552244 0.554 rs17050705 chr3:10046398 G/C cg16606324 chr3:10149918 C3orf24 0.48 7.09 0.36 8.29e-12 Alzheimer's disease; CRC trans rs853679 0.546 rs13214023 chr6:28332141 A/G cg01620082 chr3:125678407 NA 0.81 6.7 0.35 8.78e-11 Depression; CRC cis rs473651 0.935 rs540636 chr2:239358341 T/C cg21699342 chr2:239360505 ASB1 0.58 10.4 0.5 4.36e-22 Multiple system atrophy; CRC cis rs4808199 0.947 rs754255 chr19:19578890 T/C cg03709012 chr19:19516395 GATAD2A 1.01 12.11 0.56 3.6e-28 Nonalcoholic fatty liver disease; CRC cis rs28386778 0.897 rs2665831 chr17:61912392 C/T cg23090583 chr17:61904693 PSMC5;FTSJ3 1.06 20.21 0.74 1.29e-59 Prudent dietary pattern; CRC cis rs713587 0.719 rs4665736 chr2:25187599 C/T cg22495460 chr2:25135724 ADCY3 0.66 11.01 0.52 3.24e-24 Body mass index in non-asthmatics; CRC cis rs2204008 0.653 rs11182569 chr12:38572452 G/A cg26384229 chr12:38710491 ALG10B 0.71 9.46 0.46 5.91e-19 Bladder cancer; CRC cis rs9478638 0.507 rs2184406 chr6:155629678 T/C cg06694381 chr6:155569200 TIAM2 -0.47 -6.14 -0.32 2.37e-9 Electroencephalogram traits; CRC cis rs2645694 0.626 rs904050 chr4:77826089 T/G cg03477792 chr4:77819574 ANKRD56 0.47 6.76 0.35 6.35e-11 Emphysema distribution in smoking; CRC cis rs7677751 0.806 rs4864861 chr4:55097685 C/T cg13615338 chr4:55094005 PDGFRA 0.4 5.83 0.31 1.35e-8 Corneal astigmatism; CRC cis rs4713118 0.955 rs9380011 chr6:27683924 A/G cg12172441 chr6:28176163 NA 0.47 6.19 0.32 1.75e-9 Parkinson's disease; CRC cis rs7044106 0.762 rs10984972 chr9:123409864 T/C cg14255062 chr9:123606675 PSMD5;LOC253039 0.43 6.59 0.34 1.73e-10 Hip circumference adjusted for BMI; CRC cis rs6754311 0.731 rs309160 chr2:136685228 C/T cg15123519 chr2:136567270 LCT -0.33 -6.32 -0.33 8.57e-10 Mosquito bite size; CRC cis rs801193 0.548 rs2659891 chr7:66201114 A/G cg12463550 chr7:65579703 CRCP 0.45 6.11 0.32 2.74e-9 Aortic root size; CRC cis rs7224685 0.501 rs11652060 chr17:4010412 A/T cg21851534 chr17:3907994 ZZEF1 -0.39 -6.48 -0.34 3.36e-10 Type 2 diabetes; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg06236748 chr11:71935846 INPPL1 0.48 6.73 0.35 7.58e-11 Response to antipsychotic treatment; CRC cis rs11758351 0.660 rs55848726 chr6:26224434 T/C cg22723502 chr6:26240528 HIST1H4F -0.36 -5.85 -0.31 1.17e-8 Gout;Renal underexcretion gout; CRC cis rs11864453 0.647 rs3764311 chr16:72125617 C/G cg23815491 chr16:72088622 HP 0.51 7.65 0.39 2.3e-13 Fibrinogen levels; CRC cis rs9399135 0.967 rs9376075 chr6:135296963 A/G cg24558204 chr6:135376177 HBS1L 0.5 7.82 0.4 7.14e-14 Red blood cell count; CRC cis rs6912958 0.525 rs242262 chr6:88018057 A/C cg04972856 chr6:88032051 C6orf162;GJB7 0.32 5.94 0.31 7.27e-9 Monocyte percentage of white cells; CRC cis rs2108225 0.872 rs4618632 chr7:107440952 T/G cg18560240 chr7:107437656 SLC26A3 -0.63 -9.38 -0.46 1.14e-18 Ulcerative colitis; CRC cis rs17155006 0.655 rs93619 chr7:107726833 C/T cg05962710 chr7:107745446 LAMB4 -0.35 -5.76 -0.3 1.92e-8 Pneumococcal bacteremia; CRC cis rs10504229 0.610 rs6987118 chr8:58147851 G/T cg22535103 chr8:58192502 C8orf71 -0.68 -9.66 -0.47 1.3e-19 Developmental language disorder (linguistic errors); CRC cis rs9517320 0.935 rs9645891 chr13:99126800 A/G cg07423050 chr13:99094983 FARP1 0.41 6.6 0.34 1.69e-10 Longevity; CRC cis rs4481887 0.893 rs10888348 chr1:248448610 C/G cg13385794 chr1:248469461 NA 0.37 6.56 0.34 2.14e-10 Common traits (Other); CRC trans rs4295623 0.531 rs2898295 chr8:11595969 C/T cg06636001 chr8:8085503 FLJ10661 -0.53 -8.15 -0.41 7.52e-15 Morning vs. evening chronotype; CRC trans rs12599106 0.792 rs76039834 chr16:34598453 G/A cg01516881 chr6:292596 DUSP22 -0.57 -8.38 -0.42 1.52e-15 Menopause (age at onset); CRC cis rs10782582 0.593 rs79552201 chr1:76215497 A/T cg03433033 chr1:76189801 ACADM -0.46 -6.65 -0.34 1.21e-10 Daytime sleep phenotypes; CRC cis rs477692 0.837 rs543454 chr10:131420536 T/C cg26102564 chr10:131424627 MGMT 0.38 5.63 0.3 3.9e-8 Response to temozolomide; CRC cis rs9814567 1.000 rs28409322 chr3:134252385 T/C cg06109529 chr3:134205091 CEP63;ANAPC13 0.82 12.06 0.55 5.69e-28 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC trans rs208520 0.690 rs4618506 chr6:66756889 A/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.99 -14.03 -0.61 2.33e-35 Exhaled nitric oxide output; CRC cis rs1580019 0.961 rs4460271 chr7:32496503 T/C cg07520158 chr7:32535189 LSM5;AVL9 0.45 6.48 0.34 3.4e-10 Cognitive ability; CRC cis rs9372498 0.505 rs4416700 chr6:118975461 G/C cg18833306 chr6:118973337 C6orf204 0.45 5.63 0.3 3.95e-8 Diastolic blood pressure; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg22926526 chr14:31028192 G2E3 0.37 5.97 0.31 6.27e-9 Liver disease severity in Alagille syndrome; CRC cis rs9818758 0.607 rs35283189 chr3:49113668 T/C cg07636037 chr3:49044803 WDR6 -0.82 -6.67 -0.35 1.06e-10 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; CRC cis rs11673344 0.583 rs10421436 chr19:37885503 T/C cg11669319 chr19:37771680 NA -0.41 -5.78 -0.3 1.73e-8 Obesity-related traits; CRC cis rs10504229 0.683 rs16921831 chr8:58111142 G/A cg02290350 chr8:58132656 NA -0.6 -8.3 -0.42 2.8e-15 Developmental language disorder (linguistic errors); CRC cis rs7089973 0.604 rs12218498 chr10:116578489 T/C cg23260525 chr10:116636907 FAM160B1 0.35 7.96 0.4 2.78e-14 Bipolar disorder or attention deficit hyperactivity disorder; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg18679712 chr3:14989672 NR2C2 0.42 6.35 0.33 7.3e-10 Intelligence (multi-trait analysis); CRC cis rs7727544 0.571 rs12521097 chr5:131575338 G/A cg22638593 chr5:131593259 PDLIM4 0.32 6.02 0.32 4.54e-9 Blood metabolite levels; CRC cis rs9488822 0.636 rs10872142 chr6:116369052 C/A cg18764771 chr6:116381957 FRK 0.24 6.97 0.36 1.77e-11 Cholesterol, total;LDL cholesterol; CRC cis rs736408 0.570 rs11130327 chr3:52793239 A/G cg11645453 chr3:52864694 ITIH4 0.36 6.26 0.33 1.17e-9 Bipolar disorder; CRC cis rs2304069 1.000 rs2304069 chr5:149406733 G/T cg22760475 chr5:149380129 HMGXB3;TIGD6 0.81 9.48 0.46 5.4e-19 HIV-1 control; CRC cis rs478304 0.593 rs2236682 chr11:65480090 G/T cg27068330 chr11:65405492 SIPA1 -0.65 -9.68 -0.47 1.12e-19 Acne (severe); CRC cis rs6743376 0.556 rs2515398 chr2:113819334 A/C cg24553058 chr2:113831203 IL1F10 0.43 6.96 0.36 1.81e-11 Inflammatory biomarkers; CRC cis rs9487051 0.714 rs6930733 chr6:109631587 T/C cg21918786 chr6:109611834 NA -0.39 -6.85 -0.35 3.7e-11 Reticulocyte fraction of red cells; CRC cis rs910316 1.000 rs4899546 chr14:75594946 G/C cg08847533 chr14:75593920 NEK9 0.95 18.47 0.71 8.95e-53 Height; CRC cis rs9783347 1.000 rs4150655 chr11:18375164 A/T cg15585147 chr11:18324498 HPS5 -0.44 -6.25 -0.33 1.28e-9 Pancreatic cancer; CRC cis rs4819052 0.851 rs8131143 chr21:46671646 C/G cg11663144 chr21:46675770 NA 0.85 14.91 0.63 9.19e-39 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs7762018 0.607 rs78941587 chr6:170061157 G/C cg24289452 chr6:170231220 NA -0.78 -6.96 -0.36 1.86e-11 Thiazide-induced adverse metabolic effects in hypertensive patients; CRC cis rs1552244 0.938 rs56274701 chr3:10167790 G/A cg13047869 chr3:10149882 C3orf24 0.56 7.6 0.39 3.07e-13 Alzheimer's disease; CRC cis rs7618915 0.547 rs2118540 chr3:52629386 T/C cg15147215 chr3:52552868 STAB1 -0.62 -10.22 -0.49 1.8e-21 Bipolar disorder; CRC cis rs8060686 0.641 rs1125331 chr16:68228119 T/C cg08314208 chr16:67682810 RLTPR -0.49 -5.79 -0.3 1.65e-8 HDL cholesterol;Metabolic syndrome; CRC cis rs10504229 1.000 rs117231141 chr8:58185465 A/G cg02290350 chr8:58132656 NA -0.42 -5.96 -0.31 6.62e-9 Developmental language disorder (linguistic errors); CRC cis rs10751667 0.666 rs10794354 chr11:954615 A/T cg01483505 chr11:975446 AP2A2 0.45 7.44 0.38 9.1e-13 Alzheimer's disease (late onset); CRC cis rs2976388 0.578 rs13263987 chr8:143827387 A/C cg12516270 chr8:143859308 LYNX1 -0.4 -6.23 -0.33 1.39e-9 Urinary tract infection frequency; CRC cis rs9322193 0.923 rs12195866 chr6:150014470 A/G cg07701084 chr6:150067640 NUP43 0.47 6.71 0.35 8.37e-11 Lung cancer; CRC cis rs6867032 0.687 rs4998338 chr5:2015910 A/G cg26168224 chr5:2018326 NA 1.0 18.55 0.71 4.56e-53 Gut microbiome composition (winter); CRC cis rs10743315 0.732 rs17271857 chr12:19458136 C/T cg02471346 chr12:19282374 PLEKHA5 -0.66 -6.31 -0.33 8.99e-10 Gut microbiota (bacterial taxa); CRC cis rs11098499 0.909 rs28581362 chr4:120283548 T/A cg24375607 chr4:120327624 NA 0.48 7.48 0.38 6.72e-13 Corneal astigmatism; CRC cis rs924607 0.898 rs1697990 chr5:626278 A/G cg09021430 chr5:549028 NA 0.5 8.31 0.42 2.58e-15 Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia; CRC cis rs7258465 0.965 rs271622 chr19:18629277 A/G cg06462663 chr19:18546047 ISYNA1 0.52 7.94 0.4 3.13e-14 Breast cancer; CRC cis rs7191439 0.858 rs6500489 chr16:88772046 T/C cg27087555 chr16:88793112 FAM38A -1.38 -11.24 -0.53 4.91e-25 Plateletcrit; CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg04132851 chr1:85155548 SSX2IP -0.49 -6.05 -0.32 3.89e-9 Diisocyanate-induced asthma; CRC cis rs72627123 0.867 rs73301479 chr14:74467757 G/A cg12022184 chr14:74485813 ENTPD5;C14orf45 0.71 5.92 0.31 8.3e-9 Morning vs. evening chronotype; CRC cis rs3858526 0.959 rs11039699 chr11:5951091 G/A cg26762873 chr11:5879799 OR52E8 -0.4 -5.88 -0.31 1.01e-8 DNA methylation (variation); CRC cis rs2280018 0.526 rs2966128 chr16:15153389 G/T cg27102117 chr16:15229624 NA 0.48 7.86 0.4 5.42e-14 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid);Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CRC cis rs875971 0.520 rs12666485 chr7:65625122 T/C cg02869306 chr7:64672164 INTS4L1 -0.43 -6.18 -0.32 1.86e-9 Aortic root size; CRC cis rs4713118 0.826 rs2893929 chr6:27738732 A/T cg12273811 chr6:28175739 NA 0.51 5.71 0.3 2.51e-8 Parkinson's disease; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg17145281 chr11:62420267 INTS5 0.47 6.62 0.34 1.47e-10 Response to antipsychotic treatment; CRC cis rs10876993 0.890 rs812304 chr12:58074853 A/C cg18357645 chr12:58087776 OS9 0.6 8.3 0.42 2.66e-15 Celiac disease or Rheumatoid arthritis; CRC cis rs3741404 0.757 rs2282492 chr11:63918589 A/G cg18225595 chr11:63971243 STIP1 0.65 10.64 0.51 6.48e-23 Platelet count; CRC cis rs7586879 1.000 rs10207698 chr2:25117672 C/T cg04586622 chr2:25135609 ADCY3 -0.43 -7.19 -0.37 4.46e-12 Body mass index; CRC cis rs11792861 0.816 rs3818932 chr9:111664178 T/C cg05043794 chr9:111880884 C9orf5 -0.32 -5.85 -0.31 1.16e-8 Menarche (age at onset); CRC cis rs9648716 1.000 rs2706774 chr7:140538127 C/T cg10747023 chr7:140774559 NA 0.44 5.76 0.3 1.94e-8 Type 2 diabetes; CRC cis rs1878931 0.582 rs4785933 chr16:3419741 T/A cg26668626 chr16:3451006 ZNF174;ZNF434 0.55 6.76 0.35 6.23e-11 Body mass index (adult); CRC cis rs13108904 0.901 rs12641735 chr4:1304434 G/C cg20887711 chr4:1340912 KIAA1530 0.43 6.14 0.32 2.41e-9 Obesity-related traits; CRC cis rs2019137 0.560 rs4849179 chr2:113985170 C/T cg12889195 chr2:113992843 PAX8;LOC440839;LOC654433 0.64 9.93 0.48 1.67e-20 Lymphocyte counts; CRC cis rs1552244 0.882 rs13077641 chr3:10022935 G/A cg18598329 chr3:10140678 FANCD2;C3orf24 -0.81 -10.69 -0.51 4.18e-23 Alzheimer's disease; CRC cis rs1023500 0.596 rs133369 chr22:42463814 C/T cg25452165 chr22:42524984 CYP2D6 0.43 6.51 0.34 2.88e-10 Schizophrenia; CRC cis rs7666738 0.830 rs7686456 chr4:99019695 T/C cg17366294 chr4:99064904 C4orf37 0.43 7.29 0.37 2.28e-12 Colonoscopy-negative controls vs population controls; CRC cis rs10504229 0.593 rs79615400 chr8:57988740 C/T cg24829409 chr8:58192753 C8orf71 -0.53 -6.22 -0.32 1.5e-9 Developmental language disorder (linguistic errors); CRC cis rs1707322 1.000 rs10890382 chr1:46469674 A/G cg03146154 chr1:46216737 IPP 0.55 7.51 0.38 5.73e-13 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs9443645 0.869 rs10943609 chr6:79676328 A/T cg11833968 chr6:79620685 NA -0.37 -6.27 -0.33 1.16e-9 Intelligence (multi-trait analysis); CRC cis rs13256369 0.802 rs4840350 chr8:8561442 A/G cg06636001 chr8:8085503 FLJ10661 0.48 6.1 0.32 2.99e-9 Obesity-related traits; CRC cis rs6502050 0.799 rs7406257 chr17:80089340 G/A cg25804541 chr17:80189381 SLC16A3 -0.3 -5.84 -0.31 1.24e-8 Life satisfaction; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg03901462 chr11:62572874 NXF1 -0.44 -6.51 -0.34 2.75e-10 Myopia (pathological); CRC cis rs4073582 0.555 rs521109 chr11:66030948 G/A cg16950941 chr11:66035639 RAB1B 0.71 12.12 0.56 3.47e-28 Gout; CRC cis rs875971 0.505 rs1723275 chr7:65504633 G/C cg11764359 chr7:65958608 NA -0.53 -7.99 -0.4 2.27e-14 Aortic root size; CRC cis rs11030122 0.733 rs10835331 chr11:3957365 C/T cg18678763 chr11:4115507 RRM1 -0.48 -7.98 -0.4 2.39e-14 Mean platelet volume;Platelet distribution width; CRC cis rs7809950 1.000 rs2808 chr7:107260856 A/G cg23024343 chr7:107201750 COG5 0.58 8.32 0.42 2.39e-15 Coronary artery disease; CRC cis rs796364 1.000 rs281759 chr2:200787719 T/C cg12253985 chr2:200820533 C2orf60;C2orf47 0.6 6.61 0.34 1.58e-10 Schizophrenia; CRC cis rs6540556 0.723 rs9430016 chr1:209916884 A/G cg23920097 chr1:209922102 NA -0.52 -6.53 -0.34 2.55e-10 Red blood cell count; CRC cis rs8014204 0.604 rs11625594 chr14:75389833 G/A cg03030879 chr14:75389066 RPS6KL1 -0.68 -11.38 -0.53 1.53e-25 Caffeine consumption; CRC cis rs72615157 0.634 rs74742883 chr7:99785765 T/G cg13153964 chr7:100026424 MEPCE;ZCWPW1 0.78 9.46 0.46 5.95e-19 Lung function (FEV1/FVC); CRC cis rs6496667 0.865 rs8035602 chr15:90909197 G/A cg04176472 chr15:90893244 GABARAPL3 0.6 8.21 0.41 5.11e-15 Rheumatoid arthritis; CRC cis rs9487051 0.676 rs6925716 chr6:109597641 T/C cg01475377 chr6:109611718 NA -0.37 -6.6 -0.34 1.68e-10 Reticulocyte fraction of red cells; CRC cis rs2396545 0.634 rs35788385 chr11:570094 G/A cg07212818 chr11:638076 DRD4 -0.48 -6.11 -0.32 2.81e-9 Systemic lupus erythematosus and Systemic sclerosis; CRC cis rs832540 0.695 rs702686 chr5:56201350 A/G cg24531977 chr5:56204891 C5orf35 -0.61 -9.2 -0.45 4.29e-18 Coronary artery disease; CRC cis rs9916302 0.904 rs35285898 chr17:37555872 A/C cg15445000 chr17:37608096 MED1 -0.43 -9.48 -0.46 5.3e-19 Glomerular filtration rate (creatinine); CRC cis rs9733 0.715 rs12402006 chr1:150869829 G/A cg15448220 chr1:150897856 SETDB1 -0.4 -5.75 -0.3 2.06e-8 Tonsillectomy; CRC cis rs4727963 0.792 rs12667916 chr7:122740976 A/G cg03640110 chr7:122635026 TAS2R16 0.35 6.33 0.33 8.19e-10 Adverse response to chemotherapy (neutropenia/leucopenia) (docetaxel); CRC cis rs79349575 0.783 rs62078370 chr17:47026836 G/C cg00947319 chr17:47005597 UBE2Z -0.33 -5.67 -0.3 3.11e-8 Type 2 diabetes; CRC cis rs6502050 0.871 rs8080366 chr17:80067298 A/G cg19223190 chr17:80058835 NA -0.45 -6.98 -0.36 1.64e-11 Life satisfaction; CRC cis rs2727020 0.521 rs11040408 chr11:49534880 A/T cg27395922 chr11:50257633 LOC441601 0.35 5.74 0.3 2.16e-8 Coronary artery disease; CRC cis rs7208859 0.673 rs73265612 chr17:29225983 A/G cg14008862 chr17:28927542 LRRC37B2 0.55 5.75 0.3 2.04e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs7552404 0.727 rs2172507 chr1:76331320 A/G cg22875332 chr1:76189707 ACADM -0.47 -6.14 -0.32 2.4e-9 Blood metabolite levels;Acylcarnitine levels; CRC cis rs1760803 0.754 rs2340473 chr1:154225344 C/T cg26808167 chr1:154192205 UBAP2L;C1orf43 0.36 6.22 0.32 1.55e-9 Nicotine dependence; CRC cis rs6585424 1.000 rs61860025 chr10:81925554 G/T cg11900509 chr10:81946545 ANXA11 -0.76 -9.32 -0.46 1.78e-18 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs853679 0.517 rs9348797 chr6:28137533 G/C cg15845792 chr6:28175446 NA 1.04 13.89 0.61 7.67e-35 Depression; CRC cis rs10256972 0.577 rs4999286 chr7:1199506 C/G cg22907277 chr7:1156413 C7orf50 0.68 10.44 0.5 3.06e-22 Longevity;Endometriosis; CRC cis rs2228479 0.850 rs2239358 chr16:89827330 C/G cg06558623 chr16:89946397 TCF25 1.13 10.45 0.5 2.85e-22 Skin colour saturation; CRC trans rs9858542 0.953 rs6446272 chr3:49463287 G/A cg21582582 chr3:182698605 DCUN1D1 -0.51 -6.43 -0.33 4.37e-10 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs1552244 0.938 rs7652951 chr3:10063763 A/C cg08888203 chr3:10149979 C3orf24 0.69 9.69 0.47 1.04e-19 Alzheimer's disease; CRC cis rs4727027 0.866 rs2373438 chr7:148780287 C/A cg23583168 chr7:148888333 NA -0.88 -14.88 -0.63 1.18e-38 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC cis rs875971 1.000 rs778706 chr7:65860424 A/G cg18876405 chr7:65276391 NA 0.52 9.04 0.45 1.37e-17 Aortic root size; CRC cis rs2645694 0.626 rs2645709 chr4:77824474 G/A cg03477792 chr4:77819574 ANKRD56 0.46 6.83 0.35 4.22e-11 Emphysema distribution in smoking; CRC cis rs911555 0.519 rs8014069 chr14:104004311 A/C cg12935359 chr14:103987150 CKB -0.52 -7.76 -0.39 1.06e-13 Intelligence (multi-trait analysis); CRC cis rs9942416 0.650 rs2640646 chr5:74977458 A/T cg00601450 chr5:74908170 NA -0.41 -5.75 -0.3 2.08e-8 Age-related disease endophenotypes; CRC cis rs1552244 0.572 rs73117481 chr3:10160132 C/T cg13047869 chr3:10149882 C3orf24 0.54 6.49 0.34 3.1e-10 Alzheimer's disease; CRC cis rs6724607 1.000 rs6724607 chr2:191466532 C/T cg21644426 chr2:191273491 MFSD6 0.48 6.51 0.34 2.84e-10 Pulse pressure; CRC cis rs711830 1.000 rs2249131 chr2:177032095 C/T cg13092806 chr2:177043255 NA 0.73 8.76 0.43 1.07e-16 Serous invasive ovarian cancer;Epithelial ovarian cancer;Invasive epithelial ovarian cancer;Mucinous ovarian carcinoma;Low-grade serous and serous borderline ovarian cancer;Serous borderline ovarian cancer;High-grade serous ovarian cancer; CRC cis rs67311347 1.000 rs2305521 chr3:40429183 A/G cg24209194 chr3:40518798 ZNF619 0.42 6.42 0.33 4.76e-10 Renal cell carcinoma; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg16565832 chr11:16760091 C11orf58 0.39 6.41 0.33 4.91e-10 Liver disease severity in Alagille syndrome; CRC cis rs10905065 0.717 rs11254266 chr10:5750078 G/T cg11519256 chr10:5708881 ASB13 0.43 5.96 0.31 6.33e-9 Menopause (age at onset); CRC cis rs17253792 0.822 rs74935793 chr14:56143277 G/A cg01858014 chr14:56050164 KTN1 -0.88 -7.22 -0.37 3.55e-12 Putamen volume; CRC cis rs8072100 0.967 rs8074149 chr17:45583375 A/C cg25173405 chr17:45401733 C17orf57 0.45 7.11 0.37 7.11e-12 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs8141797 0.901 rs4822472 chr22:24468123 C/A cg20894457 chr22:24584366 SUSD2 -0.61 -7.43 -0.38 9.27e-13 Amyotrophic lateral sclerosis;Coronary artery disease; CRC cis rs10078 0.559 rs2037077 chr5:447226 A/G cg07599136 chr5:415885 AHRR 0.57 5.81 0.31 1.47e-8 Fat distribution (HIV); CRC cis rs9911578 0.967 rs2643124 chr17:56741672 T/C cg12560992 chr17:57184187 TRIM37 0.9 16.6 0.68 2.14e-45 Intelligence (multi-trait analysis); CRC cis rs12347191 0.500 rs1912998 chr9:100621386 T/C cg13688889 chr9:100608707 NA -0.47 -5.92 -0.31 8.27e-9 Orofacial clefts; CRC cis rs7932354 0.502 rs7118546 chr11:47087128 C/G cg19486271 chr11:47235900 DDB2 -0.45 -6.58 -0.34 1.84e-10 Bone mineral density (hip);Bone mineral density; CRC cis rs60843830 1.000 rs11553746 chr2:272203 C/T cg25945732 chr2:264204 ACP1;SH3YL1 0.73 11.83 0.55 3.68e-27 Spherical equivalent (joint analysis main effects and education interaction); CRC cis rs7666738 0.830 rs7662199 chr4:99019766 G/A cg05340658 chr4:99064831 C4orf37 0.59 8.92 0.44 3.3e-17 Colonoscopy-negative controls vs population controls; CRC cis rs10484885 0.775 rs17584945 chr6:90512776 T/C cg13799429 chr6:90582589 CASP8AP2 -0.72 -7.79 -0.39 8.94e-14 QRS interval (sulfonylurea treatment interaction); CRC cis rs12142240 0.698 rs6659228 chr1:46811027 C/G cg00530320 chr1:46809349 NSUN4 0.6 8.15 0.41 7.55e-15 Menopause (age at onset); CRC cis rs9039 1.000 rs17567434 chr16:9221447 C/G cg08831531 chr16:9218945 NA -0.55 -7.0 -0.36 1.48e-11 Menopause (age at onset); CRC cis rs7043114 0.525 rs10820964 chr9:95041636 G/A cg14631576 chr9:95140430 CENPP -0.3 -5.76 -0.3 1.92e-8 Height; CRC cis rs10504229 0.645 rs6995814 chr8:58114159 C/T cg04204079 chr8:58130323 NA -0.45 -5.84 -0.31 1.27e-8 Developmental language disorder (linguistic errors); CRC cis rs9311474 0.629 rs7639267 chr3:52568805 G/T cg08222913 chr3:52553049 STAB1 -0.43 -8.78 -0.44 9.42e-17 Electroencephalogram traits; CRC cis rs6738485 0.601 rs13011900 chr2:106845059 G/C cg16099169 chr2:106886729 NA -0.38 -6.56 -0.34 2.06e-10 Pursuit maintenance gain;Pursuit maintenance gain in psychotic disorders; CRC trans rs2727020 0.521 rs11040408 chr11:49534880 A/T cg11707556 chr5:10655725 ANKRD33B 0.47 7.75 0.39 1.15e-13 Coronary artery disease; CRC cis rs9911578 1.000 rs2567911 chr17:56734977 A/G cg12560992 chr17:57184187 TRIM37 0.91 16.63 0.68 1.66e-45 Intelligence (multi-trait analysis); CRC cis rs3862030 0.839 rs12570859 chr10:104257226 C/T cg11453585 chr10:104263688 ACTR1A;SUFU -0.77 -13.34 -0.59 9.15e-33 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for body mass index; CRC cis rs853679 0.517 rs9295758 chr6:28120663 C/G cg15845792 chr6:28175446 NA 1.04 13.89 0.61 7.67e-35 Depression; CRC trans rs12517041 0.935 rs10053181 chr5:23293265 A/C ch.8.1293020R chr8:59333349 UBXN2B -0.55 -6.17 -0.32 2.05e-9 Calcium levels; CRC cis rs4713118 0.662 rs149969 chr6:27977737 A/G cg02683197 chr6:28174875 NA 0.71 9.8 0.48 4.55e-20 Parkinson's disease; CRC cis rs6424115 0.830 rs2501423 chr1:24199026 A/C cg09473613 chr1:24152604 HMGCL 0.35 5.67 0.3 3.09e-8 Immature fraction of reticulocytes; CRC cis rs2404602 0.669 rs12916324 chr15:77179603 G/A cg22467129 chr15:76604101 ETFA -0.38 -6.07 -0.32 3.61e-9 Blood metabolite levels; CRC trans rs6550704 0.687 rs9865314 chr3:22634337 A/G cg08188903 chr14:100680826 NA -0.41 -6.01 -0.31 4.89e-9 Daytime sleep phenotypes; CRC cis rs7119 0.635 rs907374 chr15:77884026 C/T cg27398640 chr15:77910606 LINGO1 0.44 7.97 0.4 2.61e-14 Type 2 diabetes; CRC cis rs9463078 0.608 rs6925017 chr6:44950828 T/C cg25276700 chr6:44698697 NA -0.25 -6.02 -0.31 4.75e-9 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; CRC cis rs2456568 0.548 rs10765647 chr11:93662459 T/C cg26875233 chr11:93583750 C11orf90 -0.36 -6.86 -0.35 3.39e-11 Response to serotonin reuptake inhibitors in major depressive disorder; CRC cis rs853679 0.550 rs1225598 chr6:28160799 T/G cg03623178 chr6:28175578 NA 1.0 15.19 0.64 7.35e-40 Depression; CRC cis rs910316 0.763 rs1548807 chr14:75479582 T/G cg03030879 chr14:75389066 RPS6KL1 -0.43 -6.73 -0.35 7.72e-11 Height; CRC cis rs67478160 0.634 rs2024669 chr14:104275602 G/C cg01849466 chr14:104193079 ZFYVE21 -0.53 -9.84 -0.48 3.4e-20 Schizophrenia; CRC cis rs968567 0.906 rs61897793 chr11:61599347 G/A cg19610905 chr11:61596333 FADS2 -0.62 -7.17 -0.37 5.07e-12 Blood metabolite levels;Rheumatoid arthritis;Vitiligo;Glycerophospholipid levels; CRC trans rs9291683 0.530 rs6449196 chr4:9973660 C/T cg26043149 chr18:55253948 FECH -0.53 -8.2 -0.41 5.61e-15 Bone mineral density; CRC cis rs6570726 0.791 rs11155432 chr6:145898761 T/C cg23711669 chr6:146136114 FBXO30 0.69 11.52 0.54 4.94e-26 Lobe attachment (rater-scored or self-reported); CRC cis rs3902035 1.000 rs3902035 chr6:119000232 T/C cg01339444 chr6:118972232 C6orf204 0.44 5.61 0.3 4.4e-8 QT interval; CRC cis rs7647973 1.000 rs13322887 chr3:49555583 G/A cg07690219 chr3:49449608 TCTA;RHOA 0.53 5.98 0.31 5.69e-9 Menarche (age at onset); CRC cis rs10463316 0.817 rs3846713 chr5:150799739 C/T cg03212797 chr5:150827313 SLC36A1 -0.53 -8.2 -0.41 5.42e-15 Metabolite levels (Pyroglutamine); CRC trans rs656319 0.559 rs17689037 chr8:9974858 C/T cg08975724 chr8:8085496 FLJ10661 -0.4 -5.98 -0.31 5.74e-9 Myopia (pathological); CRC cis rs644799 1.000 rs680134 chr11:95559517 T/C cg03916912 chr11:95522834 CEP57;FAM76B 0.95 18.39 0.71 1.94e-52 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs1552244 1.000 rs7622966 chr3:10139833 C/T cg10729496 chr3:10149963 C3orf24 0.49 6.78 0.35 5.57e-11 Alzheimer's disease; CRC cis rs10504229 0.645 rs6995814 chr8:58114159 C/T cg24829409 chr8:58192753 C8orf71 -0.54 -7.88 -0.4 4.9e-14 Developmental language disorder (linguistic errors); CRC cis rs72781680 0.768 rs112139157 chr2:24150783 A/C cg08917208 chr2:24149416 ATAD2B 0.55 6.68 0.35 1.03e-10 Lymphocyte counts; CRC cis rs9399135 0.967 rs7750300 chr6:135350950 C/G cg22676075 chr6:135203613 NA 0.42 6.41 0.33 5.16e-10 Red blood cell count; CRC cis rs561341 1.000 rs55736640 chr17:30333848 G/A cg23018236 chr17:30244563 NA -0.67 -8.0 -0.4 2.13e-14 Hip circumference adjusted for BMI; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg17597744 chr8:53627099 RB1CC1 0.42 7.05 0.36 1.05e-11 Liver disease severity in Alagille syndrome; CRC cis rs2032447 0.765 rs6942072 chr6:26014987 A/G cg04800585 chr6:26043546 HIST1H2BB 0.56 8.52 0.42 6.02e-16 Intelligence (multi-trait analysis); CRC cis rs75804782 0.641 rs2340870 chr2:239356026 C/T cg18131467 chr2:239335373 ASB1 -0.69 -6.17 -0.32 1.99e-9 Morning vs. evening chronotype;Chronotype; CRC trans rs4942242 0.663 rs9525816 chr13:44223898 A/G cg26741380 chr15:41871084 TYRO3 -0.46 -6.54 -0.34 2.4e-10 Response to tocilizumab in rheumatoid arthritis; CRC cis rs2276314 0.857 rs4799409 chr18:33592602 C/T cg05985134 chr18:33552581 C18orf21 0.45 6.2 0.32 1.7e-9 Endometriosis;Drug-induced torsades de pointes; CRC cis rs1499614 1.000 rs1267818 chr7:66107024 C/T cg12463550 chr7:65579703 CRCP 0.65 5.83 0.31 1.34e-8 Gout; CRC cis rs853679 0.517 rs3757185 chr6:28107776 T/A cg21251018 chr6:28226885 NKAPL 0.48 6.33 0.33 7.86e-10 Depression; CRC trans rs7615952 0.932 rs13314869 chr3:125644669 G/A cg16558177 chr4:4109446 NA -0.48 -6.19 -0.32 1.84e-9 Blood pressure (smoking interaction); CRC cis rs9549260 0.848 rs966968 chr13:41248037 C/T cg21288729 chr13:41239152 FOXO1 -0.48 -7.42 -0.38 1.01e-12 Red blood cell count; CRC trans rs10504229 1.000 rs17216620 chr8:58169412 A/G cg04077850 chr5:125800366 GRAMD3 0.38 6.44 0.33 4.14e-10 Developmental language disorder (linguistic errors); CRC cis rs17092148 1.000 rs1884432 chr20:33342439 A/G cg08999081 chr20:33150536 PIGU 0.45 5.77 0.3 1.8e-8 Neuroticism; CRC cis rs6912958 1.000 rs6912958 chr6:88133315 G/A cg12350822 chr6:88032061 C6orf162;GJB7 -0.44 -8.58 -0.43 3.71e-16 Monocyte percentage of white cells; CRC cis rs6754311 0.681 rs4954493 chr2:136609975 T/C cg15123519 chr2:136567270 LCT 0.33 6.48 0.34 3.42e-10 Mosquito bite size; CRC cis rs2991971 0.901 rs11211122 chr1:45954650 C/T cg24296786 chr1:45957014 TESK2 0.53 7.62 0.39 2.82e-13 High light scatter reticulocyte count; CRC trans rs7618501 1.000 rs11130219 chr3:49752427 C/T cg21659725 chr3:3221576 CRBN -0.91 -17.84 -0.7 2.75e-50 Intelligence (multi-trait analysis); CRC cis rs6860806 0.507 rs272878 chr5:131671769 C/T cg20512303 chr5:131592959 PDLIM4 -0.41 -7.23 -0.37 3.3e-12 Breast cancer; CRC cis rs916888 0.821 rs415430 chr17:44859144 C/T cg15921436 chr17:44337874 NA -0.68 -7.81 -0.4 7.78e-14 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs1448094 0.506 rs61930640 chr12:86173333 T/C cg00310523 chr12:86230176 RASSF9 0.42 6.87 0.35 3.17e-11 Major depressive disorder; CRC cis rs9488822 0.676 rs11757115 chr6:116362619 C/T cg05304507 chr6:116381966 FRK 0.31 8.54 0.43 5.19e-16 Cholesterol, total;LDL cholesterol; CRC cis rs7552404 1.000 rs4949879 chr1:76237143 G/A cg10523679 chr1:76189770 ACADM 0.82 11.42 0.53 1.16e-25 Blood metabolite levels;Acylcarnitine levels; CRC cis rs12753569 0.720 rs4381138 chr1:76509783 G/A cg00791851 chr1:76518896 NA 0.38 6.83 0.35 4.15e-11 Personality dimensions; CRC cis rs1401999 0.898 rs9876143 chr3:183731362 C/G cg05044414 chr3:183734942 ABCC5 0.45 7.64 0.39 2.35e-13 Anterior chamber depth; CRC cis rs514406 0.893 rs512723 chr1:53343880 C/T cg24675658 chr1:53192096 ZYG11B 0.52 7.3 0.37 2.14e-12 Monocyte count; CRC cis rs9488822 0.676 rs7774952 chr6:116380909 A/G cg26893134 chr6:116381904 FRK 0.26 7.62 0.39 2.7e-13 Cholesterol, total;LDL cholesterol; CRC cis rs6120849 0.754 rs3746435 chr20:33587198 G/C cg08999081 chr20:33150536 PIGU 0.45 5.71 0.3 2.56e-8 Protein C levels; CRC cis rs6951245 0.938 rs113642700 chr7:1105654 C/T cg18402987 chr7:1209562 NA 0.67 7.18 0.37 4.78e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs6502050 0.805 rs62080003 chr17:80078957 C/T cg19223190 chr17:80058835 NA -0.39 -6.06 -0.32 3.63e-9 Life satisfaction; CRC cis rs17001868 0.568 rs9611314 chr22:40735798 C/G cg07138101 chr22:40742427 ADSL 0.59 7.84 0.4 6.24e-14 Mammographic density (dense area); CRC cis rs629535 0.773 rs686683 chr8:70070364 G/A cg26132723 chr8:70041827 NA 0.35 5.77 0.3 1.8e-8 Dupuytren's disease; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg15094104 chr5:133406808 NA 0.45 6.65 0.34 1.21e-10 Response to antipsychotic treatment; CRC cis rs10504229 0.728 rs77197419 chr8:58150879 C/A cg21724239 chr8:58056113 NA 0.62 8.38 0.42 1.51e-15 Developmental language disorder (linguistic errors); CRC cis rs6961069 0.745 rs1527479 chr7:80272568 C/T cg04458919 chr7:80252533 CD36 -0.37 -6.57 -0.34 1.97e-10 Platelet count; CRC cis rs11764590 0.950 rs55683212 chr7:2078855 G/C cg25834613 chr7:1915315 MAD1L1 -0.44 -6.41 -0.33 5.17e-10 Neuroticism; CRC cis rs55702914 0.628 rs56718086 chr2:198261596 A/G cg10820045 chr2:198174542 NA 0.32 5.72 0.3 2.35e-8 Major depression and alcohol dependence; CRC cis rs11764590 0.671 rs56226325 chr7:2078981 C/T cg23422044 chr7:1970798 MAD1L1 -0.54 -6.3 -0.33 9.6e-10 Neuroticism; CRC cis rs9399135 0.967 rs12527707 chr6:135324511 G/A cg24558204 chr6:135376177 HBS1L 0.51 8.13 0.41 9e-15 Red blood cell count; CRC cis rs7618915 0.571 rs6762457 chr3:52609157 G/A cg08222913 chr3:52553049 STAB1 -0.34 -6.3 -0.33 9.34e-10 Bipolar disorder; CRC cis rs7647973 0.696 rs7100 chr3:49053219 A/G cg20833759 chr3:49053208 WDR6;DALRD3 0.75 11.55 0.54 3.78e-26 Menarche (age at onset); CRC cis rs12541335 0.639 rs4871994 chr8:22206038 G/A cg26039829 chr8:22132926 PIWIL2 0.52 9.13 0.45 7.03e-18 Hypertriglyceridemia; CRC trans rs11098499 0.954 rs3733524 chr4:120423729 T/C cg25214090 chr10:38739885 LOC399744 0.64 9.62 0.47 1.88e-19 Corneal astigmatism; CRC cis rs344364 0.511 rs337286 chr16:1965719 C/T cg09830162 chr16:1889614 FAHD1;C16orf73 -0.75 -8.85 -0.44 5.57e-17 Glomerular filtration rate in chronic kidney disease; CRC cis rs826838 0.935 rs11169511 chr12:39175802 T/C cg26384229 chr12:38710491 ALG10B 0.69 9.62 0.47 1.83e-19 Heart rate; CRC cis rs780096 0.526 rs704795 chr2:27716494 G/A cg22903471 chr2:27725779 GCKR -0.37 -5.97 -0.31 6.05e-9 Total body bone mineral density; CRC cis rs1008375 0.966 rs6813375 chr4:17649499 T/G cg16339924 chr4:17578868 LAP3 0.55 7.28 0.37 2.41e-12 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs524281 0.731 rs10791841 chr11:65808587 T/C cg16950941 chr11:66035639 RAB1B -0.52 -5.77 -0.3 1.81e-8 Electroencephalogram traits; CRC cis rs8072100 0.934 rs9905583 chr17:45741016 C/T cg08085267 chr17:45401833 C17orf57 -0.66 -10.78 -0.51 2.02e-23 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs4819052 1.000 rs2297285 chr21:46705621 A/G cg19498844 chr21:46707878 POFUT2;LOC642852 -0.83 -10.58 -0.5 1e-22 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs67478160 0.643 rs12878868 chr14:104233725 G/A cg08213375 chr14:104286397 PPP1R13B 0.65 13.66 0.6 6.03e-34 Schizophrenia; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg24229819 chr17:41856238 DUSP3 0.48 6.7 0.35 8.9e-11 Response to antipsychotic treatment; CRC cis rs2404602 0.716 rs17364076 chr15:76760891 C/T cg22467129 chr15:76604101 ETFA -0.45 -7.63 -0.39 2.55e-13 Blood metabolite levels; CRC cis rs9322193 0.884 rs12528279 chr6:150072028 A/C cg05861140 chr6:150128134 PCMT1 -0.39 -6.26 -0.33 1.21e-9 Lung cancer; CRC cis rs35306767 0.953 rs35693858 chr10:979813 C/T cg20503657 chr10:835505 NA 0.84 10.36 0.5 5.83e-22 Eosinophil percentage of granulocytes; CRC cis rs9487051 1.000 rs9480924 chr6:109617070 T/C cg01475377 chr6:109611718 NA -0.44 -7.89 -0.4 4.44e-14 Reticulocyte fraction of red cells; CRC cis rs713477 0.967 rs7146170 chr14:55914054 G/C cg13175173 chr14:55914753 NA -0.52 -9.9 -0.48 2.06e-20 Pediatric bone mineral content (femoral neck); CRC trans rs2303319 0.504 rs12470743 chr2:162611202 G/A cg10498984 chr16:28874827 SH2B1 -0.73 -6.3 -0.33 9.75e-10 Cognitive function; CRC cis rs6460942 0.908 rs6978877 chr7:12232690 A/G cg06484146 chr7:12443880 VWDE -0.58 -6.05 -0.32 4.03e-9 Coronary artery disease; CRC cis rs8180040 0.726 rs7625070 chr3:47095518 A/G cg10298567 chr3:47292165 KIF9 -0.4 -6.47 -0.34 3.55e-10 Colorectal cancer; CRC cis rs9303280 0.806 rs9907088 chr17:38035116 G/A cg11212589 chr17:38028394 ZPBP2 0.43 8.03 0.4 1.71e-14 Self-reported allergy; CRC cis rs6951245 1.000 rs113146460 chr7:1105164 C/G cg20603222 chr7:1096387 C7orf50;GPR146 -0.73 -8.68 -0.43 1.92e-16 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs1577917 0.740 rs9450302 chr6:86289673 C/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A 0.58 7.93 0.4 3.39e-14 Response to antipsychotic treatment; CRC cis rs2019137 0.936 rs731834 chr2:113957198 A/C cg11763394 chr2:113992921 PAX8;LOC440839;LOC654433 -0.5 -7.08 -0.36 8.77e-12 Lymphocyte counts; CRC cis rs10504073 0.584 rs115370638 chr8:49916452 A/G cg00325661 chr8:49890786 NA 0.63 11.42 0.53 1.14e-25 Blood metabolite ratios; CRC cis rs4665809 0.590 rs35532350 chr2:26441605 T/C cg04944784 chr2:26401820 FAM59B -0.83 -10.74 -0.51 2.96e-23 Gut microbiome composition (summer); CRC cis rs10751667 0.643 rs10902234 chr11:935578 A/G cg23136738 chr11:925521 AP2A2 -0.42 -6.98 -0.36 1.65e-11 Alzheimer's disease (late onset); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg01466967 chr5:59995837 DEPDC1B 0.41 6.1 0.32 2.92e-9 Intelligence (multi-trait analysis); CRC cis rs6502050 0.777 rs11077969 chr17:80085633 A/G cg02741985 chr17:80059408 CCDC57 -0.44 -7.15 -0.37 5.61e-12 Life satisfaction; CRC cis rs7615952 0.599 rs6438953 chr3:125724951 T/C cg18479299 chr3:125709523 NA -0.49 -6.44 -0.33 4.17e-10 Blood pressure (smoking interaction); CRC cis rs1814175 0.529 rs1988417 chr11:49932430 A/G cg25886479 chr11:50257625 LOC441601 -0.38 -6.76 -0.35 6.18e-11 Height; CRC cis rs9435341 0.930 rs12408634 chr1:107579540 G/A cg14828511 chr1:107599125 PRMT6 0.55 7.54 0.38 4.58e-13 Facial morphology (factor 21, depth of nasal alae); CRC cis rs909341 0.629 rs3761124 chr20:62288752 T/C cg16989086 chr20:62203971 PRIC285 -0.5 -6.48 -0.34 3.44e-10 Atopic dermatitis; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg05281544 chr6:21597055 SOX4 0.39 6.08 0.32 3.31e-9 Intelligence (multi-trait analysis); CRC cis rs2153535 0.563 rs1737584 chr6:8536742 C/T cg07606381 chr6:8435919 SLC35B3 0.69 11.32 0.53 2.59e-25 Motion sickness; CRC cis rs929354 0.742 rs3808316 chr7:156944787 C/G cg16102536 chr7:156981717 UBE3C 0.4 6.57 0.34 2.02e-10 Body mass index; CRC cis rs1881797 0.932 rs2387038 chr1:247674919 G/A cg21399703 chr1:247681439 NA 0.49 7.71 0.39 1.46e-13 Acute lymphoblastic leukemia (childhood); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg11928684 chr11:47291227 MADD 0.39 6.21 0.32 1.63e-9 Liver disease severity in Alagille syndrome; CRC cis rs394563 0.726 rs6922130 chr6:149672375 C/G cg03678062 chr6:149772716 ZC3H12D 0.35 6.42 0.33 4.71e-10 Dupuytren's disease; CRC cis rs10504229 0.639 rs56825757 chr8:58106469 A/G cg02725872 chr8:58115012 NA -0.66 -11.36 -0.53 1.85e-25 Developmental language disorder (linguistic errors); CRC trans rs2228479 0.850 rs11640209 chr16:89807828 C/A cg21302420 chr1:112162376 RAP1A 0.72 5.96 0.31 6.38e-9 Skin colour saturation; CRC trans rs1005277 0.579 rs9299760 chr10:38377920 C/T cg23533926 chr12:111358616 MYL2 -0.52 -7.83 -0.4 6.57e-14 Extrinsic epigenetic age acceleration; CRC cis rs911119 0.955 rs6048946 chr20:23602307 G/T cg16589663 chr20:23618590 CST3 0.47 6.5 0.34 2.92e-10 Chronic kidney disease; CRC cis rs9322193 1.000 rs9767077 chr6:150109615 T/A cg13206674 chr6:150067644 NUP43 0.57 8.14 0.41 8.29e-15 Lung cancer; CRC cis rs12476592 0.571 rs964903 chr2:63741548 C/T cg10828910 chr2:63850056 LOC388955 0.45 5.63 0.3 3.92e-8 Childhood ear infection; CRC cis rs1656402 1.000 rs1190442 chr2:233422205 A/C cg03852847 chr2:233439513 NA 0.42 7.15 0.37 5.72e-12 Non-small cell lung cancer (survival); CRC cis rs877282 1.000 rs10904552 chr10:774326 A/G cg17470449 chr10:769945 NA 0.63 9.05 0.45 1.26e-17 Uric acid levels; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg00269115 chr1:23695530 C1orf213;ZNF436 0.44 6.35 0.33 6.99e-10 Intelligence (multi-trait analysis); CRC cis rs7552404 0.731 rs11161857 chr1:76370228 G/C cg22875332 chr1:76189707 ACADM 0.64 7.84 0.4 6.51e-14 Blood metabolite levels;Acylcarnitine levels; CRC cis rs1552244 0.572 rs17032440 chr3:10169819 A/C cg18598329 chr3:10140678 FANCD2;C3orf24 0.86 10.21 0.49 1.99e-21 Alzheimer's disease; CRC cis rs3809863 0.602 rs11650072 chr17:45393665 A/G cg25173405 chr17:45401733 C17orf57 -0.64 -10.23 -0.49 1.65e-21 Glaucoma (primary open-angle); CRC cis rs137699 0.695 rs137653 chr22:39732171 A/G cg11247378 chr22:39784982 NA 0.31 5.84 0.31 1.25e-8 IgG glycosylation; CRC cis rs950169 0.920 rs12915390 chr15:84792069 T/C cg03959625 chr15:84868606 LOC388152 0.41 6.22 0.32 1.53e-9 Schizophrenia; CRC cis rs10504229 1.000 rs112272435 chr8:58170371 A/G cg02725872 chr8:58115012 NA -0.38 -6.43 -0.33 4.44e-10 Developmental language disorder (linguistic errors); CRC cis rs875971 0.862 rs2460432 chr7:65554385 C/T cg12463550 chr7:65579703 CRCP -0.54 -7.61 -0.39 2.95e-13 Aortic root size; CRC cis rs1564271 1.000 rs1564271 chr10:27011112 G/A cg13837822 chr10:26931731 LOC731789 0.48 6.64 0.34 1.27e-10 Overall survival in serous epithelial ovarian cancer treated with paclitaxel and cisplatin; CRC cis rs10946940 1.000 rs10946940 chr6:27560587 A/G cg06470822 chr6:28175283 NA -0.5 -6.94 -0.36 2.04e-11 Systemic lupus erythematosus; CRC cis rs12134245 0.776 rs13447526 chr1:91983174 A/G cg07090678 chr1:91966139 CDC7 -0.44 -6.89 -0.35 2.92e-11 Breast cancer; CRC cis rs7586879 0.593 rs10198356 chr2:25130592 A/G cg04586622 chr2:25135609 ADCY3 -0.55 -10.35 -0.5 6.63e-22 Body mass index; CRC cis rs10479542 0.896 rs4701131 chr5:178982446 A/G cg14820908 chr5:178986412 RUFY1 0.39 6.88 0.35 3.12e-11 Lung cancer; CRC cis rs9308731 0.623 rs2241842 chr2:111879415 A/G cg18646521 chr2:111875858 NA 0.36 5.69 0.3 2.84e-8 Chronic lymphocytic leukemia; CRC cis rs6582630 0.519 rs7305545 chr12:38349223 G/A cg26384229 chr12:38710491 ALG10B 0.69 9.79 0.48 4.92e-20 Drug-induced liver injury (flucloxacillin); CRC cis rs9462846 0.802 rs1819324 chr6:42859723 G/C cg21280719 chr6:42927975 GNMT -0.31 -5.81 -0.31 1.44e-8 Blood protein levels; CRC cis rs7249142 0.549 rs1858846 chr19:19281187 T/G cg26504305 chr19:19281019 LOC729991-MEF2B;MEF2B -0.45 -8.91 -0.44 3.63e-17 IgG glycosylation; CRC cis rs8062405 1.000 rs7498665 chr16:28883241 A/G cg08761264 chr16:28874980 SH2B1 -0.44 -5.83 -0.31 1.33e-8 Cognitive ability (multi-trait analysis);Cognitive ability; CRC cis rs10924970 0.870 rs12095886 chr1:235432249 A/G cg26050004 chr1:235667680 B3GALNT2 0.39 5.77 0.3 1.83e-8 Asthma; CRC cis rs16852403 0.583 rs6670912 chr1:178082410 C/T cg00404053 chr1:178313656 RASAL2 0.63 8.03 0.4 1.79e-14 Childhood ear infection; CRC cis rs6952808 0.723 rs57216949 chr7:2030287 G/T cg22963979 chr7:1858916 MAD1L1 -0.53 -7.67 -0.39 1.97e-13 Bipolar disorder and schizophrenia; CRC cis rs7666738 0.830 rs2865978 chr4:99017946 G/T cg05340658 chr4:99064831 C4orf37 0.61 9.51 0.46 4.05e-19 Colonoscopy-negative controls vs population controls; CRC cis rs2742417 0.609 rs11709306 chr3:45773732 G/A cg04837898 chr3:45731254 SACM1L -0.48 -7.69 -0.39 1.74e-13 Response to anti-depressant treatment in major depressive disorder; CRC cis rs12497850 0.829 rs8926 chr3:49052785 T/A cg20833759 chr3:49053208 WDR6;DALRD3 0.54 9.08 0.45 1.04e-17 Parkinson's disease; CRC cis rs1348850 0.914 rs4341974 chr2:178324879 A/C cg22681709 chr2:178499509 PDE11A -0.36 -6.7 -0.35 9.23e-11 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs9914544 0.966 rs9906795 chr17:18816740 G/A cg26378065 chr17:18585709 ZNF286B 0.41 5.8 0.3 1.59e-8 Educational attainment (years of education); CRC cis rs4689388 0.926 rs5018648 chr4:6292818 C/G cg25554036 chr4:6271136 WFS1 -0.54 -8.78 -0.44 9.19e-17 Type 2 diabetes and other traits;Type 2 diabetes; CRC cis rs1801251 1.000 rs3816334 chr2:233708806 A/G cg25237894 chr2:233734115 C2orf82 -0.54 -8.79 -0.44 8.63e-17 Coronary artery disease; CRC cis rs7394190 0.748 rs2075641 chr10:75562108 G/A cg07699608 chr10:75541558 CHCHD1 0.61 6.19 0.32 1.79e-9 Incident atrial fibrillation; CRC cis rs10991814 0.920 rs78978656 chr9:94090130 G/A cg14446406 chr9:93919335 NA 0.57 6.19 0.32 1.75e-9 Neutrophil percentage of granulocytes; CRC cis rs7589728 0.844 rs77144652 chr2:88496684 G/A cg04511125 chr2:88470314 THNSL2 0.74 7.27 0.37 2.58e-12 Plasma clusterin levels; CRC cis rs270601 0.837 rs367805 chr5:131701279 T/C cg18301423 chr5:131593218 PDLIM4 0.38 6.32 0.33 8.75e-10 Acylcarnitine levels; CRC cis rs853679 0.517 rs56310871 chr6:28044482 A/G cg25164649 chr6:28176230 NA 0.72 9.1 0.45 9.16e-18 Depression; CRC cis rs3862260 0.509 rs2281493 chr1:120162787 T/C cg11530693 chr1:120165357 ZNF697 0.61 9.81 0.48 4.33e-20 Systemic lupus erythematosus; CRC cis rs1183201 0.505 rs1165201 chr6:25874823 A/C cg03264133 chr6:25882463 NA -0.79 -11.97 -0.55 1.18e-27 Uric acid levels; CRC cis rs2836974 0.836 rs1041440 chr21:40627325 C/T cg17971929 chr21:40555470 PSMG1 0.84 12.03 0.55 6.88e-28 Cognitive function; CRC cis rs732505 0.618 rs1337057 chr19:5676950 G/A cg26242866 chr19:5711310 LONP1 0.68 6.69 0.35 9.36e-11 vWF and FVIII levels; CRC cis rs853679 0.517 rs4713137 chr6:28083521 C/G cg06470822 chr6:28175283 NA 1.0 13.06 0.58 1.06e-31 Depression; CRC cis rs12477438 0.501 rs11683188 chr2:99724512 T/C cg26064155 chr2:99771622 LIPT1;TSGA10 0.77 13.1 0.59 7.65e-32 Chronic sinus infection; CRC cis rs7385804 0.796 rs10277087 chr7:100307538 C/G cg16850897 chr7:100343110 ZAN 0.45 6.94 0.36 2.15e-11 Iron status biomarkers;Mean corpuscular hemoglobin;Hematocrit;Iron status biomarkers (transferrin saturation);Red blood cell count;Iron status biomarkers (iron levels);Mean corpuscular volume;Hematological parameters; CRC cis rs875971 1.000 rs778685 chr7:65836176 G/T cg00343986 chr7:65444356 GUSB 0.43 6.3 0.33 9.66e-10 Aortic root size; CRC cis rs17767392 0.958 rs12885344 chr14:72003224 G/A cg13720639 chr14:72061746 SIPA1L1 -0.57 -7.2 -0.37 4e-12 Mitral valve prolapse; CRC cis rs1799949 0.930 rs2298861 chr17:41176831 G/A cg01879757 chr17:41196368 BRCA1 -0.41 -6.07 -0.32 3.62e-9 Menopause (age at onset); CRC cis rs9287719 0.649 rs10188373 chr2:10718802 A/G cg00105475 chr2:10696890 NA 0.45 7.06 0.36 9.97e-12 Prostate cancer; CRC cis rs1580019 0.713 rs2122632 chr7:32524686 A/G cg07520158 chr7:32535189 LSM5;AVL9 -0.55 -7.82 -0.4 7.27e-14 Cognitive ability; CRC cis rs7811142 1.000 rs1073 chr7:100031612 G/A cg00814883 chr7:100076585 TSC22D4 -0.72 -8.89 -0.44 4e-17 Platelet count; CRC cis rs929354 0.772 rs1182362 chr7:157019535 A/G cg16102536 chr7:156981717 UBE3C -0.4 -6.73 -0.35 7.4e-11 Body mass index; CRC trans rs13046373 0.905 rs4816372 chr21:32077414 A/T cg21177558 chr8:27677755 PBK -0.37 -6.18 -0.32 1.92e-9 HDL cholesterol; CRC cis rs870825 0.929 rs1405940 chr4:185591481 A/G cg07424746 chr4:185654737 MLF1IP -0.59 -5.67 -0.3 3.09e-8 Blood protein levels; CRC cis rs11764590 0.694 rs10241537 chr7:2083358 A/G cg24505167 chr7:1915268 MAD1L1 -0.35 -5.73 -0.3 2.24e-8 Neuroticism; CRC trans rs12599106 0.770 rs12445057 chr16:34970274 C/G cg26668828 chr6:292823 DUSP22 -0.66 -9.83 -0.48 3.76e-20 Menopause (age at onset); CRC cis rs6684514 0.922 rs12047994 chr1:156284535 C/A cg16558208 chr1:156270281 VHLL 0.57 8.89 0.44 4.08e-17 Mean corpuscular hemoglobin concentration;Glycated hemoglobin levels; CRC cis rs950169 0.840 rs2896002 chr15:84945121 A/G cg17507749 chr15:85114479 UBE2QP1 0.74 10.59 0.5 9.91e-23 Schizophrenia; CRC cis rs720844 0.608 rs7592536 chr2:149346137 G/A cg09247360 chr2:149335327 NA 0.48 6.35 0.33 7.06e-10 Peripheral arterial disease (traffic-related air pollution interaction); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg12252801 chr9:127951667 PPP6C 0.44 6.19 0.32 1.76e-9 Response to antipsychotic treatment; CRC cis rs6951245 1.000 rs113146460 chr7:1105164 C/G cg04025307 chr7:1156635 C7orf50 0.66 7.09 0.36 8.05e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs7191439 0.728 rs4238687 chr16:88788903 T/G cg27087555 chr16:88793112 FAM38A -1.42 -13.38 -0.59 6.79e-33 Plateletcrit; CRC cis rs9916302 0.851 rs677888 chr17:37461018 T/G cg07936489 chr17:37558343 FBXL20 0.75 10.31 0.49 8.55e-22 Glomerular filtration rate (creatinine); CRC cis rs6543140 0.964 rs2141781 chr2:103082906 G/A cg04239558 chr2:103089729 SLC9A4 0.37 6.61 0.34 1.51e-10 Blood protein levels; CRC cis rs2637266 0.600 rs11001844 chr10:78405461 A/G cg18941641 chr10:78392320 NA 0.35 6.3 0.33 9.43e-10 Pulmonary function; CRC cis rs28386778 0.863 rs7221573 chr17:61859390 G/A cg25654072 chr17:61904446 PSMC5;FTSJ3 0.72 11.3 0.53 2.97e-25 Prudent dietary pattern; CRC cis rs9311676 0.586 rs11707019 chr3:58398036 A/C cg06643156 chr3:58380774 PXK 0.42 6.38 0.33 5.84e-10 Systemic lupus erythematosus; CRC trans rs2243480 1.000 rs35825738 chr7:65318027 A/G cg10756647 chr7:56101905 PSPH 0.73 7.72 0.39 1.46e-13 Diabetic kidney disease; CRC cis rs6570726 0.526 rs72994723 chr6:145722948 G/A cg23711669 chr6:146136114 FBXO30 -0.48 -7.95 -0.4 3.03e-14 Lobe attachment (rater-scored or self-reported); CRC cis rs947211 0.898 rs1772156 chr1:205752894 T/C cg14893161 chr1:205819251 PM20D1 0.41 5.63 0.3 3.91e-8 Parkinson's disease; CRC cis rs6582630 0.555 rs10880607 chr12:38508184 A/G cg13010199 chr12:38710504 ALG10B 0.46 5.88 0.31 9.81e-9 Drug-induced liver injury (flucloxacillin); CRC cis rs4900538 0.821 rs2009575 chr14:102820787 C/T cg18135206 chr14:102964638 TECPR2 -0.96 -17.02 -0.68 4.72e-47 Mean corpuscular volume;Mean corpuscular hemoglobin; CRC cis rs12188164 0.686 rs72711369 chr5:420517 C/T cg00976097 chr5:421733 AHRR -0.45 -6.01 -0.31 5.02e-9 Cystic fibrosis severity; CRC cis rs7192380 0.729 rs11648335 chr16:69597317 A/G cg00738113 chr16:70207722 CLEC18C -0.33 -5.71 -0.3 2.48e-8 Sjögren's syndrome; CRC trans rs10242455 0.867 rs15524 chr7:99245914 A/G cg09045935 chr12:6379348 NA 0.58 6.45 0.34 4.07e-10 Blood metabolite levels; CRC cis rs12190007 0.846 rs9505962 chr6:169726667 A/G cg16388071 chr6:169726476 NA 0.4 6.37 0.33 6.22e-10 Obesity-related traits; CRC cis rs9462027 1.000 rs9689160 chr6:34749849 A/G cg07306190 chr6:34760872 UHRF1BP1 -0.33 -5.6 -0.3 4.42e-8 Systemic lupus erythematosus; CRC cis rs12451471 0.559 rs12452263 chr17:78079310 T/C cg08347473 chr17:78092826 GAA -0.37 -6.3 -0.33 9.48e-10 Plateletcrit;Mean corpuscular hemoglobin concentration; CRC cis rs4974559 0.739 rs10029534 chr4:1322908 C/A cg02980000 chr4:1222292 CTBP1 0.77 8.44 0.42 1.01e-15 Systolic blood pressure; CRC cis rs7811142 1.000 rs11771419 chr7:99988403 A/G cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.61 7.84 0.4 6.33e-14 Platelet count; CRC cis rs7312933 0.618 rs6582394 chr12:42686189 A/G cg19980929 chr12:42632907 YAF2 0.45 6.78 0.35 5.48e-11 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CRC cis rs2228479 0.850 rs62054609 chr16:89816569 C/A cg06558623 chr16:89946397 TCF25 1.15 10.8 0.51 1.85e-23 Skin colour saturation; CRC cis rs2645694 0.626 rs2703126 chr4:77819842 T/C cg03477792 chr4:77819574 ANKRD56 0.44 6.37 0.33 6.51e-10 Emphysema distribution in smoking; CRC cis rs2281845 0.826 rs4915484 chr1:201076917 C/G cg24849736 chr1:201084428 NA 0.56 10.27 0.49 1.25e-21 Permanent tooth development; CRC cis rs2243480 1.000 rs464895 chr7:65527106 A/G cg25985355 chr7:65971099 NA -0.54 -6.0 -0.31 5.34e-9 Diabetic kidney disease; CRC cis rs12971120 0.891 rs12608037 chr18:72169395 A/G cg25817165 chr18:72167213 CNDP2 -0.64 -8.66 -0.43 2.11e-16 Refractive error; CRC cis rs737008 0.922 rs376374 chr16:11370616 G/A cg00044050 chr16:11439710 C16orf75 -0.46 -6.13 -0.32 2.55e-9 Obesity-related traits; CRC cis rs992157 0.560 rs4674274 chr2:219089131 A/T cg04731861 chr2:219085781 ARPC2 0.37 7.98 0.4 2.4e-14 Colorectal cancer; CRC cis rs4819052 0.851 rs2330012 chr21:46658592 G/A cg19498844 chr21:46707878 POFUT2;LOC642852 0.77 10.99 0.52 3.97e-24 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs501120 0.925 rs559469 chr10:44752118 C/T cg09554077 chr10:44749378 NA -0.87 -13.03 -0.58 1.41e-31 Coronary artery disease;Coronary heart disease; CRC cis rs10504229 0.683 rs10504224 chr8:58143735 A/G cg02290350 chr8:58132656 NA -0.59 -7.0 -0.36 1.47e-11 Developmental language disorder (linguistic errors); CRC cis rs2841277 0.708 rs11851053 chr14:105407208 T/C cg15352829 chr14:105391018 PLD4 -0.5 -10.94 -0.52 5.95e-24 Rheumatoid arthritis; CRC cis rs3790844 0.501 rs12035139 chr1:199951850 G/A cg07208853 chr1:200005219 NR5A2 0.34 9.01 0.45 1.66e-17 Pancreatic cancer; CRC cis rs10256972 0.591 rs6968988 chr7:1169619 A/G cg07092213 chr7:1199455 ZFAND2A -0.43 -6.38 -0.33 6.12e-10 Longevity;Endometriosis; CRC cis rs12999616 0.857 rs34459720 chr2:98325447 T/C cg26665480 chr2:98280029 ACTR1B 0.51 6.28 0.33 1.08e-9 Colorectal cancer; CRC trans rs7267979 0.844 rs4815413 chr20:25359229 G/T cg17903999 chr18:56338584 MALT1 0.42 6.68 0.35 1.05e-10 Liver enzyme levels (alkaline phosphatase); CRC cis rs6714710 0.603 rs13023980 chr2:98502987 T/C cg26665480 chr2:98280029 ACTR1B 0.53 7.36 0.38 1.53e-12 Posterior cortical atrophy and Alzheimer's disease; CRC cis rs7223966 1.000 rs3817181 chr17:61776538 G/C cg23090583 chr17:61904693 PSMC5;FTSJ3 0.55 6.71 0.35 8.62e-11 Hip circumference adjusted for BMI;Body mass index; CRC cis rs2153535 0.580 rs7341381 chr6:8470537 A/G cg21535247 chr6:8435926 SLC35B3 0.5 7.56 0.38 4.18e-13 Motion sickness; CRC cis rs898097 0.812 rs8065641 chr17:80820259 A/G cg16060761 chr17:80687452 NA 0.4 5.94 0.31 7.37e-9 Breast cancer; CRC cis rs951366 0.764 rs708724 chr1:205743663 A/C cg14159672 chr1:205819179 PM20D1 0.74 10.97 0.52 4.67e-24 Menarche (age at onset); CRC cis rs910316 1.000 rs12588240 chr14:75612083 C/A cg03030879 chr14:75389066 RPS6KL1 -0.45 -7.09 -0.36 8.43e-12 Height; CRC trans rs57506017 0.517 rs62435714 chr7:12254012 A/G cg26461140 chr11:72811902 FCHSD2 0.61 6.97 0.36 1.76e-11 Neuroticism; CRC cis rs1552244 1.000 rs7648104 chr3:10073311 C/A cg13047869 chr3:10149882 C3orf24 0.57 7.76 0.39 1.1e-13 Alzheimer's disease; CRC cis rs7772486 0.720 rs7752286 chr6:146072662 C/T cg23711669 chr6:146136114 FBXO30 -0.74 -12.59 -0.57 5.97e-30 Lobe attachment (rater-scored or self-reported); CRC cis rs7312933 0.645 rs12049942 chr12:42587052 G/A cg19980929 chr12:42632907 YAF2 0.44 6.57 0.34 2.01e-10 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CRC cis rs2944591 0.505 rs2592118 chr2:233792425 C/T cg11972305 chr2:233791962 NGEF -0.42 -6.63 -0.34 1.35e-10 Autism spectrum disorder or schizophrenia; CRC trans rs6076960 0.684 rs3852949 chr20:6264758 T/A cg17788362 chr6:86352627 SYNCRIP 0.55 7.73 0.39 1.35e-13 Smooth-surface caries; CRC cis rs17270561 0.609 rs4711100 chr6:25741954 G/A cg16482183 chr6:26056742 HIST1H1C 0.83 10.69 0.51 4.46e-23 Iron status biomarkers; CRC cis rs60871478 1.000 rs62432252 chr7:802886 C/G cg04727924 chr7:799746 HEATR2 -0.45 -6.64 -0.34 1.3e-10 Cerebrospinal P-tau181p levels; CRC cis rs12048904 0.512 rs932798 chr1:101249355 G/C cg00063077 chr1:101360652 SLC30A7;EXTL2 -0.68 -10.12 -0.49 3.77e-21 Multiple sclerosis; CRC cis rs7927592 0.871 rs113020558 chr11:68296832 G/A cg01657329 chr11:68192670 LRP5 -0.46 -6.55 -0.34 2.19e-10 Total body bone mineral density; CRC cis rs7589342 0.839 rs12997003 chr2:106436413 C/T cg16077055 chr2:106428750 NCK2 0.39 5.64 0.3 3.74e-8 Addiction; CRC cis rs1697139 0.935 rs1623654 chr5:66512819 A/T cg11553311 chr5:66541588 NA 0.48 8.12 0.41 9.49e-15 Breast cancer; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg12842013 chr14:23755227 HOMEZ 0.48 6.56 0.34 2.03e-10 Anxiety disorder; CRC cis rs10504229 0.593 rs17794451 chr8:58019217 C/T cg21724239 chr8:58056113 NA 0.77 9.81 0.48 4.41e-20 Developmental language disorder (linguistic errors); CRC cis rs9916302 0.784 rs34473775 chr17:37396201 G/T cg03013999 chr17:37608204 MED1 0.47 7.14 0.37 6.13e-12 Glomerular filtration rate (creatinine); CRC cis rs1801251 1.000 rs6724117 chr2:233593660 T/G cg25237894 chr2:233734115 C2orf82 0.54 8.77 0.44 9.91e-17 Coronary artery disease; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg18800192 chr19:42388471 ARHGEF1 0.4 6.44 0.33 4.33e-10 Liver disease severity in Alagille syndrome; CRC trans rs16846053 0.786 rs72873645 chr2:162495047 G/A cg01191114 chr3:48936118 SLC25A20 -0.67 -6.08 -0.32 3.35e-9 Blood osmolality (transformed sodium); CRC cis rs13108904 0.967 rs4974582 chr4:1279687 C/T cg16405210 chr4:1374714 KIAA1530 -0.44 -6.05 -0.32 3.92e-9 Obesity-related traits; CRC cis rs11785400 1.000 rs6988393 chr8:143740596 A/G cg10596483 chr8:143751796 JRK 0.49 6.94 0.36 2.06e-11 Schizophrenia; CRC cis rs1799949 1.000 rs8176233 chr17:41219804 T/C cg01879757 chr17:41196368 BRCA1 -0.43 -6.53 -0.34 2.56e-10 Menopause (age at onset); CRC trans rs916888 0.821 rs199504 chr17:44861003 C/T cg01341218 chr17:43662625 NA -0.82 -9.13 -0.45 7.35e-18 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC trans rs3960554 0.569 rs10464565 chr7:75869526 T/G cg19862616 chr7:65841803 NCRNA00174 0.55 7.87 0.4 5.3e-14 Eotaxin levels; CRC cis rs875971 0.862 rs778705 chr7:65861115 G/A cg18252515 chr7:66147081 NA -0.42 -5.99 -0.31 5.64e-9 Aortic root size; CRC cis rs4243830 0.510 rs7518459 chr1:6596678 C/G cg15205204 chr1:6545172 PLEKHG5 0.38 5.63 0.3 3.81e-8 Body mass index; CRC trans rs2303319 0.504 rs62187656 chr2:162487699 A/G cg04269497 chr6:167369491 RNASET2 -0.74 -6.05 -0.32 3.85e-9 Cognitive function; CRC cis rs1799949 1.000 rs11654452 chr17:41189383 G/T cg23758822 chr17:41437982 NA 0.8 13.18 0.59 3.91e-32 Menopause (age at onset); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg09368129 chr5:140071347 HARS2;HARS 0.43 5.97 0.31 6.23e-9 Response to antipsychotic treatment; CRC cis rs2408955 0.542 rs7975632 chr12:48443048 C/T cg21466736 chr12:48725269 NA -0.48 -7.36 -0.38 1.48e-12 Glycated hemoglobin levels; CRC cis rs9308731 0.563 rs11899831 chr2:111932694 G/A cg04202892 chr2:111875749 ACOXL 0.42 6.78 0.35 5.58e-11 Chronic lymphocytic leukemia; CRC trans rs747782 0.582 rs11039571 chr11:48207259 G/A cg03929089 chr4:120376271 NA 0.61 6.12 0.32 2.69e-9 Intraocular pressure; CRC cis rs60871478 0.635 rs4311567 chr7:792295 T/C cg05535760 chr7:792225 HEATR2 0.99 12.33 0.56 5.51e-29 Cerebrospinal P-tau181p levels; CRC cis rs13266463 0.898 rs13267784 chr8:143394915 C/T cg24996280 chr8:143481281 TSNARE1 0.36 5.9 0.31 8.84e-9 Schizophrenia; CRC trans rs7615952 0.512 rs2979351 chr3:125363599 C/T cg21747405 chr11:67723411 NA -0.59 -9.19 -0.45 4.46e-18 Blood pressure (smoking interaction); CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg02980631 chr6:157008350 NA -0.43 -6.63 -0.34 1.36e-10 Myopia (pathological); CRC cis rs7632954 0.605 rs6794255 chr3:8522820 G/C cg03495237 chr3:8533978 NA 0.36 6.58 0.34 1.9e-10 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs6570726 0.967 rs439017 chr6:145806123 T/C cg23711669 chr6:146136114 FBXO30 0.67 11.81 0.55 4.35e-27 Lobe attachment (rater-scored or self-reported); CRC cis rs10504229 0.815 rs72650879 chr8:58164648 A/G cg21724239 chr8:58056113 NA 0.65 8.48 0.42 7.95e-16 Developmental language disorder (linguistic errors); CRC cis rs950776 0.642 rs922691 chr15:78963994 A/G cg06917634 chr15:78832804 PSMA4 0.45 6.73 0.35 7.66e-11 Sudden cardiac arrest; CRC cis rs597539 0.690 rs552517 chr11:68625286 T/G cg06028808 chr11:68637592 NA 0.42 6.69 0.35 9.51e-11 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs2075371 1.000 rs2241335 chr7:133979368 C/T cg20476274 chr7:133979776 SLC35B4 0.81 14.65 0.63 9.37e-38 Mean platelet volume; CRC cis rs8062405 1.000 rs8055982 chr16:28881202 A/C cg08761264 chr16:28874980 SH2B1 -0.44 -5.82 -0.31 1.43e-8 Cognitive ability (multi-trait analysis);Cognitive ability; CRC cis rs919433 0.889 rs787998 chr2:198216092 A/G cg20885578 chr2:198174922 NA 0.34 5.61 0.3 4.32e-8 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC cis rs12368653 0.525 rs1564374 chr12:58010163 C/T cg12615879 chr12:58013172 SLC26A10 0.34 6.23 0.32 1.43e-9 Multiple sclerosis; CRC cis rs12594515 1.000 rs12595137 chr15:45986105 G/T cg06207120 chr15:45996521 NA 0.32 7.66 0.39 2.08e-13 Waist circumference;Weight; CRC cis rs2811415 0.597 rs12695505 chr3:127791636 G/A cg13719885 chr3:127795394 NA -0.4 -6.01 -0.31 5.05e-9 Lung function (FEV1/FVC); CRC cis rs116095464 0.558 rs62346508 chr5:203668 T/C cg22857025 chr5:266934 NA -1.12 -11.89 -0.55 2.32e-27 Breast cancer; CRC cis rs12913538 0.547 rs4573888 chr15:62896704 A/G cg09983546 chr15:62884068 NA 0.46 5.65 0.3 3.54e-8 Sleep depth; CRC cis rs73001065 0.711 rs58489806 chr19:19456917 C/T cg03709012 chr19:19516395 GATAD2A 0.75 5.85 0.31 1.2e-8 LDL cholesterol; CRC cis rs9916302 0.706 rs649180 chr17:37464959 A/C cg00129232 chr17:37814104 STARD3 0.57 6.78 0.35 5.6e-11 Glomerular filtration rate (creatinine); CRC cis rs11122272 0.637 rs2808593 chr1:231524228 G/T cg06096015 chr1:231504339 EGLN1 0.4 5.98 0.31 5.78e-9 Hemoglobin concentration; CRC cis rs7605827 0.866 rs6752546 chr2:15630729 T/C cg19274914 chr2:15703543 NA 0.39 5.95 0.31 6.89e-9 Educational attainment (years of education); CRC cis rs10782582 0.593 rs2147039 chr1:76143166 C/T cg10523679 chr1:76189770 ACADM -0.41 -5.79 -0.3 1.62e-8 Daytime sleep phenotypes; CRC cis rs2576037 0.899 rs2571034 chr18:44578565 A/G cg07416455 chr18:44543612 TCEB3CL;KATNAL2 0.51 7.49 0.38 6.26e-13 Personality dimensions; CRC cis rs9916302 0.904 rs620686 chr17:37453617 A/G cg03013999 chr17:37608204 MED1 -0.48 -7.51 -0.38 5.62e-13 Glomerular filtration rate (creatinine); CRC cis rs6502050 0.835 rs6502077 chr17:80122966 G/C cg02741985 chr17:80059408 CCDC57 0.43 7.15 0.37 5.59e-12 Life satisfaction; CRC cis rs17270561 0.609 rs4712964 chr6:25740822 A/T cg16482183 chr6:26056742 HIST1H1C 0.83 10.7 0.51 4.1000000000000003e-23 Iron status biomarkers; CRC cis rs2404602 0.583 rs3759853 chr15:76587777 C/T cg00316803 chr15:76480434 C15orf27 -0.41 -7.18 -0.37 4.82e-12 Blood metabolite levels; CRC cis rs12477438 0.520 rs34252185 chr2:99737646 A/G cg26064155 chr2:99771622 LIPT1;TSGA10 0.91 16.79 0.68 3.83e-46 Chronic sinus infection; CRC cis rs73200209 0.912 rs56381931 chr12:116491508 T/C cg01776926 chr12:116560359 MED13L -0.5 -6.16 -0.32 2.11e-9 Total body bone mineral density; CRC cis rs2882667 0.522 rs7731574 chr5:138454192 A/G cg09476006 chr5:138032270 NA -0.36 -6.07 -0.32 3.47e-9 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs4604732 0.631 rs10925044 chr1:247627071 A/G cg12758973 chr1:247694275 LOC148824;OR2C3 0.42 6.14 0.32 2.32e-9 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CRC cis rs13108904 0.846 rs4974574 chr4:1224811 A/G cg02018176 chr4:1364513 KIAA1530 0.4 6.63 0.34 1.37e-10 Obesity-related traits; CRC cis rs875971 0.929 rs778712 chr7:65849978 C/T cg18876405 chr7:65276391 NA 0.52 9.04 0.45 1.37e-17 Aortic root size; CRC cis rs7666738 0.830 rs10019087 chr4:99030211 C/T cg17366294 chr4:99064904 C4orf37 0.44 7.48 0.38 6.96e-13 Colonoscopy-negative controls vs population controls; CRC cis rs4819052 0.800 rs4819045 chr21:46660138 C/A cg19498844 chr21:46707878 POFUT2;LOC642852 0.77 10.99 0.52 3.97e-24 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC trans rs9467711 0.560 rs6900665 chr6:26487169 C/T cg06606381 chr12:133084897 FBRSL1 -0.77 -6.14 -0.32 2.33e-9 Autism spectrum disorder or schizophrenia; CRC cis rs6032067 0.929 rs13043296 chr20:43805688 T/C cg10761708 chr20:43804764 PI3 0.51 5.89 0.31 9.53e-9 Blood protein levels; CRC cis rs9902453 1.000 rs7223786 chr17:28332107 T/C cg26525008 chr17:28256777 EFCAB5;SSH2 -0.59 -8.79 -0.44 8.24e-17 Coffee consumption (cups per day); CRC cis rs1832871 0.711 rs9459877 chr6:158692331 G/A cg07165851 chr6:158734300 TULP4 0.6 7.58 0.39 3.46e-13 Height; CRC cis rs919433 1.000 rs7422899 chr2:198163527 G/C cg03934865 chr2:198174659 NA -0.46 -7.27 -0.37 2.72e-12 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC cis rs6952808 0.542 rs10243920 chr7:1950385 G/A cg14004847 chr7:1930337 MAD1L1 -0.4 -5.92 -0.31 8.27e-9 Bipolar disorder and schizophrenia; CRC cis rs10504229 1.000 rs67188507 chr8:58187492 A/T cg01721255 chr8:58191610 C8orf71 0.49 6.17 0.32 2e-9 Developmental language disorder (linguistic errors); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg22449854 chr4:169909815 CBR4 0.41 6.62 0.34 1.43e-10 Liver disease severity in Alagille syndrome; CRC cis rs11098499 0.863 rs10013305 chr4:120450424 G/A cg24375607 chr4:120327624 NA 0.47 7.05 0.36 1.06e-11 Corneal astigmatism; CRC cis rs7904985 1.000 rs12777097 chr10:88115638 G/A cg07322936 chr10:88137208 NA -0.49 -6.5 -0.34 3.03e-10 Barrett's esophagus; CRC cis rs3733585 0.673 rs4235347 chr4:9951956 C/T cg11266682 chr4:10021025 SLC2A9 -0.47 -9.62 -0.47 1.76e-19 Cleft plate (environmental tobacco smoke interaction); CRC cis rs896854 0.818 rs13262110 chr8:95926890 C/T cg09323728 chr8:95962352 TP53INP1 -0.39 -6.18 -0.32 1.85e-9 Type 2 diabetes; CRC cis rs4481887 0.927 rs4345830 chr1:248474845 G/C cg13385794 chr1:248469461 NA 0.38 6.75 0.35 6.84e-11 Common traits (Other); CRC cis rs6502050 0.731 rs34796376 chr17:80116635 G/T cg09264619 chr17:80180166 NA -0.34 -5.71 -0.3 2.52e-8 Life satisfaction; CRC cis rs523522 0.926 rs10774555 chr12:120971978 G/A cg12219531 chr12:120966889 COQ5 0.69 9.25 0.45 2.82e-18 High light scatter reticulocyte count; CRC cis rs6424115 0.830 rs1105 chr1:24200800 T/C cg15997130 chr1:24165203 NA 0.73 10.74 0.51 2.79e-23 Immature fraction of reticulocytes; CRC cis rs733592 0.507 rs10747529 chr12:48473369 G/A cg24011408 chr12:48396354 COL2A1 -0.47 -6.95 -0.36 1.97e-11 Plateletcrit; CRC cis rs2991971 0.967 rs6661321 chr1:45954599 C/G cg24296786 chr1:45957014 TESK2 0.55 8.31 0.42 2.53e-15 High light scatter reticulocyte count; CRC cis rs12594515 1.000 rs8038320 chr15:45990267 G/C cg22117107 chr15:45993392 NA -0.44 -9.09 -0.45 9.56e-18 Waist circumference;Weight; CRC cis rs1448094 0.872 rs7975457 chr12:86410404 C/T cg02569458 chr12:86230093 RASSF9 0.39 6.61 0.34 1.58e-10 Major depressive disorder; CRC cis rs4654899 0.931 rs4654880 chr1:21186608 C/A cg02927042 chr1:21476669 EIF4G3 0.41 6.54 0.34 2.33e-10 Superior frontal gyrus grey matter volume; CRC cis rs4561483 0.801 rs154148 chr16:11956478 T/C cg08843971 chr16:11963173 GSPT1 -0.62 -9.74 -0.47 7.13e-20 Testicular germ cell tumor; CRC trans rs951252 0.504 rs11734405 chr4:146081096 C/T cg22954265 chr20:29520583 NA -0.43 -5.99 -0.31 5.46e-9 Hip circumference; CRC cis rs7615952 0.599 rs60847438 chr3:125746005 T/C cg18479299 chr3:125709523 NA -0.54 -6.28 -0.33 1.04e-9 Blood pressure (smoking interaction); CRC cis rs769267 0.930 rs4808203 chr19:19568659 A/G cg02546618 chr19:19431379 KIAA0892;SF4 0.5 6.67 0.34 1.11e-10 Tonsillectomy; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg19259146 chr1:26856420 RPS6KA1 0.46 6.6 0.34 1.66e-10 Response to antipsychotic treatment; CRC cis rs1729951 0.575 rs361248 chr3:136709066 G/A cg21827317 chr3:136751795 NA 0.35 5.63 0.3 3.91e-8 Neuroticism; CRC cis rs2971970 0.519 rs6955700 chr7:133633345 T/C cg03336402 chr7:133662267 EXOC4 0.63 9.63 0.47 1.65e-19 Intelligence (multi-trait analysis); CRC cis rs11958404 0.860 rs72818111 chr5:157438361 A/G cg05962755 chr5:157440814 NA 1.01 12.88 0.58 5.12e-31 IgG glycosylation; CRC cis rs2839186 0.596 rs4819217 chr21:47644092 G/T cg12516959 chr21:47718080 NA -0.35 -6.06 -0.32 3.82e-9 Testicular germ cell tumor; CRC cis rs72781680 1.000 rs72781680 chr2:24238928 C/T cg08917208 chr2:24149416 ATAD2B 0.99 9.54 0.47 3.31e-19 Lymphocyte counts; CRC cis rs12474201 0.928 rs13429704 chr2:46960329 G/T cg06386533 chr2:46925753 SOCS5 0.77 12.9 0.58 4.49e-31 Height; CRC cis rs4481887 0.893 rs6702113 chr1:248486151 T/C cg00666640 chr1:248458726 OR2T12 0.46 7.93 0.4 3.55e-14 Common traits (Other); CRC cis rs4900538 0.927 rs1190544 chr14:102903398 G/A cg18135206 chr14:102964638 TECPR2 -0.97 -18.54 -0.71 4.73e-53 Mean corpuscular volume;Mean corpuscular hemoglobin; CRC trans rs10504229 0.953 rs6991035 chr8:58183374 C/T cg04077850 chr5:125800366 GRAMD3 0.37 6.27 0.33 1.15e-9 Developmental language disorder (linguistic errors); CRC cis rs6952808 0.792 rs2056480 chr7:1954301 A/G cg14004847 chr7:1930337 MAD1L1 0.44 6.01 0.31 4.85e-9 Bipolar disorder and schizophrenia; CRC cis rs11148252 0.574 rs9536247 chr13:53279542 T/C cg00495681 chr13:53174319 NA 0.9 17.25 0.69 5.9e-48 Lewy body disease; CRC cis rs1267303 0.642 rs6670699 chr1:46997270 C/T cg08533674 chr1:46993347 NA -0.8 -10.3 -0.49 9.2e-22 Monobrow; CRC cis rs4481887 0.927 rs4517383 chr1:248426484 C/T cg13385794 chr1:248469461 NA 0.41 7.14 0.37 5.85e-12 Common traits (Other); CRC cis rs2346160 0.899 rs384974 chr6:167688418 C/T cg27333441 chr6:167680455 NA -0.39 -6.36 -0.33 6.59e-10 Parental extreme longevity (95 years and older); CRC trans rs2303319 0.504 rs62187611 chr2:162431946 A/G cg12500891 chr11:57225987 NA -0.67 -5.98 -0.31 5.67e-9 Cognitive function; CRC cis rs2274273 0.905 rs10134800 chr14:55635209 A/G cg23234261 chr14:55582407 NA -0.3 -5.8 -0.3 1.59e-8 Protein biomarker; CRC cis rs2576037 0.763 rs2060418 chr18:44576535 A/C cg20875182 chr18:44561130 TCEB3B;KATNAL2 -0.48 -7.78 -0.39 9.26e-14 Personality dimensions; CRC cis rs7618915 0.547 rs11130315 chr3:52697163 A/G cg07507251 chr3:52567010 NT5DC2 0.42 6.06 0.32 3.7e-9 Bipolar disorder; CRC trans rs7824557 0.872 rs2572417 chr8:11111462 A/T cg06636001 chr8:8085503 FLJ10661 -0.47 -6.84 -0.35 3.98e-11 Retinal vascular caliber; CRC cis rs6088813 1.000 rs6088812 chr20:33974163 T/A cg14752227 chr20:34000481 UQCC -0.36 -5.62 -0.3 3.99e-8 Height; CRC cis rs9916302 0.706 rs2302073 chr17:37457342 A/G cg00129232 chr17:37814104 STARD3 0.57 7.22 0.37 3.66e-12 Glomerular filtration rate (creatinine); CRC trans rs9858542 1.000 rs9858542 chr3:49701983 A/G cg21659725 chr3:3221576 CRBN 0.66 8.76 0.43 1.08e-16 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs9443645 0.527 rs3902856 chr6:79699837 C/T cg09184832 chr6:79620586 NA -0.46 -7.8 -0.4 8.05e-14 Intelligence (multi-trait analysis); CRC cis rs56146971 0.763 rs12587463 chr14:91859967 C/T cg16433844 chr14:91963127 SMEK1 -0.59 -6.08 -0.32 3.27e-9 Alzheimer disease and age of onset; CRC cis rs2274273 1.000 rs7142704 chr14:55630603 C/A cg23234261 chr14:55582407 NA -0.29 -5.75 -0.3 2.01e-8 Protein biomarker; CRC cis rs9372498 0.536 rs9489436 chr6:118873817 A/C cg22561889 chr6:118971681 C6orf204 0.5 6.52 0.34 2.71e-10 Diastolic blood pressure; CRC cis rs45544231 0.569 rs12443621 chr16:52548037 A/G cg09051775 chr16:52580266 TOX3 -0.38 -6.16 -0.32 2.15e-9 Restless legs syndrome; CRC cis rs62103177 0.733 rs62096747 chr18:77619568 A/G cg12964065 chr18:77638022 KCNG2 0.62 6.64 0.34 1.3100000000000001e-10 Opioid sensitivity; CRC cis rs12543725 0.601 rs7018178 chr8:142239210 C/T cg17298326 chr8:142245477 NA 0.44 7.04 0.36 1.11e-11 Birth weight; CRC cis rs7264396 0.690 rs2425170 chr20:34442672 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.58 -9.59 -0.47 2.34e-19 Total cholesterol levels; CRC cis rs6424115 0.830 rs2501431 chr1:24201643 G/A cg15997130 chr1:24165203 NA 0.73 10.74 0.51 2.79e-23 Immature fraction of reticulocytes; CRC cis rs7666738 0.830 rs6818045 chr4:99049374 G/A cg17366294 chr4:99064904 C4orf37 0.45 7.75 0.39 1.16e-13 Colonoscopy-negative controls vs population controls; CRC cis rs2795502 1.000 rs1852959 chr10:43359636 T/C cg20628663 chr10:43360327 NA 0.71 11.01 0.52 3.19e-24 Blood protein levels; CRC cis rs2836633 1.000 rs2836631 chr21:40065906 G/T cg12884169 chr21:40033163 ERG -0.34 -7.5 -0.38 5.84e-13 Coronary artery disease; CRC cis rs2742417 1.000 rs2673038 chr3:45748632 A/G cg04837898 chr3:45731254 SACM1L -0.36 -5.92 -0.31 7.98e-9 Response to anti-depressant treatment in major depressive disorder; CRC cis rs4713118 0.513 rs183244 chr6:28031838 C/A cg10876282 chr6:28092338 ZSCAN16 0.49 6.5 0.34 2.92e-10 Parkinson's disease; CRC cis rs2404602 0.647 rs12903586 chr15:77168240 G/A cg23625390 chr15:77176239 SCAPER -0.88 -14.15 -0.62 7.73e-36 Blood metabolite levels; CRC trans rs561341 1.000 rs757009 chr17:30243937 A/G cg20587970 chr11:113659929 NA -0.97 -13.74 -0.6 2.78e-34 Hip circumference adjusted for BMI; CRC cis rs2404602 0.647 rs12440965 chr15:76958591 G/A cg03037974 chr15:76606532 NA -0.52 -7.7 -0.39 1.66e-13 Blood metabolite levels; CRC cis rs2739330 0.627 rs9608219 chr22:24274119 G/C cg10150615 chr22:24372951 LOC391322 -0.58 -8.62 -0.43 2.76e-16 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs60843830 1.000 rs17713396 chr2:227201 C/T cg00108164 chr2:264199 ACP1;SH3YL1 0.64 10.15 0.49 3.14e-21 Spherical equivalent (joint analysis main effects and education interaction); CRC cis rs10504229 0.728 rs1495867 chr8:58155500 G/T cg05313129 chr8:58192883 C8orf71 -0.47 -6.18 -0.32 1.94e-9 Developmental language disorder (linguistic errors); CRC cis rs6952808 0.564 rs55865401 chr7:2145720 G/C cg00106254 chr7:1943704 MAD1L1 -0.39 -5.64 -0.3 3.61e-8 Bipolar disorder and schizophrenia; CRC cis rs1801251 0.778 rs2592115 chr2:233736349 C/T cg25237894 chr2:233734115 C2orf82 -0.62 -10.79 -0.51 1.86e-23 Coronary artery disease; CRC cis rs947211 1.000 rs823144 chr1:205744546 C/A cg07157834 chr1:205819609 PM20D1 0.43 5.97 0.31 6.2e-9 Parkinson's disease; CRC cis rs11122272 0.766 rs2808608 chr1:231543175 A/G cg06096015 chr1:231504339 EGLN1 0.38 5.63 0.3 3.81e-8 Hemoglobin concentration; CRC cis rs10504229 0.815 rs16921955 chr8:58164553 C/T cg02725872 chr8:58115012 NA -0.47 -8.54 -0.43 5e-16 Developmental language disorder (linguistic errors); CRC trans rs6426142 0.790 rs2050626 chr1:224824294 A/G cg11504805 chr13:114815119 RASA3 -0.51 -5.96 -0.31 6.36e-9 Cancer; CRC cis rs7953508 0.750 rs7977788 chr12:93982332 G/A cg18151635 chr12:93972918 NA -0.59 -8.5 -0.42 6.66e-16 Pubertal anthropometrics; CRC cis rs875971 0.838 rs2173570 chr7:65762963 T/A cg18876405 chr7:65276391 NA -0.51 -8.6 -0.43 3.34e-16 Aortic root size; CRC cis rs1008375 0.864 rs4698196 chr4:17574735 T/C cg16339924 chr4:17578868 LAP3 0.66 8.27 0.42 3.25e-15 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs9381040 0.610 rs717883 chr6:41045270 T/C cg04346459 chr6:41068666 NFYA;LOC221442 -0.4 -5.82 -0.31 1.43e-8 Alzheimer's disease (late onset); CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg05366401 chr14:24664722 TM9SF1 0.44 5.96 0.31 6.41e-9 Anxiety disorder; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg23934081 chr20:32951001 ITCH 0.43 6.01 0.31 4.99e-9 Anxiety disorder; CRC trans rs61931739 0.679 rs10844831 chr12:34311245 G/T cg26384229 chr12:38710491 ALG10B 0.43 6.06 0.32 3.81e-9 Morning vs. evening chronotype; CRC cis rs7914558 0.966 rs943035 chr10:104839152 T/C cg04362960 chr10:104952993 NT5C2 0.59 8.82 0.44 6.6e-17 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs2153535 0.563 rs1796688 chr6:8536423 A/T cg07606381 chr6:8435919 SLC35B3 0.68 11.03 0.52 2.82e-24 Motion sickness; CRC trans rs72956618 1.000 rs68160031 chr2:207489365 T/G cg07171111 chr4:10462903 NA -0.71 -6.12 -0.32 2.7e-9 Tonsillectomy; CRC cis rs1215050 0.791 rs968854 chr4:98837863 T/C cg05340658 chr4:99064831 C4orf37 0.47 7.01 0.36 1.32e-11 Waist-to-hip ratio adjusted for body mass index; CRC cis rs7772486 0.558 rs2142978 chr6:146012061 T/C cg05347473 chr6:146136440 FBXO30 -0.49 -6.95 -0.36 1.98e-11 Lobe attachment (rater-scored or self-reported); CRC cis rs2573652 1.000 rs2727199 chr15:100514417 C/T cg00587665 chr15:100533223 ADAMTS17 -0.4 -6.84 -0.35 3.91e-11 Height; CRC trans rs6952808 0.608 rs58120505 chr7:2029867 T/C cg04565464 chr8:145669602 NFKBIL2 0.45 6.74 0.35 7.18e-11 Bipolar disorder and schizophrenia; CRC cis rs4604732 0.631 rs11490200 chr1:247625915 G/T cg12758973 chr1:247694275 LOC148824;OR2C3 0.42 6.14 0.32 2.32e-9 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CRC cis rs2361718 1.000 rs2361718 chr17:78103466 C/T cg20811857 chr17:78079795 GAA -0.35 -5.87 -0.31 1.06e-8 Yeast infection; CRC cis rs13108904 0.935 rs1732100 chr4:1281761 C/T cg20092199 chr4:1342459 KIAA1530 -0.38 -6.89 -0.36 2.8e-11 Obesity-related traits; CRC cis rs2832191 0.740 rs2853830 chr21:30416824 A/G cg08807101 chr21:30365312 RNF160 0.71 11.45 0.53 9.17e-26 Dental caries; CRC cis rs4665809 1.000 rs12471809 chr2:26307140 A/G cg04944784 chr2:26401820 FAM59B -0.6 -7.61 -0.39 2.93e-13 Gut microbiome composition (summer); CRC cis rs4862750 0.872 rs7671914 chr4:187878165 A/G cg22105103 chr4:187893119 NA 0.65 11.94 0.55 1.5e-27 Lobe attachment (rater-scored or self-reported); CRC cis rs7264396 0.635 rs6058351 chr20:34486093 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.56 -9.54 -0.47 3.28e-19 Total cholesterol levels; CRC cis rs1008375 0.931 rs6837181 chr4:17701253 A/C cg16339924 chr4:17578868 LAP3 0.48 6.21 0.32 1.63e-9 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs17067123 0.614 rs72712853 chr4:180066431 A/G cg26610307 chr4:180072759 NA -0.56 -6.74 -0.35 7.28e-11 Response to hepatitis C treatment; CRC cis rs11212617 0.967 rs227041 chr11:108222801 G/T cg01991180 chr11:108092276 ATM;NPAT 0.4 5.9 0.31 8.92e-9 Response to metformin in type 2 diabetes (glycemic); CRC cis rs9467773 1.000 rs767471 chr6:26557854 C/T cg09904177 chr6:26538194 HMGN4 0.85 14.85 0.63 1.61e-38 Intelligence (multi-trait analysis); CRC cis rs11025559 0.812 rs10766678 chr11:20507180 A/G cg19653624 chr11:20408972 PRMT3 -0.66 -8.0 -0.4 2.1e-14 Pursuit maintenance gain; CRC cis rs2204008 0.677 rs1581356 chr12:38391467 T/C cg26384229 chr12:38710491 ALG10B 0.67 9.43 0.46 7.4e-19 Bladder cancer; CRC cis rs13256369 1.000 rs10098234 chr8:8576692 G/A cg00074818 chr8:8560427 CLDN23 0.38 6.83 0.35 4.08e-11 Obesity-related traits; CRC cis rs5769765 0.730 rs62233964 chr22:50317410 C/G cg22709217 chr22:50311962 ALG12;CRELD2 -1.04 -14.94 -0.64 7.01e-39 Schizophrenia; CRC trans rs629535 0.911 rs627382 chr8:70014081 C/T cg21567404 chr3:27674614 NA -0.93 -15.92 -0.66 9.98e-43 Dupuytren's disease; CRC cis rs736408 0.716 rs2239550 chr3:52822509 G/C cg10802521 chr3:52805072 NEK4 -0.55 -8.08 -0.41 1.25e-14 Bipolar disorder; CRC trans rs55675132 0.548 rs12138998 chr1:115377168 A/G cg25493687 chr8:27288214 PTK2B 0.49 6.0 0.31 5.23e-9 Schizophrenia; CRC cis rs9649465 1.000 rs2299985 chr7:123369044 T/C cg03229431 chr7:123269106 ASB15 -0.36 -5.61 -0.3 4.22e-8 Migraine; CRC cis rs877282 0.838 rs11253373 chr10:774857 A/G cg06581033 chr10:766294 NA -0.49 -5.6 -0.3 4.41e-8 Uric acid levels; CRC cis rs7772486 0.686 rs9485019 chr6:146046381 C/G cg13319975 chr6:146136371 FBXO30 0.43 6.4 0.33 5.38e-10 Lobe attachment (rater-scored or self-reported); CRC cis rs7909074 1.000 rs4948927 chr10:45397071 G/A cg05187965 chr10:45406764 TMEM72 -0.36 -8.28 -0.42 3.21e-15 Mean corpuscular volume; CRC cis rs9311474 0.508 rs11718420 chr3:52611413 T/C cg18099408 chr3:52552593 STAB1 -0.48 -8.3 -0.42 2.81e-15 Electroencephalogram traits; CRC cis rs6860806 0.531 rs272888 chr5:131665423 T/C cg12564285 chr5:131593104 PDLIM4 0.44 7.37 0.38 1.38e-12 Breast cancer; CRC cis rs67311347 1.000 rs4128740 chr3:40519532 C/A cg09455208 chr3:40491958 NA 0.5 9.96 0.48 1.31e-20 Renal cell carcinoma; CRC cis rs10206020 0.759 rs11903889 chr2:1576601 C/T cg26248373 chr2:1572462 NA -0.83 -12.33 -0.56 5.69e-29 IgG glycosylation; CRC cis rs720844 0.748 rs35168772 chr2:149351228 A/G cg09247360 chr2:149335327 NA -0.62 -6.68 -0.35 9.92e-11 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs1448094 0.511 rs7968059 chr12:86163606 A/G cg25456477 chr12:86230367 RASSF9 0.38 6.48 0.34 3.29e-10 Major depressive disorder; CRC cis rs4728142 0.738 rs3807306 chr7:128580680 A/C cg14349538 chr7:128577651 IRF5 0.35 5.77 0.3 1.79e-8 Inflammatory bowel disease;Systemic lupus erythematosus;Ulcerative colitis; CRC cis rs7927771 0.864 rs755553 chr11:47432303 G/A cg20135002 chr11:47629003 NA 0.35 5.73 0.3 2.29e-8 Subjective well-being; CRC cis rs2836974 0.568 rs2142111 chr21:40549289 G/C cg17971929 chr21:40555470 PSMG1 0.69 10.34 0.5 7.09e-22 Cognitive function; CRC trans rs561341 0.941 rs2428338 chr17:30299629 T/C cg20587970 chr11:113659929 NA -1.16 -16.9 -0.68 1.4e-46 Hip circumference adjusted for BMI; CRC cis rs7626444 0.625 rs1798636 chr3:196476604 G/A cg12930392 chr3:196481615 PAK2 0.4 7.26 0.37 2.73e-12 Monocyte count; CRC cis rs1395 0.744 rs62130709 chr2:27505782 C/T cg23587288 chr2:27483067 SLC30A3 -0.44 -6.54 -0.34 2.36e-10 Blood metabolite levels; CRC cis rs12230513 0.732 rs61956303 chr12:55818071 C/A cg19537932 chr12:55886519 OR6C68 -0.74 -9.46 -0.46 5.95e-19 Contrast sensitivity; CRC cis rs9322193 0.923 rs1984111 chr6:150152856 G/A cg13206674 chr6:150067644 NUP43 0.53 7.5 0.38 6.09e-13 Lung cancer; CRC cis rs35306767 0.714 rs17293608 chr10:1056252 C/T cg26597838 chr10:835615 NA 0.86 10.18 0.49 2.37e-21 Eosinophil percentage of granulocytes; CRC cis rs2976388 0.524 rs7012804 chr8:143844650 A/G cg04969067 chr8:143858791 LYNX1 0.62 10.96 0.52 5.09e-24 Urinary tract infection frequency; CRC cis rs853679 0.517 rs1947863 chr6:28099344 G/A cg02683197 chr6:28174875 NA 0.85 10.52 0.5 1.71e-22 Depression; CRC cis rs2019137 0.936 rs2305133 chr2:113956821 C/G cg21610815 chr2:113994035 PAX8;LOC654433;LOC440839 -0.45 -6.28 -0.33 1.07e-9 Lymphocyte counts; CRC cis rs10504229 0.683 rs10504225 chr8:58145121 A/T cg24829409 chr8:58192753 C8orf71 -0.54 -8.0 -0.4 2.13e-14 Developmental language disorder (linguistic errors); CRC cis rs2404602 0.684 rs62026898 chr15:76944371 C/A cg03037974 chr15:76606532 NA -0.52 -7.89 -0.4 4.47e-14 Blood metabolite levels; CRC cis rs990171 0.506 rs2041748 chr2:102756295 A/G cg22835712 chr2:102737379 NA 0.44 6.03 0.32 4.38e-9 Lymphocyte counts; CRC cis rs965469 1.000 rs6051747 chr20:3307945 T/C cg25506879 chr20:3388711 C20orf194 -0.38 -5.62 -0.3 4.13e-8 IFN-related cytopenia; CRC cis rs561341 0.609 rs7209493 chr17:30197323 A/G cg12193833 chr17:30244370 NA 0.45 5.97 0.31 6.01e-9 Hip circumference adjusted for BMI; CRC cis rs896854 0.738 rs509594 chr8:95967156 C/G cg23172400 chr8:95962367 TP53INP1 0.41 6.13 0.32 2.47e-9 Type 2 diabetes; CRC cis rs754466 0.914 rs12218917 chr10:79701479 C/T cg17075019 chr10:79541650 NA -0.73 -10.27 -0.49 1.17e-21 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs7177699 0.557 rs7164479 chr15:79123054 C/T cg15571903 chr15:79123663 NA 0.34 6.87 0.35 3.29e-11 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; CRC cis rs1784581 0.802 rs2156747 chr6:162430000 C/G cg17173639 chr6:162384350 PARK2 -0.67 -11.14 -0.52 1.13e-24 Itch intensity from mosquito bite; CRC cis rs10540 1.000 rs12794284 chr11:477623 C/T cg03576123 chr11:487126 PTDSS2 -1.01 -10.48 -0.5 2.32e-22 Body mass index; CRC cis rs7617773 0.817 rs11707606 chr3:48237087 A/C cg11946769 chr3:48343235 NME6 0.71 9.58 0.47 2.51e-19 Coronary artery disease; CRC cis rs12477438 1.000 rs73963398 chr2:99887025 T/C cg26064155 chr2:99771622 LIPT1;TSGA10 -0.79 -9.74 -0.47 7.09e-20 Chronic sinus infection; CRC cis rs1223397 1.000 rs1223403 chr6:13271812 G/A cg06879394 chr6:13274151 PHACTR1 0.56 6.74 0.35 7.03e-11 Blood pressure; CRC trans rs1814175 0.645 rs10839382 chr11:49823172 C/T cg11707556 chr5:10655725 ANKRD33B -0.51 -9.55 -0.47 3.09e-19 Height; CRC cis rs9325144 0.600 rs11183505 chr12:38759110 G/T cg13010199 chr12:38710504 ALG10B -0.4 -5.66 -0.3 3.35e-8 Morning vs. evening chronotype; CRC cis rs2032447 0.831 rs9467664 chr6:26021813 A/T cg03517284 chr6:25882590 NA -0.52 -7.06 -0.36 9.99e-12 Intelligence (multi-trait analysis); CRC cis rs6570726 0.738 rs6925594 chr6:145898454 T/C cg05347473 chr6:146136440 FBXO30 0.38 5.86 0.31 1.15e-8 Lobe attachment (rater-scored or self-reported); CRC cis rs2282802 0.685 rs6893253 chr5:139661279 T/C cg26211634 chr5:139558579 C5orf32 0.41 7.01 0.36 1.34e-11 Intelligence (multi-trait analysis); CRC trans rs1814175 0.935 rs10839317 chr11:49657228 A/C cg03929089 chr4:120376271 NA -0.93 -17.05 -0.68 3.89e-47 Height; CRC cis rs10189230 0.967 rs12613015 chr2:222356119 G/A cg14652038 chr2:222343519 EPHA4 0.52 10.03 0.48 7.81e-21 Urate levels in lean individuals; CRC trans rs3845702 0.736 rs72958863 chr2:180808144 C/T cg25411327 chr19:5210703 PTPRS -0.59 -6.04 -0.32 4.15e-9 Schizophrenia; CRC cis rs372883 0.600 rs2832295 chr21:30739843 C/T cg24692254 chr21:30365293 RNF160 0.64 9.8 0.48 4.68e-20 Pancreatic cancer; CRC cis rs3823572 0.525 rs6467514 chr7:133687618 G/T cg03336402 chr7:133662267 EXOC4 -0.63 -9.29 -0.46 2.23e-18 Intelligence (multi-trait analysis); CRC trans rs561341 1.000 rs501957 chr17:30314504 C/T cg20587970 chr11:113659929 NA -1.37 -19.1 -0.73 2.9e-55 Hip circumference adjusted for BMI; CRC cis rs11098499 0.775 rs10021601 chr4:120282563 G/A cg09307838 chr4:120376055 NA 0.68 10.69 0.51 4.44e-23 Corneal astigmatism; CRC cis rs7809950 0.862 rs12112877 chr7:106941324 T/C cg23024343 chr7:107201750 COG5 -0.55 -7.76 -0.39 1.05e-13 Coronary artery disease; CRC cis rs290268 0.874 rs290988 chr9:93562955 C/G cg02608019 chr9:93564028 SYK 0.46 7.24 0.37 3.27e-12 Platelet count; CRC cis rs11212617 0.967 rs1583598 chr11:108305989 G/A cg01991180 chr11:108092276 ATM;NPAT 0.41 5.93 0.31 7.71e-9 Response to metformin in type 2 diabetes (glycemic); CRC cis rs8180040 0.620 rs6767907 chr3:47162661 C/T cg10298567 chr3:47292165 KIF9 0.39 6.09 0.32 3.16e-9 Colorectal cancer; CRC cis rs9323205 1.000 rs7149022 chr14:51613980 A/C cg23942311 chr14:51606299 NA -0.58 -7.12 -0.37 6.79e-12 Cancer; CRC cis rs1218582 0.772 rs4845688 chr1:154884142 T/C cg24250549 chr1:154909240 PMVK 0.65 11.3 0.53 3.06e-25 Prostate cancer; CRC cis rs13108904 0.870 rs1564508 chr4:1244879 A/G cg20092199 chr4:1342459 KIAA1530 0.32 5.77 0.3 1.87e-8 Obesity-related traits; CRC cis rs34375054 0.526 rs34764657 chr12:125679639 A/G cg25124228 chr12:125621409 AACS -0.59 -8.33 -0.42 2.17e-15 Post bronchodilator FEV1/FVC ratio; CRC cis rs3018066 0.720 rs10025052 chr4:106961846 C/T cg01869342 chr4:106983673 TBCK 0.43 6.39 0.33 5.72e-10 Cancer; CRC cis rs7666738 0.791 rs1426674 chr4:98924247 C/A cg17366294 chr4:99064904 C4orf37 0.43 7.32 0.37 1.95e-12 Colonoscopy-negative controls vs population controls; CRC cis rs6496044 0.568 rs2880765 chr15:86056462 A/T cg17133734 chr15:86042851 AKAP13 -0.41 -6.65 -0.34 1.21e-10 Interstitial lung disease; CRC cis rs875971 0.545 rs67397473 chr7:65633305 A/G cg02869306 chr7:64672164 INTS4L1 -0.43 -6.4 -0.33 5.39e-10 Aortic root size; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg09352908 chr3:37017749 NA -0.39 -6.29 -0.33 9.85e-10 Liver disease severity in Alagille syndrome; CRC trans rs57221529 0.709 rs72706612 chr5:561198 C/T cg25482853 chr8:67687455 SGK3 1.25 15.65 0.65 1.15e-41 Lung disease severity in cystic fibrosis; CRC cis rs7618915 0.501 rs62253740 chr3:52684128 A/T cg15147215 chr3:52552868 STAB1 -0.63 -10.84 -0.51 1.29e-23 Bipolar disorder; CRC cis rs2549003 0.934 rs2549006 chr5:131827065 A/G cg02551604 chr5:131831745 NA 0.58 9.09 0.45 9.78e-18 Asthma (sex interaction); CRC cis rs7843479 1.000 rs13276082 chr8:21823184 A/G cg17168535 chr8:21777572 XPO7 0.54 8.73 0.43 1.35e-16 Mean corpuscular volume; CRC cis rs1707322 1.000 rs785506 chr1:46540652 C/T cg06784218 chr1:46089804 CCDC17 -0.54 -9.36 -0.46 1.25e-18 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs4665809 0.590 rs35727620 chr2:26458364 G/A cg04944784 chr2:26401820 FAM59B 0.83 10.74 0.51 2.96e-23 Gut microbiome composition (summer); CRC cis rs910316 0.763 rs175014 chr14:75456927 A/G cg11812906 chr14:75593930 NEK9 -0.59 -8.95 -0.44 2.61e-17 Height; CRC cis rs10256972 0.568 rs1133043 chr7:1133305 C/G cg09177884 chr7:1199841 ZFAND2A -0.41 -5.84 -0.31 1.25e-8 Longevity;Endometriosis; CRC cis rs4663866 1.000 rs13033501 chr2:239181860 G/A cg16914508 chr2:239161102 PER2 0.77 7.88 0.4 4.89e-14 Irritable bowel syndrome; CRC cis rs1046896 0.512 rs3785513 chr17:80886748 G/A cg19046167 chr17:80928561 B3GNTL1 0.47 6.92 0.36 2.38e-11 Glycated hemoglobin levels; CRC cis rs6860806 0.507 rs274572 chr5:131710917 T/G cg27615366 chr5:131592974 PDLIM4 -0.33 -5.73 -0.3 2.32e-8 Breast cancer; CRC cis rs7264396 0.563 rs2425138 chr20:34345710 G/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.44 -6.2 -0.32 1.68e-9 Total cholesterol levels; CRC cis rs1552244 0.626 rs2886396 chr3:10037670 C/T cg16606324 chr3:10149918 C3orf24 0.62 8.08 0.41 1.25e-14 Alzheimer's disease; CRC cis rs2019137 0.560 rs7578633 chr2:113978650 C/T cg21610815 chr2:113994035 PAX8;LOC654433;LOC440839 0.6 8.69 0.43 1.73e-16 Lymphocyte counts; CRC cis rs7223966 1.000 rs7223966 chr17:61893398 G/A cg23090583 chr17:61904693 PSMC5;FTSJ3 0.53 6.48 0.34 3.26e-10 Hip circumference adjusted for BMI;Body mass index; CRC cis rs7959452 0.590 rs11177628 chr12:69765421 G/A cg22834771 chr12:69754056 YEATS4 -0.53 -8.03 -0.4 1.79e-14 Blood protein levels; CRC cis rs1552244 0.572 rs12107622 chr3:10171898 T/A cg18598329 chr3:10140678 FANCD2;C3orf24 -0.91 -10.7 -0.51 3.85e-23 Alzheimer's disease; CRC cis rs4660261 0.526 rs810680 chr1:44347856 C/T cg12908607 chr1:44402522 ARTN -0.52 -9.49 -0.46 4.8e-19 Intelligence (multi-trait analysis); CRC cis rs12620999 0.941 rs4663240 chr2:238036632 G/T cg23555395 chr2:238036564 NA -0.63 -9.93 -0.48 1.71e-20 Systemic lupus erythematosus; CRC cis rs763014 0.932 rs2384972 chr16:674424 G/A cg02475695 chr16:616220 NHLRC4 0.47 7.69 0.39 1.77e-13 Height; CRC cis rs3859192 0.599 rs2227319 chr17:38170845 G/A cg17467752 chr17:38218738 THRA -0.5 -7.2 -0.37 4.24e-12 White blood cell count; CRC cis rs7662987 0.517 rs2851268 chr4:100027878 A/G cg12011299 chr4:100065546 ADH4 0.49 9.27 0.46 2.46e-18 Smoking initiation; CRC cis rs908922 0.676 rs477621 chr1:152486252 T/C cg09873164 chr1:152488093 CRCT1 0.36 5.97 0.31 5.99e-9 Hair morphology; CRC cis rs7552404 0.924 rs67757078 chr1:76169456 G/A cg03433033 chr1:76189801 ACADM 0.92 14.06 0.61 1.66e-35 Blood metabolite levels;Acylcarnitine levels; CRC cis rs739401 0.611 rs2239900 chr11:3030992 C/T cg05729581 chr11:3078854 CARS -0.52 -7.61 -0.39 2.83e-13 Longevity; CRC trans rs61931739 0.517 rs12816252 chr12:34067693 G/A cg26384229 chr12:38710491 ALG10B 0.54 6.86 0.35 3.41e-11 Morning vs. evening chronotype; CRC cis rs7927592 0.913 rs3740631 chr11:68341722 T/G cg01657329 chr11:68192670 LRP5 -0.47 -6.79 -0.35 5.16e-11 Total body bone mineral density; CRC cis rs2153535 0.580 rs1414342 chr6:8462552 A/G cg21535247 chr6:8435926 SLC35B3 0.51 7.66 0.39 2.08e-13 Motion sickness; CRC cis rs10504229 0.683 rs6982990 chr8:58115275 C/T cg05313129 chr8:58192883 C8orf71 0.41 5.94 0.31 7.06e-9 Developmental language disorder (linguistic errors); CRC cis rs6502050 0.842 rs62079996 chr17:80076862 A/G cg25804541 chr17:80189381 SLC16A3 0.32 6.13 0.32 2.51e-9 Life satisfaction; CRC cis rs9837602 0.507 rs793448 chr3:99532949 G/C cg08350549 chr3:99591722 C3orf26;FILIP1L;MIR548G -0.38 -5.87 -0.31 1.05e-8 Breast cancer; CRC cis rs4975616 0.807 rs28379291 chr5:1313701 A/G cg26373071 chr5:1325741 CLPTM1L -0.41 -7.02 -0.36 1.3e-11 Lung cancer; CRC cis rs5769765 0.819 rs9616379 chr22:50312035 C/T cg04121214 chr22:50244548 NA 0.42 5.86 0.31 1.12e-8 Schizophrenia; CRC cis rs17209837 0.607 rs4148811 chr7:87101486 T/G cg00919237 chr7:87102261 ABCB4 -0.54 -7.1 -0.36 7.6e-12 Gallbladder cancer; CRC cis rs113835537 0.935 rs76228630 chr11:66458676 T/C cg22134325 chr11:66188745 NPAS4 0.38 6.39 0.33 5.81e-10 Airway imaging phenotypes; CRC trans rs11098499 0.774 rs73842616 chr4:120290683 G/A cg25214090 chr10:38739885 LOC399744 0.61 9.66 0.47 1.39e-19 Corneal astigmatism; CRC cis rs13108904 0.967 rs62293658 chr4:1276416 T/C cg21620606 chr4:1342894 KIAA1530 -0.42 -7.84 -0.4 6.21e-14 Obesity-related traits; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg04722249 chr2:97617061 FAM178B 0.42 6.44 0.33 4.22e-10 Intelligence (multi-trait analysis); CRC cis rs9733 0.519 rs7511673 chr1:150707636 A/T cg15448220 chr1:150897856 SETDB1 0.48 6.83 0.35 4.16e-11 Tonsillectomy; CRC cis rs3767633 0.925 rs4656335 chr1:161822078 A/G cg09175582 chr1:161736000 ATF6 0.7 6.29 0.33 9.96e-10 IgG glycosylation; CRC cis rs8060686 0.920 rs73594556 chr16:67925435 G/A cg04539111 chr16:67997858 SLC12A4 -0.48 -5.81 -0.31 1.47e-8 HDL cholesterol;Metabolic syndrome; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg26733140 chr11:63993641 NUDT22;TRPT1 -0.37 -6.44 -0.33 4.12e-10 Myopia (pathological); CRC cis rs12477438 0.520 rs11123764 chr2:99750677 T/C cg26064155 chr2:99771622 LIPT1;TSGA10 0.83 14.66 0.63 8.22e-38 Chronic sinus infection; CRC cis rs6499255 0.904 rs12447883 chr16:69722797 T/C cg05250797 chr16:70222502 NA 0.4 5.66 0.3 3.33e-8 IgE levels; CRC cis rs28386778 1.000 rs2665851 chr17:61957023 T/C cg11494091 chr17:61959527 GH2 0.62 10.68 0.51 4.83e-23 Prudent dietary pattern; CRC cis rs2576037 0.501 rs7227700 chr18:44537102 T/G cg19077165 chr18:44547161 KATNAL2 -0.57 -9.0 -0.44 1.86e-17 Personality dimensions; CRC cis rs9393777 0.513 rs7740197 chr6:26663478 C/T cg12292205 chr6:26970375 C6orf41 0.62 7.29 0.37 2.39e-12 Intelligence (multi-trait analysis); CRC cis rs9682041 0.696 rs13101192 chr3:170080752 C/G cg11886554 chr3:170076028 SKIL 0.73 8.53 0.43 5.5e-16 Glomerular filtration rate in non diabetics (creatinine);Glomerular filtration rate (creatinine); CRC cis rs6952808 0.601 rs3800882 chr7:2120758 G/A cg19897017 chr7:2163380 MAD1L1 0.46 6.83 0.35 4.17e-11 Bipolar disorder and schizophrenia; CRC cis rs11864453 0.826 rs2240243 chr16:72137561 A/G cg01557791 chr16:72042693 DHODH 0.46 6.46 0.34 3.81e-10 Fibrinogen levels; CRC cis rs728616 0.867 rs78131725 chr10:81820919 C/G cg11900509 chr10:81946545 ANXA11 -0.53 -5.67 -0.3 3.13e-8 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs17826219 0.561 rs4085382 chr17:29071202 T/C cg13385521 chr17:29058706 SUZ12P 0.6 7.41 0.38 1.1e-12 Body mass index; CRC cis rs4654899 0.758 rs9426652 chr1:21458151 G/A cg02927042 chr1:21476669 EIF4G3 -0.39 -6.24 -0.33 1.37e-9 Superior frontal gyrus grey matter volume; CRC trans rs7937682 0.889 rs10749984 chr11:111492861 T/C cg18187862 chr3:45730750 SACM1L 0.45 6.55 0.34 2.23e-10 Primary sclerosing cholangitis; CRC cis rs225245 0.817 rs225255 chr17:33955243 A/G cg05299278 chr17:33885742 SLFN14 -0.47 -7.6 -0.39 3.05e-13 Reticulocyte count;Reticulocyte fraction of red cells;High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells; CRC cis rs6901250 0.851 rs9374624 chr6:117145837 A/C cg12892004 chr6:117198278 RFX6 0.45 7.11 0.37 7.16e-12 C-reactive protein levels; CRC cis rs7666738 0.830 rs6846739 chr4:99016647 G/A cg05340658 chr4:99064831 C4orf37 0.61 9.48 0.46 5.18e-19 Colonoscopy-negative controls vs population controls; CRC cis rs3785574 0.962 rs8079161 chr17:61808561 C/G cg06873352 chr17:61820015 STRADA 0.5 7.97 0.4 2.7e-14 Height; CRC cis rs62064224 0.714 rs16967266 chr17:30632274 G/A cg18200150 chr17:30822561 MYO1D 0.47 9.4 0.46 9.88e-19 Schizophrenia; CRC cis rs7617773 0.780 rs36075665 chr3:48343087 C/T cg11946769 chr3:48343235 NME6 0.72 9.63 0.47 1.74e-19 Coronary artery disease; CRC cis rs4665809 1.000 rs7588802 chr2:26277789 A/G cg27170947 chr2:26402098 FAM59B -0.46 -6.1 -0.32 2.96e-9 Gut microbiome composition (summer); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg21219327 chr11:67980012 SUV420H1 0.42 6.56 0.34 2.11e-10 Response to antipsychotic treatment; CRC cis rs6921919 0.515 rs1558205 chr6:28382262 A/C cg21251018 chr6:28226885 NKAPL -0.42 -6.72 -0.35 8.23e-11 Autism spectrum disorder or schizophrenia; CRC cis rs6951245 0.572 rs11559183 chr7:1037025 C/A cg24642844 chr7:1081250 C7orf50 -0.9 -7.58 -0.39 3.51e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs10461617 0.541 rs832575 chr5:56161787 C/T cg12311346 chr5:56204834 C5orf35 -0.66 -6.98 -0.36 1.67e-11 Type 2 diabetes; CRC cis rs9611565 0.512 rs768414 chr22:42135751 T/C cg03806693 chr22:41940476 POLR3H 1.08 13.41 0.59 5.35e-33 Vitiligo; CRC cis rs1448094 0.817 rs7972773 chr12:86340774 A/C cg25456477 chr12:86230367 RASSF9 0.33 5.65 0.3 3.46e-8 Major depressive disorder; CRC cis rs4555082 0.874 rs2816606 chr14:105716034 C/T cg13114125 chr14:105738426 BRF1 -0.81 -11.88 -0.55 2.51e-27 Mean platelet volume;Platelet distribution width; CRC cis rs7943191 0.810 rs7942991 chr11:62337203 A/G cg22862634 chr11:62369728 EML3;MTA2 -0.52 -8.19 -0.41 5.75e-15 Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg20306694 chr12:51718251 BIN2 0.22 6.03 0.32 4.36e-9 Liver disease severity in Alagille syndrome; CRC cis rs1008375 0.931 rs6449310 chr4:17575530 T/C cg16339924 chr4:17578868 LAP3 0.59 7.87 0.4 5.15e-14 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs3820068 0.608 rs12092485 chr1:16048038 A/G cg24675056 chr1:15929824 NA 0.47 6.31 0.33 8.87e-10 Systolic blood pressure; CRC cis rs6502050 0.731 rs76421195 chr17:80109326 T/C cg09264619 chr17:80180166 NA -0.34 -5.81 -0.3 1.5e-8 Life satisfaction; CRC cis rs2075371 0.897 rs1646743 chr7:134003451 C/A cg02659138 chr7:134003124 SLC35B4 0.43 7.61 0.39 2.86e-13 Mean platelet volume; CRC cis rs1580019 0.961 rs1580021 chr7:32497702 T/G cg07520158 chr7:32535189 LSM5;AVL9 0.45 6.48 0.34 3.4e-10 Cognitive ability; CRC cis rs9560113 1.000 rs9555807 chr13:112179965 C/T cg14154082 chr13:112174009 NA 0.35 5.64 0.3 3.76e-8 Menarche (age at onset); CRC cis rs992157 0.835 rs10932769 chr2:219147245 T/G cg00012203 chr2:219082015 ARPC2 -0.47 -7.02 -0.36 1.25e-11 Colorectal cancer; CRC cis rs9467711 0.591 rs10484433 chr6:26030492 G/T cg08501292 chr6:25962987 TRIM38 0.83 7.28 0.37 2.46e-12 Autism spectrum disorder or schizophrenia; CRC trans rs208520 1.000 rs28773210 chr6:66993566 C/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.91 11.06 0.52 2.21e-24 Exhaled nitric oxide output; CRC cis rs4731207 0.698 rs10260710 chr7:124455986 C/A cg23710748 chr7:124431027 NA 0.38 6.08 0.32 3.42e-9 Cutaneous malignant melanoma; CRC cis rs875971 0.545 rs1796222 chr7:66057154 T/C cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.64 -8.24 -0.41 4.19e-15 Aortic root size; CRC cis rs2243480 1.000 rs1979823 chr7:65704613 G/A cg12463550 chr7:65579703 CRCP -0.68 -6.04 -0.32 4.07e-9 Diabetic kidney disease; CRC cis rs6546550 0.901 rs10496174 chr2:70153436 T/G cg02498382 chr2:70120550 SNRNP27 -0.54 -9.3 -0.46 2.07e-18 Prevalent atrial fibrillation; CRC cis rs10504229 0.635 rs72649130 chr8:58053810 G/T cg20607798 chr8:58055168 NA 0.55 6.19 0.32 1.82e-9 Developmental language disorder (linguistic errors); CRC cis rs1552244 0.572 rs59074548 chr3:10164347 G/C cg13047869 chr3:10149882 C3orf24 0.54 6.49 0.34 3.1e-10 Alzheimer's disease; CRC cis rs394563 0.619 rs4895787 chr6:149646500 G/A cg03678062 chr6:149772716 ZC3H12D 0.34 6.09 0.32 3.08e-9 Dupuytren's disease; CRC cis rs3751196 0.808 rs55949441 chr12:104217942 G/A cg02344784 chr12:104178138 NT5DC3 0.71 7.54 0.38 4.58e-13 Sense of smell; CRC cis rs763014 0.932 rs34498660 chr16:666149 A/G cg18653534 chr16:772142 FAM173A -0.37 -5.87 -0.31 1.08e-8 Height; CRC cis rs1008375 0.900 rs13144986 chr4:17675019 C/A cg16339924 chr4:17578868 LAP3 -0.54 -6.64 -0.34 1.3100000000000001e-10 Parasitemia in Tripanosoma cruzi seropositivity; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg13768304 chr14:94547498 DDX24;IFI27L1 0.47 6.12 0.32 2.73e-9 Thyroid stimulating hormone; CRC cis rs9039 1.000 rs67302637 chr16:9221100 C/T cg08831531 chr16:9218945 NA -0.55 -7.0 -0.36 1.48e-11 Menopause (age at onset); CRC cis rs11969893 0.850 rs9498418 chr6:101331838 A/T cg12253828 chr6:101329408 ASCC3 1.12 8.78 0.44 9.16e-17 Economic and political preferences (immigration/crime); CRC trans rs35785195 0.633 rs1035775 chr12:114230578 A/G cg16898576 chr11:63449499 RTN3 -0.48 -5.97 -0.31 6.21e-9 Daytime sleep phenotypes; CRC cis rs17376456 0.825 rs10476590 chr5:93244884 A/T cg09848695 chr5:92956644 FAM172A;MIR2277 0.66 5.83 0.31 1.32e-8 Diabetic retinopathy; CRC cis rs17253792 0.822 rs79807559 chr14:56108117 G/A cg01858014 chr14:56050164 KTN1 -0.87 -7.22 -0.37 3.59e-12 Putamen volume; CRC cis rs1008375 0.966 rs11733730 chr4:17625209 G/C cg02297831 chr4:17616191 MED28 0.47 6.3 0.33 9.62e-10 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs1707322 1.000 rs2458400 chr1:46530798 C/T cg06784218 chr1:46089804 CCDC17 -0.54 -9.36 -0.46 1.25e-18 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC trans rs66759488 0.739 rs10851451 chr15:47608991 A/G cg03629926 chr19:8438839 ANGPTL4 -0.44 -6.2 -0.32 1.67e-9 Lung cancer; CRC cis rs1150668 0.699 rs12214383 chr6:28223731 T/C cg06470822 chr6:28175283 NA -0.53 -7.95 -0.4 3.08e-14 Pubertal anthropometrics; CRC trans rs72766638 0.895 rs55924785 chr9:136929586 C/T cg09836344 chr4:1243392 C4orf42;CTBP1 -0.58 -6.29 -0.33 9.9e-10 Mosquito bite size; CRC cis rs6586163 1.000 rs1324551 chr10:90751516 C/T cg13456138 chr10:90753195 FAS -0.44 -6.82 -0.35 4.33e-11 Chronic lymphocytic leukemia; CRC cis rs7618501 0.521 rs11130222 chr3:49901060 A/T cg24110177 chr3:50126178 RBM5 -0.55 -7.89 -0.4 4.57e-14 Intelligence (multi-trait analysis); CRC cis rs55823223 0.648 rs936393 chr17:73847613 A/G cg08125733 chr17:73851984 WBP2 0.98 13.41 0.59 5.11e-33 Psoriasis; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg18675517 chr6:112364942 NA 0.46 6.31 0.33 9.15e-10 Anxiety disorder; CRC cis rs12545109 0.800 rs2670026 chr8:57424338 G/T cg09654669 chr8:57350985 NA -0.47 -7.51 -0.38 5.54e-13 Obesity-related traits; CRC cis rs6840360 0.642 rs6845648 chr4:152376050 C/T cg09659197 chr4:152720779 NA 0.33 6.46 0.34 3.69e-10 Intelligence (multi-trait analysis); CRC cis rs2576037 0.583 rs12386118 chr18:44540376 C/G cg23996704 chr18:44553084 KATNAL2 -0.4 -7.85 -0.4 6.07e-14 Personality dimensions; CRC trans rs877282 0.755 rs2790388 chr10:786084 T/C cg22713356 chr15:30763199 NA 1.0 12.25 0.56 1.08e-28 Uric acid levels; CRC cis rs3857536 0.813 rs62415859 chr6:66934278 G/A cg07460842 chr6:66804631 NA -0.42 -5.71 -0.3 2.5e-8 Blood trace element (Cu levels); CRC cis rs28386778 0.799 rs2727322 chr17:61921706 G/A cg22520471 chr17:61851767 DDX42;CCDC47 0.74 11.65 0.54 1.76e-26 Prudent dietary pattern; CRC cis rs12791968 0.917 rs11038239 chr11:45002012 A/G cg11846598 chr11:44996168 LOC221122 -0.72 -12.82 -0.58 8.7e-31 Inhibitory control; CRC cis rs7247513 0.759 rs8110545 chr19:12754898 C/T cg01871581 chr19:12707946 ZNF490 -0.76 -13.34 -0.59 9.58e-33 Bipolar disorder; CRC cis rs7614311 0.681 rs73117083 chr3:63948455 G/C cg22134162 chr3:63841271 THOC7 -0.57 -5.85 -0.31 1.16e-8 Lung function (FVC);Lung function (FEV1); CRC trans rs11098499 0.615 rs59867181 chr4:120556467 C/T cg25214090 chr10:38739885 LOC399744 -0.52 -8.18 -0.41 6.06e-15 Corneal astigmatism; CRC cis rs61861422 0.516 rs12412216 chr10:134393338 C/T cg20090690 chr10:134436459 INPP5A 0.56 6.39 0.33 5.74e-10 Primary sclerosing cholangitis; CRC cis rs1865760 0.516 rs9379819 chr6:26049819 A/C cg16482183 chr6:26056742 HIST1H1C 0.5 7.32 0.37 1.9e-12 Height; CRC cis rs7119 0.717 rs11631274 chr15:77816431 A/T cg27398640 chr15:77910606 LINGO1 -0.43 -7.47 -0.38 7.13e-13 Type 2 diabetes; CRC cis rs9488822 0.676 rs13210143 chr6:116389636 G/A cg15226275 chr6:116381976 FRK 0.29 8.24 0.41 4.19e-15 Cholesterol, total;LDL cholesterol; CRC cis rs7666738 0.830 rs10001702 chr4:99065160 T/G cg17366294 chr4:99064904 C4orf37 0.44 7.38 0.38 1.32e-12 Colonoscopy-negative controls vs population controls; CRC cis rs4742903 0.868 rs4743684 chr9:106852385 A/C cg21169611 chr9:106856078 SMC2 0.43 5.79 0.3 1.61e-8 High-grade serous ovarian cancer;Breast cancer; CRC cis rs8077889 1.000 rs2880329 chr17:41866168 T/A cg16892393 chr17:41919603 NA 0.56 7.83 0.4 6.58e-14 Triglycerides; CRC cis rs1555895 0.566 rs1000278 chr10:852629 C/T cg10556349 chr10:835070 NA -0.38 -7.48 -0.38 7.05e-13 Survival in rectal cancer; CRC cis rs11098499 0.908 rs12504149 chr4:120318577 G/A cg24375607 chr4:120327624 NA 0.5 7.67 0.39 1.93e-13 Corneal astigmatism; CRC cis rs1448094 0.512 rs7960130 chr12:86243191 T/C cg00310523 chr12:86230176 RASSF9 0.33 5.62 0.3 3.97e-8 Major depressive disorder; CRC trans rs561341 0.943 rs508566 chr17:30289861 G/C cg20587970 chr11:113659929 NA -1.42 -20.15 -0.74 2.3e-59 Hip circumference adjusted for BMI; CRC cis rs10078 0.571 rs2671890 chr5:456457 A/G cg08916839 chr5:415575 AHRR 0.83 8.44 0.42 1.04e-15 Fat distribution (HIV); CRC cis rs11098499 0.909 rs11098530 chr4:120413154 C/T cg09307838 chr4:120376055 NA 0.7 10.94 0.52 5.58e-24 Corneal astigmatism; CRC cis rs10752881 1.000 rs10911191 chr1:182984524 A/G ch.1.3577855R chr1:183094577 LAMC1 0.84 14.74 0.63 4.03e-38 Colorectal cancer; CRC cis rs9398803 0.865 rs9372840 chr6:126822635 A/C cg19875578 chr6:126661172 C6orf173 0.42 5.92 0.31 8.1e-9 Male-pattern baldness; CRC cis rs2046867 0.818 rs11928620 chr3:72863209 A/C cg25664220 chr3:72788482 NA -0.45 -6.31 -0.33 8.84e-10 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; CRC cis rs875971 0.545 rs12670811 chr7:65823019 C/A cg03233332 chr7:66118400 NA -0.43 -6.05 -0.32 3.99e-9 Aortic root size; CRC trans rs13182402 1.000 rs17154676 chr5:125912120 A/G cg14920044 chr10:91296311 SLC16A12 0.51 6.03 0.32 4.52e-9 Osteoporosis; CRC cis rs1799949 1.000 rs4534897 chr17:41431808 A/G cg05368731 chr17:41323189 NBR1 0.66 9.98 0.48 1.19e-20 Menopause (age at onset); CRC trans rs1499614 0.831 rs3800822 chr7:66147149 A/G cg10756647 chr7:56101905 PSPH -0.78 -8.17 -0.41 6.58e-15 Gout; CRC trans rs4785204 1.000 rs13339262 chr16:50091383 C/A cg07960154 chr17:37760198 NEUROD2 -0.67 -6.18 -0.32 1.87e-9 Esophageal cancer (squamous cell); CRC cis rs9788721 0.836 rs55983731 chr15:78735269 C/T cg18825076 chr15:78729989 IREB2 -0.46 -7.16 -0.37 5.14e-12 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio;Emphysema imaging phenotypes;Emphysema distribution in smoking;Local histogram emphysema pattern;Post bronchodilator FEV1/FVC ratio in COPD; CRC cis rs7113874 0.589 rs9705253 chr11:8596483 A/T cg02811074 chr11:8615871 STK33 -0.35 -6.02 -0.31 4.77e-9 Body mass index in physically active individuals;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs4819852 0.958 rs2238792 chr22:19983213 C/T cg07821417 chr22:19972146 ARVCF 0.47 6.34 0.33 7.76e-10 Pulse pressure; CRC cis rs4713118 0.869 rs9366700 chr6:27696951 C/T cg21251018 chr6:28226885 NKAPL 0.38 5.71 0.3 2.5e-8 Parkinson's disease; CRC cis rs6738485 0.601 rs7566680 chr2:106851657 G/A cg15412446 chr2:106886593 NA -0.39 -6.28 -0.33 1.08e-9 Pursuit maintenance gain;Pursuit maintenance gain in psychotic disorders; CRC cis rs826838 0.684 rs12367400 chr12:38618673 G/T cg13010199 chr12:38710504 ALG10B 0.45 5.74 0.3 2.17e-8 Heart rate; CRC cis rs911555 0.755 rs10148970 chr14:103892000 G/A cg12935359 chr14:103987150 CKB -0.57 -9.09 -0.45 9.6e-18 Intelligence (multi-trait analysis); CRC cis rs6831352 0.918 rs13107558 chr4:100050200 C/A cg12011299 chr4:100065546 ADH4 -0.45 -8.5 -0.42 6.89e-16 Alcohol dependence; CRC cis rs7666738 0.830 rs35644814 chr4:98886111 G/C cg05340658 chr4:99064831 C4orf37 0.56 8.41 0.42 1.28e-15 Colonoscopy-negative controls vs population controls; CRC trans rs916888 0.821 rs199525 chr17:44847834 T/G cg23590916 chr17:43697445 MGC57346 0.71 6.93 0.36 2.25e-11 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs13191362 0.935 rs35537826 chr6:163145867 G/A cg14584255 chr6:163149320 PACRG;PARK2 0.37 6.04 0.32 4.24e-9 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs9534288 0.797 rs4942467 chr13:46599817 A/C cg15192986 chr13:46630673 CPB2 -0.67 -9.81 -0.48 4.16e-20 Blood protein levels; CRC cis rs6502050 0.835 rs34199331 chr17:80134487 C/T cg25804541 chr17:80189381 SLC16A3 -0.31 -5.89 -0.31 9.39e-9 Life satisfaction; CRC cis rs2239547 0.657 rs4687672 chr3:52880543 G/A cg18404041 chr3:52824283 ITIH1 -0.4 -7.43 -0.38 9.42e-13 Schizophrenia; CRC cis rs17711722 0.701 rs781145 chr7:65440370 A/C cg02869306 chr7:64672164 INTS4L1 -0.35 -5.9 -0.31 8.98e-9 Calcium levels; CRC trans rs4824093 0.610 rs73441745 chr22:50237606 G/A cg09872104 chr7:134855509 C7orf49 -0.89 -7.22 -0.37 3.72e-12 Amyotrophic lateral sclerosis (sporadic); CRC cis rs2739330 0.627 rs9608219 chr22:24274119 G/C cg11060661 chr22:24314208 DDT;DDTL 0.51 8.87 0.44 4.67e-17 Liver enzyme levels (gamma-glutamyl transferase); CRC trans rs1814175 0.646 rs1722010 chr11:49897958 A/G cg03929089 chr4:120376271 NA -0.91 -15.83 -0.66 2.38e-42 Height; CRC cis rs17666538 0.585 rs4735812 chr8:607766 C/G cg02524346 chr8:600233 NA 0.92 8.52 0.43 5.87e-16 IgG glycosylation; CRC cis rs2204008 0.774 rs9669565 chr12:38294428 C/A cg13010199 chr12:38710504 ALG10B 0.46 6.25 0.33 1.25e-9 Bladder cancer; CRC cis rs35306767 0.668 rs12784928 chr10:1083617 A/C cg26597838 chr10:835615 NA 0.66 8.66 0.43 2.18e-16 Eosinophil percentage of granulocytes; CRC cis rs67478160 0.654 rs1997913 chr14:104213960 C/T cg01849466 chr14:104193079 ZFYVE21 -0.49 -8.76 -0.43 1.04e-16 Schizophrenia; CRC cis rs2239547 0.657 rs6445538 chr3:52874288 T/C cg18404041 chr3:52824283 ITIH1 -0.4 -7.43 -0.38 9.54e-13 Schizophrenia; CRC cis rs1401999 0.724 rs1016752 chr3:183665062 C/G cg05044414 chr3:183734942 ABCC5 -0.49 -7.86 -0.4 5.36e-14 Anterior chamber depth; CRC cis rs9837602 0.507 rs793453 chr3:99529095 A/C cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G -0.48 -6.43 -0.33 4.46e-10 Breast cancer; CRC cis rs11031096 0.542 rs6578424 chr11:3973140 G/A cg18678763 chr11:4115507 RRM1 -0.4 -6.8 -0.35 5.05e-11 Mean corpuscular volume;Mean corpuscular hemoglobin; CRC cis rs12477438 0.520 rs13030961 chr2:99799520 C/G cg26064155 chr2:99771622 LIPT1;TSGA10 0.86 15.72 0.65 6.2e-42 Chronic sinus infection; CRC cis rs4805272 0.539 rs17591634 chr19:29331628 A/C cg12756686 chr19:29218302 NA -0.51 -6.71 -0.35 8.57e-11 Plasma omega-3 polyunsaturated fatty acid levels (docosahexaenoic acid); CRC cis rs9291683 0.588 rs6844329 chr4:10018544 T/C cg00071950 chr4:10020882 SLC2A9 0.68 13.33 0.59 1.07e-32 Bone mineral density; CRC cis rs35146811 0.695 rs858508 chr7:99821381 C/G cg00553149 chr7:99775558 STAG3;GPC2 -0.25 -5.74 -0.3 2.16e-8 Coronary artery disease; CRC cis rs172166 0.694 rs536704 chr6:28092603 T/G cg15786705 chr6:28176104 NA 0.61 8.75 0.43 1.09e-16 Cardiac Troponin-T levels; CRC cis rs7659604 0.702 rs6826506 chr4:122710865 T/G cg19748678 chr4:122722346 EXOSC9 0.68 10.77 0.51 2.25e-23 Type 2 diabetes; CRC cis rs7739232 1.000 rs111278368 chr6:53530942 T/C cg15658676 chr6:53530538 KLHL31 -0.76 -5.9 -0.31 8.9e-9 Hip circumference adjusted for BMI; CRC cis rs6912958 0.559 rs242287 chr6:88071825 C/T cg12350822 chr6:88032061 C6orf162;GJB7 0.46 9.13 0.45 6.85e-18 Monocyte percentage of white cells; CRC cis rs34779708 0.931 rs7908573 chr10:35309513 T/C cg03585969 chr10:35415529 CREM 0.65 8.64 0.43 2.46e-16 Inflammatory bowel disease;Crohn's disease; CRC cis rs13191362 1.000 rs34714518 chr6:163080778 G/A cg06582575 chr6:163149167 PACRG;PARK2 0.93 11.84 0.55 3.47e-27 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg25518016 chr2:65092614 NA 0.44 6.17 0.32 2.01e-9 Response to antipsychotic treatment; CRC cis rs7937682 0.883 rs486038 chr11:111465963 A/C cg19812747 chr11:111475976 SIK2 -0.57 -9.72 -0.47 8.51e-20 Primary sclerosing cholangitis; CRC cis rs9322193 0.923 rs12174349 chr6:150039148 G/A cg13206674 chr6:150067644 NUP43 0.64 9.49 0.46 4.85e-19 Lung cancer; CRC cis rs8058578 1.000 rs56656810 chr16:30788759 C/A cg00531865 chr16:30841666 NA -0.46 -5.98 -0.31 5.85e-9 Multiple myeloma; CRC cis rs1348850 0.958 rs10930801 chr2:178459861 G/A cg02961200 chr2:178257176 LOC100130691;AGPS 0.49 6.94 0.36 2.03e-11 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs17253792 0.915 rs76957332 chr14:56195370 G/A cg01858014 chr14:56050164 KTN1 -0.77 -5.63 -0.3 3.85e-8 Putamen volume; CRC cis rs10504229 0.774 rs72650880 chr8:58164727 C/T cg02290350 chr8:58132656 NA -0.51 -6.01 -0.31 5.03e-9 Developmental language disorder (linguistic errors); CRC cis rs9768139 0.524 rs7779175 chr7:158136918 C/T cg23298862 chr7:158159286 PTPRN2 -0.59 -9.79 -0.47 4.97e-20 Calcium levels; CRC trans rs2303319 0.504 rs62189051 chr2:162622318 G/A cg27342122 chr8:133787442 PHF20L1 -0.72 -6.09 -0.32 3.2e-9 Cognitive function; CRC cis rs10504229 0.683 rs72650839 chr8:58130029 C/T cg05313129 chr8:58192883 C8orf71 -0.43 -6.11 -0.32 2.74e-9 Developmental language disorder (linguistic errors); CRC cis rs7927592 0.763 rs7129248 chr11:68263276 A/T cg16797656 chr11:68205561 LRP5 0.5 9.21 0.45 3.79e-18 Total body bone mineral density; CRC cis rs711245 0.572 rs3821150 chr2:36795233 G/A cg01206211 chr2:36825736 FEZ2 0.5 7.28 0.37 2.55e-12 Height; CRC cis rs7044106 0.718 rs1981021 chr9:123388393 T/G cg14255062 chr9:123606675 PSMD5;LOC253039 0.46 7.08 0.36 8.68e-12 Hip circumference adjusted for BMI; CRC cis rs4363385 0.818 rs2152994 chr1:152991060 C/T cg25856811 chr1:152973957 SPRR3 0.23 6.43 0.33 4.43e-10 Inflammatory skin disease; CRC cis rs6570726 0.791 rs387376 chr6:145822565 T/C cg23711669 chr6:146136114 FBXO30 0.74 12.97 0.58 2.27e-31 Lobe attachment (rater-scored or self-reported); CRC cis rs6424115 0.708 rs12755062 chr1:24185025 T/A cg10978503 chr1:24200527 CNR2 -0.43 -6.56 -0.34 2.09e-10 Immature fraction of reticulocytes; CRC cis rs911555 0.713 rs10162425 chr14:103931621 C/T cg12935359 chr14:103987150 CKB -0.54 -9.01 -0.44 1.74e-17 Intelligence (multi-trait analysis); CRC cis rs4555082 0.874 rs2816620 chr14:105732704 G/T cg13114125 chr14:105738426 BRF1 -0.84 -12.19 -0.56 1.82e-28 Mean platelet volume;Platelet distribution width; CRC cis rs2985684 0.748 rs2985686 chr14:50100683 C/G cg23565292 chr14:50234668 KLHDC2 -0.4 -5.77 -0.3 1.86e-8 Carotid intima media thickness; CRC cis rs4713118 0.516 rs4713142 chr6:28106347 T/G cg12273811 chr6:28175739 NA 0.73 9.36 0.46 1.34e-18 Parkinson's disease; CRC cis rs9814567 0.964 rs4539979 chr3:134287597 C/T cg06109529 chr3:134205091 CEP63;ANAPC13 -0.81 -12.14 -0.56 2.75e-28 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs2302190 0.882 rs3809709 chr17:56590559 C/T cg25885038 chr17:56607967 SEPT4 -0.52 -8.03 -0.4 1.7e-14 Vitamin D levels; CRC trans rs6550704 0.687 rs9865314 chr3:22634337 A/G cg01692572 chr8:144910787 PUF60 -0.43 -6.81 -0.35 4.55e-11 Daytime sleep phenotypes; CRC cis rs4555082 0.874 rs2245329 chr14:105719181 T/C cg18132624 chr14:105716052 BTBD6;BRF1 -0.48 -7.98 -0.4 2.46e-14 Mean platelet volume;Platelet distribution width; CRC cis rs3892630 0.824 rs2287882 chr19:33332952 C/T cg22980127 chr19:33182716 NUDT19 0.88 10.76 0.51 2.49e-23 Red blood cell traits; CRC cis rs7236492 0.515 rs76804350 chr18:77180607 C/T cg15644404 chr18:77186268 NFATC1 -0.81 -6.65 -0.34 1.23e-10 Inflammatory bowel disease;Crohn's disease; CRC cis rs796364 0.789 rs176008 chr2:200814720 A/T cg23649088 chr2:200775458 C2orf69 0.55 5.95 0.31 6.71e-9 Schizophrenia; CRC trans rs2243480 1.000 rs12698509 chr7:65418876 C/T cg10756647 chr7:56101905 PSPH 0.72 8.09 0.41 1.15e-14 Diabetic kidney disease; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg09765074 chr10:69634185 NA -0.41 -6.99 -0.36 1.55e-11 Liver disease severity in Alagille syndrome; CRC cis rs8180040 0.764 rs13062022 chr3:47169375 G/A cg10298567 chr3:47292165 KIF9 -0.36 -5.77 -0.3 1.86e-8 Colorectal cancer; CRC cis rs2932538 0.961 rs1238 chr1:113214097 G/A cg22162597 chr1:113214053 CAPZA1 -0.68 -9.67 -0.47 1.26e-19 Systolic blood pressure;Diastolic blood pressure;Hypertension;Blood pressure; CRC cis rs9311474 0.508 rs11714565 chr3:52606292 C/T cg08222913 chr3:52553049 STAB1 -0.34 -6.43 -0.33 4.5e-10 Electroencephalogram traits; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg06003594 chr17:21415244 NA -0.38 -6.07 -0.32 3.45e-9 Myopia (pathological); CRC cis rs10256972 0.567 rs7782651 chr7:1159895 T/G cg03188948 chr7:1209495 NA 0.48 6.79 0.35 5.13e-11 Longevity;Endometriosis; CRC cis rs7731657 0.537 rs72801772 chr5:130341294 G/T cg08523029 chr5:130500466 HINT1 -0.45 -5.79 -0.3 1.66e-8 Fasting plasma glucose; CRC cis rs2276314 0.532 rs11081927 chr18:33614282 C/T cg05985134 chr18:33552581 C18orf21 0.39 6.03 0.32 4.3e-9 Endometriosis;Drug-induced torsades de pointes; CRC cis rs9826463 0.582 rs11707154 chr3:142077131 A/T cg20824294 chr3:142316082 PLS1 0.35 5.92 0.31 8.15e-9 QRS duration in Tripanosoma cruzi seropositivity; CRC cis rs35110281 0.782 rs2246602 chr21:45064296 C/A cg01579765 chr21:45077557 HSF2BP -0.41 -8.09 -0.41 1.13e-14 Mean corpuscular volume; CRC cis rs8058578 0.943 rs3747486 chr16:30786927 C/T cg00531865 chr16:30841666 NA -0.48 -6.62 -0.34 1.42e-10 Multiple myeloma; CRC cis rs4665809 0.627 rs35461456 chr2:26482361 C/G cg04944784 chr2:26401820 FAM59B 0.85 11.05 0.52 2.29e-24 Gut microbiome composition (summer); CRC cis rs6933660 0.646 rs6911456 chr6:151778934 A/G cg14262678 chr6:151773367 RMND1;C6orf211 0.52 8.25 0.41 3.87e-15 Menarche (age at onset); CRC cis rs7113874 0.569 rs10769914 chr11:8576202 A/G cg17679104 chr11:8615758 STK33 -0.35 -5.9 -0.31 9.21e-9 Body mass index in physically active individuals;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs751728 0.664 rs4711347 chr6:33735292 G/A cg25922239 chr6:33757077 LEMD2 0.4 5.71 0.3 2.46e-8 Crohn's disease; CRC cis rs17767392 0.958 rs3784064 chr14:72059551 G/A cg13720639 chr14:72061746 SIPA1L1 0.56 7.06 0.36 1.02e-11 Mitral valve prolapse; CRC cis rs62432291 0.681 rs378547 chr6:159662525 A/G cg14500486 chr6:159655392 FNDC1 0.71 9.46 0.46 6.29e-19 Joint mobility (Beighton score); CRC cis rs4713118 0.669 rs200997 chr6:27811815 G/A cg26587870 chr6:27730563 NA -0.4 -6.22 -0.32 1.48e-9 Parkinson's disease; CRC cis rs6952808 0.723 rs4721264 chr7:2012997 G/A cg00106254 chr7:1943704 MAD1L1 -0.56 -8.11 -0.41 1.02e-14 Bipolar disorder and schizophrenia; CRC cis rs12580194 0.593 rs60230359 chr12:55736550 T/C cg23425280 chr12:56401806 NA 0.48 5.81 0.31 1.47e-8 Cancer; CRC cis rs10504229 1.000 rs9650139 chr8:58190508 G/T cg24829409 chr8:58192753 C8orf71 -0.68 -11.29 -0.53 3.23e-25 Developmental language disorder (linguistic errors); CRC cis rs6748734 1.000 rs4344931 chr2:241818527 A/C cg16358738 chr2:241808595 AGXT -0.39 -5.87 -0.31 1.07e-8 Urinary metabolites; CRC cis rs1045529 0.524 rs34251783 chr8:8891376 T/C cg06636001 chr8:8085503 FLJ10661 -0.47 -7.09 -0.36 7.99e-12 Myopia;Myopia (pathological); CRC trans rs1814175 0.817 rs11040651 chr11:49938395 G/A cg11707556 chr5:10655725 ANKRD33B -0.42 -7.98 -0.4 2.5e-14 Height; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg15214069 chr9:139333582 INPP5E 0.47 6.23 0.32 1.4e-9 Thyroid stimulating hormone; CRC cis rs936229 0.813 rs4886619 chr15:75106138 C/T cg14664628 chr15:75095509 CSK -1.03 -20.45 -0.75 1.51e-60 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); CRC cis rs7429990 0.965 rs4296617 chr3:48068308 T/C cg11946769 chr3:48343235 NME6 -0.5 -6.34 -0.33 7.42e-10 Educational attainment (years of education); CRC cis rs3858526 0.920 rs11039548 chr11:5930283 G/A cg13902645 chr11:5959945 NA -0.62 -8.67 -0.43 1.94e-16 DNA methylation (variation); CRC cis rs172166 0.561 rs149974 chr6:27985096 T/C cg23161317 chr6:28129485 ZNF389 0.38 5.67 0.3 3.16e-8 Cardiac Troponin-T levels; CRC cis rs7945718 0.875 rs9888258 chr11:12782716 A/G cg25843174 chr11:12811716 TEAD1 0.49 9.18 0.45 4.73e-18 Educational attainment (years of education); CRC cis rs12824058 0.831 rs4759658 chr12:130815872 C/T cg26677194 chr12:130822605 PIWIL1 0.45 7.42 0.38 9.93e-13 Menopause (age at onset); CRC cis rs11098499 0.954 rs6846442 chr4:120326323 G/A cg09307838 chr4:120376055 NA 0.72 11.14 0.52 1.1e-24 Corneal astigmatism; CRC cis rs9326248 0.520 rs6589602 chr11:117037065 T/C cg20608306 chr11:116969690 SIK3 0.31 6.27 0.33 1.13e-9 Blood protein levels; CRC cis rs7811142 1.000 rs6972167 chr7:100080013 G/T cg00814883 chr7:100076585 TSC22D4 -0.74 -9.36 -0.46 1.3e-18 Platelet count; CRC cis rs9611565 0.500 rs2011053 chr22:42121278 G/A cg03806693 chr22:41940476 POLR3H 0.67 9.45 0.46 6.78e-19 Vitiligo; CRC cis rs12594515 0.967 rs12595138 chr15:45986108 G/C cg19682013 chr15:45996608 NA 0.32 6.62 0.34 1.48e-10 Waist circumference;Weight; CRC cis rs72772090 0.539 rs13601 chr5:96110596 G/A cg17330273 chr5:96107758 CAST;ERAP1 -0.68 -6.02 -0.32 4.61e-9 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs9292777 0.777 rs1002922 chr5:40386555 T/C cg09067459 chr5:40385259 NA -0.56 -9.28 -0.46 2.31e-18 Crohn's disease;Multiple sclerosis; CRC cis rs9463078 0.770 rs9296453 chr6:45227432 C/T cg25276700 chr6:44698697 NA -0.27 -6.52 -0.34 2.58e-10 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg02955369 chr1:173837185 SNORD76;SNORD74;SNORD75;GAS5;ZBTB37 0.49 6.52 0.34 2.59e-10 Thyroid stimulating hormone; CRC cis rs7769051 1.000 rs9493444 chr6:133125320 C/G cg22852734 chr6:133119734 C6orf192 1.05 12.84 0.58 7.03e-31 Type 2 diabetes nephropathy; CRC cis rs10504229 0.775 rs56155911 chr8:58163247 C/T cg20607798 chr8:58055168 NA 0.47 5.79 0.3 1.67e-8 Developmental language disorder (linguistic errors); CRC cis rs4713118 0.869 rs7773070 chr6:27728827 T/C cg20933634 chr6:27740509 NA 0.57 8.28 0.42 3.08e-15 Parkinson's disease; CRC cis rs4711350 0.954 rs11751943 chr6:33729718 G/C cg07979401 chr6:33739406 LEMD2 -0.49 -5.82 -0.31 1.37e-8 Schizophrenia; CRC cis rs9938149 0.705 rs7405095 chr16:88307825 C/T cg05435882 chr16:88311214 NA 0.43 5.77 0.3 1.85e-8 Corneal structure;Central corneal thickness; CRC cis rs67311347 0.713 rs4974018 chr3:40307419 G/A cg09455208 chr3:40491958 NA 0.34 6.92 0.36 2.37e-11 Renal cell carcinoma; CRC cis rs2032447 0.714 rs199734 chr6:25940393 G/C cg03517284 chr6:25882590 NA -0.62 -8.64 -0.43 2.56e-16 Intelligence (multi-trait analysis); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg05051121 chr3:139062703 MRPS22 0.49 7.0 0.36 1.47e-11 Response to antipsychotic treatment; CRC cis rs4665809 1.000 rs7599132 chr2:26279810 A/T cg04944784 chr2:26401820 FAM59B 0.66 8.66 0.43 2.14e-16 Gut microbiome composition (summer); CRC cis rs6714710 0.603 rs7421146 chr2:98552271 G/C cg26665480 chr2:98280029 ACTR1B 0.56 7.64 0.39 2.41e-13 Posterior cortical atrophy and Alzheimer's disease; CRC cis rs12681287 0.640 rs13253515 chr8:87458596 T/A cg27223183 chr8:87520930 FAM82B -0.52 -7.44 -0.38 8.7e-13 Caudate activity during reward; CRC trans rs4650994 0.544 rs4132058 chr1:178505557 A/C cg27649806 chr9:35101217 STOML2 0.39 6.2 0.32 1.74e-9 HDL cholesterol levels;HDL cholesterol; CRC cis rs7666738 0.830 rs7672127 chr4:98938477 A/G cg17366294 chr4:99064904 C4orf37 0.43 7.34 0.38 1.65e-12 Colonoscopy-negative controls vs population controls; CRC cis rs972578 1.000 rs4822241 chr22:43369349 A/T cg01576275 chr22:43409880 NA -0.44 -6.92 -0.36 2.36e-11 Mean platelet volume; CRC cis rs7638909 0.512 rs6793245 chr3:38599037 A/G cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.51 7.37 0.38 1.43e-12 Electrocardiographic conduction measures; CRC cis rs2072510 0.593 rs2660892 chr12:96420978 T/C cg15438951 chr12:96389694 HAL -0.49 -5.82 -0.31 1.4e-8 Metabolite levels (small molecules and protein measures); CRC cis rs728616 0.867 rs61860412 chr10:81728486 G/A cg11900509 chr10:81946545 ANXA11 -0.66 -6.6 -0.34 1.67e-10 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs4594175 0.926 rs4901083 chr14:51604998 C/A cg23942311 chr14:51606299 NA 0.67 11.22 0.53 5.79e-25 Cancer; CRC cis rs6700896 0.966 rs12067936 chr1:66088701 C/A cg04111102 chr1:66153794 NA 0.33 5.96 0.31 6.62e-9 C-reactive protein;Mean corpuscular volume;Mean corpuscular hemoglobin; CRC cis rs245880 0.702 rs245884 chr7:29188475 T/G cg17163760 chr7:29186267 CPVL -0.39 -6.74 -0.35 7e-11 Warfarin maintenance dose; CRC trans rs1814175 0.935 rs11040463 chr11:49685574 C/T cg11707556 chr5:10655725 ANKRD33B -0.43 -7.93 -0.4 3.41e-14 Height; CRC cis rs28655083 0.529 rs285018 chr16:77099065 G/A cg01753188 chr16:77233325 SYCE1L;MON1B 0.46 6.45 0.33 4.06e-10 Lobe attachment (rater-scored or self-reported); CRC cis rs9372498 0.536 rs724868 chr6:118795152 C/T cg07617317 chr6:118971624 C6orf204 0.48 5.77 0.3 1.82e-8 Diastolic blood pressure; CRC trans rs7618501 0.602 rs2071207 chr3:50159844 T/C cg21665057 chr3:196295764 WDR53;FBXO45 -0.57 -9.14 -0.45 6.61e-18 Intelligence (multi-trait analysis); CRC cis rs853679 0.546 rs200977 chr6:27854301 T/C cg19041857 chr6:27730383 NA -0.76 -7.06 -0.36 1.01e-11 Depression; CRC cis rs17270561 0.609 rs1937132 chr6:25757017 A/G cg17691542 chr6:26056736 HIST1H1C 0.73 9.33 0.46 1.56e-18 Iron status biomarkers; CRC cis rs4268898 0.697 rs10445892 chr2:24406958 T/C cg26838691 chr2:24397539 C2orf84 0.41 5.76 0.3 1.93e-8 Asthma; CRC cis rs2404602 0.735 rs2461870 chr15:76813920 T/G cg03037974 chr15:76606532 NA -0.44 -6.82 -0.35 4.33e-11 Blood metabolite levels; CRC cis rs1448094 0.692 rs7958438 chr12:86326141 A/T cg18827107 chr12:86230957 RASSF9 -0.43 -6.89 -0.35 2.93e-11 Major depressive disorder; CRC cis rs6912958 0.684 rs2787893 chr6:88387359 C/G cg12350822 chr6:88032061 C6orf162;GJB7 -0.36 -6.73 -0.35 7.35e-11 Monocyte percentage of white cells; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg02760553 chr17:73975121 ACOX1;C17orf106 0.44 6.24 0.33 1.36e-9 Response to antipsychotic treatment; CRC cis rs7927592 0.731 rs11228288 chr11:68353550 A/G cg16797656 chr11:68205561 LRP5 0.49 8.95 0.44 2.7e-17 Total body bone mineral density; CRC cis rs12188164 0.620 rs56070387 chr5:482531 A/T cg26850624 chr5:429559 AHRR -0.72 -9.67 -0.47 1.27e-19 Cystic fibrosis severity; CRC cis rs1707322 1.000 rs10890365 chr1:46359348 C/T cg06784218 chr1:46089804 CCDC17 0.53 9.2 0.45 4.35e-18 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs10463316 0.744 rs6579869 chr5:150763621 G/A cg03212797 chr5:150827313 SLC36A1 -0.5 -7.78 -0.39 9.23e-14 Metabolite levels (Pyroglutamine); CRC cis rs3026101 0.671 rs2871203 chr17:5298490 T/C cg25236894 chr17:5323110 RPAIN;NUP88 0.42 6.84 0.35 3.98e-11 Body mass index; CRC cis rs1799949 0.602 rs4600503 chr17:41414324 C/G cg25072359 chr17:41440525 NA 0.45 6.86 0.35 3.32e-11 Menopause (age at onset); CRC trans rs3942852 1.000 rs3942852 chr11:48115089 C/T cg03929089 chr4:120376271 NA -0.51 -6.3 -0.33 9.75e-10 Acute lymphoblastic leukemia (childhood); CRC cis rs1348850 0.567 rs4893838 chr2:178531436 T/C cg02961200 chr2:178257176 LOC100130691;AGPS 0.51 7.07 0.36 9.06e-12 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs12477438 0.822 rs6727170 chr2:99588042 T/C cg26064155 chr2:99771622 LIPT1;TSGA10 -0.7 -8.72 -0.43 1.36e-16 Chronic sinus infection; CRC cis rs10504229 1.000 rs17216648 chr8:58169429 C/T cg24829409 chr8:58192753 C8orf71 -0.67 -11.22 -0.53 5.96e-25 Developmental language disorder (linguistic errors); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg22650146 chr1:221915355 DUSP10 0.45 6.18 0.32 1.87e-9 Response to antipsychotic treatment; CRC cis rs9368481 0.743 rs9368480 chr6:26955750 A/C cg12292205 chr6:26970375 C6orf41 0.72 11.33 0.53 2.35e-25 Autism spectrum disorder or schizophrenia; CRC cis rs883565 0.528 rs6599271 chr3:38970730 A/G cg01426195 chr3:39028469 NA 0.38 6.4 0.33 5.37e-10 Handedness; CRC cis rs77633900 0.772 rs2469554 chr15:76642700 G/C cg21673338 chr15:77095150 SCAPER -0.72 -6.27 -0.33 1.14e-9 Non-glioblastoma glioma;Glioma; CRC trans rs12310956 0.532 rs10844719 chr12:33987714 A/G cg26384229 chr12:38710491 ALG10B 0.47 6.34 0.33 7.71e-10 Morning vs. evening chronotype; CRC cis rs898097 0.812 rs7406011 chr17:80829980 C/T cg16060761 chr17:80687452 NA 0.42 6.02 0.31 4.68e-9 Breast cancer; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg00367438 chr7:150780797 TMUB1 0.44 6.12 0.32 2.69e-9 Response to antipsychotic treatment; CRC cis rs9311676 0.632 rs56398717 chr3:58404355 G/A cg06643156 chr3:58380774 PXK 0.42 6.38 0.33 5.84e-10 Systemic lupus erythematosus; CRC cis rs10078 0.528 rs2434697 chr5:466811 T/C cg24955955 chr5:415729 AHRR 0.66 6.43 0.33 4.45e-10 Fat distribution (HIV); CRC cis rs4713118 0.662 rs9468278 chr6:28028482 C/T cg25164649 chr6:28176230 NA 0.65 8.58 0.43 3.87e-16 Parkinson's disease; CRC cis rs7584330 0.554 rs116656801 chr2:238431257 A/G cg14458575 chr2:238380390 NA 0.53 6.95 0.36 1.99e-11 Prostate cancer; CRC trans rs1814175 0.817 rs1851858 chr11:49855638 G/A cg11707556 chr5:10655725 ANKRD33B -0.43 -8.19 -0.41 5.67e-15 Height; CRC cis rs11167764 1.000 rs7722567 chr5:141483178 C/T cg23435118 chr5:141488016 NDFIP1 -0.45 -7.1 -0.36 7.76e-12 Crohn's disease; CRC cis rs9287719 0.967 rs6750891 chr2:10738563 T/C cg00105475 chr2:10696890 NA 0.45 7.3 0.37 2.19e-12 Prostate cancer; CRC cis rs270601 0.770 rs1007602 chr5:131602166 T/C cg18758796 chr5:131593413 PDLIM4 0.48 8.82 0.44 7.04e-17 Acylcarnitine levels; CRC cis rs7186908 0.793 rs7191623 chr16:72212044 G/A cg23815491 chr16:72088622 HP 0.51 6.12 0.32 2.62e-9 Liver enzyme levels (alkaline phosphatase); CRC cis rs6456156 0.774 rs1012656 chr6:167525303 G/C cg19688584 chr6:167529678 CCR6 -0.33 -5.96 -0.31 6.35e-9 Primary biliary cholangitis; CRC cis rs4073582 0.595 rs801737 chr11:65928193 T/C cg14036092 chr11:66035641 RAB1B 0.53 8.81 0.44 7.14e-17 Gout; CRC cis rs7020830 0.898 rs495863 chr9:37346955 T/C cg14294708 chr9:37120828 ZCCHC7 1.06 21.7 0.77 1.94e-65 Schizophrenia; CRC cis rs79349575 0.721 rs4794004 chr17:47038471 C/T cg00947319 chr17:47005597 UBE2Z -0.33 -5.7 -0.3 2.61e-8 Type 2 diabetes; CRC cis rs1552244 0.510 rs13075308 chr3:10034925 G/C cg08888203 chr3:10149979 C3orf24 0.62 8.3 0.42 2.65e-15 Alzheimer's disease; CRC cis rs7666738 0.830 rs1593570 chr4:99017058 T/C cg05340658 chr4:99064831 C4orf37 0.61 9.48 0.46 5.18e-19 Colonoscopy-negative controls vs population controls; CRC cis rs995000 0.839 rs1168034 chr1:62963914 G/C cg19896129 chr1:63156450 NA -0.39 -5.96 -0.31 6.39e-9 Triglyceride levels; CRC trans rs11098499 0.648 rs2002047 chr4:120257228 A/G cg25214090 chr10:38739885 LOC399744 0.54 8.52 0.43 5.9e-16 Corneal astigmatism; CRC trans rs561341 0.830 rs7218801 chr17:30217778 A/G cg20587970 chr11:113659929 NA 0.9 11.07 0.52 1.93e-24 Hip circumference adjusted for BMI; CRC cis rs6694672 0.850 rs4915156 chr1:197062820 A/T cg13682187 chr1:196946512 CFHR5 0.55 8.27 0.42 3.27e-15 Asthma; CRC cis rs2991971 0.810 rs6657237 chr1:45920108 A/T cg24296786 chr1:45957014 TESK2 -0.47 -6.84 -0.35 3.92e-11 High light scatter reticulocyte count; CRC cis rs13191362 0.935 rs34934114 chr6:163082480 G/A cg06582575 chr6:163149167 PACRG;PARK2 0.93 11.84 0.55 3.47e-27 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs2248020 0.501 rs2263368 chr11:93264680 A/C cg15737290 chr11:93063684 CCDC67 0.45 7.29 0.37 2.37e-12 Insulin levels in response to oral glucose tolerance test (30 minutes); CRC cis rs10504229 0.683 rs11786074 chr8:58133532 A/G cg22535103 chr8:58192502 C8orf71 -0.7 -9.34 -0.46 1.47e-18 Developmental language disorder (linguistic errors); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg10164272 chr16:89456328 ANKRD11 -0.42 -7.01 -0.36 1.37e-11 Liver disease severity in Alagille syndrome; CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg17602823 chr1:28586543 SESN2 0.39 6.35 0.33 6.98e-10 Obesity-related traits; CRC cis rs7493 0.755 rs13228784 chr7:94960825 A/G cg21856205 chr7:94953877 PON1 -0.44 -5.8 -0.3 1.56e-8 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs4713118 0.869 rs6922574 chr6:27693003 A/T cg12172441 chr6:28176163 NA 0.53 7.09 0.36 8.34e-12 Parkinson's disease; CRC cis rs1218582 0.772 rs4240874 chr1:154885779 C/T cg24250549 chr1:154909240 PMVK 0.65 11.34 0.53 2.24e-25 Prostate cancer; CRC cis rs2933343 0.649 rs2638845 chr3:128587369 A/G cg11901034 chr3:128598214 ACAD9 -0.55 -8.07 -0.41 1.36e-14 IgG glycosylation; CRC cis rs6500602 0.893 rs4786490 chr16:4491190 C/T cg08645402 chr16:4508243 NA -0.52 -8.58 -0.43 3.88e-16 Schizophrenia; CRC cis rs7617773 0.817 rs3731497 chr3:48226553 T/G cg11946769 chr3:48343235 NME6 0.69 9.44 0.46 7.17e-19 Coronary artery disease; CRC cis rs274567 0.602 rs272853 chr5:131688561 A/G cg18301423 chr5:131593218 PDLIM4 0.36 6.18 0.32 1.93e-9 Blood metabolite levels; CRC cis rs763121 0.853 rs5757181 chr22:39013522 G/A cg06022373 chr22:39101656 GTPBP1 0.77 11.27 0.53 4.04e-25 Menopause (age at onset); CRC cis rs1475911 0.708 rs8129075 chr21:43523430 G/T cg24372256 chr21:43528868 UMODL1;C21orf128 -0.66 -10.09 -0.49 4.83e-21 IgG glycosylation; CRC cis rs2760061 0.583 rs708113 chr1:228192753 T/A cg02753203 chr1:228287806 NA 0.82 12.79 0.58 1.09e-30 Diastolic blood pressure; CRC cis rs6570726 0.905 rs430248 chr6:145874104 A/G cg05347473 chr6:146136440 FBXO30 0.39 6.19 0.32 1.84e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs793571 0.544 rs1427282 chr15:58914326 C/T cg05156742 chr15:59063176 FAM63B 0.44 6.96 0.36 1.9e-11 Schizophrenia; CRC cis rs796364 1.000 rs281774 chr2:200814572 C/T cg23649088 chr2:200775458 C2orf69 0.55 5.95 0.31 6.71e-9 Schizophrenia; CRC cis rs75920871 0.588 rs7118591 chr11:116908457 A/C cg20608306 chr11:116969690 SIK3 0.31 5.67 0.3 3.15e-8 Subjective well-being; CRC cis rs644799 0.544 rs498553 chr11:95534441 G/A cg25622487 chr11:95524042 FAM76B;CEP57 0.57 8.57 0.43 4.05e-16 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC trans rs360798 0.532 rs1553832 chr2:63013515 C/G cg05376469 chr2:102649931 NA 0.38 6.23 0.32 1.4e-9 Coronary artery disease; CRC cis rs17345786 1.000 rs3762729 chr3:101308874 C/T cg11279151 chr3:101281821 RG9MTD1 -0.7 -8.81 -0.44 7.18e-17 Colonoscopy-negative controls vs population controls; CRC cis rs8060686 0.545 rs12444188 chr16:68282077 G/A cg26727032 chr16:67993705 SLC12A4 -0.62 -6.52 -0.34 2.61e-10 HDL cholesterol;Metabolic syndrome; CRC trans rs459571 0.959 rs2073818 chr9:136918662 C/A cg15028160 chr19:49622717 PPFIA3;C19orf73 -0.55 -6.91 -0.36 2.59e-11 Platelet distribution width; CRC cis rs9311474 0.508 rs7614498 chr3:52618941 A/T cg11645453 chr3:52864694 ITIH4 0.35 6.37 0.33 6.5e-10 Electroencephalogram traits; CRC cis rs9814567 0.964 rs9815983 chr3:134222507 G/T cg06109529 chr3:134205091 CEP63;ANAPC13 -0.81 -12.26 -0.56 1e-28 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs2180341 1.000 rs6569486 chr6:127708424 A/C cg27446573 chr6:127587934 RNF146 0.99 13.91 0.61 6.24e-35 Breast cancer; CRC cis rs6674970 1.000 rs6674970 chr1:151116279 C/T cg03258749 chr1:151040405 MLLT11 -0.49 -7.58 -0.39 3.66e-13 Childhood ear infection; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg02809009 chr19:50354510 PTOV1 0.4 6.38 0.33 6.01e-10 Liver disease severity in Alagille syndrome; CRC cis rs870825 0.929 rs72689255 chr4:185590141 T/C cg04058563 chr4:185651563 MLF1IP 0.7 7.14 0.37 5.83e-12 Blood protein levels; CRC trans rs61931739 0.534 rs1490109 chr12:34064077 T/C cg26384229 chr12:38710491 ALG10B 0.52 7.08 0.36 8.63e-12 Morning vs. evening chronotype; CRC trans rs7937682 0.889 rs551825 chr11:111480116 C/G cg18187862 chr3:45730750 SACM1L 0.45 6.55 0.34 2.23e-10 Primary sclerosing cholangitis; CRC cis rs7659604 1.000 rs7659943 chr4:122665560 C/T cg06713675 chr4:122721982 EXOSC9 -0.4 -6.47 -0.34 3.63e-10 Type 2 diabetes; CRC trans rs10982213 0.830 rs2274163 chr9:117188714 C/T cg08833169 chr11:810149 RPLP2 0.37 6.01 0.31 4.98e-9 Interleukin-6 levels; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg27555392 chr1:16679092 FBXO42 0.36 6.01 0.31 4.84e-9 Liver disease severity in Alagille syndrome; CRC cis rs2576037 0.583 rs641366 chr18:44430326 C/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.61 10.87 0.51 1.04e-23 Personality dimensions; CRC cis rs6502050 0.835 rs3935129 chr17:80113381 G/C cg11859384 chr17:80120422 CCDC57 -0.37 -5.85 -0.31 1.16e-8 Life satisfaction; CRC cis rs1003719 0.788 rs1543750 chr21:38446918 A/G cg10648535 chr21:38446584 PIGP;TTC3 0.53 7.58 0.39 3.56e-13 Eye color traits; CRC cis rs9326248 1.000 rs4938354 chr11:117051165 A/G cg10398005 chr11:117014888 PAFAH1B2 -0.41 -5.98 -0.31 5.79e-9 Blood protein levels; CRC trans rs34421088 0.560 rs2248325 chr8:11396874 A/G cg06636001 chr8:8085503 FLJ10661 -0.52 -7.72 -0.39 1.4e-13 Neuroticism; CRC cis rs7107174 0.901 rs4944199 chr11:78122779 A/G cg02023728 chr11:77925099 USP35 0.38 6.05 0.32 4.05e-9 Testicular germ cell tumor; CRC cis rs7937682 0.855 rs11213985 chr11:111581521 C/A cg19812747 chr11:111475976 SIK2 -0.56 -9.46 -0.46 5.88e-19 Primary sclerosing cholangitis; CRC cis rs6424115 0.767 rs11591202 chr1:24102080 A/C cg10978503 chr1:24200527 CNR2 -0.42 -6.43 -0.33 4.43e-10 Immature fraction of reticulocytes; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg26352439 chr17:157043 RPH3AL 0.38 5.99 0.31 5.35e-9 Myopia (pathological); CRC cis rs1799949 1.000 rs4340367 chr17:41307772 G/A cg25072359 chr17:41440525 NA 0.46 6.96 0.36 1.91e-11 Menopause (age at onset); CRC cis rs12950390 0.776 rs4793646 chr17:45853966 A/C cg24803719 chr17:45855879 NA -0.32 -7.02 -0.36 1.24e-11 IgG glycosylation; CRC cis rs35995292 0.500 rs28369620 chr7:38921872 C/T cg19327137 chr7:38886074 VPS41 0.62 10.13 0.49 3.53e-21 Subjective well-being (multi-trait analysis); CRC cis rs7085104 0.572 rs284858 chr10:104573936 T/C cg11453585 chr10:104263688 ACTR1A;SUFU 0.39 5.6 0.3 4.51e-8 Immature fraction of reticulocytes;Schizophrenia; CRC cis rs9309711 0.643 rs10188449 chr2:3480366 T/C cg15506890 chr2:3487001 NA -0.54 -8.72 -0.43 1.4e-16 Neurofibrillary tangles; CRC cis rs9309711 0.961 rs11678655 chr2:3476234 T/G cg10845886 chr2:3471009 TTC15 -0.72 -11.6 -0.54 2.56e-26 Neurofibrillary tangles; CRC cis rs17023223 0.581 rs2765529 chr1:119581900 C/T cg05756136 chr1:119680316 WARS2 -0.47 -6.37 -0.33 6.39e-10 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for BMI in active individuals; CRC cis rs6500602 0.727 rs3761681 chr16:4566857 C/T cg14951292 chr16:4525986 HMOX2;NMRAL1 0.57 8.77 0.44 9.89e-17 Schizophrenia; CRC cis rs11123610 0.520 rs7576146 chr2:3718393 A/C cg19052272 chr2:3704530 ALLC -0.62 -7.69 -0.39 1.68e-13 Response to inhaled corticosteroid treatment in asthma (change in FEV1); CRC cis rs1865760 0.588 rs9467658 chr6:26010881 T/G cg17691542 chr6:26056736 HIST1H1C 0.57 8.82 0.44 6.74e-17 Height; CRC cis rs2692947 0.770 rs4527246 chr2:96560303 T/C cg22654517 chr2:96458247 NA 0.32 5.72 0.3 2.43e-8 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; CRC cis rs7772486 0.790 rs9390365 chr6:146235626 A/G cg13319975 chr6:146136371 FBXO30 0.43 6.52 0.34 2.65e-10 Lobe attachment (rater-scored or self-reported); CRC cis rs3087591 0.683 rs4368212 chr17:29639263 C/T cg24425628 chr17:29625626 OMG;NF1 0.74 13.4 0.59 5.43e-33 Hip circumference; CRC cis rs1448094 0.510 rs1993806 chr12:86147151 T/C cg25456477 chr12:86230367 RASSF9 -0.36 -6.07 -0.32 3.43e-9 Major depressive disorder; CRC cis rs9486715 1.000 rs9486715 chr6:97059769 A/C cg06623918 chr6:96969491 KIAA0776 -0.98 -17.96 -0.7 9.76e-51 Headache; CRC cis rs8064299 0.967 rs880827 chr17:72767435 C/T cg25054828 chr17:72772726 NAT9;TMEM104 -0.62 -9.99 -0.48 1.08e-20 Monocyte count; CRC trans rs926326 0.789 rs62392334 chr6:25506415 A/G cg25354657 chr11:129991445 APLP2 -0.43 -6.34 -0.33 7.39e-10 Platelet count; CRC cis rs4658101 0.667 rs4658235 chr1:92049788 G/A cg24006770 chr1:92056542 NA 0.45 6.52 0.34 2.61e-10 Optic disc area;Vertical cup-disc ratio; CRC cis rs853679 0.517 rs9380056 chr6:28104476 C/T cg12963246 chr6:28129442 ZNF389 0.49 5.78 0.3 1.73e-8 Depression; CRC trans rs931812 0.895 rs4734013 chr8:101908687 A/C cg20993868 chr7:22813445 NA 0.54 9.9 0.48 2.17e-20 Attention deficit hyperactivity disorder and conduct disorder; CRC cis rs941873 0.868 rs4980063 chr10:81105844 A/T cg09469691 chr10:81107165 PPIF 0.53 8.63 0.43 2.65e-16 Height; CRC cis rs3768617 0.510 rs10797843 chr1:183081995 A/G ch.1.3577855R chr1:183094577 LAMC1 0.88 15.5 0.65 4.51e-41 Fuchs's corneal dystrophy; CRC cis rs9322193 0.962 rs10214845 chr6:150104260 A/G cg13206674 chr6:150067644 NUP43 0.57 8.14 0.41 8.29e-15 Lung cancer; CRC cis rs8005677 1.000 rs7145494 chr14:23399790 T/C cg01529538 chr14:23388837 RBM23 0.39 6.13 0.32 2.52e-9 Cognitive ability (multi-trait analysis); CRC cis rs4665809 0.590 rs10179959 chr2:26426403 G/A cg04944784 chr2:26401820 FAM59B -0.84 -10.78 -0.51 2.06e-23 Gut microbiome composition (summer); CRC cis rs9467711 0.790 rs34158769 chr6:26336572 G/A cg16898833 chr6:26189333 HIST1H4D 1.05 7.92 0.4 3.77e-14 Autism spectrum disorder or schizophrenia; CRC cis rs62229266 0.659 rs2255734 chr21:37411909 T/C cg08632701 chr21:37451849 NA -0.4 -6.28 -0.33 1.08e-9 Mitral valve prolapse; CRC cis rs780096 0.565 rs10169261 chr2:27727314 C/T cg22903471 chr2:27725779 GCKR -0.38 -6.12 -0.32 2.7e-9 Total body bone mineral density; CRC cis rs2742417 1.000 rs2673047 chr3:45743113 A/G cg04837898 chr3:45731254 SACM1L -0.36 -5.92 -0.31 7.98e-9 Response to anti-depressant treatment in major depressive disorder; CRC cis rs12760731 0.641 rs12691479 chr1:178328754 G/A cg00404053 chr1:178313656 RASAL2 0.93 9.79 0.48 4.84e-20 Obesity-related traits; CRC cis rs2976388 0.609 rs2585152 chr8:143786214 A/T cg22687807 chr8:143858763 LYNX1 0.51 9.1 0.45 8.59e-18 Urinary tract infection frequency; CRC cis rs9467773 0.587 rs9467722 chr6:26352566 T/C cg14345882 chr6:26364793 BTN3A2 0.41 6.35 0.33 7.22e-10 Intelligence (multi-trait analysis); CRC cis rs4654899 0.865 rs61779073 chr1:21398740 C/A cg02927042 chr1:21476669 EIF4G3 -0.51 -7.76 -0.39 1.05e-13 Superior frontal gyrus grey matter volume; CRC cis rs17095355 0.688 rs1349348 chr10:111794554 T/C cg00817464 chr10:111662876 XPNPEP1 0.48 6.07 0.32 3.57e-9 Biliary atresia; CRC cis rs9292777 0.720 rs10071761 chr5:40415611 T/C cg09067459 chr5:40385259 NA -0.54 -8.96 -0.44 2.39e-17 Crohn's disease;Multiple sclerosis; CRC trans rs853679 1.000 rs11965538 chr6:28239915 G/A cg06606381 chr12:133084897 FBRSL1 -0.64 -6.29 -0.33 1.01e-9 Depression; CRC cis rs3751196 0.808 rs75536713 chr12:104210958 C/T cg02344784 chr12:104178138 NT5DC3 0.71 7.54 0.38 4.58e-13 Sense of smell; CRC cis rs7666738 0.830 rs11729753 chr4:98803267 T/A cg05340658 chr4:99064831 C4orf37 0.56 7.98 0.4 2.47e-14 Colonoscopy-negative controls vs population controls; CRC cis rs9303401 0.659 rs12602389 chr17:56779778 G/A cg02118635 chr17:56770003 RAD51C;TEX14 0.79 10.13 0.49 3.5e-21 Cognitive test performance; CRC cis rs2836974 0.584 rs7276774 chr21:40628725 T/G cg17971929 chr21:40555470 PSMG1 -0.73 -11.42 -0.53 1.14e-25 Cognitive function; CRC cis rs9525927 0.625 rs9533802 chr13:44820059 C/T cg19190762 chr13:44806055 NA 0.56 6.59 0.34 1.71e-10 Dupuytren's disease; CRC cis rs9443645 0.869 rs9361467 chr6:79621098 A/G cg11833968 chr6:79620685 NA -0.37 -6.4 -0.33 5.25e-10 Intelligence (multi-trait analysis); CRC cis rs514406 0.929 rs562178 chr1:53319562 T/C cg25767906 chr1:53392781 SCP2 -0.46 -7.59 -0.39 3.43e-13 Monocyte count; CRC cis rs1707322 0.963 rs4630155 chr1:46257110 G/C cg03146154 chr1:46216737 IPP 0.61 8.53 0.43 5.32e-16 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs490234 0.702 rs13302549 chr9:128284775 T/C cg14078157 chr9:128172775 NA -0.4 -6.58 -0.34 1.81e-10 Mean arterial pressure; CRC cis rs7567389 0.704 rs4662714 chr2:127995213 A/G cg06038358 chr2:128176007 PROC -0.34 -5.68 -0.3 2.89e-8 Self-rated health; CRC cis rs863345 0.604 rs10908656 chr1:158461016 A/G cg12129480 chr1:158549410 OR10X1 -0.29 -6.04 -0.32 4.2e-9 Pneumococcal bacteremia; CRC cis rs28386778 0.897 rs2854221 chr17:61941445 G/T cg06601766 chr17:61851465 DDX42;CCDC47 0.43 5.83 0.31 1.33e-8 Prudent dietary pattern; CRC cis rs28386778 0.897 rs2665795 chr17:61925272 A/G cg23090583 chr17:61904693 PSMC5;FTSJ3 -1.03 -20.32 -0.75 4.64e-60 Prudent dietary pattern; CRC cis rs59918340 0.728 rs4961340 chr8:142232002 G/A cg23750338 chr8:142222470 SLC45A4 0.6 11.04 0.52 2.6e-24 Immature fraction of reticulocytes; CRC cis rs9522267 0.535 rs9522302 chr13:112236874 C/T cg26182253 chr13:112236782 NA 0.31 6.23 0.32 1.4e-9 Hepatitis; CRC cis rs72781680 0.611 rs2303287 chr2:24302246 A/G cg20701182 chr2:24300061 SF3B14 -0.66 -7.9 -0.4 4.15e-14 Lymphocyte counts; CRC cis rs10504229 0.728 rs77197419 chr8:58150879 C/A cg24829409 chr8:58192753 C8orf71 -0.58 -7.96 -0.4 2.86e-14 Developmental language disorder (linguistic errors); CRC cis rs11148252 0.774 rs7334583 chr13:52930352 G/T cg12458913 chr13:53173898 NA -0.54 -8.56 -0.43 4.41e-16 Lewy body disease; CRC cis rs4243830 0.850 rs3761927 chr1:6601773 T/C cg22792644 chr1:6614718 TAS1R1;NOL9 -0.8 -9.66 -0.47 1.35e-19 Body mass index; CRC cis rs4925540 0.686 rs2642995 chr1:247172565 A/G cg22502715 chr1:247171572 ZNF695 0.41 6.07 0.32 3.46e-9 Response to taxane treatment (docetaxel); CRC cis rs55823223 0.503 rs9906971 chr17:73848477 A/G cg24416660 chr17:73865998 NA -0.38 -5.76 -0.3 1.91e-8 Psoriasis; CRC trans rs11148252 0.532 rs9526975 chr13:53255804 C/T cg18335740 chr13:41363409 SLC25A15 0.92 17.36 0.69 2.3e-48 Lewy body disease; CRC trans rs3806843 0.900 rs116210441 chr5:140128649 T/A cg06840491 chr10:48416966 GDF2 -0.35 -6.15 -0.32 2.2e-9 Depressive symptoms (multi-trait analysis); CRC cis rs7666738 0.830 rs3907021 chr4:99038668 C/T cg17366294 chr4:99064904 C4orf37 0.44 7.5 0.38 6.02e-13 Colonoscopy-negative controls vs population controls; CRC cis rs17376456 0.877 rs10476601 chr5:93402522 G/A cg09848695 chr5:92956644 FAM172A;MIR2277 0.61 5.68 0.3 2.95e-8 Diabetic retinopathy; CRC cis rs6484504 0.532 rs11031342 chr11:31309818 G/A cg14844989 chr11:31128820 NA -0.36 -6.29 -0.33 1.01e-9 Red blood cell count; CRC cis rs155076 0.938 rs261375 chr13:21871882 A/G cg25811766 chr13:21894605 NA 0.55 6.1 0.32 3.01e-9 White matter hyperintensity burden; CRC cis rs6496667 0.865 rs62019351 chr15:90926557 G/A cg04176472 chr15:90893244 GABARAPL3 0.58 7.58 0.39 3.62e-13 Rheumatoid arthritis; CRC cis rs4713118 0.866 rs2179094 chr6:27741825 T/C cg03623178 chr6:28175578 NA 0.72 9.61 0.47 2.04e-19 Parkinson's disease; CRC cis rs10751667 0.666 rs7396059 chr11:970490 C/A cg01483505 chr11:975446 AP2A2 0.46 7.65 0.39 2.2e-13 Alzheimer's disease (late onset); CRC cis rs4862750 0.832 rs6419953 chr4:187900509 T/A cg22105103 chr4:187893119 NA 0.64 11.71 0.54 1.01e-26 Lobe attachment (rater-scored or self-reported); CRC cis rs4713118 0.869 rs7773070 chr6:27728827 T/C cg06470822 chr6:28175283 NA 0.73 10.39 0.5 4.74e-22 Parkinson's disease; CRC cis rs1801251 0.727 rs13029336 chr2:233569935 A/G cg25237894 chr2:233734115 C2orf82 -0.45 -7.05 -0.36 1.03e-11 Coronary artery disease; CRC cis rs775227 0.574 rs13067967 chr3:113265215 C/G cg18753928 chr3:113234510 CCDC52 -0.59 -7.06 -0.36 1e-11 Dental caries; CRC trans rs208520 0.690 rs12192710 chr6:66718137 C/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 1.05 14.77 0.63 3.05e-38 Exhaled nitric oxide output; CRC cis rs2430307 0.556 rs3905501 chr7:76542080 C/T cg15770687 chr7:76625569 PMS2L11 -0.68 -7.89 -0.4 4.43e-14 Body mass index (joint analysis main effects and physical activity interaction);Body mass index;Body mass index in physically active individuals; CRC cis rs939584 1.000 rs7559447 chr2:645646 C/T cg03610516 chr2:642275 NA 0.42 5.88 0.31 9.94e-9 Body mass index; CRC cis rs7572644 0.640 rs6744348 chr2:28018025 A/C cg27432699 chr2:27873401 GPN1 0.45 5.64 0.3 3.65e-8 Response to carboplatin and paclitaxel in ovarian cancer (Caspase 3/7 EC50); CRC cis rs4727963 0.792 rs2402627 chr7:122728102 T/C cg03640110 chr7:122635026 TAS2R16 0.35 6.34 0.33 7.67e-10 Adverse response to chemotherapy (neutropenia/leucopenia) (docetaxel); CRC cis rs896854 0.552 rs2515236 chr8:95934907 A/G cg23172400 chr8:95962367 TP53INP1 0.4 6.04 0.32 4.07e-9 Type 2 diabetes; CRC cis rs35110281 0.782 rs1454650 chr21:45012353 C/T cg04455712 chr21:45112962 RRP1B 0.41 8.1 0.41 1.08e-14 Mean corpuscular volume; CRC cis rs875971 1.000 rs6460295 chr7:65882728 T/C cg18876405 chr7:65276391 NA 0.52 9.04 0.45 1.37e-17 Aortic root size; CRC cis rs826838 1.000 rs7299124 chr12:39002661 T/C cg13010199 chr12:38710504 ALG10B 0.44 5.8 0.3 1.52e-8 Heart rate; CRC cis rs6433857 0.594 rs17364750 chr2:181524361 C/G cg23363182 chr2:181467187 NA -0.46 -7.24 -0.37 3.2e-12 Body mass index; CRC trans rs7395662 0.963 rs10769389 chr11:48618011 C/T cg21153622 chr11:89784906 NA -0.45 -7.22 -0.37 3.57e-12 HDL cholesterol; CRC cis rs4481887 1.000 rs4244182 chr1:248471174 A/G cg00666640 chr1:248458726 OR2T12 0.54 9.63 0.47 1.74e-19 Common traits (Other); CRC cis rs1401999 1.000 rs13317532 chr3:183641669 G/C cg05044414 chr3:183734942 ABCC5 0.48 8.3 0.42 2.71e-15 Anterior chamber depth; CRC cis rs1570884 0.516 rs2094108 chr13:50171550 G/A cg08779649 chr13:50194554 NA 0.44 9.21 0.45 4.03e-18 Sum basophil neutrophil counts;Sum neutrophil eosinophil counts;Neutrophil count;Myeloid white cell count;Granulocyte count; CRC cis rs1336900 0.544 rs10888386 chr1:150611957 A/G cg10589385 chr1:150898437 SETDB1 -0.31 -6.57 -0.34 1.93e-10 Blood protein levels; CRC cis rs6963495 0.818 rs73192115 chr7:105169605 T/A cg13798780 chr7:105162888 PUS7 0.68 8.04 0.41 1.59e-14 Bipolar disorder (body mass index interaction); CRC cis rs35306767 0.903 rs35637113 chr10:874149 G/C cg26597838 chr10:835615 NA 0.96 11.44 0.53 9.55e-26 Eosinophil percentage of granulocytes; CRC cis rs7208859 0.673 rs9894876 chr17:29182020 G/A cg14008862 chr17:28927542 LRRC37B2 0.55 5.74 0.3 2.1e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs2658782 0.951 rs117384439 chr11:93111478 T/G cg15737290 chr11:93063684 CCDC67 -0.51 -7.34 -0.37 1.74e-12 Pulmonary function decline; CRC cis rs2204008 0.623 rs4882302 chr12:38415608 T/A cg13010199 chr12:38710504 ALG10B -0.4 -5.62 -0.3 3.99e-8 Bladder cancer; CRC cis rs7085104 0.660 rs3781286 chr10:104595719 C/T cg08772003 chr10:104629869 AS3MT -0.37 -6.44 -0.33 4.33e-10 Immature fraction of reticulocytes;Schizophrenia; CRC cis rs72901758 0.768 rs1567237 chr17:76246294 A/G cg26068271 chr17:76253126 NA -0.39 -5.98 -0.31 5.77e-9 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells; CRC cis rs1532331 1.000 rs1532331 chr5:43116830 G/T cg09164108 chr5:43007320 NA 0.41 6.22 0.32 1.48e-9 Menarche (age at onset); CRC cis rs7605827 0.930 rs13398393 chr2:15602804 T/G cg19274914 chr2:15703543 NA 0.38 5.78 0.3 1.73e-8 Educational attainment (years of education); CRC cis rs4713118 0.513 rs149945 chr6:28002853 T/C cg10876282 chr6:28092338 ZSCAN16 0.46 6.3 0.33 9.74e-10 Parkinson's disease; CRC cis rs56104184 0.775 rs55737338 chr19:49403141 A/G cg21252483 chr19:49399788 TULP2 -0.43 -6.52 -0.34 2.59e-10 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; CRC cis rs6502050 0.835 rs7220639 chr17:80146866 G/A cg02741985 chr17:80059408 CCDC57 0.44 7.33 0.37 1.76e-12 Life satisfaction; CRC trans rs11225569 0.539 rs11225820 chr11:103342925 T/C cg01615333 chr12:127765195 NA -0.65 -6.17 -0.32 1.98e-9 Diisocyanate-induced asthma; CRC cis rs17152411 1.000 rs1807099 chr10:126593774 C/T cg07906193 chr10:126599966 NA 0.58 6.52 0.34 2.69e-10 Height; CRC cis rs4253772 0.637 rs56017104 chr22:46651982 A/G cg24881330 chr22:46731750 TRMU 0.57 5.7 0.3 2.61e-8 LDL cholesterol;Cholesterol, total; CRC cis rs3806843 0.897 rs2531338 chr5:140136957 A/T cg16607685 chr5:140181889 PCDHA2;PCDHA1;PCDHA3 0.26 5.92 0.31 8.25e-9 Depressive symptoms (multi-trait analysis); CRC trans rs28643277 0.671 rs7085504 chr10:15555319 C/G cg18315834 chr14:64909119 MTHFD1 0.42 6.13 0.32 2.48e-9 Periodontitis (CDC/AAP); CRC cis rs7827545 0.961 rs4909482 chr8:135564786 G/T cg13086574 chr8:135490821 ZFAT -0.36 -6.08 -0.32 3.34e-9 Hypertension (SNP x SNP interaction); CRC cis rs7487075 0.647 rs12580583 chr12:46707001 C/G cg22049899 chr12:47219821 SLC38A4 0.34 6.54 0.34 2.31e-10 Itch intensity from mosquito bite; CRC cis rs7937682 0.961 rs11828343 chr11:111491322 A/G cg09085632 chr11:111637200 PPP2R1B 1.01 17.81 0.7 3.74e-50 Primary sclerosing cholangitis; CRC cis rs1862618 0.853 rs832569 chr5:56154584 T/A cg12311346 chr5:56204834 C5orf35 -0.8 -10.27 -0.49 1.24e-21 Initial pursuit acceleration; CRC cis rs3750082 0.889 rs55647647 chr7:32935020 C/T cg05721444 chr7:32995514 FKBP9 0.49 7.46 0.38 7.87e-13 Glomerular filtration rate (creatinine); CRC cis rs7584330 0.554 rs1343768 chr2:238444881 G/A cg14458575 chr2:238380390 NA 0.52 7.24 0.37 3.16e-12 Prostate cancer; CRC cis rs7020830 0.898 rs7846747 chr9:37167539 A/C cg14294708 chr9:37120828 ZCCHC7 1.2 27.12 0.83 7.09e-86 Schizophrenia; CRC cis rs1760803 0.701 rs6427509 chr1:154219718 C/T cg26808167 chr1:154192205 UBAP2L;C1orf43 -0.34 -5.94 -0.31 7.2e-9 Nicotine dependence; CRC cis rs861020 0.606 rs2184919 chr1:210000015 C/T cg09163369 chr1:210001066 C1orf107 -0.41 -5.67 -0.3 3.2e-8 Orofacial clefts; CRC cis rs1005277 0.505 rs200939 chr10:38139483 T/C cg25427524 chr10:38739819 LOC399744 -0.73 -12.73 -0.57 1.93e-30 Extrinsic epigenetic age acceleration; CRC cis rs798554 0.567 rs2527695 chr7:2858267 T/G cg13628971 chr7:2884303 GNA12 0.43 6.66 0.34 1.15e-10 Height; CRC trans rs7618501 0.966 rs9882639 chr3:49799475 A/C cg21582582 chr3:182698605 DCUN1D1 0.55 8.02 0.4 1.84e-14 Intelligence (multi-trait analysis); CRC cis rs9937943 0.512 rs13335886 chr16:74577161 C/G cg01733217 chr16:74700730 RFWD3 -0.69 -8.53 -0.43 5.49e-16 Neutrophil percentage of white cells; CRC cis rs7937682 0.632 rs11214028 chr11:111761149 T/C cg09085632 chr11:111637200 PPP2R1B 0.95 15.13 0.64 1.25e-39 Primary sclerosing cholangitis; CRC cis rs62064224 0.589 rs2285428 chr17:30820176 C/T cg25809561 chr17:30822961 MYO1D -0.56 -9.87 -0.48 2.74e-20 Schizophrenia; CRC cis rs887829 0.570 rs4347832 chr2:234593041 T/C cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.49 -7.61 -0.39 2.98e-13 Metabolic traits;Bilirubin levels;Cholelithiasis-related traits in sickle cell anemia;Metabolite levels;Total bilirubin levels in HIV-1 infection;Serum metabolite levels;Blood metabolite levels; CRC cis rs6952809 0.532 rs10227362 chr7:2456799 A/G cg23289794 chr7:2394357 EIF3B -0.71 -8.62 -0.43 2.91e-16 Multiple sclerosis; CRC cis rs1401999 1.000 rs2872249 chr3:183636273 T/A cg05044414 chr3:183734942 ABCC5 0.48 8.24 0.41 4.1e-15 Anterior chamber depth; CRC cis rs2239547 0.603 rs2276825 chr3:52886605 T/C cg15147215 chr3:52552868 STAB1 -0.41 -5.78 -0.3 1.72e-8 Schizophrenia; CRC trans rs2303319 0.504 rs12470743 chr2:162611202 G/A cg20024234 chr21:43431083 ZNF295 -0.66 -5.99 -0.31 5.57e-9 Cognitive function; CRC cis rs3617 0.573 rs9850563 chr3:52912214 G/A cg18099408 chr3:52552593 STAB1 0.35 6.01 0.31 4.95e-9 Red blood cell count;Autism spectrum disorder or schizophrenia; CRC cis rs6460942 0.822 rs13340498 chr7:12233877 G/T cg06484146 chr7:12443880 VWDE -0.58 -6.08 -0.32 3.36e-9 Coronary artery disease; CRC cis rs10751667 1.000 rs10902233 chr11:925510 A/G cg01483505 chr11:975446 AP2A2 0.4 5.92 0.31 8.22e-9 Alzheimer's disease (late onset); CRC cis rs929596 0.606 rs10178992 chr2:234657877 T/A cg02227331 chr2:234663937 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 0.43 6.37 0.33 6.37e-10 Total bilirubin levels in HIV-1 infection; CRC cis rs1862618 0.853 rs2548665 chr5:56131805 T/A cg18230493 chr5:56204884 C5orf35 -0.71 -9.19 -0.45 4.44e-18 Initial pursuit acceleration; CRC cis rs933688 1.000 rs7715402 chr5:90679504 T/A cg02339078 chr5:90679543 LOC100129716;ARRDC3 0.9 15.28 0.64 3.35e-40 Smoking behavior; CRC cis rs6502050 0.835 rs8078950 chr17:80122327 T/G cg25804541 chr17:80189381 SLC16A3 -0.31 -5.95 -0.31 6.84e-9 Life satisfaction; CRC cis rs12134245 0.747 rs17501512 chr1:92012481 C/G cg21854759 chr1:92012499 NA 0.53 8.9 0.44 3.72e-17 Breast cancer; CRC cis rs651907 0.514 rs11706494 chr3:101509475 A/T cg11279151 chr3:101281821 RG9MTD1 -0.53 -7.08 -0.36 8.95e-12 Colorectal cancer; CRC cis rs4713118 0.869 rs2056925 chr6:27690905 A/G cg08798685 chr6:27730294 NA -0.42 -6.06 -0.32 3.72e-9 Parkinson's disease; CRC cis rs1218582 0.596 rs11264275 chr1:154825270 G/T cg09359103 chr1:154839909 KCNN3 0.56 8.64 0.43 2.5e-16 Prostate cancer; CRC cis rs801193 1.000 rs11773829 chr7:66141074 G/A cg11764359 chr7:65958608 NA -0.55 -8.41 -0.42 1.26e-15 Aortic root size; CRC cis rs9487051 0.768 rs351729 chr6:109511668 T/C cg21918786 chr6:109611834 NA 0.36 6.23 0.32 1.41e-9 Reticulocyte fraction of red cells; CRC cis rs4665809 0.531 rs12987980 chr2:26462093 A/T cg08067268 chr2:26466485 HADHB;HADHA 0.66 8.38 0.42 1.54e-15 Gut microbiome composition (summer); CRC cis rs8180040 0.764 rs11718795 chr3:47218727 G/A cg02527881 chr3:46936655 PTH1R -0.4 -7.48 -0.38 6.62e-13 Colorectal cancer; CRC cis rs952623 0.501 rs12671046 chr7:39081866 C/T cg18850127 chr7:39170497 POU6F2 -0.43 -5.61 -0.3 4.26e-8 Intelligence (multi-trait analysis); CRC cis rs6933660 0.683 rs6916340 chr6:151779064 T/C cg02564969 chr6:151773285 C6orf211;RMND1 0.43 6.15 0.32 2.25e-9 Menarche (age at onset); CRC cis rs7617773 0.815 rs7624450 chr3:48350375 A/G cg11946769 chr3:48343235 NME6 0.73 9.78 0.47 5.39e-20 Coronary artery disease; CRC cis rs7945705 0.905 rs7947631 chr11:8844909 A/G cg21881798 chr11:8931708 C11orf17;ST5 -0.45 -6.6 -0.34 1.62e-10 Hemoglobin concentration; CRC cis rs9902453 0.765 rs3102562 chr17:28040403 C/T cg26525008 chr17:28256777 EFCAB5;SSH2 0.7 11.72 0.54 9.5e-27 Coffee consumption (cups per day); CRC cis rs9911578 0.967 rs3826353 chr17:57075299 C/T cg05425664 chr17:57184151 TRIM37 -0.52 -8.02 -0.4 1.85e-14 Intelligence (multi-trait analysis); CRC cis rs7586879 0.964 rs4077680 chr2:25122942 A/G cg22495460 chr2:25135724 ADCY3 -0.72 -11.83 -0.55 3.81e-27 Body mass index; CRC cis rs7666738 0.830 rs62318472 chr4:98926030 G/A cg17366294 chr4:99064904 C4orf37 0.43 7.2 0.37 4.22e-12 Colonoscopy-negative controls vs population controls; CRC cis rs798554 0.634 rs6978692 chr7:2857411 C/T cg13628971 chr7:2884303 GNA12 0.43 6.7 0.35 9.13e-11 Height; CRC cis rs9787249 0.957 rs3738673 chr1:40204823 C/T cg01941586 chr1:40203715 PPIE -0.46 -6.34 -0.33 7.56e-10 Blood protein levels; CRC cis rs67311347 1.000 rs7628796 chr3:40507332 G/A cg09455208 chr3:40491958 NA -0.47 -9.33 -0.46 1.59e-18 Renal cell carcinoma; CRC cis rs875971 0.723 rs28391294 chr7:65654315 T/C cg00343986 chr7:65444356 GUSB -0.42 -5.98 -0.31 5.8e-9 Aortic root size; CRC cis rs6860806 0.507 rs2631369 chr5:131705266 G/C cg18758796 chr5:131593413 PDLIM4 -0.42 -6.92 -0.36 2.44e-11 Breast cancer; CRC cis rs904251 0.523 rs2776870 chr6:37481364 C/A cg25019722 chr6:37503610 NA -0.47 -8.77 -0.44 9.97e-17 Cognitive performance; CRC cis rs6951245 1.000 rs74887741 chr7:1110658 G/T cg18402987 chr7:1209562 NA 0.67 7.21 0.37 3.81e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg05730215 chr2:27435253 SLC5A6;C2orf28 0.42 6.53 0.34 2.43e-10 Obesity-related traits; CRC cis rs780096 0.526 rs72819536 chr2:27682850 G/T cg21248554 chr2:27665150 KRTCAP3 -0.33 -7.3 -0.37 2.24e-12 Total body bone mineral density; CRC cis rs1008375 1.000 rs1860597 chr4:17657650 C/T cg02297831 chr4:17616191 MED28 0.44 5.93 0.31 7.73e-9 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs6831352 0.918 rs29001202 chr4:100053782 T/A cg13256891 chr4:100009986 ADH5 -0.65 -8.72 -0.43 1.42e-16 Alcohol dependence; CRC cis rs644799 0.965 rs10831426 chr11:95505888 G/A cg25478527 chr11:95522999 CEP57;FAM76B 0.52 7.75 0.39 1.15e-13 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs743757 1.000 rs2236965 chr3:50453456 T/C cg08207895 chr3:50388901 TUSC4;CYB561D2 0.45 6.58 0.34 1.84e-10 Diastolic blood pressure; CRC cis rs6534441 0.857 rs6821873 chr4:125462941 G/A cg21609808 chr4:125404261 NA 0.39 5.77 0.3 1.85e-8 Major depressive disorder; CRC cis rs703842 0.616 rs10783850 chr12:58229377 T/C cg00677455 chr12:58241039 CTDSP2 0.82 11.69 0.54 1.26e-26 Multiple sclerosis; CRC cis rs2153535 0.541 rs9379207 chr6:8458186 C/T cg21535247 chr6:8435926 SLC35B3 0.51 7.9 0.4 4.36e-14 Motion sickness; CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg25667490 chr4:72052924 SLC4A4 0.36 6.24 0.33 1.37e-9 Obesity-related traits; CRC cis rs4713118 0.662 rs149947 chr6:27972433 A/T cg15786705 chr6:28176104 NA 0.69 9.84 0.48 3.5e-20 Parkinson's disease; CRC cis rs4285028 0.948 rs71329246 chr3:121680170 T/C cg20356878 chr3:121714668 ILDR1 -0.48 -7.0 -0.36 1.45e-11 Multiple sclerosis; CRC trans rs12599106 0.624 rs2173885 chr16:34992749 G/A cg26668828 chr6:292823 DUSP22 -0.68 -10.07 -0.49 5.54e-21 Menopause (age at onset); CRC cis rs6952808 0.825 rs34922657 chr7:1938655 C/T cg22963979 chr7:1858916 MAD1L1 -0.51 -7.59 -0.39 3.41e-13 Bipolar disorder and schizophrenia; CRC cis rs561341 1.000 rs8073186 chr17:30244956 T/C cg23018236 chr17:30244563 NA -0.46 -6.26 -0.33 1.21e-9 Hip circumference adjusted for BMI; CRC cis rs17401966 0.597 rs6667639 chr1:10246471 C/A cg19773385 chr1:10388646 KIF1B -0.52 -8.0 -0.4 2.11e-14 Hepatocellular carcinoma; CRC cis rs9430161 0.579 rs7542164 chr1:11040223 G/A cg02454025 chr1:11042201 C1orf127 0.9 14.49 0.62 3.98e-37 Ewing sarcoma; CRC trans rs2303319 0.582 rs62188151 chr2:162309849 C/A cg19471553 chr17:41393123 NA -0.7 -6.07 -0.32 3.48e-9 Cognitive function; CRC cis rs2067615 0.579 rs10507214 chr12:107194461 G/A cg13491945 chr12:107078410 RFX4 0.35 6.0 0.31 5.34e-9 Heart rate; CRC cis rs2762353 0.595 rs12207270 chr6:25751721 A/G cg07061783 chr6:25882402 NA -0.49 -6.44 -0.33 4.12e-10 Blood metabolite levels; CRC trans rs6472235 0.837 rs10092435 chr8:66936177 A/G cg07884673 chr3:53033167 SFMBT1 -0.45 -6.03 -0.32 4.47e-9 Myopia (pathological);Plateletcrit; CRC cis rs8022179 0.580 rs58153827 chr14:103844630 G/A cg12935359 chr14:103987150 CKB 0.55 7.34 0.37 1.73e-12 Monocyte count; CRC cis rs863345 0.604 rs10797018 chr1:158490112 G/A cg12129480 chr1:158549410 OR10X1 -0.3 -6.25 -0.33 1.25e-9 Pneumococcal bacteremia; CRC cis rs9435341 0.965 rs56111229 chr1:107566689 T/A cg15468180 chr1:107600409 PRMT6 0.38 5.74 0.3 2.12e-8 Facial morphology (factor 21, depth of nasal alae); CRC cis rs9322193 0.962 rs9322223 chr6:150122645 G/A cg04369109 chr6:150039330 LATS1 -0.43 -6.03 -0.32 4.38e-9 Lung cancer; CRC cis rs9916302 0.861 rs632202 chr17:37453294 C/A cg15445000 chr17:37608096 MED1 -0.41 -9.01 -0.44 1.72e-17 Glomerular filtration rate (creatinine); CRC cis rs12594515 1.000 rs8033148 chr15:45997929 G/A cg06207120 chr15:45996521 NA 0.31 7.54 0.38 4.48e-13 Waist circumference;Weight; CRC cis rs4665809 0.590 rs1049987 chr2:26413817 C/T cg04944784 chr2:26401820 FAM59B 0.84 10.6 0.5 9.17e-23 Gut microbiome composition (summer); CRC cis rs1799949 0.501 rs9675035 chr17:41415016 A/T cg05368731 chr17:41323189 NBR1 0.67 10.08 0.49 5.26e-21 Menopause (age at onset); CRC cis rs909674 0.865 rs5757682 chr22:39848259 T/G cg24399712 chr22:39784796 NA -0.41 -7.71 -0.39 1.55e-13 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; CRC cis rs853679 0.666 rs200956 chr6:27839746 A/G cg26587870 chr6:27730563 NA -0.43 -5.69 -0.3 2.75e-8 Depression; CRC cis rs4819052 0.788 rs4819051 chr21:46693128 C/T cg11663144 chr21:46675770 NA -0.85 -14.55 -0.63 2.21e-37 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs8060686 0.641 rs75297764 chr16:68212820 C/T cg08314208 chr16:67682810 RLTPR -0.54 -5.94 -0.31 7.18e-9 HDL cholesterol;Metabolic syndrome; CRC trans rs61931739 0.500 rs7313094 chr12:34457508 T/C cg13010199 chr12:38710504 ALG10B 0.46 6.5 0.34 3.07e-10 Morning vs. evening chronotype; CRC cis rs8177253 1.000 rs6439439 chr3:133481498 G/T cg08048268 chr3:133502702 NA -0.36 -6.76 -0.35 6.12e-11 Iron status biomarkers; CRC cis rs2019137 0.539 rs4849177 chr2:113982584 T/C cg23564664 chr2:113997917 PAX8;LOC654433;LOC440839 -0.36 -5.98 -0.31 5.87e-9 Lymphocyte counts; CRC cis rs4237845 0.816 rs61935769 chr12:58294344 G/A cg00677455 chr12:58241039 CTDSP2 0.66 9.16 0.45 5.51e-18 Intelligence (multi-trait analysis); CRC cis rs898097 0.578 rs9906163 chr17:80908174 T/C cg15664640 chr17:80829946 TBCD 0.47 7.87 0.4 5.31e-14 Breast cancer; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg24008668 chr6:26158556 HIST1H2BD 0.41 6.26 0.33 1.22e-9 Liver disease severity in Alagille syndrome; CRC cis rs9640161 0.659 rs77354576 chr7:150013300 A/C cg12556325 chr7:150026731 C7orf29;LRRC61 -0.41 -6.49 -0.34 3.09e-10 Blood protein levels;Circulating chemerin levels; CRC cis rs7605827 0.930 rs6720900 chr2:15688281 T/C cg19274914 chr2:15703543 NA 0.38 5.8 0.3 1.59e-8 Educational attainment (years of education); CRC cis rs6088580 0.634 rs62212172 chr20:32987705 G/A cg24642439 chr20:33292090 TP53INP2 -0.38 -6.39 -0.33 5.8e-10 Glomerular filtration rate (creatinine); CRC trans rs17560407 0.620 rs13159808 chr5:88194669 T/A cg11144641 chr5:134871566 NEUROG1 0.34 5.99 0.31 5.37e-9 Thiazide-induced adverse metabolic effects in hypertensive patients; CRC cis rs57221529 0.766 rs72706610 chr5:561111 G/A cg17948913 chr5:572064 NA 0.55 6.25 0.33 1.3e-9 Lung disease severity in cystic fibrosis; CRC cis rs7618915 0.547 rs11130314 chr3:52697082 T/C cg15147215 chr3:52552868 STAB1 -0.63 -10.4 -0.5 4.44e-22 Bipolar disorder; CRC cis rs832540 0.603 rs6870175 chr5:56093371 A/G cg12311346 chr5:56204834 C5orf35 -0.5 -7.49 -0.38 6.27e-13 Coronary artery disease; CRC cis rs4727027 0.704 rs13221837 chr7:148903597 C/T cg23583168 chr7:148888333 NA -0.91 -17.23 -0.69 7.42e-48 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC trans rs2303319 0.504 rs62189046 chr2:162612371 C/G cg22627826 chr19:1240265 ATP5D -0.72 -6.24 -0.33 1.32e-9 Cognitive function; CRC cis rs2294693 0.945 rs11756893 chr6:41010058 A/C cg14769373 chr6:40998127 UNC5CL -0.47 -6.03 -0.32 4.3e-9 Gastric cancer;Non-cardia gastric cancer; CRC trans rs10983614 1.000 rs7867776 chr9:120072627 A/G cg10667969 chr3:149181941 NA 0.45 6.08 0.32 3.36e-9 Survival in pancreatic cancer; CRC cis rs3733585 0.699 rs6449177 chr4:9968050 T/C cg11266682 chr4:10021025 SLC2A9 -0.46 -9.35 -0.46 1.37e-18 Cleft plate (environmental tobacco smoke interaction); CRC cis rs990171 1.000 rs3755267 chr2:103038587 G/T cg03938978 chr2:103052716 IL18RAP -0.46 -5.76 -0.3 1.92e-8 Lymphocyte counts; CRC cis rs13108904 0.870 rs4974545 chr4:1271923 C/T cg02018176 chr4:1364513 KIAA1530 0.44 7.24 0.37 3.16e-12 Obesity-related traits; CRC trans rs9329221 0.651 rs2975648 chr8:10135976 C/T cg08975724 chr8:8085496 FLJ10661 -0.48 -7.45 -0.38 8.1e-13 Neuroticism; CRC trans rs2727020 0.575 rs10769587 chr11:49549849 C/G cg03929089 chr4:120376271 NA -0.92 -16.74 -0.68 6.08e-46 Coronary artery disease; CRC cis rs9308731 0.666 rs4849402 chr2:111873932 G/A cg18646521 chr2:111875858 NA 0.36 5.63 0.3 3.77e-8 Chronic lymphocytic leukemia; CRC cis rs4713118 0.597 rs172166 chr6:28020820 C/G cg15786705 chr6:28176104 NA 0.67 9.29 0.46 2.23e-18 Parkinson's disease; CRC cis rs8014204 0.570 rs7147721 chr14:75186010 A/G cg03030879 chr14:75389066 RPS6KL1 -0.52 -8.31 -0.42 2.56e-15 Caffeine consumption; CRC cis rs9381040 0.655 rs2268190 chr6:41030226 C/T cg09580153 chr6:41068724 NFYA;LOC221442 -0.43 -6.28 -0.33 1.1e-9 Alzheimer's disease (late onset); CRC cis rs3741404 0.665 rs12418535 chr11:63910980 A/G cg19465662 chr11:63993652 NUDT22;TRPT1 0.85 13.85 0.61 1.09e-34 Platelet count; CRC cis rs7605827 0.897 rs2380650 chr2:15533689 T/C cg19274914 chr2:15703543 NA 0.39 5.88 0.31 9.87e-9 Educational attainment (years of education); CRC cis rs710216 0.879 rs710218 chr1:43427218 A/T cg03128534 chr1:43423976 SLC2A1 0.47 6.42 0.33 4.86e-10 Red cell distribution width; CRC cis rs713477 0.505 rs1953740 chr14:55886717 G/A cg13175173 chr14:55914753 NA -0.45 -7.26 -0.37 2.78e-12 Pediatric bone mineral content (femoral neck); CRC cis rs6089584 0.927 rs2296083 chr20:60574216 C/T cg18761221 chr20:60518478 NA 0.41 7.39 0.38 1.26e-12 Body mass index; CRC trans rs1814175 0.817 rs1319547 chr11:49916705 C/T cg03929089 chr4:120376271 NA -0.94 -17.84 -0.7 2.9e-50 Height; CRC cis rs2050392 0.590 rs694346 chr10:30711929 C/T cg18806716 chr10:30721971 MAP3K8 -0.69 -10.03 -0.48 7.8e-21 Inflammatory bowel disease; CRC cis rs2228479 0.764 rs7191836 chr16:89961597 T/C cg06656553 chr16:89960601 TCF25 -0.56 -5.7 -0.3 2.62e-8 Skin colour saturation; CRC cis rs10193935 0.901 rs12622153 chr2:42598386 C/A cg27598129 chr2:42591480 NA -0.69 -7.82 -0.4 7.11e-14 Colonoscopy-negative controls vs population controls; CRC cis rs736408 0.522 rs6445535 chr3:52771468 T/C cg18099408 chr3:52552593 STAB1 -0.47 -7.89 -0.4 4.59e-14 Bipolar disorder; CRC cis rs9914988 0.943 rs67327562 chr17:27108828 G/A cg07195577 chr17:27052828 TLCD1 0.42 6.06 0.32 3.63e-9 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs2786111 1.000 rs550098 chr1:197297408 A/G cg13682187 chr1:196946512 CFHR5 0.29 5.71 0.3 2.52e-8 Lupus nephritis in systemic lupus erythematosus; CRC trans rs877282 0.853 rs11253332 chr10:755262 G/C cg22713356 chr15:30763199 NA 1.19 13.88 0.61 8.17e-35 Uric acid levels; CRC trans rs4942242 0.663 rs17460812 chr13:44215504 A/G cg27382691 chr15:76552771 ETFA;TYRO3P -0.46 -6.33 -0.33 8.19e-10 Response to tocilizumab in rheumatoid arthritis; CRC cis rs4713118 0.955 rs9380011 chr6:27683924 A/G cg03623178 chr6:28175578 NA 0.63 8.4 0.42 1.36e-15 Parkinson's disease; CRC cis rs2050392 0.630 rs303428 chr10:30739058 C/T cg18806716 chr10:30721971 MAP3K8 0.46 6.45 0.34 3.91e-10 Inflammatory bowel disease; CRC trans rs7395662 0.591 rs4882110 chr11:48558249 G/T cg03929089 chr4:120376271 NA -0.46 -6.53 -0.34 2.51e-10 HDL cholesterol; CRC cis rs362272 0.545 rs2749785 chr4:3325179 G/C cg11522145 chr4:3412961 RGS12 -0.41 -6.39 -0.33 5.74e-10 Serum sulfate level; CRC cis rs881375 0.967 rs10739579 chr9:123694788 C/A cg09586646 chr9:123605570 PSMD5;LOC253039 0.47 6.49 0.34 3.2e-10 Rheumatoid arthritis; CRC cis rs1153858 1.000 rs1554521 chr15:45664189 A/T cg10760299 chr15:45669010 GATM -0.49 -7.59 -0.39 3.39e-13 Homoarginine levels; CRC trans rs58688157 0.705 rs2396545 chr11:601785 T/C cg19188899 chr13:112838565 NA -0.39 -6.26 -0.33 1.23e-9 Systemic lupus erythematosus; CRC cis rs2652822 1.000 rs1126308 chr15:63429086 G/T cg02713581 chr15:63449717 RPS27L -0.4 -5.99 -0.31 5.51e-9 Metabolic traits; CRC cis rs919433 0.929 rs7592511 chr2:198177974 A/G cg20885578 chr2:198174922 NA -0.39 -7.04 -0.36 1.11e-11 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC trans rs10506458 0.915 rs998506 chr12:63400017 C/T cg03429785 chr15:59498649 MYO1E;LDHAL6B -1.42 -21.1 -0.76 4.36e-63 Hemostatic factors and hematological phenotypes; CRC cis rs28386778 0.830 rs2665798 chr17:61921397 C/T cg23090583 chr17:61904693 PSMC5;FTSJ3 1.05 20.55 0.75 5.84e-61 Prudent dietary pattern; CRC cis rs1577917 0.839 rs12055653 chr6:86546663 A/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.44 -5.8 -0.3 1.52e-8 Response to antipsychotic treatment; CRC trans rs875971 0.660 rs2191268 chr7:66110224 C/T cg06751597 chr15:42788175 SNAP23 -0.41 -6.49 -0.34 3.25e-10 Aortic root size; CRC cis rs9814567 1.000 rs9883753 chr3:134247231 T/C cg06109529 chr3:134205091 CEP63;ANAPC13 -0.8 -11.99 -0.55 9.75e-28 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs736408 0.812 rs1076425 chr3:52825462 A/G cg15147215 chr3:52552868 STAB1 -0.54 -7.78 -0.39 9.45e-14 Bipolar disorder; CRC cis rs7666738 0.830 rs10007872 chr4:99001904 T/C cg05340658 chr4:99064831 C4orf37 0.58 8.94 0.44 2.79e-17 Colonoscopy-negative controls vs population controls; CRC cis rs9916302 0.904 rs6503519 chr17:37706578 A/G cg07936489 chr17:37558343 FBXL20 -0.86 -13.74 -0.6 2.87e-34 Glomerular filtration rate (creatinine); CRC cis rs1153858 1.000 rs12101539 chr15:45650666 C/G cg14582100 chr15:45693742 SPATA5L1 0.29 6.07 0.32 3.6e-9 Homoarginine levels; CRC cis rs4285028 0.747 rs3772126 chr3:121354583 G/A cg20356878 chr3:121714668 ILDR1 -0.43 -5.9 -0.31 8.89e-9 Multiple sclerosis; CRC cis rs10046574 0.656 rs76799185 chr7:135194266 G/C cg27474649 chr7:135195673 CNOT4 0.67 6.16 0.32 2.14e-9 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs8020095 0.571 rs10142059 chr14:67482629 A/G cg00791868 chr14:66963628 C14orf53 0.49 6.32 0.33 8.33e-10 Depression (quantitative trait); CRC trans rs6951245 0.872 rs75398423 chr7:1098414 T/G cg13565492 chr6:43139072 SRF -0.72 -7.44 -0.38 8.63e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs79976124 0.879 rs17511467 chr6:66627293 T/C cg07460842 chr6:66804631 NA 0.76 9.41 0.46 8.96e-19 Type 2 diabetes; CRC cis rs4970988 0.527 rs12067556 chr1:150614535 G/A cg10589385 chr1:150898437 SETDB1 0.32 6.72 0.35 7.83e-11 Urate levels; CRC cis rs270601 0.633 rs4535443 chr5:131572561 A/G cg27615366 chr5:131592974 PDLIM4 0.34 6.15 0.32 2.29e-9 Acylcarnitine levels; CRC cis rs9828933 0.577 rs832193 chr3:63854445 C/T cg16258503 chr3:63850278 ATXN7;THOC7 0.81 9.4 0.46 9.83e-19 Type 2 diabetes; CRC cis rs375066 0.592 rs349048 chr19:44300937 C/T cg12072164 chr19:44306565 LYPD5 -0.39 -6.3 -0.33 9.43e-10 Breast cancer; CRC cis rs9549367 0.789 rs9549361 chr13:113898329 C/T cg18105134 chr13:113819100 PROZ 0.7 9.8 0.48 4.57e-20 Platelet distribution width; CRC cis rs2204008 0.606 rs6582502 chr12:38543352 C/T cg13010199 chr12:38710504 ALG10B -0.42 -6.05 -0.32 3.97e-9 Bladder cancer; CRC cis rs2760061 0.784 rs708116 chr1:228198196 C/A cg02753203 chr1:228287806 NA 0.69 10.74 0.51 2.99e-23 Diastolic blood pressure; CRC cis rs694739 0.628 rs538147 chr11:64129722 G/A cg02228329 chr11:64053129 BAD;GPR137 0.48 6.74 0.35 7.01e-11 Alopecia areata;Crohn's disease;Psoriasis vulgaris; CRC cis rs2404602 0.647 rs11631959 chr15:77040048 T/C cg23625390 chr15:77176239 SCAPER -0.87 -14.42 -0.62 7.34e-37 Blood metabolite levels; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg04703227 chr1:19923504 C1orf151 0.4 6.92 0.36 2.43e-11 Liver disease severity in Alagille syndrome; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg17697381 chr3:148709363 GYG1 0.4 5.96 0.31 6.51e-9 Intelligence (multi-trait analysis); CRC cis rs7833790 0.700 rs7834483 chr8:82704828 A/G cg17211192 chr8:82754475 SNX16 -0.45 -6.09 -0.32 3.11e-9 Diastolic blood pressure; CRC cis rs738322 0.805 rs2016755 chr22:38539604 A/G cg25457927 chr22:38595422 NA -0.33 -6.93 -0.36 2.24e-11 Cutaneous nevi; CRC cis rs2032447 0.714 rs129129 chr6:25961029 A/G cg03264133 chr6:25882463 NA -0.52 -7.46 -0.38 7.87e-13 Intelligence (multi-trait analysis); CRC cis rs9487051 0.872 rs9374079 chr6:109609619 A/G cg01475377 chr6:109611718 NA -0.49 -9.34 -0.46 1.52e-18 Reticulocyte fraction of red cells; CRC cis rs2243480 0.831 rs7806717 chr7:65393174 A/G cg18252515 chr7:66147081 NA 1.08 12.66 0.57 3.44e-30 Diabetic kidney disease; CRC cis rs1552244 1.000 rs7628448 chr3:10146828 G/A cg18598329 chr3:10140678 FANCD2;C3orf24 -0.86 -10.99 -0.52 3.82e-24 Alzheimer's disease; CRC cis rs4664308 0.692 rs13009231 chr2:160964057 G/T cg03641300 chr2:160917029 PLA2R1 -0.57 -9.16 -0.45 5.5e-18 Idiopathic membranous nephropathy; CRC cis rs1215050 0.791 rs1025201 chr4:98902938 A/G cg05340658 chr4:99064831 C4orf37 -0.49 -7.47 -0.38 7.23e-13 Waist-to-hip ratio adjusted for body mass index; CRC cis rs9733 0.519 rs1336900 chr1:150679033 C/T cg18016565 chr1:150552671 MCL1 0.44 6.44 0.33 4.19e-10 Tonsillectomy; CRC cis rs6912958 0.781 rs9450723 chr6:88226641 C/T cg12350822 chr6:88032061 C6orf162;GJB7 0.34 6.42 0.33 4.89e-10 Monocyte percentage of white cells; CRC cis rs7192380 0.639 rs12448486 chr16:69802878 G/A cg04110750 chr16:69646130 NFAT5 0.4 6.04 0.32 4.28e-9 Sjögren's syndrome; CRC cis rs2730260 0.673 rs56236179 chr7:158843088 G/A cg02254261 chr7:158964346 NA -0.57 -6.31 -0.33 8.89e-10 Myopia (pathological); CRC cis rs7618915 0.508 rs11717043 chr3:52656092 A/T cg18404041 chr3:52824283 ITIH1 -0.43 -8.83 -0.44 6.25e-17 Bipolar disorder; CRC cis rs10504229 1.000 rs55944282 chr8:58180821 A/G cg24829409 chr8:58192753 C8orf71 -0.68 -11.34 -0.53 2.27e-25 Developmental language disorder (linguistic errors); CRC trans rs7819412 0.745 rs4841498 chr8:10985432 C/T cg16141378 chr3:129829833 LOC729375 0.44 6.43 0.33 4.55e-10 Triglycerides; CRC cis rs1448094 0.512 rs7302741 chr12:86237127 C/T cg00310523 chr12:86230176 RASSF9 0.35 5.87 0.31 1.07e-8 Major depressive disorder; CRC trans rs6956675 0.957 rs10236165 chr7:62596446 T/A cg01314568 chr7:57830625 NA -0.68 -9.32 -0.46 1.77e-18 Obesity-related traits; CRC cis rs4917300 0.626 rs902821 chr8:143100074 G/A cg25363559 chr8:143086065 NA -0.34 -6.36 -0.33 6.67e-10 Amyotrophic lateral sclerosis; CRC cis rs3806843 0.766 rs801176 chr5:140087010 A/G cg19875535 chr5:140030758 IK 0.53 8.58 0.43 3.69e-16 Depressive symptoms (multi-trait analysis); CRC cis rs9682041 0.696 rs13067560 chr3:170094190 G/A cg11886554 chr3:170076028 SKIL 0.69 8.29 0.42 3.01e-15 Glomerular filtration rate in non diabetics (creatinine);Glomerular filtration rate (creatinine); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg18350524 chr12:93835624 UBE2N 0.43 6.6 0.34 1.67e-10 Liver disease severity in Alagille syndrome; CRC cis rs56399783 0.614 rs55776032 chr7:2762255 T/C cg19731401 chr7:2775893 GNA12 0.72 7.56 0.38 4.08e-13 Childhood ear infection; CRC cis rs4588572 0.686 rs2362823 chr5:77693623 A/G cg11547950 chr5:77652471 NA 0.55 7.71 0.39 1.53e-13 Triglycerides; CRC cis rs17401966 0.894 rs12722830 chr1:10395134 A/G cg19773385 chr1:10388646 KIF1B -0.7 -11.41 -0.53 1.25e-25 Hepatocellular carcinoma; CRC cis rs9837602 0.938 rs9828079 chr3:99806645 A/G cg07805332 chr3:99536008 MIR548G;C3orf26 -0.47 -6.19 -0.32 1.74e-9 Breast cancer; CRC trans rs208520 0.837 rs208467 chr6:66914837 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.88 -11.77 -0.54 6.15e-27 Exhaled nitric oxide output; CRC cis rs7937682 0.632 rs14133 chr11:111782697 C/G cg09085632 chr11:111637200 PPP2R1B 0.96 15.35 0.65 1.69e-40 Primary sclerosing cholangitis; CRC cis rs10760158 0.832 rs10985192 chr9:124016440 G/T cg14417974 chr9:124058376 GSN -0.34 -5.7 -0.3 2.62e-8 Pulse pressure; CRC trans rs3807766 0.581 rs6954104 chr7:77693258 C/T cg01044731 chr13:24554006 NA -0.45 -6.16 -0.32 2.15e-9 3-hydroxypropylmercapturic acid levels in smokers; CRC cis rs2224391 1.000 rs2753247 chr6:5261987 A/T cg09085698 chr6:5261316 LYRM4;FARS2 -0.44 -5.71 -0.3 2.51e-8 Height; CRC cis rs2204008 0.774 rs11514062 chr12:38332297 A/C cg26384229 chr12:38710491 ALG10B 0.67 9.82 0.48 4e-20 Bladder cancer; CRC cis rs9522267 0.535 rs11069900 chr13:112233285 G/A cg26182253 chr13:112236782 NA 0.31 6.33 0.33 8.18e-10 Hepatitis; CRC cis rs9287719 0.967 rs6432116 chr2:10748615 T/C cg00105475 chr2:10696890 NA 0.45 7.17 0.37 4.87e-12 Prostate cancer; CRC cis rs7487075 0.820 rs2018424 chr12:46694657 C/T cg22049899 chr12:47219821 SLC38A4 0.31 5.92 0.31 8.32e-9 Itch intensity from mosquito bite; CRC cis rs9560113 1.000 rs4771757 chr13:112176379 G/T cg10483660 chr13:112241077 NA 0.36 5.75 0.3 2e-8 Menarche (age at onset); CRC cis rs4478858 0.735 rs11576603 chr1:31774031 C/T cg00250761 chr1:31883323 NA -0.38 -7.22 -0.37 3.68e-12 Alcohol dependence; CRC cis rs7617480 0.648 rs4974088 chr3:48898749 T/C cg20833759 chr3:49053208 WDR6;DALRD3 0.75 11.36 0.53 1.88e-25 Subjective well-being (multi-trait analysis);Menarche (age at onset); CRC trans rs17685 0.753 rs4728550 chr7:75670988 C/A cg19862616 chr7:65841803 NCRNA00174 -0.99 -18.5 -0.71 7.22e-53 Coffee consumption;Coffee consumption (cups per day); CRC cis rs11098499 0.789 rs1980024 chr4:120253047 C/T cg09307838 chr4:120376055 NA 0.61 9.59 0.47 2.22e-19 Corneal astigmatism; CRC cis rs28386778 0.897 rs4968598 chr17:61835579 T/C cg07362569 chr17:61921086 SMARCD2 0.37 5.73 0.3 2.27e-8 Prudent dietary pattern; CRC cis rs2658782 1.000 rs2658782 chr11:93166731 T/G cg15737290 chr11:93063684 CCDC67 0.5 7.25 0.37 3.02e-12 Pulmonary function decline; CRC cis rs6952808 1.000 rs6954521 chr7:1886865 C/A cg20295408 chr7:1910781 MAD1L1 -0.45 -6.25 -0.33 1.27e-9 Bipolar disorder and schizophrenia; CRC cis rs7208859 0.673 rs73265624 chr17:29232066 G/A cg14008862 chr17:28927542 LRRC37B2 0.55 5.75 0.3 2.04e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs10979 0.644 rs12527367 chr6:143918718 C/T cg25407410 chr6:143891975 LOC285740 -0.61 -8.36 -0.42 1.84e-15 Hypospadias; CRC cis rs11628318 0.614 rs1190342 chr14:103100382 C/T cg23071808 chr14:103021642 NA -0.64 -7.25 -0.37 2.99e-12 Platelet count; CRC cis rs7918232 0.882 rs10829190 chr10:27409555 C/T cg14442939 chr10:27389572 ANKRD26 0.78 8.84 0.44 6.02e-17 Breast cancer; CRC cis rs6123683 0.964 rs6127984 chr20:55824593 A/G cg13236649 chr20:55835020 BMP7 -0.41 -5.68 -0.3 3.04e-8 Facial morphology (factor 5, width of mouth relative to central midface); CRC trans rs17685 0.725 rs2302436 chr7:75676988 A/T cg19862616 chr7:65841803 NCRNA00174 -1.0 -18.5 -0.71 7.07e-53 Coffee consumption;Coffee consumption (cups per day); CRC cis rs1577917 0.917 rs2197651 chr6:86495442 G/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.61 -7.71 -0.39 1.46e-13 Response to antipsychotic treatment; CRC cis rs4629710 0.538 rs11754401 chr6:131582197 G/A cg12606694 chr6:131520996 AKAP7 0.57 8.4 0.42 1.39e-15 Multiple myeloma (IgH translocation); CRC cis rs10791323 0.627 rs2723614 chr11:133705871 T/G cg06766960 chr11:133703094 NA -0.37 -6.19 -0.32 1.82e-9 Childhood ear infection; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg00290498 chr5:1230850 SLC6A18 -0.37 -6.22 -0.32 1.51e-9 Liver disease severity in Alagille syndrome; CRC cis rs7901135 0.962 rs4948548 chr10:60570927 G/A cg06879152 chr10:60937041 PHYHIPL -0.37 -5.64 -0.3 3.61e-8 Morning vs. evening chronotype; CRC cis rs747650 0.892 rs1976142 chr11:47225694 T/C cg19486271 chr11:47235900 DDB2 -0.51 -7.71 -0.39 1.54e-13 Acne (severe); CRC cis rs514406 0.825 rs28817407 chr1:53226116 G/A cg27535305 chr1:53392650 SCP2 0.38 6.97 0.36 1.77e-11 Monocyte count; CRC cis rs3736485 0.966 rs10851500 chr15:51783820 T/C cg08986416 chr15:51914746 DMXL2 -0.44 -6.46 -0.34 3.7e-10 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs2991971 0.903 rs2991973 chr1:46020632 G/A cg24296786 chr1:45957014 TESK2 0.52 7.4 0.38 1.16e-12 High light scatter reticulocyte count; CRC cis rs17384381 1.000 rs12118950 chr1:85864519 T/C cg16011679 chr1:85725395 C1orf52 0.64 6.56 0.34 2.1e-10 Lobe attachment (rater-scored or self-reported); CRC cis rs2228479 0.702 rs11649501 chr16:89850957 A/T cg06558623 chr16:89946397 TCF25 1.12 10.46 0.5 2.76e-22 Skin colour saturation; CRC cis rs896854 0.654 rs28716845 chr8:95974485 A/G cg16049864 chr8:95962084 TP53INP1 -0.65 -11.81 -0.55 4.64e-27 Type 2 diabetes; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg06391894 chr10:72142531 LRRC20 0.46 6.11 0.32 2.77e-9 Anxiety disorder; CRC cis rs2836974 0.590 rs11911822 chr21:40607843 C/T cg11890956 chr21:40555474 PSMG1 -0.92 -16.17 -0.67 1.09e-43 Cognitive function; CRC cis rs524023 0.915 rs531763 chr11:64352063 A/G cg06522879 chr11:64358276 SLC22A12 0.56 8.75 0.43 1.16e-16 Urate levels in obese individuals; CRC cis rs853679 0.769 rs7752448 chr6:28301099 A/G cg15786705 chr6:28176104 NA 0.67 6.33 0.33 7.87e-10 Depression; CRC cis rs873946 0.586 rs2001426 chr10:134563871 G/A cg27286337 chr10:134555280 INPP5A 0.82 9.94 0.48 1.55e-20 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CRC cis rs1799949 0.965 rs6503726 chr17:41284742 T/C cg23758822 chr17:41437982 NA 0.91 17.65 0.7 1.59e-49 Menopause (age at onset); CRC cis rs904251 0.861 rs1776456 chr6:37484698 C/G cg01843034 chr6:37503916 NA -0.47 -8.75 -0.43 1.16e-16 Cognitive performance; CRC cis rs875971 0.862 rs6962717 chr7:65883735 G/A cg11764359 chr7:65958608 NA 0.59 9.08 0.45 1.06e-17 Aortic root size; CRC cis rs832540 0.656 rs2408597 chr5:56098632 G/A cg03609598 chr5:56110824 MAP3K1 -0.43 -5.88 -0.31 1.01e-8 Coronary artery disease; CRC cis rs3857536 0.605 rs36040831 chr6:66876588 G/A cg07460842 chr6:66804631 NA -0.68 -9.65 -0.47 1.46e-19 Blood trace element (Cu levels); CRC cis rs11214589 0.651 rs17600713 chr11:113259947 C/T cg14159747 chr11:113255604 NA 0.61 12.38 0.56 3.56e-29 Neuroticism; CRC cis rs4588572 0.643 rs13155648 chr5:77755343 A/G cg11547950 chr5:77652471 NA -0.52 -7.03 -0.36 1.16e-11 Triglycerides; CRC trans rs17685 0.712 rs10952842 chr7:75780413 G/A cg19862616 chr7:65841803 NCRNA00174 0.95 17.19 0.69 9.99e-48 Coffee consumption;Coffee consumption (cups per day); CRC cis rs10512697 0.803 rs34924743 chr5:3575736 A/G cg19473799 chr5:3511975 NA -0.72 -5.67 -0.3 3.12e-8 Immune response to smallpox vaccine (IL-6); CRC trans rs1814175 0.647 rs2903409 chr11:49953612 C/G cg11707556 chr5:10655725 ANKRD33B -0.37 -6.96 -0.36 1.8e-11 Height; CRC cis rs9894429 0.752 rs7502883 chr17:79588557 T/C cg18240062 chr17:79603768 NPLOC4 0.67 11.91 0.55 2.01e-27 Eye color traits; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg13057196 chr4:8442503 ACOX3 0.44 6.04 0.32 4.1e-9 Anxiety disorder; CRC cis rs6831352 0.851 rs1230164 chr4:99986023 C/G cg13256891 chr4:100009986 ADH5 0.62 8.17 0.41 6.8e-15 Alcohol dependence; CRC cis rs6540556 0.723 rs6679099 chr1:209895852 T/G cg05527609 chr1:210001259 C1orf107 -0.58 -6.3 -0.33 9.7e-10 Red blood cell count; CRC cis rs763121 0.815 rs9306328 chr22:39028913 C/T cg06544989 chr22:39130855 UNC84B 0.46 7.52 0.38 5.24e-13 Menopause (age at onset); CRC cis rs9287719 0.967 rs6432120 chr2:10753771 C/T cg00105475 chr2:10696890 NA 0.45 7.17 0.37 4.85e-12 Prostate cancer; CRC cis rs7258465 0.965 rs7253990 chr19:18604085 C/G cg06462663 chr19:18546047 ISYNA1 0.48 7.28 0.37 2.42e-12 Breast cancer; CRC cis rs7737355 0.947 rs32113 chr5:131049585 G/T cg06307176 chr5:131281290 NA -0.4 -5.78 -0.3 1.78e-8 Life satisfaction; CRC cis rs59043219 1 rs59043219 chr1:209970610 G/A cg12034118 chr1:209979487 IRF6 0.61 9.96 0.48 1.39e-20 Crohn's disease;Inflammatory bowel disease;Alzheimer's disease (APOE e4 interaction); CRC trans rs11098499 0.754 rs11724409 chr4:120252361 A/G cg25214090 chr10:38739885 LOC399744 0.53 8.36 0.42 1.81e-15 Corneal astigmatism; CRC cis rs9443189 0.570 rs7755068 chr6:76405700 A/G cg01950844 chr6:76311363 SENP6 0.74 9.84 0.48 3.35e-20 Prostate cancer; CRC cis rs2153535 0.601 rs9505473 chr6:8538777 T/C cg07606381 chr6:8435919 SLC35B3 0.69 11.24 0.53 5.16e-25 Motion sickness; CRC cis rs4563143 0.647 rs34218744 chr19:29256821 A/T cg12667521 chr19:29218732 NA 0.49 7.49 0.38 6.39e-13 Methadone dose in opioid dependence; CRC cis rs28386778 0.897 rs2727295 chr17:61887693 C/T cg11494091 chr17:61959527 GH2 0.52 8.79 0.44 8.27e-17 Prudent dietary pattern; CRC cis rs3850699 0.683 rs67646802 chr10:104303748 C/T cg11453585 chr10:104263688 ACTR1A;SUFU -0.44 -5.82 -0.31 1.43e-8 Prostate cancer; CRC cis rs2223471 0.875 rs2235497 chr6:50703074 G/A cg03432817 chr6:50765336 NA 0.41 6.54 0.34 2.33e-10 Subcutaneous adipose tissue; CRC cis rs1552244 0.882 rs35056669 chr3:10014171 C/T cg16606324 chr3:10149918 C3orf24 0.62 8.02 0.4 1.87e-14 Alzheimer's disease; CRC cis rs10971721 0.908 rs12376055 chr9:33831955 G/A cg13495928 chr9:33750294 PRSS3 0.55 5.93 0.31 7.7e-9 Body mass index; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg01021423 chr3:48541507 SHISA5 0.39 6.47 0.34 3.65e-10 Liver disease severity in Alagille syndrome; CRC cis rs1878931 0.624 rs1149492 chr16:3445239 A/G cg02880119 chr16:3481970 NA 0.42 5.84 0.31 1.24e-8 Body mass index (adult); CRC cis rs2439831 0.702 rs8033995 chr15:44013509 G/C cg02155558 chr15:43621948 ADAL;LCMT2 0.73 8.25 0.41 3.77e-15 Lung cancer in ever smokers; CRC cis rs801193 0.636 rs10233806 chr7:66118248 G/C cg11764359 chr7:65958608 NA -0.61 -9.5 -0.46 4.41e-19 Aortic root size; CRC cis rs7772486 0.659 rs9376957 chr6:146011064 C/T cg13319975 chr6:146136371 FBXO30 0.42 6.24 0.33 1.36e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs9420 0.961 rs10896647 chr11:57571883 C/T cg23127183 chr11:57508653 C11orf31 -0.53 -7.11 -0.36 7.49e-12 Schizophrenia; CRC trans rs1973993 0.544 rs2800427 chr1:97002766 A/C cg10631902 chr5:14652156 NA 0.5 9.2 0.45 4.34e-18 Weight; CRC cis rs9625935 0.518 rs245008 chr22:30315736 T/C cg01021169 chr22:30184971 ASCC2 -0.38 -5.9 -0.31 8.83e-9 Tonsillectomy; CRC cis rs10504229 0.683 rs7827014 chr8:58132230 G/A cg05313129 chr8:58192883 C8orf71 -0.43 -6.11 -0.32 2.74e-9 Developmental language disorder (linguistic errors); CRC cis rs13191362 0.935 rs66962088 chr6:162963891 C/T cg23758597 chr6:163146217 PARK2 -0.55 -5.62 -0.3 4.13e-8 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs2878628 0.650 rs56098033 chr3:52758571 T/A cg11645453 chr3:52864694 ITIH4 0.37 6.55 0.34 2.23e-10 Intelligence (multi-trait analysis); CRC cis rs751728 1.000 rs4713682 chr6:33757047 G/C cg25922239 chr6:33757077 LEMD2 0.64 9.94 0.48 1.58e-20 Crohn's disease; CRC cis rs1552244 1.000 rs55822690 chr3:10128003 A/G cg13047869 chr3:10149882 C3orf24 0.56 7.63 0.39 2.59e-13 Alzheimer's disease; CRC cis rs2576037 0.583 rs646128 chr18:44397691 A/C cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.62 10.48 0.5 2.21e-22 Personality dimensions; CRC cis rs1577917 1.000 rs34281561 chr6:86701872 T/A cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.53 -6.64 -0.34 1.32e-10 Response to antipsychotic treatment; CRC cis rs10504229 0.639 rs35527749 chr8:58128077 G/T cg21724239 chr8:58056113 NA 0.76 9.41 0.46 8.87e-19 Developmental language disorder (linguistic errors); CRC trans rs7613875 0.600 rs2247510 chr3:50126215 A/C cg21665057 chr3:196295764 WDR53;FBXO45 0.49 7.24 0.37 3.23e-12 Body mass index; CRC cis rs6456156 0.774 rs1012657 chr6:167525142 A/C cg05540913 chr6:167530185 CCR6 -0.35 -6.07 -0.32 3.5e-9 Primary biliary cholangitis; CRC cis rs16924133 1.000 rs12286381 chr11:33224160 C/T cg05567920 chr11:33183001 CSTF3 -0.78 -6.08 -0.32 3.39e-9 Anger; CRC trans rs637571 0.528 rs11602769 chr11:65594139 T/C cg17712092 chr4:129076599 LARP1B -0.61 -9.31 -0.46 1.9e-18 Eosinophil percentage of white cells; CRC cis rs9522267 0.535 rs9515453 chr13:112234612 T/C cg10483660 chr13:112241077 NA -0.48 -8.99 -0.44 2.04e-17 Hepatitis; CRC cis rs9747201 0.925 rs8072670 chr17:80159566 T/C cg09264619 chr17:80180166 NA -0.49 -7.13 -0.37 6.39e-12 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs2836974 0.897 rs2836924 chr21:40525639 C/T cg11644478 chr21:40555479 PSMG1 0.82 13.39 0.59 6.26e-33 Cognitive function; CRC cis rs12477438 0.798 rs9808541 chr2:99642179 A/T cg14399236 chr2:99771627 LIPT1;TSGA10 -0.74 -10.4 -0.5 4.36e-22 Chronic sinus infection; CRC trans rs7647973 0.626 rs62260723 chr3:49872124 T/C cg21659725 chr3:3221576 CRBN 0.66 7.32 0.37 1.94e-12 Menarche (age at onset); CRC cis rs3857536 0.813 rs6903411 chr6:66938288 T/C cg07460842 chr6:66804631 NA -0.43 -5.81 -0.3 1.48e-8 Blood trace element (Cu levels); CRC cis rs6964587 1.000 rs12704635 chr7:91737324 T/G cg17063962 chr7:91808500 NA 0.81 14.06 0.61 1.72e-35 Breast cancer; CRC cis rs6912958 0.781 rs9444524 chr6:88311260 T/C cg08069147 chr6:88032118 GJB7;C6orf162 -0.57 -8.59 -0.43 3.63e-16 Monocyte percentage of white cells; CRC cis rs8031584 0.958 rs35256769 chr15:31237776 G/A cg14829155 chr15:31115871 NA -0.48 -7.8 -0.4 8.13e-14 Huntington's disease progression; CRC cis rs8060686 0.858 rs7206671 chr16:67807146 A/G cg07125278 chr16:67683757 RLTPR -0.47 -6.16 -0.32 2.1e-9 HDL cholesterol;Metabolic syndrome; CRC cis rs10924970 1.000 rs7339903 chr1:235337733 C/T cg26050004 chr1:235667680 B3GALNT2 0.4 5.85 0.31 1.21e-8 Asthma; CRC cis rs9381040 0.655 rs879491 chr6:41026953 A/G cg09580153 chr6:41068724 NFYA;LOC221442 -0.43 -6.28 -0.33 1.1e-9 Alzheimer's disease (late onset); CRC trans rs7873102 0.702 rs7028020 chr9:38007747 C/T cg15947007 chr7:64023509 ZNF680 -0.42 -6.37 -0.33 6.33e-10 Brain structure; CRC cis rs7607369 0.648 rs7582193 chr2:219652532 T/C cg02176678 chr2:219576539 TTLL4 -0.56 -9.02 -0.45 1.59e-17 Red blood cell count;Amyotrophic lateral sclerosis; CRC cis rs4713118 0.615 rs9348772 chr6:27656090 G/T cg25164649 chr6:28176230 NA 0.44 6.24 0.33 1.32e-9 Parkinson's disease; CRC cis rs3806843 0.657 rs2563283 chr5:140105978 C/A cg26395211 chr5:140044315 WDR55 0.38 5.68 0.3 2.99e-8 Depressive symptoms (multi-trait analysis); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg23704689 chr12:110906840 GPN3;C12orf24 0.39 6.23 0.32 1.41e-9 Liver disease severity in Alagille syndrome; CRC cis rs3771570 1.000 rs62193175 chr2:242284405 G/A cg21155796 chr2:242212141 HDLBP 0.64 6.98 0.36 1.63e-11 Prostate cancer; CRC cis rs910316 1.000 rs1047418 chr14:75605792 A/G cg08847533 chr14:75593920 NEK9 0.93 17.49 0.69 6.64e-49 Height; CRC cis rs9921222 0.585 rs7195617 chr16:376781 A/G cg26944245 chr16:421049 TMEM8A;MRPL28 -0.46 -6.95 -0.36 1.97e-11 Bone mineral density (spine);Bone mineral density; CRC cis rs4073582 1.000 rs801732 chr11:65935502 T/A cg16950941 chr11:66035639 RAB1B 0.66 9.56 0.47 2.92e-19 Gout; CRC cis rs10504229 0.906 rs58251024 chr8:58172259 G/C cg02725872 chr8:58115012 NA -0.38 -6.43 -0.33 4.44e-10 Developmental language disorder (linguistic errors); CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg07498606 chr16:67313043 PLEKHG4 0.45 6.08 0.32 3.29e-9 Anxiety disorder; CRC cis rs554111 0.634 rs4654875 chr1:21165176 A/G cg02927042 chr1:21476669 EIF4G3 0.38 5.71 0.3 2.58e-8 Facial morphology (factor 17, height of vermillion upper lip); CRC cis rs13315871 1.000 rs9869940 chr3:58401523 G/A cg20936604 chr3:58311152 NA -0.75 -7.12 -0.37 6.99e-12 Cholesterol, total; CRC cis rs35883536 0.647 rs2783703 chr1:101040794 T/C cg06223162 chr1:101003688 GPR88 0.34 6.32 0.33 8.46e-10 Monocyte count; CRC cis rs7412746 0.658 rs2230061 chr1:150727539 G/A cg18016565 chr1:150552671 MCL1 0.44 6.02 0.31 4.71e-9 Melanoma; CRC cis rs4474465 0.688 rs7940507 chr11:78284453 T/C cg27205649 chr11:78285834 NARS2 0.54 7.08 0.36 9.03e-12 Alzheimer's disease (survival time); CRC cis rs8060686 0.841 rs56374641 chr16:67908713 G/T cg07125278 chr16:67683757 RLTPR -0.63 -7.26 -0.37 2.85e-12 HDL cholesterol;Metabolic syndrome; CRC cis rs11711311 0.747 rs11928494 chr3:113343219 T/C cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.54 -7.17 -0.37 4.96e-12 IgG glycosylation; CRC cis rs9399137 0.507 rs11759062 chr6:135381248 A/C cg24558204 chr6:135376177 HBS1L 0.6 8.93 0.44 3.13e-17 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; CRC cis rs6988985 0.728 rs10093618 chr8:143952214 A/G cg10324643 chr8:143916377 GML -0.35 -5.9 -0.31 9.16e-9 Plasma androstenedione levels in resected early stage-receptor positive breast cancer; CRC cis rs904251 0.766 rs1757175 chr6:37486694 T/C cg25019722 chr6:37503610 NA -0.5 -9.29 -0.46 2.17e-18 Cognitive performance; CRC trans rs7615952 0.512 rs34651730 chr3:125358640 T/C cg02560186 chr11:3602584 NA -0.63 -9.54 -0.47 3.23e-19 Blood pressure (smoking interaction); CRC cis rs11212617 0.967 rs227062 chr11:108205383 G/A cg14761454 chr11:108092087 ATM;NPAT 0.43 6.54 0.34 2.39e-10 Response to metformin in type 2 diabetes (glycemic); CRC cis rs4731207 0.596 rs7799771 chr7:124649937 C/A cg23710748 chr7:124431027 NA -0.39 -6.25 -0.33 1.24e-9 Cutaneous malignant melanoma; CRC cis rs12594515 0.600 rs12903858 chr15:45972166 A/G cg22117107 chr15:45993392 NA -0.39 -7.77 -0.39 9.97e-14 Waist circumference;Weight; CRC cis rs728616 0.867 rs723191 chr10:81707920 A/G cg11900509 chr10:81946545 ANXA11 -0.65 -6.6 -0.34 1.68e-10 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs12950390 0.853 rs12450729 chr17:45855363 A/G cg24803719 chr17:45855879 NA -0.32 -7.02 -0.36 1.24e-11 IgG glycosylation; CRC cis rs5769765 0.773 rs9616208 chr22:50313359 G/A cg22709217 chr22:50311962 ALG12;CRELD2 -1.11 -18.27 -0.71 5.53e-52 Schizophrenia; CRC cis rs9287719 0.967 rs6744854 chr2:10747246 C/G cg00105475 chr2:10696890 NA 0.45 7.15 0.37 5.48e-12 Prostate cancer; CRC cis rs7223966 1.000 rs8067064 chr17:61825984 A/C cg23090583 chr17:61904693 PSMC5;FTSJ3 0.5 6.17 0.32 2.02e-9 Hip circumference adjusted for BMI;Body mass index; CRC cis rs1799949 1.000 rs8077486 chr17:41212805 C/T cg19454999 chr17:41278357 BRCA1;NBR2 0.41 6.33 0.33 8.2e-10 Menopause (age at onset); CRC cis rs3849570 0.695 rs62265411 chr3:81573660 T/C cg07356753 chr3:81810745 GBE1 -0.53 -6.91 -0.36 2.51e-11 Waist circumference;Body mass index; CRC cis rs4713118 0.824 rs9468229 chr6:27750086 G/A cg15845792 chr6:28175446 NA 0.68 8.92 0.44 3.35e-17 Parkinson's disease; CRC cis rs243505 0.559 rs10215794 chr7:148478895 C/G cg09806900 chr7:148480153 CUL1 0.62 8.72 0.43 1.35e-16 Inflammatory bowel disease;Crohn's disease; CRC cis rs8180040 0.739 rs4683320 chr3:47152992 C/T cg27129171 chr3:47204927 SETD2 0.76 13.04 0.58 1.31e-31 Colorectal cancer; CRC cis rs10791323 0.581 rs2723608 chr11:133710149 A/G cg00579200 chr11:133705235 NA -0.4 -5.92 -0.31 8.18e-9 Childhood ear infection; CRC cis rs5750830 0.594 rs6001587 chr22:39819008 T/C cg25956985 chr22:39795188 MAP3K7IP1 -0.46 -6.5 -0.34 2.96e-10 Intelligence (multi-trait analysis); CRC cis rs9362426 0.708 rs9342112 chr6:88092491 A/G cg08069147 chr6:88032118 GJB7;C6orf162 0.47 6.26 0.33 1.23e-9 Depressive episodes in bipolar disorder; CRC cis rs754466 0.606 rs11002315 chr10:79617385 T/G cg17075019 chr10:79541650 NA -0.89 -15.36 -0.65 1.55e-40 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs3733585 0.699 rs6449172 chr4:9966036 A/T cg11266682 chr4:10021025 SLC2A9 -0.47 -9.53 -0.46 3.68e-19 Cleft plate (environmental tobacco smoke interaction); CRC cis rs2243480 1.000 rs35432774 chr7:65393019 G/C cg18252515 chr7:66147081 NA -1.08 -12.63 -0.57 4.33e-30 Diabetic kidney disease; CRC cis rs7493 1.000 rs2286232 chr7:95039445 C/T cg19678392 chr7:94953810 PON1 -0.57 -7.2 -0.37 4.21e-12 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs9372498 0.572 rs62422230 chr6:118959436 T/C cg22561889 chr6:118971681 C6orf204 0.48 5.92 0.31 8.26e-9 Diastolic blood pressure; CRC cis rs910316 0.934 rs4903278 chr14:75535019 C/A cg03030879 chr14:75389066 RPS6KL1 -0.45 -7.06 -0.36 9.86e-12 Height; CRC cis rs10791323 0.582 rs2723613 chr11:133706696 G/A cg15485101 chr11:133734466 NA 0.4 6.73 0.35 7.36e-11 Childhood ear infection; CRC cis rs9297145 0.565 rs941001 chr7:98735185 A/T cg05967295 chr7:98741636 SMURF1 -0.61 -9.61 -0.47 1.99e-19 Crohn's disease;Inflammatory bowel disease;Ulcerative colitis; CRC cis rs7703744 0.634 rs6884061 chr5:118683431 C/T cg19893178 chr5:118692011 TNFAIP8 0.42 5.66 0.3 3.3e-8 Lobe attachment (rater-scored or self-reported); CRC cis rs10540 0.730 rs12789735 chr11:518509 G/A cg03352830 chr11:487213 PTDSS2 0.65 7.4 0.38 1.15e-12 Body mass index; CRC cis rs7647973 0.710 rs2029591 chr3:49646981 C/T cg03060546 chr3:49711283 APEH -0.66 -7.82 -0.4 7.38e-14 Menarche (age at onset); CRC cis rs968567 0.539 rs174555 chr11:61579760 T/C cg00603274 chr11:61596626 FADS2 -0.49 -6.92 -0.36 2.42e-11 Blood metabolite levels;Rheumatoid arthritis;Vitiligo;Glycerophospholipid levels; CRC cis rs3736485 0.578 rs4775968 chr15:51980821 A/G cg08986416 chr15:51914746 DMXL2 0.39 5.75 0.3 2.03e-8 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs4713118 0.869 rs9283883 chr6:27715470 T/A cg12172441 chr6:28176163 NA 0.55 7.55 0.38 4.33e-13 Parkinson's disease; CRC cis rs7715806 0.500 rs17563610 chr5:74981322 A/T cg00601450 chr5:74908170 NA 0.49 6.18 0.32 1.88e-9 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs9487051 0.676 rs7775206 chr6:109597222 A/G cg12927641 chr6:109611667 NA -0.38 -6.74 -0.35 7.22e-11 Reticulocyte fraction of red cells; CRC cis rs35146811 0.660 rs3779046 chr7:99779243 A/G cg13334819 chr7:99746414 C7orf59 -0.51 -6.72 -0.35 7.79e-11 Coronary artery disease; CRC cis rs875971 1.000 rs811880 chr7:65818646 T/C cg00343986 chr7:65444356 GUSB 0.43 6.37 0.33 6.49e-10 Aortic root size; CRC cis rs1862618 0.853 rs10461617 chr5:56104308 A/G cg12311346 chr5:56204834 C5orf35 -0.81 -10.7 -0.51 4.11e-23 Initial pursuit acceleration; CRC cis rs863345 0.604 rs6666609 chr1:158498124 G/A cg12129480 chr1:158549410 OR10X1 -0.3 -6.27 -0.33 1.12e-9 Pneumococcal bacteremia; CRC cis rs765787 0.530 rs11858988 chr15:45522114 T/C cg24006582 chr15:45444508 DUOX1 -0.56 -8.55 -0.43 4.67e-16 Uric acid levels; CRC cis rs10504229 0.728 rs72650868 chr8:58155568 G/C cg02725872 chr8:58115012 NA -0.57 -9.07 -0.45 1.09e-17 Developmental language disorder (linguistic errors); CRC cis rs4888262 0.564 rs8062404 chr16:74611675 T/C cg01733217 chr16:74700730 RFWD3 0.79 11.94 0.55 1.53e-27 Testicular germ cell tumor; CRC cis rs10751667 0.643 rs10794350 chr11:946070 A/G cg23136738 chr11:925521 AP2A2 -0.4 -6.65 -0.34 1.21e-10 Alzheimer's disease (late onset); CRC cis rs1538970 0.962 rs9429072 chr1:45810091 C/T cg05343316 chr1:45956843 TESK2 -0.64 -8.97 -0.44 2.38e-17 Platelet count; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg12427896 chr2:111880694 BCL2L11 0.42 6.04 0.32 4.15e-9 Response to antipsychotic treatment; CRC trans rs925098 0.577 rs2724470 chr4:17996046 A/G cg16339185 chr3:20227809 SGOL1 -0.45 -6.34 -0.33 7.52e-10 Birth weight;Height; CRC cis rs4713118 0.869 rs9468214 chr6:27713299 G/C cg15845792 chr6:28175446 NA 0.66 9.05 0.45 1.3e-17 Parkinson's disease; CRC cis rs1552244 1.000 rs12152515 chr3:10143976 C/T cg16606324 chr3:10149918 C3orf24 0.68 9.69 0.47 1.07e-19 Alzheimer's disease; CRC cis rs9547692 1.000 rs9531991 chr13:37470945 A/G cg01493522 chr13:37497338 NA -0.55 -7.51 -0.38 5.51e-13 Coronary artery disease; CRC trans rs3942852 0.712 rs2174129 chr11:48108557 A/C cg15704280 chr7:45808275 SEPT13 -0.63 -8.0 -0.4 2.22e-14 Acute lymphoblastic leukemia (childhood); CRC cis rs7249142 0.562 rs10417796 chr19:19287072 A/G cg26504305 chr19:19281019 LOC729991-MEF2B;MEF2B -0.43 -8.87 -0.44 4.85e-17 IgG glycosylation; CRC trans rs7819412 0.521 rs10100660 chr8:11038885 T/A cg06636001 chr8:8085503 FLJ10661 -0.45 -6.53 -0.34 2.49e-10 Triglycerides; CRC trans rs7937682 0.924 rs10891284 chr11:111527737 T/C cg18187862 chr3:45730750 SACM1L 0.47 6.82 0.35 4.38e-11 Primary sclerosing cholangitis; CRC cis rs823143 0.570 rs823082 chr1:205786935 C/T cg07157834 chr1:205819609 PM20D1 -0.6 -9.2 -0.45 4.24e-18 Monocyte percentage of white cells; CRC cis rs3126085 0.515 rs7514696 chr1:152363874 G/A cg09127314 chr1:152161683 NA -0.44 -5.84 -0.31 1.25e-8 Atopic dermatitis; CRC cis rs172166 0.769 rs149965 chr6:28018689 T/A cg15845792 chr6:28175446 NA 0.77 11.37 0.53 1.73e-25 Cardiac Troponin-T levels; CRC cis rs727505 0.954 rs1014163 chr7:124443604 G/A cg23710748 chr7:124431027 NA -0.82 -14.47 -0.62 4.41e-37 Lewy body disease; CRC trans rs9914544 0.545 rs7222893 chr17:18811702 A/G cg21372672 chr17:16614065 CCDC144A -0.4 -6.33 -0.33 8.06e-10 Educational attainment (years of education); CRC cis rs9611565 0.643 rs202634 chr22:41809623 A/G cg06481639 chr22:41940642 POLR3H 0.52 5.92 0.31 8.32e-9 Vitiligo; CRC cis rs752010 0.714 rs7513753 chr1:42079232 A/G cg06885757 chr1:42089581 HIVEP3 0.47 8.42 0.42 1.16e-15 Lupus nephritis in systemic lupus erythematosus; CRC cis rs11148252 0.553 rs7999849 chr13:53249414 A/G cg00495681 chr13:53174319 NA 0.84 15.51 0.65 4.07e-41 Lewy body disease; CRC trans rs10982213 0.830 rs2274163 chr9:117188714 C/T cg24542852 chr12:569111 B4GALNT3 0.4 6.32 0.33 8.46e-10 Interleukin-6 levels; CRC cis rs1005277 0.579 rs2474563 chr10:38375938 T/C cg25427524 chr10:38739819 LOC399744 -0.76 -13.53 -0.6 1.8e-33 Extrinsic epigenetic age acceleration; CRC cis rs8177253 0.665 rs6774822 chr3:133442012 G/T cg16262614 chr3:133464971 TF 0.35 6.15 0.32 2.26e-9 Iron status biomarkers; CRC cis rs4319547 0.695 rs4758666 chr12:122902840 C/T cg23029597 chr12:123009494 RSRC2 -0.53 -6.83 -0.35 4.1e-11 Body mass index; CRC trans rs6703335 0.870 rs10803142 chr1:243598234 A/G cg09564133 chr5:176738847 MXD3 0.42 5.97 0.31 6.03e-9 Schizophrenia;Schizophrenia, schizoaffective disorder or bipolar disorder; CRC cis rs294883 0.739 rs9457588 chr6:159732999 G/T cg14500486 chr6:159655392 FNDC1 -0.35 -5.95 -0.31 6.68e-9 Coronary artery disease; CRC cis rs9611565 0.694 rs202618 chr22:41822856 A/G cg06634786 chr22:41940651 POLR3H 0.7 7.77 0.39 1.02e-13 Vitiligo; CRC cis rs7666738 0.791 rs2865953 chr4:99040319 C/T cg17366294 chr4:99064904 C4orf37 0.44 7.45 0.38 8.17e-13 Colonoscopy-negative controls vs population controls; CRC cis rs28386778 0.830 rs2597636 chr17:61876010 A/G cg11494091 chr17:61959527 GH2 0.62 10.57 0.5 1.13e-22 Prudent dietary pattern; CRC cis rs6088580 0.634 rs6142159 chr20:32993035 G/A cg24642439 chr20:33292090 TP53INP2 -0.38 -6.39 -0.33 5.8e-10 Glomerular filtration rate (creatinine); CRC cis rs11711311 1.000 rs13073843 chr3:113449150 A/G cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.52 -7.0 -0.36 1.47e-11 IgG glycosylation; CRC cis rs2836633 0.895 rs2836598 chr21:40024758 C/G cg05519781 chr21:40033154 ERG 0.67 13.46 0.6 3.36e-33 Coronary artery disease; CRC trans rs2303319 0.504 rs62189055 chr2:162625749 C/A cg09481857 chr22:21368659 P2RX6;MGC16703 -0.65 -6.34 -0.33 7.73e-10 Cognitive function; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg16420247 chr2:10442859 HPCAL1 -0.4 -6.38 -0.33 5.89e-10 Myopia (pathological); CRC cis rs7095944 0.582 rs2303611 chr10:126517989 G/A cg08799069 chr10:126477246 METTL10 -0.46 -7.16 -0.37 5.46e-12 Asthma; CRC cis rs9640161 0.789 rs28439010 chr7:150046276 C/T cg27494647 chr7:150038898 RARRES2 0.36 5.65 0.3 3.47e-8 Blood protein levels;Circulating chemerin levels; CRC cis rs9443645 0.687 rs6915558 chr6:79769056 A/T cg11833968 chr6:79620685 NA -0.37 -6.35 -0.33 7.05e-10 Intelligence (multi-trait analysis); CRC cis rs769267 0.965 rs4808938 chr19:19401218 G/A cg02546618 chr19:19431379 KIAA0892;SF4 0.46 6.35 0.33 7.02e-10 Tonsillectomy; CRC cis rs10256972 0.621 rs2280725 chr7:1087426 G/T cg04025307 chr7:1156635 C7orf50 0.46 6.94 0.36 2.03e-11 Longevity;Endometriosis; CRC cis rs1129187 0.818 rs9462858 chr6:42946490 C/A cg21280719 chr6:42927975 GNMT -0.43 -9.12 -0.45 7.46e-18 Alzheimer's disease in APOE e4+ carriers; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg03821916 chr17:58755215 BCAS3 0.4 6.25 0.33 1.27e-9 Liver disease severity in Alagille syndrome; CRC cis rs6840360 0.533 rs4696295 chr4:152717430 T/C cg09659197 chr4:152720779 NA -0.44 -8.72 -0.43 1.36e-16 Intelligence (multi-trait analysis); CRC cis rs2038227 1 rs2038227 chr16:539140 C/A cg06259664 chr16:537672 RAB11FIP3 0.8 14.18 0.62 6.16e-36 Venous thromboembolism (SNP x SNP interaction); CRC cis rs2180341 0.960 rs7753913 chr6:127671296 A/G cg27446573 chr6:127587934 RNF146 0.97 13.77 0.6 2.17e-34 Breast cancer; CRC cis rs10760158 0.832 rs4837827 chr9:124039871 C/T cg14417974 chr9:124058376 GSN -0.36 -6.08 -0.32 3.39e-9 Pulse pressure; CRC trans rs1814175 0.645 rs6486022 chr11:49776137 A/G cg15704280 chr7:45808275 SEPT13 -0.96 -17.2 -0.69 9.1e-48 Height; CRC trans rs7267979 1.000 rs6083825 chr20:25366424 T/C cg17903999 chr18:56338584 MALT1 0.42 6.98 0.36 1.63e-11 Liver enzyme levels (alkaline phosphatase); CRC cis rs9649213 0.593 rs7778015 chr7:97920270 T/C cg00277769 chr7:97922759 BAIAP2L1 -0.61 -10.79 -0.51 1.87e-23 Prostate cancer (SNP x SNP interaction); CRC cis rs9916302 0.706 rs7212621 chr17:37527911 T/G cg07936489 chr17:37558343 FBXL20 0.93 11.81 0.55 4.37e-27 Glomerular filtration rate (creatinine); CRC cis rs6860806 0.507 rs272892 chr5:131664349 C/T cg09877947 chr5:131593287 PDLIM4 0.43 7.09 0.36 8.22e-12 Breast cancer; CRC cis rs7666738 0.830 rs13138051 chr4:99050367 C/T cg17366294 chr4:99064904 C4orf37 0.45 7.75 0.39 1.16e-13 Colonoscopy-negative controls vs population controls; CRC cis rs10128264 0.902 rs1250588 chr10:80980169 T/C cg18737081 chr10:80999807 ZMIZ1 -0.37 -6.52 -0.34 2.67e-10 Response to methotrexate in juvenile idiopathic arthritis; CRC cis rs6582630 0.638 rs7963994 chr12:38555535 G/A cg26384229 chr12:38710491 ALG10B -0.52 -7.61 -0.39 2.82e-13 Drug-induced liver injury (flucloxacillin); CRC cis rs477895 0.713 rs67546972 chr11:63962162 G/A cg19465662 chr11:63993652 NUDT22;TRPT1 0.73 8.97 0.44 2.31e-17 Mean platelet volume; CRC cis rs9858542 1.000 rs6770670 chr3:49686682 T/C cg00383909 chr3:49044727 WDR6 0.47 5.89 0.31 9.58e-9 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs4862750 0.957 rs1030381 chr4:187903568 G/C cg06074448 chr4:187884817 NA -0.62 -11.21 -0.53 6.25e-25 Lobe attachment (rater-scored or self-reported); CRC cis rs853679 0.517 rs9393896 chr6:28127703 C/T cg12273811 chr6:28175739 NA 0.73 9.16 0.45 5.8e-18 Depression; CRC cis rs4700695 0.841 rs706679 chr5:65317181 A/G cg21114390 chr5:65439923 SFRS12 -0.55 -6.63 -0.34 1.36e-10 Facial morphology (factor 19); CRC cis rs7312774 0.618 rs73385161 chr12:107300164 G/A cg16260113 chr12:107380972 MTERFD3 0.78 7.76 0.39 1.11e-13 Severe influenza A (H1N1) infection; CRC trans rs60843830 1.000 rs10193373 chr2:281886 T/G cg11347411 chr7:150020925 ACTR3C;LRRC61 0.61 9.55 0.47 3.15e-19 Spherical equivalent (joint analysis main effects and education interaction); CRC cis rs7789940 0.904 rs12531348 chr7:75937191 G/C cg10167463 chr7:75959203 YWHAG -0.68 -8.93 -0.44 3.1e-17 Multiple sclerosis; CRC trans rs2727020 0.755 rs652655 chr11:49251293 G/A cg21153622 chr11:89784906 NA 0.44 7.12 0.37 7.02e-12 Coronary artery disease; CRC cis rs736408 0.609 rs2268025 chr3:52795224 A/T cg08222913 chr3:52553049 STAB1 -0.34 -6.13 -0.32 2.49e-9 Bipolar disorder; CRC cis rs3806843 0.966 rs2337986 chr5:140160622 C/T cg16607685 chr5:140181889 PCDHA2;PCDHA1;PCDHA3 -0.26 -5.92 -0.31 8.06e-9 Depressive symptoms (multi-trait analysis); CRC cis rs9399135 0.967 rs4896119 chr6:135293391 C/T cg24558204 chr6:135376177 HBS1L 0.5 7.85 0.4 5.9e-14 Red blood cell count; CRC cis rs4555082 0.834 rs2816653 chr14:105713973 A/G cg18132624 chr14:105716052 BTBD6;BRF1 -0.49 -8.07 -0.41 1.34e-14 Mean platelet volume;Platelet distribution width; CRC cis rs10504229 0.769 rs17804383 chr8:58151830 A/G cg22535103 chr8:58192502 C8orf71 -0.68 -8.37 -0.42 1.72e-15 Developmental language disorder (linguistic errors); CRC cis rs754466 0.651 rs7895188 chr10:79623378 C/G cg17075019 chr10:79541650 NA 0.89 15.48 0.65 5.48e-41 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs11098499 1.000 rs58601355 chr4:120186367 T/C cg09307838 chr4:120376055 NA 0.64 9.78 0.47 5.38e-20 Corneal astigmatism; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg13535441 chr11:73882018 C2CD3;PPME1 0.44 5.98 0.31 5.82e-9 Anxiety disorder; CRC trans rs2797160 1.000 rs1739354 chr6:126017808 G/C cg05039488 chr6:79577232 IRAK1BP1 0.51 7.6 0.39 3.19e-13 Endometrial cancer; CRC cis rs2979489 0.891 rs2915591 chr8:30395948 C/G cg26383811 chr8:30366931 RBPMS -0.68 -9.79 -0.47 5.01e-20 Mean corpuscular hemoglobin;Plateletcrit;Neutrophil count;Granulocyte count;Sum basophil neutrophil counts;Mean corpuscular volume;Myeloid white cell count;Sum neutrophil eosinophil counts; CRC cis rs1799949 1.000 rs4793231 chr17:41427469 A/G cg25072359 chr17:41440525 NA 0.41 6.02 0.32 4.64e-9 Menopause (age at onset); CRC cis rs2797160 1.000 rs2797154 chr6:126005197 A/G cg05901451 chr6:126070800 HEY2 -0.4 -6.18 -0.32 1.93e-9 Endometrial cancer; CRC trans rs12699683 0.522 rs917796 chr7:15124846 C/T cg24762932 chr10:23460245 NA 0.58 6.24 0.33 1.34e-9 Paclitaxel-induced neuropathy; CRC cis rs4285028 0.898 rs73855476 chr3:121633412 A/G cg11130432 chr3:121712080 ILDR1 -0.46 -5.87 -0.31 1.05e-8 Multiple sclerosis; CRC cis rs13064411 0.696 rs7622740 chr3:113206771 G/A cg18753928 chr3:113234510 CCDC52 -0.69 -10.55 -0.5 1.27e-22 Response to simvastatin treatment (PCSK9 protein level change); CRC cis rs6570726 0.791 rs398408 chr6:145801020 G/A cg05347473 chr6:146136440 FBXO30 0.38 5.85 0.31 1.19e-8 Lobe attachment (rater-scored or self-reported); CRC cis rs8062405 0.558 rs151228 chr16:28563026 A/G cg05139728 chr16:28306816 SBK1 -0.33 -5.82 -0.31 1.42e-8 Cognitive ability (multi-trait analysis);Cognitive ability; CRC cis rs7811142 1.000 rs67239991 chr7:100046504 A/G cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.62 8.34 0.42 2.01e-15 Platelet count; CRC cis rs8060686 0.641 rs75450962 chr16:68210868 C/T cg26727032 chr16:67993705 SLC12A4 -0.53 -6.24 -0.33 1.37e-9 HDL cholesterol;Metabolic syndrome; CRC cis rs6951245 1.000 rs118059236 chr7:1073202 A/C cg22907277 chr7:1156413 C7orf50 0.71 7.39 0.38 1.26e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs4665809 0.590 rs72809668 chr2:26467653 C/T cg22920501 chr2:26401640 FAM59B 0.83 11.96 0.55 1.28e-27 Gut microbiome composition (summer); CRC cis rs3733585 0.648 rs67820465 chr4:9975873 A/G cg11266682 chr4:10021025 SLC2A9 -0.47 -9.55 -0.47 3e-19 Cleft plate (environmental tobacco smoke interaction); CRC cis rs9811920 0.609 rs793501 chr3:99591638 T/C cg07805332 chr3:99536008 MIR548G;C3orf26 -0.51 -7.65 -0.39 2.21e-13 Axial length; CRC cis rs7072216 0.763 rs2274245 chr10:100175082 C/T cg26618903 chr10:100175079 PYROXD2 -0.55 -8.99 -0.44 2.03e-17 Metabolite levels; CRC cis rs1707322 0.752 rs28545085 chr1:46201950 G/A cg03146154 chr1:46216737 IPP 0.68 9.85 0.48 3.13e-20 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs2739330 0.791 rs4822458 chr22:24265659 C/T cg16132339 chr22:24313637 DDTL;DDT 0.67 11.33 0.53 2.38e-25 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs6499255 1.000 rs60231938 chr16:69830415 G/A cg15192750 chr16:69999425 NA 0.56 7.31 0.37 2.02e-12 IgE levels; CRC cis rs2742417 0.603 rs2673075 chr3:45778288 C/A cg04837898 chr3:45731254 SACM1L -0.47 -7.59 -0.39 3.26e-13 Response to anti-depressant treatment in major depressive disorder; CRC cis rs11161851 0.550 rs11162359 chr1:75461044 G/A cg11196437 chr1:75593865 LHX8 0.27 5.63 0.3 3.96e-8 Visceral fat; CRC cis rs73200209 0.912 rs17498648 chr12:116610902 C/G cg01776926 chr12:116560359 MED13L -0.48 -5.94 -0.31 7.34e-9 Total body bone mineral density; CRC cis rs11098499 0.754 rs714899 chr4:120243035 G/A cg24375607 chr4:120327624 NA 0.48 7.72 0.39 1.45e-13 Corneal astigmatism; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg03545677 chr2:47403996 CALM2 0.5 7.12 0.37 6.84e-12 Response to antipsychotic treatment; CRC cis rs1707322 0.716 rs10890342 chr1:46157087 C/T cg06784218 chr1:46089804 CCDC17 0.65 12.15 0.56 2.54e-28 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs2290159 0.800 rs9849807 chr3:12675026 A/G cg23032965 chr3:12705835 RAF1 0.5 6.38 0.33 5.92e-10 Cholesterol, total; CRC cis rs7809950 1.000 rs2712200 chr7:107142435 G/T cg23024343 chr7:107201750 COG5 -0.63 -8.97 -0.44 2.37e-17 Coronary artery disease; CRC cis rs7178572 0.568 rs12913233 chr15:77543297 C/T cg22256960 chr15:77711686 NA -0.65 -9.54 -0.47 3.28e-19 Type 2 diabetes; CRC cis rs7772486 0.790 rs2250387 chr6:146205233 C/T cg23711669 chr6:146136114 FBXO30 0.7 12.41 0.56 2.94e-29 Lobe attachment (rater-scored or self-reported); CRC cis rs4908768 0.539 rs6666191 chr1:8658442 C/T cg20416874 chr1:8611966 RERE -0.4 -5.61 -0.3 4.25e-8 Neuroticism (multi-trait analysis);Subjective well-being (multi-trait analysis); CRC trans rs6500957 0.920 rs17648524 chr16:7459683 C/G cg10567034 chr11:70049203 FADD 0.4 6.03 0.32 4.35e-9 Spherical equivalent (joint analysis main effects and education interaction); CRC trans rs8035957 1.000 rs4924273 chr15:38846738 C/G cg19856771 chr13:42780042 DGKH -0.5 -6.23 -0.32 1.4e-9 Type 1 diabetes; CRC cis rs35995292 0.500 rs1019065 chr7:38939775 C/T cg19327137 chr7:38886074 VPS41 0.65 10.62 0.51 7.58e-23 Subjective well-being (multi-trait analysis); CRC cis rs7208859 0.673 rs3764420 chr17:29164154 A/G cg01831904 chr17:28903510 LRRC37B2 -0.55 -5.75 -0.3 2.01e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs11711311 1.000 rs9288983 chr3:113488699 A/G cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.51 -7.0 -0.36 1.44e-11 IgG glycosylation; CRC cis rs921968 0.643 rs1344645 chr2:219538019 A/C cg02176678 chr2:219576539 TTLL4 0.45 7.22 0.37 3.52e-12 Mean corpuscular hemoglobin concentration; CRC cis rs10504229 0.679 rs17804870 chr8:58158071 A/G cg02290350 chr8:58132656 NA -0.54 -5.83 -0.31 1.33e-8 Developmental language disorder (linguistic errors); CRC cis rs1577917 0.958 rs1816937 chr6:86557251 T/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.51 -6.59 -0.34 1.76e-10 Response to antipsychotic treatment; CRC cis rs1580019 0.961 rs3801328 chr7:32496930 T/C cg06627557 chr7:32535165 LSM5;AVL9 0.71 11.2 0.53 6.71e-25 Cognitive ability; CRC cis rs6089584 0.861 rs2180302 chr20:60576369 A/G cg13770153 chr20:60521292 NA -0.54 -9.0 -0.44 1.88e-17 Body mass index; CRC trans rs12188164 0.515 rs11745246 chr5:410943 A/G cg15371732 chr17:78194151 SLC26A11;SGSH 0.43 6.03 0.32 4.35e-9 Cystic fibrosis severity; CRC cis rs6831352 0.734 rs2851259 chr4:100033986 C/T cg12011299 chr4:100065546 ADH4 0.45 8.75 0.43 1.1e-16 Alcohol dependence; CRC trans rs12189452 0.507 rs4957723 chr5:107157011 C/T cg07112131 chr12:14926909 H2AFJ 0.39 6.15 0.32 2.3e-9 Intelligence (multi-trait analysis); CRC cis rs875971 0.520 rs2420597 chr7:65915986 A/G cg18876405 chr7:65276391 NA 0.51 8.36 0.42 1.77e-15 Aortic root size; CRC cis rs28386778 0.897 rs2584601 chr17:61940977 T/C cg25654072 chr17:61904446 PSMC5;FTSJ3 0.69 10.79 0.51 2.01e-23 Prudent dietary pattern; CRC cis rs56114371 0.530 rs169262 chr6:27770890 C/T cg15786705 chr6:28176104 NA 0.48 5.72 0.3 2.43e-8 Breast cancer; CRC cis rs514406 0.929 rs2607095 chr1:53325639 T/C cg27535305 chr1:53392650 SCP2 -0.37 -6.77 -0.35 5.99e-11 Monocyte count; CRC trans rs11039798 0.528 rs10839208 chr11:49030456 C/T cg15704280 chr7:45808275 SEPT13 0.59 6.24 0.33 1.34e-9 Axial length; CRC cis rs478304 0.651 rs4014192 chr11:65498915 C/T cg27068330 chr11:65405492 SIPA1 -0.63 -9.75 -0.47 6.92e-20 Acne (severe); CRC cis rs4713118 0.868 rs9468220 chr6:27732976 A/G cg06470822 chr6:28175283 NA -0.79 -8.87 -0.44 4.66e-17 Parkinson's disease; CRC cis rs2032447 0.507 rs199748 chr6:25909045 C/G cg12310025 chr6:25882481 NA -0.79 -11.51 -0.54 5.3e-26 Intelligence (multi-trait analysis); CRC trans rs1455244 0.700 rs7229302 chr18:11508904 G/T cg18852765 chr7:98030641 BAIAP2L1 0.38 6.11 0.32 2.89e-9 Schizophrenia; CRC cis rs889398 0.617 rs3790082 chr16:69896754 G/A cg00738113 chr16:70207722 CLEC18C -0.34 -5.9 -0.31 8.8e-9 Body mass index; CRC cis rs909674 0.818 rs8137426 chr22:39844350 T/G cg11247378 chr22:39784982 NA -0.36 -6.5 -0.34 3.02e-10 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; CRC cis rs2243480 1.000 rs6970243 chr7:65388490 C/A cg12463550 chr7:65579703 CRCP 0.63 6.04 0.32 4.17e-9 Diabetic kidney disease; CRC cis rs651907 0.557 rs11924013 chr3:101366698 G/A cg12386194 chr3:101231763 SENP7 0.46 6.68 0.35 1.01e-10 Colorectal cancer; CRC cis rs1008375 1.000 rs2058337 chr4:17678649 C/T cg16339924 chr4:17578868 LAP3 0.51 6.63 0.34 1.34e-10 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs6076065 0.676 rs6083085 chr20:23336119 C/T cg11657817 chr20:23433608 CST11 -0.42 -6.32 -0.33 8.62e-10 Facial morphology (factor 15, philtrum width); CRC cis rs6701037 0.681 rs34370567 chr1:175131340 C/T cg00321850 chr1:175162397 KIAA0040 -0.39 -6.48 -0.34 3.34e-10 Alcohol dependence; CRC cis rs344364 0.511 rs12599337 chr16:1946751 A/G cg03013636 chr16:1946785 NA -0.52 -6.39 -0.33 5.7e-10 Glomerular filtration rate in chronic kidney disease; CRC cis rs2188554 0.785 rs7789741 chr7:117206941 T/G cg09181792 chr7:117119393 CFTR 0.35 6.1 0.32 3.05e-9 Esophageal adenocarcinoma; CRC cis rs9393777 0.920 rs41269265 chr6:27425349 T/C cg15845792 chr6:28175446 NA 0.85 5.61 0.3 4.19e-8 Intelligence (multi-trait analysis); CRC cis rs2898681 0.581 rs730247 chr4:53680696 T/G cg00338735 chr4:53728038 RASL11B 0.39 5.92 0.31 8.08e-9 Optic nerve measurement (cup area); CRC cis rs1005224 1.000 rs1005224 chr14:76173860 A/T cg25116370 chr14:76127843 TTLL5;C14orf1 -0.4 -6.33 -0.33 7.98e-10 Large artery stroke; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg17115147 chr6:45345601 RUNX2;SUPT3H 0.42 7.1 0.36 7.83e-12 Liver disease severity in Alagille syndrome; CRC cis rs514406 0.861 rs562182 chr1:53270010 C/T cg27535305 chr1:53392650 SCP2 -0.37 -6.61 -0.34 1.57e-10 Monocyte count; CRC cis rs1129187 0.837 rs3763236 chr6:42902508 C/T cg26304593 chr6:42947056 PEX6 0.39 5.62 0.3 4.07e-8 Alzheimer's disease in APOE e4+ carriers; CRC cis rs514406 0.893 rs522287 chr1:53365493 C/T cg08859206 chr1:53392774 SCP2 -0.51 -8.0 -0.4 2.2e-14 Monocyte count; CRC cis rs7274811 0.625 rs293727 chr20:31933064 A/G cg03904042 chr20:32255491 NECAB3;C20orf134 0.41 6.24 0.33 1.34e-9 Height; CRC cis rs17376456 0.569 rs10057664 chr5:93182274 C/T cg25358565 chr5:93447407 FAM172A -0.66 -7.87 -0.4 5.07e-14 Diabetic retinopathy; CRC cis rs6938 0.596 rs11630918 chr15:75155896 C/T cg14664628 chr15:75095509 CSK -0.6 -9.35 -0.46 1.42e-18 Breast cancer; CRC cis rs10911390 0.793 rs75157509 chr1:183612214 C/T cg11505048 chr1:183622726 RGL1;APOBEC4 0.81 7.14 0.37 5.93e-12 Systemic lupus erythematosus; CRC cis rs992157 0.735 rs13392177 chr2:219112956 C/T cg04731861 chr2:219085781 ARPC2 0.31 6.72 0.35 7.78e-11 Colorectal cancer; CRC trans rs7819412 0.806 rs6980856 chr8:10938260 A/G cg06636001 chr8:8085503 FLJ10661 0.63 9.65 0.47 1.44e-19 Triglycerides; CRC trans rs7267979 0.934 rs2500399 chr20:25354694 T/G cg17903999 chr18:56338584 MALT1 0.41 6.74 0.35 7.13e-11 Liver enzyme levels (alkaline phosphatase); CRC cis rs932287 1.000 rs932287 chr11:9044767 A/G cg12365402 chr11:9010492 NRIP3 -0.36 -5.9 -0.31 8.85e-9 Colonoscopy-negative controls vs population controls; CRC cis rs13108904 0.539 rs13135102 chr4:1330983 A/C cg00684032 chr4:1343700 KIAA1530 0.6 8.37 0.42 1.69e-15 Obesity-related traits; CRC cis rs4478858 0.735 rs4949382 chr1:31776731 A/G cg00250761 chr1:31883323 NA -0.38 -7.22 -0.37 3.68e-12 Alcohol dependence; CRC cis rs4919694 1.000 rs112240253 chr10:104753726 C/T cg04362960 chr10:104952993 NT5C2 1.26 11.11 0.52 1.4e-24 Arsenic metabolism; CRC cis rs12594515 1.000 rs6493175 chr15:45989898 T/C cg19682013 chr15:45996608 NA 0.32 6.7 0.35 9.09e-11 Waist circumference;Weight; CRC cis rs2795502 1.000 rs2185717 chr10:43343875 G/A cg27426351 chr10:43362370 NA 0.59 7.09 0.36 8.28e-12 Blood protein levels; CRC cis rs12188164 0.965 rs72717435 chr5:448202 G/A cg26850624 chr5:429559 AHRR -0.81 -13.6 -0.6 9.63e-34 Cystic fibrosis severity; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg18058813 chr6:105307561 HACE1 -0.36 -6.05 -0.32 3.85e-9 Myopia (pathological); CRC cis rs9527 0.637 rs12219247 chr10:104613361 A/G cg15744005 chr10:104629667 AS3MT -0.4 -8.02 -0.4 1.91e-14 Arsenic metabolism; CRC cis rs6860806 0.661 rs2136187 chr5:131577894 T/C cg18758796 chr5:131593413 PDLIM4 0.46 8.57 0.43 4e-16 Breast cancer; CRC cis rs78456975 1.000 rs11883965 chr2:1560062 T/C cg01028140 chr2:1542097 TPO -0.58 -6.08 -0.32 3.28e-9 Placebo response in major depressive disorder (% change in symptom score); CRC cis rs11148252 0.553 rs9536236 chr13:53255012 T/A cg20354231 chr13:53171401 NA -0.49 -7.69 -0.39 1.77e-13 Lewy body disease; CRC cis rs12913538 0.962 rs12437894 chr15:62896799 A/G cg09983546 chr15:62884068 NA 0.61 9.63 0.47 1.68e-19 Sleep depth; CRC cis rs9303401 1.000 rs6503882 chr17:56915761 T/C cg12560992 chr17:57184187 TRIM37 0.43 5.64 0.3 3.58e-8 Cognitive test performance; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg24862861 chr10:976594 NA 0.45 6.74 0.35 7.21e-11 Intelligence (multi-trait analysis); CRC cis rs3752962 0.588 rs903164 chr17:1939502 G/A cg24156229 chr17:1948635 NA -0.78 -14.79 -0.63 2.74e-38 Itch intensity from mosquito bite; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg11454606 chr11:67888949 CHKA 0.43 7.87 0.4 5.29e-14 Liver disease severity in Alagille syndrome; CRC cis rs9928842 0.882 rs11641896 chr16:75300179 T/C cg09066997 chr16:75300724 BCAR1 0.64 5.91 0.31 8.68e-9 Alcoholic chronic pancreatitis; CRC cis rs7666738 0.785 rs11097614 chr4:99092175 G/C cg17366294 chr4:99064904 C4orf37 0.41 5.67 0.3 3.18e-8 Colonoscopy-negative controls vs population controls; CRC cis rs6502050 0.835 rs10163483 chr17:80110396 C/A cg22110888 chr17:80059540 CCDC57 0.4 6.44 0.33 4.17e-10 Life satisfaction; CRC cis rs10504229 0.595 rs116490935 chr8:58117531 A/G cg21724239 chr8:58056113 NA 0.52 7.13 0.37 6.58e-12 Developmental language disorder (linguistic errors); CRC cis rs9361491 0.543 rs1507153 chr6:79484386 C/A cg09184832 chr6:79620586 NA -0.46 -7.95 -0.4 3e-14 Intelligence (multi-trait analysis); CRC cis rs7945705 0.902 rs2568059 chr11:8884161 T/C cg12365402 chr11:9010492 NRIP3 -0.49 -8.3 -0.42 2.69e-15 Hemoglobin concentration; CRC cis rs1949733 1.000 rs2140337 chr4:8502112 A/G cg13073564 chr4:8508604 NA -0.49 -7.33 -0.37 1.85e-12 Response to antineoplastic agents; CRC cis rs2732480 0.577 rs2732466 chr12:48732459 A/G cg21466736 chr12:48725269 NA -0.61 -9.15 -0.45 5.99e-18 Hemoglobin concentration;Red blood cell count;Hematocrit; CRC cis rs921968 0.541 rs10200507 chr2:219335944 C/A cg02176678 chr2:219576539 TTLL4 -0.57 -9.18 -0.45 4.97e-18 Mean corpuscular hemoglobin concentration; CRC cis rs6502050 0.835 rs9900072 chr17:80114360 C/G cg25804541 chr17:80189381 SLC16A3 -0.3 -5.92 -0.31 8.17e-9 Life satisfaction; CRC cis rs76878669 0.561 rs4930177 chr11:66120784 T/C cg24851651 chr11:66362959 CCS -0.38 -6.69 -0.35 9.74e-11 Educational attainment (years of education); CRC cis rs35110281 0.776 rs9306159 chr21:45061839 G/T cg04455712 chr21:45112962 RRP1B 0.41 8.07 0.41 1.36e-14 Mean corpuscular volume; CRC cis rs2839186 0.770 rs2839984 chr21:47671690 A/G cg05896524 chr21:47604654 C21orf56 0.48 7.3 0.37 2.23e-12 Testicular germ cell tumor; CRC cis rs2732480 0.500 rs2450991 chr12:48651621 A/G cg04545296 chr12:48745243 ZNF641 0.33 5.71 0.3 2.52e-8 Hemoglobin concentration;Red blood cell count;Hematocrit; CRC cis rs2276314 1.000 rs2276314 chr18:33557466 C/T cg05985134 chr18:33552581 C18orf21 -0.52 -7.55 -0.38 4.37e-13 Endometriosis;Drug-induced torsades de pointes; CRC cis rs4423214 0.879 rs736894 chr11:71152258 A/G cg05163923 chr11:71159392 DHCR7 0.65 8.19 0.41 5.87e-15 Vitamin D levels; CRC cis rs4713118 0.955 rs9380010 chr6:27683572 A/G cg26587870 chr6:27730563 NA -0.42 -6.28 -0.33 1.05e-9 Parkinson's disease; CRC cis rs860772 0.500 rs1103852 chr1:158570890 A/C cg12129480 chr1:158549410 OR10X1 0.26 5.73 0.3 2.21e-8 Lymphocyte percentage of white cells; CRC cis rs6484504 0.625 rs4922859 chr11:31382517 A/G cg14844989 chr11:31128820 NA 0.34 6.18 0.32 1.89e-9 Red blood cell count; CRC cis rs7769051 0.522 rs6569852 chr6:133108333 C/A cg22852734 chr6:133119734 C6orf192 0.84 7.02 0.36 1.28e-11 Type 2 diabetes nephropathy; CRC cis rs208520 0.661 rs1776361 chr6:66822270 G/A cg07460842 chr6:66804631 NA -1.09 -15.17 -0.64 8.62e-40 Exhaled nitric oxide output; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg24715473 chr16:50059017 TMEM188 0.43 6.15 0.32 2.25e-9 Response to antipsychotic treatment; CRC cis rs3750082 0.889 rs7781915 chr7:32923159 T/C cg05721444 chr7:32995514 FKBP9 0.5 7.76 0.39 1.12e-13 Glomerular filtration rate (creatinine); CRC cis rs13118159 0.899 rs3796613 chr4:1353321 A/T cg02018176 chr4:1364513 KIAA1530 0.43 6.95 0.36 1.93e-11 Longevity; CRC cis rs1799949 1.000 rs8176083 chr17:41275151 G/C cg25072359 chr17:41440525 NA 0.43 6.38 0.33 5.87e-10 Menopause (age at onset); CRC cis rs4665809 0.556 rs10221814 chr2:26442759 C/T cg08067268 chr2:26466485 HADHB;HADHA -0.64 -8.33 -0.42 2.17e-15 Gut microbiome composition (summer); CRC cis rs2836974 0.899 rs68004583 chr21:40659587 T/C cg06238570 chr21:40685208 BRWD1 0.73 10.29 0.49 1.05e-21 Cognitive function; CRC cis rs11585357 0.895 rs34324150 chr1:17632464 C/G cg08277548 chr1:17600880 PADI3 -0.87 -11.37 -0.53 1.66e-25 Hair shape; CRC cis rs929354 0.772 rs10230895 chr7:157007038 T/C cg05182265 chr7:156933206 UBE3C -0.76 -14.49 -0.62 3.8e-37 Body mass index; CRC trans rs1455244 0.700 rs7229302 chr18:11508904 G/T cg23501767 chr5:133340570 VDAC1 0.41 6.3 0.33 9.56e-10 Schizophrenia; CRC cis rs4654899 0.680 rs11805006 chr1:21249603 C/T cg02927042 chr1:21476669 EIF4G3 -0.4 -6.21 -0.32 1.6e-9 Superior frontal gyrus grey matter volume; CRC trans rs8123881 0.733 rs7268466 chr20:15810676 C/T cg11625451 chr16:81349061 GAN 0.53 5.99 0.31 5.61e-9 Body mass index; CRC cis rs863345 0.584 rs10797023 chr1:158497079 T/C cg12129480 chr1:158549410 OR10X1 -0.29 -5.95 -0.31 6.94e-9 Pneumococcal bacteremia; CRC cis rs10540 1.000 rs116876680 chr11:517473 G/T cg08200582 chr11:442649 ANO9 -0.71 -7.33 -0.37 1.83e-12 Body mass index; CRC cis rs2404602 0.692 rs55676827 chr15:76961716 C/T cg22467129 chr15:76604101 ETFA -0.39 -6.54 -0.34 2.4e-10 Blood metabolite levels; CRC cis rs4713118 0.824 rs9468223 chr6:27740666 C/T cg12273811 chr6:28175739 NA 0.51 6.82 0.35 4.44e-11 Parkinson's disease; CRC cis rs10540 0.915 rs35389167 chr11:460765 A/G cg19913688 chr11:428466 ANO9 -0.72 -7.58 -0.39 3.58e-13 Body mass index; CRC cis rs2303759 0.918 rs1054770 chr19:49878115 G/A cg22590775 chr19:49891494 CCDC155 0.64 9.13 0.45 7.2e-18 Multiple sclerosis; CRC cis rs4711336 0.527 rs28651968 chr6:33717424 T/C cg14003231 chr6:33640908 ITPR3 0.44 7.08 0.36 8.83e-12 Height; CRC cis rs999943 0.846 rs10947422 chr6:33611351 G/A cg14003231 chr6:33640908 ITPR3 0.91 16.62 0.68 1.87e-45 Obesity (extreme); CRC trans rs11165623 0.792 rs12132069 chr1:96918809 A/C cg10631902 chr5:14652156 NA -0.51 -9.69 -0.47 1.04e-19 Hip circumference;Waist circumference; CRC cis rs9488822 0.676 rs868943 chr6:116337503 G/A cg26893134 chr6:116381904 FRK 0.27 7.8 0.4 8.28e-14 Cholesterol, total;LDL cholesterol; CRC cis rs7613875 0.600 rs2856237 chr3:50158774 A/G cg24110177 chr3:50126178 RBM5 0.61 9.5 0.46 4.6e-19 Body mass index; CRC cis rs4953076 0.573 rs2053456 chr2:44448632 G/A cg04920474 chr2:44395004 PPM1B 0.62 8.08 0.41 1.24e-14 Height; CRC trans rs561341 1.000 rs510264 chr17:30323414 A/G cg20587970 chr11:113659929 NA -1.43 -20.16 -0.74 1.97e-59 Hip circumference adjusted for BMI; CRC cis rs9296092 0.500 rs9469503 chr6:33527234 G/T cg13560919 chr6:33536144 NA -0.44 -6.28 -0.33 1.09e-9 Age at smoking initiation in chronic obstructive pulmonary disease; CRC cis rs9916302 0.731 rs11868030 chr17:37650332 A/G cg03013999 chr17:37608204 MED1 0.45 6.99 0.36 1.52e-11 Glomerular filtration rate (creatinine); CRC cis rs2444240 1.000 rs494965 chr11:120053650 C/T cg04390734 chr11:120039366 NA -0.28 -5.71 -0.3 2.58e-8 Corneal curvature; CRC cis rs875971 0.862 rs778724 chr7:65829291 T/C cg11764359 chr7:65958608 NA 0.59 9.19 0.45 4.42e-18 Aortic root size; CRC cis rs941873 0.868 rs10740497 chr10:81126380 T/C cg08514558 chr10:81106712 PPIF 0.37 5.89 0.31 9.56e-9 Height; CRC cis rs6120849 0.754 rs6120804 chr20:33623701 C/A cg08999081 chr20:33150536 PIGU 0.44 5.73 0.3 2.25e-8 Protein C levels; CRC cis rs66573146 1.000 rs9942188 chr4:6984181 C/T cg00086871 chr4:6988644 TBC1D14 1.02 7.7 0.39 1.65e-13 Granulocyte percentage of myeloid white cells; CRC cis rs7493 0.950 rs17166868 chr7:95033416 C/T cg19678392 chr7:94953810 PON1 -0.6 -7.49 -0.38 6.21e-13 Yu-Zhi constitution type in type 2 diabetes; CRC trans rs6546043 0.710 rs6546026 chr2:63923699 C/T cg20306022 chr2:7947960 NA -0.54 -6.09 -0.32 3.17e-9 Clozapine-induced agranulocytosis; CRC trans rs62103177 0.810 rs62103178 chr18:77624555 C/G cg05926928 chr17:57297772 GDPD1 1.06 9.93 0.48 1.71e-20 Opioid sensitivity; CRC cis rs6951245 1.000 rs78143408 chr7:1096846 G/A cg20603222 chr7:1096387 C7orf50;GPR146 -0.72 -8.67 -0.43 1.96e-16 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs1223397 0.651 rs2458314 chr6:13309224 C/T cg21538684 chr6:13274180 PHACTR1 0.4 6.48 0.34 3.37e-10 Blood pressure; CRC cis rs709400 1.000 rs58133129 chr14:104104759 A/G cg24130564 chr14:104152367 KLC1 -0.46 -6.82 -0.35 4.4e-11 Body mass index; CRC cis rs1552244 1.000 rs68067759 chr3:10150535 T/C cg00166722 chr3:10149974 C3orf24 0.69 9.14 0.45 6.54e-18 Alzheimer's disease; CRC cis rs3806843 0.735 rs801168 chr5:140080298 A/G cg19875535 chr5:140030758 IK -0.63 -10.58 -0.5 1.01e-22 Depressive symptoms (multi-trait analysis); CRC cis rs11098499 0.865 rs4507344 chr4:120307485 C/A cg24375607 chr4:120327624 NA 0.51 7.86 0.4 5.5e-14 Corneal astigmatism; CRC cis rs6456156 0.805 rs6909252 chr6:167527097 C/T cg07513332 chr6:167530253 CCR6 -0.46 -8.39 -0.42 1.45e-15 Primary biliary cholangitis; CRC cis rs7618501 0.521 rs952594 chr3:49908023 G/A cg05623727 chr3:50126028 RBM5 0.57 9.76 0.47 6.24e-20 Intelligence (multi-trait analysis); CRC cis rs10752881 0.967 rs12404594 chr1:182988027 G/A ch.1.3577855R chr1:183094577 LAMC1 0.81 13.42 0.59 4.64e-33 Colorectal cancer; CRC trans rs9929218 0.507 rs62057805 chr16:68742390 G/C cg04657470 chr2:198365150 HSPE1;HSPD1 1.04 20.51 0.75 8.58e-61 Colorectal cancer; CRC cis rs7849270 1.000 rs746489 chr9:131910093 G/T cg13538475 chr9:131942899 NA -0.29 -5.76 -0.3 1.9e-8 Blood metabolite ratios; CRC trans rs875971 0.660 rs2191268 chr7:66110224 C/T cg17608440 chr10:114912149 TCF7L2 0.37 6.08 0.32 3.26e-9 Aortic root size; CRC cis rs7726839 0.540 rs56325086 chr5:640728 G/A cg09021430 chr5:549028 NA -0.73 -8.27 -0.41 3.3e-15 Obesity-related traits; CRC cis rs992157 0.764 rs2891077 chr2:219184430 A/C cg04880052 chr2:219191631 PNKD 0.4 6.08 0.32 3.32e-9 Colorectal cancer; CRC cis rs755249 0.567 rs72661925 chr1:39669537 T/A cg18385671 chr1:39797026 MACF1 -0.41 -5.93 -0.31 7.46e-9 Peripheral arterial disease (traffic-related air pollution interaction); CRC trans rs1005277 0.579 rs2504148 chr10:38400788 A/G cg17830980 chr10:43048298 ZNF37B -0.6 -9.96 -0.48 1.36e-20 Extrinsic epigenetic age acceleration; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg21768436 chr8:67341108 RRS1 -0.39 -6.25 -0.33 1.26e-9 Myopia (pathological); CRC cis rs6460942 0.778 rs74993124 chr7:12462917 A/G cg03579179 chr7:12444095 VWDE -0.4 -5.68 -0.3 2.91e-8 Coronary artery disease; CRC cis rs1799949 1.000 rs35668327 chr17:41273095 G/A cg01879757 chr17:41196368 BRCA1 -0.43 -6.57 -0.34 1.94e-10 Menopause (age at onset); CRC cis rs1218582 0.772 rs4845688 chr1:154884142 T/C cg16680214 chr1:154839983 KCNN3 -0.46 -8.97 -0.44 2.22e-17 Prostate cancer; CRC cis rs7224685 0.539 rs2054039 chr17:4014538 C/A cg09597638 chr17:3907349 NA 0.56 9.53 0.47 3.59e-19 Type 2 diabetes; CRC cis rs10493773 0.609 rs12058974 chr1:86192235 T/A cg00734567 chr1:86172782 ZNHIT6 -0.49 -7.38 -0.38 1.3e-12 Urate levels in overweight individuals; CRC cis rs1401999 0.966 rs2037379 chr3:183650330 T/C cg20387954 chr3:183756860 HTR3D 0.46 7.69 0.39 1.68e-13 Anterior chamber depth; CRC cis rs7726839 0.540 rs28364691 chr5:664084 G/A cg09021430 chr5:549028 NA -0.72 -7.85 -0.4 5.9e-14 Obesity-related traits; CRC cis rs1005277 0.557 rs176887 chr10:38406094 T/C cg25517755 chr10:38738941 LOC399744 -0.45 -6.47 -0.34 3.64e-10 Extrinsic epigenetic age acceleration; CRC cis rs76878669 0.538 rs1785633 chr11:66107527 C/A cg24851651 chr11:66362959 CCS -0.38 -6.69 -0.35 9.66e-11 Educational attainment (years of education); CRC cis rs12291225 0.585 rs10832246 chr11:14380828 G/A cg19336497 chr11:14380999 RRAS2 -0.52 -9.12 -0.45 7.42e-18 Sense of smell; CRC cis rs10504229 0.593 rs17192845 chr8:58053339 C/T cg02290350 chr8:58132656 NA -0.62 -7.02 -0.36 1.27e-11 Developmental language disorder (linguistic errors); CRC cis rs8077889 0.672 rs1234612 chr17:41840802 A/G cg25876840 chr17:41920477 NA 0.41 6.49 0.34 3.22e-10 Triglycerides; CRC cis rs8060686 0.641 rs79577483 chr16:68036939 A/G cg09835421 chr16:68378352 PRMT7 -0.56 -5.69 -0.3 2.81e-8 HDL cholesterol;Metabolic syndrome; CRC cis rs933688 0.526 rs2973468 chr5:90540879 A/C cg26981201 chr5:90679533 LOC100129716;ARRDC3 -0.51 -5.95 -0.31 6.79e-9 Smoking behavior; CRC cis rs9910055 0.718 rs7212854 chr17:42254417 A/G cg09913183 chr17:42254507 C17orf65;ASB16 0.61 8.92 0.44 3.32e-17 Total body bone mineral density; CRC cis rs875971 0.862 rs778680 chr7:65840414 G/A cg18876405 chr7:65276391 NA 0.51 8.56 0.43 4.3e-16 Aortic root size; CRC cis rs1865760 0.613 rs9295674 chr6:25912342 A/G cg12310025 chr6:25882481 NA -0.47 -7.17 -0.37 4.94e-12 Height; CRC cis rs7119 0.717 rs10519167 chr15:77723027 G/T cg05673287 chr15:77411982 SGK269 -0.56 -8.71 -0.43 1.49e-16 Type 2 diabetes; CRC cis rs853679 0.517 rs34716816 chr6:28046169 C/A cg25164649 chr6:28176230 NA 0.72 9.1 0.45 9.16e-18 Depression; CRC cis rs9372498 0.505 rs72956993 chr6:118949708 A/T cg22561889 chr6:118971681 C6orf204 0.52 6.62 0.34 1.45e-10 Diastolic blood pressure; CRC cis rs1799949 0.965 rs12947782 chr17:41279882 A/G cg01879757 chr17:41196368 BRCA1 -0.43 -6.61 -0.34 1.54e-10 Menopause (age at onset); CRC trans rs9858542 1.000 rs9836291 chr3:49697459 G/A cg21665057 chr3:196295764 WDR53;FBXO45 -0.61 -8.02 -0.4 1.82e-14 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs1862618 0.671 rs252897 chr5:56223000 G/A cg22800045 chr5:56110881 MAP3K1 0.45 5.68 0.3 2.92e-8 Initial pursuit acceleration; CRC cis rs11105298 0.891 rs10777184 chr12:89919568 C/T cg08166232 chr12:89918718 WDR51B;GALNT4 -0.62 -7.81 -0.4 7.73e-14 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; CRC cis rs7224737 1.000 rs2014521 chr17:40283413 C/G cg00647820 chr17:40259828 DHX58 -0.46 -6.59 -0.34 1.78e-10 Fibrinogen levels; CRC cis rs9902453 0.817 rs2628170 chr17:28056612 T/A cg26525008 chr17:28256777 EFCAB5;SSH2 -0.62 -9.81 -0.48 4.2e-20 Coffee consumption (cups per day); CRC cis rs4808199 0.947 rs10401193 chr19:19591066 A/G cg03709012 chr19:19516395 GATAD2A 1.0 12.11 0.56 3.6e-28 Nonalcoholic fatty liver disease; CRC cis rs4555082 0.834 rs2735825 chr14:105710900 G/A cg18132624 chr14:105716052 BTBD6;BRF1 -0.51 -8.17 -0.41 6.81e-15 Mean platelet volume;Platelet distribution width; CRC cis rs1881797 0.527 rs79724455 chr1:247646957 T/C cg21399703 chr1:247681439 NA 0.51 5.75 0.3 2e-8 Acute lymphoblastic leukemia (childhood); CRC cis rs2832191 0.765 rs2832162 chr21:30461808 G/A cg24692254 chr21:30365293 RNF160 0.8 14.56 0.63 2.02e-37 Dental caries; CRC cis rs7772486 0.558 rs702322 chr6:146007166 G/A cg13319975 chr6:146136371 FBXO30 0.63 9.13 0.45 7.11e-18 Lobe attachment (rater-scored or self-reported); CRC cis rs2304069 0.826 rs245076 chr5:149350648 C/T cg22760475 chr5:149380129 HMGXB3;TIGD6 0.45 6.08 0.32 3.4e-9 HIV-1 control; CRC cis rs4731207 0.564 rs6466970 chr7:124592755 A/G cg23710748 chr7:124431027 NA -0.38 -6.08 -0.32 3.35e-9 Cutaneous malignant melanoma; CRC cis rs6089584 0.528 rs4925335 chr20:60627034 G/A cg06108461 chr20:60628389 TAF4 -0.74 -11.99 -0.55 1.01e-27 Body mass index; CRC cis rs367615 0.512 rs814153 chr5:108667829 A/C cg17395555 chr5:108820864 NA 0.38 6.89 0.36 2.84e-11 Colorectal cancer (SNP x SNP interaction); CRC cis rs1799949 1.000 rs11655505 chr17:41278377 G/A cg19454999 chr17:41278357 BRCA1;NBR2 0.55 8.63 0.43 2.68e-16 Menopause (age at onset); CRC cis rs7772486 0.686 rs1011596 chr6:146076433 A/G cg13319975 chr6:146136371 FBXO30 -0.43 -6.49 -0.34 3.12e-10 Lobe attachment (rater-scored or self-reported); CRC cis rs2075371 0.829 rs11770764 chr7:134003308 T/C cg02659138 chr7:134003124 SLC35B4 0.43 7.38 0.38 1.28e-12 Mean platelet volume; CRC cis rs2439831 0.850 rs3759790 chr15:44121030 G/A cg02155558 chr15:43621948 ADAL;LCMT2 0.64 7.26 0.37 2.89e-12 Lung cancer in ever smokers; CRC cis rs6502050 0.769 rs9916231 chr17:80119645 A/G cg13198984 chr17:80129470 CCDC57 0.48 8.5 0.42 6.74e-16 Life satisfaction; CRC cis rs4665809 0.590 rs6716858 chr2:26423414 G/A cg25036284 chr2:26402008 FAM59B -0.54 -7.43 -0.38 9.45e-13 Gut microbiome composition (summer); CRC cis rs9427116 0.702 rs9427108 chr1:154607914 G/A cg17218026 chr1:154582156 ADAR 0.63 10.3 0.49 9.85e-22 Blood protein levels; CRC cis rs7959452 0.535 rs4761228 chr12:69682327 G/A cg20891283 chr12:69753455 YEATS4 0.78 13.21 0.59 2.84e-32 Blood protein levels; CRC trans rs9393777 0.778 rs35608615 chr6:27040402 G/C cg06606381 chr12:133084897 FBRSL1 -0.84 -6.56 -0.34 2.11e-10 Intelligence (multi-trait analysis); CRC cis rs10097731 0.901 rs9298344 chr8:82043063 C/T cg25230327 chr8:82042993 NA -0.93 -13.69 -0.6 4.32e-34 Serum total protein level; CRC cis rs6598955 0.724 rs12754536 chr1:26639605 T/C cg04990556 chr1:26633338 UBXN11 -0.75 -12.42 -0.57 2.56e-29 Obesity-related traits; CRC cis rs3768617 0.510 rs10797838 chr1:183077020 A/G ch.1.3577855R chr1:183094577 LAMC1 0.85 15.38 0.65 1.4e-40 Fuchs's corneal dystrophy; CRC trans rs7696796 0.761 rs7670273 chr4:183162207 C/G cg03635442 chr8:49427283 NA -0.47 -6.03 -0.32 4.4e-9 Neuroticism; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg06221861 chr7:100425075 EPHB4 0.37 6.26 0.33 1.22e-9 Liver disease severity in Alagille syndrome; CRC cis rs694739 0.628 rs475032 chr11:64140737 G/C cg02228329 chr11:64053129 BAD;GPR137 -0.43 -6.04 -0.32 4.22e-9 Alopecia areata;Crohn's disease;Psoriasis vulgaris; CRC cis rs9768139 0.733 rs13225172 chr7:158120334 G/A cg25566285 chr7:158114605 PTPRN2 0.45 7.06 0.36 1.02e-11 Calcium levels; CRC cis rs2153535 0.601 rs9379224 chr6:8538413 A/G cg21535247 chr6:8435926 SLC35B3 0.48 7.35 0.38 1.61e-12 Motion sickness; CRC cis rs1005277 0.579 rs2472183 chr10:38392495 T/G cg25517755 chr10:38738941 LOC399744 -0.44 -6.41 -0.33 5.05e-10 Extrinsic epigenetic age acceleration; CRC cis rs35883536 0.967 rs1981134 chr1:101111205 G/T cg14515779 chr1:101123966 NA 0.39 7.21 0.37 3.93e-12 Monocyte count; CRC cis rs9467711 0.606 rs9393708 chr6:26362643 C/T cg14345882 chr6:26364793 BTN3A2 -0.65 -5.74 -0.3 2.12e-8 Autism spectrum disorder or schizophrenia; CRC trans rs970548 0.657 rs11239572 chr10:46088061 C/T cg14222797 chr10:16859974 RSU1 0.62 6.41 0.33 5.02e-10 Total cholesterol levels;Cholesterol, total;HDL cholesterol;HDL cholesterol levels; CRC cis rs11245387 0.633 rs2086945 chr10:126543993 C/T cg08799069 chr10:126477246 METTL10 0.54 7.17 0.37 4.88e-12 Response to bronchodilator in chronic obstructive pulmonary disease (change in FEV1); CRC cis rs881375 1.000 rs4323544 chr9:123647377 C/T cg14255062 chr9:123606675 PSMD5;LOC253039 0.43 6.15 0.32 2.28e-9 Rheumatoid arthritis; CRC trans rs4942242 0.583 rs9594986 chr13:44229595 C/T cg19169023 chr15:41853346 TYRO3 -0.46 -6.74 -0.35 6.91e-11 Response to tocilizumab in rheumatoid arthritis; CRC cis rs6582630 0.599 rs1851114 chr12:38424671 C/T cg13010199 chr12:38710504 ALG10B -0.4 -5.7 -0.3 2.63e-8 Drug-induced liver injury (flucloxacillin); CRC cis rs4665809 0.590 rs13006973 chr2:26454707 C/T cg27170947 chr2:26402098 FAM59B 0.59 7.71 0.39 1.53e-13 Gut microbiome composition (summer); CRC cis rs4862750 0.794 rs1030382 chr4:187903782 T/G cg11301795 chr4:187892539 NA -0.87 -18.92 -0.72 1.47e-54 Lobe attachment (rater-scored or self-reported); CRC cis rs6547741 0.844 rs7382 chr2:27873415 G/A cg27432699 chr2:27873401 GPN1 -0.86 -16.85 -0.68 2.27e-46 Oral cavity cancer; CRC cis rs6089584 0.546 rs6061980 chr20:60618877 G/A cg23262073 chr20:60523788 NA -0.39 -6.18 -0.32 1.89e-9 Body mass index; CRC cis rs12249377 0.519 rs7906960 chr10:92586205 A/G cg14313238 chr10:92632228 RPP30 0.47 6.57 0.34 2e-10 White matter microstructure (global fractional anisotropy); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg22303846 chr2:152145870 NMI 0.42 6.04 0.32 4.08e-9 Response to antipsychotic treatment; CRC trans rs7267979 0.844 rs6132824 chr20:25238173 T/C cg17903999 chr18:56338584 MALT1 -0.41 -6.6 -0.34 1.7e-10 Liver enzyme levels (alkaline phosphatase); CRC cis rs56307353 0.753 rs62129495 chr19:1962789 T/C cg02376178 chr19:1969988 CSNK1G2 0.58 9.17 0.45 5.35e-18 Coronary artery disease; CRC trans rs1945213 0.694 rs1384099 chr11:55866040 A/C cg03929089 chr4:120376271 NA 0.55 6.35 0.33 7.07e-10 Acute lymphoblastic leukemia (childhood); CRC cis rs72615157 0.561 rs113844570 chr7:99873778 A/C cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.48 5.64 0.3 3.58e-8 Lung function (FEV1/FVC); CRC cis rs9818758 0.607 rs80170003 chr3:48951640 T/C cg00383909 chr3:49044727 WDR6 1.4 12.47 0.57 1.65e-29 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; CRC cis rs4595586 0.563 rs11169769 chr12:39233134 C/G cg26384229 chr12:38710491 ALG10B 0.54 6.65 0.34 1.23e-10 Morning vs. evening chronotype; CRC trans rs61931739 0.500 rs6416261 chr12:34540377 T/C cg13010199 chr12:38710504 ALG10B 0.45 6.52 0.34 2.65e-10 Morning vs. evening chronotype; CRC trans rs875971 0.660 rs2191268 chr7:66110224 C/T cg02090014 chr7:156802340 MNX1 -0.37 -6.33 -0.33 7.81e-10 Aortic root size; CRC cis rs875971 0.862 rs801195 chr7:66026115 A/G cg18252515 chr7:66147081 NA 0.43 6.23 0.32 1.44e-9 Aortic root size; CRC trans rs7824557 0.603 rs2246606 chr8:11219334 G/A cg16141378 chr3:129829833 LOC729375 -0.45 -6.59 -0.34 1.74e-10 Retinal vascular caliber; CRC cis rs4400599 0.594 rs7526644 chr1:154208753 T/C cg26808167 chr1:154192205 UBAP2L;C1orf43 -0.36 -5.83 -0.31 1.31e-8 Platelet distribution width; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg04557695 chr7:92466167 CDK6 0.38 6.36 0.33 6.65e-10 Liver disease severity in Alagille syndrome; CRC trans rs11098499 0.863 rs2306456 chr4:120472422 C/G cg25214090 chr10:38739885 LOC399744 0.67 10.46 0.5 2.64e-22 Corneal astigmatism; CRC cis rs2645694 0.626 rs2703121 chr4:77822328 C/G cg18351406 chr4:77819688 ANKRD56 0.5 7.5 0.38 5.95e-13 Emphysema distribution in smoking; CRC cis rs62458065 0.640 rs10271491 chr7:32530665 C/A cg20159608 chr7:32802032 NA -0.59 -7.06 -0.36 9.71e-12 Metabolite levels (HVA/MHPG ratio); CRC cis rs7833790 0.724 rs12676336 chr8:82771008 C/T cg17211192 chr8:82754475 SNX16 0.47 6.61 0.34 1.54e-10 Diastolic blood pressure; CRC cis rs9649213 0.574 rs6979373 chr7:97961844 T/C cg24562669 chr7:97807699 LMTK2 0.43 7.06 0.36 9.7e-12 Prostate cancer (SNP x SNP interaction); CRC cis rs6089584 0.854 rs8117075 chr20:60613766 T/C cg06108461 chr20:60628389 TAF4 -0.92 -15.83 -0.66 2.41e-42 Body mass index; CRC cis rs2404602 0.647 rs11631959 chr15:77040048 T/C cg03037974 chr15:76606532 NA -0.56 -8.67 -0.43 1.99e-16 Blood metabolite levels; CRC cis rs7692995 1.000 rs6831102 chr4:18018236 T/C cg08925142 chr4:18023851 LCORL -0.51 -5.81 -0.3 1.5e-8 Height; CRC cis rs6681460 1.000 rs10889634 chr1:67065911 A/G cg02459107 chr1:67143332 SGIP1 -0.48 -8.4 -0.42 1.34e-15 Presence of antiphospholipid antibodies; CRC cis rs12476592 0.602 rs262526 chr2:63899478 C/T cg10828910 chr2:63850056 LOC388955 0.51 6.49 0.34 3.11e-10 Childhood ear infection; CRC cis rs6570726 0.935 rs425717 chr6:145838620 A/T cg05347473 chr6:146136440 FBXO30 0.37 6.0 0.31 5.27e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs1008375 0.898 rs61047804 chr4:17593965 G/A cg02297831 chr4:17616191 MED28 0.43 5.61 0.3 4.33e-8 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs11148252 0.716 rs2760772 chr13:52780373 C/G cg00495681 chr13:53174319 NA 0.56 8.04 0.41 1.67e-14 Lewy body disease; CRC cis rs3749237 0.537 rs4459909 chr3:49469217 T/C cg03060546 chr3:49711283 APEH 0.61 10.33 0.49 7.72e-22 Resting heart rate; CRC cis rs4731207 0.596 rs11767649 chr7:124637517 C/T cg23710748 chr7:124431027 NA 0.44 6.88 0.35 3.07e-11 Cutaneous malignant melanoma; CRC cis rs25422 0.938 rs62421538 chr6:118729703 A/T cg15382696 chr6:118971807 C6orf204 0.6 7.66 0.39 2.05e-13 Renal cell carcinoma; CRC cis rs56011263 0.687 rs4690293 chr4:706101 A/G cg05835009 chr4:710272 PCGF3 0.52 6.99 0.36 1.49e-11 White blood cell count; CRC trans rs2014572 0.967 rs7259978 chr19:57756129 C/T cg02674126 chr19:40336878 FBL 0.43 6.91 0.36 2.58e-11 Hyperactive-impulsive symptoms; CRC cis rs7224685 0.569 rs7215798 chr17:4007666 C/G cg05562828 chr17:3906858 NA -0.46 -5.9 -0.31 9.01e-9 Type 2 diabetes; CRC cis rs6714710 0.603 rs956039 chr2:98416848 C/A cg26665480 chr2:98280029 ACTR1B 0.56 7.47 0.38 7.19e-13 Posterior cortical atrophy and Alzheimer's disease; CRC cis rs2380220 0.516 rs7748108 chr6:96008082 T/C cg23517279 chr6:96025343 MANEA 0.48 5.96 0.31 6.43e-9 Behavioural disinhibition (generation interaction); CRC cis rs9462027 0.628 rs2296360 chr6:34803558 C/G cg07306190 chr6:34760872 UHRF1BP1 -0.34 -6.09 -0.32 3.16e-9 Systemic lupus erythematosus; CRC cis rs769267 0.930 rs892021 chr19:19613480 T/C cg01262667 chr19:19385393 TM6SF2 0.36 5.96 0.31 6.35e-9 Tonsillectomy; CRC cis rs8072100 0.713 rs8074451 chr17:45477573 C/T cg25173405 chr17:45401733 C17orf57 -0.46 -6.83 -0.35 4.16e-11 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs929354 0.713 rs6946947 chr7:156948787 T/C cg17757837 chr7:157058334 UBE3C 0.74 12.39 0.56 3.31e-29 Body mass index; CRC cis rs870825 0.616 rs7680835 chr4:185652992 C/G cg07424746 chr4:185654737 MLF1IP 0.51 5.69 0.3 2.8e-8 Blood protein levels; CRC cis rs1577917 0.740 rs9344533 chr6:86236188 C/A cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A 0.57 7.85 0.4 5.94e-14 Response to antipsychotic treatment; CRC cis rs7635838 0.619 rs347616 chr3:11277927 G/A cg00170343 chr3:11313890 ATG7 0.55 8.39 0.42 1.44e-15 HDL cholesterol; CRC cis rs11098499 0.909 rs28581362 chr4:120283548 T/A cg09307838 chr4:120376055 NA 0.68 10.53 0.5 1.51e-22 Corneal astigmatism; CRC cis rs7692995 0.920 rs6849629 chr4:18009488 A/G cg08925142 chr4:18023851 LCORL -0.51 -5.74 -0.3 2.2e-8 Height; CRC cis rs4665809 0.525 rs10865402 chr2:26535383 A/G cg08067268 chr2:26466485 HADHB;HADHA -0.46 -6.0 -0.31 5.25e-9 Gut microbiome composition (summer); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg22738278 chr10:104220943 TMEM180 0.4 5.98 0.31 5.73e-9 Intelligence (multi-trait analysis); CRC cis rs6952808 0.689 rs4719391 chr7:2048136 T/C cg02951883 chr7:2050386 MAD1L1 -0.74 -12.32 -0.56 6.37e-29 Bipolar disorder and schizophrenia; CRC trans rs7647973 0.593 rs28535523 chr3:49848414 C/T cg21659725 chr3:3221576 CRBN 0.66 7.35 0.38 1.63e-12 Menarche (age at onset); CRC cis rs9393777 0.513 rs9368450 chr6:26652489 A/C cg12292205 chr6:26970375 C6orf41 -0.62 -6.9 -0.36 2.66e-11 Intelligence (multi-trait analysis); CRC trans rs3780486 0.846 rs10113903 chr9:33122645 C/G cg20290983 chr6:43655470 MRPS18A -1.15 -25.79 -0.82 5.58e-81 IgG glycosylation; CRC cis rs6502050 0.835 rs6502070 chr17:80112634 G/A cg22110888 chr17:80059540 CCDC57 0.4 6.38 0.33 6.15e-10 Life satisfaction; CRC cis rs9435341 0.965 rs1762482 chr1:107599002 A/C cg15468180 chr1:107600409 PRMT6 -0.41 -6.29 -0.33 1.01e-9 Facial morphology (factor 21, depth of nasal alae); CRC cis rs801193 1.000 rs62466793 chr7:66191517 G/A cg18876405 chr7:65276391 NA 0.6 10.48 0.5 2.39e-22 Aortic root size; CRC cis rs72945132 0.882 rs3900797 chr11:70186614 C/T cg00319359 chr11:70116639 PPFIA1 0.65 7.24 0.37 3.14e-12 Coronary artery disease; CRC cis rs172166 0.694 rs9295760 chr6:28147385 G/A cg12273811 chr6:28175739 NA 0.62 9.03 0.45 1.52e-17 Cardiac Troponin-T levels; CRC cis rs7463659 1.000 rs7836944 chr8:135436202 A/G cg17885191 chr8:135476712 NA 0.45 6.84 0.35 3.84e-11 Colonoscopy-negative controls vs population controls; CRC cis rs10197940 0.510 rs7557092 chr2:152423459 T/A cg06191203 chr2:152266755 RIF1 -0.59 -7.32 -0.37 1.88e-12 Lung cancer; CRC cis rs6543140 0.964 rs7561351 chr2:103077780 A/G cg04239558 chr2:103089729 SLC9A4 0.37 6.58 0.34 1.83e-10 Blood protein levels; CRC cis rs7666738 0.830 rs35560671 chr4:99069095 G/A cg17366294 chr4:99064904 C4orf37 0.43 7.32 0.37 1.87e-12 Colonoscopy-negative controls vs population controls; CRC cis rs6534441 0.857 rs28507630 chr4:125460069 C/A cg21609808 chr4:125404261 NA 0.39 5.77 0.3 1.85e-8 Major depressive disorder; CRC trans rs208520 0.837 rs208509 chr6:66941706 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.92 -12.0 -0.55 9.55e-28 Exhaled nitric oxide output; CRC cis rs798554 0.660 rs2644295 chr7:2860217 A/C cg17321639 chr7:2759063 NA -0.4 -6.03 -0.32 4.4e-9 Height; CRC cis rs1799949 0.602 rs8176235 chr17:41219560 C/T cg05368731 chr17:41323189 NBR1 0.63 8.31 0.42 2.6e-15 Menopause (age at onset); CRC cis rs10791323 0.628 rs2851118 chr11:133705995 A/C cg03690763 chr11:133734501 NA -0.34 -5.73 -0.3 2.33e-8 Childhood ear infection; CRC trans rs208520 0.837 rs208486 chr6:66926255 A/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.93 -12.05 -0.55 5.89e-28 Exhaled nitric oxide output; CRC trans rs2727020 0.617 rs1917311 chr11:49422665 C/T cg11707556 chr5:10655725 ANKRD33B -0.38 -7.23 -0.37 3.43e-12 Coronary artery disease; CRC trans rs4853036 0.586 rs35286755 chr2:70005173 T/G cg14633329 chr9:139640053 LCN6 -0.39 -6.39 -0.33 5.63e-10 Colorectal or endometrial cancer; CRC cis rs2857891 0.909 rs56261447 chr11:6939382 A/C cg14883916 chr11:6947541 ZNF215 0.59 6.26 0.33 1.21e-9 Response to cytadine analogues (cytosine arabinoside); CRC cis rs7811142 1.000 rs113738841 chr7:100081306 C/T cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.73 9.87 0.48 2.71e-20 Platelet count; CRC cis rs1005277 0.579 rs9299760 chr10:38377920 C/T cg25517755 chr10:38738941 LOC399744 -0.44 -6.39 -0.33 5.65e-10 Extrinsic epigenetic age acceleration; CRC trans rs7615952 0.932 rs13321217 chr3:125631771 G/A cg00769240 chr8:12517080 NA -0.57 -6.84 -0.35 3.87e-11 Blood pressure (smoking interaction); CRC cis rs7119 0.671 rs10152850 chr15:77904426 G/A cg27398640 chr15:77910606 LINGO1 0.42 7.72 0.39 1.43e-13 Type 2 diabetes; CRC cis rs6089584 0.927 rs2296081 chr20:60572663 G/T cg18761221 chr20:60518478 NA 0.41 7.26 0.37 2.9e-12 Body mass index; CRC cis rs11252926 0.507 rs4881199 chr10:428090 C/G cg16386425 chr10:429943 DIP2C -0.47 -7.35 -0.38 1.55e-12 Psychosis in Alzheimer's disease; CRC cis rs11958404 0.932 rs72816585 chr5:157433901 A/C cg05962755 chr5:157440814 NA 1.01 12.88 0.58 5.12e-31 IgG glycosylation; CRC cis rs28386778 0.897 rs2665797 chr17:61922485 C/G cg23090583 chr17:61904693 PSMC5;FTSJ3 -1.01 -19.58 -0.73 3.71e-57 Prudent dietary pattern; CRC cis rs7914558 1.000 rs11191577 chr10:104902165 A/G cg15744005 chr10:104629667 AS3MT -0.34 -7.27 -0.37 2.57e-12 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC trans rs3733585 0.673 rs4519796 chr4:9955936 A/G cg26043149 chr18:55253948 FECH -0.5 -7.7 -0.39 1.56e-13 Cleft plate (environmental tobacco smoke interaction); CRC cis rs4474465 1.000 rs11237508 chr11:78173297 C/T cg27205649 chr11:78285834 NARS2 -0.47 -5.78 -0.3 1.77e-8 Alzheimer's disease (survival time); CRC cis rs9488822 0.676 rs12202181 chr6:116327102 A/G cg15226275 chr6:116381976 FRK 0.3 8.5 0.42 6.55e-16 Cholesterol, total;LDL cholesterol; CRC cis rs1046896 0.739 rs28459016 chr17:80741194 G/A cg19500275 chr17:80737654 TBCD 0.53 7.47 0.38 7.17e-13 Glycated hemoglobin levels; CRC cis rs11785400 0.793 rs11543967 chr8:143739435 A/G cg24634471 chr8:143751801 JRK -0.47 -6.28 -0.33 1.1e-9 Schizophrenia; CRC cis rs1218582 0.774 rs4845679 chr1:154861187 G/T cg24250549 chr1:154909240 PMVK 0.55 8.83 0.44 6.46e-17 Prostate cancer; CRC cis rs6938 0.514 rs35556055 chr15:75253414 G/A cg05627522 chr15:75251581 NA 0.5 7.54 0.38 4.55e-13 Breast cancer; CRC trans rs2018683 0.621 rs10261556 chr7:28976636 G/T cg19402173 chr7:128379420 CALU -0.48 -6.88 -0.35 3.12e-11 Response to irinotecan and platinum-based chemotherapy in non-small-cell lung cancer; CRC cis rs6504622 0.577 rs197915 chr17:44990522 A/G cg16759221 chr17:45003025 GOSR2 -0.62 -10.02 -0.48 8.57e-21 Orofacial clefts; CRC cis rs1862618 0.802 rs986049 chr5:56110233 G/A cg18230493 chr5:56204884 C5orf35 -0.72 -9.26 -0.45 2.7e-18 Initial pursuit acceleration; CRC cis rs3858526 0.584 rs10769276 chr11:5868020 G/T cg05234568 chr11:5960015 NA -0.66 -9.54 -0.47 3.31e-19 DNA methylation (variation); CRC cis rs7589728 1.000 rs7589728 chr2:88518440 G/A cg07952391 chr2:88470173 THNSL2 0.62 6.27 0.33 1.15e-9 Plasma clusterin levels; CRC cis rs2075371 0.966 rs2544223 chr7:133995787 A/G cg02659138 chr7:134003124 SLC35B4 0.4 6.9 0.36 2.6e-11 Mean platelet volume; CRC trans rs7395662 1.000 rs7107184 chr11:48577069 G/T cg21153622 chr11:89784906 NA -0.47 -7.57 -0.39 3.82e-13 HDL cholesterol; CRC cis rs1691799 0.899 rs1168302 chr12:66737518 C/T cg16791601 chr12:66731901 HELB -0.73 -12.61 -0.57 5.09e-30 White blood cell count (basophil); CRC cis rs9926296 0.656 rs2376882 chr16:89827002 T/C cg04287289 chr16:89883240 FANCA 0.55 8.61 0.43 3.15e-16 Vitiligo; CRC cis rs4555082 0.834 rs2735825 chr14:105710900 G/A cg13114125 chr14:105738426 BRF1 -0.83 -12.14 -0.56 2.89e-28 Mean platelet volume;Platelet distribution width; CRC cis rs12476592 0.543 rs262531 chr2:63904951 A/C cg10828910 chr2:63850056 LOC388955 0.5 6.24 0.33 1.38e-9 Childhood ear infection; CRC trans rs3942852 0.568 rs10769313 chr11:48097466 A/G cg15704280 chr7:45808275 SEPT13 -0.68 -9.57 -0.47 2.73e-19 Acute lymphoblastic leukemia (childhood); CRC cis rs13191362 0.935 rs7767254 chr6:162954674 T/G cg21926612 chr6:163149169 PACRG;PARK2 0.83 10.42 0.5 3.71e-22 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs6964587 0.626 rs10280301 chr7:91524258 A/T cg17063962 chr7:91808500 NA -0.58 -9.14 -0.45 6.77e-18 Breast cancer; CRC cis rs7827545 0.545 rs6988000 chr8:135559534 C/T cg17885191 chr8:135476712 NA 0.62 7.49 0.38 6.2800000000000005e-13 Hypertension (SNP x SNP interaction); CRC trans rs6479874 0.831 rs2660211 chr10:52747861 C/T cg15483030 chr1:5935144 NPHP4 -0.71 -6.34 -0.33 7.64e-10 Migraine; CRC cis rs853679 0.517 rs868987 chr6:28110148 A/G cg25164649 chr6:28176230 NA -0.77 -9.82 -0.48 4.09e-20 Depression; CRC cis rs2952156 0.959 rs1565922 chr17:37831035 A/G cg20243544 chr17:37824526 PNMT 0.56 8.74 0.43 1.2e-16 Asthma; CRC cis rs6951245 1.000 rs77346188 chr7:1114023 C/A cg03188948 chr7:1209495 NA 0.64 6.65 0.34 1.2e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs9611565 0.659 rs1569516 chr22:41910244 C/T cg17554472 chr22:41940697 POLR3H -0.54 -5.67 -0.3 3.14e-8 Vitiligo; CRC cis rs3820068 0.705 rs41270255 chr1:15892980 G/A cg27534772 chr1:16042836 PLEKHM2 0.45 7.5 0.38 6.07e-13 Systolic blood pressure; CRC cis rs7617480 0.519 rs6790914 chr3:49206318 G/C cg03060546 chr3:49711283 APEH 0.48 7.06 0.36 1e-11 Subjective well-being (multi-trait analysis);Menarche (age at onset); CRC trans rs11039798 1.000 rs3902928 chr11:48581458 A/T cg03929089 chr4:120376271 NA 0.61 6.06 0.32 3.67e-9 Axial length; CRC cis rs9649213 0.593 rs7807455 chr7:97957622 C/A cg24562669 chr7:97807699 LMTK2 0.44 7.27 0.37 2.66e-12 Prostate cancer (SNP x SNP interaction); CRC cis rs9916302 0.706 rs1874226 chr17:37729031 C/T cg20243544 chr17:37824526 PNMT -0.48 -5.64 -0.3 3.7e-8 Glomerular filtration rate (creatinine); CRC cis rs11585357 0.842 rs72633804 chr1:17617024 T/C cg08277548 chr1:17600880 PADI3 -0.89 -11.28 -0.53 3.61e-25 Hair shape; CRC cis rs9926296 0.585 rs8058009 chr16:89856439 G/A cg21285383 chr16:89894308 SPIRE2 0.36 5.81 0.31 1.46e-8 Vitiligo; CRC cis rs28489187 0.706 rs233095 chr1:85824816 T/C cg17737388 chr1:85724454 C1orf52 0.37 5.61 0.3 4.2e-8 Asymmetrical dimethylarginine levels;Serum dimethylarginine levels (asymmetric/symetric ratio); CRC cis rs7647973 0.516 rs4499638 chr3:49202782 C/G cg03060546 chr3:49711283 APEH 0.41 5.77 0.3 1.79e-8 Menarche (age at onset); CRC cis rs7726839 0.540 rs72703079 chr5:595173 T/C cg16447950 chr5:562315 NA -0.71 -9.55 -0.47 3.07e-19 Obesity-related traits; CRC cis rs7618501 0.633 rs2526751 chr3:50064867 T/C cg24110177 chr3:50126178 RBM5 0.47 7.13 0.37 6.43e-12 Intelligence (multi-trait analysis); CRC cis rs244731 0.959 rs9313752 chr5:176645435 G/T cg06060754 chr5:176797920 RGS14 -0.62 -7.94 -0.4 3.17e-14 Urate levels in lean individuals; CRC cis rs2213920 0.523 rs7857923 chr9:118176789 A/G cg13918206 chr9:118159781 DEC1 0.62 5.88 0.31 1.03e-8 Docetaxel-induced peripheral neuropathy in metastatic castrate-resistant prostate cancer; CRC trans rs9903692 0.954 rs7212202 chr17:46132723 G/C cg13910583 chr8:56987998 RPS20 -0.44 -5.99 -0.31 5.63e-9 Pulse pressure; CRC cis rs684232 0.623 rs391002 chr17:535441 T/G cg15660573 chr17:549704 VPS53 -0.86 -15.79 -0.66 3.27e-42 Prostate cancer; CRC cis rs1862618 0.853 rs832582 chr5:56177743 G/A cg20203395 chr5:56204925 C5orf35 -0.72 -8.29 -0.42 2.99e-15 Initial pursuit acceleration; CRC cis rs11122272 0.735 rs2250704 chr1:231486647 A/G cg06096015 chr1:231504339 EGLN1 0.39 5.91 0.31 8.42e-9 Hemoglobin concentration; CRC cis rs875971 0.929 rs778712 chr7:65849978 C/T cg18912574 chr7:65842487 NCRNA00174 0.36 6.18 0.32 1.88e-9 Aortic root size; CRC cis rs1008375 1.000 rs3815413 chr4:17654648 T/C cg04450456 chr4:17643702 FAM184B 0.37 5.78 0.3 1.77e-8 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs10504229 1.000 rs17805602 chr8:58179915 A/G cg22535103 chr8:58192502 C8orf71 -0.82 -12.27 -0.56 9.63e-29 Developmental language disorder (linguistic errors); CRC cis rs4713118 0.739 rs2893931 chr6:27748010 G/A cg15845792 chr6:28175446 NA 0.68 8.92 0.44 3.35e-17 Parkinson's disease; CRC cis rs71403859 0.502 rs8053720 chr16:71456142 C/G cg08717414 chr16:71523259 ZNF19 -0.72 -7.92 -0.4 3.74e-14 Post bronchodilator FEV1; CRC cis rs736408 0.609 rs1029871 chr3:52797634 G/C cg11645453 chr3:52864694 ITIH4 0.37 6.49 0.34 3.07e-10 Bipolar disorder; CRC cis rs9303280 0.868 rs11650661 chr17:38026286 A/T cg11212589 chr17:38028394 ZPBP2 0.46 8.71 0.43 1.5e-16 Self-reported allergy; CRC cis rs4332037 0.539 rs55993248 chr7:2071132 A/G cg02421172 chr7:1938701 MAD1L1 0.42 5.69 0.3 2.77e-8 Bipolar disorder; CRC cis rs7394190 0.935 rs4746140 chr10:75417249 G/C cg26549892 chr10:75416844 SYNPO2L -0.49 -6.35 -0.33 7.02e-10 Incident atrial fibrillation; CRC cis rs7937682 0.814 rs1619652 chr11:111469757 G/A cg19812747 chr11:111475976 SIK2 -0.57 -9.58 -0.47 2.42e-19 Primary sclerosing cholangitis; CRC cis rs3750082 0.852 rs34724897 chr7:32899526 T/A cg05721444 chr7:32995514 FKBP9 -0.48 -7.3 -0.37 2.16e-12 Glomerular filtration rate (creatinine); CRC cis rs10876993 0.928 rs1689595 chr12:58056763 C/T cg18357645 chr12:58087776 OS9 0.58 8.15 0.41 7.81e-15 Celiac disease or Rheumatoid arthritis; CRC cis rs10979 0.894 rs6924940 chr6:143906183 C/T cg25407410 chr6:143891975 LOC285740 -0.77 -12.14 -0.56 2.92e-28 Hypospadias; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg01858300 chr15:41233997 NA 0.44 7.23 0.37 3.39e-12 Liver disease severity in Alagille syndrome; CRC cis rs6570726 0.846 rs9399559 chr6:145945778 C/T cg13319975 chr6:146136371 FBXO30 -0.43 -6.42 -0.33 4.84e-10 Lobe attachment (rater-scored or self-reported); CRC cis rs4243830 0.850 rs7552196 chr1:6590502 G/A cg22792644 chr1:6614718 TAS1R1;NOL9 -0.71 -8.47 -0.42 8.14e-16 Body mass index; CRC cis rs7772486 0.790 rs6926076 chr6:146232804 C/T cg13319975 chr6:146136371 FBXO30 0.41 6.15 0.32 2.25e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs7666738 0.791 rs6532725 chr4:99061479 T/C cg17366294 chr4:99064904 C4orf37 0.44 7.49 0.38 6.54e-13 Colonoscopy-negative controls vs population controls; CRC cis rs3733585 0.673 rs9994937 chr4:9964799 G/T cg11266682 chr4:10021025 SLC2A9 -0.47 -9.64 -0.47 1.58e-19 Cleft plate (environmental tobacco smoke interaction); CRC cis rs853679 0.517 rs9380055 chr6:28081629 A/G cg15845792 chr6:28175446 NA 1.0 13.1 0.59 7.81e-32 Depression; CRC cis rs10256972 0.721 rs2030959 chr7:1075906 T/C cg22907277 chr7:1156413 C7orf50 0.5 7.44 0.38 9.05e-13 Longevity;Endometriosis; CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg21774377 chr6:34760070 UHRF1BP1 -0.49 -6.07 -0.32 3.52e-9 Diisocyanate-induced asthma; CRC cis rs910316 0.967 rs175505 chr14:75529619 C/T cg03030879 chr14:75389066 RPS6KL1 0.45 6.96 0.36 1.89e-11 Height; CRC trans rs6604635 0.695 rs6658528 chr1:216722090 A/G cg15689795 chr4:2439478 NA 0.32 6.02 0.31 4.56e-9 Gut microbiome composition (summer); CRC cis rs1003719 0.788 rs1543748 chr21:38446581 T/C cg10648535 chr21:38446584 PIGP;TTC3 0.54 7.59 0.39 3.29e-13 Eye color traits; CRC trans rs9929218 0.954 rs4485355 chr16:68754730 C/T cg04657470 chr2:198365150 HSPE1;HSPD1 -0.96 -14.39 -0.62 9.54e-37 Colorectal cancer; CRC cis rs7618501 0.572 rs4688756 chr3:50040194 T/A cg24110177 chr3:50126178 RBM5 -0.45 -6.82 -0.35 4.33e-11 Intelligence (multi-trait analysis); CRC cis rs1008375 0.966 rs2286773 chr4:17616214 C/A cg16339924 chr4:17578868 LAP3 0.55 7.46 0.38 7.79e-13 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs10097731 0.901 rs10464892 chr8:82042991 A/G cg25230327 chr8:82042993 NA 0.88 13.29 0.59 1.49e-32 Serum total protein level; CRC cis rs9486719 1.000 rs6921291 chr6:97066242 C/T cg06623918 chr6:96969491 KIAA0776 -0.79 -9.27 -0.46 2.55e-18 Migraine;Coronary artery disease; CRC cis rs3768617 0.528 rs3736888 chr1:183084607 A/G ch.1.3577855R chr1:183094577 LAMC1 0.89 15.85 0.66 1.97e-42 Fuchs's corneal dystrophy; CRC cis rs597539 0.652 rs478647 chr11:68700424 C/T cg06028808 chr11:68637592 NA 0.37 5.9 0.31 9.24e-9 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs67478160 0.634 rs2144079 chr14:104258884 C/T cg08213375 chr14:104286397 PPP1R13B 0.58 11.91 0.55 1.87e-27 Schizophrenia; CRC trans rs17685 0.753 rs1806885 chr7:75785612 T/G cg19862616 chr7:65841803 NCRNA00174 0.98 18.08 0.71 3.12e-51 Coffee consumption;Coffee consumption (cups per day); CRC cis rs1008375 1.000 rs7659718 chr4:17638020 A/C cg02297831 chr4:17616191 MED28 0.48 6.44 0.33 4.31e-10 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs9902453 1.000 rs4465650 chr17:28396721 C/G cg26525008 chr17:28256777 EFCAB5;SSH2 0.58 8.78 0.44 9.03e-17 Coffee consumption (cups per day); CRC trans rs8108034 0.920 rs30480 chr19:39807213 A/G cg09731288 chr10:112632370 PDCD4 -0.51 -6.03 -0.32 4.42e-9 Lung adenocarcinoma; CRC cis rs9916302 0.706 rs1874226 chr17:37729031 C/T cg07936489 chr17:37558343 FBXL20 0.88 10.91 0.52 7.53e-24 Glomerular filtration rate (creatinine); CRC cis rs6860806 0.507 rs273912 chr5:131661349 A/C cg22638593 chr5:131593259 PDLIM4 -0.38 -6.3 -0.33 9.32e-10 Breast cancer; CRC cis rs5769765 0.773 rs9616382 chr22:50312979 C/T cg22709217 chr22:50311962 ALG12;CRELD2 -1.12 -18.26 -0.71 6.49e-52 Schizophrenia; CRC cis rs12142240 0.698 rs45517837 chr1:46859225 A/G cg14993813 chr1:46806288 NSUN4 -0.48 -6.03 -0.32 4.47e-9 Menopause (age at onset); CRC cis rs6502050 0.871 rs6502051 chr17:80059332 A/C cg02741985 chr17:80059408 CCDC57 -0.46 -7.54 -0.38 4.53e-13 Life satisfaction; CRC cis rs877282 0.945 rs10904556 chr10:789429 A/G cg06581033 chr10:766294 NA -0.51 -5.62 -0.3 4.1e-8 Uric acid levels; CRC cis rs763121 0.706 rs3827356 chr22:39064806 G/T cg06544989 chr22:39130855 UNC84B -0.39 -6.0 -0.31 5.1e-9 Menopause (age at onset); CRC cis rs4713118 0.869 rs9468214 chr6:27713299 G/C cg02683197 chr6:28174875 NA 0.62 8.4 0.42 1.39e-15 Parkinson's disease; CRC cis rs78456975 1.000 rs10177095 chr2:1570976 C/A cg26248373 chr2:1572462 NA -0.71 -8.13 -0.41 8.56e-15 Placebo response in major depressive disorder (% change in symptom score); CRC cis rs801193 1.000 rs4279493 chr7:66226620 C/T cg00343986 chr7:65444356 GUSB 0.49 7.19 0.37 4.31e-12 Aortic root size; CRC cis rs597539 0.552 rs6591361 chr11:68719284 T/C cg06112835 chr11:68658793 MRPL21 0.39 6.18 0.32 1.89e-9 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC trans rs2727020 0.566 rs10839234 chr11:49185524 C/T cg21153622 chr11:89784906 NA -0.43 -7.1 -0.36 7.75e-12 Coronary artery disease; CRC cis rs6912958 0.935 rs6454629 chr6:88165515 A/G cg12350822 chr6:88032061 C6orf162;GJB7 -0.36 -6.83 -0.35 4.02e-11 Monocyte percentage of white cells; CRC cis rs6951245 0.786 rs77943789 chr7:1140158 C/T cg21664854 chr7:1097933 C7orf50;GPR146 0.72 8.5 0.42 6.95e-16 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs950169 0.922 rs11639244 chr15:84832650 G/A cg17507749 chr15:85114479 UBE2QP1 0.77 11.41 0.53 1.28e-25 Schizophrenia; CRC trans rs7944735 0.671 rs7106731 chr11:48003392 T/G cg15704280 chr7:45808275 SEPT13 0.55 7.17 0.37 5.11e-12 Intraocular pressure; CRC cis rs8141529 0.748 rs5762882 chr22:29290680 C/A cg02153584 chr22:29168773 CCDC117 0.46 6.58 0.34 1.86e-10 Lymphocyte counts; CRC cis rs858239 0.600 rs7776644 chr7:23119307 C/T cg23682824 chr7:23144976 KLHL7 0.43 5.66 0.3 3.29e-8 Cerebrospinal fluid biomarker levels; CRC trans rs7027930 0.598 rs7022858 chr9:569681 G/A cg27061366 chr19:13044373 FARSA 0.5 6.0 0.31 5.28e-9 Pulmonary function decline; CRC cis rs9462846 0.959 rs7750915 chr6:42882067 C/T cg21280719 chr6:42927975 GNMT -0.34 -5.86 -0.31 1.15e-8 Blood protein levels; CRC cis rs34787248 1 rs34787248 chr6:28197886 C/T cg21251018 chr6:28226885 NKAPL 0.53 6.26 0.33 1.17e-9 Autism spectrum disorder or schizophrenia; CRC cis rs8072100 0.738 rs9895509 chr17:45549618 A/T cg25173405 chr17:45401733 C17orf57 0.41 6.21 0.32 1.6e-9 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs904251 0.861 rs914349 chr6:37484715 A/C cg25019722 chr6:37503610 NA -0.48 -8.93 -0.44 3.03e-17 Cognitive performance; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg06439982 chr16:2802372 SRRM2;LOC100128788 0.48 6.71 0.35 8.38e-11 Anxiety disorder; CRC cis rs6120849 0.663 rs6088662 chr20:33547633 A/C cg08999081 chr20:33150536 PIGU 0.45 5.86 0.31 1.09e-8 Protein C levels; CRC cis rs9303401 0.538 rs35454383 chr17:56475599 C/T cg02118635 chr17:56770003 RAD51C;TEX14 0.74 8.59 0.43 3.47e-16 Cognitive test performance; CRC cis rs9910055 0.573 rs228768 chr17:42191893 A/C cg19774624 chr17:42201019 HDAC5 -0.45 -6.18 -0.32 1.94e-9 Total body bone mineral density; CRC cis rs13191362 1.000 rs60719662 chr6:163006643 A/C cg21926612 chr6:163149169 PACRG;PARK2 0.76 11.15 0.52 1.03e-24 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs10504229 1.000 rs3814486 chr8:58191226 A/T cg02290350 chr8:58132656 NA -0.42 -5.96 -0.31 6.62e-9 Developmental language disorder (linguistic errors); CRC cis rs7113874 0.569 rs11041962 chr11:8549623 C/T cg17679104 chr11:8615758 STK33 -0.35 -5.9 -0.31 8.91e-9 Body mass index in physically active individuals;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs9733 0.565 rs7524620 chr1:150616699 C/T cg15448220 chr1:150897856 SETDB1 -0.45 -6.6 -0.34 1.67e-10 Tonsillectomy; CRC cis rs4700695 0.764 rs36299 chr5:65348120 G/T cg21114390 chr5:65439923 SFRS12 0.59 7.19 0.37 4.36e-12 Facial morphology (factor 19); CRC cis rs713477 0.967 rs4243600 chr14:55910679 A/G cg13175173 chr14:55914753 NA -0.52 -9.85 -0.48 3.19e-20 Pediatric bone mineral content (femoral neck); CRC cis rs875971 0.558 rs4433015 chr7:65639723 A/C cg00343986 chr7:65444356 GUSB -0.48 -7.13 -0.37 6.25e-12 Aortic root size; CRC cis rs28386778 0.897 rs4968662 chr17:61834537 A/G cg25654072 chr17:61904446 PSMC5;FTSJ3 0.71 11.11 0.52 1.42e-24 Prudent dietary pattern; CRC cis rs1008375 0.933 rs6449324 chr4:17694880 G/C cg16339924 chr4:17578868 LAP3 0.48 6.39 0.33 5.57e-10 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs4731207 0.655 rs7808203 chr7:124502136 T/C cg23710748 chr7:124431027 NA -0.38 -6.08 -0.32 3.42e-9 Cutaneous malignant melanoma; CRC cis rs11191205 0.644 rs74926559 chr10:103378309 G/A cg15320455 chr10:103880129 LDB1 0.59 6.47 0.34 3.64e-10 Intelligence (multi-trait analysis); CRC cis rs832540 0.931 rs1466008 chr5:56213406 G/C cg12311346 chr5:56204834 C5orf35 -0.51 -7.97 -0.4 2.58e-14 Coronary artery disease; CRC cis rs8060686 0.858 rs13334918 chr16:67901343 A/G cg26727032 chr16:67993705 SLC12A4 -0.71 -11.74 -0.54 8.32e-27 HDL cholesterol;Metabolic syndrome; CRC cis rs17209837 0.831 rs56223611 chr7:87083157 C/A cg00919237 chr7:87102261 ABCB4 -0.47 -5.7 -0.3 2.61e-8 Gallbladder cancer; CRC cis rs10751667 0.666 rs6597966 chr11:950750 T/C cg23136738 chr11:925521 AP2A2 -0.41 -7.01 -0.36 1.32e-11 Alzheimer's disease (late onset); CRC cis rs66569888 0.523 rs4522599 chr2:106926004 G/C cg23109721 chr2:106886537 NA 0.43 5.75 0.3 1.99e-8 Facial morphology (factor 23); CRC cis rs8180040 0.903 rs13094438 chr3:47277885 G/A cg10298567 chr3:47292165 KIF9 -0.39 -6.36 -0.33 6.69e-10 Colorectal cancer; CRC cis rs1862618 0.802 rs832560 chr5:56124423 T/A cg18230493 chr5:56204884 C5orf35 -0.69 -9.12 -0.45 7.72e-18 Initial pursuit acceleration; CRC cis rs992157 0.835 rs7585702 chr2:219146607 T/C cg04880052 chr2:219191631 PNKD -0.44 -6.93 -0.36 2.2e-11 Colorectal cancer; CRC cis rs4713118 0.587 rs9393899 chr6:28133528 G/C cg21251018 chr6:28226885 NKAPL 0.48 6.17 0.32 2.02e-9 Parkinson's disease; CRC cis rs4665809 0.590 rs13387855 chr2:26420708 T/G cg25036284 chr2:26402008 FAM59B -0.6 -7.65 -0.39 2.29e-13 Gut microbiome composition (summer); CRC cis rs2692947 0.637 rs72492201 chr2:96630201 G/A cg23100626 chr2:96804247 ASTL 0.26 7.03 0.36 1.18e-11 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; CRC cis rs6502050 0.805 rs62078303 chr17:80085210 A/G cg25804541 chr17:80189381 SLC16A3 0.31 5.9 0.31 8.94e-9 Life satisfaction; CRC cis rs4730250 0.707 rs10253291 chr7:106786550 C/A cg02696742 chr7:106810147 HBP1 0.57 6.5 0.34 2.93e-10 Osteoarthritis; CRC cis rs8060686 0.920 rs3809630 chr16:67879400 G/A cg26727032 chr16:67993705 SLC12A4 -0.56 -6.86 -0.35 3.37e-11 HDL cholesterol;Metabolic syndrome; CRC trans rs13046373 0.905 rs4816372 chr21:32077414 A/T cg23414876 chr16:67197396 HSF4;FBXL8 -0.28 -6.6 -0.34 1.62e-10 HDL cholesterol; CRC cis rs9372498 0.536 rs9489458 chr6:118920503 G/A cg22561889 chr6:118971681 C6orf204 0.5 6.39 0.33 5.8e-10 Diastolic blood pressure; CRC cis rs208520 0.690 rs3899423 chr6:66835285 A/G cg07460842 chr6:66804631 NA -1.07 -14.61 -0.63 1.36e-37 Exhaled nitric oxide output; CRC cis rs1046896 0.627 rs7225515 chr17:80795783 C/T cg19046167 chr17:80928561 B3GNTL1 0.48 6.73 0.35 7.59e-11 Glycated hemoglobin levels; CRC cis rs3796619 1.000 rs1466214 chr4:1073760 C/T cg11579758 chr4:1086637 RNF212 0.4 6.61 0.34 1.58e-10 Recombination rate (males); CRC cis rs4664293 0.647 rs6714917 chr2:160449453 A/C cg08347373 chr2:160653686 CD302 -0.39 -6.49 -0.34 3.12e-10 Monocyte percentage of white cells; CRC cis rs1941023 0.503 rs7952244 chr11:60132164 G/A cg08716584 chr11:60157161 MS4A7 -0.53 -8.87 -0.44 4.92e-17 Congenital heart disease (maternal effect); CRC cis rs13315871 1.000 rs9850717 chr3:58351875 C/T cg20936604 chr3:58311152 NA -0.69 -6.43 -0.33 4.38e-10 Cholesterol, total; CRC cis rs1865760 0.827 rs9295680 chr6:25944103 T/C cg16482183 chr6:26056742 HIST1H1C 0.51 7.34 0.37 1.72e-12 Height; CRC cis rs73206853 0.563 rs11830452 chr12:111198576 A/T cg12870014 chr12:110450643 ANKRD13A 0.73 8.42 0.42 1.19e-15 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC cis rs172166 0.611 rs203882 chr6:28078502 G/A cg17949981 chr6:28129498 ZNF389 0.41 5.62 0.3 4.15e-8 Cardiac Troponin-T levels; CRC cis rs4629710 0.592 rs9492877 chr6:131562577 C/G cg12606694 chr6:131520996 AKAP7 0.56 8.32 0.42 2.39e-15 Multiple myeloma (IgH translocation); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg01200289 chr4:77227751 STBD1 0.48 7.45 0.38 8.17e-13 Liver disease severity in Alagille syndrome; CRC cis rs6502050 0.605 rs35158616 chr17:80094480 A/G cg13198984 chr17:80129470 CCDC57 0.45 7.8 0.4 8.04e-14 Life satisfaction; CRC cis rs2404602 0.583 rs3759853 chr15:76587777 C/T cg22467129 chr15:76604101 ETFA -0.47 -8.28 -0.42 3.19e-15 Blood metabolite levels; CRC cis rs7412746 0.611 rs12410869 chr1:150856153 G/T cg17724175 chr1:150552817 MCL1 0.43 6.5 0.34 2.96e-10 Melanoma; CRC trans rs960902 0.747 rs13009200 chr2:37712496 C/A cg19040518 chr10:75570762 NDST2 -0.43 -5.97 -0.31 6.28e-9 Response to TNF-alpha inhibitors in rheumatoid arthritis; CRC cis rs1153858 1.000 rs67744121 chr15:45677237 C/G cg14582100 chr15:45693742 SPATA5L1 0.28 5.72 0.3 2.41e-8 Homoarginine levels; CRC cis rs1030877 0.557 rs2576752 chr2:105978761 A/G cg02079111 chr2:105885981 TGFBRAP1 0.48 7.53 0.38 4.79e-13 Obesity-related traits; CRC cis rs13118159 0.742 rs7679860 chr4:1333987 C/T cg20887711 chr4:1340912 KIAA1530 0.43 5.84 0.31 1.22e-8 Longevity; CRC cis rs9640161 0.711 rs55881542 chr7:150025734 G/A cg13722127 chr7:150037890 RARRES2 0.53 8.03 0.4 1.73e-14 Blood protein levels;Circulating chemerin levels; CRC cis rs9443645 0.869 rs9343827 chr6:79501036 A/G cg05283184 chr6:79620031 NA -0.57 -9.16 -0.45 5.54e-18 Intelligence (multi-trait analysis); CRC trans rs7618501 0.635 rs7635002 chr3:49989155 T/G cg21659725 chr3:3221576 CRBN 0.59 9.2 0.45 4.38e-18 Intelligence (multi-trait analysis); CRC trans rs10982213 0.830 rs2274163 chr9:117188714 C/T cg01643284 chr12:105629755 APPL2 0.4 6.42 0.33 4.79e-10 Interleukin-6 levels; CRC cis rs13108904 0.521 rs4974609 chr4:1356924 A/C cg24560729 chr4:1342394 KIAA1530 -0.4 -7.28 -0.37 2.49e-12 Obesity-related traits; CRC cis rs4713118 0.786 rs200502 chr6:27788062 C/T cg15786705 chr6:28176104 NA 0.5 6.19 0.32 1.81e-9 Parkinson's disease; CRC cis rs9303401 0.580 rs2013166 chr17:56637630 C/T cg02118635 chr17:56770003 RAD51C;TEX14 0.78 9.77 0.47 5.98e-20 Cognitive test performance; CRC cis rs477895 1.000 rs1047206 chr11:64089216 C/G cg23719950 chr11:63933701 MACROD1 -0.58 -5.84 -0.31 1.25e-8 Mean platelet volume; CRC cis rs7917772 0.582 rs10786680 chr10:104317192 A/G cg11453585 chr10:104263688 ACTR1A;SUFU 0.84 15.74 0.66 5.14e-42 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC cis rs4665809 1.000 rs6704930 chr2:26325705 G/A cg27170947 chr2:26402098 FAM59B -0.46 -6.1 -0.32 2.93e-9 Gut microbiome composition (summer); CRC cis rs2404602 0.669 rs12441484 chr15:77109875 G/A cg22467129 chr15:76604101 ETFA -0.39 -6.37 -0.33 6.48e-10 Blood metabolite levels; CRC cis rs9611565 0.607 rs132792 chr22:42062822 C/T cg03806693 chr22:41940476 POLR3H 0.65 9.07 0.45 1.11e-17 Vitiligo; CRC trans rs10983614 1.000 rs7867776 chr9:120072627 A/G cg04841346 chr1:145096723 SEC22B 0.46 6.1 0.32 2.93e-9 Survival in pancreatic cancer; CRC cis rs8072100 0.817 rs9905581 chr17:45547185 C/T cg25173405 chr17:45401733 C17orf57 -0.44 -6.81 -0.35 4.57e-11 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs951366 0.764 rs823143 chr1:205743425 A/C cg11965913 chr1:205819406 PM20D1 0.84 13.86 0.61 1e-34 Menarche (age at onset); CRC cis rs7615952 0.576 rs12497295 chr3:125818650 G/A cg04553112 chr3:125709451 NA -0.53 -6.06 -0.32 3.68e-9 Blood pressure (smoking interaction); CRC cis rs12701220 0.901 rs12701708 chr7:1090333 C/T cg06145435 chr7:1022769 CYP2W1 0.38 5.83 0.31 1.31e-8 Bronchopulmonary dysplasia; CRC cis rs17253792 0.822 rs75399477 chr14:56174413 T/C cg01858014 chr14:56050164 KTN1 -0.91 -6.39 -0.33 5.79e-10 Putamen volume; CRC cis rs1552244 1.000 rs112847840 chr3:10101652 C/T cg10729496 chr3:10149963 C3orf24 0.55 7.26 0.37 2.73e-12 Alzheimer's disease; CRC cis rs1215050 0.740 rs1214994 chr4:99035577 C/T cg05340658 chr4:99064831 C4orf37 0.48 7.22 0.37 3.55e-12 Waist-to-hip ratio adjusted for body mass index; CRC cis rs2228479 0.702 rs3819574 chr16:89826630 G/A cg19635926 chr16:89946313 TCF25 0.63 5.68 0.3 3.01e-8 Skin colour saturation; CRC cis rs7772486 0.875 rs7767660 chr6:146436550 T/C cg13319975 chr6:146136371 FBXO30 -0.39 -5.98 -0.31 5.76e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs7119 0.717 rs8032071 chr15:77745762 C/T cg17802220 chr15:77601643 NA 0.45 6.16 0.32 2.13e-9 Type 2 diabetes; CRC cis rs7487075 0.820 rs10785617 chr12:46699243 T/C cg22049899 chr12:47219821 SLC38A4 0.33 6.13 0.32 2.48e-9 Itch intensity from mosquito bite; CRC cis rs10078 0.528 rs2434697 chr5:466811 T/C cg07599136 chr5:415885 AHRR 0.71 7.04 0.36 1.12e-11 Fat distribution (HIV); CRC cis rs11247915 0.561 rs12750420 chr1:26608649 G/A cg04990556 chr1:26633338 UBXN11 -0.47 -5.78 -0.3 1.71e-8 Obesity-related traits; CRC cis rs3796352 0.764 rs11714902 chr3:53101544 G/C cg07884673 chr3:53033167 SFMBT1 0.7 5.82 0.31 1.42e-8 Immune reponse to smallpox (secreted IL-2); CRC cis rs3796352 1.000 rs3806692 chr3:53080987 C/G cg06204229 chr3:52865917 ITIH4 0.48 6.01 0.31 4.85e-9 Immune reponse to smallpox (secreted IL-2); CRC cis rs3796352 1.000 rs35720014 chr3:52982110 A/C cg06204229 chr3:52865917 ITIH4 0.5 5.71 0.3 2.51e-8 Immune reponse to smallpox (secreted IL-2); CRC cis rs9611565 0.659 rs116959331 chr22:41932774 A/G cg03806693 chr22:41940476 POLR3H -1.12 -14.99 -0.64 4.54e-39 Vitiligo; CRC cis rs875971 0.862 rs6460290 chr7:65809106 G/A cg12463550 chr7:65579703 CRCP -0.53 -7.56 -0.38 4e-13 Aortic root size; CRC cis rs4319547 0.695 rs4758643 chr12:122924819 A/T cg23029597 chr12:123009494 RSRC2 -0.54 -6.71 -0.35 8.41e-11 Body mass index; CRC cis rs4731207 0.724 rs10224946 chr7:124531338 C/T cg23710748 chr7:124431027 NA -0.38 -6.06 -0.32 3.65e-9 Cutaneous malignant melanoma; CRC cis rs10971721 0.822 rs12376279 chr9:33804254 A/G cg13495928 chr9:33750294 PRSS3 0.56 5.89 0.31 9.66e-9 Body mass index; CRC cis rs6973256 0.605 rs6467499 chr7:133348922 G/T cg10665199 chr7:133106180 EXOC4 -0.49 -7.77 -0.39 9.85e-14 Intelligence (multi-trait analysis); CRC cis rs4253772 0.637 rs9627350 chr22:46663017 A/G cg24881330 chr22:46731750 TRMU 0.69 7.91 0.4 4.08e-14 LDL cholesterol;Cholesterol, total; CRC cis rs519973 0.930 rs541115 chr3:187638092 T/A cg10168494 chr3:187635183 NA 0.5 8.76 0.43 1.04e-16 Allergic disease (asthma, hay fever or eczema); CRC cis rs6502050 0.761 rs9908277 chr17:80060829 T/C cg13198984 chr17:80129470 CCDC57 -0.39 -6.48 -0.34 3.26e-10 Life satisfaction; CRC cis rs13256369 0.901 rs4841015 chr8:8567140 C/G cg06636001 chr8:8085503 FLJ10661 0.45 5.69 0.3 2.76e-8 Obesity-related traits; CRC cis rs225245 0.755 rs226441 chr17:34033072 C/T cg05299278 chr17:33885742 SLFN14 0.49 7.99 0.4 2.36e-14 Reticulocyte count;Reticulocyte fraction of red cells;High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells; CRC cis rs780096 0.526 rs11126999 chr2:27670307 G/A cg27432699 chr2:27873401 GPN1 -0.61 -9.33 -0.46 1.56e-18 Total body bone mineral density; CRC cis rs6066835 1.000 rs6066833 chr20:47354494 G/C cg18078177 chr20:47281410 PREX1 0.61 5.64 0.3 3.73e-8 Multiple myeloma; CRC cis rs875971 0.862 rs1968126 chr7:66057004 A/G cg12463550 chr7:65579703 CRCP -0.47 -6.36 -0.33 6.73e-10 Aortic root size; CRC cis rs1801251 1.000 rs2674839 chr2:233669040 G/C cg25237894 chr2:233734115 C2orf82 0.55 8.84 0.44 5.88e-17 Coronary artery disease; CRC cis rs524281 0.817 rs10791849 chr11:65890597 T/A cg16950941 chr11:66035639 RAB1B -0.61 -7.52 -0.38 5.31e-13 Electroencephalogram traits; CRC cis rs3820068 0.581 rs6669417 chr1:15922371 G/T cg13390004 chr1:15929781 NA 0.49 6.89 0.36 2.82e-11 Systolic blood pressure; CRC cis rs4665809 0.549 rs3828255 chr2:26413252 G/A cg26119090 chr2:26468346 HADHA;HADHB 0.97 11.84 0.55 3.53e-27 Gut microbiome composition (summer); CRC cis rs896854 1.000 rs13255935 chr8:95965685 C/A cg09323728 chr8:95962352 TP53INP1 -0.42 -6.73 -0.35 7.55e-11 Type 2 diabetes; CRC cis rs1799949 0.683 rs55737636 chr17:41264739 C/T cg25072359 chr17:41440525 NA 0.53 8.33 0.42 2.29e-15 Menopause (age at onset); CRC cis rs12541635 0.966 rs7819043 chr8:106989783 T/C cg10147462 chr8:107024639 NA 0.42 6.9 0.36 2.74e-11 Age of smoking initiation; CRC cis rs9807989 0.839 rs6543123 chr2:102977196 C/T cg03938978 chr2:103052716 IL18RAP 0.37 6.07 0.32 3.47e-9 Asthma; CRC trans rs1005277 0.522 rs9417256 chr10:37976990 A/G cg17830980 chr10:43048298 ZNF37B -0.42 -6.63 -0.34 1.41e-10 Extrinsic epigenetic age acceleration; CRC cis rs10751667 0.643 rs10794352 chr11:946294 T/C ch.11.42038R chr11:967971 AP2A2 0.58 9.99 0.48 1.08e-20 Alzheimer's disease (late onset); CRC cis rs6754311 0.731 rs745500 chr2:136583192 G/A cg25344623 chr2:136566232 LCT 0.32 5.89 0.31 9.71e-9 Mosquito bite size; CRC cis rs9494145 0.680 rs9376092 chr6:135427144 A/C cg22676075 chr6:135203613 NA -0.5 -6.46 -0.34 3.71e-10 Mean platelet volume;Platelet count;Fetal hemoglobin levels in sickle cell anemia;Red blood cell traits; CRC cis rs1799949 0.965 rs35954893 chr17:41333786 A/G cg19454999 chr17:41278357 BRCA1;NBR2 0.55 8.66 0.43 2.12e-16 Menopause (age at onset); CRC cis rs6964587 0.967 rs10279210 chr7:91616891 G/A cg17063962 chr7:91808500 NA 0.83 14.93 0.64 7.87e-39 Breast cancer; CRC cis rs2302190 0.882 rs11650710 chr17:56583547 C/T cg12560992 chr17:57184187 TRIM37 0.52 6.06 0.32 3.67e-9 Vitamin D levels; CRC cis rs6499255 1.000 rs4497676 chr16:69814950 G/A cg00738113 chr16:70207722 CLEC18C -0.43 -6.36 -0.33 6.77e-10 IgE levels; CRC cis rs4604732 0.578 rs12036417 chr1:247624805 T/C cg02104434 chr1:247694406 LOC148824;OR2C3 0.6 8.82 0.44 6.67e-17 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CRC cis rs9341808 0.754 rs3805925 chr6:80883833 T/C cg08355045 chr6:80787529 NA 0.43 6.95 0.36 1.94e-11 Sitting height ratio; CRC cis rs1223397 0.702 rs1223400 chr6:13271242 T/C cg07912922 chr6:13274314 PHACTR1 0.51 6.21 0.32 1.62e-9 Blood pressure; CRC cis rs7044106 0.791 rs10985001 chr9:123484232 G/A cg09586646 chr9:123605570 PSMD5;LOC253039 0.63 9.36 0.46 1.25e-18 Hip circumference adjusted for BMI; CRC cis rs8180040 1.000 rs295449 chr3:47375955 G/A cg27129171 chr3:47204927 SETD2 0.56 8.86 0.44 5.26e-17 Colorectal cancer; CRC cis rs10751667 0.961 rs6597951 chr11:991530 C/T ch.11.42038R chr11:967971 AP2A2 0.7 11.68 0.54 1.32e-26 Alzheimer's disease (late onset); CRC cis rs873946 0.586 rs3793684 chr10:134568645 G/A cg27286337 chr10:134555280 INPP5A 0.82 9.97 0.48 1.25e-20 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CRC cis rs12701220 0.655 rs7778968 chr7:1144622 C/G cg26769984 chr7:1090371 C7orf50 0.55 7.5 0.38 6.13e-13 Bronchopulmonary dysplasia; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg17900884 chr1:6296090 ICMT 0.48 7.04 0.36 1.09e-11 Anxiety disorder; CRC cis rs490234 0.841 rs13291593 chr9:128228483 A/G cg14078157 chr9:128172775 NA -0.35 -5.85 -0.31 1.19e-8 Mean arterial pressure; CRC cis rs202629 1 rs202629 chr22:41849975 C/T cg06481639 chr22:41940642 POLR3H 0.48 5.91 0.31 8.75e-9 Cannabis dependence symptom count; CRC cis rs10489525 1.000 rs10489525 chr1:115263685 A/G cg01522456 chr1:115632236 TSPAN2 -0.42 -6.03 -0.32 4.5e-9 Autism; CRC cis rs13315871 1.000 rs13066269 chr3:58449244 T/C cg20936604 chr3:58311152 NA -0.73 -7.25 -0.37 3.06e-12 Cholesterol, total; CRC cis rs9322193 0.887 rs11155662 chr6:149913867 T/G cg13206674 chr6:150067644 NUP43 0.65 9.13 0.45 7.07e-18 Lung cancer; CRC cis rs2404602 0.716 rs12438077 chr15:76863601 T/C cg03037974 chr15:76606532 NA 0.66 11.44 0.53 9.38e-26 Blood metabolite levels; CRC cis rs2565722 0.825 rs1247538 chr6:161252452 G/A cg03159191 chr6:161285451 NA -0.48 -5.81 -0.31 1.46e-8 Blood protein levels; CRC cis rs11971779 0.715 rs7781459 chr7:139093882 A/G cg07862535 chr7:139043722 LUC7L2 0.57 7.35 0.38 1.61e-12 Diisocyanate-induced asthma; CRC cis rs853679 0.517 rs9380061 chr6:28132803 T/C cg15845792 chr6:28175446 NA 1.04 13.89 0.61 7.67e-35 Depression; CRC cis rs9362426 0.708 rs7753821 chr6:88100010 T/C cg08069147 chr6:88032118 GJB7;C6orf162 0.48 6.25 0.33 1.29e-9 Depressive episodes in bipolar disorder; CRC cis rs311392 0.902 rs411371 chr8:55092609 G/A cg06042504 chr8:55087323 NA -0.44 -6.82 -0.35 4.41e-11 Pelvic organ prolapse (moderate/severe); CRC cis rs801193 0.569 rs2659907 chr7:66164032 G/A cg18252515 chr7:66147081 NA -0.42 -5.98 -0.31 5.83e-9 Aortic root size; CRC cis rs9372498 0.536 rs1319988 chr6:118782379 G/A cg07617317 chr6:118971624 C6orf204 0.52 6.4 0.33 5.29e-10 Diastolic blood pressure; CRC cis rs1799949 1.000 rs34059614 chr17:41303071 C/T cg19454999 chr17:41278357 BRCA1;NBR2 0.54 8.28 0.42 3.06e-15 Menopause (age at onset); CRC cis rs10901296 0.702 rs11244178 chr9:133766008 C/T cg01000188 chr9:133769184 QRFP -0.68 -8.47 -0.42 8.46e-16 Bilirubin levels; CRC trans rs7267979 1.000 rs2259928 chr20:25281834 G/C cg17903999 chr18:56338584 MALT1 -0.42 -6.99 -0.36 1.52e-11 Liver enzyme levels (alkaline phosphatase); CRC trans rs3960554 0.599 rs56090527 chr7:75762125 A/C cg19862616 chr7:65841803 NCRNA00174 0.75 9.12 0.45 7.51e-18 Eotaxin levels; CRC cis rs6951245 0.935 rs11763765 chr7:1060510 C/T cg24642844 chr7:1081250 C7orf50 -0.77 -9.21 -0.45 4.06e-18 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs7917772 0.507 rs2778036 chr10:104485725 G/A cg11453585 chr10:104263688 ACTR1A;SUFU 0.73 10.09 0.49 4.78e-21 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC cis rs11098499 0.954 rs34858317 chr4:120387110 A/C cg24375607 chr4:120327624 NA 0.5 7.72 0.39 1.4e-13 Corneal astigmatism; CRC cis rs7113874 0.569 rs2871753 chr11:8486650 A/T cg20771178 chr11:8615675 STK33 0.34 5.67 0.3 3.07e-8 Body mass index in physically active individuals;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs2228479 1.000 rs12596492 chr16:89957169 T/G cg12064134 chr16:90016061 DEF8 -0.69 -6.14 -0.32 2.38e-9 Skin colour saturation; CRC trans rs4308415 0.781 rs13102903 chr4:67810734 A/G cg19648955 chr2:177134095 MTX2 -0.41 -6.12 -0.32 2.7e-9 Educational attainment (years of education); CRC trans rs875971 0.545 rs1796222 chr7:66057154 T/C cg02869306 chr7:64672164 INTS4L1 0.44 6.29 0.33 1.03e-9 Aortic root size; CRC cis rs854572 1.000 rs854572 chr7:94954696 C/G cg21856205 chr7:94953877 PON1 -0.76 -13.99 -0.61 3.16e-35 Paraoxonase activity; CRC cis rs2243480 1.000 rs2462569 chr7:65474846 C/T cg12463550 chr7:65579703 CRCP -0.6 -5.81 -0.31 1.45e-8 Diabetic kidney disease; CRC cis rs1008375 0.897 rs3733577 chr4:17649233 T/G cg02297831 chr4:17616191 MED28 0.47 6.31 0.33 9.26e-10 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs4843747 0.671 rs13334603 chr16:88116016 T/C cg03395651 chr16:88107091 BANP 0.57 7.38 0.38 1.28e-12 Menopause (age at onset); CRC cis rs2019137 0.560 rs11123172 chr2:113984303 C/T cg21550016 chr2:113992930 PAX8;LOC440839;LOC654433 -0.66 -10.2 -0.49 2.01e-21 Lymphocyte counts; CRC cis rs6952808 0.792 rs11771973 chr7:1950440 C/G cg00106254 chr7:1943704 MAD1L1 -0.51 -7.5 -0.38 6.15e-13 Bipolar disorder and schizophrenia; CRC cis rs7605827 0.897 rs6745621 chr2:15537866 C/A cg19274914 chr2:15703543 NA 0.39 5.93 0.31 7.85e-9 Educational attainment (years of education); CRC cis rs9322193 0.923 rs2185352 chr6:150035776 T/G cg00933542 chr6:150070202 PCMT1 0.31 6.38 0.33 6.16e-10 Lung cancer; CRC cis rs4076764 1.000 rs7525643 chr1:163426283 G/A cg24596788 chr1:163392923 NA -0.64 -10.09 -0.49 4.89e-21 Motion sickness; CRC cis rs4722166 0.532 rs4719711 chr7:22755688 A/G cg05472934 chr7:22766657 IL6 -0.64 -10.15 -0.49 2.98e-21 Lung cancer; CRC cis rs72781680 1.000 rs72781634 chr2:24199102 C/T cg08917208 chr2:24149416 ATAD2B 0.91 9.28 0.46 2.29e-18 Lymphocyte counts; CRC cis rs9611565 0.659 rs17367716 chr22:41913844 A/G cg03806693 chr22:41940476 POLR3H -1.12 -14.87 -0.63 1.3e-38 Vitiligo; CRC cis rs977987 0.872 rs1559339 chr16:75318646 A/G cg03315344 chr16:75512273 CHST6 0.51 8.72 0.43 1.39e-16 Dupuytren's disease; CRC cis rs1008375 0.966 rs2872957 chr4:17651757 C/A cg02297831 chr4:17616191 MED28 0.5 6.71 0.35 8.74e-11 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs728616 0.867 rs12411407 chr10:81828231 C/T cg11900509 chr10:81946545 ANXA11 -0.52 -5.7 -0.3 2.73e-8 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs727505 0.607 rs67680878 chr7:124787381 G/A cg23710748 chr7:124431027 NA -0.64 -10.24 -0.49 1.56e-21 Lewy body disease; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg26355472 chr1:47134199 ATPAF1 0.44 6.24 0.33 1.34e-9 Response to antipsychotic treatment; CRC cis rs10504229 1.000 rs73607871 chr8:58173007 T/C cg24829409 chr8:58192753 C8orf71 -0.68 -11.34 -0.53 2.27e-25 Developmental language disorder (linguistic errors); CRC cis rs1568889 1.000 rs34667360 chr11:28055650 T/G cg06544937 chr11:28130018 METT5D1;KIF18A 0.76 9.78 0.47 5.38e-20 Bipolar disorder; CRC cis rs3741798 1.000 rs73277486 chr12:12494761 T/C cg08615371 chr12:12503544 MANSC1 1.02 9.22 0.45 3.75e-18 Cerebrospinal fluid biomarker levels; CRC cis rs60871478 0.898 rs4725241 chr7:796883 C/T cg05535760 chr7:792225 HEATR2 0.78 10.35 0.5 6.49e-22 Cerebrospinal P-tau181p levels; CRC cis rs7914558 0.932 rs4307650 chr10:104959852 C/A cg15744005 chr10:104629667 AS3MT -0.33 -6.85 -0.35 3.66e-11 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs2019137 0.560 rs10175462 chr2:113988492 G/A cg11763394 chr2:113992921 PAX8;LOC440839;LOC654433 0.63 9.86 0.48 2.98e-20 Lymphocyte counts; CRC cis rs9916302 0.706 rs667239 chr17:37442241 A/G cg00129232 chr17:37814104 STARD3 0.56 7.16 0.37 5.19e-12 Glomerular filtration rate (creatinine); CRC cis rs11626933 0.959 rs2149649 chr14:90774974 A/G cg14092571 chr14:90743983 NA 0.82 14.19 0.62 5.28e-36 Gut microbiota (bacterial taxa); CRC cis rs41005 1.000 rs41007 chr2:8109043 A/G cg03155496 chr2:8117019 LOC339788 -0.41 -7.54 -0.38 4.74e-13 Response to anti-TNF therapy in rheumatoid arthritis; CRC cis rs9868809 0.656 rs13324119 chr3:48710606 G/C cg00383909 chr3:49044727 WDR6 0.73 7.28 0.37 2.54e-12 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; CRC trans rs9650657 0.504 rs10109167 chr8:11033525 C/T cg06636001 chr8:8085503 FLJ10661 -0.54 -8.57 -0.43 4.22e-16 Neuroticism; CRC cis rs7618501 0.601 rs2624825 chr3:50154989 G/A cg24308560 chr3:49941425 MST1R 0.54 9.05 0.45 1.28e-17 Intelligence (multi-trait analysis); CRC cis rs7412746 0.658 rs3768016 chr1:150809919 T/C cg15448220 chr1:150897856 SETDB1 0.56 8.02 0.4 1.93e-14 Melanoma; CRC cis rs9814567 1.000 rs4309773 chr3:134277301 G/A cg06541857 chr3:134203789 ANAPC13;CEP63 -0.41 -6.14 -0.32 2.42e-9 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs1448094 0.511 rs17279261 chr12:86162714 C/T cg00310523 chr12:86230176 RASSF9 0.41 6.52 0.34 2.71e-10 Major depressive disorder; CRC cis rs853679 0.567 rs1005126 chr6:28367623 C/G cg21251018 chr6:28226885 NKAPL 0.4 5.65 0.3 3.45e-8 Depression; CRC cis rs1552244 0.572 rs6785976 chr3:10168647 A/G cg02579736 chr3:10068473 FANCD2;CIDECP 1.02 11.93 0.55 1.7e-27 Alzheimer's disease; CRC trans rs2797160 1.000 rs1612249 chr6:126014916 C/A cg05039488 chr6:79577232 IRAK1BP1 0.51 7.59 0.39 3.37e-13 Endometrial cancer; CRC cis rs3026101 0.671 rs8076560 chr17:5299527 G/A cg25236894 chr17:5323110 RPAIN;NUP88 0.42 6.9 0.36 2.71e-11 Body mass index; CRC cis rs10504229 0.775 rs72650869 chr8:58157923 T/A cg22535103 chr8:58192502 C8orf71 -0.7 -8.43 -0.42 1.07e-15 Developmental language disorder (linguistic errors); CRC cis rs11864453 0.713 rs12708927 chr16:72126165 C/T cg01557791 chr16:72042693 DHODH -0.44 -6.14 -0.32 2.36e-9 Fibrinogen levels; CRC cis rs1865760 1.000 rs3799372 chr6:25922311 A/G cg16482183 chr6:26056742 HIST1H1C 0.55 7.96 0.4 2.84e-14 Height; CRC cis rs6964587 0.620 rs7808587 chr7:91620096 G/A cg17063962 chr7:91808500 NA 0.62 10.03 0.48 7.92e-21 Breast cancer; CRC cis rs916888 0.773 rs199445 chr17:44817408 C/T cg17911788 chr17:44343683 NA -0.61 -7.06 -0.36 9.97e-12 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs2739330 0.828 rs5760107 chr22:24252597 T/C cg18538332 chr22:24372958 LOC391322 -0.72 -11.31 -0.53 2.73e-25 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs9914988 0.832 rs4795462 chr17:27130991 C/T cg07195577 chr17:27052828 TLCD1 0.42 6.02 0.32 4.64e-9 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg14373490 chr9:74979895 ZFAND5 0.45 6.15 0.32 2.18e-9 Anxiety disorder; CRC cis rs992157 0.710 rs12694432 chr2:219082330 A/G cg00012203 chr2:219082015 ARPC2 0.62 10.45 0.5 2.98e-22 Colorectal cancer; CRC cis rs9303401 0.659 rs12602808 chr17:56698420 A/G cg10487724 chr17:56770010 TEX14;RAD51C 0.78 9.69 0.47 1.07e-19 Cognitive test performance; CRC cis rs236352 0.538 rs9470426 chr6:36846988 T/C cg10099585 chr6:36853529 C6orf89 -0.45 -6.41 -0.33 5.16e-10 Heart rate; CRC cis rs7412746 0.553 rs59337856 chr1:150746406 G/T cg10589385 chr1:150898437 SETDB1 0.3 6.08 0.32 3.34e-9 Melanoma; CRC cis rs977987 0.742 rs12928898 chr16:75462081 G/A cg03315344 chr16:75512273 CHST6 0.55 9.25 0.45 3.01e-18 Dupuytren's disease; CRC cis rs3785574 0.962 rs2584621 chr17:61912436 G/A cg06873352 chr17:61820015 STRADA 0.49 7.73 0.39 1.28e-13 Height; CRC trans rs11098499 0.909 rs10002083 chr4:120311152 C/T cg25214090 chr10:38739885 LOC399744 0.62 9.74 0.47 7.35e-20 Corneal astigmatism; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg06818627 chr12:109536430 UNG 0.48 6.16 0.32 2.12e-9 Thyroid stimulating hormone; CRC cis rs7849270 1.000 rs1571229 chr9:131913711 A/G cg13538475 chr9:131942899 NA -0.29 -5.75 -0.3 2e-8 Blood metabolite ratios; CRC cis rs7809950 1.000 rs2066735 chr7:107188719 G/T cg23024343 chr7:107201750 COG5 -0.61 -8.58 -0.43 3.91e-16 Coronary artery disease; CRC cis rs1799949 1.000 rs35668327 chr17:41273095 G/A cg19454999 chr17:41278357 BRCA1;NBR2 0.54 8.58 0.43 3.69e-16 Menopause (age at onset); CRC cis rs4561483 0.603 rs11075033 chr16:12006338 C/T cg08843971 chr16:11963173 GSPT1 0.5 7.46 0.38 7.59e-13 Testicular germ cell tumor; CRC cis rs7772486 0.654 rs6928007 chr6:146074941 G/A cg13319975 chr6:146136371 FBXO30 0.44 6.55 0.34 2.2e-10 Lobe attachment (rater-scored or self-reported); CRC trans rs10506458 0.915 rs1463821 chr12:63402875 C/G cg22491629 chr6:157744540 C6orf35 0.72 8.9 0.44 3.89e-17 Hemostatic factors and hematological phenotypes; CRC cis rs6963495 0.818 rs17343556 chr7:105151272 C/T cg02135003 chr7:105160482 PUS7 -0.9 -12.16 -0.56 2.37e-28 Bipolar disorder (body mass index interaction); CRC cis rs317689 0.690 rs618470 chr12:69672060 A/G cg20891283 chr12:69753455 YEATS4 0.44 5.79 0.3 1.64e-8 Response to diuretic therapy; CRC cis rs2404602 0.709 rs11072597 chr15:76763514 C/A cg03037974 chr15:76606532 NA -0.52 -7.5 -0.38 5.99e-13 Blood metabolite levels; CRC cis rs863345 0.584 rs6427438 chr1:158454730 C/T cg12129480 chr1:158549410 OR10X1 -0.29 -6.05 -0.32 3.87e-9 Pneumococcal bacteremia; CRC cis rs9393692 0.557 rs62394768 chr6:26326033 C/T cg13736514 chr6:26305472 NA -0.45 -7.3 -0.37 2.12e-12 Educational attainment; CRC cis rs2075371 0.933 rs431306 chr7:133955974 A/T cg11752832 chr7:134001865 SLC35B4 0.44 6.63 0.34 1.41e-10 Mean platelet volume; CRC cis rs17539620 0.519 rs12665532 chr6:154835182 C/G cg20019720 chr6:154832845 CNKSR3 0.54 10.64 0.51 6.38e-23 Lipoprotein (a) levels; CRC cis rs12523822 0.957 rs55737042 chr6:154955676 T/C cg20019720 chr6:154832845 CNKSR3 0.26 5.61 0.3 4.23e-8 Diabetic kidney disease; CRC cis rs4563143 0.514 rs73029079 chr19:29294903 A/G cg03161606 chr19:29218774 NA 0.54 6.26 0.33 1.21e-9 Methadone dose in opioid dependence; CRC cis rs9768139 0.708 rs10233815 chr7:158114348 C/T cg06219351 chr7:158114137 PTPRN2 -0.6 -9.53 -0.47 3.61e-19 Calcium levels; CRC trans rs4263408 0.934 rs9683743 chr4:39703194 A/C cg16166399 chr19:59030753 ZBTB45 -0.43 -6.36 -0.33 6.8e-10 Plasma amyloid beta peptide concentrations (ABx-40); CRC cis rs2404602 0.647 rs12439141 chr15:77095423 T/C cg03037974 chr15:76606532 NA -0.51 -7.29 -0.37 2.3e-12 Blood metabolite levels; CRC cis rs4713118 0.869 rs9468214 chr6:27713299 G/C cg19041857 chr6:27730383 NA -0.42 -6.03 -0.32 4.3e-9 Parkinson's disease; CRC cis rs9858213 1 rs9858213 chr3:49731861 G/T cg07274523 chr3:49395745 GPX1 0.49 6.19 0.32 1.8e-9 Educational attainment; CRC trans rs9858542 0.953 rs6809216 chr3:49412559 G/A cg21665057 chr3:196295764 WDR53;FBXO45 -0.64 -8.75 -0.43 1.1e-16 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC trans rs1376359 0.587 rs55954802 chr1:103121812 G/A cg16220183 chr17:56609687 SEPT4 -0.46 -6.27 -0.33 1.15e-9 QRS duration in Tripanosoma cruzi seropositivity; CRC cis rs1046896 0.553 rs72634343 chr17:80827392 T/C cg08200770 chr17:80723486 TBCD -0.48 -7.35 -0.38 1.59e-12 Glycated hemoglobin levels; CRC cis rs921968 0.573 rs684776 chr2:219324016 T/C cg02176678 chr2:219576539 TTLL4 0.54 8.69 0.43 1.78e-16 Mean corpuscular hemoglobin concentration; CRC cis rs60843830 1.000 rs55946380 chr2:268293 A/G cg25945732 chr2:264204 ACP1;SH3YL1 0.71 11.67 0.54 1.46e-26 Spherical equivalent (joint analysis main effects and education interaction); CRC cis rs877282 0.853 rs11253332 chr10:755262 G/C cg17470449 chr10:769945 NA 0.61 7.96 0.4 2.78e-14 Uric acid levels; CRC trans rs2727020 0.553 rs11040400 chr11:49518296 C/A cg03929089 chr4:120376271 NA -0.91 -16.61 -0.68 1.93e-45 Coronary artery disease; CRC cis rs28386778 0.897 rs6504184 chr17:61842408 A/T cg25654072 chr17:61904446 PSMC5;FTSJ3 0.73 11.3 0.53 2.96e-25 Prudent dietary pattern; CRC cis rs35995292 0.500 rs6945239 chr7:38932208 C/T cg19327137 chr7:38886074 VPS41 0.62 10.19 0.49 2.31e-21 Subjective well-being (multi-trait analysis); CRC cis rs13108904 0.901 rs1316393 chr4:1315619 A/G cg00684032 chr4:1343700 KIAA1530 -0.49 -7.41 -0.38 1.06e-12 Obesity-related traits; CRC cis rs3806843 0.966 rs2563262 chr5:140137712 C/G cg19875535 chr5:140030758 IK -0.55 -8.8 -0.44 7.81e-17 Depressive symptoms (multi-trait analysis); CRC cis rs13108904 0.846 rs4974574 chr4:1224811 A/G cg16405210 chr4:1374714 KIAA1530 -0.41 -5.8 -0.3 1.59e-8 Obesity-related traits; CRC cis rs10971721 0.822 rs10971753 chr9:33870436 C/T cg13495928 chr9:33750294 PRSS3 0.56 5.95 0.31 6.96e-9 Body mass index; CRC cis rs9649213 0.593 rs34776142 chr7:97899873 C/T cg00277769 chr7:97922759 BAIAP2L1 -0.61 -10.5 -0.5 1.99e-22 Prostate cancer (SNP x SNP interaction); CRC cis rs6502050 0.835 rs4789672 chr17:80126603 T/C cg02741985 chr17:80059408 CCDC57 0.44 7.3 0.37 2.15e-12 Life satisfaction; CRC cis rs3026101 0.624 rs1058400 chr17:5288794 G/C cg25236894 chr17:5323110 RPAIN;NUP88 0.4 6.63 0.34 1.38e-10 Body mass index; CRC cis rs2282802 0.660 rs6873248 chr5:139683762 A/G cg26211634 chr5:139558579 C5orf32 -0.44 -7.75 -0.39 1.18e-13 Intelligence (multi-trait analysis); CRC cis rs12142240 0.698 rs66483119 chr1:46838389 T/C cg14993813 chr1:46806288 NSUN4 -0.48 -6.05 -0.32 3.98e-9 Menopause (age at onset); CRC trans rs17270561 0.887 rs12201170 chr6:25866247 A/G cg21589273 chr3:113416452 KIAA2018 0.53 5.96 0.31 6.34e-9 Iron status biomarkers; CRC cis rs72781680 0.898 rs72786279 chr2:24063266 C/T cg08917208 chr2:24149416 ATAD2B 0.93 9.53 0.47 3.63e-19 Lymphocyte counts; CRC cis rs10504229 0.683 rs7463453 chr8:58112053 A/G cg22535103 chr8:58192502 C8orf71 -0.7 -9.2 -0.45 4.33e-18 Developmental language disorder (linguistic errors); CRC cis rs2739330 0.760 rs1002286 chr22:24257337 A/G cg11905131 chr22:24372483 LOC391322 0.67 10.73 0.51 3.24e-23 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs1552244 0.572 rs67439440 chr3:10169503 C/T cg16606324 chr3:10149918 C3orf24 0.66 7.77 0.39 9.99e-14 Alzheimer's disease; CRC cis rs9733 0.596 rs6669369 chr1:150695892 C/T cg18016565 chr1:150552671 MCL1 0.45 6.52 0.34 2.57e-10 Tonsillectomy; CRC cis rs35306767 0.761 rs11253557 chr10:1043667 C/T cg26597838 chr10:835615 NA 0.95 11.22 0.53 5.91e-25 Eosinophil percentage of granulocytes; CRC cis rs1018836 0.886 rs10956750 chr8:91621704 G/C cg16814680 chr8:91681699 NA -0.76 -11.96 -0.55 1.31e-27 Ejection fraction in Tripanosoma cruzi seropositivity; CRC cis rs7618915 0.571 rs6805539 chr3:52609710 T/A cg15147215 chr3:52552868 STAB1 -0.63 -10.51 -0.5 1.83e-22 Bipolar disorder; CRC cis rs9486719 0.802 rs2983896 chr6:97029871 G/A cg06623918 chr6:96969491 KIAA0776 -0.83 -11.75 -0.54 7.4e-27 Migraine;Coronary artery disease; CRC cis rs2629540 0.765 rs12221075 chr10:126534855 G/A cg08799069 chr10:126477246 METTL10 -0.5 -7.21 -0.37 3.83e-12 Cocaine dependence; CRC cis rs597539 0.652 rs686877 chr11:68637169 G/A cg06028808 chr11:68637592 NA 0.41 6.67 0.35 1.07e-10 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs7264396 0.635 rs6060710 chr20:34536055 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.63 -10.26 -0.49 1.33e-21 Total cholesterol levels; CRC cis rs4742903 0.967 rs10125661 chr9:106868443 A/G cg21169611 chr9:106856078 SMC2 0.41 5.75 0.3 2.08e-8 High-grade serous ovarian cancer;Breast cancer; CRC cis rs8031584 0.918 rs61997138 chr15:31270776 C/T cg08704250 chr15:31115839 NA -0.44 -8.17 -0.41 6.74e-15 Huntington's disease progression; CRC trans rs45509595 0.841 rs200501 chr6:27788942 C/T cg06606381 chr12:133084897 FBRSL1 -0.78 -6.64 -0.34 1.26e-10 Breast cancer; CRC cis rs7586879 0.639 rs6713978 chr2:25120851 T/C cg22495460 chr2:25135724 ADCY3 -0.87 -17.11 -0.69 2.25e-47 Body mass index; CRC cis rs12701220 0.553 rs13245507 chr7:1163694 C/T cg26769984 chr7:1090371 C7orf50 0.48 6.36 0.33 6.61e-10 Bronchopulmonary dysplasia; CRC cis rs1153858 1.000 rs1890565 chr15:45663299 T/C cg21132104 chr15:45694354 SPATA5L1 0.6 8.89 0.44 3.98e-17 Homoarginine levels; CRC cis rs6951245 1.000 rs11763793 chr7:1094342 A/G cg24642844 chr7:1081250 C7orf50 -0.78 -9.46 -0.46 6.12e-19 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC trans rs10982213 0.830 rs2274163 chr9:117188714 C/T cg16642045 chr4:155471719 PLRG1 0.41 6.01 0.31 5.03e-9 Interleukin-6 levels; CRC cis rs736801 0.808 rs6866614 chr5:131787137 A/G cg14196790 chr5:131705035 SLC22A5 -0.35 -5.69 -0.3 2.8e-8 Breast cancer;Mosquito bite size; CRC cis rs2976388 0.609 rs2585153 chr8:143785345 G/A cg22687807 chr8:143858763 LYNX1 0.51 9.05 0.45 1.24e-17 Urinary tract infection frequency; CRC cis rs1865760 0.532 rs2006736 chr6:26086017 C/T cg16482183 chr6:26056742 HIST1H1C 0.52 7.58 0.39 3.66e-13 Height; CRC cis rs897984 0.571 rs7184567 chr16:31021078 C/T cg00531865 chr16:30841666 NA -0.47 -6.68 -0.35 9.91e-11 Dementia with Lewy bodies; CRC cis rs9322193 0.923 rs56397000 chr6:150060483 C/T cg04369109 chr6:150039330 LATS1 -0.42 -5.79 -0.3 1.6e-8 Lung cancer; CRC cis rs9914988 0.943 rs12951232 chr17:27132638 G/C cg07195577 chr17:27052828 TLCD1 0.42 6.02 0.32 4.64e-9 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs747650 0.504 rs10838646 chr11:47036794 G/C cg19486271 chr11:47235900 DDB2 -0.44 -5.88 -0.31 1.03e-8 Acne (severe); CRC cis rs9660180 0.846 rs10907195 chr1:1713348 C/T cg17747265 chr1:1875780 NA 0.63 10.27 0.49 1.24e-21 Body mass index; CRC cis rs4750440 0.523 rs4565801 chr10:14032358 G/A cg00551146 chr10:14014579 FRMD4A 0.45 7.33 0.37 1.85e-12 Adiponectin levels; CRC cis rs875971 0.862 rs1860469 chr7:66106875 A/G cg18876405 chr7:65276391 NA -0.53 -8.59 -0.43 3.64e-16 Aortic root size; CRC cis rs4665809 0.590 rs1469523 chr2:26474631 T/A cg25036284 chr2:26402008 FAM59B 0.62 7.86 0.4 5.64e-14 Gut microbiome composition (summer); CRC cis rs1448094 0.512 rs11117057 chr12:86248546 C/T cg18827107 chr12:86230957 RASSF9 -0.45 -7.49 -0.38 6.6e-13 Major depressive disorder; CRC trans rs8002861 0.875 rs12872943 chr13:44410553 G/A cg12856521 chr11:46389249 DGKZ -0.43 -6.84 -0.35 3.8e-11 Leprosy; CRC cis rs1153858 1.000 rs11852800 chr15:45639131 A/G cg21132104 chr15:45694354 SPATA5L1 -0.55 -8.19 -0.41 5.71e-15 Homoarginine levels; CRC trans rs1908814 0.516 rs56102998 chr8:11796675 G/A cg08975724 chr8:8085496 FLJ10661 0.4 6.0 0.31 5.24e-9 Neuroticism; CRC cis rs9487051 0.708 rs378447 chr6:109526823 G/A cg21918786 chr6:109611834 NA -0.35 -5.95 -0.31 6.83e-9 Reticulocyte fraction of red cells; CRC cis rs9467711 0.659 rs72844462 chr6:26563864 A/C cg16898833 chr6:26189333 HIST1H4D 1.14 8.46 0.42 8.89e-16 Autism spectrum disorder or schizophrenia; CRC cis rs68170813 0.559 rs80153759 chr7:106944145 C/A cg02696742 chr7:106810147 HBP1 -0.59 -6.6 -0.34 1.66e-10 Coronary artery disease; CRC cis rs2070677 1.000 rs1410897 chr10:135349537 G/A cg20169779 chr10:135381914 SYCE1 0.78 11.25 0.53 4.74e-25 Gout; CRC cis rs7113874 0.569 rs10840077 chr11:8601210 A/T cg17679104 chr11:8615758 STK33 0.36 6.03 0.32 4.44e-9 Body mass index in physically active individuals;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs11098499 0.554 rs2175381 chr4:120265967 T/C cg24375607 chr4:120327624 NA 0.47 7.68 0.39 1.89e-13 Corneal astigmatism; CRC cis rs7772486 0.875 rs13198450 chr6:146370524 C/A cg05347473 chr6:146136440 FBXO30 0.36 5.67 0.3 3.15e-8 Lobe attachment (rater-scored or self-reported); CRC cis rs9910055 0.683 rs7220138 chr17:42254011 C/G cg19774624 chr17:42201019 HDAC5 -0.72 -11.72 -0.54 9.19e-27 Total body bone mineral density; CRC cis rs7635838 0.587 rs347591 chr3:11290122 G/T cg00170343 chr3:11313890 ATG7 0.58 9.12 0.45 7.5e-18 HDL cholesterol; CRC cis rs123509 0.874 rs339683 chr3:42788511 G/T cg12982090 chr3:42733453 KBTBD5 0.54 6.99 0.36 1.52e-11 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs7998202 0.667 rs695163 chr13:113363300 G/A cg02820901 chr13:113351484 ATP11A 0.6 6.65 0.34 1.23e-10 Glycated hemoglobin levels; CRC cis rs1218582 0.745 rs1580943 chr1:154865125 G/A cg09359103 chr1:154839909 KCNN3 -0.74 -13.15 -0.59 5.08e-32 Prostate cancer; CRC cis rs6867032 0.527 rs13190594 chr5:2012474 T/C cg26168224 chr5:2018326 NA 0.8 13.53 0.6 1.79e-33 Gut microbiome composition (winter); CRC cis rs6665290 0.904 rs1045290 chr1:227178700 A/G cg10327440 chr1:227177885 CDC42BPA -1.04 -23.9 -0.8 7.05e-74 Myeloid white cell count; CRC cis rs1949733 0.598 rs16842480 chr4:8535621 G/T cg11789530 chr4:8429930 ACOX3 -0.57 -7.94 -0.4 3.17e-14 Response to antineoplastic agents; CRC cis rs10504229 0.636 rs77290284 chr8:58055269 G/T cg21724239 chr8:58056113 NA 0.72 8.73 0.43 1.31e-16 Developmental language disorder (linguistic errors); CRC cis rs12477438 0.501 rs6542868 chr2:99782848 A/C cg14399236 chr2:99771627 LIPT1;TSGA10 0.73 12.17 0.56 2.24e-28 Chronic sinus infection; CRC cis rs6860806 0.507 rs272854 chr5:131688017 C/T cg12564285 chr5:131593104 PDLIM4 0.45 7.59 0.39 3.28e-13 Breast cancer; CRC cis rs9443645 0.509 rs9352668 chr6:79572678 A/G cg05283184 chr6:79620031 NA -0.47 -6.9 -0.36 2.66e-11 Intelligence (multi-trait analysis); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg06824242 chr15:38746275 FAM98B 0.44 6.08 0.32 3.4e-9 Response to antipsychotic treatment; CRC cis rs3768617 0.510 rs4491025 chr1:183065183 C/T ch.1.3577855R chr1:183094577 LAMC1 0.86 15.19 0.64 7.31e-40 Fuchs's corneal dystrophy; CRC cis rs7586673 0.964 rs34444368 chr2:161954217 G/A cg22496339 chr2:162101262 NA 0.62 8.61 0.43 3.07e-16 Intelligence (multi-trait analysis); CRC cis rs6504950 0.830 rs1802212 chr17:53038654 A/C cg26251398 chr17:52985966 TOM1L1 0.42 5.62 0.3 4.01e-8 Breast cancer; CRC cis rs4423214 1.000 rs12790010 chr11:71170653 T/C cg05163923 chr11:71159392 DHCR7 0.66 9.28 0.46 2.32e-18 Vitamin D levels; CRC cis rs2952156 0.920 rs2934956 chr17:37830447 T/A cg00129232 chr17:37814104 STARD3 -0.71 -12.56 -0.57 7.71e-30 Asthma; CRC cis rs651907 0.557 rs11925001 chr3:101373966 C/T cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.62 8.41 0.42 1.3e-15 Colorectal cancer; CRC cis rs4713118 0.662 rs9380045 chr6:28025279 A/G cg21251018 chr6:28226885 NKAPL 0.46 6.46 0.34 3.67e-10 Parkinson's disease; CRC cis rs7917772 0.560 rs35095897 chr10:104377759 T/C cg11453585 chr10:104263688 ACTR1A;SUFU -0.81 -14.52 -0.62 2.9e-37 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC cis rs1950626 0.705 rs34991312 chr14:101435167 A/C cg02351406 chr14:101447389 SNORD114-20;SNORD114-21 0.96 15.57 0.65 2.37e-41 Pelvic organ prolapse (moderate/severe); CRC cis rs12142240 0.698 rs17361833 chr1:46828700 A/G cg14993813 chr1:46806288 NSUN4 -0.49 -6.26 -0.33 1.21e-9 Menopause (age at onset); CRC cis rs9309473 0.528 rs10191517 chr2:73558403 G/A cg20560298 chr2:73613845 ALMS1 -0.44 -5.95 -0.31 7.02e-9 Metabolite levels; CRC cis rs11722228 1.000 rs11722228 chr4:9915741 C/T cg00071950 chr4:10020882 SLC2A9 0.46 6.97 0.36 1.71e-11 Gout;Urate levels;Serum uric acid levels; CRC cis rs7618915 0.524 rs2028216 chr3:52680823 C/T cg18404041 chr3:52824283 ITIH1 -0.44 -9.03 -0.45 1.49e-17 Bipolar disorder; CRC trans rs9784649 0.771 rs72755810 chr5:25039139 A/C cg11038491 chr20:34638489 LOC647979 -0.58 -7.52 -0.38 5.34e-13 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs6477694 1.000 rs6477694 chr9:111932342 C/T cg14171727 chr9:111936775 EPB41L4B -0.38 -6.08 -0.32 3.39e-9 Body mass index; CRC cis rs2404602 1.000 rs12148786 chr15:76800362 A/G cg22467129 chr15:76604101 ETFA -0.38 -6.3 -0.33 9.59e-10 Blood metabolite levels; CRC cis rs6963495 0.818 rs73190158 chr7:105153943 T/C cg13798780 chr7:105162888 PUS7 0.68 8.08 0.41 1.27e-14 Bipolar disorder (body mass index interaction); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg25372841 chr8:145675454 CYHR1 -0.36 -6.08 -0.32 3.36e-9 Liver disease severity in Alagille syndrome; CRC cis rs58804349 0.581 rs12221397 chr10:43239833 A/G cg20628663 chr10:43360327 NA -0.69 -7.22 -0.37 3.56e-12 Pediatric bone mineral content (radius); CRC cis rs853679 0.517 rs9380058 chr6:28127444 T/C cg12172441 chr6:28176163 NA 0.63 7.43 0.38 9.41e-13 Depression; CRC cis rs8180040 0.966 rs56351005 chr3:47430186 G/T cg02527881 chr3:46936655 PTH1R 0.37 6.74 0.35 6.98e-11 Colorectal cancer; CRC cis rs7932354 0.528 rs7108902 chr11:47091571 C/T cg03339077 chr11:47165057 C11orf49 0.43 5.95 0.31 6.94e-9 Bone mineral density (hip);Bone mineral density; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg00561562 chr4:144435738 SMARCA5 0.42 6.04 0.32 4.15e-9 Intelligence (multi-trait analysis); CRC cis rs6988985 0.589 rs6987382 chr8:143987191 G/A cg10324643 chr8:143916377 GML 0.38 6.42 0.33 4.68e-10 Plasma androstenedione levels in resected early stage-receptor positive breast cancer; CRC cis rs7552404 0.924 rs1146579 chr1:76209792 C/T cg22875332 chr1:76189707 ACADM -0.69 -10.36 -0.5 6.07e-22 Blood metabolite levels;Acylcarnitine levels; CRC cis rs9733 0.650 rs11204668 chr1:150543686 G/A cg18016565 chr1:150552671 MCL1 -0.47 -7.14 -0.37 6.02e-12 Tonsillectomy; CRC cis rs738322 0.775 rs13056506 chr22:38580917 G/T cg17652424 chr22:38574118 PLA2G6 0.2 6.13 0.32 2.5e-9 Cutaneous nevi; CRC cis rs10463316 0.862 rs10071166 chr5:150768795 T/C cg03212797 chr5:150827313 SLC36A1 -0.5 -7.92 -0.4 3.8e-14 Metabolite levels (Pyroglutamine); CRC cis rs71718386 1 rs71718386 chr13:41224287 CTATA/C cg21288729 chr13:41239152 FOXO1 0.49 7.62 0.39 2.75e-13 Eosinophil counts; CRC cis rs10504229 0.639 rs2318145 chr8:58114867 A/G cg02725872 chr8:58115012 NA -0.65 -11.61 -0.54 2.34e-26 Developmental language disorder (linguistic errors); CRC cis rs7680126 0.500 rs4697933 chr4:10146493 G/A cg00071950 chr4:10020882 SLC2A9 -0.46 -6.03 -0.32 4.38e-9 Urate levels in lean individuals;Urate levels in overweight individuals;Urate levels in obese individuals; CRC cis rs78456975 0.739 rs11896906 chr2:1519550 A/G cg26248373 chr2:1572462 NA -0.64 -8.13 -0.41 8.85e-15 Placebo response in major depressive disorder (% change in symptom score); CRC cis rs798554 0.660 rs2527692 chr7:2856533 G/A cg13628971 chr7:2884303 GNA12 0.42 6.41 0.33 5.04e-10 Height; CRC cis rs9457247 0.730 rs9459841 chr6:167431949 G/A cg07741184 chr6:167504864 NA 0.37 6.49 0.34 3.17e-10 Crohn's disease; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg23335269 chr10:6130793 RBM17 0.4 6.44 0.33 4.22e-10 Liver disease severity in Alagille syndrome; CRC cis rs1348850 0.874 rs4893822 chr2:178285727 G/T cg22681709 chr2:178499509 PDE11A -0.39 -6.89 -0.36 2.79e-11 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs11190604 1.000 rs11190570 chr10:102227702 G/C cg07570687 chr10:102243282 WNT8B 0.44 5.65 0.3 3.53e-8 Palmitoleic acid (16:1n-7) levels; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg05828906 chr6:126278519 HINT3 0.46 6.43 0.33 4.37e-10 Response to antipsychotic treatment; CRC cis rs826838 0.967 rs1684413 chr12:39128704 G/A cg26384229 chr12:38710491 ALG10B -0.64 -9.67 -0.47 1.21e-19 Heart rate; CRC cis rs6701037 0.512 rs4650716 chr1:175128711 C/A cg17845761 chr1:175162550 KIAA0040 0.31 6.65 0.34 1.22e-10 Alcohol dependence; CRC trans rs61101201 0.962 rs10835790 chr11:31610022 C/T cg07934026 chr4:467794 ZNF721;ABCA11P -0.53 -6.08 -0.32 3.41e-9 Optic disc area; CRC cis rs11711311 1.000 rs9288984 chr3:113525956 A/C cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.53 -7.3 -0.37 2.21e-12 IgG glycosylation; CRC cis rs28386778 0.830 rs2584625 chr17:61903445 G/C cg23090583 chr17:61904693 PSMC5;FTSJ3 1.05 20.27 0.75 7.25e-60 Prudent dietary pattern; CRC trans rs6600671 1.000 rs1591882 chr1:121183313 G/A cg09829573 chr1:144692074 NBPF9 -0.41 -6.17 -0.32 2.01e-9 Hip geometry; CRC cis rs7091068 0.671 rs591392 chr10:95406081 G/A cg20715218 chr10:95462985 C10orf4 -0.47 -5.61 -0.3 4.3e-8 Urinary tract infection frequency; CRC cis rs2795502 0.630 rs2914988 chr10:43509354 A/T cg08461752 chr10:43522343 NA -0.82 -7.64 -0.39 2.45e-13 Blood protein levels; CRC trans rs2055729 0.677 rs13270146 chr8:9740595 C/T cg08975724 chr8:8085496 FLJ10661 -0.44 -6.01 -0.31 4.91e-9 Multiple myeloma (hyperdiploidy); CRC cis rs35306767 0.855 rs11253468 chr10:903261 G/A cg26597838 chr10:835615 NA 0.88 11.01 0.52 3.38e-24 Eosinophil percentage of granulocytes; CRC trans rs561341 0.740 rs11080174 chr17:30208521 C/A cg27661571 chr11:113659931 NA 0.48 6.27 0.33 1.13e-9 Hip circumference adjusted for BMI; CRC cis rs11122272 0.525 rs2749713 chr1:231537921 T/C cg06096015 chr1:231504339 EGLN1 0.42 6.2 0.32 1.69e-9 Hemoglobin concentration; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg10020083 chr5:176873646 PRR7 0.46 6.28 0.33 1.06e-9 Response to antipsychotic treatment; CRC cis rs6831352 0.840 rs17817868 chr4:100060623 C/T cg12011299 chr4:100065546 ADH4 -0.5 -9.49 -0.46 5.01e-19 Alcohol dependence; CRC cis rs6089584 0.816 rs6061411 chr20:60634716 C/A cg18761221 chr20:60518478 NA 0.47 7.67 0.39 2.02e-13 Body mass index; CRC cis rs6951245 1.000 rs79617366 chr7:1111958 G/C cg22907277 chr7:1156413 C7orf50 0.75 7.95 0.4 3.04e-14 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs12220238 1.000 rs10824078 chr10:75892120 C/T cg19889307 chr10:75911429 ADK;AP3M1 0.62 5.85 0.31 1.19e-8 Soluble interleukin-2 receptor subunit alpha; CRC cis rs400736 0.602 rs10864330 chr1:8168564 C/T cg25007680 chr1:8021821 PARK7 -0.51 -6.98 -0.36 1.65e-11 Response to antidepressants and depression; CRC cis rs7945705 0.935 rs2653593 chr11:8877317 G/A cg12365402 chr11:9010492 NRIP3 -0.48 -8.11 -0.41 1.04e-14 Hemoglobin concentration; CRC cis rs5750830 0.649 rs4821895 chr22:39823015 A/G cg25956985 chr22:39795188 MAP3K7IP1 -0.46 -6.9 -0.36 2.73e-11 Intelligence (multi-trait analysis); CRC trans rs61931739 0.534 rs2625897 chr12:34064295 G/A cg26384229 chr12:38710491 ALG10B 0.51 7.01 0.36 1.36e-11 Morning vs. evening chronotype; CRC cis rs13191362 1.000 rs35911566 chr6:162994154 T/C cg23758597 chr6:163146217 PARK2 -0.56 -6.18 -0.32 1.93e-9 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs4660306 0.614 rs11211116 chr1:45930038 A/G cg03123370 chr1:45965343 CCDC163P;MMACHC 0.49 6.5 0.34 3.01e-10 Homocysteine levels; CRC cis rs2739330 0.761 rs5760176 chr22:24402321 A/G cg16132339 chr22:24313637 DDTL;DDT -0.58 -9.44 -0.46 6.96e-19 Liver enzyme levels (gamma-glutamyl transferase); CRC trans rs4618210 0.722 rs1806555 chr3:17016794 G/T cg02134305 chr3:49507478 DAG1 0.49 6.12 0.32 2.68e-9 Myocardial infarction; CRC cis rs7945705 0.902 rs2568059 chr11:8884161 T/C cg14711859 chr11:8959438 ASCL3 0.45 7.53 0.38 4.86e-13 Hemoglobin concentration; CRC cis rs3858526 0.584 rs10769274 chr11:5866925 T/C cg13902645 chr11:5959945 NA -0.66 -9.36 -0.46 1.24e-18 DNA methylation (variation); CRC cis rs7811142 0.943 rs111757992 chr7:100016354 A/C cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.77 10.97 0.52 4.42e-24 Platelet count; CRC cis rs10504229 0.683 rs56192850 chr8:58135356 A/G cg02725872 chr8:58115012 NA -0.64 -11.55 -0.54 3.85e-26 Developmental language disorder (linguistic errors); CRC cis rs875971 0.522 rs34973832 chr7:65396204 A/G cg11764359 chr7:65958608 NA 0.5 7.7 0.39 1.6e-13 Aortic root size; CRC cis rs916888 0.821 rs199506 chr17:44859031 A/G cg15921436 chr17:44337874 NA -0.67 -7.62 -0.39 2.69e-13 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs1878931 0.624 rs27235 chr16:3439138 G/C cg26668626 chr16:3451006 ZNF174;ZNF434 -0.58 -6.93 -0.36 2.19e-11 Body mass index (adult); CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg02838143 chr10:126606107 NA 0.45 5.96 0.31 6.33e-9 Anxiety disorder; CRC cis rs6735179 0.688 rs2382562 chr2:1763509 G/A cg19300414 chr2:1746591 PXDN 0.34 6.11 0.32 2.8e-9 Response to antipsychotic treatment; CRC cis rs743757 1.000 rs2236964 chr3:50449062 C/G cg08207895 chr3:50388901 TUSC4;CYB561D2 -0.44 -6.54 -0.34 2.3e-10 Diastolic blood pressure; CRC cis rs3741404 0.672 rs4980524 chr11:63959259 A/C cg06243084 chr11:63990629 FERMT3 -0.39 -6.08 -0.32 3.26e-9 Platelet count; CRC trans rs1814175 0.647 rs4881649 chr11:49845560 A/G cg03929089 chr4:120376271 NA -0.74 -12.15 -0.56 2.7e-28 Height; CRC cis rs6484504 0.600 rs10835763 chr11:31345574 G/A cg14844989 chr11:31128820 NA 0.34 6.09 0.32 3.19e-9 Red blood cell count; CRC cis rs796364 1.000 rs4410273 chr2:200818258 T/C cg25936922 chr2:200820526 C2orf60;C2orf47 0.74 7.9 0.4 4.31e-14 Schizophrenia; CRC cis rs1448094 0.512 rs11117061 chr12:86250916 G/A cg18827107 chr12:86230957 RASSF9 -0.48 -7.85 -0.4 6.03e-14 Major depressive disorder; CRC cis rs13191362 1.000 rs35449999 chr6:163023465 A/G cg23758597 chr6:163146217 PARK2 -0.55 -5.96 -0.31 6.42e-9 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs11997175 0.583 rs7824990 chr8:33779934 A/G cg04338863 chr8:33670619 NA 0.38 5.79 0.3 1.63e-8 Body mass index; CRC cis rs11677416 1.000 rs1878319 chr2:113544826 G/A cg27083787 chr2:113543245 IL1A 0.42 5.93 0.31 7.84e-9 Response to antipsychotic treatment in schizophrenia (working memory); CRC cis rs11764590 0.715 rs56289396 chr7:2091415 G/A cg21155852 chr7:2048760 MAD1L1 -0.45 -5.88 -0.31 1.03e-8 Neuroticism; CRC trans rs2055729 0.677 rs59880252 chr8:9741032 C/T cg08975724 chr8:8085496 FLJ10661 0.47 6.06 0.32 3.73e-9 Multiple myeloma (hyperdiploidy); CRC cis rs1003719 0.788 rs9974286 chr21:38456832 A/G cg10648535 chr21:38446584 PIGP;TTC3 -0.49 -7.21 -0.37 3.92e-12 Eye color traits; CRC cis rs7959452 0.590 rs10878974 chr12:69781528 C/G cg14784868 chr12:69753453 YEATS4 0.84 14.68 0.63 7.14e-38 Blood protein levels; CRC trans rs1005277 0.579 rs2505257 chr10:38372664 A/G cg23533926 chr12:111358616 MYL2 -0.52 -7.83 -0.4 6.56e-14 Extrinsic epigenetic age acceleration; CRC cis rs394563 0.591 rs11964335 chr6:149658101 A/T cg16235748 chr6:149772707 ZC3H12D 0.35 6.35 0.33 7.03e-10 Dupuytren's disease; CRC cis rs12024301 0.557 rs12077933 chr1:183658222 A/G cg11505048 chr1:183622726 RGL1;APOBEC4 0.71 6.24 0.33 1.33e-9 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs2228479 0.850 rs17233455 chr16:89816407 A/G cg19635926 chr16:89946313 TCF25 0.66 5.97 0.31 6.1e-9 Skin colour saturation; CRC cis rs3820068 0.603 rs7537618 chr1:15977682 G/A cg24675056 chr1:15929824 NA 0.54 7.43 0.38 9.67e-13 Systolic blood pressure; CRC cis rs12190007 0.547 rs3006182 chr6:169808323 C/T cg15038512 chr6:170123185 PHF10 -0.39 -6.05 -0.32 3.86e-9 Obesity-related traits; CRC cis rs6502050 0.799 rs8069827 chr17:80089168 C/T cg22110888 chr17:80059540 CCDC57 0.4 6.34 0.33 7.4e-10 Life satisfaction; CRC cis rs28493229 0.582 rs78915350 chr19:41160609 A/G cg21869046 chr19:41225005 ITPKC 0.41 6.19 0.32 1.81e-9 Kawasaki disease; CRC cis rs2243480 1.000 rs7787230 chr7:65629099 G/A cg18252515 chr7:66147081 NA 1.23 14.38 0.62 9.77e-37 Diabetic kidney disease; CRC cis rs3026101 0.578 rs59605950 chr17:5303493 A/G cg25236894 chr17:5323110 RPAIN;NUP88 0.42 6.9 0.36 2.74e-11 Body mass index; CRC cis rs12594515 0.967 rs8039088 chr15:45990178 T/C cg06207120 chr15:45996521 NA 0.32 7.75 0.39 1.14e-13 Waist circumference;Weight; CRC trans rs596169 0.541 rs73111535 chr1:219222850 C/A cg00778190 chr1:95068029 NA 0.74 6.47 0.34 3.63e-10 Intraocular pressure; CRC cis rs7618915 0.571 rs34115864 chr3:52612178 A/G cg07507251 chr3:52567010 NT5DC2 0.46 6.73 0.35 7.48e-11 Bipolar disorder; CRC cis rs1682361 1 rs1682361 chr3:136734014 G/C cg12473912 chr3:136751656 NA 0.4 6.53 0.34 2.56e-10 Schizophrenia; CRC cis rs7617480 0.519 rs6790914 chr3:49206318 G/C cg06212747 chr3:49208901 KLHDC8B 0.44 6.55 0.34 2.22e-10 Subjective well-being (multi-trait analysis);Menarche (age at onset); CRC cis rs870825 0.655 rs7675046 chr4:185652201 G/A cg07424746 chr4:185654737 MLF1IP 0.51 5.69 0.3 2.8e-8 Blood protein levels; CRC cis rs10504229 0.636 rs77290284 chr8:58055269 G/T cg22535103 chr8:58192502 C8orf71 -0.75 -8.32 -0.42 2.37e-15 Developmental language disorder (linguistic errors); CRC cis rs1957429 0.634 rs7143541 chr14:65419777 G/T cg23373153 chr14:65346875 NA -0.82 -7.02 -0.36 1.31e-11 Pediatric areal bone mineral density (radius); CRC trans rs2303319 0.504 rs62189053 chr2:162624324 G/A cg13490827 chr1:46269305 MAST2 -0.68 -5.99 -0.31 5.44e-9 Cognitive function; CRC cis rs9914988 0.832 rs9903248 chr17:27127439 G/T cg20469991 chr17:27169893 C17orf63 -0.6 -7.27 -0.37 2.59e-12 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs2274273 0.837 rs6573017 chr14:55802243 G/A cg23234261 chr14:55582407 NA -0.29 -5.78 -0.3 1.75e-8 Protein biomarker; CRC cis rs6952808 0.929 rs1801368 chr7:1976457 C/T cg21782813 chr7:2030301 MAD1L1 0.48 7.8 0.4 8.18e-14 Bipolar disorder and schizophrenia; CRC cis rs10256972 0.616 rs4585652 chr7:1145396 A/G cg27094323 chr7:1216898 NA -0.36 -5.7 -0.3 2.65e-8 Longevity;Endometriosis; CRC trans rs2303319 0.504 rs60495163 chr2:162408807 C/T cg09481857 chr22:21368659 P2RX6;MGC16703 -0.64 -6.11 -0.32 2.86e-9 Cognitive function; CRC cis rs10486722 0.565 rs11773175 chr7:41795033 T/G cg22138096 chr7:41772439 LOC285954 0.44 5.67 0.3 3.12e-8 Pit-and-Fissure caries; CRC cis rs12024301 0.557 rs6686912 chr1:183603126 T/C cg11505048 chr1:183622726 RGL1;APOBEC4 0.75 6.81 0.35 4.6e-11 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs3106136 0.903 rs67552174 chr4:95203097 G/A cg11021082 chr4:95130006 SMARCAD1 -0.47 -7.21 -0.37 3.83e-12 Capecitabine sensitivity; CRC cis rs7113874 0.569 rs9300091 chr11:8588823 G/A cg20771178 chr11:8615675 STK33 -0.34 -5.64 -0.3 3.63e-8 Body mass index in physically active individuals;Body mass index (joint analysis main effects and physical activity interaction); CRC trans rs2727020 0.554 rs7111711 chr11:49557880 G/A cg03929089 chr4:120376271 NA -0.76 -10.19 -0.49 2.21e-21 Coronary artery disease; CRC cis rs7927592 0.913 rs11228262 chr11:68274907 G/T cg16797656 chr11:68205561 LRP5 0.37 5.84 0.31 1.27e-8 Total body bone mineral density; CRC cis rs250677 0.652 rs250680 chr5:148436024 T/C cg18129178 chr5:148520854 ABLIM3 -0.36 -5.67 -0.3 3.2e-8 Breast cancer; CRC trans rs1728785 1.000 rs1170434 chr16:68606590 A/G cg04657470 chr2:198365150 HSPE1;HSPD1 0.75 8.94 0.44 2.86e-17 Ulcerative colitis; CRC cis rs6964587 0.934 rs73226382 chr7:91692760 T/C cg17063962 chr7:91808500 NA 0.81 14.11 0.61 1.14e-35 Breast cancer; CRC cis rs780096 0.587 rs4665969 chr2:27574953 C/T cg21248554 chr2:27665150 KRTCAP3 0.27 5.99 0.31 5.61e-9 Total body bone mineral density; CRC cis rs11122272 0.735 rs2024878 chr1:231528415 A/C cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX 0.57 8.45 0.42 9.48e-16 Hemoglobin concentration; CRC cis rs2811415 0.597 rs13079887 chr3:127745248 G/A cg13719885 chr3:127795394 NA -0.39 -5.96 -0.31 6.44e-9 Lung function (FEV1/FVC); CRC cis rs4604732 0.536 rs61184655 chr1:247651342 T/C cg02104434 chr1:247694406 LOC148824;OR2C3 0.57 8.68 0.43 1.84e-16 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CRC cis rs7215564 0.908 rs4243240 chr17:78660342 T/C cg09596252 chr17:78655493 RPTOR 0.54 5.73 0.3 2.25e-8 Myopia (pathological); CRC cis rs9399137 0.507 rs12663447 chr6:135317026 A/C cg24558204 chr6:135376177 HBS1L 0.62 9.46 0.46 5.88e-19 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; CRC cis rs9309473 0.687 rs6706235 chr2:73613558 C/G cg20560298 chr2:73613845 ALMS1 -0.56 -7.58 -0.39 3.63e-13 Metabolite levels; CRC cis rs4290604 0.748 rs6431514 chr2:238051064 T/C cg23555395 chr2:238036564 NA -0.67 -6.77 -0.35 5.83e-11 Asthma; CRC cis rs9916302 0.904 rs585961 chr17:37444036 G/A cg15445000 chr17:37608096 MED1 -0.43 -9.68 -0.47 1.17e-19 Glomerular filtration rate (creatinine); CRC cis rs7647973 0.626 rs4855882 chr3:49715354 G/T cg03060546 chr3:49711283 APEH 0.63 7.1 0.36 7.79e-12 Menarche (age at onset); CRC cis rs6479527 0.901 rs3763639 chr9:96874348 G/T cg14459158 chr9:96720562 NA 0.41 7.12 0.37 6.64e-12 Esophageal adenocarcinoma; CRC cis rs35110281 0.776 rs229357 chr21:44982717 T/C cg04455712 chr21:45112962 RRP1B 0.43 8.37 0.42 1.69e-15 Mean corpuscular volume; CRC trans rs11098499 0.909 rs1546504 chr4:120241179 C/T cg25214090 chr10:38739885 LOC399744 0.63 9.79 0.47 5.04e-20 Corneal astigmatism; CRC cis rs2652834 1.000 rs2729783 chr15:63403316 C/T cg05507819 chr15:63340323 TPM1 0.45 5.75 0.3 1.99e-8 HDL cholesterol; CRC cis rs10504229 1.000 rs114312649 chr8:58182539 C/G cg02290350 chr8:58132656 NA -0.42 -5.96 -0.31 6.62e-9 Developmental language disorder (linguistic errors); CRC cis rs28386778 0.897 rs2727330 chr17:61925498 A/G cg11494091 chr17:61959527 GH2 -0.59 -10.36 -0.5 5.81e-22 Prudent dietary pattern; CRC cis rs1448094 0.511 rs17279464 chr12:86164473 C/T cg18827107 chr12:86230957 RASSF9 -0.37 -5.72 -0.3 2.4e-8 Major depressive disorder; CRC cis rs17270561 0.636 rs6456694 chr6:25712894 C/T cg17691542 chr6:26056736 HIST1H1C 0.63 8.04 0.41 1.64e-14 Iron status biomarkers; CRC cis rs6502050 0.835 rs12600852 chr17:80104593 G/A cg11859384 chr17:80120422 CCDC57 -0.37 -5.85 -0.31 1.16e-8 Life satisfaction; CRC cis rs736408 0.511 rs12637632 chr3:52708073 A/T cg10802521 chr3:52805072 NEK4 -0.58 -8.84 -0.44 5.97e-17 Bipolar disorder; CRC cis rs4757319 0.532 rs7350480 chr11:15431408 A/G cg03245590 chr11:15329459 NA -0.43 -7.48 -0.38 6.72e-13 Breast cancer; CRC cis rs8060686 0.858 rs7196789 chr16:67927124 C/T cg00318322 chr16:67708822 GFOD2 -0.31 -5.94 -0.31 7.11e-9 HDL cholesterol;Metabolic syndrome; CRC cis rs3820068 0.581 rs16851855 chr1:15930869 G/A cg27534772 chr1:16042836 PLEKHM2 0.54 10.46 0.5 2.7e-22 Systolic blood pressure; CRC cis rs1577917 1.000 rs34622557 chr6:86630852 C/A cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.51 -6.74 -0.35 7.09e-11 Response to antipsychotic treatment; CRC trans rs875971 0.545 rs2173571 chr7:65770379 G/A cg02869306 chr7:64672164 INTS4L1 -0.44 -6.45 -0.34 3.9e-10 Aortic root size; CRC trans rs1814175 0.817 rs10839358 chr11:49770972 G/A cg15704280 chr7:45808275 SEPT13 -1.01 -20.58 -0.75 4.39e-61 Height; CRC cis rs6788895 1.000 rs7617507 chr3:150499595 C/T cg09723797 chr3:150481914 SIAH2 -0.83 -6.81 -0.35 4.56e-11 Breast cancer; CRC cis rs9443645 0.901 rs9448584 chr6:79572799 G/T cg09184832 chr6:79620586 NA -0.51 -9.55 -0.47 3.13e-19 Intelligence (multi-trait analysis); CRC cis rs1577917 1.000 rs13196930 chr6:86652245 C/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.56 -6.96 -0.36 1.8e-11 Response to antipsychotic treatment; CRC cis rs10865541 0.902 rs10173635 chr2:3421213 G/A cg22182287 chr2:3452347 TTC15 0.38 5.98 0.31 5.71e-9 Obesity-related traits; CRC cis rs7527798 0.592 rs6684643 chr1:207846242 A/T cg09232269 chr1:207846808 CR1L -0.52 -8.31 -0.42 2.49e-15 Erythrocyte sedimentation rate; CRC cis rs7666738 0.791 rs34437628 chr4:99029232 C/G cg05340658 chr4:99064831 C4orf37 0.61 9.42 0.46 8.23e-19 Colonoscopy-negative controls vs population controls; CRC cis rs4664293 0.585 rs13019325 chr2:160628990 A/G cg08347373 chr2:160653686 CD302 0.36 5.95 0.31 6.92e-9 Monocyte percentage of white cells; CRC cis rs2991971 0.729 rs10890328 chr1:45905383 G/T cg24296786 chr1:45957014 TESK2 -0.47 -6.85 -0.35 3.57e-11 High light scatter reticulocyte count; CRC cis rs6502050 0.731 rs34796376 chr17:80116635 G/T cg13198984 chr17:80129470 CCDC57 0.45 8.07 0.41 1.3e-14 Life satisfaction; CRC cis rs7849270 1.000 rs2297112 chr9:131900180 G/A cg13538475 chr9:131942899 NA -0.32 -6.37 -0.33 6.2e-10 Blood metabolite ratios; CRC cis rs919433 0.963 rs1429417 chr2:198158171 T/G cg20885578 chr2:198174922 NA -0.36 -6.44 -0.33 4.19e-10 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC cis rs875971 0.545 rs1796226 chr7:66087710 C/T cg05627663 chr7:65219948 SNORA22;CCT6P1 0.61 7.97 0.4 2.67e-14 Aortic root size; CRC cis rs9733 0.596 rs6690725 chr1:150632322 T/C cg10589385 chr1:150898437 SETDB1 0.28 5.98 0.31 5.86e-9 Tonsillectomy; CRC cis rs4919687 0.679 rs12762176 chr10:104499232 A/T cg04362960 chr10:104952993 NT5C2 0.5 6.14 0.32 2.38e-9 Colorectal cancer; CRC cis rs6496667 0.580 rs8030736 chr15:90885866 T/C cg04176472 chr15:90893244 GABARAPL3 0.56 6.69 0.35 9.64e-11 Rheumatoid arthritis; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg15563057 chr5:139493612 PURA 0.54 7.08 0.36 8.51e-12 Thyroid stimulating hormone; CRC cis rs10504229 1.000 rs73607875 chr8:58173522 T/C cg22535103 chr8:58192502 C8orf71 -0.82 -12.27 -0.56 9.63e-29 Developmental language disorder (linguistic errors); CRC cis rs1552244 0.554 rs3846167 chr3:9996426 T/C cg16606324 chr3:10149918 C3orf24 0.45 6.82 0.35 4.25e-11 Alzheimer's disease; CRC cis rs427394 0.772 rs274689 chr5:6736215 G/C cg10857441 chr5:6722123 POLS -0.36 -5.62 -0.3 4.16e-8 Menopause (age at onset); CRC cis rs8078723 0.690 rs56326707 chr17:38130139 C/T cg17344932 chr17:38183730 MED24;SNORD124 -0.54 -8.77 -0.44 9.68e-17 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); CRC cis rs758324 0.812 rs11750031 chr5:131171251 G/A cg25547332 chr5:131281432 NA 0.35 5.68 0.3 3.03e-8 Alzheimer's disease in APOE e4- carriers; CRC cis rs6570726 0.846 rs426874 chr6:145880630 A/C cg23711669 chr6:146136114 FBXO30 0.66 11.05 0.52 2.33e-24 Lobe attachment (rater-scored or self-reported); CRC cis rs972578 0.765 rs5759081 chr22:43396445 A/G cg01576275 chr22:43409880 NA -0.4 -6.15 -0.32 2.21e-9 Mean platelet volume; CRC cis rs7259376 0.967 rs7252056 chr19:22494052 T/A cg02657401 chr19:22469223 NA -0.35 -7.85 -0.4 6.02e-14 Menopause (age at onset); CRC trans rs10242455 0.702 rs3823813 chr7:99049389 G/A cg09045935 chr12:6379348 NA 1.07 7.87 0.4 5.09e-14 Blood metabolite levels; CRC cis rs6088580 0.634 rs4911153 chr20:32961547 C/T cg24642439 chr20:33292090 TP53INP2 -0.41 -6.81 -0.35 4.52e-11 Glomerular filtration rate (creatinine); CRC cis rs6831352 0.918 rs17218288 chr4:100058030 A/T cg13256891 chr4:100009986 ADH5 -0.66 -8.95 -0.44 2.62e-17 Alcohol dependence; CRC cis rs10504229 0.775 rs17216236 chr8:58159352 G/A cg05313129 chr8:58192883 C8orf71 -0.48 -6.23 -0.32 1.46e-9 Developmental language disorder (linguistic errors); CRC trans rs3808502 0.549 rs1382563 chr8:11426790 C/G cg06636001 chr8:8085503 FLJ10661 0.52 8.12 0.41 9.35e-15 Neuroticism; CRC cis rs34172651 0.917 rs11074654 chr16:24813743 A/G cg00339695 chr16:24857497 SLC5A11 0.27 6.4 0.33 5.4e-10 Intelligence (multi-trait analysis); CRC cis rs12545109 0.800 rs970838 chr8:57414806 A/G cg09654669 chr8:57350985 NA -0.45 -7.22 -0.37 3.56e-12 Obesity-related traits; CRC cis rs4713118 0.666 rs4140646 chr6:27738801 G/A cg20933634 chr6:27740509 NA 0.63 7.31 0.37 2.09e-12 Parkinson's disease; CRC cis rs375066 0.935 rs11673020 chr19:44374631 A/G cg12072164 chr19:44306565 LYPD5 0.37 5.61 0.3 4.31e-8 Breast cancer; CRC cis rs10504229 0.728 rs17804750 chr8:58155751 T/C cg02725872 chr8:58115012 NA -0.57 -9.07 -0.45 1.09e-17 Developmental language disorder (linguistic errors); CRC cis rs2479724 0.901 rs2185798 chr6:41773576 G/C cg17623882 chr6:41773611 USP49 0.58 9.8 0.48 4.72e-20 Menarche (age at onset); CRC cis rs9322193 0.923 rs10872644 chr6:150062955 T/C cg00933542 chr6:150070202 PCMT1 0.31 6.36 0.33 6.65e-10 Lung cancer; CRC trans rs67340775 0.541 rs200968 chr6:27859568 T/C cg06606381 chr12:133084897 FBRSL1 -0.61 -6.02 -0.31 4.73e-9 Lung cancer in ever smokers; CRC cis rs10504229 0.595 rs76447299 chr8:58117395 A/G cg05313129 chr8:58192883 C8orf71 -0.43 -6.11 -0.32 2.74e-9 Developmental language disorder (linguistic errors); CRC cis rs1005277 0.602 rs1780141 chr10:38504299 T/C cg25427524 chr10:38739819 LOC399744 -0.79 -14.49 -0.62 3.9e-37 Extrinsic epigenetic age acceleration; CRC trans rs8073060 0.586 rs8077826 chr17:34001139 G/A cg19694781 chr19:47549865 TMEM160 -1.06 -15.04 -0.64 2.94e-39 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; CRC cis rs2019137 0.936 rs12612729 chr2:113957048 G/A cg21482265 chr2:113992762 PAX8;LOC440839;LOC654433 -0.46 -6.58 -0.34 1.87e-10 Lymphocyte counts; CRC cis rs78456975 1.000 rs72776252 chr2:1525599 G/A cg01028140 chr2:1542097 TPO -0.58 -5.71 -0.3 2.54e-8 Placebo response in major depressive disorder (% change in symptom score); CRC cis rs6545883 0.718 rs3771260 chr2:61762384 G/T cg15711740 chr2:61764176 XPO1 -0.52 -7.13 -0.37 6.43e-12 Tuberculosis; CRC trans rs1005277 0.602 rs1740743 chr10:38519222 C/T cg11292332 chr7:45801988 SEPT13 -0.39 -7.05 -0.36 1.05e-11 Extrinsic epigenetic age acceleration; CRC cis rs4332037 0.707 rs62435132 chr7:1891315 C/T cg23378565 chr7:2036160 MAD1L1 -0.4 -6.04 -0.32 4.11e-9 Bipolar disorder; CRC trans rs3791556 1.000 rs3791568 chr2:240115701 G/A cg00066750 chr6:126080132 HEY2 0.59 6.18 0.32 1.84e-9 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs5769765 0.862 rs9616384 chr22:50313082 C/T cg02269571 chr22:50332266 NA -0.61 -7.92 -0.4 3.64e-14 Schizophrenia; CRC cis rs6460942 0.915 rs6945067 chr7:12444731 A/C cg20607287 chr7:12443886 VWDE -0.68 -7.35 -0.38 1.59e-12 Coronary artery disease; CRC cis rs6088590 1.000 rs11698977 chr20:33449691 C/T cg24642439 chr20:33292090 TP53INP2 0.52 8.94 0.44 2.92e-17 Coronary artery disease; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg08316941 chr5:133984937 SEC24A 0.48 6.75 0.35 6.6e-11 Response to antipsychotic treatment; CRC cis rs9660180 0.967 rs6603802 chr1:1812521 C/T cg17747265 chr1:1875780 NA -0.76 -13.13 -0.59 5.71e-32 Body mass index; CRC cis rs394563 0.517 rs377454 chr6:149791093 T/C cg11245181 chr6:149772854 ZC3H12D -0.55 -8.62 -0.43 2.89e-16 Dupuytren's disease; CRC trans rs916888 0.773 rs199533 chr17:44828931 G/A cg07870213 chr5:140052090 DND1 1.04 11.36 0.53 1.94e-25 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs13191362 1.000 rs67747005 chr6:163150845 G/A cg06582575 chr6:163149167 PACRG;PARK2 0.8 11.03 0.52 2.73e-24 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs4563143 0.675 rs73025085 chr19:29247018 C/A cg03161606 chr19:29218774 NA 0.52 6.52 0.34 2.68e-10 Methadone dose in opioid dependence; CRC cis rs919433 0.963 rs12469546 chr2:198178826 T/C cg03934865 chr2:198174659 NA -0.44 -6.95 -0.36 1.99e-11 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC cis rs394563 0.589 rs1900300 chr6:149641627 T/C cg07828024 chr6:149772892 ZC3H12D 0.47 8.57 0.43 4.05e-16 Dupuytren's disease; CRC trans rs6601327 0.641 rs7014663 chr8:9587275 G/T cg06636001 chr8:8085503 FLJ10661 -0.5 -7.31 -0.37 2.08e-12 Multiple myeloma (hyperdiploidy); CRC cis rs4975709 0.589 rs4975744 chr5:1860049 A/G cg11168104 chr5:1857477 NA -0.4 -6.87 -0.35 3.16e-11 Cardiovascular disease risk factors; CRC cis rs9457247 0.935 rs9348211 chr6:167375173 G/C cg23791538 chr6:167370224 RNASET2 0.38 5.87 0.31 1.04e-8 Crohn's disease; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg13672843 chr3:10183721 VHL 0.46 6.59 0.34 1.72e-10 Anxiety disorder; CRC cis rs853679 0.546 rs200490 chr6:27796935 G/T cg26587870 chr6:27730563 NA -0.66 -6.83 -0.35 4.21e-11 Depression; CRC cis rs4332037 0.707 rs73046323 chr7:1882795 G/A cg23378565 chr7:2036160 MAD1L1 -0.41 -6.2 -0.32 1.67e-9 Bipolar disorder; CRC cis rs1865760 0.892 rs9379806 chr6:25940958 G/A cg16482183 chr6:26056742 HIST1H1C 0.53 7.41 0.38 1.05e-12 Height; CRC cis rs72781680 1.000 rs12614452 chr2:24194608 C/T cg08917208 chr2:24149416 ATAD2B 0.91 9.28 0.46 2.29e-18 Lymphocyte counts; CRC cis rs11677416 1.000 rs6542091 chr2:113525311 G/A cg27083787 chr2:113543245 IL1A 0.45 6.47 0.34 3.5e-10 Response to antipsychotic treatment in schizophrenia (working memory); CRC trans rs11098499 0.865 rs10213221 chr4:120255926 G/A cg25214090 chr10:38739885 LOC399744 0.54 8.46 0.42 8.78e-16 Corneal astigmatism; CRC cis rs1915919 0.794 rs12488378 chr3:20022495 C/G cg05072819 chr3:20081367 KAT2B 0.5 7.33 0.37 1.77e-12 Post-traumatic stress disorder; CRC cis rs2386661 0.547 rs11259742 chr10:5647078 C/T cg26603656 chr10:5671107 NA 0.44 7.51 0.38 5.48e-13 Breast cancer; CRC cis rs4731207 0.698 rs10248775 chr7:124444207 T/G cg23710748 chr7:124431027 NA 0.37 5.96 0.31 6.53e-9 Cutaneous malignant melanoma; CRC cis rs7618915 0.570 rs11714088 chr3:52758942 A/C cg07507251 chr3:52567010 NT5DC2 0.4 5.75 0.3 2.04e-8 Bipolar disorder; CRC cis rs2985684 0.779 rs12160 chr14:50091932 T/A cg04989706 chr14:50066350 PPIL5 -0.54 -7.47 -0.38 7.5e-13 Carotid intima media thickness; CRC cis rs600626 0.588 rs10793124 chr11:75452267 C/G cg24262691 chr11:75473276 NA 0.53 7.49 0.38 6.21e-13 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CRC cis rs9329289 0.851 rs61835719 chr10:2543390 A/G cg05625103 chr10:2543513 NA 0.38 5.95 0.31 6.96e-9 Age-related hearing impairment; CRC cis rs79387448 0.745 rs74560841 chr2:103149210 G/A cg21010569 chr2:103233596 NA 0.55 5.81 0.3 1.51e-8 Gut microbiota (bacterial taxa); CRC cis rs6461049 0.765 rs4719432 chr7:2140330 A/G cg08027265 chr7:2291960 NA -0.37 -6.38 -0.33 5.91e-10 Schizophrenia; CRC cis rs853679 0.517 rs9368556 chr6:28131153 T/C cg23161317 chr6:28129485 ZNF389 0.53 6.43 0.33 4.52e-10 Depression; CRC trans rs1814175 0.935 rs7482690 chr11:49648814 C/T cg03929089 chr4:120376271 NA -0.93 -16.75 -0.68 5.61e-46 Height; CRC cis rs2982552 1.000 rs2982552 chr6:152059563 G/A cg22157087 chr6:152012887 ESR1 0.37 5.76 0.3 1.96e-8 Bone properties (heel); CRC cis rs4927850 0.723 rs7630825 chr3:195753740 T/C cg12923728 chr3:195709715 SDHAP1 -0.74 -12.05 -0.55 5.84e-28 Pancreatic cancer; CRC cis rs9942416 0.660 rs1817869 chr5:74989037 T/C cg19683494 chr5:74908142 NA 0.5 6.28 0.33 1.06e-9 Age-related disease endophenotypes; CRC cis rs1008375 0.966 rs6833808 chr4:17652526 T/A cg02297831 chr4:17616191 MED28 0.5 6.71 0.35 8.74e-11 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs4243830 0.737 rs11122088 chr1:6603677 T/G cg22792644 chr1:6614718 TAS1R1;NOL9 -0.7 -7.88 -0.4 4.88e-14 Body mass index; CRC cis rs4927850 0.918 rs4361313 chr3:195752260 A/G cg12923728 chr3:195709715 SDHAP1 -0.71 -11.07 -0.52 2.01e-24 Pancreatic cancer; CRC trans rs61931739 0.500 rs35030191 chr12:34548865 C/T cg26384229 chr12:38710491 ALG10B 0.67 8.78 0.44 9.34e-17 Morning vs. evening chronotype; CRC cis rs2075371 0.829 rs727202 chr7:133947942 A/G cg02659138 chr7:134003124 SLC35B4 0.39 6.62 0.34 1.46e-10 Mean platelet volume; CRC cis rs9660992 0.573 rs1318187 chr1:205206172 T/A cg00857998 chr1:205179979 DSTYK 0.42 5.61 0.3 4.25e-8 Mean corpuscular volume;Mean platelet volume; CRC cis rs9326248 0.539 rs7120565 chr11:117042949 T/C cg26566898 chr11:117069891 TAGLN 0.32 6.89 0.35 2.93e-11 Blood protein levels; CRC cis rs6088580 0.542 rs6059882 chr20:33090167 T/C cg24642439 chr20:33292090 TP53INP2 0.4 6.57 0.34 1.97e-10 Glomerular filtration rate (creatinine); CRC cis rs6952808 1.000 rs4721122 chr7:1893311 C/G cg22963979 chr7:1858916 MAD1L1 -0.6 -9.44 -0.46 6.88e-19 Bipolar disorder and schizophrenia; CRC cis rs801193 1.000 rs2659912 chr7:66157999 G/C cg18876405 chr7:65276391 NA 0.61 10.76 0.51 2.53e-23 Aortic root size; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg13412395 chr9:102583693 NR4A3 0.43 6.18 0.32 1.87e-9 Response to antipsychotic treatment; CRC cis rs2976388 0.609 rs1469811 chr8:143787999 C/T cg12516270 chr8:143859308 LYNX1 0.44 7.88 0.4 4.71e-14 Urinary tract infection frequency; CRC cis rs7147624 0.573 rs10148699 chr14:66199662 G/A cg03016385 chr14:66212404 NA -1.03 -10.36 -0.5 5.94e-22 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs7223966 1.000 rs2854219 chr17:61942682 C/T cg23090583 chr17:61904693 PSMC5;FTSJ3 0.59 7.22 0.37 3.66e-12 Hip circumference adjusted for BMI;Body mass index; CRC cis rs7918232 1.000 rs6482595 chr10:27380261 A/G cg14240646 chr10:27532245 ACBD5 0.7 8.5 0.42 6.68e-16 Breast cancer; CRC cis rs7264396 0.690 rs2425171 chr20:34443173 G/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.6 -10.15 -0.49 3.1e-21 Total cholesterol levels; CRC trans rs2235573 0.517 rs4821727 chr22:38393423 C/A cg19894588 chr14:64061835 NA 0.49 7.2 0.37 4.11e-12 Glioblastoma;Glioma; CRC cis rs79839061 0.610 rs11732965 chr4:869359 C/A cg07828340 chr4:882639 GAK 1.12 10.93 0.52 6.49e-24 Intelligence (multi-trait analysis); CRC cis rs7927592 0.913 rs7104345 chr11:68316772 G/A cg16797656 chr11:68205561 LRP5 0.36 5.71 0.3 2.47e-8 Total body bone mineral density; CRC cis rs10504229 1.000 rs60651159 chr8:58174074 T/C cg02725872 chr8:58115012 NA -0.38 -6.43 -0.33 4.44e-10 Developmental language disorder (linguistic errors); CRC cis rs4722166 0.630 rs1581497 chr7:22779503 C/A cg26061582 chr7:22766209 IL6 0.55 8.35 0.42 1.92e-15 Lung cancer; CRC cis rs1395 0.778 rs56364136 chr2:27451429 T/C cg23587288 chr2:27483067 SLC30A3 -0.32 -5.67 -0.3 3.09e-8 Blood metabolite levels; CRC cis rs9916302 0.706 rs8073907 chr17:37424149 C/T cg15445000 chr17:37608096 MED1 0.36 6.4 0.33 5.4e-10 Glomerular filtration rate (creatinine); CRC cis rs13191362 0.872 rs13196631 chr6:163001588 A/G cg06582575 chr6:163149167 PACRG;PARK2 0.79 10.88 0.51 9.36e-24 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC trans rs57221529 0.766 rs12522140 chr5:587261 C/A cg11887960 chr12:57824829 NA 0.63 6.89 0.36 2.93e-11 Lung disease severity in cystic fibrosis; CRC cis rs76878669 0.516 rs7104570 chr11:66159098 A/G cg24851651 chr11:66362959 CCS -0.34 -5.7 -0.3 2.61e-8 Educational attainment (years of education); CRC cis rs727505 1.000 rs17246404 chr7:124462661 C/T cg23710748 chr7:124431027 NA -0.85 -15.17 -0.64 8.49e-40 Lewy body disease; CRC cis rs66887589 0.720 rs2036858 chr4:120249237 A/C cg09307838 chr4:120376055 NA 0.56 8.68 0.43 1.88e-16 Diastolic blood pressure; CRC cis rs1799949 0.929 rs12937015 chr17:41307473 A/C cg23758822 chr17:41437982 NA 0.79 13.51 0.6 2.13e-33 Menopause (age at onset); CRC cis rs2415984 0.622 rs2817568 chr14:46940986 C/G cg14871534 chr14:47121158 RPL10L 0.42 5.93 0.31 7.82e-9 Number of children ever born; CRC trans rs8002861 0.765 rs12868462 chr13:44453480 C/T cg17145862 chr1:211918768 LPGAT1 -0.73 -13.43 -0.6 4.24e-33 Leprosy; CRC cis rs449303 1 rs449303 chr14:60605788 A/G cg00846580 chr14:60632234 DHRS7 0.55 6.08 0.32 3.26e-9 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs1799949 0.965 rs799908 chr17:41278916 A/G cg23758822 chr17:41437982 NA 0.85 15.74 0.66 5.32e-42 Menopause (age at onset); CRC cis rs4919694 1.000 rs4917988 chr10:104752830 T/G cg04362960 chr10:104952993 NT5C2 1.16 10.74 0.51 2.86e-23 Arsenic metabolism; CRC cis rs904251 0.772 rs10692 chr6:37450914 T/C cg01843034 chr6:37503916 NA -0.35 -5.84 -0.31 1.26e-8 Cognitive performance; CRC cis rs2992756 0.663 rs1316327 chr1:18802387 G/A cg14356550 chr1:18808102 KLHDC7A -0.4 -5.69 -0.3 2.74e-8 Breast cancer; CRC cis rs3806843 0.900 rs2563286 chr5:140125199 T/A cg16607685 chr5:140181889 PCDHA2;PCDHA1;PCDHA3 0.26 6.11 0.32 2.89e-9 Depressive symptoms (multi-trait analysis); CRC cis rs875971 0.638 rs6960778 chr7:66071597 C/T cg11764359 chr7:65958608 NA -0.55 -8.55 -0.43 4.78e-16 Aortic root size; CRC cis rs11252926 0.966 rs11252923 chr10:566195 G/A cg18196295 chr10:418757 DIP2C -0.54 -7.45 -0.38 8.53e-13 Psychosis in Alzheimer's disease; CRC cis rs6964587 0.626 rs4729011 chr7:91515419 G/A cg17063962 chr7:91808500 NA -0.58 -9.22 -0.45 3.52e-18 Breast cancer; CRC cis rs6952808 1.000 rs4721121 chr7:1892565 A/G cg21782813 chr7:2030301 MAD1L1 0.43 7.39 0.38 1.25e-12 Bipolar disorder and schizophrenia; CRC trans rs7395662 0.963 rs12418721 chr11:48618451 C/T cg21153622 chr11:89784906 NA -0.48 -7.68 -0.39 1.78e-13 HDL cholesterol; CRC cis rs881375 0.933 rs7859805 chr9:123664123 A/G cg09419670 chr9:123605666 PSMD5;LOC253039 0.6 8.81 0.44 7.32e-17 Rheumatoid arthritis; CRC cis rs939658 1.000 rs34286854 chr15:79454374 C/T cg17916960 chr15:79447300 NA -0.44 -7.37 -0.38 1.41e-12 Refractive error; CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg02902800 chr4:6784175 KIAA0232 0.37 6.0 0.31 5.08e-9 Obesity-related traits; CRC cis rs10504229 0.683 rs11775568 chr8:58133762 G/A cg08219700 chr8:58056026 NA 0.57 6.86 0.35 3.5e-11 Developmental language disorder (linguistic errors); CRC cis rs66887589 0.616 rs11098498 chr4:120187119 T/C cg09307838 chr4:120376055 NA 0.54 8.38 0.42 1.57e-15 Diastolic blood pressure; CRC cis rs763014 0.932 rs2269559 chr16:682297 T/C cg02475695 chr16:616220 NHLRC4 0.45 7.2 0.37 4.08e-12 Height; CRC cis rs10504229 0.724 rs73603871 chr8:58107612 A/G cg22535103 chr8:58192502 C8orf71 -0.69 -8.8 -0.44 7.79e-17 Developmental language disorder (linguistic errors); CRC cis rs769267 0.931 rs15622 chr19:19468734 G/A cg03709012 chr19:19516395 GATAD2A -0.71 -10.83 -0.51 1.4e-23 Tonsillectomy; CRC cis rs10504229 1.000 rs67243305 chr8:58174958 G/A cg01721255 chr8:58191610 C8orf71 0.49 6.14 0.32 2.32e-9 Developmental language disorder (linguistic errors); CRC cis rs11790388 0.505 rs670410 chr9:129700537 A/G cg08433538 chr9:129676714 RALGPS1 0.35 5.62 0.3 4.1e-8 Schizophrenia; CRC cis rs7249142 0.549 rs539 chr19:19287802 A/G cg08207377 chr19:19281140 LOC729991-MEF2B;MEF2B -0.37 -5.98 -0.31 5.78e-9 IgG glycosylation; CRC cis rs7615952 0.576 rs2276726 chr3:125826287 C/G cg06494592 chr3:125709126 NA -0.47 -5.86 -0.31 1.13e-8 Blood pressure (smoking interaction); CRC cis rs9916302 0.904 rs612194 chr17:37442707 T/A cg00129232 chr17:37814104 STARD3 0.55 8.16 0.41 6.95e-15 Glomerular filtration rate (creatinine); CRC cis rs28386778 0.700 rs11079515 chr17:62005645 C/G cg25654072 chr17:61904446 PSMC5;FTSJ3 -0.49 -7.0 -0.36 1.44e-11 Prudent dietary pattern; CRC cis rs7666738 0.830 rs7672720 chr4:98938760 A/T cg17366294 chr4:99064904 C4orf37 0.43 7.35 0.38 1.63e-12 Colonoscopy-negative controls vs population controls; CRC cis rs7208859 0.562 rs11650923 chr17:29008167 G/A cg13385521 chr17:29058706 SUZ12P 0.71 7.7 0.39 1.64e-13 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs17270561 0.609 rs4711103 chr6:25742224 C/T cg17691542 chr6:26056736 HIST1H1C 0.72 9.24 0.45 3.07e-18 Iron status biomarkers; CRC cis rs2204008 0.641 rs66876045 chr12:38205713 G/A cg26384229 chr12:38710491 ALG10B 0.68 9.04 0.45 1.4e-17 Bladder cancer; CRC cis rs11249608 0.636 rs13359572 chr5:178449276 T/C cg01312482 chr5:178451176 ZNF879 -0.36 -6.07 -0.32 3.55e-9 Pubertal anthropometrics; CRC cis rs1163251 0.902 rs640195 chr1:120217650 T/A cg19096424 chr1:120255104 PHGDH 0.46 6.65 0.34 1.2e-10 Blood metabolite levels; CRC cis rs2019137 0.936 rs731834 chr2:113957198 A/C cg07772999 chr2:113993052 PAX8;LOC440839;LOC654433 -0.45 -6.34 -0.33 7.78e-10 Lymphocyte counts; CRC cis rs514406 0.621 rs2003250 chr1:53196666 T/C cg08859206 chr1:53392774 SCP2 0.42 6.51 0.34 2.76e-10 Monocyte count; CRC cis rs9649213 0.593 rs7797943 chr7:97946902 T/C cg00277769 chr7:97922759 BAIAP2L1 -0.62 -10.88 -0.51 9e-24 Prostate cancer (SNP x SNP interaction); CRC cis rs7103648 0.966 rs874896 chr11:47418953 C/G cg20307385 chr11:47447363 PSMC3 1.0 18.18 0.71 1.25e-51 Diastolic blood pressure;Systolic blood pressure; CRC cis rs4713118 0.955 rs34752872 chr6:27683244 A/T cg02683197 chr6:28174875 NA 0.56 7.16 0.37 5.29e-12 Parkinson's disease; CRC cis rs736408 0.522 rs11716747 chr3:52748857 C/T cg10802521 chr3:52805072 NEK4 -0.58 -9.05 -0.45 1.31e-17 Bipolar disorder; CRC cis rs6964587 0.610 rs2888850 chr7:91430027 T/C cg17063962 chr7:91808500 NA 0.57 8.77 0.44 9.8e-17 Breast cancer; CRC cis rs10782582 0.586 rs1796813 chr1:76400403 G/A cg10523679 chr1:76189770 ACADM -0.43 -6.29 -0.33 9.93e-10 Daytime sleep phenotypes; CRC cis rs2625529 0.652 rs2929525 chr15:72287856 G/A cg16672083 chr15:72433130 SENP8 0.43 6.32 0.33 8.27e-10 Red blood cell count; CRC cis rs9398803 0.865 rs1907067 chr6:126837663 A/C cg19875578 chr6:126661172 C6orf173 0.43 5.78 0.3 1.78e-8 Male-pattern baldness; CRC cis rs7613875 0.600 rs2856238 chr3:50158191 C/T cg24110177 chr3:50126178 RBM5 -0.58 -9.15 -0.45 6.26e-18 Body mass index; CRC cis rs16975963 0.644 rs75499934 chr19:38113043 C/A cg15135657 chr19:38346511 NA -0.46 -6.28 -0.33 1.04e-9 Longevity; CRC cis rs10463316 0.894 rs4099169 chr5:150766526 C/T cg03212797 chr5:150827313 SLC36A1 -0.49 -7.66 -0.39 2.06e-13 Metabolite levels (Pyroglutamine); CRC cis rs2645694 0.651 rs2703144 chr4:77830505 C/G cg03477792 chr4:77819574 ANKRD56 0.46 6.62 0.34 1.48e-10 Emphysema distribution in smoking; CRC cis rs4664293 0.667 rs6432562 chr2:160648006 A/T cg08347373 chr2:160653686 CD302 -0.55 -9.43 -0.46 7.77e-19 Monocyte percentage of white cells; CRC cis rs10751667 0.666 rs6597957 chr11:982294 T/A cg23136738 chr11:925521 AP2A2 -0.4 -6.63 -0.34 1.4e-10 Alzheimer's disease (late onset); CRC cis rs919433 0.963 rs13033821 chr2:198173536 T/G cg20885578 chr2:198174922 NA -0.44 -6.96 -0.36 1.83e-11 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC cis rs9902453 0.967 rs17825877 chr17:28515188 C/T cg26525008 chr17:28256777 EFCAB5;SSH2 0.6 9.34 0.46 1.47e-18 Coffee consumption (cups per day); CRC cis rs2067615 0.579 rs11113119 chr12:107200056 C/A cg13491945 chr12:107078410 RFX4 0.36 6.11 0.32 2.77e-9 Heart rate; CRC cis rs372883 0.648 rs15092 chr21:30718201 G/A cg08807101 chr21:30365312 RNF160 -0.53 -7.43 -0.38 9.37e-13 Pancreatic cancer; CRC cis rs208520 1.000 rs72884033 chr6:66995747 T/C cg07460842 chr6:66804631 NA 0.92 11.19 0.53 7.51e-25 Exhaled nitric oxide output; CRC trans rs6788895 0.661 rs16862837 chr3:150469858 A/C cg03041920 chr13:100310311 CLYBL 0.61 6.34 0.33 7.78e-10 Breast cancer; CRC cis rs8180040 0.620 rs9845728 chr3:47103376 C/T cg27129171 chr3:47204927 SETD2 0.72 11.33 0.53 2.45e-25 Colorectal cancer; CRC cis rs3858526 0.883 rs10769326 chr11:5934358 C/T cg13902645 chr11:5959945 NA -0.61 -8.57 -0.43 4.2e-16 DNA methylation (variation); CRC cis rs12024301 0.557 rs76439498 chr1:183643395 T/C cg11505048 chr1:183622726 RGL1;APOBEC4 0.78 6.64 0.34 1.27e-10 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs7666738 0.830 rs11723283 chr4:99001617 C/T cg17366294 chr4:99064904 C4orf37 0.44 7.39 0.38 1.19e-12 Colonoscopy-negative controls vs population controls; CRC cis rs8180040 0.545 rs9311403 chr3:47138878 T/C cg27129171 chr3:47204927 SETD2 0.72 11.37 0.53 1.78e-25 Colorectal cancer; CRC cis rs11098499 0.754 rs12510269 chr4:120241646 A/G cg09307838 chr4:120376055 NA 0.62 9.71 0.47 9.4e-20 Corneal astigmatism; CRC cis rs10886503 0.777 rs7101354 chr10:121267016 C/T cg17804342 chr10:121271663 RGS10 0.79 7.99 0.4 2.29e-14 Obstetric antiphospholipid syndrome; CRC cis rs11252926 0.931 rs12355162 chr10:563472 G/A cg18196295 chr10:418757 DIP2C -0.53 -7.22 -0.37 3.58e-12 Psychosis in Alzheimer's disease; CRC cis rs11212617 1.000 rs228594 chr11:108104525 A/G cg14761454 chr11:108092087 ATM;NPAT 0.4 5.84 0.31 1.26e-8 Response to metformin in type 2 diabetes (glycemic); CRC cis rs10489202 0.632 rs413168 chr1:168005789 C/G cg24449463 chr1:168025552 DCAF6 -0.58 -8.74 -0.43 1.2e-16 Schizophrenia; CRC cis rs11148252 0.712 rs61957257 chr13:52769702 G/A cg02158880 chr13:53174818 NA 0.45 6.84 0.35 3.95e-11 Lewy body disease; CRC cis rs921968 0.541 rs7583449 chr2:219403022 A/C cg02176678 chr2:219576539 TTLL4 -0.61 -9.72 -0.47 8.32e-20 Mean corpuscular hemoglobin concentration; CRC cis rs11098499 0.954 rs6834796 chr4:120414693 A/C cg09307838 chr4:120376055 NA 0.71 10.89 0.51 8.78e-24 Corneal astigmatism; CRC cis rs7493 0.901 rs2237586 chr7:95051052 G/T cg07404485 chr7:94953653 PON1 -0.47 -6.05 -0.32 3.87e-9 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs9487051 0.652 rs9372210 chr6:109601703 G/C cg21918786 chr6:109611834 NA -0.42 -7.3 -0.37 2.15e-12 Reticulocyte fraction of red cells; CRC cis rs7769051 0.711 rs7770081 chr6:133089569 G/T cg07930552 chr6:133119739 C6orf192 0.6 7.18 0.37 4.55e-12 Type 2 diabetes nephropathy; CRC cis rs9903692 0.954 rs8080662 chr17:46190819 C/T cg21215337 chr17:46176117 CBX1 -0.41 -7.48 -0.38 6.85e-13 Pulse pressure; CRC cis rs7666738 0.830 rs28485415 chr4:99060340 G/A cg17366294 chr4:99064904 C4orf37 0.44 7.49 0.38 6.54e-13 Colonoscopy-negative controls vs population controls; CRC cis rs9901225 1 rs9901225 chr17:40755811 C/T cg16308533 chr17:40838983 CNTNAP1 0.4 6.49 0.34 3.07e-10 Colorectal or endometrial cancer; CRC cis rs4713118 0.586 rs9468290 chr6:28087674 C/T cg02631126 chr6:28058918 ZSCAN12L1 0.29 5.87 0.31 1.05e-8 Parkinson's disease; CRC cis rs11122272 0.735 rs2739513 chr1:231515201 C/T cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.54 -8.15 -0.41 7.95e-15 Hemoglobin concentration; CRC cis rs10504229 0.954 rs903717 chr8:58167856 A/G cg02725872 chr8:58115012 NA -0.41 -8.22 -0.41 4.62e-15 Developmental language disorder (linguistic errors); CRC cis rs2832191 0.791 rs9983651 chr21:30491227 T/A cg08807101 chr21:30365312 RNF160 -0.63 -9.93 -0.48 1.74e-20 Dental caries; CRC cis rs2404602 0.710 rs2469541 chr15:76562118 C/T cg23625390 chr15:77176239 SCAPER -0.46 -6.92 -0.36 2.43e-11 Blood metabolite levels; CRC cis rs4843747 0.671 rs72818577 chr16:88111181 G/A cg03395651 chr16:88107091 BANP 0.57 7.76 0.39 1.1e-13 Menopause (age at onset); CRC cis rs7119 0.651 rs12904533 chr15:77845928 G/A cg10437265 chr15:77819839 NA 0.6 9.97 0.48 1.21e-20 Type 2 diabetes; CRC cis rs1799949 1.000 rs12516 chr17:41196408 G/A cg01879757 chr17:41196368 BRCA1 -0.41 -6.21 -0.32 1.63e-9 Menopause (age at onset); CRC cis rs9311474 0.507 rs4687644 chr3:52746541 T/G cg18099408 chr3:52552593 STAB1 -0.46 -7.71 -0.39 1.48e-13 Electroencephalogram traits; CRC cis rs10971721 0.908 rs10971722 chr9:33828164 G/A cg13495928 chr9:33750294 PRSS3 0.55 5.93 0.31 7.7e-9 Body mass index; CRC cis rs11098499 0.863 rs1383533 chr4:120434576 G/A cg09307838 chr4:120376055 NA 0.69 10.46 0.5 2.77e-22 Corneal astigmatism; CRC cis rs11025559 0.796 rs10833317 chr11:20412277 A/T cg19653624 chr11:20408972 PRMT3 -0.66 -7.93 -0.4 3.35e-14 Pursuit maintenance gain; CRC cis rs3741404 0.620 rs12787945 chr11:63977546 G/A cg14078730 chr11:63896557 MACROD1 0.35 5.61 0.3 4.34e-8 Platelet count; CRC cis rs873946 0.586 rs2001426 chr10:134563871 G/A cg18305652 chr10:134549665 INPP5A 0.49 6.24 0.33 1.38e-9 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CRC cis rs11711311 0.955 rs12630791 chr3:113387717 C/T cg15478005 chr3:113465772 ATP6V1A;NAA50 -0.43 -5.84 -0.31 1.29e-8 IgG glycosylation; CRC cis rs10504229 0.728 rs17215851 chr8:58154160 A/C cg21724239 chr8:58056113 NA 0.62 8.38 0.42 1.51e-15 Developmental language disorder (linguistic errors); CRC cis rs12325245 0.536 rs12924708 chr16:58567643 G/A cg01472538 chr16:58549086 SETD6 1.03 6.64 0.34 1.3100000000000001e-10 Schizophrenia; CRC cis rs3936840 0.964 rs10150698 chr14:102977876 A/G cg18135206 chr14:102964638 TECPR2 0.54 7.83 0.4 6.89e-14 Plateletcrit; CRC cis rs7659604 1.000 rs35901586 chr4:122664757 T/A cg06713675 chr4:122721982 EXOSC9 -0.38 -6.19 -0.32 1.76e-9 Type 2 diabetes; CRC cis rs651907 0.535 rs13084113 chr3:101534039 C/G cg12386194 chr3:101231763 SENP7 0.5 7.14 0.37 6.18e-12 Colorectal cancer; CRC cis rs9467711 0.606 rs71557334 chr6:26365913 G/T cg14345882 chr6:26364793 BTN3A2 0.65 5.74 0.3 2.17e-8 Autism spectrum disorder or schizophrenia; CRC cis rs972578 0.837 rs3788601 chr22:43327526 C/T cg01576275 chr22:43409880 NA -0.38 -6.05 -0.32 4e-9 Mean platelet volume; CRC trans rs3960554 0.867 rs10239209 chr7:75804085 G/A cg19862616 chr7:65841803 NCRNA00174 0.64 7.57 0.39 3.9e-13 Eotaxin levels; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg20336580 chr22:19166301 SLC25A1 0.4 6.33 0.33 7.98e-10 Intelligence (multi-trait analysis); CRC cis rs2730260 0.537 rs73169238 chr7:158883818 G/A cg02254261 chr7:158964346 NA -0.54 -6.19 -0.32 1.8e-9 Myopia (pathological); CRC cis rs9287719 0.624 rs10187659 chr2:10726960 C/T cg00105475 chr2:10696890 NA 0.44 7.0 0.36 1.43e-11 Prostate cancer; CRC cis rs4665809 0.627 rs13014338 chr2:26463024 C/T cg08067268 chr2:26466485 HADHB;HADHA 0.65 8.34 0.42 2e-15 Gut microbiome composition (summer); CRC cis rs7123876 0.830 rs59311588 chr11:72435996 A/G cg04827223 chr11:72435913 ARAP1 -0.54 -7.49 -0.38 6.31e-13 Body mass index; CRC trans rs3733585 0.781 rs57250714 chr4:9984529 C/T cg26043149 chr18:55253948 FECH 0.51 7.79 0.39 8.59e-14 Cleft plate (environmental tobacco smoke interaction); CRC cis rs2882667 0.931 rs10069528 chr5:138354027 A/G cg09476006 chr5:138032270 NA 0.41 6.83 0.35 4.08e-11 Age-related hearing impairment (SNP x SNP interaction); CRC trans rs2303319 0.504 rs56009150 chr2:162598582 T/C cg25193742 chr10:104614220 C10orf32 -0.76 -6.42 -0.33 4.8e-10 Cognitive function; CRC cis rs684232 0.666 rs423887 chr17:593600 A/G cg15660573 chr17:549704 VPS53 -0.8 -12.44 -0.57 2.23e-29 Prostate cancer; CRC cis rs2739330 0.789 rs5760109 chr22:24252938 C/G cg10150615 chr22:24372951 LOC391322 -0.62 -9.48 -0.46 5.4e-19 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs4665809 0.589 rs4665842 chr2:26448954 A/G cg27170947 chr2:26402098 FAM59B -0.59 -7.68 -0.39 1.84e-13 Gut microbiome composition (summer); CRC cis rs6060717 0.654 rs8122716 chr20:34607001 C/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.45 -6.64 -0.34 1.27e-10 Hip circumference adjusted for BMI; CRC cis rs9443645 0.901 rs1572584 chr6:79690290 A/G cg11833968 chr6:79620685 NA 0.35 5.96 0.31 6.48e-9 Intelligence (multi-trait analysis); CRC cis rs11190604 1.000 rs10883496 chr10:102221931 T/C cg16342193 chr10:102329863 NA -0.37 -6.1 -0.32 2.96e-9 Palmitoleic acid (16:1n-7) levels; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg08664652 chr17:28804287 GOSR1 0.46 6.0 0.31 5.25e-9 Thyroid stimulating hormone; CRC cis rs17376456 0.809 rs12152763 chr5:93405509 T/A cg09848695 chr5:92956644 FAM172A;MIR2277 0.64 5.88 0.31 1.03e-8 Diabetic retinopathy; CRC cis rs55702914 0.628 rs6745660 chr2:198349536 A/G cg10820045 chr2:198174542 NA 0.33 5.89 0.31 9.78e-9 Major depression and alcohol dependence; CRC cis rs9462846 0.853 rs9296401 chr6:42875465 A/G cg21280719 chr6:42927975 GNMT -0.33 -6.26 -0.33 1.21e-9 Blood protein levels; CRC cis rs55788414 1.000 rs35769936 chr16:81180101 A/G cg06400318 chr16:81190750 PKD1L2 -0.68 -6.38 -0.33 5.87e-10 Left ventricular obstructive tract defect (maternal effect); CRC cis rs9487051 0.872 rs9487043 chr6:109610474 C/T cg12927641 chr6:109611667 NA -0.39 -6.98 -0.36 1.59e-11 Reticulocyte fraction of red cells; CRC cis rs9649213 0.574 rs62479853 chr7:97917158 G/T cg24562669 chr7:97807699 LMTK2 0.46 7.82 0.4 7.01e-14 Prostate cancer (SNP x SNP interaction); CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg07466433 chr2:7005728 CMPK2 -0.43 -6.31 -0.33 8.79e-10 Myopia (pathological); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg02470736 chr12:50505862 C12orf62 0.4 6.23 0.32 1.42e-9 Intelligence (multi-trait analysis); CRC trans rs1941687 0.509 rs2282632 chr18:31320229 A/G cg27147174 chr7:100797783 AP1S1 -0.37 -6.24 -0.33 1.31e-9 Subjective well-being (multi-trait analysis);Subjective well-being; CRC cis rs12477438 0.798 rs4850891 chr2:99574642 A/G cg14399236 chr2:99771627 LIPT1;TSGA10 -0.7 -9.73 -0.47 8.17e-20 Chronic sinus infection; CRC cis rs9894429 0.621 rs9747119 chr17:79607017 A/G cg09655341 chr17:79618100 PDE6G -0.36 -6.11 -0.32 2.75e-9 Eye color traits; CRC cis rs853679 0.546 rs200950 chr6:27835772 A/G cg19041857 chr6:27730383 NA -0.71 -6.71 -0.35 8.65e-11 Depression; CRC cis rs9811920 0.695 rs793497 chr3:99505610 T/C cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G -0.43 -6.02 -0.31 4.78e-9 Axial length; CRC cis rs1129187 0.791 rs1129186 chr6:42932202 C/T cg27588902 chr6:42928151 GNMT -0.4 -7.39 -0.38 1.19e-12 Alzheimer's disease in APOE e4+ carriers; CRC cis rs34779708 0.931 rs59418206 chr10:35331624 G/A cg03585969 chr10:35415529 CREM 0.67 8.91 0.44 3.47e-17 Inflammatory bowel disease;Crohn's disease; CRC cis rs1580019 0.510 rs4723162 chr7:32543804 C/A cg14728415 chr7:32535168 LSM5;AVL9 0.45 6.46 0.34 3.83e-10 Cognitive ability; CRC cis rs11191205 0.865 rs11191161 chr10:103726528 C/T cg15320455 chr10:103880129 LDB1 -0.63 -6.85 -0.35 3.7e-11 Intelligence (multi-trait analysis); CRC cis rs6951245 0.572 rs112072378 chr7:1039400 C/T cg21664854 chr7:1097933 C7orf50;GPR146 0.77 5.99 0.31 5.63e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs11785693 0.865 rs11784227 chr8:4970485 A/C cg26367366 chr8:4980734 NA 0.76 9.2 0.45 4.29e-18 Neuroticism (multi-trait analysis);Neuroticism; CRC cis rs1005277 0.579 rs2474586 chr10:38418882 T/C cg25427524 chr10:38739819 LOC399744 -0.77 -13.56 -0.6 1.36e-33 Extrinsic epigenetic age acceleration; CRC cis rs4664293 0.867 rs2114626 chr2:160639970 C/T cg08347373 chr2:160653686 CD302 0.46 7.37 0.38 1.4e-12 Monocyte percentage of white cells; CRC cis rs3796352 1.000 rs11718538 chr3:52975987 C/G cg27565382 chr3:53032988 SFMBT1 0.7 6.16 0.32 2.07e-9 Immune reponse to smallpox (secreted IL-2); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg13881405 chr9:92220388 GADD45G 0.4 5.98 0.31 5.9e-9 Intelligence (multi-trait analysis); CRC trans rs1814175 0.529 rs10839396 chr11:49852406 G/T cg11707556 chr5:10655725 ANKRD33B 0.47 7.7 0.39 1.58e-13 Height; CRC cis rs2949837 0.581 rs2949838 chr7:45993924 T/C cg23193639 chr7:45961078 IGFBP3 0.41 6.97 0.36 1.7e-11 Sitting height ratio; CRC cis rs16973500 0.711 rs2878491 chr16:71981218 T/G cg00732059 chr16:71740210 PHLPP2 -0.65 -6.76 -0.35 6.38e-11 Response to anti-TNF therapy in rheumatoid arthritis;Attention deficit hyperactivity disorder and conduct disorder; CRC trans rs9398803 0.650 rs10499135 chr6:126626333 A/G cg14379719 chr8:11561508 GATA4 0.38 6.09 0.32 3.08e-9 Male-pattern baldness; CRC cis rs1005224 0.926 rs7143743 chr14:76127805 G/C cg04684003 chr14:76127793 TTLL5;C14orf1 -0.56 -7.77 -0.39 1.04e-13 Large artery stroke; CRC cis rs3733585 0.673 rs6836706 chr4:9964251 T/A cg00071950 chr4:10020882 SLC2A9 -0.54 -9.65 -0.47 1.42e-19 Cleft plate (environmental tobacco smoke interaction); CRC cis rs1448094 0.512 rs6539929 chr12:86244932 T/C cg02569458 chr12:86230093 RASSF9 0.42 7.2 0.37 4.01e-12 Major depressive disorder; CRC cis rs868943 0.511 rs12204724 chr6:116532430 C/T cg26893134 chr6:116381904 FRK 0.23 5.64 0.3 3.62e-8 Total cholesterol levels; CRC cis rs780096 0.506 rs2303369 chr2:27715416 C/T cg12000995 chr2:27665139 KRTCAP3 -0.32 -6.37 -0.33 6.46e-10 Total body bone mineral density; CRC cis rs10971721 0.822 rs56172788 chr9:33865750 A/G cg13495928 chr9:33750294 PRSS3 0.56 5.95 0.31 6.96e-9 Body mass index; CRC cis rs514406 0.861 rs7417821 chr1:53295117 A/G cg08859206 chr1:53392774 SCP2 -0.43 -7.0 -0.36 1.47e-11 Monocyte count; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg14045725 chr17:2240967 SGSM2;TSR1 0.47 7.04 0.36 1.11e-11 Response to antipsychotic treatment; CRC trans rs2303319 0.504 rs62189055 chr2:162625749 C/A cg16699849 chr7:98923489 ARPC1A -0.68 -6.2 -0.32 1.66e-9 Cognitive function; CRC cis rs7666738 0.753 rs10004827 chr4:99037953 A/C cg17366294 chr4:99064904 C4orf37 0.44 7.5 0.38 6.02e-13 Colonoscopy-negative controls vs population controls; CRC trans rs4352210 0.929 rs10084269 chr2:37761211 A/T cg13134662 chr9:136858680 VAV2 -0.41 -5.99 -0.31 5.46e-9 RR interval (heart rate); CRC cis rs1448094 0.511 rs2405623 chr12:86153466 G/A cg18827107 chr12:86230957 RASSF9 0.38 5.93 0.31 7.83e-9 Major depressive disorder; CRC trans rs73162807 0.655 rs6775587 chr3:146446783 A/T cg26896787 chr1:228603707 TRIM17 -0.59 -5.99 -0.31 5.61e-9 Platelet-derived growth factor BB levels; CRC cis rs4700695 0.719 rs27584 chr5:65445232 G/A cg21114390 chr5:65439923 SFRS12 -0.64 -8.71 -0.43 1.45e-16 Facial morphology (factor 19); CRC cis rs875971 0.792 rs6971752 chr7:65737986 G/A cg00343986 chr7:65444356 GUSB -0.4 -5.62 -0.3 4.07e-8 Aortic root size; CRC trans rs1455244 0.700 rs7229302 chr18:11508904 G/T cg09961100 chr19:5978428 RANBP3 0.39 6.12 0.32 2.61e-9 Schizophrenia; CRC cis rs4629180 0.959 rs11896771 chr2:102098328 T/C cg01388757 chr2:102091195 RFX8 -0.54 -7.75 -0.39 1.12e-13 Chronic rhinosinusitis with nasal polyps; CRC cis rs926938 0.584 rs1286558 chr1:115357587 C/T cg12756093 chr1:115239321 AMPD1 0.58 8.79 0.44 8.71e-17 Autism; CRC trans rs1814175 0.702 rs4881644 chr11:49786367 C/T cg15704280 chr7:45808275 SEPT13 -0.97 -18.79 -0.72 5.11e-54 Height; CRC cis rs8018808 1.000 rs4903580 chr14:77850978 C/T cg20045696 chr14:77926864 AHSA1 -0.35 -5.6 -0.3 4.45e-8 Myeloid white cell count; CRC cis rs951366 0.903 rs823116 chr1:205720483 G/A cg07157834 chr1:205819609 PM20D1 0.46 6.84 0.35 3.79e-11 Menarche (age at onset); CRC cis rs1572438 0.868 rs9378518 chr6:861084 A/G cg21062780 chr6:887772 NA -0.35 -5.62 -0.3 4.02e-8 Aging; CRC cis rs597539 0.652 rs507520 chr11:68666054 C/T cg06028808 chr11:68637592 NA 0.4 6.27 0.33 1.13e-9 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs514406 0.861 rs505444 chr1:53251860 C/T cg08859206 chr1:53392774 SCP2 -0.43 -6.64 -0.34 1.28e-10 Monocyte count; CRC cis rs35306767 0.953 rs10904583 chr10:983498 T/C cg26597838 chr10:835615 NA 0.77 9.7 0.47 9.7e-20 Eosinophil percentage of granulocytes; CRC cis rs9859260 0.744 rs557527 chr3:195780709 G/A cg12923728 chr3:195709715 SDHAP1 0.47 6.42 0.33 4.86e-10 Mean corpuscular volume; CRC cis rs10924970 0.649 rs4412584 chr1:235418146 T/C cg09010748 chr1:235293032 TOMM20 -0.41 -5.65 -0.3 3.48e-8 Asthma; CRC cis rs9787249 0.957 rs7547787 chr1:40220806 C/T cg01941586 chr1:40203715 PPIE -0.42 -5.86 -0.31 1.14e-8 Blood protein levels; CRC cis rs3015497 0.616 rs1389650 chr14:51081449 C/T cg09863266 chr14:51125203 SAV1 -0.31 -5.77 -0.3 1.79e-8 Mean platelet volume; CRC cis rs1538970 1.000 rs2050884 chr1:45830824 A/G cg05343316 chr1:45956843 TESK2 0.63 8.69 0.43 1.69e-16 Platelet count; CRC cis rs8064299 0.655 rs895691 chr17:72766300 G/T cg25054828 chr17:72772726 NAT9;TMEM104 0.64 9.88 0.48 2.42e-20 Monocyte count; CRC cis rs2535633 0.631 rs2581803 chr3:52994981 G/A cg15147215 chr3:52552868 STAB1 0.42 6.76 0.35 6.46e-11 Body mass index; CRC cis rs9534288 0.797 rs7996875 chr13:46612836 C/T cg15192986 chr13:46630673 CPB2 0.68 9.73 0.47 7.8500000000000006e-20 Blood protein levels; CRC cis rs7659604 0.539 rs7699776 chr4:122753885 A/G cg20573242 chr4:122745356 CCNA2 0.59 8.85 0.44 5.52e-17 Type 2 diabetes; CRC cis rs3736594 0.513 rs62138966 chr2:27819172 G/A cg27432699 chr2:27873401 GPN1 0.63 8.03 0.41 1.69e-14 Fasting blood glucose;Fasting blood glucose (BMI interaction); CRC cis rs7927592 0.871 rs12941 chr11:68382193 C/T cg01657329 chr11:68192670 LRP5 -0.46 -6.61 -0.34 1.51e-10 Total body bone mineral density; CRC cis rs2836974 0.739 rs12482181 chr21:40548852 A/G cg17971929 chr21:40555470 PSMG1 0.81 11.54 0.54 4.38e-26 Cognitive function; CRC cis rs9768139 0.708 rs921615 chr7:158117935 A/G cg24154853 chr7:158122151 PTPRN2 0.64 10.59 0.5 9.21e-23 Calcium levels; CRC cis rs7258465 1.000 rs76194 chr19:18630580 T/G cg06462663 chr19:18546047 ISYNA1 0.5 7.63 0.39 2.48e-13 Breast cancer; CRC cis rs10426930 0.671 rs57900491 chr19:4995295 A/T cg25246084 chr19:4971487 KDM4B -0.36 -5.95 -0.31 6.8e-9 Monocyte percentage of white cells; CRC cis rs9303280 0.901 rs9303277 chr17:37976469 C/T cg11212589 chr17:38028394 ZPBP2 0.44 8.38 0.42 1.51e-15 Self-reported allergy; CRC cis rs1179624 0.679 rs4731244 chr7:75267614 A/G cg05145297 chr7:75264568 HIP1 0.62 8.59 0.43 3.66e-16 Age-related nuclear cataracts; CRC cis rs5753618 0.539 rs2228619 chr22:31663842 C/G cg07713946 chr22:31675144 LIMK2 -0.4 -5.73 -0.3 2.24e-8 Colorectal cancer; CRC cis rs7666738 0.830 rs17550735 chr4:99014076 T/G cg05340658 chr4:99064831 C4orf37 0.62 9.64 0.47 1.5700000000000001e-19 Colonoscopy-negative controls vs population controls; CRC trans rs9747201 1.000 rs58119191 chr17:80155329 T/C cg07393940 chr7:158741817 NA 0.51 7.38 0.38 1.34e-12 Peripheral arterial disease (traffic-related air pollution interaction); CRC trans rs637571 0.522 rs538954 chr11:65756808 A/G cg17712092 chr4:129076599 LARP1B 0.68 11.48 0.53 6.79e-26 Eosinophil percentage of white cells; CRC cis rs7618915 0.501 rs10865974 chr3:52718280 A/C cg11645453 chr3:52864694 ITIH4 -0.36 -6.44 -0.33 4.27e-10 Bipolar disorder; CRC trans rs6076960 0.684 rs3852949 chr20:6264758 T/A cg21095983 chr6:86352623 SYNCRIP 0.58 8.32 0.42 2.43e-15 Smooth-surface caries; CRC trans rs57221529 0.664 rs72704802 chr5:554211 C/T cg11887960 chr12:57824829 NA 0.58 6.29 0.33 1.02e-9 Lung disease severity in cystic fibrosis; CRC cis rs9660992 0.547 rs12143121 chr1:205199142 A/G cg03948781 chr1:205179583 DSTYK 0.41 5.65 0.3 3.49e-8 Mean corpuscular volume;Mean platelet volume; CRC cis rs965469 1.000 rs6051716 chr20:3267736 C/T cg25506879 chr20:3388711 C20orf194 -0.4 -5.64 -0.3 3.74e-8 IFN-related cytopenia; CRC cis rs7223966 1.000 rs55674647 chr17:61794195 T/C cg23090583 chr17:61904693 PSMC5;FTSJ3 0.56 6.44 0.33 4.13e-10 Hip circumference adjusted for BMI;Body mass index; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg01664094 chr15:75748568 SIN3A 0.43 6.15 0.32 2.2e-9 Response to antipsychotic treatment; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg11109510 chr2:170655290 SSB 0.4 5.97 0.31 6.16e-9 Liver disease severity in Alagille syndrome; CRC cis rs870825 0.616 rs12512839 chr4:185610347 G/A cg07424746 chr4:185654737 MLF1IP -0.57 -5.69 -0.3 2.79e-8 Blood protein levels; CRC cis rs7605827 0.930 rs6431712 chr2:15691292 C/T cg19274914 chr2:15703543 NA 0.39 5.82 0.31 1.4e-8 Educational attainment (years of education); CRC cis rs9534288 0.699 rs4280137 chr13:46664008 G/A cg15192986 chr13:46630673 CPB2 -0.65 -8.76 -0.44 1.02e-16 Blood protein levels; CRC cis rs10504229 0.517 rs75486476 chr8:58056079 G/T cg11062466 chr8:58055876 NA 0.58 10.29 0.49 9.89e-22 Developmental language disorder (linguistic errors); CRC cis rs2404602 0.631 rs9646213 chr15:76807672 G/C cg23625390 chr15:77176239 SCAPER 0.51 7.29 0.37 2.31e-12 Blood metabolite levels; CRC trans rs877282 0.853 rs11593836 chr10:756715 G/A cg22713356 chr15:30763199 NA 1.19 13.88 0.61 8.17e-35 Uric acid levels; CRC cis rs6540559 0.673 rs11805830 chr1:209984969 C/T cg21951975 chr1:209979733 IRF6 0.48 6.54 0.34 2.34e-10 Cleft lip with or without cleft palate; CRC cis rs17345786 0.906 rs55710435 chr3:101180330 G/A cg12386194 chr3:101231763 SENP7 0.56 7.29 0.37 2.35e-12 Colonoscopy-negative controls vs population controls; CRC cis rs13064447 0.789 rs55976129 chr3:12762067 T/C cg07775309 chr3:12595852 NA 0.37 5.94 0.31 7.18e-9 Major depression and alcohol dependence; CRC cis rs4664293 0.801 rs6432552 chr2:160574124 A/T cg08347373 chr2:160653686 CD302 -0.35 -5.62 -0.3 4.15e-8 Monocyte percentage of white cells; CRC cis rs2404602 1.000 rs12594212 chr15:76802014 T/A cg23625390 chr15:77176239 SCAPER 0.6 9.3 0.46 1.98e-18 Blood metabolite levels; CRC cis rs9303280 0.806 rs2872507 chr17:38040763 C/T cg11212589 chr17:38028394 ZPBP2 0.41 7.59 0.39 3.24e-13 Self-reported allergy; CRC cis rs7512552 0.839 rs11590787 chr1:150398531 G/A cg15654264 chr1:150340011 RPRD2 0.58 8.5 0.42 6.79e-16 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); CRC cis rs3741151 1.000 rs75109191 chr11:73023532 T/C cg17517138 chr11:73019481 ARHGEF17 1.13 10.09 0.49 4.97e-21 GIP levels in response to oral glucose tolerance test (120 minutes); CRC trans rs12714314 0.560 rs11694545 chr2:1939208 C/T cg25508545 chr19:49467065 FTL 0.42 5.99 0.31 5.59e-9 Type 2 diabetes (age of onset); CRC cis rs10504229 0.953 rs6990806 chr8:58183113 G/A cg02725872 chr8:58115012 NA -0.38 -6.43 -0.33 4.44e-10 Developmental language disorder (linguistic errors); CRC cis rs2836950 0.840 rs12482317 chr21:40588241 A/G cg17971929 chr21:40555470 PSMG1 -0.49 -6.29 -0.33 9.87e-10 Menarche (age at onset); CRC cis rs2012796 0.956 rs6574646 chr14:81819809 A/G cg02996355 chr14:81879375 NA 0.5 7.37 0.38 1.37e-12 Night sleep phenotypes; CRC trans rs7824557 1.000 rs2736371 chr8:11105529 A/G cg06636001 chr8:8085503 FLJ10661 -0.49 -6.79 -0.35 5.28e-11 Retinal vascular caliber; CRC cis rs7605827 0.930 rs1990755 chr2:15616013 C/G cg19274914 chr2:15703543 NA 0.39 5.9 0.31 8.83e-9 Educational attainment (years of education); CRC cis rs9811920 0.638 rs793471 chr3:99546335 A/C cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G -0.45 -6.01 -0.31 5.03e-9 Axial length; CRC trans rs1814175 0.509 rs60698301 chr11:49877672 G/A cg03929089 chr4:120376271 NA -0.9 -15.52 -0.65 3.9e-41 Height; CRC cis rs66731853 0.769 rs477679 chr1:20894618 A/G cg04087271 chr1:20915334 CDA 0.42 6.95 0.36 1.96e-11 Mean corpuscular volume; CRC cis rs9616064 0.704 rs41346347 chr22:46958507 A/C cg05621596 chr22:47072043 GRAMD4 -0.57 -8.88 -0.44 4.32e-17 Urate levels in obese individuals; CRC cis rs910316 0.591 rs7157158 chr14:75457238 A/G cg08847533 chr14:75593920 NEK9 0.84 14.53 0.63 2.7e-37 Height; CRC cis rs801193 0.773 rs801207 chr7:66020590 T/C cg18876405 chr7:65276391 NA -0.59 -10.53 -0.5 1.57e-22 Aortic root size; CRC cis rs1348850 0.608 rs10176632 chr2:178225934 G/T cg02961200 chr2:178257176 LOC100130691;AGPS 0.4 5.66 0.3 3.22e-8 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs7615952 0.599 rs1044215 chr3:125725559 C/G cg02772935 chr3:125709198 NA -0.46 -5.98 -0.31 5.91e-9 Blood pressure (smoking interaction); CRC cis rs6570726 0.846 rs411468 chr6:145832792 A/G cg05347473 chr6:146136440 FBXO30 0.37 6.0 0.31 5.27e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs1862618 0.620 rs189695 chr5:56225769 T/C cg12311346 chr5:56204834 C5orf35 -0.66 -9.78 -0.47 5.53e-20 Initial pursuit acceleration; CRC cis rs1816752 0.870 rs7320102 chr13:25011573 T/C cg02811702 chr13:24901961 NA 0.47 6.56 0.34 2.09e-10 Obesity-related traits; CRC cis rs78456975 1.000 rs11884854 chr2:1566154 A/G cg26248373 chr2:1572462 NA -0.7 -8.06 -0.41 1.47e-14 Placebo response in major depressive disorder (% change in symptom score); CRC cis rs11212617 0.967 rs186594 chr11:108265854 A/T cg01991180 chr11:108092276 ATM;NPAT 0.43 6.34 0.33 7.41e-10 Response to metformin in type 2 diabetes (glycemic); CRC cis rs6952808 0.689 rs871924 chr7:2047845 A/G cg02951883 chr7:2050386 MAD1L1 -0.74 -12.28 -0.56 8.36e-29 Bipolar disorder and schizophrenia; CRC cis rs7085104 0.660 rs3781286 chr10:104595719 C/T cg23093090 chr10:104574429 C10orf26 -0.37 -6.04 -0.32 4.18e-9 Immature fraction of reticulocytes;Schizophrenia; CRC cis rs1799949 0.930 rs3765640 chr17:41276247 A/G cg19454999 chr17:41278357 BRCA1;NBR2 0.55 8.63 0.43 2.68e-16 Menopause (age at onset); CRC cis rs459193 1.000 rs40271 chr5:55796319 A/G cg18302225 chr5:55776401 NA -0.59 -8.74 -0.43 1.21e-16 Coronary artery disease;Type 2 diabetes;Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);Waist-to-hip ratio adjusted for BMI in non-smokers;Waist-to-hip ratio adjusted for BMI (smoking interaction);Waist-to-hip ratio adjusted for body mass index;Waist-hip ratio;Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction); CRC cis rs28655083 0.529 rs1485794 chr16:77101977 A/G cg01753188 chr16:77233325 SYCE1L;MON1B 0.48 6.74 0.35 7.26e-11 Lobe attachment (rater-scored or self-reported); CRC cis rs2737618 0.651 rs2249156 chr1:200083541 A/G cg21825944 chr1:200113062 NR5A2 0.5 7.42 0.38 1.03e-12 Uric acid levels; CRC cis rs950776 0.518 rs55690619 chr15:78833612 A/G cg06917634 chr15:78832804 PSMA4 -0.67 -10.68 -0.51 4.84e-23 Sudden cardiac arrest; CRC cis rs950169 0.920 rs17300048 chr15:84749477 C/T cg03959625 chr15:84868606 LOC388152 0.41 6.07 0.32 3.55e-9 Schizophrenia; CRC trans rs853679 0.599 rs149943 chr6:28002388 G/A cg06606381 chr12:133084897 FBRSL1 -0.8 -7.5 -0.38 6.11e-13 Depression; CRC cis rs35306767 0.761 rs1871621 chr10:1049596 C/T cg20503657 chr10:835505 NA 0.93 11.11 0.52 1.43e-24 Eosinophil percentage of granulocytes; CRC cis rs35306767 0.715 rs1250891 chr10:1040159 G/C cg20503657 chr10:835505 NA 0.94 11.14 0.52 1.1e-24 Eosinophil percentage of granulocytes; CRC cis rs2624839 0.704 rs2624833 chr3:50212512 G/T cg05623727 chr3:50126028 RBM5 0.41 6.32 0.33 8.31e-10 Intelligence (multi-trait analysis); CRC cis rs4713118 0.869 rs9295743 chr6:27715102 G/C cg20933634 chr6:27740509 NA 0.58 8.63 0.43 2.69e-16 Parkinson's disease; CRC cis rs3540 0.960 rs8040585 chr15:91026477 T/C cg22089800 chr15:90895588 ZNF774 0.49 7.91 0.4 3.9e-14 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; CRC cis rs1008375 1.000 rs6849704 chr4:17652031 G/C cg04450456 chr4:17643702 FAM184B 0.41 6.7 0.35 8.83e-11 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs1256061 0.646 rs1256056 chr14:64712626 A/G cg23250157 chr14:64679961 SYNE2 0.4 6.28 0.33 1.09e-9 Hemoglobin concentration;Red blood cell count;Hematocrit; CRC cis rs41005 1.000 rs41004 chr2:8111580 C/T cg03155496 chr2:8117019 LOC339788 0.4 7.11 0.36 7.35e-12 Response to anti-TNF therapy in rheumatoid arthritis; CRC cis rs6951245 0.572 rs60918895 chr7:1039036 C/T cg26224354 chr7:1096374 C7orf50;GPR146 -0.87 -8.07 -0.41 1.35e-14 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs1555322 0.530 rs2425042 chr20:33865895 G/A cg08210727 chr20:33865349 NA 0.49 6.15 0.32 2.19e-9 Attention deficit hyperactivity disorder; CRC trans rs12517041 1.000 rs34157151 chr5:23289755 C/T ch.8.1293020R chr8:59333349 UBXN2B -0.55 -6.17 -0.32 2.05e-9 Calcium levels; CRC cis rs13118159 0.771 rs13117476 chr4:1334721 A/G cg02018176 chr4:1364513 KIAA1530 0.4 6.42 0.33 4.67e-10 Longevity; CRC cis rs10781543 0.845 rs35763810 chr9:139323799 A/G cg14169450 chr9:139327907 INPP5E 0.36 5.67 0.3 3.21e-8 Monocyte percentage of white cells; CRC trans rs2797160 1.000 rs2211418 chr6:125995503 G/A cg05039488 chr6:79577232 IRAK1BP1 -0.47 -6.89 -0.36 2.8e-11 Endometrial cancer; CRC cis rs3760982 0.565 rs8104300 chr19:44293144 T/C cg11993925 chr19:44307056 LYPD5 0.56 9.98 0.48 1.18e-20 Breast cancer (estrogen-receptor negative);Breast cancer; CRC cis rs3749237 0.576 rs3877784 chr3:49539417 C/T cg02487422 chr3:49467188 NICN1 0.44 7.06 0.36 9.87e-12 Resting heart rate; CRC cis rs2380220 0.808 rs2613553 chr6:95916704 A/G cg04719120 chr6:96025338 MANEA -0.53 -5.86 -0.31 1.14e-8 Behavioural disinhibition (generation interaction); CRC trans rs4843747 0.619 rs66508972 chr16:88086385 C/G cg26811252 chr16:29126840 RRN3P2 0.72 9.81 0.48 4.4e-20 Menopause (age at onset); CRC cis rs12200560 0.505 rs984519 chr6:97076223 A/G cg06623918 chr6:96969491 KIAA0776 -0.48 -7.07 -0.36 9.1e-12 Coronary heart disease; CRC cis rs2795502 0.506 rs11819501 chr10:43465544 C/T cg08461752 chr10:43522343 NA -0.68 -6.35 -0.33 7.15e-10 Blood protein levels; CRC cis rs2982552 0.873 rs3020305 chr6:152064487 T/C cg22157087 chr6:152012887 ESR1 0.38 5.81 0.3 1.5e-8 Bone properties (heel); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg11568364 chr10:126432734 FAM53B 0.42 6.21 0.32 1.59e-9 Intelligence (multi-trait analysis); CRC cis rs422249 0.512 rs174554 chr11:61579463 A/G cg06781209 chr11:61594997 FADS2 -0.38 -5.74 -0.3 2.11e-8 Trans fatty acid levels; CRC cis rs860295 0.702 rs10908470 chr1:155527013 A/C cg02153340 chr1:155202674 NA -0.53 -6.35 -0.33 7.32e-10 Body mass index; CRC cis rs3617 0.539 rs4687689 chr3:52948674 A/C cg11645453 chr3:52864694 ITIH4 -0.39 -7.66 -0.39 2.04e-13 Red blood cell count;Autism spectrum disorder or schizophrenia; CRC cis rs13064411 0.696 rs6787026 chr3:113162117 A/G cg18753928 chr3:113234510 CCDC52 -0.64 -8.47 -0.42 8.04e-16 Response to simvastatin treatment (PCSK9 protein level change); CRC cis rs7264396 0.790 rs6060539 chr20:34239382 C/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.62 -10.4 -0.5 4.29e-22 Total cholesterol levels; CRC cis rs4862750 0.872 rs6836781 chr4:187899701 G/A cg11301795 chr4:187892539 NA -0.87 -20.32 -0.75 4.87e-60 Lobe attachment (rater-scored or self-reported); CRC cis rs514406 0.698 rs576891 chr1:53364976 A/G cg24675658 chr1:53192096 ZYG11B -0.68 -9.89 -0.48 2.36e-20 Monocyte count; CRC cis rs9818758 0.607 rs11716445 chr3:49406095 C/T cg07636037 chr3:49044803 WDR6 -0.81 -5.89 -0.31 9.62e-9 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; CRC cis rs875971 0.862 rs6964437 chr7:65686444 A/G cg18876405 chr7:65276391 NA -0.54 -8.69 -0.43 1.74e-16 Aortic root size; CRC trans rs57221529 0.709 rs72703090 chr5:598314 C/T cg25482853 chr8:67687455 SGK3 1.09 12.84 0.58 7.36e-31 Lung disease severity in cystic fibrosis; CRC cis rs1506636 0.924 rs2402668 chr7:123296605 T/A cg03229431 chr7:123269106 ASB15 -0.78 -12.46 -0.57 1.92e-29 Plateletcrit;Platelet count; CRC cis rs2836974 0.931 rs2735306 chr21:40713134 A/G cg06238570 chr21:40685208 BRWD1 -0.68 -9.11 -0.45 8e-18 Cognitive function; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg12703194 chr16:3086867 CCDC64B -0.38 -6.02 -0.31 4.53e-9 Myopia (pathological); CRC cis rs12451471 0.637 rs12950757 chr17:78096800 T/G cg18972013 chr17:78078605 GAA -0.41 -5.8 -0.3 1.53e-8 Plateletcrit;Mean corpuscular hemoglobin concentration; CRC cis rs6761276 0.674 rs3811056 chr2:113831183 T/C cg09040174 chr2:113837401 NA 0.43 5.79 0.3 1.64e-8 Protein quantitative trait loci; CRC cis rs7584330 0.518 rs74003106 chr2:238447004 A/G cg14458575 chr2:238380390 NA 0.7 8.62 0.43 2.8e-16 Prostate cancer; CRC cis rs9937943 0.667 rs12934000 chr16:74623420 T/G cg01733217 chr16:74700730 RFWD3 0.71 8.03 0.4 1.76e-14 Neutrophil percentage of white cells; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg21287330 chr17:7154245 C17orf81;DULLARD 0.39 6.06 0.32 3.68e-9 Intelligence (multi-trait analysis); CRC cis rs7666738 0.830 rs7689495 chr4:98920152 T/C cg05340658 chr4:99064831 C4orf37 0.6 9.23 0.45 3.31e-18 Colonoscopy-negative controls vs population controls; CRC cis rs9916302 0.752 rs8071300 chr17:37508524 G/C cg07936489 chr17:37558343 FBXL20 0.91 11.42 0.53 1.15e-25 Glomerular filtration rate (creatinine); CRC cis rs57221529 0.766 rs4957053 chr5:575927 T/C cg17948913 chr5:572064 NA 0.56 6.25 0.33 1.28e-9 Lung disease severity in cystic fibrosis; CRC cis rs10504229 0.683 rs7460059 chr8:58111561 C/T cg02290350 chr8:58132656 NA -0.6 -8.3 -0.42 2.8e-15 Developmental language disorder (linguistic errors); CRC cis rs7772486 0.846 rs9403767 chr6:146402386 G/T cg13319975 chr6:146136371 FBXO30 -0.41 -6.2 -0.32 1.68e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs12134245 0.776 rs625525 chr1:91997593 C/T cg07090678 chr1:91966139 CDC7 0.36 5.85 0.31 1.18e-8 Breast cancer; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg27401989 chr12:53774447 SP1 0.39 6.02 0.31 4.53e-9 Liver disease severity in Alagille syndrome; CRC trans rs208520 0.507 rs3903670 chr6:66812183 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.19 -26.05 -0.82 5.89e-82 Exhaled nitric oxide output; CRC cis rs9916302 0.706 rs3744349 chr17:37414842 C/T cg00129232 chr17:37814104 STARD3 -0.55 -6.97 -0.36 1.75e-11 Glomerular filtration rate (creatinine); CRC cis rs2952156 0.684 rs11658786 chr17:37815899 G/A cg15445000 chr17:37608096 MED1 0.27 6.06 0.32 3.81e-9 Asthma; CRC cis rs12681287 0.547 rs7461366 chr8:87511685 C/T cg27223183 chr8:87520930 FAM82B -0.52 -7.41 -0.38 1.05e-12 Caudate activity during reward; CRC cis rs1950626 0.569 rs4143956 chr14:101434356 A/T cg02351406 chr14:101447389 SNORD114-20;SNORD114-21 0.75 12.07 0.55 5.21e-28 Pelvic organ prolapse (moderate/severe); CRC trans rs1265507 0.577 rs1807094 chr12:114869797 C/A cg11700868 chr17:38521232 GJD3 0.42 5.99 0.31 5.5e-9 Percent mammographic density; CRC cis rs6502050 0.765 rs6502075 chr17:80121813 G/A cg09264619 chr17:80180166 NA -0.35 -5.93 -0.31 7.47e-9 Life satisfaction; CRC cis rs12711979 0.528 rs1823860 chr2:3867013 A/G cg17052675 chr2:3827356 NA -0.37 -5.92 -0.31 7.94e-9 Itch intensity from mosquito bite adjusted by bite size; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg11889002 chr15:52030128 LYSMD2 0.39 6.09 0.32 3.16e-9 Liver disease severity in Alagille syndrome; CRC cis rs921968 0.540 rs6746040 chr2:219588890 G/T cg02176678 chr2:219576539 TTLL4 -0.42 -6.72 -0.35 8.11e-11 Mean corpuscular hemoglobin concentration; CRC cis rs1865760 0.566 rs2858993 chr6:26087856 T/A cg16482183 chr6:26056742 HIST1H1C 0.51 7.36 0.38 1.45e-12 Height; CRC trans rs2303319 0.504 rs62187570 chr2:162373899 C/G cg18122310 chr12:50236657 BCDIN3D -0.72 -6.07 -0.32 3.54e-9 Cognitive function; CRC cis rs10504229 1.000 rs73609764 chr8:58192971 G/A cg22535103 chr8:58192502 C8orf71 -0.82 -12.27 -0.56 9.63e-29 Developmental language disorder (linguistic errors); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg05958510 chr12:89746351 DUSP6 0.42 6.12 0.32 2.72e-9 Intelligence (multi-trait analysis); CRC cis rs477692 1.000 rs569235 chr10:131411620 T/C cg05714579 chr10:131428358 MGMT 0.53 7.88 0.4 4.97e-14 Response to temozolomide; CRC cis rs3785574 0.962 rs4480868 chr17:61788859 C/T cg11494091 chr17:61959527 GH2 0.4 6.31 0.33 8.88e-10 Height; CRC cis rs9287719 0.967 rs6759100 chr2:10746710 A/G cg00105475 chr2:10696890 NA 0.45 7.15 0.37 5.48e-12 Prostate cancer; CRC cis rs875971 0.508 rs10253883 chr7:66061138 T/C cg18876405 chr7:65276391 NA -0.59 -10.62 -0.51 7.43e-23 Aortic root size; CRC cis rs826838 0.967 rs1352122 chr12:39130885 G/A cg26384229 chr12:38710491 ALG10B -0.64 -9.67 -0.47 1.21e-19 Heart rate; CRC cis rs9901225 1 rs9901225 chr17:40755811 C/T cg07694864 chr17:40700509 NA -0.42 -7.43 -0.38 9.42e-13 Colorectal or endometrial cancer; CRC cis rs959260 0.541 rs61417295 chr17:73356848 T/C cg14668889 chr17:73230827 NUP85 0.49 5.68 0.3 2.93e-8 Systemic lupus erythematosus; CRC cis rs7914558 0.966 rs56946876 chr10:104653545 T/C cg04362960 chr10:104952993 NT5C2 0.59 8.93 0.44 3.13e-17 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs798554 0.759 rs2644309 chr7:2889034 T/C cg04166393 chr7:2884313 GNA12 0.57 7.4 0.38 1.15e-12 Height; CRC cis rs6456156 0.716 rs6905911 chr6:167521624 C/T cg07513332 chr6:167530253 CCR6 0.37 6.01 0.31 4.81e-9 Primary biliary cholangitis; CRC cis rs9859260 0.710 rs366268 chr3:195782177 A/G cg12923728 chr3:195709715 SDHAP1 0.48 6.54 0.34 2.35e-10 Mean corpuscular volume; CRC cis rs4974559 0.947 rs28437782 chr4:1355062 A/G cg02980000 chr4:1222292 CTBP1 0.74 8.0 0.4 2.19e-14 Systolic blood pressure; CRC cis rs875971 0.867 rs1002053 chr7:65798545 G/A cg18912574 chr7:65842487 NCRNA00174 -0.36 -6.23 -0.32 1.44e-9 Aortic root size; CRC cis rs9462027 0.628 rs7745097 chr6:34794434 T/C cg07306190 chr6:34760872 UHRF1BP1 -0.35 -6.13 -0.32 2.45e-9 Systemic lupus erythematosus; CRC cis rs8105895 0.935 rs1968446 chr19:22279047 A/C cg02657401 chr19:22469223 NA -0.35 -5.67 -0.3 3.06e-8 Body mass index (change over time); CRC cis rs5751901 1.000 rs5751901 chr22:24992266 C/T cg15363607 chr22:24998974 GGT1 0.43 6.81 0.35 4.58e-11 Protein quantitative trait loci; CRC cis rs62229266 0.839 rs11702763 chr21:37470704 A/G cg08632701 chr21:37451849 NA -0.42 -6.35 -0.33 6.98e-10 Mitral valve prolapse; CRC cis rs4594175 0.926 rs7160948 chr14:51612537 T/A cg23942311 chr14:51606299 NA 0.65 10.48 0.5 2.33e-22 Cancer; CRC cis rs2836950 0.501 rs11088470 chr21:40689162 A/G cg11644478 chr21:40555479 PSMG1 -0.44 -6.53 -0.34 2.56e-10 Menarche (age at onset); CRC cis rs10504073 0.626 rs9298106 chr8:50007508 T/G cg00325661 chr8:49890786 NA 0.43 7.85 0.4 5.82e-14 Blood metabolite ratios; CRC cis rs939574 0.512 rs2276638 chr2:220145286 C/T cg00496455 chr2:220118770 TUBA4A;TUBA4B 0.55 6.26 0.33 1.21e-9 Platelet distribution width; CRC trans rs7618501 0.633 rs11130234 chr3:50024758 G/T cg21665057 chr3:196295764 WDR53;FBXO45 0.61 9.54 0.47 3.33e-19 Intelligence (multi-trait analysis); CRC cis rs9660992 0.710 rs1172138 chr1:205246019 G/A cg21643547 chr1:205240462 TMCC2 -0.45 -7.23 -0.37 3.31e-12 Mean corpuscular volume;Mean platelet volume; CRC cis rs3733585 0.673 rs4459990 chr4:9954005 T/C cg00071950 chr4:10020882 SLC2A9 -0.55 -9.74 -0.47 7.09e-20 Cleft plate (environmental tobacco smoke interaction); CRC cis rs1448094 0.817 rs61929421 chr12:86342330 T/C cg25456477 chr12:86230367 RASSF9 0.33 5.69 0.3 2.8e-8 Major depressive disorder; CRC cis rs5769765 0.862 rs9616392 chr22:50314705 G/A cg04121214 chr22:50244548 NA 0.41 5.91 0.31 8.44e-9 Schizophrenia; CRC cis rs1799949 0.965 rs4793204 chr17:41279298 A/G cg25072359 chr17:41440525 NA 0.46 6.93 0.36 2.19e-11 Menopause (age at onset); CRC cis rs8058578 0.945 rs8058961 chr16:30809063 G/A cg00531865 chr16:30841666 NA -0.46 -6.09 -0.32 3.22e-9 Multiple myeloma; CRC cis rs9733 0.596 rs72702573 chr1:150689050 C/T cg10589385 chr1:150898437 SETDB1 0.28 5.96 0.31 6.66e-9 Tonsillectomy; CRC cis rs2404602 0.647 rs35940181 chr15:77180019 G/A cg03037974 chr15:76606532 NA -0.54 -7.99 -0.4 2.22e-14 Blood metabolite levels; CRC cis rs17685 0.796 rs3757594 chr7:75678644 G/A cg16489192 chr7:75678113 MDH2;STYXL1 0.36 5.74 0.3 2.21e-8 Coffee consumption;Coffee consumption (cups per day); CRC cis rs769267 0.930 rs4808955 chr19:19552413 T/C cg02546618 chr19:19431379 KIAA0892;SF4 0.44 5.86 0.31 1.13e-8 Tonsillectomy; CRC cis rs6586163 0.872 rs7910825 chr10:90743341 G/A cg13456138 chr10:90753195 FAS -0.44 -6.58 -0.34 1.84e-10 Chronic lymphocytic leukemia; CRC cis rs78456975 1.000 rs72776252 chr2:1525599 G/A cg12573674 chr2:1569213 NA -0.74 -7.3 -0.37 2.21e-12 Placebo response in major depressive disorder (% change in symptom score); CRC cis rs7772486 0.686 rs9386131 chr6:146121608 G/A cg23711669 chr6:146136114 FBXO30 0.69 11.62 0.54 2.27e-26 Lobe attachment (rater-scored or self-reported); CRC cis rs2282802 0.635 rs269767 chr5:139536922 A/G cg26211634 chr5:139558579 C5orf32 0.4 6.97 0.36 1.74e-11 Intelligence (multi-trait analysis); CRC cis rs7618915 0.533 rs35107891 chr3:52613656 G/C cg18099408 chr3:52552593 STAB1 -0.45 -7.39 -0.38 1.22e-12 Bipolar disorder; CRC cis rs10927875 0.541 rs1763599 chr1:16342602 C/T cg22431228 chr1:16359049 CLCNKA -0.38 -6.91 -0.36 2.52e-11 Dilated cardiomyopathy; CRC cis rs501120 0.568 rs471451 chr10:44754785 G/C cg09554077 chr10:44749378 NA 0.68 6.53 0.34 2.44e-10 Coronary artery disease;Coronary heart disease; CRC cis rs11758351 1.000 rs16891397 chr6:26200256 C/T cg22723502 chr6:26240528 HIST1H4F -0.38 -5.86 -0.31 1.14e-8 Gout;Renal underexcretion gout; CRC cis rs10493773 0.775 rs12739713 chr1:86150378 C/T cg17807903 chr1:86174739 ZNHIT6 -0.48 -10.29 -0.49 9.93e-22 Urate levels in overweight individuals; CRC cis rs1348850 0.519 rs1527407 chr2:178525630 T/G cg22681709 chr2:178499509 PDE11A -0.41 -7.52 -0.38 5.1e-13 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs2841277 0.708 rs28454709 chr14:105405942 G/A cg14403583 chr14:105418241 AHNAK2 -0.34 -6.07 -0.32 3.47e-9 Rheumatoid arthritis; CRC trans rs1814175 0.538 rs1684260 chr11:49224231 G/A cg15704280 chr7:45808275 SEPT13 0.84 14.18 0.62 5.99e-36 Height; CRC cis rs801193 1.000 rs7788576 chr7:66148302 G/A cg11764359 chr7:65958608 NA -0.54 -8.3 -0.42 2.67e-15 Aortic root size; CRC cis rs2408955 0.521 rs7301003 chr12:48550227 A/G cg00601486 chr12:48723148 H1FNT 0.35 6.73 0.35 7.35e-11 Glycated hemoglobin levels; CRC trans rs2303319 0.504 rs56026147 chr2:162614089 T/C cg13490827 chr1:46269305 MAST2 -0.69 -6.0 -0.31 5.24e-9 Cognitive function; CRC trans rs10982213 0.830 rs2274163 chr9:117188714 C/T cg09601704 chr17:8027427 HES7 0.38 6.23 0.32 1.39e-9 Interleukin-6 levels; CRC cis rs9311474 0.841 rs352139 chr3:52258372 T/C cg15147215 chr3:52552868 STAB1 -0.51 -8.38 -0.42 1.59e-15 Electroencephalogram traits; CRC cis rs2281845 0.826 rs4915215 chr1:201077212 C/T cg01987224 chr1:201084466 NA -0.54 -10.39 -0.5 4.62e-22 Permanent tooth development; CRC cis rs12477438 0.798 rs4850891 chr2:99574642 A/G cg26064155 chr2:99771622 LIPT1;TSGA10 -0.75 -10.54 -0.5 1.39e-22 Chronic sinus infection; CRC cis rs9914988 0.943 rs9898892 chr17:27150750 T/C cg16670446 chr17:27188758 MIR451;MIR144 0.53 8.4 0.42 1.32e-15 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs375066 0.901 rs1978723 chr19:44383800 C/T cg12072164 chr19:44306565 LYPD5 -0.37 -5.77 -0.3 1.82e-8 Breast cancer; CRC cis rs6586163 0.509 rs2031610 chr10:90754487 T/C cg03111039 chr10:90751583 FAS;ACTA2 0.82 12.43 0.57 2.36e-29 Chronic lymphocytic leukemia; CRC cis rs34172651 0.917 rs12923476 chr16:24798079 G/A cg00339695 chr16:24857497 SLC5A11 0.28 6.19 0.32 1.79e-9 Intelligence (multi-trait analysis); CRC cis rs9814567 1.000 rs9985341 chr3:134232840 C/G cg06109529 chr3:134205091 CEP63;ANAPC13 -0.52 -5.86 -0.31 1.13e-8 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs3540 1.000 rs7173724 chr15:91036855 A/G cg04176472 chr15:90893244 GABARAPL3 0.32 5.64 0.3 3.65e-8 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; CRC cis rs294883 0.767 rs9346785 chr6:159704151 T/C cg14500486 chr6:159655392 FNDC1 -0.35 -5.75 -0.3 2.09e-8 Coronary artery disease; CRC cis rs12760731 0.622 rs71628291 chr1:178573743 G/A cg00404053 chr1:178313656 RASAL2 0.65 6.95 0.36 1.96e-11 Obesity-related traits; CRC cis rs13256369 1.000 rs13256369 chr8:8577379 T/C cg17143192 chr8:8559678 CLDN23 0.47 6.16 0.32 2.09e-9 Obesity-related traits; CRC cis rs4722166 0.532 rs4719712 chr7:22755807 C/T cg05472934 chr7:22766657 IL6 0.67 10.47 0.5 2.42e-22 Lung cancer; CRC cis rs6502050 0.835 rs9902485 chr17:80093701 C/T cg02741985 chr17:80059408 CCDC57 0.43 7.11 0.36 7.42e-12 Life satisfaction; CRC cis rs9487051 0.872 rs6924776 chr6:109612276 A/G cg12927641 chr6:109611667 NA -0.38 -6.95 -0.36 1.91e-11 Reticulocyte fraction of red cells; CRC cis rs3198697 1.000 rs3198697 chr16:15129940 C/T cg27102117 chr16:15229624 NA 0.37 5.89 0.31 9.3e-9 Triglycerides; CRC cis rs7487075 0.780 rs1873793 chr12:46761324 A/G cg22049899 chr12:47219821 SLC38A4 -0.35 -7.2 -0.37 4.16e-12 Itch intensity from mosquito bite; CRC cis rs9311676 0.632 rs11130637 chr3:58405573 C/G cg06643156 chr3:58380774 PXK 0.42 6.38 0.33 5.84e-10 Systemic lupus erythematosus; CRC cis rs61864810 1 rs61864810 chr12:46682009 G/A cg22049899 chr12:47219821 SLC38A4 0.3 5.89 0.31 9.31e-9 Itch intensity from mosquito bite; CRC cis rs3091242 0.867 rs602052 chr1:25722206 T/C cg27572855 chr1:25598939 RHD 0.35 6.26 0.33 1.18e-9 Erythrocyte sedimentation rate; CRC cis rs2243480 1.000 rs937108 chr7:65428452 G/A cg18252515 chr7:66147081 NA -1.07 -12.6 -0.57 5.61e-30 Diabetic kidney disease; CRC cis rs13118159 0.509 rs4974556 chr4:1358141 G/C cg20887711 chr4:1340912 KIAA1530 0.75 10.96 0.52 5e-24 Longevity; CRC cis rs17376456 0.877 rs10059230 chr5:93450347 A/G cg21475434 chr5:93447410 FAM172A 0.71 7.68 0.39 1.82e-13 Diabetic retinopathy; CRC cis rs6952808 0.929 rs11768206 chr7:1932151 T/G cg02951883 chr7:2050386 MAD1L1 -0.71 -11.4 -0.53 1.32e-25 Bipolar disorder and schizophrenia; CRC trans rs11098499 0.863 rs3736115 chr4:120488703 A/G cg25214090 chr10:38739885 LOC399744 -0.64 -9.93 -0.48 1.67e-20 Corneal astigmatism; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg00992913 chr1:156698515 C1orf66;ISG20L2 0.45 6.22 0.32 1.51e-9 Anxiety disorder; CRC cis rs2230307 0.536 rs12733952 chr1:100611571 A/G cg24955406 chr1:100503596 HIAT1 0.48 5.77 0.3 1.86e-8 Carotid intima media thickness; CRC cis rs12928939 0.517 rs17358402 chr16:71967927 C/T cg03805757 chr16:71968109 PKD1L3 -0.59 -7.75 -0.39 1.19e-13 Post bronchodilator FEV1; CRC cis rs12477438 1.000 rs17760953 chr2:99859863 G/A cg26064155 chr2:99771622 LIPT1;TSGA10 -0.72 -8.96 -0.44 2.47e-17 Chronic sinus infection; CRC cis rs9311474 0.597 rs6778735 chr3:52565100 T/C cg15147215 chr3:52552868 STAB1 -0.79 -16.41 -0.67 1.22e-44 Electroencephalogram traits; CRC cis rs10871290 0.881 rs3863439 chr16:74470644 T/C cg01733217 chr16:74700730 RFWD3 -0.72 -11.56 -0.54 3.6e-26 Breast cancer; CRC cis rs1008375 0.966 rs4235389 chr4:17696280 A/G cg16339924 chr4:17578868 LAP3 0.45 6.08 0.32 3.42e-9 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs3015497 0.789 rs2356457 chr14:51116863 C/T cg09863266 chr14:51125203 SAV1 -0.32 -5.96 -0.31 6.59e-9 Mean platelet volume; CRC cis rs477895 0.653 rs11603212 chr11:63927810 C/T cg04317338 chr11:64019027 PLCB3 -0.56 -6.73 -0.35 7.73e-11 Mean platelet volume; CRC cis rs72799341 1.000 rs72799341 chr16:30936743 G/A cg00531865 chr16:30841666 NA -0.51 -5.84 -0.31 1.28e-8 Diastolic blood pressure; CRC cis rs28386778 0.734 rs12946669 chr17:62006007 A/G cg11494091 chr17:61959527 GH2 0.65 11.78 0.54 5.9e-27 Prudent dietary pattern; CRC cis rs875971 0.755 rs10228885 chr7:65780529 C/G cg12463550 chr7:65579703 CRCP -0.5 -6.81 -0.35 4.65e-11 Aortic root size; CRC cis rs853679 0.607 rs201002 chr6:27808192 A/G cg26958806 chr6:27640298 NA 0.63 5.62 0.3 4.08e-8 Depression; CRC cis rs4363385 0.791 rs10788855 chr1:153002359 A/T cg25856811 chr1:152973957 SPRR3 -0.25 -6.79 -0.35 5.23e-11 Inflammatory skin disease; CRC cis rs7680126 0.596 rs74778870 chr4:10298583 A/G cg11266682 chr4:10021025 SLC2A9 -0.38 -5.87 -0.31 1.04e-8 Urate levels in lean individuals;Urate levels in overweight individuals;Urate levels in obese individuals; CRC cis rs6582630 0.537 rs35336822 chr12:38346251 T/C cg13010199 chr12:38710504 ALG10B 0.47 6.4 0.33 5.45e-10 Drug-induced liver injury (flucloxacillin); CRC cis rs2302729 0.545 rs3794291 chr12:2769665 C/T cg19945202 chr12:2788847 CACNA1C -0.5 -7.98 -0.4 2.43e-14 Sleep quality; CRC cis rs4588572 0.606 rs6859161 chr5:77742776 A/G cg11446398 chr5:77624930 NA 0.42 6.01 0.31 5.01e-9 Triglycerides; CRC cis rs554111 0.891 rs671905 chr1:21047092 A/T cg08890418 chr1:21044141 KIF17 0.31 5.65 0.3 3.46e-8 Facial morphology (factor 17, height of vermillion upper lip); CRC cis rs7208859 0.623 rs11650271 chr17:29213943 C/T cg14008862 chr17:28927542 LRRC37B2 0.54 5.68 0.3 2.91e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs4737010 0.644 rs522407 chr8:41610969 G/A cg17182837 chr8:41585554 ANK1 0.53 7.55 0.38 4.41e-13 Lymphocyte counts;High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Reticulocyte count;Reticulocyte fraction of red cells;Mean corpuscular volume;Immature fraction of reticulocytes;Mean corpuscular hemoglobin concentration; CRC cis rs9534288 0.619 rs2146881 chr13:46679598 T/C cg15192986 chr13:46630673 CPB2 -0.65 -8.83 -0.44 6.25e-17 Blood protein levels; CRC cis rs2404602 0.669 rs12916324 chr15:77179603 G/A cg03037974 chr15:76606532 NA 0.68 11.55 0.54 4.06e-26 Blood metabolite levels; CRC cis rs10540 0.908 rs1044707 chr11:491334 G/T cg19913688 chr11:428466 ANO9 0.66 6.98 0.36 1.67e-11 Body mass index; CRC cis rs56307353 0.753 rs62129495 chr19:1962789 T/C cg05502645 chr19:1971281 CSNK1G2 0.47 7.28 0.37 2.51e-12 Coronary artery disease; CRC cis rs35883536 0.626 rs7536054 chr1:101047849 A/G cg06223162 chr1:101003688 GPR88 -0.34 -6.13 -0.32 2.45e-9 Monocyte count; CRC cis rs12477438 0.520 rs6741772 chr2:99738961 A/G cg14399236 chr2:99771627 LIPT1;TSGA10 0.82 14.31 0.62 1.84e-36 Chronic sinus infection; CRC cis rs9916302 0.706 rs57933226 chr17:37412829 C/T cg07936489 chr17:37558343 FBXL20 -0.87 -11.28 -0.53 3.61e-25 Glomerular filtration rate (creatinine); CRC trans rs875971 0.660 rs2191268 chr7:66110224 C/T cg03276813 chr2:182757157 SSFA2 -0.42 -6.34 -0.33 7.69e-10 Aortic root size; CRC cis rs11971779 0.680 rs6962366 chr7:139043867 G/A cg07862535 chr7:139043722 LUC7L2 0.57 7.35 0.38 1.61e-12 Diisocyanate-induced asthma; CRC cis rs9303401 0.659 rs36109237 chr17:56653834 A/G cg02118635 chr17:56770003 RAD51C;TEX14 0.78 9.77 0.47 5.98e-20 Cognitive test performance; CRC cis rs11123170 0.503 rs28679654 chr2:113967617 C/T cg11763394 chr2:113992921 PAX8;LOC440839;LOC654433 0.5 5.98 0.31 5.73e-9 Renal function-related traits (BUN); CRC cis rs6933660 0.646 rs9383899 chr6:151781022 G/C cg14262678 chr6:151773367 RMND1;C6orf211 0.51 8.2 0.41 5.27e-15 Menarche (age at onset); CRC cis rs2286885 1.000 rs7851961 chr9:129249140 G/A cg15282417 chr9:129245246 FAM125B 0.46 8.59 0.43 3.56e-16 Intraocular pressure; CRC cis rs720844 0.684 rs34881950 chr2:149303493 C/A cg09247360 chr2:149335327 NA -0.57 -5.95 -0.31 6.69e-9 Peripheral arterial disease (traffic-related air pollution interaction); CRC trans rs10858396 0.957 rs7029858 chr9:138273821 C/T cg26979339 chr12:107168153 RIC8B 0.49 6.45 0.34 3.93e-10 Attention deficit hyperactivity disorder; CRC trans rs6550704 0.687 rs9865314 chr3:22634337 A/G cg24028350 chr3:33482811 UBP1 -0.41 -6.07 -0.32 3.49e-9 Daytime sleep phenotypes; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg10143842 chr3:88198517 C3orf38 0.47 6.4 0.33 5.4e-10 Anxiety disorder; CRC cis rs1552244 0.816 rs56271597 chr3:10042790 C/T cg00166722 chr3:10149974 C3orf24 0.63 8.28 0.42 3.08e-15 Alzheimer's disease; CRC cis rs2346177 0.875 rs2346178 chr2:46647061 C/G cg26688816 chr2:46740690 ATP6V1E2 -0.5 -8.01 -0.4 2.03e-14 HDL cholesterol; CRC cis rs854765 0.647 rs854769 chr17:18019011 A/G cg09796270 chr17:17721594 SREBF1 -0.41 -6.6 -0.34 1.66e-10 Total body bone mineral density; CRC cis rs7618915 0.571 rs6778844 chr3:52596398 C/T cg10802521 chr3:52805072 NEK4 0.58 8.69 0.43 1.7e-16 Bipolar disorder; CRC cis rs453301 0.507 rs2929306 chr8:9084909 C/T cg08975724 chr8:8085496 FLJ10661 -0.39 -6.05 -0.32 3.94e-9 Joint mobility (Beighton score); CRC cis rs172166 0.694 rs2791332 chr6:28108788 C/T cg15786705 chr6:28176104 NA 0.62 8.81 0.44 7.1e-17 Cardiac Troponin-T levels; CRC cis rs2019137 0.560 rs7421852 chr2:113990261 G/A cg11763394 chr2:113992921 PAX8;LOC440839;LOC654433 0.64 9.64 0.47 1.61e-19 Lymphocyte counts; CRC trans rs2797160 1.000 rs77678056 chr6:126019738 A/G cg05039488 chr6:79577232 IRAK1BP1 0.51 7.54 0.38 4.75e-13 Endometrial cancer; CRC cis rs9381040 0.655 rs9394756 chr6:41016183 A/G cg25110423 chr6:41068646 NFYA;LOC221442 -0.39 -5.98 -0.31 5.79e-9 Alzheimer's disease (late onset); CRC cis rs35306767 0.903 rs1341741 chr10:888073 A/G cg20503657 chr10:835505 NA 0.88 11.07 0.52 2.05e-24 Eosinophil percentage of granulocytes; CRC cis rs28386778 0.897 rs7222189 chr17:61836372 T/C cg23090583 chr17:61904693 PSMC5;FTSJ3 1.04 20.65 0.75 2.49e-61 Prudent dietary pattern; CRC cis rs17253792 0.915 rs17832389 chr14:56185836 A/G cg01858014 chr14:56050164 KTN1 -0.73 -5.65 -0.3 3.4e-8 Putamen volume; CRC cis rs9649213 0.574 rs34830366 chr7:97899535 G/T cg24562669 chr7:97807699 LMTK2 0.47 7.84 0.4 6.48e-14 Prostate cancer (SNP x SNP interaction); CRC cis rs11628318 0.713 rs4900543 chr14:103029024 T/C cg12046867 chr14:103022105 NA -0.82 -11.52 -0.54 4.93e-26 Platelet count; CRC cis rs6952808 0.723 rs11765550 chr7:2027324 G/A cg00106254 chr7:1943704 MAD1L1 -0.57 -8.37 -0.42 1.73e-15 Bipolar disorder and schizophrenia; CRC cis rs9300255 0.739 rs1879380 chr12:123739111 G/A cg00376283 chr12:123451042 ABCB9 -0.55 -6.05 -0.32 4.01e-9 Neutrophil percentage of white cells; CRC cis rs12898370 0.561 rs11630770 chr15:77469643 A/G cg05673287 chr15:77411982 SGK269 0.53 5.8 0.3 1.57e-8 Risky sexual behaviors (alcohol dependence interaction); CRC cis rs2252521 0.583 rs317706 chr7:29097265 C/T cg11728747 chr7:29037910 CPVL -0.49 -6.95 -0.36 2e-11 Cognitive performance; CRC cis rs6502050 0.799 rs4789667 chr17:80162143 C/T cg02741985 chr17:80059408 CCDC57 0.45 7.44 0.38 9.06e-13 Life satisfaction; CRC cis rs9372498 0.536 rs9489428 chr6:118852935 T/C cg22561889 chr6:118971681 C6orf204 0.51 6.65 0.34 1.26e-10 Diastolic blood pressure; CRC cis rs1008375 0.932 rs4698650 chr4:17692878 G/C cg16339924 chr4:17578868 LAP3 0.47 6.31 0.33 8.96e-10 Parasitemia in Tripanosoma cruzi seropositivity; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg25365794 chr17:8022404 ALOXE3 0.52 7.54 0.38 4.56e-13 Response to antipsychotic treatment; CRC cis rs56399783 0.803 rs7811164 chr7:2822416 G/A cg19731401 chr7:2775893 GNA12 0.53 6.22 0.32 1.53e-9 Childhood ear infection; CRC cis rs7082209 1.000 rs4491167 chr10:44810820 T/A cg09554077 chr10:44749378 NA 0.43 5.62 0.3 4.04e-8 Resistance to Mycobacterium tuberculosis in HIV-positive individuals measured by a negative tuberculin skin test (continuous); CRC cis rs2952156 0.883 rs12150603 chr17:37834715 G/A cg07936489 chr17:37558343 FBXL20 -0.45 -6.61 -0.34 1.54e-10 Asthma; CRC cis rs1448094 0.802 rs7487591 chr12:86434112 T/C cg02569458 chr12:86230093 RASSF9 0.39 6.56 0.34 2.15e-10 Major depressive disorder; CRC cis rs7089973 0.934 rs12771956 chr10:116576228 C/G cg23260525 chr10:116636907 FAM160B1 0.31 5.97 0.31 6.21e-9 Bipolar disorder or attention deficit hyperactivity disorder; CRC trans rs9956878 0.555 rs8085188 chr18:73544676 A/G cg04175895 chr11:64851783 CDCA5;ZFPL1 -0.4 -6.11 -0.32 2.85e-9 Obesity-related traits; CRC cis rs9291683 0.525 rs12506455 chr4:10031569 T/A cg00071950 chr4:10020882 SLC2A9 0.67 12.54 0.57 9.24e-30 Bone mineral density; CRC trans rs1005277 0.579 rs176838 chr10:38371899 A/T cg27523141 chr10:43048294 ZNF37B -0.49 -7.2 -0.37 4.01e-12 Extrinsic epigenetic age acceleration; CRC cis rs34779708 0.643 rs4275563 chr10:35545286 G/A cg03585969 chr10:35415529 CREM 0.55 7.07 0.36 9.2e-12 Inflammatory bowel disease;Crohn's disease; CRC cis rs2153535 0.580 rs6597335 chr6:8527714 T/C cg07606381 chr6:8435919 SLC35B3 0.67 10.85 0.51 1.15e-23 Motion sickness; CRC cis rs59698941 0.550 rs11748737 chr5:132201070 C/T cg14825688 chr5:132208181 LEAP2 -0.41 -6.53 -0.34 2.49e-10 Apolipoprotein A-IV levels; CRC cis rs1552244 0.882 rs35056669 chr3:10014171 C/T cg08888203 chr3:10149979 C3orf24 0.62 8.32 0.42 2.36e-15 Alzheimer's disease; CRC cis rs9322193 0.884 rs11155679 chr6:150080017 T/C cg07701084 chr6:150067640 NUP43 0.54 7.44 0.38 8.71e-13 Lung cancer; CRC cis rs3026101 0.671 rs1806240 chr17:5298320 C/T cg25236894 chr17:5323110 RPAIN;NUP88 0.42 6.84 0.35 3.98e-11 Body mass index; CRC cis rs11123170 0.543 rs4849180 chr2:113985186 C/G cg11763394 chr2:113992921 PAX8;LOC440839;LOC654433 0.5 5.88 0.31 9.98e-9 Renal function-related traits (BUN); CRC cis rs1799949 1.000 rs11654731 chr17:41326940 G/A cg05368731 chr17:41323189 NBR1 0.65 9.54 0.47 3.3e-19 Menopause (age at onset); CRC cis rs6502050 0.835 rs9902485 chr17:80093701 C/T cg19223190 chr17:80058835 NA 0.4 6.5 0.34 3.06e-10 Life satisfaction; CRC cis rs9303401 0.580 rs12946396 chr17:57164195 T/A cg02118635 chr17:56770003 RAD51C;TEX14 0.76 9.09 0.45 9.67e-18 Cognitive test performance; CRC cis rs2070488 0.699 rs13078966 chr3:38517914 T/G cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.82 14.16 0.62 7.28e-36 Electrocardiographic conduction measures; CRC cis rs7666738 0.888 rs13110683 chr4:98983368 G/C cg03676636 chr4:99064102 C4orf37 0.24 6.67 0.35 1.08e-10 Colonoscopy-negative controls vs population controls; CRC cis rs10065203 0.527 rs181927 chr5:14351946 G/T cg26689441 chr5:14406021 TRIO -0.36 -6.04 -0.32 4.14e-9 Paclitaxel-induced neuropathy; CRC cis rs6460942 0.908 rs112897715 chr7:12241541 T/C cg06484146 chr7:12443880 VWDE -0.59 -6.22 -0.32 1.47e-9 Coronary artery disease; CRC trans rs6703335 0.870 rs10803142 chr1:243598234 A/G cg14966992 chr3:127842884 RUVBL1 0.45 6.2 0.32 1.7e-9 Schizophrenia;Schizophrenia, schizoaffective disorder or bipolar disorder; CRC cis rs2408955 0.521 rs7301003 chr12:48550227 A/G cg24011408 chr12:48396354 COL2A1 0.45 6.55 0.34 2.21e-10 Glycated hemoglobin levels; CRC trans rs60843830 1.000 rs62114548 chr2:274672 C/G cg11347411 chr7:150020925 ACTR3C;LRRC61 0.61 9.39 0.46 1.04e-18 Spherical equivalent (joint analysis main effects and education interaction); CRC cis rs875971 0.830 rs6950137 chr7:65976610 G/A cg11764359 chr7:65958608 NA 0.61 9.51 0.46 4.28e-19 Aortic root size; CRC cis rs6598955 0.671 rs55791848 chr1:26582711 G/A cg04990556 chr1:26633338 UBXN11 0.56 6.02 0.32 4.53e-9 Obesity-related traits; CRC cis rs736408 0.609 rs13082960 chr3:52785168 A/C cg08222913 chr3:52553049 STAB1 -0.34 -6.08 -0.32 3.35e-9 Bipolar disorder; CRC cis rs7666738 0.830 rs28465658 chr4:99035866 T/C cg05340658 chr4:99064831 C4orf37 0.61 9.43 0.46 7.65e-19 Colonoscopy-negative controls vs population controls; CRC cis rs10504229 0.683 rs56208052 chr8:58130207 A/T cg04204079 chr8:58130323 NA -0.45 -5.78 -0.3 1.71e-8 Developmental language disorder (linguistic errors); CRC cis rs7615952 0.512 rs4646765 chr3:125820707 G/A cg05084668 chr3:125655381 ALG1L -0.45 -6.4 -0.33 5.22e-10 Blood pressure (smoking interaction); CRC trans rs853679 0.546 rs200996 chr6:27811828 G/A cg06606381 chr12:133084897 FBRSL1 -0.73 -6.45 -0.34 3.98e-10 Depression; CRC cis rs10751667 0.961 rs6597954 chr11:987677 G/A ch.11.42038R chr11:967971 AP2A2 0.7 11.76 0.54 7.07e-27 Alzheimer's disease (late onset); CRC cis rs875971 0.895 rs4718349 chr7:65909011 C/G cg12463550 chr7:65579703 CRCP 0.48 6.78 0.35 5.54e-11 Aortic root size; CRC trans rs2228479 0.850 rs17232910 chr16:89839766 G/C cg24644049 chr4:85504048 CDS1 0.9 7.57 0.39 3.72e-13 Skin colour saturation; CRC cis rs1799949 1.000 rs4793189 chr17:41190715 G/A cg23758822 chr17:41437982 NA 0.8 13.18 0.59 3.91e-32 Menopause (age at onset); CRC cis rs4363385 0.747 rs1933383 chr1:152963468 C/T cg25856811 chr1:152973957 SPRR3 -0.27 -7.49 -0.38 6.31e-13 Inflammatory skin disease; CRC cis rs34172651 0.876 rs964782 chr16:24811740 T/C cg00339695 chr16:24857497 SLC5A11 0.29 6.41 0.33 4.92e-10 Intelligence (multi-trait analysis); CRC cis rs739401 0.566 rs7931504 chr11:3026712 C/T cg08508325 chr11:3079039 CARS -0.5 -9.06 -0.45 1.15e-17 Longevity; CRC trans rs7395662 0.853 rs10769356 chr11:48444654 T/G cg21153622 chr11:89784906 NA -0.46 -7.26 -0.37 2.75e-12 HDL cholesterol; CRC cis rs2882667 0.858 rs11959851 chr5:138421405 C/G cg04439458 chr5:138467593 SIL1 -0.34 -5.84 -0.31 1.27e-8 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs950776 0.518 rs28438420 chr15:78836288 A/T cg06917634 chr15:78832804 PSMA4 -0.62 -9.73 -0.47 7.9e-20 Sudden cardiac arrest; CRC cis rs477895 0.838 rs1058735 chr11:64000410 C/G cg18375707 chr11:64034959 PLCB3 0.46 6.46 0.34 3.81e-10 Mean platelet volume; CRC cis rs57920188 0.640 rs4478781 chr1:4086827 C/T cg10510935 chr1:4059661 NA 0.39 5.88 0.31 9.86e-9 Interleukin-17 levels; CRC trans rs2303319 0.504 rs12467613 chr2:162603216 G/T cg27342122 chr8:133787442 PHF20L1 -0.72 -6.12 -0.32 2.68e-9 Cognitive function; CRC cis rs2976388 0.647 rs2585136 chr8:143812141 A/G cg05569086 chr8:143859399 LYNX1 0.39 6.58 0.34 1.81e-10 Urinary tract infection frequency; CRC cis rs875971 0.862 rs6460293 chr7:65810192 C/A cg00343986 chr7:65444356 GUSB -0.45 -6.24 -0.33 1.35e-9 Aortic root size; CRC cis rs3862260 0.509 rs1045827 chr1:120162442 C/T cg11530693 chr1:120165357 ZNF697 -0.6 -9.54 -0.47 3.45e-19 Systemic lupus erythematosus; CRC cis rs7552404 1.000 rs211723 chr1:76103030 C/T cg03433033 chr1:76189801 ACADM -0.76 -10.47 -0.5 2.5e-22 Blood metabolite levels;Acylcarnitine levels; CRC cis rs727505 0.721 rs67817822 chr7:124769572 A/G cg23710748 chr7:124431027 NA -0.68 -11.61 -0.54 2.41e-26 Lewy body disease; CRC cis rs6502050 0.731 rs9891378 chr17:80116035 T/C cg22110888 chr17:80059540 CCDC57 0.4 6.48 0.34 3.37e-10 Life satisfaction; CRC cis rs6545883 0.965 rs12713439 chr2:61752154 G/A cg15711740 chr2:61764176 XPO1 -0.51 -7.1 -0.36 7.78e-12 Tuberculosis; CRC cis rs72730918 0.590 rs12324531 chr15:51921358 T/C cg14296394 chr15:51910925 DMXL2 -0.47 -6.32 -0.33 8.69e-10 Intelligence (multi-trait analysis); CRC cis rs1448094 0.511 rs34885805 chr12:86155180 A/T cg00310523 chr12:86230176 RASSF9 0.41 6.62 0.34 1.5e-10 Major depressive disorder; CRC cis rs67478160 0.643 rs12434686 chr14:104316033 C/T cg01849466 chr14:104193079 ZFYVE21 0.47 8.09 0.41 1.14e-14 Schizophrenia; CRC cis rs1577917 0.958 rs10806337 chr6:86474249 G/A cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.61 -7.67 -0.39 1.95e-13 Response to antipsychotic treatment; CRC cis rs9443645 0.803 rs1547731 chr6:79776104 A/G cg11833968 chr6:79620685 NA -0.36 -6.16 -0.32 2.07e-9 Intelligence (multi-trait analysis); CRC cis rs2739330 0.828 rs4820572 chr22:24250355 T/C cg04234412 chr22:24373322 LOC391322 -0.72 -11.23 -0.53 5.26e-25 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs911555 0.723 rs7144010 chr14:103869869 G/A cg12935359 chr14:103987150 CKB 0.54 8.75 0.43 1.15e-16 Intelligence (multi-trait analysis); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg06632829 chr19:45394476 TOMM40 0.43 5.97 0.31 6.28e-9 Response to antipsychotic treatment; CRC cis rs12900413 0.687 rs13343254 chr15:90311283 G/A cg24249390 chr15:90295951 MESP1 -0.58 -9.3 -0.46 1.95e-18 Coronary artery aneurysm in Kawasaki disease; CRC trans rs2228479 1.000 rs117406136 chr16:89974605 C/T cg21302420 chr1:112162376 RAP1A 0.77 6.85 0.35 3.64e-11 Skin colour saturation; CRC cis rs7811142 1.000 rs6962151 chr7:100028484 T/C cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.62 8.34 0.42 2.01e-15 Platelet count; CRC trans rs7615952 0.558 rs7641353 chr3:125339879 T/C cg21747405 chr11:67723411 NA -0.57 -8.92 -0.44 3.38e-17 Blood pressure (smoking interaction); CRC cis rs11233250 0.502 rs1497104 chr11:82411635 C/T cg17391194 chr11:82401662 NA -0.38 -5.91 -0.31 8.35e-9 Glioblastoma;Glioma; CRC cis rs35306767 0.904 rs10904584 chr10:983747 A/T cg26597838 chr10:835615 NA 0.8 9.97 0.48 1.2e-20 Eosinophil percentage of granulocytes; CRC cis rs9611565 0.659 rs9611609 chr22:41945357 C/A cg06481639 chr22:41940642 POLR3H -0.51 -5.89 -0.31 9.36e-9 Vitiligo; CRC cis rs12477438 0.798 rs896886 chr2:99652713 C/T cg14399236 chr2:99771627 LIPT1;TSGA10 0.71 10.04 0.48 7.38e-21 Chronic sinus infection; CRC cis rs1552244 0.935 rs4441636 chr3:10083876 G/A cg00166722 chr3:10149974 C3orf24 0.71 9.41 0.46 8.98e-19 Alzheimer's disease; CRC cis rs7647973 0.516 rs12490393 chr3:49196132 C/T cg20833759 chr3:49053208 WDR6;DALRD3 0.39 6.41 0.33 5.07e-10 Menarche (age at onset); CRC cis rs28386778 0.669 rs12603821 chr17:62006432 G/A cg11494091 chr17:61959527 GH2 -0.65 -11.53 -0.54 4.59e-26 Prudent dietary pattern; CRC cis rs96067 0.711 rs272811 chr1:36634414 G/A cg25304816 chr1:36627734 MAP7D1 0.47 7.08 0.36 9.02e-12 Corneal structure; CRC trans rs9929218 0.551 rs2281850 chr16:68718750 C/T cg04657470 chr2:198365150 HSPE1;HSPD1 -1.23 -31.48 -0.87 2.93e-101 Colorectal cancer; CRC cis rs28386778 0.897 rs2584640 chr17:61863488 C/T cg25654072 chr17:61904446 PSMC5;FTSJ3 0.72 11.3 0.53 2.97e-25 Prudent dietary pattern; CRC trans rs7395662 0.504 rs2019666 chr11:48437729 C/T cg21153622 chr11:89784906 NA -0.5 -8.33 -0.42 2.15e-15 HDL cholesterol; CRC trans rs2832077 0.943 rs2832094 chr21:30165910 G/A cg14791747 chr16:20752902 THUMPD1 0.55 6.88 0.35 2.96e-11 Cognitive test performance; CRC cis rs7085104 0.514 rs284855 chr10:104574422 A/G cg11453585 chr10:104263688 ACTR1A;SUFU 0.4 5.86 0.31 1.14e-8 Immature fraction of reticulocytes;Schizophrenia; CRC cis rs1005277 0.579 rs2504143 chr10:38383706 C/T cg17219203 chr10:38645113 HSD17B7P2 -0.41 -5.81 -0.31 1.45e-8 Extrinsic epigenetic age acceleration; CRC cis rs1865760 0.532 rs1061482 chr6:26086699 G/T cg18357526 chr6:26021779 HIST1H4A 0.43 6.06 0.32 3.79e-9 Height; CRC cis rs73206853 0.841 rs9783428 chr12:111068096 C/T cg12870014 chr12:110450643 ANKRD13A 0.71 7.54 0.38 4.51e-13 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC cis rs1552244 0.882 rs56332224 chr3:10037321 G/A cg00166722 chr3:10149974 C3orf24 0.64 8.38 0.42 1.6e-15 Alzheimer's disease; CRC cis rs9902453 0.817 rs2729435 chr17:28121532 T/C cg26525008 chr17:28256777 EFCAB5;SSH2 -0.58 -8.75 -0.43 1.1e-16 Coffee consumption (cups per day); CRC cis rs477895 0.838 rs11607007 chr11:64007976 C/T cg18375707 chr11:64034959 PLCB3 0.46 6.29 0.33 9.86e-10 Mean platelet volume; CRC cis rs561341 1.000 rs113115092 chr17:30284164 G/A cg00745463 chr17:30367425 LRRC37B -0.9 -9.89 -0.48 2.27e-20 Hip circumference adjusted for BMI; CRC trans rs12599106 0.624 rs2173885 chr16:34992749 G/A cg11235426 chr6:292522 DUSP22 -0.66 -9.46 -0.46 6.16e-19 Menopause (age at onset); CRC cis rs4073582 0.595 rs1115508 chr11:65923149 A/G cg14036092 chr11:66035641 RAB1B 0.52 8.4 0.42 1.39e-15 Gout; CRC cis rs10493773 0.775 rs12564080 chr1:86196586 A/C cg00734567 chr1:86172782 ZNHIT6 -0.4 -5.66 -0.3 3.36e-8 Urate levels in overweight individuals; CRC cis rs877282 0.583 rs12358255 chr10:828626 C/T cg17470449 chr10:769945 NA 0.51 7.4 0.38 1.18e-12 Uric acid levels; CRC cis rs1577917 0.916 rs12198730 chr6:86555138 G/A cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.53 -6.69 -0.35 9.4e-11 Response to antipsychotic treatment; CRC cis rs10751667 0.857 rs6597952 chr11:991109 C/G ch.11.42038R chr11:967971 AP2A2 0.7 11.72 0.54 9.41e-27 Alzheimer's disease (late onset); CRC cis rs9900062 0.586 rs12600679 chr17:62687327 T/G cg02598441 chr17:62777298 LOC146880 -0.54 -7.08 -0.36 8.78e-12 QT interval; CRC cis rs990171 0.913 rs1403554 chr2:103083453 G/A cg03938978 chr2:103052716 IL18RAP 0.46 5.88 0.31 1e-8 Lymphocyte counts; CRC cis rs4423214 0.802 rs4402322 chr11:71184015 C/G cg05163923 chr11:71159392 DHCR7 -0.63 -7.61 -0.39 2.92e-13 Vitamin D levels; CRC cis rs875971 0.862 rs1167390 chr7:65575893 G/A cg11764359 chr7:65958608 NA -0.58 -9.08 -0.45 1.04e-17 Aortic root size; CRC cis rs3790844 0.955 rs3790848 chr1:200006111 C/A cg07208853 chr1:200005219 NR5A2 0.34 8.22 0.41 4.91e-15 Pancreatic cancer; CRC cis rs853679 0.546 rs200981 chr6:27833174 A/G cg08798685 chr6:27730294 NA -0.64 -6.17 -0.32 1.98e-9 Depression; CRC cis rs728616 0.558 rs2880599 chr10:82164435 A/G cg11900509 chr10:81946545 ANXA11 -0.56 -6.24 -0.33 1.32e-9 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs10504229 0.953 rs72652908 chr8:58191324 G/A cg02290350 chr8:58132656 NA -0.42 -5.96 -0.31 6.62e-9 Developmental language disorder (linguistic errors); CRC cis rs9733 0.596 rs34600506 chr1:150687808 C/G cg15448220 chr1:150897856 SETDB1 0.45 6.41 0.33 5.09e-10 Tonsillectomy; CRC cis rs1448094 0.512 rs2405632 chr12:86252456 A/G cg00310523 chr12:86230176 RASSF9 0.34 5.77 0.3 1.88e-8 Major depressive disorder; CRC cis rs1799949 0.965 rs33925201 chr17:41280682 A/G cg05368731 chr17:41323189 NBR1 0.69 10.51 0.5 1.83e-22 Menopause (age at onset); CRC cis rs2370759 1.000 rs77165999 chr10:32577131 T/C cg01819863 chr10:32635814 EPC1 1.08 13.14 0.59 5.59e-32 Sexual dysfunction (female); CRC cis rs801193 1.000 rs2420824 chr7:66131116 G/A cg00343986 chr7:65444356 GUSB -0.46 -6.82 -0.35 4.32e-11 Aortic root size; CRC cis rs7917772 0.582 rs10786698 chr10:104378750 G/A cg11453585 chr10:104263688 ACTR1A;SUFU 0.81 14.74 0.63 3.98e-38 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC cis rs992157 0.687 rs10206984 chr2:219066980 C/T cg00012203 chr2:219082015 ARPC2 0.62 10.52 0.5 1.68e-22 Colorectal cancer; CRC cis rs2806561 0.734 rs7548692 chr1:23354877 T/A cg12483005 chr1:23474871 LUZP1 0.45 6.44 0.33 4.31e-10 Height; CRC cis rs950169 0.920 rs11637666 chr15:84703874 A/G cg11189052 chr15:85197271 WDR73 0.61 8.41 0.42 1.25e-15 Schizophrenia; CRC cis rs6456156 0.586 rs6456154 chr6:167472256 C/T cg07741184 chr6:167504864 NA 0.39 6.85 0.35 3.66e-11 Primary biliary cholangitis; CRC trans rs660498 0.641 rs72810095 chr10:27732984 T/G cg13661793 chr10:32399026 NA -0.33 -5.99 -0.31 5.52e-9 Asthma (childhood onset); CRC trans rs10983614 1.000 rs7867776 chr9:120072627 A/G cg08005411 chr12:69753742 YEATS4 0.46 6.04 0.32 4.25e-9 Survival in pancreatic cancer; CRC cis rs875971 0.522 rs1617484 chr7:65463095 G/A cg05627663 chr7:65219948 SNORA22;CCT6P1 0.49 7.25 0.37 3.03e-12 Aortic root size; CRC cis rs17270561 0.609 rs9358883 chr6:25755515 A/G cg16482183 chr6:26056742 HIST1H1C 0.83 10.58 0.5 1e-22 Iron status biomarkers; CRC trans rs2727020 0.617 rs7102702 chr11:49401125 T/G cg11707556 chr5:10655725 ANKRD33B -0.38 -6.14 -0.32 2.41e-9 Coronary artery disease; CRC cis rs7937682 0.575 rs10789851 chr11:111750955 G/C cg19812747 chr11:111475976 SIK2 0.42 6.21 0.32 1.57e-9 Primary sclerosing cholangitis; CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg20769334 chr22:50913335 SBF1 0.38 6.21 0.32 1.63e-9 Obesity-related traits; CRC cis rs3204270 0.759 rs8066217 chr17:79672615 C/G cg09655341 chr17:79618100 PDE6G 0.55 6.5 0.34 2.95e-10 Dental caries; CRC cis rs2415984 0.579 rs10140977 chr14:46955156 T/A cg14871534 chr14:47121158 RPL10L -0.43 -6.2 -0.32 1.74e-9 Number of children ever born; CRC cis rs172166 0.515 rs2622320 chr6:28115336 T/A cg25164649 chr6:28176230 NA 0.47 6.88 0.35 2.98e-11 Cardiac Troponin-T levels; CRC cis rs7539542 0.536 rs12091234 chr1:202855508 C/T cg19681188 chr1:202830198 LOC148709 0.46 6.57 0.34 1.98e-10 Mean platelet volume; CRC cis rs2836974 0.932 rs6517527 chr21:40581751 G/A cg11890956 chr21:40555474 PSMG1 1.09 18.81 0.72 4.31e-54 Cognitive function; CRC cis rs921968 0.510 rs620887 chr2:219465594 C/A cg02176678 chr2:219576539 TTLL4 0.54 8.51 0.42 6.18e-16 Mean corpuscular hemoglobin concentration; CRC cis rs17376456 0.597 rs1031423 chr5:93276883 A/G cg21475434 chr5:93447410 FAM172A -0.45 -6.31 -0.33 9.06e-10 Diabetic retinopathy; CRC trans rs61931739 0.517 rs11053224 chr12:34484919 G/A cg26384229 chr12:38710491 ALG10B 0.65 8.84 0.44 5.72e-17 Morning vs. evening chronotype; CRC cis rs17253792 0.822 rs10136155 chr14:56049129 G/A cg24579896 chr14:56047964 C14orf33;KTN1 0.7 5.96 0.31 6.51e-9 Putamen volume; CRC cis rs2836974 0.932 rs13048178 chr21:40561012 G/T cg11890956 chr21:40555474 PSMG1 1.09 18.38 0.71 2.07e-52 Cognitive function; CRC cis rs763121 0.853 rs5750664 chr22:39072769 C/T cg06022373 chr22:39101656 GTPBP1 0.8 12.62 0.57 4.84e-30 Menopause (age at onset); CRC cis rs6860806 0.603 rs112300250 chr5:131583292 G/A cg22638593 chr5:131593259 PDLIM4 0.4 7.41 0.38 1.08e-12 Breast cancer; CRC cis rs7937682 0.924 rs513425 chr11:111504861 C/T cg19812747 chr11:111475976 SIK2 -0.59 -10.07 -0.49 5.54e-21 Primary sclerosing cholangitis; CRC cis rs9368481 0.646 rs75843621 chr6:26967881 G/A cg10547057 chr6:26987810 LOC100270746;C6orf41 -0.41 -5.82 -0.31 1.39e-8 Autism spectrum disorder or schizophrenia; CRC cis rs3008870 0.755 rs2815360 chr1:67494458 C/T cg08660285 chr1:67390436 MIER1;WDR78 0.56 7.89 0.4 4.46e-14 Lymphocyte percentage of white cells; CRC cis rs8180040 0.620 rs11707736 chr3:47069504 G/T cg10298567 chr3:47292165 KIF9 0.39 6.06 0.32 3.64e-9 Colorectal cancer; CRC cis rs9311474 0.508 rs12637627 chr3:52619962 G/T cg05573699 chr3:52720067 GNL3;PBRM1 -0.47 -6.92 -0.36 2.4e-11 Electroencephalogram traits; CRC cis rs2880765 0.835 rs56406982 chr15:86036379 G/A cg17133734 chr15:86042851 AKAP13 0.42 6.54 0.34 2.33e-10 Coronary artery disease; CRC cis rs7208859 0.673 rs216409 chr17:28906269 C/T cg14008862 chr17:28927542 LRRC37B2 -0.5 -6.23 -0.32 1.47e-9 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs7224685 0.501 rs781847 chr17:3958194 G/A cg05562828 chr17:3906858 NA 0.67 12.29 0.56 8.24e-29 Type 2 diabetes; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg19907326 chr13:33002597 N4BP2L1 0.45 6.67 0.35 1.1e-10 Response to antipsychotic treatment; CRC cis rs8141529 0.664 rs5762861 chr22:29250505 T/G cg02153584 chr22:29168773 CCDC117 0.47 6.44 0.33 4.28e-10 Lymphocyte counts; CRC cis rs9902453 0.904 rs8078638 chr17:28290358 A/G cg26525008 chr17:28256777 EFCAB5;SSH2 0.71 12.0 0.55 9.01e-28 Coffee consumption (cups per day); CRC cis rs780096 0.546 rs2911712 chr2:27626945 A/T cg12648201 chr2:27665141 KRTCAP3 -0.3 -5.94 -0.31 7.33e-9 Total body bone mineral density; CRC trans rs6550704 0.687 rs9865314 chr3:22634337 A/G cg02114082 chr10:12306459 NA -0.41 -6.24 -0.33 1.35e-9 Daytime sleep phenotypes; CRC cis rs1799949 0.930 rs66499067 chr17:41248484 G/C cg19454999 chr17:41278357 BRCA1;NBR2 0.54 8.28 0.42 3.09e-15 Menopause (age at onset); CRC cis rs11190604 0.767 rs10509743 chr10:102190406 C/T cg07080220 chr10:102295463 HIF1AN 0.47 5.75 0.3 2.08e-8 Palmitoleic acid (16:1n-7) levels; CRC cis rs10504229 0.683 rs11786523 chr8:58131319 G/C cg21724239 chr8:58056113 NA 0.49 6.81 0.35 4.75e-11 Developmental language disorder (linguistic errors); CRC cis rs4969178 0.600 rs4969184 chr17:76393413 G/A cg02319466 chr17:76381040 PGS1 0.38 6.05 0.32 3.95e-9 HDL cholesterol levels; CRC trans rs35110281 0.805 rs4818843 chr21:45006607 C/T cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.48 7.96 0.4 2.88e-14 Mean corpuscular volume; CRC cis rs4665809 0.627 rs35461456 chr2:26482361 C/G cg08067268 chr2:26466485 HADHB;HADHA 0.66 8.38 0.42 1.54e-15 Gut microbiome composition (summer); CRC cis rs2404602 0.692 rs60658665 chr15:77042508 T/C cg03037974 chr15:76606532 NA 0.69 11.69 0.54 1.23e-26 Blood metabolite levels; CRC cis rs798554 0.797 rs35957220 chr7:2812632 C/G cg13628971 chr7:2884303 GNA12 0.53 6.96 0.36 1.9e-11 Height; CRC cis rs6121246 0.865 rs6058421 chr20:30295013 G/C cg07809909 chr20:30433512 FOXS1 0.35 5.74 0.3 2.19e-8 Mean corpuscular hemoglobin; CRC cis rs3815700 1.000 rs8104729 chr19:33093979 C/T cg02997394 chr19:33096574 ANKRD27 0.75 8.68 0.43 1.88e-16 Eosinophilic esophagitis; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg15985400 chr11:76091674 PRKRIR -0.43 -6.33 -0.33 8.2e-10 Myopia (pathological); CRC cis rs28386778 0.863 rs7221573 chr17:61859390 G/A cg11494091 chr17:61959527 GH2 0.59 10.04 0.48 7.33e-21 Prudent dietary pattern; CRC cis rs897080 0.515 rs2850290 chr2:44636055 A/G cg04920474 chr2:44395004 PPM1B 0.41 5.73 0.3 2.32e-8 Height; CRC cis rs35306767 0.903 rs12249828 chr10:894838 C/T cg20503657 chr10:835505 NA 0.84 10.66 0.51 5.53e-23 Eosinophil percentage of granulocytes; CRC cis rs7580658 0.724 rs12623948 chr2:128001342 G/A cg09760422 chr2:128146352 NA -0.36 -7.1 -0.36 7.51e-12 Protein C levels; CRC trans rs9409565 0.717 rs61470662 chr9:97189472 T/C cg05679027 chr9:99775184 HIATL2 -0.4 -6.09 -0.32 3.07e-9 Colorectal cancer (alcohol consumption interaction); CRC cis rs7666738 0.861 rs13139309 chr4:99020916 A/G cg05340658 chr4:99064831 C4orf37 0.61 9.51 0.46 4.05e-19 Colonoscopy-negative controls vs population controls; CRC cis rs4908768 0.501 rs6668508 chr1:8574118 C/T cg20416874 chr1:8611966 RERE -0.45 -6.46 -0.34 3.66e-10 Neuroticism (multi-trait analysis);Subjective well-being (multi-trait analysis); CRC cis rs12431410 0.550 rs12896125 chr14:60202416 T/C cg00846580 chr14:60632234 DHRS7 -0.38 -5.67 -0.3 3.07e-8 Schizophrenia; CRC cis rs889398 0.594 rs1466863 chr16:69904138 A/T cg00738113 chr16:70207722 CLEC18C 0.32 5.76 0.3 1.92e-8 Body mass index; CRC cis rs910187 0.605 rs62201430 chr20:45808227 A/T cg27589058 chr20:45804311 EYA2 -0.4 -7.69 -0.39 1.7e-13 Migraine; CRC cis rs7811142 1.000 rs6975729 chr7:100028187 C/T cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.63 8.1 0.41 1.1e-14 Platelet count; CRC cis rs2976388 0.609 rs2257796 chr8:143808667 T/C cg20041105 chr8:143859282 LYNX1 0.47 8.27 0.41 3.44e-15 Urinary tract infection frequency; CRC cis rs2839186 0.739 rs7282763 chr21:47696800 C/T cg09417038 chr21:47716443 C21orf57 -0.42 -6.94 -0.36 2.06e-11 Testicular germ cell tumor; CRC cis rs12681287 0.608 rs13272148 chr8:87481853 T/C cg27223183 chr8:87520930 FAM82B -0.53 -7.52 -0.38 5.31e-13 Caudate activity during reward; CRC cis rs9467773 0.526 rs10946817 chr6:26364056 C/T cg14345882 chr6:26364793 BTN3A2 0.42 6.56 0.34 2.13e-10 Intelligence (multi-trait analysis); CRC cis rs17428076 0.556 rs12692976 chr2:172684403 G/T cg13550731 chr2:172543902 DYNC1I2 -0.58 -7.78 -0.39 9.52e-14 Myopia; CRC cis rs2732480 0.577 rs2634680 chr12:48734564 T/C cg21466736 chr12:48725269 NA -0.61 -9.06 -0.45 1.18e-17 Hemoglobin concentration;Red blood cell count;Hematocrit; CRC cis rs3823572 0.542 rs62470448 chr7:133635618 T/A cg03336402 chr7:133662267 EXOC4 0.68 10.4 0.5 4.22e-22 Intelligence (multi-trait analysis); CRC cis rs4423214 0.879 rs1792264 chr11:71150247 C/T cg13043300 chr11:71146211 DHCR7 -0.46 -6.35 -0.33 7.16e-10 Vitamin D levels; CRC cis rs2072499 0.966 rs2984615 chr1:156165317 G/C cg24450063 chr1:156163899 SLC25A44 1.15 27.57 0.84 1.66e-87 Testicular germ cell tumor; CRC cis rs7584330 0.504 rs11890255 chr2:238434605 A/G cg14458575 chr2:238380390 NA 0.5 6.56 0.34 2.03e-10 Prostate cancer; CRC cis rs1577917 0.837 rs806529 chr6:86467121 C/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.52 -7.11 -0.36 7.42e-12 Response to antipsychotic treatment; CRC cis rs13191362 1.000 rs35593345 chr6:163174981 G/C cg21926612 chr6:163149169 PACRG;PARK2 0.98 12.71 0.57 2.18e-30 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs7429990 0.803 rs6776963 chr3:47830741 A/C cg11946769 chr3:48343235 NME6 -0.45 -5.74 -0.3 2.1e-8 Educational attainment (years of education); CRC trans rs8002861 0.664 rs2184882 chr13:44450346 C/T cg17145862 chr1:211918768 LPGAT1 0.55 9.8 0.48 4.6e-20 Leprosy; CRC cis rs13323323 0.691 rs9815769 chr3:44663014 A/T cg11003573 chr3:44754125 ZNF502 -0.41 -5.85 -0.31 1.18e-8 IgG glycosylation; CRC cis rs753778 0.628 rs11579 chr8:142205132 G/A cg23750338 chr8:142222470 SLC45A4 0.45 7.61 0.39 2.88e-13 Reticulocyte fraction of red cells;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; CRC cis rs875971 0.964 rs6978429 chr7:65959876 T/G cg18912574 chr7:65842487 NCRNA00174 0.35 6.09 0.32 3.11e-9 Aortic root size; CRC trans rs12495832 0.778 rs736658 chr3:147935768 T/C cg10221266 chr7:153579447 NA 0.56 6.12 0.32 2.6e-9 Chin dimples; CRC cis rs6840360 0.550 rs62327349 chr4:152627230 G/C cg09659197 chr4:152720779 NA 0.32 5.82 0.31 1.39e-8 Intelligence (multi-trait analysis); CRC cis rs4434138 0.594 rs7653028 chr3:52763000 A/T cg05573699 chr3:52720067 GNL3;PBRM1 -0.45 -6.67 -0.35 1.05e-10 Intelligence (multi-trait analysis); CRC cis rs62229266 0.682 rs2835224 chr21:37370030 A/T cg12218747 chr21:37451666 NA -0.42 -7.08 -0.36 8.98e-12 Mitral valve prolapse; CRC trans rs7671189 0.502 rs10939368 chr4:11740262 C/T cg18054620 chr5:111191530 C5orf13 -0.3 -6.04 -0.32 4.16e-9 Obesity-related traits; CRC cis rs2013441 1.000 rs8074047 chr17:20176703 G/A cg13482628 chr17:19912719 NA -0.41 -6.3 -0.33 9.31e-10 Obesity-related traits; CRC cis rs4481887 0.504 rs4916113 chr1:248377292 C/T cg00666640 chr1:248458726 OR2T12 0.4 6.88 0.35 3.08e-11 Common traits (Other); CRC cis rs796364 0.806 rs10931889 chr2:201101900 G/T cg25936922 chr2:200820526 C2orf60;C2orf47 -0.61 -5.69 -0.3 2.79e-8 Schizophrenia; CRC cis rs11971779 0.585 rs3922848 chr7:139046210 T/C cg23387468 chr7:139079360 LUC7L2 0.4 6.96 0.36 1.9e-11 Diisocyanate-induced asthma; CRC cis rs2976388 0.609 rs1560986 chr8:143789775 T/C cg04969067 chr8:143858791 LYNX1 0.45 7.67 0.39 1.97e-13 Urinary tract infection frequency; CRC cis rs2243480 1.000 rs313807 chr7:65499481 C/T cg25985355 chr7:65971099 NA -0.5 -5.74 -0.3 2.13e-8 Diabetic kidney disease; CRC cis rs798554 0.759 rs2644291 chr7:2890456 T/C cg13628971 chr7:2884303 GNA12 0.6 7.98 0.4 2.51e-14 Height; CRC cis rs4727027 0.933 rs4725800 chr7:148862516 C/G cg23583168 chr7:148888333 NA -0.85 -14.49 -0.62 3.9e-37 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC cis rs7394190 0.748 rs78985317 chr10:75514465 C/T cg07699608 chr10:75541558 CHCHD1 0.68 6.69 0.35 9.59e-11 Incident atrial fibrillation; CRC cis rs9287719 0.870 rs728135 chr2:10745132 A/C cg00105475 chr2:10696890 NA 0.45 7.21 0.37 3.91e-12 Prostate cancer; CRC cis rs4478858 0.746 rs10914328 chr1:31688406 A/G cg00250761 chr1:31883323 NA 0.31 5.88 0.31 1.01e-8 Alcohol dependence; CRC cis rs600231 0.542 rs11227199 chr11:65238121 G/A cg17120908 chr11:65337727 SSSCA1 -0.68 -7.56 -0.38 4.09e-13 Bone mineral density; CRC cis rs7618501 0.633 rs12496973 chr3:50002245 T/C cg05623727 chr3:50126028 RBM5 0.45 7.6 0.39 3.11e-13 Intelligence (multi-trait analysis); CRC cis rs1448094 0.512 rs10779216 chr12:86240315 A/G cg25456477 chr12:86230367 RASSF9 -0.34 -5.92 -0.31 8.24e-9 Major depressive disorder; CRC cis rs4332037 0.707 rs10268797 chr7:1873756 C/G cg25834613 chr7:1915315 MAD1L1 0.41 6.25 0.33 1.27e-9 Bipolar disorder; CRC cis rs6502050 0.765 rs6502075 chr17:80121813 G/A cg11859384 chr17:80120422 CCDC57 -0.36 -5.75 -0.3 2.07e-8 Life satisfaction; CRC cis rs7666738 0.830 rs10009943 chr4:99021475 G/A cg17366294 chr4:99064904 C4orf37 0.43 7.29 0.37 2.28e-12 Colonoscopy-negative controls vs population controls; CRC cis rs1129187 0.755 rs7760250 chr6:42929839 G/A cg03790207 chr6:42947109 PEX6 -0.51 -7.51 -0.38 5.62e-13 Alzheimer's disease in APOE e4+ carriers; CRC trans rs6665290 0.669 rs3795446 chr1:227180981 C/T cg20698410 chr1:19661425 NA -0.27 -5.97 -0.31 6.12e-9 Myeloid white cell count; CRC cis rs6952808 0.575 rs6950330 chr7:1953606 T/C cg14004847 chr7:1930337 MAD1L1 -0.41 -6.14 -0.32 2.34e-9 Bipolar disorder and schizophrenia; CRC cis rs9427116 0.677 rs9426831 chr1:154609657 A/T cg17218026 chr1:154582156 ADAR -0.62 -10.11 -0.49 4.1e-21 Blood protein levels; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg00177013 chr20:62339100 ARFRP1;ZGPAT 0.47 6.07 0.32 3.48e-9 Thyroid stimulating hormone; CRC cis rs992157 0.560 rs7605980 chr2:219100869 C/G cg04731861 chr2:219085781 ARPC2 -0.36 -7.79 -0.39 8.76e-14 Colorectal cancer; CRC cis rs4665809 0.590 rs5001914 chr2:26415429 A/G cg08067268 chr2:26466485 HADHB;HADHA -0.66 -8.43 -0.42 1.08e-15 Gut microbiome composition (summer); CRC cis rs9911578 0.967 rs7502208 chr17:57165097 G/A cg05425664 chr17:57184151 TRIM37 -0.51 -8.04 -0.41 1.61e-14 Intelligence (multi-trait analysis); CRC cis rs2243480 1.000 rs67536397 chr7:65947917 G/A cg12463550 chr7:65579703 CRCP 0.65 5.72 0.3 2.4e-8 Diabetic kidney disease; CRC cis rs7224737 1.000 rs11079034 chr17:40288890 G/A cg20291162 chr17:40259547 DHX58 -0.55 -8.15 -0.41 7.84e-15 Fibrinogen levels; CRC cis rs9368481 0.569 rs10946868 chr6:26887930 A/G cg05192639 chr6:26864778 GUSBL1 0.34 6.04 0.32 4.27e-9 Autism spectrum disorder or schizophrenia; CRC cis rs17152411 1.000 rs7914110 chr10:126599886 C/G cg07906193 chr10:126599966 NA 0.62 6.87 0.35 3.18e-11 Height; CRC cis rs4805272 0.626 rs12608533 chr19:29331405 C/G cg12667521 chr19:29218732 NA 0.43 6.33 0.33 8.23e-10 Plasma omega-3 polyunsaturated fatty acid levels (docosahexaenoic acid); CRC cis rs3126085 0.825 rs11204933 chr1:152172185 C/T cg09127314 chr1:152161683 NA 0.52 6.52 0.34 2.67e-10 Atopic dermatitis; CRC cis rs9611565 0.512 rs4820444 chr22:42202606 A/G cg06634786 chr22:41940651 POLR3H 0.67 7.73 0.39 1.29e-13 Vitiligo; CRC cis rs2239547 0.562 rs35380116 chr3:52979178 A/G cg18404041 chr3:52824283 ITIH1 0.33 6.62 0.34 1.42e-10 Schizophrenia; CRC cis rs11025559 0.812 rs10833336 chr11:20514288 C/G cg19653624 chr11:20408972 PRMT3 -0.55 -6.78 -0.35 5.68e-11 Pursuit maintenance gain; CRC cis rs7811142 1.000 rs67163493 chr7:100023838 C/T cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.75 10.19 0.49 2.27e-21 Platelet count; CRC cis rs6604026 0.656 rs2481712 chr1:93351477 G/A cg17283838 chr1:93427260 FAM69A -0.42 -5.63 -0.3 3.87e-8 Multiple sclerosis; CRC cis rs2625529 0.652 rs2957735 chr15:72265173 T/C cg16672083 chr15:72433130 SENP8 0.47 7.1 0.36 7.52e-12 Red blood cell count; CRC cis rs4665809 0.590 rs10179959 chr2:26426403 G/A cg27170947 chr2:26402098 FAM59B -0.61 -7.91 -0.4 3.85e-14 Gut microbiome composition (summer); CRC trans rs2303319 0.504 rs58622044 chr2:162596287 A/G cg22902534 chr3:183892754 AP2M1 -0.72 -6.24 -0.33 1.32e-9 Cognitive function; CRC trans rs7615952 0.641 rs4422257 chr3:125774363 A/G cg07211511 chr3:129823064 LOC729375 -0.72 -9.7 -0.47 9.79e-20 Blood pressure (smoking interaction); CRC cis rs561341 0.505 rs28708703 chr17:30386845 C/G cg23018236 chr17:30244563 NA -0.49 -6.49 -0.34 3.24e-10 Hip circumference adjusted for BMI; CRC cis rs7772486 0.686 rs6570705 chr6:145961201 C/T cg13319975 chr6:146136371 FBXO30 -0.42 -6.32 -0.33 8.6e-10 Lobe attachment (rater-scored or self-reported); CRC cis rs7639513 0.737 rs13070228 chr3:12706914 G/A cg23032965 chr3:12705835 RAF1 0.66 10.29 0.49 1.02e-21 Itch intensity from mosquito bite; CRC cis rs9549328 0.520 rs36144023 chr13:113616592 T/C cg08614441 chr13:113633676 MCF2L 0.4 6.97 0.36 1.69e-11 Systolic blood pressure; CRC cis rs1552244 0.872 rs6792951 chr3:10119603 C/A cg10729496 chr3:10149963 C3orf24 0.5 6.77 0.35 5.95e-11 Alzheimer's disease; CRC cis rs7617773 0.780 rs6442111 chr3:48312060 G/C cg11946769 chr3:48343235 NME6 0.63 8.73 0.43 1.31e-16 Coronary artery disease; CRC cis rs7666738 0.830 rs13148324 chr4:98833616 G/A cg05340658 chr4:99064831 C4orf37 0.53 7.69 0.39 1.73e-13 Colonoscopy-negative controls vs population controls; CRC cis rs1728785 1.000 rs1170428 chr16:68603988 C/A cg02972257 chr16:68554789 NA -0.66 -7.89 -0.4 4.55e-14 Ulcerative colitis; CRC cis rs6951245 1.000 rs75016635 chr7:1094121 G/A cg07217954 chr7:1067459 C7orf50 0.55 5.71 0.3 2.48e-8 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs1552244 1.000 rs55822690 chr3:10128003 A/G cg16606324 chr3:10149918 C3orf24 0.74 10.05 0.48 6.58e-21 Alzheimer's disease; CRC cis rs2303745 0.841 rs10409801 chr19:17407415 A/G cg04248312 chr19:17393744 ANKLE1 -0.88 -11.01 -0.52 3.27e-24 Systemic lupus erythematosus; CRC cis rs2204008 0.745 rs12146863 chr12:38502346 G/A cg26384229 chr12:38710491 ALG10B 0.71 10.1 0.49 4.6e-21 Bladder cancer; CRC cis rs2976388 0.609 rs2717602 chr8:143805683 G/A cg22687807 chr8:143858763 LYNX1 0.5 8.88 0.44 4.38e-17 Urinary tract infection frequency; CRC cis rs1046896 0.553 rs8073413 chr17:80836005 G/A cg03160526 chr17:80928410 B3GNTL1 0.58 7.75 0.39 1.13e-13 Glycated hemoglobin levels; CRC trans rs208520 0.789 rs9351549 chr6:66871851 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.02 -14.02 -0.61 2.54e-35 Exhaled nitric oxide output; CRC cis rs17767392 0.958 rs55883127 chr14:71980236 G/A cg13720639 chr14:72061746 SIPA1L1 -0.57 -7.26 -0.37 2.77e-12 Mitral valve prolapse; CRC cis rs4481887 0.927 rs10888343 chr1:248446642 A/G cg00666640 chr1:248458726 OR2T12 0.57 10.01 0.48 9.09e-21 Common traits (Other); CRC cis rs11098499 0.863 rs34868248 chr4:120442430 A/G cg09307838 chr4:120376055 NA 0.68 10.31 0.49 8.81e-22 Corneal astigmatism; CRC cis rs2839186 0.708 rs6518285 chr21:47644667 T/C cg13126279 chr21:47581558 C21orf56 -0.52 -8.47 -0.42 8.39e-16 Testicular germ cell tumor; CRC cis rs6952808 0.624 rs60137119 chr7:2083664 A/G cg20295408 chr7:1910781 MAD1L1 -0.43 -5.73 -0.3 2.21e-8 Bipolar disorder and schizophrenia; CRC cis rs1322639 0.668 rs9766666 chr6:169613541 G/T cg04662567 chr6:169592167 NA -0.36 -6.1 -0.32 2.92e-9 Pulse pressure; CRC cis rs6032067 0.929 rs45461302 chr20:43805274 G/A cg10761708 chr20:43804764 PI3 0.51 5.79 0.3 1.62e-8 Blood protein levels; CRC cis rs875971 0.545 rs17138149 chr7:65693180 A/G cg18876405 chr7:65276391 NA 0.45 6.31 0.33 9.26e-10 Aortic root size; CRC cis rs10876993 0.928 rs2928053 chr12:58063475 T/C cg15848620 chr12:58087721 OS9 -0.63 -8.95 -0.44 2.73e-17 Celiac disease or Rheumatoid arthritis; CRC cis rs3733585 0.605 rs4235355 chr4:10123078 C/A cg00071950 chr4:10020882 SLC2A9 -0.58 -9.38 -0.46 1.08e-18 Cleft plate (environmental tobacco smoke interaction); CRC cis rs4664293 0.647 rs1549385 chr2:160439051 C/T cg08347373 chr2:160653686 CD302 -0.39 -6.53 -0.34 2.57e-10 Monocyte percentage of white cells; CRC cis rs2239547 0.522 rs2581815 chr3:52982159 C/G cg11645453 chr3:52864694 ITIH4 0.51 9.76 0.47 6.05e-20 Schizophrenia; CRC cis rs2153535 0.580 rs6421948 chr6:8531020 T/C cg21535247 chr6:8435926 SLC35B3 0.48 7.4 0.38 1.12e-12 Motion sickness; CRC cis rs8105895 0.935 rs8108651 chr19:22251464 A/G cg02657401 chr19:22469223 NA -0.34 -5.65 -0.3 3.56e-8 Body mass index (change over time); CRC trans rs12714314 0.560 rs11694545 chr2:1939208 C/T cg01355875 chr4:10118935 WDR1 0.47 5.97 0.31 6.29e-9 Type 2 diabetes (age of onset); CRC cis rs7264396 0.561 rs66483315 chr20:34573575 C/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.55 -8.72 -0.43 1.38e-16 Total cholesterol levels; CRC cis rs9556958 0.708 rs9513435 chr13:99160334 C/G cg20750642 chr13:99100586 FARP1 0.41 6.22 0.32 1.53e-9 Educational attainment (years of education); CRC cis rs2651899 0.902 rs1798246 chr1:3080855 A/C cg22674798 chr1:3096360 PRDM16 0.34 7.0 0.36 1.43e-11 Migraine; CRC trans rs634534 0.562 rs661335 chr11:65754061 G/A cg17712092 chr4:129076599 LARP1B 0.66 10.77 0.51 2.27e-23 Sum eosinophil basophil counts;Eosinophil counts; CRC cis rs11608355 1.000 rs3742020 chr12:109883254 T/C cg19025524 chr12:109796872 NA -0.48 -6.97 -0.36 1.7e-11 Neuroticism; CRC cis rs10504229 0.679 rs11783963 chr8:58130496 T/A cg02725872 chr8:58115012 NA -0.64 -11.55 -0.54 3.85e-26 Developmental language disorder (linguistic errors); CRC cis rs11229555 0.574 rs12292024 chr11:58186716 C/T cg15696309 chr11:58395628 NA -0.82 -10.31 -0.49 8.59e-22 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; CRC cis rs2976388 0.590 rs13254346 chr8:143823863 G/C cg10596483 chr8:143751796 JRK -0.45 -6.4 -0.33 5.49e-10 Urinary tract infection frequency; CRC cis rs9522267 0.535 rs9522296 chr13:112234340 C/T cg14352298 chr13:112236639 NA -0.29 -6.67 -0.35 1.09e-10 Hepatitis; CRC trans rs3780486 0.505 rs10217267 chr9:33146528 T/C cg20290983 chr6:43655470 MRPS18A 0.93 16.14 0.66 1.36e-43 IgG glycosylation; CRC cis rs1707322 0.752 rs61784798 chr1:46173481 C/T cg03146154 chr1:46216737 IPP 0.67 9.73 0.47 7.77e-20 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs9649213 0.593 rs6944262 chr7:97985415 T/G cg00277769 chr7:97922759 BAIAP2L1 -0.6 -10.52 -0.5 1.68e-22 Prostate cancer (SNP x SNP interaction); CRC cis rs477895 0.653 rs11231701 chr11:63893702 G/A cg19465662 chr11:63993652 NUDT22;TRPT1 0.74 9.11 0.45 8.02e-18 Mean platelet volume; CRC cis rs965469 1.000 rs6139103 chr20:3361140 T/C cg25506879 chr20:3388711 C20orf194 -0.39 -5.63 -0.3 3.89e-8 IFN-related cytopenia; CRC cis rs2257205 0.667 rs7213035 chr17:56857281 A/G cg25885038 chr17:56607967 SEPT4 -0.53 -5.75 -0.3 2.07e-8 Pancreatic cancer; CRC cis rs561341 1.000 rs561341 chr17:30316385 T/G cg23018236 chr17:30244563 NA -0.67 -8.02 -0.4 1.83e-14 Hip circumference adjusted for BMI; CRC cis rs1475911 1.000 rs2839465 chr21:43511232 C/T cg19766460 chr21:43528205 UMODL1;C21orf128 0.68 7.94 0.4 3.33e-14 IgG glycosylation; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg21925064 chr5:148724958 GRPEL2 0.39 6.11 0.32 2.75e-9 Intelligence (multi-trait analysis); CRC cis rs1862618 0.853 rs860580 chr5:56149429 G/T cg20203395 chr5:56204925 C5orf35 0.69 8.31 0.42 2.63e-15 Initial pursuit acceleration; CRC cis rs7487075 0.820 rs7967549 chr12:46723692 G/A cg22049899 chr12:47219821 SLC38A4 0.34 6.61 0.34 1.58e-10 Itch intensity from mosquito bite; CRC cis rs1656402 1.000 rs1190444 chr2:233421679 G/A cg03852847 chr2:233439513 NA 0.42 6.95 0.36 1.95e-11 Non-small cell lung cancer (survival); CRC cis rs2404602 0.716 rs17362383 chr15:76650702 A/G cg22467129 chr15:76604101 ETFA -0.45 -7.53 -0.38 4.99e-13 Blood metabolite levels; CRC cis rs9814567 1.000 rs6769885 chr3:134286913 G/C cg06541857 chr3:134203789 ANAPC13;CEP63 -0.38 -5.7 -0.3 2.62e-8 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg09765074 chr10:69634185 NA 0.45 6.99 0.36 1.54e-11 Myopia (pathological); CRC cis rs870825 0.549 rs7656993 chr4:185635159 T/C cg04058563 chr4:185651563 MLF1IP 0.73 9.38 0.46 1.13e-18 Blood protein levels; CRC cis rs2985684 1.000 rs2985687 chr14:50100386 T/C cg04989706 chr14:50066350 PPIL5 -0.49 -6.92 -0.36 2.32e-11 Carotid intima media thickness; CRC cis rs477895 0.838 rs11607007 chr11:64007976 C/T cg18225595 chr11:63971243 STIP1 0.62 7.82 0.4 7.38e-14 Mean platelet volume; CRC cis rs2739330 0.760 rs1007888 chr22:24241101 C/T cg23131131 chr22:24373011 LOC391322 -0.62 -9.5 -0.46 4.35e-19 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs9733 0.596 rs72702573 chr1:150689050 C/T cg18016565 chr1:150552671 MCL1 0.45 6.52 0.34 2.57e-10 Tonsillectomy; CRC cis rs3823572 0.526 rs2971966 chr7:133642559 A/G cg03336402 chr7:133662267 EXOC4 -0.66 -10.27 -0.49 1.22e-21 Intelligence (multi-trait analysis); CRC cis rs7605827 0.930 rs2380657 chr2:15678482 T/C cg19274914 chr2:15703543 NA 0.38 5.8 0.3 1.59e-8 Educational attainment (years of education); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg27051171 chr2:7005923 CMPK2 0.4 6.53 0.34 2.49e-10 Liver disease severity in Alagille syndrome; CRC cis rs4919694 0.901 rs12251035 chr10:104671459 A/C cg04362960 chr10:104952993 NT5C2 1.12 10.35 0.5 6.61e-22 Arsenic metabolism; CRC cis rs10504229 0.911 rs77203035 chr8:58175458 C/A cg01721255 chr8:58191610 C8orf71 0.49 6.17 0.32 2e-9 Developmental language disorder (linguistic errors); CRC cis rs2932538 0.885 rs6693880 chr1:113110261 A/G cg22162597 chr1:113214053 CAPZA1 0.71 10.25 0.49 1.43e-21 Systolic blood pressure;Diastolic blood pressure;Hypertension;Blood pressure; CRC cis rs9733 0.596 rs12403255 chr1:150660412 C/T cg15448220 chr1:150897856 SETDB1 0.45 6.45 0.33 4.03e-10 Tonsillectomy; CRC cis rs853679 0.546 rs200953 chr6:27837267 T/C cg03623178 chr6:28175578 NA 0.78 6.83 0.35 4.03e-11 Depression; CRC cis rs1552244 1.000 rs17032299 chr3:10087638 C/T cg02579736 chr3:10068473 FANCD2;CIDECP 0.98 13.22 0.59 2.63e-32 Alzheimer's disease; CRC cis rs12122100 0.545 rs1984615 chr1:146506206 G/A cg02487331 chr1:146550467 NA -0.34 -6.11 -0.32 2.78e-9 HIV-1 control; CRC cis rs4964805 0.626 rs11111771 chr12:104179271 A/G cg02344784 chr12:104178138 NT5DC3 -0.54 -8.02 -0.4 1.82e-14 Attention deficit hyperactivity disorder; CRC cis rs7493 0.853 rs17166879 chr7:95053415 A/G cg21856205 chr7:94953877 PON1 -0.52 -6.57 -0.34 2.01e-10 Yu-Zhi constitution type in type 2 diabetes; CRC trans rs7647973 0.626 rs9870858 chr3:49769071 C/T cg21665057 chr3:196295764 WDR53;FBXO45 -0.61 -6.87 -0.35 3.25e-11 Menarche (age at onset); CRC cis rs4713118 0.515 rs9368549 chr6:28050047 T/A cg21251018 chr6:28226885 NKAPL 0.47 6.23 0.33 1.39e-9 Parkinson's disease; CRC cis rs490234 0.783 rs28729336 chr9:128405488 T/G cg14078157 chr9:128172775 NA -0.41 -6.83 -0.35 4.12e-11 Mean arterial pressure; CRC cis rs7568458 0.660 rs2289972 chr2:85766545 C/T cg02493740 chr2:85810744 VAMP5 -0.55 -8.3 -0.42 2.68e-15 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); CRC cis rs875971 1.000 rs4717300 chr7:65947380 T/C cg12463550 chr7:65579703 CRCP 0.47 6.71 0.35 8.75e-11 Aortic root size; CRC cis rs9393692 0.905 rs7746807 chr6:26293338 C/A cg00631329 chr6:26305371 NA -0.7 -13.51 -0.6 2.24e-33 Educational attainment; CRC cis rs12980942 0.872 rs12327659 chr19:41796472 A/G cg25627403 chr19:41769009 HNRNPUL1 0.46 5.77 0.3 1.79e-8 Coronary artery disease; CRC cis rs7215564 0.908 rs35128297 chr17:78652909 A/C cg09596252 chr17:78655493 RPTOR 0.54 5.7 0.3 2.7e-8 Myopia (pathological); CRC cis rs7605827 0.893 rs6733695 chr2:15525714 T/C cg19274914 chr2:15703543 NA 0.39 5.9 0.31 8.92e-9 Educational attainment (years of education); CRC cis rs9534288 0.763 rs34175925 chr13:46611800 G/A cg15192986 chr13:46630673 CPB2 -0.68 -9.89 -0.48 2.31e-20 Blood protein levels; CRC cis rs7772486 0.641 rs2777485 chr6:146334377 G/A cg13319975 chr6:146136371 FBXO30 -0.55 -7.72 -0.39 1.41e-13 Lobe attachment (rater-scored or self-reported); CRC cis rs941408 1.000 rs1736180 chr19:2796021 C/T cg06609049 chr19:2785107 THOP1 0.64 9.7 0.47 1.03e-19 Total cholesterol levels; CRC cis rs6694672 0.867 rs10737687 chr1:197108693 C/T cg13682187 chr1:196946512 CFHR5 0.42 6.72 0.35 8.15e-11 Asthma; CRC cis rs501120 0.925 rs492152 chr10:44757677 C/T cg09554077 chr10:44749378 NA 0.78 11.8 0.55 5e-27 Coronary artery disease;Coronary heart disease; CRC cis rs8180040 0.966 rs4858868 chr3:47455086 G/A cg10298567 chr3:47292165 KIF9 -0.35 -5.82 -0.31 1.36e-8 Colorectal cancer; CRC cis rs3750965 0.959 rs11228490 chr11:68860872 C/G cg06818126 chr11:68850279 TPCN2 0.45 6.37 0.33 6.47e-10 Hair color; CRC cis rs858239 1.000 rs858240 chr7:23284237 A/G cg00469287 chr7:23338798 C7orf30 0.42 5.65 0.3 3.48e-8 Cerebrospinal fluid biomarker levels; CRC cis rs55702914 0.628 rs17730989 chr2:198362524 C/T cg10820045 chr2:198174542 NA 0.34 6.14 0.32 2.35e-9 Major depression and alcohol dependence; CRC cis rs11628318 0.713 rs4900543 chr14:103029024 T/C cg23071808 chr14:103021642 NA -0.71 -9.34 -0.46 1.53e-18 Platelet count; CRC cis rs72781680 1.000 rs72796339 chr2:24143063 T/C cg08917208 chr2:24149416 ATAD2B 0.91 9.24 0.45 3.06e-18 Lymphocyte counts; CRC cis rs7412746 0.587 rs3849279 chr1:150944707 T/C cg15448220 chr1:150897856 SETDB1 0.46 6.69 0.35 9.34e-11 Melanoma; CRC cis rs4665809 0.590 rs2891496 chr2:26452605 G/A cg27170947 chr2:26402098 FAM59B 0.6 7.82 0.4 7.45e-14 Gut microbiome composition (summer); CRC cis rs861020 0.677 rs2049998 chr1:210031154 C/T cg09163369 chr1:210001066 C1orf107 -0.57 -7.18 -0.37 4.62e-12 Orofacial clefts; CRC cis rs9462027 0.628 rs9462006 chr6:34710327 C/G cg07306190 chr6:34760872 UHRF1BP1 -0.34 -6.07 -0.32 3.49e-9 Systemic lupus erythematosus; CRC trans rs7726839 0.540 rs72703079 chr5:595173 T/C cg11887960 chr12:57824829 NA 0.59 6.68 0.35 1.01e-10 Obesity-related traits; CRC cis rs611744 0.647 rs676654 chr8:109242303 A/G cg18478394 chr8:109455254 TTC35 0.41 6.16 0.32 2.15e-9 Dupuytren's disease; CRC cis rs798554 0.683 rs1182155 chr7:2902890 C/G cg19346786 chr7:2764209 NA -0.32 -5.7 -0.3 2.63e-8 Height; CRC cis rs6860806 0.507 rs2631371 chr5:131703691 G/A cg04518342 chr5:131593106 PDLIM4 -0.44 -7.15 -0.37 5.59e-12 Breast cancer; CRC cis rs651907 0.557 rs11710533 chr3:101351472 G/A cg11279151 chr3:101281821 RG9MTD1 -0.57 -7.69 -0.39 1.7e-13 Colorectal cancer; CRC cis rs3772130 1.000 rs62268732 chr3:121370455 T/G cg20356878 chr3:121714668 ILDR1 0.49 7.58 0.39 3.64e-13 Cognitive performance; CRC cis rs9926296 0.712 rs258332 chr16:89727683 G/A cg01097406 chr16:89675127 NA 0.52 9.63 0.47 1.63e-19 Vitiligo; CRC cis rs2976388 0.524 rs7012804 chr8:143844650 A/G cg12516270 chr8:143859308 LYNX1 0.59 10.82 0.51 1.56e-23 Urinary tract infection frequency; CRC cis rs1552244 1.000 rs2272125 chr3:10138069 A/C cg16606324 chr3:10149918 C3orf24 0.68 9.74 0.47 7.42e-20 Alzheimer's disease; CRC cis rs7605378 0.528 rs281787 chr2:200784238 C/T cg23649088 chr2:200775458 C2orf69 -0.71 -11.6 -0.54 2.56e-26 Osteoporosis; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg02185971 chr7:6388334 C7orf70 0.42 6.43 0.33 4.46e-10 Liver disease severity in Alagille syndrome; CRC cis rs2239547 0.618 rs4687658 chr3:52860366 C/G cg15147215 chr3:52552868 STAB1 -0.43 -6.09 -0.32 3.12e-9 Schizophrenia; CRC cis rs13191362 1.000 rs34228197 chr6:163008232 A/G cg23758597 chr6:163146217 PARK2 -0.51 -5.9 -0.31 8.81e-9 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs7617773 0.780 rs13066044 chr3:48377276 C/T cg11946769 chr3:48343235 NME6 0.74 9.91 0.48 2.03e-20 Coronary artery disease; CRC cis rs875971 0.895 rs1974769 chr7:65950614 G/A cg18912574 chr7:65842487 NCRNA00174 0.36 6.1 0.32 2.99e-9 Aortic root size; CRC cis rs1005277 0.579 rs1780139 chr10:38503018 C/T cg25517755 chr10:38738941 LOC399744 -0.4 -5.91 -0.31 8.75e-9 Extrinsic epigenetic age acceleration; CRC cis rs7666738 0.830 rs7687958 chr4:99014495 T/C cg17366294 chr4:99064904 C4orf37 0.44 7.35 0.38 1.55e-12 Colonoscopy-negative controls vs population controls; CRC trans rs10411161 0.702 rs8110461 chr19:52383569 A/C cg22319618 chr22:45562946 NUP50 -0.68 -7.53 -0.38 4.85e-13 Breast cancer; CRC trans rs10504229 1.000 rs77857677 chr8:58170131 G/A cg04077850 chr5:125800366 GRAMD3 0.37 6.27 0.33 1.15e-9 Developmental language disorder (linguistic errors); CRC cis rs1401999 0.510 rs2293001 chr3:183700211 C/T cg05044414 chr3:183734942 ABCC5 0.35 5.81 0.31 1.44e-8 Anterior chamber depth; CRC cis rs7635838 0.596 rs13353463 chr3:11260221 T/C cg00170343 chr3:11313890 ATG7 0.53 8.13 0.41 8.78e-15 HDL cholesterol; CRC cis rs7605827 0.930 rs6718736 chr2:15525875 C/T cg19274914 chr2:15703543 NA 0.39 5.87 0.31 1.05e-8 Educational attainment (years of education); CRC cis rs929596 0.561 rs6431625 chr2:234637912 T/C cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.58 -9.19 -0.45 4.51e-18 Total bilirubin levels in HIV-1 infection; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg14748682 chr11:6624841 ILK;RRP8 0.36 5.96 0.31 6.33e-9 Liver disease severity in Alagille syndrome; CRC cis rs9549367 0.713 rs576463 chr13:113846614 C/T cg18105134 chr13:113819100 PROZ 0.85 13.44 0.6 3.84e-33 Platelet distribution width; CRC cis rs231513 0.954 rs425135 chr17:41984517 A/C cg26893861 chr17:41843967 DUSP3 -0.64 -6.49 -0.34 3.16e-10 Cognitive function; CRC cis rs728616 0.614 rs61859198 chr10:82114628 C/A cg11900509 chr10:81946545 ANXA11 -0.57 -6.43 -0.33 4.53e-10 Chronic obstructive pulmonary disease-related biomarkers; CRC trans rs2303319 0.504 rs56009150 chr2:162598582 T/C cg13034943 chr12:132379564 ULK1 -0.69 -5.96 -0.31 6.33e-9 Cognitive function; CRC cis rs477895 0.639 rs35858916 chr11:63950529 T/G cg18225595 chr11:63971243 STIP1 0.61 8.08 0.41 1.23e-14 Mean platelet volume; CRC trans rs1814175 0.817 rs7483795 chr11:49704930 G/A cg15704280 chr7:45808275 SEPT13 -0.99 -19.61 -0.73 3.04e-57 Height; CRC cis rs9517320 0.515 rs4772101 chr13:99207554 G/A cg07423050 chr13:99094983 FARP1 -0.54 -7.6 -0.39 3.12e-13 Longevity; CRC cis rs1577917 0.681 rs4707211 chr6:86232710 G/A cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A 0.5 6.91 0.36 2.58e-11 Response to antipsychotic treatment; CRC cis rs4713118 0.955 rs9468206 chr6:27690453 G/T cg02683197 chr6:28174875 NA 0.58 7.56 0.38 4.16e-13 Parkinson's disease; CRC cis rs7909074 0.831 rs2065466 chr10:45384047 T/C cg04218760 chr10:45406644 TMEM72 -0.34 -9.74 -0.47 7.48e-20 Mean corpuscular volume; CRC cis rs7937682 0.889 rs10789844 chr11:111579109 A/T cg19812747 chr11:111475976 SIK2 -0.55 -9.2 -0.45 4.26e-18 Primary sclerosing cholangitis; CRC cis rs561341 0.505 rs548298 chr17:30297494 C/A cg19193384 chr17:30244184 NA -0.53 -6.66 -0.34 1.15e-10 Hip circumference adjusted for BMI; CRC cis rs9549328 0.589 rs34144481 chr13:113617322 T/G cg24588162 chr13:113633484 MCF2L 0.36 6.5 0.34 2.95e-10 Systolic blood pressure; CRC cis rs7833986 0.534 rs17814089 chr8:56965563 A/G cg23139584 chr8:56987506 RPS20;SNORD54 -0.89 -13.08 -0.58 8.97e-32 Height; CRC cis rs2298450 0.575 rs2268299 chr21:37660161 G/A cg02919814 chr21:37666008 DOPEY2 -0.43 -6.22 -0.32 1.48e-9 Schizophrenia; CRC cis rs4713118 0.869 rs9295743 chr6:27715102 G/C cg02683197 chr6:28174875 NA 0.63 8.77 0.44 9.62e-17 Parkinson's disease; CRC cis rs2243480 1.000 rs6460260 chr7:65215455 T/C cg18252515 chr7:66147081 NA 1.16 13.27 0.59 1.71e-32 Diabetic kidney disease; CRC cis rs6951245 1.000 rs77868187 chr7:1093968 A/C cg21664854 chr7:1097933 C7orf50;GPR146 0.77 8.73 0.43 1.34e-16 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg12789522 chr15:78423758 CIB2 0.4 6.77 0.35 5.8200000000000003e-11 Liver disease severity in Alagille syndrome; CRC cis rs754466 0.580 rs10762763 chr10:79560803 C/G cg26805224 chr10:79626177 DLG5 -0.39 -5.82 -0.31 1.41e-8 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs902774 0.530 rs12819597 chr12:53353956 T/C cg05393297 chr12:53359155 NA -1.06 -10.23 -0.49 1.6e-21 Prostate cancer; CRC cis rs11098499 0.908 rs11729050 chr4:120300066 T/C cg09307838 chr4:120376055 NA 0.71 10.93 0.52 6.41e-24 Corneal astigmatism; CRC cis rs763014 0.932 rs35067229 chr16:649638 T/C cg02475695 chr16:616220 NHLRC4 0.47 7.84 0.4 6.12e-14 Height; CRC cis rs7301826 0.651 rs4759519 chr12:131289508 G/A cg11011512 chr12:131303247 STX2 0.37 5.6 0.3 4.44e-8 Plasma plasminogen activator levels; CRC trans rs35110281 0.782 rs9981291 chr21:45031458 A/G cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.5 8.28 0.42 3.2e-15 Mean corpuscular volume; CRC cis rs2836950 0.565 rs8134214 chr21:40542367 A/C cg11890956 chr21:40555474 PSMG1 -0.68 -10.4 -0.5 4.37e-22 Menarche (age at onset); CRC cis rs1816752 0.905 rs6490929 chr13:25014252 G/A cg02811702 chr13:24901961 NA 0.47 6.55 0.34 2.16e-10 Obesity-related traits; CRC cis rs10504229 0.683 rs55807014 chr8:58131801 T/C cg22535103 chr8:58192502 C8orf71 -0.7 -9.34 -0.46 1.47e-18 Developmental language disorder (linguistic errors); CRC cis rs2839186 0.508 rs6518278 chr21:47640571 A/G cg12516959 chr21:47718080 NA 0.42 6.78 0.35 5.45e-11 Testicular germ cell tumor; CRC cis rs4713118 0.786 rs200503 chr6:27785882 A/G cg02683197 chr6:28174875 NA 0.64 7.86 0.4 5.59e-14 Parkinson's disease; CRC cis rs7937840 0.501 rs4963459 chr11:61877137 G/A cg01969543 chr11:61895209 INCENP -0.52 -7.46 -0.38 7.59e-13 Breast cancer; CRC cis rs4474465 0.850 rs10793332 chr11:78270020 C/G cg27205649 chr11:78285834 NARS2 0.48 6.25 0.33 1.28e-9 Alzheimer's disease (survival time); CRC cis rs4711350 1.000 rs2395447 chr6:33743174 T/C cg07979401 chr6:33739406 LEMD2 -0.47 -5.78 -0.3 1.71e-8 Schizophrenia; CRC cis rs10504229 0.815 rs16921955 chr8:58164553 C/T cg02290350 chr8:58132656 NA -0.44 -6.59 -0.34 1.75e-10 Developmental language disorder (linguistic errors); CRC cis rs2019137 0.936 rs3828189 chr2:113954496 T/A cg11763394 chr2:113992921 PAX8;LOC440839;LOC654433 -0.49 -7.08 -0.36 9.03e-12 Lymphocyte counts; CRC cis rs873946 0.586 rs61862838 chr10:134572282 C/T cg06453172 chr10:134556979 INPP5A -0.66 -7.92 -0.4 3.71e-14 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CRC cis rs694739 0.687 rs11231771 chr11:64140642 T/G cg02228329 chr11:64053129 BAD;GPR137 0.5 6.79 0.35 5.31e-11 Alopecia areata;Crohn's disease;Psoriasis vulgaris; CRC trans rs3733585 0.673 rs6449156 chr4:9956712 G/C cg26043149 chr18:55253948 FECH -0.49 -7.61 -0.39 2.86e-13 Cleft plate (environmental tobacco smoke interaction); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg23666278 chr2:171785822 GORASP2 0.37 6.75 0.35 6.62e-11 Liver disease severity in Alagille syndrome; CRC cis rs3741404 0.560 rs2875748 chr11:63915537 G/A cg18225595 chr11:63971243 STIP1 -0.47 -7.58 -0.39 3.55e-13 Platelet count; CRC cis rs875971 0.862 rs10950033 chr7:65739673 A/G cg18876405 chr7:65276391 NA -0.5 -8.2 -0.41 5.45e-15 Aortic root size; CRC cis rs713587 0.563 rs2384057 chr2:25100167 C/G cg22495460 chr2:25135724 ADCY3 -0.87 -16.6 -0.68 2.16e-45 Body mass index in non-asthmatics; CRC cis rs7107174 1.000 rs2450128 chr11:77940075 G/A cg02023728 chr11:77925099 USP35 0.53 8.94 0.44 2.81e-17 Testicular germ cell tumor; CRC cis rs9649213 0.574 rs12873 chr7:97922773 T/C cg24562669 chr7:97807699 LMTK2 0.45 7.6 0.39 3.16e-13 Prostate cancer (SNP x SNP interaction); CRC trans rs747782 0.528 rs16905753 chr11:48285906 C/T cg03929089 chr4:120376271 NA 0.68 6.93 0.36 2.2e-11 Intraocular pressure; CRC cis rs6831352 0.918 rs13112733 chr4:100050319 A/T cg13256891 chr4:100009986 ADH5 -0.66 -8.89 -0.44 4.04e-17 Alcohol dependence; CRC cis rs78456975 0.941 rs13412229 chr2:1520381 C/T cg26248373 chr2:1572462 NA -0.58 -5.98 -0.31 5.67e-9 Placebo response in major depressive disorder (% change in symptom score); CRC cis rs2228479 0.850 rs11647174 chr16:89958538 G/A cg06656553 chr16:89960601 TCF25 -0.69 -6.06 -0.32 3.75e-9 Skin colour saturation; CRC cis rs9649213 0.593 rs6968144 chr7:97915697 G/A cg00277769 chr7:97922759 BAIAP2L1 -0.61 -10.81 -0.51 1.7e-23 Prostate cancer (SNP x SNP interaction); CRC cis rs11098499 0.865 rs1112817 chr4:120297800 T/C cg09307838 chr4:120376055 NA 0.71 10.93 0.52 6.41e-24 Corneal astigmatism; CRC cis rs9659323 0.706 rs1409160 chr1:119583854 C/A cg26570165 chr1:119541833 NA -0.35 -5.83 -0.31 1.32e-8 Body mass index; CRC cis rs970548 0.954 rs11239571 chr10:46087892 A/G cg15590007 chr10:45870220 ALOX5 -0.47 -6.17 -0.32 2.06e-9 Total cholesterol levels;Cholesterol, total;HDL cholesterol;HDL cholesterol levels; CRC trans rs7615952 0.736 rs9866347 chr3:125669925 C/T cg07211511 chr3:129823064 LOC729375 -0.92 -11.52 -0.54 5.2e-26 Blood pressure (smoking interaction); CRC trans rs10838798 0.504 rs11039530 chr11:48145746 C/T cg03929089 chr4:120376271 NA -0.44 -6.16 -0.32 2.18e-9 Height; CRC cis rs6968419 0.714 rs3807980 chr7:115893647 A/G cg02561103 chr7:115862891 TES -0.42 -6.37 -0.33 6.22e-10 Intraocular pressure; CRC cis rs853679 0.607 rs34661125 chr6:28281894 G/A cg26958806 chr6:27640298 NA 0.93 6.56 0.34 2.11e-10 Depression; CRC cis rs79349575 0.715 rs999474 chr17:46987665 G/A cg22482690 chr17:47019901 SNF8 -0.43 -6.95 -0.36 2e-11 Type 2 diabetes; CRC cis rs10256972 0.786 rs3735686 chr7:1062527 G/A cg22907277 chr7:1156413 C7orf50 0.44 6.32 0.33 8.49e-10 Longevity;Endometriosis; CRC trans rs916888 0.738 rs199515 chr17:44856641 C/G cg01341218 chr17:43662625 NA -0.8 -9.15 -0.45 6.2e-18 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs1799949 0.501 rs2343819 chr17:41409653 T/G cg25072359 chr17:41440525 NA 0.45 6.86 0.35 3.32e-11 Menopause (age at onset); CRC cis rs8060686 0.623 rs6499157 chr16:68105474 A/C cg26727032 chr16:67993705 SLC12A4 -0.62 -9.97 -0.48 1.21e-20 HDL cholesterol;Metabolic syndrome; CRC cis rs6445525 0.837 rs9810565 chr3:66003182 A/G cg06109867 chr3:66002991 MAGI1 -0.36 -5.81 -0.31 1.47e-8 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs533581 0.873 rs579740 chr16:88973937 A/G cg09141835 chr16:88988174 CBFA2T3 0.27 6.1 0.32 2.93e-9 Social autistic-like traits; CRC cis rs12594515 1.000 rs8026221 chr15:45987910 G/T cg22117107 chr15:45993392 NA -0.44 -9.09 -0.45 9.56e-18 Waist circumference;Weight; CRC cis rs7517126 1.000 rs34924297 chr1:196865583 G/A cg13682187 chr1:196946512 CFHR5 -0.36 -5.61 -0.3 4.28e-8 Blood protein levels; CRC cis rs769267 0.965 rs2965191 chr19:19453521 T/G cg01262667 chr19:19385393 TM6SF2 -0.37 -6.26 -0.33 1.17e-9 Tonsillectomy; CRC cis rs634534 0.622 rs624273 chr11:65712413 A/G cg17985854 chr11:65770987 BANF1;EIF1AD 0.38 5.95 0.31 6.92e-9 Sum eosinophil basophil counts;Eosinophil counts; CRC cis rs921968 0.541 rs3731867 chr2:219472734 G/A cg02176678 chr2:219576539 TTLL4 -0.61 -9.47 -0.46 5.68e-19 Mean corpuscular hemoglobin concentration; CRC cis rs739401 0.572 rs384490 chr11:3078885 A/C cg05729581 chr11:3078854 CARS -0.57 -8.39 -0.42 1.48e-15 Longevity; CRC cis rs9910055 0.718 rs7212854 chr17:42254417 A/G cg19774624 chr17:42201019 HDAC5 -0.69 -10.26 -0.49 1.34e-21 Total body bone mineral density; CRC cis rs1552244 0.882 rs13099136 chr3:10031431 G/A cg08888203 chr3:10149979 C3orf24 0.62 8.31 0.42 2.58e-15 Alzheimer's disease; CRC cis rs7605827 0.930 rs12692268 chr2:15595519 A/G cg19274914 chr2:15703543 NA 0.4 6.04 0.32 4.18e-9 Educational attainment (years of education); CRC cis rs17401966 1.000 rs12129035 chr1:10291166 G/A cg19773385 chr1:10388646 KIF1B -0.56 -7.86 -0.4 5.59e-14 Hepatocellular carcinoma; CRC cis rs7617773 0.709 rs4404473 chr3:48353626 A/G cg11946769 chr3:48343235 NME6 0.73 9.58 0.47 2.45e-19 Coronary artery disease; CRC cis rs7737355 0.812 rs40991 chr5:131000654 C/A cg06307176 chr5:131281290 NA 0.41 5.89 0.31 9.38e-9 Life satisfaction; CRC cis rs9443645 0.901 rs9361488 chr6:79782874 T/C cg11833968 chr6:79620685 NA -0.35 -6.05 -0.32 3.84e-9 Intelligence (multi-trait analysis); CRC cis rs6938 0.618 rs12911254 chr15:75166335 G/A cg18612461 chr15:75251733 NA 0.37 5.82 0.31 1.43e-8 Breast cancer; CRC cis rs6952808 0.965 rs4719318 chr7:1887930 G/A cg21782813 chr7:2030301 MAD1L1 0.4 6.77 0.35 6.05e-11 Bipolar disorder and schizophrenia; CRC cis rs1552244 0.572 rs6783705 chr3:10164783 A/G cg18598329 chr3:10140678 FANCD2;C3orf24 -0.91 -10.81 -0.51 1.62e-23 Alzheimer's disease; CRC cis rs9847710 0.869 rs2564917 chr3:53037695 C/T cg04503182 chr3:53078218 SFMBT1 0.39 6.14 0.32 2.38e-9 Ulcerative colitis; CRC cis rs17826219 0.636 rs8080829 chr17:29058730 C/T cg13385521 chr17:29058706 SUZ12P 0.69 7.78 0.39 9.29e-14 Body mass index; CRC trans rs2727020 0.595 rs10839286 chr11:49497063 C/A cg03929089 chr4:120376271 NA -0.91 -17.23 -0.69 7.51e-48 Coronary artery disease; CRC trans rs1005277 0.579 rs2983343 chr10:38383332 A/G cg11292332 chr7:45801988 SEPT13 -0.35 -6.26 -0.33 1.23e-9 Extrinsic epigenetic age acceleration; CRC cis rs7113874 0.569 rs4929942 chr11:8625096 A/G cg20771178 chr11:8615675 STK33 0.34 5.73 0.3 2.25e-8 Body mass index in physically active individuals;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs9435341 0.826 rs17496332 chr1:107546375 C/T cg14671364 chr1:107599128 PRMT6 -0.52 -7.02 -0.36 1.28e-11 Facial morphology (factor 21, depth of nasal alae); CRC cis rs853679 0.506 rs1150693 chr6:28174590 T/C cg15845792 chr6:28175446 NA 0.95 13.76 0.6 2.35e-34 Depression; CRC cis rs57590327 0.555 rs6767749 chr3:81725513 G/A cg07356753 chr3:81810745 GBE1 -0.65 -8.88 -0.44 4.33e-17 Extraversion; CRC cis rs1538970 0.884 rs781232 chr1:45890399 C/T cg05343316 chr1:45956843 TESK2 -0.67 -9.23 -0.45 3.41e-18 Platelet count; CRC cis rs8060686 0.641 rs8047119 chr16:68047345 G/C cg26727032 chr16:67993705 SLC12A4 -0.56 -6.22 -0.32 1.54e-9 HDL cholesterol;Metabolic syndrome; CRC cis rs1008375 0.898 rs10008445 chr4:17593978 G/T cg02297831 chr4:17616191 MED28 0.43 5.61 0.3 4.33e-8 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs4535497 0.544 rs4975642 chr5:1107828 G/A cg18655438 chr5:1077845 SLC12A7 0.46 6.7 0.35 9.19e-11 Mean corpuscular hemoglobin concentration; CRC cis rs1707322 1.000 rs11211232 chr1:46411146 C/T cg06784218 chr1:46089804 CCDC17 0.57 10.14 0.49 3.26e-21 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs311392 0.902 rs681000 chr8:55094043 C/T cg06042504 chr8:55087323 NA -0.43 -6.75 -0.35 6.83e-11 Pelvic organ prolapse (moderate/severe); CRC cis rs2239547 0.522 rs9844736 chr3:52931971 T/G cg10802521 chr3:52805072 NEK4 0.48 6.58 0.34 1.8e-10 Schizophrenia; CRC cis rs12580194 0.593 rs4590978 chr12:55725086 G/T cg23425280 chr12:56401806 NA 0.48 5.81 0.31 1.45e-8 Cancer; CRC trans rs1814175 0.645 rs847627 chr11:49927177 G/A cg03929089 chr4:120376271 NA -0.91 -16.07 -0.66 2.65e-43 Height; CRC cis rs1448094 0.511 rs7139088 chr12:86147878 T/C cg02569458 chr12:86230093 RASSF9 -0.48 -8.08 -0.41 1.27e-14 Major depressive disorder; CRC cis rs7043114 0.525 rs9299404 chr9:95170338 A/G cg14631576 chr9:95140430 CENPP 0.32 6.17 0.32 2.02e-9 Height; CRC cis rs9910055 0.502 rs1684662 chr17:42180822 T/A cg19774624 chr17:42201019 HDAC5 0.44 5.9 0.31 8.93e-9 Total body bone mineral density; CRC cis rs12681287 0.605 rs2953509 chr8:87343194 C/T cg27223183 chr8:87520930 FAM82B -0.52 -6.96 -0.36 1.85e-11 Caudate activity during reward; CRC cis rs9467711 0.651 rs35069699 chr6:25957282 C/T cg08501292 chr6:25962987 TRIM38 1.06 9.09 0.45 9.85e-18 Autism spectrum disorder or schizophrenia; CRC cis rs6732160 0.932 rs13417029 chr2:73380423 T/G cg01422370 chr2:73384389 NA 0.33 5.67 0.3 3.17e-8 Intelligence (multi-trait analysis); CRC cis rs7666738 0.830 rs11097582 chr4:98772201 G/A cg17366294 chr4:99064904 C4orf37 0.42 6.87 0.35 3.3e-11 Colonoscopy-negative controls vs population controls; CRC cis rs72945132 0.769 rs11235754 chr11:70136092 C/T cg00319359 chr11:70116639 PPFIA1 0.61 6.78 0.35 5.44e-11 Coronary artery disease; CRC cis rs7666738 0.800 rs13106995 chr4:99028790 A/T cg17366294 chr4:99064904 C4orf37 0.44 7.48 0.38 6.96e-13 Colonoscopy-negative controls vs population controls; CRC cis rs1707322 0.893 rs9919275 chr1:46441360 A/C cg06784218 chr1:46089804 CCDC17 0.51 8.96 0.44 2.39e-17 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs9322193 0.923 rs10872651 chr6:150089409 A/T cg05861140 chr6:150128134 PCMT1 -0.4 -6.23 -0.32 1.46e-9 Lung cancer; CRC cis rs7727544 0.716 rs2089855 chr5:131573529 A/G cg22638593 chr5:131593259 PDLIM4 0.33 5.98 0.31 5.96e-9 Blood metabolite levels; CRC cis rs28386778 0.799 rs2584612 chr17:61932204 A/G cg06601766 chr17:61851465 DDX42;CCDC47 0.42 5.77 0.3 1.86e-8 Prudent dietary pattern; CRC cis rs2115630 0.645 rs3825877 chr15:85174631 G/A cg12501888 chr15:85177176 SCAND2 -0.46 -7.75 -0.39 1.15e-13 P wave terminal force; CRC cis rs9715521 1.000 rs9715521 chr4:59824487 G/A cg11281224 chr4:60001000 NA -0.38 -5.63 -0.3 3.86e-8 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs4969178 0.930 rs12601079 chr17:76400329 G/A cg20026190 chr17:76395443 PGS1 0.38 5.79 0.3 1.65e-8 HDL cholesterol levels; CRC cis rs992157 0.835 rs2292551 chr2:219143229 G/A cg13835894 chr2:219148914 PNKD;TMBIM1 -0.35 -6.76 -0.35 6.22e-11 Colorectal cancer; CRC cis rs9788682 1.000 rs7181245 chr15:78814389 C/T cg06917634 chr15:78832804 PSMA4 -0.48 -5.89 -0.31 9.37e-9 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; CRC cis rs2462686 1.000 rs2462327 chr7:45993039 C/A cg23193639 chr7:45961078 IGFBP3 -0.37 -5.75 -0.3 2.06e-8 Major depressive disorder; CRC cis rs796364 0.806 rs188102 chr2:200903189 T/A cg25936922 chr2:200820526 C2orf60;C2orf47 -0.68 -6.67 -0.34 1.11e-10 Schizophrenia; CRC cis rs6951245 1.000 rs79617366 chr7:1111958 G/C cg03188948 chr7:1209495 NA 0.65 6.85 0.35 3.56e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs2795502 0.935 rs2744060 chr10:43262616 C/G cg13590978 chr10:43134234 ZNF33B 0.71 5.72 0.3 2.38e-8 Blood protein levels; CRC cis rs2857891 1.000 rs2595500 chr11:6963165 C/T cg04053776 chr11:6947353 ZNF215 -0.49 -7.02 -0.36 1.3e-11 Response to cytadine analogues (cytosine arabinoside); CRC cis rs6558530 0.897 rs7838456 chr8:1707591 T/G cg19131313 chr8:1704013 NA -0.44 -5.82 -0.31 1.4e-8 Systolic blood pressure; CRC cis rs1348850 0.958 rs11689550 chr2:178456298 A/G cg22681709 chr2:178499509 PDE11A -0.34 -6.2 -0.32 1.67e-9 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs8005677 0.926 rs34344888 chr14:23387585 A/G cg25600027 chr14:23388339 RBM23 -0.53 -8.3 -0.42 2.72e-15 Cognitive ability (multi-trait analysis); CRC cis rs1707322 1.000 rs12077546 chr1:46431806 C/T cg06784218 chr1:46089804 CCDC17 0.51 9.05 0.45 1.28e-17 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs780096 0.526 rs3845687 chr2:27689899 T/C cg27432699 chr2:27873401 GPN1 -0.57 -8.86 -0.44 5.23e-17 Total body bone mineral density; CRC cis rs17092148 1.000 rs3787220 chr20:33337751 T/C cg08999081 chr20:33150536 PIGU 0.46 5.71 0.3 2.54e-8 Neuroticism; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg11073926 chr1:43855438 MED8;C1orf84 0.36 5.96 0.31 6.44e-9 Liver disease severity in Alagille syndrome; CRC cis rs13108904 0.870 rs2279281 chr4:1245277 T/G cg20887711 chr4:1340912 KIAA1530 0.39 5.69 0.3 2.88e-8 Obesity-related traits; CRC cis rs62103177 0.608 rs4442895 chr18:77826399 C/G cg12964065 chr18:77638022 KCNG2 -0.45 -6.26 -0.33 1.21e-9 Opioid sensitivity; CRC cis rs9948 0.529 rs62156222 chr2:97410988 C/A cg20312557 chr2:97357134 FER1L5 -0.61 -5.67 -0.3 3.19e-8 Erectile dysfunction and prostate cancer treatment; CRC cis rs860295 0.702 rs1556488 chr1:155540660 T/G cg02153340 chr1:155202674 NA -0.51 -6.32 -0.33 8.35e-10 Body mass index; CRC cis rs524281 0.861 rs7929909 chr11:65951698 C/T cg16950941 chr11:66035639 RAB1B -0.6 -7.43 -0.38 9.29e-13 Electroencephalogram traits; CRC trans rs3942852 0.568 rs7479361 chr11:48109793 C/T cg03929089 chr4:120376271 NA -0.55 -7.46 -0.38 7.78e-13 Acute lymphoblastic leukemia (childhood); CRC cis rs9287719 0.967 rs7592691 chr2:10737426 A/G cg00105475 chr2:10696890 NA 0.45 7.3 0.37 2.19e-12 Prostate cancer; CRC cis rs6582630 0.555 rs1969362 chr12:38514843 C/T cg13010199 chr12:38710504 ALG10B 0.48 6.36 0.33 6.94e-10 Drug-induced liver injury (flucloxacillin); CRC cis rs7113874 0.524 rs4612809 chr11:8620038 T/C cg17679104 chr11:8615758 STK33 0.34 5.8 0.3 1.59e-8 Body mass index in physically active individuals;Body mass index (joint analysis main effects and physical activity interaction); CRC trans rs9354352 0.935 rs9354354 chr6:66699333 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.59 -8.78 -0.44 9.36e-17 Initial pursuit acceleration in psychotic disorders; CRC cis rs362272 0.545 rs2236052 chr4:3318413 C/T cg11522145 chr4:3412961 RGS12 0.37 5.77 0.3 1.81e-8 Serum sulfate level; CRC trans rs7826238 0.623 rs2976893 chr8:8338219 G/T cg16141378 chr3:129829833 LOC729375 0.51 7.79 0.39 9.11e-14 Systolic blood pressure; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg12028816 chr17:7232827 NEURL4 0.43 6.9 0.36 2.74e-11 Liver disease severity in Alagille syndrome; CRC cis rs4319547 0.656 rs6488951 chr12:122873928 A/G cg05707623 chr12:122985044 ZCCHC8 -0.73 -8.76 -0.44 1.02e-16 Body mass index; CRC cis rs7615952 1.000 rs7616044 chr3:125649354 G/C cg05084668 chr3:125655381 ALG1L -0.63 -9.78 -0.47 5.24e-20 Blood pressure (smoking interaction); CRC cis rs9902453 0.578 rs8073217 chr17:28164263 G/C cg26525008 chr17:28256777 EFCAB5;SSH2 0.7 11.52 0.54 5.15e-26 Coffee consumption (cups per day); CRC cis rs12530134 0.590 rs760492 chr6:170743989 A/G cg18217622 chr6:170732253 NA 0.66 6.73 0.35 7.4e-11 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs9911578 0.835 rs9889419 chr17:56473259 C/T cg05425664 chr17:57184151 TRIM37 -0.44 -6.77 -0.35 6.01e-11 Intelligence (multi-trait analysis); CRC cis rs1044826 0.642 rs4607068 chr3:139162994 A/G cg00490450 chr3:139108681 COPB2 0.48 7.24 0.37 3.2e-12 Obesity-related traits; CRC cis rs9487051 1.000 rs1341271 chr6:109617542 A/T cg21918786 chr6:109611834 NA -0.37 -6.27 -0.33 1.13e-9 Reticulocyte fraction of red cells; CRC cis rs644799 0.710 rs11021311 chr11:95505227 G/A cg25622487 chr11:95524042 FAM76B;CEP57 0.79 13.17 0.59 4.34e-32 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs1129187 0.967 rs6941212 chr6:42915920 A/G cg02353165 chr6:42928485 GNMT 0.83 15.18 0.64 8.26e-40 Alzheimer's disease in APOE e4+ carriers; CRC cis rs7772486 0.790 rs2265474 chr6:146182092 G/A cg23711669 chr6:146136114 FBXO30 0.78 13.6 0.6 9.97e-34 Lobe attachment (rater-scored or self-reported); CRC cis rs6089584 0.606 rs2273989 chr20:60579138 G/A cg06108461 chr20:60628389 TAF4 -0.64 -10.45 -0.5 2.93e-22 Body mass index; CRC cis rs1003719 0.788 rs2156076 chr21:38452634 G/T cg10648535 chr21:38446584 PIGP;TTC3 0.52 7.24 0.37 3.21e-12 Eye color traits; CRC cis rs13031619 0.950 rs7589966 chr2:3696636 A/G cg25251562 chr2:3704773 ALLC 0.49 6.78 0.35 5.71e-11 Response to inhaled corticosteroid treatment in asthma (change in FEV1); CRC cis rs3785574 0.962 rs2727331 chr17:61926990 G/T cg06873352 chr17:61820015 STRADA 0.47 7.35 0.38 1.59e-12 Height; CRC trans rs2243480 1.000 rs160639 chr7:65579987 C/G cg10756647 chr7:56101905 PSPH 0.73 7.68 0.39 1.79e-13 Diabetic kidney disease; CRC cis rs2228479 0.867 rs11645970 chr16:89958118 G/A cg06558623 chr16:89946397 TCF25 1.06 10.8 0.51 1.79e-23 Skin colour saturation; CRC cis rs9768139 0.733 rs13221388 chr7:158119270 G/A cg25566285 chr7:158114605 PTPRN2 0.47 7.5 0.38 6.01e-13 Calcium levels; CRC cis rs6502050 0.835 rs4789732 chr17:80131382 A/G cg02741985 chr17:80059408 CCDC57 0.44 7.24 0.37 3.25e-12 Life satisfaction; CRC cis rs73200209 0.912 rs59560959 chr12:116476998 C/G cg01776926 chr12:116560359 MED13L -0.5 -6.09 -0.32 3.24e-9 Total body bone mineral density; CRC cis rs174601 0.833 rs174541 chr11:61565908 T/C cg00603274 chr11:61596626 FADS2 -0.43 -6.43 -0.33 4.52e-10 Blood metabolite levels;Red blood cell fatty acid levels;Liver enzyme levels (alkaline phosphatase);Gondoic acid (20:1n-9) levels;Trans fatty acid levels; CRC cis rs10751667 0.643 rs10902245 chr11:953014 C/T cg01483505 chr11:975446 AP2A2 -0.41 -6.7 -0.35 9.25e-11 Alzheimer's disease (late onset); CRC cis rs6952808 0.529 rs73038442 chr7:2139457 C/T cg04267008 chr7:1944627 MAD1L1 -0.67 -9.28 -0.46 2.28e-18 Bipolar disorder and schizophrenia; CRC cis rs17443541 0.507 rs4675699 chr2:200451389 A/C cg03741458 chr2:200468445 NA -0.38 -5.95 -0.31 6.72e-9 Intelligence (multi-trait analysis); CRC cis rs1348850 0.914 rs2060929 chr2:178280031 T/C cg22681709 chr2:178499509 PDE11A -0.41 -7.6 -0.39 3.08e-13 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs2645694 0.533 rs2645681 chr4:77820949 G/A cg03477792 chr4:77819574 ANKRD56 0.44 6.37 0.33 6.51e-10 Emphysema distribution in smoking; CRC cis rs514406 0.708 rs514881 chr1:53336737 A/G cg25767906 chr1:53392781 SCP2 0.51 8.24 0.41 4.17e-15 Monocyte count; CRC cis rs1728785 1.000 rs1364109 chr16:68595505 T/C cg02972257 chr16:68554789 NA -0.6 -7.54 -0.38 4.71e-13 Ulcerative colitis; CRC cis rs911555 0.755 rs4906329 chr14:103942669 A/G cg24130564 chr14:104152367 KLC1 0.42 5.72 0.3 2.46e-8 Intelligence (multi-trait analysis); CRC cis rs72772090 0.539 rs72773947 chr5:96125533 T/A cg17330273 chr5:96107758 CAST;ERAP1 -0.63 -5.96 -0.31 6.43e-9 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs853679 0.517 rs9380056 chr6:28104476 C/T cg23161317 chr6:28129485 ZNF389 0.53 6.54 0.34 2.37e-10 Depression; CRC cis rs11122272 0.735 rs2572251 chr1:231514243 C/T cg06096015 chr1:231504339 EGLN1 0.4 5.95 0.31 6.7e-9 Hemoglobin concentration; CRC cis rs12476592 0.571 rs1031221 chr2:63742810 C/T cg10828910 chr2:63850056 LOC388955 -0.49 -6.14 -0.32 2.38e-9 Childhood ear infection; CRC cis rs6565180 0.791 rs4247355 chr16:30392099 A/G cg01392867 chr16:30410429 ZNF48 0.38 6.09 0.32 3.24e-9 Tonsillectomy; CRC cis rs593982 0.920 rs76925283 chr11:65548108 C/T cg08755490 chr11:65554678 OVOL1 -1.09 -11.23 -0.53 5.66e-25 Atopic dermatitis; CRC cis rs10504229 0.683 rs59528137 chr8:58138565 C/T cg08219700 chr8:58056026 NA 0.56 6.58 0.34 1.91e-10 Developmental language disorder (linguistic errors); CRC cis rs7618501 0.574 rs6765484 chr3:50041313 C/T cg24308560 chr3:49941425 MST1R 0.53 8.95 0.44 2.62e-17 Intelligence (multi-trait analysis); CRC cis rs9372498 0.536 rs62424172 chr6:118777533 C/A cg22561889 chr6:118971681 C6orf204 0.52 6.7 0.35 9.08e-11 Diastolic blood pressure; CRC cis rs7845219 0.544 rs9643352 chr8:95918288 C/T cg16049864 chr8:95962084 TP53INP1 -0.44 -6.69 -0.35 9.62e-11 Type 2 diabetes; CRC cis rs7727544 0.669 rs113823725 chr5:131563501 C/G cg14196790 chr5:131705035 SLC22A5 0.37 6.32 0.33 8.68e-10 Blood metabolite levels; CRC cis rs1577917 1.000 rs12203493 chr6:86758642 C/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.54 -6.64 -0.34 1.29e-10 Response to antipsychotic treatment; CRC cis rs910316 1.000 rs10140851 chr14:75512612 G/A cg08847533 chr14:75593920 NEK9 0.93 17.07 0.69 3.07e-47 Height; CRC cis rs2976388 1.000 rs1045547 chr8:143763757 T/G cg22687807 chr8:143858763 LYNX1 -0.37 -6.56 -0.34 2.06e-10 Urinary tract infection frequency; CRC cis rs3091242 0.933 rs35403885 chr1:25784551 G/A cg20684491 chr1:25596433 NA -0.43 -7.41 -0.38 1.11e-12 Erythrocyte sedimentation rate; CRC cis rs6502050 0.835 rs7502676 chr17:80093433 C/G cg02741985 chr17:80059408 CCDC57 0.42 6.95 0.36 1.96e-11 Life satisfaction; CRC cis rs1552244 0.554 rs58020561 chr3:10054682 A/G cg16606324 chr3:10149918 C3orf24 0.47 6.91 0.36 2.5e-11 Alzheimer's disease; CRC cis rs7618915 0.547 rs12487591 chr3:52642936 A/T cg15147215 chr3:52552868 STAB1 -0.59 -9.77 -0.47 5.68e-20 Bipolar disorder; CRC cis rs941873 0.868 rs2145998 chr10:81121696 T/A cg09469691 chr10:81107165 PPIF 0.49 7.77 0.39 1.01e-13 Height; CRC cis rs11098499 0.863 rs7695620 chr4:120452776 G/A cg09307838 chr4:120376055 NA 0.69 10.34 0.5 6.68e-22 Corneal astigmatism; CRC cis rs9292777 0.720 rs16869934 chr5:40397352 C/T cg09067459 chr5:40385259 NA -0.53 -8.64 -0.43 2.42e-16 Crohn's disease;Multiple sclerosis; CRC cis rs28386778 0.734 rs12946669 chr17:62006007 A/G cg25654072 chr17:61904446 PSMC5;FTSJ3 0.49 7.18 0.37 4.54e-12 Prudent dietary pattern; CRC cis rs1878931 0.624 rs1149492 chr16:3445239 A/G cg26668626 chr16:3451006 ZNF174;ZNF434 -0.6 -7.22 -0.37 3.68e-12 Body mass index (adult); CRC cis rs1215050 0.846 rs1839903 chr4:98791414 C/T cg05340658 chr4:99064831 C4orf37 0.44 6.11 0.32 2.75e-9 Waist-to-hip ratio adjusted for body mass index; CRC trans rs2727020 0.704 rs4144700 chr11:49370834 C/A cg21153622 chr11:89784906 NA -0.41 -6.83 -0.35 4.16e-11 Coronary artery disease; CRC cis rs4319547 0.698 rs10744217 chr12:122942070 A/G cg05707623 chr12:122985044 ZCCHC8 -0.57 -7.23 -0.37 3.43e-12 Body mass index; CRC cis rs1152591 0.967 rs1152589 chr14:64683926 A/T cg23250157 chr14:64679961 SYNE2 -0.45 -6.97 -0.36 1.79e-11 Atrial fibrillation; CRC cis rs12134245 1.000 rs12134245 chr1:92021464 C/T cg07090678 chr1:91966139 CDC7 0.45 6.99 0.36 1.54e-11 Breast cancer; CRC cis rs12500482 0.935 rs12644638 chr4:2413461 C/T cg26605046 chr4:2439731 NA -0.4 -7.01 -0.36 1.33e-11 Cognitive function; CRC cis rs2075371 0.611 rs1862045 chr7:134023412 A/G cg02659138 chr7:134003124 SLC35B4 0.37 5.94 0.31 7.34e-9 Mean platelet volume; CRC cis rs9926296 0.546 rs7187436 chr16:89845110 A/T cg04287289 chr16:89883240 FANCA 0.82 15.01 0.64 3.75e-39 Vitiligo; CRC trans rs2303319 0.504 rs1449641 chr2:162619567 T/C cg22627826 chr19:1240265 ATP5D -0.72 -6.24 -0.33 1.37e-9 Cognitive function; CRC cis rs9287719 0.967 rs4453662 chr2:10739128 G/A cg00105475 chr2:10696890 NA 0.45 7.3 0.37 2.19e-12 Prostate cancer; CRC cis rs270601 0.909 rs2569265 chr5:131704519 T/C cg18758796 chr5:131593413 PDLIM4 -0.41 -6.6 -0.34 1.64e-10 Acylcarnitine levels; CRC cis rs2797160 1.000 rs6927161 chr6:126015954 T/C cg05901451 chr6:126070800 HEY2 0.39 6.06 0.32 3.66e-9 Endometrial cancer; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg04234156 chr10:7860746 TAF3 0.44 6.03 0.32 4.43e-9 Response to antipsychotic treatment; CRC cis rs4665809 0.590 rs962217 chr2:26438276 T/C cg25036284 chr2:26402008 FAM59B -0.61 -7.73 -0.39 1.33e-13 Gut microbiome composition (summer); CRC cis rs6701037 0.625 rs34270511 chr1:175128543 C/T cg00321850 chr1:175162397 KIAA0040 -0.4 -6.69 -0.35 9.5e-11 Alcohol dependence; CRC cis rs7618915 0.501 rs7622694 chr3:52663882 G/A cg18099408 chr3:52552593 STAB1 -0.47 -7.97 -0.4 2.57e-14 Bipolar disorder; CRC cis rs7312933 0.966 rs7977365 chr12:42513127 G/A cg17420585 chr12:42539391 GXYLT1 -0.43 -6.25 -0.33 1.3e-9 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CRC cis rs7098414 0.511 rs12262228 chr10:82160425 C/T cg00277334 chr10:82204260 NA -0.5 -8.17 -0.41 6.89e-15 Post bronchodilator FEV1; CRC cis rs1218582 0.741 rs883718 chr1:154846274 C/T cg16680214 chr1:154839983 KCNN3 -0.49 -9.8 -0.48 4.46e-20 Prostate cancer; CRC cis rs7208859 0.673 rs56846352 chr17:29119188 C/T cg01831904 chr17:28903510 LRRC37B2 -0.52 -5.98 -0.31 5.79e-9 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs739401 0.572 rs12276060 chr11:3015572 A/T cg25174290 chr11:3078921 CARS 0.46 7.12 0.37 6.87e-12 Longevity; CRC cis rs6502050 0.835 rs7213172 chr17:80085703 G/T cg25804541 chr17:80189381 SLC16A3 0.31 5.9 0.31 8.94e-9 Life satisfaction; CRC cis rs1451375 0.617 rs10276473 chr7:50612997 A/C cg18232548 chr7:50535776 DDC -0.48 -6.48 -0.34 3.3e-10 Malaria; CRC cis rs4132509 1.000 rs4565696 chr1:243918083 C/T cg21452805 chr1:244014465 NA 0.48 6.32 0.33 8.33e-10 RR interval (heart rate); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg20172593 chr5:94891168 ARSK;TTC37 0.45 6.23 0.32 1.46e-9 Response to antipsychotic treatment; CRC cis rs11628318 0.614 rs1190338 chr14:103105792 T/G cg12046867 chr14:103022105 NA -0.77 -9.14 -0.45 6.39e-18 Platelet count; CRC cis rs9322193 0.887 rs9767113 chr6:150039293 T/C cg04369109 chr6:150039330 LATS1 -0.42 -5.6 -0.3 4.51e-8 Lung cancer; CRC cis rs9814567 0.928 rs6768323 chr3:134268737 A/C cg06541857 chr3:134203789 ANAPC13;CEP63 0.39 5.74 0.3 2.15e-8 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs514406 0.689 rs7548389 chr1:53404211 C/T cg27535305 chr1:53392650 SCP2 -0.4 -7.18 -0.37 4.71e-12 Monocyte count; CRC cis rs9788333 0.695 rs12871086 chr13:21890224 A/T cg23743428 chr13:21893420 NA -0.43 -8.5 -0.42 6.6e-16 Thiazide-induced adverse metabolic effects in hypertensive patients; CRC cis rs13118159 0.550 rs28733902 chr4:1374789 A/G cg20887711 chr4:1340912 KIAA1530 0.71 10.19 0.49 2.19e-21 Longevity; CRC cis rs10197940 0.662 rs4335940 chr2:152275304 A/G cg19508488 chr2:152266495 RIF1 -0.52 -7.65 -0.39 2.2e-13 Lung cancer; CRC cis rs6952808 0.929 rs2280550 chr7:1976556 G/A cg22963979 chr7:1858916 MAD1L1 -0.54 -7.69 -0.39 1.74e-13 Bipolar disorder and schizophrenia; CRC cis rs7927771 0.832 rs10838704 chr11:47424717 T/C cg18512352 chr11:47633146 NA -0.43 -8.37 -0.42 1.72e-15 Subjective well-being; CRC cis rs2228479 0.850 rs17226973 chr16:89825248 T/C cg06656553 chr16:89960601 TCF25 -0.7 -5.76 -0.3 1.93e-8 Skin colour saturation; CRC cis rs9914988 0.887 rs11080072 chr17:27081160 G/T cg20469991 chr17:27169893 C17orf63 -0.48 -6.09 -0.32 3.08e-9 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs2032447 0.839 rs9356995 chr6:25996673 G/A cg04800585 chr6:26043546 HIST1H2BB 0.56 8.52 0.42 5.98e-16 Intelligence (multi-trait analysis); CRC cis rs7772486 0.875 rs854145 chr6:146349650 C/T cg23711669 chr6:146136114 FBXO30 0.67 11.77 0.54 6.32e-27 Lobe attachment (rater-scored or self-reported); CRC cis rs12711979 0.509 rs10200764 chr2:3827772 C/G cg17052675 chr2:3827356 NA -0.86 -20.99 -0.76 1.12e-62 Itch intensity from mosquito bite adjusted by bite size; CRC cis rs881375 0.967 rs2239658 chr9:123671837 A/G cg14255062 chr9:123606675 PSMD5;LOC253039 0.39 5.7 0.3 2.66e-8 Rheumatoid arthritis; CRC cis rs10751667 1.000 rs6597965 chr11:964476 A/G cg23136738 chr11:925521 AP2A2 -0.51 -8.24 -0.41 4.15e-15 Alzheimer's disease (late onset); CRC cis rs12701220 0.655 rs6463317 chr7:1159243 G/A cg02869364 chr7:1081709 C7orf50 -0.46 -6.23 -0.32 1.4e-9 Bronchopulmonary dysplasia; CRC cis rs9611565 0.649 rs139553 chr22:42187199 A/G cg03806693 chr22:41940476 POLR3H 0.69 9.47 0.46 5.58e-19 Vitiligo; CRC cis rs13118159 0.801 rs7664474 chr4:1329116 T/A cg15763984 chr4:1342303 KIAA1530 0.48 8.35 0.42 1.97e-15 Longevity; CRC cis rs1448094 0.817 rs10863122 chr12:86346047 T/C cg00310523 chr12:86230176 RASSF9 0.45 7.54 0.38 4.49e-13 Major depressive disorder; CRC cis rs523522 0.962 rs4767904 chr12:120930798 T/G cg27279351 chr12:120934652 DYNLL1 0.75 11.35 0.53 2.12e-25 High light scatter reticulocyte count; CRC cis rs7666738 0.710 rs7674407 chr4:98838522 A/G cg17366294 chr4:99064904 C4orf37 0.42 6.66 0.34 1.12e-10 Colonoscopy-negative controls vs population controls; CRC cis rs3785574 0.962 rs2665840 chr17:61873307 C/T cg22520471 chr17:61851767 DDX42;CCDC47 -0.46 -6.54 -0.34 2.33e-10 Height; CRC trans rs2727020 0.688 rs4929894 chr11:49196333 G/C cg03929089 chr4:120376271 NA -0.78 -13.01 -0.58 1.67e-31 Coronary artery disease; CRC cis rs4713118 0.869 rs9468214 chr6:27713299 G/C cg06470822 chr6:28175283 NA 0.72 10.13 0.49 3.53e-21 Parkinson's disease; CRC cis rs12479064 0.724 rs6748200 chr2:100080895 G/A cg14399236 chr2:99771627 LIPT1;TSGA10 -0.66 -8.18 -0.41 6.11e-15 Chronic sinus infection; CRC cis rs9308731 0.644 rs1439287 chr2:111871897 G/A cg04202892 chr2:111875749 ACOXL 0.42 6.79 0.35 5.3e-11 Chronic lymphocytic leukemia; CRC cis rs7811142 0.830 rs6945952 chr7:99981775 A/G cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.94 12.65 0.57 3.55e-30 Platelet count; CRC cis rs12369635 0.929 rs3851667 chr12:129550552 G/T cg01909103 chr12:129572610 TMEM132D 0.74 7.27 0.37 2.65e-12 Schizophrenia (inflammation and infection response interaction); CRC cis rs1552244 0.882 rs13063929 chr3:10010308 T/C cg18598329 chr3:10140678 FANCD2;C3orf24 -0.81 -10.63 -0.51 6.98e-23 Alzheimer's disease; CRC cis rs2836950 0.565 rs2150414 chr21:40614988 A/G cg11890956 chr21:40555474 PSMG1 -0.63 -9.15 -0.45 6.12e-18 Menarche (age at onset); CRC cis rs9635542 0.920 rs759196 chr16:5006078 C/T cg06510647 chr16:5006106 NA -0.62 -6.64 -0.34 1.3100000000000001e-10 Lung cancer (asbestos exposure interaction);Cancer; CRC cis rs908922 0.651 rs4240886 chr1:152530396 A/T cg23254163 chr1:152506842 NA -0.45 -9.14 -0.45 6.52e-18 Hair morphology; CRC cis rs10883723 0.810 rs7912901 chr10:104277440 T/C cg22532475 chr10:104410764 TRIM8 -0.36 -6.79 -0.35 5.16e-11 Allergic disease (asthma, hay fever or eczema); CRC cis rs11838776 0.586 rs750598 chr13:111028978 C/T cg06243866 chr13:111019493 COL4A2 -0.4 -6.12 -0.32 2.7e-9 Coronary artery disease; CRC cis rs7786808 0.741 rs4909222 chr7:158228095 C/T cg15440763 chr7:158190612 PTPRN2 -0.41 -6.51 -0.34 2.8e-10 Obesity-related traits; CRC cis rs6662572 0.737 rs56368769 chr1:46451739 A/G cg08644498 chr1:46502608 NA 0.46 7.09 0.36 8.14e-12 Blood protein levels; CRC cis rs1129187 0.755 rs9471976 chr6:42920549 G/T cg00597713 chr6:42947103 PEX6 -0.4 -5.67 -0.3 3.16e-8 Alzheimer's disease in APOE e4+ carriers; CRC cis rs4713118 0.523 rs2179096 chr6:27665920 C/T cg26587870 chr6:27730563 NA -0.38 -6.06 -0.32 3.81e-9 Parkinson's disease; CRC cis rs11623869 0.711 rs2403173 chr14:103909289 T/C cg12935359 chr14:103987150 CKB -0.47 -7.63 -0.39 2.58e-13 Bone mineral density; CRC cis rs9399135 0.967 rs6923765 chr6:135335176 C/G cg24558204 chr6:135376177 HBS1L -0.49 -7.68 -0.39 1.83e-13 Red blood cell count; CRC cis rs9911578 1.000 rs1971659 chr17:57004787 A/G cg05425664 chr17:57184151 TRIM37 -0.49 -7.66 -0.39 2.14e-13 Intelligence (multi-trait analysis); CRC cis rs3768617 0.510 rs1413388 chr1:183096694 T/C ch.1.3577855R chr1:183094577 LAMC1 0.89 15.86 0.66 1.84e-42 Fuchs's corneal dystrophy; CRC cis rs9611519 0.964 rs4820428 chr22:41537589 C/T cg06634786 chr22:41940651 POLR3H 0.44 5.76 0.3 1.97e-8 Neuroticism; CRC cis rs9916302 0.861 rs4795377 chr17:37669056 C/T cg15445000 chr17:37608096 MED1 0.43 9.59 0.47 2.25e-19 Glomerular filtration rate (creatinine); CRC cis rs11764590 0.671 rs12669370 chr7:2081914 G/A cg23422044 chr7:1970798 MAD1L1 -0.43 -6.04 -0.32 4.12e-9 Neuroticism; CRC cis rs8180040 0.800 rs62248905 chr3:47274082 A/G cg02527881 chr3:46936655 PTH1R 0.35 5.98 0.31 5.85e-9 Colorectal cancer; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg08755283 chr5:118324104 DTWD2 0.47 7.78 0.39 9.29e-14 Liver disease severity in Alagille syndrome; CRC cis rs2976388 0.609 rs2572899 chr8:143785549 A/G cg15511327 chr8:143859410 LYNX1 0.41 7.33 0.37 1.81e-12 Urinary tract infection frequency; CRC cis rs9560113 1.000 rs61967684 chr13:112178026 G/C cg10483660 chr13:112241077 NA 0.37 5.97 0.31 5.99e-9 Menarche (age at onset); CRC cis rs780096 0.546 rs1060525 chr2:27635582 A/G cg12648201 chr2:27665141 KRTCAP3 -0.28 -5.6 -0.3 4.49e-8 Total body bone mineral density; CRC cis rs9649213 0.593 rs7796611 chr7:97908223 A/G cg21770322 chr7:97807741 LMTK2 0.56 9.36 0.46 1.33e-18 Prostate cancer (SNP x SNP interaction); CRC trans rs459571 0.959 rs408307 chr9:136892523 A/G cg15028160 chr19:49622717 PPFIA3;C19orf73 0.54 6.78 0.35 5.46e-11 Platelet distribution width; CRC cis rs7617773 0.780 rs34946886 chr3:48338487 A/G cg11946769 chr3:48343235 NME6 0.73 9.93 0.48 1.73e-20 Coronary artery disease; CRC cis rs868036 0.915 rs4489954 chr15:68072075 A/C cg05925327 chr15:68127851 NA 0.32 6.04 0.32 4.13e-9 Restless legs syndrome; CRC cis rs2439831 0.850 rs56909447 chr15:44137618 G/A cg02155558 chr15:43621948 ADAL;LCMT2 0.65 7.16 0.37 5.44e-12 Lung cancer in ever smokers; CRC cis rs4654899 0.929 rs7515845 chr1:21314455 G/A cg02927042 chr1:21476669 EIF4G3 -0.49 -7.92 -0.4 3.64e-14 Superior frontal gyrus grey matter volume; CRC trans rs57221529 0.766 rs72703065 chr5:588123 C/A cg25482853 chr8:67687455 SGK3 1.24 14.83 0.63 1.93e-38 Lung disease severity in cystic fibrosis; CRC cis rs6741819 0.740 rs1797554 chr2:7131854 G/A cg27144453 chr2:7172511 RNF144A -0.39 -5.68 -0.3 2.99e-8 Response to antipsychotic treatment; CRC cis rs6502050 0.799 rs6502066 chr17:80103737 T/C cg25804541 chr17:80189381 SLC16A3 -0.31 -5.97 -0.31 6.08e-9 Life satisfaction; CRC cis rs9322193 1.000 rs9377228 chr6:149921998 G/A cg07701084 chr6:150067640 NUP43 0.54 7.96 0.4 2.81e-14 Lung cancer; CRC trans rs1005277 0.579 rs176880 chr10:38401417 C/G cg11292332 chr7:45801988 SEPT13 0.35 6.23 0.32 1.44e-9 Extrinsic epigenetic age acceleration; CRC cis rs4237845 0.804 rs10877034 chr12:58286444 T/C cg00677455 chr12:58241039 CTDSP2 0.57 8.41 0.42 1.23e-15 Intelligence (multi-trait analysis); CRC cis rs847577 0.630 rs6969384 chr7:97732842 C/T cg21770322 chr7:97807741 LMTK2 0.85 19.36 0.73 2.8e-56 Breast cancer; CRC cis rs17401966 0.838 rs4623 chr1:10366692 C/G cg19773385 chr1:10388646 KIF1B -0.65 -10.63 -0.51 6.72e-23 Hepatocellular carcinoma; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg11050527 chr8:54755511 ATP6V1H 0.43 6.11 0.32 2.84e-9 Response to antipsychotic treatment; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg21308111 chr8:23082634 TNFRSF10A 0.48 6.31 0.33 8.86e-10 Thyroid stimulating hormone; CRC cis rs7208859 0.673 rs73263755 chr17:29198972 A/G cg13385521 chr17:29058706 SUZ12P 0.69 8.01 0.4 2.02e-14 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs3772130 0.962 rs9812228 chr3:121495682 C/G cg20356878 chr3:121714668 ILDR1 0.51 8.05 0.41 1.53e-14 Cognitive performance; CRC cis rs4664304 0.966 rs925411 chr2:160745785 G/T cg03641300 chr2:160917029 PLA2R1 -0.42 -5.94 -0.31 7.15e-9 Crohn's disease;Inflammatory bowel disease; CRC cis rs208520 0.690 rs74707865 chr6:66717352 A/G cg07460842 chr6:66804631 NA 1.06 14.77 0.63 3.26e-38 Exhaled nitric oxide output; CRC cis rs7584330 0.554 rs80151891 chr2:238398826 G/T cg14458575 chr2:238380390 NA 0.81 10.27 0.49 1.22e-21 Prostate cancer; CRC cis rs2386661 0.547 rs72781996 chr10:5646485 C/G cg12223502 chr10:5658492 NA -0.37 -5.9 -0.31 8.99e-9 Breast cancer; CRC cis rs7412746 0.587 rs3849279 chr1:150944707 T/C cg10589385 chr1:150898437 SETDB1 0.27 5.82 0.31 1.41e-8 Melanoma; CRC cis rs72781680 0.716 rs72788284 chr2:24097539 A/G cg08917208 chr2:24149416 ATAD2B 0.55 6.65 0.34 1.25e-10 Lymphocyte counts; CRC cis rs10504229 0.683 rs2318148 chr8:58114955 G/A cg21724239 chr8:58056113 NA 0.49 6.79 0.35 5.28e-11 Developmental language disorder (linguistic errors); CRC cis rs7580658 0.963 rs4233583 chr2:128060068 C/A cg09760422 chr2:128146352 NA -0.36 -7.0 -0.36 1.4e-11 Protein C levels; CRC cis rs10504229 0.610 rs6987118 chr8:58147851 G/T cg05313129 chr8:58192883 C8orf71 -0.42 -6.27 -0.33 1.17e-9 Developmental language disorder (linguistic errors); CRC cis rs6504622 0.537 rs1662596 chr17:44993118 C/T cg16759221 chr17:45003025 GOSR2 -0.69 -11.08 -0.52 1.87e-24 Orofacial clefts; CRC cis rs1552244 0.572 rs66514627 chr3:10166632 A/C cg08888203 chr3:10149979 C3orf24 0.71 8.57 0.43 4.18e-16 Alzheimer's disease; CRC cis rs4253772 0.637 rs9627350 chr22:46663017 A/G cg09491104 chr22:46646882 C22orf40 -0.48 -7.02 -0.36 1.31e-11 LDL cholesterol;Cholesterol, total; CRC cis rs62229266 0.633 rs34259635 chr21:37403570 T/G cg08632701 chr21:37451849 NA -0.41 -6.33 -0.33 8.07e-10 Mitral valve prolapse; CRC trans rs11098499 0.644 rs10012252 chr4:120559139 T/C cg25214090 chr10:38739885 LOC399744 0.55 8.63 0.43 2.62e-16 Corneal astigmatism; CRC cis rs12477438 0.748 rs4851185 chr2:99666497 G/A cg26064155 chr2:99771622 LIPT1;TSGA10 -0.63 -8.55 -0.43 4.61e-16 Chronic sinus infection; CRC cis rs4862750 0.872 rs6830426 chr4:187897270 T/A cg11301795 chr4:187892539 NA -0.87 -19.83 -0.74 4.13e-58 Lobe attachment (rater-scored or self-reported); CRC cis rs68170813 0.559 rs4515482 chr7:107072681 A/C cg23293999 chr7:106826042 HBP1 -0.5 -5.83 -0.31 1.31e-8 Coronary artery disease; CRC cis rs13108904 0.870 rs13132584 chr4:1251504 G/T cg20887711 chr4:1340912 KIAA1530 0.41 5.86 0.31 1.1e-8 Obesity-related traits; CRC cis rs6570726 0.764 rs76635693 chr6:145834070 T/C cg05347473 chr6:146136440 FBXO30 0.4 6.23 0.32 1.45e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs294883 0.739 rs4709292 chr6:159730274 C/T cg14500486 chr6:159655392 FNDC1 -0.36 -6.19 -0.32 1.81e-9 Coronary artery disease; CRC cis rs9914988 0.832 rs35033748 chr17:27179590 T/C cg16670446 chr17:27188758 MIR451;MIR144 0.6 10.0 0.48 9.73e-21 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs933688 1.000 rs11959525 chr5:90703840 A/G cg26981201 chr5:90679533 LOC100129716;ARRDC3 1.02 15.5 0.65 4.63e-41 Smoking behavior; CRC cis rs597539 0.552 rs6591361 chr11:68719284 T/C cg21963583 chr11:68658836 MRPL21 0.53 9.45 0.46 6.61e-19 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs524281 0.773 rs2298468 chr11:66042962 G/A cg16950941 chr11:66035639 RAB1B -0.72 -8.16 -0.41 7.42e-15 Electroencephalogram traits; CRC cis rs7119 0.745 rs12911649 chr15:77807127 C/T cg10437265 chr15:77819839 NA 0.67 11.95 0.55 1.41e-27 Type 2 diabetes; CRC cis rs908922 0.651 rs6671924 chr1:152485830 T/C cg09873164 chr1:152488093 CRCT1 0.33 5.63 0.3 3.89e-8 Hair morphology; CRC cis rs6582630 0.502 rs11522899 chr12:38270637 T/C cg26384229 chr12:38710491 ALG10B 0.69 9.22 0.45 3.69e-18 Drug-induced liver injury (flucloxacillin); CRC cis rs7762018 0.505 rs79843499 chr6:170068420 A/G cg24289452 chr6:170231220 NA -0.78 -6.91 -0.36 2.57e-11 Thiazide-induced adverse metabolic effects in hypertensive patients; CRC trans rs877282 0.891 rs10904557 chr10:797490 C/T cg22713356 chr15:30763199 NA -1.3 -16.58 -0.67 2.75e-45 Uric acid levels; CRC cis rs10463316 0.862 rs11740475 chr5:150777997 A/G cg03212797 chr5:150827313 SLC36A1 -0.48 -7.54 -0.38 4.49e-13 Metabolite levels (Pyroglutamine); CRC cis rs1949733 0.636 rs16842498 chr4:8539529 C/T cg11789530 chr4:8429930 ACOX3 -0.59 -7.99 -0.4 2.28e-14 Response to antineoplastic agents; CRC cis rs9902453 0.868 rs7212162 chr17:28321328 T/A cg26525008 chr17:28256777 EFCAB5;SSH2 0.74 12.51 0.57 1.2e-29 Coffee consumption (cups per day); CRC cis rs7246657 0.943 rs13343471 chr19:37932130 A/G cg23950597 chr19:37808831 NA -0.53 -6.36 -0.33 6.72e-10 Coronary artery calcification; CRC cis rs35306767 0.715 rs1871622 chr10:1049309 T/G cg20503657 chr10:835505 NA 0.93 11.11 0.52 1.43e-24 Eosinophil percentage of granulocytes; CRC cis rs6860806 0.507 rs274572 chr5:131710917 T/G cg11843238 chr5:131593191 PDLIM4 -0.44 -7.37 -0.38 1.36e-12 Breast cancer; CRC cis rs875971 0.540 rs781152 chr7:65479572 T/A cg05627663 chr7:65219948 SNORA22;CCT6P1 0.43 6.07 0.32 3.47e-9 Aortic root size; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg25101273 chr2:196522935 SLC39A10 0.46 6.47 0.34 3.59e-10 Response to antipsychotic treatment; CRC cis rs17767392 0.881 rs34993988 chr14:71923692 C/T cg13720639 chr14:72061746 SIPA1L1 -0.56 -7.16 -0.37 5.3e-12 Mitral valve prolapse; CRC cis rs10752881 0.875 rs10797825 chr1:183024581 G/A ch.1.3577855R chr1:183094577 LAMC1 0.83 14.62 0.63 1.24e-37 Colorectal cancer; CRC trans rs561341 1.000 rs55736640 chr17:30333848 G/A cg27661571 chr11:113659931 NA -0.96 -11.08 -0.52 1.9e-24 Hip circumference adjusted for BMI; CRC cis rs1448094 0.512 rs11832503 chr12:86240797 A/G cg02569458 chr12:86230093 RASSF9 0.43 7.34 0.38 1.68e-12 Major depressive disorder; CRC cis rs2228479 0.850 rs11645240 chr16:89837326 T/C cg19635926 chr16:89946313 TCF25 0.62 5.73 0.3 2.3e-8 Skin colour saturation; CRC cis rs2463822 1.000 rs12279819 chr11:62137245 G/A cg06239285 chr11:62104954 ASRGL1 -0.99 -10.76 -0.51 2.5e-23 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs10754283 0.967 rs10737706 chr1:90112579 G/T cg21401794 chr1:90099060 LRRC8C 0.4 5.71 0.3 2.5e-8 Amyotrophic lateral sclerosis (sporadic); CRC cis rs1552244 0.872 rs7646073 chr3:10097405 G/A cg18598329 chr3:10140678 FANCD2;C3orf24 -0.89 -12.69 -0.57 2.6e-30 Alzheimer's disease; CRC cis rs6933660 0.646 rs6911456 chr6:151778934 A/G cg10883421 chr6:151773342 RMND1;C6orf211 0.71 11.78 0.54 5.68e-27 Menarche (age at onset); CRC cis rs7412746 0.658 rs7521719 chr1:150913134 G/A cg10589385 chr1:150898437 SETDB1 0.32 6.8 0.35 4.99e-11 Melanoma; CRC cis rs6582630 0.502 rs11514371 chr12:38306306 G/C cg13010199 chr12:38710504 ALG10B 0.46 6.25 0.33 1.3e-9 Drug-induced liver injury (flucloxacillin); CRC cis rs8060686 0.641 rs9932251 chr16:68131732 G/A cg26727032 chr16:67993705 SLC12A4 -0.6 -8.11 -0.41 1.04e-14 HDL cholesterol;Metabolic syndrome; CRC cis rs2952156 0.920 rs2247862 chr17:37829129 A/G cg00129232 chr17:37814104 STARD3 -0.66 -10.96 -0.52 4.75e-24 Asthma; CRC cis rs208520 1.000 rs208527 chr6:66957209 A/C cg07460842 chr6:66804631 NA -0.92 -11.45 -0.53 8.97e-26 Exhaled nitric oxide output; CRC cis rs9527 0.590 rs10883829 chr10:104840635 T/C cg15744005 chr10:104629667 AS3MT -0.29 -5.84 -0.31 1.26e-8 Arsenic metabolism; CRC cis rs2180341 0.618 rs12199451 chr6:127597780 C/G cg24812749 chr6:127587940 RNF146 0.62 9.18 0.45 5.01e-18 Breast cancer; CRC cis rs34526934 0.608 rs34720456 chr2:177027292 G/A cg09355771 chr2:177043147 NA -0.51 -6.49 -0.34 3.14e-10 Obstructive sleep apnea trait (apnea hypopnea index); CRC cis rs3126085 0.935 rs4845429 chr1:152225376 G/C cg09127314 chr1:152161683 NA 0.52 6.8 0.35 5.05e-11 Atopic dermatitis; CRC cis rs524281 0.861 rs6591207 chr11:65949674 A/T cg14036092 chr11:66035641 RAB1B -0.5 -6.06 -0.32 3.69e-9 Electroencephalogram traits; CRC cis rs11123170 0.503 rs28679654 chr2:113967617 C/T cg21482265 chr2:113992762 PAX8;LOC440839;LOC654433 0.52 6.21 0.32 1.57e-9 Renal function-related traits (BUN); CRC cis rs10751667 0.643 rs7395613 chr11:933873 C/T cg06064525 chr11:970664 AP2A2 -0.34 -6.75 -0.35 6.62e-11 Alzheimer's disease (late onset); CRC cis rs7659604 0.517 rs56311153 chr4:122729685 T/C cg06713675 chr4:122721982 EXOSC9 -0.51 -8.24 -0.41 4.19e-15 Type 2 diabetes; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg16263701 chr12:48213605 HDAC7 0.44 6.29 0.33 1e-9 Intelligence (multi-trait analysis); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg26634885 chr17:43209687 PLCD3;ACBD4 0.44 7.24 0.37 3.1e-12 Liver disease severity in Alagille syndrome; CRC cis rs4665809 0.590 rs9309474 chr2:26448830 T/A cg22920501 chr2:26401640 FAM59B -0.83 -11.96 -0.55 1.28e-27 Gut microbiome composition (summer); CRC cis rs17401966 0.558 rs4846218 chr1:10452040 G/T cg19773385 chr1:10388646 KIF1B -0.46 -7.41 -0.38 1.07e-12 Hepatocellular carcinoma; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg25840210 chr13:45152287 NA 0.42 6.16 0.32 2.08e-9 Intelligence (multi-trait analysis); CRC trans rs11148252 0.553 rs9536219 chr13:53227301 C/T cg18335740 chr13:41363409 SLC25A15 0.75 13.33 0.59 1.02e-32 Lewy body disease; CRC trans rs35110281 0.659 rs73367822 chr21:45024252 C/T cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.44 7.13 0.37 6.35e-12 Mean corpuscular volume; CRC cis rs10504229 1.000 rs74546828 chr8:58171678 A/G cg02725872 chr8:58115012 NA -0.38 -6.43 -0.33 4.44e-10 Developmental language disorder (linguistic errors); CRC cis rs4731207 0.596 rs1531715 chr7:124638207 G/A cg23710748 chr7:124431027 NA -0.39 -6.27 -0.33 1.15e-9 Cutaneous malignant melanoma; CRC cis rs11690935 1.000 rs12053003 chr2:172537350 A/C cg13550731 chr2:172543902 DYNC1I2 1.1 19.13 0.73 2.29e-55 Schizophrenia; CRC cis rs1008375 1.000 rs6449319 chr4:17640283 T/A cg16339924 chr4:17578868 LAP3 0.55 7.29 0.37 2.33e-12 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs6951245 1.000 rs11763835 chr7:1094513 A/G cg21664854 chr7:1097933 C7orf50;GPR146 0.77 8.79 0.44 8.25e-17 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs17443541 0.507 rs6709301 chr2:200466505 G/A cg03741458 chr2:200468445 NA -0.36 -5.77 -0.3 1.82e-8 Intelligence (multi-trait analysis); CRC cis rs6912958 0.559 rs242280 chr6:88048714 G/A cg12350822 chr6:88032061 C6orf162;GJB7 0.46 9.25 0.45 2.94e-18 Monocyte percentage of white cells; CRC cis rs11249608 0.548 rs6867208 chr5:178455575 G/A cg01312482 chr5:178451176 ZNF879 -0.35 -5.95 -0.31 6.76e-9 Pubertal anthropometrics; CRC cis rs59918340 0.764 rs4961256 chr8:142229946 G/A cg03316587 chr8:142245164 NA -0.39 -5.9 -0.31 8.92e-9 Immature fraction of reticulocytes; CRC cis rs6089584 0.816 rs744778 chr20:60631365 A/G cg18761221 chr20:60518478 NA 0.48 7.78 0.39 9.17e-14 Body mass index; CRC cis rs13108904 0.539 rs13141169 chr4:1340353 C/T cg24560729 chr4:1342394 KIAA1530 0.39 6.17 0.32 1.99e-9 Obesity-related traits; CRC cis rs832540 0.669 rs832538 chr5:56200016 C/T cg20203395 chr5:56204925 C5orf35 -0.54 -7.55 -0.38 4.3e-13 Coronary artery disease; CRC trans rs1814175 0.765 rs11493326 chr11:50018063 T/C cg15704280 chr7:45808275 SEPT13 -0.96 -18.74 -0.72 7.97e-54 Height; CRC cis rs10946940 1.000 rs10946940 chr6:27560587 A/G cg02683197 chr6:28174875 NA -0.52 -7.3 -0.37 2.14e-12 Systemic lupus erythematosus; CRC cis rs7680126 0.585 rs34768406 chr4:10118350 C/A cg00071950 chr4:10020882 SLC2A9 -0.48 -5.71 -0.3 2.48e-8 Urate levels in lean individuals;Urate levels in overweight individuals;Urate levels in obese individuals; CRC trans rs10983614 1.000 rs7867776 chr9:120072627 A/G cg11149768 chr20:4129361 SMOX 0.49 6.62 0.34 1.44e-10 Survival in pancreatic cancer; CRC cis rs9467773 1.000 rs2393670 chr6:26535541 A/G cg09904177 chr6:26538194 HMGN4 0.86 14.87 0.63 1.3e-38 Intelligence (multi-trait analysis); CRC cis rs9311474 0.508 rs2878628 chr3:52584715 C/T cg18099408 chr3:52552593 STAB1 0.47 7.95 0.4 2.98e-14 Electroencephalogram traits; CRC cis rs7666738 0.830 rs28867388 chr4:98962794 A/T cg17366294 chr4:99064904 C4orf37 0.43 7.36 0.38 1.49e-12 Colonoscopy-negative controls vs population controls; CRC cis rs4862750 0.872 rs6553030 chr4:187899234 T/C cg11301795 chr4:187892539 NA -0.87 -20.32 -0.75 4.87e-60 Lobe attachment (rater-scored or self-reported); CRC cis rs6499129 0.702 rs8044843 chr16:67318242 A/G cg26727032 chr16:67993705 SLC12A4 -0.55 -6.56 -0.34 2.09e-10 Waist-to-hip ratio adjusted for body mass index; CRC cis rs7618915 0.547 rs12486847 chr3:52691112 T/C cg18099408 chr3:52552593 STAB1 -0.44 -7.16 -0.37 5.27e-12 Bipolar disorder; CRC cis rs791888 0.698 rs7893652 chr10:89431060 A/G cg13926569 chr10:89418898 PAPSS2 -0.44 -6.43 -0.33 4.58e-10 Magnesium levels; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg16917537 chr7:73098262 DNAJC30;WBSCR22 0.43 6.05 0.32 3.98e-9 Response to antipsychotic treatment; CRC cis rs7959452 0.532 rs2291005 chr12:69764388 A/G cg20891283 chr12:69753455 YEATS4 0.91 17.38 0.69 1.84e-48 Blood protein levels; CRC cis rs4676482 0.796 rs4676609 chr3:39214256 C/T cg02254461 chr3:39195904 CSRNP1 0.63 8.62 0.43 2.83e-16 Colonoscopy-negative controls vs population controls; CRC cis rs7149337 0.805 rs2999357 chr14:51606001 C/G cg23942311 chr14:51606299 NA 0.83 17.41 0.69 1.41e-48 Cancer; CRC cis rs9399135 0.967 rs7763836 chr6:135362378 T/C cg22676075 chr6:135203613 NA 0.39 6.03 0.32 4.51e-9 Red blood cell count; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg14049615 chr4:87928107 AFF1 0.38 6.05 0.32 4.02e-9 Liver disease severity in Alagille syndrome; CRC cis rs6598955 0.724 rs12732295 chr1:26602251 C/T cg04990556 chr1:26633338 UBXN11 -0.77 -13.03 -0.58 1.39e-31 Obesity-related traits; CRC cis rs9916302 0.904 rs12600751 chr17:37553651 G/C cg15445000 chr17:37608096 MED1 -0.39 -8.18 -0.41 6.36e-15 Glomerular filtration rate (creatinine); CRC cis rs9467711 0.659 rs72845428 chr6:26550144 C/T cg16898833 chr6:26189333 HIST1H4D 1.14 8.46 0.42 8.89e-16 Autism spectrum disorder or schizophrenia; CRC cis rs6564851 0.506 rs7187615 chr16:81254052 G/A cg05274606 chr16:81253692 PKD1L2 -0.35 -5.69 -0.3 2.83e-8 Carotenoid and tocopherol levels; CRC cis rs1005277 0.602 rs2504142 chr10:38383793 C/T cg00409905 chr10:38381863 ZNF37A -0.68 -11.31 -0.53 2.89e-25 Extrinsic epigenetic age acceleration; CRC cis rs9902453 0.904 rs12103671 chr17:28408217 C/T cg26525008 chr17:28256777 EFCAB5;SSH2 -0.7 -11.5 -0.54 6.17e-26 Coffee consumption (cups per day); CRC cis rs5769707 0.568 rs2011097 chr22:50018069 A/G cg20744362 chr22:50050164 C22orf34 0.36 6.57 0.34 1.93e-10 Monocyte count;Monocyte percentage of white cells; CRC cis rs875971 1.000 rs7801282 chr7:65613687 C/T cg00343986 chr7:65444356 GUSB -0.45 -6.66 -0.34 1.12e-10 Aortic root size; CRC cis rs5769765 0.862 rs9616380 chr22:50312225 T/C cg02269571 chr22:50332266 NA -0.61 -7.92 -0.4 3.64e-14 Schizophrenia; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg19071342 chr2:85789035 GGCX 0.42 6.13 0.32 2.54e-9 Intelligence (multi-trait analysis); CRC cis rs1008375 0.966 rs10939736 chr4:17581617 T/A cg02297831 chr4:17616191 MED28 0.44 5.73 0.3 2.27e-8 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs3857067 0.806 rs2171384 chr4:95103545 G/A cg11021082 chr4:95130006 SMARCAD1 -0.49 -7.65 -0.39 2.22e-13 QT interval; CRC cis rs2882667 0.858 rs11948429 chr5:138458584 G/A cg09476006 chr5:138032270 NA 0.45 6.85 0.35 3.59e-11 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs853679 0.517 rs9393891 chr6:28079160 C/T cg03623178 chr6:28175578 NA 0.95 12.17 0.56 2.13e-28 Depression; CRC trans rs2727020 0.658 rs10839269 chr11:49385596 A/G cg03929089 chr4:120376271 NA -0.88 -16.15 -0.66 1.27e-43 Coronary artery disease; CRC cis rs9715521 0.900 rs4860450 chr4:59827819 G/A cg11281224 chr4:60001000 NA -0.39 -5.78 -0.3 1.75e-8 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs12594515 0.967 rs71405295 chr15:45988921 T/C cg22117107 chr15:45993392 NA -0.44 -9.09 -0.45 9.56e-18 Waist circumference;Weight; CRC cis rs4808199 1.000 rs7258508 chr19:19475469 T/C cg03709012 chr19:19516395 GATAD2A 0.88 11.28 0.53 3.64e-25 Nonalcoholic fatty liver disease; CRC trans rs7618501 1.000 rs9872864 chr3:49792023 A/G cg21659725 chr3:3221576 CRBN -0.91 -17.2 -0.69 9.93e-48 Intelligence (multi-trait analysis); CRC cis rs4285028 0.731 rs2332035 chr3:121715432 C/T cg20356878 chr3:121714668 ILDR1 -0.52 -7.7 -0.39 1.66e-13 Multiple sclerosis; CRC cis rs629535 0.773 rs569064 chr8:70065967 A/G cg26132723 chr8:70041827 NA 0.36 5.82 0.31 1.41e-8 Dupuytren's disease; CRC cis rs11105298 0.891 rs12228177 chr12:89862030 G/T cg00757033 chr12:89920650 WDR51B 0.37 6.13 0.32 2.52e-9 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; CRC cis rs6502050 0.835 rs4459614 chr17:80086597 C/T cg09264619 chr17:80180166 NA 0.35 5.88 0.31 1.02e-8 Life satisfaction; CRC cis rs3751196 1.000 rs3751196 chr12:104157502 G/A cg02344784 chr12:104178138 NT5DC3 0.7 7.11 0.37 7.16e-12 Sense of smell; CRC cis rs60843830 1.000 rs58461606 chr2:267367 G/T cg00108164 chr2:264199 ACP1;SH3YL1 0.62 9.81 0.48 4.41e-20 Spherical equivalent (joint analysis main effects and education interaction); CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg23104823 chr14:45553408 PRPF39 -0.54 -6.68 -0.35 1.02e-10 Diisocyanate-induced asthma; CRC cis rs7927771 0.793 rs12803525 chr11:47413475 G/A cg20307385 chr11:47447363 PSMC3 -0.64 -9.27 -0.46 2.55e-18 Subjective well-being; CRC cis rs3751196 1.000 rs74981851 chr12:104176212 C/A cg02344784 chr12:104178138 NT5DC3 0.73 7.73 0.39 1.3e-13 Sense of smell; CRC trans rs867371 0.502 rs28610286 chr15:82525655 C/T cg04831495 chr15:85060580 GOLGA6L5 -0.39 -6.15 -0.32 2.25e-9 Cognitive ability;Cognitive ability (multi-trait analysis); CRC cis rs4888262 0.545 rs7195499 chr16:74693973 C/G cg01733217 chr16:74700730 RFWD3 0.81 12.31 0.56 6.55e-29 Testicular germ cell tumor; CRC cis rs7107174 1.000 rs2512546 chr11:77957276 T/C cg02023728 chr11:77925099 USP35 0.48 8.27 0.41 3.36e-15 Testicular germ cell tumor; CRC cis rs77861329 1.000 rs352150 chr3:52209995 A/G cg08692210 chr3:52188851 WDR51A 0.83 7.8 0.39 8.46e-14 Macrophage inflammatory protein 1b levels; CRC cis rs1865760 0.516 rs9358903 chr6:26061949 A/C cg18357526 chr6:26021779 HIST1H4A 0.43 6.05 0.32 4.01e-9 Height; CRC cis rs9916302 0.861 rs8081033 chr17:37506650 A/G cg00129232 chr17:37814104 STARD3 0.54 7.99 0.4 2.24e-14 Glomerular filtration rate (creatinine); CRC cis rs653465 0.739 rs56259835 chr3:27166202 C/T cg02860705 chr3:27208620 NA -0.39 -6.09 -0.32 3.22e-9 Breast cancer (early onset); CRC cis rs7493 1.000 rs2299264 chr7:95046708 C/T cg01874867 chr7:94954059 PON1 -0.49 -6.35 -0.33 7.25e-10 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs6951245 1.000 rs77868187 chr7:1093968 A/C cg03188948 chr7:1209495 NA 0.66 6.96 0.36 1.9e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs6951245 0.572 rs11559183 chr7:1037025 C/A cg26224354 chr7:1096374 C7orf50;GPR146 -0.93 -7.94 -0.4 3.13e-14 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs13256369 0.901 rs12679831 chr8:8566411 T/G cg06671706 chr8:8559999 CLDN23 0.59 8.38 0.42 1.59e-15 Obesity-related traits; CRC cis rs58688157 0.705 rs11539530 chr11:609353 G/A cg02461776 chr11:598696 PHRF1 0.46 5.82 0.31 1.41e-8 Systemic lupus erythematosus; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg13336335 chr8:42751664 RNF170;HOOK3 0.39 6.04 0.32 4.08e-9 Liver disease severity in Alagille syndrome; CRC cis rs6860806 0.661 rs4705927 chr5:131578608 C/G cg04518342 chr5:131593106 PDLIM4 0.46 8.61 0.43 3.07e-16 Breast cancer; CRC cis rs67311347 0.955 rs2123999 chr3:40378738 C/T cg09455208 chr3:40491958 NA 0.41 8.14 0.41 8.43e-15 Renal cell carcinoma; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg13370280 chr6:137539688 IFNGR1 0.45 6.03 0.32 4.37e-9 Thyroid stimulating hormone; CRC trans rs1656966 1.000 rs1656966 chr3:186466252 C/T cg25163015 chr11:64052221 BAD;GPR137 0.41 6.44 0.33 4.22e-10 Myopia (pathological); CRC cis rs8114671 0.562 rs1018447 chr20:33401707 A/G cg24642439 chr20:33292090 TP53INP2 -0.35 -5.85 -0.31 1.16e-8 Height; CRC cis rs1274963 0.601 rs2063634 chr3:39196452 A/G cg02254461 chr3:39195904 CSRNP1 -0.52 -7.58 -0.39 3.61e-13 Chronic lymphocytic leukemia; CRC cis rs1691799 0.867 rs1168338 chr12:66759369 T/C cg16791601 chr12:66731901 HELB -0.73 -12.88 -0.58 5.19e-31 White blood cell count (basophil); CRC cis rs2033711 0.783 rs11671113 chr19:58958087 C/T cg13877915 chr19:58951672 ZNF132 0.47 7.58 0.39 3.61e-13 Uric acid clearance; CRC cis rs2839186 0.721 rs3788252 chr21:47661235 C/T cg12516959 chr21:47718080 NA -0.33 -5.73 -0.3 2.31e-8 Testicular germ cell tumor; CRC cis rs561341 1.000 rs4795670 chr17:30244839 T/C cg00745463 chr17:30367425 LRRC37B -0.57 -6.93 -0.36 2.28e-11 Hip circumference adjusted for BMI; CRC cis rs970548 0.862 rs10900230 chr10:46130389 C/T cg15590007 chr10:45870220 ALOX5 0.43 5.74 0.3 2.16e-8 Total cholesterol levels;Cholesterol, total;HDL cholesterol;HDL cholesterol levels; CRC cis rs2836974 0.666 rs11910705 chr21:40685604 C/T cg17971929 chr21:40555470 PSMG1 -0.66 -9.61 -0.47 2.03e-19 Cognitive function; CRC cis rs10484885 0.775 rs72919985 chr6:90534641 A/G cg13799429 chr6:90582589 CASP8AP2 -0.72 -7.73 -0.39 1.3e-13 QRS interval (sulfonylurea treatment interaction); CRC cis rs780094 0.544 rs780110 chr2:27685388 G/A cg17158414 chr2:27665306 KRTCAP3 -0.26 -5.72 -0.3 2.42e-8 Calcium levels;Fasting blood insulin;Metabolic traits;Triglyceride levels;Fasting plasma glucose;Urate levels in overweight individuals;Urate levels in obese individuals;Uric acid levels;Height;Age-related diseases, mortality and associated endophenotypes;Renal underexcretion gout;Fasting blood glucose (BMI interaction);Urate levels;Gondoic acid (20:1n-9) levels;Fasting blood insulin (BMI interaction);Triglycerides;Plasma omega-3 polyunsaturated fatty acid levels (docosapentaenoic acid);Type 2 diabetes;Nonalcoholic fatty liver disease;Hypertriglyceridemia;C-reactive protein;Age-related disease endophenotypes;LDL cholesterol;Metabolic syndrome;Crohn's disease;Alcohol consumption (drinks per week);Homeostasis model assessment of insulin resistance;Alcohol consumption;Red blood cell count;Fasting blood glucose; CRC cis rs7552404 0.961 rs1767458 chr1:76219155 A/G cg03433033 chr1:76189801 ACADM 0.74 11.17 0.52 8.95e-25 Blood metabolite levels;Acylcarnitine levels; CRC cis rs9457247 1.000 rs422562 chr6:167406318 A/G cg23791538 chr6:167370224 RNASET2 -0.38 -5.89 -0.31 9.46e-9 Crohn's disease; CRC cis rs12995491 0.763 rs1914735 chr2:88511953 A/T cg07952391 chr2:88470173 THNSL2 -0.42 -6.2 -0.32 1.66e-9 Response to metformin (IC50); CRC cis rs1865760 0.566 rs2858993 chr6:26087856 T/A cg18357526 chr6:26021779 HIST1H4A 0.41 5.76 0.3 1.95e-8 Height; CRC cis rs780096 0.526 rs1647266 chr2:27693485 T/C cg17158414 chr2:27665306 KRTCAP3 -0.3 -6.68 -0.35 9.98e-11 Total body bone mineral density; CRC cis rs1799949 1.000 rs4793194 chr17:41218333 G/A cg23758822 chr17:41437982 NA 0.8 13.57 0.6 1.27e-33 Menopause (age at onset); CRC cis rs10504229 1.000 rs66672857 chr8:58179817 G/C cg02725872 chr8:58115012 NA -0.38 -6.43 -0.33 4.44e-10 Developmental language disorder (linguistic errors); CRC cis rs7849270 1.000 rs7021449 chr9:131899312 T/C cg13538475 chr9:131942899 NA -0.33 -6.35 -0.33 7.18e-10 Blood metabolite ratios; CRC cis rs4555082 0.834 rs2816607 chr14:105718385 A/T cg10792982 chr14:105748885 BRF1 0.35 5.63 0.3 3.81e-8 Mean platelet volume;Platelet distribution width; CRC cis rs17270561 0.609 rs1408271 chr6:25859621 T/A cg17691542 chr6:26056736 HIST1H1C 0.61 8.4 0.42 1.34e-15 Iron status biomarkers; CRC cis rs9916302 0.821 rs12938268 chr17:37572139 G/A cg07936489 chr17:37558343 FBXL20 -0.83 -12.53 -0.57 1.06e-29 Glomerular filtration rate (creatinine); CRC cis rs7178572 0.568 rs28584877 chr15:77599003 C/A cg22256960 chr15:77711686 NA 0.63 8.83 0.44 6.14e-17 Type 2 diabetes; CRC trans rs4698169 0.510 rs675984 chr4:17123821 A/G cg05735659 chr12:48099394 RPAP3 -0.71 -6.27 -0.33 1.11e-9 Temperament (bipolar disorder); CRC cis rs9715521 0.868 rs12650159 chr4:59818550 C/T cg11281224 chr4:60001000 NA -0.4 -5.82 -0.31 1.42e-8 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs1008375 0.932 rs12500912 chr4:17603318 C/T cg16339924 chr4:17578868 LAP3 0.52 6.75 0.35 6.86e-11 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs6942756 0.659 rs624118 chr7:129096653 C/T cg02491457 chr7:128862824 NA -0.6 -8.16 -0.41 7.25e-15 White matter hyperintensity burden; CRC cis rs6963495 0.592 rs114793754 chr7:105152162 G/C cg02135003 chr7:105160482 PUS7 -0.9 -11.7 -0.54 1.09e-26 Bipolar disorder (body mass index interaction); CRC cis rs931127 0.502 rs1466462 chr11:65419364 C/G cg05805236 chr11:65401703 PCNXL3 0.41 6.83 0.35 4.08e-11 Systemic lupus erythematosus; CRC cis rs2153535 0.580 rs9505454 chr6:8478532 T/G cg21535247 chr6:8435926 SLC35B3 0.5 7.54 0.38 4.72e-13 Motion sickness; CRC trans rs7615952 0.932 rs6438948 chr3:125650045 A/T cg07211511 chr3:129823064 LOC729375 1.04 18.28 0.71 5.31e-52 Blood pressure (smoking interaction); CRC cis rs2777491 0.957 rs6493002 chr15:41709195 C/G cg18705301 chr15:41695430 NDUFAF1 -0.73 -12.5 -0.57 1.29e-29 Ulcerative colitis; CRC trans rs1005277 0.579 rs176880 chr10:38401417 C/G cg23533926 chr12:111358616 MYL2 0.51 7.68 0.39 1.84e-13 Extrinsic epigenetic age acceleration; CRC cis rs2797160 0.967 rs2797159 chr6:126009557 G/A cg05901451 chr6:126070800 HEY2 0.4 6.2 0.32 1.65e-9 Endometrial cancer; CRC cis rs763121 0.853 rs5750621 chr22:38956166 C/T cg06022373 chr22:39101656 GTPBP1 0.7 10.23 0.49 1.7e-21 Menopause (age at onset); CRC cis rs7927592 0.763 rs10896327 chr11:68235275 G/C cg01657329 chr11:68192670 LRP5 -0.54 -8.78 -0.44 8.92e-17 Total body bone mineral density; CRC cis rs7202877 0.519 rs4887811 chr16:75307251 C/T cg03315344 chr16:75512273 CHST6 0.47 5.77 0.3 1.86e-8 Type 2 diabetes;Type 1 diabetes; CRC cis rs9372498 0.536 rs9489399 chr6:118767147 C/A cg22561889 chr6:118971681 C6orf204 0.53 6.83 0.35 4.16e-11 Diastolic blood pressure; CRC cis rs4665809 1.000 rs6750681 chr2:26329677 C/T cg22920501 chr2:26401640 FAM59B -0.52 -7.13 -0.37 6.23e-12 Gut microbiome composition (summer); CRC cis rs7772486 0.686 rs857879 chr6:145974043 C/A cg23711669 chr6:146136114 FBXO30 -0.64 -10.5 -0.5 1.98e-22 Lobe attachment (rater-scored or self-reported); CRC cis rs3796352 1.000 rs114562844 chr3:52991584 C/T cg07884673 chr3:53033167 SFMBT1 0.7 6.15 0.32 2.23e-9 Immune reponse to smallpox (secreted IL-2); CRC cis rs3768617 0.510 rs2027076 chr1:183073407 C/A ch.1.3577855R chr1:183094577 LAMC1 0.87 15.46 0.65 6.33e-41 Fuchs's corneal dystrophy; CRC trans rs116095464 0.558 rs10058428 chr5:235608 A/G cg00938859 chr5:1591904 SDHAP3 0.74 7.92 0.4 3.68e-14 Breast cancer; CRC cis rs478304 0.654 rs7115734 chr11:65458964 G/A cg27068330 chr11:65405492 SIPA1 -0.67 -9.92 -0.48 1.81e-20 Acne (severe); CRC cis rs4332037 0.539 rs4470910 chr7:2071723 C/T cg23422044 chr7:1970798 MAD1L1 -0.55 -6.66 -0.34 1.16e-10 Bipolar disorder; CRC cis rs9311676 0.618 rs11130639 chr3:58406004 G/T cg06643156 chr3:58380774 PXK 0.42 6.38 0.33 5.84e-10 Systemic lupus erythematosus; CRC cis rs2019137 0.560 rs11123172 chr2:113984303 C/T cg17445212 chr2:113993313 PAX8;LOC440839;LOC654433 -0.47 -7.31 -0.37 2.04e-12 Lymphocyte counts; CRC cis rs9420 0.961 rs11229131 chr11:57562525 G/A cg23127183 chr11:57508653 C11orf31 -0.52 -7.16 -0.37 5.44e-12 Schizophrenia; CRC cis rs3857536 0.776 rs7765531 chr6:66932886 G/A cg07460842 chr6:66804631 NA -0.42 -5.62 -0.3 4.11e-8 Blood trace element (Cu levels); CRC cis rs7786808 0.778 rs34212455 chr7:158224490 C/T cg01191920 chr7:158217561 PTPRN2 -0.91 -17.21 -0.69 8.65e-48 Obesity-related traits; CRC cis rs55665837 1.000 rs11023224 chr11:14457739 G/A cg19336497 chr11:14380999 RRAS2 -0.39 -6.64 -0.34 1.33e-10 Vitamin D levels; CRC cis rs10752881 1.000 rs6697739 chr1:182983333 A/C ch.1.3577855R chr1:183094577 LAMC1 0.87 15.34 0.65 1.9e-40 Colorectal cancer; CRC cis rs4713118 0.539 rs200967 chr6:27862127 A/G cg15786705 chr6:28176104 NA 0.55 7.52 0.38 5.29e-13 Parkinson's disease; CRC cis rs897984 0.806 rs10782002 chr16:30946506 A/G cg02466173 chr16:30829666 NA 0.65 9.75 0.47 6.65e-20 Dementia with Lewy bodies; CRC cis rs13108904 0.517 rs13134568 chr4:1334289 G/A cg21620606 chr4:1342894 KIAA1530 0.51 8.19 0.41 5.83e-15 Obesity-related traits; CRC cis rs6424115 0.830 rs2501426 chr1:24199364 G/A cg10978503 chr1:24200527 CNR2 0.62 11.34 0.53 2.2e-25 Immature fraction of reticulocytes; CRC cis rs853679 0.545 rs35949109 chr6:28025926 T/C cg06470822 chr6:28175283 NA 0.75 6.71 0.35 8.62e-11 Depression; CRC cis rs3736485 0.808 rs2124875 chr15:51833369 T/A cg08986416 chr15:51914746 DMXL2 -0.49 -7.08 -0.36 8.98e-12 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs4237845 0.967 rs4553410 chr12:58301211 G/A cg00677455 chr12:58241039 CTDSP2 0.51 7.83 0.4 6.82e-14 Intelligence (multi-trait analysis); CRC cis rs3741151 0.773 rs7115055 chr11:73227827 T/C cg17517138 chr11:73019481 ARHGEF17 0.98 8.0 0.4 2.12e-14 GIP levels in response to oral glucose tolerance test (120 minutes); CRC cis rs6500395 1.000 rs9930365 chr16:48682154 A/C cg04672837 chr16:48644449 N4BP1 0.45 6.63 0.34 1.38e-10 Response to tocilizumab in rheumatoid arthritis; CRC trans rs3733585 0.534 rs7375642 chr4:9955236 A/G cg26043149 chr18:55253948 FECH -0.5 -7.78 -0.39 9.21e-14 Cleft plate (environmental tobacco smoke interaction); CRC cis rs10489525 0.583 rs1967711 chr1:115630967 C/T cg01522456 chr1:115632236 TSPAN2 0.63 9.03 0.45 1.47e-17 Autism; CRC cis rs7586879 0.616 rs876186 chr2:25125585 C/T cg04586622 chr2:25135609 ADCY3 -0.55 -10.22 -0.49 1.8e-21 Body mass index; CRC cis rs1511802 0.666 rs62350519 chr4:187119701 G/A cg24794857 chr4:187113578 CYP4V2 0.41 5.97 0.31 6.14e-9 Blood protein levels; CRC cis rs6831352 0.703 rs2602854 chr4:100028651 C/T cg13256891 chr4:100009986 ADH5 0.57 7.9 0.4 4.36e-14 Alcohol dependence; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg19043042 chr14:100705857 YY1 0.43 6.08 0.32 3.31e-9 Response to antipsychotic treatment; CRC cis rs2404602 0.622 rs2003344 chr15:76632301 T/C cg23625390 chr15:77176239 SCAPER -0.7 -10.13 -0.49 3.6e-21 Blood metabolite levels; CRC cis rs8180040 0.620 rs9845728 chr3:47103376 C/T cg10298567 chr3:47292165 KIF9 -0.39 -6.02 -0.32 4.64e-9 Colorectal cancer; CRC cis rs9660992 0.573 rs7368327 chr1:205214792 C/T cg00857998 chr1:205179979 DSTYK 0.43 5.71 0.3 2.57e-8 Mean corpuscular volume;Mean platelet volume; CRC cis rs116095464 0.558 rs7731089 chr5:290422 A/C cg22496380 chr5:211416 CCDC127 -0.89 -10.1 -0.49 4.58e-21 Breast cancer; CRC cis rs2985684 0.846 rs4476096 chr14:50019391 A/C cg04989706 chr14:50066350 PPIL5 -0.56 -8.13 -0.41 9.05e-15 Carotid intima media thickness; CRC cis rs6674970 0.518 rs15740 chr1:151040435 G/A cg04469105 chr1:151031679 CDC42SE1;MLLT11 -0.48 -6.18 -0.32 1.95e-9 Childhood ear infection; CRC cis rs1448094 0.580 rs11615323 chr12:86282171 T/C cg25456477 chr12:86230367 RASSF9 0.38 6.34 0.33 7.41e-10 Major depressive disorder; CRC cis rs4727027 0.737 rs10278971 chr7:148780659 A/T cg23583168 chr7:148888333 NA -0.82 -13.48 -0.6 2.92e-33 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC trans rs6686842 0.897 rs2802565 chr1:41551819 T/A cg19787969 chr8:9763211 NA 0.28 6.05 0.32 3.99e-9 Height; CRC cis rs12594515 1.000 rs8031128 chr15:45988528 C/G cg06207120 chr15:45996521 NA 0.32 7.75 0.39 1.14e-13 Waist circumference;Weight; CRC cis rs28386778 0.897 rs2727290 chr17:61894728 G/T cg25654072 chr17:61904446 PSMC5;FTSJ3 0.72 11.25 0.53 4.67e-25 Prudent dietary pattern; CRC cis rs2243480 1.000 rs1796220 chr7:66062100 C/T cg25985355 chr7:65971099 NA -0.52 -5.97 -0.31 6.08e-9 Diabetic kidney disease; CRC cis rs2408955 0.541 rs11168428 chr12:48547128 A/G cg24011408 chr12:48396354 COL2A1 -0.44 -6.49 -0.34 3.14e-10 Glycated hemoglobin levels; CRC cis rs11148252 0.967 rs11620062 chr13:52994026 T/G cg02158880 chr13:53174818 NA 0.46 7.07 0.36 9.57e-12 Lewy body disease; CRC cis rs3091242 0.933 rs909833 chr1:25754140 C/G cg23205692 chr1:25664452 TMEM50A 0.42 6.12 0.32 2.7e-9 Erythrocyte sedimentation rate; CRC cis rs3749237 0.595 rs6797765 chr3:49423976 A/G cg07636037 chr3:49044803 WDR6 0.54 7.84 0.4 6.25e-14 Resting heart rate; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg12628196 chr7:127672458 SND1;LRRC4 0.26 6.39 0.33 5.59e-10 Liver disease severity in Alagille syndrome; CRC cis rs2243480 1.000 rs160648 chr7:65543384 C/A cg12463550 chr7:65579703 CRCP 0.67 6.35 0.33 6.96e-10 Diabetic kidney disease; CRC cis rs34891900 0.507 rs1008378 chr22:18207251 T/C cg19898043 chr22:18121309 BCL2L13 0.52 7.99 0.4 2.32e-14 Sum neutrophil eosinophil counts; CRC cis rs7927771 0.793 rs12803525 chr11:47413475 G/A cg18512352 chr11:47633146 NA -0.4 -7.8 -0.4 8.02e-14 Subjective well-being; CRC cis rs2730245 1.000 rs2657365 chr7:158722753 A/T cg24397884 chr7:158709396 WDR60 -0.92 -15.96 -0.66 6.99e-43 Height; CRC trans rs6951245 0.554 rs35126802 chr7:1134842 C/T cg13565492 chr6:43139072 SRF -0.83 -10.63 -0.51 6.99e-23 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs11098499 0.691 rs28396837 chr4:120271541 G/A cg09307838 chr4:120376055 NA 0.6 9.3 0.46 1.95e-18 Corneal astigmatism; CRC cis rs7584330 0.518 rs113812061 chr2:238447934 T/C cg08992911 chr2:238395768 MLPH 0.57 5.97 0.31 6.16e-9 Prostate cancer; CRC cis rs7945718 0.781 rs11022505 chr11:12822366 A/G cg25843174 chr11:12811716 TEAD1 -0.45 -8.15 -0.41 7.68e-15 Educational attainment (years of education); CRC cis rs1572438 0.760 rs7766707 chr6:869501 C/T cg21062780 chr6:887772 NA -0.38 -5.98 -0.31 5.78e-9 Aging; CRC cis rs2976388 0.609 rs2376491 chr8:143790934 G/A cg15511327 chr8:143859410 LYNX1 0.4 7.26 0.37 2.78e-12 Urinary tract infection frequency; CRC cis rs72781680 0.716 rs2712079 chr2:24082061 G/A cg08917208 chr2:24149416 ATAD2B 0.57 6.86 0.35 3.48e-11 Lymphocyte counts; CRC cis rs1552244 0.882 rs34706481 chr3:10004123 G/A cg00166722 chr3:10149974 C3orf24 0.61 7.57 0.39 3.71e-13 Alzheimer's disease; CRC trans rs1390943 1.000 rs13253777 chr8:20071770 C/G cg06710349 chr5:139737425 NA -0.44 -6.0 -0.31 5.28e-9 Circulating myeloperoxidase levels (serum); CRC cis rs7258465 0.965 rs10409003 chr19:18543054 C/T cg01065977 chr19:18549689 ISYNA1 -0.42 -6.27 -0.33 1.12e-9 Breast cancer; CRC cis rs11971779 0.648 rs10085708 chr7:139110954 A/C cg23387468 chr7:139079360 LUC7L2 0.41 7.05 0.36 1.04e-11 Diisocyanate-induced asthma; CRC cis rs11105298 0.891 rs11105312 chr12:89920733 C/T cg08166232 chr12:89918718 WDR51B;GALNT4 -0.62 -7.89 -0.4 4.41e-14 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; CRC cis rs68170813 0.559 rs6965001 chr7:106933196 A/G cg02696742 chr7:106810147 HBP1 -0.6 -6.65 -0.34 1.25e-10 Coronary artery disease; CRC cis rs7618501 0.633 rs11130234 chr3:50024758 G/T cg05623727 chr3:50126028 RBM5 0.46 7.69 0.39 1.76e-13 Intelligence (multi-trait analysis); CRC cis rs703842 1.000 rs11172351 chr12:58213485 C/T cg00677455 chr12:58241039 CTDSP2 0.64 8.6 0.43 3.27e-16 Multiple sclerosis; CRC cis rs34172651 0.517 rs8059004 chr16:24837905 G/A cg06028605 chr16:24865363 SLC5A11 0.58 9.67 0.47 1.28e-19 Intelligence (multi-trait analysis); CRC cis rs57221529 0.825 rs72703051 chr5:582997 G/A cg16035780 chr5:759353 NA 0.45 5.68 0.3 2.93e-8 Lung disease severity in cystic fibrosis; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg08806622 chr17:27279525 PHF12 0.4 6.32 0.33 8.45e-10 Liver disease severity in Alagille syndrome; CRC cis rs6840360 0.582 rs11732918 chr4:152319045 C/T cg09659197 chr4:152720779 NA 0.33 6.32 0.33 8.5e-10 Intelligence (multi-trait analysis); CRC cis rs75804782 0.520 rs72987319 chr2:239351143 C/T cg18131467 chr2:239335373 ASB1 -0.73 -6.26 -0.33 1.18e-9 Morning vs. evening chronotype;Chronotype; CRC trans rs10021731 0.692 rs1585448 chr4:115412206 G/T cg25927708 chr2:119603813 EN1 -0.33 -6.01 -0.31 4.92e-9 Optic disc area; CRC cis rs1223397 0.651 rs2496154 chr6:13315031 A/G cg07912922 chr6:13274314 PHACTR1 0.37 5.75 0.3 2.04e-8 Blood pressure; CRC cis rs2839186 0.814 rs13052376 chr21:47707403 G/C cg02776659 chr21:47717406 C21orf57 -0.34 -5.62 -0.3 4.13e-8 Testicular germ cell tumor; CRC trans rs7618501 0.966 rs7372966 chr3:49788969 T/C cg21582582 chr3:182698605 DCUN1D1 -0.56 -8.08 -0.41 1.22e-14 Intelligence (multi-trait analysis); CRC cis rs875971 0.862 rs2088655 chr7:65795711 T/C cg00343986 chr7:65444356 GUSB -0.45 -6.17 -0.32 2.05e-9 Aortic root size; CRC cis rs950169 0.579 rs881983 chr15:84647308 C/T cg24253500 chr15:84953950 NA 0.38 6.11 0.32 2.75e-9 Schizophrenia; CRC cis rs758324 0.947 rs9327622 chr5:131125080 T/A cg06307176 chr5:131281290 NA 0.43 6.38 0.33 6.19e-10 Alzheimer's disease in APOE e4- carriers; CRC cis rs735539 0.914 rs7997065 chr13:21273796 A/G cg04906043 chr13:21280425 IL17D 0.44 6.89 0.36 2.85e-11 Dental caries; CRC cis rs950776 0.518 rs952216 chr15:78819202 C/T cg06917634 chr15:78832804 PSMA4 0.66 10.67 0.51 4.86e-23 Sudden cardiac arrest; CRC cis rs7584330 0.868 rs6760842 chr2:238398165 C/T cg11271282 chr2:238384023 NA -0.47 -6.09 -0.32 3.14e-9 Prostate cancer; CRC cis rs17376456 0.825 rs6877030 chr5:93201841 C/A cg09848695 chr5:92956644 FAM172A;MIR2277 0.71 6.31 0.33 8.84e-10 Diabetic retinopathy; CRC cis rs2294693 0.947 rs9369254 chr6:40989408 T/C cg14769373 chr6:40998127 UNC5CL -0.56 -7.48 -0.38 7.01e-13 Gastric cancer;Non-cardia gastric cancer; CRC cis rs10504229 1.000 rs73609760 chr8:58192170 A/G cg02725872 chr8:58115012 NA -0.39 -6.47 -0.34 3.62e-10 Developmental language disorder (linguistic errors); CRC cis rs912057 0.841 rs1294423 chr6:6743795 C/T cg06612196 chr6:6737390 NA 0.51 8.17 0.41 6.92e-15 Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction); CRC trans rs11039798 0.925 rs7482967 chr11:48613527 T/A cg15704280 chr7:45808275 SEPT13 0.61 6.02 0.31 4.62e-9 Axial length; CRC cis rs1800795 0.553 rs1524099 chr7:22781657 G/A cg05472934 chr7:22766657 IL6 0.54 7.9 0.4 4.32e-14 Cerebrospinal fluid clusterin levels in APOEe4- carriers; CRC cis rs9807989 0.839 rs10206753 chr2:102968362 T/C cg03938978 chr2:103052716 IL18RAP 0.37 5.97 0.31 6.2e-9 Asthma; CRC cis rs3733585 0.699 rs28610447 chr4:9971517 T/C cg00071950 chr4:10020882 SLC2A9 -0.54 -9.55 -0.47 2.99e-19 Cleft plate (environmental tobacco smoke interaction); CRC cis rs9814567 1.000 rs12637751 chr3:134266124 A/G cg06109529 chr3:134205091 CEP63;ANAPC13 0.82 12.06 0.55 5.69e-28 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs7772486 0.686 rs1415744 chr6:146022531 C/T cg13319975 chr6:146136371 FBXO30 -0.44 -6.71 -0.35 8.66e-11 Lobe attachment (rater-scored or self-reported); CRC cis rs9322193 0.923 rs12660304 chr6:150060783 A/G cg00933542 chr6:150070202 PCMT1 0.31 6.56 0.34 2.06e-10 Lung cancer; CRC cis rs12188164 0.931 rs115554641 chr5:443236 C/G cg21972741 chr5:435613 AHRR 0.54 7.38 0.38 1.31e-12 Cystic fibrosis severity; CRC cis rs6831352 0.918 rs13107558 chr4:100050200 C/A cg13256891 chr4:100009986 ADH5 -0.62 -8.35 -0.42 1.91e-15 Alcohol dependence; CRC cis rs2688608 0.620 rs12253408 chr10:75495956 G/T cg23231163 chr10:75533350 FUT11 -0.37 -5.93 -0.31 7.74e-9 Inflammatory bowel disease; CRC cis rs17376456 1.000 rs13181660 chr5:93533658 A/G cg25358565 chr5:93447407 FAM172A 0.95 9.46 0.46 5.94e-19 Diabetic retinopathy; CRC cis rs113835537 0.877 rs77239910 chr11:66329639 G/A cg22134325 chr11:66188745 NPAS4 0.37 6.05 0.32 3.89e-9 Airway imaging phenotypes; CRC cis rs7666738 0.861 rs5014702 chr4:99052102 C/A cg17366294 chr4:99064904 C4orf37 0.44 7.29 0.37 2.34e-12 Colonoscopy-negative controls vs population controls; CRC cis rs897984 0.572 rs4889526 chr16:31030344 C/A cg00531865 chr16:30841666 NA -0.46 -6.44 -0.33 4.32e-10 Dementia with Lewy bodies; CRC cis rs9926296 0.509 rs2159113 chr16:89832083 C/T cg21285383 chr16:89894308 SPIRE2 0.34 5.71 0.3 2.53e-8 Vitiligo; CRC cis rs8103278 0.507 rs8112282 chr19:46265029 C/T cg11657440 chr19:46296263 DMWD 0.7 12.35 0.56 4.62e-29 Coronary artery disease; CRC cis rs9513593 1.000 rs12100212 chr13:99966921 C/T cg21788972 chr13:99853209 UBAC2 0.44 5.72 0.3 2.37e-8 Psoriasis; CRC cis rs7632954 0.632 rs7633250 chr3:8515693 G/A cg03495237 chr3:8533978 NA 0.36 6.6 0.34 1.61e-10 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs28386778 0.897 rs894407 chr17:61901641 T/C cg25654072 chr17:61904446 PSMC5;FTSJ3 0.72 11.25 0.53 4.67e-25 Prudent dietary pattern; CRC cis rs2408955 0.522 rs6580650 chr12:48418556 G/T cg21466736 chr12:48725269 NA 0.48 7.23 0.37 3.42e-12 Glycated hemoglobin levels; CRC cis rs939584 0.825 rs7564711 chr2:639061 T/G cg03610516 chr2:642275 NA 0.42 5.64 0.3 3.67e-8 Body mass index; CRC trans rs11039798 0.588 rs666165 chr11:48457439 C/T cg15704280 chr7:45808275 SEPT13 -0.62 -6.54 -0.34 2.33e-10 Axial length; CRC cis rs6570726 1.000 rs373778 chr6:145873252 C/T cg23711669 chr6:146136114 FBXO30 0.72 12.46 0.57 1.82e-29 Lobe attachment (rater-scored or self-reported); CRC cis rs1707322 0.717 rs28396194 chr1:46213227 C/T cg03146154 chr1:46216737 IPP 0.68 9.85 0.48 3.13e-20 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs7216064 0.906 rs1976052 chr17:65830578 C/T cg12091567 chr17:66097778 LOC651250 -0.7 -7.81 -0.4 7.62e-14 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CRC cis rs11098499 0.644 rs34835603 chr4:120553428 C/T cg09307838 chr4:120376055 NA 0.62 9.42 0.46 8.49e-19 Corneal astigmatism; CRC cis rs8060686 0.545 rs74629553 chr16:68176415 C/A cg26727032 chr16:67993705 SLC12A4 -0.57 -6.1 -0.32 3.03e-9 HDL cholesterol;Metabolic syndrome; CRC cis rs1448094 0.511 rs17345272 chr12:86165334 A/C cg18827107 chr12:86230957 RASSF9 -0.39 -5.99 -0.31 5.37e-9 Major depressive disorder; CRC cis rs1005277 0.579 rs11011461 chr10:38431427 G/A cg25517755 chr10:38738941 LOC399744 -0.43 -6.27 -0.33 1.16e-9 Extrinsic epigenetic age acceleration; CRC cis rs9660180 0.836 rs72634845 chr1:1704899 G/A cg05132306 chr1:1846340 CALML6 -0.45 -6.93 -0.36 2.28e-11 Body mass index; CRC cis rs72634258 0.554 rs4908694 chr1:7850898 C/T cg26816564 chr1:7831052 VAMP3 0.81 9.63 0.47 1.67e-19 Inflammatory bowel disease; CRC cis rs2075371 0.796 rs35440439 chr7:134006094 C/T cg02659138 chr7:134003124 SLC35B4 0.43 7.39 0.38 1.19e-12 Mean platelet volume; CRC cis rs12956009 0.583 rs11663646 chr18:44862895 A/G cg20875182 chr18:44561130 TCEB3B;KATNAL2 -0.39 -5.94 -0.31 7.27e-9 Educational attainment (years of education); CRC cis rs11190604 1.000 rs2495750 chr10:102327708 A/G cg07080220 chr10:102295463 HIF1AN 0.46 5.74 0.3 2.11e-8 Palmitoleic acid (16:1n-7) levels; CRC cis rs7208859 0.623 rs73269923 chr17:29102571 C/T cg13385521 chr17:29058706 SUZ12P 0.74 8.34 0.42 2.11e-15 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs2013441 0.965 rs6587063 chr17:20193940 T/C cg13482628 chr17:19912719 NA -0.4 -6.2 -0.32 1.72e-9 Obesity-related traits; CRC trans rs208520 1.000 rs12209225 chr6:66996443 G/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.91 11.06 0.52 2.21e-24 Exhaled nitric oxide output; CRC cis rs7552404 0.883 rs7513363 chr1:76143443 A/G cg10523679 chr1:76189770 ACADM 0.93 14.14 0.61 8.81e-36 Blood metabolite levels;Acylcarnitine levels; CRC trans rs2243480 1.000 rs60683927 chr7:65394768 T/C cg10756647 chr7:56101905 PSPH 0.73 8.07 0.41 1.36e-14 Diabetic kidney disease; CRC cis rs7647973 0.600 rs35174559 chr3:49287759 T/C cg20833759 chr3:49053208 WDR6;DALRD3 0.38 6.15 0.32 2.29e-9 Menarche (age at onset); CRC cis rs7809950 0.678 rs7803151 chr7:106934246 G/A cg23024343 chr7:107201750 COG5 -0.74 -10.29 -0.49 1.05e-21 Coronary artery disease; CRC cis rs2731664 0.819 rs449351 chr5:176872591 T/C cg23176889 chr5:176863531 GRK6 -0.73 -15.99 -0.66 5.53e-43 Intelligence (multi-trait analysis); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg03236992 chr16:78133292 WWOX 0.42 6.06 0.32 3.68e-9 Response to antipsychotic treatment; CRC cis rs1153858 1.000 rs11858495 chr15:45637662 A/G cg14582100 chr15:45693742 SPATA5L1 -0.32 -6.77 -0.35 6e-11 Homoarginine levels; CRC cis rs1950626 0.615 rs12893486 chr14:101463800 C/A cg02351406 chr14:101447389 SNORD114-20;SNORD114-21 0.97 15.09 0.64 1.74e-39 Pelvic organ prolapse (moderate/severe); CRC cis rs17152411 0.895 rs7900929 chr10:126584999 A/C cg07906193 chr10:126599966 NA 0.58 6.93 0.36 2.16e-11 Height; CRC cis rs16924133 0.655 rs72906792 chr11:33190386 C/A cg05567920 chr11:33183001 CSTF3 -0.78 -6.09 -0.32 3.22e-9 Anger; CRC cis rs4555082 0.756 rs76863138 chr14:105736379 C/T cg18132624 chr14:105716052 BTBD6;BRF1 -0.47 -7.4 -0.38 1.17e-12 Mean platelet volume;Platelet distribution width; CRC cis rs861020 0.677 rs12723578 chr1:210032392 G/A cg09163369 chr1:210001066 C1orf107 -0.58 -7.15 -0.37 5.55e-12 Orofacial clefts; CRC cis rs478304 0.934 rs12801731 chr11:65549606 T/C cg27068330 chr11:65405492 SIPA1 0.46 6.85 0.35 3.59e-11 Acne (severe); CRC trans rs9650657 0.769 rs2116094 chr8:10598822 C/T cg06636001 chr8:8085503 FLJ10661 -0.42 -5.97 -0.31 6.18e-9 Neuroticism; CRC cis rs6500395 1.000 rs11644518 chr16:48616789 A/G cg04672837 chr16:48644449 N4BP1 0.44 6.6 0.34 1.69e-10 Response to tocilizumab in rheumatoid arthritis; CRC cis rs931127 0.719 rs11227259 chr11:65459404 T/C cg27068330 chr11:65405492 SIPA1 -0.42 -5.8 -0.3 1.55e-8 Systemic lupus erythematosus; CRC cis rs6751744 0.513 rs10173538 chr2:160569276 C/T cg08347373 chr2:160653686 CD302 -0.39 -6.42 -0.33 4.82e-10 Dysphagia; CRC cis rs6502050 0.835 rs10163496 chr17:80110867 G/A cg19223190 chr17:80058835 NA 0.4 6.36 0.33 6.88e-10 Life satisfaction; CRC cis rs6740322 0.748 rs1549723 chr2:43460514 C/A cg06169590 chr2:43455088 ZFP36L2;LOC100129726 -0.78 -10.01 -0.48 8.91e-21 Coronary artery disease; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg15823064 chr1:87794194 LMO4 0.39 6.62 0.34 1.45e-10 Liver disease severity in Alagille syndrome; CRC cis rs4237845 0.611 rs2888288 chr12:58329935 G/C cg02175503 chr12:58329896 NA 0.77 12.0 0.55 9.01e-28 Intelligence (multi-trait analysis); CRC cis rs4713118 0.513 rs149950 chr6:28033039 T/G cg20615401 chr6:28092323 ZSCAN16 0.47 6.24 0.33 1.34e-9 Parkinson's disease; CRC cis rs7103648 0.932 rs7104036 chr11:47462140 A/G cg20307385 chr11:47447363 PSMC3 1.0 18.93 0.72 1.43e-54 Diastolic blood pressure;Systolic blood pressure; CRC cis rs6951245 1.000 rs79617366 chr7:1111958 G/C cg20603222 chr7:1096387 C7orf50;GPR146 -0.73 -8.68 -0.43 1.83e-16 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC trans rs3749237 1.000 rs2307021 chr3:49765483 C/G cg21659725 chr3:3221576 CRBN 0.54 7.43 0.38 9.52e-13 Resting heart rate; CRC cis rs35110281 0.720 rs162372 chr21:44928863 C/T cg01579765 chr21:45077557 HSF2BP 0.35 6.66 0.34 1.18e-10 Mean corpuscular volume; CRC cis rs919433 0.679 rs13000656 chr2:198522126 T/C cg10820045 chr2:198174542 NA -0.35 -5.71 -0.3 2.57e-8 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC cis rs6062302 0.545 rs2297430 chr20:62229244 T/C cg09650180 chr20:62225654 GMEB2 -0.5 -6.67 -0.35 1.07e-10 Glioblastoma; CRC cis rs6964587 1.000 rs10225892 chr7:91671020 A/G cg17063962 chr7:91808500 NA 0.83 14.53 0.63 2.8e-37 Breast cancer; CRC cis rs2153535 0.547 rs9502720 chr6:8541362 C/A cg21535247 chr6:8435926 SLC35B3 0.5 7.77 0.39 1.01e-13 Motion sickness; CRC cis rs6570726 0.791 rs436498 chr6:145876347 G/A cg13319975 chr6:146136371 FBXO30 -0.45 -6.59 -0.34 1.74e-10 Lobe attachment (rater-scored or self-reported); CRC trans rs1945213 0.659 rs2086558 chr11:55844453 T/G cg15704280 chr7:45808275 SEPT13 0.55 6.15 0.32 2.25e-9 Acute lymphoblastic leukemia (childhood); CRC cis rs1799949 0.965 rs8176130 chr17:41258043 C/T cg01879757 chr17:41196368 BRCA1 -0.43 -6.59 -0.34 1.75e-10 Menopause (age at onset); CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg05360402 chr5:110848191 STARD4 0.48 6.22 0.32 1.55e-9 Thyroid stimulating hormone; CRC cis rs4713118 0.516 rs7739216 chr6:28079946 G/T cg02631126 chr6:28058918 ZSCAN12L1 0.29 5.88 0.31 1.01e-8 Parkinson's disease; CRC cis rs7264396 0.887 rs736031 chr20:34048625 T/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.39 -6.41 -0.33 5.12e-10 Total cholesterol levels; CRC trans rs3942852 0.868 rs10769315 chr11:48110367 A/G cg15704280 chr7:45808275 SEPT13 -0.55 -6.62 -0.34 1.43e-10 Acute lymphoblastic leukemia (childhood); CRC cis rs9611519 1.000 rs5758264 chr22:41616284 T/G cg03806693 chr22:41940476 POLR3H -0.45 -5.91 -0.31 8.38e-9 Neuroticism; CRC cis rs40363 0.671 rs4786425 chr16:3537650 A/G cg22508957 chr16:3507546 NAT15 -0.81 -8.42 -0.42 1.18e-15 Tuberculosis; CRC cis rs12580194 0.593 rs61957938 chr12:55747266 C/G cg23425280 chr12:56401806 NA 0.47 5.72 0.3 2.44e-8 Cancer; CRC cis rs4332037 0.539 rs11764780 chr7:2020904 G/C cg21155852 chr7:2048760 MAD1L1 -0.53 -7.23 -0.37 3.5e-12 Bipolar disorder; CRC cis rs6502050 0.835 rs8074267 chr17:80158325 A/G cg02741985 chr17:80059408 CCDC57 0.42 6.93 0.36 2.24e-11 Life satisfaction; CRC cis rs1163251 0.837 rs839612 chr1:120247176 T/C cg19096424 chr1:120255104 PHGDH 0.41 5.84 0.31 1.29e-8 Blood metabolite levels; CRC cis rs2948294 0.588 rs4840913 chr8:8116906 A/C cg06636001 chr8:8085503 FLJ10661 0.59 7.92 0.4 3.57e-14 Red cell distribution width; CRC trans rs7613875 0.600 rs7061 chr3:50114515 C/T cg21659725 chr3:3221576 CRBN -0.43 -6.2 -0.32 1.71e-9 Body mass index; CRC cis rs6502050 0.835 rs4789678 chr17:80101078 C/T cg19223190 chr17:80058835 NA 0.4 6.33 0.33 7.89e-10 Life satisfaction; CRC cis rs7647973 0.925 rs4955423 chr3:49220448 G/A cg07690219 chr3:49449608 TCTA;RHOA -0.51 -5.93 -0.31 7.74e-9 Menarche (age at onset); CRC cis rs62244186 0.715 rs11130032 chr3:44704083 G/A cg11003573 chr3:44754125 ZNF502 -0.37 -6.5 -0.34 2.93e-10 Depressive symptoms; CRC trans rs9858542 0.953 rs35115732 chr3:49475155 T/C cg21582582 chr3:182698605 DCUN1D1 -0.51 -6.45 -0.34 4.03e-10 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs4073416 0.707 rs761830 chr14:66212986 G/A cg03016385 chr14:66212404 NA -0.42 -5.77 -0.3 1.8e-8 N-glycan levels; CRC cis rs911119 0.955 rs6048933 chr20:23595637 T/G cg16589663 chr20:23618590 CST3 0.57 7.3 0.37 2.16e-12 Chronic kidney disease; CRC cis rs7224314 1.000 rs6504503 chr17:65386690 A/T cg01507342 chr17:65387096 PITPNC1 -0.61 -8.75 -0.43 1.16e-16 Diisocyanate-induced asthma; CRC cis rs875971 0.660 rs801217 chr7:66010577 C/T cg18876405 chr7:65276391 NA -0.61 -10.95 -0.52 5.43e-24 Aortic root size; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg22995176 chr7:76139470 UPK3B 0.4 6.36 0.33 6.9e-10 Liver disease severity in Alagille syndrome; CRC cis rs10504229 0.911 rs77203035 chr8:58175458 C/A cg02725872 chr8:58115012 NA -0.38 -6.43 -0.33 4.44e-10 Developmental language disorder (linguistic errors); CRC cis rs17666538 0.535 rs7822126 chr8:643810 A/G cg07685180 chr8:600429 NA 0.6 6.54 0.34 2.38e-10 IgG glycosylation; CRC cis rs12134245 0.776 rs12125947 chr1:91990487 T/C cg21854759 chr1:92012499 NA -0.52 -8.63 -0.43 2.61e-16 Breast cancer; CRC trans rs9329221 0.741 rs534523 chr8:9884999 C/G cg16141378 chr3:129829833 LOC729375 0.42 6.39 0.33 5.65e-10 Neuroticism; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg00550498 chr19:12251208 ZNF20 0.4 6.65 0.34 1.24e-10 Liver disease severity in Alagille syndrome; CRC cis rs6502050 0.736 rs12150322 chr17:80061582 T/G cg13198984 chr17:80129470 CCDC57 -0.39 -6.63 -0.34 1.41e-10 Life satisfaction; CRC cis rs1552244 0.810 rs6809572 chr3:10100145 G/A cg02579736 chr3:10068473 FANCD2;CIDECP 1.02 13.77 0.6 2.25e-34 Alzheimer's disease; CRC cis rs7618915 0.547 rs6768697 chr3:52703615 C/T cg05573699 chr3:52720067 GNL3;PBRM1 -0.45 -6.32 -0.33 8.47e-10 Bipolar disorder; CRC cis rs9303401 0.573 rs62081879 chr17:57181524 C/T cg10487724 chr17:56770010 TEX14;RAD51C 0.75 8.83 0.44 6.56e-17 Cognitive test performance; CRC trans rs11098499 0.866 rs12510451 chr4:120289143 C/T cg25214090 chr10:38739885 LOC399744 0.61 9.66 0.47 1.39e-19 Corneal astigmatism; CRC cis rs10504229 0.679 rs16920056 chr8:58106218 C/A cg05313129 chr8:58192883 C8orf71 -0.43 -5.87 -0.31 1.09e-8 Developmental language disorder (linguistic errors); CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg19863210 chr8:142139002 DENND3 0.44 6.35 0.33 6.99e-10 Anxiety disorder; CRC cis rs524281 0.861 rs12049852 chr11:65884702 T/C cg14036092 chr11:66035641 RAB1B -0.47 -5.99 -0.31 5.61e-9 Electroencephalogram traits; CRC cis rs2882667 0.929 rs17207828 chr5:138299835 A/G cg09476006 chr5:138032270 NA 0.44 6.88 0.35 3.04e-11 Age-related hearing impairment (SNP x SNP interaction); CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg03243895 chr9:131314908 SPTAN1 -0.42 -6.02 -0.31 4.6e-9 Myopia (pathological); CRC cis rs709400 0.628 rs7154246 chr14:103876794 G/A cg12935359 chr14:103987150 CKB 0.52 8.34 0.42 2.03e-15 Body mass index; CRC cis rs17345786 0.511 rs12639028 chr3:101346033 G/C cg11279151 chr3:101281821 RG9MTD1 -0.59 -7.98 -0.4 2.46e-14 Colonoscopy-negative controls vs population controls; CRC cis rs79349575 0.783 rs4294857 chr17:46983391 G/A cg00947319 chr17:47005597 UBE2Z -0.34 -5.91 -0.31 8.38e-9 Type 2 diabetes; CRC cis rs7762018 1.000 rs4716380 chr6:170090399 A/G cg19338460 chr6:170058176 WDR27 -0.77 -8.27 -0.41 3.35e-15 Thiazide-induced adverse metabolic effects in hypertensive patients; CRC cis rs2050392 0.792 rs303434 chr10:30714440 G/A cg25182066 chr10:30743637 MAP3K8 -0.41 -5.98 -0.31 5.7e-9 Inflammatory bowel disease; CRC cis rs853679 0.517 rs868987 chr6:28110148 A/G cg21251018 chr6:28226885 NKAPL -0.47 -6.2 -0.32 1.73e-9 Depression; CRC cis rs6860806 0.507 rs2631369 chr5:131705266 G/C cg27615366 chr5:131592974 PDLIM4 -0.34 -6.1 -0.32 2.98e-9 Breast cancer; CRC cis rs7945718 0.935 rs11022501 chr11:12809314 T/C cg25843174 chr11:12811716 TEAD1 0.47 9.03 0.45 1.45e-17 Educational attainment (years of education); CRC cis rs4561483 0.771 rs12924398 chr16:11972948 T/A cg08843971 chr16:11963173 GSPT1 -0.62 -9.41 -0.46 8.91e-19 Testicular germ cell tumor; CRC cis rs796364 1.000 rs281762 chr2:200799201 C/G cg12253985 chr2:200820533 C2orf60;C2orf47 0.59 6.55 0.34 2.19e-10 Schizophrenia; CRC cis rs911119 0.955 rs6036474 chr20:23604414 G/A cg16589663 chr20:23618590 CST3 0.54 7.07 0.36 9.51e-12 Chronic kidney disease; CRC cis rs834811 0.583 rs1121039 chr7:135879442 G/C cg01726295 chr7:135938950 NA 0.38 6.46 0.34 3.87e-10 Post-traumatic stress disorder; CRC cis rs9894429 0.700 rs113915083 chr17:79552696 G/C cg18240062 chr17:79603768 NPLOC4 -0.67 -11.69 -0.54 1.23e-26 Eye color traits; CRC cis rs7917772 0.503 rs11191328 chr10:104305185 C/T cg22532475 chr10:104410764 TRIM8 -0.36 -6.68 -0.35 1.05e-10 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC cis rs11676348 0.805 rs13007219 chr2:218963859 C/A cg04731861 chr2:219085781 ARPC2 0.28 5.89 0.31 9.71e-9 Ulcerative colitis; CRC cis rs6586163 1.000 rs1926195 chr10:90753758 G/A cg03111039 chr10:90751583 FAS;ACTA2 -0.51 -7.37 -0.38 1.39e-12 Chronic lymphocytic leukemia; CRC cis rs7666738 0.830 rs10005173 chr4:98816062 T/C cg17366294 chr4:99064904 C4orf37 0.44 7.08 0.36 8.55e-12 Colonoscopy-negative controls vs population controls; CRC trans rs61101201 0.962 rs10835790 chr11:31610022 C/T cg19425870 chr11:3876808 STIM1 -0.52 -6.03 -0.32 4.4e-9 Optic disc area; CRC cis rs1784581 0.721 rs9365356 chr6:162414789 A/G cg17173639 chr6:162384350 PARK2 0.7 11.58 0.54 3.02e-26 Itch intensity from mosquito bite; CRC cis rs4713118 0.669 rs200997 chr6:27811815 G/A cg02683197 chr6:28174875 NA 0.65 9.06 0.45 1.19e-17 Parkinson's disease; CRC trans rs2797160 0.875 rs12527010 chr6:125991507 A/G cg05039488 chr6:79577232 IRAK1BP1 0.53 7.94 0.4 3.22e-14 Endometrial cancer; CRC cis rs1707322 1.000 rs4660328 chr1:46444831 G/T cg03146154 chr1:46216737 IPP 0.51 7.06 0.36 1.01e-11 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs6694672 0.764 rs877897 chr1:197103975 G/A cg13682187 chr1:196946512 CFHR5 0.46 7.37 0.38 1.38e-12 Asthma; CRC cis rs6840360 0.532 rs4235221 chr4:152511193 C/T cg09659197 chr4:152720779 NA 0.32 5.81 0.31 1.44e-8 Intelligence (multi-trait analysis); CRC cis rs6502050 0.835 rs4789731 chr17:80145904 C/T cg19223190 chr17:80058835 NA 0.38 6.09 0.32 3.15e-9 Life satisfaction; CRC cis rs9467711 0.606 rs13212985 chr6:26609989 G/C cg12315302 chr6:26189340 HIST1H4D 0.99 6.93 0.36 2.22e-11 Autism spectrum disorder or schizophrenia; CRC cis rs12594515 0.967 rs71405295 chr15:45988921 T/C cg06207120 chr15:45996521 NA 0.32 7.75 0.39 1.14e-13 Waist circumference;Weight; CRC cis rs4665809 0.887 rs2384324 chr2:26354239 A/G cg27170947 chr2:26402098 FAM59B -0.45 -5.73 -0.3 2.25e-8 Gut microbiome composition (summer); CRC cis rs4930561 0.765 rs4930564 chr11:67983281 C/T cg16338278 chr11:67432957 ALDH3B2 -0.42 -5.89 -0.31 9.77e-9 Breast cancer in childhood cancer survivors;IgG glycosylation; CRC cis rs10046574 0.908 rs997530 chr7:135054147 T/C cg27474649 chr7:135195673 CNOT4 0.6 5.65 0.3 3.51e-8 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs7615952 0.599 rs6438955 chr3:125730333 C/A cg02807482 chr3:125708958 NA -0.42 -5.73 -0.3 2.32e-8 Blood pressure (smoking interaction); CRC cis rs2197308 0.765 rs10880643 chr12:37926452 C/T cg13010199 chr12:38710504 ALG10B -0.49 -7.17 -0.37 4.87e-12 Morning vs. evening chronotype; CRC cis rs4819052 0.565 rs35776291 chr21:46706142 T/C cg19498844 chr21:46707878 POFUT2;LOC642852 0.65 10.06 0.48 6.44e-21 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs6500602 0.682 rs3761679 chr16:4457907 C/G cg14951292 chr16:4525986 HMOX2;NMRAL1 0.67 8.6 0.43 3.31e-16 Schizophrenia; CRC cis rs8014204 0.967 rs4903266 chr14:75344941 C/G cg06998765 chr14:75389618 RPS6KL1 0.24 5.91 0.31 8.37e-9 Caffeine consumption; CRC cis rs9486719 1.000 rs11153070 chr6:97039720 C/G cg06623918 chr6:96969491 KIAA0776 -0.79 -8.35 -0.42 1.94e-15 Migraine;Coronary artery disease; CRC cis rs1799949 0.896 rs8176098 chr17:41268206 A/C cg05368731 chr17:41323189 NBR1 0.69 10.44 0.5 3.21e-22 Menopause (age at onset); CRC trans rs7615952 0.611 rs2971298 chr3:125602713 G/A cg00769240 chr8:12517080 NA -0.56 -6.07 -0.32 3.43e-9 Blood pressure (smoking interaction); CRC cis rs6502050 0.835 rs4523985 chr17:80154466 C/A cg02741985 chr17:80059408 CCDC57 0.42 6.82 0.35 4.4e-11 Life satisfaction; CRC cis rs1355223 0.583 rs1553757 chr11:34867089 G/A cg11058730 chr11:34937778 PDHX;APIP 0.73 11.79 0.55 5.24e-27 Systemic lupus erythematosus and Systemic sclerosis; CRC trans rs7873102 0.702 rs7028020 chr9:38007747 C/T cg25864757 chr3:47206301 SETD2 -0.4 -6.12 -0.32 2.63e-9 Brain structure; CRC cis rs1707322 0.927 rs11211194 chr1:46282084 C/T cg03146154 chr1:46216737 IPP 0.5 6.95 0.36 1.98e-11 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs9733 0.596 rs2867300 chr1:150666990 C/G cg10589385 chr1:150898437 SETDB1 0.3 6.23 0.32 1.41e-9 Tonsillectomy; CRC cis rs7412746 0.658 rs11589458 chr1:150792616 A/G cg18016565 chr1:150552671 MCL1 0.45 6.36 0.33 6.85e-10 Melanoma; CRC cis rs7474896 0.515 rs662928 chr10:38316216 G/T cg25427524 chr10:38739819 LOC399744 0.6 7.34 0.37 1.73e-12 Obesity (extreme); CRC cis rs28386778 0.863 rs8076760 chr17:61920497 T/C cg06601766 chr17:61851465 DDX42;CCDC47 0.44 5.94 0.31 7.26e-9 Prudent dietary pattern; CRC trans rs7267979 0.844 rs6107027 chr20:25288632 A/G cg17903999 chr18:56338584 MALT1 -0.42 -6.86 -0.35 3.46e-11 Liver enzyme levels (alkaline phosphatase); CRC cis rs7811142 0.830 rs11761426 chr7:99956893 A/T cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.15 16.85 0.68 2.34e-46 Platelet count; CRC cis rs7772486 0.790 rs9403750 chr6:146167762 G/A cg23711669 chr6:146136114 FBXO30 0.68 11.62 0.54 2.13e-26 Lobe attachment (rater-scored or self-reported); CRC cis rs597539 0.652 rs557625 chr11:68634722 G/A cg21963583 chr11:68658836 MRPL21 0.59 10.65 0.51 6e-23 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs9443645 0.803 rs12195716 chr6:79535412 T/C cg05283184 chr6:79620031 NA -0.56 -9.02 -0.45 1.56e-17 Intelligence (multi-trait analysis); CRC cis rs55665837 1.000 rs12287715 chr11:14444575 G/A cg19336497 chr11:14380999 RRAS2 -0.39 -6.61 -0.34 1.58e-10 Vitamin D levels; CRC cis rs9611565 0.592 rs4822044 chr22:41979668 G/C cg03806693 chr22:41940476 POLR3H -1.07 -12.27 -0.56 9.03e-29 Vitiligo; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg16285240 chr10:112327411 SMC3 0.44 6.4 0.33 5.36e-10 Intelligence (multi-trait analysis); CRC cis rs7586879 0.796 rs10187348 chr2:25078415 G/C cg04586622 chr2:25135609 ADCY3 -0.55 -9.27 -0.46 2.48e-18 Body mass index; CRC cis rs2228479 0.702 rs12600151 chr16:89831558 C/T cg06558623 chr16:89946397 TCF25 1.12 10.45 0.5 2.84e-22 Skin colour saturation; CRC cis rs4308124 0.708 rs56693625 chr2:111965155 G/A cg04571233 chr2:111982156 NA -0.55 -8.18 -0.41 6.37e-15 Vitiligo; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg07870854 chr16:791252 NARFL 0.39 6.48 0.34 3.41e-10 Liver disease severity in Alagille syndrome; CRC trans rs7819412 0.745 rs4841498 chr8:10985432 C/T cg06636001 chr8:8085503 FLJ10661 -0.54 -8.01 -0.4 1.95e-14 Triglycerides; CRC cis rs881375 0.967 rs2109896 chr9:123683106 C/T cg14255062 chr9:123606675 PSMD5;LOC253039 0.42 6.15 0.32 2.24e-9 Rheumatoid arthritis; CRC cis rs1005277 0.563 rs2505215 chr10:38481273 A/G cg17219203 chr10:38645113 HSD17B7P2 -0.4 -5.61 -0.3 4.37e-8 Extrinsic epigenetic age acceleration; CRC cis rs9311676 0.609 rs11719450 chr3:58456811 A/G cg06643156 chr3:58380774 PXK -0.44 -6.65 -0.34 1.2e-10 Systemic lupus erythematosus; CRC cis rs634534 0.532 rs12794370 chr11:65770413 G/A cg17985854 chr11:65770987 BANF1;EIF1AD 0.53 9.0 0.44 1.87e-17 Sum eosinophil basophil counts;Eosinophil counts; CRC cis rs9640161 0.789 rs2373751 chr7:150021599 G/C cg12556325 chr7:150026731 C7orf29;LRRC61 -0.48 -6.82 -0.35 4.4e-11 Blood protein levels;Circulating chemerin levels; CRC cis rs6866344 0.697 rs62392833 chr5:178135452 T/A cg03877680 chr5:178157825 ZNF354A 0.81 11.1 0.52 1.63e-24 Neutrophil percentage of white cells; CRC cis rs826838 0.872 rs826878 chr12:39088837 A/T cg13010199 chr12:38710504 ALG10B -0.39 -5.67 -0.3 3.14e-8 Heart rate; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg17643699 chr12:27091484 FGFR1OP2;C12orf11 0.41 6.95 0.36 2.02e-11 Liver disease severity in Alagille syndrome; CRC cis rs4713118 0.662 rs469228 chr6:27970704 A/G cg25164649 chr6:28176230 NA 0.62 8.82 0.44 6.67e-17 Parkinson's disease; CRC trans rs1005277 0.579 rs2472176 chr10:38382921 T/C cg17830980 chr10:43048298 ZNF37B -0.6 -9.93 -0.48 1.67e-20 Extrinsic epigenetic age acceleration; CRC cis rs9837602 0.507 rs793455 chr3:99526135 C/A cg07805332 chr3:99536008 MIR548G;C3orf26 0.54 8.27 0.41 3.43e-15 Breast cancer; CRC cis rs6838801 0.892 rs7656480 chr4:77574194 A/G cg17476223 chr4:77663285 SHROOM3 0.42 5.86 0.31 1.14e-8 Cleft lip with or without cleft palate; CRC cis rs736801 0.808 rs72797306 chr5:131800750 G/C cg14196790 chr5:131705035 SLC22A5 0.35 5.71 0.3 2.56e-8 Breast cancer;Mosquito bite size; CRC cis rs2840044 1.000 rs225304 chr17:33921857 G/T cg05299278 chr17:33885742 SLFN14 0.4 6.08 0.32 3.39e-9 Response to radiotherapy in cancer (late toxicity); CRC cis rs4478858 0.746 rs12136121 chr1:31689743 G/C cg00250761 chr1:31883323 NA 0.31 5.92 0.31 8.29e-9 Alcohol dependence; CRC cis rs12580194 0.593 rs11832308 chr12:55755506 C/A cg19537932 chr12:55886519 OR6C68 -0.67 -8.83 -0.44 6.47e-17 Cancer; CRC cis rs739401 0.967 rs451041 chr11:3060725 C/T cg25174290 chr11:3078921 CARS 0.38 5.82 0.31 1.42e-8 Longevity; CRC cis rs738321 0.762 rs5995543 chr22:38579026 G/A cg25457927 chr22:38595422 NA -0.36 -6.76 -0.35 6.39e-11 Breast cancer; CRC cis rs10504229 1.000 rs949848 chr8:58169125 A/G cg24829409 chr8:58192753 C8orf71 -0.66 -11.17 -0.52 9.26e-25 Developmental language disorder (linguistic errors); CRC cis rs4285028 0.580 rs12496036 chr3:121640362 G/A cg20356878 chr3:121714668 ILDR1 -0.46 -7.45 -0.38 8.45e-13 Multiple sclerosis; CRC cis rs7726839 0.540 rs3749615 chr5:601485 C/T cg16447950 chr5:562315 NA -0.74 -9.79 -0.47 5.09e-20 Obesity-related traits; CRC cis rs12295403 0.964 rs61886869 chr11:18688508 C/T cg07538406 chr11:18686895 NA -0.43 -6.28 -0.33 1.06e-9 Ovarian reserve; CRC cis rs9381040 0.610 rs4140580 chr6:41041742 C/T cg04346459 chr6:41068666 NFYA;LOC221442 -0.4 -5.82 -0.31 1.43e-8 Alzheimer's disease (late onset); CRC cis rs13631 0.928 rs9411308 chr9:140000115 C/T cg15396367 chr9:139972779 UAP1L1 0.45 6.84 0.35 3.91e-11 Cerebrospinal fluid biomarker levels; CRC cis rs780096 0.526 rs780117 chr2:27698343 C/G cg21248554 chr2:27665150 KRTCAP3 -0.33 -7.82 -0.4 7.44e-14 Total body bone mineral density; CRC trans rs8073060 0.505 rs225276 chr17:33973034 T/C cg19694781 chr19:47549865 TMEM160 -1.05 -14.75 -0.63 3.75e-38 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; CRC cis rs1552244 0.554 rs6443275 chr3:10008819 G/A cg08888203 chr3:10149979 C3orf24 0.48 7.47 0.38 7.32e-13 Alzheimer's disease; CRC cis rs4713118 0.614 rs9468209 chr6:27694421 C/T cg21251018 chr6:28226885 NKAPL 0.38 6.14 0.32 2.35e-9 Parkinson's disease; CRC cis rs2032447 0.610 rs189911 chr6:25965942 A/G cg03264133 chr6:25882463 NA -0.55 -7.63 -0.39 2.54e-13 Intelligence (multi-trait analysis); CRC trans rs9858542 0.953 rs67216675 chr3:49493151 G/T cg21659725 chr3:3221576 CRBN -0.65 -8.85 -0.44 5.43e-17 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs1552244 1.000 rs58275763 chr3:10143274 C/T cg02579736 chr3:10068473 FANCD2;CIDECP 1.01 13.58 0.6 1.17e-33 Alzheimer's disease; CRC cis rs11252926 0.545 rs1551508 chr10:555469 A/G cg03684893 chr10:554711 DIP2C -0.46 -8.33 -0.42 2.19e-15 Psychosis in Alzheimer's disease; CRC cis rs7586879 0.929 rs6545808 chr2:25124388 C/A cg04586622 chr2:25135609 ADCY3 -0.42 -6.95 -0.36 1.92e-11 Body mass index; CRC cis rs9894429 0.789 rs7502346 chr17:79603741 T/C cg21984481 chr17:79567631 NPLOC4 -0.57 -10.89 -0.51 8.75e-24 Eye color traits; CRC cis rs7586879 0.520 rs6718511 chr2:25122324 A/G cg22495460 chr2:25135724 ADCY3 -0.87 -17.16 -0.69 1.36e-47 Body mass index; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg13362313 chr19:18794263 CRTC1 0.44 6.16 0.32 2.18e-9 Anxiety disorder; CRC cis rs2625529 0.617 rs7175792 chr15:72431883 C/G cg16672083 chr15:72433130 SENP8 -0.48 -7.27 -0.37 2.62e-12 Red blood cell count; CRC cis rs4926298 1.000 rs10423745 chr19:13176815 T/C cg04657146 chr19:12876947 HOOK2 -0.43 -5.76 -0.3 1.94e-8 Bipolar disorder; CRC cis rs2836974 0.644 rs4818017 chr21:40690561 G/T cg06238570 chr21:40685208 BRWD1 -0.82 -12.95 -0.58 2.81e-31 Cognitive function; CRC cis rs7737355 0.947 rs6884741 chr5:130894613 A/G cg06307176 chr5:131281290 NA 0.46 6.37 0.33 6.36e-10 Life satisfaction; CRC cis rs6951245 1.000 rs75016635 chr7:1094121 G/A cg04025307 chr7:1156635 C7orf50 0.64 6.81 0.35 4.54e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs11098499 0.865 rs11722183 chr4:120280597 A/C cg09307838 chr4:120376055 NA 0.7 10.71 0.51 3.68e-23 Corneal astigmatism; CRC cis rs2032447 0.714 rs199739 chr6:25960509 A/C cg27635394 chr6:26043820 HIST1H2BB 0.4 5.78 0.3 1.75e-8 Intelligence (multi-trait analysis); CRC cis rs16975963 0.644 rs35205379 chr19:38176842 C/T cg15135657 chr19:38346511 NA 0.46 6.38 0.33 5.86e-10 Longevity; CRC cis rs9359856 0.529 rs72915915 chr6:90430593 T/C cg13799429 chr6:90582589 CASP8AP2 -0.73 -7.99 -0.4 2.34e-14 Bipolar disorder; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg26859586 chr10:104953231 NT5C2 -0.4 -6.17 -0.32 1.99e-9 Myopia (pathological); CRC cis rs11148252 0.514 rs1886539 chr13:52726090 C/T cg12458913 chr13:53173898 NA 0.39 5.69 0.3 2.8e-8 Lewy body disease; CRC cis rs11148252 0.595 rs9526968 chr13:53240183 T/C cg02158880 chr13:53174818 NA 0.54 8.56 0.43 4.31e-16 Lewy body disease; CRC cis rs2742417 0.603 rs2742453 chr3:45765858 G/A cg04837898 chr3:45731254 SACM1L -0.48 -7.69 -0.39 1.74e-13 Response to anti-depressant treatment in major depressive disorder; CRC cis rs13118159 0.778 rs12640984 chr4:1338834 G/A cg02018176 chr4:1364513 KIAA1530 0.42 7.04 0.36 1.12e-11 Longevity; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg04810377 chr16:11761964 SNN 0.36 5.98 0.31 5.71e-9 Liver disease severity in Alagille syndrome; CRC cis rs5758511 0.689 rs5758691 chr22:42668504 G/C cg00645731 chr22:42541494 CYP2D7P1 0.63 9.65 0.47 1.44e-19 Birth weight; CRC cis rs1552244 0.554 rs4488814 chr3:10002400 C/T cg16606324 chr3:10149918 C3orf24 -0.48 -7.2 -0.37 4.21e-12 Alzheimer's disease; CRC cis rs1568889 0.838 rs10835304 chr11:28296529 A/G cg06544937 chr11:28130018 METT5D1;KIF18A 0.9 15.18 0.64 8.37e-40 Bipolar disorder; CRC cis rs2235642 0.750 rs1894649 chr16:1657284 C/G cg09065629 chr16:1709722 CRAMP1L 0.36 5.64 0.3 3.69e-8 Coronary artery disease; CRC cis rs79976124 0.876 rs17511913 chr6:66644361 C/T cg07460842 chr6:66804631 NA 0.75 9.35 0.46 1.4e-18 Type 2 diabetes; CRC cis rs853679 0.517 rs9393887 chr6:28059020 G/A cg15845792 chr6:28175446 NA 0.97 12.98 0.58 2.13e-31 Depression; CRC cis rs644799 0.862 rs1150361 chr11:95633805 G/A cg25622487 chr11:95524042 FAM76B;CEP57 0.74 11.26 0.53 4.35e-25 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs2243480 0.901 rs35087093 chr7:65405208 C/T cg18252515 chr7:66147081 NA -1.06 -12.44 -0.57 2.13e-29 Diabetic kidney disease; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg06803689 chr22:29949796 THOC5 0.39 6.32 0.33 8.75e-10 Liver disease severity in Alagille syndrome; CRC cis rs7208859 0.573 rs55661352 chr17:29045628 A/G cg01831904 chr17:28903510 LRRC37B2 -0.62 -6.38 -0.33 6.18e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs7809950 0.817 rs11535285 chr7:107143866 A/G cg23024343 chr7:107201750 COG5 -0.75 -10.25 -0.49 1.45e-21 Coronary artery disease; CRC cis rs898097 0.756 rs56249965 chr17:80806603 C/G cg03160526 chr17:80928410 B3GNTL1 -0.41 -5.83 -0.31 1.3e-8 Breast cancer; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg10190698 chr14:50154770 POLE2 0.46 7.33 0.37 1.77e-12 Liver disease severity in Alagille syndrome; CRC cis rs4713118 0.662 rs149970 chr6:27980220 C/T cg15845792 chr6:28175446 NA 0.82 11.41 0.53 1.29e-25 Parkinson's disease; CRC cis rs1005277 0.522 rs289647 chr10:37968278 A/G cg00409905 chr10:38381863 ZNF37A -0.6 -9.41 -0.46 8.9e-19 Extrinsic epigenetic age acceleration; CRC cis rs939574 0.722 rs72955435 chr2:220087354 A/C cg00496455 chr2:220118770 TUBA4A;TUBA4B 0.87 8.21 0.41 5.17e-15 Platelet distribution width; CRC cis rs4713675 0.584 rs6938056 chr6:33669577 C/T cg14003231 chr6:33640908 ITPR3 0.5 7.97 0.4 2.56e-14 Plateletcrit; CRC cis rs834811 0.797 rs2633365 chr7:135879797 A/G cg01726295 chr7:135938950 NA 0.45 7.75 0.39 1.19e-13 Post-traumatic stress disorder; CRC cis rs4666002 0.789 rs6727388 chr2:27932587 A/G cg27432699 chr2:27873401 GPN1 0.55 6.75 0.35 6.62e-11 Phospholipid levels (plasma); CRC trans rs10411161 0.702 rs7256926 chr19:52391988 A/G cg22319618 chr22:45562946 NUP50 -0.58 -6.01 -0.31 4.92e-9 Breast cancer; CRC cis rs7772486 0.686 rs1292336 chr6:145967818 T/C cg13319975 chr6:146136371 FBXO30 0.41 6.1 0.32 2.94e-9 Lobe attachment (rater-scored or self-reported); CRC trans rs11581859 0.950 rs72730329 chr1:99395390 T/A cg12183875 chr3:169587454 LRRC31 0.28 6.34 0.33 7.78e-10 Response to cognitive-behavioural therapy in anxiety disorder; CRC cis rs798554 0.759 rs798495 chr7:2797267 T/C cg17321639 chr7:2759063 NA -0.53 -7.05 -0.36 1.06e-11 Height; CRC cis rs908922 0.523 rs4845786 chr1:152510144 A/G cg23254163 chr1:152506842 NA 0.46 8.89 0.44 4.15e-17 Hair morphology; CRC cis rs7809950 1.000 rs2520264 chr7:107179344 T/C cg23024343 chr7:107201750 COG5 -0.61 -8.75 -0.43 1.15e-16 Coronary artery disease; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg22950391 chr6:28109938 ZNF192 0.45 6.48 0.34 3.44e-10 Response to antipsychotic treatment; CRC cis rs2836974 0.966 rs2836977 chr21:40666066 T/C cg17971929 chr21:40555470 PSMG1 0.81 11.52 0.54 4.9e-26 Cognitive function; CRC cis rs2836974 0.623 rs7280326 chr21:40700408 A/G cg17971929 chr21:40555470 PSMG1 -0.63 -9.03 -0.45 1.45e-17 Cognitive function; CRC cis rs7727544 0.904 rs7736102 chr5:131604257 G/A cg18301423 chr5:131593218 PDLIM4 0.3 5.76 0.3 1.91e-8 Blood metabolite levels; CRC cis rs9300255 0.722 rs67624109 chr12:123824635 C/T cg00376283 chr12:123451042 ABCB9 -0.53 -6.34 -0.33 7.4e-10 Neutrophil percentage of white cells; CRC cis rs17826219 0.568 rs11658027 chr17:29094882 A/G cg01831904 chr17:28903510 LRRC37B2 0.6 6.09 0.32 3.23e-9 Body mass index; CRC trans rs2243480 1.000 rs778704 chr7:65863467 T/C cg10756647 chr7:56101905 PSPH 0.78 8.01 0.4 1.97e-14 Diabetic kidney disease; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg01517273 chr1:154599968 ADAR 0.47 6.01 0.31 4.93e-9 Thyroid stimulating hormone; CRC cis rs9303280 0.806 rs34189114 chr17:38032460 C/T cg20243544 chr17:37824526 PNMT 0.37 5.64 0.3 3.58e-8 Self-reported allergy; CRC cis rs769267 0.929 rs2905431 chr19:19482882 G/A cg01262667 chr19:19385393 TM6SF2 -0.38 -6.33 -0.33 7.89e-10 Tonsillectomy; CRC cis rs10489525 0.583 rs12034918 chr1:115626285 C/T cg01522456 chr1:115632236 TSPAN2 0.49 6.94 0.36 2.11e-11 Autism; CRC cis rs2302190 0.882 rs7213415 chr17:56672433 C/G cg25885038 chr17:56607967 SEPT4 -0.51 -7.7 -0.39 1.63e-13 Vitamin D levels; CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg08467595 chr3:13009117 IQSEC1 0.36 6.09 0.32 3.16e-9 Obesity-related traits; CRC cis rs1552244 0.872 rs6803517 chr3:10065426 C/T cg16606324 chr3:10149918 C3orf24 0.69 9.43 0.46 7.91e-19 Alzheimer's disease; CRC cis rs11190604 1.000 rs10883496 chr10:102221931 T/C cg07570687 chr10:102243282 WNT8B 0.44 5.66 0.3 3.36e-8 Palmitoleic acid (16:1n-7) levels; CRC cis rs7666738 0.830 rs7696686 chr4:98938445 T/C cg17366294 chr4:99064904 C4orf37 0.43 7.32 0.37 1.95e-12 Colonoscopy-negative controls vs population controls; CRC cis rs2153535 0.525 rs1335644 chr6:8488041 A/G cg07606381 chr6:8435919 SLC35B3 0.67 10.78 0.51 2.07e-23 Motion sickness; CRC cis rs79839061 0.610 rs12651368 chr4:856787 G/A cg14530993 chr4:882597 GAK 0.82 7.77 0.39 1.04e-13 Intelligence (multi-trait analysis); CRC trans rs11654801 0.853 rs11658389 chr17:20880718 G/A cg23759823 chr7:139672531 TBXAS1 -0.41 -5.98 -0.31 5.96e-9 Mosquito bite size; CRC cis rs990171 0.874 rs6419573 chr2:103027103 T/C cg03938978 chr2:103052716 IL18RAP 0.46 5.73 0.3 2.23e-8 Lymphocyte counts; CRC trans rs67073037 0.869 rs11677485 chr2:29146094 T/C cg13899017 chr1:159158444 CADM3 -0.35 -5.99 -0.31 5.39e-9 Breast cancer;Breast cancer (estrogen-receptor negative); CRC cis rs2836754 1.000 rs2836753 chr21:40291187 A/G cg20434300 chr21:40194735 ETS2 -0.35 -6.05 -0.32 3.89e-9 Crohn's disease;Body mass index; CRC cis rs2180341 0.960 rs9375503 chr6:127677071 T/C cg24812749 chr6:127587940 RNF146 0.95 13.32 0.59 1.16e-32 Breast cancer; CRC cis rs4665809 0.590 rs1368902 chr2:26440576 T/C cg27170947 chr2:26402098 FAM59B -0.59 -7.71 -0.39 1.53e-13 Gut microbiome composition (summer); CRC cis rs41271951 0.512 rs12074309 chr1:151087827 T/C cg11822372 chr1:151115635 SEMA6C -0.72 -5.83 -0.31 1.35e-8 Blood protein levels; CRC cis rs8060686 0.844 rs7196076 chr16:67887494 T/A cg26727032 chr16:67993705 SLC12A4 -0.56 -6.48 -0.34 3.35e-10 HDL cholesterol;Metabolic syndrome; CRC cis rs9916302 0.706 rs7503081 chr17:37482673 A/G cg15445000 chr17:37608096 MED1 -0.34 -6.04 -0.32 4.2e-9 Glomerular filtration rate (creatinine); CRC cis rs653465 0.739 rs7641830 chr3:27208003 G/A cg02860705 chr3:27208620 NA 0.39 6.03 0.32 4.49e-9 Breast cancer (early onset); CRC cis rs3126085 0.825 rs10788830 chr1:152206898 A/C cg09127314 chr1:152161683 NA 0.49 6.28 0.33 1.07e-9 Atopic dermatitis; CRC cis rs7762018 0.607 rs75964125 chr6:170054290 T/A cg24289452 chr6:170231220 NA -0.73 -6.46 -0.34 3.79e-10 Thiazide-induced adverse metabolic effects in hypertensive patients; CRC cis rs356992 0.915 rs168562 chr2:60747192 T/C cg08426369 chr2:60753602 BCL11A 0.53 7.34 0.38 1.71e-12 Educational attainment (years of education); CRC cis rs2738048 0.545 rs2978950 chr8:6825284 C/G cg24860332 chr8:6827800 DEFA10P -0.47 -6.69 -0.35 9.47e-11 IgA nephropathy; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg20313298 chr4:708468 PCGF3 -0.38 -5.97 -0.31 6.27e-9 Liver disease severity in Alagille syndrome; CRC cis rs7756236 0.521 rs9394368 chr6:36630525 C/G cg08179530 chr6:36648295 CDKN1A -0.56 -8.16 -0.41 7.38e-15 QRS duration; CRC cis rs2179367 0.887 rs506268 chr6:149685617 C/T cg11245181 chr6:149772854 ZC3H12D -0.4 -6.27 -0.33 1.16e-9 Dupuytren's disease; CRC cis rs9486715 0.867 rs9386500 chr6:96889845 A/C cg18709589 chr6:96969512 KIAA0776 0.47 6.91 0.36 2.54e-11 Headache; CRC cis rs17270561 0.609 rs1892246 chr6:25764408 C/T cg17691542 chr6:26056736 HIST1H1C 0.65 8.3 0.42 2.78e-15 Iron status biomarkers; CRC cis rs4969178 0.622 rs11657987 chr17:76387363 G/T cg05887092 chr17:76393375 PGS1 0.63 12.42 0.56 2.67e-29 HDL cholesterol levels; CRC cis rs9303401 0.659 rs62083525 chr17:56658088 A/G cg10487724 chr17:56770010 TEX14;RAD51C 0.79 9.55 0.47 3.04e-19 Cognitive test performance; CRC cis rs747650 0.504 rs11600292 chr11:46958698 A/G cg19486271 chr11:47235900 DDB2 0.44 6.06 0.32 3.74e-9 Acne (severe); CRC cis rs11764590 0.715 rs9639202 chr7:2087315 G/A cg25834613 chr7:1915315 MAD1L1 -0.43 -5.98 -0.31 5.85e-9 Neuroticism; CRC cis rs3785574 0.962 rs2584614 chr17:61929445 C/T cg22520471 chr17:61851767 DDX42;CCDC47 0.43 5.88 0.31 9.99e-9 Height; CRC cis rs4654899 1.000 rs4654902 chr1:21435056 T/G cg02927042 chr1:21476669 EIF4G3 -0.51 -8.12 -0.41 9.48e-15 Superior frontal gyrus grey matter volume; CRC cis rs9733 0.596 rs11803569 chr1:150664077 C/T cg10589385 chr1:150898437 SETDB1 0.28 5.98 0.31 5.86e-9 Tonsillectomy; CRC cis rs13191362 1.000 rs13195226 chr6:163006421 A/G cg21926612 chr6:163149169 PACRG;PARK2 0.76 11.15 0.52 1.03e-24 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs7762018 1.000 rs7762018 chr6:170113244 G/T cg19338460 chr6:170058176 WDR27 -0.59 -6.71 -0.35 8.32e-11 Thiazide-induced adverse metabolic effects in hypertensive patients; CRC cis rs9660180 0.967 rs10907191 chr1:1774820 A/T cg05132306 chr1:1846340 CALML6 -0.5 -7.55 -0.38 4.26e-13 Body mass index; CRC cis rs6502050 0.835 rs8075086 chr17:80092649 A/G cg11859384 chr17:80120422 CCDC57 -0.38 -5.98 -0.31 5.84e-9 Life satisfaction; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg21678189 chr6:10838625 NA 0.41 6.52 0.34 2.68e-10 Liver disease severity in Alagille syndrome; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg03591917 chr3:197476477 FYTTD1;KIAA0226 0.46 5.96 0.31 6.51e-9 Thyroid stimulating hormone; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg27150186 chr21:26979856 MRPL39 0.39 6.11 0.32 2.78e-9 Liver disease severity in Alagille syndrome; CRC cis rs7412746 0.658 rs897815 chr1:150879101 C/T cg17724175 chr1:150552817 MCL1 -0.42 -6.41 -0.33 5.17e-10 Melanoma; CRC cis rs9911578 0.967 rs2567892 chr17:56668929 T/C cg05425664 chr17:57184151 TRIM37 -0.52 -8.21 -0.41 5.21e-15 Intelligence (multi-trait analysis); CRC cis rs7605827 0.930 rs1528622 chr2:15557535 A/T cg19274914 chr2:15703543 NA 0.37 5.68 0.3 2.89e-8 Educational attainment (years of education); CRC cis rs9435341 0.896 rs1730851 chr1:107596443 A/G cg11070056 chr1:107600091 PRMT6 -0.39 -5.64 -0.3 3.75e-8 Facial morphology (factor 21, depth of nasal alae); CRC cis rs1005224 0.889 rs2059382 chr14:76158916 T/C cg04684003 chr14:76127793 TTLL5;C14orf1 -0.47 -6.66 -0.34 1.17e-10 Large artery stroke; CRC cis rs11031096 0.782 rs4910889 chr11:4153231 T/C cg18678763 chr11:4115507 RRM1 -0.41 -7.11 -0.36 7.24e-12 Mean corpuscular volume;Mean corpuscular hemoglobin; CRC cis rs2625529 0.689 rs12161990 chr15:72202440 T/C cg16672083 chr15:72433130 SENP8 0.45 6.47 0.34 3.47e-10 Red blood cell count; CRC cis rs2692947 0.770 rs58730124 chr2:96413338 T/C cg23100626 chr2:96804247 ASTL 0.26 6.87 0.35 3.22e-11 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; CRC trans rs1728785 0.901 rs1170438 chr16:68608256 T/C cg04657470 chr2:198365150 HSPE1;HSPD1 0.59 6.98 0.36 1.59e-11 Ulcerative colitis; CRC cis rs7584330 0.704 rs72620821 chr2:238362615 C/A cg14458575 chr2:238380390 NA 0.9 16.44 0.67 9.63e-45 Prostate cancer; CRC cis rs17067123 0.614 rs55983301 chr4:180070495 A/G cg26610307 chr4:180072759 NA -0.56 -6.72 -0.35 7.84e-11 Response to hepatitis C treatment; CRC cis rs9341808 0.718 rs9448899 chr6:80845864 G/A cg08355045 chr6:80787529 NA 0.42 6.84 0.35 3.92e-11 Sitting height ratio; CRC cis rs611744 0.560 rs58605513 chr8:109279122 A/C cg21045802 chr8:109455806 TTC35 0.44 7.03 0.36 1.18e-11 Dupuytren's disease; CRC cis rs12142240 0.698 rs10158572 chr1:46822440 G/T cg14993813 chr1:46806288 NSUN4 -0.49 -6.22 -0.32 1.55e-9 Menopause (age at onset); CRC cis rs6540559 0.673 rs6694552 chr1:209976459 A/C cg21951975 chr1:209979733 IRF6 0.49 6.6 0.34 1.64e-10 Cleft lip with or without cleft palate; CRC cis rs2658782 0.756 rs2658777 chr11:93148423 C/T cg15737290 chr11:93063684 CCDC67 0.49 7.11 0.37 7.1e-12 Pulmonary function decline; CRC cis rs6952808 0.609 rs10230383 chr7:1950113 T/C cg04267008 chr7:1944627 MAD1L1 -0.62 -9.63 -0.47 1.69e-19 Bipolar disorder and schizophrenia; CRC cis rs875971 0.540 rs35510581 chr7:65578777 G/A cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.39 -5.62 -0.3 4.06e-8 Aortic root size; CRC cis rs7927592 0.956 rs11228258 chr11:68254328 A/C cg01657329 chr11:68192670 LRP5 0.46 6.78 0.35 5.46e-11 Total body bone mineral density; CRC cis rs4237845 0.551 rs116263297 chr12:58273445 A/C cg00677455 chr12:58241039 CTDSP2 0.78 11.27 0.53 3.88e-25 Intelligence (multi-trait analysis); CRC cis rs6963495 0.818 rs73190158 chr7:105153943 T/C cg02135003 chr7:105160482 PUS7 -0.9 -12.2 -0.56 1.71e-28 Bipolar disorder (body mass index interaction); CRC trans rs9650657 0.513 rs7005884 chr8:10796472 A/G cg06636001 chr8:8085503 FLJ10661 -0.61 -9.51 -0.46 4.32e-19 Neuroticism; CRC cis rs78456975 0.546 rs72776254 chr2:1527881 C/T cg01028140 chr2:1542097 TPO -0.57 -5.78 -0.3 1.72e-8 Placebo response in major depressive disorder (% change in symptom score); CRC cis rs17376456 0.877 rs10476601 chr5:93402522 G/A cg21475434 chr5:93447410 FAM172A 0.74 7.56 0.38 4.17e-13 Diabetic retinopathy; CRC cis rs4713118 0.513 rs149941 chr6:28001033 T/C cg21251018 chr6:28226885 NKAPL 0.48 7.54 0.38 4.73e-13 Parkinson's disease; CRC cis rs10504229 0.683 rs16921810 chr8:58106067 A/G cg21724239 chr8:58056113 NA 0.52 6.99 0.36 1.58e-11 Developmental language disorder (linguistic errors); CRC cis rs1552244 1.000 rs9834980 chr3:10065528 G/A cg02579736 chr3:10068473 FANCD2;CIDECP 0.95 12.63 0.57 4.38e-30 Alzheimer's disease; CRC cis rs6460942 0.915 rs80345607 chr7:12442249 T/C cg06484146 chr7:12443880 VWDE -0.81 -8.56 -0.43 4.49e-16 Coronary artery disease; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg24447660 chr3:127872092 EEFSEC 0.51 6.62 0.34 1.48e-10 Anxiety disorder; CRC trans rs7615952 0.800 rs13086460 chr3:125646417 C/T cg02560186 chr11:3602584 NA -0.47 -6.3 -0.33 9.33e-10 Blood pressure (smoking interaction); CRC cis rs9611565 0.512 rs5758450 chr22:42141640 G/A cg03806693 chr22:41940476 POLR3H 1.08 13.48 0.6 2.85e-33 Vitiligo; CRC cis rs1448094 0.534 rs11613070 chr12:86167544 T/A cg19622623 chr12:86230825 RASSF9 -0.37 -5.64 -0.3 3.62e-8 Major depressive disorder; CRC cis rs2072499 1.000 rs2253809 chr1:156172125 T/C cg25208724 chr1:156163844 SLC25A44 1.08 26.29 0.82 7.78e-83 Testicular germ cell tumor; CRC cis rs11190604 0.943 rs11190581 chr10:102243387 T/G cg07080220 chr10:102295463 HIF1AN 0.49 5.89 0.31 9.58e-9 Palmitoleic acid (16:1n-7) levels; CRC cis rs896854 0.715 rs12548874 chr8:95935164 A/C cg09323728 chr8:95962352 TP53INP1 0.42 6.66 0.34 1.14e-10 Type 2 diabetes; CRC cis rs9807841 0.592 rs2043304 chr19:10772112 T/C cg17710535 chr19:10819994 QTRT1 0.43 6.0 0.31 5.19e-9 Inflammatory skin disease; CRC trans rs11039798 0.623 rs594615 chr11:48402804 T/C cg15704280 chr7:45808275 SEPT13 -0.66 -6.94 -0.36 2.15e-11 Axial length; CRC cis rs10193935 1.000 rs13391906 chr2:42538617 C/G cg27598129 chr2:42591480 NA -0.71 -8.16 -0.41 7.39e-15 Colonoscopy-negative controls vs population controls; CRC cis rs4700695 0.841 rs251612 chr5:65275023 G/A cg21114390 chr5:65439923 SFRS12 0.63 6.59 0.34 1.73e-10 Facial morphology (factor 19); CRC cis rs7586879 0.929 rs6545807 chr2:25124358 C/T cg04586622 chr2:25135609 ADCY3 -0.42 -6.95 -0.36 1.92e-11 Body mass index; CRC cis rs1005277 0.579 rs2505241 chr10:38442421 T/C cg25517755 chr10:38738941 LOC399744 -0.42 -6.09 -0.32 3.11e-9 Extrinsic epigenetic age acceleration; CRC cis rs875971 0.522 rs1968127 chr7:66056803 C/T cg00343986 chr7:65444356 GUSB -0.5 -7.51 -0.38 5.55e-13 Aortic root size; CRC cis rs67311347 0.824 rs73073561 chr3:40357298 G/T cg09455208 chr3:40491958 NA 0.35 6.79 0.35 5.15e-11 Renal cell carcinoma; CRC trans rs2270927 0.510 rs31244 chr5:75594743 G/A cg13563193 chr19:33072644 PDCD5 0.71 6.15 0.32 2.28e-9 Mean corpuscular volume; CRC cis rs11711311 1.000 rs921741 chr3:113444051 A/C cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.51 -6.98 -0.36 1.64e-11 IgG glycosylation; CRC cis rs4819052 0.851 rs2838866 chr21:46713014 G/C cg11663144 chr21:46675770 NA -0.74 -11.86 -0.55 2.97e-27 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs3858526 0.834 rs7939099 chr11:5995792 G/A cg05234568 chr11:5960015 NA -0.47 -5.99 -0.31 5.61e-9 DNA methylation (variation); CRC cis rs6860806 0.507 rs635620 chr5:131720263 A/G cg09877947 chr5:131593287 PDLIM4 -0.44 -7.27 -0.37 2.67e-12 Breast cancer; CRC cis rs55882075 0.634 rs11249657 chr5:179111637 G/C cg14593053 chr5:179126677 CANX 0.47 6.88 0.35 3.09e-11 Monocyte percentage of white cells; CRC cis rs1577917 0.839 rs6929514 chr6:86525768 A/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.44 -5.88 -0.31 1e-8 Response to antipsychotic treatment; CRC cis rs4319547 0.585 rs10846792 chr12:122882374 T/C cg05707623 chr12:122985044 ZCCHC8 -0.74 -9.09 -0.45 9.65e-18 Body mass index; CRC cis rs6499255 0.951 rs16959025 chr16:69695589 G/T cg04110750 chr16:69646130 NFAT5 0.45 5.9 0.31 9e-9 IgE levels; CRC cis rs7618915 0.547 rs3755806 chr3:52643685 C/T cg05573699 chr3:52720067 GNL3;PBRM1 0.45 6.51 0.34 2.74e-10 Bipolar disorder; CRC cis rs8014671 0.597 rs1044527 chr14:70833819 C/G cg23702412 chr14:70655803 SLC8A3 -0.29 -5.6 -0.3 4.47e-8 Prostate cancer; CRC cis rs4684776 0.676 rs11714563 chr3:11313214 A/G cg00170343 chr3:11313890 ATG7 -0.51 -5.91 -0.31 8.53e-9 Small vessel stroke; CRC cis rs11690935 0.959 rs2292815 chr2:172586651 C/G cg13550731 chr2:172543902 DYNC1I2 -1.07 -17.36 -0.69 2.22e-48 Schizophrenia; CRC trans rs2303319 0.504 rs1449641 chr2:162619567 T/C cg22902534 chr3:183892754 AP2M1 -0.7 -6.07 -0.32 3.56e-9 Cognitive function; CRC cis rs7727544 0.661 rs273900 chr5:131694606 G/A cg22638593 chr5:131593259 PDLIM4 0.31 5.72 0.3 2.38e-8 Blood metabolite levels; CRC cis rs6860806 0.531 rs272887 chr5:131665713 A/G cg27615366 chr5:131592974 PDLIM4 0.32 5.66 0.3 3.26e-8 Breast cancer; CRC cis rs2404602 0.684 rs965818 chr15:76866785 T/C cg23625390 chr15:77176239 SCAPER -0.9 -15.44 -0.65 7.62e-41 Blood metabolite levels; CRC cis rs7312933 0.558 rs61926593 chr12:42818912 C/T cg19980929 chr12:42632907 YAF2 0.42 6.37 0.33 6.19e-10 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CRC cis rs12134245 0.776 rs13447526 chr1:91983174 A/G cg02896835 chr1:92012615 NA 0.57 9.22 0.45 3.67e-18 Breast cancer; CRC cis rs12413816 0.963 rs12359348 chr10:13765950 C/T cg16485048 chr10:13749193 FRMD4A -0.51 -8.08 -0.41 1.26e-14 Red cell distribution width; CRC cis rs4819052 0.788 rs2236449 chr21:46702506 C/T cg11663144 chr21:46675770 NA -0.69 -10.58 -0.5 1.04e-22 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs28386778 0.897 rs2854214 chr17:61945449 C/G cg25654072 chr17:61904446 PSMC5;FTSJ3 -0.71 -11.04 -0.52 2.52e-24 Prudent dietary pattern; CRC cis rs4662945 0.603 rs1453147 chr2:130271510 A/C cg05903289 chr2:130345205 NA -0.39 -7.6 -0.39 3.15e-13 Response to cytidine analogues (gemcitabine); CRC cis rs9921222 0.500 rs11645742 chr16:367516 C/T cg26944245 chr16:421049 TMEM8A;MRPL28 0.43 5.68 0.3 2.92e-8 Bone mineral density (spine);Bone mineral density; CRC cis rs12900413 0.687 rs12902809 chr15:90305617 C/G cg24249390 chr15:90295951 MESP1 -0.55 -8.75 -0.43 1.17e-16 Coronary artery aneurysm in Kawasaki disease; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg22336747 chr1:161087401 PFDN2;NIT1 0.43 6.35 0.33 7.08e-10 Response to antipsychotic treatment; CRC cis rs9463078 0.605 rs1578676 chr6:44906861 G/A cg25276700 chr6:44698697 NA 0.25 6.1 0.32 3.04e-9 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; CRC cis rs6500602 0.855 rs2304631 chr16:4475868 A/T cg14951292 chr16:4525986 HMOX2;NMRAL1 0.64 8.37 0.42 1.66e-15 Schizophrenia; CRC cis rs782590 0.694 rs2627775 chr2:55877113 C/T cg18811423 chr2:55921094 PNPT1 0.71 12.4 0.56 3.23e-29 Metabolic syndrome; CRC cis rs60871478 1.000 rs34761279 chr7:794471 A/G cg13844804 chr7:814759 HEATR2 0.69 8.11 0.41 9.89e-15 Cerebrospinal P-tau181p levels; CRC trans rs12599106 0.792 rs76039834 chr16:34598453 G/A cg11235426 chr6:292522 DUSP22 -0.56 -8.0 -0.4 2.21e-14 Menopause (age at onset); CRC cis rs3126085 0.935 rs6675889 chr1:152213066 G/A cg09127314 chr1:152161683 NA 0.47 6.04 0.32 4.25e-9 Atopic dermatitis; CRC cis rs7811142 0.830 rs61735533 chr7:99955866 G/A cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.61 7.95 0.4 3e-14 Platelet count; CRC cis rs7586879 0.789 rs13035239 chr2:25134000 T/A cg22495460 chr2:25135724 ADCY3 -0.9 -14.95 -0.64 6.53e-39 Body mass index; CRC cis rs9788682 1.000 rs12441426 chr15:78812329 T/C cg06917634 chr15:78832804 PSMA4 -0.48 -5.79 -0.3 1.65e-8 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; CRC cis rs2836950 0.565 rs8130320 chr21:40580258 C/T cg06238570 chr21:40685208 BRWD1 -0.57 -8.43 -0.42 1.09e-15 Menarche (age at onset); CRC cis rs6502050 0.667 rs9892469 chr17:80093657 T/C cg22110888 chr17:80059540 CCDC57 0.4 6.41 0.33 5.11e-10 Life satisfaction; CRC cis rs6502050 0.835 rs8071425 chr17:80117335 C/T cg13198984 chr17:80129470 CCDC57 -0.46 -8.17 -0.41 6.53e-15 Life satisfaction; CRC cis rs853679 0.517 rs3823180 chr6:28061744 G/A cg23161317 chr6:28129485 ZNF389 0.52 6.35 0.33 6.97e-10 Depression; CRC cis rs2836974 0.549 rs34160989 chr21:40554118 C/G cg11890956 chr21:40555474 PSMG1 0.74 7.88 0.4 4.86e-14 Cognitive function; CRC cis rs7659604 0.539 rs1507995 chr4:122748308 G/A cg20573242 chr4:122745356 CCNA2 0.58 8.67 0.43 1.94e-16 Type 2 diabetes; CRC cis rs28386778 0.897 rs2584627 chr17:61901439 T/C cg22520471 chr17:61851767 DDX42;CCDC47 0.76 11.71 0.54 1.01e-26 Prudent dietary pattern; CRC cis rs6502050 0.835 rs62080004 chr17:80079079 C/T cg09264619 chr17:80180166 NA 0.37 6.13 0.32 2.47e-9 Life satisfaction; CRC cis rs4665809 0.878 rs35709953 chr2:26334997 G/A cg27170947 chr2:26402098 FAM59B 0.51 6.11 0.32 2.81e-9 Gut microbiome composition (summer); CRC cis rs28374715 0.662 rs28587487 chr15:41495460 C/T cg18705301 chr15:41695430 NDUFAF1 -0.93 -13.84 -0.61 1.2e-34 Ulcerative colitis; CRC cis rs11997175 0.819 rs6415400 chr8:33783714 C/T cg04338863 chr8:33670619 NA 0.37 6.07 0.32 3.5e-9 Body mass index; CRC cis rs35146811 0.844 rs12705071 chr7:99682026 T/C cg13334819 chr7:99746414 C7orf59 -0.56 -7.12 -0.37 6.88e-12 Coronary artery disease; CRC trans rs7448080 0.702 rs1422867 chr5:123306950 T/C cg23202058 chr4:185139648 ENPP6 0.59 6.06 0.32 3.77e-9 Alcohol dependence (age at onset); CRC cis rs3617 0.652 rs60332615 chr3:52867595 C/A cg11645453 chr3:52864694 ITIH4 -0.46 -9.15 -0.45 5.96e-18 Red blood cell count;Autism spectrum disorder or schizophrenia; CRC cis rs1707322 0.681 rs12048866 chr1:46117492 T/G cg06784218 chr1:46089804 CCDC17 0.64 12.01 0.55 8.37e-28 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs2882667 0.898 rs13182437 chr5:138387149 T/C cg09476006 chr5:138032270 NA 0.44 7.31 0.37 2.03e-12 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs7618915 0.547 rs12487591 chr3:52642936 A/T cg08222913 chr3:52553049 STAB1 -0.32 -5.94 -0.31 7.35e-9 Bipolar disorder; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg11100077 chr12:56546410 MYL6B 0.46 6.23 0.32 1.4e-9 Anxiety disorder; CRC trans rs56176327 0.583 rs7613603 chr3:49812866 C/T cg21665057 chr3:196295764 WDR53;FBXO45 0.61 6.76 0.35 6.4e-11 Intelligence (multi-trait analysis); CRC cis rs2760061 0.626 rs635563 chr1:228136834 C/T cg02753203 chr1:228287806 NA -0.69 -10.53 -0.5 1.55e-22 Diastolic blood pressure; CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg09723155 chr17:79633271 C17orf90;CCDC137 -0.5 -5.97 -0.31 6.06e-9 Diisocyanate-induced asthma; CRC cis rs13108904 0.935 rs1732100 chr4:1281761 C/T cg05665937 chr4:1216051 CTBP1 -0.37 -5.61 -0.3 4.4e-8 Obesity-related traits; CRC cis rs7827545 1.000 rs6578235 chr8:135568022 C/T cg07299736 chr8:135490787 ZFAT -0.38 -6.47 -0.34 3.48e-10 Hypertension (SNP x SNP interaction); CRC cis rs7584330 0.744 rs10929235 chr2:238380272 A/G cg16989719 chr2:238392110 NA -0.45 -7.64 -0.39 2.32e-13 Prostate cancer; CRC cis rs73206853 0.841 rs56122570 chr12:110816291 G/A cg12870014 chr12:110450643 ANKRD13A 0.75 8.12 0.41 9.6e-15 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC cis rs6076065 0.755 rs3746734 chr20:23349765 C/T cg11657817 chr20:23433608 CST11 0.44 6.58 0.34 1.84e-10 Facial morphology (factor 15, philtrum width); CRC cis rs2153535 0.580 rs2327051 chr6:8441150 A/G cg07606381 chr6:8435919 SLC35B3 -0.67 -10.72 -0.51 3.37e-23 Motion sickness; CRC trans rs6550704 0.687 rs9865314 chr3:22634337 A/G cg11916186 chr1:36689760 THRAP3 -0.42 -6.19 -0.32 1.82e-9 Daytime sleep phenotypes; CRC cis rs394563 0.591 rs237012 chr6:149729198 T/C cg07828024 chr6:149772892 ZC3H12D -0.48 -9.06 -0.45 1.22e-17 Dupuytren's disease; CRC cis rs72781680 0.898 rs72798049 chr2:23958002 C/G cg08917208 chr2:24149416 ATAD2B 0.86 8.45 0.42 9.69e-16 Lymphocyte counts; CRC cis rs17539620 0.624 rs117591255 chr6:154839118 G/A cg20019720 chr6:154832845 CNKSR3 0.5 8.09 0.41 1.13e-14 Lipoprotein (a) levels; CRC cis rs13191362 1.000 rs13218900 chr6:163081638 T/C cg14584255 chr6:163149320 PACRG;PARK2 0.43 6.14 0.32 2.38e-9 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs1448094 0.511 rs61930074 chr12:86218759 G/C cg25456477 chr12:86230367 RASSF9 0.35 6.05 0.32 4.01e-9 Major depressive disorder; CRC trans rs17112901 1.000 rs17669480 chr10:102066065 T/C cg12052765 chr10:50816963 SLC18A3;CHAT -0.48 -6.22 -0.32 1.49e-9 Obesity-related traits; CRC cis rs875971 0.862 rs6944374 chr7:65686929 C/G cg12463550 chr7:65579703 CRCP -0.52 -7.03 -0.36 1.22e-11 Aortic root size; CRC trans rs10504229 1.000 rs7007805 chr8:58179327 G/A cg04077850 chr5:125800366 GRAMD3 0.37 6.27 0.33 1.15e-9 Developmental language disorder (linguistic errors); CRC cis rs6089584 0.853 rs1740367 chr20:60574834 C/T cg18761221 chr20:60518478 NA 0.52 8.55 0.43 4.59e-16 Body mass index; CRC cis rs4240897 0.835 rs4845891 chr1:12042506 T/C cg13216073 chr1:12042593 MFN2 0.63 10.59 0.5 9.54e-23 Tuberculosis; CRC trans rs1005277 0.579 rs1621040 chr10:38497232 T/C cg23533926 chr12:111358616 MYL2 -0.56 -8.7 -0.43 1.65e-16 Extrinsic epigenetic age acceleration; CRC cis rs17376456 0.542 rs1453003 chr5:93151611 T/C cg25358565 chr5:93447407 FAM172A -0.63 -7.48 -0.38 6.82e-13 Diabetic retinopathy; CRC cis rs6502050 0.698 rs6502076 chr17:80121978 A/G cg19223190 chr17:80058835 NA 0.39 6.23 0.32 1.43e-9 Life satisfaction; CRC cis rs12950390 0.853 rs56387656 chr17:45860189 C/G cg24803719 chr17:45855879 NA -0.32 -6.98 -0.36 1.63e-11 IgG glycosylation; CRC cis rs2576037 0.523 rs4890705 chr18:44509758 A/G cg23996704 chr18:44553084 KATNAL2 -0.37 -7.36 -0.38 1.52e-12 Personality dimensions; CRC cis rs12983728 1.000 rs12983728 chr19:58671267 G/A cg24884572 chr19:58661833 ZNF329 0.74 8.09 0.41 1.16e-14 Cholesterol, total; CRC cis rs4654899 0.606 rs651085 chr1:21097783 A/G cg02927042 chr1:21476669 EIF4G3 0.38 5.9 0.31 9.21e-9 Superior frontal gyrus grey matter volume; CRC cis rs6500395 0.775 rs7198145 chr16:48666500 A/C cg04672837 chr16:48644449 N4BP1 0.42 6.43 0.33 4.4e-10 Response to tocilizumab in rheumatoid arthritis; CRC cis rs1153858 1.000 rs56669689 chr15:45637729 A/C cg14582100 chr15:45693742 SPATA5L1 0.28 5.87 0.31 1.07e-8 Homoarginine levels; CRC cis rs832540 0.618 rs41106 chr5:56145057 G/T cg03609598 chr5:56110824 MAP3K1 -0.43 -5.8 -0.3 1.54e-8 Coronary artery disease; CRC cis rs3026445 0.928 rs12296821 chr12:110629266 A/G cg12870014 chr12:110450643 ANKRD13A 0.39 6.16 0.32 2.12e-9 QT interval; CRC cis rs9467711 0.659 rs35433030 chr6:26529890 G/A cg08501292 chr6:25962987 TRIM38 0.88 6.11 0.32 2.84e-9 Autism spectrum disorder or schizophrenia; CRC cis rs477895 0.713 rs12575642 chr11:63979643 G/T cg19465662 chr11:63993652 NUDT22;TRPT1 0.72 8.88 0.44 4.49e-17 Mean platelet volume; CRC cis rs11098499 0.618 rs6858383 chr4:120296772 T/C cg24375607 chr4:120327624 NA 0.51 7.86 0.4 5.5e-14 Corneal astigmatism; CRC cis rs10504229 0.595 rs76447299 chr8:58117395 A/G cg02290350 chr8:58132656 NA -0.58 -8.16 -0.41 7.29e-15 Developmental language disorder (linguistic errors); CRC cis rs2985684 0.779 rs12160 chr14:50091932 T/A cg23565292 chr14:50234668 KLHDC2 -0.4 -5.64 -0.3 3.75e-8 Carotid intima media thickness; CRC cis rs4819052 0.724 rs9753962 chr21:46661384 G/T cg19498844 chr21:46707878 POFUT2;LOC642852 0.77 10.99 0.52 3.97e-24 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs6502050 0.799 rs34795957 chr17:80118013 G/A cg02741985 chr17:80059408 CCDC57 0.43 7.17 0.37 5.1e-12 Life satisfaction; CRC cis rs3087591 0.919 rs2952983 chr17:29470288 G/C cg24425628 chr17:29625626 OMG;NF1 0.81 14.08 0.61 1.46e-35 Hip circumference; CRC cis rs6951245 0.744 rs10265758 chr7:1172518 C/T cg20603222 chr7:1096387 C7orf50;GPR146 -0.59 -7.51 -0.38 5.55e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs875971 0.964 rs778723 chr7:65829497 T/C cg12463550 chr7:65579703 CRCP 0.48 6.96 0.36 1.89e-11 Aortic root size; CRC cis rs116095464 0.558 rs9688136 chr5:229348 T/C cg22496380 chr5:211416 CCDC127 -0.86 -10.04 -0.48 7.52e-21 Breast cancer; CRC cis rs1552244 0.832 rs3732968 chr3:10013273 A/G cg02579736 chr3:10068473 FANCD2;CIDECP 0.96 12.39 0.56 3.27e-29 Alzheimer's disease; CRC cis rs4722166 0.695 rs56061963 chr7:22800397 T/C cg05472934 chr7:22766657 IL6 0.66 10.78 0.51 2.13e-23 Lung cancer; CRC cis rs11212617 1.000 rs11212617 chr11:108283161 G/T cg12106634 chr11:108092400 ATM;NPAT 0.4 5.8 0.3 1.59e-8 Response to metformin in type 2 diabetes (glycemic); CRC cis rs9733 0.519 rs1336900 chr1:150679033 C/T cg17724175 chr1:150552817 MCL1 0.58 9.4 0.46 9.86e-19 Tonsillectomy; CRC cis rs9322193 1.000 rs9399693 chr6:149933854 C/T cg07701084 chr6:150067640 NUP43 0.53 7.73 0.39 1.36e-13 Lung cancer; CRC cis rs2576037 0.583 rs8098948 chr18:44512332 C/A cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.63 10.7 0.51 4.08e-23 Personality dimensions; CRC cis rs1552244 1.000 rs2160869 chr3:10079255 G/A cg18598329 chr3:10140678 FANCD2;C3orf24 -0.89 -12.94 -0.58 2.96e-31 Alzheimer's disease; CRC cis rs2075371 0.966 rs2544224 chr7:133995832 A/G cg20476274 chr7:133979776 SLC35B4 0.8 14.37 0.62 1.08e-36 Mean platelet volume; CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg21215323 chr15:41220556 DLL4 -0.49 -6.09 -0.32 3.1e-9 Diisocyanate-induced asthma; CRC cis rs11785400 1.000 rs4518642 chr8:143737396 T/C cg10596483 chr8:143751796 JRK 0.49 6.85 0.35 3.66e-11 Schizophrenia; CRC cis rs7216064 0.953 rs1966410 chr17:65837215 T/C cg12091567 chr17:66097778 LOC651250 -0.62 -7.82 -0.4 7.46e-14 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CRC cis rs1218582 0.803 rs7531728 chr1:154840516 C/A cg03351412 chr1:154909251 PMVK 0.51 7.63 0.39 2.6e-13 Prostate cancer; CRC cis rs57221529 0.766 rs72703042 chr5:579269 C/T cg16447950 chr5:562315 NA -0.83 -10.81 -0.51 1.71e-23 Lung disease severity in cystic fibrosis; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg11668638 chr6:42952412 PPP2R5D 0.48 6.81 0.35 4.59e-11 Response to antipsychotic treatment; CRC cis rs9549328 0.614 rs35872678 chr13:113617231 A/T cg25790453 chr13:113633590 MCF2L 0.44 7.62 0.39 2.75e-13 Systolic blood pressure; CRC cis rs13064411 0.735 rs13098166 chr3:113210038 A/G cg18753928 chr3:113234510 CCDC52 -0.7 -10.83 -0.51 1.45e-23 Response to simvastatin treatment (PCSK9 protein level change); CRC cis rs9891119 0.526 rs4103200 chr17:40507065 G/C cg06270615 chr17:40516068 STAT3 -0.36 -7.66 -0.39 2.05e-13 Multiple sclerosis;Crohn's disease; CRC cis rs10499694 0.933 rs7778349 chr7:50593157 C/T cg18232548 chr7:50535776 DDC -0.4 -6.11 -0.32 2.76e-9 Body mass index; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg04833878 chr14:104167610 KLC1;XRCC3 -0.38 -6.79 -0.35 5.3e-11 Liver disease severity in Alagille syndrome; CRC cis rs2072499 1.000 rs2241107 chr1:156182710 C/T cg24450063 chr1:156163899 SLC25A44 -1.11 -25.56 -0.82 3.8e-80 Testicular germ cell tumor; CRC cis rs17376456 0.569 rs10057664 chr5:93182274 C/T cg09848695 chr5:92956644 FAM172A;MIR2277 -0.54 -6.22 -0.32 1.52e-9 Diabetic retinopathy; CRC cis rs372883 0.600 rs1153277 chr21:30666867 A/T cg08807101 chr21:30365312 RNF160 -0.57 -7.99 -0.4 2.32e-14 Pancreatic cancer; CRC cis rs9381040 0.655 rs2268187 chr6:41042993 G/A cg09580153 chr6:41068724 NFYA;LOC221442 -0.44 -6.33 -0.33 8.13e-10 Alzheimer's disease (late onset); CRC cis rs4713118 0.615 rs57252182 chr6:27720249 C/A cg12273811 chr6:28175739 NA 0.45 6.48 0.34 3.4e-10 Parkinson's disease; CRC cis rs2836974 0.897 rs2836973 chr21:40654928 A/G cg06238570 chr21:40685208 BRWD1 0.73 10.25 0.49 1.42e-21 Cognitive function; CRC cis rs6585424 1.000 rs35497678 chr10:81921078 C/T cg11900509 chr10:81946545 ANXA11 -0.72 -8.81 -0.44 7.22e-17 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs9828933 0.882 rs3733127 chr3:63988174 C/T cg16258503 chr3:63850278 ATXN7;THOC7 -0.55 -6.15 -0.32 2.26e-9 Type 2 diabetes; CRC cis rs1348850 0.831 rs1345139 chr2:178449791 G/T cg22681709 chr2:178499509 PDE11A -0.33 -6.26 -0.33 1.22e-9 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs7259376 0.869 rs8110636 chr19:22600827 G/A cg02657401 chr19:22469223 NA 0.31 6.65 0.34 1.23e-10 Menopause (age at onset); CRC cis rs9463078 0.774 rs9357480 chr6:45219512 G/A cg25276700 chr6:44698697 NA -0.27 -6.55 -0.34 2.19e-10 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; CRC cis rs67311347 1.000 rs13095055 chr3:40505666 G/T cg24209194 chr3:40518798 ZNF619 -0.43 -6.39 -0.33 5.61e-10 Renal cell carcinoma; CRC cis rs3096299 0.509 rs4785691 chr16:89597221 A/G cg16743903 chr16:89593216 SPG7 -0.39 -5.93 -0.31 7.85e-9 Multiple myeloma (IgH translocation); CRC cis rs1881797 0.872 rs2141544 chr1:247690800 A/G cg21399703 chr1:247681439 NA 0.52 9.69 0.47 1.07e-19 Acute lymphoblastic leukemia (childhood); CRC cis rs12931792 0.687 rs8057425 chr16:30182541 T/C cg17640201 chr16:30407289 ZNF48 0.44 6.38 0.33 6.1e-10 Tonsillectomy; CRC cis rs7208859 0.673 rs9909497 chr17:29173228 C/A cg14008862 chr17:28927542 LRRC37B2 0.55 5.74 0.3 2.1e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs12142240 0.660 rs72890715 chr1:46852077 A/G cg00530320 chr1:46809349 NSUN4 0.59 8.07 0.41 1.35e-14 Menopause (age at onset); CRC cis rs597539 0.617 rs598353 chr11:68635770 C/A cg04772025 chr11:68637568 NA 0.51 8.11 0.41 1.04e-14 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC trans rs10021731 0.718 rs10028232 chr4:115408800 G/A cg25927708 chr2:119603813 EN1 -0.33 -6.01 -0.31 4.92e-9 Optic disc area; CRC cis rs11948739 0.573 rs12332505 chr5:130337348 T/G cg08523029 chr5:130500466 HINT1 -0.44 -5.76 -0.3 1.98e-8 Pediatric bone mineral content (hip); CRC cis rs4478858 0.684 rs7549343 chr1:31752260 A/G cg00250761 chr1:31883323 NA -0.44 -8.59 -0.43 3.52e-16 Alcohol dependence; CRC cis rs10504229 0.683 rs7459958 chr8:58111905 G/T cg22535103 chr8:58192502 C8orf71 -0.7 -9.2 -0.45 4.33e-18 Developmental language disorder (linguistic errors); CRC cis rs4862750 0.914 rs6553026 chr4:187875648 C/T cg03452623 chr4:187889614 NA -0.9 -20.19 -0.74 1.56e-59 Lobe attachment (rater-scored or self-reported); CRC cis rs7666738 0.830 rs13122054 chr4:98972974 G/A cg05340658 chr4:99064831 C4orf37 0.6 9.36 0.46 1.34e-18 Colonoscopy-negative controls vs population controls; CRC trans rs2228479 0.867 rs62052185 chr16:89969254 C/T cg21302420 chr1:112162376 RAP1A 0.7 6.56 0.34 2.06e-10 Skin colour saturation; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg11599998 chr3:160283537 KPNA4 0.36 6.01 0.31 4.95e-9 Liver disease severity in Alagille syndrome; CRC cis rs17253792 0.545 rs17745459 chr14:56008549 T/A cg01858014 chr14:56050164 KTN1 -0.83 -6.74 -0.35 7.07e-11 Putamen volume; CRC cis rs6952808 0.510 rs13227554 chr7:2048220 G/C cg14004847 chr7:1930337 MAD1L1 0.43 6.14 0.32 2.38e-9 Bipolar disorder and schizophrenia; CRC cis rs3820068 0.705 rs11589076 chr1:15827027 C/T cg27534772 chr1:16042836 PLEKHM2 0.41 6.94 0.36 2.06e-11 Systolic blood pressure; CRC cis rs9611565 0.559 rs5751160 chr22:42175695 A/G cg17554472 chr22:41940697 POLR3H 0.56 5.76 0.3 1.93e-8 Vitiligo; CRC cis rs2404602 0.583 rs12907668 chr15:76589767 A/T cg00316803 chr15:76480434 C15orf27 -0.42 -7.3 -0.37 2.17e-12 Blood metabolite levels; CRC cis rs853679 0.546 rs493161 chr6:27850714 A/T cg26587870 chr6:27730563 NA -0.62 -6.08 -0.32 3.36e-9 Depression; CRC cis rs6460942 0.915 rs62448593 chr7:12436845 G/C cg20607287 chr7:12443886 VWDE -0.68 -7.26 -0.37 2.76e-12 Coronary artery disease; CRC cis rs4481887 0.861 rs4295906 chr1:248429861 C/T cg13385794 chr1:248469461 NA 0.42 7.59 0.39 3.26e-13 Common traits (Other); CRC cis rs3849570 0.961 rs3772912 chr3:81698481 A/G cg07356753 chr3:81810745 GBE1 -0.55 -7.45 -0.38 8.3e-13 Waist circumference;Body mass index; CRC cis rs12995491 0.731 rs34991383 chr2:88500337 T/G cg04511125 chr2:88470314 THNSL2 -0.43 -6.22 -0.32 1.53e-9 Response to metformin (IC50); CRC cis rs10782582 0.569 rs74090722 chr1:76197262 A/G cg03433033 chr1:76189801 ACADM -0.44 -6.53 -0.34 2.54e-10 Daytime sleep phenotypes; CRC trans rs61931739 0.534 rs4931770 chr12:34044479 G/T cg26384229 chr12:38710491 ALG10B 0.53 6.76 0.35 6.43e-11 Morning vs. evening chronotype; CRC cis rs7615952 0.599 rs12486459 chr3:125741465 T/G cg02772935 chr3:125709198 NA -0.5 -5.71 -0.3 2.53e-8 Blood pressure (smoking interaction); CRC cis rs7044106 0.791 rs735109 chr9:123488879 C/T cg09419670 chr9:123605666 PSMD5;LOC253039 0.76 12.36 0.56 4.2e-29 Hip circumference adjusted for BMI; CRC cis rs4481887 0.927 rs4472779 chr1:248474603 G/A cg13385794 chr1:248469461 NA 0.38 6.76 0.35 6.25e-11 Common traits (Other); CRC cis rs796364 1.000 rs281774 chr2:200814572 C/T cg12253985 chr2:200820533 C2orf60;C2orf47 0.59 6.55 0.34 2.19e-10 Schizophrenia; CRC cis rs4713118 0.513 rs9368547 chr6:28028067 A/G cg15786705 chr6:28176104 NA 0.58 8.14 0.41 8.31e-15 Parkinson's disease; CRC cis rs6504950 0.566 rs7208403 chr17:53046667 C/A cg19360675 chr17:53046073 COX11;STXBP4 0.46 6.86 0.35 3.5e-11 Breast cancer; CRC cis rs6952808 0.964 rs10950400 chr7:1882470 C/T cg21782813 chr7:2030301 MAD1L1 0.46 7.68 0.39 1.88e-13 Bipolar disorder and schizophrenia; CRC trans rs6703335 0.870 rs10803142 chr1:243598234 A/G cg14507137 chr6:158980977 TMEM181 0.46 6.58 0.34 1.9e-10 Schizophrenia;Schizophrenia, schizoaffective disorder or bipolar disorder; CRC cis rs4700695 0.764 rs152941 chr5:65241446 A/G cg21114390 chr5:65439923 SFRS12 0.57 6.88 0.35 3.05e-11 Facial morphology (factor 19); CRC cis rs826838 1.000 rs1719830 chr12:39096992 T/G cg13010199 chr12:38710504 ALG10B -0.4 -5.9 -0.31 9.26e-9 Heart rate; CRC cis rs801193 0.569 rs2659908 chr7:66160822 G/A cg18252515 chr7:66147081 NA -0.42 -6.0 -0.31 5.25e-9 Aortic root size; CRC cis rs9326248 1.000 rs3736120 chr11:117032125 G/T cg26566898 chr11:117069891 TAGLN 0.44 9.48 0.46 5.22e-19 Blood protein levels; CRC cis rs1862618 0.853 rs252887 chr5:56166188 A/G cg24531977 chr5:56204891 C5orf35 -0.84 -10.88 -0.51 9.11e-24 Initial pursuit acceleration; CRC cis rs875971 0.862 rs778702 chr7:65864835 G/A cg11764359 chr7:65958608 NA 0.59 9.14 0.45 6.48e-18 Aortic root size; CRC cis rs1552244 0.572 rs68121641 chr3:10165845 T/A cg16606324 chr3:10149918 C3orf24 0.66 7.74 0.39 1.19e-13 Alzheimer's disease; CRC cis rs9303401 0.659 rs62083410 chr17:56964386 T/C cg10487724 chr17:56770010 TEX14;RAD51C 0.76 9.53 0.47 3.57e-19 Cognitive test performance; CRC trans rs2303319 0.504 rs56009150 chr2:162598582 T/C cg01919652 chr6:150259930 NA -0.69 -5.99 -0.31 5.48e-9 Cognitive function; CRC cis rs9462027 0.628 rs2764207 chr6:34712998 A/G cg07306190 chr6:34760872 UHRF1BP1 -0.35 -6.25 -0.33 1.28e-9 Systemic lupus erythematosus; CRC cis rs3772130 0.962 rs28660600 chr3:121482637 G/A cg20356878 chr3:121714668 ILDR1 0.51 7.9 0.4 4.1e-14 Cognitive performance; CRC cis rs1707322 1.000 rs4660335 chr1:46474718 C/T cg03146154 chr1:46216737 IPP 0.57 7.8 0.39 8.36e-14 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs524281 0.692 rs10791845 chr11:65834340 C/G cg14036092 chr11:66035641 RAB1B 0.46 6.21 0.32 1.62e-9 Electroencephalogram traits; CRC cis rs2249694 1.000 rs4240522 chr10:135355557 C/T cg16964102 chr10:135390573 NA -0.43 -7.04 -0.36 1.11e-11 Obesity-related traits; CRC cis rs67311347 1.000 rs73078164 chr3:40480289 G/A cg24209194 chr3:40518798 ZNF619 0.42 6.03 0.32 4.34e-9 Renal cell carcinoma; CRC cis rs79839061 0.610 rs73207794 chr4:872020 T/C cg07828340 chr4:882639 GAK 1.11 10.34 0.5 6.94e-22 Intelligence (multi-trait analysis); CRC cis rs6484504 0.625 rs7112412 chr11:31370271 T/C cg14844989 chr11:31128820 NA 0.35 6.3 0.33 9.75e-10 Red blood cell count; CRC cis rs968567 0.539 rs174560 chr11:61581764 T/C cg00603274 chr11:61596626 FADS2 -0.48 -6.89 -0.36 2.85e-11 Blood metabolite levels;Rheumatoid arthritis;Vitiligo;Glycerophospholipid levels; CRC cis rs11696501 0.688 rs6073850 chr20:44301084 C/T cg11783356 chr20:44313418 WFDC10B -0.43 -5.72 -0.3 2.34e-8 Brain structure; CRC cis rs561341 1.000 rs521919 chr17:30298039 G/T cg19193384 chr17:30244184 NA -0.53 -6.88 -0.35 3.1e-11 Hip circumference adjusted for BMI; CRC cis rs7927592 0.913 rs948316 chr11:68309670 G/T cg16797656 chr11:68205561 LRP5 0.36 5.72 0.3 2.36e-8 Total body bone mineral density; CRC trans rs7937682 0.883 rs484834 chr11:111465761 G/C cg18187862 chr3:45730750 SACM1L 0.43 6.14 0.32 2.38e-9 Primary sclerosing cholangitis; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg02854695 chr19:50832032 KCNC3 -0.38 -5.97 -0.31 6.29e-9 Myopia (pathological); CRC cis rs208520 0.837 rs208498 chr6:66931560 G/A cg07460842 chr6:66804631 NA -0.95 -12.38 -0.56 3.81e-29 Exhaled nitric oxide output; CRC cis rs2281845 0.826 rs4915214 chr1:201076290 T/A cg22815214 chr1:201083145 CACNA1S 0.58 9.37 0.46 1.22e-18 Permanent tooth development; CRC trans rs9291683 0.530 rs4235346 chr4:9945296 C/T cg26043149 chr18:55253948 FECH -0.54 -8.27 -0.41 3.35e-15 Bone mineral density; CRC cis rs7618915 0.571 rs6798246 chr3:52599922 G/A cg07507251 chr3:52567010 NT5DC2 0.46 6.73 0.35 7.48e-11 Bipolar disorder; CRC cis rs7617773 0.780 rs4130522 chr3:48352313 G/A cg11946769 chr3:48343235 NME6 0.73 9.79 0.47 4.96e-20 Coronary artery disease; CRC cis rs728616 0.867 rs1983776 chr10:81663695 C/T cg05935833 chr10:81318306 SFTPA2 -0.7 -7.74 -0.39 1.21e-13 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs10927875 0.541 rs1763607 chr1:16337509 G/A cg10494257 chr1:16342123 HSPB7 0.44 6.12 0.32 2.65e-9 Dilated cardiomyopathy; CRC cis rs12760731 0.565 rs35038893 chr1:178168417 C/T cg00404053 chr1:178313656 RASAL2 1.05 10.93 0.52 6.36e-24 Obesity-related traits; CRC cis rs10256972 0.552 rs2949192 chr7:1203841 C/T cg03188948 chr7:1209495 NA 0.53 8.02 0.4 1.89e-14 Longevity;Endometriosis; CRC trans rs2048656 0.605 rs13249234 chr8:9650401 T/C cg06636001 chr8:8085503 FLJ10661 0.53 7.48 0.38 6.81e-13 Schizophrenia; CRC cis rs7086627 0.515 rs1870147 chr10:82212541 A/T cg09626299 chr10:82213104 TSPAN14 -0.37 -6.18 -0.32 1.93e-9 Post bronchodilator FEV1; CRC cis rs7618915 0.547 rs1561337 chr3:52659963 C/T cg05573699 chr3:52720067 GNL3;PBRM1 -0.46 -6.66 -0.34 1.15e-10 Bipolar disorder; CRC cis rs16975963 0.644 rs73037036 chr19:38161070 A/T cg15135657 chr19:38346511 NA -0.47 -6.56 -0.34 2.15e-10 Longevity; CRC cis rs1865760 0.568 rs2032450 chr6:25993114 C/G cg17691542 chr6:26056736 HIST1H1C 0.55 8.51 0.42 6.25e-16 Height; CRC cis rs1865760 0.963 rs1540273 chr6:25924158 T/C cg16482183 chr6:26056742 HIST1H1C 0.55 7.96 0.4 2.84e-14 Height; CRC trans rs61931739 0.500 rs10844862 chr12:34531965 A/T cg26384229 chr12:38710491 ALG10B 0.59 8.77 0.44 9.64e-17 Morning vs. evening chronotype; CRC cis rs2637266 0.505 rs10824434 chr10:78441162 T/C cg18941641 chr10:78392320 NA -0.34 -5.61 -0.3 4.39e-8 Pulmonary function; CRC cis rs1048238 0.846 rs945422 chr1:16345619 T/C cg22431228 chr1:16359049 CLCNKA -0.44 -8.44 -0.42 1.03e-15 Systolic blood pressure; CRC cis rs3126085 0.935 rs7534716 chr1:152198654 A/G cg09127314 chr1:152161683 NA 0.47 6.02 0.31 4.67e-9 Atopic dermatitis; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg26311208 chr1:59012484 OMA1 0.39 6.22 0.32 1.52e-9 Liver disease severity in Alagille syndrome; CRC cis rs933688 0.938 rs6866923 chr5:90669352 A/C cg02339078 chr5:90679543 LOC100129716;ARRDC3 0.97 15.81 0.66 2.74e-42 Smoking behavior; CRC cis rs10540 1.000 rs12788729 chr11:502371 G/A cg03576123 chr11:487126 PTDSS2 -1.04 -10.79 -0.51 1.91e-23 Body mass index; CRC cis rs12325245 0.536 rs71389028 chr16:58663260 G/A cg19824325 chr16:58548873 SETD6 1.0 6.84 0.35 3.87e-11 Schizophrenia; CRC cis rs9527 0.571 rs7904113 chr10:104633114 G/T cg15744005 chr10:104629667 AS3MT -0.38 -7.71 -0.39 1.49e-13 Arsenic metabolism; CRC cis rs2276314 0.857 rs4799409 chr18:33592602 C/T cg19628046 chr18:33552617 C18orf21 0.49 6.68 0.35 1.02e-10 Endometriosis;Drug-induced torsades de pointes; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg06532184 chr4:16227813 FLJ39653;TAPT1 0.37 6.0 0.31 5.26e-9 Liver disease severity in Alagille syndrome; CRC trans rs1814175 0.817 rs1851860 chr11:49861310 A/C cg03929089 chr4:120376271 NA -0.94 -18.29 -0.71 4.76e-52 Height; CRC cis rs561341 1.000 rs484175 chr17:30309041 G/A cg00745463 chr17:30367425 LRRC37B -0.89 -9.87 -0.48 2.65e-20 Hip circumference adjusted for BMI; CRC cis rs3008870 0.920 rs3008865 chr1:67402838 T/C cg08660285 chr1:67390436 MIER1;WDR78 1.0 14.52 0.62 2.96e-37 Lymphocyte percentage of white cells; CRC cis rs736408 0.509 rs3774349 chr3:52722335 A/C cg08222913 chr3:52553049 STAB1 -0.38 -7.43 -0.38 9.54e-13 Bipolar disorder; CRC cis rs2976388 0.533 rs12543368 chr8:143819450 T/C cg05569086 chr8:143859399 LYNX1 -0.39 -6.17 -0.32 1.96e-9 Urinary tract infection frequency; CRC cis rs8058578 1.000 rs7198250 chr16:30746822 C/A cg02466173 chr16:30829666 NA -0.76 -12.1 -0.55 4.09e-28 Multiple myeloma; CRC cis rs9443645 0.509 rs12176511 chr6:79565721 G/A cg09184832 chr6:79620586 NA 0.37 6.2 0.32 1.73e-9 Intelligence (multi-trait analysis); CRC cis rs9372498 0.764 rs4593396 chr6:118722514 A/G cg18833306 chr6:118973337 C6orf204 0.49 6.19 0.32 1.83e-9 Diastolic blood pressure; CRC cis rs13108904 0.967 rs13150571 chr4:1278636 C/G cg05665937 chr4:1216051 CTBP1 0.4 5.8 0.3 1.54e-8 Obesity-related traits; CRC cis rs9900497 0.569 rs2072327 chr17:19651482 G/T cg22552966 chr17:19620595 SLC47A2 -0.37 -6.71 -0.35 8.54e-11 Response to paliperidone in schizophrenia (CGI-S score); CRC cis rs67311347 0.544 rs9877105 chr3:40333366 T/C cg09455208 chr3:40491958 NA 0.32 6.38 0.33 5.99e-10 Renal cell carcinoma; CRC cis rs3791556 0.842 rs55840142 chr2:240106884 G/A cg03281426 chr2:240109471 HDAC4 0.72 9.02 0.45 1.65e-17 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs736408 0.507 rs6445531 chr3:52717282 T/C cg08222913 chr3:52553049 STAB1 -0.34 -6.38 -0.33 6.15e-10 Bipolar disorder; CRC cis rs13315871 1.000 rs78248959 chr3:58455068 G/A cg20936604 chr3:58311152 NA -0.72 -6.7 -0.35 8.82e-11 Cholesterol, total; CRC cis rs6062302 0.548 rs6089940 chr20:62252695 C/T cg06363034 chr20:62225388 GMEB2 -0.44 -6.8 -0.35 5e-11 Glioblastoma; CRC cis rs9660992 0.736 rs72745207 chr1:205251991 C/G cg21643547 chr1:205240462 TMCC2 -0.45 -7.24 -0.37 3.17e-12 Mean corpuscular volume;Mean platelet volume; CRC cis rs4713118 0.662 rs9468277 chr6:28028390 C/A cg15845792 chr6:28175446 NA 0.95 13.73 0.6 3.05e-34 Parkinson's disease; CRC cis rs17213078 0.510 rs17032713 chr2:106886839 T/C cg15412446 chr2:106886593 NA -0.73 -13.89 -0.61 7.95e-35 Facial morphology (factor 23); CRC cis rs10504073 0.584 rs10504070 chr8:49978554 A/G cg00325661 chr8:49890786 NA -0.57 -10.26 -0.49 1.3e-21 Blood metabolite ratios; CRC trans rs853679 1.000 rs13200462 chr6:28218199 A/C cg06606381 chr12:133084897 FBRSL1 -0.74 -7.07 -0.36 9.44e-12 Depression; CRC cis rs7258465 0.965 rs748609 chr19:18560282 T/C cg10790698 chr19:18539756 SSBP4 -0.45 -8.57 -0.43 4.22e-16 Breast cancer; CRC trans rs11098499 0.710 rs6851130 chr4:120133712 G/A cg25214090 chr10:38739885 LOC399744 -0.42 -6.73 -0.35 7.72e-11 Corneal astigmatism; CRC trans rs1005277 0.579 rs2472183 chr10:38392495 T/G cg27523141 chr10:43048294 ZNF37B 0.49 7.21 0.37 3.88e-12 Extrinsic epigenetic age acceleration; CRC cis rs9457247 0.534 rs9356551 chr6:167400345 T/C cg23791538 chr6:167370224 RNASET2 0.48 7.85 0.4 5.97e-14 Crohn's disease; CRC cis rs5769765 0.542 rs5769751 chr22:50242733 T/G cg22709217 chr22:50311962 ALG12;CRELD2 0.9 7.49 0.38 6.2800000000000005e-13 Schizophrenia; CRC cis rs2257205 0.667 rs11651859 chr17:56731926 G/T cg25885038 chr17:56607967 SEPT4 -0.53 -5.79 -0.3 1.62e-8 Pancreatic cancer; CRC cis rs7208859 0.623 rs9916725 chr17:29107471 A/C cg13385521 chr17:29058706 SUZ12P 0.73 8.4 0.42 1.39e-15 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs2797160 1.000 rs1739354 chr6:126017808 G/C cg05901451 chr6:126070800 HEY2 0.39 6.03 0.32 4.46e-9 Endometrial cancer; CRC cis rs1448094 0.511 rs7959372 chr12:86160680 T/C cg18827107 chr12:86230957 RASSF9 -0.38 -5.84 -0.31 1.26e-8 Major depressive disorder; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg18940588 chr22:27053464 MIAT 0.36 6.43 0.33 4.49e-10 Liver disease severity in Alagille syndrome; CRC cis rs6076065 0.775 rs6083114 chr20:23379528 G/T cg11657817 chr20:23433608 CST11 0.55 9.4 0.46 9.91e-19 Facial morphology (factor 15, philtrum width); CRC cis rs9359856 0.623 rs1179903 chr6:90321736 G/T cg13799429 chr6:90582589 CASP8AP2 -0.66 -9.79 -0.47 5.08e-20 Bipolar disorder; CRC cis rs6840360 0.642 rs11099819 chr4:152430178 T/C cg09659197 chr4:152720779 NA 0.33 6.67 0.35 1.08e-10 Intelligence (multi-trait analysis); CRC trans rs6703335 0.870 rs10803142 chr1:243598234 A/G cg10478199 chr2:71175792 ATP6V1B1 0.43 6.12 0.32 2.59e-9 Schizophrenia;Schizophrenia, schizoaffective disorder or bipolar disorder; CRC cis rs1707322 0.752 rs4607935 chr1:46117161 C/T cg06784218 chr1:46089804 CCDC17 0.64 12.01 0.55 8.37e-28 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg01475735 chr3:40494733 NA 0.48 6.74 0.35 6.93e-11 Response to antipsychotic treatment; CRC cis rs7927592 0.956 rs7102273 chr11:68385579 T/C cg01657329 chr11:68192670 LRP5 -0.47 -6.83 -0.35 4.03e-11 Total body bone mineral density; CRC cis rs6540556 0.723 rs9430012 chr1:209900615 G/C cg05527609 chr1:210001259 C1orf107 -0.57 -6.37 -0.33 6.3e-10 Red blood cell count; CRC cis rs7666738 0.753 rs2865957 chr4:99040725 G/A cg17366294 chr4:99064904 C4orf37 0.43 7.16 0.37 5.31e-12 Colonoscopy-negative controls vs population controls; CRC cis rs736408 0.812 rs1075653 chr3:52825528 T/C cg18404041 chr3:52824283 ITIH1 -0.48 -9.91 -0.48 1.97e-20 Bipolar disorder; CRC trans rs951252 0.504 rs11734405 chr4:146081096 C/T cg11528995 chr1:117210575 IGSF3 0.44 6.07 0.32 3.53e-9 Hip circumference; CRC cis rs896854 0.654 rs896847 chr8:95972551 G/A cg16049864 chr8:95962084 TP53INP1 -0.65 -11.83 -0.55 3.9e-27 Type 2 diabetes; CRC cis rs6815814 0.950 rs73236615 chr4:38786869 G/T cg06935464 chr4:38784597 TLR10 0.65 6.92 0.36 2.38e-11 Breast cancer; CRC cis rs6582630 0.519 rs11495724 chr12:38337507 T/C cg13010199 chr12:38710504 ALG10B 0.47 6.37 0.33 6.29e-10 Drug-induced liver injury (flucloxacillin); CRC cis rs7772486 0.837 rs2474354 chr6:146323795 T/A cg23711669 chr6:146136114 FBXO30 0.61 10.23 0.49 1.69e-21 Lobe attachment (rater-scored or self-reported); CRC cis rs2153535 0.580 rs9505450 chr6:8469902 C/T cg07606381 chr6:8435919 SLC35B3 0.68 10.9 0.51 8.26e-24 Motion sickness; CRC cis rs394563 0.517 rs385303 chr6:149779064 C/T cg11245181 chr6:149772854 ZC3H12D -0.51 -7.84 -0.4 6.47e-14 Dupuytren's disease; CRC cis rs9303401 0.659 rs35797125 chr17:56736547 G/A cg10487724 chr17:56770010 TEX14;RAD51C 0.78 9.63 0.47 1.74e-19 Cognitive test performance; CRC cis rs6060987 1 rs6060987 chr20:30427077 T/A cg18721089 chr20:30220636 NA -0.36 -5.93 -0.31 7.48e-9 Mean corpuscular volume; CRC cis rs7412746 0.611 rs1889740 chr1:150799755 C/T cg15448220 chr1:150897856 SETDB1 0.44 6.38 0.33 5.94e-10 Melanoma; CRC cis rs1865760 1.000 rs2071301 chr6:25914263 G/T cg17691542 chr6:26056736 HIST1H1C 0.55 8.29 0.42 2.91e-15 Height; CRC cis rs2243480 1.000 rs34974928 chr7:65364006 T/C cg18252515 chr7:66147081 NA -1.13 -13.15 -0.59 4.8e-32 Diabetic kidney disease; CRC cis rs7617480 0.648 rs6796790 chr3:48780317 G/A cg20833759 chr3:49053208 WDR6;DALRD3 0.67 10.88 0.51 9.12e-24 Subjective well-being (multi-trait analysis);Menarche (age at onset); CRC cis rs6089584 0.853 rs1740367 chr20:60574834 C/T cg06108461 chr20:60628389 TAF4 -0.78 -12.06 -0.55 5.67e-28 Body mass index; CRC cis rs1153858 1.000 rs7494956 chr15:45668565 T/C cg10760299 chr15:45669010 GATM 0.49 7.65 0.39 2.19e-13 Homoarginine levels; CRC cis rs28386778 0.897 rs6504176 chr17:61811920 T/C cg11494091 chr17:61959527 GH2 0.61 10.21 0.49 1.96e-21 Prudent dietary pattern; CRC cis rs9768139 0.733 rs71545585 chr7:158118672 G/A cg06219351 chr7:158114137 PTPRN2 -0.51 -7.6 -0.39 3.07e-13 Calcium levels; CRC cis rs447735 0.587 rs7188458 chr16:89726484 A/G cg01097406 chr16:89675127 NA 0.35 6.63 0.34 1.36e-10 Hemoglobin concentration; CRC cis rs17826219 0.636 rs12946563 chr17:29103166 C/G cg01831904 chr17:28903510 LRRC37B2 -0.62 -6.33 -0.33 8.19e-10 Body mass index; CRC cis rs208520 0.690 rs12201156 chr6:66720874 G/T cg07460842 chr6:66804631 NA 0.98 13.67 0.6 5.54e-34 Exhaled nitric oxide output; CRC cis rs7786808 0.741 rs4909222 chr7:158228095 C/T cg01191920 chr7:158217561 PTPRN2 0.89 17.42 0.69 1.34e-48 Obesity-related traits; CRC cis rs10927875 1.000 rs12138117 chr1:16305279 T/C cg21385522 chr1:16154831 NA -0.64 -8.5 -0.42 6.68e-16 Dilated cardiomyopathy; CRC trans rs9825823 0.617 rs2083264 chr3:61074229 A/G cg00265863 chr1:28286348 XKR8 0.43 6.07 0.32 3.6e-9 Depressive symptom measurement or major depressive disorder; CRC cis rs6121246 0.522 rs6088736 chr20:30195166 C/G cg18721089 chr20:30220636 NA -0.52 -7.93 -0.4 3.54e-14 Mean corpuscular hemoglobin; CRC cis rs713587 0.571 rs2918630 chr2:25314186 A/G cg22495460 chr2:25135724 ADCY3 0.41 6.17 0.32 1.95e-9 Body mass index in non-asthmatics; CRC cis rs3924048 0.574 rs11121930 chr1:12616956 C/A cg00291366 chr1:12616550 NA 0.6 10.8 0.51 1.78e-23 Optic cup area; CRC cis rs4234798 0.500 rs10937793 chr4:7219614 C/T cg18431297 chr4:7219810 SORCS2 0.75 13.3 0.59 1.39e-32 Insulin-like growth factors; CRC cis rs780096 0.526 rs11127013 chr2:27692973 A/G cg12000995 chr2:27665139 KRTCAP3 -0.32 -6.37 -0.33 6.46e-10 Total body bone mineral density; CRC cis rs2832191 1.000 rs2832185 chr21:30483761 C/G cg08807101 chr21:30365312 RNF160 -0.61 -9.96 -0.48 1.36e-20 Dental caries; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg14676443 chr19:58963245 ZNF324B 0.49 6.82 0.35 4.42e-11 Response to antipsychotic treatment; CRC cis rs394563 0.591 rs237026 chr6:149720681 G/A cg07828024 chr6:149772892 ZC3H12D -0.53 -9.9 -0.48 2.13e-20 Dupuytren's disease; CRC cis rs12760731 0.565 rs116253445 chr1:178216962 C/T cg00404053 chr1:178313656 RASAL2 1.03 10.81 0.51 1.61e-23 Obesity-related traits; CRC cis rs1552172 0.845 rs35880546 chr1:145713071 T/C cg11743829 chr1:145714124 CD160 -0.41 -5.88 -0.31 9.92e-9 Breast cancer; CRC cis rs7613875 0.578 rs2624822 chr3:50107219 T/C cg24308560 chr3:49941425 MST1R 0.44 6.9 0.36 2.74e-11 Body mass index; CRC cis rs10512697 0.803 rs71594962 chr5:3578127 A/G cg19473799 chr5:3511975 NA -0.73 -5.8 -0.3 1.53e-8 Immune response to smallpox vaccine (IL-6); CRC cis rs10971721 0.822 rs115554740 chr9:33860886 C/G cg13495928 chr9:33750294 PRSS3 0.55 5.93 0.31 7.7e-9 Body mass index; CRC cis rs6577655 0.517 rs62525562 chr8:135587076 C/T cg17885191 chr8:135476712 NA 0.49 5.73 0.3 2.3e-8 Visceral adipose tissue/subcutaneous adipose tissue ratio; CRC trans rs1005277 0.579 rs1740735 chr10:38497777 A/C cg23533926 chr12:111358616 MYL2 -0.56 -8.73 -0.43 1.3e-16 Extrinsic epigenetic age acceleration; CRC cis rs1018836 0.828 rs10086462 chr8:91558089 A/G cg16814680 chr8:91681699 NA -0.61 -9.38 -0.46 1.14e-18 Ejection fraction in Tripanosoma cruzi seropositivity; CRC cis rs9527 0.568 rs1926036 chr10:104883812 C/T cg15744005 chr10:104629667 AS3MT -0.31 -6.1 -0.32 3.05e-9 Arsenic metabolism; CRC cis rs9296736 1.000 rs9296736 chr6:53924697 A/G cg04374786 chr6:53939321 C6orf142 0.45 7.21 0.37 3.98e-12 Liver enzyme levels (gamma-glutamyl transferase); CRC trans rs2303319 0.504 rs1006428 chr2:162592559 A/C cg22922770 chr7:98923339 ARPC1A -0.67 -5.98 -0.31 5.68e-9 Cognitive function; CRC cis rs7949030 0.626 rs7930896 chr11:62325272 A/G cg22862634 chr11:62369728 EML3;MTA2 0.56 9.95 0.48 1.43e-20 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; CRC cis rs12541635 0.966 rs2217391 chr8:107063126 A/G cg10147462 chr8:107024639 NA 0.44 7.31 0.37 2.06e-12 Age of smoking initiation; CRC cis rs8177253 0.965 rs7638018 chr3:133495461 C/T cg16262614 chr3:133464971 TF -0.33 -5.85 -0.31 1.2e-8 Iron status biomarkers; CRC cis rs501916 1.000 rs599111 chr15:48053334 G/T cg16110827 chr15:48056943 SEMA6D -0.37 -6.1 -0.32 2.98e-9 Inflammatory bowel disease;Ulcerative colitis; CRC cis rs11864453 0.826 rs8062041 chr16:72088964 C/T cg01557791 chr16:72042693 DHODH -0.52 -7.19 -0.37 4.34e-12 Fibrinogen levels; CRC cis rs6500602 0.592 rs4785966 chr16:4518754 C/T cg13763550 chr16:4524223 NMRAL1;HMOX2 -0.42 -5.64 -0.3 3.76e-8 Schizophrenia; CRC cis rs754466 0.605 rs10824578 chr10:79578244 G/C cg26805224 chr10:79626177 DLG5 -0.46 -6.85 -0.35 3.67e-11 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs9487051 0.714 rs6930733 chr6:109631587 T/C cg01475377 chr6:109611718 NA -0.38 -6.73 -0.35 7.55e-11 Reticulocyte fraction of red cells; CRC cis rs7914558 0.966 rs10786725 chr10:104682357 T/C cg04362960 chr10:104952993 NT5C2 0.6 9.16 0.45 5.82e-18 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs2839186 0.709 rs2156117 chr21:47669300 C/A cg13126279 chr21:47581558 C21orf56 -0.46 -7.33 -0.37 1.83e-12 Testicular germ cell tumor; CRC cis rs7614311 0.636 rs73117066 chr3:63926236 A/G cg22134162 chr3:63841271 THOC7 -0.56 -5.95 -0.31 6.75e-9 Lung function (FVC);Lung function (FEV1); CRC cis rs2481665 0.765 rs2481678 chr1:62634020 T/C cg18591186 chr1:62594603 INADL -0.47 -6.65 -0.34 1.2e-10 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs1691799 0.899 rs1168307 chr12:66739539 A/G cg16791601 chr12:66731901 HELB -0.72 -12.55 -0.57 8.32e-30 White blood cell count (basophil); CRC trans rs78049276 0.512 rs6820938 chr4:148395903 A/G cg13149281 chr14:23389818 RBM23;PRMT5 -0.53 -6.81 -0.35 4.69e-11 Pulse pressure; CRC cis rs4604732 0.631 rs12080860 chr1:247623053 A/G cg12758973 chr1:247694275 LOC148824;OR2C3 0.46 6.68 0.35 1.01e-10 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CRC cis rs7301826 0.651 rs10734981 chr12:131297895 C/G cg11011512 chr12:131303247 STX2 0.37 5.62 0.3 4.1e-8 Plasma plasminogen activator levels; CRC cis rs9443645 0.527 rs9352691 chr6:79785607 C/T cg05283184 chr6:79620031 NA -0.45 -6.49 -0.34 3.25e-10 Intelligence (multi-trait analysis); CRC cis rs9399135 0.967 rs6569990 chr6:135365818 C/T cg24558204 chr6:135376177 HBS1L 0.49 7.72 0.39 1.41e-13 Red blood cell count; CRC cis rs10504229 1.000 rs17217047 chr8:58180296 G/A cg02290350 chr8:58132656 NA -0.42 -5.96 -0.31 6.62e-9 Developmental language disorder (linguistic errors); CRC trans rs66573146 1.000 rs55688389 chr4:7030689 C/G cg07817883 chr1:32538562 TMEM39B 1.33 11.14 0.52 1.11e-24 Granulocyte percentage of myeloid white cells; CRC cis rs9467711 0.591 rs13201821 chr6:26057781 A/C cg08501292 chr6:25962987 TRIM38 0.72 7.21 0.37 3.94e-12 Autism spectrum disorder or schizophrenia; CRC cis rs12142240 0.698 rs67200518 chr1:46835777 T/C cg00530320 chr1:46809349 NSUN4 0.6 8.16 0.41 7.02e-15 Menopause (age at onset); CRC cis rs13191362 0.507 rs2849520 chr6:163132038 T/C cg21926612 chr6:163149169 PACRG;PARK2 -0.67 -10.57 -0.5 1.16e-22 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs9393777 0.513 rs1104871 chr6:26665235 T/G cg12292205 chr6:26970375 C6orf41 -0.65 -7.64 -0.39 2.46e-13 Intelligence (multi-trait analysis); CRC cis rs3736485 0.844 rs8041197 chr15:51865877 T/C cg08986416 chr15:51914746 DMXL2 -0.45 -6.54 -0.34 2.35e-10 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs79387448 0.638 rs13405222 chr2:102981891 T/C cg09003973 chr2:102972529 NA 0.85 9.24 0.45 3.2e-18 Gut microbiota (bacterial taxa); CRC cis rs11098499 0.542 rs7677836 chr4:120310638 T/A cg24375607 chr4:120327624 NA 0.51 7.86 0.4 5.5e-14 Corneal astigmatism; CRC cis rs12545109 0.837 rs6474063 chr8:57355545 C/T cg09654669 chr8:57350985 NA -0.42 -6.01 -0.31 5.03e-9 Obesity-related traits; CRC trans rs6703335 0.870 rs10803142 chr1:243598234 A/G cg23981150 chr1:161111090 NA 0.42 6.06 0.32 3.67e-9 Schizophrenia;Schizophrenia, schizoaffective disorder or bipolar disorder; CRC cis rs41271951 0.512 rs76649628 chr1:151041851 A/G cg11822372 chr1:151115635 SEMA6C -0.71 -5.73 -0.3 2.3e-8 Blood protein levels; CRC cis rs7811142 1.000 rs11559117 chr7:100076614 A/G cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.6 7.7 0.39 1.62e-13 Platelet count; CRC cis rs916888 0.610 rs199446 chr17:44813169 G/A cg01570182 chr17:44337453 NA -0.7 -9.1 -0.45 9.12e-18 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg26010175 chr3:135969053 PCCB 0.39 6.42 0.33 4.71e-10 Liver disease severity in Alagille syndrome; CRC trans rs79976124 0.877 rs79507557 chr6:66640908 C/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.77 9.59 0.47 2.32e-19 Type 2 diabetes; CRC trans rs1814175 0.817 rs80244685 chr11:49763292 C/A cg03929089 chr4:120376271 NA -0.9 -15.28 -0.64 3.4e-40 Height; CRC cis rs1153858 1.000 rs67744121 chr15:45677237 C/G cg21132104 chr15:45694354 SPATA5L1 0.59 8.56 0.43 4.47e-16 Homoarginine levels; CRC cis rs453301 0.522 rs1964356 chr8:8853270 G/T cg06636001 chr8:8085503 FLJ10661 0.52 7.6 0.39 3.2e-13 Joint mobility (Beighton score); CRC cis rs10242455 0.702 rs116671616 chr7:98954558 C/T cg18809830 chr7:99032528 PTCD1 -1.06 -7.7 -0.39 1.61e-13 Blood metabolite levels; CRC cis rs875971 0.508 rs10258739 chr7:66062935 A/T cg11764359 chr7:65958608 NA -0.5 -7.78 -0.39 9.27e-14 Aortic root size; CRC cis rs9462027 0.583 rs2814995 chr6:34621171 T/C cg07306190 chr6:34760872 UHRF1BP1 -0.35 -6.29 -0.33 1e-9 Systemic lupus erythematosus; CRC cis rs823143 0.570 rs1361754 chr1:205801872 C/T cg07167872 chr1:205819463 PM20D1 -0.63 -10.02 -0.48 8.57e-21 Monocyte percentage of white cells; CRC cis rs9814567 1.000 rs9835204 chr3:134261342 G/T cg06109529 chr3:134205091 CEP63;ANAPC13 -0.81 -12.19 -0.56 1.92e-28 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs11677416 0.677 rs2856840 chr2:113538604 T/A cg06156847 chr2:113672199 IL1F7 -0.4 -6.09 -0.32 3.12e-9 Response to antipsychotic treatment in schizophrenia (working memory); CRC cis rs7829975 0.902 rs485107 chr8:8581408 C/G cg08975724 chr8:8085496 FLJ10661 -0.41 -6.39 -0.33 5.74e-10 Mood instability; CRC cis rs582297 1 rs582297 chr11:108165407 C/G cg01991180 chr11:108092276 ATM;NPAT 0.41 5.97 0.31 6.04e-9 Eosinophil counts;Eosinophil percentage of white cells;Sum eosinophil basophil counts; CRC cis rs10504229 0.728 rs72650853 chr8:58151473 G/A cg02290350 chr8:58132656 NA -0.51 -6.57 -0.34 1.98e-10 Developmental language disorder (linguistic errors); CRC cis rs1865760 0.964 rs1324084 chr6:25915134 C/T cg16482183 chr6:26056742 HIST1H1C 0.55 7.97 0.4 2.71e-14 Height; CRC cis rs2839186 0.588 rs2839140 chr21:47616080 G/A cg09417038 chr21:47716443 C21orf57 0.38 6.63 0.34 1.35e-10 Testicular germ cell tumor; CRC cis rs7590720 0.819 rs6435931 chr2:216892754 C/G cg12620499 chr2:216877984 MREG 0.94 17.3 0.69 3.73e-48 Alcohol dependence; CRC cis rs11148252 0.740 rs9596642 chr13:52900879 A/G cg12458913 chr13:53173898 NA -0.49 -7.28 -0.37 2.4e-12 Lewy body disease; CRC cis rs35306767 0.953 rs1539174 chr10:974870 C/G cg26597838 chr10:835615 NA 0.81 10.04 0.48 7.3e-21 Eosinophil percentage of granulocytes; CRC cis rs243505 0.898 rs243537 chr7:148408278 A/G cg09806900 chr7:148480153 CUL1 -0.43 -6.01 -0.31 4.96e-9 Inflammatory bowel disease;Crohn's disease; CRC cis rs7584330 0.554 rs56853932 chr2:238428327 T/C cg08992911 chr2:238395768 MLPH 0.52 6.09 0.32 3.17e-9 Prostate cancer; CRC cis rs6570726 0.791 rs1280275 chr6:145892402 C/T cg13319975 chr6:146136371 FBXO30 -0.42 -6.22 -0.32 1.53e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs651907 0.514 rs55654108 chr3:101425703 A/G cg12386194 chr3:101231763 SENP7 0.48 7.1 0.36 7.65e-12 Colorectal cancer; CRC cis rs12220238 1.000 rs10824076 chr10:75886956 G/A cg19889307 chr10:75911429 ADK;AP3M1 0.64 6.49 0.34 3.21e-10 Soluble interleukin-2 receptor subunit alpha; CRC cis rs427941 0.562 rs6970800 chr7:101780471 T/C cg06246474 chr7:101738831 CUX1 0.45 6.9 0.36 2.63e-11 Plasma omega-3 polyunsaturated fatty acid level (eicosapentaenoic acid); CRC cis rs172166 0.652 rs476167 chr6:28065888 T/C cg15786705 chr6:28176104 NA 0.63 8.99 0.44 2.02e-17 Cardiac Troponin-T levels; CRC cis rs7819412 0.668 rs2409715 chr8:11010136 A/T cg27411982 chr8:10470053 RP1L1 -0.36 -5.83 -0.31 1.35e-8 Triglycerides; CRC cis rs782590 0.935 rs6739513 chr2:55749902 G/A cg18811423 chr2:55921094 PNPT1 0.84 15.46 0.65 6.6e-41 Metabolic syndrome; CRC cis rs4321325 0.733 rs4284779 chr2:127946500 T/C cg11380483 chr2:127933992 NA 0.58 7.13 0.37 6.4e-12 Protein C levels; CRC cis rs9486719 0.843 rs3860230 chr6:97036560 T/A cg06623918 chr6:96969491 KIAA0776 -0.82 -11.41 -0.53 1.25e-25 Migraine;Coronary artery disease; CRC cis rs887829 0.570 rs10175809 chr2:234596865 T/A cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.47 -7.32 -0.37 1.97e-12 Metabolic traits;Bilirubin levels;Cholelithiasis-related traits in sickle cell anemia;Metabolite levels;Total bilirubin levels in HIV-1 infection;Serum metabolite levels;Blood metabolite levels; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg09341209 chr11:2422446 TSSC4 0.39 6.29 0.33 1.04e-9 Liver disease severity in Alagille syndrome; CRC trans rs2303319 0.504 rs56371522 chr2:162491109 G/A cg01191114 chr3:48936118 SLC25A20 -0.69 -6.0 -0.31 5.27e-9 Cognitive function; CRC cis rs951366 0.764 rs823143 chr1:205743425 A/C cg17178900 chr1:205818956 PM20D1 0.68 10.18 0.49 2.4e-21 Menarche (age at onset); CRC cis rs2635047 0.967 rs2571016 chr18:44639175 C/G cg20875182 chr18:44561130 TCEB3B;KATNAL2 -0.46 -7.47 -0.38 7.21e-13 Educational attainment; CRC cis rs1451375 1.000 rs4452748 chr7:50625056 A/C cg18232548 chr7:50535776 DDC -0.46 -6.53 -0.34 2.54e-10 Malaria; CRC cis rs7727544 0.716 rs11955347 chr5:131567924 G/A cg14196790 chr5:131705035 SLC22A5 0.35 6.15 0.32 2.18e-9 Blood metabolite levels; CRC trans rs2055729 0.557 rs7000542 chr8:9881135 T/C cg06636001 chr8:8085503 FLJ10661 0.47 6.3 0.33 9.59e-10 Multiple myeloma (hyperdiploidy); CRC cis rs7615952 0.641 rs7640158 chr3:125808011 G/A cg04553112 chr3:125709451 NA -0.53 -6.09 -0.32 3.2e-9 Blood pressure (smoking interaction); CRC cis rs394563 0.934 rs384334 chr6:149796172 C/G cg11245181 chr6:149772854 ZC3H12D -0.52 -8.75 -0.43 1.1e-16 Dupuytren's disease; CRC cis rs2836974 0.584 rs34436313 chr21:40685246 A/G cg17971929 chr21:40555470 PSMG1 -0.68 -9.93 -0.48 1.71e-20 Cognitive function; CRC cis rs7085104 0.513 rs619824 chr10:104581288 G/T cg04362960 chr10:104952993 NT5C2 0.56 8.12 0.41 9.67e-15 Immature fraction of reticulocytes;Schizophrenia; CRC cis rs6831352 0.879 rs29001215 chr4:100051722 T/C cg13256891 chr4:100009986 ADH5 -0.65 -8.86 -0.44 5.21e-17 Alcohol dependence; CRC cis rs875971 0.862 rs801206 chr7:66021966 C/G cg11764359 chr7:65958608 NA -0.59 -8.82 -0.44 6.62e-17 Aortic root size; CRC cis rs651907 0.535 rs13065944 chr3:101473088 G/A cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.59 7.94 0.4 3.21e-14 Colorectal cancer; CRC cis rs2274273 0.624 rs10132453 chr14:55840851 C/T cg10130446 chr14:55658398 DLGAP5 -0.43 -6.13 -0.32 2.46e-9 Protein biomarker; CRC trans rs2727020 0.553 rs4103567 chr11:49255389 C/T cg03929089 chr4:120376271 NA -0.64 -9.91 -0.48 2.03e-20 Coronary artery disease; CRC cis rs10992471 0.603 rs7045572 chr9:95137964 T/C cg14631576 chr9:95140430 CENPP -0.4 -7.15 -0.37 5.48e-12 Visceral adipose tissue/subcutaneous adipose tissue ratio; CRC cis rs4409675 0.576 rs7533918 chr1:28230667 G/A cg23691781 chr1:28212827 C1orf38 0.34 7.88 0.4 4.91e-14 Corneal astigmatism; CRC cis rs919433 0.889 rs788004 chr2:198219032 C/T cg10820045 chr2:198174542 NA 0.48 8.51 0.42 6.21e-16 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC cis rs311392 0.554 rs311388 chr8:55101869 T/A cg06042504 chr8:55087323 NA -0.36 -5.72 -0.3 2.35e-8 Pelvic organ prolapse (moderate/severe); CRC cis rs34034915 1 rs34034915 chr6:27720703 T/TG cg03623178 chr6:28175578 NA 0.61 8.65 0.43 2.32e-16 Hepatitis A; CRC cis rs7945705 0.747 rs1123936 chr11:9003306 A/G cg14711859 chr11:8959438 ASCL3 0.39 6.5 0.34 2.9e-10 Hemoglobin concentration; CRC cis rs11577318 0.853 rs3795684 chr1:26632781 C/T cg04990556 chr1:26633338 UBXN11 -0.48 -6.01 -0.31 5.05e-9 Granulocyte percentage of myeloid white cells; CRC trans rs10403021 0.765 rs4805432 chr19:30069721 A/G cg22044635 chr17:76557109 DNAH17 0.43 5.97 0.31 6.15e-9 Diabetic retinopathy; CRC cis rs12889267 0.722 rs2319626 chr14:21565149 G/C cg02988727 chr14:21567520 ZNF219;C14orf176 0.46 6.93 0.36 2.24e-11 Hematocrit;Resting heart rate; CRC cis rs853679 0.517 rs9368556 chr6:28131153 T/C cg03623178 chr6:28175578 NA 0.98 12.66 0.57 3.31e-30 Depression; CRC cis rs910316 0.763 rs735452 chr14:75497984 A/G cg11812906 chr14:75593930 NEK9 -0.64 -10.1 -0.49 4.58e-21 Height; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg07580707 chr3:14220061 XPC;LSM3 0.41 6.48 0.34 3.38e-10 Liver disease severity in Alagille syndrome; CRC cis rs6860806 0.507 rs272872 chr5:131675864 C/T cg12564285 chr5:131593104 PDLIM4 -0.44 -7.44 -0.38 8.61e-13 Breast cancer; CRC cis rs12477438 0.520 rs4347885 chr2:99804007 G/A cg14399236 chr2:99771627 LIPT1;TSGA10 0.72 11.82 0.55 4.11e-27 Chronic sinus infection; CRC cis rs9894429 0.646 rs7405937 chr17:79597811 G/A cg18240062 chr17:79603768 NPLOC4 0.49 7.68 0.39 1.83e-13 Eye color traits; CRC cis rs870825 0.616 rs6814278 chr4:185644417 G/C cg04058563 chr4:185651563 MLF1IP 0.72 9.3 0.46 2.04e-18 Blood protein levels; CRC trans rs10242455 0.702 rs6977165 chr7:99269397 T/C cg09045935 chr12:6379348 NA 0.92 6.92 0.36 2.36e-11 Blood metabolite levels; CRC cis rs6456156 0.846 rs10946211 chr6:167515489 G/A cg07741184 chr6:167504864 NA -0.35 -6.0 -0.31 5.31e-9 Primary biliary cholangitis; CRC cis rs7552404 0.727 rs11161626 chr1:76260837 C/T cg22875332 chr1:76189707 ACADM 0.57 7.38 0.38 1.33e-12 Blood metabolite levels;Acylcarnitine levels; CRC cis rs919433 1.000 rs2195510 chr2:198161195 A/G cg03934865 chr2:198174659 NA -0.45 -8.11 -0.41 9.84e-15 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC cis rs62244186 0.715 rs11130032 chr3:44704083 G/A cg10263370 chr3:44754102 ZNF502 -0.39 -6.57 -0.34 1.95e-10 Depressive symptoms; CRC cis rs8072100 0.935 rs78737171 chr17:45668760 A/T cg25173405 chr17:45401733 C17orf57 0.42 6.51 0.34 2.84e-10 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC trans rs1005277 0.540 rs11011351 chr10:38030525 A/G cg27523141 chr10:43048294 ZNF37B 0.45 6.46 0.34 3.84e-10 Extrinsic epigenetic age acceleration; CRC cis rs524281 0.861 rs4013917 chr11:65926185 A/G cg16950941 chr11:66035639 RAB1B -0.6 -7.43 -0.38 9.29e-13 Electroencephalogram traits; CRC cis rs597539 0.652 rs10792001 chr11:68637737 G/C cg21963583 chr11:68658836 MRPL21 0.59 10.65 0.51 6e-23 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs7618915 0.547 rs62255362 chr3:52699741 C/G cg18404041 chr3:52824283 ITIH1 -0.43 -8.74 -0.43 1.21e-16 Bipolar disorder; CRC cis rs6952808 0.792 rs2056480 chr7:1954301 A/G cg00106254 chr7:1943704 MAD1L1 0.49 7.3 0.37 2.16e-12 Bipolar disorder and schizophrenia; CRC cis rs832540 0.629 rs3309 chr5:56092779 A/T cg03609598 chr5:56110824 MAP3K1 0.41 5.7 0.3 2.69e-8 Coronary artery disease; CRC cis rs2032447 0.901 rs1540276 chr6:26028819 T/G cg18357526 chr6:26021779 HIST1H4A 0.79 11.94 0.55 1.57e-27 Intelligence (multi-trait analysis); CRC cis rs9311474 0.569 rs7614981 chr3:52566914 G/T cg15147215 chr3:52552868 STAB1 -0.72 -14.31 -0.62 1.9e-36 Electroencephalogram traits; CRC cis rs8020095 0.571 rs8022657 chr14:67390499 C/T cg00791868 chr14:66963628 C14orf53 0.47 6.3 0.33 9.6e-10 Depression (quantitative trait); CRC cis rs1577917 0.771 rs2842601 chr6:86330133 G/A cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.7 -9.25 -0.45 3e-18 Response to antipsychotic treatment; CRC cis rs9381040 0.610 rs9394758 chr6:41017821 C/T cg03644281 chr6:41068752 NFYA;LOC221442 -0.45 -6.42 -0.33 4.71e-10 Alzheimer's disease (late onset); CRC cis rs9323205 0.765 rs2999388 chr14:51654157 A/G cg23942311 chr14:51606299 NA 0.62 9.88 0.48 2.46e-20 Cancer; CRC cis rs1559088 0.600 rs10423965 chr19:33600319 T/G cg17764715 chr19:33622953 WDR88 0.45 6.48 0.34 3.43e-10 Bone ultrasound measurement (broadband ultrasound attenuation); CRC cis rs9911578 1.000 rs302859 chr17:56693132 C/T cg12560992 chr17:57184187 TRIM37 0.9 16.59 0.67 2.38e-45 Intelligence (multi-trait analysis); CRC cis rs9916302 0.904 rs11078897 chr17:37415870 C/T cg07936489 chr17:37558343 FBXL20 -0.84 -13.32 -0.59 1.12e-32 Glomerular filtration rate (creatinine); CRC cis rs7904368 0.754 rs7091240 chr10:16855683 G/A cg14835575 chr10:16859367 RSU1 0.44 5.86 0.31 1.13e-8 Ratio of the peak velocity of the mitral E-Wave divided by the peak velocity of the mitral A-wave.; CRC cis rs12936587 0.564 rs7208561 chr17:17615528 C/T cg04398451 chr17:18023971 MYO15A -0.35 -5.76 -0.3 1.93e-8 Hip circumference;Coronary artery disease or large artery stroke;Coronary heart disease;Coronary artery disease; CRC cis rs3018066 0.589 rs4339284 chr4:107029457 G/A cg01869342 chr4:106983673 TBCK 0.41 5.72 0.3 2.42e-8 Cancer; CRC cis rs853679 0.517 rs9368557 chr6:28131537 T/C cg12172441 chr6:28176163 NA 0.64 7.53 0.38 5.03e-13 Depression; CRC cis rs9826463 0.757 rs77081474 chr3:142294634 T/C cg20824294 chr3:142316082 PLS1 0.42 7.07 0.36 9.31e-12 QRS duration in Tripanosoma cruzi seropositivity; CRC cis rs9811920 0.638 rs10936008 chr3:99686665 C/T cg07805332 chr3:99536008 MIR548G;C3orf26 -0.54 -8.14 -0.41 8.23e-15 Axial length; CRC cis rs875971 0.862 rs10950033 chr7:65739673 A/G cg11764359 chr7:65958608 NA -0.6 -9.24 -0.45 3.1e-18 Aortic root size; CRC cis rs2124969 0.548 rs62175391 chr2:161022588 A/G cg03641300 chr2:160917029 PLA2R1 -0.65 -8.34 -0.42 2.08e-15 Waist circumference adjusted for body mass index; CRC cis rs7772486 0.754 rs6570708 chr6:145989428 C/T cg05347473 chr6:146136440 FBXO30 -0.39 -5.88 -0.31 9.96e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs9908102 0.710 rs7211164 chr17:12917212 C/T cg26162695 chr17:12921313 ELAC2 0.42 5.63 0.3 3.93e-8 Schizophrenia; CRC cis rs1832871 0.683 rs9457224 chr6:158666139 C/T cg07165851 chr6:158734300 TULP4 0.6 7.53 0.38 4.9e-13 Height; CRC trans rs2727020 0.521 rs1909220 chr11:49572109 T/C cg15704280 chr7:45808275 SEPT13 -0.77 -10.35 -0.5 6.44e-22 Coronary artery disease; CRC cis rs853679 0.546 rs200949 chr6:27835435 A/G cg19041857 chr6:27730383 NA -0.66 -6.84 -0.35 3.93e-11 Depression; CRC cis rs7824557 0.603 rs11250130 chr8:11214455 C/T cg08265495 chr8:11212668 TDH -0.32 -5.65 -0.3 3.55e-8 Retinal vascular caliber; CRC cis rs8031584 0.958 rs61997079 chr15:31238271 G/C cg08109568 chr15:31115862 NA -0.54 -8.66 -0.43 2.2e-16 Huntington's disease progression; CRC cis rs1008375 1.000 rs10805357 chr4:17652352 G/A cg02297831 chr4:17616191 MED28 0.44 5.92 0.31 8.19e-9 Parasitemia in Tripanosoma cruzi seropositivity; CRC trans rs931812 1.000 rs4734495 chr8:101917817 C/A cg20993868 chr7:22813445 NA 0.44 8.15 0.41 7.7e-15 Attention deficit hyperactivity disorder and conduct disorder; CRC cis rs12477438 0.798 rs1349779 chr2:99645055 T/C cg26064155 chr2:99771622 LIPT1;TSGA10 -0.81 -11.61 -0.54 2.3e-26 Chronic sinus infection; CRC cis rs9372498 0.505 rs9481789 chr6:118734320 A/C cg15382696 chr6:118971807 C6orf204 0.59 7.63 0.39 2.54e-13 Diastolic blood pressure; CRC cis rs853679 0.517 rs9393901 chr6:28136797 A/G cg12273811 chr6:28175739 NA 0.73 9.16 0.45 5.8e-18 Depression; CRC cis rs58688157 0.660 rs7117022 chr11:583787 T/C cg07212818 chr11:638076 DRD4 -0.45 -5.89 -0.31 9.33e-9 Systemic lupus erythematosus; CRC cis rs1448094 0.533 rs7307617 chr12:86151317 T/C cg19622623 chr12:86230825 RASSF9 0.39 5.95 0.31 6.81e-9 Major depressive disorder; CRC cis rs11971779 0.680 rs6954547 chr7:139054734 C/T cg23387468 chr7:139079360 LUC7L2 0.41 7.04 0.36 1.14e-11 Diisocyanate-induced asthma; CRC cis rs1552244 0.572 rs6797536 chr3:10168802 C/T cg16606324 chr3:10149918 C3orf24 -0.67 -8.03 -0.4 1.77e-14 Alzheimer's disease; CRC cis rs13191362 1.000 rs34594856 chr6:163051845 C/T cg21926612 chr6:163149169 PACRG;PARK2 0.98 12.7 0.57 2.33e-30 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs2243480 1.000 rs402418 chr7:65509469 G/A cg25985355 chr7:65971099 NA -0.54 -6.14 -0.32 2.35e-9 Diabetic kidney disease; CRC cis rs262150 0.704 rs2730236 chr7:158765543 C/T cg10570241 chr7:158785291 NA 0.42 7.11 0.36 7.32e-12 Facial morphology (factor 20); CRC cis rs7927771 0.524 rs11039329 chr11:47684908 A/G cg20307385 chr11:47447363 PSMC3 0.46 6.95 0.36 1.97e-11 Subjective well-being; CRC cis rs7607369 0.559 rs4674339 chr2:219659787 C/G cg02176678 chr2:219576539 TTLL4 -0.39 -6.35 -0.33 6.97e-10 Red blood cell count;Amyotrophic lateral sclerosis; CRC cis rs8072100 0.576 rs12948299 chr17:45403057 T/C cg25173405 chr17:45401733 C17orf57 -0.59 -8.9 -0.44 3.77e-17 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs2404602 0.583 rs12592501 chr15:76554790 C/A cg00316803 chr15:76480434 C15orf27 -0.38 -6.5 -0.34 2.94e-10 Blood metabolite levels; CRC cis rs709400 1.000 rs8018979 chr14:104109087 G/A cg24130564 chr14:104152367 KLC1 -0.45 -6.75 -0.35 6.75e-11 Body mass index; CRC cis rs11098499 0.644 rs6855918 chr4:120546299 C/T cg24375607 chr4:120327624 NA 0.49 7.67 0.39 1.91e-13 Corneal astigmatism; CRC cis rs12580194 0.593 rs61956292 chr12:55803346 T/C cg19537932 chr12:55886519 OR6C68 -0.72 -9.16 -0.45 5.6e-18 Cancer; CRC cis rs11212617 1.000 rs624366 chr11:108154097 C/G cg14761454 chr11:108092087 ATM;NPAT -0.4 -5.87 -0.31 1.08e-8 Response to metformin in type 2 diabetes (glycemic); CRC trans rs6550704 0.687 rs9865314 chr3:22634337 A/G cg14217534 chr12:49525474 TUBA1B -0.44 -6.37 -0.33 6.4e-10 Daytime sleep phenotypes; CRC cis rs7215564 0.822 rs2340769 chr17:78755271 C/T cg09596252 chr17:78655493 RPTOR -0.64 -5.8 -0.3 1.55e-8 Myopia (pathological); CRC cis rs4319547 1.000 rs7295397 chr12:123116209 C/T cg23029597 chr12:123009494 RSRC2 -0.63 -7.85 -0.4 5.97e-14 Body mass index; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg13952954 chr19:59066605 CHMP2A 0.41 6.22 0.32 1.55e-9 Intelligence (multi-trait analysis); CRC cis rs4566357 0.615 rs1800517 chr2:227915832 G/A cg11843606 chr2:227700838 RHBDD1 -0.44 -6.82 -0.35 4.37e-11 Coronary artery disease; CRC trans rs10983614 1.000 rs7867776 chr9:120072627 A/G cg03646922 chr17:4167316 ANKFY1 0.46 6.6 0.34 1.68e-10 Survival in pancreatic cancer; CRC cis rs7394190 1.000 rs10824026 chr10:75421208 A/G cg07699608 chr10:75541558 CHCHD1 0.52 6.14 0.32 2.37e-9 Incident atrial fibrillation; CRC trans rs7726839 0.574 rs72705014 chr5:619815 C/G cg11887960 chr12:57824829 NA 0.58 6.5 0.34 3.04e-10 Obesity-related traits; CRC cis rs10979 0.964 rs35826562 chr6:143898672 G/A cg25407410 chr6:143891975 LOC285740 -0.85 -13.66 -0.6 5.96e-34 Hypospadias; CRC cis rs9914988 0.943 rs11652272 chr17:27167973 C/G cg20469991 chr17:27169893 C17orf63 -0.61 -7.26 -0.37 2.88e-12 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs9522267 0.737 rs9515455 chr13:112239671 A/G cg10483660 chr13:112241077 NA 0.38 7.04 0.36 1.12e-11 Hepatitis; CRC cis rs1552244 1.000 rs7631678 chr3:10078816 T/G cg02579736 chr3:10068473 FANCD2;CIDECP 1.05 14.06 0.61 1.71e-35 Alzheimer's disease; CRC cis rs478304 0.654 rs1074156 chr11:65458169 G/T cg05805236 chr11:65401703 PCNXL3 -0.42 -6.7 -0.35 9.18e-11 Acne (severe); CRC cis rs853679 0.598 rs9380054 chr6:28067537 G/A cg25164649 chr6:28176230 NA 0.75 9.32 0.46 1.72e-18 Depression; CRC trans rs1005277 0.579 rs2505197 chr10:38393310 T/C cg17830980 chr10:43048298 ZNF37B -0.6 -9.96 -0.48 1.3e-20 Extrinsic epigenetic age acceleration; CRC cis rs754466 0.606 rs11002306 chr10:79591519 A/T cg17075019 chr10:79541650 NA -0.97 -17.79 -0.7 4.48e-50 Liver enzyme levels (gamma-glutamyl transferase); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg14511745 chr11:47573874 CUGBP1 0.44 6.48 0.34 3.3e-10 Intelligence (multi-trait analysis); CRC cis rs3204270 0.639 rs7216239 chr17:79660187 C/T cg18367735 chr17:79674897 NA 0.52 6.0 0.31 5.32e-9 Dental caries; CRC cis rs9443645 0.901 rs9448584 chr6:79572799 G/T cg05283184 chr6:79620031 NA -0.59 -9.43 -0.46 7.6e-19 Intelligence (multi-trait analysis); CRC trans rs2303319 0.504 rs62188988 chr2:162531068 T/C cg02396143 chr1:29063512 YTHDF2 -0.66 -5.96 -0.31 6.48e-9 Cognitive function; CRC trans rs7267979 1.000 rs6050544 chr20:25320228 T/A cg17903999 chr18:56338584 MALT1 0.41 6.69 0.35 9.69e-11 Liver enzyme levels (alkaline phosphatase); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg17482197 chr20:56285683 PMEPA1 0.38 6.44 0.33 4.32e-10 Liver disease severity in Alagille syndrome; CRC cis rs73206853 0.764 rs55913108 chr12:110816507 T/C cg12870014 chr12:110450643 ANKRD13A 0.84 10.0 0.48 1e-20 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC cis rs3008870 0.727 rs2755270 chr1:67474503 C/T cg08660285 chr1:67390436 MIER1;WDR78 0.54 7.7 0.39 1.62e-13 Lymphocyte percentage of white cells; CRC cis rs9911578 1.000 rs2531732 chr17:56548420 T/A cg05425664 chr17:57184151 TRIM37 0.52 8.27 0.41 3.34e-15 Intelligence (multi-trait analysis); CRC cis rs7772486 0.754 rs9373475 chr6:146126419 C/T cg13319975 chr6:146136371 FBXO30 -0.44 -6.48 -0.34 3.33e-10 Lobe attachment (rater-scored or self-reported); CRC trans rs1346081 0.786 rs1425645 chr4:68028175 C/T cg13240639 chr22:30162856 UCRC;ZMAT5 0.5 5.98 0.31 5.94e-9 Intelligence (multi-trait analysis); CRC cis rs1008375 1.000 rs56974987 chr4:17627856 G/A cg04450456 chr4:17643702 FAM184B 0.37 6.01 0.31 4.96e-9 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs2067615 0.524 rs7959062 chr12:107107334 G/T cg13491945 chr12:107078410 RFX4 0.36 6.13 0.32 2.47e-9 Heart rate; CRC cis rs6456156 0.526 rs3093025 chr6:167532731 A/G cg07513332 chr6:167530253 CCR6 -0.34 -5.92 -0.31 7.93e-9 Primary biliary cholangitis; CRC cis rs4076764 1.000 rs7540279 chr1:163429970 A/T cg24596788 chr1:163392923 NA -0.65 -10.21 -0.49 1.97e-21 Motion sickness; CRC trans rs1005277 0.579 rs2474575 chr10:38387901 C/T cg23533926 chr12:111358616 MYL2 -0.52 -7.84 -0.4 6.17e-14 Extrinsic epigenetic age acceleration; CRC cis rs7937682 0.881 rs4936678 chr11:111625085 C/T cg09085632 chr11:111637200 PPP2R1B 0.99 16.41 0.67 1.23e-44 Primary sclerosing cholangitis; CRC cis rs6952808 0.825 rs11761818 chr7:1935273 C/T cg02951883 chr7:2050386 MAD1L1 -0.69 -11.14 -0.52 1.12e-24 Bipolar disorder and schizophrenia; CRC cis rs2742540 0.503 rs982273 chr11:8906862 T/G cg12365402 chr11:9010492 NRIP3 -0.37 -6.07 -0.32 3.48e-9 Hematocrit; CRC cis rs4790333 0.531 rs2447107 chr17:2257864 A/G cg02569219 chr17:2266849 SGSM2 0.4 6.76 0.35 6.47e-11 Proinsulin levels; CRC cis rs2066819 1.000 rs78149779 chr12:56694817 A/G cg26714650 chr12:56694279 CS -1.41 -11.65 -0.54 1.7e-26 Psoriasis vulgaris; CRC cis rs2795502 0.938 rs2744085 chr10:43341976 C/T cg20628663 chr10:43360327 NA 0.68 10.65 0.51 6.05e-23 Blood protein levels; CRC cis rs870825 0.929 rs72689258 chr4:185590550 G/C cg07424746 chr4:185654737 MLF1IP -0.59 -5.82 -0.31 1.4e-8 Blood protein levels; CRC cis rs1572438 0.831 rs4960373 chr6:855764 A/C cg21062780 chr6:887772 NA -0.34 -5.62 -0.3 4.12e-8 Aging; CRC trans rs6703335 0.870 rs10803142 chr1:243598234 A/G cg03412310 chr8:55014671 LYPLA1 0.44 6.12 0.32 2.65e-9 Schizophrenia;Schizophrenia, schizoaffective disorder or bipolar disorder; CRC cis rs11212617 0.967 rs7942014 chr11:108326174 G/C cg01991180 chr11:108092276 ATM;NPAT 0.4 5.74 0.3 2.17e-8 Response to metformin in type 2 diabetes (glycemic); CRC cis rs3087591 0.919 rs9913470 chr17:29566575 A/G cg24425628 chr17:29625626 OMG;NF1 -0.87 -17.19 -0.69 1.02e-47 Hip circumference; CRC cis rs17042140 0.904 rs6540844 chr1:214680378 C/T cg16144317 chr1:214725524 PTPN14 0.52 6.79 0.35 5.19e-11 Plasma thyroid-stimulating hormone levels; CRC trans rs2303319 0.504 rs62188990 chr2:162540635 G/A cg10272801 chr16:14013773 ERCC4 -0.68 -6.01 -0.31 4.95e-9 Cognitive function; CRC cis rs12908161 0.920 rs12904605 chr15:85201419 T/C cg17507749 chr15:85114479 UBE2QP1 0.61 8.57 0.43 4.2e-16 Schizophrenia; CRC cis rs7208859 0.614 rs216412 chr17:28903394 A/G cg26176469 chr17:28951361 LRRC37B2 -0.51 -6.0 -0.31 5.26e-9 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs60871478 0.636 rs55663559 chr7:884057 G/A cg13798912 chr7:905769 UNC84A -0.63 -6.95 -0.36 1.99e-11 Cerebrospinal P-tau181p levels; CRC cis rs3093024 1.000 rs3093023 chr6:167534290 A/G cg07741184 chr6:167504864 NA -0.45 -7.97 -0.4 2.71e-14 Rheumatoid arthritis; CRC trans rs9903692 0.954 rs34750858 chr17:46132937 T/A cg13910583 chr8:56987998 RPS20 -0.44 -5.99 -0.31 5.63e-9 Pulse pressure; CRC cis rs10464366 0.544 rs4723824 chr7:39153698 T/C cg15212455 chr7:39170539 POU6F2 0.48 6.36 0.33 6.71e-10 IgG glycosylation; CRC cis rs2456568 0.709 rs12806128 chr11:93634972 C/T cg26875233 chr11:93583750 C11orf90 0.31 5.99 0.31 5.54e-9 Response to serotonin reuptake inhibitors in major depressive disorder; CRC cis rs9611565 0.506 rs7364221 chr22:41650190 C/A cg03806693 chr22:41940476 POLR3H -0.68 -9.29 -0.46 2.2e-18 Vitiligo; CRC cis rs736408 0.716 rs2239550 chr3:52822509 G/C cg11645453 chr3:52864694 ITIH4 0.36 6.14 0.32 2.32e-9 Bipolar disorder; CRC cis rs11628318 0.802 rs2277471 chr14:103024387 A/C cg08075719 chr14:103021372 NA 0.58 7.72 0.39 1.45e-13 Platelet count; CRC cis rs7940866 0.803 rs1865296 chr11:130882944 C/T cg12179176 chr11:130786555 SNX19 -0.59 -8.77 -0.44 1.01e-16 Schizophrenia; CRC cis rs875971 1.000 rs2087647 chr7:65593188 C/A cg11764359 chr7:65958608 NA -0.59 -9.45 -0.46 6.41e-19 Aortic root size; CRC cis rs7726839 0.540 rs72705097 chr5:655067 G/A cg16447950 chr5:562315 NA -0.77 -10.22 -0.49 1.75e-21 Obesity-related traits; CRC cis rs10504229 1.000 rs66936919 chr8:58172868 C/G cg02290350 chr8:58132656 NA -0.44 -6.39 -0.33 5.52e-10 Developmental language disorder (linguistic errors); CRC cis rs9311474 0.508 rs6786043 chr3:52604861 A/G cg08222913 chr3:52553049 STAB1 -0.34 -6.39 -0.33 5.78e-10 Electroencephalogram traits; CRC cis rs11212617 1.000 rs7946955 chr11:108284833 A/G cg14761454 chr11:108092087 ATM;NPAT 0.45 6.9 0.36 2.72e-11 Response to metformin in type 2 diabetes (glycemic); CRC cis rs1881797 1.000 rs7527856 chr1:247688139 C/T cg18198730 chr1:247681584 NA 0.52 8.16 0.41 7e-15 Acute lymphoblastic leukemia (childhood); CRC cis rs8010715 0.816 rs1134340 chr14:24594213 C/T cg23112188 chr14:24563095 PCK2 -0.35 -6.93 -0.36 2.21e-11 IgG glycosylation; CRC cis rs9549328 0.565 rs36145949 chr13:113616608 T/C cg20742385 chr13:113633654 MCF2L 0.55 9.39 0.46 1.01e-18 Systolic blood pressure; CRC cis rs2952156 0.883 rs12150603 chr17:37834715 G/A cg20243544 chr17:37824526 PNMT 0.55 8.83 0.44 6.13e-17 Asthma; CRC cis rs4727027 0.901 rs12671341 chr7:148805282 T/C cg12479418 chr7:148823350 ZNF425;ZNF398 0.45 5.99 0.31 5.44e-9 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC cis rs62244186 0.659 rs12489887 chr3:44547124 A/T cg18165381 chr3:44552316 NA -0.38 -5.64 -0.3 3.73e-8 Depressive symptoms; CRC cis rs2228479 0.850 rs62052212 chr16:89981960 G/A cg06558623 chr16:89946397 TCF25 1.04 10.53 0.5 1.57e-22 Skin colour saturation; CRC cis rs881375 1.000 rs10760121 chr9:123647915 G/T cg09419670 chr9:123605666 PSMD5;LOC253039 0.61 8.86 0.44 5.1e-17 Rheumatoid arthritis; CRC cis rs7258465 1.000 rs2303697 chr19:18546678 T/C cg01065977 chr19:18549689 ISYNA1 -0.41 -6.27 -0.33 1.15e-9 Breast cancer; CRC cis rs875971 0.662 rs448725 chr7:65514628 A/G cg12463550 chr7:65579703 CRCP 0.46 6.48 0.34 3.41e-10 Aortic root size; CRC cis rs6570726 0.818 rs9390338 chr6:145908265 A/G cg23711669 chr6:146136114 FBXO30 0.68 11.27 0.53 3.85e-25 Lobe attachment (rater-scored or self-reported); CRC cis rs2836974 0.897 rs12481860 chr21:40537836 T/A cg06238570 chr21:40685208 BRWD1 0.75 10.49 0.5 2.08e-22 Cognitive function; CRC cis rs9921222 0.521 rs78867928 chr16:368986 C/T cg12437481 chr16:420112 MRPL28 -0.65 -8.39 -0.42 1.47e-15 Bone mineral density (spine);Bone mineral density; CRC cis rs4631830 0.900 rs10763576 chr10:51538813 A/T cg16070123 chr10:51489643 NA -0.32 -5.61 -0.3 4.4e-8 Prostate-specific antigen levels; CRC cis rs4900538 0.821 rs12586673 chr14:102827643 C/T cg01761236 chr14:102990251 NA -0.3 -6.0 -0.31 5.28e-9 Mean corpuscular volume;Mean corpuscular hemoglobin; CRC cis rs75804782 0.641 rs72983834 chr2:239319895 G/A cg18131467 chr2:239335373 ASB1 -0.7 -6.06 -0.32 3.71e-9 Morning vs. evening chronotype;Chronotype; CRC cis rs780096 0.546 rs2293571 chr2:27729480 C/T cg24768116 chr2:27665128 KRTCAP3 -0.31 -6.92 -0.36 2.4e-11 Total body bone mineral density; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg19459508 chr3:160282885 KPNA4 0.44 6.1 0.32 3.04e-9 Anxiety disorder; CRC cis rs3617 0.599 rs12487379 chr3:52895785 G/A cg11645453 chr3:52864694 ITIH4 0.36 6.54 0.34 2.33e-10 Red blood cell count;Autism spectrum disorder or schizophrenia; CRC cis rs2688482 0.557 rs3103952 chr3:195522690 T/C cg11598736 chr3:195384522 SDHAP2 0.63 6.36 0.33 6.85e-10 Lung disease severity in cystic fibrosis; CRC cis rs9658691 0.790 rs4345878 chr10:90756511 T/C cg03111039 chr10:90751583 FAS;ACTA2 0.77 5.61 0.3 4.39e-8 Mosquito bite size; CRC cis rs1707322 0.717 rs10890345 chr1:46213927 C/T cg06784218 chr1:46089804 CCDC17 0.65 12.05 0.55 5.8e-28 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs597539 0.615 rs583182 chr11:68678634 C/T cg06028808 chr11:68637592 NA 0.39 6.31 0.33 9.04e-10 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs449789 0.524 rs4709299 chr6:159751033 C/T cg14500486 chr6:159655392 FNDC1 0.5 7.6 0.39 3.11e-13 Pulse pressure; CRC trans rs4714291 0.832 rs9471244 chr6:40092331 A/G cg02267698 chr19:7991119 CTXN1 0.5 6.88 0.35 2.97e-11 Strep throat; CRC trans rs360798 0.512 rs7562149 chr2:63008414 A/G cg05376469 chr2:102649931 NA 0.38 6.28 0.33 1.09e-9 Coronary artery disease; CRC trans rs7267979 1.000 rs2424710 chr20:25283886 C/G cg17903999 chr18:56338584 MALT1 -0.44 -7.2 -0.37 4.15e-12 Liver enzyme levels (alkaline phosphatase); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg09631309 chr2:37458880 CEBPZ;C2orf56 0.42 6.06 0.32 3.82e-9 Intelligence (multi-trait analysis); CRC cis rs910316 1.000 rs175512 chr14:75523382 T/C cg03030879 chr14:75389066 RPS6KL1 0.47 7.32 0.37 1.96e-12 Height; CRC cis rs6534441 0.697 rs58154336 chr4:125466363 C/T cg21609808 chr4:125404261 NA 0.41 5.64 0.3 3.68e-8 Major depressive disorder; CRC cis rs4713118 0.955 rs9368529 chr6:27684631 G/A cg02683197 chr6:28174875 NA 0.56 7.37 0.38 1.4e-12 Parkinson's disease; CRC cis rs2742417 1.000 rs1534876 chr3:45741257 G/T cg04837898 chr3:45731254 SACM1L -0.34 -5.67 -0.3 3.06e-8 Response to anti-depressant treatment in major depressive disorder; CRC cis rs17767392 0.881 rs17767686 chr14:72006744 C/T cg13720639 chr14:72061746 SIPA1L1 -0.56 -7.15 -0.37 5.62e-12 Mitral valve prolapse; CRC cis rs7666738 0.830 rs11932887 chr4:99072965 C/G cg05340658 chr4:99064831 C4orf37 0.59 9.2 0.45 4.27e-18 Colonoscopy-negative controls vs population controls; CRC cis rs10504229 0.679 rs17193048 chr8:58055392 G/A cg11062466 chr8:58055876 NA 0.55 6.76 0.35 6.4e-11 Developmental language disorder (linguistic errors); CRC cis rs6964587 0.967 rs12538325 chr7:91757479 A/G cg17063962 chr7:91808500 NA 0.78 12.41 0.56 2.98e-29 Breast cancer; CRC cis rs651907 0.535 rs11712309 chr3:101519097 T/C cg12386194 chr3:101231763 SENP7 0.52 7.45 0.38 8.46e-13 Colorectal cancer; CRC cis rs6502050 0.835 rs4789731 chr17:80145904 C/T cg25804541 chr17:80189381 SLC16A3 -0.3 -5.71 -0.3 2.57e-8 Life satisfaction; CRC trans rs1997103 1.000 rs6593237 chr7:55411015 T/C cg20935933 chr6:143382018 AIG1 0.51 6.68 0.35 1.02e-10 QRS interval (sulfonylurea treatment interaction); CRC cis rs6582630 0.533 rs11181379 chr12:38332381 C/T cg26384229 chr12:38710491 ALG10B 0.43 6.21 0.32 1.64e-9 Drug-induced liver injury (flucloxacillin); CRC cis rs7208859 0.673 rs9894876 chr17:29182020 G/A cg13385521 chr17:29058706 SUZ12P 0.69 8.02 0.4 1.81e-14 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs1799949 1.000 rs34059614 chr17:41303071 C/T cg25072359 chr17:41440525 NA 0.44 6.42 0.33 4.86e-10 Menopause (age at onset); CRC cis rs9517320 0.534 rs4771306 chr13:99143661 T/C cg20487152 chr13:99095054 FARP1 -0.47 -6.81 -0.35 4.68e-11 Longevity; CRC cis rs1862618 0.853 rs10461617 chr5:56104308 A/G cg22800045 chr5:56110881 MAP3K1 0.54 5.93 0.31 7.69e-9 Initial pursuit acceleration; CRC cis rs2013441 1.000 rs1992562 chr17:20218793 A/C cg13482628 chr17:19912719 NA -0.42 -6.15 -0.32 2.31e-9 Obesity-related traits; CRC cis rs9372498 0.536 rs1319988 chr6:118782379 G/A cg01339444 chr6:118972232 C6orf204 0.54 6.02 0.32 4.65e-9 Diastolic blood pressure; CRC cis rs9381040 0.610 rs6940356 chr6:41020360 C/T cg03644281 chr6:41068752 NFYA;LOC221442 -0.44 -6.37 -0.33 6.31e-10 Alzheimer's disease (late onset); CRC cis rs11098499 0.820 rs12503082 chr4:120284317 A/G cg24375607 chr4:120327624 NA 0.48 7.48 0.38 6.72e-13 Corneal astigmatism; CRC cis rs6951245 0.744 rs10265736 chr7:1172465 C/T cg24642844 chr7:1081250 C7orf50 -0.67 -8.47 -0.42 8.11e-16 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs13108904 0.935 rs2199956 chr4:1248919 A/G cg20887711 chr4:1340912 KIAA1530 0.45 6.41 0.33 5.04e-10 Obesity-related traits; CRC cis rs10256972 0.706 rs12701969 chr7:1121849 A/G cg03188948 chr7:1209495 NA 0.42 5.71 0.3 2.55e-8 Longevity;Endometriosis; CRC cis rs7591163 1.000 rs2056566 chr2:228713241 G/A cg08034379 chr2:228736324 WDR69 -0.53 -7.22 -0.37 3.59e-12 Blood pressure; CRC trans rs1656966 1.000 rs1656966 chr3:186466252 C/T cg15942382 chr10:98273924 TLL2 0.39 5.98 0.31 5.84e-9 Myopia (pathological); CRC cis rs1403694 1.000 rs2651640 chr3:186438393 G/A cg04611788 chr3:186434169 KNG1 -0.46 -7.02 -0.36 1.27e-11 Blood protein levels; CRC cis rs870825 0.616 rs7678849 chr4:185648868 T/C cg04058563 chr4:185651563 MLF1IP 0.72 9.3 0.46 2.04e-18 Blood protein levels; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg02757696 chr20:33104113 DYNLRB1 0.45 6.63 0.34 1.37e-10 Intelligence (multi-trait analysis); CRC cis rs10927875 0.615 rs10927886 chr1:16339313 C/G cg10494257 chr1:16342123 HSPB7 -0.45 -6.32 -0.33 8.5e-10 Dilated cardiomyopathy; CRC cis rs863345 0.604 rs10797021 chr1:158490341 T/C cg12129480 chr1:158549410 OR10X1 -0.3 -6.23 -0.32 1.44e-9 Pneumococcal bacteremia; CRC cis rs6662572 0.851 rs55654017 chr1:46249299 T/G cg08644498 chr1:46502608 NA 0.46 7.18 0.37 4.77e-12 Blood protein levels; CRC trans rs7873102 0.702 rs7028020 chr9:38007747 C/T cg06537201 chr12:58330115 NA -0.45 -6.74 -0.35 7.29e-11 Brain structure; CRC cis rs9648716 1.000 rs1267635 chr7:140491678 G/A cg10747023 chr7:140774559 NA 0.44 5.67 0.3 3.1e-8 Type 2 diabetes; CRC cis rs1401999 1.000 rs3805108 chr3:183691650 T/C cg01324343 chr3:183735012 ABCC5 0.75 13.52 0.6 1.98e-33 Anterior chamber depth; CRC cis rs3741404 0.609 rs641430 chr11:63869531 C/T cg18225595 chr11:63971243 STIP1 -0.41 -6.55 -0.34 2.16e-10 Platelet count; CRC cis rs6988636 1.000 rs58741168 chr8:124191852 G/A cg27053337 chr8:124217698 FAM83A 0.35 5.77 0.3 1.87e-8 Urinary uromodulin levels; CRC cis rs3087591 1.000 rs2051506 chr17:29699860 T/A cg24425628 chr17:29625626 OMG;NF1 -0.84 -16.32 -0.67 2.77e-44 Hip circumference; CRC cis rs35110281 0.591 rs162366 chr21:44935383 C/T cg01579765 chr21:45077557 HSF2BP 0.36 6.79 0.35 5.28e-11 Mean corpuscular volume; CRC cis rs2898681 0.519 rs73814886 chr4:53733251 C/T cg26260408 chr4:53727979 RASL11B 0.41 5.82 0.31 1.37e-8 Optic nerve measurement (cup area); CRC cis rs4664293 0.546 rs1991373 chr2:160516225 A/T cg08347373 chr2:160653686 CD302 0.39 6.58 0.34 1.91e-10 Monocyte percentage of white cells; CRC cis rs7113874 0.589 rs11041944 chr11:8500996 G/A cg02811074 chr11:8615871 STK33 0.37 6.24 0.33 1.33e-9 Body mass index in physically active individuals;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs727505 1.000 rs10271646 chr7:124549573 T/C cg23710748 chr7:124431027 NA -0.68 -12.15 -0.56 2.49e-28 Lewy body disease; CRC cis rs4711336 1.000 rs2296741 chr6:33659557 C/T cg14003231 chr6:33640908 ITPR3 0.5 7.98 0.4 2.51e-14 Height; CRC cis rs2180341 1.000 rs7756336 chr6:127650299 T/C cg27446573 chr6:127587934 RNF146 0.99 14.58 0.63 1.75e-37 Breast cancer; CRC trans rs473976 1.000 rs1943946 chr18:40414893 A/C cg09252331 chr1:15655927 FHAD1 -0.48 -6.19 -0.32 1.82e-9 Gut microbiome composition (summer); CRC cis rs12024301 0.557 rs11809046 chr1:183648131 C/A cg11505048 chr1:183622726 RGL1;APOBEC4 0.71 6.24 0.33 1.33e-9 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs7224685 0.501 rs781852 chr17:3953102 A/G cg10724054 chr17:3904396 NA -0.47 -7.74 -0.39 1.26e-13 Type 2 diabetes; CRC cis rs3018066 0.666 rs4521418 chr4:107029363 T/A cg01869342 chr4:106983673 TBCK 0.42 5.65 0.3 3.5e-8 Cancer; CRC cis rs10512697 1.000 rs34840936 chr5:3568755 G/C cg19473799 chr5:3511975 NA -0.76 -5.81 -0.31 1.44e-8 Immune response to smallpox vaccine (IL-6); CRC cis rs713477 0.935 rs4901567 chr14:55912698 C/T cg13175173 chr14:55914753 NA -0.48 -9.1 -0.45 8.71e-18 Pediatric bone mineral content (femoral neck); CRC cis rs4862750 0.914 rs10027250 chr4:187873460 T/C cg06074448 chr4:187884817 NA -0.6 -11.07 -0.52 2.06e-24 Lobe attachment (rater-scored or self-reported); CRC cis rs2204008 0.837 rs12146734 chr12:38237079 A/G cg26384229 chr12:38710491 ALG10B 0.68 9.08 0.45 9.92e-18 Bladder cancer; CRC cis rs11122272 0.735 rs2244986 chr1:231537452 C/T cg06096015 chr1:231504339 EGLN1 0.41 6.12 0.32 2.62e-9 Hemoglobin concentration; CRC cis rs4601821 0.858 rs7945132 chr11:113262473 A/T cg14159747 chr11:113255604 NA 0.52 9.61 0.47 2.02e-19 Alcoholic chronic pancreatitis; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg09060823 chr12:56862504 SPRYD4 0.48 6.17 0.32 2e-9 Thyroid stimulating hormone; CRC cis rs427943 0.750 rs7281416 chr21:46605839 T/C cg19498844 chr21:46707878 POFUT2;LOC642852 0.45 5.92 0.31 7.91e-9 Body mass index; CRC cis rs9309473 0.950 rs11689588 chr2:73773691 A/G cg20560298 chr2:73613845 ALMS1 -0.56 -6.38 -0.33 6.18e-10 Metabolite levels; CRC cis rs6743226 0.901 rs7592138 chr2:242218915 G/A cg10021735 chr2:242295487 FARP2 0.46 6.55 0.34 2.25e-10 Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI in non-smokers; CRC cis rs908922 0.676 rs3753451 chr1:152485227 T/G cg09873164 chr1:152488093 CRCT1 0.34 5.81 0.31 1.47e-8 Hair morphology; CRC cis rs4819052 0.851 rs2838843 chr21:46669284 T/C cg19498844 chr21:46707878 POFUT2;LOC642852 0.74 10.69 0.51 4.4e-23 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs4321325 0.733 rs111245735 chr2:127942522 A/C cg11380483 chr2:127933992 NA 0.62 7.24 0.37 3.27e-12 Protein C levels; CRC cis rs1707322 0.686 rs2152078 chr1:46055600 C/T cg06784218 chr1:46089804 CCDC17 -0.64 -11.73 -0.54 8.99e-27 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs9611565 0.592 rs9611612 chr22:41961189 T/C cg03806693 chr22:41940476 POLR3H -0.9 -11.42 -0.53 1.15e-25 Vitiligo; CRC cis rs4073582 0.595 rs801741 chr11:65917084 A/G cg14036092 chr11:66035641 RAB1B 0.55 8.81 0.44 7.18e-17 Gout; CRC cis rs2228479 0.702 rs17233176 chr16:89832751 G/C cg06558623 chr16:89946397 TCF25 1.13 10.49 0.5 2.13e-22 Skin colour saturation; CRC cis rs10256972 0.758 rs9801444 chr7:1080444 A/C cg04025307 chr7:1156635 C7orf50 -0.51 -7.89 -0.4 4.47e-14 Longevity;Endometriosis; CRC cis rs4481887 0.927 rs4427440 chr1:248480337 T/A cg00666640 chr1:248458726 OR2T12 0.49 8.27 0.41 3.45e-15 Common traits (Other); CRC cis rs4920343 0.698 rs851121 chr1:19087765 C/T cg19637330 chr1:19110922 NA 0.39 5.82 0.31 1.39e-8 Knee osteoarthritis; CRC cis rs1707322 1.000 rs7532204 chr1:46485075 C/G cg06784218 chr1:46089804 CCDC17 -0.52 -9.42 -0.46 8.2e-19 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg05889321 chr10:97416837 ALDH18A1 0.53 7.38 0.38 1.31e-12 Thyroid stimulating hormone; CRC cis rs6502050 0.799 rs6502088 chr17:80169484 C/T cg09264619 chr17:80180166 NA -0.37 -6.17 -0.32 1.97e-9 Life satisfaction; CRC cis rs2115630 1.000 rs56074163 chr15:85351332 C/T cg09876464 chr15:85330779 ZNF592 0.46 7.88 0.4 4.83e-14 P wave terminal force; CRC trans rs4276421 0.837 rs7706140 chr5:45474814 A/C cg04793272 chr11:119020941 ABCG4 -0.4 -6.51 -0.34 2.82e-10 P wave duration; CRC cis rs921968 0.541 rs7603816 chr2:219396255 C/T cg02176678 chr2:219576539 TTLL4 -0.58 -9.2 -0.45 4.09e-18 Mean corpuscular hemoglobin concentration; CRC cis rs9399135 0.967 rs13191501 chr6:135366880 T/C cg24558204 chr6:135376177 HBS1L 0.49 7.72 0.39 1.41e-13 Red blood cell count; CRC cis rs11148252 0.875 rs9568728 chr13:52946593 C/T cg12458913 chr13:53173898 NA 0.5 7.97 0.4 2.57e-14 Lewy body disease; CRC cis rs7493 0.950 rs7785846 chr7:95033841 C/T cg20119798 chr7:94954144 PON1 -0.48 -6.18 -0.32 1.89e-9 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs7618915 0.501 rs2336149 chr3:52692124 G/A cg15147215 chr3:52552868 STAB1 -0.64 -11.07 -0.52 1.98e-24 Bipolar disorder; CRC cis rs4478858 0.684 rs12121165 chr1:31725542 G/A cg00250761 chr1:31883323 NA -0.45 -8.81 -0.44 7.53e-17 Alcohol dependence; CRC cis rs11123170 0.529 rs1015755 chr2:113968307 G/A cg21550016 chr2:113992930 PAX8;LOC440839;LOC654433 0.53 6.2 0.32 1.67e-9 Renal function-related traits (BUN); CRC cis rs6424115 0.800 rs2229583 chr1:24200983 C/T cg10978503 chr1:24200527 CNR2 0.61 11.11 0.52 1.42e-24 Immature fraction of reticulocytes; CRC cis rs881375 0.967 rs7034492 chr9:123687211 G/A cg09586646 chr9:123605570 PSMD5;LOC253039 0.47 6.53 0.34 2.5e-10 Rheumatoid arthritis; CRC cis rs2487048 0.761 rs1800976 chr9:107690709 C/G cg14470647 chr9:107690075 ABCA1 -0.38 -5.7 -0.3 2.62e-8 Intraocular pressure; CRC cis rs1046896 0.562 rs2380172 chr17:80887719 C/A cg19046167 chr17:80928561 B3GNTL1 0.49 6.85 0.35 3.71e-11 Glycated hemoglobin levels; CRC cis rs644799 0.622 rs1255167 chr11:95500213 C/T cg25622487 chr11:95524042 FAM76B;CEP57 0.6 9.32 0.46 1.77e-18 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs4713675 0.584 rs7759668 chr6:33670406 C/T cg14003231 chr6:33640908 ITPR3 -0.5 -8.06 -0.41 1.45e-14 Plateletcrit; CRC cis rs7618915 0.547 rs11130317 chr3:52731483 C/T cg18099408 chr3:52552593 STAB1 -0.44 -7.19 -0.37 4.3e-12 Bipolar disorder; CRC cis rs7264396 0.635 rs6060685 chr20:34512023 G/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.61 -10.13 -0.49 3.5e-21 Total cholesterol levels; CRC cis rs8060686 0.546 rs8047343 chr16:68143745 G/A cg26727032 chr16:67993705 SLC12A4 -0.62 -9.95 -0.48 1.5e-20 HDL cholesterol;Metabolic syndrome; CRC cis rs9322193 0.923 rs9767652 chr6:150055638 A/T cg07701084 chr6:150067640 NUP43 0.57 8.11 0.41 9.94e-15 Lung cancer; CRC cis rs1949733 0.656 rs2688224 chr4:8404700 C/G cg11789530 chr4:8429930 ACOX3 0.75 11.06 0.52 2.1e-24 Response to antineoplastic agents; CRC cis rs910316 0.967 rs10246 chr14:75544470 T/A cg03030879 chr14:75389066 RPS6KL1 -0.45 -6.95 -0.36 1.95e-11 Height; CRC cis rs1552244 1.000 rs7631678 chr3:10078816 T/G cg18598329 chr3:10140678 FANCD2;C3orf24 -0.89 -11.87 -0.55 2.69e-27 Alzheimer's disease; CRC cis rs832540 0.656 rs6862118 chr5:56106474 G/A cg03609598 chr5:56110824 MAP3K1 -0.45 -6.13 -0.32 2.57e-9 Coronary artery disease; CRC cis rs514406 0.644 rs1855127 chr1:53199594 A/G cg24675658 chr1:53192096 ZYG11B 0.73 11.96 0.55 1.28e-27 Monocyte count; CRC cis rs1799949 1.000 rs8176269 chr17:41213626 G/T cg19454999 chr17:41278357 BRCA1;NBR2 0.53 8.15 0.41 7.88e-15 Menopause (age at onset); CRC cis rs10155981 0.510 rs4722158 chr7:22584183 G/A cg05062323 chr7:22590069 NA -0.61 -5.72 -0.3 2.42e-8 Bilirubin levels; CRC cis rs921968 0.643 rs3770218 chr2:219525335 C/T cg02176678 chr2:219576539 TTLL4 0.49 7.9 0.4 4.33e-14 Mean corpuscular hemoglobin concentration; CRC trans rs1005277 0.579 rs1780115 chr10:38524773 C/T cg11292332 chr7:45801988 SEPT13 -0.39 -7.05 -0.36 1.05e-11 Extrinsic epigenetic age acceleration; CRC cis rs6570726 0.738 rs6925594 chr6:145898454 T/C cg13319975 chr6:146136371 FBXO30 -0.42 -6.19 -0.32 1.75e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs7772486 0.641 rs67882056 chr6:146416301 T/C cg05347473 chr6:146136440 FBXO30 0.45 6.52 0.34 2.6200000000000003e-10 Lobe attachment (rater-scored or self-reported); CRC cis rs10416265 0.528 rs7249097 chr19:33589144 T/C cg17764715 chr19:33622953 WDR88 0.45 6.48 0.34 3.38e-10 Bone properties (heel); CRC cis rs68170813 0.559 rs3779498 chr7:106923158 C/G cg02696742 chr7:106810147 HBP1 -0.6 -6.65 -0.34 1.25e-10 Coronary artery disease; CRC cis rs910316 0.874 rs61980828 chr14:75630378 G/A cg08847533 chr14:75593920 NEK9 -0.96 -18.42 -0.71 1.43e-52 Height; CRC cis rs11719291 0.833 rs11709246 chr3:48859498 G/A cg07636037 chr3:49044803 WDR6 -0.82 -6.75 -0.35 6.8e-11 Cognitive function; CRC cis rs478304 0.593 rs12576766 chr11:65488556 C/T cg05805236 chr11:65401703 PCNXL3 -0.39 -6.05 -0.32 3.86e-9 Acne (severe); CRC cis rs68170813 0.559 rs76299183 chr7:106904859 A/G cg02696742 chr7:106810147 HBP1 -0.63 -7.01 -0.36 1.32e-11 Coronary artery disease; CRC cis rs4285028 0.699 rs12637968 chr3:121599976 C/T cg20356878 chr3:121714668 ILDR1 -0.48 -6.58 -0.34 1.91e-10 Multiple sclerosis; CRC trans rs7615952 0.866 rs13063119 chr3:125643847 G/A cg00769240 chr8:12517080 NA -0.57 -6.72 -0.35 8.17e-11 Blood pressure (smoking interaction); CRC cis rs6840360 0.692 rs1838043 chr4:152411462 T/C cg09659197 chr4:152720779 NA 0.43 8.33 0.42 2.21e-15 Intelligence (multi-trait analysis); CRC cis rs3741151 0.686 rs60860405 chr11:73248673 A/C cg17517138 chr11:73019481 ARHGEF17 0.55 5.86 0.31 1.1e-8 GIP levels in response to oral glucose tolerance test (120 minutes); CRC cis rs7647973 0.516 rs4955418 chr3:49200627 A/G cg07636037 chr3:49044803 WDR6 0.84 12.68 0.57 2.92e-30 Menarche (age at onset); CRC cis rs9287719 0.934 rs6432110 chr2:10738018 T/A cg00105475 chr2:10696890 NA 0.45 7.3 0.37 2.19e-12 Prostate cancer; CRC cis rs11583043 0.918 rs6577216 chr1:101409972 C/A cg16556008 chr1:101360663 SLC30A7;EXTL2 0.57 8.01 0.4 1.94e-14 Ulcerative colitis;Inflammatory bowel disease; CRC cis rs524281 0.861 rs11607393 chr11:65875149 C/A cg16950941 chr11:66035639 RAB1B -0.6 -7.35 -0.38 1.59e-12 Electroencephalogram traits; CRC cis rs910316 1.000 rs175426 chr14:75624134 C/T cg08847533 chr14:75593920 NEK9 -0.9 -16.46 -0.67 7.75e-45 Height; CRC cis rs875971 0.789 rs10260426 chr7:65736042 G/T cg00343986 chr7:65444356 GUSB -0.45 -6.2 -0.32 1.72e-9 Aortic root size; CRC cis rs7666738 0.680 rs11097613 chr4:99079991 G/T cg05340658 chr4:99064831 C4orf37 0.53 7.97 0.4 2.65e-14 Colonoscopy-negative controls vs population controls; CRC cis rs2952156 0.959 rs2941503 chr17:37828745 A/G cg00129232 chr17:37814104 STARD3 -0.68 -11.28 -0.53 3.66e-25 Asthma; CRC cis rs2019137 0.836 rs4848318 chr2:113953952 T/C cg07772999 chr2:113993052 PAX8;LOC440839;LOC654433 -0.46 -6.5 -0.34 2.97e-10 Lymphocyte counts; CRC cis rs250677 0.687 rs2963485 chr5:148452043 A/G cg23229984 chr5:148520753 ABLIM3 -0.43 -5.84 -0.31 1.29e-8 Breast cancer; CRC cis rs9303280 0.806 rs12232497 chr17:38040119 T/C cg00129232 chr17:37814104 STARD3 -0.46 -7.42 -0.38 1e-12 Self-reported allergy; CRC cis rs7917772 0.604 rs7908249 chr10:104373300 A/G cg11453585 chr10:104263688 ACTR1A;SUFU 0.82 15.13 0.64 1.23e-39 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC cis rs10256972 0.553 rs4236381 chr7:1165723 A/C cg23708337 chr7:1209742 NA 0.45 6.56 0.34 2.05e-10 Longevity;Endometriosis; CRC cis rs4665809 0.590 rs4665313 chr2:26415897 A/G cg08067268 chr2:26466485 HADHB;HADHA -0.67 -8.62 -0.43 2.95e-16 Gut microbiome composition (summer); CRC cis rs11645898 0.872 rs7206422 chr16:72152652 C/T cg14768367 chr16:72042858 DHODH -0.56 -6.06 -0.32 3.72e-9 Blood protein levels; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg01511104 chr20:5107621 CDS2;PCNA 0.43 5.98 0.31 5.71e-9 Response to antipsychotic treatment; CRC cis rs28386778 0.897 rs2665797 chr17:61922485 C/G cg22520471 chr17:61851767 DDX42;CCDC47 -0.74 -11.7 -0.54 1.13e-26 Prudent dietary pattern; CRC cis rs6860806 0.507 rs169256 chr5:131688533 A/G cg02033258 chr5:131593261 PDLIM4 0.41 6.16 0.32 2.18e-9 Breast cancer; CRC cis rs7216064 1.000 rs7209675 chr17:65831258 A/T cg12091567 chr17:66097778 LOC651250 -0.63 -7.94 -0.4 3.28e-14 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CRC cis rs6586163 0.843 rs7069061 chr10:90754909 A/G cg13456138 chr10:90753195 FAS -0.43 -6.63 -0.34 1.38e-10 Chronic lymphocytic leukemia; CRC cis rs1577917 0.958 rs67024565 chr6:86553997 C/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.59 -7.31 -0.37 2.03e-12 Response to antipsychotic treatment; CRC cis rs67311347 0.955 rs73078170 chr3:40483947 C/T cg09455208 chr3:40491958 NA 0.5 9.74 0.47 7.45e-20 Renal cell carcinoma; CRC cis rs730566 1.000 rs4858819 chr3:48478088 C/T cg07636037 chr3:49044803 WDR6 -0.52 -5.99 -0.31 5.4e-9 Prion diseases; CRC trans rs4650994 0.544 rs6675811 chr1:178499068 T/A cg05059571 chr16:84539110 KIAA1609 -0.56 -7.81 -0.4 7.49e-14 HDL cholesterol levels;HDL cholesterol; CRC cis rs898097 0.812 rs55794221 chr17:80849003 G/A cg19046167 chr17:80928561 B3GNTL1 -0.42 -6.47 -0.34 3.47e-10 Breast cancer; CRC cis rs4889855 0.556 rs74003969 chr17:78526212 C/T cg16591659 chr17:78472290 NA 0.39 5.74 0.3 2.1e-8 Fractional excretion of uric acid; CRC cis rs10493773 0.649 rs17398321 chr1:86084493 A/G cg17807903 chr1:86174739 ZNHIT6 -0.43 -7.97 -0.4 2.7e-14 Urate levels in overweight individuals; CRC cis rs3751196 1.000 rs12425283 chr12:104176292 T/C cg02344784 chr12:104178138 NT5DC3 0.73 7.73 0.39 1.3e-13 Sense of smell; CRC cis rs1862618 0.620 rs2591967 chr5:56233551 C/G cg20203395 chr5:56204925 C5orf35 0.58 7.81 0.4 7.96e-14 Initial pursuit acceleration; CRC trans rs2553218 0.690 rs8032415 chr15:54851945 A/G cg08834152 chr2:73441314 SMYD5 0.49 6.47 0.34 3.5e-10 Immune response to smallpox vaccine (IL-6); CRC cis rs6500602 0.627 rs9938228 chr16:4530597 T/C cg14951292 chr16:4525986 HMOX2;NMRAL1 0.72 10.17 0.49 2.59e-21 Schizophrenia; CRC cis rs4523957 0.890 rs216222 chr17:2155701 T/A cg16513277 chr17:2031491 SMG6 0.52 8.54 0.43 5.06e-16 Autism spectrum disorder or schizophrenia;Schizophrenia; CRC cis rs7666738 0.830 rs13124127 chr4:98990729 G/A cg05340658 chr4:99064831 C4orf37 0.59 8.94 0.44 2.77e-17 Colonoscopy-negative controls vs population controls; CRC cis rs28386778 0.787 rs2665827 chr17:61961350 G/C cg23090583 chr17:61904693 PSMC5;FTSJ3 1.04 18.81 0.72 4.07e-54 Prudent dietary pattern; CRC cis rs9399137 0.507 rs4594969 chr6:135285586 A/T cg22676075 chr6:135203613 NA 0.58 8.64 0.43 2.43e-16 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; CRC cis rs240764 0.578 rs6925065 chr6:101178856 C/T cg09795085 chr6:101329169 ASCC3 0.45 6.27 0.33 1.14e-9 Neuroticism; CRC cis rs6964587 0.967 rs10246036 chr7:91558523 G/A cg17063962 chr7:91808500 NA -0.77 -13.0 -0.58 1.76e-31 Breast cancer; CRC cis rs863345 0.604 rs2317970 chr1:158504770 T/C cg12129480 chr1:158549410 OR10X1 -0.3 -6.27 -0.33 1.12e-9 Pneumococcal bacteremia; CRC cis rs1129187 0.967 rs3805951 chr6:42937176 C/A cg21280719 chr6:42927975 GNMT -0.44 -9.57 -0.47 2.56e-19 Alzheimer's disease in APOE e4+ carriers; CRC cis rs13217239 0.646 rs10946898 chr6:27003884 T/C cg05192639 chr6:26864778 GUSBL1 0.32 6.07 0.32 3.45e-9 Schizophrenia; CRC cis rs9443645 0.901 rs13191068 chr6:79714867 T/C cg05283184 chr6:79620031 NA -0.61 -9.73 -0.47 7.98e-20 Intelligence (multi-trait analysis); CRC cis rs367943 1.000 rs460079 chr5:112800525 G/A cg12552261 chr5:112820674 MCC -0.5 -7.6 -0.39 3.13e-13 Type 2 diabetes; CRC trans rs1656966 1.000 rs1656966 chr3:186466252 C/T cg10245697 chr20:3869582 PANK2 0.4 6.15 0.32 2.26e-9 Myopia (pathological); CRC cis rs6604026 0.630 rs2391177 chr1:93353943 G/A cg17283838 chr1:93427260 FAM69A -0.44 -5.91 -0.31 8.61e-9 Multiple sclerosis; CRC cis rs1005277 0.540 rs11011351 chr10:38030525 A/G cg00409905 chr10:38381863 ZNF37A -0.64 -10.63 -0.51 6.96e-23 Extrinsic epigenetic age acceleration; CRC cis rs11098499 0.863 rs9884402 chr4:120489982 A/G cg09307838 chr4:120376055 NA 0.68 10.09 0.49 4.78e-21 Corneal astigmatism; CRC cis rs72615157 0.634 rs74742883 chr7:99785765 T/G cg19337854 chr7:99768885 GPC2 0.48 6.42 0.33 4.73e-10 Lung function (FEV1/FVC); CRC cis rs6499255 1.000 rs4985523 chr16:69797192 T/A cg15192750 chr16:69999425 NA 0.57 7.49 0.38 6.52e-13 IgE levels; CRC cis rs9462027 0.588 rs13215181 chr6:34759881 A/G cg07306190 chr6:34760872 UHRF1BP1 -0.35 -6.32 -0.33 8.56e-10 Systemic lupus erythematosus; CRC cis rs3741404 0.825 rs60452247 chr11:63981507 G/A cg06219103 chr11:63990595 FERMT3 -0.38 -5.7 -0.3 2.74e-8 Platelet count; CRC cis rs2836974 0.897 rs8133146 chr21:40614298 T/C cg11890956 chr21:40555474 PSMG1 1.09 18.65 0.72 1.87e-53 Cognitive function; CRC cis rs7552404 0.696 rs1417405 chr1:76457797 T/C cg22875332 chr1:76189707 ACADM 0.62 7.53 0.38 5.05e-13 Blood metabolite levels;Acylcarnitine levels; CRC cis rs1862618 0.671 rs2255726 chr5:56243128 T/C cg18230493 chr5:56204884 C5orf35 0.6 8.91 0.44 3.62e-17 Initial pursuit acceleration; CRC cis rs7246657 0.941 rs67293224 chr19:37803248 C/T cg23950597 chr19:37808831 NA -0.52 -6.05 -0.32 3.92e-9 Coronary artery calcification; CRC cis rs6942756 0.758 rs13226649 chr7:128977598 C/T cg02491457 chr7:128862824 NA -0.64 -8.73 -0.43 1.33e-16 White matter hyperintensity burden; CRC cis rs10791097 0.720 rs6590515 chr11:130733365 A/G cg12179176 chr11:130786555 SNX19 -0.74 -11.47 -0.53 7.78e-26 Autism spectrum disorder or schizophrenia;Schizophrenia; CRC trans rs2727020 0.521 rs7946190 chr11:49521964 T/A cg03929089 chr4:120376271 NA 0.76 10.1 0.49 4.37e-21 Coronary artery disease; CRC cis rs17023223 0.537 rs2645305 chr1:119561365 A/G cg05756136 chr1:119680316 WARS2 -0.53 -7.21 -0.37 3.97e-12 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for BMI in active individuals; CRC cis rs5417 0.662 rs8067500 chr17:7172631 A/G cg13729891 chr17:7108468 DLG4 -0.41 -6.03 -0.32 4.52e-9 Diastolic blood pressure; CRC cis rs7512552 0.839 rs1260386 chr1:150369622 G/T cg15654264 chr1:150340011 RPRD2 0.59 8.65 0.43 2.26e-16 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); CRC cis rs7264396 0.563 rs61191623 chr20:34219987 A/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.46 -5.8 -0.3 1.58e-8 Total cholesterol levels; CRC cis rs6951245 1.000 rs28399710 chr7:1070631 G/T cg18402987 chr7:1209562 NA 0.64 6.77 0.35 6.03e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs1862618 0.613 rs252889 chr5:56227069 C/A cg03609598 chr5:56110824 MAP3K1 -0.59 -7.91 -0.4 3.82e-14 Initial pursuit acceleration; CRC cis rs10489525 0.550 rs6659415 chr1:115632211 C/T cg01522456 chr1:115632236 TSPAN2 0.67 9.98 0.48 1.13e-20 Autism; CRC cis rs7591163 0.883 rs16824023 chr2:228720877 G/A cg23807890 chr2:228736357 WDR69 -0.46 -6.68 -0.35 1.02e-10 Blood pressure; CRC cis rs7953508 0.741 rs1498707 chr12:93997128 G/A cg18151635 chr12:93972918 NA -0.52 -7.66 -0.39 2.08e-13 Pubertal anthropometrics; CRC cis rs11608355 0.552 rs2304549 chr12:109794875 A/G cg19025524 chr12:109796872 NA -0.61 -10.02 -0.48 8.4e-21 Neuroticism; CRC cis rs728616 0.867 rs56271768 chr10:81837051 T/G cg05935833 chr10:81318306 SFTPA2 -0.51 -6.15 -0.32 2.24e-9 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs2652822 0.901 rs4775622 chr15:63408179 A/C cg02713581 chr15:63449717 RPS27L 0.41 5.98 0.31 5.81e-9 Metabolic traits; CRC cis rs7552404 0.960 rs12134854 chr1:76137606 A/G cg03433033 chr1:76189801 ACADM 0.76 10.73 0.51 3.25e-23 Blood metabolite levels;Acylcarnitine levels; CRC cis rs6728302 0.557 rs2741321 chr2:233280239 A/G cg14418609 chr2:233286870 NA 0.7 6.5 0.34 2.93e-10 Height; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg21482170 chr19:6737889 GPR108 0.48 6.74 0.35 6.95e-11 Response to antipsychotic treatment; CRC cis rs12188164 0.686 rs72711369 chr5:420517 C/T cg26850624 chr5:429559 AHRR -0.77 -12.39 -0.56 3.3600000000000003e-29 Cystic fibrosis severity; CRC cis rs10489202 0.608 rs10800334 chr1:168075613 T/C cg24449463 chr1:168025552 DCAF6 -0.53 -7.28 -0.37 2.48e-12 Schizophrenia; CRC cis rs992157 0.965 rs13419763 chr2:219134950 C/T cg04731861 chr2:219085781 ARPC2 -0.27 -5.83 -0.31 1.3e-8 Colorectal cancer; CRC cis rs17401966 0.522 rs10492969 chr1:10286358 T/C cg19773385 chr1:10388646 KIF1B -0.48 -7.46 -0.38 7.55e-13 Hepatocellular carcinoma; CRC cis rs61160187 0.582 rs12654306 chr5:60184856 A/C cg16298547 chr5:60138761 ELOVL7 -0.28 -5.93 -0.31 7.59e-9 Educational attainment (years of education);Educational attainment (college completion); CRC cis rs17376456 0.825 rs28534784 chr5:93063332 C/A cg25358565 chr5:93447407 FAM172A 0.98 9.97 0.48 1.28e-20 Diabetic retinopathy; CRC cis rs780096 0.526 rs780102 chr2:27659491 T/C cg27432699 chr2:27873401 GPN1 -0.51 -7.82 -0.4 7.11e-14 Total body bone mineral density; CRC cis rs9814567 0.896 rs13089566 chr3:134349710 G/C cg06109529 chr3:134205091 CEP63;ANAPC13 0.68 9.79 0.48 4.84e-20 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC trans rs13128441 0.593 rs7672067 chr4:5154673 G/A cg24266670 chr11:115630629 NA -0.4 -5.97 -0.31 6.31e-9 Celiac disease; CRC cis rs13108904 0.870 rs12642797 chr4:1245990 G/A cg19318889 chr4:1322082 MAEA 0.39 5.69 0.3 2.86e-8 Obesity-related traits; CRC cis rs10791323 0.720 rs2851117 chr11:133705905 A/G cg15485101 chr11:133734466 NA -0.39 -7.03 -0.36 1.22e-11 Childhood ear infection; CRC cis rs6860806 0.695 rs6867282 chr5:131583120 G/C cg02033258 chr5:131593261 PDLIM4 0.41 7.74 0.39 1.26e-13 Breast cancer; CRC cis rs11764590 0.694 rs10241537 chr7:2083358 A/G cg14004847 chr7:1930337 MAD1L1 -0.45 -6.12 -0.32 2.7e-9 Neuroticism; CRC cis rs2806561 0.514 rs7414010 chr1:23543929 T/C cg24466277 chr1:23519622 HTR1D -0.44 -5.93 -0.31 7.77e-9 Height; CRC cis rs7618915 0.547 rs13069481 chr3:52666866 C/T cg15147215 chr3:52552868 STAB1 -0.62 -10.31 -0.49 8.6e-22 Bipolar disorder; CRC cis rs2013441 0.670 rs12937327 chr17:19978984 C/T cg13482628 chr17:19912719 NA 0.43 6.06 0.32 3.81e-9 Obesity-related traits; CRC cis rs7264396 0.887 rs2236159 chr20:34102189 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.38 -6.45 -0.34 3.98e-10 Total cholesterol levels; CRC cis rs634534 0.622 rs624273 chr11:65712413 A/G cg26695010 chr11:65641043 EFEMP2 -0.42 -6.25 -0.33 1.25e-9 Sum eosinophil basophil counts;Eosinophil counts; CRC cis rs11098499 0.909 rs71614422 chr4:120359340 G/A cg09307838 chr4:120376055 NA 0.71 11.06 0.52 2.21e-24 Corneal astigmatism; CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg09685351 chr22:45148319 ARHGAP8;PRR5-ARHGAP8 -0.43 -6.19 -0.32 1.79e-9 Diisocyanate-induced asthma; CRC cis rs7811142 0.943 rs10241492 chr7:99994813 A/G cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.74 9.96 0.48 1.34e-20 Platelet count; CRC cis rs4243830 0.850 rs4908912 chr1:6599558 A/C cg15205204 chr1:6545172 PLEKHG5 0.41 5.87 0.31 1.04e-8 Body mass index; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg25443968 chr17:21118207 TMEM11 0.46 6.16 0.32 2.17e-9 Thyroid stimulating hormone; CRC cis rs4969178 0.832 rs4969185 chr17:76398157 G/C cg20026190 chr17:76395443 PGS1 0.39 5.94 0.31 7.3e-9 HDL cholesterol levels; CRC cis rs7481584 0.603 rs399467 chr11:3072348 G/A cg25174290 chr11:3078921 CARS -0.43 -5.91 -0.31 8.4e-9 Calcium levels; CRC cis rs6988985 0.728 rs1114761 chr8:143928956 C/T cg10324643 chr8:143916377 GML -0.38 -6.33 -0.33 7.97e-10 Plasma androstenedione levels in resected early stage-receptor positive breast cancer; CRC cis rs4664293 0.836 rs13016015 chr2:160646529 A/G cg08347373 chr2:160653686 CD302 -0.47 -7.5 -0.38 6.09e-13 Monocyte percentage of white cells; CRC cis rs10504229 1.000 rs75037501 chr8:58170136 T/G cg01721255 chr8:58191610 C8orf71 0.49 6.17 0.32 2e-9 Developmental language disorder (linguistic errors); CRC cis rs9938149 0.706 rs6540220 chr16:88315515 G/C cg05435882 chr16:88311214 NA -0.43 -5.74 -0.3 2.21e-8 Corneal structure;Central corneal thickness; CRC cis rs2072510 0.569 rs7134860 chr12:96390358 C/A cg22491680 chr12:96389547 HAL -0.5 -6.16 -0.32 2.16e-9 Metabolite levels (small molecules and protein measures); CRC cis rs6502050 0.835 rs4789754 chr17:80091941 C/T cg22110888 chr17:80059540 CCDC57 0.41 6.41 0.33 5.17e-10 Life satisfaction; CRC cis rs72781680 1.000 rs72796327 chr2:24140372 T/C cg08917208 chr2:24149416 ATAD2B 1.03 10.24 0.49 1.55e-21 Lymphocyte counts; CRC cis rs2013441 0.613 rs9901125 chr17:20008929 A/G cg13482628 chr17:19912719 NA 0.38 5.82 0.31 1.37e-8 Obesity-related traits; CRC cis rs7208859 0.673 rs9915139 chr17:29158515 A/G cg14008862 chr17:28927542 LRRC37B2 0.53 5.85 0.31 1.16e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs868943 0.512 rs10456903 chr6:116541384 A/G cg15226275 chr6:116381976 FRK 0.26 6.05 0.32 3.88e-9 Total cholesterol levels; CRC trans rs1005277 0.579 rs1780139 chr10:38503018 C/T cg11292332 chr7:45801988 SEPT13 -0.38 -7.02 -0.36 1.26e-11 Extrinsic epigenetic age acceleration; CRC cis rs6460942 0.591 rs7804805 chr7:12332066 C/G cg20607287 chr7:12443886 VWDE -0.56 -6.15 -0.32 2.21e-9 Coronary artery disease; CRC cis rs6460942 1.000 rs75333414 chr7:12303829 T/A cg06484146 chr7:12443880 VWDE -0.66 -6.95 -0.36 1.98e-11 Coronary artery disease; CRC cis rs344364 0.511 rs2982453 chr16:1949520 G/A cg14074117 chr16:1909714 C16orf73 0.41 5.66 0.3 3.28e-8 Glomerular filtration rate in chronic kidney disease; CRC cis rs4713118 0.869 rs9348775 chr6:27695329 C/T cg08798685 chr6:27730294 NA -0.43 -6.23 -0.32 1.46e-9 Parkinson's disease; CRC cis rs12586317 0.547 rs2254990 chr14:35465565 T/C cg16230307 chr14:35515116 FAM177A1 0.85 10.08 0.49 5.15e-21 Psoriasis; CRC cis rs1005277 0.505 rs10827836 chr10:38215441 A/G cg25517755 chr10:38738941 LOC399744 0.46 6.72 0.35 7.91e-11 Extrinsic epigenetic age acceleration; CRC cis rs5753618 0.509 rs5997912 chr22:31593861 A/G cg07713946 chr22:31675144 LIMK2 -0.39 -5.62 -0.3 4e-8 Colorectal cancer; CRC cis rs1003719 0.788 rs2835589 chr21:38463342 A/G cg10648535 chr21:38446584 PIGP;TTC3 0.52 7.36 0.38 1.47e-12 Eye color traits; CRC cis rs4862750 0.957 rs2375916 chr4:187903923 A/G cg24874828 chr4:187887005 NA -0.34 -5.71 -0.3 2.49e-8 Lobe attachment (rater-scored or self-reported); CRC cis rs4481887 1.000 rs4244180 chr1:248471033 A/G cg13385794 chr1:248469461 NA 0.36 6.34 0.33 7.63e-10 Common traits (Other); CRC cis rs798554 0.797 rs798497 chr7:2795957 A/G cg17321639 chr7:2759063 NA -0.51 -7.04 -0.36 1.15e-11 Height; CRC cis rs12908161 1.000 rs11637142 chr15:85295927 A/G cg17507749 chr15:85114479 UBE2QP1 0.61 8.85 0.44 5.43e-17 Schizophrenia; CRC cis rs780096 0.526 rs3845687 chr2:27689899 T/C cg21248554 chr2:27665150 KRTCAP3 -0.32 -7.23 -0.37 3.35e-12 Total body bone mineral density; CRC cis rs8031584 0.578 rs1088473 chr15:31139298 A/G cg08109568 chr15:31115862 NA 0.68 10.6 0.5 8.86e-23 Huntington's disease progression; CRC cis rs2398893 0.960 rs34849895 chr9:96751069 T/C cg14459158 chr9:96720562 NA 0.48 7.65 0.39 2.27e-13 Waist-hip ratio;Waist-to-hip ratio adjusted for body mass index; CRC cis rs1127311 1.000 rs9427094 chr1:154557685 C/T cg17218026 chr1:154582156 ADAR 0.59 9.9 0.48 2.06e-20 C-reactive protein levels or triglyceride levels (pleiotropy); CRC cis rs7618915 0.501 rs3733039 chr3:52719088 C/T cg18099408 chr3:52552593 STAB1 -0.47 -8.01 -0.4 1.99e-14 Bipolar disorder; CRC cis rs12681287 0.547 rs9942793 chr8:87509091 C/T cg27223183 chr8:87520930 FAM82B -0.52 -7.37 -0.38 1.38e-12 Caudate activity during reward; CRC trans rs11098499 0.863 rs10019674 chr4:120443489 C/T cg25214090 chr10:38739885 LOC399744 -0.65 -9.91 -0.48 2e-20 Corneal astigmatism; CRC cis rs2011503 0.943 rs756997 chr19:19467085 G/C cg11584989 chr19:19387371 SF4 -0.53 -6.2 -0.32 1.74e-9 Bipolar disorder; CRC cis rs8177253 0.965 rs1525889 chr3:133490033 A/C cg11941060 chr3:133502564 NA -0.57 -9.78 -0.47 5.3e-20 Iron status biomarkers; CRC cis rs2836974 0.965 rs2836967 chr21:40639102 T/G cg06238570 chr21:40685208 BRWD1 0.79 10.9 0.51 8.19e-24 Cognitive function; CRC cis rs7959452 0.527 rs4761157 chr12:69780907 A/G cg22834771 chr12:69754056 YEATS4 -0.54 -8.1 -0.41 1.07e-14 Blood protein levels; CRC trans rs1005277 0.540 rs1814077 chr10:37992018 G/C cg17830980 chr10:43048298 ZNF37B -0.4 -6.27 -0.33 1.16e-9 Extrinsic epigenetic age acceleration; CRC cis rs798554 0.524 rs2283784 chr7:2855337 T/C cg17321639 chr7:2759063 NA -0.39 -5.85 -0.31 1.17e-8 Height; CRC cis rs1568889 0.838 rs11030265 chr11:28296168 A/T cg06544937 chr11:28130018 METT5D1;KIF18A 0.9 15.18 0.64 8.37e-40 Bipolar disorder; CRC trans rs10504229 1.000 rs17805326 chr8:58169533 A/C cg04077850 chr5:125800366 GRAMD3 0.4 6.66 0.34 1.14e-10 Developmental language disorder (linguistic errors); CRC cis rs2204008 0.905 rs8189449 chr12:38437377 C/A cg13010199 chr12:38710504 ALG10B 0.45 6.02 0.31 4.73e-9 Bladder cancer; CRC cis rs4975616 0.869 rs466502 chr5:1325767 C/T cg06550200 chr5:1325588 CLPTM1L 0.72 11.6 0.54 2.68e-26 Lung cancer; CRC cis rs208520 0.690 rs207094 chr6:66799009 G/A cg07460842 chr6:66804631 NA -1.08 -15.25 -0.64 4.51e-40 Exhaled nitric oxide output; CRC cis rs10256972 0.552 rs6978842 chr7:1204599 A/C cg09177884 chr7:1199841 ZFAND2A -0.55 -8.46 -0.42 8.77e-16 Longevity;Endometriosis; CRC cis rs3087591 0.960 rs10512433 chr17:29600564 T/C cg24425628 chr17:29625626 OMG;NF1 0.85 15.97 0.66 6.51e-43 Hip circumference; CRC cis rs7208859 0.623 rs3752021 chr17:29111043 G/C cg01831904 chr17:28903510 LRRC37B2 -0.63 -6.53 -0.34 2.51e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC trans rs61931739 0.500 rs11053218 chr12:34474792 A/C cg26384229 chr12:38710491 ALG10B -0.64 -8.07 -0.41 1.34e-14 Morning vs. evening chronotype; CRC cis rs10256972 0.552 rs2949195 chr7:1202705 G/A cg27094323 chr7:1216898 NA -0.36 -5.8 -0.3 1.59e-8 Longevity;Endometriosis; CRC cis rs4665809 0.589 rs4665842 chr2:26448954 A/G cg25036284 chr2:26402008 FAM59B -0.61 -7.76 -0.39 1.08e-13 Gut microbiome composition (summer); CRC cis rs2274471 0.645 rs12237834 chr9:5093646 C/T cg03390472 chr9:5043263 JAK2 -0.6 -7.06 -0.36 1.02e-11 Crohn's disease; CRC cis rs4930103 0.935 rs4930110 chr11:2026701 G/C cg23202291 chr11:1979235 NA 0.44 5.96 0.31 6.48e-9 DNA methylation (parent-of-origin);DNA methylation (variation); CRC cis rs875971 0.798 rs57739047 chr7:65972566 A/T cg12463550 chr7:65579703 CRCP 0.49 6.85 0.35 3.67e-11 Aortic root size; CRC trans rs6472235 0.778 rs2357657 chr8:66936490 C/A cg07884673 chr3:53033167 SFMBT1 -0.45 -6.03 -0.32 4.47e-9 Myopia (pathological);Plateletcrit; CRC cis rs1799949 1.000 rs8176296 chr17:41203591 T/C cg25072359 chr17:41440525 NA 0.45 6.82 0.35 4.26e-11 Menopause (age at onset); CRC trans rs7267979 0.966 rs6050532 chr20:25308793 A/T cg17903999 chr18:56338584 MALT1 0.42 6.93 0.36 2.23e-11 Liver enzyme levels (alkaline phosphatase); CRC cis rs896854 0.738 rs2515226 chr8:95965743 G/A cg16049864 chr8:95962084 TP53INP1 0.57 8.9 0.44 3.96e-17 Type 2 diabetes; CRC cis rs4731207 0.623 rs34865746 chr7:124639919 T/A cg23710748 chr7:124431027 NA -0.42 -6.69 -0.35 9.45e-11 Cutaneous malignant melanoma; CRC cis rs2404602 0.716 rs17364076 chr15:76760891 C/T cg00316803 chr15:76480434 C15orf27 -0.35 -5.79 -0.3 1.63e-8 Blood metabolite levels; CRC cis rs13202913 0.518 rs13205543 chr6:151813779 C/T cg10883421 chr6:151773342 RMND1;C6orf211 0.63 6.89 0.36 2.8e-11 Epstein-Barr virus copy number in lymphoblastoid cell lines; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg16221875 chr6:21588597 NA 0.46 6.62 0.34 1.45e-10 Response to antipsychotic treatment; CRC cis rs35740288 0.571 rs11629608 chr15:86330124 C/G cg20737812 chr15:86336631 KLHL25 -0.44 -6.99 -0.36 1.52e-11 Eosinophil percentage of white cells;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes; CRC trans rs6550704 0.687 rs9865314 chr3:22634337 A/G cg08167214 chr16:81040017 CENPN;C16orf61 -0.42 -6.07 -0.32 3.58e-9 Daytime sleep phenotypes; CRC cis rs2836974 0.568 rs11910906 chr21:40685662 T/C cg17971929 chr21:40555470 PSMG1 -0.67 -9.72 -0.47 8.55e-20 Cognitive function; CRC cis rs13256369 1.000 rs873063 chr8:8572447 A/G cg17143192 chr8:8559678 CLDN23 0.46 5.92 0.31 8.3e-9 Obesity-related traits; CRC cis rs9322193 0.923 rs12176034 chr6:150121693 C/T cg05861140 chr6:150128134 PCMT1 -0.38 -5.8 -0.3 1.57e-8 Lung cancer; CRC cis rs12760731 0.582 rs6676116 chr1:178566778 G/A cg00404053 chr1:178313656 RASAL2 0.66 7.38 0.38 1.29e-12 Obesity-related traits; CRC cis rs634534 0.622 rs552130 chr11:65732800 T/C cg26695010 chr11:65641043 EFEMP2 -0.39 -6.11 -0.32 2.8e-9 Sum eosinophil basophil counts;Eosinophil counts; CRC cis rs7659604 0.582 rs3217780 chr4:122737278 T/C cg06713675 chr4:122721982 EXOSC9 -0.51 -8.33 -0.42 2.25e-15 Type 2 diabetes; CRC cis rs908922 0.676 rs7529441 chr1:152531629 A/G cg23254163 chr1:152506842 NA -0.48 -9.71 -0.47 9.2e-20 Hair morphology; CRC cis rs10847980 0.590 rs1979236 chr12:123325993 G/A cg25930673 chr12:123319894 HIP1R 0.69 5.85 0.31 1.17e-8 Adiponectin levels; CRC trans rs12599106 0.709 rs1501462 chr16:34964515 A/T cg21548813 chr6:291882 DUSP22 -0.67 -9.74 -0.47 7.34e-20 Menopause (age at onset); CRC cis rs9322193 0.923 rs12211511 chr6:150066342 G/C cg05861140 chr6:150128134 PCMT1 -0.42 -6.95 -0.36 1.91e-11 Lung cancer; CRC cis rs17023223 0.537 rs10923759 chr1:119692194 A/G cg05756136 chr1:119680316 WARS2 0.52 7.14 0.37 6.01e-12 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for BMI in active individuals; CRC cis rs4919087 1.000 rs4919087 chr10:99072507 C/T cg25902810 chr10:99078978 FRAT1 -0.38 -5.89 -0.31 9.77e-9 Monocyte count; CRC cis rs4805272 0.539 rs1075733 chr19:29324460 C/T cg12756686 chr19:29218302 NA 0.44 5.97 0.31 6.17e-9 Plasma omega-3 polyunsaturated fatty acid levels (docosahexaenoic acid); CRC cis rs4803468 1.000 rs284650 chr19:41927129 A/G cg09537434 chr19:41945824 ATP5SL -0.97 -18.39 -0.71 1.96e-52 Height; CRC trans rs66887589 0.775 rs6843229 chr4:120424087 T/C cg25214090 chr10:38739885 LOC399744 0.4 6.12 0.32 2.73e-9 Diastolic blood pressure; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg03278989 chr19:54693461 MBOAT7;TSEN34 0.41 6.38 0.33 5.91e-10 Liver disease severity in Alagille syndrome; CRC cis rs7208859 0.673 rs8077116 chr17:29140162 A/G cg13385521 chr17:29058706 SUZ12P 0.74 8.44 0.42 9.97e-16 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs875971 1.000 rs3735148 chr7:65971009 T/G cg12463550 chr7:65579703 CRCP 0.47 6.79 0.35 5.17e-11 Aortic root size; CRC cis rs6502050 0.799 rs7502533 chr17:80109778 A/G cg25804541 chr17:80189381 SLC16A3 -0.31 -5.97 -0.31 6.08e-9 Life satisfaction; CRC cis rs270601 0.739 rs1979981 chr5:131601720 G/A cg12564285 chr5:131593104 PDLIM4 0.54 10.42 0.5 3.71e-22 Acylcarnitine levels; CRC cis rs72781680 0.898 rs2879640 chr2:24043573 T/C cg08917208 chr2:24149416 ATAD2B 0.9 9.13 0.45 6.96e-18 Lymphocyte counts; CRC cis rs2549003 1.000 rs7701588 chr5:131819970 T/C cg02551604 chr5:131831745 NA -0.54 -8.34 -0.42 2e-15 Asthma (sex interaction); CRC trans rs7647973 0.626 rs4855846 chr3:49683526 G/A cg21659725 chr3:3221576 CRBN -0.67 -7.34 -0.38 1.72e-12 Menarche (age at onset); CRC trans rs7553035 1.000 rs7542785 chr1:211691580 A/T cg04286297 chr15:83655119 FAM103A1 -0.67 -6.02 -0.31 4.66e-9 Retinopathy in non-diabetics; CRC cis rs7618915 0.570 rs11130312 chr3:52675055 A/C cg07507251 chr3:52567010 NT5DC2 0.42 6.04 0.32 4.11e-9 Bipolar disorder; CRC cis rs739401 1.000 rs739401 chr11:3036324 C/T cg08508325 chr11:3079039 CARS 0.39 7.04 0.36 1.13e-11 Longevity; CRC cis rs6500395 1.000 rs1004909 chr16:48725580 C/G cg04672837 chr16:48644449 N4BP1 -0.44 -6.48 -0.34 3.28e-10 Response to tocilizumab in rheumatoid arthritis; CRC cis rs970548 0.954 rs10900221 chr10:45988597 G/A cg15590007 chr10:45870220 ALOX5 0.48 6.03 0.32 4.49e-9 Total cholesterol levels;Cholesterol, total;HDL cholesterol;HDL cholesterol levels; CRC cis rs7726839 0.540 rs3792720 chr5:643028 T/G cg09021430 chr5:549028 NA -0.73 -8.31 -0.42 2.6e-15 Obesity-related traits; CRC cis rs55823223 0.618 rs11867339 chr17:73862093 A/G cg14829360 chr17:73884958 NA -0.44 -6.34 -0.33 7.57e-10 Psoriasis; CRC cis rs9303401 0.659 rs17822908 chr17:56801778 T/C cg02118635 chr17:56770003 RAD51C;TEX14 0.79 10.13 0.49 3.5e-21 Cognitive test performance; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg18834200 chr2:172017416 TLK1 0.5 7.37 0.38 1.4e-12 Intelligence (multi-trait analysis); CRC cis rs2290405 0.527 rs4690329 chr4:931385 T/A cg09237302 chr4:906077 GAK -0.43 -7.28 -0.37 2.41e-12 Systemic sclerosis; CRC cis rs2806561 0.765 rs1612905 chr1:23510023 G/T cg12483005 chr1:23474871 LUZP1 0.49 7.09 0.36 8.17e-12 Height; CRC cis rs8180040 0.800 rs7632501 chr3:47268306 T/C cg10298567 chr3:47292165 KIF9 0.41 6.38 0.33 5.89e-10 Colorectal cancer; CRC cis rs13118159 0.714 rs6843025 chr4:1334418 C/G cg21620606 chr4:1342894 KIAA1530 0.52 9.57 0.47 2.74e-19 Longevity; CRC cis rs1552244 1.000 rs61052895 chr3:10147516 G/A cg02579736 chr3:10068473 FANCD2;CIDECP 1.03 13.67 0.6 5.57e-34 Alzheimer's disease; CRC trans rs2243480 0.901 rs73142137 chr7:65343442 A/T cg10756647 chr7:56101905 PSPH 0.69 7.1 0.36 7.8e-12 Diabetic kidney disease; CRC trans rs7615952 0.512 rs2979334 chr3:125358824 G/A cg02560186 chr11:3602584 NA -0.63 -9.54 -0.47 3.23e-19 Blood pressure (smoking interaction); CRC cis rs2303745 0.589 rs11086065 chr19:17395003 A/G cg04248312 chr19:17393744 ANKLE1 -0.93 -14.45 -0.62 5.58e-37 Systemic lupus erythematosus; CRC cis rs13161895 0.877 rs75654641 chr5:179486021 C/T cg02702477 chr5:179499311 RNF130 0.7 7.39 0.38 1.19e-12 LDL cholesterol; CRC cis rs10911363 0.592 rs2702182 chr1:183516440 C/T cg09173681 chr1:183549694 NCF2 0.73 10.31 0.49 8.54e-22 Systemic lupus erythematosus; CRC cis rs17270561 0.609 rs1165208 chr6:25803904 G/A cg17691542 chr6:26056736 HIST1H1C 0.52 7.19 0.37 4.47e-12 Iron status biomarkers; CRC trans rs12699921 0.632 rs2723501 chr7:17854532 A/C cg15753394 chr6:17282781 RBM24 0.37 6.33 0.33 7.84e-10 Fibrinogen levels; CRC cis rs6754459 0.502 rs34759180 chr2:3707394 C/T cg25251562 chr2:3704773 ALLC -0.96 -11.53 -0.54 4.55e-26 Response to inhaled corticosteroid treatment in asthma (change in FEV1); CRC cis rs9992667 0.955 rs28491682 chr4:38640889 T/C cg19726192 chr4:38663646 FLJ13197 -0.67 -8.6 -0.43 3.31e-16 Eosinophil percentage of granulocytes; CRC cis rs8081692 1 rs8081692 chr17:38154595 A/G cg17467752 chr17:38218738 THRA 0.74 11.83 0.55 3.96e-27 Neutrophil count; CRC cis rs10256972 0.706 rs4285396 chr7:1123738 A/G cg18402987 chr7:1209562 NA 0.45 6.45 0.34 3.98e-10 Longevity;Endometriosis; CRC cis rs7953508 0.636 rs10859535 chr12:93979892 A/G cg18151635 chr12:93972918 NA -0.74 -9.95 -0.48 1.47e-20 Pubertal anthropometrics; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg23163999 chr3:125803012 SLC41A3 0.37 5.97 0.31 6.26e-9 Liver disease severity in Alagille syndrome; CRC cis rs10992471 0.528 rs1924243 chr9:95224847 C/T cg14631576 chr9:95140430 CENPP -0.31 -5.63 -0.3 3.86e-8 Visceral adipose tissue/subcutaneous adipose tissue ratio; CRC cis rs45509595 0.822 rs200484 chr6:27775674 A/G cg26587870 chr6:27730563 NA -0.6 -6.0 -0.31 5.32e-9 Breast cancer; CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg16104446 chr8:48873951 MCM4;PRKDC -0.55 -6.72 -0.35 7.85e-11 Diisocyanate-induced asthma; CRC cis rs7726839 0.561 rs72703058 chr5:584519 G/A cg16447950 chr5:562315 NA -0.85 -12.53 -0.57 1.01e-29 Obesity-related traits; CRC trans rs2243480 1.000 rs6460260 chr7:65215455 T/C cg10756647 chr7:56101905 PSPH -0.73 -7.62 -0.39 2.71e-13 Diabetic kidney disease; CRC cis rs7731657 0.510 rs986496 chr5:130282172 C/T cg08523029 chr5:130500466 HINT1 0.49 6.19 0.32 1.83e-9 Fasting plasma glucose; CRC cis rs6831352 0.918 rs29001201 chr4:100053861 T/C cg12011299 chr4:100065546 ADH4 -0.49 -9.17 -0.45 5.32e-18 Alcohol dependence; CRC cis rs2180341 0.814 rs7768435 chr6:127737038 A/C cg24812749 chr6:127587940 RNF146 0.67 9.02 0.45 1.59e-17 Breast cancer; CRC cis rs6060717 0.610 rs6060755 chr20:34606915 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.44 -6.34 -0.33 7.44e-10 Hip circumference adjusted for BMI; CRC cis rs1008375 0.898 rs4698620 chr4:17587361 C/T cg16339924 chr4:17578868 LAP3 0.6 7.89 0.4 4.4e-14 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs7552404 0.727 rs5745427 chr1:76332637 C/A cg22875332 chr1:76189707 ACADM -0.52 -6.9 -0.36 2.75e-11 Blood metabolite levels;Acylcarnitine levels; CRC cis rs853679 0.517 rs4713146 chr6:28111536 A/T cg02683197 chr6:28174875 NA 0.87 10.73 0.51 3.25e-23 Depression; CRC cis rs7980687 0.638 rs7299943 chr12:123593485 A/T cg00376283 chr12:123451042 ABCB9 0.54 6.98 0.36 1.62e-11 Height;Educational attainment;Head circumference (infant); CRC cis rs7172809 0.643 rs61097729 chr15:77834358 C/G cg10437265 chr15:77819839 NA -0.37 -5.97 -0.31 6.13e-9 Glucose homeostasis traits; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg15450734 chr14:103541957 NA 0.48 6.25 0.33 1.27e-9 Thyroid stimulating hormone; CRC cis rs4713118 0.869 rs6914924 chr6:27711530 C/T cg12273811 chr6:28175739 NA 0.53 7.64 0.39 2.4e-13 Parkinson's disease; CRC cis rs10876993 0.928 rs1689595 chr12:58056763 C/T cg15848620 chr12:58087721 OS9 -0.64 -9.04 -0.45 1.35e-17 Celiac disease or Rheumatoid arthritis; CRC cis rs6424115 0.830 rs2502993 chr1:24201262 A/G cg10978503 chr1:24200527 CNR2 0.61 11.06 0.52 2.22e-24 Immature fraction of reticulocytes; CRC cis rs4862750 0.872 rs11947595 chr4:187899827 C/T cg27532560 chr4:187881888 NA -0.57 -10.58 -0.5 1.04e-22 Lobe attachment (rater-scored or self-reported); CRC cis rs9818758 0.505 rs11716159 chr3:49631585 G/A cg00383909 chr3:49044727 WDR6 1.38 12.03 0.55 6.85e-28 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; CRC cis rs3087591 0.708 rs7502834 chr17:29689430 G/A cg24425628 chr17:29625626 OMG;NF1 0.73 13.12 0.59 6.19e-32 Hip circumference; CRC cis rs9287719 0.967 rs4555318 chr2:10744295 C/G cg00105475 chr2:10696890 NA 0.45 7.3 0.37 2.2e-12 Prostate cancer; CRC cis rs13191362 0.935 rs13193473 chr6:162966852 C/A cg06582575 chr6:163149167 PACRG;PARK2 0.81 10.1 0.49 4.39e-21 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs10504229 0.728 rs55812114 chr8:58157453 C/T cg02290350 chr8:58132656 NA -0.51 -6.39 -0.33 5.68e-10 Developmental language disorder (linguistic errors); CRC cis rs9733 0.569 rs11588404 chr1:150688529 C/A cg15448220 chr1:150897856 SETDB1 0.45 6.41 0.33 5.09e-10 Tonsillectomy; CRC cis rs9894429 0.646 rs6565609 chr17:79592267 G/A cg18240062 chr17:79603768 NPLOC4 0.48 7.59 0.39 3.36e-13 Eye color traits; CRC cis rs7829975 0.711 rs4841051 chr8:8685646 C/T cg08975724 chr8:8085496 FLJ10661 -0.4 -6.44 -0.33 4.26e-10 Mood instability; CRC cis rs1005277 0.557 rs1854563 chr10:38434961 G/A cg00409905 chr10:38381863 ZNF37A -0.67 -11.16 -0.52 9.81e-25 Extrinsic epigenetic age acceleration; CRC cis rs1215050 0.791 rs155019 chr4:98759126 G/A cg05340658 chr4:99064831 C4orf37 0.47 6.88 0.35 3.09e-11 Waist-to-hip ratio adjusted for body mass index; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg02139671 chr12:123237174 DENR 0.44 6.08 0.32 3.29e-9 Response to antipsychotic treatment; CRC cis rs7824557 0.564 rs12550129 chr8:11233917 C/T cg20542592 chr8:11973495 FAM66D 0.34 5.9 0.31 8.92e-9 Retinal vascular caliber; CRC cis rs858239 0.863 rs274058 chr7:23391509 C/G cg00469287 chr7:23338798 C7orf30 0.47 6.32 0.33 8.33e-10 Cerebrospinal fluid biomarker levels; CRC cis rs1005277 0.579 rs2472173 chr10:38374638 G/A cg25517755 chr10:38738941 LOC399744 -0.44 -6.43 -0.33 4.54e-10 Extrinsic epigenetic age acceleration; CRC cis rs13108904 0.870 rs4974541 chr4:1244037 A/G cg00684032 chr4:1343700 KIAA1530 0.41 6.39 0.33 5.56e-10 Obesity-related traits; CRC cis rs8078723 1.000 rs59925331 chr17:38169273 C/G cg17467752 chr17:38218738 THRA 0.73 12.02 0.55 8e-28 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); CRC cis rs2046867 0.862 rs7648954 chr3:72838756 C/A cg25664220 chr3:72788482 NA -0.38 -5.79 -0.3 1.63e-8 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; CRC cis rs6681460 0.932 rs603750 chr1:67177488 A/G cg02459107 chr1:67143332 SGIP1 0.38 6.6 0.34 1.69e-10 Presence of antiphospholipid antibodies; CRC cis rs769267 0.895 rs1000237 chr19:19518316 T/A cg03709012 chr19:19516395 GATAD2A 0.72 11.45 0.53 8.76e-26 Tonsillectomy; CRC cis rs4665809 0.627 rs13032756 chr2:26489730 A/T cg27170947 chr2:26402098 FAM59B 0.62 8.22 0.41 4.87e-15 Gut microbiome composition (summer); CRC trans rs459571 0.839 rs10993895 chr9:136887726 C/T cg09836344 chr4:1243392 C4orf42;CTBP1 0.82 11.84 0.55 3.62e-27 Platelet distribution width; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg25026715 chr17:26989248 SUPT6H;SDF2 0.39 6.91 0.36 2.56e-11 Liver disease severity in Alagille syndrome; CRC cis rs7208859 0.673 rs9899525 chr17:29120296 T/A cg01831904 chr17:28903510 LRRC37B2 -0.62 -6.41 -0.33 5.13e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs7923609 0.967 rs7896783 chr10:65162153 G/A cg08743896 chr10:65200160 JMJD1C -0.43 -6.2 -0.32 1.7e-9 Educational attainment;Liver enzyme levels (alkaline phosphatase); CRC cis rs7103648 0.695 rs12223593 chr11:47789082 T/G cg20307385 chr11:47447363 PSMC3 0.75 10.26 0.49 1.33e-21 Diastolic blood pressure;Systolic blood pressure; CRC cis rs3733585 0.648 rs35954357 chr4:9978758 G/C cg11266682 chr4:10021025 SLC2A9 0.46 9.25 0.45 2.98e-18 Cleft plate (environmental tobacco smoke interaction); CRC cis rs7264396 1.000 rs224435 chr20:34154087 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.44 -7.15 -0.37 5.83e-12 Total cholesterol levels; CRC trans rs1814175 0.615 rs12417290 chr11:49876951 G/A cg03929089 chr4:120376271 NA -0.91 -15.93 -0.66 9.48e-43 Height; CRC trans rs2727020 0.638 rs1164668 chr11:49330627 A/C cg03929089 chr4:120376271 NA 0.82 14.15 0.62 8.01e-36 Coronary artery disease; CRC cis rs644799 0.965 rs573758 chr11:95539591 G/T cg25622487 chr11:95524042 FAM76B;CEP57 0.76 11.87 0.55 2.62e-27 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs7725052 0.609 rs6874477 chr5:40457892 C/T cg09067459 chr5:40385259 NA -0.4 -6.68 -0.35 9.91e-11 Pediatric autoimmune diseases; CRC cis rs6938 0.597 rs11856413 chr15:75199892 A/G cg09165964 chr15:75287851 SCAMP5 0.56 8.68 0.43 1.82e-16 Breast cancer; CRC cis rs2730260 0.537 rs73169248 chr7:158891742 T/G cg02254261 chr7:158964346 NA -0.54 -6.19 -0.32 1.8e-9 Myopia (pathological); CRC cis rs9457247 1.000 rs422780 chr6:167406209 A/G cg23791538 chr6:167370224 RNASET2 -0.38 -5.94 -0.31 7.32e-9 Crohn's disease; CRC cis rs1023500 0.573 rs133380 chr22:42468910 C/T cg04733989 chr22:42467013 NAGA 0.56 8.48 0.42 7.99e-16 Schizophrenia; CRC cis rs2976388 0.609 rs1469811 chr8:143787999 C/T cg05569086 chr8:143859399 LYNX1 0.4 6.88 0.35 3.01e-11 Urinary tract infection frequency; CRC cis rs2404602 0.716 rs1946650 chr15:76848463 T/C cg23625390 chr15:77176239 SCAPER 0.5 7.45 0.38 8.38e-13 Blood metabolite levels; CRC cis rs4604732 0.536 rs12049066 chr1:247642655 C/T cg02104434 chr1:247694406 LOC148824;OR2C3 0.55 8.37 0.42 1.62e-15 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CRC cis rs1005277 0.540 rs289638 chr10:37923731 G/A cg00409905 chr10:38381863 ZNF37A -0.62 -9.97 -0.48 1.23e-20 Extrinsic epigenetic age acceleration; CRC cis rs3087591 1.000 rs2952989 chr17:29516113 G/A cg24425628 chr17:29625626 OMG;NF1 0.85 16.13 0.66 1.55e-43 Hip circumference; CRC cis rs11155671 0.530 rs2342770 chr6:150216685 C/T cg07701084 chr6:150067640 NUP43 0.53 7.47 0.38 7.29e-13 Testicular germ cell tumor; CRC cis rs4563143 0.675 rs55884228 chr19:29243897 G/T cg03161606 chr19:29218774 NA 0.52 6.52 0.34 2.68e-10 Methadone dose in opioid dependence; CRC cis rs10751667 0.666 rs7124480 chr11:971601 G/A cg23136738 chr11:925521 AP2A2 -0.41 -6.86 -0.35 3.48e-11 Alzheimer's disease (late onset); CRC cis rs9399137 0.507 rs4520025 chr6:135278619 G/T cg24558204 chr6:135376177 HBS1L 0.6 8.73 0.43 1.26e-16 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; CRC trans rs1005277 0.579 rs2505248 chr10:38459097 A/G cg17830980 chr10:43048298 ZNF37B -0.6 -10.0 -0.48 9.53e-21 Extrinsic epigenetic age acceleration; CRC cis rs9322193 0.923 rs9322207 chr6:149978321 G/A cg05861140 chr6:150128134 PCMT1 -0.36 -5.83 -0.31 1.36e-8 Lung cancer; CRC cis rs1045714 0.895 rs4721866 chr7:2643341 G/A cg24848437 chr7:2645542 IQCE 0.56 5.98 0.31 5.87e-9 Urate levels in lean individuals; CRC cis rs7666738 1.000 rs880473 chr4:98922596 C/T cg05340658 chr4:99064831 C4orf37 0.5 7.01 0.36 1.37e-11 Colonoscopy-negative controls vs population controls; CRC cis rs3126085 0.935 rs7537637 chr1:152223335 T/A cg09127314 chr1:152161683 NA 0.46 5.93 0.31 7.69e-9 Atopic dermatitis; CRC cis rs9549260 0.755 rs2701869 chr13:41157372 G/A cg21288729 chr13:41239152 FOXO1 0.38 5.84 0.31 1.25e-8 Red blood cell count; CRC cis rs2239547 0.603 rs6805298 chr3:53096552 A/G cg15147215 chr3:52552868 STAB1 0.4 5.66 0.3 3.31e-8 Schizophrenia; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg19951424 chr15:89182208 ISG20 0.4 5.99 0.31 5.42e-9 Response to antipsychotic treatment; CRC cis rs6662572 0.901 rs58692133 chr1:46067269 G/A cg08644498 chr1:46502608 NA 0.46 6.6 0.34 1.67e-10 Blood protein levels; CRC cis rs10504229 0.683 rs6999131 chr8:58127052 C/A cg02725872 chr8:58115012 NA -0.57 -8.24 -0.41 4.03e-15 Developmental language disorder (linguistic errors); CRC cis rs6502050 0.769 rs9916231 chr17:80119645 A/G cg02741985 chr17:80059408 CCDC57 0.4 6.59 0.34 1.74e-10 Life satisfaction; CRC trans rs1814175 0.817 rs7946556 chr11:49944874 G/A cg21153622 chr11:89784906 NA -0.38 -6.05 -0.32 3.99e-9 Height; CRC cis rs6951245 1.000 rs74887741 chr7:1110658 G/T cg03188948 chr7:1209495 NA 0.67 6.96 0.36 1.83e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs72945132 0.660 rs12292191 chr11:70122426 T/C cg00319359 chr11:70116639 PPFIA1 0.62 6.88 0.35 3.02e-11 Coronary artery disease; CRC cis rs9322193 0.923 rs9689716 chr6:149976798 G/A cg00933542 chr6:150070202 PCMT1 0.31 6.32 0.33 8.47e-10 Lung cancer; CRC cis rs6662572 0.737 rs6429590 chr1:46457250 T/C cg08644498 chr1:46502608 NA 0.46 7.18 0.37 4.79e-12 Blood protein levels; CRC cis rs7215564 0.908 rs8074870 chr17:78684132 T/C cg09596252 chr17:78655493 RPTOR 0.58 6.24 0.33 1.36e-9 Myopia (pathological); CRC cis rs2342371 0.756 rs3973 chr3:196124278 A/G cg15048948 chr3:196158458 UBXN7 -0.49 -6.05 -0.32 3.89e-9 Fat distribution (HIV); CRC cis rs10504229 0.683 rs7822631 chr8:58130916 C/G cg21724239 chr8:58056113 NA 0.49 6.81 0.35 4.75e-11 Developmental language disorder (linguistic errors); CRC cis rs57221529 0.766 rs12521988 chr5:556421 C/T cg16447950 chr5:562315 NA -0.84 -11.5 -0.54 6.14e-26 Lung disease severity in cystic fibrosis; CRC cis rs11809207 0.574 rs2783631 chr1:26504756 C/T cg24519413 chr1:26490540 NA 0.37 6.29 0.33 1.01e-9 Height; CRC cis rs769267 0.931 rs2965197 chr19:19470910 C/T cg03709012 chr19:19516395 GATAD2A -0.7 -10.61 -0.5 8.03e-23 Tonsillectomy; CRC cis rs11098499 0.575 rs907204 chr4:120238654 G/A cg24375607 chr4:120327624 NA 0.48 7.64 0.39 2.32e-13 Corneal astigmatism; CRC cis rs73206853 0.841 rs73206854 chr12:110731375 C/T cg12870014 chr12:110450643 ANKRD13A 0.85 10.3 0.49 9.44e-22 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC cis rs2718058 0.601 rs2709104 chr7:37762810 A/G cg24998770 chr7:37888106 TXNDC3 -0.36 -5.9 -0.31 8.94e-9 Alzheimer's disease (late onset); CRC cis rs1475911 0.656 rs9980065 chr21:43528072 G/A cg14562523 chr21:43528734 C21orf128;UMODL1 -0.65 -8.71 -0.43 1.51e-16 IgG glycosylation; CRC cis rs2651899 0.902 rs2742673 chr1:3080019 A/C cg22674798 chr1:3096360 PRDM16 -0.37 -7.78 -0.39 9.29e-14 Migraine; CRC trans rs1455244 0.700 rs7229302 chr18:11508904 G/T cg17749468 chr2:202316740 STRADB;TRAK2 0.4 6.1 0.32 3.02e-9 Schizophrenia; CRC cis rs12188164 1.000 rs34847072 chr5:437862 G/C cg26850624 chr5:429559 AHRR -0.81 -13.83 -0.61 1.3e-34 Cystic fibrosis severity; CRC cis rs1862618 0.853 rs860580 chr5:56149429 G/T cg03609598 chr5:56110824 MAP3K1 0.81 10.08 0.49 5.5e-21 Initial pursuit acceleration; CRC cis rs7618915 0.571 rs11130307 chr3:52607682 G/A cg07507251 chr3:52567010 NT5DC2 0.46 6.72 0.35 8.08e-11 Bipolar disorder; CRC cis rs2075371 0.863 rs1646635 chr7:134006728 T/C cg11752832 chr7:134001865 SLC35B4 0.49 7.73 0.39 1.35e-13 Mean platelet volume; CRC cis rs889312 0.500 rs702691 chr5:56114526 T/G cg03609598 chr5:56110824 MAP3K1 -0.43 -6.07 -0.32 3.55e-9 Breast cancer;Breast cancer (early onset); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg04896168 chr1:86968543 NA 0.42 7.55 0.38 4.4e-13 Liver disease severity in Alagille syndrome; CRC trans rs17041 0.783 rs7760776 chr6:108794758 T/A cg06439005 chr5:172754848 STC2 -0.37 -5.99 -0.31 5.46e-9 Obesity-related traits; CRC cis rs9322193 0.886 rs10872652 chr6:150096439 C/T cg07701084 chr6:150067640 NUP43 0.47 6.61 0.34 1.51e-10 Lung cancer; CRC cis rs7772486 0.754 rs857881 chr6:145970793 C/A cg23711669 chr6:146136114 FBXO30 -0.75 -12.49 -0.57 1.45e-29 Lobe attachment (rater-scored or self-reported); CRC cis rs12900413 0.687 rs12908489 chr15:90304269 A/G cg24249390 chr15:90295951 MESP1 -0.57 -8.72 -0.43 1.39e-16 Coronary artery aneurysm in Kawasaki disease; CRC cis rs7572644 0.640 rs11901133 chr2:28069713 T/G cg27432699 chr2:27873401 GPN1 0.45 6.1 0.32 3.03e-9 Response to carboplatin and paclitaxel in ovarian cancer (Caspase 3/7 EC50); CRC cis rs6594713 0.643 rs10077431 chr5:112927686 A/C cg12552261 chr5:112820674 MCC -0.46 -6.09 -0.32 3.2e-9 Brain cytoarchitecture; CRC cis rs2882667 0.898 rs6882330 chr5:138382182 A/G cg04439458 chr5:138467593 SIL1 -0.33 -5.99 -0.31 5.53e-9 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs763121 0.853 rs3788545 chr22:39065172 A/G cg06022373 chr22:39101656 GTPBP1 0.78 12.3 0.56 7.14e-29 Menopause (age at onset); CRC cis rs12048904 0.647 rs7528268 chr1:101329295 A/G cg16556008 chr1:101360663 SLC30A7;EXTL2 0.92 15.05 0.64 2.61e-39 Multiple sclerosis; CRC cis rs8031584 0.723 rs711224 chr15:31127921 G/C cg14829155 chr15:31115871 NA 0.63 10.16 0.49 2.94e-21 Huntington's disease progression; CRC cis rs2495707 0.624 rs2489006 chr10:102419893 G/A cg17156803 chr10:102416598 NA -0.33 -5.64 -0.3 3.72e-8 Body mass index; CRC cis rs1348850 0.574 rs10195917 chr2:178443121 C/T cg27490568 chr2:178487706 NA 0.46 6.47 0.34 3.65e-10 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs3820068 0.581 rs58425551 chr1:15922518 A/G cg27534772 chr1:16042836 PLEKHM2 0.54 10.43 0.5 3.54e-22 Systolic blood pressure; CRC cis rs4665809 0.590 rs4665313 chr2:26415897 A/G cg27170947 chr2:26402098 FAM59B -0.61 -7.87 -0.4 5.02e-14 Gut microbiome composition (summer); CRC trans rs7267979 1.000 rs2259837 chr20:25280205 T/C cg17903999 chr18:56338584 MALT1 -0.42 -6.99 -0.36 1.52e-11 Liver enzyme levels (alkaline phosphatase); CRC cis rs2066819 0.892 rs112931321 chr12:56667894 C/T cg26714650 chr12:56694279 CS -1.41 -11.64 -0.54 1.88e-26 Psoriasis vulgaris; CRC trans rs116095464 0.558 rs6881920 chr5:222411 T/C cg00938859 chr5:1591904 SDHAP3 0.68 7.39 0.38 1.24e-12 Breast cancer; CRC cis rs55702914 0.809 rs6738721 chr2:198182334 A/G cg10820045 chr2:198174542 NA -0.49 -9.15 -0.45 6.19e-18 Major depression and alcohol dependence; CRC cis rs7777754 0.512 rs4470989 chr7:50562698 T/A cg14593290 chr7:50529359 DDC -0.51 -7.59 -0.39 3.32e-13 Response to zileuton treatment in asthma (FEV1 change interaction); CRC cis rs7223966 1.000 rs73337598 chr17:61732576 T/C cg23903597 chr17:61704154 MAP3K3 -0.42 -5.74 -0.3 2.21e-8 Hip circumference adjusted for BMI;Body mass index; CRC cis rs6502050 0.835 rs4459614 chr17:80086597 C/T cg02741985 chr17:80059408 CCDC57 -0.41 -6.7 -0.35 9.13e-11 Life satisfaction; CRC cis rs1348850 0.668 rs6734426 chr2:178493770 C/T cg22681709 chr2:178499509 PDE11A -0.4 -6.67 -0.35 1.1e-10 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC trans rs8002861 0.935 rs9533678 chr13:44463409 C/T cg17145862 chr1:211918768 LPGAT1 0.77 15.65 0.65 1.16e-41 Leprosy; CRC cis rs9287719 0.600 rs10197187 chr2:10726639 A/T cg00105475 chr2:10696890 NA 0.44 7.0 0.36 1.43e-11 Prostate cancer; CRC cis rs7264396 0.563 rs2425119 chr20:34324216 C/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.49 -6.55 -0.34 2.15e-10 Total cholesterol levels; CRC cis rs989128 0.642 rs8076628 chr17:48626626 G/A cg24438145 chr17:48624694 SPATA20 0.52 7.41 0.38 1.04e-12 Type 2 diabetes; CRC cis rs4073416 0.542 rs9323460 chr14:65933199 T/G cg03016385 chr14:66212404 NA -0.41 -5.65 -0.3 3.45e-8 N-glycan levels; CRC cis rs6952808 0.723 rs1107592 chr7:2041432 C/T cg18279126 chr7:2041391 MAD1L1 -0.46 -7.24 -0.37 3.12e-12 Bipolar disorder and schizophrenia; CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg06385324 chr16:2014621 SNHG9;SNORA78;RPS2 -0.47 -5.96 -0.31 6.45e-9 Diisocyanate-induced asthma; CRC cis rs6500602 0.682 rs3761679 chr16:4457907 C/G cg08645402 chr16:4508243 NA 0.54 7.43 0.38 9.53e-13 Schizophrenia; CRC cis rs9325144 0.671 rs35817541 chr12:38975001 T/C cg13010199 chr12:38710504 ALG10B -0.4 -5.6 -0.3 4.5e-8 Morning vs. evening chronotype; CRC cis rs1153858 1.000 rs16942568 chr15:45677390 T/C cg14582100 chr15:45693742 SPATA5L1 0.28 5.77 0.3 1.88e-8 Homoarginine levels; CRC cis rs172166 0.694 rs1770131 chr6:28086413 C/T cg12273811 chr6:28175739 NA 0.61 8.84 0.44 5.98e-17 Cardiac Troponin-T levels; CRC cis rs155076 1.000 rs155076 chr13:21870114 A/G cg25811766 chr13:21894605 NA -0.57 -6.26 -0.33 1.18e-9 White matter hyperintensity burden; CRC cis rs7208859 0.623 rs8068645 chr17:29104342 T/A cg01831904 chr17:28903510 LRRC37B2 -0.63 -6.43 -0.33 4.56e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs11864453 0.611 rs1050361 chr16:72130203 C/G cg23815491 chr16:72088622 HP 0.52 7.96 0.4 2.74e-14 Fibrinogen levels; CRC cis rs9381040 0.610 rs9394758 chr6:41017821 C/T cg25110423 chr6:41068646 NFYA;LOC221442 -0.37 -5.75 -0.3 2.08e-8 Alzheimer's disease (late onset); CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg04408225 chr14:95623684 DICER1;FLJ45244 -0.41 -6.01 -0.31 4.98e-9 Myopia (pathological); CRC cis rs208520 0.955 rs12204033 chr6:67001525 T/C cg07460842 chr6:66804631 NA 0.84 10.26 0.49 1.32e-21 Exhaled nitric oxide output; CRC cis rs853679 0.517 rs9368552 chr6:28068426 A/G cg25164649 chr6:28176230 NA 0.75 9.32 0.46 1.72e-18 Depression; CRC cis rs910187 0.678 rs1046659 chr20:45817068 G/A cg27589058 chr20:45804311 EYA2 -0.43 -8.27 -0.41 3.44e-15 Migraine; CRC cis rs4862750 0.872 rs11947595 chr4:187899827 C/T cg03647317 chr4:187891568 NA -0.54 -10.28 -0.49 1.09e-21 Lobe attachment (rater-scored or self-reported); CRC cis rs7605827 0.897 rs6708187 chr2:15684964 T/A cg19274914 chr2:15703543 NA 0.38 5.8 0.3 1.59e-8 Educational attainment (years of education); CRC cis rs7512552 0.839 rs12042229 chr1:150447398 A/G cg15654264 chr1:150340011 RPRD2 0.6 8.38 0.42 1.59e-15 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); CRC cis rs10504229 0.596 rs6991216 chr8:58115586 T/C cg02725872 chr8:58115012 NA -0.64 -11.55 -0.54 3.85e-26 Developmental language disorder (linguistic errors); CRC cis rs4253772 0.530 rs11090865 chr22:46731689 G/T cg24881330 chr22:46731750 TRMU 0.63 6.5 0.34 2.99e-10 LDL cholesterol;Cholesterol, total; CRC cis rs4319547 0.915 rs7314638 chr12:122983460 A/G cg05707623 chr12:122985044 ZCCHC8 -0.8 -9.97 -0.48 1.28e-20 Body mass index; CRC cis rs1355223 0.506 rs1509659 chr11:34865133 A/G cg11058730 chr11:34937778 PDHX;APIP -0.43 -6.07 -0.32 3.52e-9 Systemic lupus erythematosus and Systemic sclerosis; CRC cis rs860295 0.702 rs34620961 chr1:155649827 G/C cg02153340 chr1:155202674 NA -0.58 -6.97 -0.36 1.7e-11 Body mass index; CRC cis rs7945705 0.840 rs10840136 chr11:8885024 C/T cg12365402 chr11:9010492 NRIP3 -0.51 -9.1 -0.45 8.74e-18 Hemoglobin concentration; CRC cis rs7412746 0.658 rs11204750 chr1:150939744 C/A cg10589385 chr1:150898437 SETDB1 0.33 6.98 0.36 1.68e-11 Melanoma; CRC cis rs6988985 0.728 rs1134095 chr8:143954290 A/G cg10324643 chr8:143916377 GML -0.34 -5.65 -0.3 3.55e-8 Plasma androstenedione levels in resected early stage-receptor positive breast cancer; CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg07590406 chr3:58292066 RPP14 -0.56 -6.93 -0.36 2.18e-11 Diisocyanate-induced asthma; CRC cis rs12701220 0.947 rs1007765 chr7:1032805 G/C cg26769984 chr7:1090371 C7orf50 0.63 8.24 0.41 4.14e-15 Bronchopulmonary dysplasia; CRC cis rs2836974 0.931 rs12151994 chr21:40690397 A/C cg17971929 chr21:40555470 PSMG1 0.75 10.32 0.49 7.97e-22 Cognitive function; CRC cis rs9322193 0.961 rs4870144 chr6:149896676 C/G cg00933542 chr6:150070202 PCMT1 0.3 6.1 0.32 2.9e-9 Lung cancer; CRC cis rs10242455 0.571 rs41258334 chr7:99271808 T/C cg18809830 chr7:99032528 PTCD1 -1.12 -8.14 -0.41 7.97e-15 Blood metabolite levels; CRC trans rs7647973 0.626 rs9870858 chr3:49769071 C/T cg21659725 chr3:3221576 CRBN -0.66 -7.53 -0.38 4.98e-13 Menarche (age at onset); CRC cis rs6693567 0.507 rs4970964 chr1:150458029 A/G cg15654264 chr1:150340011 RPRD2 0.4 5.98 0.31 5.72e-9 Migraine; CRC cis rs2732480 0.577 rs2732479 chr12:48736260 A/C cg24011408 chr12:48396354 COL2A1 0.47 6.39 0.33 5.64e-10 Hemoglobin concentration;Red blood cell count;Hematocrit; CRC cis rs1552244 0.872 rs6792951 chr3:10119603 C/A cg18598329 chr3:10140678 FANCD2;C3orf24 -0.88 -12.4 -0.56 3.16e-29 Alzheimer's disease; CRC cis rs11229555 0.645 rs11530830 chr11:58252992 C/G cg15696309 chr11:58395628 NA 0.85 10.75 0.51 2.7e-23 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; CRC cis rs929354 0.742 rs6956046 chr7:156962874 G/A cg17757837 chr7:157058334 UBE3C 0.74 12.39 0.56 3.31e-29 Body mass index; CRC cis rs2180341 1.000 rs6910763 chr6:127630925 T/C cg24812749 chr6:127587940 RNF146 0.95 13.71 0.6 3.81e-34 Breast cancer; CRC cis rs12760731 0.777 rs6701080 chr1:178382261 A/C cg00404053 chr1:178313656 RASAL2 1.16 11.74 0.54 8.13e-27 Obesity-related traits; CRC cis rs6066835 1.000 rs6066832 chr20:47354132 C/A cg18078177 chr20:47281410 PREX1 0.63 5.78 0.3 1.7e-8 Multiple myeloma; CRC cis rs776905 0.598 rs561241 chr13:113760034 T/C cg09069900 chr13:113776964 F10 -0.49 -7.45 -0.38 8.3e-13 Blood protein levels; CRC cis rs992157 0.835 rs7559416 chr2:219150211 A/G cg04731861 chr2:219085781 ARPC2 0.3 6.29 0.33 1.01e-9 Colorectal cancer; CRC cis rs13256369 1.000 rs12550458 chr8:8567832 G/A cg00074818 chr8:8560427 CLDN23 0.41 7.36 0.38 1.44e-12 Obesity-related traits; CRC cis rs8031584 0.578 rs1088473 chr15:31139298 A/G cg08704250 chr15:31115839 NA 0.56 9.87 0.48 2.67e-20 Huntington's disease progression; CRC trans rs11581859 0.950 rs7529415 chr1:99370765 C/G cg12183875 chr3:169587454 LRRC31 -0.27 -6.29 -0.33 1e-9 Response to cognitive-behavioural therapy in anxiety disorder; CRC cis rs7618915 0.501 rs62253740 chr3:52684128 A/T cg18404041 chr3:52824283 ITIH1 -0.41 -8.65 -0.43 2.39e-16 Bipolar disorder; CRC cis rs9372498 0.536 rs9481825 chr6:118876092 C/T cg15382696 chr6:118971807 C6orf204 0.6 7.95 0.4 3.06e-14 Diastolic blood pressure; CRC cis rs9388451 0.868 rs10457467 chr6:126045148 T/A cg10911889 chr6:126070802 HEY2 0.38 5.68 0.3 3.03e-8 Brugada syndrome; CRC cis rs7208859 0.623 rs56325146 chr17:29151024 T/C cg01831904 chr17:28903510 LRRC37B2 -0.6 -6.27 -0.33 1.11e-9 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs12745968 0.589 rs10782937 chr1:93103201 T/C cg17283838 chr1:93427260 FAM69A -0.48 -6.46 -0.34 3.87e-10 Bipolar disorder and schizophrenia; CRC cis rs7618915 0.571 rs17264436 chr3:52610651 T/A cg11645453 chr3:52864694 ITIH4 0.35 6.11 0.32 2.81e-9 Bipolar disorder; CRC cis rs7666738 0.830 rs13147768 chr4:98833675 A/T cg17366294 chr4:99064904 C4orf37 0.43 6.87 0.35 3.26e-11 Colonoscopy-negative controls vs population controls; CRC cis rs7617773 0.779 rs9833309 chr3:48327450 C/T cg11946769 chr3:48343235 NME6 0.64 8.85 0.44 5.61e-17 Coronary artery disease; CRC trans rs12599106 0.792 rs11648801 chr16:34360980 C/T cg03395511 chr6:291903 DUSP22 -0.51 -6.91 -0.36 2.53e-11 Menopause (age at onset); CRC cis rs908922 0.605 rs3753448 chr1:152486407 A/C cg09873164 chr1:152488093 CRCT1 0.36 5.92 0.31 7.89e-9 Hair morphology; CRC cis rs6502050 0.835 rs7219138 chr17:80079896 C/T cg13198984 chr17:80129470 CCDC57 -0.48 -8.58 -0.43 3.8e-16 Life satisfaction; CRC cis rs9491140 0.539 rs11154232 chr6:124691494 G/A cg19267163 chr6:125004984 NKAIN2 0.54 6.89 0.35 2.9e-11 Neuroticism; CRC trans rs783540 0.934 rs36109438 chr15:83264459 T/G cg18393722 chr15:85113863 UBE2QP1 -0.38 -6.43 -0.33 4.53e-10 Schizophrenia; CRC cis rs4713118 0.662 rs156744 chr6:27967274 G/A cg03623178 chr6:28175578 NA 0.87 12.94 0.58 2.98e-31 Parkinson's disease; CRC cis rs9902453 0.584 rs3809790 chr17:27955540 C/T cg26525008 chr17:28256777 EFCAB5;SSH2 -0.54 -8.13 -0.41 9.12e-15 Coffee consumption (cups per day); CRC cis rs6456156 0.586 rs13195158 chr6:167481392 G/A cg07741184 chr6:167504864 NA 0.38 6.59 0.34 1.71e-10 Primary biliary cholangitis; CRC cis rs6582630 0.519 rs8186881 chr12:38310285 A/G cg13010199 chr12:38710504 ALG10B 0.45 6.1 0.32 2.91e-9 Drug-induced liver injury (flucloxacillin); CRC cis rs6088590 0.735 rs6060001 chr20:33294353 C/T cg08999081 chr20:33150536 PIGU -0.52 -9.26 -0.45 2.63e-18 Coronary artery disease; CRC cis rs1572438 0.931 rs9406099 chr6:867030 A/G cg13447295 chr6:887704 NA -0.47 -6.84 -0.35 3.98e-11 Aging; CRC cis rs6912958 0.728 rs6923230 chr6:88213949 T/C cg12350822 chr6:88032061 C6orf162;GJB7 -0.34 -6.4 -0.33 5.41e-10 Monocyte percentage of white cells; CRC cis rs13315871 0.929 rs13066351 chr3:58398215 C/T cg20936604 chr3:58311152 NA -0.77 -7.28 -0.37 2.55e-12 Cholesterol, total; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg26743555 chr16:67194948 TRADD;FBXL8 0.43 6.02 0.31 4.7e-9 Response to antipsychotic treatment; CRC cis rs7512552 0.839 rs1694362 chr1:150366963 T/A cg15654264 chr1:150340011 RPRD2 0.6 8.44 0.42 1.02e-15 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); CRC cis rs16867335 1.000 rs76934807 chr2:181488585 T/A cg23363182 chr2:181467187 NA -0.5 -6.38 -0.33 6.18e-10 Survival in rectal cancer; CRC trans rs469722 0.965 rs32238 chr5:127693525 A/C cg14939821 chr10:128947230 DOCK1;FAM196A -0.31 -6.46 -0.34 3.74e-10 Cancer; CRC cis rs17270561 0.609 rs4711097 chr6:25732314 C/T cg17691542 chr6:26056736 HIST1H1C 0.73 9.28 0.46 2.3e-18 Iron status biomarkers; CRC cis rs28386778 0.897 rs2584639 chr17:61863732 C/T cg23090583 chr17:61904693 PSMC5;FTSJ3 1.05 20.71 0.75 1.47e-61 Prudent dietary pattern; CRC cis rs89107 0.576 rs4307206 chr6:118813320 A/C cg15382696 chr6:118971807 C6orf204 0.36 5.7 0.3 2.71e-8 Cardiac structure and function; CRC cis rs11190604 0.767 rs79106148 chr10:102184732 G/A cg16342193 chr10:102329863 NA -0.37 -6.0 -0.31 5.3300000000000004e-09 Palmitoleic acid (16:1n-7) levels; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg07394347 chr3:37285773 GOLGA4 0.47 6.72 0.35 7.98e-11 Response to antipsychotic treatment; CRC trans rs208520 0.690 rs851459 chr6:66813989 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.08 -15.42 -0.65 9.04e-41 Exhaled nitric oxide output; CRC trans rs2797160 1.000 rs6927161 chr6:126015954 T/C cg05039488 chr6:79577232 IRAK1BP1 0.51 7.59 0.39 3.37e-13 Endometrial cancer; CRC cis rs7605827 0.930 rs11681044 chr2:15717058 G/A cg19274914 chr2:15703543 NA 0.39 5.88 0.31 1.02e-8 Educational attainment (years of education); CRC cis rs2836974 0.897 rs1571709 chr21:40553980 T/C cg17971929 chr21:40555470 PSMG1 0.86 12.98 0.58 2.24e-31 Cognitive function; CRC cis rs3772130 0.962 rs11719093 chr3:121487686 G/A cg20356878 chr3:121714668 ILDR1 0.52 7.99 0.4 2.31e-14 Cognitive performance; CRC cis rs28386778 0.897 rs896064 chr17:61860932 C/T cg06873352 chr17:61820015 STRADA 0.8 15.29 0.64 2.98e-40 Prudent dietary pattern; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg25381775 chr1:6259495 RPL22 0.37 6.01 0.31 5.03e-9 Liver disease severity in Alagille syndrome; CRC cis rs9649213 0.593 rs55825602 chr7:98013039 T/C cg21770322 chr7:97807741 LMTK2 0.52 8.59 0.43 3.48e-16 Prostate cancer (SNP x SNP interaction); CRC cis rs7412746 0.658 rs897815 chr1:150879101 C/T cg18016565 chr1:150552671 MCL1 -0.4 -5.7 -0.3 2.66e-8 Melanoma; CRC cis rs34172651 0.917 rs200538 chr16:24735736 C/T cg00339695 chr16:24857497 SLC5A11 -0.26 -6.17 -0.32 2.02e-9 Intelligence (multi-trait analysis); CRC cis rs891088 0.614 rs41315074 chr19:7184243 C/G cg00428638 chr19:7224713 INSR -0.54 -5.78 -0.3 1.7e-8 Hip circumference adjusted for BMI;Height; CRC cis rs73206853 0.620 rs73194023 chr12:111137940 G/A cg12870014 chr12:110450643 ANKRD13A 0.76 6.49 0.34 3.24e-10 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC cis rs10504229 0.775 rs17805146 chr8:58161484 G/A cg21724239 chr8:58056113 NA 0.65 8.51 0.42 6.42e-16 Developmental language disorder (linguistic errors); CRC cis rs7811142 0.830 rs6979910 chr7:99940630 A/C cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.64 8.42 0.42 1.18e-15 Platelet count; CRC cis rs10504229 0.728 rs78765835 chr8:58154337 A/G cg22535103 chr8:58192502 C8orf71 -0.68 -8.37 -0.42 1.72e-15 Developmental language disorder (linguistic errors); CRC cis rs9462027 0.628 rs2814991 chr6:34615443 A/G cg07306190 chr6:34760872 UHRF1BP1 -0.35 -6.23 -0.32 1.41e-9 Systemic lupus erythematosus; CRC cis rs9911578 0.933 rs11868348 chr17:57179238 C/T cg05425664 chr17:57184151 TRIM37 -0.52 -8.15 -0.41 7.64e-15 Intelligence (multi-trait analysis); CRC cis rs6860806 0.631 rs7736284 chr5:131588151 T/C cg20512303 chr5:131592959 PDLIM4 0.36 6.77 0.35 6.09e-11 Breast cancer; CRC cis rs7212590 0.748 rs8074176 chr17:57861995 G/A cg10252138 chr17:58120427 NA -0.55 -5.98 -0.31 5.93e-9 Granulocyte percentage of myeloid white cells;Monocyte count;Monocyte percentage of white cells; CRC cis rs7727544 0.836 rs10463892 chr5:131598705 T/C cg04518342 chr5:131593106 PDLIM4 0.36 6.78 0.35 5.52e-11 Blood metabolite levels; CRC cis rs3823572 0.504 rs2953633 chr7:133644052 A/C cg03336402 chr7:133662267 EXOC4 -0.66 -10.28 -0.49 1.14e-21 Intelligence (multi-trait analysis); CRC cis rs35306767 0.855 rs12761180 chr10:872086 C/T cg20503657 chr10:835505 NA 1.23 15.05 0.64 2.68e-39 Eosinophil percentage of granulocytes; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg16229772 chr11:535615 HRAS 0.43 6.37 0.33 6.23e-10 Response to antipsychotic treatment; CRC cis rs9611565 0.546 rs739132 chr22:42123099 A/T cg03806693 chr22:41940476 POLR3H 1.06 13.33 0.59 1.06e-32 Vitiligo; CRC cis rs17713451 0.593 rs78218801 chr7:151269007 G/A cg18404559 chr7:151322523 PRKAG2 -0.57 -6.41 -0.33 5.12e-10 Interleukin-4 levels; CRC cis rs6541297 1.000 rs6665367 chr1:230279169 G/A cg05784532 chr1:230284198 GALNT2 0.44 6.19 0.32 1.75e-9 Coronary artery disease; CRC cis rs9858542 0.953 rs11922013 chr3:49458355 G/C cg07274523 chr3:49395745 GPX1 0.46 6.27 0.33 1.11e-9 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs10540 0.558 rs12806062 chr11:501429 G/A cg19913688 chr11:428466 ANO9 -0.7 -6.88 -0.35 3.01e-11 Body mass index; CRC trans rs1455244 0.700 rs7229302 chr18:11508904 G/T cg02203542 chr20:305175 SOX12 0.42 6.17 0.32 1.99e-9 Schizophrenia; CRC cis rs9611565 0.879 rs2235845 chr22:41729294 T/G cg03806693 chr22:41940476 POLR3H -0.7 -10.11 -0.49 4.13e-21 Vitiligo; CRC cis rs6540559 0.673 rs41305104 chr1:209950848 G/A cg21951975 chr1:209979733 IRF6 0.47 5.62 0.3 4.05e-8 Cleft lip with or without cleft palate; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg21548116 chr4:100009993 ADH5 0.37 5.98 0.31 5.81e-9 Liver disease severity in Alagille syndrome; CRC cis rs10779751 1.000 rs6670821 chr1:11308762 T/C cg08854313 chr1:11322531 MTOR 0.68 9.63 0.47 1.72e-19 Body mass index; CRC cis rs4555082 0.874 rs2735828 chr14:105710486 C/A cg06808227 chr14:105710500 BRF1 -0.64 -9.66 -0.47 1.34e-19 Mean platelet volume;Platelet distribution width; CRC cis rs11792861 0.926 rs1051474 chr9:111881856 T/C cg05043794 chr9:111880884 C9orf5 -0.35 -6.33 -0.33 7.97e-10 Menarche (age at onset); CRC cis rs28386778 0.830 rs2597637 chr17:61875066 T/G cg06601766 chr17:61851465 DDX42;CCDC47 0.45 6.14 0.32 2.4e-9 Prudent dietary pattern; CRC trans rs1005277 0.579 rs1740747 chr10:38520465 G/A cg11292332 chr7:45801988 SEPT13 -0.39 -7.05 -0.36 1.05e-11 Extrinsic epigenetic age acceleration; CRC cis rs1008375 1.000 rs2315556 chr4:17670861 T/C cg16339924 chr4:17578868 LAP3 0.5 6.56 0.34 2.07e-10 Parasitemia in Tripanosoma cruzi seropositivity; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg26778029 chr7:74072136 GTF2I 0.41 6.05 0.32 4.05e-9 Liver disease severity in Alagille syndrome; CRC cis rs2836974 0.897 rs35064900 chr21:40555492 A/G cg11890956 chr21:40555474 PSMG1 1.13 21.01 0.76 9.76e-63 Cognitive function; CRC cis rs9322193 0.923 rs12174349 chr6:150039148 G/A cg00933542 chr6:150070202 PCMT1 0.29 5.96 0.31 6.41e-9 Lung cancer; CRC cis rs7215564 0.818 rs1531946 chr17:78630807 G/A cg09596252 chr17:78655493 RPTOR 0.6 5.63 0.3 3.79e-8 Myopia (pathological); CRC cis rs2415984 0.622 rs61993296 chr14:46934216 C/T cg14871534 chr14:47121158 RPL10L -0.44 -6.18 -0.32 1.86e-9 Number of children ever born; CRC cis rs9911578 0.803 rs8069033 chr17:57131581 T/A cg12560992 chr17:57184187 TRIM37 -0.94 -17.88 -0.7 2e-50 Intelligence (multi-trait analysis); CRC trans rs459571 0.715 rs401826 chr9:136890591 C/T cg09836344 chr4:1243392 C4orf42;CTBP1 -0.84 -11.81 -0.55 4.57e-27 Platelet distribution width; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg24704015 chr2:230931896 SLC16A14 0.42 6.64 0.34 1.3e-10 Liver disease severity in Alagille syndrome; CRC cis rs7731657 0.537 rs13355897 chr5:130360622 G/A cg08523029 chr5:130500466 HINT1 -0.45 -5.83 -0.31 1.3e-8 Fasting plasma glucose; CRC cis rs780096 0.526 rs780106 chr2:27681598 A/C cg27432699 chr2:27873401 GPN1 -0.52 -7.96 -0.4 2.91e-14 Total body bone mineral density; CRC trans rs634534 0.561 rs655744 chr11:65776585 G/T cg17712092 chr4:129076599 LARP1B -0.66 -10.7 -0.51 4.01e-23 Sum eosinophil basophil counts;Eosinophil counts; CRC cis rs1552244 1.000 rs7615764 chr3:10082592 C/T cg02579736 chr3:10068473 FANCD2;CIDECP 1.05 14.06 0.61 1.71e-35 Alzheimer's disease; CRC cis rs4727027 0.716 rs4727020 chr7:148837317 C/T cg12479418 chr7:148823350 ZNF425;ZNF398 0.49 6.39 0.33 5.77e-10 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC cis rs2066819 0.892 rs17118431 chr12:56667100 A/G cg26714650 chr12:56694279 CS -1.41 -11.64 -0.54 1.88e-26 Psoriasis vulgaris; CRC cis rs853679 1.000 rs6901575 chr6:28250984 G/A cg15845792 chr6:28175446 NA 0.67 6.68 0.35 9.96e-11 Depression; CRC cis rs769267 0.965 rs2965191 chr19:19453521 T/G cg03709012 chr19:19516395 GATAD2A -0.67 -10.31 -0.49 9.07e-22 Tonsillectomy; CRC cis rs9649465 0.967 rs12539091 chr7:123291314 C/T cg03229431 chr7:123269106 ASB15 -0.37 -5.67 -0.3 3.14e-8 Migraine; CRC cis rs9393777 0.528 rs7745603 chr6:27090404 C/T cg12292205 chr6:26970375 C6orf41 -0.67 -8.88 -0.44 4.26e-17 Intelligence (multi-trait analysis); CRC cis rs13256369 1.000 rs9329165 chr8:8576642 C/T cg06671706 chr8:8559999 CLDN23 -0.59 -8.74 -0.43 1.25e-16 Obesity-related traits; CRC trans rs2976388 0.609 rs2585148 chr8:143796193 C/G cg24628676 chr5:59189846 PDE4D -0.3 -6.08 -0.32 3.26e-9 Urinary tract infection frequency; CRC cis rs7503807 0.967 rs12939549 chr17:78611724 C/T cg09596252 chr17:78655493 RPTOR -0.39 -6.02 -0.32 4.6e-9 Obesity; CRC cis rs6502050 0.835 rs4789744 chr17:80101506 A/C cg13198984 chr17:80129470 CCDC57 0.46 8.16 0.41 6.94e-15 Life satisfaction; CRC cis rs13256369 1.000 rs13256369 chr8:8577379 T/C cg06671706 chr8:8559999 CLDN23 0.55 8.29 0.42 2.93e-15 Obesity-related traits; CRC cis rs11098499 0.505 rs75122014 chr4:120362426 G/C cg24375607 chr4:120327624 NA 0.51 7.98 0.4 2.49e-14 Corneal astigmatism; CRC cis rs10504229 0.683 rs67492041 chr8:58140077 G/A cg02290350 chr8:58132656 NA -0.58 -8.16 -0.41 7.29e-15 Developmental language disorder (linguistic errors); CRC cis rs72945132 0.882 rs7941933 chr11:70123351 G/A cg00319359 chr11:70116639 PPFIA1 0.67 6.98 0.36 1.6e-11 Coronary artery disease; CRC cis rs853679 0.574 rs1233705 chr6:28166447 C/G cg25164649 chr6:28176230 NA 0.79 11.08 0.52 1.9e-24 Depression; CRC cis rs11190604 1.000 rs9420782 chr10:102235015 G/A cg07080220 chr10:102295463 HIF1AN 0.46 5.8 0.3 1.53e-8 Palmitoleic acid (16:1n-7) levels; CRC cis rs73206853 0.640 rs3825390 chr12:110976409 A/C cg12870014 chr12:110450643 ANKRD13A 0.77 9.69 0.47 1.05e-19 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC cis rs798554 0.757 rs1182177 chr7:2874540 C/T cg17321639 chr7:2759063 NA -0.53 -7.04 -0.36 1.15e-11 Height; CRC cis rs736801 0.808 rs4705950 chr5:131793286 C/T cg00255919 chr5:131827918 IRF1 -0.37 -6.27 -0.33 1.11e-9 Breast cancer;Mosquito bite size; CRC cis rs4665809 0.590 rs13016300 chr2:26468365 G/C cg22920501 chr2:26401640 FAM59B 0.83 11.96 0.55 1.28e-27 Gut microbiome composition (summer); CRC cis rs6582630 0.519 rs11514056 chr12:38284001 G/T cg13010199 chr12:38710504 ALG10B 0.45 5.95 0.31 6.72e-9 Drug-induced liver injury (flucloxacillin); CRC cis rs801193 0.569 rs35070132 chr7:66238083 C/T cg18252515 chr7:66147081 NA -0.44 -6.27 -0.33 1.15e-9 Aortic root size; CRC cis rs11190604 0.767 rs10883481 chr10:102165021 G/A cg16342193 chr10:102329863 NA -0.35 -5.62 -0.3 4e-8 Palmitoleic acid (16:1n-7) levels; CRC cis rs9372498 0.536 rs77435770 chr6:118819467 G/A cg18833306 chr6:118973337 C6orf204 0.45 6.01 0.31 4.81e-9 Diastolic blood pressure; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg16669491 chr19:19314215 NR2C2AP 0.49 6.85 0.35 3.62e-11 Response to antipsychotic treatment; CRC cis rs4665809 0.818 rs35413760 chr2:26267137 C/A cg27170947 chr2:26402098 FAM59B 0.49 5.65 0.3 3.42e-8 Gut microbiome composition (summer); CRC cis rs7619833 0.715 rs4973766 chr3:27413566 C/T cg02860705 chr3:27208620 NA 0.39 5.79 0.3 1.61e-8 Breast cancer; CRC cis rs2625529 0.652 rs2957724 chr15:72248474 A/C cg16672083 chr15:72433130 SENP8 0.48 7.18 0.37 4.56e-12 Red blood cell count; CRC cis rs1129187 0.686 rs6458313 chr6:42922018 A/G cg02353165 chr6:42928485 GNMT 0.71 11.61 0.54 2.4e-26 Alzheimer's disease in APOE e4+ carriers; CRC cis rs561341 1.000 rs56903735 chr17:30254393 T/A cg12193833 chr17:30244370 NA -0.59 -7.76 -0.39 1.06e-13 Hip circumference adjusted for BMI; CRC cis rs2404602 1.000 rs2896954 chr15:76851692 C/A cg23625390 chr15:77176239 SCAPER 0.63 9.87 0.48 2.75e-20 Blood metabolite levels; CRC cis rs6951245 0.872 rs75493422 chr7:1072890 C/T cg18402987 chr7:1209562 NA 0.64 6.78 0.35 5.72e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs4808199 0.739 rs2240117 chr19:19418916 C/T cg03709012 chr19:19516395 GATAD2A 0.96 9.4 0.46 9.63e-19 Nonalcoholic fatty liver disease; CRC cis rs7605827 0.897 rs6431698 chr2:15540156 G/C cg19274914 chr2:15703543 NA 0.39 5.9 0.31 8.79e-9 Educational attainment (years of education); CRC trans rs8073060 0.544 rs8071584 chr17:33999435 G/A cg19694781 chr19:47549865 TMEM160 -1.06 -15.04 -0.64 2.94e-39 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; CRC cis rs10540 1.000 rs78520676 chr11:517173 G/A cg08200582 chr11:442649 ANO9 -0.71 -7.33 -0.37 1.83e-12 Body mass index; CRC cis rs7804356 1.000 rs6461979 chr7:26888918 T/C cg03456212 chr7:26904342 SKAP2 -0.5 -5.69 -0.3 2.85e-8 Type 1 diabetes; CRC cis rs7617773 0.780 rs35297486 chr3:48378147 T/A cg11946769 chr3:48343235 NME6 0.76 10.09 0.49 5.05e-21 Coronary artery disease; CRC cis rs11997175 0.646 rs7464237 chr8:33716596 C/T cg04338863 chr8:33670619 NA 0.42 6.76 0.35 6.19e-11 Body mass index; CRC cis rs1448094 0.512 rs1584368 chr12:86245117 A/C cg19622623 chr12:86230825 RASSF9 -0.41 -6.77 -0.35 5.76e-11 Major depressive disorder; CRC cis rs1008375 0.966 rs2315553 chr4:17627332 T/C cg04450456 chr4:17643702 FAM184B 0.36 5.62 0.3 4.1e-8 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs7927771 0.832 rs4992357 chr11:47393638 C/T cg18512352 chr11:47633146 NA -0.33 -6.36 -0.33 6.65e-10 Subjective well-being; CRC cis rs7811142 0.830 rs10085549 chr7:99983135 C/T cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.88 11.91 0.55 1.9e-27 Platelet count; CRC cis rs6500602 0.727 rs4786509 chr16:4568769 C/G cg14951292 chr16:4525986 HMOX2;NMRAL1 -0.55 -8.3 -0.42 2.68e-15 Schizophrenia; CRC cis rs4743820 0.651 rs73494914 chr9:93923108 G/A cg14446406 chr9:93919335 NA 0.81 14.88 0.63 1.24e-38 Ulcerative colitis;Inflammatory bowel disease; CRC cis rs6484504 0.576 rs208090 chr11:31190992 T/C cg14844989 chr11:31128820 NA -0.34 -5.9 -0.31 9.08e-9 Red blood cell count; CRC trans rs561341 1.000 rs693116 chr17:30246124 C/T cg27661571 chr11:113659931 NA -0.96 -11.11 -0.52 1.42e-24 Hip circumference adjusted for BMI; CRC cis rs9322193 0.962 rs9322220 chr6:150104033 G/C cg13206674 chr6:150067644 NUP43 0.57 8.14 0.41 8.29e-15 Lung cancer; CRC cis rs367943 1.000 rs348963 chr5:112819027 A/G cg12552261 chr5:112820674 MCC -0.48 -7.44 -0.38 8.6e-13 Type 2 diabetes; CRC trans rs660498 0.785 rs9418630 chr10:27734215 G/A cg13661793 chr10:32399026 NA -0.33 -5.99 -0.31 5.51e-9 Asthma (childhood onset); CRC cis rs3751196 0.808 rs17034640 chr12:104218137 A/G cg02344784 chr12:104178138 NT5DC3 -0.65 -7.23 -0.37 3.4e-12 Sense of smell; CRC cis rs10193935 0.901 rs1390609 chr2:42666230 G/T cg27598129 chr2:42591480 NA 0.64 7.58 0.39 3.65e-13 Colonoscopy-negative controls vs population controls; CRC cis rs853679 0.517 rs12174753 chr6:28042465 C/G cg06470822 chr6:28175283 NA 0.98 13.09 0.59 8.7e-32 Depression; CRC cis rs13191362 0.507 rs13207363 chr6:163201285 C/G cg06582575 chr6:163149167 PACRG;PARK2 -0.5 -7.67 -0.39 1.92e-13 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs6570726 0.818 rs952405 chr6:145925952 T/C cg13319975 chr6:146136371 FBXO30 -0.41 -5.97 -0.31 6.28e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs6921919 0.583 rs740621 chr6:28397787 A/G cg21251018 chr6:28226885 NKAPL 0.39 5.94 0.31 7.39e-9 Autism spectrum disorder or schizophrenia; CRC cis rs11098499 0.779 rs7356491 chr4:120381974 C/T cg09307838 chr4:120376055 NA 0.71 11.02 0.52 3.08e-24 Corneal astigmatism; CRC cis rs6952808 0.501 rs4721429 chr7:2171704 T/C cg22963979 chr7:1858916 MAD1L1 -0.41 -5.84 -0.31 1.22e-8 Bipolar disorder and schizophrenia; CRC trans rs3749237 0.964 rs11717463 chr3:49808981 C/T cg21665057 chr3:196295764 WDR53;FBXO45 0.5 6.7 0.35 9.06e-11 Resting heart rate; CRC cis rs1403694 1.000 rs1403694 chr3:186439998 T/C cg04611788 chr3:186434169 KNG1 -0.46 -7.13 -0.37 6.6e-12 Blood protein levels; CRC cis rs7727544 0.904 rs6897575 chr5:131604535 C/T cg20512303 chr5:131592959 PDLIM4 0.29 5.69 0.3 2.87e-8 Blood metabolite levels; CRC cis rs1448094 0.512 rs7308229 chr12:86239849 A/T cg02569458 chr12:86230093 RASSF9 -0.43 -7.19 -0.37 4.49e-12 Major depressive disorder; CRC cis rs6456156 0.526 rs3093025 chr6:167532731 A/G cg19688584 chr6:167529678 CCR6 -0.32 -5.73 -0.3 2.25e-8 Primary biliary cholangitis; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg01747036 chr13:113140125 TUBGCP3 -0.39 -6.04 -0.32 4.1e-9 Liver disease severity in Alagille syndrome; CRC cis rs727563 0.638 rs4820443 chr22:42193913 A/G cg06481639 chr22:41940642 POLR3H -0.51 -5.84 -0.31 1.26e-8 Crohn's disease;Inflammatory bowel disease; CRC trans rs2898857 0.504 rs12937923 chr17:47408475 G/A cg11430096 chr6:110968061 CDK19 -0.49 -7.43 -0.38 9.2e-13 Cancer; CRC trans rs2303319 0.504 rs961421 chr2:162626099 G/C cg04551154 chr10:95462393 C10orf4 -0.74 -6.34 -0.33 7.76e-10 Cognitive function; CRC cis rs11676348 0.846 rs13009946 chr2:219007752 A/C cg00012203 chr2:219082015 ARPC2 -0.44 -6.73 -0.35 7.71e-11 Ulcerative colitis; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg11797222 chr15:66679417 MAP2K1 0.4 6.11 0.32 2.8e-9 Liver disease severity in Alagille syndrome; CRC trans rs2303319 0.504 rs72877343 chr2:162607487 A/C cg04551154 chr10:95462393 C10orf4 -0.75 -6.37 -0.33 6.43e-10 Cognitive function; CRC cis rs1506636 1.000 rs7779099 chr7:123295964 C/T cg03229431 chr7:123269106 ASB15 -0.78 -12.46 -0.57 1.92e-29 Plateletcrit;Platelet count; CRC cis rs2985684 0.894 rs8005990 chr14:50022248 G/A cg23565292 chr14:50234668 KLHDC2 -0.4 -5.7 -0.3 2.66e-8 Carotid intima media thickness; CRC cis rs1707322 1.000 rs10890378 chr1:46410657 A/G cg03146154 chr1:46216737 IPP -0.51 -7.08 -0.36 8.59e-12 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC trans rs8123881 0.733 rs7268466 chr20:15810676 C/T cg03070588 chr12:109490239 USP30 0.56 5.98 0.31 5.7e-9 Body mass index; CRC cis rs526821 0.595 rs608964 chr11:55339266 G/A cg04317927 chr11:55418816 OR4S2 0.39 6.6 0.34 1.68e-10 Pediatric bone mineral density (spine); CRC cis rs6694672 1.000 rs9427657 chr1:196943321 A/G cg13682187 chr1:196946512 CFHR5 -0.47 -6.99 -0.36 1.56e-11 Asthma; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg01796184 chr1:200708096 CAMSAP1L1 0.47 6.66 0.34 1.16e-10 Response to antipsychotic treatment; CRC cis rs6582630 0.539 rs35114325 chr12:38320886 G/T cg13010199 chr12:38710504 ALG10B -0.4 -5.76 -0.3 1.89e-8 Drug-induced liver injury (flucloxacillin); CRC trans rs1814175 0.935 rs7482690 chr11:49648814 C/T cg15704280 chr7:45808275 SEPT13 -0.97 -17.87 -0.7 2.13e-50 Height; CRC cis rs6502050 0.777 rs6502058 chr17:80082500 A/C cg13198984 chr17:80129470 CCDC57 -0.48 -8.56 -0.43 4.49e-16 Life satisfaction; CRC cis rs6921919 0.848 rs6903823 chr6:28322296 A/G cg21251018 chr6:28226885 NKAPL 0.41 5.78 0.3 1.74e-8 Autism spectrum disorder or schizophrenia; CRC cis rs2836974 0.583 rs9636957 chr21:40705847 G/A cg11644478 chr21:40555479 PSMG1 -0.63 -9.83 -0.48 3.76e-20 Cognitive function; CRC trans rs10021731 0.692 rs11722162 chr4:115411616 C/T cg25927708 chr2:119603813 EN1 -0.33 -6.01 -0.31 4.92e-9 Optic disc area; CRC cis rs8105895 0.778 rs10401922 chr19:22253252 T/A cg02657401 chr19:22469223 NA -0.34 -5.65 -0.3 3.56e-8 Body mass index (change over time); CRC cis rs12474201 0.925 rs17822294 chr2:46960004 G/A cg06386533 chr2:46925753 SOCS5 0.81 13.5 0.6 2.34e-33 Height; CRC cis rs13082711 0.595 rs17317435 chr3:27339326 A/G cg02860705 chr3:27208620 NA 0.76 10.2 0.49 2.11e-21 Systolic blood pressure;Diastolic blood pressure;Blood pressure; CRC cis rs3106136 1.000 rs2632401 chr4:95147055 C/G cg11021082 chr4:95130006 SMARCAD1 0.47 7.31 0.37 2.04e-12 Capecitabine sensitivity; CRC cis rs2559856 0.967 rs2559863 chr12:102087108 C/T cg12924262 chr12:102091054 CHPT1 0.55 8.13 0.41 9.12e-15 Blood protein levels; CRC cis rs2204008 0.627 rs10878488 chr12:38148666 G/A cg26384229 chr12:38710491 ALG10B 0.71 9.43 0.46 7.56e-19 Bladder cancer; CRC trans rs8002861 0.967 rs9525871 chr13:44477712 A/T cg17145862 chr1:211918768 LPGAT1 0.77 15.53 0.65 3.57e-41 Leprosy; CRC cis rs6121246 0.954 rs6060978 chr20:30416893 G/A cg13852791 chr20:30311386 BCL2L1 0.61 9.7 0.47 9.88e-20 Mean corpuscular hemoglobin; CRC cis rs11098499 0.648 rs2002047 chr4:120257228 A/G cg09307838 chr4:120376055 NA 0.62 9.63 0.47 1.68e-19 Corneal astigmatism; CRC cis rs9487051 0.752 rs9372209 chr6:109601684 T/C cg21918786 chr6:109611834 NA -0.42 -7.3 -0.37 2.15e-12 Reticulocyte fraction of red cells; CRC cis rs12936587 0.569 rs8073683 chr17:17555596 C/T cg09796270 chr17:17721594 SREBF1 -0.45 -7.54 -0.38 4.74e-13 Hip circumference;Coronary artery disease or large artery stroke;Coronary heart disease;Coronary artery disease; CRC cis rs7258465 1.000 rs4808134 chr19:18608579 G/A cg06462663 chr19:18546047 ISYNA1 0.46 7.07 0.36 9.28e-12 Breast cancer; CRC cis rs523522 0.962 rs11065145 chr12:120947419 A/G cg27279351 chr12:120934652 DYNLL1 0.78 11.48 0.53 7.05e-26 High light scatter reticulocyte count; CRC cis rs10256972 0.681 rs12702016 chr7:1129392 C/T cg16145915 chr7:1198662 ZFAND2A -0.4 -7.79 -0.39 8.68e-14 Longevity;Endometriosis; CRC cis rs10540 1.000 rs61877760 chr11:506596 C/T cg21784768 chr11:537496 LRRC56 -0.7 -6.67 -0.35 1.07e-10 Body mass index; CRC cis rs11148252 0.846 rs7333451 chr13:53047709 G/A cg00495681 chr13:53174319 NA 0.58 8.77 0.44 1.01e-16 Lewy body disease; CRC cis rs28386778 0.897 rs2028567 chr17:61915326 G/A cg23090583 chr17:61904693 PSMC5;FTSJ3 1.05 20.14 0.74 2.41e-59 Prudent dietary pattern; CRC cis rs4819052 0.851 rs28676615 chr21:46676576 G/C cg19498844 chr21:46707878 POFUT2;LOC642852 0.78 11.23 0.53 5.38e-25 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs796364 1.000 rs281760 chr2:200787804 A/G cg23649088 chr2:200775458 C2orf69 0.55 6.01 0.31 4.94e-9 Schizophrenia; CRC cis rs10751667 0.857 rs7481221 chr11:966813 G/C cg06064525 chr11:970664 AP2A2 -0.3 -6.11 -0.32 2.78e-9 Alzheimer's disease (late onset); CRC cis rs7605827 0.893 rs7575722 chr2:15597551 G/A cg19274914 chr2:15703543 NA 0.39 5.96 0.31 6.58e-9 Educational attainment (years of education); CRC cis rs780096 0.527 rs59644396 chr2:27646083 A/G cg27432699 chr2:27873401 GPN1 -0.52 -7.99 -0.4 2.24e-14 Total body bone mineral density; CRC cis rs936229 0.861 rs12441505 chr15:75107311 A/C cg14664628 chr15:75095509 CSK -1.02 -20.56 -0.75 5.24e-61 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); CRC cis rs2066819 1.000 rs2695782 chr12:56722830 C/T cg26734620 chr12:56694298 CS -0.62 -5.93 -0.31 7.84e-9 Psoriasis vulgaris; CRC cis rs40363 0.645 rs4786421 chr16:3522303 A/G cg22508957 chr16:3507546 NAT15 -0.61 -9.99 -0.48 1.08e-20 Tuberculosis; CRC cis rs17345786 1.000 rs3762729 chr3:101308874 C/T cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.58 6.81 0.35 4.57e-11 Colonoscopy-negative controls vs population controls; CRC cis rs10504229 0.683 rs17194487 chr8:58104912 C/T cg08219700 chr8:58056026 NA 0.55 6.47 0.34 3.59e-10 Developmental language disorder (linguistic errors); CRC cis rs311392 0.525 rs2013503 chr8:55104343 C/T cg06042504 chr8:55087323 NA -0.36 -5.76 -0.3 1.95e-8 Pelvic organ prolapse (moderate/severe); CRC cis rs9291683 0.575 rs3756223 chr4:10105797 C/T cg00071950 chr4:10020882 SLC2A9 0.39 6.54 0.34 2.37e-10 Bone mineral density; CRC cis rs7680126 0.596 rs4698032 chr4:10316582 T/G cg11266682 chr4:10021025 SLC2A9 -0.38 -5.79 -0.3 1.6e-8 Urate levels in lean individuals;Urate levels in overweight individuals;Urate levels in obese individuals; CRC trans rs3780486 0.846 rs7864705 chr9:33140352 A/C cg04842962 chr6:43655489 MRPS18A 1.17 25.75 0.82 7.25e-81 IgG glycosylation; CRC trans rs57221529 0.709 rs111352378 chr5:577079 G/A cg25482853 chr8:67687455 SGK3 1.25 14.99 0.64 4.45e-39 Lung disease severity in cystic fibrosis; CRC cis rs9297145 0.761 rs28545226 chr7:98732472 A/T cg05967295 chr7:98741636 SMURF1 1.12 16.54 0.67 3.97e-45 Crohn's disease;Inflammatory bowel disease;Ulcerative colitis; CRC cis rs7149337 0.773 rs3007067 chr14:51596420 G/A cg18683604 chr14:51561293 TRIM9 0.3 6.11 0.32 2.84e-9 Cancer; CRC cis rs3796352 1.000 rs71299622 chr3:52917038 G/A cg07884673 chr3:53033167 SFMBT1 0.81 6.37 0.33 6.5e-10 Immune reponse to smallpox (secreted IL-2); CRC cis rs55788414 0.932 rs8048115 chr16:81182554 T/C cg06400318 chr16:81190750 PKD1L2 -0.59 -6.78 -0.35 5.73e-11 Left ventricular obstructive tract defect (maternal effect); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg02060698 chr6:108881455 FOXO3 0.47 6.63 0.34 1.38e-10 Response to antipsychotic treatment; CRC cis rs8038465 0.594 rs55816897 chr15:73869767 G/T cg15420318 chr15:73925796 NPTN 0.46 7.54 0.38 4.63e-13 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs12681287 0.640 rs7832493 chr8:87371533 A/C cg27223183 chr8:87520930 FAM82B 0.53 7.19 0.37 4.51e-12 Caudate activity during reward; CRC cis rs796364 0.806 rs11689664 chr2:201099961 A/G cg25936922 chr2:200820526 C2orf60;C2orf47 -0.61 -5.67 -0.3 3.07e-8 Schizophrenia; CRC cis rs769267 0.930 rs3794990 chr19:19610030 A/G cg01262667 chr19:19385393 TM6SF2 0.36 5.87 0.31 1.06e-8 Tonsillectomy; CRC cis rs7552404 0.696 rs10518521 chr1:76461214 G/A cg03433033 chr1:76189801 ACADM 0.71 7.97 0.4 2.64e-14 Blood metabolite levels;Acylcarnitine levels; CRC cis rs11577318 0.853 rs11803933 chr1:26629465 G/C cg00852783 chr1:26633632 UBXN11 0.47 6.76 0.35 6.21e-11 Granulocyte percentage of myeloid white cells; CRC cis rs9487051 0.872 rs9480922 chr6:109607211 G/A cg12927641 chr6:109611667 NA -0.39 -7.0 -0.36 1.45e-11 Reticulocyte fraction of red cells; CRC cis rs763121 0.853 rs8140617 chr22:38970439 A/G cg06544989 chr22:39130855 UNC84B -0.43 -6.32 -0.33 8.67e-10 Menopause (age at onset); CRC trans rs1814175 0.817 rs4881623 chr11:49804991 C/T cg11707556 chr5:10655725 ANKRD33B -0.43 -8.23 -0.41 4.56e-15 Height; CRC cis rs9910055 0.529 rs575798 chr17:42181796 A/C cg19774624 chr17:42201019 HDAC5 0.45 5.86 0.31 1.13e-8 Total body bone mineral density; CRC cis rs12681288 0.823 rs2701909 chr8:1003057 A/G cg15309053 chr8:964076 NA 0.34 6.03 0.32 4.44e-9 Schizophrenia; CRC cis rs6860806 0.531 rs2631359 chr5:131707892 C/T cg22638593 chr5:131593259 PDLIM4 -0.38 -6.32 -0.33 8.68e-10 Breast cancer; CRC cis rs2836974 0.644 rs4818017 chr21:40690561 G/T cg11890956 chr21:40555474 PSMG1 -0.81 -12.8 -0.58 1.02e-30 Cognitive function; CRC cis rs4148883 0.675 rs10000357 chr4:100099942 G/C cg12011299 chr4:100065546 ADH4 0.5 10.97 0.52 4.61e-24 Alcohol dependence; CRC cis rs9916302 0.904 rs34363096 chr17:37594294 G/A cg07936489 chr17:37558343 FBXL20 -0.85 -13.35 -0.59 8.55e-33 Glomerular filtration rate (creatinine); CRC cis rs7474896 0.522 rs117157955 chr10:37984164 G/T cg25427524 chr10:38739819 LOC399744 -0.6 -7.41 -0.38 1.06e-12 Obesity (extreme); CRC cis rs7089973 0.872 rs7918253 chr10:116614501 T/C cg03647239 chr10:116582469 FAM160B1 0.41 5.72 0.3 2.37e-8 Bipolar disorder or attention deficit hyperactivity disorder; CRC cis rs6456156 0.586 rs1358882 chr6:167467101 G/A cg07741184 chr6:167504864 NA 0.39 6.84 0.35 3.91e-11 Primary biliary cholangitis; CRC trans rs62103177 0.608 rs613847 chr18:77845644 A/G cg05926928 chr17:57297772 GDPD1 -0.58 -6.0 -0.31 5.11e-9 Opioid sensitivity; CRC cis rs9650315 0.530 rs68005065 chr8:57090308 C/A cg23139584 chr8:56987506 RPS20;SNORD54 0.45 6.29 0.33 9.96e-10 Height; CRC cis rs524023 0.958 rs3825016 chr11:64359286 C/T cg06522879 chr11:64358276 SLC22A12 -0.59 -9.38 -0.46 1.11e-18 Urate levels in obese individuals; CRC cis rs3820068 0.580 rs12746773 chr1:16001588 C/T cg27534772 chr1:16042836 PLEKHM2 0.56 10.79 0.51 1.98e-23 Systolic blood pressure; CRC cis rs11583043 1.000 rs12750667 chr1:101498682 A/G cg16556008 chr1:101360663 SLC30A7;EXTL2 0.46 5.89 0.31 9.3e-9 Ulcerative colitis;Inflammatory bowel disease; CRC cis rs60843830 1.000 rs3791220 chr2:227066 C/T cg25945732 chr2:264204 ACP1;SH3YL1 0.73 12.11 0.56 3.74e-28 Spherical equivalent (joint analysis main effects and education interaction); CRC cis rs4437462 0.945 rs16871246 chr6:11312080 G/A cg25250968 chr6:11318770 NEDD9 -0.4 -5.86 -0.31 1.1e-8 HIV-1 susceptibility; CRC cis rs10504229 0.953 rs57131327 chr8:58171895 T/C cg01721255 chr8:58191610 C8orf71 0.49 6.17 0.32 2e-9 Developmental language disorder (linguistic errors); CRC cis rs9916302 0.904 rs2061338 chr17:37421767 T/C cg15445000 chr17:37608096 MED1 0.42 9.18 0.45 4.89e-18 Glomerular filtration rate (creatinine); CRC cis rs9788682 1.000 rs7181447 chr15:78814567 A/G cg06917634 chr15:78832804 PSMA4 -0.48 -5.89 -0.31 9.37e-9 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; CRC cis rs6840360 0.967 rs6841204 chr4:152598603 C/T cg09659197 chr4:152720779 NA 0.52 11.24 0.53 4.87e-25 Intelligence (multi-trait analysis); CRC cis rs56114371 0.530 rs9357045 chr6:27688927 G/A cg03623178 chr6:28175578 NA 0.53 6.1 0.32 2.94e-9 Breast cancer; CRC cis rs9291683 0.546 rs7442336 chr4:10045783 G/A cg11266682 chr4:10021025 SLC2A9 0.52 10.62 0.51 7.35e-23 Bone mineral density; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg11237535 chr17:78075184 GAA 0.47 6.64 0.34 1.3100000000000001e-10 Anxiety disorder; CRC cis rs10791323 0.569 rs1119852 chr11:133743022 C/A cg15485101 chr11:133734466 NA 0.43 8.11 0.41 9.96e-15 Childhood ear infection; CRC cis rs6921919 0.583 rs6899603 chr6:28381305 A/G cg21251018 chr6:28226885 NKAPL 0.39 5.93 0.31 7.61e-9 Autism spectrum disorder or schizophrenia; CRC cis rs58649573 0.530 rs7049026 chr9:126786918 A/C cg14112217 chr9:126806003 NA 0.4 5.76 0.3 1.97e-8 Post-traumatic stress disorder; CRC cis rs10191773 0.535 rs56187472 chr2:113111668 G/A cg24977338 chr2:113188963 RGPD8;RGPD5 -0.61 -5.69 -0.3 2.78e-8 Yeast infection; CRC cis rs4728302 0.559 rs12707093 chr7:133200817 C/T cg10665199 chr7:133106180 EXOC4 0.65 9.72 0.47 8.71e-20 Intelligence;Intelligence (multi-trait analysis); CRC trans rs12438356 0.686 rs16952899 chr15:69468885 T/C cg16612806 chr11:124592229 NA -0.42 -6.24 -0.33 1.35e-9 CTACK levels; CRC cis rs2404602 0.669 rs1875884 chr15:76638161 C/T cg23625390 chr15:77176239 SCAPER 0.5 7.16 0.37 5.43e-12 Blood metabolite levels; CRC cis rs7605827 0.930 rs4140713 chr2:15536128 C/T cg19274914 chr2:15703543 NA 0.39 5.88 0.31 9.87e-9 Educational attainment (years of education); CRC trans rs208520 0.706 rs851601 chr6:66893853 G/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.91 -12.33 -0.56 5.79e-29 Exhaled nitric oxide output; CRC trans rs1814175 0.654 rs7482446 chr11:49779020 A/G cg15704280 chr7:45808275 SEPT13 -1.01 -20.63 -0.75 2.81e-61 Height; CRC cis rs1799949 1.000 rs33926631 chr17:41304463 T/C cg19454999 chr17:41278357 BRCA1;NBR2 0.55 8.63 0.43 2.76e-16 Menopause (age at onset); CRC cis rs9916302 0.718 rs10445306 chr17:37591422 A/G cg00129232 chr17:37814104 STARD3 -0.54 -8.09 -0.41 1.15e-14 Glomerular filtration rate (creatinine); CRC trans rs2303319 0.504 rs62188988 chr2:162531068 T/C cg15843009 chr14:69864932 ERH;SLC39A9 -0.66 -5.96 -0.31 6.38e-9 Cognitive function; CRC cis rs10504229 0.724 rs72649117 chr8:58037639 A/G cg02725872 chr8:58115012 NA -0.35 -5.99 -0.31 5.5e-9 Developmental language disorder (linguistic errors); CRC cis rs9916302 0.904 rs10491128 chr17:37551988 G/A cg00129232 chr17:37814104 STARD3 0.55 8.02 0.4 1.92e-14 Glomerular filtration rate (creatinine); CRC trans rs7873102 0.702 rs7028020 chr9:38007747 C/T cg16226300 chr6:133136135 RPS12;SNORD101 -0.42 -6.3 -0.33 9.56e-10 Brain structure; CRC cis rs7618501 0.521 rs2352984 chr3:49948728 T/C cg05623727 chr3:50126028 RBM5 0.58 10.0 0.48 9.56e-21 Intelligence (multi-trait analysis); CRC cis rs6973256 0.605 rs13237435 chr7:133347570 C/T cg10665199 chr7:133106180 EXOC4 -0.47 -7.47 -0.38 7.47e-13 Intelligence (multi-trait analysis); CRC trans rs11661542 0.967 rs11082043 chr18:20222985 C/G cg00692559 chr1:156737950 PRCC -0.41 -5.97 -0.31 5.99e-9 Intracranial aneurysm; CRC trans rs4650994 0.507 rs2811312 chr1:178617603 A/G cg05059571 chr16:84539110 KIAA1609 0.61 8.13 0.41 8.57e-15 HDL cholesterol levels;HDL cholesterol; CRC cis rs2281845 0.826 rs4915484 chr1:201076917 C/G cg01987224 chr1:201084466 NA 0.52 9.88 0.48 2.46e-20 Permanent tooth development; CRC cis rs6088590 1.000 rs6087623 chr20:33317662 C/G cg08999081 chr20:33150536 PIGU 0.5 8.51 0.42 6.17e-16 Coronary artery disease; CRC cis rs12898370 0.651 rs11634056 chr15:77539914 G/A cg10437265 chr15:77819839 NA 0.55 7.31 0.37 2.01e-12 Risky sexual behaviors (alcohol dependence interaction); CRC cis rs4132509 0.744 rs10927068 chr1:243923452 C/T cg21452805 chr1:244014465 NA 0.59 7.5 0.38 5.91e-13 RR interval (heart rate); CRC cis rs172166 0.694 rs203884 chr6:28077374 G/T cg12273811 chr6:28175739 NA 0.61 8.88 0.44 4.33e-17 Cardiac Troponin-T levels; CRC trans rs58688157 0.705 rs36060383 chr11:598723 A/C cg19188899 chr13:112838565 NA -0.41 -6.4 -0.33 5.35e-10 Systemic lupus erythematosus; CRC cis rs4409675 0.576 rs7535816 chr1:28234054 A/G cg23691781 chr1:28212827 C1orf38 0.33 7.66 0.39 2.15e-13 Corneal astigmatism; CRC cis rs4803468 1.000 rs4803469 chr19:41922775 A/C cg09537434 chr19:41945824 ATP5SL -0.97 -18.77 -0.72 5.95e-54 Height; CRC cis rs6582630 0.555 rs7965311 chr12:38513307 G/A cg26384229 chr12:38710491 ALG10B -0.67 -10.08 -0.49 5.46e-21 Drug-induced liver injury (flucloxacillin); CRC cis rs832540 0.898 rs331498 chr5:56249842 C/G cg20203395 chr5:56204925 C5orf35 0.43 6.14 0.32 2.31e-9 Coronary artery disease; CRC cis rs10791097 0.547 rs1050078 chr11:130746146 T/C cg12179176 chr11:130786555 SNX19 0.78 12.81 0.58 9.18e-31 Autism spectrum disorder or schizophrenia;Schizophrenia; CRC cis rs2739330 0.828 rs5760108 chr22:24252668 G/T cg23131131 chr22:24373011 LOC391322 -0.66 -10.15 -0.49 3.15e-21 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs929354 0.742 rs10251112 chr7:156963524 A/G cg05182265 chr7:156933206 UBE3C -0.76 -14.53 -0.63 2.74e-37 Body mass index; CRC cis rs12541635 0.934 rs1353450 chr8:107035120 A/G cg10147462 chr8:107024639 NA -0.46 -7.92 -0.4 3.66e-14 Age of smoking initiation; CRC cis rs7727544 0.716 rs2089855 chr5:131573529 A/G cg18758796 chr5:131593413 PDLIM4 0.34 6.06 0.32 3.65e-9 Blood metabolite levels; CRC cis rs9435341 0.965 rs1730859 chr1:107617707 A/G cg14828511 chr1:107599125 PRMT6 0.52 7.13 0.37 6.56e-12 Facial morphology (factor 21, depth of nasal alae); CRC cis rs2797160 1.000 rs1418948 chr6:126007018 C/T cg05901451 chr6:126070800 HEY2 0.41 6.21 0.32 1.61e-9 Endometrial cancer; CRC cis rs1707322 1.000 rs7553924 chr1:46352624 T/C cg03146154 chr1:46216737 IPP 0.51 7.1 0.36 7.52e-12 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs11122272 0.701 rs2474628 chr1:231526000 C/T cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.54 -8.14 -0.41 7.99e-15 Hemoglobin concentration; CRC cis rs13118159 0.801 rs13147602 chr4:1332175 A/G cg24560729 chr4:1342394 KIAA1530 0.43 7.4 0.38 1.16e-12 Longevity; CRC cis rs9467711 0.651 rs9467623 chr6:25860580 G/A cg12315302 chr6:26189340 HIST1H4D 0.77 6.0 0.31 5.13e-9 Autism spectrum disorder or schizophrenia; CRC cis rs853679 0.517 rs9368552 chr6:28068426 A/G cg02683197 chr6:28174875 NA 0.82 10.05 0.48 6.9e-21 Depression; CRC cis rs875971 0.660 rs10950044 chr7:66042976 A/G cg25985355 chr7:65971099 NA 0.32 5.71 0.3 2.54e-8 Aortic root size; CRC cis rs7705042 0.686 rs10068466 chr5:141524612 C/T cg07392085 chr5:141489673 NDFIP1 -0.41 -5.96 -0.31 6.36e-9 Asthma; CRC cis rs7680126 0.585 rs34768406 chr4:10118350 C/A cg11266682 chr4:10021025 SLC2A9 -0.44 -6.12 -0.32 2.62e-9 Urate levels in lean individuals;Urate levels in overweight individuals;Urate levels in obese individuals; CRC trans rs1346081 0.786 rs1425645 chr4:68028175 C/T cg18523371 chr4:108911521 HADH 0.49 6.1 0.32 2.95e-9 Intelligence (multi-trait analysis); CRC cis rs9361491 0.605 rs1185343 chr6:79436190 G/C cg05283184 chr6:79620031 NA -0.37 -5.69 -0.3 2.84e-8 Intelligence (multi-trait analysis); CRC cis rs1448094 0.556 rs61930626 chr12:86167445 A/G cg19622623 chr12:86230825 RASSF9 -0.37 -5.64 -0.3 3.62e-8 Major depressive disorder; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg20693608 chr4:113152836 AP1AR 0.36 6.11 0.32 2.87e-9 Liver disease severity in Alagille syndrome; CRC cis rs10256972 0.684 rs2363279 chr7:1096143 A/G cg03923535 chr7:1197113 ZFAND2A 0.57 8.19 0.41 5.85e-15 Longevity;Endometriosis; CRC cis rs9905704 0.647 rs7221274 chr17:57008128 A/G cg12560992 chr17:57184187 TRIM37 0.62 9.4 0.46 9.33e-19 Testicular germ cell tumor; CRC cis rs10911390 0.744 rs12034563 chr1:183591769 A/G cg11505048 chr1:183622726 RGL1;APOBEC4 0.76 6.93 0.36 2.16e-11 Systemic lupus erythematosus; CRC cis rs17253792 0.822 rs13379353 chr14:56050478 G/C cg01858014 chr14:56050164 KTN1 -0.89 -7.94 -0.4 3.15e-14 Putamen volume; CRC cis rs8180040 0.932 rs62248599 chr3:47516728 G/A cg10298567 chr3:47292165 KIF9 0.38 6.09 0.32 3.06e-9 Colorectal cancer; CRC trans rs3807766 0.581 rs6954104 chr7:77693258 C/T cg24378470 chr17:9478950 WDR16;STX8 -0.51 -7.07 -0.36 9.57e-12 3-hydroxypropylmercapturic acid levels in smokers; CRC cis rs10751667 0.666 rs7396059 chr11:970490 C/A cg06064525 chr11:970664 AP2A2 -0.31 -6.35 -0.33 7.27e-10 Alzheimer's disease (late onset); CRC cis rs6502050 0.835 rs67682841 chr17:80117745 T/C cg02741985 chr17:80059408 CCDC57 0.43 7.17 0.37 5.1e-12 Life satisfaction; CRC cis rs10504229 0.683 rs7816733 chr8:58129855 G/A cg24829409 chr8:58192753 C8orf71 -0.55 -8.03 -0.4 1.71e-14 Developmental language disorder (linguistic errors); CRC trans rs12478296 0.685 rs35577962 chr2:242993575 A/G cg18288967 chr1:45987694 PRDX1 0.68 7.19 0.37 4.41e-12 Obesity-related traits; CRC cis rs57221529 0.766 rs72706608 chr5:559203 C/T cg14541582 chr5:601475 NA -0.33 -6.6 -0.34 1.61e-10 Lung disease severity in cystic fibrosis; CRC cis rs1552244 0.935 rs41520445 chr3:10153141 A/C cg00166722 chr3:10149974 C3orf24 -0.7 -9.3 -0.46 2.05e-18 Alzheimer's disease; CRC cis rs34375054 0.624 rs4073534 chr12:125671800 C/T cg06287003 chr12:125626642 AACS -0.58 -7.5 -0.38 5.99e-13 Post bronchodilator FEV1/FVC ratio; CRC cis rs7829975 0.742 rs1533058 chr8:8685190 A/G cg08975724 chr8:8085496 FLJ10661 0.39 5.83 0.31 1.36e-8 Mood instability; CRC cis rs1799949 1.000 rs33926631 chr17:41304463 T/C cg25072359 chr17:41440525 NA 0.46 6.96 0.36 1.84e-11 Menopause (age at onset); CRC cis rs6840360 0.615 rs4696095 chr4:152467243 A/G cg09659197 chr4:152720779 NA 0.31 5.64 0.3 3.65e-8 Intelligence (multi-trait analysis); CRC trans rs7267979 0.844 rs6115188 chr20:25432170 G/T cg17903999 chr18:56338584 MALT1 -0.42 -6.72 -0.35 8e-11 Liver enzyme levels (alkaline phosphatase); CRC cis rs919433 0.756 rs7575389 chr2:198198489 A/G cg20885578 chr2:198174922 NA -0.35 -5.75 -0.3 2.08e-8 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC cis rs2072510 0.593 rs2660838 chr12:96416383 T/C cg15438951 chr12:96389694 HAL -0.48 -5.83 -0.31 1.32e-8 Metabolite levels (small molecules and protein measures); CRC cis rs1997103 1.000 rs2140915 chr7:55410699 G/C cg17469321 chr7:55412551 NA 0.72 11.28 0.53 3.48e-25 QRS interval (sulfonylurea treatment interaction); CRC cis rs7909074 0.531 rs879343 chr10:45400707 G/T cg04218760 chr10:45406644 TMEM72 -0.31 -7.41 -0.38 1.05e-12 Mean corpuscular volume; CRC cis rs2836950 0.545 rs2836940 chr21:40588696 T/C cg11890956 chr21:40555474 PSMG1 -0.66 -9.84 -0.48 3.49e-20 Menarche (age at onset); CRC cis rs35264875 0.898 rs55648928 chr11:68861591 G/T cg15234197 chr11:68924956 NA 0.42 5.8 0.3 1.57e-8 Blond vs. brown hair color; CRC cis rs501120 0.810 rs535176 chr10:44747059 C/T cg09554077 chr10:44749378 NA 0.89 13.2 0.59 3.2e-32 Coronary artery disease;Coronary heart disease; CRC cis rs7246657 1.000 rs7246657 chr19:37747108 C/T cg23950597 chr19:37808831 NA 0.47 5.7 0.3 2.67e-8 Coronary artery calcification; CRC cis rs6502050 0.835 rs8078795 chr17:80126320 C/T cg13198984 chr17:80129470 CCDC57 0.47 8.31 0.42 2.54e-15 Life satisfaction; CRC cis rs2898681 0.618 rs116241740 chr4:53733523 A/G cg26260408 chr4:53727979 RASL11B 0.49 5.61 0.3 4.29e-8 Optic nerve measurement (cup area); CRC cis rs10504229 1.000 rs17216711 chr8:58170856 T/C cg22535103 chr8:58192502 C8orf71 -0.82 -12.27 -0.56 9.63e-29 Developmental language disorder (linguistic errors); CRC cis rs4588572 0.643 rs11744479 chr5:77729220 T/G cg11446398 chr5:77624930 NA 0.46 6.1 0.32 3.02e-9 Triglycerides; CRC cis rs9733 0.596 rs72702504 chr1:150635374 G/C cg10589385 chr1:150898437 SETDB1 0.28 5.98 0.31 5.86e-9 Tonsillectomy; CRC cis rs2108622 0.727 rs7253684 chr19:15981126 C/T cg13772218 chr19:15982569 NA 0.48 6.81 0.35 4.52e-11 Circulating phylloquinone levels;Vitamin E levels;Acenocoumarol maintenance dosage;Response to Vitamin E supplementation;Metabolite levels;Warfarin maintenance dose; CRC cis rs4730250 0.581 rs3779500 chr7:106792704 T/C cg02696742 chr7:106810147 HBP1 0.56 6.36 0.33 6.77e-10 Osteoarthritis; CRC cis rs4658101 0.689 rs6604044 chr1:92051670 C/T cg24006770 chr1:92056542 NA 0.46 6.8 0.35 4.96e-11 Optic disc area;Vertical cup-disc ratio; CRC cis rs896854 0.846 rs13254283 chr8:95914103 G/T cg13393036 chr8:95962371 TP53INP1 -0.49 -8.12 -0.41 9.29e-15 Type 2 diabetes; CRC cis rs5758659 0.504 rs133367 chr22:42463366 A/G cg25452165 chr22:42524984 CYP2D6 -0.43 -6.88 -0.35 3.09e-11 Cognitive function; CRC cis rs7945718 0.967 rs4415740 chr11:12783911 C/T cg25843174 chr11:12811716 TEAD1 0.47 9.04 0.45 1.43e-17 Educational attainment (years of education); CRC cis rs6834538 1.000 rs6816676 chr4:113483843 T/C cg10021238 chr4:113569128 MIR367;LARP7 -0.46 -6.54 -0.34 2.32e-10 Free thyroxine concentration; CRC cis rs1451375 0.617 rs12671474 chr7:50591395 C/A cg18232548 chr7:50535776 DDC 0.45 5.86 0.31 1.12e-8 Malaria; CRC cis rs9560113 0.509 rs28608633 chr13:112206880 G/A cg10483660 chr13:112241077 NA 0.57 10.17 0.49 2.73e-21 Menarche (age at onset); CRC cis rs720844 1.000 rs12619201 chr2:149333358 T/C cg09247360 chr2:149335327 NA -0.61 -7.69 -0.39 1.68e-13 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs6570726 0.791 rs7755253 chr6:145858893 C/G cg13319975 chr6:146136371 FBXO30 -0.46 -6.84 -0.35 3.9e-11 Lobe attachment (rater-scored or self-reported); CRC cis rs270601 0.770 rs61352298 chr5:131600589 G/C cg11843238 chr5:131593191 PDLIM4 0.49 9.29 0.46 2.11e-18 Acylcarnitine levels; CRC cis rs2692947 0.683 rs2315416 chr2:96558477 C/T cg23100626 chr2:96804247 ASTL 0.27 7.11 0.36 7.24e-12 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; CRC cis rs875971 0.545 rs2707851 chr7:66089165 C/T cg03233332 chr7:66118400 NA 0.45 6.29 0.33 9.96e-10 Aortic root size; CRC cis rs11190604 0.767 rs12360395 chr10:102194074 A/T cg07080220 chr10:102295463 HIF1AN 0.47 5.88 0.31 1.02e-8 Palmitoleic acid (16:1n-7) levels; CRC cis rs9303542 0.694 rs9906950 chr17:46577167 A/G cg04904318 chr17:46607828 HOXB1 0.46 6.02 0.32 4.57e-9 Ovarian cancer;Epithelial ovarian cancer; CRC cis rs853679 0.517 rs9380057 chr6:28104634 G/T cg06470822 chr6:28175283 NA 1.0 13.33 0.59 1.06e-32 Depression; CRC cis rs9649213 0.593 rs1468341 chr7:97987696 G/A cg08684580 chr7:98029266 BAIAP2L1 -0.32 -5.67 -0.3 3.09e-8 Prostate cancer (SNP x SNP interaction); CRC cis rs11155671 0.530 rs9383577 chr6:150207195 C/T cg13206674 chr6:150067644 NUP43 0.48 6.95 0.36 1.93e-11 Testicular germ cell tumor; CRC cis rs172166 0.637 rs1225595 chr6:28151340 A/T cg15786705 chr6:28176104 NA 0.68 10.18 0.49 2.51e-21 Cardiac Troponin-T levels; CRC cis rs9443645 0.869 rs1567168 chr6:79536455 G/T cg09184832 chr6:79620586 NA -0.48 -8.96 -0.44 2.52e-17 Intelligence (multi-trait analysis); CRC cis rs1862618 0.853 rs252904 chr5:56118733 A/T cg12311346 chr5:56204834 C5orf35 -0.73 -9.77 -0.47 5.67e-20 Initial pursuit acceleration; CRC cis rs2204008 0.540 rs1283306 chr12:38153778 C/A cg26384229 chr12:38710491 ALG10B -0.56 -8.28 -0.42 3.07e-15 Bladder cancer; CRC cis rs2120019 1.000 rs8033837 chr15:75353975 A/C cg11632617 chr15:75315747 PPCDC -0.52 -7.01 -0.36 1.32e-11 Blood trace element (Zn levels); CRC cis rs9894429 0.646 rs7220310 chr17:79606056 C/A cg09655341 chr17:79618100 PDE6G -0.35 -6.05 -0.32 3.92e-9 Eye color traits; CRC cis rs2404602 0.610 rs28823285 chr15:77050395 T/C cg23625390 chr15:77176239 SCAPER -0.87 -14.46 -0.62 5.11e-37 Blood metabolite levels; CRC trans rs1814175 0.817 rs12277258 chr11:49940216 T/C cg03929089 chr4:120376271 NA -0.98 -19.27 -0.73 6.62e-56 Height; CRC cis rs7666738 0.753 rs11932536 chr4:98930105 A/G cg17366294 chr4:99064904 C4orf37 0.43 7.32 0.37 1.95e-12 Colonoscopy-negative controls vs population controls; CRC cis rs7412746 0.588 rs10305664 chr1:150839686 A/C cg17724175 chr1:150552817 MCL1 0.49 7.18 0.37 4.57e-12 Melanoma; CRC cis rs6570726 0.791 rs401561 chr6:145835917 G/T cg23711669 chr6:146136114 FBXO30 0.74 12.97 0.58 2.27e-31 Lobe attachment (rater-scored or self-reported); CRC trans rs1005277 0.579 rs2474588 chr10:38420870 A/G cg17830980 chr10:43048298 ZNF37B -0.58 -9.74 -0.47 7.57e-20 Extrinsic epigenetic age acceleration; CRC cis rs11098499 0.863 rs3775858 chr4:120486028 A/G cg09307838 chr4:120376055 NA 0.67 10.04 0.48 7.41e-21 Corneal astigmatism; CRC cis rs877282 0.891 rs12767062 chr10:797961 C/T cg17470449 chr10:769945 NA 0.67 8.92 0.44 3.39e-17 Uric acid levels; CRC cis rs477692 0.699 rs528549 chr10:131381574 A/G cg05714579 chr10:131428358 MGMT 0.47 6.65 0.34 1.21e-10 Response to temozolomide; CRC cis rs4664293 0.647 rs2162023 chr2:160426230 G/C cg08347373 chr2:160653686 CD302 -0.39 -6.59 -0.34 1.76e-10 Monocyte percentage of white cells; CRC cis rs763014 1.000 rs7205409 chr16:642610 A/G cg03804128 chr16:635623 NA 0.28 6.49 0.34 3.2e-10 Height; CRC trans rs561341 0.883 rs4795661 chr17:30201774 T/A cg27661571 chr11:113659931 NA 0.62 7.23 0.37 3.45e-12 Hip circumference adjusted for BMI; CRC cis rs11105298 0.891 rs10777163 chr12:89830720 T/C cg00757033 chr12:89920650 WDR51B 0.33 5.62 0.3 4.02e-8 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; CRC cis rs7119 0.651 rs12904533 chr15:77845928 G/A cg27398640 chr15:77910606 LINGO1 -0.42 -7.0 -0.36 1.43e-11 Type 2 diabetes; CRC cis rs9393777 0.778 rs77666565 chr6:26851415 G/A cg16898833 chr6:26189333 HIST1H4D 0.85 6.28 0.33 1.06e-9 Intelligence (multi-trait analysis); CRC cis rs875971 0.545 rs67688847 chr7:65626051 G/A cg11764359 chr7:65958608 NA 0.47 5.9 0.31 9.21e-9 Aortic root size; CRC trans rs11039798 0.511 rs717896 chr11:48375335 G/T cg15704280 chr7:45808275 SEPT13 -0.66 -6.97 -0.36 1.79e-11 Axial length; CRC cis rs9911578 1.000 rs9897326 chr17:56902297 A/G cg12560992 chr17:57184187 TRIM37 0.92 16.91 0.68 1.29e-46 Intelligence (multi-trait analysis); CRC cis rs1816752 0.870 rs2033955 chr13:25010544 T/C cg02811702 chr13:24901961 NA 0.47 6.59 0.34 1.7e-10 Obesity-related traits; CRC cis rs7927771 0.894 rs12798346 chr11:47583121 C/T cg05585544 chr11:47624801 NA -0.62 -11.41 -0.53 1.22e-25 Subjective well-being; CRC cis rs1448094 0.817 rs10863108 chr12:86328249 C/T cg02569458 chr12:86230093 RASSF9 0.46 7.68 0.39 1.89e-13 Major depressive disorder; CRC cis rs9916302 0.851 rs612209 chr17:37442713 G/C cg07936489 chr17:37558343 FBXL20 0.81 12.55 0.57 8.49e-30 Glomerular filtration rate (creatinine); CRC cis rs875971 1.000 rs11974219 chr7:65647410 C/T cg11764359 chr7:65958608 NA -0.61 -9.95 -0.48 1.45e-20 Aortic root size; CRC cis rs1552244 1.000 rs17032276 chr3:10076975 A/C cg00166722 chr3:10149974 C3orf24 0.71 9.49 0.46 4.86e-19 Alzheimer's disease; CRC cis rs7216064 0.911 rs12449442 chr17:65947640 G/A cg12091567 chr17:66097778 LOC651250 -0.61 -7.22 -0.37 3.71e-12 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CRC trans rs208520 0.690 rs864314 chr6:66814830 G/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.19 -26.05 -0.82 5.89e-82 Exhaled nitric oxide output; CRC cis rs7811142 0.775 rs6946768 chr7:99954393 G/A cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.71 9.16 0.45 5.66e-18 Platelet count; CRC cis rs939574 0.722 rs55951006 chr2:220132151 C/T cg00496455 chr2:220118770 TUBA4A;TUBA4B 0.86 7.88 0.4 4.93e-14 Platelet distribution width; CRC cis rs4821897 0.514 rs739141 chr22:39824450 A/G cg25956985 chr22:39795188 MAP3K7IP1 0.45 6.71 0.35 8.53e-11 IgG glycosylation; CRC cis rs4731207 0.596 rs7794538 chr7:124648850 C/T cg23710748 chr7:124431027 NA -0.39 -6.17 -0.32 1.99e-9 Cutaneous malignant melanoma; CRC cis rs17023223 0.537 rs11487668 chr1:119726796 T/C cg05756136 chr1:119680316 WARS2 -0.52 -7.14 -0.37 6e-12 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for BMI in active individuals; CRC cis rs6921919 0.583 rs2071965 chr6:28403225 C/T cg21251018 chr6:28226885 NKAPL 0.39 6.1 0.32 2.91e-9 Autism spectrum disorder or schizophrenia; CRC trans rs11039798 0.588 rs61932767 chr11:48704806 C/T cg03929089 chr4:120376271 NA 0.61 6.56 0.34 2.03e-10 Axial length; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg20959894 chr7:27779871 TAX1BP1 -0.39 -6.03 -0.32 4.49e-9 Myopia (pathological); CRC cis rs875971 0.862 rs1643375 chr7:65872677 T/C cg18876405 chr7:65276391 NA 0.51 8.56 0.43 4.3e-16 Aortic root size; CRC cis rs939317 0.678 rs843372 chr3:183996213 C/T cg09405238 chr3:183994500 ECE2 0.52 6.15 0.32 2.23e-9 Menarche (age at onset); CRC cis rs3736485 0.966 rs7170444 chr15:51890500 G/A cg08986416 chr15:51914746 DMXL2 -0.45 -6.42 -0.33 4.76e-10 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs9891119 0.576 rs6503696 chr17:40499804 C/T cg06270615 chr17:40516068 STAT3 -0.35 -7.56 -0.38 3.99e-13 Multiple sclerosis;Crohn's disease; CRC cis rs6964587 1.000 rs13230588 chr7:91615427 C/A cg17063962 chr7:91808500 NA 0.8 14.25 0.62 3.13e-36 Breast cancer; CRC cis rs28386778 0.562 rs721575 chr17:61782920 A/G cg25654072 chr17:61904446 PSMC5;FTSJ3 -0.62 -9.5 -0.46 4.4e-19 Prudent dietary pattern; CRC cis rs4713118 0.513 rs149950 chr6:28033039 T/G cg25164649 chr6:28176230 NA 0.6 8.62 0.43 2.96e-16 Parkinson's disease; CRC trans rs2303319 0.504 rs62187656 chr2:162487699 A/G cg10272801 chr16:14013773 ERCC4 -0.69 -6.02 -0.31 4.59e-9 Cognitive function; CRC cis rs12762955 0.677 rs11250267 chr10:1156487 A/G cg26597838 chr10:835615 NA 0.58 7.29 0.37 2.37e-12 Response to angiotensin II receptor blocker therapy; CRC cis rs801193 1.000 rs3857688 chr7:66127806 G/A cg11764359 chr7:65958608 NA -0.54 -8.3 -0.42 2.71e-15 Aortic root size; CRC cis rs11190604 1.000 rs1054399 chr10:102312565 C/T cg07080220 chr10:102295463 HIF1AN 0.5 6.19 0.32 1.78e-9 Palmitoleic acid (16:1n-7) levels; CRC cis rs6502050 0.835 rs7405738 chr17:80084227 A/G cg13198984 chr17:80129470 CCDC57 -0.48 -8.56 -0.43 4.49e-16 Life satisfaction; CRC cis rs7385804 0.761 rs1617640 chr7:100317298 C/A cg20848291 chr7:100343083 ZAN 0.49 7.47 0.38 7.49e-13 Iron status biomarkers;Mean corpuscular hemoglobin;Hematocrit;Iron status biomarkers (transferrin saturation);Red blood cell count;Iron status biomarkers (iron levels);Mean corpuscular volume;Hematological parameters; CRC cis rs4631830 0.720 rs4935573 chr10:51504385 A/G cg20129853 chr10:51489980 NA 0.35 5.78 0.3 1.7e-8 Prostate-specific antigen levels; CRC cis rs2204008 0.720 rs11180923 chr12:38255172 A/T cg13010199 chr12:38710504 ALG10B 0.44 5.73 0.3 2.33e-8 Bladder cancer; CRC cis rs9372498 0.505 rs9489462 chr6:118927855 C/T cg07617317 chr6:118971624 C6orf204 0.49 6.0 0.31 5.29e-9 Diastolic blood pressure; CRC cis rs2739330 0.828 rs2330635 chr22:24251344 T/C cg10150615 chr22:24372951 LOC391322 -0.62 -9.25 -0.45 2.96e-18 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs7072216 0.763 rs7910247 chr10:100172252 C/T cg26618903 chr10:100175079 PYROXD2 -0.55 -8.99 -0.44 2.03e-17 Metabolite levels; CRC trans rs951252 0.504 rs11734405 chr4:146081096 C/T cg08125682 chr16:11038455 CLEC16A 0.44 5.97 0.31 6.28e-9 Hip circumference; CRC cis rs10463316 0.832 rs246482 chr5:150731857 C/G cg03212797 chr5:150827313 SLC36A1 -0.51 -7.65 -0.39 2.29e-13 Metabolite levels (Pyroglutamine); CRC cis rs1887596 0.607 rs9553870 chr13:27170716 G/A cg01312412 chr13:27282625 NA 0.43 5.7 0.3 2.72e-8 Facial morphology (factor 3, length of philtrum); CRC cis rs1552244 1.000 rs13319597 chr3:10126312 A/C cg10729496 chr3:10149963 C3orf24 -0.53 -7.14 -0.37 6.18e-12 Alzheimer's disease; CRC cis rs2274273 0.624 rs10143136 chr14:55743528 G/A cg10130446 chr14:55658398 DLGAP5 -0.41 -5.82 -0.31 1.43e-8 Protein biomarker; CRC cis rs4713118 0.513 rs202908 chr6:28011551 C/G cg21251018 chr6:28226885 NKAPL 0.47 7.37 0.38 1.43e-12 Parkinson's disease; CRC cis rs231513 0.911 rs124722 chr17:41956002 T/G cg26893861 chr17:41843967 DUSP3 -0.67 -6.76 -0.35 6.29e-11 Cognitive function; CRC cis rs1348850 0.668 rs13010396 chr2:178492934 T/C cg22681709 chr2:178499509 PDE11A -0.37 -6.09 -0.32 3.17e-9 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs9291683 0.632 rs13137074 chr4:10042842 C/T cg00071950 chr4:10020882 SLC2A9 0.67 12.67 0.57 3.14e-30 Bone mineral density; CRC cis rs17711722 0.522 rs4642526 chr7:65216742 G/T cg24585817 chr7:64895279 NA 0.36 5.67 0.3 3.11e-8 Calcium levels; CRC trans rs11039798 0.588 rs7108164 chr11:48626363 A/C cg03929089 chr4:120376271 NA 0.67 7.17 0.37 5.14e-12 Axial length; CRC cis rs7705042 0.865 rs4391200 chr5:141509537 A/G cg07392085 chr5:141489673 NDFIP1 0.46 7.24 0.37 3.17e-12 Asthma; CRC cis rs6502050 0.871 rs8066137 chr17:80074316 T/C cg22110888 chr17:80059540 CCDC57 -0.42 -6.62 -0.34 1.48e-10 Life satisfaction; CRC cis rs9463078 0.774 rs9357484 chr6:45265882 C/A cg25276700 chr6:44698697 NA -0.28 -6.72 -0.35 8.12e-11 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; CRC cis rs2576037 0.899 rs2576035 chr18:44587654 C/T cg19077165 chr18:44547161 KATNAL2 0.47 7.23 0.37 3.35e-12 Personality dimensions; CRC cis rs225245 0.791 rs8067294 chr17:34027964 T/C cg05299278 chr17:33885742 SLFN14 0.5 8.12 0.41 9.57e-15 Reticulocyte count;Reticulocyte fraction of red cells;High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells; CRC cis rs4481887 0.861 rs7412034 chr1:248434150 G/C cg13385794 chr1:248469461 NA 0.4 7.29 0.37 2.35e-12 Common traits (Other); CRC cis rs4713118 0.621 rs10484403 chr6:28033523 A/G cg21251018 chr6:28226885 NKAPL 0.47 6.36 0.33 6.92e-10 Parkinson's disease; CRC cis rs12188164 0.930 rs72717436 chr5:448291 C/A cg17553881 chr5:443987 EXOC3;C5orf55 -0.37 -7.81 -0.4 7.64e-14 Cystic fibrosis severity; CRC trans rs3942852 0.568 rs1039484 chr11:48097948 A/G cg15704280 chr7:45808275 SEPT13 -0.68 -9.57 -0.47 2.73e-19 Acute lymphoblastic leukemia (childhood); CRC trans rs34421088 0.560 rs2245357 chr8:11399484 A/T cg06636001 chr8:8085503 FLJ10661 -0.54 -7.92 -0.4 3.66e-14 Neuroticism; CRC cis rs7927771 0.832 rs11601603 chr11:47401171 A/C cg20307385 chr11:47447363 PSMC3 -0.62 -9.24 -0.45 3.24e-18 Subjective well-being; CRC cis rs920590 0.758 rs7012358 chr8:19662498 C/T cg03894339 chr8:19674705 INTS10 0.42 5.73 0.3 2.27e-8 Acute lymphoblastic leukemia (childhood); CRC cis rs7193541 0.585 rs3851729 chr16:74485529 A/G cg01733217 chr16:74700730 RFWD3 -0.87 -16.76 -0.68 5.07e-46 Multiple myeloma; CRC cis rs1322639 1.000 rs9689079 chr6:169587148 A/G cg04662567 chr6:169592167 NA 0.46 7.66 0.39 2.07e-13 Pulse pressure; CRC cis rs6860806 0.507 rs273915 chr5:131660119 G/C cg22638593 chr5:131593259 PDLIM4 0.38 6.29 0.33 1e-9 Breast cancer; CRC cis rs6681460 0.625 rs12127199 chr1:67103742 T/C cg02459107 chr1:67143332 SGIP1 0.32 5.71 0.3 2.49e-8 Presence of antiphospholipid antibodies; CRC cis rs453301 0.658 rs6986044 chr8:8874786 G/C cg08975724 chr8:8085496 FLJ10661 -0.38 -5.69 -0.3 2.85e-8 Joint mobility (Beighton score); CRC cis rs7909074 1.000 rs4948927 chr10:45397071 G/A cg04218760 chr10:45406644 TMEM72 -0.35 -9.76 -0.47 6.33e-20 Mean corpuscular volume; CRC cis rs9522267 0.535 rs914036 chr13:112235542 G/A cg10483660 chr13:112241077 NA -0.48 -9.0 -0.44 1.85e-17 Hepatitis; CRC cis rs9420 0.961 rs682503 chr11:57640994 C/G cg23127183 chr11:57508653 C11orf31 0.47 6.43 0.33 4.51e-10 Schizophrenia; CRC cis rs7945705 0.837 rs10769981 chr11:9024460 T/C cg14711859 chr11:8959438 ASCL3 -0.47 -7.4 -0.38 1.17e-12 Hemoglobin concentration; CRC cis rs796364 1.000 rs796364 chr2:200716119 C/A cg12253985 chr2:200820533 C2orf60;C2orf47 0.6 6.75 0.35 6.77e-11 Schizophrenia; CRC cis rs875971 0.895 rs778700 chr7:65866450 C/T cg18876405 chr7:65276391 NA 0.52 9.04 0.45 1.37e-17 Aortic root size; CRC cis rs6500395 1.000 rs2354579 chr16:48601521 T/C cg04672837 chr16:48644449 N4BP1 0.44 6.5 0.34 2.95e-10 Response to tocilizumab in rheumatoid arthritis; CRC cis rs8072100 0.688 rs7221224 chr17:45419061 T/G cg08085267 chr17:45401833 C17orf57 0.56 8.33 0.42 2.29e-15 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs1218582 0.772 rs4845690 chr1:154886817 C/T cg06221963 chr1:154839813 KCNN3 0.76 15.74 0.66 5.35e-42 Prostate cancer; CRC cis rs17666538 0.539 rs1703925 chr8:608279 A/G cg02524346 chr8:600233 NA 0.92 8.51 0.42 6.18e-16 IgG glycosylation; CRC cis rs6964587 1.000 rs2097739 chr7:91711466 C/T cg17063962 chr7:91808500 NA 0.79 14.1 0.61 1.24e-35 Breast cancer; CRC cis rs35883536 1.000 rs1832123 chr1:101168196 A/G cg14515779 chr1:101123966 NA -0.44 -8.39 -0.42 1.46e-15 Monocyte count; CRC cis rs1062746 0.520 rs17770996 chr16:87330207 G/A cg02258303 chr16:87377426 FBXO31 -0.51 -7.42 -0.38 9.82e-13 Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 2 peripheral neuropathy); CRC trans rs7580658 0.614 rs7585198 chr2:127962635 C/T cg22956015 chr17:38279503 MSL1 -0.47 -6.52 -0.34 2.64e-10 Protein C levels; CRC cis rs989128 0.600 rs916978 chr17:48630452 T/C cg16068336 chr17:48637367 CACNA1G -0.5 -7.3 -0.37 2.22e-12 Type 2 diabetes; CRC cis rs9818758 0.607 rs9990153 chr3:49291883 C/T cg07636037 chr3:49044803 WDR6 -0.7 -5.96 -0.31 6.48e-9 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; CRC cis rs7487075 0.619 rs9971879 chr12:46806773 T/C cg22049899 chr12:47219821 SLC38A4 0.31 5.67 0.3 3.17e-8 Itch intensity from mosquito bite; CRC cis rs1364705 1.000 rs61600037 chr8:120225613 T/C cg27215916 chr8:120218354 NA -0.39 -5.64 -0.3 3.73e-8 Hippocampal atrophy; CRC cis rs6867032 0.527 rs4975777 chr5:1973324 G/T cg26168224 chr5:2018326 NA -0.77 -10.7 -0.51 4.08e-23 Gut microbiome composition (winter); CRC cis rs57221529 0.709 rs72706612 chr5:561198 C/T cg17948913 chr5:572064 NA 0.55 6.25 0.33 1.29e-9 Lung disease severity in cystic fibrosis; CRC cis rs4453791 0.652 rs55991947 chr3:39077763 G/A cg02254461 chr3:39195904 CSRNP1 0.45 5.76 0.3 1.97e-8 Social communication problems; CRC cis rs2836974 0.899 rs35774464 chr21:40580169 G/A cg17971929 chr21:40555470 PSMG1 0.73 9.99 0.48 1.09e-20 Cognitive function; CRC cis rs1267303 0.675 rs1267313 chr1:46986322 G/T cg25110126 chr1:46999211 NA -0.55 -8.31 -0.42 2.52e-15 Monobrow; CRC cis rs12701220 0.901 rs12701708 chr7:1090333 C/T cg02733842 chr7:1102375 C7orf50 -0.77 -9.64 -0.47 1.5700000000000001e-19 Bronchopulmonary dysplasia; CRC cis rs4332037 0.707 rs62435130 chr7:1890002 C/T cg23422044 chr7:1970798 MAD1L1 -0.49 -6.36 -0.33 6.81e-10 Bipolar disorder; CRC cis rs3617 0.573 rs4687682 chr3:52916939 T/C cg15147215 chr3:52552868 STAB1 0.46 7.86 0.4 5.47e-14 Red blood cell count;Autism spectrum disorder or schizophrenia; CRC trans rs3808502 0.585 rs4549730 chr8:11239078 T/G cg06636001 chr8:8085503 FLJ10661 -0.44 -6.54 -0.34 2.31e-10 Neuroticism; CRC cis rs4243830 0.850 rs932112 chr1:6591937 A/G cg05709478 chr1:6581295 PLEKHG5 -0.6 -7.15 -0.37 5.78e-12 Body mass index; CRC cis rs4819052 0.851 rs7275468 chr21:46656499 C/A cg19498844 chr21:46707878 POFUT2;LOC642852 0.64 9.08 0.45 1.04e-17 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs240768 0.511 rs61289570 chr6:101403098 C/T cg12253828 chr6:101329408 ASCC3 0.8 6.53 0.34 2.47e-10 Economic and political preferences (immigration/crime); CRC cis rs10504229 1.000 rs7007805 chr8:58179327 G/A cg22535103 chr8:58192502 C8orf71 -0.82 -12.27 -0.56 9.63e-29 Developmental language disorder (linguistic errors); CRC cis rs7726839 0.526 rs55647623 chr5:567747 T/C cg09021430 chr5:549028 NA -0.82 -10.79 -0.51 1.94e-23 Obesity-related traits; CRC cis rs7542091 0.704 rs4133950 chr1:210044393 C/G cg05527609 chr1:210001259 C1orf107 -0.44 -5.86 -0.31 1.15e-8 Monobrow; CRC cis rs208520 0.690 rs207096 chr6:66797287 T/C cg07460842 chr6:66804631 NA -1.08 -15.25 -0.64 4.51e-40 Exhaled nitric oxide output; CRC cis rs12630931 0.862 rs13099690 chr3:31982261 G/T cg21375017 chr3:31988082 OSBPL10 0.42 5.76 0.3 1.94e-8 Periodontal disease-related phenotypes; CRC cis rs28386778 0.769 rs6504179 chr17:61812995 T/G cg11494091 chr17:61959527 GH2 0.51 8.23 0.41 4.35e-15 Prudent dietary pattern; CRC cis rs6964587 1.000 rs28584017 chr7:91719168 G/A cg17063962 chr7:91808500 NA 0.8 14.37 0.62 1.08e-36 Breast cancer; CRC cis rs2249296 0.715 rs2791465 chr1:86908698 C/T cg17424433 chr1:86913263 CLCA2 -0.41 -5.72 -0.3 2.46e-8 Crohn's disease-related phenotypes; CRC cis rs897984 0.609 rs17839567 chr16:31057945 A/G cg00531865 chr16:30841666 NA -0.44 -6.3 -0.33 9.71e-10 Dementia with Lewy bodies; CRC cis rs10504229 0.906 rs66480865 chr8:58187100 C/T cg24829409 chr8:58192753 C8orf71 -0.68 -11.34 -0.53 2.27e-25 Developmental language disorder (linguistic errors); CRC cis rs9868809 0.881 rs9878063 chr3:48678971 T/G cg07636037 chr3:49044803 WDR6 -0.67 -6.89 -0.36 2.89e-11 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; CRC trans rs1572511 0.710 rs12121835 chr1:177628511 A/G cg10064897 chr1:46598380 PIK3R3 0.43 6.45 0.34 4.02e-10 Amyotrophic lateral sclerosis (sporadic); CRC cis rs7666738 0.830 rs2114425 chr4:99023967 T/C cg05340658 chr4:99064831 C4orf37 0.61 9.35 0.46 1.39e-18 Colonoscopy-negative controls vs population controls; CRC cis rs7412746 0.524 rs58304714 chr1:150831561 T/A cg18016565 chr1:150552671 MCL1 0.44 6.04 0.32 4.07e-9 Melanoma; CRC cis rs6502050 0.734 rs9674631 chr17:80096525 A/G cg13198984 chr17:80129470 CCDC57 0.47 8.46 0.42 9.01e-16 Life satisfaction; CRC cis rs7809950 0.817 rs2807 chr7:107260778 G/A cg23024343 chr7:107201750 COG5 0.74 10.2 0.49 2.03e-21 Coronary artery disease; CRC trans rs9858542 1.000 rs6770670 chr3:49686682 T/C cg21665057 chr3:196295764 WDR53;FBXO45 -0.68 -8.9 -0.44 3.71e-17 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs11212617 0.967 rs4237579 chr11:108279201 A/G cg01991180 chr11:108092276 ATM;NPAT 0.43 6.39 0.33 5.72e-10 Response to metformin in type 2 diabetes (glycemic); CRC cis rs12541635 0.677 rs34872724 chr8:107033071 C/T cg10147462 chr8:107024639 NA -0.59 -10.74 -0.51 2.88e-23 Age of smoking initiation; CRC trans rs800082 0.690 rs6440260 chr3:144289214 C/A cg24215973 chr2:240111563 HDAC4 -0.65 -10.25 -0.49 1.46e-21 Smoking behavior; CRC cis rs60012524 1 rs60012524 chr2:99559117 T/C cg14399236 chr2:99771627 LIPT1;TSGA10 -0.7 -8.52 -0.43 5.77e-16 Chronic sinus infection; CRC cis rs9611519 0.579 rs8136274 chr22:41415311 T/C cg03806693 chr22:41940476 POLR3H -0.4 -5.73 -0.3 2.26e-8 Neuroticism; CRC cis rs11785400 1.000 rs13266249 chr8:143732433 A/C cg10596483 chr8:143751796 JRK 0.52 7.34 0.38 1.65e-12 Schizophrenia; CRC cis rs4663866 0.901 rs76312449 chr2:239190906 A/G cg16914508 chr2:239161102 PER2 0.74 7.99 0.4 2.26e-14 Irritable bowel syndrome; CRC cis rs877282 0.898 rs11253348 chr10:765852 C/T cg17470449 chr10:769945 NA 0.64 8.08 0.41 1.28e-14 Uric acid levels; CRC cis rs875971 0.522 rs9530 chr7:65425894 A/G cg18876405 chr7:65276391 NA 0.67 12.08 0.55 4.85e-28 Aortic root size; CRC cis rs798554 1.000 rs798544 chr7:2763102 A/G cg14895029 chr7:2775587 GNA12 0.4 6.03 0.32 4.38e-9 Height; CRC cis rs7586879 0.575 rs6706316 chr2:25128351 C/G cg22495460 chr2:25135724 ADCY3 -0.87 -17.55 -0.7 3.84e-49 Body mass index; CRC cis rs6724607 1.000 rs7598979 chr2:191453375 A/G cg10560079 chr2:191398806 TMEM194B 0.46 6.5 0.34 2.91e-10 Pulse pressure; CRC cis rs992157 0.710 rs12612347 chr2:219057338 C/T cg04731861 chr2:219085781 ARPC2 0.3 6.23 0.32 1.44e-9 Colorectal cancer; CRC cis rs1005277 0.505 rs719569 chr10:38154415 T/G cg25427524 chr10:38739819 LOC399744 0.75 13.13 0.59 5.82e-32 Extrinsic epigenetic age acceleration; CRC cis rs17767392 0.958 rs2108049 chr14:71962394 G/T cg13720639 chr14:72061746 SIPA1L1 -0.57 -7.19 -0.37 4.29e-12 Mitral valve prolapse; CRC cis rs12410462 0.681 rs78978081 chr1:227571619 G/A cg23173402 chr1:227635558 NA 0.73 6.79 0.35 5.22e-11 Major depressive disorder; CRC cis rs12950390 0.814 rs11659069 chr17:45834275 G/T cg24803719 chr17:45855879 NA -0.3 -6.57 -0.34 2.01e-10 IgG glycosylation; CRC cis rs2303745 0.622 rs1864113 chr19:17393504 G/C cg04248312 chr19:17393744 ANKLE1 -0.93 -14.35 -0.62 1.31e-36 Systemic lupus erythematosus; CRC cis rs10870270 0.956 rs11146325 chr10:133767529 A/G cg08754478 chr10:133766260 PPP2R2D -0.66 -9.22 -0.45 3.72e-18 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; CRC cis rs11122272 0.735 rs2808580 chr1:231509259 A/G cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.54 -8.11 -0.41 1.04e-14 Hemoglobin concentration; CRC cis rs2249694 0.919 rs2987794 chr10:135378612 G/T cg20169779 chr10:135381914 SYCE1 0.55 8.87 0.44 4.66e-17 Obesity-related traits; CRC cis rs9486719 0.895 rs12190520 chr6:96928620 A/C cg06623918 chr6:96969491 KIAA0776 -0.79 -9.15 -0.45 6.31e-18 Migraine;Coronary artery disease; CRC cis rs7586879 0.638 rs10203482 chr2:25136916 T/C cg04586622 chr2:25135609 ADCY3 -0.56 -10.18 -0.49 2.42e-21 Body mass index; CRC cis rs4862750 0.872 rs11947595 chr4:187899827 C/T cg06074448 chr4:187884817 NA -0.6 -11.3 -0.53 2.95e-25 Lobe attachment (rater-scored or self-reported); CRC cis rs7666738 0.830 rs11942114 chr4:99066261 C/G cg05340658 chr4:99064831 C4orf37 0.58 8.85 0.44 5.47e-17 Colonoscopy-negative controls vs population controls; CRC cis rs875971 0.522 rs6960048 chr7:65408039 A/G cg02869306 chr7:64672164 INTS4L1 -0.35 -5.9 -0.31 8.87e-9 Aortic root size; CRC cis rs12048904 0.595 rs2295280 chr1:101342497 T/C cg16556008 chr1:101360663 SLC30A7;EXTL2 0.8 12.74 0.57 1.64e-30 Multiple sclerosis; CRC cis rs7772486 0.712 rs1292335 chr6:145967877 G/T cg23711669 chr6:146136114 FBXO30 0.66 10.82 0.51 1.46e-23 Lobe attachment (rater-scored or self-reported); CRC cis rs1572438 1.000 rs9328455 chr6:864095 C/T cg13447295 chr6:887704 NA -0.45 -6.26 -0.33 1.19e-9 Aging; CRC trans rs10982213 0.830 rs2274163 chr9:117188714 C/T cg18879991 chr6:27861393 HIST1H2AM;HIST1H2BO 0.42 6.23 0.32 1.42e-9 Interleukin-6 levels; CRC cis rs6543140 0.964 rs4851010 chr2:103056127 A/T cg03938978 chr2:103052716 IL18RAP -0.45 -6.96 -0.36 1.9e-11 Blood protein levels; CRC cis rs977987 0.806 rs34021527 chr16:75474090 A/G cg03315344 chr16:75512273 CHST6 0.55 9.45 0.46 6.4e-19 Dupuytren's disease; CRC cis rs10791323 0.569 rs10750542 chr11:133713436 T/C cg15485101 chr11:133734466 NA 0.44 7.55 0.38 4.35e-13 Childhood ear infection; CRC cis rs7618915 0.547 rs34173654 chr3:52634605 T/C cg07507251 chr3:52567010 NT5DC2 0.45 6.51 0.34 2.8e-10 Bipolar disorder; CRC cis rs2617583 0.509 rs62331137 chr5:1459573 A/G cg07148919 chr5:1466943 LPCAT1 -0.45 -5.87 -0.31 1.08e-8 Breast cancer; CRC trans rs951252 0.504 rs11734405 chr4:146081096 C/T cg01626434 chr5:42993978 NA -0.45 -6.39 -0.33 5.62e-10 Hip circumference; CRC cis rs7786808 0.504 rs10949725 chr7:158196003 C/T cg15440763 chr7:158190612 PTPRN2 -0.41 -6.73 -0.35 7.62e-11 Obesity-related traits; CRC cis rs35306767 0.903 rs13377166 chr10:886259 G/A cg20503657 chr10:835505 NA 0.93 11.28 0.53 3.59e-25 Eosinophil percentage of granulocytes; CRC trans rs9858542 0.953 rs9818590 chr3:49525096 A/G cg21582582 chr3:182698605 DCUN1D1 -0.51 -6.43 -0.33 4.42e-10 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs9640161 0.659 rs7788316 chr7:150013995 A/T cg12556325 chr7:150026731 C7orf29;LRRC61 -0.39 -6.13 -0.32 2.5e-9 Blood protein levels;Circulating chemerin levels; CRC cis rs1799949 0.965 rs8176161 chr17:41241390 C/A cg25072359 chr17:41440525 NA 0.47 7.02 0.36 1.27e-11 Menopause (age at onset); CRC cis rs921968 0.643 rs2556384 chr2:219532903 C/T cg02176678 chr2:219576539 TTLL4 -0.47 -7.58 -0.39 3.61e-13 Mean corpuscular hemoglobin concentration; CRC trans rs9929218 1.000 rs2113200 chr16:68814948 A/T cg04657470 chr2:198365150 HSPE1;HSPD1 -0.8 -11.46 -0.53 7.94e-26 Colorectal cancer; CRC cis rs1023500 0.505 rs134889 chr22:42674350 A/T cg15557168 chr22:42548783 NA -0.37 -6.38 -0.33 5.88e-10 Schizophrenia; CRC cis rs6696846 0.740 rs12125465 chr1:205074854 C/A cg00857998 chr1:205179979 DSTYK 0.45 6.3 0.33 9.48e-10 Red blood cell count; CRC cis rs741668 0.931 rs61953331 chr13:46589471 C/T cg06018095 chr13:46550134 ZC3H13 0.41 5.73 0.3 2.21e-8 Cerebrospinal fluid clusterin levels; CRC cis rs2153535 0.580 rs6902001 chr6:8477055 T/G cg21535247 chr6:8435926 SLC35B3 0.5 7.53 0.38 4.89e-13 Motion sickness; CRC cis rs28386778 0.897 rs1062791 chr17:61896487 C/T cg06601766 chr17:61851465 DDX42;CCDC47 0.43 5.91 0.31 8.38e-9 Prudent dietary pattern; CRC cis rs9462846 0.959 rs6937172 chr6:42884375 A/T cg10862848 chr6:42927986 GNMT -0.31 -5.87 -0.31 1.07e-8 Blood protein levels; CRC cis rs11098499 0.863 rs12498539 chr4:120468370 C/T cg09307838 chr4:120376055 NA 0.67 10.27 0.49 1.24e-21 Corneal astigmatism; CRC cis rs2243480 1.000 rs7787230 chr7:65629099 G/A cg12463550 chr7:65579703 CRCP -0.71 -6.52 -0.34 2.65e-10 Diabetic kidney disease; CRC cis rs6088590 0.930 rs6087618 chr20:33288407 C/T cg24642439 chr20:33292090 TP53INP2 0.61 10.9 0.52 7.77e-24 Coronary artery disease; CRC cis rs7493 0.950 rs17879277 chr7:95030632 A/C cg20119798 chr7:94954144 PON1 -0.5 -6.25 -0.33 1.26e-9 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs926392 0.572 rs6129158 chr20:37673967 A/G cg16355469 chr20:37678765 NA 0.49 7.59 0.39 3.42e-13 Dialysis-related mortality; CRC cis rs7310409 0.544 rs1169292 chr12:121426478 C/T cg02403541 chr12:121454288 C12orf43 0.42 6.17 0.32 1.99e-9 Liver enzyme levels (gamma-glutamyl transferase);C-reactive protein;Pancreatic cancer; CRC cis rs9372498 0.536 rs72954806 chr6:118899965 C/G cg18833306 chr6:118973337 C6orf204 0.44 5.76 0.3 1.9e-8 Diastolic blood pressure; CRC cis rs875971 1.000 rs778696 chr7:65870813 C/G cg18912574 chr7:65842487 NCRNA00174 0.36 6.18 0.32 1.88e-9 Aortic root size; CRC cis rs7727544 0.901 rs55633655 chr5:131598756 T/G cg02033258 chr5:131593261 PDLIM4 0.34 6.79 0.35 5.18e-11 Blood metabolite levels; CRC cis rs60871478 0.898 rs62432897 chr7:825429 A/G cg13798912 chr7:905769 UNC84A 0.52 6.06 0.32 3.71e-9 Cerebrospinal P-tau181p levels; CRC cis rs2463822 0.925 rs6863 chr11:62160725 G/T cg06239285 chr11:62104954 ASRGL1 -0.89 -9.39 -0.46 1.05e-18 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs1185460 0.967 rs1784302 chr11:118940957 C/G cg23280166 chr11:118938394 VPS11 0.44 6.67 0.35 1.07e-10 Coronary artery disease; CRC trans rs2303319 0.504 rs12467625 chr2:162603387 C/A cg04551154 chr10:95462393 C10orf4 -0.75 -6.37 -0.33 6.43e-10 Cognitive function; CRC cis rs910316 0.967 rs4384542 chr14:75658013 A/C cg11812906 chr14:75593930 NEK9 -0.52 -7.86 -0.4 5.51e-14 Height; CRC cis rs10911251 0.546 rs7473 chr1:183114634 G/A ch.1.3577855R chr1:183094577 LAMC1 0.82 14.58 0.63 1.7e-37 Colorectal cancer; CRC cis rs3764563 1.000 rs2283603 chr19:15731128 T/C cg20725493 chr19:15740067 CYP4F8 -0.73 -7.29 -0.37 2.37e-12 Inflammatory biomarkers; CRC trans rs561341 0.556 rs542244 chr17:30307242 T/C cg20587970 chr11:113659929 NA -1.43 -20.51 -0.75 8.67e-61 Hip circumference adjusted for BMI; CRC cis rs4819052 0.851 rs7276828 chr21:46695039 T/G cg11663144 chr21:46675770 NA -0.85 -14.5 -0.62 3.46e-37 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs875971 0.545 rs1638735 chr7:66095738 C/T cg18876405 chr7:65276391 NA 0.45 6.15 0.32 2.24e-9 Aortic root size; CRC cis rs11098499 0.866 rs11098506 chr4:120284971 A/G cg09307838 chr4:120376055 NA 0.67 10.35 0.5 6.55e-22 Corneal astigmatism; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg02461806 chr17:4046409 ZZEF1;CYB5D2 0.43 6.33 0.33 7.84e-10 Intelligence (multi-trait analysis); CRC trans rs637571 0.522 rs566590 chr11:65754062 C/T cg17712092 chr4:129076599 LARP1B 0.66 10.77 0.51 2.27e-23 Eosinophil percentage of white cells; CRC cis rs6921919 0.638 rs2108926 chr6:28308747 A/T cg06470822 chr6:28175283 NA 0.48 6.38 0.33 6.04e-10 Autism spectrum disorder or schizophrenia; CRC cis rs612683 0.518 rs660945 chr1:100831830 A/T cg06223162 chr1:101003688 GPR88 -0.39 -7.26 -0.37 2.78e-12 Breast cancer; CRC cis rs9814567 1.000 rs2887797 chr3:134202506 T/G cg06541857 chr3:134203789 ANAPC13;CEP63 -0.41 -6.31 -0.33 9.05e-10 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC trans rs1814175 0.527 rs7128827 chr11:49665644 C/T cg15704280 chr7:45808275 SEPT13 0.79 10.86 0.51 1.09e-23 Height; CRC cis rs9372498 0.536 rs9489442 chr6:118885950 A/C cg22561889 chr6:118971681 C6orf204 0.5 6.52 0.34 2.71e-10 Diastolic blood pressure; CRC cis rs2932538 0.922 rs12402469 chr1:113076625 G/A cg22162597 chr1:113214053 CAPZA1 0.7 9.66 0.47 1.31e-19 Systolic blood pressure;Diastolic blood pressure;Hypertension;Blood pressure; CRC cis rs6500395 0.962 rs9937568 chr16:48612361 C/T cg04672837 chr16:48644449 N4BP1 -0.42 -5.98 -0.31 5.8e-9 Response to tocilizumab in rheumatoid arthritis; CRC cis rs9894429 1.000 rs7213129 chr17:79581573 C/T cg18240062 chr17:79603768 NPLOC4 0.56 9.34 0.46 1.54e-18 Eye color traits; CRC cis rs7586879 0.639 rs3903070 chr2:25123463 C/G cg22495460 chr2:25135724 ADCY3 -0.87 -17.16 -0.69 1.36e-47 Body mass index; CRC cis rs853679 0.517 rs9393886 chr6:28050039 T/G cg15786705 chr6:28176104 NA 0.74 9.57 0.47 2.68e-19 Depression; CRC cis rs11098499 0.863 rs7664986 chr4:120429952 A/C cg24375607 chr4:120327624 NA 0.47 7.17 0.37 5.06e-12 Corneal astigmatism; CRC cis rs9648716 1.000 rs6464159 chr7:140630266 G/C cg10747023 chr7:140774559 NA 0.46 6.02 0.31 4.76e-9 Type 2 diabetes; CRC cis rs6547741 0.935 rs4666005 chr2:27855239 A/G cg27432699 chr2:27873401 GPN1 0.77 14.05 0.61 1.83e-35 Oral cavity cancer; CRC cis rs10256972 0.521 rs7457418 chr7:1110255 C/T cg07308232 chr7:1071921 C7orf50 -0.44 -6.15 -0.32 2.23e-9 Longevity;Endometriosis; CRC cis rs929354 0.935 rs1182392 chr7:157036200 C/T cg05182265 chr7:156933206 UBE3C 0.64 11.63 0.54 1.99e-26 Body mass index; CRC cis rs35110281 0.667 rs4819291 chr21:45123139 G/A cg21573476 chr21:45109991 RRP1B -0.39 -5.73 -0.3 2.32e-8 Mean corpuscular volume; CRC cis rs7666738 0.830 rs10034330 chr4:99064849 G/A cg17366294 chr4:99064904 C4orf37 0.44 7.47 0.38 7.31e-13 Colonoscopy-negative controls vs population controls; CRC trans rs6703335 0.870 rs10803142 chr1:243598234 A/G cg13949903 chr17:74349974 PRPSAP1 0.42 6.11 0.32 2.8e-9 Schizophrenia;Schizophrenia, schizoaffective disorder or bipolar disorder; CRC trans rs6833159 0.527 rs10939231 chr4:28829372 A/T cg20874811 chr17:54991629 TRIM25 -0.43 -6.15 -0.32 2.28e-9 Underweight status; CRC cis rs853679 1.000 rs853678 chr6:28297313 T/A cg15786705 chr6:28176104 NA 0.55 5.97 0.31 6.08e-9 Depression; CRC cis rs853679 0.517 rs6941992 chr6:28106141 T/C cg15786705 chr6:28176104 NA 0.77 9.75 0.47 6.92e-20 Depression; CRC cis rs2836974 0.568 rs2142111 chr21:40549289 G/C cg11890956 chr21:40555474 PSMG1 0.87 14.28 0.62 2.54e-36 Cognitive function; CRC cis rs17713451 0.593 rs76747376 chr7:151269240 T/C cg18404559 chr7:151322523 PRKAG2 -0.57 -6.41 -0.33 5.12e-10 Interleukin-4 levels; CRC cis rs28386778 0.830 rs7209321 chr17:61855668 A/C cg11494091 chr17:61959527 GH2 0.62 10.37 0.5 5.32e-22 Prudent dietary pattern; CRC cis rs10256972 0.630 rs13235747 chr7:1129123 T/C cg22907277 chr7:1156413 C7orf50 0.67 10.38 0.5 4.99e-22 Longevity;Endometriosis; CRC cis rs597539 0.652 rs546382 chr11:68704264 C/T cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.88 15.09 0.64 1.79e-39 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs6499255 0.904 rs12595927 chr16:69716338 C/G cg15192750 chr16:69999425 NA 0.59 7.48 0.38 6.93e-13 IgE levels; CRC trans rs4942242 0.602 rs61960076 chr13:44217784 T/C cg26741380 chr15:41871084 TYRO3 -0.45 -6.24 -0.33 1.34e-9 Response to tocilizumab in rheumatoid arthritis; CRC cis rs7258465 0.965 rs8100767 chr19:18589088 T/C cg06462663 chr19:18546047 ISYNA1 0.48 7.36 0.38 1.47e-12 Breast cancer; CRC cis rs4713118 0.666 rs2893930 chr6:27738806 T/C cg03623178 chr6:28175578 NA 0.75 8.28 0.42 3.23e-15 Parkinson's disease; CRC cis rs1178968 1.000 rs7793764 chr7:72759953 G/T cg25889504 chr7:72793014 NA 0.48 5.65 0.3 3.42e-8 Triglyceride levels; CRC cis rs11608355 0.515 rs12822282 chr12:109923207 G/A cg05360138 chr12:110035743 NA 0.78 8.76 0.43 1.07e-16 Neuroticism; CRC cis rs6674970 0.518 rs6587552 chr1:151018861 C/T cg03258749 chr1:151040405 MLLT11 0.55 8.5 0.42 6.71e-16 Childhood ear infection; CRC cis rs11645898 0.935 rs4788605 chr16:72154682 G/T cg14768367 chr16:72042858 DHODH -0.6 -6.73 -0.35 7.7e-11 Blood protein levels; CRC cis rs981844 0.689 rs7666762 chr4:154684197 C/T cg10279832 chr4:154682576 RNF175 0.38 5.63 0.3 3.89e-8 Response to statins (LDL cholesterol change); CRC cis rs3617 0.532 rs9836499 chr3:52904524 G/T cg18099408 chr3:52552593 STAB1 0.33 5.62 0.3 4.05e-8 Red blood cell count;Autism spectrum disorder or schizophrenia; CRC cis rs11792861 0.926 rs1333344 chr9:111776224 C/T cg05043794 chr9:111880884 C9orf5 -0.35 -6.3 -0.33 9.68e-10 Menarche (age at onset); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg04027074 chr6:144471431 STX11 0.38 6.31 0.33 8.81e-10 Liver disease severity in Alagille syndrome; CRC cis rs679087 0.686 rs10843500 chr12:29918582 C/G cg14258853 chr12:29935411 TMTC1 0.36 6.79 0.35 5.29e-11 Schizophrenia; CRC cis rs9372498 0.505 rs9489493 chr6:118992323 T/C cg01339444 chr6:118972232 C6orf204 0.49 5.92 0.31 8.04e-9 Diastolic blood pressure; CRC cis rs12928939 0.517 rs11865456 chr16:71969497 C/T cg03805757 chr16:71968109 PKD1L3 -0.54 -7.29 -0.37 2.28e-12 Post bronchodilator FEV1; CRC cis rs2455601 0.935 rs12049908 chr11:8919309 G/A cg21881798 chr11:8931708 C11orf17;ST5 -0.54 -6.02 -0.31 4.77e-9 Schizophrenia; CRC cis rs972578 1.000 rs5751405 chr22:43361079 G/A cg01576275 chr22:43409880 NA -0.44 -7.14 -0.37 6.09e-12 Mean platelet volume; CRC cis rs4665809 0.793 rs6546715 chr2:26261520 G/A cg27170947 chr2:26402098 FAM59B -0.44 -5.89 -0.31 9.43e-9 Gut microbiome composition (summer); CRC cis rs3785574 0.962 rs2665799 chr17:61919723 A/G cg06601766 chr17:61851465 DDX42;CCDC47 0.6 8.4 0.42 1.38e-15 Height; CRC cis rs908922 0.676 rs4240887 chr1:152530510 C/T cg23254163 chr1:152506842 NA -0.45 -9.14 -0.45 6.49e-18 Hair morphology; CRC cis rs11155671 0.530 rs4458704 chr6:150232879 A/C cg07701084 chr6:150067640 NUP43 0.4 5.83 0.31 1.33e-8 Testicular germ cell tumor; CRC cis rs7258465 1.000 rs8103622 chr19:18572834 C/T cg01065977 chr19:18549689 ISYNA1 -0.41 -6.35 -0.33 7.26e-10 Breast cancer; CRC cis rs7119 0.717 rs12912386 chr15:77817640 T/C cg10437265 chr15:77819839 NA 0.69 12.74 0.57 1.76e-30 Type 2 diabetes; CRC cis rs9894429 0.538 rs9747080 chr17:79606704 A/G cg18240062 chr17:79603768 NPLOC4 0.57 9.62 0.47 1.79e-19 Eye color traits; CRC cis rs62408225 1.000 rs1847472 chr6:90973159 A/C cg06866423 chr6:90926672 BACH2 -0.52 -8.77 -0.44 9.7e-17 Eosinophil counts;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC cis rs78456975 1.000 rs11898988 chr2:1560336 G/A cg12573674 chr2:1569213 NA -0.77 -8.05 -0.41 1.51e-14 Placebo response in major depressive disorder (% change in symptom score); CRC cis rs2274273 0.935 rs8004787 chr14:55607366 C/T cg23234261 chr14:55582407 NA -0.3 -5.91 -0.31 8.58e-9 Protein biomarker; CRC cis rs34375054 0.573 rs12581813 chr12:125656402 A/G cg02766259 chr12:125626809 AACS -0.44 -6.14 -0.32 2.38e-9 Post bronchodilator FEV1/FVC ratio; CRC trans rs2727020 0.658 rs10839269 chr11:49385596 A/G cg15704280 chr7:45808275 SEPT13 -0.92 -17.3 -0.69 3.99e-48 Coronary artery disease; CRC cis rs4731207 0.565 rs4355714 chr7:124627521 T/G cg23710748 chr7:124431027 NA -0.39 -6.26 -0.33 1.22e-9 Cutaneous malignant melanoma; CRC cis rs3096299 0.728 rs1011749 chr16:89510869 G/C cg01788221 chr16:89496183 ANKRD11 -0.44 -6.57 -0.34 1.94e-10 Multiple myeloma (IgH translocation); CRC cis rs4665809 1.000 rs4665309 chr2:26335502 T/C cg04944784 chr2:26401820 FAM59B -0.6 -7.67 -0.39 1.98e-13 Gut microbiome composition (summer); CRC cis rs10751667 0.961 rs7482484 chr11:927020 C/T cg23136738 chr11:925521 AP2A2 -0.5 -7.94 -0.4 3.32e-14 Alzheimer's disease (late onset); CRC cis rs6724607 0.905 rs7603849 chr2:191438741 A/C cg10560079 chr2:191398806 TMEM194B 0.47 6.71 0.35 8.66e-11 Pulse pressure; CRC cis rs7949030 0.626 rs72927213 chr11:62351198 G/C cg13298116 chr11:62369859 EML3;MTA2 0.63 10.9 0.52 7.95e-24 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; CRC cis rs10392 0.543 rs62204117 chr20:37565335 T/C cg27552599 chr20:37590471 DHX35 0.37 5.71 0.3 2.55e-8 Alcohol dependence or chronic alcoholic pancreatitis or alcohol-related liver cirrhosis; CRC cis rs7695597 0.708 rs7680050 chr4:185181276 C/T cg18317788 chr4:185205197 NA -0.34 -5.69 -0.3 2.8e-8 Night sleep phenotypes; CRC cis rs10484885 0.878 rs55750696 chr6:90552336 G/A cg13799429 chr6:90582589 CASP8AP2 -0.72 -7.69 -0.39 1.76e-13 QRS interval (sulfonylurea treatment interaction); CRC cis rs1218582 0.741 rs6656494 chr1:154839799 A/G cg06221963 chr1:154839813 KCNN3 -0.82 -17.71 -0.7 8.87e-50 Prostate cancer; CRC cis rs1865760 1.000 rs6938233 chr6:25914077 C/T cg17691542 chr6:26056736 HIST1H1C 0.56 8.43 0.42 1.1e-15 Height; CRC trans rs1814175 0.791 rs10219223 chr11:49791468 A/T cg15704280 chr7:45808275 SEPT13 -0.98 -19.12 -0.73 2.57e-55 Height; CRC cis rs9467711 0.538 rs13214169 chr6:25890656 A/G cg08501292 chr6:25962987 TRIM38 1.01 9.29 0.46 2.17e-18 Autism spectrum disorder or schizophrenia; CRC cis rs17376456 0.877 rs9314100 chr5:93447394 T/C cg21475434 chr5:93447410 FAM172A 0.75 7.65 0.39 2.18e-13 Diabetic retinopathy; CRC trans rs2727020 0.634 rs11040331 chr11:49345726 T/C cg15704280 chr7:45808275 SEPT13 -0.69 -8.81 -0.44 7.09e-17 Coronary artery disease; CRC cis rs12479064 0.724 rs11885942 chr2:100004165 A/G cg26064155 chr2:99771622 LIPT1;TSGA10 -0.62 -7.41 -0.38 1.05e-12 Chronic sinus infection; CRC trans rs11098499 0.954 rs6849561 chr4:120409694 C/G cg25214090 chr10:38739885 LOC399744 -0.65 -9.93 -0.48 1.7e-20 Corneal astigmatism; CRC cis rs6087990 0.735 rs2424920 chr20:31385452 T/C cg13636640 chr20:31349939 DNMT3B 0.76 13.82 0.61 1.43e-34 Ulcerative colitis; CRC trans rs3942852 0.696 rs4597030 chr11:48176573 G/A cg15704280 chr7:45808275 SEPT13 -0.75 -9.35 -0.46 1.43e-18 Acute lymphoblastic leukemia (childhood); CRC cis rs1816752 0.713 rs7336357 chr13:25017590 T/C cg02811702 chr13:24901961 NA 0.48 6.6 0.34 1.68e-10 Obesity-related traits; CRC trans rs6601327 0.613 rs4612345 chr8:9580001 A/G cg06636001 chr8:8085503 FLJ10661 -0.49 -7.07 -0.36 9.21e-12 Multiple myeloma (hyperdiploidy); CRC trans rs7615952 0.866 rs6438949 chr3:125650064 G/C cg07211511 chr3:129823064 LOC729375 -1.07 -18.37 -0.71 2.34e-52 Blood pressure (smoking interaction); CRC cis rs7659604 0.967 rs34949254 chr4:122664344 G/A cg06713675 chr4:122721982 EXOSC9 -0.38 -6.27 -0.33 1.13e-9 Type 2 diabetes; CRC cis rs1580019 0.539 rs11769109 chr7:32571352 A/G cg06627557 chr7:32535165 LSM5;AVL9 0.96 18.16 0.71 1.53e-51 Cognitive ability; CRC cis rs12024301 0.557 rs6673809 chr1:183603060 A/C cg11505048 chr1:183622726 RGL1;APOBEC4 -0.72 -6.4 -0.33 5.33e-10 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs1971762 0.583 rs3852561 chr12:54085842 C/T cg06632207 chr12:54070931 ATP5G2 0.39 6.72 0.35 8.14e-11 Height; CRC cis rs4319547 0.737 rs10846920 chr12:122943231 C/T cg23029597 chr12:123009494 RSRC2 -0.45 -5.98 -0.31 5.84e-9 Body mass index; CRC cis rs9388451 0.591 rs1268792 chr6:126042124 G/A cg05901451 chr6:126070800 HEY2 0.49 7.96 0.4 2.83e-14 Brugada syndrome; CRC cis rs6662572 0.703 rs4660909 chr1:46477326 G/C cg08644498 chr1:46502608 NA -0.47 -7.46 -0.38 7.64e-13 Blood protein levels; CRC cis rs2307022 0.542 rs4783624 chr16:68409947 T/C cg02226672 chr16:68398533 SMPD3 0.29 5.69 0.3 2.86e-8 Body mass index; CRC trans rs7647973 0.626 rs7649428 chr3:49868876 A/T cg21659725 chr3:3221576 CRBN 0.67 7.26 0.37 2.87e-12 Menarche (age at onset); CRC cis rs7692995 1.000 rs16896245 chr4:18005608 C/T cg08925142 chr4:18023851 LCORL -0.55 -6.06 -0.32 3.73e-9 Height; CRC trans rs2055729 0.601 rs12546952 chr8:9744002 G/C cg06636001 chr8:8085503 FLJ10661 -0.58 -7.27 -0.37 2.65e-12 Multiple myeloma (hyperdiploidy); CRC cis rs425277 0.916 rs414777 chr1:2101687 G/A cg24578937 chr1:2090814 PRKCZ 0.66 11.75 0.54 7.39e-27 Height; CRC cis rs763121 0.853 rs138702 chr22:39132601 A/T cg06022373 chr22:39101656 GTPBP1 -0.79 -13.11 -0.59 7.1e-32 Menopause (age at onset); CRC cis rs4478858 0.662 rs6425735 chr1:31783945 T/C cg00250761 chr1:31883323 NA -0.38 -7.06 -0.36 9.67e-12 Alcohol dependence; CRC cis rs7259376 0.871 rs2360622 chr19:22570622 T/C cg02657401 chr19:22469223 NA -0.32 -7.0 -0.36 1.48e-11 Menopause (age at onset); CRC cis rs11122272 0.735 rs2749705 chr1:231526696 C/T cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.58 -8.56 -0.43 4.43e-16 Hemoglobin concentration; CRC cis rs1953600 0.870 rs2245168 chr10:81921918 T/C cg00277334 chr10:82204260 NA -0.37 -6.02 -0.32 4.54e-9 Sarcoidosis; CRC cis rs798554 0.591 rs757791 chr7:2867296 A/G cg19717773 chr7:2847554 GNA12 -0.43 -7.24 -0.37 3.26e-12 Height; CRC cis rs11585357 0.709 rs735281 chr1:17616194 T/C cg08277548 chr1:17600880 PADI3 0.65 9.04 0.45 1.36e-17 Hair shape; CRC cis rs798554 0.679 rs11973498 chr7:2886873 C/A cg19346786 chr7:2764209 NA -0.37 -6.43 -0.33 4.4e-10 Height; CRC cis rs7044106 0.791 rs10760116 chr9:123494681 C/T cg14255062 chr9:123606675 PSMD5;LOC253039 0.51 7.73 0.39 1.31e-13 Hip circumference adjusted for BMI; CRC cis rs2456568 0.771 rs8181530 chr11:93638678 G/A cg26875233 chr11:93583750 C11orf90 -0.31 -6.03 -0.32 4.38e-9 Response to serotonin reuptake inhibitors in major depressive disorder; CRC trans rs9868809 0.881 rs13096357 chr3:48675856 C/A cg03060546 chr3:49711283 APEH -0.59 -6.3 -0.33 9.33e-10 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; CRC cis rs8177253 0.574 rs6775042 chr3:133442245 G/T cg01448562 chr3:133502909 NA -0.35 -5.79 -0.3 1.67e-8 Iron status biomarkers; CRC cis rs9303280 0.806 rs12232498 chr17:38040363 T/C cg11212589 chr17:38028394 ZPBP2 0.43 7.95 0.4 2.96e-14 Self-reported allergy; CRC cis rs394563 0.967 rs420099 chr6:149794290 A/C cg11245181 chr6:149772854 ZC3H12D -0.55 -9.07 -0.45 1.12e-17 Dupuytren's disease; CRC cis rs1552244 0.882 rs34779351 chr3:10021801 A/G cg02579736 chr3:10068473 FANCD2;CIDECP 0.93 11.94 0.55 1.55e-27 Alzheimer's disease; CRC cis rs1552244 0.572 rs3894322 chr3:10168965 G/A cg13047869 chr3:10149882 C3orf24 0.53 6.49 0.34 3.25e-10 Alzheimer's disease; CRC cis rs8077889 0.917 rs72836559 chr17:41913529 C/T cg16892393 chr17:41919603 NA 0.6 8.63 0.43 2.61e-16 Triglycerides; CRC cis rs873946 0.504 rs4880275 chr10:134576552 C/T cg27286337 chr10:134555280 INPP5A 0.71 9.27 0.46 2.53e-18 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CRC cis rs28493229 0.708 rs78900506 chr19:41160096 T/C cg21869046 chr19:41225005 ITPKC 0.4 6.06 0.32 3.69e-9 Kawasaki disease; CRC cis rs9611565 0.659 rs56319767 chr22:41933837 G/A cg06634786 chr22:41940651 POLR3H -0.7 -8.13 -0.41 8.97e-15 Vitiligo; CRC cis rs6479527 0.904 rs3847307 chr9:96865638 C/T cg14459158 chr9:96720562 NA 0.37 6.74 0.35 7.29e-11 Esophageal adenocarcinoma; CRC cis rs941873 0.835 rs10762859 chr10:81103370 T/A cg09469691 chr10:81107165 PPIF 0.51 8.03 0.4 1.8e-14 Height; CRC cis rs2243480 1.000 rs458291 chr7:65520479 C/A cg25985355 chr7:65971099 NA -0.54 -6.07 -0.32 3.54e-9 Diabetic kidney disease; CRC cis rs7635838 0.686 rs347589 chr3:11288419 A/G cg00170343 chr3:11313890 ATG7 0.55 8.36 0.42 1.83e-15 HDL cholesterol; CRC cis rs853679 0.527 rs9468333 chr6:28271198 C/T cg03623178 chr6:28175578 NA 0.48 6.66 0.34 1.17e-10 Depression; CRC cis rs4478858 0.684 rs4949374 chr1:31754511 G/C cg00250761 chr1:31883323 NA -0.43 -8.37 -0.42 1.68e-15 Alcohol dependence; CRC cis rs10504229 0.728 rs17804624 chr8:58154216 T/C cg05313129 chr8:58192883 C8orf71 -0.47 -6.18 -0.32 1.94e-9 Developmental language disorder (linguistic errors); CRC cis rs1403694 0.515 rs1648697 chr3:186449194 A/G cg04611788 chr3:186434169 KNG1 -0.57 -8.32 -0.42 2.41e-15 Blood protein levels; CRC cis rs7707921 0.690 rs6870335 chr5:81590070 A/T cg07807695 chr5:81608485 ATP6AP1L 0.47 7.38 0.38 1.3e-12 Breast cancer; CRC cis rs7666738 0.830 rs13125930 chr4:98654695 G/A cg17366294 chr4:99064904 C4orf37 0.35 5.7 0.3 2.66e-8 Colonoscopy-negative controls vs population controls; CRC cis rs172166 0.516 rs1150670 chr6:28130559 A/G cg12172441 chr6:28176163 NA 0.45 6.55 0.34 2.25e-10 Cardiac Troponin-T levels; CRC cis rs526821 0.595 rs624478 chr11:55340778 C/G cg04317927 chr11:55418816 OR4S2 0.38 6.55 0.34 2.21e-10 Pediatric bone mineral density (spine); CRC cis rs9326248 0.861 rs7931335 chr11:117036805 C/T cg26566898 chr11:117069891 TAGLN 0.38 6.89 0.36 2.79e-11 Blood protein levels; CRC cis rs951366 0.764 rs823141 chr1:205741426 T/C cg11965913 chr1:205819406 PM20D1 0.84 13.86 0.61 1e-34 Menarche (age at onset); CRC cis rs2228479 0.850 rs3785281 chr16:89824263 G/C cg06558623 chr16:89946397 TCF25 1.13 10.45 0.5 2.85e-22 Skin colour saturation; CRC cis rs644799 0.544 rs56298021 chr11:95545113 T/G cg03916912 chr11:95522834 CEP57;FAM76B 0.71 11.73 0.54 8.59e-27 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg15212440 chr10:104474465 SFXN2;ARL3 0.42 6.02 0.31 4.61e-9 Response to antipsychotic treatment; CRC cis rs9649213 0.593 rs3801256 chr7:97992095 C/G cg08684580 chr7:98029266 BAIAP2L1 -0.32 -5.67 -0.3 3.09e-8 Prostate cancer (SNP x SNP interaction); CRC cis rs2019137 0.936 rs12612729 chr2:113957048 G/A cg12889195 chr2:113992843 PAX8;LOC440839;LOC654433 -0.51 -7.23 -0.37 3.32e-12 Lymphocyte counts; CRC cis rs6585424 1.000 rs11202031 chr10:81944043 G/C cg11900509 chr10:81946545 ANXA11 -0.72 -8.58 -0.43 3.83e-16 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs561341 1.000 rs7216102 chr17:30259450 A/G cg19193384 chr17:30244184 NA -0.49 -6.69 -0.35 9.5e-11 Hip circumference adjusted for BMI; CRC cis rs9534288 0.716 rs2573304 chr13:46514642 C/T cg15192986 chr13:46630673 CPB2 0.68 9.55 0.47 3.05e-19 Blood protein levels; CRC trans rs7762018 0.660 rs41265385 chr6:170068086 C/T cg06875740 chr19:51307921 C19orf48 -0.66 -6.0 -0.31 5.19e-9 Thiazide-induced adverse metabolic effects in hypertensive patients; CRC trans rs10982213 0.830 rs2274163 chr9:117188714 C/T cg25842470 chr1:2472373 NA -0.41 -6.19 -0.32 1.8e-9 Interleukin-6 levels; CRC trans rs208520 1.000 rs208535 chr6:66962286 G/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.89 -11.02 -0.52 2.96e-24 Exhaled nitric oxide output; CRC cis rs4862750 0.832 rs10007858 chr4:187877492 A/G cg03647317 chr4:187891568 NA -0.54 -10.18 -0.49 2.45e-21 Lobe attachment (rater-scored or self-reported); CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg01457183 chr3:180707371 DNAJC19 -0.4 -6.27 -0.33 1.16e-9 Myopia (pathological); CRC cis rs6424115 0.830 rs2502991 chr1:24202318 A/G cg15997130 chr1:24165203 NA 0.73 10.74 0.51 2.79e-23 Immature fraction of reticulocytes; CRC trans rs5756813 0.646 rs3788528 chr22:38146433 T/C cg19894588 chr14:64061835 NA 0.49 6.48 0.34 3.37e-10 Optic cup area;Vertical cup-disc ratio; CRC cis rs4478858 0.663 rs11591060 chr1:31780012 G/A cg00250761 chr1:31883323 NA -0.38 -7.23 -0.37 3.44e-12 Alcohol dependence; CRC cis rs7538876 0.903 rs6688886 chr1:17753639 G/A cg01904812 chr1:17746340 RCC2 0.36 5.85 0.31 1.16e-8 Basal cell carcinoma; CRC cis rs13315871 1.000 rs4075403 chr3:58411445 G/C cg20936604 chr3:58311152 NA -0.76 -7.15 -0.37 5.74e-12 Cholesterol, total; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg08883955 chr16:11945066 RSL1D1 0.54 6.89 0.36 2.83e-11 Thyroid stimulating hormone; CRC cis rs477895 0.652 rs72920332 chr11:63947071 G/T cg19465662 chr11:63993652 NUDT22;TRPT1 0.72 8.91 0.44 3.46e-17 Mean platelet volume; CRC cis rs17234274 0.500 rs1384489 chr11:23225422 C/G cg16745844 chr11:23258850 NA -0.33 -5.86 -0.31 1.14e-8 Cancer; CRC cis rs9611565 0.802 rs9611577 chr22:41793090 T/G cg06481639 chr22:41940642 POLR3H -0.49 -5.72 -0.3 2.34e-8 Vitiligo; CRC cis rs4072980 0.527 rs11210825 chr1:38446986 G/A cg12658694 chr1:38397304 INPP5B 0.42 5.93 0.31 7.62e-9 Coronary artery disease; CRC cis rs4803468 0.967 rs11670583 chr19:41920440 A/T cg09537434 chr19:41945824 ATP5SL -0.97 -18.81 -0.72 4.3e-54 Height; CRC trans rs11039798 0.623 rs7294273 chr11:48705374 T/C cg15704280 chr7:45808275 SEPT13 0.66 6.81 0.35 4.72e-11 Axial length; CRC trans rs7824557 0.806 rs10503418 chr8:11118983 C/T cg06636001 chr8:8085503 FLJ10661 -0.45 -6.53 -0.34 2.43e-10 Retinal vascular caliber; CRC cis rs7119 0.651 rs12915057 chr15:77847745 C/A cg27398640 chr15:77910606 LINGO1 -0.41 -6.83 -0.35 4.04e-11 Type 2 diabetes; CRC cis rs9303280 0.806 rs12709365 chr17:38027400 A/G cg20243544 chr17:37824526 PNMT 0.38 5.73 0.3 2.28e-8 Self-reported allergy; CRC cis rs853679 0.550 rs1150692 chr6:28173957 A/G cg03623178 chr6:28175578 NA 0.93 13.55 0.6 1.58e-33 Depression; CRC cis rs6840360 1.000 rs7663045 chr4:152676350 T/C cg09659197 chr4:152720779 NA 0.53 11.71 0.54 1.01e-26 Intelligence (multi-trait analysis); CRC cis rs1887596 0.629 rs1625599 chr13:27257688 C/T cg01312412 chr13:27282625 NA -0.44 -5.96 -0.31 6.54e-9 Facial morphology (factor 3, length of philtrum); CRC cis rs7412746 0.611 rs12085336 chr1:150775780 A/T cg10589385 chr1:150898437 SETDB1 0.28 5.89 0.31 9.36e-9 Melanoma; CRC cis rs7726839 0.794 rs11739663 chr5:594083 A/G cg16447950 chr5:562315 NA -0.54 -8.21 -0.41 5.21e-15 Obesity-related traits; CRC cis rs56235845 0.694 rs6860069 chr5:176755841 C/T cg06060754 chr5:176797920 RGS14 0.55 8.68 0.43 1.82e-16 Hemoglobin concentration;Hematocrit; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg02615599 chr7:150725389 ABCB8 0.44 6.4 0.33 5.41e-10 Intelligence (multi-trait analysis); CRC cis rs9398803 0.830 rs1415671 chr6:126759587 T/G cg19875578 chr6:126661172 C6orf173 0.42 5.94 0.31 7.34e-9 Male-pattern baldness; CRC cis rs6840360 0.615 rs6535816 chr4:152614264 T/C cg09659197 chr4:152720779 NA 0.42 8.32 0.42 2.35e-15 Intelligence (multi-trait analysis); CRC cis rs763121 0.853 rs2072798 chr22:39148483 G/A cg06544989 chr22:39130855 UNC84B 0.46 6.82 0.35 4.44e-11 Menopause (age at onset); CRC cis rs9547692 0.938 rs17217404 chr13:37466215 C/T cg01493522 chr13:37497338 NA -0.55 -7.43 -0.38 9.46e-13 Coronary artery disease; CRC cis rs7020830 0.931 rs3802422 chr9:37097172 G/A cg14294708 chr9:37120828 ZCCHC7 1.18 26.37 0.82 3.89e-83 Schizophrenia; CRC cis rs7615952 0.599 rs6766327 chr3:125723677 C/G cg15145296 chr3:125709740 NA -0.6 -7.07 -0.36 9.42e-12 Blood pressure (smoking interaction); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg03398387 chr6:160114178 SOD2 0.44 6.31 0.33 9.23e-10 Intelligence (multi-trait analysis); CRC cis rs17125944 0.505 rs2274275 chr14:53235728 G/T cg00686598 chr14:53173677 PSMC6 1.23 11.44 0.53 9.66e-26 Alzheimer's disease (late onset); CRC cis rs7127900 0.614 rs11564708 chr11:2206326 C/G cg20200711 chr11:2211776 NA 0.47 6.55 0.34 2.19e-10 Prostate cancer;Prostate cancer (SNP x SNP interaction);Prostate cancer (early onset); CRC cis rs8060686 0.920 rs111315946 chr16:67889793 G/C cg06138825 chr16:67683817 RLTPR -0.52 -5.71 -0.3 2.47e-8 HDL cholesterol;Metabolic syndrome; CRC cis rs9487051 0.646 rs9487049 chr6:109615905 A/T cg01475377 chr6:109611718 NA -0.36 -5.64 -0.3 3.69e-8 Reticulocyte fraction of red cells; CRC trans rs2303319 0.504 rs62189041 chr2:162599506 T/C cg27342122 chr8:133787442 PHF20L1 -0.72 -6.12 -0.32 2.68e-9 Cognitive function; CRC trans rs11039798 0.588 rs6485891 chr11:48612024 T/A cg15704280 chr7:45808275 SEPT13 0.66 6.97 0.36 1.74e-11 Axial length; CRC cis rs7208859 0.623 rs73263788 chr17:29216490 T/C cg13385521 chr17:29058706 SUZ12P 0.65 7.62 0.39 2.68e-13 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs1448094 0.512 rs6539926 chr12:86244460 G/A cg18827107 chr12:86230957 RASSF9 -0.45 -7.42 -0.38 9.97e-13 Major depressive disorder; CRC cis rs4604732 0.578 rs7525209 chr1:247627404 C/T cg12754571 chr1:247694271 LOC148824;OR2C3 0.41 5.78 0.3 1.74e-8 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CRC cis rs6066835 1.000 rs6095244 chr20:47318774 T/C cg18078177 chr20:47281410 PREX1 0.68 5.67 0.3 3.09e-8 Multiple myeloma; CRC cis rs798554 0.757 rs1182185 chr7:2872233 A/G cg14863265 chr7:2801509 GNA12 -0.4 -5.8 -0.3 1.53e-8 Height; CRC cis rs853679 0.517 rs9380047 chr6:28037893 G/T cg15786705 chr6:28176104 NA 0.74 9.35 0.46 1.41e-18 Depression; CRC cis rs7208859 0.673 rs79541516 chr17:29240583 C/T cg01831904 chr17:28903510 LRRC37B2 -0.56 -5.82 -0.31 1.38e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg26098650 chr11:120207939 ARHGEF12 0.47 7.55 0.38 4.23e-13 Response to antipsychotic treatment; CRC cis rs1218582 0.774 rs4845683 chr1:154877407 T/C cg24250549 chr1:154909240 PMVK 0.59 9.6 0.47 2.13e-19 Prostate cancer; CRC trans rs9393777 0.920 rs35120058 chr6:27358166 A/G cg06606381 chr12:133084897 FBRSL1 -1.14 -7.72 -0.39 1.43e-13 Intelligence (multi-trait analysis); CRC cis rs79839061 0.610 rs9994159 chr4:891150 C/T cg14530993 chr4:882597 GAK 0.79 7.62 0.39 2.68e-13 Intelligence (multi-trait analysis); CRC cis rs62064224 0.614 rs728718 chr17:30708960 T/G cg21839984 chr17:30846986 MYO1D -0.33 -5.64 -0.3 3.68e-8 Schizophrenia; CRC cis rs1580019 0.563 rs34319173 chr7:32585904 G/A cg14728415 chr7:32535168 LSM5;AVL9 0.45 6.39 0.33 5.7e-10 Cognitive ability; CRC cis rs9403521 0.580 rs9376772 chr6:143960454 T/C cg18240653 chr6:144019428 PHACTR2 -0.56 -5.69 -0.3 2.74e-8 Obesity-related traits; CRC cis rs6502050 0.769 rs4789741 chr17:80119184 A/C cg19223190 chr17:80058835 NA 0.39 6.17 0.32 2.02e-9 Life satisfaction; CRC cis rs71403859 0.730 rs17356206 chr16:71736359 G/C cg08717414 chr16:71523259 ZNF19 -1.01 -9.03 -0.45 1.47e-17 Post bronchodilator FEV1; CRC cis rs6062302 0.522 rs3787112 chr20:62222411 G/A cg16989086 chr20:62203971 PRIC285 0.47 6.04 0.32 4.09e-9 Glioblastoma; CRC cis rs6582630 0.615 rs12821226 chr12:38546406 C/T cg13010199 chr12:38710504 ALG10B -0.42 -6.05 -0.32 3.97e-9 Drug-induced liver injury (flucloxacillin); CRC cis rs2075371 0.501 rs1646652 chr7:134024515 A/T cg02659138 chr7:134003124 SLC35B4 0.37 6.28 0.33 1.06e-9 Mean platelet volume; CRC cis rs875971 0.862 rs6460306 chr7:66060793 T/C cg18876405 chr7:65276391 NA -0.53 -8.56 -0.43 4.34e-16 Aortic root size; CRC cis rs13108904 0.539 rs13140926 chr4:1340939 G/A cg02018176 chr4:1364513 KIAA1530 0.4 5.74 0.3 2.15e-8 Obesity-related traits; CRC cis rs13315871 1.000 rs1131052 chr3:58411530 A/T cg20936604 chr3:58311152 NA -0.76 -7.15 -0.37 5.74e-12 Cholesterol, total; CRC cis rs2739330 0.796 rs1006771 chr22:24314006 G/T cg23131131 chr22:24373011 LOC391322 -0.67 -10.82 -0.51 1.53e-23 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs2576037 0.526 rs6507714 chr18:44519574 A/G cg19077165 chr18:44547161 KATNAL2 -0.51 -7.69 -0.39 1.76e-13 Personality dimensions; CRC cis rs10791323 0.511 rs4937837 chr11:133731134 T/C cg03690763 chr11:133734501 NA -0.39 -6.38 -0.33 6.1e-10 Childhood ear infection; CRC cis rs12497850 0.864 rs4513485 chr3:49139966 G/A cg03060546 chr3:49711283 APEH 0.41 5.86 0.31 1.13e-8 Parkinson's disease; CRC cis rs1348850 0.914 rs7604673 chr2:178392346 A/G cg22681709 chr2:178499509 PDE11A -0.38 -6.86 -0.35 3.47e-11 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs11190604 1.000 rs4919469 chr10:102298855 C/A cg16342193 chr10:102329863 NA -0.36 -5.99 -0.31 5.62e-9 Palmitoleic acid (16:1n-7) levels; CRC cis rs3857067 1.000 rs3846292 chr4:95027717 G/T cg11021082 chr4:95130006 SMARCAD1 -0.41 -6.22 -0.32 1.55e-9 QT interval; CRC trans rs1814175 0.715 rs10839409 chr11:49884647 G/T cg03929089 chr4:120376271 NA -0.97 -19.03 -0.72 5.79e-55 Height; CRC cis rs12230513 0.732 rs7971742 chr12:55848486 A/G cg19537932 chr12:55886519 OR6C68 -0.72 -9.44 -0.46 7.08e-19 Contrast sensitivity; CRC trans rs116095464 0.558 rs10057626 chr5:239720 T/G cg00938859 chr5:1591904 SDHAP3 0.74 7.94 0.4 3.13e-14 Breast cancer; CRC trans rs7821565 0.904 rs57224283 chr8:52164724 G/A cg09187163 chr7:72721838 NSUN5 -0.41 -5.98 -0.31 5.79e-9 Tuberculosis; CRC cis rs12497850 1.000 rs4858831 chr3:48735558 C/T cg07636037 chr3:49044803 WDR6 0.92 15.54 0.65 3.3e-41 Parkinson's disease; CRC cis rs10206020 0.921 rs11884956 chr2:1566426 A/G cg26248373 chr2:1572462 NA -0.86 -12.67 -0.57 3.01e-30 IgG glycosylation; CRC cis rs9549328 0.565 rs35371379 chr13:113616715 T/C cg24588162 chr13:113633484 MCF2L 0.36 6.4 0.33 5.22e-10 Systolic blood pressure; CRC cis rs10540 1.000 rs61876335 chr11:488878 T/C cg03352830 chr11:487213 PTDSS2 0.65 7.94 0.4 3.19e-14 Body mass index; CRC cis rs1322512 0.958 rs74608294 chr6:152944818 T/C cg03415253 chr6:152958462 SYNE1 -0.41 -6.38 -0.33 6.06e-10 Tonometry; CRC cis rs6951245 0.706 rs28483034 chr7:1170171 C/A cg24642844 chr7:1081250 C7orf50 -0.68 -8.58 -0.43 3.77e-16 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs11997175 0.646 rs4733180 chr8:33700520 C/T cg04338863 chr8:33670619 NA 0.42 6.72 0.35 8.03e-11 Body mass index; CRC cis rs77956314 0.515 rs60940473 chr12:117462582 C/T cg02017074 chr12:117425053 FBXW8 -0.62 -7.7 -0.39 1.63e-13 Subcortical brain region volumes;Hippocampal volume; CRC cis rs9660992 0.573 rs1172161 chr1:205206495 C/T cg03948781 chr1:205179583 DSTYK 0.41 5.6 0.3 4.5e-8 Mean corpuscular volume;Mean platelet volume; CRC cis rs736408 0.688 rs2239551 chr3:52818579 A/G cg05573699 chr3:52720067 GNL3;PBRM1 0.43 6.03 0.32 4.53e-9 Bipolar disorder; CRC cis rs6502050 0.787 rs11653012 chr17:80058857 C/T cg02741985 chr17:80059408 CCDC57 -0.46 -7.78 -0.39 9.53e-14 Life satisfaction; CRC cis rs17739167 0.550 rs6493013 chr15:42224824 T/C cg20935245 chr15:42234343 EHD4 0.43 6.61 0.34 1.53e-10 Monocyte count; CRC cis rs9399137 0.507 rs13064 chr6:135287533 A/G cg22676075 chr6:135203613 NA 0.59 8.87 0.44 4.64e-17 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; CRC cis rs1707322 0.963 rs4508055 chr1:46257731 A/T cg03146154 chr1:46216737 IPP 0.61 8.53 0.43 5.32e-16 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs12286929 0.607 rs10891808 chr11:115071301 T/C cg04055981 chr11:115044050 NA -0.42 -6.8 -0.35 4.87e-11 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs1865760 0.865 rs4478388 chr6:25953633 A/G cg17691542 chr6:26056736 HIST1H1C 0.55 8.29 0.42 2.87e-15 Height; CRC cis rs7020830 0.861 rs13295981 chr9:37330067 C/T cg14294708 chr9:37120828 ZCCHC7 1.17 26.69 0.83 2.66e-84 Schizophrenia; CRC cis rs11190604 1.000 rs2495753 chr10:102325640 C/T cg16342193 chr10:102329863 NA -0.39 -6.31 -0.33 9.24e-10 Palmitoleic acid (16:1n-7) levels; CRC cis rs4523957 0.855 rs12603057 chr17:2112567 T/C cg16513277 chr17:2031491 SMG6 -0.52 -8.51 -0.42 6.2e-16 Autism spectrum disorder or schizophrenia;Schizophrenia; CRC cis rs2949837 0.581 rs1496499 chr7:45979023 T/G cg04727332 chr7:45960243 IGFBP3 0.37 5.88 0.31 1e-8 Sitting height ratio; CRC cis rs7927771 0.524 rs10742820 chr11:47781057 C/T cg20307385 chr11:47447363 PSMC3 -0.45 -6.64 -0.34 1.28e-10 Subjective well-being; CRC cis rs2179367 0.959 rs237034 chr6:149711862 A/C cg11245181 chr6:149772854 ZC3H12D -0.41 -6.18 -0.32 1.93e-9 Dupuytren's disease; CRC cis rs6502050 0.805 rs62078303 chr17:80085210 A/G cg09264619 chr17:80180166 NA 0.36 6.08 0.32 3.4e-9 Life satisfaction; CRC cis rs7849270 1.000 rs10988214 chr9:131883752 A/G cg13538475 chr9:131942899 NA -0.29 -5.86 -0.31 1.13e-8 Blood metabolite ratios; CRC trans rs1005277 0.557 rs1854563 chr10:38434961 G/A cg23533926 chr12:111358616 MYL2 -0.52 -7.87 -0.4 5.24e-14 Extrinsic epigenetic age acceleration; CRC cis rs7927771 1.000 rs11039255 chr11:47495746 G/T cg18512352 chr11:47633146 NA -0.46 -9.06 -0.45 1.16e-17 Subjective well-being; CRC cis rs12477438 0.798 rs13414153 chr2:99624748 G/T cg26064155 chr2:99771622 LIPT1;TSGA10 -0.64 -8.82 -0.44 6.77e-17 Chronic sinus infection; CRC cis rs3815700 0.920 rs10426856 chr19:33096406 A/G cg02997394 chr19:33096574 ANKRD27 0.77 9.25 0.45 2.92e-18 Eosinophilic esophagitis; CRC cis rs17253792 0.915 rs79894275 chr14:56180285 C/T cg01858014 chr14:56050164 KTN1 -0.81 -6.11 -0.32 2.87e-9 Putamen volume; CRC cis rs6459804 1.000 rs58278053 chr7:157512934 A/T cg15733309 chr7:157513707 PTPRN2 0.3 5.71 0.3 2.53e-8 Bipolar disorder and schizophrenia; CRC cis rs501120 0.584 rs61857460 chr10:44688877 A/C cg09554077 chr10:44749378 NA 0.68 7.29 0.37 2.38e-12 Coronary artery disease;Coronary heart disease; CRC cis rs11711311 1.000 rs9865965 chr3:113450495 C/T cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.52 -7.0 -0.36 1.47e-11 IgG glycosylation; CRC cis rs9399137 0.507 rs4451150 chr6:135279063 T/G cg24558204 chr6:135376177 HBS1L 0.61 8.94 0.44 2.82e-17 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; CRC cis rs9513627 0.573 rs4771336 chr13:100210610 T/G cg02509730 chr13:100310205 CLYBL 0.4 5.65 0.3 3.5e-8 Obesity-related traits; CRC cis rs727505 1.000 rs7791430 chr7:124429953 G/T cg23710748 chr7:124431027 NA -0.81 -14.45 -0.62 5.5e-37 Lewy body disease; CRC cis rs4824093 0.610 rs7410773 chr22:50313727 A/G cg22709217 chr22:50311962 ALG12;CRELD2 -0.96 -9.24 -0.45 3.06e-18 Amyotrophic lateral sclerosis (sporadic); CRC trans rs1161463 0.834 rs1161471 chr13:29424482 T/C cg16311697 chr3:124249497 KALRN -0.44 -6.04 -0.32 4.27e-9 Attention deficit hyperactivity disorder symptoms (maternal expressed emotions interaction); CRC cis rs6557786 0.636 rs17052934 chr8:24840319 A/C cg02106941 chr8:24772137 NEFM -0.29 -6.06 -0.32 3.79e-9 Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 2 peripheral neuropathy); CRC cis rs13064411 0.696 rs6783965 chr3:113198722 C/T cg18753928 chr3:113234510 CCDC52 -0.67 -10.55 -0.5 1.31e-22 Response to simvastatin treatment (PCSK9 protein level change); CRC cis rs4148883 0.504 rs28720150 chr4:100132790 T/G cg13256891 chr4:100009986 ADH5 -0.41 -6.12 -0.32 2.64e-9 Alcohol dependence; CRC cis rs6921919 0.697 rs12180820 chr6:28316478 A/G cg21251018 chr6:28226885 NKAPL -0.47 -7.59 -0.39 3.24e-13 Autism spectrum disorder or schizophrenia; CRC cis rs7927771 0.965 rs12787112 chr11:47687147 A/G cg05585544 chr11:47624801 NA -0.6 -10.86 -0.51 1.11e-23 Subjective well-being; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg25161386 chr17:27621177 NUFIP2 0.52 6.69 0.35 9.56e-11 Thyroid stimulating hormone; CRC cis rs2836974 0.897 rs35064900 chr21:40555492 A/G cg11644478 chr21:40555479 PSMG1 0.84 13.39 0.59 6.15e-33 Cognitive function; CRC cis rs12922317 0.538 rs446289 chr16:12070486 T/G cg09319797 chr16:12061715 TNFRSF17 -0.34 -5.7 -0.3 2.67e-8 Schizophrenia; CRC cis rs6502050 0.835 rs35070385 chr17:80128447 G/A cg25804541 chr17:80189381 SLC16A3 -0.3 -5.84 -0.31 1.23e-8 Life satisfaction; CRC cis rs798554 1.000 rs798550 chr7:2760609 A/G cg04166393 chr7:2884313 GNA12 0.47 6.6 0.34 1.6e-10 Height; CRC cis rs2880765 0.545 rs17553734 chr15:86013059 C/G cg10818794 chr15:86012489 AKAP13 0.49 7.63 0.39 2.63e-13 Coronary artery disease; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg25373372 chr6:82462656 FAM46A -0.4 -6.27 -0.33 1.15e-9 Liver disease severity in Alagille syndrome; CRC cis rs10208940 0.920 rs6751531 chr2:68794528 G/T cg12452813 chr2:68675892 NA 0.47 5.95 0.31 6.88e-9 Urate levels in lean individuals; CRC cis rs11628318 0.853 rs6575925 chr14:103034507 C/T cg12046867 chr14:103022105 NA -0.81 -11.48 -0.53 7.02e-26 Platelet count; CRC trans rs7618501 0.602 rs9311446 chr3:50092226 G/A cg21659725 chr3:3221576 CRBN -0.6 -9.47 -0.46 5.62e-19 Intelligence (multi-trait analysis); CRC trans rs7395662 0.611 rs4882089 chr11:48515612 A/T cg03929089 chr4:120376271 NA -0.46 -6.52 -0.34 2.59e-10 HDL cholesterol; CRC cis rs8060686 0.641 rs73612690 chr16:68153200 G/A cg08314208 chr16:67682810 RLTPR -0.49 -5.88 -0.31 1.01e-8 HDL cholesterol;Metabolic syndrome; CRC cis rs769267 0.930 rs6909 chr19:19619542 A/G cg01262667 chr19:19385393 TM6SF2 0.36 5.96 0.31 6.35e-9 Tonsillectomy; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg23501767 chr5:133340570 VDAC1 0.4 5.96 0.31 6.56e-9 Intelligence (multi-trait analysis); CRC cis rs2836950 0.565 rs4816617 chr21:40540690 T/C cg17971929 chr21:40555470 PSMG1 -0.59 -8.68 -0.43 1.84e-16 Menarche (age at onset); CRC cis rs3741151 0.687 rs56857598 chr11:73234173 G/A cg17517138 chr11:73019481 ARHGEF17 0.98 8.0 0.4 2.12e-14 GIP levels in response to oral glucose tolerance test (120 minutes); CRC cis rs801193 1.000 rs7785213 chr7:66138978 A/C cg00343986 chr7:65444356 GUSB -0.5 -7.44 -0.38 8.98e-13 Aortic root size; CRC cis rs9303401 0.659 rs56162835 chr17:56687315 A/G cg02118635 chr17:56770003 RAD51C;TEX14 0.79 9.75 0.47 6.88e-20 Cognitive test performance; CRC cis rs7998202 0.667 rs282568 chr13:113371938 A/G cg02820901 chr13:113351484 ATP11A 0.51 5.64 0.3 3.73e-8 Glycated hemoglobin levels; CRC cis rs11190604 1.000 rs2495751 chr10:102327260 A/G cg07080220 chr10:102295463 HIF1AN 0.45 5.76 0.3 1.95e-8 Palmitoleic acid (16:1n-7) levels; CRC trans rs6951245 0.935 rs79067319 chr7:1065548 C/T cg13565492 chr6:43139072 SRF -0.7 -7.18 -0.37 4.76e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs4819052 0.851 rs2877018 chr21:46658306 G/A cg11663144 chr21:46675770 NA -0.83 -14.12 -0.61 9.88e-36 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs1448094 0.512 rs7960130 chr12:86243191 T/C cg18827107 chr12:86230957 RASSF9 -0.45 -7.42 -0.38 9.97e-13 Major depressive disorder; CRC cis rs11249608 0.590 rs36051170 chr5:178447971 T/C cg01312482 chr5:178451176 ZNF879 -0.36 -5.96 -0.31 6.61e-9 Pubertal anthropometrics; CRC cis rs6921919 0.638 rs9468344 chr6:28309569 A/C cg15845792 chr6:28175446 NA 0.48 6.47 0.34 3.64e-10 Autism spectrum disorder or schizophrenia; CRC cis rs9346649 0.616 rs7740995 chr6:168492221 G/A cg02770688 chr6:168491649 NA 0.6 8.57 0.43 3.98e-16 Venous thromboembolism adjusted for sickle cell variant rs77121243-T; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg17776353 chr10:88516420 BMPR1A 0.41 6.15 0.32 2.25e-9 Intelligence (multi-trait analysis); CRC cis rs11997175 0.624 rs12677772 chr8:33772521 T/C ch.8.33884649F chr8:33765107 NA 0.46 6.55 0.34 2.16e-10 Body mass index; CRC cis rs7647973 0.580 rs11716334 chr3:49230096 G/A cg07636037 chr3:49044803 WDR6 0.81 12.63 0.57 4.21e-30 Menarche (age at onset); CRC trans rs7248779 0.532 rs10153475 chr19:2413961 G/C cg25835954 chr13:50160062 RCBTB1 0.54 8.04 0.41 1.64e-14 Cortisol levels (saliva); CRC cis rs9309711 0.623 rs7569694 chr2:3483390 T/G cg10845886 chr2:3471009 TTC15 -0.4 -6.29 -0.33 9.97e-10 Neurofibrillary tangles; CRC cis rs2197308 0.703 rs10880251 chr12:37903297 G/A cg26384229 chr12:38710491 ALG10B 0.67 8.82 0.44 6.9e-17 Morning vs. evening chronotype; CRC cis rs2859741 0.608 rs480411 chr1:37476077 T/C cg09363841 chr1:37513479 NA -0.54 -9.23 -0.45 3.46e-18 Forced expiratory volume in 1 second (environmental tobacco smoke interaction); CRC cis rs9811920 0.809 rs1384062 chr3:99597928 A/C cg07805332 chr3:99536008 MIR548G;C3orf26 -0.39 -6.08 -0.32 3.35e-9 Axial length; CRC cis rs2742417 1.000 rs2742369 chr3:45754487 C/A cg04837898 chr3:45731254 SACM1L -0.36 -5.92 -0.31 7.95e-9 Response to anti-depressant treatment in major depressive disorder; CRC cis rs294883 0.739 rs9456390 chr6:159732797 G/C cg14500486 chr6:159655392 FNDC1 -0.36 -6.16 -0.32 2.11e-9 Coronary artery disease; CRC cis rs4663866 0.901 rs74877878 chr2:239198565 C/T cg16914508 chr2:239161102 PER2 0.74 7.45 0.38 8.17e-13 Irritable bowel syndrome; CRC cis rs477895 0.653 rs7939784 chr11:63910153 C/T cg04317338 chr11:64019027 PLCB3 0.6 7.28 0.37 2.53e-12 Mean platelet volume; CRC cis rs7223966 1.000 rs9908044 chr17:61747032 A/C cg23903597 chr17:61704154 MAP3K3 -0.43 -5.89 -0.31 9.43e-9 Hip circumference adjusted for BMI;Body mass index; CRC cis rs2996428 0.561 rs16824192 chr1:3748605 G/A cg22529645 chr1:3704559 LRRC47 0.43 5.78 0.3 1.73e-8 Red cell distribution width; CRC cis rs1215050 0.791 rs6838628 chr4:98809574 A/G cg05340658 chr4:99064831 C4orf37 0.44 6.6 0.34 1.63e-10 Waist-to-hip ratio adjusted for body mass index; CRC trans rs875971 0.660 rs2191268 chr7:66110224 C/T cg13471352 chr2:39944470 TMEM178 0.36 6.21 0.32 1.6e-9 Aortic root size; CRC cis rs12594515 1.000 rs8039974 chr15:45986665 A/G cg22117107 chr15:45993392 NA -0.44 -8.89 -0.44 4.14e-17 Waist circumference;Weight; CRC cis rs10504229 0.906 rs67389108 chr8:58193718 G/A cg01721255 chr8:58191610 C8orf71 0.45 5.86 0.31 1.11e-8 Developmental language disorder (linguistic errors); CRC cis rs9611565 0.608 rs202652 chr22:41838792 A/G cg03806693 chr22:41940476 POLR3H 0.96 12.91 0.58 3.84e-31 Vitiligo; CRC cis rs2882667 0.898 rs6863347 chr5:138361135 C/T cg09476006 chr5:138032270 NA 0.44 6.84 0.35 3.95e-11 Age-related hearing impairment (SNP x SNP interaction); CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg07094533 chr2:233415452 TIGD1;EIF4E2 0.46 6.32 0.33 8.57e-10 Anxiety disorder; CRC cis rs7216064 1.000 rs12451721 chr17:65939075 G/A cg12091567 chr17:66097778 LOC651250 -0.67 -7.64 -0.39 2.44e-13 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CRC trans rs561341 0.714 rs75861674 chr17:30304317 A/G cg27661571 chr11:113659931 NA -0.76 -9.48 -0.46 5.31e-19 Hip circumference adjusted for BMI; CRC cis rs6433857 0.536 rs1971135 chr2:181351508 G/A cg23363182 chr2:181467187 NA -0.55 -8.24 -0.41 4.23e-15 Body mass index; CRC cis rs17253792 0.545 rs35466279 chr14:56017022 C/T cg01858014 chr14:56050164 KTN1 -0.86 -6.64 -0.34 1.27e-10 Putamen volume; CRC cis rs561341 0.941 rs550213 chr17:30317518 C/G cg12193833 chr17:30244370 NA -0.63 -8.06 -0.41 1.39e-14 Hip circumference adjusted for BMI; CRC cis rs17767392 0.958 rs12433040 chr14:72030555 G/A cg13720639 chr14:72061746 SIPA1L1 0.56 6.88 0.35 3.04e-11 Mitral valve prolapse; CRC cis rs1862618 0.529 rs978406 chr5:56259808 A/T cg24531977 chr5:56204891 C5orf35 0.91 13.13 0.59 5.95e-32 Initial pursuit acceleration; CRC cis rs7605827 0.930 rs2003592 chr2:15552153 C/T cg19274914 chr2:15703543 NA 0.39 5.87 0.31 1.06e-8 Educational attainment (years of education); CRC trans rs9585327 0.584 rs4772260 chr13:100645723 A/G cg01125814 chr2:71559310 ZNF638 0.39 6.01 0.31 4.83e-9 Myopia; CRC cis rs375066 0.623 rs2356438 chr19:44353083 G/A cg19542119 chr19:44331823 ZNF283 0.4 5.61 0.3 4.24e-8 Breast cancer; CRC trans rs330048 0.545 rs11774353 chr8:9153127 C/T cg06636001 chr8:8085503 FLJ10661 0.46 6.01 0.31 4.95e-9 Systemic lupus erythematosus; CRC cis rs4700695 0.925 rs381549 chr5:65383371 A/G cg21114390 chr5:65439923 SFRS12 -0.62 -6.72 -0.35 8.15e-11 Facial morphology (factor 19); CRC cis rs704795 0.836 rs1647281 chr2:27612938 G/C cg17158414 chr2:27665306 KRTCAP3 -0.28 -6.01 -0.31 4.88e-9 Menopause (age at onset); CRC cis rs853679 0.517 rs9357066 chr6:28129831 T/C cg15786705 chr6:28176104 NA 0.78 9.83 0.48 3.57e-20 Depression; CRC cis rs7927771 0.524 rs7936948 chr11:47704200 T/G cg20307385 chr11:47447363 PSMC3 0.46 6.7 0.35 8.98e-11 Subjective well-being; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg21512275 chr2:157198069 NA 0.49 7.03 0.36 1.21e-11 Response to antipsychotic treatment; CRC cis rs9807989 0.507 rs10200952 chr2:103027651 A/C cg03938978 chr2:103052716 IL18RAP 0.59 10.13 0.49 3.5e-21 Asthma; CRC cis rs10486722 0.624 rs2330259 chr7:41762712 A/G cg22138096 chr7:41772439 LOC285954 -0.39 -5.87 -0.31 1.08e-8 Pit-and-Fissure caries; CRC cis rs4766646 0.619 rs9645838 chr12:110291572 A/G cg01252219 chr12:110302105 GLTP 0.42 6.34 0.33 7.58e-10 Metabolite levels (MHPG); CRC cis rs12477438 0.520 rs6717729 chr2:99756941 T/C cg26064155 chr2:99771622 LIPT1;TSGA10 0.85 15.31 0.65 2.46e-40 Chronic sinus infection; CRC cis rs6089829 1.000 rs62207535 chr20:61669187 A/G cg08564027 chr20:61660810 NA 0.79 13.3 0.59 1.36e-32 Prostate cancer (SNP x SNP interaction); CRC cis rs9914988 0.943 rs9894335 chr17:27138483 C/A cg12682573 chr17:27188876 MIR451;MIR144 0.6 8.33 0.42 2.25e-15 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs9457247 0.934 rs2345571 chr6:167403400 T/G cg23791538 chr6:167370224 RNASET2 -0.38 -5.94 -0.31 7.32e-9 Crohn's disease; CRC cis rs13064411 0.696 rs35860985 chr3:113209828 C/T cg10517650 chr3:113235015 CCDC52 -0.41 -7.18 -0.37 4.55e-12 Response to simvastatin treatment (PCSK9 protein level change); CRC cis rs13191362 1.000 rs35383933 chr6:163002869 G/A cg21926612 chr6:163149169 PACRG;PARK2 0.8 11.25 0.53 4.59e-25 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs9902453 0.904 rs9900112 chr17:28282910 T/A cg26525008 chr17:28256777 EFCAB5;SSH2 0.68 11.2 0.53 6.89e-25 Coffee consumption (cups per day); CRC cis rs6674176 0.660 rs6801 chr1:44396646 C/G cg12908607 chr1:44402522 ARTN 0.61 11.32 0.53 2.56e-25 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Cognitive ability; CRC cis rs992157 0.804 rs7559525 chr2:219150307 A/G cg04880052 chr2:219191631 PNKD -0.43 -6.8 -0.35 4.82e-11 Colorectal cancer; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg09634226 chr8:52811768 PCMTD1 0.41 6.01 0.31 5.04e-9 Intelligence (multi-trait analysis); CRC cis rs7726839 0.540 rs72703087 chr5:598029 C/T cg09021430 chr5:549028 NA -0.73 -8.33 -0.42 2.19e-15 Obesity-related traits; CRC cis rs2836974 0.590 rs11911822 chr21:40607843 C/T cg11644478 chr21:40555479 PSMG1 -0.71 -11.77 -0.54 6.4e-27 Cognitive function; CRC cis rs9549328 0.670 rs35992827 chr13:113616752 G/A cg24588162 chr13:113633484 MCF2L 0.33 5.99 0.31 5.44e-9 Systolic blood pressure; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg03007208 chr19:36266554 SNX26 0.39 6.02 0.31 4.72e-9 Intelligence (multi-trait analysis); CRC cis rs514406 0.825 rs3863643 chr1:53224577 C/T cg25767906 chr1:53392781 SCP2 0.45 7.12 0.37 6.95e-12 Monocyte count; CRC cis rs798554 0.757 rs1182177 chr7:2874540 C/T cg14895029 chr7:2775587 GNA12 -0.42 -5.97 -0.31 6.03e-9 Height; CRC cis rs7647973 0.580 rs12637576 chr3:49237334 C/T cg20833759 chr3:49053208 WDR6;DALRD3 0.41 6.71 0.35 8.54e-11 Menarche (age at onset); CRC cis rs7829975 0.533 rs1039917 chr8:8718850 C/T cg06636001 chr8:8085503 FLJ10661 0.55 8.28 0.42 3.17e-15 Mood instability; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg04729070 chr8:67837953 SNHG6 0.44 6.09 0.32 3.13e-9 Response to antipsychotic treatment; CRC cis rs1568889 1.000 rs6484346 chr11:28040767 C/A cg06544937 chr11:28130018 METT5D1;KIF18A 0.81 11.58 0.54 3.12e-26 Bipolar disorder; CRC cis rs68170813 0.559 rs76859341 chr7:107070146 C/G cg02696742 chr7:106810147 HBP1 -0.51 -5.65 -0.3 3.48e-8 Coronary artery disease; CRC cis rs2380220 0.541 rs72928277 chr6:96079745 G/T cg07718321 chr6:96025334 MANEA -0.58 -7.22 -0.37 3.52e-12 Behavioural disinhibition (generation interaction); CRC cis rs9811920 0.609 rs793467 chr3:99539664 A/G cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G 0.47 6.29 0.33 1e-9 Axial length; CRC trans rs8005150 0.737 rs4418995 chr14:88468480 G/A cg25527770 chr19:1444892 NA -0.56 -6.21 -0.32 1.64e-9 Hepatitis B; CRC cis rs9311676 0.656 rs55964615 chr3:58389120 A/T cg06643156 chr3:58380774 PXK 0.41 6.22 0.32 1.55e-9 Systemic lupus erythematosus; CRC cis rs12541635 0.701 rs2029878 chr8:107025283 A/G cg10147462 chr8:107024639 NA 0.52 9.25 0.45 2.99e-18 Age of smoking initiation; CRC cis rs9522267 0.737 rs9522285 chr13:112230701 C/T cg10483660 chr13:112241077 NA -0.4 -7.1 -0.36 7.94e-12 Hepatitis; CRC cis rs11608355 0.515 rs4766476 chr12:109934700 A/G cg05360138 chr12:110035743 NA 0.77 8.64 0.43 2.48e-16 Neuroticism; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg03482004 chr22:38349721 POLR2F;C22orf23 0.4 6.4 0.33 5.44e-10 Intelligence (multi-trait analysis); CRC cis rs738322 0.967 rs133017 chr22:38572637 A/C cg17652424 chr22:38574118 PLA2G6 -0.22 -6.86 -0.35 3.41e-11 Cutaneous nevi; CRC cis rs9611519 0.780 rs2235850 chr22:41657626 C/T cg06634786 chr22:41940651 POLR3H -0.45 -6.08 -0.32 3.26e-9 Neuroticism; CRC cis rs9611565 0.512 rs8141103 chr22:42136930 T/C cg06634786 chr22:41940651 POLR3H 0.68 7.6 0.39 3.04e-13 Vitiligo; CRC trans rs1455244 0.700 rs7229302 chr18:11508904 G/T cg01139627 chr1:94344929 DNTTIP2 0.4 6.03 0.32 4.42e-9 Schizophrenia; CRC cis rs919433 0.927 rs7592748 chr2:198170688 G/A cg03934865 chr2:198174659 NA -0.47 -7.25 -0.37 2.96e-12 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC cis rs11252926 0.897 rs7092330 chr10:583771 G/C cg18196295 chr10:418757 DIP2C -0.55 -8.06 -0.41 1.43e-14 Psychosis in Alzheimer's disease; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg25448812 chr11:46402210 MDK 0.38 6.09 0.32 3.12e-9 Liver disease severity in Alagille syndrome; CRC cis rs1552244 0.882 rs13063929 chr3:10010308 T/C cg08888203 chr3:10149979 C3orf24 0.65 8.66 0.43 2.14e-16 Alzheimer's disease; CRC cis rs13272623 0.502 rs268594 chr8:71513130 C/T cg23757474 chr8:71581111 LACTB2;XKR9 0.46 6.41 0.33 5.07e-10 IgG glycosylation; CRC cis rs832540 0.898 rs702680 chr5:56220382 T/C cg12311346 chr5:56204834 C5orf35 -0.53 -8.13 -0.41 9.03e-15 Coronary artery disease; CRC cis rs9818758 0.556 rs116432667 chr3:48947589 C/T cg00383909 chr3:49044727 WDR6 1.33 12.69 0.57 2.61e-30 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; CRC cis rs2070488 0.965 rs35091896 chr3:38443320 G/A cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.93 17.23 0.69 7.2e-48 Electrocardiographic conduction measures; CRC cis rs910316 1.000 rs2268617 chr14:75608728 G/A cg03030879 chr14:75389066 RPS6KL1 -0.48 -7.52 -0.38 5.19e-13 Height; CRC cis rs826838 0.967 rs11169142 chr12:39085773 A/T cg13010199 chr12:38710504 ALG10B -0.4 -6.03 -0.32 4.35e-9 Heart rate; CRC cis rs10752881 1.000 rs10752887 chr1:182990834 T/C ch.1.3577855R chr1:183094577 LAMC1 0.86 15.17 0.64 8.93e-40 Colorectal cancer; CRC trans rs57221529 0.563 rs4957057 chr5:569230 C/G cg25482853 chr8:67687455 SGK3 0.99 12.23 0.56 1.28e-28 Lung disease severity in cystic fibrosis; CRC cis rs1499614 0.803 rs1922723 chr7:66175063 C/T cg12463550 chr7:65579703 CRCP 0.64 5.79 0.3 1.66e-8 Gout; CRC cis rs853679 0.517 rs9393894 chr6:28112562 A/G cg21251018 chr6:28226885 NKAPL 0.48 6.17 0.32 2.02e-9 Depression; CRC cis rs9462027 0.651 rs9469884 chr6:34758703 A/T cg07306190 chr6:34760872 UHRF1BP1 -0.35 -6.24 -0.33 1.31e-9 Systemic lupus erythematosus; CRC cis rs2231884 0.697 rs11227332 chr11:65623739 A/G cg26695010 chr11:65641043 EFEMP2 -0.58 -6.37 -0.33 6.19e-10 Inflammatory bowel disease; CRC cis rs2033908 0.620 rs10765993 chr11:12849185 C/G cg25843174 chr11:12811716 TEAD1 -0.43 -7.58 -0.39 3.66e-13 Sitting height ratio; CRC trans rs35110281 0.667 rs2155722 chr21:45096206 A/G cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO -0.4 -6.4 -0.33 5.32e-10 Mean corpuscular volume; CRC cis rs751837 0.591 rs34407983 chr14:103429786 T/C cg10087771 chr14:103399429 CDC42BPB 0.67 6.37 0.33 6.45e-10 Large B-cell lymphoma; CRC cis rs763121 0.853 rs8142098 chr22:39058757 T/G cg06022373 chr22:39101656 GTPBP1 0.79 12.53 0.57 1.01e-29 Menopause (age at onset); CRC cis rs270601 0.739 rs1979981 chr5:131601720 G/A cg18758796 chr5:131593413 PDLIM4 0.48 8.82 0.44 7.04e-17 Acylcarnitine levels; CRC cis rs35146811 0.735 rs1727133 chr7:99812870 C/T cg13334819 chr7:99746414 C7orf59 0.51 6.71 0.35 8.67e-11 Coronary artery disease; CRC cis rs6496667 0.779 rs113088230 chr15:90888489 T/C cg04176472 chr15:90893244 GABARAPL3 0.58 6.84 0.35 3.82e-11 Rheumatoid arthritis; CRC trans rs61931739 0.500 rs11053166 chr12:34385898 A/C cg26384229 chr12:38710491 ALG10B -0.67 -8.99 -0.44 1.98e-17 Morning vs. evening chronotype; CRC cis rs2257205 0.667 rs6503876 chr17:56814988 G/C cg25885038 chr17:56607967 SEPT4 -0.53 -5.82 -0.31 1.4e-8 Pancreatic cancer; CRC cis rs7772486 0.597 rs6912351 chr6:146264071 T/C cg23711669 chr6:146136114 FBXO30 -0.65 -9.69 -0.47 1.06e-19 Lobe attachment (rater-scored or self-reported); CRC cis rs938554 0.784 rs11726102 chr4:9951664 T/C cg00071950 chr4:10020882 SLC2A9 -0.44 -5.91 -0.31 8.72e-9 Blood metabolite levels; CRC cis rs3733585 0.699 rs4473653 chr4:9971058 A/G cg11266682 chr4:10021025 SLC2A9 -0.46 -9.17 -0.45 5.15e-18 Cleft plate (environmental tobacco smoke interaction); CRC cis rs11764590 0.715 rs9969125 chr7:2088460 C/T cg02825527 chr7:2087843 MAD1L1 -0.49 -5.93 -0.31 7.7e-9 Neuroticism; CRC cis rs5753618 0.509 rs4820951 chr22:31586248 G/A cg22777020 chr22:31556080 RNF185 -0.53 -6.2 -0.32 1.72e-9 Colorectal cancer; CRC cis rs7309 0.935 rs6432674 chr2:162025322 G/T cg22496339 chr2:162101262 NA 0.78 13.21 0.59 2.87e-32 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Educational attainment; CRC cis rs561341 1.000 rs8064843 chr17:30245744 A/G cg23018236 chr17:30244563 NA -0.47 -6.64 -0.34 1.28e-10 Hip circumference adjusted for BMI; CRC cis rs734999 0.588 rs876938 chr1:2523212 G/C cg18854424 chr1:2615690 NA 0.4 7.65 0.39 2.28e-13 Ulcerative colitis; CRC cis rs4664293 0.833 rs3764969 chr2:160620848 G/A cg08347373 chr2:160653686 CD302 -0.44 -6.98 -0.36 1.61e-11 Monocyte percentage of white cells; CRC cis rs7772486 0.875 rs1331640 chr6:146427250 G/A cg13319975 chr6:146136371 FBXO30 -0.41 -6.24 -0.33 1.37e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs4713118 0.869 rs10214440 chr6:27702440 A/C cg20933634 chr6:27740509 NA 0.57 8.26 0.41 3.55e-15 Parkinson's disease; CRC cis rs6456156 1.000 rs6456156 chr6:167522300 T/C cg07741184 chr6:167504864 NA 0.37 6.41 0.33 5.04e-10 Primary biliary cholangitis; CRC cis rs896854 0.625 rs7823886 chr8:95986459 A/T cg23172400 chr8:95962367 TP53INP1 -0.48 -8.02 -0.4 1.82e-14 Type 2 diabetes; CRC cis rs9649465 1.000 rs10215473 chr7:123380681 C/G cg03229431 chr7:123269106 ASB15 -0.36 -5.67 -0.3 3.21e-8 Migraine; CRC cis rs66573146 1.000 rs6852613 chr4:7035637 G/A cg00086871 chr4:6988644 TBC1D14 0.88 6.83 0.35 4.07e-11 Granulocyte percentage of myeloid white cells; CRC cis rs2153535 0.580 rs1414346 chr6:8471574 A/G cg07606381 chr6:8435919 SLC35B3 0.67 10.7 0.51 4.01e-23 Motion sickness; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg16857335 chr19:47633940 SAE1 0.44 6.07 0.32 3.53e-9 Anxiety disorder; CRC cis rs4638749 1.000 rs1466213 chr2:108856607 G/A cg25838818 chr2:108905173 SULT1C2 -0.38 -6.16 -0.32 2.15e-9 Blood pressure; CRC cis rs10927875 0.526 rs35340817 chr1:16178917 T/C cg21385522 chr1:16154831 NA -0.82 -9.93 -0.48 1.72e-20 Dilated cardiomyopathy; CRC cis rs9341808 0.727 rs9352809 chr6:80999316 C/T cg08355045 chr6:80787529 NA 0.35 5.77 0.3 1.87e-8 Sitting height ratio; CRC cis rs7713065 0.531 rs2522051 chr5:131797578 C/T cg18301423 chr5:131593218 PDLIM4 0.32 5.94 0.31 7.34e-9 Lung function (FEV1/FVC); CRC cis rs13256369 1.000 rs13271966 chr8:8575472 T/C cg18904891 chr8:8559673 CLDN23 0.52 7.17 0.37 5.12e-12 Obesity-related traits; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg26074148 chr5:71615866 PTCD2;MRPS27 0.47 6.02 0.31 4.59e-9 Thyroid stimulating hormone; CRC cis rs13108904 0.870 rs12499546 chr4:1255194 C/T cg05665937 chr4:1216051 CTBP1 0.43 6.44 0.33 4.34e-10 Obesity-related traits; CRC cis rs9648716 1.000 rs6944385 chr7:140614387 A/T cg10747023 chr7:140774559 NA 0.47 6.1 0.32 2.98e-9 Type 2 diabetes; CRC cis rs34172651 0.517 rs2303084 chr16:24834581 G/C cg06028605 chr16:24865363 SLC5A11 0.56 8.61 0.43 2.99e-16 Intelligence (multi-trait analysis); CRC trans rs12599106 0.818 rs17723574 chr16:34602945 C/G cg03395511 chr6:291903 DUSP22 -0.48 -6.74 -0.35 7.02e-11 Menopause (age at onset); CRC cis rs782590 0.967 rs1084522 chr2:55843294 A/G cg18811423 chr2:55921094 PNPT1 0.81 14.79 0.63 2.69e-38 Metabolic syndrome; CRC cis rs847577 0.588 rs12666406 chr7:97790991 G/A cg00277769 chr7:97922759 BAIAP2L1 -0.4 -6.68 -0.35 1.02e-10 Breast cancer; CRC cis rs11098499 0.530 rs114866537 chr4:120258608 A/T cg09307838 chr4:120376055 NA 0.6 9.53 0.47 3.52e-19 Corneal astigmatism; CRC cis rs10504229 0.774 rs72650880 chr8:58164727 C/T cg24829409 chr8:58192753 C8orf71 -0.68 -8.88 -0.44 4.29e-17 Developmental language disorder (linguistic errors); CRC cis rs12477438 1.000 rs12053372 chr2:99810055 C/T cg26064155 chr2:99771622 LIPT1;TSGA10 -0.75 -9.15 -0.45 6.09e-18 Chronic sinus infection; CRC cis rs853679 0.517 rs2281588 chr6:28072602 G/A cg15845792 chr6:28175446 NA 0.98 13.03 0.58 1.45e-31 Depression; CRC cis rs6951245 1.000 rs77083167 chr7:1071823 C/T cg22907277 chr7:1156413 C7orf50 0.71 7.39 0.38 1.26e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs539514 0.690 rs480929 chr13:76312773 G/A cg04757411 chr13:76259545 LMO7 -0.36 -6.05 -0.32 4.04e-9 Type 1 diabetes; CRC cis rs4819052 0.851 rs2838849 chr21:46671027 A/G cg19498844 chr21:46707878 POFUT2;LOC642852 0.75 10.82 0.51 1.49e-23 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg08234897 chr7:151217114 RHEB 0.45 6.01 0.31 4.96e-9 Anxiety disorder; CRC cis rs4332037 0.805 rs10278591 chr7:1921362 A/G cg25834613 chr7:1915315 MAD1L1 0.52 8.82 0.44 6.9e-17 Bipolar disorder; CRC cis rs801193 1.000 rs10274773 chr7:66133578 G/A cg11764359 chr7:65958608 NA -0.54 -8.29 -0.42 2.97e-15 Aortic root size; CRC cis rs10208940 0.920 rs13400463 chr2:68723912 G/A cg12452813 chr2:68675892 NA 0.51 6.35 0.33 7.33e-10 Urate levels in lean individuals; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg18122411 chr2:122513043 TSN 0.39 6.07 0.32 3.55e-9 Liver disease severity in Alagille syndrome; CRC cis rs11190604 1.000 rs7477246 chr10:102261538 C/T cg16342193 chr10:102329863 NA -0.35 -5.88 -0.31 1.03e-8 Palmitoleic acid (16:1n-7) levels; CRC cis rs6761276 0.525 rs12711752 chr2:113837840 C/T cg12858261 chr2:113808755 IL1F8 -0.35 -5.6 -0.3 4.51e-8 Protein quantitative trait loci; CRC cis rs4975709 0.589 rs1684967 chr5:1863055 G/C cg06654549 chr5:1875058 NA 0.39 5.78 0.3 1.75e-8 Cardiovascular disease risk factors; CRC cis rs375066 0.762 rs10424336 chr19:44392100 C/T cg12072164 chr19:44306565 LYPD5 0.39 5.8 0.3 1.57e-8 Breast cancer; CRC cis rs1451375 0.652 rs7803903 chr7:50625945 C/T cg14593290 chr7:50529359 DDC 0.59 7.9 0.4 4.2e-14 Malaria; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg09894072 chr16:68279486 PLA2G15 0.49 6.97 0.36 1.71e-11 Response to antipsychotic treatment; CRC cis rs2303745 0.589 rs11882562 chr19:17395055 C/G cg04248312 chr19:17393744 ANKLE1 0.91 14.0 0.61 2.88e-35 Systemic lupus erythematosus; CRC cis rs3796619 1.000 rs13146371 chr4:1082887 C/T cg11579758 chr4:1086637 RNF212 0.4 6.62 0.34 1.44e-10 Recombination rate (males); CRC cis rs8114671 0.562 rs6120746 chr20:33448496 A/G cg07148914 chr20:33460835 GGT7 0.43 7.07 0.36 9.39e-12 Height; CRC cis rs514406 0.679 rs12563825 chr1:53238324 G/T cg08859206 chr1:53392774 SCP2 0.63 10.17 0.49 2.65e-21 Monocyte count; CRC cis rs6938 0.534 rs4886636 chr15:75196176 G/A cg18612461 chr15:75251733 NA 0.37 5.87 0.31 1.06e-8 Breast cancer; CRC cis rs561341 0.830 rs7218801 chr17:30217778 A/G cg19193384 chr17:30244184 NA 0.47 5.76 0.3 1.97e-8 Hip circumference adjusted for BMI; CRC cis rs4654899 0.865 rs6664532 chr1:21515800 G/A cg02927042 chr1:21476669 EIF4G3 -0.49 -7.66 -0.39 2.11e-13 Superior frontal gyrus grey matter volume; CRC cis rs1129187 0.934 rs9471974 chr6:42918984 T/A cg02353165 chr6:42928485 GNMT 0.85 15.67 0.65 9.64e-42 Alzheimer's disease in APOE e4+ carriers; CRC cis rs28386778 0.863 rs58269663 chr17:61843130 G/A cg06601766 chr17:61851465 DDX42;CCDC47 0.45 6.1 0.32 3.06e-9 Prudent dietary pattern; CRC cis rs10504229 0.596 rs7004566 chr8:58115602 G/C cg04204079 chr8:58130323 NA -0.45 -5.78 -0.3 1.71e-8 Developmental language disorder (linguistic errors); CRC cis rs7666738 0.753 rs35146453 chr4:98902278 A/G cg05340658 chr4:99064831 C4orf37 0.59 8.95 0.44 2.64e-17 Colonoscopy-negative controls vs population controls; CRC cis rs6534441 0.727 rs77274206 chr4:125462188 G/C cg21609808 chr4:125404261 NA 0.41 5.76 0.3 1.95e-8 Major depressive disorder; CRC cis rs8022179 0.580 rs6575979 chr14:103841018 A/G cg12935359 chr14:103987150 CKB -0.52 -7.31 -0.37 2.03e-12 Monocyte count; CRC cis rs2949837 0.581 rs924140 chr7:45963114 C/T cg04796162 chr7:45961102 IGFBP3 0.4 7.0 0.36 1.42e-11 Sitting height ratio; CRC cis rs2281845 0.826 rs4915215 chr1:201077212 C/T cg22815214 chr1:201083145 CACNA1S -0.53 -8.7 -0.43 1.62e-16 Permanent tooth development; CRC cis rs3806843 0.576 rs246043 chr5:140330924 G/A cg19875535 chr5:140030758 IK 0.4 6.12 0.32 2.64e-9 Depressive symptoms (multi-trait analysis); CRC cis rs634534 0.561 rs613924 chr11:65769295 C/T cg26695010 chr11:65641043 EFEMP2 -0.39 -5.97 -0.31 6.06e-9 Sum eosinophil basophil counts;Eosinophil counts; CRC cis rs1862618 0.511 rs2591952 chr5:56120769 T/A cg03609598 chr5:56110824 MAP3K1 -0.85 -10.66 -0.51 5.63e-23 Initial pursuit acceleration; CRC cis rs17767392 0.958 rs12896986 chr14:71922893 T/G cg13720639 chr14:72061746 SIPA1L1 -0.56 -7.17 -0.37 5.11e-12 Mitral valve prolapse; CRC cis rs11608355 0.618 rs60819157 chr12:109795766 G/A cg19025524 chr12:109796872 NA -0.62 -10.17 -0.49 2.56e-21 Neuroticism; CRC cis rs477895 0.568 rs34838337 chr11:63870892 T/C cg19465662 chr11:63993652 NUDT22;TRPT1 0.59 7.27 0.37 2.66e-12 Mean platelet volume; CRC cis rs3751196 0.808 rs56143748 chr12:104217196 C/G cg02344784 chr12:104178138 NT5DC3 0.71 7.54 0.38 4.58e-13 Sense of smell; CRC cis rs12681287 0.547 rs11992656 chr8:87534869 T/A cg27223183 chr8:87520930 FAM82B 0.5 6.69 0.35 9.72e-11 Caudate activity during reward; CRC cis rs360798 0.532 rs189671 chr2:62959308 T/A cg17519650 chr2:63277830 OTX1 -0.41 -5.63 -0.3 3.78e-8 Coronary artery disease; CRC trans rs9858542 0.953 rs11710037 chr3:49675334 C/G cg21665057 chr3:196295764 WDR53;FBXO45 -0.69 -8.95 -0.44 2.61e-17 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs728616 0.850 rs3889823 chr10:81918362 T/C cg05935833 chr10:81318306 SFTPA2 -0.74 -8.21 -0.41 4.94e-15 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs908922 0.651 rs10888493 chr1:152503913 G/A cg23254163 chr1:152506842 NA 0.5 10.09 0.49 4.75e-21 Hair morphology; CRC cis rs2153535 0.580 rs7748455 chr6:8453625 C/T cg21535247 chr6:8435926 SLC35B3 0.52 8.0 0.4 2.14e-14 Motion sickness; CRC trans rs2797160 1.000 rs1739362 chr6:126020703 A/T cg05039488 chr6:79577232 IRAK1BP1 0.5 7.47 0.38 7.24e-13 Endometrial cancer; CRC cis rs9660180 0.839 rs12040826 chr1:1705287 A/C cg23982607 chr1:1823379 GNB1 -0.86 -15.24 -0.64 4.59e-40 Body mass index; CRC cis rs9311474 0.508 rs17052256 chr3:52593119 A/G cg18404041 chr3:52824283 ITIH1 -0.41 -8.71 -0.43 1.56e-16 Electroencephalogram traits; CRC cis rs896854 0.684 rs2340534 chr8:95992330 G/A cg16049864 chr8:95962084 TP53INP1 -0.64 -11.76 -0.54 6.7399999999999993e-27 Type 2 diabetes; CRC cis rs3008870 0.583 rs2147838 chr1:67399466 T/C cg08660285 chr1:67390436 MIER1;WDR78 1.01 12.36 0.56 4.47e-29 Lymphocyte percentage of white cells; CRC cis rs9372498 0.536 rs62422220 chr6:118923731 G/A cg10217327 chr6:118973057 C6orf204 0.53 5.94 0.31 7.14e-9 Diastolic blood pressure; CRC cis rs1865760 0.865 rs4478388 chr6:25953633 A/G cg16482183 chr6:26056742 HIST1H1C 0.55 7.99 0.4 2.25e-14 Height; CRC cis rs875971 1.000 rs1565531 chr7:65663113 T/A cg00343986 chr7:65444356 GUSB -0.45 -6.7 -0.35 8.85e-11 Aortic root size; CRC cis rs9311474 0.508 rs6786043 chr3:52604861 A/G cg11645453 chr3:52864694 ITIH4 0.35 6.3 0.33 9.46e-10 Electroencephalogram traits; CRC cis rs477895 0.838 rs35090903 chr11:64000598 C/T cg19465662 chr11:63993652 NUDT22;TRPT1 0.76 9.27 0.45 2.57e-18 Mean platelet volume; CRC cis rs10504229 0.679 rs17193048 chr8:58055392 G/A cg02725872 chr8:58115012 NA -0.57 -7.96 -0.4 2.76e-14 Developmental language disorder (linguistic errors); CRC cis rs7552404 0.727 rs61770533 chr1:76306490 C/G cg10523679 chr1:76189770 ACADM 0.73 9.51 0.46 4.24e-19 Blood metabolite levels;Acylcarnitine levels; CRC cis rs7618915 0.571 rs34954168 chr3:52612159 C/T cg05573699 chr3:52720067 GNL3;PBRM1 -0.46 -6.58 -0.34 1.81e-10 Bipolar disorder; CRC cis rs7208859 0.623 rs3752019 chr17:29151705 C/T cg01831904 chr17:28903510 LRRC37B2 -0.61 -6.4 -0.33 5.3e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs17539620 0.529 rs11753075 chr6:154875085 A/G cg20019720 chr6:154832845 CNKSR3 0.34 7.67 0.39 1.95e-13 Lipoprotein (a) levels; CRC cis rs832540 0.931 rs2662040 chr5:56246610 A/G cg12311346 chr5:56204834 C5orf35 0.53 8.13 0.41 8.65e-15 Coronary artery disease; CRC trans rs453301 0.571 rs330048 chr8:9087278 A/C cg06636001 chr8:8085503 FLJ10661 -0.57 -9.04 -0.45 1.38e-17 Joint mobility (Beighton score); CRC cis rs3820068 0.603 rs17448778 chr1:15985306 A/G cg13390004 chr1:15929781 NA 0.43 6.24 0.33 1.37e-9 Systolic blood pressure; CRC cis rs17270561 0.609 rs9379789 chr6:25745579 A/G cg16482183 chr6:26056742 HIST1H1C 0.83 10.69 0.51 4.46e-23 Iron status biomarkers; CRC cis rs1113500 0.897 rs55980437 chr1:108639498 G/A cg06207961 chr1:108661230 NA 0.39 5.75 0.3 2.07e-8 Growth-regulated protein alpha levels; CRC cis rs644799 0.896 rs4430471 chr11:95646774 G/A cg03916912 chr11:95522834 CEP57;FAM76B 0.95 17.24 0.69 6.35e-48 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs2303745 0.589 rs11086065 chr19:17395003 A/G cg27101125 chr19:17392770 ANKLE1 -0.33 -5.85 -0.31 1.19e-8 Systemic lupus erythematosus; CRC cis rs2735413 0.918 rs56397244 chr16:78081366 A/T cg04733911 chr16:78082701 NA -0.44 -7.37 -0.38 1.38e-12 Systolic blood pressure (alcohol consumption interaction); CRC cis rs7246657 0.943 rs4801759 chr19:37954985 G/A cg23950597 chr19:37808831 NA -0.54 -6.46 -0.34 3.68e-10 Coronary artery calcification; CRC cis rs427941 0.632 rs201490 chr7:101751910 C/T cg06246474 chr7:101738831 CUX1 0.44 6.73 0.35 7.61e-11 Plasma omega-3 polyunsaturated fatty acid level (eicosapentaenoic acid); CRC cis rs11098699 0.821 rs13110588 chr4:124220676 A/G cg09941581 chr4:124220074 SPATA5 -0.41 -6.2 -0.32 1.67e-9 Mosquito bite size; CRC cis rs977987 0.778 rs7203157 chr16:75417920 T/C cg03315344 chr16:75512273 CHST6 0.54 9.09 0.45 9.42e-18 Dupuytren's disease; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg25718402 chr17:7165909 CLDN7 0.5 6.75 0.35 6.89e-11 Thyroid stimulating hormone; CRC cis rs1707322 0.752 rs28550303 chr1:46188914 G/T cg03146154 chr1:46216737 IPP 0.68 9.87 0.48 2.77e-20 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs7769051 1.000 rs58832890 chr6:133127139 C/T cg07930552 chr6:133119739 C6orf192 0.73 8.8 0.44 7.83e-17 Type 2 diabetes nephropathy; CRC cis rs4481887 0.927 rs4390208 chr1:248472211 C/T cg00666640 chr1:248458726 OR2T12 0.46 8.01 0.4 1.94e-14 Common traits (Other); CRC cis rs3823572 0.564 rs1986870 chr7:133660109 A/G cg03336402 chr7:133662267 EXOC4 -0.67 -10.62 -0.51 7.59e-23 Intelligence (multi-trait analysis); CRC cis rs1707322 1.000 rs785468 chr1:46521517 G/A cg03146154 chr1:46216737 IPP -0.51 -7.1 -0.36 7.86e-12 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs7223966 0.961 rs17631394 chr17:61646000 A/G cg23090583 chr17:61904693 PSMC5;FTSJ3 -0.5 -6.15 -0.32 2.3e-9 Hip circumference adjusted for BMI;Body mass index; CRC cis rs3864277 0.510 rs31478 chr5:131423475 T/C cg11843238 chr5:131593191 PDLIM4 0.32 5.76 0.3 1.97e-8 Itch intensity from mosquito bite adjusted by bite size; CRC cis rs236352 0.576 rs9380618 chr6:36853543 A/G cg10099585 chr6:36853529 C6orf89 -0.45 -6.29 -0.33 9.94e-10 Heart rate; CRC trans rs4512344 0.509 rs2409784 chr8:11396856 G/T cg06636001 chr8:8085503 FLJ10661 -0.55 -8.27 -0.41 3.34e-15 Bone ultrasound measurement (broadband ultrasound attenuation); CRC cis rs6951245 1.000 rs78523927 chr7:1089458 T/C cg24642844 chr7:1081250 C7orf50 -0.79 -9.35 -0.46 1.4e-18 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs7725052 0.608 rs7717304 chr5:40481206 C/T cg09067459 chr5:40385259 NA 0.35 5.73 0.3 2.24e-8 Pediatric autoimmune diseases; CRC cis rs7772486 0.790 rs3924499 chr6:146232978 A/T cg13319975 chr6:146136371 FBXO30 0.42 6.41 0.33 4.97e-10 Lobe attachment (rater-scored or self-reported); CRC cis rs8077889 0.871 rs8081101 chr17:41904332 C/T cg26893861 chr17:41843967 DUSP3 0.87 12.21 0.56 1.52e-28 Triglycerides; CRC cis rs4665809 0.878 rs6720312 chr2:26364934 A/G cg26119090 chr2:26468346 HADHA;HADHB 0.67 8.01 0.4 2.06e-14 Gut microbiome composition (summer); CRC trans rs7618501 0.501 rs35275715 chr3:49959148 A/G cg21665057 chr3:196295764 WDR53;FBXO45 0.48 7.07 0.36 9.57e-12 Intelligence (multi-trait analysis); CRC cis rs6973256 0.569 rs12532950 chr7:133434286 C/T cg10665199 chr7:133106180 EXOC4 0.44 6.88 0.35 2.97e-11 Intelligence (multi-trait analysis); CRC cis rs4713118 0.621 rs9368548 chr6:28034737 A/G cg12273811 chr6:28175739 NA 0.63 8.03 0.4 1.75e-14 Parkinson's disease; CRC cis rs1552244 1.000 rs7611218 chr3:10063960 T/C cg02579736 chr3:10068473 FANCD2;CIDECP 0.95 12.63 0.57 4.38e-30 Alzheimer's disease; CRC cis rs798554 0.959 rs798528 chr7:2772431 A/C cg04166393 chr7:2884313 GNA12 0.51 6.88 0.35 3.01e-11 Height; CRC cis rs2737618 0.698 rs2737681 chr1:200091864 C/T cg21825944 chr1:200113062 NR5A2 -0.52 -7.39 -0.38 1.22e-12 Uric acid levels; CRC cis rs4853012 0.887 rs77148265 chr2:74339519 C/T cg19729930 chr2:74357872 NA 0.67 10.13 0.49 3.54e-21 Gestational age at birth (maternal effect); CRC cis rs6879260 1.000 rs888922 chr5:179731635 C/G cg23221052 chr5:179740743 GFPT2 -0.66 -10.39 -0.5 4.6e-22 Height; CRC cis rs738322 0.935 rs2413503 chr22:38568944 A/T cg03162506 chr22:38580953 NA 0.26 5.69 0.3 2.77e-8 Cutaneous nevi; CRC cis rs7772486 0.754 rs702318 chr6:146005873 G/T cg05347473 chr6:146136440 FBXO30 -0.42 -6.26 -0.33 1.22e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs7677751 0.767 rs6846502 chr4:55062090 T/C cg13615338 chr4:55094005 PDGFRA 0.41 5.89 0.31 9.78e-9 Corneal astigmatism; CRC cis rs11645898 1.000 rs11645898 chr16:72229532 A/G cg14768367 chr16:72042858 DHODH -0.58 -6.58 -0.34 1.9e-10 Blood protein levels; CRC cis rs10654220 1 rs10654220 chr12:123703422 A/AGTT cg00376283 chr12:123451042 ABCB9 0.58 6.84 0.35 3.95e-11 Platelet count; CRC cis rs9292777 0.518 rs10056760 chr5:40482599 C/T cg09067459 chr5:40385259 NA 0.39 6.4 0.33 5.36e-10 Crohn's disease;Multiple sclerosis; CRC cis rs7666738 0.830 rs9996098 chr4:98867740 T/C cg05340658 chr4:99064831 C4orf37 0.57 8.45 0.42 9.23e-16 Colonoscopy-negative controls vs population controls; CRC cis rs17376456 0.877 rs13169675 chr5:93331284 A/G cg25358565 chr5:93447407 FAM172A 1.08 10.63 0.51 7.1e-23 Diabetic retinopathy; CRC cis rs6844506 1.000 rs4862356 chr4:185220262 A/G cg18317788 chr4:185205197 NA 0.44 6.32 0.33 8.38e-10 Gestational age at birth in premature rupture of membrane-initiated deliveries (child effect); CRC cis rs4073582 0.595 rs10896104 chr11:66001869 C/T cg14036092 chr11:66035641 RAB1B 0.56 8.92 0.44 3.2e-17 Gout; CRC cis rs6062302 0.522 rs11696202 chr20:62246292 G/C cg16989086 chr20:62203971 PRIC285 0.5 6.47 0.34 3.65e-10 Glioblastoma; CRC cis rs10875746 0.951 rs58865997 chr12:48566873 G/A cg26205652 chr12:48591994 NA 0.47 5.65 0.3 3.57e-8 Longevity (90 years and older); CRC cis rs7208859 0.673 rs9891413 chr17:29208209 G/C cg01831904 chr17:28903510 LRRC37B2 -0.55 -5.77 -0.3 1.88e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs1018836 0.632 rs6988302 chr8:91477660 C/T cg16814680 chr8:91681699 NA -0.67 -10.36 -0.5 5.87e-22 Ejection fraction in Tripanosoma cruzi seropositivity; CRC cis rs1448094 0.547 rs7954472 chr12:86166258 T/C cg18827107 chr12:86230957 RASSF9 -0.39 -5.91 -0.31 8.56e-9 Major depressive disorder; CRC trans rs1005277 0.579 rs2474608 chr10:38457109 C/T cg11292332 chr7:45801988 SEPT13 -0.35 -6.17 -0.32 2e-9 Extrinsic epigenetic age acceleration; CRC trans rs208515 0.525 rs10944863 chr6:66676238 C/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.9 11.36 0.53 1.95e-25 Exhaled nitric oxide levels; CRC cis rs9323205 0.954 rs4898682 chr14:51639577 C/T cg23942311 chr14:51606299 NA -0.58 -8.02 -0.4 1.9e-14 Cancer; CRC cis rs853679 0.517 rs9380061 chr6:28132803 T/C cg21251018 chr6:28226885 NKAPL 0.48 6.17 0.32 2.02e-9 Depression; CRC cis rs875971 1.000 rs875971 chr7:65617595 A/G cg11764359 chr7:65958608 NA -0.61 -10.03 -0.48 7.82e-21 Aortic root size; CRC cis rs6860806 0.631 rs4705931 chr5:131588345 T/C cg02033258 chr5:131593261 PDLIM4 0.41 7.82 0.4 7.26e-14 Breast cancer; CRC cis rs9372498 0.536 rs9489395 chr6:118758884 T/C cg24463073 chr6:118973353 C6orf204 0.52 6.83 0.35 4.24e-11 Diastolic blood pressure; CRC cis rs59918340 0.728 rs10875467 chr8:142233396 A/C cg23750338 chr8:142222470 SLC45A4 -0.61 -11.33 -0.53 2.39e-25 Immature fraction of reticulocytes; CRC cis rs6502050 0.835 rs9646397 chr17:80083534 G/A cg22110888 chr17:80059540 CCDC57 -0.41 -6.39 -0.33 5.58e-10 Life satisfaction; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg08634762 chr5:134074437 CAMLG 0.44 6.25 0.33 1.3e-9 Anxiety disorder; CRC cis rs798554 0.797 rs798497 chr7:2795957 A/G cg19346786 chr7:2764209 NA -0.39 -6.92 -0.36 2.44e-11 Height; CRC cis rs2976388 0.609 rs2572909 chr8:143806464 C/G cg20041105 chr8:143859282 LYNX1 0.45 8.09 0.41 1.16e-14 Urinary tract infection frequency; CRC cis rs12692738 0.526 rs355856 chr2:165628977 T/A cg03182029 chr2:165697222 COBLL1 0.5 5.86 0.31 1.11e-8 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);Waist-to-hip ratio adjusted for BMI in non-smokers;Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction);Waist-to-hip ratio adjusted for body mass index; CRC cis rs7927771 0.524 rs10742814 chr11:47554337 G/A cg20307385 chr11:47447363 PSMC3 0.53 7.9 0.4 4.36e-14 Subjective well-being; CRC cis rs6942756 0.774 rs2694574 chr7:128908963 A/G cg02491457 chr7:128862824 NA 0.66 9.21 0.45 3.96e-18 White matter hyperintensity burden; CRC cis rs4867766 0.871 rs2242419 chr5:173959332 C/T cg20434911 chr5:173954559 NA 0.73 8.7 0.43 1.57e-16 Stroke; CRC cis rs873946 0.586 rs12259688 chr10:134549628 A/G cg06453172 chr10:134556979 INPP5A -0.69 -8.77 -0.44 9.65e-17 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CRC cis rs4880487 0.888 rs72760998 chr10:1251203 T/C cg03183215 chr10:1252341 ADARB2 -0.28 -5.66 -0.3 3.3e-8 Migraine; CRC cis rs9372498 0.536 rs9489447 chr6:118900846 G/A cg22561889 chr6:118971681 C6orf204 0.51 6.56 0.34 2.06e-10 Diastolic blood pressure; CRC cis rs896854 1.000 rs896854 chr8:95960511 T/C cg09323728 chr8:95962352 TP53INP1 -0.42 -6.79 -0.35 5.16e-11 Type 2 diabetes; CRC cis rs12024301 0.557 rs10494564 chr1:183654232 A/T cg11505048 chr1:183622726 RGL1;APOBEC4 0.71 6.24 0.33 1.33e-9 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs6570726 0.791 rs11155435 chr6:145938545 T/C cg05347473 chr6:146136440 FBXO30 0.38 5.7 0.3 2.72e-8 Lobe attachment (rater-scored or self-reported); CRC cis rs3617 0.532 rs9836499 chr3:52904524 G/T cg07507251 chr3:52567010 NT5DC2 -0.38 -5.75 -0.3 2.04e-8 Red blood cell count;Autism spectrum disorder or schizophrenia; CRC cis rs12476592 0.602 rs262472 chr2:63833616 G/A cg10828910 chr2:63850056 LOC388955 0.5 6.1 0.32 2.95e-9 Childhood ear infection; CRC cis rs2294693 0.945 rs10947944 chr6:41004657 T/C cg14769373 chr6:40998127 UNC5CL -0.5 -6.29 -0.33 1.01e-9 Gastric cancer;Non-cardia gastric cancer; CRC cis rs9467711 0.651 rs72832596 chr6:25962951 C/A cg16898833 chr6:26189333 HIST1H4D 0.74 6.39 0.33 5.68e-10 Autism spectrum disorder or schizophrenia; CRC cis rs929354 0.742 rs7785227 chr7:156999297 C/T cg16102536 chr7:156981717 UBE3C 0.4 6.77 0.35 5.77e-11 Body mass index; CRC cis rs568617 1.000 rs641018 chr11:65655393 G/C cg19792802 chr11:65647270 CTSW 0.5 7.55 0.38 4.23e-13 Crohn's disease; CRC cis rs11030122 0.673 rs10835596 chr11:4099666 C/T cg18678763 chr11:4115507 RRM1 -0.55 -8.67 -0.43 1.96e-16 Mean platelet volume;Platelet distribution width; CRC cis rs4891159 0.548 rs689902 chr18:74119969 C/T cg24786174 chr18:74118243 ZNF516 -0.91 -21.28 -0.76 8.56e-64 Longevity; CRC cis rs13266463 1.000 rs13266463 chr8:143403693 A/G cg16886403 chr8:143471632 TSNARE1 -0.47 -7.04 -0.36 1.13e-11 Schizophrenia; CRC cis rs8044995 0.563 rs8059585 chr16:68376811 G/A cg09835421 chr16:68378352 PRMT7 -0.77 -8.1 -0.41 1.1e-14 Schizophrenia; CRC cis rs2286885 1.000 rs741022 chr9:129252113 C/G cg15282417 chr9:129245246 FAM125B 0.44 8.25 0.41 3.85e-15 Intraocular pressure; CRC cis rs2731664 0.792 rs652242 chr5:176873010 C/G cg23176889 chr5:176863531 GRK6 -0.74 -16.13 -0.66 1.56e-43 Intelligence (multi-trait analysis); CRC cis rs8180040 1.000 rs1076394 chr3:47322781 G/A cg02527881 chr3:46936655 PTH1R 0.4 7.18 0.37 4.75e-12 Colorectal cancer; CRC trans rs13046373 0.905 rs4816372 chr21:32077414 A/T cg05999729 chr2:98369433 NA -0.4 -6.13 -0.32 2.57e-9 HDL cholesterol; CRC cis rs9549328 0.837 rs9549618 chr13:113628648 G/A cg16822035 chr13:113633379 MCF2L -0.29 -5.93 -0.31 7.57e-9 Systolic blood pressure; CRC cis rs9486715 0.838 rs6928442 chr6:96870118 A/G cg06623918 chr6:96969491 KIAA0776 1.02 20.3 0.75 5.5e-60 Headache; CRC cis rs365302 0.767 rs412690 chr6:159613544 G/A cg14500486 chr6:159655392 FNDC1 0.6 8.63 0.43 2.63e-16 Coronary heart disease; CRC cis rs1656402 1.000 rs1210070 chr2:233423788 C/G cg03852847 chr2:233439513 NA 0.45 7.71 0.39 1.54e-13 Non-small cell lung cancer (survival); CRC trans rs1005277 0.579 rs1780146 chr10:38517874 C/A cg27523141 chr10:43048294 ZNF37B 0.45 6.47 0.34 3.65e-10 Extrinsic epigenetic age acceleration; CRC cis rs6701037 0.566 rs1014555 chr1:175134249 C/T cg00321850 chr1:175162397 KIAA0040 0.45 7.54 0.38 4.47e-13 Alcohol dependence; CRC cis rs2228479 0.850 rs11640188 chr16:89807732 C/T cg19635926 chr16:89946313 TCF25 0.66 5.98 0.31 5.71e-9 Skin colour saturation; CRC cis rs10789491 1.000 rs10789491 chr1:47179310 A/G cg15501359 chr1:47185051 KIAA0494 0.76 9.15 0.45 6.19e-18 Response to hepatitis C treatment; CRC cis rs4604732 0.642 rs4472786 chr1:247636518 G/A cg02104434 chr1:247694406 LOC148824;OR2C3 0.41 6.62 0.34 1.45e-10 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CRC cis rs9534288 0.797 rs7331368 chr13:46609062 G/C cg15192986 chr13:46630673 CPB2 -0.68 -9.89 -0.48 2.31e-20 Blood protein levels; CRC cis rs10791097 0.677 rs11222359 chr11:130730648 A/G cg12179176 chr11:130786555 SNX19 0.68 11.08 0.52 1.79e-24 Autism spectrum disorder or schizophrenia;Schizophrenia; CRC cis rs6834538 1.000 rs1486864 chr4:113465766 G/T cg10021238 chr4:113569128 MIR367;LARP7 -0.46 -6.78 -0.35 5.72e-11 Free thyroxine concentration; CRC cis rs2806561 0.780 rs4655142 chr1:23333728 T/C cg19743168 chr1:23544995 NA -0.37 -5.94 -0.31 7.35e-9 Height; CRC cis rs3849570 1.000 rs6548773 chr3:81840222 C/T cg07356753 chr3:81810745 GBE1 0.72 10.9 0.52 7.75e-24 Waist circumference;Body mass index; CRC cis rs7949030 0.523 rs12223627 chr11:62368557 G/C cg22862634 chr11:62369728 EML3;MTA2 0.52 8.33 0.42 2.21e-15 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; CRC cis rs7666738 0.791 rs13146909 chr4:98934198 C/T cg05340658 chr4:99064831 C4orf37 0.6 9.35 0.46 1.41e-18 Colonoscopy-negative controls vs population controls; CRC cis rs889312 0.500 rs11960484 chr5:56109154 C/T cg24531977 chr5:56204891 C5orf35 0.45 7.0 0.36 1.47e-11 Breast cancer;Breast cancer (early onset); CRC cis rs8072100 0.713 rs2136750 chr17:45456100 A/G cg25173405 chr17:45401733 C17orf57 -0.46 -6.93 -0.36 2.26e-11 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC trans rs7859245 1.000 rs7859245 chr9:138490597 A/G cg14410503 chr7:47343076 TNS3 0.37 6.18 0.32 1.89e-9 Response to paliperidone in schizophrenia (negative Marder score); CRC cis rs6700896 0.966 rs10889570 chr1:66088084 C/G cg04111102 chr1:66153794 NA 0.33 5.92 0.31 7.88e-9 C-reactive protein;Mean corpuscular volume;Mean corpuscular hemoglobin; CRC cis rs4664308 0.618 rs62175488 chr2:160892758 T/C cg03641300 chr2:160917029 PLA2R1 -0.56 -8.46 -0.42 9.06e-16 Idiopathic membranous nephropathy; CRC cis rs3812762 0.618 rs11042072 chr11:8822032 A/G cg14711859 chr11:8959438 ASCL3 0.46 7.0 0.36 1.45e-11 Hypospadias; CRC cis rs524281 0.692 rs11227395 chr11:65829637 A/C cg14036092 chr11:66035641 RAB1B -0.44 -5.84 -0.31 1.28e-8 Electroencephalogram traits; CRC cis rs3771570 1.000 rs1056801 chr2:242292307 T/C cg21155796 chr2:242212141 HDLBP 0.65 7.01 0.36 1.37e-11 Prostate cancer; CRC cis rs116095464 0.681 rs10060016 chr5:241100 T/C cg22857025 chr5:266934 NA -1.25 -16.69 -0.68 9.69e-46 Breast cancer; CRC cis rs7246657 0.943 rs4801803 chr19:37966923 A/G cg23950597 chr19:37808831 NA 0.53 6.43 0.33 4.54e-10 Coronary artery calcification; CRC cis rs7927771 0.832 rs56030824 chr11:47397353 G/A cg18512352 chr11:47633146 NA -0.4 -7.62 -0.39 2.73e-13 Subjective well-being; CRC cis rs6502050 0.799 rs6502078 chr17:80124364 G/A cg25804541 chr17:80189381 SLC16A3 -0.31 -5.95 -0.31 6.84e-9 Life satisfaction; CRC cis rs3020333 0.653 rs851984 chr6:152023191 G/A cg22157087 chr6:152012887 ESR1 0.48 7.21 0.37 3.75e-12 Total body bone mineral density; CRC cis rs7216064 1.000 rs62084213 chr17:65842016 A/G cg12091567 chr17:66097778 LOC651250 -0.68 -7.87 -0.4 5.31e-14 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CRC cis rs12540874 0.507 rs4947644 chr7:50618876 C/T cg14593290 chr7:50529359 DDC 0.44 6.47 0.34 3.47e-10 Systemic sclerosis; CRC cis rs28386778 0.863 rs8076760 chr17:61920497 T/C cg22520471 chr17:61851767 DDX42;CCDC47 0.75 11.71 0.54 1.02e-26 Prudent dietary pattern; CRC cis rs7927771 0.524 rs4752865 chr11:47759841 G/A cg20307385 chr11:47447363 PSMC3 -0.45 -6.45 -0.34 3.89e-10 Subjective well-being; CRC trans rs6550704 0.687 rs9865314 chr3:22634337 A/G cg07185584 chr20:19997881 NAA20 -0.43 -6.4 -0.33 5.34e-10 Daytime sleep phenotypes; CRC cis rs8062405 1.000 rs62037367 chr16:28874547 C/G cg16576597 chr16:28551801 NUPR1 0.48 6.82 0.35 4.39e-11 Cognitive ability (multi-trait analysis);Cognitive ability; CRC cis rs698833 0.886 rs2927433 chr2:44580737 T/A cg04920474 chr2:44395004 PPM1B 0.41 6.14 0.32 2.44e-9 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; CRC cis rs7727544 0.716 rs72793278 chr5:131561372 C/A cg18758796 chr5:131593413 PDLIM4 0.34 6.19 0.32 1.76e-9 Blood metabolite levels; CRC cis rs208520 0.955 rs17644076 chr6:67004973 A/G cg07460842 chr6:66804631 NA -0.82 -10.13 -0.49 3.73e-21 Exhaled nitric oxide output; CRC cis rs13392177 0.660 rs12988046 chr2:219073804 A/G cg00012203 chr2:219082015 ARPC2 -0.51 -7.46 -0.38 7.73e-13 Pyoderma gangrenosum in inflammatory bowel disease; CRC cis rs889312 0.500 rs832570 chr5:56156408 G/A cg24531977 chr5:56204891 C5orf35 -0.44 -6.78 -0.35 5.51e-11 Breast cancer;Breast cancer (early onset); CRC cis rs9308731 0.644 rs1054873 chr2:111876148 G/A cg18646521 chr2:111875858 NA 0.37 5.77 0.3 1.87e-8 Chronic lymphocytic leukemia; CRC cis rs798554 0.704 rs798513 chr7:2782493 C/T cg13628971 chr7:2884303 GNA12 0.44 6.95 0.36 1.99e-11 Height; CRC cis rs2969070 1.000 rs917079 chr7:2514181 C/T cg03277898 chr7:2518824 NA -0.45 -6.63 -0.34 1.4e-10 Diastolic blood pressure; CRC cis rs1030877 0.960 rs3792049 chr2:105901908 A/C cg02079111 chr2:105885981 TGFBRAP1 -0.65 -11.06 -0.52 2.27e-24 Obesity-related traits; CRC cis rs17401966 0.624 rs6696978 chr1:10209557 C/T cg19773385 chr1:10388646 KIF1B 0.48 6.62 0.34 1.42e-10 Hepatocellular carcinoma; CRC cis rs1395 0.778 rs2580761 chr2:27426362 G/A cg14242246 chr2:27434262 C2orf28;SLC5A6 0.4 7.38 0.38 1.32e-12 Blood metabolite levels; CRC cis rs7208859 0.623 rs73269974 chr17:29112384 C/T cg13385521 chr17:29058706 SUZ12P 0.73 8.4 0.42 1.39e-15 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs6546324 0.559 rs4381768 chr2:67779388 T/C cg15745817 chr2:67799979 NA -0.52 -8.3 -0.42 2.63e-15 Endometriosis; CRC cis rs7713065 0.531 rs2522051 chr5:131797578 C/T cg11843238 chr5:131593191 PDLIM4 0.35 6.42 0.33 4.68e-10 Lung function (FEV1/FVC); CRC cis rs9768139 0.708 rs896782 chr7:158114115 G/A cg23298862 chr7:158159286 PTPRN2 0.39 6.16 0.32 2.1e-9 Calcium levels; CRC cis rs736408 0.562 rs2072390 chr3:52780509 A/T cg08222913 chr3:52553049 STAB1 -0.35 -6.52 -0.34 2.61e-10 Bipolar disorder; CRC cis rs7615952 0.515 rs4441610 chr3:125681307 C/G cg05084668 chr3:125655381 ALG1L -0.65 -10.12 -0.49 3.77e-21 Blood pressure (smoking interaction); CRC cis rs281302 0.621 rs6493278 chr15:47730015 C/T cg13159054 chr15:47721715 NA 0.36 5.72 0.3 2.35e-8 Educational attainment (years of education);Cognitive ability (multi-trait analysis); CRC cis rs2019137 0.539 rs11123170 chr2:113978940 C/G cg01577475 chr2:114033581 PAX8;LOC440839 -0.26 -6.53 -0.34 2.46e-10 Lymphocyte counts; CRC cis rs490234 0.702 rs4838277 chr9:128367886 C/T cg14078157 chr9:128172775 NA -0.4 -6.48 -0.34 3.35e-10 Mean arterial pressure; CRC cis rs2019137 0.560 rs6707386 chr2:113981022 G/A cg09704166 chr2:114031854 PAX8;LOC440839 -0.36 -6.62 -0.34 1.46e-10 Lymphocyte counts; CRC cis rs10979 1.000 rs12203151 chr6:143884856 C/T cg25407410 chr6:143891975 LOC285740 -0.79 -12.87 -0.58 5.35e-31 Hypospadias; CRC cis rs2493151 1.000 rs1317181 chr1:230873488 G/T cg07502417 chr1:230849801 AGT 0.31 5.98 0.31 5.81e-9 Blood protein levels; CRC cis rs763014 0.932 rs2384972 chr16:674424 G/A cg04497992 chr16:616212 NHLRC4 0.44 6.96 0.36 1.89e-11 Height; CRC cis rs4889855 0.530 rs4890052 chr17:78564245 G/T cg16591659 chr17:78472290 NA 0.42 6.02 0.31 4.77e-9 Fractional excretion of uric acid; CRC cis rs7605378 1.000 rs796363 chr2:200693668 T/C cg23649088 chr2:200775458 C2orf69 0.56 7.9 0.4 4.27e-14 Osteoporosis; CRC cis rs1218582 0.772 rs4240874 chr1:154885779 C/T cg03351412 chr1:154909251 PMVK 0.54 8.73 0.43 1.26e-16 Prostate cancer; CRC cis rs6740322 0.895 rs10172375 chr2:43572047 A/G cg06169590 chr2:43455088 ZFP36L2;LOC100129726 -0.69 -8.69 -0.43 1.71e-16 Coronary artery disease; CRC cis rs1577917 0.958 rs1414199 chr6:86522370 T/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.5 -6.63 -0.34 1.34e-10 Response to antipsychotic treatment; CRC cis rs798554 0.757 rs1713919 chr7:2864706 C/A cg13628971 chr7:2884303 GNA12 0.54 7.35 0.38 1.56e-12 Height; CRC cis rs12530845 0.830 rs73721678 chr7:135355710 T/G cg23117316 chr7:135346802 PL-5283 -0.45 -6.21 -0.32 1.57e-9 Red blood cell traits; CRC cis rs56873913 0.904 rs7251295 chr19:50096859 G/C cg15963326 chr19:50037085 RCN3 -0.37 -5.81 -0.31 1.47e-8 Schizophrenia; CRC cis rs6860806 0.603 rs112300250 chr5:131583292 G/A cg20512303 chr5:131592959 PDLIM4 0.35 6.59 0.34 1.75e-10 Breast cancer; CRC cis rs10504229 0.683 rs16921807 chr8:58105967 C/T cg02725872 chr8:58115012 NA -0.66 -11.36 -0.53 1.85e-25 Developmental language disorder (linguistic errors); CRC trans rs875971 0.660 rs2191268 chr7:66110224 C/T cg07742235 chr11:69308752 NA 0.37 6.11 0.32 2.82e-9 Aortic root size; CRC cis rs10791323 0.592 rs2851115 chr11:133705381 C/A cg15485101 chr11:133734466 NA 0.41 6.84 0.35 3.85e-11 Childhood ear infection; CRC cis rs7727544 0.618 rs2631367 chr5:131705458 C/G cg12564285 chr5:131593104 PDLIM4 -0.36 -6.5 -0.34 2.96e-10 Blood metabolite levels; CRC cis rs4474465 1.000 rs10793316 chr11:78211928 C/A cg27205649 chr11:78285834 NARS2 0.48 5.83 0.31 1.35e-8 Alzheimer's disease (survival time); CRC cis rs769267 1.000 rs7246748 chr19:19433105 C/T cg01262667 chr19:19385393 TM6SF2 -0.37 -6.21 -0.32 1.58e-9 Tonsillectomy; CRC cis rs4700695 0.719 rs40176 chr5:65464965 C/T cg21114390 chr5:65439923 SFRS12 -0.65 -8.61 -0.43 3.14e-16 Facial morphology (factor 19); CRC cis rs4268898 0.552 rs11125455 chr2:24374557 C/G cg06627628 chr2:24431161 ITSN2 0.45 6.87 0.35 3.2e-11 Asthma; CRC cis rs9549367 0.789 rs6577031 chr13:113878182 T/C cg18105134 chr13:113819100 PROZ 0.74 11.69 0.54 1.24e-26 Platelet distribution width; CRC cis rs3096299 0.967 rs2911256 chr16:89485096 G/C cg01788221 chr16:89496183 ANKRD11 -0.44 -6.85 -0.35 3.75e-11 Multiple myeloma (IgH translocation); CRC cis rs9322193 0.923 rs9800580 chr6:149953981 C/T cg13206674 chr6:150067644 NUP43 0.65 9.76 0.47 6.33e-20 Lung cancer; CRC cis rs4665809 0.838 rs6546749 chr2:26306288 T/C cg27170947 chr2:26402098 FAM59B -0.45 -5.72 -0.3 2.43e-8 Gut microbiome composition (summer); CRC cis rs1401999 0.932 rs4148557 chr3:183733784 A/G cg20387954 chr3:183756860 HTR3D 0.46 7.93 0.4 3.46e-14 Anterior chamber depth; CRC cis rs13108904 0.521 rs4974609 chr4:1356924 A/C cg23123621 chr4:1343375 KIAA1530 -0.36 -6.46 -0.34 3.74e-10 Obesity-related traits; CRC cis rs2645694 0.626 rs2703143 chr4:77830441 A/G cg18351406 chr4:77819688 ANKRD56 0.51 7.6 0.39 3.1400000000000003e-13 Emphysema distribution in smoking; CRC cis rs4148883 0.545 rs17595102 chr4:99986316 C/G cg13256891 chr4:100009986 ADH5 0.46 6.33 0.33 7.9e-10 Alcohol dependence; CRC cis rs1223397 0.702 rs13191897 chr6:13288428 G/A cg06879394 chr6:13274151 PHACTR1 0.54 6.23 0.33 1.39e-9 Blood pressure; CRC cis rs9648716 1.000 rs7803738 chr7:140442819 C/T cg10747023 chr7:140774559 NA 0.45 5.8 0.3 1.52e-8 Type 2 diabetes; CRC cis rs7635838 0.892 rs12163566 chr3:11483096 T/A cg00170343 chr3:11313890 ATG7 0.41 6.29 0.33 1.02e-9 HDL cholesterol; CRC cis rs4713118 0.955 rs34752872 chr6:27683244 A/T cg15845792 chr6:28175446 NA 0.59 7.63 0.39 2.61e-13 Parkinson's disease; CRC cis rs3796352 1.000 rs114562844 chr3:52991584 C/T cg27565382 chr3:53032988 SFMBT1 0.7 6.19 0.32 1.76e-9 Immune reponse to smallpox (secreted IL-2); CRC cis rs17376456 0.877 rs10072592 chr5:93405989 C/G cg21475434 chr5:93447410 FAM172A 0.74 7.58 0.39 3.47e-13 Diabetic retinopathy; CRC cis rs3772130 0.583 rs9819530 chr3:121387784 T/G cg20356878 chr3:121714668 ILDR1 0.56 10.23 0.49 1.62e-21 Cognitive performance; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg08722104 chr11:47448306 PSMC3 0.56 7.24 0.37 3.18e-12 Thyroid stimulating hormone; CRC cis rs9910055 0.762 rs2240226 chr17:42266218 C/T cg09913183 chr17:42254507 C17orf65;ASB16 0.6 8.72 0.43 1.44e-16 Total body bone mineral density; CRC cis rs11864453 0.647 rs2550035 chr16:72113416 C/G cg23815491 chr16:72088622 HP 0.51 7.69 0.39 1.77e-13 Fibrinogen levels; CRC cis rs4665809 1.000 rs2384321 chr2:26290054 A/G cg04944784 chr2:26401820 FAM59B -0.65 -8.02 -0.4 1.93e-14 Gut microbiome composition (summer); CRC cis rs12134245 0.747 rs11164912 chr1:92005191 A/T cg25838465 chr1:92012736 NA -0.68 -12.64 -0.57 3.93e-30 Breast cancer; CRC cis rs2179367 0.959 rs9377212 chr6:149704901 G/C cg07828024 chr6:149772892 ZC3H12D -0.37 -6.34 -0.33 7.73e-10 Dupuytren's disease; CRC cis rs2463822 1.000 rs2513749 chr11:62105391 C/T cg06239285 chr11:62104954 ASRGL1 0.95 11.2 0.53 7.25e-25 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs970548 0.954 rs61854096 chr10:45981184 A/C cg15590007 chr10:45870220 ALOX5 0.47 5.97 0.31 6.15e-9 Total cholesterol levels;Cholesterol, total;HDL cholesterol;HDL cholesterol levels; CRC cis rs1707322 0.721 rs10749856 chr1:46164846 A/T cg03146154 chr1:46216737 IPP 0.67 9.82 0.48 3.95e-20 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs7945705 0.747 rs10840158 chr11:9020897 A/C cg12365402 chr11:9010492 NRIP3 -0.61 -11.51 -0.54 5.62e-26 Hemoglobin concentration; CRC cis rs870825 0.587 rs35845099 chr4:185639762 A/G cg04058563 chr4:185651563 MLF1IP 0.73 9.41 0.46 9.01e-19 Blood protein levels; CRC cis rs7772486 0.641 rs9390374 chr6:146368175 A/T cg13319975 chr6:146136371 FBXO30 -0.52 -7.47 -0.38 7.32e-13 Lobe attachment (rater-scored or self-reported); CRC cis rs933688 0.941 rs6452954 chr5:90735692 G/A cg26981201 chr5:90679533 LOC100129716;ARRDC3 0.97 17.31 0.69 3.4e-48 Smoking behavior; CRC cis rs9467711 0.606 rs2073531 chr6:26375256 A/G cg16898833 chr6:26189333 HIST1H4D 0.75 6.55 0.34 2.26e-10 Autism spectrum disorder or schizophrenia; CRC cis rs2075671 0.855 rs11974395 chr7:100282538 G/A cg16850897 chr7:100343110 ZAN -0.61 -8.98 -0.44 2.11e-17 Other erythrocyte phenotypes; CRC cis rs1552244 0.572 rs7645667 chr3:10157337 C/A cg13047869 chr3:10149882 C3orf24 0.57 6.77 0.35 5.94e-11 Alzheimer's disease; CRC cis rs9462846 0.658 rs9471970 chr6:42913646 G/A cg27588902 chr6:42928151 GNMT -0.34 -5.61 -0.3 4.2e-8 Blood protein levels; CRC cis rs1008375 0.898 rs7678654 chr4:17575376 T/G cg16339924 chr4:17578868 LAP3 0.6 7.86 0.4 5.4e-14 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs910316 1.000 rs4903281 chr14:75554361 G/C cg03030879 chr14:75389066 RPS6KL1 -0.47 -7.38 -0.38 1.3e-12 Height; CRC cis rs9649213 0.593 rs3801254 chr7:98010811 G/A cg21770322 chr7:97807741 LMTK2 0.52 8.56 0.43 4.41e-16 Prostate cancer (SNP x SNP interaction); CRC cis rs929354 0.713 rs3802130 chr7:156965237 A/G cg17757837 chr7:157058334 UBE3C 0.74 12.39 0.56 3.31e-29 Body mass index; CRC cis rs2976388 0.556 rs4736300 chr8:143829269 C/T cg12516270 chr8:143859308 LYNX1 -0.4 -6.29 -0.33 9.94e-10 Urinary tract infection frequency; CRC cis rs881375 1.000 rs6478486 chr9:123655329 T/C cg09586646 chr9:123605570 PSMD5;LOC253039 0.53 7.17 0.37 4.85e-12 Rheumatoid arthritis; CRC cis rs6880778 0.505 rs10072596 chr5:40407033 A/G cg09067459 chr5:40385259 NA 0.45 7.79 0.39 8.88e-14 Inflammatory bowel disease; CRC cis rs9322193 0.923 rs10782318 chr6:150075273 A/G cg04369109 chr6:150039330 LATS1 -0.43 -5.75 -0.3 2.08e-8 Lung cancer; CRC cis rs708547 0.578 rs781665 chr4:57831461 G/A cg25525207 chr4:57843836 C4orf14;POLR2B -0.46 -6.39 -0.33 5.66e-10 Response to bleomycin (chromatid breaks); CRC trans rs55675132 0.548 rs79671603 chr1:115377698 A/T cg25493687 chr8:27288214 PTK2B 0.49 6.0 0.31 5.23e-9 Schizophrenia; CRC trans rs11039798 0.528 rs10769559 chr11:49032446 T/C cg03929089 chr4:120376271 NA 0.58 6.16 0.32 2.15e-9 Axial length; CRC cis rs2882667 0.690 rs160402 chr5:138059288 G/T cg09476006 chr5:138032270 NA 0.56 9.65 0.47 1.4e-19 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs881375 0.967 rs10733648 chr9:123700779 A/G cg09586646 chr9:123605570 PSMD5;LOC253039 0.48 6.54 0.34 2.42e-10 Rheumatoid arthritis; CRC cis rs7246657 0.943 rs10403613 chr19:37844306 C/T cg23950597 chr19:37808831 NA -0.54 -6.5 -0.34 2.93e-10 Coronary artery calcification; CRC cis rs10128264 0.935 rs1250575 chr10:80963546 A/G cg20744163 chr10:80999841 ZMIZ1 0.34 6.1 0.32 2.99e-9 Response to methotrexate in juvenile idiopathic arthritis; CRC cis rs2364543 0.624 rs61774752 chr1:41847024 T/C cg01193554 chr1:41846683 NA -0.38 -6.11 -0.32 2.78e-9 Intelligence (multi-trait analysis); CRC cis rs10992471 0.603 rs4743873 chr9:95270781 C/T cg13798575 chr9:95087839 CENPP;NOL8 0.43 5.7 0.3 2.7e-8 Visceral adipose tissue/subcutaneous adipose tissue ratio; CRC cis rs9517320 0.534 rs9554477 chr13:99160379 C/T cg20487152 chr13:99095054 FARP1 -0.46 -7.05 -0.36 1.05e-11 Longevity; CRC cis rs863345 0.604 rs4373761 chr1:158464634 G/A cg12129480 chr1:158549410 OR10X1 -0.3 -6.29 -0.33 9.9e-10 Pneumococcal bacteremia; CRC cis rs6496667 0.865 rs7169196 chr15:90877484 C/T cg04176472 chr15:90893244 GABARAPL3 0.6 7.17 0.37 5.13e-12 Rheumatoid arthritis; CRC cis rs4713118 0.662 rs464312 chr6:27967591 T/A cg23161317 chr6:28129485 ZNF389 0.47 6.64 0.34 1.28e-10 Parkinson's disease; CRC cis rs2806561 0.765 rs605367 chr1:23518524 T/C cg12483005 chr1:23474871 LUZP1 0.49 7.22 0.37 3.69e-12 Height; CRC cis rs2732480 0.500 rs1387257 chr12:48636666 C/A cg04545296 chr12:48745243 ZNF641 0.33 5.75 0.3 2.05e-8 Hemoglobin concentration;Red blood cell count;Hematocrit; CRC cis rs7429990 0.932 rs7630685 chr3:48131170 G/C cg11946769 chr3:48343235 NME6 -0.47 -5.93 -0.31 7.73e-9 Educational attainment (years of education); CRC cis rs515186 1 rs515186 chr6:36397492 T/G cg04289385 chr6:36355825 ETV7 0.39 5.71 0.3 2.48e-8 Mean platelet volume; CRC cis rs4253772 0.744 rs9627278 chr22:46643432 C/G cg09491104 chr22:46646882 C22orf40 -0.37 -5.82 -0.31 1.4e-8 LDL cholesterol;Cholesterol, total; CRC cis rs12477438 0.520 rs12621007 chr2:99791946 G/C cg26064155 chr2:99771622 LIPT1;TSGA10 0.88 16.21 0.67 7.23e-44 Chronic sinus infection; CRC cis rs10256972 0.933 rs35696159 chr7:1047194 A/G cg07930192 chr7:1003750 NA 0.43 6.48 0.34 3.32e-10 Longevity;Endometriosis; CRC cis rs7173389 0.551 rs78060843 chr15:73683583 G/T cg01796676 chr15:73680284 NA 0.6 5.92 0.31 8.09e-9 Resting heart rate; CRC cis rs7769051 1.000 rs7769051 chr6:133146796 G/T cg22852734 chr6:133119734 C6orf192 0.86 9.7 0.47 9.59e-20 Type 2 diabetes nephropathy; CRC cis rs172166 0.652 rs476167 chr6:28065888 T/C cg23161317 chr6:28129485 ZNF389 0.46 6.46 0.34 3.68e-10 Cardiac Troponin-T levels; CRC cis rs9372498 0.536 rs62422228 chr6:118957276 T/C cg18833306 chr6:118973337 C6orf204 0.46 5.88 0.31 1.01e-8 Diastolic blood pressure; CRC cis rs77861329 1.000 rs2304505 chr3:52184760 T/C cg08692210 chr3:52188851 WDR51A 0.83 7.76 0.39 1.08e-13 Macrophage inflammatory protein 1b levels; CRC cis rs2806561 1.000 rs654585 chr1:23514714 T/C cg12483005 chr1:23474871 LUZP1 0.39 5.63 0.3 3.85e-8 Height; CRC cis rs4862750 0.914 rs1346126 chr4:187876404 T/C cg06074448 chr4:187884817 NA -0.59 -11.06 -0.52 2.24e-24 Lobe attachment (rater-scored or self-reported); CRC trans rs1814175 0.630 rs1722019 chr11:49904102 G/A cg11707556 chr5:10655725 ANKRD33B -0.37 -6.96 -0.36 1.85e-11 Height; CRC cis rs9911578 1.000 rs302840 chr17:56673079 C/G cg12560992 chr17:57184187 TRIM37 0.91 16.88 0.68 1.72e-46 Intelligence (multi-trait analysis); CRC cis rs10927875 0.541 rs1739844 chr1:16343322 T/C cg24140574 chr1:16342155 HSPB7 0.47 6.74 0.35 7.16e-11 Dilated cardiomyopathy; CRC cis rs1862618 0.853 rs2113078 chr5:56087190 C/T cg20203395 chr5:56204925 C5orf35 -0.73 -8.7 -0.43 1.66e-16 Initial pursuit acceleration; CRC cis rs1568889 1.000 rs12803716 chr11:28055111 A/G cg06544937 chr11:28130018 METT5D1;KIF18A 0.78 11.27 0.53 3.9e-25 Bipolar disorder; CRC cis rs1451375 1.000 rs1966839 chr7:50627101 T/C cg18232548 chr7:50535776 DDC 0.46 6.46 0.34 3.68e-10 Malaria; CRC cis rs7119 0.689 rs12901765 chr15:77819103 C/A cg27398640 chr15:77910606 LINGO1 -0.44 -7.53 -0.38 5e-13 Type 2 diabetes; CRC cis rs7605827 0.704 rs3732001 chr2:15536872 T/C cg19274914 chr2:15703543 NA 0.39 5.87 0.31 1.06e-8 Educational attainment (years of education); CRC cis rs2979489 0.786 rs1106352 chr8:30404671 C/T cg26383811 chr8:30366931 RBPMS -0.67 -9.7 -0.47 1.01e-19 Mean corpuscular hemoglobin;Plateletcrit;Neutrophil count;Granulocyte count;Sum basophil neutrophil counts;Mean corpuscular volume;Myeloid white cell count;Sum neutrophil eosinophil counts; CRC cis rs12523822 0.913 rs2056370 chr6:154967167 T/G cg20019720 chr6:154832845 CNKSR3 0.27 5.82 0.31 1.4e-8 Diabetic kidney disease; CRC cis rs8177253 0.665 rs9869257 chr3:133451412 G/T cg16262614 chr3:133464971 TF 0.4 7.09 0.36 8.42e-12 Iron status biomarkers; CRC cis rs3857536 0.813 rs9354403 chr6:66943426 A/G cg07460842 chr6:66804631 NA -0.43 -5.78 -0.3 1.72e-8 Blood trace element (Cu levels); CRC trans rs56052703 0.702 rs10421428 chr19:13433348 C/T cg07875759 chr21:43639080 ABCG1 0.48 6.21 0.32 1.59e-9 Proteinuria and chronic kidney disease; CRC cis rs6502050 0.835 rs4459614 chr17:80086597 C/T cg13198984 chr17:80129470 CCDC57 -0.48 -8.47 -0.42 8.34e-16 Life satisfaction; CRC cis rs4660306 1.000 rs6667191 chr1:45982844 A/G cg03123370 chr1:45965343 CCDC163P;MMACHC -0.56 -7.83 -0.4 6.68e-14 Homocysteine levels; CRC cis rs8060686 0.920 rs2271293 chr16:67902070 A/G cg19582491 chr16:67682965 RLTPR 0.53 6.08 0.32 3.25e-9 HDL cholesterol;Metabolic syndrome; CRC cis rs6502050 0.830 rs8074436 chr17:80158422 A/G cg13198984 chr17:80129470 CCDC57 0.45 8.01 0.4 1.99e-14 Life satisfaction; CRC cis rs11764590 0.715 rs11766468 chr7:2082604 G/A cg02825527 chr7:2087843 MAD1L1 -0.5 -6.07 -0.32 3.54e-9 Neuroticism; CRC cis rs34172651 0.571 rs9922156 chr16:24704329 C/A cg06028605 chr16:24865363 SLC5A11 -0.44 -6.98 -0.36 1.62e-11 Intelligence (multi-trait analysis); CRC cis rs6504622 0.755 rs34038545 chr17:45144907 G/C cg16759221 chr17:45003025 GOSR2 0.44 6.76 0.35 6.26e-11 Orofacial clefts; CRC cis rs1949733 1.000 rs1880023 chr4:8480831 C/T cg11789530 chr4:8429930 ACOX3 -0.83 -12.82 -0.58 8.3e-31 Response to antineoplastic agents; CRC cis rs8180040 0.620 rs749511 chr3:47035735 A/C cg02527881 chr3:46936655 PTH1R 0.32 5.72 0.3 2.42e-8 Colorectal cancer; CRC cis rs9818758 0.556 rs9813813 chr3:49207093 T/A cg07636037 chr3:49044803 WDR6 -0.84 -6.41 -0.33 5.07e-10 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; CRC cis rs4499344 0.577 rs259289 chr19:33164927 G/C cg08127369 chr19:33164662 ANKRD27 0.39 6.01 0.31 5.02e-9 Mean platelet volume; CRC trans rs11039798 0.588 rs10160381 chr11:48599491 A/G cg15704280 chr7:45808275 SEPT13 0.65 7.04 0.36 1.13e-11 Axial length; CRC cis rs10927875 0.864 rs12135073 chr1:16167799 C/T cg21385522 chr1:16154831 NA 0.89 10.65 0.51 5.85e-23 Dilated cardiomyopathy; CRC trans rs11165623 0.765 rs12749081 chr1:96970371 A/C cg10631902 chr5:14652156 NA -0.48 -8.88 -0.44 4.54e-17 Hip circumference;Waist circumference; CRC cis rs9660992 0.967 rs1172135 chr1:205247160 G/C cg21643547 chr1:205240462 TMCC2 -0.41 -6.65 -0.34 1.23e-10 Mean corpuscular volume;Mean platelet volume; CRC cis rs9969804 0.782 rs10761169 chr9:95515033 T/C cg14631576 chr9:95140430 CENPP -0.31 -5.64 -0.3 3.59e-8 Height; CRC cis rs4638749 0.677 rs1522021 chr2:108833263 C/T cg25838818 chr2:108905173 SULT1C2 -0.34 -5.75 -0.3 2.01e-8 Blood pressure; CRC cis rs7705042 0.793 rs10463348 chr5:141502035 G/T cg08523384 chr5:141488047 NDFIP1 -0.34 -6.08 -0.32 3.29e-9 Asthma; CRC cis rs9291683 0.595 rs35501905 chr4:10053431 C/T cg00071950 chr4:10020882 SLC2A9 0.65 12.17 0.56 2.2e-28 Bone mineral density; CRC cis rs2243480 1.000 rs35820085 chr7:65442758 C/T cg25985355 chr7:65971099 NA -0.49 -5.85 -0.31 1.19e-8 Diabetic kidney disease; CRC cis rs9814567 0.806 rs9839705 chr3:134323819 T/C cg06109529 chr3:134205091 CEP63;ANAPC13 -0.68 -10.11 -0.49 4.11e-21 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs7937682 0.889 rs1784787 chr11:111486125 T/A cg19812747 chr11:111475976 SIK2 -0.59 -10.14 -0.49 3.31e-21 Primary sclerosing cholangitis; CRC cis rs6840360 1.000 rs17360475 chr4:152671640 C/G cg09659197 chr4:152720779 NA -0.49 -10.52 -0.5 1.65e-22 Intelligence (multi-trait analysis); CRC cis rs796364 0.762 rs13030712 chr2:200973569 G/A cg23649088 chr2:200775458 C2orf69 0.55 7.26 0.37 2.74e-12 Schizophrenia; CRC cis rs11190604 1.000 rs12358187 chr10:102284449 C/G cg07080220 chr10:102295463 HIF1AN 0.47 5.64 0.3 3.61e-8 Palmitoleic acid (16:1n-7) levels; CRC cis rs1129187 0.686 rs6458313 chr6:42922018 A/G cg21280719 chr6:42927975 GNMT -0.48 -10.5 -0.5 1.96e-22 Alzheimer's disease in APOE e4+ carriers; CRC cis rs939584 0.935 rs10166979 chr2:640701 A/G cg03610516 chr2:642275 NA 0.42 5.88 0.31 9.94e-9 Body mass index; CRC cis rs4332037 0.522 rs4721098 chr7:1881527 G/C cg25834613 chr7:1915315 MAD1L1 0.39 6.05 0.32 3.96e-9 Bipolar disorder; CRC cis rs12476592 0.602 rs964880 chr2:63826932 C/A cg10828910 chr2:63850056 LOC388955 0.5 6.13 0.32 2.54e-9 Childhood ear infection; CRC cis rs2976388 0.573 rs1529865 chr8:143789171 C/T cg24046110 chr8:143859143 LYNX1 0.47 8.18 0.41 6.22e-15 Urinary tract infection frequency; CRC cis rs1448094 0.512 rs12314274 chr12:86249196 A/G cg02569458 chr12:86230093 RASSF9 0.43 7.43 0.38 9.28e-13 Major depressive disorder; CRC cis rs3096299 0.503 rs4785677 chr16:89555101 A/G cg00750074 chr16:89608354 SPG7 -0.49 -7.3 -0.37 2.25e-12 Multiple myeloma (IgH translocation); CRC cis rs2120019 1.000 rs12185102 chr15:75352201 G/A cg09165964 chr15:75287851 SCAMP5 -0.83 -12.79 -0.58 1.11e-30 Blood trace element (Zn levels); CRC cis rs12477438 0.520 rs13010904 chr2:99754289 G/A cg14399236 chr2:99771627 LIPT1;TSGA10 0.84 14.99 0.64 4.43e-39 Chronic sinus infection; CRC cis rs11628318 0.614 rs3825565 chr14:103060465 G/A cg12046867 chr14:103022105 NA -0.77 -9.19 -0.45 4.41e-18 Platelet count; CRC trans rs7395662 0.504 rs11039701 chr11:48389838 A/G cg21153622 chr11:89784906 NA -0.49 -8.18 -0.41 6.47e-15 HDL cholesterol; CRC cis rs1862618 0.853 rs33325 chr5:56142547 G/C cg22800045 chr5:56110881 MAP3K1 0.56 6.21 0.32 1.59e-9 Initial pursuit acceleration; CRC cis rs68170813 0.559 rs75313693 chr7:106863170 T/C cg02696742 chr7:106810147 HBP1 -0.6 -6.58 -0.34 1.83e-10 Coronary artery disease; CRC cis rs7618915 0.547 rs2118540 chr3:52629386 T/C cg05573699 chr3:52720067 GNL3;PBRM1 -0.44 -6.27 -0.33 1.16e-9 Bipolar disorder; CRC cis rs1552244 1.000 rs6782602 chr3:10116541 G/T cg10729496 chr3:10149963 C3orf24 0.5 6.78 0.35 5.69e-11 Alzheimer's disease; CRC cis rs3790645 0.645 rs3790644 chr1:26884676 G/A cg23229016 chr1:26872525 RPS6KA1 0.29 5.82 0.31 1.41e-8 Glucose homeostasis traits; CRC cis rs1552244 0.882 rs13066757 chr3:10045030 C/A cg16606324 chr3:10149918 C3orf24 0.64 8.43 0.42 1.13e-15 Alzheimer's disease; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg25662041 chr5:176759170 LMAN2 0.26 5.96 0.31 6.34e-9 Liver disease severity in Alagille syndrome; CRC cis rs9463078 0.647 rs6933449 chr6:45325151 G/C cg25276700 chr6:44698697 NA 0.25 5.94 0.31 7.36e-9 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; CRC cis rs1707322 0.691 rs11211174 chr1:46220816 C/G cg06784218 chr1:46089804 CCDC17 0.66 12.27 0.56 9.04e-29 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs12701220 0.500 rs6463224 chr7:1140418 C/A cg02733842 chr7:1102375 C7orf50 -0.56 -7.01 -0.36 1.34e-11 Bronchopulmonary dysplasia; CRC cis rs644799 0.710 rs522536 chr11:95528714 C/T cg25478527 chr11:95522999 CEP57;FAM76B 0.48 7.52 0.38 5.35e-13 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs8177253 0.965 rs3811658 chr3:133476852 C/T cg11941060 chr3:133502564 NA -0.58 -10.2 -0.49 2.15e-21 Iron status biomarkers; CRC cis rs4629710 0.568 rs9492883 chr6:131573872 A/T cg12606694 chr6:131520996 AKAP7 0.56 8.32 0.42 2.39e-15 Multiple myeloma (IgH translocation); CRC cis rs861020 1.000 rs680923 chr1:209986672 T/C cg05527609 chr1:210001259 C1orf107 0.98 12.39 0.56 3.49e-29 Orofacial clefts; CRC cis rs11190604 0.767 rs12360395 chr10:102194074 A/T cg16342193 chr10:102329863 NA -0.34 -5.68 -0.3 2.92e-8 Palmitoleic acid (16:1n-7) levels; CRC cis rs12042938 0.507 rs1765777 chr1:231731742 C/T cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.61 -9.24 -0.45 3.2e-18 Neuranatomic and neurocognitive phenotypes; CRC cis rs9910055 1.000 rs2071167 chr17:42287519 A/G cg10896456 chr17:42255109 ASB16;C17orf65 -0.4 -6.72 -0.35 8.13e-11 Total body bone mineral density; CRC cis rs9443645 0.810 rs9361482 chr6:79750385 T/C cg11833968 chr6:79620685 NA -0.34 -5.67 -0.3 3.11e-8 Intelligence (multi-trait analysis); CRC cis rs853679 0.550 rs1225598 chr6:28160799 T/G cg21251018 chr6:28226885 NKAPL 0.46 6.57 0.34 1.97e-10 Depression; CRC cis rs7727544 0.735 rs274568 chr5:131713578 C/T cg21138405 chr5:131827807 IRF1 0.31 5.65 0.3 3.43e-8 Blood metabolite levels; CRC cis rs1552244 0.572 rs6442154 chr3:10168785 A/G cg18598329 chr3:10140678 FANCD2;C3orf24 -0.91 -10.81 -0.51 1.62e-23 Alzheimer's disease; CRC cis rs1215050 0.874 rs2167893 chr4:99048464 A/T cg05340658 chr4:99064831 C4orf37 0.44 6.22 0.32 1.54e-9 Waist-to-hip ratio adjusted for body mass index; CRC cis rs6502050 0.835 rs8080423 chr17:80102279 A/G cg25804541 chr17:80189381 SLC16A3 -0.31 -5.97 -0.31 6.08e-9 Life satisfaction; CRC cis rs875971 0.825 rs59466412 chr7:65565358 A/G cg18876405 chr7:65276391 NA -0.51 -8.49 -0.42 6.96e-16 Aortic root size; CRC cis rs67311347 0.910 rs7617361 chr3:40373259 G/T cg09455208 chr3:40491958 NA 0.43 8.88 0.44 4.37e-17 Renal cell carcinoma; CRC cis rs4285028 0.603 rs79312528 chr3:121608997 T/C cg20356878 chr3:121714668 ILDR1 -0.48 -6.58 -0.34 1.91e-10 Multiple sclerosis; CRC cis rs7591163 1.000 rs6436741 chr2:228714598 G/A cg01216370 chr2:228736459 WDR69 -0.45 -5.7 -0.3 2.68e-8 Blood pressure; CRC cis rs9914578 0.943 rs7225843 chr17:2001825 A/G cg16513277 chr17:2031491 SMG6 -0.45 -6.44 -0.33 4.17e-10 Body mass index; CRC cis rs769267 0.930 rs1047361 chr19:19606634 G/A cg02546618 chr19:19431379 KIAA0892;SF4 0.45 6.13 0.32 2.57e-9 Tonsillectomy; CRC cis rs1950626 0.796 rs7152870 chr14:101389987 T/A cg02351406 chr14:101447389 SNORD114-20;SNORD114-21 -0.92 -14.82 -0.63 1.95e-38 Pelvic organ prolapse (moderate/severe); CRC cis rs3849570 1.000 rs9818006 chr3:81828230 A/C cg07356753 chr3:81810745 GBE1 -0.58 -8.39 -0.42 1.41e-15 Waist circumference;Body mass index; CRC cis rs67311347 1.000 rs4973878 chr3:40407565 C/T cg24209194 chr3:40518798 ZNF619 0.42 6.46 0.34 3.71e-10 Renal cell carcinoma; CRC cis rs7786808 0.552 rs35809824 chr7:158185067 C/T cg01191920 chr7:158217561 PTPRN2 -0.74 -11.91 -0.55 1.87e-27 Obesity-related traits; CRC cis rs2404602 0.619 rs7342603 chr15:76982625 C/T cg22467129 chr15:76604101 ETFA -0.41 -6.78 -0.35 5.59e-11 Blood metabolite levels; CRC cis rs7727544 0.618 rs2631367 chr5:131705458 C/G cg18758796 chr5:131593413 PDLIM4 -0.32 -5.66 -0.3 3.37e-8 Blood metabolite levels; CRC cis rs7647973 0.626 rs9870858 chr3:49769071 C/T cg03060546 chr3:49711283 APEH 0.66 8.29 0.42 3e-15 Menarche (age at onset); CRC trans rs941408 0.515 rs759067 chr19:2775668 C/T cg22153745 chr1:153894579 GATAD2B -0.57 -7.45 -0.38 8.11e-13 Total cholesterol levels; CRC cis rs2204008 0.744 rs11182316 chr12:38499552 G/A cg26384229 chr12:38710491 ALG10B 0.71 9.54 0.47 3.27e-19 Bladder cancer; CRC cis rs7223966 1.000 rs56057198 chr17:61733332 G/A cg23090583 chr17:61904693 PSMC5;FTSJ3 0.58 6.69 0.35 9.55e-11 Hip circumference adjusted for BMI;Body mass index; CRC cis rs6912958 0.781 rs6454632 chr6:88231824 A/C cg08069147 chr6:88032118 GJB7;C6orf162 -0.57 -8.49 -0.42 7.34e-16 Monocyte percentage of white cells; CRC cis rs600231 0.708 rs2957269 chr11:65243007 C/G cg17120908 chr11:65337727 SSSCA1 -0.56 -8.34 -0.42 2.03e-15 Bone mineral density; CRC cis rs17270561 0.723 rs12213243 chr6:25890108 C/T cg16482183 chr6:26056742 HIST1H1C 0.88 11.26 0.53 4.43e-25 Iron status biomarkers; CRC trans rs6601327 0.606 rs4841203 chr8:9582730 A/G cg06636001 chr8:8085503 FLJ10661 -0.5 -7.39 -0.38 1.22e-12 Multiple myeloma (hyperdiploidy); CRC cis rs4588572 0.643 rs1159929 chr5:77768820 A/G cg11446398 chr5:77624930 NA -0.46 -6.24 -0.33 1.32e-9 Triglycerides; CRC cis rs3820068 0.581 rs111699992 chr1:15927158 G/A cg24675056 chr1:15929824 NA 0.49 6.77 0.35 5.87e-11 Systolic blood pressure; CRC cis rs453301 0.598 rs10104303 chr8:8834528 A/T cg06636001 chr8:8085503 FLJ10661 0.45 7.03 0.36 1.21e-11 Joint mobility (Beighton score); CRC cis rs3820068 0.603 rs3795763 chr1:15959977 C/T cg27534772 chr1:16042836 PLEKHM2 0.53 10.38 0.5 4.9e-22 Systolic blood pressure; CRC cis rs853679 0.517 rs17711344 chr6:28077602 A/G cg23161317 chr6:28129485 ZNF389 -0.55 -6.75 -0.35 6.73e-11 Depression; CRC cis rs9486719 1.000 rs2499804 chr6:96861216 A/G cg06623918 chr6:96969491 KIAA0776 0.79 9.27 0.46 2.56e-18 Migraine;Coronary artery disease; CRC cis rs7811142 1.000 rs1073 chr7:100031612 G/A cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.17 16.9 0.68 1.47e-46 Platelet count; CRC cis rs28386778 0.897 rs8073515 chr17:61795328 A/C cg25654072 chr17:61904446 PSMC5;FTSJ3 0.71 10.9 0.52 7.66e-24 Prudent dietary pattern; CRC cis rs9525927 0.625 rs9533801 chr13:44816569 A/G cg19190762 chr13:44806055 NA 0.46 5.97 0.31 6.16e-9 Dupuytren's disease; CRC cis rs9467711 0.720 rs1417998 chr6:26162019 T/A cg16898833 chr6:26189333 HIST1H4D 0.66 6.14 0.32 2.37e-9 Autism spectrum disorder or schizophrenia; CRC cis rs870825 0.790 rs12513128 chr4:185576729 G/C cg04058563 chr4:185651563 MLF1IP 0.6 6.17 0.32 1.98e-9 Blood protein levels; CRC cis rs372883 0.648 rs1153291 chr21:30689070 G/T cg08807101 chr21:30365312 RNF160 -0.52 -7.19 -0.37 4.37e-12 Pancreatic cancer; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg27547812 chr1:26437414 PDIK1L 0.45 5.97 0.31 6.05e-9 Anxiety disorder; CRC cis rs12711979 0.509 rs13035992 chr2:3826597 G/A cg17052675 chr2:3827356 NA -0.86 -20.9 -0.76 2.59e-62 Itch intensity from mosquito bite adjusted by bite size; CRC cis rs7412746 0.611 rs6660084 chr1:150748803 T/C cg17724175 chr1:150552817 MCL1 0.48 7.08 0.36 8.66e-12 Melanoma; CRC cis rs1129187 0.755 rs2274517 chr6:42932715 A/G cg00597713 chr6:42947103 PEX6 0.42 6.03 0.32 4.43e-9 Alzheimer's disease in APOE e4+ carriers; CRC cis rs2836974 0.897 rs2836924 chr21:40525639 C/T cg11890956 chr21:40555474 PSMG1 1.1 21.14 0.76 3.07e-63 Cognitive function; CRC cis rs2836974 0.568 rs428602 chr21:40547004 A/G cg11890956 chr21:40555474 PSMG1 0.89 14.95 0.64 6.56e-39 Cognitive function; CRC cis rs2456568 0.564 rs6483270 chr11:93624380 C/T cg26875233 chr11:93583750 C11orf90 -0.31 -6.1 -0.32 3.01e-9 Response to serotonin reuptake inhibitors in major depressive disorder; CRC cis rs7107174 1.000 rs7939646 chr11:78111613 C/T cg02023728 chr11:77925099 USP35 -0.42 -7.06 -0.36 1e-11 Testicular germ cell tumor; CRC cis rs950169 0.920 rs17300048 chr15:84749477 C/T cg11189052 chr15:85197271 WDR73 0.6 8.83 0.44 6.13e-17 Schizophrenia; CRC cis rs10751667 0.666 rs7943140 chr11:973824 T/C cg06064525 chr11:970664 AP2A2 -0.3 -6.1 -0.32 3.06e-9 Alzheimer's disease (late onset); CRC cis rs853679 0.760 rs9468317 chr6:28198456 A/G cg03623178 chr6:28175578 NA 0.74 8.24 0.41 4.24e-15 Depression; CRC cis rs17401966 0.838 rs1538557 chr1:10297230 T/C cg19773385 chr1:10388646 KIF1B -0.66 -10.78 -0.51 2.04e-23 Hepatocellular carcinoma; CRC cis rs9486719 1.000 rs11153023 chr6:96968525 C/T cg18709589 chr6:96969512 KIAA0776 -0.52 -5.76 -0.3 1.92e-8 Migraine;Coronary artery disease; CRC cis rs79387448 0.745 rs1159509 chr2:103169073 T/A cg00507830 chr2:103233733 NA 0.54 6.0 0.31 5.34e-9 Gut microbiota (bacterial taxa); CRC cis rs7191439 0.790 rs2306046 chr16:88781419 A/G cg02389323 chr16:88786976 FAM38A 0.91 8.39 0.42 1.43e-15 Plateletcrit; CRC trans rs1005277 0.505 rs200935 chr10:38132810 T/A cg27523141 chr10:43048294 ZNF37B 0.44 6.44 0.33 4.17e-10 Extrinsic epigenetic age acceleration; CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg11027325 chr2:239148674 HES6 0.39 6.47 0.34 3.59e-10 Obesity-related traits; CRC cis rs1799949 1.000 rs8176289 chr17:41206056 T/C cg05368731 chr17:41323189 NBR1 0.68 10.3 0.49 9.6e-22 Menopause (age at onset); CRC cis rs7666738 0.830 rs991168 chr4:98928293 T/C cg17366294 chr4:99064904 C4orf37 0.43 7.32 0.37 1.95e-12 Colonoscopy-negative controls vs population controls; CRC cis rs950776 0.518 rs1979907 chr15:78842239 T/C cg06917634 chr15:78832804 PSMA4 -0.65 -10.36 -0.5 5.97e-22 Sudden cardiac arrest; CRC cis rs9733 0.519 rs72704603 chr1:150707992 C/T cg17724175 chr1:150552817 MCL1 0.59 9.43 0.46 7.86e-19 Tonsillectomy; CRC cis rs9649213 0.593 rs1859482 chr7:97983774 C/T cg00277769 chr7:97922759 BAIAP2L1 -0.6 -10.39 -0.5 4.76e-22 Prostate cancer (SNP x SNP interaction); CRC cis rs910316 0.712 rs175015 chr14:75457075 A/C cg11812906 chr14:75593930 NEK9 -0.59 -8.98 -0.44 2.1e-17 Height; CRC cis rs10946940 0.896 rs12208078 chr6:27498581 G/A cg06470822 chr6:28175283 NA -0.5 -6.85 -0.35 3.7e-11 Systemic lupus erythematosus; CRC cis rs2251381 0.515 rs2832299 chr21:30749237 G/C cg24692254 chr21:30365293 RNF160 0.52 8.27 0.41 3.38e-15 Selective IgA deficiency; CRC cis rs7605827 0.930 rs11893303 chr2:15613715 G/A cg19274914 chr2:15703543 NA 0.39 5.9 0.31 8.83e-9 Educational attainment (years of education); CRC cis rs12995491 0.731 rs55705009 chr2:88500718 T/G cg04511125 chr2:88470314 THNSL2 -0.43 -6.15 -0.32 2.31e-9 Response to metformin (IC50); CRC cis rs1580019 0.961 rs958217 chr7:32493417 A/G cg06627557 chr7:32535165 LSM5;AVL9 0.76 12.33 0.56 5.69e-29 Cognitive ability; CRC cis rs959260 0.588 rs12938183 chr17:73320433 G/C cg14668889 chr17:73230827 NUP85 -0.51 -7.5 -0.38 5.85e-13 Systemic lupus erythematosus; CRC cis rs561341 1.000 rs55962687 chr17:30260369 C/T cg23018236 chr17:30244563 NA -0.64 -7.5 -0.38 6.12e-13 Hip circumference adjusted for BMI; CRC cis rs881375 0.967 rs10435843 chr9:123668033 A/G cg14255062 chr9:123606675 PSMD5;LOC253039 0.42 6.06 0.32 3.7e-9 Rheumatoid arthritis; CRC cis rs2857891 0.909 rs17191140 chr11:6944283 G/A cg02416716 chr11:6948024 ZNF215 0.58 5.98 0.31 5.9e-9 Response to cytadine analogues (cytosine arabinoside); CRC cis rs881375 0.967 rs2270231 chr9:123650982 C/G cg14255062 chr9:123606675 PSMD5;LOC253039 0.43 6.25 0.33 1.28e-9 Rheumatoid arthritis; CRC cis rs644799 0.965 rs1944080 chr11:95503636 T/C cg03916912 chr11:95522834 CEP57;FAM76B 0.96 17.82 0.7 3.44e-50 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC trans rs4684776 0.500 rs35913374 chr3:11639274 T/C cg20302342 chr1:156215951 PAQR6 -0.48 -6.3 -0.33 9.8e-10 Small vessel stroke; CRC cis rs62064224 0.560 rs12162135 chr17:30805795 A/C cg21839984 chr17:30846986 MYO1D -0.35 -5.9 -0.31 9.24e-9 Schizophrenia; CRC cis rs801193 0.660 rs2659897 chr7:66187715 A/G cg18912574 chr7:65842487 NCRNA00174 -0.36 -6.14 -0.32 2.44e-9 Aortic root size; CRC cis rs1950626 0.532 rs61991120 chr14:101455222 G/A cg02351406 chr14:101447389 SNORD114-20;SNORD114-21 0.76 12.31 0.56 6.42e-29 Pelvic organ prolapse (moderate/severe); CRC cis rs13064411 0.696 rs9808893 chr3:113228444 G/A cg10517650 chr3:113235015 CCDC52 -0.41 -7.29 -0.37 2.4e-12 Response to simvastatin treatment (PCSK9 protein level change); CRC cis rs9303401 0.703 rs9910629 chr17:57210301 C/G cg02118635 chr17:56770003 RAD51C;TEX14 0.46 7.06 0.36 1.01e-11 Cognitive test performance; CRC cis rs9467711 0.606 rs9379900 chr6:26603811 A/C cg12315302 chr6:26189340 HIST1H4D 0.81 6.23 0.32 1.45e-9 Autism spectrum disorder or schizophrenia; CRC trans rs2018683 1.000 rs160837 chr7:29012732 C/G cg19402173 chr7:128379420 CALU -0.59 -9.24 -0.45 3.11e-18 Response to irinotecan and platinum-based chemotherapy in non-small-cell lung cancer; CRC cis rs798766 0.909 rs28521716 chr4:1745751 A/G cg05874882 chr4:1763078 NA -0.4 -7.22 -0.37 3.57e-12 Bladder cancer;Urinary bladder cancer; CRC cis rs595982 0.527 rs73061658 chr19:49372376 G/C cg21252483 chr19:49399788 TULP2 -0.37 -5.9 -0.31 8.91e-9 Red cell distribution width; CRC cis rs11229555 0.645 rs34794607 chr11:58188401 A/T cg15696309 chr11:58395628 NA -0.9 -11.45 -0.53 8.8e-26 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; CRC trans rs12406019 0.510 rs2025614 chr1:78618151 G/A cg20826526 chr3:156266748 SSR3 -0.49 -7.32 -0.37 1.95e-12 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs16852403 0.548 rs316280 chr1:178158085 C/T cg00404053 chr1:178313656 RASAL2 0.5 6.51 0.34 2.77e-10 Childhood ear infection; CRC cis rs6667605 0.506 rs10797440 chr1:2541269 A/G cg18854424 chr1:2615690 NA 0.49 9.89 0.48 2.26e-20 Inflammatory bowel disease;Ulcerative colitis; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg12416259 chr10:60028969 CISD1;IPMK 0.39 6.22 0.32 1.55e-9 Liver disease severity in Alagille syndrome; CRC cis rs654950 0.901 rs1885654 chr1:42007188 C/A cg06885757 chr1:42089581 HIVEP3 -0.51 -8.49 -0.42 7.27e-16 Airway imaging phenotypes; CRC cis rs7074356 0.831 rs12764048 chr10:82148963 A/G cg05935833 chr10:81318306 SFTPA2 -0.58 -7.06 -0.36 9.74e-12 Borderline personality disorder; CRC cis rs7692995 1.000 rs1585334 chr4:18018944 C/T cg08925142 chr4:18023851 LCORL -0.51 -5.81 -0.3 1.5e-8 Height; CRC cis rs7312774 0.618 rs61061573 chr12:107372758 T/C cg16260113 chr12:107380972 MTERFD3 1.01 9.38 0.46 1.09e-18 Severe influenza A (H1N1) infection; CRC cis rs4853012 0.838 rs6715351 chr2:74346119 G/A cg19729930 chr2:74357872 NA 0.61 9.43 0.46 7.73e-19 Gestational age at birth (maternal effect); CRC cis rs932541 1.000 rs6111155 chr20:16456461 C/A cg17003395 chr20:16555519 KIF16B 0.42 5.75 0.3 2.02e-8 Intelligence; CRC cis rs3751196 0.808 rs60378307 chr12:104206707 A/G cg02344784 chr12:104178138 NT5DC3 0.7 7.1 0.36 7.96e-12 Sense of smell; CRC cis rs889398 0.594 rs2133799 chr16:69913026 C/T cg00738113 chr16:70207722 CLEC18C -0.34 -5.92 -0.31 7.97e-9 Body mass index; CRC trans rs6940638 0.956 rs12199218 chr6:27025281 T/C cg06606381 chr12:133084897 FBRSL1 -0.6 -6.59 -0.34 1.72e-10 Intelligence (multi-trait analysis); CRC cis rs10256972 0.567 rs7782651 chr7:1159895 T/G cg18402987 chr7:1209562 NA 0.5 7.22 0.37 3.56e-12 Longevity;Endometriosis; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg10140087 chr19:42746897 GSK3A 0.46 6.57 0.34 1.91e-10 Intelligence (multi-trait analysis); CRC trans rs6550704 0.687 rs9865314 chr3:22634337 A/G cg16369786 chr1:63153804 DOCK7 -0.41 -6.07 -0.32 3.53e-9 Daytime sleep phenotypes; CRC cis rs644148 0.836 rs2571110 chr19:45000712 T/C cg15540054 chr19:45004280 ZNF180 -0.59 -8.24 -0.41 4.27e-15 Personality dimensions; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg21302420 chr1:112162376 RAP1A 0.37 6.03 0.32 4.31e-9 Liver disease severity in Alagille syndrome; CRC cis rs6570726 0.818 rs437147 chr6:145875423 A/T cg23711669 chr6:146136114 FBXO30 0.77 13.41 0.59 5.19e-33 Lobe attachment (rater-scored or self-reported); CRC cis rs6952808 1.000 rs4449693 chr7:1884630 G/C cg02951883 chr7:2050386 MAD1L1 -0.71 -11.24 -0.53 4.91e-25 Bipolar disorder and schizophrenia; CRC cis rs11123170 0.543 rs4849178 chr2:113982608 C/T cg12889195 chr2:113992843 PAX8;LOC440839;LOC654433 0.51 5.97 0.31 6.25e-9 Renal function-related traits (BUN); CRC cis rs10504229 1.000 rs77857677 chr8:58170131 G/A cg02290350 chr8:58132656 NA -0.42 -5.96 -0.31 6.62e-9 Developmental language disorder (linguistic errors); CRC cis rs13191362 0.935 rs13205279 chr6:162945030 C/T cg06582575 chr6:163149167 PACRG;PARK2 0.77 9.25 0.45 3.03e-18 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs10256972 0.553 rs4236381 chr7:1165723 A/C cg22907277 chr7:1156413 C7orf50 0.74 11.49 0.54 6.37e-26 Longevity;Endometriosis; CRC cis rs9914988 0.943 rs2043031 chr17:27085564 A/G cg12682573 chr17:27188876 MIR451;MIR144 0.58 8.02 0.4 1.88e-14 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs45509595 0.822 rs200484 chr6:27775674 A/G cg23259851 chr6:27775964 HIST1H2AI;HIST1H2BL 0.71 5.96 0.31 6.39e-9 Breast cancer; CRC cis rs4843747 0.671 rs72818576 chr16:88111019 C/G cg03395651 chr16:88107091 BANP 0.57 7.8 0.39 8.39e-14 Menopause (age at onset); CRC cis rs5758659 0.504 rs133367 chr22:42463366 A/G cg04733989 chr22:42467013 NAGA -0.49 -7.52 -0.38 5.24e-13 Cognitive function; CRC cis rs8078723 0.714 rs3785550 chr17:38149727 C/T cg17467752 chr17:38218738 THRA -0.58 -9.15 -0.45 6.16e-18 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg14021555 chr22:43485536 TTLL1 -0.51 -6.17 -0.32 1.98e-9 Diisocyanate-induced asthma; CRC cis rs12410462 0.582 rs12408978 chr1:227596235 A/T cg23173402 chr1:227635558 NA -0.71 -7.77 -0.39 1.04e-13 Major depressive disorder; CRC cis rs45509595 0.841 rs200485 chr6:27775697 G/C cg26587870 chr6:27730563 NA -0.67 -6.81 -0.35 4.76e-11 Breast cancer; CRC cis rs6952808 0.771 rs10275045 chr7:1920826 C/T cg02951883 chr7:2050386 MAD1L1 -0.62 -10.37 -0.5 5.67e-22 Bipolar disorder and schizophrenia; CRC cis rs116095464 0.558 rs2288458 chr5:231260 C/T cg22857025 chr5:266934 NA -1.21 -16.57 -0.67 2.78e-45 Breast cancer; CRC cis rs10540 1.000 rs61876334 chr11:487201 T/C cg03576123 chr11:487126 PTDSS2 -1.02 -10.25 -0.49 1.4e-21 Body mass index; CRC trans rs2840044 1.000 rs9913003 chr17:33893904 C/A cg19694781 chr19:47549865 TMEM160 0.44 6.96 0.36 1.87e-11 Response to radiotherapy in cancer (late toxicity); CRC cis rs172166 0.694 rs9295760 chr6:28147385 G/A cg20615401 chr6:28092323 ZSCAN16 0.44 5.76 0.3 1.88e-8 Cardiac Troponin-T levels; CRC cis rs7659604 0.689 rs4283687 chr4:122663460 A/G cg19748678 chr4:122722346 EXOSC9 0.48 6.72 0.35 8.08e-11 Type 2 diabetes; CRC cis rs73206853 0.841 rs56251637 chr12:110833869 T/G cg12870014 chr12:110450643 ANKRD13A 0.78 8.56 0.43 4.41e-16 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC trans rs3733585 0.699 rs28610447 chr4:9971517 T/C cg26043149 chr18:55253948 FECH -0.49 -7.47 -0.38 7.25e-13 Cleft plate (environmental tobacco smoke interaction); CRC trans rs9354654 0.826 rs1514351 chr6:68694074 T/C cg06657852 chr16:86786582 NA 0.41 6.01 0.31 4.89e-9 Classic bladder exstrophy; CRC cis rs4908768 0.501 rs6577494 chr1:8576925 C/T cg20416874 chr1:8611966 RERE -0.46 -6.57 -0.34 1.95e-10 Neuroticism (multi-trait analysis);Subjective well-being (multi-trait analysis); CRC cis rs6912958 0.559 rs242281 chr6:88048916 A/C cg12350822 chr6:88032061 C6orf162;GJB7 0.46 9.25 0.45 2.94e-18 Monocyte percentage of white cells; CRC cis rs854765 0.547 rs4368210 chr17:17896090 A/G cg07919128 chr17:18022025 MYO15A 0.36 5.74 0.3 2.19e-8 Total body bone mineral density; CRC trans rs7395662 0.553 rs4882155 chr11:48705801 T/C cg00717180 chr2:96193071 NA -0.38 -6.25 -0.33 1.27e-9 HDL cholesterol; CRC cis rs709400 0.663 rs72710714 chr14:103981849 T/G cg01849466 chr14:104193079 ZFYVE21 0.4 5.61 0.3 4.41e-8 Body mass index; CRC cis rs2243480 1.000 rs6959002 chr7:65650496 A/G cg18252515 chr7:66147081 NA 1.23 14.37 0.62 1.07e-36 Diabetic kidney disease; CRC cis rs875971 1.000 rs1167411 chr7:65539264 C/G cg12463550 chr7:65579703 CRCP -0.49 -6.91 -0.36 2.48e-11 Aortic root size; CRC cis rs938554 0.736 rs11734219 chr4:9977154 C/T cg11266682 chr4:10021025 SLC2A9 0.35 5.64 0.3 3.62e-8 Blood metabolite levels; CRC cis rs2075165 0.901 rs949464 chr1:156272271 C/T cg20302342 chr1:156215951 PAQR6 0.37 7.24 0.37 3.28e-12 Tonsillectomy; CRC cis rs7833986 0.501 rs72653921 chr8:56897157 T/C cg23139584 chr8:56987506 RPS20;SNORD54 0.79 11.35 0.53 2e-25 Height; CRC cis rs883565 0.740 rs11925218 chr3:39081171 C/A cg01426195 chr3:39028469 NA -0.53 -8.54 -0.43 4.97e-16 Handedness; CRC cis rs597539 0.652 rs579136 chr11:68637476 C/G cg06028808 chr11:68637592 NA 0.41 6.67 0.35 1.07e-10 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs12541635 0.677 rs11781234 chr8:107012342 G/T cg10147462 chr8:107024639 NA 0.57 9.97 0.48 1.29e-20 Age of smoking initiation; CRC cis rs68170813 0.559 rs12537733 chr7:106965447 A/T cg02696742 chr7:106810147 HBP1 -0.61 -6.96 -0.36 1.91e-11 Coronary artery disease; CRC cis rs35146811 0.700 rs858513 chr7:99825558 G/A cg13334819 chr7:99746414 C7orf59 0.56 7.27 0.37 2.61e-12 Coronary artery disease; CRC cis rs9733 0.596 rs12086630 chr1:150650955 T/C cg10589385 chr1:150898437 SETDB1 0.28 5.98 0.31 5.86e-9 Tonsillectomy; CRC cis rs875971 0.545 rs73376394 chr7:65637681 C/T cg18876405 chr7:65276391 NA 0.4 5.67 0.3 3.2e-8 Aortic root size; CRC cis rs13191362 0.507 rs2510207 chr6:163086592 T/C cg21926612 chr6:163149169 PACRG;PARK2 -0.6 -9.26 -0.45 2.72e-18 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs7659604 0.582 rs3217780 chr4:122737278 T/C cg20573242 chr4:122745356 CCNA2 0.57 8.47 0.42 8.51e-16 Type 2 diabetes; CRC cis rs9393692 0.627 rs1059486 chr6:26200083 A/G cg00631329 chr6:26305371 NA -0.57 -10.39 -0.5 4.84e-22 Educational attainment; CRC cis rs526631 0.564 rs10896051 chr11:65578759 C/T cg04055107 chr11:65626734 MUS81;CFL1 -0.42 -5.93 -0.31 7.84e-9 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; CRC cis rs4919694 1.000 rs111622998 chr10:104953021 C/A cg04362960 chr10:104952993 NT5C2 1.15 10.28 0.49 1.08e-21 Arsenic metabolism; CRC cis rs7809950 0.906 rs62483723 chr7:107186358 A/C cg23024343 chr7:107201750 COG5 -0.61 -8.69 -0.43 1.69e-16 Coronary artery disease; CRC cis rs8060686 0.591 rs255054 chr16:68017356 A/G cg08314208 chr16:67682810 RLTPR -0.66 -7.0 -0.36 1.44e-11 HDL cholesterol;Metabolic syndrome; CRC cis rs11098499 0.863 rs13136462 chr4:120543173 C/T cg09307838 chr4:120376055 NA 0.71 10.47 0.5 2.45e-22 Corneal astigmatism; CRC cis rs4481887 0.893 rs4423045 chr1:248479495 T/C cg00666640 chr1:248458726 OR2T12 0.46 7.92 0.4 3.72e-14 Common traits (Other); CRC cis rs950169 0.580 rs11633762 chr15:85187152 T/C cg17507749 chr15:85114479 UBE2QP1 0.66 9.38 0.46 1.14e-18 Schizophrenia; CRC cis rs13191362 0.507 rs2803051 chr6:163034979 G/A cg06582575 chr6:163149167 PACRG;PARK2 -0.55 -8.63 -0.43 2.69e-16 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs1707322 0.656 rs3014210 chr1:46066608 A/G cg06784218 chr1:46089804 CCDC17 -0.63 -11.4 -0.53 1.35e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg17497049 chr19:56110871 FIZ1;ZNF524 0.43 6.28 0.33 1.08e-9 Intelligence (multi-trait analysis); CRC cis rs977987 0.843 rs4146810 chr16:75415831 A/G cg03315344 chr16:75512273 CHST6 0.5 8.54 0.43 5.03e-16 Dupuytren's disease; CRC cis rs7945705 0.967 rs7943377 chr11:8848700 C/T cg14711859 chr11:8959438 ASCL3 -0.41 -6.53 -0.34 2.48e-10 Hemoglobin concentration; CRC cis rs9303280 0.901 rs12950743 chr17:38049233 T/C cg11212589 chr17:38028394 ZPBP2 0.48 8.89 0.44 4.21e-17 Self-reported allergy; CRC cis rs13108904 0.870 rs4974545 chr4:1271923 C/T cg21620606 chr4:1342894 KIAA1530 0.39 6.53 0.34 2.46e-10 Obesity-related traits; CRC cis rs4711336 1.000 rs11759396 chr6:33656654 C/G cg14003231 chr6:33640908 ITPR3 0.51 8.19 0.41 5.69e-15 Height; CRC cis rs7772486 0.754 rs4896832 chr6:145964151 G/A cg23711669 chr6:146136114 FBXO30 0.74 12.69 0.57 2.68e-30 Lobe attachment (rater-scored or self-reported); CRC cis rs2153535 0.580 rs7767926 chr6:8453557 A/G cg07606381 chr6:8435919 SLC35B3 0.68 10.87 0.51 1.01e-23 Motion sickness; CRC cis rs2019137 0.539 rs11123170 chr2:113978940 C/G cg23564664 chr2:113997917 PAX8;LOC654433;LOC440839 -0.37 -5.93 -0.31 7.66e-9 Lymphocyte counts; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg05491346 chr10:127512596 BCCIP;UROS 0.44 5.99 0.31 5.37e-9 Response to antipsychotic treatment; CRC cis rs6456156 0.692 rs9457270 chr6:167512928 A/G cg07741184 chr6:167504864 NA 0.5 8.45 0.42 9.4e-16 Primary biliary cholangitis; CRC cis rs7843479 0.524 rs1031884 chr8:21788984 C/T cg17168535 chr8:21777572 XPO7 0.66 11.06 0.52 2.17e-24 Mean corpuscular volume; CRC cis rs7512552 0.780 rs55823828 chr1:150467296 G/C cg15654264 chr1:150340011 RPRD2 0.6 8.38 0.42 1.56e-15 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); CRC cis rs9788333 0.707 rs12584557 chr13:21886171 C/A cg23743428 chr13:21893420 NA -0.44 -8.61 -0.43 3.18e-16 Thiazide-induced adverse metabolic effects in hypertensive patients; CRC cis rs875971 0.545 rs73148639 chr7:65855329 A/T cg03233332 chr7:66118400 NA -0.45 -6.26 -0.33 1.21e-9 Aortic root size; CRC cis rs9914988 0.943 rs2043032 chr17:27136692 A/G cg12682573 chr17:27188876 MIR451;MIR144 0.57 7.01 0.36 1.32e-11 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs344364 0.511 rs1657144 chr16:1963989 C/A cg09830162 chr16:1889614 FAHD1;C16orf73 -0.68 -8.14 -0.41 8.09e-15 Glomerular filtration rate in chronic kidney disease; CRC cis rs9868809 0.772 rs13070798 chr3:48705934 C/T cg00383909 chr3:49044727 WDR6 -0.57 -5.9 -0.31 9.05e-9 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; CRC cis rs9372498 0.572 rs56082110 chr6:118909480 A/G cg22561889 chr6:118971681 C6orf204 0.47 5.9 0.31 8.96e-9 Diastolic blood pressure; CRC cis rs4664293 0.625 rs34573069 chr2:160500072 T/A cg08347373 chr2:160653686 CD302 0.39 6.68 0.35 1.03e-10 Monocyte percentage of white cells; CRC cis rs10927875 0.518 rs945416 chr1:16344402 G/A cg24140574 chr1:16342155 HSPB7 0.47 6.67 0.35 1.1e-10 Dilated cardiomyopathy; CRC cis rs1707322 1.000 rs10789486 chr1:46408667 A/G cg06784218 chr1:46089804 CCDC17 0.52 9.22 0.45 3.59e-18 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs6502050 0.799 rs8082355 chr17:80120316 A/G cg25804541 chr17:80189381 SLC16A3 -0.31 -5.95 -0.31 6.84e-9 Life satisfaction; CRC cis rs6582630 0.537 rs11520294 chr12:38402705 C/A cg26384229 chr12:38710491 ALG10B 0.69 9.19 0.45 4.52e-18 Drug-induced liver injury (flucloxacillin); CRC cis rs6912958 0.781 rs1051148 chr6:88221892 T/G cg08069147 chr6:88032118 GJB7;C6orf162 -0.54 -8.13 -0.41 8.58e-15 Monocyte percentage of white cells; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg13834670 chr9:129677390 RALGPS1 0.37 6.5 0.34 3e-10 Liver disease severity in Alagille syndrome; CRC cis rs9527 0.590 rs7074395 chr10:104844928 A/C cg15744005 chr10:104629667 AS3MT 0.3 6.06 0.32 3.82e-9 Arsenic metabolism; CRC trans rs9929218 0.529 rs2296404 chr16:68729525 C/T cg04657470 chr2:198365150 HSPE1;HSPD1 1.04 21.01 0.76 9.79e-63 Colorectal cancer; CRC cis rs7799006 0.527 rs3779009 chr7:2203692 G/C cg02951883 chr7:2050386 MAD1L1 -0.54 -7.83 -0.4 6.65e-14 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs763121 0.853 rs5757181 chr22:39013522 G/A cg06544989 chr22:39130855 UNC84B 0.44 6.45 0.34 4.01e-10 Menopause (age at onset); CRC cis rs4654899 0.828 rs6668591 chr1:21066557 A/G cg02927042 chr1:21476669 EIF4G3 -0.44 -6.84 -0.35 3.88e-11 Superior frontal gyrus grey matter volume; CRC cis rs860295 0.702 rs2048431 chr1:155618630 G/A cg02153340 chr1:155202674 NA -0.54 -6.54 -0.34 2.38e-10 Body mass index; CRC cis rs9467773 0.836 rs1624440 chr6:26433329 G/A cg09904177 chr6:26538194 HMGN4 -0.67 -9.86 -0.48 2.93e-20 Intelligence (multi-trait analysis); CRC cis rs12545109 0.879 rs1513317 chr8:57372966 C/G cg09654669 chr8:57350985 NA -0.44 -5.86 -0.31 1.12e-8 Obesity-related traits; CRC cis rs703842 0.560 rs11533604 chr12:58047713 G/A cg18357645 chr12:58087776 OS9 -0.52 -6.15 -0.32 2.2e-9 Multiple sclerosis; CRC cis rs9549328 0.670 rs3011475 chr13:113616866 T/C cg17524180 chr13:113633600 MCF2L 0.52 9.32 0.46 1.71e-18 Systolic blood pressure; CRC cis rs4478137 0.931 rs7687423 chr4:164250797 C/T cg06758707 chr4:164254230 NPY1R -0.36 -5.63 -0.3 3.87e-8 Subjective well-being (multi-trait analysis);Subjective well-being; CRC cis rs9788333 0.888 rs35880230 chr13:21885972 A/G cg25811766 chr13:21894605 NA 0.61 9.06 0.45 1.18e-17 Thiazide-induced adverse metabolic effects in hypertensive patients; CRC cis rs875971 0.798 rs7789615 chr7:65878661 A/G cg18876405 chr7:65276391 NA 0.54 8.69 0.43 1.77e-16 Aortic root size; CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg25789201 chr7:72395803 POM121 -0.51 -6.09 -0.32 3.09e-9 Diisocyanate-induced asthma; CRC cis rs1552244 0.882 rs55808392 chr3:10054681 C/T cg13047869 chr3:10149882 C3orf24 0.52 6.87 0.35 3.26e-11 Alzheimer's disease; CRC cis rs3741404 0.895 rs2429455 chr11:63995302 C/G cg05016508 chr11:63871570 FLRT1;MACROD1 0.41 6.34 0.33 7.4e-10 Platelet count; CRC cis rs2278034 0.502 rs3747672 chr3:195612034 T/C cg00031303 chr3:195681400 NA 0.45 6.23 0.32 1.41e-9 Bronchopulmonary dysplasia; CRC cis rs7725052 0.581 rs10036578 chr5:40451057 C/A cg09067459 chr5:40385259 NA -0.4 -6.64 -0.34 1.3100000000000001e-10 Pediatric autoimmune diseases; CRC cis rs1552244 1.000 rs6772315 chr3:10113644 G/A cg16606324 chr3:10149918 C3orf24 0.71 9.58 0.47 2.51e-19 Alzheimer's disease; CRC cis rs3617 0.652 rs7630552 chr3:52891570 G/C cg15147215 chr3:52552868 STAB1 0.53 9.12 0.45 7.54e-18 Red blood cell count;Autism spectrum disorder or schizophrenia; CRC cis rs7264396 0.563 rs2425117 chr20:34323776 C/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.5 -6.7 -0.35 9.11e-11 Total cholesterol levels; CRC cis rs3858526 0.514 rs4595572 chr11:5864045 T/G cg25319279 chr11:5960081 NA -0.38 -6.51 -0.34 2.83e-10 DNA methylation (variation); CRC cis rs8060686 0.920 rs73593810 chr16:67866783 C/T cg26727032 chr16:67993705 SLC12A4 -0.58 -7.06 -0.36 9.84e-12 HDL cholesterol;Metabolic syndrome; CRC cis rs780096 0.546 rs715326 chr2:27725761 A/G cg02592271 chr2:27665507 KRTCAP3 0.26 5.82 0.31 1.37e-8 Total body bone mineral density; CRC trans rs2055729 0.677 rs10104353 chr8:9740358 G/C cg06636001 chr8:8085503 FLJ10661 -0.49 -6.33 -0.33 8.13e-10 Multiple myeloma (hyperdiploidy); CRC cis rs2204008 0.623 rs1663281 chr12:38120936 A/G cg26384229 chr12:38710491 ALG10B -0.56 -8.38 -0.42 1.53e-15 Bladder cancer; CRC cis rs6502050 0.799 rs12940433 chr17:80120826 C/T cg09264619 chr17:80180166 NA -0.35 -5.93 -0.31 7.47e-9 Life satisfaction; CRC cis rs425277 0.606 rs2257684 chr1:2077872 A/G cg24578937 chr1:2090814 PRKCZ 0.43 7.65 0.39 2.18e-13 Height; CRC cis rs11190604 1.000 rs7080356 chr10:102266735 A/C cg16342193 chr10:102329863 NA -0.34 -5.76 -0.3 1.93e-8 Palmitoleic acid (16:1n-7) levels; CRC cis rs7552404 0.727 rs2172507 chr1:76331320 A/G cg10523679 chr1:76189770 ACADM -0.67 -8.86 -0.44 5.1e-17 Blood metabolite levels;Acylcarnitine levels; CRC cis rs877282 0.891 rs10904557 chr10:797490 C/T cg06581033 chr10:766294 NA 0.5 5.72 0.3 2.42e-8 Uric acid levels; CRC cis rs12477438 0.520 rs8179690 chr2:99795300 A/T cg26064155 chr2:99771622 LIPT1;TSGA10 -0.87 -16.05 -0.66 3.12e-43 Chronic sinus infection; CRC cis rs7224685 0.501 rs781853 chr17:3953083 T/C cg10724054 chr17:3904396 NA -0.46 -7.44 -0.38 8.65e-13 Type 2 diabetes; CRC cis rs11148252 0.904 rs3892337 chr13:53029485 C/G cg12458913 chr13:53173898 NA 0.58 9.23 0.45 3.32e-18 Lewy body disease; CRC cis rs514406 0.830 rs533935 chr1:53308807 T/C cg25767906 chr1:53392781 SCP2 -0.43 -6.94 -0.36 2.11e-11 Monocyte count; CRC cis rs4731207 0.596 rs2170354 chr7:124665919 G/A cg23710748 chr7:124431027 NA -0.38 -6.0 -0.31 5.29e-9 Cutaneous malignant melanoma; CRC cis rs11628318 0.614 rs942022 chr14:103108842 C/T cg23071808 chr14:103021642 NA -0.63 -7.34 -0.37 1.74e-12 Platelet count; CRC cis rs7493 1.000 rs1034809 chr7:95051652 G/A cg04155289 chr7:94953770 PON1 -0.62 -7.71 -0.39 1.55e-13 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs68170813 0.559 rs3815148 chr7:106938420 G/T cg02696742 chr7:106810147 HBP1 0.54 6.39 0.33 5.63e-10 Coronary artery disease; CRC trans rs2303319 0.504 rs12467625 chr2:162603387 C/A cg18122310 chr12:50236657 BCDIN3D -0.73 -6.35 -0.33 7.23e-10 Cognitive function; CRC cis rs7632954 1.000 rs7632954 chr3:8527882 C/T cg03495237 chr3:8533978 NA 0.33 5.84 0.31 1.23e-8 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs7399018 0.739 rs6580811 chr12:51612501 T/C cg10377582 chr12:51612794 POU6F1 -0.3 -5.77 -0.3 1.8e-8 Cisplatin-induced ototoxicity; CRC cis rs713477 0.967 rs11158039 chr14:55906696 A/T cg13175173 chr14:55914753 NA -0.52 -9.84 -0.48 3.33e-20 Pediatric bone mineral content (femoral neck); CRC cis rs2530545 0.619 rs6955781 chr7:34662349 C/T cg14401837 chr7:34697493 NPSR1 0.42 6.27 0.33 1.14e-9 IgG glycosylation; CRC cis rs1799949 0.929 rs12937015 chr17:41307473 A/C cg19454999 chr17:41278357 BRCA1;NBR2 0.55 8.69 0.43 1.69e-16 Menopause (age at onset); CRC cis rs798554 0.721 rs2527680 chr7:2892361 C/T cg13628971 chr7:2884303 GNA12 0.6 8.03 0.4 1.76e-14 Height; CRC cis rs10416265 0.502 rs7245411 chr19:33543029 A/T cg27124370 chr19:33622961 WDR88 0.49 7.26 0.37 2.87e-12 Bone properties (heel); CRC cis rs853679 0.517 rs3734573 chr6:28059437 T/C cg06470822 chr6:28175283 NA 1.0 13.31 0.59 1.27e-32 Depression; CRC cis rs3015497 0.789 rs11621971 chr14:51124527 C/T cg09863266 chr14:51125203 SAV1 0.33 6.21 0.32 1.59e-9 Mean platelet volume; CRC cis rs6582630 0.622 rs11831595 chr12:38511489 C/A cg13010199 chr12:38710504 ALG10B -0.41 -5.95 -0.31 6.8e-9 Drug-induced liver injury (flucloxacillin); CRC cis rs2011503 1.000 rs2916075 chr19:19530590 G/C cg11584989 chr19:19387371 SF4 0.57 6.42 0.33 4.71e-10 Bipolar disorder; CRC cis rs12188164 0.610 rs6555242 chr5:416546 A/C cg17553881 chr5:443987 EXOC3;C5orf55 -0.32 -6.93 -0.36 2.29e-11 Cystic fibrosis severity; CRC cis rs13108904 0.967 rs1732107 chr4:1276758 G/A cg00684032 chr4:1343700 KIAA1530 -0.41 -6.05 -0.32 4.03e-9 Obesity-related traits; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg23916948 chr1:155108399 RAG1AP1 0.44 6.47 0.34 3.63e-10 Intelligence (multi-trait analysis); CRC cis rs8177253 0.829 rs9882812 chr3:133506127 A/G cg12373951 chr3:133503437 NA 0.26 6.56 0.34 2.05e-10 Iron status biomarkers; CRC cis rs243505 0.667 rs10249029 chr7:148576042 C/T cg09806900 chr7:148480153 CUL1 0.45 6.4 0.33 5.46e-10 Inflammatory bowel disease;Crohn's disease; CRC cis rs12497850 0.931 rs7628719 chr3:48995487 C/T cg07636037 chr3:49044803 WDR6 1.03 18.62 0.72 2.28e-53 Parkinson's disease; CRC cis rs3540 0.960 rs8030722 chr15:90974920 G/A cg04176472 chr15:90893244 GABARAPL3 0.36 6.32 0.33 8.45e-10 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; CRC cis rs7412746 0.658 rs12410394 chr1:150860186 G/A cg15448220 chr1:150897856 SETDB1 0.56 8.02 0.4 1.87e-14 Melanoma; CRC cis rs1707322 1.000 rs6672115 chr1:46272879 T/C cg03146154 chr1:46216737 IPP 0.6 8.5 0.42 6.87e-16 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs10870270 0.957 rs7074604 chr10:133740373 G/C cg17892150 chr10:133769511 PPP2R2D -0.71 -10.86 -0.51 1.11e-23 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; CRC cis rs6951245 1.000 rs75016635 chr7:1094121 G/A cg26224354 chr7:1096374 C7orf50;GPR146 -0.94 -12.22 -0.56 1.4e-28 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs4665809 0.590 rs62128457 chr2:26467347 C/A cg26119090 chr2:26468346 HADHA;HADHB 1.06 15.5 0.65 4.69e-41 Gut microbiome composition (summer); CRC cis rs1448094 0.511 rs17279261 chr12:86162714 C/T cg25456477 chr12:86230367 RASSF9 0.39 6.44 0.33 4.26e-10 Major depressive disorder; CRC trans rs1814175 0.565 rs4881721 chr11:49761851 G/A cg21153622 chr11:89784906 NA -0.42 -6.9 -0.36 2.6e-11 Height; CRC cis rs6879260 1.000 rs7730585 chr5:179733440 T/C cg23248424 chr5:179741104 GFPT2 -0.61 -9.31 -0.46 1.92e-18 Height; CRC cis rs35883536 1.000 rs1577508 chr1:101089289 T/C cg14515779 chr1:101123966 NA -0.43 -8.39 -0.42 1.49e-15 Monocyte count; CRC cis rs11212617 0.967 rs662218 chr11:108194528 C/A cg01991180 chr11:108092276 ATM;NPAT 0.4 5.65 0.3 3.47e-8 Response to metformin in type 2 diabetes (glycemic); CRC cis rs4713118 0.513 rs149897 chr6:28006650 A/G cg12273811 chr6:28175739 NA 0.57 8.34 0.42 2.14e-15 Parkinson's disease; CRC cis rs9287719 0.967 rs6735074 chr2:10734766 G/T cg00105475 chr2:10696890 NA -0.45 -7.28 -0.37 2.44e-12 Prostate cancer; CRC cis rs6429082 0.783 rs390539 chr1:235679690 A/C cg26050004 chr1:235667680 B3GALNT2 0.56 8.0 0.4 2.17e-14 Adiposity; CRC trans rs916888 0.610 rs199453 chr17:44800946 C/T cg10053473 chr17:62856997 LRRC37A3 -0.61 -8.3 -0.42 2.66e-15 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC trans rs6703335 0.870 rs10803142 chr1:243598234 A/G cg19566272 chr6:139695824 CITED2 0.44 6.21 0.32 1.63e-9 Schizophrenia;Schizophrenia, schizoaffective disorder or bipolar disorder; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg24293567 chr9:135754124 C9orf98;C9orf9 0.49 7.02 0.36 1.26e-11 Intelligence (multi-trait analysis); CRC cis rs7833986 0.501 rs17812659 chr8:56889862 A/G cg23139584 chr8:56987506 RPS20;SNORD54 0.77 9.97 0.48 1.21e-20 Height; CRC cis rs12950390 0.853 rs28589850 chr17:45855713 A/G cg24803719 chr17:45855879 NA -0.32 -6.97 -0.36 1.72e-11 IgG glycosylation; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg10512748 chr1:28844557 SNHG3-RCC1;RCC1 0.53 6.82 0.35 4.34e-11 Thyroid stimulating hormone; CRC cis rs9300255 0.569 rs1790115 chr12:123620270 C/G cg00376283 chr12:123451042 ABCB9 0.6 8.13 0.41 8.9e-15 Neutrophil percentage of white cells; CRC cis rs9914988 0.943 rs66588554 chr17:27141110 A/G cg20469991 chr17:27169893 C17orf63 -0.59 -7.18 -0.37 4.82e-12 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs9682041 0.935 rs11923053 chr3:170095281 T/C cg11886554 chr3:170076028 SKIL 0.74 8.28 0.42 3.17e-15 Glomerular filtration rate in non diabetics (creatinine);Glomerular filtration rate (creatinine); CRC cis rs1165205 0.558 rs531750 chr6:25882642 C/G cg03517284 chr6:25882590 NA -0.88 -13.88 -0.61 8.77e-35 Urate levels; CRC cis rs734999 0.545 rs10910106 chr1:2538886 G/T cg20673091 chr1:2541236 MMEL1 0.37 5.91 0.31 8.45e-9 Ulcerative colitis; CRC cis rs4722166 0.645 rs1404006 chr7:22795077 T/C cg05472934 chr7:22766657 IL6 0.66 10.75 0.51 2.73e-23 Lung cancer; CRC cis rs801193 0.548 rs2109297 chr7:66122384 G/A cg18252515 chr7:66147081 NA 0.44 6.2 0.32 1.72e-9 Aortic root size; CRC cis rs2635047 0.638 rs2571008 chr18:44649950 T/C cg19077165 chr18:44547161 KATNAL2 -0.43 -6.66 -0.34 1.17e-10 Educational attainment; CRC cis rs4654899 0.865 rs72988025 chr1:21351441 A/G cg05370193 chr1:21551575 ECE1 0.36 5.74 0.3 2.19e-8 Superior frontal gyrus grey matter volume; CRC cis rs12142240 0.698 rs45449893 chr1:46859024 A/G cg00530320 chr1:46809349 NSUN4 0.59 8.07 0.41 1.35e-14 Menopause (age at onset); CRC cis rs854765 0.964 rs854764 chr17:18011750 A/G cg24612305 chr17:17875800 TOM1L2;LRRC48 -0.61 -8.08 -0.41 1.25e-14 Total body bone mineral density; CRC cis rs7927771 0.864 rs2053979 chr11:47439444 A/G cg20307385 chr11:47447363 PSMC3 -0.61 -9.02 -0.45 1.58e-17 Subjective well-being; CRC cis rs6840360 0.593 rs7654294 chr4:152690975 T/C cg09659197 chr4:152720779 NA 0.41 8.62 0.43 2.82e-16 Intelligence (multi-trait analysis); CRC cis rs35883536 1.000 rs2297716 chr1:101092526 G/C cg14515779 chr1:101123966 NA -0.43 -8.39 -0.42 1.49e-15 Monocyte count; CRC cis rs6534441 0.857 rs7670240 chr4:125460187 T/G cg21609808 chr4:125404261 NA 0.38 5.75 0.3 2.07e-8 Major depressive disorder; CRC cis rs2799081 1 rs2799081 chr6:28270584 T/C cg21251018 chr6:28226885 NKAPL 0.49 7.75 0.39 1.13e-13 Myopia; CRC cis rs7918232 0.574 rs10458708 chr10:27455605 C/T cg14442939 chr10:27389572 ANKRD26 0.95 14.57 0.63 1.89e-37 Breast cancer; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg09400194 chr10:81107848 PPIF 0.45 6.28 0.33 1.1e-9 Response to antipsychotic treatment; CRC cis rs61160187 0.518 rs62372133 chr5:60202177 T/G cg16298547 chr5:60138761 ELOVL7 -0.28 -5.93 -0.31 7.59e-9 Educational attainment (years of education);Educational attainment (college completion); CRC cis rs7216064 1.000 rs8074078 chr17:65838743 A/C cg12091567 chr17:66097778 LOC651250 -0.63 -7.98 -0.4 2.4e-14 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CRC cis rs8180040 0.966 rs2101247 chr3:47494303 G/A cg02527881 chr3:46936655 PTH1R 0.38 7.06 0.36 9.69e-12 Colorectal cancer; CRC cis rs6831352 0.918 rs13127153 chr4:100058121 C/T cg13256891 chr4:100009986 ADH5 -0.65 -8.72 -0.43 1.42e-16 Alcohol dependence; CRC cis rs72945132 0.825 rs12287883 chr11:70122369 C/T cg00319359 chr11:70116639 PPFIA1 0.68 7.5 0.38 6.05e-13 Coronary artery disease; CRC trans rs10242455 0.571 rs56167514 chr7:99161347 A/G cg09045935 chr12:6379348 NA 1.06 8.41 0.42 1.29e-15 Blood metabolite levels; CRC trans rs7618501 0.521 rs6774354 chr3:49961780 G/A cg21659725 chr3:3221576 CRBN 0.47 6.84 0.35 3.98e-11 Intelligence (multi-trait analysis); CRC cis rs9517320 0.534 rs61971163 chr13:99188883 G/A cg07423050 chr13:99094983 FARP1 -0.54 -7.69 -0.39 1.76e-13 Longevity; CRC cis rs9462846 0.691 rs67059212 chr6:42913269 T/G cg02353165 chr6:42928485 GNMT 0.62 9.16 0.45 5.49e-18 Blood protein levels; CRC cis rs28386778 0.897 rs2665795 chr17:61925272 A/G cg11494091 chr17:61959527 GH2 -0.62 -10.67 -0.51 5.16e-23 Prudent dietary pattern; CRC cis rs10191773 0.535 rs72833432 chr2:113102746 T/C cg24977338 chr2:113188963 RGPD8;RGPD5 -0.62 -6.03 -0.32 4.5e-9 Yeast infection; CRC cis rs2439831 0.850 rs12441127 chr15:44021175 T/C cg02155558 chr15:43621948 ADAL;LCMT2 0.71 7.68 0.39 1.9e-13 Lung cancer in ever smokers; CRC cis rs243505 1.000 rs1019058 chr7:148424243 A/G cg09806900 chr7:148480153 CUL1 -0.44 -6.28 -0.33 1.04e-9 Inflammatory bowel disease;Crohn's disease; CRC cis rs6951245 1.000 rs113575110 chr7:1084394 G/A cg24642844 chr7:1081250 C7orf50 -0.79 -9.4 -0.46 9.42e-19 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs7312933 0.528 rs10880238 chr12:42489613 A/G cg01256987 chr12:42539512 GXYLT1 -0.62 -10.9 -0.52 7.76e-24 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CRC cis rs7811142 0.830 rs3087502 chr7:99955364 G/A cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.11 15.96 0.66 7.52e-43 Platelet count; CRC cis rs11098499 0.955 rs13129661 chr4:120152909 C/G cg24375607 chr4:120327624 NA 0.43 6.67 0.35 1.09e-10 Corneal astigmatism; CRC cis rs7937682 0.961 rs11601674 chr11:111634354 C/T cg19812747 chr11:111475976 SIK2 -0.5 -7.99 -0.4 2.23e-14 Primary sclerosing cholangitis; CRC cis rs7113874 0.589 rs10769910 chr11:8499406 T/C cg17679104 chr11:8615758 STK33 0.35 5.74 0.3 2.17e-8 Body mass index in physically active individuals;Body mass index (joint analysis main effects and physical activity interaction); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg00587304 chr3:172468157 NA 0.49 6.85 0.35 3.68e-11 Response to antipsychotic treatment; CRC cis rs2573652 0.698 rs12916269 chr15:100530216 A/T cg00587665 chr15:100533223 ADAMTS17 0.42 7.5 0.38 6.15e-13 Height; CRC cis rs262150 0.731 rs2657388 chr7:158763428 A/G cg19418458 chr7:158789849 NA 0.41 6.94 0.36 2.1e-11 Facial morphology (factor 20); CRC cis rs4242434 0.854 rs3064 chr8:22451688 C/G cg03733263 chr8:22462867 KIAA1967 -0.98 -18.76 -0.72 6.4e-54 Exploratory eye movement dysfunction in schizophrenia (cognitive search score); CRC cis rs7927771 0.864 rs2868459 chr11:47454972 C/G cg18512352 chr11:47633146 NA -0.4 -7.82 -0.4 7.23e-14 Subjective well-being; CRC cis rs9894429 0.752 rs7502883 chr17:79588557 T/C cg21984481 chr17:79567631 NPLOC4 -0.58 -11.19 -0.53 7.42e-25 Eye color traits; CRC cis rs28735056 1.000 rs56376220 chr18:77609462 C/T cg20368463 chr18:77673604 PQLC1 -0.54 -8.31 -0.42 2.46e-15 Schizophrenia; CRC cis rs116095464 0.558 rs10058428 chr5:235608 A/G cg22857025 chr5:266934 NA -1.25 -16.75 -0.68 5.7e-46 Breast cancer; CRC trans rs2228479 0.850 rs17233448 chr16:89816424 G/T cg24644049 chr4:85504048 CDS1 0.9 7.46 0.38 7.69e-13 Skin colour saturation; CRC cis rs7615952 0.576 rs12497295 chr3:125818650 G/A cg15145296 chr3:125709740 NA -0.57 -6.64 -0.34 1.29e-10 Blood pressure (smoking interaction); CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg21062897 chr14:50999680 MAP4K5;ATL1 0.37 6.13 0.32 2.51e-9 Obesity-related traits; CRC cis rs3824867 0.770 rs11820680 chr11:47452744 C/T cg05585544 chr11:47624801 NA 0.41 6.32 0.33 8.5e-10 Mean corpuscular hemoglobin; CRC cis rs7512552 0.839 rs12040949 chr1:150447462 C/T cg15654264 chr1:150340011 RPRD2 0.59 8.18 0.41 6.07e-15 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); CRC cis rs9796 0.621 rs28737302 chr15:41469943 G/A cg18705301 chr15:41695430 NDUFAF1 -0.42 -6.98 -0.36 1.64e-11 Menopause (age at onset); CRC cis rs9325144 0.600 rs10785615 chr12:38733627 G/C cg13010199 chr12:38710504 ALG10B 0.43 6.26 0.33 1.21e-9 Morning vs. evening chronotype; CRC cis rs4253772 0.591 rs12167567 chr22:46659942 G/C cg09491104 chr22:46646882 C22orf40 -0.48 -7.03 -0.36 1.19e-11 LDL cholesterol;Cholesterol, total; CRC cis rs9308731 0.623 rs6708784 chr2:111927379 A/G cg04202892 chr2:111875749 ACOXL 0.48 7.75 0.39 1.14e-13 Chronic lymphocytic leukemia; CRC cis rs3736485 0.837 rs4774593 chr15:51821845 A/G cg08986416 chr15:51914746 DMXL2 -0.49 -7.06 -0.36 9.93e-12 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC trans rs6928289 0.527 rs9494736 chr6:137673055 A/G cg24169820 chr12:121711996 CAMKK2 -0.41 -6.04 -0.32 4.24e-9 Thiazide-induced adverse metabolic effects in hypertensive patients; CRC cis rs9325144 0.560 rs7980358 chr12:38640396 C/G cg13010199 chr12:38710504 ALG10B 0.41 6.01 0.31 4.82e-9 Morning vs. evening chronotype; CRC trans rs1945213 0.694 rs7122627 chr11:55862565 A/G cg15704280 chr7:45808275 SEPT13 0.56 6.27 0.33 1.15e-9 Acute lymphoblastic leukemia (childhood); CRC cis rs6424115 1.000 rs12031592 chr1:24127864 A/C cg15997130 chr1:24165203 NA 0.69 10.73 0.51 3.09e-23 Immature fraction of reticulocytes; CRC cis rs4319547 0.656 rs9788145 chr12:122899522 C/T cg23029597 chr12:123009494 RSRC2 -0.57 -7.13 -0.37 6.41e-12 Body mass index; CRC cis rs743757 1.000 rs9835537 chr3:50464335 T/C cg08207895 chr3:50388901 TUSC4;CYB561D2 0.44 6.51 0.34 2.77e-10 Diastolic blood pressure; CRC cis rs1707322 0.721 rs4660883 chr1:46236098 C/T cg06784218 chr1:46089804 CCDC17 0.64 11.85 0.55 3.21e-27 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC trans rs9858542 1.000 rs9882740 chr3:49702484 T/C cg21659725 chr3:3221576 CRBN -0.69 -9.04 -0.45 1.36e-17 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs4969178 0.896 rs11077361 chr17:76397128 A/G cg05887092 chr17:76393375 PGS1 0.55 10.0 0.48 1e-20 HDL cholesterol levels; CRC cis rs7666738 0.753 rs28463863 chr4:98844444 T/C cg05340658 chr4:99064831 C4orf37 0.57 8.42 0.42 1.19e-15 Colonoscopy-negative controls vs population controls; CRC trans rs7618501 1.000 rs34451146 chr3:49813013 C/T cg21582582 chr3:182698605 DCUN1D1 0.56 8.34 0.42 2.09e-15 Intelligence (multi-trait analysis); CRC cis rs17152411 1.000 rs733402 chr10:126594152 T/C cg07906193 chr10:126599966 NA 0.58 6.52 0.34 2.69e-10 Height; CRC cis rs4555082 0.794 rs2735829 chr14:105708472 C/T cg13114125 chr14:105738426 BRF1 -0.79 -11.51 -0.54 5.54e-26 Mean platelet volume;Platelet distribution width; CRC trans rs7395662 0.864 rs12366262 chr11:48563472 T/A cg21153622 chr11:89784906 NA -0.47 -7.58 -0.39 3.59e-13 HDL cholesterol; CRC cis rs10883723 0.810 rs2296590 chr10:104262628 G/A cg04362960 chr10:104952993 NT5C2 -0.43 -6.1 -0.32 2.92e-9 Allergic disease (asthma, hay fever or eczema); CRC trans rs12599106 0.792 rs12597352 chr16:34638507 A/T cg01516881 chr6:292596 DUSP22 -0.55 -8.04 -0.41 1.63e-14 Menopause (age at onset); CRC cis rs28386778 0.829 rs1877317 chr17:61776479 T/C cg11494091 chr17:61959527 GH2 0.66 11.15 0.52 1.07e-24 Prudent dietary pattern; CRC cis rs7312933 1.000 rs7312933 chr12:42503467 C/T cg01256987 chr12:42539512 GXYLT1 0.39 5.94 0.31 7.43e-9 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CRC cis rs8067545 0.641 rs203462 chr17:19812541 T/C cg04132472 chr17:19861366 AKAP10 0.44 6.86 0.35 3.36e-11 Schizophrenia; CRC cis rs1448094 0.511 rs11117042 chr12:86207547 G/T cg25456477 chr12:86230367 RASSF9 0.35 6.21 0.32 1.62e-9 Major depressive disorder; CRC cis rs4731207 0.672 rs3213667 chr7:124480869 T/C cg23710748 chr7:124431027 NA 0.38 6.08 0.32 3.42e-9 Cutaneous malignant melanoma; CRC cis rs11098499 0.738 rs34566984 chr4:120361270 G/A cg24375607 chr4:120327624 NA 0.51 7.98 0.4 2.49e-14 Corneal astigmatism; CRC cis rs6604026 0.698 rs10874744 chr1:93306317 G/A cg17283838 chr1:93427260 FAM69A -0.47 -6.65 -0.34 1.24e-10 Multiple sclerosis; CRC cis rs3087591 0.960 rs1801052 chr17:29508775 C/T cg24425628 chr17:29625626 OMG;NF1 0.83 15.85 0.66 1.92e-42 Hip circumference; CRC cis rs9902453 0.740 rs2617867 chr17:28049399 C/T cg26525008 chr17:28256777 EFCAB5;SSH2 -0.71 -11.83 -0.55 3.79e-27 Coffee consumption (cups per day); CRC cis rs7580658 0.750 rs4497825 chr2:128061053 A/G cg09760422 chr2:128146352 NA -0.32 -6.17 -0.32 2.01e-9 Protein C levels; CRC cis rs2204008 0.837 rs11519926 chr12:38348992 G/A cg13010199 chr12:38710504 ALG10B 0.45 5.76 0.3 1.96e-8 Bladder cancer; CRC cis rs10504229 0.636 rs77290284 chr8:58055269 G/T cg24829409 chr8:58192753 C8orf71 -0.64 -7.96 -0.4 2.9e-14 Developmental language disorder (linguistic errors); CRC cis rs3785574 0.925 rs2727340 chr17:61970224 T/A cg22520471 chr17:61851767 DDX42;CCDC47 0.47 6.35 0.33 7.06e-10 Height; CRC trans rs9858542 0.953 rs11706370 chr3:49441091 G/A cg21665057 chr3:196295764 WDR53;FBXO45 -0.62 -8.52 -0.43 5.85e-16 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs1065852 0.526 rs7290907 chr22:42390209 G/A cg22189786 chr22:42395067 WBP2NL 0.44 6.45 0.34 4.01e-10 Response to serotonin reuptake inhibitors in major depressive disorder (plasma drug and metabolite levels); CRC cis rs7709909 0.720 rs408626 chr5:79951133 T/C cg24059623 chr5:79951536 MSH3;DHFR 0.43 7.09 0.36 8.24e-12 HDL cholesterol change in response to fenofibrate in statin-treated type 2 diabetes; CRC cis rs853679 0.517 rs9368550 chr6:28051803 T/A cg25164649 chr6:28176230 NA 0.73 9.18 0.45 4.85e-18 Depression; CRC cis rs2243480 1.000 rs465359 chr7:65558164 C/T cg12463550 chr7:65579703 CRCP 0.68 6.55 0.34 2.22e-10 Diabetic kidney disease; CRC trans rs2303319 0.504 rs16846026 chr2:162537691 T/C cg03757145 chr4:76555832 CDKL2 -0.66 -5.97 -0.31 5.99e-9 Cognitive function; CRC cis rs3736485 0.966 rs11070862 chr15:51902227 G/A cg08986416 chr15:51914746 DMXL2 -0.45 -6.53 -0.34 2.56e-10 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs9875589 0.509 rs28865280 chr3:14064958 C/T cg14375111 chr3:14165186 TMEM43;CHCHD4 0.42 6.36 0.33 6.93e-10 Ovarian reserve; CRC cis rs1552244 1.000 rs2272125 chr3:10138069 A/C cg02579736 chr3:10068473 FANCD2;CIDECP 0.92 12.65 0.57 3.8e-30 Alzheimer's disease; CRC cis rs597539 0.652 rs602364 chr11:68662167 C/T cg04772025 chr11:68637568 NA 0.48 7.38 0.38 1.32e-12 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs3749237 0.964 rs7431078 chr3:49808190 G/A cg03060546 chr3:49711283 APEH 0.51 7.7 0.39 1.61e-13 Resting heart rate; CRC cis rs4665809 0.590 rs35746418 chr2:26455002 C/G cg08067268 chr2:26466485 HADHB;HADHA 0.65 8.34 0.42 2e-15 Gut microbiome composition (summer); CRC trans rs6951245 1.000 rs11770909 chr7:1086716 G/A cg13565492 chr6:43139072 SRF -0.71 -7.1 -0.36 7.59e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg24674680 chr1:227174512 CABC1 0.4 7.21 0.37 3.89e-12 Liver disease severity in Alagille syndrome; CRC cis rs12956009 0.583 rs11082575 chr18:44905068 C/G cg20875182 chr18:44561130 TCEB3B;KATNAL2 -0.45 -6.17 -0.32 1.98e-9 Educational attainment (years of education); CRC cis rs1862618 0.853 rs3099459 chr5:56137170 G/C cg24531977 chr5:56204891 C5orf35 -0.82 -10.91 -0.52 7.64e-24 Initial pursuit acceleration; CRC cis rs11098499 0.909 rs78332141 chr4:120375782 C/T cg09307838 chr4:120376055 NA 0.73 11.05 0.52 2.35e-24 Corneal astigmatism; CRC cis rs9911578 1.000 rs2055779 chr17:57030561 A/G cg05425664 chr17:57184151 TRIM37 -0.5 -7.88 -0.4 4.85e-14 Intelligence (multi-trait analysis); CRC cis rs72634258 0.554 rs12741937 chr1:7897622 A/T cg26816564 chr1:7831052 VAMP3 0.94 9.94 0.48 1.61e-20 Inflammatory bowel disease; CRC cis rs7746199 0.668 rs7749305 chr6:27446566 T/C cg21204522 chr6:27730016 NA -0.67 -5.89 -0.31 9.79e-9 Gait speed in old age;Autism spectrum disorder or schizophrenia; CRC cis rs4900538 0.821 rs7012 chr14:102814945 C/T cg18135206 chr14:102964638 TECPR2 -0.98 -18.06 -0.71 3.87e-51 Mean corpuscular volume;Mean corpuscular hemoglobin; CRC cis rs12477438 0.748 rs7558239 chr2:99640581 G/C cg14399236 chr2:99771627 LIPT1;TSGA10 -0.74 -10.4 -0.5 4.36e-22 Chronic sinus infection; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg04478727 chr12:58166393 METTL1;FAM119B 0.4 6.11 0.32 2.81e-9 Intelligence (multi-trait analysis); CRC cis rs4665809 0.590 rs6730317 chr2:26419482 C/T cg08067268 chr2:26466485 HADHB;HADHA -0.67 -8.48 -0.42 7.53e-16 Gut microbiome composition (summer); CRC cis rs920590 0.721 rs67989257 chr8:19660278 G/A cg03894339 chr8:19674705 INTS10 0.43 5.87 0.31 1.05e-8 Acute lymphoblastic leukemia (childhood); CRC cis rs9914988 0.943 rs34693224 chr17:27079555 C/T cg20469991 chr17:27169893 C17orf63 -0.59 -7.19 -0.37 4.3e-12 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs12760731 0.565 rs12044522 chr1:178190180 G/T cg00404053 chr1:178313656 RASAL2 1.05 10.9 0.52 7.99e-24 Obesity-related traits; CRC cis rs7727544 0.606 rs200838 chr5:131710399 A/C cg11843238 chr5:131593191 PDLIM4 -0.31 -5.7 -0.3 2.64e-8 Blood metabolite levels; CRC cis rs877282 0.898 rs12358966 chr10:758703 A/G cg17470449 chr10:769945 NA 0.64 8.62 0.43 2.87e-16 Uric acid levels; CRC trans rs1455244 0.700 rs7229302 chr18:11508904 G/T cg00223186 chr1:180472200 ACBD6 0.42 6.28 0.33 1.04e-9 Schizophrenia; CRC cis rs801193 0.935 rs2659899 chr7:66186721 A/G cg18876405 chr7:65276391 NA 0.59 10.5 0.5 1.95e-22 Aortic root size; CRC cis rs769267 0.965 rs7254230 chr19:19434350 C/T cg01262667 chr19:19385393 TM6SF2 -0.37 -6.22 -0.32 1.51e-9 Tonsillectomy; CRC cis rs877282 0.853 rs7079299 chr10:756455 A/G cg17470449 chr10:769945 NA 0.61 7.96 0.4 2.78e-14 Uric acid levels; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg17554553 chr10:31321002 ZNF438 0.36 6.14 0.32 2.36e-9 Liver disease severity in Alagille syndrome; CRC cis rs780096 0.506 rs8395 chr2:27715207 T/A cg24768116 chr2:27665128 KRTCAP3 -0.34 -7.6 -0.39 3.09e-13 Total body bone mineral density; CRC trans rs9291683 0.530 rs11723591 chr4:9985398 T/A cg26043149 chr18:55253948 FECH 0.54 8.24 0.41 4.04e-15 Bone mineral density; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg15832314 chr15:40401289 BMF 0.41 6.0 0.31 5.24e-9 Response to antipsychotic treatment; CRC cis rs3018066 0.768 rs4355394 chr4:106946814 C/G cg01869342 chr4:106983673 TBCK 0.4 6.11 0.32 2.77e-9 Cancer; CRC cis rs56399783 0.808 rs73049331 chr7:2799911 C/T cg23627948 chr7:2760692 NA 0.47 5.63 0.3 3.79e-8 Childhood ear infection; CRC cis rs7762018 0.514 rs60671539 chr6:170165981 A/G cg24289452 chr6:170231220 NA -0.62 -9.03 -0.45 1.49e-17 Thiazide-induced adverse metabolic effects in hypertensive patients; CRC cis rs28386778 0.933 rs2665804 chr17:61951836 G/T cg23090583 chr17:61904693 PSMC5;FTSJ3 1.01 18.96 0.72 1.05e-54 Prudent dietary pattern; CRC cis rs751728 0.664 rs2395402 chr6:33753673 G/A cg25922239 chr6:33757077 LEMD2 0.46 6.88 0.35 3.11e-11 Crohn's disease; CRC cis rs4841097 0.876 rs6601288 chr8:8943430 A/T cg06636001 chr8:8085503 FLJ10661 0.5 7.31 0.37 2.04e-12 Platelet distribution width; CRC cis rs6964587 1.000 rs1859113 chr7:91679887 T/C cg17063962 chr7:91808500 NA 0.8 14.21 0.62 4.48e-36 Breast cancer; CRC cis rs2228479 0.850 rs11648689 chr16:89806732 G/A cg06558623 chr16:89946397 TCF25 1.14 10.79 0.51 1.99e-23 Skin colour saturation; CRC cis rs6809651 0.524 rs1356291 chr3:185824644 C/T cg00760338 chr3:185826511 ETV5 0.75 9.1 0.45 8.77e-18 Body mass index in physically active individuals;Glomerular filtration rate (creatinine);Body mass index (joint analysis main effects and physical activity interaction);Body mass index;Body mass index in physically inactive individuals; CRC cis rs7998202 0.667 rs695163 chr13:113363300 G/A cg01692110 chr13:113365389 ATP11A -0.49 -5.93 -0.31 7.65e-9 Glycated hemoglobin levels; CRC cis rs561341 0.825 rs2008368 chr17:30347397 T/C cg00745463 chr17:30367425 LRRC37B -0.86 -9.48 -0.46 5.41e-19 Hip circumference adjusted for BMI; CRC trans rs2303319 0.504 rs1023835 chr2:162593973 A/G cg18122310 chr12:50236657 BCDIN3D -0.73 -6.35 -0.33 7.23e-10 Cognitive function; CRC cis rs71403859 0.730 rs12927768 chr16:71645263 G/A cg08717414 chr16:71523259 ZNF19 -1.05 -10.04 -0.48 7.5e-21 Post bronchodilator FEV1; CRC cis rs12586317 0.534 rs1568200 chr14:35419592 C/T cg16230307 chr14:35515116 FAM177A1 0.68 8.65 0.43 2.27e-16 Psoriasis; CRC cis rs2075371 0.897 rs1646733 chr7:134002228 C/A cg11752832 chr7:134001865 SLC35B4 0.5 7.69 0.39 1.69e-13 Mean platelet volume; CRC cis rs911119 1.000 rs3088162 chr20:23607752 C/A cg16589663 chr20:23618590 CST3 0.58 7.72 0.39 1.41e-13 Chronic kidney disease; CRC cis rs10242455 0.702 rs7794068 chr7:99146873 A/T cg18809830 chr7:99032528 PTCD1 -1.08 -8.07 -0.41 1.3e-14 Blood metabolite levels; CRC cis rs739401 0.611 rs417957 chr11:3046231 A/G cg08508325 chr11:3079039 CARS -0.52 -9.75 -0.47 6.75e-20 Longevity; CRC trans rs2710642 0.962 rs7567923 chr2:63085848 C/T cg05376469 chr2:102649931 NA 0.38 6.45 0.34 3.95e-10 LDL cholesterol levels;LDL cholesterol; CRC cis rs9359856 0.564 rs11962292 chr6:90476788 C/T cg13799429 chr6:90582589 CASP8AP2 -0.73 -7.27 -0.37 2.57e-12 Bipolar disorder; CRC trans rs208520 0.690 rs1776365 chr6:66834474 G/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.08 -14.89 -0.63 1.12e-38 Exhaled nitric oxide output; CRC cis rs10256972 0.706 rs4285396 chr7:1123738 A/G cg22907277 chr7:1156413 C7orf50 0.66 9.86 0.48 2.89e-20 Longevity;Endometriosis; CRC cis rs9896933 0.779 rs2256316 chr17:80693805 C/G cg15664640 chr17:80829946 TBCD -0.55 -6.08 -0.32 3.31e-9 Bone mineral accretion in asthma (oral corticosteroid dose interaction); CRC cis rs6840360 0.571 rs4696102 chr4:152529658 C/T cg09659197 chr4:152720779 NA 0.31 5.63 0.3 3.8e-8 Intelligence (multi-trait analysis); CRC cis rs17384381 0.953 rs11161599 chr1:85795965 A/G cg16011679 chr1:85725395 C1orf52 -0.61 -6.21 -0.32 1.59e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs7119 0.651 rs12904208 chr15:77845911 C/T cg27398640 chr15:77910606 LINGO1 -0.41 -6.85 -0.35 3.59e-11 Type 2 diabetes; CRC trans rs12310956 0.532 rs1589902 chr12:33989289 G/A cg26384229 chr12:38710491 ALG10B 0.47 6.28 0.33 1.06e-9 Morning vs. evening chronotype; CRC cis rs9814567 0.712 rs4955545 chr3:134332926 A/G cg06109529 chr3:134205091 CEP63;ANAPC13 -0.67 -9.58 -0.47 2.53e-19 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs2153535 0.601 rs2143353 chr6:8530111 T/G cg21535247 chr6:8435926 SLC35B3 0.48 7.35 0.38 1.6e-12 Motion sickness; CRC cis rs6952808 0.929 rs34145223 chr7:1926237 G/A cg22963979 chr7:1858916 MAD1L1 -0.5 -7.48 -0.38 6.67e-13 Bipolar disorder and schizophrenia; CRC cis rs6062302 0.522 rs13038448 chr20:62218453 C/T cg09650180 chr20:62225654 GMEB2 -0.5 -6.81 -0.35 4.69e-11 Glioblastoma; CRC trans rs4902562 0.838 rs6573823 chr14:68733632 A/G cg15776653 chr6:26538476 HMGN4 0.46 5.96 0.31 6.35e-9 Systemic lupus erythematosus; CRC cis rs7940866 0.903 rs1347283 chr11:130868583 T/G cg12179176 chr11:130786555 SNX19 0.56 8.1 0.41 1.1e-14 Schizophrenia; CRC cis rs4988958 0.584 rs12712149 chr2:103045193 A/G cg03938978 chr2:103052716 IL18RAP 0.59 10.09 0.49 4.82e-21 Asthma (childhood onset); CRC cis rs853679 0.517 rs9380055 chr6:28081629 A/G cg12273811 chr6:28175739 NA 0.73 9.18 0.45 4.85e-18 Depression; CRC cis rs875971 0.767 rs1695815 chr7:65831344 A/G cg18876405 chr7:65276391 NA 0.52 9.04 0.45 1.37e-17 Aortic root size; CRC cis rs2836974 0.666 rs35182074 chr21:40685284 A/C cg17971929 chr21:40555470 PSMG1 -0.68 -9.93 -0.48 1.71e-20 Cognitive function; CRC cis rs3096299 0.685 rs4785676 chr16:89553624 T/C cg02187348 chr16:89574699 SPG7 0.4 6.02 0.31 4.68e-9 Multiple myeloma (IgH translocation); CRC cis rs10779751 0.879 rs7543400 chr1:11283964 C/G cg08854313 chr1:11322531 MTOR 0.77 12.02 0.55 7.44e-28 Body mass index; CRC cis rs6973256 0.605 rs7808879 chr7:133345471 A/T cg10665199 chr7:133106180 EXOC4 0.49 7.71 0.39 1.52e-13 Intelligence (multi-trait analysis); CRC cis rs1983891 0.774 rs6935446 chr6:41514372 A/G cg20194872 chr6:41519635 FOXP4 0.39 5.6 0.3 4.51e-8 Prostate cancer; CRC cis rs2439831 0.850 rs11070408 chr15:44034788 G/A cg02155558 chr15:43621948 ADAL;LCMT2 0.68 7.47 0.38 7.39e-13 Lung cancer in ever smokers; CRC cis rs270601 0.770 rs932019 chr5:131599370 T/C cg12564285 chr5:131593104 PDLIM4 0.55 10.56 0.5 1.24e-22 Acylcarnitine levels; CRC cis rs2386661 0.547 rs57893347 chr10:5646191 G/A cg12223502 chr10:5658492 NA -0.37 -5.91 -0.31 8.63e-9 Breast cancer; CRC cis rs17376456 0.569 rs6556839 chr5:93206292 T/C cg09848695 chr5:92956644 FAM172A;MIR2277 -0.53 -5.95 -0.31 6.73e-9 Diabetic retinopathy; CRC cis rs6684514 1.000 rs3806409 chr1:156252291 A/G cg16558208 chr1:156270281 VHLL 0.58 9.04 0.45 1.34e-17 Mean corpuscular hemoglobin concentration;Glycated hemoglobin levels; CRC cis rs3096299 0.719 rs2965945 chr16:89514017 T/C cg00750074 chr16:89608354 SPG7 -0.48 -7.44 -0.38 8.69e-13 Multiple myeloma (IgH translocation); CRC cis rs6952808 0.595 rs2398705 chr7:2164995 G/A cg21782813 chr7:2030301 MAD1L1 0.56 9.62 0.47 1.78e-19 Bipolar disorder and schizophrenia; CRC cis rs56011263 0.687 rs11734460 chr4:705074 C/T cg05835009 chr4:710272 PCGF3 0.53 7.08 0.36 9e-12 White blood cell count; CRC cis rs78456975 1.000 rs6744743 chr2:1558161 C/T cg26248373 chr2:1572462 NA 0.63 6.86 0.35 3.53e-11 Placebo response in major depressive disorder (% change in symptom score); CRC cis rs875971 0.505 rs6955582 chr7:65431686 A/G cg05627663 chr7:65219948 SNORA22;CCT6P1 0.48 7.19 0.37 4.52e-12 Aortic root size; CRC cis rs1401999 0.898 rs9876143 chr3:183731362 C/G cg01324343 chr3:183735012 ABCC5 0.79 14.32 0.62 1.73e-36 Anterior chamber depth; CRC cis rs6543140 0.927 rs917999 chr2:103067869 G/A cg04239558 chr2:103089729 SLC9A4 0.37 6.6 0.34 1.64e-10 Blood protein levels; CRC cis rs4665809 0.590 rs7588328 chr2:26469788 G/A cg22920501 chr2:26401640 FAM59B 0.85 12.21 0.56 1.54e-28 Gut microbiome composition (summer); CRC cis rs2857891 1.000 rs1388527 chr11:6948441 C/T cg26870460 chr11:6947759 ZNF215 0.56 5.88 0.31 1.01e-8 Response to cytadine analogues (cytosine arabinoside); CRC cis rs4862750 0.872 rs4862748 chr4:187877388 C/T cg06074448 chr4:187884817 NA 0.5 8.13 0.41 9.02e-15 Lobe attachment (rater-scored or self-reported); CRC cis rs728616 0.614 rs61859196 chr10:82109048 A/G cg05935833 chr10:81318306 SFTPA2 -0.6 -7.28 -0.37 2.52e-12 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs274567 0.501 rs581968 chr5:131710202 G/A cg04518342 chr5:131593106 PDLIM4 -0.43 -7.01 -0.36 1.39e-11 Blood metabolite levels; CRC cis rs6502050 0.835 rs11654584 chr17:80079435 A/T cg22110888 chr17:80059540 CCDC57 0.43 6.79 0.35 5.35e-11 Life satisfaction; CRC cis rs9399135 1.000 rs6569988 chr6:135352303 C/A cg22676075 chr6:135203613 NA 0.4 6.06 0.32 3.67e-9 Red blood cell count; CRC cis rs7647973 0.667 rs6446286 chr3:49681704 A/G cg03060546 chr3:49711283 APEH 0.68 8.2 0.41 5.37e-15 Menarche (age at onset); CRC cis rs2985684 0.901 rs2354448 chr14:50098296 G/A cg04989706 chr14:50066350 PPIL5 -0.49 -6.92 -0.36 2.32e-11 Carotid intima media thickness; CRC cis rs372883 0.600 rs2832291 chr21:30734388 C/T cg24692254 chr21:30365293 RNF160 0.58 8.69 0.43 1.76e-16 Pancreatic cancer; CRC cis rs2576037 0.526 rs7234570 chr18:44459656 A/G cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.55 9.4 0.46 9.67e-19 Personality dimensions; CRC cis rs2120019 0.938 rs3850093 chr15:75318482 A/G cg17294928 chr15:75287854 SCAMP5 0.76 10.02 0.48 8.79e-21 Blood trace element (Zn levels); CRC cis rs807669 0.903 rs2854643 chr22:19189706 T/C cg02655711 chr22:19163373 SLC25A1 0.98 20.16 0.74 2.01e-59 Metabolite levels; CRC trans rs4824093 0.610 rs58888255 chr22:50315627 G/A cg09872104 chr7:134855509 C7orf49 -0.8 -6.57 -0.34 1.99e-10 Amyotrophic lateral sclerosis (sporadic); CRC cis rs9914988 0.943 rs9891925 chr17:27104540 A/T cg07195577 chr17:27052828 TLCD1 0.42 6.02 0.32 4.64e-9 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs7953249 0.618 rs7954331 chr12:121398657 G/T cg02403541 chr12:121454288 C12orf43 -0.42 -5.99 -0.31 5.36e-9 Invasive epithelial ovarian cancer;High-grade serous ovarian cancer;Chronic obstructive pulmonary disease-related biomarkers;N-glycan levels;Serous invasive ovarian cancer;Epithelial ovarian cancer; CRC cis rs1552244 0.608 rs7615408 chr3:10000186 A/G cg02579736 chr3:10068473 FANCD2;CIDECP 0.66 9.37 0.46 1.24e-18 Alzheimer's disease; CRC cis rs6840360 0.837 rs4696294 chr4:152713089 C/A cg09659197 chr4:152720779 NA -0.54 -11.64 -0.54 1.86e-26 Intelligence (multi-trait analysis); CRC cis rs7104764 0.507 rs6598054 chr11:254010 C/T cg00562011 chr11:252351 PSMD13 0.53 6.17 0.32 2.04e-9 Menarche (age at onset); CRC cis rs10924970 0.967 rs3765793 chr1:235368277 T/A cg26050004 chr1:235667680 B3GALNT2 0.39 5.77 0.3 1.8e-8 Asthma; CRC cis rs798554 0.797 rs798487 chr7:2802943 G/A cg04166393 chr7:2884313 GNA12 0.51 6.76 0.35 6.28e-11 Height; CRC cis rs7666738 0.830 rs9994346 chr4:99037986 A/G cg05340658 chr4:99064831 C4orf37 0.6 9.26 0.45 2.7e-18 Colonoscopy-negative controls vs population controls; CRC cis rs6674176 0.597 rs4031031 chr1:44393533 C/T cg13606994 chr1:44402422 ARTN -0.34 -5.63 -0.3 3.78e-8 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Cognitive ability; CRC cis rs4332037 0.539 rs57148375 chr7:2025001 G/C cg24505167 chr7:1915268 MAD1L1 -0.45 -6.3 -0.33 9.35e-10 Bipolar disorder; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg08125682 chr16:11038455 CLEC16A -0.42 -6.36 -0.33 6.68e-10 Myopia (pathological); CRC cis rs6663390 0.831 rs2267894 chr1:208085735 G/A cg03990033 chr1:208084030 CD34 0.48 6.44 0.33 4.23e-10 Facial morphology (factor 18); CRC cis rs7639513 0.767 rs9861271 chr3:12707620 A/C cg23032965 chr3:12705835 RAF1 0.64 9.88 0.48 2.45e-20 Itch intensity from mosquito bite; CRC cis rs875971 0.862 rs35034167 chr7:65580166 C/G cg18876405 chr7:65276391 NA -0.51 -8.54 -0.43 4.92e-16 Aortic root size; CRC cis rs11958404 0.932 rs7706111 chr5:157416053 C/T cg05962755 chr5:157440814 NA 0.74 10.43 0.5 3.4e-22 IgG glycosylation; CRC cis rs2290159 0.800 rs5746195 chr3:12653800 A/G cg23032965 chr3:12705835 RAF1 0.49 6.31 0.33 9.24e-10 Cholesterol, total; CRC cis rs2032447 0.714 rs199726 chr6:25953360 G/A cg18357526 chr6:26021779 HIST1H4A 0.68 10.08 0.49 5.36e-21 Intelligence (multi-trait analysis); CRC cis rs9517313 0.591 rs9554480 chr13:99221138 T/A cg07423050 chr13:99094983 FARP1 -0.51 -7.3 -0.37 2.17e-12 Neuroticism; CRC cis rs7618915 0.547 rs2268026 chr3:52778347 T/C cg18099408 chr3:52552593 STAB1 -0.44 -7.24 -0.37 3.28e-12 Bipolar disorder; CRC cis rs4824093 0.610 rs13340054 chr22:50311726 G/A cg22709217 chr22:50311962 ALG12;CRELD2 -0.95 -9.05 -0.45 1.31e-17 Amyotrophic lateral sclerosis (sporadic); CRC cis rs3106136 0.609 rs12500027 chr4:95107918 T/C cg11021082 chr4:95130006 SMARCAD1 -0.44 -6.3 -0.33 9.32e-10 Capecitabine sensitivity; CRC trans rs12210905 1.000 rs67310631 chr6:27233243 T/A cg05005425 chr1:167687389 NA 0.62 6.29 0.33 1.03e-9 Hip circumference adjusted for BMI; CRC cis rs6918586 0.658 rs198829 chr6:26118893 A/G cg18357526 chr6:26021779 HIST1H4A -0.49 -7.29 -0.37 2.27e-12 Schizophrenia; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg03066081 chr17:77784036 NA 0.48 6.95 0.36 1.96e-11 Response to antipsychotic treatment; CRC cis rs400736 0.930 rs2745722 chr1:8056669 G/A cg25007680 chr1:8021821 PARK7 0.53 7.54 0.38 4.53e-13 Response to antidepressants and depression; CRC trans rs916888 0.610 rs199436 chr17:44789285 C/T cg22968622 chr17:43663579 NA -0.89 -12.09 -0.55 4.3e-28 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs7917772 0.503 rs7893155 chr10:104294228 C/A cg22532475 chr10:104410764 TRIM8 -0.36 -6.8 -0.35 5.08e-11 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC cis rs7618915 0.547 rs62253703 chr3:52632357 T/C cg05573699 chr3:52720067 GNL3;PBRM1 -0.46 -6.57 -0.34 2.01e-10 Bipolar disorder; CRC cis rs449789 0.502 rs529281 chr6:159708505 T/C cg14500486 chr6:159655392 FNDC1 -0.48 -7.29 -0.37 2.38e-12 Pulse pressure; CRC cis rs4819052 1.000 rs9306123 chr21:46709922 A/G cg11663144 chr21:46675770 NA -0.77 -10.95 -0.52 5.41e-24 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs7666738 0.830 rs7664305 chr4:99037691 G/A cg17366294 chr4:99064904 C4orf37 0.44 7.47 0.38 7.18e-13 Colonoscopy-negative controls vs population controls; CRC cis rs4974559 0.947 rs10000797 chr4:1345647 G/A cg02980000 chr4:1222292 CTBP1 0.73 8.38 0.42 1.52e-15 Systolic blood pressure; CRC cis rs2290159 0.706 rs6442319 chr3:12647029 G/A cg23032965 chr3:12705835 RAF1 0.49 6.31 0.33 9.24e-10 Cholesterol, total; CRC cis rs4481887 0.962 rs6686911 chr1:248476969 T/C cg00666640 chr1:248458726 OR2T12 0.55 9.51 0.46 4.31e-19 Common traits (Other); CRC cis rs4722166 0.597 rs2069845 chr7:22770149 G/A cg26061582 chr7:22766209 IL6 0.54 8.84 0.44 5.95e-17 Lung cancer; CRC trans rs9354308 0.840 rs1827157 chr6:66615761 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.47 6.11 0.32 2.74e-9 Metabolite levels; CRC cis rs7212590 0.655 rs16943969 chr17:58031153 A/G cg10252138 chr17:58120427 NA -0.59 -6.33 -0.33 7.87e-10 Granulocyte percentage of myeloid white cells;Monocyte count;Monocyte percentage of white cells; CRC cis rs8180040 0.966 rs13064843 chr3:47415467 C/T cg27129171 chr3:47204927 SETD2 0.52 8.11 0.41 9.97e-15 Colorectal cancer; CRC cis rs4713118 0.662 rs464312 chr6:27967591 T/A cg10876282 chr6:28092338 ZSCAN16 0.44 5.88 0.31 9.85e-9 Parkinson's disease; CRC trans rs2303319 0.504 rs56407015 chr2:162455625 G/A cg22988483 chr14:93581567 ITPK1 -0.66 -6.07 -0.32 3.43e-9 Cognitive function; CRC cis rs2857891 0.909 rs56261447 chr11:6939382 A/C cg12728517 chr11:6947552 ZNF215 0.55 5.81 0.31 1.48e-8 Response to cytadine analogues (cytosine arabinoside); CRC cis rs11098499 0.954 rs6834796 chr4:120414693 A/C cg24375607 chr4:120327624 NA 0.48 7.3 0.37 2.12e-12 Corneal astigmatism; CRC cis rs17270561 0.636 rs7754814 chr6:25745243 A/T cg16482183 chr6:26056742 HIST1H1C 0.83 10.69 0.51 4.46e-23 Iron status biomarkers; CRC cis rs7705042 0.865 rs7723666 chr5:141513966 C/T cg07392085 chr5:141489673 NDFIP1 0.46 7.33 0.37 1.85e-12 Asthma; CRC cis rs1570884 0.890 rs6561541 chr13:50127280 C/T cg08779649 chr13:50194554 NA 0.35 6.76 0.35 6.34e-11 Sum basophil neutrophil counts;Sum neutrophil eosinophil counts;Neutrophil count;Myeloid white cell count;Granulocyte count; CRC cis rs3617 0.573 rs9850563 chr3:52912214 G/A cg15147215 chr3:52552868 STAB1 0.48 8.12 0.41 9.24e-15 Red blood cell count;Autism spectrum disorder or schizophrenia; CRC cis rs877282 0.797 rs35927768 chr10:753095 T/C cg17470449 chr10:769945 NA 0.61 7.82 0.4 7e-14 Uric acid levels; CRC cis rs2011503 1.000 rs1036215 chr19:19657198 C/T cg11584989 chr19:19387371 SF4 0.57 5.78 0.3 1.72e-8 Bipolar disorder; CRC cis rs2836633 0.965 rs2836621 chr21:40054149 C/T cg05519781 chr21:40033154 ERG 0.61 11.42 0.53 1.13e-25 Coronary artery disease; CRC cis rs427941 0.703 rs201445 chr7:101737921 G/T cg06246474 chr7:101738831 CUX1 0.46 7.16 0.37 5.46e-12 Plasma omega-3 polyunsaturated fatty acid level (eicosapentaenoic acid); CRC cis rs2013441 0.711 rs1682297 chr17:20384920 C/T cg13482628 chr17:19912719 NA 0.42 6.32 0.33 8.54e-10 Obesity-related traits; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg26812362 chr6:167040675 RPS6KA2 0.48 6.72 0.35 8.05e-11 Anxiety disorder; CRC cis rs4713118 0.911 rs2394000 chr6:27686991 A/G cg21204522 chr6:27730016 NA -0.41 -5.61 -0.3 4.28e-8 Parkinson's disease; CRC cis rs1997103 0.954 rs4947505 chr7:55409448 T/C cg17469321 chr7:55412551 NA 0.72 11.16 0.52 9.79e-25 QRS interval (sulfonylurea treatment interaction); CRC cis rs35520189 0.591 rs12466653 chr2:113700988 A/G cg12858261 chr2:113808755 IL1F8 0.49 6.87 0.35 3.29e-11 Obstructive sleep apnea trait (apnea hypopnea index); CRC cis rs9325144 0.555 rs1825806 chr12:38692547 G/A cg26384229 chr12:38710491 ALG10B 0.58 8.54 0.43 5.02e-16 Morning vs. evening chronotype; CRC cis rs2836974 0.931 rs8132285 chr21:40655752 T/C cg06238570 chr21:40685208 BRWD1 0.79 10.86 0.51 1.11e-23 Cognitive function; CRC cis rs1865760 0.566 rs9379825 chr6:26083871 C/A cg17691542 chr6:26056736 HIST1H1C 0.54 8.16 0.41 7.07e-15 Height; CRC cis rs1215050 0.740 rs1648568 chr4:98957619 A/G cg05340658 chr4:99064831 C4orf37 -0.49 -7.6 -0.39 3.06e-13 Waist-to-hip ratio adjusted for body mass index; CRC cis rs34172651 0.517 rs11642954 chr16:24824248 G/A cg06028605 chr16:24865363 SLC5A11 0.58 9.59 0.47 2.22e-19 Intelligence (multi-trait analysis); CRC cis rs758324 0.773 rs2404777 chr5:131172803 C/A cg25547332 chr5:131281432 NA 0.35 5.68 0.3 3.03e-8 Alzheimer's disease in APOE e4- carriers; CRC cis rs7811142 0.943 rs3900792 chr7:100004577 C/G cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.62 8.22 0.41 4.91e-15 Platelet count; CRC cis rs7618501 1.000 rs11130218 chr3:49752372 C/T cg24308560 chr3:49941425 MST1R 0.47 7.37 0.38 1.42e-12 Intelligence (multi-trait analysis); CRC cis rs1707322 0.721 rs4431884 chr1:46101323 C/T cg06784218 chr1:46089804 CCDC17 0.63 11.78 0.54 5.67e-27 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs9640161 0.659 rs7781827 chr7:150008858 T/C cg12556325 chr7:150026731 C7orf29;LRRC61 -0.4 -6.3 -0.33 9.68e-10 Blood protein levels;Circulating chemerin levels; CRC cis rs9322193 0.962 rs10452626 chr6:150088617 T/C cg00933542 chr6:150070202 PCMT1 0.28 5.69 0.3 2.75e-8 Lung cancer; CRC cis rs4664293 0.836 rs73967923 chr2:160658265 G/A cg08347373 chr2:160653686 CD302 -0.41 -6.35 -0.33 7.13e-10 Monocyte percentage of white cells; CRC cis rs929354 0.772 rs6954050 chr7:156978554 A/G cg16102536 chr7:156981717 UBE3C 0.4 6.77 0.35 5.77e-11 Body mass index; CRC cis rs7131987 0.650 rs10843382 chr12:29451721 G/A cg09582351 chr12:29534625 ERGIC2 -0.34 -7.14 -0.37 5.98e-12 QT interval; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg17864040 chr1:78148524 ZZZ3 0.45 6.54 0.34 2.35e-10 Intelligence (multi-trait analysis); CRC cis rs7605378 0.528 rs7592587 chr2:200786516 C/G cg17644776 chr2:200775616 C2orf69 0.48 7.68 0.39 1.86e-13 Osteoporosis; CRC cis rs9916302 0.904 rs6503507 chr17:37525274 C/T cg07936489 chr17:37558343 FBXL20 0.8 12.22 0.56 1.46e-28 Glomerular filtration rate (creatinine); CRC trans rs11764590 0.543 rs55893771 chr7:2096255 C/T cg11693508 chr17:37793320 STARD3 0.54 6.21 0.32 1.6e-9 Neuroticism; CRC cis rs9311474 0.508 rs6786919 chr3:52599789 A/G cg05573699 chr3:52720067 GNL3;PBRM1 -0.44 -6.45 -0.34 3.94e-10 Electroencephalogram traits; CRC cis rs4466137 1.000 rs4466137 chr5:82985739 A/C cg16102102 chr5:83017553 HAPLN1 -0.54 -8.1 -0.41 1.1e-14 Prostate cancer; CRC cis rs2070997 0.816 rs6597643 chr9:133725830 C/T cg01000188 chr9:133769184 QRFP -0.5 -6.0 -0.31 5.22e-9 Response to amphetamines; CRC cis rs7937682 0.737 rs542275 chr11:111431614 C/T cg09085632 chr11:111637200 PPP2R1B -0.75 -12.23 -0.56 1.31e-28 Primary sclerosing cholangitis; CRC cis rs6840360 0.607 rs2724547 chr4:152365576 G/A cg09659197 chr4:152720779 NA 0.34 6.7 0.35 8.91e-11 Intelligence (multi-trait analysis); CRC cis rs2230307 0.536 rs506044 chr1:100611931 A/G cg24955406 chr1:100503596 HIAT1 -0.5 -6.02 -0.31 4.66e-9 Carotid intima media thickness; CRC cis rs909341 0.678 rs2738778 chr20:62291830 C/T cg16989086 chr20:62203971 PRIC285 0.51 6.44 0.33 4.3e-10 Atopic dermatitis; CRC cis rs6840360 1.000 rs6810860 chr4:152603164 C/T cg09659197 chr4:152720779 NA -0.51 -10.81 -0.51 1.62e-23 Intelligence (multi-trait analysis); CRC cis rs6973256 0.583 rs2345943 chr7:133340630 A/G cg10665199 chr7:133106180 EXOC4 -0.47 -7.32 -0.37 1.96e-12 Intelligence (multi-trait analysis); CRC cis rs1018836 0.923 rs4734266 chr8:91628147 C/T cg16814680 chr8:91681699 NA -0.75 -11.86 -0.55 3e-27 Ejection fraction in Tripanosoma cruzi seropositivity; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg03067192 chr7:72300134 SBDSP;TYW1B 0.51 6.77 0.35 5.9e-11 Anxiety disorder; CRC trans rs7757969 0.500 rs58691769 chr6:112159068 C/T cg08211895 chr2:48828358 STON1-GTF2A1L 0.31 6.07 0.32 3.57e-9 Schizophrenia; CRC cis rs9311474 1.000 rs7629072 chr3:52305633 C/T cg08222913 chr3:52553049 STAB1 -0.36 -6.85 -0.35 3.68e-11 Electroencephalogram traits; CRC trans rs2243480 1.000 rs7794661 chr7:65389730 T/C cg10756647 chr7:56101905 PSPH 0.75 8.22 0.41 4.6e-15 Diabetic kidney disease; CRC cis rs1153858 1.000 rs9783731 chr15:45642884 C/T cg10760299 chr15:45669010 GATM -0.48 -7.5 -0.38 5.92e-13 Homoarginine levels; CRC cis rs7412746 0.658 rs6660845 chr1:150841066 G/A cg10589385 chr1:150898437 SETDB1 0.32 6.52 0.34 2.59e-10 Melanoma; CRC cis rs12476592 0.543 rs262511 chr2:63889944 C/A cg10828910 chr2:63850056 LOC388955 0.5 6.26 0.33 1.23e-9 Childhood ear infection; CRC cis rs6860806 0.661 rs4705929 chr5:131584178 G/T cg20512303 chr5:131592959 PDLIM4 0.34 6.45 0.33 4.04e-10 Breast cancer; CRC cis rs7605827 0.897 rs1990756 chr2:15616030 C/T cg19274914 chr2:15703543 NA 0.39 5.9 0.31 8.83e-9 Educational attainment (years of education); CRC cis rs6840360 1.000 rs6834095 chr4:152603278 C/T cg09659197 chr4:152720779 NA 0.5 10.75 0.51 2.66e-23 Intelligence (multi-trait analysis); CRC cis rs10256972 0.641 rs12702017 chr7:1129413 C/T cg22907277 chr7:1156413 C7orf50 0.67 10.35 0.5 6.65e-22 Longevity;Endometriosis; CRC trans rs3780486 0.718 rs73645257 chr9:33132354 C/T cg04842962 chr6:43655489 MRPS18A 0.94 11.87 0.55 2.63e-27 IgG glycosylation; CRC trans rs62103177 0.525 rs8086024 chr18:77746623 A/G cg05926928 chr17:57297772 GDPD1 -0.63 -7.75 -0.39 1.17e-13 Opioid sensitivity; CRC cis rs3824867 0.920 rs7130693 chr11:47452321 T/C cg05585544 chr11:47624801 NA 0.41 6.32 0.33 8.5e-10 Mean corpuscular hemoglobin; CRC cis rs2153535 0.601 rs7738877 chr6:8542230 A/G cg21535247 chr6:8435926 SLC35B3 0.46 7.1 0.36 7.62e-12 Motion sickness; CRC cis rs6860806 0.695 rs11952099 chr5:131576772 A/G cg22638593 chr5:131593259 PDLIM4 0.42 7.86 0.4 5.51e-14 Breast cancer; CRC cis rs7584330 0.657 rs10211024 chr2:238353776 A/T cg14458575 chr2:238380390 NA 0.64 11.39 0.53 1.44e-25 Prostate cancer; CRC cis rs9372498 0.536 rs1319987 chr6:118782236 A/G cg10217327 chr6:118973057 C6orf204 0.51 5.76 0.3 1.93e-8 Diastolic blood pressure; CRC cis rs875971 0.862 rs10261398 chr7:65750164 A/G cg12463550 chr7:65579703 CRCP -0.52 -7.39 -0.38 1.23e-12 Aortic root size; CRC cis rs6952808 1.000 rs10233560 chr7:1885415 T/C cg02951883 chr7:2050386 MAD1L1 -0.65 -10.45 -0.5 2.92e-22 Bipolar disorder and schizophrenia; CRC cis rs17253792 0.915 rs75862063 chr14:56177769 G/T cg01858014 chr14:56050164 KTN1 -0.81 -6.11 -0.32 2.87e-9 Putamen volume; CRC cis rs4728302 0.838 rs10225115 chr7:133591435 C/T cg10665199 chr7:133106180 EXOC4 0.38 5.87 0.31 1.04e-8 Intelligence;Intelligence (multi-trait analysis); CRC cis rs13315871 0.929 rs79813245 chr3:58318475 G/A cg20936604 chr3:58311152 NA -0.76 -7.14 -0.37 5.92e-12 Cholesterol, total; CRC trans rs6749447 0.848 rs1517330 chr2:169002552 T/C cg01878807 chr14:24422368 DHRS4;C14orf167 0.41 6.33 0.33 7.83e-10 Blood pressure; CRC cis rs9341808 0.905 rs9343977 chr6:80967001 C/T cg08355045 chr6:80787529 NA 0.41 7.04 0.36 1.12e-11 Sitting height ratio; CRC cis rs35146811 0.735 rs1138417 chr7:99807146 C/G cg13334819 chr7:99746414 C7orf59 0.57 7.38 0.38 1.33e-12 Coronary artery disease; CRC cis rs7474896 0.559 rs1735641 chr10:38184852 C/A cg25427524 chr10:38739819 LOC399744 0.67 8.23 0.41 4.33e-15 Obesity (extreme); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg23979971 chr5:138677953 PAIP2 0.4 6.4 0.33 5.36e-10 Liver disease severity in Alagille syndrome; CRC cis rs7666738 0.830 rs28618180 chr4:98912184 A/C cg17366294 chr4:99064904 C4orf37 0.41 6.73 0.35 7.45e-11 Colonoscopy-negative controls vs population controls; CRC cis rs28386778 0.799 rs12450683 chr17:61984299 C/G cg22520471 chr17:61851767 DDX42;CCDC47 0.62 9.87 0.48 2.64e-20 Prudent dietary pattern; CRC cis rs425277 0.583 rs3107151 chr1:2051513 T/G cg04315214 chr1:2043799 PRKCZ 0.54 9.77 0.47 5.67e-20 Height; CRC cis rs57221529 0.709 rs72706612 chr5:561198 C/T cg16447950 chr5:562315 NA -0.83 -11.29 -0.53 3.41e-25 Lung disease severity in cystic fibrosis; CRC cis rs679087 0.659 rs302318 chr12:29921667 T/C cg14258853 chr12:29935411 TMTC1 -0.34 -6.1 -0.32 2.9e-9 Schizophrenia; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg10233691 chr16:67062760 CBFB 0.37 6.06 0.32 3.67e-9 Liver disease severity in Alagille syndrome; CRC cis rs11690935 0.959 rs4668412 chr2:172619770 A/G cg13550731 chr2:172543902 DYNC1I2 -1.09 -17.95 -0.7 1.01e-50 Schizophrenia; CRC cis rs6951245 0.554 rs10246354 chr7:1132456 C/T cg23978390 chr7:1156363 C7orf50 0.51 5.72 0.3 2.4e-8 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs703842 0.642 rs11536137 chr12:58056426 C/A cg00677455 chr12:58241039 CTDSP2 0.56 6.78 0.35 5.6e-11 Multiple sclerosis; CRC cis rs858239 0.899 rs5850 chr7:23314547 C/T cg00469287 chr7:23338798 C7orf30 0.47 5.91 0.31 8.63e-9 Cerebrospinal fluid biomarker levels; CRC cis rs6502050 0.835 rs4789744 chr17:80101506 A/C cg11859384 chr17:80120422 CCDC57 -0.37 -5.85 -0.31 1.16e-8 Life satisfaction; CRC cis rs6764363 0.506 rs13091217 chr3:277778 A/G cg02057681 chr3:285234 CHL1 0.41 7.01 0.36 1.37e-11 Sudden cardiac arrest; CRC trans rs11722228 0.508 rs3796826 chr4:10092728 G/A cg26043149 chr18:55253948 FECH 1.12 17.34 0.69 2.69e-48 Gout;Urate levels;Serum uric acid levels; CRC trans rs1864729 1.000 rs2853318 chr8:98283509 A/T cg08679828 chr8:102218111 ZNF706 -0.59 -7.13 -0.37 6.34e-12 Estradiol plasma levels (breast cancer); CRC cis rs4901869 0.966 rs4901870 chr14:59334221 A/T cg02291164 chr14:59296302 NA -0.33 -6.05 -0.32 3.92e-9 Panic disorder; CRC cis rs10504229 0.683 rs58883273 chr8:58138275 A/G cg02725872 chr8:58115012 NA -0.64 -11.55 -0.54 3.85e-26 Developmental language disorder (linguistic errors); CRC cis rs56114371 0.777 rs200483 chr6:27774824 C/T cg08798685 chr6:27730294 NA -0.61 -5.78 -0.3 1.73e-8 Breast cancer; CRC cis rs3858526 0.959 rs11039699 chr11:5951091 G/A cg05234568 chr11:5960015 NA -0.58 -8.0 -0.4 2.08e-14 DNA methylation (variation); CRC cis rs60843830 1.000 rs3791224 chr2:221981 C/T cg00108164 chr2:264199 ACP1;SH3YL1 0.62 9.8 0.48 4.79e-20 Spherical equivalent (joint analysis main effects and education interaction); CRC cis rs9858542 0.953 rs9827021 chr3:49514764 C/A cg07274523 chr3:49395745 GPX1 0.46 6.23 0.32 1.43e-9 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs1451375 0.712 rs11974297 chr7:50618260 A/G cg14593290 chr7:50529359 DDC 0.46 6.78 0.35 5.53e-11 Malaria; CRC cis rs910316 1.000 rs10143132 chr14:75525850 G/A cg03030879 chr14:75389066 RPS6KL1 -0.46 -7.14 -0.37 6.14e-12 Height; CRC trans rs459571 0.959 rs465724 chr9:136910097 C/T cg15028160 chr19:49622717 PPFIA3;C19orf73 -0.55 -7.23 -0.37 3.5e-12 Platelet distribution width; CRC cis rs11785400 0.753 rs9694286 chr8:143737157 G/T cg10596483 chr8:143751796 JRK 0.44 5.95 0.31 6.73e-9 Schizophrenia; CRC cis rs7762018 0.891 rs73242950 chr6:170144737 C/T cg17545662 chr6:170176663 C6orf70 0.57 6.45 0.34 3.99e-10 Thiazide-induced adverse metabolic effects in hypertensive patients; CRC cis rs896854 0.812 rs2340586 chr8:95969261 G/A cg13393036 chr8:95962371 TP53INP1 -0.53 -9.02 -0.45 1.64e-17 Type 2 diabetes; CRC cis rs7843479 0.601 rs10109521 chr8:21829948 G/A cg16476235 chr8:21771668 DOK2 0.39 6.66 0.34 1.13e-10 Mean corpuscular volume; CRC trans rs7615952 0.688 rs7624806 chr3:125599074 G/A cg00769240 chr8:12517080 NA -0.55 -6.41 -0.33 5.09e-10 Blood pressure (smoking interaction); CRC cis rs4285028 0.747 rs1920299 chr3:121593769 A/G cg20356878 chr3:121714668 ILDR1 0.47 6.4 0.33 5.22e-10 Multiple sclerosis; CRC cis rs2535633 0.602 rs2581816 chr3:53014657 C/T cg05573699 chr3:52720067 GNL3;PBRM1 -0.41 -6.05 -0.32 4.02e-9 Body mass index; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg04104609 chr2:219523980 ZNF142;BCS1L 0.41 6.12 0.32 2.64e-9 Liver disease severity in Alagille syndrome; CRC cis rs6570726 0.791 rs436156 chr6:145874873 A/G cg05347473 chr6:146136440 FBXO30 0.4 6.1 0.32 2.93e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs7412746 0.658 rs3768016 chr1:150809919 T/C cg18016565 chr1:150552671 MCL1 0.43 5.89 0.31 9.59e-9 Melanoma; CRC cis rs875971 0.830 rs6976714 chr7:65891461 G/A cg18252515 chr7:66147081 NA -0.41 -5.8 -0.3 1.52e-8 Aortic root size; CRC cis rs4665809 0.652 rs10779956 chr2:26405985 A/G cg25036284 chr2:26402008 FAM59B -0.62 -7.72 -0.39 1.44e-13 Gut microbiome composition (summer); CRC cis rs9322193 0.923 rs11155670 chr6:149966128 C/G cg05861140 chr6:150128134 PCMT1 -0.36 -5.67 -0.3 3.07e-8 Lung cancer; CRC cis rs9487051 0.714 rs7774390 chr6:109602461 C/G cg01475377 chr6:109611718 NA 0.38 6.58 0.34 1.86e-10 Reticulocyte fraction of red cells; CRC cis rs806215 1.000 rs806216 chr7:127237862 C/A cg25922125 chr7:127225783 GCC1 -0.72 -7.54 -0.38 4.61e-13 Type 2 diabetes; CRC cis rs4713118 0.869 rs6901520 chr6:27714575 G/T cg20933634 chr6:27740509 NA 0.58 8.63 0.43 2.69e-16 Parkinson's disease; CRC cis rs1570884 0.516 rs2146144 chr13:50170245 C/T cg02321871 chr13:50159138 RCBTB1 -0.43 -6.13 -0.32 2.5e-9 Sum basophil neutrophil counts;Sum neutrophil eosinophil counts;Neutrophil count;Myeloid white cell count;Granulocyte count; CRC cis rs2487048 0.725 rs2422493 chr9:107690995 G/A cg14470647 chr9:107690075 ABCA1 -0.38 -5.7 -0.3 2.62e-8 Intraocular pressure; CRC cis rs1862618 0.756 rs13356762 chr5:56110992 G/T cg18230493 chr5:56204884 C5orf35 -0.72 -9.26 -0.45 2.63e-18 Initial pursuit acceleration; CRC cis rs9309473 0.950 rs1918863 chr2:73644481 A/G cg20560298 chr2:73613845 ALMS1 -0.48 -5.88 -0.31 1e-8 Metabolite levels; CRC cis rs875971 1.000 rs4717300 chr7:65947380 T/C cg18912574 chr7:65842487 NCRNA00174 0.36 6.08 0.32 3.39e-9 Aortic root size; CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg07145255 chr5:59995354 DEPDC1B -0.51 -6.22 -0.32 1.55e-9 Diisocyanate-induced asthma; CRC cis rs7487075 0.964 rs2408497 chr12:46796751 A/G cg22049899 chr12:47219821 SLC38A4 0.33 6.53 0.34 2.53e-10 Itch intensity from mosquito bite; CRC cis rs6502050 0.835 rs67682841 chr17:80117745 T/C cg19223190 chr17:80058835 NA 0.38 6.17 0.32 2e-9 Life satisfaction; CRC cis rs7772486 0.624 rs6930154 chr6:146025662 C/T cg13319975 chr6:146136371 FBXO30 0.46 6.92 0.36 2.33e-11 Lobe attachment (rater-scored or self-reported); CRC cis rs892961 0.899 rs312911 chr17:75414585 A/C cg01320579 chr17:75405842 SEPT9 0.35 5.62 0.3 4.18e-8 Airflow obstruction; CRC trans rs1997103 1.000 rs10252413 chr7:55396740 C/G cg20935933 chr6:143382018 AIG1 0.52 6.6 0.34 1.67e-10 QRS interval (sulfonylurea treatment interaction); CRC cis rs35883536 0.647 rs12043865 chr1:101042651 G/A cg06223162 chr1:101003688 GPR88 -0.36 -6.62 -0.34 1.44e-10 Monocyte count; CRC cis rs7927771 0.800 rs55876153 chr11:47416636 G/A cg20307385 chr11:47447363 PSMC3 -0.64 -9.25 -0.45 2.98e-18 Subjective well-being; CRC cis rs875971 0.522 rs2008188 chr7:65429013 G/C cg11764359 chr7:65958608 NA 0.51 7.72 0.39 1.4e-13 Aortic root size; CRC cis rs12143943 0.866 rs3789052 chr1:204494283 A/G cg17419461 chr1:204415978 PIK3C2B -0.39 -6.06 -0.32 3.8e-9 Cognitive performance; CRC cis rs7811142 0.830 rs705866 chr7:99965285 T/C cg00814883 chr7:100076585 TSC22D4 -0.72 -8.56 -0.43 4.25e-16 Platelet count; CRC cis rs2836974 0.666 rs12626405 chr21:40663121 G/T cg11890956 chr21:40555474 PSMG1 -0.89 -15.25 -0.64 4.4e-40 Cognitive function; CRC cis rs6838801 0.892 rs10029193 chr4:77576894 G/A cg17476223 chr4:77663285 SHROOM3 0.42 5.84 0.31 1.28e-8 Cleft lip with or without cleft palate; CRC cis rs8078723 0.714 rs2241245 chr17:38151014 C/T cg17344932 chr17:38183730 MED24;SNORD124 0.48 7.98 0.4 2.38e-14 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); CRC cis rs897984 0.683 rs12447534 chr16:30804257 C/T cg02466173 chr16:30829666 NA 0.81 13.73 0.6 3.13e-34 Dementia with Lewy bodies; CRC cis rs10504229 0.639 rs17331850 chr8:58113538 G/T cg22535103 chr8:58192502 C8orf71 -0.69 -9.23 -0.45 3.37e-18 Developmental language disorder (linguistic errors); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg13456812 chr6:167369504 RNASET2 0.45 6.32 0.33 8.36e-10 Response to antipsychotic treatment; CRC cis rs1697139 0.583 rs13186050 chr5:66528139 C/T cg16691251 chr5:66510806 NA 0.46 8.15 0.41 7.58e-15 Breast cancer; CRC cis rs4665809 1.000 rs4665819 chr2:26309073 A/G cg26119090 chr2:26468346 HADHA;HADHB -0.61 -7.91 -0.4 3.92e-14 Gut microbiome composition (summer); CRC cis rs7149337 0.752 rs8021773 chr14:51691528 C/T cg18683604 chr14:51561293 TRIM9 0.32 6.23 0.32 1.46e-9 Cancer; CRC cis rs736408 0.812 rs6778329 chr3:52824610 G/A cg15147215 chr3:52552868 STAB1 -0.55 -8.45 -0.42 9.79e-16 Bipolar disorder; CRC cis rs10463316 0.894 rs4246024 chr5:150740987 C/T cg03212797 chr5:150827313 SLC36A1 -0.5 -7.61 -0.39 2.95e-13 Metabolite levels (Pyroglutamine); CRC cis rs7811142 1.000 rs7811142 chr7:100065443 A/T cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.75 10.17 0.49 2.66e-21 Platelet count; CRC cis rs6502050 0.835 rs3935128 chr17:80113414 T/C cg02741985 chr17:80059408 CCDC57 0.43 7.15 0.37 5.66e-12 Life satisfaction; CRC cis rs6543140 0.964 rs1523206 chr2:103070175 A/T cg09003973 chr2:102972529 NA 0.41 5.77 0.3 1.85e-8 Blood protein levels; CRC cis rs56104184 0.775 rs73061697 chr19:49400000 C/T cg21252483 chr19:49399788 TULP2 -0.43 -6.62 -0.34 1.49e-10 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; CRC cis rs10911251 0.528 rs10911248 chr1:183080564 G/A ch.1.3577855R chr1:183094577 LAMC1 0.88 15.62 0.65 1.5e-41 Colorectal cancer; CRC cis rs8180040 1.000 rs1024037 chr3:47318449 C/A cg27129171 chr3:47204927 SETD2 -0.66 -10.27 -0.49 1.22e-21 Colorectal cancer; CRC cis rs7937682 0.855 rs521947 chr11:111492616 A/G cg09085632 chr11:111637200 PPP2R1B -0.98 -19.21 -0.73 1.09e-55 Primary sclerosing cholangitis; CRC cis rs11098499 0.730 rs78971550 chr4:120281041 C/T cg09307838 chr4:120376055 NA 0.68 10.32 0.49 8.06e-22 Corneal astigmatism; CRC cis rs6424115 0.692 rs573361 chr1:24053674 A/T cg15997130 chr1:24165203 NA 0.7 10.36 0.5 6.11e-22 Immature fraction of reticulocytes; CRC cis rs875971 0.545 rs67775320 chr7:65658779 T/C cg03233332 chr7:66118400 NA -0.45 -6.35 -0.33 7.16e-10 Aortic root size; CRC cis rs4803468 0.967 rs13345590 chr19:41886455 T/G cg09537434 chr19:41945824 ATP5SL -0.95 -17.98 -0.7 7.61e-51 Height; CRC trans rs10983614 1.000 rs7867776 chr9:120072627 A/G cg01511126 chr1:40506125 CAP1 0.45 6.07 0.32 3.46e-9 Survival in pancreatic cancer; CRC cis rs77861329 1.000 rs17051957 chr3:52099441 A/G cg08692210 chr3:52188851 WDR51A 0.81 8.14 0.41 8.15e-15 Macrophage inflammatory protein 1b levels; CRC cis rs6860806 0.507 rs270606 chr5:131650867 A/G cg24060327 chr5:131705240 SLC22A5 -0.52 -7.55 -0.38 4.21e-13 Breast cancer; CRC cis rs13108904 0.905 rs1680074 chr4:1279621 G/A cg24560729 chr4:1342394 KIAA1530 -0.34 -6.25 -0.33 1.25e-9 Obesity-related traits; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg07951810 chr12:65153561 GNS 0.41 6.2 0.32 1.68e-9 Liver disease severity in Alagille syndrome; CRC cis rs4665809 0.627 rs13014338 chr2:26463024 C/T cg04944784 chr2:26401820 FAM59B 0.83 10.74 0.51 2.96e-23 Gut microbiome composition (summer); CRC cis rs1577917 0.771 rs2842609 chr6:86296788 G/A cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.67 -8.79 -0.44 8.78e-17 Response to antipsychotic treatment; CRC trans rs916888 0.779 rs199498 chr17:44865603 A/G cg10053473 chr17:62856997 LRRC37A3 -0.64 -7.72 -0.39 1.37e-13 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs2243480 0.708 rs35825036 chr7:65986502 T/C cg18252515 chr7:66147081 NA -1.29 -15.43 -0.65 8.74e-41 Diabetic kidney disease; CRC cis rs9398803 0.932 rs9401876 chr6:126669479 C/A cg19875578 chr6:126661172 C6orf173 0.41 5.64 0.3 3.69e-8 Male-pattern baldness; CRC cis rs6088580 0.634 rs4277599 chr20:33008905 A/G cg08999081 chr20:33150536 PIGU -0.57 -11.21 -0.53 6.19e-25 Glomerular filtration rate (creatinine); CRC cis rs9549328 0.670 rs61963562 chr13:113616523 T/G cg17524180 chr13:113633600 MCF2L 0.52 9.39 0.46 1e-18 Systolic blood pressure; CRC cis rs11645898 0.935 rs72787091 chr16:72190184 C/T cg14768367 chr16:72042858 DHODH -0.59 -6.54 -0.34 2.32e-10 Blood protein levels; CRC cis rs76878669 0.561 rs10896112 chr11:66116836 G/C cg18002602 chr11:66138449 SLC29A2 -0.32 -6.73 -0.35 7.78e-11 Educational attainment (years of education); CRC cis rs7786808 0.649 rs1377374 chr7:158215647 G/T cg09998033 chr7:158218633 PTPRN2 0.51 7.31 0.37 1.98e-12 Obesity-related traits; CRC cis rs11122272 0.701 rs11582413 chr1:231530098 C/G cg06096015 chr1:231504339 EGLN1 0.41 6.18 0.32 1.91e-9 Hemoglobin concentration; CRC cis rs9910055 1.000 rs9895423 chr17:42285740 T/C cg16434002 chr17:42200994 HDAC5 -0.47 -6.38 -0.33 6.16e-10 Total body bone mineral density; CRC cis rs4713118 0.512 rs2622319 chr6:28120401 G/C cg23161317 chr6:28129485 ZNF389 0.46 6.42 0.33 4.71e-10 Parkinson's disease; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg24184350 chr6:11094094 LOC221710 0.48 6.62 0.34 1.49e-10 Anxiety disorder; CRC cis rs2404602 0.692 rs7169663 chr15:77192843 A/C cg22467129 chr15:76604101 ETFA -0.38 -6.08 -0.32 3.42e-9 Blood metabolite levels; CRC trans rs1814175 0.746 rs10839429 chr11:49906845 G/A cg15704280 chr7:45808275 SEPT13 -1.02 -20.57 -0.75 5.09e-61 Height; CRC cis rs1003719 0.715 rs8128387 chr21:38556787 G/C cg10648535 chr21:38446584 PIGP;TTC3 -0.48 -6.67 -0.35 1.08e-10 Eye color traits; CRC cis rs2180341 0.961 rs7774468 chr6:127592501 G/C cg24812749 chr6:127587940 RNF146 0.93 13.41 0.59 4.97e-33 Breast cancer; CRC cis rs2227564 0.830 rs2675667 chr10:75683832 G/A cg00564723 chr10:75632066 CAMK2G -0.32 -7.12 -0.37 7e-12 Crohn's disease;Inflammatory bowel disease; CRC cis rs56091001 0.528 rs9616387 chr22:50313219 G/A cg22709217 chr22:50311962 ALG12;CRELD2 -0.91 -7.68 -0.39 1.83e-13 Acne (severe); CRC cis rs7224685 0.501 rs781845 chr17:3958341 A/G cg09695851 chr17:3907499 NA -0.76 -14.18 -0.62 6.22e-36 Type 2 diabetes; CRC trans rs5756813 0.661 rs2071910 chr22:38204259 C/T cg19894588 chr14:64061835 NA -0.63 -8.62 -0.43 2.78e-16 Optic cup area;Vertical cup-disc ratio; CRC cis rs9325144 0.625 rs11534879 chr12:38968165 A/G cg26384229 chr12:38710491 ALG10B -0.52 -7.44 -0.38 8.91e-13 Morning vs. evening chronotype; CRC cis rs2857891 0.909 rs17191140 chr11:6944283 G/A cg17084751 chr11:6953558 ZNF215 -0.53 -5.95 -0.31 6.99e-9 Response to cytadine analogues (cytosine arabinoside); CRC cis rs3857536 0.842 rs2188591 chr6:66939511 A/T cg07460842 chr6:66804631 NA -0.43 -5.81 -0.3 1.48e-8 Blood trace element (Cu levels); CRC cis rs3823572 0.542 rs2971961 chr7:133639737 G/A cg03336402 chr7:133662267 EXOC4 0.66 10.12 0.49 3.87e-21 Intelligence (multi-trait analysis); CRC cis rs7927592 0.913 rs11228262 chr11:68274907 G/T cg01657329 chr11:68192670 LRP5 -0.46 -6.5 -0.34 2.97e-10 Total body bone mineral density; CRC cis rs875971 0.502 rs1796227 chr7:66087019 G/C cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.62 -7.9 -0.4 4.12e-14 Aortic root size; CRC cis rs9287719 0.967 rs7600820 chr2:10740044 A/G cg00105475 chr2:10696890 NA 0.45 7.3 0.37 2.19e-12 Prostate cancer; CRC cis rs62432291 0.764 rs433256 chr6:159660105 C/T cg14500486 chr6:159655392 FNDC1 -0.75 -10.23 -0.49 1.6e-21 Joint mobility (Beighton score); CRC cis rs10131894 0.611 rs175001 chr14:75436452 A/C cg03030879 chr14:75389066 RPS6KL1 -0.39 -5.83 -0.31 1.33e-8 Coronary artery disease; CRC cis rs17401966 0.838 rs12737239 chr1:10323973 C/G cg19773385 chr1:10388646 KIF1B -0.68 -11.18 -0.52 8.18e-25 Hepatocellular carcinoma; CRC trans rs16873450 0.527 rs11982084 chr7:23782716 G/C cg19535980 chr5:159519152 PWWP2A -0.41 -5.99 -0.31 5.43e-9 Verbal memory performance (residualized delayed recall level); CRC cis rs6696846 0.765 rs61822619 chr1:205090885 C/G cg00857998 chr1:205179979 DSTYK 0.46 6.31 0.33 8.9e-10 Red blood cell count; CRC cis rs10193935 0.901 rs13384323 chr2:42631346 C/T cg27598129 chr2:42591480 NA -0.61 -7.37 -0.38 1.38e-12 Colonoscopy-negative controls vs population controls; CRC cis rs7618501 0.635 rs34080578 chr3:50026029 A/C cg24308560 chr3:49941425 MST1R -0.51 -8.36 -0.42 1.83e-15 Intelligence (multi-trait analysis); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg02071957 chr16:19191409 SYT17 0.42 6.02 0.31 4.77e-9 Intelligence (multi-trait analysis); CRC trans rs561341 1.000 rs483301 chr17:30293398 G/T cg20587970 chr11:113659929 NA -1.42 -20.2 -0.74 1.43e-59 Hip circumference adjusted for BMI; CRC cis rs853679 0.517 rs3757185 chr6:28107776 T/A cg03623178 chr6:28175578 NA 0.96 12.57 0.57 7.23e-30 Depression; CRC cis rs929354 0.772 rs6459737 chr7:156975136 G/A cg17757837 chr7:157058334 UBE3C 0.74 12.57 0.57 7.46e-30 Body mass index; CRC cis rs1153858 1.000 rs1049503 chr15:45653707 T/C cg10760299 chr15:45669010 GATM 0.51 8.27 0.41 3.46e-15 Homoarginine levels; CRC cis rs3126085 0.935 rs4845423 chr1:152184950 T/G cg09127314 chr1:152161683 NA 0.5 6.38 0.33 5.88e-10 Atopic dermatitis; CRC cis rs73200209 0.744 rs61939680 chr12:116493867 G/A cg01776926 chr12:116560359 MED13L -0.64 -7.35 -0.38 1.57e-12 Total body bone mineral density; CRC cis rs11971779 0.680 rs6467846 chr7:139079385 G/T cg23387468 chr7:139079360 LUC7L2 0.41 7.04 0.36 1.14e-11 Diisocyanate-induced asthma; CRC cis rs7914558 0.966 rs1890185 chr10:104748718 A/G cg04362960 chr10:104952993 NT5C2 0.62 9.43 0.46 7.38e-19 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs4332037 0.722 rs7788921 chr7:1915282 C/A cg24505167 chr7:1915268 MAD1L1 -0.49 -7.51 -0.38 5.64e-13 Bipolar disorder; CRC cis rs7568458 0.846 rs7605975 chr2:85772548 C/T cg02493740 chr2:85810744 VAMP5 -0.38 -6.08 -0.32 3.28e-9 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); CRC cis rs2635047 0.935 rs2635050 chr18:44664131 G/A cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.42 6.86 0.35 3.52e-11 Educational attainment; CRC cis rs4965006 0.915 rs7969545 chr12:132419157 C/T cg00588090 chr12:132412438 PUS1 -0.47 -6.26 -0.33 1.21e-9 Posterior cortical atrophy and Alzheimer's disease; CRC cis rs10504229 0.593 rs10504216 chr8:57981470 G/A cg22535103 chr8:58192502 C8orf71 -0.65 -6.83 -0.35 4.11e-11 Developmental language disorder (linguistic errors); CRC trans rs11098499 1.000 rs13116504 chr4:120209412 A/C cg25214090 chr10:38739885 LOC399744 0.51 7.89 0.4 4.49e-14 Corneal astigmatism; CRC cis rs651907 0.535 rs13084113 chr3:101534039 C/G cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.57 7.43 0.38 9.57e-13 Colorectal cancer; CRC cis rs2380220 0.678 rs4308568 chr6:96009525 A/C cg04719120 chr6:96025338 MANEA -0.68 -8.57 -0.43 3.94e-16 Behavioural disinhibition (generation interaction); CRC cis rs1865760 0.622 rs9968910 chr6:26072095 A/C cg16482183 chr6:26056742 HIST1H1C 0.64 8.76 0.43 1.06e-16 Height; CRC cis rs6665290 0.870 rs17600725 chr1:227204231 A/G cg10327440 chr1:227177885 CDC42BPA -0.99 -20.27 -0.75 7.31e-60 Myeloid white cell count; CRC cis rs13108904 0.539 rs13141992 chr4:1340765 C/T cg24560729 chr4:1342394 KIAA1530 0.39 6.27 0.33 1.15e-9 Obesity-related traits; CRC trans rs10504229 1.000 rs66886949 chr8:58187613 A/G cg04077850 chr5:125800366 GRAMD3 0.37 6.27 0.33 1.15e-9 Developmental language disorder (linguistic errors); CRC cis rs875971 0.723 rs28391294 chr7:65654315 T/C cg11764359 chr7:65958608 NA -0.6 -9.36 -0.46 1.25e-18 Aortic root size; CRC cis rs2839186 0.934 rs13049797 chr21:47707582 T/C cg09417038 chr21:47716443 C21orf57 -0.42 -6.93 -0.36 2.21e-11 Testicular germ cell tumor; CRC cis rs4713118 0.513 rs156738 chr6:28014025 G/C cg10876282 chr6:28092338 ZSCAN16 0.49 6.57 0.34 1.99e-10 Parkinson's disease; CRC cis rs9807989 0.507 rs3732124 chr2:103018052 A/G cg03938978 chr2:103052716 IL18RAP -0.6 -10.23 -0.49 1.6e-21 Asthma; CRC trans rs6951245 0.529 rs76001997 chr7:1152615 C/T cg13565492 chr6:43139072 SRF -0.83 -10.56 -0.5 1.23e-22 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs4594175 0.926 rs10873044 chr14:51615856 T/C cg23942311 chr14:51606299 NA 0.67 11.24 0.53 4.9e-25 Cancer; CRC trans rs7395662 0.759 rs4347397 chr11:48895946 T/C cg21153622 chr11:89784906 NA 0.47 7.44 0.38 8.86e-13 HDL cholesterol; CRC cis rs477895 0.713 rs11601024 chr11:63943074 A/G cg23719950 chr11:63933701 MACROD1 -0.66 -8.54 -0.43 4.94e-16 Mean platelet volume; CRC cis rs9300255 0.722 rs11830103 chr12:123823546 A/G cg00376283 chr12:123451042 ABCB9 -0.54 -7.18 -0.37 4.78e-12 Neutrophil percentage of white cells; CRC cis rs7546094 1.000 rs12728001 chr1:113076756 T/C cg22162597 chr1:113214053 CAPZA1 0.41 5.69 0.3 2.83e-8 Platelet distribution width; CRC cis rs8180040 0.739 rs66539935 chr3:47025327 C/T cg27129171 chr3:47204927 SETD2 -0.64 -9.98 -0.48 1.19e-20 Colorectal cancer; CRC cis rs9488822 0.676 rs3798227 chr6:116324898 A/G cg05304507 chr6:116381966 FRK 0.3 8.24 0.41 4.08e-15 Cholesterol, total;LDL cholesterol; CRC cis rs72634258 0.945 rs12748993 chr1:8129507 A/G cg26816564 chr1:7831052 VAMP3 0.51 5.83 0.31 1.34e-8 Inflammatory bowel disease; CRC cis rs6500602 0.727 rs1477123 chr16:4560627 T/A cg06139259 chr16:4526053 HMOX2;NMRAL1 0.52 6.95 0.36 2.02e-11 Schizophrenia; CRC cis rs2204008 0.777 rs2049130 chr12:38444837 G/A cg26384229 chr12:38710491 ALG10B 0.64 8.86 0.44 5.13e-17 Bladder cancer; CRC cis rs9549328 0.565 rs35371379 chr13:113616715 T/C cg25790453 chr13:113633590 MCF2L 0.43 7.51 0.38 5.75e-13 Systolic blood pressure; CRC trans rs6550704 0.687 rs9865314 chr3:22634337 A/G cg21800906 chr11:32914818 QSER1 -0.42 -6.3 -0.33 9.43e-10 Daytime sleep phenotypes; CRC cis rs7312933 0.558 rs1796384 chr12:42780568 G/A cg19980929 chr12:42632907 YAF2 -0.41 -6.27 -0.33 1.16e-9 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CRC cis rs6586163 1.000 rs3824729 chr10:90752616 A/G cg13456138 chr10:90753195 FAS -0.44 -6.8 -0.35 5.07e-11 Chronic lymphocytic leukemia; CRC cis rs7927592 0.913 rs59056571 chr11:68272973 T/G cg16797656 chr11:68205561 LRP5 0.37 5.83 0.31 1.3e-8 Total body bone mineral density; CRC cis rs6499255 0.903 rs1800566 chr16:69745145 C/T cg05250797 chr16:70222502 NA 0.4 5.69 0.3 2.85e-8 IgE levels; CRC cis rs490234 0.676 rs13293034 chr9:128256951 C/T cg14078157 chr9:128172775 NA -0.39 -6.33 -0.33 7.91e-10 Mean arterial pressure; CRC cis rs853679 0.550 rs1237875 chr6:28173010 A/G cg02683197 chr6:28174875 NA -0.88 -12.39 -0.56 3.29e-29 Depression; CRC cis rs7208859 0.623 rs9911490 chr17:29073013 C/T cg13385521 chr17:29058706 SUZ12P 0.72 8.17 0.41 6.77e-15 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs736408 0.522 rs11716747 chr3:52748857 C/T cg15147215 chr3:52552868 STAB1 -0.63 -10.57 -0.5 1.14e-22 Bipolar disorder; CRC cis rs3849570 1.000 rs3849570 chr3:81792112 C/A cg07356753 chr3:81810745 GBE1 -0.74 -11.13 -0.52 1.26e-24 Waist circumference;Body mass index; CRC cis rs4141404 0.818 rs5997897 chr22:31570436 G/A cg22777020 chr22:31556080 RNF185 -0.45 -5.8 -0.3 1.52e-8 Paclitaxel-induced neuropathy; CRC cis rs1552244 0.938 rs66915020 chr3:10110174 A/G cg08888203 chr3:10149979 C3orf24 0.69 9.74 0.47 7.48e-20 Alzheimer's disease; CRC cis rs9322193 0.923 rs9478291 chr6:150050570 A/G cg00933542 chr6:150070202 PCMT1 0.33 6.86 0.35 3.39e-11 Lung cancer; CRC cis rs7927771 0.524 rs10838775 chr11:47856382 C/G cg20307385 chr11:47447363 PSMC3 0.46 6.66 0.34 1.18e-10 Subjective well-being; CRC cis rs6460942 0.841 rs17443848 chr7:12443688 A/G cg20607287 chr7:12443886 VWDE -0.65 -8.35 -0.42 1.96e-15 Coronary artery disease; CRC cis rs2953145 0.545 rs2975751 chr2:241521135 G/A cg07929629 chr2:241523174 NA 0.66 10.07 0.49 5.64e-21 Bipolar disorder; CRC cis rs34172651 0.917 rs200539 chr16:24735178 T/C cg06028605 chr16:24865363 SLC5A11 -0.44 -8.16 -0.41 7.05e-15 Intelligence (multi-trait analysis); CRC trans rs2727020 0.619 rs11040300 chr11:49269984 C/A cg03929089 chr4:120376271 NA 0.59 7.71 0.39 1.48e-13 Coronary artery disease; CRC cis rs853679 0.517 rs3173443 chr6:28137027 T/G cg21251018 chr6:28226885 NKAPL 0.48 6.17 0.32 2.02e-9 Depression; CRC cis rs9291683 0.595 rs35501905 chr4:10053431 C/T cg11266682 chr4:10021025 SLC2A9 0.52 10.79 0.51 2e-23 Bone mineral density; CRC cis rs1451375 1.000 rs4452748 chr7:50625056 A/C cg14593290 chr7:50529359 DDC -0.56 -7.8 -0.4 8.2e-14 Malaria; CRC cis rs7552404 0.731 rs1493367 chr1:76344011 C/A cg10523679 chr1:76189770 ACADM -0.68 -8.41 -0.42 1.26e-15 Blood metabolite levels;Acylcarnitine levels; CRC cis rs3749237 0.595 rs10865955 chr3:49499829 G/A cg07636037 chr3:49044803 WDR6 0.56 8.09 0.41 1.15e-14 Resting heart rate; CRC trans rs11148252 0.967 rs11620062 chr13:52994026 T/G cg18335740 chr13:41363409 SLC25A15 0.56 8.91 0.44 3.43e-17 Lewy body disease; CRC cis rs11190604 1.000 rs1800662 chr10:102289078 C/A cg16342193 chr10:102329863 NA -0.36 -5.94 -0.31 7.21e-9 Palmitoleic acid (16:1n-7) levels; CRC cis rs4780401 0.539 rs62040604 chr16:11803641 G/A cg01061890 chr16:11836724 TXNDC11 -0.57 -8.13 -0.41 8.99e-15 Rheumatoid arthritis; CRC trans rs7395662 0.571 rs4881998 chr11:48525186 C/T cg15704280 chr7:45808275 SEPT13 -0.48 -6.83 -0.35 4.17e-11 HDL cholesterol; CRC cis rs8180040 0.654 rs4682831 chr3:47027138 A/G cg27129171 chr3:47204927 SETD2 -0.65 -10.19 -0.49 2.27e-21 Colorectal cancer; CRC cis rs7894051 0.717 rs4838741 chr10:135206873 C/T cg05676341 chr10:135206831 MTG1 0.94 8.13 0.41 8.82e-15 Lifespan; CRC cis rs3785574 0.962 rs2665835 chr17:61903258 C/T cg22520471 chr17:61851767 DDX42;CCDC47 0.47 6.37 0.33 6.35e-10 Height; CRC trans rs4332037 0.539 rs34809719 chr7:2028968 G/T cg11693508 chr17:37793320 STARD3 0.63 7.34 0.38 1.73e-12 Bipolar disorder; CRC cis rs1799949 1.000 rs12942277 chr17:41187974 G/C cg23758822 chr17:41437982 NA 0.82 13.33 0.59 1e-32 Menopause (age at onset); CRC cis rs926938 0.520 rs6663115 chr1:115272254 G/A cg12756093 chr1:115239321 AMPD1 -0.66 -9.12 -0.45 7.53e-18 Autism; CRC trans rs11039571 0.544 rs7947811 chr11:48167738 C/T cg15704280 chr7:45808275 SEPT13 -0.7 -7.5 -0.38 5.85e-13 D-dimer levels; CRC cis rs898097 0.812 rs72859941 chr17:80837459 G/A cg15664640 chr17:80829946 TBCD -0.71 -11.97 -0.55 1.2e-27 Breast cancer; CRC cis rs6429082 0.714 rs184108 chr1:235646160 A/G cg26050004 chr1:235667680 B3GALNT2 0.58 7.96 0.4 2.87e-14 Adiposity; CRC cis rs6502050 0.799 rs4132775 chr17:80155412 C/T cg22110888 chr17:80059540 CCDC57 0.39 6.2 0.32 1.71e-9 Life satisfaction; CRC cis rs7527798 0.592 rs6702222 chr1:207825627 C/T cg09232269 chr1:207846808 CR1L -0.45 -7.31 -0.37 2.02e-12 Erythrocyte sedimentation rate; CRC cis rs6831352 0.918 rs29001201 chr4:100053861 T/C cg13256891 chr4:100009986 ADH5 -0.64 -8.59 -0.43 3.43e-16 Alcohol dependence; CRC cis rs7945705 0.875 rs4929914 chr11:8824388 C/T cg21881798 chr11:8931708 C11orf17;ST5 -0.56 -8.57 -0.43 3.95e-16 Hemoglobin concentration; CRC cis rs2033711 0.654 rs734380 chr19:58898963 A/C cg26874164 chr19:58962979 ZNF324B 0.4 5.86 0.31 1.12e-8 Uric acid clearance; CRC cis rs7959452 0.535 rs10784771 chr12:69621264 A/G cg20891283 chr12:69753455 YEATS4 0.79 13.3 0.59 1.29e-32 Blood protein levels; CRC cis rs9467603 1.000 rs9467603 chr6:25803712 A/G cg08501292 chr6:25962987 TRIM38 1.08 9.37 0.46 1.19e-18 Intelligence (multi-trait analysis); CRC cis rs9381040 0.610 rs6941090 chr6:41043465 G/A cg03644281 chr6:41068752 NFYA;LOC221442 -0.43 -6.02 -0.32 4.63e-9 Alzheimer's disease (late onset); CRC cis rs28386778 0.863 rs9897229 chr17:61782325 T/C cg25654072 chr17:61904446 PSMC5;FTSJ3 0.72 10.8 0.51 1.84e-23 Prudent dietary pattern; CRC cis rs1904096 0.506 rs4693378 chr4:95168552 A/T cg11021082 chr4:95130006 SMARCAD1 -0.6 -9.45 -0.46 6.49e-19 Type 2 diabetes; CRC cis rs9894429 0.789 rs7219915 chr17:79591813 C/T cg21984481 chr17:79567631 NPLOC4 -0.58 -11.19 -0.52 7.81e-25 Eye color traits; CRC cis rs3617 0.573 rs12492391 chr3:52912296 C/A cg11645453 chr3:52864694 ITIH4 0.34 6.29 0.33 1.02e-9 Red blood cell count;Autism spectrum disorder or schizophrenia; CRC cis rs79349575 0.783 rs318096 chr17:46975370 G/A cg00947319 chr17:47005597 UBE2Z -0.34 -5.94 -0.31 7.18e-9 Type 2 diabetes; CRC cis rs7333181 0.649 rs7339379 chr13:112237995 A/G cg27543320 chr13:112200689 NA -0.53 -9.48 -0.46 5.35e-19 Menopause (age at onset); CRC cis rs6570726 0.935 rs376991 chr6:145828073 G/C cg05347473 chr6:146136440 FBXO30 0.37 6.0 0.31 5.27e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs1865760 0.566 rs1800702 chr6:26086463 C/G cg16482183 chr6:26056742 HIST1H1C 0.52 7.58 0.39 3.66e-13 Height; CRC cis rs40363 1.000 rs1635393 chr16:3520493 C/T cg00484396 chr16:3507460 NAT15 0.72 8.35 0.42 1.93e-15 Tuberculosis; CRC trans rs61931739 0.500 rs6488213 chr12:34393319 C/T cg26384229 chr12:38710491 ALG10B 0.61 9.02 0.45 1.59e-17 Morning vs. evening chronotype; CRC cis rs929354 0.742 rs7785227 chr7:156999297 C/T cg17757837 chr7:157058334 UBE3C 0.74 12.6 0.57 5.83e-30 Body mass index; CRC cis rs9916302 0.851 rs11078907 chr17:37662954 C/T cg07936489 chr17:37558343 FBXL20 -0.84 -13.24 -0.59 2.32e-32 Glomerular filtration rate (creatinine); CRC cis rs896854 1.000 rs896854 chr8:95960511 T/C cg23172400 chr8:95962367 TP53INP1 -0.48 -7.96 -0.4 2.88e-14 Type 2 diabetes; CRC cis rs763121 0.853 rs5757193 chr22:39034867 A/G cg06022373 chr22:39101656 GTPBP1 -0.78 -11.51 -0.54 5.41e-26 Menopause (age at onset); CRC cis rs1639906 0.560 rs1637730 chr7:2260928 T/C cg19897017 chr7:2163380 MAD1L1 0.41 5.93 0.31 7.8e-9 Colonoscopy-negative controls vs population controls; CRC cis rs9611519 0.929 rs926914 chr22:41418154 C/T cg03806693 chr22:41940476 POLR3H -0.57 -7.12 -0.37 6.97e-12 Neuroticism; CRC cis rs6500602 0.702 rs6500605 chr16:4502410 C/T cg08645402 chr16:4508243 NA 0.61 10.84 0.51 1.34e-23 Schizophrenia; CRC trans rs6550704 0.687 rs9865314 chr3:22634337 A/G cg03232753 chr17:29233269 C17orf42 -0.4 -5.98 -0.31 5.9e-9 Daytime sleep phenotypes; CRC cis rs2739330 0.828 rs2877178 chr22:24251517 C/T cg18538332 chr22:24372958 LOC391322 -0.71 -10.96 -0.52 5e-24 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs4132509 0.793 rs12037013 chr1:243784207 G/A cg21452805 chr1:244014465 NA 0.59 6.29 0.33 1.01e-9 RR interval (heart rate); CRC cis rs13118159 0.771 rs13117476 chr4:1334721 A/G cg15763984 chr4:1342303 KIAA1530 0.48 8.36 0.42 1.83e-15 Longevity; CRC trans rs6499188 0.522 rs8046299 chr16:68672346 G/A cg04657470 chr2:198365150 HSPE1;HSPD1 0.62 8.17 0.41 6.63e-15 Ulcerative colitis; CRC cis rs4713118 0.527 rs4713151 chr6:28136356 G/A cg15786705 chr6:28176104 NA 0.78 9.83 0.48 3.57e-20 Parkinson's disease; CRC cis rs9560113 0.960 rs953260 chr13:112173685 C/T cg14154082 chr13:112174009 NA 0.35 5.61 0.3 4.24e-8 Menarche (age at onset); CRC trans rs9291683 0.588 rs17247314 chr4:10004743 C/G cg26043149 chr18:55253948 FECH 0.54 8.11 0.41 9.99e-15 Bone mineral density; CRC cis rs208520 1.000 rs72880045 chr6:66965232 A/C cg07460842 chr6:66804631 NA 0.92 11.34 0.53 2.21e-25 Exhaled nitric oxide output; CRC cis rs10504229 0.683 rs6999984 chr8:58115079 G/A cg02290350 chr8:58132656 NA -0.58 -8.23 -0.41 4.53e-15 Developmental language disorder (linguistic errors); CRC cis rs9427116 0.502 rs9426827 chr1:154589965 T/C cg17218026 chr1:154582156 ADAR 0.67 11.65 0.54 1.71e-26 Blood protein levels; CRC cis rs5769765 1.000 rs761879 chr22:50241210 G/A cg22709217 chr22:50311962 ALG12;CRELD2 0.97 15.08 0.64 1.97e-39 Schizophrenia; CRC cis rs523522 0.924 rs11065150 chr12:120958875 T/G cg12219531 chr12:120966889 COQ5 0.69 9.28 0.46 2.36e-18 High light scatter reticulocyte count; CRC cis rs6662572 1.000 rs7541935 chr1:46217493 C/T cg03123370 chr1:45965343 CCDC163P;MMACHC 0.48 5.76 0.3 1.94e-8 Blood protein levels; CRC cis rs9837602 0.529 rs793459 chr3:99520591 G/A cg08350549 chr3:99591722 C3orf26;FILIP1L;MIR548G -0.38 -5.87 -0.31 1.05e-8 Breast cancer; CRC cis rs7591163 0.959 rs11685995 chr2:228722008 T/C cg23807890 chr2:228736357 WDR69 -0.47 -6.58 -0.34 1.9e-10 Blood pressure; CRC cis rs8103278 0.507 rs8112282 chr19:46265029 C/T cg14061069 chr19:46274453 DMPK 0.67 12.48 0.57 1.64e-29 Coronary artery disease; CRC cis rs4713118 0.513 rs183244 chr6:28031838 C/A cg15845792 chr6:28175446 NA 0.8 11.85 0.55 3.22e-27 Parkinson's disease; CRC cis rs1862618 0.627 rs744023 chr5:56197078 C/T cg18230493 chr5:56204884 C5orf35 -0.92 -11.14 -0.52 1.17e-24 Initial pursuit acceleration; CRC cis rs10461617 0.592 rs6450403 chr5:56062737 A/C cg20203395 chr5:56204925 C5orf35 -0.51 -6.38 -0.33 5.98e-10 Type 2 diabetes; CRC cis rs11645898 1.000 rs72791117 chr16:72217385 T/C cg14768367 chr16:72042858 DHODH -0.6 -6.76 -0.35 6.35e-11 Blood protein levels; CRC cis rs7635838 0.892 rs9852530 chr3:11466469 C/T cg00170343 chr3:11313890 ATG7 0.41 6.29 0.33 1.03e-9 HDL cholesterol; CRC cis rs2243480 1.000 rs34192067 chr7:65887657 C/A cg12463550 chr7:65579703 CRCP 0.7 6.26 0.33 1.22e-9 Diabetic kidney disease; CRC cis rs34779708 0.649 rs34421369 chr10:35550275 G/C cg03585969 chr10:35415529 CREM 0.5 6.49 0.34 3.17e-10 Inflammatory bowel disease;Crohn's disease; CRC cis rs10504229 0.636 rs117439064 chr8:58055279 A/G cg24829409 chr8:58192753 C8orf71 -0.64 -7.96 -0.4 2.9e-14 Developmental language disorder (linguistic errors); CRC cis rs8005677 1.000 rs2295683 chr14:23388382 A/C cg01529538 chr14:23388837 RBM23 0.4 6.18 0.32 1.86e-9 Cognitive ability (multi-trait analysis); CRC cis rs9359856 0.518 rs12662171 chr6:90193898 G/C cg13799429 chr6:90582589 CASP8AP2 -0.51 -5.62 -0.3 4.04e-8 Bipolar disorder; CRC cis rs4713118 0.662 rs469228 chr6:27970704 A/G cg20933634 chr6:27740509 NA 0.42 5.85 0.31 1.21e-8 Parkinson's disease; CRC cis rs11098499 0.863 rs59732491 chr4:120489588 G/C cg09307838 chr4:120376055 NA 0.71 10.46 0.5 2.62e-22 Corneal astigmatism; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg07974125 chr4:57843509 C4orf14 0.44 5.98 0.31 5.7e-9 Response to antipsychotic treatment; CRC cis rs6938 0.662 rs12487 chr15:75136694 A/G cg05627522 chr15:75251581 NA 0.38 5.72 0.3 2.46e-8 Breast cancer; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg17585343 chr11:43702103 HSD17B12 0.42 6.23 0.32 1.43e-9 Response to antipsychotic treatment; CRC cis rs720844 0.684 rs16828816 chr2:149305525 A/T cg09247360 chr2:149335327 NA -0.57 -5.98 -0.31 5.8e-9 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs748404 0.660 rs2602141 chr15:43724646 A/C cg02155558 chr15:43621948 ADAL;LCMT2 0.52 7.76 0.39 1.07e-13 Lung cancer; CRC cis rs4843747 0.671 rs72818576 chr16:88111019 C/G cg07865391 chr16:88106882 BANP 0.44 5.82 0.31 1.42e-8 Menopause (age at onset); CRC cis rs10782582 0.593 rs11578480 chr1:76208989 T/G cg10523679 chr1:76189770 ACADM -0.43 -6.13 -0.32 2.53e-9 Daytime sleep phenotypes; CRC trans rs11148252 0.683 rs9536006 chr13:52887707 T/G cg18335740 chr13:41363409 SLC25A15 0.55 8.45 0.42 9.31e-16 Lewy body disease; CRC cis rs9388451 0.839 rs3757217 chr6:126069636 G/C cg05901451 chr6:126070800 HEY2 -0.68 -11.97 -0.55 1.16e-27 Brugada syndrome; CRC cis rs896854 0.967 rs10808671 chr8:95967372 A/G cg23172400 chr8:95962367 TP53INP1 -0.49 -8.25 -0.41 3.73e-15 Type 2 diabetes; CRC cis rs728616 0.867 rs61860420 chr10:81739379 G/A cg11900509 chr10:81946545 ANXA11 -0.68 -6.82 -0.35 4.39e-11 Chronic obstructive pulmonary disease-related biomarkers; CRC trans rs561341 0.941 rs8066558 chr17:30272879 G/T cg27661571 chr11:113659931 NA -0.71 -8.85 -0.44 5.32e-17 Hip circumference adjusted for BMI; CRC cis rs7615952 0.534 rs1503072 chr3:125754691 C/T cg05084668 chr3:125655381 ALG1L -0.44 -6.16 -0.32 2.09e-9 Blood pressure (smoking interaction); CRC cis rs1165668 0.755 rs10735390 chr12:104311731 A/G cg21863207 chr12:104234989 NT5DC3 0.47 7.01 0.36 1.34e-11 Coronary heart disease (SNP X SNP interaction); CRC cis rs2228479 0.850 rs17232910 chr16:89839766 G/C cg06558623 chr16:89946397 TCF25 1.13 10.76 0.51 2.47e-23 Skin colour saturation; CRC cis rs2991971 0.967 rs60608374 chr1:46008913 G/A cg15605315 chr1:45957053 TESK2 0.43 6.85 0.35 3.67e-11 High light scatter reticulocyte count; CRC cis rs4713118 0.629 rs203890 chr6:28022248 T/C cg21251018 chr6:28226885 NKAPL 0.46 6.44 0.33 4.18e-10 Parkinson's disease; CRC cis rs3087591 0.960 rs9303642 chr17:29578360 A/G cg24425628 chr17:29625626 OMG;NF1 -0.84 -16.67 -0.68 1.21e-45 Hip circumference; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg06481699 chr7:101458740 CUX1 0.42 6.91 0.36 2.45e-11 Liver disease severity in Alagille syndrome; CRC trans rs2303319 0.504 rs1006427 chr2:162592328 T/C cg22677401 chr17:46026860 NA -0.67 -6.07 -0.32 3.57e-9 Cognitive function; CRC cis rs2404602 1.000 rs12898430 chr15:76874923 G/A cg23625390 chr15:77176239 SCAPER 0.58 8.92 0.44 3.27e-17 Blood metabolite levels; CRC cis rs1448094 0.512 rs7970842 chr12:86243258 C/T cg18827107 chr12:86230957 RASSF9 -0.45 -7.41 -0.38 1.1e-12 Major depressive disorder; CRC cis rs898097 0.625 rs6502017 chr17:80891135 C/T cg10494973 chr17:80897199 TBCD -0.36 -5.63 -0.3 3.87e-8 Breast cancer; CRC cis rs7635838 0.617 rs347587 chr3:11287155 A/G cg00170343 chr3:11313890 ATG7 -0.58 -9.03 -0.45 1.46e-17 HDL cholesterol; CRC cis rs897984 0.609 rs72800847 chr16:31022639 G/A cg02466173 chr16:30829666 NA -0.69 -9.6 -0.47 2.06e-19 Dementia with Lewy bodies; CRC trans rs1997103 0.871 rs1997100 chr7:55399656 C/G cg20935933 chr6:143382018 AIG1 0.54 6.96 0.36 1.86e-11 QRS interval (sulfonylurea treatment interaction); CRC cis rs3093024 0.904 rs3093017 chr6:167541258 C/G cg07741184 chr6:167504864 NA -0.39 -7.0 -0.36 1.41e-11 Rheumatoid arthritis; CRC trans rs1005277 0.579 rs2472175 chr10:38382901 T/G cg23533926 chr12:111358616 MYL2 -0.52 -7.85 -0.4 6.11e-14 Extrinsic epigenetic age acceleration; CRC trans rs8073060 0.559 rs17550632 chr17:33890883 G/C cg19694781 chr19:47549865 TMEM160 1.04 14.04 0.61 1.99e-35 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; CRC cis rs10781543 0.845 rs10781542 chr9:139327439 A/G cg14169450 chr9:139327907 INPP5E 0.35 5.63 0.3 3.77e-8 Monocyte percentage of white cells; CRC cis rs10461617 0.531 rs2662033 chr5:56213410 T/G cg24531977 chr5:56204891 C5orf35 -0.85 -12.09 -0.55 4.26e-28 Type 2 diabetes; CRC cis rs17376456 0.877 rs10066791 chr5:93350255 G/T cg09848695 chr5:92956644 FAM172A;MIR2277 0.66 5.74 0.3 2.18e-8 Diabetic retinopathy; CRC cis rs3008870 0.651 rs2815376 chr1:67508531 G/A cg08660285 chr1:67390436 MIER1;WDR78 0.44 6.0 0.31 5.14e-9 Lymphocyte percentage of white cells; CRC cis rs6988636 1.000 rs16898097 chr8:124195034 G/C cg27053337 chr8:124217698 FAM83A 0.42 6.3 0.33 9.38e-10 Urinary uromodulin levels; CRC cis rs6429082 0.509 rs6699315 chr1:235525253 C/T cg26050004 chr1:235667680 B3GALNT2 -0.44 -6.38 -0.33 5.87e-10 Adiposity; CRC cis rs2976388 0.609 rs2717605 chr8:143801015 T/G cg05569086 chr8:143859399 LYNX1 0.37 6.35 0.33 7.29e-10 Urinary tract infection frequency; CRC cis rs910316 0.663 rs175034 chr14:75463687 T/G cg11812906 chr14:75593930 NEK9 -0.58 -8.87 -0.44 4.75e-17 Height; CRC trans rs916888 0.610 rs199530 chr17:44836653 C/T cg22968622 chr17:43663579 NA -0.78 -10.68 -0.51 4.68e-23 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs9549367 0.713 rs9549352 chr13:113833221 A/G cg24300038 chr13:113819356 PROZ -0.47 -5.78 -0.3 1.76e-8 Platelet distribution width; CRC cis rs875971 0.660 rs1860470 chr7:66103694 G/C cg18876405 chr7:65276391 NA -0.62 -11.16 -0.52 1e-24 Aortic root size; CRC cis rs2576037 0.526 rs2156050 chr18:44455873 A/G cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.55 9.38 0.46 1.07e-18 Personality dimensions; CRC cis rs7937682 0.564 rs11600652 chr11:111754368 A/T cg19812747 chr11:111475976 SIK2 0.42 6.23 0.32 1.44e-9 Primary sclerosing cholangitis; CRC trans rs7461897 0.511 rs1383916 chr8:26825245 A/G cg19592942 chr8:12294380 FAM86B2 -0.62 -5.97 -0.31 6.17e-9 Epilepsy and lamotrigine-induced maculopapular eruptions; CRC cis rs600806 0.815 rs4970758 chr1:109979617 A/G cg23032129 chr1:109941072 SORT1 -0.27 -5.8 -0.3 1.57e-8 Intelligence (multi-trait analysis); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg01483063 chr10:112836471 ADRA2A 0.45 6.33 0.33 7.81e-10 Response to antipsychotic treatment; CRC cis rs6840360 0.593 rs4696286 chr4:152606547 G/A cg09659197 chr4:152720779 NA 0.4 7.79 0.39 9.01e-14 Intelligence (multi-trait analysis); CRC cis rs853679 0.527 rs853683 chr6:28295039 A/G cg03623178 chr6:28175578 NA 0.48 6.59 0.34 1.77e-10 Depression; CRC cis rs9517320 1.000 rs9517320 chr13:99126303 G/T cg20487152 chr13:99095054 FARP1 -0.35 -5.85 -0.31 1.2e-8 Longevity; CRC cis rs9322193 0.961 rs2064520 chr6:149924786 A/T cg07701084 chr6:150067640 NUP43 0.52 7.52 0.38 5.12e-13 Lung cancer; CRC cis rs853679 0.517 rs3173443 chr6:28137027 T/G cg03623178 chr6:28175578 NA 0.98 12.66 0.57 3.31e-30 Depression; CRC cis rs11758351 0.929 rs75475698 chr6:26190609 C/G cg22723502 chr6:26240528 HIST1H4F -0.37 -5.78 -0.3 1.74e-8 Gout;Renal underexcretion gout; CRC cis rs9649213 0.593 rs11760930 chr7:97915789 G/A cg24562669 chr7:97807699 LMTK2 0.44 7.47 0.38 7.1e-13 Prostate cancer (SNP x SNP interaction); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg21468420 chr4:24474668 NA 0.46 6.6 0.34 1.68e-10 Response to antipsychotic treatment; CRC cis rs11148252 0.553 rs7999849 chr13:53249414 A/G cg20354231 chr13:53171401 NA -0.43 -6.95 -0.36 1.99e-11 Lewy body disease; CRC trans rs11466653 1.000 rs6825115 chr4:38778833 G/A cg11403706 chr22:49042600 FAM19A5 0.62 6.11 0.32 2.76e-9 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs4731207 0.596 rs1021080 chr7:124633805 C/T cg23710748 chr7:124431027 NA -0.39 -6.26 -0.33 1.23e-9 Cutaneous malignant melanoma; CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg22081084 chr1:89990230 LRRC8B -0.5 -6.22 -0.32 1.49e-9 Diisocyanate-induced asthma; CRC cis rs11785400 0.793 rs2976399 chr8:143746050 C/T cg24634471 chr8:143751801 JRK 0.46 6.22 0.32 1.54e-9 Schizophrenia; CRC cis rs3796619 0.924 rs4690209 chr4:1077575 G/A cg27284194 chr4:1044797 NA 0.41 6.34 0.33 7.48e-10 Recombination rate (males); CRC cis rs2658782 0.724 rs2248020 chr11:93259965 A/C cg15737290 chr11:93063684 CCDC67 0.54 7.82 0.4 7.45e-14 Pulmonary function decline; CRC cis rs10924970 0.649 rs12036412 chr1:235398812 T/C cg09010748 chr1:235293032 TOMM20 -0.42 -5.77 -0.3 1.86e-8 Asthma; CRC cis rs4363385 0.818 rs10788856 chr1:153011517 G/C cg25856811 chr1:152973957 SPRR3 -0.25 -6.99 -0.36 1.51e-11 Inflammatory skin disease; CRC cis rs172166 0.516 rs1150670 chr6:28130559 A/G cg03623178 chr6:28175578 NA 0.66 10.08 0.49 5.38e-21 Cardiac Troponin-T levels; CRC trans rs1945213 0.694 rs11227181 chr11:55856053 C/T cg03929089 chr4:120376271 NA 0.59 6.66 0.34 1.17e-10 Acute lymphoblastic leukemia (childhood); CRC cis rs28386778 0.897 rs2854208 chr17:61946885 C/T cg23090583 chr17:61904693 PSMC5;FTSJ3 1.03 19.48 0.73 9.51e-57 Prudent dietary pattern; CRC cis rs2153535 0.580 rs9505455 chr6:8478622 A/G cg21535247 chr6:8435926 SLC35B3 0.5 7.51 0.38 5.54e-13 Motion sickness; CRC cis rs875971 0.830 rs7799834 chr7:65880694 A/C cg18912574 chr7:65842487 NCRNA00174 0.36 6.18 0.32 1.88e-9 Aortic root size; CRC cis rs11622475 1.000 rs1187446 chr14:104409896 C/T cg12183467 chr14:104352244 NA -0.48 -6.67 -0.35 1.05e-10 Bipolar disorder; CRC cis rs10504229 0.769 rs17215649 chr8:58152791 A/G cg02725872 chr8:58115012 NA -0.57 -9.07 -0.45 1.09e-17 Developmental language disorder (linguistic errors); CRC cis rs10927875 0.632 rs4661667 chr1:16162731 C/T cg21385522 chr1:16154831 NA -1.05 -17.93 -0.7 1.27e-50 Dilated cardiomyopathy; CRC cis rs13118159 0.801 rs1128427 chr4:1330759 T/C cg21620606 chr4:1342894 KIAA1530 0.53 9.5 0.46 4.66e-19 Longevity; CRC cis rs9322193 0.884 rs11155679 chr6:150080017 T/C cg00933542 chr6:150070202 PCMT1 0.31 5.98 0.31 5.84e-9 Lung cancer; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg15903931 chr8:124780424 FAM91A1 0.44 6.42 0.33 4.89e-10 Intelligence (multi-trait analysis); CRC cis rs2228479 0.702 rs2074903 chr16:89811663 T/C cg06656553 chr16:89960601 TCF25 -0.69 -5.74 -0.3 2.15e-8 Skin colour saturation; CRC cis rs2841277 0.708 rs11623422 chr14:105407031 A/G cg14403583 chr14:105418241 AHNAK2 -0.34 -6.07 -0.32 3.47e-9 Rheumatoid arthritis; CRC cis rs4862750 0.832 rs10007858 chr4:187877492 A/G cg06074448 chr4:187884817 NA -0.59 -10.94 -0.52 5.61e-24 Lobe attachment (rater-scored or self-reported); CRC cis rs35883536 0.647 rs17411209 chr1:101046734 A/G cg06223162 chr1:101003688 GPR88 -0.34 -6.11 -0.32 2.86e-9 Monocyte count; CRC cis rs7762018 0.514 rs60671539 chr6:170165981 A/G cg17545662 chr6:170176663 C6orf70 0.5 7.1 0.36 7.6e-12 Thiazide-induced adverse metabolic effects in hypertensive patients; CRC cis rs12586317 0.547 rs112510746 chr14:35491833 T/G cg05294307 chr14:35346193 BAZ1A -0.69 -7.47 -0.38 7.35e-13 Psoriasis; CRC cis rs12791968 0.765 rs12794846 chr11:44998943 C/T cg11846598 chr11:44996168 LOC221122 0.57 8.56 0.43 4.28e-16 Inhibitory control; CRC cis rs7647973 0.626 rs12715437 chr3:49751856 T/C cg03060546 chr3:49711283 APEH 0.65 7.89 0.4 4.56e-14 Menarche (age at onset); CRC cis rs863345 0.625 rs4609418 chr1:158464728 C/T cg12129480 chr1:158549410 OR10X1 -0.3 -6.35 -0.33 7.19e-10 Pneumococcal bacteremia; CRC cis rs4731207 0.698 rs4728012 chr7:124481798 C/T cg23710748 chr7:124431027 NA 0.38 6.08 0.32 3.42e-9 Cutaneous malignant melanoma; CRC cis rs9399137 0.507 rs4896129 chr6:135349845 C/T cg22676075 chr6:135203613 NA 0.59 8.91 0.44 3.49e-17 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; CRC cis rs7071206 0.740 rs2048781 chr10:79422975 T/C cg07817648 chr10:79422355 NA -0.66 -8.53 -0.43 5.24e-16 Bone mineral density; CRC cis rs2952156 0.920 rs732083 chr17:37834367 G/A cg20243544 chr17:37824526 PNMT 0.53 8.46 0.42 9.15e-16 Asthma; CRC cis rs4919694 1.000 rs78893207 chr10:104796138 T/C cg04362960 chr10:104952993 NT5C2 1.14 10.91 0.52 7.39e-24 Arsenic metabolism; CRC cis rs7618915 0.501 rs13060048 chr3:52598608 G/A cg05573699 chr3:52720067 GNL3;PBRM1 -0.44 -6.45 -0.34 3.94e-10 Bipolar disorder; CRC cis rs7463659 1.000 rs7836944 chr8:135436202 A/G cg09855544 chr8:135498122 ZFAT 0.4 6.2 0.32 1.72e-9 Colonoscopy-negative controls vs population controls; CRC cis rs853679 0.517 rs1340004 chr6:28103691 C/T cg12172441 chr6:28176163 NA 0.64 7.65 0.39 2.26e-13 Depression; CRC cis rs4242434 0.672 rs10110443 chr8:22484296 C/G cg03733263 chr8:22462867 KIAA1967 0.85 14.89 0.63 1.04e-38 Exploratory eye movement dysfunction in schizophrenia (cognitive search score); CRC cis rs10540 1.000 rs61876335 chr11:488878 T/C cg03576123 chr11:487126 PTDSS2 -0.89 -9.35 -0.46 1.38e-18 Body mass index; CRC cis rs875971 0.895 rs6460300 chr7:65952924 A/G cg12463550 chr7:65579703 CRCP 0.47 6.71 0.35 8.61e-11 Aortic root size; CRC cis rs2749592 0.550 rs7917262 chr10:37874602 A/C cg25427524 chr10:38739819 LOC399744 0.66 10.99 0.52 4e-24 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs4689388 0.889 rs13101355 chr4:6293446 T/C cg00701064 chr4:6280414 WFS1 0.75 13.24 0.59 2.22e-32 Type 2 diabetes and other traits;Type 2 diabetes; CRC cis rs10463316 0.817 rs13355052 chr5:150802003 A/G cg03212797 chr5:150827313 SLC36A1 -0.47 -7.13 -0.37 6.27e-12 Metabolite levels (Pyroglutamine); CRC cis rs28386778 0.897 rs1062791 chr17:61896487 C/T cg06873352 chr17:61820015 STRADA 0.77 14.46 0.62 5.18e-37 Prudent dietary pattern; CRC cis rs951366 0.789 rs823137 chr1:205738302 C/T cg14893161 chr1:205819251 PM20D1 0.82 13.07 0.58 9.67e-32 Menarche (age at onset); CRC trans rs10504229 1.000 rs56740825 chr8:58175617 A/G cg04077850 chr5:125800366 GRAMD3 0.37 6.27 0.33 1.15e-9 Developmental language disorder (linguistic errors); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg02375201 chr1:27114675 PIGV 0.41 6.39 0.33 5.61e-10 Liver disease severity in Alagille syndrome; CRC cis rs2836950 0.561 rs34705151 chr21:40553344 G/A cg11890956 chr21:40555474 PSMG1 -0.64 -9.6 -0.47 2.06e-19 Menarche (age at onset); CRC cis rs6500602 0.727 rs4238849 chr16:4538114 G/A cg14951292 chr16:4525986 HMOX2;NMRAL1 0.56 8.63 0.43 2.7e-16 Schizophrenia; CRC cis rs9783347 0.961 rs2061163 chr11:18322924 A/C cg15585147 chr11:18324498 HPS5 0.43 5.94 0.31 7.25e-9 Pancreatic cancer; CRC cis rs5769765 0.908 rs9616211 chr22:50317676 G/A cg22709217 chr22:50311962 ALG12;CRELD2 -1.05 -15.07 -0.64 2.18e-39 Schizophrenia; CRC cis rs17711722 0.701 rs781143 chr7:65439879 G/C cg05627663 chr7:65219948 SNORA22;CCT6P1 0.49 7.31 0.37 2.05e-12 Calcium levels; CRC trans rs564309 0.681 rs11581974 chr1:228617063 A/G cg24066601 chr6:26271455 HIST1H3G 0.6 6.81 0.35 4.66e-11 Hip circumference (psychosocial stress interaction); CRC cis rs6424115 1.000 rs7519554 chr1:24154566 T/A cg15997130 chr1:24165203 NA -0.76 -11.8 -0.55 5.07e-27 Immature fraction of reticulocytes; CRC cis rs10791097 0.694 rs4459316 chr11:130756176 T/C cg12179176 chr11:130786555 SNX19 0.74 12.34 0.56 5.26e-29 Autism spectrum disorder or schizophrenia;Schizophrenia; CRC cis rs7725052 0.609 rs4329064 chr5:40459315 A/G cg09067459 chr5:40385259 NA -0.4 -6.68 -0.35 9.91e-11 Pediatric autoimmune diseases; CRC cis rs7605827 0.897 rs11693457 chr2:15612683 A/C cg19274914 chr2:15703543 NA 0.39 5.95 0.31 6.89e-9 Educational attainment (years of education); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg17271592 chr1:149821902 HIST2H2AA4;HIST2H2AA3 0.45 6.63 0.34 1.41e-10 Liver disease severity in Alagille syndrome; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg25722142 chr6:139695762 CITED2 0.5 7.34 0.38 1.69e-12 Response to antipsychotic treatment; CRC cis rs73186030 0.920 rs73186050 chr3:122039928 C/T cg16331599 chr3:121796627 CD86 0.5 5.74 0.3 2.12e-8 Serum parathyroid hormone levels; CRC cis rs1129187 0.791 rs1129186 chr6:42932202 C/T cg26304593 chr6:42947056 PEX6 -0.45 -6.66 -0.34 1.13e-10 Alzheimer's disease in APOE e4+ carriers; CRC cis rs611744 0.517 rs62537573 chr8:109269281 C/T cg18478394 chr8:109455254 TTC35 0.42 6.24 0.33 1.36e-9 Dupuytren's disease; CRC cis rs11112613 0.775 rs12371537 chr12:105971425 T/C cg03607813 chr12:105948248 NA 0.78 10.1 0.49 4.44e-21 Corrected insulin response;Corrected insulin response adjusted for insulin sensitivity index; CRC cis rs2239547 0.618 rs4687663 chr3:52870618 T/A cg18404041 chr3:52824283 ITIH1 -0.41 -7.6 -0.39 3.03e-13 Schizophrenia; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg26361754 chr2:206790750 NA 0.43 6.91 0.36 2.5e-11 Liver disease severity in Alagille syndrome; CRC cis rs780096 0.526 rs780112 chr2:27665361 C/G cg27432699 chr2:27873401 GPN1 -0.51 -7.77 -0.39 9.82e-14 Total body bone mineral density; CRC cis rs11809207 0.523 rs2783706 chr1:26504697 A/G cg00147160 chr1:26503991 CNKSR1 0.29 6.03 0.32 4.48e-9 Height; CRC cis rs7618915 0.547 rs7642198 chr3:52677960 T/C cg18404041 chr3:52824283 ITIH1 -0.43 -8.82 -0.44 7.03e-17 Bipolar disorder; CRC cis rs7223966 0.921 rs34699959 chr17:61960720 T/G cg23090583 chr17:61904693 PSMC5;FTSJ3 0.46 5.74 0.3 2.17e-8 Hip circumference adjusted for BMI;Body mass index; CRC cis rs7131987 0.650 rs67146951 chr12:29450553 C/A cg09582351 chr12:29534625 ERGIC2 -0.34 -7.13 -0.37 6.56e-12 QT interval; CRC cis rs2204008 0.837 rs11183232 chr12:37941053 A/G cg13010199 chr12:38710504 ALG10B 0.46 6.04 0.32 4.06e-9 Bladder cancer; CRC cis rs7119 0.717 rs12909645 chr15:77816819 A/T cg10437265 chr15:77819839 NA 0.69 12.74 0.57 1.76e-30 Type 2 diabetes; CRC cis rs6840360 0.901 rs1561915 chr4:152479724 G/A cg09659197 chr4:152720779 NA 0.37 7.57 0.39 3.87e-13 Intelligence (multi-trait analysis); CRC cis rs1223397 1.000 rs1223399 chr6:13271220 G/A cg00460589 chr6:13274354 PHACTR1 0.45 5.61 0.3 4.39e-8 Blood pressure; CRC trans rs1005277 0.579 rs1740737 chr10:38499365 G/T cg11292332 chr7:45801988 SEPT13 -0.38 -6.71 -0.35 8.43e-11 Extrinsic epigenetic age acceleration; CRC cis rs9894429 0.683 rs112612275 chr17:79552604 C/A cg21984481 chr17:79567631 NPLOC4 0.57 10.74 0.51 2.98e-23 Eye color traits; CRC trans rs925098 0.577 rs2724470 chr4:17996046 A/G cg03864326 chr16:67927170 PSKH1 -0.41 -6.26 -0.33 1.17e-9 Birth weight;Height; CRC trans rs2749592 0.550 rs4934881 chr10:37914346 A/C cg17830980 chr10:43048298 ZNF37B 0.39 5.97 0.31 6.17e-9 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs208520 0.661 rs851466 chr6:66840476 A/G cg07460842 chr6:66804631 NA -1.1 -15.04 -0.64 2.83e-39 Exhaled nitric oxide output; CRC cis rs7044106 0.762 rs10760107 chr9:123383630 T/C cg09419670 chr9:123605666 PSMD5;LOC253039 0.69 10.72 0.51 3.43e-23 Hip circumference adjusted for BMI; CRC cis rs11971779 0.680 rs2355786 chr7:139065622 A/C cg23387468 chr7:139079360 LUC7L2 -0.4 -6.71 -0.35 8.39e-11 Diisocyanate-induced asthma; CRC cis rs2032447 0.899 rs1090947 chr6:26076642 T/C cg26028573 chr6:26043587 HIST1H2BB 0.45 6.54 0.34 2.41e-10 Intelligence (multi-trait analysis); CRC trans rs800082 0.698 rs800073 chr3:144347599 G/A cg24215973 chr2:240111563 HDAC4 -0.74 -10.24 -0.49 1.52e-21 Smoking behavior; CRC cis rs3096299 0.685 rs3803681 chr16:89544756 C/T cg00750074 chr16:89608354 SPG7 -0.47 -7.25 -0.37 2.96e-12 Multiple myeloma (IgH translocation); CRC cis rs875971 0.964 rs9691480 chr7:65944306 A/C cg18876405 chr7:65276391 NA 0.52 8.85 0.44 5.32e-17 Aortic root size; CRC cis rs853679 0.882 rs9468287 chr6:28079741 G/T cg15786705 chr6:28176104 NA 0.7 5.73 0.3 2.25e-8 Depression; CRC cis rs73206853 0.841 rs4131850 chr12:110812553 G/A cg12870014 chr12:110450643 ANKRD13A 0.77 8.38 0.42 1.59e-15 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC cis rs652260 0.967 rs667295 chr19:7901634 G/A cg26014689 chr19:7917955 EVI5L -0.53 -8.68 -0.43 1.88e-16 Menarche (age at onset); CRC cis rs4718428 0.607 rs66954441 chr7:66369209 T/C cg18252515 chr7:66147081 NA -0.55 -7.66 -0.39 2.1e-13 Corneal structure; CRC cis rs9463078 0.683 rs227855 chr6:44702352 T/C cg25276700 chr6:44698697 NA 0.26 6.06 0.32 3.79e-9 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; CRC cis rs6163 0.508 rs12776506 chr10:104532828 A/G cg11453585 chr10:104263688 ACTR1A;SUFU -0.49 -5.84 -0.31 1.24e-8 Waist circumference;Hip circumference; CRC cis rs7809950 0.815 rs62482495 chr7:106965009 A/G cg23024343 chr7:107201750 COG5 -0.74 -10.07 -0.49 5.75e-21 Coronary artery disease; CRC cis rs10256972 0.552 rs2960830 chr7:1200641 T/C cg07092213 chr7:1199455 ZFAND2A -0.49 -7.1 -0.36 7.72e-12 Longevity;Endometriosis; CRC cis rs801193 0.660 rs974239 chr7:66213491 G/A cg11764359 chr7:65958608 NA 0.6 9.22 0.45 3.61e-18 Aortic root size; CRC cis rs6502050 0.799 rs4789680 chr17:80100547 C/A cg13198984 chr17:80129470 CCDC57 0.46 8.16 0.41 6.94e-15 Life satisfaction; CRC cis rs7208859 0.524 rs8065744 chr17:29099449 C/T cg01831904 chr17:28903510 LRRC37B2 -0.63 -6.45 -0.33 4.07e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs9549367 0.662 rs3818334 chr13:113825174 C/G cg18105134 chr13:113819100 PROZ -0.85 -12.45 -0.57 2.12e-29 Platelet distribution width; CRC cis rs863345 0.584 rs6672789 chr1:158497139 T/C cg12129480 chr1:158549410 OR10X1 -0.29 -5.9 -0.31 8.89e-9 Pneumococcal bacteremia; CRC cis rs1707322 1.000 rs10890355 chr1:46317348 G/A cg03146154 chr1:46216737 IPP 0.5 7.0 0.36 1.43e-11 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs1570884 0.516 rs9526580 chr13:50164023 C/G cg03651054 chr13:50194643 NA -0.33 -6.74 -0.35 7.19e-11 Sum basophil neutrophil counts;Sum neutrophil eosinophil counts;Neutrophil count;Myeloid white cell count;Granulocyte count; CRC cis rs11997175 0.574 rs872489 chr8:33646401 T/C ch.8.33884649F chr8:33765107 NA 0.47 7.45 0.38 8.11e-13 Body mass index; CRC cis rs478304 0.934 rs498354 chr11:65528213 A/G cg08755490 chr11:65554678 OVOL1 0.44 6.34 0.33 7.57e-10 Acne (severe); CRC cis rs763121 0.853 rs4821810 chr22:39072098 C/G cg06544989 chr22:39130855 UNC84B 0.47 7.52 0.38 5.37e-13 Menopause (age at onset); CRC cis rs72634258 0.554 rs4908704 chr1:7918904 A/G cg26816564 chr1:7831052 VAMP3 0.77 8.93 0.44 3.06e-17 Inflammatory bowel disease; CRC cis rs11252926 0.931 rs12358336 chr10:566981 A/T cg18196295 chr10:418757 DIP2C -0.54 -7.37 -0.38 1.35e-12 Psychosis in Alzheimer's disease; CRC cis rs12497850 0.627 rs4974078 chr3:49009386 C/T cg07636037 chr3:49044803 WDR6 0.63 9.73 0.47 8.1e-20 Parkinson's disease; CRC cis rs12142240 0.698 rs1053627 chr1:46827728 A/C cg00530320 chr1:46809349 NSUN4 0.59 8.03 0.41 1.69e-14 Menopause (age at onset); CRC cis rs9814567 0.806 rs9839705 chr3:134323819 T/C cg06541857 chr3:134203789 ANAPC13;CEP63 -0.37 -5.71 -0.3 2.47e-8 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg07618626 chr3:32726534 CNOT10 0.4 6.17 0.32 1.96e-9 Intelligence (multi-trait analysis); CRC cis rs7172677 0.731 rs1108059 chr15:75338890 A/C cg14664628 chr15:75095509 CSK 0.55 6.56 0.34 2.12e-10 Systemic lupus erythematosus and Systemic sclerosis; CRC cis rs780096 0.526 rs1647276 chr2:27688601 C/T cg24768116 chr2:27665128 KRTCAP3 -0.36 -8.12 -0.41 9.76e-15 Total body bone mineral density; CRC cis rs798554 0.724 rs798498 chr7:2795882 T/G cg19346786 chr7:2764209 NA -0.37 -6.71 -0.35 8.71e-11 Height; CRC cis rs13118159 0.505 rs1250128 chr4:1257311 T/C cg02018176 chr4:1364513 KIAA1530 -0.7 -11.49 -0.53 6.66e-26 Longevity; CRC cis rs1355223 0.583 rs2941058 chr11:34880245 C/G cg11058730 chr11:34937778 PDHX;APIP 0.71 11.31 0.53 2.9e-25 Systemic lupus erythematosus and Systemic sclerosis; CRC cis rs10791097 0.702 rs10894267 chr11:130714861 C/T cg12179176 chr11:130786555 SNX19 -0.51 -7.81 -0.4 7.57e-14 Autism spectrum disorder or schizophrenia;Schizophrenia; CRC cis rs798554 0.836 rs798500 chr7:2790685 C/T cg17321639 chr7:2759063 NA 0.53 7.26 0.37 2.75e-12 Height; CRC cis rs12594515 1.000 rs6493167 chr15:45986809 G/A cg01629716 chr15:45996671 NA 0.41 8.5 0.42 6.75e-16 Waist circumference;Weight; CRC cis rs4713118 0.662 rs9357060 chr6:28024486 C/G cg02683197 chr6:28174875 NA 0.75 9.84 0.48 3.43e-20 Parkinson's disease; CRC cis rs9818758 0.607 rs34326553 chr3:49134429 A/G cg00383909 chr3:49044727 WDR6 1.27 12.24 0.56 1.19e-28 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; CRC trans rs6561151 0.681 rs17653353 chr13:44421746 A/G cg12856521 chr11:46389249 DGKZ 0.76 10.57 0.5 1.14e-22 Crohn's disease; CRC cis rs7727544 0.507 rs9791170 chr5:131569627 A/G cg09877947 chr5:131593287 PDLIM4 0.51 9.4 0.46 9.88e-19 Blood metabolite levels; CRC cis rs77633900 0.614 rs280024 chr15:77034518 A/C cg21673338 chr15:77095150 SCAPER -0.73 -7.46 -0.38 7.68e-13 Non-glioblastoma glioma;Glioma; CRC cis rs1451375 0.959 rs6962356 chr7:50621941 T/C cg14593290 chr7:50529359 DDC 0.49 7.1 0.36 7.86e-12 Malaria; CRC cis rs4819052 0.851 rs2838858 chr21:46681093 T/A cg19498844 chr21:46707878 POFUT2;LOC642852 0.76 10.96 0.52 4.92e-24 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs861020 0.606 rs689210 chr1:210013723 A/C cg09163369 chr1:210001066 C1orf107 0.41 5.79 0.3 1.68e-8 Orofacial clefts; CRC cis rs4713118 0.540 rs469227 chr6:27970705 A/C cg06470822 chr6:28175283 NA 0.84 12.77 0.58 1.28e-30 Parkinson's disease; CRC trans rs2243480 1.000 rs781156 chr7:65479141 C/A cg10756647 chr7:56101905 PSPH 0.74 7.95 0.4 3.07e-14 Diabetic kidney disease; CRC cis rs172166 0.694 rs203884 chr6:28077374 G/T cg15845792 chr6:28175446 NA 0.76 11.21 0.53 6.42e-25 Cardiac Troponin-T levels; CRC cis rs7119 0.717 rs12904212 chr15:77815833 C/A cg10437265 chr15:77819839 NA 0.69 12.72 0.57 1.96e-30 Type 2 diabetes; CRC cis rs7772486 0.764 rs2265471 chr6:146220250 G/A cg13319975 chr6:146136371 FBXO30 -0.38 -5.8 -0.3 1.54e-8 Lobe attachment (rater-scored or self-reported); CRC cis rs7178572 0.962 rs1022172 chr15:77793359 A/G cg22256960 chr15:77711686 NA -0.7 -10.78 -0.51 2.14e-23 Type 2 diabetes; CRC cis rs10504229 0.683 rs16921808 chr8:58106049 C/T cg21724239 chr8:58056113 NA 0.56 7.33 0.37 1.82e-12 Developmental language disorder (linguistic errors); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg14363996 chr9:140122076 NA 0.4 6.17 0.32 2.03e-9 Liver disease severity in Alagille syndrome; CRC cis rs11792861 0.926 rs72607163 chr9:111803128 G/T cg05043794 chr9:111880884 C9orf5 -0.35 -6.44 -0.33 4.2e-10 Menarche (age at onset); CRC cis rs4728302 0.643 rs2346442 chr7:133705907 A/G cg03336402 chr7:133662267 EXOC4 0.44 6.7 0.35 9.23e-11 Intelligence;Intelligence (multi-trait analysis); CRC cis rs7586879 0.789 rs13398155 chr2:25128550 C/T cg22495460 chr2:25135724 ADCY3 -0.89 -15.38 -0.65 1.29e-40 Body mass index; CRC cis rs6499255 0.857 rs11643926 chr16:69807282 A/G cg00738113 chr16:70207722 CLEC18C -0.43 -6.2 -0.32 1.7e-9 IgE levels; CRC cis rs6500602 0.702 rs3789038 chr16:4546586 C/G cg14951292 chr16:4525986 HMOX2;NMRAL1 -0.55 -8.06 -0.41 1.43e-14 Schizophrenia; CRC trans rs2832077 0.527 rs1048546 chr21:30244877 G/T cg14791747 chr16:20752902 THUMPD1 0.64 10.02 0.48 8.38e-21 Cognitive test performance; CRC trans rs7726839 0.561 rs4957048 chr5:583442 G/A cg25482853 chr8:67687455 SGK3 1.01 12.23 0.56 1.32e-28 Obesity-related traits; CRC cis rs7113874 0.589 rs7112153 chr11:8461178 T/C cg17679104 chr11:8615758 STK33 -0.34 -5.67 -0.3 3.16e-8 Body mass index in physically active individuals;Body mass index (joint analysis main effects and physical activity interaction); CRC trans rs2243480 1.000 rs316331 chr7:65604622 A/G cg10756647 chr7:56101905 PSPH -0.69 -7.26 -0.37 2.75e-12 Diabetic kidney disease; CRC cis rs11122272 0.735 rs2739507 chr1:231527329 T/C cg06096015 chr1:231504339 EGLN1 0.38 5.77 0.3 1.84e-8 Hemoglobin concentration; CRC cis rs2019216 1.000 rs3751916 chr17:21909270 T/C cg05591447 chr17:21909280 FLJ36000 -0.35 -7.08 -0.36 8.78e-12 Pelvic organ prolapse; CRC cis rs2576037 0.583 rs512699 chr18:44374681 C/T cg19077165 chr18:44547161 KATNAL2 0.6 9.71 0.47 9.1e-20 Personality dimensions; CRC cis rs10751667 0.961 rs7480178 chr11:927108 T/C cg23136738 chr11:925521 AP2A2 -0.5 -7.94 -0.4 3.32e-14 Alzheimer's disease (late onset); CRC cis rs769267 1.000 rs1009136 chr19:19440428 A/G cg03709012 chr19:19516395 GATAD2A -0.67 -10.33 -0.49 7.45e-22 Tonsillectomy; CRC cis rs8180040 1.000 rs1024037 chr3:47318449 C/A cg10298567 chr3:47292165 KIF9 0.45 7.26 0.37 2.8e-12 Colorectal cancer; CRC cis rs1865760 0.568 rs2032450 chr6:25993114 C/G cg18357526 chr6:26021779 HIST1H4A 0.39 5.6 0.3 4.47e-8 Height; CRC cis rs3785574 0.962 rs2584621 chr17:61912436 G/A cg06601766 chr17:61851465 DDX42;CCDC47 0.6 8.36 0.42 1.76e-15 Height; CRC cis rs13161895 1.000 rs12654148 chr5:179438920 T/A cg02702477 chr5:179499311 RNF130 -0.56 -6.48 -0.34 3.35e-10 LDL cholesterol; CRC trans rs1814175 0.645 rs28447324 chr11:50046629 C/A cg15704280 chr7:45808275 SEPT13 -0.93 -17.08 -0.69 2.88e-47 Height; CRC cis rs8180040 0.620 rs1811652 chr3:47208698 C/G cg27129171 chr3:47204927 SETD2 -0.72 -11.38 -0.53 1.64e-25 Colorectal cancer; CRC cis rs6840360 0.571 rs11932059 chr4:152524496 G/A cg09659197 chr4:152720779 NA 0.32 5.75 0.3 2.09e-8 Intelligence (multi-trait analysis); CRC cis rs12142240 0.659 rs72677602 chr1:46837487 G/A cg14993813 chr1:46806288 NSUN4 -0.51 -6.3 -0.33 9.65e-10 Menopause (age at onset); CRC trans rs6951245 0.935 rs61753396 chr7:1105372 A/G cg13565492 chr6:43139072 SRF -0.72 -7.5 -0.38 6.06e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs6951245 1.000 rs77868187 chr7:1093968 A/C cg24642844 chr7:1081250 C7orf50 -0.78 -9.47 -0.46 5.57e-19 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs2404602 0.735 rs11635463 chr15:76762986 C/T cg23625390 chr15:77176239 SCAPER -0.84 -12.73 -0.57 1.79e-30 Blood metabolite levels; CRC trans rs853679 0.882 rs9468287 chr6:28079741 G/T cg06606381 chr12:133084897 FBRSL1 -0.99 -8.2 -0.41 5.29e-15 Depression; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg27304813 chr3:120068385 LRRC58 0.46 6.66 0.34 1.14e-10 Response to antipsychotic treatment; CRC cis rs2857078 0.654 rs4793083 chr17:42312973 C/T cg09913183 chr17:42254507 C17orf65;ASB16 -0.39 -5.6 -0.3 4.46e-8 Red cell distribution width;Reticulocyte count; CRC cis rs45430 1.000 rs443099 chr21:42743327 G/T cg06102954 chr21:42741788 MX2 0.4 6.12 0.32 2.64e-9 Melanoma; CRC cis rs7586879 1.000 rs6736711 chr2:25116456 C/T cg22495460 chr2:25135724 ADCY3 -0.73 -11.97 -0.55 1.19e-27 Body mass index; CRC cis rs2032447 0.839 rs9356995 chr6:25996673 G/A cg12310025 chr6:25882481 NA -0.49 -6.85 -0.35 3.62e-11 Intelligence (multi-trait analysis); CRC cis rs17376456 0.877 rs10076052 chr5:93317762 C/T cg09848695 chr5:92956644 FAM172A;MIR2277 0.63 5.67 0.3 3.18e-8 Diabetic retinopathy; CRC cis rs8077889 0.956 rs4793025 chr17:41841621 T/C cg26893861 chr17:41843967 DUSP3 1.0 13.1 0.59 7.92e-32 Triglycerides; CRC cis rs12692738 0.526 rs355858 chr2:165629457 G/A cg03182029 chr2:165697222 COBLL1 0.5 5.86 0.31 1.11e-8 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);Waist-to-hip ratio adjusted for BMI in non-smokers;Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction);Waist-to-hip ratio adjusted for body mass index; CRC cis rs1150668 0.745 rs213238 chr6:28321993 T/C cg12273811 chr6:28175739 NA 0.39 5.67 0.3 3.06e-8 Pubertal anthropometrics; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg10513276 chr9:115095793 ROD1 0.44 6.2 0.32 1.67e-9 Response to antipsychotic treatment; CRC cis rs9611565 0.512 rs45500192 chr22:42177899 A/G cg03806693 chr22:41940476 POLR3H -1.08 -12.78 -0.58 1.17e-30 Vitiligo; CRC cis rs8031584 0.672 rs17815726 chr15:31313252 C/G cg08109568 chr15:31115862 NA 0.48 6.24 0.33 1.33e-9 Huntington's disease progression; CRC cis rs62064224 0.597 rs7207268 chr17:30725155 T/G cg12855166 chr17:30846586 MYO1D -0.34 -5.65 -0.3 3.48e-8 Schizophrenia; CRC cis rs4665809 0.531 rs12990692 chr2:26464939 C/T cg08067268 chr2:26466485 HADHB;HADHA 0.64 8.33 0.42 2.17e-15 Gut microbiome composition (summer); CRC cis rs7249142 0.549 rs72997174 chr19:19294389 T/C cg26504305 chr19:19281019 LOC729991-MEF2B;MEF2B -0.44 -8.75 -0.43 1.16e-16 IgG glycosylation; CRC cis rs3018066 0.589 rs6835216 chr4:107027530 G/T cg01869342 chr4:106983673 TBCK 0.42 5.65 0.3 3.5e-8 Cancer; CRC cis rs11657217 0.677 rs8071194 chr17:77698458 A/C cg06901238 chr17:77706717 ENPP7 0.4 6.55 0.34 2.25e-10 Diastolic blood pressure response to hydrochlorothiazide in hypertension; CRC cis rs2857891 0.909 rs56026267 chr11:6940211 T/C cg17958423 chr11:6947583 ZNF215 0.58 6.08 0.32 3.27e-9 Response to cytadine analogues (cytosine arabinoside); CRC cis rs3936840 0.548 rs1190545 chr14:102904179 G/C cg18135206 chr14:102964638 TECPR2 -0.53 -6.67 -0.35 1.08e-10 Plateletcrit; CRC cis rs7937682 0.632 rs11214029 chr11:111761230 C/T cg19812747 chr11:111475976 SIK2 0.43 6.09 0.32 3.18e-9 Primary sclerosing cholangitis; CRC cis rs11792861 0.564 rs3816237 chr9:111718348 T/A cg14432460 chr9:111696404 IKBKAP;C9orf6 0.52 7.36 0.38 1.51e-12 Menarche (age at onset); CRC cis rs1799949 1.000 rs35070007 chr17:41316747 C/G cg05368731 chr17:41323189 NBR1 -0.62 -9.48 -0.46 5.06e-19 Menopause (age at onset); CRC cis rs72717009 0.825 rs12746613 chr1:161467042 A/G cg23840854 chr1:161414152 NA 0.68 7.89 0.4 4.43e-14 Rheumatoid arthritis; CRC cis rs7843479 0.601 rs10453141 chr8:21847235 T/C cg16476235 chr8:21771668 DOK2 0.43 7.31 0.37 2.03e-12 Mean corpuscular volume; CRC cis rs7224685 0.501 rs2054038 chr17:4014391 A/C cg10724054 chr17:3904396 NA -0.38 -6.1 -0.32 2.91e-9 Type 2 diabetes; CRC cis rs9902453 0.904 rs7219456 chr17:28374112 A/G cg26525008 chr17:28256777 EFCAB5;SSH2 -0.69 -11.35 -0.53 2.01e-25 Coffee consumption (cups per day); CRC cis rs17826219 0.561 rs4085382 chr17:29071202 T/C cg01831904 chr17:28903510 LRRC37B2 -0.56 -6.37 -0.33 6.29e-10 Body mass index; CRC cis rs9487051 0.714 rs7774390 chr6:109602461 C/G cg21918786 chr6:109611834 NA 0.41 7.23 0.37 3.42e-12 Reticulocyte fraction of red cells; CRC cis rs7666738 0.830 rs7662114 chr4:99019985 A/G cg17366294 chr4:99064904 C4orf37 0.43 7.29 0.37 2.28e-12 Colonoscopy-negative controls vs population controls; CRC cis rs3858526 0.584 rs10734560 chr11:5864503 G/T cg02574844 chr11:5959923 NA -0.5 -7.15 -0.37 5.75e-12 DNA methylation (variation); CRC cis rs6570726 0.935 rs365658 chr6:145844588 C/T cg23711669 chr6:146136114 FBXO30 0.69 12.31 0.56 6.55e-29 Lobe attachment (rater-scored or self-reported); CRC cis rs875971 0.619 rs10278371 chr7:66051540 C/A cg00343986 chr7:65444356 GUSB -0.52 -7.77 -0.39 1.01e-13 Aortic root size; CRC cis rs4713118 0.621 rs4713133 chr6:28034041 T/C cg02631126 chr6:28058918 ZSCAN12L1 0.28 5.95 0.31 6.79e-9 Parkinson's disease; CRC trans rs1814175 0.645 rs847632 chr11:49926097 C/T cg11707556 chr5:10655725 ANKRD33B -0.51 -9.64 -0.47 1.6e-19 Height; CRC cis rs3858526 0.959 rs1840179 chr11:5949148 A/G cg02574844 chr11:5959923 NA -0.46 -6.47 -0.34 3.55e-10 DNA methylation (variation); CRC cis rs17270561 0.609 rs12192077 chr6:25732794 G/A cg17691542 chr6:26056736 HIST1H1C 0.73 9.26 0.45 2.71e-18 Iron status biomarkers; CRC cis rs6088580 0.601 rs6059872 chr20:33082775 C/A cg08999081 chr20:33150536 PIGU 0.63 11.53 0.54 4.68e-26 Glomerular filtration rate (creatinine); CRC cis rs7178572 0.568 rs12909924 chr15:77551445 T/G cg22256960 chr15:77711686 NA -0.66 -9.68 -0.47 1.16e-19 Type 2 diabetes; CRC cis rs6694672 1.000 rs4915345 chr1:197102839 A/C cg13682187 chr1:196946512 CFHR5 0.51 8.05 0.41 1.55e-14 Asthma; CRC cis rs17601876 0.814 rs749292 chr15:51558731 A/G cg19946085 chr15:51559439 CYP19A1 0.35 7.18 0.37 4.68e-12 Estrone/androstenedione ratio in resected early stage-receptor positive breast cancer; CRC cis rs2251381 0.750 rs2251186 chr21:30528880 G/A cg08807101 chr21:30365312 RNF160 0.67 10.07 0.49 5.84e-21 Selective IgA deficiency; CRC cis rs35883536 0.647 rs2809790 chr1:101040461 C/T cg06223162 chr1:101003688 GPR88 0.34 6.32 0.33 8.46e-10 Monocyte count; CRC cis rs11105298 0.891 rs10858902 chr12:89927789 A/G cg08166232 chr12:89918718 WDR51B;GALNT4 -0.61 -7.63 -0.39 2.57e-13 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; CRC cis rs2832191 0.903 rs11700687 chr21:30486767 A/G cg24692254 chr21:30365293 RNF160 -0.65 -11.2 -0.53 7.06e-25 Dental caries; CRC cis rs11105298 0.891 rs10858881 chr12:89891474 T/G cg00757033 chr12:89920650 WDR51B 0.39 6.64 0.34 1.32e-10 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; CRC cis rs3091242 0.933 rs7541095 chr1:25761291 T/C cg20684491 chr1:25596433 NA 0.42 7.3 0.37 2.18e-12 Erythrocyte sedimentation rate; CRC cis rs12711979 1.000 rs12711979 chr2:3869559 A/G cg17052675 chr2:3827356 NA -0.49 -8.77 -0.44 9.49e-17 Itch intensity from mosquito bite adjusted by bite size; CRC cis rs780096 0.526 rs7602534 chr2:27592423 C/T cg24768116 chr2:27665128 KRTCAP3 -0.33 -7.34 -0.38 1.64e-12 Total body bone mineral density; CRC trans rs931812 0.757 rs13251801 chr8:101902629 A/T cg20993868 chr7:22813445 NA 0.45 9.02 0.45 1.59e-17 Attention deficit hyperactivity disorder and conduct disorder; CRC cis rs73001065 0.591 rs57962361 chr19:19425025 C/T cg03709012 chr19:19516395 GATAD2A 0.84 6.81 0.35 4.55e-11 LDL cholesterol; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg04100492 chr1:1677730 SLC35E2 0.4 6.1 0.32 2.93e-9 Liver disease severity in Alagille syndrome; CRC cis rs55665837 0.559 rs9667144 chr11:14421101 C/T cg19336497 chr11:14380999 RRAS2 0.43 7.41 0.38 1.1e-12 Vitamin D levels; CRC cis rs2857891 0.697 rs1004754 chr11:6946248 T/C cg04053776 chr11:6947353 ZNF215 0.51 6.83 0.35 4.14e-11 Response to cytadine analogues (cytosine arabinoside); CRC cis rs6696846 0.777 rs2369526 chr1:205054406 C/T cg00857998 chr1:205179979 DSTYK 0.41 5.85 0.31 1.19e-8 Red blood cell count; CRC cis rs7829975 0.623 rs10092965 chr8:8373485 A/G cg06636001 chr8:8085503 FLJ10661 0.54 8.12 0.41 9.18e-15 Mood instability; CRC cis rs17376456 0.825 rs13155452 chr5:93164449 C/T cg09848695 chr5:92956644 FAM172A;MIR2277 -0.71 -6.7 -0.35 9.32e-11 Diabetic retinopathy; CRC cis rs769267 0.930 rs892022 chr19:19613381 G/A cg03709012 chr19:19516395 GATAD2A 0.72 11.17 0.52 8.58e-25 Tonsillectomy; CRC trans rs1814175 0.669 rs17472879 chr11:49499520 G/T cg15704280 chr7:45808275 SEPT13 -0.72 -11.59 -0.54 2.88e-26 Height; CRC cis rs769267 1.000 rs3764567 chr19:19440066 C/T cg01262667 chr19:19385393 TM6SF2 -0.37 -5.89 -0.31 9.5e-9 Tonsillectomy; CRC cis rs3772130 0.583 rs34051021 chr3:121433005 C/A cg20356878 chr3:121714668 ILDR1 0.56 10.13 0.49 3.62e-21 Cognitive performance; CRC cis rs1005277 0.579 rs2474569 chr10:38383491 C/G cg17219203 chr10:38645113 HSD17B7P2 -0.41 -5.76 -0.3 1.89e-8 Extrinsic epigenetic age acceleration; CRC cis rs4237845 0.773 rs6650217 chr12:58289072 T/G cg02175503 chr12:58329896 NA 0.59 8.32 0.42 2.29e-15 Intelligence (multi-trait analysis); CRC cis rs7177699 0.557 rs7178051 chr15:79118296 A/G cg15571903 chr15:79123663 NA 0.31 5.98 0.31 5.95e-9 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; CRC cis rs12762955 0.561 rs10752022 chr10:1043798 C/T cg20503657 chr10:835505 NA -0.48 -6.64 -0.34 1.3e-10 Response to angiotensin II receptor blocker therapy; CRC cis rs7659604 0.935 rs73844280 chr4:122664687 G/A cg20573242 chr4:122745356 CCNA2 0.41 6.14 0.32 2.4e-9 Type 2 diabetes; CRC cis rs4665809 0.627 rs13014338 chr2:26463024 C/T cg27170947 chr2:26402098 FAM59B 0.59 7.71 0.39 1.53e-13 Gut microbiome composition (summer); CRC cis rs13082711 0.911 rs11709954 chr3:27421427 C/T cg02860705 chr3:27208620 NA 0.61 8.36 0.42 1.83e-15 Systolic blood pressure;Diastolic blood pressure;Blood pressure; CRC cis rs7223966 1.000 rs8064261 chr17:61705212 G/A cg05941027 chr17:61774174 LIMD2 0.35 6.44 0.33 4.13e-10 Hip circumference adjusted for BMI;Body mass index; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg19936585 chr2:139259770 SPOPL -0.4 -6.1 -0.32 2.94e-9 Myopia (pathological); CRC cis rs10106298 1.000 rs17773903 chr8:103685172 A/G cg10187029 chr8:103597600 NA 0.48 6.65 0.34 1.23e-10 Schizophrenia; CRC cis rs2050392 0.931 rs2265187 chr10:30690844 C/T cg18806716 chr10:30721971 MAP3K8 -0.48 -7.12 -0.37 6.73e-12 Inflammatory bowel disease; CRC cis rs11098499 0.954 rs6847248 chr4:120225955 A/G cg24375607 chr4:120327624 NA 0.51 7.38 0.38 1.28e-12 Corneal astigmatism; CRC cis rs3736594 0.513 rs62138971 chr2:27840754 G/A cg27432699 chr2:27873401 GPN1 0.62 8.05 0.41 1.56e-14 Fasting blood glucose;Fasting blood glucose (BMI interaction); CRC cis rs11122272 0.735 rs2437148 chr1:231513979 A/G cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.54 -8.11 -0.41 1.04e-14 Hemoglobin concentration; CRC trans rs67073037 0.955 rs12620680 chr2:29144611 C/T cg13899017 chr1:159158444 CADM3 -0.36 -6.09 -0.32 3.16e-9 Breast cancer;Breast cancer (estrogen-receptor negative); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg00039960 chr17:7142925 PHF23 0.4 6.1 0.32 3.01e-9 Intelligence (multi-trait analysis); CRC cis rs17666538 0.539 rs1703925 chr8:608279 A/G cg26554054 chr8:600488 NA 0.61 5.8 0.3 1.56e-8 IgG glycosylation; CRC trans rs2797160 1.000 rs1777225 chr6:126018270 T/C cg05039488 chr6:79577232 IRAK1BP1 0.5 7.47 0.38 7.32e-13 Endometrial cancer; CRC cis rs76419734 0.510 rs6820671 chr4:106613821 A/G cg24545054 chr4:106630052 GSTCD;INTS12 0.59 7.21 0.37 3.77e-12 Post bronchodilator FEV1; CRC cis rs2279817 0.913 rs2270979 chr1:18023290 C/T cg21791023 chr1:18019539 ARHGEF10L 0.47 5.98 0.31 5.87e-9 Neuroticism; CRC cis rs2836974 0.897 rs7280375 chr21:40552408 C/T cg11890956 chr21:40555474 PSMG1 -1.07 -18.43 -0.71 1.27e-52 Cognitive function; CRC cis rs6502050 0.805 rs7225560 chr17:80160884 C/G cg19223190 chr17:80058835 NA 0.41 6.62 0.34 1.5e-10 Life satisfaction; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg14239635 chr6:116892067 RWDD1 0.46 6.56 0.34 2.06e-10 Response to antipsychotic treatment; CRC cis rs1348850 0.747 rs1047884 chr2:178488281 C/G cg02961200 chr2:178257176 LOC100130691;AGPS 0.51 7.28 0.37 2.5e-12 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs531930 1.000 rs486550 chr6:124738091 A/G cg05308643 chr6:124982296 NKAIN2 -0.42 -5.81 -0.3 1.49e-8 Celiac disease; CRC cis rs561341 1.000 rs473356 chr17:30321762 G/C cg19193384 chr17:30244184 NA -0.65 -7.57 -0.39 3.82e-13 Hip circumference adjusted for BMI; CRC cis rs7726839 0.574 rs11134149 chr5:637277 A/G cg09021430 chr5:549028 NA -0.7 -8.66 -0.43 2.15e-16 Obesity-related traits; CRC trans rs10504229 1.000 rs67236942 chr8:58176525 T/C cg04077850 chr5:125800366 GRAMD3 0.37 6.27 0.33 1.15e-9 Developmental language disorder (linguistic errors); CRC cis rs10504229 0.595 rs116490935 chr8:58117531 A/G cg02725872 chr8:58115012 NA -0.65 -11.45 -0.53 8.72e-26 Developmental language disorder (linguistic errors); CRC cis rs6496667 0.779 rs2074581 chr15:91009147 T/G cg04176472 chr15:90893244 GABARAPL3 0.53 7.5 0.38 6.06e-13 Rheumatoid arthritis; CRC cis rs2289583 0.500 rs67168917 chr15:75391494 G/T cg18612461 chr15:75251733 NA -0.38 -5.99 -0.31 5.64e-9 Systemic lupus erythematosus; CRC cis rs2302729 0.545 rs10161275 chr12:2771018 A/G cg19945202 chr12:2788847 CACNA1C -0.44 -7.21 -0.37 3.94e-12 Sleep quality; CRC cis rs6582630 0.539 rs8189604 chr12:38308546 G/T cg26384229 chr12:38710491 ALG10B -0.53 -7.69 -0.39 1.72e-13 Drug-induced liver injury (flucloxacillin); CRC trans rs6600671 0.967 rs4844613 chr1:121173773 T/C cg09829573 chr1:144692074 NBPF9 -0.41 -6.29 -0.33 9.83e-10 Hip geometry; CRC cis rs9868809 0.772 rs9841602 chr3:48713570 A/G cg00383909 chr3:49044727 WDR6 0.62 6.51 0.34 2.8e-10 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; CRC cis rs4975709 0.589 rs4975745 chr5:1861058 G/C cg11168104 chr5:1857477 NA -0.38 -6.63 -0.34 1.42e-10 Cardiovascular disease risk factors; CRC cis rs9443645 0.527 rs9359360 chr6:79702796 C/T cg05283184 chr6:79620031 NA -0.45 -6.45 -0.34 3.91e-10 Intelligence (multi-trait analysis); CRC cis rs9914988 0.887 rs11656272 chr17:27091153 A/G cg02049041 chr17:27085579 C17orf63 0.44 5.61 0.3 4.31e-8 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs3996993 0.597 rs55906003 chr6:52733927 C/T cg20803780 chr6:52668592 GSTA1 0.39 7.0 0.36 1.47e-11 Hemoglobin concentration; CRC cis rs7666738 0.830 rs10470893 chr4:99038756 C/T cg05340658 chr4:99064831 C4orf37 0.6 9.45 0.46 6.36e-19 Colonoscopy-negative controls vs population controls; CRC cis rs3862260 0.509 rs2281493 chr1:120162787 T/C cg16322792 chr1:120165303 ZNF697 0.48 8.45 0.42 9.27e-16 Systemic lupus erythematosus; CRC cis rs7662987 0.517 rs1154405 chr4:100008750 G/A cg12011299 chr4:100065546 ADH4 0.49 9.18 0.45 4.86e-18 Smoking initiation; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg17157516 chr1:35332203 DLGAP3 0.43 6.2 0.32 1.73e-9 Response to antipsychotic treatment; CRC cis rs11229555 0.645 rs4517537 chr11:58213695 G/A cg15696309 chr11:58395628 NA -0.82 -10.31 -0.49 8.59e-22 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; CRC cis rs4803468 0.967 rs7259900 chr19:41889429 A/T cg09537434 chr19:41945824 ATP5SL -0.96 -17.68 -0.7 1.16e-49 Height; CRC cis rs929596 0.614 rs10929302 chr2:234665782 G/A cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.73 -10.71 -0.51 3.59e-23 Total bilirubin levels in HIV-1 infection; CRC cis rs11608355 0.545 rs11609019 chr12:109895958 G/A cg05360138 chr12:110035743 NA 0.77 8.7 0.43 1.65e-16 Neuroticism; CRC trans rs4263408 0.934 rs9683743 chr4:39703194 A/C cg10622236 chr15:42120082 JMJD7;JMJD7-PLA2G4B -0.43 -6.39 -0.33 5.72e-10 Plasma amyloid beta peptide concentrations (ABx-40); CRC cis rs117623576 0.680 rs12269122 chr10:32367864 C/T cg03047570 chr10:32398778 NA -0.62 -6.92 -0.36 2.39e-11 Anti-saccade response; CRC cis rs172166 0.694 rs536704 chr6:28092603 T/G cg20615401 chr6:28092323 ZSCAN16 0.47 6.27 0.33 1.16e-9 Cardiac Troponin-T levels; CRC cis rs1355223 0.934 rs5010670 chr11:34766649 A/C cg11058730 chr11:34937778 PDHX;APIP -0.44 -6.25 -0.33 1.28e-9 Systemic lupus erythematosus and Systemic sclerosis; CRC cis rs13108904 0.518 rs4974602 chr4:1342391 C/T cg21620606 chr4:1342894 KIAA1530 0.5 8.16 0.41 7.39e-15 Obesity-related traits; CRC cis rs2836974 0.932 rs6517526 chr21:40581530 T/C cg11890956 chr21:40555474 PSMG1 1.09 18.81 0.72 4.31e-54 Cognitive function; CRC cis rs6570726 0.791 rs1280276 chr6:145892350 A/C cg23711669 chr6:146136114 FBXO30 0.77 13.51 0.6 2.17e-33 Lobe attachment (rater-scored or self-reported); CRC cis rs6998277 0.830 rs17186961 chr8:103630028 G/A cg10187029 chr8:103597600 NA 0.9 13.11 0.59 7.2e-32 Migraine; CRC cis rs6121246 0.821 rs3181073 chr20:30307199 A/C cg13852791 chr20:30311386 BCL2L1 -0.63 -11.17 -0.52 8.85e-25 Mean corpuscular hemoglobin; CRC cis rs78456975 1.000 rs28742145 chr2:1562671 T/C cg01028140 chr2:1542097 TPO -0.58 -6.07 -0.32 3.5e-9 Placebo response in major depressive disorder (% change in symptom score); CRC cis rs4969178 0.931 rs6501208 chr17:76395038 A/T cg20026190 chr17:76395443 PGS1 0.4 6.22 0.32 1.53e-9 HDL cholesterol levels; CRC cis rs7274811 0.901 rs1074683 chr20:32304653 C/G cg03904042 chr20:32255491 NECAB3;C20orf134 -0.53 -6.9 -0.36 2.67e-11 Height; CRC cis rs7811142 1.000 rs2406255 chr7:100053690 T/C cg00814883 chr7:100076585 TSC22D4 -0.79 -9.9 -0.48 2.1e-20 Platelet count; CRC cis rs12826942 0.718 rs12827742 chr12:42542861 A/G cg11827402 chr12:42719852 PPHLN1;ZCRB1 0.57 6.46 0.34 3.69e-10 Coronary artery disease; CRC cis rs3858526 0.676 rs10838752 chr11:5887243 A/G cg13902645 chr11:5959945 NA -0.57 -7.63 -0.39 2.49e-13 DNA methylation (variation); CRC cis rs877282 0.583 rs10904562 chr10:819058 T/C cg17470449 chr10:769945 NA 0.57 7.87 0.4 5.29e-14 Uric acid levels; CRC cis rs9902453 0.967 rs4325622 chr17:28526475 T/C cg26525008 chr17:28256777 EFCAB5;SSH2 0.56 8.33 0.42 2.14e-15 Coffee consumption (cups per day); CRC cis rs3849570 1.000 rs13088000 chr3:81839404 T/C cg07356753 chr3:81810745 GBE1 -0.72 -10.97 -0.52 4.7e-24 Waist circumference;Body mass index; CRC cis rs367943 0.901 rs348951 chr5:112822017 G/C cg12552261 chr5:112820674 MCC -0.49 -7.58 -0.39 3.45e-13 Type 2 diabetes; CRC cis rs1799949 1.000 rs8176296 chr17:41203591 T/C cg19454999 chr17:41278357 BRCA1;NBR2 0.54 8.53 0.43 5.37e-16 Menopause (age at onset); CRC cis rs514406 0.861 rs1412706 chr1:53237721 G/A cg24675658 chr1:53192096 ZYG11B 0.56 8.13 0.41 8.59e-15 Monocyte count; CRC cis rs748404 0.631 rs12905772 chr15:43648444 G/A cg02155558 chr15:43621948 ADAL;LCMT2 0.54 7.89 0.4 4.53e-14 Lung cancer; CRC cis rs9837602 0.507 rs793455 chr3:99526135 C/A cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G -0.48 -6.39 -0.33 5.51e-10 Breast cancer; CRC cis rs3741404 0.895 rs2429455 chr11:63995302 C/G cg06243084 chr11:63990629 FERMT3 -0.39 -6.16 -0.32 2.1e-9 Platelet count; CRC trans rs1455244 0.700 rs7229302 chr18:11508904 G/T cg25050353 chr11:119599427 PVRL1 0.38 6.02 0.31 4.58e-9 Schizophrenia; CRC cis rs243505 0.762 rs734002 chr7:148505788 A/G cg09806900 chr7:148480153 CUL1 0.41 6.2 0.32 1.71e-9 Inflammatory bowel disease;Crohn's disease; CRC cis rs4819052 0.851 rs2838857 chr21:46681000 A/G cg11663144 chr21:46675770 NA -0.77 -12.68 -0.57 2.93e-30 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs16924133 0.793 rs11032153 chr11:33153026 G/A cg05567920 chr11:33183001 CSTF3 -0.78 -5.92 -0.31 7.95e-9 Anger; CRC cis rs1865760 0.566 rs10807006 chr6:26048752 C/A cg18357526 chr6:26021779 HIST1H4A 0.41 5.8 0.3 1.54e-8 Height; CRC cis rs12142240 0.698 rs17361791 chr1:46812519 A/G cg00530320 chr1:46809349 NSUN4 0.58 7.8 0.4 8.18e-14 Menopause (age at onset); CRC cis rs1862618 0.802 rs2591949 chr5:56132627 T/C cg03609598 chr5:56110824 MAP3K1 -0.81 -10.01 -0.48 8.99e-21 Initial pursuit acceleration; CRC cis rs6964587 0.869 rs10242792 chr7:91492103 A/C cg17063962 chr7:91808500 NA 0.71 11.81 0.55 4.64e-27 Breast cancer; CRC cis rs9341808 1.000 rs9341808 chr6:80953257 C/A cg08355045 chr6:80787529 NA 0.38 6.48 0.34 3.3e-10 Sitting height ratio; CRC cis rs898097 0.841 rs9896263 chr17:80902741 A/G cg19046167 chr17:80928561 B3GNTL1 0.43 6.71 0.35 8.61e-11 Breast cancer; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg23602684 chr14:24584099 DCAF11 0.44 6.0 0.31 5.24e-9 Anxiety disorder; CRC cis rs911555 0.755 rs10144051 chr14:103885931 A/C cg24130564 chr14:104152367 KLC1 -0.43 -5.81 -0.31 1.45e-8 Intelligence (multi-trait analysis); CRC cis rs4731207 0.698 rs12537161 chr7:124538590 A/G cg23710748 chr7:124431027 NA -0.38 -6.05 -0.32 3.86e-9 Cutaneous malignant melanoma; CRC cis rs7786808 0.741 rs11769149 chr7:158227127 A/G cg17401720 chr7:158221031 PTPRN2 -0.49 -8.08 -0.41 1.24e-14 Obesity-related traits; CRC cis rs3820928 0.967 rs4675118 chr2:227773157 C/A cg11843606 chr2:227700838 RHBDD1 -0.4 -5.88 -0.31 1.03e-8 Pulmonary function; CRC cis rs6968419 0.674 rs11767092 chr7:115907865 C/T cg02561103 chr7:115862891 TES -0.42 -6.2 -0.32 1.66e-9 Intraocular pressure; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg23435730 chr3:127770634 SEC61A1 0.41 6.29 0.33 1.03e-9 Intelligence (multi-trait analysis); CRC cis rs9905704 0.918 rs304293 chr17:56823298 T/G cg12560992 chr17:57184187 TRIM37 0.53 7.22 0.37 3.53e-12 Testicular germ cell tumor; CRC cis rs17162190 0.698 rs6690458 chr1:26789787 T/C cg17456097 chr1:26900765 RPS6KA1 0.47 6.62 0.34 1.5e-10 Mean corpuscular volume; CRC trans rs11039798 0.512 rs28453037 chr11:49006929 C/A cg15704280 chr7:45808275 SEPT13 0.61 6.24 0.33 1.32e-9 Axial length; CRC cis rs35146811 0.625 rs2906645 chr7:99817859 A/G cg13334819 chr7:99746414 C7orf59 0.56 7.27 0.37 2.61e-12 Coronary artery disease; CRC trans rs17685 0.736 rs4732594 chr7:75753273 T/C cg19862616 chr7:65841803 NCRNA00174 0.99 18.11 0.71 2.51e-51 Coffee consumption;Coffee consumption (cups per day); CRC trans rs853679 0.513 rs13437444 chr6:28070998 C/T cg06606381 chr12:133084897 FBRSL1 -0.67 -6.46 -0.34 3.87e-10 Depression; CRC cis rs7662987 0.517 rs2602845 chr4:100023944 T/C cg13256891 chr4:100009986 ADH5 0.63 8.56 0.43 4.54e-16 Smoking initiation; CRC cis rs1572438 0.811 rs6916731 chr6:880428 G/C cg21062780 chr6:887772 NA 0.41 6.71 0.35 8.31e-11 Aging; CRC cis rs17253792 0.822 rs10148983 chr14:56051879 A/G cg01858014 chr14:56050164 KTN1 -0.92 -8.23 -0.41 4.33e-15 Putamen volume; CRC cis rs8044995 0.563 rs61602448 chr16:68377520 C/T cg09835421 chr16:68378352 PRMT7 -0.77 -7.94 -0.4 3.2e-14 Schizophrenia; CRC cis rs992157 0.796 rs55680399 chr2:219160621 T/C cg00012203 chr2:219082015 ARPC2 0.45 6.9 0.36 2.6e-11 Colorectal cancer; CRC cis rs17092148 0.887 rs932542 chr20:33171368 G/C cg08999081 chr20:33150536 PIGU 0.5 6.17 0.32 2.02e-9 Neuroticism; CRC cis rs17767392 0.958 rs34469007 chr14:71916923 A/G cg13720639 chr14:72061746 SIPA1L1 -0.56 -7.11 -0.36 7.27e-12 Mitral valve prolapse; CRC cis rs6701037 1.000 rs6701037 chr1:175120079 G/T cg00321850 chr1:175162397 KIAA0040 0.36 5.91 0.31 8.56e-9 Alcohol dependence; CRC cis rs10504229 0.728 rs17804774 chr8:58155950 G/T cg05313129 chr8:58192883 C8orf71 -0.48 -6.25 -0.33 1.29e-9 Developmental language disorder (linguistic errors); CRC cis rs2075165 0.901 rs7542798 chr1:156224304 A/G cg20302342 chr1:156215951 PAQR6 0.38 7.5 0.38 5.95e-13 Tonsillectomy; CRC cis rs13031619 0.660 rs35668314 chr2:3702673 C/T cg10645314 chr2:3704589 ALLC -0.88 -10.39 -0.5 4.67e-22 Response to inhaled corticosteroid treatment in asthma (change in FEV1); CRC cis rs2839186 0.709 rs2156117 chr21:47669300 C/A cg11766577 chr21:47581405 C21orf56 -0.45 -7.21 -0.37 3.86e-12 Testicular germ cell tumor; CRC cis rs9611565 0.802 rs4822028 chr22:41789408 A/G cg03806693 chr22:41940476 POLR3H -0.96 -12.22 -0.56 1.4e-28 Vitiligo; CRC cis rs853679 0.542 rs2295594 chr6:28053097 G/A cg25164649 chr6:28176230 NA 0.73 9.18 0.45 4.85e-18 Depression; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg09713000 chr3:186524298 RFC4 0.45 6.03 0.32 4.37e-9 Anxiety disorder; CRC trans rs561341 0.882 rs2521594 chr17:30302087 C/T cg27661571 chr11:113659931 NA -0.96 -11.24 -0.53 5.15e-25 Hip circumference adjusted for BMI; CRC cis rs4665809 0.590 rs62128457 chr2:26467347 C/A cg08067268 chr2:26466485 HADHB;HADHA 0.65 8.34 0.42 2e-15 Gut microbiome composition (summer); CRC cis rs2243480 1.000 rs7804223 chr7:65664559 T/G cg18252515 chr7:66147081 NA 1.28 14.73 0.63 4.44e-38 Diabetic kidney disease; CRC cis rs6951245 1.000 rs78896566 chr7:1080182 C/G cg08132940 chr7:1081526 C7orf50 -0.54 -5.64 -0.3 3.65e-8 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC trans rs6956675 1.000 rs7801458 chr7:62597651 A/G cg01314568 chr7:57830625 NA -0.68 -9.37 -0.46 1.15e-18 Obesity-related traits; CRC cis rs4422723 0.724 rs10279261 chr7:133589846 C/T cg03336402 chr7:133662267 EXOC4 -0.42 -6.11 -0.32 2.8e-9 Intelligence (multi-trait analysis); CRC cis rs1865760 0.929 rs1436307 chr6:25939723 C/T cg16482183 chr6:26056742 HIST1H1C 0.53 7.44 0.38 8.68e-13 Height; CRC cis rs9547692 1.000 rs604279 chr13:37471254 G/C cg01493522 chr13:37497338 NA -0.43 -6.25 -0.33 1.31e-9 Coronary artery disease; CRC cis rs9291683 0.507 rs6827754 chr4:10018153 A/C cg00071950 chr4:10020882 SLC2A9 -0.58 -10.29 -0.49 9.95e-22 Bone mineral density; CRC trans rs208520 0.770 rs2153941 chr6:66885521 A/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.91 -12.38 -0.56 3.59e-29 Exhaled nitric oxide output; CRC cis rs4604732 0.631 rs4436425 chr1:247632323 T/C cg02104434 chr1:247694406 LOC148824;OR2C3 0.53 7.87 0.4 5.21e-14 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CRC cis rs847649 0.731 rs2298854 chr7:102729631 T/G cg18108683 chr7:102477205 FBXL13 0.53 8.12 0.41 9.44e-15 Morning vs. evening chronotype; CRC cis rs7662987 0.517 rs2034696 chr4:100024322 C/G cg13256891 chr4:100009986 ADH5 0.63 8.56 0.43 4.54e-16 Smoking initiation; CRC cis rs2180341 1.000 rs2326567 chr6:127606160 G/A cg27446573 chr6:127587934 RNF146 0.99 14.76 0.63 3.48e-38 Breast cancer; CRC cis rs7312933 0.558 rs11181483 chr12:42798384 G/C cg11827402 chr12:42719852 PPHLN1;ZCRB1 0.68 9.56 0.47 2.84e-19 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CRC cis rs9368481 0.761 rs6918835 chr6:27017827 T/G cg18278486 chr6:26987575 LOC100270746;C6orf41 -0.42 -6.46 -0.34 3.8e-10 Autism spectrum disorder or schizophrenia; CRC cis rs3845702 0.935 rs3845695 chr2:180796989 A/G cg23417306 chr2:180868811 CWC22 -0.42 -5.73 -0.3 2.22e-8 Schizophrenia; CRC cis rs1878931 0.582 rs40633 chr16:3425325 A/G cg02880119 chr16:3481970 NA 0.41 5.86 0.31 1.1e-8 Body mass index (adult); CRC cis rs6570726 0.935 rs371744 chr6:145841024 C/T cg13319975 chr6:146136371 FBXO30 -0.38 -5.8 -0.3 1.53e-8 Lobe attachment (rater-scored or self-reported); CRC cis rs1707322 1.000 rs10158032 chr1:46332701 T/C cg03146154 chr1:46216737 IPP 0.49 6.86 0.35 3.53e-11 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs2635047 0.783 rs9952447 chr18:44784700 C/T cg19077165 chr18:44547161 KATNAL2 -0.41 -6.26 -0.33 1.17e-9 Educational attainment; CRC cis rs561341 1.000 rs8064843 chr17:30245744 A/G cg00745463 chr17:30367425 LRRC37B -0.55 -6.91 -0.36 2.54e-11 Hip circumference adjusted for BMI; CRC cis rs7666738 0.830 rs10010223 chr4:99021758 G/A cg17366294 chr4:99064904 C4orf37 0.43 7.29 0.37 2.28e-12 Colonoscopy-negative controls vs population controls; CRC cis rs72945132 0.882 rs61260732 chr11:70162145 G/A cg00319359 chr11:70116639 PPFIA1 0.67 7.46 0.38 7.95e-13 Coronary artery disease; CRC cis rs10504229 1.000 rs76023408 chr8:58193345 A/G cg02725872 chr8:58115012 NA -0.38 -6.41 -0.33 5.11e-10 Developmental language disorder (linguistic errors); CRC cis rs9926296 0.581 rs2108838 chr16:89904426 A/G cg04287289 chr16:89883240 FANCA 0.61 9.57 0.47 2.63e-19 Vitiligo; CRC cis rs2230307 0.536 rs496798 chr1:100507990 G/A cg24955406 chr1:100503596 HIAT1 0.61 7.32 0.37 1.88e-12 Carotid intima media thickness; CRC cis rs7635838 0.892 rs6792718 chr3:11434380 A/G cg00170343 chr3:11313890 ATG7 0.41 6.32 0.33 8.44e-10 HDL cholesterol; CRC cis rs561341 0.739 rs7213369 chr17:30211878 G/A cg00745463 chr17:30367425 LRRC37B 0.58 7.55 0.38 4.37e-13 Hip circumference adjusted for BMI; CRC cis rs7726839 0.574 rs72705014 chr5:619815 C/G cg14541582 chr5:601475 NA -0.36 -7.29 -0.37 2.3e-12 Obesity-related traits; CRC cis rs2576037 0.796 rs2571031 chr18:44577063 T/C cg19077165 chr18:44547161 KATNAL2 0.43 6.71 0.35 8.7e-11 Personality dimensions; CRC cis rs1577917 0.958 rs1335442 chr6:86466692 C/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.61 -7.67 -0.39 1.95e-13 Response to antipsychotic treatment; CRC cis rs7772486 0.686 rs10872579 chr6:145966012 C/G cg23711669 chr6:146136114 FBXO30 0.65 10.7 0.51 4.03e-23 Lobe attachment (rater-scored or self-reported); CRC cis rs524281 0.861 rs10791854 chr11:65963543 A/T cg16950941 chr11:66035639 RAB1B -0.61 -7.54 -0.38 4.59e-13 Electroencephalogram traits; CRC cis rs12824058 0.831 rs55726136 chr12:130810312 G/A cg24838063 chr12:130822603 PIWIL1 0.58 9.77 0.47 5.67e-20 Menopause (age at onset); CRC cis rs62244186 0.659 rs56234157 chr3:44516221 G/A cg10263370 chr3:44754102 ZNF502 -0.36 -5.92 -0.31 8.3e-9 Depressive symptoms; CRC cis rs7927771 1.000 rs4752797 chr11:47874364 C/T cg20307385 chr11:47447363 PSMC3 -0.49 -6.53 -0.34 2.53e-10 Subjective well-being; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg21012871 chr20:42939451 FITM2 0.43 6.24 0.33 1.33e-9 Intelligence (multi-trait analysis); CRC cis rs10504229 0.639 rs35527749 chr8:58128077 G/T cg08219700 chr8:58056026 NA 0.56 6.58 0.34 1.91e-10 Developmental language disorder (linguistic errors); CRC cis rs35110281 0.713 rs6518310 chr21:45098670 T/A cg01579765 chr21:45077557 HSF2BP -0.31 -5.9 -0.31 9.11e-9 Mean corpuscular volume; CRC cis rs4746091 0.760 rs56235440 chr10:73390724 G/A cg22763136 chr10:73395000 CDH23 0.43 5.93 0.31 7.51e-9 Selective IgA deficiency; CRC cis rs9325144 0.534 rs1843866 chr12:38703160 G/T cg26384229 chr12:38710491 ALG10B 0.54 8.16 0.41 7.21e-15 Morning vs. evening chronotype; CRC cis rs7677751 0.767 rs890205 chr4:55063373 C/A cg13615338 chr4:55094005 PDGFRA 0.41 5.86 0.31 1.11e-8 Corneal astigmatism; CRC cis rs10791097 0.592 rs7116068 chr11:130732739 A/C cg12179176 chr11:130786555 SNX19 -0.72 -11.66 -0.54 1.55e-26 Autism spectrum disorder or schizophrenia;Schizophrenia; CRC cis rs870825 0.655 rs35397385 chr4:185639095 C/T cg04058563 chr4:185651563 MLF1IP 0.73 9.54 0.47 3.37e-19 Blood protein levels; CRC cis rs769267 0.831 rs2872878 chr19:19480521 G/C cg02546618 chr19:19431379 KIAA0892;SF4 -0.44 -6.07 -0.32 3.51e-9 Tonsillectomy; CRC cis rs758324 0.773 rs40819 chr5:131305384 G/T cg25547332 chr5:131281432 NA -0.36 -5.76 -0.3 1.95e-8 Alzheimer's disease in APOE e4- carriers; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg03965198 chr11:125932701 CDON 0.45 5.96 0.31 6.37e-9 Anxiety disorder; CRC cis rs17253792 0.822 rs78922774 chr14:56115302 T/A cg24579896 chr14:56047964 C14orf33;KTN1 0.7 5.6 0.3 4.53e-8 Putamen volume; CRC cis rs9381040 0.610 rs9357345 chr6:41025118 G/C cg09580153 chr6:41068724 NFYA;LOC221442 -0.42 -6.12 -0.32 2.71e-9 Alzheimer's disease (late onset); CRC cis rs4363385 0.747 rs6671414 chr1:152974119 C/T cg25856811 chr1:152973957 SPRR3 -0.25 -6.76 -0.35 6.27e-11 Inflammatory skin disease; CRC cis rs600806 0.850 rs6537757 chr1:109936682 G/A cg23032129 chr1:109941072 SORT1 -0.27 -5.84 -0.31 1.24e-8 Intelligence (multi-trait analysis); CRC cis rs2836974 0.545 rs3167757 chr21:40714478 C/T cg11890956 chr21:40555474 PSMG1 0.69 10.37 0.5 5.39e-22 Cognitive function; CRC cis rs77633900 0.614 rs2459363 chr15:76874952 T/C cg21673338 chr15:77095150 SCAPER -0.71 -7.11 -0.37 7.06e-12 Non-glioblastoma glioma;Glioma; CRC cis rs2303759 0.709 rs7256363 chr19:49827804 C/T cg22133161 chr19:49891603 CCDC155 0.51 6.65 0.34 1.21e-10 Multiple sclerosis; CRC cis rs6502050 0.835 rs8077926 chr17:80117315 C/A cg11859384 chr17:80120422 CCDC57 -0.37 -5.98 -0.31 5.86e-9 Life satisfaction; CRC cis rs7493 0.950 rs17879277 chr7:95030632 A/C cg17330251 chr7:94953956 PON1 -0.58 -7.44 -0.38 8.81e-13 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs9640161 0.742 rs2159235 chr7:150017228 T/C cg13722127 chr7:150037890 RARRES2 0.48 7.45 0.38 8.04e-13 Blood protein levels;Circulating chemerin levels; CRC cis rs7020830 0.894 rs12337316 chr9:37148105 G/A cg14294708 chr9:37120828 ZCCHC7 1.05 19.96 0.74 1.21e-58 Schizophrenia; CRC cis rs10751667 0.643 rs11246344 chr11:933783 A/C ch.11.42038R chr11:967971 AP2A2 0.6 10.26 0.49 1.35e-21 Alzheimer's disease (late onset); CRC cis rs68170813 0.641 rs61511581 chr7:106948091 T/A cg02696742 chr7:106810147 HBP1 -0.51 -5.86 -0.31 1.13e-8 Coronary artery disease; CRC cis rs9925964 0.744 rs12716979 chr16:31011821 T/G cg02466173 chr16:30829666 NA 0.41 5.85 0.31 1.19e-8 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs904251 0.600 rs4714068 chr6:37455642 A/C cg25019722 chr6:37503610 NA -0.35 -6.07 -0.32 3.48e-9 Cognitive performance; CRC trans rs1814175 0.791 rs7395713 chr11:49877887 A/G cg03929089 chr4:120376271 NA -0.97 -19.07 -0.72 3.93e-55 Height; CRC cis rs17401966 0.838 rs12738317 chr1:10419663 C/T cg19773385 chr1:10388646 KIF1B -0.66 -10.72 -0.51 3.52e-23 Hepatocellular carcinoma; CRC cis rs77216612 1.000 rs77216612 chr12:12877983 A/G cg04607235 chr12:12878440 APOLD1 -1.01 -13.78 -0.6 2.03e-34 Lymphocyte counts; CRC cis rs35146811 0.735 rs11767968 chr7:99790971 G/A cg00553149 chr7:99775558 STAG3;GPC2 0.24 5.9 0.31 8.81e-9 Coronary artery disease; CRC cis rs7811142 1.000 rs60478351 chr7:100089017 C/T cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.6 7.74 0.39 1.27e-13 Platelet count; CRC cis rs2228479 0.850 rs11641552 chr16:89838700 C/A cg19635926 chr16:89946313 TCF25 0.62 5.73 0.3 2.3e-8 Skin colour saturation; CRC cis rs12701220 0.744 rs35588238 chr7:1012006 G/A cg02733842 chr7:1102375 C7orf50 -0.55 -6.92 -0.36 2.38e-11 Bronchopulmonary dysplasia; CRC cis rs2742417 0.603 rs2064062 chr3:45761115 G/C cg04837898 chr3:45731254 SACM1L -0.49 -7.88 -0.4 4.7e-14 Response to anti-depressant treatment in major depressive disorder; CRC cis rs738322 1.000 rs738320 chr22:38568715 G/T cg17652424 chr22:38574118 PLA2G6 -0.22 -6.71 -0.35 8.32e-11 Cutaneous nevi; CRC cis rs7772486 0.623 rs735535 chr6:146036829 C/T cg13319975 chr6:146136371 FBXO30 0.44 6.64 0.34 1.3100000000000001e-10 Lobe attachment (rater-scored or self-reported); CRC cis rs79349575 0.783 rs4255820 chr17:46996583 T/A cg00947319 chr17:47005597 UBE2Z -0.34 -5.88 -0.31 1.02e-8 Type 2 diabetes; CRC cis rs4665809 0.590 rs1560865 chr2:26452197 C/A cg27170947 chr2:26402098 FAM59B -0.63 -8.51 -0.42 6.43e-16 Gut microbiome composition (summer); CRC cis rs10479542 0.784 rs6601050 chr5:178986261 C/G cg09060608 chr5:178986726 RUFY1 -0.53 -9.45 -0.46 6.68e-19 Lung cancer; CRC cis rs9534288 0.797 rs2404727 chr13:46581697 T/C cg15192986 chr13:46630673 CPB2 -0.67 -9.85 -0.48 3.16e-20 Blood protein levels; CRC cis rs801193 0.660 rs974239 chr7:66213491 G/A cg18876405 chr7:65276391 NA 0.51 8.36 0.42 1.82e-15 Aortic root size; CRC cis rs9287719 0.967 rs7355649 chr2:10748094 C/A cg00105475 chr2:10696890 NA 0.46 7.42 0.38 1.01e-12 Prostate cancer; CRC cis rs17227506 0.900 rs1105406 chr8:13447025 G/A cg03566418 chr8:13424080 C8orf48 0.35 6.35 0.33 7.31e-10 Nonsyndromic cleft lip with cleft palate; CRC cis rs910316 0.810 rs77939209 chr14:75670070 A/G cg11812906 chr14:75593930 NEK9 -0.54 -8.07 -0.41 1.38e-14 Height; CRC cis rs9311676 0.656 rs11130634 chr3:58379123 A/C cg06643156 chr3:58380774 PXK 0.41 6.33 0.33 7.82e-10 Systemic lupus erythematosus; CRC trans rs9858542 1.000 rs13316695 chr3:49684917 C/G cg21582582 chr3:182698605 DCUN1D1 -0.58 -7.1 -0.36 7.97e-12 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs6424115 0.708 rs11803575 chr1:24182348 A/T cg08896387 chr1:24191740 FUCA1 0.51 6.89 0.36 2.77e-11 Immature fraction of reticulocytes; CRC cis rs6860806 0.507 rs272892 chr5:131664349 C/T cg20512303 chr5:131592959 PDLIM4 0.39 6.75 0.35 6.7e-11 Breast cancer; CRC cis rs57920188 0.640 rs10915600 chr1:4082105 T/G cg10510935 chr1:4059661 NA 0.4 5.92 0.31 7.9e-9 Interleukin-17 levels; CRC trans rs1656966 1.000 rs1656966 chr3:186466252 C/T cg20783262 chr1:68152310 GADD45A 0.43 6.61 0.34 1.56e-10 Myopia (pathological); CRC cis rs4237845 0.611 rs4583019 chr12:58316745 T/C cg00677455 chr12:58241039 CTDSP2 0.43 6.23 0.32 1.45e-9 Intelligence (multi-trait analysis); CRC cis rs6964587 1.000 rs7811873 chr7:91751120 G/A cg17063962 chr7:91808500 NA 0.84 14.73 0.63 4.33e-38 Breast cancer; CRC cis rs2976388 1.000 rs2976396 chr8:143764001 A/G cg24046110 chr8:143859143 LYNX1 0.36 6.27 0.33 1.17e-9 Urinary tract infection frequency; CRC cis rs5758511 0.573 rs4501042 chr22:42245763 C/T cg00645731 chr22:42541494 CYP2D7P1 -0.37 -5.97 -0.31 6.13e-9 Birth weight; CRC cis rs62229266 0.835 rs998384 chr21:37445526 G/C cg08632701 chr21:37451849 NA -0.44 -6.77 -0.35 5.9e-11 Mitral valve prolapse; CRC cis rs9611565 0.649 rs202657 chr22:41844786 G/T cg06481639 chr22:41940642 POLR3H 0.53 6.01 0.31 5.01e-9 Vitiligo; CRC cis rs9291683 0.588 rs6844329 chr4:10018544 T/C cg11266682 chr4:10021025 SLC2A9 0.54 11.57 0.54 3.2e-26 Bone mineral density; CRC cis rs12216125 0.554 rs6942196 chr6:26072804 A/G cg16482183 chr6:26056742 HIST1H1C 0.52 7.63 0.39 2.51e-13 Iron status biomarkers; CRC cis rs9733 0.519 rs72704603 chr1:150707992 C/T cg18016565 chr1:150552671 MCL1 0.48 6.88 0.35 3.02e-11 Tonsillectomy; CRC cis rs10779751 0.960 rs12739368 chr1:11288247 T/C cg08854313 chr1:11322531 MTOR 0.65 9.24 0.45 3.05e-18 Body mass index; CRC cis rs5750830 0.621 rs5757665 chr22:39821641 A/G cg05872129 chr22:39784769 NA -0.57 -10.08 -0.49 5.26e-21 Intelligence (multi-trait analysis); CRC cis rs2302190 0.882 rs3744111 chr17:56607959 G/A cg12560992 chr17:57184187 TRIM37 0.5 5.87 0.31 1.05e-8 Vitamin D levels; CRC cis rs10944 0.598 rs1717570 chr5:78276474 C/T cg13121490 chr5:78280331 ARSB 0.43 6.16 0.32 2.18e-9 Blood and toenail selenium levels; CRC cis rs2274273 0.870 rs28716725 chr14:55816610 T/C cg23234261 chr14:55582407 NA -0.29 -5.8 -0.3 1.58e-8 Protein biomarker; CRC cis rs4727027 0.901 rs10952792 chr7:148760501 C/T cg23583168 chr7:148888333 NA -0.89 -15.31 -0.64 2.57e-40 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC trans rs9329221 0.527 rs4841352 chr8:10327590 A/C cg06636001 chr8:8085503 FLJ10661 0.46 6.79 0.35 5.35e-11 Neuroticism; CRC cis rs67311347 0.866 rs1454491 chr3:40352647 C/G cg09455208 chr3:40491958 NA 0.33 6.41 0.33 4.91e-10 Renal cell carcinoma; CRC cis rs6121246 0.909 rs6119729 chr20:30413163 A/G cg18721089 chr20:30220636 NA 0.36 5.66 0.3 3.27e-8 Mean corpuscular hemoglobin; CRC cis rs10504229 0.679 rs16920056 chr8:58106218 C/A cg02290350 chr8:58132656 NA -0.59 -8.02 -0.4 1.88e-14 Developmental language disorder (linguistic errors); CRC trans rs3960554 0.673 rs112680895 chr7:75623520 G/A cg19862616 chr7:65841803 NCRNA00174 0.71 8.19 0.41 5.78e-15 Eotaxin levels; CRC trans rs2303319 0.504 rs62188988 chr2:162531068 T/C cg27342122 chr8:133787442 PHF20L1 -0.7 -6.02 -0.31 4.64e-9 Cognitive function; CRC cis rs34375054 0.526 rs117431213 chr12:125675271 C/G cg02766259 chr12:125626809 AACS -0.45 -7.74 -0.39 1.27e-13 Post bronchodilator FEV1/FVC ratio; CRC cis rs9311474 0.508 rs7625743 chr3:52606366 C/G cg05573699 chr3:52720067 GNL3;PBRM1 -0.47 -6.96 -0.36 1.9e-11 Electroencephalogram traits; CRC cis rs2795502 0.873 rs3121282 chr10:43423626 T/A cg20628663 chr10:43360327 NA 0.58 9.05 0.45 1.32e-17 Blood protein levels; CRC cis rs9322817 0.691 rs4460239 chr6:105325562 C/T cg02098413 chr6:105308735 HACE1 0.43 8.45 0.42 9.74e-16 Thyroid stimulating hormone; CRC cis rs17331151 0.505 rs13086936 chr3:52659079 T/C cg07884673 chr3:53033167 SFMBT1 0.78 6.22 0.32 1.53e-9 Immune reponse to smallpox (secreted IL-2); CRC cis rs2204008 0.715 rs11514282 chr12:38169056 G/T cg26384229 chr12:38710491 ALG10B 0.71 9.42 0.46 8.02e-19 Bladder cancer; CRC cis rs7618915 0.547 rs3774365 chr3:52642487 T/C cg05573699 chr3:52720067 GNL3;PBRM1 -0.46 -6.64 -0.34 1.29e-10 Bipolar disorder; CRC cis rs7605827 0.930 rs2052438 chr2:15701951 G/A cg19274914 chr2:15703543 NA 0.37 5.62 0.3 4.13e-8 Educational attainment (years of education); CRC cis rs7208859 0.573 rs73267865 chr17:29064204 C/G cg01831904 chr17:28903510 LRRC37B2 -0.62 -6.39 -0.33 5.8e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs13108904 0.837 rs4591539 chr4:1279938 G/C cg19318889 chr4:1322082 MAEA 0.4 5.68 0.3 2.94e-8 Obesity-related traits; CRC trans rs7395662 0.500 rs1304199 chr11:48699032 A/G cg15704280 chr7:45808275 SEPT13 -0.52 -7.5 -0.38 6.06e-13 HDL cholesterol; CRC cis rs9916302 0.904 rs2338800 chr17:37498149 C/G cg07936489 chr17:37558343 FBXL20 0.82 12.67 0.57 3.21e-30 Glomerular filtration rate (creatinine); CRC trans rs2243480 1.000 rs11538349 chr7:65421871 C/T cg10756647 chr7:56101905 PSPH 0.73 8.12 0.41 9.55e-15 Diabetic kidney disease; CRC cis rs875971 0.830 rs427575 chr7:65519219 A/G cg00343986 chr7:65444356 GUSB 0.46 6.82 0.35 4.27e-11 Aortic root size; CRC cis rs4665809 0.590 rs13387855 chr2:26420708 T/G cg27170947 chr2:26402098 FAM59B -0.59 -7.62 -0.39 2.79e-13 Gut microbiome composition (summer); CRC cis rs955333 0.565 rs7770413 chr6:154904487 A/G cg20019720 chr6:154832845 CNKSR3 0.34 6.14 0.32 2.34e-9 Diabetic kidney disease; CRC cis rs7772486 0.875 rs6934467 chr6:146410529 G/T cg23711669 chr6:146136114 FBXO30 0.67 11.61 0.54 2.47e-26 Lobe attachment (rater-scored or self-reported); CRC cis rs1728785 0.818 rs11075684 chr16:68582365 C/T cg02972257 chr16:68554789 NA -0.59 -7.2 -0.37 4.04e-12 Ulcerative colitis; CRC cis rs10504229 0.679 rs11783444 chr8:58131267 A/G cg02290350 chr8:58132656 NA -0.58 -8.16 -0.41 7.29e-15 Developmental language disorder (linguistic errors); CRC cis rs908922 1.000 rs908922 chr1:152454591 C/T cg23254163 chr1:152506842 NA 0.37 6.35 0.33 6.96e-10 Hair morphology; CRC cis rs6951245 1.000 rs79443843 chr7:1075245 G/A cg24642844 chr7:1081250 C7orf50 -0.77 -9.25 -0.45 2.96e-18 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs72781680 0.821 rs72781644 chr2:24209348 T/C cg08917208 chr2:24149416 ATAD2B 0.57 6.8 0.35 4.96e-11 Lymphocyte counts; CRC cis rs4638749 0.677 rs6711297 chr2:108818357 A/C cg25838818 chr2:108905173 SULT1C2 -0.34 -5.79 -0.3 1.68e-8 Blood pressure; CRC cis rs7223966 1.000 rs9899788 chr17:61756384 G/A cg23903597 chr17:61704154 MAP3K3 -0.42 -5.81 -0.3 1.51e-8 Hip circumference adjusted for BMI;Body mass index; CRC cis rs9462846 0.853 rs7740879 chr6:42873379 C/T cg21280719 chr6:42927975 GNMT 0.32 6.39 0.33 5.58e-10 Blood protein levels; CRC trans rs11148252 0.846 rs4886077 chr13:52998697 G/T cg18335740 chr13:41363409 SLC25A15 0.54 8.26 0.41 3.51e-15 Lewy body disease; CRC cis rs12760731 0.720 rs71628282 chr1:178449993 C/G cg00404053 chr1:178313656 RASAL2 1.16 11.88 0.55 2.6e-27 Obesity-related traits; CRC cis rs68170813 0.641 rs12532953 chr7:106865920 C/T cg02696742 chr7:106810147 HBP1 -0.6 -6.44 -0.33 4.33e-10 Coronary artery disease; CRC cis rs9322193 0.962 rs6903998 chr6:150152493 T/C cg05861140 chr6:150128134 PCMT1 -0.42 -6.79 -0.35 5.4e-11 Lung cancer; CRC cis rs798554 1.000 rs798559 chr7:2758341 T/C cg19346786 chr7:2764209 NA -0.41 -7.25 -0.37 2.96e-12 Height; CRC cis rs4731207 0.698 rs10233589 chr7:124468599 G/A cg23710748 chr7:124431027 NA 0.37 6.05 0.32 3.86e-9 Cutaneous malignant melanoma; CRC trans rs1728785 1.000 rs7195979 chr16:68586801 G/A cg04657470 chr2:198365150 HSPE1;HSPD1 0.77 9.04 0.45 1.42e-17 Ulcerative colitis; CRC cis rs2180341 0.960 rs6913424 chr6:127707010 A/C cg27446573 chr6:127587934 RNF146 0.98 13.77 0.6 2.19e-34 Breast cancer; CRC cis rs12824058 0.831 rs4759452 chr12:130812799 G/A cg24838063 chr12:130822603 PIWIL1 0.58 9.76 0.47 6.18e-20 Menopause (age at onset); CRC cis rs561341 1.000 rs546748 chr17:30324293 A/C cg12193833 chr17:30244370 NA -0.57 -8.0 -0.4 2.11e-14 Hip circumference adjusted for BMI; CRC cis rs9368481 0.743 rs9368480 chr6:26955750 A/C cg18867708 chr6:26865862 GUSBL1 0.45 6.24 0.33 1.34e-9 Autism spectrum disorder or schizophrenia; CRC cis rs8072100 0.967 rs8074149 chr17:45583375 A/C cg08085267 chr17:45401833 C17orf57 0.63 10.37 0.5 5.47e-22 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs6502050 0.764 rs7215277 chr17:80159283 C/A cg13198984 chr17:80129470 CCDC57 0.45 8.01 0.4 1.99e-14 Life satisfaction; CRC cis rs1506636 0.646 rs805776 chr7:123212561 T/C cg03229431 chr7:123269106 ASB15 -0.59 -8.34 -0.42 2.05e-15 Plateletcrit;Platelet count; CRC cis rs1580019 0.587 rs6972365 chr7:32548931 T/A cg14728415 chr7:32535168 LSM5;AVL9 0.45 6.48 0.34 3.28e-10 Cognitive ability; CRC cis rs2976388 0.566 rs6998746 chr8:143802456 A/C cg22687807 chr8:143858763 LYNX1 0.47 7.62 0.39 2.72e-13 Urinary tract infection frequency; CRC cis rs60871478 0.578 rs62432900 chr7:826794 G/C cg13798912 chr7:905769 UNC84A 0.51 5.81 0.31 1.45e-8 Cerebrospinal P-tau181p levels; CRC trans rs7937682 0.921 rs11213945 chr11:111461003 A/G cg18187862 chr3:45730750 SACM1L -0.58 -7.51 -0.38 5.78e-13 Primary sclerosing cholangitis; CRC cis rs6502050 0.835 rs8081783 chr17:80117388 G/A cg22110888 chr17:80059540 CCDC57 0.4 6.48 0.34 3.37e-10 Life satisfaction; CRC cis rs1008375 1.000 rs10027755 chr4:17615954 G/C cg04450456 chr4:17643702 FAM184B 0.37 6.11 0.32 2.84e-9 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs4072980 0.545 rs7528185 chr1:38452059 C/T cg12658694 chr1:38397304 INPP5B -0.53 -7.28 -0.37 2.47e-12 Coronary artery disease; CRC cis rs7301826 0.651 rs10744483 chr12:131298206 C/A cg11011512 chr12:131303247 STX2 0.37 5.62 0.3 4.1e-8 Plasma plasminogen activator levels; CRC cis rs7904368 0.806 rs3858182 chr10:16855094 C/T cg14835575 chr10:16859367 RSU1 0.49 6.49 0.34 3.08e-10 Ratio of the peak velocity of the mitral E-Wave divided by the peak velocity of the mitral A-wave.; CRC cis rs644799 0.930 rs3802764 chr11:95514599 T/A cg25478527 chr11:95522999 CEP57;FAM76B 0.53 7.88 0.4 4.93e-14 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC trans rs561341 0.709 rs11542477 chr17:30185892 A/G cg20587970 chr11:113659929 NA 1.05 12.29 0.56 8.25e-29 Hip circumference adjusted for BMI; CRC cis rs4925325 0.956 rs1776263 chr20:60515820 A/G cg13770153 chr20:60521292 NA -0.97 -16.9 -0.68 1.42e-46 Obesity-related traits; CRC cis rs7086627 0.515 rs4933390 chr10:82213081 A/C cg00277334 chr10:82204260 NA -0.82 -15.78 -0.66 3.61e-42 Post bronchodilator FEV1; CRC cis rs3768617 0.510 rs4651145 chr1:183098900 T/C ch.1.3577855R chr1:183094577 LAMC1 0.89 15.86 0.66 1.84e-42 Fuchs's corneal dystrophy; CRC cis rs7666738 0.830 rs9995370 chr4:98732145 T/G cg17366294 chr4:99064904 C4orf37 0.42 6.91 0.36 2.59e-11 Colonoscopy-negative controls vs population controls; CRC cis rs7107174 1.000 rs72931690 chr11:78073192 G/A cg02023728 chr11:77925099 USP35 0.48 7.29 0.37 2.35e-12 Testicular germ cell tumor; CRC cis rs7208859 0.623 rs3752019 chr17:29151705 C/T cg13385521 chr17:29058706 SUZ12P 0.64 7.26 0.37 2.79e-12 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs11628318 0.802 rs2277471 chr14:103024387 A/C cg23461800 chr14:103021989 NA 0.62 8.23 0.41 4.56e-15 Platelet count; CRC cis rs11764590 0.715 rs11760737 chr7:2104055 T/C cg02421172 chr7:1938701 MAD1L1 0.44 5.84 0.31 1.29e-8 Neuroticism; CRC cis rs4654899 0.931 rs10799679 chr1:21341776 A/G cg02927042 chr1:21476669 EIF4G3 -0.45 -7.39 -0.38 1.26e-12 Superior frontal gyrus grey matter volume; CRC cis rs17065868 0.764 rs56773929 chr13:45038130 G/A cg10246903 chr13:45222710 NA 0.54 5.69 0.3 2.79e-8 Antineutrophil cytoplasmic antibody-associated vasculitis; CRC cis rs4713118 0.955 rs9468203 chr6:27688667 A/G cg12172441 chr6:28176163 NA 0.48 6.17 0.32 1.96e-9 Parkinson's disease; CRC cis rs10504229 1.000 rs76023408 chr8:58193345 A/G cg24829409 chr8:58192753 C8orf71 -0.68 -11.28 -0.53 3.61e-25 Developmental language disorder (linguistic errors); CRC cis rs921968 0.607 rs2465100 chr2:219551044 A/T cg02176678 chr2:219576539 TTLL4 -0.46 -7.28 -0.37 2.48e-12 Mean corpuscular hemoglobin concentration; CRC cis rs10791323 0.536 rs4937842 chr11:133734542 C/G cg00579200 chr11:133705235 NA 0.39 5.79 0.3 1.67e-8 Childhood ear infection; CRC cis rs514406 0.861 rs2448792 chr1:53268313 T/C cg25767906 chr1:53392781 SCP2 0.47 7.49 0.38 6.24e-13 Monocyte count; CRC cis rs2019137 0.868 rs3748916 chr2:113984033 C/T cg11763394 chr2:113992921 PAX8;LOC440839;LOC654433 -0.5 -7.22 -0.37 3.64e-12 Lymphocyte counts; CRC cis rs6570726 0.526 rs7755237 chr6:145731852 T/C cg23711669 chr6:146136114 FBXO30 -0.51 -8.39 -0.42 1.41e-15 Lobe attachment (rater-scored or self-reported); CRC cis rs929354 0.772 rs3802118 chr7:156986814 T/C cg17757837 chr7:157058334 UBE3C 0.74 12.6 0.57 5.83e-30 Body mass index; CRC cis rs11148252 0.538 rs9526842 chr13:52727723 T/G cg12458913 chr13:53173898 NA 0.48 7.11 0.36 7.38e-12 Lewy body disease; CRC cis rs6840360 1.000 rs6823421 chr4:152604719 T/C cg09659197 chr4:152720779 NA 0.49 10.43 0.5 3.46e-22 Intelligence (multi-trait analysis); CRC trans rs877282 0.583 rs11253425 chr10:815173 G/A cg22713356 chr15:30763199 NA 0.89 10.1 0.49 4.41e-21 Uric acid levels; CRC cis rs60154123 0.505 rs115881613 chr1:210040369 C/T cg22029157 chr1:209979665 IRF6 0.61 6.76 0.35 6.47e-11 Coronary artery disease; CRC cis rs7829975 0.902 rs777707 chr8:8584344 A/G cg06636001 chr8:8085503 FLJ10661 0.57 9.05 0.45 1.26e-17 Mood instability; CRC cis rs6502050 0.835 rs35555954 chr17:80122438 T/C cg25804541 chr17:80189381 SLC16A3 -0.31 -5.98 -0.31 5.92e-9 Life satisfaction; CRC cis rs10744422 0.800 rs2343110 chr12:123343571 T/G cg25930673 chr12:123319894 HIP1R -0.6 -6.31 -0.33 9.25e-10 Schizophrenia; CRC cis rs9322193 0.923 rs10782315 chr6:150064229 T/C cg07701084 chr6:150067640 NUP43 0.61 9.12 0.45 7.81e-18 Lung cancer; CRC cis rs2737618 0.651 rs2248967 chr1:200084893 A/G cg21825944 chr1:200113062 NR5A2 0.5 7.5 0.38 5.95e-13 Uric acid levels; CRC cis rs10504229 0.636 rs117439064 chr8:58055279 A/G cg02290350 chr8:58132656 NA -0.6 -6.94 -0.36 2.16e-11 Developmental language disorder (linguistic errors); CRC trans rs11098499 0.779 rs7674500 chr4:120303593 C/T cg25214090 chr10:38739885 LOC399744 0.62 9.74 0.47 7.35e-20 Corneal astigmatism; CRC cis rs2242116 0.796 rs7645278 chr3:46974100 A/C cg27129171 chr3:47204927 SETD2 0.6 8.59 0.43 3.49e-16 Birth weight; CRC cis rs7666738 0.830 rs7657179 chr4:98948569 G/A cg17366294 chr4:99064904 C4orf37 0.43 7.34 0.38 1.69e-12 Colonoscopy-negative controls vs population controls; CRC cis rs2032447 0.714 rs199739 chr6:25960509 A/C cg04800585 chr6:26043546 HIST1H2BB 0.53 7.77 0.39 1.04e-13 Intelligence (multi-trait analysis); CRC cis rs2949837 0.581 rs2960434 chr7:45972977 A/G cg04796162 chr7:45961102 IGFBP3 0.38 6.62 0.34 1.49e-10 Sitting height ratio; CRC trans rs8123881 0.733 rs7268466 chr20:15810676 C/T cg14727880 chr9:19049247 RRAGA 0.56 6.19 0.32 1.78e-9 Body mass index; CRC trans rs2228479 0.850 rs17233448 chr16:89816424 G/T cg21302420 chr1:112162376 RAP1A 0.72 6.01 0.31 5.05e-9 Skin colour saturation; CRC cis rs1534166 0.647 rs7355929 chr3:133514190 C/T cg08048268 chr3:133502702 NA 0.41 7.17 0.37 4.92e-12 Alcohol consumption (transferrin glycosylation); CRC cis rs9914988 0.832 rs9903248 chr17:27127439 G/T cg07195577 chr17:27052828 TLCD1 0.42 6.02 0.32 4.64e-9 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC trans rs10504229 1.000 rs17805549 chr8:58179653 T/C cg04077850 chr5:125800366 GRAMD3 0.37 6.27 0.33 1.15e-9 Developmental language disorder (linguistic errors); CRC cis rs3736485 0.966 rs7173880 chr15:51785433 C/A cg08986416 chr15:51914746 DMXL2 -0.44 -6.46 -0.34 3.66e-10 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs2120019 0.938 rs8036573 chr15:75308690 C/T cg11632617 chr15:75315747 PPCDC -0.53 -7.11 -0.37 7.14e-12 Blood trace element (Zn levels); CRC cis rs11608355 0.508 rs11066411 chr12:109804194 A/G cg19025524 chr12:109796872 NA -0.55 -8.06 -0.41 1.44e-14 Neuroticism; CRC cis rs10450586 0.863 rs10767631 chr11:27315853 C/G cg10370305 chr11:27303972 NA 0.35 5.69 0.3 2.76e-8 Total body bone mineral density; CRC cis rs9905704 0.647 rs11659035 chr17:56966052 C/T cg12560992 chr17:57184187 TRIM37 0.61 9.19 0.45 4.4e-18 Testicular germ cell tumor; CRC cis rs4132509 0.744 rs12031994 chr1:243917309 T/C cg21452805 chr1:244014465 NA 0.55 5.98 0.31 5.82e-9 RR interval (heart rate); CRC cis rs7618915 0.547 rs11709448 chr3:52647449 T/C cg11645453 chr3:52864694 ITIH4 0.36 6.27 0.33 1.14e-9 Bipolar disorder; CRC cis rs6460942 0.915 rs62448619 chr7:12457743 C/T cg06484146 chr7:12443880 VWDE -0.78 -8.1 -0.41 1.11e-14 Coronary artery disease; CRC cis rs4144743 1.000 rs72823473 chr17:45321775 A/T cg18085866 chr17:45331354 ITGB3 -0.61 -8.41 -0.42 1.28e-15 Body mass index; CRC cis rs172166 0.694 rs203892 chr6:28067196 T/C cg23161317 chr6:28129485 ZNF389 0.46 6.46 0.34 3.68e-10 Cardiac Troponin-T levels; CRC cis rs1003719 0.715 rs2835613 chr21:38496883 A/G cg10648535 chr21:38446584 PIGP;TTC3 -0.5 -6.92 -0.36 2.43e-11 Eye color traits; CRC cis rs765787 0.530 rs12903149 chr15:45539076 G/A cg24006582 chr15:45444508 DUOX1 0.58 8.31 0.42 2.56e-15 Uric acid levels; CRC cis rs11190604 1.000 rs2495759 chr10:102320363 C/T cg16342193 chr10:102329863 NA -0.39 -6.08 -0.32 3.35e-9 Palmitoleic acid (16:1n-7) levels; CRC cis rs919433 0.854 rs13013049 chr2:198208664 C/T cg10820045 chr2:198174542 NA -0.49 -7.76 -0.39 1.05e-13 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC cis rs727505 1.000 rs10230610 chr7:124425398 A/C cg23710748 chr7:124431027 NA -0.82 -14.38 -0.62 1.04e-36 Lewy body disease; CRC cis rs10991814 0.925 rs10991809 chr9:93946555 G/A cg14446406 chr9:93919335 NA 0.46 6.16 0.32 2.08e-9 Neutrophil percentage of granulocytes; CRC cis rs6840360 1.000 rs12331037 chr4:152663971 G/A cg09659197 chr4:152720779 NA 0.53 11.71 0.54 1.06e-26 Intelligence (multi-trait analysis); CRC cis rs896854 0.654 rs28591375 chr8:95973637 C/G cg13393036 chr8:95962371 TP53INP1 -0.54 -9.27 -0.46 2.49e-18 Type 2 diabetes; CRC cis rs6500602 0.727 rs12443748 chr16:4541831 C/T cg14951292 chr16:4525986 HMOX2;NMRAL1 0.6 9.37 0.46 1.16e-18 Schizophrenia; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg11464238 chr7:140179466 MKRN1 0.39 6.43 0.33 4.37e-10 Liver disease severity in Alagille syndrome; CRC cis rs453301 0.686 rs6601280 chr8:8909236 A/T cg06636001 chr8:8085503 FLJ10661 0.44 6.64 0.34 1.28e-10 Joint mobility (Beighton score); CRC trans rs944990 0.595 rs10123378 chr9:96375217 C/T cg19334895 chr19:18942619 UPF1 0.4 6.02 0.31 4.6e-9 Body mass index; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg18827738 chr6:112408577 TUBE1;C6orf225 0.45 6.25 0.33 1.28e-9 Anxiety disorder; CRC cis rs9393692 0.645 rs28446029 chr6:26305801 C/G cg00631329 chr6:26305371 NA -0.72 -13.02 -0.58 1.59e-31 Educational attainment; CRC cis rs4901869 0.966 rs431343 chr14:59345530 C/T cg02291164 chr14:59296302 NA 0.32 5.63 0.3 3.81e-8 Panic disorder; CRC cis rs6061231 1.000 rs13043313 chr20:60958269 A/G cg22601191 chr20:60968625 CABLES2 0.45 7.44 0.38 8.92e-13 Colorectal cancer; CRC trans rs7395662 0.591 rs11039766 chr11:48488715 T/C cg15704280 chr7:45808275 SEPT13 -0.49 -7.07 -0.36 9.09e-12 HDL cholesterol; CRC cis rs3823572 0.564 rs6949760 chr7:133676101 C/A cg03336402 chr7:133662267 EXOC4 -0.68 -9.97 -0.48 1.27e-20 Intelligence (multi-trait analysis); CRC cis rs9325144 0.581 rs2653758 chr12:38946233 G/T cg26384229 chr12:38710491 ALG10B -0.48 -6.98 -0.36 1.63e-11 Morning vs. evening chronotype; CRC cis rs10540 0.730 rs61877766 chr11:512973 T/G cg19913688 chr11:428466 ANO9 -0.69 -7.03 -0.36 1.22e-11 Body mass index; CRC cis rs2576037 0.901 rs2571021 chr18:44583498 A/G cg07416455 chr18:44543612 TCEB3CL;KATNAL2 0.42 6.38 0.33 5.94e-10 Personality dimensions; CRC cis rs6546324 0.625 rs2861681 chr2:67830139 A/G cg15745817 chr2:67799979 NA -0.55 -9.07 -0.45 1.1e-17 Endometriosis; CRC cis rs12745968 0.525 rs6603997 chr1:93062611 C/G cg17283838 chr1:93427260 FAM69A -0.45 -6.17 -0.32 2.06e-9 Bipolar disorder and schizophrenia; CRC cis rs62244186 0.541 rs9859879 chr3:44840166 G/A cg11003573 chr3:44754125 ZNF502 -0.33 -5.61 -0.3 4.33e-8 Depressive symptoms; CRC cis rs372883 0.506 rs2832301 chr21:30749712 G/A cg24692254 chr21:30365293 RNF160 0.54 8.44 0.42 1.03e-15 Pancreatic cancer; CRC cis rs1707322 0.656 rs3014210 chr1:46066608 A/G cg03146154 chr1:46216737 IPP -0.66 -9.37 -0.46 1.22e-18 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs10781543 0.810 rs11145756 chr9:139364585 A/G cg14019695 chr9:139328340 INPP5E 0.4 6.06 0.32 3.68e-9 Monocyte percentage of white cells; CRC cis rs6582630 0.576 rs4882258 chr12:38453686 C/T cg13010199 chr12:38710504 ALG10B -0.42 -6.01 -0.31 4.99e-9 Drug-induced liver injury (flucloxacillin); CRC cis rs7568458 0.660 rs55692129 chr2:85792404 A/T cg02493740 chr2:85810744 VAMP5 -0.54 -7.84 -0.4 6.49e-14 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); CRC cis rs1881797 0.932 rs4551631 chr1:247667663 C/T cg05639522 chr1:247681581 NA -0.51 -8.24 -0.41 4.12e-15 Acute lymphoblastic leukemia (childhood); CRC trans rs7395662 0.889 rs11517696 chr11:48940073 C/A cg21153622 chr11:89784906 NA -0.47 -7.4 -0.38 1.13e-12 HDL cholesterol; CRC cis rs9549367 0.713 rs4907598 chr13:113861385 C/T cg24300038 chr13:113819356 PROZ 0.49 6.37 0.33 6.44e-10 Platelet distribution width; CRC cis rs6694672 1.000 rs1170883 chr1:196951471 C/T cg13682187 chr1:196946512 CFHR5 -0.5 -7.68 -0.39 1.8e-13 Asthma; CRC cis rs2495707 0.624 rs2489008 chr10:102422934 C/T cg24024056 chr10:102415556 NA -0.36 -7.3 -0.37 2.17e-12 Body mass index; CRC cis rs28386778 0.863 rs2251164 chr17:61884120 G/A cg06873352 chr17:61820015 STRADA 0.77 14.5 0.62 3.45e-37 Prudent dietary pattern; CRC trans rs11252926 0.801 rs11252332 chr10:467318 A/T cg00953403 chr17:74099816 EXOC7 0.5 7.1 0.36 7.5e-12 Psychosis in Alzheimer's disease; CRC cis rs1448094 0.511 rs61930588 chr12:86158991 A/G cg19622623 chr12:86230825 RASSF9 -0.37 -5.73 -0.3 2.24e-8 Major depressive disorder; CRC cis rs7412746 0.611 rs72704679 chr1:150897477 C/T cg15448220 chr1:150897856 SETDB1 0.46 6.83 0.35 4.14e-11 Melanoma; CRC cis rs938554 0.692 rs4428284 chr4:9996392 A/T cg00071950 chr4:10020882 SLC2A9 0.49 6.45 0.33 4.04e-10 Blood metabolite levels; CRC cis rs7959452 0.590 rs6581889 chr12:69757429 T/C cg22834771 chr12:69754056 YEATS4 -0.53 -8.03 -0.4 1.79e-14 Blood protein levels; CRC cis rs1348850 0.793 rs13027299 chr2:178455501 T/G cg22681709 chr2:178499509 PDE11A -0.36 -6.54 -0.34 2.38e-10 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs2333194 0.846 rs6574118 chr14:73811992 A/G cg19682024 chr14:74008259 HEATR4;ACOT1 -0.41 -6.2 -0.32 1.65e-9 Bipolar disorder with mood-incongruent psychosis; CRC cis rs10751667 1.000 rs7927156 chr11:970607 A/G ch.11.42038R chr11:967971 AP2A2 0.61 9.35 0.46 1.4e-18 Alzheimer's disease (late onset); CRC cis rs13191362 1.000 rs13202339 chr6:163081812 G/A cg23758597 chr6:163146217 PARK2 -0.65 -6.52 -0.34 2.68e-10 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg01261044 chr14:35451962 SRP54 0.58 7.63 0.39 2.48e-13 Thyroid stimulating hormone; CRC cis rs7647973 1.000 rs3905330 chr3:49550774 A/G cg20833759 chr3:49053208 WDR6;DALRD3 0.53 8.24 0.41 4.06e-15 Menarche (age at onset); CRC cis rs9747201 0.962 rs34016823 chr17:80095428 G/T cg09264619 chr17:80180166 NA 0.51 7.3 0.37 2.17e-12 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs2075371 0.830 rs1421478 chr7:133922793 T/A cg02659138 chr7:134003124 SLC35B4 0.38 6.23 0.32 1.43e-9 Mean platelet volume; CRC cis rs11785693 0.862 rs62491189 chr8:4991309 T/C cg26367366 chr8:4980734 NA 0.83 9.87 0.48 2.67e-20 Neuroticism (multi-trait analysis);Neuroticism; CRC cis rs7811142 1.000 rs6979335 chr7:100089860 T/C cg00814883 chr7:100076585 TSC22D4 -0.79 -9.88 -0.48 2.44e-20 Platelet count; CRC cis rs9916302 0.904 rs2061342 chr17:37405657 T/G cg15445000 chr17:37608096 MED1 0.42 9.02 0.45 1.59e-17 Glomerular filtration rate (creatinine); CRC cis rs10206020 0.885 rs11887527 chr2:1578080 A/G cg26248373 chr2:1572462 NA -0.81 -11.92 -0.55 1.74e-27 IgG glycosylation; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg18459342 chr8:81084056 TPD52 0.42 6.65 0.34 1.21e-10 Liver disease severity in Alagille syndrome; CRC cis rs154659 0.887 rs154660 chr16:89667637 C/G cg01710450 chr16:89662404 CPNE7 -0.47 -6.48 -0.34 3.27e-10 Tanning; CRC cis rs2180341 1.000 rs7776136 chr6:127638348 A/T cg24812749 chr6:127587940 RNF146 0.91 13.19 0.59 3.58e-32 Breast cancer; CRC cis rs611744 0.538 rs2298605 chr8:109272006 T/C cg21045802 chr8:109455806 TTC35 0.46 7.03 0.36 1.21e-11 Dupuytren's disease; CRC cis rs1005277 0.540 rs2145487 chr10:38010077 A/G cg25427524 chr10:38739819 LOC399744 -0.73 -12.73 -0.57 1.88e-30 Extrinsic epigenetic age acceleration; CRC cis rs4234798 0.605 rs4689639 chr4:7213469 C/T cg18431297 chr4:7219810 SORCS2 -0.47 -7.31 -0.37 2.05e-12 Insulin-like growth factors; CRC cis rs9462027 0.628 rs2814953 chr6:34697767 A/G cg07306190 chr6:34760872 UHRF1BP1 -0.34 -6.05 -0.32 3.84e-9 Systemic lupus erythematosus; CRC cis rs2011503 1.000 rs80200208 chr19:19554725 C/T cg11584989 chr19:19387371 SF4 0.53 5.96 0.31 6.67e-9 Bipolar disorder; CRC cis rs11249608 0.600 rs13359570 chr5:178449249 T/G cg01312482 chr5:178451176 ZNF879 -0.36 -6.07 -0.32 3.55e-9 Pubertal anthropometrics; CRC cis rs11030122 0.632 rs10835556 chr11:4083013 A/G cg18678763 chr11:4115507 RRM1 -0.55 -8.89 -0.44 4.13e-17 Mean platelet volume;Platelet distribution width; CRC cis rs3018066 0.748 rs11097912 chr4:107000462 C/T cg01869342 chr4:106983673 TBCK 0.44 6.62 0.34 1.48e-10 Cancer; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg27043427 chr17:65362820 PSMD12 0.47 5.98 0.31 5.96e-9 Anxiety disorder; CRC cis rs9811920 0.809 rs4928153 chr3:99808445 G/A cg07805332 chr3:99536008 MIR548G;C3orf26 0.39 6.0 0.31 5.18e-9 Axial length; CRC cis rs2067615 0.524 rs10778499 chr12:107068387 C/T cg15890332 chr12:107067104 RFX4 0.32 5.7 0.3 2.67e-8 Heart rate; CRC cis rs12477438 0.520 rs7572660 chr2:99788582 A/G cg26064155 chr2:99771622 LIPT1;TSGA10 0.87 15.98 0.66 6.08e-43 Chronic sinus infection; CRC cis rs394563 0.591 rs237018 chr6:149743930 A/G cg03678062 chr6:149772716 ZC3H12D -0.34 -6.33 -0.33 8.23e-10 Dupuytren's disease; CRC cis rs10504229 0.953 rs57131327 chr8:58171895 T/C cg24829409 chr8:58192753 C8orf71 -0.68 -11.34 -0.53 2.27e-25 Developmental language disorder (linguistic errors); CRC trans rs1376359 0.673 rs7543104 chr1:103126190 C/A cg16220183 chr17:56609687 SEPT4 -0.45 -6.03 -0.32 4.48e-9 QRS duration in Tripanosoma cruzi seropositivity; CRC cis rs875971 1.000 rs10244498 chr7:66116056 A/G cg18912574 chr7:65842487 NCRNA00174 0.36 6.11 0.32 2.84e-9 Aortic root size; CRC cis rs7607369 0.536 rs7600248 chr2:219665963 C/T cg02176678 chr2:219576539 TTLL4 -0.37 -6.13 -0.32 2.46e-9 Red blood cell count;Amyotrophic lateral sclerosis; CRC cis rs8016982 0.674 rs8004096 chr14:81701082 T/G cg01989461 chr14:81687754 GTF2A1 0.56 8.75 0.43 1.15e-16 Schizophrenia; CRC cis rs73206853 0.764 rs3026425 chr12:110688168 A/G cg12870014 chr12:110450643 ANKRD13A 0.86 10.4 0.5 4.27e-22 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg03090513 chr2:208394450 CREB1 0.4 6.61 0.34 1.57e-10 Liver disease severity in Alagille syndrome; CRC cis rs875971 1.000 rs11971949 chr7:65626014 A/G cg18876405 chr7:65276391 NA -0.53 -8.97 -0.44 2.27e-17 Aortic root size; CRC cis rs1368882 1.000 rs1368882 chr1:55107019 A/G cg01517571 chr1:55089959 ACOT11;FAM151A -0.53 -7.47 -0.38 7.41e-13 Non-substance related behavioral disinhibition; CRC cis rs589448 0.902 rs642786 chr12:69758462 T/C cg20891283 chr12:69753455 YEATS4 0.98 21.22 0.76 1.46e-63 Cerebrospinal fluid biomarker levels; CRC cis rs6088580 0.634 rs2184836 chr20:32963369 A/G cg24642439 chr20:33292090 TP53INP2 -0.38 -6.41 -0.33 5.08e-10 Glomerular filtration rate (creatinine); CRC cis rs10504229 0.906 rs58559296 chr8:58171714 T/C cg02290350 chr8:58132656 NA -0.42 -5.96 -0.31 6.62e-9 Developmental language disorder (linguistic errors); CRC trans rs11165623 0.602 rs7527155 chr1:97016690 T/C cg10631902 chr5:14652156 NA -0.36 -6.17 -0.32 2.05e-9 Hip circumference;Waist circumference; CRC trans rs7395662 1.000 rs11039821 chr11:48562875 T/C cg21153622 chr11:89784906 NA -0.44 -7.11 -0.36 7.07e-12 HDL cholesterol; CRC cis rs4900538 0.821 rs12586673 chr14:102827643 C/T cg18135206 chr14:102964638 TECPR2 -0.97 -16.6 -0.68 2.2e-45 Mean corpuscular volume;Mean corpuscular hemoglobin; CRC cis rs9487051 0.872 rs9374079 chr6:109609619 A/G cg21918786 chr6:109611834 NA -0.45 -8.32 -0.42 2.32e-15 Reticulocyte fraction of red cells; CRC cis rs644799 1.000 rs544119 chr11:95538624 G/A cg25478527 chr11:95522999 CEP57;FAM76B 0.51 7.69 0.39 1.68e-13 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs12230513 0.732 rs4343668 chr12:55868936 G/T cg19537932 chr12:55886519 OR6C68 -0.71 -8.99 -0.44 1.95e-17 Contrast sensitivity; CRC cis rs7949030 0.626 rs71490390 chr11:62329185 A/G cg11742103 chr11:62369870 EML3;MTA2 0.62 11.85 0.55 3.28e-27 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; CRC cis rs13191362 0.810 rs35509380 chr6:163053028 A/G cg21926612 chr6:163149169 PACRG;PARK2 0.98 12.61 0.57 5.13e-30 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs7552404 1.000 rs11161515 chr1:76212559 C/T cg10523679 chr1:76189770 ACADM 0.84 11.52 0.54 4.86e-26 Blood metabolite levels;Acylcarnitine levels; CRC cis rs6502050 0.699 rs9901808 chr17:80107814 C/T cg13198984 chr17:80129470 CCDC57 0.46 8.15 0.41 7.64e-15 Life satisfaction; CRC trans rs2303319 0.504 rs62189052 chr2:162623869 C/G cg25193742 chr10:104614220 C10orf32 -0.76 -6.46 -0.34 3.66e-10 Cognitive function; CRC cis rs6502050 0.835 rs7220639 chr17:80146866 G/A cg09264619 chr17:80180166 NA -0.35 -5.81 -0.31 1.48e-8 Life satisfaction; CRC cis rs5769765 0.825 rs7511620 chr22:50307932 T/C cg22709217 chr22:50311962 ALG12;CRELD2 -1.08 -18.1 -0.71 2.56e-51 Schizophrenia; CRC cis rs3767633 0.925 rs2055539 chr1:161807866 T/C cg09175582 chr1:161736000 ATF6 0.69 6.27 0.33 1.14e-9 IgG glycosylation; CRC cis rs7937682 0.855 rs490897 chr11:111487914 A/G cg19812747 chr11:111475976 SIK2 -0.58 -9.92 -0.48 1.8e-20 Primary sclerosing cholangitis; CRC cis rs1218582 0.804 rs869506 chr1:154859581 A/C cg06221963 chr1:154839813 KCNN3 -0.78 -15.86 -0.66 1.81e-42 Prostate cancer; CRC cis rs977987 0.843 rs4888372 chr16:75313485 G/A cg03315344 chr16:75512273 CHST6 0.51 8.78 0.44 9e-17 Dupuytren's disease; CRC cis rs896854 0.654 rs28591375 chr8:95973637 C/G cg09323728 chr8:95962352 TP53INP1 -0.45 -7.47 -0.38 7.43e-13 Type 2 diabetes; CRC cis rs6964587 0.967 rs2188153 chr7:91595117 G/T cg17063962 chr7:91808500 NA 0.8 14.25 0.62 3.19e-36 Breast cancer; CRC cis rs9311474 0.607 rs4687625 chr3:52563718 C/T cg08222913 chr3:52553049 STAB1 -0.37 -6.98 -0.36 1.67e-11 Electroencephalogram traits; CRC cis rs11711311 0.868 rs13091621 chr3:113481977 A/G cg15478005 chr3:113465772 ATP6V1A;NAA50 0.42 5.87 0.31 1.08e-8 IgG glycosylation; CRC trans rs2303319 0.504 rs12467613 chr2:162603216 G/T cg10498984 chr16:28874827 SH2B1 -0.73 -6.3 -0.33 9.75e-10 Cognitive function; CRC cis rs7552404 0.727 rs6678348 chr1:76332463 C/T cg10523679 chr1:76189770 ACADM 0.69 8.89 0.44 4.24e-17 Blood metabolite levels;Acylcarnitine levels; CRC cis rs3889199 0.629 rs7526027 chr1:59683994 T/C cg25881383 chr1:59680599 NA -0.38 -6.23 -0.32 1.41e-9 Pulse pressure; CRC cis rs796364 0.789 rs176008 chr2:200814720 A/T cg12253985 chr2:200820533 C2orf60;C2orf47 0.59 6.55 0.34 2.19e-10 Schizophrenia; CRC cis rs2153535 0.601 rs7741024 chr6:8530313 T/C cg07606381 chr6:8435919 SLC35B3 0.67 10.85 0.51 1.15e-23 Motion sickness; CRC cis rs7833790 0.724 rs1054078 chr8:82712153 A/G cg27398817 chr8:82754497 SNX16 -0.43 -5.88 -0.31 1.02e-8 Diastolic blood pressure; CRC cis rs4819052 1.000 rs2297285 chr21:46705621 A/G cg11663144 chr21:46675770 NA 0.74 10.14 0.49 3.29e-21 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs6500395 0.890 rs9936271 chr16:48601291 A/G cg04672837 chr16:48644449 N4BP1 0.45 6.77 0.35 5.94e-11 Response to tocilizumab in rheumatoid arthritis; CRC trans rs2795502 1.000 rs2795502 chr10:43340662 G/A cg06791473 chr12:49259579 RND1 0.61 5.99 0.31 5.45e-9 Blood protein levels; CRC cis rs7613875 0.641 rs6793528 chr3:50100188 C/A cg24110177 chr3:50126178 RBM5 0.59 9.22 0.45 3.55e-18 Body mass index; CRC cis rs9443645 0.509 rs9361459 chr6:79572922 A/G cg05283184 chr6:79620031 NA 0.43 6.25 0.33 1.28e-9 Intelligence (multi-trait analysis); CRC trans rs853679 0.607 rs34661125 chr6:28281894 G/A cg06606381 chr12:133084897 FBRSL1 -1.44 -10.94 -0.52 5.61e-24 Depression; CRC cis rs9814567 1.000 rs9864439 chr3:134298671 T/C cg06109529 chr3:134205091 CEP63;ANAPC13 -0.8 -11.7 -0.54 1.13e-26 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs7715806 0.500 rs4704233 chr5:75000792 G/A cg00601450 chr5:74908170 NA 0.46 5.85 0.31 1.21e-8 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs8072100 0.738 rs3736438 chr17:45486651 T/G cg08085267 chr17:45401833 C17orf57 -0.58 -8.75 -0.43 1.11e-16 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs7666738 0.830 rs7679299 chr4:99057620 C/A cg17366294 chr4:99064904 C4orf37 0.45 7.71 0.39 1.51e-13 Colonoscopy-negative controls vs population controls; CRC trans rs10002492 0.666 rs11727304 chr4:12480889 A/G cg05702448 chr1:167905194 DCAF6;BRP44 0.46 5.96 0.31 6.54e-9 IgG glycosylation; CRC cis rs540254 0.619 rs4656932 chr1:160779495 C/T cg20255094 chr1:160771763 LY9 0.43 5.9 0.31 8.83e-9 Blood protein levels; CRC cis rs7259376 0.593 rs1091180 chr19:22476882 G/T cg02657401 chr19:22469223 NA 0.3 6.56 0.34 2.07e-10 Menopause (age at onset); CRC cis rs2576037 0.526 rs998819 chr18:44564181 C/T cg07643061 chr18:44555308 TCEB3C;TCEB3CL;KATNAL2 0.34 5.68 0.3 3.03e-8 Personality dimensions; CRC cis rs9368481 0.569 rs6907403 chr6:26877297 A/C cg18867708 chr6:26865862 GUSBL1 0.42 6.02 0.32 4.59e-9 Autism spectrum disorder or schizophrenia; CRC trans rs1945213 0.694 rs9888298 chr11:55865704 T/C cg03929089 chr4:120376271 NA 0.59 6.64 0.34 1.26e-10 Acute lymphoblastic leukemia (childhood); CRC cis rs1799949 1.000 rs12944430 chr17:41330820 C/G cg19454999 chr17:41278357 BRCA1;NBR2 0.54 8.25 0.41 3.98e-15 Menopause (age at onset); CRC cis rs7618501 0.633 rs2883057 chr3:49998282 C/T cg24308560 chr3:49941425 MST1R -0.51 -8.22 -0.41 4.81e-15 Intelligence (multi-trait analysis); CRC trans rs1005277 0.579 rs2504143 chr10:38383706 C/T cg11292332 chr7:45801988 SEPT13 -0.36 -6.32 -0.33 8.73e-10 Extrinsic epigenetic age acceleration; CRC trans rs875971 0.545 rs12670811 chr7:65823019 C/A cg02869306 chr7:64672164 INTS4L1 -0.42 -6.1 -0.32 3.04e-9 Aortic root size; CRC cis rs4665809 1.000 rs11678157 chr2:26321526 T/C cg27170947 chr2:26402098 FAM59B -0.45 -6.13 -0.32 2.55e-9 Gut microbiome composition (summer); CRC cis rs1577917 0.958 rs12665542 chr6:86544443 G/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.55 -6.8 -0.35 4.89e-11 Response to antipsychotic treatment; CRC cis rs12618769 0.625 rs78518453 chr2:99213899 T/C cg18455616 chr2:99124870 INPP4A 0.35 5.82 0.31 1.41e-8 Bipolar disorder; CRC cis rs2014572 0.967 rs11667407 chr19:57763122 C/T cg24459738 chr19:57751996 ZNF805 -0.56 -8.9 -0.44 3.82e-17 Hyperactive-impulsive symptoms; CRC cis rs57561814 0.510 rs1524107 chr7:22768219 C/T cg26061582 chr7:22766209 IL6 0.94 6.98 0.36 1.68e-11 Tonsillectomy; CRC cis rs2949837 0.655 rs11977526 chr7:46008110 G/A cg04796162 chr7:45961102 IGFBP3 0.47 7.87 0.4 5.24e-14 Sitting height ratio; CRC cis rs6815814 0.950 rs11722813 chr4:38810769 C/T cg06935464 chr4:38784597 TLR10 0.55 5.66 0.3 3.27e-8 Breast cancer; CRC cis rs9911578 1.000 rs4482353 chr17:56896834 A/G cg12560992 chr17:57184187 TRIM37 0.9 16.65 0.68 1.44e-45 Intelligence (multi-trait analysis); CRC cis rs1005224 0.926 rs7143743 chr14:76127805 G/C cg25116370 chr14:76127843 TTLL5;C14orf1 -0.46 -6.93 -0.36 2.24e-11 Large artery stroke; CRC cis rs8180040 0.620 rs9858443 chr3:47086048 G/A cg10298567 chr3:47292165 KIF9 -0.39 -6.15 -0.32 2.2e-9 Colorectal cancer; CRC cis rs11711311 1.000 rs3806641 chr3:113465761 T/G cg15478005 chr3:113465772 ATP6V1A;NAA50 0.45 6.19 0.32 1.8e-9 IgG glycosylation; CRC cis rs2070488 0.930 rs2370840 chr3:38529825 C/T cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.94 17.81 0.7 3.55e-50 Electrocardiographic conduction measures; CRC cis rs6951245 1.000 rs78628466 chr7:1068453 G/C cg18402987 chr7:1209562 NA 0.64 6.77 0.35 6.03e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs1799949 1.000 rs8176234 chr17:41219780 T/C cg23758822 chr17:41437982 NA 0.81 13.64 0.6 7.09e-34 Menopause (age at onset); CRC cis rs9649213 0.593 rs3801264 chr7:97950620 A/G cg08684580 chr7:98029266 BAIAP2L1 -0.31 -5.62 -0.3 4.03e-8 Prostate cancer (SNP x SNP interaction); CRC cis rs1552244 0.572 rs66514627 chr3:10166632 A/C cg02579736 chr3:10068473 FANCD2;CIDECP 1.01 11.58 0.54 2.98e-26 Alzheimer's disease; CRC cis rs853679 0.517 rs1947863 chr6:28099344 G/A cg02631126 chr6:28058918 ZSCAN12L1 0.29 5.89 0.31 9.41e-9 Depression; CRC cis rs3771570 1.000 rs41266959 chr2:242275579 G/A cg21155796 chr2:242212141 HDLBP 0.62 6.65 0.34 1.25e-10 Prostate cancer; CRC cis rs2976388 1.000 rs2920293 chr8:143765414 C/G cg22687807 chr8:143858763 LYNX1 -0.38 -6.67 -0.35 1.1e-10 Urinary tract infection frequency; CRC cis rs1862618 0.853 rs10051747 chr5:56083289 C/A cg24531977 chr5:56204891 C5orf35 -0.84 -11.25 -0.53 4.62e-25 Initial pursuit acceleration; CRC cis rs919433 0.783 rs788007 chr2:198233676 T/G cg03934865 chr2:198174659 NA 0.36 5.82 0.31 1.42e-8 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC trans rs2980439 0.818 rs2948294 chr8:8094961 A/G cg16141378 chr3:129829833 LOC729375 -0.48 -7.04 -0.36 1.11e-11 Neuroticism; CRC cis rs875971 0.545 rs316316 chr7:65614257 C/T cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.61 -7.93 -0.4 3.42e-14 Aortic root size; CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg16647868 chr5:131706066 SLC22A5 -0.46 -6.1 -0.32 2.93e-9 Diisocyanate-induced asthma; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg14823287 chr2:74684720 WBP1;INO80B 0.47 6.22 0.32 1.5e-9 Anxiety disorder; CRC cis rs9522267 0.535 rs7339347 chr13:112237920 C/T cg14352298 chr13:112236639 NA 0.29 6.57 0.34 1.95e-10 Hepatitis; CRC cis rs7605827 0.930 rs10179765 chr2:15541249 C/T cg19274914 chr2:15703543 NA 0.4 5.94 0.31 7.2e-9 Educational attainment (years of education); CRC cis rs2243480 1.000 rs35820085 chr7:65442758 C/T cg12463550 chr7:65579703 CRCP 0.66 6.24 0.33 1.31e-9 Diabetic kidney disease; CRC cis rs10504229 1.000 rs67188507 chr8:58187492 A/T cg02290350 chr8:58132656 NA -0.42 -5.96 -0.31 6.62e-9 Developmental language disorder (linguistic errors); CRC cis rs769267 0.896 rs2315610 chr19:19597240 T/C cg01262667 chr19:19385393 TM6SF2 0.36 5.88 0.31 1.01e-8 Tonsillectomy; CRC cis rs6433857 0.657 rs2368177 chr2:181501242 T/C cg23363182 chr2:181467187 NA -0.58 -9.49 -0.46 5.01e-19 Body mass index; CRC cis rs9381040 0.674 rs4711657 chr6:41162715 G/A cg04346459 chr6:41068666 NFYA;LOC221442 -0.54 -7.95 -0.4 2.92e-14 Alzheimer's disease (late onset); CRC cis rs4803480 0.720 rs4141218 chr19:42081907 T/C cg08478046 chr19:42093086 CEACAM21 -0.32 -6.09 -0.32 3.17e-9 Schizophrenia; CRC cis rs6764363 0.778 rs17012663 chr3:285806 G/T cg02057681 chr3:285234 CHL1 -0.39 -5.61 -0.3 4.22e-8 Sudden cardiac arrest; CRC cis rs4820539 0.902 rs4822359 chr22:23474972 A/G cg14186256 chr22:23484241 RTDR1 0.9 17.49 0.69 6.72e-49 Bone mineral density; CRC cis rs7523050 0.643 rs67091034 chr1:109402567 C/G cg08274380 chr1:109419600 GPSM2 0.85 6.65 0.34 1.24e-10 Fat distribution (HIV); CRC cis rs7945705 0.870 rs4929922 chr11:8975776 A/G cg12365402 chr11:9010492 NRIP3 -0.45 -6.87 -0.35 3.31e-11 Hemoglobin concentration; CRC cis rs10992471 0.756 rs3758229 chr9:95078852 G/T cg14631576 chr9:95140430 CENPP -0.39 -7.2 -0.37 4.23e-12 Visceral adipose tissue/subcutaneous adipose tissue ratio; CRC cis rs1065852 0.503 rs9620006 chr22:42399547 T/A cg00645731 chr22:42541494 CYP2D7P1 0.39 6.63 0.34 1.39e-10 Response to serotonin reuptake inhibitors in major depressive disorder (plasma drug and metabolite levels); CRC cis rs1499614 1.000 rs1267818 chr7:66107024 C/T cg25985355 chr7:65971099 NA -0.51 -5.77 -0.3 1.79e-8 Gout; CRC cis rs4713118 0.591 rs2056924 chr6:27690174 G/A cg03623178 chr6:28175578 NA 0.59 8.35 0.42 1.96e-15 Parkinson's disease; CRC cis rs3540 0.960 rs4031435 chr15:91015566 G/C cg22089800 chr15:90895588 ZNF774 0.48 7.61 0.39 2.9e-13 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; CRC cis rs1801251 0.711 rs778368 chr2:233745333 G/C cg25237894 chr2:233734115 C2orf82 -0.61 -10.7 -0.51 3.96e-23 Coronary artery disease; CRC cis rs548181 0.673 rs12288034 chr11:125570941 A/T cg03464685 chr11:125439445 EI24 -1.08 -11.45 -0.53 8.94e-26 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs6546324 0.625 rs2902024 chr2:67836718 T/C cg15745817 chr2:67799979 NA -0.44 -7.92 -0.4 3.79e-14 Endometriosis; CRC cis rs1568889 0.877 rs12786351 chr11:28271122 A/G cg06544937 chr11:28130018 METT5D1;KIF18A 0.7 7.84 0.4 6.28e-14 Bipolar disorder; CRC cis rs1046896 0.553 rs8073413 chr17:80836005 G/A cg16060761 chr17:80687452 NA -0.45 -5.77 -0.3 1.85e-8 Glycated hemoglobin levels; CRC cis rs7044106 0.791 rs10984994 chr9:123478769 A/T cg09419670 chr9:123605666 PSMD5;LOC253039 -0.68 -10.51 -0.5 1.76e-22 Hip circumference adjusted for BMI; CRC cis rs35306767 0.903 rs10904577 chr10:922077 A/G cg26597838 chr10:835615 NA 0.94 11.56 0.54 3.59e-26 Eosinophil percentage of granulocytes; CRC cis rs11252926 0.931 rs4881399 chr10:567325 A/G cg18196295 chr10:418757 DIP2C 0.45 6.52 0.34 2.59e-10 Psychosis in Alzheimer's disease; CRC cis rs11212617 1.000 rs619972 chr11:108169619 C/T cg14761454 chr11:108092087 ATM;NPAT 0.39 5.6 0.3 4.49e-8 Response to metformin in type 2 diabetes (glycemic); CRC trans rs13046373 0.905 rs4816372 chr21:32077414 A/T cg17143303 chr17:33734764 NA -0.4 -5.99 -0.31 5.35e-9 HDL cholesterol; CRC cis rs8180040 0.800 rs56250009 chr3:47279497 G/C cg27129171 chr3:47204927 SETD2 -0.68 -10.39 -0.5 4.54e-22 Colorectal cancer; CRC cis rs1150668 0.830 rs2859365 chr6:28391465 C/T cg03623178 chr6:28175578 NA -0.49 -7.25 -0.37 2.9e-12 Pubertal anthropometrics; CRC cis rs10504229 0.683 rs17194529 chr8:58105647 A/G cg08219700 chr8:58056026 NA 0.59 6.98 0.36 1.68e-11 Developmental language disorder (linguistic errors); CRC trans rs931812 0.756 rs4734497 chr8:101934971 T/C cg20993868 chr7:22813445 NA 0.42 7.74 0.39 1.25e-13 Attention deficit hyperactivity disorder and conduct disorder; CRC cis rs7918232 0.941 rs1775350 chr10:27441973 C/T cg14442939 chr10:27389572 ANKRD26 -0.82 -9.06 -0.45 1.15e-17 Breast cancer; CRC cis rs1003719 0.788 rs4817845 chr21:38447132 T/C cg10648535 chr21:38446584 PIGP;TTC3 0.53 7.58 0.39 3.56e-13 Eye color traits; CRC cis rs798554 0.607 rs1182151 chr7:2909225 C/G cg13628971 chr7:2884303 GNA12 0.46 5.99 0.31 5.55e-9 Height; CRC trans rs2303319 0.504 rs55650699 chr2:162388931 T/C cg09481857 chr22:21368659 P2RX6;MGC16703 -0.64 -6.1 -0.32 3.04e-9 Cognitive function; CRC cis rs2985684 0.895 rs4900940 chr14:50075310 A/C cg04989706 chr14:50066350 PPIL5 -0.61 -8.24 -0.41 4.18e-15 Carotid intima media thickness; CRC cis rs9517320 0.515 rs4772099 chr13:99196121 A/C cg20487152 chr13:99095054 FARP1 -0.46 -6.66 -0.34 1.14e-10 Longevity; CRC cis rs10991814 0.920 rs7874056 chr9:94087622 A/C cg14446406 chr9:93919335 NA 0.59 6.78 0.35 5.66e-11 Neutrophil percentage of granulocytes; CRC cis rs853679 0.517 rs9348796 chr6:28126202 A/G cg12963246 chr6:28129442 ZNF389 0.49 5.7 0.3 2.71e-8 Depression; CRC cis rs7927771 1.000 rs10838747 chr11:47716324 G/C cg18512352 chr11:47633146 NA -0.49 -9.62 -0.47 1.75e-19 Subjective well-being; CRC cis rs5769765 0.779 rs12170530 chr22:50318422 T/G cg22709217 chr22:50311962 ALG12;CRELD2 -1.06 -15.43 -0.65 8.48e-41 Schizophrenia; CRC cis rs172166 0.637 rs1071893 chr6:28167635 G/C cg10876282 chr6:28092338 ZSCAN16 0.49 6.78 0.35 5.55e-11 Cardiac Troponin-T levels; CRC cis rs4731207 0.698 rs12533560 chr7:124561882 T/C cg23710748 chr7:124431027 NA -0.37 -5.99 -0.31 5.5e-9 Cutaneous malignant melanoma; CRC cis rs9325144 0.560 rs11183046 chr12:38655270 A/T cg13010199 chr12:38710504 ALG10B -0.42 -6.12 -0.32 2.7e-9 Morning vs. evening chronotype; CRC cis rs4285028 0.747 rs7153 chr3:121383297 G/A cg20356878 chr3:121714668 ILDR1 -0.43 -6.1 -0.32 3e-9 Multiple sclerosis; CRC cis rs17826219 0.500 rs28452421 chr17:29083980 G/A cg13385521 chr17:29058706 SUZ12P 0.73 8.4 0.42 1.39e-15 Body mass index; CRC cis rs11190604 1.000 rs2489043 chr10:102334327 T/C cg07080220 chr10:102295463 HIF1AN 0.48 6.15 0.32 2.31e-9 Palmitoleic acid (16:1n-7) levels; CRC cis rs7394190 0.748 rs11000771 chr10:75524458 T/G cg07699608 chr10:75541558 CHCHD1 0.58 6.11 0.32 2.89e-9 Incident atrial fibrillation; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg22757384 chr3:183353803 KLHL24 0.45 6.42 0.33 4.85e-10 Response to antipsychotic treatment; CRC cis rs9325144 0.647 rs12229104 chr12:39110811 T/A cg26384229 chr12:38710491 ALG10B -0.52 -7.34 -0.37 1.74e-12 Morning vs. evening chronotype; CRC cis rs1451375 0.572 rs896309 chr7:50545022 A/G cg18232548 chr7:50535776 DDC -0.43 -5.62 -0.3 4.05e-8 Malaria; CRC cis rs826838 0.651 rs12367384 chr12:38618460 G/T cg26384229 chr12:38710491 ALG10B 0.55 7.45 0.38 8.5e-13 Heart rate; CRC cis rs875971 0.862 rs12698526 chr7:65969105 T/C cg18252515 chr7:66147081 NA -0.43 -6.18 -0.32 1.93e-9 Aortic root size; CRC cis rs6693567 0.565 rs1260404 chr1:150304150 T/A cg15654264 chr1:150340011 RPRD2 0.37 5.81 0.31 1.46e-8 Migraine; CRC cis rs929596 0.556 rs10202865 chr2:234587707 C/T cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.48 -7.18 -0.37 4.62e-12 Total bilirubin levels in HIV-1 infection; CRC cis rs4713118 0.629 rs172165 chr6:28020814 T/G cg06470822 chr6:28175283 NA 0.91 13.28 0.59 1.54e-32 Parkinson's disease; CRC cis rs7772486 0.686 rs10872579 chr6:145966012 C/G cg13319975 chr6:146136371 FBXO30 -0.4 -5.95 -0.31 6.77e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs9914988 0.943 rs2043032 chr17:27136692 A/G cg20469991 chr17:27169893 C17orf63 -0.67 -7.38 -0.38 1.32e-12 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs28386778 0.863 rs4968661 chr17:61796306 A/G cg06601766 chr17:61851465 DDX42;CCDC47 0.44 6.0 0.31 5.3300000000000004e-09 Prudent dietary pattern; CRC cis rs372883 0.648 rs2832297 chr21:30742996 A/C cg08807101 chr21:30365312 RNF160 0.54 7.56 0.38 4.02e-13 Pancreatic cancer; CRC cis rs7119 0.678 rs12914098 chr15:77823013 C/T cg27398640 chr15:77910606 LINGO1 -0.44 -7.53 -0.38 4.89e-13 Type 2 diabetes; CRC cis rs2160860 0.745 rs3739319 chr8:39785321 C/T cg11363097 chr8:39792086 IDO2 -0.39 -6.63 -0.34 1.35e-10 Blood metabolite levels; CRC cis rs10992471 0.756 rs7848055 chr9:95115492 A/C cg13798575 chr9:95087839 CENPP;NOL8 -0.48 -6.88 -0.35 3.02e-11 Visceral adipose tissue/subcutaneous adipose tissue ratio; CRC cis rs6061231 0.556 rs6121571 chr20:60977323 T/G cg22601191 chr20:60968625 CABLES2 0.36 6.18 0.32 1.88e-9 Colorectal cancer; CRC cis rs4660306 0.677 rs781060 chr1:45934166 C/T cg03123370 chr1:45965343 CCDC163P;MMACHC 0.48 6.48 0.34 3.37e-10 Homocysteine levels; CRC cis rs2797160 1.000 rs1739357 chr6:126019655 T/G cg05901451 chr6:126070800 HEY2 0.43 6.58 0.34 1.82e-10 Endometrial cancer; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg13904493 chr1:233464194 KIAA1804 0.45 6.42 0.33 4.84e-10 Anxiety disorder; CRC cis rs7607369 0.536 rs12623007 chr2:219665335 T/C cg02176678 chr2:219576539 TTLL4 -0.39 -6.36 -0.33 6.89e-10 Red blood cell count;Amyotrophic lateral sclerosis; CRC cis rs7224685 0.501 rs781845 chr17:3958341 A/G cg10724054 chr17:3904396 NA 0.42 6.88 0.35 3.06e-11 Type 2 diabetes; CRC cis rs2760061 0.819 rs708115 chr1:228198046 C/T cg02753203 chr1:228287806 NA 0.69 10.74 0.51 2.99e-23 Diastolic blood pressure; CRC cis rs12477438 0.798 rs10202452 chr2:99569409 T/C cg26064155 chr2:99771622 LIPT1;TSGA10 -0.74 -10.46 -0.5 2.73e-22 Chronic sinus infection; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg05676562 chr16:30102457 TBX6 -0.36 -6.25 -0.33 1.27e-9 Liver disease severity in Alagille syndrome; CRC cis rs853679 0.517 rs2273564 chr6:28057594 A/T cg02631126 chr6:28058918 ZSCAN12L1 0.3 6.09 0.32 3.18e-9 Depression; CRC cis rs9611565 0.694 rs202637 chr22:41853928 A/G cg03806693 chr22:41940476 POLR3H 0.97 11.11 0.52 1.49e-24 Vitiligo; CRC cis rs4563143 0.663 rs10406794 chr19:29228056 C/T cg12756686 chr19:29218302 NA 0.65 10.27 0.49 1.19e-21 Methadone dose in opioid dependence; CRC cis rs9322193 0.923 rs9688938 chr6:150110077 G/A cg00933542 chr6:150070202 PCMT1 0.28 5.63 0.3 3.86e-8 Lung cancer; CRC cis rs6461049 0.800 rs3778977 chr7:2159746 C/T cg08027265 chr7:2291960 NA -0.36 -6.05 -0.32 4e-9 Schizophrenia; CRC cis rs11608355 0.515 rs12579916 chr12:109924528 T/G cg05360138 chr12:110035743 NA 0.77 8.62 0.43 2.95e-16 Neuroticism; CRC cis rs2404602 0.684 rs965818 chr15:76866785 T/C cg03037974 chr15:76606532 NA -0.52 -7.89 -0.4 4.59e-14 Blood metabolite levels; CRC cis rs6502050 0.835 rs8065210 chr17:80090960 G/A cg09264619 chr17:80180166 NA -0.36 -6.04 -0.32 4.23e-9 Life satisfaction; CRC trans rs2303319 0.504 rs62189041 chr2:162599506 T/C cg12500891 chr11:57225987 NA -0.65 -6.06 -0.32 3.77e-9 Cognitive function; CRC cis rs514406 0.929 rs557715 chr1:53321593 C/G cg25767906 chr1:53392781 SCP2 -0.46 -7.59 -0.39 3.41e-13 Monocyte count; CRC cis rs5758659 0.714 rs5751220 chr22:42516205 A/C cg25452165 chr22:42524984 CYP2D6 -0.4 -5.7 -0.3 2.69e-8 Cognitive function; CRC trans rs7604735 0.853 rs12474485 chr2:145810833 A/C cg26010734 chr19:15344046 EPHX3 -0.37 -5.98 -0.31 5.79e-9 Coronary artery disease; CRC cis rs1448094 0.511 rs4278581 chr12:86151054 A/G cg19622623 chr12:86230825 RASSF9 0.4 6.15 0.32 2.22e-9 Major depressive disorder; CRC cis rs7666738 0.830 rs13328042 chr4:99055406 A/G cg17366294 chr4:99064904 C4orf37 0.45 7.72 0.39 1.44e-13 Colonoscopy-negative controls vs population controls; CRC cis rs4665809 0.941 rs1470096 chr2:26311482 T/C cg26119090 chr2:26468346 HADHA;HADHB -0.65 -8.04 -0.41 1.65e-14 Gut microbiome composition (summer); CRC cis rs185694 1.000 rs200505 chr13:30900868 G/T cg07600127 chr13:30881527 KATNAL1 -0.57 -6.05 -0.32 4.01e-9 Antineutrophil cytoplasmic antibody-associated vasculitis; CRC cis rs10791323 0.569 rs2282601 chr11:133712594 C/G cg15485101 chr11:133734466 NA 0.44 7.54 0.38 4.53e-13 Childhood ear infection; CRC cis rs11212617 0.967 rs583725 chr11:108165075 A/G cg12106634 chr11:108092400 ATM;NPAT 0.42 6.07 0.32 3.56e-9 Response to metformin in type 2 diabetes (glycemic); CRC cis rs2976388 0.590 rs13254346 chr8:143823863 G/C cg05569086 chr8:143859399 LYNX1 -0.39 -6.43 -0.33 4.54e-10 Urinary tract infection frequency; CRC cis rs2404602 0.716 rs12592171 chr15:76755133 G/C cg22467129 chr15:76604101 ETFA -0.45 -7.71 -0.39 1.46e-13 Blood metabolite levels; CRC trans rs4478147 0.569 rs72665740 chr4:87459950 C/T cg01215037 chr19:50083917 PRRG2;NOSIP 0.45 5.97 0.31 6.1e-9 Migraine - clinic-based; CRC cis rs2075371 1.000 rs2544221 chr7:133993014 G/C cg11752832 chr7:134001865 SLC35B4 0.5 7.6 0.39 3.07e-13 Mean platelet volume; CRC cis rs17376456 1.000 rs12188453 chr5:93560807 G/T cg25358565 chr5:93447407 FAM172A -1.06 -10.04 -0.48 7.5e-21 Diabetic retinopathy; CRC cis rs2840044 1.000 rs225277 chr17:33973311 G/A cg05299278 chr17:33885742 SLFN14 0.41 6.11 0.32 2.76e-9 Response to radiotherapy in cancer (late toxicity); CRC cis rs2153535 0.601 rs1928183 chr6:8530018 A/G cg21535247 chr6:8435926 SLC35B3 0.49 7.52 0.38 5.18e-13 Motion sickness; CRC cis rs4713118 0.539 rs200967 chr6:27862127 A/G cg06470822 chr6:28175283 NA 0.78 11.17 0.52 8.89e-25 Parkinson's disease; CRC cis rs951366 0.646 rs1772159 chr1:205759195 G/A cg14159672 chr1:205819179 PM20D1 0.89 13.6 0.6 9.75e-34 Menarche (age at onset); CRC cis rs1552244 0.882 rs67762674 chr3:10014485 C/T cg02579736 chr3:10068473 FANCD2;CIDECP 0.95 12.29 0.56 7.75e-29 Alzheimer's disease; CRC cis rs11764590 0.715 rs11760737 chr7:2104055 T/C cg02825527 chr7:2087843 MAD1L1 -0.51 -6.15 -0.32 2.26e-9 Neuroticism; CRC cis rs172166 0.516 rs1225618 chr6:28129713 A/C cg03623178 chr6:28175578 NA 0.65 9.92 0.48 1.85e-20 Cardiac Troponin-T levels; CRC cis rs1862618 0.853 rs866222 chr5:56184444 T/C cg12311346 chr5:56204834 C5orf35 -0.79 -10.04 -0.48 7.48e-21 Initial pursuit acceleration; CRC cis rs2346177 0.844 rs34791442 chr2:46655169 T/C cg26688816 chr2:46740690 ATP6V1E2 -0.48 -6.99 -0.36 1.56e-11 HDL cholesterol; CRC trans rs4332037 0.722 rs4721140 chr7:1917635 A/T cg11693508 chr17:37793320 STARD3 0.57 7.07 0.36 9.28e-12 Bipolar disorder; CRC cis rs908922 0.676 rs533917 chr1:152518294 A/G cg23254163 chr1:152506842 NA 0.47 9.16 0.45 5.65e-18 Hair morphology; CRC cis rs8031584 0.958 rs11293 chr15:31234981 G/A cg14829155 chr15:31115871 NA -0.51 -8.2 -0.41 5.36e-15 Huntington's disease progression; CRC cis rs9858542 0.953 rs35261698 chr3:49537839 C/G cg03060546 chr3:49711283 APEH -0.47 -6.6 -0.34 1.63e-10 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs6831352 0.725 rs2602846 chr4:100025151 T/A cg13256891 chr4:100009986 ADH5 0.63 8.56 0.43 4.54e-16 Alcohol dependence; CRC cis rs477692 1.000 rs553371 chr10:131413676 T/C cg05714579 chr10:131428358 MGMT 0.53 7.81 0.4 7.95e-14 Response to temozolomide; CRC cis rs9811920 0.598 rs793470 chr3:99548274 C/T cg07805332 chr3:99536008 MIR548G;C3orf26 -0.45 -7.03 -0.36 1.2e-11 Axial length; CRC cis rs3096299 0.658 rs3934737 chr16:89560209 G/A cg00750074 chr16:89608354 SPG7 -0.51 -7.91 -0.4 4e-14 Multiple myeloma (IgH translocation); CRC cis rs9837602 0.810 rs35885423 chr3:99813218 C/G cg07805332 chr3:99536008 MIR548G;C3orf26 -0.47 -6.13 -0.32 2.57e-9 Breast cancer; CRC cis rs910316 1.000 rs8017642 chr14:75590822 G/A cg11812906 chr14:75593930 NEK9 0.59 9.25 0.45 2.97e-18 Height; CRC cis rs853679 0.517 rs9380058 chr6:28127444 T/C cg21251018 chr6:28226885 NKAPL 0.47 6.04 0.32 4.16e-9 Depression; CRC cis rs812925 0.519 rs1186696 chr2:61660483 A/C cg10580144 chr2:61372316 C2orf74 0.31 6.58 0.34 1.87e-10 Immature fraction of reticulocytes; CRC cis rs6460942 0.915 rs62447640 chr7:12488282 A/T cg06484146 chr7:12443880 VWDE -0.77 -7.99 -0.4 2.25e-14 Coronary artery disease; CRC cis rs1580019 0.563 rs4723169 chr7:32567577 G/A cg07520158 chr7:32535189 LSM5;AVL9 0.54 7.97 0.4 2.67e-14 Cognitive ability; CRC cis rs4253772 0.637 rs8135997 chr22:46651366 G/A cg03482458 chr22:46692211 CN5H6.4;GTSE1 0.48 6.36 0.33 6.94e-10 LDL cholesterol;Cholesterol, total; CRC cis rs6582630 0.555 rs7301250 chr12:38596244 G/T cg26384229 chr12:38710491 ALG10B 0.67 8.98 0.44 2.06e-17 Drug-induced liver injury (flucloxacillin); CRC cis rs911119 0.955 rs1011226 chr20:23605833 G/T cg16589663 chr20:23618590 CST3 -0.47 -6.84 -0.35 3.83e-11 Chronic kidney disease; CRC cis rs853679 0.517 rs9393895 chr6:28127621 T/C cg02683197 chr6:28174875 NA 0.84 10.31 0.49 8.48e-22 Depression; CRC cis rs2228479 0.557 rs11648881 chr16:89862434 T/C cg06558623 chr16:89946397 TCF25 1.19 11.69 0.54 1.18e-26 Skin colour saturation; CRC cis rs6564851 0.506 rs72831381 chr16:81258083 C/G cg05274606 chr16:81253692 PKD1L2 -0.35 -5.65 -0.3 3.53e-8 Carotenoid and tocopherol levels; CRC trans rs12829704 0.588 rs71446763 chr12:21418398 G/A cg22494081 chr2:11774142 GREB1 0.51 6.07 0.32 3.61e-9 Blood metabolite levels; CRC cis rs6952808 0.929 rs11768206 chr7:1932151 T/G cg21782813 chr7:2030301 MAD1L1 0.49 8.46 0.42 8.66e-16 Bipolar disorder and schizophrenia; CRC cis rs4665809 0.556 rs4665314 chr2:26415912 T/C cg26119090 chr2:26468346 HADHA;HADHB -1.05 -15.22 -0.64 5.61e-40 Gut microbiome composition (summer); CRC cis rs514406 0.729 rs534070 chr1:53308858 T/G cg24675658 chr1:53192096 ZYG11B -0.68 -10.21 -0.49 1.99e-21 Monocyte count; CRC cis rs4731207 0.724 rs4383910 chr7:124540841 A/C cg23710748 chr7:124431027 NA -0.37 -5.98 -0.31 5.75e-9 Cutaneous malignant melanoma; CRC trans rs1814175 0.534 rs1983448 chr11:49933856 C/A cg03929089 chr4:120376271 NA -0.92 -15.71 -0.65 6.66e-42 Height; CRC cis rs2294693 0.947 rs4714417 chr6:40987782 A/G cg14769373 chr6:40998127 UNC5CL -0.56 -7.52 -0.38 5.21e-13 Gastric cancer;Non-cardia gastric cancer; CRC cis rs9611565 0.559 rs132761 chr22:42004371 C/T cg06634786 chr22:41940651 POLR3H 0.64 6.9 0.36 2.68e-11 Vitiligo; CRC cis rs11696501 0.739 rs6104285 chr20:44295416 A/G cg11783356 chr20:44313418 WFDC10B -0.35 -5.61 -0.3 4.4e-8 Brain structure; CRC cis rs460214 0.564 rs464519 chr21:40024182 A/G cg05519781 chr21:40033154 ERG -0.44 -6.4 -0.33 5.2e-10 Response to cognitive-behavioural therapy in anxiety disorder; CRC cis rs9291683 0.609 rs12507050 chr4:10007305 G/T cg00071950 chr4:10020882 SLC2A9 0.67 12.75 0.58 1.53e-30 Bone mineral density; CRC cis rs801193 0.591 rs9986881 chr7:66173040 A/G cg18420555 chr7:66053803 NA 0.36 5.67 0.3 3.11e-8 Aortic root size; CRC cis rs2179367 0.959 rs504985 chr6:149658978 T/G cg07828024 chr6:149772892 ZC3H12D -0.37 -5.99 -0.31 5.48e-9 Dupuytren's disease; CRC cis rs2836950 0.565 rs7278297 chr21:40625752 A/C cg11644478 chr21:40555479 PSMG1 -0.44 -6.28 -0.33 1.05e-9 Menarche (age at onset); CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg21515243 chr18:21033072 RIOK3 -0.51 -6.38 -0.33 6.01e-10 Diisocyanate-induced asthma; CRC trans rs9747201 0.832 rs4072580 chr17:80160337 A/C cg07393940 chr7:158741817 NA 0.5 7.23 0.37 3.44e-12 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs9916302 0.904 rs11869109 chr17:37518205 G/T cg03013999 chr17:37608204 MED1 -0.47 -7.34 -0.38 1.7e-12 Glomerular filtration rate (creatinine); CRC cis rs1005277 0.557 rs176887 chr10:38406094 T/C cg25427524 chr10:38739819 LOC399744 -0.77 -13.65 -0.6 6.24e-34 Extrinsic epigenetic age acceleration; CRC cis rs3857536 0.813 rs9360190 chr6:66942302 T/C cg07460842 chr6:66804631 NA -0.43 -5.78 -0.3 1.72e-8 Blood trace element (Cu levels); CRC cis rs1865760 1.000 rs9348698 chr6:25929689 T/A cg17691542 chr6:26056736 HIST1H1C 0.54 8.0 0.4 2.16e-14 Height; CRC cis rs10504073 0.647 rs4493918 chr8:50015937 C/G cg00325661 chr8:49890786 NA 0.52 9.3 0.46 1.98e-18 Blood metabolite ratios; CRC cis rs2842992 0.915 rs2842980 chr6:160100116 A/T cg11366901 chr6:160182831 ACAT2 0.86 11.17 0.52 8.81e-25 Age-related macular degeneration (geographic atrophy); CRC cis rs780094 0.544 rs780110 chr2:27685388 G/A cg27432699 chr2:27873401 GPN1 -0.4 -6.01 -0.31 5.04e-9 Calcium levels;Fasting blood insulin;Metabolic traits;Triglyceride levels;Fasting plasma glucose;Urate levels in overweight individuals;Urate levels in obese individuals;Uric acid levels;Height;Age-related diseases, mortality and associated endophenotypes;Renal underexcretion gout;Fasting blood glucose (BMI interaction);Urate levels;Gondoic acid (20:1n-9) levels;Fasting blood insulin (BMI interaction);Triglycerides;Plasma omega-3 polyunsaturated fatty acid levels (docosapentaenoic acid);Type 2 diabetes;Nonalcoholic fatty liver disease;Hypertriglyceridemia;C-reactive protein;Age-related disease endophenotypes;LDL cholesterol;Metabolic syndrome;Crohn's disease;Alcohol consumption (drinks per week);Homeostasis model assessment of insulin resistance;Alcohol consumption;Red blood cell count;Fasting blood glucose; CRC cis rs909674 0.818 rs5757678 chr22:39843409 A/G cg11247378 chr22:39784982 NA 0.45 8.96 0.44 2.45e-17 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; CRC cis rs7914558 1.000 rs4917994 chr10:104811699 C/T cg04362960 chr10:104952993 NT5C2 0.6 9.04 0.45 1.38e-17 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC trans rs2228479 0.717 rs9282682 chr16:89805794 A/G cg24644049 chr4:85504048 CDS1 0.68 6.1 0.32 2.91e-9 Skin colour saturation; CRC trans rs6540559 0.546 rs57315825 chr1:210030197 C/T cg24434056 chr13:112550360 NA 0.36 6.18 0.32 1.92e-9 Cleft lip with or without cleft palate; CRC cis rs4713118 0.527 rs9461433 chr6:28095172 C/T cg15845792 chr6:28175446 NA 1.01 13.54 0.6 1.59e-33 Parkinson's disease; CRC cis rs7772486 0.790 rs4314514 chr6:146260010 A/G cg23711669 chr6:146136114 FBXO30 -0.71 -12.51 -0.57 1.25e-29 Lobe attachment (rater-scored or self-reported); CRC cis rs3771570 1.000 rs1984598 chr2:242284824 G/A cg21155796 chr2:242212141 HDLBP 0.57 6.78 0.35 5.61e-11 Prostate cancer; CRC cis rs4975709 0.589 rs931508 chr5:1861224 C/G cg12288994 chr5:1860383 NA 0.39 7.01 0.36 1.38e-11 Cardiovascular disease risk factors; CRC cis rs7552404 1.000 rs7513559 chr1:76173744 A/G cg22875332 chr1:76189707 ACADM 0.68 9.34 0.46 1.45e-18 Blood metabolite levels;Acylcarnitine levels; CRC cis rs6502050 0.799 rs7502524 chr17:80107261 C/T cg09264619 chr17:80180166 NA -0.34 -5.81 -0.3 1.5e-8 Life satisfaction; CRC cis rs7647973 0.621 rs3774800 chr3:49334768 A/G cg03060546 chr3:49711283 APEH -0.42 -6.02 -0.31 4.72e-9 Menarche (age at onset); CRC cis rs8180040 0.620 rs1811652 chr3:47208698 C/G cg02527881 chr3:46936655 PTH1R 0.35 6.09 0.32 3.07e-9 Colorectal cancer; CRC cis rs2949837 0.581 rs1543270 chr7:46006323 C/T cg15898840 chr7:45960834 IGFBP3 0.45 7.34 0.38 1.69e-12 Sitting height ratio; CRC cis rs13108904 0.905 rs11247983 chr4:1281951 C/G cg02018176 chr4:1364513 KIAA1530 0.47 7.65 0.39 2.25e-13 Obesity-related traits; CRC cis rs13108904 0.840 rs13106092 chr4:1257290 T/A cg20092199 chr4:1342459 KIAA1530 0.34 5.77 0.3 1.82e-8 Obesity-related traits; CRC cis rs66573146 0.634 rs56097119 chr4:7018692 C/G cg00086871 chr4:6988644 TBC1D14 0.96 7.53 0.38 4.89e-13 Granulocyte percentage of myeloid white cells; CRC cis rs10540 1.000 rs12418639 chr11:473300 A/C cg15790184 chr11:494944 RNH1 -0.57 -5.79 -0.3 1.62e-8 Body mass index; CRC cis rs6951245 0.938 rs113642700 chr7:1105654 C/T cg21664854 chr7:1097933 C7orf50;GPR146 0.78 8.89 0.44 4.25e-17 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs41271473 0.500 rs4606285 chr1:228887544 G/T cg00850481 chr1:228891306 NA -0.39 -5.97 -0.31 6.14e-9 Chronic lymphocytic leukemia; CRC cis rs2932538 0.883 rs6696991 chr1:113095661 C/T cg22162597 chr1:113214053 CAPZA1 0.59 8.65 0.43 2.3e-16 Systolic blood pressure;Diastolic blood pressure;Hypertension;Blood pressure; CRC cis rs1862618 0.853 rs832554 chr5:56115036 A/G cg03609598 chr5:56110824 MAP3K1 -0.85 -10.49 -0.5 2.05e-22 Initial pursuit acceleration; CRC trans rs1945213 0.694 rs11227113 chr11:55828024 C/T cg15704280 chr7:45808275 SEPT13 0.55 6.18 0.32 1.88e-9 Acute lymphoblastic leukemia (childhood); CRC cis rs9300255 0.602 rs884548 chr12:123634122 A/G cg00376283 chr12:123451042 ABCB9 0.61 8.42 0.42 1.18e-15 Neutrophil percentage of white cells; CRC cis rs17023223 0.537 rs56708249 chr1:119593205 C/G cg05756136 chr1:119680316 WARS2 -0.47 -6.3 -0.33 9.79e-10 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for BMI in active individuals; CRC trans rs9858542 0.953 rs6809216 chr3:49412559 G/A cg21659725 chr3:3221576 CRBN -0.65 -8.96 -0.44 2.56e-17 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs11098499 0.754 rs878376 chr4:120237702 G/A cg24375607 chr4:120327624 NA 0.47 7.53 0.38 4.91e-13 Corneal astigmatism; CRC cis rs4242434 0.927 rs11778693 chr8:22462852 T/C cg03733263 chr8:22462867 KIAA1967 1.04 20.1 0.74 3.54e-59 Exploratory eye movement dysfunction in schizophrenia (cognitive search score); CRC cis rs9733 0.519 rs10788792 chr1:150638572 T/G cg15448220 chr1:150897856 SETDB1 0.47 6.77 0.35 6.05e-11 Tonsillectomy; CRC cis rs4268898 0.931 rs34504814 chr2:24503766 C/T cg06627628 chr2:24431161 ITSN2 -0.58 -8.7 -0.43 1.65e-16 Asthma; CRC cis rs977987 0.843 rs11649638 chr16:75488285 G/A cg03315344 chr16:75512273 CHST6 0.54 9.2 0.45 4.34e-18 Dupuytren's disease; CRC cis rs4665809 0.556 rs4665314 chr2:26415912 T/C cg27170947 chr2:26402098 FAM59B -0.59 -7.65 -0.39 2.22e-13 Gut microbiome composition (summer); CRC cis rs9322193 0.576 rs7452592 chr6:150196581 A/G cg13206674 chr6:150067644 NUP43 0.59 7.03 0.36 1.23e-11 Lung cancer; CRC cis rs950776 0.518 rs56007453 chr15:78826239 T/C cg06917634 chr15:78832804 PSMA4 0.66 10.42 0.5 3.55e-22 Sudden cardiac arrest; CRC trans rs6951245 0.872 rs11768486 chr7:1101290 C/A cg13565492 chr6:43139072 SRF -0.72 -7.44 -0.38 8.63e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs875971 0.929 rs778682 chr7:65837934 A/G cg00343986 chr7:65444356 GUSB 0.43 6.3 0.33 9.66e-10 Aortic root size; CRC cis rs7811142 0.830 rs705866 chr7:99965285 T/C cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.14 15.11 0.64 1.53e-39 Platelet count; CRC cis rs66573146 1.000 rs6838250 chr4:6973184 C/G cg00086871 chr4:6988644 TBC1D14 0.96 7.32 0.37 1.96e-12 Granulocyte percentage of myeloid white cells; CRC cis rs1448094 0.967 rs10863118 chr12:86339232 C/G cg19622623 chr12:86230825 RASSF9 -0.36 -5.94 -0.31 7.17e-9 Major depressive disorder; CRC cis rs6582630 0.519 rs8189461 chr12:38374870 G/T cg13010199 chr12:38710504 ALG10B 0.47 6.3 0.33 9.3e-10 Drug-induced liver injury (flucloxacillin); CRC cis rs418053 0.624 rs4715451 chr6:13638984 A/G cg02206980 chr6:13574034 SIRT5 -0.37 -6.13 -0.32 2.53e-9 Breast cancer; CRC cis rs713587 0.967 rs713586 chr2:25158008 A/G cg22495460 chr2:25135724 ADCY3 -0.78 -14.12 -0.61 1.03e-35 Body mass index in non-asthmatics; CRC cis rs910873 0.505 rs6058099 chr20:33249134 C/T cg08999081 chr20:33150536 PIGU 0.49 5.91 0.31 8.58e-9 Melanoma; CRC cis rs10256972 0.568 rs1133043 chr7:1133305 C/G cg07092213 chr7:1199455 ZFAND2A -0.41 -5.79 -0.3 1.67e-8 Longevity;Endometriosis; CRC cis rs28386778 0.897 rs2727333 chr17:61876023 G/A cg11494091 chr17:61959527 GH2 0.59 10.03 0.48 7.61e-21 Prudent dietary pattern; CRC cis rs17767392 0.846 rs68073803 chr14:71757679 C/T cg13720639 chr14:72061746 SIPA1L1 -0.54 -6.87 -0.35 3.2e-11 Mitral valve prolapse; CRC cis rs1008375 0.966 rs10006317 chr4:17702525 A/G cg16339924 chr4:17578868 LAP3 0.49 6.3 0.33 9.78e-10 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs7927771 1.000 rs7120333 chr11:47817441 C/T cg18512352 chr11:47633146 NA -0.48 -9.4 -0.46 9.71e-19 Subjective well-being; CRC trans rs7726839 0.540 rs3749615 chr5:601485 C/T cg25482853 chr8:67687455 SGK3 1.11 13.07 0.58 9.87e-32 Obesity-related traits; CRC cis rs4700695 0.841 rs36303 chr5:65350374 A/G cg21114390 chr5:65439923 SFRS12 -0.67 -6.88 -0.35 3.01e-11 Facial morphology (factor 19); CRC cis rs3136516 0.772 rs7947747 chr11:46852839 A/G cg19486271 chr11:47235900 DDB2 -0.34 -5.64 -0.3 3.76e-8 Venous thromboembolism; CRC cis rs1150668 0.796 rs213236 chr6:28324397 T/C cg21251018 chr6:28226885 NKAPL 0.5 8.71 0.43 1.53e-16 Pubertal anthropometrics; CRC trans rs1728785 0.818 rs1728769 chr16:68564186 C/T cg04657470 chr2:198365150 HSPE1;HSPD1 0.57 6.78 0.35 5.72e-11 Ulcerative colitis; CRC cis rs863345 0.625 rs12075903 chr1:158458932 A/G cg12129480 chr1:158549410 OR10X1 -0.29 -6.07 -0.32 3.49e-9 Pneumococcal bacteremia; CRC cis rs9372498 0.536 rs7356947 chr6:118767920 A/G cg15382696 chr6:118971807 C6orf204 0.59 7.63 0.39 2.54e-13 Diastolic blood pressure; CRC cis rs4478858 0.735 rs4949384 chr1:31792141 A/G cg07478791 chr1:31886160 SERINC2 -0.41 -5.67 -0.3 3.13e-8 Alcohol dependence; CRC cis rs7552404 1.000 rs942270 chr1:76177332 G/A cg22875332 chr1:76189707 ACADM 0.68 9.09 0.45 9.75e-18 Blood metabolite levels;Acylcarnitine levels; CRC cis rs7089973 0.872 rs17092542 chr10:116630289 G/A cg23260525 chr10:116636907 FAM160B1 0.31 6.77 0.35 5.77e-11 Bipolar disorder or attention deficit hyperactivity disorder; CRC cis rs7192380 0.639 rs7186296 chr16:69808998 A/G cg00738113 chr16:70207722 CLEC18C 0.47 8.05 0.41 1.51e-14 Sjögren's syndrome; CRC cis rs12760731 0.565 rs57247289 chr1:178090138 G/A cg00404053 chr1:178313656 RASAL2 1.0 10.61 0.51 7.86e-23 Obesity-related traits; CRC cis rs2153535 0.584 rs9502723 chr6:8541504 G/A cg07606381 chr6:8435919 SLC35B3 0.69 11.29 0.53 3.23e-25 Motion sickness; CRC cis rs4664293 0.902 rs13391919 chr2:160560160 T/C cg08347373 chr2:160653686 CD302 -0.38 -6.21 -0.32 1.61e-9 Monocyte percentage of white cells; CRC cis rs9322193 0.632 rs3828700 chr6:150112169 C/G cg07701084 chr6:150067640 NUP43 0.48 6.69 0.35 9.5e-11 Lung cancer; CRC cis rs7914558 1.000 rs10748838 chr10:104943986 T/A cg04362960 chr10:104952993 NT5C2 0.59 8.59 0.43 3.53e-16 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC trans rs2727020 0.731 rs10450572 chr11:49281073 T/C cg03929089 chr4:120376271 NA 0.81 13.74 0.6 2.82e-34 Coronary artery disease; CRC cis rs7647973 0.580 rs2334958 chr3:49252364 C/T cg07636037 chr3:49044803 WDR6 0.81 12.53 0.57 1.04e-29 Menarche (age at onset); CRC trans rs2243480 0.808 rs12698508 chr7:65411958 A/T cg10756647 chr7:56101905 PSPH 0.71 7.57 0.39 3.91e-13 Diabetic kidney disease; CRC cis rs6674970 0.933 rs12134957 chr1:151045419 A/G cg11822372 chr1:151115635 SEMA6C 0.54 7.76 0.39 1.05e-13 Childhood ear infection; CRC cis rs9649213 0.593 rs2240349 chr7:97984663 C/T cg21770322 chr7:97807741 LMTK2 0.52 8.52 0.43 5.7e-16 Prostate cancer (SNP x SNP interaction); CRC cis rs6723226 0.699 rs376914 chr2:32508393 G/C cg02381751 chr2:32503542 YIPF4 0.57 8.28 0.42 3.21e-15 Intelligence (multi-trait analysis); CRC cis rs13064411 0.735 rs10511326 chr3:113216325 T/C cg18753928 chr3:113234510 CCDC52 -0.7 -10.83 -0.51 1.45e-23 Response to simvastatin treatment (PCSK9 protein level change); CRC cis rs12620999 0.878 rs59725626 chr2:237970010 G/A cg23555395 chr2:238036564 NA 0.52 8.09 0.41 1.19e-14 Systemic lupus erythematosus; CRC cis rs75804782 0.641 rs56134361 chr2:239318905 A/G cg18131467 chr2:239335373 ASB1 -0.7 -6.06 -0.32 3.71e-9 Morning vs. evening chronotype;Chronotype; CRC cis rs9381040 0.701 rs6933231 chr6:41163700 T/C cg03526776 chr6:41159608 TREML2 0.4 7.57 0.38 3.89e-13 Alzheimer's disease (late onset); CRC cis rs644799 1.000 rs473148 chr11:95628606 A/G cg03916912 chr11:95522834 CEP57;FAM76B 0.95 17.76 0.7 5.87e-50 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs174601 0.861 rs174584 chr11:61610750 G/A cg06781209 chr11:61594997 FADS2 -0.38 -5.81 -0.3 1.49e-8 Blood metabolite levels;Red blood cell fatty acid levels;Liver enzyme levels (alkaline phosphatase);Gondoic acid (20:1n-9) levels;Trans fatty acid levels; CRC cis rs4728302 0.869 rs6943986 chr7:133616965 G/A cg03336402 chr7:133662267 EXOC4 -0.47 -6.88 -0.35 3.05e-11 Intelligence;Intelligence (multi-trait analysis); CRC cis rs9486715 0.867 rs9384585 chr6:96875664 C/T cg06623918 chr6:96969491 KIAA0776 1.02 20.3 0.75 5.5e-60 Headache; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg03682117 chr10:116581829 FAM160B1 0.39 6.01 0.31 4.79e-9 Intelligence (multi-trait analysis); CRC cis rs995000 0.899 rs1168045 chr1:62982891 C/T cg19896129 chr1:63156450 NA -0.45 -7.02 -0.36 1.24e-11 Triglyceride levels; CRC cis rs11098499 0.909 rs9994810 chr4:120381590 A/G cg09307838 chr4:120376055 NA 0.71 11.02 0.52 3.08e-24 Corneal astigmatism; CRC cis rs12476592 0.571 rs196125 chr2:63859268 C/T cg10828910 chr2:63850056 LOC388955 0.49 6.19 0.32 1.76e-9 Childhood ear infection; CRC cis rs9323205 0.953 rs61144314 chr14:51620556 G/A cg23942311 chr14:51606299 NA -0.58 -7.13 -0.37 6.53e-12 Cancer; CRC cis rs561341 1.000 rs497479 chr17:30328605 C/T cg12193833 chr17:30244370 NA -0.73 -8.67 -0.43 2.07e-16 Hip circumference adjusted for BMI; CRC cis rs7772486 0.686 rs7744014 chr6:146123818 G/A cg13319975 chr6:146136371 FBXO30 -0.42 -6.27 -0.33 1.12e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs270601 0.913 rs273916 chr5:131659830 C/A cg11843238 chr5:131593191 PDLIM4 0.44 7.33 0.37 1.85e-12 Acylcarnitine levels; CRC cis rs1580019 0.587 rs10951338 chr7:32560089 A/G cg07520158 chr7:32535189 LSM5;AVL9 0.53 7.84 0.4 6.31e-14 Cognitive ability; CRC cis rs9300255 0.602 rs10744147 chr12:123643729 A/G cg00376283 chr12:123451042 ABCB9 0.56 6.93 0.36 2.18e-11 Neutrophil percentage of white cells; CRC cis rs67311347 1.000 rs56992941 chr3:40472434 A/T cg09455208 chr3:40491958 NA 0.44 8.94 0.44 2.84e-17 Renal cell carcinoma; CRC cis rs4664293 0.867 rs10194483 chr2:160596394 G/A cg08347373 chr2:160653686 CD302 -0.46 -7.36 -0.38 1.49e-12 Monocyte percentage of white cells; CRC cis rs12594515 1.000 rs7173144 chr15:45991196 A/G cg06207120 chr15:45996521 NA 0.31 7.56 0.38 4.02e-13 Waist circumference;Weight; CRC trans rs11098499 0.866 rs13125526 chr4:120288019 G/A cg25214090 chr10:38739885 LOC399744 0.61 9.66 0.47 1.39e-19 Corneal astigmatism; CRC cis rs6964587 1.000 rs6979085 chr7:91673623 C/T cg17063962 chr7:91808500 NA 0.79 13.8 0.61 1.67e-34 Breast cancer; CRC cis rs11252926 0.674 rs11598550 chr10:504778 A/C cg03684893 chr10:554711 DIP2C 0.35 5.73 0.3 2.33e-8 Psychosis in Alzheimer's disease; CRC trans rs4332037 0.707 rs4721096 chr7:1877311 T/C cg11693508 chr17:37793320 STARD3 -0.64 -7.93 -0.4 3.54e-14 Bipolar disorder; CRC cis rs10504073 0.669 rs55948643 chr8:50026403 C/G cg00325661 chr8:49890786 NA 0.44 7.83 0.4 6.69e-14 Blood metabolite ratios; CRC cis rs908922 0.584 rs71626721 chr1:152532745 A/G cg23254163 chr1:152506842 NA 0.45 8.99 0.44 2e-17 Hair morphology; CRC cis rs3785574 0.962 rs7215915 chr17:61828385 C/T cg06873352 chr17:61820015 STRADA 0.49 7.95 0.4 2.96e-14 Height; CRC cis rs1832871 0.711 rs7770047 chr6:158685696 A/G cg07165851 chr6:158734300 TULP4 0.61 7.72 0.39 1.41e-13 Height; CRC cis rs447 0.806 rs2372033 chr7:83746313 C/T cg22846510 chr7:83753280 SEMA3A -0.42 -5.71 -0.3 2.52e-8 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs9488822 0.676 rs12196579 chr6:116351724 G/T cg26893134 chr6:116381904 FRK 0.28 8.26 0.41 3.58e-15 Cholesterol, total;LDL cholesterol; CRC cis rs2836974 1.000 rs2836974 chr21:40663181 A/G cg11644478 chr21:40555479 PSMG1 -0.79 -11.78 -0.54 5.72e-27 Cognitive function; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg15527401 chr19:59071099 UBE2M;LOC100131691 0.52 6.89 0.36 2.93e-11 Thyroid stimulating hormone; CRC trans rs10982213 0.830 rs2274163 chr9:117188714 C/T cg20713816 chr5:89705801 CETN3 0.36 5.97 0.31 6.12e-9 Interleukin-6 levels; CRC cis rs6860806 0.507 rs272868 chr5:131680751 C/G cg18301423 chr5:131593218 PDLIM4 0.38 6.39 0.33 5.63e-10 Breast cancer; CRC cis rs12893668 0.572 rs34000399 chr14:104101417 T/C cg24130564 chr14:104152367 KLC1 -0.42 -5.63 -0.3 3.93e-8 Reticulocyte count; CRC cis rs447735 0.587 rs258335 chr16:89720944 G/A cg03605463 chr16:89740564 NA 0.48 7.73 0.39 1.34e-13 Hemoglobin concentration; CRC cis rs6662572 0.737 rs4660315 chr1:46270942 G/C cg08644498 chr1:46502608 NA -0.44 -7.0 -0.36 1.4e-11 Blood protein levels; CRC cis rs782590 0.774 rs782637 chr2:55894247 T/C cg18811423 chr2:55921094 PNPT1 0.83 15.58 0.65 2.3e-41 Metabolic syndrome; CRC cis rs832540 0.931 rs1466008 chr5:56213406 G/C cg18230493 chr5:56204884 C5orf35 -0.39 -5.76 -0.3 1.91e-8 Coronary artery disease; CRC cis rs28735056 0.967 rs623546 chr18:77595228 C/T cg20368463 chr18:77673604 PQLC1 -0.55 -8.32 -0.42 2.31e-15 Schizophrenia; CRC cis rs12477438 0.765 rs12468807 chr2:99691994 C/A cg14399236 chr2:99771627 LIPT1;TSGA10 -0.74 -10.35 -0.5 6.51e-22 Chronic sinus infection; CRC cis rs6952808 0.582 rs10479762 chr7:2045351 T/C cg04267008 chr7:1944627 MAD1L1 0.6 8.83 0.44 6.53e-17 Bipolar disorder and schizophrenia; CRC cis rs1008375 0.932 rs6449315 chr4:17590219 A/G cg16339924 chr4:17578868 LAP3 0.69 8.97 0.44 2.22e-17 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs2033711 0.840 rs4801590 chr19:58961813 G/C cg00825309 chr19:58991885 ZNF446 -0.48 -6.89 -0.36 2.77e-11 Uric acid clearance; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg15191848 chr19:59084942 MZF1;LOC100131691 0.44 6.07 0.32 3.57e-9 Anxiety disorder; CRC trans rs2898857 0.504 rs7214496 chr17:47384611 C/G cg11430096 chr6:110968061 CDK19 0.53 7.97 0.4 2.64e-14 Cancer; CRC cis rs12995491 0.731 rs34991383 chr2:88500337 T/G cg24977027 chr2:88469347 THNSL2 -0.33 -5.6 -0.3 4.52e-8 Response to metformin (IC50); CRC cis rs28830936 0.510 rs12440605 chr15:42102285 A/G cg17847044 chr15:42102381 MAPKBP1 0.38 9.18 0.45 4.96e-18 Diastolic blood pressure; CRC cis rs9902453 0.757 rs12453308 chr17:28441604 C/T cg26525008 chr17:28256777 EFCAB5;SSH2 0.57 8.59 0.43 3.56e-16 Coffee consumption (cups per day); CRC cis rs7249142 0.506 rs8101388 chr19:19293938 A/C cg08207377 chr19:19281140 LOC729991-MEF2B;MEF2B -0.39 -6.12 -0.32 2.63e-9 IgG glycosylation; CRC cis rs147649347 1 rs147649347 chr2:24210076 GATAA/G cg08917208 chr2:24149416 ATAD2B 1.01 10.1 0.49 4.47e-21 Reticulocyte count;Reticulocyte fraction of red cells;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; CRC cis rs10791323 0.559 rs10750549 chr11:133730820 A/G cg03690763 chr11:133734501 NA -0.39 -6.4 -0.33 5.25e-10 Childhood ear infection; CRC cis rs13191362 0.573 rs1877769 chr6:163252315 A/G cg06582575 chr6:163149167 PACRG;PARK2 0.52 7.19 0.37 4.29e-12 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg17470723 chr8:74884337 TCEB1 0.41 6.76 0.35 6.32e-11 Liver disease severity in Alagille syndrome; CRC cis rs4481887 0.893 rs6702113 chr1:248486151 T/C cg13385794 chr1:248469461 NA 0.4 7.1 0.36 7.96e-12 Common traits (Other); CRC cis rs6604026 0.698 rs4847384 chr1:93382279 T/C cg17283838 chr1:93427260 FAM69A -0.49 -6.75 -0.35 6.54e-11 Multiple sclerosis; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg04232466 chr8:21988724 HR 0.52 6.89 0.36 2.93e-11 Thyroid stimulating hormone; CRC cis rs262150 0.644 rs2730228 chr7:158789361 T/C cg07130601 chr7:158766826 NA 0.42 6.0 0.31 5.26e-9 Facial morphology (factor 20); CRC cis rs9916302 0.752 rs6503513 chr17:37561613 A/G cg20243544 chr17:37824526 PNMT -0.43 -5.66 -0.3 3.28e-8 Glomerular filtration rate (creatinine); CRC cis rs12188164 0.965 rs11744539 chr5:451425 C/T cg26850624 chr5:429559 AHRR -0.81 -13.82 -0.61 1.41e-34 Cystic fibrosis severity; CRC cis rs6951245 0.554 rs76243429 chr7:1152543 C/T cg21664854 chr7:1097933 C7orf50;GPR146 0.56 6.97 0.36 1.69e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs10751667 0.666 rs12295141 chr11:947065 G/A ch.11.42038R chr11:967971 AP2A2 0.57 9.73 0.47 7.65e-20 Alzheimer's disease (late onset); CRC cis rs6696846 0.936 rs6662930 chr1:205041465 T/C cg00857998 chr1:205179979 DSTYK 0.43 5.78 0.3 1.7e-8 Red blood cell count; CRC cis rs877282 0.945 rs11253398 chr10:790012 T/C cg17470449 chr10:769945 NA 0.68 9.03 0.45 1.48e-17 Uric acid levels; CRC cis rs10751667 1.000 rs10794357 chr11:973374 T/C ch.11.42038R chr11:967971 AP2A2 0.69 11.35 0.53 2.04e-25 Alzheimer's disease (late onset); CRC cis rs8141529 0.732 rs6005872 chr22:29172898 T/G cg15103426 chr22:29168792 CCDC117 0.61 8.91 0.44 3.63e-17 Lymphocyte counts; CRC trans rs12940923 1.000 rs11867412 chr17:56382512 C/T cg16900910 chr15:72789182 ARIH1 0.55 6.2 0.32 1.73e-9 Circulating myeloperoxidase levels (plasma); CRC cis rs13336428 0.730 rs28653458 chr16:1525850 T/C cg04976154 chr16:1532411 NA -0.42 -8.26 -0.41 3.61e-15 Bone mineral density; CRC cis rs875971 0.522 rs1880556 chr7:65432544 T/C cg05627663 chr7:65219948 SNORA22;CCT6P1 0.46 6.94 0.36 2.12e-11 Aortic root size; CRC cis rs1005277 0.579 rs2474608 chr10:38457109 C/T cg25427524 chr10:38739819 LOC399744 -0.76 -13.39 -0.59 6.42e-33 Extrinsic epigenetic age acceleration; CRC cis rs1401999 1.000 rs7620350 chr3:183710053 A/T cg20387954 chr3:183756860 HTR3D 0.45 7.64 0.39 2.47e-13 Anterior chamber depth; CRC cis rs6684514 0.961 rs68170055 chr1:156332331 C/G cg16558208 chr1:156270281 VHLL 0.54 8.16 0.41 7.09e-15 Mean corpuscular hemoglobin concentration;Glycated hemoglobin levels; CRC cis rs4862750 0.872 rs6553029 chr4:187876470 G/T cg03647317 chr4:187891568 NA 0.52 9.67 0.47 1.21e-19 Lobe attachment (rater-scored or self-reported); CRC cis rs9322193 0.567 rs7742692 chr6:150213499 A/G cg07701084 chr6:150067640 NUP43 0.48 6.98 0.36 1.6e-11 Lung cancer; CRC cis rs2797160 1.000 rs1739375 chr6:126012013 T/C cg05901451 chr6:126070800 HEY2 0.39 6.03 0.32 4.5e-9 Endometrial cancer; CRC cis rs1728785 1.000 rs698728 chr16:68625253 T/C cg02972257 chr16:68554789 NA -0.56 -6.99 -0.36 1.51e-11 Ulcerative colitis; CRC cis rs10504229 0.775 rs17216236 chr8:58159352 G/A cg11062466 chr8:58055876 NA 0.45 6.02 0.31 4.73e-9 Developmental language disorder (linguistic errors); CRC cis rs2075371 1.000 rs1862047 chr7:133978078 G/C cg11752832 chr7:134001865 SLC35B4 0.48 7.44 0.38 8.72e-13 Mean platelet volume; CRC cis rs2032447 0.933 rs1540275 chr6:26036476 T/C cg12310025 chr6:25882481 NA -0.52 -7.23 -0.37 3.31e-12 Intelligence (multi-trait analysis); CRC cis rs270601 0.721 rs270621 chr5:131605821 C/A cg04518342 chr5:131593106 PDLIM4 0.53 8.93 0.44 3.14e-17 Acylcarnitine levels; CRC cis rs13108904 0.901 rs13112706 chr4:1303682 G/T cg00684032 chr4:1343700 KIAA1530 0.44 6.38 0.33 6.11e-10 Obesity-related traits; CRC cis rs2836974 0.965 rs6517538 chr21:40656242 C/T cg11644478 chr21:40555479 PSMG1 0.81 12.32 0.56 6.05e-29 Cognitive function; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg16239906 chr20:35724590 RBL1 0.42 6.25 0.33 1.24e-9 Intelligence (multi-trait analysis); CRC cis rs7727544 0.606 rs11950562 chr5:131652529 A/C cg12564285 chr5:131593104 PDLIM4 0.35 6.32 0.33 8.3e-10 Blood metabolite levels; CRC cis rs7666738 0.581 rs34205844 chr4:98887494 C/A cg05340658 chr4:99064831 C4orf37 0.57 8.53 0.43 5.38e-16 Colonoscopy-negative controls vs population controls; CRC cis rs875971 0.964 rs11765965 chr7:65842221 A/G cg18876405 chr7:65276391 NA 0.52 9.04 0.45 1.37e-17 Aortic root size; CRC trans rs10982213 0.830 rs2274163 chr9:117188714 C/T cg11480627 chr11:70672876 SHANK2 0.31 6.3 0.33 9.27e-10 Interleukin-6 levels; CRC cis rs9487051 0.768 rs371960 chr6:109525082 A/G cg21918786 chr6:109611834 NA -0.35 -6.04 -0.32 4.19e-9 Reticulocyte fraction of red cells; CRC cis rs4072980 0.545 rs7528185 chr1:38452059 C/T cg04673462 chr1:38461896 NA -0.38 -5.84 -0.31 1.27e-8 Coronary artery disease; CRC cis rs7726839 0.574 rs12522955 chr5:639231 C/A cg16447950 chr5:562315 NA -0.75 -9.78 -0.47 5.49e-20 Obesity-related traits; CRC cis rs7113874 0.569 rs7131358 chr11:8558333 G/C cg20771178 chr11:8615675 STK33 -0.35 -5.86 -0.31 1.12e-8 Body mass index in physically active individuals;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs10791323 0.627 rs2723614 chr11:133705871 T/G cg03690763 chr11:133734501 NA -0.35 -5.8 -0.3 1.59e-8 Childhood ear infection; CRC trans rs931812 0.825 rs6993937 chr8:101898707 A/G cg20993868 chr7:22813445 NA 0.5 9.28 0.46 2.31e-18 Attention deficit hyperactivity disorder and conduct disorder; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg14782929 chr1:204544645 NA -0.4 -6.1 -0.32 2.98e-9 Liver disease severity in Alagille syndrome; CRC cis rs10089 1.000 rs13356473 chr5:127478250 T/G cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.73 10.13 0.49 3.54e-21 Ileal carcinoids; CRC cis rs9826463 0.582 rs55687115 chr3:142148372 G/A cg20824294 chr3:142316082 PLS1 0.38 6.05 0.32 3.87e-9 QRS duration in Tripanosoma cruzi seropositivity; CRC cis rs478304 0.654 rs1074156 chr11:65458169 G/T cg27068330 chr11:65405492 SIPA1 -0.65 -9.5 -0.46 4.63e-19 Acne (severe); CRC cis rs17253792 0.822 rs13379342 chr14:56050452 A/G cg24579896 chr14:56047964 C14orf33;KTN1 0.71 6.06 0.32 3.77e-9 Putamen volume; CRC cis rs9462846 0.845 rs9471959 chr6:42884517 A/G cg21280719 chr6:42927975 GNMT -0.33 -6.21 -0.32 1.57e-9 Blood protein levels; CRC cis rs9768139 0.708 rs11771764 chr7:158119871 A/G cg24154853 chr7:158122151 PTPRN2 0.63 10.26 0.49 1.3e-21 Calcium levels; CRC cis rs17401966 0.898 rs11587495 chr1:10448999 T/C cg19773385 chr1:10388646 KIF1B -0.68 -10.93 -0.52 6.28e-24 Hepatocellular carcinoma; CRC cis rs13108904 0.935 rs2293633 chr4:1291640 T/C cg19318889 chr4:1322082 MAEA 0.44 6.77 0.35 5.92e-11 Obesity-related traits; CRC cis rs9393692 0.645 rs766406 chr6:26319588 G/T cg13736514 chr6:26305472 NA -0.69 -11.81 -0.55 4.47e-27 Educational attainment; CRC cis rs654950 0.901 rs594656 chr1:41999873 C/T cg06885757 chr1:42089581 HIVEP3 -0.49 -7.89 -0.4 4.55e-14 Airway imaging phenotypes; CRC cis rs34172651 0.517 rs11642954 chr16:24824248 G/A cg04756594 chr16:24857601 SLC5A11 0.32 6.58 0.34 1.89e-10 Intelligence (multi-trait analysis); CRC cis rs7209700 0.600 rs7218632 chr17:45365153 A/G cg08085267 chr17:45401833 C17orf57 0.44 6.32 0.33 8.29e-10 IgG glycosylation; CRC cis rs28386778 0.897 rs2584642 chr17:61942427 T/C cg11494091 chr17:61959527 GH2 0.59 9.95 0.48 1.45e-20 Prudent dietary pattern; CRC cis rs9788682 0.894 rs4461039 chr15:78817447 A/T cg06917634 chr15:78832804 PSMA4 0.44 5.68 0.3 2.93e-8 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; CRC cis rs6912958 0.781 rs7757636 chr6:88256092 T/G cg08069147 chr6:88032118 GJB7;C6orf162 -0.57 -8.47 -0.42 8.37e-16 Monocyte percentage of white cells; CRC cis rs17376456 0.757 rs6859757 chr5:93206042 C/T cg21475434 chr5:93447410 FAM172A 0.78 7.13 0.37 6.35e-12 Diabetic retinopathy; CRC cis rs4423214 0.802 rs4616066 chr11:71183846 G/A cg05163923 chr11:71159392 DHCR7 -0.63 -7.61 -0.39 2.92e-13 Vitamin D levels; CRC cis rs6541297 0.878 rs4846905 chr1:230279582 C/T cg20703242 chr1:230279135 GALNT2 -0.48 -6.94 -0.36 2.14e-11 Coronary artery disease; CRC cis rs4862750 0.957 rs6858853 chr4:187903412 A/C cg03452623 chr4:187889614 NA 0.94 22.28 0.78 1.13e-67 Lobe attachment (rater-scored or self-reported); CRC cis rs3771570 0.901 rs3771585 chr2:242400723 G/A cg21155796 chr2:242212141 HDLBP 0.57 6.66 0.34 1.17e-10 Prostate cancer; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg18597434 chr13:76055871 TBC1D4 0.49 7.05 0.36 1.09e-11 Response to antipsychotic treatment; CRC cis rs11212617 1.000 rs228590 chr11:108096141 A/G cg12106634 chr11:108092400 ATM;NPAT 0.43 6.39 0.33 5.57e-10 Response to metformin in type 2 diabetes (glycemic); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg08997445 chr19:57947026 ZNF749 0.39 6.08 0.32 3.37e-9 Liver disease severity in Alagille syndrome; CRC cis rs17162190 0.659 rs12024530 chr1:26812298 G/A cg17456097 chr1:26900765 RPS6KA1 0.44 6.07 0.32 3.45e-9 Mean corpuscular volume; CRC cis rs7659604 0.702 rs61217486 chr4:122693973 T/C cg06713675 chr4:122721982 EXOSC9 -0.54 -8.68 -0.43 1.89e-16 Type 2 diabetes; CRC trans rs9291683 0.517 rs11736479 chr4:10017387 G/C cg26043149 chr18:55253948 FECH 0.51 7.91 0.4 3.95e-14 Bone mineral density; CRC cis rs11764590 0.813 rs11768212 chr7:1992582 A/C cg21155852 chr7:2048760 MAD1L1 -0.47 -6.51 -0.34 2.83e-10 Neuroticism; CRC cis rs9611565 0.592 rs8779 chr22:42070276 T/C cg03806693 chr22:41940476 POLR3H 1.05 13.07 0.58 1.02e-31 Vitiligo; CRC cis rs4713118 0.869 rs9295743 chr6:27715102 G/C cg26587870 chr6:27730563 NA -0.43 -6.71 -0.35 8.63e-11 Parkinson's disease; CRC cis rs4523957 0.890 rs9908888 chr17:2102453 G/C cg16513277 chr17:2031491 SMG6 -0.52 -8.7 -0.43 1.61e-16 Autism spectrum disorder or schizophrenia;Schizophrenia; CRC cis rs7552404 0.655 rs1146646 chr1:76265500 G/A cg22875332 chr1:76189707 ACADM 0.6 8.45 0.42 9.42e-16 Blood metabolite levels;Acylcarnitine levels; CRC cis rs10782582 0.609 rs2029680 chr1:76363505 A/C cg10523679 chr1:76189770 ACADM -0.41 -5.87 -0.31 1.06e-8 Daytime sleep phenotypes; CRC trans rs853679 1.000 rs1679732 chr6:28221264 G/A cg06606381 chr12:133084897 FBRSL1 0.62 6.21 0.32 1.63e-9 Depression; CRC cis rs736801 0.569 rs11748193 chr5:131725329 A/T cg02033258 chr5:131593261 PDLIM4 0.35 6.17 0.32 2.06e-9 Breast cancer;Mosquito bite size; CRC cis rs736408 0.609 rs1029871 chr3:52797634 G/C cg18099408 chr3:52552593 STAB1 -0.44 -7.16 -0.37 5.28e-12 Bipolar disorder; CRC cis rs7772486 0.719 rs7753770 chr6:146066161 G/A cg23711669 chr6:146136114 FBXO30 -0.74 -12.63 -0.57 4.3e-30 Lobe attachment (rater-scored or self-reported); CRC cis rs2153535 0.580 rs1119689 chr6:8460754 C/G cg07606381 chr6:8435919 SLC35B3 0.68 10.89 0.51 8.73e-24 Motion sickness; CRC cis rs3617 0.573 rs2336668 chr3:52919096 G/T cg11645453 chr3:52864694 ITIH4 -0.37 -7.09 -0.36 8.19e-12 Red blood cell count;Autism spectrum disorder or schizophrenia; CRC trans rs61931739 0.534 rs10844816 chr12:34248533 C/A cg26384229 chr12:38710491 ALG10B 0.52 6.6 0.34 1.65e-10 Morning vs. evening chronotype; CRC cis rs4820539 1.000 rs3827316 chr22:23468538 T/C cg14186256 chr22:23484241 RTDR1 0.91 18.01 0.7 6.06e-51 Bone mineral density; CRC cis rs9287719 0.674 rs12620209 chr2:10720441 T/C cg00105475 chr2:10696890 NA 0.45 7.06 0.36 9.97e-12 Prostate cancer; CRC cis rs597539 0.654 rs619727 chr11:68627535 A/G cg21963583 chr11:68658836 MRPL21 0.61 11.2 0.53 6.72e-25 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs6912958 0.535 rs448580 chr6:88040399 A/C cg04972856 chr6:88032051 C6orf162;GJB7 0.36 6.81 0.35 4.75e-11 Monocyte percentage of white cells; CRC cis rs6908034 0.607 rs112659166 chr6:19807409 C/T cg02682789 chr6:19804855 NA 0.79 6.79 0.35 5.11e-11 Endometriosis;Deep ovarian and/or rectovaginal disease with dense adhesions; CRC cis rs4718428 0.705 rs4718430 chr7:66432024 G/T cg18252515 chr7:66147081 NA -0.52 -6.96 -0.36 1.87e-11 Corneal structure; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg03884976 chr16:577621 SOLH;C16orf10 0.4 5.99 0.31 5.38e-9 Intelligence (multi-trait analysis); CRC cis rs6582630 0.502 rs4559747 chr12:38436235 G/A cg26384229 chr12:38710491 ALG10B 0.67 9.52 0.46 3.9e-19 Drug-induced liver injury (flucloxacillin); CRC cis rs8014204 0.604 rs11159109 chr14:75389074 G/A cg08847533 chr14:75593920 NEK9 0.48 6.8 0.35 4.89e-11 Caffeine consumption; CRC cis rs372883 0.506 rs2832300 chr21:30749315 A/G cg24692254 chr21:30365293 RNF160 0.54 8.44 0.42 1.03e-15 Pancreatic cancer; CRC cis rs644799 1.000 rs557079 chr11:95530125 C/G cg25478527 chr11:95522999 CEP57;FAM76B 0.51 7.69 0.39 1.7e-13 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs2153535 0.580 rs5001324 chr6:8451604 A/T cg07606381 chr6:8435919 SLC35B3 0.68 10.85 0.51 1.2e-23 Motion sickness; CRC cis rs60843830 1.000 rs56321614 chr2:268191 G/T cg00108164 chr2:264199 ACP1;SH3YL1 0.61 9.72 0.47 8.59e-20 Spherical equivalent (joint analysis main effects and education interaction); CRC cis rs10971721 0.822 rs10971792 chr9:33920953 A/G cg13495928 chr9:33750294 PRSS3 0.56 5.97 0.31 6.15e-9 Body mass index; CRC cis rs875971 0.545 rs2420612 chr7:66001812 G/A cg03233332 chr7:66118400 NA -0.41 -5.65 -0.3 3.52e-8 Aortic root size; CRC cis rs17767392 0.918 rs34725136 chr14:71760422 C/T cg13720639 chr14:72061746 SIPA1L1 -0.53 -6.86 -0.35 3.45e-11 Mitral valve prolapse; CRC cis rs4713118 0.513 rs149942 chr6:28001610 T/C cg25164649 chr6:28176230 NA 0.61 8.98 0.44 2.21e-17 Parkinson's disease; CRC cis rs210143 1 rs210143 chr6:33546930 T/C cg24505687 chr6:33548425 BAK1 0.4 6.74 0.35 6.98e-11 Neutrophil percentage of granulocytes;B-cell malignancies (chronic lymphocytic leukemia, Hodgkin lymphoma or multiple myeloma) (pleiotropy);Chronic lymphocytic leukemia; CRC cis rs4132462 0.821 rs7422793 chr2:212603778 T/C cg15635483 chr2:212618994 ERBB4 -0.39 -6.12 -0.32 2.73e-9 Intelligence (multi-trait analysis); CRC trans rs7395662 0.591 rs10838968 chr11:48595046 A/G cg21153622 chr11:89784906 NA -0.52 -8.71 -0.43 1.46e-16 HDL cholesterol; CRC cis rs4588572 0.688 rs11743511 chr5:77692819 C/T cg11446398 chr5:77624930 NA 0.44 6.43 0.33 4.5e-10 Triglycerides; CRC trans rs7615952 0.512 rs2979351 chr3:125363599 C/T cg08546805 chr12:8549446 NA -0.44 -6.62 -0.34 1.48e-10 Blood pressure (smoking interaction); CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg01153979 chr6:79577195 IRAK1BP1 0.45 7.18 0.37 4.56e-12 Obesity-related traits; CRC cis rs713587 0.520 rs487617 chr2:25309756 C/G cg22495460 chr2:25135724 ADCY3 0.44 6.5 0.34 3.04e-10 Body mass index in non-asthmatics; CRC cis rs17270561 1.000 rs79867288 chr6:25828416 A/G cg17691542 chr6:26056736 HIST1H1C 0.84 9.52 0.46 3.83e-19 Iron status biomarkers; CRC cis rs9747201 0.926 rs7222764 chr17:80062698 G/A cg14673194 chr17:80132900 CCDC57 0.48 6.19 0.32 1.82e-9 Peripheral arterial disease (traffic-related air pollution interaction); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg08037420 chr3:172428855 NCEH1 0.48 6.73 0.35 7.35e-11 Response to antipsychotic treatment; CRC cis rs4972806 0.814 rs6710370 chr2:177045969 T/C cg13092806 chr2:177043255 NA 0.81 13.22 0.59 2.65e-32 IgG glycosylation; CRC cis rs936229 0.798 rs1869959 chr15:75147332 A/C cg14664628 chr15:75095509 CSK -0.9 -16.49 -0.67 6.23e-45 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); CRC cis rs2019137 0.868 rs6755639 chr2:113981810 A/G cg12889195 chr2:113992843 PAX8;LOC440839;LOC654433 0.5 7.29 0.37 2.33e-12 Lymphocyte counts; CRC cis rs9291683 0.588 rs3796829 chr4:10019138 C/G cg00071950 chr4:10020882 SLC2A9 0.68 13.33 0.59 1.07e-32 Bone mineral density; CRC cis rs7249142 0.573 rs2238668 chr19:19282597 A/G cg08207377 chr19:19281140 LOC729991-MEF2B;MEF2B -0.38 -6.18 -0.32 1.92e-9 IgG glycosylation; CRC cis rs250677 0.652 rs250675 chr5:148438565 A/C cg18129178 chr5:148520854 ABLIM3 0.37 5.8 0.3 1.56e-8 Breast cancer; CRC cis rs12580194 0.593 rs55637917 chr12:55747565 T/C cg19537932 chr12:55886519 OR6C68 -0.71 -9.1 -0.45 8.8e-18 Cancer; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg02326858 chr1:151253959 ZNF687 0.52 7.4 0.38 1.16e-12 Response to antipsychotic treatment; CRC cis rs9291683 0.588 rs35438220 chr4:9999398 C/T cg00071950 chr4:10020882 SLC2A9 0.64 11.98 0.55 1.09e-27 Bone mineral density; CRC trans rs3780486 0.801 rs10971424 chr9:33138775 T/C cg20290983 chr6:43655470 MRPS18A 1.18 27.1 0.83 7.82e-86 IgG glycosylation; CRC cis rs2032447 0.765 rs6942072 chr6:26014987 A/G cg12588279 chr6:26043732 HIST1H2BB 0.46 6.86 0.35 3.51e-11 Intelligence (multi-trait analysis); CRC trans rs916888 0.773 rs199457 chr17:44795469 C/T cg07870213 chr5:140052090 DND1 1.0 11.15 0.52 1.04e-24 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs2243480 1.000 rs6958289 chr7:65657111 T/G cg25985355 chr7:65971099 NA 0.54 6.13 0.32 2.57e-9 Diabetic kidney disease; CRC cis rs801193 0.548 rs2659891 chr7:66201114 A/G cg11764359 chr7:65958608 NA 0.59 8.86 0.44 5.04e-17 Aortic root size; CRC cis rs11122272 0.735 rs2790886 chr1:231529491 A/C cg06096015 chr1:231504339 EGLN1 0.41 6.18 0.32 1.91e-9 Hemoglobin concentration; CRC cis rs8177179 0.967 rs4078166 chr3:133435979 C/A cg24879335 chr3:133465180 TF 0.48 9.32 0.46 1.76e-18 Iron status biomarkers (transferrin levels); CRC cis rs8141797 1.000 rs8141797 chr22:24582041 C/T cg20894457 chr22:24584366 SUSD2 -0.62 -7.95 -0.4 3.09e-14 Amyotrophic lateral sclerosis;Coronary artery disease; CRC trans rs703108 0.731 rs7898954 chr10:22323646 A/G cg05592406 chr12:118542027 VSIG10 -0.55 -6.47 -0.34 3.49e-10 Monocyte percentage of white cells; CRC cis rs2153535 0.580 rs9505454 chr6:8478532 T/G cg07606381 chr6:8435919 SLC35B3 0.67 10.78 0.51 2.07e-23 Motion sickness; CRC trans rs7726839 0.540 rs72703083 chr5:595365 C/T cg11887960 chr12:57824829 NA 0.59 6.66 0.34 1.15e-10 Obesity-related traits; CRC cis rs7552404 0.731 rs10873808 chr1:76406767 T/C cg10523679 chr1:76189770 ACADM 0.69 8.18 0.41 6.3e-15 Blood metabolite levels;Acylcarnitine levels; CRC cis rs11785693 0.862 rs73183618 chr8:4988340 T/C cg26367366 chr8:4980734 NA 0.79 9.75 0.47 6.64e-20 Neuroticism (multi-trait analysis);Neuroticism; CRC cis rs10982256 0.870 rs1408525 chr9:117274994 C/T cg13636371 chr9:117264095 DFNB31 0.37 7.2 0.37 4.2e-12 Bipolar disorder; CRC cis rs10992471 0.528 rs10820975 chr9:95211922 T/G cg14631576 chr9:95140430 CENPP -0.31 -5.63 -0.3 3.78e-8 Visceral adipose tissue/subcutaneous adipose tissue ratio; CRC cis rs853679 0.546 rs200990 chr6:27815823 T/G cg26587870 chr6:27730563 NA -0.66 -6.81 -0.35 4.63e-11 Depression; CRC cis rs10876993 0.928 rs1689594 chr12:58057156 T/C cg18357645 chr12:58087776 OS9 0.57 8.1 0.41 1.1e-14 Celiac disease or Rheumatoid arthritis; CRC cis rs10504229 0.683 rs11786043 chr8:58133174 T/C cg22535103 chr8:58192502 C8orf71 -0.7 -9.34 -0.46 1.47e-18 Developmental language disorder (linguistic errors); CRC cis rs7408868 1.000 rs2074618 chr19:15276143 C/T cg14696996 chr19:15285081 NOTCH3 0.97 8.99 0.44 1.99e-17 Pulse pressure; CRC cis rs11758351 0.715 rs75390741 chr6:26209784 A/T cg22723502 chr6:26240528 HIST1H4F -0.37 -6.09 -0.32 3.11e-9 Gout;Renal underexcretion gout; CRC trans rs61931739 0.517 rs4104182 chr12:34081343 G/A cg26384229 chr12:38710491 ALG10B 0.54 7.01 0.36 1.34e-11 Morning vs. evening chronotype; CRC cis rs7246657 1.000 rs10426297 chr19:37798373 A/G cg23950597 chr19:37808831 NA -0.51 -6.11 -0.32 2.86e-9 Coronary artery calcification; CRC cis rs6964587 0.934 rs12531561 chr7:91707780 A/G cg17063962 chr7:91808500 NA 0.77 13.4 0.59 5.64e-33 Breast cancer; CRC cis rs1577917 0.682 rs6909767 chr6:86228109 G/A cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A 0.57 8.02 0.4 1.89e-14 Response to antipsychotic treatment; CRC cis rs9611565 0.765 rs132906 chr22:41799767 G/C cg06634786 chr22:41940651 POLR3H 0.44 5.62 0.3 4.02e-8 Vitiligo; CRC cis rs9329289 0.603 rs2458698 chr10:2548452 C/T cg05625103 chr10:2543513 NA 0.47 7.42 0.38 9.83e-13 Age-related hearing impairment; CRC cis rs4555082 0.718 rs2816619 chr14:105732551 G/C cg13114125 chr14:105738426 BRF1 -0.84 -12.2 -0.56 1.64e-28 Mean platelet volume;Platelet distribution width; CRC cis rs2239547 0.562 rs2581810 chr3:52960859 C/T cg11645453 chr3:52864694 ITIH4 -0.52 -9.8 -0.48 4.57e-20 Schizophrenia; CRC cis rs6665290 0.669 rs6426558 chr1:227175367 G/T cg10327440 chr1:227177885 CDC42BPA -0.95 -18.72 -0.72 9.67e-54 Myeloid white cell count; CRC cis rs17092148 0.887 rs6120684 chr20:33179788 A/G cg08999081 chr20:33150536 PIGU 0.49 6.25 0.33 1.29e-9 Neuroticism; CRC cis rs4665809 1.000 rs6709595 chr2:26259885 A/G cg25036284 chr2:26402008 FAM59B -0.44 -5.86 -0.31 1.15e-8 Gut microbiome composition (summer); CRC cis rs6952808 0.656 rs11764212 chr7:2067593 C/A cg20295408 chr7:1910781 MAD1L1 -0.43 -5.84 -0.31 1.26e-8 Bipolar disorder and schizophrenia; CRC cis rs9549260 0.816 rs7324090 chr13:41253958 A/T cg21288729 chr13:41239152 FOXO1 0.48 7.31 0.37 2e-12 Red blood cell count; CRC cis rs10504229 0.683 rs6984765 chr8:58127124 T/C cg05313129 chr8:58192883 C8orf71 -0.43 -6.11 -0.32 2.74e-9 Developmental language disorder (linguistic errors); CRC cis rs2836974 0.568 rs4816620 chr21:40613786 A/G cg06238570 chr21:40685208 BRWD1 -0.8 -12.78 -0.58 1.16e-30 Cognitive function; CRC cis rs34172651 0.876 rs2112785 chr16:24781176 C/T cg00339695 chr16:24857497 SLC5A11 0.27 6.39 0.33 5.57e-10 Intelligence (multi-trait analysis); CRC cis rs736801 0.569 rs12517950 chr5:131731326 A/G cg12564285 chr5:131593104 PDLIM4 0.34 5.93 0.31 7.53e-9 Breast cancer;Mosquito bite size; CRC cis rs73206853 0.614 rs117546059 chr12:110508632 T/C cg12870014 chr12:110450643 ANKRD13A 0.79 7.19 0.37 4.39e-12 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC cis rs17155006 0.746 rs420753 chr7:107746253 A/G cg05962710 chr7:107745446 LAMB4 -0.41 -7.44 -0.38 8.61e-13 Pneumococcal bacteremia; CRC cis rs1152591 0.624 rs1266927 chr14:64651663 C/A cg23250157 chr14:64679961 SYNE2 0.43 6.37 0.33 6.52e-10 Atrial fibrillation; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg04452770 chr12:53267981 NA 0.46 6.32 0.33 8.48e-10 Response to antipsychotic treatment; CRC cis rs738322 1.000 rs133009 chr22:38569653 G/C cg25457927 chr22:38595422 NA -0.36 -7.47 -0.38 7.23e-13 Cutaneous nevi; CRC cis rs483180 0.512 rs597308 chr1:120214953 G/A cg19096424 chr1:120255104 PHGDH 0.45 6.48 0.34 3.27e-10 Macular telangiectasia type 2; CRC cis rs1322512 1.000 rs1727052 chr6:152947175 T/C cg03415253 chr6:152958462 SYNE1 -0.41 -6.37 -0.33 6.5e-10 Tonometry; CRC cis rs4654899 0.931 rs10799671 chr1:21196764 C/T cg02927042 chr1:21476669 EIF4G3 0.4 6.39 0.33 5.67e-10 Superior frontal gyrus grey matter volume; CRC cis rs780096 0.526 rs1647266 chr2:27693485 T/C cg22903471 chr2:27725779 GCKR -0.37 -6.06 -0.32 3.65e-9 Total body bone mineral density; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg04662714 chr4:68567018 LOC550112;UBA6 0.45 6.16 0.32 2.1e-9 Response to antipsychotic treatment; CRC cis rs2637266 0.600 rs12770441 chr10:78384983 C/T cg18941641 chr10:78392320 NA -0.37 -6.39 -0.33 5.52e-10 Pulmonary function; CRC cis rs3858526 0.883 rs1453429 chr11:5933478 C/T cg02574844 chr11:5959923 NA -0.42 -5.86 -0.31 1.12e-8 DNA methylation (variation); CRC trans rs1814175 0.645 rs10128731 chr11:50023554 G/T cg03929089 chr4:120376271 NA -0.89 -15.93 -0.66 9.4e-43 Height; CRC cis rs4563143 0.675 rs73029042 chr19:29267979 A/T cg14983838 chr19:29218262 NA 0.46 6.76 0.35 6.47e-11 Methadone dose in opioid dependence; CRC cis rs7666738 0.962 rs2865991 chr4:99067369 C/A cg05340658 chr4:99064831 C4orf37 0.53 7.43 0.38 9.24e-13 Colonoscopy-negative controls vs population controls; CRC cis rs1113500 0.933 rs10785833 chr1:108639082 A/G cg06207961 chr1:108661230 NA 0.39 5.75 0.3 2.07e-8 Growth-regulated protein alpha levels; CRC cis rs739401 0.611 rs494427 chr11:3048140 A/G cg05729581 chr11:3078854 CARS -0.57 -8.33 -0.42 2.23e-15 Longevity; CRC cis rs7605827 0.897 rs7425203 chr2:15697410 A/G cg19274914 chr2:15703543 NA 0.39 5.8 0.3 1.57e-8 Educational attainment (years of education); CRC cis rs3820068 0.655 rs72645826 chr1:15889741 A/G cg27534772 chr1:16042836 PLEKHM2 0.45 7.5 0.38 6.07e-13 Systolic blood pressure; CRC cis rs73206853 0.764 rs76044375 chr12:110901339 C/T cg12870014 chr12:110450643 ANKRD13A 0.74 7.9 0.4 4.21e-14 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC cis rs780096 0.526 rs4582 chr2:27604279 A/G cg27432699 chr2:27873401 GPN1 -0.5 -7.53 -0.38 4.78e-13 Total body bone mineral density; CRC cis rs514406 0.683 rs10157120 chr1:53210888 A/G cg25767906 chr1:53392781 SCP2 -0.42 -6.65 -0.34 1.24e-10 Monocyte count; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg15555402 chr12:19593456 AEBP2 -0.38 -6.07 -0.32 3.6e-9 Myopia (pathological); CRC cis rs1971762 0.545 rs10747675 chr12:54000031 A/G cg06632207 chr12:54070931 ATP5G2 -0.36 -6.02 -0.32 4.61e-9 Height; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg04226401 chr1:100818170 CDC14A 0.41 6.0 0.31 5.26e-9 Intelligence (multi-trait analysis); CRC cis rs2455601 0.671 rs2568091 chr11:8986048 C/A cg09997546 chr11:8931473 C11orf17;ST5 -0.43 -5.92 -0.31 7.89e-9 Schizophrenia; CRC cis rs172166 0.516 rs2791333 chr6:28111114 A/G cg12172441 chr6:28176163 NA 0.45 6.57 0.34 1.97e-10 Cardiac Troponin-T levels; CRC cis rs7677751 0.806 rs7673984 chr4:55088761 C/T cg00691999 chr4:55094011 PDGFRA 0.43 6.02 0.31 4.77e-9 Corneal astigmatism; CRC cis rs801193 0.527 rs2707837 chr7:66181073 G/C cg18252515 chr7:66147081 NA -0.42 -5.98 -0.31 5.83e-9 Aortic root size; CRC cis rs875971 0.545 rs313828 chr7:65552614 T/C cg03233332 chr7:66118400 NA 0.45 6.2 0.32 1.69e-9 Aortic root size; CRC cis rs67311347 1.000 rs6762997 chr3:40478151 C/T cg24209194 chr3:40518798 ZNF619 0.44 6.79 0.35 5.32e-11 Renal cell carcinoma; CRC cis rs2455601 1.000 rs12418190 chr11:8899818 G/C cg09997546 chr11:8931473 C11orf17;ST5 -0.51 -6.26 -0.33 1.2e-9 Schizophrenia; CRC cis rs7589728 0.563 rs2292868 chr2:88475047 A/G cg24977027 chr2:88469347 THNSL2 -0.6 -7.23 -0.37 3.51e-12 Plasma clusterin levels; CRC cis rs1915919 0.794 rs4398451 chr3:20010886 T/C cg05072819 chr3:20081367 KAT2B 0.47 6.82 0.35 4.36e-11 Post-traumatic stress disorder; CRC cis rs12325245 0.536 rs35432891 chr16:58561966 G/A cg19824325 chr16:58548873 SETD6 0.91 6.09 0.32 3.08e-9 Schizophrenia; CRC cis rs11809207 0.574 rs2783633 chr1:26505265 A/G cg24519413 chr1:26490540 NA 0.37 6.26 0.33 1.23e-9 Height; CRC cis rs8060686 0.641 rs2107369 chr16:68116018 A/C cg08314208 chr16:67682810 RLTPR -0.52 -6.22 -0.32 1.54e-9 HDL cholesterol;Metabolic syndrome; CRC cis rs2952156 0.920 rs2517958 chr17:37838751 G/A cg20243544 chr17:37824526 PNMT 0.56 8.97 0.44 2.35e-17 Asthma; CRC cis rs7707921 1.000 rs891159 chr5:81491087 A/G cg17942617 chr5:81327376 ATG10 0.4 6.03 0.32 4.49e-9 Breast cancer; CRC cis rs13256369 1.000 rs12550762 chr8:8576535 T/A cg00074818 chr8:8560427 CLDN23 0.35 6.52 0.34 2.57e-10 Obesity-related traits; CRC cis rs7591163 1.000 rs7591163 chr2:228715375 C/T cg14329157 chr2:228736135 WDR69 -0.48 -6.59 -0.34 1.77e-10 Blood pressure; CRC cis rs1223397 0.651 rs453877 chr6:13297463 G/T cg07912922 chr6:13274314 PHACTR1 0.37 5.74 0.3 2.16e-8 Blood pressure; CRC cis rs3764400 0.508 rs72823519 chr17:46061885 G/T cg10706073 chr17:46328419 SKAP1 -0.65 -6.33 -0.33 7.99e-10 Body mass index; CRC cis rs4664308 1.000 rs17831191 chr2:160911332 T/C cg03641300 chr2:160917029 PLA2R1 -0.75 -12.51 -0.57 1.18e-29 Idiopathic membranous nephropathy; CRC trans rs1908814 0.516 rs11996277 chr8:11800031 G/A cg08975724 chr8:8085496 FLJ10661 0.41 6.07 0.32 3.47e-9 Neuroticism; CRC trans rs1814175 0.591 rs11040589 chr11:49862449 A/G cg15704280 chr7:45808275 SEPT13 -0.94 -16.65 -0.68 1.36e-45 Height; CRC trans rs6500957 0.920 rs17648524 chr16:7459683 C/G cg07491357 chr18:9914943 VAPA 0.44 6.41 0.33 5.13e-10 Spherical equivalent (joint analysis main effects and education interaction); CRC cis rs11645898 0.935 rs8047881 chr16:72193906 A/G cg14768367 chr16:72042858 DHODH -0.55 -6.32 -0.33 8.6e-10 Blood protein levels; CRC trans rs10983614 1.000 rs7867776 chr9:120072627 A/G cg02352945 chr3:38496316 LOC100128640;ACVR2B 0.44 6.11 0.32 2.79e-9 Survival in pancreatic cancer; CRC cis rs883565 0.568 rs4381879 chr3:39028460 G/C cg01426195 chr3:39028469 NA -0.52 -8.31 -0.42 2.49e-15 Handedness; CRC cis rs2072499 1.000 rs2241107 chr1:156182710 C/T cg25208724 chr1:156163844 SLC25A44 -1.07 -25.04 -0.81 3.5e-78 Testicular germ cell tumor; CRC cis rs13191362 0.935 rs34587258 chr6:162945580 T/C cg21926612 chr6:163149169 PACRG;PARK2 0.79 9.52 0.46 3.98e-19 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs425277 0.606 rs262663 chr1:2084598 T/C cg24578937 chr1:2090814 PRKCZ 0.39 7.08 0.36 8.81e-12 Height; CRC cis rs921968 0.541 rs647990 chr2:219441428 T/C cg02176678 chr2:219576539 TTLL4 0.53 8.43 0.42 1.08e-15 Mean corpuscular hemoglobin concentration; CRC cis rs4664308 0.870 rs55959207 chr2:161016981 A/C cg03641300 chr2:160917029 PLA2R1 -0.73 -12.13 -0.56 3.02e-28 Idiopathic membranous nephropathy; CRC cis rs7259376 0.875 rs6511345 chr19:22537436 T/C cg02657401 chr19:22469223 NA -0.33 -7.27 -0.37 2.63e-12 Menopause (age at onset); CRC cis rs4665809 1.000 rs10048648 chr2:26320315 T/C cg25036284 chr2:26402008 FAM59B -0.45 -5.98 -0.31 5.89e-9 Gut microbiome composition (summer); CRC cis rs7618915 0.501 rs3774366 chr3:52641255 T/C cg08222913 chr3:52553049 STAB1 -0.34 -6.34 -0.33 7.69e-10 Bipolar disorder; CRC cis rs3736485 0.966 rs7161973 chr15:51854163 T/C cg08986416 chr15:51914746 DMXL2 -0.45 -6.56 -0.34 2.04e-10 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs9325144 0.555 rs7968322 chr12:38792348 T/C cg26384229 chr12:38710491 ALG10B -0.51 -7.47 -0.38 7.19e-13 Morning vs. evening chronotype; CRC cis rs6921919 0.697 rs758398 chr6:28320674 C/T cg21251018 chr6:28226885 NKAPL 0.49 7.75 0.39 1.18e-13 Autism spectrum disorder or schizophrenia; CRC cis rs6540559 0.611 rs926347 chr1:209965193 T/C cg22029157 chr1:209979665 IRF6 0.72 9.47 0.46 5.57e-19 Cleft lip with or without cleft palate; CRC cis rs7647973 0.516 rs4308307 chr3:49193216 C/T cg20833759 chr3:49053208 WDR6;DALRD3 0.37 6.12 0.32 2.67e-9 Menarche (age at onset); CRC cis rs10540 0.730 rs61876338 chr11:493730 A/G cg19913688 chr11:428466 ANO9 -0.7 -7.21 -0.37 3.76e-12 Body mass index; CRC cis rs4148883 0.629 rs10009145 chr4:100047929 G/A cg12011299 chr4:100065546 ADH4 0.53 11.74 0.54 8.27e-27 Alcohol dependence; CRC cis rs10791097 0.694 rs1054869 chr11:130742630 G/A cg12179176 chr11:130786555 SNX19 0.75 12.66 0.57 3.28e-30 Autism spectrum disorder or schizophrenia;Schizophrenia; CRC cis rs12586317 0.547 rs28395170 chr14:35506988 C/T cg16230307 chr14:35515116 FAM177A1 0.85 10.2 0.49 2.04e-21 Psoriasis; CRC cis rs34330 0.562 rs7486387 chr12:12866911 G/A cg04607235 chr12:12878440 APOLD1 -0.71 -7.35 -0.38 1.54e-12 Systemic lupus erythematosus; CRC cis rs2404602 0.716 rs8039545 chr15:76707247 A/G cg22467129 chr15:76604101 ETFA -0.43 -7.22 -0.37 3.53e-12 Blood metabolite levels; CRC cis rs17767392 0.794 rs17767362 chr14:71733790 G/A cg13720639 chr14:72061746 SIPA1L1 -0.53 -6.46 -0.34 3.78e-10 Mitral valve prolapse; CRC cis rs6088813 0.925 rs1540928 chr20:33961845 C/A cg14752227 chr20:34000481 UQCC -0.36 -5.62 -0.3 3.99e-8 Height; CRC cis rs7927771 1.000 rs10838757 chr11:47763016 T/C cg20307385 chr11:47447363 PSMC3 -0.49 -6.51 -0.34 2.81e-10 Subjective well-being; CRC cis rs4728302 0.905 rs7459333 chr7:133628701 G/A cg03336402 chr7:133662267 EXOC4 0.41 5.95 0.31 6.85e-9 Intelligence;Intelligence (multi-trait analysis); CRC cis rs4363385 0.818 rs10788854 chr1:153002320 C/T cg25856811 chr1:152973957 SPRR3 -0.25 -6.79 -0.35 5.23e-11 Inflammatory skin disease; CRC cis rs7833790 0.963 rs6473312 chr8:82732515 C/A cg17211192 chr8:82754475 SNX16 -0.54 -6.65 -0.34 1.21e-10 Diastolic blood pressure; CRC cis rs600626 0.578 rs11821808 chr11:75451187 C/T cg24262691 chr11:75473276 NA 0.53 7.76 0.39 1.05e-13 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CRC cis rs28386778 0.863 rs9207 chr17:61823899 C/T cg23090583 chr17:61904693 PSMC5;FTSJ3 1.04 20.57 0.75 5.01e-61 Prudent dietary pattern; CRC cis rs796364 0.806 rs56216998 chr2:200944333 G/T cg25936922 chr2:200820526 C2orf60;C2orf47 -0.68 -6.52 -0.34 2.58e-10 Schizophrenia; CRC cis rs1697139 1.000 rs1697139 chr5:66511535 A/G cg11553311 chr5:66541588 NA 0.45 7.52 0.38 5.12e-13 Breast cancer; CRC cis rs8031584 0.706 rs2177670 chr15:31157751 G/T cg14829155 chr15:31115871 NA -0.66 -10.21 -0.49 1.9e-21 Huntington's disease progression; CRC cis rs10911232 0.507 rs4129857 chr1:183004547 C/T ch.1.3577855R chr1:183094577 LAMC1 0.86 14.9 0.63 1.01e-38 Hypertriglyceridemia; CRC trans rs2303319 0.504 rs12470743 chr2:162611202 G/A cg22988483 chr14:93581567 ITPK1 -0.66 -6.07 -0.32 3.52e-9 Cognitive function; CRC cis rs7584330 0.554 rs3751109 chr2:238427194 T/C cg14458575 chr2:238380390 NA 0.46 6.53 0.34 2.47e-10 Prostate cancer; CRC trans rs9903692 0.954 rs875065 chr17:46139569 C/T cg13910583 chr8:56987998 RPS20 -0.44 -5.99 -0.31 5.63e-9 Pulse pressure; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg03022368 chr16:83986702 OSGIN1 0.44 6.12 0.32 2.72e-9 Intelligence (multi-trait analysis); CRC cis rs4321325 0.733 rs75834205 chr2:127947237 G/T cg11380483 chr2:127933992 NA 0.62 7.02 0.36 1.25e-11 Protein C levels; CRC cis rs651907 0.535 rs13094753 chr3:101525082 A/G cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.59 7.86 0.4 5.42e-14 Colorectal cancer; CRC cis rs77633900 0.614 rs2469242 chr15:76876710 A/G cg21673338 chr15:77095150 SCAPER -0.72 -7.25 -0.37 3.09e-12 Non-glioblastoma glioma;Glioma; CRC cis rs910316 0.763 rs2080201 chr14:75629972 C/T cg08847533 chr14:75593920 NEK9 -0.84 -14.54 -0.63 2.42e-37 Height; CRC cis rs17270561 0.608 rs4711102 chr6:25742075 T/C cg16482183 chr6:26056742 HIST1H1C 0.83 10.69 0.51 4.46e-23 Iron status biomarkers; CRC cis rs1950626 0.662 rs72700538 chr14:101441911 C/G cg02351406 chr14:101447389 SNORD114-20;SNORD114-21 0.96 15.65 0.65 1.23e-41 Pelvic organ prolapse (moderate/severe); CRC cis rs6952808 0.929 rs2280550 chr7:1976556 G/A cg04267008 chr7:1944627 MAD1L1 -0.76 -10.51 -0.5 1.87e-22 Bipolar disorder and schizophrenia; CRC cis rs13144136 0.687 rs11723092 chr4:10651891 G/A cg10242279 chr4:10666415 CLNK -0.37 -6.43 -0.33 4.58e-10 Resistance to antihypertensive treatment in hypertension; CRC trans rs8005745 0.505 rs710047 chr14:62118819 C/G cg23087241 chr11:134123413 THYN1;ACAD8 -0.44 -6.07 -0.32 3.47e-9 Select biomarker traits; CRC cis rs9372498 0.536 rs17080292 chr6:118850266 A/G cg01339444 chr6:118972232 C6orf204 0.53 5.99 0.31 5.48e-9 Diastolic blood pressure; CRC cis rs12188164 0.714 rs11741954 chr5:421455 G/T cg17553881 chr5:443987 EXOC3;C5orf55 -0.37 -7.52 -0.38 5.35e-13 Cystic fibrosis severity; CRC trans rs3733585 0.673 rs6849729 chr4:9958732 T/C cg26043149 chr18:55253948 FECH -0.5 -7.62 -0.39 2.81e-13 Cleft plate (environmental tobacco smoke interaction); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg07923305 chr1:46598507 PIK3R3 0.47 6.69 0.35 9.63e-11 Response to antipsychotic treatment; CRC cis rs4974559 0.739 rs6599298 chr4:1298122 A/G cg02980000 chr4:1222292 CTBP1 0.71 7.95 0.4 2.95e-14 Systolic blood pressure; CRC cis rs9916302 0.821 rs12938268 chr17:37572139 G/A cg03013999 chr17:37608204 MED1 0.45 6.74 0.35 7.08e-11 Glomerular filtration rate (creatinine); CRC cis rs12101261 0.536 rs2371463 chr14:81457788 G/A cg06600135 chr14:81408086 NA 0.39 5.68 0.3 2.94e-8 Graves' disease; CRC cis rs6502050 0.799 rs58538819 chr17:80107153 G/C cg22110888 chr17:80059540 CCDC57 0.43 6.65 0.34 1.26e-10 Life satisfaction; CRC cis rs9303401 0.646 rs8067682 chr17:57219391 A/G cg10487724 chr17:56770010 TEX14;RAD51C 0.42 6.4 0.33 5.35e-10 Cognitive test performance; CRC cis rs7945705 0.837 rs10769966 chr11:8847041 C/A cg00186954 chr11:8933980 ST5;C11orf17 0.38 6.09 0.32 3.13e-9 Hemoglobin concentration; CRC cis rs853679 0.517 rs9468298 chr6:28122345 A/G cg25164649 chr6:28176230 NA 0.78 9.66 0.47 1.33e-19 Depression; CRC cis rs6752107 0.503 rs12997325 chr2:234237387 A/G cg07618928 chr2:234183455 ATG16L1;SCARNA5 0.49 7.42 0.38 9.86e-13 Crohn's disease;Inflammatory bowel disease; CRC cis rs735396 0.627 rs2264778 chr12:121450354 C/A cg25281562 chr12:121454272 C12orf43 0.44 6.16 0.32 2.1e-9 N-glycan levels; CRC cis rs4660306 0.961 rs7546268 chr1:45965340 T/C cg03123370 chr1:45965343 CCDC163P;MMACHC -0.56 -7.96 -0.4 2.9e-14 Homocysteine levels; CRC cis rs755249 0.567 rs16826000 chr1:39713860 G/T cg18385671 chr1:39797026 MACF1 -0.42 -5.99 -0.31 5.5e-9 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs7044106 0.791 rs4836829 chr9:123482747 C/T cg09586646 chr9:123605570 PSMD5;LOC253039 0.68 9.85 0.48 3.04e-20 Hip circumference adjusted for BMI; CRC cis rs4665809 0.590 rs1122972 chr2:26418788 A/C cg08067268 chr2:26466485 HADHB;HADHA -0.66 -8.45 -0.42 9.58e-16 Gut microbiome composition (summer); CRC cis rs7811142 0.830 rs6955367 chr7:99961194 A/G cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.83 11.44 0.53 1e-25 Platelet count; CRC cis rs12594515 1.000 rs6493167 chr15:45986809 G/A cg19682013 chr15:45996608 NA 0.33 6.78 0.35 5.7e-11 Waist circumference;Weight; CRC cis rs7949030 0.591 rs12049914 chr11:62369436 C/G cg13298116 chr11:62369859 EML3;MTA2 0.61 10.71 0.51 3.81e-23 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; CRC cis rs7811142 1.000 rs2897358 chr7:100088640 C/G cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.93 12.31 0.56 6.45e-29 Platelet count; CRC cis rs13256369 0.901 rs12681327 chr8:8566414 G/T cg06671706 chr8:8559999 CLDN23 0.59 8.38 0.42 1.59e-15 Obesity-related traits; CRC cis rs7618915 0.547 rs62255371 chr3:52747321 A/G cg07507251 chr3:52567010 NT5DC2 0.4 5.75 0.3 2.04e-8 Bipolar disorder; CRC cis rs55883249 1.000 rs75139639 chr2:9763905 A/T cg23886495 chr2:9695866 ADAM17 0.5 5.75 0.3 2.03e-8 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg10169971 chr6:83902988 RWDD2A;PGM3 -0.42 -6.63 -0.34 1.37e-10 Myopia (pathological); CRC cis rs853679 0.517 rs9468298 chr6:28122345 A/G cg21251018 chr6:28226885 NKAPL 0.48 6.17 0.32 2.02e-9 Depression; CRC cis rs78456975 0.527 rs10203194 chr2:1558021 A/G cg26248373 chr2:1572462 NA -0.8 -11.01 -0.52 3.36e-24 Placebo response in major depressive disorder (% change in symptom score); CRC cis rs728616 0.614 rs61859191 chr10:82091027 T/C cg11900509 chr10:81946545 ANXA11 -0.54 -6.11 -0.32 2.86e-9 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs9611519 0.580 rs8138349 chr22:41412723 C/T cg03806693 chr22:41940476 POLR3H -0.41 -5.75 -0.3 2.02e-8 Neuroticism; CRC cis rs4319547 0.760 rs61954973 chr12:123074168 T/C cg05707623 chr12:122985044 ZCCHC8 -0.75 -9.4 -0.46 9.56e-19 Body mass index; CRC cis rs7662987 0.517 rs2602858 chr4:100030461 T/C cg13256891 chr4:100009986 ADH5 0.63 8.56 0.43 4.54e-16 Smoking initiation; CRC cis rs17539620 0.534 rs11541339 chr6:154831643 G/C cg20019720 chr6:154832845 CNKSR3 0.56 11.05 0.52 2.33e-24 Lipoprotein (a) levels; CRC cis rs208520 0.779 rs208446 chr6:66903515 T/C cg07460842 chr6:66804631 NA -0.92 -11.51 -0.54 5.56e-26 Exhaled nitric oxide output; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg09755102 chr1:33283495 S100PBP;YARS 0.45 6.29 0.33 1.04e-9 Response to antipsychotic treatment; CRC cis rs7811142 1.000 rs2406253 chr7:100077273 A/G cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.6 7.7 0.39 1.62e-13 Platelet count; CRC trans rs11722228 1.000 rs4697695 chr4:9915850 C/T cg26043149 chr18:55253948 FECH 0.7 10.28 0.49 1.15e-21 Gout;Urate levels;Serum uric acid levels; CRC cis rs2050392 0.517 rs602966 chr10:30755853 C/T cg25182066 chr10:30743637 MAP3K8 -0.51 -7.05 -0.36 1.08e-11 Inflammatory bowel disease; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg15585372 chr7:97910571 BRI3 0.47 6.88 0.35 3.09e-11 Response to antipsychotic treatment; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg00012992 chr14:61788345 PRKCH 0.39 6.55 0.34 2.27e-10 Liver disease severity in Alagille syndrome; CRC cis rs4889855 0.614 rs7209676 chr17:78500751 T/C cg16591659 chr17:78472290 NA -0.64 -7.79 -0.39 8.62e-14 Fractional excretion of uric acid; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg25656237 chr2:98703423 VWA3B 0.45 6.48 0.34 3.44e-10 Response to antipsychotic treatment; CRC cis rs12325245 0.536 rs71389028 chr16:58663260 G/A cg01472538 chr16:58549086 SETD6 1.12 7.38 0.38 1.28e-12 Schizophrenia; CRC cis rs72781680 0.611 rs56113233 chr2:24341085 A/C cg06627628 chr2:24431161 ITSN2 -0.54 -6.33 -0.33 8.08e-10 Lymphocyte counts; CRC cis rs12541635 0.739 rs10955412 chr8:107075592 T/C cg10147462 chr8:107024639 NA -0.54 -9.19 -0.45 4.4e-18 Age of smoking initiation; CRC cis rs5753618 0.561 rs5753543 chr22:31685458 G/A cg22777020 chr22:31556080 RNF185 -0.52 -5.9 -0.31 8.86e-9 Colorectal cancer; CRC cis rs1023500 0.573 rs6002592 chr22:42476754 A/C cg25452165 chr22:42524984 CYP2D6 -0.41 -6.12 -0.32 2.63e-9 Schizophrenia; CRC cis rs1862618 0.853 rs252916 chr5:56121788 G/C cg24531977 chr5:56204891 C5orf35 -0.78 -10.78 -0.51 2.15e-23 Initial pursuit acceleration; CRC cis rs2991971 0.967 rs2356551 chr1:46009318 C/T cg15605315 chr1:45957053 TESK2 0.42 6.77 0.35 6.08e-11 High light scatter reticulocyte count; CRC cis rs6500395 1.000 rs9936004 chr16:48566088 A/G cg04672837 chr16:48644449 N4BP1 0.45 6.49 0.34 3.2e-10 Response to tocilizumab in rheumatoid arthritis; CRC cis rs10504229 0.639 rs67002486 chr8:58117218 A/G cg24829409 chr8:58192753 C8orf71 -0.55 -8.03 -0.4 1.71e-14 Developmental language disorder (linguistic errors); CRC cis rs7615952 0.641 rs12487875 chr3:125787224 C/A cg05084668 chr3:125655381 ALG1L -0.45 -6.53 -0.34 2.55e-10 Blood pressure (smoking interaction); CRC cis rs7412746 0.658 rs7521719 chr1:150913134 G/A cg18016565 chr1:150552671 MCL1 0.42 6.05 0.32 3.98e-9 Melanoma; CRC cis rs910316 0.503 rs12894709 chr14:75441734 G/A cg03030879 chr14:75389066 RPS6KL1 -0.44 -6.82 -0.35 4.49e-11 Height; CRC cis rs7043114 0.525 rs1053446 chr9:95146761 T/A cg14631576 chr9:95140430 CENPP -0.31 -5.9 -0.31 8.88e-9 Height; CRC cis rs10782582 0.609 rs2029680 chr1:76363505 A/C cg03433033 chr1:76189801 ACADM -0.42 -6.0 -0.31 5.09e-9 Daytime sleep phenotypes; CRC cis rs514406 0.548 rs6670871 chr1:53212082 A/C cg08859206 chr1:53392774 SCP2 0.41 6.37 0.33 6.38e-10 Monocyte count; CRC cis rs763121 0.853 rs5757226 chr22:39070550 T/C cg06544989 chr22:39130855 UNC84B 0.45 6.9 0.36 2.7e-11 Menopause (age at onset); CRC cis rs7193541 0.965 rs7199068 chr16:74698263 C/G cg01733217 chr16:74700730 RFWD3 0.85 15.79 0.66 3.45e-42 Multiple myeloma; CRC cis rs7264396 0.690 rs2425172 chr20:34443893 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.6 -10.19 -0.49 2.18e-21 Total cholesterol levels; CRC cis rs7680126 0.626 rs11721501 chr4:10189135 G/A cg00071950 chr4:10020882 SLC2A9 -0.54 -6.72 -0.35 7.9e-11 Urate levels in lean individuals;Urate levels in overweight individuals;Urate levels in obese individuals; CRC cis rs2179367 0.959 rs9390677 chr6:149710497 T/C cg11245181 chr6:149772854 ZC3H12D -0.41 -6.15 -0.32 2.25e-9 Dupuytren's disease; CRC cis rs2658782 0.826 rs2925355 chr11:93090887 T/C cg15737290 chr11:93063684 CCDC67 0.53 7.52 0.38 5.24e-13 Pulmonary function decline; CRC cis rs62007496 0.520 rs8005906 chr14:103610845 C/T cg09274347 chr14:103599552 TNFAIP2 0.54 5.9 0.31 9.18e-9 Language performance in older adults (adjusted for episodic memory); CRC cis rs11203032 0.831 rs10887926 chr10:90940358 G/A cg16672925 chr10:90967113 CH25H 0.45 5.72 0.3 2.42e-8 Heart failure; CRC cis rs9522267 0.535 rs9522286 chr13:112230909 A/G cg26182253 chr13:112236782 NA 0.31 6.25 0.33 1.26e-9 Hepatitis; CRC cis rs13108904 0.846 rs3775100 chr4:1225106 T/C cg05665937 chr4:1216051 CTBP1 0.46 7.3 0.37 2.14e-12 Obesity-related traits; CRC cis rs9303542 0.625 rs7225995 chr17:46596268 G/C cg04904318 chr17:46607828 HOXB1 -0.57 -6.65 -0.34 1.2e-10 Ovarian cancer;Epithelial ovarian cancer; CRC cis rs644799 0.710 rs10831429 chr11:95508524 C/A cg25622487 chr11:95524042 FAM76B;CEP57 0.79 13.17 0.59 4.34e-32 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs6582630 0.519 rs8189561 chr12:38296178 G/A cg13010199 chr12:38710504 ALG10B 0.46 6.25 0.33 1.3e-9 Drug-induced liver injury (flucloxacillin); CRC cis rs12699477 0.545 rs117125814 chr7:1910681 T/G cg21782813 chr7:2030301 MAD1L1 0.39 6.87 0.35 3.25e-11 Testicular germ cell tumor; CRC trans rs7613875 0.580 rs12634780 chr3:50043341 A/T cg21665057 chr3:196295764 WDR53;FBXO45 -0.47 -7.03 -0.36 1.18e-11 Body mass index; CRC cis rs6835098 0.961 rs1574314 chr4:174106663 C/T cg08422745 chr4:174089978 GALNT7 -0.95 -15.0 -0.64 4.17e-39 Dementia and core Alzheimer's disease neuropathologic changes; CRC cis rs2243480 1.000 rs1553174 chr7:65731194 T/C cg12463550 chr7:65579703 CRCP -0.68 -6.07 -0.32 3.43e-9 Diabetic kidney disease; CRC cis rs9457247 0.765 rs6900701 chr6:167434112 A/G cg07741184 chr6:167504864 NA 0.37 6.45 0.34 4e-10 Crohn's disease; CRC cis rs28386778 0.897 rs2854213 chr17:61945631 T/C cg25654072 chr17:61904446 PSMC5;FTSJ3 0.71 10.96 0.52 4.82e-24 Prudent dietary pattern; CRC cis rs7632954 0.596 rs7611030 chr3:8511921 C/T cg03495237 chr3:8533978 NA -0.34 -6.26 -0.33 1.23e-9 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs7647973 0.961 rs62259943 chr3:49425167 A/G cg20833759 chr3:49053208 WDR6;DALRD3 -0.62 -9.2 -0.45 4.3e-18 Menarche (age at onset); CRC cis rs12580194 0.593 rs73118998 chr12:55736659 T/C cg23425280 chr12:56401806 NA 0.47 6.02 0.31 4.68e-9 Cancer; CRC cis rs172166 0.611 rs203882 chr6:28078502 G/A cg15786705 chr6:28176104 NA 0.62 8.75 0.43 1.12e-16 Cardiac Troponin-T levels; CRC cis rs728616 0.717 rs61860016 chr10:81915889 G/C cg05935833 chr10:81318306 SFTPA2 -0.71 -8.05 -0.41 1.48e-14 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs12148488 0.816 rs11854975 chr15:75363876 C/T cg05627522 chr15:75251581 NA 0.37 5.68 0.3 2.9e-8 Caffeine consumption; CRC cis rs1799949 1.000 rs12952790 chr17:41299607 A/G cg25072359 chr17:41440525 NA 0.46 6.97 0.36 1.79e-11 Menopause (age at onset); CRC cis rs2549003 0.966 rs2070730 chr5:131819800 G/A cg02551604 chr5:131831745 NA -0.54 -8.34 -0.42 2e-15 Asthma (sex interaction); CRC cis rs524281 0.637 rs7126075 chr11:65940563 T/G cg16950941 chr11:66035639 RAB1B -0.61 -7.45 -0.38 8.09e-13 Electroencephalogram traits; CRC cis rs561341 1.000 rs757009 chr17:30243937 A/G cg13647721 chr17:30228624 UTP6 0.51 5.65 0.3 3.46e-8 Hip circumference adjusted for BMI; CRC cis rs9311474 0.629 rs13081028 chr3:52555316 G/A cg15147215 chr3:52552868 STAB1 -0.78 -15.5 -0.65 4.72e-41 Electroencephalogram traits; CRC cis rs11212617 0.967 rs11212616 chr11:108281322 T/A cg12106634 chr11:108092400 ATM;NPAT 0.43 6.25 0.33 1.26e-9 Response to metformin in type 2 diabetes (glycemic); CRC cis rs7072216 0.770 rs7909131 chr10:100171471 A/G cg26618903 chr10:100175079 PYROXD2 -0.4 -6.77 -0.35 5.77e-11 Metabolite levels; CRC cis rs7208859 0.623 rs9890862 chr17:29125450 C/A cg01831904 chr17:28903510 LRRC37B2 -0.62 -6.41 -0.33 5.13e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs9682041 0.696 rs9872796 chr3:170099393 T/G cg11886554 chr3:170076028 SKIL 0.84 9.04 0.45 1.41e-17 Glomerular filtration rate in non diabetics (creatinine);Glomerular filtration rate (creatinine); CRC cis rs13315871 1.000 rs4362735 chr3:58429893 C/G cg20936604 chr3:58311152 NA -0.71 -7.11 -0.36 7.46e-12 Cholesterol, total; CRC cis rs2276314 0.857 rs28379448 chr18:33604364 C/A cg05985134 chr18:33552581 C18orf21 0.48 6.22 0.32 1.51e-9 Endometriosis;Drug-induced torsades de pointes; CRC cis rs10504229 0.593 rs1442127 chr8:57992136 T/C cg22535103 chr8:58192502 C8orf71 -0.49 -5.69 -0.3 2.77e-8 Developmental language disorder (linguistic errors); CRC cis rs3087591 0.887 rs12150521 chr17:29595108 C/T cg24425628 chr17:29625626 OMG;NF1 0.84 16.29 0.67 3.65e-44 Hip circumference; CRC cis rs7113874 0.569 rs9300092 chr11:8590492 A/G cg02811074 chr11:8615871 STK33 0.35 5.91 0.31 8.77e-9 Body mass index in physically active individuals;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs7089973 0.872 rs7094072 chr10:116627160 T/G cg03647239 chr10:116582469 FAM160B1 0.41 5.79 0.3 1.67e-8 Bipolar disorder or attention deficit hyperactivity disorder; CRC cis rs7666738 0.830 rs1111541 chr4:99033860 A/G cg17366294 chr4:99064904 C4orf37 -0.43 -7.13 -0.37 6.48e-12 Colonoscopy-negative controls vs population controls; CRC cis rs11764590 0.715 rs11760737 chr7:2104055 T/C cg23378565 chr7:2036160 MAD1L1 -0.41 -5.63 -0.3 3.94e-8 Neuroticism; CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg01866597 chr16:837896 RPUSD1;CHTF18 -0.5 -6.02 -0.31 4.64e-9 Diisocyanate-induced asthma; CRC trans rs6550704 0.687 rs9865314 chr3:22634337 A/G cg13602232 chr19:36505322 ALKBH6 -0.44 -6.5 -0.34 2.99e-10 Daytime sleep phenotypes; CRC cis rs11148252 0.538 rs9535885 chr13:52726524 A/G cg12458913 chr13:53173898 NA 0.48 7.11 0.36 7.46e-12 Lewy body disease; CRC cis rs3741404 0.620 rs11231722 chr11:63967770 C/G cg19465662 chr11:63993652 NUDT22;TRPT1 0.74 11.98 0.55 1.1e-27 Platelet count; CRC cis rs7591163 0.883 rs16824023 chr2:228720877 G/A cg20647610 chr2:228736258 WDR69 -0.45 -6.53 -0.34 2.55e-10 Blood pressure; CRC cis rs1552244 1.000 rs6781811 chr3:10121922 A/G cg18598329 chr3:10140678 FANCD2;C3orf24 0.87 12.13 0.56 2.95e-28 Alzheimer's disease; CRC cis rs6860806 0.507 rs270608 chr5:131648406 C/T cg02033258 chr5:131593261 PDLIM4 0.42 6.88 0.35 3.01e-11 Breast cancer; CRC cis rs7394190 0.748 rs1057410 chr10:75574079 G/A cg07699608 chr10:75541558 CHCHD1 0.57 5.85 0.31 1.21e-8 Incident atrial fibrillation; CRC cis rs7666738 0.830 rs17550630 chr4:99008332 G/T cg17366294 chr4:99064904 C4orf37 0.44 7.39 0.38 1.19e-12 Colonoscopy-negative controls vs population controls; CRC cis rs6951245 1.000 rs76129108 chr7:1089159 G/A cg21664854 chr7:1097933 C7orf50;GPR146 0.79 8.71 0.43 1.52e-16 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs116095464 0.558 rs56298907 chr5:283280 C/A cg22496380 chr5:211416 CCDC127 -0.98 -9.75 -0.47 6.54e-20 Breast cancer; CRC cis rs6500602 0.893 rs4786490 chr16:4491190 C/T cg14951292 chr16:4525986 HMOX2;NMRAL1 -0.5 -7.32 -0.37 1.86e-12 Schizophrenia; CRC cis rs875971 0.964 rs60193905 chr7:65971260 A/G cg18912574 chr7:65842487 NCRNA00174 0.36 6.29 0.33 1.02e-9 Aortic root size; CRC cis rs6582630 0.538 rs7971292 chr12:38498151 A/G cg26384229 chr12:38710491 ALG10B -0.54 -7.79 -0.39 8.8e-14 Drug-induced liver injury (flucloxacillin); CRC cis rs62244186 0.545 rs725866 chr3:44765533 A/G cg15687855 chr3:44754131 ZNF502 -0.34 -5.84 -0.31 1.26e-8 Depressive symptoms; CRC cis rs7044106 0.791 rs10985001 chr9:123484232 G/A cg09419670 chr9:123605666 PSMD5;LOC253039 0.73 11.99 0.55 9.92e-28 Hip circumference adjusted for BMI; CRC cis rs9309473 0.950 rs7567585 chr2:73751966 G/A cg20560298 chr2:73613845 ALMS1 -0.46 -5.61 -0.3 4.36e-8 Metabolite levels; CRC cis rs727479 0.502 rs28757200 chr15:51504061 C/T cg19946085 chr15:51559439 CYP19A1 -0.29 -5.98 -0.31 5.92e-9 Estradiol levels; CRC cis rs9467711 0.591 rs13216785 chr6:26079185 C/T cg08501292 chr6:25962987 TRIM38 0.73 7.28 0.37 2.4e-12 Autism spectrum disorder or schizophrenia; CRC cis rs727479 0.502 rs7180552 chr15:51506768 T/G cg19946085 chr15:51559439 CYP19A1 -0.3 -5.95 -0.31 6.85e-9 Estradiol levels; CRC cis rs1953600 0.645 rs2573351 chr10:81931441 A/G cg27417294 chr10:81904244 PLAC9 0.36 5.68 0.3 3e-8 Sarcoidosis; CRC cis rs727505 1.000 rs10241173 chr7:124453258 A/G cg23710748 chr7:124431027 NA -0.68 -12.16 -0.56 2.45e-28 Lewy body disease; CRC cis rs4731207 0.698 rs6945104 chr7:124557915 A/G cg23710748 chr7:124431027 NA -0.37 -5.99 -0.31 5.48e-9 Cutaneous malignant melanoma; CRC cis rs7937682 0.575 rs11604704 chr11:111764396 G/A cg19812747 chr11:111475976 SIK2 0.44 6.48 0.34 3.26e-10 Primary sclerosing cholangitis; CRC cis rs6912958 0.754 rs1051131 chr6:88221546 A/G cg08069147 chr6:88032118 GJB7;C6orf162 -0.55 -8.26 -0.41 3.58e-15 Monocyte percentage of white cells; CRC cis rs853679 0.517 rs1947862 chr6:28105196 C/T cg06470822 chr6:28175283 NA 1.0 13.3 0.59 1.3e-32 Depression; CRC cis rs10971721 0.822 rs10971763 chr9:33879777 G/A cg13495928 chr9:33750294 PRSS3 0.56 5.95 0.31 6.96e-9 Body mass index; CRC cis rs1044826 0.667 rs2083336 chr3:139201272 T/G cg15131784 chr3:139108705 COPB2 0.39 5.63 0.3 3.83e-8 Obesity-related traits; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg23260635 chr1:151584664 SNX27 0.44 6.81 0.35 4.79e-11 Intelligence (multi-trait analysis); CRC cis rs6582630 0.576 rs11504369 chr12:38274566 C/T cg26384229 chr12:38710491 ALG10B -0.43 -6.31 -0.33 9.1e-10 Drug-induced liver injury (flucloxacillin); CRC cis rs2952156 0.876 rs903501 chr17:37839493 T/C cg00129232 chr17:37814104 STARD3 -0.7 -11.85 -0.55 3.24e-27 Asthma; CRC cis rs1005277 0.540 rs2474598 chr10:38430296 C/T cg25427524 chr10:38739819 LOC399744 0.76 13.12 0.59 6.3e-32 Extrinsic epigenetic age acceleration; CRC cis rs2836950 0.501 rs11702505 chr21:40700614 G/T cg17971929 chr21:40555470 PSMG1 -0.51 -7.21 -0.37 3.76e-12 Menarche (age at onset); CRC cis rs2040771 0.745 rs2283646 chr22:19273902 A/G cg02655711 chr22:19163373 SLC25A1 -0.48 -7.56 -0.38 3.98e-13 Metabolite levels (small molecules and protein measures); CRC trans rs6544773 0.727 rs506123 chr2:45077318 C/T cg10208897 chr5:178548229 ADAMTS2 0.35 6.03 0.32 4.37e-9 Mosquito bite size; CRC cis rs2153535 0.541 rs6938688 chr6:8521629 G/T cg21535247 chr6:8435926 SLC35B3 0.47 7.33 0.37 1.83e-12 Motion sickness; CRC cis rs4819052 0.851 rs1006779 chr21:46670752 A/G cg19498844 chr21:46707878 POFUT2;LOC642852 0.69 9.95 0.48 1.47e-20 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs17376456 0.877 rs10070390 chr5:93452345 G/A cg25358565 chr5:93447407 FAM172A 0.98 10.46 0.5 2.72e-22 Diabetic retinopathy; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg27491609 chr17:62779607 LOC146880 -0.39 -6.43 -0.33 4.58e-10 Liver disease severity in Alagille syndrome; CRC cis rs7666738 0.830 rs28456179 chr4:98991439 A/G cg17366294 chr4:99064904 C4orf37 0.43 7.29 0.37 2.27e-12 Colonoscopy-negative controls vs population controls; CRC cis rs7258465 0.931 rs11673604 chr19:18540988 T/C cg01065977 chr19:18549689 ISYNA1 -0.39 -5.91 -0.31 8.64e-9 Breast cancer; CRC cis rs7258465 1.000 rs10413237 chr19:18548249 A/C cg01065977 chr19:18549689 ISYNA1 -0.42 -6.36 -0.33 6.81e-10 Breast cancer; CRC cis rs7647973 1.000 rs6805609 chr3:49471522 C/G cg20833759 chr3:49053208 WDR6;DALRD3 -0.61 -9.45 -0.46 6.73e-19 Menarche (age at onset); CRC cis rs7814319 1.000 rs2643338 chr8:97247469 A/G cg20787634 chr8:97240163 UQCRB -0.56 -9.92 -0.48 1.85e-20 Lung function (FVC); CRC cis rs7666738 0.830 rs11935078 chr4:99010476 T/A cg05340658 chr4:99064831 C4orf37 0.61 9.54 0.47 3.44e-19 Colonoscopy-negative controls vs population controls; CRC trans rs1814175 0.791 rs10769593 chr11:49616217 T/C cg11707556 chr5:10655725 ANKRD33B -0.42 -7.85 -0.4 5.91e-14 Height; CRC cis rs950169 1.000 rs1818950 chr15:84722521 A/G cg17507749 chr15:85114479 UBE2QP1 0.77 12.05 0.55 5.78e-28 Schizophrenia; CRC cis rs10504229 0.775 rs17216236 chr8:58159352 G/A cg21724239 chr8:58056113 NA 0.65 8.65 0.43 2.26e-16 Developmental language disorder (linguistic errors); CRC trans rs11098499 0.874 rs9995277 chr4:120108603 G/A cg25214090 chr10:38739885 LOC399744 0.52 7.68 0.39 1.8e-13 Corneal astigmatism; CRC cis rs13217239 0.646 rs10946897 chr6:26995251 A/C cg18867708 chr6:26865862 GUSBL1 0.37 5.74 0.3 2.17e-8 Schizophrenia; CRC cis rs3617 0.572 rs2256332 chr3:52855865 A/G cg11645453 chr3:52864694 ITIH4 -0.47 -9.38 -0.46 1.14e-18 Red blood cell count;Autism spectrum disorder or schizophrenia; CRC cis rs270601 0.661 rs10036208 chr5:131571323 T/C cg20512303 chr5:131592959 PDLIM4 0.42 7.36 0.38 1.44e-12 Acylcarnitine levels; CRC cis rs11997175 0.603 rs12234894 chr8:33699275 G/C cg04338863 chr8:33670619 NA 0.43 6.76 0.35 6.28e-11 Body mass index; CRC cis rs7613875 0.620 rs3774734 chr3:50108792 C/A cg05623727 chr3:50126028 RBM5 -0.6 -10.31 -0.49 8.96e-22 Body mass index; CRC cis rs9325144 0.647 rs870431 chr12:38953073 T/C cg26384229 chr12:38710491 ALG10B -0.52 -7.45 -0.38 8.54e-13 Morning vs. evening chronotype; CRC cis rs9916302 0.706 rs667193 chr17:37448835 T/C cg15445000 chr17:37608096 MED1 -0.33 -5.76 -0.3 1.9e-8 Glomerular filtration rate (creatinine); CRC trans rs2303319 0.504 rs62189053 chr2:162624324 G/A cg22902534 chr3:183892754 AP2M1 -0.7 -6.07 -0.32 3.56e-9 Cognitive function; CRC cis rs9534288 0.797 rs2104515 chr13:46569846 T/C cg15192986 chr13:46630673 CPB2 -0.67 -9.85 -0.48 3.16e-20 Blood protein levels; CRC cis rs7843479 0.582 rs7009693 chr8:21775314 C/T cg17168535 chr8:21777572 XPO7 0.65 11.49 0.54 6.32e-26 Mean corpuscular volume; CRC cis rs9894429 0.646 rs8079963 chr17:79603285 C/T cg18240062 chr17:79603768 NPLOC4 0.48 7.55 0.38 4.32e-13 Eye color traits; CRC cis rs11190604 1.000 rs2495739 chr10:102335507 C/T cg07080220 chr10:102295463 HIF1AN 0.47 5.92 0.31 8.17e-9 Palmitoleic acid (16:1n-7) levels; CRC cis rs17023223 0.537 rs2645295 chr1:119582448 C/T cg05756136 chr1:119680316 WARS2 -0.45 -6.19 -0.32 1.77e-9 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for BMI in active individuals; CRC cis rs3018066 0.748 rs6823347 chr4:106962725 G/A cg01869342 chr4:106983673 TBCK 0.43 6.39 0.33 5.72e-10 Cancer; CRC cis rs875971 0.628 rs6974355 chr7:65841981 A/G cg18876405 chr7:65276391 NA 0.62 10.74 0.51 2.84e-23 Aortic root size; CRC cis rs8103278 1.000 rs7256192 chr19:46338492 G/A cg20908204 chr19:46285434 DMPK -0.35 -6.81 -0.35 4.77e-11 Coronary artery disease; CRC cis rs447 1.000 rs6977099 chr7:83762428 C/A cg22846510 chr7:83753280 SEMA3A -0.61 -7.8 -0.39 8.35e-14 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC trans rs1005277 0.579 rs2474567 chr10:38382492 C/T cg27523141 chr10:43048294 ZNF37B 0.49 7.21 0.37 3.99e-12 Extrinsic epigenetic age acceleration; CRC cis rs7937682 0.681 rs2156580 chr11:111394328 C/G cg09085632 chr11:111637200 PPP2R1B 0.56 7.57 0.39 3.68e-13 Primary sclerosing cholangitis; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg22745781 chr7:16461244 ISPD 0.38 6.32 0.33 8.56e-10 Liver disease severity in Alagille syndrome; CRC cis rs9858542 0.953 rs6997 chr3:49453834 C/T cg03060546 chr3:49711283 APEH -0.47 -6.57 -0.34 1.93e-10 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs4481887 0.790 rs4526648 chr1:248422503 A/T cg00666640 chr1:248458726 OR2T12 -0.47 -8.07 -0.41 1.3e-14 Common traits (Other); CRC cis rs6502050 0.835 rs4789738 chr17:80123053 G/A cg25804541 chr17:80189381 SLC16A3 -0.31 -5.95 -0.31 6.84e-9 Life satisfaction; CRC cis rs208520 0.690 rs2208442 chr6:66867004 T/C cg07460842 chr6:66804631 NA -1.07 -14.89 -0.63 1.12e-38 Exhaled nitric oxide output; CRC trans rs3733585 0.673 rs4311316 chr4:9955971 A/C cg26043149 chr18:55253948 FECH 0.49 7.44 0.38 8.59e-13 Cleft plate (environmental tobacco smoke interaction); CRC cis rs7849270 1.000 rs3739843 chr9:131882961 G/A cg13538475 chr9:131942899 NA -0.29 -5.83 -0.31 1.32e-8 Blood metabolite ratios; CRC cis rs1519814 0.956 rs6469900 chr8:121117378 C/T cg22335954 chr8:121166405 COL14A1 -0.55 -6.19 -0.32 1.77e-9 Breast cancer; CRC trans rs2898290 0.500 rs11998678 chr8:11830150 A/G cg06636001 chr8:8085503 FLJ10661 -0.54 -7.77 -0.39 1.02e-13 Systolic blood pressure; CRC cis rs9491140 0.539 rs11154231 chr6:124687586 T/C cg22366943 chr6:124882293 NKAIN2 0.56 8.44 0.42 1.05e-15 Neuroticism; CRC cis rs7809950 1.000 rs2520269 chr7:107191327 T/C cg23024343 chr7:107201750 COG5 -0.64 -9.03 -0.45 1.53e-17 Coronary artery disease; CRC cis rs10883723 0.668 rs12414407 chr10:104387019 A/G cg22532475 chr10:104410764 TRIM8 0.33 5.94 0.31 7.35e-9 Allergic disease (asthma, hay fever or eczema); CRC cis rs2952156 0.920 rs2934956 chr17:37830447 T/A cg20243544 chr17:37824526 PNMT 0.56 9.02 0.45 1.59e-17 Asthma; CRC cis rs801193 1.000 rs7785213 chr7:66138978 A/C cg11764359 chr7:65958608 NA -0.55 -8.41 -0.42 1.26e-15 Aortic root size; CRC cis rs6545883 0.868 rs28749199 chr2:61827052 A/G cg15711740 chr2:61764176 XPO1 -0.53 -7.13 -0.37 6.34e-12 Tuberculosis; CRC cis rs3858526 0.676 rs10838752 chr11:5887243 A/G cg02574844 chr11:5959923 NA -0.42 -5.82 -0.31 1.38e-8 DNA methylation (variation); CRC cis rs11190604 1.000 rs4919466 chr10:102241213 T/C cg07080220 chr10:102295463 HIF1AN 0.47 5.86 0.31 1.1e-8 Palmitoleic acid (16:1n-7) levels; CRC cis rs989128 0.600 rs9913677 chr17:48628581 T/A cg24438145 chr17:48624694 SPATA20 0.44 6.42 0.33 4.72e-10 Type 2 diabetes; CRC trans rs9567307 1 rs9567307 chr13:44471877 A/G cg12856521 chr11:46389249 DGKZ 0.58 8.55 0.43 4.7e-16 Leprosy; CRC cis rs780096 0.565 rs8179252 chr2:27746832 A/C cg24768116 chr2:27665128 KRTCAP3 -0.34 -7.7 -0.39 1.61e-13 Total body bone mineral density; CRC cis rs10489202 0.683 rs7515429 chr1:168066659 A/G cg24449463 chr1:168025552 DCAF6 -0.53 -7.34 -0.38 1.69e-12 Schizophrenia; CRC cis rs1997103 1.000 rs2331068 chr7:55408220 G/A cg17469321 chr7:55412551 NA 0.72 11.28 0.53 3.48e-25 QRS interval (sulfonylurea treatment interaction); CRC cis rs2204008 0.837 rs11180549 chr12:38236950 A/G cg26384229 chr12:38710491 ALG10B 0.7 9.31 0.46 1.92e-18 Bladder cancer; CRC cis rs58688157 0.880 rs12272314 chr11:590648 A/G cg14433983 chr11:636460 DRD4 -0.42 -6.09 -0.32 3.15e-9 Systemic lupus erythematosus; CRC cis rs858239 0.699 rs955187 chr7:23194605 A/G cg00469287 chr7:23338798 C7orf30 -0.43 -5.68 -0.3 3.01e-8 Cerebrospinal fluid biomarker levels; CRC trans rs7618501 0.735 rs9876508 chr3:49780844 G/A cg21665057 chr3:196295764 WDR53;FBXO45 -0.86 -15.78 -0.66 3.79e-42 Intelligence (multi-trait analysis); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg03586379 chr3:140660603 SLC25A36 0.42 6.83 0.35 4.12e-11 Liver disease severity in Alagille syndrome; CRC cis rs875971 0.862 rs10950033 chr7:65739673 A/G cg18252515 chr7:66147081 NA 0.4 5.77 0.3 1.82e-8 Aortic root size; CRC cis rs72717009 0.825 rs7539468 chr1:161477066 G/A cg15358701 chr1:161410459 NA -0.62 -6.63 -0.34 1.39e-10 Rheumatoid arthritis; CRC cis rs7772486 0.875 rs7766595 chr6:146364507 A/T cg23711669 chr6:146136114 FBXO30 0.68 11.85 0.55 3.22e-27 Lobe attachment (rater-scored or self-reported); CRC cis rs7927771 1.000 rs7947730 chr11:47786184 C/T cg05585544 chr11:47624801 NA -0.62 -10.82 -0.51 1.47e-23 Subjective well-being; CRC cis rs72945132 0.714 rs115143889 chr11:70150122 G/T cg14191688 chr11:70257035 CTTN 0.47 6.03 0.32 4.39e-9 Coronary artery disease; CRC cis rs7584330 0.868 rs13386290 chr2:238393136 G/C cg16989719 chr2:238392110 NA -0.49 -9.5 -0.46 4.65e-19 Prostate cancer; CRC cis rs2239547 0.603 rs9870898 chr3:53092375 A/G cg11645453 chr3:52864694 ITIH4 0.5 8.21 0.41 4.97e-15 Schizophrenia; CRC cis rs10504229 0.728 rs59266065 chr8:58156236 A/G cg24829409 chr8:58192753 C8orf71 -0.6 -8.09 -0.41 1.16e-14 Developmental language disorder (linguistic errors); CRC cis rs853679 0.550 rs1233704 chr6:28166923 A/G cg12172441 chr6:28176163 NA -0.69 -9.38 -0.46 1.13e-18 Depression; CRC cis rs798502 0.522 rs7790322 chr7:2830498 C/T cg09658497 chr7:2847517 GNA12 -0.43 -6.62 -0.34 1.48e-10 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Inflammatory bowel disease;Waist circumference adjusted for BMI in non-smokers;Ulcerative colitis;Waist circumference adjusted for body mass index;Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction); CRC cis rs1223397 0.938 rs34505804 chr6:13292514 G/A cg06879394 chr6:13274151 PHACTR1 0.53 6.21 0.32 1.57e-9 Blood pressure; CRC cis rs1799949 0.930 rs66499067 chr17:41248484 G/C cg05368731 chr17:41323189 NBR1 0.65 9.44 0.46 6.99e-19 Menopause (age at onset); CRC cis rs6831352 0.760 rs1311616 chr4:100012303 T/G cg13256891 chr4:100009986 ADH5 0.63 8.4 0.42 1.39e-15 Alcohol dependence; CRC cis rs3858526 0.883 rs4758183 chr11:5925178 C/G cg02574844 chr11:5959923 NA -0.41 -5.66 -0.3 3.34e-8 DNA methylation (variation); CRC trans rs10504229 0.953 rs115634610 chr8:58190533 G/A cg04077850 chr5:125800366 GRAMD3 0.37 6.26 0.33 1.23e-9 Developmental language disorder (linguistic errors); CRC cis rs977987 0.806 rs35683383 chr16:75479277 G/T cg03315344 chr16:75512273 CHST6 0.54 9.33 0.46 1.58e-18 Dupuytren's disease; CRC cis rs7174755 0.637 rs113002386 chr15:68464713 C/T cg22576950 chr15:68522787 CLN6 0.38 5.94 0.31 7.2e-9 Major depressive disorder; CRC cis rs2739330 0.627 rs9608219 chr22:24274119 G/C cg11905131 chr22:24372483 LOC391322 -0.69 -10.79 -0.51 1.88e-23 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs644799 0.562 rs515546 chr11:95588756 G/C cg25622487 chr11:95524042 FAM76B;CEP57 0.55 8.26 0.41 3.59e-15 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs2836974 0.583 rs9636957 chr21:40705847 G/A cg06238570 chr21:40685208 BRWD1 -0.78 -12.09 -0.55 4.45e-28 Cognitive function; CRC cis rs35306767 0.903 rs10508208 chr10:910983 C/T cg20503657 chr10:835505 NA 0.97 11.93 0.55 1.69e-27 Eosinophil percentage of granulocytes; CRC cis rs425277 1.000 rs385039 chr1:2077409 C/T cg24578937 chr1:2090814 PRKCZ -0.63 -11.37 -0.53 1.69e-25 Height; CRC cis rs4713675 0.584 rs3818527 chr6:33661035 A/G cg14003231 chr6:33640908 ITPR3 -0.49 -7.84 -0.4 6.43e-14 Plateletcrit; CRC cis rs4237845 0.537 rs2002275 chr12:58283385 A/G cg02175503 chr12:58329896 NA 0.48 6.02 0.32 4.64e-9 Intelligence (multi-trait analysis); CRC cis rs2124969 0.548 rs72982036 chr2:161031590 G/A cg03641300 chr2:160917029 PLA2R1 -0.65 -8.45 -0.42 9.47e-16 Waist circumference adjusted for body mass index; CRC cis rs1728785 1.000 rs7205960 chr16:68565604 G/C cg02972257 chr16:68554789 NA -0.57 -6.98 -0.36 1.64e-11 Ulcerative colitis; CRC cis rs875971 0.522 rs1917563 chr7:65415647 C/T cg18876405 chr7:65276391 NA -0.66 -12.12 -0.56 3.43e-28 Aortic root size; CRC cis rs727505 0.607 rs17387389 chr7:124784751 T/C cg23710748 chr7:124431027 NA -0.64 -10.24 -0.49 1.56e-21 Lewy body disease; CRC cis rs9311474 0.967 rs610060 chr3:52273421 G/A cg15147215 chr3:52552868 STAB1 0.6 10.09 0.49 4.9e-21 Electroencephalogram traits; CRC cis rs9359856 0.564 rs56084221 chr6:90365349 T/C cg13799429 chr6:90582589 CASP8AP2 -0.74 -8.12 -0.41 9.21e-15 Bipolar disorder; CRC cis rs6674176 0.660 rs12726706 chr1:44399942 G/A cg13606994 chr1:44402422 ARTN -0.36 -6.07 -0.32 3.53e-9 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Cognitive ability; CRC cis rs2153535 0.580 rs1832100 chr6:8446956 G/A cg21535247 chr6:8435926 SLC35B3 0.5 7.53 0.38 4.92e-13 Motion sickness; CRC cis rs4478858 0.735 rs12126725 chr1:31805853 G/T cg00250761 chr1:31883323 NA -0.44 -8.5 -0.42 6.71e-16 Alcohol dependence; CRC cis rs763121 0.752 rs5757222 chr22:39060473 C/T cg06022373 chr22:39101656 GTPBP1 0.79 12.53 0.57 1.01e-29 Menopause (age at onset); CRC cis rs780096 0.526 rs11126999 chr2:27670307 G/A cg21248554 chr2:27665150 KRTCAP3 -0.33 -7.41 -0.38 1.09e-12 Total body bone mineral density; CRC cis rs9660180 0.868 rs72634846 chr1:1704915 C/G cg13866156 chr1:1669148 SLC35E2 -0.63 -9.79 -0.47 4.97e-20 Body mass index; CRC cis rs4713118 0.955 rs9468201 chr6:27687035 C/T cg03623178 chr6:28175578 NA 0.63 8.42 0.42 1.21e-15 Parkinson's disease; CRC cis rs1223397 0.938 rs17700321 chr6:13280666 G/T cg21538684 chr6:13274180 PHACTR1 0.46 5.64 0.3 3.58e-8 Blood pressure; CRC trans rs916888 0.773 rs1378358 chr17:44787312 C/T cg22968622 chr17:43663579 NA 1.39 17.14 0.69 1.59e-47 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs9303401 0.659 rs16943176 chr17:56769887 G/A cg10487724 chr17:56770010 TEX14;RAD51C 0.79 10.0 0.48 1.01e-20 Cognitive test performance; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg27184628 chr4:17616433 MED28 0.44 6.21 0.32 1.6e-9 Response to antipsychotic treatment; CRC cis rs898097 0.841 rs11656358 chr17:80853956 G/A cg15664640 chr17:80829946 TBCD -0.69 -11.49 -0.54 6.36e-26 Breast cancer; CRC cis rs9858542 1.000 rs2172252 chr3:49678307 A/T cg00383909 chr3:49044727 WDR6 0.46 5.73 0.3 2.3e-8 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC trans rs11252926 1.000 rs11252926 chr10:566379 C/T cg00953403 chr17:74099816 EXOC7 -0.46 -6.3 -0.33 9.47e-10 Psychosis in Alzheimer's disease; CRC cis rs1967309 0.604 rs8061182 chr16:4070333 A/G cg00061520 chr16:4070371 ADCY9 0.39 6.21 0.32 1.57e-9 Response to Dalcetrapib treatment in acute coronary syndrome; CRC cis rs514406 0.760 rs475969 chr1:53292607 T/A cg25767906 chr1:53392781 SCP2 -0.52 -8.29 -0.42 2.92e-15 Monocyte count; CRC cis rs60871478 0.730 rs13222476 chr7:826630 T/C cg13844804 chr7:814759 HEATR2 0.69 8.16 0.41 7.04e-15 Cerebrospinal P-tau181p levels; CRC cis rs208346 1.000 rs208346 chr7:2799686 G/T cg19717773 chr7:2847554 GNA12 0.43 7.64 0.39 2.44e-13 Loneliness (linear analysis); CRC cis rs11098499 0.863 rs6858592 chr4:120458692 G/A cg24375607 chr4:120327624 NA 0.49 7.44 0.38 8.62e-13 Corneal astigmatism; CRC cis rs77972916 0.505 rs34247383 chr2:43532780 A/C cg06169590 chr2:43455088 ZFP36L2;LOC100129726 -0.57 -6.21 -0.32 1.59e-9 Granulocyte percentage of myeloid white cells; CRC cis rs12142240 0.698 rs72890727 chr1:46860237 G/A cg00530320 chr1:46809349 NSUN4 0.59 8.07 0.41 1.35e-14 Menopause (age at onset); CRC cis rs394563 0.591 rs237019 chr6:149727064 G/A cg16235748 chr6:149772707 ZC3H12D -0.37 -6.71 -0.35 8.56e-11 Dupuytren's disease; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg16082007 chr3:134093380 AMOTL2 0.42 6.03 0.32 4.3e-9 Intelligence (multi-trait analysis); CRC cis rs9787249 0.957 rs7518431 chr1:40214944 C/T cg24920358 chr1:40204285 PPIE -0.57 -8.61 -0.43 3.18e-16 Blood protein levels; CRC trans rs1814175 0.817 rs11040474 chr11:49708441 G/A cg15704280 chr7:45808275 SEPT13 -1.01 -20.49 -0.75 9.84e-61 Height; CRC cis rs10992471 0.756 rs10992303 chr9:95082804 A/G cg13798575 chr9:95087839 CENPP;NOL8 -0.48 -6.89 -0.36 2.8e-11 Visceral adipose tissue/subcutaneous adipose tissue ratio; CRC cis rs6754311 0.773 rs4988226 chr2:136610598 A/G cg15123519 chr2:136567270 LCT 0.34 6.57 0.34 1.94e-10 Mosquito bite size; CRC cis rs11148252 0.846 rs8001624 chr13:53002995 T/C cg12458913 chr13:53173898 NA 0.52 8.02 0.4 1.88e-14 Lewy body disease; CRC cis rs728616 0.681 rs55899456 chr10:82050646 G/A cg05935833 chr10:81318306 SFTPA2 -0.61 -7.1 -0.36 7.55e-12 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs2439831 0.850 rs7168158 chr15:44050376 G/A cg02155558 chr15:43621948 ADAL;LCMT2 0.68 7.47 0.38 7.38e-13 Lung cancer in ever smokers; CRC cis rs780096 0.506 rs1647286 chr2:27714517 A/T cg17158414 chr2:27665306 KRTCAP3 -0.32 -7.17 -0.37 5.01e-12 Total body bone mineral density; CRC cis rs1865760 0.566 rs9295686 chr6:26081983 G/C cg17691542 chr6:26056736 HIST1H1C 0.56 8.51 0.42 6.1e-16 Height; CRC cis rs10256972 0.706 rs12701970 chr7:1121958 T/C cg07308232 chr7:1071921 C7orf50 -0.46 -6.17 -0.32 1.99e-9 Longevity;Endometriosis; CRC cis rs4930103 0.935 rs2525881 chr11:2019333 T/C cg06197492 chr11:2016605 H19 0.41 6.42 0.33 4.72e-10 DNA methylation (parent-of-origin);DNA methylation (variation); CRC cis rs2286885 0.965 rs4837091 chr9:129244928 A/G cg15282417 chr9:129245246 FAM125B 0.44 8.06 0.41 1.46e-14 Intraocular pressure; CRC cis rs1799949 1.000 rs4793194 chr17:41218333 G/A cg19454999 chr17:41278357 BRCA1;NBR2 0.55 8.62 0.43 2.83e-16 Menopause (age at onset); CRC cis rs4285028 0.948 rs79103597 chr3:121667629 C/T cg20356878 chr3:121714668 ILDR1 -0.48 -6.92 -0.36 2.43e-11 Multiple sclerosis; CRC trans rs916888 0.647 rs199449 chr17:44808902 G/A cg01341218 chr17:43662625 NA 0.6 7.48 0.38 6.9e-13 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs1882538 0.564 rs10488164 chr7:133106199 A/G cg10665199 chr7:133106180 EXOC4 0.71 11.6 0.54 2.59e-26 Intelligence (multi-trait analysis); CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg07560096 chr11:86383182 ME3 -0.5 -6.15 -0.32 2.21e-9 Diisocyanate-induced asthma; CRC cis rs6570726 0.791 rs414600 chr6:145879606 G/A cg13319975 chr6:146136371 FBXO30 -0.45 -6.59 -0.34 1.78e-10 Lobe attachment (rater-scored or self-reported); CRC cis rs8103278 1.000 rs36091860 chr19:46312880 G/A cg20908204 chr19:46285434 DMPK -0.35 -7.01 -0.36 1.38e-11 Coronary artery disease; CRC cis rs7309 0.935 rs1921309 chr2:162048975 T/A cg22496339 chr2:162101262 NA 0.78 13.2 0.59 3.24e-32 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Educational attainment; CRC cis rs73206853 0.534 rs12302069 chr12:110512359 A/G cg12870014 chr12:110450643 ANKRD13A 0.86 8.85 0.44 5.65e-17 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC cis rs1552244 0.938 rs56274701 chr3:10167790 G/A cg16606324 chr3:10149918 C3orf24 0.71 9.42 0.46 7.95e-19 Alzheimer's disease; CRC cis rs8016982 0.962 rs8007841 chr14:81647878 C/T cg01989461 chr14:81687754 GTF2A1 -0.4 -5.66 -0.3 3.34e-8 Schizophrenia; CRC cis rs13315871 1.000 rs71311857 chr3:58323377 A/G cg20936604 chr3:58311152 NA -0.78 -7.38 -0.38 1.34e-12 Cholesterol, total; CRC cis rs9322193 0.962 rs9397022 chr6:150133188 C/T cg05861140 chr6:150128134 PCMT1 -0.41 -6.58 -0.34 1.8e-10 Lung cancer; CRC cis rs919433 0.679 rs7564924 chr2:198513877 C/T cg00792783 chr2:198669748 PLCL1 0.29 5.6 0.3 4.49e-8 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC cis rs1799949 0.965 rs33988650 chr17:41287880 A/G cg19454999 chr17:41278357 BRCA1;NBR2 0.55 8.65 0.43 2.28e-16 Menopause (age at onset); CRC cis rs9398803 0.865 rs2326451 chr6:126811928 A/T cg19875578 chr6:126661172 C6orf173 0.44 6.27 0.33 1.16e-9 Male-pattern baldness; CRC cis rs13064411 0.696 rs9836396 chr3:113184282 T/C cg10517650 chr3:113235015 CCDC52 -0.37 -6.58 -0.34 1.83e-10 Response to simvastatin treatment (PCSK9 protein level change); CRC cis rs12477438 0.520 rs2171359 chr2:99795360 T/C cg14399236 chr2:99771627 LIPT1;TSGA10 0.81 14.32 0.62 1.66e-36 Chronic sinus infection; CRC cis rs1865760 0.516 rs10807007 chr6:26048931 A/C cg18357526 chr6:26021779 HIST1H4A 0.43 6.07 0.32 3.55e-9 Height; CRC cis rs4285028 0.948 rs76593525 chr3:121690477 G/A cg20356878 chr3:121714668 ILDR1 -0.48 -6.91 -0.36 2.51e-11 Multiple sclerosis; CRC cis rs755249 0.567 rs4660543 chr1:39678990 A/G cg18385671 chr1:39797026 MACF1 -0.44 -6.36 -0.33 6.62e-10 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs13108904 0.967 rs1732107 chr4:1276758 G/A cg16405210 chr4:1374714 KIAA1530 0.41 5.76 0.3 1.96e-8 Obesity-related traits; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg01772563 chr7:95064399 PON2 0.39 6.02 0.31 4.57e-9 Liver disease severity in Alagille syndrome; CRC cis rs172166 0.694 rs203893 chr6:28062066 C/A cg12273811 chr6:28175739 NA 0.63 9.13 0.45 6.88e-18 Cardiac Troponin-T levels; CRC cis rs10504073 0.647 rs4873317 chr8:50021111 C/T cg00325661 chr8:49890786 NA 0.52 9.3 0.46 1.98e-18 Blood metabolite ratios; CRC cis rs6938 0.534 rs8025447 chr15:75192222 T/G cg18612461 chr15:75251733 NA 0.38 5.87 0.31 1.06e-8 Breast cancer; CRC cis rs2836974 0.568 rs419469 chr21:40537234 C/T cg11644478 chr21:40555479 PSMG1 0.72 12.01 0.55 8.56e-28 Cognitive function; CRC cis rs951366 0.789 rs864783 chr1:205711974 T/C cg24503407 chr1:205819492 PM20D1 0.81 12.48 0.57 1.62e-29 Menarche (age at onset); CRC cis rs881375 0.933 rs1548784 chr9:123685280 T/C cg09586646 chr9:123605570 PSMD5;LOC253039 0.47 6.39 0.33 5.51e-10 Rheumatoid arthritis; CRC cis rs9479482 0.967 rs61730071 chr6:150342232 G/A cg25797454 chr6:150327115 RAET1K 0.37 6.25 0.33 1.25e-9 Alopecia areata; CRC trans rs7937682 0.889 rs578022 chr11:111490552 G/T cg18187862 chr3:45730750 SACM1L 0.45 6.55 0.34 2.23e-10 Primary sclerosing cholangitis; CRC cis rs847851 0.630 rs9462021 chr6:34758640 C/T cg07306190 chr6:34760872 UHRF1BP1 -0.34 -6.1 -0.32 3.05e-9 Colonoscopy-negative controls vs population controls; CRC cis rs10504229 0.645 rs35142596 chr8:58128151 C/T cg24829409 chr8:58192753 C8orf71 -0.55 -8.03 -0.4 1.71e-14 Developmental language disorder (linguistic errors); CRC cis rs1065656 0.581 rs1065663 chr16:1839023 G/A cg00046913 chr16:1877150 HAGH;FAHD1 0.53 5.84 0.31 1.27e-8 Insulin-like growth factors; CRC cis rs9322193 0.923 rs2185352 chr6:150035776 T/G cg05861140 chr6:150128134 PCMT1 -0.36 -5.85 -0.31 1.18e-8 Lung cancer; CRC cis rs9368481 0.546 rs12664610 chr6:26885031 G/A cg18867708 chr6:26865862 GUSBL1 0.43 6.21 0.32 1.6e-9 Autism spectrum disorder or schizophrenia; CRC cis rs1865760 0.566 rs2051544 chr6:26071093 C/T cg18357526 chr6:26021779 HIST1H4A 0.41 5.79 0.3 1.64e-8 Height; CRC cis rs4423214 0.879 rs1790353 chr11:71136730 C/T cg05163923 chr11:71159392 DHCR7 -0.65 -7.91 -0.4 3.94e-14 Vitamin D levels; CRC cis rs8141529 0.504 rs6005915 chr22:29233262 A/G cg02153584 chr22:29168773 CCDC117 0.47 6.35 0.33 7.15e-10 Lymphocyte counts; CRC cis rs7811142 1.000 rs11764818 chr7:100043055 G/A cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.19 17.69 0.7 1.13e-49 Platelet count; CRC cis rs12950390 0.853 rs4794107 chr17:45843159 T/G cg24803719 chr17:45855879 NA -0.3 -6.57 -0.34 2.02e-10 IgG glycosylation; CRC cis rs5758511 0.637 rs5751244 chr22:42617411 T/C cg00645731 chr22:42541494 CYP2D7P1 0.64 9.78 0.47 5.32e-20 Birth weight; CRC cis rs60871478 1.000 rs34260834 chr7:822958 A/G cg05535760 chr7:792225 HEATR2 0.83 11.47 0.53 7.62e-26 Cerebrospinal P-tau181p levels; CRC cis rs7927771 0.965 rs56400411 chr11:47586376 T/G cg20307385 chr11:47447363 PSMC3 -0.55 -7.75 -0.39 1.19e-13 Subjective well-being; CRC trans rs1814175 0.904 rs1846289 chr11:49620253 G/A cg03929089 chr4:120376271 NA -0.94 -17.32 -0.69 3.26e-48 Height; CRC cis rs13191362 1.000 rs34228197 chr6:163008232 A/G cg21926612 chr6:163149169 PACRG;PARK2 0.74 10.83 0.51 1.37e-23 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs6951245 0.786 rs77943789 chr7:1140158 C/T cg22907277 chr7:1156413 C7orf50 0.78 8.85 0.44 5.33e-17 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs2455601 0.786 rs56680262 chr11:8971555 C/T cg21881798 chr11:8931708 C11orf17;ST5 -0.57 -6.56 -0.34 2.05e-10 Schizophrenia; CRC cis rs57221529 0.709 rs72703034 chr5:577101 C/T cg17948913 chr5:572064 NA 0.56 6.25 0.33 1.28e-9 Lung disease severity in cystic fibrosis; CRC cis rs1552244 1.000 rs6768102 chr3:10149380 A/G cg10729496 chr3:10149963 C3orf24 0.53 6.92 0.36 2.41e-11 Alzheimer's disease; CRC cis rs7274811 0.744 rs34489266 chr20:32223040 A/G cg07470512 chr20:32255052 NECAB3;C20orf134 -0.44 -5.77 -0.3 1.8e-8 Height; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg03201274 chr1:27693242 MAP3K6 0.45 6.97 0.36 1.74e-11 Response to antipsychotic treatment; CRC cis rs60871478 0.636 rs4721600 chr7:871728 C/T cg13798912 chr7:905769 UNC84A -0.62 -6.67 -0.35 1.08e-10 Cerebrospinal P-tau181p levels; CRC cis rs2227564 0.620 rs4746143 chr10:75477298 A/G cg00564723 chr10:75632066 CAMK2G -0.32 -7.62 -0.39 2.8e-13 Crohn's disease;Inflammatory bowel disease; CRC cis rs17234274 0.622 rs1586076 chr11:23237286 T/C cg05245346 chr11:23248277 NA 0.34 5.63 0.3 3.79e-8 Cancer; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg12484590 chr1:156475177 NA 0.46 6.6 0.34 1.61e-10 Response to antipsychotic treatment; CRC cis rs4665809 1.000 rs6704930 chr2:26325705 G/A cg25036284 chr2:26402008 FAM59B -0.46 -5.97 -0.31 6e-9 Gut microbiome composition (summer); CRC trans rs5756813 0.635 rs6000899 chr22:38203796 C/T cg19894588 chr14:64061835 NA -0.62 -8.41 -0.42 1.3e-15 Optic cup area;Vertical cup-disc ratio; CRC cis rs2204008 0.555 rs7310307 chr12:38107497 G/T cg26384229 chr12:38710491 ALG10B 0.7 8.92 0.44 3.2e-17 Bladder cancer; CRC cis rs2749592 0.531 rs994804 chr10:37900140 A/C cg00409905 chr10:38381863 ZNF37A 0.58 9.35 0.46 1.41e-18 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs1570884 0.516 rs7334387 chr13:50172133 T/A cg08779649 chr13:50194554 NA 0.44 9.23 0.45 3.49e-18 Sum basophil neutrophil counts;Sum neutrophil eosinophil counts;Neutrophil count;Myeloid white cell count;Granulocyte count; CRC cis rs9517320 0.534 rs9554474 chr13:99140871 G/A cg07423050 chr13:99094983 FARP1 -0.55 -7.86 -0.4 5.67e-14 Longevity; CRC cis rs1046896 0.552 rs12602280 chr17:80805421 G/C cg19046167 chr17:80928561 B3GNTL1 0.49 6.67 0.35 1.09e-10 Glycated hemoglobin levels; CRC cis rs67311347 0.911 rs6775936 chr3:40377399 T/G cg09455208 chr3:40491958 NA 0.45 8.96 0.44 2.41e-17 Renal cell carcinoma; CRC trans rs11026407 0.967 rs7127246 chr11:22060228 C/G cg17809276 chr1:172501547 C1orf9 -0.59 -5.99 -0.31 5.46e-9 Plasma thyroid-stimulating hormone levels; CRC cis rs9914988 0.943 rs9891925 chr17:27104540 A/T cg16670446 chr17:27188758 MIR451;MIR144 0.55 8.52 0.43 5.75e-16 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs10461617 0.617 rs79742142 chr5:56104377 A/G cg12311346 chr5:56204834 C5orf35 -0.8 -10.38 -0.5 4.95e-22 Type 2 diabetes; CRC cis rs12950390 0.853 rs8071192 chr17:45856141 A/G cg24803719 chr17:45855879 NA -0.32 -7.14 -0.37 5.94e-12 IgG glycosylation; CRC cis rs951366 0.966 rs11240565 chr1:205722958 C/T cg24503407 chr1:205819492 PM20D1 -0.44 -6.22 -0.32 1.49e-9 Menarche (age at onset); CRC cis rs4908768 0.501 rs6677736 chr1:8552804 A/T cg20416874 chr1:8611966 RERE -0.45 -6.42 -0.33 4.68e-10 Neuroticism (multi-trait analysis);Subjective well-being (multi-trait analysis); CRC cis rs11997175 0.713 rs4327826 chr8:33654807 T/G ch.8.33884649F chr8:33765107 NA 0.37 5.73 0.3 2.22e-8 Body mass index; CRC cis rs12451471 0.559 rs34746710 chr17:78079224 G/A cg21238619 chr17:78079768 GAA -0.34 -5.76 -0.3 1.95e-8 Plateletcrit;Mean corpuscular hemoglobin concentration; CRC cis rs2243480 1.000 rs7456042 chr7:65299778 T/C cg12463550 chr7:65579703 CRCP 0.67 6.15 0.32 2.2e-9 Diabetic kidney disease; CRC cis rs644799 0.664 rs603625 chr11:95554283 G/A cg25478527 chr11:95522999 CEP57;FAM76B 0.5 7.79 0.39 8.61e-14 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs959260 0.541 rs58935635 chr17:73357744 C/T cg14668889 chr17:73230827 NUP85 0.49 5.68 0.3 2.93e-8 Systemic lupus erythematosus; CRC cis rs7086803 1.000 rs7088860 chr10:114486867 A/G cg03281572 chr10:114502318 VTI1A 0.68 5.7 0.3 2.62e-8 Lung cancer; CRC cis rs7909074 0.966 rs4245614 chr10:45397007 C/T cg05187965 chr10:45406764 TMEM72 -0.36 -8.23 -0.41 4.39e-15 Mean corpuscular volume; CRC cis rs6938 0.618 rs11638130 chr15:75183935 G/A cg17294928 chr15:75287854 SCAMP5 0.56 8.62 0.43 2.81e-16 Breast cancer; CRC cis rs1018836 0.923 rs9693182 chr8:91621876 T/C cg16814680 chr8:91681699 NA -0.77 -12.18 -0.56 1.96e-28 Ejection fraction in Tripanosoma cruzi seropositivity; CRC cis rs6502050 0.835 rs6502065 chr17:80095642 T/C cg09264619 chr17:80180166 NA -0.34 -5.81 -0.3 1.5e-8 Life satisfaction; CRC cis rs6921919 0.583 rs6928773 chr6:28375210 T/C cg21251018 chr6:28226885 NKAPL 0.4 6.12 0.32 2.61e-9 Autism spectrum disorder or schizophrenia; CRC cis rs6570726 0.967 rs365515 chr6:145802833 C/T cg23711669 chr6:146136114 FBXO30 -0.64 -10.84 -0.51 1.32e-23 Lobe attachment (rater-scored or self-reported); CRC cis rs4332037 0.851 rs34040190 chr7:1920356 G/A cg21155852 chr7:2048760 MAD1L1 -0.52 -6.99 -0.36 1.54e-11 Bipolar disorder; CRC cis rs10751667 0.643 rs12278229 chr11:946985 A/G cg23136738 chr11:925521 AP2A2 -0.39 -6.47 -0.34 3.49e-10 Alzheimer's disease (late onset); CRC cis rs4862750 0.872 rs13143414 chr4:187878213 G/A cg03647317 chr4:187891568 NA -0.53 -10.08 -0.49 5.13e-21 Lobe attachment (rater-scored or self-reported); CRC cis rs4665809 1.000 rs6739061 chr2:26256147 C/T cg27170947 chr2:26402098 FAM59B -0.44 -5.89 -0.31 9.43e-9 Gut microbiome composition (summer); CRC cis rs60843830 1.000 rs55936726 chr2:258210 T/C cg00108164 chr2:264199 ACP1;SH3YL1 0.61 9.64 0.47 1.51e-19 Spherical equivalent (joint analysis main effects and education interaction); CRC cis rs12541335 0.639 rs13257108 chr8:22165043 T/C cg02788857 chr8:22132959 PIWIL2 0.49 8.59 0.43 3.61e-16 Hypertriglyceridemia; CRC cis rs12541335 0.639 rs7003478 chr8:22201123 A/G cg26039829 chr8:22132926 PIWIL2 0.52 9.18 0.45 4.74e-18 Hypertriglyceridemia; CRC cis rs763014 0.966 rs12935215 chr16:670605 T/C cg02475695 chr16:616220 NHLRC4 0.47 7.68 0.39 1.78e-13 Height; CRC cis rs3785574 0.927 rs2854183 chr17:61968002 C/T cg23090583 chr17:61904693 PSMC5;FTSJ3 0.61 8.54 0.43 5.14e-16 Height; CRC cis rs13108904 0.837 rs4591539 chr4:1279938 G/C cg00684032 chr4:1343700 KIAA1530 0.48 7.08 0.36 8.57e-12 Obesity-related traits; CRC cis rs7789940 1.000 rs7789940 chr7:75951230 A/G cg10167463 chr7:75959203 YWHAG -0.76 -10.82 -0.51 1.47e-23 Multiple sclerosis; CRC cis rs826838 0.678 rs11182781 chr12:38610178 C/T cg26384229 chr12:38710491 ALG10B 0.69 9.19 0.45 4.61e-18 Heart rate; CRC cis rs10193935 0.901 rs55978605 chr2:42573402 C/A cg27598129 chr2:42591480 NA -0.67 -7.68 -0.39 1.82e-13 Colonoscopy-negative controls vs population controls; CRC cis rs3741151 0.892 rs77127734 chr11:73018413 T/A cg17517138 chr11:73019481 ARHGEF17 0.68 7.22 0.37 3.52e-12 GIP levels in response to oral glucose tolerance test (120 minutes); CRC cis rs9814567 0.712 rs9838889 chr3:134332311 G/T cg06109529 chr3:134205091 CEP63;ANAPC13 -0.67 -9.58 -0.47 2.53e-19 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs2292884 0.505 rs11889660 chr2:238438395 C/T cg14458575 chr2:238380390 NA 0.72 9.15 0.45 6.25e-18 Prostate cancer; CRC cis rs6681460 0.625 rs2872079 chr1:67130071 G/A cg02459107 chr1:67143332 SGIP1 0.34 6.15 0.32 2.21e-9 Presence of antiphospholipid antibodies; CRC cis rs2302190 0.882 rs12939703 chr17:56611090 G/C cg25885038 chr17:56607967 SEPT4 -0.52 -7.88 -0.4 4.76e-14 Vitamin D levels; CRC cis rs11098499 0.604 rs2389882 chr4:120566733 A/C cg24375607 chr4:120327624 NA 0.49 7.37 0.38 1.37e-12 Corneal astigmatism; CRC cis rs9303401 0.615 rs7502342 chr17:56922629 C/A cg10487724 chr17:56770010 TEX14;RAD51C 0.76 9.53 0.47 3.57e-19 Cognitive test performance; CRC cis rs9311474 0.507 rs4687644 chr3:52746541 T/G cg10802521 chr3:52805072 NEK4 -0.58 -9.05 -0.45 1.31e-17 Electroencephalogram traits; CRC cis rs798554 0.836 rs798502 chr7:2789880 G/T cg13628971 chr7:2884303 GNA12 -0.47 -6.51 -0.34 2.82e-10 Height; CRC trans rs7267979 1.000 rs7268053 chr20:25328286 A/T cg17903999 chr18:56338584 MALT1 0.42 6.98 0.36 1.63e-11 Liver enzyme levels (alkaline phosphatase); CRC cis rs4665809 1.000 rs10048683 chr2:26320519 C/T cg25036284 chr2:26402008 FAM59B -0.46 -6.0 -0.31 5.24e-9 Gut microbiome composition (summer); CRC trans rs11039798 0.764 rs4357721 chr11:48354907 G/A cg03929089 chr4:120376271 NA -0.66 -6.57 -0.34 1.92e-10 Axial length; CRC cis rs12995491 0.731 rs13019346 chr2:88509321 A/G cg24977027 chr2:88469347 THNSL2 -0.33 -5.68 -0.3 3.04e-8 Response to metformin (IC50); CRC cis rs1915146 0.546 rs1715862 chr10:126856255 C/T cg00406319 chr10:126851303 NA -0.4 -5.67 -0.3 3.18e-8 Menarche (age at onset); CRC cis rs1150668 0.699 rs1531681 chr6:28226878 A/G cg25164649 chr6:28176230 NA 0.38 5.67 0.3 3.07e-8 Pubertal anthropometrics; CRC cis rs617791 0.508 rs747526 chr11:65776071 C/A cg27068330 chr11:65405492 SIPA1 -0.48 -6.63 -0.34 1.37e-10 Breast cancer; CRC cis rs9611565 0.512 rs5751153 chr22:42156561 T/C cg17554472 chr22:41940697 POLR3H 0.55 5.65 0.3 3.52e-8 Vitiligo; CRC cis rs4268898 0.516 rs7597149 chr2:24371962 C/T cg06627628 chr2:24431161 ITSN2 0.46 6.9 0.36 2.68e-11 Asthma; CRC cis rs3087591 0.960 rs12603885 chr17:29466722 C/T cg24425628 chr17:29625626 OMG;NF1 0.86 16.19 0.67 8.72e-44 Hip circumference; CRC cis rs10751667 0.666 rs6597962 chr11:976351 C/T cg23136738 chr11:925521 AP2A2 -0.4 -6.66 -0.34 1.14e-10 Alzheimer's disease (late onset); CRC cis rs2576037 0.501 rs7227700 chr18:44537102 T/G cg07643061 chr18:44555308 TCEB3C;TCEB3CL;KATNAL2 -0.35 -5.97 -0.31 6.25e-9 Personality dimensions; CRC cis rs2243480 1.000 rs410128 chr7:65603173 C/T cg18252515 chr7:66147081 NA -1.24 -13.52 -0.6 1.9e-33 Diabetic kidney disease; CRC cis rs796364 0.806 rs74724807 chr2:201005109 A/C cg25936922 chr2:200820526 C2orf60;C2orf47 -0.65 -6.15 -0.32 2.23e-9 Schizophrenia; CRC cis rs7586879 0.616 rs10203386 chr2:25136866 T/A cg22495460 chr2:25135724 ADCY3 -0.98 -20.87 -0.75 3.29e-62 Body mass index; CRC cis rs9322193 0.884 rs11155669 chr6:149954637 T/C cg00933542 chr6:150070202 PCMT1 0.29 6.08 0.32 3.37e-9 Lung cancer; CRC cis rs2303759 0.881 rs10412811 chr19:49884495 G/A cg24324837 chr19:49891574 CCDC155 0.62 8.71 0.43 1.48e-16 Multiple sclerosis; CRC cis rs4927850 0.752 rs7624460 chr3:195748530 C/T cg00031303 chr3:195681400 NA 0.51 7.47 0.38 7.51e-13 Pancreatic cancer; CRC trans rs11098499 0.863 rs3733525 chr4:120447048 A/G cg25214090 chr10:38739885 LOC399744 0.65 10.1 0.49 4.61e-21 Corneal astigmatism; CRC cis rs875971 0.545 rs4718364 chr7:66001340 C/A cg11764359 chr7:65958608 NA 0.46 5.79 0.3 1.6e-8 Aortic root size; CRC cis rs2549003 1.000 rs2549002 chr5:131829578 C/A cg00255919 chr5:131827918 IRF1 -0.63 -12.51 -0.57 1.23e-29 Asthma (sex interaction); CRC trans rs10842750 1.000 rs10842750 chr12:26690565 G/T cg25733613 chr11:111637437 PPP2R1B 0.52 6.29 0.33 1.01e-9 Kashin-Beck disease; CRC cis rs992157 0.767 rs2014615 chr2:219171191 A/G cg04731861 chr2:219085781 ARPC2 -0.3 -6.1 -0.32 2.9e-9 Colorectal cancer; CRC cis rs524281 0.506 rs2298466 chr11:66011280 T/C cg16950941 chr11:66035639 RAB1B -0.5 -6.13 -0.32 2.5e-9 Electroencephalogram traits; CRC trans rs58688157 0.705 rs7112149 chr11:595890 G/A cg19188899 chr13:112838565 NA -0.42 -6.45 -0.34 3.93e-10 Systemic lupus erythematosus; CRC cis rs9323205 0.911 rs60034431 chr14:51622437 C/A cg23942311 chr14:51606299 NA -0.57 -7.01 -0.36 1.36e-11 Cancer; CRC trans rs7615952 0.512 rs2922175 chr3:125361360 T/C cg03844506 chr4:4109441 NA -0.51 -7.57 -0.39 3.88e-13 Blood pressure (smoking interaction); CRC cis rs9660992 0.710 rs1668864 chr1:205248799 T/C cg21643547 chr1:205240462 TMCC2 -0.45 -7.25 -0.37 2.98e-12 Mean corpuscular volume;Mean platelet volume; CRC cis rs10504229 0.683 rs67492041 chr8:58140077 G/A cg21724239 chr8:58056113 NA 0.49 6.81 0.35 4.75e-11 Developmental language disorder (linguistic errors); CRC cis rs1320333 0.772 rs2903491 chr2:686688 T/A cg20966539 chr2:681320 NA 0.65 5.99 0.31 5.42e-9 Obesity-related traits; CRC cis rs1707322 0.963 rs1768815 chr1:46528603 G/A cg03146154 chr1:46216737 IPP -0.51 -6.93 -0.36 2.27e-11 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs10791323 0.582 rs2723613 chr11:133706696 G/A cg03690763 chr11:133734501 NA -0.36 -5.9 -0.31 8.92e-9 Childhood ear infection; CRC cis rs9549367 0.789 rs12584813 chr13:113895443 C/G cg18105134 chr13:113819100 PROZ -0.69 -9.96 -0.48 1.33e-20 Platelet distribution width; CRC cis rs7811142 1.000 rs28490152 chr7:100020982 G/A cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.62 8.4 0.42 1.35e-15 Platelet count; CRC trans rs7726839 0.540 rs72703087 chr5:598029 C/T cg11887960 chr12:57824829 NA 0.59 6.56 0.34 2.05e-10 Obesity-related traits; CRC cis rs4588572 0.601 rs1529500 chr5:77721643 C/T cg11446398 chr5:77624930 NA 0.46 6.33 0.33 7.82e-10 Triglycerides; CRC trans rs2303319 0.504 rs12467613 chr2:162603216 G/T cg22902534 chr3:183892754 AP2M1 -0.7 -6.1 -0.32 2.96e-9 Cognitive function; CRC cis rs9583531 0.689 rs2165418 chr13:111379365 G/T cg24331049 chr13:111365604 ING1 -0.54 -7.15 -0.37 5.63e-12 Coronary artery disease; CRC cis rs524281 0.773 rs10791861 chr11:66008470 G/A cg14036092 chr11:66035641 RAB1B -0.56 -6.35 -0.33 7.22e-10 Electroencephalogram traits; CRC cis rs10971721 0.822 rs12377970 chr9:34021267 T/C cg13495928 chr9:33750294 PRSS3 0.55 5.63 0.3 3.81e-8 Body mass index; CRC cis rs4332037 0.539 rs56180486 chr7:2050747 C/T cg02825527 chr7:2087843 MAD1L1 -0.49 -5.79 -0.3 1.6e-8 Bipolar disorder; CRC cis rs7553864 0.966 rs11161935 chr1:87614191 G/A cg02083836 chr1:87617350 LOC339524 0.35 6.24 0.33 1.36e-9 Smoking behavior; CRC cis rs73206853 0.563 rs9300316 chr12:111196204 T/C cg12870014 chr12:110450643 ANKRD13A 0.66 7.45 0.38 8.19e-13 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC cis rs3741151 0.686 rs12277924 chr11:73219678 T/C cg17517138 chr11:73019481 ARHGEF17 0.55 5.92 0.31 7.97e-9 GIP levels in response to oral glucose tolerance test (120 minutes); CRC cis rs7508679 1.000 rs7508679 chr19:7222832 A/G cg00428638 chr19:7224713 INSR 0.95 19.89 0.74 2.35e-58 Hypothyroidism; CRC cis rs6570726 0.791 rs422099 chr6:145806936 C/T cg23711669 chr6:146136114 FBXO30 0.73 12.59 0.57 6.38e-30 Lobe attachment (rater-scored or self-reported); CRC cis rs12580194 0.556 rs11171433 chr12:55757797 A/T cg23425280 chr12:56401806 NA 0.47 5.78 0.3 1.76e-8 Cancer; CRC cis rs7605827 0.897 rs34191114 chr2:15670691 C/A cg19274914 chr2:15703543 NA 0.39 5.84 0.31 1.23e-8 Educational attainment (years of education); CRC trans rs116095464 0.558 rs10065584 chr5:253997 G/A cg00938859 chr5:1591904 SDHAP3 0.66 6.07 0.32 3.52e-9 Breast cancer; CRC cis rs7591163 1.000 rs2396499 chr2:228724368 C/T cg14646075 chr2:228736089 WDR69 0.42 5.6 0.3 4.45e-8 Blood pressure; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg13148469 chr1:28969864 TAF12 -0.41 -6.12 -0.32 2.67e-9 Myopia (pathological); CRC cis rs12995491 0.731 rs13019346 chr2:88509321 A/G cg14558114 chr2:88469736 THNSL2 -0.42 -6.23 -0.32 1.46e-9 Response to metformin (IC50); CRC cis rs9467711 0.591 rs35902160 chr6:26128538 C/G cg19084075 chr6:26124329 HIST1H2AC;HIST1H2BC 0.66 6.03 0.32 4.49e-9 Autism spectrum disorder or schizophrenia; CRC cis rs7659604 0.676 rs4077102 chr4:122699830 A/G cg19748678 chr4:122722346 EXOSC9 0.69 11.07 0.52 1.98e-24 Type 2 diabetes; CRC cis rs743757 0.697 rs763030 chr3:50528092 G/C cg08207895 chr3:50388901 TUSC4;CYB561D2 0.43 5.79 0.3 1.65e-8 Diastolic blood pressure; CRC cis rs4731207 0.596 rs1481343 chr7:124652271 T/C cg23710748 chr7:124431027 NA -0.39 -6.25 -0.33 1.24e-9 Cutaneous malignant melanoma; CRC cis rs7615952 0.641 rs60839048 chr3:125807938 G/A cg05084668 chr3:125655381 ALG1L -0.46 -6.58 -0.34 1.91e-10 Blood pressure (smoking interaction); CRC trans rs17331304 0.516 rs13114953 chr4:12188297 A/G cg17170088 chr8:145159375 SHARPIN;MAF1 0.45 6.11 0.32 2.8e-9 Positive affect; CRC cis rs16973500 0.808 rs1049794 chr16:71950450 C/T cg00732059 chr16:71740210 PHLPP2 -0.67 -6.89 -0.36 2.77e-11 Response to anti-TNF therapy in rheumatoid arthritis;Attention deficit hyperactivity disorder and conduct disorder; CRC cis rs1881797 1.000 rs1881797 chr1:247689532 A/G cg05639522 chr1:247681581 NA 0.52 8.86 0.44 5.15e-17 Acute lymphoblastic leukemia (childhood); CRC cis rs6951245 0.872 rs113119264 chr7:1080564 G/A cg04025307 chr7:1156635 C7orf50 0.64 6.76 0.35 6.29e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs9322193 0.884 rs9688858 chr6:149959047 C/A cg07701084 chr6:150067640 NUP43 0.47 6.64 0.34 1.32e-10 Lung cancer; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg04389328 chr22:20104991 RANBP1;TRMT2A 0.39 6.18 0.32 1.93e-9 Liver disease severity in Alagille syndrome; CRC cis rs67311347 0.956 rs9817233 chr3:40425618 G/T cg09455208 chr3:40491958 NA 0.48 9.22 0.45 3.54e-18 Renal cell carcinoma; CRC trans rs9329221 0.905 rs28712068 chr8:10251145 G/C cg08975724 chr8:8085496 FLJ10661 -0.44 -6.85 -0.35 3.69e-11 Neuroticism; CRC cis rs4481887 0.893 rs4512685 chr1:248446246 C/T cg00666640 chr1:248458726 OR2T12 0.54 9.7 0.47 1.01e-19 Common traits (Other); CRC cis rs10504229 0.595 rs79077737 chr8:58117520 G/A cg21724239 chr8:58056113 NA 0.52 7.09 0.36 8.04e-12 Developmental language disorder (linguistic errors); CRC trans rs7618501 1.000 rs1491986 chr3:49739086 C/T cg21665057 chr3:196295764 WDR53;FBXO45 -0.86 -16.09 -0.66 2.26e-43 Intelligence (multi-trait analysis); CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg06423533 chr19:4909366 UHRF1 0.48 6.61 0.34 1.59e-10 Anxiety disorder; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg13450310 chr1:39874390 KIAA0754;MACF1 0.41 6.3 0.33 9.71e-10 Response to antipsychotic treatment; CRC cis rs7617773 0.780 rs13081169 chr3:48356797 G/A cg11946769 chr3:48343235 NME6 0.73 9.79 0.47 4.96e-20 Coronary artery disease; CRC cis rs739401 0.566 rs7931504 chr11:3026712 C/T cg25174290 chr11:3078921 CARS 0.48 7.43 0.38 9.72e-13 Longevity; CRC cis rs10504229 0.775 rs72650869 chr8:58157923 T/A cg02290350 chr8:58132656 NA -0.51 -6.39 -0.33 5.68e-10 Developmental language disorder (linguistic errors); CRC cis rs2032447 0.966 rs9358901 chr6:26024436 G/T cg12588279 chr6:26043732 HIST1H2BB 0.45 6.73 0.35 7.47e-11 Intelligence (multi-trait analysis); CRC cis rs9660180 0.967 rs12044597 chr1:1708801 A/G cg13866156 chr1:1669148 SLC35E2 -0.62 -9.59 -0.47 2.35e-19 Body mass index; CRC trans rs1973993 0.691 rs4000303 chr1:96913765 A/G cg10631902 chr5:14652156 NA 0.62 12.41 0.56 2.9e-29 Weight; CRC cis rs3733585 0.578 rs4466042 chr4:9955367 T/C cg00071950 chr4:10020882 SLC2A9 -0.55 -9.78 -0.47 5.18e-20 Cleft plate (environmental tobacco smoke interaction); CRC cis rs2228479 0.717 rs1800358 chr16:89809319 T/C cg19635926 chr16:89946313 TCF25 0.57 5.96 0.31 6.58e-9 Skin colour saturation; CRC cis rs853679 0.517 rs9468286 chr6:28079428 C/T cg25164649 chr6:28176230 NA 0.77 9.5 0.46 4.6e-19 Depression; CRC cis rs2806561 0.765 rs668234 chr1:23515467 G/A cg12483005 chr1:23474871 LUZP1 0.49 7.15 0.37 5.58e-12 Height; CRC cis rs13256369 1.000 rs10103769 chr8:8573036 G/T cg18904891 chr8:8559673 CLDN23 0.49 6.53 0.34 2.53e-10 Obesity-related traits; CRC cis rs9467773 0.620 rs2101582 chr6:26622734 C/T cg09904177 chr6:26538194 HMGN4 0.72 11.63 0.54 1.97e-26 Intelligence (multi-trait analysis); CRC cis rs7829975 0.742 rs1533058 chr8:8685190 A/G cg06636001 chr8:8085503 FLJ10661 0.55 8.22 0.41 4.66e-15 Mood instability; CRC cis rs2276314 0.553 rs1789501 chr18:33617060 T/A cg19628046 chr18:33552617 C18orf21 -0.4 -6.23 -0.32 1.4e-9 Endometriosis;Drug-induced torsades de pointes; CRC cis rs11971779 0.680 rs10265718 chr7:139100068 G/A cg23387468 chr7:139079360 LUC7L2 0.41 7.05 0.36 1.04e-11 Diisocyanate-induced asthma; CRC cis rs995000 0.868 rs880694 chr1:63173284 C/T cg19896129 chr1:63156450 NA -0.44 -6.79 -0.35 5.09e-11 Triglyceride levels; CRC cis rs6499255 0.951 rs7186002 chr16:69751065 C/G cg15192750 chr16:69999425 NA 0.54 7.1 0.36 7.55e-12 IgE levels; CRC cis rs6831352 0.918 rs17218141 chr4:100055908 T/C cg12011299 chr4:100065546 ADH4 -0.49 -9.27 -0.45 2.61e-18 Alcohol dependence; CRC cis rs7811142 0.779 rs111312383 chr7:99905325 C/T cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.88 11.05 0.52 2.28e-24 Platelet count; CRC cis rs875971 0.597 rs11763224 chr7:65983615 G/T cg11764359 chr7:65958608 NA 0.46 5.71 0.3 2.57e-8 Aortic root size; CRC cis rs4970988 0.556 rs6695123 chr1:150563483 T/C cg17724175 chr1:150552817 MCL1 -0.67 -11.23 -0.53 5.55e-25 Urate levels; CRC cis rs5753618 0.561 rs5749265 chr22:31796897 A/C cg07713946 chr22:31675144 LIMK2 0.41 6.19 0.32 1.81e-9 Colorectal cancer; CRC cis rs2404602 0.647 rs907593 chr15:77196953 G/A cg03037974 chr15:76606532 NA -0.52 -7.17 -0.37 5e-12 Blood metabolite levels; CRC cis rs6952808 1.000 rs6953693 chr7:1886388 C/G cg21782813 chr7:2030301 MAD1L1 0.41 7.13 0.37 6.55e-12 Bipolar disorder and schizophrenia; CRC cis rs9488822 0.676 rs11153594 chr6:116354591 A/G cg15226275 chr6:116381976 FRK -0.31 -8.89 -0.44 4.08e-17 Cholesterol, total;LDL cholesterol; CRC cis rs9303401 0.659 rs34426768 chr17:56683385 C/T cg10487724 chr17:56770010 TEX14;RAD51C 0.8 9.19 0.45 4.41e-18 Cognitive test performance; CRC cis rs523522 0.926 rs10849766 chr12:121025894 G/A cg27279351 chr12:120934652 DYNLL1 0.74 10.54 0.5 1.46e-22 High light scatter reticulocyte count; CRC cis rs7746199 0.736 rs6904596 chr6:27491299 G/A cg26587870 chr6:27730563 NA -0.63 -5.88 -0.31 9.85e-9 Gait speed in old age;Autism spectrum disorder or schizophrenia; CRC cis rs4843747 0.749 rs72818535 chr16:88074039 G/A cg03395651 chr16:88107091 BANP 0.55 7.29 0.37 2.31e-12 Menopause (age at onset); CRC cis rs6088590 0.735 rs6088618 chr20:33409350 G/A cg08999081 chr20:33150536 PIGU 0.55 10.13 0.49 3.53e-21 Coronary artery disease; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg21257117 chr11:65029643 POLA2 0.47 6.04 0.32 4.21e-9 Thyroid stimulating hormone; CRC cis rs9467711 0.591 rs17586553 chr6:25928775 C/T cg08501292 chr6:25962987 TRIM38 1.06 9.73 0.47 7.93e-20 Autism spectrum disorder or schizophrenia; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg14475554 chr1:209799191 LAMB3 0.4 6.07 0.32 3.61e-9 Myopia (pathological); CRC cis rs9403521 1.000 rs12208927 chr6:143993634 A/G cg18240653 chr6:144019428 PHACTR2 -0.54 -5.98 -0.31 5.94e-9 Obesity-related traits; CRC cis rs2456568 0.802 rs1395387 chr11:93639307 A/T cg26875233 chr11:93583750 C11orf90 -0.33 -6.35 -0.33 7.28e-10 Response to serotonin reuptake inhibitors in major depressive disorder; CRC cis rs2836974 0.644 rs4818017 chr21:40690561 G/T cg11644478 chr21:40555479 PSMG1 -0.62 -9.5 -0.46 4.66e-19 Cognitive function; CRC trans rs3942852 0.568 rs10769314 chr11:48097620 C/T cg03929089 chr4:120376271 NA -0.6 -8.23 -0.41 4.37e-15 Acute lymphoblastic leukemia (childhood); CRC cis rs4285028 0.948 rs2877560 chr3:121699238 C/A cg11130432 chr3:121712080 ILDR1 -0.52 -6.81 -0.35 4.73e-11 Multiple sclerosis; CRC cis rs875971 0.619 rs10278371 chr7:66051540 C/A cg25985355 chr7:65971099 NA 0.33 5.83 0.31 1.33e-8 Aortic root size; CRC cis rs12188164 0.965 rs1056465 chr5:442438 T/A cg26850624 chr5:429559 AHRR -0.8 -13.45 -0.6 3.5e-33 Cystic fibrosis severity; CRC cis rs10256972 0.621 rs10951594 chr7:1088607 C/G cg16145915 chr7:1198662 ZFAND2A -0.33 -6.53 -0.34 2.44e-10 Longevity;Endometriosis; CRC cis rs990171 1.000 rs917997 chr2:103070568 T/C cg03938978 chr2:103052716 IL18RAP 0.46 5.89 0.31 9.34e-9 Lymphocyte counts; CRC cis rs7945705 0.738 rs11042067 chr11:8815453 T/C cg12365402 chr11:9010492 NRIP3 -0.38 -6.47 -0.34 3.47e-10 Hemoglobin concentration; CRC cis rs7020830 1.000 rs7020830 chr9:37085184 A/T cg14294708 chr9:37120828 ZCCHC7 1.1 22.73 0.78 1.94e-69 Schizophrenia; CRC trans rs61931739 0.500 rs11053269 chr12:34545307 A/G cg26384229 chr12:38710491 ALG10B 0.59 8.77 0.44 9.64e-17 Morning vs. evening chronotype; CRC cis rs2354432 0.825 rs10900347 chr1:146800107 G/C cg25205988 chr1:146714368 CHD1L 1.18 14.67 0.63 7.58e-38 Mitochondrial DNA levels; CRC cis rs7587476 0.906 rs17487827 chr2:215644335 C/G cg04004882 chr2:215674386 BARD1 0.62 7.74 0.39 1.25e-13 Neuroblastoma; CRC cis rs7394190 0.748 rs78790589 chr10:75539598 G/A cg07699608 chr10:75541558 CHCHD1 0.69 6.89 0.36 2.79e-11 Incident atrial fibrillation; CRC cis rs72387598 1 rs72387598 chr1:45922977 CAT/C cg05343316 chr1:45956843 TESK2 0.76 10.17 0.49 2.73e-21 Platelet distribution width; CRC cis rs4713118 0.662 rs13218430 chr6:28029837 T/C cg25164649 chr6:28176230 NA 0.65 8.58 0.43 3.87e-16 Parkinson's disease; CRC cis rs9398803 0.865 rs9388494 chr6:126776094 G/T cg19875578 chr6:126661172 C6orf173 0.43 5.9 0.31 9.18e-9 Male-pattern baldness; CRC trans rs7618501 0.633 rs6792892 chr3:49995518 T/C cg21665057 chr3:196295764 WDR53;FBXO45 0.61 9.53 0.47 3.56e-19 Intelligence (multi-trait analysis); CRC cis rs4604732 0.631 rs4411161 chr1:247632374 G/A cg02104434 chr1:247694406 LOC148824;OR2C3 0.55 8.22 0.41 4.87e-15 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CRC cis rs7762018 1.000 rs6459657 chr6:170136454 A/G cg19338460 chr6:170058176 WDR27 -0.71 -7.8 -0.4 8.04e-14 Thiazide-induced adverse metabolic effects in hypertensive patients; CRC cis rs4319547 1.000 rs10998 chr12:122989412 G/A cg23029597 chr12:123009494 RSRC2 -0.65 -8.05 -0.41 1.51e-14 Body mass index; CRC cis rs6860806 0.661 rs4705927 chr5:131578608 C/G cg11843238 chr5:131593191 PDLIM4 0.43 8.44 0.42 9.92e-16 Breast cancer; CRC cis rs9905704 0.918 rs302852 chr17:56685214 C/T cg12560992 chr17:57184187 TRIM37 0.56 7.64 0.39 2.46e-13 Testicular germ cell tumor; CRC cis rs394563 0.967 rs447025 chr6:149799128 A/C cg11245181 chr6:149772854 ZC3H12D -0.53 -8.98 -0.44 2.14e-17 Dupuytren's disease; CRC cis rs1552172 0.853 rs2018027 chr1:145595820 A/G cg11743829 chr1:145714124 CD160 0.37 5.87 0.31 1.04e-8 Breast cancer; CRC cis rs10504229 0.728 rs17804720 chr8:58154565 T/C cg21724239 chr8:58056113 NA 0.62 8.38 0.42 1.51e-15 Developmental language disorder (linguistic errors); CRC cis rs853679 0.517 rs9368557 chr6:28131537 T/C cg21251018 chr6:28226885 NKAPL 0.48 6.17 0.32 2.02e-9 Depression; CRC cis rs9660180 0.967 rs6664664 chr1:1751264 G/A cg03396347 chr1:1875803 NA -0.6 -9.34 -0.46 1.53e-18 Body mass index; CRC cis rs7772486 0.754 rs9373476 chr6:146139741 C/G cg23711669 chr6:146136114 FBXO30 0.73 12.61 0.57 5.41e-30 Lobe attachment (rater-scored or self-reported); CRC cis rs10504229 0.683 rs72650839 chr8:58130029 C/T cg21724239 chr8:58056113 NA 0.49 6.81 0.35 4.75e-11 Developmental language disorder (linguistic errors); CRC cis rs11098499 0.866 rs12510451 chr4:120289143 C/T cg09307838 chr4:120376055 NA 0.68 10.53 0.5 1.51e-22 Corneal astigmatism; CRC cis rs1552244 0.938 rs7625049 chr3:10115619 C/T cg08888203 chr3:10149979 C3orf24 0.7 10.01 0.48 8.99e-21 Alzheimer's disease; CRC cis rs1451375 0.698 rs1839740 chr7:50646280 C/T cg18232548 chr7:50535776 DDC 0.44 6.25 0.33 1.24e-9 Malaria; CRC cis rs1030877 0.521 rs2576747 chr2:105978676 A/T cg02079111 chr2:105885981 TGFBRAP1 0.49 7.69 0.39 1.74e-13 Obesity-related traits; CRC cis rs1008375 0.897 rs1006723 chr4:17618524 G/A cg02297831 chr4:17616191 MED28 0.45 5.98 0.31 5.89e-9 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs3736485 0.934 rs4143723 chr15:51867172 A/G cg08986416 chr15:51914746 DMXL2 -0.46 -6.64 -0.34 1.29e-10 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs853679 0.517 rs3757185 chr6:28107776 T/A cg18032046 chr6:28092343 ZSCAN16 -0.52 -6.08 -0.32 3.3e-9 Depression; CRC cis rs933688 1.000 rs332544 chr5:90778848 C/T cg02339078 chr5:90679543 LOC100129716;ARRDC3 0.85 14.98 0.64 4.77e-39 Smoking behavior; CRC trans rs7824557 0.527 rs4634600 chr8:11239017 T/A cg06636001 chr8:8085503 FLJ10661 -0.44 -6.54 -0.34 2.31e-10 Retinal vascular caliber; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg01164326 chr16:66460784 BEAN 0.43 6.93 0.36 2.23e-11 Liver disease severity in Alagille syndrome; CRC cis rs208520 0.739 rs1935894 chr6:66891434 A/G cg07460842 chr6:66804631 NA -0.93 -12.55 -0.57 8.48e-30 Exhaled nitric oxide output; CRC trans rs7824557 0.547 rs2409745 chr8:11076635 G/T cg06636001 chr8:8085503 FLJ10661 0.57 8.61 0.43 3.06e-16 Retinal vascular caliber; CRC cis rs10927875 1.000 rs3979179 chr1:16306846 A/G cg22431228 chr1:16359049 CLCNKA -0.33 -5.68 -0.3 3e-8 Dilated cardiomyopathy; CRC trans rs6462411 0.646 rs10273444 chr7:3923414 A/G cg24598187 chr5:96253798 ERAP2 -0.5 -6.01 -0.31 4.98e-9 Quantitative traits; CRC cis rs801193 1.000 rs2659906 chr7:66165310 T/C cg18876405 chr7:65276391 NA 0.61 10.76 0.51 2.53e-23 Aortic root size; CRC cis rs780096 0.565 rs8179252 chr2:27746832 A/C cg02592271 chr2:27665507 KRTCAP3 -0.26 -5.83 -0.31 1.33e-8 Total body bone mineral density; CRC trans rs11722228 0.522 rs12504600 chr4:10067138 C/A cg26043149 chr18:55253948 FECH 1.13 17.53 0.69 4.94e-49 Gout;Urate levels;Serum uric acid levels; CRC cis rs3087591 0.810 rs2269856 chr17:29482701 C/T cg24425628 chr17:29625626 OMG;NF1 0.8 13.75 0.6 2.71e-34 Hip circumference; CRC cis rs9322193 0.962 rs10214845 chr6:150104260 A/G cg05861140 chr6:150128134 PCMT1 -0.43 -7.05 -0.36 1.03e-11 Lung cancer; CRC trans rs2303319 0.504 rs56009150 chr2:162598582 T/C cg08132177 chr1:856685 NA -0.68 -6.0 -0.31 5.29e-9 Cognitive function; CRC cis rs9682041 0.561 rs6444928 chr3:170147875 A/G cg11886554 chr3:170076028 SKIL 0.63 7.02 0.36 1.24e-11 Glomerular filtration rate in non diabetics (creatinine);Glomerular filtration rate (creatinine); CRC trans rs2228479 0.557 rs34420680 chr16:89809171 C/T cg24644049 chr4:85504048 CDS1 0.93 7.5 0.38 5.89e-13 Skin colour saturation; CRC cis rs8062405 0.720 rs9926245 chr16:28555706 T/A cg05139728 chr16:28306816 SBK1 -0.34 -5.79 -0.3 1.62e-8 Cognitive ability (multi-trait analysis);Cognitive ability; CRC cis rs798554 0.660 rs798480 chr7:2805597 G/T cg13628971 chr7:2884303 GNA12 0.38 5.61 0.3 4.25e-8 Height; CRC cis rs2228479 0.702 rs11646374 chr16:89857935 G/A cg06558623 chr16:89946397 TCF25 1.16 11.41 0.53 1.27e-25 Skin colour saturation; CRC cis rs4654899 0.812 rs7539512 chr1:21410791 A/G cg02927042 chr1:21476669 EIF4G3 -0.41 -6.53 -0.34 2.54e-10 Superior frontal gyrus grey matter volume; CRC cis rs11997175 0.624 rs6996590 chr8:33680486 A/G cg04338863 chr8:33670619 NA 0.44 7.06 0.36 9.65e-12 Body mass index; CRC cis rs7827545 0.960 rs1372661 chr8:135566859 A/G cg13086574 chr8:135490821 ZFAT -0.37 -6.26 -0.33 1.19e-9 Hypertension (SNP x SNP interaction); CRC cis rs4713118 0.513 rs149878 chr6:27878738 T/G cg06470822 chr6:28175283 NA 0.81 12.15 0.56 2.52e-28 Parkinson's disease; CRC cis rs539514 0.587 rs9530466 chr13:76323774 T/C cg04757411 chr13:76259545 LMO7 -0.37 -5.84 -0.31 1.24e-8 Type 1 diabetes; CRC cis rs10504229 1.000 rs56740825 chr8:58175617 A/G cg02725872 chr8:58115012 NA -0.38 -6.43 -0.33 4.44e-10 Developmental language disorder (linguistic errors); CRC cis rs2228479 0.850 rs45524643 chr16:89815824 G/A cg06558623 chr16:89946397 TCF25 1.15 10.8 0.51 1.85e-23 Skin colour saturation; CRC cis rs12701220 0.503 rs13222294 chr7:1172969 G/A cg02733842 chr7:1102375 C7orf50 -0.76 -9.35 -0.46 1.41e-18 Bronchopulmonary dysplasia; CRC cis rs6662572 0.686 rs72692639 chr1:46446096 A/G cg08644498 chr1:46502608 NA 0.46 7.09 0.36 8.14e-12 Blood protein levels; CRC cis rs4400599 0.772 rs4579747 chr1:154153106 A/G cg05139571 chr1:154127138 NUP210L 0.42 6.27 0.33 1.12e-9 Platelet distribution width; CRC cis rs9611565 0.659 rs12484175 chr22:41953739 A/C cg03806693 chr22:41940476 POLR3H -1.15 -15.81 -0.66 2.72e-42 Vitiligo; CRC cis rs2408955 0.504 rs11168441 chr12:48576054 G/A cg21466736 chr12:48725269 NA -0.51 -7.61 -0.39 2.93e-13 Glycated hemoglobin levels; CRC cis rs2624839 0.704 rs12637671 chr3:50224562 G/A cg24110177 chr3:50126178 RBM5 0.42 5.78 0.3 1.7e-8 Intelligence (multi-trait analysis); CRC trans rs948562 0.947 rs17489568 chr11:58390007 C/G cg26660744 chr1:1573181 CDK11B 0.54 6.1 0.32 2.94e-9 Lymphoma; CRC cis rs4481887 0.861 rs4575112 chr1:248473534 A/G cg00666640 chr1:248458726 OR2T12 0.45 7.8 0.4 8.31e-14 Common traits (Other); CRC cis rs6963495 0.818 rs6973974 chr7:105170629 C/T cg02135003 chr7:105160482 PUS7 -0.92 -12.46 -0.57 1.94e-29 Bipolar disorder (body mass index interaction); CRC cis rs4819052 0.851 rs4819049 chr21:46673086 C/G cg02159808 chr21:46707872 POFUT2;LOC642852 0.52 6.91 0.36 2.59e-11 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs8114671 0.562 rs4911450 chr20:33512406 C/T cg07148914 chr20:33460835 GGT7 0.44 7.05 0.36 1.03e-11 Height; CRC cis rs10979 0.931 rs12191837 chr6:143898200 T/G cg25407410 chr6:143891975 LOC285740 -0.84 -13.85 -0.61 1.12e-34 Hypospadias; CRC cis rs7044106 0.708 rs959558 chr9:123368911 C/G cg09419670 chr9:123605666 PSMD5;LOC253039 0.64 10.39 0.5 4.71e-22 Hip circumference adjusted for BMI; CRC cis rs4285028 0.948 rs34566912 chr3:121679626 G/A cg11130432 chr3:121712080 ILDR1 -0.48 -6.22 -0.32 1.48e-9 Multiple sclerosis; CRC cis rs2267708 0.509 rs6959972 chr7:124617108 T/C cg23710748 chr7:124431027 NA -0.39 -6.17 -0.32 1.96e-9 Chronic lymphocytic leukemia; CRC cis rs1524976 1.000 rs62255282 chr3:65485422 C/T cg16238336 chr3:65465873 MAGI1 -0.54 -6.91 -0.36 2.45e-11 PR interval; CRC cis rs7072216 0.763 rs6584202 chr10:100170383 G/A cg26618903 chr10:100175079 PYROXD2 -0.52 -8.65 -0.43 2.34e-16 Metabolite levels; CRC cis rs7927771 1.000 rs11039255 chr11:47495746 G/T cg20307385 chr11:47447363 PSMC3 -0.58 -8.09 -0.41 1.14e-14 Subjective well-being; CRC cis rs13256369 0.901 rs12681327 chr8:8566414 G/T cg00074818 chr8:8560427 CLDN23 0.4 6.99 0.36 1.58e-11 Obesity-related traits; CRC cis rs4132509 0.948 rs12048930 chr1:243940076 C/T cg21452805 chr1:244014465 NA 0.54 7.26 0.37 2.77e-12 RR interval (heart rate); CRC cis rs1816752 0.905 rs7571 chr13:25000617 C/G cg02811702 chr13:24901961 NA 0.45 6.22 0.32 1.53e-9 Obesity-related traits; CRC cis rs7680126 0.596 rs4698031 chr4:10315921 A/G cg11266682 chr4:10021025 SLC2A9 -0.4 -6.04 -0.32 4.17e-9 Urate levels in lean individuals;Urate levels in overweight individuals;Urate levels in obese individuals; CRC cis rs2370759 1.000 rs11594459 chr10:32561858 A/C cg01819863 chr10:32635814 EPC1 1.1 12.56 0.57 7.89e-30 Sexual dysfunction (female); CRC cis rs394563 0.690 rs237009 chr6:149759552 C/T cg11245181 chr6:149772854 ZC3H12D -0.6 -10.52 -0.5 1.65e-22 Dupuytren's disease; CRC cis rs8114671 0.562 rs2378294 chr20:33500378 G/A cg07148914 chr20:33460835 GGT7 0.4 6.5 0.34 3.02e-10 Height; CRC cis rs11971779 0.584 rs34762928 chr7:139113168 T/A cg07862535 chr7:139043722 LUC7L2 0.57 7.35 0.38 1.61e-12 Diisocyanate-induced asthma; CRC cis rs1552244 0.938 rs7652951 chr3:10063763 A/C cg02579736 chr3:10068473 FANCD2;CIDECP 0.95 12.63 0.57 4.38e-30 Alzheimer's disease; CRC trans rs7395662 0.784 rs79037165 chr11:48865464 G/T cg21153622 chr11:89784906 NA 0.46 7.34 0.38 1.68e-12 HDL cholesterol; CRC cis rs9372498 0.536 rs62422220 chr6:118923731 G/A cg15382696 chr6:118971807 C6orf204 0.61 7.77 0.39 1.01e-13 Diastolic blood pressure; CRC cis rs67311347 1.000 rs6599094 chr3:40399593 A/G cg24209194 chr3:40518798 ZNF619 0.42 6.43 0.33 4.54e-10 Renal cell carcinoma; CRC cis rs12477438 0.700 rs10190421 chr2:99670711 C/T cg14399236 chr2:99771627 LIPT1;TSGA10 -0.74 -10.37 -0.5 5.51e-22 Chronic sinus infection; CRC cis rs977987 0.843 rs67409275 chr16:75457212 T/C cg03315344 chr16:75512273 CHST6 0.52 8.82 0.44 6.77e-17 Dupuytren's disease; CRC cis rs933688 0.938 rs7708782 chr5:90718517 T/C cg02339078 chr5:90679543 LOC100129716;ARRDC3 0.92 13.87 0.61 9.28e-35 Smoking behavior; CRC trans rs3780486 0.846 rs10971419 chr9:33124161 T/C cg20290983 chr6:43655470 MRPS18A 1.16 26.9 0.83 4.44e-85 IgG glycosylation; CRC trans rs7267979 0.816 rs6115094 chr20:25210827 A/G cg17903999 chr18:56338584 MALT1 -0.39 -6.23 -0.32 1.44e-9 Liver enzyme levels (alkaline phosphatase); CRC trans rs10983614 1.000 rs7867776 chr9:120072627 A/G cg26297968 chr2:211035960 C2orf67 0.46 6.32 0.33 8.73e-10 Survival in pancreatic cancer; CRC cis rs28386778 0.830 rs2665841 chr17:61861219 A/T cg25654072 chr17:61904446 PSMC5;FTSJ3 0.74 11.57 0.54 3.39e-26 Prudent dietary pattern; CRC cis rs2302729 0.578 rs10774052 chr12:2772171 C/T cg19945202 chr12:2788847 CACNA1C -0.44 -6.99 -0.36 1.54e-11 Sleep quality; CRC cis rs364477 0.904 rs279898 chr9:965191 C/T cg13952963 chr9:998547 NA 0.57 6.07 0.32 3.53e-9 Major depressive disorder; CRC cis rs7493 1.000 rs17876124 chr7:95045258 C/G cg21856205 chr7:94953877 PON1 -0.48 -6.28 -0.33 1.1e-9 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs6964587 1.000 rs10234290 chr7:91716951 T/C cg17063962 chr7:91808500 NA 0.8 14.42 0.62 6.98e-37 Breast cancer; CRC cis rs2180341 0.538 rs4577822 chr6:127712911 T/G cg27446573 chr6:127587934 RNF146 0.48 6.98 0.36 1.68e-11 Breast cancer; CRC cis rs274567 0.501 rs2631368 chr5:131705297 T/G cg09877947 chr5:131593287 PDLIM4 -0.45 -7.47 -0.38 7.26e-13 Blood metabolite levels; CRC cis rs6942756 0.774 rs891545 chr7:128866616 A/C cg02491457 chr7:128862824 NA 0.64 9.01 0.44 1.74e-17 White matter hyperintensity burden; CRC cis rs10540 1.000 rs79808876 chr11:465763 C/A cg03352830 chr11:487213 PTDSS2 0.68 7.98 0.4 2.44e-14 Body mass index; CRC cis rs1799949 1.000 rs1799966 chr17:41223094 T/C cg19454999 chr17:41278357 BRCA1;NBR2 0.54 8.49 0.42 6.96e-16 Menopause (age at onset); CRC cis rs72945132 0.882 rs4261311 chr11:70132902 C/T cg14191688 chr11:70257035 CTTN 0.4 5.62 0.3 4.07e-8 Coronary artery disease; CRC cis rs9329289 0.603 rs2458698 chr10:2548452 C/T cg15501526 chr10:2543763 NA 0.68 12.66 0.57 3.27e-30 Age-related hearing impairment; CRC cis rs79387448 0.745 rs17027413 chr2:103153667 A/G cg09003973 chr2:102972529 NA -0.73 -8.06 -0.41 1.38e-14 Gut microbiota (bacterial taxa); CRC cis rs6460942 1.000 rs62448562 chr7:12398785 T/C cg20607287 chr7:12443886 VWDE -0.66 -6.41 -0.33 5.17e-10 Coronary artery disease; CRC cis rs25645 0.502 rs8065126 chr17:38099035 C/T cg17467752 chr17:38218738 THRA -0.4 -5.65 -0.3 3.47e-8 Myeloid white cell count; CRC cis rs4713118 0.662 rs9393881 chr6:28023751 C/G cg25164649 chr6:28176230 NA 0.61 7.93 0.4 3.36e-14 Parkinson's disease; CRC cis rs644799 0.672 rs11021307 chr11:95501407 C/T cg25478527 chr11:95522999 CEP57;FAM76B 0.49 7.49 0.38 6.2800000000000005e-13 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs67311347 1.000 rs7642552 chr3:40424816 T/C cg09455208 chr3:40491958 NA 0.44 8.9 0.44 3.72e-17 Renal cell carcinoma; CRC cis rs9522267 0.535 rs4773392 chr13:112227358 A/G cg10483660 chr13:112241077 NA 0.46 8.78 0.44 8.85e-17 Hepatitis; CRC cis rs9296404 1 rs9296404 chr6:42925803 T/C cg21280719 chr6:42927975 GNMT -0.46 -10.31 -0.49 8.47e-22 Plasma homocysteine levels (post-methionine load test); CRC cis rs7586879 1.000 rs12713419 chr2:25121853 G/A cg04586622 chr2:25135609 ADCY3 -0.52 -8.85 -0.44 5.55e-17 Body mass index; CRC cis rs1577917 0.839 rs1596990 chr6:86550692 C/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.44 -5.78 -0.3 1.75e-8 Response to antipsychotic treatment; CRC trans rs3923380 0.683 rs10004356 chr4:77465025 A/G cg04105282 chr10:99790170 CRTAC1 0.35 6.11 0.32 2.85e-9 Craniofacial microsomia; CRC cis rs7705042 0.865 rs6863411 chr5:141513204 A/T cg08523384 chr5:141488047 NDFIP1 -0.32 -5.76 -0.3 1.91e-8 Asthma; CRC cis rs2832191 0.720 rs4643617 chr21:30485278 T/C cg08807101 chr21:30365312 RNF160 -0.65 -10.67 -0.51 5.23e-23 Dental caries; CRC cis rs9457247 0.935 rs1187530 chr6:167376812 C/T cg23791538 chr6:167370224 RNASET2 0.39 6.09 0.32 3.22e-9 Crohn's disease; CRC cis rs1348850 0.645 rs10164417 chr2:178444130 A/G cg27490568 chr2:178487706 NA 0.43 5.81 0.31 1.48e-8 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs6681460 0.634 rs12143964 chr1:67010266 T/G cg02459107 chr1:67143332 SGIP1 0.35 5.6 0.3 4.43e-8 Presence of antiphospholipid antibodies; CRC cis rs3736485 0.966 rs11070860 chr15:51892654 G/A cg08986416 chr15:51914746 DMXL2 -0.46 -6.47 -0.34 3.56e-10 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs977987 0.624 rs59867374 chr16:75432682 G/A cg03315344 chr16:75512273 CHST6 0.54 9.04 0.45 1.36e-17 Dupuytren's disease; CRC cis rs116095464 0.558 rs6555052 chr5:224268 G/A cg22857025 chr5:266934 NA -1.22 -16.66 -0.68 1.26e-45 Breast cancer; CRC trans rs8073060 0.963 rs11080353 chr17:33871281 C/T cg19694781 chr19:47549865 TMEM160 0.55 8.13 0.41 9.09e-15 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; CRC cis rs9372498 0.536 rs9489452 chr6:118910868 G/C cg15382696 chr6:118971807 C6orf204 0.61 7.95 0.4 3.01e-14 Diastolic blood pressure; CRC cis rs2415984 0.579 rs2642103 chr14:46963280 C/T cg14871534 chr14:47121158 RPL10L 0.4 6.0 0.31 5.12e-9 Number of children ever born; CRC cis rs853679 0.546 rs200996 chr6:27811828 G/A cg08798685 chr6:27730294 NA -0.62 -6.06 -0.32 3.82e-9 Depression; CRC cis rs11098499 0.754 rs10006259 chr4:120242145 C/T cg09307838 chr4:120376055 NA 0.62 9.71 0.47 9.4e-20 Corneal astigmatism; CRC cis rs561341 1.000 rs542132 chr17:30307193 A/T cg12193833 chr17:30244370 NA -0.75 -8.79 -0.44 8.51e-17 Hip circumference adjusted for BMI; CRC cis rs10883723 0.810 rs11191304 chr10:104255284 C/T cg11453585 chr10:104263688 ACTR1A;SUFU 0.92 17.58 0.7 2.89e-49 Allergic disease (asthma, hay fever or eczema); CRC cis rs8072100 0.817 rs9912101 chr17:45547078 A/G cg25173405 chr17:45401733 C17orf57 -0.44 -6.94 -0.36 2.11e-11 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs11711311 1.000 rs12636577 chr3:113497507 A/G cg15478005 chr3:113465772 ATP6V1A;NAA50 0.43 5.94 0.31 7.06e-9 IgG glycosylation; CRC cis rs17270561 0.666 rs3923725 chr6:25734920 C/A cg16482183 chr6:26056742 HIST1H1C 0.85 10.66 0.51 5.33e-23 Iron status biomarkers; CRC cis rs11971779 0.680 rs6961812 chr7:139043808 A/C cg07862535 chr7:139043722 LUC7L2 0.57 7.35 0.38 1.61e-12 Diisocyanate-induced asthma; CRC cis rs9549367 0.577 rs3024711 chr13:113813268 A/G cg00898013 chr13:113819073 PROZ -0.47 -6.14 -0.32 2.36e-9 Platelet distribution width; CRC cis rs6500602 0.647 rs4785967 chr16:4523208 G/A cg08645402 chr16:4508243 NA 0.63 10.97 0.52 4.5e-24 Schizophrenia; CRC cis rs9488822 0.636 rs12524932 chr6:116330266 G/A cg05304507 chr6:116381966 FRK 0.3 8.24 0.41 4.03e-15 Cholesterol, total;LDL cholesterol; CRC cis rs7726839 0.540 rs55929359 chr5:595956 C/G cg17948913 chr5:572064 NA 0.51 5.85 0.31 1.16e-8 Obesity-related traits; CRC cis rs7584330 0.554 rs75559690 chr2:238428454 T/C cg08992911 chr2:238395768 MLPH 0.62 6.81 0.35 4.64e-11 Prostate cancer; CRC cis rs7412746 0.622 rs11552229 chr1:150783985 T/C cg15448220 chr1:150897856 SETDB1 0.55 7.9 0.4 4.33e-14 Melanoma; CRC cis rs909674 0.818 rs5757680 chr22:39844793 C/T cg24399712 chr22:39784796 NA 0.42 8.08 0.41 1.22e-14 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; CRC cis rs10463316 0.817 rs6879238 chr5:150820574 G/C cg03212797 chr5:150827313 SLC36A1 -0.46 -7.12 -0.37 6.67e-12 Metabolite levels (Pyroglutamine); CRC cis rs2952156 1.000 rs1810132 chr17:37866005 C/T cg20243544 chr17:37824526 PNMT 0.53 7.92 0.4 3.7e-14 Asthma; CRC trans rs7395662 1.000 rs4929903 chr11:48913332 T/G cg21153622 chr11:89784906 NA -0.48 -7.55 -0.38 4.34e-13 HDL cholesterol; CRC cis rs2878628 0.650 rs56098033 chr3:52758571 T/A cg05573699 chr3:52720067 GNL3;PBRM1 -0.48 -7.02 -0.36 1.27e-11 Intelligence (multi-trait analysis); CRC cis rs780096 0.546 rs12473776 chr2:27636474 A/G cg27432699 chr2:27873401 GPN1 -0.5 -7.6 -0.39 3.06e-13 Total body bone mineral density; CRC trans rs4130344 0.555 rs7664704 chr4:159866176 A/G cg10773016 chr4:6690812 NA 0.42 6.31 0.33 9.19e-10 Intelligence (multi-trait analysis); CRC cis rs6570726 0.935 rs400968 chr6:145819718 A/G cg13319975 chr6:146136371 FBXO30 -0.37 -5.63 -0.3 3.94e-8 Lobe attachment (rater-scored or self-reported); CRC cis rs6500395 0.928 rs2080509 chr16:48690915 T/C cg04672837 chr16:48644449 N4BP1 -0.44 -6.6 -0.34 1.65e-10 Response to tocilizumab in rheumatoid arthritis; CRC cis rs7412746 0.658 rs10305704 chr1:150804429 A/C cg17724175 chr1:150552817 MCL1 0.49 7.28 0.37 2.47e-12 Melanoma; CRC cis rs10256972 0.684 rs4724039 chr7:1111633 A/G cg22907277 chr7:1156413 C7orf50 0.5 7.5 0.38 6.12e-13 Longevity;Endometriosis; CRC cis rs11098499 0.731 rs10015579 chr4:120271802 T/C cg24375607 chr4:120327624 NA 0.45 7.28 0.37 2.53e-12 Corneal astigmatism; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg04132851 chr1:85155548 SSX2IP 0.46 6.07 0.32 3.5e-9 Thyroid stimulating hormone; CRC cis rs7580658 0.724 rs4662711 chr2:127990840 G/A cg09760422 chr2:128146352 NA -0.35 -6.83 -0.35 4.09e-11 Protein C levels; CRC cis rs12477438 0.501 rs12619780 chr2:99707307 C/T cg14399236 chr2:99771627 LIPT1;TSGA10 0.75 12.43 0.57 2.41e-29 Chronic sinus infection; CRC cis rs62064224 0.593 rs916663 chr17:30835833 A/C cg25809561 chr17:30822961 MYO1D -0.68 -11.72 -0.54 9.33e-27 Schizophrenia; CRC cis rs868943 0.714 rs1999930 chr6:116387134 C/T cg18764771 chr6:116381957 FRK 0.26 6.33 0.33 8.2e-10 Total cholesterol levels; CRC cis rs972578 0.765 rs713717 chr22:43396109 C/T cg01576275 chr22:43409880 NA -0.4 -6.23 -0.32 1.46e-9 Mean platelet volume; CRC cis rs2836974 0.965 rs9941894 chr21:40634058 C/T cg11890956 chr21:40555474 PSMG1 1.01 16.36 0.67 1.94e-44 Cognitive function; CRC cis rs10504229 1.000 rs55944282 chr8:58180821 A/G cg02725872 chr8:58115012 NA -0.38 -6.43 -0.33 4.44e-10 Developmental language disorder (linguistic errors); CRC cis rs9322193 0.926 rs952166 chr6:150119910 A/T cg00933542 chr6:150070202 PCMT1 0.28 5.63 0.3 3.86e-8 Lung cancer; CRC cis rs9660992 0.573 rs12125276 chr1:205199440 C/T cg00857998 chr1:205179979 DSTYK 0.43 5.69 0.3 2.83e-8 Mean corpuscular volume;Mean platelet volume; CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg19683962 chr4:108852534 CYP2U1 0.4 6.9 0.36 2.69e-11 Obesity-related traits; CRC cis rs6570726 0.935 rs386823 chr6:145841365 C/T cg23711669 chr6:146136114 FBXO30 0.68 12.16 0.56 2.33e-28 Lobe attachment (rater-scored or self-reported); CRC cis rs9479482 1.000 rs9479403 chr6:150337746 C/T cg25797454 chr6:150327115 RAET1K -0.37 -6.31 -0.33 8.83e-10 Alopecia areata; CRC cis rs870825 0.616 rs28649620 chr4:185648997 G/A cg04058563 chr4:185651563 MLF1IP 0.72 9.3 0.46 2.04e-18 Blood protein levels; CRC trans rs4942242 0.740 rs6561137 chr13:44231965 A/T cg19169023 chr15:41853346 TYRO3 -0.46 -6.78 -0.35 5.6e-11 Response to tocilizumab in rheumatoid arthritis; CRC cis rs2658782 1.000 rs2605582 chr11:93163799 C/T cg15737290 chr11:93063684 CCDC67 0.52 7.51 0.38 5.5e-13 Pulmonary function decline; CRC cis rs4629180 0.586 rs2048252 chr2:102138384 C/T cg04415270 chr2:102091202 RFX8 -0.37 -6.24 -0.33 1.32e-9 Chronic rhinosinusitis with nasal polyps; CRC cis rs9868809 0.772 rs9812200 chr3:48695667 A/G cg00383909 chr3:49044727 WDR6 -0.7 -7.5 -0.38 5.9e-13 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; CRC cis rs17711722 0.701 rs4467826 chr7:65368708 A/G cg11764359 chr7:65958608 NA 0.51 7.82 0.4 7.34e-14 Calcium levels; CRC cis rs8060686 0.920 rs16942887 chr16:67928042 G/A cg19582491 chr16:67682965 RLTPR -0.58 -6.91 -0.36 2.5e-11 HDL cholesterol;Metabolic syndrome; CRC cis rs35995292 0.500 rs8180877 chr7:38931258 G/A cg19327137 chr7:38886074 VPS41 0.62 10.18 0.49 2.48e-21 Subjective well-being (multi-trait analysis); CRC cis rs6973256 0.604 rs6975134 chr7:133531432 T/C cg03336402 chr7:133662267 EXOC4 -0.4 -5.65 -0.3 3.4e-8 Intelligence (multi-trait analysis); CRC cis rs7618915 0.547 rs34537256 chr3:52657472 A/G cg05573699 chr3:52720067 GNL3;PBRM1 -0.44 -6.22 -0.32 1.47e-9 Bipolar disorder; CRC cis rs10499694 0.933 rs998850 chr7:50607388 G/C cg18232548 chr7:50535776 DDC -0.41 -6.11 -0.32 2.88e-9 Body mass index; CRC cis rs854572 0.600 rs705382 chr7:94955221 C/G cg04155289 chr7:94953770 PON1 -0.73 -12.16 -0.56 2.48e-28 Paraoxonase activity; CRC cis rs704795 0.867 rs7566052 chr2:27628635 A/G cg12000995 chr2:27665139 KRTCAP3 -0.31 -6.43 -0.33 4.54e-10 Menopause (age at onset); CRC cis rs6952808 0.689 rs4719391 chr7:2048136 T/C cg00106254 chr7:1943704 MAD1L1 -0.48 -7.05 -0.36 1.03e-11 Bipolar disorder and schizophrenia; CRC cis rs6741819 0.826 rs12465410 chr2:7136373 G/A cg27144453 chr2:7172511 RNF144A -0.41 -5.97 -0.31 5.98e-9 Response to antipsychotic treatment; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg24672547 chr12:6977222 TPI1 0.43 6.17 0.32 1.97e-9 Anxiety disorder; CRC cis rs6951245 1.000 rs74347384 chr7:1072440 G/A cg18402987 chr7:1209562 NA 0.64 6.77 0.35 6.03e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs4481887 0.504 rs6587434 chr1:248355563 G/A cg00666640 chr1:248458726 OR2T12 0.43 7.05 0.36 1.05e-11 Common traits (Other); CRC cis rs977987 0.843 rs11149824 chr16:75431830 C/G cg03315344 chr16:75512273 CHST6 0.54 9.0 0.44 1.86e-17 Dupuytren's disease; CRC cis rs13108904 0.846 rs3775100 chr4:1225106 T/C cg23123621 chr4:1343375 KIAA1530 0.34 6.31 0.33 8.96e-10 Obesity-related traits; CRC cis rs11123170 0.543 rs2166421 chr2:113990242 T/C cg11763394 chr2:113992921 PAX8;LOC440839;LOC654433 0.5 5.61 0.3 4.21e-8 Renal function-related traits (BUN); CRC cis rs7107174 1.000 rs10899469 chr11:78018313 T/C cg02023728 chr11:77925099 USP35 0.54 7.6 0.39 3.18e-13 Testicular germ cell tumor; CRC cis rs4132509 1.000 rs10754807 chr1:243804158 G/A cg21452805 chr1:244014465 NA 0.44 6.03 0.32 4.37e-9 RR interval (heart rate); CRC cis rs9549328 0.643 rs4907567 chr13:113617533 C/T cg20742385 chr13:113633654 MCF2L 0.56 9.5 0.46 4.54e-19 Systolic blood pressure; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg03609636 chr11:102323712 TMEM123 0.45 6.55 0.34 2.23e-10 Intelligence (multi-trait analysis); CRC cis rs875971 1.000 rs6970030 chr7:65968679 T/C cg11764359 chr7:65958608 NA 0.63 10.25 0.49 1.39e-21 Aortic root size; CRC trans rs9914544 0.524 rs8071147 chr17:18790678 A/G cg21372672 chr17:16614065 CCDC144A -0.38 -6.1 -0.32 3e-9 Educational attainment (years of education); CRC cis rs2797160 0.967 rs2747718 chr6:126009109 C/A cg05901451 chr6:126070800 HEY2 0.4 6.17 0.32 1.99e-9 Endometrial cancer; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg00351210 chr15:91073794 CRTC3 0.45 6.37 0.33 6.47e-10 Anxiety disorder; CRC cis rs1707322 0.721 rs61784796 chr1:46163256 A/G cg03146154 chr1:46216737 IPP 0.67 9.82 0.48 3.95e-20 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs561341 1.000 rs55959993 chr17:30254771 C/G cg12193833 chr17:30244370 NA -0.73 -8.49 -0.42 7.41e-16 Hip circumference adjusted for BMI; CRC cis rs2067615 0.579 rs3910854 chr12:107165669 T/C cg13491945 chr12:107078410 RFX4 0.33 5.62 0.3 4.03e-8 Heart rate; CRC cis rs1218582 0.803 rs7531728 chr1:154840516 C/A cg24250549 chr1:154909240 PMVK 0.59 9.16 0.45 5.72e-18 Prostate cancer; CRC cis rs9814567 1.000 rs6806417 chr3:134211446 C/T cg06541857 chr3:134203789 ANAPC13;CEP63 0.4 6.12 0.32 2.69e-9 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC trans rs11098499 0.913 rs68128210 chr4:120137819 T/G cg25214090 chr10:38739885 LOC399744 0.5 7.55 0.38 4.29e-13 Corneal astigmatism; CRC trans rs9395066 0.545 rs12525009 chr6:44875843 C/T cg04786201 chr1:17185605 NA 0.29 6.09 0.32 3.17e-9 Height; CRC cis rs1129187 0.755 rs9471976 chr6:42920549 G/T cg27588902 chr6:42928151 GNMT -0.4 -7.24 -0.37 3.19e-12 Alzheimer's disease in APOE e4+ carriers; CRC cis rs208520 0.754 rs851592 chr6:66875175 G/T cg07460842 chr6:66804631 NA -1.03 -14.2 -0.62 4.96e-36 Exhaled nitric oxide output; CRC cis rs11249608 0.548 rs7704565 chr5:178473923 G/C cg01312482 chr5:178451176 ZNF879 -0.35 -5.74 -0.3 2.13e-8 Pubertal anthropometrics; CRC cis rs995000 0.931 rs10889331 chr1:62943007 G/T cg19896129 chr1:63156450 NA -0.39 -6.02 -0.31 4.78e-9 Triglyceride levels; CRC cis rs2576037 0.583 rs8096263 chr18:44515216 C/T cg23996704 chr18:44553084 KATNAL2 -0.38 -7.61 -0.39 2.93e-13 Personality dimensions; CRC cis rs9486719 1.000 rs34209750 chr6:96882215 G/T cg06623918 chr6:96969491 KIAA0776 -0.81 -9.51 -0.46 4.17e-19 Migraine;Coronary artery disease; CRC cis rs3768617 0.510 rs4652776 chr1:183091920 G/A ch.1.3577855R chr1:183094577 LAMC1 0.89 15.86 0.66 1.84e-42 Fuchs's corneal dystrophy; CRC cis rs9303542 0.559 rs12946931 chr17:46614080 T/C cg04904318 chr17:46607828 HOXB1 -0.53 -6.17 -0.32 2.02e-9 Ovarian cancer;Epithelial ovarian cancer; CRC cis rs6840360 0.615 rs2406973 chr4:152608339 G/T cg22705602 chr4:152727874 NA 0.34 5.63 0.3 3.88e-8 Intelligence (multi-trait analysis); CRC cis rs9902453 0.765 rs2264302 chr17:28057095 G/A cg26525008 chr17:28256777 EFCAB5;SSH2 -0.71 -11.98 -0.55 1.12e-27 Coffee consumption (cups per day); CRC cis rs6570726 1.000 rs450076 chr6:145847655 G/T cg13319975 chr6:146136371 FBXO30 -0.37 -5.61 -0.3 4.21e-8 Lobe attachment (rater-scored or self-reported); CRC cis rs1059312 0.808 rs12816551 chr12:129295616 T/C cg09035930 chr12:129282057 SLC15A4 0.53 8.87 0.44 4.85e-17 Systemic lupus erythematosus; CRC cis rs2832191 0.791 rs2832187 chr21:30485543 T/C cg24692254 chr21:30365293 RNF160 -0.71 -12.84 -0.58 7e-31 Dental caries; CRC cis rs2573652 0.755 rs1469830 chr15:100517403 G/T cg09918751 chr15:100517450 ADAMTS17 0.38 5.81 0.3 1.49e-8 Height; CRC cis rs7945705 0.747 rs1980428 chr11:9010497 A/G cg21881798 chr11:8931708 C11orf17;ST5 0.68 11.76 0.54 6.81e-27 Hemoglobin concentration; CRC cis rs7666738 0.830 rs13112037 chr4:98976986 A/T cg17366294 chr4:99064904 C4orf37 0.44 7.44 0.38 8.98e-13 Colonoscopy-negative controls vs population controls; CRC trans rs7580658 0.614 rs7585198 chr2:127962635 C/T cg19818293 chr12:96429861 LTA4H -0.44 -6.07 -0.32 3.58e-9 Protein C levels; CRC cis rs2019137 0.936 rs902696 chr2:113954879 G/T cg19083407 chr2:113993142 PAX8;LOC440839;LOC654433 0.45 6.33 0.33 7.89e-10 Lymphocyte counts; CRC cis rs7607369 0.719 rs12613545 chr2:219623504 C/T cg02176678 chr2:219576539 TTLL4 -0.39 -6.31 -0.33 8.79e-10 Red blood cell count;Amyotrophic lateral sclerosis; CRC cis rs644799 1.000 rs611020 chr11:95567905 C/T cg03916912 chr11:95522834 CEP57;FAM76B 0.96 18.09 0.71 2.94e-51 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs11148252 0.904 rs9526927 chr13:53051627 C/T cg12458913 chr13:53173898 NA 0.59 9.31 0.46 1.87e-18 Lewy body disease; CRC cis rs7666738 0.716 rs35195511 chr4:98859660 G/A cg05340658 chr4:99064831 C4orf37 0.56 8.27 0.41 3.38e-15 Colonoscopy-negative controls vs population controls; CRC trans rs853679 0.760 rs2299029 chr6:28198831 G/A cg06606381 chr12:133084897 FBRSL1 -0.6 -6.27 -0.33 1.13e-9 Depression; CRC cis rs911186 0.786 rs13211901 chr6:27187612 G/A cg12292205 chr6:26970375 C6orf41 -0.78 -8.68 -0.43 1.87e-16 Autism spectrum disorder or schizophrenia; CRC cis rs4713118 0.512 rs2622319 chr6:28120401 G/C cg10876282 chr6:28092338 ZSCAN16 0.5 6.71 0.35 8.65e-11 Parkinson's disease; CRC cis rs12286929 0.679 rs11601041 chr11:115083348 A/G cg04055981 chr11:115044050 NA 0.38 5.87 0.31 1.04e-8 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs9894429 1.000 rs9674872 chr17:79581931 T/A cg21028142 chr17:79581711 NPLOC4 0.39 8.62 0.43 2.89e-16 Eye color traits; CRC cis rs6952808 0.689 rs4719391 chr7:2048136 T/C cg19624444 chr7:2048497 MAD1L1 0.33 5.9 0.31 9.16e-9 Bipolar disorder and schizophrenia; CRC cis rs12044355 0.827 rs16854783 chr1:231827371 A/G cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.42 -5.97 -0.31 6.19e-9 Alzheimer's disease; CRC cis rs7481584 0.624 rs412842 chr11:3047448 A/G cg25174290 chr11:3078921 CARS -0.4 -5.65 -0.3 3.5e-8 Calcium levels; CRC cis rs9910055 0.529 rs228757 chr17:42164885 G/C cg09913183 chr17:42254507 C17orf65;ASB16 -0.46 -6.06 -0.32 3.68e-9 Total body bone mineral density; CRC trans rs3942852 0.688 rs10742834 chr11:48169717 G/A cg15704280 chr7:45808275 SEPT13 -0.75 -9.35 -0.46 1.43e-18 Acute lymphoblastic leukemia (childhood); CRC cis rs6426558 0.559 rs485234 chr1:227317747 A/G cg10327440 chr1:227177885 CDC42BPA 0.47 6.96 0.36 1.88e-11 Neutrophil percentage of white cells; CRC cis rs7927592 0.956 rs7113287 chr11:68372186 A/T cg16797656 chr11:68205561 LRP5 0.4 6.77 0.35 5.79e-11 Total body bone mineral density; CRC cis rs2645694 0.626 rs2703115 chr4:77824442 C/T cg10057126 chr4:77819792 ANKRD56 0.33 5.77 0.3 1.85e-8 Emphysema distribution in smoking; CRC cis rs17092148 0.887 rs4911431 chr20:33158318 G/A cg08999081 chr20:33150536 PIGU 0.51 6.26 0.33 1.19e-9 Neuroticism; CRC cis rs875971 0.522 rs4718286 chr7:65292764 A/G cg05627663 chr7:65219948 SNORA22;CCT6P1 0.48 7.27 0.37 2.6e-12 Aortic root size; CRC cis rs4862750 0.872 rs6811837 chr4:187898162 G/A cg22105103 chr4:187893119 NA 0.64 11.59 0.54 2.84e-26 Lobe attachment (rater-scored or self-reported); CRC cis rs10504229 0.683 rs7827881 chr8:58132137 C/T cg21724239 chr8:58056113 NA 0.48 6.72 0.35 8.1e-11 Developmental language disorder (linguistic errors); CRC cis rs478304 0.654 rs10896032 chr11:65459419 C/A cg05805236 chr11:65401703 PCNXL3 -0.41 -6.61 -0.34 1.59e-10 Acne (severe); CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg02998992 chr17:19265610 B9D1 0.38 6.1 0.32 2.95e-9 Obesity-related traits; CRC cis rs7814319 0.870 rs2292836 chr8:97239613 A/C cg20787634 chr8:97240163 UQCRB -0.53 -9.25 -0.45 2.86e-18 Lung function (FVC); CRC cis rs62229266 0.659 rs62230814 chr21:37403546 G/A cg12218747 chr21:37451666 NA -0.36 -6.16 -0.32 2.16e-9 Mitral valve prolapse; CRC cis rs2000999 0.778 rs12445401 chr16:72148419 A/G cg23815491 chr16:72088622 HP 0.56 6.76 0.35 6.48e-11 Total cholesterol levels;Cholesterol, total;Blood protein levels;LDL cholesterol levels;Haptoglobin levels;LDL cholesterol; CRC cis rs7584330 0.666 rs1574530 chr2:238395708 A/T cg14458575 chr2:238380390 NA 0.68 9.17 0.45 5.27e-18 Prostate cancer; CRC trans rs2243480 1.000 rs419603 chr7:65597341 C/T cg10756647 chr7:56101905 PSPH 0.74 7.74 0.39 1.23e-13 Diabetic kidney disease; CRC cis rs10744422 1.000 rs3817094 chr12:123332032 T/C cg25930673 chr12:123319894 HIP1R -0.59 -6.24 -0.33 1.33e-9 Schizophrenia; CRC cis rs1862618 0.671 rs2591970 chr5:56232595 T/C cg24531977 chr5:56204891 C5orf35 0.68 10.4 0.5 4.24e-22 Initial pursuit acceleration; CRC cis rs9911578 0.839 rs7208505 chr17:57187729 C/T cg05425664 chr17:57184151 TRIM37 -0.49 -7.85 -0.4 6.11e-14 Intelligence (multi-trait analysis); CRC cis rs1997103 1.000 rs9649851 chr7:55398692 C/A cg17469321 chr7:55412551 NA 0.74 11.4 0.53 1.38e-25 QRS interval (sulfonylurea treatment interaction); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg07919955 chr2:233415416 EIF4E2;TIGD1 0.44 6.26 0.33 1.17e-9 Intelligence (multi-trait analysis); CRC cis rs501120 1.000 rs1746048 chr10:44775824 A/G cg09554077 chr10:44749378 NA -0.73 -10.85 -0.51 1.23e-23 Coronary artery disease;Coronary heart disease; CRC trans rs7615952 0.546 rs2922194 chr3:125332263 G/A cg21747405 chr11:67723411 NA -0.49 -6.2 -0.32 1.74e-9 Blood pressure (smoking interaction); CRC trans rs12478296 0.901 rs7423119 chr2:243005488 T/A cg06834434 chr14:75079333 LTBP2 0.55 6.91 0.36 2.51e-11 Obesity-related traits; CRC cis rs3008870 0.959 rs4655658 chr1:67389608 C/T cg08660285 chr1:67390436 MIER1;WDR78 1.03 15.71 0.65 6.8e-42 Lymphocyte percentage of white cells; CRC cis rs79976124 0.879 rs12214239 chr6:66636059 A/G cg07460842 chr6:66804631 NA 0.77 9.45 0.46 6.33e-19 Type 2 diabetes; CRC trans rs66573146 0.901 rs55659111 chr4:7012338 G/T cg07817883 chr1:32538562 TMEM39B 1.69 12.41 0.56 2.99e-29 Granulocyte percentage of myeloid white cells; CRC cis rs4664293 0.967 rs1006192 chr2:160567589 G/T cg08347373 chr2:160653686 CD302 -0.44 -7.16 -0.37 5.3e-12 Monocyte percentage of white cells; CRC cis rs6938 0.534 rs11072512 chr15:75204026 C/T cg17294928 chr15:75287854 SCAMP5 0.57 8.72 0.43 1.42e-16 Breast cancer; CRC cis rs921968 0.541 rs733925 chr2:219302466 G/A cg02176678 chr2:219576539 TTLL4 -0.55 -8.73 -0.43 1.27e-16 Mean corpuscular hemoglobin concentration; CRC cis rs1862618 0.525 rs832403 chr5:56265992 G/T cg22800045 chr5:56110881 MAP3K1 -0.54 -5.78 -0.3 1.73e-8 Initial pursuit acceleration; CRC cis rs7552404 1.000 rs7516226 chr1:76234257 G/A cg10523679 chr1:76189770 ACADM 0.85 11.55 0.54 3.84e-26 Blood metabolite levels;Acylcarnitine levels; CRC cis rs10274279 0.660 rs10278007 chr7:157372906 C/G cg26886268 chr7:157387156 PTPRN2 -0.43 -5.77 -0.3 1.83e-8 Myopia (pathological); CRC cis rs7692995 1.000 rs6841793 chr4:17933810 C/G cg08925142 chr4:18023851 LCORL -0.52 -5.82 -0.31 1.41e-8 Height; CRC cis rs2153535 0.601 rs718504 chr6:8527512 A/G cg21535247 chr6:8435926 SLC35B3 0.49 7.47 0.38 7.44e-13 Motion sickness; CRC cis rs4474465 0.790 rs10793331 chr11:78270000 C/T cg27205649 chr11:78285834 NARS2 0.47 6.01 0.31 4.93e-9 Alzheimer's disease (survival time); CRC cis rs4975616 0.869 rs452932 chr5:1330253 T/C cg06550200 chr5:1325588 CLPTM1L -0.74 -12.24 -0.56 1.22e-28 Lung cancer; CRC cis rs8180040 0.701 rs1079276 chr3:47045739 C/G cg02527881 chr3:46936655 PTH1R -0.38 -7.01 -0.36 1.35e-11 Colorectal cancer; CRC cis rs9517313 0.770 rs9517301 chr13:99095088 A/G cg07423050 chr13:99094983 FARP1 -0.59 -9.71 -0.47 9.05e-20 Neuroticism; CRC trans rs7618501 1.000 rs7374277 chr3:49784777 T/C cg21659725 chr3:3221576 CRBN -0.9 -17.21 -0.69 8.44e-48 Intelligence (multi-trait analysis); CRC cis rs11122272 0.735 rs2024878 chr1:231528415 A/C cg06096015 chr1:231504339 EGLN1 -0.4 -6.01 -0.31 4.99e-9 Hemoglobin concentration; CRC cis rs898097 0.841 rs11656358 chr17:80853956 G/A cg19046167 chr17:80928561 B3GNTL1 -0.42 -6.54 -0.34 2.29e-10 Breast cancer; CRC cis rs1448094 0.512 rs7957170 chr12:86243282 A/G cg19622623 chr12:86230825 RASSF9 -0.41 -6.7 -0.35 9.04e-11 Major depressive disorder; CRC trans rs12438356 0.686 rs8043162 chr15:69487209 G/A cg26416341 chr12:54718712 COPZ1 0.65 6.0 0.31 5.07e-9 CTACK levels; CRC cis rs798554 0.610 rs2644297 chr7:2858906 A/C cg17321639 chr7:2759063 NA -0.38 -5.8 -0.3 1.57e-8 Height; CRC cis rs2832191 0.703 rs2853827 chr21:30443596 T/C cg24692254 chr21:30365293 RNF160 0.86 16.42 0.67 1.1e-44 Dental caries; CRC cis rs79976124 0.800 rs6918860 chr6:66637741 G/C cg07460842 chr6:66804631 NA 0.7 8.78 0.44 9.05e-17 Type 2 diabetes; CRC cis rs2288073 0.930 rs7604097 chr2:24401805 G/C cg06627628 chr2:24431161 ITSN2 -0.72 -9.87 -0.48 2.67e-20 Venous thromboembolism (SNP x SNP interaction); CRC cis rs7666738 0.618 rs10856932 chr4:98819992 C/T cg05340658 chr4:99064831 C4orf37 0.54 7.74 0.39 1.19e-13 Colonoscopy-negative controls vs population controls; CRC cis rs10504229 0.517 rs75486476 chr8:58056079 G/T cg02725872 chr8:58115012 NA -0.32 -5.79 -0.3 1.61e-8 Developmental language disorder (linguistic errors); CRC cis rs6089584 0.586 rs4925216 chr20:60599923 G/A cg06108461 chr20:60628389 TAF4 -0.64 -10.37 -0.5 5.31e-22 Body mass index; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg20921688 chr2:71357800 MCEE;MPHOSPH10 0.45 6.32 0.33 8.66e-10 Response to antipsychotic treatment; CRC cis rs6840360 0.642 rs2709818 chr4:152382634 A/G cg09659197 chr4:152720779 NA 0.33 6.57 0.34 1.94e-10 Intelligence (multi-trait analysis); CRC cis rs501916 0.833 rs11855134 chr15:48047676 A/G cg16110827 chr15:48056943 SEMA6D -0.54 -8.29 -0.42 2.93e-15 Inflammatory bowel disease;Ulcerative colitis; CRC cis rs6503525 0.628 rs62068171 chr17:38103242 G/A cg17344932 chr17:38183730 MED24;SNORD124 -0.43 -6.83 -0.35 4.24e-11 Asthma; CRC cis rs6545883 0.929 rs2593635 chr2:61634706 A/C cg15711740 chr2:61764176 XPO1 0.48 6.18 0.32 1.91e-9 Tuberculosis; CRC cis rs7208859 0.623 rs7223404 chr17:29107363 C/T cg01831904 chr17:28903510 LRRC37B2 -0.63 -6.45 -0.33 4.07e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs12291225 0.546 rs12795545 chr11:14355564 G/A cg19336497 chr11:14380999 RRAS2 -0.53 -9.3 -0.46 2.09e-18 Sense of smell; CRC cis rs9311474 1.000 rs9311474 chr3:52338852 T/C cg18099408 chr3:52552593 STAB1 -0.49 -8.38 -0.42 1.51e-15 Electroencephalogram traits; CRC trans rs9858542 0.953 rs9827021 chr3:49514764 C/A cg21582582 chr3:182698605 DCUN1D1 -0.51 -6.43 -0.33 4.42e-10 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs35264875 0.898 rs56140802 chr11:68861631 G/A cg03469862 chr11:68924853 NA 0.47 6.03 0.32 4.33e-9 Blond vs. brown hair color; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg15538837 chr1:226250361 H3F3A;LOC440926 0.48 6.18 0.32 1.85e-9 Thyroid stimulating hormone; CRC cis rs79387448 0.638 rs11465670 chr2:103034440 A/G cg09003973 chr2:102972529 NA 0.77 8.79 0.44 8.57e-17 Gut microbiota (bacterial taxa); CRC cis rs1348850 0.626 rs1901825 chr2:178225331 A/T cg22681709 chr2:178499509 PDE11A -0.33 -6.08 -0.32 3.4e-9 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs9910055 0.529 rs850851 chr17:42177674 C/T cg10896456 chr17:42255109 ASB16;C17orf65 -0.39 -5.94 -0.31 7.35e-9 Total body bone mineral density; CRC cis rs1030268 0.607 rs34218501 chr7:133210375 G/A cg10665199 chr7:133106180 EXOC4 0.63 7.63 0.39 2.56e-13 Intelligence (multi-trait analysis); CRC cis rs1997103 1.000 rs9649781 chr7:55411809 A/G cg17469321 chr7:55412551 NA 0.72 11.02 0.52 2.98e-24 QRS interval (sulfonylurea treatment interaction); CRC cis rs2559856 1.000 rs2695286 chr12:102088507 T/C cg12924262 chr12:102091054 CHPT1 0.55 8.26 0.41 3.59e-15 Blood protein levels; CRC cis rs11608355 1.000 rs7958625 chr12:109869218 A/T cg19025524 chr12:109796872 NA -0.47 -6.77 -0.35 5.8e-11 Neuroticism; CRC cis rs6674176 0.628 rs4660759 chr1:44432500 C/G cg12908607 chr1:44402522 ARTN -0.54 -9.67 -0.47 1.21e-19 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Cognitive ability; CRC cis rs1552244 1.000 rs33917318 chr3:10067797 T/C cg18598329 chr3:10140678 FANCD2;C3orf24 -0.89 -12.28 -0.56 8.67e-29 Alzheimer's disease; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg16293249 chr2:112812957 TMEM87B 0.4 6.17 0.32 2.05e-9 Liver disease severity in Alagille syndrome; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg22834172 chr17:37774349 NA 0.42 6.12 0.32 2.73e-9 Intelligence (multi-trait analysis); CRC cis rs8177253 0.761 rs1830083 chr3:133508551 G/A cg11941060 chr3:133502564 NA -0.69 -12.33 -0.56 5.45e-29 Iron status biomarkers; CRC cis rs6951245 0.554 rs79367977 chr7:1152657 G/A cg20603222 chr7:1096387 C7orf50;GPR146 -0.44 -5.67 -0.3 3.08e-8 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC trans rs12639288 0.962 rs12638639 chr3:167660757 C/T cg21037378 chr4:142142045 ZNF330 -0.5 -6.08 -0.32 3.29e-9 Hirschsprung disease; CRC cis rs7618915 0.547 rs11130323 chr3:52770277 T/C cg15147215 chr3:52552868 STAB1 -0.61 -10.01 -0.48 9.16e-21 Bipolar disorder; CRC cis rs1215050 0.791 rs260899 chr4:98707046 G/A cg05340658 chr4:99064831 C4orf37 0.48 7.09 0.36 8.48e-12 Waist-to-hip ratio adjusted for body mass index; CRC cis rs6540559 0.673 rs17015218 chr1:209967915 A/G cg23283495 chr1:209979779 IRF6 0.48 6.83 0.35 4.21e-11 Cleft lip with or without cleft palate; CRC trans rs10506458 0.915 rs17687426 chr12:63397900 G/C cg03429785 chr15:59498649 MYO1E;LDHAL6B -1.4 -20.6 -0.75 3.83e-61 Hemostatic factors and hematological phenotypes; CRC cis rs9311474 0.632 rs6445528 chr3:52572447 C/T cg07507251 chr3:52567010 NT5DC2 -0.39 -5.75 -0.3 2.09e-8 Electroencephalogram traits; CRC cis rs9372498 0.536 rs62424199 chr6:118827252 G/A cg01339444 chr6:118972232 C6orf204 0.53 6.06 0.32 3.76e-9 Diastolic blood pressure; CRC cis rs6723226 0.803 rs387780 chr2:32502495 T/C cg02381751 chr2:32503542 YIPF4 0.58 8.15 0.41 7.89e-15 Intelligence (multi-trait analysis); CRC cis rs1552244 0.572 rs59074548 chr3:10164347 G/C cg16606324 chr3:10149918 C3orf24 0.66 7.74 0.39 1.19e-13 Alzheimer's disease; CRC cis rs1448094 0.791 rs61929395 chr12:86331584 A/T cg02569458 chr12:86230093 RASSF9 0.45 7.66 0.39 2.16e-13 Major depressive disorder; CRC cis rs4481887 1.000 rs10888362 chr1:248483975 A/G cg13385794 chr1:248469461 NA -0.39 -6.87 -0.35 3.28e-11 Common traits (Other); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg17998333 chr10:121356721 TIAL1 0.44 6.11 0.32 2.79e-9 Response to antipsychotic treatment; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg00727112 chr4:159690372 FNIP2 0.47 6.45 0.34 4.02e-10 Response to antipsychotic treatment; CRC cis rs11608355 0.545 rs55902232 chr12:109902305 G/A cg05360138 chr12:110035743 NA 0.77 8.7 0.43 1.65e-16 Neuroticism; CRC cis rs60843830 1.000 rs60149603 chr2:285421 A/G cg00108164 chr2:264199 ACP1;SH3YL1 0.62 9.66 0.47 1.3e-19 Spherical equivalent (joint analysis main effects and education interaction); CRC cis rs853679 1.000 rs6901575 chr6:28250984 G/A cg15786705 chr6:28176104 NA 0.6 6.19 0.32 1.78e-9 Depression; CRC cis rs909002 0.800 rs968335 chr1:32085776 G/A cg13919466 chr1:32135498 COL16A1 -0.31 -5.81 -0.31 1.44e-8 Intelligence (multi-trait analysis); CRC cis rs11105298 0.891 rs4842653 chr12:89834113 C/T cg08166232 chr12:89918718 WDR51B;GALNT4 -0.61 -7.74 -0.39 1.27e-13 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; CRC cis rs9549367 0.756 rs2316463 chr13:113901406 C/T cg00898013 chr13:113819073 PROZ -0.47 -6.54 -0.34 2.3e-10 Platelet distribution width; CRC cis rs28386778 0.897 rs2727287 chr17:61904728 G/A cg06601766 chr17:61851465 DDX42;CCDC47 0.43 5.91 0.31 8.43e-9 Prudent dietary pattern; CRC cis rs28386778 0.897 rs11079510 chr17:61820902 T/C cg25654072 chr17:61904446 PSMC5;FTSJ3 0.71 11.06 0.52 2.24e-24 Prudent dietary pattern; CRC cis rs317865 0.867 rs7668729 chr4:16180391 A/C cg04764131 chr4:16228633 TAPT1;FLJ39653 -0.55 -5.81 -0.31 1.46e-8 Kidney disease (early stage) in type 1 diabetes; CRC cis rs12477438 0.520 rs11695379 chr2:99742161 A/G cg14399236 chr2:99771627 LIPT1;TSGA10 0.82 14.41 0.62 7.61e-37 Chronic sinus infection; CRC cis rs11229555 0.874 rs11229512 chr11:58286105 T/C cg15696309 chr11:58395628 NA -0.95 -12.53 -0.57 1.06e-29 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; CRC cis rs6500602 0.702 rs2304634 chr16:4500544 C/T cg08645402 chr16:4508243 NA 0.6 10.52 0.5 1.71e-22 Schizophrenia; CRC cis rs6952808 0.729 rs35797753 chr7:1954914 G/A cg20295408 chr7:1910781 MAD1L1 -0.41 -5.7 -0.3 2.66e-8 Bipolar disorder and schizophrenia; CRC cis rs7927771 0.864 rs7937331 chr11:47430458 T/C cg20135002 chr11:47629003 NA 0.35 5.73 0.3 2.29e-8 Subjective well-being; CRC cis rs1552244 0.572 rs3843008 chr3:10173742 C/T cg02579736 chr3:10068473 FANCD2;CIDECP 1.05 10.6 0.5 8.86e-23 Alzheimer's disease; CRC trans rs9858542 1.000 rs9812791 chr3:49682311 G/A cg21665057 chr3:196295764 WDR53;FBXO45 -0.68 -8.9 -0.44 3.71e-17 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs9916302 0.555 rs12940193 chr17:37652178 T/G cg15445000 chr17:37608096 MED1 0.42 9.26 0.45 2.8e-18 Glomerular filtration rate (creatinine); CRC cis rs66573146 0.572 rs73199995 chr4:6955801 G/C cg26116260 chr4:7069785 GRPEL1 -0.6 -5.77 -0.3 1.79e-8 Granulocyte percentage of myeloid white cells; CRC cis rs4964805 0.657 rs11111781 chr12:104187440 C/T cg02344784 chr12:104178138 NT5DC3 0.78 15.04 0.64 2.92e-39 Attention deficit hyperactivity disorder; CRC trans rs11671005 0.610 rs2305122 chr19:59056752 G/C cg22037779 chr5:139682734 PFDN1 -0.53 -6.18 -0.32 1.9e-9 Mean platelet volume; CRC cis rs11098699 0.821 rs11735364 chr4:124185679 T/C cg09941581 chr4:124220074 SPATA5 0.4 5.74 0.3 2.12e-8 Mosquito bite size; CRC cis rs4555082 0.874 rs2816620 chr14:105732704 G/T cg06808227 chr14:105710500 BRF1 -0.61 -8.58 -0.43 3.85e-16 Mean platelet volume;Platelet distribution width; CRC cis rs972578 1.000 rs3819677 chr22:43386691 C/G cg01576275 chr22:43409880 NA -0.48 -7.69 -0.39 1.68e-13 Mean platelet volume; CRC cis rs2239547 0.657 rs3755803 chr3:52866157 C/G cg18404041 chr3:52824283 ITIH1 -0.41 -7.6 -0.39 3.03e-13 Schizophrenia; CRC cis rs7998202 0.614 rs420431 chr13:113346317 C/G cg02820901 chr13:113351484 ATP11A -0.64 -6.85 -0.35 3.65e-11 Glycated hemoglobin levels; CRC cis rs911119 0.913 rs13043266 chr20:23588127 C/T cg16589663 chr20:23618590 CST3 0.57 7.36 0.38 1.51e-12 Chronic kidney disease; CRC cis rs56235845 0.964 rs11746443 chr5:176798306 G/A cg22155724 chr5:176794405 RGS14 0.41 5.78 0.3 1.7e-8 Hemoglobin concentration;Hematocrit; CRC cis rs6499255 1.000 rs4464069 chr16:69816284 C/T cg00738113 chr16:70207722 CLEC18C -0.43 -6.51 -0.34 2.73e-10 IgE levels; CRC cis rs514406 0.825 rs6695819 chr1:53223366 T/C cg08859206 chr1:53392774 SCP2 0.42 6.56 0.34 2.14e-10 Monocyte count; CRC cis rs13064411 0.696 rs2399479 chr3:113227050 G/A cg18753928 chr3:113234510 CCDC52 -0.69 -10.47 -0.5 2.42e-22 Response to simvastatin treatment (PCSK9 protein level change); CRC cis rs17125944 0.505 rs10483617 chr14:53202605 A/G cg00686598 chr14:53173677 PSMC6 -1.16 -10.54 -0.5 1.45e-22 Alzheimer's disease (late onset); CRC cis rs13064411 0.735 rs10511326 chr3:113216325 T/C cg10517650 chr3:113235015 CCDC52 -0.41 -7.18 -0.37 4.55e-12 Response to simvastatin treatment (PCSK9 protein level change); CRC cis rs748404 0.604 rs2278857 chr15:43632549 T/C cg02155558 chr15:43621948 ADAL;LCMT2 0.52 7.76 0.39 1.08e-13 Lung cancer; CRC cis rs798554 0.757 rs1182179 chr7:2873648 A/G cg19346786 chr7:2764209 NA -0.41 -7.04 -0.36 1.11e-11 Height; CRC trans rs1455244 0.700 rs7229302 chr18:11508904 G/T cg18022193 chr19:913536 C19orf22 0.42 6.32 0.33 8.53e-10 Schizophrenia; CRC cis rs10911251 0.546 rs1547714 chr1:183114119 C/T ch.1.3577855R chr1:183094577 LAMC1 0.83 14.65 0.63 9.3e-38 Colorectal cancer; CRC cis rs6952808 0.929 rs11761270 chr7:1923695 C/T cg00106254 chr7:1943704 MAD1L1 -0.53 -7.92 -0.4 3.69e-14 Bipolar disorder and schizophrenia; CRC cis rs1801251 0.929 rs10933409 chr2:233629386 A/G cg25237894 chr2:233734115 C2orf82 0.54 8.8 0.44 7.77e-17 Coronary artery disease; CRC cis rs4713118 0.513 rs149975 chr6:27986340 G/A cg02683197 chr6:28174875 NA 0.63 8.57 0.43 4.06e-16 Parkinson's disease; CRC cis rs62244186 0.632 rs1402751 chr3:44594030 C/A cg10263370 chr3:44754102 ZNF502 -0.36 -6.1 -0.32 2.98e-9 Depressive symptoms; CRC cis rs1681630 0.848 rs1631174 chr11:47974373 A/C cg05585544 chr11:47624801 NA -0.42 -7.02 -0.36 1.25e-11 Height; CRC cis rs9322193 0.923 rs9688938 chr6:150110077 G/A cg07701084 chr6:150067640 NUP43 0.47 6.61 0.34 1.51e-10 Lung cancer; CRC cis rs9902453 0.845 rs7221516 chr17:28232506 G/A cg26525008 chr17:28256777 EFCAB5;SSH2 0.66 10.57 0.5 1.1e-22 Coffee consumption (cups per day); CRC cis rs892085 0.681 rs10417071 chr19:10872431 G/T cg17710535 chr19:10819994 QTRT1 0.38 5.8 0.3 1.59e-8 Psoriasis vulgaris;Psoriasis; CRC cis rs853679 0.517 rs56310871 chr6:28044482 A/G cg21251018 chr6:28226885 NKAPL 0.47 6.16 0.32 2.07e-9 Depression; CRC cis rs910316 0.789 rs175444 chr14:75601782 G/C cg11812906 chr14:75593930 NEK9 -0.54 -8.24 -0.41 4.05e-15 Height; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg09430391 chr4:46392972 GABRA2 0.41 6.3 0.33 9.67e-10 Liver disease severity in Alagille syndrome; CRC cis rs9547692 0.877 rs9652258 chr13:37476123 G/C cg01493522 chr13:37497338 NA -0.56 -7.65 -0.39 2.21e-13 Coronary artery disease; CRC cis rs1799949 1.000 rs11654452 chr17:41189383 G/T cg05368731 chr17:41323189 NBR1 0.69 10.07 0.49 5.76e-21 Menopause (age at onset); CRC cis rs10876993 0.928 rs1678532 chr12:58055197 T/G cg18357645 chr12:58087776 OS9 0.56 7.61 0.39 3e-13 Celiac disease or Rheumatoid arthritis; CRC cis rs6460942 0.591 rs62448726 chr7:12330881 A/G cg20607287 chr7:12443886 VWDE -0.56 -6.15 -0.32 2.21e-9 Coronary artery disease; CRC cis rs801193 0.935 rs3800820 chr7:66147178 C/T cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.43 -6.3 -0.33 9.32e-10 Aortic root size; CRC cis rs34375054 0.525 rs7133614 chr12:125605957 C/T cg06987292 chr12:125626746 AACS -0.35 -6.02 -0.32 4.54e-9 Post bronchodilator FEV1/FVC ratio; CRC cis rs3008870 1.000 rs2815361 chr1:67494591 G/T cg08660285 chr1:67390436 MIER1;WDR78 1.01 14.69 0.63 6.23e-38 Lymphocyte percentage of white cells; CRC cis rs2832191 0.791 rs8134407 chr21:30476586 G/A cg24692254 chr21:30365293 RNF160 0.71 12.56 0.57 7.87e-30 Dental caries; CRC cis rs9611519 1.000 rs9611505 chr22:41540279 T/C cg03806693 chr22:41940476 POLR3H -0.58 -7.21 -0.37 3.83e-12 Neuroticism; CRC cis rs6435862 0.636 rs717548 chr2:215676905 G/A cg04004882 chr2:215674386 BARD1 -0.66 -10.83 -0.51 1.36e-23 Neuroblastoma (high-risk); CRC cis rs7811142 0.830 rs73401451 chr7:99981895 T/C cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.11 16.03 0.66 3.87e-43 Platelet count; CRC cis rs1129187 0.755 rs3293 chr6:42938377 G/T cg02359409 chr6:42947317 PEX6 -0.7 -11.85 -0.55 3.11e-27 Alzheimer's disease in APOE e4+ carriers; CRC cis rs7264396 0.563 rs78084033 chr20:34219990 A/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.46 -5.8 -0.3 1.58e-8 Total cholesterol levels; CRC cis rs6545883 0.929 rs7563678 chr2:61741811 C/T cg15711740 chr2:61764176 XPO1 0.49 6.91 0.36 2.51e-11 Tuberculosis; CRC cis rs17345786 0.817 rs11720560 chr3:101328484 C/T cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.57 6.65 0.34 1.26e-10 Colonoscopy-negative controls vs population controls; CRC cis rs67478160 0.643 rs2024667 chr14:104211529 T/G cg01849466 chr14:104193079 ZFYVE21 -0.49 -8.7 -0.43 1.67e-16 Schizophrenia; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg02081364 chr1:247267551 ZNF669 0.44 6.09 0.32 3.09e-9 Response to antipsychotic treatment; CRC cis rs9914988 0.943 rs9907178 chr17:27124307 G/C cg20469991 chr17:27169893 C17orf63 -0.6 -7.27 -0.37 2.59e-12 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs6684514 1.000 rs2270291 chr1:156244992 G/C cg16558208 chr1:156270281 VHLL 0.58 9.08 0.45 1.03e-17 Mean corpuscular hemoglobin concentration;Glycated hemoglobin levels; CRC cis rs9467160 0.817 rs12194966 chr6:24437611 G/A cg20631270 chr6:24437470 GPLD1 0.52 5.88 0.31 9.88e-9 Liver enzyme levels; CRC cis rs1405069 0.809 rs1046279 chr6:36932571 C/T cg26433444 chr6:36932349 PI16 -0.37 -6.68 -0.35 1.03e-10 Chemerin levels; CRC cis rs2303759 1.000 rs2303759 chr19:49869051 T/G cg22590775 chr19:49891494 CCDC155 0.64 9.16 0.45 5.63e-18 Multiple sclerosis; CRC cis rs2032447 0.714 rs199739 chr6:25960509 A/C cg15691649 chr6:25882328 NA -0.43 -5.83 -0.31 1.35e-8 Intelligence (multi-trait analysis); CRC cis rs13108904 0.901 rs1316393 chr4:1315619 A/G cg02018176 chr4:1364513 KIAA1530 -0.46 -7.6 -0.39 3.18e-13 Obesity-related traits; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg12502759 chr12:99039019 APAF1;IKBIP 0.48 7.18 0.37 4.79e-12 Response to antipsychotic treatment; CRC trans rs79976124 0.837 rs75346757 chr6:66648386 A/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.76 9.59 0.47 2.26e-19 Type 2 diabetes; CRC cis rs4664293 0.667 rs3815876 chr2:160640151 A/G cg08347373 chr2:160653686 CD302 -0.5 -8.61 -0.43 3.16e-16 Monocyte percentage of white cells; CRC cis rs2019137 0.539 rs11123170 chr2:113978940 C/G cg25243455 chr2:114033360 PAX8;LOC440839 -0.31 -7.28 -0.37 2.45e-12 Lymphocyte counts; CRC cis rs4713118 0.586 rs6905522 chr6:28086479 A/C cg12172441 chr6:28176163 NA 0.62 7.27 0.37 2.56e-12 Parkinson's disease; CRC cis rs4819052 1.000 rs9984901 chr21:46663952 C/T cg19498844 chr21:46707878 POFUT2;LOC642852 0.84 11.18 0.52 8.06e-25 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs2072510 0.569 rs7134975 chr12:96390420 C/A cg22491680 chr12:96389547 HAL -0.5 -6.16 -0.32 2.16e-9 Metabolite levels (small molecules and protein measures); CRC cis rs1348850 0.914 rs10170667 chr2:178336878 A/G cg22681709 chr2:178499509 PDE11A -0.4 -7.31 -0.37 2.07e-12 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs4332037 0.851 rs10268609 chr7:1962163 A/C cg24505167 chr7:1915268 MAD1L1 -0.4 -5.87 -0.31 1.06e-8 Bipolar disorder; CRC cis rs7584330 0.657 rs10202292 chr2:238352185 A/T cg16989719 chr2:238392110 NA -0.44 -8.0 -0.4 2.11e-14 Prostate cancer; CRC cis rs6500602 0.964 rs2896893 chr16:4478559 T/A cg14951292 chr16:4525986 HMOX2;NMRAL1 0.51 7.54 0.38 4.7e-13 Schizophrenia; CRC cis rs904251 0.965 rs1317563 chr6:37451854 G/T cg01843034 chr6:37503916 NA -0.33 -5.86 -0.31 1.14e-8 Cognitive performance; CRC cis rs1401999 1.000 rs6800217 chr3:183685893 T/C cg20387954 chr3:183756860 HTR3D 0.44 7.55 0.38 4.43e-13 Anterior chamber depth; CRC cis rs2836950 0.545 rs1888489 chr21:40533164 T/C cg17971929 chr21:40555470 PSMG1 -0.53 -7.7 -0.39 1.61e-13 Menarche (age at onset); CRC cis rs2882667 0.690 rs7446631 chr5:138227065 A/G cg09476006 chr5:138032270 NA 0.56 10.02 0.48 8.34e-21 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs72945132 0.678 rs35733235 chr11:70235595 C/T cg14191688 chr11:70257035 CTTN 0.57 7.86 0.4 5.55e-14 Coronary artery disease; CRC cis rs11098499 0.580 rs12509234 chr4:120319434 T/C cg24375607 chr4:120327624 NA 0.51 7.79 0.39 8.79e-14 Corneal astigmatism; CRC cis rs9399135 0.933 rs7755680 chr6:135294259 A/G cg24558204 chr6:135376177 HBS1L 0.5 7.85 0.4 5.94e-14 Red blood cell count; CRC cis rs9435341 0.762 rs72697623 chr1:107554269 G/A cg14671364 chr1:107599128 PRMT6 0.49 6.56 0.34 2.11e-10 Facial morphology (factor 21, depth of nasal alae); CRC cis rs6570726 0.935 rs391820 chr6:145821284 C/T cg05347473 chr6:146136440 FBXO30 0.39 6.06 0.32 3.69e-9 Lobe attachment (rater-scored or self-reported); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg10352719 chr14:24769404 DHRS1;C14orf21 0.45 6.41 0.33 5.01e-10 Response to antipsychotic treatment; CRC cis rs9291683 0.527 rs3822241 chr4:10094931 G/A cg00071950 chr4:10020882 SLC2A9 -0.54 -9.09 -0.45 9.54e-18 Bone mineral density; CRC cis rs7909074 1.000 rs4948926 chr10:45392604 G/C cg05187965 chr10:45406764 TMEM72 -0.38 -8.86 -0.44 5.01e-17 Mean corpuscular volume; CRC cis rs875971 1.000 rs6958277 chr7:65979349 A/G cg18912574 chr7:65842487 NCRNA00174 0.36 6.16 0.32 2.15e-9 Aortic root size; CRC cis rs9388451 0.903 rs9388446 chr6:126064920 T/A cg10911889 chr6:126070802 HEY2 0.38 5.7 0.3 2.73e-8 Brugada syndrome; CRC cis rs13161895 1.000 rs3797763 chr5:179439516 C/T cg02702477 chr5:179499311 RNF130 -0.56 -6.48 -0.34 3.35e-10 LDL cholesterol; CRC cis rs1971762 0.527 rs7972401 chr12:53940046 T/C cg06632207 chr12:54070931 ATP5G2 0.45 7.64 0.39 2.44e-13 Height; CRC cis rs1862618 0.853 rs866222 chr5:56184444 T/C cg24531977 chr5:56204891 C5orf35 -0.84 -10.92 -0.52 6.54e-24 Initial pursuit acceleration; CRC cis rs17767392 0.881 rs35054229 chr14:71785202 T/G cg13720639 chr14:72061746 SIPA1L1 -0.55 -6.95 -0.36 1.99e-11 Mitral valve prolapse; CRC cis rs3936840 0.752 rs2181343 chr14:102993303 A/C cg18135206 chr14:102964638 TECPR2 -0.59 -8.95 -0.44 2.61e-17 Plateletcrit; CRC trans rs11098499 0.644 rs2389880 chr4:120559870 T/A cg25214090 chr10:38739885 LOC399744 0.55 8.49 0.42 7.11e-16 Corneal astigmatism; CRC cis rs79349575 0.721 rs4794004 chr17:47038471 C/T cg22482690 chr17:47019901 SNF8 0.48 8.06 0.41 1.46e-14 Type 2 diabetes; CRC cis rs2075371 0.933 rs1868784 chr7:133945932 A/G cg02659138 chr7:134003124 SLC35B4 0.38 6.51 0.34 2.78e-10 Mean platelet volume; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg02504136 chr16:84698702 NA 0.38 5.96 0.31 6.5e-9 Liver disease severity in Alagille syndrome; CRC cis rs1865760 0.613 rs9358894 chr6:25923315 C/T cg03517284 chr6:25882590 NA -0.44 -6.56 -0.34 2.1e-10 Height; CRC cis rs911119 0.657 rs2104005 chr20:23630761 G/A cg16589663 chr20:23618590 CST3 0.6 7.12 0.37 6.91e-12 Chronic kidney disease; CRC cis rs13108904 0.967 rs13149715 chr4:1278255 C/A cg00684032 chr4:1343700 KIAA1530 0.49 7.25 0.37 3.04e-12 Obesity-related traits; CRC cis rs4789294 0.806 rs1466003 chr17:74435359 A/G cg06840243 chr17:74442338 UBE2O -0.42 -6.06 -0.32 3.79e-9 Lymphocyte percentage of white cells; CRC cis rs12711979 0.740 rs6715434 chr2:3820862 T/G cg17052675 chr2:3827356 NA -0.57 -10.83 -0.51 1.38e-23 Itch intensity from mosquito bite adjusted by bite size; CRC cis rs12142240 0.698 rs66516678 chr1:46810112 G/T cg00530320 chr1:46809349 NSUN4 0.58 7.98 0.4 2.46e-14 Menopause (age at onset); CRC cis rs7772486 0.686 rs9485019 chr6:146046381 C/G cg23711669 chr6:146136114 FBXO30 -0.66 -11.0 -0.52 3.68e-24 Lobe attachment (rater-scored or self-reported); CRC cis rs7680126 0.596 rs17198547 chr4:10141419 A/G cg00071950 chr4:10020882 SLC2A9 0.49 6.41 0.33 5.05e-10 Urate levels in lean individuals;Urate levels in overweight individuals;Urate levels in obese individuals; CRC cis rs798554 0.797 rs798488 chr7:2802522 T/C cg14895029 chr7:2775587 GNA12 -0.46 -6.69 -0.35 9.46e-11 Height; CRC cis rs427941 0.703 rs1637257 chr7:101740606 T/G cg06246474 chr7:101738831 CUX1 0.46 7.24 0.37 3.2e-12 Plasma omega-3 polyunsaturated fatty acid level (eicosapentaenoic acid); CRC cis rs4901869 0.966 rs4901868 chr14:59333792 C/T cg02291164 chr14:59296302 NA -0.35 -6.37 -0.33 6.35e-10 Panic disorder; CRC trans rs6550704 0.687 rs9865314 chr3:22634337 A/G cg16551326 chr19:42759518 ERF -0.41 -6.13 -0.32 2.49e-9 Daytime sleep phenotypes; CRC trans rs11098499 0.731 rs10015579 chr4:120271802 T/C cg25214090 chr10:38739885 LOC399744 0.53 8.51 0.42 6.28e-16 Corneal astigmatism; CRC cis rs7113874 0.569 rs7104646 chr11:8558841 G/T cg02811074 chr11:8615871 STK33 -0.36 -6.06 -0.32 3.69e-9 Body mass index in physically active individuals;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs12893668 0.603 rs61637848 chr14:104096031 C/T cg01849466 chr14:104193079 ZFYVE21 -0.41 -5.96 -0.31 6.63e-9 Reticulocyte count; CRC cis rs10751667 0.666 rs7395267 chr11:962326 C/A cg23136738 chr11:925521 AP2A2 -0.42 -7.09 -0.36 8.19e-12 Alzheimer's disease (late onset); CRC cis rs4478858 0.735 rs6681286 chr1:31799384 G/C cg00250761 chr1:31883323 NA -0.44 -8.5 -0.42 6.71e-16 Alcohol dependence; CRC cis rs9891119 0.602 rs3785898 chr17:40515120 G/T cg06270615 chr17:40516068 STAT3 -0.34 -7.41 -0.38 1.07e-12 Multiple sclerosis;Crohn's disease; CRC cis rs7618915 0.508 rs11717043 chr3:52656092 A/T cg18099408 chr3:52552593 STAB1 -0.43 -7.1 -0.36 7.92e-12 Bipolar disorder; CRC cis rs12024301 0.557 rs11802816 chr1:183654689 T/C cg11505048 chr1:183622726 RGL1;APOBEC4 0.71 6.24 0.33 1.33e-9 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs13064411 0.696 rs869343 chr3:113226705 C/T cg10517650 chr3:113235015 CCDC52 -0.41 -7.29 -0.37 2.4e-12 Response to simvastatin treatment (PCSK9 protein level change); CRC cis rs12145833 0.596 rs12043646 chr1:243281992 G/A cg02356786 chr1:243265016 LOC731275 0.79 6.08 0.32 3.39e-9 Obesity (early onset extreme); CRC cis rs6693567 0.565 rs3125808 chr1:150314272 T/C cg15654264 chr1:150340011 RPRD2 0.37 5.81 0.31 1.46e-8 Migraine; CRC trans rs1973993 0.691 rs1980683 chr1:96890379 A/G cg10631902 chr5:14652156 NA 0.56 10.99 0.52 4e-24 Weight; CRC cis rs995000 0.965 rs10889338 chr1:62984897 C/T cg19896129 chr1:63156450 NA 0.41 5.96 0.31 6.34e-9 Triglyceride levels; CRC cis rs611744 0.560 rs58605513 chr8:109279122 A/C cg18478394 chr8:109455254 TTC35 0.38 5.89 0.31 9.79e-9 Dupuytren's disease; CRC cis rs4819052 0.851 rs7276828 chr21:46695039 T/G cg02159808 chr21:46707872 POFUT2;LOC642852 0.51 6.72 0.35 8.21e-11 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs9487051 0.714 rs6902892 chr6:109627601 G/T cg01475377 chr6:109611718 NA -0.38 -6.75 -0.35 6.73e-11 Reticulocyte fraction of red cells; CRC cis rs3008870 1.000 rs11208979 chr1:67442275 C/T cg08660285 chr1:67390436 MIER1;WDR78 -1.04 -15.24 -0.64 4.66e-40 Lymphocyte percentage of white cells; CRC cis rs3858526 0.959 rs10838795 chr11:5920721 A/G cg26762873 chr11:5879799 OR52E8 0.39 5.82 0.31 1.39e-8 DNA methylation (variation); CRC cis rs4144743 0.759 rs4289057 chr17:45321030 G/A cg18085866 chr17:45331354 ITGB3 -0.53 -6.5 -0.34 2.9e-10 Body mass index; CRC cis rs2303759 0.918 rs7251704 chr19:49890873 T/G cg22133161 chr19:49891603 CCDC155 0.5 6.92 0.36 2.42e-11 Multiple sclerosis; CRC cis rs2243480 1.000 rs431318 chr7:65511597 G/A cg18252515 chr7:66147081 NA -1.19 -13.16 -0.59 4.5e-32 Diabetic kidney disease; CRC cis rs1878931 0.624 rs27241 chr16:3447282 C/G cg02880119 chr16:3481970 NA 0.42 5.93 0.31 7.75e-9 Body mass index (adult); CRC cis rs4713118 0.662 rs9468275 chr6:28026136 G/T cg15845792 chr6:28175446 NA 0.96 13.94 0.61 5.17e-35 Parkinson's disease; CRC cis rs7552404 0.731 rs11161845 chr1:76367559 T/C cg22875332 chr1:76189707 ACADM 0.63 7.67 0.39 2e-13 Blood metabolite levels;Acylcarnitine levels; CRC cis rs7618915 0.501 rs9917834 chr3:52634619 A/C cg18404041 chr3:52824283 ITIH1 -0.41 -8.61 -0.43 3.02e-16 Bipolar disorder; CRC cis rs1862618 0.671 rs2591968 chr5:56233541 A/G cg24531977 chr5:56204891 C5orf35 -0.7 -10.54 -0.5 1.4e-22 Initial pursuit acceleration; CRC cis rs870825 0.616 rs4263438 chr4:185624238 C/T cg04058563 chr4:185651563 MLF1IP 0.72 9.38 0.46 1.12e-18 Blood protein levels; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg22448308 chr15:81293687 MESDC1 0.51 7.05 0.36 1.07e-11 Anxiety disorder; CRC cis rs17270561 0.609 rs9366629 chr6:25741216 G/A cg17691542 chr6:26056736 HIST1H1C 0.72 9.24 0.45 3.07e-18 Iron status biomarkers; CRC cis rs7613875 0.620 rs7634441 chr3:50071677 G/A cg24110177 chr3:50126178 RBM5 0.58 9.12 0.45 7.38e-18 Body mass index; CRC cis rs3733585 0.682 rs13124563 chr4:9927553 A/G cg11266682 chr4:10021025 SLC2A9 0.5 9.96 0.48 1.39e-20 Cleft plate (environmental tobacco smoke interaction); CRC trans rs561341 0.714 rs75861674 chr17:30304317 A/G cg20587970 chr11:113659929 NA -1.18 -17.14 -0.69 1.57e-47 Hip circumference adjusted for BMI; CRC cis rs4926298 1.000 rs8104231 chr19:13159569 A/T cg11738485 chr19:12877000 HOOK2 -0.42 -5.83 -0.31 1.33e-8 Bipolar disorder; CRC cis rs11628318 0.803 rs10138267 chr14:103035432 C/T cg12046867 chr14:103022105 NA -0.83 -11.84 -0.55 3.52e-27 Platelet count; CRC cis rs73206853 0.764 rs73206857 chr12:110767721 T/A cg12870014 chr12:110450643 ANKRD13A 0.85 10.3 0.49 9.63e-22 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC cis rs453301 0.686 rs28482034 chr8:8869664 G/A cg14979609 chr8:8086686 FLJ10661 0.38 6.05 0.32 3.87e-9 Joint mobility (Beighton score); CRC cis rs250677 0.687 rs250673 chr5:148445798 C/T cg23229984 chr5:148520753 ABLIM3 0.5 6.95 0.36 1.96e-11 Breast cancer; CRC cis rs40363 0.645 rs1690447 chr16:3519211 T/C cg22508957 chr16:3507546 NAT15 0.65 9.92 0.48 1.82e-20 Tuberculosis; CRC cis rs763121 1.000 rs86796 chr22:38881454 A/C cg06022373 chr22:39101656 GTPBP1 -0.74 -11.78 -0.54 5.9e-27 Menopause (age at onset); CRC cis rs1799949 1.000 rs2037076 chr17:41305883 G/A cg01879757 chr17:41196368 BRCA1 -0.44 -6.72 -0.35 8.23e-11 Menopause (age at onset); CRC cis rs4665809 0.941 rs1434079 chr2:26284670 C/G cg25036284 chr2:26402008 FAM59B -0.46 -6.01 -0.31 4.86e-9 Gut microbiome composition (summer); CRC cis rs3733585 0.699 rs17245723 chr4:9962218 A/T cg11266682 chr4:10021025 SLC2A9 -0.47 -9.63 -0.47 1.71e-19 Cleft plate (environmental tobacco smoke interaction); CRC cis rs7659604 0.846 rs35986491 chr4:122664528 A/T cg06713675 chr4:122721982 EXOSC9 -0.38 -6.25 -0.33 1.26e-9 Type 2 diabetes; CRC cis rs10170846 0.893 rs1447108 chr2:223542231 A/G cg25565276 chr2:223520875 FARSB 0.54 7.49 0.38 6.25e-13 Schizophrenia (inflammation and infection response interaction); CRC trans rs1728785 1.000 rs1364109 chr16:68595505 T/C cg04657470 chr2:198365150 HSPE1;HSPD1 0.59 7.14 0.37 5.95e-12 Ulcerative colitis; CRC cis rs9409565 0.826 rs4612412 chr9:97208627 C/G cg04523069 chr9:97136363 HIATL1 0.36 5.61 0.3 4.33e-8 Colorectal cancer (alcohol consumption interaction); CRC cis rs7772486 0.754 rs4896838 chr6:146015451 T/C cg13319975 chr6:146136371 FBXO30 0.48 6.97 0.36 1.79e-11 Lobe attachment (rater-scored or self-reported); CRC cis rs7552404 0.727 rs6683437 chr1:76316619 G/A cg03433033 chr1:76189801 ACADM 0.69 8.83 0.44 6.19e-17 Blood metabolite levels;Acylcarnitine levels; CRC cis rs7618501 0.633 rs11925192 chr3:50038664 G/A cg24110177 chr3:50126178 RBM5 -0.44 -6.68 -0.35 1e-10 Intelligence (multi-trait analysis); CRC cis rs765787 0.530 rs12917187 chr15:45538297 A/G cg24006582 chr15:45444508 DUOX1 -0.57 -8.63 -0.43 2.62e-16 Uric acid levels; CRC cis rs73591976 0.539 rs12446198 chr16:68125972 G/A cg08314208 chr16:67682810 RLTPR -0.61 -6.45 -0.34 4e-10 HDL cholesterol; CRC cis rs2228479 0.850 rs62052714 chr16:89857180 T/C cg19635926 chr16:89946313 TCF25 0.65 6.09 0.32 3.17e-9 Skin colour saturation; CRC cis rs6964587 1.000 rs34548928 chr7:91668365 G/A cg17063962 chr7:91808500 NA 0.8 14.15 0.62 7.64e-36 Breast cancer; CRC trans rs7395662 1.000 rs4882017 chr11:48570182 C/T cg21153622 chr11:89784906 NA 0.48 7.68 0.39 1.83e-13 HDL cholesterol; CRC cis rs7618915 0.570 rs13068293 chr3:52672167 C/A cg08222913 chr3:52553049 STAB1 -0.34 -6.14 -0.32 2.4e-9 Bipolar disorder; CRC cis rs4237845 0.773 rs6650218 chr12:58289078 T/A cg00677455 chr12:58241039 CTDSP2 0.52 7.47 0.38 7.08e-13 Intelligence (multi-trait analysis); CRC cis rs4927850 0.752 rs7618864 chr3:195749561 G/A cg00031303 chr3:195681400 NA 0.52 7.52 0.38 5.33e-13 Pancreatic cancer; CRC cis rs8060686 0.920 rs2271293 chr16:67902070 A/G cg06138825 chr16:67683817 RLTPR 0.55 5.86 0.31 1.15e-8 HDL cholesterol;Metabolic syndrome; CRC cis rs780096 0.546 rs7563162 chr2:27631191 C/T cg12648201 chr2:27665141 KRTCAP3 -0.29 -5.8 -0.3 1.52e-8 Total body bone mineral density; CRC cis rs977987 0.835 rs11641532 chr16:75329480 T/C cg03315344 chr16:75512273 CHST6 0.52 8.9 0.44 3.96e-17 Dupuytren's disease; CRC cis rs12143943 0.934 rs4951406 chr1:204554603 A/G cg17419461 chr1:204415978 PIK3C2B 0.42 6.35 0.33 7.03e-10 Cognitive performance; CRC cis rs6456156 0.792 rs10946213 chr6:167516095 A/G cg07741184 chr6:167504864 NA -0.47 -8.29 -0.42 2.88e-15 Primary biliary cholangitis; CRC cis rs2386661 0.547 rs11259540 chr10:5646706 A/T cg02449762 chr10:5661741 NA -0.33 -5.8 -0.3 1.54e-8 Breast cancer; CRC cis rs2046867 0.862 rs62251646 chr3:72805787 T/C cg25664220 chr3:72788482 NA -0.45 -6.37 -0.33 6.34e-10 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; CRC cis rs13191362 1.000 rs34052221 chr6:163160803 G/A cg06582575 chr6:163149167 PACRG;PARK2 0.91 11.59 0.54 2.72e-26 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs801193 0.569 rs35070132 chr7:66238083 C/T cg11764359 chr7:65958608 NA 0.57 8.4 0.42 1.38e-15 Aortic root size; CRC cis rs7659604 1.000 rs6823488 chr4:122664819 A/G cg06713675 chr4:122721982 EXOSC9 -0.36 -5.64 -0.3 3.62e-8 Type 2 diabetes; CRC cis rs10392 0.516 rs3752293 chr20:37570725 A/G cg27552599 chr20:37590471 DHX35 -0.37 -5.63 -0.3 3.88e-8 Alcohol dependence or chronic alcoholic pancreatitis or alcohol-related liver cirrhosis; CRC cis rs908922 0.582 rs1856121 chr1:152512169 A/T cg23254163 chr1:152506842 NA 0.44 8.67 0.43 2.07e-16 Hair morphology; CRC cis rs7309 0.810 rs11684253 chr2:162034536 G/T cg13854012 chr2:162103682 NA -0.47 -7.61 -0.39 2.83e-13 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Educational attainment; CRC cis rs2239547 0.522 rs2581801 chr3:52972907 G/T cg18404041 chr3:52824283 ITIH1 0.34 6.39 0.33 5.78e-10 Schizophrenia; CRC cis rs4474465 0.688 rs7124803 chr11:78280822 T/G cg27205649 chr11:78285834 NARS2 0.53 7.01 0.36 1.32e-11 Alzheimer's disease (survival time); CRC cis rs10046574 0.831 rs10250306 chr7:135165275 G/A cg27474649 chr7:135195673 CNOT4 0.65 5.8 0.3 1.57e-8 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs875971 1.000 rs4717300 chr7:65947380 T/C cg18876405 chr7:65276391 NA 0.52 8.9 0.44 3.92e-17 Aortic root size; CRC cis rs9916302 0.851 rs11078904 chr17:37650569 G/A cg07936489 chr17:37558343 FBXL20 -0.84 -13.24 -0.59 2.32e-32 Glomerular filtration rate (creatinine); CRC cis rs290268 0.647 rs1333637 chr9:93557066 C/T cg02608019 chr9:93564028 SYK -0.45 -6.81 -0.35 4.66e-11 Platelet count; CRC trans rs17661538 0.685 rs2497809 chr10:18360244 A/G cg13235825 chr11:107574836 NA 0.49 6.01 0.31 4.99e-9 Response to antipsychotic treatment; CRC cis rs12760731 0.623 rs7530725 chr1:178385456 G/A cg00404053 chr1:178313656 RASAL2 0.77 9.0 0.44 1.83e-17 Obesity-related traits; CRC cis rs2153535 0.580 rs986060 chr6:8465428 T/C cg07606381 chr6:8435919 SLC35B3 0.68 10.9 0.51 8.26e-24 Motion sickness; CRC cis rs7843479 0.601 rs4872209 chr8:21848832 A/T cg16476235 chr8:21771668 DOK2 0.4 7.05 0.36 1.06e-11 Mean corpuscular volume; CRC cis rs7089973 0.604 rs765173 chr10:116601675 C/T cg23260525 chr10:116636907 FAM160B1 0.39 9.32 0.46 1.68e-18 Bipolar disorder or attention deficit hyperactivity disorder; CRC cis rs4665809 0.878 rs6720312 chr2:26364934 A/G cg27170947 chr2:26402098 FAM59B 0.49 6.06 0.32 3.79e-9 Gut microbiome composition (summer); CRC cis rs7692995 1.000 rs2125654 chr4:18025368 A/T cg08925142 chr4:18023851 LCORL -0.49 -5.76 -0.3 1.98e-8 Height; CRC cis rs1046896 0.553 rs2292965 chr17:80900645 G/A cg19500275 chr17:80737654 TBCD 0.49 6.73 0.35 7.36e-11 Glycated hemoglobin levels; CRC cis rs2075671 0.810 rs12531792 chr7:100280624 G/A cg00334542 chr7:100209784 MOSPD3 -0.55 -6.79 -0.35 5.14e-11 Other erythrocyte phenotypes; CRC cis rs10493773 0.609 rs3753789 chr1:86174814 T/C cg17807903 chr1:86174739 ZNHIT6 -0.65 -17.77 -0.7 5.54e-50 Urate levels in overweight individuals; CRC cis rs9926296 0.548 rs12447465 chr16:89829895 C/T cg03388025 chr16:89894329 SPIRE2 0.42 8.29 0.42 2.98e-15 Vitiligo; CRC cis rs4665809 0.838 rs2243834 chr2:26357748 A/C cg26119090 chr2:26468346 HADHA;HADHB 0.63 8.18 0.41 6.06e-15 Gut microbiome composition (summer); CRC cis rs561341 0.882 rs504887 chr17:30322881 T/A cg19193384 chr17:30244184 NA -0.57 -7.05 -0.36 1.09e-11 Hip circumference adjusted for BMI; CRC cis rs2836974 0.897 rs3945 chr21:40566067 A/G cg07074390 chr21:40555500 PSMG1 -0.46 -6.2 -0.32 1.7e-9 Cognitive function; CRC cis rs2742417 0.967 rs2742441 chr3:45748429 G/A cg04837898 chr3:45731254 SACM1L -0.36 -5.92 -0.31 7.98e-9 Response to anti-depressant treatment in major depressive disorder; CRC cis rs754466 0.580 rs2289311 chr10:79565655 G/A cg26805224 chr10:79626177 DLG5 -0.45 -6.69 -0.35 9.47e-11 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs9649213 0.593 rs7781916 chr7:97929738 A/G cg21770322 chr7:97807741 LMTK2 0.5 8.23 0.41 4.39e-15 Prostate cancer (SNP x SNP interaction); CRC cis rs7731657 0.537 rs4706002 chr5:130373830 C/T cg08523029 chr5:130500466 HINT1 -0.45 -5.85 -0.31 1.18e-8 Fasting plasma glucose; CRC trans rs57221529 0.766 rs12521051 chr5:560440 A/G cg11887960 chr12:57824829 NA -0.58 -6.39 -0.33 5.75e-10 Lung disease severity in cystic fibrosis; CRC cis rs9826463 0.582 rs7633870 chr3:142118914 A/G cg20824294 chr3:142316082 PLS1 0.36 5.9 0.31 9.06e-9 QRS duration in Tripanosoma cruzi seropositivity; CRC cis rs561341 0.941 rs2470236 chr17:30304940 G/C cg23018236 chr17:30244563 NA -0.58 -7.7 -0.39 1.64e-13 Hip circumference adjusted for BMI; CRC cis rs1129187 0.934 rs9471974 chr6:42918984 T/A cg02359409 chr6:42947317 PEX6 -0.57 -8.96 -0.44 2.41e-17 Alzheimer's disease in APOE e4+ carriers; CRC cis rs10504229 0.906 rs66480865 chr8:58187100 C/T cg02290350 chr8:58132656 NA -0.42 -5.96 -0.31 6.62e-9 Developmental language disorder (linguistic errors); CRC cis rs7412746 0.658 rs1027699 chr1:150811712 T/C cg18016565 chr1:150552671 MCL1 0.42 5.88 0.31 1e-8 Melanoma; CRC cis rs7811142 0.830 rs75636500 chr7:99947657 C/G cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.14 14.99 0.64 4.31e-39 Platelet count; CRC cis rs3091242 0.933 rs28633797 chr1:25741629 C/A cg20684491 chr1:25596433 NA 0.41 7.0 0.36 1.44e-11 Erythrocyte sedimentation rate; CRC cis rs6502050 0.799 rs8066370 chr17:80102105 T/C cg13198984 chr17:80129470 CCDC57 0.46 8.16 0.41 6.94e-15 Life satisfaction; CRC cis rs6496667 0.779 rs8039719 chr15:90958584 C/G cg04176472 chr15:90893244 GABARAPL3 0.6 7.72 0.39 1.45e-13 Rheumatoid arthritis; CRC cis rs1179624 0.679 rs4731231 chr7:75264463 A/G cg05145297 chr7:75264568 HIP1 0.6 8.19 0.41 5.83e-15 Age-related nuclear cataracts; CRC cis rs7659604 0.502 rs10013916 chr4:122702179 T/G cg19748678 chr4:122722346 EXOSC9 -0.43 -5.81 -0.31 1.44e-8 Type 2 diabetes; CRC cis rs12594515 1.000 rs8031128 chr15:45988528 C/G cg19682013 chr15:45996608 NA 0.32 6.7 0.35 9.09e-11 Waist circumference;Weight; CRC cis rs6952808 0.782 rs4236271 chr7:1881369 C/T cg04267008 chr7:1944627 MAD1L1 -0.59 -8.81 -0.44 7.09e-17 Bipolar disorder and schizophrenia; CRC cis rs6582630 0.519 rs10880629 chr12:38533611 T/G cg13010199 chr12:38710504 ALG10B 0.49 6.55 0.34 2.17e-10 Drug-induced liver injury (flucloxacillin); CRC cis rs10751667 0.643 rs7396407 chr11:929374 A/T cg01483505 chr11:975446 AP2A2 0.43 6.87 0.35 3.26e-11 Alzheimer's disease (late onset); CRC cis rs896854 0.654 rs4735340 chr8:95976251 A/T cg23172400 chr8:95962367 TP53INP1 -0.49 -8.19 -0.41 5.96e-15 Type 2 diabetes; CRC cis rs12594515 0.967 rs11070465 chr15:45984899 A/G cg19682013 chr15:45996608 NA 0.35 7.16 0.37 5.19e-12 Waist circumference;Weight; CRC cis rs8062405 0.824 rs7191618 chr16:28565667 C/G cg05139728 chr16:28306816 SBK1 -0.34 -5.82 -0.31 1.4e-8 Cognitive ability (multi-trait analysis);Cognitive ability; CRC trans rs208520 0.690 rs4386800 chr6:66755242 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 1.04 14.77 0.63 3.19e-38 Exhaled nitric oxide output; CRC cis rs6582630 0.533 rs2120464 chr12:38280289 A/C cg13010199 chr12:38710504 ALG10B 0.4 5.74 0.3 2.13e-8 Drug-induced liver injury (flucloxacillin); CRC trans rs12599106 0.839 rs3853177 chr16:34498532 A/G cg07332563 chr6:291687 DUSP22 -0.47 -6.66 -0.34 1.17e-10 Menopause (age at onset); CRC cis rs2952156 0.920 rs1565920 chr17:37831613 G/A cg11212589 chr17:38028394 ZPBP2 0.35 6.08 0.32 3.24e-9 Asthma; CRC cis rs6500602 0.964 rs13335685 chr16:4469284 T/C cg08645402 chr16:4508243 NA 0.57 9.46 0.46 6.22e-19 Schizophrenia; CRC trans rs6703335 0.870 rs10803142 chr1:243598234 A/G cg02021460 chr16:19729639 C16orf88;IQCK 0.46 6.44 0.33 4.12e-10 Schizophrenia;Schizophrenia, schizoaffective disorder or bipolar disorder; CRC cis rs4363385 0.588 rs1577960 chr1:153025687 G/A cg25856811 chr1:152973957 SPRR3 -0.23 -6.44 -0.33 4.29e-10 Inflammatory skin disease; CRC cis rs4820539 0.966 rs5996470 chr22:23483255 G/A cg14186256 chr22:23484241 RTDR1 0.92 18.5 0.71 7.1e-53 Bone mineral density; CRC cis rs7121446 0.521 rs12293988 chr11:121852633 C/T cg13820391 chr11:121835505 NA 0.31 5.78 0.3 1.72e-8 Cardiovascular risk factors (age interaction); CRC cis rs8031584 0.958 rs3512 chr15:31235005 G/C cg08109568 chr15:31115862 NA -0.55 -8.81 -0.44 7.52e-17 Huntington's disease progression; CRC cis rs9648716 1.000 rs4140846 chr7:140509716 T/C cg10747023 chr7:140774559 NA 0.44 5.8 0.3 1.52e-8 Type 2 diabetes; CRC cis rs1799949 1.000 rs8176126 chr17:41259049 A/G cg01879757 chr17:41196368 BRCA1 0.43 6.54 0.34 2.36e-10 Menopause (age at onset); CRC cis rs2040771 0.740 rs9605960 chr22:19214636 G/C cg02655711 chr22:19163373 SLC25A1 0.52 8.54 0.43 5.16e-16 Metabolite levels (small molecules and protein measures); CRC cis rs769267 0.930 rs4808959 chr19:19572108 T/G cg01262667 chr19:19385393 TM6SF2 0.36 5.91 0.31 8.43e-9 Tonsillectomy; CRC cis rs898097 0.841 rs4986122 chr17:80825500 C/T cg19046167 chr17:80928561 B3GNTL1 -0.47 -7.51 -0.38 5.78e-13 Breast cancer; CRC cis rs9910055 0.529 rs425038 chr17:42182028 T/C cg10896456 chr17:42255109 ASB16;C17orf65 -0.4 -6.22 -0.32 1.5e-9 Total body bone mineral density; CRC cis rs4862750 0.874 rs6822062 chr4:187895553 T/C cg06074448 chr4:187884817 NA -0.59 -10.89 -0.51 8.72e-24 Lobe attachment (rater-scored or self-reported); CRC cis rs7666738 0.830 rs7672127 chr4:98938477 A/G cg05340658 chr4:99064831 C4orf37 0.6 9.26 0.45 2.62e-18 Colonoscopy-negative controls vs population controls; CRC cis rs9914988 0.943 rs2043031 chr17:27085564 A/G cg07195577 chr17:27052828 TLCD1 0.42 6.08 0.32 3.28e-9 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs4561483 0.734 rs33655 chr16:11970381 C/T cg08843971 chr16:11963173 GSPT1 -0.64 -9.99 -0.48 1.03e-20 Testicular germ cell tumor; CRC cis rs155076 1.000 rs58519241 chr13:21845006 C/A cg25811766 chr13:21894605 NA -0.56 -5.86 -0.31 1.13e-8 White matter hyperintensity burden; CRC cis rs763121 0.819 rs5750629 chr22:38985065 T/C cg06544989 chr22:39130855 UNC84B 0.47 7.49 0.38 6.43e-13 Menopause (age at onset); CRC cis rs2549003 1.000 rs6873426 chr5:131818631 G/T cg00255919 chr5:131827918 IRF1 0.59 11.88 0.55 2.57e-27 Asthma (sex interaction); CRC cis rs12900413 0.687 rs28650972 chr15:90311941 C/T cg24249390 chr15:90295951 MESP1 -0.58 -9.27 -0.46 2.53e-18 Coronary artery aneurysm in Kawasaki disease; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg25471478 chr19:3721572 NA 0.37 6.1 0.32 3.05e-9 Liver disease severity in Alagille syndrome; CRC cis rs1555322 0.530 rs2425042 chr20:33865895 G/A cg03689076 chr20:33865952 NA 0.58 7.63 0.39 2.48e-13 Attention deficit hyperactivity disorder; CRC cis rs6570726 0.791 rs1509214 chr6:145784606 A/C cg23711669 chr6:146136114 FBXO30 -0.69 -11.92 -0.55 1.77e-27 Lobe attachment (rater-scored or self-reported); CRC cis rs9494145 0.648 rs9373124 chr6:135423209 T/C cg22676075 chr6:135203613 NA 0.44 5.78 0.3 1.71e-8 Mean platelet volume;Platelet count;Fetal hemoglobin levels in sickle cell anemia;Red blood cell traits; CRC cis rs9911578 0.835 rs2301867 chr17:56480074 T/A cg12560992 chr17:57184187 TRIM37 -0.84 -14.71 -0.63 5.58e-38 Intelligence (multi-trait analysis); CRC cis rs9649465 1.000 rs6950659 chr7:123361910 C/T cg03229431 chr7:123269106 ASB15 -0.36 -5.67 -0.3 3.21e-8 Migraine; CRC cis rs561341 1.000 rs484175 chr17:30309041 G/A cg12193833 chr17:30244370 NA -0.75 -8.8 -0.44 7.92e-17 Hip circumference adjusted for BMI; CRC trans rs10504229 1.000 rs58053450 chr8:58173348 T/C cg04077850 chr5:125800366 GRAMD3 0.37 6.27 0.33 1.15e-9 Developmental language disorder (linguistic errors); CRC cis rs67478160 0.643 rs2223937 chr14:104286380 A/G cg08213375 chr14:104286397 PPP1R13B 0.64 13.51 0.6 2.23e-33 Schizophrenia; CRC cis rs11585357 0.895 rs72633823 chr1:17630779 G/A cg08277548 chr1:17600880 PADI3 -0.87 -11.17 -0.52 8.7e-25 Hair shape; CRC cis rs11997175 0.646 rs7005018 chr8:33700210 A/G cg04338863 chr8:33670619 NA 0.43 6.76 0.35 6.28e-11 Body mass index; CRC cis rs758324 0.947 rs253943 chr5:131320730 C/T cg06307176 chr5:131281290 NA 0.4 6.0 0.31 5.26e-9 Alzheimer's disease in APOE e4- carriers; CRC cis rs2197308 0.565 rs12809769 chr12:37909968 C/T cg26384229 chr12:38710491 ALG10B 0.67 8.82 0.44 6.9e-17 Morning vs. evening chronotype; CRC cis rs155076 1.000 rs658244 chr13:21850976 T/C cg25811766 chr13:21894605 NA -0.59 -6.13 -0.32 2.49e-9 White matter hyperintensity burden; CRC cis rs2228479 0.702 rs17233441 chr16:89817998 C/G cg06558623 chr16:89946397 TCF25 1.15 10.8 0.51 1.85e-23 Skin colour saturation; CRC cis rs6963495 0.745 rs73192151 chr7:105211876 A/G cg02135003 chr7:105160482 PUS7 -0.93 -12.36 -0.56 4.2e-29 Bipolar disorder (body mass index interaction); CRC cis rs9733 0.566 rs72702554 chr1:150678234 A/G cg17724175 chr1:150552817 MCL1 0.59 9.37 0.46 1.18e-18 Tonsillectomy; CRC cis rs9309473 1.000 rs6711033 chr2:73746643 T/C cg20560298 chr2:73613845 ALMS1 -0.49 -6.04 -0.32 4.12e-9 Metabolite levels; CRC cis rs7917772 0.636 rs4919676 chr10:104524352 C/T cg22532475 chr10:104410764 TRIM8 0.33 5.62 0.3 4e-8 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC cis rs4862750 0.914 rs6814259 chr4:187872337 T/C cg11301795 chr4:187892539 NA -0.84 -18.03 -0.71 4.84e-51 Lobe attachment (rater-scored or self-reported); CRC trans rs34421088 0.560 rs2248316 chr8:11397073 A/C cg06636001 chr8:8085503 FLJ10661 -0.52 -7.72 -0.39 1.4e-13 Neuroticism; CRC cis rs8060686 0.516 rs2290699 chr16:68289059 C/T cg26727032 chr16:67993705 SLC12A4 -0.63 -8.64 -0.43 2.43e-16 HDL cholesterol;Metabolic syndrome; CRC cis rs6500602 0.647 rs4785967 chr16:4523208 G/A cg14951292 chr16:4525986 HMOX2;NMRAL1 0.53 7.74 0.39 1.22e-13 Schizophrenia; CRC cis rs929354 0.772 rs1182365 chr7:157017255 A/T cg17757837 chr7:157058334 UBE3C -0.76 -12.9 -0.58 4.36e-31 Body mass index; CRC cis rs6921919 0.789 rs1119211 chr6:28309136 C/G cg15845792 chr6:28175446 NA -0.44 -5.66 -0.3 3.37e-8 Autism spectrum disorder or schizophrenia; CRC cis rs12824058 0.831 rs1390849 chr12:130811547 A/G cg26677194 chr12:130822605 PIWIL1 0.45 7.19 0.37 4.42e-12 Menopause (age at onset); CRC cis rs10504229 0.775 rs10504228 chr8:58162053 T/G cg22535103 chr8:58192502 C8orf71 -0.71 -8.46 -0.42 8.68e-16 Developmental language disorder (linguistic errors); CRC cis rs3796352 1.000 rs3097417 chr3:53088601 C/G cg06204229 chr3:52865917 ITIH4 -0.47 -5.9 -0.31 9.19e-9 Immune reponse to smallpox (secreted IL-2); CRC cis rs1950626 0.750 rs35683125 chr14:101454750 T/C cg02351406 chr14:101447389 SNORD114-20;SNORD114-21 0.97 15.89 0.66 1.42e-42 Pelvic organ prolapse (moderate/severe); CRC cis rs2302190 1.000 rs8065388 chr17:56562132 C/T cg12560992 chr17:57184187 TRIM37 0.49 6.01 0.31 4.93e-9 Vitamin D levels; CRC cis rs11098499 0.754 rs10212714 chr4:120254302 T/C cg24375607 chr4:120327624 NA 0.48 7.42 0.38 1e-12 Corneal astigmatism; CRC cis rs3018066 0.867 rs4307042 chr4:107067830 C/G cg01869342 chr4:106983673 TBCK 0.37 5.72 0.3 2.43e-8 Cancer; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg00056719 chr12:53845867 PCBP2 0.48 6.59 0.34 1.77e-10 Anxiety disorder; CRC cis rs3771570 0.901 rs55811034 chr2:242406245 C/T cg21155796 chr2:242212141 HDLBP 0.63 6.8 0.35 4.92e-11 Prostate cancer; CRC cis rs1005277 0.579 rs1740747 chr10:38520465 G/A cg17219203 chr10:38645113 HSD17B7P2 -0.41 -5.92 -0.31 8.11e-9 Extrinsic epigenetic age acceleration; CRC cis rs2404602 0.716 rs67204011 chr15:76846555 C/T cg23625390 chr15:77176239 SCAPER 0.47 6.85 0.35 3.61e-11 Blood metabolite levels; CRC cis rs7772486 0.686 rs1292336 chr6:145967818 T/C cg23711669 chr6:146136114 FBXO30 -0.65 -10.73 -0.51 3.01e-23 Lobe attachment (rater-scored or self-reported); CRC cis rs11212617 0.967 rs228589 chr11:108093208 A/T cg14761454 chr11:108092087 ATM;NPAT 0.42 6.4 0.33 5.22e-10 Response to metformin in type 2 diabetes (glycemic); CRC cis rs2692947 0.550 rs4613327 chr2:96583823 G/A cg23100626 chr2:96804247 ASTL 0.27 7.11 0.36 7.42e-12 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; CRC cis rs7769051 0.803 rs56148066 chr6:133230115 G/A cg22852734 chr6:133119734 C6orf192 0.9 10.33 0.49 7.81e-22 Type 2 diabetes nephropathy; CRC cis rs875971 1.000 rs778722 chr7:65844828 T/C cg12463550 chr7:65579703 CRCP 0.48 6.96 0.36 1.89e-11 Aortic root size; CRC cis rs1364705 1.000 rs1364705 chr8:120224806 C/T cg27215916 chr8:120218354 NA 0.45 6.3 0.33 9.68e-10 Hippocampal atrophy; CRC cis rs9323205 0.954 rs9672122 chr14:51582391 A/G cg23942311 chr14:51606299 NA -0.54 -6.25 -0.33 1.25e-9 Cancer; CRC cis rs16975963 0.843 rs73041004 chr19:38263430 T/C cg15135657 chr19:38346511 NA -0.44 -5.9 -0.31 9.09e-9 Longevity; CRC cis rs6496044 0.963 rs11853972 chr15:86062440 A/G cg17133734 chr15:86042851 AKAP13 0.4 6.12 0.32 2.65e-9 Interstitial lung disease; CRC cis rs1568889 0.838 rs10458896 chr11:28057957 T/C cg06544937 chr11:28130018 METT5D1;KIF18A 0.91 15.25 0.64 4.49e-40 Bipolar disorder; CRC cis rs73206853 0.764 rs73206878 chr12:110835015 A/C cg12870014 chr12:110450643 ANKRD13A 0.8 7.66 0.39 2.05e-13 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC cis rs9916302 0.706 rs903507 chr17:37726423 A/G cg15445000 chr17:37608096 MED1 0.37 6.39 0.33 5.68e-10 Glomerular filtration rate (creatinine); CRC cis rs7618915 0.571 rs34954168 chr3:52612159 C/T cg15147215 chr3:52552868 STAB1 -0.63 -10.52 -0.5 1.72e-22 Bipolar disorder; CRC trans rs61931739 0.500 rs11513287 chr12:34584351 G/A cg26384229 chr12:38710491 ALG10B 0.67 8.7 0.43 1.61e-16 Morning vs. evening chronotype; CRC cis rs9549328 0.670 rs2993344 chr13:113617022 C/T cg24588162 chr13:113633484 MCF2L 0.36 6.56 0.34 2.08e-10 Systolic blood pressure; CRC cis rs12479064 0.671 rs62155807 chr2:100076579 G/A cg26064155 chr2:99771622 LIPT1;TSGA10 -0.63 -7.41 -0.38 1.09e-12 Chronic sinus infection; CRC cis rs72781680 0.611 rs56326157 chr2:24312407 T/C cg06627628 chr2:24431161 ITSN2 -0.54 -6.22 -0.32 1.51e-9 Lymphocyte counts; CRC cis rs34375054 0.660 rs900411 chr12:125612839 C/T cg06287003 chr12:125626642 AACS -0.52 -7.43 -0.38 9.35e-13 Post bronchodilator FEV1/FVC ratio; CRC cis rs7727544 1.000 rs10076701 chr5:131596419 A/G cg04518342 chr5:131593106 PDLIM4 0.39 7.54 0.38 4.68e-13 Blood metabolite levels; CRC cis rs67311347 0.544 rs2887965 chr3:40334154 A/G cg09455208 chr3:40491958 NA -0.31 -6.36 -0.33 6.79e-10 Renal cell carcinoma; CRC cis rs7786808 0.707 rs11770299 chr7:158228822 G/A cg01191920 chr7:158217561 PTPRN2 -0.91 -17.93 -0.7 1.21e-50 Obesity-related traits; CRC cis rs7945705 0.967 rs10769968 chr11:8907583 G/C cg14711859 chr11:8959438 ASCL3 -0.49 -8.11 -0.41 1.05e-14 Hemoglobin concentration; CRC cis rs4862750 0.872 rs4862747 chr4:187877236 A/T cg03452623 chr4:187889614 NA 0.89 20.92 0.76 2.13e-62 Lobe attachment (rater-scored or self-reported); CRC cis rs11148252 0.595 rs9526968 chr13:53240183 T/C cg20354231 chr13:53171401 NA -0.43 -6.87 -0.35 3.22e-11 Lewy body disease; CRC cis rs644799 0.965 rs573758 chr11:95539591 G/T cg03916912 chr11:95522834 CEP57;FAM76B 0.95 18.15 0.71 1.71e-51 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs2019137 0.560 rs11123172 chr2:113984303 C/T cg21482265 chr2:113992762 PAX8;LOC440839;LOC654433 -0.6 -9.28 -0.46 2.4e-18 Lymphocyte counts; CRC cis rs2535633 0.631 rs2257216 chr3:52968726 T/C cg11645453 chr3:52864694 ITIH4 -0.4 -7.43 -0.38 9.61e-13 Body mass index; CRC cis rs1878931 0.582 rs4785933 chr16:3419741 T/A cg02880119 chr16:3481970 NA -0.43 -6.05 -0.32 4e-9 Body mass index (adult); CRC cis rs17376456 0.877 rs2290937 chr5:93356515 A/T cg21475434 chr5:93447410 FAM172A 0.7 7.87 0.4 5.11e-14 Diabetic retinopathy; CRC cis rs10504229 0.593 rs16921589 chr8:58024387 C/A cg21724239 chr8:58056113 NA 0.58 7.75 0.39 1.17e-13 Developmental language disorder (linguistic errors); CRC cis rs6500395 1.000 rs904818 chr16:48622582 T/C cg04672837 chr16:48644449 N4BP1 0.44 6.6 0.34 1.69e-10 Response to tocilizumab in rheumatoid arthritis; CRC cis rs6032067 1.000 rs6032042 chr20:43815949 T/C cg10761708 chr20:43804764 PI3 0.5 5.68 0.3 2.93e-8 Blood protein levels; CRC cis rs2836950 0.805 rs2836961 chr21:40627020 A/C cg11890956 chr21:40555474 PSMG1 -0.52 -6.84 -0.35 3.98e-11 Menarche (age at onset); CRC cis rs10461617 0.617 rs79742142 chr5:56104377 A/G cg24531977 chr5:56204891 C5orf35 -0.84 -11.22 -0.53 5.99e-25 Type 2 diabetes; CRC cis rs2732480 0.577 rs2732486 chr12:48737834 G/A cg24011408 chr12:48396354 COL2A1 0.47 6.36 0.33 6.59e-10 Hemoglobin concentration;Red blood cell count;Hematocrit; CRC cis rs7605827 0.930 rs6719652 chr2:15571679 T/G cg19274914 chr2:15703543 NA 0.37 5.67 0.3 3.19e-8 Educational attainment (years of education); CRC cis rs9811920 0.638 rs2452321 chr3:99638836 T/C cg07805332 chr3:99536008 MIR548G;C3orf26 -0.54 -8.19 -0.41 5.93e-15 Axial length; CRC cis rs28386778 0.897 rs2036911 chr17:61794839 A/T cg22520471 chr17:61851767 DDX42;CCDC47 0.73 11.13 0.52 1.19e-24 Prudent dietary pattern; CRC cis rs7666738 0.830 rs11735193 chr4:98761900 C/T cg05340658 chr4:99064831 C4orf37 0.54 8.0 0.4 2.21e-14 Colonoscopy-negative controls vs population controls; CRC cis rs644799 1.000 rs568668 chr11:95528209 G/A cg25622487 chr11:95524042 FAM76B;CEP57 0.76 11.83 0.55 3.79e-27 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs1218582 0.745 rs1580943 chr1:154865125 G/A cg24250549 chr1:154909240 PMVK 0.64 10.87 0.51 1.02e-23 Prostate cancer; CRC cis rs2153535 0.580 rs2184586 chr6:8474182 A/G cg07606381 chr6:8435919 SLC35B3 0.68 10.9 0.51 8.26e-24 Motion sickness; CRC cis rs2811415 0.597 rs9845369 chr3:127743443 G/C cg13719885 chr3:127795394 NA -0.36 -5.62 -0.3 4.1e-8 Lung function (FEV1/FVC); CRC cis rs13144136 0.687 rs11726388 chr4:10660245 G/A cg10242279 chr4:10666415 CLNK -0.36 -6.21 -0.32 1.58e-9 Resistance to antihypertensive treatment in hypertension; CRC cis rs9322193 0.886 rs2065663 chr6:150081467 A/G cg13206674 chr6:150067644 NUP43 0.67 9.45 0.46 6.71e-19 Lung cancer; CRC trans rs6550704 0.687 rs9865314 chr3:22634337 A/G cg14489649 chr17:40021376 KLHL11 -0.46 -6.81 -0.35 4.61e-11 Daytime sleep phenotypes; CRC cis rs7255436 0.931 rs7249520 chr19:8446056 G/A cg10174797 chr19:8464628 RAB11B 0.44 7.51 0.38 5.6e-13 HDL cholesterol; CRC cis rs4713118 0.662 rs175954 chr6:28011585 A/G cg21251018 chr6:28226885 NKAPL 0.45 6.62 0.34 1.43e-10 Parkinson's disease; CRC cis rs7224737 1.000 rs35184688 chr17:40272406 G/C cg02228675 chr17:40259724 DHX58 -0.49 -6.91 -0.36 2.6e-11 Fibrinogen levels; CRC cis rs7827545 1.000 rs7463007 chr8:135567143 C/T cg17885191 chr8:135476712 NA 0.53 7.47 0.38 7.13e-13 Hypertension (SNP x SNP interaction); CRC trans rs10983614 1.000 rs7867776 chr9:120072627 A/G cg22812733 chr3:58571389 NA 0.44 5.99 0.31 5.48e-9 Survival in pancreatic cancer; CRC cis rs1107366 1.000 rs9873704 chr3:125901902 G/C cg21601837 chr3:125900065 ALDH1L1 -0.36 -5.97 -0.31 6.03e-9 Metabolite levels; CRC trans rs951252 0.504 rs11734405 chr4:146081096 C/T cg25940730 chr4:16228647 TAPT1;FLJ39653 0.47 6.15 0.32 2.29e-9 Hip circumference; CRC cis rs3762318 1.000 rs12069782 chr1:67600101 C/T cg17031739 chr1:67600172 NA 0.48 6.0 0.31 5.13e-9 Leprosy; CRC cis rs11711311 1.000 rs9809850 chr3:113429010 C/T cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.53 -6.94 -0.36 2.12e-11 IgG glycosylation; CRC trans rs2172802 0.638 rs7675385 chr4:62502229 A/G cg25787300 chr7:101599518 CUX1 -0.43 -5.98 -0.31 5.92e-9 Partial epilepsies; CRC trans rs8123881 0.733 rs7268466 chr20:15810676 C/T cg03674076 chr20:524243 CSNK2A1 0.55 6.16 0.32 2.11e-9 Body mass index; CRC cis rs17401966 0.540 rs6541084 chr1:10285447 A/G cg19773385 chr1:10388646 KIF1B -0.48 -7.46 -0.38 7.55e-13 Hepatocellular carcinoma; CRC cis rs12594515 1.000 rs6493167 chr15:45986809 G/A cg06207120 chr15:45996521 NA 0.32 7.85 0.4 6.04e-14 Waist circumference;Weight; CRC cis rs9527 0.615 rs11191489 chr10:104740568 C/A cg15744005 chr10:104629667 AS3MT -0.31 -6.11 -0.32 2.74e-9 Arsenic metabolism; CRC cis rs883565 0.655 rs4676628 chr3:39095965 G/A cg01426195 chr3:39028469 NA -0.54 -8.77 -0.44 9.85e-17 Handedness; CRC cis rs73200209 0.912 rs55841728 chr12:116645455 C/A cg01776926 chr12:116560359 MED13L -0.48 -5.81 -0.31 1.48e-8 Total body bone mineral density; CRC cis rs548181 0.545 rs76179820 chr11:125616379 A/G cg03464685 chr11:125439445 EI24 -0.98 -10.81 -0.51 1.68e-23 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs13343954 0.518 rs8106293 chr19:33536376 C/T cg27124370 chr19:33622961 WDR88 0.47 7.15 0.37 5.64e-12 Colorectal cancer; CRC cis rs6724607 1.000 rs11680758 chr2:191446268 T/G cg27211696 chr2:191398769 TMEM194B 0.39 5.89 0.31 9.46e-9 Pulse pressure; CRC cis rs7119 0.623 rs11637932 chr15:77847353 T/G cg27398640 chr15:77910606 LINGO1 -0.4 -6.71 -0.35 8.58e-11 Type 2 diabetes; CRC cis rs28386778 0.863 rs2727355 chr17:61931790 C/T cg25654072 chr17:61904446 PSMC5;FTSJ3 0.69 10.71 0.51 3.81e-23 Prudent dietary pattern; CRC trans rs7873102 0.702 rs7028020 chr9:38007747 C/T cg03383789 chr16:5148781 FAM86A -0.36 -5.98 -0.31 5.92e-9 Brain structure; CRC cis rs9427116 0.502 rs9427100 chr1:154583762 G/A cg24304309 chr1:154577895 ADAR 0.34 5.6 0.3 4.5e-8 Blood protein levels; CRC trans rs2014572 0.967 rs10413037 chr19:57771883 A/G cg02674126 chr19:40336878 FBL 0.39 6.22 0.32 1.47e-9 Hyperactive-impulsive symptoms; CRC cis rs149866169 1 rs149866169 chr6:27441723 T/A cg12273811 chr6:28175739 NA 0.68 5.65 0.3 3.46e-8 Neuroticism (multi-trait analysis);Lung cancer in ever smokers;Subjective well-being (multi-trait analysis);Lung cancer;Squamous cell lung carcinoma; CRC cis rs1005277 0.505 rs10827836 chr10:38215441 A/G cg25427524 chr10:38739819 LOC399744 0.76 13.19 0.59 3.51e-32 Extrinsic epigenetic age acceleration; CRC cis rs477895 0.713 rs11607165 chr11:63963947 T/G cg05016508 chr11:63871570 FLRT1;MACROD1 0.54 6.94 0.36 2.08e-11 Mean platelet volume; CRC cis rs4975616 0.804 rs31489 chr5:1342714 C/A cg06550200 chr5:1325588 CLPTM1L -0.72 -11.63 -0.54 2.05e-26 Lung cancer; CRC cis rs7772486 0.658 rs9403737 chr6:145962193 G/T cg13319975 chr6:146136371 FBXO30 -0.46 -6.78 -0.35 5.54e-11 Lobe attachment (rater-scored or self-reported); CRC cis rs9611565 0.625 rs73178625 chr22:41928320 G/C cg17554472 chr22:41940697 POLR3H -0.54 -5.88 -0.31 1.02e-8 Vitiligo; CRC cis rs910316 0.967 rs2024653 chr14:75595154 G/A cg08847533 chr14:75593920 NEK9 0.93 17.49 0.69 6.56e-49 Height; CRC cis rs76878669 0.561 rs7105015 chr11:66159390 A/G cg24851651 chr11:66362959 CCS -0.34 -5.64 -0.3 3.69e-8 Educational attainment (years of education); CRC cis rs9341808 0.935 rs2322633 chr6:80845989 C/T cg08355045 chr6:80787529 NA -0.37 -6.4 -0.33 5.36e-10 Sitting height ratio; CRC cis rs10256972 0.616 rs4585652 chr7:1145396 A/G cg03188948 chr7:1209495 NA 0.45 6.37 0.33 6.4e-10 Longevity;Endometriosis; CRC cis rs9491140 0.539 rs980657 chr6:124690330 C/T cg19267163 chr6:125004984 NKAIN2 0.42 5.71 0.3 2.51e-8 Neuroticism; CRC cis rs12134245 0.747 rs11164912 chr1:92005191 A/T cg02896835 chr1:92012615 NA -0.65 -11.79 -0.54 5.53e-27 Breast cancer; CRC cis rs9292777 0.748 rs12519453 chr5:40387173 G/A cg09067459 chr5:40385259 NA -0.56 -9.28 -0.46 2.31e-18 Crohn's disease;Multiple sclerosis; CRC cis rs3749237 0.595 rs7621003 chr3:49411404 T/C cg03060546 chr3:49711283 APEH 0.6 10.25 0.49 1.36e-21 Resting heart rate; CRC cis rs736801 0.780 rs2188962 chr5:131770805 C/T cg21138405 chr5:131827807 IRF1 -0.36 -6.26 -0.33 1.21e-9 Breast cancer;Mosquito bite size; CRC cis rs72781680 0.611 rs78861366 chr2:24354428 A/G cg20701182 chr2:24300061 SF3B14 0.65 7.79 0.39 9.06e-14 Lymphocyte counts; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg00004055 chr16:66586745 CKLF 0.5 7.21 0.37 3.79e-12 Response to antipsychotic treatment; CRC cis rs1552244 1.000 rs9811771 chr3:10133949 A/G cg16606324 chr3:10149918 C3orf24 0.69 9.7 0.47 1.02e-19 Alzheimer's disease; CRC cis rs7208859 0.673 rs73263755 chr17:29198972 A/G cg14008862 chr17:28927542 LRRC37B2 0.55 5.74 0.3 2.12e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs13191362 1.000 rs67046187 chr6:163068532 C/A cg06582575 chr6:163149167 PACRG;PARK2 0.93 11.9 0.55 2.04e-27 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs2204008 0.837 rs12366727 chr12:38365748 A/C cg26384229 chr12:38710491 ALG10B 0.69 9.25 0.45 2.98e-18 Bladder cancer; CRC cis rs9435341 0.965 rs2335104 chr1:107583641 A/T cg15468180 chr1:107600409 PRMT6 0.36 5.75 0.3 2.09e-8 Facial morphology (factor 21, depth of nasal alae); CRC cis rs9733 0.596 rs72702580 chr1:150691285 A/T cg15448220 chr1:150897856 SETDB1 0.45 6.41 0.33 5.09e-10 Tonsillectomy; CRC cis rs354225 0.626 rs6740893 chr2:54834380 G/A cg26097391 chr2:54893211 SPTBN1 0.4 5.85 0.31 1.19e-8 Schizophrenia; CRC cis rs9916302 0.706 rs4795385 chr17:37733148 A/G cg15445000 chr17:37608096 MED1 -0.36 -6.14 -0.32 2.38e-9 Glomerular filtration rate (creatinine); CRC cis rs13191362 1.000 rs35126854 chr6:163012443 C/T cg21926612 chr6:163149169 PACRG;PARK2 0.74 10.83 0.51 1.37e-23 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC trans rs7613875 0.580 rs6808044 chr3:50136165 A/G cg21659725 chr3:3221576 CRBN -0.43 -6.24 -0.33 1.33e-9 Body mass index; CRC cis rs651907 0.514 rs34301719 chr3:101417993 C/T cg11279151 chr3:101281821 RG9MTD1 -0.58 -7.78 -0.39 9.72e-14 Colorectal cancer; CRC cis rs561341 0.740 rs11080174 chr17:30208521 C/A cg00745463 chr17:30367425 LRRC37B 0.59 7.61 0.39 2.84e-13 Hip circumference adjusted for BMI; CRC cis rs6667605 0.527 rs4422947 chr1:2539590 C/T cg20673091 chr1:2541236 MMEL1 0.36 5.8 0.3 1.52e-8 Inflammatory bowel disease;Ulcerative colitis; CRC cis rs9786986 0.665 rs1874129 chr1:235700023 T/G cg08848088 chr1:235714526 GNG4 0.52 6.01 0.31 4.88e-9 Body mass index; CRC cis rs7255436 0.928 rs7250870 chr19:8453682 C/T cg10174797 chr19:8464628 RAB11B 0.44 7.68 0.39 1.81e-13 HDL cholesterol; CRC cis rs10791323 0.569 rs10750552 chr11:133740141 A/C cg15485101 chr11:133734466 NA -0.43 -8.13 -0.41 8.92e-15 Childhood ear infection; CRC cis rs1862618 0.853 rs832565 chr5:56150803 T/G cg20203395 chr5:56204925 C5orf35 -0.72 -8.55 -0.43 4.67e-16 Initial pursuit acceleration; CRC cis rs597539 0.690 rs608810 chr11:68624118 G/C cg04772025 chr11:68637568 NA 0.53 8.05 0.41 1.53e-14 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs6547741 1.000 rs6756238 chr2:27841305 G/A cg27432699 chr2:27873401 GPN1 0.77 13.64 0.6 6.76e-34 Oral cavity cancer; CRC cis rs853679 0.550 rs1150692 chr6:28173957 A/G cg12273811 chr6:28175739 NA 0.75 10.72 0.51 3.32e-23 Depression; CRC cis rs4862750 0.957 rs1030381 chr4:187903568 G/C cg10295955 chr4:187884368 NA -1.04 -24.66 -0.81 9.1e-77 Lobe attachment (rater-scored or self-reported); CRC trans rs7618501 0.699 rs2777888 chr3:49898000 A/G cg21665057 chr3:196295764 WDR53;FBXO45 0.67 10.57 0.5 1.14e-22 Intelligence (multi-trait analysis); CRC cis rs4665809 1.000 rs1030730 chr2:26284143 T/C cg25036284 chr2:26402008 FAM59B -0.47 -5.86 -0.31 1.14e-8 Gut microbiome composition (summer); CRC cis rs2811415 0.561 rs9839328 chr3:127763216 T/C cg13719885 chr3:127795394 NA -0.36 -5.62 -0.3 4.1e-8 Lung function (FEV1/FVC); CRC cis rs10540 1.000 rs35811812 chr11:498442 G/A cg15790184 chr11:494944 RNH1 0.62 6.91 0.36 2.5e-11 Body mass index; CRC cis rs2932538 0.922 rs12758377 chr1:113137221 C/A cg22162597 chr1:113214053 CAPZA1 0.73 10.49 0.5 2.15e-22 Systolic blood pressure;Diastolic blood pressure;Hypertension;Blood pressure; CRC cis rs6460942 0.908 rs3887296 chr7:12257966 A/G cg06484146 chr7:12443880 VWDE -0.56 -5.8 -0.3 1.56e-8 Coronary artery disease; CRC cis rs3820928 0.967 rs4675114 chr2:227768362 C/T cg11843606 chr2:227700838 RHBDD1 -0.41 -5.88 -0.31 1.02e-8 Pulmonary function; CRC cis rs6456156 0.774 rs2022001 chr6:167529509 C/T cg05540913 chr6:167530185 CCR6 -0.41 -7.43 -0.38 9.65e-13 Primary biliary cholangitis; CRC cis rs1215050 0.791 rs6532702 chr4:98766641 C/T cg05340658 chr4:99064831 C4orf37 0.46 6.58 0.34 1.84e-10 Waist-to-hip ratio adjusted for body mass index; CRC cis rs1862618 0.853 rs33326 chr5:56142601 G/A cg22800045 chr5:56110881 MAP3K1 0.58 6.39 0.33 5.62e-10 Initial pursuit acceleration; CRC cis rs6087990 0.735 rs2424921 chr20:31385814 C/T cg13636640 chr20:31349939 DNMT3B 0.79 13.97 0.61 3.82e-35 Ulcerative colitis; CRC cis rs12983728 0.831 rs35081008 chr19:58662235 C/T cg06882758 chr19:58662330 ZNF329 0.77 8.08 0.41 1.24e-14 Cholesterol, total; CRC cis rs9388451 0.839 rs9401845 chr6:126104118 A/G cg10911889 chr6:126070802 HEY2 0.39 5.92 0.31 7.99e-9 Brugada syndrome; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg21463023 chr3:42623862 SEC22C 0.43 6.1 0.32 3.06e-9 Intelligence (multi-trait analysis); CRC cis rs2204008 0.571 rs7970136 chr12:38531951 G/C cg26384229 chr12:38710491 ALG10B -0.52 -7.56 -0.38 4.18e-13 Bladder cancer; CRC cis rs2404602 0.569 rs2469249 chr15:76772062 C/T cg23625390 chr15:77176239 SCAPER -0.75 -10.49 -0.5 2.1e-22 Blood metabolite levels; CRC cis rs1218582 0.772 rs10908448 chr1:154882544 A/G cg24250549 chr1:154909240 PMVK -0.65 -11.35 -0.53 2.06e-25 Prostate cancer; CRC cis rs17376456 0.569 rs7702348 chr5:93065683 A/G cg09848695 chr5:92956644 FAM172A;MIR2277 -0.53 -6.4 -0.33 5.34e-10 Diabetic retinopathy; CRC cis rs9549328 0.731 rs2873371 chr13:113616242 C/T cg17524180 chr13:113633600 MCF2L -0.61 -11.14 -0.52 1.15e-24 Systolic blood pressure; CRC cis rs7949030 0.626 rs61296092 chr11:62320838 T/C cg11742103 chr11:62369870 EML3;MTA2 0.63 12.1 0.55 3.9e-28 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg25538649 chr17:74734108 MIR636;SFRS2;MFSD11 0.44 6.03 0.32 4.36e-9 Anxiety disorder; CRC cis rs2708977 1.000 rs1011040 chr2:97212755 A/G cg01950434 chr2:97203154 ARID5A -0.45 -6.5 -0.34 2.94e-10 Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes; CRC cis rs62458065 1.000 rs979355 chr7:32463933 A/G cg20159608 chr7:32802032 NA 0.51 6.6 0.34 1.61e-10 Metabolite levels (HVA/MHPG ratio); CRC cis rs2404602 0.692 rs12902452 chr15:76921465 T/C cg22467129 chr15:76604101 ETFA -0.38 -6.32 -0.33 8.49e-10 Blood metabolite levels; CRC cis rs868036 1.000 rs1026733 chr15:68095122 G/A cg05925327 chr15:68127851 NA -0.31 -6.01 -0.31 4.84e-9 Restless legs syndrome; CRC cis rs3749237 0.615 rs55957735 chr3:49438158 G/A cg03060546 chr3:49711283 APEH 0.6 10.25 0.49 1.36e-21 Resting heart rate; CRC cis rs9649213 0.574 rs62478236 chr7:98030377 G/A cg24562669 chr7:97807699 LMTK2 0.43 7.11 0.36 7.49e-12 Prostate cancer (SNP x SNP interaction); CRC cis rs4566357 0.615 rs4350744 chr2:227918146 A/T cg11843606 chr2:227700838 RHBDD1 -0.44 -6.81 -0.35 4.52e-11 Coronary artery disease; CRC cis rs2811415 0.531 rs9850146 chr3:127744122 G/T cg13719885 chr3:127795394 NA -0.37 -5.69 -0.3 2.74e-8 Lung function (FEV1/FVC); CRC cis rs1153858 1.000 rs12593230 chr15:45646968 A/T cg14582100 chr15:45693742 SPATA5L1 0.29 6.02 0.32 4.55e-9 Homoarginine levels; CRC cis rs9549367 0.713 rs3024745 chr13:113821598 A/G cg18105134 chr13:113819100 PROZ -0.86 -12.88 -0.58 5.09e-31 Platelet distribution width; CRC cis rs11203032 0.831 rs12570154 chr10:90951027 T/C cg16672925 chr10:90967113 CH25H 0.45 5.74 0.3 2.17e-8 Heart failure; CRC cis rs10504229 0.593 rs77607045 chr8:58010464 T/C cg24829409 chr8:58192753 C8orf71 -0.54 -6.59 -0.34 1.75e-10 Developmental language disorder (linguistic errors); CRC cis rs6582630 0.555 rs7978749 chr12:38527141 G/T cg13010199 chr12:38710504 ALG10B 0.49 6.53 0.34 2.54e-10 Drug-induced liver injury (flucloxacillin); CRC cis rs7412746 0.611 rs10888394 chr1:150749913 C/T cg17724175 chr1:150552817 MCL1 0.48 7.08 0.36 8.66e-12 Melanoma; CRC trans rs13315871 0.654 rs11711261 chr3:58343696 C/A cg25250853 chr2:85822726 RNF181 0.53 6.35 0.33 7.16e-10 Cholesterol, total; CRC cis rs60871478 0.636 rs4721600 chr7:871728 C/T cg13844804 chr7:814759 HEATR2 -0.56 -5.86 -0.31 1.12e-8 Cerebrospinal P-tau181p levels; CRC trans rs10242455 0.867 rs13362853 chr7:99223147 T/C cg09045935 chr12:6379348 NA 0.61 6.72 0.35 7.84e-11 Blood metabolite levels; CRC cis rs644799 0.965 rs3016295 chr11:95554311 A/G cg25478527 chr11:95522999 CEP57;FAM76B 0.51 7.74 0.39 1.26e-13 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs10504229 0.593 rs74760806 chr8:58024785 C/T cg02290350 chr8:58132656 NA -0.46 -5.84 -0.31 1.24e-8 Developmental language disorder (linguistic errors); CRC trans rs3942852 0.806 rs1503188 chr11:48117478 C/T cg03929089 chr4:120376271 NA -0.55 -6.99 -0.36 1.52e-11 Acute lymphoblastic leukemia (childhood); CRC cis rs10782582 0.593 rs11163904 chr1:76121208 A/G cg03433033 chr1:76189801 ACADM 0.42 6.13 0.32 2.57e-9 Daytime sleep phenotypes; CRC cis rs2732480 0.500 rs12829841 chr12:48628739 A/G cg21466736 chr12:48725269 NA -0.56 -8.32 -0.42 2.36e-15 Hemoglobin concentration;Red blood cell count;Hematocrit; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg27537591 chr10:116697898 TRUB1 0.47 6.82 0.35 4.37e-11 Intelligence (multi-trait analysis); CRC cis rs6860806 0.507 rs2631371 chr5:131703691 G/A cg18301423 chr5:131593218 PDLIM4 -0.39 -6.51 -0.34 2.75e-10 Breast cancer; CRC cis rs2932538 0.961 rs6690292 chr1:113188419 C/T cg22162597 chr1:113214053 CAPZA1 -0.58 -8.45 -0.42 9.66e-16 Systolic blood pressure;Diastolic blood pressure;Hypertension;Blood pressure; CRC cis rs910316 0.737 rs2098251 chr14:75492696 G/A cg11812906 chr14:75593930 NEK9 0.59 9.27 0.46 2.54e-18 Height; CRC cis rs7584330 0.541 rs10202181 chr2:238352099 A/G cg14458575 chr2:238380390 NA 0.67 11.52 0.54 5.1e-26 Prostate cancer; CRC cis rs561341 1.000 rs72823785 chr17:30273784 C/T cg00745463 chr17:30367425 LRRC37B -0.9 -9.89 -0.48 2.27e-20 Hip circumference adjusted for BMI; CRC cis rs4820539 0.932 rs3788349 chr22:23467950 A/G cg14186256 chr22:23484241 RTDR1 0.92 18.25 0.71 6.78e-52 Bone mineral density; CRC cis rs9747201 1.000 rs9747201 chr17:80177852 A/C cg09264619 chr17:80180166 NA -0.48 -6.88 -0.35 3.07e-11 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs736408 0.608 rs2239547 chr3:52855229 T/C cg10802521 chr3:52805072 NEK4 -0.46 -6.22 -0.32 1.5e-9 Bipolar disorder; CRC cis rs11190604 1.000 rs7078799 chr10:102301447 G/A cg16342193 chr10:102329863 NA -0.36 -5.99 -0.31 5.62e-9 Palmitoleic acid (16:1n-7) levels; CRC cis rs9325144 0.560 rs7980635 chr12:38668355 G/T cg26384229 chr12:38710491 ALG10B -0.55 -8.21 -0.41 5.15e-15 Morning vs. evening chronotype; CRC cis rs9309473 0.583 rs6546822 chr2:73575098 G/A cg20560298 chr2:73613845 ALMS1 -0.5 -6.84 -0.35 3.97e-11 Metabolite levels; CRC cis rs853679 0.517 rs4713145 chr6:28106827 T/C cg06470822 chr6:28175283 NA 1.0 13.33 0.59 1.06e-32 Depression; CRC cis rs4819052 0.851 rs4819043 chr21:46660078 G/A cg02159808 chr21:46707872 POFUT2;LOC642852 0.49 6.44 0.33 4.36e-10 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs35146811 0.735 rs6948729 chr7:99787372 A/G cg00553149 chr7:99775558 STAG3;GPC2 0.24 5.9 0.31 8.81e-9 Coronary artery disease; CRC cis rs7945705 0.714 rs2653570 chr11:8987823 A/G cg14711859 chr11:8959438 ASCL3 0.38 6.43 0.33 4.45e-10 Hemoglobin concentration; CRC cis rs2404602 0.716 rs1874944 chr15:76863928 A/G cg03037974 chr15:76606532 NA 0.66 11.44 0.53 9.38e-26 Blood metabolite levels; CRC cis rs7703744 0.681 rs73239280 chr5:118695579 G/A cg19893178 chr5:118692011 TNFAIP8 0.45 6.05 0.32 3.86e-9 Lobe attachment (rater-scored or self-reported); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg26227975 chr3:9773404 BRPF1 0.41 6.11 0.32 2.81e-9 Intelligence (multi-trait analysis); CRC cis rs758324 0.617 rs12719447 chr5:131118100 C/A cg06307176 chr5:131281290 NA 0.43 6.52 0.34 2.7e-10 Alzheimer's disease in APOE e4- carriers; CRC cis rs9921222 0.500 rs8046256 chr16:393948 C/T cg08923669 chr16:420230 MRPL28 -0.79 -10.23 -0.49 1.59e-21 Bone mineral density (spine);Bone mineral density; CRC cis rs2243480 0.803 rs34004500 chr7:65312178 A/T cg12463550 chr7:65579703 CRCP 0.66 6.14 0.32 2.36e-9 Diabetic kidney disease; CRC cis rs736408 0.507 rs6445531 chr3:52717282 T/C cg05573699 chr3:52720067 GNL3;PBRM1 -0.49 -7.24 -0.37 3.14e-12 Bipolar disorder; CRC cis rs72772090 0.539 rs3333 chr5:96115111 G/A cg17330273 chr5:96107758 CAST;ERAP1 -0.69 -6.4 -0.33 5.48e-10 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs4819052 0.851 rs10470246 chr21:46659017 C/G cg19498844 chr21:46707878 POFUT2;LOC642852 0.75 10.82 0.51 1.49e-23 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg11003009 chr5:74632112 HMGCR 0.39 6.29 0.33 1.04e-9 Response to antipsychotic treatment; CRC cis rs2243480 1.000 rs6966322 chr7:65646754 A/G cg25985355 chr7:65971099 NA 0.52 6.01 0.31 4.92e-9 Diabetic kidney disease; CRC cis rs10489202 0.632 rs202259 chr1:167962072 G/A cg24449463 chr1:168025552 DCAF6 -0.61 -9.2 -0.45 4.17e-18 Schizophrenia; CRC cis rs10504229 1.000 rs114486414 chr8:58185103 G/A cg01721255 chr8:58191610 C8orf71 0.49 6.17 0.32 2e-9 Developmental language disorder (linguistic errors); CRC trans rs10982213 0.830 rs2274163 chr9:117188714 C/T cg18358588 chr6:26660131 ZNF322A 0.42 6.55 0.34 2.23e-10 Interleukin-6 levels; CRC trans rs800082 1.000 rs2575194 chr3:144284871 C/T cg24215973 chr2:240111563 HDAC4 0.49 6.74 0.35 7.03e-11 Smoking behavior; CRC cis rs11112613 0.713 rs12296355 chr12:105953321 C/A cg03607813 chr12:105948248 NA 0.77 10.76 0.51 2.39e-23 Corrected insulin response;Corrected insulin response adjusted for insulin sensitivity index; CRC cis rs8078723 1.000 rs2227336 chr17:38174855 T/G cg17467752 chr17:38218738 THRA 0.74 12.1 0.55 3.95e-28 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); CRC cis rs78456975 1.000 rs11903168 chr2:1560497 C/G cg12573674 chr2:1569213 NA -0.77 -8.05 -0.41 1.51e-14 Placebo response in major depressive disorder (% change in symptom score); CRC cis rs7769051 1.000 rs6910639 chr6:133120553 A/G cg22852734 chr6:133119734 C6orf192 1.06 12.88 0.58 5.3e-31 Type 2 diabetes nephropathy; CRC cis rs1005277 0.522 rs289645 chr10:37943642 T/C cg25517755 chr10:38738941 LOC399744 -0.41 -5.95 -0.31 6.82e-9 Extrinsic epigenetic age acceleration; CRC cis rs2404602 0.647 rs11072625 chr15:77084984 A/G cg23625390 chr15:77176239 SCAPER 0.84 12.49 0.57 1.42e-29 Blood metabolite levels; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg12847584 chr20:42839925 C20orf111 0.45 6.42 0.33 4.74e-10 Response to antipsychotic treatment; CRC cis rs3785574 0.886 rs62077504 chr17:61837734 A/G cg06873352 chr17:61820015 STRADA 0.5 8.07 0.41 1.32e-14 Height; CRC cis rs3820928 1.000 rs7579961 chr2:227776976 T/A cg11843606 chr2:227700838 RHBDD1 -0.41 -5.98 -0.31 5.91e-9 Pulmonary function; CRC cis rs6429082 0.749 rs3819974 chr1:235601958 G/T cg26050004 chr1:235667680 B3GALNT2 -0.53 -7.16 -0.37 5.38e-12 Adiposity; CRC cis rs939658 1.000 rs8027411 chr15:79461029 G/T cg17916960 chr15:79447300 NA 0.47 7.66 0.39 2.16e-13 Refractive error; CRC cis rs12580194 0.593 rs61956275 chr12:55786423 G/A cg23425280 chr12:56401806 NA 0.47 5.71 0.3 2.53e-8 Cancer; CRC cis rs17376456 1.000 rs67150649 chr5:93292377 A/G cg09848695 chr5:92956644 FAM172A;MIR2277 0.68 6.0 0.31 5.1e-9 Diabetic retinopathy; CRC cis rs863345 0.534 rs10797009 chr1:158446048 T/A cg12129480 chr1:158549410 OR10X1 -0.29 -6.17 -0.32 1.99e-9 Pneumococcal bacteremia; CRC cis rs1552244 1.000 rs67134728 chr3:10151431 G/C cg18598329 chr3:10140678 FANCD2;C3orf24 -0.89 -11.92 -0.55 1.84e-27 Alzheimer's disease; CRC cis rs34172651 0.517 rs11862923 chr16:24767303 G/T cg06028605 chr16:24865363 SLC5A11 0.6 10.05 0.48 6.56e-21 Intelligence (multi-trait analysis); CRC cis rs7666738 0.791 rs7658177 chr4:99035192 T/C cg17366294 chr4:99064904 C4orf37 0.44 7.47 0.38 7.18e-13 Colonoscopy-negative controls vs population controls; CRC cis rs9372498 0.505 rs9489493 chr6:118992323 T/C cg22561889 chr6:118971681 C6orf204 0.44 6.05 0.32 3.97e-9 Diastolic blood pressure; CRC cis rs4363385 0.747 rs1577965 chr1:152968294 T/C cg25856811 chr1:152973957 SPRR3 -0.25 -6.82 -0.35 4.51e-11 Inflammatory skin disease; CRC cis rs28386778 0.897 rs2665823 chr17:61885917 G/A cg25654072 chr17:61904446 PSMC5;FTSJ3 0.72 11.28 0.53 3.5e-25 Prudent dietary pattern; CRC cis rs9462846 0.853 rs34455103 chr6:42875128 C/G cg21280719 chr6:42927975 GNMT -0.33 -6.23 -0.32 1.45e-9 Blood protein levels; CRC cis rs2245008 0.950 rs824400 chr16:83989936 C/G cg07978099 chr16:83986941 OSGIN1 -0.55 -6.66 -0.34 1.14e-10 Pursuit maintenance gain; CRC cis rs6903823 0.527 rs4713158 chr6:28277771 C/A cg03623178 chr6:28175578 NA 0.48 6.68 0.35 1.02e-10 Pulmonary function; CRC cis rs752010 0.875 rs11210502 chr1:42093712 A/C cg06885757 chr1:42089581 HIVEP3 0.55 9.45 0.46 6.51e-19 Lupus nephritis in systemic lupus erythematosus; CRC cis rs58688157 0.705 rs12421646 chr11:578844 C/G cg03909863 chr11:638404 DRD4 -0.49 -6.43 -0.33 4.47e-10 Systemic lupus erythematosus; CRC cis rs4713118 0.869 rs9295743 chr6:27715102 G/C cg19041857 chr6:27730383 NA -0.41 -5.99 -0.31 5.45e-9 Parkinson's disease; CRC cis rs947211 0.846 rs708726 chr1:205762139 G/T cg07157834 chr1:205819609 PM20D1 -0.43 -6.15 -0.32 2.2e-9 Parkinson's disease; CRC cis rs6502050 0.777 rs4625783 chr17:80086395 T/C cg19223190 chr17:80058835 NA -0.39 -6.25 -0.33 1.27e-9 Life satisfaction; CRC cis rs1568889 1.000 rs2354427 chr11:28049623 T/A cg06544937 chr11:28130018 METT5D1;KIF18A 0.78 11.27 0.53 3.9e-25 Bipolar disorder; CRC cis rs7726839 0.540 rs61731455 chr5:665295 A/G cg09021430 chr5:549028 NA -0.72 -7.85 -0.4 5.9e-14 Obesity-related traits; CRC trans rs9329221 0.521 rs4841294 chr8:10105068 G/T cg16141378 chr3:129829833 LOC729375 0.44 6.61 0.34 1.56e-10 Neuroticism; CRC cis rs6942756 0.774 rs66479871 chr7:129009687 T/C cg02491457 chr7:128862824 NA -0.61 -8.54 -0.43 5.23e-16 White matter hyperintensity burden; CRC cis rs6693567 0.565 rs7513182 chr1:150442612 A/G cg15654264 chr1:150340011 RPRD2 -0.41 -6.04 -0.32 4.18e-9 Migraine; CRC cis rs2985684 1.000 rs2985697 chr14:50092902 A/G cg10008539 chr14:50087325 RPL36AL;MGAT2 -0.42 -6.04 -0.32 4.22e-9 Carotid intima media thickness; CRC trans rs11039798 0.588 rs113800184 chr11:48756855 G/A cg03929089 chr4:120376271 NA 0.67 6.98 0.36 1.65e-11 Axial length; CRC cis rs1448094 0.512 rs11503595 chr12:86244075 T/A cg19622623 chr12:86230825 RASSF9 -0.41 -6.7 -0.35 9.04e-11 Major depressive disorder; CRC cis rs6938 0.534 rs11072512 chr15:75204026 C/T cg09165964 chr15:75287851 SCAMP5 0.61 9.67 0.47 1.25e-19 Breast cancer; CRC cis rs6712932 1.000 rs6734358 chr2:105843732 A/C cg27422857 chr2:105853526 NA -0.32 -6.12 -0.32 2.71e-9 Type 2 diabetes; CRC cis rs4819052 0.851 rs10470245 chr21:46658912 A/G cg02159808 chr21:46707872 POFUT2;LOC642852 0.49 6.42 0.33 4.83e-10 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs6598955 0.950 rs6700455 chr1:26545864 T/C cg04990556 chr1:26633338 UBXN11 0.81 12.23 0.56 1.27e-28 Obesity-related traits; CRC cis rs1008375 0.966 rs2098152 chr4:17684392 G/T cg04450456 chr4:17643702 FAM184B 0.38 6.16 0.32 2.16e-9 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs11190604 1.000 rs6584383 chr10:102303065 C/G cg07080220 chr10:102295463 HIF1AN 0.49 6.33 0.33 7.83e-10 Palmitoleic acid (16:1n-7) levels; CRC cis rs1451375 0.698 rs56766899 chr7:50648938 T/C cg18232548 chr7:50535776 DDC 0.44 6.25 0.33 1.24e-9 Malaria; CRC cis rs4927850 1.000 rs7627706 chr3:195753353 A/C cg01181863 chr3:195395398 SDHAP2 -0.57 -8.0 -0.4 2.17e-14 Pancreatic cancer; CRC trans rs6600671 1.000 rs2185281 chr1:121179991 A/G cg00646200 chr1:148855367 NA 0.35 6.38 0.33 6.17e-10 Hip geometry; CRC cis rs35146811 0.695 rs1727132 chr7:99812297 T/C cg13334819 chr7:99746414 C7orf59 0.51 6.71 0.35 8.67e-11 Coronary artery disease; CRC cis rs1568889 1.000 rs7937778 chr11:28104605 C/T cg06544937 chr11:28130018 METT5D1;KIF18A 0.78 11.27 0.53 3.9e-25 Bipolar disorder; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg12703194 chr16:3086867 CCDC64B 0.43 7.43 0.38 9.54e-13 Liver disease severity in Alagille syndrome; CRC cis rs2249694 0.959 rs2987799 chr10:135380499 T/G cg20169779 chr10:135381914 SYCE1 0.65 11.01 0.52 3.24e-24 Obesity-related traits; CRC cis rs910316 0.789 rs175457 chr14:75584507 C/T cg08847533 chr14:75593920 NEK9 -0.84 -14.92 -0.64 7.98e-39 Height; CRC cis rs2033908 0.620 rs1992335 chr11:12851717 A/C cg25843174 chr11:12811716 TEAD1 -0.4 -7.25 -0.37 3.08e-12 Sitting height ratio; CRC trans rs2797160 1.000 rs2747717 chr6:126008435 A/G cg05039488 chr6:79577232 IRAK1BP1 0.49 7.29 0.37 2.25e-12 Endometrial cancer; CRC cis rs9372498 0.536 rs62422189 chr6:118907053 C/T cg10217327 chr6:118973057 C6orf204 0.56 6.16 0.32 2.13e-9 Diastolic blood pressure; CRC cis rs4240897 0.935 rs4846082 chr1:12042443 C/T cg13216073 chr1:12042593 MFN2 0.61 10.31 0.49 8.56e-22 Tuberculosis; CRC trans rs7647973 0.587 rs10452032 chr3:49680973 G/A cg21665057 chr3:196295764 WDR53;FBXO45 -0.68 -7.46 -0.38 7.88e-13 Menarche (age at onset); CRC cis rs7119 1.000 rs7119 chr15:77777632 C/T cg10437265 chr15:77819839 NA 0.42 7.33 0.37 1.74e-12 Type 2 diabetes; CRC cis rs6502050 0.835 rs3935816 chr17:80137173 C/T cg02741985 chr17:80059408 CCDC57 0.42 6.93 0.36 2.22e-11 Life satisfaction; CRC cis rs13394619 0.775 rs10165819 chr2:11722102 A/T cg07314298 chr2:11723111 GREB1 -0.48 -8.19 -0.41 5.87e-15 Endometriosis; CRC cis rs9649213 0.593 rs2240349 chr7:97984663 C/T cg24562669 chr7:97807699 LMTK2 0.44 7.27 0.37 2.71e-12 Prostate cancer (SNP x SNP interaction); CRC cis rs8077889 0.957 rs17742929 chr17:41891437 C/T cg26893861 chr17:41843967 DUSP3 0.84 10.67 0.51 5.09e-23 Triglycerides; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg19027507 chr1:27320128 TRNP1 0.47 6.83 0.35 4.17e-11 Intelligence (multi-trait analysis); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg17265729 chr1:89990859 LRRC8B 0.41 5.97 0.31 6.02e-9 Intelligence (multi-trait analysis); CRC cis rs3806843 0.612 rs246075 chr5:140300557 T/C cg19875535 chr5:140030758 IK 0.42 6.46 0.34 3.66e-10 Depressive symptoms (multi-trait analysis); CRC cis rs9733 0.519 rs6700022 chr1:150670484 G/T cg17724175 chr1:150552817 MCL1 -0.58 -9.74 -0.47 7.53e-20 Tonsillectomy; CRC cis rs9747201 0.862 rs57596657 chr17:80147978 C/T cg14673194 chr17:80132900 CCDC57 -0.5 -6.59 -0.34 1.7e-10 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs2976388 0.578 rs13254358 chr8:143823876 G/A cg24046110 chr8:143859143 LYNX1 -0.43 -6.55 -0.34 2.24e-10 Urinary tract infection frequency; CRC cis rs1218582 0.628 rs12130132 chr1:154880386 C/T cg03351412 chr1:154909251 PMVK 0.52 7.39 0.38 1.2e-12 Prostate cancer; CRC cis rs3858526 0.883 rs1453429 chr11:5933478 C/T cg05234568 chr11:5960015 NA -0.53 -7.3 -0.37 2.17e-12 DNA methylation (variation); CRC trans rs7937682 0.924 rs489783 chr11:111520522 A/G cg18187862 chr3:45730750 SACM1L 0.48 6.88 0.35 3.04e-11 Primary sclerosing cholangitis; CRC cis rs2032447 0.736 rs115810 chr6:25975883 G/C cg27635394 chr6:26043820 HIST1H2BB 0.46 6.67 0.35 1.09e-10 Intelligence (multi-trait analysis); CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg26716323 chr7:22862328 TOMM7 0.5 6.7 0.35 9.18e-11 Thyroid stimulating hormone; CRC trans rs8002861 0.846 rs12428112 chr13:44475821 C/A cg17145862 chr1:211918768 LPGAT1 -0.68 -12.34 -0.56 5.36e-29 Leprosy; CRC cis rs1552244 0.554 rs17050705 chr3:10046398 G/C cg18598329 chr3:10140678 FANCD2;C3orf24 -0.53 -7.53 -0.38 4.84e-13 Alzheimer's disease; CRC cis rs6543140 0.964 rs10196334 chr2:103090041 T/C cg09003973 chr2:102972529 NA 0.42 5.93 0.31 7.87e-9 Blood protein levels; CRC cis rs6912958 0.781 rs985764 chr6:88215206 G/A cg08069147 chr6:88032118 GJB7;C6orf162 -0.55 -8.19 -0.41 5.68e-15 Monocyte percentage of white cells; CRC cis rs17270561 0.779 rs12210620 chr6:25884785 T/C cg17691542 chr6:26056736 HIST1H1C 0.79 10.17 0.49 2.62e-21 Iron status biomarkers; CRC cis rs11252926 0.563 rs10795103 chr10:451849 C/A cg18196295 chr10:418757 DIP2C 0.52 8.14 0.41 8.08e-15 Psychosis in Alzheimer's disease; CRC cis rs11583043 1.000 rs17123612 chr1:101476814 C/T cg16556008 chr1:101360663 SLC30A7;EXTL2 0.45 5.68 0.3 3.01e-8 Ulcerative colitis;Inflammatory bowel disease; CRC cis rs4713118 0.869 rs6930992 chr6:27712120 A/C cg02683197 chr6:28174875 NA 0.63 8.62 0.43 2.81e-16 Parkinson's disease; CRC cis rs10504229 0.728 rs72650860 chr8:58153111 A/G cg05313129 chr8:58192883 C8orf71 -0.47 -6.18 -0.32 1.94e-9 Developmental language disorder (linguistic errors); CRC cis rs826838 0.967 rs1684413 chr12:39128704 G/A cg13010199 chr12:38710504 ALG10B -0.41 -5.84 -0.31 1.27e-8 Heart rate; CRC cis rs8180040 0.966 rs11130137 chr3:47578838 C/T cg02527881 chr3:46936655 PTH1R -0.38 -7.15 -0.37 5.67e-12 Colorectal cancer; CRC trans rs1728785 0.901 rs698711 chr16:68561955 C/T cg04657470 chr2:198365150 HSPE1;HSPD1 0.54 6.43 0.33 4.46e-10 Ulcerative colitis; CRC trans rs9858542 1.000 rs11130213 chr3:49712297 C/T cg21582582 chr3:182698605 DCUN1D1 -0.55 -6.56 -0.34 2.05e-10 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs745570 1.000 rs745570 chr17:77781725 A/G cg04986373 chr17:77768687 CBX8 0.45 6.81 0.35 4.61e-11 Breast cancer; CRC cis rs6502050 0.830 rs7219036 chr17:80161119 T/C cg22110888 chr17:80059540 CCDC57 0.38 6.08 0.32 3.31e-9 Life satisfaction; CRC cis rs72781680 0.716 rs2551326 chr2:23982378 T/C cg08917208 chr2:24149416 ATAD2B 0.56 6.43 0.33 4.58e-10 Lymphocyte counts; CRC cis rs9916302 0.904 rs10221223 chr17:37489100 T/G cg15445000 chr17:37608096 MED1 -0.42 -9.13 -0.45 7.21e-18 Glomerular filtration rate (creatinine); CRC cis rs4713118 0.587 rs9393899 chr6:28133528 G/C cg15845792 chr6:28175446 NA 1.04 13.89 0.61 7.67e-35 Parkinson's disease; CRC cis rs17270561 0.514 rs10946805 chr6:26077891 C/T cg17691542 chr6:26056736 HIST1H1C 1.02 12.48 0.57 1.56e-29 Iron status biomarkers; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg19318326 chr6:111580704 KIAA1919 0.44 6.22 0.32 1.5e-9 Response to antipsychotic treatment; CRC cis rs11098499 0.874 rs6826823 chr4:120112098 G/C cg24375607 chr4:120327624 NA 0.48 7.25 0.37 3.02e-12 Corneal astigmatism; CRC cis rs10751667 0.643 rs6597970 chr11:928669 C/A cg01483505 chr11:975446 AP2A2 0.43 6.87 0.35 3.3e-11 Alzheimer's disease (late onset); CRC cis rs172166 0.637 rs1071893 chr6:28167635 G/C cg25164649 chr6:28176230 NA 0.67 10.08 0.49 5.35e-21 Cardiac Troponin-T levels; CRC cis rs6952808 0.825 rs34296663 chr7:1935245 C/T cg20295408 chr7:1910781 MAD1L1 -0.42 -5.99 -0.31 5.43e-9 Bipolar disorder and schizophrenia; CRC cis rs4713118 0.513 rs183244 chr6:28031838 C/A cg25164649 chr6:28176230 NA 0.59 8.24 0.41 4.21e-15 Parkinson's disease; CRC cis rs2404602 0.647 rs12903331 chr15:77168268 C/G cg23625390 chr15:77176239 SCAPER -0.88 -14.1 -0.61 1.17e-35 Blood metabolite levels; CRC cis rs72781680 0.752 rs72796130 chr2:23919740 T/C cg08917208 chr2:24149416 ATAD2B 0.99 9.16 0.45 5.85e-18 Lymphocyte counts; CRC cis rs3204270 0.714 rs79243595 chr17:79681220 T/C cg09655341 chr17:79618100 PDE6G 0.52 6.06 0.32 3.75e-9 Dental caries; CRC cis rs6912958 0.684 rs4707382 chr6:88320641 T/C cg08069147 chr6:88032118 GJB7;C6orf162 -0.57 -8.61 -0.43 3.12e-16 Monocyte percentage of white cells; CRC cis rs10751667 0.925 rs7115336 chr11:988101 C/G ch.11.42038R chr11:967971 AP2A2 0.7 11.76 0.54 7.07e-27 Alzheimer's disease (late onset); CRC cis rs853679 0.550 rs1237875 chr6:28173010 A/G cg06470822 chr6:28175283 NA -1.0 -15.26 -0.64 3.87e-40 Depression; CRC cis rs12188164 0.543 rs2434694 chr5:462734 C/T cg26850624 chr5:429559 AHRR 0.52 8.87 0.44 4.87e-17 Cystic fibrosis severity; CRC cis rs7712401 0.791 rs10071135 chr5:122146978 C/G cg18764291 chr5:122110994 SNX2 0.36 5.79 0.3 1.62e-8 Mean platelet volume; CRC cis rs4713118 0.824 rs2179095 chr6:27750858 A/G cg15786705 chr6:28176104 NA -0.54 -7.05 -0.36 1.04e-11 Parkinson's disease; CRC cis rs8077889 1.000 rs2079005 chr17:41865627 T/G cg26893861 chr17:41843967 DUSP3 0.99 12.71 0.57 2.26e-30 Triglycerides; CRC cis rs6429082 0.510 rs3806393 chr1:235492546 T/G cg26050004 chr1:235667680 B3GALNT2 0.39 5.79 0.3 1.64e-8 Adiposity; CRC cis rs40363 0.680 rs72778116 chr16:3530752 A/G cg22508957 chr16:3507546 NAT15 0.77 7.63 0.39 2.56e-13 Tuberculosis; CRC cis rs1218582 0.772 rs2335408 chr1:154915977 G/A cg16680214 chr1:154839983 KCNN3 -0.44 -8.51 -0.42 6.33e-16 Prostate cancer; CRC cis rs7937682 1.000 rs7937682 chr11:111579939 C/G cg09085632 chr11:111637200 PPP2R1B -1.02 -19.28 -0.73 5.86e-56 Primary sclerosing cholangitis; CRC cis rs294883 0.712 rs9456392 chr6:159733077 C/T cg14500486 chr6:159655392 FNDC1 -0.36 -6.05 -0.32 3.83e-9 Coronary artery disease; CRC cis rs7074356 0.569 rs1832683 chr10:82032331 C/T cg27171509 chr10:82033454 MAT1A -0.48 -8.58 -0.43 3.84e-16 Borderline personality disorder; CRC trans rs4927850 0.958 rs1975582 chr3:195751439 G/T cg16724585 chr3:197361211 NA -0.48 -7.1 -0.36 7.62e-12 Pancreatic cancer; CRC cis rs11690935 0.959 rs6745143 chr2:172650382 G/A cg13550731 chr2:172543902 DYNC1I2 -1.08 -18.27 -0.71 5.57e-52 Schizophrenia; CRC trans rs12517041 1.000 rs7721619 chr5:23292676 C/T ch.8.1293020R chr8:59333349 UBXN2B -0.55 -6.17 -0.32 2.05e-9 Calcium levels; CRC cis rs8077889 0.917 rs6503479 chr17:41917003 A/G cg16892393 chr17:41919603 NA 0.47 7.08 0.36 8.59e-12 Triglycerides; CRC cis rs11190604 1.000 rs2495736 chr10:102338410 T/C cg16342193 chr10:102329863 NA -0.4 -6.41 -0.33 4.91e-10 Palmitoleic acid (16:1n-7) levels; CRC cis rs7666738 0.753 rs10033138 chr4:98981922 A/C cg17366294 chr4:99064904 C4orf37 0.43 7.33 0.37 1.76e-12 Colonoscopy-negative controls vs population controls; CRC trans rs703108 0.731 rs7898954 chr10:22323646 A/G cg13497285 chr20:8000588 TMX4 -0.51 -5.96 -0.31 6.48e-9 Monocyte percentage of white cells; CRC cis rs10463316 0.608 rs7700423 chr5:150769155 C/T cg03212797 chr5:150827313 SLC36A1 -0.49 -7.8 -0.4 8.25e-14 Metabolite levels (Pyroglutamine); CRC cis rs10197940 0.624 rs4461258 chr2:152429679 A/G cg19508488 chr2:152266495 RIF1 -0.55 -7.58 -0.39 3.6e-13 Lung cancer; CRC cis rs6951245 0.748 rs79658522 chr7:1095877 A/G cg03188948 chr7:1209495 NA 0.66 6.94 0.36 2.04e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs2811415 0.597 rs13063604 chr3:127804730 G/A cg13719885 chr3:127795394 NA -0.4 -5.92 -0.31 8.11e-9 Lung function (FEV1/FVC); CRC cis rs853679 0.517 rs9468286 chr6:28079428 C/T cg03623178 chr6:28175578 NA 0.95 12.17 0.56 2.13e-28 Depression; CRC cis rs2811415 0.597 rs9854763 chr3:127797890 A/G cg13719885 chr3:127795394 NA -0.4 -6.02 -0.32 4.57e-9 Lung function (FEV1/FVC); CRC cis rs67311347 1.000 rs9882171 chr3:40518821 G/A cg09455208 chr3:40491958 NA 0.45 9.15 0.45 6.15e-18 Renal cell carcinoma; CRC cis rs2115630 0.645 rs1107179 chr15:85198362 A/C cg12501888 chr15:85177176 SCAND2 0.45 7.53 0.38 5.06e-13 P wave terminal force; CRC cis rs1153858 1.000 rs61365925 chr15:45650311 T/C cg10760299 chr15:45669010 GATM 0.5 7.95 0.4 2.96e-14 Homoarginine levels; CRC cis rs11148252 0.846 rs7323666 chr13:53006058 T/C cg00495681 chr13:53174319 NA 0.58 8.74 0.43 1.19e-16 Lewy body disease; CRC cis rs910316 1.000 rs3742773 chr14:75579643 A/G cg08847533 chr14:75593920 NEK9 0.92 17.32 0.69 3.13e-48 Height; CRC cis rs5753618 0.583 rs7287267 chr22:31748415 C/T cg22777020 chr22:31556080 RNF185 0.46 5.76 0.3 1.9e-8 Colorectal cancer; CRC cis rs875971 0.522 rs1617484 chr7:65463095 G/A cg11764359 chr7:65958608 NA 0.47 7.11 0.36 7.28e-12 Aortic root size; CRC trans rs78049276 0.512 rs7659823 chr4:148398877 C/G cg13149281 chr14:23389818 RBM23;PRMT5 -0.55 -7.38 -0.38 1.31e-12 Pulse pressure; CRC cis rs2933343 0.630 rs75824035 chr3:128652985 T/C cg25356066 chr3:128598488 ACAD9 0.39 5.64 0.3 3.6e-8 IgG glycosylation; CRC cis rs3789045 0.560 rs1008833 chr1:204426295 A/G cg17419461 chr1:204415978 PIK3C2B -0.82 -10.97 -0.52 4.58e-24 Educational attainment (college completion); CRC cis rs2455601 0.786 rs3763914 chr11:8940703 G/T cg09997546 chr11:8931473 C11orf17;ST5 -0.51 -6.8 -0.35 4.91e-11 Schizophrenia; CRC cis rs1218582 0.804 rs4845678 chr1:154853295 A/G cg09359103 chr1:154839909 KCNN3 -0.72 -13.08 -0.58 9.12e-32 Prostate cancer; CRC cis rs9457247 1.000 rs2013815 chr6:167373812 T/A cg23791538 chr6:167370224 RNASET2 0.39 6.07 0.32 3.46e-9 Crohn's disease; CRC cis rs13256369 1.000 rs4841017 chr8:8577093 A/G cg06671706 chr8:8559999 CLDN23 0.58 9.15 0.45 6.33e-18 Obesity-related traits; CRC cis rs6681460 0.674 rs7543607 chr1:67012592 G/T cg02459107 chr1:67143332 SGIP1 0.36 5.87 0.31 1.09e-8 Presence of antiphospholipid antibodies; CRC cis rs2836974 0.897 rs68090597 chr21:40535633 A/G cg11890956 chr21:40555474 PSMG1 1.1 21.46 0.76 1.66e-64 Cognitive function; CRC cis rs910316 0.737 rs175084 chr14:75519175 C/T cg03030879 chr14:75389066 RPS6KL1 0.41 6.22 0.32 1.51e-9 Height; CRC cis rs12692738 0.526 rs355871 chr2:165632068 A/G cg03182029 chr2:165697222 COBLL1 0.5 5.86 0.31 1.11e-8 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);Waist-to-hip ratio adjusted for BMI in non-smokers;Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction);Waist-to-hip ratio adjusted for body mass index; CRC cis rs7914558 1.000 rs943036 chr10:104836047 T/C cg15744005 chr10:104629667 AS3MT -0.33 -7.05 -0.36 1.08e-11 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs7591163 1.000 rs7591163 chr2:228715375 C/T cg23807890 chr2:228736357 WDR69 -0.51 -7.04 -0.36 1.15e-11 Blood pressure; CRC cis rs1559088 1.000 rs8106453 chr19:33557412 C/T cg27124370 chr19:33622961 WDR88 0.41 5.67 0.3 3.08e-8 Bone ultrasound measurement (broadband ultrasound attenuation); CRC trans rs473976 1.000 rs531438 chr18:40435595 C/T cg09252331 chr1:15655927 FHAD1 -0.46 -6.28 -0.33 1.07e-9 Gut microbiome composition (summer); CRC cis rs968567 0.539 rs174549 chr11:61571382 A/G cg00603274 chr11:61596626 FADS2 0.49 6.88 0.35 3.05e-11 Blood metabolite levels;Rheumatoid arthritis;Vitiligo;Glycerophospholipid levels; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg14638840 chr8:82644585 CHMP4C 0.42 5.99 0.31 5.62e-9 Thyroid stimulating hormone; CRC cis rs8062405 1.000 rs9972693 chr16:28859802 A/G cg16576597 chr16:28551801 NUPR1 0.48 6.83 0.35 4.14e-11 Cognitive ability (multi-trait analysis);Cognitive ability; CRC cis rs9816226 0.587 rs9863591 chr3:185841624 C/G cg00760338 chr3:185826511 ETV5 -0.58 -7.55 -0.38 4.42e-13 Obesity;Body mass index; CRC cis rs17401966 0.597 rs3903151 chr1:10260592 A/G cg19773385 chr1:10388646 KIF1B -0.55 -8.43 -0.42 1.11e-15 Hepatocellular carcinoma; CRC cis rs4731207 0.698 rs6960683 chr7:124530368 C/T cg23710748 chr7:124431027 NA -0.38 -6.06 -0.32 3.65e-9 Cutaneous malignant melanoma; CRC cis rs1448094 0.511 rs17279464 chr12:86164473 C/T cg19622623 chr12:86230825 RASSF9 -0.37 -5.68 -0.3 2.96e-8 Major depressive disorder; CRC cis rs7552404 1.000 rs211718 chr1:76106675 C/T cg22875332 chr1:76189707 ACADM 0.63 8.62 0.43 2.84e-16 Blood metabolite levels;Acylcarnitine levels; CRC cis rs2180341 0.538 rs4577822 chr6:127712911 T/G cg24812749 chr6:127587940 RNF146 0.49 7.18 0.37 4.56e-12 Breast cancer; CRC cis rs294883 0.858 rs6900041 chr6:159715226 G/C cg14500486 chr6:159655392 FNDC1 -0.35 -5.75 -0.3 2.09e-8 Coronary artery disease; CRC cis rs769267 0.930 rs4808208 chr19:19650096 A/G cg03709012 chr19:19516395 GATAD2A 0.73 11.25 0.53 4.69e-25 Tonsillectomy; CRC cis rs9916302 0.904 rs4795359 chr17:37573146 C/T cg15445000 chr17:37608096 MED1 0.43 9.47 0.46 5.8e-19 Glomerular filtration rate (creatinine); CRC cis rs7586879 0.639 rs2033656 chr2:25100902 C/G cg22495460 chr2:25135724 ADCY3 -0.85 -16.22 -0.67 6.71e-44 Body mass index; CRC cis rs2839186 0.843 rs17182671 chr21:47696238 T/C cg09417038 chr21:47716443 C21orf57 -0.42 -6.94 -0.36 2.06e-11 Testicular germ cell tumor; CRC cis rs72945132 0.882 rs7928686 chr11:70134528 T/C cg14191688 chr11:70257035 CTTN 0.4 5.62 0.3 4.07e-8 Coronary artery disease; CRC cis rs7224685 0.501 rs11652060 chr17:4010412 A/T cg10724054 chr17:3904396 NA 0.47 7.59 0.39 3.36e-13 Type 2 diabetes; CRC cis rs909002 0.849 rs10914453 chr1:32075036 A/G cg13919466 chr1:32135498 COL16A1 -0.31 -5.91 -0.31 8.7e-9 Intelligence (multi-trait analysis); CRC cis rs2295359 0.892 rs17375018 chr1:67655147 A/G cg17031739 chr1:67600172 NA -0.4 -6.24 -0.33 1.31e-9 Psoriasis; CRC trans rs7395662 0.963 rs7120743 chr11:48922645 C/T cg21153622 chr11:89784906 NA -0.49 -7.78 -0.39 9.36e-14 HDL cholesterol; CRC cis rs10089 0.953 rs2016015 chr5:127527253 T/C cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.69 9.53 0.46 3.69e-19 Ileal carcinoids; CRC cis rs10540 1.000 rs61877775 chr11:521462 C/T cg03352830 chr11:487213 PTDSS2 0.66 7.13 0.37 6.45e-12 Body mass index; CRC cis rs713587 0.571 rs2917916 chr2:25316336 A/C cg22495460 chr2:25135724 ADCY3 0.39 5.76 0.3 1.89e-8 Body mass index in non-asthmatics; CRC cis rs2032447 0.831 rs9467664 chr6:26021813 A/T cg03264133 chr6:25882463 NA -0.51 -6.9 -0.36 2.64e-11 Intelligence (multi-trait analysis); CRC trans rs7267979 0.789 rs1983974 chr20:25530619 A/C cg17903999 chr18:56338584 MALT1 0.4 6.68 0.35 1.01e-10 Liver enzyme levels (alkaline phosphatase); CRC cis rs868943 0.714 rs13216178 chr6:116392629 T/G cg05304507 chr6:116381966 FRK 0.28 6.37 0.33 6.2e-10 Total cholesterol levels; CRC cis rs728616 0.681 rs56184245 chr10:82018556 C/T cg11900509 chr10:81946545 ANXA11 -0.54 -5.9 -0.31 9.19e-9 Chronic obstructive pulmonary disease-related biomarkers; CRC trans rs1814175 0.646 rs1722010 chr11:49897958 A/G cg11707556 chr5:10655725 ANKRD33B -0.52 -9.95 -0.48 1.5e-20 Height; CRC cis rs7833790 1.000 rs1463259 chr8:82737745 A/G cg27398817 chr8:82754497 SNX16 -0.53 -6.36 -0.33 6.76e-10 Diastolic blood pressure; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg04232674 chr1:150601743 ENSA 0.45 6.09 0.32 3.16e-9 Response to antipsychotic treatment; CRC cis rs9308731 0.644 rs7593638 chr2:111876941 A/C cg18646521 chr2:111875858 NA 0.4 6.31 0.33 8.87e-10 Chronic lymphocytic leukemia; CRC cis rs6502050 0.805 rs4789740 chr17:80119202 T/C cg13198984 chr17:80129470 CCDC57 0.46 8.04 0.41 1.6e-14 Life satisfaction; CRC cis rs4974559 0.793 rs10025954 chr4:1351382 C/T cg02980000 chr4:1222292 CTBP1 0.71 8.18 0.41 6.46e-15 Systolic blood pressure; CRC cis rs6840360 0.642 rs2724567 chr4:152351160 C/T cg09659197 chr4:152720779 NA -0.33 -6.58 -0.34 1.9e-10 Intelligence (multi-trait analysis); CRC cis rs9611565 0.649 rs2064189 chr22:42127999 A/G cg03806693 chr22:41940476 POLR3H 0.64 8.95 0.44 2.68e-17 Vitiligo; CRC trans rs7647973 0.593 rs4855885 chr3:49690199 G/A cg21665057 chr3:196295764 WDR53;FBXO45 -0.62 -6.41 -0.33 5.04e-10 Menarche (age at onset); CRC trans rs10242455 0.702 rs6956305 chr7:99241310 A/G cg09045935 chr12:6379348 NA 0.92 6.84 0.35 3.8e-11 Blood metabolite levels; CRC cis rs2839186 0.587 rs35679325 chr21:47640980 A/G cg13126279 chr21:47581558 C21orf56 0.4 6.09 0.32 3.1e-9 Testicular germ cell tumor; CRC cis rs1153858 1.000 rs12591058 chr15:45640172 T/C cg14582100 chr15:45693742 SPATA5L1 0.28 5.91 0.31 8.48e-9 Homoarginine levels; CRC cis rs6502050 0.835 rs9901076 chr17:80170020 G/A cg02741985 chr17:80059408 CCDC57 0.45 7.36 0.38 1.51e-12 Life satisfaction; CRC cis rs9487051 1.000 rs11757567 chr6:109614713 G/A cg21918786 chr6:109611834 NA -0.38 -6.47 -0.34 3.53e-10 Reticulocyte fraction of red cells; CRC cis rs1448094 0.967 rs10047659 chr12:86338278 C/A cg18827107 chr12:86230957 RASSF9 -0.38 -6.25 -0.33 1.3e-9 Major depressive disorder; CRC cis rs9649213 0.593 rs1076272 chr7:98031005 C/G cg24562669 chr7:97807699 LMTK2 0.42 6.97 0.36 1.78e-11 Prostate cancer (SNP x SNP interaction); CRC cis rs1873147 1.000 rs1873147 chr15:63312632 G/A cg12160578 chr15:63334699 TPM1 -0.4 -5.75 -0.3 2.07e-8 Orofacial clefts; CRC cis rs9894429 0.634 rs9709130 chr17:79583948 C/T cg21028142 chr17:79581711 NPLOC4 0.35 7.24 0.37 3.17e-12 Eye color traits; CRC cis rs6496667 0.779 rs8034045 chr15:90947899 T/C cg04176472 chr15:90893244 GABARAPL3 0.61 8.13 0.41 8.79e-15 Rheumatoid arthritis; CRC cis rs10504229 0.595 rs36081958 chr8:58117505 C/G cg05313129 chr8:58192883 C8orf71 -0.43 -5.95 -0.31 7.03e-9 Developmental language disorder (linguistic errors); CRC cis rs7191700 0.509 rs415595 chr16:11363692 A/G cg00044050 chr16:11439710 C16orf75 0.48 6.58 0.34 1.81e-10 Multiple sclerosis; CRC trans rs1814175 0.626 rs1722008 chr11:49897676 A/T cg21153622 chr11:89784906 NA -0.37 -6.0 -0.31 5.27e-9 Height; CRC cis rs546131 0.928 rs552627 chr11:34826680 G/A cg11058730 chr11:34937778 PDHX;APIP 0.45 6.49 0.34 3.09e-10 Lung disease severity in cystic fibrosis; CRC cis rs6860806 0.661 rs4705929 chr5:131584178 G/T cg12564285 chr5:131593104 PDLIM4 0.48 9.3 0.46 2.06e-18 Breast cancer; CRC cis rs17711722 0.727 rs1880555 chr7:65432567 T/C cg00343986 chr7:65444356 GUSB 0.57 8.65 0.43 2.29e-16 Calcium levels; CRC cis rs7617480 0.648 rs10865953 chr3:48759562 C/T cg20833759 chr3:49053208 WDR6;DALRD3 0.63 9.44 0.46 7.13e-19 Subjective well-being (multi-trait analysis);Menarche (age at onset); CRC cis rs35110281 0.805 rs2838319 chr21:44991901 A/G cg04455712 chr21:45112962 RRP1B 0.4 7.91 0.4 4.03e-14 Mean corpuscular volume; CRC cis rs965469 0.947 rs1854834 chr20:3376619 C/T cg25506879 chr20:3388711 C20orf194 -0.39 -5.63 -0.3 3.94e-8 IFN-related cytopenia; CRC cis rs9916302 0.706 rs6503521 chr17:37715551 A/C cg15445000 chr17:37608096 MED1 -0.35 -5.72 -0.3 2.36e-8 Glomerular filtration rate (creatinine); CRC cis rs6586163 0.843 rs1926199 chr10:90746660 G/T cg03111039 chr10:90751583 FAS;ACTA2 -0.5 -7.21 -0.37 3.77e-12 Chronic lymphocytic leukemia; CRC cis rs1707322 0.963 rs4553121 chr1:46375253 G/A cg03146154 chr1:46216737 IPP 0.51 7.16 0.37 5.32e-12 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs644799 0.896 rs4430471 chr11:95646774 G/A cg25478527 chr11:95522999 CEP57;FAM76B 0.51 7.4 0.38 1.13e-12 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs4319547 0.737 rs10846921 chr12:122943376 G/T cg05707623 chr12:122985044 ZCCHC8 0.6 7.64 0.39 2.4e-13 Body mass index; CRC cis rs1570884 0.516 rs2146144 chr13:50170245 C/T cg08779649 chr13:50194554 NA 0.43 8.96 0.44 2.46e-17 Sum basophil neutrophil counts;Sum neutrophil eosinophil counts;Neutrophil count;Myeloid white cell count;Granulocyte count; CRC cis rs9372498 0.536 rs9489409 chr6:118802721 A/G cg24463073 chr6:118973353 C6orf204 0.51 6.68 0.35 1.04e-10 Diastolic blood pressure; CRC cis rs2836974 0.897 rs2026265 chr21:40595517 G/A cg11890956 chr21:40555474 PSMG1 1.09 18.64 0.72 1.93e-53 Cognitive function; CRC trans rs2235573 0.527 rs139879 chr22:38364552 T/C cg19894588 chr14:64061835 NA 0.53 7.49 0.38 6.32e-13 Glioblastoma;Glioma; CRC cis rs7567389 0.744 rs6430934 chr2:128000833 T/C cg09760422 chr2:128146352 NA -0.36 -6.65 -0.34 1.21e-10 Self-rated health; CRC cis rs1904096 0.506 rs17021463 chr4:95224812 T/G cg11021082 chr4:95130006 SMARCAD1 -0.56 -8.68 -0.43 1.84e-16 Type 2 diabetes; CRC cis rs2204008 0.774 rs11495721 chr12:38337224 A/C cg13010199 chr12:38710504 ALG10B 0.46 6.22 0.32 1.47e-9 Bladder cancer; CRC trans rs9354352 0.967 rs6455062 chr6:66694131 T/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.59 8.61 0.43 3.13e-16 Initial pursuit acceleration in psychotic disorders; CRC cis rs854765 0.583 rs9912895 chr17:17826020 C/T cg04398451 chr17:18023971 MYO15A 0.53 9.7 0.47 1.01e-19 Total body bone mineral density; CRC cis rs7945705 0.846 rs2742540 chr11:8899528 A/G cg00186954 chr11:8933980 ST5;C11orf17 0.49 8.13 0.41 9.12e-15 Hemoglobin concentration; CRC cis rs7193541 0.682 rs28681530 chr16:74682496 C/T cg01733217 chr16:74700730 RFWD3 1.05 21.76 0.77 1.12e-65 Multiple myeloma; CRC cis rs10751667 0.643 rs11246362 chr11:969818 C/T cg23136738 chr11:925521 AP2A2 -0.42 -7.09 -0.36 8.19e-12 Alzheimer's disease (late onset); CRC cis rs1223397 0.651 rs59639740 chr6:13310895 T/G cg20827128 chr6:13274284 PHACTR1 0.38 5.81 0.3 1.5e-8 Blood pressure; CRC cis rs9549367 0.789 rs2287253 chr13:113891075 G/A cg00898013 chr13:113819073 PROZ 0.44 6.54 0.34 2.4e-10 Platelet distribution width; CRC trans rs7618501 1.000 rs7374183 chr3:49785133 G/A cg21659725 chr3:3221576 CRBN -0.92 -17.71 -0.7 8.85e-50 Intelligence (multi-trait analysis); CRC cis rs28386778 0.897 rs8081454 chr17:61842646 A/G cg25654072 chr17:61904446 PSMC5;FTSJ3 0.73 11.3 0.53 2.96e-25 Prudent dietary pattern; CRC cis rs748404 0.650 rs556851 chr15:43571219 A/T cg02155558 chr15:43621948 ADAL;LCMT2 0.44 6.55 0.34 2.15e-10 Lung cancer; CRC cis rs79976124 0.879 rs12214948 chr6:66633603 G/A cg07460842 chr6:66804631 NA 0.78 9.44 0.46 7e-19 Type 2 diabetes; CRC cis rs4664308 0.935 rs877200 chr2:160903723 G/C cg03641300 chr2:160917029 PLA2R1 -0.72 -12.01 -0.55 8.64e-28 Idiopathic membranous nephropathy; CRC cis rs938554 0.513 rs1014290 chr4:10001861 G/A cg11266682 chr4:10021025 SLC2A9 0.33 5.97 0.31 6.16e-9 Blood metabolite levels; CRC cis rs7618915 0.547 rs4130905 chr3:52709831 A/T cg07507251 chr3:52567010 NT5DC2 0.46 6.6 0.34 1.68e-10 Bipolar disorder; CRC cis rs4970988 0.607 rs7548516 chr1:150980281 C/T cg15448220 chr1:150897856 SETDB1 -0.5 -6.08 -0.32 3.38e-9 Urate levels; CRC cis rs4713118 0.824 rs2092075 chr6:27749330 G/C cg21251018 chr6:28226885 NKAPL 0.42 6.06 0.32 3.81e-9 Parkinson's disease; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg06092729 chr12:64845451 TBK1 0.4 6.19 0.32 1.81e-9 Intelligence (multi-trait analysis); CRC cis rs6988636 1.000 rs62521841 chr8:124194625 G/A cg27053337 chr8:124217698 FAM83A 0.42 5.97 0.31 6.24e-9 Urinary uromodulin levels; CRC cis rs7769051 0.522 rs56908272 chr6:133102165 G/C cg22852734 chr6:133119734 C6orf192 0.96 7.4 0.38 1.13e-12 Type 2 diabetes nephropathy; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg21715088 chr18:74534568 NA 0.5 6.85 0.35 3.67e-11 Anxiety disorder; CRC trans rs2235573 0.527 rs139866 chr22:38354684 C/T cg19894588 chr14:64061835 NA 0.53 7.49 0.38 6.32e-13 Glioblastoma;Glioma; CRC cis rs10504229 0.728 rs17804822 chr8:58156276 T/C cg24829409 chr8:58192753 C8orf71 -0.6 -8.06 -0.41 1.4e-14 Developmental language disorder (linguistic errors); CRC cis rs1799949 0.965 rs35954893 chr17:41333786 A/G cg23758822 chr17:41437982 NA 0.79 13.57 0.6 1.3e-33 Menopause (age at onset); CRC cis rs7647973 0.626 rs9870858 chr3:49769071 C/T cg13072238 chr3:49761600 GMPPB -0.48 -5.68 -0.3 2.89e-8 Menarche (age at onset); CRC cis rs17253792 0.545 rs75276278 chr14:56024341 C/T cg01858014 chr14:56050164 KTN1 -0.86 -6.61 -0.34 1.56e-10 Putamen volume; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg20707008 chr6:160210612 MRPL18;TCP1 0.49 6.44 0.33 4.12e-10 Thyroid stimulating hormone; CRC cis rs853679 0.542 rs6934769 chr6:28090931 A/G cg12963246 chr6:28129442 ZNF389 0.49 5.78 0.3 1.73e-8 Depression; CRC cis rs6121246 0.559 rs6060919 chr20:30331922 A/T cg13852791 chr20:30311386 BCL2L1 0.76 15.43 0.65 8.47e-41 Mean corpuscular hemoglobin; CRC cis rs1552244 0.882 rs13099136 chr3:10031431 G/A cg13047869 chr3:10149882 C3orf24 0.52 6.98 0.36 1.6e-11 Alzheimer's disease; CRC cis rs4665809 0.590 rs4665315 chr2:26416036 T/G cg22920501 chr2:26401640 FAM59B -0.82 -11.68 -0.54 1.37e-26 Gut microbiome composition (summer); CRC cis rs7692995 1.000 rs12513324 chr4:18006951 C/T cg08925142 chr4:18023851 LCORL -0.55 -6.07 -0.32 3.53e-9 Height; CRC cis rs6502050 0.835 rs12938965 chr17:80128646 G/A cg13198984 chr17:80129470 CCDC57 0.46 8.13 0.41 9e-15 Life satisfaction; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg17510133 chr11:17298268 NUCB2 0.46 6.5 0.34 2.99e-10 Anxiety disorder; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg22261612 chr11:117187137 BACE1 0.37 6.13 0.32 2.45e-9 Liver disease severity in Alagille syndrome; CRC cis rs7618915 0.547 rs11130311 chr3:52675005 T/C cg05573699 chr3:52720067 GNL3;PBRM1 -0.47 -6.68 -0.35 1.02e-10 Bipolar disorder; CRC cis rs78456975 1.000 rs7584264 chr2:1565555 A/G cg26248373 chr2:1572462 NA -0.7 -8.19 -0.41 5.66e-15 Placebo response in major depressive disorder (% change in symptom score); CRC cis rs2832191 0.740 rs13048618 chr21:30458684 A/G cg24692254 chr21:30365293 RNF160 0.85 16.15 0.67 1.24e-43 Dental caries; CRC cis rs4332037 0.539 rs55790766 chr7:2021248 C/T cg02421172 chr7:1938701 MAD1L1 0.42 5.67 0.3 3.12e-8 Bipolar disorder; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg17766062 chr2:75062663 HK2 0.46 6.16 0.32 2.1e-9 Thyroid stimulating hormone; CRC cis rs875971 0.862 rs801203 chr7:66023012 A/G cg11764359 chr7:65958608 NA -0.59 -8.82 -0.44 6.62e-17 Aortic root size; CRC cis rs6741819 0.617 rs4669127 chr2:7160439 G/A cg27144453 chr2:7172511 RNF144A -0.56 -7.64 -0.39 2.37e-13 Response to antipsychotic treatment; CRC cis rs951366 0.764 rs708724 chr1:205743663 A/C cg26354017 chr1:205819088 PM20D1 0.74 11.35 0.53 2.08e-25 Menarche (age at onset); CRC cis rs13256369 1.000 rs10103769 chr8:8573036 G/T cg06636001 chr8:8085503 FLJ10661 0.46 5.8 0.3 1.53e-8 Obesity-related traits; CRC cis rs1348850 0.914 rs9789582 chr2:178330173 C/G cg22681709 chr2:178499509 PDE11A -0.4 -7.25 -0.37 2.94e-12 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs35306767 0.953 rs11253520 chr10:975961 C/G cg20503657 chr10:835505 NA -0.51 -7.16 -0.37 5.15e-12 Eosinophil percentage of granulocytes; CRC cis rs7927592 0.913 rs3740629 chr11:68343593 C/T cg16797656 chr11:68205561 LRP5 0.36 5.73 0.3 2.27e-8 Total body bone mineral density; CRC cis rs4234284 0.556 rs7650549 chr3:126968288 C/T cg27326032 chr3:127006922 NA -0.53 -7.67 -0.39 2.02e-13 Adverse response to chemotherapy in breast cancer (alopecia) (docetaxel); CRC trans rs6703335 0.870 rs10803142 chr1:243598234 A/G cg19315081 chr11:10326100 ADM 0.42 6.28 0.33 1.09e-9 Schizophrenia;Schizophrenia, schizoaffective disorder or bipolar disorder; CRC cis rs7107770 0.739 rs4936994 chr11:125081440 G/C cg27629782 chr11:125073726 PKNOX2 0.53 7.85 0.4 6.04e-14 Photic sneeze reflex; CRC cis rs10128264 0.902 rs1250587 chr10:80978021 A/G cg18737081 chr10:80999807 ZMIZ1 -0.37 -6.52 -0.34 2.67e-10 Response to methotrexate in juvenile idiopathic arthritis; CRC cis rs11098499 0.908 rs7696649 chr4:120322177 G/A cg09307838 chr4:120376055 NA 0.71 10.97 0.52 4.67e-24 Corneal astigmatism; CRC cis rs10463316 0.817 rs10476770 chr5:150777720 G/C cg03212797 chr5:150827313 SLC36A1 -0.46 -7.14 -0.37 5.85e-12 Metabolite levels (Pyroglutamine); CRC trans rs10983614 1.000 rs7867776 chr9:120072627 A/G cg08023809 chr12:53645616 MFSD5 0.47 6.28 0.33 1.06e-9 Survival in pancreatic cancer; CRC cis rs4481887 0.962 rs10788769 chr1:248457426 C/T cg13385794 chr1:248469461 NA 0.39 6.99 0.36 1.52e-11 Common traits (Other); CRC cis rs1707322 0.686 rs2050376 chr1:46078630 C/T cg03146154 chr1:46216737 IPP 0.65 9.04 0.45 1.33e-17 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs8040855 0.965 rs11073990 chr15:85711301 C/T cg04831495 chr15:85060580 GOLGA6L5 -0.38 -5.81 -0.3 1.51e-8 Bulimia nervosa; CRC cis rs9902453 0.933 rs9898353 chr17:28451865 T/C cg26525008 chr17:28256777 EFCAB5;SSH2 0.61 9.61 0.47 1.97e-19 Coffee consumption (cups per day); CRC cis rs362272 0.524 rs3129334 chr4:3368526 T/C cg02993699 chr4:3415135 RGS12 -0.41 -6.58 -0.34 1.8e-10 Serum sulfate level; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg17071181 chr3:171757786 FNDC3B 0.39 6.08 0.32 3.27e-9 Liver disease severity in Alagille syndrome; CRC cis rs2404602 0.536 rs7163946 chr15:76766049 C/G cg22467129 chr15:76604101 ETFA -0.44 -7.55 -0.38 4.43e-13 Blood metabolite levels; CRC cis rs6952808 0.689 rs79950306 chr7:2022063 C/G cg22963979 chr7:1858916 MAD1L1 -0.51 -7.33 -0.37 1.83e-12 Bipolar disorder and schizophrenia; CRC cis rs2050392 0.799 rs2907 chr10:30728250 A/G cg25182066 chr10:30743637 MAP3K8 -0.41 -6.08 -0.32 3.4e-9 Inflammatory bowel disease; CRC cis rs853679 0.574 rs1233705 chr6:28166447 C/G cg15845792 chr6:28175446 NA 1.02 15.66 0.65 1.12e-41 Depression; CRC cis rs950776 0.518 rs12910100 chr15:78822667 C/T cg06917634 chr15:78832804 PSMA4 0.66 10.42 0.5 3.55e-22 Sudden cardiac arrest; CRC cis rs6502050 0.835 rs8070014 chr17:80115247 T/G cg22110888 chr17:80059540 CCDC57 0.4 6.48 0.34 3.37e-10 Life satisfaction; CRC cis rs7412746 0.611 rs36008098 chr1:150856806 G/A cg10589385 chr1:150898437 SETDB1 0.28 5.94 0.31 7.44e-9 Melanoma; CRC cis rs2153535 0.580 rs4960421 chr6:8459292 C/T cg21535247 chr6:8435926 SLC35B3 0.51 7.9 0.4 4.36e-14 Motion sickness; CRC cis rs2230307 0.536 rs57637634 chr1:100447467 G/A cg24955406 chr1:100503596 HIAT1 0.54 6.51 0.34 2.76e-10 Carotid intima media thickness; CRC cis rs7772486 0.875 rs10457796 chr6:146416087 T/G cg13319975 chr6:146136371 FBXO30 -0.39 -6.06 -0.32 3.8e-9 Lobe attachment (rater-scored or self-reported); CRC trans rs2842895 0.735 rs4585612 chr6:7153152 C/T cg17652435 chr17:36103066 HNF1B -0.37 -6.04 -0.32 4.23e-9 Visceral adipose tissue adjusted for BMI;Visceral adipose tissue/subcutaneous adipose tissue ratio adjusted for BMI; CRC cis rs11030122 0.702 rs7950153 chr11:3951337 T/C cg18678763 chr11:4115507 RRM1 -0.48 -7.95 -0.4 2.92e-14 Mean platelet volume;Platelet distribution width; CRC cis rs9814567 0.806 rs13076825 chr3:134317239 G/A cg06541857 chr3:134203789 ANAPC13;CEP63 0.37 5.67 0.3 3.08e-8 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs2067615 0.560 rs10431462 chr12:107106546 G/A cg13491945 chr12:107078410 RFX4 0.35 6.01 0.31 5e-9 Heart rate; CRC cis rs2976388 0.507 rs2572874 chr8:143837219 C/T cg24046110 chr8:143859143 LYNX1 0.59 10.44 0.5 3.06e-22 Urinary tract infection frequency; CRC trans rs4591358 0.648 rs17177798 chr2:196386076 A/G cg12742475 chr15:75233485 NA 0.31 6.27 0.33 1.15e-9 Adverse response to chemotherapy (neutropenia/leucopenia) (all antimicrotubule drugs); CRC cis rs10751667 0.666 rs7395182 chr11:927553 A/C cg06064525 chr11:970664 AP2A2 -0.33 -6.65 -0.34 1.25e-10 Alzheimer's disease (late onset); CRC cis rs72772090 0.539 rs111886458 chr5:96125047 G/A cg17330273 chr5:96107758 CAST;ERAP1 -0.63 -5.96 -0.31 6.43e-9 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs10883723 0.810 rs7072351 chr10:104265047 C/T cg22532475 chr10:104410764 TRIM8 -0.36 -6.44 -0.33 4.17e-10 Allergic disease (asthma, hay fever or eczema); CRC cis rs35306767 0.714 rs7075188 chr10:1088746 G/T cg20503657 chr10:835505 NA -0.59 -8.07 -0.41 1.29e-14 Eosinophil percentage of granulocytes; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg11355319 chr5:89825117 LYSMD3 0.45 6.45 0.34 3.99e-10 Response to antipsychotic treatment; CRC cis rs78456975 0.527 rs11901028 chr2:1557972 A/G cg12573674 chr2:1569213 NA -0.82 -10.55 -0.5 1.33e-22 Placebo response in major depressive disorder (% change in symptom score); CRC cis rs798554 0.634 rs1182180 chr7:2873279 G/T cg17321639 chr7:2759063 NA -0.37 -5.62 -0.3 4.14e-8 Height; CRC cis rs1005277 0.579 rs9299760 chr10:38377920 C/T cg00409905 chr10:38381863 ZNF37A -0.67 -11.2 -0.53 7.11e-25 Extrinsic epigenetic age acceleration; CRC cis rs10791323 0.569 rs2257004 chr11:133712473 C/T cg15485101 chr11:133734466 NA 0.44 7.53 0.38 4.86e-13 Childhood ear infection; CRC cis rs9905704 0.647 rs3809723 chr17:57061978 T/G cg12560992 chr17:57184187 TRIM37 0.62 9.38 0.46 1.07e-18 Testicular germ cell tumor; CRC cis rs2882667 0.898 rs11956089 chr5:138394604 G/T cg04439458 chr5:138467593 SIL1 0.33 6.0 0.31 5.18e-9 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs1448094 0.935 rs10746355 chr12:86330227 A/T cg18827107 chr12:86230957 RASSF9 -0.38 -6.21 -0.32 1.58e-9 Major depressive disorder; CRC cis rs28386778 0.863 rs58269663 chr17:61843130 G/A cg22520471 chr17:61851767 DDX42;CCDC47 0.74 11.57 0.54 3.22e-26 Prudent dietary pattern; CRC cis rs6503525 0.628 rs4065985 chr17:38101932 G/C cg26162295 chr17:38119207 GSDMA -0.37 -6.71 -0.35 8.6e-11 Asthma; CRC cis rs6752107 0.936 rs10178603 chr2:234206610 G/A cg07618928 chr2:234183455 ATG16L1;SCARNA5 0.59 9.48 0.46 5.36e-19 Crohn's disease;Inflammatory bowel disease; CRC cis rs877282 0.891 rs12767062 chr10:797961 C/T cg06581033 chr10:766294 NA -0.51 -5.71 -0.3 2.49e-8 Uric acid levels; CRC cis rs7737355 0.947 rs3776027 chr5:130802970 T/C cg06307176 chr5:131281290 NA -0.42 -6.27 -0.33 1.11e-9 Life satisfaction; CRC cis rs60871478 0.898 rs62432225 chr7:789433 G/A cg05535760 chr7:792225 HEATR2 0.91 11.34 0.53 2.2e-25 Cerebrospinal P-tau181p levels; CRC cis rs12630931 0.895 rs13099369 chr3:31982251 C/G cg21375017 chr3:31988082 OSBPL10 0.42 5.76 0.3 1.94e-8 Periodontal disease-related phenotypes; CRC cis rs875971 0.660 rs12698534 chr7:65986845 C/T cg00343986 chr7:65444356 GUSB 0.49 7.42 0.38 1.01e-12 Aortic root size; CRC cis rs9814567 1.000 rs55913793 chr3:134285968 G/T cg06109529 chr3:134205091 CEP63;ANAPC13 -0.82 -12.35 -0.56 4.64e-29 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs2455601 0.786 rs10279 chr11:8969309 T/C cg09997546 chr11:8931473 C11orf17;ST5 -0.45 -6.06 -0.32 3.71e-9 Schizophrenia; CRC cis rs875971 0.545 rs4718325 chr7:65680310 G/A cg03233332 chr7:66118400 NA -0.43 -5.95 -0.31 6.69e-9 Aortic root size; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg01069804 chr15:63449582 RPS27L 0.43 6.09 0.32 3.17e-9 Intelligence (multi-trait analysis); CRC cis rs8078723 0.668 rs3859191 chr17:38128714 G/A cg17344932 chr17:38183730 MED24;SNORD124 -0.52 -8.37 -0.42 1.64e-15 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); CRC cis rs2011503 0.882 rs72999053 chr19:19375372 G/A cg11584989 chr19:19387371 SF4 0.6 6.76 0.35 6.25e-11 Bipolar disorder; CRC trans rs916888 0.779 rs430685 chr17:44859148 T/C cg01341218 chr17:43662625 NA -0.83 -9.39 -0.46 1.03e-18 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs2243480 1.000 rs160652 chr7:65538431 A/G cg18252515 chr7:66147081 NA -1.21 -14.12 -0.61 1.06e-35 Diabetic kidney disease; CRC cis rs798554 0.797 rs798486 chr7:2803037 A/G cg19346786 chr7:2764209 NA -0.39 -6.75 -0.35 6.62e-11 Height; CRC cis rs1153858 1.000 rs4627277 chr15:45652768 C/A cg10760299 chr15:45669010 GATM 0.52 8.37 0.42 1.66e-15 Homoarginine levels; CRC cis rs6074578 0.541 rs6077481 chr20:149975 C/T cg16931068 chr20:139680 DEFB127 0.28 5.64 0.3 3.74e-8 Hirschsprung disease; CRC cis rs10504229 0.545 rs56394419 chr8:58128982 T/C cg04204079 chr8:58130323 NA -0.45 -5.78 -0.3 1.71e-8 Developmental language disorder (linguistic errors); CRC cis rs7772486 0.875 rs2474356 chr6:146296798 G/A cg23711669 chr6:146136114 FBXO30 0.67 11.51 0.54 5.29e-26 Lobe attachment (rater-scored or self-reported); CRC cis rs6424115 0.931 rs2473377 chr1:24148260 T/C cg09473613 chr1:24152604 HMGCL 0.35 5.85 0.31 1.22e-8 Immature fraction of reticulocytes; CRC cis rs13118159 0.550 rs4974611 chr4:1358449 T/C cg02018176 chr4:1364513 KIAA1530 0.73 12.61 0.57 5.08e-30 Longevity; CRC cis rs3772130 1.000 rs11721318 chr3:121429485 G/A cg20356878 chr3:121714668 ILDR1 0.51 7.75 0.39 1.19e-13 Cognitive performance; CRC cis rs826838 1.000 rs826838 chr12:39106731 C/T cg13010199 chr12:38710504 ALG10B -0.41 -6.1 -0.32 2.99e-9 Heart rate; CRC cis rs13118159 0.872 rs1882105 chr4:1345956 T/C cg24560729 chr4:1342394 KIAA1530 0.43 7.47 0.38 7.22e-13 Longevity; CRC cis rs2019216 0.542 rs8073228 chr17:21909838 C/G cg05591447 chr17:21909280 FLJ36000 -0.31 -5.96 -0.31 6.45e-9 Pelvic organ prolapse; CRC cis rs11098499 0.863 rs10013305 chr4:120450424 G/A cg09307838 chr4:120376055 NA 0.69 10.34 0.5 6.68e-22 Corneal astigmatism; CRC cis rs2842992 0.692 rs1128661 chr6:160211554 T/G cg16489826 chr6:160211363 TCP1;MRPL18 0.61 8.99 0.44 1.94e-17 Age-related macular degeneration (geographic atrophy); CRC cis rs116095464 0.558 rs7714335 chr5:263513 T/C cg22496380 chr5:211416 CCDC127 -0.78 -8.75 -0.43 1.13e-16 Breast cancer; CRC cis rs2370759 1.000 rs79806114 chr10:32618022 T/C cg01819863 chr10:32635814 EPC1 1.14 13.54 0.6 1.72e-33 Sexual dysfunction (female); CRC cis rs2243480 0.615 rs34363376 chr7:65939536 T/C cg25985355 chr7:65971099 NA -0.54 -6.04 -0.32 4.13e-9 Diabetic kidney disease; CRC cis rs6952808 0.500 rs3778996 chr7:2177190 G/A cg22963979 chr7:1858916 MAD1L1 -0.41 -5.75 -0.3 2.09e-8 Bipolar disorder and schizophrenia; CRC trans rs916888 0.779 rs199498 chr17:44865603 A/G cg22968622 chr17:43663579 NA 1.04 13.3 0.59 1.37e-32 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs6951245 1.000 rs28399710 chr7:1070631 G/T cg04025307 chr7:1156635 C7orf50 0.63 6.63 0.34 1.41e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs7202877 0.706 rs42472 chr16:75473320 T/A cg03315344 chr16:75512273 CHST6 -0.5 -5.81 -0.31 1.46e-8 Type 2 diabetes;Type 1 diabetes; CRC trans rs10504229 1.000 rs114486414 chr8:58185103 G/A cg04077850 chr5:125800366 GRAMD3 0.37 6.27 0.33 1.15e-9 Developmental language disorder (linguistic errors); CRC cis rs10865541 0.902 rs10206964 chr2:3425948 T/C cg22182287 chr2:3452347 TTC15 0.4 6.27 0.33 1.11e-9 Obesity-related traits; CRC cis rs1552244 0.882 rs7636817 chr3:10014876 G/T cg02579736 chr3:10068473 FANCD2;CIDECP 0.94 12.02 0.55 8e-28 Alzheimer's disease; CRC cis rs9674544 0.757 rs6504593 chr17:47132819 T/C cg10950924 chr17:47092072 IGF2BP1 -0.35 -5.8 -0.3 1.56e-8 Primary tooth development (time to first tooth eruption);Primary tooth development (number of teeth); CRC cis rs10463316 0.894 rs6579865 chr5:150762335 A/C cg03212797 chr5:150827313 SLC36A1 -0.5 -7.78 -0.39 9.41e-14 Metabolite levels (Pyroglutamine); CRC cis rs629535 0.814 rs488231 chr8:70064993 T/C cg26132723 chr8:70041827 NA 0.36 5.82 0.31 1.41e-8 Dupuytren's disease; CRC cis rs7247513 0.897 rs12979146 chr19:12717904 C/T cg01871581 chr19:12707946 ZNF490 -0.84 -15.47 -0.65 6.1e-41 Bipolar disorder; CRC cis rs7312933 0.703 rs10492388 chr12:42608001 T/C cg11827402 chr12:42719852 PPHLN1;ZCRB1 0.66 9.27 0.46 2.49e-18 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CRC cis rs1506636 1.000 rs641491 chr7:123399726 C/A cg03229431 chr7:123269106 ASB15 0.73 11.64 0.54 1.85e-26 Plateletcrit;Platelet count; CRC cis rs2243480 1.000 rs1796220 chr7:66062100 C/T cg12463550 chr7:65579703 CRCP 0.66 6.0 0.31 5.22e-9 Diabetic kidney disease; CRC cis rs8180040 0.587 rs1466741 chr3:47247214 C/T cg27129171 chr3:47204927 SETD2 -0.7 -11.15 -0.52 1.04e-24 Colorectal cancer; CRC cis rs2576037 0.583 rs9304336 chr18:44461687 T/C cg19077165 chr18:44547161 KATNAL2 -0.64 -11.1 -0.52 1.59e-24 Personality dimensions; CRC cis rs3731896 0.653 rs908194 chr2:220198247 A/G cg00436969 chr2:220197716 RESP18 -0.46 -5.82 -0.31 1.37e-8 Educational attainment; CRC cis rs4481887 0.927 rs10888343 chr1:248446642 A/G cg13385794 chr1:248469461 NA 0.39 6.63 0.34 1.4e-10 Common traits (Other); CRC cis rs4731207 0.565 rs12538641 chr7:124600671 A/G cg23710748 chr7:124431027 NA -0.38 -6.08 -0.32 3.27e-9 Cutaneous malignant melanoma; CRC cis rs2979489 0.891 rs2915592 chr8:30396417 C/T cg26383811 chr8:30366931 RBPMS -0.7 -10.27 -0.49 1.19e-21 Mean corpuscular hemoglobin;Plateletcrit;Neutrophil count;Granulocyte count;Sum basophil neutrophil counts;Mean corpuscular volume;Myeloid white cell count;Sum neutrophil eosinophil counts; CRC cis rs9303280 0.901 rs883770 chr17:38063381 C/T cg11212589 chr17:38028394 ZPBP2 0.45 8.28 0.42 3.21e-15 Self-reported allergy; CRC cis rs2274273 0.870 rs1109170 chr14:55785788 A/C cg23234261 chr14:55582407 NA -0.29 -5.78 -0.3 1.73e-8 Protein biomarker; CRC trans rs208520 0.754 rs1100989 chr6:66880532 G/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.03 -14.15 -0.62 7.62e-36 Exhaled nitric oxide output; CRC cis rs11098499 0.954 rs10014845 chr4:120301077 T/G cg09307838 chr4:120376055 NA 0.71 10.93 0.52 6.41e-24 Corneal astigmatism; CRC cis rs950776 0.518 rs2869544 chr15:78839400 G/A cg06917634 chr15:78832804 PSMA4 -0.66 -10.57 -0.5 1.08e-22 Sudden cardiac arrest; CRC cis rs3816788 0.774 rs11784816 chr8:21773500 C/T cg16476235 chr8:21771668 DOK2 -0.41 -7.14 -0.37 6.1e-12 Lung cancer in ever smokers; CRC cis rs2204008 0.905 rs7294297 chr12:38442573 T/C cg13010199 chr12:38710504 ALG10B 0.45 6.02 0.31 4.73e-9 Bladder cancer; CRC cis rs9322193 0.962 rs9765929 chr6:150090816 T/C cg05861140 chr6:150128134 PCMT1 -0.44 -7.18 -0.37 4.53e-12 Lung cancer; CRC cis rs72627509 0.904 rs3796529 chr4:57797414 C/T cg26694713 chr4:57773883 REST 0.46 5.7 0.3 2.63e-8 Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); CRC cis rs7274811 0.711 rs184110 chr20:31981432 G/A cg03904042 chr20:32255491 NECAB3;C20orf134 0.43 6.3 0.33 9.73e-10 Height; CRC cis rs13096480 0.583 rs17598137 chr3:49891362 G/T cg04073039 chr3:49158377 USP19 0.4 5.95 0.31 6.99e-9 Intelligence (multi-trait analysis); CRC cis rs2239547 0.522 rs2710345 chr3:52976075 T/C cg18404041 chr3:52824283 ITIH1 0.34 6.39 0.33 5.78e-10 Schizophrenia; CRC cis rs7927771 0.965 rs4752881 chr11:47898535 A/G cg20307385 chr11:47447363 PSMC3 -0.5 -6.57 -0.34 2.01e-10 Subjective well-being; CRC cis rs10242455 0.702 rs3823813 chr7:99049389 G/A cg18809830 chr7:99032528 PTCD1 -1.27 -8.96 -0.44 2.42e-17 Blood metabolite levels; CRC cis rs9322193 0.886 rs4039600 chr6:149897455 A/G cg05861140 chr6:150128134 PCMT1 -0.4 -6.39 -0.33 5.6e-10 Lung cancer; CRC cis rs2153535 0.580 rs7753192 chr6:8482637 G/A cg21535247 chr6:8435926 SLC35B3 0.5 7.48 0.38 6.86e-13 Motion sickness; CRC cis rs875971 1.000 rs1981798 chr7:65954903 G/T cg18912574 chr7:65842487 NCRNA00174 0.35 5.94 0.31 7.17e-9 Aortic root size; CRC cis rs12024301 0.557 rs10911395 chr1:183634257 C/A cg11505048 chr1:183622726 RGL1;APOBEC4 0.81 7.0 0.36 1.42e-11 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs7772486 0.774 rs6930181 chr6:146180974 A/T cg05347473 chr6:146136440 FBXO30 -0.38 -5.94 -0.31 7.27e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs9522267 0.535 rs9522305 chr13:112237550 A/G cg10483660 chr13:112241077 NA -0.48 -9.1 -0.45 9.18e-18 Hepatitis; CRC cis rs9399135 0.967 rs9376082 chr6:135346389 T/A cg24558204 chr6:135376177 HBS1L 0.52 8.24 0.41 4.03e-15 Red blood cell count; CRC cis rs7178572 1.000 rs2055901 chr15:77759295 G/A cg22256960 chr15:77711686 NA -0.7 -10.84 -0.51 1.34e-23 Type 2 diabetes; CRC cis rs9467711 0.539 rs34436535 chr6:26370365 G/C cg16898833 chr6:26189333 HIST1H4D 0.76 6.58 0.34 1.88e-10 Autism spectrum disorder or schizophrenia; CRC cis rs6952407 1 rs6952407 chr7:66045512 A/G cg25985355 chr7:65971099 NA 0.33 5.62 0.3 4.08e-8 Cotinine glucuronidation; CRC cis rs9322193 0.962 rs13215691 chr6:150113802 T/C cg13206674 chr6:150067644 NUP43 0.53 7.51 0.38 5.65e-13 Lung cancer; CRC cis rs2721195 0.654 rs4610795 chr8:145881333 C/T cg15320075 chr8:145703422 NA -0.5 -7.92 -0.4 3.73e-14 Age at first birth; CRC cis rs2243480 1.000 rs1392104 chr7:65759107 G/A cg25985355 chr7:65971099 NA 0.51 5.72 0.3 2.46e-8 Diabetic kidney disease; CRC cis rs4862750 0.957 rs4861733 chr4:187903933 C/T cg22105103 chr4:187893119 NA 0.64 11.17 0.52 9.2e-25 Lobe attachment (rater-scored or self-reported); CRC cis rs2032447 0.517 rs7767546 chr6:25904067 T/C cg18357526 chr6:26021779 HIST1H4A 0.55 7.39 0.38 1.21e-12 Intelligence (multi-trait analysis); CRC trans rs877282 0.838 rs34778553 chr10:796865 T/C cg22713356 chr15:30763199 NA 1.34 16.88 0.68 1.71e-46 Uric acid levels; CRC trans rs797680 0.856 rs6541404 chr1:93743434 A/T cg05406791 chr12:10875874 CSDA 0.36 6.11 0.32 2.89e-9 Eosinophil percentage of white cells;Sum eosinophil basophil counts; CRC cis rs2463822 0.844 rs1919359 chr11:62055703 A/G cg06239285 chr11:62104954 ASRGL1 0.96 10.02 0.48 8.1899999999999992e-21 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs9916302 0.904 rs11078915 chr17:37715426 T/C cg03013999 chr17:37608204 MED1 0.47 7.31 0.37 2.05e-12 Glomerular filtration rate (creatinine); CRC cis rs881375 0.967 rs7039505 chr9:123705945 A/T cg14255062 chr9:123606675 PSMD5;LOC253039 0.4 5.84 0.31 1.28e-8 Rheumatoid arthritis; CRC cis rs801193 1.000 rs7788576 chr7:66148302 G/A cg18876405 chr7:65276391 NA -0.61 -10.75 -0.51 2.65e-23 Aortic root size; CRC cis rs7772486 0.790 rs2253764 chr6:146199881 T/A cg13319975 chr6:146136371 FBXO30 -0.42 -6.31 -0.33 8.97e-10 Lobe attachment (rater-scored or self-reported); CRC cis rs7772486 0.754 rs4895682 chr6:146062861 G/A cg13319975 chr6:146136371 FBXO30 0.49 7.16 0.37 5.26e-12 Lobe attachment (rater-scored or self-reported); CRC cis rs6076065 0.683 rs2424556 chr20:23419556 C/T cg11657817 chr20:23433608 CST11 0.44 6.56 0.34 2.11e-10 Facial morphology (factor 15, philtrum width); CRC cis rs10486722 0.606 rs10951658 chr7:41788734 A/G cg22138096 chr7:41772439 LOC285954 0.46 5.99 0.31 5.49e-9 Pit-and-Fissure caries; CRC cis rs1348850 0.874 rs1348848 chr2:178358233 A/C cg02961200 chr2:178257176 LOC100130691;AGPS -0.62 -9.25 -0.45 3.02e-18 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs4443100 0.670 rs3788338 chr22:23412058 G/A cg14186256 chr22:23484241 RTDR1 0.45 5.82 0.31 1.36e-8 Serum parathyroid hormone levels; CRC cis rs6903823 0.527 rs4713158 chr6:28277771 C/A cg06470822 chr6:28175283 NA 0.49 6.73 0.35 7.72e-11 Pulmonary function; CRC cis rs2333194 0.772 rs8016034 chr14:73812188 C/A cg19682024 chr14:74008259 HEATR4;ACOT1 -0.39 -5.88 -0.31 9.99e-9 Bipolar disorder with mood-incongruent psychosis; CRC cis rs6088580 0.634 rs6087580 chr20:32992592 A/G cg08999081 chr20:33150536 PIGU -0.62 -11.35 -0.53 2.08e-25 Glomerular filtration rate (creatinine); CRC cis rs4713118 0.527 rs4713151 chr6:28136356 G/A cg03623178 chr6:28175578 NA 0.98 12.66 0.57 3.31e-30 Parkinson's disease; CRC cis rs4728302 0.869 rs13233715 chr7:133617471 C/T cg03336402 chr7:133662267 EXOC4 -0.45 -6.49 -0.34 3.21e-10 Intelligence;Intelligence (multi-trait analysis); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg06586599 chr19:7587541 MCOLN1 0.39 6.0 0.31 5.1e-9 Intelligence (multi-trait analysis); CRC cis rs13256369 1.000 rs4841016 chr8:8572561 C/T cg06636001 chr8:8085503 FLJ10661 0.46 5.82 0.31 1.39e-8 Obesity-related traits; CRC cis rs1865760 0.566 rs2032449 chr6:26026599 G/C cg17691542 chr6:26056736 HIST1H1C 0.54 8.23 0.41 4.36e-15 Height; CRC cis rs7546094 0.967 rs351372 chr1:113059220 A/T cg22162597 chr1:113214053 CAPZA1 0.42 5.94 0.31 7.33e-9 Platelet distribution width; CRC cis rs6499255 0.951 rs12595869 chr16:69729794 T/G cg15192750 chr16:69999425 NA 0.58 7.82 0.4 7.29e-14 IgE levels; CRC cis rs2228479 0.850 rs17233664 chr16:89810628 C/T cg06656553 chr16:89960601 TCF25 -0.68 -5.71 -0.3 2.55e-8 Skin colour saturation; CRC cis rs8177253 1.000 rs8177262 chr3:133480652 A/G cg01448562 chr3:133502909 NA 0.54 9.23 0.45 3.43e-18 Iron status biomarkers; CRC cis rs597539 0.652 rs584108 chr11:68630282 A/T cg06028808 chr11:68637592 NA -0.38 -6.0 -0.31 5.14e-9 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs2032447 0.839 rs199751 chr6:26015583 T/C cg04800585 chr6:26043546 HIST1H2BB 0.58 8.7 0.43 1.58e-16 Intelligence (multi-trait analysis); CRC cis rs523522 0.962 rs2235218 chr12:120888619 A/C cg12219531 chr12:120966889 COQ5 0.63 8.33 0.42 2.22e-15 High light scatter reticulocyte count; CRC cis rs1799949 0.965 rs1842147 chr17:41435192 C/T cg05368731 chr17:41323189 NBR1 0.64 9.16 0.45 5.68e-18 Menopause (age at onset); CRC cis rs12497850 0.864 rs4521268 chr3:49137904 G/T cg07636037 chr3:49044803 WDR6 1.0 16.32 0.67 2.68e-44 Parkinson's disease; CRC cis rs57221529 0.766 rs4081846 chr5:574019 G/A cg14541582 chr5:601475 NA -0.34 -6.66 -0.34 1.17e-10 Lung disease severity in cystic fibrosis; CRC cis rs10499694 0.933 rs11575356 chr7:50594821 T/C cg14593290 chr7:50529359 DDC -0.43 -6.34 -0.33 7.76e-10 Body mass index; CRC cis rs881375 0.678 rs10760129 chr9:123700183 T/C cg09419670 chr9:123605666 PSMD5;LOC253039 0.51 8.16 0.41 7.4e-15 Rheumatoid arthritis; CRC cis rs4727027 0.933 rs62505074 chr7:148834780 C/T cg23583168 chr7:148888333 NA -0.88 -14.79 -0.63 2.76e-38 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC cis rs1865760 0.566 rs2794720 chr6:26087202 G/C cg16482183 chr6:26056742 HIST1H1C 0.52 7.58 0.39 3.66e-13 Height; CRC cis rs6089584 0.546 rs6061978 chr20:60615604 C/T cg06108461 chr20:60628389 TAF4 -0.76 -12.45 -0.57 2.03e-29 Body mass index; CRC cis rs1448094 0.717 rs55811543 chr12:86290936 C/T cg19622623 chr12:86230825 RASSF9 -0.42 -6.71 -0.35 8.51e-11 Major depressive disorder; CRC cis rs13108904 0.901 rs2293634 chr4:1291711 T/G cg02018176 chr4:1364513 KIAA1530 0.38 6.34 0.33 7.65e-10 Obesity-related traits; CRC cis rs172166 0.694 rs203892 chr6:28067196 T/C cg21251018 chr6:28226885 NKAPL 0.47 7.26 0.37 2.83e-12 Cardiac Troponin-T levels; CRC cis rs7103648 0.669 rs7927445 chr11:47780754 G/T cg20307385 chr11:47447363 PSMC3 0.75 10.26 0.49 1.33e-21 Diastolic blood pressure;Systolic blood pressure; CRC cis rs6570726 0.791 rs441290 chr6:145883183 A/G cg13319975 chr6:146136371 FBXO30 -0.43 -6.39 -0.33 5.79e-10 Lobe attachment (rater-scored or self-reported); CRC cis rs7193541 0.859 rs12598791 chr16:74500745 A/C cg01733217 chr16:74700730 RFWD3 0.84 15.13 0.64 1.27e-39 Multiple myeloma; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg10243681 chr15:73925924 NPTN 0.41 6.01 0.31 5.04e-9 Intelligence (multi-trait analysis); CRC cis rs4953076 0.533 rs1551315 chr2:44407618 G/A cg04920474 chr2:44395004 PPM1B 0.56 7.8 0.39 8.41e-14 Height; CRC trans rs1499614 1.000 rs2707840 chr7:66158015 C/T cg10756647 chr7:56101905 PSPH 0.77 8.1 0.41 1.09e-14 Gout; CRC cis rs7312774 0.748 rs7295619 chr12:107316934 T/A cg16260113 chr12:107380972 MTERFD3 0.74 7.38 0.38 1.29e-12 Severe influenza A (H1N1) infection; CRC cis rs10979 0.571 rs9386039 chr6:143916992 A/T cg25407410 chr6:143891975 LOC285740 0.59 7.62 0.39 2.65e-13 Hypospadias; CRC cis rs7731657 0.537 rs13355837 chr5:130360537 C/T cg08523029 chr5:130500466 HINT1 -0.45 -5.83 -0.31 1.3e-8 Fasting plasma glucose; CRC cis rs10256972 0.621 rs2363285 chr7:1091644 C/T cg02869364 chr7:1081709 C7orf50 -0.37 -6.14 -0.32 2.33e-9 Longevity;Endometriosis; CRC cis rs7072216 0.881 rs2182168 chr10:100148353 C/G cg26618903 chr10:100175079 PYROXD2 -0.37 -6.2 -0.32 1.66e-9 Metabolite levels; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg22459930 chr17:6544061 TXNDC17;KIAA0753 0.4 5.99 0.31 5.57e-9 Response to antipsychotic treatment; CRC cis rs3820068 0.581 rs1547033 chr1:15918988 T/C cg13390004 chr1:15929781 NA 0.5 6.9 0.36 2.6e-11 Systolic blood pressure; CRC cis rs62064224 0.560 rs12162135 chr17:30805795 A/C cg09324608 chr17:30823087 MYO1D 0.38 6.62 0.34 1.48e-10 Schizophrenia; CRC cis rs709400 0.593 rs12898029 chr14:103877884 T/C cg12935359 chr14:103987150 CKB 0.52 8.44 0.42 9.98e-16 Body mass index; CRC cis rs6502050 0.805 rs4789721 chr17:80157453 T/C cg09264619 chr17:80180166 NA -0.36 -6.1 -0.32 3e-9 Life satisfaction; CRC cis rs9399135 0.967 rs6915770 chr6:135369214 G/A cg24558204 chr6:135376177 HBS1L 0.49 7.75 0.39 1.18e-13 Red blood cell count; CRC cis rs875971 1.000 rs1544549 chr7:66090663 T/A cg18876405 chr7:65276391 NA -0.53 -8.8 -0.44 7.76e-17 Aortic root size; CRC cis rs896854 0.654 rs13248607 chr8:95986637 T/G cg23172400 chr8:95962367 TP53INP1 -0.47 -7.84 -0.4 6.44e-14 Type 2 diabetes; CRC cis rs9611565 0.921 rs2143695 chr22:41728620 A/G cg03806693 chr22:41940476 POLR3H -0.7 -9.89 -0.48 2.31e-20 Vitiligo; CRC cis rs2841233 0.692 rs2028416 chr14:105348552 C/T cg16576083 chr14:105354267 KIAA0284 0.46 8.01 0.4 1.95e-14 IgG glycosylation; CRC cis rs372883 0.532 rs388707 chr21:30714776 T/C cg24692254 chr21:30365293 RNF160 -0.44 -6.5 -0.34 3.04e-10 Pancreatic cancer; CRC trans rs2727020 0.595 rs11040328 chr11:49339055 T/C cg03929089 chr4:120376271 NA -0.64 -9.84 -0.48 3.51e-20 Coronary artery disease; CRC cis rs9549328 0.699 rs2993345 chr13:113617086 C/T cg20742385 chr13:113633654 MCF2L 0.56 9.53 0.46 3.72e-19 Systolic blood pressure; CRC cis rs9457247 0.534 rs2757053 chr6:167380338 A/C cg23791538 chr6:167370224 RNASET2 0.5 8.04 0.41 1.67e-14 Crohn's disease; CRC cis rs875971 0.522 rs4718286 chr7:65292764 A/G cg11764359 chr7:65958608 NA 0.51 7.86 0.4 5.44e-14 Aortic root size; CRC cis rs6570726 0.791 rs6570695 chr6:145911286 C/A cg23711669 chr6:146136114 FBXO30 0.68 11.28 0.53 3.51e-25 Lobe attachment (rater-scored or self-reported); CRC cis rs8038465 0.516 rs8037836 chr15:73859855 G/A cg15420318 chr15:73925796 NPTN 0.52 8.62 0.43 2.78e-16 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs747650 0.798 rs11039086 chr11:47116033 G/C cg03339077 chr11:47165057 C11orf49 0.48 6.94 0.36 2.1e-11 Acne (severe); CRC cis rs28386778 0.897 rs894407 chr17:61901641 T/C cg06873352 chr17:61820015 STRADA 0.77 14.46 0.62 5e-37 Prudent dietary pattern; CRC cis rs10504229 0.593 rs2317990 chr8:58024168 G/T cg02725872 chr8:58115012 NA -0.44 -6.61 -0.34 1.51e-10 Developmental language disorder (linguistic errors); CRC cis rs8060686 0.623 rs7205935 chr16:68152157 A/G cg26727032 chr16:67993705 SLC12A4 -0.62 -9.66 -0.47 1.32e-19 HDL cholesterol;Metabolic syndrome; CRC cis rs7208859 0.573 rs7214313 chr17:29138596 T/C cg13385521 chr17:29058706 SUZ12P 0.71 8.21 0.41 5.14e-15 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs35306767 0.855 rs34318754 chr10:890714 G/A cg26597838 chr10:835615 NA 1.26 14.66 0.63 8.53e-38 Eosinophil percentage of granulocytes; CRC cis rs6772849 0.930 rs6768344 chr3:128373556 G/A cg08795948 chr3:128337044 NA 0.35 6.17 0.32 1.95e-9 Monocyte percentage of white cells;Monocyte count; CRC cis rs4319547 0.728 rs61954974 chr12:123074169 T/C cg23029597 chr12:123009494 RSRC2 -0.62 -7.77 -0.39 9.78e-14 Body mass index; CRC cis rs6988985 0.560 rs5301 chr8:143955273 T/C cg10324643 chr8:143916377 GML 0.39 6.58 0.34 1.85e-10 Plasma androstenedione levels in resected early stage-receptor positive breast cancer; CRC cis rs1552244 1.000 rs7615764 chr3:10082592 C/T cg10729496 chr3:10149963 C3orf24 0.55 7.11 0.37 7.07e-12 Alzheimer's disease; CRC cis rs2404602 0.692 rs4641709 chr15:77047736 C/T cg23625390 chr15:77176239 SCAPER -0.46 -6.55 -0.34 2.19e-10 Blood metabolite levels; CRC cis rs6752107 0.935 rs1596017 chr2:234147930 C/T cg07618928 chr2:234183455 ATG16L1;SCARNA5 0.54 8.4 0.42 1.36e-15 Crohn's disease;Inflammatory bowel disease; CRC trans rs6833159 0.527 rs10939231 chr4:28829372 A/T cg08929303 chr1:207227076 PFKFB2 -0.33 -6.7 -0.35 9.13e-11 Underweight status; CRC cis rs1059312 1.000 rs7136092 chr12:129280164 G/C cg21616243 chr12:129299702 MGC16384;SLC15A4 -0.66 -10.81 -0.51 1.69e-23 Systemic lupus erythematosus; CRC trans rs12478296 1.000 rs56292923 chr2:243039986 C/T cg18288967 chr1:45987694 PRDX1 0.69 7.68 0.39 1.79e-13 Obesity-related traits; CRC cis rs10986311 0.706 rs7851278 chr9:127102939 T/G cg14243010 chr9:127117328 LOC100129034;PSMB7 0.4 5.95 0.31 6.72e-9 Vitiligo; CRC cis rs838147 0.537 rs504963 chr19:49208865 G/A cg21064579 chr19:49206444 FUT2 0.48 8.33 0.42 2.23e-15 Dietary macronutrient intake; CRC cis rs1865760 0.865 rs9467641 chr6:25947236 T/C cg16482183 chr6:26056742 HIST1H1C 0.52 7.37 0.38 1.41e-12 Height; CRC cis rs6582630 0.519 rs1607882 chr12:38361657 G/A cg26384229 chr12:38710491 ALG10B 0.67 9.82 0.48 3.88e-20 Drug-induced liver injury (flucloxacillin); CRC cis rs9783347 0.925 rs3802968 chr11:18343878 A/G cg15585147 chr11:18324498 HPS5 0.45 6.34 0.33 7.44e-10 Pancreatic cancer; CRC cis rs7589728 0.514 rs12465706 chr2:88467459 C/A cg04511125 chr2:88470314 THNSL2 0.81 8.56 0.43 4.31e-16 Plasma clusterin levels; CRC cis rs10504229 0.906 rs7842482 chr8:58167720 A/T cg05313129 chr8:58192883 C8orf71 -0.46 -7.52 -0.38 5.35e-13 Developmental language disorder (linguistic errors); CRC cis rs992157 1.000 rs4674280 chr2:219141458 C/G cg00012203 chr2:219082015 ARPC2 -0.54 -8.81 -0.44 7.44e-17 Colorectal cancer; CRC trans rs10983614 1.000 rs7867776 chr9:120072627 A/G cg25152348 chr22:50946712 NCAPH2;LMF2 0.53 7.58 0.39 3.63e-13 Survival in pancreatic cancer; CRC cis rs7809950 1.000 rs6976607 chr7:107223401 A/C cg23024343 chr7:107201750 COG5 0.62 9.0 0.44 1.79e-17 Coronary artery disease; CRC cis rs847577 0.748 rs13221897 chr7:97719699 G/A cg21770322 chr7:97807741 LMTK2 0.84 18.44 0.71 1.15e-52 Breast cancer; CRC cis rs7085104 0.632 rs6162 chr10:104596981 G/A cg15744005 chr10:104629667 AS3MT -0.34 -7.17 -0.37 4.98e-12 Immature fraction of reticulocytes;Schizophrenia; CRC cis rs7666738 0.830 rs28417577 chr4:99053007 T/C cg17366294 chr4:99064904 C4orf37 0.45 7.75 0.39 1.16e-13 Colonoscopy-negative controls vs population controls; CRC cis rs12983728 0.505 rs35511051 chr19:58665817 C/A cg21294424 chr19:58662284 ZNF329 0.5 6.36 0.33 6.88e-10 Cholesterol, total; CRC cis rs6500602 0.598 rs3859155 chr16:4593741 A/C cg14951292 chr16:4525986 HMOX2;NMRAL1 -0.49 -7.33 -0.37 1.83e-12 Schizophrenia; CRC cis rs4665809 0.590 rs10197494 chr2:26445550 A/G cg25036284 chr2:26402008 FAM59B -0.61 -7.76 -0.39 1.09e-13 Gut microbiome composition (summer); CRC cis rs4654899 0.733 rs10442633 chr1:21265097 C/T cg02927042 chr1:21476669 EIF4G3 -0.38 -6.09 -0.32 3.21e-9 Superior frontal gyrus grey matter volume; CRC cis rs9443645 0.836 rs9352676 chr6:79629999 A/G cg11833968 chr6:79620685 NA -0.37 -6.4 -0.33 5.34e-10 Intelligence (multi-trait analysis); CRC cis rs1707322 1.000 rs785480 chr1:46492164 C/G cg03146154 chr1:46216737 IPP 0.5 6.98 0.36 1.66e-11 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs1728785 1.000 rs1099296 chr16:68588653 G/A cg02972257 chr16:68554789 NA -0.61 -7.61 -0.39 2.89e-13 Ulcerative colitis; CRC cis rs9443189 0.615 rs6453829 chr6:76268509 C/T cg01950844 chr6:76311363 SENP6 0.71 9.25 0.45 2.99e-18 Prostate cancer; CRC cis rs2806561 1.000 rs2806561 chr1:23504795 C/T cg19743168 chr1:23544995 NA -0.4 -6.36 -0.33 6.58e-10 Height; CRC cis rs3091242 0.933 rs9438904 chr1:25756860 T/C cg27572855 chr1:25598939 RHD 0.34 6.08 0.32 3.36e-9 Erythrocyte sedimentation rate; CRC cis rs7635838 0.654 rs346086 chr3:11272932 G/T cg00170343 chr3:11313890 ATG7 0.56 8.47 0.42 8.49e-16 HDL cholesterol; CRC cis rs11122272 0.735 rs2486734 chr1:231531392 A/G cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.58 -8.72 -0.43 1.37e-16 Hemoglobin concentration; CRC cis rs17155006 0.702 rs418255 chr7:107730034 A/G cg05962710 chr7:107745446 LAMB4 -0.36 -5.88 -0.31 9.91e-9 Pneumococcal bacteremia; CRC cis rs60843830 1.000 rs4497901 chr2:239969 C/T cg00108164 chr2:264199 ACP1;SH3YL1 0.62 10.07 0.49 5.72e-21 Spherical equivalent (joint analysis main effects and education interaction); CRC cis rs422249 0.547 rs174533 chr11:61549025 G/A cg00603274 chr11:61596626 FADS2 -0.44 -6.39 -0.33 5.71e-10 Trans fatty acid levels; CRC cis rs7762018 0.556 rs78864023 chr6:170059755 T/A cg19338460 chr6:170058176 WDR27 -1.21 -11.42 -0.53 1.14e-25 Thiazide-induced adverse metabolic effects in hypertensive patients; CRC cis rs9487051 0.714 rs7744284 chr6:109616218 C/T cg01475377 chr6:109611718 NA -0.39 -6.79 -0.35 5.17e-11 Reticulocyte fraction of red cells; CRC cis rs9868809 0.505 rs28657585 chr3:48736216 A/T cg00383909 chr3:49044727 WDR6 0.77 8.16 0.41 7.02e-15 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; CRC trans rs10982213 0.830 rs2274163 chr9:117188714 C/T cg00694302 chr12:47609865 LOC100233209;FAM113B 0.47 7.04 0.36 1.15e-11 Interleukin-6 levels; CRC cis rs1707322 0.682 rs10890334 chr1:46100378 A/T cg03146154 chr1:46216737 IPP 0.67 9.75 0.47 6.55e-20 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs12143943 0.934 rs12027855 chr1:204595544 C/A cg17419461 chr1:204415978 PIK3C2B 0.43 6.86 0.35 3.34e-11 Cognitive performance; CRC cis rs694739 1.000 rs11231757 chr11:64106317 C/T cg23796481 chr11:64053134 BAD;GPR137 0.57 8.55 0.43 4.85e-16 Alopecia areata;Crohn's disease;Psoriasis vulgaris; CRC trans rs877282 0.945 rs10904555 chr10:787740 C/A cg22713356 chr15:30763199 NA 1.35 16.39 0.67 1.43e-44 Uric acid levels; CRC cis rs6964587 0.692 rs4729018 chr7:91644613 C/T cg17063962 chr7:91808500 NA 0.62 10.03 0.48 7.81e-21 Breast cancer; CRC cis rs4363385 0.747 rs9919276 chr1:152968654 A/T cg25856811 chr1:152973957 SPRR3 -0.27 -7.38 -0.38 1.3e-12 Inflammatory skin disease; CRC cis rs921968 0.565 rs12611632 chr2:219621258 C/T cg02176678 chr2:219576539 TTLL4 -0.39 -6.31 -0.33 8.83e-10 Mean corpuscular hemoglobin concentration; CRC cis rs10751667 1.000 rs7396798 chr11:970510 G/T ch.11.42038R chr11:967971 AP2A2 0.68 11.43 0.53 1.1e-25 Alzheimer's disease (late onset); CRC cis rs12135062 0.901 rs2651928 chr1:3101722 C/T cg00254258 chr1:3105189 PRDM16 -0.56 -9.63 -0.47 1.65e-19 Migraine; CRC cis rs7647973 0.554 rs13096480 chr3:49658084 A/G cg03060546 chr3:49711283 APEH 0.68 8.22 0.41 4.71e-15 Menarche (age at onset); CRC trans rs7395662 0.929 rs10839173 chr11:48930758 C/T cg21153622 chr11:89784906 NA -0.49 -7.78 -0.39 9.36e-14 HDL cholesterol; CRC cis rs4423214 1.000 rs12422045 chr11:71154820 C/T cg05163923 chr11:71159392 DHCR7 0.66 9.84 0.48 3.28e-20 Vitamin D levels; CRC cis rs7043114 0.544 rs12335553 chr9:95297871 A/C cg14631576 chr9:95140430 CENPP -0.32 -5.95 -0.31 6.89e-9 Height; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg16148674 chr11:14380065 RRAS2 -0.4 -6.1 -0.32 3.03e-9 Myopia (pathological); CRC cis rs62064224 0.554 rs9894877 chr17:30679517 T/A cg21839984 chr17:30846986 MYO1D -0.33 -5.62 -0.3 4.03e-8 Schizophrenia; CRC trans rs34421088 0.560 rs2467520 chr8:11398953 T/C cg16141378 chr3:129829833 LOC729375 0.47 6.93 0.36 2.19e-11 Neuroticism; CRC cis rs9039 0.921 rs9929699 chr16:9218270 A/G cg08831531 chr16:9218945 NA -0.56 -7.8 -0.4 8.3e-14 Menopause (age at onset); CRC trans rs7267979 1.000 rs2482941 chr20:25361216 T/C cg17903999 chr18:56338584 MALT1 0.41 6.54 0.34 2.39e-10 Liver enzyme levels (alkaline phosphatase); CRC cis rs1552172 0.887 rs12750384 chr1:145681484 T/C cg11743829 chr1:145714124 CD160 -0.43 -6.46 -0.34 3.75e-10 Breast cancer; CRC cis rs12541635 0.639 rs10955408 chr8:107020789 G/A cg10147462 chr8:107024639 NA 0.57 10.1 0.49 4.39e-21 Age of smoking initiation; CRC cis rs35110281 0.693 rs4819290 chr21:45122713 C/T cg21573476 chr21:45109991 RRP1B -0.39 -5.85 -0.31 1.19e-8 Mean corpuscular volume; CRC cis rs10883723 0.810 rs10786671 chr10:104271303 G/A cg22532475 chr10:104410764 TRIM8 -0.37 -6.81 -0.35 4.65e-11 Allergic disease (asthma, hay fever or eczema); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg14032529 chr10:114712217 TCF7L2 0.42 6.98 0.36 1.66e-11 Liver disease severity in Alagille syndrome; CRC cis rs7202877 0.706 rs467780 chr16:75437138 A/G cg03315344 chr16:75512273 CHST6 -0.5 -6.04 -0.32 4.22e-9 Type 2 diabetes;Type 1 diabetes; CRC cis rs561341 0.941 rs8066558 chr17:30272879 G/T cg23018236 chr17:30244563 NA -0.58 -7.85 -0.4 6.09e-14 Hip circumference adjusted for BMI; CRC cis rs11098499 0.644 rs6855918 chr4:120546299 C/T cg09307838 chr4:120376055 NA 0.61 9.27 0.46 2.51e-18 Corneal astigmatism; CRC cis rs8180040 0.627 rs9821119 chr3:47198437 C/G cg02527881 chr3:46936655 PTH1R -0.35 -6.09 -0.32 3.07e-9 Colorectal cancer; CRC cis rs2288073 0.562 rs112892911 chr2:24590800 G/A cg06627628 chr2:24431161 ITSN2 -0.8 -11.17 -0.52 9.24e-25 Venous thromboembolism (SNP x SNP interaction); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg20563921 chr11:62420975 INTS5 0.5 7.07 0.36 9.41e-12 Response to antipsychotic treatment; CRC cis rs7131987 0.650 rs6487808 chr12:29463359 C/T cg09582351 chr12:29534625 ERGIC2 0.31 6.59 0.34 1.78e-10 QT interval; CRC cis rs1568889 1.000 rs61889026 chr11:28274803 G/A cg06544937 chr11:28130018 METT5D1;KIF18A 0.77 9.73 0.47 7.78e-20 Bipolar disorder; CRC cis rs6545883 0.894 rs4672423 chr2:61435275 C/T cg15711740 chr2:61764176 XPO1 0.42 5.66 0.3 3.27e-8 Tuberculosis; CRC cis rs2404602 0.692 rs1471780 chr15:77026526 T/C cg23625390 chr15:77176239 SCAPER 0.47 6.71 0.35 8.51e-11 Blood metabolite levels; CRC cis rs11252926 0.966 rs61831030 chr10:578869 C/T cg18196295 chr10:418757 DIP2C -0.54 -7.4 -0.38 1.12e-12 Psychosis in Alzheimer's disease; CRC cis rs763014 0.966 rs4984677 chr16:671682 A/G cg02475695 chr16:616220 NHLRC4 0.46 7.59 0.39 3.22e-13 Height; CRC cis rs875971 0.895 rs6460278 chr7:65662736 T/C cg00343986 chr7:65444356 GUSB -0.47 -6.52 -0.34 2.69e-10 Aortic root size; CRC cis rs6499255 0.904 rs10852458 chr16:69672410 G/A cg15192750 chr16:69999425 NA 0.47 6.57 0.34 2.01e-10 IgE levels; CRC cis rs629535 0.814 rs614050 chr8:70065642 G/A cg26132723 chr8:70041827 NA 0.36 5.82 0.31 1.41e-8 Dupuytren's disease; CRC cis rs8060686 0.858 rs1109166 chr16:67977382 T/C cg07125278 chr16:67683757 RLTPR -0.47 -6.1 -0.32 2.98e-9 HDL cholesterol;Metabolic syndrome; CRC cis rs9467773 1.000 rs1321480 chr6:26532742 A/G cg09904177 chr6:26538194 HMGN4 0.85 14.67 0.63 7.49e-38 Intelligence (multi-trait analysis); CRC cis rs10504229 0.728 rs17804822 chr8:58156276 T/C cg20607798 chr8:58055168 NA 0.46 5.75 0.3 2.06e-8 Developmental language disorder (linguistic errors); CRC cis rs875971 0.895 rs10755833 chr7:65913917 A/G cg18876405 chr7:65276391 NA 0.52 8.85 0.44 5.32e-17 Aortic root size; CRC cis rs780094 0.528 rs1728918 chr2:27635463 C/T cg03023068 chr2:27486122 SLC30A3 0.39 5.86 0.31 1.1e-8 Calcium levels;Fasting blood insulin;Metabolic traits;Triglyceride levels;Fasting plasma glucose;Urate levels in overweight individuals;Urate levels in obese individuals;Uric acid levels;Height;Age-related diseases, mortality and associated endophenotypes;Renal underexcretion gout;Fasting blood glucose (BMI interaction);Urate levels;Gondoic acid (20:1n-9) levels;Fasting blood insulin (BMI interaction);Triglycerides;Plasma omega-3 polyunsaturated fatty acid levels (docosapentaenoic acid);Type 2 diabetes;Nonalcoholic fatty liver disease;Hypertriglyceridemia;C-reactive protein;Age-related disease endophenotypes;LDL cholesterol;Metabolic syndrome;Crohn's disease;Alcohol consumption (drinks per week);Homeostasis model assessment of insulin resistance;Alcohol consumption;Red blood cell count;Fasting blood glucose; CRC cis rs7412746 0.658 rs7521719 chr1:150913134 G/A cg15448220 chr1:150897856 SETDB1 0.56 8.18 0.41 6.08e-15 Melanoma; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg00679716 chr14:23067188 ABHD4 0.47 6.59 0.34 1.76e-10 Response to antipsychotic treatment; CRC cis rs16975963 0.793 rs11666497 chr19:38464262 C/T cg15135657 chr19:38346511 NA -0.44 -5.8 -0.3 1.56e-8 Longevity; CRC cis rs10992471 0.580 rs12341093 chr9:95234182 G/T cg14631576 chr9:95140430 CENPP -0.41 -7.34 -0.37 1.73e-12 Visceral adipose tissue/subcutaneous adipose tissue ratio; CRC cis rs972578 0.837 rs4822201 chr22:43227272 T/G cg01576275 chr22:43409880 NA -0.4 -6.34 -0.33 7.73e-10 Mean platelet volume; CRC cis rs7309 0.935 rs10930013 chr2:162070325 G/A cg16506815 chr2:162101123 NA 0.52 8.58 0.43 3.85e-16 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Educational attainment; CRC cis rs936229 0.690 rs2472299 chr15:75033400 C/T cg14664628 chr15:75095509 CSK 0.83 14.33 0.62 1.64e-36 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); CRC cis rs7412746 0.611 rs4509581 chr1:150774465 A/G cg15448220 chr1:150897856 SETDB1 0.52 7.3 0.37 2.16e-12 Melanoma; CRC cis rs10504229 0.511 rs75967910 chr8:58024231 C/G cg21724239 chr8:58056113 NA 0.78 9.68 0.47 1.17e-19 Developmental language disorder (linguistic errors); CRC cis rs3820068 0.581 rs34453754 chr1:15993208 G/C cg27534772 chr1:16042836 PLEKHM2 0.54 10.11 0.49 4.15e-21 Systolic blood pressure; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg21852761 chr6:130340620 L3MBTL3 0.38 6.04 0.32 4.08e-9 Liver disease severity in Alagille syndrome; CRC cis rs1691799 0.899 rs1168315 chr12:66746694 A/G cg16791601 chr12:66731901 HELB -0.73 -12.99 -0.58 1.9e-31 White blood cell count (basophil); CRC cis rs1976403 0.633 rs1697422 chr1:21821897 T/C cg00786952 chr1:21763130 NA 0.49 8.25 0.41 3.95e-15 Liver enzyme levels (alkaline phosphatase); CRC cis rs11711311 0.826 rs13077644 chr3:113467777 G/A cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.52 -7.18 -0.37 4.66e-12 IgG glycosylation; CRC cis rs4563143 0.514 rs73029076 chr19:29292032 G/T cg03161606 chr19:29218774 NA 0.54 6.2 0.32 1.68e-9 Methadone dose in opioid dependence; CRC trans rs10504229 0.861 rs57942497 chr8:58171239 G/T cg04077850 chr5:125800366 GRAMD3 0.37 6.27 0.33 1.15e-9 Developmental language disorder (linguistic errors); CRC cis rs2294693 1.000 rs2294693 chr6:41005502 T/C cg14769373 chr6:40998127 UNC5CL -0.44 -5.85 -0.31 1.19e-8 Gastric cancer;Non-cardia gastric cancer; CRC cis rs910316 0.737 rs398896 chr14:75482827 C/A cg08847533 chr14:75593920 NEK9 -0.85 -14.43 -0.62 6.29e-37 Height; CRC cis rs225245 0.782 rs178649 chr17:33908197 C/G cg05299278 chr17:33885742 SLFN14 0.47 7.76 0.39 1.08e-13 Reticulocyte count;Reticulocyte fraction of red cells;High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells; CRC cis rs7615952 0.599 rs2333408 chr3:125732098 G/A cg02772935 chr3:125709198 NA -0.48 -6.03 -0.32 4.36e-9 Blood pressure (smoking interaction); CRC cis rs2204008 0.712 rs12371182 chr12:38321143 A/C cg13010199 chr12:38710504 ALG10B 0.44 5.63 0.3 3.82e-8 Bladder cancer; CRC cis rs1552244 0.572 rs41464050 chr3:10158393 A/G cg18598329 chr3:10140678 FANCD2;C3orf24 -0.91 -10.95 -0.52 5.12e-24 Alzheimer's disease; CRC cis rs2243480 0.901 rs34807232 chr7:65965133 G/A cg25985355 chr7:65971099 NA -0.52 -5.98 -0.31 5.81e-9 Diabetic kidney disease; CRC cis rs9462846 0.919 rs9462851 chr6:42890602 A/G cg21280719 chr6:42927975 GNMT -0.32 -5.96 -0.31 6.49e-9 Blood protein levels; CRC cis rs3806843 0.966 rs10053945 chr5:140160127 C/T cg19875535 chr5:140030758 IK 0.6 9.79 0.48 4.86e-20 Depressive symptoms (multi-trait analysis); CRC cis rs9393777 0.528 rs35982103 chr6:27243134 C/T cg12292205 chr6:26970375 C6orf41 -0.8 -8.75 -0.43 1.1e-16 Intelligence (multi-trait analysis); CRC cis rs8180040 0.966 rs1872164 chr3:47415100 G/A cg02527881 chr3:46936655 PTH1R 0.37 6.77 0.35 5.97e-11 Colorectal cancer; CRC cis rs6912958 0.781 rs2273129 chr6:88182439 T/C cg08069147 chr6:88032118 GJB7;C6orf162 -0.56 -8.3 -0.42 2.79e-15 Monocyte percentage of white cells; CRC trans rs561341 0.769 rs9899093 chr17:30191954 C/G cg20587970 chr11:113659929 NA -1.02 -12.09 -0.55 4.3e-28 Hip circumference adjusted for BMI; CRC cis rs12760731 0.720 rs12037817 chr1:178261750 A/G cg00404053 chr1:178313656 RASAL2 0.93 9.67 0.47 1.27e-19 Obesity-related traits; CRC cis rs9814567 1.000 rs6766818 chr3:134226159 C/T cg06541857 chr3:134203789 ANAPC13;CEP63 -0.4 -6.1 -0.32 2.91e-9 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC trans rs11673344 0.528 rs491326 chr19:37410939 G/A cg18947437 chr10:1231002 ADARB2 -0.36 -6.39 -0.33 5.73e-10 Obesity-related traits; CRC cis rs13064411 0.660 rs3829889 chr3:113015464 G/A cg10517650 chr3:113235015 CCDC52 -0.38 -6.03 -0.32 4.48e-9 Response to simvastatin treatment (PCSK9 protein level change); CRC cis rs2739330 0.760 rs5760095 chr22:24247293 A/G cg11905131 chr22:24372483 LOC391322 -0.68 -10.47 -0.5 2.49e-22 Liver enzyme levels (gamma-glutamyl transferase); CRC trans rs4276421 0.806 rs13169726 chr5:45445069 G/A cg04793272 chr11:119020941 ABCG4 -0.39 -6.42 -0.33 4.83e-10 P wave duration; CRC cis rs6674176 0.628 rs7556565 chr1:44416090 C/T cg13606994 chr1:44402422 ARTN -0.36 -5.99 -0.31 5.51e-9 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Cognitive ability; CRC cis rs11190604 0.806 rs76835764 chr10:102193612 C/T cg07080220 chr10:102295463 HIF1AN 0.5 6.31 0.33 9.07e-10 Palmitoleic acid (16:1n-7) levels; CRC cis rs6502050 0.835 rs4789751 chr17:80092373 G/T cg19223190 chr17:80058835 NA 0.4 6.32 0.33 8.57e-10 Life satisfaction; CRC trans rs2303319 0.504 rs56009150 chr2:162598582 T/C cg13490827 chr1:46269305 MAST2 -0.69 -6.05 -0.32 4.03e-9 Cognitive function; CRC cis rs3204270 0.639 rs62077183 chr17:79658940 C/A cg18367735 chr17:79674897 NA 0.48 5.67 0.3 3.17e-8 Dental caries; CRC cis rs1862618 0.853 rs2113078 chr5:56087190 C/T cg18230493 chr5:56204884 C5orf35 -0.76 -9.75 -0.47 6.9e-20 Initial pursuit acceleration; CRC cis rs11212617 0.967 rs7118967 chr11:108057856 G/A cg12106634 chr11:108092400 ATM;NPAT 0.38 5.71 0.3 2.48e-8 Response to metformin in type 2 diabetes (glycemic); CRC cis rs875971 0.545 rs1909508 chr7:65766353 G/T cg11764359 chr7:65958608 NA 0.47 6.01 0.31 4.85e-9 Aortic root size; CRC cis rs9381040 0.610 rs2268196 chr6:41021950 C/G cg25110423 chr6:41068646 NFYA;LOC221442 0.38 5.89 0.31 9.57e-9 Alzheimer's disease (late onset); CRC cis rs7666738 0.830 rs7657497 chr4:99044028 A/G cg17366294 chr4:99064904 C4orf37 0.45 7.73 0.39 1.34e-13 Colonoscopy-negative controls vs population controls; CRC cis rs9322193 0.962 rs1413655 chr6:150142951 A/G cg13206674 chr6:150067644 NUP43 0.57 7.98 0.4 2.4e-14 Lung cancer; CRC cis rs9359856 0.662 rs1179904 chr6:90322573 A/G cg13799429 chr6:90582589 CASP8AP2 0.64 9.38 0.46 1.09e-18 Bipolar disorder; CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg26685501 chr1:38019921 SNIP1 0.43 6.77 0.35 5.91e-11 Obesity-related traits; CRC cis rs2976388 0.609 rs2585153 chr8:143785345 G/A cg24046110 chr8:143859143 LYNX1 0.5 8.67 0.43 1.94e-16 Urinary tract infection frequency; CRC cis rs3540 0.512 rs7176518 chr15:91079637 C/T cg22089800 chr15:90895588 ZNF774 -0.57 -9.33 -0.46 1.66e-18 Allergic disease (asthma, hay fever or eczema);Lymphocyte counts; CRC cis rs709400 0.930 rs57447494 chr14:104034569 G/A cg08213375 chr14:104286397 PPP1R13B -0.34 -5.72 -0.3 2.42e-8 Body mass index; CRC cis rs7223966 1.000 rs7216798 chr17:61740963 G/A cg23903597 chr17:61704154 MAP3K3 -0.43 -5.85 -0.31 1.19e-8 Hip circumference adjusted for BMI;Body mass index; CRC cis rs4523957 0.928 rs216183 chr17:2173923 A/G cg16513277 chr17:2031491 SMG6 0.55 9.34 0.46 1.53e-18 Autism spectrum disorder or schizophrenia;Schizophrenia; CRC cis rs7493 1.000 rs2158806 chr7:95051998 A/C cg19678392 chr7:94953810 PON1 -0.59 -7.31 -0.37 2.09e-12 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs12142240 0.698 rs56284503 chr1:46847127 C/G cg00530320 chr1:46809349 NSUN4 0.59 8.07 0.41 1.35e-14 Menopause (age at onset); CRC cis rs939574 0.790 rs72955444 chr2:220094673 T/G cg00496455 chr2:220118770 TUBA4A;TUBA4B 0.91 8.44 0.42 1.06e-15 Platelet distribution width; CRC cis rs1887596 0.705 rs2776435 chr13:27217535 T/C cg01312412 chr13:27282625 NA 0.42 5.77 0.3 1.86e-8 Facial morphology (factor 3, length of philtrum); CRC cis rs6772849 0.896 rs9816260 chr3:128352083 A/T cg08795948 chr3:128337044 NA 0.36 6.28 0.33 1.04e-9 Monocyte percentage of white cells;Monocyte count; CRC cis rs9399137 0.507 rs12663447 chr6:135317026 A/C cg22676075 chr6:135203613 NA 0.59 9.01 0.45 1.66e-17 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; CRC cis rs2832191 0.636 rs8131295 chr21:30516819 A/T cg08807101 chr21:30365312 RNF160 -0.53 -7.31 -0.37 2.02e-12 Dental caries; CRC cis rs801193 1.000 rs4717319 chr7:66242593 A/G cg18876405 chr7:65276391 NA 0.59 10.46 0.5 2.73e-22 Aortic root size; CRC cis rs12048904 0.964 rs8888 chr1:101338324 A/G cg00063077 chr1:101360652 SLC30A7;EXTL2 0.51 7.49 0.38 6.56e-13 Multiple sclerosis; CRC cis rs4481887 1.000 rs6681423 chr1:248482834 C/A cg00666640 chr1:248458726 OR2T12 0.55 9.62 0.47 1.79e-19 Common traits (Other); CRC cis rs12148488 0.966 rs12899062 chr15:75347641 A/C cg09165964 chr15:75287851 SCAMP5 -0.5 -7.81 -0.4 7.86e-14 Caffeine consumption; CRC cis rs4332037 0.624 rs11766944 chr7:1888051 G/A cg23378565 chr7:2036160 MAD1L1 -0.4 -6.04 -0.32 4.08e-9 Bipolar disorder; CRC cis rs7552404 0.731 rs1689275 chr1:76409655 T/C cg22875332 chr1:76189707 ACADM -0.47 -5.9 -0.31 9.03e-9 Blood metabolite levels;Acylcarnitine levels; CRC cis rs1218582 0.772 rs1976559 chr1:154879788 A/T cg03351412 chr1:154909251 PMVK 0.54 8.68 0.43 1.92e-16 Prostate cancer; CRC cis rs7089973 0.872 rs17092497 chr10:116612628 G/A cg03647239 chr10:116582469 FAM160B1 0.42 5.82 0.31 1.4e-8 Bipolar disorder or attention deficit hyperactivity disorder; CRC cis rs7772486 0.875 rs9403770 chr6:146423334 C/T cg23711669 chr6:146136114 FBXO30 0.66 11.56 0.54 3.65e-26 Lobe attachment (rater-scored or self-reported); CRC trans rs10983614 1.000 rs7867776 chr9:120072627 A/G cg22654626 chr19:18699620 C19orf60 0.45 6.33 0.33 7.88e-10 Survival in pancreatic cancer; CRC cis rs17401966 1.000 rs7520651 chr1:10329872 G/A cg19773385 chr1:10388646 KIF1B -0.58 -8.2 -0.41 5.58e-15 Hepatocellular carcinoma; CRC cis rs10504229 1.000 rs3814486 chr8:58191226 A/T cg05313129 chr8:58192883 C8orf71 -0.47 -6.99 -0.36 1.49e-11 Developmental language disorder (linguistic errors); CRC cis rs12477438 0.520 rs6542866 chr2:99764592 T/C cg14399236 chr2:99771627 LIPT1;TSGA10 0.73 12.36 0.56 4.4e-29 Chronic sinus infection; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg20067688 chr20:30449097 DUSP15 0.47 6.81 0.35 4.69e-11 Anxiety disorder; CRC cis rs17095355 1.000 rs731793 chr10:111716667 C/G cg00817464 chr10:111662876 XPNPEP1 0.62 8.3 0.42 2.81e-15 Biliary atresia; CRC cis rs6964587 0.626 rs2188841 chr7:91522641 A/G cg17063962 chr7:91808500 NA -0.58 -9.17 -0.45 5.17e-18 Breast cancer; CRC cis rs10751667 0.600 rs6597948 chr11:1005308 C/T ch.11.42038R chr11:967971 AP2A2 0.57 9.04 0.45 1.37e-17 Alzheimer's disease (late onset); CRC trans rs343496 0.941 rs10975412 chr9:6049547 A/G cg24311644 chr8:1654216 DLGAP2 -0.47 -6.06 -0.32 3.81e-9 Asthma and hay fever; CRC cis rs17767392 0.881 rs1859643 chr14:72055468 G/T cg13720639 chr14:72061746 SIPA1L1 -0.55 -7.06 -0.36 1.02e-11 Mitral valve prolapse; CRC cis rs10504229 0.728 rs72650855 chr8:58152570 A/G cg08219700 chr8:58056026 NA 0.45 5.74 0.3 2.11e-8 Developmental language disorder (linguistic errors); CRC trans rs61931739 0.534 rs10506120 chr12:34235603 G/A cg26384229 chr12:38710491 ALG10B 0.54 6.84 0.35 3.8e-11 Morning vs. evening chronotype; CRC cis rs10463316 0.894 rs954341 chr5:150751855 G/A cg03212797 chr5:150827313 SLC36A1 -0.53 -8.35 -0.42 1.95e-15 Metabolite levels (Pyroglutamine); CRC cis rs6940638 0.662 rs7759694 chr6:27240956 C/T cg12292205 chr6:26970375 C6orf41 -0.54 -7.38 -0.38 1.3e-12 Intelligence (multi-trait analysis); CRC cis rs7772486 0.754 rs13214277 chr6:146136125 G/T cg13319975 chr6:146136371 FBXO30 -0.48 -7.15 -0.37 5.65e-12 Lobe attachment (rater-scored or self-reported); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg20368377 chr13:23499360 NA -0.35 -6.25 -0.33 1.27e-9 Liver disease severity in Alagille syndrome; CRC cis rs3768617 0.510 rs2296294 chr1:183095596 T/C ch.1.3577855R chr1:183094577 LAMC1 0.89 15.86 0.66 1.84e-42 Fuchs's corneal dystrophy; CRC cis rs344364 0.511 rs1742467 chr16:1950187 G/T cg09830162 chr16:1889614 FAHD1;C16orf73 -0.77 -9.36 -0.46 1.32e-18 Glomerular filtration rate in chronic kidney disease; CRC cis rs9322193 0.886 rs9322198 chr6:149944908 T/C cg13206674 chr6:150067644 NUP43 0.65 9.76 0.47 6.33e-20 Lung cancer; CRC trans rs561341 0.609 rs4795659 chr17:30187139 C/G cg20587970 chr11:113659929 NA 0.69 8.71 0.43 1.54e-16 Hip circumference adjusted for BMI; CRC cis rs7546094 0.967 rs910697 chr1:113063125 A/G cg22162597 chr1:113214053 CAPZA1 0.41 5.88 0.31 1.03e-8 Platelet distribution width; CRC cis rs8105895 0.935 rs7247228 chr19:22250136 C/T cg02657401 chr19:22469223 NA -0.34 -5.65 -0.3 3.56e-8 Body mass index (change over time); CRC cis rs35110281 0.776 rs229357 chr21:44982717 T/C cg01579765 chr21:45077557 HSF2BP -0.38 -7.26 -0.37 2.76e-12 Mean corpuscular volume; CRC cis rs751837 0.591 rs12100549 chr14:103417030 C/T cg10087771 chr14:103399429 CDC42BPB 0.6 6.18 0.32 1.93e-9 Large B-cell lymphoma; CRC cis rs453193 0.573 rs2630744 chr2:8464827 A/T cg12167548 chr2:8464763 NA -0.37 -6.87 -0.35 3.32e-11 Granulocyte percentage of myeloid white cells; CRC cis rs11711311 1.000 rs2305545 chr3:113499733 A/G cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.52 -7.09 -0.36 8.12e-12 IgG glycosylation; CRC cis rs7772486 0.875 rs1330939 chr6:146308518 T/A cg23711669 chr6:146136114 FBXO30 0.61 10.1 0.49 4.69e-21 Lobe attachment (rater-scored or self-reported); CRC cis rs57221529 0.825 rs72703051 chr5:582997 G/A cg17948913 chr5:572064 NA 0.55 5.85 0.31 1.2e-8 Lung disease severity in cystic fibrosis; CRC cis rs62064224 0.589 rs9910731 chr17:30784034 A/G cg25809561 chr17:30822961 MYO1D 0.57 10.51 0.5 1.87e-22 Schizophrenia; CRC cis rs12188164 0.515 rs11742006 chr5:408529 C/T cg21972741 chr5:435613 AHRR 0.48 6.35 0.33 7.04e-10 Cystic fibrosis severity; CRC cis rs17711722 0.523 rs313812 chr7:65505043 T/C cg02869306 chr7:64672164 INTS4L1 0.45 7.9 0.4 4.36e-14 Calcium levels; CRC cis rs12497850 0.931 rs7621015 chr3:49016056 A/G cg07636037 chr3:49044803 WDR6 1.05 19.14 0.73 2.13e-55 Parkinson's disease; CRC cis rs9379850 0.527 rs9393704 chr6:26358775 T/C cg14345882 chr6:26364793 BTN3A2 0.64 5.63 0.3 3.85e-8 Intelligence (multi-trait analysis); CRC cis rs7264396 0.528 rs3787174 chr20:34487921 G/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.54 -7.96 -0.4 2.83e-14 Total cholesterol levels; CRC cis rs12580194 0.593 rs61957938 chr12:55747266 C/G cg19537932 chr12:55886519 OR6C68 -0.72 -9.1 -0.45 9.11e-18 Cancer; CRC cis rs10046574 0.831 rs77263000 chr7:135099419 C/T cg27474649 chr7:135195673 CNOT4 0.69 5.71 0.3 2.58e-8 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs1790761 0.501 rs4930210 chr11:67404726 G/T cg00290607 chr11:67383545 NA -0.4 -6.63 -0.34 1.35e-10 Mean corpuscular volume; CRC cis rs6912958 0.535 rs242283 chr6:88030931 C/T cg08069147 chr6:88032118 GJB7;C6orf162 0.72 11.6 0.54 2.6e-26 Monocyte percentage of white cells; CRC cis rs7666738 0.800 rs7683737 chr4:99070880 A/T cg17366294 chr4:99064904 C4orf37 0.42 7.12 0.37 6.87e-12 Colonoscopy-negative controls vs population controls; CRC trans rs10983614 1.000 rs7867776 chr9:120072627 A/G cg19386303 chr19:47104863 CALM3 0.46 6.43 0.33 4.52e-10 Survival in pancreatic cancer; CRC cis rs10461617 0.541 rs832575 chr5:56161787 C/T cg24531977 chr5:56204891 C5orf35 -0.64 -6.82 -0.35 4.38e-11 Type 2 diabetes; CRC cis rs597539 0.521 rs7943745 chr11:68605828 A/G cg21963583 chr11:68658836 MRPL21 -0.41 -6.99 -0.36 1.5e-11 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs10206020 0.885 rs6746052 chr2:1576811 T/C cg12573674 chr2:1569213 NA -0.78 -10.53 -0.5 1.54e-22 IgG glycosylation; CRC cis rs2929278 0.617 rs3087657 chr15:44063859 A/G cg02155558 chr15:43621948 ADAL;LCMT2 0.47 6.73 0.35 7.44e-11 Schizophrenia; CRC cis rs11212617 1.000 rs1003623 chr11:108152582 C/T cg12106634 chr11:108092400 ATM;NPAT 0.42 6.12 0.32 2.71e-9 Response to metformin in type 2 diabetes (glycemic); CRC cis rs9916302 0.821 rs412430 chr17:37737094 C/G cg00129232 chr17:37814104 STARD3 -0.55 -7.97 -0.4 2.61e-14 Glomerular filtration rate (creatinine); CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg27216355 chr16:71599010 NA 0.45 6.01 0.31 4.9e-9 Thyroid stimulating hormone; CRC cis rs1552244 0.832 rs66597916 chr3:10195407 T/C cg18598329 chr3:10140678 FANCD2;C3orf24 -0.8 -9.04 -0.45 1.41e-17 Alzheimer's disease; CRC cis rs7727544 0.647 rs72793280 chr5:131562900 C/T cg11843238 chr5:131593191 PDLIM4 0.36 6.53 0.34 2.56e-10 Blood metabolite levels; CRC cis rs2412459 1.000 rs6492925 chr15:40304170 T/G cg20255370 chr15:40268687 EIF2AK4 -0.7 -6.58 -0.34 1.89e-10 Response to haloperidol in psychosis; CRC cis rs9372498 0.536 rs1319988 chr6:118782379 G/A cg22561889 chr6:118971681 C6orf204 0.52 6.7 0.35 9.08e-11 Diastolic blood pressure; CRC cis rs807669 0.903 rs807668 chr22:19162686 A/G cg02655711 chr22:19163373 SLC25A1 0.98 20.38 0.75 2.87e-60 Metabolite levels; CRC cis rs910316 0.591 rs7157158 chr14:75457238 A/G cg03030879 chr14:75389066 RPS6KL1 -0.41 -6.21 -0.32 1.61e-9 Height; CRC cis rs926938 0.563 rs360576 chr1:115459174 A/C cg12756093 chr1:115239321 AMPD1 -0.54 -7.6 -0.39 3.05e-13 Autism; CRC cis rs11098499 0.863 rs7699064 chr4:120428309 A/G cg24375607 chr4:120327624 NA -0.48 -7.17 -0.37 5.07e-12 Corneal astigmatism; CRC cis rs787274 0.850 rs4979176 chr9:115641181 A/G cg13803584 chr9:115635662 SNX30 0.64 6.37 0.33 6.5e-10 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs7772486 0.875 rs6913797 chr6:146413758 A/G cg13319975 chr6:146136371 FBXO30 -0.39 -6.06 -0.32 3.71e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs2153535 0.580 rs6929206 chr6:8447961 A/G cg07606381 chr6:8435919 SLC35B3 0.66 10.65 0.51 6.06e-23 Motion sickness; CRC cis rs7586879 0.520 rs6718511 chr2:25122324 A/G cg04586622 chr2:25135609 ADCY3 -0.55 -10.22 -0.49 1.81e-21 Body mass index; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg22806587 chr15:75871813 PTPN9 0.47 7.85 0.4 5.9e-14 Liver disease severity in Alagille syndrome; CRC cis rs8060686 1.000 rs8060686 chr16:67911517 T/C cg07125278 chr16:67683757 RLTPR -0.5 -6.92 -0.36 2.37e-11 HDL cholesterol;Metabolic syndrome; CRC cis rs787274 0.543 rs1324930 chr9:115634639 A/G cg13803584 chr9:115635662 SNX30 0.68 7.07 0.36 9.15e-12 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs10504229 1.000 rs949848 chr8:58169125 A/G cg01721255 chr8:58191610 C8orf71 0.46 5.88 0.31 1e-8 Developmental language disorder (linguistic errors); CRC cis rs368123 0.686 rs2774226 chr6:160700386 G/A cg19643109 chr6:160697625 NA -0.34 -6.27 -0.33 1.17e-9 Waist circumference; CRC cis rs4563143 0.647 rs73029014 chr19:29257655 G/C cg12756686 chr19:29218302 NA 0.6 8.99 0.44 2.04e-17 Methadone dose in opioid dependence; CRC cis rs10504229 0.953 rs114853497 chr8:58176176 A/T cg24829409 chr8:58192753 C8orf71 -0.68 -11.34 -0.53 2.27e-25 Developmental language disorder (linguistic errors); CRC cis rs8180040 0.966 rs11914795 chr3:47557722 G/A cg10298567 chr3:47292165 KIF9 -0.36 -5.83 -0.31 1.3e-8 Colorectal cancer; CRC cis rs13108904 0.870 rs4974577 chr4:1266046 G/A cg21620606 chr4:1342894 KIAA1530 0.38 6.4 0.33 5.46e-10 Obesity-related traits; CRC cis rs6964587 0.839 rs9656002 chr7:91475007 A/G cg17063962 chr7:91808500 NA -0.71 -11.2 -0.53 7.05e-25 Breast cancer; CRC trans rs4263408 0.934 rs9683743 chr4:39703194 A/C cg03704503 chr10:76994576 COMTD1 -0.41 -6.2 -0.32 1.72e-9 Plasma amyloid beta peptide concentrations (ABx-40); CRC cis rs17376456 0.877 rs10213956 chr5:93460839 C/T cg21475434 chr5:93447410 FAM172A 0.74 7.63 0.39 2.51e-13 Diabetic retinopathy; CRC cis rs11809207 0.523 rs12565756 chr1:26498196 G/T cg00147160 chr1:26503991 CNKSR1 0.31 6.15 0.32 2.21e-9 Height; CRC cis rs11123170 0.529 rs1015755 chr2:113968307 G/A cg21482265 chr2:113992762 PAX8;LOC440839;LOC654433 0.53 6.27 0.33 1.15e-9 Renal function-related traits (BUN); CRC trans rs1493916 0.777 rs1845385 chr18:31318336 T/C cg27147174 chr7:100797783 AP1S1 -0.39 -6.65 -0.34 1.19e-10 Life satisfaction; CRC cis rs798554 0.591 rs1182156 chr7:2901084 G/T cg13628971 chr7:2884303 GNA12 0.41 6.15 0.32 2.23e-9 Height; CRC cis rs34172651 0.876 rs2547033 chr16:24743657 C/T cg06505273 chr16:24850292 NA 0.39 6.05 0.32 3.9e-9 Intelligence (multi-trait analysis); CRC cis rs4665809 0.590 rs35615763 chr2:26468778 C/G cg26119090 chr2:26468346 HADHA;HADHB 1.06 15.5 0.65 4.69e-41 Gut microbiome composition (summer); CRC cis rs10504229 1.000 rs115548028 chr8:58170672 T/C cg22535103 chr8:58192502 C8orf71 -0.82 -12.27 -0.56 9.63e-29 Developmental language disorder (linguistic errors); CRC trans rs7726839 0.540 rs72703078 chr5:594987 A/C cg25482853 chr8:67687455 SGK3 1.09 12.84 0.58 7.36e-31 Obesity-related traits; CRC cis rs919433 1.000 rs2889363 chr2:198163699 A/G cg10820045 chr2:198174542 NA -0.54 -10.61 -0.5 8.11e-23 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC cis rs7224685 0.520 rs12453690 chr17:4037678 T/C cg09597638 chr17:3907349 NA -0.64 -10.99 -0.52 3.95e-24 Type 2 diabetes; CRC cis rs7894051 1.000 rs11101723 chr10:135192139 C/A cg20534287 chr10:135191450 PAOX 0.77 5.85 0.31 1.21e-8 Lifespan; CRC cis rs739401 0.595 rs2237903 chr11:2967901 C/T cg05729581 chr11:3078854 CARS -0.53 -7.54 -0.38 4.54e-13 Longevity; CRC cis rs2243480 1.000 rs35421653 chr7:65363429 C/A cg18252515 chr7:66147081 NA -1.12 -12.85 -0.58 6.69e-31 Diabetic kidney disease; CRC cis rs1448094 0.511 rs10863080 chr12:86153149 C/T cg00310523 chr12:86230176 RASSF9 -0.38 -6.09 -0.32 3.19e-9 Major depressive disorder; CRC cis rs514406 0.668 rs1672911 chr1:53340320 T/C cg27535305 chr1:53392650 SCP2 -0.43 -7.61 -0.39 2.86e-13 Monocyte count; CRC cis rs6570726 0.791 rs447992 chr6:145817184 C/T cg05347473 chr6:146136440 FBXO30 0.4 6.23 0.32 1.45e-9 Lobe attachment (rater-scored or self-reported); CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg03270197 chr6:166796579 BRP44L 0.49 6.62 0.34 1.42e-10 Thyroid stimulating hormone; CRC trans rs6678914 1.000 rs2167588 chr1:202190369 C/T cg19977628 chr5:1262072 TERT 0.4 5.96 0.31 6.34e-9 Breast cancer (estrogen-receptor negative);Breast cancer; CRC cis rs2228479 0.850 rs17226666 chr16:89835401 G/A cg06558623 chr16:89946397 TCF25 1.13 10.49 0.5 2.06e-22 Skin colour saturation; CRC cis rs7666738 0.830 rs11727612 chr4:99001662 T/C cg17366294 chr4:99064904 C4orf37 0.44 7.39 0.38 1.19e-12 Colonoscopy-negative controls vs population controls; CRC cis rs9467160 1.000 rs10946700 chr6:24442158 G/T cg16211469 chr6:24423932 MRS2 0.35 5.67 0.3 3.06e-8 Liver enzyme levels; CRC cis rs6088580 0.608 rs2105109 chr20:32971932 A/G cg24642439 chr20:33292090 TP53INP2 -0.38 -6.41 -0.33 5.08e-10 Glomerular filtration rate (creatinine); CRC cis rs863345 0.604 rs10797013 chr1:158465506 G/C cg12129480 chr1:158549410 OR10X1 -0.29 -6.11 -0.32 2.86e-9 Pneumococcal bacteremia; CRC cis rs11212617 0.837 rs4754298 chr11:108023284 G/A cg12106634 chr11:108092400 ATM;NPAT 0.44 6.57 0.34 1.94e-10 Response to metformin in type 2 diabetes (glycemic); CRC cis rs6504622 1.000 rs4968286 chr17:45017645 T/C cg16759221 chr17:45003025 GOSR2 0.45 6.92 0.36 2.37e-11 Orofacial clefts; CRC cis rs2559856 0.967 rs2695297 chr12:102082218 T/C cg12924262 chr12:102091054 CHPT1 0.56 8.4 0.42 1.33e-15 Blood protein levels; CRC cis rs10504229 0.906 rs7842482 chr8:58167720 A/T cg24829409 chr8:58192753 C8orf71 -0.58 -10.3 -0.49 9.65e-22 Developmental language disorder (linguistic errors); CRC cis rs7945705 0.837 rs2742474 chr11:9002089 A/G cg21881798 chr11:8931708 C11orf17;ST5 -0.68 -11.35 -0.53 2.04e-25 Hemoglobin concentration; CRC cis rs6951245 0.748 rs79658522 chr7:1095877 A/G cg26224354 chr7:1096374 C7orf50;GPR146 -0.93 -12.11 -0.56 3.59e-28 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs11864453 0.749 rs7192730 chr16:72124219 T/C cg01557791 chr16:72042693 DHODH -0.44 -6.14 -0.32 2.36e-9 Fibrinogen levels; CRC cis rs1801251 0.896 rs2197563 chr2:233687080 G/A cg25237894 chr2:233734115 C2orf82 -0.41 -6.68 -0.35 1.01e-10 Coronary artery disease; CRC cis rs7493 0.755 rs17166859 chr7:94995519 T/C cg04155289 chr7:94953770 PON1 -0.56 -7.02 -0.36 1.27e-11 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs2836974 0.568 rs377098 chr21:40535216 G/A cg11644478 chr21:40555479 PSMG1 -0.72 -12.17 -0.56 2.17e-28 Cognitive function; CRC cis rs736408 0.924 rs2535629 chr3:52833219 C/T cg18404041 chr3:52824283 ITIH1 -0.44 -8.98 -0.44 2.16e-17 Bipolar disorder; CRC cis rs9325144 0.602 rs11169100 chr12:39077861 G/T cg26384229 chr12:38710491 ALG10B -0.53 -7.37 -0.38 1.35e-12 Morning vs. evening chronotype; CRC cis rs6951245 0.935 rs61910751 chr7:1097895 A/G cg04025307 chr7:1156635 C7orf50 0.64 6.81 0.35 4.53e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC trans rs66573146 0.831 rs56081162 chr4:6989718 C/T cg07817883 chr1:32538562 TMEM39B 1.33 12.33 0.56 5.8e-29 Granulocyte percentage of myeloid white cells; CRC trans rs1814175 0.645 rs1721997 chr11:49916653 T/C cg03929089 chr4:120376271 NA -0.91 -16.07 -0.66 2.65e-43 Height; CRC cis rs4713118 0.662 rs149900 chr6:28014597 C/T cg18032046 chr6:28092343 ZSCAN16 -0.47 -5.87 -0.31 1.07e-8 Parkinson's disease; CRC cis rs2760061 0.819 rs708120 chr1:228207651 G/C cg18477163 chr1:228402036 OBSCN 0.42 7.04 0.36 1.13e-11 Diastolic blood pressure; CRC cis rs7772486 0.875 rs7766463 chr6:146364453 A/G cg05347473 chr6:146136440 FBXO30 0.37 5.89 0.31 9.38e-9 Lobe attachment (rater-scored or self-reported); CRC trans rs1728785 1.000 rs12918861 chr16:68566508 G/A cg04657470 chr2:198365150 HSPE1;HSPD1 0.57 6.77 0.35 6.09e-11 Ulcerative colitis; CRC cis rs7781266 0.790 rs1364503 chr7:133083504 T/C cg03336402 chr7:133662267 EXOC4 -0.48 -5.81 -0.31 1.46e-8 Educational attainment (college completion); CRC cis rs728616 0.614 rs55720611 chr10:81790299 G/A cg05935833 chr10:81318306 SFTPA2 -0.52 -6.97 -0.36 1.71e-11 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs9322193 0.962 rs17673294 chr6:150134993 G/A cg05861140 chr6:150128134 PCMT1 -0.45 -7.19 -0.37 4.36e-12 Lung cancer; CRC cis rs9372498 0.536 rs9489467 chr6:118935206 C/T cg01339444 chr6:118972232 C6orf204 0.54 6.01 0.31 4.89e-9 Diastolic blood pressure; CRC trans rs72956618 1.000 rs68160031 chr2:207489365 T/G cg16073378 chr2:468413 NA -0.65 -6.35 -0.33 7.35e-10 Tonsillectomy; CRC cis rs1707322 1.000 rs1613296 chr1:46546852 A/C cg03146154 chr1:46216737 IPP -0.45 -6.07 -0.32 3.52e-9 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs875971 0.545 rs10950027 chr7:65634151 C/T cg11764359 chr7:65958608 NA 0.47 5.98 0.31 5.82e-9 Aortic root size; CRC cis rs17711722 0.522 rs4642526 chr7:65216742 G/T cg00343986 chr7:65444356 GUSB 0.48 6.93 0.36 2.27e-11 Calcium levels; CRC cis rs7677751 0.806 rs6850748 chr4:55099164 T/G cg17187183 chr4:55093834 PDGFRA 0.51 7.27 0.37 2.72e-12 Corneal astigmatism; CRC cis rs4819052 0.851 rs1999333 chr21:46670401 C/G cg02159808 chr21:46707872 POFUT2;LOC642852 0.49 6.44 0.33 4.15e-10 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs9660180 0.783 rs1107910 chr1:1692321 C/T cg23982607 chr1:1823379 GNB1 -0.6 -9.58 -0.47 2.45e-19 Body mass index; CRC cis rs3790455 0.560 rs1171557 chr1:156451264 C/T cg14087168 chr1:156450669 MEF2D -0.37 -6.03 -0.32 4.45e-9 Migraine; CRC cis rs172166 0.637 rs1225592 chr6:28150242 G/A cg10876282 chr6:28092338 ZSCAN16 0.48 6.6 0.34 1.68e-10 Cardiac Troponin-T levels; CRC cis rs7809950 1.000 rs2237676 chr7:107198079 C/A cg23024343 chr7:107201750 COG5 -0.61 -8.56 -0.43 4.51e-16 Coronary artery disease; CRC cis rs60871478 1.000 rs62432253 chr7:802928 A/G cg05535760 chr7:792225 HEATR2 0.97 12.29 0.56 8.01e-29 Cerebrospinal P-tau181p levels; CRC cis rs7618915 0.532 rs13060675 chr3:52674300 T/G cg07507251 chr3:52567010 NT5DC2 0.42 6.04 0.32 4.11e-9 Bipolar disorder; CRC cis rs7833986 0.501 rs72651502 chr8:56875533 A/G cg23139584 chr8:56987506 RPS20;SNORD54 0.77 9.83 0.48 3.7e-20 Height; CRC cis rs7811142 0.830 rs7792525 chr7:99972122 A/G cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.73 10.01 0.48 9.17e-21 Platelet count; CRC cis rs1577917 1.000 rs36096931 chr6:86693134 T/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.52 -6.8 -0.35 5.06e-11 Response to antipsychotic treatment; CRC cis rs589448 0.902 rs315134 chr12:69762713 G/A cg20891283 chr12:69753455 YEATS4 0.98 21.22 0.76 1.46e-63 Cerebrospinal fluid biomarker levels; CRC cis rs78545713 0.536 rs2179516 chr6:26229411 C/T cg01420254 chr6:26195488 NA 0.66 5.85 0.31 1.21e-8 Iron status biomarkers (total iron binding capacity); CRC cis rs10971721 0.822 rs72725376 chr9:33841929 A/G cg13495928 chr9:33750294 PRSS3 0.55 5.9 0.31 9.17e-9 Body mass index; CRC cis rs1552244 0.752 rs9867091 chr3:10043429 T/C cg10729496 chr3:10149963 C3orf24 0.46 6.16 0.32 2.12e-9 Alzheimer's disease; CRC cis rs11168351 1.000 rs11168351 chr12:48403765 C/T cg00601486 chr12:48723148 H1FNT 0.35 6.6 0.34 1.61e-10 Bipolar disorder and schizophrenia; CRC cis rs9341808 0.718 rs7740627 chr6:80916347 A/G cg08355045 chr6:80787529 NA 0.43 6.9 0.36 2.73e-11 Sitting height ratio; CRC cis rs3087591 0.960 rs2905790 chr17:29476110 A/G cg24425628 chr17:29625626 OMG;NF1 0.86 15.73 0.66 5.58e-42 Hip circumference; CRC cis rs2976388 0.573 rs1529865 chr8:143789171 C/T cg20041105 chr8:143859282 LYNX1 0.44 7.93 0.4 3.35e-14 Urinary tract infection frequency; CRC trans rs8012941 0.593 rs4902190 chr14:63314591 A/G cg24626003 chr11:6502573 ARFIP2;FXC1 0.38 5.98 0.31 5.94e-9 Major depressive disorder; CRC cis rs870825 0.860 rs72703521 chr4:185603080 T/C cg04058563 chr4:185651563 MLF1IP 0.56 5.87 0.31 1.04e-8 Blood protein levels; CRC cis rs6840360 0.607 rs6815320 chr4:152432500 T/C cg09659197 chr4:152720779 NA 0.33 6.66 0.34 1.14e-10 Intelligence (multi-trait analysis); CRC cis rs3617 0.625 rs56019197 chr3:52874753 T/C cg07507251 chr3:52567010 NT5DC2 -0.4 -6.22 -0.32 1.51e-9 Red blood cell count;Autism spectrum disorder or schizophrenia; CRC trans rs11581859 0.950 rs7555367 chr1:99374045 T/G cg12183875 chr3:169587454 LRRC31 0.28 6.54 0.34 2.41e-10 Response to cognitive-behavioural therapy in anxiety disorder; CRC cis rs1105228 0.808 rs557386 chr6:165716293 T/C cg20535254 chr6:165714960 C6orf118 -0.28 -5.79 -0.3 1.62e-8 Number of pregnancies;Number of children; CRC cis rs6121246 0.909 rs6060821 chr20:30294034 C/T cg13852791 chr20:30311386 BCL2L1 0.73 11.69 0.54 1.25e-26 Mean corpuscular hemoglobin; CRC cis rs5769765 0.773 rs9616206 chr22:50310847 G/T cg26441486 chr22:50317300 CRELD2 0.33 5.65 0.3 3.42e-8 Schizophrenia; CRC cis rs9640161 0.663 rs1916932 chr7:150021644 T/C cg12556325 chr7:150026731 C7orf29;LRRC61 -0.39 -5.93 -0.31 7.47e-9 Blood protein levels;Circulating chemerin levels; CRC cis rs7909074 0.966 rs4268464 chr10:45401081 T/A cg04218760 chr10:45406644 TMEM72 -0.34 -9.21 -0.45 3.85e-18 Mean corpuscular volume; CRC cis rs3750965 0.959 rs3168115 chr11:68858090 A/T cg06818126 chr11:68850279 TPCN2 0.48 6.91 0.36 2.57e-11 Hair color; CRC cis rs1707322 0.927 rs11211194 chr1:46282084 C/T cg06784218 chr1:46089804 CCDC17 0.5 8.72 0.43 1.44e-16 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs1018836 0.847 rs35409073 chr8:91648036 G/T cg16814680 chr8:91681699 NA -0.75 -11.76 -0.54 6.87e-27 Ejection fraction in Tripanosoma cruzi seropositivity; CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg06908895 chr20:25038786 ACSS1 -0.63 -7.64 -0.39 2.41e-13 Diisocyanate-induced asthma; CRC cis rs738322 1.000 rs4379 chr22:38569171 T/C cg25457927 chr22:38595422 NA -0.36 -7.47 -0.38 7.23e-13 Cutaneous nevi; CRC cis rs6740322 0.748 rs6720087 chr2:43468745 A/G cg06169590 chr2:43455088 ZFP36L2;LOC100129726 0.73 9.17 0.45 5.12e-18 Coronary artery disease; CRC cis rs853679 0.882 rs3757188 chr6:28107357 T/C cg06470822 chr6:28175283 NA 0.81 6.57 0.34 2.03e-10 Depression; CRC cis rs11105306 1 rs11105306 chr12:89897388 C/T cg08166232 chr12:89918718 WDR51B;GALNT4 -0.61 -7.94 -0.4 3.25e-14 NT-proBNP levels in acute coronary syndrome; CRC cis rs6502050 0.835 rs9900128 chr17:80087920 A/T cg02741985 chr17:80059408 CCDC57 0.43 7.13 0.37 6.48e-12 Life satisfaction; CRC cis rs7172809 0.643 rs11855272 chr15:77840790 G/A cg10437265 chr15:77819839 NA -0.35 -5.7 -0.3 2.62e-8 Glucose homeostasis traits; CRC cis rs9611565 0.765 rs132909 chr22:41802031 G/A cg03806693 chr22:41940476 POLR3H 0.98 12.32 0.56 6.13e-29 Vitiligo; CRC cis rs2806561 1.000 rs2746553 chr1:23493246 T/C cg19743168 chr1:23544995 NA 0.38 6.02 0.31 4.77e-9 Height; CRC cis rs8180040 1.000 rs807810 chr3:47403892 G/A cg02527881 chr3:46936655 PTH1R 0.4 7.66 0.39 2.15e-13 Colorectal cancer; CRC trans rs3733585 0.648 rs7378305 chr4:9954893 C/T cg26043149 chr18:55253948 FECH -0.5 -7.72 -0.39 1.39e-13 Cleft plate (environmental tobacco smoke interaction); CRC cis rs9814567 1.000 rs11928499 chr3:134232350 A/G cg06541857 chr3:134203789 ANAPC13;CEP63 0.39 5.74 0.3 2.16e-8 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs9747201 1.000 rs58472289 chr17:80111895 G/T cg14673194 chr17:80132900 CCDC57 0.49 6.35 0.33 7.1e-10 Peripheral arterial disease (traffic-related air pollution interaction); CRC trans rs13046373 0.905 rs4816372 chr21:32077414 A/T cg03179478 chr3:150264694 SERP1;EIF2A -0.41 -6.0 -0.31 5.14e-9 HDL cholesterol; CRC cis rs5769765 1.000 rs1033665 chr22:50252127 A/G cg22709217 chr22:50311962 ALG12;CRELD2 -0.93 -15.1 -0.64 1.72e-39 Schizophrenia; CRC cis rs9487051 0.676 rs1608042 chr6:109595631 G/A cg21918786 chr6:109611834 NA -0.41 -7.17 -0.37 4.84e-12 Reticulocyte fraction of red cells; CRC cis rs1158570 0.500 rs2670890 chr8:131314923 G/A cg21674704 chr8:131455249 NA 0.44 6.58 0.34 1.9e-10 Platelet count; CRC cis rs4969178 0.930 rs12452576 chr17:76386037 A/C cg05887092 chr17:76393375 PGS1 0.54 9.88 0.48 2.54e-20 HDL cholesterol levels; CRC cis rs2857891 0.909 rs17191140 chr11:6944283 G/A cg26870460 chr11:6947759 ZNF215 0.59 6.06 0.32 3.68e-9 Response to cytadine analogues (cytosine arabinoside); CRC cis rs7312933 0.669 rs7974476 chr12:42542484 C/A cg19980929 chr12:42632907 YAF2 0.44 6.64 0.34 1.32e-10 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CRC cis rs3733585 0.699 rs11724510 chr4:9958583 C/T cg00071950 chr4:10020882 SLC2A9 -0.55 -9.92 -0.48 1.83e-20 Cleft plate (environmental tobacco smoke interaction); CRC cis rs7503807 0.515 rs12946206 chr17:78687270 G/T cg00549398 chr17:78725201 RPTOR 0.43 5.77 0.3 1.87e-8 Obesity; CRC cis rs10924970 0.805 rs2789363 chr1:235519034 A/T cg26050004 chr1:235667680 B3GALNT2 0.44 6.32 0.33 8.62e-10 Asthma; CRC cis rs2404602 0.608 rs17361504 chr15:76601871 A/G cg00316803 chr15:76480434 C15orf27 -0.4 -7.19 -0.37 4.45e-12 Blood metabolite levels; CRC cis rs9372498 0.536 rs9489450 chr6:118904385 G/A cg15382696 chr6:118971807 C6orf204 0.61 7.77 0.39 1.01e-13 Diastolic blood pressure; CRC cis rs3820068 0.581 rs74054797 chr1:15926217 G/A cg27534772 chr1:16042836 PLEKHM2 0.54 10.49 0.5 2.13e-22 Systolic blood pressure; CRC cis rs6461049 0.765 rs4719431 chr7:2140312 T/C cg04267008 chr7:1944627 MAD1L1 -0.52 -7.49 -0.38 6.57e-13 Schizophrenia; CRC cis rs2404602 0.716 rs67920045 chr15:76800084 G/A cg03037974 chr15:76606532 NA 0.66 10.91 0.52 7.2e-24 Blood metabolite levels; CRC cis rs8177253 1.000 rs8177272 chr3:133482870 C/T cg11941060 chr3:133502564 NA -0.57 -9.88 -0.48 2.42e-20 Iron status biomarkers; CRC cis rs9868809 0.505 rs13434258 chr3:48738491 T/C cg07636037 chr3:49044803 WDR6 -0.68 -6.53 -0.34 2.57e-10 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; CRC cis rs7524258 0.868 rs1304711 chr1:7270320 G/T cg07173049 chr1:7289937 CAMTA1 -0.52 -8.6 -0.43 3.34e-16 Tourette's syndrome or obsessive-compulsive disorder; CRC cis rs4713118 0.662 rs469228 chr6:27970704 A/G cg03623178 chr6:28175578 NA 0.83 12.47 0.57 1.76e-29 Parkinson's disease; CRC cis rs524281 0.814 rs2270448 chr11:65835931 G/T cg16950941 chr11:66035639 RAB1B -0.58 -7.33 -0.37 1.84e-12 Electroencephalogram traits; CRC cis rs12826942 0.879 rs7312066 chr12:42766380 G/C cg11827402 chr12:42719852 PPHLN1;ZCRB1 0.61 7.39 0.38 1.26e-12 Coronary artery disease; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg07000785 chr1:68150823 GADD45A 0.44 6.12 0.32 2.69e-9 Response to antipsychotic treatment; CRC cis rs10540 1.000 rs79808876 chr11:465763 C/A cg11503833 chr11:492997 NA 0.57 5.95 0.31 6.75e-9 Body mass index; CRC cis rs7666738 0.830 rs17484890 chr4:99013778 T/C cg05340658 chr4:99064831 C4orf37 0.59 9.04 0.45 1.36e-17 Colonoscopy-negative controls vs population controls; CRC cis rs7666738 0.830 rs6852015 chr4:99054373 C/A cg17366294 chr4:99064904 C4orf37 0.45 7.71 0.39 1.46e-13 Colonoscopy-negative controls vs population controls; CRC cis rs6541297 0.941 rs6541294 chr1:230278826 A/G cg05784532 chr1:230284198 GALNT2 0.44 6.19 0.32 1.75e-9 Coronary artery disease; CRC cis rs7843479 0.582 rs11135743 chr8:21803008 A/G cg17168535 chr8:21777572 XPO7 0.6 10.04 0.48 7.2e-21 Mean corpuscular volume; CRC cis rs9393777 0.513 rs7754159 chr6:26620312 G/A cg12292205 chr6:26970375 C6orf41 -0.6 -6.73 -0.35 7.52e-11 Intelligence (multi-trait analysis); CRC cis rs12024301 0.557 rs16861453 chr1:183646538 C/G cg11505048 chr1:183622726 RGL1;APOBEC4 0.73 6.43 0.33 4.43e-10 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs8013055 0.796 rs4075104 chr14:106000214 C/A cg23356831 chr14:105996513 TMEM121 0.45 7.48 0.38 7.04e-13 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis); CRC cis rs4718428 0.705 rs3800817 chr7:66263550 T/A cg12165864 chr7:66369176 NA -0.44 -6.08 -0.32 3.25e-9 Corneal structure; CRC cis rs10512697 1.000 rs17637034 chr5:3566549 T/C cg19473799 chr5:3511975 NA -0.78 -5.94 -0.31 7.27e-9 Immune response to smallpox vaccine (IL-6); CRC cis rs2576037 0.583 rs892586 chr18:44560429 C/A cg07416455 chr18:44543612 TCEB3CL;KATNAL2 0.6 8.93 0.44 3.09e-17 Personality dimensions; CRC cis rs1552244 0.572 rs73117481 chr3:10160132 C/T cg18598329 chr3:10140678 FANCD2;C3orf24 -0.91 -10.81 -0.51 1.62e-23 Alzheimer's disease; CRC cis rs7532866 0.885 rs7552065 chr1:26731951 G/T cg17456097 chr1:26900765 RPS6KA1 -0.4 -6.01 -0.31 5.04e-9 Height; CRC cis rs7246657 0.943 rs7255996 chr19:37971699 G/A cg23950597 chr19:37808831 NA -0.49 -6.06 -0.32 3.8e-9 Coronary artery calcification; CRC cis rs875971 0.545 rs313830 chr7:65551931 T/C cg18876405 chr7:65276391 NA -0.45 -6.05 -0.32 4e-9 Aortic root size; CRC cis rs10208940 0.920 rs13400155 chr2:68723636 G/A cg12452813 chr2:68675892 NA 0.51 6.35 0.33 7.33e-10 Urate levels in lean individuals; CRC cis rs9549367 0.737 rs9549712 chr13:113902355 G/A cg00898013 chr13:113819073 PROZ -0.46 -6.51 -0.34 2.77e-10 Platelet distribution width; CRC cis rs10751667 0.621 rs7396107 chr11:970029 C/T cg23136738 chr11:925521 AP2A2 -0.42 -7.09 -0.36 8.19e-12 Alzheimer's disease (late onset); CRC cis rs2710642 0.962 rs7567923 chr2:63085848 C/T cg17519650 chr2:63277830 OTX1 -0.44 -6.39 -0.33 5.82e-10 LDL cholesterol levels;LDL cholesterol; CRC cis rs7072216 0.763 rs6584198 chr10:100169906 G/C cg26618903 chr10:100175079 PYROXD2 -0.55 -9.16 -0.45 5.81e-18 Metabolite levels; CRC cis rs11191205 0.686 rs11191092 chr10:103449251 T/C cg15320455 chr10:103880129 LDB1 0.57 6.26 0.33 1.18e-9 Intelligence (multi-trait analysis); CRC cis rs3733585 0.664 rs17245436 chr4:9958169 A/G cg00071950 chr4:10020882 SLC2A9 -0.54 -9.58 -0.47 2.54e-19 Cleft plate (environmental tobacco smoke interaction); CRC cis rs61160187 0.582 rs58646987 chr5:60275694 C/T cg16298547 chr5:60138761 ELOVL7 -0.27 -5.73 -0.3 2.26e-8 Educational attainment (years of education);Educational attainment (college completion); CRC cis rs921968 0.565 rs6436086 chr2:219640125 T/C cg02176678 chr2:219576539 TTLL4 -0.4 -6.52 -0.34 2.67e-10 Mean corpuscular hemoglobin concentration; CRC cis rs875971 0.792 rs6971752 chr7:65737986 G/A cg18876405 chr7:65276391 NA -0.5 -8.2 -0.41 5.45e-15 Aortic root size; CRC cis rs7677751 0.767 rs6831380 chr4:55076345 G/A cg17187183 chr4:55093834 PDGFRA 0.49 7.03 0.36 1.19e-11 Corneal astigmatism; CRC cis rs8077889 0.917 rs72836547 chr17:41902799 G/T cg16892393 chr17:41919603 NA 0.6 8.64 0.43 2.54e-16 Triglycerides; CRC cis rs947211 1.000 rs823144 chr1:205744546 C/A cg26354017 chr1:205819088 PM20D1 0.43 5.96 0.31 6.41e-9 Parkinson's disease; CRC trans rs7267979 0.966 rs2261784 chr20:25262396 G/C cg17903999 chr18:56338584 MALT1 -0.4 -6.69 -0.35 9.69e-11 Liver enzyme levels (alkaline phosphatase); CRC cis rs4713118 0.629 rs203888 chr6:28021589 C/T cg21251018 chr6:28226885 NKAPL 0.42 6.2 0.32 1.74e-9 Parkinson's disease; CRC cis rs116095464 0.558 rs59113266 chr5:279965 T/C cg22496380 chr5:211416 CCDC127 -0.89 -10.1 -0.49 4.58e-21 Breast cancer; CRC cis rs8114671 0.562 rs6088647 chr20:33505997 T/C cg07148914 chr20:33460835 GGT7 0.44 7.06 0.36 9.84e-12 Height; CRC cis rs72781680 0.752 rs56152044 chr2:23927680 A/G cg08917208 chr2:24149416 ATAD2B 0.97 8.87 0.44 4.8e-17 Lymphocyte counts; CRC trans rs35110281 0.805 rs2838319 chr21:44991901 A/G cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.45 7.47 0.38 7.34e-13 Mean corpuscular volume; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg07522440 chr7:143317300 FAM115C -0.4 -5.97 -0.31 6.05e-9 Myopia (pathological); CRC cis rs6495122 0.501 rs6495144 chr15:75343438 T/C cg14664628 chr15:75095509 CSK 0.46 6.69 0.35 9.73e-11 Caffeine consumption;Diastolic blood pressure;Coffee consumption; CRC cis rs8062405 0.755 rs62034325 chr16:28538640 A/G cg05139728 chr16:28306816 SBK1 -0.36 -5.87 -0.31 1.08e-8 Cognitive ability (multi-trait analysis);Cognitive ability; CRC cis rs58688157 0.705 rs936469 chr11:606749 G/A cg02461776 chr11:598696 PHRF1 0.46 5.85 0.31 1.17e-8 Systemic lupus erythematosus; CRC cis rs7605827 0.930 rs10184585 chr2:15683091 G/A cg19274914 chr2:15703543 NA 0.39 5.82 0.31 1.4e-8 Educational attainment (years of education); CRC cis rs10752881 1.000 rs4454510 chr1:182982303 A/G ch.1.3577855R chr1:183094577 LAMC1 -0.86 -15.33 -0.65 2.04e-40 Colorectal cancer; CRC cis rs8180040 0.966 rs3816779 chr3:47543389 C/T cg02527881 chr3:46936655 PTH1R -0.41 -7.91 -0.4 3.87e-14 Colorectal cancer; CRC cis rs1348850 0.914 rs4893950 chr2:178304885 T/C cg22681709 chr2:178499509 PDE11A -0.4 -7.33 -0.37 1.76e-12 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs6662572 0.686 rs113117837 chr1:46278158 G/A cg08644498 chr1:46502608 NA 0.44 6.85 0.35 3.61e-11 Blood protein levels; CRC cis rs2762353 0.524 rs3923 chr6:25783315 T/C cg17691542 chr6:26056736 HIST1H1C -0.48 -6.73 -0.35 7.55e-11 Blood metabolite levels; CRC cis rs780096 0.506 rs780100 chr2:27652153 G/T cg22903471 chr2:27725779 GCKR -0.36 -5.8 -0.3 1.53e-8 Total body bone mineral density; CRC cis rs17095355 1.000 rs17126886 chr10:111695257 G/C cg00817464 chr10:111662876 XPNPEP1 -0.6 -7.9 -0.4 4.13e-14 Biliary atresia; CRC cis rs6921919 0.583 rs6908137 chr6:28370393 A/C cg21251018 chr6:28226885 NKAPL 0.39 5.75 0.3 2e-8 Autism spectrum disorder or schizophrenia; CRC cis rs6499188 0.522 rs8046299 chr16:68672346 G/A cg02972257 chr16:68554789 NA -0.49 -6.45 -0.33 4.07e-10 Ulcerative colitis; CRC cis rs7918232 0.830 rs7915902 chr10:27410734 T/C cg14240646 chr10:27532245 ACBD5 -0.85 -9.81 -0.48 4.13e-20 Breast cancer; CRC cis rs262150 0.851 rs2527224 chr7:158769198 G/A cg19418458 chr7:158789849 NA -0.45 -7.52 -0.38 5.33e-13 Facial morphology (factor 20); CRC cis rs12681287 0.640 rs7816275 chr8:87373404 A/G cg27223183 chr8:87520930 FAM82B 0.53 7.19 0.37 4.51e-12 Caudate activity during reward; CRC cis rs951366 0.903 rs823116 chr1:205720483 G/A cg26354017 chr1:205819088 PM20D1 0.47 7.07 0.36 9.44e-12 Menarche (age at onset); CRC cis rs7811142 0.830 rs73401443 chr7:99977582 T/G cg00814883 chr7:100076585 TSC22D4 -0.68 -8.65 -0.43 2.29e-16 Platelet count; CRC cis rs6700896 0.832 rs11208693 chr1:66108063 C/T cg04111102 chr1:66153794 NA 0.32 5.66 0.3 3.22e-8 C-reactive protein;Mean corpuscular volume;Mean corpuscular hemoglobin; CRC trans rs7618501 0.699 rs9821675 chr3:49902544 A/G cg21659725 chr3:3221576 CRBN 0.68 10.78 0.51 2.0500000000000001e-23 Intelligence (multi-trait analysis); CRC cis rs12476592 0.602 rs10865340 chr2:63824049 C/G cg10828910 chr2:63850056 LOC388955 0.48 5.86 0.31 1.15e-8 Childhood ear infection; CRC cis rs2180341 1.000 rs9321073 chr6:127609691 C/T cg24812749 chr6:127587940 RNF146 0.94 13.67 0.6 5.36e-34 Breast cancer; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg01338834 chr21:40720919 HMGN1 0.43 6.34 0.33 7.44e-10 Intelligence (multi-trait analysis); CRC cis rs6570726 0.902 rs373321 chr6:145854150 T/A cg05347473 chr6:146136440 FBXO30 0.38 6.06 0.32 3.79e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs911555 0.723 rs6575982 chr14:103862681 G/A cg12935359 chr14:103987150 CKB 0.55 8.72 0.43 1.43e-16 Intelligence (multi-trait analysis); CRC cis rs7412746 0.634 rs7521592 chr1:150821691 A/C cg17724175 chr1:150552817 MCL1 0.51 7.51 0.38 5.78e-13 Melanoma; CRC cis rs9992667 0.868 rs113071828 chr4:38665818 G/A cg19726192 chr4:38663646 FLJ13197 -0.71 -9.0 -0.44 1.81e-17 Eosinophil percentage of granulocytes; CRC cis rs2979489 0.891 rs2915594 chr8:30401367 T/C cg26383811 chr8:30366931 RBPMS -0.69 -10.15 -0.49 3.19e-21 Mean corpuscular hemoglobin;Plateletcrit;Neutrophil count;Granulocyte count;Sum basophil neutrophil counts;Mean corpuscular volume;Myeloid white cell count;Sum neutrophil eosinophil counts; CRC cis rs881375 0.678 rs10760128 chr9:123696325 C/T cg14255062 chr9:123606675 PSMD5;LOC253039 0.39 6.12 0.32 2.63e-9 Rheumatoid arthritis; CRC cis rs4919694 1.000 rs75219158 chr10:104747594 C/T cg04362960 chr10:104952993 NT5C2 1.27 11.16 0.52 1.01e-24 Arsenic metabolism; CRC cis rs10504229 1.000 rs61733801 chr8:58192513 A/G cg02725872 chr8:58115012 NA -0.38 -6.43 -0.33 4.44e-10 Developmental language disorder (linguistic errors); CRC cis rs634534 0.561 rs655744 chr11:65776585 G/T cg26695010 chr11:65641043 EFEMP2 0.4 6.04 0.32 4.22e-9 Sum eosinophil basophil counts;Eosinophil counts; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg03291336 chr15:69114244 ANP32A 0.39 6.0 0.31 5.34e-9 Liver disease severity in Alagille syndrome; CRC cis rs4664293 0.836 rs4664300 chr2:160600438 A/G cg08347373 chr2:160653686 CD302 -0.47 -7.43 -0.38 9.32e-13 Monocyte percentage of white cells; CRC cis rs9381040 0.655 rs2294696 chr6:41036988 A/G cg25110423 chr6:41068646 NFYA;LOC221442 0.39 6.13 0.32 2.57e-9 Alzheimer's disease (late onset); CRC cis rs4731207 0.698 rs4728010 chr7:124481420 T/A cg23710748 chr7:124431027 NA 0.38 6.08 0.32 3.42e-9 Cutaneous malignant melanoma; CRC cis rs2635047 0.967 rs2576060 chr18:44637106 C/T cg19077165 chr18:44547161 KATNAL2 0.53 8.73 0.43 1.32e-16 Educational attainment; CRC cis rs2075165 0.901 rs759329 chr1:156230936 A/G cg20302342 chr1:156215951 PAQR6 0.41 8.14 0.41 8.28e-15 Tonsillectomy; CRC cis rs7264396 0.563 rs2425114 chr20:34322346 T/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.49 -6.55 -0.34 2.15e-10 Total cholesterol levels; CRC trans rs7824557 0.806 rs6601573 chr8:11094751 A/G cg06636001 chr8:8085503 FLJ10661 -0.44 -6.0 -0.31 5.3e-9 Retinal vascular caliber; CRC cis rs6748734 0.901 rs6720357 chr2:241830296 A/C cg16358738 chr2:241808595 AGXT -0.39 -5.82 -0.31 1.42e-8 Urinary metabolites; CRC trans rs6430538 0.646 rs6734820 chr2:135536808 A/G cg04783338 chr16:23160430 USP31 0.37 6.19 0.32 1.74e-9 Parkinson's disease; CRC cis rs2153535 0.601 rs4140585 chr6:8503298 T/A cg07606381 chr6:8435919 SLC35B3 0.67 10.75 0.51 2.69e-23 Motion sickness; CRC cis rs12024301 0.557 rs12068757 chr1:183663856 G/A cg11505048 chr1:183622726 RGL1;APOBEC4 0.71 6.24 0.33 1.33e-9 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs117623576 0.680 rs16932874 chr10:32358438 T/C cg03047570 chr10:32398778 NA -0.58 -6.48 -0.34 3.42e-10 Anti-saccade response; CRC trans rs9858542 0.953 rs11922013 chr3:49458355 G/C cg21659725 chr3:3221576 CRBN -0.66 -9.07 -0.45 1.08e-17 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs7493 1.000 rs17166875 chr7:95041271 C/T cg01874867 chr7:94954059 PON1 -0.49 -6.25 -0.33 1.27e-9 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs1552244 0.572 rs6797536 chr3:10168802 C/T cg08888203 chr3:10149979 C3orf24 -0.72 -8.96 -0.44 2.54e-17 Alzheimer's disease; CRC cis rs7914558 1.000 rs10509757 chr10:104752960 C/T cg15744005 chr10:104629667 AS3MT -0.33 -6.98 -0.36 1.65e-11 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs7811142 0.830 rs7341507 chr7:99951315 A/G cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.6 7.98 0.4 2.53e-14 Platelet count; CRC cis rs597539 0.652 rs636049 chr11:68667198 A/C cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.87 15.24 0.64 4.6e-40 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs4664293 1.000 rs4664293 chr2:160505752 T/C cg08347373 chr2:160653686 CD302 -0.38 -6.24 -0.33 1.38e-9 Monocyte percentage of white cells; CRC cis rs9905704 0.647 rs12943705 chr17:57097047 T/C cg12560992 chr17:57184187 TRIM37 -0.65 -9.89 -0.48 2.31e-20 Testicular germ cell tumor; CRC cis rs1448094 0.512 rs11503595 chr12:86244075 T/A cg18827107 chr12:86230957 RASSF9 -0.45 -7.42 -0.38 9.97e-13 Major depressive disorder; CRC cis rs2549003 0.870 rs10053046 chr5:131821558 A/G cg00255919 chr5:131827918 IRF1 0.59 11.92 0.55 1.77e-27 Asthma (sex interaction); CRC cis rs7089973 0.604 rs11196943 chr10:116598865 T/C cg23260525 chr10:116636907 FAM160B1 0.35 8.12 0.41 9.56e-15 Bipolar disorder or attention deficit hyperactivity disorder; CRC cis rs2243480 1.000 rs9769882 chr7:65642925 T/C cg18252515 chr7:66147081 NA 1.23 14.37 0.62 1.07e-36 Diabetic kidney disease; CRC cis rs28386778 0.830 rs67905415 chr17:61841236 G/A cg06873352 chr17:61820015 STRADA 0.75 14.2 0.62 5.17e-36 Prudent dietary pattern; CRC cis rs9911578 0.967 rs7214892 chr17:57065401 G/A cg05425664 chr17:57184151 TRIM37 -0.5 -7.86 -0.4 5.71e-14 Intelligence (multi-trait analysis); CRC cis rs3736485 0.844 rs79654603 chr15:51884862 G/A cg08986416 chr15:51914746 DMXL2 -0.47 -6.47 -0.34 3.6e-10 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs1552244 0.882 rs56224841 chr3:10044014 A/C cg08888203 chr3:10149979 C3orf24 0.62 8.3 0.42 2.65e-15 Alzheimer's disease; CRC cis rs9487051 0.799 rs351724 chr6:109546577 T/C cg21918786 chr6:109611834 NA -0.36 -6.1 -0.32 3e-9 Reticulocyte fraction of red cells; CRC trans rs853679 1.000 rs853694 chr6:28279100 A/T cg06606381 chr12:133084897 FBRSL1 -0.64 -6.6 -0.34 1.66e-10 Depression; CRC cis rs1865760 0.865 rs9467651 chr6:25958257 C/G cg17691542 chr6:26056736 HIST1H1C 0.55 8.4 0.42 1.36e-15 Height; CRC cis rs62103177 0.810 rs62103192 chr18:77629050 A/T cg12964065 chr18:77638022 KCNG2 0.66 6.69 0.35 9.56e-11 Opioid sensitivity; CRC cis rs801193 0.967 rs2707853 chr7:66214010 G/A cg11764359 chr7:65958608 NA 0.54 8.25 0.41 3.77e-15 Aortic root size; CRC cis rs4665809 0.938 rs4665822 chr2:26312555 C/G cg25036284 chr2:26402008 FAM59B -0.46 -6.04 -0.32 4.12e-9 Gut microbiome composition (summer); CRC cis rs6952808 0.823 rs10950448 chr7:1966492 G/C cg21782813 chr7:2030301 MAD1L1 0.47 7.68 0.39 1.82e-13 Bipolar disorder and schizophrenia; CRC cis rs7945705 0.935 rs2568062 chr11:8887945 A/G cg00186954 chr11:8933980 ST5;C11orf17 -0.44 -7.21 -0.37 3.85e-12 Hemoglobin concentration; CRC cis rs4332037 0.539 rs56180486 chr7:2050747 C/T cg13880726 chr7:1868755 MAD1L1 -0.47 -5.67 -0.3 3.11e-8 Bipolar disorder; CRC cis rs9733 0.569 rs11204691 chr1:150644339 A/T cg10589385 chr1:150898437 SETDB1 0.28 5.98 0.31 5.86e-9 Tonsillectomy; CRC cis rs10504229 1.000 rs114486414 chr8:58185103 G/A cg22535103 chr8:58192502 C8orf71 -0.82 -12.27 -0.56 9.63e-29 Developmental language disorder (linguistic errors); CRC cis rs6570726 0.905 rs430248 chr6:145874104 A/G cg23711669 chr6:146136114 FBXO30 0.71 12.43 0.57 2.4e-29 Lobe attachment (rater-scored or self-reported); CRC cis rs2836974 0.644 rs2836981 chr21:40688365 C/T cg11644478 chr21:40555479 PSMG1 -0.63 -9.83 -0.48 3.71e-20 Cognitive function; CRC cis rs11585357 0.671 rs2501776 chr1:17619279 C/T cg08277548 chr1:17600880 PADI3 0.5 7.82 0.4 7.3e-14 Hair shape; CRC cis rs6446731 0.517 rs2858087 chr4:3268892 A/T cg16416165 chr4:3325029 RGS12 -0.37 -5.69 -0.3 2.77e-8 Mean platelet volume; CRC trans rs9291683 0.679 rs3756225 chr4:10094133 G/C cg26043149 chr18:55253948 FECH -0.56 -8.84 -0.44 5.8e-17 Bone mineral density; CRC cis rs7666738 0.830 rs34212748 chr4:99068708 G/A cg17366294 chr4:99064904 C4orf37 0.43 7.32 0.37 1.87e-12 Colonoscopy-negative controls vs population controls; CRC cis rs2179367 0.959 rs9322178 chr6:149693267 G/C cg07828024 chr6:149772892 ZC3H12D -0.39 -6.26 -0.33 1.17e-9 Dupuytren's disease; CRC cis rs853679 0.517 rs9368554 chr6:28082711 T/C cg25164649 chr6:28176230 NA 0.77 9.5 0.46 4.6e-19 Depression; CRC cis rs7737355 1.000 rs6876350 chr5:130604109 G/T cg06307176 chr5:131281290 NA 0.38 5.6 0.3 4.48e-8 Life satisfaction; CRC cis rs4481887 0.800 rs4278391 chr1:248450495 C/T cg13385794 chr1:248469461 NA 0.36 6.21 0.32 1.59e-9 Common traits (Other); CRC cis rs7927771 1.000 rs12361031 chr11:47783076 G/A cg20307385 chr11:47447363 PSMC3 -0.5 -6.58 -0.34 1.83e-10 Subjective well-being; CRC cis rs2033711 0.783 rs11671113 chr19:58958087 C/T cg26874164 chr19:58962979 ZNF324B 0.4 5.6 0.3 4.47e-8 Uric acid clearance; CRC cis rs7666738 0.830 rs13116691 chr4:98929771 A/C cg17366294 chr4:99064904 C4orf37 0.43 7.32 0.37 1.95e-12 Colonoscopy-negative controls vs population controls; CRC cis rs7809950 0.678 rs77395658 chr7:107000651 G/A cg23024343 chr7:107201750 COG5 -0.75 -10.32 -0.49 8.2e-22 Coronary artery disease; CRC cis rs9916302 0.706 rs597069 chr17:37458512 G/T cg00129232 chr17:37814104 STARD3 0.57 6.78 0.35 5.6e-11 Glomerular filtration rate (creatinine); CRC cis rs6502050 0.835 rs35192339 chr17:80119106 G/A cg11859384 chr17:80120422 CCDC57 -0.36 -5.75 -0.3 2.06e-8 Life satisfaction; CRC cis rs11971779 0.590 rs9642120 chr7:139083971 C/T cg23387468 chr7:139079360 LUC7L2 0.41 7.04 0.36 1.14e-11 Diisocyanate-induced asthma; CRC cis rs6951245 1.000 rs28379681 chr7:1070539 C/T cg22907277 chr7:1156413 C7orf50 0.71 7.39 0.38 1.26e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs7937682 0.575 rs7114617 chr11:111768173 A/T cg09085632 chr11:111637200 PPP2R1B 0.95 15.73 0.66 5.97e-42 Primary sclerosing cholangitis; CRC cis rs11148252 0.740 rs9596642 chr13:52900879 A/G cg00495681 chr13:53174319 NA -0.55 -7.99 -0.4 2.32e-14 Lewy body disease; CRC cis rs8180040 0.620 rs11720139 chr3:47036756 C/G cg27129171 chr3:47204927 SETD2 -0.72 -11.48 -0.53 7.21e-26 Colorectal cancer; CRC cis rs12220238 1.000 rs10824114 chr10:75970503 T/A cg19889307 chr10:75911429 ADK;AP3M1 0.54 5.61 0.3 4.26e-8 Soluble interleukin-2 receptor subunit alpha; CRC cis rs9487051 0.898 rs882072 chr6:109611806 A/G cg01475377 chr6:109611718 NA -0.49 -9.17 -0.45 5.13e-18 Reticulocyte fraction of red cells; CRC cis rs950776 0.648 rs57945453 chr15:78862845 C/T cg06917634 chr15:78832804 PSMA4 0.61 8.91 0.44 3.57e-17 Sudden cardiac arrest; CRC cis rs10751667 0.666 rs7934963 chr11:957220 C/T cg23136738 chr11:925521 AP2A2 -0.4 -6.71 -0.35 8.59e-11 Alzheimer's disease (late onset); CRC cis rs6534441 0.579 rs312496 chr4:125449506 C/A cg21609808 chr4:125404261 NA 0.36 5.78 0.3 1.76e-8 Major depressive disorder; CRC cis rs523522 0.923 rs3916065 chr12:120934624 A/C cg12219531 chr12:120966889 COQ5 0.69 9.31 0.46 1.85e-18 High light scatter reticulocyte count; CRC cis rs7412746 0.658 rs4970986 chr1:150907955 A/G cg10589385 chr1:150898437 SETDB1 0.32 6.83 0.35 4.05e-11 Melanoma; CRC cis rs13064411 0.696 rs1486897 chr3:113215818 G/A cg18753928 chr3:113234510 CCDC52 -0.69 -10.56 -0.5 1.26e-22 Response to simvastatin treatment (PCSK9 protein level change); CRC cis rs9660180 0.868 rs72634846 chr1:1704915 C/G cg23982607 chr1:1823379 GNB1 -0.86 -15.13 -0.64 1.29e-39 Body mass index; CRC trans rs11764590 0.715 rs55810445 chr7:2103739 C/T cg11693508 chr17:37793320 STARD3 0.57 6.51 0.34 2.86e-10 Neuroticism; CRC cis rs10207060 0.500 rs62183161 chr2:240699856 C/T cg07506560 chr2:240697449 NA 0.52 6.81 0.35 4.54e-11 Obesity-related traits; CRC cis rs1873147 0.569 rs8029221 chr15:63308583 C/T cg12160578 chr15:63334699 TPM1 0.61 7.2 0.37 4.11e-12 Orofacial clefts; CRC cis rs2249694 0.919 rs7093170 chr10:135402904 C/T cg16964102 chr10:135390573 NA 0.43 7.16 0.37 5.46e-12 Obesity-related traits; CRC cis rs7940866 0.770 rs10750456 chr11:130819634 A/G cg12179176 chr11:130786555 SNX19 0.65 9.35 0.46 1.35e-18 Schizophrenia; CRC cis rs1799949 1.000 rs2175957 chr17:41286822 T/G cg01879757 chr17:41196368 BRCA1 -0.44 -6.63 -0.34 1.35e-10 Menopause (age at onset); CRC cis rs7107174 1.000 rs2510049 chr11:77985459 G/T cg02023728 chr11:77925099 USP35 0.51 7.42 0.38 1e-12 Testicular germ cell tumor; CRC cis rs10504229 0.645 rs56670121 chr8:58138872 C/T cg02290350 chr8:58132656 NA -0.58 -8.13 -0.41 9.08e-15 Developmental language disorder (linguistic errors); CRC cis rs4925325 0.741 rs6142886 chr20:60511190 A/G cg18761221 chr20:60518478 NA -0.69 -12.5 -0.57 1.38e-29 Obesity-related traits; CRC cis rs896854 0.654 rs13281625 chr8:95972738 T/C cg23172400 chr8:95962367 TP53INP1 -0.48 -8.19 -0.41 5.98e-15 Type 2 diabetes; CRC cis rs861020 1.000 rs12134698 chr1:209987801 C/A cg09163369 chr1:210001066 C1orf107 -0.6 -7.61 -0.39 2.87e-13 Orofacial clefts; CRC cis rs7772486 0.686 rs6570701 chr6:145954090 A/G cg23711669 chr6:146136114 FBXO30 0.67 11.13 0.52 1.28e-24 Lobe attachment (rater-scored or self-reported); CRC cis rs10504229 0.595 rs77615399 chr8:58117394 C/G cg24829409 chr8:58192753 C8orf71 -0.55 -8.03 -0.4 1.71e-14 Developmental language disorder (linguistic errors); CRC cis rs4588572 0.606 rs2362828 chr5:77718835 C/T cg11446398 chr5:77624930 NA 0.41 5.97 0.31 6.26e-9 Triglycerides; CRC cis rs6500395 0.962 rs9937623 chr16:48571590 A/T cg04672837 chr16:48644449 N4BP1 -0.42 -6.03 -0.32 4.29e-9 Response to tocilizumab in rheumatoid arthritis; CRC cis rs7044106 0.708 rs10760113 chr9:123474050 T/C cg14255062 chr9:123606675 PSMD5;LOC253039 0.47 7.08 0.36 8.82e-12 Hip circumference adjusted for BMI; CRC cis rs10208940 0.920 rs11886343 chr2:68750336 G/A cg12452813 chr2:68675892 NA 0.48 6.05 0.32 4.01e-9 Urate levels in lean individuals; CRC cis rs11098499 0.866 rs7665125 chr4:120402079 G/T cg24375607 chr4:120327624 NA 0.43 6.59 0.34 1.71e-10 Corneal astigmatism; CRC cis rs1799949 1.000 rs4793192 chr17:41204390 T/C cg25072359 chr17:41440525 NA 0.45 6.82 0.35 4.26e-11 Menopause (age at onset); CRC cis rs1878931 0.543 rs17612463 chr16:3420479 G/C cg26668626 chr16:3451006 ZNF174;ZNF434 0.57 7.08 0.36 8.83e-12 Body mass index (adult); CRC cis rs7617480 0.558 rs12715430 chr3:48942855 A/C cg20833759 chr3:49053208 WDR6;DALRD3 0.73 11.45 0.53 9.19e-26 Subjective well-being (multi-trait analysis);Menarche (age at onset); CRC cis rs4561483 0.556 rs11570136 chr16:12058832 T/A cg08843971 chr16:11963173 GSPT1 -0.54 -7.2 -0.37 4e-12 Testicular germ cell tumor; CRC cis rs2160860 0.729 rs6984887 chr8:39801352 C/T cg11363097 chr8:39792086 IDO2 -0.45 -7.57 -0.39 3.81e-13 Blood metabolite levels; CRC cis rs4642101 0.511 rs9809596 chr3:12840513 C/G cg24848339 chr3:12840334 CAND2 0.35 6.52 0.34 2.6e-10 QRS complex (12-leadsum); CRC cis rs1552244 0.935 rs7621551 chr3:10114205 C/T cg02579736 chr3:10068473 FANCD2;CIDECP 1.02 13.77 0.6 2.25e-34 Alzheimer's disease; CRC cis rs1153858 0.945 rs7182300 chr15:45634928 G/A cg14582100 chr15:45693742 SPATA5L1 0.28 5.82 0.31 1.43e-8 Homoarginine levels; CRC cis rs6952808 0.510 rs13227554 chr7:2048220 G/C cg00106254 chr7:1943704 MAD1L1 0.41 6.28 0.33 1.08e-9 Bipolar disorder and schizophrenia; CRC trans rs2553218 0.690 rs8032415 chr15:54851945 A/G cg07307426 chr15:89089587 DET1 0.5 6.68 0.35 1.05e-10 Immune response to smallpox vaccine (IL-6); CRC cis rs6543140 0.964 rs62154972 chr2:103048738 G/A cg09003973 chr2:102972529 NA 0.41 5.61 0.3 4.31e-8 Blood protein levels; CRC cis rs1005277 0.579 rs2474584 chr10:38416389 C/T cg17219203 chr10:38645113 HSD17B7P2 -0.4 -5.66 -0.3 3.24e-8 Extrinsic epigenetic age acceleration; CRC cis rs2303745 0.589 rs11086065 chr19:17395003 A/G cg15110403 chr19:17392923 ANKLE1 -0.36 -6.09 -0.32 3.13e-9 Systemic lupus erythematosus; CRC cis rs2976388 0.609 rs2572907 chr8:143801938 G/A cg24046110 chr8:143859143 LYNX1 0.45 7.75 0.39 1.17e-13 Urinary tract infection frequency; CRC cis rs736408 0.677 rs2286798 chr3:52821177 G/T cg11645453 chr3:52864694 ITIH4 -0.4 -7.22 -0.37 3.72e-12 Bipolar disorder; CRC cis rs13108904 0.934 rs13125338 chr4:1278435 A/C cg19318889 chr4:1322082 MAEA 0.4 5.74 0.3 2.13e-8 Obesity-related traits; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg08693344 chr16:56691562 MT1F 0.39 6.86 0.35 3.38e-11 Liver disease severity in Alagille syndrome; CRC cis rs394563 0.559 rs13219868 chr6:149686518 T/G cg11245181 chr6:149772854 ZC3H12D 0.54 9.56 0.47 2.95e-19 Dupuytren's disease; CRC cis rs1448094 0.549 rs7297996 chr12:86235899 C/T cg18827107 chr12:86230957 RASSF9 -0.49 -8.07 -0.41 1.3e-14 Major depressive disorder; CRC cis rs7811142 1.000 rs74460138 chr7:100027339 C/G cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.62 8.09 0.41 1.16e-14 Platelet count; CRC cis rs4700695 0.841 rs251614 chr5:65228251 C/G cg21114390 chr5:65439923 SFRS12 -0.5 -6.32 -0.33 8.68e-10 Facial morphology (factor 19); CRC cis rs6563739 0.655 rs4254189 chr13:40212417 G/A cg00026919 chr13:40226031 NA 0.45 5.68 0.3 3e-8 Menarche (age at onset); CRC cis rs10791323 0.604 rs2723607 chr11:133711018 C/G cg15485101 chr11:133734466 NA 0.45 7.7 0.39 1.65e-13 Childhood ear infection; CRC cis rs6076065 0.723 rs2424536 chr20:23381601 C/T cg11657817 chr20:23433608 CST11 0.45 6.71 0.35 8.65e-11 Facial morphology (factor 15, philtrum width); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg23761332 chr2:208393956 CREB1 0.44 6.47 0.34 3.49e-10 Response to antipsychotic treatment; CRC cis rs1707322 0.685 rs11211177 chr1:46226349 A/G cg03146154 chr1:46216737 IPP 0.64 9.05 0.45 1.31e-17 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs2180341 0.782 rs4897214 chr6:127723625 G/T cg24812749 chr6:127587940 RNF146 0.68 9.21 0.45 4.07e-18 Breast cancer; CRC cis rs10504229 0.689 rs17801390 chr8:58054768 T/C cg22535103 chr8:58192502 C8orf71 -0.8 -8.67 -0.43 1.93e-16 Developmental language disorder (linguistic errors); CRC cis rs11098499 0.909 rs2127821 chr4:120394535 T/C cg24375607 chr4:120327624 NA 0.49 7.62 0.39 2.77e-13 Corneal astigmatism; CRC cis rs9733 0.596 rs12086472 chr1:150697710 G/A cg17724175 chr1:150552817 MCL1 0.57 9.12 0.45 7.76e-18 Tonsillectomy; CRC cis rs7274811 0.625 rs169797 chr20:31926490 G/A cg21523528 chr20:32077966 CBFA2T2 -0.4 -5.64 -0.3 3.72e-8 Height; CRC trans rs9393777 0.920 rs34150729 chr6:27388754 T/C cg16898833 chr6:26189333 HIST1H4D 0.95 6.45 0.34 3.99e-10 Intelligence (multi-trait analysis); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg18679886 chr7:107531975 DLD 0.45 6.23 0.32 1.41e-9 Response to antipsychotic treatment; CRC trans rs1569175 0.850 rs3106088 chr2:200907393 A/C cg19477977 chr2:235599692 NA 0.68 6.16 0.32 2.09e-9 Response to treatment for acute lymphoblastic leukemia; CRC cis rs763121 0.853 rs5750659 chr22:39068789 T/C cg06022373 chr22:39101656 GTPBP1 0.8 12.62 0.57 4.84e-30 Menopause (age at onset); CRC cis rs17376456 0.877 rs9314093 chr5:93333347 G/A cg09848695 chr5:92956644 FAM172A;MIR2277 0.63 5.6 0.3 4.5e-8 Diabetic retinopathy; CRC cis rs7772486 0.686 rs9390348 chr6:146044748 C/T cg13319975 chr6:146136371 FBXO30 0.43 6.45 0.34 3.96e-10 Lobe attachment (rater-scored or self-reported); CRC trans rs9393777 0.778 rs77666565 chr6:26851415 G/A cg06606381 chr12:133084897 FBRSL1 -1.04 -7.49 -0.38 6.29e-13 Intelligence (multi-trait analysis); CRC cis rs11190604 0.767 rs4919458 chr10:102177728 G/A cg07080220 chr10:102295463 HIF1AN -0.46 -6.02 -0.32 4.6e-9 Palmitoleic acid (16:1n-7) levels; CRC trans rs12699921 0.566 rs2723515 chr7:17855466 A/G cg02066331 chr6:17282778 RBM24 -0.36 -6.25 -0.33 1.27e-9 Fibrinogen levels; CRC cis rs3790844 0.515 rs35094784 chr1:199949274 T/C cg07208853 chr1:200005219 NR5A2 0.35 8.83 0.44 6.14e-17 Pancreatic cancer; CRC cis rs9487051 0.652 rs13210424 chr6:109598737 G/A cg21918786 chr6:109611834 NA -0.4 -7.13 -0.37 6.33e-12 Reticulocyte fraction of red cells; CRC cis rs6502050 0.805 rs7225560 chr17:80160884 C/G cg02741985 chr17:80059408 CCDC57 0.44 7.21 0.37 3.78e-12 Life satisfaction; CRC cis rs1552244 1.000 rs6789156 chr3:10124120 C/T cg16606324 chr3:10149918 C3orf24 0.71 9.54 0.47 3.33e-19 Alzheimer's disease; CRC cis rs6951245 0.872 rs113119264 chr7:1080564 G/A cg24642844 chr7:1081250 C7orf50 -0.78 -9.34 -0.46 1.44e-18 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs6088590 0.965 rs6120727 chr20:33374102 T/C cg08999081 chr20:33150536 PIGU 0.51 8.48 0.42 7.61e-16 Coronary artery disease; CRC cis rs3760982 1.000 rs12460161 chr19:44293986 C/A cg11993925 chr19:44307056 LYPD5 0.47 7.74 0.39 1.25e-13 Breast cancer (estrogen-receptor negative);Breast cancer; CRC cis rs853679 0.517 rs4713145 chr6:28106827 T/C cg02683197 chr6:28174875 NA 0.85 10.52 0.5 1.71e-22 Depression; CRC cis rs853679 0.517 rs4713137 chr6:28083521 C/G cg02683197 chr6:28174875 NA 0.85 10.27 0.49 1.16e-21 Depression; CRC cis rs34779708 0.733 rs12243593 chr10:35549045 C/T cg03585969 chr10:35415529 CREM 0.52 6.79 0.35 5.37e-11 Inflammatory bowel disease;Crohn's disease; CRC cis rs1045714 0.887 rs73033694 chr7:2637139 G/A cg24848437 chr7:2645542 IQCE 0.59 6.09 0.32 3.21e-9 Urate levels in lean individuals; CRC cis rs72781680 1.000 rs72781663 chr2:24221694 C/G cg08917208 chr2:24149416 ATAD2B 0.88 8.67 0.43 1.96e-16 Lymphocyte counts; CRC cis rs9733 0.570 rs951281 chr1:150691122 A/C cg15448220 chr1:150897856 SETDB1 0.45 6.41 0.33 5.09e-10 Tonsillectomy; CRC cis rs477895 1.000 rs1047206 chr11:64089216 C/G cg18225595 chr11:63971243 STIP1 0.59 6.24 0.33 1.35e-9 Mean platelet volume; CRC cis rs62408225 0.962 rs905671 chr6:90983850 A/T cg06866423 chr6:90926672 BACH2 0.48 8.03 0.4 1.74e-14 Eosinophil counts;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC cis rs7147624 0.572 rs72714470 chr14:65979173 G/A cg03016385 chr14:66212404 NA 1.02 7.99 0.4 2.32e-14 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs7617773 0.817 rs3731534 chr3:48211777 C/T cg11946769 chr3:48343235 NME6 0.73 9.9 0.48 2.21e-20 Coronary artery disease; CRC cis rs28386778 0.897 rs2859619 chr17:61917686 T/C cg11494091 chr17:61959527 GH2 0.63 10.75 0.51 2.7e-23 Prudent dietary pattern; CRC cis rs45509595 0.841 rs370155 chr6:27782031 T/G cg15845792 chr6:28175446 NA 0.73 6.45 0.34 3.9e-10 Breast cancer; CRC cis rs4964805 0.865 rs4964289 chr12:104204191 G/A cg02344784 chr12:104178138 NT5DC3 0.49 6.8 0.35 4.83e-11 Attention deficit hyperactivity disorder; CRC cis rs6701037 0.714 rs2285219 chr1:175130983 A/T cg00321850 chr1:175162397 KIAA0040 -0.42 -6.86 -0.35 3.45e-11 Alcohol dependence; CRC cis rs3733585 0.699 rs6834893 chr4:9959123 C/T cg11266682 chr4:10021025 SLC2A9 -0.47 -9.67 -0.47 1.2e-19 Cleft plate (environmental tobacco smoke interaction); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg14107975 chr11:96076498 MAML2 0.41 6.71 0.35 8.76e-11 Liver disease severity in Alagille syndrome; CRC trans rs2303319 0.504 rs1023835 chr2:162593973 A/G cg03774468 chr3:140950104 ACPL2 -0.65 -6.07 -0.32 3.61e-9 Cognitive function; CRC cis rs2857891 1.000 rs2857891 chr11:6962957 C/T cg14883916 chr11:6947541 ZNF215 0.62 6.8 0.35 5e-11 Response to cytadine analogues (cytosine arabinoside); CRC cis rs1799949 1.000 rs1824889 chr17:41421876 C/G cg01879757 chr17:41196368 BRCA1 -0.43 -6.63 -0.34 1.39e-10 Menopause (age at onset); CRC cis rs1003719 0.715 rs2835639 chr21:38537016 G/C cg10648535 chr21:38446584 PIGP;TTC3 -0.47 -6.51 -0.34 2.83e-10 Eye color traits; CRC cis rs2108622 0.727 rs3093193 chr19:15991914 C/G cg13772218 chr19:15982569 NA 0.48 6.83 0.35 4e-11 Circulating phylloquinone levels;Vitamin E levels;Acenocoumarol maintenance dosage;Response to Vitamin E supplementation;Metabolite levels;Warfarin maintenance dose; CRC cis rs1552244 0.554 rs55847233 chr3:9991101 C/G cg16606324 chr3:10149918 C3orf24 0.47 7.29 0.37 2.29e-12 Alzheimer's disease; CRC trans rs11098499 0.955 rs1397608 chr4:120161744 A/G cg25214090 chr10:38739885 LOC399744 0.52 8.02 0.4 1.94e-14 Corneal astigmatism; CRC cis rs4638749 0.677 rs6755598 chr2:108827674 G/C cg25838818 chr2:108905173 SULT1C2 -0.34 -5.78 -0.3 1.76e-8 Blood pressure; CRC cis rs644799 0.562 rs1313288 chr11:95520695 T/C cg25622487 chr11:95524042 FAM76B;CEP57 0.57 8.65 0.43 2.34e-16 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs9926296 0.512 rs11076626 chr16:89865103 T/A cg04287289 chr16:89883240 FANCA 0.83 15.49 0.65 4.79e-41 Vitiligo; CRC cis rs9341808 0.935 rs942381 chr6:80880150 T/G cg08355045 chr6:80787529 NA 0.37 6.28 0.33 1.06e-9 Sitting height ratio; CRC cis rs35306767 0.855 rs61830931 chr10:932497 T/C cg26597838 chr10:835615 NA 1.23 14.5 0.62 3.54e-37 Eosinophil percentage of granulocytes; CRC cis rs4481887 0.927 rs4581306 chr1:248476158 C/A cg13385794 chr1:248469461 NA 0.38 6.75 0.35 6.84e-11 Common traits (Other); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg14663065 chr3:41241630 CTNNB1 0.45 6.53 0.34 2.48e-10 Intelligence (multi-trait analysis); CRC cis rs9300255 0.602 rs2851435 chr12:123712416 G/A cg00376283 chr12:123451042 ABCB9 0.5 6.08 0.32 3.3e-9 Neutrophil percentage of white cells; CRC cis rs3771570 1.000 rs62193205 chr2:242316512 C/T cg21155796 chr2:242212141 HDLBP 0.65 7.01 0.36 1.34e-11 Prostate cancer; CRC cis rs853679 0.517 rs9393888 chr6:28059217 G/C cg23161317 chr6:28129485 ZNF389 0.52 6.35 0.33 6.97e-10 Depression; CRC trans rs1814175 0.904 rs7924371 chr11:49620595 C/T cg15704280 chr7:45808275 SEPT13 -0.97 -18.03 -0.7 5.04e-51 Height; CRC cis rs995000 0.899 rs1781212 chr1:62977419 G/A cg19896129 chr1:63156450 NA -0.45 -6.91 -0.36 2.54e-11 Triglyceride levels; CRC trans rs747782 0.528 rs4370963 chr11:48433943 C/G cg03929089 chr4:120376271 NA 0.65 6.3 0.33 9.41e-10 Intraocular pressure; CRC cis rs7208859 0.623 rs8067338 chr17:29102345 T/C cg13385521 chr17:29058706 SUZ12P 0.73 8.33 0.42 2.14e-15 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs4285028 0.747 rs7610298 chr3:121419100 T/A cg20356878 chr3:121714668 ILDR1 -0.42 -5.99 -0.31 5.37e-9 Multiple sclerosis; CRC cis rs4862750 0.957 rs6858853 chr4:187903412 A/C cg11301795 chr4:187892539 NA 0.88 19.92 0.74 1.77e-58 Lobe attachment (rater-scored or self-reported); CRC cis rs172166 0.637 rs1225595 chr6:28151340 A/T cg12172441 chr6:28176163 NA 0.59 8.41 0.42 1.23e-15 Cardiac Troponin-T levels; CRC cis rs79387448 0.745 rs6742433 chr2:103175360 C/T cg09003973 chr2:102972529 NA 0.72 7.88 0.4 4.83e-14 Gut microbiota (bacterial taxa); CRC cis rs1801251 1.000 rs283477 chr2:233649427 A/G cg25237894 chr2:233734115 C2orf82 0.56 9.06 0.45 1.16e-17 Coronary artery disease; CRC trans rs2303319 0.504 rs1006427 chr2:162592328 T/C cg04551154 chr10:95462393 C10orf4 -0.75 -6.37 -0.33 6.43e-10 Cognitive function; CRC cis rs929354 0.772 rs3802123 chr7:156970641 G/A cg16102536 chr7:156981717 UBE3C 0.41 6.77 0.35 5.78e-11 Body mass index; CRC cis rs9911578 1.000 rs304270 chr17:56802141 A/G cg05425664 chr17:57184151 TRIM37 0.51 8.18 0.41 6.39e-15 Intelligence (multi-trait analysis); CRC cis rs4423214 1.000 rs12793530 chr11:71161656 G/A cg05163923 chr11:71159392 DHCR7 0.67 9.53 0.46 3.69e-19 Vitamin D levels; CRC cis rs2836950 0.545 rs11701805 chr21:40618683 T/C cg11890956 chr21:40555474 PSMG1 -0.66 -9.67 -0.47 1.25e-19 Menarche (age at onset); CRC cis rs478304 0.903 rs546202 chr11:65510024 C/T cg27068330 chr11:65405492 SIPA1 -0.42 -6.15 -0.32 2.29e-9 Acne (severe); CRC cis rs6582630 0.519 rs11182457 chr12:38538331 G/A cg26384229 chr12:38710491 ALG10B 0.71 9.58 0.47 2.43e-19 Drug-induced liver injury (flucloxacillin); CRC cis rs4722166 0.630 rs6461667 chr7:22796743 A/G cg05472934 chr7:22766657 IL6 0.78 12.63 0.57 4.43e-30 Lung cancer; CRC cis rs875971 0.862 rs6460302 chr7:65960257 C/G cg12463550 chr7:65579703 CRCP 0.5 7.02 0.36 1.31e-11 Aortic root size; CRC cis rs17021463 0.966 rs10856908 chr4:95222755 G/T cg11021082 chr4:95130006 SMARCAD1 -0.56 -9.11 -0.45 7.97e-18 Testicular germ cell tumor; CRC cis rs6032067 0.777 rs80323300 chr20:43785287 T/C cg10761708 chr20:43804764 PI3 0.48 5.62 0.3 4.06e-8 Blood protein levels; CRC cis rs4713118 0.662 rs9357060 chr6:28024486 C/G cg12172441 chr6:28176163 NA 0.56 7.16 0.37 5.25e-12 Parkinson's disease; CRC cis rs12540874 0.663 rs1451371 chr7:50553051 T/C cg18232548 chr7:50535776 DDC -0.56 -8.47 -0.42 8.28e-16 Systemic sclerosis; CRC cis rs9322193 0.887 rs11155662 chr6:149913867 T/G cg05861140 chr6:150128134 PCMT1 -0.4 -6.11 -0.32 2.88e-9 Lung cancer; CRC cis rs9611519 0.828 rs4822008 chr22:41539206 C/G cg06634786 chr22:41940651 POLR3H -0.49 -6.18 -0.32 1.93e-9 Neuroticism; CRC cis rs6912958 0.728 rs6923230 chr6:88213949 T/C cg08069147 chr6:88032118 GJB7;C6orf162 -0.55 -8.18 -0.41 6.43e-15 Monocyte percentage of white cells; CRC cis rs853679 0.517 rs56310871 chr6:28044482 A/G cg12273811 chr6:28175739 NA 0.69 8.83 0.44 6.17e-17 Depression; CRC cis rs870825 0.616 rs6552805 chr4:185637894 C/A cg04058563 chr4:185651563 MLF1IP 0.73 9.38 0.46 1.13e-18 Blood protein levels; CRC cis rs9322193 0.962 rs9393175 chr6:149998723 A/G cg00933542 chr6:150070202 PCMT1 0.31 6.22 0.32 1.55e-9 Lung cancer; CRC cis rs41271951 0.512 rs115968379 chr1:151050087 A/C cg11822372 chr1:151115635 SEMA6C -0.7 -5.62 -0.3 4.02e-8 Blood protein levels; CRC cis rs447 0.895 rs1468345 chr7:83748974 A/G cg22846510 chr7:83753280 SEMA3A -0.6 -7.79 -0.39 8.91e-14 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs12474201 0.889 rs2346878 chr2:46922870 C/T cg06386533 chr2:46925753 SOCS5 0.83 13.69 0.6 4.6e-34 Height; CRC cis rs1443512 0.812 rs4759058 chr12:54339052 C/A cg17410650 chr12:54324560 NA -0.34 -6.15 -0.32 2.31e-9 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for BMI in non-smokers;Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction);Waist-hip ratio;Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour); CRC cis rs9649213 0.593 rs13246843 chr7:98002661 G/T cg24562669 chr7:97807699 LMTK2 0.44 7.29 0.37 2.39e-12 Prostate cancer (SNP x SNP interaction); CRC cis rs1799949 0.965 rs8176140 chr17:41251646 T/A cg19454999 chr17:41278357 BRCA1;NBR2 0.56 8.68 0.43 1.81e-16 Menopause (age at onset); CRC cis rs6831352 0.837 rs2924583 chr4:100044640 T/C cg12011299 chr4:100065546 ADH4 0.5 9.54 0.47 3.24e-19 Alcohol dependence; CRC cis rs728616 0.717 rs61860016 chr10:81915889 G/C cg11900509 chr10:81946545 ANXA11 -0.69 -7.23 -0.37 3.49e-12 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs508618 1.000 rs508618 chr1:231532312 C/T cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.54 -5.74 -0.3 2.19e-8 Red blood cell count; CRC cis rs10504229 0.595 rs36081958 chr8:58117505 C/G cg02290350 chr8:58132656 NA -0.57 -7.91 -0.4 4.05e-14 Developmental language disorder (linguistic errors); CRC cis rs6502050 0.835 rs10163485 chr17:80110750 C/T cg09264619 chr17:80180166 NA -0.34 -5.81 -0.3 1.5e-8 Life satisfaction; CRC cis rs9311474 0.607 rs28661185 chr3:52567188 G/T cg07507251 chr3:52567010 NT5DC2 0.49 7.41 0.38 1.06e-12 Electroencephalogram traits; CRC cis rs79387448 0.810 rs76229479 chr2:103123912 A/C cg09003973 chr2:102972529 NA 0.86 9.04 0.45 1.43e-17 Gut microbiota (bacterial taxa); CRC cis rs881375 0.967 rs1014529 chr9:123684943 C/G cg00246817 chr9:123691163 NA -0.47 -6.01 -0.31 4.99e-9 Rheumatoid arthritis; CRC cis rs736408 0.677 rs678 chr3:52820981 A/T cg18099408 chr3:52552593 STAB1 -0.42 -6.57 -0.34 1.92e-10 Bipolar disorder; CRC cis rs6662572 0.703 rs56278140 chr1:46357544 G/A cg08644498 chr1:46502608 NA 0.44 6.84 0.35 3.82e-11 Blood protein levels; CRC cis rs72781680 0.846 rs72782114 chr2:24025740 G/A cg08917208 chr2:24149416 ATAD2B 0.87 8.64 0.43 2.57e-16 Lymphocyte counts; CRC cis rs60843830 0.661 rs6755432 chr2:106692 T/C cg25945732 chr2:264204 ACP1;SH3YL1 0.48 6.66 0.34 1.16e-10 Spherical equivalent (joint analysis main effects and education interaction); CRC cis rs7937682 0.961 rs7106104 chr11:111635655 T/C cg19812747 chr11:111475976 SIK2 0.5 7.91 0.4 4.01e-14 Primary sclerosing cholangitis; CRC cis rs2832191 0.740 rs13048618 chr21:30458684 A/G cg08807101 chr21:30365312 RNF160 0.72 11.65 0.54 1.67e-26 Dental caries; CRC cis rs738322 0.967 rs133017 chr22:38572637 A/C cg25457927 chr22:38595422 NA -0.36 -7.57 -0.39 3.83e-13 Cutaneous nevi; CRC cis rs7121446 0.520 rs7943463 chr11:121850960 T/C cg13820391 chr11:121835505 NA 0.33 5.91 0.31 8.74e-9 Cardiovascular risk factors (age interaction); CRC cis rs7772486 0.655 rs2142981 chr6:146071695 G/C cg13319975 chr6:146136371 FBXO30 0.45 6.64 0.34 1.27e-10 Lobe attachment (rater-scored or self-reported); CRC cis rs6570726 0.791 rs365747 chr6:145866784 C/T cg13319975 chr6:146136371 FBXO30 -0.46 -6.85 -0.35 3.67e-11 Lobe attachment (rater-scored or self-reported); CRC cis rs9733 0.596 rs17658705 chr1:150678071 A/C cg10589385 chr1:150898437 SETDB1 -0.29 -6.14 -0.32 2.37e-9 Tonsillectomy; CRC cis rs2404602 0.536 rs12915248 chr15:76765615 A/T cg03037974 chr15:76606532 NA 0.66 11.45 0.53 9.04e-26 Blood metabolite levels; CRC cis rs3751196 0.808 rs74623221 chr12:104211491 C/T cg02344784 chr12:104178138 NT5DC3 0.71 7.54 0.38 4.58e-13 Sense of smell; CRC cis rs1707322 1.000 rs11211217 chr1:46348229 C/G cg06784218 chr1:46089804 CCDC17 0.52 9.12 0.45 7.89e-18 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC trans rs1455244 0.700 rs7229302 chr18:11508904 G/T cg09175928 chr16:68344995 PRMT7;SLC7A6OS 0.42 6.31 0.33 9.16e-10 Schizophrenia; CRC cis rs2425143 0.915 rs6060597 chr20:34370100 G/A cg04508476 chr20:34239394 CPNE1;RBM12 0.48 6.08 0.32 3.36e-9 Blood protein levels; CRC cis rs7727544 0.660 rs274563 chr5:131717859 C/A cg07395648 chr5:131743802 NA 0.42 6.66 0.34 1.15e-10 Blood metabolite levels; CRC cis rs460214 0.576 rs28446127 chr21:40029568 C/A cg21578987 chr21:40029669 ERG 0.41 5.9 0.31 8.85e-9 Response to cognitive-behavioural therapy in anxiety disorder; CRC cis rs9487051 0.604 rs9320282 chr6:109619377 A/G cg01475377 chr6:109611718 NA -0.37 -6.34 -0.33 7.72e-10 Reticulocyte fraction of red cells; CRC cis rs6701037 0.512 rs4650716 chr1:175128711 C/A cg14847009 chr1:175162515 KIAA0040 0.3 6.81 0.35 4.78e-11 Alcohol dependence; CRC cis rs12497850 0.931 rs7627404 chr3:48819668 A/C cg20833759 chr3:49053208 WDR6;DALRD3 0.53 9.0 0.44 1.83e-17 Parkinson's disease; CRC cis rs9467711 0.591 rs13196552 chr6:25974204 A/G cg08501292 chr6:25962987 TRIM38 0.82 7.5 0.38 6.11e-13 Autism spectrum disorder or schizophrenia; CRC cis rs10464366 1.000 rs10951593 chr7:39121390 C/T cg18850127 chr7:39170497 POU6F2 0.46 5.97 0.31 6.09e-9 IgG glycosylation; CRC cis rs62064224 0.902 rs35830939 chr17:30627564 A/C cg18200150 chr17:30822561 MYO1D 0.61 12.61 0.57 5.09e-30 Schizophrenia; CRC cis rs929354 1.000 rs1182452 chr7:157053618 G/A cg05182265 chr7:156933206 UBE3C 0.68 12.41 0.56 2.84e-29 Body mass index; CRC cis rs16973500 0.732 rs1549292 chr16:71983664 A/C cg00732059 chr16:71740210 PHLPP2 -0.64 -6.67 -0.35 1.1e-10 Response to anti-TNF therapy in rheumatoid arthritis;Attention deficit hyperactivity disorder and conduct disorder; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg03424826 chr18:59561551 RNF152 0.42 6.86 0.35 3.4e-11 Liver disease severity in Alagille syndrome; CRC cis rs11229555 0.645 rs10896775 chr11:58175989 A/T cg15696309 chr11:58395628 NA -0.81 -10.45 -0.5 2.9e-22 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; CRC cis rs1552244 1.000 rs67134728 chr3:10151431 G/C cg10729496 chr3:10149963 C3orf24 0.55 7.08 0.36 8.63e-12 Alzheimer's disease; CRC cis rs1997103 0.906 rs6593231 chr7:55402914 T/A cg17469321 chr7:55412551 NA 0.73 11.31 0.53 2.87e-25 QRS interval (sulfonylurea treatment interaction); CRC cis rs8072100 0.967 rs2317826 chr17:45730899 C/T cg08085267 chr17:45401833 C17orf57 -0.65 -10.53 -0.5 1.5e-22 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs8077889 0.917 rs58080788 chr17:41902909 A/G cg25876840 chr17:41920477 NA 0.53 7.88 0.4 4.83e-14 Triglycerides; CRC cis rs2257205 0.667 rs78253932 chr17:56804101 C/G cg25885038 chr17:56607967 SEPT4 -0.52 -5.71 -0.3 2.5e-8 Pancreatic cancer; CRC cis rs9322193 0.923 rs1413654 chr6:150105092 G/A cg13206674 chr6:150067644 NUP43 0.57 8.14 0.41 8.29e-15 Lung cancer; CRC cis rs3820068 0.581 rs59684759 chr1:15919893 A/G cg24675056 chr1:15929824 NA 0.47 6.26 0.33 1.2e-9 Systolic blood pressure; CRC cis rs898097 0.812 rs55794221 chr17:80849003 G/A cg15369054 chr17:80825471 TBCD 0.55 8.97 0.44 2.3e-17 Breast cancer; CRC cis rs2625529 0.652 rs7497104 chr15:72154000 C/T cg16672083 chr15:72433130 SENP8 -0.47 -7.16 -0.37 5.35e-12 Red blood cell count; CRC cis rs1552244 0.515 rs67626468 chr3:10161518 C/A cg08888203 chr3:10149979 C3orf24 0.7 8.5 0.42 6.9e-16 Alzheimer's disease; CRC cis rs6772849 0.930 rs1962040 chr3:128324161 G/A cg08795948 chr3:128337044 NA 0.34 5.78 0.3 1.72e-8 Monocyte percentage of white cells;Monocyte count; CRC cis rs1801251 0.963 rs283481 chr2:233648091 A/G cg25237894 chr2:233734115 C2orf82 0.56 9.04 0.45 1.36e-17 Coronary artery disease; CRC cis rs9381040 1.000 rs9381040 chr6:41154650 C/T cg03644281 chr6:41068752 NFYA;LOC221442 -0.47 -6.35 -0.33 7.08e-10 Alzheimer's disease (late onset); CRC cis rs360798 0.553 rs7562734 chr2:63047973 G/C cg17519650 chr2:63277830 OTX1 -0.45 -6.34 -0.33 7.45e-10 Coronary artery disease; CRC cis rs7095944 0.584 rs4962692 chr10:126424823 G/A cg08799069 chr10:126477246 METTL10 -0.44 -6.78 -0.35 5.46e-11 Asthma; CRC cis rs941873 0.772 rs1892498 chr10:81103862 A/G cg09469691 chr10:81107165 PPIF 0.54 8.58 0.43 3.86e-16 Height; CRC cis rs9611565 0.546 rs132793 chr22:42063681 A/G cg06634786 chr22:41940651 POLR3H 0.56 6.1 0.32 2.92e-9 Vitiligo; CRC cis rs2573652 0.722 rs8041337 chr15:100541808 T/C cg00587665 chr15:100533223 ADAMTS17 -0.35 -6.18 -0.32 1.84e-9 Height; CRC cis rs780096 0.526 rs780102 chr2:27659491 T/C cg12648201 chr2:27665141 KRTCAP3 -0.32 -6.36 -0.33 6.91e-10 Total body bone mineral density; CRC trans rs10050311 0.698 rs78818211 chr4:87636388 C/T cg00004207 chr2:38977301 SFRS7 0.5 6.07 0.32 3.56e-9 Insulin-related traits; CRC cis rs10504229 0.639 rs56825757 chr8:58106469 A/G cg21724239 chr8:58056113 NA 0.52 6.99 0.36 1.58e-11 Developmental language disorder (linguistic errors); CRC cis rs10504229 0.683 rs55660024 chr8:58128943 G/A cg24829409 chr8:58192753 C8orf71 -0.55 -8.03 -0.4 1.71e-14 Developmental language disorder (linguistic errors); CRC cis rs612683 0.735 rs3754131 chr1:100931073 A/C cg06223162 chr1:101003688 GPR88 0.37 6.66 0.34 1.16e-10 Breast cancer; CRC cis rs4665809 0.887 rs4665814 chr2:26273687 G/T cg26119090 chr2:26468346 HADHA;HADHB -0.6 -7.93 -0.4 3.5e-14 Gut microbiome composition (summer); CRC cis rs4727027 0.933 rs4725800 chr7:148862516 C/G cg12479418 chr7:148823350 ZNF425;ZNF398 0.41 5.6 0.3 4.43e-8 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC cis rs2645694 0.626 rs2703124 chr4:77820626 G/T cg03477792 chr4:77819574 ANKRD56 0.44 6.37 0.33 6.51e-10 Emphysema distribution in smoking; CRC cis rs2996428 0.561 rs2275827 chr1:3746585 T/G cg22529645 chr1:3704559 LRRC47 0.43 5.81 0.3 1.5e-8 Red cell distribution width; CRC cis rs13315871 0.929 rs7634153 chr3:58237501 G/A cg20936604 chr3:58311152 NA -0.67 -6.76 -0.35 6.41e-11 Cholesterol, total; CRC cis rs7552404 0.731 rs7523573 chr1:76372020 G/T cg03433033 chr1:76189801 ACADM 0.73 8.83 0.44 6.36e-17 Blood metabolite levels;Acylcarnitine levels; CRC cis rs6582630 0.555 rs10880624 chr12:38526316 C/T cg13010199 chr12:38710504 ALG10B 0.49 6.54 0.34 2.31e-10 Drug-induced liver injury (flucloxacillin); CRC cis rs57221529 0.713 rs72703072 chr5:590626 A/G cg09021430 chr5:549028 NA -0.7 -7.75 -0.39 1.17e-13 Lung disease severity in cystic fibrosis; CRC cis rs10540 1.000 rs61876323 chr11:462855 G/A cg15790184 chr11:494944 RNH1 0.59 6.1 0.32 2.95e-9 Body mass index; CRC trans rs2228479 0.867 rs11646448 chr16:89966357 A/T cg24644049 chr4:85504048 CDS1 0.73 6.83 0.35 4.1e-11 Skin colour saturation; CRC cis rs6960043 0.905 rs10264723 chr7:15054370 T/C cg19272540 chr7:15055459 NA 0.24 6.61 0.34 1.59e-10 Type 2 diabetes; CRC cis rs7811142 0.720 rs112622797 chr7:99917416 G/A cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.89 10.76 0.51 2.39e-23 Platelet count; CRC cis rs12682352 0.602 rs635594 chr8:8613387 C/T cg06636001 chr8:8085503 FLJ10661 -0.57 -8.25 -0.41 3.89e-15 Neuroticism; CRC cis rs9467773 0.869 rs742090 chr6:26415637 A/C cg09904177 chr6:26538194 HMGN4 -0.67 -9.95 -0.48 1.41e-20 Intelligence (multi-trait analysis); CRC cis rs72627123 0.867 rs73303122 chr14:74486797 A/G cg12022184 chr14:74485813 ENTPD5;C14orf45 0.72 6.19 0.32 1.8e-9 Morning vs. evening chronotype; CRC cis rs7666738 0.830 rs2903152 chr4:99067992 A/G cg05340658 chr4:99064831 C4orf37 0.6 9.33 0.46 1.57e-18 Colonoscopy-negative controls vs population controls; CRC cis rs2032447 0.839 rs199750 chr6:26016462 A/G cg04800585 chr6:26043546 HIST1H2BB -0.58 -8.61 -0.43 3.07e-16 Intelligence (multi-trait analysis); CRC cis rs2882667 0.690 rs288036 chr5:138210895 C/A cg09476006 chr5:138032270 NA 0.54 8.92 0.44 3.21e-17 Age-related hearing impairment (SNP x SNP interaction); CRC trans rs3806843 0.808 rs6893708 chr5:140125922 T/C cg06840491 chr10:48416966 GDF2 -0.35 -6.07 -0.32 3.43e-9 Depressive symptoms (multi-trait analysis); CRC cis rs13191362 0.573 rs1877769 chr6:163252315 A/G cg21926612 chr6:163149169 PACRG;PARK2 0.52 7.29 0.37 2.31e-12 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg07892339 chr1:156721493 HDGF 0.44 6.17 0.32 2.04e-9 Response to antipsychotic treatment; CRC cis rs2302190 1.000 rs2302190 chr17:56584508 A/G cg12560992 chr17:57184187 TRIM37 0.5 6.33 0.33 8.19e-10 Vitamin D levels; CRC trans rs12432203 0.831 rs72622424 chr14:51730989 T/A cg14592830 chr9:122318704 NA 0.57 5.98 0.31 5.77e-9 Cancer; CRC cis rs4713118 0.869 rs9283882 chr6:27715258 A/C cg20933634 chr6:27740509 NA 0.59 8.66 0.43 2.1e-16 Parkinson's disease; CRC trans rs4332037 0.707 rs11763813 chr7:1896690 C/T cg11693508 chr17:37793320 STARD3 0.71 8.79 0.44 8.21e-17 Bipolar disorder; CRC cis rs17401966 1.000 rs35837142 chr1:10322358 C/G cg19773385 chr1:10388646 KIF1B -0.58 -8.15 -0.41 7.49e-15 Hepatocellular carcinoma; CRC cis rs9910055 1.000 rs9895423 chr17:42285740 T/C cg19774624 chr17:42201019 HDAC5 -0.65 -9.58 -0.47 2.46e-19 Total body bone mineral density; CRC cis rs1046896 0.552 rs12602280 chr17:80805421 G/C cg02711726 chr17:80685570 FN3KRP -0.54 -7.12 -0.37 6.84e-12 Glycated hemoglobin levels; CRC cis rs9916302 0.861 rs3889368 chr17:37683231 C/T cg15445000 chr17:37608096 MED1 0.41 8.87 0.44 4.63e-17 Glomerular filtration rate (creatinine); CRC cis rs763014 1.000 rs763014 chr16:675680 T/C cg00908189 chr16:619842 PIGQ 0.67 10.98 0.52 4.14e-24 Height; CRC cis rs2836974 0.836 rs1041440 chr21:40627325 C/T cg11890956 chr21:40555474 PSMG1 1.11 19.31 0.73 4.39e-56 Cognitive function; CRC cis rs1799949 0.965 rs33925201 chr17:41280682 A/G cg19454999 chr17:41278357 BRCA1;NBR2 0.54 8.54 0.43 5.2e-16 Menopause (age at onset); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg20349076 chr11:118992192 HINFP 0.4 6.49 0.34 3.16e-10 Liver disease severity in Alagille syndrome; CRC cis rs3820068 0.581 rs16849152 chr1:15921774 A/C cg13390004 chr1:15929781 NA 0.49 7.0 0.36 1.45e-11 Systolic blood pressure; CRC cis rs7666738 0.830 rs1834645 chr4:98979593 T/A cg05340658 chr4:99064831 C4orf37 0.6 9.41 0.46 8.81e-19 Colonoscopy-negative controls vs population controls; CRC cis rs6558530 0.640 rs7844748 chr8:1702343 C/T cg19131313 chr8:1704013 NA 0.49 5.92 0.31 8.27e-9 Systolic blood pressure; CRC cis rs6570726 0.791 rs11155426 chr6:145817130 T/C cg23711669 chr6:146136114 FBXO30 0.75 13.0 0.58 1.81e-31 Lobe attachment (rater-scored or self-reported); CRC cis rs4629180 0.593 rs6707517 chr2:102089878 C/T cg04415270 chr2:102091202 RFX8 -0.6 -8.61 -0.43 3.16e-16 Chronic rhinosinusitis with nasal polyps; CRC cis rs8072100 0.817 rs11869940 chr17:45578435 T/A cg08085267 chr17:45401833 C17orf57 0.65 10.67 0.51 4.95e-23 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs9322193 0.962 rs9765929 chr6:150090816 T/C cg07701084 chr6:150067640 NUP43 0.46 6.49 0.34 3.1e-10 Lung cancer; CRC cis rs710865 0.519 rs3748759 chr1:19487656 C/T cg13387374 chr1:19411106 UBR4 -0.47 -7.4 -0.38 1.13e-12 Brain structure; CRC cis rs9911578 0.967 rs2429369 chr17:56501420 A/G cg12560992 chr17:57184187 TRIM37 0.86 14.73 0.63 4.66e-38 Intelligence (multi-trait analysis); CRC cis rs5753618 0.607 rs5753621 chr22:31847647 T/C cg07713946 chr22:31675144 LIMK2 0.38 5.89 0.31 9.68e-9 Colorectal cancer; CRC cis rs67311347 1.000 rs17078813 chr3:40434162 C/T cg09455208 chr3:40491958 NA 0.5 9.9 0.48 2.19e-20 Renal cell carcinoma; CRC cis rs10791097 0.748 rs4937580 chr11:130734270 T/C cg12179176 chr11:130786555 SNX19 0.72 12.18 0.56 1.96e-28 Autism spectrum disorder or schizophrenia;Schizophrenia; CRC cis rs7208859 0.623 rs216445 chr17:28933576 A/G cg13385521 chr17:29058706 SUZ12P 0.58 6.35 0.33 7.04e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs9911578 1.000 rs7215808 chr17:56940742 G/C cg12560992 chr17:57184187 TRIM37 0.92 16.95 0.68 9.27e-47 Intelligence (multi-trait analysis); CRC cis rs9487051 0.735 rs351754 chr6:109537553 A/G cg21918786 chr6:109611834 NA 0.36 6.29 0.33 1.03e-9 Reticulocyte fraction of red cells; CRC cis rs6032067 0.929 rs17333555 chr20:43809761 C/T cg10761708 chr20:43804764 PI3 0.44 5.66 0.3 3.38e-8 Blood protein levels; CRC cis rs6502050 0.835 rs10163483 chr17:80110396 C/A cg25804541 chr17:80189381 SLC16A3 -0.31 -5.97 -0.31 6.08e-9 Life satisfaction; CRC cis rs2985684 0.948 rs12886130 chr14:50082753 T/C cg23565292 chr14:50234668 KLHDC2 -0.42 -5.83 -0.31 1.3e-8 Carotid intima media thickness; CRC cis rs8180040 0.726 rs1869869 chr3:47027833 G/A cg02527881 chr3:46936655 PTH1R -0.4 -7.28 -0.37 2.5e-12 Colorectal cancer; CRC trans rs35110281 0.755 rs4819270 chr21:45020919 G/A cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.51 8.46 0.42 8.99e-16 Mean corpuscular volume; CRC cis rs3820068 0.608 rs12092485 chr1:16048038 A/G cg27534772 chr1:16042836 PLEKHM2 0.54 10.28 0.49 1.13e-21 Systolic blood pressure; CRC cis rs8077889 0.871 rs8081101 chr17:41904332 C/T cg16892393 chr17:41919603 NA 0.49 7.55 0.38 4.32e-13 Triglycerides; CRC cis rs12612619 0.732 rs6547401 chr2:27284845 A/G cg00617064 chr2:27272375 NA -0.37 -6.17 -0.32 1.97e-9 Venous thromboembolism adjusted for sickle cell variant rs77121243-T; CRC cis rs6429082 0.509 rs2789362 chr1:235521235 A/G cg26050004 chr1:235667680 B3GALNT2 0.46 6.72 0.35 7.81e-11 Adiposity; CRC cis rs10760158 0.832 rs10760171 chr9:124058359 C/T cg14417974 chr9:124058376 GSN -0.34 -5.75 -0.3 2.04e-8 Pulse pressure; CRC cis rs2645694 0.626 rs2703115 chr4:77824442 C/T cg18351406 chr4:77819688 ANKRD56 0.51 7.96 0.4 2.86e-14 Emphysema distribution in smoking; CRC cis rs7552404 0.690 rs7549863 chr1:76327923 T/C cg22875332 chr1:76189707 ACADM -0.53 -6.91 -0.36 2.5e-11 Blood metabolite levels;Acylcarnitine levels; CRC cis rs10512697 0.803 rs1867709 chr5:3576091 C/A cg19473799 chr5:3511975 NA -0.72 -5.67 -0.3 3.12e-8 Immune response to smallpox vaccine (IL-6); CRC cis rs13064411 0.696 rs6773497 chr3:113186514 T/C cg10517650 chr3:113235015 CCDC52 -0.37 -6.49 -0.34 3.16e-10 Response to simvastatin treatment (PCSK9 protein level change); CRC cis rs6582630 0.555 rs34145279 chr12:38405588 T/C cg13010199 chr12:38710504 ALG10B 0.45 5.72 0.3 2.42e-8 Drug-induced liver injury (flucloxacillin); CRC trans rs8073060 0.521 rs225254 chr17:33953384 G/A cg19694781 chr19:47549865 TMEM160 -0.46 -7.3 -0.37 2.14e-12 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; CRC cis rs7786808 0.608 rs6978352 chr7:158209802 T/C cg09998033 chr7:158218633 PTPRN2 0.49 6.88 0.35 2.99e-11 Obesity-related traits; CRC cis rs1552244 0.554 rs2272118 chr3:10049287 T/C cg02579736 chr3:10068473 FANCD2;CIDECP 0.68 9.51 0.46 4.18e-19 Alzheimer's disease; CRC cis rs9911578 0.902 rs12948746 chr17:57071892 A/G cg12560992 chr17:57184187 TRIM37 0.94 17.29 0.69 4.4e-48 Intelligence (multi-trait analysis); CRC cis rs1799949 0.965 rs11658499 chr17:41334749 C/T cg25072359 chr17:41440525 NA 0.44 6.49 0.34 3.23e-10 Menopause (age at onset); CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg02924619 chr14:65007171 HSPA2 0.47 6.34 0.33 7.66e-10 Anxiety disorder; CRC cis rs1218582 0.772 rs6686873 chr1:154913404 C/G cg16680214 chr1:154839983 KCNN3 -0.45 -8.9 -0.44 3.9e-17 Prostate cancer; CRC cis rs72615157 0.664 rs6953580 chr7:99825275 A/G cg13153964 chr7:100026424 MEPCE;ZCWPW1 0.8 9.86 0.48 2.95e-20 Lung function (FEV1/FVC); CRC cis rs11190604 1.000 rs57025426 chr10:102205868 A/G cg07570687 chr10:102243282 WNT8B 0.44 5.64 0.3 3.61e-8 Palmitoleic acid (16:1n-7) levels; CRC cis rs7772486 0.817 rs9386145 chr6:146363519 A/T cg05347473 chr6:146136440 FBXO30 0.37 5.89 0.31 9.38e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs921968 0.565 rs2272189 chr2:219610322 G/A cg02176678 chr2:219576539 TTLL4 -0.43 -6.77 -0.35 5.94e-11 Mean corpuscular hemoglobin concentration; CRC cis rs6942756 1.000 rs6942756 chr7:128886821 T/G cg02491457 chr7:128862824 NA -0.77 -10.45 -0.5 2.96e-22 White matter hyperintensity burden; CRC cis rs9303401 0.659 rs12952325 chr17:56899371 G/A cg02118635 chr17:56770003 RAD51C;TEX14 0.77 9.98 0.48 1.15e-20 Cognitive test performance; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg00300664 chr10:65224816 JMJD1C;LOC84989 0.46 6.45 0.34 4.03e-10 Response to antipsychotic treatment; CRC cis rs6840360 1.000 rs3749561 chr4:152610117 C/T cg09659197 chr4:152720779 NA -0.49 -10.63 -0.51 6.74e-23 Intelligence (multi-trait analysis); CRC cis rs9847710 0.791 rs6808387 chr3:53079732 C/T cg04503182 chr3:53078218 SFMBT1 -0.45 -7.15 -0.37 5.55e-12 Ulcerative colitis; CRC cis rs2576037 0.501 rs7227700 chr18:44537102 T/G cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.68 -10.74 -0.51 2.83e-23 Personality dimensions; CRC cis rs2816062 0.760 rs2244192 chr1:18890939 A/T cg18795169 chr1:18902165 NA -0.92 -19.11 -0.73 2.74e-55 Urate levels in lean individuals; CRC cis rs832540 0.966 rs33321 chr5:56206073 G/T cg18230493 chr5:56204884 C5orf35 -0.38 -5.64 -0.3 3.57e-8 Coronary artery disease; CRC cis rs6933660 0.760 rs3806982 chr6:151774916 G/A cg10883421 chr6:151773342 RMND1;C6orf211 0.76 13.7 0.6 4.21e-34 Menarche (age at onset); CRC cis rs6930083 0.737 rs13196885 chr6:36632688 C/T cg08179530 chr6:36648295 CDKN1A -0.64 -10.05 -0.48 6.88e-21 Coronary artery disease; CRC cis rs926938 0.563 rs360652 chr1:115445478 C/T cg12756093 chr1:115239321 AMPD1 0.56 8.32 0.42 2.42e-15 Autism; CRC cis rs9381040 0.610 rs9357345 chr6:41025118 G/C cg03644281 chr6:41068752 NFYA;LOC221442 -0.44 -6.33 -0.33 8.04e-10 Alzheimer's disease (late onset); CRC cis rs734999 0.545 rs28568531 chr1:2555640 T/A cg20673091 chr1:2541236 MMEL1 0.38 6.14 0.32 2.4e-9 Ulcerative colitis; CRC cis rs7772486 0.875 rs865913 chr6:146308874 C/T cg13319975 chr6:146136371 FBXO30 -0.39 -5.87 -0.31 1.08e-8 Lobe attachment (rater-scored or self-reported); CRC cis rs3757247 0.729 rs4706361 chr6:90915910 T/C cg06866423 chr6:90926672 BACH2 0.47 8.07 0.41 1.34e-14 Vitiligo;Type 1 diabetes; CRC cis rs9747201 1.000 rs9303020 chr17:80163247 C/T cg09264619 chr17:80180166 NA -0.51 -7.35 -0.38 1.55e-12 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs13108904 0.905 rs1732108 chr4:1276550 C/T cg16405210 chr4:1374714 KIAA1530 0.42 5.98 0.31 5.89e-9 Obesity-related traits; CRC cis rs637571 0.512 rs660118 chr11:65735174 G/C cg26695010 chr11:65641043 EFEMP2 -0.4 -5.76 -0.3 1.89e-8 Eosinophil percentage of white cells; CRC cis rs823143 0.570 rs1361754 chr1:205801872 C/T cg26354017 chr1:205819088 PM20D1 -0.63 -9.91 -0.48 2.05e-20 Monocyte percentage of white cells; CRC cis rs1580019 0.563 rs764483 chr7:32578150 A/T cg07520158 chr7:32535189 LSM5;AVL9 0.54 7.91 0.4 3.83e-14 Cognitive ability; CRC cis rs7772486 0.754 rs1415747 chr6:146077249 A/G cg23711669 chr6:146136114 FBXO30 0.73 12.35 0.56 4.83e-29 Lobe attachment (rater-scored or self-reported); CRC cis rs2688482 0.557 rs3103952 chr3:195522690 T/C cg13752114 chr3:195489708 MUC4 0.77 8.71 0.43 1.45e-16 Lung disease severity in cystic fibrosis; CRC cis rs4481887 0.893 rs28451623 chr1:248509783 G/A cg13385794 chr1:248469461 NA 0.34 6.18 0.32 1.86e-9 Common traits (Other); CRC trans rs7395662 1.000 rs12421159 chr11:48624841 C/A cg21153622 chr11:89784906 NA -0.44 -7.09 -0.36 8.32e-12 HDL cholesterol; CRC cis rs12913538 0.755 rs12915312 chr15:62895475 G/C cg09983546 chr15:62884068 NA 0.46 6.2 0.32 1.67e-9 Sleep depth; CRC cis rs10227331 1.000 rs10227331 chr7:157294938 A/T cg04156418 chr7:157293606 NA 0.34 6.14 0.32 2.42e-9 Inattentive symptoms; CRC cis rs4604732 0.578 rs79203328 chr1:247626581 C/G cg12758973 chr1:247694275 LOC148824;OR2C3 0.42 6.14 0.32 2.32e-9 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CRC cis rs612683 0.764 rs558035 chr1:100939777 T/C cg06223162 chr1:101003688 GPR88 -0.31 -5.72 -0.3 2.34e-8 Breast cancer; CRC cis rs3617 0.559 rs11915546 chr3:52866845 A/C cg11645453 chr3:52864694 ITIH4 -0.46 -9.14 -0.45 6.83e-18 Red blood cell count;Autism spectrum disorder or schizophrenia; CRC cis rs7786877 0.508 rs11765509 chr7:100310990 T/G cg00334542 chr7:100209784 MOSPD3 -0.55 -7.09 -0.36 8.04e-12 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs4853012 0.838 rs4563249 chr2:74354016 G/T cg19729930 chr2:74357872 NA 0.67 10.5 0.5 1.9e-22 Gestational age at birth (maternal effect); CRC cis rs7274811 0.744 rs55651102 chr20:32188068 A/T cg07470512 chr20:32255052 NECAB3;C20orf134 -0.45 -5.95 -0.31 6.98e-9 Height; CRC cis rs1005277 0.505 rs7099777 chr10:38183569 A/C cg25517755 chr10:38738941 LOC399744 0.45 6.57 0.34 1.93e-10 Extrinsic epigenetic age acceleration; CRC cis rs9487051 0.676 rs4383852 chr6:109594475 G/A cg12927641 chr6:109611667 NA -0.37 -6.61 -0.34 1.52e-10 Reticulocyte fraction of red cells; CRC cis rs514406 0.698 rs522259 chr1:53365481 A/G cg25767906 chr1:53392781 SCP2 -0.5 -7.68 -0.39 1.89e-13 Monocyte count; CRC cis rs2380220 0.516 rs7748108 chr6:96008082 T/C cg07718321 chr6:96025334 MANEA 0.44 5.97 0.31 6.19e-9 Behavioural disinhibition (generation interaction); CRC cis rs9549367 0.713 rs3024757 chr13:113823186 G/T cg18105134 chr13:113819100 PROZ -0.84 -12.29 -0.56 8.14e-29 Platelet distribution width; CRC cis rs13256369 1.000 rs10110591 chr8:8576608 G/T cg06636001 chr8:8085503 FLJ10661 -0.51 -6.96 -0.36 1.9e-11 Obesity-related traits; CRC cis rs734999 0.545 rs6666788 chr1:2567500 A/G cg20673091 chr1:2541236 MMEL1 -0.36 -5.74 -0.3 2.15e-8 Ulcerative colitis; CRC cis rs4363385 0.679 rs6686286 chr1:152984562 T/C cg25856811 chr1:152973957 SPRR3 -0.26 -7.09 -0.36 8.28e-12 Inflammatory skin disease; CRC cis rs17376456 0.825 rs13361613 chr5:93272176 C/T cg25358565 chr5:93447407 FAM172A 1.1 10.9 0.52 7.71e-24 Diabetic retinopathy; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg01708236 chr6:44233446 NFKBIE 0.39 6.04 0.32 4.19e-9 Liver disease severity in Alagille syndrome; CRC cis rs4665809 0.589 rs4665841 chr2:26448950 G/A cg22920501 chr2:26401640 FAM59B -0.83 -12.27 -0.56 9.4e-29 Gut microbiome composition (summer); CRC cis rs9467773 0.620 rs9461276 chr6:26595168 T/C cg09904177 chr6:26538194 HMGN4 0.73 11.54 0.54 4.38e-26 Intelligence (multi-trait analysis); CRC trans rs8073060 0.586 rs225256 chr17:33955756 C/T cg19694781 chr19:47549865 TMEM160 -1.05 -14.7 -0.63 5.76e-38 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; CRC cis rs6740322 0.857 rs11690012 chr2:43542480 C/G cg06169590 chr2:43455088 ZFP36L2;LOC100129726 -0.52 -6.56 -0.34 2.03e-10 Coronary artery disease; CRC cis rs11677416 1.000 rs1516790 chr2:113531291 G/A cg27083787 chr2:113543245 IL1A 0.46 6.59 0.34 1.76e-10 Response to antipsychotic treatment in schizophrenia (working memory); CRC cis rs7666738 0.888 rs13110683 chr4:98983368 G/C cg17366294 chr4:99064904 C4orf37 0.45 7.31 0.37 2.08e-12 Colonoscopy-negative controls vs population controls; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg11913218 chr1:10754156 CASZ1 0.37 6.49 0.34 3.22e-10 Liver disease severity in Alagille syndrome; CRC cis rs79839061 0.610 rs62297087 chr4:913289 T/A cg14530993 chr4:882597 GAK 0.8 7.51 0.38 5.67e-13 Intelligence (multi-trait analysis); CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg13674574 chr14:64971270 ZBTB25;ZBTB1 0.43 6.1 0.32 2.97e-9 Anxiety disorder; CRC cis rs4665809 0.590 rs13019536 chr2:26526978 C/A cg04944784 chr2:26401820 FAM59B -0.59 -7.51 -0.38 5.75e-13 Gut microbiome composition (summer); CRC cis rs6951245 0.638 rs4720486 chr7:1146764 G/A cg26224354 chr7:1096374 C7orf50;GPR146 -0.62 -8.34 -0.42 1.99e-15 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs13108904 0.967 rs1316419 chr4:1293997 C/T cg02018176 chr4:1364513 KIAA1530 0.47 7.7 0.39 1.5700000000000001e-13 Obesity-related traits; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg22998610 chr11:62538411 TAF6L 0.4 6.43 0.33 4.38e-10 Liver disease severity in Alagille syndrome; CRC cis rs7727544 0.716 rs11955347 chr5:131567924 G/A cg12564285 chr5:131593104 PDLIM4 0.4 7.61 0.39 2.92e-13 Blood metabolite levels; CRC cis rs7773004 0.905 rs6932727 chr6:26327087 C/A cg13736514 chr6:26305472 NA -0.36 -6.17 -0.32 1.99e-9 Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for body mass index;Waist circumference adjusted for BMI in non-smokers;Waist circumference adjusted for BMI (adjusted for smoking behaviour); CRC trans rs1455244 0.700 rs7229302 chr18:11508904 G/T cg07005090 chr11:59522827 STX3 0.38 5.98 0.31 5.78e-9 Schizophrenia; CRC cis rs10504229 0.683 rs11774847 chr8:58140775 T/A cg08219700 chr8:58056026 NA 0.56 6.58 0.34 1.91e-10 Developmental language disorder (linguistic errors); CRC cis rs1707322 1.000 rs785507 chr1:46541558 C/T cg06784218 chr1:46089804 CCDC17 -0.6 -10.05 -0.48 6.89e-21 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs3862030 0.503 rs6584505 chr10:104254412 C/A cg22532475 chr10:104410764 TRIM8 -0.36 -6.58 -0.34 1.9e-10 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for body mass index; CRC cis rs780096 0.506 rs56076827 chr2:27676287 A/T cg21248554 chr2:27665150 KRTCAP3 -0.33 -7.3 -0.37 2.24e-12 Total body bone mineral density; CRC cis rs9308731 0.966 rs4849442 chr2:111934219 C/T cg04202892 chr2:111875749 ACOXL 0.36 5.72 0.3 2.43e-8 Chronic lymphocytic leukemia; CRC cis rs7618501 0.571 rs2240329 chr3:50107512 G/A cg24308560 chr3:49941425 MST1R 0.53 8.91 0.44 3.55e-17 Intelligence (multi-trait analysis); CRC cis rs76878669 0.561 rs12420203 chr11:66163794 T/C cg24851651 chr11:66362959 CCS -0.39 -6.86 -0.35 3.45e-11 Educational attainment (years of education); CRC trans rs617791 0.530 rs10896073 chr11:65762814 T/C cg17712092 chr4:129076599 LARP1B -0.46 -6.69 -0.35 9.65e-11 Breast cancer; CRC cis rs9914988 0.943 rs4795465 chr17:27151498 A/G cg12682573 chr17:27188876 MIR451;MIR144 -0.57 -7.89 -0.4 4.43e-14 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs7223966 1.000 rs8075521 chr17:61804954 C/T cg23090583 chr17:61904693 PSMC5;FTSJ3 0.5 6.18 0.32 1.89e-9 Hip circumference adjusted for BMI;Body mass index; CRC cis rs7429990 0.965 rs7651237 chr3:48105528 A/G cg11946769 chr3:48343235 NME6 -0.58 -6.88 -0.35 2.99e-11 Educational attainment (years of education); CRC cis rs11227306 0.934 rs7940691 chr11:65640906 C/T cg26695010 chr11:65641043 EFEMP2 0.41 5.97 0.31 6.06e-9 DNA methylation (variation); CRC cis rs853679 0.517 rs35512245 chr6:28079953 T/C cg12963246 chr6:28129442 ZNF389 0.5 5.82 0.31 1.38e-8 Depression; CRC cis rs10540 1.000 rs12421457 chr11:505780 T/C cg19913688 chr11:428466 ANO9 -0.7 -7.19 -0.37 4.26e-12 Body mass index; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg22924680 chr5:43557135 PAIP1 0.36 5.98 0.31 5.72e-9 Liver disease severity in Alagille syndrome; CRC cis rs1552244 0.572 rs41464050 chr3:10158393 A/G cg10729496 chr3:10149963 C3orf24 0.49 5.77 0.3 1.83e-8 Alzheimer's disease; CRC trans rs4276421 0.776 rs7717787 chr5:45466616 C/G cg04793272 chr11:119020941 ABCG4 -0.4 -6.57 -0.34 1.95e-10 P wave duration; CRC cis rs9302690 1.000 rs9302690 chr16:57442968 G/A cg27017172 chr16:57497170 POLR2C 0.58 5.99 0.31 5.42e-9 Blood protein levels; CRC cis rs1580019 0.587 rs7805311 chr7:32558302 A/G cg06627557 chr7:32535165 LSM5;AVL9 -0.97 -18.38 -0.71 2.06e-52 Cognitive ability; CRC cis rs6681460 1.000 rs7524818 chr1:67072031 C/T cg02459107 chr1:67143332 SGIP1 0.45 7.84 0.4 6.45e-14 Presence of antiphospholipid antibodies; CRC cis rs2456568 0.548 rs6483280 chr11:93661592 T/C cg26875233 chr11:93583750 C11orf90 -0.36 -6.82 -0.35 4.24e-11 Response to serotonin reuptake inhibitors in major depressive disorder; CRC cis rs6540556 0.723 rs12060420 chr1:209906819 T/G cg05527609 chr1:210001259 C1orf107 -0.57 -6.34 -0.33 7.45e-10 Red blood cell count; CRC cis rs875971 0.895 rs4145009 chr7:65726615 T/C cg18252515 chr7:66147081 NA 0.4 5.8 0.3 1.57e-8 Aortic root size; CRC trans rs2727020 0.636 rs10839275 chr11:49438962 T/A cg11707556 chr5:10655725 ANKRD33B -0.39 -7.31 -0.37 1.99e-12 Coronary artery disease; CRC cis rs7927592 0.673 rs498782 chr11:68275851 A/G cg01657329 chr11:68192670 LRP5 -0.56 -9.22 -0.45 3.72e-18 Total body bone mineral density; CRC cis rs7552404 0.961 rs1767458 chr1:76219155 A/G cg10523679 chr1:76189770 ACADM 0.77 11.71 0.54 1.07e-26 Blood metabolite levels;Acylcarnitine levels; CRC cis rs270601 0.633 rs733300 chr5:131572243 A/G cg20512303 chr5:131592959 PDLIM4 0.41 7.21 0.37 3.95e-12 Acylcarnitine levels; CRC cis rs2180341 0.960 rs9398842 chr6:127674662 T/C cg27446573 chr6:127587934 RNF146 0.93 13.48 0.6 2.71e-33 Breast cancer; CRC cis rs473651 0.740 rs502349 chr2:239318389 C/T cg08773314 chr2:239334832 ASB1 0.36 7.99 0.4 2.28e-14 Multiple system atrophy; CRC cis rs10927875 0.541 rs1763596 chr1:16343835 C/T cg24140574 chr1:16342155 HSPB7 0.47 6.65 0.34 1.19e-10 Dilated cardiomyopathy; CRC trans rs1390943 1.000 rs13253777 chr8:20071770 C/G cg13714271 chr9:33076774 SMU1 -0.45 -6.24 -0.33 1.32e-9 Circulating myeloperoxidase levels (serum); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg05422897 chr2:113403145 SLC20A1 0.45 6.16 0.32 2.07e-9 Response to antipsychotic treatment; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg16484842 chr20:57556086 TH1L 0.46 6.74 0.35 7.04e-11 Intelligence (multi-trait analysis); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg18759346 chr3:149470375 COMMD2 0.43 6.06 0.32 3.71e-9 Response to antipsychotic treatment; CRC trans rs7395662 0.963 rs2135680 chr11:48728425 T/C cg21153622 chr11:89784906 NA -0.48 -7.72 -0.39 1.45e-13 HDL cholesterol; CRC cis rs7677751 0.806 rs7673027 chr4:55096180 T/A cg17187183 chr4:55093834 PDGFRA 0.52 7.68 0.39 1.82e-13 Corneal astigmatism; CRC trans rs4698169 0.510 rs675984 chr4:17123821 A/G cg09883849 chr7:12510863 NA 0.69 5.98 0.31 5.74e-9 Temperament (bipolar disorder); CRC cis rs6142102 0.961 rs2377957 chr20:32554473 A/G cg08999081 chr20:33150536 PIGU 0.4 6.18 0.32 1.94e-9 Skin pigmentation; CRC cis rs798554 0.759 rs2644309 chr7:2889034 T/C cg19717773 chr7:2847554 GNA12 -0.49 -6.72 -0.35 8.1e-11 Height; CRC cis rs7633770 0.769 rs3796371 chr3:46667224 C/T cg11219411 chr3:46661640 NA 0.74 13.05 0.58 1.14e-31 Coronary artery disease; CRC cis rs35110281 0.744 rs162398 chr21:44949285 T/C cg04455712 chr21:45112962 RRP1B 0.41 7.91 0.4 4.04e-14 Mean corpuscular volume; CRC cis rs713587 0.713 rs12466350 chr2:25239969 A/G cg22495460 chr2:25135724 ADCY3 -0.67 -11.27 -0.53 4.04e-25 Body mass index in non-asthmatics; CRC cis rs4822044 0.680 rs8138780 chr22:42097462 A/T cg06634786 chr22:41940651 POLR3H 0.63 7.14 0.37 5.98e-12 Cannabis dependence symptom count; CRC cis rs16858210 0.618 rs6794500 chr3:183620769 A/G cg25686905 chr3:183603175 PARL -0.47 -5.83 -0.31 1.34e-8 Menopause (age at onset); CRC cis rs11764590 0.694 rs60626033 chr7:2099719 A/G cg23422044 chr7:1970798 MAD1L1 -0.41 -5.67 -0.3 3.07e-8 Neuroticism; CRC cis rs10504229 0.593 rs79874994 chr8:57993709 C/A cg22535103 chr8:58192502 C8orf71 -0.63 -6.63 -0.34 1.38e-10 Developmental language disorder (linguistic errors); CRC cis rs62432291 0.681 rs3003174 chr6:159655326 T/C cg14500486 chr6:159655392 FNDC1 -0.76 -10.4 -0.5 4.17e-22 Joint mobility (Beighton score); CRC cis rs6964587 1.000 rs6465347 chr7:91693837 A/G cg17063962 chr7:91808500 NA 0.8 14.02 0.61 2.36e-35 Breast cancer; CRC cis rs28386778 0.897 rs2584635 chr17:61865934 A/G cg25654072 chr17:61904446 PSMC5;FTSJ3 0.74 11.57 0.54 3.23e-26 Prudent dietary pattern; CRC cis rs826838 0.654 rs7977738 chr12:38722460 G/A cg26384229 chr12:38710491 ALG10B 0.54 8.17 0.41 6.9e-15 Heart rate; CRC cis rs6963495 0.674 rs75880756 chr7:105163821 G/C cg13798780 chr7:105162888 PUS7 0.68 8.08 0.41 1.27e-14 Bipolar disorder (body mass index interaction); CRC cis rs826838 1.000 rs10875991 chr12:39108886 G/C cg13010199 chr12:38710504 ALG10B 0.45 5.89 0.31 9.73e-9 Heart rate; CRC cis rs4819052 0.851 rs2838836 chr21:46665875 G/T cg19498844 chr21:46707878 POFUT2;LOC642852 0.77 11.12 0.52 1.33e-24 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs6598955 0.670 rs7522905 chr1:26609259 C/T cg00852783 chr1:26633632 UBXN11 0.43 6.99 0.36 1.58e-11 Obesity-related traits; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg25441200 chr7:156742235 NOM1 0.49 6.4 0.33 5.47e-10 Thyroid stimulating hormone; CRC cis rs12760731 0.545 rs34112873 chr1:178519943 C/T cg00404053 chr1:178313656 RASAL2 0.64 7.3 0.37 2.24e-12 Obesity-related traits; CRC cis rs4665809 1.000 rs4665306 chr2:26319124 C/T cg25036284 chr2:26402008 FAM59B -0.46 -6.03 -0.32 4.3e-9 Gut microbiome composition (summer); CRC cis rs8180040 1.000 rs295442 chr3:47335881 A/C cg10298567 chr3:47292165 KIF9 -0.42 -6.93 -0.36 2.16e-11 Colorectal cancer; CRC cis rs1570884 0.890 rs6561541 chr13:50127280 C/T cg03651054 chr13:50194643 NA 0.29 5.64 0.3 3.7e-8 Sum basophil neutrophil counts;Sum neutrophil eosinophil counts;Neutrophil count;Myeloid white cell count;Granulocyte count; CRC cis rs2046867 0.818 rs6789061 chr3:72888690 C/T cg25664220 chr3:72788482 NA -0.48 -6.7 -0.35 8.81e-11 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; CRC cis rs926392 0.572 rs6129157 chr20:37672247 G/T cg16355469 chr20:37678765 NA 0.49 7.3 0.37 2.23e-12 Dialysis-related mortality; CRC cis rs728616 0.681 rs11815284 chr10:82023142 G/T cg05935833 chr10:81318306 SFTPA2 -0.47 -6.28 -0.33 1.08e-9 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs4665809 0.627 rs7562192 chr2:26469457 C/G cg27170947 chr2:26402098 FAM59B 0.64 8.64 0.43 2.44e-16 Gut microbiome composition (summer); CRC cis rs9814567 1.000 rs4417907 chr3:134291363 C/T cg06541857 chr3:134203789 ANAPC13;CEP63 -0.4 -6.08 -0.32 3.39e-9 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs3018066 0.720 rs55633564 chr4:106981560 G/T cg01869342 chr4:106983673 TBCK 0.46 6.83 0.35 4.1e-11 Cancer; CRC cis rs2014572 0.967 rs10418480 chr19:57755055 C/T cg24459738 chr19:57751996 ZNF805 -0.53 -8.3 -0.42 2.68e-15 Hyperactive-impulsive symptoms; CRC cis rs1129187 0.755 rs13215983 chr6:42924193 C/T cg02353165 chr6:42928485 GNMT 0.72 12.11 0.56 3.75e-28 Alzheimer's disease in APOE e4+ carriers; CRC cis rs716595 0.786 rs10509912 chr10:112029405 T/A cg19584136 chr10:111975951 MXI1 -0.56 -6.13 -0.32 2.56e-9 Normalized brain volume; CRC cis rs12144094 1.000 rs12139860 chr1:120262848 G/T cg20995928 chr1:120229863 NA 0.48 5.86 0.31 1.11e-8 Height; CRC trans rs10982213 0.830 rs2274163 chr9:117188714 C/T cg25420398 chr3:133968920 RYK 0.41 6.38 0.33 6.1e-10 Interleukin-6 levels; CRC cis rs10512697 0.803 rs34007257 chr5:3576503 C/T cg19473799 chr5:3511975 NA -0.73 -5.72 -0.3 2.34e-8 Immune response to smallpox vaccine (IL-6); CRC cis rs12701220 0.895 rs10262866 chr7:1019536 G/A cg00990874 chr7:1149470 C7orf50 -0.54 -6.19 -0.32 1.79e-9 Bronchopulmonary dysplasia; CRC cis rs2836974 0.965 rs6517538 chr21:40656242 C/T cg06238570 chr21:40685208 BRWD1 0.79 10.86 0.51 1.11e-23 Cognitive function; CRC cis rs3858526 0.920 rs11039548 chr11:5930283 G/A cg05234568 chr11:5960015 NA -0.56 -7.76 -0.39 1.1e-13 DNA methylation (variation); CRC cis rs8032158 0.963 rs56333939 chr15:56124535 T/C cg02198044 chr15:56286336 NEDD4 -0.39 -6.0 -0.31 5.12e-9 Keloid; CRC cis rs9420 0.961 rs7949841 chr11:57524700 G/C cg23127183 chr11:57508653 C11orf31 -0.53 -7.17 -0.37 4.95e-12 Schizophrenia; CRC cis rs644799 0.965 rs2950522 chr11:95524719 C/T cg25622487 chr11:95524042 FAM76B;CEP57 0.75 11.84 0.55 3.59e-27 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs2051211 0.947 rs60479981 chr3:38568611 C/T cg01465620 chr3:38496096 LOC100128640;ACVR2B -0.46 -5.77 -0.3 1.87e-8 QRS duration; CRC trans rs11098499 1.000 rs10029750 chr4:120172543 A/G cg25214090 chr10:38739885 LOC399744 0.51 7.86 0.4 5.46e-14 Corneal astigmatism; CRC cis rs12188164 0.515 rs11744936 chr5:412112 C/T cg16322479 chr5:444228 EXOC3;C5orf55 0.37 5.71 0.3 2.58e-8 Cystic fibrosis severity; CRC cis rs7208859 0.673 rs11656462 chr17:29160700 G/A cg13385521 chr17:29058706 SUZ12P 0.64 7.64 0.39 2.42e-13 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC trans rs1728785 0.748 rs889560 chr16:68605784 A/G cg04657470 chr2:198365150 HSPE1;HSPD1 0.59 7.14 0.37 6.11e-12 Ulcerative colitis; CRC cis rs10540 0.841 rs35601764 chr11:532923 A/C cg19913688 chr11:428466 ANO9 -0.65 -6.58 -0.34 1.83e-10 Body mass index; CRC cis rs10489202 0.634 rs6427119 chr1:168074145 A/G cg24449463 chr1:168025552 DCAF6 0.49 6.89 0.36 2.86e-11 Schizophrenia; CRC cis rs2836974 0.623 rs34240248 chr21:40685239 A/G cg11644478 chr21:40555479 PSMG1 -0.66 -10.06 -0.48 6.31e-21 Cognitive function; CRC cis rs736801 0.754 rs2706336 chr5:131799961 T/C cg21138405 chr5:131827807 IRF1 0.35 6.03 0.32 4.33e-9 Breast cancer;Mosquito bite size; CRC cis rs8180040 0.966 rs6792488 chr3:47503349 C/T cg27129171 chr3:47204927 SETD2 -0.6 -9.36 -0.46 1.29e-18 Colorectal cancer; CRC trans rs2303319 0.504 rs72877343 chr2:162607487 A/C cg09481857 chr22:21368659 P2RX6;MGC16703 -0.65 -6.31 -0.33 9.13e-10 Cognitive function; CRC trans rs9929218 1.000 rs7186084 chr16:68816260 C/G cg04657470 chr2:198365150 HSPE1;HSPD1 0.82 11.82 0.55 4.14e-27 Colorectal cancer; CRC cis rs75804782 0.641 rs41264155 chr2:239342096 G/A cg18131467 chr2:239335373 ASB1 -0.71 -6.28 -0.33 1.06e-9 Morning vs. evening chronotype;Chronotype; CRC cis rs17345786 1.000 rs7641261 chr3:101279006 C/T cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.59 6.92 0.36 2.35e-11 Colonoscopy-negative controls vs population controls; CRC cis rs8180040 0.966 rs56351005 chr3:47430186 G/T cg10298567 chr3:47292165 KIF9 0.38 6.11 0.32 2.74e-9 Colorectal cancer; CRC cis rs6762 0.748 rs3059 chr11:840319 C/T cg16425592 chr11:842748 TSPAN4;POLR2L -0.56 -8.23 -0.41 4.39e-15 Mean platelet volume; CRC trans rs2727020 0.573 rs7925419 chr11:49231859 C/T cg21153622 chr11:89784906 NA -0.48 -8.09 -0.41 1.17e-14 Coronary artery disease; CRC cis rs60871478 0.679 rs62432240 chr7:794813 A/G cg13798912 chr7:905769 UNC84A 0.57 6.13 0.32 2.48e-9 Cerebrospinal P-tau181p levels; CRC trans rs9291683 0.530 rs10939620 chr4:9946132 C/T cg26043149 chr18:55253948 FECH -0.52 -7.84 -0.4 6.49e-14 Bone mineral density; CRC trans rs6600671 1.000 rs11249350 chr1:121178446 C/T cg09829573 chr1:144692074 NBPF9 -0.4 -5.97 -0.31 6.28e-9 Hip geometry; CRC cis rs6502050 0.842 rs8080305 chr17:80074516 A/C cg19223190 chr17:80058835 NA -0.42 -6.72 -0.35 7.89e-11 Life satisfaction; CRC cis rs10089 0.953 rs3805615 chr5:127519049 A/G cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.69 9.34 0.46 1.45e-18 Ileal carcinoids; CRC cis rs4319547 0.656 rs10773088 chr12:122828069 A/T cg05707623 chr12:122985044 ZCCHC8 -0.7 -8.62 -0.43 2.95e-16 Body mass index; CRC cis rs9311676 0.656 rs62258120 chr3:58391128 G/A cg06643156 chr3:58380774 PXK 0.41 6.33 0.33 7.82e-10 Systemic lupus erythematosus; CRC cis rs4819052 0.851 rs914218 chr21:46698445 G/C cg02159808 chr21:46707872 POFUT2;LOC642852 0.52 6.77 0.35 5.77e-11 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs6723226 0.764 rs176403 chr2:32637864 C/A cg02381751 chr2:32503542 YIPF4 -0.64 -9.45 -0.46 6.38e-19 Intelligence (multi-trait analysis); CRC cis rs3741151 0.686 rs7129990 chr11:73124441 A/G cg17517138 chr11:73019481 ARHGEF17 0.55 6.13 0.32 2.53e-9 GIP levels in response to oral glucose tolerance test (120 minutes); CRC cis rs12594515 1.000 rs58368732 chr15:45990531 G/C cg19682013 chr15:45996608 NA 0.32 6.7 0.35 9.09e-11 Waist circumference;Weight; CRC cis rs2576037 0.526 rs998819 chr18:44564181 C/T cg19077165 chr18:44547161 KATNAL2 0.6 9.65 0.47 1.49e-19 Personality dimensions; CRC cis rs6066835 0.867 rs6090901 chr20:47370788 T/C cg18078177 chr20:47281410 PREX1 0.69 5.92 0.31 8.29e-9 Multiple myeloma; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg08108993 chr17:38136923 PSMD3 0.5 6.24 0.33 1.33e-9 Thyroid stimulating hormone; CRC cis rs13394619 0.875 rs9287734 chr2:11724475 A/G cg07314298 chr2:11723111 GREB1 -0.48 -8.12 -0.41 9.74e-15 Endometriosis; CRC cis rs921968 0.509 rs10932782 chr2:219353195 C/T cg02176678 chr2:219576539 TTLL4 0.54 8.69 0.43 1.78e-16 Mean corpuscular hemoglobin concentration; CRC cis rs10911232 0.507 rs10732271 chr1:183025898 C/T ch.1.3577855R chr1:183094577 LAMC1 0.83 14.62 0.63 1.24e-37 Hypertriglyceridemia; CRC cis rs2153535 0.580 rs9406164 chr6:8470048 C/T cg21535247 chr6:8435926 SLC35B3 0.5 7.53 0.38 4.89e-13 Motion sickness; CRC cis rs1003719 0.641 rs13046844 chr21:38517603 A/G cg10648535 chr21:38446584 PIGP;TTC3 -0.48 -6.68 -0.35 1.03e-10 Eye color traits; CRC trans rs11098499 0.863 rs3822191 chr4:120428101 A/T cg25214090 chr10:38739885 LOC399744 0.63 9.76 0.47 6.33e-20 Corneal astigmatism; CRC cis rs10504229 0.775 rs56082079 chr8:58163732 T/C cg20607798 chr8:58055168 NA 0.47 5.79 0.3 1.67e-8 Developmental language disorder (linguistic errors); CRC cis rs4808199 0.901 rs11669516 chr19:19532682 G/A cg03709012 chr19:19516395 GATAD2A 1.04 12.76 0.58 1.48e-30 Nonalcoholic fatty liver disease; CRC cis rs1401999 0.966 rs2313216 chr3:183637251 C/T cg01324343 chr3:183735012 ABCC5 0.76 13.64 0.6 7.08e-34 Anterior chamber depth; CRC cis rs9467711 0.606 rs12176317 chr6:26372786 A/G cg14345882 chr6:26364793 BTN3A2 0.65 5.73 0.3 2.32e-8 Autism spectrum disorder or schizophrenia; CRC cis rs2228479 0.681 rs10153055 chr16:89965842 C/T cg06558623 chr16:89946397 TCF25 0.56 6.36 0.33 6.62e-10 Skin colour saturation; CRC trans rs1005277 0.579 rs116912400 chr10:38479207 G/T cg17830980 chr10:43048298 ZNF37B -0.6 -9.93 -0.48 1.76e-20 Extrinsic epigenetic age acceleration; CRC cis rs1348850 0.914 rs7587604 chr2:178309848 T/A cg02961200 chr2:178257176 LOC100130691;AGPS 0.58 8.55 0.43 4.8e-16 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs1552244 1.000 rs9875081 chr3:10083935 G/A cg13047869 chr3:10149882 C3orf24 0.53 7.44 0.38 8.73e-13 Alzheimer's disease; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg25626508 chr5:54469057 CDC20B;MIR449C 0.37 6.05 0.32 4.01e-9 Intelligence (multi-trait analysis); CRC cis rs7487075 0.619 rs4768718 chr12:46834336 G/C cg22049899 chr12:47219821 SLC38A4 0.31 5.75 0.3 2.08e-8 Itch intensity from mosquito bite; CRC cis rs4654899 0.733 rs10799677 chr1:21318456 A/C cg02927042 chr1:21476669 EIF4G3 -0.41 -6.66 -0.34 1.14e-10 Superior frontal gyrus grey matter volume; CRC cis rs932541 1.000 rs6043991 chr20:16457369 C/T cg17003395 chr20:16555519 KIF16B 0.41 5.62 0.3 4e-8 Intelligence; CRC trans rs9291683 0.588 rs2240722 chr4:10020757 A/G cg26043149 chr18:55253948 FECH 0.51 7.96 0.4 2.86e-14 Bone mineral density; CRC cis rs4319547 0.915 rs7314638 chr12:122983460 A/G cg23029597 chr12:123009494 RSRC2 -0.61 -7.61 -0.39 2.96e-13 Body mass index; CRC cis rs1707322 0.752 rs12024590 chr1:46127496 A/C cg03146154 chr1:46216737 IPP 0.66 9.65 0.47 1.44e-19 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC trans rs916888 0.773 rs199443 chr17:44819565 C/T cg22968622 chr17:43663579 NA 1.4 18.96 0.72 1.04e-54 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs7632954 0.904 rs968160 chr3:8523334 G/A cg03495237 chr3:8533978 NA 0.33 5.63 0.3 3.81e-8 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs4838594 0.563 rs9794032 chr10:49681286 A/G cg17291251 chr10:49678358 ARHGAP22 0.46 7.26 0.37 2.82e-12 Daytime sleep phenotypes; CRC cis rs524023 0.957 rs528211 chr11:64351721 C/T cg06522879 chr11:64358276 SLC22A12 0.55 8.66 0.43 2.12e-16 Urate levels in obese individuals; CRC cis rs7945718 0.806 rs7927346 chr11:12835835 C/T cg25843174 chr11:12811716 TEAD1 0.47 8.77 0.44 9.67e-17 Educational attainment (years of education); CRC cis rs2013441 1.000 rs972966 chr17:20030992 G/C cg13482628 chr17:19912719 NA 0.39 6.09 0.32 3.08e-9 Obesity-related traits; CRC cis rs6540556 0.834 rs11119337 chr1:209934133 A/G cg23920097 chr1:209922102 NA -0.49 -6.33 -0.33 7.98e-10 Red blood cell count; CRC cis rs753778 0.962 rs4961341 chr8:142235154 G/T cg23750338 chr8:142222470 SLC45A4 0.39 5.87 0.31 1.06e-8 Reticulocyte fraction of red cells;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; CRC cis rs1552244 1.000 rs17032276 chr3:10076975 A/C cg16606324 chr3:10149918 C3orf24 0.73 9.77 0.47 5.73e-20 Alzheimer's disease; CRC cis rs6502050 0.698 rs6502076 chr17:80121978 A/G cg11859384 chr17:80120422 CCDC57 -0.36 -5.75 -0.3 2.06e-8 Life satisfaction; CRC cis rs875971 0.508 rs10242423 chr7:66059175 A/G cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.42 -6.27 -0.33 1.14e-9 Aortic root size; CRC trans rs10139154 0.782 rs229221 chr14:31004226 T/C cg18753625 chr19:36705707 ZNF565;ZNF146 -0.42 -5.99 -0.31 5.38e-9 Amyotrophic lateral sclerosis; CRC cis rs7945705 0.935 rs2568062 chr11:8887945 A/G cg21881798 chr11:8931708 C11orf17;ST5 -0.75 -12.87 -0.58 5.46e-31 Hemoglobin concentration; CRC cis rs13118159 0.550 rs10016557 chr4:1363628 C/T cg16405210 chr4:1374714 KIAA1530 0.85 12.84 0.58 7.12e-31 Longevity; CRC trans rs4378999 0.660 rs9820606 chr3:50771819 G/A cg12383621 chr7:7735611 RPA3 -0.48 -6.05 -0.32 3.92e-9 Waist circumference adjusted for BMI in non-smokers;Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction); CRC cis rs7552404 0.889 rs1250874 chr1:76190978 A/G cg10523679 chr1:76189770 ACADM 0.78 11.99 0.55 9.62e-28 Blood metabolite levels;Acylcarnitine levels; CRC cis rs6938 0.534 rs1133322 chr15:75212357 A/G cg17294928 chr15:75287854 SCAMP5 0.6 9.42 0.46 8.38e-19 Breast cancer; CRC cis rs7923609 0.841 rs10761786 chr10:65336207 T/C cg08743896 chr10:65200160 JMJD1C -0.4 -5.7 -0.3 2.69e-8 Educational attainment;Liver enzyme levels (alkaline phosphatase); CRC cis rs2427308 0.643 rs477859 chr20:60937597 A/G cg24112000 chr20:60950667 NA 0.54 8.55 0.43 4.78e-16 Colorectal cancer; CRC cis rs3820068 0.581 rs2861387 chr1:15951296 G/A cg13390004 chr1:15929781 NA 0.49 7.0 0.36 1.45e-11 Systolic blood pressure; CRC cis rs4523957 0.928 rs216223 chr17:2155948 C/T cg16513277 chr17:2031491 SMG6 0.5 8.29 0.42 2.92e-15 Autism spectrum disorder or schizophrenia;Schizophrenia; CRC cis rs9910055 0.762 rs4239142 chr17:42205876 A/G cg10896456 chr17:42255109 ASB16;C17orf65 -0.45 -7.38 -0.38 1.32e-12 Total body bone mineral density; CRC cis rs13118159 0.836 rs2276903 chr4:1343405 A/G cg24560729 chr4:1342394 KIAA1530 0.44 7.99 0.4 2.3e-14 Longevity; CRC cis rs4631830 0.900 rs7914347 chr10:51537431 C/T cg16070123 chr10:51489643 NA -0.34 -5.85 -0.31 1.2e-8 Prostate-specific antigen levels; CRC trans rs2727020 0.553 rs4103567 chr11:49255389 C/T cg21153622 chr11:89784906 NA -0.49 -8.13 -0.41 8.82e-15 Coronary artery disease; CRC cis rs4731207 0.564 rs10260039 chr7:124603546 A/G cg23710748 chr7:124431027 NA -0.39 -6.22 -0.32 1.47e-9 Cutaneous malignant melanoma; CRC cis rs2249694 0.520 rs7911139 chr10:135323525 T/C cg20169779 chr10:135381914 SYCE1 -0.53 -7.24 -0.37 3.18e-12 Obesity-related traits; CRC cis rs7781557 1.000 rs7790451 chr7:102465988 G/A cg18108683 chr7:102477205 FBXL13 -0.5 -6.62 -0.34 1.46e-10 Colorectal adenoma (advanced); CRC cis rs4481887 1.000 rs4244180 chr1:248471033 A/G cg00666640 chr1:248458726 OR2T12 0.54 9.63 0.47 1.74e-19 Common traits (Other); CRC cis rs35995292 0.534 rs13228087 chr7:38909204 A/C cg19327137 chr7:38886074 VPS41 0.67 11.44 0.53 1e-25 Subjective well-being (multi-trait analysis); CRC trans rs1814175 0.781 rs1851872 chr11:50009770 A/G cg15704280 chr7:45808275 SEPT13 -0.99 -20.61 -0.75 3.6e-61 Height; CRC cis rs2882667 0.652 rs6596463 chr5:138444926 A/G cg09476006 chr5:138032270 NA 0.43 6.99 0.36 1.5e-11 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs4808199 0.901 rs12973258 chr19:19488718 T/C cg03709012 chr19:19516395 GATAD2A 1.02 12.29 0.56 8.09e-29 Nonalcoholic fatty liver disease; CRC cis rs8031584 0.697 rs798080 chr15:31122169 T/C cg08109568 chr15:31115862 NA 0.65 10.37 0.5 5.65e-22 Huntington's disease progression; CRC cis rs12024301 0.557 rs79746696 chr1:183608776 A/G cg11505048 chr1:183622726 RGL1;APOBEC4 0.81 6.83 0.35 4.19e-11 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs4713118 0.512 rs2622319 chr6:28120401 G/C cg15845792 chr6:28175446 NA 0.82 12.17 0.56 2.24e-28 Parkinson's disease; CRC cis rs7772486 0.623 rs9485021 chr6:146068797 A/G cg13319975 chr6:146136371 FBXO30 0.44 6.54 0.34 2.4e-10 Lobe attachment (rater-scored or self-reported); CRC cis rs11577318 0.853 rs4471263 chr1:26622700 C/T cg04990556 chr1:26633338 UBXN11 -0.48 -6.09 -0.32 3.22e-9 Granulocyte percentage of myeloid white cells; CRC cis rs3858526 0.959 rs61876223 chr11:5943393 G/A cg13902645 chr11:5959945 NA -0.64 -8.97 -0.44 2.27e-17 DNA methylation (variation); CRC cis rs2243480 1.000 rs73150014 chr7:65450919 A/C cg25985355 chr7:65971099 NA -0.48 -5.69 -0.3 2.87e-8 Diabetic kidney disease; CRC cis rs2346177 0.816 rs74179078 chr2:46654651 T/A cg26688816 chr2:46740690 ATP6V1E2 -0.52 -8.22 -0.41 4.68e-15 HDL cholesterol; CRC cis rs3825932 0.744 rs11072818 chr15:79236933 A/G cg25744700 chr15:79237217 CTSH 0.4 5.99 0.31 5.35e-9 Type 1 diabetes; CRC cis rs826838 0.967 rs826879 chr12:39088999 A/C cg13010199 chr12:38710504 ALG10B -0.4 -5.9 -0.31 9e-9 Heart rate; CRC trans rs2303319 0.504 rs62189047 chr2:162613314 T/A cg11326919 chr17:43324904 LOC100133991 -0.64 -5.97 -0.31 5.99e-9 Cognitive function; CRC cis rs12497850 0.931 rs6446205 chr3:49035211 C/T cg07636037 chr3:49044803 WDR6 1.05 19.22 0.73 9.69e-56 Parkinson's disease; CRC cis rs802075 0.765 rs2145331 chr6:49598877 G/C cg20364632 chr6:49636226 NA -0.34 -5.64 -0.3 3.64e-8 Bone mineral density (hip) and age at menarche; CRC trans rs10504229 1.000 rs117231141 chr8:58185465 A/G cg04077850 chr5:125800366 GRAMD3 0.37 6.27 0.33 1.15e-9 Developmental language disorder (linguistic errors); CRC cis rs7503807 1.000 rs4889775 chr17:78592287 A/G cg09596252 chr17:78655493 RPTOR 0.38 5.99 0.31 5.6e-9 Obesity; CRC cis rs7412746 0.658 rs4970987 chr1:150949682 T/C cg17724175 chr1:150552817 MCL1 0.47 6.91 0.36 2.47e-11 Melanoma; CRC cis rs1178968 0.901 rs2528705 chr7:72791238 A/G cg25889504 chr7:72793014 NA 0.55 6.02 0.32 4.61e-9 Triglyceride levels; CRC cis rs6502050 0.835 rs8079389 chr17:80158656 T/G cg13198984 chr17:80129470 CCDC57 0.43 7.5 0.38 6.19e-13 Life satisfaction; CRC cis rs11997175 0.624 rs4733460 chr8:33675169 T/C ch.8.33884649F chr8:33765107 NA 0.43 6.09 0.32 3.11e-9 Body mass index; CRC cis rs950169 0.881 rs62029596 chr15:84955434 A/G cg11189052 chr15:85197271 WDR73 0.63 8.8 0.44 7.65e-17 Schizophrenia; CRC cis rs59104589 0.583 rs3771573 chr2:242387346 G/A cg19488206 chr2:242435732 STK25 0.49 7.12 0.37 6.8e-12 Fibrinogen levels; CRC cis rs6969780 0.915 rs17471520 chr7:27178790 T/C cg26364809 chr7:27145159 NA -0.75 -6.96 -0.36 1.87e-11 Diastolic blood pressure;Blood pressure traits (multi-trait analysis);Systolic blood pressure;Hypertension; CRC cis rs9814567 1.000 rs13096604 chr3:134250099 G/T cg06109529 chr3:134205091 CEP63;ANAPC13 0.83 12.22 0.56 1.46e-28 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs11719291 0.915 rs11557629 chr3:48732223 G/A cg00383909 chr3:49044727 WDR6 0.75 7.89 0.4 4.65e-14 Cognitive function; CRC cis rs6952808 0.609 rs6944877 chr7:1952582 T/G cg04267008 chr7:1944627 MAD1L1 -0.61 -9.37 -0.46 1.21e-18 Bipolar disorder and schizophrenia; CRC cis rs9322193 0.962 rs4816 chr6:150114745 G/A cg00933542 chr6:150070202 PCMT1 0.28 5.63 0.3 3.86e-8 Lung cancer; CRC cis rs13144136 0.687 rs11725559 chr4:10654270 A/G cg10242279 chr4:10666415 CLNK 0.37 6.22 0.32 1.5e-9 Resistance to antihypertensive treatment in hypertension; CRC cis rs7131987 0.834 rs12228468 chr12:29453610 A/C cg09582351 chr12:29534625 ERGIC2 0.36 7.77 0.39 1.01e-13 QT interval; CRC cis rs769267 1.000 rs7246748 chr19:19433105 C/T cg03709012 chr19:19516395 GATAD2A -0.67 -10.36 -0.5 5.7e-22 Tonsillectomy; CRC cis rs1448094 0.556 rs61930632 chr12:86168937 A/C cg19622623 chr12:86230825 RASSF9 -0.37 -5.62 -0.3 4.06e-8 Major depressive disorder; CRC cis rs56307353 0.513 rs2041120 chr19:1961474 C/T cg08800497 chr19:1970008 CSNK1G2 0.7 11.39 0.53 1.52e-25 Coronary artery disease; CRC cis rs2842992 0.789 rs10945635 chr6:160214487 C/A cg19482086 chr6:160211437 TCP1;MRPL18 0.74 9.54 0.47 3.36e-19 Age-related macular degeneration (geographic atrophy); CRC cis rs1046896 0.553 rs9893885 chr17:80837107 C/T cg19500275 chr17:80737654 TBCD 0.53 7.15 0.37 5.5e-12 Glycated hemoglobin levels; CRC cis rs7666738 0.830 rs11725095 chr4:99009711 T/A cg05340658 chr4:99064831 C4orf37 0.61 9.54 0.47 3.44e-19 Colonoscopy-negative controls vs population controls; CRC cis rs1129187 0.755 rs9462855 chr6:42925936 G/C cg00597713 chr6:42947103 PEX6 -0.4 -5.62 -0.3 4.12e-8 Alzheimer's disease in APOE e4+ carriers; CRC cis rs801193 0.569 rs881285 chr7:66119420 A/G cg12463550 chr7:65579703 CRCP -0.46 -6.16 -0.32 2.1e-9 Aortic root size; CRC cis rs8141529 0.748 rs132528 chr22:29295898 C/T cg02153584 chr22:29168773 CCDC117 -0.47 -6.81 -0.35 4.53e-11 Lymphocyte counts; CRC cis rs3106136 0.967 rs2306803 chr4:95161996 C/T cg11021082 chr4:95130006 SMARCAD1 -0.45 -6.47 -0.34 3.59e-10 Capecitabine sensitivity; CRC cis rs6963495 0.818 rs73192149 chr7:105210910 A/G cg02135003 chr7:105160482 PUS7 -0.96 -12.76 -0.58 1.42e-30 Bipolar disorder (body mass index interaction); CRC cis rs950169 0.580 rs11634320 chr15:85172183 A/C cg11189052 chr15:85197271 WDR73 -0.63 -9.33 -0.46 1.57e-18 Schizophrenia; CRC cis rs4332037 0.510 rs11764040 chr7:1884830 G/C cg23378565 chr7:2036160 MAD1L1 -0.38 -6.49 -0.34 3.07e-10 Bipolar disorder; CRC cis rs853679 0.550 rs34477097 chr6:28197186 C/T cg03623178 chr6:28175578 NA 0.85 11.62 0.54 2.25e-26 Depression; CRC cis rs644799 1.000 rs472231 chr11:95532166 A/G cg25622487 chr11:95524042 FAM76B;CEP57 0.76 11.87 0.55 2.62e-27 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs1109861 1.000 rs1109861 chr10:11246269 A/C cg24910943 chr10:11206320 CUGBP2 0.21 5.74 0.3 2.11e-8 Urinary albumin-to-creatinine ratio; CRC cis rs2249625 0.504 rs2496508 chr6:72891398 A/G cg18830697 chr6:72922368 RIMS1 -0.4 -8.05 -0.41 1.58e-14 Acute urticaria and angioedema (non-steroidal anti-inflammatory drug-induced); CRC cis rs10504229 0.906 rs903718 chr8:58167726 A/G cg22535103 chr8:58192502 C8orf71 -0.67 -10.75 -0.51 2.75e-23 Developmental language disorder (linguistic errors); CRC cis rs853679 0.517 rs9357063 chr6:28060005 G/A cg06470822 chr6:28175283 NA 1.0 13.22 0.59 2.7e-32 Depression; CRC cis rs11627756 0.958 rs4906238 chr14:103077702 G/A cg12046867 chr14:103022105 NA -0.42 -5.72 -0.3 2.36e-8 Mean platelet volume; CRC cis rs72945132 0.882 rs7941933 chr11:70123351 G/A cg14191688 chr11:70257035 CTTN 0.49 6.59 0.34 1.79e-10 Coronary artery disease; CRC cis rs1448094 0.838 rs28509446 chr12:86312584 A/C cg19622623 chr12:86230825 RASSF9 -0.4 -6.43 -0.33 4.53e-10 Major depressive disorder; CRC cis rs1707322 0.717 rs1135850 chr1:46093692 G/A cg06784218 chr1:46089804 CCDC17 0.66 12.02 0.55 7.8e-28 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs9393692 0.627 rs2179517 chr6:26198845 G/C cg13736514 chr6:26305472 NA -0.52 -9.33 -0.46 1.59e-18 Educational attainment; CRC cis rs921968 0.643 rs611203 chr2:219472325 G/A cg02176678 chr2:219576539 TTLL4 0.49 8.29 0.42 2.99e-15 Mean corpuscular hemoglobin concentration; CRC cis rs9912789 0.744 rs9893755 chr17:79187432 C/T cg14413466 chr17:79170920 AZI1 0.38 6.52 0.34 2.65e-10 Frontotemporal dementia; CRC cis rs611744 0.538 rs13257548 chr8:109273185 G/A cg21045802 chr8:109455806 TTC35 0.46 7.02 0.36 1.24e-11 Dupuytren's disease; CRC cis rs798766 1.000 rs1665364 chr4:1727206 A/G cg02089348 chr4:1724449 TMEM129;TACC3 0.38 5.64 0.3 3.73e-8 Bladder cancer;Urinary bladder cancer; CRC cis rs17401966 0.931 rs10492972 chr1:10353112 A/G cg19773385 chr1:10388646 KIF1B -0.68 -11.11 -0.52 1.42e-24 Hepatocellular carcinoma; CRC cis rs1267303 1.000 rs1267303 chr1:46990457 A/G cg08533674 chr1:46993347 NA -0.51 -6.89 -0.35 2.92e-11 Monobrow; CRC cis rs12541335 0.639 rs11779277 chr8:22200683 C/T cg18135555 chr8:22132992 PIWIL2 0.41 7.88 0.4 4.72e-14 Hypertriglyceridemia; CRC cis rs1577917 0.655 rs9342045 chr6:86425148 C/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A 0.55 7.86 0.4 5.5e-14 Response to antipsychotic treatment; CRC cis rs8060686 0.920 rs112894876 chr16:67812039 G/C cg10544611 chr16:67998164 SLC12A4 -0.53 -5.64 -0.3 3.66e-8 HDL cholesterol;Metabolic syndrome; CRC cis rs11622475 1.000 rs2236246 chr14:104379206 A/C cg12183467 chr14:104352244 NA 0.54 7.41 0.38 1.11e-12 Bipolar disorder; CRC cis rs7843479 0.965 rs11135741 chr8:21801091 C/T cg17168535 chr8:21777572 XPO7 0.58 9.55 0.47 3.1e-19 Mean corpuscular volume; CRC cis rs798766 1.000 rs798762 chr4:1731150 T/C cg02089348 chr4:1724449 TMEM129;TACC3 -0.4 -5.82 -0.31 1.43e-8 Bladder cancer;Urinary bladder cancer; CRC cis rs6860806 0.603 rs112300250 chr5:131583292 G/A cg12564285 chr5:131593104 PDLIM4 0.48 9.3 0.46 2.09e-18 Breast cancer; CRC cis rs67311347 0.605 rs1880762 chr3:40283215 A/G cg09455208 chr3:40491958 NA 0.33 6.93 0.36 2.18e-11 Renal cell carcinoma; CRC cis rs1153858 1.000 rs1365610 chr15:45694610 C/T cg21132104 chr15:45694354 SPATA5L1 0.63 8.88 0.44 4.3e-17 Homoarginine levels; CRC trans rs2018683 0.624 rs1006521 chr7:28996220 G/A cg19402173 chr7:128379420 CALU -0.52 -7.57 -0.39 3.67e-13 Response to irinotecan and platinum-based chemotherapy in non-small-cell lung cancer; CRC cis rs10982256 0.870 rs10817625 chr9:117247587 A/T cg13636371 chr9:117264095 DFNB31 0.31 5.9 0.31 8.85e-9 Bipolar disorder; CRC cis rs898097 0.812 rs56274787 chr17:80862682 C/T cg15664640 chr17:80829946 TBCD -0.71 -11.96 -0.55 1.25e-27 Breast cancer; CRC cis rs67340775 0.541 rs200968 chr6:27859568 T/C cg08798685 chr6:27730294 NA -0.57 -6.32 -0.33 8.54e-10 Lung cancer in ever smokers; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg02422812 chr5:154062204 NA 0.43 6.1 0.32 2.98e-9 Response to antipsychotic treatment; CRC cis rs1570884 0.516 rs9535268 chr13:50175478 C/A cg02321871 chr13:50159138 RCBTB1 -0.44 -6.17 -0.32 2e-9 Sum basophil neutrophil counts;Sum neutrophil eosinophil counts;Neutrophil count;Myeloid white cell count;Granulocyte count; CRC cis rs7085104 0.660 rs7902804 chr10:104585405 A/T cg15744005 chr10:104629667 AS3MT -0.38 -7.95 -0.4 3.05e-14 Immature fraction of reticulocytes;Schizophrenia; CRC cis rs780096 0.526 rs704791 chr2:27657167 T/C cg22903471 chr2:27725779 GCKR -0.37 -6.05 -0.32 4.04e-9 Total body bone mineral density; CRC cis rs2046867 0.818 rs60228315 chr3:72805034 C/A cg25664220 chr3:72788482 NA -0.47 -6.59 -0.34 1.76e-10 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; CRC cis rs7591163 1.000 rs1721359 chr2:228751874 C/T cg00063174 chr2:228736253 WDR69 -0.5 -6.73 -0.35 7.7e-11 Blood pressure; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg25408707 chr6:160393049 IGF2R 0.41 6.29 0.33 1.04e-9 Liver disease severity in Alagille syndrome; CRC cis rs17641971 0.684 rs11990854 chr8:49992048 T/C cg00325661 chr8:49890786 NA 0.37 6.22 0.32 1.51e-9 Blood metabolite levels; CRC cis rs12348691 0.503 rs7849497 chr9:100615660 G/C cg13688889 chr9:100608707 NA -0.47 -6.05 -0.32 3.87e-9 Alopecia areata; CRC cis rs12760731 0.517 rs34437852 chr1:178228721 T/C cg00404053 chr1:178313656 RASAL2 1.13 11.64 0.54 1.86e-26 Obesity-related traits; CRC cis rs7772486 0.701 rs697056 chr6:146003897 C/T cg23711669 chr6:146136114 FBXO30 -0.74 -12.45 -0.57 2.09e-29 Lobe attachment (rater-scored or self-reported); CRC trans rs2243480 1.000 rs422164 chr7:65586605 C/G cg10756647 chr7:56101905 PSPH 0.73 7.79 0.39 8.92e-14 Diabetic kidney disease; CRC cis rs713477 0.631 rs7145182 chr14:55905231 C/G cg21836586 chr14:55907198 TBPL2 0.31 5.6 0.3 4.52e-8 Pediatric bone mineral content (femoral neck); CRC cis rs10504229 0.953 rs57131327 chr8:58171895 T/C cg05313129 chr8:58192883 C8orf71 -0.47 -6.99 -0.36 1.49e-11 Developmental language disorder (linguistic errors); CRC cis rs3736485 0.966 rs11634180 chr15:51895757 G/C cg08986416 chr15:51914746 DMXL2 -0.47 -6.7 -0.35 9e-11 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs12474201 0.928 rs12999586 chr2:46938736 C/T cg06386533 chr2:46925753 SOCS5 0.81 13.21 0.59 3.04e-32 Height; CRC cis rs7618501 0.699 rs2777888 chr3:49898000 A/G cg05623727 chr3:50126028 RBM5 0.45 7.23 0.37 3.47e-12 Intelligence (multi-trait analysis); CRC cis rs7918232 0.882 rs6415983 chr10:27357211 A/G cg14240646 chr10:27532245 ACBD5 -0.81 -9.05 -0.45 1.23e-17 Breast cancer; CRC trans rs4263408 0.934 rs9683743 chr4:39703194 A/C cg23172898 chr14:34931803 C14orf147 -0.41 -6.13 -0.32 2.55e-9 Plasma amyloid beta peptide concentrations (ABx-40); CRC cis rs4604732 0.631 rs1106720 chr1:247624681 T/C cg02104434 chr1:247694406 LOC148824;OR2C3 0.6 8.92 0.44 3.24e-17 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CRC cis rs7119 0.667 rs1058129 chr15:77905661 A/G cg10437265 chr15:77819839 NA -0.48 -8.37 -0.42 1.64e-15 Type 2 diabetes; CRC cis rs10504229 0.593 rs77607045 chr8:58010464 T/C cg21724239 chr8:58056113 NA 0.77 9.81 0.48 4.41e-20 Developmental language disorder (linguistic errors); CRC cis rs3760982 0.585 rs11083724 chr19:44298988 A/G cg11993925 chr19:44307056 LYPD5 0.57 10.3 0.49 9.35e-22 Breast cancer (estrogen-receptor negative);Breast cancer; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg01482980 chr7:92861284 CCDC132 0.46 5.96 0.31 6.43e-9 Thyroid stimulating hormone; CRC cis rs10924970 0.967 rs12731177 chr1:235463173 T/G cg26050004 chr1:235667680 B3GALNT2 0.4 5.89 0.31 9.61e-9 Asthma; CRC cis rs12893668 0.514 rs3212090 chr14:104168863 C/T cg01849466 chr14:104193079 ZFYVE21 -0.42 -6.2 -0.32 1.7e-9 Reticulocyte count; CRC cis rs72781680 0.665 rs72788298 chr2:24104293 T/C cg08917208 chr2:24149416 ATAD2B 0.53 6.37 0.33 6.54e-10 Lymphocyte counts; CRC cis rs10256972 0.552 rs2960831 chr7:1201192 A/T cg23978390 chr7:1156363 C7orf50 0.47 6.49 0.34 3.13e-10 Longevity;Endometriosis; CRC cis rs1570884 0.516 rs9535268 chr13:50175478 C/A cg03651054 chr13:50194643 NA 0.36 7.29 0.37 2.39e-12 Sum basophil neutrophil counts;Sum neutrophil eosinophil counts;Neutrophil count;Myeloid white cell count;Granulocyte count; CRC cis rs9903692 0.697 rs6504024 chr17:46165586 T/C cg21215337 chr17:46176117 CBX1 0.42 7.78 0.39 9.74e-14 Pulse pressure; CRC cis rs7914558 0.966 rs7921574 chr10:104840970 T/C cg15744005 chr10:104629667 AS3MT -0.34 -7.22 -0.37 3.72e-12 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs2991971 0.933 rs12568144 chr1:45965307 G/A cg24296786 chr1:45957014 TESK2 0.55 8.28 0.42 3.08e-15 High light scatter reticulocyte count; CRC cis rs9611565 0.659 rs4822036 chr22:41936019 A/G cg06634786 chr22:41940651 POLR3H -0.65 -7.62 -0.39 2.66e-13 Vitiligo; CRC cis rs6988636 1.000 rs16898086 chr8:124190445 A/G cg27053337 chr8:124217698 FAM83A 0.43 6.59 0.34 1.74e-10 Urinary uromodulin levels; CRC trans rs4824093 0.610 rs4824113 chr22:50284974 C/T cg09872104 chr7:134855509 C7orf49 -0.82 -7.2 -0.37 4e-12 Amyotrophic lateral sclerosis (sporadic); CRC cis rs7412746 0.658 rs10305704 chr1:150804429 A/C cg18016565 chr1:150552671 MCL1 0.45 6.27 0.33 1.13e-9 Melanoma; CRC cis rs9325144 0.600 rs2171405 chr12:38741030 G/T cg26384229 chr12:38710491 ALG10B -0.55 -8.0 -0.4 2.22e-14 Morning vs. evening chronotype; CRC cis rs7209700 0.662 rs8066295 chr17:45348203 A/G cg17185639 chr17:45330862 ITGB3 -0.36 -5.85 -0.31 1.2e-8 IgG glycosylation; CRC trans rs9868809 0.881 rs9878063 chr3:48678971 T/G cg03060546 chr3:49711283 APEH -0.55 -6.05 -0.32 3.94e-9 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; CRC cis rs12479064 0.724 rs3087403 chr2:100058870 C/T cg26064155 chr2:99771622 LIPT1;TSGA10 -0.56 -7.25 -0.37 2.98e-12 Chronic sinus infection; CRC cis rs858239 1.000 rs156407 chr7:23315639 G/A cg00469287 chr7:23338798 C7orf30 0.47 6.31 0.33 8.77e-10 Cerebrospinal fluid biomarker levels; CRC cis rs10256972 0.552 rs2960837 chr7:1203957 A/G cg18765753 chr7:1198926 ZFAND2A -0.41 -7.26 -0.37 2.81e-12 Longevity;Endometriosis; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg05531134 chr21:19192027 C21orf91 0.37 6.07 0.32 3.51e-9 Liver disease severity in Alagille syndrome; CRC cis rs2033908 0.502 rs12361858 chr11:12857064 C/T cg25843174 chr11:12811716 TEAD1 -0.38 -6.7 -0.35 9.01e-11 Sitting height ratio; CRC cis rs3760982 0.967 rs12463346 chr19:44292244 A/G cg11993925 chr19:44307056 LYPD5 0.49 8.02 0.4 1.94e-14 Breast cancer (estrogen-receptor negative);Breast cancer; CRC cis rs35883536 0.588 rs955338 chr1:101108794 G/C cg14515779 chr1:101123966 NA -0.34 -5.97 -0.31 6.17e-9 Monocyte count; CRC cis rs763121 0.925 rs5757251 chr22:39100128 G/A cg06544989 chr22:39130855 UNC84B 0.46 7.42 0.38 1.03e-12 Menopause (age at onset); CRC cis rs10782582 0.593 rs1412717 chr1:76125471 C/T cg03433033 chr1:76189801 ACADM -0.42 -6.1 -0.32 2.94e-9 Daytime sleep phenotypes; CRC cis rs561341 0.709 rs11542477 chr17:30185892 A/G cg23018236 chr17:30244563 NA 0.5 5.93 0.31 7.48e-9 Hip circumference adjusted for BMI; CRC cis rs10504229 0.815 rs72650877 chr8:58164510 T/C cg22535103 chr8:58192502 C8orf71 -0.73 -8.63 -0.43 2.64e-16 Developmental language disorder (linguistic errors); CRC cis rs734999 0.588 rs4648652 chr1:2535758 A/G cg20673091 chr1:2541236 MMEL1 0.36 5.86 0.31 1.13e-8 Ulcerative colitis; CRC cis rs10751667 0.643 rs10902237 chr11:944801 C/A cg01483505 chr11:975446 AP2A2 0.41 6.59 0.34 1.74e-10 Alzheimer's disease (late onset); CRC cis rs1577917 0.771 rs9450319 chr6:86427325 T/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A 0.59 8.39 0.42 1.43e-15 Response to antipsychotic treatment; CRC cis rs4654899 1.000 rs6683542 chr1:21369610 T/C cg02927042 chr1:21476669 EIF4G3 -0.46 -7.36 -0.38 1.44e-12 Superior frontal gyrus grey matter volume; CRC cis rs9926296 0.605 rs3743859 chr16:89846050 A/G cg03388025 chr16:89894329 SPIRE2 -0.4 -7.97 -0.4 2.61e-14 Vitiligo; CRC cis rs34779708 0.931 rs7079205 chr10:35324619 C/T cg03585969 chr10:35415529 CREM 0.56 7.39 0.38 1.2e-12 Inflammatory bowel disease;Crohn's disease; CRC cis rs7666738 0.716 rs11097615 chr4:99092773 T/C cg05340658 chr4:99064831 C4orf37 0.51 7.51 0.38 5.58e-13 Colonoscopy-negative controls vs population controls; CRC cis rs17209837 1.000 rs45607141 chr7:87087025 A/G cg00919237 chr7:87102261 ABCB4 -0.49 -6.03 -0.32 4.4e-9 Gallbladder cancer; CRC trans rs9467711 0.606 rs72841536 chr6:26378288 T/A cg06606381 chr12:133084897 FBRSL1 -0.77 -6.08 -0.32 3.42e-9 Autism spectrum disorder or schizophrenia; CRC trans rs3733585 0.699 rs6449159 chr4:9960498 G/A cg26043149 chr18:55253948 FECH -0.5 -7.62 -0.39 2.81e-13 Cleft plate (environmental tobacco smoke interaction); CRC cis rs6499255 0.951 rs11641233 chr16:69734563 C/T cg00738113 chr16:70207722 CLEC18C -0.38 -5.73 -0.3 2.23e-8 IgE levels; CRC cis rs561341 0.709 rs8068049 chr17:30183857 T/C cg12193833 chr17:30244370 NA 0.56 6.15 0.32 2.24e-9 Hip circumference adjusted for BMI; CRC trans rs9790314 0.905 rs7611367 chr3:161003182 A/G cg03909902 chr12:108154529 PRDM4 -0.43 -6.06 -0.32 3.62e-9 Morning vs. evening chronotype; CRC cis rs9488822 0.676 rs1338667 chr6:116323910 T/A cg05304507 chr6:116381966 FRK 0.3 8.24 0.41 4.08e-15 Cholesterol, total;LDL cholesterol; CRC cis rs9326248 0.953 rs488962 chr11:117072525 C/T cg11861562 chr11:117069780 TAGLN -0.42 -9.24 -0.45 3.27e-18 Blood protein levels; CRC cis rs9322193 0.923 rs56397000 chr6:150060483 C/T cg07701084 chr6:150067640 NUP43 0.61 9.12 0.45 7.81e-18 Lung cancer; CRC cis rs9649465 0.561 rs2429618 chr7:123421662 G/A cg03229431 chr7:123269106 ASB15 0.57 9.22 0.45 3.7e-18 Migraine; CRC cis rs7512552 0.839 rs1103115 chr1:150332304 G/A cg15654264 chr1:150340011 RPRD2 0.59 8.59 0.43 3.42e-16 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); CRC cis rs3733585 0.699 rs7658170 chr4:9966593 C/T cg00071950 chr4:10020882 SLC2A9 0.54 9.37 0.46 1.21e-18 Cleft plate (environmental tobacco smoke interaction); CRC cis rs6570726 0.837 rs419991 chr6:145864212 C/T cg05347473 chr6:146136440 FBXO30 0.38 6.05 0.32 4e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs2295359 0.892 rs4655686 chr1:67638004 T/A cg17031739 chr1:67600172 NA 0.42 6.57 0.34 1.91e-10 Psoriasis; CRC cis rs7209700 1.000 rs7209700 chr17:45351118 A/G cg08085267 chr17:45401833 C17orf57 0.46 6.4 0.33 5.42e-10 IgG glycosylation; CRC cis rs12541335 0.590 rs11136002 chr8:22217082 C/T cg09517075 chr8:22133004 PIWIL2 0.49 8.52 0.43 5.75e-16 Hypertriglyceridemia; CRC cis rs478304 0.654 rs10896029 chr11:65452952 C/T cg05805236 chr11:65401703 PCNXL3 -0.41 -6.54 -0.34 2.29e-10 Acne (severe); CRC cis rs56114371 0.777 rs200483 chr6:27774824 C/T cg26587870 chr6:27730563 NA -0.66 -6.65 -0.34 1.24e-10 Breast cancer; CRC cis rs2836974 0.931 rs2836968 chr21:40642386 A/G cg11644478 chr21:40555479 PSMG1 0.81 12.32 0.56 6.05e-29 Cognitive function; CRC trans rs1923243 0.749 rs12042085 chr1:73602245 T/G cg07861564 chr12:119616618 HSPB8 -0.32 -5.99 -0.31 5.58e-9 Migraine; CRC cis rs714027 1.000 rs714027 chr22:30577771 A/G cg11564601 chr22:30592435 NA 0.38 5.63 0.3 3.86e-8 Lymphocyte counts; CRC cis rs896854 0.654 rs28716845 chr8:95974485 A/G cg09323728 chr8:95962352 TP53INP1 -0.45 -7.47 -0.38 7.48e-13 Type 2 diabetes; CRC cis rs7959452 0.590 rs11177619 chr12:69758871 G/A cg22834771 chr12:69754056 YEATS4 -0.53 -8.03 -0.4 1.79e-14 Blood protein levels; CRC trans rs6940638 1.000 rs12215241 chr6:27023081 G/A cg06606381 chr12:133084897 FBRSL1 -0.62 -6.49 -0.34 3.15e-10 Intelligence (multi-trait analysis); CRC cis rs1865760 0.533 rs1408270 chr6:25873184 A/G cg16482183 chr6:26056742 HIST1H1C 0.74 9.6 0.47 2.05e-19 Height; CRC cis rs10504229 0.683 rs55660024 chr8:58128943 G/A cg21724239 chr8:58056113 NA 0.49 6.81 0.35 4.75e-11 Developmental language disorder (linguistic errors); CRC cis rs832540 0.552 rs252924 chr5:56205643 A/G cg20203395 chr5:56204925 C5orf35 -0.46 -6.42 -0.33 4.8e-10 Coronary artery disease; CRC cis rs6460942 0.915 rs2216051 chr7:12304054 G/A cg06484146 chr7:12443880 VWDE -0.5 -6.46 -0.34 3.71e-10 Coronary artery disease; CRC cis rs1448094 0.533 rs7955135 chr12:86146350 G/A cg25456477 chr12:86230367 RASSF9 -0.36 -6.07 -0.32 3.43e-9 Major depressive disorder; CRC cis rs7552404 0.627 rs12127049 chr1:76353248 G/A cg10523679 chr1:76189770 ACADM 0.72 8.53 0.43 5.55e-16 Blood metabolite levels;Acylcarnitine levels; CRC cis rs4481887 0.604 rs6694598 chr1:248409490 A/G cg00666640 chr1:248458726 OR2T12 0.41 6.55 0.34 2.26e-10 Common traits (Other); CRC cis rs6502050 0.529 rs35585236 chr17:80116641 T/C cg19223190 chr17:80058835 NA 0.39 6.31 0.33 9.07e-10 Life satisfaction; CRC trans rs9825823 0.617 rs2083264 chr3:61074229 A/G cg14258366 chr7:41982794 NA 0.39 6.39 0.33 5.53e-10 Depressive symptom measurement or major depressive disorder; CRC cis rs796364 0.951 rs59695400 chr2:201021325 C/T cg23649088 chr2:200775458 C2orf69 -0.59 -6.57 -0.34 1.96e-10 Schizophrenia; CRC cis rs10504229 1.000 rs17217047 chr8:58180296 G/A cg02725872 chr8:58115012 NA -0.38 -6.43 -0.33 4.44e-10 Developmental language disorder (linguistic errors); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg09631055 chr7:157211098 NA 0.37 5.98 0.31 5.82e-9 Liver disease severity in Alagille syndrome; CRC cis rs4481887 1.000 rs10888360 chr1:248479282 G/A cg13385794 chr1:248469461 NA 0.41 7.2 0.37 4.23e-12 Common traits (Other); CRC trans rs4698169 0.510 rs675984 chr4:17123821 A/G cg25490145 chr17:80358850 C17orf101 -0.46 -7.28 -0.37 2.51e-12 Temperament (bipolar disorder); CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg04776910 chr19:58874233 ZNF497 0.47 6.62 0.34 1.44e-10 Anxiety disorder; CRC cis rs1215050 0.669 rs783962 chr4:98884473 G/A cg05340658 chr4:99064831 C4orf37 -0.5 -7.41 -0.38 1.05e-12 Waist-to-hip ratio adjusted for body mass index; CRC cis rs17270561 0.666 rs12209856 chr6:25793673 G/A cg16482183 chr6:26056742 HIST1H1C 0.72 9.32 0.46 1.73e-18 Iron status biomarkers; CRC cis rs35306767 0.807 rs12768348 chr10:899224 T/G cg20503657 chr10:835505 NA 1.21 14.81 0.63 2.26e-38 Eosinophil percentage of granulocytes; CRC cis rs597539 0.552 rs10896384 chr11:68720011 A/G cg06112835 chr11:68658793 MRPL21 -0.36 -5.79 -0.3 1.62e-8 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs736408 0.562 rs2072390 chr3:52780509 A/T cg18099408 chr3:52552593 STAB1 -0.47 -7.9 -0.4 4.12e-14 Bipolar disorder; CRC cis rs4332037 0.506 rs62442924 chr7:1989976 C/T cg21155852 chr7:2048760 MAD1L1 -0.48 -6.62 -0.34 1.43e-10 Bipolar disorder; CRC cis rs9818758 0.607 rs55873331 chr3:49597055 C/T cg01304814 chr3:48885189 PRKAR2A 0.79 6.01 0.31 4.79e-9 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; CRC cis rs7113874 0.569 rs11041983 chr11:8580619 A/G cg02811074 chr11:8615871 STK33 -0.34 -5.86 -0.31 1.14e-8 Body mass index in physically active individuals;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs4665809 0.590 rs2891496 chr2:26452605 G/A cg08067268 chr2:26466485 HADHB;HADHA 0.66 8.38 0.42 1.54e-15 Gut microbiome composition (summer); CRC cis rs765787 0.530 rs1706764 chr15:45524256 T/A cg24006582 chr15:45444508 DUOX1 -0.56 -8.48 -0.42 7.78e-16 Uric acid levels; CRC cis rs1707322 1.000 rs4660889 chr1:46297331 C/T cg06784218 chr1:46089804 CCDC17 0.52 9.15 0.45 5.92e-18 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs1448094 0.874 rs10779219 chr12:86322643 T/G cg19622623 chr12:86230825 RASSF9 -0.35 -5.69 -0.3 2.8e-8 Major depressive disorder; CRC cis rs853679 1.000 rs853679 chr6:28296863 C/A cg03623178 chr6:28175578 NA 0.64 6.81 0.35 4.77e-11 Depression; CRC cis rs116979167 0.575 rs1728649 chr7:105170570 A/G cg02135003 chr7:105160482 PUS7 -0.52 -7.96 -0.4 2.73e-14 Bipolar disorder (body mass index interaction); CRC cis rs7615952 0.576 rs66671308 chr3:125793526 T/G cg06494592 chr3:125709126 NA -0.57 -6.81 -0.35 4.74e-11 Blood pressure (smoking interaction); CRC cis rs4253772 0.591 rs11704614 chr22:46691936 A/G cg24881330 chr22:46731750 TRMU 0.59 5.79 0.3 1.66e-8 LDL cholesterol;Cholesterol, total; CRC cis rs9926296 0.744 rs164747 chr16:89708680 T/G cg01097406 chr16:89675127 NA 0.51 9.24 0.45 3.07e-18 Vitiligo; CRC cis rs9322817 0.607 rs7772567 chr6:105155782 C/A cg02098413 chr6:105308735 HACE1 -0.43 -8.36 -0.42 1.82e-15 Thyroid stimulating hormone; CRC cis rs16867321 0.951 rs13413574 chr2:181364491 A/G cg23363182 chr2:181467187 NA -0.49 -6.09 -0.32 3.16e-9 Obesity; CRC cis rs9322817 0.691 rs2499659 chr6:105286124 A/T cg02098413 chr6:105308735 HACE1 0.44 8.72 0.43 1.41e-16 Thyroid stimulating hormone; CRC cis rs1862618 0.853 rs252916 chr5:56121788 G/C cg03609598 chr5:56110824 MAP3K1 -0.84 -10.79 -0.51 1.93e-23 Initial pursuit acceleration; CRC cis rs1003719 0.715 rs2835675 chr21:38582815 G/A cg10648535 chr21:38446584 PIGP;TTC3 -0.46 -6.5 -0.34 3.03e-10 Eye color traits; CRC cis rs736408 0.812 rs2071506 chr3:52826276 T/C cg15147215 chr3:52552868 STAB1 -0.57 -8.99 -0.44 1.97e-17 Bipolar disorder; CRC cis rs17234274 0.622 rs2403823 chr11:23233044 C/G cg05245346 chr11:23248277 NA 0.34 5.63 0.3 3.79e-8 Cancer; CRC cis rs9467711 0.606 rs9379873 chr6:26402717 T/C cg14345882 chr6:26364793 BTN3A2 0.76 6.31 0.33 9.13e-10 Autism spectrum disorder or schizophrenia; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg03788995 chr7:148334381 NA -0.34 -5.99 -0.31 5.53e-9 Liver disease severity in Alagille syndrome; CRC cis rs6693567 0.565 rs6684939 chr1:150440563 G/A cg15654264 chr1:150340011 RPRD2 -0.4 -5.91 -0.31 8.48e-9 Migraine; CRC cis rs17270561 1.000 rs12211184 chr6:25823774 G/A cg17691542 chr6:26056736 HIST1H1C 0.84 9.52 0.46 3.83e-19 Iron status biomarkers; CRC cis rs12701220 0.894 rs13224488 chr7:1052353 C/A cg02733842 chr7:1102375 C7orf50 -0.83 -9.99 -0.48 1.11e-20 Bronchopulmonary dysplasia; CRC cis rs10883723 0.810 rs10786669 chr10:104256094 C/G cg22532475 chr10:104410764 TRIM8 -0.37 -6.81 -0.35 4.6e-11 Allergic disease (asthma, hay fever or eczema); CRC cis rs6840360 0.617 rs2724564 chr4:152349962 G/T cg09659197 chr4:152720779 NA 0.34 6.66 0.34 1.14e-10 Intelligence (multi-trait analysis); CRC trans rs941408 0.515 rs2110118 chr19:2775144 T/C cg22153745 chr1:153894579 GATAD2B -0.55 -7.62 -0.39 2.65e-13 Total cholesterol levels; CRC cis rs9788682 1.000 rs7163730 chr15:78814681 A/G cg06917634 chr15:78832804 PSMA4 -0.49 -6.01 -0.31 4.88e-9 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg00776808 chr7:107220968 BCAP29 0.42 6.64 0.34 1.32e-10 Liver disease severity in Alagille syndrome; CRC cis rs6840360 0.533 rs11099829 chr4:152727299 A/G cg09659197 chr4:152720779 NA -0.41 -8.39 -0.42 1.46e-15 Intelligence (multi-trait analysis); CRC cis rs2811415 0.597 rs67763343 chr3:127803163 C/T cg13719885 chr3:127795394 NA -0.4 -5.92 -0.31 8.11e-9 Lung function (FEV1/FVC); CRC trans rs2303319 0.504 rs55638078 chr2:162524997 T/C cg12500891 chr11:57225987 NA -0.68 -6.07 -0.32 3.55e-9 Cognitive function; CRC trans rs1656966 1.000 rs1656966 chr3:186466252 C/T cg21910613 chr1:27191950 NA 0.39 6.02 0.31 4.68e-9 Myopia (pathological); CRC trans rs61931739 0.534 rs2636082 chr12:34061848 T/A cg26384229 chr12:38710491 ALG10B 0.52 7.06 0.36 9.79e-12 Morning vs. evening chronotype; CRC cis rs6429082 0.818 rs704714 chr1:235632094 T/C cg26050004 chr1:235667680 B3GALNT2 0.59 8.05 0.41 1.56e-14 Adiposity; CRC cis rs9322193 0.772 rs7738696 chr6:150170121 A/G cg05861140 chr6:150128134 PCMT1 -0.42 -6.86 -0.35 3.38e-11 Lung cancer; CRC cis rs3741404 0.825 rs11603384 chr11:63949095 G/A cg18225595 chr11:63971243 STIP1 0.66 10.69 0.51 4.44e-23 Platelet count; CRC cis rs875971 0.862 rs6945775 chr7:65968974 G/A cg11764359 chr7:65958608 NA 0.61 9.57 0.47 2.61e-19 Aortic root size; CRC cis rs9322193 0.736 rs3828701 chr6:150112199 C/T cg07701084 chr6:150067640 NUP43 0.48 6.75 0.35 6.67e-11 Lung cancer; CRC trans rs7395662 0.581 rs10769445 chr11:48765594 A/C cg21153622 chr11:89784906 NA 0.44 7.09 0.36 8.08e-12 HDL cholesterol; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg07780777 chr8:59323842 UBXN2B 0.37 6.25 0.33 1.26e-9 Liver disease severity in Alagille syndrome; CRC cis rs9309711 0.506 rs9284794 chr2:3492052 G/A cg15506890 chr2:3487001 NA -0.55 -8.86 -0.44 5.14e-17 Neurofibrillary tangles; CRC cis rs9894429 1.000 rs11652797 chr17:79574124 A/G cg13777783 chr17:79615861 NA -0.29 -5.63 -0.3 3.91e-8 Eye color traits; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg04753786 chr19:48281744 SEPW1 0.41 6.08 0.32 3.3e-9 Liver disease severity in Alagille syndrome; CRC cis rs17253792 0.915 rs78498383 chr14:56177585 C/T cg01858014 chr14:56050164 KTN1 -0.79 -6.09 -0.32 3.09e-9 Putamen volume; CRC cis rs2658782 0.756 rs3019222 chr11:93079718 C/T cg15737290 chr11:93063684 CCDC67 0.54 7.72 0.39 1.39e-13 Pulmonary function decline; CRC trans rs1814175 0.645 rs28839231 chr11:50044292 G/T cg11707556 chr5:10655725 ANKRD33B -0.52 -10.16 -0.49 2.82e-21 Height; CRC cis rs1873147 1.000 rs12443295 chr15:63313666 C/T cg12160578 chr15:63334699 TPM1 -0.41 -5.81 -0.31 1.44e-8 Orofacial clefts; CRC trans rs11148252 0.716 rs1887360 chr13:52779166 A/G cg18335740 chr13:41363409 SLC25A15 0.52 7.52 0.38 5.24e-13 Lewy body disease; CRC cis rs57920188 0.640 rs4378174 chr1:4080885 C/T cg10510935 chr1:4059661 NA 0.38 5.7 0.3 2.69e-8 Interleukin-17 levels; CRC trans rs7618501 0.602 rs2301166 chr3:50148305 C/G cg21665057 chr3:196295764 WDR53;FBXO45 -0.58 -9.36 -0.46 1.25e-18 Intelligence (multi-trait analysis); CRC cis rs11098499 0.954 rs6847248 chr4:120225955 A/G cg09307838 chr4:120376055 NA 0.71 10.29 0.49 9.9e-22 Corneal astigmatism; CRC cis rs1799949 1.000 rs11649954 chr17:41420035 A/G cg19454999 chr17:41278357 BRCA1;NBR2 0.52 8.14 0.41 8.16e-15 Menopause (age at onset); CRC cis rs7677751 0.767 rs11133315 chr4:55082158 G/A cg00691999 chr4:55094011 PDGFRA 0.42 6.07 0.32 3.5e-9 Corneal astigmatism; CRC cis rs9916302 0.904 rs12452509 chr17:37574722 G/A cg00129232 chr17:37814104 STARD3 -0.54 -8.12 -0.41 9.26e-15 Glomerular filtration rate (creatinine); CRC cis rs995000 0.965 rs3850634 chr1:63050598 T/G cg19896129 chr1:63156450 NA 0.39 5.66 0.3 3.32e-8 Triglyceride levels; CRC cis rs514406 0.861 rs11206011 chr1:53235910 T/C cg24675658 chr1:53192096 ZYG11B 0.6 9.4 0.46 9.33e-19 Monocyte count; CRC cis rs362272 0.545 rs2749785 chr4:3325179 G/C cg02993699 chr4:3415135 RGS12 -0.39 -6.33 -0.33 7.89e-10 Serum sulfate level; CRC cis rs1448094 0.556 rs17279916 chr12:86170647 G/A cg02569458 chr12:86230093 RASSF9 0.5 8.2 0.41 5.51e-15 Major depressive disorder; CRC cis rs807669 0.903 rs2800974 chr22:19168087 C/T cg02655711 chr22:19163373 SLC25A1 0.94 19.06 0.72 4.17e-55 Metabolite levels; CRC cis rs13118159 0.801 rs1128427 chr4:1330759 T/C cg02018176 chr4:1364513 KIAA1530 0.44 7.13 0.37 6.31e-12 Longevity; CRC cis rs7399018 0.643 rs6580810 chr12:51610478 C/T cg12163867 chr12:51592794 POU6F1 -0.55 -8.13 -0.41 8.63e-15 Cisplatin-induced ototoxicity; CRC cis rs2797160 1.000 rs984040 chr6:126021277 A/G cg05901451 chr6:126070800 HEY2 0.38 5.88 0.31 9.94e-9 Endometrial cancer; CRC trans rs34156428 0.591 rs12577561 chr11:16806296 C/T cg02875130 chr19:1848745 REXO1 0.74 6.32 0.33 8.45e-10 Coronary artery disease; CRC cis rs34172651 0.517 rs3803716 chr16:24802325 C/T cg00339695 chr16:24857497 SLC5A11 0.43 8.83 0.44 6.56e-17 Intelligence (multi-trait analysis); CRC cis rs11785400 0.793 rs1137521 chr8:143739162 C/T cg24634471 chr8:143751801 JRK 0.47 6.41 0.33 5.17e-10 Schizophrenia; CRC trans rs2303319 0.504 rs62189051 chr2:162622318 G/A cg20024234 chr21:43431083 ZNF295 -0.66 -5.96 -0.31 6.5e-9 Cognitive function; CRC cis rs9549328 0.564 rs34556022 chr13:113617437 G/A cg20742385 chr13:113633654 MCF2L 0.56 9.5 0.46 4.54e-19 Systolic blood pressure; CRC cis rs7412746 0.597 rs868751 chr1:150669414 T/G cg18016565 chr1:150552671 MCL1 0.47 6.73 0.35 7.52e-11 Melanoma; CRC cis rs7552404 0.924 rs1251075 chr1:76190569 C/G cg10523679 chr1:76189770 ACADM 0.77 11.89 0.55 2.35e-27 Blood metabolite levels;Acylcarnitine levels; CRC cis rs6502050 0.835 rs7406220 chr17:80077850 T/C cg22110888 chr17:80059540 CCDC57 -0.41 -6.38 -0.33 6.13e-10 Life satisfaction; CRC cis rs7727544 0.669 rs113823725 chr5:131563501 C/G cg02033258 chr5:131593261 PDLIM4 0.36 6.77 0.35 6.11e-11 Blood metabolite levels; CRC trans rs9825823 0.617 rs2083264 chr3:61074229 A/G cg18167349 chr12:51664410 SMAGP 0.43 6.0 0.31 5.29e-9 Depressive symptom measurement or major depressive disorder; CRC cis rs8062405 0.964 rs7193733 chr16:28875482 A/G cg16576597 chr16:28551801 NUPR1 0.48 6.82 0.35 4.39e-11 Cognitive ability (multi-trait analysis);Cognitive ability; CRC cis rs10504229 0.775 rs55764517 chr8:58158238 G/A cg20607798 chr8:58055168 NA 0.46 5.69 0.3 2.79e-8 Developmental language disorder (linguistic errors); CRC cis rs7208859 0.673 rs11658344 chr17:29207745 G/T cg13385521 chr17:29058706 SUZ12P 0.65 7.71 0.39 1.51e-13 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs1881797 1.000 rs1881794 chr1:247682920 G/C cg21399703 chr1:247681439 NA -0.52 -9.57 -0.47 2.6e-19 Acute lymphoblastic leukemia (childhood); CRC cis rs9487051 0.735 rs459956 chr6:109524760 A/G cg01475377 chr6:109611718 NA -0.34 -5.88 -0.31 1.02e-8 Reticulocyte fraction of red cells; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg19472303 chr3:25705836 TOP2B 0.36 5.99 0.31 5.56e-9 Liver disease severity in Alagille syndrome; CRC cis rs1784581 0.651 rs1784593 chr6:162386096 A/T cg17173639 chr6:162384350 PARK2 -0.73 -12.2 -0.56 1.69e-28 Itch intensity from mosquito bite; CRC trans rs4263408 0.934 rs9683743 chr4:39703194 A/C cg09368805 chr7:5603387 NA -0.42 -6.17 -0.32 1.97e-9 Plasma amyloid beta peptide concentrations (ABx-40); CRC cis rs951366 0.622 rs11580015 chr1:205676088 G/C cg17178900 chr1:205818956 PM20D1 0.64 9.05 0.45 1.27e-17 Menarche (age at onset); CRC cis rs7255436 0.965 rs11666233 chr19:8452045 G/T cg10174797 chr19:8464628 RAB11B 0.46 8.02 0.4 1.85e-14 HDL cholesterol; CRC cis rs8060686 0.641 rs118035472 chr16:68242311 A/G cg26727032 chr16:67993705 SLC12A4 -0.52 -6.18 -0.32 1.87e-9 HDL cholesterol;Metabolic syndrome; CRC cis rs2228479 0.850 rs3785281 chr16:89824263 G/C cg19635926 chr16:89946313 TCF25 0.63 5.68 0.3 3.01e-8 Skin colour saturation; CRC cis rs8177253 0.763 rs12769 chr3:133474328 G/A cg01448562 chr3:133502909 NA -0.47 -7.48 -0.38 6.66e-13 Iron status biomarkers; CRC cis rs2836974 0.897 rs1571709 chr21:40553980 T/C cg11890956 chr21:40555474 PSMG1 1.12 20.81 0.75 5.55e-62 Cognitive function; CRC cis rs7289126 1.000 rs7290372 chr22:38628388 T/G cg25457927 chr22:38595422 NA -0.3 -5.89 -0.31 9.4e-9 Mammographic density (dense area);Percent mammographic density; CRC cis rs12936587 0.569 rs8073683 chr17:17555596 C/T cg04398451 chr17:18023971 MYO15A 0.35 5.91 0.31 8.77e-9 Hip circumference;Coronary artery disease or large artery stroke;Coronary heart disease;Coronary artery disease; CRC cis rs1799949 1.000 rs9646417 chr17:41424253 G/A cg19454999 chr17:41278357 BRCA1;NBR2 0.52 7.88 0.4 4.82e-14 Menopause (age at onset); CRC cis rs7517126 1.000 rs2878717 chr1:196843582 C/T cg13682187 chr1:196946512 CFHR5 -0.38 -6.27 -0.33 1.16e-9 Blood protein levels; CRC cis rs4964805 0.657 rs11111783 chr12:104188523 A/G cg02344784 chr12:104178138 NT5DC3 0.79 15.08 0.64 1.95e-39 Attention deficit hyperactivity disorder; CRC cis rs4243830 0.850 rs2412309 chr1:6603151 A/G cg22792644 chr1:6614718 TAS1R1;NOL9 -0.8 -9.66 -0.47 1.35e-19 Body mass index; CRC cis rs453193 0.800 rs186975 chr2:8442736 C/G cg12167548 chr2:8464763 NA -0.35 -6.37 -0.33 6.46e-10 Granulocyte percentage of myeloid white cells; CRC cis rs7811142 0.830 rs11769057 chr7:99964661 A/G cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.73 9.99 0.48 1.07e-20 Platelet count; CRC cis rs7772486 0.754 rs9399567 chr6:146147295 C/T cg13319975 chr6:146136371 FBXO30 -0.46 -6.95 -0.36 2.01e-11 Lobe attachment (rater-scored or self-reported); CRC cis rs9858542 0.951 rs1800668 chr3:49395757 G/A cg03060546 chr3:49711283 APEH -0.48 -6.81 -0.35 4.64e-11 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs6754311 0.773 rs188680 chr2:136630989 A/G cg15123519 chr2:136567270 LCT 0.35 6.87 0.35 3.17e-11 Mosquito bite size; CRC cis rs11948739 0.501 rs2419755 chr5:130252835 A/G cg08523029 chr5:130500466 HINT1 0.42 5.69 0.3 2.86e-8 Pediatric bone mineral content (hip); CRC cis rs875971 0.862 rs778686 chr7:65835910 C/T cg18252515 chr7:66147081 NA -0.4 -5.78 -0.3 1.72e-8 Aortic root size; CRC cis rs1799949 0.930 rs35292991 chr17:41334016 C/A cg25072359 chr17:41440525 NA 0.44 6.53 0.34 2.54e-10 Menopause (age at onset); CRC cis rs897984 0.762 rs4889599 chr16:30968589 C/T cg02466173 chr16:30829666 NA 0.62 9.3 0.46 1.96e-18 Dementia with Lewy bodies; CRC cis rs4481887 0.821 rs7515408 chr1:248425738 C/T cg00666640 chr1:248458726 OR2T12 0.6 10.43 0.5 3.36e-22 Common traits (Other); CRC cis rs642858 1.000 rs4895579 chr6:140303401 G/A cg27524944 chr6:140295369 NA -0.36 -5.95 -0.31 6.76e-9 Type 2 diabetes; CRC cis rs2346160 0.836 rs206991 chr6:167699378 A/G cg27333441 chr6:167680455 NA -0.4 -6.57 -0.34 2.01e-10 Parental extreme longevity (95 years and older); CRC cis rs7811142 1.000 rs67239991 chr7:100046504 A/G cg00814883 chr7:100076585 TSC22D4 -0.72 -9.44 -0.46 7.01e-19 Platelet count; CRC cis rs7666738 0.830 rs13111977 chr4:98953813 G/A cg17366294 chr4:99064904 C4orf37 0.43 7.34 0.38 1.69e-12 Colonoscopy-negative controls vs population controls; CRC cis rs6952808 0.510 rs13227554 chr7:2048220 G/C cg22963979 chr7:1858916 MAD1L1 0.44 6.85 0.35 3.57e-11 Bipolar disorder and schizophrenia; CRC cis rs911555 0.617 rs7156036 chr14:103908142 A/G cg12935359 chr14:103987150 CKB 0.56 9.13 0.45 7.33e-18 Intelligence (multi-trait analysis); CRC cis rs6502050 0.830 rs7219036 chr17:80161119 T/C cg13198984 chr17:80129470 CCDC57 0.42 7.39 0.38 1.19e-12 Life satisfaction; CRC cis rs2204008 0.685 rs4556621 chr12:38187236 C/A cg26384229 chr12:38710491 ALG10B 0.71 9.38 0.46 1.08e-18 Bladder cancer; CRC cis rs2303759 0.918 rs4802597 chr19:49872085 C/T cg24324837 chr19:49891574 CCDC155 0.52 7.46 0.38 7.72e-13 Multiple sclerosis; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg05477027 chr19:46295590 DMWD 0.54 7.02 0.36 1.26e-11 Thyroid stimulating hormone; CRC cis rs3736594 0.513 rs59876138 chr2:27792323 A/C cg27432699 chr2:27873401 GPN1 0.64 8.5 0.42 6.81e-16 Fasting blood glucose;Fasting blood glucose (BMI interaction); CRC cis rs8014204 0.604 rs11159109 chr14:75389074 G/A cg06998765 chr14:75389618 RPS6KL1 -0.26 -6.22 -0.32 1.52e-9 Caffeine consumption; CRC cis rs992157 0.835 rs13005100 chr2:219151767 C/T cg00012203 chr2:219082015 ARPC2 -0.47 -7.08 -0.36 8.67e-12 Colorectal cancer; CRC cis rs73206853 0.764 rs7966591 chr12:110644045 G/A cg12870014 chr12:110450643 ANKRD13A 0.82 10.62 0.51 7.55e-23 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC cis rs6756513 0.520 rs6546560 chr2:70173690 A/G cg02498382 chr2:70120550 SNRNP27 -0.49 -7.99 -0.4 2.24e-14 Breast cancer;Platelet count; CRC trans rs9341835 0.772 rs9294197 chr6:64135648 A/G cg13657004 chr13:50234944 EBPL -0.36 -6.03 -0.32 4.42e-9 Schizophrenia; CRC trans rs4958351 0.719 rs74739622 chr5:153221968 T/A cg03074421 chr9:126102037 NA -0.38 -6.01 -0.31 4.88e-9 Asparaginase hypersensitivity in acute lymphoblastic leukemia; CRC cis rs1943345 0.530 rs501155 chr11:82919893 G/T cg07047830 chr11:82868014 PCF11 0.42 6.04 0.32 4.23e-9 Obesity-related traits; CRC cis rs9549367 0.713 rs56002882 chr13:113830694 T/C cg24300038 chr13:113819356 PROZ -0.46 -5.62 -0.3 4.01e-8 Platelet distribution width; CRC cis rs921968 0.643 rs471846 chr2:219432237 C/T cg02176678 chr2:219576539 TTLL4 0.48 7.88 0.4 4.94e-14 Mean corpuscular hemoglobin concentration; CRC trans rs3001167 1.000 rs10921612 chr1:194548819 T/G cg22004422 chr13:113740730 MCF2L -0.53 -5.97 -0.31 6.02e-9 Obesity-related traits; CRC cis rs992157 0.835 rs10932768 chr2:219146199 T/A cg00012203 chr2:219082015 ARPC2 -0.47 -7.13 -0.37 6.22e-12 Colorectal cancer; CRC cis rs7247513 0.897 rs12972944 chr19:12713808 G/A cg01871581 chr19:12707946 ZNF490 -0.77 -12.82 -0.58 8.94e-31 Bipolar disorder; CRC cis rs1799949 1.000 rs4534897 chr17:41431808 A/G cg01879757 chr17:41196368 BRCA1 -0.44 -6.68 -0.35 9.92e-11 Menopause (age at onset); CRC cis rs4481887 0.927 rs6666903 chr1:248465582 T/A cg13385794 chr1:248469461 NA 0.37 6.49 0.34 3.15e-10 Common traits (Other); CRC cis rs270601 0.770 rs10463891 chr5:131597392 C/T cg24060327 chr5:131705240 SLC22A5 0.38 5.95 0.31 6.69e-9 Acylcarnitine levels; CRC cis rs7208859 0.623 rs73269913 chr17:29092183 T/C cg01831904 chr17:28903510 LRRC37B2 -0.62 -6.41 -0.33 5.06e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs2046867 0.774 rs1393585 chr3:72886722 A/G cg25664220 chr3:72788482 NA -0.47 -6.69 -0.35 9.59e-11 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; CRC cis rs270601 0.683 rs81598 chr5:131587960 C/G cg22638593 chr5:131593259 PDLIM4 0.5 8.67 0.43 1.95e-16 Acylcarnitine levels; CRC cis rs6546324 0.625 rs6746394 chr2:67845021 A/C cg15745817 chr2:67799979 NA -0.57 -9.66 -0.47 1.37e-19 Endometriosis; CRC trans rs10504229 1.000 rs17805602 chr8:58179915 A/G cg04077850 chr5:125800366 GRAMD3 0.37 6.27 0.33 1.15e-9 Developmental language disorder (linguistic errors); CRC cis rs7826238 0.509 rs2948288 chr8:8115304 A/G cg06636001 chr8:8085503 FLJ10661 0.67 10.71 0.51 3.67e-23 Systolic blood pressure; CRC cis rs7618915 0.571 rs67539070 chr3:52711974 T/C cg18099408 chr3:52552593 STAB1 -0.44 -7.22 -0.37 3.66e-12 Bipolar disorder; CRC cis rs1712517 0.771 rs10883857 chr10:105127587 A/C cg05636881 chr10:105038444 INA -0.44 -7.4 -0.38 1.14e-12 Migraine; CRC cis rs12681288 0.676 rs2600514 chr8:994175 G/A cg04851639 chr8:1020857 NA -0.4 -8.11 -0.41 1.02e-14 Schizophrenia; CRC cis rs58688157 0.549 rs11246192 chr11:572473 T/C cg09218773 chr11:619014 MUPCDH -0.36 -5.79 -0.3 1.64e-8 Systemic lupus erythematosus; CRC cis rs9486719 1.000 rs34236778 chr6:96884556 C/A cg06623918 chr6:96969491 KIAA0776 -0.81 -9.51 -0.46 4.17e-19 Migraine;Coronary artery disease; CRC cis rs2239547 0.618 rs13083728 chr3:52868445 G/A cg15147215 chr3:52552868 STAB1 -0.43 -6.05 -0.32 3.92e-9 Schizophrenia; CRC cis rs9318086 0.935 rs9652081 chr13:24435510 C/T cg25267304 chr13:24462978 PCOTH;MIPEP -0.59 -9.62 -0.47 1.79e-19 Myopia (pathological); CRC cis rs1552244 0.572 rs3894322 chr3:10168965 G/A cg16606324 chr3:10149918 C3orf24 0.66 7.77 0.39 9.99e-14 Alzheimer's disease; CRC cis rs7584330 0.780 rs2292884 chr2:238443226 A/G cg14458575 chr2:238380390 NA 0.52 8.77 0.44 9.83e-17 Prostate cancer; CRC cis rs4713118 0.869 rs6456802 chr6:27698355 A/G cg08798685 chr6:27730294 NA -0.42 -6.26 -0.33 1.23e-9 Parkinson's disease; CRC cis rs9733 0.526 rs11204698 chr1:150659545 G/A cg15448220 chr1:150897856 SETDB1 0.47 6.77 0.35 6.05e-11 Tonsillectomy; CRC trans rs2018683 0.803 rs12700920 chr7:28984924 A/G cg19402173 chr7:128379420 CALU -0.57 -8.54 -0.43 5.08e-16 Response to irinotecan and platinum-based chemotherapy in non-small-cell lung cancer; CRC cis rs12325245 0.536 rs12925676 chr16:58625326 C/T cg26666090 chr16:58549219 SETD6 0.94 6.49 0.34 3.19e-10 Schizophrenia; CRC cis rs12477438 1.000 rs17760953 chr2:99859863 G/A cg14399236 chr2:99771627 LIPT1;TSGA10 -0.71 -8.93 -0.44 3.09e-17 Chronic sinus infection; CRC cis rs10876993 0.928 rs1628552 chr12:58082142 C/T cg18357645 chr12:58087776 OS9 0.6 8.4 0.42 1.31e-15 Celiac disease or Rheumatoid arthritis; CRC cis rs1865760 0.516 rs9358903 chr6:26061949 A/C cg17691542 chr6:26056736 HIST1H1C 0.55 8.44 0.42 1.06e-15 Height; CRC cis rs6502050 0.805 rs7406858 chr17:80080623 G/A cg11859384 chr17:80120422 CCDC57 0.37 5.77 0.3 1.85e-8 Life satisfaction; CRC cis rs959260 0.557 rs12936583 chr17:73304710 A/C cg14668889 chr17:73230827 NUP85 0.49 6.96 0.36 1.84e-11 Systemic lupus erythematosus; CRC cis rs2576037 0.542 rs4630643 chr18:44508142 G/A cg23996704 chr18:44553084 KATNAL2 -0.36 -6.89 -0.36 2.78e-11 Personality dimensions; CRC cis rs2933343 0.621 rs789241 chr3:128585752 G/A cg11901034 chr3:128598214 ACAD9 -0.55 -8.07 -0.41 1.36e-14 IgG glycosylation; CRC cis rs7605827 0.930 rs2111454 chr2:15522331 G/A cg19274914 chr2:15703543 NA 0.39 5.9 0.31 8.92e-9 Educational attainment (years of education); CRC cis rs4481887 0.893 rs4297335 chr1:248473421 C/T cg13385794 chr1:248469461 NA 0.38 6.65 0.34 1.26e-10 Common traits (Other); CRC trans rs9936075 0.553 rs13337052 chr16:7373470 C/T cg11804928 chr17:38220298 THRA -0.35 -6.19 -0.32 1.83e-9 Platelet-derived growth factor BB levels; CRC cis rs11105298 0.891 rs4842654 chr12:89834428 T/A cg08166232 chr12:89918718 WDR51B;GALNT4 -0.61 -7.74 -0.39 1.27e-13 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; CRC cis rs9515201 1.000 rs9515201 chr13:111040798 A/C cg11096515 chr13:111062287 COL4A2 -0.32 -5.89 -0.31 9.53e-9 White matter hyperintensity burden; CRC trans rs11098499 0.866 rs13105020 chr4:120285688 G/T cg25214090 chr10:38739885 LOC399744 0.6 9.61 0.47 2e-19 Corneal astigmatism; CRC cis rs11098499 0.865 rs3956464 chr4:120256764 T/C cg09307838 chr4:120376055 NA 0.62 9.63 0.47 1.68e-19 Corneal astigmatism; CRC cis rs853679 0.517 rs9393901 chr6:28136797 A/G cg23161317 chr6:28129485 ZNF389 0.53 6.43 0.33 4.52e-10 Depression; CRC cis rs123509 0.687 rs73075297 chr3:42832466 A/G cg12982090 chr3:42733453 KBTBD5 -0.56 -6.82 -0.35 4.36e-11 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg07932290 chr14:74252976 C14orf43 0.44 6.09 0.32 3.09e-9 Response to antipsychotic treatment; CRC cis rs9905704 0.881 rs12942879 chr17:56861253 G/A cg12560992 chr17:57184187 TRIM37 0.52 7.27 0.37 2.56e-12 Testicular germ cell tumor; CRC cis rs9287719 0.967 rs715247 chr2:10736291 A/G cg00105475 chr2:10696890 NA 0.45 7.3 0.37 2.19e-12 Prostate cancer; CRC cis rs950169 0.922 rs12911223 chr15:84831671 G/A cg17507749 chr15:85114479 UBE2QP1 -0.75 -11.04 -0.52 2.5300000000000002e-24 Schizophrenia; CRC cis rs2857891 0.817 rs2239730 chr11:6977175 G/C cg12728517 chr11:6947552 ZNF215 0.49 5.77 0.3 1.84e-8 Response to cytadine analogues (cytosine arabinoside); CRC cis rs910316 0.967 rs7146523 chr14:75659880 T/C cg08847533 chr14:75593920 NEK9 -0.83 -14.35 -0.62 1.38e-36 Height; CRC cis rs939584 0.932 rs13387091 chr2:650980 G/A cg03610516 chr2:642275 NA -0.43 -5.73 -0.3 2.29e-8 Body mass index; CRC cis rs8077889 0.871 rs11079838 chr17:41898971 G/A cg25876840 chr17:41920477 NA 0.51 7.63 0.39 2.62e-13 Triglycerides; CRC cis rs11122272 0.735 rs2491403 chr1:231511185 C/T cg06096015 chr1:231504339 EGLN1 0.4 5.95 0.31 6.7e-9 Hemoglobin concentration; CRC cis rs17401966 0.540 rs1467653 chr1:10413123 A/G cg19773385 chr1:10388646 KIF1B 0.45 6.93 0.36 2.22e-11 Hepatocellular carcinoma; CRC cis rs7517126 1.000 rs13375144 chr1:196841690 C/T cg13682187 chr1:196946512 CFHR5 -0.37 -6.02 -0.32 4.6e-9 Blood protein levels; CRC cis rs728616 0.867 rs1923534 chr10:81710485 A/G cg05935833 chr10:81318306 SFTPA2 -0.73 -8.0 -0.4 2.14e-14 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs11098499 0.866 rs12499602 chr4:120284387 T/A cg09307838 chr4:120376055 NA 0.68 10.53 0.5 1.51e-22 Corneal astigmatism; CRC cis rs11758351 0.518 rs79922979 chr6:26224975 A/G cg08260959 chr6:26240920 HIST1H4F -0.35 -5.62 -0.3 4.11e-8 Gout;Renal underexcretion gout; CRC cis rs4969178 0.965 rs12944051 chr17:76395856 C/T cg05887092 chr17:76393375 PGS1 -0.55 -9.97 -0.48 1.28e-20 HDL cholesterol levels; CRC cis rs13191362 1.000 rs13213408 chr6:162998049 A/T cg06582575 chr6:163149167 PACRG;PARK2 0.76 10.43 0.5 3.45e-22 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs78456975 0.689 rs13391992 chr2:1542153 G/A cg01028140 chr2:1542097 TPO -0.56 -6.18 -0.32 1.94e-9 Placebo response in major depressive disorder (% change in symptom score); CRC cis rs734999 0.588 rs2764842 chr1:2529192 A/G cg18854424 chr1:2615690 NA -0.42 -8.07 -0.41 1.3e-14 Ulcerative colitis; CRC cis rs7917772 0.582 rs10883744 chr10:104347247 A/G cg11453585 chr10:104263688 ACTR1A;SUFU 0.82 15.29 0.64 3.08e-40 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC cis rs9372498 0.536 rs9481833 chr6:118919631 G/A cg18833306 chr6:118973337 C6orf204 0.44 5.71 0.3 2.54e-8 Diastolic blood pressure; CRC trans rs11088226 0.681 rs11702499 chr21:33938565 C/T cg09050820 chr6:167586206 TCP10L2 0.81 8.55 0.43 4.61e-16 Gastritis; CRC cis rs6840360 0.593 rs10016160 chr4:152693998 A/G cg09659197 chr4:152720779 NA 0.41 8.44 0.42 1.06e-15 Intelligence (multi-trait analysis); CRC cis rs6121246 0.865 rs6089055 chr20:30324045 C/T cg13852791 chr20:30311386 BCL2L1 0.64 9.78 0.47 5.44e-20 Mean corpuscular hemoglobin; CRC cis rs4400599 0.642 rs4072431 chr1:154167116 A/G cg26808167 chr1:154192205 UBAP2L;C1orf43 -0.37 -5.71 -0.3 2.48e-8 Platelet distribution width; CRC cis rs6988985 0.728 rs4736311 chr8:143952700 A/G cg10324643 chr8:143916377 GML 0.37 6.05 0.32 4.01e-9 Plasma androstenedione levels in resected early stage-receptor positive breast cancer; CRC cis rs12926788 0.546 rs200537 chr16:24747787 G/C cg06028605 chr16:24865363 SLC5A11 -0.59 -9.89 -0.48 2.35e-20 Ejection fraction in Tripanosoma cruzi seropositivity; CRC trans rs916888 0.610 rs199446 chr17:44813169 G/A cg01341218 chr17:43662625 NA -0.58 -7.39 -0.38 1.19e-12 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs10540 1.000 rs12801271 chr11:508720 C/T cg03576123 chr11:487126 PTDSS2 -1.04 -10.78 -0.51 2.09e-23 Body mass index; CRC cis rs3744061 0.569 rs2240769 chr17:74718155 C/T cg13533061 chr17:74712429 JMJD6 -0.46 -6.96 -0.36 1.86e-11 Retinal arteriolar caliber; CRC cis rs6951245 1.000 rs2363286 chr7:1091625 A/G cg20603222 chr7:1096387 C7orf50;GPR146 -0.69 -8.53 -0.43 5.49e-16 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs9325144 0.505 rs7955162 chr12:38711658 G/A cg13010199 chr12:38710504 ALG10B 0.47 6.63 0.34 1.42e-10 Morning vs. evening chronotype; CRC cis rs6089584 0.854 rs6061985 chr20:60622362 T/C cg06108461 chr20:60628389 TAF4 -0.93 -16.5 -0.67 5.26e-45 Body mass index; CRC cis rs2811415 0.627 rs13313895 chr3:127752084 T/C cg13719885 chr3:127795394 NA -0.37 -5.67 -0.3 3.19e-8 Lung function (FEV1/FVC); CRC cis rs6912958 0.781 rs9450732 chr6:88249826 G/A cg12350822 chr6:88032061 C6orf162;GJB7 -0.33 -6.36 -0.33 6.84e-10 Monocyte percentage of white cells; CRC cis rs2839186 0.656 rs8128380 chr21:47665693 C/T cg09417038 chr21:47716443 C21orf57 -0.4 -6.45 -0.34 3.93e-10 Testicular germ cell tumor; CRC cis rs6484504 0.576 rs9971609 chr11:31434104 C/T cg14844989 chr11:31128820 NA 0.34 5.93 0.31 7.55e-9 Red blood cell count; CRC cis rs6952808 0.609 rs6944877 chr7:1952582 T/G cg21782813 chr7:2030301 MAD1L1 0.4 7.38 0.38 1.33e-12 Bipolar disorder and schizophrenia; CRC cis rs6860806 0.507 rs183898 chr5:131716902 C/G cg24060327 chr5:131705240 SLC22A5 0.52 7.73 0.39 1.3e-13 Breast cancer; CRC cis rs7538876 0.967 rs2800696 chr1:17730238 A/T cg01904812 chr1:17746340 RCC2 0.34 5.73 0.3 2.28e-8 Basal cell carcinoma; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg05059663 chr17:13972631 COX10 0.44 6.77 0.35 5.94e-11 Intelligence (multi-trait analysis); CRC cis rs11719291 0.833 rs34037363 chr3:48821036 C/T cg07636037 chr3:49044803 WDR6 -0.81 -6.66 -0.34 1.14e-10 Cognitive function; CRC cis rs1153858 1.000 rs4775906 chr15:45638294 C/T cg10760299 chr15:45669010 GATM 0.5 7.99 0.4 2.37e-14 Homoarginine levels; CRC cis rs1707322 0.826 rs10890349 chr1:46249955 T/C cg03146154 chr1:46216737 IPP 0.62 8.87 0.44 4.65e-17 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs3733585 0.579 rs4235356 chr4:10123106 G/C cg11266682 chr4:10021025 SLC2A9 -0.49 -9.11 -0.45 7.95e-18 Cleft plate (environmental tobacco smoke interaction); CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg06650216 chr7:138145531 TRIM24 0.46 6.4 0.33 5.44e-10 Anxiety disorder; CRC cis rs17270561 0.636 rs7453371 chr6:25719256 A/G cg17691542 chr6:26056736 HIST1H1C 0.64 8.21 0.41 5.1e-15 Iron status biomarkers; CRC cis rs2153535 0.580 rs9379206 chr6:8458021 C/A cg21535247 chr6:8435926 SLC35B3 0.51 7.9 0.4 4.36e-14 Motion sickness; CRC cis rs6500395 0.788 rs12446280 chr16:48651171 G/T cg04672837 chr16:48644449 N4BP1 0.41 5.76 0.3 1.89e-8 Response to tocilizumab in rheumatoid arthritis; CRC cis rs9911578 0.692 rs411988 chr17:56709034 G/A cg12560992 chr17:57184187 TRIM37 0.75 12.28 0.56 8.4e-29 Intelligence (multi-trait analysis); CRC cis rs2274273 0.840 rs943590 chr14:55738596 T/C cg23234261 chr14:55582407 NA -0.28 -5.91 -0.31 8.74e-9 Protein biomarker; CRC cis rs728616 0.867 rs7080405 chr10:81901943 G/C cg05935833 chr10:81318306 SFTPA2 -0.71 -7.95 -0.4 2.95e-14 Chronic obstructive pulmonary disease-related biomarkers; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg23712980 chr20:30795555 POFUT1;PLAGL2 0.45 6.17 0.32 2e-9 Anxiety disorder; CRC cis rs597539 0.652 rs496616 chr11:68672800 G/C cg04772025 chr11:68637568 NA 0.49 7.55 0.38 4.2e-13 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC trans rs1814175 0.645 rs28627251 chr11:50048125 G/T cg15704280 chr7:45808275 SEPT13 -0.94 -17.39 -0.69 1.77e-48 Height; CRC cis rs1448094 0.967 rs11117116 chr12:86331087 A/T cg19622623 chr12:86230825 RASSF9 -0.35 -5.69 -0.3 2.8e-8 Major depressive disorder; CRC cis rs7937682 0.924 rs875258 chr11:111530607 C/A cg09085632 chr11:111637200 PPP2R1B -1.0 -20.15 -0.74 2.29e-59 Primary sclerosing cholangitis; CRC cis rs1957429 0.901 rs3813423 chr14:65347475 C/A cg23373153 chr14:65346875 NA 0.79 8.25 0.41 3.9e-15 Pediatric areal bone mineral density (radius); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg05776763 chr14:75348391 DLST 0.43 6.22 0.32 1.49e-9 Intelligence (multi-trait analysis); CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg01690029 chr3:125314090 OSBPL11 0.46 6.27 0.33 1.14e-9 Anxiety disorder; CRC cis rs11098499 0.826 rs4472123 chr4:120236630 T/A cg09307838 chr4:120376055 NA 0.59 9.1 0.45 8.92e-18 Corneal astigmatism; CRC cis rs1005277 0.563 rs2800550 chr10:38482929 T/C cg25427524 chr10:38739819 LOC399744 -0.77 -13.75 -0.6 2.69e-34 Extrinsic epigenetic age acceleration; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg16551665 chr17:30814028 CDK5R1 0.42 6.14 0.32 2.37e-9 Intelligence (multi-trait analysis); CRC cis rs2180341 0.618 rs11154398 chr6:127654281 C/A cg24812749 chr6:127587940 RNF146 0.64 9.59 0.47 2.37e-19 Breast cancer; CRC cis rs6570726 0.935 rs419850 chr6:145827281 A/G cg05347473 chr6:146136440 FBXO30 0.37 5.85 0.31 1.17e-8 Lobe attachment (rater-scored or self-reported); CRC cis rs2404602 0.716 rs1874944 chr15:76863928 A/G cg22467129 chr15:76604101 ETFA -0.39 -6.43 -0.33 4.59e-10 Blood metabolite levels; CRC cis rs66573146 0.831 rs68111914 chr4:6986677 C/T cg00086871 chr4:6988644 TBC1D14 1.03 8.74 0.43 1.19e-16 Granulocyte percentage of myeloid white cells; CRC trans rs61931739 0.500 rs2389269 chr12:34034179 C/T cg26384229 chr12:38710491 ALG10B 0.53 6.72 0.35 8.12e-11 Morning vs. evening chronotype; CRC cis rs6815814 0.808 rs4833093 chr4:38789740 G/T cg06935464 chr4:38784597 TLR10 0.69 8.95 0.44 2.7e-17 Breast cancer; CRC trans rs6956675 0.831 rs4718878 chr7:62656497 T/C cg01314568 chr7:57830625 NA -0.62 -8.88 -0.44 4.38e-17 Obesity-related traits; CRC cis rs6426558 0.537 rs4351610 chr1:227325245 A/G cg10327440 chr1:227177885 CDC42BPA -0.47 -6.96 -0.36 1.88e-11 Neutrophil percentage of white cells; CRC cis rs9768139 0.708 rs10262596 chr7:158114495 G/A cg23298862 chr7:158159286 PTPRN2 0.39 6.16 0.32 2.1e-9 Calcium levels; CRC cis rs34779708 0.966 rs12765038 chr10:35416513 G/C cg03585969 chr10:35415529 CREM 0.59 7.8 0.39 8.43e-14 Inflammatory bowel disease;Crohn's disease; CRC cis rs9916302 0.904 rs7208274 chr17:37513796 C/T cg15445000 chr17:37608096 MED1 -0.44 -9.71 -0.47 9.25e-20 Glomerular filtration rate (creatinine); CRC cis rs9611565 0.659 rs116959331 chr22:41932774 A/G cg06481639 chr22:41940642 POLR3H -0.52 -5.97 -0.31 6.25e-9 Vitiligo; CRC cis rs10504229 1.000 rs68076606 chr8:58191271 A/G cg24829409 chr8:58192753 C8orf71 -0.68 -11.34 -0.53 2.27e-25 Developmental language disorder (linguistic errors); CRC cis rs9527 0.640 rs35195396 chr10:104928770 T/A cg15744005 chr10:104629667 AS3MT -0.31 -6.18 -0.32 1.91e-9 Arsenic metabolism; CRC cis rs17234274 0.644 rs1482713 chr11:23216886 A/G cg05245346 chr11:23248277 NA 0.36 5.92 0.31 8.22e-9 Cancer; CRC cis rs6460942 0.591 rs7800823 chr7:12378697 G/T cg06484146 chr7:12443880 VWDE -0.48 -6.96 -0.36 1.82e-11 Coronary artery disease; CRC trans rs1656966 1.000 rs1656966 chr3:186466252 C/T cg24123057 chr8:11660089 FDFT1 0.41 6.47 0.34 3.62e-10 Myopia (pathological); CRC cis rs514406 0.560 rs1889033 chr1:53211887 A/G cg24675658 chr1:53192096 ZYG11B 0.65 10.06 0.49 6.2e-21 Monocyte count; CRC cis rs2197308 0.626 rs6581156 chr12:37858731 C/A cg13010199 chr12:38710504 ALG10B -0.49 -7.21 -0.37 3.95e-12 Morning vs. evening chronotype; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg02562419 chr6:159049626 TMEM181 -0.4 -6.37 -0.33 6.46e-10 Liver disease severity in Alagille syndrome; CRC cis rs10751667 1.000 rs7394449 chr11:962190 T/C cg01483505 chr11:975446 AP2A2 0.41 6.23 0.33 1.39e-9 Alzheimer's disease (late onset); CRC trans rs7613875 0.620 rs7634441 chr3:50071677 G/A cg21659725 chr3:3221576 CRBN -0.46 -6.83 -0.35 4.02e-11 Body mass index; CRC cis rs6502050 0.805 rs7406682 chr17:80084368 C/T cg22110888 chr17:80059540 CCDC57 -0.41 -6.39 -0.33 5.58e-10 Life satisfaction; CRC cis rs6604026 0.740 rs2893225 chr1:93368496 G/C cg17283838 chr1:93427260 FAM69A -0.5 -6.83 -0.35 4.09e-11 Multiple sclerosis; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg03729431 chr17:15848264 ADORA2B 0.43 5.99 0.31 5.42e-9 Anxiety disorder; CRC cis rs853679 1.000 rs7740487 chr6:28216486 C/G cg06470822 chr6:28175283 NA 0.69 6.48 0.34 3.33e-10 Depression; CRC cis rs1707322 0.647 rs6686944 chr1:46156308 G/T cg06784218 chr1:46089804 CCDC17 0.66 12.54 0.57 9.56e-30 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs7703744 0.634 rs17145248 chr5:118685011 C/T cg23985447 chr5:118691066 TNFAIP8 0.4 5.64 0.3 3.74e-8 Lobe attachment (rater-scored or self-reported); CRC cis rs834811 0.602 rs6950690 chr7:135890568 G/A cg01726295 chr7:135938950 NA 0.35 6.08 0.32 3.32e-9 Post-traumatic stress disorder; CRC cis rs9291683 0.546 rs4575994 chr4:9997979 G/A cg11266682 chr4:10021025 SLC2A9 0.47 9.51 0.46 4.13e-19 Bone mineral density; CRC cis rs801193 1.000 rs4717310 chr7:66161007 C/T cg25985355 chr7:65971099 NA -0.32 -5.72 -0.3 2.4e-8 Aortic root size; CRC cis rs1018836 0.923 rs7013893 chr8:91563137 G/A cg16814680 chr8:91681699 NA -0.73 -11.54 -0.54 4.16e-26 Ejection fraction in Tripanosoma cruzi seropositivity; CRC cis rs4713118 0.869 rs2056925 chr6:27690905 A/G cg06470822 chr6:28175283 NA 0.68 9.51 0.46 4.09e-19 Parkinson's disease; CRC cis rs1707322 0.963 rs4660900 chr1:46419605 T/C cg03146154 chr1:46216737 IPP 0.51 7.12 0.37 6.96e-12 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs11785400 0.753 rs9773415 chr8:143731170 G/A cg24634471 chr8:143751801 JRK 0.53 7.29 0.37 2.32e-12 Schizophrenia; CRC cis rs9814567 1.000 rs17694011 chr3:134213981 T/C cg06541857 chr3:134203789 ANAPC13;CEP63 -0.41 -6.22 -0.32 1.48e-9 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs9649213 0.593 rs13232181 chr7:97935671 C/G cg24562669 chr7:97807699 LMTK2 0.4 6.61 0.34 1.55e-10 Prostate cancer (SNP x SNP interaction); CRC cis rs4588572 0.643 rs10068686 chr5:77795220 C/T cg11547950 chr5:77652471 NA -0.55 -7.63 -0.39 2.51e-13 Triglycerides; CRC cis rs2836974 0.966 rs2836977 chr21:40666066 T/C cg11890956 chr21:40555474 PSMG1 1.08 18.07 0.71 3.42e-51 Cognitive function; CRC cis rs7202877 0.706 rs247423 chr16:75456631 C/A cg03315344 chr16:75512273 CHST6 -0.52 -6.19 -0.32 1.84e-9 Type 2 diabetes;Type 1 diabetes; CRC cis rs8060686 0.920 rs2271293 chr16:67902070 A/G cg27539214 chr16:67997921 SLC12A4 0.5 6.37 0.33 6.54e-10 HDL cholesterol;Metabolic syndrome; CRC cis rs7399018 0.739 rs6580811 chr12:51612501 T/C cg20712883 chr12:51590929 POU6F1 0.65 8.33 0.42 2.18e-15 Cisplatin-induced ototoxicity; CRC cis rs554111 0.891 rs646786 chr1:21054726 A/G cg08890418 chr1:21044141 KIF17 0.32 6.02 0.32 4.56e-9 Facial morphology (factor 17, height of vermillion upper lip); CRC trans rs4363385 0.720 rs11205150 chr1:152959266 C/T cg03800765 chr3:11313984 ATG7 -0.41 -6.09 -0.32 3.22e-9 Inflammatory skin disease; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg03469472 chr1:173991446 NA 0.49 6.44 0.33 4.25e-10 Thyroid stimulating hormone; CRC cis rs10504229 0.683 rs7835498 chr8:58129780 A/C cg24829409 chr8:58192753 C8orf71 -0.55 -8.03 -0.4 1.71e-14 Developmental language disorder (linguistic errors); CRC cis rs62229266 0.563 rs6517325 chr21:37434978 T/C cg12218747 chr21:37451666 NA -0.37 -6.18 -0.32 1.92e-9 Mitral valve prolapse; CRC cis rs6570726 0.935 rs386344 chr6:145855622 A/G cg23711669 chr6:146136114 FBXO30 0.69 12.21 0.56 1.57e-28 Lobe attachment (rater-scored or self-reported); CRC cis rs7216064 0.532 rs8065296 chr17:66018562 T/A cg12091567 chr17:66097778 LOC651250 0.92 13.92 0.61 5.72e-35 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CRC cis rs4363385 0.693 rs582345 chr1:153033406 G/A cg25856811 chr1:152973957 SPRR3 -0.24 -6.6 -0.34 1.62e-10 Inflammatory skin disease; CRC cis rs7772486 0.686 rs9399564 chr6:146078907 C/T cg23711669 chr6:146136114 FBXO30 -0.66 -11.07 -0.52 2.01e-24 Lobe attachment (rater-scored or self-reported); CRC cis rs6502050 0.799 rs4482345 chr17:80152919 G/A cg19223190 chr17:80058835 NA 0.39 6.26 0.33 1.21e-9 Life satisfaction; CRC cis rs6546550 0.901 rs1979214 chr2:70137498 G/C cg02498382 chr2:70120550 SNRNP27 -0.56 -9.49 -0.46 4.98e-19 Prevalent atrial fibrillation; CRC cis rs7312774 0.881 rs79048355 chr12:107311169 G/T cg16260113 chr12:107380972 MTERFD3 0.74 7.47 0.38 7.21e-13 Severe influenza A (H1N1) infection; CRC cis rs13217239 0.646 rs4403259 chr6:26997617 C/T cg05192639 chr6:26864778 GUSBL1 0.32 6.08 0.32 3.39e-9 Schizophrenia; CRC cis rs4665809 0.887 rs4665825 chr2:26333100 A/G cg04944784 chr2:26401820 FAM59B -0.6 -7.67 -0.39 2.01e-13 Gut microbiome composition (summer); CRC cis rs765787 0.530 rs4544188 chr15:45535393 C/A cg24006582 chr15:45444508 DUOX1 -0.57 -8.79 -0.44 8.5e-17 Uric acid levels; CRC cis rs4713118 0.621 rs9295756 chr6:28033396 G/T cg15786705 chr6:28176104 NA 0.72 9.27 0.46 2.5e-18 Parkinson's disease; CRC cis rs2046867 0.818 rs62249874 chr3:72911202 G/C cg25664220 chr3:72788482 NA -0.42 -6.01 -0.31 5.05e-9 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; CRC cis rs939584 1.000 rs7571967 chr2:646839 T/G cg03610516 chr2:642275 NA 0.42 5.88 0.31 9.94e-9 Body mass index; CRC cis rs6860806 0.507 rs272878 chr5:131671769 C/T cg24060327 chr5:131705240 SLC22A5 0.5 7.68 0.39 1.84e-13 Breast cancer; CRC cis rs12580194 0.593 rs61957943 chr12:55749330 A/G cg19537932 chr12:55886519 OR6C68 -0.69 -8.95 -0.44 2.63e-17 Cancer; CRC cis rs10504229 1.000 rs55787104 chr8:58178519 C/T cg24829409 chr8:58192753 C8orf71 -0.68 -11.27 -0.53 3.98e-25 Developmental language disorder (linguistic errors); CRC trans rs2303319 0.504 rs56009150 chr2:162598582 T/C cg23919916 chr10:103825097 HPS6 -0.69 -5.99 -0.31 5.59e-9 Cognitive function; CRC cis rs13191362 0.935 rs66635391 chr6:162964577 G/A cg06582575 chr6:163149167 PACRG;PARK2 0.81 10.14 0.49 3.29e-21 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs9300255 0.543 rs1260294 chr12:123560289 T/C cg00376283 chr12:123451042 ABCB9 -0.6 -6.95 -0.36 2.01e-11 Neutrophil percentage of white cells; CRC cis rs10751667 0.580 rs7395515 chr11:1005160 C/T cg23136738 chr11:925521 AP2A2 -0.4 -6.19 -0.32 1.77e-9 Alzheimer's disease (late onset); CRC cis rs1153858 1.000 rs72623915 chr15:45647433 C/T cg21132104 chr15:45694354 SPATA5L1 0.59 8.71 0.43 1.49e-16 Homoarginine levels; CRC cis rs4843747 0.671 rs9921236 chr16:88117015 G/T cg17633681 chr16:88106987 BANP 0.82 14.11 0.61 1.12e-35 Menopause (age at onset); CRC cis rs6502050 0.842 rs8080305 chr17:80074516 A/C cg22110888 chr17:80059540 CCDC57 -0.42 -6.63 -0.34 1.35e-10 Life satisfaction; CRC trans rs1814175 0.817 rs4881627 chr11:49953955 C/A cg11707556 chr5:10655725 ANKRD33B -0.42 -8.01 -0.4 2.02e-14 Height; CRC cis rs56114371 0.530 rs169262 chr6:27770890 C/T cg02683197 chr6:28174875 NA 0.52 5.98 0.31 5.91e-9 Breast cancer; CRC cis rs11191205 0.645 rs12255642 chr10:103456726 A/G cg15320455 chr10:103880129 LDB1 0.55 5.95 0.31 7.03e-9 Intelligence (multi-trait analysis); CRC cis rs2243480 1.000 rs35542501 chr7:65431215 T/C cg12463550 chr7:65579703 CRCP 0.62 5.97 0.31 6.09e-9 Diabetic kidney disease; CRC cis rs11168351 0.864 rs12228750 chr12:48496997 G/A cg00601486 chr12:48723148 H1FNT -0.34 -6.67 -0.35 1.1e-10 Bipolar disorder and schizophrenia; CRC cis rs4919694 1.000 rs77969925 chr10:104649357 C/T cg04362960 chr10:104952993 NT5C2 1.09 9.57 0.47 2.6e-19 Arsenic metabolism; CRC cis rs2075371 1.000 rs1862047 chr7:133978078 G/C cg20476274 chr7:133979776 SLC35B4 0.81 14.98 0.64 4.66e-39 Mean platelet volume; CRC cis rs6500395 1.000 rs924476 chr16:48556847 C/T cg04672837 chr16:48644449 N4BP1 0.43 6.22 0.32 1.47e-9 Response to tocilizumab in rheumatoid arthritis; CRC cis rs73206853 0.563 rs73194032 chr12:111162182 G/A cg12870014 chr12:110450643 ANKRD13A 0.75 8.94 0.44 2.88e-17 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC cis rs1707322 1.000 rs785468 chr1:46521517 G/A cg06784218 chr1:46089804 CCDC17 -0.55 -9.71 -0.47 9.27e-20 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs9457247 1.000 rs386548 chr6:167385533 A/T cg23791538 chr6:167370224 RNASET2 0.36 5.67 0.3 3.1e-8 Crohn's disease; CRC cis rs1552244 0.882 rs6443279 chr3:10053599 C/A cg18598329 chr3:10140678 FANCD2;C3orf24 -0.83 -10.72 -0.51 3.41e-23 Alzheimer's disease; CRC cis rs2576037 0.901 rs2571021 chr18:44583498 A/G cg23996704 chr18:44553084 KATNAL2 0.28 5.7 0.3 2.69e-8 Personality dimensions; CRC cis rs9323205 0.871 rs2999393 chr14:51655167 G/T cg23942311 chr14:51606299 NA 0.62 8.87 0.44 4.64e-17 Cancer; CRC cis rs561341 0.882 rs72825748 chr17:30367396 G/A cg19193384 chr17:30244184 NA -0.64 -7.42 -0.38 1.04e-12 Hip circumference adjusted for BMI; CRC cis rs6952808 0.689 rs12670737 chr7:2046830 C/T cg00106254 chr7:1943704 MAD1L1 -0.48 -7.07 -0.36 9.07e-12 Bipolar disorder and schizophrenia; CRC cis rs35110281 0.811 rs7275705 chr21:45056453 G/C cg01579765 chr21:45077557 HSF2BP -0.38 -7.45 -0.38 8.29e-13 Mean corpuscular volume; CRC cis rs11628318 0.614 rs1190337 chr14:103106159 A/C cg12046867 chr14:103022105 NA -0.78 -9.17 -0.45 5.22e-18 Platelet count; CRC cis rs891088 0.677 rs13306455 chr19:7184721 C/T cg00428638 chr19:7224713 INSR -0.56 -6.04 -0.32 4.08e-9 Hip circumference adjusted for BMI;Height; CRC cis rs4975709 0.589 rs4975746 chr5:1861069 G/A cg11168104 chr5:1857477 NA -0.38 -6.59 -0.34 1.8e-10 Cardiovascular disease risk factors; CRC cis rs6684514 1.000 rs67034206 chr1:156270260 C/T cg16558208 chr1:156270281 VHLL 0.57 8.85 0.44 5.32e-17 Mean corpuscular hemoglobin concentration;Glycated hemoglobin levels; CRC cis rs73206853 0.841 rs55754138 chr12:110869335 G/T cg12870014 chr12:110450643 ANKRD13A 0.76 8.24 0.41 4.16e-15 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC cis rs6500395 0.890 rs3843724 chr16:48618573 C/G cg04672837 chr16:48644449 N4BP1 0.42 6.04 0.32 4.1e-9 Response to tocilizumab in rheumatoid arthritis; CRC cis rs13315871 1.000 rs11715445 chr3:58343888 T/C cg20936604 chr3:58311152 NA -0.77 -7.31 -0.37 2.1e-12 Cholesterol, total; CRC trans rs8002861 0.664 rs9525873 chr13:44482204 T/C cg12856521 chr11:46389249 DGKZ 0.43 6.73 0.35 7.62e-11 Leprosy; CRC cis rs6701037 0.681 rs6664840 chr1:175128726 A/G cg00321850 chr1:175162397 KIAA0040 -0.41 -6.77 -0.35 6.02e-11 Alcohol dependence; CRC cis rs2228479 0.850 rs1800339 chr16:89839637 C/A cg06656553 chr16:89960601 TCF25 -0.7 -5.97 -0.31 6.14e-9 Skin colour saturation; CRC cis rs317689 0.819 rs317660 chr12:69686203 G/A cg20891283 chr12:69753455 YEATS4 0.46 6.05 0.32 4.03e-9 Response to diuretic therapy; CRC cis rs1552244 0.572 rs7645667 chr3:10157337 C/A cg08888203 chr3:10149979 C3orf24 0.72 8.59 0.43 3.67e-16 Alzheimer's disease; CRC cis rs711245 0.518 rs11886145 chr2:36825716 C/G cg10546459 chr2:36825355 FEZ2 0.62 8.75 0.43 1.11e-16 Height; CRC cis rs2742417 1.000 rs2673037 chr3:45749094 A/T cg04837898 chr3:45731254 SACM1L -0.36 -5.92 -0.31 8e-9 Response to anti-depressant treatment in major depressive disorder; CRC cis rs1941023 0.584 rs10750937 chr11:60172087 C/T cg08716584 chr11:60157161 MS4A7 -0.57 -9.23 -0.45 3.44e-18 Congenital heart disease (maternal effect); CRC cis rs1005277 0.579 rs1740742 chr10:38518860 C/T cg17219203 chr10:38645113 HSD17B7P2 -0.41 -5.92 -0.31 8.11e-9 Extrinsic epigenetic age acceleration; CRC cis rs752010 0.905 rs4525030 chr1:42091307 G/C cg06885757 chr1:42089581 HIVEP3 0.37 6.57 0.34 1.98e-10 Lupus nephritis in systemic lupus erythematosus; CRC cis rs28386778 0.897 rs11079510 chr17:61820902 T/C cg22520471 chr17:61851767 DDX42;CCDC47 0.73 11.44 0.53 1.01e-25 Prudent dietary pattern; CRC cis rs853679 1.000 rs7740487 chr6:28216486 C/G cg15845792 chr6:28175446 NA 0.73 6.86 0.35 3.38e-11 Depression; CRC cis rs2019137 0.539 rs6755040 chr2:113981137 T/C cg11763394 chr2:113992921 PAX8;LOC440839;LOC654433 0.66 10.25 0.49 1.45e-21 Lymphocyte counts; CRC cis rs801193 0.569 rs2707847 chr7:66202871 C/G cg18876405 chr7:65276391 NA 0.51 8.29 0.42 3.02e-15 Aortic root size; CRC cis rs35883536 0.647 rs945329 chr1:101084273 C/T cg06223162 chr1:101003688 GPR88 -0.32 -5.61 -0.3 4.29e-8 Monocyte count; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg20935933 chr6:143382018 AIG1 -0.47 -7.35 -0.38 1.59e-12 Myopia (pathological); CRC cis rs2708977 0.730 rs674920 chr2:97070156 C/G cg23100626 chr2:96804247 ASTL 0.24 6.33 0.33 7.96e-10 Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes; CRC cis rs7192380 0.639 rs2917666 chr16:69763960 C/G cg00738113 chr16:70207722 CLEC18C 0.41 7.01 0.36 1.33e-11 Sjögren's syndrome; CRC cis rs1904096 0.506 rs13434570 chr4:95168019 T/C cg11021082 chr4:95130006 SMARCAD1 -0.6 -9.51 -0.46 4.2e-19 Type 2 diabetes; CRC trans rs7824557 0.524 rs7835318 chr8:10953874 G/A cg06636001 chr8:8085503 FLJ10661 -0.66 -10.56 -0.5 1.22e-22 Retinal vascular caliber; CRC cis rs919433 0.680 rs12621129 chr2:198265350 T/C cg10820045 chr2:198174542 NA -0.44 -7.08 -0.36 9.03e-12 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC cis rs1005277 0.579 rs2472173 chr10:38374638 G/A cg00409905 chr10:38381863 ZNF37A -0.67 -11.24 -0.53 5.14e-25 Extrinsic epigenetic age acceleration; CRC cis rs2836974 0.584 rs34436313 chr21:40685246 A/G cg22974920 chr21:40686053 BRWD1 -0.45 -6.0 -0.31 5.12e-9 Cognitive function; CRC cis rs7586879 0.789 rs67221599 chr2:25131948 T/C cg22495460 chr2:25135724 ADCY3 -0.89 -15.31 -0.64 2.54e-40 Body mass index; CRC cis rs7666738 0.830 rs35752787 chr4:98935202 G/A cg05340658 chr4:99064831 C4orf37 0.6 9.35 0.46 1.41e-18 Colonoscopy-negative controls vs population controls; CRC cis rs6694672 1.000 rs1115246 chr1:197037449 A/G cg13682187 chr1:196946512 CFHR5 0.48 7.42 0.38 9.89e-13 Asthma; CRC cis rs12477438 0.748 rs10200974 chr2:99675227 A/G cg26064155 chr2:99771622 LIPT1;TSGA10 -0.63 -8.55 -0.43 4.61e-16 Chronic sinus infection; CRC cis rs2204008 0.720 rs11170774 chr12:38021722 C/T cg13010199 chr12:38710504 ALG10B -0.49 -7.25 -0.37 3.03e-12 Bladder cancer; CRC cis rs300703 0.935 rs10193882 chr2:246301 A/T cg21211680 chr2:198530 NA -0.91 -7.77 -0.39 1.02e-13 Blood protein levels; CRC cis rs9527 0.615 rs10883811 chr10:104727279 A/G cg04362960 chr10:104952993 NT5C2 0.6 8.55 0.43 4.74e-16 Arsenic metabolism; CRC trans rs11146838 1 rs11146838 chr10:39149977 A/T cg11292332 chr7:45801988 SEPT13 -0.35 -6.16 -0.32 2.15e-9 Breast cancer; CRC cis rs4629180 0.586 rs1159902 chr2:102133641 G/A cg01388757 chr2:102091195 RFX8 -0.37 -5.7 -0.3 2.62e-8 Chronic rhinosinusitis with nasal polyps; CRC cis rs4474465 0.850 rs10793327 chr11:78256841 A/C cg27205649 chr11:78285834 NARS2 0.49 6.3 0.33 9.73e-10 Alzheimer's disease (survival time); CRC cis rs4243830 0.737 rs4908909 chr1:6599041 C/T cg15205204 chr1:6545172 PLEKHG5 0.4 5.73 0.3 2.26e-8 Body mass index; CRC cis rs56104184 0.830 rs17206679 chr19:49342237 C/G cg15549821 chr19:49342101 PLEKHA4 -0.84 -9.13 -0.45 7.35e-18 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; CRC cis rs7172677 0.768 rs72730583 chr15:75351630 T/C cg14664628 chr15:75095509 CSK 0.55 6.56 0.34 2.07e-10 Systemic lupus erythematosus and Systemic sclerosis; CRC trans rs4332037 0.539 rs34571717 chr7:2106855 T/C cg11693508 chr17:37793320 STARD3 0.46 6.19 0.32 1.82e-9 Bipolar disorder; CRC cis rs6998277 0.830 rs6468838 chr8:103609336 T/C cg10187029 chr8:103597600 NA 0.94 15.24 0.64 4.91e-40 Migraine; CRC trans rs208520 0.634 rs3909071 chr6:66836947 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.08 -14.91 -0.64 9.44e-39 Exhaled nitric oxide output; CRC cis rs2032447 0.507 rs478349 chr6:25894057 T/C cg15691649 chr6:25882328 NA -0.53 -6.65 -0.34 1.2e-10 Intelligence (multi-trait analysis); CRC cis rs6502050 0.799 rs7501461 chr17:80109806 C/T cg19223190 chr17:80058835 NA 0.4 6.36 0.33 6.88e-10 Life satisfaction; CRC cis rs11098699 0.784 rs7684146 chr4:124207309 C/A cg09941581 chr4:124220074 SPATA5 0.4 5.87 0.31 1.08e-8 Mosquito bite size; CRC cis rs9733 0.519 rs6700022 chr1:150670484 G/T cg15448220 chr1:150897856 SETDB1 -0.47 -6.92 -0.36 2.44e-11 Tonsillectomy; CRC cis rs7927771 1.000 rs10838738 chr11:47663049 A/G cg20307385 chr11:47447363 PSMC3 -0.56 -7.77 -0.39 1e-13 Subjective well-being; CRC cis rs11122272 0.735 rs2739518 chr1:231537633 C/T cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.59 -8.81 -0.44 7.15e-17 Hemoglobin concentration; CRC cis rs9894429 1.000 rs4074915 chr17:79579230 G/A cg18240062 chr17:79603768 NPLOC4 -0.56 -9.34 -0.46 1.54e-18 Eye color traits; CRC cis rs1799949 1.000 rs4793191 chr17:41204377 A/G cg19454999 chr17:41278357 BRCA1;NBR2 0.54 8.53 0.43 5.37e-16 Menopause (age at onset); CRC cis rs826838 0.967 rs1719853 chr12:39128515 A/G cg26384229 chr12:38710491 ALG10B -0.64 -9.71 -0.47 9.26e-20 Heart rate; CRC cis rs8017423 0.647 rs12883357 chr14:90815032 A/G cg14092571 chr14:90743983 NA 0.4 6.23 0.32 1.4e-9 Mortality in heart failure; CRC cis rs9311474 0.713 rs352168 chr3:52237970 C/T cg08222913 chr3:52553049 STAB1 -0.35 -6.51 -0.34 2.88e-10 Electroencephalogram traits; CRC trans rs1997103 1.000 rs4947503 chr7:55409427 G/T cg20935933 chr6:143382018 AIG1 0.5 6.46 0.34 3.68e-10 QRS interval (sulfonylurea treatment interaction); CRC cis rs72781680 0.611 rs72783636 chr2:24328706 C/T cg20701182 chr2:24300061 SF3B14 0.61 7.18 0.37 4.75e-12 Lymphocyte counts; CRC trans rs11039798 0.557 rs683180 chr11:48463949 A/G cg03929089 chr4:120376271 NA -0.63 -6.78 -0.35 5.65e-11 Axial length; CRC cis rs311392 0.554 rs2666884 chr8:55100906 T/C cg06042504 chr8:55087323 NA -0.38 -5.9 -0.31 9.06e-9 Pelvic organ prolapse (moderate/severe); CRC cis rs3785574 0.962 rs8066463 chr17:61818390 A/G cg23090583 chr17:61904693 PSMC5;FTSJ3 0.64 9.41 0.46 8.84e-19 Height; CRC cis rs9443189 0.570 rs9341532 chr6:76403674 A/G cg01950844 chr6:76311363 SENP6 0.74 9.84 0.48 3.35e-20 Prostate cancer; CRC cis rs6500395 0.962 rs9937134 chr16:48577683 T/A cg04672837 chr16:48644449 N4BP1 0.42 6.06 0.32 3.73e-9 Response to tocilizumab in rheumatoid arthritis; CRC cis rs7618915 0.547 rs6762813 chr3:52726695 C/T cg11645453 chr3:52864694 ITIH4 0.36 6.34 0.33 7.78e-10 Bipolar disorder; CRC cis rs116095464 0.614 rs10067482 chr5:219328 T/G cg22857025 chr5:266934 NA -1.23 -16.9 -0.68 1.4300000000000001e-46 Breast cancer; CRC cis rs62432291 0.681 rs1699442 chr6:159655918 A/C cg14500486 chr6:159655392 FNDC1 0.74 9.9 0.48 2.08e-20 Joint mobility (Beighton score); CRC cis rs11122272 0.735 rs2250719 chr1:231486208 G/A cg06096015 chr1:231504339 EGLN1 0.39 5.9 0.31 8.9e-9 Hemoglobin concentration; CRC cis rs2204008 0.774 rs8186954 chr12:38318566 C/A cg13010199 chr12:38710504 ALG10B 0.46 6.3 0.33 9.4e-10 Bladder cancer; CRC cis rs9560113 0.959 rs9555802 chr13:112179504 T/C cg10483660 chr13:112241077 NA 0.36 5.81 0.3 1.49e-8 Menarche (age at onset); CRC trans rs1005277 0.579 rs2505240 chr10:38442419 G/T cg23533926 chr12:111358616 MYL2 -0.52 -7.87 -0.4 5.24e-14 Extrinsic epigenetic age acceleration; CRC cis rs3106136 0.527 rs2664894 chr4:95153831 T/C cg11021082 chr4:95130006 SMARCAD1 -0.6 -9.52 -0.46 4e-19 Capecitabine sensitivity; CRC cis rs2549003 1.000 rs2549007 chr5:131826875 T/C cg21138405 chr5:131827807 IRF1 -0.58 -11.3 -0.53 3.09e-25 Asthma (sex interaction); CRC cis rs1448094 0.621 rs10863090 chr12:86282211 C/T cg18827107 chr12:86230957 RASSF9 -0.45 -7.24 -0.37 3.29e-12 Major depressive disorder; CRC cis rs7119 0.717 rs7181283 chr15:77814544 G/A cg10437265 chr15:77819839 NA 0.7 12.76 0.58 1.43e-30 Type 2 diabetes; CRC cis rs1218582 0.772 rs906593 chr1:154885255 G/A cg09359103 chr1:154839909 KCNN3 -0.71 -12.5 -0.57 1.32e-29 Prostate cancer; CRC cis rs853679 0.517 rs9380065 chr6:28144751 A/G cg03623178 chr6:28175578 NA 0.97 12.38 0.56 3.55e-29 Depression; CRC cis rs875971 0.545 rs73142245 chr7:65691649 A/G cg11764359 chr7:65958608 NA 0.45 5.67 0.3 3.1e-8 Aortic root size; CRC cis rs10197940 0.662 rs4592848 chr2:152337822 G/A cg06191203 chr2:152266755 RIF1 -0.72 -10.45 -0.5 2.92e-22 Lung cancer; CRC cis rs8180040 0.620 rs6414435 chr3:47121140 A/G cg10298567 chr3:47292165 KIF9 -0.39 -5.99 -0.31 5.52e-9 Colorectal cancer; CRC cis rs908922 0.676 rs4240883 chr1:152526260 C/T cg23254163 chr1:152506842 NA 0.49 9.71 0.47 9.49e-20 Hair morphology; CRC cis rs4713118 0.662 rs464312 chr6:27967591 T/A cg20615401 chr6:28092323 ZSCAN16 0.44 5.77 0.3 1.82e-8 Parkinson's disease; CRC cis rs17253792 0.822 rs113649689 chr14:56088065 G/A cg24579896 chr14:56047964 C14orf33;KTN1 0.71 5.69 0.3 2.81e-8 Putamen volume; CRC cis rs7927771 1.000 rs4752857 chr11:47655752 C/T cg18512352 chr11:47633146 NA -0.48 -9.56 -0.47 2.79e-19 Subjective well-being; CRC cis rs11190604 1.000 rs2489053 chr10:102353341 A/G cg07080220 chr10:102295463 HIF1AN 0.51 6.41 0.33 4.94e-10 Palmitoleic acid (16:1n-7) levels; CRC cis rs939584 1.000 rs35142762 chr2:636790 T/C cg03610516 chr2:642275 NA -0.42 -5.66 -0.3 3.3e-8 Body mass index; CRC cis rs514406 0.698 rs567880 chr1:53348564 T/G cg25767906 chr1:53392781 SCP2 -0.5 -7.84 -0.4 6.21e-14 Monocyte count; CRC cis rs9611519 0.929 rs4820423 chr22:41430338 A/T cg03806693 chr22:41940476 POLR3H -0.54 -6.89 -0.36 2.86e-11 Neuroticism; CRC trans rs7474896 0.778 rs35215319 chr10:37908999 G/T cg16724811 chr16:15130678 PDXDC1 -0.62 -6.12 -0.32 2.72e-9 Obesity (extreme); CRC cis rs875971 0.564 rs313804 chr7:65514622 A/G cg18876405 chr7:65276391 NA 0.51 8.73 0.43 1.35e-16 Aortic root size; CRC cis rs12403795 1.000 rs12403795 chr1:150278389 A/G cg17724175 chr1:150552817 MCL1 -0.6 -6.99 -0.36 1.54e-11 Illicit drug use; CRC cis rs2839186 0.632 rs2839184 chr21:47689013 G/A cg00815214 chr21:47717953 NA -0.4 -6.6 -0.34 1.69e-10 Testicular germ cell tumor; CRC cis rs1008375 0.932 rs13134570 chr4:17692863 C/T cg16339924 chr4:17578868 LAP3 -0.46 -5.82 -0.31 1.39e-8 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs4713118 0.629 rs203889 chr6:28021775 T/G cg15845792 chr6:28175446 NA 0.94 13.84 0.61 1.17e-34 Parkinson's disease; CRC cis rs4713118 0.513 rs149959 chr6:28013854 T/C cg06470822 chr6:28175283 NA 0.8 11.94 0.55 1.51e-27 Parkinson's disease; CRC cis rs939658 0.805 rs35230534 chr15:79441093 T/C cg17916960 chr15:79447300 NA -0.44 -7.1 -0.36 7.67e-12 Refractive error; CRC cis rs11098499 0.863 rs1480939 chr4:120456927 T/C cg09307838 chr4:120376055 NA 0.69 10.41 0.5 3.93e-22 Corneal astigmatism; CRC cis rs916888 0.821 rs199513 chr17:44856932 A/G cg17911788 chr17:44343683 NA 0.55 7.04 0.36 1.1e-11 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs7659604 0.540 rs11098643 chr4:122701507 C/A cg19748678 chr4:122722346 EXOSC9 -0.43 -5.81 -0.31 1.44e-8 Type 2 diabetes; CRC cis rs6951245 0.554 rs10246354 chr7:1132456 C/T cg24642844 chr7:1081250 C7orf50 -0.51 -6.56 -0.34 2.03e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs801193 1.000 rs4717319 chr7:66242593 A/G cg25985355 chr7:65971099 NA -0.32 -5.66 -0.3 3.38e-8 Aortic root size; CRC cis rs6754459 0.502 rs34759180 chr2:3707394 C/T cg10645314 chr2:3704589 ALLC -1.06 -11.92 -0.55 1.86e-27 Response to inhaled corticosteroid treatment in asthma (change in FEV1); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg13795627 chr1:157015873 ARHGEF11 0.41 7.1 0.36 7.58e-12 Liver disease severity in Alagille syndrome; CRC cis rs7659604 0.539 rs2063165 chr4:122750005 A/G cg06713675 chr4:122721982 EXOSC9 -0.51 -8.28 -0.42 3.21e-15 Type 2 diabetes; CRC cis rs5758511 0.773 rs8140869 chr22:42344297 A/G cg00645731 chr22:42541494 CYP2D7P1 -0.48 -7.56 -0.38 4.18e-13 Birth weight; CRC cis rs11997175 0.583 rs66622174 chr8:33812542 T/G cg04338863 chr8:33670619 NA 0.44 6.49 0.34 3.15e-10 Body mass index; CRC trans rs12517041 1.000 rs58571178 chr5:23294196 A/G ch.8.1293020R chr8:59333349 UBXN2B -0.55 -6.17 -0.32 2.05e-9 Calcium levels; CRC cis rs11679072 0.850 rs11679075 chr2:240444254 C/T cg03276489 chr2:240449683 NA -0.93 -7.0 -0.36 1.45e-11 Blood pressure (smoking interaction); CRC cis rs1048238 0.506 rs7552077 chr1:16196759 A/G cg21385522 chr1:16154831 NA 0.6 9.05 0.45 1.3e-17 Systolic blood pressure; CRC trans rs1814175 0.616 rs4881723 chr11:49788566 G/T cg03929089 chr4:120376271 NA -0.92 -16.17 -0.67 1.04e-43 Height; CRC trans rs660498 0.785 rs2478251 chr10:27739063 A/T cg13661793 chr10:32399026 NA 0.33 5.99 0.31 5.37e-9 Asthma (childhood onset); CRC cis rs6674176 0.597 rs12127737 chr1:44402565 G/A cg12908607 chr1:44402522 ARTN -0.64 -12.01 -0.55 8.56e-28 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Cognitive ability; CRC cis rs10416265 0.527 rs7508599 chr19:33546512 A/T cg27124370 chr19:33622961 WDR88 0.48 7.09 0.36 8.37e-12 Bone properties (heel); CRC trans rs2303319 0.504 rs12474470 chr2:162535336 T/C cg18122310 chr12:50236657 BCDIN3D -0.73 -6.13 -0.32 2.58e-9 Cognitive function; CRC cis rs4713118 0.662 rs149901 chr6:27965503 C/T cg10876282 chr6:28092338 ZSCAN16 0.44 5.88 0.31 9.85e-9 Parkinson's disease; CRC cis rs9907295 0.818 rs4795089 chr17:34119397 C/T cg14527050 chr17:34077244 GAS2L2 0.61 5.68 0.3 2.91e-8 Fibroblast growth factor basic levels; CRC cis rs4664293 0.867 rs34392518 chr2:160605878 G/T cg08347373 chr2:160653686 CD302 -0.46 -7.39 -0.38 1.24e-12 Monocyte percentage of white cells; CRC cis rs4713118 0.568 rs9468213 chr6:27706180 G/A cg03623178 chr6:28175578 NA 0.57 8.06 0.41 1.43e-14 Parkinson's disease; CRC cis rs2386661 0.547 rs72781996 chr10:5646485 C/G cg26603656 chr10:5671107 NA 0.42 6.81 0.35 4.58e-11 Breast cancer; CRC cis rs1448094 0.791 rs11117122 chr12:86337749 A/C cg18827107 chr12:86230957 RASSF9 -0.43 -6.83 -0.35 4.16e-11 Major depressive disorder; CRC cis rs282587 0.569 rs166865 chr13:113384879 A/G cg04656015 chr13:113407548 ATP11A 0.58 7.39 0.38 1.2e-12 Glycated hemoglobin levels; CRC cis rs1536827 0.620 rs10857735 chr10:135336230 A/C cg16964102 chr10:135390573 NA -0.46 -5.75 -0.3 2.05e-8 Visceral adipose tissue/subcutaneous adipose tissue ratio; CRC cis rs13108904 0.901 rs12509700 chr4:1296321 A/G cg16405210 chr4:1374714 KIAA1530 -0.42 -6.1 -0.32 3.06e-9 Obesity-related traits; CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg04238871 chr10:126431886 FAM53B -0.52 -6.3 -0.33 9.29e-10 Diisocyanate-induced asthma; CRC cis rs116095464 0.558 rs10055354 chr5:243794 G/A cg22496380 chr5:211416 CCDC127 -0.91 -10.41 -0.5 4.13e-22 Breast cancer; CRC trans rs9858542 0.953 rs71324979 chr3:49619651 T/C cg21659725 chr3:3221576 CRBN -0.71 -9.59 -0.47 2.22e-19 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs7607369 0.648 rs7599984 chr2:219656713 T/G cg02176678 chr2:219576539 TTLL4 -0.56 -8.96 -0.44 2.44e-17 Red blood cell count;Amyotrophic lateral sclerosis; CRC cis rs13191362 1.000 rs55822577 chr6:163069710 G/A cg23758597 chr6:163146217 PARK2 -0.65 -6.58 -0.34 1.91e-10 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs9811920 0.609 rs793466 chr3:99609837 C/T cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G 0.46 6.18 0.32 1.87e-9 Axial length; CRC cis rs13118159 0.742 rs7679860 chr4:1333987 C/T cg15763984 chr4:1342303 KIAA1530 0.48 8.05 0.41 1.52e-14 Longevity; CRC cis rs2832191 0.646 rs2832214 chr21:30517127 C/T cg24692254 chr21:30365293 RNF160 -0.58 -8.49 -0.42 7e-16 Dental caries; CRC cis rs17270561 0.609 rs9467572 chr6:25704126 T/G cg16482183 chr6:26056742 HIST1H1C -0.72 -9.15 -0.45 6.11e-18 Iron status biomarkers; CRC cis rs9649213 0.574 rs12873 chr7:97922773 T/C cg00277769 chr7:97922759 BAIAP2L1 -0.62 -11.07 -0.52 2.07e-24 Prostate cancer (SNP x SNP interaction); CRC trans rs7615952 0.599 rs6438955 chr3:125730333 C/A cg07211511 chr3:129823064 LOC729375 -0.8 -12.36 -0.56 4.26e-29 Blood pressure (smoking interaction); CRC cis rs8060686 0.641 rs16957696 chr16:68039850 C/T cg08314208 chr16:67682810 RLTPR -0.65 -6.8 -0.35 4.91e-11 HDL cholesterol;Metabolic syndrome; CRC cis rs9938149 0.706 rs7498700 chr16:88320620 T/C cg05435882 chr16:88311214 NA -0.47 -6.26 -0.33 1.23e-9 Corneal structure;Central corneal thickness; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg10128753 chr12:53693453 C12orf10 0.57 8.1 0.41 1.09e-14 Response to antipsychotic treatment; CRC cis rs11971779 0.553 rs10228643 chr7:139115420 G/A cg23387468 chr7:139079360 LUC7L2 0.41 7.04 0.36 1.14e-11 Diisocyanate-induced asthma; CRC cis rs593982 1.000 rs593982 chr11:65513107 T/C cg08755490 chr11:65554678 OVOL1 1.23 18.84 0.72 3.1e-54 Atopic dermatitis; CRC cis rs801193 0.569 rs13242290 chr7:66121885 G/A cg00343986 chr7:65444356 GUSB -0.45 -6.15 -0.32 2.25e-9 Aortic root size; CRC cis rs2404602 0.692 rs2304920 chr15:76993867 T/C cg03037974 chr15:76606532 NA 0.69 12.13 0.56 3.19e-28 Blood metabolite levels; CRC cis rs7223966 1.000 rs7223412 chr17:61808172 T/C cg23090583 chr17:61904693 PSMC5;FTSJ3 0.5 6.18 0.32 1.89e-9 Hip circumference adjusted for BMI;Body mass index; CRC cis rs7301826 0.610 rs4759791 chr12:131296495 A/G cg11011512 chr12:131303247 STX2 0.37 5.62 0.3 4.1e-8 Plasma plasminogen activator levels; CRC trans rs208520 0.526 rs2881644 chr6:66803535 A/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 1.16 24.84 0.81 1.83e-77 Exhaled nitric oxide output; CRC cis rs6424115 1.000 rs4237 chr1:24114129 C/T cg10978503 chr1:24200527 CNR2 0.47 8.35 0.42 1.86e-15 Immature fraction of reticulocytes; CRC cis rs7772486 0.720 rs1890171 chr6:146072114 T/C cg05347473 chr6:146136440 FBXO30 -0.39 -5.84 -0.31 1.26e-8 Lobe attachment (rater-scored or self-reported); CRC cis rs4843747 0.636 rs4075597 chr16:88107590 C/A cg03395651 chr16:88107091 BANP 0.6 7.9 0.4 4.18e-14 Menopause (age at onset); CRC cis rs853679 0.517 rs9348797 chr6:28137533 G/C cg18032046 chr6:28092343 ZSCAN16 -0.51 -5.93 -0.31 7.47e-9 Depression; CRC cis rs8067545 0.750 rs4924803 chr17:19991806 C/T cg13482628 chr17:19912719 NA 0.48 7.7 0.39 1.56e-13 Schizophrenia; CRC cis rs394563 0.591 rs6570963 chr6:149691355 T/G cg07828024 chr6:149772892 ZC3H12D 0.47 8.73 0.43 1.3e-16 Dupuytren's disease; CRC cis rs12541635 0.934 rs62527400 chr8:107054229 G/A cg10147462 chr8:107024639 NA 0.46 7.63 0.39 2.48e-13 Age of smoking initiation; CRC cis rs10256972 0.630 rs13235747 chr7:1129123 T/C cg03188948 chr7:1209495 NA 0.44 6.22 0.32 1.5e-9 Longevity;Endometriosis; CRC cis rs763121 0.853 rs10135 chr22:39082174 C/T cg06022373 chr22:39101656 GTPBP1 -0.82 -13.98 -0.61 3.61e-35 Menopause (age at onset); CRC trans rs3008706 0.539 rs9407665 chr9:15854139 T/C cg15918921 chr2:74212782 NA -0.52 -6.08 -0.32 3.28e-9 Bilirubin levels; CRC cis rs7412746 0.621 rs11204749 chr1:150929563 G/A cg17724175 chr1:150552817 MCL1 0.41 6.3 0.33 9.34e-10 Melanoma; CRC cis rs2836754 1.000 rs2836753 chr21:40291187 A/G cg16734191 chr21:40194848 ETS2 -0.31 -5.66 -0.3 3.23e-8 Crohn's disease;Body mass index; CRC cis rs7301826 0.651 rs10734979 chr12:131288954 T/C cg11011512 chr12:131303247 STX2 0.37 5.6 0.3 4.44e-8 Plasma plasminogen activator levels; CRC cis rs9911578 0.967 rs6503883 chr17:56917543 C/T cg05425664 chr17:57184151 TRIM37 -0.49 -7.72 -0.39 1.45e-13 Intelligence (multi-trait analysis); CRC cis rs7772486 0.686 rs9386131 chr6:146121608 G/A cg13319975 chr6:146136371 FBXO30 -0.42 -6.32 -0.33 8.58e-10 Lobe attachment (rater-scored or self-reported); CRC trans rs1346081 0.786 rs1425645 chr4:68028175 C/T cg24579212 chr6:112408909 TUBE1;C6orf225 0.5 5.98 0.31 5.76e-9 Intelligence (multi-trait analysis); CRC cis rs600806 0.850 rs4970729 chr1:109979202 G/A cg23032129 chr1:109941072 SORT1 -0.28 -5.99 -0.31 5.62e-9 Intelligence (multi-trait analysis); CRC cis rs2839186 0.588 rs2839140 chr21:47616080 G/A cg13012494 chr21:47604986 C21orf56 -0.48 -7.8 -0.39 8.46e-14 Testicular germ cell tumor; CRC cis rs7772486 0.764 rs9399569 chr6:146242942 C/T cg23711669 chr6:146136114 FBXO30 -0.66 -11.26 -0.53 4.41e-25 Lobe attachment (rater-scored or self-reported); CRC trans rs1506636 1.000 rs2299984 chr7:123356921 G/T cg04128746 chr10:128995134 FAM196A;DOCK1 -0.36 -6.05 -0.32 3.98e-9 Plateletcrit;Platelet count; CRC cis rs12497850 0.543 rs6446218 chr3:49075513 A/T cg20833759 chr3:49053208 WDR6;DALRD3 0.54 9.2 0.45 4.22e-18 Parkinson's disease; CRC cis rs896854 0.654 rs4735337 chr8:95973465 T/C cg16049864 chr8:95962084 TP53INP1 -0.65 -11.8 -0.55 5.04e-27 Type 2 diabetes; CRC cis rs9910055 0.530 rs2269906 chr17:42294337 G/T cg10896456 chr17:42255109 ASB16;C17orf65 -0.34 -5.96 -0.31 6.47e-9 Total body bone mineral density; CRC cis rs1552244 1.000 rs1552244 chr3:10135577 A/G cg02579736 chr3:10068473 FANCD2;CIDECP 0.94 12.61 0.57 5.15e-30 Alzheimer's disease; CRC cis rs10504229 1.000 rs76023408 chr8:58193345 A/G cg22535103 chr8:58192502 C8orf71 -0.81 -12.03 -0.55 7.32e-28 Developmental language disorder (linguistic errors); CRC cis rs4731207 0.596 rs28817916 chr7:124588550 G/A cg23710748 chr7:124431027 NA -0.38 -6.08 -0.32 3.35e-9 Cutaneous malignant melanoma; CRC cis rs17666538 0.585 rs1703927 chr8:613620 A/G cg00450029 chr8:599525 NA -0.61 -5.87 -0.31 1.05e-8 IgG glycosylation; CRC cis rs926938 0.505 rs2878573 chr1:115521602 A/G cg12756093 chr1:115239321 AMPD1 0.47 6.84 0.35 3.86e-11 Autism; CRC cis rs58688157 0.705 rs12421646 chr11:578844 C/G cg01842473 chr11:617407 IRF7;MUPCDH -0.56 -6.6 -0.34 1.63e-10 Systemic lupus erythematosus; CRC cis rs1472360 0.505 rs2645049 chr8:86272555 A/G cg21346043 chr8:86351067 CA3 -0.37 -6.82 -0.35 4.43e-11 Mean corpuscular hemoglobin concentration; CRC cis rs149866169 1 rs149866169 chr6:27441723 T/A cg15845792 chr6:28175446 NA 0.77 6.1 0.32 3.04e-9 Neuroticism (multi-trait analysis);Lung cancer in ever smokers;Subjective well-being (multi-trait analysis);Lung cancer;Squamous cell lung carcinoma; CRC trans rs1814175 0.511 rs61905634 chr11:49819736 G/A cg11707556 chr5:10655725 ANKRD33B -0.42 -7.91 -0.4 4.04e-14 Height; CRC cis rs10782582 0.609 rs1628063 chr1:76391646 A/G cg10523679 chr1:76189770 ACADM -0.39 -5.62 -0.3 4.18e-8 Daytime sleep phenotypes; CRC cis rs4969178 0.600 rs2376583 chr17:76402105 A/T cg02319466 chr17:76381040 PGS1 0.37 5.87 0.31 1.07e-8 HDL cholesterol levels; CRC trans rs11581859 0.950 rs7524256 chr1:99358761 T/C cg12183875 chr3:169587454 LRRC31 0.26 6.07 0.32 3.54e-9 Response to cognitive-behavioural therapy in anxiety disorder; CRC cis rs5753618 0.561 rs2283881 chr22:31638932 G/A cg22777020 chr22:31556080 RNF185 -0.51 -5.94 -0.31 7.35e-9 Colorectal cancer; CRC cis rs950169 1.000 rs11638297 chr15:84782417 A/C cg24253500 chr15:84953950 NA 0.34 5.71 0.3 2.47e-8 Schizophrenia; CRC cis rs2762353 0.574 rs16890999 chr6:25755583 A/G cg03264133 chr6:25882463 NA 0.72 10.08 0.49 5.16e-21 Blood metabolite levels; CRC cis rs9916302 0.706 rs9899069 chr17:37540772 A/G cg00129232 chr17:37814104 STARD3 0.57 7.04 0.36 1.14e-11 Glomerular filtration rate (creatinine); CRC cis rs6495122 0.501 rs12101482 chr15:75344784 A/T cg09165964 chr15:75287851 SCAMP5 -0.51 -7.84 -0.4 6.18e-14 Caffeine consumption;Diastolic blood pressure;Coffee consumption; CRC cis rs3760982 0.813 rs8104447 chr19:44293278 T/C cg12072164 chr19:44306565 LYPD5 -0.45 -7.09 -0.36 8.4e-12 Breast cancer (estrogen-receptor negative);Breast cancer; CRC cis rs9326248 0.798 rs10892079 chr11:117016824 T/G cg15534755 chr11:117069859 TAGLN 0.33 6.01 0.31 4.91e-9 Blood protein levels; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg17910969 chr17:73521755 LLGL2 0.46 6.05 0.32 3.92e-9 Anxiety disorder; CRC cis rs1729951 0.575 rs361239 chr3:136701295 G/T cg21827317 chr3:136751795 NA 0.35 5.8 0.3 1.58e-8 Neuroticism; CRC cis rs728616 0.717 rs12415523 chr10:81691976 T/C cg11900509 chr10:81946545 ANXA11 -0.65 -6.71 -0.35 8.77e-11 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs10504229 1.000 rs3814486 chr8:58191226 A/T cg02725872 chr8:58115012 NA -0.38 -6.43 -0.33 4.44e-10 Developmental language disorder (linguistic errors); CRC cis rs9916302 0.706 rs12947506 chr17:37707592 A/G cg07936489 chr17:37558343 FBXL20 -0.92 -11.95 -0.55 1.39e-27 Glomerular filtration rate (creatinine); CRC trans rs6539288 0.803 rs10778517 chr12:107341664 G/T cg22039215 chr3:195716632 SDHAP1 -0.44 -6.08 -0.32 3.39e-9 Total body bone mineral density; CRC trans rs11098499 0.588 rs6534149 chr4:120559292 T/G cg25214090 chr10:38739885 LOC399744 -0.51 -8.1 -0.41 1.05e-14 Corneal astigmatism; CRC cis rs7312933 1.000 rs12372623 chr12:42531666 G/A cg11827402 chr12:42719852 PPHLN1;ZCRB1 0.57 7.39 0.38 1.2e-12 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CRC cis rs9486719 1.000 rs67996804 chr6:96884387 C/T cg06623918 chr6:96969491 KIAA0776 -0.81 -9.51 -0.46 4.17e-19 Migraine;Coronary artery disease; CRC cis rs294883 0.821 rs10945598 chr6:159701456 A/G cg14500486 chr6:159655392 FNDC1 -0.35 -5.75 -0.3 2.09e-8 Coronary artery disease; CRC cis rs8103278 1.000 rs7256192 chr19:46338492 G/A cg11657440 chr19:46296263 DMWD -0.5 -6.95 -0.36 1.94e-11 Coronary artery disease; CRC cis rs3106136 0.967 rs13135934 chr4:95207688 G/C cg11021082 chr4:95130006 SMARCAD1 -0.46 -7.18 -0.37 4.67e-12 Capecitabine sensitivity; CRC cis rs600626 0.529 rs58411334 chr11:75467350 G/T cg24262691 chr11:75473276 NA 0.49 6.17 0.32 2.03e-9 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CRC cis rs11650494 0.516 rs2233660 chr17:47492366 C/T cg08112188 chr17:47440006 ZNF652 -0.82 -7.59 -0.39 3.27e-13 Prostate cancer; CRC cis rs7959452 0.590 rs56054057 chr12:69775972 C/T cg20891283 chr12:69753455 YEATS4 0.91 17.35 0.69 2.48e-48 Blood protein levels; CRC cis rs501120 0.543 rs800331 chr10:44806378 C/T cg09554077 chr10:44749378 NA 0.46 6.2 0.32 1.65e-9 Coronary artery disease;Coronary heart disease; CRC cis rs1862618 0.671 rs2591956 chr5:56244604 G/A cg18230493 chr5:56204884 C5orf35 0.6 8.87 0.44 4.71e-17 Initial pursuit acceleration; CRC cis rs807029 0.533 rs735137 chr10:102735835 C/G cg04662943 chr10:102668895 NA 0.64 7.64 0.39 2.41e-13 Ejection fraction in Tripanosoma cruzi seropositivity; CRC cis rs12936587 0.535 rs6502615 chr17:17612023 C/T cg24612305 chr17:17875800 TOM1L2;LRRC48 -0.4 -5.94 -0.31 7.06e-9 Hip circumference;Coronary artery disease or large artery stroke;Coronary heart disease;Coronary artery disease; CRC cis rs853679 0.517 rs9468297 chr6:28118874 G/T cg25164649 chr6:28176230 NA 0.78 9.66 0.47 1.33e-19 Depression; CRC cis rs13256369 1.000 rs4840352 chr8:8573508 A/G cg06636001 chr8:8085503 FLJ10661 0.48 6.01 0.31 4.9e-9 Obesity-related traits; CRC cis rs4494114 1.000 rs3790441 chr1:39352492 G/A cg25970120 chr1:39325951 RRAGC -0.42 -5.74 -0.3 2.18e-8 Blood protein levels; CRC cis rs67478160 0.643 rs11847468 chr14:104220295 G/A cg01849466 chr14:104193079 ZFYVE21 -0.49 -8.76 -0.43 1.06e-16 Schizophrenia; CRC cis rs2629540 0.847 rs12247543 chr10:126419743 G/C cg08799069 chr10:126477246 METTL10 0.61 7.99 0.4 2.28e-14 Cocaine dependence; CRC cis rs400736 0.602 rs11121090 chr1:8168634 A/G cg25007680 chr1:8021821 PARK7 0.51 7.11 0.37 7.16e-12 Response to antidepressants and depression; CRC cis rs561341 1.000 rs554078 chr17:30330109 A/C cg19193384 chr17:30244184 NA -0.66 -7.6 -0.39 3.13e-13 Hip circumference adjusted for BMI; CRC cis rs9796 0.870 rs28581803 chr15:41326513 G/A cg18705301 chr15:41695430 NDUFAF1 -0.36 -6.03 -0.32 4.34e-9 Menopause (age at onset); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg06464432 chr16:71917996 ZNF821;ATXN1L 0.45 6.21 0.32 1.61e-9 Response to antipsychotic treatment; CRC cis rs1552244 1.000 rs17032414 chr3:10158302 C/G cg02579736 chr3:10068473 FANCD2;CIDECP 0.93 12.8 0.58 1.03e-30 Alzheimer's disease; CRC cis rs1218582 0.741 rs6656494 chr1:154839799 A/G cg16680214 chr1:154839983 KCNN3 -0.47 -9.44 -0.46 6.97e-19 Prostate cancer; CRC cis rs13108904 0.870 rs1960426 chr4:1274365 C/T cg19318889 chr4:1322082 MAEA 0.4 6.0 0.31 5.31e-9 Obesity-related traits; CRC cis rs10504229 1.000 rs58371676 chr8:58189382 G/A cg22535103 chr8:58192502 C8orf71 -0.82 -12.27 -0.56 9.63e-29 Developmental language disorder (linguistic errors); CRC cis rs1322512 1.000 rs2758779 chr6:153008022 T/A cg03415253 chr6:152958462 SYNE1 0.4 6.04 0.32 4.14e-9 Tonometry; CRC cis rs2455601 0.882 rs11042116 chr11:8928472 G/C cg21881798 chr11:8931708 C11orf17;ST5 -0.54 -6.08 -0.32 3.3e-9 Schizophrenia; CRC cis rs748404 0.578 rs4547312 chr15:43632138 A/G cg15269541 chr15:43626905 ADAL -0.36 -5.69 -0.3 2.74e-8 Lung cancer; CRC cis rs9323205 0.677 rs12586581 chr14:51722938 G/A cg23942311 chr14:51606299 NA -0.52 -6.13 -0.32 2.52e-9 Cancer; CRC cis rs12594515 1.000 rs6493175 chr15:45989898 T/C cg22117107 chr15:45993392 NA -0.44 -9.09 -0.45 9.56e-18 Waist circumference;Weight; CRC cis rs6582630 0.599 rs12309369 chr12:38419683 C/G cg13010199 chr12:38710504 ALG10B -0.4 -5.68 -0.3 3.02e-8 Drug-induced liver injury (flucloxacillin); CRC cis rs863345 0.564 rs10908662 chr1:158489200 C/A cg12129480 chr1:158549410 OR10X1 -0.3 -6.27 -0.33 1.13e-9 Pneumococcal bacteremia; CRC cis rs10992471 0.603 rs987553 chr9:95298694 G/T cg14631576 chr9:95140430 CENPP -0.39 -6.77 -0.35 6.01e-11 Visceral adipose tissue/subcutaneous adipose tissue ratio; CRC cis rs769267 0.929 rs2905424 chr19:19473445 T/C cg03709012 chr19:19516395 GATAD2A -0.73 -11.11 -0.52 1.5e-24 Tonsillectomy; CRC cis rs6502050 0.835 rs9911379 chr17:80114529 A/G cg19223190 chr17:80058835 NA 0.39 6.27 0.33 1.12e-9 Life satisfaction; CRC cis rs2404602 0.735 rs2454450 chr15:76831236 G/A cg23625390 chr15:77176239 SCAPER -0.83 -13.15 -0.59 4.88e-32 Blood metabolite levels; CRC cis rs3204270 0.714 rs7503307 chr17:79674929 C/G cg18367735 chr17:79674897 NA 0.49 5.74 0.3 2.21e-8 Dental caries; CRC cis rs13108904 0.875 rs73069950 chr4:1276045 C/A cg21620606 chr4:1342894 KIAA1530 -0.34 -5.91 -0.31 8.59e-9 Obesity-related traits; CRC cis rs9322193 0.923 rs62441303 chr6:150088683 A/G cg13206674 chr6:150067644 NUP43 0.57 8.19 0.41 5.85e-15 Lung cancer; CRC cis rs9467711 0.559 rs3799383 chr6:26510748 C/T cg16898833 chr6:26189333 HIST1H4D 0.8 7.01 0.36 1.33e-11 Autism spectrum disorder or schizophrenia; CRC cis rs12230513 0.732 rs61957764 chr12:55867916 G/A cg19537932 chr12:55886519 OR6C68 -0.71 -8.93 -0.44 3.12e-17 Contrast sensitivity; CRC cis rs4478858 0.698 rs6655946 chr1:31805728 G/A cg00250761 chr1:31883323 NA -0.39 -7.26 -0.37 2.78e-12 Alcohol dependence; CRC cis rs2758596 1.000 rs2842866 chr1:156159721 G/A cg25208724 chr1:156163844 SLC25A44 0.74 7.01 0.36 1.34e-11 Paclitaxel disposition in epithelial ovarian cancer; CRC cis rs61774743 0.754 rs11581271 chr1:41835061 C/G cg00290994 chr1:41848739 NA 0.46 6.95 0.36 1.93e-11 Intelligence (multi-trait analysis); CRC cis rs2739330 0.753 rs4822452 chr22:24254363 C/T cg11905131 chr22:24372483 LOC391322 -0.71 -11.49 -0.54 6.21e-26 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs2952156 0.920 rs2517955 chr17:37843681 C/T cg07936489 chr17:37558343 FBXL20 -0.46 -6.63 -0.34 1.4e-10 Asthma; CRC trans rs916888 0.821 rs70602 chr17:44859715 T/C cg22968622 chr17:43663579 NA -1.2 -15.72 -0.65 6.5e-42 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs4974559 0.947 rs58750335 chr4:1364764 G/A cg02980000 chr4:1222292 CTBP1 0.73 7.39 0.38 1.23e-12 Systolic blood pressure; CRC cis rs2971970 0.519 rs6968008 chr7:133632324 C/T cg03336402 chr7:133662267 EXOC4 0.63 9.63 0.47 1.65e-19 Intelligence (multi-trait analysis); CRC cis rs728616 0.558 rs12414691 chr10:82156982 A/T cg11900509 chr10:81946545 ANXA11 -0.56 -6.24 -0.33 1.32e-9 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs6502050 0.799 rs4132775 chr17:80155412 C/T cg13198984 chr17:80129470 CCDC57 0.42 7.29 0.37 2.32e-12 Life satisfaction; CRC cis rs35520189 0.591 rs12466604 chr2:113703064 G/A cg12858261 chr2:113808755 IL1F8 0.49 6.87 0.35 3.29e-11 Obstructive sleep apnea trait (apnea hypopnea index); CRC cis rs28719689 0.527 rs6558435 chr8:1215445 C/T cg03565240 chr8:1204483 NA -0.44 -5.7 -0.3 2.68e-8 Colonoscopy-negative controls vs population controls; CRC cis rs7209700 0.547 rs55845779 chr17:45354751 G/A cg08085267 chr17:45401833 C17orf57 0.54 6.4 0.33 5.22e-10 IgG glycosylation; CRC cis rs7666738 0.830 rs13102652 chr4:99006737 T/G cg05340658 chr4:99064831 C4orf37 0.61 9.54 0.47 3.44e-19 Colonoscopy-negative controls vs population controls; CRC cis rs9322193 0.923 rs10747276 chr6:150079875 G/A cg04369109 chr6:150039330 LATS1 -0.43 -5.94 -0.31 7.13e-9 Lung cancer; CRC cis rs34172651 0.517 rs3803716 chr16:24802325 C/T cg04756594 chr16:24857601 SLC5A11 0.33 6.8 0.35 5.08e-11 Intelligence (multi-trait analysis); CRC cis rs7208859 0.573 rs7223803 chr17:29077193 A/G cg13385521 chr17:29058706 SUZ12P 0.72 8.24 0.41 4.19e-15 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs4803480 0.935 rs758349 chr19:42085106 T/C cg08478046 chr19:42093086 CEACAM21 -0.31 -5.65 -0.3 3.46e-8 Schizophrenia; CRC cis rs4666002 0.636 rs2272406 chr2:27892023 A/T cg27432699 chr2:27873401 GPN1 0.56 6.96 0.36 1.86e-11 Phospholipid levels (plasma); CRC cis rs3768617 0.811 rs12120747 chr1:183042531 G/A ch.1.3577855R chr1:183094577 LAMC1 0.62 9.04 0.45 1.41e-17 Fuchs's corneal dystrophy; CRC cis rs10504229 0.511 rs75967910 chr8:58024231 C/G cg24829409 chr8:58192753 C8orf71 -0.56 -6.81 -0.35 4.64e-11 Developmental language disorder (linguistic errors); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg21317428 chr17:1157267 NA 0.35 6.05 0.32 3.98e-9 Liver disease severity in Alagille syndrome; CRC trans rs62295889 0.602 rs6448916 chr4:12546096 C/T cg03490839 chr16:73082051 ZFHX3 0.57 6.0 0.31 5.21e-9 Obesity-related traits; CRC cis rs1707322 1.000 rs6675222 chr1:46326576 G/T cg03146154 chr1:46216737 IPP 0.5 6.95 0.36 1.97e-11 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs16867321 0.614 rs12693245 chr2:181445110 T/C cg23363182 chr2:181467187 NA 0.59 9.05 0.45 1.29e-17 Obesity; CRC cis rs7474896 0.515 rs2738203 chr10:38277596 G/A cg25427524 chr10:38739819 LOC399744 0.66 7.86 0.4 5.53e-14 Obesity (extreme); CRC cis rs4925325 0.956 rs1776263 chr20:60515820 A/G cg06108461 chr20:60628389 TAF4 -0.55 -7.29 -0.37 2.27e-12 Obesity-related traits; CRC cis rs1008375 0.933 rs4698637 chr4:17632843 A/T cg04450456 chr4:17643702 FAM184B 0.41 6.29 0.33 1e-9 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs3733585 0.631 rs4697924 chr4:10124239 A/G cg11266682 chr4:10021025 SLC2A9 -0.43 -7.68 -0.39 1.88e-13 Cleft plate (environmental tobacco smoke interaction); CRC cis rs873946 0.504 rs3793681 chr10:134564451 T/C cg26818010 chr10:134567672 INPP5A -0.61 -8.47 -0.42 8.56e-16 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CRC cis rs853679 1.000 rs1679709 chr6:28228342 A/G cg03623178 chr6:28175578 NA -0.67 -6.77 -0.35 6e-11 Depression; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg05477027 chr19:46295590 DMWD 0.44 6.14 0.32 2.37e-9 Response to antipsychotic treatment; CRC cis rs9303280 0.806 rs12232498 chr17:38040363 T/C cg17467752 chr17:38218738 THRA -0.37 -5.65 -0.3 3.39e-8 Self-reported allergy; CRC cis rs7192750 0.517 rs152827 chr16:72126753 C/G cg14768367 chr16:72042858 DHODH 0.85 6.44 0.33 4.18e-10 LDL cholesterol levels;Total cholesterol levels; CRC cis rs3204270 0.714 rs79243595 chr17:79681220 T/C cg18367735 chr17:79674897 NA 0.51 5.82 0.31 1.37e-8 Dental caries; CRC cis rs4268898 0.760 rs4665675 chr2:24468132 C/T cg06627628 chr2:24431161 ITSN2 -0.43 -6.25 -0.33 1.3e-9 Asthma; CRC cis rs4253772 0.591 rs6008538 chr22:46685963 G/A cg24881330 chr22:46731750 TRMU 0.68 8.69 0.43 1.79e-16 LDL cholesterol;Cholesterol, total; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg23780514 chr18:71959249 CYB5A 0.49 6.67 0.35 1.06e-10 Thyroid stimulating hormone; CRC cis rs2404602 0.735 rs11072598 chr15:76764788 T/C cg03037974 chr15:76606532 NA -0.53 -7.59 -0.39 3.24e-13 Blood metabolite levels; CRC cis rs870825 0.616 rs6552801 chr4:185620623 G/A cg04058563 chr4:185651563 MLF1IP 0.72 9.38 0.46 1.12e-18 Blood protein levels; CRC cis rs11122272 0.705 rs2808599 chr1:231533482 T/C cg06096015 chr1:231504339 EGLN1 0.4 6.0 0.31 5.13e-9 Hemoglobin concentration; CRC cis rs7726839 0.540 rs3762951 chr5:662613 C/G cg16447950 chr5:562315 NA -0.76 -10.03 -0.48 7.77e-21 Obesity-related traits; CRC cis rs870825 0.616 rs7683537 chr4:185631998 T/C cg04058563 chr4:185651563 MLF1IP 0.73 9.38 0.46 1.13e-18 Blood protein levels; CRC cis rs7223966 1.000 rs2854218 chr17:61942940 A/G cg05941027 chr17:61774174 LIMD2 0.33 5.61 0.3 4.37e-8 Hip circumference adjusted for BMI;Body mass index; CRC cis rs1552244 1.000 rs9875081 chr3:10083935 G/A cg00166722 chr3:10149974 C3orf24 0.67 9.23 0.45 3.37e-18 Alzheimer's disease; CRC trans rs66573146 1.000 rs66712119 chr4:6965428 A/T cg07817883 chr1:32538562 TMEM39B 1.51 13.3 0.59 1.33e-32 Granulocyte percentage of myeloid white cells; CRC cis rs4713118 0.512 rs2622319 chr6:28120401 G/C cg15786705 chr6:28176104 NA 0.63 9.02 0.45 1.59e-17 Parkinson's disease; CRC cis rs7833790 0.654 rs6415652 chr8:82702257 G/A cg17211192 chr8:82754475 SNX16 -0.46 -6.16 -0.32 2.15e-9 Diastolic blood pressure; CRC cis rs968567 0.817 rs61896141 chr11:61556039 A/C cg14911132 chr11:61596755 FADS2 -0.57 -6.4 -0.33 5.45e-10 Blood metabolite levels;Rheumatoid arthritis;Vitiligo;Glycerophospholipid levels; CRC cis rs13191362 0.872 rs13206549 chr6:162978032 T/G cg21926612 chr6:163149169 PACRG;PARK2 0.82 10.31 0.49 8.66e-22 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs7894407 0.856 rs10883855 chr10:105092447 A/G cg05636881 chr10:105038444 INA 0.38 6.04 0.32 4.15e-9 White matter hyperintensity burden; CRC cis rs2274273 0.870 rs7158768 chr14:55763612 A/C cg23234261 chr14:55582407 NA -0.29 -5.84 -0.31 1.25e-8 Protein biomarker; CRC cis rs9916302 0.851 rs6503518 chr17:37660469 A/G cg15445000 chr17:37608096 MED1 0.42 9.31 0.46 1.91e-18 Glomerular filtration rate (creatinine); CRC cis rs6694672 0.867 rs4915337 chr1:197091537 A/T cg13682187 chr1:196946512 CFHR5 0.47 7.63 0.39 2.49e-13 Asthma; CRC cis rs9527 0.571 rs12219246 chr10:104613355 A/G cg08772003 chr10:104629869 AS3MT -0.36 -6.04 -0.32 4.07e-9 Arsenic metabolism; CRC cis rs28830936 1.000 rs9672360 chr15:41912411 T/C cg17847044 chr15:42102381 MAPKBP1 -0.29 -6.12 -0.32 2.6e-9 Diastolic blood pressure; CRC cis rs9303401 0.555 rs8073699 chr17:57236317 G/A cg10487724 chr17:56770010 TEX14;RAD51C 0.41 6.07 0.32 3.53e-9 Cognitive test performance; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg12056857 chr12:100593408 ACTR6 0.42 6.79 0.35 5.36e-11 Liver disease severity in Alagille syndrome; CRC trans rs2797369 0.713 rs4615398 chr6:101539082 C/T cg26346621 chr12:6873348 NA -0.4 -6.01 -0.31 4.87e-9 Renal function-related traits (eGRFcrea); CRC cis rs3736485 0.932 rs2278989 chr15:51914716 T/C cg08986416 chr15:51914746 DMXL2 -0.46 -6.52 -0.34 2.72e-10 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs7712401 0.791 rs1531340 chr5:122108017 G/A cg18764291 chr5:122110994 SNX2 0.42 6.69 0.35 9.63e-11 Mean platelet volume; CRC cis rs798554 0.679 rs13230995 chr7:2887284 G/A cg04166393 chr7:2884313 GNA12 0.55 7.71 0.39 1.48e-13 Height; CRC cis rs910316 0.737 rs108622 chr14:75481908 A/G cg08847533 chr14:75593920 NEK9 -0.85 -14.43 -0.62 6.29e-37 Height; CRC cis rs7394190 0.935 rs6480708 chr10:75420114 C/A cg26549892 chr10:75416844 SYNPO2L -0.5 -6.32 -0.33 8.46e-10 Incident atrial fibrillation; CRC cis rs758324 0.812 rs3756287 chr5:131135478 A/G cg25547332 chr5:131281432 NA 0.36 5.75 0.3 2.08e-8 Alzheimer's disease in APOE e4- carriers; CRC cis rs9768139 0.935 rs7800718 chr7:158121878 G/A cg06219351 chr7:158114137 PTPRN2 0.44 6.49 0.34 3.14e-10 Calcium levels; CRC cis rs1580019 0.844 rs1901202 chr7:32503724 A/T cg07520158 chr7:32535189 LSM5;AVL9 0.49 6.7 0.35 8.88e-11 Cognitive ability; CRC cis rs2252521 0.583 rs161050 chr7:29099273 A/G cg11728747 chr7:29037910 CPVL -0.48 -6.93 -0.36 2.28e-11 Cognitive performance; CRC cis rs798554 0.836 rs798500 chr7:2790685 C/T cg19346786 chr7:2764209 NA 0.43 7.71 0.39 1.48e-13 Height; CRC cis rs8177253 1.000 rs8177240 chr3:133477701 T/G cg11941060 chr3:133502564 NA -0.58 -10.14 -0.49 3.43e-21 Iron status biomarkers; CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg01994328 chr10:30723347 MAP3K8 0.38 6.19 0.32 1.84e-9 Obesity-related traits; CRC cis rs7429990 0.965 rs9846062 chr3:47998966 A/G cg11946769 chr3:48343235 NME6 0.45 5.89 0.31 9.52e-9 Educational attainment (years of education); CRC cis rs644799 1.000 rs566204 chr11:95580926 G/A cg25478527 chr11:95522999 CEP57;FAM76B 0.51 7.75 0.39 1.18e-13 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs9467773 0.626 rs9379860 chr6:26370605 T/C cg09904177 chr6:26538194 HMGN4 -0.45 -6.28 -0.33 1.06e-9 Intelligence (multi-trait analysis); CRC trans rs1814175 0.645 rs28627251 chr11:50048125 G/T cg03929089 chr4:120376271 NA -0.89 -16.04 -0.66 3.41e-43 Height; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg15427393 chr19:44037695 ZNF575 0.45 6.17 0.32 1.96e-9 Anxiety disorder; CRC cis rs4664293 0.867 rs10166694 chr2:160594891 A/G cg08347373 chr2:160653686 CD302 -0.47 -7.43 -0.38 9.32e-13 Monocyte percentage of white cells; CRC cis rs9910055 0.762 rs1135215 chr17:42253519 T/C cg10896456 chr17:42255109 ASB16;C17orf65 0.45 7.23 0.37 3.37e-12 Total body bone mineral density; CRC cis rs10504229 0.683 rs11774645 chr8:58132921 G/C cg22535103 chr8:58192502 C8orf71 -0.73 -8.34 -0.42 2.06e-15 Developmental language disorder (linguistic errors); CRC trans rs8073060 0.855 rs12150450 chr17:33868896 A/T cg19694781 chr19:47549865 TMEM160 0.54 7.91 0.4 3.94e-14 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; CRC cis rs2836974 0.931 rs7283569 chr21:40644062 T/G cg06238570 chr21:40685208 BRWD1 0.79 10.86 0.51 1.11e-23 Cognitive function; CRC cis rs2274273 0.624 rs7150763 chr14:55839801 A/G cg10130446 chr14:55658398 DLGAP5 -0.44 -6.26 -0.33 1.18e-9 Protein biomarker; CRC cis rs2120019 0.938 rs13056 chr15:75312187 A/G cg09165964 chr15:75287851 SCAMP5 -0.86 -13.46 -0.6 3.28e-33 Blood trace element (Zn levels); CRC cis rs875971 1.000 rs778706 chr7:65860424 A/G cg11764359 chr7:65958608 NA 0.61 9.95 0.48 1.41e-20 Aortic root size; CRC cis rs7927592 0.763 rs11822059 chr11:68300822 T/G cg01657329 chr11:68192670 LRP5 -0.55 -9.04 -0.45 1.37e-17 Total body bone mineral density; CRC trans rs7615952 0.576 rs12497295 chr3:125818650 G/A cg07211511 chr3:129823064 LOC729375 -0.69 -9.08 -0.45 1.02e-17 Blood pressure (smoking interaction); CRC cis rs17818399 0.547 rs12997164 chr2:46758746 A/C cg26688816 chr2:46740690 ATP6V1E2 -0.46 -5.99 -0.31 5.37e-9 Height; CRC cis rs6921919 0.848 rs6903652 chr6:28322120 C/G cg21251018 chr6:28226885 NKAPL 0.41 5.78 0.3 1.77e-8 Autism spectrum disorder or schizophrenia; CRC cis rs644799 1.000 rs505220 chr11:95563228 T/G cg03916912 chr11:95522834 CEP57;FAM76B 0.95 18.38 0.71 2.03e-52 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs1448094 1.000 rs4919776 chr12:86353763 T/C cg02569458 chr12:86230093 RASSF9 0.38 6.36 0.33 6.76e-10 Major depressive disorder; CRC cis rs7914558 1.000 rs11191577 chr10:104902165 A/G cg04362960 chr10:104952993 NT5C2 0.59 8.75 0.43 1.14e-16 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs3823572 0.564 rs2346274 chr7:133660841 G/A cg03336402 chr7:133662267 EXOC4 -0.67 -10.62 -0.51 7.59e-23 Intelligence (multi-trait analysis); CRC cis rs9399135 0.967 rs6902438 chr6:135336587 C/T cg22676075 chr6:135203613 NA 0.4 6.25 0.33 1.27e-9 Red blood cell count; CRC cis rs3857536 0.813 rs2093253 chr6:66937702 A/G cg07460842 chr6:66804631 NA -0.43 -5.81 -0.3 1.48e-8 Blood trace element (Cu levels); CRC cis rs926938 0.552 rs360613 chr1:115394864 C/G cg12756093 chr1:115239321 AMPD1 0.52 7.97 0.4 2.59e-14 Autism; CRC cis rs10140922 0.567 rs2415263 chr14:35630319 A/C cg07166546 chr14:35805898 NA 0.28 5.67 0.3 3.12e-8 Hip circumference adjusted for BMI; CRC cis rs1218582 0.774 rs4845679 chr1:154861187 G/T cg09359103 chr1:154839909 KCNN3 -0.74 -13.15 -0.59 4.94e-32 Prostate cancer; CRC cis rs3785574 0.962 rs2247435 chr17:61892862 G/A cg06601766 chr17:61851465 DDX42;CCDC47 0.6 8.45 0.42 9.3e-16 Height; CRC cis rs478304 0.903 rs495961 chr11:65540886 C/T cg27068330 chr11:65405492 SIPA1 0.44 6.51 0.34 2.78e-10 Acne (severe); CRC cis rs832540 0.629 rs10461616 chr5:56080347 T/C cg03609598 chr5:56110824 MAP3K1 -0.44 -5.82 -0.31 1.37e-8 Coronary artery disease; CRC cis rs7746199 0.736 rs6904596 chr6:27491299 G/A cg15845792 chr6:28175446 NA 0.77 6.18 0.32 1.93e-9 Gait speed in old age;Autism spectrum disorder or schizophrenia; CRC cis rs924607 0.898 rs1697990 chr5:626278 A/G cg04476341 chr5:669733 TPPP -0.42 -6.85 -0.35 3.53e-11 Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia; CRC cis rs798554 0.836 rs798502 chr7:2789880 G/T cg19346786 chr7:2764209 NA 0.38 6.64 0.34 1.26e-10 Height; CRC cis rs1218582 0.772 rs10908448 chr1:154882544 A/G cg06221963 chr1:154839813 KCNN3 0.77 15.65 0.65 1.23e-41 Prostate cancer; CRC cis rs12497850 0.897 rs7432989 chr3:49105136 A/G cg20833759 chr3:49053208 WDR6;DALRD3 0.54 9.25 0.45 2.96e-18 Parkinson's disease; CRC cis rs4478858 0.735 rs6676354 chr1:31800746 A/T cg00250761 chr1:31883323 NA -0.44 -8.5 -0.42 6.71e-16 Alcohol dependence; CRC cis rs832540 0.618 rs2548663 chr5:56172778 G/A cg18230493 chr5:56204884 C5orf35 -0.4 -5.65 -0.3 3.43e-8 Coronary artery disease; CRC cis rs7503807 0.515 rs12939413 chr17:78679449 C/T cg00549398 chr17:78725201 RPTOR 0.43 5.77 0.3 1.86e-8 Obesity; CRC cis rs12701220 0.689 rs6973645 chr7:1112246 C/T cg26769984 chr7:1090371 C7orf50 0.54 6.94 0.36 2.12e-11 Bronchopulmonary dysplasia; CRC cis rs965469 0.947 rs6037529 chr20:3261006 C/T cg25506879 chr20:3388711 C20orf194 -0.4 -5.91 -0.31 8.35e-9 IFN-related cytopenia; CRC cis rs10504229 0.593 rs75047131 chr8:58001320 A/G cg21724239 chr8:58056113 NA 0.77 9.69 0.47 1.08e-19 Developmental language disorder (linguistic errors); CRC cis rs7617773 0.817 rs6796490 chr3:48237104 A/C cg11946769 chr3:48343235 NME6 0.49 6.78 0.35 5.75e-11 Coronary artery disease; CRC cis rs6724607 1.000 rs28452331 chr2:191471847 C/T cg21644426 chr2:191273491 MFSD6 -0.44 -5.84 -0.31 1.23e-8 Pulse pressure; CRC cis rs736408 0.648 rs3774354 chr3:52817675 G/A cg18099408 chr3:52552593 STAB1 -0.44 -6.81 -0.35 4.61e-11 Bipolar disorder; CRC cis rs10128264 1.000 rs2802364 chr10:80960486 G/C cg20744163 chr10:80999841 ZMIZ1 -0.42 -7.33 -0.37 1.8e-12 Response to methotrexate in juvenile idiopathic arthritis; CRC cis rs2637266 0.539 rs11001888 chr10:78572048 C/G cg18941641 chr10:78392320 NA -0.35 -5.85 -0.31 1.21e-8 Pulmonary function; CRC cis rs2282802 0.685 rs2337081 chr5:139642414 A/C cg26211634 chr5:139558579 C5orf32 0.41 6.94 0.36 2.15e-11 Intelligence (multi-trait analysis); CRC cis rs875971 0.862 rs6978028 chr7:65886300 G/C cg12463550 chr7:65579703 CRCP 0.48 6.52 0.34 2.72e-10 Aortic root size; CRC trans rs7395662 1.000 rs7949348 chr11:48493801 G/C cg21153622 chr11:89784906 NA -0.5 -8.0 -0.4 2.09e-14 HDL cholesterol; CRC cis rs4523957 0.893 rs9909895 chr17:2161633 G/A cg16513277 chr17:2031491 SMG6 -0.53 -8.76 -0.43 1.07e-16 Autism spectrum disorder or schizophrenia;Schizophrenia; CRC cis rs796364 0.951 rs11680258 chr2:200996976 T/C cg25936922 chr2:200820526 C2orf60;C2orf47 -0.65 -7.25 -0.37 3.08e-12 Schizophrenia; CRC cis rs4481887 0.504 rs7522945 chr1:248357857 C/A cg00666640 chr1:248458726 OR2T12 0.43 6.98 0.36 1.61e-11 Common traits (Other); CRC cis rs4664308 1.000 rs6719686 chr2:160908292 T/G cg03641300 chr2:160917029 PLA2R1 -0.75 -12.46 -0.57 1.81e-29 Idiopathic membranous nephropathy; CRC cis rs1552244 0.572 rs41464050 chr3:10158393 A/G cg16606324 chr3:10149918 C3orf24 0.67 7.89 0.4 4.39e-14 Alzheimer's disease; CRC cis rs782590 0.902 rs782600 chr2:55848040 T/C cg18811423 chr2:55921094 PNPT1 0.79 14.08 0.61 1.43e-35 Metabolic syndrome; CRC cis rs12477438 0.520 rs2632276 chr2:99779655 C/A cg26064155 chr2:99771622 LIPT1;TSGA10 0.83 14.32 0.62 1.75e-36 Chronic sinus infection; CRC trans rs1814175 0.817 rs1621090 chr11:49895868 C/A cg15704280 chr7:45808275 SEPT13 -1.02 -20.55 -0.75 6.02e-61 Height; CRC cis rs34864796 0.547 rs200476 chr6:27768348 A/T cg19041857 chr6:27730383 NA -0.48 -6.12 -0.32 2.68e-9 Lung function (FEV1);Lung function (FEV1/FVC);Lung function (FVC); CRC cis rs7258465 1.000 rs4808136 chr19:18618867 A/G cg10790698 chr19:18539756 SSBP4 0.43 8.12 0.41 9.54e-15 Breast cancer; CRC cis rs7044106 0.762 rs1867254 chr9:123429078 C/T cg09419670 chr9:123605666 PSMD5;LOC253039 0.69 10.66 0.51 5.53e-23 Hip circumference adjusted for BMI; CRC cis rs1448094 0.817 rs10863122 chr12:86346047 T/C cg25456477 chr12:86230367 RASSF9 0.33 5.63 0.3 3.87e-8 Major depressive disorder; CRC cis rs4631830 0.900 rs10763546 chr10:51536399 C/G cg20129853 chr10:51489980 NA -0.36 -5.87 -0.31 1.08e-8 Prostate-specific antigen levels; CRC cis rs7762018 0.882 rs4716342 chr6:170137959 A/G cg17545662 chr6:170176663 C6orf70 0.51 5.68 0.3 2.97e-8 Thiazide-induced adverse metabolic effects in hypertensive patients; CRC cis rs6598955 0.671 rs12142535 chr1:26589698 T/A cg04990556 chr1:26633338 UBXN11 0.56 6.02 0.32 4.53e-9 Obesity-related traits; CRC cis rs11716531 0.504 rs648103 chr3:27550301 T/C cg02860705 chr3:27208620 NA -0.43 -6.53 -0.34 2.52e-10 Diastolic blood pressure; CRC cis rs2197308 0.655 rs1971964 chr12:37870474 C/T cg26384229 chr12:38710491 ALG10B 0.67 8.79 0.44 8.51e-17 Morning vs. evening chronotype; CRC cis rs6502050 0.835 rs8065565 chr17:80115399 A/G cg13198984 chr17:80129470 CCDC57 0.46 8.18 0.41 6.3e-15 Life satisfaction; CRC cis rs11587400 0.634 rs7553926 chr1:115202215 A/G cg12756093 chr1:115239321 AMPD1 -0.44 -6.12 -0.32 2.7e-9 Autism; CRC cis rs9443645 0.901 rs9352675 chr6:79612800 G/A cg11833968 chr6:79620685 NA -0.37 -6.48 -0.34 3.34e-10 Intelligence (multi-trait analysis); CRC cis rs6952808 0.601 rs3800882 chr7:2120758 G/A cg18279126 chr7:2041391 MAD1L1 0.39 6.11 0.32 2.81e-9 Bipolar disorder and schizophrenia; CRC cis rs6831352 0.879 rs17218003 chr4:100054723 G/C cg12011299 chr4:100065546 ADH4 -0.49 -9.27 -0.45 2.61e-18 Alcohol dependence; CRC cis rs12893668 0.572 rs7148857 chr14:104143237 C/G cg01849466 chr14:104193079 ZFYVE21 -0.41 -6.05 -0.32 3.98e-9 Reticulocyte count; CRC cis rs10479542 0.896 rs4701131 chr5:178982446 A/G cg22764044 chr5:178986830 RUFY1 0.43 7.59 0.39 3.36e-13 Lung cancer; CRC cis rs877282 1.000 rs11253367 chr10:773389 G/A cg17470449 chr10:769945 NA 0.64 9.26 0.45 2.73e-18 Uric acid levels; CRC cis rs1552244 1.000 rs7611218 chr3:10063960 T/C cg08888203 chr3:10149979 C3orf24 0.69 9.69 0.47 1.04e-19 Alzheimer's disease; CRC cis rs7072216 0.922 rs59667296 chr10:100146313 A/T cg26618903 chr10:100175079 PYROXD2 -0.38 -6.6 -0.34 1.66e-10 Metabolite levels; CRC trans rs7395662 1.000 rs11039820 chr11:48562252 A/G cg21153622 chr11:89784906 NA -0.44 -7.06 -0.36 9.71e-12 HDL cholesterol; CRC cis rs6120849 0.754 rs6120788 chr20:33583716 C/T cg24642439 chr20:33292090 TP53INP2 0.46 5.93 0.31 7.49e-9 Protein C levels; CRC cis rs1728785 0.901 rs1170438 chr16:68608256 T/C cg02972257 chr16:68554789 NA -0.6 -7.28 -0.37 2.46e-12 Ulcerative colitis; CRC cis rs941408 0.515 rs1640262 chr19:2779134 C/T cg17333051 chr19:2783644 SGTA -0.43 -6.93 -0.36 2.18e-11 Total cholesterol levels; CRC cis rs7119 0.931 rs62009087 chr15:77833064 C/T cg10437265 chr15:77819839 NA 0.58 10.4 0.5 4.44e-22 Type 2 diabetes; CRC cis rs6545883 0.929 rs3732170 chr2:61749716 C/T cg15711740 chr2:61764176 XPO1 -0.52 -7.21 -0.37 3.81e-12 Tuberculosis; CRC cis rs9818758 0.607 rs35108630 chr3:49088356 T/A cg00383909 chr3:49044727 WDR6 1.31 12.49 0.57 1.46e-29 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; CRC cis rs6541297 1.000 rs6658942 chr1:230287517 A/C cg05784532 chr1:230284198 GALNT2 0.42 5.84 0.31 1.26e-8 Coronary artery disease; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg00142735 chr15:64454827 PPIB 0.43 5.99 0.31 5.42e-9 Response to antipsychotic treatment; CRC cis rs6424115 0.679 rs2076345 chr1:24083494 C/T cg08896387 chr1:24191740 FUCA1 0.49 6.27 0.33 1.14e-9 Immature fraction of reticulocytes; CRC cis rs9486715 0.867 rs12207471 chr6:96963782 A/G cg06623918 chr6:96969491 KIAA0776 1.03 20.52 0.75 7.72e-61 Headache; CRC cis rs9649213 0.593 rs7789380 chr7:97956180 G/A cg21770322 chr7:97807741 LMTK2 0.51 8.29 0.42 2.88e-15 Prostate cancer (SNP x SNP interaction); CRC trans rs2303319 0.504 rs56100249 chr2:162415157 T/C cg14875682 chr5:52083620 ITGA1;PELO -0.79 -6.36 -0.33 6.65e-10 Cognitive function; CRC cis rs7618915 0.547 rs6976 chr3:52728804 C/T cg08222913 chr3:52553049 STAB1 -0.34 -5.97 -0.31 6.17e-9 Bipolar disorder; CRC cis rs7937682 0.824 rs539524 chr11:111477325 A/G cg09085632 chr11:111637200 PPP2R1B -1.0 -19.99 -0.74 9.26e-59 Primary sclerosing cholangitis; CRC cis rs929354 0.742 rs7801905 chr7:156940111 T/C cg05182265 chr7:156933206 UBE3C -0.76 -14.38 -0.62 1.04e-36 Body mass index; CRC cis rs28386778 0.897 rs2854214 chr17:61945449 C/G cg23090583 chr17:61904693 PSMC5;FTSJ3 -1.03 -19.61 -0.73 2.95e-57 Prudent dietary pattern; CRC cis rs6952808 0.825 rs11761818 chr7:1935273 C/T cg20295408 chr7:1910781 MAD1L1 -0.43 -6.12 -0.32 2.71e-9 Bipolar disorder and schizophrenia; CRC cis rs4253772 0.530 rs11090865 chr22:46731689 G/T cg03482458 chr22:46692211 CN5H6.4;GTSE1 0.5 5.8 0.3 1.52e-8 LDL cholesterol;Cholesterol, total; CRC cis rs1891275 0.515 rs1418161 chr10:93484655 C/G cg07889827 chr10:93443413 NA -0.39 -6.5 -0.34 3.05e-10 Intelligence (multi-trait analysis); CRC cis rs9549328 0.670 rs2993344 chr13:113617022 C/T cg25790453 chr13:113633590 MCF2L 0.44 7.66 0.39 2.09e-13 Systolic blood pressure; CRC cis rs7811142 1.000 rs11773661 chr7:100073069 G/C cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.17 16.82 0.68 2.91e-46 Platelet count; CRC cis rs4713118 0.662 rs9393881 chr6:28023751 C/G cg12172441 chr6:28176163 NA 0.55 6.94 0.36 2.05e-11 Parkinson's disease; CRC cis rs10504073 0.647 rs10957357 chr8:49988587 C/A cg00325661 chr8:49890786 NA 0.49 8.74 0.43 1.18e-16 Blood metabolite ratios; CRC cis rs7666738 0.753 rs13122897 chr4:98936185 C/A cg05340658 chr4:99064831 C4orf37 0.6 9.35 0.46 1.41e-18 Colonoscopy-negative controls vs population controls; CRC cis rs10752881 1.000 rs4402094 chr1:182986441 G/A ch.1.3577855R chr1:183094577 LAMC1 0.86 15.22 0.64 5.91e-40 Colorectal cancer; CRC cis rs10197940 0.624 rs13393122 chr2:152413315 A/G cg19508488 chr2:152266495 RIF1 0.53 7.33 0.37 1.79e-12 Lung cancer; CRC cis rs28386778 0.863 rs2584637 chr17:61942952 T/C cg22520471 chr17:61851767 DDX42;CCDC47 0.74 11.44 0.53 9.46e-26 Prudent dietary pattern; CRC cis rs11214589 0.747 rs10891537 chr11:113211370 A/C cg14159747 chr11:113255604 NA 0.49 8.92 0.44 3.24e-17 Neuroticism; CRC cis rs10504229 0.728 rs59266065 chr8:58156236 A/G cg11062466 chr8:58055876 NA 0.45 5.88 0.31 1.01e-8 Developmental language disorder (linguistic errors); CRC cis rs425277 0.583 rs1467217 chr1:2045165 G/A cg24578937 chr1:2090814 PRKCZ -0.39 -7.17 -0.37 4.86e-12 Height; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg02309717 chr12:32908817 YARS2 0.51 6.56 0.34 2.13e-10 Thyroid stimulating hormone; CRC trans rs7647973 0.626 rs11130217 chr3:49737323 A/G cg21665057 chr3:196295764 WDR53;FBXO45 -0.63 -6.99 -0.36 1.57e-11 Menarche (age at onset); CRC cis rs561341 0.941 rs72825746 chr17:30364610 G/A cg19193384 chr17:30244184 NA -0.64 -7.46 -0.38 7.99e-13 Hip circumference adjusted for BMI; CRC cis rs7746199 0.668 rs7749305 chr6:27446566 T/C cg15845792 chr6:28175446 NA 0.77 6.2 0.32 1.67e-9 Gait speed in old age;Autism spectrum disorder or schizophrenia; CRC cis rs270601 0.690 rs162907 chr5:131580152 A/G cg27615366 chr5:131592974 PDLIM4 -0.34 -6.08 -0.32 3.36e-9 Acylcarnitine levels; CRC cis rs3617 0.625 rs7612624 chr3:52893426 T/C cg07507251 chr3:52567010 NT5DC2 -0.41 -6.43 -0.33 4.59e-10 Red blood cell count;Autism spectrum disorder or schizophrenia; CRC cis rs10503871 0.816 rs3779639 chr8:30407991 A/G cg26383811 chr8:30366931 RBPMS -0.44 -7.2 -0.37 4.18e-12 Metabolite levels (X-11787); CRC cis rs1552244 1.000 rs6764068 chr3:10153842 A/G cg10729496 chr3:10149963 C3orf24 0.54 7.0 0.36 1.41e-11 Alzheimer's disease; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg05986781 chr7:127291658 SND1 0.47 6.01 0.31 4.96e-9 Thyroid stimulating hormone; CRC cis rs3764563 0.935 rs4807958 chr19:15718042 T/C cg20725493 chr19:15740067 CYP4F8 -0.68 -6.21 -0.32 1.64e-9 Inflammatory biomarkers; CRC cis rs4253772 0.591 rs6008365 chr22:46652929 G/A cg09491104 chr22:46646882 C22orf40 -0.45 -7.06 -0.36 1e-11 LDL cholesterol;Cholesterol, total; CRC cis rs1865760 1.000 rs7739966 chr6:25906040 T/C cg17691542 chr6:26056736 HIST1H1C 0.55 8.35 0.42 1.88e-15 Height; CRC cis rs1215050 0.755 rs2952911 chr4:98850666 T/C cg05340658 chr4:99064831 C4orf37 -0.48 -7.21 -0.37 3.82e-12 Waist-to-hip ratio adjusted for body mass index; CRC cis rs28386778 0.897 rs2584640 chr17:61863488 C/T cg23090583 chr17:61904693 PSMC5;FTSJ3 1.05 20.71 0.75 1.47e-61 Prudent dietary pattern; CRC cis rs3733585 0.673 rs7375587 chr4:9954758 A/T cg00071950 chr4:10020882 SLC2A9 0.53 9.39 0.46 1.03e-18 Cleft plate (environmental tobacco smoke interaction); CRC cis rs7089973 0.872 rs7909566 chr10:116629136 A/G cg03647239 chr10:116582469 FAM160B1 0.41 5.79 0.3 1.67e-8 Bipolar disorder or attention deficit hyperactivity disorder; CRC cis rs477895 0.713 rs11600867 chr11:63972052 T/A cg19465662 chr11:63993652 NUDT22;TRPT1 0.77 9.36 0.46 1.28e-18 Mean platelet volume; CRC cis rs832540 0.593 rs252912 chr5:56195792 C/T cg18230493 chr5:56204884 C5orf35 -0.41 -5.93 -0.31 7.58e-9 Coronary artery disease; CRC cis rs6499255 1.000 rs4497676 chr16:69814950 G/A cg04110750 chr16:69646130 NFAT5 -0.49 -6.5 -0.34 2.99e-10 IgE levels; CRC cis rs875971 0.502 rs2946580 chr7:65531842 G/A cg03233332 chr7:66118400 NA 0.45 6.16 0.32 2.08e-9 Aortic root size; CRC cis rs12249377 0.519 rs4520504 chr10:92602373 T/C cg14313238 chr10:92632228 RPP30 0.45 6.29 0.33 1.03e-9 White matter microstructure (global fractional anisotropy); CRC cis rs2276314 0.857 rs62101402 chr18:33629435 A/G cg05985134 chr18:33552581 C18orf21 0.46 6.32 0.33 8.28e-10 Endometriosis;Drug-induced torsades de pointes; CRC cis rs2075371 0.932 rs11766132 chr7:133993062 T/C cg20476274 chr7:133979776 SLC35B4 0.74 12.51 0.57 1.18e-29 Mean platelet volume; CRC cis rs9303401 0.625 rs10515159 chr17:56802693 G/C cg10487724 chr17:56770010 TEX14;RAD51C 0.79 10.0 0.48 1.01e-20 Cognitive test performance; CRC cis rs12824058 0.831 rs12829373 chr12:130814114 G/C cg26677194 chr12:130822605 PIWIL1 0.44 7.2 0.37 4.02e-12 Menopause (age at onset); CRC cis rs7615952 0.641 rs7618515 chr3:125790578 C/T cg06494592 chr3:125709126 NA -0.56 -6.78 -0.35 5.65e-11 Blood pressure (smoking interaction); CRC trans rs11098499 0.570 rs6832740 chr4:120546136 T/C cg25214090 chr10:38739885 LOC399744 0.59 9.25 0.45 2.85e-18 Corneal astigmatism; CRC cis rs10782582 0.593 rs77208152 chr1:76124255 T/C cg03433033 chr1:76189801 ACADM -0.42 -6.1 -0.32 2.94e-9 Daytime sleep phenotypes; CRC trans rs7210990 0.724 rs178826 chr17:16083684 C/T cg24449302 chr15:66679100 MAP2K1 -0.43 -6.58 -0.34 1.87e-10 Neutrophil percentage of white cells;Lymphocyte percentage of white cells; CRC cis rs758324 0.738 rs648304 chr5:131286708 T/C cg25547332 chr5:131281432 NA -0.36 -5.79 -0.3 1.61e-8 Alzheimer's disease in APOE e4- carriers; CRC cis rs2579500 0.844 rs2579503 chr2:97176634 A/G cg23100626 chr2:96804247 ASTL -0.23 -5.6 -0.3 4.49e-8 Eosinophil counts;Eosinophil percentage of white cells; CRC cis rs763014 0.932 rs2384975 chr16:651115 G/T cg07343612 chr16:622815 PIGQ -0.83 -14.54 -0.63 2.35e-37 Height; CRC trans rs1456896 0.796 rs1456895 chr7:50312228 G/A cg02134594 chr1:3632713 TP73 0.38 6.27 0.33 1.1e-9 Inflammatory bowel disease;Crohn's disease; CRC cis rs3733585 0.673 rs4312757 chr4:9956145 T/A cg11266682 chr4:10021025 SLC2A9 -0.47 -9.69 -0.47 1.05e-19 Cleft plate (environmental tobacco smoke interaction); CRC cis rs4665809 1.000 rs4665304 chr2:26313406 C/T cg27170947 chr2:26402098 FAM59B -0.47 -6.43 -0.33 4.55e-10 Gut microbiome composition (summer); CRC cis rs7618915 0.547 rs2336542 chr3:52710636 A/G cg18099408 chr3:52552593 STAB1 -0.44 -7.22 -0.37 3.66e-12 Bipolar disorder; CRC cis rs6484504 0.516 rs1999250 chr11:31287455 C/T cg14844989 chr11:31128820 NA -0.34 -6.04 -0.32 4.28e-9 Red blood cell count; CRC cis rs11190604 1.000 rs10883493 chr10:102208188 A/T cg16342193 chr10:102329863 NA -0.35 -5.83 -0.31 1.29e-8 Palmitoleic acid (16:1n-7) levels; CRC trans rs2303319 0.504 rs62189046 chr2:162612371 C/G cg27342122 chr8:133787442 PHF20L1 -0.72 -6.12 -0.32 2.68e-9 Cognitive function; CRC trans rs12599106 0.629 rs1391904 chr16:34548934 C/T cg15383120 chr6:291909 DUSP22 -0.51 -7.22 -0.37 3.54e-12 Menopause (age at onset); CRC cis rs694739 0.687 rs11231771 chr11:64140642 T/G cg23796481 chr11:64053134 BAD;GPR137 0.48 6.65 0.34 1.21e-10 Alopecia areata;Crohn's disease;Psoriasis vulgaris; CRC cis rs753778 0.667 rs10103731 chr8:142206068 C/T cg23750338 chr8:142222470 SLC45A4 0.45 7.42 0.38 1e-12 Reticulocyte fraction of red cells;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; CRC cis rs11711311 0.955 rs3796254 chr3:113380332 T/C cg15478005 chr3:113465772 ATP6V1A;NAA50 0.45 5.93 0.31 7.65e-9 IgG glycosylation; CRC cis rs2404602 0.647 rs4886837 chr15:77156417 A/G cg03037974 chr15:76606532 NA -0.55 -8.28 -0.42 3.21e-15 Blood metabolite levels; CRC cis rs950169 0.919 rs17300292 chr15:84762568 G/C cg11189052 chr15:85197271 WDR73 0.61 9.0 0.44 1.87e-17 Schizophrenia; CRC cis rs823143 0.570 rs1361754 chr1:205801872 C/T cg14159672 chr1:205819179 PM20D1 -0.61 -9.33 -0.46 1.66e-18 Monocyte percentage of white cells; CRC trans rs11039798 0.764 rs12277213 chr11:48782176 G/A cg03929089 chr4:120376271 NA 0.62 5.99 0.31 5.44e-9 Axial length; CRC cis rs16867321 0.694 rs11889207 chr2:181424527 A/C cg23363182 chr2:181467187 NA -0.58 -8.3 -0.42 2.8e-15 Obesity; CRC cis rs2933343 0.700 rs1683787 chr3:128627021 C/T cg11901034 chr3:128598214 ACAD9 0.55 7.82 0.4 7.08e-14 IgG glycosylation; CRC trans rs2727020 0.757 rs7924526 chr11:49267043 G/A cg15704280 chr7:45808275 SEPT13 0.68 9.35 0.46 1.41e-18 Coronary artery disease; CRC cis rs853679 0.713 rs200991 chr6:27815494 A/C cg20933634 chr6:27740509 NA -0.58 -6.8 -0.35 5e-11 Depression; CRC cis rs10256972 0.552 rs6978842 chr7:1204599 A/C cg26608667 chr7:1196370 ZFAND2A 0.41 6.69 0.35 9.64e-11 Longevity;Endometriosis; CRC cis rs6570726 0.905 rs406799 chr6:145821837 G/C cg05347473 chr6:146136440 FBXO30 0.37 6.0 0.31 5.27e-9 Lobe attachment (rater-scored or self-reported); CRC trans rs10838798 0.523 rs4752917 chr11:48241639 A/G cg15704280 chr7:45808275 SEPT13 -0.47 -6.7 -0.35 9.31e-11 Height; CRC cis rs427394 0.632 rs169285 chr5:6736587 G/C cg15145174 chr5:6755386 POLS -0.44 -6.49 -0.34 3.22e-10 Menopause (age at onset); CRC cis rs9649213 0.593 rs34129434 chr7:97926464 C/T cg21770322 chr7:97807741 LMTK2 0.5 8.23 0.41 4.49e-15 Prostate cancer (SNP x SNP interaction); CRC cis rs9372498 0.536 rs9489433 chr6:118867006 G/A cg18833306 chr6:118973337 C6orf204 0.45 5.95 0.31 6.95e-9 Diastolic blood pressure; CRC trans rs11466653 1.000 rs6852188 chr4:38778980 A/T cg11403706 chr22:49042600 FAM19A5 0.62 6.11 0.32 2.76e-9 Peripheral arterial disease (traffic-related air pollution interaction); CRC trans rs875971 0.660 rs2191268 chr7:66110224 C/T cg23976632 chr12:120875743 COX6A1 -0.4 -6.33 -0.33 8.04e-10 Aortic root size; CRC cis rs10256972 0.758 rs7799391 chr7:1082566 C/G cg18402987 chr7:1209562 NA 0.43 6.39 0.33 5.64e-10 Longevity;Endometriosis; CRC cis rs28655083 0.529 rs1847161 chr16:77097796 C/G cg01753188 chr16:77233325 SYCE1L;MON1B 0.49 7.08 0.36 8.81e-12 Lobe attachment (rater-scored or self-reported); CRC cis rs4731207 0.596 rs10257712 chr7:124598079 A/G cg23710748 chr7:124431027 NA -0.38 -5.97 -0.31 6.11e-9 Cutaneous malignant melanoma; CRC cis rs6952808 0.792 rs12536261 chr7:1953571 G/A cg02951883 chr7:2050386 MAD1L1 -0.69 -10.9 -0.52 7.69e-24 Bipolar disorder and schizophrenia; CRC cis rs6662572 1.000 rs11585275 chr1:46095989 T/C cg08644498 chr1:46502608 NA 0.43 6.0 0.31 5.2e-9 Blood protein levels; CRC cis rs6952808 0.723 rs55689856 chr7:2037215 G/A cg18279126 chr7:2041391 MAD1L1 0.39 5.78 0.3 1.76e-8 Bipolar disorder and schizophrenia; CRC cis rs1443512 0.947 rs1822438 chr12:54342326 A/C cg25382128 chr12:54346509 NA -0.39 -5.99 -0.31 5.5e-9 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for BMI in non-smokers;Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction);Waist-hip ratio;Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour); CRC cis rs12824058 0.831 rs4759655 chr12:130815740 A/G cg26677194 chr12:130822605 PIWIL1 -0.45 -7.24 -0.37 3.24e-12 Menopause (age at onset); CRC cis rs7727544 0.735 rs2631370 chr5:131703776 T/C cg04518342 chr5:131593106 PDLIM4 -0.32 -5.7 -0.3 2.67e-8 Blood metabolite levels; CRC cis rs4665809 1.000 rs750451 chr2:26324241 G/A cg26119090 chr2:26468346 HADHA;HADHB -0.61 -7.88 -0.4 4.97e-14 Gut microbiome composition (summer); CRC cis rs561341 1.000 rs576985 chr17:30323323 C/T cg23018236 chr17:30244563 NA -0.67 -8.03 -0.4 1.78e-14 Hip circumference adjusted for BMI; CRC cis rs6696846 0.765 rs61822568 chr1:205081166 C/G cg00857998 chr1:205179979 DSTYK 0.45 6.25 0.33 1.3e-9 Red blood cell count; CRC cis rs7264396 0.790 rs6058294 chr20:34259396 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.61 -10.31 -0.49 8.99e-22 Total cholesterol levels; CRC cis rs13108904 0.935 rs1620928 chr4:1279124 C/T cg19318889 chr4:1322082 MAEA -0.41 -6.05 -0.32 3.92e-9 Obesity-related traits; CRC cis rs10871290 0.650 rs2288054 chr16:74491733 A/G cg01733217 chr16:74700730 RFWD3 0.77 12.04 0.55 6.61e-28 Breast cancer; CRC cis rs2408955 0.561 rs9971924 chr12:48479832 C/G cg24011408 chr12:48396354 COL2A1 -0.44 -6.5 -0.34 3.05e-10 Glycated hemoglobin levels; CRC cis rs11098499 0.722 rs10025925 chr4:120271744 A/T cg24375607 chr4:120327624 NA 0.45 7.28 0.37 2.53e-12 Corneal astigmatism; CRC cis rs35110281 0.594 rs230641 chr21:44915441 T/C cg04455712 chr21:45112962 RRP1B -0.34 -6.23 -0.32 1.43e-9 Mean corpuscular volume; CRC cis rs2444240 1.000 rs494965 chr11:120053650 C/T cg16005559 chr11:120040616 NA -0.36 -5.84 -0.31 1.25e-8 Corneal curvature; CRC cis rs7833790 1.000 rs7833384 chr8:82730915 T/C cg27398817 chr8:82754497 SNX16 -0.52 -6.45 -0.34 3.98e-10 Diastolic blood pressure; CRC cis rs12791968 0.527 rs4755924 chr11:45013328 A/G cg11846598 chr11:44996168 LOC221122 -0.5 -6.58 -0.34 1.89e-10 Inhibitory control; CRC cis rs13256369 1.000 rs4840352 chr8:8573508 A/G cg06671706 chr8:8559999 CLDN23 0.57 8.29 0.42 2.89e-15 Obesity-related traits; CRC cis rs7586879 0.828 rs13387053 chr2:25103025 G/A cg04586622 chr2:25135609 ADCY3 -0.58 -9.98 -0.48 1.12e-20 Body mass index; CRC trans rs9328321 0.528 rs9378430 chr6:5574319 C/T cg27322103 chr7:23513335 NA -0.44 -6.25 -0.33 1.29e-9 Obesity (early onset extreme); CRC cis rs11690935 0.694 rs312921 chr2:172567225 T/C cg13550731 chr2:172543902 DYNC1I2 -1.09 -18.65 -0.72 1.85e-53 Schizophrenia; CRC cis rs11723261 0.621 rs6599307 chr4:143777 C/T cg12746427 chr4:53362 ZNF718;ZNF595 0.49 7.17 0.37 5.07e-12 Immune response to smallpox vaccine (IL-6); CRC cis rs12291225 0.585 rs4757250 chr11:14375683 C/A cg05501817 chr11:14380813 RRAS2 -0.48 -6.7 -0.35 8.95e-11 Sense of smell; CRC cis rs514406 0.825 rs7523761 chr1:53250915 T/C cg27535305 chr1:53392650 SCP2 0.38 7.22 0.37 3.52e-12 Monocyte count; CRC cis rs6032067 0.929 rs2267864 chr20:43805279 C/G cg10761708 chr20:43804764 PI3 0.48 5.6 0.3 4.48e-8 Blood protein levels; CRC cis rs12545109 0.800 rs1467125 chr8:57418638 C/T cg09654669 chr8:57350985 NA -0.4 -5.6 -0.3 4.49e-8 Obesity-related traits; CRC cis rs6831352 0.918 rs2851251 chr4:100044111 A/G cg12011299 chr4:100065546 ADH4 0.49 9.28 0.46 2.34e-18 Alcohol dependence; CRC cis rs35828350 1 rs35828350 chr15:85355841 G/A cg11189052 chr15:85197271 WDR73 0.56 7.53 0.38 5.02e-13 Autism spectrum disorder or schizophrenia; CRC cis rs11098499 0.954 rs3890049 chr4:120326283 T/A cg24375607 chr4:120327624 NA 0.51 7.87 0.4 5.24e-14 Corneal astigmatism; CRC cis rs67311347 1.000 rs9968170 chr3:40494274 A/G cg09455208 chr3:40491958 NA -0.39 -7.84 -0.4 6.35e-14 Renal cell carcinoma; CRC cis rs7726839 0.561 rs4957050 chr5:579066 A/C cg09021430 chr5:549028 NA -0.86 -10.87 -0.51 9.9e-24 Obesity-related traits; CRC cis rs4713118 0.629 rs203887 chr6:28021269 C/T cg06470822 chr6:28175283 NA 0.84 10.83 0.51 1.39e-23 Parkinson's disease; CRC cis rs7618915 0.571 rs11130307 chr3:52607682 G/A cg08222913 chr3:52553049 STAB1 -0.34 -6.29 -0.33 9.82e-10 Bipolar disorder; CRC cis rs10504229 0.683 rs11774847 chr8:58140775 T/A cg24829409 chr8:58192753 C8orf71 -0.68 -8.5 -0.42 6.62e-16 Developmental language disorder (linguistic errors); CRC cis rs2361718 0.967 rs12942941 chr17:78103013 C/T cg20811857 chr17:78079795 GAA -0.34 -5.6 -0.3 4.42e-8 Yeast infection; CRC cis rs2239547 0.522 rs4519686 chr3:52997871 C/T cg11645453 chr3:52864694 ITIH4 0.51 8.71 0.43 1.49e-16 Schizophrenia; CRC cis rs7647973 1.000 rs11719762 chr3:49409002 G/C cg20833759 chr3:49053208 WDR6;DALRD3 0.57 8.85 0.44 5.5e-17 Menarche (age at onset); CRC cis rs9435341 0.930 rs61798463 chr1:107565934 G/A cg09367891 chr1:107599246 PRMT6 0.66 9.79 0.47 4.99e-20 Facial morphology (factor 21, depth of nasal alae); CRC cis rs7223966 1.000 rs11871767 chr17:61698723 A/G cg23090583 chr17:61904693 PSMC5;FTSJ3 0.49 6.14 0.32 2.36e-9 Hip circumference adjusted for BMI;Body mass index; CRC cis rs9837602 1.000 rs704582 chr3:99571926 A/G cg07805332 chr3:99536008 MIR548G;C3orf26 -0.48 -6.38 -0.33 6.16e-10 Breast cancer; CRC cis rs35110281 0.563 rs162371 chr21:44931489 G/T cg04455712 chr21:45112962 RRP1B 0.38 7.27 0.37 2.71e-12 Mean corpuscular volume; CRC cis rs12477438 0.798 rs9679602 chr2:99577827 C/T cg14399236 chr2:99771627 LIPT1;TSGA10 0.69 9.64 0.47 1.58e-19 Chronic sinus infection; CRC cis rs9814567 1.000 rs4367113 chr3:134287975 G/A cg06541857 chr3:134203789 ANAPC13;CEP63 -0.38 -5.7 -0.3 2.62e-8 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC trans rs6600671 1.000 rs4844381 chr1:121184898 C/T cg17023122 chr1:144479586 NA 0.42 6.03 0.32 4.45e-9 Hip geometry; CRC cis rs6502050 0.835 rs8071425 chr17:80117335 C/T cg22110888 chr17:80059540 CCDC57 -0.39 -6.18 -0.32 1.92e-9 Life satisfaction; CRC cis rs6499255 1.000 rs4464069 chr16:69816284 C/T cg15192750 chr16:69999425 NA 0.48 6.42 0.33 4.81e-10 IgE levels; CRC trans rs9747201 0.926 rs34153075 chr17:80135728 C/A cg07393940 chr7:158741817 NA -0.53 -7.71 -0.39 1.53e-13 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs870825 0.616 rs72703531 chr4:185611092 C/T cg04058563 chr4:185651563 MLF1IP 0.73 8.12 0.41 9.21e-15 Blood protein levels; CRC cis rs17155006 0.718 rs370533 chr7:107746215 G/C cg05962710 chr7:107745446 LAMB4 -0.43 -7.58 -0.39 3.62e-13 Pneumococcal bacteremia; CRC cis rs12142240 0.698 rs17357676 chr1:46812444 A/G cg14993813 chr1:46806288 NSUN4 -0.51 -6.48 -0.34 3.28e-10 Menopause (age at onset); CRC trans rs208515 0.525 rs9453538 chr6:66668508 G/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.94 11.9 0.55 2.09e-27 Exhaled nitric oxide levels; CRC cis rs7772486 0.686 rs9497380 chr6:145955305 T/C cg23711669 chr6:146136114 FBXO30 0.66 10.8 0.51 1.79e-23 Lobe attachment (rater-scored or self-reported); CRC trans rs6011368 0.765 rs6062683 chr20:62891887 G/A cg13869341 chr1:15865 WASH5P 0.4 5.99 0.31 5.59e-9 Clozapine-induced cytotoxicity; CRC cis rs875971 0.522 rs1968127 chr7:66056803 C/T cg25985355 chr7:65971099 NA 0.32 5.71 0.3 2.54e-8 Aortic root size; CRC cis rs4319547 0.737 rs4758646 chr12:122946507 G/A cg23029597 chr12:123009494 RSRC2 -0.5 -6.82 -0.35 4.3e-11 Body mass index; CRC cis rs7618915 0.547 rs3755806 chr3:52643685 C/T cg15147215 chr3:52552868 STAB1 0.64 10.77 0.51 2.33e-23 Bipolar disorder; CRC cis rs2404602 0.716 rs1946650 chr15:76848463 T/C cg00316803 chr15:76480434 C15orf27 -0.35 -5.81 -0.31 1.46e-8 Blood metabolite levels; CRC cis rs9733 0.650 rs61820165 chr1:150555987 C/T cg17724175 chr1:150552817 MCL1 -0.51 -8.29 -0.42 2.96e-15 Tonsillectomy; CRC cis rs34172651 0.517 rs11639856 chr16:24788645 A/T cg04756594 chr16:24857601 SLC5A11 -0.31 -6.39 -0.33 5.75e-10 Intelligence (multi-trait analysis); CRC cis rs853679 0.517 rs55747925 chr6:28044337 T/C cg23161317 chr6:28129485 ZNF389 0.52 6.4 0.33 5.21e-10 Depression; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg21395782 chr19:19626814 NDUFA13;TSSK6 0.44 6.48 0.34 3.32e-10 Response to antipsychotic treatment; CRC cis rs6952808 0.825 rs4236277 chr7:1942270 C/T cg00106254 chr7:1943704 MAD1L1 -0.52 -7.76 -0.39 1.07e-13 Bipolar disorder and schizophrenia; CRC cis rs801193 0.935 rs2659916 chr7:66151352 C/G cg05627663 chr7:65219948 SNORA22;CCT6P1 0.44 6.43 0.33 4.53e-10 Aortic root size; CRC cis rs9894429 1.000 rs7406003 chr17:79597597 C/T cg21028142 chr17:79581711 NPLOC4 0.38 8.32 0.42 2.38e-15 Eye color traits; CRC cis rs9486715 0.838 rs6928442 chr6:96870118 A/G cg18709589 chr6:96969512 KIAA0776 0.47 7.01 0.36 1.34e-11 Headache; CRC cis rs3096299 0.658 rs12443705 chr16:89547054 C/G cg01788221 chr16:89496183 ANKRD11 -0.39 -5.71 -0.3 2.55e-8 Multiple myeloma (IgH translocation); CRC cis rs1552172 0.887 rs12750384 chr1:145681484 T/C cg25221984 chr1:145714143 CD160 -0.38 -5.71 -0.3 2.51e-8 Breast cancer; CRC cis rs6681460 0.966 rs1325261 chr1:67110516 G/A cg02459107 chr1:67143332 SGIP1 0.45 7.69 0.39 1.75e-13 Presence of antiphospholipid antibodies; CRC cis rs6804368 0.553 rs13078791 chr3:30766889 C/T cg06106510 chr3:30762233 NA 0.37 6.07 0.32 3.45e-9 Blood metabolite levels; CRC cis rs73206853 0.764 rs55991901 chr12:110962702 C/A cg12870014 chr12:110450643 ANKRD13A 0.71 7.68 0.39 1.86e-13 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC cis rs9611565 0.659 rs11090049 chr22:41915329 C/T cg06481639 chr22:41940642 POLR3H -0.51 -5.66 -0.3 3.27e-8 Vitiligo; CRC cis rs7178572 0.568 rs11853460 chr15:77515319 C/T cg22256960 chr15:77711686 NA -0.66 -9.57 -0.47 2.66e-19 Type 2 diabetes; CRC cis rs4862750 0.872 rs6852907 chr4:187897094 A/C cg11301795 chr4:187892539 NA -0.87 -19.83 -0.74 4.13e-58 Lobe attachment (rater-scored or self-reported); CRC cis rs1862618 0.853 rs861283 chr5:56184610 C/T cg18230493 chr5:56204884 C5orf35 -0.75 -9.27 -0.45 2.61e-18 Initial pursuit acceleration; CRC trans rs11148252 0.634 rs66849828 chr13:52714837 C/A cg18335740 chr13:41363409 SLC25A15 0.47 7.0 0.36 1.41e-11 Lewy body disease; CRC cis rs1728785 1.000 rs1728784 chr16:68591156 T/A cg02972257 chr16:68554789 NA -0.64 -7.52 -0.38 5.19e-13 Ulcerative colitis; CRC cis rs10733682 0.524 rs10987419 chr9:129462594 T/C cg00232160 chr9:129468157 NA 0.34 5.81 0.3 1.51e-8 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs4713118 0.869 rs9366700 chr6:27696951 C/T cg06470822 chr6:28175283 NA 0.71 10.07 0.49 5.85e-21 Parkinson's disease; CRC cis rs12291225 0.535 rs12806025 chr11:14413817 G/A cg19336497 chr11:14380999 RRAS2 -0.47 -8.08 -0.41 1.25e-14 Sense of smell; CRC cis rs7811142 0.943 rs67483801 chr7:100031758 G/T cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.02 14.75 0.63 3.76e-38 Platelet count; CRC trans rs6703335 0.870 rs10803142 chr1:243598234 A/G cg17780098 chr1:201476311 CSRP1 0.44 6.18 0.32 1.87e-9 Schizophrenia;Schizophrenia, schizoaffective disorder or bipolar disorder; CRC cis rs9611565 0.546 rs132793 chr22:42063681 A/G cg03806693 chr22:41940476 POLR3H 0.99 11.9 0.55 2.11e-27 Vitiligo; CRC cis rs1448094 0.511 rs7976647 chr12:86158766 A/G cg18827107 chr12:86230957 RASSF9 -0.38 -5.82 -0.31 1.37e-8 Major depressive disorder; CRC cis rs3768617 0.510 rs3818417 chr1:183079376 G/A ch.1.3577855R chr1:183094577 LAMC1 0.88 15.62 0.65 1.5e-41 Fuchs's corneal dystrophy; CRC cis rs1003719 0.679 rs2246285 chr21:38582431 G/A cg10648535 chr21:38446584 PIGP;TTC3 -0.46 -6.43 -0.33 4.57e-10 Eye color traits; CRC cis rs2180341 0.960 rs7773484 chr6:127670779 T/C cg24812749 chr6:127587940 RNF146 0.95 13.32 0.59 1.16e-32 Breast cancer; CRC cis rs7772486 0.558 rs702322 chr6:146007166 G/A cg23711669 chr6:146136114 FBXO30 -0.61 -8.87 -0.44 4.59e-17 Lobe attachment (rater-scored or self-reported); CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg01012308 chr16:3767753 TRAP1 0.46 6.36 0.33 6.63e-10 Anxiety disorder; CRC cis rs4862750 0.872 rs6836781 chr4:187899701 G/A cg07414643 chr4:187882934 NA 0.39 6.95 0.36 1.94e-11 Lobe attachment (rater-scored or self-reported); CRC cis rs6732160 0.588 rs1430345 chr2:73370682 A/G cg01422370 chr2:73384389 NA 0.4 6.35 0.33 6.95e-10 Intelligence (multi-trait analysis); CRC cis rs992157 0.764 rs2382827 chr2:219184387 G/A cg04880052 chr2:219191631 PNKD 0.4 6.08 0.32 3.32e-9 Colorectal cancer; CRC cis rs4713118 0.513 rs149954 chr6:28035246 G/A cg25164649 chr6:28176230 NA 0.6 8.67 0.43 2.04e-16 Parkinson's disease; CRC cis rs2836633 1.000 rs2836631 chr21:40065906 G/T cg05519781 chr21:40033154 ERG -0.53 -9.84 -0.48 3.29e-20 Coronary artery disease; CRC trans rs2727020 0.617 rs7102702 chr11:49401125 T/G cg15704280 chr7:45808275 SEPT13 -0.81 -11.42 -0.53 1.17e-25 Coronary artery disease; CRC cis rs9916302 0.861 rs2338801 chr17:37490780 G/T cg00129232 chr17:37814104 STARD3 0.56 8.25 0.41 3.76e-15 Glomerular filtration rate (creatinine); CRC cis rs61008539 0.893 rs7783487 chr7:860160 A/C cg15782153 chr7:917662 C7orf20 0.48 7.94 0.4 3.31e-14 Perceived unattractiveness to mosquitoes; CRC cis rs2228479 0.850 rs17226973 chr16:89825248 T/C cg06558623 chr16:89946397 TCF25 1.13 10.45 0.5 2.85e-22 Skin colour saturation; CRC cis rs7647973 0.600 rs13064780 chr3:49274826 T/G cg20833759 chr3:49053208 WDR6;DALRD3 0.39 6.37 0.33 6.35e-10 Menarche (age at onset); CRC cis rs9368481 0.761 rs9348746 chr6:26970357 C/G cg06675483 chr6:26987649 LOC100270746;C6orf41 -0.41 -5.74 -0.3 2.15e-8 Autism spectrum disorder or schizophrenia; CRC cis rs6565180 0.888 rs12447833 chr16:30390314 T/C cg17640201 chr16:30407289 ZNF48 0.83 13.31 0.59 1.24e-32 Tonsillectomy; CRC cis rs7224685 0.539 rs2054039 chr17:4014538 C/A cg10724054 chr17:3904396 NA -0.38 -6.1 -0.32 2.91e-9 Type 2 diabetes; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg16296880 chr4:39367793 RFC1 0.38 6.2 0.32 1.72e-9 Liver disease severity in Alagille syndrome; CRC trans rs6678914 0.966 rs12033508 chr1:202180401 A/G cg19977628 chr5:1262072 TERT 0.42 5.99 0.31 5.37e-9 Breast cancer (estrogen-receptor negative);Breast cancer; CRC cis rs12477438 0.520 rs11685759 chr2:99766217 T/C cg14399236 chr2:99771627 LIPT1;TSGA10 0.83 14.8 0.63 2.35e-38 Chronic sinus infection; CRC trans rs61931739 0.500 rs1601628 chr12:34047375 A/C cg26384229 chr12:38710491 ALG10B 0.51 6.96 0.36 1.82e-11 Morning vs. evening chronotype; CRC cis rs79057730 0.599 rs4720893 chr7:804434 G/A cg05729249 chr7:766119 PRKAR1B;HEATR2 0.7 7.16 0.37 5.26e-12 Initial pursuit acceleration; CRC cis rs9640161 0.789 rs34728606 chr7:150054694 G/A cg13722127 chr7:150037890 RARRES2 0.4 5.73 0.3 2.27e-8 Blood protein levels;Circulating chemerin levels; CRC cis rs4819052 0.765 rs2838827 chr21:46656146 C/T cg02159808 chr21:46707872 POFUT2;LOC642852 0.48 6.17 0.32 2.06e-9 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs735396 0.731 rs1182933 chr12:121454622 C/T cg02403541 chr12:121454288 C12orf43 0.52 7.59 0.39 3.34e-13 N-glycan levels; CRC cis rs67478160 0.643 rs8005594 chr14:104279889 T/C cg08213375 chr14:104286397 PPP1R13B 0.62 12.92 0.58 3.52e-31 Schizophrenia; CRC trans rs1814175 0.791 rs9787917 chr11:49937281 C/T cg11707556 chr5:10655725 ANKRD33B -0.44 -8.31 -0.42 2.52e-15 Height; CRC trans rs1814175 0.645 rs4625470 chr11:49983769 T/C cg11707556 chr5:10655725 ANKRD33B -0.52 -10.05 -0.48 6.61e-21 Height; CRC cis rs870825 0.616 rs10428373 chr4:185639002 A/T cg04058563 chr4:185651563 MLF1IP 0.73 9.56 0.47 2.93e-19 Blood protein levels; CRC cis rs4268898 0.722 rs11680491 chr2:24416292 T/A cg26838691 chr2:24397539 C2orf84 0.4 5.67 0.3 3.05e-8 Asthma; CRC trans rs951252 0.504 rs11734405 chr4:146081096 C/T cg00441754 chr19:45394894 TOMM40 0.5 6.34 0.33 7.56e-10 Hip circumference; CRC cis rs12908161 0.853 rs11633788 chr15:85305142 T/A cg11189052 chr15:85197271 WDR73 0.5 7.49 0.38 6.2800000000000005e-13 Schizophrenia; CRC cis rs6570726 0.791 rs392612 chr6:145881586 C/G cg05347473 chr6:146136440 FBXO30 -0.42 -6.29 -0.33 1.01e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs57994353 0.600 rs13295852 chr9:139308426 G/A cg14119001 chr9:139324193 INPP5E -0.43 -5.8 -0.3 1.54e-8 Eosinophil counts;Cutaneous squamous cell carcinoma; CRC cis rs17685 0.712 rs6464994 chr7:75784668 C/T cg16489192 chr7:75678113 MDH2;STYXL1 -0.36 -5.71 -0.3 2.56e-8 Coffee consumption;Coffee consumption (cups per day); CRC cis rs6580649 0.941 rs1635529 chr12:48395102 T/G cg05342945 chr12:48394962 COL2A1 -0.45 -6.22 -0.32 1.48e-9 Lung cancer; CRC cis rs1448094 0.511 rs17345272 chr12:86165334 A/C cg19622623 chr12:86230825 RASSF9 -0.38 -5.85 -0.31 1.18e-8 Major depressive disorder; CRC cis rs478304 0.934 rs610037 chr11:65546857 A/C cg27068330 chr11:65405492 SIPA1 0.45 6.74 0.35 7.31e-11 Acne (severe); CRC cis rs7107174 1.000 rs4945268 chr11:78037936 T/C cg02023728 chr11:77925099 USP35 0.48 7.27 0.37 2.71e-12 Testicular germ cell tumor; CRC cis rs2985684 0.901 rs57119148 chr14:50097226 T/C cg04989706 chr14:50066350 PPIL5 -0.5 -7.08 -0.36 8.72e-12 Carotid intima media thickness; CRC cis rs10504229 0.906 rs7006539 chr8:58178799 A/T cg02725872 chr8:58115012 NA -0.38 -6.33 -0.33 7.81e-10 Developmental language disorder (linguistic errors); CRC cis rs8060686 0.641 rs12446007 chr16:68189054 C/T cg26727032 chr16:67993705 SLC12A4 -0.55 -6.26 -0.33 1.22e-9 HDL cholesterol;Metabolic syndrome; CRC cis rs6684514 0.961 rs11264469 chr1:156276746 A/G cg16558208 chr1:156270281 VHLL 0.57 8.89 0.44 4.21e-17 Mean corpuscular hemoglobin concentration;Glycated hemoglobin levels; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg04870010 chr2:131099943 IMP4;CCDC115 0.51 6.42 0.33 4.79e-10 Thyroid stimulating hormone; CRC cis rs10479542 0.784 rs7703730 chr5:178986632 C/A cg00080972 chr5:178986291 RUFY1 -0.39 -7.57 -0.39 3.69e-13 Lung cancer; CRC cis rs7039377 0.541 rs7850196 chr9:38671574 G/T cg14625731 chr9:38672608 NA -0.36 -5.77 -0.3 1.85e-8 Obesity-related traits; CRC cis rs8072100 0.676 rs9908049 chr17:45502096 G/C cg08085267 chr17:45401833 C17orf57 -0.56 -8.45 -0.42 9.82e-16 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs7927592 0.871 rs55953412 chr11:68328283 C/T cg01657329 chr11:68192670 LRP5 -0.47 -6.73 -0.35 7.35e-11 Total body bone mineral density; CRC cis rs561341 0.769 rs8074383 chr17:30178793 C/T cg19193384 chr17:30244184 NA 0.53 5.95 0.31 6.73e-9 Hip circumference adjusted for BMI; CRC cis rs3751196 0.808 rs76281167 chr12:104220034 A/G cg02344784 chr12:104178138 NT5DC3 0.71 7.25 0.37 3.05e-12 Sense of smell; CRC cis rs9916302 0.904 rs12452509 chr17:37574722 G/A cg03013999 chr17:37608204 MED1 0.47 7.31 0.37 2e-12 Glomerular filtration rate (creatinine); CRC cis rs9914988 0.887 rs11652710 chr17:27145075 C/T cg16670446 chr17:27188758 MIR451;MIR144 0.53 8.4 0.42 1.32e-15 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs11758351 0.660 rs11759904 chr6:26231443 T/C cg10723962 chr6:26240782 HIST1H4F -0.39 -6.27 -0.33 1.15e-9 Gout;Renal underexcretion gout; CRC cis rs10791323 0.569 rs5019134 chr11:133713082 G/C cg15485101 chr11:133734466 NA 0.43 7.45 0.38 8.2e-13 Childhood ear infection; CRC cis rs4746091 0.526 rs4747176 chr10:73402498 A/G cg22763136 chr10:73395000 CDH23 0.35 5.98 0.31 5.83e-9 Selective IgA deficiency; CRC trans rs75804782 0.641 rs56396448 chr2:239335234 C/T cg01134436 chr17:81009848 B3GNTL1 0.79 7.42 0.38 9.91e-13 Morning vs. evening chronotype;Chronotype; CRC cis rs172166 0.694 rs1631552 chr6:28089699 C/A cg15845792 chr6:28175446 NA 0.8 11.91 0.55 1.99e-27 Cardiac Troponin-T levels; CRC cis rs12893668 0.703 rs2403197 chr14:104053764 C/T cg08213375 chr14:104286397 PPP1R13B 0.36 5.75 0.3 2e-8 Reticulocyte count; CRC cis rs11677416 1.000 rs1878318 chr2:113545185 A/G cg27083787 chr2:113543245 IL1A 0.44 6.07 0.32 3.43e-9 Response to antipsychotic treatment in schizophrenia (working memory); CRC cis rs9463078 0.764 rs2396370 chr6:44946472 A/G cg25276700 chr6:44698697 NA -0.28 -6.77 -0.35 6e-11 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; CRC cis rs651907 0.557 rs17411983 chr3:101399126 A/G cg03837452 chr3:101395095 ZBTB11;LOC100009676 -0.62 -8.38 -0.42 1.52e-15 Colorectal cancer; CRC cis rs713587 0.571 rs2438679 chr2:25317653 C/T cg22495460 chr2:25135724 ADCY3 0.39 5.75 0.3 2.02e-8 Body mass index in non-asthmatics; CRC cis rs8060686 0.641 rs55682260 chr16:68057880 G/A cg26727032 chr16:67993705 SLC12A4 -0.56 -6.23 -0.32 1.45e-9 HDL cholesterol;Metabolic syndrome; CRC cis rs12760731 0.565 rs12028023 chr1:178087408 G/A cg00404053 chr1:178313656 RASAL2 1.06 11.28 0.53 3.67e-25 Obesity-related traits; CRC cis rs1129187 0.934 rs9471974 chr6:42918984 T/A cg10862848 chr6:42927986 GNMT -0.37 -8.7 -0.43 1.57e-16 Alzheimer's disease in APOE e4+ carriers; CRC cis rs13088645 0.532 rs12695613 chr3:134166572 A/T cg06109529 chr3:134205091 CEP63;ANAPC13 0.49 6.53 0.34 2.43e-10 Coronary artery disease; CRC cis rs7811142 1.000 rs73161762 chr7:100014846 C/T cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.14 15.78 0.66 3.83e-42 Platelet count; CRC cis rs11785400 1.000 rs11776301 chr8:143737142 A/G cg24634471 chr8:143751801 JRK 0.53 7.53 0.38 4.9e-13 Schizophrenia; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg00373665 chr1:234735703 NA 0.51 7.25 0.37 3.05e-12 Response to antipsychotic treatment; CRC cis rs10504229 0.724 rs16922734 chr8:58111192 C/T cg04204079 chr8:58130323 NA -0.46 -5.84 -0.31 1.22e-8 Developmental language disorder (linguistic errors); CRC cis rs2933343 1.000 rs2630252 chr3:128624772 T/C cg11901034 chr3:128598214 ACAD9 -0.51 -6.2 -0.32 1.71e-9 IgG glycosylation; CRC cis rs6964587 1.000 rs10245095 chr7:91710845 A/G cg17063962 chr7:91808500 NA 0.81 14.41 0.62 8.09e-37 Breast cancer; CRC cis rs2204008 0.687 rs2320523 chr12:38251397 T/C cg26384229 chr12:38710491 ALG10B 0.66 9.19 0.45 4.44e-18 Bladder cancer; CRC cis rs826838 1.000 rs860400 chr12:39081279 A/G cg26384229 chr12:38710491 ALG10B -0.65 -10.0 -0.48 9.53e-21 Heart rate; CRC cis rs7726839 0.540 rs3792720 chr5:643028 T/G cg14541582 chr5:601475 NA -0.36 -7.23 -0.37 3.43e-12 Obesity-related traits; CRC trans rs1127311 0.901 rs11264223 chr1:154565519 G/A cg05270119 chr15:66161672 RAB11A 0.44 6.06 0.32 3.75e-9 C-reactive protein levels or triglyceride levels (pleiotropy); CRC cis rs6963495 0.649 rs1706888 chr7:105149176 A/G cg02135003 chr7:105160482 PUS7 -0.53 -8.34 -0.42 2.05e-15 Bipolar disorder (body mass index interaction); CRC cis rs12612619 0.732 rs10865461 chr2:27292651 T/C cg00617064 chr2:27272375 NA -0.38 -6.43 -0.33 4.47e-10 Venous thromboembolism adjusted for sickle cell variant rs77121243-T; CRC cis rs10504229 0.906 rs113857287 chr8:58191683 T/C cg24829409 chr8:58192753 C8orf71 -0.69 -11.17 -0.52 9.09e-25 Developmental language disorder (linguistic errors); CRC cis rs8051149 0.688 rs12444533 chr16:87869711 C/T cg01412419 chr16:87856264 NA 0.55 7.83 0.4 6.92e-14 Blood metabolite levels; CRC cis rs826838 0.585 rs12296822 chr12:38625829 A/T cg26384229 chr12:38710491 ALG10B -0.52 -7.52 -0.38 5.28e-13 Heart rate; CRC cis rs7827545 1.000 rs6992097 chr8:135565844 G/A cg17885191 chr8:135476712 NA 0.54 7.41 0.38 1.06e-12 Hypertension (SNP x SNP interaction); CRC trans rs657075 0.595 rs35719560 chr5:131584395 T/C cg24629898 chr13:20718496 GJA3 0.39 6.04 0.32 4.23e-9 Rheumatoid arthritis; CRC trans rs2727020 0.553 rs4103567 chr11:49255389 C/T cg15704280 chr7:45808275 SEPT13 -0.65 -9.95 -0.48 1.47e-20 Coronary artery disease; CRC cis rs490234 0.702 rs13284551 chr9:128411969 C/T cg14078157 chr9:128172775 NA -0.41 -6.81 -0.35 4.64e-11 Mean arterial pressure; CRC cis rs2718058 0.613 rs2718037 chr7:37777846 G/C cg24998770 chr7:37888106 TXNDC3 0.38 6.07 0.32 3.48e-9 Alzheimer's disease (late onset); CRC cis rs244731 0.959 rs918459 chr5:176669030 C/T cg17509989 chr5:176798049 RGS14 -0.6 -8.22 -0.41 4.79e-15 Urate levels in lean individuals; CRC cis rs7605378 1.000 rs2577852 chr2:200687248 C/T cg23649088 chr2:200775458 C2orf69 0.56 7.98 0.4 2.43e-14 Osteoporosis; CRC cis rs4665809 0.531 rs34081866 chr2:26475940 C/T cg27170947 chr2:26402098 FAM59B 0.62 8.31 0.42 2.62e-15 Gut microbiome composition (summer); CRC cis rs11123610 0.520 rs60644898 chr2:3718646 G/A cg25251562 chr2:3704773 ALLC -0.49 -6.12 -0.32 2.62e-9 Response to inhaled corticosteroid treatment in asthma (change in FEV1); CRC cis rs904251 0.523 rs2776872 chr6:37482787 C/G cg25019722 chr6:37503610 NA -0.46 -8.64 -0.43 2.4e-16 Cognitive performance; CRC cis rs7408868 1.000 rs7249525 chr19:15277309 G/A cg14696996 chr19:15285081 NOTCH3 0.96 9.0 0.44 1.82e-17 Pulse pressure; CRC cis rs9649213 0.531 rs35216698 chr7:97896175 C/T cg21770322 chr7:97807741 LMTK2 0.57 9.52 0.46 3.93e-19 Prostate cancer (SNP x SNP interaction); CRC cis rs7255374 0.566 rs7255904 chr19:41529020 C/T cg20630647 chr19:41531805 NA 0.37 6.56 0.34 2.12e-10 DDT metabolite (p,p'-DDE levels); CRC cis rs6456156 0.586 rs7762156 chr6:167485831 A/T cg07741184 chr6:167504864 NA 0.38 6.5 0.34 2.93e-10 Primary biliary cholangitis; CRC trans rs35110281 0.720 rs162376 chr21:44926759 G/T cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO -0.49 -8.07 -0.41 1.32e-14 Mean corpuscular volume; CRC cis rs9905704 0.918 rs581903 chr17:56719197 C/T cg12560992 chr17:57184187 TRIM37 0.56 7.63 0.39 2.5e-13 Testicular germ cell tumor; CRC cis rs2976388 0.566 rs2585141 chr8:143806343 G/A cg20041105 chr8:143859282 LYNX1 -0.44 -7.25 -0.37 2.93e-12 Urinary tract infection frequency; CRC cis rs910316 0.737 rs108622 chr14:75481908 A/G cg11812906 chr14:75593930 NEK9 -0.57 -8.6 -0.43 3.23e-16 Height; CRC cis rs7666738 0.716 rs1426660 chr4:98876792 T/A cg17366294 chr4:99064904 C4orf37 0.41 6.67 0.35 1.08e-10 Colonoscopy-negative controls vs population controls; CRC trans rs6951245 1.000 rs11763020 chr7:1060288 C/T cg13565492 chr6:43139072 SRF -0.71 -7.39 -0.38 1.21e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs4481887 0.927 rs4558008 chr1:248477641 C/T cg00666640 chr1:248458726 OR2T12 0.46 7.89 0.4 4.64e-14 Common traits (Other); CRC cis rs2952156 0.684 rs881844 chr17:37810218 C/G cg00129232 chr17:37814104 STARD3 -0.69 -12.23 -0.56 1.3e-28 Asthma; CRC cis rs910316 1.000 rs3742773 chr14:75579643 A/G cg03030879 chr14:75389066 RPS6KL1 -0.48 -7.55 -0.38 4.31e-13 Height; CRC cis rs60871478 1.000 rs62432860 chr7:807522 G/C cg05535760 chr7:792225 HEATR2 0.8 10.66 0.51 5.61e-23 Cerebrospinal P-tau181p levels; CRC trans rs2274459 0.778 rs2281917 chr6:33655728 G/C cg18356190 chr4:74964260 CXCL2 0.4 6.04 0.32 4.13e-9 Obesity (extreme); CRC trans rs2243480 1.000 rs316332 chr7:65604299 A/G cg10756647 chr7:56101905 PSPH 0.74 7.7 0.39 1.66e-13 Diabetic kidney disease; CRC cis rs1728785 1.000 rs1749793 chr16:68569312 C/T cg02972257 chr16:68554789 NA -0.62 -7.2 -0.37 4.17e-12 Ulcerative colitis; CRC cis rs7208859 0.673 rs73277978 chr17:29191449 A/G cg14008862 chr17:28927542 LRRC37B2 0.55 5.74 0.3 2.12e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs1865760 0.622 rs9968910 chr6:26072095 A/C cg17691542 chr6:26056736 HIST1H1C 0.63 8.91 0.44 3.45e-17 Height; CRC cis rs7647973 0.593 rs58339610 chr3:49845006 T/A cg03060546 chr3:49711283 APEH -0.66 -8.01 -0.4 2.03e-14 Menarche (age at onset); CRC cis rs9291683 0.588 rs13133766 chr4:10019732 C/T cg00071950 chr4:10020882 SLC2A9 0.68 13.33 0.59 1.07e-32 Bone mineral density; CRC cis rs2032447 0.736 rs115810 chr6:25975883 G/C cg12588279 chr6:26043732 HIST1H2BB 0.51 7.29 0.37 2.38e-12 Intelligence (multi-trait analysis); CRC cis rs2976388 0.609 rs2717601 chr8:143807924 T/C cg05569086 chr8:143859399 LYNX1 0.39 6.74 0.35 7.07e-11 Urinary tract infection frequency; CRC cis rs3785574 0.927 rs2854183 chr17:61968002 C/T cg06873352 chr17:61820015 STRADA 0.45 6.92 0.36 2.32e-11 Height; CRC cis rs11229555 1.000 rs3168135 chr11:58386177 G/A cg15696309 chr11:58395628 NA -0.95 -13.35 -0.59 8.41e-33 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; CRC cis rs8067545 0.750 rs7208025 chr17:19997870 T/C cg13482628 chr17:19912719 NA 0.44 7.06 0.36 1.01e-11 Schizophrenia; CRC trans rs2303319 0.504 rs12467613 chr2:162603216 G/T cg23247704 chr1:116518985 SLC22A15 -0.72 -6.14 -0.32 2.42e-9 Cognitive function; CRC cis rs2070488 0.965 rs2366119 chr3:38484453 C/T cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.9 16.79 0.68 4.11e-46 Electrocardiographic conduction measures; CRC cis rs9649213 0.593 rs56286037 chr7:98019522 C/T cg21770322 chr7:97807741 LMTK2 0.52 8.45 0.42 9.87e-16 Prostate cancer (SNP x SNP interaction); CRC cis rs9916302 0.904 rs1966916 chr17:37425238 T/G cg15445000 chr17:37608096 MED1 0.42 9.24 0.45 3.16e-18 Glomerular filtration rate (creatinine); CRC cis rs9303401 0.659 rs62081315 chr17:56781468 T/C cg10487724 chr17:56770010 TEX14;RAD51C 0.79 10.0 0.48 1.01e-20 Cognitive test performance; CRC cis rs8062405 0.964 rs11864107 chr16:28885931 T/C cg08761264 chr16:28874980 SH2B1 -0.44 -5.83 -0.31 1.33e-8 Cognitive ability (multi-trait analysis);Cognitive ability; CRC trans rs35110281 0.517 rs11089020 chr21:44939991 C/T cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.43 6.68 0.35 1e-10 Mean corpuscular volume; CRC cis rs10450586 0.932 rs10835152 chr11:27311217 T/G cg10370305 chr11:27303972 NA 0.35 5.7 0.3 2.68e-8 Total body bone mineral density; CRC cis rs769267 0.965 rs2074299 chr19:19380646 T/C cg02546618 chr19:19431379 KIAA0892;SF4 0.46 6.29 0.33 9.83e-10 Tonsillectomy; CRC cis rs9527 0.590 rs7087040 chr10:104799668 G/A cg04362960 chr10:104952993 NT5C2 0.59 8.32 0.42 2.33e-15 Arsenic metabolism; CRC cis rs769267 0.930 rs2304098 chr19:19646272 T/C cg03709012 chr19:19516395 GATAD2A 0.72 11.11 0.52 1.5e-24 Tonsillectomy; CRC cis rs4713118 0.824 rs2179095 chr6:27750858 A/G cg21251018 chr6:28226885 NKAPL -0.42 -5.97 -0.31 6.12e-9 Parkinson's disease; CRC cis rs2404602 0.647 rs11072612 chr15:76960984 A/T cg23625390 chr15:77176239 SCAPER -0.87 -13.96 -0.61 4.02e-35 Blood metabolite levels; CRC cis rs9486715 0.830 rs2255552 chr6:96999643 A/G cg18709589 chr6:96969512 KIAA0776 -0.39 -5.62 -0.3 3.99e-8 Headache; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg11450715 chr2:171627404 NA -0.38 -5.98 -0.31 5.86e-9 Myopia (pathological); CRC cis rs1552244 1.000 rs9849434 chr3:10133710 A/G cg08888203 chr3:10149979 C3orf24 -0.69 -9.88 -0.48 2.4e-20 Alzheimer's disease; CRC cis rs2857891 0.862 rs957747 chr11:6966814 A/G cg04053776 chr11:6947353 ZNF215 0.42 5.87 0.31 1.06e-8 Response to cytadine analogues (cytosine arabinoside); CRC cis rs1580019 0.568 rs2122633 chr7:32523870 G/T cg07520158 chr7:32535189 LSM5;AVL9 0.54 7.81 0.4 7.8e-14 Cognitive ability; CRC cis rs9747347 1 rs9747347 chr17:79606820 T/C cg02117656 chr17:79614917 TSPAN10 0.44 6.93 0.36 2.22e-11 Myopia; CRC trans rs13046373 0.905 rs4816372 chr21:32077414 A/T cg27216355 chr16:71599010 NA -0.4 -5.98 -0.31 5.74e-9 HDL cholesterol; CRC cis rs8067545 0.616 rs203470 chr17:19858626 C/T cg04132472 chr17:19861366 AKAP10 0.43 6.56 0.34 2.14e-10 Schizophrenia; CRC cis rs911555 0.713 rs10162425 chr14:103931621 C/T cg24130564 chr14:104152367 KLC1 -0.41 -5.72 -0.3 2.43e-8 Intelligence (multi-trait analysis); CRC cis rs10752881 1.000 rs10797800 chr1:182969828 C/A ch.1.3577855R chr1:183094577 LAMC1 0.86 15.01 0.64 3.66e-39 Colorectal cancer; CRC cis rs6684514 1.000 rs11264464 chr1:156250887 T/G cg16558208 chr1:156270281 VHLL 0.58 9.08 0.45 1.03e-17 Mean corpuscular hemoglobin concentration;Glycated hemoglobin levels; CRC cis rs6951245 0.572 rs73264028 chr7:1045455 G/A cg26224354 chr7:1096374 C7orf50;GPR146 -0.81 -7.59 -0.39 3.38e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs1005277 0.522 rs289645 chr10:37943642 T/C cg00409905 chr10:38381863 ZNF37A -0.57 -9.05 -0.45 1.29e-17 Extrinsic epigenetic age acceleration; CRC cis rs2153535 0.580 rs6912374 chr6:8456423 T/C cg07606381 chr6:8435919 SLC35B3 0.68 11.06 0.52 2.24e-24 Motion sickness; CRC cis rs7618915 0.547 rs33967311 chr3:52683864 G/T cg18099408 chr3:52552593 STAB1 -0.43 -6.96 -0.36 1.8e-11 Bipolar disorder; CRC cis rs4731207 0.596 rs723444 chr7:124659224 G/A cg23710748 chr7:124431027 NA -0.39 -6.04 -0.32 4.26e-9 Cutaneous malignant melanoma; CRC cis rs2204008 0.806 rs7305409 chr12:38349133 G/A cg13010199 chr12:38710504 ALG10B 0.45 5.76 0.3 1.96e-8 Bladder cancer; CRC cis rs3849570 0.643 rs1851928 chr3:81975395 C/T cg07356753 chr3:81810745 GBE1 -0.48 -6.5 -0.34 3.06e-10 Waist circumference;Body mass index; CRC cis rs9649213 0.537 rs35997266 chr7:97965566 T/C cg24562669 chr7:97807699 LMTK2 0.44 7.38 0.38 1.32e-12 Prostate cancer (SNP x SNP interaction); CRC trans rs2303319 0.504 rs58622044 chr2:162596287 A/G cg13034943 chr12:132379564 ULK1 -0.69 -5.96 -0.31 6.33e-9 Cognitive function; CRC cis rs60871478 0.636 rs12534606 chr7:895928 A/G cg13844804 chr7:814759 HEATR2 -0.54 -5.76 -0.3 1.94e-8 Cerebrospinal P-tau181p levels; CRC cis rs11690935 0.959 rs12692973 chr2:172642057 A/G cg13550731 chr2:172543902 DYNC1I2 1.07 18.21 0.71 9.6e-52 Schizophrenia; CRC cis rs16975963 0.644 rs12151280 chr19:38067890 A/C cg15135657 chr19:38346511 NA -0.44 -6.25 -0.33 1.26e-9 Longevity; CRC cis rs6951245 1.000 rs6951245 chr7:1058193 G/A cg07217954 chr7:1067459 C7orf50 0.57 5.9 0.31 9.2e-9 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs524281 0.861 rs535395 chr11:65906534 A/G cg14036092 chr11:66035641 RAB1B 0.48 6.08 0.32 3.42e-9 Electroencephalogram traits; CRC cis rs77972916 0.611 rs61552842 chr2:43584036 G/T cg06169590 chr2:43455088 ZFP36L2;LOC100129726 -0.51 -5.94 -0.31 7.24e-9 Granulocyte percentage of myeloid white cells; CRC cis rs651907 0.557 rs11711079 chr3:101386918 G/A cg12386194 chr3:101231763 SENP7 0.49 7.11 0.36 7.34e-12 Colorectal cancer; CRC cis rs614226 0.935 rs7137953 chr12:120894685 C/T cg27489772 chr12:121021490 NA -0.49 -6.67 -0.35 1.07e-10 Type 1 diabetes nephropathy; CRC cis rs2228479 0.850 rs17233664 chr16:89810628 C/T cg19635926 chr16:89946313 TCF25 0.66 5.98 0.31 5.71e-9 Skin colour saturation; CRC trans rs944990 0.595 rs10123378 chr9:96375217 C/T cg16357719 chr16:2317538 RNPS1 0.45 7.1 0.36 7.84e-12 Body mass index; CRC cis rs4862750 0.914 rs6553026 chr4:187875648 C/T cg03647317 chr4:187891568 NA -0.54 -9.97 -0.48 1.2e-20 Lobe attachment (rater-scored or self-reported); CRC cis rs7605827 0.930 rs11893272 chr2:15613796 C/T cg19274914 chr2:15703543 NA 0.39 5.95 0.31 6.89e-9 Educational attainment (years of education); CRC cis rs6951245 1.000 rs1997243 chr7:1083777 A/G cg24642844 chr7:1081250 C7orf50 -0.78 -9.34 -0.46 1.44e-18 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs6484504 0.600 rs2616815 chr11:31327316 C/T cg14844989 chr11:31128820 NA 0.36 6.42 0.33 4.69e-10 Red blood cell count; CRC cis rs7666738 0.791 rs10013680 chr4:99023030 G/C cg05340658 chr4:99064831 C4orf37 0.58 8.61 0.43 3.14e-16 Colonoscopy-negative controls vs population controls; CRC trans rs2303319 0.504 rs62189054 chr2:162624654 C/G cg22627826 chr19:1240265 ATP5D -0.72 -6.24 -0.33 1.37e-9 Cognitive function; CRC cis rs17067123 0.614 rs11727059 chr4:180065225 G/A cg26610307 chr4:180072759 NA -0.56 -6.74 -0.35 7.28e-11 Response to hepatitis C treatment; CRC cis rs9875589 0.509 rs4685061 chr3:14043823 G/A cg14375111 chr3:14165186 TMEM43;CHCHD4 0.41 6.3 0.33 9.81e-10 Ovarian reserve; CRC cis rs4975709 0.589 rs931508 chr5:1861224 C/G cg11168104 chr5:1857477 NA -0.39 -6.8 -0.35 4.96e-11 Cardiovascular disease risk factors; CRC cis rs9399137 0.507 rs13197750 chr6:135312380 G/A cg22676075 chr6:135203613 NA 0.59 9.01 0.45 1.66e-17 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; CRC cis rs3823572 0.511 rs2971982 chr7:133657698 C/T cg03336402 chr7:133662267 EXOC4 -0.67 -10.62 -0.51 7.59e-23 Intelligence (multi-trait analysis); CRC cis rs7666738 0.830 rs13125432 chr4:98961253 G/A cg05340658 chr4:99064831 C4orf37 0.61 9.45 0.46 6.55e-19 Colonoscopy-negative controls vs population controls; CRC cis rs6502050 0.871 rs8066970 chr17:80076051 T/C cg09264619 chr17:80180166 NA 0.38 6.28 0.33 1.08e-9 Life satisfaction; CRC cis rs736408 0.521 rs13074853 chr3:52779801 T/C cg10802521 chr3:52805072 NEK4 -0.57 -8.87 -0.44 4.63e-17 Bipolar disorder; CRC cis rs11252926 0.673 rs10795161 chr10:497748 G/T cg18196295 chr10:418757 DIP2C 0.5 7.63 0.39 2.49e-13 Psychosis in Alzheimer's disease; CRC cis rs7618915 0.547 rs13085331 chr3:52627486 G/C cg15147215 chr3:52552868 STAB1 -0.62 -10.17 -0.49 2.64e-21 Bipolar disorder; CRC cis rs7552404 1.000 rs1498312 chr1:76177849 C/T cg22875332 chr1:76189707 ACADM 0.69 9.33 0.46 1.63e-18 Blood metabolite levels;Acylcarnitine levels; CRC cis rs289828 0.868 rs6747782 chr2:152138115 A/G cg06191203 chr2:152266755 RIF1 -0.4 -5.76 -0.3 1.96e-8 Blood protein levels; CRC cis rs12762955 0.519 rs10795306 chr10:1019138 A/T cg26597838 chr10:835615 NA -0.43 -5.81 -0.31 1.44e-8 Response to angiotensin II receptor blocker therapy; CRC cis rs2075371 1.000 rs2598288 chr7:133977304 A/T cg02659138 chr7:134003124 SLC35B4 0.36 6.19 0.32 1.77e-9 Mean platelet volume; CRC cis rs35110281 0.627 rs7283362 chr21:44973667 C/G cg04455712 chr21:45112962 RRP1B 0.35 6.72 0.35 8.02e-11 Mean corpuscular volume; CRC cis rs7071206 0.947 rs4979905 chr10:79416367 C/T cg07817648 chr10:79422355 NA -0.73 -9.53 -0.47 3.57e-19 Bone mineral density; CRC cis rs2115630 0.905 rs6496401 chr15:85297793 A/T cg09876464 chr15:85330779 ZNF592 0.44 7.36 0.38 1.46e-12 P wave terminal force; CRC cis rs477895 1.000 rs7947143 chr11:64090422 G/A cg19465662 chr11:63993652 NUDT22;TRPT1 0.65 6.25 0.33 1.25e-9 Mean platelet volume; CRC cis rs4555082 0.834 rs2735817 chr14:105717796 A/G cg18132624 chr14:105716052 BTBD6;BRF1 0.52 8.8 0.44 7.78e-17 Mean platelet volume;Platelet distribution width; CRC cis rs17641971 0.684 rs4873093 chr8:49974740 G/T cg00325661 chr8:49890786 NA 0.37 6.51 0.34 2.89e-10 Blood metabolite levels; CRC cis rs780096 0.526 rs704791 chr2:27657167 T/C cg12000995 chr2:27665139 KRTCAP3 -0.32 -6.75 -0.35 6.69e-11 Total body bone mineral density; CRC cis rs739401 0.572 rs410820 chr11:3080102 G/A cg25174290 chr11:3078921 CARS 0.52 7.92 0.4 3.74e-14 Longevity; CRC cis rs6543140 0.964 rs1523205 chr2:103070176 G/T cg03938978 chr2:103052716 IL18RAP 0.41 6.55 0.34 2.21e-10 Blood protein levels; CRC cis rs17209837 0.607 rs4148816 chr7:87087731 G/A cg00919237 chr7:87102261 ABCB4 -0.54 -7.14 -0.37 6.18e-12 Gallbladder cancer; CRC cis rs2882667 0.654 rs10044432 chr5:138274896 C/T cg09476006 chr5:138032270 NA 0.57 9.22 0.45 3.72e-18 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs7809950 0.822 rs2712228 chr7:107300340 A/C cg23024343 chr7:107201750 COG5 0.46 6.57 0.34 1.98e-10 Coronary artery disease; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg08399230 chr16:4665037 FAM100A 0.35 6.38 0.33 6.04e-10 Liver disease severity in Alagille syndrome; CRC cis rs9467773 1.000 rs28558133 chr6:26531433 G/C cg09904177 chr6:26538194 HMGN4 0.86 14.9 0.63 9.92e-39 Intelligence (multi-trait analysis); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg12459316 chr3:101292891 PCNP 0.39 5.97 0.31 6.12e-9 Liver disease severity in Alagille syndrome; CRC cis rs62229266 0.659 rs2835258 chr21:37424365 G/A cg08632701 chr21:37451849 NA -0.42 -6.48 -0.34 3.43e-10 Mitral valve prolapse; CRC cis rs4853036 0.904 rs12713683 chr2:70156321 G/A cg02498382 chr2:70120550 SNRNP27 -0.45 -6.79 -0.35 5.39e-11 Colorectal or endometrial cancer; CRC cis rs6582630 0.574 rs12146797 chr12:38436499 T/C cg26384229 chr12:38710491 ALG10B 0.7 9.8 0.48 4.54e-20 Drug-induced liver injury (flucloxacillin); CRC cis rs12594515 1.000 rs6493169 chr15:45986994 A/G cg06207120 chr15:45996521 NA -0.32 -7.9 -0.4 4.33e-14 Waist circumference;Weight; CRC cis rs7312774 0.748 rs12320535 chr12:107295813 T/C cg16260113 chr12:107380972 MTERFD3 0.75 7.63 0.39 2.48e-13 Severe influenza A (H1N1) infection; CRC cis rs2836974 0.897 rs7280375 chr21:40552408 C/T cg17971929 chr21:40555470 PSMG1 -0.8 -11.53 -0.54 4.5e-26 Cognitive function; CRC cis rs12190007 0.508 rs6605537 chr6:169730781 G/A cg16388071 chr6:169726476 NA 0.44 6.8 0.35 5.09e-11 Obesity-related traits; CRC cis rs13064411 0.518 rs6769604 chr3:113185064 A/G cg18753928 chr3:113234510 CCDC52 -0.48 -7.62 -0.39 2.79e-13 Response to simvastatin treatment (PCSK9 protein level change); CRC cis rs11098499 0.955 rs1551 chr4:120158500 T/G cg09307838 chr4:120376055 NA 0.62 9.62 0.47 1.88e-19 Corneal astigmatism; CRC cis rs2281845 0.533 rs10753891 chr1:201100482 A/G cg22815214 chr1:201083145 CACNA1S 0.5 7.07 0.36 9.41e-12 Permanent tooth development; CRC cis rs11785400 0.793 rs4336593 chr8:143739647 A/C cg10596483 chr8:143751796 JRK -0.42 -5.66 -0.3 3.22e-8 Schizophrenia; CRC cis rs4423214 0.840 rs1629220 chr11:71174553 C/T cg05163923 chr11:71159392 DHCR7 -0.64 -7.64 -0.39 2.32e-13 Vitamin D levels; CRC cis rs9611565 0.649 rs139540 chr22:42178040 C/T cg03806693 chr22:41940476 POLR3H -0.69 -9.36 -0.46 1.25e-18 Vitiligo; CRC cis rs1552244 0.572 rs67439440 chr3:10169503 C/T cg00166722 chr3:10149974 C3orf24 0.66 7.71 0.39 1.49e-13 Alzheimer's disease; CRC cis rs4713118 0.539 rs510987 chr6:27847517 G/A cg12172441 chr6:28176163 NA 0.5 6.59 0.34 1.73e-10 Parkinson's disease; CRC cis rs11723261 0.582 rs7679573 chr4:151605 G/C cg12746427 chr4:53362 ZNF718;ZNF595 0.51 7.0 0.36 1.41e-11 Immune response to smallpox vaccine (IL-6); CRC cis rs2457480 0.516 rs10899994 chr10:44656695 A/G cg09554077 chr10:44749378 NA 0.44 5.64 0.3 3.62e-8 Coronary artery disease; CRC cis rs72615157 0.634 rs79986079 chr7:99802044 C/T cg16268157 chr7:99778414 STAG3 -0.43 -5.72 -0.3 2.45e-8 Lung function (FEV1/FVC); CRC cis rs2075371 1.000 rs2544221 chr7:133993014 G/C cg20476274 chr7:133979776 SLC35B4 0.78 13.81 0.61 1.62e-34 Mean platelet volume; CRC cis rs6952407 1 rs6952407 chr7:66045512 A/G cg18876405 chr7:65276391 NA -0.62 -10.91 -0.52 7.22e-24 Cotinine glucuronidation; CRC trans rs7937682 0.883 rs553632 chr11:111462897 C/T cg18187862 chr3:45730750 SACM1L 0.43 6.14 0.32 2.38e-9 Primary sclerosing cholangitis; CRC cis rs992157 0.798 rs4674284 chr2:219161241 C/T cg00012203 chr2:219082015 ARPC2 -0.49 -7.29 -0.37 2.28e-12 Colorectal cancer; CRC cis rs6570726 0.577 rs399502 chr6:145805874 A/G cg13319975 chr6:146136371 FBXO30 -0.61 -9.0 -0.44 1.88e-17 Lobe attachment (rater-scored or self-reported); CRC cis rs28655083 0.509 rs285024 chr16:77099844 G/A cg01753188 chr16:77233325 SYCE1L;MON1B 0.48 6.74 0.35 7.27e-11 Lobe attachment (rater-scored or self-reported); CRC cis rs4713118 0.628 rs9295740 chr6:27689502 G/A cg20933634 chr6:27740509 NA 0.54 6.98 0.36 1.63e-11 Parkinson's disease; CRC cis rs847851 0.612 rs7768189 chr6:34742450 A/G cg07306190 chr6:34760872 UHRF1BP1 -0.35 -6.24 -0.33 1.36e-9 Colonoscopy-negative controls vs population controls; CRC cis rs1153858 1.000 rs7169587 chr15:45640379 A/G cg14582100 chr15:45693742 SPATA5L1 0.29 6.02 0.32 4.62e-9 Homoarginine levels; CRC cis rs8180040 1.000 rs295428 chr3:47359262 G/T cg02527881 chr3:46936655 PTH1R -0.39 -7.55 -0.38 4.19e-13 Colorectal cancer; CRC trans rs75828804 0.826 rs277506 chr16:77544440 C/T cg19423196 chr10:82049429 MAT1A 0.5 6.05 0.32 4.02e-9 Intraocular pressure; CRC cis rs6570726 0.818 rs437147 chr6:145875423 A/T cg05347473 chr6:146136440 FBXO30 0.4 6.0 0.31 5.17e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs1448094 0.511 rs10779210 chr12:86162432 T/C cg02569458 chr12:86230093 RASSF9 -0.46 -7.89 -0.4 4.53e-14 Major depressive disorder; CRC cis rs62229266 0.659 rs62230814 chr21:37403546 G/A cg08632701 chr21:37451849 NA -0.39 -6.18 -0.32 1.89e-9 Mitral valve prolapse; CRC cis rs853679 1.000 rs6905391 chr6:28262686 G/A cg15845792 chr6:28175446 NA 0.58 5.88 0.31 1e-8 Depression; CRC trans rs3780486 0.846 rs10813948 chr9:33121570 G/A cg04842962 chr6:43655489 MRPS18A 1.13 24.49 0.8 4.1e-76 IgG glycosylation; CRC cis rs7727544 0.735 rs272842 chr5:131656517 A/G cg12564285 chr5:131593104 PDLIM4 0.31 5.6 0.3 4.45e-8 Blood metabolite levels; CRC cis rs2836974 0.836 rs1041440 chr21:40627325 C/T cg06238570 chr21:40685208 BRWD1 0.79 10.91 0.52 7.57e-24 Cognitive function; CRC cis rs7626444 0.625 rs2686595 chr3:196475142 G/C cg12930392 chr3:196481615 PAK2 0.41 7.3 0.37 2.23e-12 Monocyte count; CRC trans rs561341 1.000 rs111454793 chr17:30319267 T/C cg20587970 chr11:113659929 NA -1.43 -20.38 -0.75 2.82e-60 Hip circumference adjusted for BMI; CRC cis rs736408 0.522 rs11716747 chr3:52748857 C/T cg08222913 chr3:52553049 STAB1 -0.33 -6.12 -0.32 2.64e-9 Bipolar disorder; CRC cis rs11785400 0.793 rs4567014 chr8:143737690 G/C cg24634471 chr8:143751801 JRK 0.48 6.51 0.34 2.76e-10 Schizophrenia; CRC cis rs9463078 0.665 rs9367214 chr6:45025912 G/A cg25276700 chr6:44698697 NA -0.24 -5.77 -0.3 1.81e-8 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; CRC cis rs3749237 0.615 rs55957735 chr3:49438158 G/A cg02487422 chr3:49467188 NICN1 0.42 6.89 0.35 2.9100000000000002e-11 Resting heart rate; CRC cis rs3126085 0.935 rs7540844 chr1:152230586 A/T cg09127314 chr1:152161683 NA 0.47 5.99 0.31 5.61e-9 Atopic dermatitis; CRC cis rs10504229 0.683 rs7822631 chr8:58130916 C/G cg02290350 chr8:58132656 NA -0.58 -8.16 -0.41 7.29e-15 Developmental language disorder (linguistic errors); CRC cis rs3617 0.625 rs6445541 chr3:52880128 G/T cg15147215 chr3:52552868 STAB1 -0.47 -7.63 -0.39 2.61e-13 Red blood cell count;Autism spectrum disorder or schizophrenia; CRC cis rs2160860 0.773 rs7832080 chr8:39799757 T/C cg11363097 chr8:39792086 IDO2 -0.45 -7.65 -0.39 2.28e-13 Blood metabolite levels; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg23127064 chr11:842615 TSPAN4;POLR2L 0.38 6.17 0.32 2e-9 Liver disease severity in Alagille syndrome; CRC cis rs6502050 0.799 rs12603050 chr17:80104631 A/G cg22110888 chr17:80059540 CCDC57 0.4 6.44 0.33 4.17e-10 Life satisfaction; CRC trans rs10983614 1.000 rs7867776 chr9:120072627 A/G cg23235460 chr3:187871625 LPP 0.47 6.33 0.33 8.03e-10 Survival in pancreatic cancer; CRC cis rs13256369 0.802 rs12680019 chr8:8561698 A/G cg06671706 chr8:8559999 CLDN23 0.62 9.09 0.45 9.32e-18 Obesity-related traits; CRC cis rs35883536 0.647 rs10875313 chr1:101043057 T/C cg06223162 chr1:101003688 GPR88 -0.36 -6.61 -0.34 1.56e-10 Monocyte count; CRC cis rs10504229 1.000 rs116995796 chr8:58181960 G/A cg05313129 chr8:58192883 C8orf71 -0.47 -6.99 -0.36 1.5e-11 Developmental language disorder (linguistic errors); CRC cis rs66887589 0.967 rs59516282 chr4:120502016 G/A cg09307838 chr4:120376055 NA -0.51 -7.73 -0.39 1.32e-13 Diastolic blood pressure; CRC cis rs3857067 0.806 rs11943926 chr4:95136512 G/A cg11021082 chr4:95130006 SMARCAD1 -0.53 -8.39 -0.42 1.49e-15 QT interval; CRC cis rs9527 0.571 rs7096249 chr10:104618524 G/A cg15744005 chr10:104629667 AS3MT -0.37 -7.59 -0.39 3.24e-13 Arsenic metabolism; CRC cis rs9457247 1.000 rs402749 chr6:167386104 C/T cg23791538 chr6:167370224 RNASET2 -0.38 -5.97 -0.31 6.08e-9 Crohn's disease; CRC cis rs909002 1.000 rs2292993 chr1:32140733 C/T cg13919466 chr1:32135498 COL16A1 -0.4 -7.69 -0.39 1.71e-13 Intelligence (multi-trait analysis); CRC cis rs11229555 0.645 rs12797488 chr11:58174653 A/T cg15696309 chr11:58395628 NA -0.89 -11.35 -0.53 2.09e-25 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; CRC cis rs806215 0.666 rs12672945 chr7:127510489 A/G cg25922125 chr7:127225783 GCC1 -0.49 -5.97 -0.31 6.14e-9 Type 2 diabetes; CRC trans rs7829975 0.688 rs7817376 chr8:8380530 C/T cg16141378 chr3:129829833 LOC729375 0.49 7.57 0.39 3.72e-13 Mood instability; CRC cis rs11146838 1 rs11146838 chr10:39149977 A/T cg25427524 chr10:38739819 LOC399744 -0.82 -15.21 -0.64 6.17e-40 Breast cancer; CRC cis rs9322193 0.923 rs9371486 chr6:150153226 T/C cg05861140 chr6:150128134 PCMT1 -0.4 -6.13 -0.32 2.49e-9 Lung cancer; CRC cis rs644799 1.000 rs518919 chr11:95623313 G/C cg25478527 chr11:95522999 CEP57;FAM76B 0.5 7.44 0.38 8.75e-13 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs79976124 0.879 rs17432710 chr6:66621744 T/C cg07460842 chr6:66804631 NA 0.77 9.33 0.46 1.62e-18 Type 2 diabetes; CRC cis rs17767392 0.626 rs11158898 chr14:71685205 T/A cg13720639 chr14:72061746 SIPA1L1 -0.51 -6.81 -0.35 4.66e-11 Mitral valve prolapse; CRC cis rs4664308 1.000 rs10929965 chr2:160906931 C/T cg03641300 chr2:160917029 PLA2R1 0.76 13.06 0.58 1.06e-31 Idiopathic membranous nephropathy; CRC cis rs244731 1.000 rs244730 chr5:176539212 A/G cg05207973 chr5:176823642 SLC34A1 -0.39 -5.9 -0.31 9.17e-9 Urate levels in lean individuals; CRC cis rs801193 1.000 rs4279493 chr7:66226620 C/T cg11764359 chr7:65958608 NA 0.53 8.14 0.41 8.27e-15 Aortic root size; CRC cis rs7927771 0.864 rs2053979 chr11:47439444 A/G cg18512352 chr11:47633146 NA -0.4 -7.78 -0.39 9.39e-14 Subjective well-being; CRC cis rs4665809 0.567 rs6711402 chr2:26430983 A/G cg08067268 chr2:26466485 HADHB;HADHA -0.63 -7.5 -0.38 5.98e-13 Gut microbiome composition (summer); CRC cis rs698833 0.828 rs1067341 chr2:44623687 G/A cg04920474 chr2:44395004 PPM1B 0.41 6.22 0.32 1.52e-9 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; CRC cis rs2692947 0.800 rs61409777 chr2:96581373 C/A cg22654517 chr2:96458247 NA 0.32 5.75 0.3 2.06e-8 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; CRC cis rs12580194 0.593 rs55898514 chr12:55736238 G/A cg19537932 chr12:55886519 OR6C68 -0.64 -8.33 -0.42 2.19e-15 Cancer; CRC cis rs1448094 0.838 rs28509446 chr12:86312584 A/C cg18827107 chr12:86230957 RASSF9 -0.41 -6.73 -0.35 7.76e-11 Major depressive disorder; CRC cis rs11098499 0.754 rs12506487 chr4:120271361 T/G cg24375607 chr4:120327624 NA 0.45 7.28 0.37 2.53e-12 Corneal astigmatism; CRC cis rs6732160 0.588 rs3891890 chr2:73378049 A/G cg01422370 chr2:73384389 NA 0.37 5.78 0.3 1.72e-8 Intelligence (multi-trait analysis); CRC cis rs2971970 0.519 rs2346270 chr7:133647033 G/A cg03336402 chr7:133662267 EXOC4 -0.66 -10.29 -0.49 1e-21 Intelligence (multi-trait analysis); CRC trans rs7615952 0.546 rs2979350 chr3:125362215 T/C cg02560186 chr11:3602584 NA -0.56 -7.1 -0.36 7.58e-12 Blood pressure (smoking interaction); CRC cis rs72781680 0.611 rs72783605 chr2:24287864 A/G cg20701182 chr2:24300061 SF3B14 0.62 7.33 0.37 1.78e-12 Lymphocyte counts; CRC cis rs7927771 1.000 rs12787330 chr11:47812311 C/T cg18512352 chr11:47633146 NA -0.48 -9.4 -0.46 9.71e-19 Subjective well-being; CRC cis rs4862750 0.872 rs7658314 chr4:187900356 T/C cg10295955 chr4:187884368 NA -1.06 -28.72 -0.85 1.21e-91 Lobe attachment (rater-scored or self-reported); CRC cis rs7264396 0.887 rs224347 chr20:34037523 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.43 -7.0 -0.36 1.47e-11 Total cholesterol levels; CRC cis rs11098499 0.913 rs67073020 chr4:120152557 C/T cg09307838 chr4:120376055 NA 0.59 8.55 0.43 4.8e-16 Corneal astigmatism; CRC cis rs2836974 0.931 rs2836972 chr21:40652142 G/A cg11644478 chr21:40555479 PSMG1 0.81 12.32 0.56 6.05e-29 Cognitive function; CRC cis rs6460942 0.556 rs2287067 chr7:12370533 T/C cg20607287 chr7:12443886 VWDE -0.49 -6.72 -0.35 7.96e-11 Coronary artery disease; CRC cis rs9322193 0.962 rs9689269 chr6:150112997 G/A cg05861140 chr6:150128134 PCMT1 -0.43 -7.05 -0.36 1.03e-11 Lung cancer; CRC cis rs7647973 0.925 rs11130183 chr3:49228946 A/G cg07636037 chr3:49044803 WDR6 0.64 7.89 0.4 4.38e-14 Menarche (age at onset); CRC cis rs12474201 0.775 rs7584870 chr2:46973400 A/T cg06386533 chr2:46925753 SOCS5 0.75 12.81 0.58 9.74e-31 Height; CRC cis rs1150668 0.835 rs1233696 chr6:28143010 T/C cg15786705 chr6:28176104 NA 0.48 7.18 0.37 4.74e-12 Pubertal anthropometrics; CRC trans rs2228479 0.850 rs11648689 chr16:89806732 G/A cg21302420 chr1:112162376 RAP1A 0.72 5.96 0.31 6.38e-9 Skin colour saturation; CRC cis rs4711336 1.000 rs2229642 chr6:33659472 C/G cg14003231 chr6:33640908 ITPR3 0.46 7.36 0.38 1.5e-12 Height; CRC cis rs9486719 1.000 rs3906199 chr6:97049899 C/A cg06623918 chr6:96969491 KIAA0776 -0.81 -9.54 -0.47 3.27e-19 Migraine;Coronary artery disease; CRC cis rs7617773 0.674 rs13069029 chr3:48355024 A/G cg11946769 chr3:48343235 NME6 0.73 9.79 0.47 4.96e-20 Coronary artery disease; CRC cis rs2404602 0.647 rs11852395 chr15:77087785 T/C cg23625390 chr15:77176239 SCAPER -0.85 -12.93 -0.58 3.43e-31 Blood metabolite levels; CRC trans rs11039798 0.588 rs59777067 chr11:49015350 C/T cg03929089 chr4:120376271 NA 0.64 6.42 0.33 4.71e-10 Axial length; CRC trans rs61931739 0.500 rs11053243 chr12:34514155 T/C cg26384229 chr12:38710491 ALG10B 0.62 9.17 0.45 5.2e-18 Morning vs. evening chronotype; CRC cis rs2749592 0.513 rs1208708 chr10:38085576 A/G cg00409905 chr10:38381863 ZNF37A -0.56 -8.87 -0.44 4.58e-17 Age-related hearing impairment (SNP x SNP interaction); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg24441022 chr1:154946677 SHC1;CKS1B 0.49 7.1 0.36 7.78e-12 Response to antipsychotic treatment; CRC cis rs853679 0.517 rs868987 chr6:28110148 A/G cg18032046 chr6:28092343 ZSCAN16 0.52 6.23 0.32 1.46e-9 Depression; CRC cis rs801193 0.548 rs7805152 chr7:66209253 C/T cg12463550 chr7:65579703 CRCP 0.45 6.05 0.32 3.89e-9 Aortic root size; CRC cis rs12887734 0.546 rs12885509 chr14:104273325 T/C cg08213375 chr14:104286397 PPP1R13B 0.5 8.53 0.43 5.31e-16 Schizophrenia;Autism spectrum disorder or schizophrenia; CRC cis rs6496667 0.865 rs62019277 chr15:90880438 C/T cg04176472 chr15:90893244 GABARAPL3 0.58 6.61 0.34 1.58e-10 Rheumatoid arthritis; CRC cis rs7809950 0.817 rs4727679 chr7:107085018 T/C cg23024343 chr7:107201750 COG5 -0.73 -10.08 -0.49 5.37e-21 Coronary artery disease; CRC cis rs834811 0.831 rs1097147 chr7:135880446 C/T cg01726295 chr7:135938950 NA 0.46 7.82 0.4 7.13e-14 Post-traumatic stress disorder; CRC cis rs6860806 0.507 rs169256 chr5:131688533 A/G cg18758796 chr5:131593413 PDLIM4 0.41 5.88 0.31 1.03e-8 Breast cancer; CRC cis rs4713118 0.662 rs149946 chr6:27970031 A/C cg23161317 chr6:28129485 ZNF389 -0.45 -6.21 -0.32 1.56e-9 Parkinson's disease; CRC cis rs9463078 0.585 rs718112 chr6:44859451 T/G cg25276700 chr6:44698697 NA 0.25 6.03 0.32 4.29e-9 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; CRC cis rs4727027 0.933 rs12154382 chr7:148862284 C/T cg23583168 chr7:148888333 NA -0.92 -16.26 -0.67 4.73e-44 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC cis rs9649213 0.593 rs6968144 chr7:97915697 G/A cg24562669 chr7:97807699 LMTK2 0.46 7.82 0.4 7.01e-14 Prostate cancer (SNP x SNP interaction); CRC cis rs7677751 0.806 rs67432867 chr4:55104454 A/T cg17187183 chr4:55093834 PDGFRA 0.51 7.49 0.38 6.2800000000000005e-13 Corneal astigmatism; CRC cis rs3806843 0.735 rs2563333 chr5:140052271 A/G cg19875535 chr5:140030758 IK -0.55 -8.84 -0.44 5.86e-17 Depressive symptoms (multi-trait analysis); CRC trans rs208520 0.526 rs6913344 chr6:66754285 A/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.09 -20.51 -0.75 8.7e-61 Exhaled nitric oxide output; CRC cis rs422249 0.512 rs174578 chr11:61605499 T/A cg00603274 chr11:61596626 FADS2 -0.43 -6.45 -0.34 4e-10 Trans fatty acid levels; CRC cis rs3768617 0.510 rs35968946 chr1:183114871 G/A ch.1.3577855R chr1:183094577 LAMC1 0.83 14.64 0.63 1.01e-37 Fuchs's corneal dystrophy; CRC cis rs1008375 0.931 rs6831211 chr4:17697009 G/A cg16339924 chr4:17578868 LAP3 0.47 6.24 0.33 1.37e-9 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs9733 0.596 rs34140753 chr1:150642583 T/C cg15448220 chr1:150897856 SETDB1 0.45 6.43 0.33 4.42e-10 Tonsillectomy; CRC cis rs950169 1.000 rs11638394 chr15:84778928 G/A cg24253500 chr15:84953950 NA 0.38 6.48 0.34 3.43e-10 Schizophrenia; CRC cis rs13256369 0.802 rs4840350 chr8:8561442 A/G cg06671706 chr8:8559999 CLDN23 0.61 9.04 0.45 1.35e-17 Obesity-related traits; CRC cis rs6696846 0.765 rs61822568 chr1:205081166 C/G cg03948781 chr1:205179583 DSTYK 0.4 5.63 0.3 3.93e-8 Red blood cell count; CRC trans rs7395662 0.553 rs4882155 chr11:48705801 T/C cg15704280 chr7:45808275 SEPT13 -0.52 -7.62 -0.39 2.7e-13 HDL cholesterol; CRC trans rs1814175 0.765 rs1721990 chr11:49912154 G/C cg03929089 chr4:120376271 NA -0.97 -18.64 -0.72 1.89e-53 Height; CRC cis rs57994353 0.897 rs66477686 chr9:139372224 T/C cg14119001 chr9:139324193 INPP5E -0.44 -6.17 -0.32 2.05e-9 Eosinophil counts;Cutaneous squamous cell carcinoma; CRC cis rs10911232 0.524 rs10911229 chr1:183050368 C/G ch.1.3577855R chr1:183094577 LAMC1 0.82 14.22 0.62 4.28e-36 Hypertriglyceridemia; CRC trans rs1005277 0.505 rs7099777 chr10:38183569 A/C cg17830980 chr10:43048298 ZNF37B 0.4 6.33 0.33 8.15e-10 Extrinsic epigenetic age acceleration; CRC cis rs7546094 0.935 rs7554345 chr1:113122956 T/G cg22162597 chr1:113214053 CAPZA1 0.43 6.08 0.32 3.31e-9 Platelet distribution width; CRC cis rs9660992 0.674 rs17345816 chr1:205262868 A/T cg21643547 chr1:205240462 TMCC2 0.45 7.27 0.37 2.72e-12 Mean corpuscular volume;Mean platelet volume; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg05913198 chr10:21822977 MLLT10 0.33 6.13 0.32 2.5e-9 Liver disease severity in Alagille syndrome; CRC cis rs561341 1.000 rs7214017 chr17:30332220 T/C cg23018236 chr17:30244563 NA -0.57 -7.44 -0.38 8.82e-13 Hip circumference adjusted for BMI; CRC cis rs4969178 0.965 rs56658017 chr17:76396164 G/A cg20026190 chr17:76395443 PGS1 0.41 6.25 0.33 1.31e-9 HDL cholesterol levels; CRC cis rs9926296 0.509 rs2159113 chr16:89832083 C/T cg27121462 chr16:89883253 FANCA 0.45 6.78 0.35 5.59e-11 Vitiligo; CRC cis rs13118159 0.742 rs7679860 chr4:1333987 C/T cg20092199 chr4:1342459 KIAA1530 0.44 7.54 0.38 4.65e-13 Longevity; CRC cis rs6754311 0.731 rs6719488 chr2:136575199 G/T cg25344623 chr2:136566232 LCT 0.32 5.81 0.31 1.47e-8 Mosquito bite size; CRC cis rs7605827 0.930 rs7595512 chr2:15678368 C/T cg19274914 chr2:15703543 NA 0.39 5.89 0.31 9.66e-9 Educational attainment (years of education); CRC cis rs28386778 0.700 rs11079515 chr17:62005645 C/G cg23090583 chr17:61904693 PSMC5;FTSJ3 -0.68 -10.28 -0.49 1.1e-21 Prudent dietary pattern; CRC cis rs1712517 0.740 rs11191663 chr10:105118462 C/T cg05636881 chr10:105038444 INA 0.47 8.08 0.41 1.2e-14 Migraine; CRC cis rs12325245 0.536 rs34737210 chr16:58549262 T/C cg21335942 chr16:58549945 SETD6 0.91 5.86 0.31 1.13e-8 Schizophrenia; CRC cis rs4065321 0.522 rs34648856 chr17:38149411 G/A cg17467752 chr17:38218738 THRA -0.5 -7.23 -0.37 3.39e-12 White blood cell count (basophil);White blood cell count; CRC cis rs10791097 0.720 rs6590518 chr11:130733530 C/T cg12179176 chr11:130786555 SNX19 0.7 11.05 0.52 2.3e-24 Autism spectrum disorder or schizophrenia;Schizophrenia; CRC cis rs4665809 1.000 rs17040322 chr2:26351274 G/C cg22920501 chr2:26401640 FAM59B -0.52 -7.15 -0.37 5.68e-12 Gut microbiome composition (summer); CRC cis rs8072100 0.846 rs7214799 chr17:45702099 C/T cg08085267 chr17:45401833 C17orf57 0.57 8.84 0.44 6.09e-17 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs6951245 0.938 rs112425403 chr7:1071531 A/G cg22907277 chr7:1156413 C7orf50 0.71 7.37 0.38 1.39e-12 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC trans rs10983614 1.000 rs7867776 chr9:120072627 A/G cg00473834 chr3:23987430 NR1D2 0.45 5.97 0.31 6.06e-9 Survival in pancreatic cancer; CRC cis rs1448094 0.512 rs7303330 chr12:86255123 G/A cg19622623 chr12:86230825 RASSF9 -0.41 -6.59 -0.34 1.7e-10 Major depressive disorder; CRC cis rs4332037 0.539 rs11764590 chr7:2032803 C/T cg13880726 chr7:1868755 MAD1L1 -0.49 -5.99 -0.31 5.45e-9 Bipolar disorder; CRC cis rs2276314 0.512 rs7234973 chr18:33450336 A/G cg05985134 chr18:33552581 C18orf21 0.4 5.97 0.31 6.3e-9 Endometriosis;Drug-induced torsades de pointes; CRC trans rs3780486 0.541 rs10738909 chr9:33148834 T/C cg04842962 chr6:43655489 MRPS18A 0.94 16.6 0.68 2.23e-45 IgG glycosylation; CRC cis rs7760949 0.889 rs9475795 chr6:13931270 A/C cg27413430 chr6:13925136 RNF182 0.34 6.02 0.32 4.56e-9 Mean corpuscular hemoglobin concentration; CRC cis rs9916302 0.904 rs3964723 chr17:37403979 C/T cg07936489 chr17:37558343 FBXL20 -0.81 -12.1 -0.55 3.95e-28 Glomerular filtration rate (creatinine); CRC cis rs1401999 0.674 rs562 chr3:183637845 T/C cg05044414 chr3:183734942 ABCC5 0.36 5.95 0.31 6.91e-9 Anterior chamber depth; CRC cis rs9611565 0.512 rs1534932 chr22:42150146 C/T cg03806693 chr22:41940476 POLR3H 1.02 12.07 0.55 4.94e-28 Vitiligo; CRC cis rs7208859 0.623 rs8075341 chr17:29136565 A/G cg01831904 chr17:28903510 LRRC37B2 -0.62 -6.41 -0.33 5.13e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs1862618 0.853 rs43184 chr5:56141777 G/C cg22800045 chr5:56110881 MAP3K1 0.58 6.38 0.33 6.16e-10 Initial pursuit acceleration; CRC cis rs9902453 0.845 rs10853135 chr17:28188675 G/A cg26525008 chr17:28256777 EFCAB5;SSH2 0.59 8.8 0.44 8.13e-17 Coffee consumption (cups per day); CRC cis rs8177253 0.665 rs8177178 chr3:133463272 G/A cg01448562 chr3:133502909 NA -0.43 -6.72 -0.35 8.02e-11 Iron status biomarkers; CRC cis rs67311347 1.000 rs17078916 chr3:40445438 C/T cg09455208 chr3:40491958 NA 0.47 8.97 0.44 2.25e-17 Renal cell carcinoma; CRC cis rs72717009 0.825 rs7529225 chr1:161479352 G/A cg23840854 chr1:161414152 NA -0.66 -7.95 -0.4 3.11e-14 Rheumatoid arthritis; CRC cis rs926938 0.527 rs1391484 chr1:115522366 A/G cg12756093 chr1:115239321 AMPD1 0.47 6.84 0.35 3.86e-11 Autism; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg13521891 chr12:95466445 NR2C1 0.44 6.4 0.33 5.22e-10 Response to antipsychotic treatment; CRC cis rs1005277 0.579 rs2474595 chr10:38426782 C/G cg25427524 chr10:38739819 LOC399744 0.75 12.95 0.58 2.8e-31 Extrinsic epigenetic age acceleration; CRC cis rs12541635 0.967 rs13256474 chr8:107086419 T/C cg10147462 chr8:107024639 NA -0.39 -6.49 -0.34 3.22e-10 Age of smoking initiation; CRC cis rs11098499 0.731 rs10015579 chr4:120271802 T/C cg09307838 chr4:120376055 NA 0.6 9.3 0.46 1.95e-18 Corneal astigmatism; CRC trans rs853679 0.882 rs3757188 chr6:28107357 T/C cg06606381 chr12:133084897 FBRSL1 -0.92 -7.56 -0.38 4e-13 Depression; CRC cis rs7512552 0.839 rs12046446 chr1:150460855 T/G cg15654264 chr1:150340011 RPRD2 0.61 8.36 0.42 1.83e-15 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); CRC cis rs853679 0.517 rs35227624 chr6:28132726 A/G cg03623178 chr6:28175578 NA 0.98 12.66 0.57 3.31e-30 Depression; CRC cis rs881375 1.000 rs10760118 chr9:123641616 C/T cg09419670 chr9:123605666 PSMD5;LOC253039 0.56 8.24 0.41 4.24e-15 Rheumatoid arthritis; CRC cis rs10876993 0.784 rs10083154 chr12:58020933 G/A cg15848620 chr12:58087721 OS9 0.59 7.89 0.4 4.56e-14 Celiac disease or Rheumatoid arthritis; CRC cis rs5756931 0.503 rs5750542 chr22:38534507 T/C cg25457927 chr22:38595422 NA -0.29 -6.02 -0.32 4.56e-9 Triglycerides; CRC cis rs7786808 0.712 rs2335167 chr7:158213948 A/C cg09998033 chr7:158218633 PTPRN2 -0.62 -8.6 -0.43 3.29e-16 Obesity-related traits; CRC cis rs2310173 0.575 rs719248 chr2:102623875 C/T cg20856504 chr2:102616538 IL1R2 0.38 6.06 0.32 3.75e-9 Ankylosing spondylitis;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined);Ulcerative colitis; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg19196182 chr12:99038046 IKBIP;APAF1 0.45 6.51 0.34 2.87e-10 Response to antipsychotic treatment; CRC cis rs7737355 0.898 rs4706030 chr5:130957486 A/G cg06307176 chr5:131281290 NA 0.45 6.48 0.34 3.44e-10 Life satisfaction; CRC cis rs10461617 0.617 rs79742142 chr5:56104377 A/G cg20203395 chr5:56204925 C5orf35 -0.72 -8.49 -0.42 7.3e-16 Type 2 diabetes; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg00007981 chr11:93862594 PANX1 0.42 6.04 0.32 4.08e-9 Intelligence (multi-trait analysis); CRC cis rs9733 0.519 rs12095002 chr1:150649249 G/A cg10589385 chr1:150898437 SETDB1 0.28 5.98 0.31 5.86e-9 Tonsillectomy; CRC cis rs9640161 0.742 rs2108854 chr7:150017408 C/T cg13722127 chr7:150037890 RARRES2 -0.48 -7.46 -0.38 7.65e-13 Blood protein levels;Circulating chemerin levels; CRC cis rs9467711 0.606 rs9379875 chr6:26444732 C/T cg16898833 chr6:26189333 HIST1H4D 0.94 7.65 0.39 2.25e-13 Autism spectrum disorder or schizophrenia; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg13804918 chr6:160182841 ACAT2 0.45 6.29 0.33 1.03e-9 Anxiety disorder; CRC cis rs9911578 1.000 rs4793952 chr17:56608465 C/T cg12560992 chr17:57184187 TRIM37 -0.91 -16.82 -0.68 3.08e-46 Intelligence (multi-trait analysis); CRC cis rs7254114 0.578 rs12980863 chr19:11309871 C/T cg02815516 chr19:11306319 KANK2 -0.33 -6.51 -0.34 2.73e-10 Immature fraction of reticulocytes; CRC cis rs12477438 0.765 rs1054042 chr2:99614396 G/T cg26064155 chr2:99771622 LIPT1;TSGA10 -0.64 -8.82 -0.44 6.82e-17 Chronic sinus infection; CRC cis rs1983891 0.954 rs4714481 chr6:41521110 T/C cg20194872 chr6:41519635 FOXP4 0.42 6.02 0.31 4.74e-9 Prostate cancer; CRC cis rs12594515 1.000 rs6493169 chr15:45986994 A/G cg01629716 chr15:45996671 NA -0.41 -8.47 -0.42 8.19e-16 Waist circumference;Weight; CRC cis rs9902453 0.833 rs7216631 chr17:28495112 A/G cg26525008 chr17:28256777 EFCAB5;SSH2 0.68 11.09 0.52 1.78e-24 Coffee consumption (cups per day); CRC cis rs11098499 0.779 rs10016060 chr4:120298412 A/G cg24375607 chr4:120327624 NA 0.51 7.86 0.4 5.5e-14 Corneal astigmatism; CRC cis rs4819052 1.000 rs733738 chr21:46666396 A/G cg19498844 chr21:46707878 POFUT2;LOC642852 -0.81 -10.52 -0.5 1.6400000000000001e-22 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs11098499 0.863 rs9884402 chr4:120489982 A/G cg24375607 chr4:120327624 NA 0.49 7.29 0.37 2.32e-12 Corneal astigmatism; CRC cis rs10504229 0.683 rs11786074 chr8:58133532 A/G cg24829409 chr8:58192753 C8orf71 -0.55 -8.03 -0.4 1.71e-14 Developmental language disorder (linguistic errors); CRC cis rs875971 0.862 rs801203 chr7:66023012 A/G cg18876405 chr7:65276391 NA -0.52 -8.41 -0.42 1.27e-15 Aortic root size; CRC trans rs1901167 1.000 rs7713884 chr5:40964816 C/A cg07701837 chr2:210516795 MAP2 0.37 6.02 0.31 4.64e-9 Cerebrospinal fluid biomarker levels; CRC cis rs4713118 0.739 rs2893931 chr6:27748010 G/A cg03623178 chr6:28175578 NA 0.7 9.33 0.46 1.61e-18 Parkinson's disease; CRC cis rs2160860 0.773 rs7824841 chr8:39799648 A/G cg11363097 chr8:39792086 IDO2 -0.45 -7.59 -0.39 3.31e-13 Blood metabolite levels; CRC cis rs111326718 1 rs111326718 chr10:104771211 A/AAAAAT cg15744005 chr10:104629667 AS3MT -0.32 -6.83 -0.35 4.22e-11 Reticulocyte count; CRC cis rs6951245 1.000 rs11770909 chr7:1086716 G/A cg04025307 chr7:1156635 C7orf50 0.64 6.64 0.34 1.3100000000000001e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs2153535 0.580 rs7741403 chr6:8530578 C/T cg07606381 chr6:8435919 SLC35B3 -0.67 -11.01 -0.52 3.18e-24 Motion sickness; CRC cis rs9329289 0.926 rs10903784 chr10:2541943 G/T cg05625103 chr10:2543513 NA -0.39 -6.13 -0.32 2.5e-9 Age-related hearing impairment; CRC cis rs877282 0.898 rs11253340 chr10:764786 G/T cg06581033 chr10:766294 NA -0.53 -5.88 -0.31 1.01e-8 Uric acid levels; CRC cis rs10504229 0.953 rs57131327 chr8:58171895 T/C cg02725872 chr8:58115012 NA -0.38 -6.43 -0.33 4.44e-10 Developmental language disorder (linguistic errors); CRC cis rs6951245 0.938 rs112425403 chr7:1071531 A/G cg20603222 chr7:1096387 C7orf50;GPR146 -0.69 -8.12 -0.41 9.65e-15 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs910316 0.783 rs11850751 chr14:75590113 A/T cg03030879 chr14:75389066 RPS6KL1 -0.47 -7.3 -0.37 2.13e-12 Height; CRC cis rs2565722 0.622 rs2489946 chr6:161301034 C/T cg03159191 chr6:161285451 NA -0.46 -6.28 -0.33 1.07e-9 Blood protein levels; CRC cis rs473651 0.777 rs550890 chr2:239332555 G/A cg08773314 chr2:239334832 ASB1 0.35 7.26 0.37 2.77e-12 Multiple system atrophy; CRC cis rs1218582 0.596 rs906595 chr1:154822907 C/T cg16680214 chr1:154839983 KCNN3 -0.42 -7.51 -0.38 5.56e-13 Prostate cancer; CRC cis rs73206853 0.563 rs56386451 chr12:111174516 A/G cg12870014 chr12:110450643 ANKRD13A 0.65 6.06 0.32 3.78e-9 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC cis rs727505 0.865 rs10253613 chr7:124508929 G/A cg23710748 chr7:124431027 NA -0.8 -14.18 -0.62 6.24e-36 Lewy body disease; CRC cis rs7615952 0.800 rs35390120 chr3:125599809 G/A cg05084668 chr3:125655381 ALG1L -0.72 -9.2 -0.45 4.26e-18 Blood pressure (smoking interaction); CRC cis rs3213545 0.700 rs2260445 chr12:121468863 C/A cg02403541 chr12:121454288 C12orf43 0.44 6.9 0.36 2.6e-11 Subjective well-being;Cardiovascular disease risk factors; CRC cis rs9322193 1.000 rs9767077 chr6:150109615 T/A cg05861140 chr6:150128134 PCMT1 -0.43 -7.05 -0.36 1.03e-11 Lung cancer; CRC cis rs67478160 0.634 rs2144079 chr14:104258884 C/T cg01849466 chr14:104193079 ZFYVE21 -0.54 -10.07 -0.49 5.64e-21 Schizophrenia; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg03860466 chr19:12912941 PRDX2 0.48 6.88 0.35 3.08e-11 Intelligence (multi-trait analysis); CRC cis rs208520 0.690 rs207108 chr6:66794096 T/C cg07460842 chr6:66804631 NA -1.09 -15.38 -0.65 1.37e-40 Exhaled nitric oxide output; CRC cis rs7632954 0.900 rs10866089 chr3:8514038 C/T cg03495237 chr3:8533978 NA 0.32 5.62 0.3 4.13e-8 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs11252926 0.800 rs2209625 chr10:747115 A/C cg03684893 chr10:554711 DIP2C 0.35 5.82 0.31 1.41e-8 Psychosis in Alzheimer's disease; CRC cis rs7725052 0.609 rs10063276 chr5:40476587 T/A cg09067459 chr5:40385259 NA 0.4 6.57 0.34 1.94e-10 Pediatric autoimmune diseases; CRC cis rs6502050 0.835 rs3924780 chr17:80112978 G/A cg11859384 chr17:80120422 CCDC57 -0.37 -5.85 -0.31 1.16e-8 Life satisfaction; CRC cis rs9549367 0.789 rs3794422 chr13:113893729 G/A cg18105134 chr13:113819100 PROZ -0.72 -10.34 -0.5 7.18e-22 Platelet distribution width; CRC cis rs4481887 0.962 rs5009868 chr1:248474495 A/G cg13385794 chr1:248469461 NA 0.4 6.83 0.35 4.21e-11 Common traits (Other); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg13038030 chr17:73267041 MIF4GD 0.43 5.99 0.31 5.62e-9 Response to antipsychotic treatment; CRC cis rs3091242 0.933 rs12402120 chr1:25751632 C/T cg20684491 chr1:25596433 NA 0.43 7.52 0.38 5.13e-13 Erythrocyte sedimentation rate; CRC cis rs9929218 0.817 rs8055912 chr16:68802068 C/T cg02972257 chr16:68554789 NA 0.44 5.61 0.3 4.28e-8 Colorectal cancer; CRC cis rs9660180 0.837 rs915292 chr1:1792157 A/C cg17747265 chr1:1875780 NA -0.77 -13.35 -0.59 8.43e-33 Body mass index; CRC cis rs713477 0.935 rs10144034 chr14:55914273 C/A cg21836586 chr14:55907198 TBPL2 0.31 5.62 0.3 4.1e-8 Pediatric bone mineral content (femoral neck); CRC cis rs7727544 0.636 rs2631365 chr5:131705949 T/C cg12564285 chr5:131593104 PDLIM4 -0.33 -5.88 -0.31 9.97e-9 Blood metabolite levels; CRC cis rs68170813 0.559 rs9641378 chr7:106868003 T/C cg02696742 chr7:106810147 HBP1 -0.61 -6.92 -0.36 2.41e-11 Coronary artery disease; CRC cis rs10256972 0.616 rs4585652 chr7:1145396 A/G cg18402987 chr7:1209562 NA 0.47 6.81 0.35 4.76e-11 Longevity;Endometriosis; CRC trans rs2303319 0.504 rs56039028 chr2:162516363 G/A cg12500891 chr11:57225987 NA -0.67 -6.03 -0.32 4.51e-9 Cognitive function; CRC trans rs1146361 1.000 rs1146361 chr1:116658817 T/C cg24991874 chr11:130066626 ST14 -0.54 -6.13 -0.32 2.48e-9 Fear of minor pain; CRC cis rs9322193 0.923 rs10782310 chr6:149943594 A/G cg13206674 chr6:150067644 NUP43 0.64 9.66 0.47 1.32e-19 Lung cancer; CRC trans rs2228479 0.850 rs9282681 chr16:89805914 T/C cg24644049 chr4:85504048 CDS1 0.87 7.15 0.37 5.65e-12 Skin colour saturation; CRC cis rs739401 0.619 rs10766480 chr11:2961325 G/A cg25174290 chr11:3078921 CARS 0.39 5.72 0.3 2.4e-8 Longevity; CRC cis rs6952808 0.531 rs3800922 chr7:2184505 A/G cg22963979 chr7:1858916 MAD1L1 -0.42 -5.94 -0.31 7.18e-9 Bipolar disorder and schizophrenia; CRC cis rs4237845 0.537 rs12312955 chr12:58265223 A/G cg00677455 chr12:58241039 CTDSP2 0.81 11.85 0.55 3.23e-27 Intelligence (multi-trait analysis); CRC cis rs11098499 0.754 rs12509621 chr4:120249660 T/C cg24375607 chr4:120327624 NA 0.47 7.6 0.39 3.06e-13 Corneal astigmatism; CRC cis rs9308731 0.644 rs3789064 chr2:111915322 T/C cg04202892 chr2:111875749 ACOXL 0.47 7.76 0.39 1.06e-13 Chronic lymphocytic leukemia; CRC trans rs16846053 0.681 rs62187563 chr2:162354653 G/A cg09481857 chr22:21368659 P2RX6;MGC16703 -0.64 -6.09 -0.32 3.2e-9 Blood osmolality (transformed sodium); CRC cis rs801193 0.967 rs34356500 chr7:66236607 G/T cg00343986 chr7:65444356 GUSB 0.46 6.77 0.35 5.91e-11 Aortic root size; CRC cis rs12760731 0.546 rs6699087 chr1:178433200 G/T cg00404053 chr1:178313656 RASAL2 0.74 8.77 0.44 9.65e-17 Obesity-related traits; CRC cis rs12291225 0.753 rs1431374 chr11:14303975 T/C cg05501817 chr11:14380813 RRAS2 -0.45 -5.88 -0.31 1.03e-8 Sense of smell; CRC cis rs9311474 0.508 rs4687629 chr3:52615227 G/C cg18099408 chr3:52552593 STAB1 -0.46 -7.97 -0.4 2.56e-14 Electroencephalogram traits; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg26761047 chr1:15944228 DDI2 0.48 6.89 0.36 2.89e-11 Response to antipsychotic treatment; CRC trans rs60843830 1.000 rs36216559 chr2:262335 A/G cg11347411 chr7:150020925 ACTR3C;LRRC61 0.59 9.21 0.45 3.84e-18 Spherical equivalent (joint analysis main effects and education interaction); CRC cis rs1577917 0.958 rs12212480 chr6:86458777 T/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.61 -7.69 -0.39 1.7e-13 Response to antipsychotic treatment; CRC cis rs7927592 0.956 rs11228269 chr11:68289796 A/G cg16797656 chr11:68205561 LRP5 0.37 5.85 0.31 1.19e-8 Total body bone mineral density; CRC cis rs2070488 0.965 rs13093640 chr3:38487176 A/G cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.91 16.81 0.68 3.37e-46 Electrocardiographic conduction measures; CRC cis rs17641971 0.662 rs1858312 chr8:49996521 G/A cg00325661 chr8:49890786 NA 0.37 6.28 0.33 1.08e-9 Blood metabolite levels; CRC trans rs9585327 0.584 rs4772260 chr13:100645723 A/G cg06583696 chr2:26101536 ASXL2 0.39 6.34 0.33 7.8e-10 Myopia; CRC cis rs1568889 0.667 rs7123947 chr11:28399908 A/G cg06544937 chr11:28130018 METT5D1;KIF18A 0.59 7.69 0.39 1.78e-13 Bipolar disorder; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg05224705 chr19:18112040 ARRDC2 0.4 6.42 0.33 4.65e-10 Liver disease severity in Alagille syndrome; CRC cis rs9399135 0.967 rs34546690 chr6:135369709 T/C cg22676075 chr6:135203613 NA 0.39 6.03 0.32 4.51e-9 Red blood cell count; CRC trans rs9858542 0.953 rs35115732 chr3:49475155 T/C cg21659725 chr3:3221576 CRBN -0.65 -8.85 -0.44 5.43e-17 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs3106136 0.934 rs34145031 chr4:95167123 A/G cg11021082 chr4:95130006 SMARCAD1 -0.47 -7.21 -0.37 3.78e-12 Capecitabine sensitivity; CRC cis rs6582630 0.555 rs12372536 chr12:38400864 C/G cg13010199 chr12:38710504 ALG10B 0.47 6.32 0.33 8.35e-10 Drug-induced liver injury (flucloxacillin); CRC cis rs9399137 0.507 rs6918512 chr6:135284839 T/G cg24558204 chr6:135376177 HBS1L 0.6 8.9 0.44 3.88e-17 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; CRC cis rs951366 0.966 rs11240565 chr1:205722958 C/T cg26354017 chr1:205819088 PM20D1 -0.41 -5.9 -0.31 9.15e-9 Menarche (age at onset); CRC cis rs826838 1.000 rs1719848 chr12:39085586 A/G cg26384229 chr12:38710491 ALG10B -0.61 -9.58 -0.47 2.49e-19 Heart rate; CRC cis rs4523957 0.928 rs11657644 chr17:2175210 C/G cg16513277 chr17:2031491 SMG6 -0.56 -9.38 -0.46 1.11e-18 Autism spectrum disorder or schizophrenia;Schizophrenia; CRC cis rs2204008 0.805 rs4882575 chr12:37940573 G/A cg13010199 chr12:38710504 ALG10B -0.51 -7.39 -0.38 1.22e-12 Bladder cancer; CRC cis rs2836974 0.897 rs2836932 chr21:40546717 G/A cg11644478 chr21:40555479 PSMG1 0.82 12.67 0.57 3.15e-30 Cognitive function; CRC cis rs10540 1.000 rs61876323 chr11:462855 G/A cg08200582 chr11:442649 ANO9 -0.69 -7.21 -0.37 3.75e-12 Body mass index; CRC cis rs7617773 0.963 rs6771787 chr3:48194242 C/T cg11946769 chr3:48343235 NME6 -0.51 -6.85 -0.35 3.73e-11 Coronary artery disease; CRC cis rs3091242 0.900 rs4649086 chr1:25778967 T/A cg23205692 chr1:25664452 TMEM50A 0.4 5.67 0.3 3.13e-8 Erythrocyte sedimentation rate; CRC cis rs7216064 1.000 rs56148300 chr17:65892752 T/C cg12091567 chr17:66097778 LOC651250 -0.63 -7.81 -0.4 7.55e-14 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg01861096 chr22:19279212 CLTCL1 0.43 6.78 0.35 5.72e-11 Liver disease severity in Alagille syndrome; CRC cis rs1865760 0.566 rs9348706 chr6:26065481 G/C cg18357526 chr6:26021779 HIST1H4A 0.43 6.06 0.32 3.81e-9 Height; CRC cis rs270601 0.770 rs4361510 chr5:131599647 C/T cg18758796 chr5:131593413 PDLIM4 0.48 8.79 0.44 8.41e-17 Acylcarnitine levels; CRC cis rs6952808 0.964 rs10950400 chr7:1882470 C/T cg04267008 chr7:1944627 MAD1L1 -0.76 -10.76 -0.51 2.4e-23 Bipolar disorder and schizophrenia; CRC cis rs1552244 1.000 rs9845756 chr3:10067548 G/C cg18598329 chr3:10140678 FANCD2;C3orf24 -0.89 -12.28 -0.56 8.67e-29 Alzheimer's disease; CRC cis rs28386778 1.000 rs2955241 chr17:61968113 G/C cg11494091 chr17:61959527 GH2 0.62 10.21 0.49 1.97e-21 Prudent dietary pattern; CRC cis rs6502050 0.835 rs3935403 chr17:80114145 C/T cg09264619 chr17:80180166 NA -0.35 -5.9 -0.31 8.84e-9 Life satisfaction; CRC cis rs4594175 0.926 rs4901084 chr14:51634131 G/A cg23942311 chr14:51606299 NA 0.63 10.16 0.49 2.84e-21 Cancer; CRC cis rs4713118 0.621 rs4713133 chr6:28034041 T/C cg12172441 chr6:28176163 NA 0.59 7.19 0.37 4.51e-12 Parkinson's disease; CRC cis rs28386778 0.897 rs2727323 chr17:61921999 G/T cg06601766 chr17:61851465 DDX42;CCDC47 0.42 5.8 0.3 1.53e-8 Prudent dietary pattern; CRC cis rs2019137 0.560 rs10206269 chr2:113990393 C/A cg11763394 chr2:113992921 PAX8;LOC440839;LOC654433 0.63 9.49 0.46 4.9e-19 Lymphocyte counts; CRC cis rs1577917 1.000 rs10944169 chr6:86683036 C/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.53 -6.91 -0.36 2.57e-11 Response to antipsychotic treatment; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg11797717 chr17:43198278 PLCD3 0.38 6.07 0.32 3.53e-9 Liver disease severity in Alagille syndrome; CRC cis rs9969804 0.905 rs9886781 chr9:95373251 T/C cg14631576 chr9:95140430 CENPP -0.32 -5.91 -0.31 8.49e-9 Height; CRC cis rs3820928 0.904 rs2195487 chr2:227759720 G/C cg11843606 chr2:227700838 RHBDD1 -0.41 -6.02 -0.31 4.74e-9 Pulmonary function; CRC cis rs875971 0.862 rs778705 chr7:65861115 G/A cg11764359 chr7:65958608 NA 0.57 8.44 0.42 1.01e-15 Aortic root size; CRC cis rs67311347 0.544 rs2278927 chr3:40350447 G/A cg09455208 chr3:40491958 NA 0.32 6.5 0.34 2.97e-10 Renal cell carcinoma; CRC cis rs1218582 0.710 rs9793588 chr1:154878878 C/G cg03351412 chr1:154909251 PMVK 0.55 8.86 0.44 5.15e-17 Prostate cancer; CRC cis rs939584 0.935 rs13396119 chr2:637508 T/C cg03610516 chr2:642275 NA 0.43 5.77 0.3 1.82e-8 Body mass index; CRC cis rs8180040 0.620 rs4683322 chr3:47093189 T/C cg10298567 chr3:47292165 KIF9 -0.4 -6.29 -0.33 1.04e-9 Colorectal cancer; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg19991689 chr14:59104318 DACT1 0.39 6.02 0.31 4.54e-9 Liver disease severity in Alagille syndrome; CRC cis rs875971 0.895 rs7782806 chr7:65657897 C/T cg00343986 chr7:65444356 GUSB -0.42 -5.98 -0.31 5.8e-9 Aortic root size; CRC cis rs796364 0.950 rs188146 chr2:200750444 C/T cg25936922 chr2:200820526 C2orf60;C2orf47 0.71 7.91 0.4 4e-14 Schizophrenia; CRC cis rs6951245 1.000 rs78158942 chr7:1090440 G/T cg20603222 chr7:1096387 C7orf50;GPR146 -0.73 -8.6 -0.43 3.34e-16 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs2011503 0.943 rs10406278 chr19:19494725 A/C cg11584989 chr19:19387371 SF4 -0.55 -6.36 -0.33 6.6e-10 Bipolar disorder; CRC cis rs8062405 0.737 rs11861132 chr16:28871860 A/G cg16576597 chr16:28551801 NUPR1 0.48 6.73 0.35 7.37e-11 Cognitive ability (multi-trait analysis);Cognitive ability; CRC trans rs4263408 0.934 rs9683743 chr4:39703194 A/C cg13440265 chr4:20701914 PACRGL -0.49 -7.2 -0.37 3.99e-12 Plasma amyloid beta peptide concentrations (ABx-40); CRC cis rs3858526 0.584 rs10742809 chr11:5862532 G/T cg26762873 chr11:5879799 OR52E8 0.46 6.98 0.36 1.66e-11 DNA methylation (variation); CRC cis rs7493 1.000 rs6968305 chr7:95042529 G/A cg04155289 chr7:94953770 PON1 -0.6 -7.43 -0.38 9.3e-13 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs6540556 0.723 rs12059226 chr1:209906675 A/G cg05527609 chr1:210001259 C1orf107 -0.52 -5.88 -0.31 1.02e-8 Red blood cell count; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg24441022 chr1:154946677 SHC1;CKS1B 0.41 5.97 0.31 6.02e-9 Intelligence (multi-trait analysis); CRC cis rs2380220 0.606 rs9488080 chr6:96006973 A/G cg04719120 chr6:96025338 MANEA 0.62 8.14 0.41 8.25e-15 Behavioural disinhibition (generation interaction); CRC cis rs4332037 0.539 rs11763750 chr7:2080114 G/A cg02421172 chr7:1938701 MAD1L1 0.43 5.77 0.3 1.79e-8 Bipolar disorder; CRC cis rs9322193 0.962 rs10214845 chr6:150104260 A/G cg00933542 chr6:150070202 PCMT1 0.28 5.63 0.3 3.86e-8 Lung cancer; CRC cis rs7089973 0.872 rs7923295 chr10:116625159 C/G cg23260525 chr10:116636907 FAM160B1 -0.31 -6.79 -0.35 5.26e-11 Bipolar disorder or attention deficit hyperactivity disorder; CRC cis rs4242434 0.787 rs1545837 chr8:22477807 T/C cg03733263 chr8:22462867 KIAA1967 0.98 17.36 0.69 2.17e-48 Exploratory eye movement dysfunction in schizophrenia (cognitive search score); CRC cis rs5769765 0.862 rs7410537 chr22:50317330 G/A cg22709217 chr22:50311962 ALG12;CRELD2 -1.05 -15.01 -0.64 3.85e-39 Schizophrenia; CRC cis rs1790761 0.587 rs4930431 chr11:67294308 C/T cg00290607 chr11:67383545 NA -0.34 -5.94 -0.31 7.18e-9 Mean corpuscular volume; CRC cis rs8005677 0.828 rs34584578 chr14:23411690 C/T cg25600027 chr14:23388339 RBM23 -0.42 -6.3 -0.33 9.66e-10 Cognitive ability (multi-trait analysis); CRC cis rs1964356 0.524 rs7839585 chr8:8854235 C/G cg11995313 chr8:8860691 ERI1 0.39 6.25 0.33 1.3e-9 Mean corpuscular volume; CRC cis rs4689592 0.587 rs3822269 chr4:7069901 T/C cg06697600 chr4:7070879 GRPEL1 -0.49 -7.08 -0.36 9.03e-12 Monocyte percentage of white cells; CRC trans rs1814175 0.645 rs1608632 chr11:49967148 C/T cg03929089 chr4:120376271 NA -0.91 -15.76 -0.66 4.29e-42 Height; CRC cis rs6499255 1.000 rs4985523 chr16:69797192 T/A cg04110750 chr16:69646130 NFAT5 -0.53 -7.11 -0.36 7.4e-12 IgE levels; CRC cis rs9926296 0.533 rs10852623 chr16:89865242 T/C cg21285383 chr16:89894308 SPIRE2 0.39 6.8 0.35 4.81e-11 Vitiligo; CRC cis rs459571 0.920 rs433402 chr9:136898627 A/G cg13789015 chr9:136890014 NCRNA00094 0.44 5.68 0.3 2.98e-8 Platelet distribution width; CRC cis rs7618915 0.547 rs2164884 chr3:52629633 C/T cg18404041 chr3:52824283 ITIH1 -0.43 -8.72 -0.43 1.39e-16 Bipolar disorder; CRC cis rs10847980 0.590 rs1696326 chr12:123311981 A/G cg25930673 chr12:123319894 HIP1R -0.72 -5.95 -0.31 6.69e-9 Adiponectin levels; CRC cis rs4332037 0.624 rs11766944 chr7:1888051 G/A cg23422044 chr7:1970798 MAD1L1 -0.49 -6.36 -0.33 6.72e-10 Bipolar disorder; CRC cis rs7112925 0.738 rs11227673 chr11:66832528 C/T cg24851651 chr11:66362959 CCS -0.33 -5.76 -0.3 1.95e-8 Height; CRC cis rs2398893 0.774 rs10993047 chr9:96846500 C/T cg14459158 chr9:96720562 NA -0.5 -7.96 -0.4 2.77e-14 Waist-hip ratio;Waist-to-hip ratio adjusted for body mass index; CRC cis rs10504229 0.906 rs7842855 chr8:58167718 G/C cg05313129 chr8:58192883 C8orf71 -0.45 -7.41 -0.38 1.1e-12 Developmental language disorder (linguistic errors); CRC cis rs9818758 0.556 rs116432667 chr3:48947589 C/T cg07636037 chr3:49044803 WDR6 -0.83 -6.8 -0.35 4.84e-11 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; CRC cis rs6495122 0.644 rs11630087 chr15:75261673 G/T cg09165964 chr15:75287851 SCAMP5 0.55 8.26 0.41 3.58e-15 Caffeine consumption;Diastolic blood pressure;Coffee consumption; CRC cis rs10463316 0.894 rs4099170 chr5:150766583 G/A cg03212797 chr5:150827313 SLC36A1 -0.5 -7.85 -0.4 6.1e-14 Metabolite levels (Pyroglutamine); CRC cis rs1552244 0.882 rs13063098 chr3:10009919 G/A cg10729496 chr3:10149963 C3orf24 0.51 6.7 0.35 9.12e-11 Alzheimer's disease; CRC cis rs3996993 0.597 rs10948728 chr6:52723635 C/T cg20803780 chr6:52668592 GSTA1 0.41 7.03 0.36 1.2e-11 Hemoglobin concentration; CRC trans rs2303319 0.504 rs1023835 chr2:162593973 A/G cg09481857 chr22:21368659 P2RX6;MGC16703 -0.65 -6.31 -0.33 9.13e-10 Cognitive function; CRC cis rs6502050 0.835 rs8071737 chr17:80117537 T/C cg13198984 chr17:80129470 CCDC57 0.46 8.18 0.41 6.3e-15 Life satisfaction; CRC cis rs1448094 0.512 rs12309296 chr12:86241566 T/C cg00310523 chr12:86230176 RASSF9 0.33 5.62 0.3 3.97e-8 Major depressive disorder; CRC cis rs2806561 0.715 rs10753550 chr1:23322471 C/G cg19743168 chr1:23544995 NA -0.37 -5.89 -0.31 9.49e-9 Height; CRC cis rs3733585 0.578 rs4466042 chr4:9955367 T/C cg11266682 chr4:10021025 SLC2A9 -0.47 -9.59 -0.47 2.27e-19 Cleft plate (environmental tobacco smoke interaction); CRC trans rs4263408 0.934 rs9683743 chr4:39703194 A/C cg01152455 chr12:88535851 TMTC3;CEP290 -0.4 -6.01 -0.31 4.84e-9 Plasma amyloid beta peptide concentrations (ABx-40); CRC cis rs9291683 0.609 rs13149985 chr4:10028390 G/A cg11266682 chr4:10021025 SLC2A9 0.53 11.18 0.52 7.96e-25 Bone mineral density; CRC cis rs7208859 0.673 rs36056619 chr17:29172284 T/C cg01831904 chr17:28903510 LRRC37B2 -0.55 -5.72 -0.3 2.33e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs344364 0.511 rs911391 chr16:1947016 C/A cg00046913 chr16:1877150 HAGH;FAHD1 -0.6 -6.19 -0.32 1.78e-9 Glomerular filtration rate in chronic kidney disease; CRC cis rs9549367 0.865 rs9549366 chr13:113907644 G/A cg18105134 chr13:113819100 PROZ -0.75 -11.01 -0.52 3.14e-24 Platelet distribution width; CRC cis rs10504229 0.679 rs17801003 chr8:58050930 A/G cg22535103 chr8:58192502 C8orf71 -0.67 -7.5 -0.38 6.13e-13 Developmental language disorder (linguistic errors); CRC cis rs11628318 0.508 rs3950014 chr14:103069889 G/A cg08075719 chr14:103021372 NA -0.68 -7.93 -0.4 3.47e-14 Platelet count; CRC cis rs10876993 0.928 rs2640637 chr12:58077586 G/A cg18357645 chr12:58087776 OS9 0.63 8.97 0.44 2.28e-17 Celiac disease or Rheumatoid arthritis; CRC cis rs17376456 0.877 rs10514380 chr5:93409370 C/T cg25358565 chr5:93447407 FAM172A 0.98 10.51 0.5 1.85e-22 Diabetic retinopathy; CRC cis rs9361491 0.657 rs9352625 chr6:79454754 G/A cg05283184 chr6:79620031 NA -0.38 -5.79 -0.3 1.68e-8 Intelligence (multi-trait analysis); CRC cis rs6952808 0.792 rs12537914 chr7:1948359 C/T cg02951883 chr7:2050386 MAD1L1 -0.69 -10.8 -0.51 1.8e-23 Bipolar disorder and schizophrenia; CRC cis rs7824557 0.510 rs2736297 chr8:11234885 C/G cg08071915 chr8:12219732 FAM66A 0.31 5.65 0.3 3.47e-8 Retinal vascular caliber; CRC cis rs977987 0.806 rs7199132 chr16:75450039 C/T cg03315344 chr16:75512273 CHST6 0.54 9.08 0.45 1.04e-17 Dupuytren's disease; CRC trans rs877282 0.853 rs11595507 chr10:756703 C/T cg22713356 chr15:30763199 NA 1.19 13.88 0.61 8.17e-35 Uric acid levels; CRC cis rs4356975 0.545 rs35749478 chr4:69949580 A/T cg25583503 chr4:69962676 UGT2B7 -0.31 -5.68 -0.3 2.92e-8 Obesity-related traits; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg19935506 chr2:242626874 DTYMK 0.47 6.06 0.32 3.75e-9 Thyroid stimulating hormone; CRC trans rs1656966 1.000 rs1656966 chr3:186466252 C/T cg07596482 chr17:42633968 FZD2 0.41 6.06 0.32 3.7e-9 Myopia (pathological); CRC cis rs9903692 0.789 rs12601675 chr17:46190928 T/C cg21215337 chr17:46176117 CBX1 -0.43 -7.95 -0.4 2.95e-14 Pulse pressure; CRC cis rs8062405 0.690 rs762634 chr16:28603335 T/C cg16576597 chr16:28551801 NUPR1 0.51 7.06 0.36 9.72e-12 Cognitive ability (multi-trait analysis);Cognitive ability; CRC cis rs6951245 0.832 rs79808627 chr7:1092519 C/G cg21664854 chr7:1097933 C7orf50;GPR146 0.63 7.84 0.4 6.22e-14 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs11229555 0.645 rs11229435 chr11:58185796 G/C cg15696309 chr11:58395628 NA -0.81 -10.31 -0.49 8.83e-22 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; CRC cis rs875971 0.660 rs801217 chr7:66010577 C/T cg25985355 chr7:65971099 NA 0.32 5.78 0.3 1.75e-8 Aortic root size; CRC cis rs798554 0.591 rs757791 chr7:2867296 A/G cg13628971 chr7:2884303 GNA12 0.43 6.7 0.35 9e-11 Height; CRC trans rs7395662 1.000 rs11039777 chr11:48517049 T/G cg21153622 chr11:89784906 NA -0.44 -7.1 -0.36 7.5e-12 HDL cholesterol; CRC cis rs1448094 0.935 rs11117108 chr12:86322310 T/A cg18827107 chr12:86230957 RASSF9 -0.37 -6.12 -0.32 2.61e-9 Major depressive disorder; CRC cis rs992157 0.835 rs10932768 chr2:219146199 T/A cg04880052 chr2:219191631 PNKD -0.44 -6.94 -0.36 2.1e-11 Colorectal cancer; CRC cis rs9326248 1.000 rs9326248 chr11:116999225 A/C cg10130564 chr11:117069849 TAGLN 0.34 6.11 0.32 2.87e-9 Blood protein levels; CRC cis rs4731207 0.596 rs10239507 chr7:124596785 T/C cg23710748 chr7:124431027 NA -0.38 -6.08 -0.32 3.35e-9 Cutaneous malignant melanoma; CRC cis rs847577 0.609 rs11765552 chr7:97822115 T/A cg00277769 chr7:97922759 BAIAP2L1 -0.41 -6.88 -0.35 2.99e-11 Breast cancer; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg24761882 chr9:96214934 FAM120AOS;FAM120A 0.42 6.04 0.32 4.07e-9 Intelligence (multi-trait analysis); CRC cis rs7113874 0.610 rs12576736 chr11:8512281 A/C cg17679104 chr11:8615758 STK33 -0.36 -5.92 -0.31 8.19e-9 Body mass index in physically active individuals;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs926392 0.572 rs6129156 chr20:37672209 A/C cg16355469 chr20:37678765 NA 0.45 6.75 0.35 6.72e-11 Dialysis-related mortality; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg23239078 chr11:2907332 CDKN1C 0.48 6.81 0.35 4.73e-11 Anxiety disorder; CRC cis rs3733585 0.673 rs6849729 chr4:9958732 T/C cg11266682 chr4:10021025 SLC2A9 -0.47 -9.67 -0.47 1.2e-19 Cleft plate (environmental tobacco smoke interaction); CRC cis rs1707322 1.000 rs1768807 chr1:46510570 A/G cg06784218 chr1:46089804 CCDC17 -0.55 -9.74 -0.47 7.43e-20 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs10504229 0.728 rs72650855 chr8:58152570 A/G cg05313129 chr8:58192883 C8orf71 -0.47 -6.18 -0.32 1.94e-9 Developmental language disorder (linguistic errors); CRC cis rs7843479 0.509 rs3758156 chr8:21770796 A/G cg08288130 chr8:21771540 DOK2 0.28 5.66 0.3 3.33e-8 Mean corpuscular volume; CRC cis rs7666738 0.830 rs6853266 chr4:99047528 G/T cg17366294 chr4:99064904 C4orf37 0.47 7.98 0.4 2.39e-14 Colonoscopy-negative controls vs population controls; CRC cis rs7208859 0.673 rs2470251 chr17:29095061 T/C cg13385521 chr17:29058706 SUZ12P 0.58 7.32 0.37 1.86e-12 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs801193 1.000 rs2707836 chr7:66160435 A/C cg25985355 chr7:65971099 NA -0.32 -5.62 -0.3 3.97e-8 Aortic root size; CRC cis rs7216064 0.953 rs80135947 chr17:65836001 A/C cg12091567 chr17:66097778 LOC651250 -0.67 -7.67 -0.39 1.97e-13 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CRC cis rs10504229 0.871 rs10504227 chr8:58162005 G/A cg22535103 chr8:58192502 C8orf71 -0.7 -10.52 -0.5 1.6400000000000001e-22 Developmental language disorder (linguistic errors); CRC cis rs79839061 0.610 rs3775130 chr4:875144 G/A cg07828340 chr4:882639 GAK 1.12 10.48 0.5 2.32e-22 Intelligence (multi-trait analysis); CRC cis rs28386778 0.897 rs2727323 chr17:61921999 G/T cg07362569 chr17:61921086 SMARCD2 0.37 5.71 0.3 2.47e-8 Prudent dietary pattern; CRC cis rs12477438 0.520 rs11123766 chr2:99780915 C/T cg26064155 chr2:99771622 LIPT1;TSGA10 0.87 15.96 0.66 7.31e-43 Chronic sinus infection; CRC cis rs12900413 0.687 rs13343250 chr15:90311410 T/C cg24249390 chr15:90295951 MESP1 -0.58 -9.3 -0.46 1.95e-18 Coronary artery aneurysm in Kawasaki disease; CRC cis rs832540 0.966 rs33321 chr5:56206073 G/T cg24531977 chr5:56204891 C5orf35 -0.5 -7.67 -0.39 1.94e-13 Coronary artery disease; CRC trans rs1814175 0.904 rs7924371 chr11:49620595 C/T cg03929089 chr4:120376271 NA -0.94 -17.32 -0.69 3.26e-48 Height; CRC trans rs11098499 0.780 rs10013652 chr4:120292256 A/G cg25214090 chr10:38739885 LOC399744 0.61 9.62 0.47 1.82e-19 Corneal astigmatism; CRC cis rs7772486 0.658 rs9403737 chr6:145962193 G/T cg23711669 chr6:146136114 FBXO30 0.74 12.69 0.57 2.68e-30 Lobe attachment (rater-scored or self-reported); CRC cis rs1003719 0.762 rs1015551 chr21:38449510 G/A cg10648535 chr21:38446584 PIGP;TTC3 0.53 7.54 0.38 4.76e-13 Eye color traits; CRC cis rs7089973 0.872 rs34064819 chr10:116621154 C/A cg03647239 chr10:116582469 FAM160B1 0.41 5.71 0.3 2.59e-8 Bipolar disorder or attention deficit hyperactivity disorder; CRC cis rs4713118 0.662 rs9468274 chr6:28026077 G/T cg06470822 chr6:28175283 NA 0.95 13.58 0.6 1.14e-33 Parkinson's disease; CRC cis rs4713118 0.869 rs6901520 chr6:27714575 G/T cg02683197 chr6:28174875 NA 0.63 8.77 0.44 9.62e-17 Parkinson's disease; CRC trans rs3805389 0.504 rs28416150 chr4:56474378 C/T cg23217153 chr2:242808611 NA -0.45 -6.05 -0.32 3.83e-9 Waist-to-hip ratio adjusted for body mass index; CRC cis rs7772486 0.846 rs2492856 chr6:146323928 A/G cg23711669 chr6:146136114 FBXO30 0.61 10.08 0.49 5.45e-21 Lobe attachment (rater-scored or self-reported); CRC cis rs2257205 0.588 rs77430462 chr17:56804085 C/G cg25885038 chr17:56607967 SEPT4 -0.52 -5.71 -0.3 2.5e-8 Pancreatic cancer; CRC cis rs6484504 0.652 rs494464 chr11:31386150 C/T cg14844989 chr11:31128820 NA 0.35 6.18 0.32 1.94e-9 Red blood cell count; CRC cis rs7737355 1.000 rs798412 chr5:130698474 C/A cg06307176 chr5:131281290 NA -0.39 -5.73 -0.3 2.33e-8 Life satisfaction; CRC cis rs11098499 0.954 rs3733520 chr4:120423480 C/G cg09307838 chr4:120376055 NA 0.73 11.24 0.53 4.86e-25 Corneal astigmatism; CRC cis rs514406 0.858 rs574853 chr1:53310959 A/T cg08859206 chr1:53392774 SCP2 -0.45 -6.99 -0.36 1.54e-11 Monocyte count; CRC cis rs55702914 0.712 rs6730590 chr2:198148084 A/G cg03934865 chr2:198174659 NA -0.36 -6.22 -0.32 1.5e-9 Major depression and alcohol dependence; CRC cis rs11122272 0.735 rs2009873 chr1:231499236 C/T cg06096015 chr1:231504339 EGLN1 0.4 6.05 0.32 3.99e-9 Hemoglobin concentration; CRC trans rs561341 1.000 rs501957 chr17:30314504 C/T cg27661571 chr11:113659931 NA -0.89 -10.36 -0.5 5.8e-22 Hip circumference adjusted for BMI; CRC cis rs9911578 1.000 rs9901181 chr17:56964271 C/T cg12560992 chr17:57184187 TRIM37 0.92 16.97 0.68 7.49e-47 Intelligence (multi-trait analysis); CRC cis rs28386778 0.863 rs58269663 chr17:61843130 G/A cg06873352 chr17:61820015 STRADA 0.79 14.96 0.64 5.82e-39 Prudent dietary pattern; CRC cis rs12451471 0.559 rs12452263 chr17:78079310 T/C cg12100956 chr17:78086420 GAA -0.38 -6.08 -0.32 3.39e-9 Plateletcrit;Mean corpuscular hemoglobin concentration; CRC cis rs3820068 0.581 rs72645871 chr1:15926142 G/A cg13390004 chr1:15929781 NA 0.5 7.09 0.36 8.36e-12 Systolic blood pressure; CRC cis rs6743226 0.840 rs10933549 chr2:242240702 A/G cg10021735 chr2:242295487 FARP2 0.48 6.96 0.36 1.9e-11 Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI in non-smokers; CRC trans rs3942852 0.759 rs905475 chr11:48149755 C/T cg03929089 chr4:120376271 NA -0.56 -7.15 -0.37 5.78e-12 Acute lymphoblastic leukemia (childhood); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg24057373 chr1:100818342 CDC14A 0.4 6.54 0.34 2.39e-10 Liver disease severity in Alagille syndrome; CRC cis rs35306767 0.807 rs34885925 chr10:919032 G/C cg26597838 chr10:835615 NA 1.23 14.81 0.63 2.18e-38 Eosinophil percentage of granulocytes; CRC cis rs1448094 0.511 rs10779210 chr12:86162432 T/C cg25456477 chr12:86230367 RASSF9 -0.33 -5.63 -0.3 3.81e-8 Major depressive disorder; CRC cis rs4290604 0.748 rs10754942 chr2:238075187 T/C cg23555395 chr2:238036564 NA -0.61 -6.18 -0.32 1.86e-9 Asthma; CRC cis rs3812762 0.912 rs4929936 chr11:8792622 C/T cg00186954 chr11:8933980 ST5;C11orf17 -0.41 -6.38 -0.33 5.97e-10 Hypospadias; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg19990379 chr1:145611441 POLR3C;RNF115 0.46 6.09 0.32 3.21e-9 Anxiety disorder; CRC cis rs10782582 0.632 rs77099976 chr1:76240524 T/C cg10523679 chr1:76189770 ACADM -0.4 -5.62 -0.3 4.07e-8 Daytime sleep phenotypes; CRC cis rs12586317 0.547 rs3759548 chr14:35450333 C/T cg05294307 chr14:35346193 BAZ1A -0.72 -7.85 -0.4 6e-14 Psoriasis; CRC cis rs10504229 0.610 rs6987118 chr8:58147851 G/T cg21724239 chr8:58056113 NA 0.43 6.31 0.33 8.95e-10 Developmental language disorder (linguistic errors); CRC cis rs853679 1.000 rs2799079 chr6:28235176 A/C cg15845792 chr6:28175446 NA 0.6 6.37 0.33 6.2e-10 Depression; CRC cis rs910316 0.737 rs175077 chr14:75506875 G/A cg08847533 chr14:75593920 NEK9 -0.87 -15.02 -0.64 3.5e-39 Height; CRC cis rs6570726 0.846 rs1935616 chr6:145943512 C/T cg23711669 chr6:146136114 FBXO30 0.64 10.62 0.51 7.3e-23 Lobe attachment (rater-scored or self-reported); CRC cis rs6963495 0.818 rs73190156 chr7:105153567 C/T cg02135003 chr7:105160482 PUS7 -0.9 -12.2 -0.56 1.71e-28 Bipolar disorder (body mass index interaction); CRC cis rs28386778 0.742 rs3020617 chr17:61947303 A/G cg11494091 chr17:61959527 GH2 0.59 9.76 0.47 6.07e-20 Prudent dietary pattern; CRC cis rs9837602 1.000 rs793472 chr3:99546110 A/G cg07805332 chr3:99536008 MIR548G;C3orf26 0.47 6.32 0.33 8.37e-10 Breast cancer; CRC cis rs7249142 0.562 rs2314035 chr19:19284920 T/C cg26504305 chr19:19281019 LOC729991-MEF2B;MEF2B -0.45 -9.1 -0.45 9.16e-18 IgG glycosylation; CRC cis rs35883536 1.000 rs1832121 chr1:101159476 A/G cg14515779 chr1:101123966 NA -0.35 -6.3 -0.33 9.5e-10 Monocyte count; CRC cis rs597539 0.652 rs668576 chr11:68668208 A/G cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.89 15.41 0.65 1.03e-40 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs10256972 0.591 rs6968988 chr7:1169619 A/G cg22907277 chr7:1156413 C7orf50 0.67 10.56 0.5 1.19e-22 Longevity;Endometriosis; CRC cis rs11148252 0.514 rs1886539 chr13:52726090 C/T cg00495681 chr13:53174319 NA 0.55 8.0 0.4 2.1e-14 Lewy body disease; CRC cis rs6604026 0.656 rs2774954 chr1:93363525 G/A cg17283838 chr1:93427260 FAM69A -0.43 -5.79 -0.3 1.61e-8 Multiple sclerosis; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg03189282 chr8:37962497 ASH2L 0.38 5.96 0.31 6.5e-9 Liver disease severity in Alagille syndrome; CRC cis rs2213920 0.619 rs6478174 chr9:118252779 C/T cg13918206 chr9:118159781 DEC1 0.61 5.63 0.3 3.8e-8 Docetaxel-induced peripheral neuropathy in metastatic castrate-resistant prostate cancer; CRC cis rs704795 0.805 rs1728926 chr2:27612937 A/G cg12648201 chr2:27665141 KRTCAP3 -0.29 -5.76 -0.3 1.94e-8 Menopause (age at onset); CRC cis rs6840360 1.000 rs6535821 chr4:152678974 T/C cg09659197 chr4:152720779 NA 0.53 11.58 0.54 3.16e-26 Intelligence (multi-trait analysis); CRC trans rs1814175 0.817 rs7924619 chr11:49620632 G/A cg11707556 chr5:10655725 ANKRD33B -0.43 -8.12 -0.41 9.45e-15 Height; CRC cis rs28386778 0.897 rs1062791 chr17:61896487 C/T cg11494091 chr17:61959527 GH2 0.6 10.17 0.49 2.58e-21 Prudent dietary pattern; CRC trans rs10838801 1 rs10838801 chr11:48098280 G/A cg03929089 chr4:120376271 NA -0.6 -8.23 -0.41 4.37e-15 Height; CRC cis rs12142240 0.698 rs4372193 chr1:46853233 G/T cg00530320 chr1:46809349 NSUN4 0.59 8.07 0.41 1.35e-14 Menopause (age at onset); CRC cis rs9318086 0.935 rs2025701 chr13:24440581 A/G cg25267304 chr13:24462978 PCOTH;MIPEP 0.62 10.1 0.49 4.43e-21 Myopia (pathological); CRC cis rs6120849 0.663 rs13041792 chr20:33545055 G/A cg24642439 chr20:33292090 TP53INP2 0.44 5.79 0.3 1.64e-8 Protein C levels; CRC cis rs9487051 0.737 rs1260593 chr6:109521400 C/T cg21918786 chr6:109611834 NA -0.33 -5.72 -0.3 2.33e-8 Reticulocyte fraction of red cells; CRC cis rs10979 0.931 rs9403509 chr6:143888691 G/A cg25407410 chr6:143891975 LOC285740 -0.82 -13.4 -0.59 5.5e-33 Hypospadias; CRC cis rs6484504 0.576 rs2616792 chr11:31324298 T/G cg14844989 chr11:31128820 NA 0.36 6.45 0.33 4.06e-10 Red blood cell count; CRC cis rs4750440 0.702 rs7917812 chr10:14030067 G/A cg00551146 chr10:14014579 FRMD4A 0.37 5.9 0.31 8.89e-9 Adiponectin levels; CRC cis rs6681460 1.000 rs4655648 chr1:67114309 C/T cg02459107 chr1:67143332 SGIP1 0.46 7.98 0.4 2.44e-14 Presence of antiphospholipid antibodies; CRC cis rs10504229 0.683 rs35889486 chr8:58117749 T/A cg05313129 chr8:58192883 C8orf71 -0.43 -6.11 -0.32 2.74e-9 Developmental language disorder (linguistic errors); CRC cis rs35306767 0.953 rs35693858 chr10:979813 C/T cg26597838 chr10:835615 NA 0.87 10.66 0.51 5.61e-23 Eosinophil percentage of granulocytes; CRC cis rs2742417 1.000 rs2251954 chr3:45731784 A/G cg04837898 chr3:45731254 SACM1L -0.35 -5.75 -0.3 2.03e-8 Response to anti-depressant treatment in major depressive disorder; CRC cis rs9303401 0.592 rs66583824 chr17:56639853 C/T cg02118635 chr17:56770003 RAD51C;TEX14 0.78 9.77 0.47 5.98e-20 Cognitive test performance; CRC cis rs1552244 0.572 rs3894323 chr3:10168967 G/A cg08888203 chr3:10149979 C3orf24 0.71 8.58 0.43 3.91e-16 Alzheimer's disease; CRC cis rs7617773 0.817 rs9847953 chr3:48282695 A/G cg11946769 chr3:48343235 NME6 0.64 8.8 0.44 7.65e-17 Coronary artery disease; CRC cis rs12618769 0.597 rs3769712 chr2:99153443 A/T cg18455616 chr2:99124870 INPP4A 0.36 5.92 0.31 8.23e-9 Bipolar disorder; CRC cis rs7216064 0.553 rs62084690 chr17:66035411 A/G cg12091567 chr17:66097778 LOC651250 0.68 9.66 0.47 1.32e-19 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CRC cis rs1953600 0.645 rs2819950 chr10:81935279 G/A cg27417294 chr10:81904244 PLAC9 -0.37 -5.83 -0.31 1.29e-8 Sarcoidosis; CRC cis rs611744 0.608 rs667742 chr8:109254003 T/C cg18478394 chr8:109455254 TTC35 0.37 5.78 0.3 1.75e-8 Dupuytren's disease; CRC cis rs1552244 1.000 rs17032299 chr3:10087638 C/T cg00166722 chr3:10149974 C3orf24 0.7 9.58 0.47 2.5e-19 Alzheimer's disease; CRC cis rs4713118 0.621 rs9295755 chr6:28033174 C/T cg02631126 chr6:28058918 ZSCAN12L1 -0.27 -5.69 -0.3 2.87e-8 Parkinson's disease; CRC trans rs1656966 1.000 rs1656966 chr3:186466252 C/T cg06391300 chr11:119600292 PVRL1 0.41 6.02 0.31 4.58e-9 Myopia (pathological); CRC cis rs61996546 0.622 rs34916314 chr15:26833559 A/G cg15066197 chr15:26874202 GABRB3 -0.41 -6.06 -0.32 3.78e-9 Response to methotrexate in juvenile idiopathic arthritis; CRC cis rs9916302 0.904 rs4795359 chr17:37573146 C/T cg00129232 chr17:37814104 STARD3 -0.54 -8.09 -0.41 1.15e-14 Glomerular filtration rate (creatinine); CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg23134169 chr19:16682794 SLC35E1 0.49 6.34 0.33 7.71e-10 Thyroid stimulating hormone; CRC cis rs362296 0.511 rs2857861 chr4:3323767 C/T cg08886695 chr4:3369023 RGS12 -0.4 -6.36 -0.33 6.59e-10 Parental longevity (mother's age at death); CRC cis rs9304742 0.962 rs12459008 chr19:53454789 A/T cg09915433 chr19:53449742 NA 0.57 8.63 0.43 2.64e-16 Psoriasis; CRC cis rs4523957 0.928 rs216180 chr17:2172416 C/G cg16513277 chr17:2031491 SMG6 0.54 9.26 0.45 2.67e-18 Autism spectrum disorder or schizophrenia;Schizophrenia; CRC cis rs7044106 0.537 rs4434680 chr9:123489688 A/G cg14255062 chr9:123606675 PSMD5;LOC253039 0.46 5.98 0.31 5.7e-9 Hip circumference adjusted for BMI; CRC cis rs28374715 0.733 rs9568 chr15:41573612 G/T cg18705301 chr15:41695430 NDUFAF1 -0.92 -15.28 -0.64 3.3e-40 Ulcerative colitis; CRC cis rs367943 1.000 rs348952 chr5:112821990 G/T cg12552261 chr5:112820674 MCC -0.49 -7.58 -0.39 3.45e-13 Type 2 diabetes; CRC cis rs2404602 0.684 rs11854850 chr15:76844571 C/T cg03037974 chr15:76606532 NA -0.51 -7.61 -0.39 3.01e-13 Blood metabolite levels; CRC cis rs4253772 0.550 rs738444 chr22:46721088 C/T cg09491104 chr22:46646882 C22orf40 -0.43 -6.6 -0.34 1.67e-10 LDL cholesterol;Cholesterol, total; CRC cis rs748404 0.697 rs579651 chr15:43558376 T/C cg02155558 chr15:43621948 ADAL;LCMT2 0.42 6.25 0.33 1.28e-9 Lung cancer; CRC cis rs8177179 0.967 rs6782434 chr3:133438834 C/G cg16262614 chr3:133464971 TF 0.51 9.56 0.47 2.88e-19 Iron status biomarkers (transferrin levels); CRC cis rs881375 0.935 rs7034390 chr9:123646488 A/T cg09586646 chr9:123605570 PSMD5;LOC253039 0.49 6.74 0.35 7.01e-11 Rheumatoid arthritis; CRC cis rs1953600 0.645 rs2819950 chr10:81935279 G/A cg11900509 chr10:81946545 ANXA11 0.39 6.39 0.33 5.54e-10 Sarcoidosis; CRC cis rs1552244 1.000 rs55822690 chr3:10128003 A/G cg02579736 chr3:10068473 FANCD2;CIDECP 1.01 13.5 0.6 2.41e-33 Alzheimer's disease; CRC cis rs7727544 0.716 rs4705926 chr5:131561758 C/T cg22638593 chr5:131593259 PDLIM4 0.35 6.37 0.33 6.2e-10 Blood metabolite levels; CRC cis rs3087591 0.922 rs2905806 chr17:29502507 A/G cg24425628 chr17:29625626 OMG;NF1 0.84 15.73 0.66 5.61e-42 Hip circumference; CRC trans rs8005745 0.505 rs710047 chr14:62118819 C/G cg20982606 chr12:109535391 UNG -0.43 -6.04 -0.32 4.14e-9 Select biomarker traits; CRC cis rs3772130 0.583 rs4296627 chr3:121567684 G/A cg20356878 chr3:121714668 ILDR1 0.37 6.08 0.32 3.24e-9 Cognitive performance; CRC cis rs6120849 0.707 rs3746444 chr20:33578251 A/G cg08999081 chr20:33150536 PIGU 0.45 5.84 0.31 1.25e-8 Protein C levels; CRC trans rs7615952 0.599 rs6766327 chr3:125723677 C/G cg07211511 chr3:129823064 LOC729375 -0.78 -10.81 -0.51 1.6e-23 Blood pressure (smoking interaction); CRC trans rs9329221 0.537 rs6983332 chr8:9977918 A/G cg06636001 chr8:8085503 FLJ10661 -0.5 -7.45 -0.38 8.2e-13 Neuroticism; CRC cis rs9393777 0.920 rs35120058 chr6:27358166 A/G cg15845792 chr6:28175446 NA 0.87 5.64 0.3 3.73e-8 Intelligence (multi-trait analysis); CRC cis rs6543140 0.964 rs10193485 chr2:103089573 T/C cg03938978 chr2:103052716 IL18RAP 0.42 6.67 0.35 1.06e-10 Blood protein levels; CRC cis rs921968 0.643 rs596076 chr2:219451015 T/G cg02176678 chr2:219576539 TTLL4 0.49 7.95 0.4 3.08e-14 Mean corpuscular hemoglobin concentration; CRC cis rs4523957 0.963 rs216178 chr17:2168840 T/C cg16513277 chr17:2031491 SMG6 0.56 9.54 0.47 3.26e-19 Autism spectrum disorder or schizophrenia;Schizophrenia; CRC cis rs798554 0.610 rs2644297 chr7:2858906 A/C cg19717773 chr7:2847554 GNA12 -0.47 -8.06 -0.41 1.4e-14 Height; CRC cis rs11148252 0.508 rs6561671 chr13:53182314 G/A cg20354231 chr13:53171401 NA -0.51 -8.23 -0.41 4.57e-15 Lewy body disease; CRC cis rs4713118 0.586 rs9468290 chr6:28087674 C/T cg12172441 chr6:28176163 NA 0.62 7.27 0.37 2.56e-12 Parkinson's disease; CRC cis rs4843747 0.518 rs4072777 chr16:88107030 G/A cg07865391 chr16:88106882 BANP 0.46 6.05 0.32 3.86e-9 Menopause (age at onset); CRC cis rs875971 0.545 rs1796226 chr7:66087710 C/T cg11764359 chr7:65958608 NA 0.46 5.79 0.3 1.64e-8 Aortic root size; CRC cis rs10771431 1.000 rs10771431 chr12:9380859 C/T cg08997352 chr12:9597637 DDX12 -0.39 -5.79 -0.3 1.61e-8 Breast size; CRC cis rs10046574 0.519 rs7781819 chr7:135205700 A/T cg27474649 chr7:135195673 CNOT4 0.62 5.99 0.31 5.57e-9 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs9522267 0.535 rs9515454 chr13:112236885 A/G cg14352298 chr13:112236639 NA 0.29 6.74 0.35 7.32e-11 Hepatitis; CRC cis rs28386778 0.897 rs2854221 chr17:61941445 G/T cg25654072 chr17:61904446 PSMC5;FTSJ3 0.69 10.69 0.51 4.27e-23 Prudent dietary pattern; CRC cis rs6088580 0.634 rs6058052 chr20:33047084 A/G cg08999081 chr20:33150536 PIGU 0.61 11.3 0.53 3.09e-25 Glomerular filtration rate (creatinine); CRC cis rs12142240 0.698 rs12385695 chr1:46819021 A/G cg00530320 chr1:46809349 NSUN4 0.58 7.93 0.4 3.43e-14 Menopause (age at onset); CRC cis rs4073582 0.595 rs801736 chr11:65928430 A/T cg14036092 chr11:66035641 RAB1B 0.54 8.74 0.43 1.24e-16 Gout; CRC cis rs7481584 0.624 rs438384 chr11:3045651 A/G cg25174290 chr11:3078921 CARS -0.4 -5.65 -0.3 3.49e-8 Calcium levels; CRC cis rs7584330 0.518 rs74003108 chr2:238448000 T/C cg08992911 chr2:238395768 MLPH 0.61 6.18 0.32 1.91e-9 Prostate cancer; CRC cis rs7309 0.935 rs1921309 chr2:162048975 T/A cg08807892 chr2:162101083 NA 0.46 6.7 0.35 9.01e-11 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Educational attainment; CRC cis rs67478160 0.704 rs12894254 chr14:104290949 G/C cg01849466 chr14:104193079 ZFYVE21 -0.47 -8.31 -0.42 2.52e-15 Schizophrenia; CRC cis rs780096 0.526 rs780102 chr2:27659491 T/C cg17158414 chr2:27665306 KRTCAP3 -0.31 -6.75 -0.35 6.85e-11 Total body bone mineral density; CRC trans rs4927850 1.000 rs4927850 chr3:195751630 C/T cg16724585 chr3:197361211 NA 0.47 6.95 0.36 1.92e-11 Pancreatic cancer; CRC cis rs11190604 1.000 rs74210981 chr10:102287520 C/T cg16342193 chr10:102329863 NA -0.4 -6.43 -0.33 4.55e-10 Palmitoleic acid (16:1n-7) levels; CRC cis rs67311347 0.544 rs67533651 chr3:40338367 T/A cg09455208 chr3:40491958 NA 0.31 6.31 0.33 8.76e-10 Renal cell carcinoma; CRC cis rs853679 1.000 rs853694 chr6:28279100 A/T cg06470822 chr6:28175283 NA 0.63 6.5 0.34 2.93e-10 Depression; CRC cis rs875971 0.928 rs6970357 chr7:65968878 T/C cg12463550 chr7:65579703 CRCP 0.47 6.79 0.35 5.17e-11 Aortic root size; CRC cis rs4713118 0.868 rs760587 chr6:27740300 C/A cg15845792 chr6:28175446 NA 0.7 7.72 0.39 1.43e-13 Parkinson's disease; CRC cis rs7937682 0.632 rs11823089 chr11:111673539 A/G cg19812747 chr11:111475976 SIK2 0.44 6.43 0.33 4.54e-10 Primary sclerosing cholangitis; CRC cis rs12545109 0.800 rs1992122 chr8:57409467 A/G cg09654669 chr8:57350985 NA -0.47 -7.57 -0.39 3.78e-13 Obesity-related traits; CRC cis rs2404602 0.735 rs2468130 chr15:76796496 T/C cg23625390 chr15:77176239 SCAPER -0.72 -11.02 -0.52 2.9e-24 Blood metabolite levels; CRC cis rs9811920 0.609 rs4479633 chr3:99654510 G/A cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G -0.46 -6.18 -0.32 1.87e-9 Axial length; CRC cis rs6479527 0.904 rs10739969 chr9:96866877 C/T cg14459158 chr9:96720562 NA -0.4 -6.86 -0.35 3.49e-11 Esophageal adenocarcinoma; CRC cis rs2576037 0.526 rs9962523 chr18:44486414 A/T cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.67 -10.86 -0.51 1.11e-23 Personality dimensions; CRC cis rs9910055 0.607 rs13726 chr17:42239561 C/T cg10896456 chr17:42255109 ASB16;C17orf65 0.44 7.24 0.37 3.25e-12 Total body bone mineral density; CRC cis rs1580019 0.922 rs59938271 chr7:32484844 T/C cg07520158 chr7:32535189 LSM5;AVL9 0.49 6.53 0.34 2.46e-10 Cognitive ability; CRC cis rs4862750 0.872 rs4862747 chr4:187877236 A/T cg11301795 chr4:187892539 NA 0.84 19.23 0.73 8.89e-56 Lobe attachment (rater-scored or self-reported); CRC cis rs10504229 0.683 rs16921808 chr8:58106049 C/T cg22535103 chr8:58192502 C8orf71 -0.71 -8.84 -0.44 5.82e-17 Developmental language disorder (linguistic errors); CRC cis rs3219474 0.502 rs41343546 chr1:45908263 A/G cg06784218 chr1:46089804 CCDC17 0.7 6.94 0.36 2.14e-11 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs875971 1.000 rs1183245 chr7:65541185 C/T cg18912574 chr7:65842487 NCRNA00174 -0.37 -6.32 -0.33 8.29e-10 Aortic root size; CRC cis rs9468186 1 rs9468186 chr6:27626631 A/G cg02683197 chr6:28174875 NA 0.48 5.75 0.3 2.09e-8 Neuroticism; CRC cis rs12431939 0.671 rs2999384 chr14:51650328 G/T cg23942311 chr14:51606299 NA 0.51 7.1 0.36 7.85e-12 Cancer; CRC cis rs7586879 0.765 rs10171663 chr2:25086431 T/C cg04586622 chr2:25135609 ADCY3 -0.49 -8.36 -0.42 1.74e-15 Body mass index; CRC cis rs6540559 0.605 rs3753518 chr1:209977964 G/C cg23283495 chr1:209979779 IRF6 0.49 6.88 0.35 3.03e-11 Cleft lip with or without cleft palate; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg02604819 chr2:70418301 C2orf42 0.46 6.48 0.34 3.37e-10 Response to antipsychotic treatment; CRC cis rs1555322 0.530 rs932562 chr20:33871310 T/C cg13662093 chr20:33865505 NA 0.43 6.03 0.32 4.34e-9 Attention deficit hyperactivity disorder; CRC cis rs11098499 0.954 rs3733520 chr4:120423480 C/G cg24375607 chr4:120327624 NA 0.49 7.46 0.38 7.64e-13 Corneal astigmatism; CRC cis rs7300001 0.667 rs7298716 chr12:110506181 A/T cg12870014 chr12:110450643 ANKRD13A 0.94 9.82 0.48 3.97e-20 Headache; CRC cis rs9926296 0.572 rs8046872 chr16:89841552 T/C cg04287289 chr16:89883240 FANCA 0.57 9.1 0.45 8.64e-18 Vitiligo; CRC cis rs7727544 0.735 rs274559 chr5:131720070 A/G cg11843238 chr5:131593191 PDLIM4 -0.33 -6.23 -0.32 1.46e-9 Blood metabolite levels; CRC trans rs7618501 0.699 rs9821675 chr3:49902544 A/G cg21665057 chr3:196295764 WDR53;FBXO45 0.66 10.39 0.5 4.66e-22 Intelligence (multi-trait analysis); CRC cis rs7937682 0.921 rs11213945 chr11:111461003 A/G cg19812747 chr11:111475976 SIK2 0.52 7.5 0.38 6.11e-13 Primary sclerosing cholangitis; CRC cis rs853679 0.517 rs56364346 chr6:28050762 T/G cg23161317 chr6:28129485 ZNF389 0.51 6.36 0.33 6.66e-10 Depression; CRC cis rs13108904 0.901 rs2293634 chr4:1291711 T/G cg20887711 chr4:1340912 KIAA1530 0.46 6.78 0.35 5.45e-11 Obesity-related traits; CRC cis rs17234274 0.622 rs984613 chr11:23235665 T/C cg05245346 chr11:23248277 NA 0.34 5.62 0.3 4.17e-8 Cancer; CRC cis rs12369635 1.000 rs12372807 chr12:129561332 C/T cg01909103 chr12:129572610 TMEM132D -0.74 -7.05 -0.36 1.04e-11 Schizophrenia (inflammation and infection response interaction); CRC cis rs2289583 0.573 rs8025880 chr15:75394881 G/C cg14664628 chr15:75095509 CSK 0.44 6.13 0.32 2.5e-9 Systemic lupus erythematosus; CRC cis rs7769051 1.000 rs12204027 chr6:133122831 A/G cg07930552 chr6:133119739 C6orf192 0.72 8.67 0.43 1.96e-16 Type 2 diabetes nephropathy; CRC cis rs10751667 0.643 rs10902244 chr11:949981 A/G ch.11.42038R chr11:967971 AP2A2 0.59 10.18 0.49 2.44e-21 Alzheimer's disease (late onset); CRC cis rs12971120 0.891 rs4891558 chr18:72170359 A/G cg25817165 chr18:72167213 CNDP2 -0.6 -7.95 -0.4 3.08e-14 Refractive error; CRC cis rs12973672 0.904 rs12974791 chr19:35767218 A/G cg12095397 chr19:35769544 USF2 0.43 5.67 0.3 3.1e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs56114371 0.777 rs200482 chr6:27773904 G/A cg06470822 chr6:28175283 NA 0.67 5.79 0.3 1.66e-8 Breast cancer; CRC cis rs17270561 0.609 rs1165156 chr6:25792978 T/C cg17691542 chr6:26056736 HIST1H1C 0.52 7.09 0.36 8.45e-12 Iron status biomarkers; CRC cis rs7635838 0.785 rs2606738 chr3:11396562 T/C cg00170343 chr3:11313890 ATG7 0.44 6.57 0.34 1.94e-10 HDL cholesterol; CRC cis rs7811142 1.000 rs2897358 chr7:100088640 C/G cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.61 7.84 0.4 6.18e-14 Platelet count; CRC cis rs4713118 0.911 rs2394000 chr6:27686991 A/G cg02683197 chr6:28174875 NA 0.57 7.29 0.37 2.33e-12 Parkinson's disease; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg01579706 chr4:83821883 THAP9 0.37 5.96 0.31 6.46e-9 Liver disease severity in Alagille syndrome; CRC cis rs10791097 0.694 rs2155752 chr11:130755998 C/T cg12179176 chr11:130786555 SNX19 0.75 12.45 0.57 2e-29 Autism spectrum disorder or schizophrenia;Schizophrenia; CRC cis rs8044868 0.541 rs7202268 chr16:72086746 A/G cg23815491 chr16:72088622 HP 0.5 7.32 0.37 1.87e-12 Body mass index (change over time) in cancer or chronic obstructive pulmonary disease;Body mass index (change over time) in cancer; CRC cis rs13088281 1.000 rs13088281 chr3:53147576 A/C cg07884673 chr3:53033167 SFMBT1 -0.75 -5.86 -0.31 1.14e-8 Immune reponse to smallpox (secreted IL-2); CRC cis rs6500395 0.926 rs8057777 chr16:48565643 T/C cg04672837 chr16:48644449 N4BP1 0.4 5.8 0.3 1.56e-8 Response to tocilizumab in rheumatoid arthritis; CRC cis rs9649213 0.593 rs6947340 chr7:97912241 A/G cg24562669 chr7:97807699 LMTK2 -0.45 -7.71 -0.39 1.53e-13 Prostate cancer (SNP x SNP interaction); CRC cis rs6066835 1.000 rs6066835 chr20:47355009 A/G cg18078177 chr20:47281410 PREX1 0.55 5.66 0.3 3.24e-8 Multiple myeloma; CRC cis rs9894429 0.966 rs6565605 chr17:79589359 C/T cg21028142 chr17:79581711 NPLOC4 0.39 8.51 0.42 6.46e-16 Eye color traits; CRC trans rs9354308 0.901 rs2814096 chr6:66566131 G/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.47 5.98 0.31 5.9e-9 Metabolite levels; CRC cis rs11190604 1.000 rs2295770 chr10:102239829 G/A cg16342193 chr10:102329863 NA -0.36 -5.91 -0.31 8.56e-9 Palmitoleic acid (16:1n-7) levels; CRC cis rs8044995 0.563 rs57434514 chr16:68402649 G/A cg09835421 chr16:68378352 PRMT7 -0.77 -7.62 -0.39 2.73e-13 Schizophrenia; CRC cis rs4733770 0.581 rs12550366 chr8:131136047 A/T cg26053073 chr8:131455383 NA -0.35 -5.63 -0.3 3.84e-8 Schizophrenia; CRC cis rs9783347 0.925 rs3825025 chr11:18343822 C/G cg15585147 chr11:18324498 HPS5 0.45 6.34 0.33 7.44e-10 Pancreatic cancer; CRC cis rs4974559 0.739 rs4333131 chr4:1323789 A/G cg02980000 chr4:1222292 CTBP1 0.5 6.36 0.33 6.68e-10 Systolic blood pressure; CRC cis rs13256369 1.000 rs13282915 chr8:8570891 T/G cg17143192 chr8:8559678 CLDN23 0.48 6.35 0.33 7.08e-10 Obesity-related traits; CRC cis rs1419980 0.673 rs4883421 chr12:7774028 A/G cg10578777 chr12:7781093 NA 0.46 6.14 0.32 2.42e-9 HDL cholesterol levels; CRC trans rs10842750 1.000 rs10842750 chr12:26690565 G/T cg10477989 chr11:68039601 C11orf24 0.51 6.0 0.31 5.15e-9 Kashin-Beck disease; CRC cis rs4601821 0.522 rs754672 chr11:113249136 C/T cg14159747 chr11:113255604 NA 0.57 11.17 0.52 8.58e-25 Alcoholic chronic pancreatitis; CRC cis rs798554 0.660 rs2644295 chr7:2860217 A/C cg19717773 chr7:2847554 GNA12 -0.47 -7.98 -0.4 2.38e-14 Height; CRC trans rs2727020 0.554 rs2866490 chr11:49425463 A/G cg15704280 chr7:45808275 SEPT13 -0.73 -9.21 -0.45 3.84e-18 Coronary artery disease; CRC cis rs4731207 0.596 rs7794959 chr7:124649139 C/T cg23710748 chr7:124431027 NA -0.39 -6.24 -0.33 1.35e-9 Cutaneous malignant melanoma; CRC cis rs12956009 0.518 rs10164267 chr18:44820032 C/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 -0.37 -5.76 -0.3 1.89e-8 Educational attainment (years of education); CRC cis rs9916302 0.595 rs4795371 chr17:37636695 T/G cg07936489 chr17:37558343 FBXL20 -0.84 -12.93 -0.58 3.44e-31 Glomerular filtration rate (creatinine); CRC cis rs9916302 0.660 rs665413 chr17:37455678 T/A cg00129232 chr17:37814104 STARD3 0.58 7.22 0.37 3.68e-12 Glomerular filtration rate (creatinine); CRC cis rs4925386 0.959 rs4925385 chr20:60920624 A/G cg24112000 chr20:60950667 NA 0.51 8.9 0.44 3.7e-17 Colorectal cancer;Colorectal cancer (SNP x SNP interaction); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg00857557 chr6:42982050 MEA1;KLHDC3 0.38 6.39 0.33 5.62e-10 Liver disease severity in Alagille syndrome; CRC cis rs9297145 1.000 rs9297145 chr7:98759117 A/C cg05967295 chr7:98741636 SMURF1 1.01 17.72 0.7 8.74e-50 Crohn's disease;Inflammatory bowel disease;Ulcerative colitis; CRC cis rs2243480 0.901 rs313808 chr7:65499873 T/G cg25985355 chr7:65971099 NA -0.5 -5.76 -0.3 1.88e-8 Diabetic kidney disease; CRC cis rs11098499 0.566 rs7664440 chr4:120578540 A/G cg09307838 chr4:120376055 NA 0.66 9.72 0.47 8.22e-20 Corneal astigmatism; CRC cis rs10416265 0.527 rs7246814 chr19:33538414 G/T cg17764715 chr19:33622953 WDR88 0.44 6.57 0.34 2e-10 Bone properties (heel); CRC cis rs734999 0.505 rs4073285 chr1:2539796 C/T cg20673091 chr1:2541236 MMEL1 0.35 5.61 0.3 4.26e-8 Ulcerative colitis; CRC cis rs7264396 0.512 rs2425072 chr20:34293686 T/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.47 -6.41 -0.33 5e-10 Total cholesterol levels; CRC cis rs7940866 0.817 rs961491 chr11:130866090 G/T cg12179176 chr11:130786555 SNX19 0.56 8.22 0.41 4.78e-15 Schizophrenia; CRC cis rs10504229 0.679 rs6995378 chr8:58113933 C/T cg21724239 chr8:58056113 NA 0.49 6.77 0.35 5.94e-11 Developmental language disorder (linguistic errors); CRC cis rs524023 0.914 rs4930556 chr11:64377726 G/C cg06522879 chr11:64358276 SLC22A12 -0.53 -8.32 -0.42 2.36e-15 Urate levels in obese individuals; CRC cis rs6502050 0.769 rs9904237 chr17:80119664 G/A cg11859384 chr17:80120422 CCDC57 -0.36 -5.75 -0.3 2.06e-8 Life satisfaction; CRC cis rs3796352 1.000 rs58660500 chr3:53086573 C/T cg06204229 chr3:52865917 ITIH4 0.5 5.93 0.31 7.74e-9 Immune reponse to smallpox (secreted IL-2); CRC cis rs1799949 1.000 rs12950607 chr17:41299928 G/C cg25072359 chr17:41440525 NA 0.46 6.97 0.36 1.79e-11 Menopause (age at onset); CRC cis rs9814567 1.000 rs9869981 chr3:134248801 C/T cg06541857 chr3:134203789 ANAPC13;CEP63 -0.4 -6.12 -0.32 2.65e-9 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs4713118 0.513 rs149959 chr6:28013854 T/C cg02683197 chr6:28174875 NA 0.62 8.5 0.42 6.57e-16 Parkinson's disease; CRC cis rs11971779 0.680 rs7801613 chr7:139039927 A/G cg07862535 chr7:139043722 LUC7L2 -0.57 -7.23 -0.37 3.51e-12 Diisocyanate-induced asthma; CRC cis rs2033711 0.870 rs11084545 chr19:58951693 G/C cg13877915 chr19:58951672 ZNF132 0.51 8.22 0.41 4.86e-15 Uric acid clearance; CRC cis rs2204008 0.571 rs7970136 chr12:38531951 G/C cg13010199 chr12:38710504 ALG10B -0.42 -6.05 -0.32 3.97e-9 Bladder cancer; CRC trans rs116095464 0.558 rs10462754 chr5:246669 T/C cg00938859 chr5:1591904 SDHAP3 0.73 7.76 0.39 1.07e-13 Breast cancer; CRC cis rs262150 0.837 rs2657404 chr7:158783155 C/T cg12590608 chr7:158785262 NA 0.47 8.72 0.43 1.43e-16 Facial morphology (factor 20); CRC cis rs7312774 0.618 rs57361179 chr12:107337483 T/C cg16260113 chr12:107380972 MTERFD3 0.78 7.97 0.4 2.72e-14 Severe influenza A (H1N1) infection; CRC cis rs7312933 0.558 rs1669936 chr12:42813509 C/A cg19980929 chr12:42632907 YAF2 -0.4 -6.19 -0.32 1.82e-9 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CRC cis rs17767392 0.781 rs34388001 chr14:71883500 A/G cg13720639 chr14:72061746 SIPA1L1 -0.49 -6.27 -0.33 1.13e-9 Mitral valve prolapse; CRC cis rs9583531 0.527 rs6492302 chr13:111352354 C/T cg24331049 chr13:111365604 ING1 -0.57 -8.06 -0.41 1.4e-14 Coronary artery disease; CRC cis rs1784581 0.588 rs6415086 chr6:162418147 C/T cg17173639 chr6:162384350 PARK2 0.6 9.72 0.47 8.36e-20 Itch intensity from mosquito bite; CRC cis rs17376456 0.569 rs896729 chr5:93222178 A/G cg25358565 chr5:93447407 FAM172A -0.67 -7.83 -0.4 6.88e-14 Diabetic retinopathy; CRC cis rs2070488 0.965 rs4679053 chr3:38523495 G/T cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.92 17.37 0.69 2.09e-48 Electrocardiographic conduction measures; CRC trans rs66573146 0.656 rs66517061 chr4:6935163 C/G cg07817883 chr1:32538562 TMEM39B 1.34 12.55 0.57 8.9e-30 Granulocyte percentage of myeloid white cells; CRC cis rs2252790 0.899 rs2501052 chr6:116658955 A/G cg18764771 chr6:116381957 FRK -0.22 -5.94 -0.31 7.42e-9 Fast beta electroencephalogram; CRC cis rs4727027 0.899 rs11768971 chr7:148825826 C/G cg12479418 chr7:148823350 ZNF425;ZNF398 0.44 5.88 0.31 1e-8 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC cis rs2228479 0.702 rs12600151 chr16:89831558 C/T cg06656553 chr16:89960601 TCF25 -0.7 -5.84 -0.31 1.23e-8 Skin colour saturation; CRC cis rs6570726 0.935 rs453609 chr6:145812332 T/C cg05347473 chr6:146136440 FBXO30 0.37 5.88 0.31 9.83e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs4664293 1.000 rs12692554 chr2:160451288 G/A cg08347373 chr2:160653686 CD302 -0.37 -6.03 -0.32 4.29e-9 Monocyte percentage of white cells; CRC cis rs57221529 0.709 rs111352378 chr5:577079 G/A cg16447950 chr5:562315 NA -0.83 -10.81 -0.51 1.71e-23 Lung disease severity in cystic fibrosis; CRC cis rs801193 0.660 rs1962050 chr7:66240008 C/T cg00343986 chr7:65444356 GUSB -0.43 -6.12 -0.32 2.66e-9 Aortic root size; CRC cis rs2455601 0.882 rs11042115 chr11:8926679 A/C cg09997546 chr11:8931473 C11orf17;ST5 -0.51 -6.72 -0.35 8.25e-11 Schizophrenia; CRC cis rs6541297 1.000 rs4846836 chr1:230281316 G/A cg05784532 chr1:230284198 GALNT2 0.47 6.45 0.33 4.09e-10 Coronary artery disease; CRC cis rs9649213 0.574 rs62479853 chr7:97917158 G/T cg21770322 chr7:97807741 LMTK2 0.55 9.29 0.46 2.16e-18 Prostate cancer (SNP x SNP interaction); CRC cis rs6951245 1.000 rs80094748 chr7:1103958 G/A cg03188948 chr7:1209495 NA 0.65 6.81 0.35 4.74e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs9303280 0.773 rs4795397 chr17:38023745 A/G cg17344932 chr17:38183730 MED24;SNORD124 0.36 5.78 0.3 1.76e-8 Self-reported allergy; CRC cis rs2243480 0.901 rs2949697 chr7:65464236 A/G cg12463550 chr7:65579703 CRCP 0.65 6.2 0.32 1.67e-9 Diabetic kidney disease; CRC cis rs524281 0.773 rs10791861 chr11:66008470 G/A cg16950941 chr11:66035639 RAB1B -0.7 -8.04 -0.41 1.67e-14 Electroencephalogram traits; CRC cis rs9303280 0.901 rs921650 chr17:38069076 G/A cg11212589 chr17:38028394 ZPBP2 -0.44 -8.02 -0.4 1.89e-14 Self-reported allergy; CRC cis rs10782582 0.586 rs112368938 chr1:76336339 C/T cg03433033 chr1:76189801 ACADM -0.41 -5.84 -0.31 1.29e-8 Daytime sleep phenotypes; CRC cis rs11009175 0.556 rs11009173 chr10:33292325 A/G cg00146027 chr10:33299147 NA 0.24 5.68 0.3 2.96e-8 Depression (quantitative trait); CRC cis rs4332037 0.506 rs62442924 chr7:1989976 C/T cg02421172 chr7:1938701 MAD1L1 0.42 5.73 0.3 2.26e-8 Bipolar disorder; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg10292851 chr8:101572103 ANKRD46 0.44 6.3 0.33 9.32e-10 Intelligence (multi-trait analysis); CRC cis rs7119 0.717 rs12901732 chr15:77818933 G/T cg10437265 chr15:77819839 NA 0.7 12.76 0.58 1.43e-30 Type 2 diabetes; CRC cis rs12681288 0.963 rs7822955 chr8:1029090 C/T cg04851639 chr8:1020857 NA 0.32 6.47 0.34 3.62e-10 Schizophrenia; CRC cis rs4132462 0.888 rs62182999 chr2:212605745 T/C cg15635483 chr2:212618994 ERBB4 -0.4 -5.8 -0.3 1.58e-8 Intelligence (multi-trait analysis); CRC trans rs8035957 1.000 rs4924273 chr15:38846738 C/G cg01402409 chr4:78978133 FRAS1 -0.51 -6.15 -0.32 2.28e-9 Type 1 diabetes; CRC cis rs12325245 0.536 rs3169293 chr16:58552959 A/G cg02549819 chr16:58548995 SETD6 1.2 7.85 0.4 5.77e-14 Schizophrenia; CRC cis rs2404602 0.692 rs8024476 chr15:76983954 T/C cg03037974 chr15:76606532 NA 0.68 11.83 0.55 3.67e-27 Blood metabolite levels; CRC trans rs2727020 0.619 rs1829979 chr11:49436875 T/G cg03929089 chr4:120376271 NA -0.72 -9.13 -0.45 7.04e-18 Coronary artery disease; CRC cis rs6748734 0.625 rs4312489 chr2:241821068 T/A cg16358738 chr2:241808595 AGXT -0.41 -7.21 -0.37 3.8e-12 Urinary metabolites; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg21515243 chr18:21033072 RIOK3 0.48 7.13 0.37 6.61e-12 Response to antipsychotic treatment; CRC cis rs526821 0.595 rs499446 chr11:55355722 A/G cg04317927 chr11:55418816 OR4S2 0.39 6.64 0.34 1.28e-10 Pediatric bone mineral density (spine); CRC cis rs6952808 0.929 rs12532128 chr7:1925454 T/C cg00106254 chr7:1943704 MAD1L1 -0.51 -7.65 -0.39 2.2e-13 Bipolar disorder and schizophrenia; CRC cis rs4743820 0.603 rs7045740 chr9:93926650 A/G cg14446406 chr9:93919335 NA 0.4 6.84 0.35 3.9e-11 Ulcerative colitis;Inflammatory bowel disease; CRC cis rs9747201 0.962 rs62079995 chr17:80076624 C/T cg09264619 chr17:80180166 NA 0.53 7.69 0.39 1.72e-13 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs6502050 0.835 rs10163485 chr17:80110750 C/T cg13198984 chr17:80129470 CCDC57 0.46 8.16 0.41 6.94e-15 Life satisfaction; CRC cis rs9491140 0.539 rs10872287 chr6:124694573 T/G cg19267163 chr6:125004984 NKAIN2 0.54 6.65 0.34 1.22e-10 Neuroticism; CRC cis rs2066819 1.000 rs79436528 chr12:56686997 C/T cg26714650 chr12:56694279 CS -1.41 -11.64 -0.54 1.88e-26 Psoriasis vulgaris; CRC cis rs10256972 0.552 rs6978842 chr7:1204599 A/C cg23978390 chr7:1156363 C7orf50 0.42 5.75 0.3 2.09e-8 Longevity;Endometriosis; CRC trans rs13046373 0.905 rs4816372 chr21:32077414 A/T cg03133777 chr2:170361364 BBS5 -0.43 -6.65 -0.34 1.19e-10 HDL cholesterol; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg00320645 chr10:72163720 EIF4EBP2 0.49 6.44 0.33 4.29e-10 Anxiety disorder; CRC trans rs9388451 0.839 rs9321054 chr6:126079968 A/G cg05039488 chr6:79577232 IRAK1BP1 0.55 8.6 0.43 3.31e-16 Brugada syndrome; CRC cis rs6499255 1.000 rs4580150 chr16:69814953 G/A cg04110750 chr16:69646130 NFAT5 -0.53 -6.98 -0.36 1.63e-11 IgE levels; CRC trans rs7726839 0.561 rs72703046 chr5:580129 T/C cg25482853 chr8:67687455 SGK3 1.01 12.23 0.56 1.28e-28 Obesity-related traits; CRC cis rs1707322 0.691 rs61784803 chr1:46179271 C/A cg06784218 chr1:46089804 CCDC17 -0.66 -12.27 -0.56 9.04e-29 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs3733585 0.699 rs7683283 chr4:9969974 T/C cg11266682 chr4:10021025 SLC2A9 -0.46 -9.34 -0.46 1.55e-18 Cleft plate (environmental tobacco smoke interaction); CRC cis rs1046896 1.000 rs1046875 chr17:80685426 A/G cg19500275 chr17:80737654 TBCD -0.4 -6.04 -0.32 4.19e-9 Glycated hemoglobin levels; CRC cis rs7412746 0.634 rs2124952 chr1:150923774 T/A cg10589385 chr1:150898437 SETDB1 0.32 6.83 0.35 4.05e-11 Melanoma; CRC cis rs11252926 0.599 rs11252213 chr10:454694 C/T cg18196295 chr10:418757 DIP2C 0.51 8.09 0.41 1.19e-14 Psychosis in Alzheimer's disease; CRC cis rs9391253 0.571 rs314281 chr6:105400605 T/C cg02098413 chr6:105308735 HACE1 0.31 5.62 0.3 4.03e-8 Height;Age at voice drop;Puberty onset (breast development); CRC cis rs780096 0.526 rs4582 chr2:27604279 A/G cg22903471 chr2:27725779 GCKR -0.37 -5.99 -0.31 5.52e-9 Total body bone mineral density; CRC cis rs12666575 0.504 rs10226475 chr7:2226162 A/G cg02951883 chr7:2050386 MAD1L1 -0.49 -7.22 -0.37 3.73e-12 Schizophrenia; CRC cis rs62064224 0.554 rs9889352 chr17:30775761 T/C cg18200150 chr17:30822561 MYO1D 0.49 9.7 0.47 1.01e-19 Schizophrenia; CRC cis rs6582630 0.555 rs1906260 chr12:38601013 T/G cg13010199 chr12:38710504 ALG10B 0.45 5.7 0.3 2.72e-8 Drug-induced liver injury (flucloxacillin); CRC cis rs3820068 0.581 rs72645881 chr1:15928203 C/T cg27534772 chr1:16042836 PLEKHM2 0.54 10.46 0.5 2.7e-22 Systolic blood pressure; CRC cis rs12908161 1.000 rs62021219 chr15:85256159 C/T cg11189052 chr15:85197271 WDR73 0.61 8.88 0.44 4.41e-17 Schizophrenia; CRC cis rs28386778 0.863 rs2597633 chr17:61872871 T/C cg06873352 chr17:61820015 STRADA 0.77 14.5 0.62 3.45e-37 Prudent dietary pattern; CRC cis rs10504229 0.906 rs72650894 chr8:58179734 C/T cg01721255 chr8:58191610 C8orf71 0.49 6.17 0.32 2e-9 Developmental language disorder (linguistic errors); CRC cis rs9311474 0.539 rs12489828 chr3:52567014 G/T cg11645453 chr3:52864694 ITIH4 0.35 6.65 0.34 1.26e-10 Electroencephalogram traits; CRC trans rs11098499 0.754 rs11732087 chr4:120239831 A/G cg25214090 chr10:38739885 LOC399744 0.53 8.45 0.42 9.68e-16 Corneal astigmatism; CRC cis rs9649213 0.593 rs35941058 chr7:97918159 T/C cg24562669 chr7:97807699 LMTK2 0.45 7.54 0.38 4.56e-13 Prostate cancer (SNP x SNP interaction); CRC trans rs561341 1.000 rs72825712 chr17:30316119 A/T cg20587970 chr11:113659929 NA -1.42 -20.29 -0.75 6.11e-60 Hip circumference adjusted for BMI; CRC cis rs9322193 0.923 rs9479494 chr6:150060244 A/G cg00933542 chr6:150070202 PCMT1 0.34 7.04 0.36 1.12e-11 Lung cancer; CRC cis rs7635838 0.718 rs2248971 chr3:11403441 T/C cg00170343 chr3:11313890 ATG7 0.47 7.25 0.37 2.95e-12 HDL cholesterol; CRC cis rs11098499 0.866 rs7665125 chr4:120402079 G/T cg09307838 chr4:120376055 NA 0.69 10.92 0.52 6.64e-24 Corneal astigmatism; CRC cis rs7605827 0.930 rs3805102 chr2:15518312 G/A cg19274914 chr2:15703543 NA 0.38 5.66 0.3 3.29e-8 Educational attainment (years of education); CRC cis rs4713675 0.546 rs10947430 chr6:33658534 G/A cg14003231 chr6:33640908 ITPR3 0.55 8.73 0.43 1.3e-16 Plateletcrit; CRC cis rs6460942 1.000 rs73053527 chr7:12313008 C/A cg06484146 chr7:12443880 VWDE -0.76 -7.47 -0.38 7.06e-13 Coronary artery disease; CRC cis rs1799949 1.000 rs12936831 chr17:41331816 C/T cg19454999 chr17:41278357 BRCA1;NBR2 0.53 8.28 0.42 3.22e-15 Menopause (age at onset); CRC cis rs875971 0.862 rs9791713 chr7:66105198 C/A cg11764359 chr7:65958608 NA -0.59 -8.78 -0.44 8.99e-17 Aortic root size; CRC trans rs5756813 0.754 rs762982 chr22:38144235 A/G cg19894588 chr14:64061835 NA 0.57 7.74 0.39 1.25e-13 Optic cup area;Vertical cup-disc ratio; CRC cis rs7945705 0.935 rs2568061 chr11:8886260 A/G cg21881798 chr11:8931708 C11orf17;ST5 -0.75 -12.73 -0.57 1.93e-30 Hemoglobin concentration; CRC cis rs4077515 0.504 rs7628 chr9:139318071 A/G cg14169450 chr9:139327907 INPP5E 0.36 5.94 0.31 7.44e-9 Ulcerative colitis;IgA nephropathy;Inflammatory bowel disease;Crohn's disease; CRC cis rs4654899 0.865 rs6700459 chr1:21279396 T/C cg02927042 chr1:21476669 EIF4G3 -0.51 -8.07 -0.41 1.37e-14 Superior frontal gyrus grey matter volume; CRC cis rs1552244 0.608 rs3732962 chr3:10048951 T/C cg00166722 chr3:10149974 C3orf24 0.43 6.37 0.33 6.36e-10 Alzheimer's disease; CRC trans rs7267979 0.844 rs6107017 chr20:25232300 A/G cg17903999 chr18:56338584 MALT1 -0.41 -6.57 -0.34 1.95e-10 Liver enzyme levels (alkaline phosphatase); CRC cis rs939584 1.000 rs6719883 chr2:651482 T/G cg03610516 chr2:642275 NA -0.43 -5.94 -0.31 7.19e-9 Body mass index; CRC cis rs875971 1.000 rs2420820 chr7:66091907 T/C cg18876405 chr7:65276391 NA -0.52 -8.62 -0.43 2.82e-16 Aortic root size; CRC cis rs73206853 0.764 rs60027620 chr12:111103669 T/G cg12870014 chr12:110450643 ANKRD13A 0.87 10.08 0.49 5.28e-21 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC cis rs1552172 1.000 rs1552172 chr1:145704759 T/A cg11743829 chr1:145714124 CD160 -0.41 -6.09 -0.32 3.13e-9 Breast cancer; CRC cis rs698833 0.852 rs698768 chr2:44576549 C/T cg04920474 chr2:44395004 PPM1B 0.41 6.13 0.32 2.54e-9 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; CRC cis rs6582630 0.519 rs8189599 chr12:38280748 A/G cg26384229 chr12:38710491 ALG10B 0.68 9.2 0.45 4.14e-18 Drug-induced liver injury (flucloxacillin); CRC cis rs4713118 0.587 rs9393899 chr6:28133528 G/C cg12273811 chr6:28175739 NA 0.73 9.16 0.45 5.8e-18 Parkinson's disease; CRC cis rs9322193 0.923 rs7740278 chr6:149961252 C/T cg05861140 chr6:150128134 PCMT1 -0.36 -5.92 -0.31 8.26e-9 Lung cancer; CRC trans rs2303319 0.582 rs16845851 chr2:162295623 A/C cg19471553 chr17:41393123 NA -0.72 -6.22 -0.32 1.53e-9 Cognitive function; CRC cis rs6088590 1.000 rs10048849 chr20:33419680 C/T cg08999081 chr20:33150536 PIGU 0.51 8.55 0.43 4.75e-16 Coronary artery disease; CRC cis rs9311474 0.607 rs4687625 chr3:52563718 C/T cg07507251 chr3:52567010 NT5DC2 0.49 7.36 0.38 1.47e-12 Electroencephalogram traits; CRC cis rs1572438 0.868 rs1577625 chr6:860044 C/A cg21062780 chr6:887772 NA -0.35 -5.72 -0.3 2.39e-8 Aging; CRC cis rs6752107 0.967 rs3816234 chr2:234185999 G/A cg07618928 chr2:234183455 ATG16L1;SCARNA5 0.66 11.5 0.54 5.74e-26 Crohn's disease;Inflammatory bowel disease; CRC cis rs968567 0.817 rs61896141 chr11:61556039 A/C cg19610905 chr11:61596333 FADS2 -0.65 -8.13 -0.41 8.86e-15 Blood metabolite levels;Rheumatoid arthritis;Vitiligo;Glycerophospholipid levels; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg10784414 chr3:48647031 UQCRC1 0.37 6.09 0.32 3.13e-9 Liver disease severity in Alagille syndrome; CRC cis rs10540 0.908 rs12792111 chr11:520921 G/C cg03934478 chr11:495069 RNH1 0.71 7.89 0.4 4.58e-14 Body mass index; CRC cis rs6582630 0.576 rs3900594 chr12:38272429 C/T cg26384229 chr12:38710491 ALG10B -0.51 -7.36 -0.38 1.46e-12 Drug-induced liver injury (flucloxacillin); CRC cis rs9467711 0.659 rs13216828 chr6:26373507 G/A cg14345882 chr6:26364793 BTN3A2 0.64 5.63 0.3 3.85e-8 Autism spectrum disorder or schizophrenia; CRC cis rs524281 0.773 rs2236652 chr11:66002681 G/A cg16950941 chr11:66035639 RAB1B -0.7 -8.04 -0.41 1.67e-14 Electroencephalogram traits; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg17199681 chr17:3540328 CTNS;SHPK 0.4 6.58 0.34 1.89e-10 Liver disease severity in Alagille syndrome; CRC cis rs2979489 0.891 rs2979498 chr8:30375251 T/A cg26383811 chr8:30366931 RBPMS -0.71 -10.39 -0.5 4.75e-22 Mean corpuscular hemoglobin;Plateletcrit;Neutrophil count;Granulocyte count;Sum basophil neutrophil counts;Mean corpuscular volume;Myeloid white cell count;Sum neutrophil eosinophil counts; CRC cis rs898097 0.607 rs2199111 chr17:80823203 A/G cg03160526 chr17:80928410 B3GNTL1 -0.46 -7.36 -0.38 1.46e-12 Breast cancer; CRC trans rs11026407 0.967 rs7127246 chr11:22060228 C/G cg26646896 chr5:158686746 NA -0.55 -6.12 -0.32 2.65e-9 Plasma thyroid-stimulating hormone levels; CRC cis rs61008539 0.893 rs11765528 chr7:861952 C/T cg05535760 chr7:792225 HEATR2 -0.44 -5.63 -0.3 3.89e-8 Perceived unattractiveness to mosquitoes; CRC cis rs1881797 0.527 rs78398999 chr1:247686970 G/A cg05639522 chr1:247681581 NA 0.56 6.07 0.32 3.48e-9 Acute lymphoblastic leukemia (childhood); CRC cis rs9556958 0.527 rs9517313 chr13:99105892 C/G cg07423050 chr13:99094983 FARP1 0.62 9.7 0.47 1.03e-19 Educational attainment (years of education); CRC cis rs7568458 0.684 rs1048739 chr2:85764968 T/G cg02493740 chr2:85810744 VAMP5 -0.54 -8.23 -0.41 4.52e-15 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); CRC cis rs17592366 0.517 rs7147621 chr14:35275704 G/A cg09327582 chr14:35236912 BAZ1A 0.45 6.08 0.32 3.37e-9 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells; CRC trans rs9858542 0.953 rs9814873 chr3:49454112 A/G cg21659725 chr3:3221576 CRBN -0.63 -8.65 -0.43 2.38e-16 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs6952808 0.630 rs4719443 chr7:2161099 A/G cg22963979 chr7:1858916 MAD1L1 -0.45 -6.32 -0.33 8.42e-10 Bipolar disorder and schizophrenia; CRC cis rs2624839 0.630 rs2624841 chr3:50198415 C/T cg05623727 chr3:50126028 RBM5 0.4 6.3 0.33 9.8e-10 Intelligence (multi-trait analysis); CRC cis rs12594515 0.506 rs74199860 chr15:45989190 C/T cg06207120 chr15:45996521 NA 0.32 7.81 0.4 7.61e-14 Waist circumference;Weight; CRC cis rs11098499 0.954 rs10017371 chr4:120293776 A/G cg24375607 chr4:120327624 NA 0.49 7.62 0.39 2.75e-13 Corneal astigmatism; CRC cis rs8177253 0.665 rs12493887 chr3:133440737 T/C cg01448562 chr3:133502909 NA -0.37 -6.05 -0.32 4e-9 Iron status biomarkers; CRC cis rs910316 0.967 rs4899551 chr14:75660246 C/G cg03030879 chr14:75389066 RPS6KL1 0.41 6.27 0.33 1.15e-9 Height; CRC cis rs172166 0.516 rs1225618 chr6:28129713 A/C cg25164649 chr6:28176230 NA 0.47 6.89 0.36 2.78e-11 Cardiac Troponin-T levels; CRC cis rs4665809 1.000 rs1470097 chr2:26312840 A/G cg27170947 chr2:26402098 FAM59B -0.47 -6.43 -0.33 4.55e-10 Gut microbiome composition (summer); CRC cis rs208520 1.000 rs208537 chr6:66963544 A/G cg07460842 chr6:66804631 NA -0.92 -11.45 -0.53 8.97e-26 Exhaled nitric oxide output; CRC cis rs243505 0.660 rs3807451 chr7:148538622 T/C cg09806900 chr7:148480153 CUL1 0.52 6.61 0.34 1.58e-10 Inflammatory bowel disease;Crohn's disease; CRC cis rs7208859 0.623 rs9915566 chr17:29132158 G/A cg01831904 chr17:28903510 LRRC37B2 -0.62 -6.41 -0.33 5.13e-10 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs1129187 0.755 rs7760250 chr6:42929839 G/A cg02359409 chr6:42947317 PEX6 -0.67 -11.15 -0.52 1.02e-24 Alzheimer's disease in APOE e4+ carriers; CRC cis rs2012796 0.956 rs10450940 chr14:81825326 C/A cg02996355 chr14:81879375 NA 0.51 7.61 0.39 2.89e-13 Night sleep phenotypes; CRC cis rs12410462 0.579 rs116423559 chr1:227575014 A/G cg23173402 chr1:227635558 NA 0.71 6.12 0.32 2.6e-9 Major depressive disorder; CRC trans rs1455244 0.700 rs7229302 chr18:11508904 G/T cg02987130 chr19:45927004 ERCC1 0.41 6.06 0.32 3.8e-9 Schizophrenia; CRC cis rs6988985 0.703 rs7833723 chr8:143925666 A/G cg10324643 chr8:143916377 GML 0.35 5.73 0.3 2.25e-8 Plasma androstenedione levels in resected early stage-receptor positive breast cancer; CRC cis rs2243480 1.000 rs316304 chr7:65616894 T/C cg12463550 chr7:65579703 CRCP 0.71 6.52 0.34 2.65e-10 Diabetic kidney disease; CRC cis rs1997103 1.000 rs2331065 chr7:55408392 A/G cg17469321 chr7:55412551 NA 0.72 11.28 0.53 3.48e-25 QRS interval (sulfonylurea treatment interaction); CRC cis rs8077889 1.000 rs4793035 chr17:41887753 C/T cg16892393 chr17:41919603 NA 0.57 8.01 0.4 1.97e-14 Triglycerides; CRC cis rs4722166 0.541 rs1800795 chr7:22766645 C/G cg26061582 chr7:22766209 IL6 0.52 8.09 0.41 1.15e-14 Lung cancer; CRC cis rs1451375 0.652 rs1470747 chr7:50627009 C/T cg14593290 chr7:50529359 DDC 0.59 7.85 0.4 5.95e-14 Malaria; CRC cis rs10751667 0.601 rs10902272 chr11:1040821 A/C ch.11.42038R chr11:967971 AP2A2 0.52 6.69 0.35 9.86e-11 Alzheimer's disease (late onset); CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg10488476 chr17:48133676 ITGA3 0.48 6.28 0.33 1.05e-9 Anxiety disorder; CRC cis rs10504229 0.728 rs17804750 chr8:58155751 T/C cg11062466 chr8:58055876 NA 0.45 6.11 0.32 2.74e-9 Developmental language disorder (linguistic errors); CRC cis rs910316 0.763 rs175014 chr14:75456927 A/G cg08847533 chr14:75593920 NEK9 -0.86 -14.84 -0.63 1.71e-38 Height; CRC cis rs4713118 0.586 rs6905516 chr6:28086478 A/G cg03623178 chr6:28175578 NA 0.95 12.17 0.56 2.13e-28 Parkinson's disease; CRC cis rs7647973 0.848 rs4292260 chr3:49148890 T/C cg20833759 chr3:49053208 WDR6;DALRD3 0.7 10.75 0.51 2.73e-23 Menarche (age at onset); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg03425219 chr11:18548609 TSG101 0.47 6.94 0.36 2.12e-11 Intelligence (multi-trait analysis); CRC cis rs10751667 0.714 rs7396700 chr11:963863 A/C cg01483505 chr11:975446 AP2A2 0.46 7.66 0.39 2.11e-13 Alzheimer's disease (late onset); CRC cis rs7216064 1.000 rs7223930 chr17:65842186 G/A cg12091567 chr17:66097778 LOC651250 -0.63 -7.95 -0.4 3.08e-14 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CRC cis rs10504229 0.679 rs7813252 chr8:58136389 C/G cg02725872 chr8:58115012 NA -0.63 -11.39 -0.53 1.41e-25 Developmental language disorder (linguistic errors); CRC cis rs7772486 0.727 rs6941429 chr6:145952283 G/A cg05347473 chr6:146136440 FBXO30 0.4 5.91 0.31 8.59e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs6088580 0.634 rs6059860 chr20:33063830 A/C cg24642439 chr20:33292090 TP53INP2 0.37 6.23 0.32 1.41e-9 Glomerular filtration rate (creatinine); CRC cis rs4332037 0.539 rs55993248 chr7:2071132 A/G cg23422044 chr7:1970798 MAD1L1 -0.57 -6.96 -0.36 1.86e-11 Bipolar disorder; CRC cis rs881375 0.967 rs10733648 chr9:123700779 A/G cg09419670 chr9:123605666 PSMD5;LOC253039 0.56 8.28 0.42 3.21e-15 Rheumatoid arthritis; CRC cis rs867529 0.695 rs62157805 chr2:89014728 T/C cg26627705 chr2:89060884 NA -0.57 -7.48 -0.38 6.63e-13 Height; CRC cis rs68170813 0.559 rs10953530 chr7:106827796 A/C cg02696742 chr7:106810147 HBP1 -0.6 -7.02 -0.36 1.28e-11 Coronary artery disease; CRC trans rs7647973 0.677 rs11130211 chr3:49645209 C/T cg21659725 chr3:3221576 CRBN -0.66 -7.14 -0.37 5.85e-12 Menarche (age at onset); CRC cis rs10924970 0.934 rs12402243 chr1:235431792 A/C cg26050004 chr1:235667680 B3GALNT2 0.39 5.8 0.3 1.56e-8 Asthma; CRC cis rs5769765 0.908 rs4074304 chr22:50309446 G/A cg04121214 chr22:50244548 NA 0.41 5.81 0.3 1.49e-8 Schizophrenia; CRC cis rs2243480 1.000 rs58669269 chr7:65951953 T/C cg25985355 chr7:65971099 NA -0.53 -6.02 -0.32 4.64e-9 Diabetic kidney disease; CRC cis rs1003719 0.667 rs8127148 chr21:38481292 G/A cg10648535 chr21:38446584 PIGP;TTC3 0.48 6.86 0.35 3.34e-11 Eye color traits; CRC cis rs1552244 0.882 rs13064570 chr3:9997545 G/C cg02579736 chr3:10068473 FANCD2;CIDECP 0.91 11.74 0.54 7.8e-27 Alzheimer's disease; CRC cis rs2070997 0.702 rs11793797 chr9:133755282 T/G cg01000188 chr9:133769184 QRFP 0.56 5.75 0.3 2e-8 Response to amphetamines; CRC cis rs919433 0.817 rs10931780 chr2:198175297 G/C cg10820045 chr2:198174542 NA -0.59 -12.03 -0.55 7.03e-28 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC cis rs1223397 0.938 rs17700321 chr6:13280666 G/T cg20827128 chr6:13274284 PHACTR1 0.54 6.54 0.34 2.32e-10 Blood pressure; CRC cis rs1707322 1.000 rs6671754 chr1:46433990 A/G cg03146154 chr1:46216737 IPP 0.51 7.06 0.36 1.01e-11 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs9322193 0.962 rs9397357 chr6:150133601 G/A cg04369109 chr6:150039330 LATS1 -0.43 -5.95 -0.31 7.05e-9 Lung cancer; CRC cis rs9311676 0.632 rs11130642 chr3:58420042 C/T cg06643156 chr3:58380774 PXK 0.42 6.43 0.33 4.39e-10 Systemic lupus erythematosus; CRC cis rs853679 0.517 rs12332979 chr6:28141548 T/G cg03623178 chr6:28175578 NA 0.97 12.38 0.56 3.55e-29 Depression; CRC trans rs853679 0.760 rs9357067 chr6:28210293 C/G cg06606381 chr12:133084897 FBRSL1 -0.65 -6.7 -0.35 8.99e-11 Depression; CRC cis rs3820068 0.655 rs11587521 chr1:15839206 T/C cg27534772 chr1:16042836 PLEKHM2 0.42 7.07 0.36 9.23e-12 Systolic blood pressure; CRC cis rs9911578 0.704 rs72628393 chr17:56585314 A/T cg12560992 chr17:57184187 TRIM37 -0.9 -16.52 -0.67 4.76e-45 Intelligence (multi-trait analysis); CRC cis rs4862750 0.914 rs6553026 chr4:187875648 C/T cg11301795 chr4:187892539 NA -0.84 -18.54 -0.71 4.83e-53 Lobe attachment (rater-scored or self-reported); CRC cis rs7937682 0.575 rs34888817 chr11:111756455 C/T cg19812747 chr11:111475976 SIK2 0.42 6.23 0.32 1.44e-9 Primary sclerosing cholangitis; CRC cis rs4713118 0.516 rs4713142 chr6:28106347 T/G cg18032046 chr6:28092343 ZSCAN16 -0.52 -6.08 -0.32 3.3e-9 Parkinson's disease; CRC cis rs7945705 0.776 rs2316865 chr11:8815470 A/G cg21881798 chr11:8931708 C11orf17;ST5 0.48 7.08 0.36 8.73e-12 Hemoglobin concentration; CRC cis rs739401 0.869 rs395188 chr11:3072631 A/G cg08508325 chr11:3079039 CARS 0.39 6.86 0.35 3.32e-11 Longevity; CRC cis rs8031584 0.736 rs11635775 chr15:31160640 A/G cg08109568 chr15:31115862 NA -0.7 -10.5 -0.5 1.96e-22 Huntington's disease progression; CRC cis rs875971 0.505 rs1167385 chr7:65513308 G/A cg18876405 chr7:65276391 NA -0.64 -11.51 -0.54 5.4e-26 Aortic root size; CRC trans rs295140 0.647 rs295132 chr2:201233502 A/G cg05062854 chr22:32435553 NA 0.39 6.03 0.32 4.48e-9 QT interval; CRC cis rs7937682 0.961 rs4935790 chr11:111633014 T/C cg19812747 chr11:111475976 SIK2 0.48 7.57 0.39 3.87e-13 Primary sclerosing cholangitis; CRC cis rs11212617 0.870 rs227063 chr11:108207304 T/G cg12106634 chr11:108092400 ATM;NPAT 0.43 6.45 0.33 4.03e-10 Response to metformin in type 2 diabetes (glycemic); CRC cis rs9583531 1.000 rs9583531 chr13:111385161 T/G cg24331049 chr13:111365604 ING1 -0.48 -5.71 -0.3 2.59e-8 Coronary artery disease; CRC cis rs2204008 0.837 rs1842599 chr12:37986081 G/A cg13010199 chr12:38710504 ALG10B -0.5 -7.4 -0.38 1.18e-12 Bladder cancer; CRC cis rs875971 0.964 rs778721 chr7:65845397 C/G cg00343986 chr7:65444356 GUSB 0.43 6.3 0.33 9.66e-10 Aortic root size; CRC cis rs877282 0.898 rs12358513 chr10:757571 A/G cg17470449 chr10:769945 NA 0.64 8.39 0.42 1.42e-15 Uric acid levels; CRC cis rs2576037 0.583 rs646128 chr18:44397691 A/C cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.55 -8.36 -0.42 1.75e-15 Personality dimensions; CRC cis rs873946 0.586 rs3793685 chr10:134569316 G/A cg27286337 chr10:134555280 INPP5A 0.82 9.97 0.48 1.25e-20 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CRC cis rs7666738 0.861 rs28821920 chr4:98962743 T/C cg05340658 chr4:99064831 C4orf37 0.61 9.45 0.46 6.55e-19 Colonoscopy-negative controls vs population controls; CRC trans rs35110281 0.659 rs11702544 chr21:45091861 C/T cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.41 6.76 0.35 6.41e-11 Mean corpuscular volume; CRC cis rs798554 0.797 rs798494 chr7:2798294 C/A cg14895029 chr7:2775587 GNA12 -0.46 -6.8 -0.35 4.87e-11 Height; CRC cis rs10857712 0.754 rs1052582 chr10:135233840 C/G cg19904058 chr10:135279010 LOC619207 -0.35 -6.78 -0.35 5.56e-11 Systemic lupus erythematosus; CRC cis rs2979489 0.945 rs13250272 chr8:30294942 A/G cg26383811 chr8:30366931 RBPMS 0.7 9.62 0.47 1.89e-19 Mean corpuscular hemoglobin;Plateletcrit;Neutrophil count;Granulocyte count;Sum basophil neutrophil counts;Mean corpuscular volume;Myeloid white cell count;Sum neutrophil eosinophil counts; CRC cis rs8103278 0.507 rs7260651 chr19:46260245 G/A cg20908204 chr19:46285434 DMPK 0.33 7.44 0.38 9.07e-13 Coronary artery disease; CRC trans rs17685 0.753 rs10476 chr7:75696420 C/T cg19862616 chr7:65841803 NCRNA00174 -0.94 -17.41 -0.69 1.42e-48 Coffee consumption;Coffee consumption (cups per day); CRC cis rs875971 0.545 rs10950029 chr7:65634321 A/C cg03233332 chr7:66118400 NA -0.45 -6.45 -0.33 4.03e-10 Aortic root size; CRC cis rs17253792 0.822 rs10147380 chr14:56054354 T/C cg01858014 chr14:56050164 KTN1 -0.88 -7.83 -0.4 6.57e-14 Putamen volume; CRC cis rs514406 0.755 rs11206015 chr1:53242187 T/C cg27535305 chr1:53392650 SCP2 0.38 7.28 0.37 2.55e-12 Monocyte count; CRC trans rs9460578 0.561 rs6913323 chr6:20891190 A/T cg14519598 chr9:36906608 PAX5 -0.47 -6.2 -0.32 1.74e-9 Breast cancer; CRC cis rs7914558 1.000 rs10883824 chr10:104812897 A/G cg15744005 chr10:104629667 AS3MT -0.33 -6.98 -0.36 1.64e-11 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC cis rs62064224 0.614 rs4794923 chr17:30763009 G/A cg12855166 chr17:30846586 MYO1D -0.37 -6.01 -0.31 4.94e-9 Schizophrenia; CRC cis rs11098499 0.863 rs1552095 chr4:120460306 A/G cg24375607 chr4:120327624 NA 0.48 7.03 0.36 1.2e-11 Corneal astigmatism; CRC cis rs10905065 0.804 rs2380203 chr10:5810897 A/G cg11519256 chr10:5708881 ASB13 0.5 7.36 0.38 1.53e-12 Menopause (age at onset); CRC cis rs7044106 0.762 rs1324473 chr9:123404610 C/T cg09586646 chr9:123605570 PSMD5;LOC253039 -0.63 -9.39 -0.46 9.92e-19 Hip circumference adjusted for BMI; CRC cis rs2276314 1.000 rs1789513 chr18:33545630 A/G cg19628046 chr18:33552617 C18orf21 -0.53 -7.23 -0.37 3.49e-12 Endometriosis;Drug-induced torsades de pointes; CRC cis rs10979 0.631 rs12530338 chr6:143872563 C/T cg25407410 chr6:143891975 LOC285740 -0.51 -7.14 -0.37 6.03e-12 Hypospadias; CRC cis rs2032447 0.831 rs9467664 chr6:26021813 A/T cg12310025 chr6:25882481 NA -0.53 -7.35 -0.38 1.59e-12 Intelligence (multi-trait analysis); CRC cis rs7618915 0.501 rs11714030 chr3:52765882 C/T cg18404041 chr3:52824283 ITIH1 -0.39 -8.23 -0.41 4.37e-15 Bipolar disorder; CRC cis rs2153535 0.601 rs2327091 chr6:8540369 G/A cg21535247 chr6:8435926 SLC35B3 0.5 7.72 0.39 1.45e-13 Motion sickness; CRC cis rs12188164 0.930 rs72717436 chr5:448291 C/A cg26850624 chr5:429559 AHRR -0.81 -13.6 -0.6 9.63e-34 Cystic fibrosis severity; CRC cis rs3823572 0.504 rs2346268 chr7:133642742 G/A cg03336402 chr7:133662267 EXOC4 -0.67 -10.39 -0.5 4.59e-22 Intelligence (multi-trait analysis); CRC cis rs4731207 0.596 rs2402763 chr7:124709732 A/G cg23710748 chr7:124431027 NA -0.39 -6.08 -0.32 3.3e-9 Cutaneous malignant melanoma; CRC cis rs679087 1.000 rs436124 chr12:29916839 C/T cg14258853 chr12:29935411 TMTC1 0.46 8.08 0.41 1.26e-14 Schizophrenia; CRC cis rs8044868 0.586 rs3844425 chr16:72194325 T/C cg23815491 chr16:72088622 HP 0.44 6.45 0.34 3.92e-10 Body mass index (change over time) in cancer or chronic obstructive pulmonary disease;Body mass index (change over time) in cancer; CRC cis rs11719291 0.833 rs13074318 chr3:48816725 C/T cg01304814 chr3:48885189 PRKAR2A 0.75 5.91 0.31 8.55e-9 Cognitive function; CRC cis rs9837602 1.000 rs9832186 chr3:99728503 G/C cg07805332 chr3:99536008 MIR548G;C3orf26 -0.49 -6.37 -0.33 6.39e-10 Breast cancer; CRC cis rs6840360 0.642 rs7677131 chr4:152353015 T/C cg09659197 chr4:152720779 NA 0.34 6.66 0.34 1.14e-10 Intelligence (multi-trait analysis); CRC cis rs9341808 0.754 rs9341810 chr6:80974838 G/A cg08355045 chr6:80787529 NA 0.39 6.4 0.33 5.2e-10 Sitting height ratio; CRC cis rs2739330 0.828 rs2877178 chr22:24251517 C/T cg11060661 chr22:24314208 DDT;DDTL 0.5 8.44 0.42 1.02e-15 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs3996993 0.724 rs2749014 chr6:52627322 G/A cg20803780 chr6:52668592 GSTA1 -0.32 -5.64 -0.3 3.71e-8 Hemoglobin concentration; CRC cis rs6921919 0.638 rs1416920 chr6:28302784 A/G cg21251018 chr6:28226885 NKAPL 0.49 7.8 0.4 8.17e-14 Autism spectrum disorder or schizophrenia; CRC cis rs4589502 0.841 rs55855162 chr15:67140523 C/A cg12317470 chr15:67143691 NA 0.73 6.4 0.33 5.37e-10 Lung cancer (smoking interaction); CRC cis rs853679 0.517 rs9380060 chr6:28132603 G/A cg02631126 chr6:28058918 ZSCAN12L1 0.29 5.91 0.31 8.38e-9 Depression; CRC cis rs6968419 0.747 rs9969224 chr7:115861660 T/C cg02561103 chr7:115862891 TES -0.42 -6.31 -0.33 9.04e-10 Intraocular pressure; CRC cis rs4332037 0.539 rs1533827 chr7:2074290 A/G cg25834613 chr7:1915315 MAD1L1 0.42 6.1 0.32 3.04e-9 Bipolar disorder; CRC cis rs2019137 0.560 rs4849179 chr2:113985170 C/T cg07772999 chr2:113993052 PAX8;LOC440839;LOC654433 0.54 8.22 0.41 4.87e-15 Lymphocyte counts; CRC cis rs752010 0.655 rs10890145 chr1:42086290 A/G cg06885757 chr1:42089581 HIVEP3 0.51 9.11 0.45 8.4e-18 Lupus nephritis in systemic lupus erythematosus; CRC cis rs1448094 0.556 rs11610627 chr12:86167752 C/T cg25456477 chr12:86230367 RASSF9 0.4 6.71 0.35 8.75e-11 Major depressive disorder; CRC cis rs524281 0.861 rs7946917 chr11:65956577 A/G cg14036092 chr11:66035641 RAB1B -0.47 -5.71 -0.3 2.54e-8 Electroencephalogram traits; CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg02276845 chr11:3876248 STIM1 -0.56 -6.61 -0.34 1.59e-10 Diisocyanate-induced asthma; CRC cis rs7209700 0.778 rs3851807 chr17:45351519 C/G cg17185639 chr17:45330862 ITGB3 0.35 5.96 0.31 6.4e-9 IgG glycosylation; CRC cis rs9818758 0.556 rs73077200 chr3:49826987 C/T cg01304814 chr3:48885189 PRKAR2A 0.92 6.64 0.34 1.29e-10 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; CRC cis rs3736485 0.966 rs4775944 chr15:51775610 T/C cg08986416 chr15:51914746 DMXL2 -0.45 -6.43 -0.33 4.41e-10 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs9733 0.596 rs72702556 chr1:150680115 C/T cg17724175 chr1:150552817 MCL1 0.57 9.12 0.45 7.76e-18 Tonsillectomy; CRC cis rs1577917 0.958 rs2100109 chr6:86544926 T/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.51 -6.67 -0.35 1.07e-10 Response to antipsychotic treatment; CRC cis rs12451471 0.559 rs34746710 chr17:78079224 G/A cg12100956 chr17:78086420 GAA -0.38 -6.08 -0.32 3.39e-9 Plateletcrit;Mean corpuscular hemoglobin concentration; CRC cis rs10242455 0.571 rs80045298 chr7:99307453 T/A cg18809830 chr7:99032528 PTCD1 -1.05 -7.59 -0.39 3.23e-13 Blood metabolite levels; CRC cis rs7192750 0.583 rs2550043 chr16:72067491 T/C cg14768367 chr16:72042858 DHODH 0.83 6.41 0.33 5.11e-10 LDL cholesterol levels;Total cholesterol levels; CRC cis rs478304 0.903 rs1151502 chr11:65503485 G/C cg08755490 chr11:65554678 OVOL1 0.43 6.39 0.33 5.53e-10 Acne (severe); CRC trans rs3733585 0.699 rs57574512 chr4:9960182 T/C cg26043149 chr18:55253948 FECH -0.5 -7.62 -0.39 2.81e-13 Cleft plate (environmental tobacco smoke interaction); CRC cis rs10504229 0.683 rs59679713 chr8:58134370 G/C cg05313129 chr8:58192883 C8orf71 -0.43 -6.07 -0.32 3.55e-9 Developmental language disorder (linguistic errors); CRC cis rs7762018 0.607 rs78941587 chr6:170061157 G/C cg19338460 chr6:170058176 WDR27 -1.21 -11.42 -0.53 1.14e-25 Thiazide-induced adverse metabolic effects in hypertensive patients; CRC trans rs55637147 0.671 rs4939140 chr11:57130473 G/T cg22097425 chr11:125774311 DDX25;PUS3 -0.32 -5.96 -0.31 6.45e-9 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; CRC cis rs1048238 0.506 rs56352596 chr1:16297592 G/A cg21385522 chr1:16154831 NA 0.6 8.81 0.44 7.53e-17 Systolic blood pressure; CRC cis rs8180040 0.966 rs11925823 chr3:47443065 C/G cg02527881 chr3:46936655 PTH1R -0.39 -7.46 -0.38 7.55e-13 Colorectal cancer; CRC cis rs477692 1.000 rs577227 chr10:131404528 C/T cg05714579 chr10:131428358 MGMT 0.51 7.54 0.38 4.75e-13 Response to temozolomide; CRC trans rs853679 0.607 rs13190888 chr6:28285985 G/A cg06606381 chr12:133084897 FBRSL1 -1.44 -10.94 -0.52 5.61e-24 Depression; CRC cis rs6546324 0.580 rs4410279 chr2:67850620 A/C cg15745817 chr2:67799979 NA -0.55 -9.5 -0.46 4.36e-19 Endometriosis; CRC cis rs17376456 0.877 rs10061080 chr5:93420559 A/G cg21475434 chr5:93447410 FAM172A 0.68 7.38 0.38 1.34e-12 Diabetic retinopathy; CRC cis rs10924970 0.781 rs10802590 chr1:235444051 A/G cg26050004 chr1:235667680 B3GALNT2 0.4 6.01 0.31 4.84e-9 Asthma; CRC trans rs10506458 0.915 rs56321182 chr12:63392023 C/T cg22491629 chr6:157744540 C6orf35 -0.76 -8.95 -0.44 2.67e-17 Hemostatic factors and hematological phenotypes; CRC cis rs2455601 0.608 rs16906256 chr11:8887097 A/G cg21881798 chr11:8931708 C11orf17;ST5 -0.51 -6.73 -0.35 7.37e-11 Schizophrenia; CRC cis rs477692 0.647 rs11016853 chr10:131443990 A/G cg05714579 chr10:131428358 MGMT -0.71 -11.01 -0.52 3.16e-24 Response to temozolomide; CRC cis rs8180040 0.701 rs7617689 chr3:46996442 C/T cg27129171 chr3:47204927 SETD2 -0.66 -10.47 -0.5 2.49e-22 Colorectal cancer; CRC cis rs896854 0.967 rs13257021 chr8:95965695 A/G cg16049864 chr8:95962084 TP53INP1 -0.68 -12.38 -0.56 3.72e-29 Type 2 diabetes; CRC cis rs6901250 0.568 rs4946198 chr6:117176599 C/T cg12892004 chr6:117198278 RFX6 -0.42 -6.18 -0.32 1.88e-9 C-reactive protein levels; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg23260255 chr3:187871479 LPP 0.49 6.43 0.33 4.55e-10 Thyroid stimulating hormone; CRC cis rs1005277 0.579 rs2472183 chr10:38392495 T/G cg25427524 chr10:38739819 LOC399744 -0.77 -13.64 -0.6 6.85e-34 Extrinsic epigenetic age acceleration; CRC cis rs6963495 0.745 rs68153235 chr7:105184832 A/C cg02135003 chr7:105160482 PUS7 -0.67 -10.05 -0.48 6.81e-21 Bipolar disorder (body mass index interaction); CRC trans rs57221529 0.766 rs72706610 chr5:561111 G/A cg25482853 chr8:67687455 SGK3 1.25 15.65 0.65 1.15e-41 Lung disease severity in cystic fibrosis; CRC cis rs6952808 0.692 rs12666575 chr7:2004421 C/T cg02951883 chr7:2050386 MAD1L1 -0.75 -11.86 -0.55 2.85e-27 Bipolar disorder and schizophrenia; CRC cis rs2898681 0.519 rs6848200 chr4:53730181 A/G cg26260408 chr4:53727979 RASL11B 0.41 5.86 0.31 1.12e-8 Optic nerve measurement (cup area); CRC cis rs9926296 0.715 rs467035 chr16:89740285 C/G cg01097406 chr16:89675127 NA -0.49 -8.88 -0.44 4.45e-17 Vitiligo; CRC cis rs7312933 0.703 rs10880264 chr12:42586535 A/G cg11827402 chr12:42719852 PPHLN1;ZCRB1 0.64 8.83 0.44 6.17e-17 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CRC cis rs514406 0.861 rs10888755 chr1:53240829 A/G cg08859206 chr1:53392774 SCP2 0.43 6.76 0.35 6.17e-11 Monocyte count; CRC cis rs10991814 0.920 rs16907297 chr9:94008934 T/C cg14446406 chr9:93919335 NA 0.5 5.61 0.3 4.33e-8 Neutrophil percentage of granulocytes; CRC cis rs6598955 0.543 rs6698557 chr1:26561220 G/C cg04990556 chr1:26633338 UBXN11 0.84 10.31 0.49 8.57e-22 Obesity-related traits; CRC cis rs736408 0.562 rs13071584 chr3:52804487 T/C cg05573699 chr3:52720067 GNL3;PBRM1 -0.47 -6.84 -0.35 3.87e-11 Bipolar disorder; CRC cis rs9311474 0.569 rs7614981 chr3:52566914 G/T cg11645453 chr3:52864694 ITIH4 0.35 6.58 0.34 1.89e-10 Electroencephalogram traits; CRC cis rs8067545 0.611 rs12942568 chr17:20117893 G/T cg13482628 chr17:19912719 NA -0.46 -7.29 -0.37 2.37e-12 Schizophrenia; CRC cis rs6503525 0.628 rs62068171 chr17:38103242 G/A cg17467752 chr17:38218738 THRA 0.41 6.14 0.32 2.42e-9 Asthma; CRC trans rs951252 0.504 rs11734405 chr4:146081096 C/T cg00556514 chr3:38066524 PLCD1 0.5 6.45 0.34 4.09e-10 Hip circumference; CRC cis rs8180040 0.522 rs749512 chr3:47035900 C/T cg27129171 chr3:47204927 SETD2 -0.64 -9.68 -0.47 1.13e-19 Colorectal cancer; CRC cis rs7662987 0.517 rs1154406 chr4:100008494 T/C cg12011299 chr4:100065546 ADH4 0.49 9.16 0.45 5.55e-18 Smoking initiation; CRC cis rs9649213 0.593 rs13246942 chr7:97915021 C/T cg24562669 chr7:97807699 LMTK2 0.46 7.82 0.4 7.01e-14 Prostate cancer (SNP x SNP interaction); CRC cis rs96067 0.805 rs12033824 chr1:36600307 C/T cg25304816 chr1:36627734 MAP7D1 0.42 6.03 0.32 4.36e-9 Corneal structure; CRC trans rs916888 0.610 rs199438 chr17:44791643 G/A cg10053473 chr17:62856997 LRRC37A3 -0.65 -8.83 -0.44 6.57e-17 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs10479542 0.583 rs4131080 chr5:179044292 G/A cg05457628 chr5:178986728 RUFY1 0.38 5.88 0.31 1e-8 Lung cancer; CRC cis rs11758351 0.660 rs11757754 chr6:26219744 A/C cg08260959 chr6:26240920 HIST1H4F -0.35 -5.6 -0.3 4.44e-8 Gout;Renal underexcretion gout; CRC cis rs7772486 0.754 rs4896841 chr6:146041522 T/C cg05347473 chr6:146136440 FBXO30 -0.38 -5.67 -0.3 3.1e-8 Lobe attachment (rater-scored or self-reported); CRC cis rs9649213 0.574 rs3801251 chr7:98027618 T/C cg00277769 chr7:97922759 BAIAP2L1 -0.57 -9.69 -0.47 1.06e-19 Prostate cancer (SNP x SNP interaction); CRC cis rs11792861 0.926 rs7870597 chr9:111871864 T/C cg05043794 chr9:111880884 C9orf5 -0.36 -6.55 -0.34 2.2e-10 Menarche (age at onset); CRC cis rs17092148 0.887 rs2144956 chr20:33145868 G/A cg08999081 chr20:33150536 PIGU 0.5 6.44 0.33 4.27e-10 Neuroticism; CRC cis rs2721195 1.000 rs6599530 chr8:145677418 C/G cg11211951 chr8:145729740 GPT -0.37 -6.45 -0.34 3.98e-10 Age at first birth; CRC cis rs10911232 0.507 rs4422969 chr1:183020762 G/A ch.1.3577855R chr1:183094577 LAMC1 0.83 14.62 0.63 1.22e-37 Hypertriglyceridemia; CRC cis rs9457247 0.534 rs7750593 chr6:167387359 C/G cg23791538 chr6:167370224 RNASET2 0.47 7.49 0.38 6.2800000000000005e-13 Crohn's disease; CRC cis rs4332037 0.754 rs62436669 chr7:1926636 G/A cg02421172 chr7:1938701 MAD1L1 0.45 6.09 0.32 3.07e-9 Bipolar disorder; CRC cis rs2396545 0.638 rs1062099 chr11:567627 G/C cg09218773 chr11:619014 MUPCDH -0.41 -5.63 -0.3 3.78e-8 Systemic lupus erythematosus and Systemic sclerosis; CRC cis rs262150 0.501 rs2730206 chr7:158815173 G/C cg19418458 chr7:158789849 NA -0.49 -8.39 -0.42 1.48e-15 Facial morphology (factor 20); CRC cis rs9916302 0.904 rs9894500 chr17:37515735 G/C cg15445000 chr17:37608096 MED1 -0.42 -9.25 -0.45 2.86e-18 Glomerular filtration rate (creatinine); CRC cis rs67340775 0.541 rs200966 chr6:27862152 T/C cg26587870 chr6:27730563 NA -0.55 -6.52 -0.34 2.67e-10 Lung cancer in ever smokers; CRC trans rs75828804 1.000 rs77561412 chr16:77607089 A/G cg19423196 chr10:82049429 MAT1A 0.58 6.21 0.32 1.56e-9 Intraocular pressure; CRC cis rs2404602 0.716 rs8025134 chr15:76781729 C/T cg22467129 chr15:76604101 ETFA -0.46 -7.75 -0.39 1.12e-13 Blood metabolite levels; CRC cis rs45509595 0.841 rs370155 chr6:27782031 T/G cg23259851 chr6:27775964 HIST1H2AI;HIST1H2BL 0.67 5.69 0.3 2.85e-8 Breast cancer; CRC cis rs514406 0.668 rs1672911 chr1:53340320 T/C cg08859206 chr1:53392774 SCP2 -0.6 -9.47 -0.46 5.52e-19 Monocyte count; CRC cis rs6089584 0.850 rs881993 chr20:60623862 A/G cg06108461 chr20:60628389 TAF4 -0.92 -15.88 -0.66 1.52e-42 Body mass index; CRC cis rs12325245 0.536 rs34129245 chr16:58588191 A/G cg26666090 chr16:58549219 SETD6 0.92 6.25 0.33 1.26e-9 Schizophrenia; CRC cis rs8077889 0.672 rs3785810 chr17:41850689 C/G cg26893861 chr17:41843967 DUSP3 1.08 22.0 0.77 1.28e-66 Triglycerides; CRC trans rs2727020 0.615 rs4980435 chr11:49591576 G/A cg15704280 chr7:45808275 SEPT13 -0.95 -18.37 -0.71 2.21e-52 Coronary artery disease; CRC cis rs7666738 0.830 rs28416660 chr4:98899525 C/G cg05340658 chr4:99064831 C4orf37 0.57 8.57 0.43 4.13e-16 Colonoscopy-negative controls vs population controls; CRC cis rs4132509 1.000 rs57824597 chr1:243930399 C/T cg21452805 chr1:244014465 NA 0.5 6.76 0.35 6.47e-11 RR interval (heart rate); CRC cis rs274567 0.501 rs2631368 chr5:131705297 T/G cg20512303 chr5:131592959 PDLIM4 -0.38 -6.6 -0.34 1.6e-10 Blood metabolite levels; CRC trans rs8073060 0.963 rs4795082 chr17:33873501 C/T cg19694781 chr19:47549865 TMEM160 0.52 7.68 0.39 1.89e-13 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; CRC cis rs1799949 0.930 rs3765640 chr17:41276247 A/G cg01879757 chr17:41196368 BRCA1 -0.43 -6.61 -0.34 1.54e-10 Menopause (age at onset); CRC cis rs2050392 0.965 rs1543725 chr10:30698873 A/G cg18806716 chr10:30721971 MAP3K8 -0.46 -7.13 -0.37 6.51e-12 Inflammatory bowel disease; CRC cis rs6912958 0.712 rs2787927 chr6:88412786 A/G cg12350822 chr6:88032061 C6orf162;GJB7 -0.32 -5.81 -0.31 1.45e-8 Monocyte percentage of white cells; CRC cis rs11166629 1.000 rs935119 chr8:135638353 C/T cg27224718 chr8:135614730 ZFAT -0.47 -7.46 -0.38 7.76e-13 Smoking quantity; CRC cis rs4713118 0.868 rs10484401 chr6:27746590 A/T cg25164649 chr6:28176230 NA -0.66 -7.43 -0.38 9.46e-13 Parkinson's disease; CRC cis rs7605827 0.930 rs2160691 chr2:15598197 G/A cg19274914 chr2:15703543 NA 0.4 6.06 0.32 3.81e-9 Educational attainment (years of education); CRC cis rs1005277 0.540 rs116205409 chr10:38478970 G/A cg17219203 chr10:38645113 HSD17B7P2 -0.4 -5.61 -0.3 4.37e-8 Extrinsic epigenetic age acceleration; CRC cis rs28374715 0.635 rs8023530 chr15:41647775 T/C cg18705301 chr15:41695430 NDUFAF1 -0.87 -14.47 -0.62 4.47e-37 Ulcerative colitis; CRC cis rs2842992 0.789 rs4235925 chr6:160202860 C/T cg16489826 chr6:160211363 TCP1;MRPL18 0.48 6.1 0.32 3.01e-9 Age-related macular degeneration (geographic atrophy); CRC cis rs11758351 0.660 rs113208674 chr6:26210465 C/G cg22723502 chr6:26240528 HIST1H4F -0.37 -6.09 -0.32 3.11e-9 Gout;Renal underexcretion gout; CRC trans rs950037 0.681 rs7518750 chr1:89148503 A/C cg26267483 chr5:156143683 SGCD 0.4 5.96 0.31 6.43e-9 Coronary artery disease; CRC cis rs2839186 0.619 rs2187118 chr21:47611310 C/T cg11766577 chr21:47581405 C21orf56 -0.38 -5.93 -0.31 7.62e-9 Testicular germ cell tumor; CRC cis rs10927875 0.541 rs1739843 chr1:16343254 T/C cg24140574 chr1:16342155 HSPB7 0.47 6.74 0.35 7.16e-11 Dilated cardiomyopathy; CRC cis rs2806561 0.578 rs6702719 chr1:23302576 T/C cg12483005 chr1:23474871 LUZP1 0.45 6.41 0.33 5.04e-10 Height; CRC cis rs11608355 0.960 rs3742021 chr12:109883117 T/C cg19025524 chr12:109796872 NA -0.46 -6.5 -0.34 2.98e-10 Neuroticism; CRC cis rs7615952 0.576 rs4646759 chr3:125822946 G/C cg06494592 chr3:125709126 NA -0.57 -6.79 -0.35 5.14e-11 Blood pressure (smoking interaction); CRC cis rs10504229 1.000 rs56740825 chr8:58175617 A/G cg24829409 chr8:58192753 C8orf71 -0.68 -11.34 -0.53 2.27e-25 Developmental language disorder (linguistic errors); CRC cis rs4862750 1.000 rs4862751 chr4:187904050 G/A cg03647317 chr4:187891568 NA -0.54 -9.67 -0.47 1.26e-19 Lobe attachment (rater-scored or self-reported); CRC cis rs4332037 0.539 rs56016347 chr7:2060126 C/T cg25834613 chr7:1915315 MAD1L1 -0.42 -5.93 -0.31 7.82e-9 Bipolar disorder; CRC cis rs2354432 0.607 rs6689243 chr1:146710559 A/T cg25205988 chr1:146714368 CHD1L -1.17 -10.05 -0.48 6.71e-21 Mitochondrial DNA levels; CRC cis rs300703 0.935 rs10167992 chr2:263270 C/T cg21211680 chr2:198530 NA -0.79 -7.7 -0.39 1.59e-13 Blood protein levels; CRC cis rs2066819 1.000 rs11575232 chr12:56744422 G/A cg26714650 chr12:56694279 CS -1.44 -11.18 -0.52 8.02e-25 Psoriasis vulgaris; CRC trans rs1814175 0.645 rs1818895 chr11:50031523 G/T cg15704280 chr7:45808275 SEPT13 -0.93 -16.86 -0.68 2e-46 Height; CRC cis rs1179624 0.679 rs4731232 chr7:75264765 G/A cg05145297 chr7:75264568 HIP1 0.6 8.2 0.41 5.44e-15 Age-related nuclear cataracts; CRC cis rs6088590 1.000 rs2180276 chr20:33360785 T/A cg08999081 chr20:33150536 PIGU 0.51 8.68 0.43 1.9e-16 Coronary artery disease; CRC cis rs4862750 0.914 rs1863405 chr4:187874528 G/T cg07414643 chr4:187882934 NA -0.36 -6.32 -0.33 8.52e-10 Lobe attachment (rater-scored or self-reported); CRC cis rs1018836 0.886 rs4734246 chr8:91569028 A/C cg16814680 chr8:91681699 NA -0.74 -11.74 -0.54 8.38e-27 Ejection fraction in Tripanosoma cruzi seropositivity; CRC cis rs9287719 0.967 rs4669593 chr2:10701908 C/T cg00105475 chr2:10696890 NA 0.46 7.47 0.38 7.36e-13 Prostate cancer; CRC cis rs763014 0.966 rs4984903 chr16:680695 A/G cg00802000 chr16:706648 WDR90 -0.42 -6.03 -0.32 4.47e-9 Height; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg04172079 chr20:35974269 SRC 0.42 6.04 0.32 4.1e-9 Intelligence (multi-trait analysis); CRC cis rs1129187 0.755 rs9471982 chr6:42935998 G/A cg02359409 chr6:42947317 PEX6 -0.69 -11.52 -0.54 5e-26 Alzheimer's disease in APOE e4+ carriers; CRC trans rs800082 0.934 rs1007566 chr3:144311752 G/A cg24215973 chr2:240111563 HDAC4 -0.52 -7.28 -0.37 2.53e-12 Smoking behavior; CRC cis rs11190604 1.000 rs7085439 chr10:102210100 C/T cg07080220 chr10:102295463 HIF1AN 0.47 5.79 0.3 1.63e-8 Palmitoleic acid (16:1n-7) levels; CRC cis rs1008375 1.000 rs3846357 chr4:17635887 A/T cg16339924 chr4:17578868 LAP3 0.57 7.72 0.39 1.4e-13 Parasitemia in Tripanosoma cruzi seropositivity; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg12843489 chr17:35061545 NA 0.29 6.77 0.35 6.02e-11 Liver disease severity in Alagille syndrome; CRC cis rs611744 0.538 rs13257548 chr8:109273185 G/A cg18478394 chr8:109455254 TTC35 0.42 6.24 0.33 1.36e-9 Dupuytren's disease; CRC cis rs7843479 0.511 rs4379446 chr8:21777595 C/G cg17168535 chr8:21777572 XPO7 0.68 11.63 0.54 1.97e-26 Mean corpuscular volume; CRC trans rs877282 0.898 rs11253350 chr10:765968 G/A cg22713356 chr15:30763199 NA 1.3 15.02 0.64 3.32e-39 Uric acid levels; CRC trans rs561341 0.941 rs2428341 chr17:30317295 C/T cg20587970 chr11:113659929 NA -0.98 -14.32 -0.62 1.7e-36 Hip circumference adjusted for BMI; CRC cis rs4363385 0.510 rs6693927 chr1:153044009 G/A cg25856811 chr1:152973957 SPRR3 -0.21 -5.69 -0.3 2.74e-8 Inflammatory skin disease; CRC cis rs7224737 1.000 rs2285657 chr17:40272594 C/A cg20291162 chr17:40259547 DHX58 -0.55 -7.97 -0.4 2.57e-14 Fibrinogen levels; CRC cis rs2882667 0.728 rs10068786 chr5:138276944 C/T cg09476006 chr5:138032270 NA 0.56 9.15 0.45 6.17e-18 Age-related hearing impairment (SNP x SNP interaction); CRC cis rs11997175 0.646 rs6984073 chr8:33700070 G/A ch.8.33884649F chr8:33765107 NA 0.46 6.68 0.35 1.01e-10 Body mass index; CRC cis rs4728302 0.869 rs6955279 chr7:133612113 C/T cg03336402 chr7:133662267 EXOC4 -0.47 -6.86 -0.35 3.49e-11 Intelligence;Intelligence (multi-trait analysis); CRC cis rs3772130 0.962 rs11707518 chr3:121496568 G/A cg20356878 chr3:121714668 ILDR1 0.53 8.2 0.41 5.58e-15 Cognitive performance; CRC cis rs7666738 0.830 rs10440379 chr4:98902822 G/T cg17366294 chr4:99064904 C4orf37 0.41 6.76 0.35 6.13e-11 Colonoscopy-negative controls vs population controls; CRC trans rs8141529 0.507 rs5762936 chr22:29381377 A/G cg00867472 chr1:156714808 HDGF -0.45 -6.39 -0.33 5.75e-10 Lymphocyte counts; CRC cis rs4964805 0.672 rs4964823 chr12:104181420 A/T cg02344784 chr12:104178138 NT5DC3 0.53 7.68 0.39 1.88e-13 Attention deficit hyperactivity disorder; CRC cis rs3126085 0.825 rs4845428 chr1:152225261 T/C cg09127314 chr1:152161683 NA 0.46 5.92 0.31 8.22e-9 Atopic dermatitis; CRC cis rs7264396 0.616 rs6060744 chr20:34581555 T/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.49 -7.2 -0.37 4.11e-12 Total cholesterol levels; CRC cis rs11105298 0.891 rs8181784 chr12:89828591 A/G cg08166232 chr12:89918718 WDR51B;GALNT4 -0.47 -6.14 -0.32 2.33e-9 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; CRC cis rs9911578 1.000 rs3744108 chr17:56585872 G/C cg12560992 chr17:57184187 TRIM37 -0.9 -16.85 -0.68 2.39e-46 Intelligence (multi-trait analysis); CRC cis rs6988636 0.901 rs62521825 chr8:124185786 C/A cg27053337 chr8:124217698 FAM83A 0.45 6.84 0.35 3.77e-11 Urinary uromodulin levels; CRC cis rs9322193 0.923 rs2184369 chr6:150097817 G/A cg05861140 chr6:150128134 PCMT1 -0.43 -7.05 -0.36 1.03e-11 Lung cancer; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg19442480 chr19:14530103 DDX39 0.39 6.02 0.31 4.54e-9 Liver disease severity in Alagille syndrome; CRC cis rs5758659 0.653 rs133383 chr22:42473603 C/T cg25452165 chr22:42524984 CYP2D6 0.41 5.82 0.31 1.39e-8 Cognitive function; CRC cis rs61776719 0.875 rs10890238 chr1:38445654 A/T cg04673462 chr1:38461896 NA 0.38 6.53 0.34 2.56e-10 Coronary artery disease; CRC cis rs9926296 0.605 rs8046243 chr16:89852133 A/G cg27121462 chr16:89883253 FANCA 0.58 9.34 0.46 1.46e-18 Vitiligo; CRC cis rs7662987 0.517 rs3018048 chr4:100005538 C/T cg13256891 chr4:100009986 ADH5 0.63 8.39 0.42 1.41e-15 Smoking initiation; CRC cis rs1005277 0.579 rs9418322 chr10:38377296 G/T cg25517755 chr10:38738941 LOC399744 -0.44 -6.42 -0.33 4.69e-10 Extrinsic epigenetic age acceleration; CRC cis rs6570726 0.935 rs411641 chr6:145827532 G/A cg23711669 chr6:146136114 FBXO30 0.68 12.16 0.56 2.33e-28 Lobe attachment (rater-scored or self-reported); CRC cis rs34172651 0.917 rs17771137 chr16:24792242 G/A cg06028605 chr16:24865363 SLC5A11 0.43 7.82 0.4 7.39e-14 Intelligence (multi-trait analysis); CRC trans rs2303319 0.504 rs12470590 chr2:162493102 A/G cg04269497 chr6:167369491 RNASET2 -0.74 -6.06 -0.32 3.72e-9 Cognitive function; CRC cis rs798554 0.757 rs1182178 chr7:2873763 G/A cg17321639 chr7:2759063 NA -0.54 -7.2 -0.37 4.04e-12 Height; CRC cis rs1707322 0.686 rs1084086 chr1:46041100 A/C cg03146154 chr1:46216737 IPP -0.67 -9.7 -0.47 9.74e-20 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs35146811 0.695 rs858508 chr7:99821381 C/G cg13334819 chr7:99746414 C7orf59 0.56 7.27 0.37 2.61e-12 Coronary artery disease; CRC cis rs4988958 0.527 rs11465641 chr2:103000868 T/G cg03938978 chr2:103052716 IL18RAP 0.59 10.12 0.49 3.77e-21 Asthma (childhood onset); CRC trans rs57506017 0.517 rs16877363 chr7:12272026 A/G cg26461140 chr11:72811902 FCHSD2 0.58 6.53 0.34 2.54e-10 Neuroticism; CRC cis rs9611565 0.512 rs45500192 chr22:42177899 A/G cg17554472 chr22:41940697 POLR3H -0.57 -5.74 -0.3 2.21e-8 Vitiligo; CRC cis rs4073416 0.518 rs10150412 chr14:65916791 C/T cg03016385 chr14:66212404 NA -0.42 -5.74 -0.3 2.18e-8 N-glycan levels; CRC cis rs13191362 1.000 rs2156257 chr6:163100710 G/T cg23758597 chr6:163146217 PARK2 -0.67 -6.71 -0.35 8.57e-11 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs7527798 0.592 rs7539772 chr1:207833301 G/A cg21110645 chr1:207815933 NA -0.38 -5.79 -0.3 1.68e-8 Erythrocyte sedimentation rate; CRC cis rs57221529 0.825 rs7443550 chr5:578404 G/T cg09021430 chr5:549028 NA -0.72 -7.86 -0.4 5.63e-14 Lung disease severity in cystic fibrosis; CRC cis rs1670533 1.000 rs6852558 chr4:1059944 C/T cg27284194 chr4:1044797 NA 0.5 6.23 0.32 1.46e-9 Recombination rate (females); CRC cis rs7932354 0.528 rs12796744 chr11:47132724 A/T cg03339077 chr11:47165057 C11orf49 -0.44 -6.31 -0.33 9e-10 Bone mineral density (hip);Bone mineral density; CRC trans rs2383876 0.550 rs13278169 chr8:74067495 C/T cg23880589 chr17:7826623 KCNAB3 -0.36 -6.12 -0.32 2.67e-9 Corneal curvature; CRC cis rs780096 0.526 rs13391837 chr2:27649375 A/G cg12000995 chr2:27665139 KRTCAP3 -0.31 -6.25 -0.33 1.29e-9 Total body bone mineral density; CRC cis rs3768617 0.510 rs7529465 chr1:183096880 A/G ch.1.3577855R chr1:183094577 LAMC1 0.89 15.86 0.66 1.84e-42 Fuchs's corneal dystrophy; CRC cis rs853679 0.760 rs9295768 chr6:28209102 G/A cg25164649 chr6:28176230 NA 0.55 5.75 0.3 2e-8 Depression; CRC cis rs1799949 0.683 rs55737636 chr17:41264739 C/T cg23758822 chr17:41437982 NA 0.84 15.15 0.64 1.04e-39 Menopause (age at onset); CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg19161053 chr7:99036702 CPSF4;PTCD1 -0.5 -6.16 -0.32 2.06e-9 Diisocyanate-induced asthma; CRC cis rs6582630 0.519 rs11519914 chr12:38287014 A/G cg13010199 chr12:38710504 ALG10B 0.47 6.64 0.34 1.3100000000000001e-10 Drug-induced liver injury (flucloxacillin); CRC trans rs9929218 0.906 rs33965787 chr16:68828173 G/A cg04657470 chr2:198365150 HSPE1;HSPD1 -0.77 -11.12 -0.52 1.33e-24 Colorectal cancer; CRC cis rs116095464 0.558 rs61492827 chr5:225774 A/G cg22857025 chr5:266934 NA -1.22 -16.66 -0.68 1.26e-45 Breast cancer; CRC cis rs12137294 0.866 rs1078362 chr1:205209530 A/G cg24159697 chr1:205181237 DSTYK -0.34 -6.25 -0.33 1.31e-9 Red cell distribution width; CRC cis rs1050846 0.507 rs62053114 chr16:87423600 C/G cg27585878 chr16:87386489 FBXO31 -0.43 -6.87 -0.35 3.25e-11 Neuroticism; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg12078486 chr1:155108334 RAG1AP1 0.41 6.04 0.32 4.26e-9 Intelligence (multi-trait analysis); CRC cis rs9303280 0.868 rs11650661 chr17:38026286 A/T cg00129232 chr17:37814104 STARD3 -0.48 -7.76 -0.39 1.05e-13 Self-reported allergy; CRC cis rs4237845 0.844 rs4628718 chr12:58301600 A/C cg02175503 chr12:58329896 NA 0.57 7.6 0.39 3.08e-13 Intelligence (multi-trait analysis); CRC cis rs947211 1.000 rs947211 chr1:205752665 A/G cg24503407 chr1:205819492 PM20D1 0.45 6.18 0.32 1.91e-9 Parkinson's disease; CRC cis rs7107174 0.892 rs10899482 chr11:78060081 A/C cg02023728 chr11:77925099 USP35 0.49 8.44 0.42 1.05e-15 Testicular germ cell tumor; CRC cis rs7772486 0.720 rs6570713 chr6:146075085 G/A cg23711669 chr6:146136114 FBXO30 -0.74 -12.57 -0.57 7.4e-30 Lobe attachment (rater-scored or self-reported); CRC cis rs7647973 0.580 rs11130184 chr3:49229930 C/T cg06212747 chr3:49208901 KLHDC8B 0.38 5.76 0.3 1.97e-8 Menarche (age at onset); CRC cis rs4478858 0.684 rs1532861 chr1:31766491 T/C cg00250761 chr1:31883323 NA -0.44 -8.54 -0.43 5.19e-16 Alcohol dependence; CRC cis rs1707322 0.721 rs7519900 chr1:46234947 C/T cg06784218 chr1:46089804 CCDC17 0.65 11.94 0.55 1.56e-27 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC trans rs66759488 0.739 rs10851451 chr15:47608991 A/G cg10667969 chr3:149181941 NA -0.51 -7.08 -0.36 9e-12 Lung cancer; CRC cis rs4555082 0.834 rs1473672 chr14:105721981 G/T cg18132624 chr14:105716052 BTBD6;BRF1 -0.47 -7.45 -0.38 8.54e-13 Mean platelet volume;Platelet distribution width; CRC trans rs877282 0.891 rs11595385 chr10:800539 A/G cg22713356 chr15:30763199 NA 1.34 16.61 0.68 2.05e-45 Uric acid levels; CRC cis rs881375 0.934 rs1468671 chr9:123657502 C/G cg00246817 chr9:123691163 NA -0.47 -6.0 -0.31 5.15e-9 Rheumatoid arthritis; CRC cis rs12477438 0.520 rs2309581 chr2:99784292 A/G cg14399236 chr2:99771627 LIPT1;TSGA10 -0.78 -13.41 -0.59 5.34e-33 Chronic sinus infection; CRC cis rs875971 1.000 rs6460295 chr7:65882728 T/C cg18912574 chr7:65842487 NCRNA00174 0.36 6.18 0.32 1.88e-9 Aortic root size; CRC cis rs780096 0.526 rs4582 chr2:27604279 A/G cg02592271 chr2:27665507 KRTCAP3 -0.26 -5.93 -0.31 7.58e-9 Total body bone mineral density; CRC cis rs9467773 1.000 rs9461271 chr6:26554968 G/A cg09904177 chr6:26538194 HMGN4 0.85 14.85 0.63 1.61e-38 Intelligence (multi-trait analysis); CRC cis rs7131987 0.650 rs7954871 chr12:29459732 G/A cg09582351 chr12:29534625 ERGIC2 -0.34 -7.33 -0.37 1.8e-12 QT interval; CRC cis rs11809207 0.568 rs1892494 chr1:26497626 C/G cg00147160 chr1:26503991 CNKSR1 0.29 6.07 0.32 3.56e-9 Height; CRC cis rs3806843 0.576 rs246074 chr5:140307969 C/G cg19875535 chr5:140030758 IK 0.4 6.17 0.32 1.96e-9 Depressive symptoms (multi-trait analysis); CRC cis rs2289328 0.882 rs7164606 chr15:40645133 G/A cg13931752 chr15:40660718 DISP2 0.52 6.23 0.33 1.39e-9 Intelligence (multi-trait analysis);Cognitive ability;Cognitive ability (multi-trait analysis); CRC cis rs7827545 1.000 rs7832857 chr8:135565477 A/G cg07299736 chr8:135490787 ZFAT -0.37 -6.2 -0.32 1.73e-9 Hypertension (SNP x SNP interaction); CRC cis rs6815814 0.851 rs11466645 chr4:38778203 A/T cg06935464 chr4:38784597 TLR10 0.6 5.93 0.31 7.46e-9 Breast cancer; CRC cis rs35883536 0.967 rs4908085 chr1:101087901 C/G cg14515779 chr1:101123966 NA -0.45 -8.57 -0.43 3.95e-16 Monocyte count; CRC cis rs10227331 1.000 rs10227331 chr7:157294938 A/T cg06076350 chr7:157294107 NA 0.33 6.17 0.32 1.96e-9 Inattentive symptoms; CRC cis rs1506636 0.886 rs4731112 chr7:123269118 C/G cg03229431 chr7:123269106 ASB15 -0.84 -13.81 -0.61 1.53e-34 Plateletcrit;Platelet count; CRC trans rs11039798 0.623 rs635632 chr11:48399532 T/C cg03929089 chr4:120376271 NA -0.63 -6.58 -0.34 1.86e-10 Axial length; CRC cis rs17384381 1.000 rs12140457 chr1:85860170 G/A cg16011679 chr1:85725395 C1orf52 0.64 6.56 0.34 2.1e-10 Lobe attachment (rater-scored or self-reported); CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg01712016 chr3:13521531 HDAC11 0.41 6.12 0.32 2.62e-9 Intelligence (multi-trait analysis); CRC cis rs28386778 0.897 rs2727327 chr17:61923422 G/A cg06601766 chr17:61851465 DDX42;CCDC47 0.44 5.97 0.31 6.04e-9 Prudent dietary pattern; CRC cis rs9291683 0.588 rs13113730 chr4:10017628 C/T cg11266682 chr4:10021025 SLC2A9 0.54 11.57 0.54 3.2e-26 Bone mineral density; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg08990198 chr1:202318195 PPP1R12B 0.44 6.03 0.32 4.47e-9 Response to antipsychotic treatment; CRC cis rs4689388 0.782 rs4262051 chr4:6281775 G/A cg25554036 chr4:6271136 WFS1 0.55 8.9 0.44 3.76e-17 Type 2 diabetes and other traits;Type 2 diabetes; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg13410877 chr18:55712976 NEDD4L 0.49 6.67 0.35 1.06e-10 Thyroid stimulating hormone; CRC cis rs6951245 0.935 rs61910751 chr7:1097895 A/G cg03188948 chr7:1209495 NA 0.65 6.84 0.35 3.8e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs9659323 1.000 rs10923714 chr1:119512913 C/T cg26570165 chr1:119541833 NA -0.38 -6.41 -0.33 5.12e-10 Body mass index; CRC cis rs9296092 0.538 rs56205713 chr6:33517510 A/G cg13560919 chr6:33536144 NA -0.42 -5.9 -0.31 9.16e-9 Age at smoking initiation in chronic obstructive pulmonary disease; CRC cis rs12762955 0.561 rs7918118 chr10:1042823 C/A cg26597838 chr10:835615 NA -0.45 -6.09 -0.32 3.2e-9 Response to angiotensin II receptor blocker therapy; CRC cis rs10779751 0.762 rs3010222 chr1:11326922 T/C cg08854313 chr1:11322531 MTOR -0.42 -5.75 -0.3 2e-8 Body mass index; CRC cis rs6679356 0.624 rs7535591 chr1:67817147 T/C cg24364144 chr1:67875067 SERBP1 0.43 5.71 0.3 2.48e-8 Primary biliary cholangitis; CRC cis rs11585357 0.947 rs72646795 chr1:17612120 C/T cg08277548 chr1:17600880 PADI3 -0.84 -11.06 -0.52 2.15e-24 Hair shape; CRC cis rs11212617 1.000 rs680113 chr11:108165406 G/A cg01991180 chr11:108092276 ATM;NPAT 0.41 5.97 0.31 6.04e-9 Response to metformin in type 2 diabetes (glycemic); CRC cis rs10992471 0.702 rs10120915 chr9:95547725 A/C cg13798575 chr9:95087839 CENPP;NOL8 -0.42 -5.96 -0.31 6.55e-9 Visceral adipose tissue/subcutaneous adipose tissue ratio; CRC cis rs56114371 0.568 rs200468 chr6:27757855 C/G cg08798685 chr6:27730294 NA -0.49 -6.39 -0.33 5.62e-10 Breast cancer; CRC cis rs2549003 1.000 rs2070724 chr5:131822072 A/G cg21138405 chr5:131827807 IRF1 0.57 11.38 0.53 1.59e-25 Asthma (sex interaction); CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg09379601 chr19:12992224 DNASE2 0.46 6.51 0.34 2.73e-10 Response to antipsychotic treatment; CRC cis rs13392177 0.684 rs11682371 chr2:219079513 G/A cg04731861 chr2:219085781 ARPC2 0.33 6.57 0.34 1.94e-10 Pyoderma gangrenosum in inflammatory bowel disease; CRC cis rs7224685 0.501 rs781850 chr17:3957124 C/T cg09597638 chr17:3907349 NA -0.66 -11.73 -0.54 9.08e-27 Type 2 diabetes; CRC cis rs67311347 0.956 rs11714871 chr3:40428938 T/G cg24209194 chr3:40518798 ZNF619 0.42 6.42 0.33 4.76e-10 Renal cell carcinoma; CRC cis rs6840360 0.615 rs3828546 chr4:152679816 A/G cg09659197 chr4:152720779 NA 0.42 8.72 0.43 1.44e-16 Intelligence (multi-trait analysis); CRC cis rs2243480 1.000 rs2420171 chr7:65637760 T/C cg25985355 chr7:65971099 NA 0.52 6.01 0.31 4.92e-9 Diabetic kidney disease; CRC cis rs801193 1.000 rs1553609 chr7:66197139 T/C cg11764359 chr7:65958608 NA 0.54 8.26 0.41 3.49e-15 Aortic root size; CRC cis rs62244186 0.659 rs9850129 chr3:44532047 C/T cg18165381 chr3:44552316 NA -0.4 -5.9 -0.31 9.09e-9 Depressive symptoms; CRC trans rs1005277 0.579 rs2472174 chr10:38375382 A/G cg17830980 chr10:43048298 ZNF37B -0.58 -9.66 -0.47 1.39e-19 Extrinsic epigenetic age acceleration; CRC cis rs6860806 0.507 rs183898 chr5:131716902 C/G cg11843238 chr5:131593191 PDLIM4 -0.43 -7.35 -0.38 1.56e-12 Breast cancer; CRC trans rs9467711 0.606 rs28360517 chr6:26602453 A/G cg06606381 chr12:133084897 FBRSL1 -0.82 -6.37 -0.33 6.27e-10 Autism spectrum disorder or schizophrenia; CRC cis rs3733346 0.529 rs6842493 chr4:914638 T/C cg20456258 chr4:962124 DGKQ 0.28 5.76 0.3 1.95e-8 Sjögren's syndrome; CRC cis rs2739330 0.587 rs4820571 chr22:24242973 A/G cg24846343 chr22:24311635 DDTL 0.58 8.73 0.43 1.35e-16 Liver enzyme levels (gamma-glutamyl transferase); CRC cis rs7762018 1.000 rs11961560 chr6:170130121 T/C cg24289452 chr6:170231220 NA -0.58 -6.58 -0.34 1.81e-10 Thiazide-induced adverse metabolic effects in hypertensive patients; CRC cis rs6952808 0.692 rs11765549 chr7:2027311 G/T cg22963979 chr7:1858916 MAD1L1 -0.52 -7.41 -0.38 1.07e-12 Bipolar disorder and schizophrenia; CRC cis rs10782582 0.546 rs79652169 chr1:76233882 G/A cg05598546 chr1:76251766 SNORD45C;RABGGTB 0.44 5.78 0.3 1.72e-8 Daytime sleep phenotypes; CRC cis rs524281 0.861 rs10896087 chr11:65924549 A/G cg14036092 chr11:66035641 RAB1B -0.47 -5.71 -0.3 2.54e-8 Electroencephalogram traits; CRC trans rs1814175 0.817 rs4881627 chr11:49953955 C/A cg03929089 chr4:120376271 NA -0.94 -17.92 -0.7 1.32e-50 Height; CRC cis rs12142240 0.698 rs112068407 chr1:46822291 T/C cg14993813 chr1:46806288 NSUN4 -0.49 -6.22 -0.32 1.55e-9 Menopause (age at onset); CRC cis rs1878931 0.501 rs42329 chr16:3425524 G/A cg26668626 chr16:3451006 ZNF174;ZNF434 -0.69 -9.28 -0.46 2.26e-18 Body mass index (adult); CRC cis rs28386778 0.897 rs2036911 chr17:61794839 A/T cg25654072 chr17:61904446 PSMC5;FTSJ3 0.72 11.05 0.52 2.31e-24 Prudent dietary pattern; CRC trans rs67981189 0.593 rs221917 chr14:71590003 C/T cg00881440 chr7:2595255 C7orf27 -0.41 -5.96 -0.31 6.49e-9 Schizophrenia; CRC cis rs9393692 0.905 rs34916901 chr6:26286149 G/T cg13736514 chr6:26305472 NA -0.63 -11.78 -0.54 5.88e-27 Educational attainment; CRC cis rs11671005 0.695 rs8106061 chr19:58917990 G/C cg11952622 chr19:58962976 ZNF324B 0.66 9.16 0.45 5.75e-18 Mean platelet volume; CRC cis rs4716602 0.596 rs10244786 chr7:156157989 C/T cg16983916 chr7:156159713 NA -0.38 -6.79 -0.35 5.35e-11 Anti-saccade response; CRC cis rs9341808 0.718 rs3812121 chr6:80968727 A/G cg08355045 chr6:80787529 NA 0.42 6.78 0.35 5.73e-11 Sitting height ratio; CRC cis rs9311474 0.581 rs13621 chr3:52558133 T/C cg18404041 chr3:52824283 ITIH1 -0.33 -6.81 -0.35 4.6e-11 Electroencephalogram traits; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg26035463 chr12:117627651 FBXO21 0.5 6.72 0.35 7.82e-11 Thyroid stimulating hormone; CRC cis rs4563143 0.663 rs2218396 chr19:29236392 C/T cg12667521 chr19:29218732 NA 0.49 7.53 0.38 4.82e-13 Methadone dose in opioid dependence; CRC cis rs977987 0.806 rs4146809 chr16:75415775 A/G cg03315344 chr16:75512273 CHST6 -0.53 -8.99 -0.44 1.99e-17 Dupuytren's disease; CRC cis rs734999 0.588 rs10910098 chr1:2533250 C/A cg20673091 chr1:2541236 MMEL1 0.36 5.84 0.31 1.26e-8 Ulcerative colitis; CRC cis rs1223397 1.000 rs1223397 chr6:13270945 C/G cg20827128 chr6:13274284 PHACTR1 0.48 6.15 0.32 2.27e-9 Blood pressure; CRC cis rs1552244 0.748 rs113890152 chr3:10085986 A/G cg08888203 chr3:10149979 C3orf24 0.71 9.54 0.47 3.42e-19 Alzheimer's disease; CRC cis rs72615157 0.595 rs112241539 chr7:99847237 C/T cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.48 5.65 0.3 3.57e-8 Lung function (FEV1/FVC); CRC cis rs1799949 1.000 rs67060599 chr17:41255102 A/G cg25072359 chr17:41440525 NA 0.45 6.6 0.34 1.65e-10 Menopause (age at onset); CRC cis rs10979 1.000 rs9484769 chr6:143896719 A/G cg25407410 chr6:143891975 LOC285740 -0.84 -13.72 -0.6 3.53e-34 Hypospadias; CRC cis rs4713118 0.662 rs149948 chr6:27974817 C/G cg20615401 chr6:28092323 ZSCAN16 0.44 5.8 0.3 1.52e-8 Parkinson's disease; CRC cis rs1799949 0.965 rs4239149 chr17:41328095 A/G cg23758822 chr17:41437982 NA -0.94 -19.3 -0.73 4.91e-56 Menopause (age at onset); CRC cis rs244731 1.000 rs244730 chr5:176539212 A/G cg17509989 chr5:176798049 RGS14 -0.57 -8.04 -0.41 1.69e-14 Urate levels in lean individuals; CRC cis rs4862750 0.872 rs7671914 chr4:187878165 A/G cg27532560 chr4:187881888 NA -0.53 -9.66 -0.47 1.29e-19 Lobe attachment (rater-scored or self-reported); CRC cis rs7208859 0.673 rs423151 chr17:28952286 A/G cg01831904 chr17:28903510 LRRC37B2 -0.49 -6.12 -0.32 2.66e-9 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg21786873 chr4:4250096 TMEM128 0.4 6.02 0.31 4.61e-9 Intelligence (multi-trait analysis); CRC cis rs2243480 1.000 rs13247184 chr7:65358928 A/G cg25985355 chr7:65971099 NA -0.5 -5.69 -0.3 2.86e-8 Diabetic kidney disease; CRC cis rs9811920 0.638 rs796977 chr3:99549723 T/A cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G -0.46 -6.1 -0.32 2.92e-9 Axial length; CRC cis rs7312933 0.558 rs1796382 chr12:42840955 C/G cg19980929 chr12:42632907 YAF2 -0.4 -6.18 -0.32 1.86e-9 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); CRC cis rs908922 0.676 rs1123567 chr1:152516023 G/A cg23254163 chr1:152506842 NA 0.43 8.46 0.42 8.8e-16 Hair morphology; CRC cis rs7618915 0.501 rs3755798 chr3:52741160 G/A cg18099408 chr3:52552593 STAB1 -0.45 -7.53 -0.38 5.06e-13 Bipolar disorder; CRC cis rs753778 1.000 rs753778 chr8:142228909 G/A cg18755752 chr8:142205143 DENND3 -0.45 -6.44 -0.33 4.14e-10 Reticulocyte fraction of red cells;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; CRC cis rs12282928 0.959 rs871249 chr11:48284477 G/A cg20307385 chr11:47447363 PSMC3 0.48 5.98 0.31 5.86e-9 Migraine - clinic-based; CRC cis rs2032447 0.714 rs129129 chr6:25961029 A/G cg18357526 chr6:26021779 HIST1H4A 0.68 10.26 0.49 1.26e-21 Intelligence (multi-trait analysis); CRC cis rs1448094 0.648 rs10863093 chr12:86285792 T/G cg19622623 chr12:86230825 RASSF9 -0.4 -6.34 -0.33 7.41e-10 Major depressive disorder; CRC cis rs6089584 0.606 rs2296082 chr20:60573983 A/G cg23262073 chr20:60523788 NA -0.41 -7.1 -0.36 7.97e-12 Body mass index; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg07531158 chr16:29818226 MAZ 0.45 6.26 0.33 1.19e-9 Response to antipsychotic treatment; CRC cis rs4654899 0.758 rs6698462 chr1:21341293 G/C cg02927042 chr1:21476669 EIF4G3 -0.4 -6.34 -0.33 7.6e-10 Superior frontal gyrus grey matter volume; CRC cis rs2243480 0.706 rs6460257 chr7:65196780 C/T cg18252515 chr7:66147081 NA -0.94 -11.71 -0.54 1.06e-26 Diabetic kidney disease; CRC cis rs9381040 1.000 rs9381040 chr6:41154650 C/T cg03526776 chr6:41159608 TREML2 0.45 7.61 0.39 2.98e-13 Alzheimer's disease (late onset); CRC trans rs587242 0.866 rs12037267 chr1:96904093 C/T cg10631902 chr5:14652156 NA 0.44 6.84 0.35 3.84e-11 Body mass index (joint analysis main effects and physical activity interaction);Body mass index in physically inactive individuals;Body mass index; CRC cis rs11031096 0.542 rs2412338 chr11:3977521 G/T cg18678763 chr11:4115507 RRM1 -0.41 -6.85 -0.35 3.61e-11 Mean corpuscular volume;Mean corpuscular hemoglobin; CRC trans rs66887589 0.870 rs59590064 chr4:120539753 T/C cg25214090 chr10:38739885 LOC399744 -0.42 -6.53 -0.34 2.57e-10 Diastolic blood pressure; CRC cis rs780096 0.527 rs59644396 chr2:27646083 A/G cg02592271 chr2:27665507 KRTCAP3 -0.28 -6.44 -0.33 4.13e-10 Total body bone mineral density; CRC trans rs7829975 0.807 rs519019 chr8:8595104 A/T cg16141378 chr3:129829833 LOC729375 0.42 6.28 0.33 1.08e-9 Mood instability; CRC cis rs1348850 0.567 rs3770009 chr2:178536544 C/T cg22681709 chr2:178499509 PDE11A -0.46 -8.15 -0.41 7.61e-15 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs4665809 0.590 rs1469523 chr2:26474631 T/A cg26119090 chr2:26468346 HADHA;HADHB 1.06 15.53 0.65 3.62e-41 Gut microbiome composition (summer); CRC cis rs7772486 0.686 rs2072911 chr6:146056801 G/A cg23711669 chr6:146136114 FBXO30 -0.65 -10.72 -0.51 3.39e-23 Lobe attachment (rater-scored or self-reported); CRC cis rs10504229 0.610 rs6993531 chr8:58147283 A/G cg02290350 chr8:58132656 NA -0.53 -7.83 -0.4 6.55e-14 Developmental language disorder (linguistic errors); CRC cis rs853679 0.517 rs9393901 chr6:28136797 A/G cg06470822 chr6:28175283 NA 1.03 13.59 0.6 1.04e-33 Depression; CRC cis rs8177253 0.511 rs9830001 chr3:133433470 A/G cg11941060 chr3:133502564 NA 0.38 6.1 0.32 3e-9 Iron status biomarkers; CRC trans rs10504229 0.953 rs72650891 chr8:58179697 T/G cg04077850 chr5:125800366 GRAMD3 0.37 6.27 0.33 1.15e-9 Developmental language disorder (linguistic errors); CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg17524854 chr12:67663046 CAND1 -0.52 -6.45 -0.34 4e-10 Diisocyanate-induced asthma; CRC cis rs13392177 0.684 rs6720105 chr2:219080718 G/A cg00012203 chr2:219082015 ARPC2 -0.5 -7.28 -0.37 2.52e-12 Pyoderma gangrenosum in inflammatory bowel disease; CRC cis rs11212617 0.967 rs183460 chr11:108090710 A/C cg01991180 chr11:108092276 ATM;NPAT 0.46 6.61 0.34 1.6e-10 Response to metformin in type 2 diabetes (glycemic); CRC cis rs10207060 0.500 rs4380264 chr2:240699378 G/T cg07506560 chr2:240697449 NA 0.52 6.81 0.35 4.54e-11 Obesity-related traits; CRC cis rs2279817 0.954 rs12143113 chr1:18018857 T/C cg21791023 chr1:18019539 ARHGEF10L 0.56 6.67 0.35 1.07e-10 Neuroticism; CRC cis rs4862750 0.914 rs11943333 chr4:187872455 A/G cg27532560 chr4:187881888 NA -0.52 -9.21 -0.45 3.84e-18 Lobe attachment (rater-scored or self-reported); CRC cis rs6499255 0.951 rs11641233 chr16:69734563 C/T cg04110750 chr16:69646130 NFAT5 -0.51 -7.17 -0.37 4.89e-12 IgE levels; CRC cis rs10971721 0.822 rs72727332 chr9:33929477 A/G cg13495928 chr9:33750294 PRSS3 0.56 5.99 0.31 5.44e-9 Body mass index; CRC cis rs7760949 0.889 rs9396264 chr6:13930342 T/A cg27413430 chr6:13925136 RNF182 0.33 5.76 0.3 1.91e-8 Mean corpuscular hemoglobin concentration; CRC trans rs9747201 0.890 rs12946944 chr17:80061748 C/T cg07393940 chr7:158741817 NA -0.52 -7.41 -0.38 1.07e-12 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs62064224 0.553 rs9896320 chr17:30689814 G/A cg18200150 chr17:30822561 MYO1D 0.45 8.7 0.43 1.62e-16 Schizophrenia; CRC cis rs6088580 0.634 rs6059856 chr20:33057954 G/C cg24642439 chr20:33292090 TP53INP2 0.38 6.27 0.33 1.16e-9 Glomerular filtration rate (creatinine); CRC cis rs9733 0.596 rs11204687 chr1:150629880 C/A cg18016565 chr1:150552671 MCL1 0.46 6.74 0.35 6.91e-11 Tonsillectomy; CRC cis rs62244186 0.715 rs10212378 chr3:44667286 C/G cg10263370 chr3:44754102 ZNF502 -0.38 -6.41 -0.33 5.14e-10 Depressive symptoms; CRC cis rs4727027 1.000 rs4727027 chr7:148869277 C/T cg12479418 chr7:148823350 ZNF425;ZNF398 0.43 5.84 0.31 1.26e-8 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC cis rs9393777 0.777 rs35984974 chr6:27410422 G/A cg15845792 chr6:28175446 NA 0.83 6.55 0.34 2.23e-10 Intelligence (multi-trait analysis); CRC cis rs1577917 0.876 rs12201992 chr6:86618219 T/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.52 -6.78 -0.35 5.53e-11 Response to antipsychotic treatment; CRC cis rs4865169 0.811 rs6841086 chr4:57903268 A/G cg25525207 chr4:57843836 C4orf14;POLR2B -0.43 -6.06 -0.32 3.67e-9 Breast cancer; CRC cis rs769267 0.965 rs12460764 chr19:19431963 G/T cg01262667 chr19:19385393 TM6SF2 -0.37 -6.22 -0.32 1.51e-9 Tonsillectomy; CRC cis rs72634258 0.796 rs6703955 chr1:8165975 C/G cg26816564 chr1:7831052 VAMP3 -0.49 -5.93 -0.31 7.71e-9 Inflammatory bowel disease; CRC cis rs898097 0.528 rs2243523 chr17:80680449 G/T cg16060761 chr17:80687452 NA 0.4 6.2 0.32 1.69e-9 Breast cancer; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg04212884 chr16:67876131 CENPT;THAP11 0.46 6.67 0.35 1.09e-10 Intelligence (multi-trait analysis); CRC cis rs3751196 0.901 rs74524744 chr12:104191696 A/G cg02344784 chr12:104178138 NT5DC3 0.69 7.05 0.36 1.06e-11 Sense of smell; CRC cis rs9341808 0.667 rs742833 chr6:80921446 C/T cg08355045 chr6:80787529 NA 0.33 5.72 0.3 2.44e-8 Sitting height ratio; CRC cis rs11758351 0.734 rs56220351 chr6:26206884 A/G cg10723962 chr6:26240782 HIST1H4F -0.38 -6.07 -0.32 3.47e-9 Gout;Renal underexcretion gout; CRC cis rs7089973 0.872 rs34683721 chr10:116619849 G/A cg03647239 chr10:116582469 FAM160B1 0.41 5.79 0.3 1.67e-8 Bipolar disorder or attention deficit hyperactivity disorder; CRC cis rs6714710 0.603 rs13034929 chr2:98402772 G/C cg26665480 chr2:98280029 ACTR1B 0.55 7.35 0.38 1.61e-12 Posterior cortical atrophy and Alzheimer's disease; CRC cis rs11971779 0.680 rs7804388 chr7:139086413 A/G cg07862535 chr7:139043722 LUC7L2 0.57 7.35 0.38 1.61e-12 Diisocyanate-induced asthma; CRC cis rs344364 0.602 rs2437744 chr16:1908451 C/T cg09830162 chr16:1889614 FAHD1;C16orf73 0.56 8.3 0.42 2.66e-15 Glomerular filtration rate in chronic kidney disease; CRC cis rs8060686 0.641 rs113162813 chr16:68038969 A/G cg09835421 chr16:68378352 PRMT7 -0.56 -5.65 -0.3 3.39e-8 HDL cholesterol;Metabolic syndrome; CRC cis rs28386778 0.897 rs2727287 chr17:61904728 G/A cg25654072 chr17:61904446 PSMC5;FTSJ3 0.72 11.28 0.53 3.52e-25 Prudent dietary pattern; CRC cis rs1552244 1.000 rs113134644 chr3:10086286 G/A cg10729496 chr3:10149963 C3orf24 0.5 6.63 0.34 1.37e-10 Alzheimer's disease; CRC cis rs9914988 1.000 rs9895443 chr17:27182944 A/G cg20469991 chr17:27169893 C17orf63 -0.48 -5.99 -0.31 5.37e-9 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs9611565 0.512 rs2050031 chr22:42152266 A/G cg06481639 chr22:41940642 POLR3H 0.55 6.11 0.32 2.76e-9 Vitiligo; CRC cis rs6968419 0.585 rs9692117 chr7:115927959 G/T cg19719915 chr7:115928094 NA 0.42 6.78 0.35 5.68e-11 Intraocular pressure; CRC cis rs2832191 0.720 rs7277028 chr21:30494604 T/C cg24692254 chr21:30365293 RNF160 -0.69 -11.85 -0.55 3.36e-27 Dental caries; CRC trans rs7819412 0.594 rs7460507 chr8:10969075 C/T cg08975724 chr8:8085496 FLJ10661 -0.43 -6.26 -0.33 1.18e-9 Triglycerides; CRC cis rs896854 0.625 rs13281709 chr8:95972819 T/A cg16049864 chr8:95962084 TP53INP1 -0.65 -11.82 -0.55 4.04e-27 Type 2 diabetes; CRC cis rs7666738 0.830 rs13138438 chr4:99050545 C/A cg05340658 chr4:99064831 C4orf37 0.6 9.35 0.46 1.4e-18 Colonoscopy-negative controls vs population controls; CRC cis rs7552404 0.727 rs5745433 chr1:76333163 T/G cg10523679 chr1:76189770 ACADM 0.69 8.89 0.44 4.24e-17 Blood metabolite levels;Acylcarnitine levels; CRC cis rs7615952 0.576 rs2276727 chr3:125826243 C/T cg06494592 chr3:125709126 NA -0.54 -6.49 -0.34 3.14e-10 Blood pressure (smoking interaction); CRC cis rs7829975 0.711 rs4841051 chr8:8685646 C/T cg14979609 chr8:8086686 FLJ10661 0.38 6.46 0.34 3.79e-10 Mood instability; CRC trans rs916888 0.821 rs70600 chr17:44860021 C/T cg22968622 chr17:43663579 NA 1.3 17.02 0.68 5.1e-47 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs9399135 0.660 rs4472368 chr6:135274232 A/G cg22676075 chr6:135203613 NA 0.49 7.55 0.38 4.45e-13 Red blood cell count; CRC cis rs2239547 0.522 rs2564947 chr3:53046216 C/T cg11645453 chr3:52864694 ITIH4 -0.54 -10.17 -0.49 2.58e-21 Schizophrenia; CRC cis rs763014 0.932 rs35067229 chr16:649638 T/C cg04562611 chr16:615315 C16orf11 0.35 5.87 0.31 1.07e-8 Height; CRC cis rs9910055 0.529 rs183462 chr17:42183376 G/C cg13607699 chr17:42295918 UBTF -0.47 -6.2 -0.32 1.67e-9 Total body bone mineral density; CRC trans rs13046373 0.905 rs4816372 chr21:32077414 A/T cg18065981 chr2:242570529 THAP4 -0.41 -6.41 -0.33 5.16e-10 HDL cholesterol; CRC cis rs12908161 1.000 rs35960805 chr15:85343980 T/G cg17507749 chr15:85114479 UBE2QP1 0.6 8.59 0.43 3.61e-16 Schizophrenia; CRC cis rs6604026 0.656 rs9440134 chr1:93370813 C/T cg17283838 chr1:93427260 FAM69A -0.43 -5.79 -0.3 1.61e-8 Multiple sclerosis; CRC cis rs76878669 0.561 rs12420203 chr11:66163794 T/C cg18002602 chr11:66138449 SLC29A2 0.27 5.84 0.31 1.22e-8 Educational attainment (years of education); CRC cis rs13191362 1.000 rs34931503 chr6:163003876 T/C cg21926612 chr6:163149169 PACRG;PARK2 0.8 11.15 0.52 1.08e-24 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC trans rs7613875 0.620 rs17657664 chr3:50032008 T/G cg21665057 chr3:196295764 WDR53;FBXO45 0.44 6.35 0.33 6.99e-10 Body mass index; CRC cis rs6761276 0.899 rs12711750 chr2:113835380 C/A cg09040174 chr2:113837401 NA 0.65 10.31 0.49 9.07e-22 Protein quantitative trait loci; CRC cis rs3741404 0.620 rs11231722 chr11:63967770 C/G cg18225595 chr11:63971243 STIP1 0.54 8.82 0.44 6.96e-17 Platelet count; CRC trans rs10838798 0.523 rs11039543 chr11:48168103 G/A cg21153622 chr11:89784906 NA -0.46 -7.3 -0.37 2.22e-12 Height; CRC trans rs4263408 0.934 rs9683743 chr4:39703194 A/C cg12719510 chr1:155024394 ADAM15 -0.41 -6.1 -0.32 3e-9 Plasma amyloid beta peptide concentrations (ABx-40); CRC trans rs941408 0.515 rs12610096 chr19:2778129 C/T cg19676328 chr12:49525230 TUBA1B -0.48 -6.09 -0.32 3.21e-9 Total cholesterol levels; CRC cis rs1555322 0.530 rs932562 chr20:33871310 T/C cg03689076 chr20:33865952 NA 0.49 6.94 0.36 2.14e-11 Attention deficit hyperactivity disorder; CRC cis rs6582630 0.555 rs10880613 chr12:38509553 C/T cg26384229 chr12:38710491 ALG10B 0.71 9.54 0.47 3.27e-19 Drug-induced liver injury (flucloxacillin); CRC cis rs2580764 0.566 rs2972072 chr2:55295370 G/T cg09592903 chr2:55203963 RTN4 0.71 11.29 0.53 3.25e-25 Mean platelet volume; CRC cis rs17376456 0.825 rs10053405 chr5:93275403 A/G cg25358565 chr5:93447407 FAM172A -1.0 -10.22 -0.49 1.75e-21 Diabetic retinopathy; CRC cis rs1843834 0.505 rs2140508 chr2:225355839 G/T cg22455342 chr2:225449267 CUL3 0.65 8.52 0.43 5.72e-16 IgE levels in asthmatics (D.p. specific); CRC cis rs2839186 0.868 rs2839199 chr21:47708269 T/C cg02776659 chr21:47717406 C21orf57 -0.34 -5.62 -0.3 4.13e-8 Testicular germ cell tumor; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg05969063 chr14:70193782 NA 0.45 6.58 0.34 1.81e-10 Intelligence (multi-trait analysis); CRC cis rs6908034 0.607 rs79406203 chr6:19816221 T/G cg02682789 chr6:19804855 NA 0.81 6.48 0.34 3.35e-10 Endometriosis;Deep ovarian and/or rectovaginal disease with dense adhesions; CRC cis rs2243480 1.000 rs313814 chr7:65503293 C/A cg12463550 chr7:65579703 CRCP 0.75 6.82 0.35 4.5e-11 Diabetic kidney disease; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg05021743 chr1:151810893 C2CD4D;LOC100132111 0.25 7.18 0.37 4.8e-12 Liver disease severity in Alagille syndrome; CRC cis rs7107174 0.892 rs2510033 chr11:77941771 T/G cg02023728 chr11:77925099 USP35 0.51 7.48 0.38 6.68e-13 Testicular germ cell tumor; CRC trans rs6762477 0.748 rs11711407 chr3:50225029 A/G cg21659725 chr3:3221576 CRBN -0.42 -6.35 -0.33 7.2e-10 Menarche (age at onset); CRC trans rs877282 0.838 rs11253408 chr10:796374 T/C cg22713356 chr15:30763199 NA 1.34 16.68 0.68 1.08e-45 Uric acid levels; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg01587390 chr19:10221818 PPAN-P2RY11;P2RY11;PPAN -0.4 -6.5 -0.34 2.97e-10 Liver disease severity in Alagille syndrome; CRC cis rs7539624 0.588 rs28370014 chr1:223903167 A/G cg10100437 chr1:223903862 CAPN2 0.44 6.27 0.33 1.15e-9 Schizophrenia; CRC cis rs763121 0.853 rs138702 chr22:39132601 A/T cg06544989 chr22:39130855 UNC84B -0.46 -7.33 -0.37 1.81e-12 Menopause (age at onset); CRC cis rs4555082 0.957 rs2816627 chr14:105736109 A/G cg18132624 chr14:105716052 BTBD6;BRF1 -0.43 -7.14 -0.37 6.11e-12 Mean platelet volume;Platelet distribution width; CRC cis rs9549367 0.713 rs553316 chr13:113838015 A/G cg00898013 chr13:113819073 PROZ 0.5 7.43 0.38 9.39e-13 Platelet distribution width; CRC cis rs6502050 0.769 rs9898542 chr17:80119682 C/T cg19223190 chr17:80058835 NA 0.39 6.23 0.32 1.43e-9 Life satisfaction; CRC cis rs6456156 0.792 rs7775443 chr6:167513252 A/C cg07741184 chr6:167504864 NA -0.49 -8.55 -0.43 4.64e-16 Primary biliary cholangitis; CRC cis rs28386778 1.000 rs2955241 chr17:61968113 G/C cg25654072 chr17:61904446 PSMC5;FTSJ3 0.68 10.06 0.48 6.32e-21 Prudent dietary pattern; CRC cis rs977987 0.778 rs11858992 chr16:75411445 A/C cg03315344 chr16:75512273 CHST6 0.53 8.85 0.44 5.48e-17 Dupuytren's disease; CRC cis rs1150668 0.699 rs1531681 chr6:28226878 A/G cg21251018 chr6:28226885 NKAPL 0.64 12.1 0.55 4.06e-28 Pubertal anthropometrics; CRC cis rs59104589 0.521 rs886809 chr2:242397460 A/G cg19488206 chr2:242435732 STK25 0.49 7.77 0.39 1.03e-13 Fibrinogen levels; CRC cis rs637571 0.522 rs12792888 chr11:65761446 C/T cg26695010 chr11:65641043 EFEMP2 -0.41 -5.99 -0.31 5.44e-9 Eosinophil percentage of white cells; CRC cis rs13144136 0.687 rs6850317 chr4:10664294 T/C cg10242279 chr4:10666415 CLNK -0.38 -6.48 -0.34 3.41e-10 Resistance to antihypertensive treatment in hypertension; CRC cis rs1008375 1.000 rs11724495 chr4:17621310 G/A cg04450456 chr4:17643702 FAM184B 0.41 6.6 0.34 1.6e-10 Parasitemia in Tripanosoma cruzi seropositivity; CRC cis rs6585424 1.000 rs34100029 chr10:81923598 C/G cg11900509 chr10:81946545 ANXA11 -0.72 -8.81 -0.44 7.22e-17 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs2304069 0.545 rs6866616 chr5:149415401 A/G cg12661370 chr5:149340060 SLC26A2 0.45 6.44 0.33 4.12e-10 HIV-1 control; CRC cis rs10078 0.571 rs2721014 chr5:463539 G/A cg26072250 chr5:443457 EXOC3;C5orf55 0.58 5.78 0.3 1.72e-8 Fat distribution (HIV); CRC cis rs7591163 1.000 rs1039665 chr2:228717392 A/G cg20647610 chr2:228736258 WDR69 -0.5 -6.78 -0.35 5.7e-11 Blood pressure; CRC cis rs7586879 0.639 rs2033654 chr2:25103108 C/A cg04586622 chr2:25135609 ADCY3 -0.54 -9.94 -0.48 1.55e-20 Body mass index; CRC cis rs7493 0.901 rs11764079 chr7:95026229 A/G cg17330251 chr7:94953956 PON1 0.48 7.08 0.36 8.93e-12 Yu-Zhi constitution type in type 2 diabetes; CRC cis rs7727544 0.570 rs7701237 chr5:131534381 C/T cg02033258 chr5:131593261 PDLIM4 0.32 5.86 0.31 1.15e-8 Blood metabolite levels; CRC cis rs1656402 0.906 rs883803 chr2:233458453 C/T cg03852847 chr2:233439513 NA 0.36 6.17 0.32 2e-9 Non-small cell lung cancer (survival); CRC cis rs6952808 0.789 rs35729895 chr7:1885069 C/T cg22963979 chr7:1858916 MAD1L1 -0.58 -9.2 -0.45 4.31e-18 Bipolar disorder and schizophrenia; CRC trans rs61931739 0.534 rs11053029 chr12:34131766 G/T cg26384229 chr12:38710491 ALG10B 0.52 6.85 0.35 3.62e-11 Morning vs. evening chronotype; CRC trans rs478304 0.593 rs9666878 chr11:65475816 A/C cg17712092 chr4:129076599 LARP1B 0.42 6.15 0.32 2.31e-9 Acne (severe); CRC cis rs7089973 0.604 rs11196952 chr10:116607592 G/A cg23260525 chr10:116636907 FAM160B1 0.35 8.11 0.41 1.04e-14 Bipolar disorder or attention deficit hyperactivity disorder; CRC cis rs4319547 0.656 rs2173582 chr12:122824694 A/G cg23029597 chr12:123009494 RSRC2 -0.5 -6.2 -0.32 1.73e-9 Body mass index; CRC cis rs35146811 0.961 rs1880949 chr7:99722266 A/C cg03265037 chr7:99691720 MIR25;MCM7;MIR106B;MIR93 -0.45 -5.68 -0.3 2.93e-8 Coronary artery disease; CRC cis rs13082711 0.863 rs36055621 chr3:27436797 T/C cg02860705 chr3:27208620 NA 0.6 8.69 0.43 1.69e-16 Systolic blood pressure;Diastolic blood pressure;Blood pressure; CRC cis rs875971 1.000 rs778696 chr7:65870813 C/G cg18876405 chr7:65276391 NA 0.52 9.04 0.45 1.37e-17 Aortic root size; CRC cis rs10193935 0.901 rs7570083 chr2:42517859 G/A cg27598129 chr2:42591480 NA -0.53 -6.68 -0.35 1.04e-10 Colonoscopy-negative controls vs population controls; CRC cis rs13191362 0.935 rs35446205 chr6:162938769 C/G cg06582575 chr6:163149167 PACRG;PARK2 0.78 9.3 0.46 1.98e-18 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs66573146 0.831 rs67602077 chr4:7024244 A/G cg00086871 chr4:6988644 TBC1D14 0.88 6.52 0.34 2.66e-10 Granulocyte percentage of myeloid white cells; CRC cis rs1218582 0.772 rs10908445 chr1:154849590 A/G cg24250549 chr1:154909240 PMVK -0.62 -10.32 -0.49 8.39e-22 Prostate cancer; CRC cis rs6598955 0.724 rs10902737 chr1:26635716 G/A cg04990556 chr1:26633338 UBXN11 -0.76 -12.27 -0.56 9.7e-29 Obesity-related traits; CRC cis rs929596 0.793 rs2741045 chr2:234580140 C/T cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.54 -7.61 -0.39 2.99e-13 Total bilirubin levels in HIV-1 infection; CRC cis rs4700695 0.841 rs251305 chr5:65249859 C/T cg21114390 chr5:65439923 SFRS12 0.5 6.21 0.32 1.57e-9 Facial morphology (factor 19); CRC cis rs796364 0.806 rs1106400 chr2:201004089 T/C cg23649088 chr2:200775458 C2orf69 -0.58 -5.91 -0.31 8.54e-9 Schizophrenia; CRC cis rs11123170 0.640 rs2863240 chr2:113970116 C/T cg19083407 chr2:113993142 PAX8;LOC440839;LOC654433 -0.52 -6.82 -0.35 4.41e-11 Renal function-related traits (BUN); CRC cis rs2239547 0.563 rs9876403 chr3:52916916 C/T cg18404041 chr3:52824283 ITIH1 -0.37 -7.03 -0.36 1.2e-11 Schizophrenia; CRC cis rs950169 1.000 rs62026530 chr15:84775840 G/T cg17507749 chr15:85114479 UBE2QP1 0.77 11.97 0.55 1.2100000000000001e-27 Schizophrenia; CRC cis rs7726839 0.540 rs58599998 chr5:596087 A/G cg16447950 chr5:562315 NA -0.73 -9.65 -0.47 1.41e-19 Obesity-related traits; CRC cis rs4713118 0.662 rs469228 chr6:27970704 A/G cg23161317 chr6:28129485 ZNF389 0.47 6.64 0.34 1.28e-10 Parkinson's disease; CRC cis rs7131987 0.650 rs7301398 chr12:29455390 G/T cg09582351 chr12:29534625 ERGIC2 -0.33 -7.11 -0.37 7.16e-12 QT interval; CRC trans rs10155879 0.505 rs12704265 chr7:86142678 A/G cg02837488 chr7:73868870 GTF2IRD1 0.54 6.23 0.32 1.47e-9 Interleukin-4 levels; CRC cis rs6163 0.588 rs12763284 chr10:104508202 C/T cg11453585 chr10:104263688 ACTR1A;SUFU 0.52 8.17 0.41 6.83e-15 Waist circumference;Hip circumference; CRC trans rs11071559 0.526 rs1963497 chr15:61071791 A/C cg27220968 chr7:100493724 ACHE -0.41 -5.99 -0.31 5.48e-9 Asthma; CRC cis rs875971 0.862 rs801204 chr7:66022921 T/C cg12463550 chr7:65579703 CRCP -0.47 -6.46 -0.34 3.85e-10 Aortic root size; CRC trans rs10504229 1.000 rs67243305 chr8:58174958 G/A cg04077850 chr5:125800366 GRAMD3 0.38 6.39 0.33 5.59e-10 Developmental language disorder (linguistic errors); CRC cis rs6964587 0.967 rs10248102 chr7:91699779 G/A cg17063962 chr7:91808500 NA 0.8 14.04 0.61 1.97e-35 Breast cancer; CRC cis rs1552172 0.887 rs1471629 chr1:145707240 C/A cg11743829 chr1:145714124 CD160 -0.41 -6.09 -0.32 3.19e-9 Breast cancer; CRC cis rs6570726 0.935 rs434298 chr6:145846873 G/A cg23711669 chr6:146136114 FBXO30 0.69 12.25 0.56 1.1e-28 Lobe attachment (rater-scored or self-reported); CRC trans rs11148252 0.508 rs6561671 chr13:53182314 G/A cg18335740 chr13:41363409 SLC25A15 0.77 13.72 0.6 3.44e-34 Lewy body disease; CRC cis rs9549260 0.816 rs7337995 chr13:41249040 A/G cg21288729 chr13:41239152 FOXO1 0.44 6.64 0.34 1.34e-10 Red blood cell count; CRC cis rs4478858 0.735 rs10798843 chr1:31797094 A/G cg00250761 chr1:31883323 NA -0.44 -8.5 -0.42 6.71e-16 Alcohol dependence; CRC cis rs7666738 0.830 rs13102369 chr4:99045912 A/G cg17366294 chr4:99064904 C4orf37 0.45 7.75 0.39 1.16e-13 Colonoscopy-negative controls vs population controls; CRC cis rs11148252 0.532 rs9526975 chr13:53255804 C/T cg20354231 chr13:53171401 NA -0.52 -8.17 -0.41 6.74e-15 Lewy body disease; CRC cis rs4665809 0.627 rs13032756 chr2:26489730 A/T cg22920501 chr2:26401640 FAM59B 0.84 12.24 0.56 1.22e-28 Gut microbiome composition (summer); CRC cis rs28386778 0.863 rs2597633 chr17:61872871 T/C cg11494091 chr17:61959527 GH2 0.59 10.03 0.48 7.61e-21 Prudent dietary pattern; CRC cis rs73206853 0.841 rs56887341 chr12:110947185 T/C cg12870014 chr12:110450643 ANKRD13A 0.81 9.5 0.46 4.54e-19 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); CRC trans rs6703335 0.870 rs10803142 chr1:243598234 A/G cg17939434 chr2:96931590 CIAO1;TMEM127 0.44 6.19 0.32 1.83e-9 Schizophrenia;Schizophrenia, schizoaffective disorder or bipolar disorder; CRC cis rs62432291 0.681 rs388001 chr6:159658459 C/T cg14500486 chr6:159655392 FNDC1 -0.77 -10.43 -0.5 3.48e-22 Joint mobility (Beighton score); CRC cis rs2033711 0.840 rs4801590 chr19:58961813 G/C cg13877915 chr19:58951672 ZNF132 0.48 7.74 0.39 1.21e-13 Uric acid clearance; CRC cis rs10504229 0.610 rs6993531 chr8:58147283 A/G cg22535103 chr8:58192502 C8orf71 -0.66 -9.45 -0.46 6.59e-19 Developmental language disorder (linguistic errors); CRC cis rs10876993 0.890 rs115106209 chr12:58059331 G/A cg18357645 chr12:58087776 OS9 0.57 7.95 0.4 2.99e-14 Celiac disease or Rheumatoid arthritis; CRC cis rs853679 0.517 rs9348793 chr6:28084189 G/A cg12273811 chr6:28175739 NA 0.73 9.18 0.45 4.85e-18 Depression; CRC cis rs1572438 1.000 rs9379167 chr6:866372 C/T cg13447295 chr6:887704 NA -0.5 -6.92 -0.36 2.3e-11 Aging; CRC cis rs13108904 0.557 rs1680033 chr4:1243404 C/T cg05025164 chr4:1340916 KIAA1530 -0.49 -6.8 -0.35 4.93e-11 Obesity-related traits; CRC cis rs1046896 1.000 rs1046917 chr17:80685655 A/G cg17346650 chr17:80929145 B3GNTL1 -0.36 -5.88 -0.31 9.87e-9 Glycated hemoglobin levels; CRC cis rs4253772 0.591 rs9627324 chr22:46656511 A/G cg24881330 chr22:46731750 TRMU 0.6 7.07 0.36 9.23e-12 LDL cholesterol;Cholesterol, total; CRC trans rs35110281 0.837 rs2838343 chr21:45078035 C/T cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.43 6.98 0.36 1.6e-11 Mean corpuscular volume; CRC cis rs1045714 0.895 rs2293405 chr7:2644607 G/T cg24848437 chr7:2645542 IQCE 0.59 6.12 0.32 2.66e-9 Urate levels in lean individuals; CRC cis rs4664304 0.802 rs3749114 chr2:160832996 A/T cg03641300 chr2:160917029 PLA2R1 -0.46 -6.51 -0.34 2.82e-10 Crohn's disease;Inflammatory bowel disease; CRC cis rs2019137 0.560 rs10206269 chr2:113990393 C/A cg23564664 chr2:113997917 PAX8;LOC654433;LOC440839 -0.36 -5.79 -0.3 1.63e-8 Lymphocyte counts; CRC cis rs13108904 0.901 rs7673398 chr4:1300077 G/A cg19318889 chr4:1322082 MAEA 0.41 6.3 0.33 9.63e-10 Obesity-related traits; CRC cis rs7224685 0.501 rs6502770 chr17:4007314 A/G cg09695851 chr17:3907499 NA 0.65 11.44 0.53 1e-25 Type 2 diabetes; CRC trans rs559356 0.561 rs511922 chr3:34834934 C/T cg19071035 chr6:20404090 E2F3 0.46 6.0 0.31 5.29e-9 Cognitive function; CRC trans rs16846053 0.786 rs72873607 chr2:162471174 G/A cg18122310 chr12:50236657 BCDIN3D -0.73 -6.17 -0.32 2.02e-9 Blood osmolality (transformed sodium); CRC trans rs2303319 0.504 rs72877343 chr2:162607487 A/C cg22902534 chr3:183892754 AP2M1 -0.7 -6.1 -0.32 2.96e-9 Cognitive function; CRC trans rs7615952 0.512 rs11921452 chr3:125359750 A/G cg02007433 chr3:129722099 NA -0.61 -9.23 -0.45 3.33e-18 Blood pressure (smoking interaction); CRC cis rs2243480 1.000 rs1638734 chr7:66097539 A/C cg12463550 chr7:65579703 CRCP 0.63 5.72 0.3 2.34e-8 Diabetic kidney disease; CRC cis rs17270561 0.609 rs2000351 chr6:25759783 T/C cg16482183 chr6:26056742 HIST1H1C 0.71 9.0 0.44 1.79e-17 Iron status biomarkers; CRC cis rs4975709 0.610 rs4975705 chr5:1860359 T/C cg11168104 chr5:1857477 NA -0.38 -6.59 -0.34 1.79e-10 Cardiovascular disease risk factors; CRC cis rs35883536 0.708 rs34689792 chr1:101097753 A/G cg14515779 chr1:101123966 NA -0.43 -8.22 -0.41 4.84e-15 Monocyte count; CRC cis rs7249142 0.562 rs2239370 chr19:19292674 T/C cg12558012 chr19:19281197 LOC729991-MEF2B;MEF2B 0.55 8.6 0.43 3.22e-16 IgG glycosylation; CRC cis rs10540 1.000 rs67912009 chr11:495057 G/T cg19913688 chr11:428466 ANO9 -0.56 -6.11 -0.32 2.88e-9 Body mass index; CRC cis rs58365266 1.000 rs58365266 chr3:195813757 C/T cg01181863 chr3:195395398 SDHAP2 -0.59 -6.2 -0.32 1.67e-9 Red cell distribution width; CRC cis rs2836974 0.932 rs2234543 chr21:40572072 G/A cg11644478 chr21:40555479 PSMG1 0.81 12.33 0.56 5.83e-29 Cognitive function; CRC cis rs7246657 0.943 rs2303131 chr19:37936025 G/A cg23950597 chr19:37808831 NA -0.54 -6.46 -0.34 3.68e-10 Coronary artery calcification; CRC trans rs9858542 0.953 rs10640 chr3:49454277 G/A cg21665057 chr3:196295764 WDR53;FBXO45 -0.62 -8.44 -0.42 1e-15 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs936229 0.861 rs12441505 chr15:75107311 A/C cg10253484 chr15:75165896 SCAMP2 -0.4 -5.86 -0.31 1.13e-8 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); CRC cis rs6831352 0.918 rs29001211 chr4:100051941 C/T cg13256891 chr4:100009986 ADH5 -0.65 -8.86 -0.44 5.21e-17 Alcohol dependence; CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg12568633 chr10:73533407 CDH23;C10orf54 0.42 7.04 0.36 1.09e-11 Obesity-related traits; CRC cis rs7618915 0.508 rs12498066 chr3:52627660 G/A cg08222913 chr3:52553049 STAB1 -0.34 -6.21 -0.32 1.64e-9 Bipolar disorder; CRC cis rs11190604 0.767 rs872290 chr10:102198879 G/A cg07080220 chr10:102295463 HIF1AN 0.51 6.36 0.33 6.76e-10 Palmitoleic acid (16:1n-7) levels; CRC cis rs3749237 0.595 rs11130196 chr3:49490149 A/C cg07636037 chr3:49044803 WDR6 0.55 8.1 0.41 1.05e-14 Resting heart rate; CRC cis rs916888 0.773 rs199534 chr17:44824213 T/G cg01570182 chr17:44337453 NA 1.3 14.37 0.62 1.07e-36 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs6951245 0.554 rs4724294 chr7:1139695 G/A cg18402987 chr7:1209562 NA 0.52 6.3 0.33 9.68e-10 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs1555895 0.611 rs2892159 chr10:855061 G/A cg10556349 chr10:835070 NA -0.35 -6.73 -0.35 7.63e-11 Survival in rectal cancer; CRC cis rs921968 0.565 rs11896209 chr2:219599268 C/T cg02176678 chr2:219576539 TTLL4 -0.39 -6.17 -0.32 1.97e-9 Mean corpuscular hemoglobin concentration; CRC cis rs67478160 0.643 rs4900594 chr14:104251006 C/T cg08213375 chr14:104286397 PPP1R13B 0.67 13.96 0.61 4.12e-35 Schizophrenia; CRC cis rs17713451 0.593 rs112258991 chr7:151270296 T/C cg18404559 chr7:151322523 PRKAG2 -0.57 -6.41 -0.33 5.12e-10 Interleukin-4 levels; CRC cis rs595982 0.559 rs4802516 chr19:49366170 T/C cg21252483 chr19:49399788 TULP2 -0.37 -6.06 -0.32 3.77e-9 Red cell distribution width; CRC cis rs1150668 0.796 rs2247002 chr6:28397951 G/C cg06470822 chr6:28175283 NA 0.51 7.53 0.38 4.92e-13 Pubertal anthropometrics; CRC cis rs9486719 0.948 rs11152970 chr6:96909077 A/G cg06623918 chr6:96969491 KIAA0776 -0.79 -9.26 -0.45 2.81e-18 Migraine;Coronary artery disease; CRC cis rs8180040 0.620 rs9845728 chr3:47103376 C/T cg02527881 chr3:46936655 PTH1R -0.34 -5.92 -0.31 7.94e-9 Colorectal cancer; CRC cis rs1760803 0.754 rs2879788 chr1:154204310 A/T cg26808167 chr1:154192205 UBAP2L;C1orf43 -0.37 -6.35 -0.33 7.04e-10 Nicotine dependence; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg19268579 chr10:43904406 HNRNPF 0.37 6.2 0.32 1.65e-9 Liver disease severity in Alagille syndrome; CRC cis rs6089584 0.850 rs6142938 chr20:60627723 A/C cg06108461 chr20:60628389 TAF4 -0.91 -15.67 -0.65 9.55e-42 Body mass index; CRC cis rs7647973 0.516 rs4308307 chr3:49193216 C/T cg06212747 chr3:49208901 KLHDC8B 0.38 5.75 0.3 2.02e-8 Menarche (age at onset); CRC trans rs66573146 0.831 rs66645969 chr4:6985614 G/A cg07817883 chr1:32538562 TMEM39B 1.33 12.72 0.57 2.04e-30 Granulocyte percentage of myeloid white cells; CRC cis rs7635838 0.963 rs7627171 chr3:11413429 G/C cg00170343 chr3:11313890 ATG7 0.42 6.37 0.33 6.28e-10 HDL cholesterol; CRC cis rs4974559 0.739 rs2335937 chr4:1321516 C/A cg02980000 chr4:1222292 CTBP1 0.78 8.68 0.43 1.91e-16 Systolic blood pressure; CRC cis rs2991971 0.869 rs2453404 chr1:46014735 A/G cg24296786 chr1:45957014 TESK2 0.49 7.1 0.36 7.64e-12 High light scatter reticulocyte count; CRC cis rs77861329 1.000 rs9809254 chr3:52111474 T/C cg08692210 chr3:52188851 WDR51A 0.85 8.08 0.41 1.21e-14 Macrophage inflammatory protein 1b levels; CRC cis rs780096 0.506 rs1262430 chr2:27673798 T/C cg12000995 chr2:27665139 KRTCAP3 -0.32 -6.79 -0.35 5.1e-11 Total body bone mineral density; CRC cis rs7264396 0.563 rs6058302 chr20:34290037 C/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.49 -6.97 -0.36 1.7e-11 Total cholesterol levels; CRC cis rs4743820 0.590 rs73650935 chr9:93917658 T/C cg14446406 chr9:93919335 NA 0.77 13.61 0.6 9.16e-34 Ulcerative colitis;Inflammatory bowel disease; CRC cis rs7178572 0.524 rs7163503 chr15:77493505 C/A cg22256960 chr15:77711686 NA -0.67 -9.56 -0.47 2.93e-19 Type 2 diabetes; CRC cis rs2985684 1.000 rs2985696 chr14:50094913 C/A cg23565292 chr14:50234668 KLHDC2 -0.4 -5.62 -0.3 4.06e-8 Carotid intima media thickness; CRC cis rs1881797 1.000 rs66845073 chr1:247688010 C/T cg21399703 chr1:247681439 NA 0.46 7.61 0.39 2.97e-13 Acute lymphoblastic leukemia (childhood); CRC trans rs66887589 0.934 rs7681980 chr4:120533223 G/A cg25214090 chr10:38739885 LOC399744 -0.43 -6.7 -0.35 9.26e-11 Diastolic blood pressure; CRC cis rs7666738 0.791 rs2865953 chr4:99040319 C/T cg05340658 chr4:99064831 C4orf37 0.61 9.56 0.47 2.87e-19 Colonoscopy-negative controls vs population controls; CRC cis rs775227 0.574 rs2018912 chr3:113060140 A/G cg18753928 chr3:113234510 CCDC52 -0.55 -6.71 -0.35 8.75e-11 Dental caries; CRC cis rs4975709 0.589 rs4975744 chr5:1860049 A/G cg20790798 chr5:1857306 NA -0.45 -6.87 -0.35 3.14e-11 Cardiovascular disease risk factors; CRC cis rs6743376 0.556 rs1374285 chr2:113818738 G/A cg09040174 chr2:113837401 NA 0.44 6.44 0.33 4.3e-10 Inflammatory biomarkers; CRC cis rs651907 0.557 rs12629954 chr3:101360623 C/A cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.63 8.34 0.42 2e-15 Colorectal cancer; CRC cis rs2836950 0.501 rs2836984 chr21:40700949 A/C cg17971929 chr21:40555470 PSMG1 -0.52 -7.43 -0.38 9.59e-13 Menarche (age at onset); CRC trans rs2797160 1.000 rs6904069 chr6:125995134 C/T cg05039488 chr6:79577232 IRAK1BP1 -0.49 -7.36 -0.38 1.5e-12 Endometrial cancer; CRC trans rs2727020 0.612 rs9787891 chr11:49413494 G/A cg03929089 chr4:120376271 NA -0.8 -11.46 -0.53 8.11e-26 Coronary artery disease; CRC cis rs7605827 0.930 rs2111451 chr2:15654483 T/C cg19274914 chr2:15703543 NA 0.38 5.78 0.3 1.71e-8 Educational attainment (years of education); CRC cis rs2019137 0.936 rs902696 chr2:113954879 G/T cg07772999 chr2:113993052 PAX8;LOC440839;LOC654433 0.44 6.24 0.33 1.35e-9 Lymphocyte counts; CRC cis rs1348850 0.526 rs2218575 chr2:178368997 C/A cg27490568 chr2:178487706 NA 0.57 7.07 0.36 9.44e-12 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs3809863 0.602 rs7225700 chr17:45391804 T/C cg08085267 chr17:45401833 C17orf57 -0.79 -12.8 -0.58 1.0500000000000001e-30 Glaucoma (primary open-angle); CRC cis rs8040855 0.597 rs994989 chr15:85660716 G/C cg10818794 chr15:86012489 AKAP13 -0.44 -5.68 -0.3 2.93e-8 Bulimia nervosa; CRC cis rs6679356 0.789 rs10889681 chr1:67799170 T/C cg24364144 chr1:67875067 SERBP1 0.4 5.63 0.3 3.94e-8 Primary biliary cholangitis; CRC cis rs9309473 0.607 rs7560272 chr2:73561485 A/T cg20560298 chr2:73613845 ALMS1 -0.44 -5.92 -0.31 7.98e-9 Metabolite levels; CRC trans rs72991 0.556 rs297489 chr11:121256366 C/T cg27192990 chr6:129479024 LAMA2 -0.37 -6.08 -0.32 3.28e-9 Response to tocilizumab in rheumatoid arthritis; CRC cis rs11252926 0.599 rs11252213 chr10:454694 C/T cg16386425 chr10:429943 DIP2C -0.45 -7.02 -0.36 1.29e-11 Psychosis in Alzheimer's disease; CRC cis rs12586317 0.586 rs2295103 chr14:35515920 C/G cg05294307 chr14:35346193 BAZ1A -0.7 -7.83 -0.4 6.55e-14 Psoriasis; CRC cis rs9527 0.640 rs35195396 chr10:104928770 T/A cg04362960 chr10:104952993 NT5C2 0.61 8.4 0.42 1.37e-15 Arsenic metabolism; CRC cis rs6693567 0.565 rs696617 chr1:150376311 G/T cg04165759 chr1:150448943 RPRD2 0.36 5.86 0.31 1.15e-8 Migraine; CRC cis rs2839186 0.739 rs2280958 chr21:47642016 C/T cg13012494 chr21:47604986 C21orf56 0.46 7.26 0.37 2.86e-12 Testicular germ cell tumor; CRC cis rs7408868 0.572 rs2074616 chr19:15294991 C/T cg14696996 chr19:15285081 NOTCH3 0.6 6.83 0.35 4.2e-11 Pulse pressure; CRC cis rs68170813 0.559 rs2299422 chr7:106959832 A/T cg02696742 chr7:106810147 HBP1 -0.57 -6.31 -0.33 8.9e-10 Coronary artery disease; CRC cis rs17095355 1.000 rs734164 chr10:111698160 C/T cg00817464 chr10:111662876 XPNPEP1 -0.61 -8.32 -0.42 2.33e-15 Biliary atresia; CRC cis rs6952808 0.529 rs73038442 chr7:2139457 C/T cg22963979 chr7:1858916 MAD1L1 -0.46 -6.63 -0.34 1.36e-10 Bipolar disorder and schizophrenia; CRC cis rs3806843 1.000 rs12717860 chr5:140171442 C/T cg16607685 chr5:140181889 PCDHA2;PCDHA1;PCDHA3 -0.25 -5.65 -0.3 3.47e-8 Depressive symptoms (multi-trait analysis); CRC cis rs1150668 0.830 rs2531831 chr6:28388765 C/G cg06470822 chr6:28175283 NA 0.51 7.43 0.38 9.25e-13 Pubertal anthropometrics; CRC cis rs2976388 0.609 rs2376491 chr8:143790934 G/A cg04969067 chr8:143858791 LYNX1 0.44 7.53 0.38 5.09e-13 Urinary tract infection frequency; CRC cis rs10028773 0.700 rs7671797 chr4:120248157 A/G cg09307838 chr4:120376055 NA 0.62 9.67 0.47 1.25e-19 Educational attainment; CRC cis rs7843479 0.601 rs4872204 chr8:21841396 T/C cg17168535 chr8:21777572 XPO7 0.62 10.6 0.5 9.06e-23 Mean corpuscular volume; CRC cis rs62064224 0.614 rs4795700 chr17:30763794 A/G cg18200150 chr17:30822561 MYO1D 0.46 8.97 0.44 2.26e-17 Schizophrenia; CRC trans rs7937682 0.847 rs500163 chr11:111462649 T/G cg18187862 chr3:45730750 SACM1L 0.43 6.14 0.32 2.38e-9 Primary sclerosing cholangitis; CRC cis rs853679 0.517 rs12332979 chr6:28141548 T/G cg15845792 chr6:28175446 NA 1.04 13.81 0.61 1.6e-34 Depression; CRC trans rs2055729 0.736 rs11249965 chr8:9740863 C/G cg06636001 chr8:8085503 FLJ10661 -0.45 -6.45 -0.34 3.88e-10 Multiple myeloma (hyperdiploidy); CRC cis rs7412746 0.611 rs10788794 chr1:150728676 T/C cg15448220 chr1:150897856 SETDB1 0.52 7.3 0.37 2.16e-12 Melanoma; CRC cis rs4819052 1.000 rs4818769 chr21:46667451 C/T cg11663144 chr21:46675770 NA -0.8 -11.53 -0.54 4.47e-26 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs2976388 0.590 rs10110970 chr8:143820410 G/C cg04969067 chr8:143858791 LYNX1 -0.42 -6.66 -0.34 1.17e-10 Urinary tract infection frequency; CRC cis rs4713118 0.586 rs6905516 chr6:28086478 A/G cg12172441 chr6:28176163 NA 0.62 7.27 0.37 2.56e-12 Parkinson's disease; CRC cis rs1681630 1.000 rs1681630 chr11:47969152 A/G cg05585544 chr11:47624801 NA -0.42 -6.99 -0.36 1.58e-11 Height; CRC cis rs6582630 0.555 rs11182422 chr12:38522833 A/G cg26384229 chr12:38710491 ALG10B 0.69 9.91 0.48 1.95e-20 Drug-induced liver injury (flucloxacillin); CRC cis rs9814567 1.000 rs9851441 chr3:134315091 C/A cg06109529 chr3:134205091 CEP63;ANAPC13 -0.77 -11.26 -0.53 4.41e-25 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs965469 0.947 rs4611719 chr20:3228423 G/A cg25506879 chr20:3388711 C20orf194 -0.4 -5.7 -0.3 2.61e-8 IFN-related cytopenia; CRC cis rs11758351 1.000 rs74363821 chr6:26189524 G/C cg01420254 chr6:26195488 NA 0.83 8.87 0.44 4.86e-17 Gout;Renal underexcretion gout; CRC cis rs4072980 0.524 rs16824514 chr1:38395947 A/T cg12658694 chr1:38397304 INPP5B 0.47 6.76 0.35 6.29e-11 Coronary artery disease; CRC cis rs7737355 0.947 rs6864173 chr5:130871822 T/C cg06307176 chr5:131281290 NA 0.42 6.14 0.32 2.42e-9 Life satisfaction; CRC cis rs6761276 0.866 rs12469822 chr2:113830563 C/T cg09040174 chr2:113837401 NA 0.52 7.74 0.39 1.22e-13 Protein quantitative trait loci; CRC cis rs7215564 1.000 rs7215564 chr17:78737287 A/G cg09596252 chr17:78655493 RPTOR 0.56 5.97 0.31 6.07e-9 Myopia (pathological); CRC cis rs116095464 0.510 rs55750776 chr5:230467 T/C cg22496380 chr5:211416 CCDC127 -0.86 -10.04 -0.48 7.52e-21 Breast cancer; CRC cis rs12476592 0.602 rs6546018 chr2:63817422 G/T cg10828910 chr2:63850056 LOC388955 0.49 6.06 0.32 3.75e-9 Childhood ear infection; CRC cis rs807669 0.868 rs2800973 chr22:19168616 A/G cg02655711 chr22:19163373 SLC25A1 0.93 18.89 0.72 1.97e-54 Metabolite levels; CRC cis rs4555082 0.874 rs2816625 chr14:105734565 G/A cg13114125 chr14:105738426 BRF1 -0.8 -11.63 -0.54 2.08e-26 Mean platelet volume;Platelet distribution width; CRC cis rs478304 0.654 rs10896034 chr11:65460783 T/A cg05805236 chr11:65401703 PCNXL3 -0.42 -6.64 -0.34 1.29e-10 Acne (severe); CRC cis rs6500602 0.563 rs917305 chr16:4440593 C/T cg08645402 chr16:4508243 NA 0.49 6.49 0.34 3.2e-10 Schizophrenia; CRC cis rs4713118 0.662 rs9468274 chr6:28026077 G/T cg03623178 chr6:28175578 NA 0.92 13.02 0.58 1.52e-31 Parkinson's disease; CRC trans rs1005277 0.540 rs2224248 chr10:38451886 A/G cg11292332 chr7:45801988 SEPT13 -0.35 -6.22 -0.32 1.51e-9 Extrinsic epigenetic age acceleration; CRC cis rs7224685 0.501 rs4790168 chr17:4022457 T/C cg11204139 chr17:3907470 NA -0.75 -13.53 -0.6 1.83e-33 Type 2 diabetes; CRC cis rs755249 0.567 rs16826069 chr1:39797055 A/G cg18385671 chr1:39797026 MACF1 -0.4 -5.68 -0.3 2.98e-8 Peripheral arterial disease (traffic-related air pollution interaction); CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg01732804 chr2:220118692 TUBA4A;TUBA4B 0.44 6.06 0.32 3.79e-9 Anxiety disorder; CRC cis rs13256369 0.901 rs4841015 chr8:8567140 C/G cg06671706 chr8:8559999 CLDN23 0.54 7.76 0.39 1.09e-13 Obesity-related traits; CRC cis rs1552244 1.000 rs6782602 chr3:10116541 G/T cg02579736 chr3:10068473 FANCD2;CIDECP 0.97 13.13 0.59 6.13e-32 Alzheimer's disease; CRC cis rs796364 0.865 rs769948 chr2:200728475 C/A cg23649088 chr2:200775458 C2orf69 0.55 6.01 0.31 4.84e-9 Schizophrenia; CRC cis rs10221833 0.599 rs355834 chr2:165618056 G/A cg03182029 chr2:165697222 COBLL1 0.5 5.87 0.31 1.07e-8 Response to statin therapy; CRC cis rs10504229 0.683 rs62621195 chr8:58133964 G/A cg02290350 chr8:58132656 NA -0.58 -8.16 -0.41 7.29e-15 Developmental language disorder (linguistic errors); CRC cis rs826838 1.000 rs9795768 chr12:39012479 T/C cg26384229 chr12:38710491 ALG10B 0.73 10.16 0.49 2.96e-21 Heart rate; CRC cis rs798554 0.836 rs798490 chr7:2801542 C/T cg14863265 chr7:2801509 GNA12 -0.42 -5.78 -0.3 1.69e-8 Height; CRC cis rs73591976 0.539 rs12446198 chr16:68125972 G/A cg26727032 chr16:67993705 SLC12A4 -0.59 -6.68 -0.35 1.02e-10 HDL cholesterol; CRC cis rs68170813 0.559 rs12536491 chr7:106978024 T/G cg02696742 chr7:106810147 HBP1 -0.58 -6.28 -0.33 1.08e-9 Coronary artery disease; CRC cis rs1018836 0.923 rs10956748 chr8:91621537 T/A cg16814680 chr8:91681699 NA -0.75 -11.86 -0.55 3e-27 Ejection fraction in Tripanosoma cruzi seropositivity; CRC cis rs10540 0.558 rs12806062 chr11:501429 G/A cg21784768 chr11:537496 LRRC56 -0.66 -5.94 -0.31 7.19e-9 Body mass index; CRC trans rs208520 0.690 rs3899423 chr6:66835285 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.06 -14.61 -0.63 1.27e-37 Exhaled nitric oxide output; CRC cis rs1942 1.000 rs1942 chr15:41774423 A/G cg18705301 chr15:41695430 NDUFAF1 -0.44 -7.3 -0.37 2.15e-12 Eosinophil percentage of granulocytes; CRC cis rs7044106 0.791 rs10985008 chr9:123492960 G/A cg09586646 chr9:123605570 PSMD5;LOC253039 0.74 11.2 0.53 7.15e-25 Hip circumference adjusted for BMI; CRC cis rs4665809 0.590 rs4665840 chr2:26444962 C/T cg25036284 chr2:26402008 FAM59B -0.61 -7.76 -0.39 1.09e-13 Gut microbiome composition (summer); CRC cis rs10504229 0.639 rs2318145 chr8:58114867 A/G cg04204079 chr8:58130323 NA -0.45 -5.84 -0.31 1.27e-8 Developmental language disorder (linguistic errors); CRC trans rs3733585 0.673 rs6840802 chr4:9965633 C/G cg26043149 chr18:55253948 FECH 0.5 7.46 0.38 7.54e-13 Cleft plate (environmental tobacco smoke interaction); CRC cis rs10540 1.000 rs61876335 chr11:488878 T/C cg11503833 chr11:492997 NA 0.53 5.75 0.3 2.02e-8 Body mass index; CRC cis rs17376456 0.877 rs10476598 chr5:93367281 C/T cg09848695 chr5:92956644 FAM172A;MIR2277 -0.67 -6.73 -0.35 7.75e-11 Diabetic retinopathy; CRC trans rs1455244 0.700 rs7229302 chr18:11508904 G/T cg06363041 chr3:131100598 NUDT16 0.41 6.35 0.33 7.11e-10 Schizophrenia; CRC cis rs11148252 0.683 rs9536006 chr13:52887707 T/G cg02158880 chr13:53174818 NA 0.47 6.95 0.36 1.94e-11 Lewy body disease; CRC cis rs9649213 0.593 rs62478200 chr7:97980045 A/G cg21770322 chr7:97807741 LMTK2 0.53 8.73 0.43 1.33e-16 Prostate cancer (SNP x SNP interaction); CRC trans rs6693295 0.729 rs2185073 chr1:246213341 G/A cg03680032 chr11:94965610 SESN3 0.53 6.57 0.34 2e-10 Migraine - clinic-based;Migraine with aura; CRC cis rs2842992 0.830 rs2758312 chr6:160153452 G/A cg19482086 chr6:160211437 TCP1;MRPL18 0.73 9.48 0.46 5.06e-19 Age-related macular degeneration (geographic atrophy); CRC cis rs3892630 0.588 rs7248798 chr19:33303684 G/T cg22980127 chr19:33182716 NUDT19 0.91 12.55 0.57 8.93e-30 Red blood cell traits; CRC cis rs10256972 0.552 rs7805591 chr7:1210745 A/G cg23978390 chr7:1156363 C7orf50 0.52 7.21 0.37 3.97e-12 Longevity;Endometriosis; CRC cis rs7811142 0.667 rs3873746 chr7:99935097 G/A cg07160278 chr7:100027354 MEPCE;ZCWPW1 0.97 13.42 0.59 4.67e-33 Platelet count; CRC trans rs9956878 0.555 rs8085188 chr18:73544676 A/G cg03864326 chr16:67927170 PSKH1 -0.37 -6.02 -0.31 4.66e-9 Obesity-related traits; CRC cis rs11098499 0.644 rs3986377 chr4:120260270 G/A cg24375607 chr4:120327624 NA 0.47 7.68 0.39 1.83e-13 Corneal astigmatism; CRC cis rs11585357 0.895 rs2501795 chr1:17633499 A/G cg08277548 chr1:17600880 PADI3 -0.69 -9.17 -0.45 5.12e-18 Hair shape; CRC cis rs1448094 0.527 rs1900700 chr12:86232166 C/T cg25456477 chr12:86230367 RASSF9 0.37 6.38 0.33 5.95e-10 Major depressive disorder; CRC cis rs2033908 0.620 rs1440271 chr11:12852068 A/G cg25843174 chr11:12811716 TEAD1 -0.42 -7.56 -0.38 3.93e-13 Sitting height ratio; CRC trans rs6951245 1.000 rs11763793 chr7:1094342 A/G cg13565492 chr6:43139072 SRF -0.72 -7.46 -0.38 7.77e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC trans rs1979967 0.524 rs35014239 chr15:79658557 G/A cg14802097 chr12:42970349 PRICKLE1 0.52 6.06 0.32 3.64e-9 Interleukin-18 levels; CRC cis rs4713118 0.587 rs9393899 chr6:28133528 G/C cg02631126 chr6:28058918 ZSCAN12L1 0.29 5.91 0.31 8.38e-9 Parkinson's disease; CRC cis rs2836974 0.863 rs1065242 chr21:40567716 C/G cg06238570 chr21:40685208 BRWD1 0.78 10.7 0.51 3.88e-23 Cognitive function; CRC cis rs2730260 0.537 rs73169246 chr7:158890593 C/T cg02254261 chr7:158964346 NA -0.54 -6.19 -0.32 1.8e-9 Myopia (pathological); CRC cis rs752092 0.925 rs8032007 chr15:101790817 C/T cg19997662 chr15:101784653 CHSY1 0.57 9.31 0.46 1.91e-18 Corneal structure; CRC cis rs2576037 0.526 rs626217 chr18:44429182 T/G cg19077165 chr18:44547161 KATNAL2 -0.57 -9.51 -0.46 4.21e-19 Personality dimensions; CRC trans rs10982213 0.830 rs2274163 chr9:117188714 C/T cg01772115 chr1:90460555 ZNF326;LOC492303 0.41 6.39 0.33 5.57e-10 Interleukin-6 levels; CRC cis rs1707322 1.000 rs785510 chr1:46528618 T/C cg06784218 chr1:46089804 CCDC17 -0.6 -10.23 -0.49 1.64e-21 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs1570884 0.767 rs7996207 chr13:50122681 G/A cg08779649 chr13:50194554 NA 0.33 6.25 0.33 1.28e-9 Sum basophil neutrophil counts;Sum neutrophil eosinophil counts;Neutrophil count;Myeloid white cell count;Granulocyte count; CRC cis rs2032447 0.869 rs199752 chr6:26012875 C/T cg12310025 chr6:25882481 NA -0.57 -7.92 -0.4 3.74e-14 Intelligence (multi-trait analysis); CRC cis rs7959452 0.868 rs12812860 chr12:69746671 T/C cg14784868 chr12:69753453 YEATS4 0.67 10.39 0.5 4.82e-22 Blood protein levels; CRC cis rs1552244 0.935 rs66493421 chr3:10092569 G/A cg10729496 chr3:10149963 C3orf24 0.59 6.99 0.36 1.53e-11 Alzheimer's disease; CRC cis rs597539 0.652 rs622082 chr11:68703959 A/G cg04772025 chr11:68637568 NA 0.48 7.31 0.37 2.07e-12 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs11098499 0.863 rs11933966 chr4:120476715 G/A cg09307838 chr4:120376055 NA 0.67 10.02 0.48 8.25e-21 Corneal astigmatism; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg02273166 chr14:105487914 CDCA4 0.49 6.78 0.35 5.73e-11 Response to antipsychotic treatment; CRC cis rs3858526 0.920 rs10742832 chr11:5926020 C/G cg05234568 chr11:5960015 NA -0.53 -7.26 -0.37 2.82e-12 DNA methylation (variation); CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg02743050 chr15:57999273 GRINL1A;GCOM1 0.5 6.42 0.33 4.85e-10 Thyroid stimulating hormone; CRC cis rs12348691 0.503 rs907576 chr9:100615359 C/T cg13688889 chr9:100608707 NA -0.47 -6.05 -0.32 3.87e-9 Alopecia areata; CRC trans rs2303319 0.504 rs62189042 chr2:162602320 G/T cg22902534 chr3:183892754 AP2M1 -0.7 -6.1 -0.32 2.96e-9 Cognitive function; CRC trans rs6561151 0.681 rs7989702 chr13:44439150 T/C cg17145862 chr1:211918768 LPGAT1 0.49 6.4 0.33 5.47e-10 Crohn's disease; CRC cis rs17767392 0.509 rs72726677 chr14:71695208 T/A cg13720639 chr14:72061746 SIPA1L1 -0.51 -6.46 -0.34 3.84e-10 Mitral valve prolapse; CRC cis rs6570726 0.791 rs1280276 chr6:145892350 A/C cg05347473 chr6:146136440 FBXO30 0.41 6.2 0.32 1.69e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs924607 1.000 rs12523022 chr5:598643 C/T cg04221910 chr5:616842 CEP72 -0.42 -6.93 -0.36 2.28e-11 Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia; CRC cis rs2243480 0.803 rs160649 chr7:65543199 C/T cg12463550 chr7:65579703 CRCP 0.67 6.35 0.33 6.96e-10 Diabetic kidney disease; CRC cis rs755249 0.567 rs72661961 chr1:39831768 A/G cg18385671 chr1:39797026 MACF1 -0.4 -5.78 -0.3 1.74e-8 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs9916302 0.904 rs3744348 chr17:37417575 C/G cg07936489 chr17:37558343 FBXL20 -0.79 -12.04 -0.55 6.39e-28 Glomerular filtration rate (creatinine); CRC cis rs10512697 0.655 rs35093298 chr5:3460454 T/C cg19473799 chr5:3511975 NA -0.83 -6.34 -0.33 7.66e-10 Immune response to smallpox vaccine (IL-6); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg26671687 chr1:54872113 SSBP3 0.39 6.39 0.33 5.76e-10 Liver disease severity in Alagille syndrome; CRC cis rs4819052 0.565 rs35776291 chr21:46706142 T/C cg11663144 chr21:46675770 NA -0.67 -11.66 -0.54 1.59e-26 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs7771547 0.573 rs629721 chr6:36398229 T/C cg04289385 chr6:36355825 ETV7 0.38 5.61 0.3 4.25e-8 Platelet distribution width; CRC cis rs2991971 0.810 rs12738318 chr1:45929589 A/G cg15605315 chr1:45957053 TESK2 -0.4 -6.35 -0.33 7.22e-10 High light scatter reticulocyte count; CRC cis rs4664293 0.867 rs1834761 chr2:160601789 A/C cg08347373 chr2:160653686 CD302 -0.47 -7.43 -0.38 9.32e-13 Monocyte percentage of white cells; CRC cis rs4604732 0.631 rs7546720 chr1:247627229 G/A cg12754571 chr1:247694271 LOC148824;OR2C3 0.41 5.78 0.3 1.74e-8 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); CRC cis rs6502050 0.764 rs35416122 chr17:80119006 A/G cg22110888 chr17:80059540 CCDC57 0.4 6.38 0.33 5.96e-10 Life satisfaction; CRC cis rs6598955 0.671 rs10159433 chr1:26618370 A/G cg00852783 chr1:26633632 UBXN11 -0.49 -5.66 -0.3 3.34e-8 Obesity-related traits; CRC cis rs6693567 0.565 rs698921 chr1:150379517 G/A cg04165759 chr1:150448943 RPRD2 0.35 5.76 0.3 1.91e-8 Migraine; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg06227326 chr17:4269555 UBE2G1 0.46 6.37 0.33 6.25e-10 Response to antipsychotic treatment; CRC cis rs116095464 0.558 rs10462755 chr5:246748 T/C cg22496380 chr5:211416 CCDC127 -0.91 -10.37 -0.5 5.56e-22 Breast cancer; CRC trans rs1455244 0.700 rs7229302 chr18:11508904 G/T cg11700415 chr19:49140818 SEC1;DBP 0.44 6.97 0.36 1.72e-11 Schizophrenia; CRC cis rs4862750 0.914 rs1991256 chr4:187875330 A/G cg07414643 chr4:187882934 NA 0.37 6.48 0.34 3.29e-10 Lobe attachment (rater-scored or self-reported); CRC cis rs7264396 0.676 rs6058383 chr20:34556005 T/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.61 -9.9 -0.48 2.17e-20 Total cholesterol levels; CRC cis rs7264396 0.887 rs2236164 chr20:34097353 T/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.37 -6.13 -0.32 2.58e-9 Total cholesterol levels; CRC cis rs853679 0.769 rs7752448 chr6:28301099 A/G cg15845792 chr6:28175446 NA 0.84 7.96 0.4 2.84e-14 Depression; CRC cis rs12142240 0.698 rs55670684 chr1:46835139 C/T cg00530320 chr1:46809349 NSUN4 0.57 7.56 0.38 3.94e-13 Menopause (age at onset); CRC cis rs7103648 1.000 rs2293579 chr11:47440758 G/A cg20307385 chr11:47447363 PSMC3 0.98 17.96 0.7 9.57e-51 Diastolic blood pressure;Systolic blood pressure; CRC cis rs7095944 0.614 rs3824765 chr10:126433570 C/G cg08799069 chr10:126477246 METTL10 -0.44 -6.85 -0.35 3.69e-11 Asthma; CRC cis rs4713118 0.515 rs9368549 chr6:28050047 T/A cg06470822 chr6:28175283 NA 0.98 13.34 0.59 9.69e-33 Parkinson's disease; CRC cis rs4654899 0.802 rs17410008 chr1:21220701 G/C cg02927042 chr1:21476669 EIF4G3 -0.5 -7.83 -0.4 6.85e-14 Superior frontal gyrus grey matter volume; CRC cis rs1048238 0.506 rs848195 chr1:16286522 A/G cg21385522 chr1:16154831 NA -0.62 -9.12 -0.45 7.76e-18 Systolic blood pressure; CRC cis rs4819052 0.851 rs4819041 chr21:46659955 C/T cg19498844 chr21:46707878 POFUT2;LOC642852 0.64 9.33 0.46 1.6e-18 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg22800191 chr3:148847598 HPS3 0.42 5.96 0.31 6.35e-9 Response to antipsychotic treatment; CRC cis rs561341 0.882 rs2428337 chr17:30299467 C/T cg23018236 chr17:30244563 NA -0.66 -7.86 -0.4 5.69e-14 Hip circumference adjusted for BMI; CRC cis rs2952156 0.920 rs1476278 chr17:37836243 C/T cg20243544 chr17:37824526 PNMT 0.56 9.05 0.45 1.3e-17 Asthma; CRC cis rs4689592 0.513 rs2358718 chr4:7068743 A/C cg06697600 chr4:7070879 GRPEL1 0.52 7.55 0.38 4.37e-13 Monocyte percentage of white cells; CRC cis rs11229555 0.574 rs12272096 chr11:58186118 A/G cg15696309 chr11:58395628 NA -0.81 -10.31 -0.49 8.83e-22 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; CRC cis rs9640161 0.702 rs3735175 chr7:150020457 C/T cg12556325 chr7:150026731 C7orf29;LRRC61 -0.44 -6.49 -0.34 3.17e-10 Blood protein levels;Circulating chemerin levels; CRC cis rs2692947 0.526 rs58719199 chr2:96578247 G/A cg23100626 chr2:96804247 ASTL 0.27 7.11 0.36 7.33e-12 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; CRC cis rs9894429 1.000 rs7503679 chr17:79583843 G/C cg21028142 chr17:79581711 NPLOC4 0.39 8.62 0.43 2.89e-16 Eye color traits; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg02631680 chr6:44094852 TMEM63B;MRPL14 0.4 6.45 0.34 4.05e-10 Liver disease severity in Alagille syndrome; CRC cis rs713587 0.571 rs546217 chr2:25311537 A/C cg22495460 chr2:25135724 ADCY3 0.39 5.86 0.31 1.15e-8 Body mass index in non-asthmatics; CRC cis rs1800978 1.000 rs1800978 chr9:107665978 C/G cg14313833 chr9:107666037 ABCA1 -0.56 -5.77 -0.3 1.81e-8 Coronary artery disease; CRC cis rs4824093 0.610 rs2208023 chr22:50249983 A/G cg22709217 chr22:50311962 ALG12;CRELD2 -0.96 -8.4 -0.42 1.39e-15 Amyotrophic lateral sclerosis (sporadic); CRC cis rs1065656 0.563 rs391546 chr16:1915581 T/G cg14074117 chr16:1909714 C16orf73 -0.33 -5.83 -0.31 1.36e-8 Insulin-like growth factors; CRC cis rs6969780 1.000 rs73071548 chr7:27147430 A/G cg26364809 chr7:27145159 NA -0.73 -6.73 -0.35 7.69e-11 Diastolic blood pressure;Blood pressure traits (multi-trait analysis);Systolic blood pressure;Hypertension; CRC cis rs4332037 1.000 rs10240470 chr7:1949971 G/T cg02421172 chr7:1938701 MAD1L1 -0.43 -6.05 -0.32 3.84e-9 Bipolar disorder; CRC cis rs9435341 0.930 rs2232015 chr1:107599258 A/T cg14828511 chr1:107599125 PRMT6 0.57 8.0 0.4 2.11e-14 Facial morphology (factor 21, depth of nasal alae); CRC cis rs8031584 0.958 rs7176569 chr15:31244495 G/T cg08704250 chr15:31115839 NA 0.42 7.64 0.39 2.34e-13 Huntington's disease progression; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg19407570 chr11:61735476 FTH1 0.4 6.32 0.33 8.65e-10 Liver disease severity in Alagille syndrome; CRC cis rs11148252 0.532 rs9536262 chr13:53303074 A/C cg20354231 chr13:53171401 NA 0.42 6.95 0.36 1.92e-11 Lewy body disease; CRC trans rs10982213 0.830 rs2274163 chr9:117188714 C/T cg01867433 chr22:38966164 DMC1 0.39 6.27 0.33 1.13e-9 Interleukin-6 levels; CRC cis rs3806843 1.000 rs10073974 chr5:140165231 T/C cg19875535 chr5:140030758 IK 0.6 9.79 0.47 5.14e-20 Depressive symptoms (multi-trait analysis); CRC cis rs739401 0.611 rs391188 chr11:3047634 G/A cg08508325 chr11:3079039 CARS -0.52 -9.56 -0.47 2.84e-19 Longevity; CRC cis rs7927592 0.913 rs7115374 chr11:68300076 G/T cg16797656 chr11:68205561 LRP5 0.36 5.75 0.3 2.08e-8 Total body bone mineral density; CRC cis rs4803455 0.586 rs4803457 chr19:41861359 T/C cg08477640 chr19:41863820 B9D2 0.48 7.43 0.38 9.36e-13 Migraine;Coronary artery disease; CRC cis rs6456156 0.904 rs2023305 chr6:167524898 A/G cg05540913 chr6:167530185 CCR6 0.33 5.72 0.3 2.44e-8 Primary biliary cholangitis; CRC cis rs172166 0.538 rs1150686 chr6:28161271 T/G cg12273811 chr6:28175739 NA 0.45 6.81 0.35 4.63e-11 Cardiac Troponin-T levels; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg03341697 chr11:94277138 FUT4 0.44 6.05 0.32 3.88e-9 Response to antipsychotic treatment; CRC cis rs1838105 0.780 rs1623402 chr17:44994280 C/T cg16759221 chr17:45003025 GOSR2 -0.65 -10.49 -0.5 2.07e-22 Nonsyndromic cleft lip with cleft palate; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg25266327 chr19:16435660 KLF2 0.56 9.77 0.47 5.59e-20 Liver disease severity in Alagille syndrome; CRC trans rs11661542 0.967 rs11082043 chr18:20222985 C/G cg15543045 chr4:3487334 DOK7 -0.38 -5.97 -0.31 6.01e-9 Intracranial aneurysm; CRC cis rs1728785 1.000 rs1728781 chr16:68567794 A/T cg02972257 chr16:68554789 NA -0.58 -7.15 -0.37 5.78e-12 Ulcerative colitis; CRC cis rs9858542 0.953 rs3811697 chr3:49590770 C/T cg07274523 chr3:49395745 GPX1 0.47 6.41 0.33 5.12e-10 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs375066 0.623 rs1549955 chr19:44349861 T/C cg19542119 chr19:44331823 ZNF283 0.4 5.61 0.3 4.24e-8 Breast cancer; CRC cis rs11191205 0.686 rs10883676 chr10:103445325 A/C cg15320455 chr10:103880129 LDB1 -0.57 -6.48 -0.34 3.32e-10 Intelligence (multi-trait analysis); CRC cis rs8072100 0.713 rs8075058 chr17:45482857 A/G cg25173405 chr17:45401733 C17orf57 -0.43 -6.53 -0.34 2.49e-10 Very long-chain saturated fatty acid levels (fatty acid 20:0); CRC cis rs1570884 0.516 rs7330830 chr13:50167929 T/A cg08779649 chr13:50194554 NA 0.43 8.93 0.44 3.05e-17 Sum basophil neutrophil counts;Sum neutrophil eosinophil counts;Neutrophil count;Myeloid white cell count;Granulocyte count; CRC cis rs12819124 0.502 rs10875718 chr12:48411102 G/T cg21466736 chr12:48725269 NA -0.48 -7.48 -0.38 6.81e-13 Glycated hemoglobin levels; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg01172338 chr17:7297763 PLSCR3 0.45 6.9 0.36 2.73e-11 Liver disease severity in Alagille syndrome; CRC cis rs317689 0.819 rs317685 chr12:69715457 A/G cg14784868 chr12:69753453 YEATS4 -0.44 -5.62 -0.3 4.06e-8 Response to diuretic therapy; CRC trans rs10805346 0.505 rs35995899 chr4:10112862 T/C cg26043149 chr18:55253948 FECH 0.43 6.26 0.33 1.17e-9 Urate levels in overweight individuals;Urate levels in obese individuals; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg20918730 chr15:34629953 SLC12A6 0.44 6.09 0.32 3.23e-9 Anxiety disorder; CRC cis rs1552244 0.572 rs3774208 chr3:10164722 T/G cg00166722 chr3:10149974 C3orf24 0.65 7.7 0.39 1.56e-13 Alzheimer's disease; CRC cis rs8031584 0.541 rs2955797 chr15:31210981 A/G cg14829155 chr15:31115871 NA 0.35 5.68 0.3 2.93e-8 Huntington's disease progression; CRC cis rs490234 0.841 rs13285366 chr9:128375047 G/A cg14078157 chr9:128172775 NA -0.4 -6.72 -0.35 8.22e-11 Mean arterial pressure; CRC trans rs7618501 0.603 rs72942333 chr3:49986118 T/C cg21665057 chr3:196295764 WDR53;FBXO45 0.61 9.53 0.47 3.56e-19 Intelligence (multi-trait analysis); CRC cis rs7191439 0.858 rs7205626 chr16:88780472 T/C cg02389323 chr16:88786976 FAM38A 0.91 8.4 0.42 1.36e-15 Plateletcrit; CRC cis rs10256972 0.552 rs2960837 chr7:1203957 A/G cg03188948 chr7:1209495 NA 0.58 8.66 0.43 2.14e-16 Longevity;Endometriosis; CRC trans rs561341 1.000 rs7216102 chr17:30259450 A/G cg27661571 chr11:113659931 NA -0.61 -8.01 -0.4 1.97e-14 Hip circumference adjusted for BMI; CRC cis rs12887734 0.546 rs12886637 chr14:104222892 A/G cg08213375 chr14:104286397 PPP1R13B -0.53 -9.05 -0.45 1.28e-17 Schizophrenia;Autism spectrum disorder or schizophrenia; CRC cis rs12681287 0.640 rs6471309 chr8:87387760 C/T cg27223183 chr8:87520930 FAM82B -0.52 -7.05 -0.36 1.05e-11 Caudate activity during reward; CRC cis rs597539 0.652 rs622082 chr11:68703959 A/G cg06028808 chr11:68637592 NA 0.38 6.01 0.31 5.01e-9 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs41005 0.967 rs17433703 chr2:8115300 A/G cg03155496 chr2:8117019 LOC339788 0.4 6.98 0.36 1.6e-11 Response to anti-TNF therapy in rheumatoid arthritis; CRC trans rs6066835 0.867 rs11696900 chr20:47336967 C/A cg21109867 chr19:55897418 RPL28 -0.77 -6.37 -0.33 6.47e-10 Multiple myeloma; CRC trans rs11225569 0.540 rs10895423 chr11:103279762 A/C cg25722142 chr6:139695762 CITED2 -0.53 -6.62 -0.34 1.42e-10 Diisocyanate-induced asthma; CRC cis rs2067615 0.524 rs1922433 chr12:107077172 A/G cg13491945 chr12:107078410 RFX4 0.36 6.19 0.32 1.8e-9 Heart rate; CRC cis rs7659604 0.628 rs6838153 chr4:122720999 A/G cg06713675 chr4:122721982 EXOSC9 -0.52 -8.35 -0.42 1.95e-15 Type 2 diabetes; CRC cis rs3087591 0.960 rs4559963 chr17:29438558 G/A cg24425628 chr17:29625626 OMG;NF1 0.85 15.8 0.66 3.01e-42 Hip circumference; CRC cis rs7607369 0.714 rs4674332 chr2:219604326 C/T cg02176678 chr2:219576539 TTLL4 0.51 8.09 0.41 1.18e-14 Red blood cell count;Amyotrophic lateral sclerosis; CRC cis rs9942416 0.630 rs253388 chr5:74975912 A/G cg19683494 chr5:74908142 NA -0.49 -6.15 -0.32 2.26e-9 Age-related disease endophenotypes; CRC cis rs9858542 0.537 rs4410472 chr3:49329090 A/T cg00383909 chr3:49044727 WDR6 0.69 7.14 0.37 6.03e-12 Ulcerative colitis;Blood protein levels;Crohn's disease; CRC cis rs9291683 0.551 rs62295971 chr4:9978142 G/A cg11266682 chr4:10021025 SLC2A9 0.5 10.35 0.5 6.3e-22 Bone mineral density; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg13824859 chr6:109804376 ZBTB24 0.38 6.25 0.33 1.27e-9 Liver disease severity in Alagille syndrome; CRC cis rs9549367 0.737 rs71446680 chr13:113894846 C/T cg18105134 chr13:113819100 PROZ -0.72 -10.32 -0.49 8.19e-22 Platelet distribution width; CRC cis rs6908034 0.607 rs112824001 chr6:19804691 C/T cg02682789 chr6:19804855 NA 0.81 6.89 0.35 2.9100000000000002e-11 Endometriosis;Deep ovarian and/or rectovaginal disease with dense adhesions; CRC cis rs6121246 0.954 rs6060978 chr20:30416893 G/A cg18721089 chr20:30220636 NA -0.35 -5.7 -0.3 2.68e-8 Mean corpuscular hemoglobin; CRC cis rs9311474 0.629 rs7636227 chr3:52566682 G/A cg08222913 chr3:52553049 STAB1 -0.42 -8.56 -0.43 4.49e-16 Electroencephalogram traits; CRC cis rs9322193 0.651 rs9322188 chr6:149909491 A/G cg13206674 chr6:150067644 NUP43 -0.61 -9.0 -0.44 1.82e-17 Lung cancer; CRC trans rs11098499 0.909 rs1546502 chr4:120235898 A/G cg25214090 chr10:38739885 LOC399744 0.6 9.21 0.45 3.86e-18 Corneal astigmatism; CRC cis rs6545883 0.965 rs11887205 chr2:61774473 T/G cg15711740 chr2:61764176 XPO1 -0.52 -7.16 -0.37 5.41e-12 Tuberculosis; CRC cis rs2415984 0.579 rs2123129 chr14:46960920 G/T cg14871534 chr14:47121158 RPL10L -0.4 -6.08 -0.32 3.32e-9 Number of children ever born; CRC cis rs7107174 1.000 rs11237460 chr11:78056274 G/A cg02023728 chr11:77925099 USP35 0.47 8.31 0.42 2.53e-15 Testicular germ cell tumor; CRC cis rs6543140 0.964 rs4851589 chr2:103077145 A/G cg04239558 chr2:103089729 SLC9A4 0.34 6.08 0.32 3.3e-9 Blood protein levels; CRC cis rs8177179 0.503 rs9985395 chr3:133413119 A/G cg16262614 chr3:133464971 TF -0.32 -5.79 -0.3 1.64e-8 Iron status biomarkers (transferrin levels); CRC cis rs1448094 0.512 rs6539929 chr12:86244932 T/C cg18827107 chr12:86230957 RASSF9 -0.46 -7.53 -0.38 4.82e-13 Major depressive disorder; CRC cis rs7786808 0.741 rs11765319 chr7:158226790 A/G cg09998033 chr7:158218633 PTPRN2 -0.57 -8.19 -0.41 5.65e-15 Obesity-related traits; CRC cis rs9341808 0.622 rs682482 chr6:80961139 A/G cg08355045 chr6:80787529 NA -0.36 -6.01 -0.31 4.93e-9 Sitting height ratio; CRC cis rs873946 0.618 rs12775767 chr10:134545628 C/T cg26818010 chr10:134567672 INPP5A -0.66 -8.3 -0.42 2.75e-15 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); CRC cis rs597539 0.690 rs497149 chr11:68626639 A/T cg06028808 chr11:68637592 NA 0.43 6.84 0.35 3.78e-11 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs853679 0.550 rs1233699 chr6:28169158 A/T cg12172441 chr6:28176163 NA 0.69 9.14 0.45 6.56e-18 Depression; CRC cis rs7617773 0.539 rs6779517 chr3:48384388 C/T cg11946769 chr3:48343235 NME6 0.55 7.49 0.38 6.6e-13 Coronary artery disease; CRC cis rs875971 0.964 rs6945019 chr7:65922458 C/G cg12463550 chr7:65579703 CRCP 0.48 6.84 0.35 3.87e-11 Aortic root size; CRC cis rs17102884 0.506 rs887746 chr14:75403817 C/T cg03030879 chr14:75389066 RPS6KL1 0.37 5.72 0.3 2.45e-8 Neuroticism; CRC cis rs1552244 0.882 rs2130813 chr3:10038706 A/C cg13047869 chr3:10149882 C3orf24 0.53 7.15 0.37 5.67e-12 Alzheimer's disease; CRC trans rs1656966 1.000 rs1656966 chr3:186466252 C/T cg08905662 chr7:102789948 NAPEPLD 0.42 6.35 0.33 7.27e-10 Myopia (pathological); CRC cis rs13191362 0.507 rs2849540 chr6:163094522 G/A cg06582575 chr6:163149167 PACRG;PARK2 -0.56 -8.41 -0.42 1.3e-15 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs17401966 0.867 rs6696056 chr1:10305992 C/A cg19773385 chr1:10388646 KIF1B -0.64 -10.33 -0.49 7.45e-22 Hepatocellular carcinoma; CRC cis rs1499614 1.000 rs2707830 chr7:66167645 T/C cg25985355 chr7:65971099 NA -0.52 -5.92 -0.31 7.91e-9 Gout; CRC cis rs6860806 0.507 rs274572 chr5:131710917 T/G cg07395648 chr5:131743802 NA 0.43 6.01 0.31 5.01e-9 Breast cancer; CRC cis rs7945705 0.791 rs6484484 chr11:8817206 A/G cg21881798 chr11:8931708 C11orf17;ST5 0.52 8.36 0.42 1.75e-15 Hemoglobin concentration; CRC cis rs801193 0.569 rs6951302 chr7:66132512 T/C cg18252515 chr7:66147081 NA 0.44 6.2 0.32 1.72e-9 Aortic root size; CRC cis rs35306767 0.903 rs61833260 chr10:975148 T/G cg20503657 chr10:835505 NA 1.04 12.48 0.57 1.53e-29 Eosinophil percentage of granulocytes; CRC cis rs2243480 1.000 rs6966322 chr7:65646754 A/G cg12463550 chr7:65579703 CRCP -0.71 -6.52 -0.34 2.61e-10 Diabetic kidney disease; CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg27466237 chr4:184319924 NA 0.39 6.05 0.32 3.89e-9 Obesity-related traits; CRC trans rs61101201 0.962 rs10835790 chr11:31610022 C/T cg09380636 chr19:4791861 FEM1A -0.54 -6.48 -0.34 3.33e-10 Optic disc area; CRC cis rs7085104 0.572 rs284856 chr10:104574329 A/T cg04362960 chr10:104952993 NT5C2 -0.55 -8.16 -0.41 7.35e-15 Immature fraction of reticulocytes;Schizophrenia; CRC cis rs477895 0.713 rs12787852 chr11:63954648 G/A cg19465662 chr11:63993652 NUDT22;TRPT1 0.73 8.99 0.44 2.01e-17 Mean platelet volume; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg21864845 chr1:1208426 UBE2J2 0.45 5.97 0.31 6.23e-9 Thyroid stimulating hormone; CRC cis rs6502050 0.835 rs4789722 chr17:80151881 G/A cg19223190 chr17:80058835 NA 0.39 6.26 0.33 1.21e-9 Life satisfaction; CRC cis rs4563143 0.634 rs113736470 chr19:29240125 G/A cg03161606 chr19:29218774 NA 0.6 7.91 0.4 4.01e-14 Methadone dose in opioid dependence; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg17895626 chr17:1588142 PRPF8 0.43 5.98 0.31 5.95e-9 Anxiety disorder; CRC cis rs66731853 0.769 rs476582 chr1:20894450 A/G cg04087271 chr1:20915334 CDA -0.36 -5.89 -0.31 9.65e-9 Mean corpuscular volume; CRC cis rs7208859 0.673 rs9891179 chr17:29208160 G/T cg14008862 chr17:28927542 LRRC37B2 0.55 5.74 0.3 2.12e-8 Mean corpuscular hemoglobin;Mean corpuscular volume; CRC cis rs2180341 1.000 rs6937287 chr6:127645719 T/A cg24812749 chr6:127587940 RNF146 0.95 13.63 0.6 7.53e-34 Breast cancer; CRC cis rs938554 0.784 rs13145758 chr4:9981997 G/A cg00071950 chr4:10020882 SLC2A9 0.48 6.73 0.35 7.5e-11 Blood metabolite levels; CRC cis rs7927592 0.763 rs10791982 chr11:68337664 T/G cg01657329 chr11:68192670 LRP5 0.57 9.62 0.47 1.82e-19 Total body bone mineral density; CRC cis rs11252926 0.801 rs11252332 chr10:467318 A/T cg18196295 chr10:418757 DIP2C 0.59 8.39 0.42 1.42e-15 Psychosis in Alzheimer's disease; CRC cis rs12541335 0.639 rs35068739 chr8:22201719 T/C cg27266060 chr8:22091797 NA 0.35 5.77 0.3 1.81e-8 Hypertriglyceridemia; CRC cis rs3733346 0.553 rs6813110 chr4:942660 C/T cg08222618 chr4:941054 TMEM175 0.76 16.63 0.68 1.76e-45 Sjögren's syndrome; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg07577668 chr15:29432172 FAM189A1 0.4 6.33 0.33 8.23e-10 Intelligence (multi-trait analysis); CRC cis rs4713675 0.584 rs6916949 chr6:33678290 C/G cg14003231 chr6:33640908 ITPR3 0.49 7.85 0.4 5.97e-14 Plateletcrit; CRC cis rs854572 0.870 rs757158 chr7:94955528 C/T cg04155289 chr7:94953770 PON1 -0.78 -12.61 -0.57 5.16e-30 Paraoxonase activity; CRC cis rs807669 0.504 rs8141941 chr22:19166263 G/A cg02655711 chr22:19163373 SLC25A1 0.57 9.4 0.46 9.64e-19 Metabolite levels; CRC cis rs919433 0.680 rs1116734 chr2:198365043 C/G cg10820045 chr2:198174542 NA 0.41 6.89 0.36 2.88e-11 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC cis rs2404602 0.710 rs2469541 chr15:76562118 C/T cg26408565 chr15:76604113 ETFA 0.41 6.61 0.34 1.56e-10 Blood metabolite levels; CRC cis rs2836974 1.000 rs28360661 chr21:40681972 G/C cg07074390 chr21:40555500 PSMG1 -0.45 -6.01 -0.31 5.02e-9 Cognitive function; CRC cis rs9309473 0.607 rs6740173 chr2:73602266 C/G cg20560298 chr2:73613845 ALMS1 -0.5 -7.03 -0.36 1.2e-11 Metabolite levels; CRC cis rs1799949 1.000 rs34572725 chr17:41428666 G/A cg19454999 chr17:41278357 BRCA1;NBR2 0.52 8.15 0.41 7.66e-15 Menopause (age at onset); CRC cis rs10504229 0.683 rs2873638 chr8:58114593 G/A cg21724239 chr8:58056113 NA 0.49 6.77 0.35 5.94e-11 Developmental language disorder (linguistic errors); CRC cis rs9291683 0.632 rs13101785 chr4:10042915 T/A cg00071950 chr4:10020882 SLC2A9 0.67 12.67 0.57 3.14e-30 Bone mineral density; CRC cis rs4713118 0.516 rs7739216 chr6:28079946 G/T cg21251018 chr6:28226885 NKAPL 0.48 6.22 0.32 1.48e-9 Parkinson's disease; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg01994328 chr10:30723347 MAP3K8 0.41 6.37 0.33 6.2e-10 Intelligence (multi-trait analysis); CRC trans rs2303319 0.504 rs60495163 chr2:162408807 C/T cg18122310 chr12:50236657 BCDIN3D -0.72 -6.07 -0.32 3.58e-9 Cognitive function; CRC cis rs1448094 0.967 rs10863109 chr12:86328415 A/G cg18827107 chr12:86230957 RASSF9 -0.37 -6.1 -0.32 2.98e-9 Major depressive disorder; CRC cis rs11958404 0.789 rs78112793 chr5:157428226 A/G cg05962755 chr5:157440814 NA 0.87 11.03 0.52 2.87e-24 IgG glycosylation; CRC cis rs9462846 0.853 rs7757363 chr6:42876386 C/T cg21280719 chr6:42927975 GNMT -0.31 -5.84 -0.31 1.23e-8 Blood protein levels; CRC cis rs55675132 0.510 rs72691963 chr1:115297986 T/C cg12756093 chr1:115239321 AMPD1 0.52 6.24 0.33 1.34e-9 Schizophrenia; CRC cis rs6840360 0.573 rs6810430 chr4:152259759 C/T cg09659197 chr4:152720779 NA 0.31 6.05 0.32 3.97e-9 Intelligence (multi-trait analysis); CRC cis rs11758351 0.660 rs77337633 chr6:26233610 T/C cg22723502 chr6:26240528 HIST1H4F -0.36 -5.92 -0.31 8.02e-9 Gout;Renal underexcretion gout; CRC cis rs7772486 0.790 rs7742333 chr6:146159029 A/G cg13319975 chr6:146136371 FBXO30 0.43 6.3 0.33 9.6e-10 Lobe attachment (rater-scored or self-reported); CRC cis rs8180040 0.701 rs7625067 chr3:47095305 T/C cg02527881 chr3:46936655 PTH1R -0.4 -7.53 -0.38 4.79e-13 Colorectal cancer; CRC trans rs2303319 0.504 rs62189055 chr2:162625749 C/A cg03757145 chr4:76555832 CDKL2 -0.65 -6.0 -0.31 5.07e-9 Cognitive function; CRC cis rs977987 0.806 rs8054769 chr16:75401113 T/C cg03315344 chr16:75512273 CHST6 0.54 9.11 0.45 8.15e-18 Dupuytren's disease; CRC cis rs919433 1.000 rs1346649 chr2:198166117 C/A cg20885578 chr2:198174922 NA -0.38 -6.73 -0.35 7.61e-11 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC cis rs6582630 0.555 rs10748382 chr12:38504529 C/T cg26384229 chr12:38710491 ALG10B 0.71 9.98 0.48 1.15e-20 Drug-induced liver injury (flucloxacillin); CRC cis rs1862618 0.671 rs2591957 chr5:56243146 A/T cg18230493 chr5:56204884 C5orf35 0.6 8.91 0.44 3.62e-17 Initial pursuit acceleration; CRC cis rs910316 1.000 rs910316 chr14:75626042 A/C cg03030879 chr14:75389066 RPS6KL1 -0.47 -7.22 -0.37 3.69e-12 Height; CRC cis rs72634258 0.945 rs2050198 chr1:8111839 T/G cg26816564 chr1:7831052 VAMP3 0.55 6.05 0.32 3.92e-9 Inflammatory bowel disease; CRC cis rs1005277 0.579 rs2474572 chr10:38385316 A/G cg17219203 chr10:38645113 HSD17B7P2 -0.41 -5.96 -0.31 6.54e-9 Extrinsic epigenetic age acceleration; CRC cis rs78545713 0.536 rs56119218 chr6:26225881 C/A cg01420254 chr6:26195488 NA 0.66 5.87 0.31 1.04e-8 Iron status biomarkers (total iron binding capacity); CRC cis rs9916302 0.731 rs11868030 chr17:37650332 A/G cg07936489 chr17:37558343 FBXL20 -0.84 -13.29 -0.59 1.51e-32 Glomerular filtration rate (creatinine); CRC cis rs12900463 0.813 rs186266 chr15:85402795 A/G cg17507749 chr15:85114479 UBE2QP1 0.43 5.77 0.3 1.87e-8 Adverse response to chemotherapy (neutropenia/leucopenia) (gemcitabine); CRC cis rs9399137 0.507 rs7761964 chr6:135314265 T/C cg24558204 chr6:135376177 HBS1L 0.62 9.46 0.46 5.88e-19 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg12108527 chr1:43233151 LEPRE1;C1orf50 0.5 6.39 0.33 5.81e-10 Thyroid stimulating hormone; CRC cis rs6964587 0.610 rs7788951 chr7:91468765 A/T cg17063962 chr7:91808500 NA 0.57 8.89 0.44 4.02e-17 Breast cancer; CRC cis rs4713118 0.868 rs10484401 chr6:27746590 A/T cg15786705 chr6:28176104 NA -0.57 -6.33 -0.33 7.86e-10 Parkinson's disease; CRC cis rs6429082 0.818 rs834198 chr1:235671987 A/G cg26050004 chr1:235667680 B3GALNT2 0.58 7.78 0.39 9.32e-14 Adiposity; CRC cis rs11148252 0.508 rs11148260 chr13:53162643 A/C cg12458913 chr13:53173898 NA 0.8 15.02 0.64 3.28e-39 Lewy body disease; CRC cis rs9443189 0.570 rs504446 chr6:76326939 T/C cg01950844 chr6:76311363 SENP6 0.75 10.01 0.48 9.2e-21 Prostate cancer; CRC cis rs4665809 0.590 rs7579504 chr2:26439995 T/C cg08067268 chr2:26466485 HADHB;HADHA -0.65 -8.34 -0.42 2e-15 Gut microbiome composition (summer); CRC trans rs2727020 0.731 rs10450572 chr11:49281073 T/C cg15704280 chr7:45808275 SEPT13 0.87 15.26 0.64 3.78e-40 Coronary artery disease; CRC cis rs2976388 0.967 rs2976393 chr8:143763618 C/G cg04969067 chr8:143858791 LYNX1 -0.34 -5.81 -0.31 1.45e-8 Urinary tract infection frequency; CRC cis rs10242455 0.571 rs56167514 chr7:99161347 A/G cg18809830 chr7:99032528 PTCD1 -1.08 -8.01 -0.4 2.03e-14 Blood metabolite levels; CRC cis rs12701220 0.503 rs12702047 chr7:1132720 G/A cg26769984 chr7:1090371 C7orf50 0.49 5.95 0.31 6.98e-9 Bronchopulmonary dysplasia; CRC cis rs3617 0.625 rs2239548 chr3:52854186 A/C cg11645453 chr3:52864694 ITIH4 0.46 9.08 0.45 1.01e-17 Red blood cell count;Autism spectrum disorder or schizophrenia; CRC cis rs9462027 0.561 rs2262245 chr6:34567694 T/C cg07306190 chr6:34760872 UHRF1BP1 -0.35 -6.01 -0.31 4.79e-9 Systemic lupus erythematosus; CRC cis rs6460942 1.000 rs111761262 chr7:12415916 T/C cg20607287 chr7:12443886 VWDE -0.62 -6.58 -0.34 1.84e-10 Coronary artery disease; CRC cis rs9398803 0.835 rs59698523 chr6:126733094 T/C cg19875578 chr6:126661172 C6orf173 0.4 5.74 0.3 2.12e-8 Male-pattern baldness; CRC cis rs12200560 0.505 rs211167 chr6:97069087 T/A cg06623918 chr6:96969491 KIAA0776 0.47 6.76 0.35 6.35e-11 Coronary heart disease; CRC cis rs10504229 0.683 rs17194792 chr8:58107195 A/C cg22535103 chr8:58192502 C8orf71 -0.8 -8.56 -0.43 4.32e-16 Developmental language disorder (linguistic errors); CRC trans rs9467711 0.606 rs9366656 chr6:26434630 T/C cg06606381 chr12:133084897 FBRSL1 -0.85 -6.39 -0.33 5.62e-10 Autism spectrum disorder or schizophrenia; CRC trans rs2994684 0.736 rs11008385 chr10:31453788 A/C cg04844971 chr15:50979486 TRPM7 0.42 6.15 0.32 2.24e-9 Response to antipsychotic treatment; CRC cis rs4819052 0.851 rs1999335 chr21:46670613 A/G cg19498844 chr21:46707878 POFUT2;LOC642852 0.75 10.72 0.51 3.39e-23 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC trans rs11098499 0.779 rs10016060 chr4:120298412 A/G cg25214090 chr10:38739885 LOC399744 0.62 9.74 0.47 7.35e-20 Corneal astigmatism; CRC cis rs12024301 0.557 rs56758429 chr1:183637537 A/C cg11505048 chr1:183622726 RGL1;APOBEC4 0.81 7.0 0.36 1.42e-11 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs9914988 0.887 rs9895625 chr17:27108516 A/G cg20469991 chr17:27169893 C17orf63 -0.6 -7.27 -0.37 2.59e-12 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; CRC cis rs1712517 0.740 rs4293062 chr10:105052624 G/A cg05636881 chr10:105038444 INA 0.47 8.08 0.41 1.23e-14 Migraine; CRC cis rs8177253 0.763 rs12769 chr3:133474328 G/A cg08048268 chr3:133502702 NA -0.33 -5.85 -0.31 1.19e-8 Iron status biomarkers; CRC cis rs6499255 0.951 rs10163235 chr16:69739867 G/T cg04110750 chr16:69646130 NFAT5 -0.56 -7.78 -0.39 9.55e-14 IgE levels; CRC cis rs801193 0.569 rs6978178 chr7:66123084 G/A cg18876405 chr7:65276391 NA -0.5 -8.03 -0.4 1.79e-14 Aortic root size; CRC cis rs72781680 1.000 rs72796389 chr2:24171761 A/G cg08917208 chr2:24149416 ATAD2B 0.91 9.24 0.45 3.06e-18 Lymphocyte counts; CRC trans rs6545883 0.965 rs766447 chr2:61735569 C/T cg11704114 chr12:21509398 SLCO1A2 -0.33 -6.22 -0.32 1.52e-9 Tuberculosis; CRC trans rs11722228 0.508 rs61335146 chr4:10130793 G/C cg26043149 chr18:55253948 FECH 1.02 17.35 0.69 2.36e-48 Gout;Urate levels;Serum uric acid levels; CRC trans rs2727020 0.576 rs11040223 chr11:49034633 G/T cg00717180 chr2:96193071 NA -0.42 -6.91 -0.36 2.46e-11 Coronary artery disease; CRC trans rs6951245 0.938 rs117729148 chr7:1108531 G/A cg13565492 chr6:43139072 SRF -0.72 -7.5 -0.38 6.06e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs1200821 0.529 rs4934856 chr10:37807847 T/C cg25427524 chr10:38739819 LOC399744 0.6 9.64 0.47 1.6e-19 Hemostatic factors and hematological phenotypes; CRC cis rs9807989 0.507 rs10204757 chr2:102998974 A/C cg03938978 chr2:103052716 IL18RAP 0.59 10.12 0.49 3.77e-21 Asthma; CRC cis rs10504229 0.683 rs55645894 chr8:58116145 A/G cg02290350 chr8:58132656 NA -0.58 -8.16 -0.41 7.29e-15 Developmental language disorder (linguistic errors); CRC cis rs11122272 0.735 rs2250704 chr1:231486647 A/G cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.51 -7.65 -0.39 2.26e-13 Hemoglobin concentration; CRC cis rs4713118 0.662 rs149970 chr6:27980220 C/T cg25164649 chr6:28176230 NA 0.67 9.1 0.45 8.98e-18 Parkinson's disease; CRC cis rs77972916 0.505 rs6727824 chr2:43528377 A/G cg06169590 chr2:43455088 ZFP36L2;LOC100129726 -0.65 -7.69 -0.39 1.71e-13 Granulocyte percentage of myeloid white cells; CRC cis rs2153535 0.563 rs1737585 chr6:8536594 A/G cg07606381 chr6:8435919 SLC35B3 -0.67 -10.87 -0.51 1.03e-23 Motion sickness; CRC cis rs117623576 0.941 rs72784857 chr10:32441029 C/T cg03047570 chr10:32398778 NA -0.68 -6.56 -0.34 2.09e-10 Anti-saccade response; CRC cis rs10504073 0.647 rs4873314 chr8:50011656 A/C cg00325661 chr8:49890786 NA 0.52 9.4 0.46 9.66e-19 Blood metabolite ratios; CRC trans rs11105468 1.000 rs7975788 chr12:90273927 T/G cg23572944 chr11:60720130 SLC15A3 -0.44 -6.08 -0.32 3.26e-9 Febrile seizures;Febrile seizures (MMR vaccine-related);Febrile seizures (MMR vaccine-unrelated); CRC cis rs4400599 0.618 rs1194580 chr1:154219485 G/T cg26808167 chr1:154192205 UBAP2L;C1orf43 -0.36 -5.71 -0.3 2.49e-8 Platelet distribution width; CRC cis rs2120019 1.000 rs12898259 chr15:75369780 G/A cg17294928 chr15:75287854 SCAMP5 -0.73 -10.92 -0.52 6.61e-24 Blood trace element (Zn levels); CRC cis rs2153535 0.580 rs6941771 chr6:8494452 T/G cg07606381 chr6:8435919 SLC35B3 0.67 10.71 0.51 3.6e-23 Motion sickness; CRC cis rs1552172 0.887 rs2318299 chr1:145662666 C/T cg11743829 chr1:145714124 CD160 0.41 6.16 0.32 2.15e-9 Breast cancer; CRC cis rs6952808 0.609 rs10227517 chr7:1950292 A/T cg22963979 chr7:1858916 MAD1L1 -0.42 -6.68 -0.35 1.01e-10 Bipolar disorder and schizophrenia; CRC cis rs7647973 0.626 rs7637711 chr3:49829653 A/G cg03060546 chr3:49711283 APEH -0.66 -8.06 -0.41 1.42e-14 Menarche (age at onset); CRC cis rs6123683 0.738 rs6025465 chr20:55824147 A/G cg13236649 chr20:55835020 BMP7 0.49 7.51 0.38 5.63e-13 Facial morphology (factor 5, width of mouth relative to central midface); CRC cis rs597539 0.654 rs655816 chr11:68626405 A/G cg04772025 chr11:68637568 NA 0.54 8.51 0.42 6.04e-16 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; CRC cis rs9814567 1.000 rs7637227 chr3:134244155 G/A cg06541857 chr3:134203789 ANAPC13;CEP63 -0.39 -5.82 -0.31 1.4e-8 Neurocognitive impairment in HIV-1 infection (dichotomous); CRC cis rs798554 0.704 rs798531 chr7:2770067 G/C cg04166393 chr7:2884313 GNA12 0.4 6.09 0.32 3.18e-9 Height; CRC cis rs3806843 0.548 rs246058 chr5:140325134 G/A cg19875535 chr5:140030758 IK 0.39 6.02 0.31 4.67e-9 Depressive symptoms (multi-trait analysis); CRC trans rs11039798 0.925 rs7929225 chr11:48931739 G/C cg03929089 chr4:120376271 NA 0.64 6.1 0.32 2.95e-9 Axial length; CRC cis rs1799949 0.602 rs4600503 chr17:41414324 C/G cg01879757 chr17:41196368 BRCA1 -0.44 -6.68 -0.35 1.04e-10 Menopause (age at onset); CRC cis rs853679 0.506 rs1150711 chr6:28208535 T/C cg21251018 chr6:28226885 NKAPL 0.54 8.56 0.43 4.32e-16 Depression; CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg00040446 chr1:40367965 MYCL1 0.42 6.76 0.35 6.42e-11 Obesity-related traits; CRC cis rs875971 0.862 rs13232191 chr7:65986648 A/G cg18876405 chr7:65276391 NA 0.52 8.38 0.42 1.6e-15 Aortic root size; CRC cis rs72781680 1.000 rs6731001 chr2:24192952 A/G cg08917208 chr2:24149416 ATAD2B 0.91 9.28 0.46 2.29e-18 Lymphocyte counts; CRC cis rs1862618 0.641 rs2591954 chr5:56245044 G/C cg03609598 chr5:56110824 MAP3K1 0.59 7.99 0.4 2.34e-14 Initial pursuit acceleration; CRC cis rs2073300 0.609 rs6137919 chr20:23363163 T/C cg12062639 chr20:23401060 NAPB 0.71 6.48 0.34 3.37e-10 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs6088590 0.648 rs6059991 chr20:33280836 C/T cg24642439 chr20:33292090 TP53INP2 0.46 8.05 0.41 1.48e-14 Coronary artery disease; CRC cis rs713587 1.000 rs713587 chr2:25158281 C/T cg04586622 chr2:25135609 ADCY3 -0.43 -7.56 -0.38 3.96e-13 Body mass index in non-asthmatics; CRC cis rs1707322 0.964 rs1768802 chr1:46547868 A/G cg03146154 chr1:46216737 IPP -0.52 -7.18 -0.37 4.54e-12 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs28386778 0.897 rs2727327 chr17:61923422 G/A cg22520471 chr17:61851767 DDX42;CCDC47 0.75 11.6 0.54 2.64e-26 Prudent dietary pattern; CRC cis rs8010715 0.816 rs2332224 chr14:24598544 C/G cg23112188 chr14:24563095 PCK2 -0.36 -6.97 -0.36 1.73e-11 IgG glycosylation; CRC cis rs898097 0.690 rs12452304 chr17:80811659 G/A cg15664640 chr17:80829946 TBCD -0.69 -11.7 -0.54 1.14e-26 Breast cancer; CRC cis rs3096299 0.632 rs4399533 chr16:89539382 G/C cg00750074 chr16:89608354 SPG7 -0.48 -7.33 -0.37 1.84e-12 Multiple myeloma (IgH translocation); CRC cis rs1799949 1.000 rs1824889 chr17:41421876 C/G cg05368731 chr17:41323189 NBR1 0.67 10.14 0.49 3.45e-21 Menopause (age at onset); CRC cis rs950776 0.518 rs1504545 chr15:78818471 C/G cg22563815 chr15:78856949 CHRNA5 -0.31 -5.67 -0.3 3.21e-8 Sudden cardiac arrest; CRC cis rs4731207 0.698 rs6415362 chr7:124530650 T/C cg23710748 chr7:124431027 NA -0.38 -6.09 -0.32 3.13e-9 Cutaneous malignant melanoma; CRC cis rs7605827 0.930 rs6708288 chr2:15535477 A/G cg19274914 chr2:15703543 NA 0.39 5.88 0.31 9.87e-9 Educational attainment (years of education); CRC cis rs6951245 1.000 rs11763793 chr7:1094342 A/G cg04025307 chr7:1156635 C7orf50 0.63 6.75 0.35 6.62e-11 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs728616 0.764 rs56122289 chr10:81746027 G/A cg05935833 chr10:81318306 SFTPA2 -0.74 -8.01 -0.4 1.94e-14 Chronic obstructive pulmonary disease-related biomarkers; CRC cis rs4727027 0.933 rs7788925 chr7:148831621 A/G cg12479418 chr7:148823350 ZNF425;ZNF398 0.42 5.75 0.3 2.05e-8 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; CRC cis rs2857891 0.817 rs2239733 chr11:6976666 T/C cg04053776 chr11:6947353 ZNF215 0.39 5.69 0.3 2.78e-8 Response to cytadine analogues (cytosine arabinoside); CRC cis rs9039 1.000 rs11075212 chr16:9203899 G/A cg08831531 chr16:9218945 NA -0.57 -6.8 -0.35 4.8e-11 Menopause (age at onset); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg01026373 chr5:141071769 NA 0.42 6.41 0.33 4.99e-10 Liver disease severity in Alagille syndrome; CRC cis rs9322193 0.923 rs10747275 chr6:149943918 C/T cg00933542 chr6:150070202 PCMT1 0.31 6.38 0.33 5.85e-10 Lung cancer; CRC cis rs11958404 0.860 rs7723564 chr5:157449396 C/T cg05962755 chr5:157440814 NA 1.0 12.81 0.58 9.7e-31 IgG glycosylation; CRC cis rs10504073 0.647 rs28685207 chr8:50003484 A/G cg00325661 chr8:49890786 NA 0.42 7.64 0.39 2.35e-13 Blood metabolite ratios; CRC cis rs12497850 0.543 rs6446218 chr3:49075513 A/T cg07636037 chr3:49044803 WDR6 1.04 18.15 0.71 1.62e-51 Parkinson's disease; CRC cis rs11098499 0.691 rs9996494 chr4:120238880 C/A cg09307838 chr4:120376055 NA 0.63 9.79 0.47 5.05e-20 Corneal astigmatism; CRC cis rs637571 0.522 rs503524 chr11:65751764 C/T cg26695010 chr11:65641043 EFEMP2 -0.4 -6.09 -0.32 3.17e-9 Eosinophil percentage of white cells; CRC trans rs1814175 0.527 rs7110797 chr11:49644096 T/C cg15704280 chr7:45808275 SEPT13 -0.75 -10.04 -0.48 7.09e-21 Height; CRC cis rs2404602 0.716 rs1125932 chr15:76820540 C/T cg22467129 chr15:76604101 ETFA -0.4 -6.52 -0.34 2.64e-10 Blood metabolite levels; CRC cis rs4409675 0.576 rs6598912 chr1:28233289 C/T cg23691781 chr1:28212827 C1orf38 0.32 7.51 0.38 5.73e-13 Corneal astigmatism; CRC cis rs7772486 0.597 rs1970306 chr6:146154543 A/G cg05347473 chr6:146136440 FBXO30 0.5 7.2 0.37 4.16e-12 Lobe attachment (rater-scored or self-reported); CRC cis rs1538970 0.924 rs4660858 chr1:45936351 G/A cg05343316 chr1:45956843 TESK2 0.73 9.83 0.48 3.72e-20 Platelet count; CRC trans rs1814175 0.616 rs1794139 chr11:49910855 C/T cg03929089 chr4:120376271 NA -0.91 -15.56 -0.65 2.66e-41 Height; CRC cis rs1799949 1.000 rs8070085 chr17:41341984 C/T cg25072359 chr17:41440525 NA -0.41 -6.21 -0.32 1.59e-9 Menopause (age at onset); CRC cis rs116095464 0.510 rs7723883 chr5:270798 T/C cg22496380 chr5:211416 CCDC127 -0.85 -9.99 -0.48 1.06e-20 Breast cancer; CRC cis rs2336384 1.000 rs4846085 chr1:12050634 T/C cg13216073 chr1:12042593 MFN2 0.48 7.06 0.36 1.03e-11 Platelet count; CRC cis rs72945132 0.882 rs17160039 chr11:70145489 A/G cg00319359 chr11:70116639 PPFIA1 0.68 7.51 0.38 5.61e-13 Coronary artery disease; CRC cis rs7666738 0.830 rs10021044 chr4:99002488 A/T cg17366294 chr4:99064904 C4orf37 0.44 7.39 0.38 1.19e-12 Colonoscopy-negative controls vs population controls; CRC cis rs10504229 1.000 rs56740825 chr8:58175617 A/G cg02290350 chr8:58132656 NA -0.42 -5.96 -0.31 6.62e-9 Developmental language disorder (linguistic errors); CRC cis rs10751667 0.666 rs7950967 chr11:955638 G/A ch.11.42038R chr11:967971 AP2A2 0.57 9.75 0.47 6.98e-20 Alzheimer's disease (late onset); CRC cis rs7811142 0.887 rs4074838 chr7:100032665 G/A cg00814883 chr7:100076585 TSC22D4 -0.75 -9.53 -0.47 3.63e-19 Platelet count; CRC cis rs9311474 0.508 rs17052256 chr3:52593119 A/G cg10802521 chr3:52805072 NEK4 -0.56 -8.91 -0.44 3.55e-17 Electroencephalogram traits; CRC cis rs763014 0.932 rs2384974 chr16:651279 C/G cg07343612 chr16:622815 PIGQ -0.82 -14.28 -0.62 2.44e-36 Height; CRC cis rs55871839 0.708 rs4738730 chr8:59808935 A/T cg07426533 chr8:59803705 TOX -0.34 -5.93 -0.31 7.82e-9 Pneumonia; CRC cis rs4862750 0.872 rs6811569 chr4:187897988 A/G cg03647317 chr4:187891568 NA 0.55 10.09 0.49 4.85e-21 Lobe attachment (rater-scored or self-reported); CRC cis rs644799 1.000 rs509720 chr11:95562771 T/C cg03916912 chr11:95522834 CEP57;FAM76B 0.95 18.38 0.71 2.03e-52 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); CRC cis rs6570726 1.000 rs436066 chr6:145847127 C/T cg23711669 chr6:146136114 FBXO30 0.68 12.13 0.56 3.13e-28 Lobe attachment (rater-scored or self-reported); CRC cis rs6545883 0.524 rs2463101 chr2:61574422 G/C cg10580144 chr2:61372316 C2orf74 -0.35 -7.78 -0.39 9.7e-14 Tuberculosis; CRC cis rs2228479 0.850 rs62054611 chr16:89817017 T/C cg06656553 chr16:89960601 TCF25 -0.69 -5.74 -0.3 2.15e-8 Skin colour saturation; CRC cis rs7659604 1.000 rs28618203 chr4:122663935 T/C cg06713675 chr4:122721982 EXOSC9 -0.37 -6.01 -0.31 4.96e-9 Type 2 diabetes; CRC cis rs9611565 0.512 rs7291736 chr22:42124874 C/A cg06634786 chr22:41940651 POLR3H 0.64 7.32 0.37 1.94e-12 Vitiligo; CRC cis rs2228479 0.850 rs1800331 chr16:89858417 C/A cg19635926 chr16:89946313 TCF25 0.68 6.39 0.33 5.65e-10 Skin colour saturation; CRC cis rs6503525 0.628 rs4065985 chr17:38101932 G/C cg24910161 chr17:38119198 GSDMA -0.43 -7.65 -0.39 2.24e-13 Asthma; CRC cis rs1059312 1.000 rs3825180 chr12:129279242 A/G cg21616243 chr12:129299702 MGC16384;SLC15A4 0.64 10.63 0.51 7.18e-23 Systemic lupus erythematosus; CRC cis rs17539620 0.519 rs871071 chr6:154837667 T/C cg20019720 chr6:154832845 CNKSR3 0.54 10.66 0.51 5.66e-23 Lipoprotein (a) levels; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg15114836 chr19:925199 ARID3A 0.43 6.03 0.32 4.46e-9 Intelligence (multi-trait analysis); CRC cis rs910316 0.967 rs4903293 chr14:75656568 A/G cg08847533 chr14:75593920 NEK9 -0.84 -14.46 -0.62 4.91e-37 Height; CRC trans rs4824093 0.535 rs73441802 chr22:50273916 G/A cg09872104 chr7:134855509 C7orf49 -0.81 -7.1 -0.36 7.61e-12 Amyotrophic lateral sclerosis (sporadic); CRC cis rs45509595 0.841 rs200485 chr6:27775697 G/C cg08798685 chr6:27730294 NA -0.62 -5.95 -0.31 7.04e-9 Breast cancer; CRC cis rs7772486 0.790 rs4314514 chr6:146260010 A/G cg13319975 chr6:146136371 FBXO30 0.41 6.24 0.33 1.32e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs7618501 0.633 rs2008877 chr3:50162291 T/G cg24308560 chr3:49941425 MST1R 0.46 7.11 0.36 7.33e-12 Intelligence (multi-trait analysis); CRC cis rs1552244 0.882 rs17050672 chr3:10025463 G/A cg10729496 chr3:10149963 C3orf24 0.52 6.33 0.33 8.22e-10 Alzheimer's disease; CRC cis rs9733 0.596 rs17658705 chr1:150678071 A/C cg17724175 chr1:150552817 MCL1 -0.58 -9.21 -0.45 3.86e-18 Tonsillectomy; CRC cis rs7927592 0.913 rs7106339 chr11:68240241 C/T cg01657329 chr11:68192670 LRP5 -0.46 -6.54 -0.34 2.39e-10 Total body bone mineral density; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg12683173 chr7:69063404 AUTS2 0.3 6.13 0.32 2.49e-9 Liver disease severity in Alagille syndrome; CRC trans rs11581859 0.950 rs17392625 chr1:99381704 T/C cg12183875 chr3:169587454 LRRC31 0.27 6.2 0.32 1.74e-9 Response to cognitive-behavioural therapy in anxiety disorder; CRC cis rs35306767 0.903 rs11815185 chr10:923617 T/A cg26597838 chr10:835615 NA 0.94 11.56 0.54 3.59e-26 Eosinophil percentage of granulocytes; CRC trans rs656319 0.559 rs17689007 chr8:9974824 G/A cg06636001 chr8:8085503 FLJ10661 -0.47 -6.72 -0.35 8.04e-11 Myopia (pathological); CRC cis rs4481887 0.927 rs11204631 chr1:248479530 A/G cg13385794 chr1:248469461 NA 0.39 6.74 0.35 7.22e-11 Common traits (Other); CRC cis rs8105895 0.935 rs62111034 chr19:22284720 A/C cg02912127 chr19:22235281 ZNF257 -0.41 -5.7 -0.3 2.62e-8 Body mass index (change over time); CRC cis rs11864453 0.611 rs9926927 chr16:72130556 G/T cg23815491 chr16:72088622 HP 0.51 7.78 0.39 9.45e-14 Fibrinogen levels; CRC cis rs8060686 0.641 rs73612222 chr16:68216072 A/G cg08314208 chr16:67682810 RLTPR -0.55 -6.14 -0.32 2.34e-9 HDL cholesterol;Metabolic syndrome; CRC cis rs10927875 0.597 rs61782184 chr1:16150976 G/A cg21385522 chr1:16154831 NA -1.1 -19.24 -0.73 8.63e-56 Dilated cardiomyopathy; CRC cis rs11098499 0.863 rs11947234 chr4:120474859 A/G cg09307838 chr4:120376055 NA 0.68 10.08 0.49 5.22e-21 Corneal astigmatism; CRC cis rs752010 0.905 rs2038977 chr1:42094659 A/G cg06885757 chr1:42089581 HIVEP3 0.53 9.26 0.45 2.64e-18 Lupus nephritis in systemic lupus erythematosus; CRC cis rs4819052 0.851 rs9977178 chr21:46664531 G/T cg19498844 chr21:46707878 POFUT2;LOC642852 0.75 11.06 0.52 2.19e-24 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; CRC cis rs10504229 0.683 rs62621195 chr8:58133964 G/A cg21724239 chr8:58056113 NA 0.49 6.81 0.35 4.75e-11 Developmental language disorder (linguistic errors); CRC cis rs2276314 0.512 rs1789515 chr18:33635893 G/A cg19628046 chr18:33552617 C18orf21 -0.39 -6.0 -0.31 5.21e-9 Endometriosis;Drug-induced torsades de pointes; CRC cis rs7618915 0.547 rs34173654 chr3:52634605 T/C cg18099408 chr3:52552593 STAB1 -0.45 -7.3 -0.37 2.19e-12 Bipolar disorder; CRC cis rs6460942 0.908 rs77034890 chr7:12244506 A/T cg06484146 chr7:12443880 VWDE -0.65 -6.36 -0.33 6.91e-10 Coronary artery disease; CRC cis rs10504229 0.512 rs117968470 chr8:58014651 C/G cg11062466 chr8:58055876 NA 0.53 6.58 0.34 1.85e-10 Developmental language disorder (linguistic errors); CRC cis rs2072499 1.000 rs2072499 chr1:156169610 A/G cg25208724 chr1:156163844 SLC25A44 1.08 26.29 0.82 7.78e-83 Testicular germ cell tumor; CRC cis rs4731207 0.698 rs7781148 chr7:124458044 G/A cg23710748 chr7:124431027 NA 0.38 6.08 0.32 3.42e-9 Cutaneous malignant melanoma; CRC cis rs12760731 0.623 rs61520802 chr1:178428494 G/A cg00404053 chr1:178313656 RASAL2 0.7 8.74 0.43 1.21e-16 Obesity-related traits; CRC cis rs10504229 0.595 rs77615399 chr8:58117394 C/G cg02725872 chr8:58115012 NA -0.64 -11.55 -0.54 3.85e-26 Developmental language disorder (linguistic errors); CRC cis rs4285028 0.848 rs77630152 chr3:121681194 C/T cg11130432 chr3:121712080 ILDR1 -0.51 -6.68 -0.35 9.97e-11 Multiple sclerosis; CRC cis rs6495122 0.618 rs4886413 chr15:75262310 G/C cg09165964 chr15:75287851 SCAMP5 0.55 8.26 0.41 3.58e-15 Caffeine consumption;Diastolic blood pressure;Coffee consumption; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg05655935 chr10:93683722 BTAF1 0.36 6.02 0.31 4.78e-9 Liver disease severity in Alagille syndrome; CRC cis rs11098499 0.865 rs9996417 chr4:120295862 T/C cg09307838 chr4:120376055 NA 0.71 10.88 0.51 9.53e-24 Corneal astigmatism; CRC trans rs2228479 0.850 rs62054610 chr16:89816920 G/A cg21302420 chr1:112162376 RAP1A 0.72 6.01 0.31 5.05e-9 Skin colour saturation; CRC cis rs4803468 1.000 rs10853751 chr19:41903220 G/A cg09537434 chr19:41945824 ATP5SL -0.97 -18.7 -0.72 1.09e-53 Height; CRC cis rs501120 1.000 rs573141 chr10:44758587 G/A cg09554077 chr10:44749378 NA 0.78 12.0 0.55 9.18e-28 Coronary artery disease;Coronary heart disease; CRC cis rs1552244 1.000 rs112509186 chr3:10156533 A/G cg00166722 chr3:10149974 C3orf24 0.7 9.17 0.45 5.21e-18 Alzheimer's disease; CRC cis rs6912958 0.781 rs9450712 chr6:88193175 C/T cg12350822 chr6:88032061 C6orf162;GJB7 -0.32 -5.99 -0.31 5.63e-9 Monocyte percentage of white cells; CRC cis rs35883536 0.626 rs10783140 chr1:101042083 A/G cg06223162 chr1:101003688 GPR88 -0.35 -6.37 -0.33 6.44e-10 Monocyte count; CRC cis rs7584330 0.554 rs112402109 chr2:238429058 A/G cg08992911 chr2:238395768 MLPH 0.52 5.66 0.3 3.21e-8 Prostate cancer; CRC trans rs10242455 1.000 rs2301889 chr7:98931105 A/G cg09045935 chr12:6379348 NA 0.77 7.22 0.37 3.56e-12 Blood metabolite levels; CRC cis rs7191700 0.511 rs8058983 chr16:11360849 A/G cg00044050 chr16:11439710 C16orf75 -0.56 -8.19 -0.41 5.84e-15 Multiple sclerosis; CRC cis rs2073300 0.609 rs56334525 chr20:23365812 A/G cg12062639 chr20:23401060 NAPB 0.73 6.76 0.35 6.48e-11 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs79387448 0.655 rs79144324 chr2:102932814 G/A cg09003973 chr2:102972529 NA 0.97 10.14 0.49 3.4e-21 Gut microbiota (bacterial taxa); CRC cis rs2033711 0.503 rs7254299 chr19:58884965 A/G cg00825309 chr19:58991885 ZNF446 -0.39 -5.78 -0.3 1.73e-8 Uric acid clearance; CRC cis rs6772849 0.930 rs4857916 chr3:128376014 C/G cg08795948 chr3:128337044 NA 0.36 6.28 0.33 1.06e-9 Monocyte percentage of white cells;Monocyte count; CRC cis rs9549328 0.700 rs4907568 chr13:113617574 A/T cg24588162 chr13:113633484 MCF2L -0.36 -6.69 -0.35 9.8e-11 Systolic blood pressure; CRC cis rs10450586 0.863 rs7481109 chr11:27298062 A/G cg10370305 chr11:27303972 NA 0.38 6.23 0.32 1.42e-9 Total body bone mineral density; CRC cis rs7662987 0.517 rs2602883 chr4:100040914 A/T cg13256891 chr4:100009986 ADH5 0.64 8.62 0.43 2.84e-16 Smoking initiation; CRC cis rs939658 0.805 rs11634679 chr15:79432475 T/C cg17916960 chr15:79447300 NA -0.46 -7.45 -0.38 8.11e-13 Refractive error; CRC cis rs72634258 0.945 rs67717282 chr1:8041290 C/T cg26816564 chr1:7831052 VAMP3 0.54 6.01 0.31 5e-9 Inflammatory bowel disease; CRC cis rs394563 0.601 rs382720 chr6:149795261 C/T cg07828024 chr6:149772892 ZC3H12D 0.36 6.12 0.32 2.68e-9 Dupuytren's disease; CRC cis rs17401966 0.838 rs4846197 chr1:10282166 G/A cg19773385 chr1:10388646 KIF1B -0.65 -10.42 -0.5 3.66e-22 Hepatocellular carcinoma; CRC cis rs847577 0.609 rs6965016 chr7:97807882 C/A cg00277769 chr7:97922759 BAIAP2L1 -0.41 -6.76 -0.35 6.16e-11 Breast cancer; CRC trans rs7618501 0.538 rs9856572 chr3:50109073 A/T cg21665057 chr3:196295764 WDR53;FBXO45 -0.55 -8.62 -0.43 2.88e-16 Intelligence (multi-trait analysis); CRC cis rs473651 0.904 rs501333 chr2:239336045 G/A cg18131467 chr2:239335373 ASB1 1.04 23.84 0.8 1.16e-73 Multiple system atrophy; CRC cis rs7647973 0.626 rs9829155 chr3:49817450 T/C cg03060546 chr3:49711283 APEH -0.65 -7.89 -0.4 4.56e-14 Menarche (age at onset); CRC cis rs9911578 1.000 rs8071916 chr17:56660279 A/G cg12560992 chr17:57184187 TRIM37 0.88 16.19 0.67 9.31e-44 Intelligence (multi-trait analysis); CRC cis rs11098499 0.826 rs12511640 chr4:120251248 T/C cg24375607 chr4:120327624 NA 0.47 7.6 0.39 3.06e-13 Corneal astigmatism; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg22753607 chr9:37120306 ZCCHC7 0.48 6.26 0.33 1.23e-9 Thyroid stimulating hormone; CRC cis rs6912958 0.630 rs4707377 chr6:88280332 C/T cg08069147 chr6:88032118 GJB7;C6orf162 -0.57 -8.57 -0.43 4.19e-16 Monocyte percentage of white cells; CRC cis rs9486715 0.867 rs4839842 chr6:96955387 A/T cg18709589 chr6:96969512 KIAA0776 0.49 7.2 0.37 4.09e-12 Headache; CRC cis rs769267 0.831 rs2872878 chr19:19480521 G/C cg01262667 chr19:19385393 TM6SF2 -0.4 -6.59 -0.34 1.72e-10 Tonsillectomy; CRC cis rs12760731 0.565 rs12037429 chr1:178224741 C/T cg00404053 chr1:178313656 RASAL2 1.03 10.81 0.51 1.61e-23 Obesity-related traits; CRC cis rs6912958 0.712 rs2754260 chr6:88397666 T/C cg08069147 chr6:88032118 GJB7;C6orf162 -0.54 -7.91 -0.4 3.92e-14 Monocyte percentage of white cells; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg19304507 chr22:30278992 MTMR3 0.4 6.12 0.32 2.68e-9 Liver disease severity in Alagille syndrome; CRC cis rs7020830 0.830 rs308499 chr9:37348059 C/G cg14294708 chr9:37120828 ZCCHC7 1.01 19.81 0.74 4.7e-58 Schizophrenia; CRC cis rs3820068 0.581 rs1122386 chr1:15946877 C/T cg27534772 chr1:16042836 PLEKHM2 0.55 11.0 0.52 3.66e-24 Systolic blood pressure; CRC trans rs4263408 0.934 rs9683743 chr4:39703194 A/C cg17496447 chr4:144435124 SMARCA5 -0.38 -6.18 -0.32 1.89e-9 Plasma amyloid beta peptide concentrations (ABx-40); CRC cis rs743757 1.000 rs1107265 chr3:50431995 A/C cg08207895 chr3:50388901 TUSC4;CYB561D2 0.44 6.52 0.34 2.64e-10 Diastolic blood pressure; CRC cis rs801193 0.548 rs6975044 chr7:66227482 C/T cg18252515 chr7:66147081 NA -0.43 -6.15 -0.32 2.28e-9 Aortic root size; CRC cis rs875971 0.545 rs75840613 chr7:65841386 G/A cg03233332 chr7:66118400 NA -0.45 -6.16 -0.32 2.07e-9 Aortic root size; CRC cis rs73195822 0.527 rs55728229 chr12:111169374 T/A cg12870014 chr12:110450643 ANKRD13A 0.74 7.96 0.4 2.88e-14 Itch intensity from mosquito bite; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg05572020 chr16:3989254 NA 0.48 6.44 0.33 4.25e-10 Anxiety disorder; CRC cis rs7221595 0.877 rs7219437 chr17:4050138 A/G cg05562828 chr17:3906858 NA 0.42 5.92 0.31 8.29e-9 Functional impairment in major depressive disorder, bipolar disorder and schizophrenia; CRC cis rs10504229 0.906 rs67389108 chr8:58193718 G/A cg02725872 chr8:58115012 NA -0.44 -7.86 -0.4 5.64e-14 Developmental language disorder (linguistic errors); CRC trans rs948562 1.000 rs79475579 chr11:58295900 G/A cg26660744 chr1:1573181 CDK11B 0.53 6.2 0.32 1.69e-9 Lymphoma; CRC cis rs58688157 0.880 rs12272314 chr11:590648 A/G cg02461776 chr11:598696 PHRF1 0.41 5.61 0.3 4.33e-8 Systemic lupus erythematosus; CRC cis rs9916302 0.752 rs6503513 chr17:37561613 A/G cg00129232 chr17:37814104 STARD3 0.54 7.34 0.38 1.68e-12 Glomerular filtration rate (creatinine); CRC trans rs951252 0.504 rs11734405 chr4:146081096 C/T cg09019002 chr7:102715232 ARMC10;FBXL13 0.48 6.26 0.33 1.23e-9 Hip circumference; CRC cis rs12477438 0.834 rs1563108 chr2:99701153 A/G cg14399236 chr2:99771627 LIPT1;TSGA10 -0.6 -8.46 -0.42 8.97e-16 Chronic sinus infection; CRC cis rs10089 0.904 rs3087889 chr5:127524944 T/A cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.7 9.63 0.47 1.63e-19 Ileal carcinoids; CRC cis rs12545109 0.879 rs893234 chr8:57363885 G/A cg09654669 chr8:57350985 NA -0.44 -5.95 -0.31 6.89e-9 Obesity-related traits; CRC cis rs6912958 0.702 rs6906769 chr6:88235949 T/C cg08069147 chr6:88032118 GJB7;C6orf162 -0.56 -8.4 -0.42 1.37e-15 Monocyte percentage of white cells; CRC cis rs7274811 0.779 rs13039908 chr20:32052070 G/A cg03904042 chr20:32255491 NECAB3;C20orf134 -0.42 -5.98 -0.31 5.81e-9 Height; CRC cis rs4664293 0.867 rs3771718 chr2:160636908 A/G cg08347373 chr2:160653686 CD302 -0.47 -7.47 -0.38 7.5e-13 Monocyte percentage of white cells; CRC cis rs1129187 0.902 rs10948059 chr6:42928461 C/T cg03790207 chr6:42947109 PEX6 -0.46 -6.73 -0.35 7.65e-11 Alzheimer's disease in APOE e4+ carriers; CRC cis rs6500602 0.789 rs2404546 chr16:4479734 C/G cg08645402 chr16:4508243 NA 0.55 9.21 0.45 3.92e-18 Schizophrenia; CRC cis rs17270561 0.636 rs9379779 chr6:25695441 G/T cg16482183 chr6:26056742 HIST1H1C 0.71 8.65 0.43 2.38e-16 Iron status biomarkers; CRC cis rs7772486 0.875 rs13198450 chr6:146370524 C/A cg23711669 chr6:146136114 FBXO30 0.68 11.86 0.55 2.95e-27 Lobe attachment (rater-scored or self-reported); CRC cis rs9325144 0.647 rs870431 chr12:38953073 T/C cg13010199 chr12:38710504 ALG10B -0.4 -5.62 -0.3 4.09e-8 Morning vs. evening chronotype; CRC cis rs2415984 0.622 rs1955262 chr14:46940639 A/G cg14871534 chr14:47121158 RPL10L -0.44 -6.21 -0.32 1.6e-9 Number of children ever born; CRC cis rs1670533 1.000 rs10084849 chr4:1053586 T/C cg27284194 chr4:1044797 NA 0.49 6.06 0.32 3.75e-9 Recombination rate (females); CRC cis rs2197308 0.740 rs11182967 chr12:37935140 A/C cg13010199 chr12:38710504 ALG10B 0.44 5.62 0.3 4.08e-8 Morning vs. evening chronotype; CRC cis rs59918340 0.728 rs35257077 chr8:142235049 C/T cg17298326 chr8:142245477 NA 0.4 5.97 0.31 6.28e-9 Immature fraction of reticulocytes; CRC cis rs1046896 0.739 rs28459016 chr17:80741194 G/A cg08200770 chr17:80723486 TBCD -0.5 -7.83 -0.4 6.79e-14 Glycated hemoglobin levels; CRC cis rs6952808 0.893 rs35487994 chr7:1920171 G/A cg02951883 chr7:2050386 MAD1L1 -0.75 -12.4 -0.56 3.15e-29 Bipolar disorder and schizophrenia; CRC cis rs7512552 0.839 rs1260367 chr1:150344514 C/T cg15654264 chr1:150340011 RPRD2 0.58 8.56 0.43 4.48e-16 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg23781003 chr4:120988207 MAD2L1 0.48 6.33 0.33 8.14e-10 Thyroid stimulating hormone; CRC cis rs10751667 0.643 rs7479473 chr11:929111 C/T ch.11.42038R chr11:967971 AP2A2 0.6 10.22 0.49 1.74e-21 Alzheimer's disease (late onset); CRC cis rs2404602 0.692 rs4886503 chr15:77108874 C/T cg22467129 chr15:76604101 ETFA 0.37 6.14 0.32 2.37e-9 Blood metabolite levels; CRC trans rs2228479 0.850 rs11639788 chr16:89807543 G/A cg21302420 chr1:112162376 RAP1A 0.72 5.96 0.31 6.38e-9 Skin colour saturation; CRC cis rs1865760 0.865 rs2164485 chr6:25952106 G/A cg17691542 chr6:26056736 HIST1H1C 0.55 8.29 0.42 2.87e-15 Height; CRC cis rs9303401 0.659 rs7216648 chr17:56790858 C/T cg02118635 chr17:56770003 RAD51C;TEX14 0.79 10.13 0.49 3.5e-21 Cognitive test performance; CRC cis rs6693567 0.507 rs9436120 chr1:150473084 T/C cg04165759 chr1:150448943 RPRD2 0.36 5.87 0.31 1.05e-8 Migraine; CRC cis rs3741151 0.773 rs73544711 chr11:73164870 T/A cg17517138 chr11:73019481 ARHGEF17 1.04 8.44 0.42 1.01e-15 GIP levels in response to oral glucose tolerance test (120 minutes); CRC cis rs12497850 0.931 rs7431710 chr3:48935583 G/A cg20833759 chr3:49053208 WDR6;DALRD3 0.48 8.17 0.41 6.8e-15 Parkinson's disease; CRC cis rs8005677 1.000 rs8014936 chr14:23375145 A/G cg01529538 chr14:23388837 RBM23 0.39 6.19 0.32 1.78e-9 Cognitive ability (multi-trait analysis); CRC cis rs28386778 0.897 rs2584624 chr17:61904546 A/G cg06601766 chr17:61851465 DDX42;CCDC47 0.44 5.95 0.31 6.97e-9 Prudent dietary pattern; CRC cis rs9435341 0.826 rs17496332 chr1:107546375 C/T cg09367891 chr1:107599246 PRMT6 -0.62 -9.1 -0.45 8.95e-18 Facial morphology (factor 21, depth of nasal alae); CRC cis rs11212617 1.000 rs11212610 chr11:108274593 T/C cg01991180 chr11:108092276 ATM;NPAT 0.41 5.99 0.31 5.52e-9 Response to metformin in type 2 diabetes (glycemic); CRC cis rs8062405 1.000 rs4788095 chr16:28831359 T/C cg16576597 chr16:28551801 NUPR1 0.49 7.07 0.36 9.42e-12 Cognitive ability (multi-trait analysis);Cognitive ability; CRC cis rs7927771 0.524 rs7122182 chr11:47843133 A/C cg20307385 chr11:47447363 PSMC3 -0.46 -6.74 -0.35 7.09e-11 Subjective well-being; CRC cis rs4731207 0.623 rs12706629 chr7:124574045 A/G cg23710748 chr7:124431027 NA -0.39 -6.19 -0.32 1.8e-9 Cutaneous malignant melanoma; CRC trans rs2727020 0.587 rs1164658 chr11:49298551 C/A cg21153622 chr11:89784906 NA 0.42 6.93 0.36 2.26e-11 Coronary artery disease; CRC cis rs12476592 0.543 rs12713494 chr2:63698162 G/T cg10828910 chr2:63850056 LOC388955 0.47 5.69 0.3 2.8e-8 Childhood ear infection; CRC cis rs8180040 1.000 rs7613282 chr3:47389409 C/T cg10298567 chr3:47292165 KIF9 0.44 7.24 0.37 3.21e-12 Colorectal cancer; CRC cis rs6456156 0.586 rs12213801 chr6:167474084 T/A cg07741184 chr6:167504864 NA 0.38 6.8 0.35 4.95e-11 Primary biliary cholangitis; CRC cis rs713477 0.967 rs7146170 chr14:55914054 G/C cg21836586 chr14:55907198 TBPL2 0.3 5.6 0.3 4.51e-8 Pediatric bone mineral content (femoral neck); CRC cis rs7216064 0.861 rs73352810 chr17:65875184 G/A cg12091567 chr17:66097778 LOC651250 -0.61 -7.68 -0.39 1.84e-13 Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma; CRC cis rs10779751 0.575 rs2791655 chr1:11128654 A/G cg08854313 chr1:11322531 MTOR -0.59 -8.39 -0.42 1.44e-15 Body mass index; CRC cis rs13118159 0.556 rs4974615 chr4:1373551 A/G cg02475777 chr4:1388615 CRIPAK -0.46 -6.1 -0.32 2.94e-9 Longevity; CRC cis rs7647973 1.000 rs7619789 chr3:49476263 T/C cg07690219 chr3:49449608 TCTA;RHOA -0.53 -6.13 -0.32 2.56e-9 Menarche (age at onset); CRC cis rs763121 0.853 rs2076028 chr22:39150450 G/A cg06544989 chr22:39130855 UNC84B 0.47 7.0 0.36 1.45e-11 Menopause (age at onset); CRC cis rs7412746 0.658 rs2089082 chr1:150800090 T/G cg10589385 chr1:150898437 SETDB1 0.31 6.38 0.33 6.04e-10 Melanoma; CRC cis rs10464366 0.544 rs34866559 chr7:39166071 G/A cg21665744 chr7:39171113 POU6F2 0.45 5.96 0.31 6.67e-9 IgG glycosylation; CRC trans rs7615952 0.736 rs13063122 chr3:125643860 G/A cg02007433 chr3:129722099 NA -0.46 -5.98 -0.31 5.71e-9 Blood pressure (smoking interaction); CRC cis rs787274 0.718 rs4979178 chr9:115644335 G/C cg13803584 chr9:115635662 SNX30 -0.6 -6.2 -0.32 1.72e-9 Age-related hearing impairment (SNP x SNP interaction); CRC trans rs7395662 0.517 rs11039885 chr11:48647107 A/G cg03929089 chr4:120376271 NA -0.46 -6.58 -0.34 1.83e-10 HDL cholesterol; CRC cis rs6089584 0.819 rs1467593 chr20:60601432 T/G cg06108461 chr20:60628389 TAF4 0.84 12.79 0.58 1.09e-30 Body mass index; CRC cis rs7666738 1.000 rs880473 chr4:98922596 C/T cg17366294 chr4:99064904 C4orf37 0.47 7.47 0.38 7.28e-13 Colonoscopy-negative controls vs population controls; CRC cis rs992157 0.835 rs6707559 chr2:219142773 C/T cg13835894 chr2:219148914 PNKD;TMBIM1 0.33 6.33 0.33 8.2e-10 Colorectal cancer; CRC cis rs972578 1.000 rs2284097 chr22:43400006 C/G cg01576275 chr22:43409880 NA -0.43 -6.76 -0.35 6.22e-11 Mean platelet volume; CRC cis rs939584 1.000 rs10190052 chr2:646674 T/C cg03610516 chr2:642275 NA 0.42 5.88 0.31 9.94e-9 Body mass index; CRC cis rs875971 0.505 rs1167386 chr7:65513096 G/A cg18912574 chr7:65842487 NCRNA00174 -0.37 -6.2 -0.32 1.69e-9 Aortic root size; CRC cis rs11190604 1.000 rs11292 chr10:102313607 A/G cg16342193 chr10:102329863 NA -0.35 -5.9 -0.31 8.84e-9 Palmitoleic acid (16:1n-7) levels; CRC cis rs3820068 0.603 rs1122387 chr1:15947282 T/C cg13390004 chr1:15929781 NA 0.5 7.11 0.37 7.21e-12 Systolic blood pressure; CRC cis rs35146811 0.807 rs6465761 chr7:99620277 G/C cg13334819 chr7:99746414 C7orf59 -0.5 -6.93 -0.36 2.26e-11 Coronary artery disease; CRC cis rs853679 0.517 rs9393894 chr6:28112562 A/G cg02683197 chr6:28174875 NA 0.87 10.73 0.51 3.25e-23 Depression; CRC trans rs561341 1.000 rs72823789 chr17:30284084 G/A cg27661571 chr11:113659931 NA -0.96 -11.24 -0.53 5.07e-25 Hip circumference adjusted for BMI; CRC cis rs6570726 0.935 rs7757387 chr6:145816726 G/T cg05347473 chr6:146136440 FBXO30 0.37 5.91 0.31 8.46e-9 Lobe attachment (rater-scored or self-reported); CRC cis rs35110281 0.776 rs1073522 chr21:45009219 T/A cg04455712 chr21:45112962 RRP1B 0.42 8.26 0.41 3.55e-15 Mean corpuscular volume; CRC cis rs75920871 0.588 rs4548653 chr11:116903316 G/A cg20608306 chr11:116969690 SIK3 -0.31 -5.66 -0.3 3.23e-8 Subjective well-being; CRC cis rs78456975 1.000 rs13392535 chr2:1542634 G/T cg26248373 chr2:1572462 NA -0.62 -6.5 -0.34 2.96e-10 Placebo response in major depressive disorder (% change in symptom score); CRC cis rs9469578 0.892 rs73743334 chr6:33714094 G/C cg18708504 chr6:33715942 IP6K3 0.66 7.56 0.38 4e-13 Phosphorus levels; CRC cis rs2075371 1.000 rs2505 chr7:133979552 C/T cg11752832 chr7:134001865 SLC35B4 0.49 7.54 0.38 4.63e-13 Mean platelet volume; CRC cis rs9611565 0.608 rs202652 chr22:41838792 A/G cg06481639 chr22:41940642 POLR3H 0.5 6.17 0.32 1.99e-9 Vitiligo; CRC cis rs2153535 0.580 rs9505448 chr6:8459804 A/G cg07606381 chr6:8435919 SLC35B3 0.69 11.15 0.52 1.04e-24 Motion sickness; CRC trans rs7615952 0.558 rs7641353 chr3:125339879 T/C cg02560186 chr11:3602584 NA -0.63 -9.53 -0.47 3.69e-19 Blood pressure (smoking interaction); CRC cis rs6952809 0.532 rs10272548 chr7:2439467 G/A cg23289794 chr7:2394357 EIF3B -0.79 -9.51 -0.46 4.25e-19 Multiple sclerosis; CRC cis rs9311474 0.507 rs6787154 chr3:52784416 C/T cg08222913 chr3:52553049 STAB1 -0.33 -6.1 -0.32 2.98e-9 Electroencephalogram traits; CRC cis rs2832191 0.679 rs2705659 chr21:30363908 G/C cg24692254 chr21:30365293 RNF160 0.85 15.9 0.66 1.23e-42 Dental caries; CRC cis rs9311474 0.629 rs7636227 chr3:52566682 G/A cg11645453 chr3:52864694 ITIH4 0.34 6.4 0.33 5.31e-10 Electroencephalogram traits; CRC cis rs6121246 0.697 rs6120970 chr20:30232452 C/T cg13852791 chr20:30311386 BCL2L1 0.63 9.48 0.46 5.15e-19 Mean corpuscular hemoglobin; CRC cis rs7259376 0.902 rs10409947 chr19:22512518 G/A cg02657401 chr19:22469223 NA -0.37 -8.16 -0.41 7.14e-15 Menopause (age at onset); CRC cis rs990171 0.865 rs6717915 chr2:103079619 A/C cg03938978 chr2:103052716 IL18RAP 0.46 5.88 0.31 1e-8 Lymphocyte counts; CRC cis rs6500602 0.627 rs9934267 chr16:4534366 G/C cg08645402 chr16:4508243 NA 0.55 8.13 0.41 8.77e-15 Schizophrenia; CRC cis rs1707322 0.721 rs4330955 chr1:46217485 G/C cg06784218 chr1:46089804 CCDC17 0.66 12.27 0.56 9.04e-29 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); CRC cis rs8141529 0.504 rs6005915 chr22:29233262 A/G cg15103426 chr22:29168792 CCDC117 0.47 6.07 0.32 3.49e-9 Lymphocyte counts; CRC cis rs1448094 1.000 rs7305284 chr12:86343786 C/T cg18827107 chr12:86230957 RASSF9 -0.37 -6.11 -0.32 2.84e-9 Major depressive disorder; CRC cis rs9611565 0.512 rs2899349 chr22:42164660 T/C cg03806693 chr22:41940476 POLR3H 1.1 13.52 0.6 2e-33 Vitiligo; CRC cis rs12519773 0.502 rs4613686 chr5:92498497 A/G cg18783429 chr5:92414398 NA 0.27 5.84 0.31 1.26e-8 Migraine; CRC cis rs651907 0.557 rs7612283 chr3:101434919 C/T cg11279151 chr3:101281821 RG9MTD1 -0.55 -7.58 -0.39 3.46e-13 Colorectal cancer; CRC cis rs7618915 0.547 rs12496634 chr3:52709259 A/C cg15147215 chr3:52552868 STAB1 -0.63 -10.4 -0.5 4.44e-22 Bipolar disorder; CRC cis rs992157 0.560 rs4674275 chr2:219097738 G/A cg00012203 chr2:219082015 ARPC2 -0.54 -8.52 -0.43 5.77e-16 Colorectal cancer; CRC cis rs7149337 0.780 rs4369569 chr14:51689181 C/G cg18683604 chr14:51561293 TRIM9 -0.32 -6.22 -0.32 1.47e-9 Cancer; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg00949670 chr12:120967105 COQ5 0.45 5.96 0.31 6.45e-9 Thyroid stimulating hormone; CRC cis rs6679356 0.789 rs10889683 chr1:67809317 A/T cg24364144 chr1:67875067 SERBP1 0.42 6.35 0.33 6.96e-10 Primary biliary cholangitis; CRC cis rs7777484 0.534 rs2533886 chr7:2834869 C/T cg09658497 chr7:2847517 GNA12 -0.37 -6.15 -0.32 2.3e-9 Height; CRC cis rs72772090 0.539 rs56120748 chr5:96110622 C/T cg17330273 chr5:96107758 CAST;ERAP1 -0.68 -6.02 -0.32 4.61e-9 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); CRC cis rs9388451 0.626 rs7748729 chr6:126077381 C/T cg05901451 chr6:126070800 HEY2 -0.53 -8.81 -0.44 7.15e-17 Brugada syndrome; CRC trans rs9747201 0.962 rs11656153 chr17:80072950 G/A cg07393940 chr7:158741817 NA -0.55 -7.89 -0.4 4.55e-14 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs6570726 0.791 rs12208019 chr6:145935572 T/C cg13319975 chr6:146136371 FBXO30 -0.48 -7.06 -0.36 9.75e-12 Lobe attachment (rater-scored or self-reported); CRC trans rs561341 1.000 rs113676348 chr17:30244327 A/G cg27661571 chr11:113659931 NA -0.8 -9.48 -0.46 5.16e-19 Hip circumference adjusted for BMI; CRC cis rs2730245 1.000 rs2730245 chr7:158724789 G/C cg24397884 chr7:158709396 WDR60 -0.97 -16.94 -0.68 9.95e-47 Height; CRC cis rs9911578 0.835 rs1990008 chr17:56459408 C/G cg12560992 chr17:57184187 TRIM37 -0.84 -14.41 -0.62 7.84e-37 Intelligence (multi-trait analysis); CRC cis rs17152411 0.947 rs7079199 chr10:126590820 A/C cg07906193 chr10:126599966 NA 0.59 5.78 0.3 1.71e-8 Height; CRC cis rs2013441 1.000 rs3850783 chr17:20184501 C/T cg13482628 chr17:19912719 NA 0.39 5.85 0.31 1.17e-8 Obesity-related traits; CRC cis rs6951245 1.000 rs78185558 chr7:1090183 G/C cg20603222 chr7:1096387 C7orf50;GPR146 -0.62 -7.44 -0.38 8.57e-13 C-reactive protein levels or total cholesterol levels (pleiotropy); CRC cis rs2243480 1.000 rs6958420 chr7:65751171 A/G cg25985355 chr7:65971099 NA 0.51 5.72 0.3 2.46e-8 Diabetic kidney disease; CRC cis rs870825 0.616 rs28450662 chr4:185638900 G/A cg04058563 chr4:185651563 MLF1IP 0.73 9.56 0.47 2.93e-19 Blood protein levels; CRC cis rs6667605 0.527 rs6673993 chr1:2552071 T/C cg20673091 chr1:2541236 MMEL1 0.36 5.83 0.31 1.34e-8 Inflammatory bowel disease;Ulcerative colitis; CRC cis rs2108622 0.727 rs12611242 chr19:15978564 G/A cg13772218 chr19:15982569 NA 0.48 6.72 0.35 8.16e-11 Circulating phylloquinone levels;Vitamin E levels;Acenocoumarol maintenance dosage;Response to Vitamin E supplementation;Metabolite levels;Warfarin maintenance dose; CRC cis rs919433 0.713 rs6714697 chr2:198484486 C/T cg10820045 chr2:198174542 NA 0.43 7.46 0.38 7.97e-13 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); CRC cis rs270601 0.710 rs371709 chr5:131583240 A/G cg18301423 chr5:131593218 PDLIM4 0.45 7.78 0.39 9.31e-14 Acylcarnitine levels; CRC cis rs4664293 0.967 rs13032135 chr2:160532099 T/C cg08347373 chr2:160653686 CD302 -0.37 -6.08 -0.32 3.32e-9 Monocyte percentage of white cells; CRC cis rs875971 0.571 rs160641 chr7:65577346 G/A cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.59 -7.69 -0.39 1.7e-13 Aortic root size; CRC trans rs773506 0.965 rs298718 chr9:94081674 A/G cg01894875 chr1:2121521 C1orf86;LOC100128003 0.39 6.01 0.31 5.03e-9 Type 2 diabetes nephropathy; CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg21123913 chr4:89513664 HERC3 0.41 6.96 0.36 1.85e-11 Liver disease severity in Alagille syndrome; CRC cis rs7937682 0.924 rs10891283 chr11:111527672 A/G cg09085632 chr11:111637200 PPP2R1B -1.0 -20.15 -0.74 2.29e-59 Primary sclerosing cholangitis; CRC trans rs10411161 0.702 rs8110531 chr19:52383510 C/T cg22319618 chr22:45562946 NUP50 -0.68 -7.53 -0.38 4.85e-13 Breast cancer; CRC cis rs6088580 0.634 rs6579165 chr20:32994715 A/G cg24642439 chr20:33292090 TP53INP2 -0.37 -6.31 -0.33 8.76e-10 Glomerular filtration rate (creatinine); CRC cis rs2180341 0.889 rs9321074 chr6:127618019 G/A cg27446573 chr6:127587934 RNF146 0.99 14.76 0.63 3.48e-38 Breast cancer; CRC cis rs6952808 0.825 rs11761818 chr7:1935273 C/T cg00106254 chr7:1943704 MAD1L1 -0.51 -7.7 -0.39 1.5700000000000001e-13 Bipolar disorder and schizophrenia; CRC trans rs1814175 0.935 rs11040465 chr11:49689323 C/T cg15704280 chr7:45808275 SEPT13 -0.96 -17.66 -0.7 1.48e-49 Height; CRC cis rs6484504 0.532 rs7116443 chr11:31283170 T/C cg14844989 chr11:31128820 NA -0.34 -6.05 -0.32 3.85e-9 Red blood cell count; CRC cis rs763014 0.932 rs2269560 chr16:682442 A/C cg09263875 chr16:632152 PIGQ 0.8 12.82 0.58 8.77e-31 Height; CRC cis rs13118159 0.509 rs4974554 chr4:1356967 A/C cg20887711 chr4:1340912 KIAA1530 0.76 11.09 0.52 1.74e-24 Longevity; CRC trans rs1455244 0.700 rs7229302 chr18:11508904 G/T cg01932091 chr1:29213675 EPB41 0.39 6.02 0.31 4.54e-9 Schizophrenia; CRC cis rs17023223 0.537 rs10923766 chr1:119726932 G/A cg05756136 chr1:119680316 WARS2 -0.52 -7.14 -0.37 6e-12 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for BMI in active individuals; CRC cis rs6011002 0.564 rs2260045 chr20:62343013 T/C cg01176363 chr20:62369445 LIME1 -0.72 -5.67 -0.3 3.14e-8 Dental caries; CRC cis rs10504229 0.683 rs56235637 chr8:58106008 T/C cg05313129 chr8:58192883 C8orf71 -0.43 -5.87 -0.31 1.09e-8 Developmental language disorder (linguistic errors); CRC cis rs4319547 0.656 rs10744209 chr12:122931568 G/A cg23029597 chr12:123009494 RSRC2 -0.55 -6.86 -0.35 3.34e-11 Body mass index; CRC cis rs6540559 0.546 rs74991018 chr1:210033790 T/G cg22029157 chr1:209979665 IRF6 0.61 6.77 0.35 5.84e-11 Cleft lip with or without cleft palate; CRC cis rs6089584 0.706 rs6089625 chr20:60620622 T/C cg06108461 chr20:60628389 TAF4 -0.9 -15.34 -0.65 1.98e-40 Body mass index; CRC cis rs7119 0.651 rs8041398 chr15:77839173 A/G cg27398640 chr15:77910606 LINGO1 -0.4 -6.91 -0.36 2.56e-11 Type 2 diabetes; CRC cis rs7618915 0.571 rs33964154 chr3:52596914 A/G cg10802521 chr3:52805072 NEK4 -0.59 -9.16 -0.45 5.88e-18 Bipolar disorder; CRC cis rs2635047 0.638 rs16954921 chr18:44610526 G/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.37 5.84 0.31 1.24e-8 Educational attainment; CRC cis rs1957429 0.901 rs1467571 chr14:65347682 C/T cg23373153 chr14:65346875 NA 0.79 8.25 0.41 3.9e-15 Pediatric areal bone mineral density (radius); CRC cis rs1862618 0.713 rs832550 chr5:56182589 C/T cg18230493 chr5:56204884 C5orf35 -0.75 -9.27 -0.45 2.61e-18 Initial pursuit acceleration; CRC cis rs7618501 0.633 rs35065728 chr3:50009176 T/C cg24110177 chr3:50126178 RBM5 -0.51 -7.86 -0.4 5.61e-14 Intelligence (multi-trait analysis); CRC cis rs34375054 0.558 rs12578774 chr12:125681761 A/G cg02766259 chr12:125626809 AACS 0.4 6.74 0.35 6.9e-11 Post bronchodilator FEV1/FVC ratio; CRC cis rs11098499 0.954 rs7681544 chr4:120411255 T/C cg24375607 chr4:120327624 NA 0.49 7.5 0.38 6.06e-13 Corneal astigmatism; CRC cis rs734999 0.545 rs7368072 chr1:2556125 C/T cg18854424 chr1:2615690 NA 0.39 7.42 0.38 1.01e-12 Ulcerative colitis; CRC cis rs4319547 0.656 rs10773075 chr12:122814236 G/A cg23029597 chr12:123009494 RSRC2 -0.51 -6.24 -0.33 1.35e-9 Body mass index; CRC cis rs2456568 0.803 rs10765642 chr11:93640355 C/T cg26875233 chr11:93583750 C11orf90 0.29 5.74 0.3 2.13e-8 Response to serotonin reuptake inhibitors in major depressive disorder; CRC cis rs4974559 0.739 rs35571200 chr4:1268129 G/A cg02980000 chr4:1222292 CTBP1 -0.68 -8.0 -0.4 2.08e-14 Systolic blood pressure; CRC cis rs7827545 0.644 rs4909452 chr8:135521053 C/G cg17885191 chr8:135476712 NA -0.56 -7.45 -0.38 8.31e-13 Hypertension (SNP x SNP interaction); CRC cis rs8077889 0.871 rs8065043 chr17:41900984 G/A cg16892393 chr17:41919603 NA 0.47 7.24 0.37 3.23e-12 Triglycerides; CRC cis rs7584330 0.554 rs6760890 chr2:238400645 G/A cg14458575 chr2:238380390 NA 0.82 10.34 0.5 6.81e-22 Prostate cancer; CRC cis rs9302635 0.513 rs3812987 chr16:72158920 C/A cg23815491 chr16:72088622 HP 0.62 8.05 0.41 1.55e-14 Blood protein levels; CRC cis rs853679 0.517 rs2275508 chr6:28094731 T/C cg06470822 chr6:28175283 NA 0.98 12.98 0.58 2.22e-31 Depression; CRC cis rs10504229 0.683 rs17194995 chr8:58109220 A/C cg08219700 chr8:58056026 NA -0.53 -6.39 -0.33 5.55e-10 Developmental language disorder (linguistic errors); CRC cis rs9527 1.000 rs4919690 chr10:104616500 C/T cg15744005 chr10:104629667 AS3MT 0.41 6.98 0.36 1.68e-11 Arsenic metabolism; CRC cis rs7998202 0.667 rs282568 chr13:113371938 A/G cg01692110 chr13:113365389 ATP11A -0.51 -6.34 -0.33 7.55e-10 Glycated hemoglobin levels; CRC cis rs734999 0.967 rs10797433 chr1:2502010 T/C cg18854424 chr1:2615690 NA 0.34 6.35 0.33 7.02e-10 Ulcerative colitis; CRC cis rs1538970 0.774 rs67683090 chr1:45977803 T/G cg05343316 chr1:45956843 TESK2 0.76 9.97 0.48 1.21e-20 Platelet count; CRC cis rs9467711 0.651 rs13200797 chr6:26122957 G/A cg08501292 chr6:25962987 TRIM38 0.94 8.44 0.42 1.05e-15 Autism spectrum disorder or schizophrenia; CRC cis rs10791323 0.593 rs2156676 chr11:133715791 G/C cg03690763 chr11:133734501 NA -0.36 -5.99 -0.31 5.46e-9 Childhood ear infection; CRC cis rs8180040 0.764 rs12630534 chr3:47001043 T/C cg02527881 chr3:46936655 PTH1R -0.42 -8.02 -0.4 1.89e-14 Colorectal cancer; CRC cis rs1997103 0.863 rs2140916 chr7:55403154 A/C cg17469321 chr7:55412551 NA 0.73 11.31 0.53 2.87e-25 QRS interval (sulfonylurea treatment interaction); CRC cis rs4766646 0.619 rs7966820 chr12:110302270 A/G cg01252219 chr12:110302105 GLTP -0.38 -6.0 -0.31 5.2e-9 Metabolite levels (MHPG); CRC cis rs11098499 0.691 rs12510133 chr4:120271344 A/C cg09307838 chr4:120376055 NA 0.6 9.3 0.46 1.95e-18 Corneal astigmatism; CRC cis rs4836694 0.574 rs67899211 chr9:132935614 G/A cg05251000 chr9:132935664 FREQ 0.52 7.8 0.4 8.29e-14 Alzheimer's disease (cognitive decline); CRC cis rs7538876 0.903 rs6688886 chr1:17753639 G/A cg07965774 chr1:17746286 RCC2 0.33 6.07 0.32 3.59e-9 Basal cell carcinoma; CRC cis rs7811142 1.000 rs6975729 chr7:100028187 C/T cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.99 13.63 0.6 7.31e-34 Platelet count; CRC cis rs7927771 0.965 rs34958982 chr11:47547046 T/C cg18512352 chr11:47633146 NA -0.48 -9.49 -0.46 4.89e-19 Subjective well-being; CRC trans rs6984305 0.541 rs17716118 chr8:9180134 A/G cg21774064 chr8:1626419 DLGAP2 -0.58 -6.47 -0.34 3.45e-10 Liver enzyme levels (alkaline phosphatase); CRC cis rs2486012 1.000 rs2485991 chr1:44391722 C/T cg12908607 chr1:44402522 ARTN -0.42 -5.82 -0.31 1.43e-8 Intelligence (multi-trait analysis); CRC cis rs1499614 1.000 rs2659913 chr7:66157336 T/A cg12463550 chr7:65579703 CRCP 0.64 5.79 0.3 1.66e-8 Gout; CRC cis rs11098499 0.826 rs4472123 chr4:120236630 T/A cg24375607 chr4:120327624 NA 0.45 7.12 0.37 6.85e-12 Corneal astigmatism; CRC trans rs7428796 0.507 rs11127935 chr3:86364123 C/T cg02184338 chr7:101331866 NA -0.44 -6.53 -0.34 2.47e-10 Myopia (pathological); CRC cis rs8031584 0.652 rs2691683 chr15:31135060 A/G cg08704250 chr15:31115839 NA 0.56 9.87 0.48 2.67e-20 Huntington's disease progression; CRC cis rs10256972 0.552 rs2960830 chr7:1200641 T/C cg18402987 chr7:1209562 NA 0.6 9.31 0.46 1.84e-18 Longevity;Endometriosis; CRC trans rs13096480 0.583 rs17598137 chr3:49891362 G/T cg27480539 chr19:16770792 TMEM38A;C19orf42 0.43 6.23 0.32 1.43e-9 Intelligence (multi-trait analysis); CRC cis rs11098499 0.908 rs11098527 chr4:120399906 A/G cg09307838 chr4:120376055 NA 0.71 11.02 0.52 2.99e-24 Corneal astigmatism; CRC cis rs2032447 0.839 rs199751 chr6:26015583 T/C cg17691542 chr6:26056736 HIST1H1C 0.42 5.73 0.3 2.28e-8 Intelligence (multi-trait analysis); CRC cis rs1971762 0.527 rs6580953 chr12:54021138 T/C cg06632207 chr12:54070931 ATP5G2 0.49 8.66 0.43 2.2e-16 Height; CRC trans rs4942242 0.763 rs7327129 chr13:44233014 T/C cg26741380 chr15:41871084 TYRO3 -0.48 -7.11 -0.36 7.14e-12 Response to tocilizumab in rheumatoid arthritis; CRC cis rs9467711 0.591 rs13208859 chr6:25894609 G/A cg16898833 chr6:26189333 HIST1H4D 0.87 7.3 0.37 2.2e-12 Autism spectrum disorder or schizophrenia; CRC cis rs798554 0.757 rs1182185 chr7:2872233 A/G cg19717773 chr7:2847554 GNA12 -0.44 -6.54 -0.34 2.35e-10 Height; CRC trans rs2303319 0.504 rs56026147 chr2:162614089 T/C cg22902534 chr3:183892754 AP2M1 -0.7 -6.1 -0.32 2.96e-9 Cognitive function; CRC trans rs2727020 0.894 rs10839265 chr11:49369733 C/T cg15704280 chr7:45808275 SEPT13 -0.77 -10.34 -0.5 7.21e-22 Coronary artery disease; CRC cis rs9910055 1.000 rs2071167 chr17:42287519 A/G cg19774624 chr17:42201019 HDAC5 0.57 8.56 0.43 4.52e-16 Total body bone mineral density; CRC cis rs2077654 0.822 rs12280242 chr11:17433737 C/T cg25308976 chr11:17434268 ABCC8 0.81 8.39 0.42 1.48e-15 Gout; CRC cis rs9826463 0.757 rs2229032 chr3:142178144 A/G cg20824294 chr3:142316082 PLS1 -0.38 -6.49 -0.34 3.14e-10 QRS duration in Tripanosoma cruzi seropositivity; CRC trans rs11098499 0.708 rs1546506 chr4:120241240 T/C cg25214090 chr10:38739885 LOC399744 0.54 8.48 0.42 7.86e-16 Corneal astigmatism; CRC cis rs1799949 1.000 rs11657835 chr17:41291953 C/G cg19454999 chr17:41278357 BRCA1;NBR2 0.54 8.28 0.42 3.06e-15 Menopause (age at onset); CRC cis rs9381040 0.655 rs4140578 chr6:41041829 A/G cg25110423 chr6:41068646 NFYA;LOC221442 -0.4 -6.04 -0.32 4.23e-9 Alzheimer's disease (late onset); CRC cis rs4663866 1.000 rs71426510 chr2:239178909 T/G cg16914508 chr2:239161102 PER2 0.77 7.86 0.4 5.51e-14 Irritable bowel syndrome; CRC cis rs4862750 0.914 rs1991255 chr4:187875340 G/A cg06074448 chr4:187884817 NA -0.6 -11.25 -0.53 4.69e-25 Lobe attachment (rater-scored or self-reported); CRC cis rs2522056 1.000 rs62385693 chr5:131773674 T/C cg20512303 chr5:131592959 PDLIM4 -0.35 -5.65 -0.3 3.47e-8 Lymphocyte counts;Fibrinogen; CRC trans rs7937682 0.889 rs493865 chr11:111495178 A/C cg18187862 chr3:45730750 SACM1L 0.47 6.78 0.35 5.68e-11 Primary sclerosing cholangitis; CRC cis rs12893668 0.572 rs2273175 chr14:104160141 T/C cg08213375 chr14:104286397 PPP1R13B 0.45 7.31 0.37 2.03e-12 Reticulocyte count; CRC cis rs12745968 0.619 rs10874738 chr1:93224219 T/A cg17283838 chr1:93427260 FAM69A -0.43 -5.78 -0.3 1.77e-8 Bipolar disorder and schizophrenia; CRC cis rs10256972 0.706 rs12701970 chr7:1121958 T/C cg27094323 chr7:1216898 NA -0.4 -6.39 -0.33 5.6e-10 Longevity;Endometriosis; CRC trans rs4692589 0.865 rs6553486 chr4:170984825 C/G cg14764050 chr21:46221651 UBE2G2 0.44 6.12 0.32 2.71e-9 Anxiety disorder; CRC cis rs12190007 0.547 rs3006184 chr6:169805128 C/T cg15038512 chr6:170123185 PHF10 -0.39 -6.05 -0.32 3.86e-9 Obesity-related traits; CRC cis rs7927771 0.832 rs935914 chr11:47387599 C/T cg20307385 chr11:47447363 PSMC3 0.61 9.07 0.45 1.07e-17 Subjective well-being; CRC trans rs2727020 0.521 rs7101761 chr11:49598178 G/A cg18944383 chr4:111397179 ENPEP 0.46 6.06 0.32 3.75e-9 Coronary artery disease; CRC trans rs9322817 0.583 rs7770002 chr6:105173445 A/G cg05994458 chr11:13484274 BTBD10 0.49 6.23 0.32 1.4e-9 Thyroid stimulating hormone; CRC cis rs12024301 0.557 rs6699011 chr1:183622379 A/G cg11505048 chr1:183622726 RGL1;APOBEC4 0.78 6.97 0.36 1.78e-11 Peripheral arterial disease (traffic-related air pollution interaction); CRC cis rs1949733 0.598 rs16842480 chr4:8535621 G/T cg13073564 chr4:8508604 NA 0.4 6.06 0.32 3.66e-9 Response to antineoplastic agents; CRC cis rs9902453 0.808 rs56216220 chr17:28209182 G/A cg26525008 chr17:28256777 EFCAB5;SSH2 0.59 8.81 0.44 7.18e-17 Coffee consumption (cups per day); CRC cis rs7918232 0.830 rs10764672 chr10:27392541 A/C cg14240646 chr10:27532245 ACBD5 0.75 9.2 0.45 4.15e-18 Breast cancer; CRC cis rs2153535 0.563 rs1737586 chr6:8535897 C/T cg07606381 chr6:8435919 SLC35B3 0.68 11.34 0.53 2.25e-25 Motion sickness; CRC cis rs9902453 0.765 rs8071576 chr17:28188554 A/G cg26525008 chr17:28256777 EFCAB5;SSH2 0.69 11.37 0.53 1.8e-25 Coffee consumption (cups per day); CRC cis rs10540 1.000 rs12419716 chr11:503385 C/G cg08200582 chr11:442649 ANO9 -0.71 -7.44 -0.38 8.72e-13 Body mass index; CRC cis rs916888 0.773 rs169201 chr17:44790203 A/G cg17911788 chr17:44343683 NA -0.67 -7.57 -0.38 3.9e-13 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; CRC cis rs6952808 1.000 rs12699404 chr7:1894022 A/T cg00106254 chr7:1943704 MAD1L1 -0.51 -7.18 -0.37 4.67e-12 Bipolar disorder and schizophrenia; CRC cis rs736408 0.527 rs2577831 chr3:52628056 C/A cg07507251 chr3:52567010 NT5DC2 0.48 7.49 0.38 6.54e-13 Bipolar disorder; CRC cis rs2836974 0.897 rs34394827 chr21:40528087 T/C cg17971929 chr21:40555470 PSMG1 0.8 11.82 0.55 4.06e-27 Cognitive function; CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg26251429 chr2:28113398 BRE;RBKS;LOC100302650 0.42 6.8 0.35 5.06e-11 Obesity-related traits; CRC cis rs2032447 1.000 rs2032447 chr6:26044369 A/G cg03264133 chr6:25882463 NA -0.42 -5.91 -0.31 8.47e-9 Intelligence (multi-trait analysis); CRC cis rs9925964 0.933 rs12448321 chr16:31048280 C/T cg03418659 chr16:31128414 MYST1 0.47 6.78 0.35 5.52e-11 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); CRC cis rs8177179 0.967 rs6439436 chr3:133453779 C/T cg16262614 chr3:133464971 TF -0.51 -9.64 -0.47 1.59e-19 Iron status biomarkers (transferrin levels); CRC cis rs6570726 0.935 rs388394 chr6:145852689 C/T cg05347473 chr6:146136440 FBXO30 0.41 6.47 0.34 3.46e-10 Lobe attachment (rater-scored or self-reported); CRC cis rs9549260 0.564 rs8000965 chr13:41279488 C/T cg21288729 chr13:41239152 FOXO1 0.43 6.76 0.35 6.47e-11 Red blood cell count; CRC cis rs7917772 0.503 rs7893155 chr10:104294228 C/A cg11453585 chr10:104263688 ACTR1A;SUFU 0.91 17.49 0.69 6.57e-49 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; CRC cis rs2046867 0.818 rs17010195 chr3:72872852 A/G cg25664220 chr3:72788482 NA 0.39 5.9 0.31 8.87e-9 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; CRC cis rs3741404 0.620 rs2236647 chr11:63964605 A/G cg06219103 chr11:63990595 FERMT3 0.45 7.27 0.37 2.63e-12 Platelet count; CRC trans rs12190007 0.547 rs3006179 chr6:169822467 C/G cg17554553 chr10:31321002 ZNF438 0.36 6.21 0.32 1.59e-9 Obesity-related traits; CRC cis rs1847505 0.663 rs8002365 chr13:61589772 A/G cg14094164 chr13:61491000 NA -0.3 -5.82 -0.31 1.41e-8 Polychlorinated biphenyl levels; CRC cis rs763014 1.000 rs7205409 chr16:642610 A/G cg18653534 chr16:772142 FAM173A -0.36 -5.8 -0.3 1.54e-8 Height; CRC cis rs5769765 0.862 rs138856 chr22:50199378 G/T cg22709217 chr22:50311962 ALG12;CRELD2 -0.82 -11.24 -0.53 4.89e-25 Schizophrenia; CRC cis rs447 1.000 rs7804563 chr7:83777694 G/A cg22846510 chr7:83753280 SEMA3A -0.55 -6.79 -0.35 5.24e-11 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); CRC trans rs944961 0.782 rs7036147 chr9:122589164 A/G cg02709840 chr16:67062875 CBFB 0.39 6.24 0.33 1.36e-9 Liver disease severity in Alagille syndrome; CRC cis rs10504229 0.593 rs76118562 chr8:57988110 G/C cg08219700 chr8:58056026 NA 0.56 6.4 0.33 5.3e-10 Developmental language disorder (linguistic errors); CRC cis rs7605378 0.528 rs812760 chr2:200724372 C/T cg17644776 chr2:200775616 C2orf69 0.48 7.64 0.39 2.33e-13 Osteoporosis; CRC cis rs6570726 0.599 rs9376951 chr6:145898911 C/T cg05347473 chr6:146136440 FBXO30 0.5 7.23 0.37 3.41e-12 Lobe attachment (rater-scored or self-reported); CRC trans rs7647973 0.593 rs62262730 chr3:49808274 T/G cg21665057 chr3:196295764 WDR53;FBXO45 0.59 6.15 0.32 2.25e-9 Menarche (age at onset); CRC cis rs4589502 1.000 rs4589502 chr15:67155069 C/T cg12317470 chr15:67143691 NA 0.68 8.14 0.41 8.52e-15 Lung cancer (smoking interaction); CRC cis rs2692947 0.702 rs4907291 chr2:96654605 T/G cg23100626 chr2:96804247 ASTL 0.24 6.76 0.35 6.17e-11 Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; CRC cis rs2832191 0.740 rs2832177 chr21:30478353 G/A cg24692254 chr21:30365293 RNF160 -0.82 -15.15 -0.64 1.08e-39 Dental caries; CRC cis rs10089 1.000 rs13355233 chr5:127425350 A/G cg25462716 chr5:127418816 SLC12A2;FLJ33630 -0.77 -10.76 -0.51 2.55e-23 Ileal carcinoids; CRC cis rs17376456 0.825 rs10054903 chr5:93281491 C/A cg21475434 chr5:93447410 FAM172A 0.83 8.23 0.41 4.37e-15 Diabetic retinopathy; CRC trans rs12887734 0.524 rs4906363 chr14:104210239 G/A cg06206626 chr22:26825900 ASPHD2 0.43 6.23 0.32 1.42e-9 Schizophrenia;Autism spectrum disorder or schizophrenia; CRC cis rs1801251 1.000 rs1446308 chr2:233639309 T/C cg25237894 chr2:233734115 C2orf82 0.54 8.76 0.43 1.05e-16 Coronary artery disease; CRC cis rs950776 0.518 rs12591557 chr15:78811732 A/G cg06917634 chr15:78832804 PSMA4 0.66 10.52 0.5 1.6400000000000001e-22 Sudden cardiac arrest; CRC cis rs6089584 0.888 rs6061966 chr20:60607936 C/G cg23262073 chr20:60523788 NA -0.47 -7.23 -0.37 3.36e-12 Body mass index;